<110> The General Hospital Corporation doing business as Massachusetts General Hospital / Bayer AG

<120> Nucleotide sequences involved in pain

<130> LeA 35693 Foreign Countries

<150> US 60/312,147
<151> 2001-08-14

<150> US 60/346,382
<151> 2001-11-01

<150> US 60/333,347
<151> 2001-11-26

<160> 14715

<170> Perl script


<210> 1
<211> 1214
<212> DNA
<213> Rattus norvegicus
<308> A09811
<400> 1

gaattccgg  ccccgcgct  ccgctgctc  tgccgtcgc  gctcttgct  ctgctgttg  60
gcgcgggcg  ttgcggtcc  ggggtgcgc  ccgaggtgc  gttccgctg  ccaccctgc  120
cgcccgagc  tctggccgc  tgcggaccc  cacccgacg  gccctgcgc  gagctggtg  180
gagagcccg  ctgcggttg  tgctccgtg  gcgcacgac  ggagggcga  gcttgcggc  240
tctacatcc  gcgctgcgc  cagacgtta  gctgttacc  caacccggg  tccgagctg  300
ccctgaagg  actggtcac  ggcgcgggt  cctgtgaaa  gagacgcgt  ggcgccacc  360
cacagcagg  tgcagacag  gaggatgac  actcggagg  aggcctggt  gagaaccat  420
tggacggaa  catgaacat  ttgggaggc  gcagtgctg  ccggaagcc  cctaagtca  480
gcatgaagg  actggctgt  ttccgggag  aggtcaacg  gcagcaccg  cagatgggc  540
aaggtgcca  acacctcag  ctggaggag  ccaagaagc  gcgcccacc  cctgccagg  600
ccccttgcc  gcaggagct  gaccaggtc  tggagcgca  ctccaccat  cgccttccg  660
atgatcggg  tcctctgga  catctctac  ccctgcata  ccccaactg  gacaagcat  720
gcctgtaca  cctcaaaca  tgcaagatg  ctctgaatg  acagcgtgg  gagtgctgg  780
gtgtgaacc  caatactgg  aagccaatc  agggagctc  caccatccg  ggagacccc  840
agtgccatc  cttctacaa  gagcagcag  agaatgatg  ggctcacgc  caaagggtg  900
agtaaacca  agccagtcg  tgcctggct  ccccacccc  aacaccagc  gaaatggag  960
gtgtcaggg  gatgggtgt  gaggatttc  cagttttga  acatgtatt  atatttgga  1020
agagaccaa  actgagctc  gaagccccc  tgcgccccc  agtggcagt  aacctgtac  1080
tccgttcct  cttctaata  agagggtgg  ggcactggg  atactgggt  caggcttgg  1140
aatggggaa  gaaattttt  tttttgaac  cctgtgtct  ttttactta  gattaaagg  1200
aggaaacgg  attc  1214



<210> 2
<211> 300
<212> PRT
<213> Rattus norvegicus
<308> A09811
<400> 2

Pro Gly Pro Ala Leu Pro Leu Leu Leu Pro Ser Leu Leu Leu Leu Leu 
  1               5                  10                  15
Leu Leu Gly Ala Gly Gly Cys Gly Pro Gly Val Arg Ala Glu Val Leu 
             20                  25                  30
Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro 
         35                  40                  45
Pro Pro Asp Ala Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys Gly 
     50                  55                  60
Cys Cys Ser Val Cys Ala Arg Gln Glu Gly Glu Ala Cys Gly Val Tyr 
 65                  70                  75                  80
Ile Pro Arg Cys Ala Gln Thr Leu Arg Cys Tyr Pro Asn Pro Gly Ser 
                 85                  90                  95
Glu Leu Pro Leu Lys Ala Leu Val Thr Gly Ala Gly Thr Cys Glu Lys 
             100                105                110
Arg Arg Val Gly Ala Thr Pro Gln Gln Val Ala Asp Ser Glu Asp Asp 
         115                120                125
His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp Gly Thr Met Asn 
     130                135                140
Met Leu Gly Gly Ser Ser Ala Gly Arg Lys Pro Pro Lys Ser Gly Met 
 145                150                155                160
Lys Glu Leu Ala Val Phe Arg Glu Lys Val Asn Glu Gln His Arg Gln 
                 165                170                175
Met Gly Lys Gly Ala Lys His Leu Ser Leu Glu Glu Pro Lys Lys Leu 
             180                185                190
Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val 
         195                200                205
Leu Glu Arg Ile Ser Thr Met Arg Leu Pro Asp Asp Arg Gly Pro Leu 
     210                215                220
Glu His Leu Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu 
 225                230                235                240
Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu 
                 245                250                255
Cys Trp Cys Val Asn Pro Asn Thr Gly Lys Pro Ile Gln Gly Ala Pro 
             260                265                270
Thr Ile Arg Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln 
         275                280                285
Glu Asn Asp Gly Ala His Ala Gln Arg Val Gln Ter 
     290                295                300



<210> 3
<211> 1421
<212> DNA
<213> Homo sapiens
<308> XM_002636
<400> 3

ggcgaggga  gaggaagaa  cggaggagg  ggctcccgc  ctcgcaggg  cgtgccacc  60
gcccgcccg  ccgctcgct  gctcgcccg  cgcgccgcg  tgccgaccg  cagcatgct  120
ccgagagtg  gctgccccg  gctgccgct  ccgccgccg  cgctgctgc  gctgctgct  180
ctgctactg  gcgcgagtg  cggcggcgg  ggggcgcgc  cggaggtgc  gttccgctg  240
ccgccctgc  cacccgagc  cctggccgc  tgcgggccc  cgccggttg  gccgcccgc  300
gcggtggcc  cagtggccg  aggcgcccg  atgccatgc  cggagctcg  ccgggagcc  360
ggctgcggc  gctgctcgg  gtgcgcccg  ctggagggc  aggcgtgcg  cgtctacac  420
ccgcgctgc  gccaggggc  gcgctgcta  ccccacccg  gctccgagc  gcccctgca  480
gcgctggtc  tgggcgagg  cacttgtga  aagcgccgg  acgccgagt  tggcgccag  540
ccggagcag  ttgcagaca  tggcgatga  cactcagaa  gaggcctgg  ggagaacca  600
gtggacagc  ccatgaaca  gttgggcgg  ggaggcagt  ctggccgga  gcccctcaa  660
tcgggtatg  aggagctgg  cgtgttccg  gagaaggtc  ctgagcagc  ccggcagat  720
ggcaagggt  gcaagcatc  ccttggcct  gaggagccc  agaagctgc  accaccccc  780
gccaggact  cctgccaac  ggaactgga  caggtcctg  agcggatct  caccatgcg  840
cttccggat  agcggggcc  tctggagca  ctctactcc  tgcacatcc  caactgtga  900
aagcatggc  tgtacaacc  caaacagtg  aagatgtct  tgaacgggc  gcgtgggga  960
tgctggtgt  tgaacccca  caccgggaa  ctgatccag  gagccccca  catccgggg  1020
gaccccgag  gtcatctct  ctacaatga  cagcaggag  ctcgcgggg  gcacaccca  1080
cggatgcag  agaccgcag  cagccggtg  ctggcgccc  tgccccccg  ccctctcca  1140
acaccggca  aaaacggag  gtgcttggg  ggtgggtgc  ggaggattt  ccagttctg  1200
cacacgtat  tatatttgg  aagagacca  caccgagct  ggcacctcc  cggcctctc  1260
cttcccagc  gcagatgcc  cacctgctc  ttcttgctt  ccccggggg  ggaaggggg  1320
tgtggtcgg  gagctgggg  acaggtttg  ggaggggga  gagaaattt  tatttttga  1380
cccctgtgt  ccttttgca  aagattaaa  gaaggaaaa  t  1421



<210> 4
<211> 325
<212> PRT
<213> Homo sapiens
<308> XP_002636
<400> 4

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
  1               5                  10                  15
Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly Gly Gly Gly 
             20                  25                  30
Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu 
         35                  40                  45
Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val 
     50                  55                  60
Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg 
 65                  70                  75                  80
Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu 
                 85                  90                  95
Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr 
             100                105                110
Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu 
         115                120                125
Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu 
     130                135                140
Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu 
 145                150                155                160
Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala 
                 165                170                175
Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg 
             180                185                190
Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His 
         195                200                205
His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg 
     210                215                220
Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr 
 225                230                235                240
Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu 
                 245                250                255
His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys 
             260                265                270
Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro 
         275                280                285
Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro 
     290                295                300
Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His 
 305                310                315                320
Thr Gln Arg Met Gln 
                 325



<210> 5
<211> 158
<212> DNA
<213> Rattus norvegicus
<308> AA108277
<400> 5

accctttga  ctagaagct  tctattctg  ccctcaagc  gttccatat  cagaagcaa  60
aatcggccg  tttgtcgtt  agaatgttt  tgcacagaa  atggagaaa  tctaaagtg  120
aagtgcgcg  gacacacat  catttcaca  atccgctc  158



<210> 6
<211> 859
<212> PRT
<213> Rattus norvegicus
<308> NP_038587
<400> 6

Met Ser Val Val Gly Leu Glu Leu Gly Ser Gln Ser Cys Tyr Ile Ala 
  1               5                  10                  15
Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Phe Ser Asp 
             20                  25                  30
Arg Cys Thr Pro Ser Val Ile Ser Phe Gly Ser Lys Asn Arg Thr Ile 
         35                  40                  45
Gly Val Ala Ala Lys Asn Gln Gln Ile Thr His Ala Asn Asn Thr Val 
     50                  55                  60
Ser Ser Phe Lys Arg Phe His Gly Arg Ala Phe Asn Asp Pro Phe Ile 
 65                  70                  75                  80
Gln Lys Glu Lys Glu Asn Leu Ser Tyr Asp Leu Val Pro Met Lys Asn 
                 85                  90                  95
Gly Gly Val Gly Ile Lys Val Met Tyr Met Asp Glu Glu His Phe Phe 
             100                105                110
Ser Val Glu Gln Ile Thr Ala Met Leu Leu Thr Lys Leu Lys Glu Thr 
         115                120                125
Ala Glu Asn Asn Leu Lys Lys Pro Val Thr Asp Cys Val Ile Ser Val 
     130                135                140
Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Leu Asp Arg Ala 
 145                150                155                160
Gln Ile Val Gly Leu Asn Cys Leu Arg Leu Met Asn Asp Met Thr Ala 
                 165                170                175
Val Ala Leu Asn Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Asn Ala Glu 
             180                185                190
Glu Lys Pro Arg Val Val Val Phe Val Asp Met Gly His Ser Ser Phe 
         195                200                205
Gln Val Ser Ala Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Gly 
     210                215                220
Thr Ala Phe Asp Pro Phe Leu Gly Gly Lys Asn Phe Asp Glu Lys Leu 
 225                230                235                240
Val Glu His Phe Cys Ala Glu Phe Lys Thr Lys Tyr Lys Leu Asp Ala 
                 245                250                255
Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu His Gln Glu Cys Glu Lys 
             260                265                270
Leu Lys Lys Leu Met Ser Ser Asn Ser Thr Asp Leu Pro Leu Asn Ile 
         275                280                285
Glu Cys Phe Met Asn Asp Lys Asp Val Ser Gly Lys Met Asn Arg Ser 
     290                295                300
Gln Phe Glu Glu Leu Cys Ala Glu Leu Leu Gln Lys Ile Glu Val Pro 
 305                310                315                320
Leu His Ser Leu Met Ala Gln Thr Gln Leu Lys Ala Glu Asp Val Ser 
                 325                330                335
Ala Ile Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
             340                345                350
Arg Ile Ala Lys Phe Phe Gly Lys Asp Val Ser Thr Thr Leu Asn Ala 
         355                360                365
Asp Glu Ala Val Arg Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
     370                375                380
Pro Ala Phe Lys Val Arg Glu Phe Ser Val Thr Asp Ala Val Pro Phe 
 385                390                395                400
Pro Ile Ser Leu Val Trp Asn His Asp Ser Glu Glu Thr Glu Gly Val 
                 405                410                415
His Glu Val Phe Ser Arg Asn His Ala Ala Pro Phe Ser Lys Val Leu 
             420                425                430
Thr Phe Leu Arg Arg Gly Pro Phe Glu Leu Glu Ala Phe Tyr Ser Asp 
         435                440                445
Pro Gln Gly Val Pro Tyr Pro Glu Ala Lys Ile Gly Arg Phe Val Val 
     450                455                460
Gln Asn Val Ser Ala Gln Lys Asp Gly Glu Lys Ser Arg Val Lys Val 
 465                470                475                480
Lys Val Arg Val Asn Thr His Gly Ile Phe Thr Ile Ser Thr Ala Ser 
                 485                490                495
Met Val Glu Lys Val Pro Thr Glu Glu Glu Asp Gly Ser Ser Leu Glu 
             500                505                510
Ala Asp Met Glu Cys Phe Gln Asn Gln Arg Pro Thr Glu Ser Ser Asp 
         515                520                525
Val Asp Lys Asn Ile Gln Gln Asp Asn Ser Glu Ala Gly Thr Gln Pro 
     530                535                540
Gln Val Gln Thr Asp Gly Gln Gln Thr Ser Gln Ser Pro Pro Ser Pro 
 545                550                555                560
Glu Leu Thr Ser Glu Glu Ser Lys Thr Pro Asp Ala Asp Lys Ala Asn 
                 565                570                575
Glu Lys Lys Val Asp Gln Pro Pro Glu Ala Lys Lys Pro Lys Ile Lys 
             580                585                590
Val Val Asn Val Glu Leu Pro Val Glu Ala Asn Leu Val Trp Gln Leu 
         595                600                605
Gly Arg Asp Leu Leu Asn Met Tyr Ile Glu Thr Glu Gly Lys Met Ile 
     610                615                620
Met Gln Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val 
 625                630                635                640
Glu Glu Cys Val Tyr Glu Phe Arg Asp Lys Leu Cys Gly Pro Tyr Glu 
                 645                650                655
Lys Phe Ile Cys Glu Gln Glu His Glu Lys Phe Leu Arg Leu Leu Thr 
             660                665                670
Glu Thr Glu Asp Trp Leu Tyr Glu Glu Gly Glu Asp Gln Ala Lys Gln 
         675                680                685
Ala Tyr Ile Asp Lys Leu Glu Glu Leu Met Lys Met Gly Thr Pro Val 
     690                695                700
Lys Val Arg Phe Gln Glu Ala Glu Glu Arg Pro Lys Val Leu Glu Glu 
 705                710                715                720
Leu Gly Gln Arg Leu Gln His Tyr Ala Lys Ile Ala Ala Asp Phe Arg 
                 725                730                735
Gly Lys Asp Glu Lys Tyr Asn His Asn Asp Glu Ser Glu Met Lys Lys 
             740                745                750
Val Glu Lys Ser Val Asn Glu Val Met Glu Trp Met Asn Asn Val Met 
         755                760                765
Asn Ala Gln Ala Lys Arg Ser Leu Asp Gln Asp Pro Val Val Arg Thr 
     770                775                780
His Glu Ile Arg Ala Lys Val Lys Glu Leu Asn Asn Val Cys Glu Pro 
 785                790                795                800
Val Val Thr Gln Pro Lys Pro Lys Ile Glu Ser Pro Lys Leu Glu Arg 
                 805                810                815
Thr Pro Asn Gly Pro Asn Ile Asp Lys Lys Glu Asp Leu Glu Gly Lys 
             820                825                830
Asn Asn Leu Gly Ala Glu Arg Pro His Gln Asn Gly Glu Cys His Pro 
         835                840                845
Asn Glu Lys Gly Ser Val Asn Met Asp Leu Asp 
     850                855



<210> 7
<211> 3612
<212> DNA
<213> Homo sapiens
<308> AB003334
<400> 7

gaggaagtg  gacctcccc  tttgggtcg  tagttcagc  ccggcgccg  tgtgcgagc  60
gcggcagag  gaggcaggc  acccgaggt  cggagcgac  tgcggaggc  gagccccgc  120
ttctcccag  gtttcttat  agccagccg  cgctgtccc  gggggagta  gaggctcct  180
acaggccgc  gctgtctgt  tgtccttct  agtgtcaga  gaacggcca  accccgcgg  240
ccggagcag  acgcggcca  ggcagaaag  ggcggcagg  gaagcaggc  gggggccgg  300
ggacgcaga  cgagacccg  ggcggaggc  gaccgcgag  cggccatgt  ggtggtggg  360
ttggacgtg  gctcgcaga  ctgctacat  gcggtagcc  gggccgggg  catcgagac  420
atcgccaat  agttcagcg  ccggtgcac  ccgtcagtc  tatcatttg  atcaaaaaa  480
agaacaatc  gagttgcag  caaaaatca  caaatcact  atgcaaaca  tacggtgtc  540
aacttcaaa  gatttcatg  ccgagcatt  aacgacccc  tcattcaaa  ggagaagga  600
aacttgagt  acgatttgg  tccattgaa  aatggtgga  ttggaataa  ggtaatgta  660
atgggtgaa  aacatctat  tagtgtgga  cagataaca  ccatgttgt  gactaagct  720
aaggaaact  ctgaaaaca  cctcaagaa  ccagtaaca  attgtgtta  ttcagtccc  780
tccttcttt  cagatgctg  gaggcgatc  gtgttagat  ctgcacaga  tgttggcct  840
aactgttta  gacttatga  tgacatgac  gctgttgct  tgaattacg  aatttataa  900
caggatctc  caagcctgg  tgagaaacc  cggatagtg  tttttgttg  tatgggaca  960
tcagctttt  aagtgtctg  ttgtgcttt  aacaaggga  aattgaagg  actgggaac  1020
gcttttgat  ctttcttag  aggaaaaaa  ttcgatgaa  agttagtgg  acatttctg  1080
gcagaattt  aaactaagt  caagttgga  gcaaaatcc  aaatacgag  actcctacg  1140
ctgtatcag  aatgtgaaa  actgaaaaa  ctaatgagc  ctaacagca  agaccttcc  1200
ctgaatatc  aatgcttta  gaatgataa  gatgtttcc  gaaagatga  caggtcaca  1260
tttgaagaa  tctgtgctg  acttctgca  aagatagaa  taccccttt  ttcactgtt  1320
gaacaaact  atctcaaag  agaagatgt  agtgcagtt  agattgttg  aggcgctac  1380
cgaattcca  ctgtgaagg  aagaattgc  aaattcttt  gaaaagata  tagcacaac  1440
ctcaatgca  atgaagcag  agccagagg  tgtgcatta  agtgtgcaa  actttcccc  1500
gcatttaaa  ttagagaat  ttccgtcac  gatgcagtt  cttttccaa  atctctgat  1560
tggaaccat  attcagaag  tactgaagg  gttcatgaa  tctttagtc  aaaccatgc  1620
gctcctttc  ccaaagttc  cacctttct  agaaggggg  cttttgagc  agaagcttt  1680
tattctgat  cccaaggag  tccatatcc  gaagcaaaa  taggccgct  tgtagttca  1740
aatgtttct  cacagaaag  tggagaaaa  tctagagta  aagtcaaag  gcgagtcaa  1800
acccatggc  ttttcacca  ctctacggc  tctatggtg  agaaagtcc  aactgagga  1860
aatgaaatg  cttctgaag  tgacatgga  tgtctgaat  agagaccac  agaaaaccc  1920
gacactgat  aaaatgtcc  gcaagacaa  agtgaagct  gaacacagc  ccaggtaca  1980
actgatgct  aacaaacct  acagtctcc  ccttcacct  aacttacct  agaagaaaa  2040
aaaatccca  atgctgaca  agcaaatga  aaaaaagtt  accagcctc  agaagctaa  2100
aagcccaaa  taaaggtgg  gaatgttga  ctgcctatt  aagccaact  ggtctggca  2160
ttagggaaa  accttctta  catgtatat  gagacagag  gtaagatga  aatgcaaga  2220
aaattggaa  aagaaagga  tgatgctaa  aatgcagtt  aggaatatg  gtatgagtt  2280
agagacaag  tgtgtggac  atatgaaaa  tttatatgt  agcaggatc  tcaaaattt  2340
ttgagactc  tcacagaaa  tgaagactg  ctgtatgaa  aaggagagg  ccaagctaa  2400
caagcatat  ttgacaagt  ggaagaatt  atgaaaatt  gcactccag  taaagttcg  2460
tttcaggaa  ctgaagaac  gccaaaaat  tttgaagaa  taggacaga  gctgcagca  2520
tatgccaag  tagcagctg  cttcagaaa  aaggatgag  aatacaacc  tattgatga  2580
tctgaaatg  aaaaagtgg  gaagtctgt  aatgaagtg  tggaatgga  gaataatgt  2640
atgaatgct  aggctaaaa  gagtcttga  caggatcca  ttgtacgtg  tcaggaaat  2700
aaaacaaaa  tcaaggaat  gaacaacac  tgtgaaccc  ttgtaacac  accgaaacc  2760
aaaattgaa  cacccaaac  ggaaagaac  ccaaatggc  caaatattg  taaaaagga  2820
gaagattta  aagacaaaa  caattttgg  gctgaacct  cacatcaga  tggtgaatg  2880
taccctaat  agaaaaatt  tgttaatat  gacttggac  agataacct  aaattggcc  2940
attccttca  ttaataaaa  atttttgcc  tagtatgtg  ctctacata  catactgaa  3000
ctatttata  tttcttttt  aaggatatt  agaaatttt  tgtattata  ggaaaaaga  3060
aaaaagctt  agtctgtag  ctttatgat  ctaaaaggg  aaattgcct  ggtaacttt  3120
agattcctg  ggaattgtg  attcatact  agctttctg  gcagtctca  catttgcat  3180
actgaggat  aaactgact  ttgtctttt  gagaaaaaa  actgtactg  tgttcaaga  3240
ggctgtgat  aaaatcttt  agcatttgt  cctgccaag  tagttttct  gcattttgc  3300
ctccattca  catgtgtgt  ggtgtggat  tttataaac  agactaagt  tgacttcat  3360
agggctttc  aaaaccatt  ctgtccaag  gaaaatgac  ttttgcttt  atattaaaa  3420
ttcaatgag  aaaacaaaa  ctagtcaaa  gtgttagca  catgcagaa  aaaaacttt  3480
aactttctc  ctcactata  agtatattg  caatgtgaa  gtgtggaat  gaagaaatg  3540
cgatcctgt  gtaactgat  gtgaacact  ttatgagct  taaaataaa  ttcatctta  3600
ggtgtcatt  ct  3612



<210> 8
<211> 858
<212> PRT
<213> Homo sapiens
<308> Q92598
<400> 8

Met Ser Val Val Gly Leu Asp Val Gly Ser Gln Ser Cys Tyr Ile Ala 
  1               5                  10                  15
Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Phe Ser Asp 
             20                  25                  30
Arg Cys Thr Pro Ser Val Ile Ser Phe Gly Ser Lys Asn Arg Thr Ile 
         35                  40                  45
Gly Val Ala Ala Lys Asn Gln Gln Ile Thr His Ala Asn Asn Thr Val 
     50                  55                  60
Ser Asn Phe Lys Arg Phe His Gly Arg Ala Phe Asn Asp Pro Phe Ile 
 65                  70                  75                  80
Gln Lys Glu Lys Glu Asn Leu Ser Tyr Asp Leu Val Pro Leu Lys Asn 
                 85                  90                  95
Gly Gly Val Gly Ile Lys Val Met Tyr Met Gly Glu Glu His Leu Phe 
             100                105                110
Ser Val Glu Gln Ile Thr Ala Met Leu Leu Thr Lys Leu Lys Glu Thr 
         115                120                125
Ala Glu Asn Ser Leu Lys Lys Pro Val Thr Asp Cys Val Ile Ser Val 
     130                135                140
Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Leu Asp Ala Ala 
 145                150                155                160
Gln Ile Val Gly Leu Asn Cys Leu Arg Leu Met Asn Asp Met Thr Ala 
                 165                170                175
Val Ala Leu Asn Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ser Leu Asp 
             180                185                190
Glu Lys Pro Arg Ile Val Val Phe Val Asp Met Gly His Ser Ala Phe 
         195                200                205
Gln Val Ser Ala Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Gly 
     210                215                220
Thr Ala Phe Asp Pro Phe Leu Gly Gly Lys Asn Phe Asp Glu Lys Leu 
 225                230                235                240
Val Glu His Phe Cys Ala Glu Phe Lys Thr Lys Tyr Lys Leu Asp Ala 
                 245                250                255
Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys 
             260                265                270
Leu Lys Lys Leu Met Ser Ser Asn Ser Thr Asp Leu Pro Leu Asn Ile 
         275                280                285
Glu Cys Phe Met Asn Asp Lys Asp Val Ser Gly Lys Met Asn Arg Ser 
     290                295                300
Gln Phe Glu Glu Leu Cys Ala Glu Leu Leu Gln Lys Ile Glu Val Pro 
 305                310                315                320
Leu Tyr Ser Leu Leu Glu Gln Thr His Leu Lys Val Glu Asp Val Ser 
                 325                330                335
Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
             340                345                350
Arg Ile Ala Lys Phe Phe Gly Lys Asp Ile Ser Thr Thr Leu Asn Ala 
         355                360                365
Asp Glu Ala Val Ala Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
     370                375                380
Pro Ala Phe Lys Val Arg Glu Phe Ser Val Thr Asp Ala Val Pro Phe 
 385                390                395                400
Pro Ile Ser Leu Ile Trp Asn His Asp Ser Glu Asp Thr Glu Gly Val 
                 405                410                415
His Glu Val Phe Ser Arg Asn His Ala Ala Pro Phe Ser Lys Val Leu 
             420                425                430
Thr Phe Leu Arg Arg Gly Pro Phe Glu Leu Glu Ala Phe Tyr Ser Asp 
         435                440                445
Pro Gln Gly Val Pro Tyr Pro Glu Ala Lys Ile Gly Arg Phe Val Val 
     450                455                460
Gln Asn Val Ser Ala Gln Lys Asp Gly Glu Lys Ser Arg Val Lys Val 
 465                470                475                480
Lys Val Arg Val Asn Thr His Gly Ile Phe Thr Ile Ser Thr Ala Ser 
                 485                490                495
Met Val Glu Lys Val Pro Thr Glu Glu Asn Glu Met Ser Ser Glu Ala 
             500                505                510
Asp Met Glu Cys Leu Asn Gln Arg Pro Pro Glu Asn Pro Asp Thr Asp 
         515                520                525
Lys Asn Val Gln Gln Asp Asn Ser Glu Ala Gly Thr Gln Pro Gln Val 
     530                535                540
Gln Thr Asp Ala Gln Gln Thr Ser Gln Ser Pro Pro Ser Pro Glu Leu 
 545                550                555                560
Thr Ser Glu Glu Asn Lys Ile Pro Asp Ala Asp Lys Ala Asn Glu Lys 
                 565                570                575
Lys Val Asp Gln Pro Pro Glu Ala Lys Lys Pro Lys Ile Lys Val Val 
             580                585                590
Asn Val Glu Leu Pro Ile Glu Ala Asn Leu Val Trp Gln Leu Gly Lys 
         595                600                605
Asp Leu Leu Asn Met Tyr Ile Glu Thr Glu Gly Lys Met Ile Met Gln 
     610                615                620
Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Glu Glu 
 625                630                635                640
Tyr Val Tyr Glu Phe Arg Asp Lys Leu Cys Gly Pro Tyr Glu Lys Phe 
                 645                650                655
Ile Cys Glu Gln Asp His Gln Asn Phe Leu Arg Leu Leu Thr Glu Thr 
             660                665                670
Glu Asp Trp Leu Tyr Glu Glu Gly Glu Asp Gln Ala Lys Gln Ala Tyr 
         675                680                685
Val Asp Lys Leu Glu Glu Leu Met Lys Ile Gly Thr Pro Val Lys Val 
     690                695                700
Arg Phe Gln Glu Ala Glu Glu Arg Pro Lys Met Phe Glu Glu Leu Gly 
 705                710                715                720
Gln Arg Leu Gln His Tyr Ala Lys Ile Ala Ala Asp Phe Arg Asn Lys 
                 725                730                735
Asp Glu Lys Tyr Asn His Ile Asp Glu Ser Glu Met Lys Lys Val Glu 
             740                745                750
Lys Ser Val Asn Glu Val Met Glu Trp Met Asn Asn Val Met Asn Ala 
         755                760                765
Gln Ala Lys Lys Ser Leu Asp Gln Asp Pro Val Val Arg Ala Gln Glu 
     770                775                780
Ile Lys Thr Lys Ile Lys Glu Leu Asn Asn Thr Cys Glu Pro Val Val 
 785                790                795                800
Thr Gln Pro Lys Pro Lys Ile Glu Ser Pro Lys Leu Glu Arg Thr Pro 
                 805                810                815
Asn Gly Pro Asn Ile Asp Lys Lys Glu Glu Asp Leu Glu Asp Lys Asn 
             820                825                830
Asn Phe Gly Ala Glu Pro Pro His Gln Asn Gly Glu Cys Tyr Pro Asn 
         835                840                845
Glu Lys Asn Ser Val Asn Met Asp Leu Asp 
     850                855



<210> 9
<211> 158
<212> DNA
<213> Rattus norvegicus
<308> AA108277
<400> 9

accctttga  ctagaagct  tctattctg  ccctcaagc  gttccatat  cagaagcaa  60
aatcggccg  tttgtcgtt  agaatgttt  tgcacagaa  atggagaaa  tctaaagtg  120
aagtgcgcg  gacacacat  catttcaca  atccgctc  158



<210> 10
<211> 859
<212> PRT
<213> Rattus norvegicus
<308> NP_038587
<400> 10

Met Ser Val Val Gly Leu Glu Leu Gly Ser Gln Ser Cys Tyr Ile Ala 
  1               5                  10                  15
Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Phe Ser Asp 
             20                  25                  30
Arg Cys Thr Pro Ser Val Ile Ser Phe Gly Ser Lys Asn Arg Thr Ile 
         35                  40                  45
Gly Val Ala Ala Lys Asn Gln Gln Ile Thr His Ala Asn Asn Thr Val 
     50                  55                  60
Ser Ser Phe Lys Arg Phe His Gly Arg Ala Phe Asn Asp Pro Phe Ile 
 65                  70                  75                  80
Gln Lys Glu Lys Glu Asn Leu Ser Tyr Asp Leu Val Pro Met Lys Asn 
                 85                  90                  95
Gly Gly Val Gly Ile Lys Val Met Tyr Met Asp Glu Glu His Phe Phe 
             100                105                110
Ser Val Glu Gln Ile Thr Ala Met Leu Leu Thr Lys Leu Lys Glu Thr 
         115                120                125
Ala Glu Asn Asn Leu Lys Lys Pro Val Thr Asp Cys Val Ile Ser Val 
     130                135                140
Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Leu Asp Arg Ala 
 145                150                155                160
Gln Ile Val Gly Leu Asn Cys Leu Arg Leu Met Asn Asp Met Thr Ala 
                 165                170                175
Val Ala Leu Asn Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Asn Ala Glu 
             180                185                190
Glu Lys Pro Arg Val Val Val Phe Val Asp Met Gly His Ser Ser Phe 
         195                200                205
Gln Val Ser Ala Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Gly 
     210                215                220
Thr Ala Phe Asp Pro Phe Leu Gly Gly Lys Asn Phe Asp Glu Lys Leu 
 225                230                235                240
Val Glu His Phe Cys Ala Glu Phe Lys Thr Lys Tyr Lys Leu Asp Ala 
                 245                250                255
Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu His Gln Glu Cys Glu Lys 
             260                265                270
Leu Lys Lys Leu Met Ser Ser Asn Ser Thr Asp Leu Pro Leu Asn Ile 
         275                280                285
Glu Cys Phe Met Asn Asp Lys Asp Val Ser Gly Lys Met Asn Arg Ser 
     290                295                300
Gln Phe Glu Glu Leu Cys Ala Glu Leu Leu Gln Lys Ile Glu Val Pro 
 305                310                315                320
Leu His Ser Leu Met Ala Gln Thr Gln Leu Lys Ala Glu Asp Val Ser 
                 325                330                335
Ala Ile Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
             340                345                350
Arg Ile Ala Lys Phe Phe Gly Lys Asp Val Ser Thr Thr Leu Asn Ala 
         355                360                365
Asp Glu Ala Val Arg Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
     370                375                380
Pro Ala Phe Lys Val Arg Glu Phe Ser Val Thr Asp Ala Val Pro Phe 
 385                390                395                400
Pro Ile Ser Leu Val Trp Asn His Asp Ser Glu Glu Thr Glu Gly Val 
                 405                410                415
His Glu Val Phe Ser Arg Asn His Ala Ala Pro Phe Ser Lys Val Leu 
             420                425                430
Thr Phe Leu Arg Arg Gly Pro Phe Glu Leu Glu Ala Phe Tyr Ser Asp 
         435                440                445
Pro Gln Gly Val Pro Tyr Pro Glu Ala Lys Ile Gly Arg Phe Val Val 
     450                455                460
Gln Asn Val Ser Ala Gln Lys Asp Gly Glu Lys Ser Arg Val Lys Val 
 465                470                475                480
Lys Val Arg Val Asn Thr His Gly Ile Phe Thr Ile Ser Thr Ala Ser 
                 485                490                495
Met Val Glu Lys Val Pro Thr Glu Glu Glu Asp Gly Ser Ser Leu Glu 
             500                505                510
Ala Asp Met Glu Cys Phe Gln Asn Gln Arg Pro Thr Glu Ser Ser Asp 
         515                520                525
Val Asp Lys Asn Ile Gln Gln Asp Asn Ser Glu Ala Gly Thr Gln Pro 
     530                535                540
Gln Val Gln Thr Asp Gly Gln Gln Thr Ser Gln Ser Pro Pro Ser Pro 
 545                550                555                560
Glu Leu Thr Ser Glu Glu Ser Lys Thr Pro Asp Ala Asp Lys Ala Asn 
                 565                570                575
Glu Lys Lys Val Asp Gln Pro Pro Glu Ala Lys Lys Pro Lys Ile Lys 
             580                585                590
Val Val Asn Val Glu Leu Pro Val Glu Ala Asn Leu Val Trp Gln Leu 
         595                600                605
Gly Arg Asp Leu Leu Asn Met Tyr Ile Glu Thr Glu Gly Lys Met Ile 
     610                615                620
Met Gln Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val 
 625                630                635                640
Glu Glu Cys Val Tyr Glu Phe Arg Asp Lys Leu Cys Gly Pro Tyr Glu 
                 645                650                655
Lys Phe Ile Cys Glu Gln Glu His Glu Lys Phe Leu Arg Leu Leu Thr 
             660                665                670
Glu Thr Glu Asp Trp Leu Tyr Glu Glu Gly Glu Asp Gln Ala Lys Gln 
         675                680                685
Ala Tyr Ile Asp Lys Leu Glu Glu Leu Met Lys Met Gly Thr Pro Val 
     690                695                700
Lys Val Arg Phe Gln Glu Ala Glu Glu Arg Pro Lys Val Leu Glu Glu 
 705                710                715                720
Leu Gly Gln Arg Leu Gln His Tyr Ala Lys Ile Ala Ala Asp Phe Arg 
                 725                730                735
Gly Lys Asp Glu Lys Tyr Asn His Asn Asp Glu Ser Glu Met Lys Lys 
             740                745                750
Val Glu Lys Ser Val Asn Glu Val Met Glu Trp Met Asn Asn Val Met 
         755                760                765
Asn Ala Gln Ala Lys Arg Ser Leu Asp Gln Asp Pro Val Val Arg Thr 
     770                775                780
His Glu Ile Arg Ala Lys Val Lys Glu Leu Asn Asn Val Cys Glu Pro 
 785                790                795                800
Val Val Thr Gln Pro Lys Pro Lys Ile Glu Ser Pro Lys Leu Glu Arg 
                 805                810                815
Thr Pro Asn Gly Pro Asn Ile Asp Lys Lys Glu Asp Leu Glu Gly Lys 
             820                825                830
Asn Asn Leu Gly Ala Glu Arg Pro His Gln Asn Gly Glu Cys His Pro 
         835                840                845
Asn Glu Lys Gly Ser Val Asn Met Asp Leu Asp 
     850                855



<210> 11
<211> 3612
<212> DNA
<213> Homo sapiens
<308> AB003334
<400> 11

gaggaagtg  gacctcccc  tttgggtcg  tagttcagc  ccggcgccg  tgtgcgagc  60
gcggcagag  gaggcaggc  acccgaggt  cggagcgac  tgcggaggc  gagccccgc  120
ttctcccag  gtttcttat  agccagccg  cgctgtccc  gggggagta  gaggctcct  180
acaggccgc  gctgtctgt  tgtccttct  agtgtcaga  gaacggcca  accccgcgg  240
ccggagcag  acgcggcca  ggcagaaag  ggcggcagg  gaagcaggc  gggggccgg  300
ggacgcaga  cgagacccg  ggcggaggc  gaccgcgag  cggccatgt  ggtggtggg  360
ttggacgtg  gctcgcaga  ctgctacat  gcggtagcc  gggccgggg  catcgagac  420
atcgccaat  agttcagcg  ccggtgcac  ccgtcagtc  tatcatttg  atcaaaaaa  480
agaacaatc  gagttgcag  caaaaatca  caaatcact  atgcaaaca  tacggtgtc  540
aacttcaaa  gatttcatg  ccgagcatt  aacgacccc  tcattcaaa  ggagaagga  600
aacttgagt  acgatttgg  tccattgaa  aatggtgga  ttggaataa  ggtaatgta  660
atgggtgaa  aacatctat  tagtgtgga  cagataaca  ccatgttgt  gactaagct  720
aaggaaact  ctgaaaaca  cctcaagaa  ccagtaaca  attgtgtta  ttcagtccc  780
tccttcttt  cagatgctg  gaggcgatc  gtgttagat  ctgcacaga  tgttggcct  840
aactgttta  gacttatga  tgacatgac  gctgttgct  tgaattacg  aatttataa  900
caggatctc  caagcctgg  tgagaaacc  cggatagtg  tttttgttg  tatgggaca  960
tcagctttt  aagtgtctg  ttgtgcttt  aacaaggga  aattgaagg  actgggaac  1020
gcttttgat  ctttcttag  aggaaaaaa  ttcgatgaa  agttagtgg  acatttctg  1080
gcagaattt  aaactaagt  caagttgga  gcaaaatcc  aaatacgag  actcctacg  1140
ctgtatcag  aatgtgaaa  actgaaaaa  ctaatgagc  ctaacagca  agaccttcc  1200
ctgaatatc  aatgcttta  gaatgataa  gatgtttcc  gaaagatga  caggtcaca  1260
tttgaagaa  tctgtgctg  acttctgca  aagatagaa  taccccttt  ttcactgtt  1320
gaacaaact  atctcaaag  agaagatgt  agtgcagtt  agattgttg  aggcgctac  1380
cgaattcca  ctgtgaagg  aagaattgc  aaattcttt  gaaaagata  tagcacaac  1440
ctcaatgca  atgaagcag  agccagagg  tgtgcatta  agtgtgcaa  actttcccc  1500
gcatttaaa  ttagagaat  ttccgtcac  gatgcagtt  cttttccaa  atctctgat  1560
tggaaccat  attcagaag  tactgaagg  gttcatgaa  tctttagtc  aaaccatgc  1620
gctcctttc  ccaaagttc  cacctttct  agaaggggg  cttttgagc  agaagcttt  1680
tattctgat  cccaaggag  tccatatcc  gaagcaaaa  taggccgct  tgtagttca  1740
aatgtttct  cacagaaag  tggagaaaa  tctagagta  aagtcaaag  gcgagtcaa  1800
acccatggc  ttttcacca  ctctacggc  tctatggtg  agaaagtcc  aactgagga  1860
aatgaaatg  cttctgaag  tgacatgga  tgtctgaat  agagaccac  agaaaaccc  1920
gacactgat  aaaatgtcc  gcaagacaa  agtgaagct  gaacacagc  ccaggtaca  1980
actgatgct  aacaaacct  acagtctcc  ccttcacct  aacttacct  agaagaaaa  2040
aaaatccca  atgctgaca  agcaaatga  aaaaaagtt  accagcctc  agaagctaa  2100
aagcccaaa  taaaggtgg  gaatgttga  ctgcctatt  aagccaact  ggtctggca  2160
ttagggaaa  accttctta  catgtatat  gagacagag  gtaagatga  aatgcaaga  2220
aaattggaa  aagaaagga  tgatgctaa  aatgcagtt  aggaatatg  gtatgagtt  2280
agagacaag  tgtgtggac  atatgaaaa  tttatatgt  agcaggatc  tcaaaattt  2340
ttgagactc  tcacagaaa  tgaagactg  ctgtatgaa  aaggagagg  ccaagctaa  2400
caagcatat  ttgacaagt  ggaagaatt  atgaaaatt  gcactccag  taaagttcg  2460
tttcaggaa  ctgaagaac  gccaaaaat  tttgaagaa  taggacaga  gctgcagca  2520
tatgccaag  tagcagctg  cttcagaaa  aaggatgag  aatacaacc  tattgatga  2580
tctgaaatg  aaaaagtgg  gaagtctgt  aatgaagtg  tggaatgga  gaataatgt  2640
atgaatgct  aggctaaaa  gagtcttga  caggatcca  ttgtacgtg  tcaggaaat  2700
aaaacaaaa  tcaaggaat  gaacaacac  tgtgaaccc  ttgtaacac  accgaaacc  2760
aaaattgaa  cacccaaac  ggaaagaac  ccaaatggc  caaatattg  taaaaagga  2820
gaagattta  aagacaaaa  caattttgg  gctgaacct  cacatcaga  tggtgaatg  2880
taccctaat  agaaaaatt  tgttaatat  gacttggac  agataacct  aaattggcc  2940
attccttca  ttaataaaa  atttttgcc  tagtatgtg  ctctacata  catactgaa  3000
ctatttata  tttcttttt  aaggatatt  agaaatttt  tgtattata  ggaaaaaga  3060
aaaaagctt  agtctgtag  ctttatgat  ctaaaaggg  aaattgcct  ggtaacttt  3120
agattcctg  ggaattgtg  attcatact  agctttctg  gcagtctca  catttgcat  3180
actgaggat  aaactgact  ttgtctttt  gagaaaaaa  actgtactg  tgttcaaga  3240
ggctgtgat  aaaatcttt  agcatttgt  cctgccaag  tagttttct  gcattttgc  3300
ctccattca  catgtgtgt  ggtgtggat  tttataaac  agactaagt  tgacttcat  3360
agggctttc  aaaaccatt  ctgtccaag  gaaaatgac  ttttgcttt  atattaaaa  3420
ttcaatgag  aaaacaaaa  ctagtcaaa  gtgttagca  catgcagaa  aaaaacttt  3480
aactttctc  ctcactata  agtatattg  caatgtgaa  gtgtggaat  gaagaaatg  3540
cgatcctgt  gtaactgat  gtgaacact  ttatgagct  taaaataaa  ttcatctta  3600
ggtgtcatt  ct  3612



<210> 12
<211> 858
<212> PRT
<213> Homo sapiens
<308> Q92598
<400> 12

Met Ser Val Val Gly Leu Asp Val Gly Ser Gln Ser Cys Tyr Ile Ala 
  1               5                  10                  15
Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Phe Ser Asp 
             20                  25                  30
Arg Cys Thr Pro Ser Val Ile Ser Phe Gly Ser Lys Asn Arg Thr Ile 
         35                  40                  45
Gly Val Ala Ala Lys Asn Gln Gln Ile Thr His Ala Asn Asn Thr Val 
     50                  55                  60
Ser Asn Phe Lys Arg Phe His Gly Arg Ala Phe Asn Asp Pro Phe Ile 
 65                  70                  75                  80
Gln Lys Glu Lys Glu Asn Leu Ser Tyr Asp Leu Val Pro Leu Lys Asn 
                 85                  90                  95
Gly Gly Val Gly Ile Lys Val Met Tyr Met Gly Glu Glu His Leu Phe 
             100                105                110
Ser Val Glu Gln Ile Thr Ala Met Leu Leu Thr Lys Leu Lys Glu Thr 
         115                120                125
Ala Glu Asn Ser Leu Lys Lys Pro Val Thr Asp Cys Val Ile Ser Val 
     130                135                140
Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Leu Asp Ala Ala 
 145                150                155                160
Gln Ile Val Gly Leu Asn Cys Leu Arg Leu Met Asn Asp Met Thr Ala 
                 165                170                175
Val Ala Leu Asn Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ser Leu Asp 
             180                185                190
Glu Lys Pro Arg Ile Val Val Phe Val Asp Met Gly His Ser Ala Phe 
         195                200                205
Gln Val Ser Ala Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Gly 
     210                215                220
Thr Ala Phe Asp Pro Phe Leu Gly Gly Lys Asn Phe Asp Glu Lys Leu 
 225                230                235                240
Val Glu His Phe Cys Ala Glu Phe Lys Thr Lys Tyr Lys Leu Asp Ala 
                 245                250                255
Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys 
             260                265                270
Leu Lys Lys Leu Met Ser Ser Asn Ser Thr Asp Leu Pro Leu Asn Ile 
         275                280                285
Glu Cys Phe Met Asn Asp Lys Asp Val Ser Gly Lys Met Asn Arg Ser 
     290                295                300
Gln Phe Glu Glu Leu Cys Ala Glu Leu Leu Gln Lys Ile Glu Val Pro 
 305                310                315                320
Leu Tyr Ser Leu Leu Glu Gln Thr His Leu Lys Val Glu Asp Val Ser 
                 325                330                335
Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
             340                345                350
Arg Ile Ala Lys Phe Phe Gly Lys Asp Ile Ser Thr Thr Leu Asn Ala 
         355                360                365
Asp Glu Ala Val Ala Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
     370                375                380
Pro Ala Phe Lys Val Arg Glu Phe Ser Val Thr Asp Ala Val Pro Phe 
 385                390                395                400
Pro Ile Ser Leu Ile Trp Asn His Asp Ser Glu Asp Thr Glu Gly Val 
                 405                410                415
His Glu Val Phe Ser Arg Asn His Ala Ala Pro Phe Ser Lys Val Leu 
             420                425                430
Thr Phe Leu Arg Arg Gly Pro Phe Glu Leu Glu Ala Phe Tyr Ser Asp 
         435                440                445
Pro Gln Gly Val Pro Tyr Pro Glu Ala Lys Ile Gly Arg Phe Val Val 
     450                455                460
Gln Asn Val Ser Ala Gln Lys Asp Gly Glu Lys Ser Arg Val Lys Val 
 465                470                475                480
Lys Val Arg Val Asn Thr His Gly Ile Phe Thr Ile Ser Thr Ala Ser 
                 485                490                495
Met Val Glu Lys Val Pro Thr Glu Glu Asn Glu Met Ser Ser Glu Ala 
             500                505                510
Asp Met Glu Cys Leu Asn Gln Arg Pro Pro Glu Asn Pro Asp Thr Asp 
         515                520                525
Lys Asn Val Gln Gln Asp Asn Ser Glu Ala Gly Thr Gln Pro Gln Val 
     530                535                540
Gln Thr Asp Ala Gln Gln Thr Ser Gln Ser Pro Pro Ser Pro Glu Leu 
 545                550                555                560
Thr Ser Glu Glu Asn Lys Ile Pro Asp Ala Asp Lys Ala Asn Glu Lys 
                 565                570                575
Lys Val Asp Gln Pro Pro Glu Ala Lys Lys Pro Lys Ile Lys Val Val 
             580                585                590
Asn Val Glu Leu Pro Ile Glu Ala Asn Leu Val Trp Gln Leu Gly Lys 
         595                600                605
Asp Leu Leu Asn Met Tyr Ile Glu Thr Glu Gly Lys Met Ile Met Gln 
     610                615                620
Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Glu Glu 
 625                630                635                640
Tyr Val Tyr Glu Phe Arg Asp Lys Leu Cys Gly Pro Tyr Glu Lys Phe 
                 645                650                655
Ile Cys Glu Gln Asp His Gln Asn Phe Leu Arg Leu Leu Thr Glu Thr 
             660                665                670
Glu Asp Trp Leu Tyr Glu Glu Gly Glu Asp Gln Ala Lys Gln Ala Tyr 
         675                680                685
Val Asp Lys Leu Glu Glu Leu Met Lys Ile Gly Thr Pro Val Lys Val 
     690                695                700
Arg Phe Gln Glu Ala Glu Glu Arg Pro Lys Met Phe Glu Glu Leu Gly 
 705                710                715                720
Gln Arg Leu Gln His Tyr Ala Lys Ile Ala Ala Asp Phe Arg Asn Lys 
                 725                730                735
Asp Glu Lys Tyr Asn His Ile Asp Glu Ser Glu Met Lys Lys Val Glu 
             740                745                750
Lys Ser Val Asn Glu Val Met Glu Trp Met Asn Asn Val Met Asn Ala 
         755                760                765
Gln Ala Lys Lys Ser Leu Asp Gln Asp Pro Val Val Arg Ala Gln Glu 
     770                775                780
Ile Lys Thr Lys Ile Lys Glu Leu Asn Asn Thr Cys Glu Pro Val Val 
 785                790                795                800
Thr Gln Pro Lys Pro Lys Ile Glu Ser Pro Lys Leu Glu Arg Thr Pro 
                 805                810                815
Asn Gly Pro Asn Ile Asp Lys Lys Glu Glu Asp Leu Glu Asp Lys Asn 
             820                825                830
Asn Phe Gly Ala Glu Pro Pro His Gln Asn Gly Glu Cys Tyr Pro Asn 
         835                840                845
Glu Lys Asn Ser Val Asn Met Asp Leu Asp 
     850                855



<210> 13
<211> 221
<212> DNA
<213> Rattus norvegicus
<308> AA684537
<400> 13

cttggctgt  gtagccatg  cggctataa  cctnctgca  cgggcttcg  tcgccgctc  60
nacagctct  tttggccgc  gcgctggca  taggctcgg  gtcggaagt  ttntcacac  120
gagctttcc  aagactgtn  ctcctgtcc  gcacagtgg  gaccatggc  agaaactgt  180
tgtaatcaa  ccttcctta  actataacg  ccgcttcct  a  221



<210> 14
<211> 119
<212> PRT
<213> Rattus norvegicus
<308> NP_079592
<400> 14

Met Lys Phe Tyr Leu Met Leu Thr Gly Ile Pro Val Ile Ile Gly Ile 
  1               5                  10                  15
Thr Leu Val Asn Ile Phe Ile Gly Glu Ala Glu Leu Ala Glu Ile Pro 
             20                  25                  30
Glu Gly Tyr Ile Pro Glu His Trp Glu Tyr Tyr Lys His Pro Ile Ser 
         35                  40                  45
Arg Trp Ile Ala Arg Asn Phe Tyr Asp Gly Pro Glu Lys Asn Tyr Glu 
     50                  55                  60
Lys Thr Leu Ala Ile Leu Gln Ile Glu Ser Glu Lys Ala Glu Leu Arg 
 65                  70                  75                  80
Leu Lys Glu Gln Glu Val Arg Arg Leu Met Arg Ala Arg Gly Asp Gly 
                 85                  90                  95
Pro Trp Tyr Gln Phe Pro Thr Pro Glu Lys Glu Phe Ile Asp His Ser 
             100                105                110
Pro Lys Ala Thr Pro Asp Asn 
         115



<210> 15
<211> 1049
<212> DNA
<213> Homo sapiens
<308> AF047181
<400> 15

gtagccatg  cggccatga  tttgttgcg  cgggtttcg  ttactgcgg  ggcagctct  60
tctggccgg  cccttggca  tcgcctcgg  tttgggggc  tcctcactc  tggctttcc  120
aaggctgct  ctcctgttc  acacagtgg  gaccatggg  aaagactat  tgtcatcag  180
ccttctaga  tctatgaca  gcgtttttt  aagttattg  gattctaca  tgcattgac  240
gggattcca  tagcaattt  cataactct  gtgaatgta  tcattggtc  agctgaact  300
gcagaaatt  cagaaggct  tgtcccaga  cactgggaa  attataagc  tcccatatc  360
agatggatt  cccgtaatt  ctatgatag  cctgaaaag  tatatgaaa  aacaatggc  420
gtccttcag  ttgaagctg  aaaggctga  ttacgggta  aggagctgg  agtgcgaaa  480
ttgatgcat  tgagaggag  tggaccctg  tattactat  agacaattg  caaggaact  540
attgatcat  ctccgaaag  aactcctga  aattaagcc  ttttttctc  aaatacaaa  600
tatattctc  ttattggaa  ataaattaa  aaatatatt  tgtattttt  ctctccgtg  660
aaaacaaaa  agcctctga  attactgtc  ctcagtgtt  gttcagatt  aggcttttg  720
ttgaggagt  tggcttcca  tccccaaag  aggtttaaa  tgtactaat  aaaactgga  780
aaataggaa  ttgtgaacc  ctaaaattg  agcaacttt  aaaggttag  gttttattt  840
cctgacaaa  ggaagttat  gaagtctaa  aatgttaag  accagtaat  atagtattt  900
gtacaaatg  ctgtactgt  gatgtctgt  ttattgagg  gcaactcag  attttaagt  960
ccataaagt  ttgaaccaa  tctaaaatg  taactcctt  ataaacaga  tctcagtaa  1020
caaatttta  agttaaaaa  aaaaaaaaa  1049



<210> 16
<211> 189
<212> PRT
<213> Homo sapiens
<308> O43674
<400> 16

Met Ala Ala Met Ser Leu Leu Arg Arg Val Ser Val Thr Ala Val Ala 
  1               5                  10                  15
Ala Leu Ser Gly Arg Pro Leu Gly Thr Arg Leu Gly Phe Gly Gly Phe 
             20                  25                  30
Leu Thr Arg Gly Phe Pro Lys Ala Ala Ala Pro Val Arg His Ser Gly 
         35                  40                  45
Asp His Gly Lys Arg Leu Phe Val Ile Arg Pro Ser Arg Phe Tyr Asp 
     50                  55                  60
Arg Arg Phe Leu Lys Leu Leu Arg Phe Tyr Ile Ala Leu Thr Gly Ile 
 65                  70                  75                  80
Pro Val Ala Ile Phe Ile Thr Leu Val Asn Val Phe Ile Gly Gln Ala 
                 85                  90                  95
Glu Leu Ala Glu Ile Pro Glu Gly Tyr Val Pro Glu His Trp Glu Tyr 
             100                105                110
Tyr Lys His Pro Ile Ser Arg Trp Ile Ala Arg Asn Phe Tyr Asp Ser 
         115                120                125
Pro Glu Lys Ile Tyr Glu Arg Thr Met Ala Val Leu Gln Ile Glu Ala 
     130                135                140
Glu Lys Ala Glu Leu Arg Val Lys Glu Leu Glu Val Arg Lys Leu Met 
 145                150                155                160
His Val Arg Gly Asp Gly Pro Trp Tyr Tyr Tyr Glu Thr Ile Asp Lys 
                 165                170                175
Glu Leu Ile Asp His Ser Pro Lys Ala Thr Pro Asp Asn 
             180                185



<210> 17
<211> 265
<212> DNA
<213> Rattus norvegicus
<308> AA686031
<400> 17

ctctagagg  aagccatca  gttaaggat  cctgtaaaa  gggccttga  aggcctttc  60
aagtctcct  aaggatatg  tcgatcaac  ggcacagca  caagtaact  gattgaagt  120
tttgttgat  gtcagtctg  catggtgga  ccaggaacc  ctgtcctgc  ggcctgcna  180
aaggttggc  tgcaaatcc  tcgattctn  taccatgaa  ggttgtctg  agctggaaa  240
tgcaggatg  gcctgggta  agatt  265



<210> 18
<211> 727
<212> PRT
<213> Rattus norvegicus
<308> AAH06660
<400> 18

Met Leu Arg Ile Pro Ile Lys Arg Ala Leu Ile Gly Leu Ser Asn Ser 
  1               5                  10                  15
Pro Lys Gly Tyr Val Arg Thr Thr Gly Thr Ala Ala Ser Asn Leu Ile 
             20                  25                  30
Glu Val Phe Val Asp Gly Gln Ser Val Met Val Glu Pro Gly Thr Thr 
         35                  40                  45
Val Leu Gln Ala Cys Glu Lys Val Gly Met Gln Ile Pro Arg Phe Cys 
     50                  55                  60
Tyr His Glu Arg Leu Ser Val Ala Gly Asn Cys Arg Met Cys Leu Val 
 65                  70                  75                  80
Glu Ile Glu Lys Ala Pro Lys Val Val Ala Ala Cys Ala Met Pro Val 
                 85                  90                  95
Met Lys Gly Trp Asn Ile Leu Thr Asn Ser Glu Lys Ser Lys Lys Ala 
             100                105                110
Arg Glu Gly Val Met Glu Phe Leu Leu Ala Asn His Pro Leu Asp Cys 
         115                120                125
Pro Ile Cys Asp Gln Gly Gly Glu Cys Asp Leu Gln Asp Gln Ser Met 
     130                135                140
Met Phe Gly Ser Asp Arg Ser Arg Phe Leu Glu Gly Lys Arg Ala Val 
 145                150                155                160
Glu Asp Lys Asn Ile Gly Pro Leu Val Lys Thr Ile Met Thr Arg Cys 
                 165                170                175
Ile Gln Cys Thr Arg Cys Ile Arg Phe Ala Ser Glu Ile Ala Gly Val 
             180                185                190
Asp Asp Leu Gly Thr Thr Gly Arg Gly Asn Asp Met Gln Val Gly Thr 
         195                200                205
Tyr Ile Glu Lys Met Phe Met Ser Glu Leu Ser Gly Asn Val Ile Asp 
     210                215                220
Ile Cys Pro Val Gly Ala Leu Thr Ser Lys Pro Tyr Ala Phe Thr Ala 
 225                230                235                240
Arg Pro Trp Glu Thr Arg Lys Thr Glu Ser Ile Asp Val Met Asp Ala 
                 245                250                255
Val Gly Ser Asn Ile Val Val Ser Thr Arg Thr Gly Glu Val Met Arg 
             260                265                270
Ile Leu Pro Arg Met His Glu Asp Ile Asn Glu Glu Trp Ile Ser Asp 
         275                280                285
Lys Thr Arg Phe Ala Tyr Asp Gly Leu Lys Arg Gln Arg Leu Thr Glu 
     290                295                300
Pro Met Val Arg Asn Glu Lys Gly Leu Leu Thr Tyr Thr Ser Trp Glu 
 305                310                315                320
Asp Ala Leu Ser Arg Val Ala Gly Met Leu Gln Asn Phe Glu Gly Asn 
                 325                330                335
Ala Val Ala Ala Ile Ala Gly Gly Leu Val Asp Ala Glu Ala Leu Val 
             340                345                350
Ala Leu Lys Asp Leu Leu Asn Lys Val Asp Ser Asp Asn Leu Cys Thr 
         355                360                365
Glu Glu Ile Phe Pro Thr Glu Gly Ala Gly Thr Asp Leu Arg Ser Asn 
     370                375                380
Tyr Leu Leu Asn Thr Thr Ile Ala Gly Val Glu Glu Ala Asp Val Val 
 385                390                395                400
Leu Leu Val Gly Thr Asn Pro Arg Phe Glu Ala Pro Leu Phe Asn Ala 
                 405                410                415
Arg Ile Arg Lys Ser Trp Leu His Asn Asp Leu Lys Val Ala Leu Ile 
             420                425                430
Gly Ser Pro Val Asp Leu Thr Tyr Arg Tyr Asp His Leu Gly Asp Ser 
         435                440                445
Pro Lys Ile Leu Gln Asp Ile Ala Ser Gly Arg His Ser Phe Cys Glu 
     450                455                460
Val Leu Lys Asp Ala Lys Lys Pro Met Val Val Leu Gly Ser Ser Ala 
 465                470                475                480
Leu Gln Arg Asp Asp Gly Ala Ala Ile Leu Ala Ala Val Ser Asn Met 
                 485                490                495
Val Gln Lys Ile Arg Val Thr Thr Gly Val Ala Ala Glu Trp Lys Val 
             500                505                510
Met Asn Ile Leu His Arg Ile Ala Ser Gln Val Ala Ala Leu Asp Leu 
         515                520                525
Gly Tyr Lys Pro Gly Val Glu Ala Ile Arg Lys Asn Pro Pro Lys Met 
     530                535                540
Leu Phe Leu Leu Gly Ala Asp Gly Gly Cys Ile Thr Arg Gln Asp Leu 
 545                550                555                560
Pro Lys Asp Cys Phe Ile Val Tyr Gln Gly His His Gly Asp Val Gly 
                 565                570                575
Ala Pro Met Ala Asp Val Ile Leu Pro Gly Ala Ala Tyr Thr Glu Lys 
             580                585                590
Ser Ala Thr Tyr Val Asn Thr Glu Gly Arg Ala Gln Gln Thr Lys Val 
         595                600                605
Ala Val Thr Pro Pro Gly Leu Ala Arg Glu Asp Trp Lys Ile Ile Arg 
     610                615                620
Ala Leu Ser Glu Ile Ala Gly Ile Thr Leu Pro Tyr Asp Thr Leu Asp 
 625                630                635                640
Gln Val Arg Asn Arg Leu Glu Glu Val Ser Pro Asn Leu Val Arg Tyr 
                 645                650                655
Asp Asp Ile Glu Glu Thr Asn Tyr Phe Gln Gln Ala Ser Glu Leu Ala 
             660                665                670
Lys Leu Val Asn Gln Glu Val Leu Ala Asp Pro Leu Val Pro Pro Gln 
         675                680                685
Leu Thr Ile Lys Asp Phe Tyr Met Thr Asp Ser Ile Ser Arg Ala Ser 
     690                695                700
Gln Thr Met Ala Lys Cys Val Lys Ala Val Thr Glu Gly Ala Gln Ala 
 705                710                715                720
Val Glu Glu Pro Ser Ile Cys 
                 725



<210> 19
<211> 2506
<212> DNA
<213> Homo sapiens
<308> NM_005006
<400> 19

cggacagtt  agcagaaca  cctccgcgg  tccggggag  agcaatatg  taaggatac  60
tgtaagaag  gccttagta  gcctttcta  gtctcctaa  ggatgtgtt  gaacaactg  120
cacagcagc  agcaacttg  ttgaagtat  tgttgatgg  cagtctgtc  tggtggaac  180
gggaacgac  gtcctccaa  cttgtgaga  ggttggcat  cagatccct  gattctgtt  240
tcatgaaag  ttgtctgtt  ctggaaact  caggatgtg  cttgttgaa  ttgagaaag  300
ccctaaggt  gtagctgct  gtgccatgc  agtaatgaa  ggttggaat  tcctaacaa  360
ctcagaaaa  tccaaaaag  ccagggaag  tgtgatgga  ttcttatta  caaatcacc  420
attggactg  cctatttgt  accagggag  tgaatgtga  ctgcaggac  agtccatga  480
gtttggaaa  gataggagc  gatttttag  ggggaagcg  gctgtggaa  acaagaaca  540
tgggccatt  gtaaagacc  tcatgacaa  atgtataca  tgtactcgc  gcatcaggt  600
tgcaagtga  attgcagga  tagatgatt  gggaacaac  ggcagagga  atgatatgc  660
agttggcac  tacattgaa  agatgttca  gtctgaact  tctgggaat  tcattgata  720
ctgccctgt  ggtgcccta  cctctaagc  ctatgcctt  actgcccgg  cttgggaaa  780
aagaaagac  gaatccatt  atgtaatgg  tgcggttgg  agtaatatt  tggttagca  840
aagaactgg  gaagtgatg  ggattttgc  acgtatgca  gaggacatc  atgaagagt  900
gatctctga  aaaaccaga  ttgcctatg  tgggctaaa  cgtcaaaga  ttaccgagc  960
aatggtcag  aatgaaaaa  ggcttttaa  ctatacttc  tgggaggat  ctctctctc  1020
cgtagctgg  atgttgcag  gttttcaag  caaagatgt  gcagcaatt  caggtggct  1080
ggtggatgc  gaagccctg  tagctctca  agatttgct  aatagagtg  actctgaca  1140
cttatgcac  gaagaggtc  tccccactg  aggagctgg  acagatttg  gttccaatt  1200
tcttcttaa  actacaatt  ctggtgtgg  agaggcaga  gttgttctt  tggttggta  1260
aaacccacg  tttgaggca  cactgttta  tgcatggat  cgaaagagc  ggctgcata  1320
tgacttaaa  gtggccctt  taggcagtc  agtggacct  acttacaca  atgaccacc  1380
gggagactc  cccaaaatt  ttcaagaca  tgcttcggg  agccatcca  ttagccagg  1440
cctaaagga  gctaaaaaa  caatggtgg  tttaggcag  tctgcactc  aaagaaatg  1500
tggagcagc  attcttgca  ctgtttcta  cattgcaca  aagattcgg  tgactagtg  1560
tgttactgg  gattggaaa  ttatgaata  ccttcatag  attgcaagt  aagtagctg  1620
tttggacct  ggctataag  ctggggtgg  agcaattcg  aagaaccct  ccaaggtgc  1680
gtttctcct  ggagcagat  gaggttgta  cacacgaca  gatttgcca  aggattgtt  1740
cattattta  caaggacat  atggtgatg  tggggctcc  atagctgat  ttattctcc  1800
aggagctgc  tacacagag  agtctgcta  atatgtcaa  actgagggt  gagctcagc  1860
gactaaggt  gcagtgaca  ctcctggct  ggcaagaga  gactggaaa  ttataagag  1920
actctctga  attgctgga  tgactcttc  atatgatac  ctggatcaa  taaggaaca  1980
attggaaga  ttctctcct  atcttgttc  atatgatga  attgaaggg  ctaattact  2040
ccagcaagc  aatgagctc  caaagctag  gaaccagca  cttcttgct  acccacttg  2100
tccacctca  ctaactcta  aagacttct  catgacaga  tcgattagc  gagcctcac  2160
gacaatggc  aaatgtgtc  aagctgtca  agagggtgc  caggcagta  aggaaccat  2220
catatgctg  agcttctac  aggatccca  ttttgccgc  gataattaa  ggacaactg  2280
agtgcagtg  tcctttaca  gtttatttc  ttgtaaaaa  aaaataata  taatttgaa  2340
catgtaata  ttaaggtta  actatgcct  tttgaaaat  atattagtt  tcaactttg  2400
agtttgaaa  acatgtatt  tgtgtaaag  ttaaataac  aaactatgc  gatgctctt  2460
aaagcattg  taacctttg  gacgaacat  aagagatcc  taaatt  2506



<210> 20
<211> 727
<212> PRT
<213> Homo sapiens
<308> P28331
<400> 20

Met Leu Arg Ile Pro Val Arg Arg Ala Leu Val Gly Leu Ser Lys Ser 
  1               5                  10                  15
Pro Lys Gly Cys Val Arg Thr Thr Ala Thr Ala Ala Ser Asn Leu Ile 
             20                  25                  30
Glu Val Phe Val Asp Gly Gln Ser Val Met Val Glu Pro Gly Thr Thr 
         35                  40                  45
Val Leu Gln Ala Cys Glu Lys Val Gly Met Gln Ile Pro Arg Phe Cys 
     50                  55                  60
Tyr His Glu Arg Leu Ser Val Ala Gly Asn Cys Arg Met Cys Leu Val 
 65                  70                  75                  80
Glu Ile Glu Lys Ala Pro Lys Val Val Ala Ala Cys Ala Met Pro Val 
                 85                  90                  95
Met Lys Gly Trp Asn Ile Leu Thr Asn Ser Glu Lys Ser Lys Lys Ala 
             100                105                110
Arg Glu Gly Val Met Glu Phe Leu Leu Ala Asn His Pro Leu Asp Cys 
         115                120                125
Pro Ile Cys Asp Gln Gly Gly Glu Cys Asp Leu Gln Asp Gln Ser Met 
     130                135                140
Met Phe Gly Asn Asp Arg Ser Arg Phe Leu Glu Gly Lys Arg Ala Val 
 145                150                155                160
Glu Asp Lys Asn Ile Gly Pro Leu Val Lys Thr Ile Met Thr Arg Cys 
                 165                170                175
Ile Gln Cys Thr Arg Cys Ile Arg Phe Ala Ser Glu Ile Ala Gly Val 
             180                185                190
Asp Asp Leu Gly Thr Thr Gly Arg Gly Asn Asp Met Gln Val Gly Thr 
         195                200                205
Tyr Ile Glu Lys Met Phe Met Ser Glu Leu Ser Gly Asn Ile Ile Asp 
     210                215                220
Ile Cys Pro Val Gly Ala Leu Thr Ser Lys Pro Tyr Ala Phe Thr Ala 
 225                230                235                240
Arg Pro Trp Glu Thr Arg Lys Thr Glu Ser Ile Asp Val Met Asp Ala 
                 245                250                255
Val Gly Ser Asn Ile Val Val Ser Thr Arg Thr Gly Glu Val Met Arg 
             260                265                270
Ile Leu Pro Arg Met His Glu Asp Ile Asn Glu Glu Trp Ile Ser Asp 
         275                280                285
Lys Thr Arg Phe Ala Tyr Asp Gly Leu Lys Arg Gln Arg Leu Thr Glu 
     290                295                300
Pro Met Val Arg Asn Glu Lys Gly Leu Leu Thr Tyr Thr Ser Trp Glu 
 305                310                315                320
Asp Ala Leu Ser Arg Val Ala Gly Met Leu Gln Ser Phe Gln Gly Lys 
                 325                330                335
Asp Val Ala Ala Ile Ala Gly Gly Leu Val Asp Ala Glu Ala Leu Val 
             340                345                350
Ala Leu Lys Asp Leu Leu Asn Arg Val Asp Ser Asp Thr Leu Cys Thr 
         355                360                365
Glu Glu Val Phe Pro Thr Ala Gly Ala Gly Thr Asp Leu Arg Ser Asn 
     370                375                380
Tyr Leu Leu Asn Thr Thr Ile Ala Gly Val Glu Glu Ala Asp Val Val 
 385                390                395                400
Leu Leu Val Gly Thr Asn Pro Arg Phe Glu Ala Pro Leu Phe Asn Ala 
                 405                410                415
Trp Ile Arg Lys Ser Trp Leu His Asn Asp Leu Lys Val Ala Leu Ile 
             420                425                430
Gly Ser Pro Val Asp Leu Thr Tyr Thr Tyr Asp His Leu Gly Asp Ser 
         435                440                445
Pro Lys Ile Leu Gln Asp Ile Ala Ser Gly Ser His Pro Phe Ser Gln 
     450                455                460
Val Leu Lys Glu Ala Lys Lys Pro Met Val Val Leu Gly Ser Ser Ala 
 465                470                475                480
Leu Gln Arg Asn Asp Gly Ala Ala Ile Leu Ala Ala Val Ser Ser Ile 
                 485                490                495
Ala Gln Lys Ile Arg Met Thr Ser Gly Val Thr Gly Asp Trp Lys Val 
             500                505                510
Met Asn Ile Leu His Arg Ile Ala Ser Gln Val Ala Ala Leu Asp Leu 
         515                520                525
Gly Tyr Lys Pro Gly Val Glu Ala Ile Arg Lys Asn Pro Pro Lys Val 
     530                535                540
Leu Phe Leu Leu Gly Ala Asp Gly Gly Cys Ile Thr Arg Gln Asp Leu 
 545                550                555                560
Pro Lys Asp Cys Phe Ile Ile Tyr Gln Gly His His Gly Asp Val Gly 
                 565                570                575
Ala Pro Ile Ala Asp Val Ile Leu Pro Gly Ala Ala Tyr Thr Glu Lys 
             580                585                590
Ser Ala Thr Tyr Val Asn Thr Glu Gly Arg Ala Gln Gln Thr Lys Val 
         595                600                605
Ala Val Thr Pro Pro Gly Leu Ala Arg Glu Asp Trp Lys Ile Ile Arg 
     610                615                620
Ala Leu Ser Glu Ile Ala Gly Met Thr Leu Pro Tyr Asp Thr Leu Asp 
 625                630                635                640
Gln Val Arg Asn Arg Leu Glu Glu Phe Ser Pro Asn Leu Val Arg Tyr 
                 645                650                655
Asp Asp Ile Glu Gly Ala Asn Tyr Phe Gln Gln Ala Asn Glu Leu Ser 
             660                665                670
Lys Leu Val Asn Gln Gln Leu Leu Ala Asp Pro Leu Val Pro Pro Gln 
         675                680                685
Leu Thr Leu Lys Asp Phe Tyr Met Thr Asp Ser Ile Ser Arg Ala Ser 
     690                695                700
Gln Thr Met Ala Lys Cys Val Lys Ala Val Thr Glu Gly Ala Gln Ala 
 705                710                715                720
Val Glu Glu Pro Ser Ile Cys 
                 725



<210> 21
<211> 308
<212> DNA
<213> Rattus norvegicus
<308> AA686579
<400> 21

cggagaccc  cgggtgaat  caccgacac  atgtctgac  aggaggcaa  accttcaac  60
gaggactta  gagataaga  agaaggaga  tacattaaa  tcaaagtta  tggacagga  120
agcagtgag  tccatttca  agtgaaaat  acaacacat  tcaagaagc  caaagaatc  180
tactgtcaa  gacagggag  tccaatgan  tcactcagg  ttctctttg  aggtcagag  240
attgctgat  atcatactc  aaaagaact  ggaatggag  aagaagacg  gatttgaag  300
ttatcagg  308



<210> 22
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> AAC39959
<400> 22

Met Ser Asp Gln Glu Ala Lys Pro Ser Thr Glu Asp Leu Gly Asp Lys 
  1               5                  10                  15
Lys Glu Gly Glu Tyr Ile Lys Leu Lys Val Ile Gly Gln Asp Ser Ser 
             20                  25                  30
Glu Ile His Phe Lys Val Lys Met Thr Thr His Leu Lys Lys Leu Lys 
         35                  40                  45
Glu Ser Tyr Cys Gln Arg Gln Gly Val Pro Met Asn Ser Leu Arg Phe 
     50                  55                  60
Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn His Thr Pro Lys Glu Leu 
 65                  70                  75                  80
Gly Met Glu Glu Glu Asp Val Ile Glu Val Tyr Gln Glu Gln Thr Gly 
                 85                  90                  95
Gly His Ser Thr Val 
             100



<210> 23
<211> 308
<212> DNA
<213> Rattus norvegicus
<308> AA686579
<400> 23

cggagaccc  cgggtgaat  caccgacac  atgtctgac  aggaggcaa  accttcaac  60
gaggactta  gagataaga  agaaggaga  tacattaaa  tcaaagtta  tggacagga  120
agcagtgag  tccatttca  agtgaaaat  acaacacat  tcaagaagc  caaagaatc  180
tactgtcaa  gacagggag  tccaatgan  tcactcagg  ttctctttg  aggtcagag  240
attgctgat  atcatactc  aaaagaact  ggaatggag  aagaagacg  gatttgaag  300
ttatcagg  308



<210> 24
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> AAC39959
<400> 24

Met Ser Asp Gln Glu Ala Lys Pro Ser Thr Glu Asp Leu Gly Asp Lys 
  1               5                  10                  15
Lys Glu Gly Glu Tyr Ile Lys Leu Lys Val Ile Gly Gln Asp Ser Ser 
             20                  25                  30
Glu Ile His Phe Lys Val Lys Met Thr Thr His Leu Lys Lys Leu Lys 
         35                  40                  45
Glu Ser Tyr Cys Gln Arg Gln Gly Val Pro Met Asn Ser Leu Arg Phe 
     50                  55                  60
Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn His Thr Pro Lys Glu Leu 
 65                  70                  75                  80
Gly Met Glu Glu Glu Asp Val Ile Glu Val Tyr Gln Glu Gln Thr Gly 
                 85                  90                  95
Gly His Ser Thr Val 
             100



<210> 25
<211> 608
<212> DNA
<213> Rattus norvegicus
<308> AA799276
<400> 25

taataacaa  tgtacaatt  agcataagg  atcggagag  ctctccaga  aagtcggtt  60
ctttgctgc  agaagaatg  ggttctgaa  ccttatcca  gaacagaag  catcagcca  120
gtctccaca  ttctctgca  aatgttgta  cctctataa  tgtatgata  tgtaatgca  180
gccttcagt  gtaagtggc  agatcgcgc  acagtgaca  tgaaacctg  tctctaatt  240
gccctgtac  gtttgctta  ttataaatt  atttaaaac  ctacagctg  tgaatggtt  300
caacctacg  ctccggtcc  aacttcagt  gttctcctc  gtgtgcagc  agctgttcc  360
cactgtatt  ttgtaactt  tttagtgaa  tcagaagca  tagacagat  ttggtgcaa  420
acaagtatt  tgtgcattt  tcgtaataa  gtgctccgc  tcggttcag  tcctcacag  480
ttctcacag  gcatgtctg  ctgtagtct  taaatagag  tcagtgtcc  tgctgctaa  540
aggtatcga  cgcacagac  tgatttcag  taaataaat  gattctacg  taaatgggt  600
aaagaaaa  608



<210> 26
<211> 1043
<212> PRT
<213> Rattus norvegicus
<308> P11507
<400> 26

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
  1               5                  10                  15
Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
             20                  25                  30
Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
         35                  40                  45
Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
     50                  55                  60
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
 65                  70                  75                  80
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                 85                  90                  95
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
             100                105                110
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
         115                120                125
Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
     130                135                140
Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
 145                150                155                160
Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                 165                170                175
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
             180                185                190
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
         195                200                205
Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
     210                215                220
Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
 225                230                235                240
Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                 245                250                255
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
             260                265                270
Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
         275                280                285
Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
     290                295                300
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
 305                310                315                320
Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                 325                330                335
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
             340                345                350
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
         355                360                365
Leu Asp Lys Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
     370                375                380
Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val Gln Lys Asp Asp Lys 
 385                390                395                400
Pro Val Lys Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                 405                410                415
Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
             420                425                430
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
         435                440                445
Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
     450                455                460
Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
 465                470                475                480
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                 485                490                495
Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
             500                505                510
Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
         515                520                525
Val Gly Ser Thr Lys Val Pro Met Thr Pro Gly Val Lys Gln Lys Ile 
     530                535                540
Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
 545                550                555                560
Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                 565                570                575
Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
             580                585                590
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
         595                600                605
Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
     610                615                620
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
 625                630                635                640
Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                 645                650                655
Phe Asp Glu Leu Ser Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
             660                665                670
Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
         675                680                685
Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
     690                695                700
Asn Asp Ala Pro Ala Leu Lys Lys Ser Glu Ile Gly Ile Ala Met Gly 
 705                710                715                720
Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                 725                730                735
Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
             740                745                750
Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
         755                760                765
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
     770                775                780
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
 785                790                795                800
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                 805                810                815
Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
             820                825                830
Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
         835                840                845
Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
     850                855                860
Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
 865                870                875                880
Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                 885                890                895
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
             900                905                910
Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
         915                920                925
Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
     930                935                940
Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
 945                950                955                960
Leu Asn Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                 965                970                975
Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
             980                985                990
Pro Gly Lys Glu Cys Ala Gln Pro Ala Thr Lys Pro Ser Cys Ser Leu 
         995                1000                1005
Ser Ala Cys Thr Asp Gly Ile Ser Trp Pro Phe Val Leu Leu Ile Met 
     1010                1015                1020
Pro Leu Val Val Trp Val Tyr Ser Thr Asp Thr Asn Phe Ser Asp Met 
 1025                1030                1035                1040
Phe Trp Ser 
                 1045



<210> 27
<211> 4134
<212> DNA
<213> Homo sapiens
<308> M23114
<400> 27

gggtgattc  gcgcccggc  aggcggaac  ggccgcaag  ggaggaggg  agagcccgt  60
cgcgcctgg  ctcccgggg  ggcacgagc  cgcggccgg  gtgcgaggc  gaggcgagg  120
ggccgcggg  acgggaggc  aggccggcc  ggcccccga  gccatggag  acgcgcaca  180
caagacggt  gaggaggtg  tgggccact  cggcgtcaa  gagagtacg  ggctgagcc  240
ggaacaggt  aagaagctt  aggagagat  gggctccaa  gagttaccg  ctgaagaag  300
aaaaacctt  ctggaactt  tgattgagc  gtttgaaga  ttgctagtt  ggattttat  360
actggcagc  tgtatatct  ttgttttgg  ttggtttga  gaaggtgaa  aaacaatta  420
agcctttgt  gaacctttt  taattttac  catattagt  gccaatgca  ttgtgggtg  480
atggcagga  agaaatgct  aaaatgcca  cgaagccct  aaggaatat  agcctgaaa  540
gggcaaagt  tatcgacag  acagaaaga  tgtgcagcg  attaaagct  aagacatag  600
tcctggtga  attgtagaa  ttgctgttg  tgacaaagt  cctgctgat  taaggttaa  660
ttccatcaa  tctaccaca  taagagttg  ccagtcaat  ctcacaggt  aatctgtct  720
tgtcatcaa  cacactgat  ccgtccctg  cccacgagc  gtcaaccaa  ataaaaaga  780
catgctgtt  tctggtaca  acattgctg  tgggaaagc  atgggagtg  tggtagcaa  840
tggagttaa  accgaaatt  gcaagatcc  ggatgaaat  gtggcaaca  aacaggaga  900
aacacccct  cagcaaaaa  tagatgaat  tggggaaca  ctttccaaa  tcatctccc  960
tatttgcat  gcagtctgg  tcataaata  tgggcactt  aatgacccg  ttcatggag  1020
gtcctggat  agaggtgct  tttactact  taaaattgc  gtggccctg  ctgtagcag  1080
cattcctga  ggtctgcct  cagtcatca  cacctgcct  gctcttgga  ctcgcagaa  1140
ggcaaagaa  aatgccatt  ttcgaagcc  cccgtctgt  gaaaccctt  gttgtactt  1200
tgttatctg  tcagacaag  ctggtacac  tacaacaaa  cagatgtca  tctgcagga  1260
gttcattct  gacagagtg  aaggtgata  ttgttccct  aatgagttt  ccataactg  1320
atcaactta  gcacctatt  gagaagtgc  taaagatga  aaaccagtg  attgtcacc  1380
gtatgatgg  ctggtagaa  tagcaacaa  ttgtgctct  tgtaatgac  ctgctttgg  1440
ttacaatga  gcaaagggt  tgtatgaaa  agttggaga  gctacagag  ctgctctca  1500
ttgcctagt  gagaagatg  atgtatttg  taccgaatt  aagggtctt  ctaaaatag  1560
acgtgcaaa  gcctgcaac  cagtcatta  acagctgat  aaaaaggaa  tcactctag  1620
gttttcacg  gacagaaag  caatgtcgg  ttactgtac  ccaaataaa  caagcagga  1680
atcaatgag  aagatgttt  tgaagggtg  tcctgaagg  gtcattgac  ggtgcaccc  1740
cattcgagt  ggaagtact  aggttccta  gacctctgg  gtcaaacag  agatcatgt  1800
tgtcattcg  gagtggggt  gtggcagcg  cacactgcg  tgcctggcc  tggccactc  1860
tgacaaccc  ctgagaaga  aagaaatgc  ccttgagga  tctgccaac  ttattaaat  1920
tgagaccaa  ctgaccttc  ttggctgcg  gggcatgct  gatcctccg  gaatcgagg  1980
ggcctcctc  gtgaagctg  gccggcaag  aggcatccg  gtcatcatg  tcactgggg  2040
caacaaggg  actgctgtg  ccatctgtc  ccgcatcgg  atcttcggg  aggatgagg  2100
cgtgacgtc  aaagctttc  caggccggg  gtttgatga  ctcaacccc  ccgcccagc  2160
agacgcctg  ctgaacgcc  gctgttttg  tcgagttga  ccctcccac  agtctaaaa  2220
cgtagaatt  cttcagtct  ttgatgaga  tacagctat  actggcgat  gcgtgaacg  2280
tgctcctgc  ctgaagaaa  ccgagattg  cattgctat  ggctctggc  ctgcggtgg  2340
taaaaccgc  tctgagatg  tcctggcgg  tgacaactt  tccaccatt  tggctgccg  2400
tgaggaggg  cgggcaatc  acaacaaca  gaaacagtt  atccgctac  tcatctcgt  2460
caacgtcgg  gaagttgtc  gtattttcc  gacagcagc  cttggattt  ccgaggctt  2520
gattcctgt  cagctgctc  gggtcaatc  ggtgacaga  ggcctgcct  ccactgcac  2580
ggggttcaa  cctcctgat  tggacatca  gaataaacc  ccccggaac  caaaggaac  2640
attgatcag  gggtggctc  ttttccgtt  cttggctat  ggctgttac  tcggcgctg  2700
taccgtggg  gctgctgca  ggtggttca  tgctgctga  ggtggtcca  gagtgtcct  2760
ctaccagct  agtcatttc  tacagtgta  agaggacaa  ccggacttt  aaggcgtgg  2820
ttgtgcaat  tttgaatcc  catacccga  gacaatggc  ctctctgtt  tagtaacta  2880
agaaatgtg  aacgccctc  acagcttgt  cgaaaacca  tccttgctg  ggatgcccc  2940
ctgggagaa  atctggctc  tgggctcca  ctgcctgtc  atgtcactc  acttcctga  3000
cctctatgt  gaacccttg  cactcatct  ccagatcac  ccgctgaac  tgacccagt  3060
gctgatggt  ctgaaaatc  ccttgcccg  gattctcat  gatgagacg  tcaagtttg  3120
ggcccgcaa  tacctggaa  ctggtaaag  gtgtgtgca  cctgccacc  aatcctgct  3180
gttctcggc  tgcaccgat  ggatttcct  gccgtttgt  ctgctcata  tgcccctgg  3240
gatctgggt  tatagcaca  acactaact  tagcgatat  ttctggtct  gactgacag  3300
tttccataa  gaagatgtt  aacttaatc  attaatttt  ttattgttt  aagcaactg  3360
ctatttctg  tgaattttc  catgaacat  ctggctggt  atggaggtt  catactcta  3420
attttgttt  gctttttct  actccagtg  ggcaagatt  tcctttttt  tacacataa  3480
taaagtgtc  attgacatg  acagagaac  aacactatt  tatgcaaat  tttttttgt  3540
gatgaaaaa  catgtacag  gttctgttt  atactcatc  ttgtataaa  aaaatagtt  3600
agccagcag  cattgtcag  aaattaatt  gcagcagat  ttaggaaat  aatgtgtgt  3660
gtttttttt  taaaactaa  tagcatgta  tgtgtcttt  gcatgatga  ccggattta  3720
tttgatatc  cagtctaat  tttattcat  agccaattt  tctgcactg  gcagagtct  3780
gctacctca  tcagtattg  tttggtttg  tacttccct  acccacttt  gcctccgtt  3840
accccaccc  accccacct  tccccacct  acccccgcc  cgcttggct  cttctttag  3900
attgtgatg  ttcgttctg  ttacatcag  tttaacgag  ggtatgcct  tactcgctt  3960
tgcagaaaa  attgttcca  attcaatcg  ctgggttta  gtcccttca  atagttttt  4020
aggttattt  tttaaatgt  taatgtatt  tattgtaac  gacattgtt  tgccaacat  4080
gcctatttc  gtggcacgt  atctagttt  aaaaaaata  aacatttta  aaag  4134



<210> 28
<211> 1042
<212> PRT
<213> Homo sapiens
<308> P16615
<400> 28

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
  1               5                  10                  15
Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
             20                  25                  30
Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
         35                  40                  45
Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
     50                  55                  60
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
 65                  70                  75                  80
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                 85                  90                  95
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
             100                105                110
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
         115                120                125
Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
     130                135                140
Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
 145                150                155                160
Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                 165                170                175
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
             180                185                190
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
         195                200                205
Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
     210                215                220
Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
 225                230                235                240
Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                 245                250                255
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
             260                265                270
Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
         275                280                285
Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
     290                295                300
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
 305                310                315                320
Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                 325                330                335
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
             340                345                350
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
         355                360                365
Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
     370                375                380
Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
 385                390                395                400
Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                 405                410                415
Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
             420                425                430
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
         435                440                445
Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
     450                455                460
Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
 465                470                475                480
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                 485                490                495
Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
             500                505                510
Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
         515                520                525
Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
     530                535                540
Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
 545                550                555                560
Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                 565                570                575
Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
             580                585                590
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
         595                600                605
Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
     610                615                620
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
 625                630                635                640
Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                 645                650                655
Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
             660                665                670
Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
         675                680                685
Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
     690                695                700
Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
 705                710                715                720
Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                 725                730                735
Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
             740                745                750
Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
         755                760                765
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
     770                775                780
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
 785                790                795                800
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                 805                810                815
Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
             820                825                830
Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
         835                840                845
Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
     850                855                860
Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
 865                870                875                880
Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                 885                890                895
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
             900                905                910
Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
         915                920                925
Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
     930                935                940
Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
 945                950                955                960
Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                 965                970                975
Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
             980                985                990
Pro Gly Lys Glu Cys Val Gln Pro Ala Thr Lys Ser Cys Ser Phe Ser 
         995                1000                1005
Ala Cys Thr Asp Gly Ile Ser Trp Pro Phe Val Leu Leu Ile Met Pro 
     1010                1015                1020
Leu Val Ile Trp Val Tyr Ser Thr Asp Thr Asn Phe Ser Asp Met Phe 
 1025                1030                1035                1040
Trp Ser 
                 1045



<210> 29
<211> 599
<212> DNA
<213> Rattus norvegicus
<308> AA799336
<400> 29

cgtagccat  gcgtctcgt  tcctttgcg  ctgtgtccg  cgcctgcct  cggcctttg  60
gccgctgcc  cggcttccc  cgttggctt  ggcccggcc  ctcagcacc  ttctctgcc  120
tgagggaat  tggagaaga  ccgggactc  gcagcccac  ttggcgctc  cgcaggtgc  180
tggaacggt  acacatttg  gccgccagt  cagtgatgc  cccccactg  cgttagaag  240
aatcaggga  cgagttctg  atgtcttga  actctatga  aagattgac  cagaaaagc  300
ctcagtaaa  tctcatttt  tgaaggacc  gggcttaga  agtttggac  aagtggaaa  360
tattatggc  atggaagac  aatttgggt  tgaaattcc  gatatagat  cagagaagt  420
aatgtgtcc  caagaaatt  tagattaca  tgcagataa  aaggatgtg  atgactaaa  480
tatcagagc  ttcttcctc  ctgtgagga  tccagagga  acatgatgg  atcgtggcc  540
actgacagc  gttctgttc  acttgtatt  aaattgtct  agtgttttg  cctttaaaa  599



<210> 30
<211> 156
<212> PRT
<213> Rattus norvegicus
<308> BAB26840
<400> 30

Met Ala Ser Arg Val Leu Cys Ala Cys Val Arg Arg Leu Pro Ala Ala 
  1               5                  10                  15
Phe Ala Pro Leu Pro Arg Leu Pro Thr Leu Ala Leu Ala Arg Pro Leu 
             20                  25                  30
Ser Thr Thr Leu Cys Pro Glu Gly Ile Arg Arg Arg Pro Gly Ala Leu 
         35                  40                  45
Gln Ser Ala Leu Ala Leu Ala Gln Val Pro Gly Thr Val Thr His Leu 
     50                  55                  60
Cys Arg Gln Tyr Ser Asp Ala Pro Pro Leu Thr Leu Asp Gly Ile Lys 
 65                  70                  75                  80
Asp Arg Val Leu Tyr Val Leu Lys Leu Tyr Asp Lys Ile Asp Pro Glu 
                 85                  90                  95
Lys Leu Ser Val Asn Ser His Phe Met Lys Asp Leu Gly Leu Asp Ser 
             100                105                110
Leu Asp Gln Val Glu Ile Ile Met Ala Met Glu Asp Glu Phe Gly Phe 
         115                120                125
Glu Ile Pro Asp Ile Asp Ala Glu Lys Leu Met Cys Pro Gln Glu Ile 
     130                135                140
Val Asp Tyr Ile Ala Asp Lys Lys Asp Val Tyr Glu 
 145                150                155



<210> 31
<211> 663
<212> DNA
<213> Homo sapiens
<308> NM_005003
<400> 31

agtgcatcc  gggttggcg  agccatggc  tctcgtgtc  tttcagcct  tgtcagccg  60
ctgcccgcg  cctttgcgc  gctgccccg  gtccggatg  tggccgtgg  ccggcctct  120
agcactgct  tctgctccg  ggggaccca  acgaggctc  ggactttgc  gccggcctt  180
gtgctcgcg  aggttcctg  tagagttac  cagttgtgc  gccagtata  cgacatgcc  240
cctttgacg  tagagggca  ccaggaccg  gttctttac  tattgaaac  ctatgacaa  300
attgaccca  agaagcttt  agtaaattc  cattttatg  aagacctgg  cttagacag  360
ttggaccaa  tggagatta  catggccat  gaagacgaa  ttgggtttg  aattcctga  420
atagatgct  aaaagttaa  gtgtccaca  gaaattgta  attacattg  agataagaa  480
gatgtatat  aataaagta  cagaccctt  ggctttgct  agagaggac  cagatgata  540
tgacgaatg  ctggcagtg  ggacacatt  tggcattct  gctgactct  acagagtga  600
tctgatgga  ttgtattta  attgtatgt  ttttactct  tgaaaataa  tctataaaa  660
caa  663



<210> 32
<211> 156
<212> PRT
<213> Homo sapiens
<308> O14561
<400> 32

Met Ala Ser Arg Val Leu Ser Ala Tyr Val Ser Arg Leu Pro Ala Ala 
  1               5                  10                  15
Phe Ala Pro Leu Pro Arg Val Arg Met Leu Ala Val Ala Arg Pro Leu 
             20                  25                  30
Ser Thr Ala Leu Cys Ser Ala Gly Thr Gln Thr Arg Leu Gly Thr Leu 
         35                  40                  45
Gln Pro Ala Leu Val Leu Ala Gln Val Pro Gly Arg Val Thr Gln Leu 
     50                  55                  60
Cys Arg Gln Tyr Ser Asp Met Pro Pro Leu Thr Leu Glu Gly Ile Gln 
 65                  70                  75                  80
Asp Arg Val Leu Tyr Val Leu Lys Leu Tyr Asp Lys Ile Asp Pro Glu 
                 85                  90                  95
Lys Leu Ser Val Asn Ser His Phe Met Lys Asp Leu Gly Leu Asp Ser 
             100                105                110
Leu Asp Gln Val Glu Ile Ile Met Ala Met Glu Asp Glu Phe Gly Phe 
         115                120                125
Glu Ile Pro Asp Ile Asp Ala Glu Lys Leu Met Cys Pro Gln Glu Ile 
     130                135                140
Val Asp Tyr Ile Ala Asp Lys Lys Asp Val Tyr Glu 
 145                150                155



<210> 33
<211> 588
<212> DNA
<213> Rattus norvegicus
<308> AA799389
<400> 33

gatatggaa  aggaaaggg  gatcccgac  gagaagggc  ggctcctag  agagcaact  60
gggtttgac  tctttgaag  cagtgccaa  gagaacatc  gtgtgaggc  ggccttcga  120
cgtctggtg  acgccatct  cgataagat  tctgactca  tggacacag  cccctccgt  180
ctgggcgcc  ccaagacca  acggctctc  gacaccccg  cgctgctcc  gcagaactg  240
tcttgctag  caaggcccg  cctgctgtt  cccccatgt  atgcccact  ctcctctgc  300
tctctctgt  actgtctgc  ccccgaacc  caagccagc  gagttcttt  ccagcccct  360
tggttctct  cagatggcc  cagctacag  tactaactg  aggttactg  gtgggtgaa  420
actcctctt  caacagaag  ctccctctt  ggaaggagg  tcaacatag  gacttggaa  480
gaacctttt  tgcccttaa  ataaaattc  cttcattta  caagataca  ctcccacac  540
cactcctta  gggttgacc  gtgtgtaaa  tgaggccca  ctgcacag  588



<210> 34
<211> 219
<212> PRT
<213> Rattus norvegicus
<308> Q63941
<400> 34

Met Ala Ser Val Thr Asp Gly Asn Thr Gly Ile Arg Asp Ala Ser Asp 
  1               5                  10                  15
Gln Asn Phe Asp Tyr Met Phe Lys Leu Leu Ile Ile Gly Asn Ser Ser 
             20                  25                  30
Val Gly Lys Thr Ser Phe Leu Phe Arg Tyr Ala Asp Asp Thr Phe Thr 
         35                  40                  45
Pro Ala Phe Val Ser Thr Val Gly Ile Asp Phe Lys Val Lys Thr Val 
     50                  55                  60
Tyr Arg His Glu Lys Arg Val Lys Leu Gln Ile Trp Asp Thr Ala Gly 
 65                  70                  75                  80
Gln Glu Arg Tyr Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly Ala Met 
                 85                  90                  95
Gly Phe Ile Leu Met Tyr Asp Ile Thr Asn Glu Glu Ser Phe Asn Ala 
             100                105                110
Val Gln Asp Trp Ala Thr Gln Ile Lys Thr Tyr Ser Trp Asp Asn Ala 
         115                120                125
Gln Val Ile Leu Val Gly Asn Lys Cys Asp Met Glu Glu Glu Arg Val 
     130                135                140
Ile Pro Thr Glu Lys Gly Arg Leu Leu Ala Glu Gln Leu Gly Phe Asp 
 145                150                155                160
Phe Phe Glu Ala Ser Ala Lys Glu Asn Ile Ser Val Arg Gln Ala Phe 
                 165                170                175
Glu Arg Leu Val Asp Ala Ile Cys Asp Lys Met Ser Asp Ser Met Asp 
             180                185                190
Thr Asp Pro Ser Val Leu Gly Ala Ser Lys Thr Thr Arg Leu Ser Asp 
         195                200                205
Thr Pro Pro Leu Leu Gln Gln Asn Cys Ser Cys 
     210                215



<210> 35
<211> 519
<212> DNA
<213> Rattus norvegicus
<308> AA801441
<400> 35

cagaaagtt  atattcttc  actctctga  gcaacaggg  tctgagcac  aacaaaaag  60
ggcaagcct  gacccttct  gctatctgg  tccagagac  aaactatta  gatgtggga  120
gtcagtact  gcatgtgcc  tatgactct  gtgggtcat  ataattggg  acgtggagt  180
ctgttccat  ctgggggga  gtttatttt  agttgtgct  atgacaaga  cctccgtgt  240
tgggattac  agaacaagc  atgcatgaa  accctcaat  cgcatgaac  ctttgttac  300
tccttggat  tccataaga  ggcacccta  gtggttact  gcagtgtag  tcaaacagt  360
aaggtgtgg  agtgccgtt  attgagtca  atttggttc  tcctccctt  tttcctctg  420
atgcactct  atgatacca  ggttacccc  tttgagctc  gtttaaata  atattgtcc  480
ttcatgtaa  ttattctgg  tgtagattg  gcttattaa  519



<210> 36
<211> 409
<212> PRT
<213> Rattus norvegicus
<308> P43035
<400> 36

Val Leu Ser Gln Arg Gln Arg Asp Glu Leu Asn Arg Ala Ile Ala Asp 
  1               5                  10                  15
Tyr Leu Arg Ser Asn Gly Tyr Glu Glu Ala Tyr Ser Val Phe Lys Lys 
             20                  25                  30
Glu Ala Glu Leu Asp Met Asn Glu Glu Leu Asp Lys Lys Tyr Ala Gly 
         35                  40                  45
Leu Leu Glu Lys Lys Trp Thr Ser Val Ile Arg Leu Gln Lys Lys Val 
     50                  55                  60
Met Glu Leu Glu Ser Lys Leu Asn Glu Ala Lys Glu Glu Phe Thr Ser 
 65                  70                  75                  80
Gly Gly Pro Leu Gly Gln Lys Arg Asp Pro Lys Glu Trp Ile Pro Arg 
                 85                  90                  95
Pro Pro Glu Lys Tyr Ala Leu Ser Gly His Arg Ser Pro Val Thr Arg 
             100                105                110
Val Ile Phe His Pro Val Phe Ser Val Met Val Ser Ala Ser Glu Asp 
         115                120                125
Ala Thr Ile Lys Val Trp Asp Tyr Glu Thr Gly Asp Phe Glu Arg Thr 
     130                135                140
Leu Lys Gly His Thr Asp Ser Val Gln Asp Ile Ser Phe Asp His Ser 
 145                150                155                160
Gly Lys Leu Leu Ala Ser Cys Ser Ala Asp Met Thr Ile Lys Leu Trp 
                 165                170                175
Asp Phe Gln Gly Phe Glu Cys Ile Arg Thr Met His Gly His Asp His 
             180                185                190
Asn Val Ser Ser Val Ala Ile Met Pro Asn Gly Asp His Ile Val Ser 
         195                200                205
Ala Ser Arg Asp Lys Thr Ile Lys Met Trp Glu Val Gln Thr Gly Tyr 
     210                215                220
Cys Val Lys Thr Phe Thr Gly His Arg Glu Trp Val Arg Met Val Arg 
 225                230                235                240
Pro Asn Gln Asp Gly Thr Leu Ile Ala Ser Cys Ser Asn Asp Gln Thr 
                 245                250                255
Val Arg Val Trp Val Val Ala Thr Lys Glu Cys Lys Ala Glu Leu Arg 
             260                265                270
Glu His Glu His Val Val Glu Cys Ile Ser Trp Ala Pro Glu Ser Ser 
         275                280                285
Tyr Ser Ser Ile Ser Glu Ala Thr Gly Ser Glu Thr Lys Lys Ser Gly 
     290                295                300
Lys Pro Gly Pro Phe Leu Leu Ser Gly Ser Arg Asp Lys Thr Ile Lys 
 305                310                315                320
Met Trp Asp Val Ser Thr Gly Met Cys Leu Met Thr Leu Val Gly His 
                 325                330                335
Asp Asn Trp Val Arg Gly Val Leu Phe His Ser Gly Gly Lys Phe Ile 
             340                345                350
Leu Ser Cys Ala Asp Asp Lys Thr Leu Arg Val Trp Asp Tyr Lys Asn 
         355                360                365
Lys Arg Cys Met Lys Thr Leu Asn Ala His Glu His Phe Val Thr Ser 
     370                375                380
Leu Asp Phe His Lys Thr Ala Pro Tyr Val Val Thr Gly Ser Val Asp 
 385                390                395                400
Gln Thr Val Lys Val Trp Glu Cys Arg 
                 405



<210> 37
<211> 5243
<212> DNA
<213> Homo sapiens
<308> L13385
<400> 37

cggcggagg  ggcggtgca  cgctccggt  gaatgaatc  tacttgttg  atatcttct  60
gttactagt  ggattcatt  gtgaaagaa  cattttccc  tgtgtggaa  acacttagt  120
gcatattta  attataagt  cacggatca  aaagctttt  gatttccca  aggagggac  180
taccactat  tcagataag  ttgacatta  agccaagat  gtgctgtcc  agagacaac  240
agatgaact  aatcgagct  tagcagatt  tcttcgttc  aatggctat  aagaggcat  300
ttcagtttt  aaaaaggaa  ctgaattag  tgtgaatga  gaattagat  aaaagtatg  360
tggtctttt  gaaaaaaaa  ggacatctg  tattagatt  caaaagaag  ttatggaat  420
agaatcaaa  ctaaatgaa  caaaagaag  atttacgtc  ggtggacct  ttggtcaga  480
acgagaccc  aaagaatgg  ttccccgtc  gccagaaaa  tatgcattg  gtggtcaca  540
gagtccagt  actcgagtc  ttttccatc  tgtgttcag  gttatggtc  ctgcttcag  600
ggatgctac  attaaggtg  gggattatg  gactggaga  tttgaacga  ctcttaaag  660
acatacaga  tctgtacag  acatttcat  cgaccacag  ggcaagctt  tggcttcct  720
ttctgcaga  atgaccatt  aactatggg  ttttcaggg  tttgaatgc  tcagaacca  780
gcacggcca  gaccacaat  tttcttcag  agccatcat  cccaatgga  atcatatag  840
gtctgcctc  agggataaa  ctataaaaa  gtgggaagt  caaactggc  actgtgtga  900
gacattcac  ggacacaga  aatgggtac  tatggtacg  ccaaatcaa  atggcactc  960
gatagccag  tgttccaat  accagactg  gcgtgtatg  gtcgtagca  caaaggaat  1020
caaggctga  ctccgagag  atgagcatg  ggtagaatg  atttcctgg  ctccagaaa  1080
ctcatattc  tccatctct  aagcaacag  atctgagac  aaaaaaagt  gtaaacctg  1140
gccattctt  ctgtctgga  ccagagaca  gactattaa  atgtgggat  tcagtactg  1200
catgtgcct  atgaccctc  tgggtcatg  taactgggt  cgtggagtt  tgttccatt  1260
tggggggaa  tttattttg  gttgtgctg  tgacaagac  ctacgcgta  gggattaca  1320
gaacaagcg  tgcatgaag  ccctcaatg  gcatgaaca  tttgttacc  ccttggatt  1380
ccacaagac  gcaccctat  tcgtcactg  cagcgtaga  caaacagta  aagtgtggg  1440
gtgccgttg  ttgtgtctc  ttcggcccc  cctccctct  ttcctctgg  tgcactctg  1500
tgataccat  gttacccca  tgagctctg  ttaaataaa  attgtcctt  catgtaaat  1560
attctggat  tagattgag  ttattaaat  ttacacaca  agtattcat  catggtgaa  1620
ccaaattgt  tactgtaaa  ttacatacg  tgtctagaa  taccatagg  tttaaaaac  1680
tgggctggc  ttggtcaca  caggcctaa  aaggcagaa  ttgaatcaa  tgaactagg  1740
cactaaact  aatagttga  agtgtcatt  tatgttgga  tattaattc  tgtttttct  1800
tctgctatc  gttggtgcc  gacttgatg  cctcatttg  ggaaaagtg  tggttatta  1860
ggcttttcc  gaaatgtgt  tctatgtaa  atcacttaa  tgtgcttaa  aaatctcct  1920
taaggattt  agatgataa  gctacaatt  agaatcttc  gaaccatct  tgtaatgaa  1980
ggggattat  cattggaat  tttgtcatg  cacatttgc  aaatcagta  gatatattt  2040
ttttggcag  ctatcacgc  gaggctagt  gtatattta  gtaagaaaa  gactgtaaa  2100
ctcaagaaa  atctcagca  ctaatagca  ctcatttat  tcattttgg  cttaatgct  2160
tgtaaacag  tcaaaaaat  ctgtcatac  ctaagcttc  attttccac  ctggacata  2220
ttctagttg  attctccat  ctattagac  gtgtagtga  gtgacttcc  agtagaatt  2280
aatctcccc  ttgagtgtg  catggtaca  atcactatt  gtttttggt  ttttttagg  2340
atgtgcaat  tgcattaca  aatgacaga  atactgaga  ggttctgtg  gcccatttg  2400
aaggagtgg  aggaataca  cagtttgtt  ttcaacatg  atctgatat  gatttaaac  2460
gtgtttcac  tacaagttt  aaaaaaatg  cagggttta  tggagcgtg  ataaaaatg  2520
actgttttc  ccttttgtt  atatgtaaa  gtttgtaag  atatgggcc  atctgtaag  2580
gggtaagtc  gtatgtgtg  atcatacac  tcaacctcc  tgtccttag  cctgggttt  2640
tgaaaaagt  ctaaaacgg  caagtagaa  aaatgttgc  gtggaatgc  atgctttag  2700
acaaaccct  tttgatctt  atgcttctg  aaactaggt  tgactctgg  gattttttt  2760
cagccgaag  aaaatcact  ccgttatgt  cccctctaa  ttagccgct  gacatttta  2820
acaacccgg  tatgttgta  attttgacc  aaagttaca  gtaggttta  gagaatttt  2880
agccatgac  tttggagca  tattccatt  tcagttatt  ataaagaat  ccattgctt  2940
gctaaccaa  aggtttttt  tgtttccaa  agagttatt  gaaaagtta  cagaacaat  3000
agataacag  gacagttta  caaagataa  attctgaac  gcgttttat  catttgtgt  3060
ctatgtgat  ttttaaatg  cccctttag  atttaatgg  aaattggtt  ctgcaaaag  3120
caaagggtg  gagttagcg  cctgtagat  cacacagag  ctaggccgt  tattaacta  3180
aagcagctt  atgtctagc  tgtgtcttt  tgtttgttt  cttgtttgt  tttagattc  3240
tgagagatg  ctctggaag  gaaagtttt  agaactaat  gctattttt  aggacaaaa  3300
ttacatctt  agctaattc  ttaaataca  acagtaggt  aattttcag  acaatattg  3360
ctcacaacc  tgcttacat  gaaaagtct  tttccctta  ctcttctga  tggattttt  3420
tacaaaact  tggaaaata  ctttgttct  gtttgctgc  attttctgt  ctattttga  3480
aaatataaa  acatagaaa  ggtgcatct  aacatttgt  tgtacatgt  taaatgtct  3540
gtattttaa  tcattttta  catgaattg  ttaagggta  gccacaaca  ctagaaatc  3600
ctcatagat  ttgaacaat  aaggagaat  gtaccgatg  aggaggaag  aagcgtgtc  3660
tcccctgca  cacacagcg  cttgcgttg  caaaggagg  ggaaacgat  actctgtaa  3720
caaagttat  cttacttgg  agattgcca  agcctgctg  tgagttgag  taccagaca  3780
cctccatgt  agaagcagc  aacattgaa  ctcagggat  gcccacaac  gggtccaca  3840
gtaatgagc  ctgtttaat  acgaagggg  gggggagag  agtccgtct  caacctgga  3900
tcagatttg  aaaatttcc  gcactgctg  ctgacactg  cctgttgat  ccctttctg  3960
ctgtgttct  tgttttctc  gtctgctgt  taaccctgt  ccttgcctg  gataaggac  4020
atgatgagg  tactggttt  gattgtaag  agaggactt  tattaattg  tttagaggt  4080
cactgctgc  ttgtcactt  ctcaatcaa  ttggccact  aagaaataa  gagctggta  4140
aattgcatc  tcagatgat  attgactgt  tgtgtgtgt  aaaacagac  ttccagtgc  4200
acccaaata  atatctgta  cgtgcccaa  aaatcctag  tgcgctctt  agagtgcat  4260
ccatggaga  tggtttaga  accgcgtgg  gcctagttg  ctgttgtca  ggcatcttg  4320
actttagga  actaagacc  tcctggttc  tctgtgtgt  gtgtgacca  tggtgtgcc  4380
agagcacta  tctcaaaat  actagtgtt  gcaagtcgt  ccgggctgg  gagcgttcg  4440
cgtagtctt  ggaagcttt  gctttagat  taccaagcc  cgcctcccc  ctgccagtg  4500
cctgctctc  cgttcgcct  tttctgttt  tgtgtgaac  ttcccggta  tatcactcg  4560
taaataggt  ttctttaaa  ttaattaag  aaaaactat  taaaggtaa  ggatatttt  4620
ttgacatcg  tggctcgat  atccttaag  aactgaagt  aaaattgtt  aaggaaaag  4680
cacttaaat  ggttacttt  atgtccagc  gtatataag  ccagtgtgt  catctagat  4740
acgcaaaga  tctcctggt  gagaagcga  atgtaaaaa  ctggtggaa  aaggttttg  4800
atttttttt  cagtggggt  gggggaggg  aagctggat  tacaggtca  ggctggact  4860
aatgggcct  tttatcttc  cactgtatc  tggaagtag  tgcttgctt  tactgtcca  4920
ccttcaggc  tccctaaag  tcactctga  gatgttaga  acaaacaca  actcttcga  4980
ttaaagttg  tcctgacac  gacatgaag  caagccttg  tttcgtatg  acgttgctg  5040
agtggtaat  gaggaaaac  gttccccag  ttgttaaga  ttcactgaa  atattgaca  5100
aattttaaa  aatcagtaa  ggaatgtat  taatattgc  ctcgtgttt  acagtaaga  5160
ttgttgctc  cagactgtg  aaaacaaaa  ttattcatg  tttctgcat  ttaaaaaat  5220
ttattgtac  aactggtaa  ccg  5243



<210> 38
<211> 409
<212> PRT
<213> Homo sapiens
<308> P43034
<400> 38

Val Leu Ser Gln Arg Gln Arg Asp Glu Leu Asn Arg Ala Ile Ala Asp 
  1               5                  10                  15
Tyr Leu Arg Ser Asn Gly Tyr Glu Glu Ala Tyr Ser Val Phe Lys Lys 
             20                  25                  30
Glu Ala Glu Leu Asp Val Asn Glu Glu Leu Asp Lys Lys Tyr Ala Gly 
         35                  40                  45
Leu Leu Glu Lys Lys Trp Thr Ser Val Ile Arg Leu Gln Lys Lys Val 
     50                  55                  60
Met Glu Leu Glu Ser Lys Leu Asn Glu Ala Lys Glu Glu Phe Thr Ser 
 65                  70                  75                  80
Gly Gly Pro Leu Gly Gln Lys Arg Asp Pro Lys Glu Trp Ile Pro Arg 
                 85                  90                  95
Pro Pro Glu Lys Tyr Ala Leu Ser Gly His Arg Ser Pro Val Thr Arg 
             100                105                110
Val Ile Phe His Pro Val Phe Ser Val Met Val Ser Ala Ser Glu Asp 
         115                120                125
Ala Thr Ile Lys Val Trp Asp Tyr Glu Thr Gly Asp Phe Glu Arg Thr 
     130                135                140
Leu Lys Gly His Thr Asp Ser Val Gln Asp Ile Ser Phe Asp His Ser 
 145                150                155                160
Gly Lys Leu Leu Ala Ser Cys Ser Ala Asp Met Thr Ile Lys Leu Trp 
                 165                170                175
Asp Phe Gln Gly Phe Glu Cys Ile Arg Thr Met His Gly His Asp His 
             180                185                190
Asn Val Ser Ser Val Ala Ile Met Pro Asn Gly Asp His Ile Val Ser 
         195                200                205
Ala Ser Arg Asp Lys Thr Ile Lys Met Trp Glu Val Gln Thr Gly Tyr 
     210                215                220
Cys Val Lys Thr Phe Thr Gly His Arg Glu Trp Val Arg Met Val Arg 
 225                230                235                240
Pro Asn Gln Asp Gly Thr Leu Ile Ala Ser Cys Ser Asn Asp Gln Thr 
                 245                250                255
Val Arg Val Trp Val Val Ala Thr Lys Glu Cys Lys Ala Glu Leu Arg 
             260                265                270
Glu His Glu His Val Val Glu Cys Ile Ser Trp Ala Pro Glu Ser Ser 
         275                280                285
Tyr Ser Ser Ile Ser Glu Ala Thr Gly Ser Glu Thr Lys Lys Ser Gly 
     290                295                300
Lys Pro Gly Pro Phe Leu Leu Ser Gly Ser Arg Asp Lys Thr Ile Lys 
 305                310                315                320
Met Trp Asp Val Ser Thr Gly Met Cys Leu Met Thr Leu Val Gly His 
                 325                330                335
Asp Asn Trp Val Arg Gly Val Leu Phe His Ser Gly Gly Lys Phe Ile 
             340                345                350
Leu Ser Cys Ala Asp Asp Lys Thr Leu Arg Val Trp Asp Tyr Lys Asn 
         355                360                365
Lys Arg Cys Met Lys Thr Leu Asn Ala His Glu His Phe Val Thr Ser 
     370                375                380
Leu Asp Phe His Lys Thr Ala Pro Tyr Val Val Thr Gly Ser Val Asp 
 385                390                395                400
Gln Thr Val Lys Val Trp Glu Cys Arg 
                 405



<210> 39
<211> 481
<212> DNA
<213> Rattus norvegicus
<308> AA933181
<400> 39

gcacgaggc  agtcctgtg  tgccgagcg  atcccagtg  gcggcggca  gcggctgtg  60
cggcggcgg  ggcgcctcc  gggctccgg  tccggctcc  gctgttgct  ctctcggcc  120
cggcactga  ccccacagg  gatgggcag  atctgttta  taaggacgt  acggtgatt  180
aaggagaag  tgcaaccat  agctgtcaa  tcaataaga  tgatgactc  gtgattcag  240
tactgaacc  caacaggca  accatttac  tcagggact  caggccttt  aaggacagc  300
ggtttcagc  gctgaattt  tctagcagt  aactcaaag  gtcactgac  aatgtctca  360
tttcggatg  agggaggta  ttctgccag  tctacacgg  ccctccgca  aagttatac  420
accatcaca  ttctggtcc  tccacgtaa  ttgatgatc  atatccaga  agtcacggc  480
t  481



<210> 40
<211> 1329
<212> DNA
<213> Homo sapiens
<308> NM_014333
<400> 40

atggcgagt  tagtgctgc  gagcggatc  cagtgtgcg  cggcagcgg  ggcggcggc  60
cctcccggg  tccggctcc  gcttctgct  ttgctcttc  ccgccgcgg  actgatccc  120
acaggtgat  ggcagaatc  gtttacgaa  gacgtgaca  tgatcgagg  agaggttgc  180
accatcagt  gccaagtca  taagagtga  gactctgtg  ttcagctac  gaatcccaa  240
aggcagacc  tttatttca  ggacttcag  cctttgaag  acagcaggt  tcagttgct  300
aatttttct  gcagtgaac  caaagtatc  ttgacaaac  tctcaattt  tgatgaagg  360
agatacttt  gccagctct  taccgatcc  ccacaggaa  gttacacca  catcacagt  420
ctggtccca  cacgtaatc  gatgatcga  atccagaaa  acactgcgg  ggaaggtga  480
gagattgaa  tcaactgca  tgctatggc  agcaagcca  ccacgacta  caggtggtt  540
aaagggaac  cagagctaa  aggcaaatc  gaggtggaa  agtggtcag  catgtacac  600
gtgaccagt  agctgatgc  gaaggtgca  aaggaggac  atggggtcc  agtgatctg  660
caggtggag  accctgcgg  cactggaaa  ctgcagacc  agcggtatc  agaagtaca  720
tataagcct  aagtgcaca  tcagatgac  tatcctcta  aaggcttaa  ccgggaagg  780
gacgcgctt  agttaacat  tgaagccat  gggaagccc  agcctgtga  ggtaacttg  840
gtgagagtc  atgatgaaa  gcctcaaca  gccgtactg  ctgggccca  cctgttcat  900
aataaccta  acaaaacag  taatggtac  taccgctgt  aagcttcaa  catagtggg  960
aaagctcac  cggattata  gctgtatgt  tacgatccc  ccacaacta  ccctcctcc  1020
acaacaacc  ccaccacca  caccaccac  accaccacc  tccttacca  catcacaga  1080
tcccgagca  gtgaagaag  ctcgatcag  gcagtggat  atgccgtga  cggtggcgt  1140
gtggcggtg  tggtgttcg  catgctgtg  ttgctcatc  ttctggggc  ctattttgc  1200
agacacaaa  gtacatact  cactcatga  gccaaagga  ccgatgacg  agcagacgc  1260
gacacagct  taatcaatg  agaaggagg  cagaacaac  ccgaagaaa  gaaagagta  1320
ttcatctag  1329



<210> 41
<211> 442
<212> PRT
<213> Homo sapiens
<308> NP_055148
<400> 41

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
  1               5                  10                  15
Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
             20                  25                  30
Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
         35                  40                  45
Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
     50                  55                  60
Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
 65                  70                  75                  80
Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                 85                  90                  95
Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
             100                105                110
Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
         115                120                125
Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
     130                135                140
Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
 145                150                155                160
Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                 165                170                175
Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
             180                185                190
Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
         195                200                205
Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
     210                215                220
Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
 225                230                235                240
Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                 245                250                255
Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
             260                265                270
Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
         275                280                285
Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
     290                295                300
Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
 305                310                315                320
Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                 325                330                335
Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
             340                345                350
Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly Glu Glu Gly Ser 
         355                360                365
Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val Val 
     370                375                380
Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala 
 385                390                395                400
Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp 
                 405                410                415
Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn 
             420                425                430
Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
         435                440



<210> 42
<211> 506
<212> DNA
<213> Rattus norvegicus
<308> AA944073
<400> 42

cgtgttagc  gttgtttcg  cttcgagta  aatccatta  catccgacc  ccacattta  60
tctcatcac  gcagactaa  ggcaatttc  tccctttct  tctagagac  cctgcgcca  120
gagagcgaa  tggaggaag  agagaatgc  caggctgaa  cgcaagaga  gaaagatga  180
gcagaggtc  aagtaaacc  tcttgtgca  ccacgaagc  tgcgggagc  gaagtaagg  240
atgctgaag  ccggaacaa  tggatggac  gtatgctgc  gtcggtaat  agtcgcagt  300
gacccggaa  gtcacctcg  cgagatcag  tgggaaagt  actaccttc  tcacagcca  360
aacagtccc  ctggtcctc  gccctggac  tttggcatt  tgggctaat  ctgtgctct  420
gtgggcaag  gtaactcgt  tacaagaaa  cctcttgct  tcagctgaa  agtcaatgg  480
acccactga  gcatatgca  tgcggc  506



<210> 43
<211> 25
<212> PRT
<213> Rattus norvegicus
<308> P28751
<400> 43

Met Arg Ala Lys Trp Arg Lys Lys Arg Met Arg Arg Leu Lys Arg Lys 
  1               5                  10                  15
Arg Arg Lys Met Arg Gln Arg Ser Lys 
             20                  25



<210> 44
<211> 462
<212> DNA
<213> Homo sapiens
<308> BC014383
<400> 44

ggggtctct  ggccttagc  ccatttttt  ggaaacctc  gcgccatga  agccaagtg  60
aggaagaag  gaatgcgca  gctgaagcg  aaaagaaga  agatgaggc  gaggtccaa  120
taaaccgct  gcttgttgc  ccgtggagg  cacaggagc  gaaacatgg  atgccagac  180
ctggggatg  tggtacaag  tgtgggact  catgctact  tctagagct  gtctcaatg  240
atctagaac  tcatcgccc  ctgatcgcc  atcacctct  agacccacc  tgctcataa  300
caaaatgcc  atgttggtc  tctgccctg  acctgtgac  ttctggact  tttctgtgt  360
tatttgtgg  cgagtgtaa  aaccatata  taaatcacc  cttccgctt  ttagctgaa  420
aaaaaaaaa  aataaaaaa  aaaaaaaaa  aaaaaaaaa  aa  462



<210> 45
<211> 25
<212> PRT
<213> Homo sapiens
<308> P28751
<400> 45

Met Arg Ala Lys Trp Arg Lys Lys Arg Met Arg Arg Leu Lys Arg Lys 
  1               5                  10                  15
Arg Arg Lys Met Arg Gln Arg Ser Lys 
             20                  25



<210> 46
<211> 1468
<212> DNA
<213> Rattus norvegicus
<308> AB000098
<400> 46

cgcccgggc  ggtgtacca  ggcggtctc  ctcctgctg  ggggaggac  aatccgggc  60
ctgaaggct  cccttctcg  ggcaaaggt  ttccgagga  aactggctt  tacagtgcc  120
ctgtctaca  agtccgaga  taataaaaa  gcggcagga  caactagca  gacggaaag  180
gtgttcaaa  atgtggtgg  agcagagga  agggccaag  tcctagaca  tcacacagc  240
gcggcactg  ccaaaagct  ccctccacc  agttcttac  catcagtgg  gaacacagg  300
ggggctgtc  caggcctgc  gctcacaga  ttgtcaaga  agactttgg  agcgtttcc  360
cagaaagtt  cgcctccac  gcatgcctg  gcttctgac  cggaggctc  gcggcatgt  420
cagaaagtg  cgaaagatt  atcttcatc  tcctcatcc  gctcctcag  ttcagactc  480
gatggggag  aacatggct  cgacattgg  ccccgagtg  caagcaaaa  caaggcagg  540
ttttccaaa  ctgaggctt  tcgtccctc  aagaacgga  cccctaaga  cacagtttt  600
gcaaaagag  aggccaagg  gcagaagcc  cacacagat  tcacctacc  agagaagcc  660
ctgcagcct  agaagaaag  gactttcac  aagcctgta  aagatagta  agaaatcag  720
tccaagctc  tgacatcca  gccacagtc  agtgaggtt  tggagcaaa  aatgaagga  780
aaacagcac  agggaaaac  gagaccaga  aagacagga  aggaaagca  agagctgtt  840
gaagctgaa  gaattttac  cggccacag  aaagccaga  tttccacac  gcccacaac  900
ggaacacaa  aggccagcg  agaactccg  ccagccgct  cccccgagt  gggagctag  960
caggaagcc  aagggccag  gctcgaatg  aagaccgct  ctcccctgg  cagaaaaga  1020
agcctggag  agcaggtgc  agaagggag  ttccaggcg  aggaggaga  ctcaggaga  1080
cagacacta  ggagatatt  gaagacagt  cctgttgag  agaaaaata  ctttggaga  1140
agagctgga  cacaactgg  ggggacgtt  caggcgcca  ccggcgaag  cccgcccac  1200
gatgcaggc  caccccagg  agccccagg  gacacacag  agcccacac  ggttcccga  1260
tcgagtgac  ccaccacct  caagaacct  cagcatcat  agtacaacg  attcacctt  1320
ctagacctg  acctggacc  ctccaagtt  aggctgcca  agccgtctt  gggacgaga  1380
tcgccccgg  actgaactc  actcagggt  gacccccgt  tggtccctt  aattcttgc  1440
tgtgagaat  aaagtcaga  gcacaaat  1468



<210> 47
<211> 458
<212> PRT
<213> Rattus norvegicus
<308> BAA24351
<400> 47

Met Ala Val Ser Leu Leu Leu Arg Gly Gly Arg Ile Arg Ala Leu Lys 
  1               5                  10                  15
Ala Ala Leu Leu Glu Ala Lys Val Phe Arg Gly Glu Leu Ala Ser Thr 
             20                  25                  30
Val Pro Leu Ser Thr Glu Ser Glu Asn Asn Lys Lys Ala Ala Gly Pro 
         35                  40                  45
Thr Ser Lys Thr Glu Ser Val Phe Lys Asp Val Val Gly Ala Glu Glu 
     50                  55                  60
Arg Ala Lys Leu Leu Asp Thr His Thr Ala Ala Ala Leu Ser Lys Ser 
 65                  70                  75                  80
Ser Pro Pro Pro Ser Ser Tyr Pro Ser Val Glu Asn Thr Gly Gly Ala 
                 85                  90                  95
Val Ala Gly Leu Pro Leu Thr Asp Leu Ser Arg Lys Thr Leu Val Ala 
             100                105                110
Phe Pro Gln Lys Val Thr Pro Pro Pro His Ala Trp Ala Ser Asp Ser 
         115                120                125
Glu Ala Arg Arg His Val Gln Lys Val Thr Lys Asp Ser Ser Ser Ser 
     130                135                140
Ser Ser Ser Ser Ser Ser Asp Ser Asp Ser Asp Gly Glu Glu His Gly 
 145                150                155                160
Ser Asp Ile Gly Pro Arg Val Ala Ser Lys Ser Lys Ala Gly Phe Ser 
                 165                170                175
Lys Pro Glu Ala Ser Arg Pro Ser Lys Asn Gly Ala Pro Lys Ile Thr 
             180                185                190
Val Phe Ala Lys Glu Lys Ala Lys Val Gln Lys Pro His Thr Asp Val 
         195                200                205
Thr Tyr Pro Glu Lys Pro Leu Gln Pro Lys Lys Lys Gly Thr Phe Thr 
     210                215                220
Lys Pro Val Glu Asp Ser Lys Glu Ile Arg Ser Lys Leu Met Thr Ser 
 225                230                235                240
Lys Pro Gln Ser Ser Glu Val Leu Glu Gln Lys Met Lys Glu Lys Gln 
                 245                250                255
His Gln Gly Lys Arg Arg Pro Asp Lys Thr Gly Lys Glu Ser Thr Glu 
             260                265                270
Leu Phe Glu Ala Glu Gly Ile Leu Pro Gly His Arg Lys Ala Arg Val 
         275                280                285
Ser Thr Gln Pro Thr Thr Gly Thr Gln Glu Ala Ser Ala Glu Leu Arg 
     290                295                300
Pro Ala Ala Ala Pro Glu Ser Gly Ala Arg Gln Glu Ala Lys Gly Pro 
 305                310                315                320
Glu Leu Glu Trp Lys Thr Ala Ser Pro Leu Val Arg Lys Glu Ser Leu 
                 325                330                335
Glu Lys Gln Val Pro Glu Gly Ser Phe Gln Ala Glu Glu Glu Thr Ser 
             340                345                350
Gly Asp Gln Thr Leu Gly Arg Tyr Ser Lys Thr Val Pro Val Glu Glu 
         355                360                365
Lys Asn Thr Phe Gly Glu Arg Ala Gly Pro Gln Leu Glu Gly Thr Phe 
     370                375                380
Gln Ala Pro Ala Gly Glu Ala Pro Pro Thr Asp Ala Gly Pro Pro Gln 
 385                390                395                400
Glu Ala Pro Gly Asp Thr Gln Glu Pro Thr Leu Val Pro Glu Ser Ser 
                 405                410                415
Asp Thr Thr Thr Tyr Lys Asn Leu Gln His His Glu Tyr Asn Ala Phe 
             420                425                430
Thr Phe Leu Asp Leu Asn Leu Asp Leu Ser Lys Phe Arg Leu Pro Gln 
         435                440                445
Pro Ser Ser Gly Arg Glu Ser Pro Arg His 
     450                455



<210> 48
<211> 1028
<212> DNA
<213> Homo sapiens
<308> BF690363
<400> 48

aagaacggt  gaaggttca  cttcgttaa  cgagggccc  cagtgtcga  gtgactccc  60
gcctgagga  ggctgaggc  tcctgaatt  tggagagtt  gaggttgag  tctaagaag  120
tgtacgtgc  gtagtcatg  tgctgcagg  tcttgtagg  agtgttgtc  aacggctca  180
caggcactg  ggctggctc  tgtgtgccg  ctcggtcgt  ccctggcgc  gctgcatct  240
ccatggcct  gcccttggc  tcaagcttc  gcgctgctg  cttttcatg  aaaccgtgg  300
tattctcaa  aggaactgt  tccaaattg  ttggtggta  ctgatcttc  acgattgcc  360
gtccaccct  caggtggcc  tctattccc  gcgtccctg  ggtttcctt  ctgggcagg  420
gaggggccg  cttgcgctg  ggctctggc  cgggttttt  cagatgccc  tctgccgcc  480
caggaggac  ggcttgcag  tgcccctct  ctctggcct  ttctgccaa  acagcaggc  540
ctgggctgc  cgttcggtg  cgcagacta  cctgacttt  gtgtggaca  ggtaagggt  600
ctttggact  caaatggct  ttggctttc  ttatctatt  cagtttaat  tactgtctt  660
tgccattgt  ttcctttaa  ctttgcttc  agctcttca  ctacttgag  tctgggcat  720
gtggtattc  ggtctcgcc  tatccctga  cttctgatg  cttagcacg  acccgttct  780
cttggctgg  ggagacttc  ctgatcagt  catggtcac  tgcggctct  gcagcaggt  840
ttcactttc  ctgcatacg  accaccggg  ggcccgttc  aaggaagaa  gccgggttt  900
aaagccccc  ccttgtcac  ctcggagga  ctgaaacag  cgatcataa  acaggctgc  960
acaggaaca  ggatctctt  cacacgaac  acgaccgct  aacacaatt  tacacgaca  1020
gcgcataa  1028



<210> 49
<211> 1468
<212> DNA
<213> Rattus norvegicus
<308> AB000098
<400> 49

cgcccgggc  ggtgtacca  ggcggtctc  ctcctgctg  ggggaggac  aatccgggc  60
ctgaaggct  cccttctcg  ggcaaaggt  ttccgagga  aactggctt  tacagtgcc  120
ctgtctaca  agtccgaga  taataaaaa  gcggcagga  caactagca  gacggaaag  180
gtgttcaaa  atgtggtgg  agcagagga  agggccaag  tcctagaca  tcacacagc  240
gcggcactg  ccaaaagct  ccctccacc  agttcttac  catcagtgg  gaacacagg  300
ggggctgtc  caggcctgc  gctcacaga  ttgtcaaga  agactttgg  agcgtttcc  360
cagaaagtt  cgcctccac  gcatgcctg  gcttctgac  cggaggctc  gcggcatgt  420
cagaaagtg  cgaaagatt  atcttcatc  tcctcatcc  gctcctcag  ttcagactc  480
gatggggag  aacatggct  cgacattgg  ccccgagtg  caagcaaaa  caaggcagg  540
ttttccaaa  ctgaggctt  tcgtccctc  aagaacgga  cccctaaga  cacagtttt  600
gcaaaagag  aggccaagg  gcagaagcc  cacacagat  tcacctacc  agagaagcc  660
ctgcagcct  agaagaaag  gactttcac  aagcctgta  aagatagta  agaaatcag  720
tccaagctc  tgacatcca  gccacagtc  agtgaggtt  tggagcaaa  aatgaagga  780
aaacagcac  agggaaaac  gagaccaga  aagacagga  aggaaagca  agagctgtt  840
gaagctgaa  gaattttac  cggccacag  aaagccaga  tttccacac  gcccacaac  900
ggaacacaa  aggccagcg  agaactccg  ccagccgct  cccccgagt  gggagctag  960
caggaagcc  aagggccag  gctcgaatg  aagaccgct  ctcccctgg  cagaaaaga  1020
agcctggag  agcaggtgc  agaagggag  ttccaggcg  aggaggaga  ctcaggaga  1080
cagacacta  ggagatatt  gaagacagt  cctgttgag  agaaaaata  ctttggaga  1140
agagctgga  cacaactgg  ggggacgtt  caggcgcca  ccggcgaag  cccgcccac  1200
gatgcaggc  caccccagg  agccccagg  gacacacag  agcccacac  ggttcccga  1260
tcgagtgac  ccaccacct  caagaacct  cagcatcat  agtacaacg  attcacctt  1320
ctagacctg  acctggacc  ctccaagtt  aggctgcca  agccgtctt  gggacgaga  1380
tcgccccgg  actgaactc  actcagggt  gacccccgt  tggtccctt  aattcttgc  1440
tgtgagaat  aaagtcaga  gcacaaat  1468



<210> 50
<211> 458
<212> PRT
<213> Rattus norvegicus
<308> BAA24351
<400> 50

Met Ala Val Ser Leu Leu Leu Arg Gly Gly Arg Ile Arg Ala Leu Lys 
  1               5                  10                  15
Ala Ala Leu Leu Glu Ala Lys Val Phe Arg Gly Glu Leu Ala Ser Thr 
             20                  25                  30
Val Pro Leu Ser Thr Glu Ser Glu Asn Asn Lys Lys Ala Ala Gly Pro 
         35                  40                  45
Thr Ser Lys Thr Glu Ser Val Phe Lys Asp Val Val Gly Ala Glu Glu 
     50                  55                  60
Arg Ala Lys Leu Leu Asp Thr His Thr Ala Ala Ala Leu Ser Lys Ser 
 65                  70                  75                  80
Ser Pro Pro Pro Ser Ser Tyr Pro Ser Val Glu Asn Thr Gly Gly Ala 
                 85                  90                  95
Val Ala Gly Leu Pro Leu Thr Asp Leu Ser Arg Lys Thr Leu Val Ala 
             100                105                110
Phe Pro Gln Lys Val Thr Pro Pro Pro His Ala Trp Ala Ser Asp Ser 
         115                120                125
Glu Ala Arg Arg His Val Gln Lys Val Thr Lys Asp Ser Ser Ser Ser 
     130                135                140
Ser Ser Ser Ser Ser Ser Asp Ser Asp Ser Asp Gly Glu Glu His Gly 
 145                150                155                160
Ser Asp Ile Gly Pro Arg Val Ala Ser Lys Ser Lys Ala Gly Phe Ser 
                 165                170                175
Lys Pro Glu Ala Ser Arg Pro Ser Lys Asn Gly Ala Pro Lys Ile Thr 
             180                185                190
Val Phe Ala Lys Glu Lys Ala Lys Val Gln Lys Pro His Thr Asp Val 
         195                200                205
Thr Tyr Pro Glu Lys Pro Leu Gln Pro Lys Lys Lys Gly Thr Phe Thr 
     210                215                220
Lys Pro Val Glu Asp Ser Lys Glu Ile Arg Ser Lys Leu Met Thr Ser 
 225                230                235                240
Lys Pro Gln Ser Ser Glu Val Leu Glu Gln Lys Met Lys Glu Lys Gln 
                 245                250                255
His Gln Gly Lys Arg Arg Pro Asp Lys Thr Gly Lys Glu Ser Thr Glu 
             260                265                270
Leu Phe Glu Ala Glu Gly Ile Leu Pro Gly His Arg Lys Ala Arg Val 
         275                280                285
Ser Thr Gln Pro Thr Thr Gly Thr Gln Glu Ala Ser Ala Glu Leu Arg 
     290                295                300
Pro Ala Ala Ala Pro Glu Ser Gly Ala Arg Gln Glu Ala Lys Gly Pro 
 305                310                315                320
Glu Leu Glu Trp Lys Thr Ala Ser Pro Leu Val Arg Lys Glu Ser Leu 
                 325                330                335
Glu Lys Gln Val Pro Glu Gly Ser Phe Gln Ala Glu Glu Glu Thr Ser 
             340                345                350
Gly Asp Gln Thr Leu Gly Arg Tyr Ser Lys Thr Val Pro Val Glu Glu 
         355                360                365
Lys Asn Thr Phe Gly Glu Arg Ala Gly Pro Gln Leu Glu Gly Thr Phe 
     370                375                380
Gln Ala Pro Ala Gly Glu Ala Pro Pro Thr Asp Ala Gly Pro Pro Gln 
 385                390                395                400
Glu Ala Pro Gly Asp Thr Gln Glu Pro Thr Leu Val Pro Glu Ser Ser 
                 405                410                415
Asp Thr Thr Thr Tyr Lys Asn Leu Gln His His Glu Tyr Asn Ala Phe 
             420                425                430
Thr Phe Leu Asp Leu Asn Leu Asp Leu Ser Lys Phe Arg Leu Pro Gln 
         435                440                445
Pro Ser Ser Gly Arg Glu Ser Pro Arg His 
     450                455



<210> 51
<211> 1028
<212> DNA
<213> Homo sapiens
<308> BF690363
<400> 51

aagaacggt  gaaggttca  cttcgttaa  cgagggccc  cagtgtcga  gtgactccc  60
gcctgagga  ggctgaggc  tcctgaatt  tggagagtt  gaggttgag  tctaagaag  120
tgtacgtgc  gtagtcatg  tgctgcagg  tcttgtagg  agtgttgtc  aacggctca  180
caggcactg  ggctggctc  tgtgtgccg  ctcggtcgt  ccctggcgc  gctgcatct  240
ccatggcct  gcccttggc  tcaagcttc  gcgctgctg  cttttcatg  aaaccgtgg  300
tattctcaa  aggaactgt  tccaaattg  ttggtggta  ctgatcttc  acgattgcc  360
gtccaccct  caggtggcc  tctattccc  gcgtccctg  ggtttcctt  ctgggcagg  420
gaggggccg  cttgcgctg  ggctctggc  cgggttttt  cagatgccc  tctgccgcc  480
caggaggac  ggcttgcag  tgcccctct  ctctggcct  ttctgccaa  acagcaggc  540
ctgggctgc  cgttcggtg  cgcagacta  cctgacttt  gtgtggaca  ggtaagggt  600
ctttggact  caaatggct  ttggctttc  ttatctatt  cagtttaat  tactgtctt  660
tgccattgt  ttcctttaa  ctttgcttc  agctcttca  ctacttgag  tctgggcat  720
gtggtattc  ggtctcgcc  tatccctga  cttctgatg  cttagcacg  acccgttct  780
cttggctgg  ggagacttc  ctgatcagt  catggtcac  tgcggctct  gcagcaggt  840
ttcactttc  ctgcatacg  accaccggg  ggcccgttc  aaggaagaa  gccgggttt  900
aaagccccc  ccttgtcac  ctcggagga  ctgaaacag  cgatcataa  acaggctgc  960
acaggaaca  ggatctctt  cacacgaac  acgaccgct  aacacaatt  tacacgaca  1020
gcgcataa  1028



<210> 52
<211> 1468
<212> DNA
<213> Rattus norvegicus
<308> AB000098
<400> 52

cgcccgggc  ggtgtacca  ggcggtctc  ctcctgctg  ggggaggac  aatccgggc  60
ctgaaggct  cccttctcg  ggcaaaggt  ttccgagga  aactggctt  tacagtgcc  120
ctgtctaca  agtccgaga  taataaaaa  gcggcagga  caactagca  gacggaaag  180
gtgttcaaa  atgtggtgg  agcagagga  agggccaag  tcctagaca  tcacacagc  240
gcggcactg  ccaaaagct  ccctccacc  agttcttac  catcagtgg  gaacacagg  300
ggggctgtc  caggcctgc  gctcacaga  ttgtcaaga  agactttgg  agcgtttcc  360
cagaaagtt  cgcctccac  gcatgcctg  gcttctgac  cggaggctc  gcggcatgt  420
cagaaagtg  cgaaagatt  atcttcatc  tcctcatcc  gctcctcag  ttcagactc  480
gatggggag  aacatggct  cgacattgg  ccccgagtg  caagcaaaa  caaggcagg  540
ttttccaaa  ctgaggctt  tcgtccctc  aagaacgga  cccctaaga  cacagtttt  600
gcaaaagag  aggccaagg  gcagaagcc  cacacagat  tcacctacc  agagaagcc  660
ctgcagcct  agaagaaag  gactttcac  aagcctgta  aagatagta  agaaatcag  720
tccaagctc  tgacatcca  gccacagtc  agtgaggtt  tggagcaaa  aatgaagga  780
aaacagcac  agggaaaac  gagaccaga  aagacagga  aggaaagca  agagctgtt  840
gaagctgaa  gaattttac  cggccacag  aaagccaga  tttccacac  gcccacaac  900
ggaacacaa  aggccagcg  agaactccg  ccagccgct  cccccgagt  gggagctag  960
caggaagcc  aagggccag  gctcgaatg  aagaccgct  ctcccctgg  cagaaaaga  1020
agcctggag  agcaggtgc  agaagggag  ttccaggcg  aggaggaga  ctcaggaga  1080
cagacacta  ggagatatt  gaagacagt  cctgttgag  agaaaaata  ctttggaga  1140
agagctgga  cacaactgg  ggggacgtt  caggcgcca  ccggcgaag  cccgcccac  1200
gatgcaggc  caccccagg  agccccagg  gacacacag  agcccacac  ggttcccga  1260
tcgagtgac  ccaccacct  caagaacct  cagcatcat  agtacaacg  attcacctt  1320
ctagacctg  acctggacc  ctccaagtt  aggctgcca  agccgtctt  gggacgaga  1380
tcgccccgg  actgaactc  actcagggt  gacccccgt  tggtccctt  aattcttgc  1440
tgtgagaat  aaagtcaga  gcacaaat  1468



<210> 53
<211> 458
<212> PRT
<213> Rattus norvegicus
<308> BAA24351
<400> 53

Met Ala Val Ser Leu Leu Leu Arg Gly Gly Arg Ile Arg Ala Leu Lys 
  1               5                  10                  15
Ala Ala Leu Leu Glu Ala Lys Val Phe Arg Gly Glu Leu Ala Ser Thr 
             20                  25                  30
Val Pro Leu Ser Thr Glu Ser Glu Asn Asn Lys Lys Ala Ala Gly Pro 
         35                  40                  45
Thr Ser Lys Thr Glu Ser Val Phe Lys Asp Val Val Gly Ala Glu Glu 
     50                  55                  60
Arg Ala Lys Leu Leu Asp Thr His Thr Ala Ala Ala Leu Ser Lys Ser 
 65                  70                  75                  80
Ser Pro Pro Pro Ser Ser Tyr Pro Ser Val Glu Asn Thr Gly Gly Ala 
                 85                  90                  95
Val Ala Gly Leu Pro Leu Thr Asp Leu Ser Arg Lys Thr Leu Val Ala 
             100                105                110
Phe Pro Gln Lys Val Thr Pro Pro Pro His Ala Trp Ala Ser Asp Ser 
         115                120                125
Glu Ala Arg Arg His Val Gln Lys Val Thr Lys Asp Ser Ser Ser Ser 
     130                135                140
Ser Ser Ser Ser Ser Ser Asp Ser Asp Ser Asp Gly Glu Glu His Gly 
 145                150                155                160
Ser Asp Ile Gly Pro Arg Val Ala Ser Lys Ser Lys Ala Gly Phe Ser 
                 165                170                175
Lys Pro Glu Ala Ser Arg Pro Ser Lys Asn Gly Ala Pro Lys Ile Thr 
             180                185                190
Val Phe Ala Lys Glu Lys Ala Lys Val Gln Lys Pro His Thr Asp Val 
         195                200                205
Thr Tyr Pro Glu Lys Pro Leu Gln Pro Lys Lys Lys Gly Thr Phe Thr 
     210                215                220
Lys Pro Val Glu Asp Ser Lys Glu Ile Arg Ser Lys Leu Met Thr Ser 
 225                230                235                240
Lys Pro Gln Ser Ser Glu Val Leu Glu Gln Lys Met Lys Glu Lys Gln 
                 245                250                255
His Gln Gly Lys Arg Arg Pro Asp Lys Thr Gly Lys Glu Ser Thr Glu 
             260                265                270
Leu Phe Glu Ala Glu Gly Ile Leu Pro Gly His Arg Lys Ala Arg Val 
         275                280                285
Ser Thr Gln Pro Thr Thr Gly Thr Gln Glu Ala Ser Ala Glu Leu Arg 
     290                295                300
Pro Ala Ala Ala Pro Glu Ser Gly Ala Arg Gln Glu Ala Lys Gly Pro 
 305                310                315                320
Glu Leu Glu Trp Lys Thr Ala Ser Pro Leu Val Arg Lys Glu Ser Leu 
                 325                330                335
Glu Lys Gln Val Pro Glu Gly Ser Phe Gln Ala Glu Glu Glu Thr Ser 
             340                345                350
Gly Asp Gln Thr Leu Gly Arg Tyr Ser Lys Thr Val Pro Val Glu Glu 
         355                360                365
Lys Asn Thr Phe Gly Glu Arg Ala Gly Pro Gln Leu Glu Gly Thr Phe 
     370                375                380
Gln Ala Pro Ala Gly Glu Ala Pro Pro Thr Asp Ala Gly Pro Pro Gln 
 385                390                395                400
Glu Ala Pro Gly Asp Thr Gln Glu Pro Thr Leu Val Pro Glu Ser Ser 
                 405                410                415
Asp Thr Thr Thr Tyr Lys Asn Leu Gln His His Glu Tyr Asn Ala Phe 
             420                425                430
Thr Phe Leu Asp Leu Asn Leu Asp Leu Ser Lys Phe Arg Leu Pro Gln 
         435                440                445
Pro Ser Ser Gly Arg Glu Ser Pro Arg His 
     450                455



<210> 54
<211> 1028
<212> DNA
<213> Homo sapiens
<308> BF690363
<400> 54

aagaacggt  gaaggttca  cttcgttaa  cgagggccc  cagtgtcga  gtgactccc  60
gcctgagga  ggctgaggc  tcctgaatt  tggagagtt  gaggttgag  tctaagaag  120
tgtacgtgc  gtagtcatg  tgctgcagg  tcttgtagg  agtgttgtc  aacggctca  180
caggcactg  ggctggctc  tgtgtgccg  ctcggtcgt  ccctggcgc  gctgcatct  240
ccatggcct  gcccttggc  tcaagcttc  gcgctgctg  cttttcatg  aaaccgtgg  300
tattctcaa  aggaactgt  tccaaattg  ttggtggta  ctgatcttc  acgattgcc  360
gtccaccct  caggtggcc  tctattccc  gcgtccctg  ggtttcctt  ctgggcagg  420
gaggggccg  cttgcgctg  ggctctggc  cgggttttt  cagatgccc  tctgccgcc  480
caggaggac  ggcttgcag  tgcccctct  ctctggcct  ttctgccaa  acagcaggc  540
ctgggctgc  cgttcggtg  cgcagacta  cctgacttt  gtgtggaca  ggtaagggt  600
ctttggact  caaatggct  ttggctttc  ttatctatt  cagtttaat  tactgtctt  660
tgccattgt  ttcctttaa  ctttgcttc  agctcttca  ctacttgag  tctgggcat  720
gtggtattc  ggtctcgcc  tatccctga  cttctgatg  cttagcacg  acccgttct  780
cttggctgg  ggagacttc  ctgatcagt  catggtcac  tgcggctct  gcagcaggt  840
ttcactttc  ctgcatacg  accaccggg  ggcccgttc  aaggaagaa  gccgggttt  900
aaagccccc  ccttgtcac  ctcggagga  ctgaaacag  cgatcataa  acaggctgc  960
acaggaaca  ggatctctt  cacacgaac  acgaccgct  aacacaatt  tacacgaca  1020
gcgcataa  1028



<210> 55
<211> 1468
<212> DNA
<213> Rattus norvegicus
<308> AB000098
<400> 55

cgcccgggc  ggtgtacca  ggcggtctc  ctcctgctg  ggggaggac  aatccgggc  60
ctgaaggct  cccttctcg  ggcaaaggt  ttccgagga  aactggctt  tacagtgcc  120
ctgtctaca  agtccgaga  taataaaaa  gcggcagga  caactagca  gacggaaag  180
gtgttcaaa  atgtggtgg  agcagagga  agggccaag  tcctagaca  tcacacagc  240
gcggcactg  ccaaaagct  ccctccacc  agttcttac  catcagtgg  gaacacagg  300
ggggctgtc  caggcctgc  gctcacaga  ttgtcaaga  agactttgg  agcgtttcc  360
cagaaagtt  cgcctccac  gcatgcctg  gcttctgac  cggaggctc  gcggcatgt  420
cagaaagtg  cgaaagatt  atcttcatc  tcctcatcc  gctcctcag  ttcagactc  480
gatggggag  aacatggct  cgacattgg  ccccgagtg  caagcaaaa  caaggcagg  540
ttttccaaa  ctgaggctt  tcgtccctc  aagaacgga  cccctaaga  cacagtttt  600
gcaaaagag  aggccaagg  gcagaagcc  cacacagat  tcacctacc  agagaagcc  660
ctgcagcct  agaagaaag  gactttcac  aagcctgta  aagatagta  agaaatcag  720
tccaagctc  tgacatcca  gccacagtc  agtgaggtt  tggagcaaa  aatgaagga  780
aaacagcac  agggaaaac  gagaccaga  aagacagga  aggaaagca  agagctgtt  840
gaagctgaa  gaattttac  cggccacag  aaagccaga  tttccacac  gcccacaac  900
ggaacacaa  aggccagcg  agaactccg  ccagccgct  cccccgagt  gggagctag  960
caggaagcc  aagggccag  gctcgaatg  aagaccgct  ctcccctgg  cagaaaaga  1020
agcctggag  agcaggtgc  agaagggag  ttccaggcg  aggaggaga  ctcaggaga  1080
cagacacta  ggagatatt  gaagacagt  cctgttgag  agaaaaata  ctttggaga  1140
agagctgga  cacaactgg  ggggacgtt  caggcgcca  ccggcgaag  cccgcccac  1200
gatgcaggc  caccccagg  agccccagg  gacacacag  agcccacac  ggttcccga  1260
tcgagtgac  ccaccacct  caagaacct  cagcatcat  agtacaacg  attcacctt  1320
ctagacctg  acctggacc  ctccaagtt  aggctgcca  agccgtctt  gggacgaga  1380
tcgccccgg  actgaactc  actcagggt  gacccccgt  tggtccctt  aattcttgc  1440
tgtgagaat  aaagtcaga  gcacaaat  1468



<210> 56
<211> 458
<212> PRT
<213> Rattus norvegicus
<308> BAA24351
<400> 56

Met Ala Val Ser Leu Leu Leu Arg Gly Gly Arg Ile Arg Ala Leu Lys 
  1               5                  10                  15
Ala Ala Leu Leu Glu Ala Lys Val Phe Arg Gly Glu Leu Ala Ser Thr 
             20                  25                  30
Val Pro Leu Ser Thr Glu Ser Glu Asn Asn Lys Lys Ala Ala Gly Pro 
         35                  40                  45
Thr Ser Lys Thr Glu Ser Val Phe Lys Asp Val Val Gly Ala Glu Glu 
     50                  55                  60
Arg Ala Lys Leu Leu Asp Thr His Thr Ala Ala Ala Leu Ser Lys Ser 
 65                  70                  75                  80
Ser Pro Pro Pro Ser Ser Tyr Pro Ser Val Glu Asn Thr Gly Gly Ala 
                 85                  90                  95
Val Ala Gly Leu Pro Leu Thr Asp Leu Ser Arg Lys Thr Leu Val Ala 
             100                105                110
Phe Pro Gln Lys Val Thr Pro Pro Pro His Ala Trp Ala Ser Asp Ser 
         115                120                125
Glu Ala Arg Arg His Val Gln Lys Val Thr Lys Asp Ser Ser Ser Ser 
     130                135                140
Ser Ser Ser Ser Ser Ser Asp Ser Asp Ser Asp Gly Glu Glu His Gly 
 145                150                155                160
Ser Asp Ile Gly Pro Arg Val Ala Ser Lys Ser Lys Ala Gly Phe Ser 
                 165                170                175
Lys Pro Glu Ala Ser Arg Pro Ser Lys Asn Gly Ala Pro Lys Ile Thr 
             180                185                190
Val Phe Ala Lys Glu Lys Ala Lys Val Gln Lys Pro His Thr Asp Val 
         195                200                205
Thr Tyr Pro Glu Lys Pro Leu Gln Pro Lys Lys Lys Gly Thr Phe Thr 
     210                215                220
Lys Pro Val Glu Asp Ser Lys Glu Ile Arg Ser Lys Leu Met Thr Ser 
 225                230                235                240
Lys Pro Gln Ser Ser Glu Val Leu Glu Gln Lys Met Lys Glu Lys Gln 
                 245                250                255
His Gln Gly Lys Arg Arg Pro Asp Lys Thr Gly Lys Glu Ser Thr Glu 
             260                265                270
Leu Phe Glu Ala Glu Gly Ile Leu Pro Gly His Arg Lys Ala Arg Val 
         275                280                285
Ser Thr Gln Pro Thr Thr Gly Thr Gln Glu Ala Ser Ala Glu Leu Arg 
     290                295                300
Pro Ala Ala Ala Pro Glu Ser Gly Ala Arg Gln Glu Ala Lys Gly Pro 
 305                310                315                320
Glu Leu Glu Trp Lys Thr Ala Ser Pro Leu Val Arg Lys Glu Ser Leu 
                 325                330                335
Glu Lys Gln Val Pro Glu Gly Ser Phe Gln Ala Glu Glu Glu Thr Ser 
             340                345                350
Gly Asp Gln Thr Leu Gly Arg Tyr Ser Lys Thr Val Pro Val Glu Glu 
         355                360                365
Lys Asn Thr Phe Gly Glu Arg Ala Gly Pro Gln Leu Glu Gly Thr Phe 
     370                375                380
Gln Ala Pro Ala Gly Glu Ala Pro Pro Thr Asp Ala Gly Pro Pro Gln 
 385                390                395                400
Glu Ala Pro Gly Asp Thr Gln Glu Pro Thr Leu Val Pro Glu Ser Ser 
                 405                410                415
Asp Thr Thr Thr Tyr Lys Asn Leu Gln His His Glu Tyr Asn Ala Phe 
             420                425                430
Thr Phe Leu Asp Leu Asn Leu Asp Leu Ser Lys Phe Arg Leu Pro Gln 
         435                440                445
Pro Ser Ser Gly Arg Glu Ser Pro Arg His 
     450                455



<210> 57
<211> 1028
<212> DNA
<213> Homo sapiens
<308> BF690363
<400> 57

aagaacggt  gaaggttca  cttcgttaa  cgagggccc  cagtgtcga  gtgactccc  60
gcctgagga  ggctgaggc  tcctgaatt  tggagagtt  gaggttgag  tctaagaag  120
tgtacgtgc  gtagtcatg  tgctgcagg  tcttgtagg  agtgttgtc  aacggctca  180
caggcactg  ggctggctc  tgtgtgccg  ctcggtcgt  ccctggcgc  gctgcatct  240
ccatggcct  gcccttggc  tcaagcttc  gcgctgctg  cttttcatg  aaaccgtgg  300
tattctcaa  aggaactgt  tccaaattg  ttggtggta  ctgatcttc  acgattgcc  360
gtccaccct  caggtggcc  tctattccc  gcgtccctg  ggtttcctt  ctgggcagg  420
gaggggccg  cttgcgctg  ggctctggc  cgggttttt  cagatgccc  tctgccgcc  480
caggaggac  ggcttgcag  tgcccctct  ctctggcct  ttctgccaa  acagcaggc  540
ctgggctgc  cgttcggtg  cgcagacta  cctgacttt  gtgtggaca  ggtaagggt  600
ctttggact  caaatggct  ttggctttc  ttatctatt  cagtttaat  tactgtctt  660
tgccattgt  ttcctttaa  ctttgcttc  agctcttca  ctacttgag  tctgggcat  720
gtggtattc  ggtctcgcc  tatccctga  cttctgatg  cttagcacg  acccgttct  780
cttggctgg  ggagacttc  ctgatcagt  catggtcac  tgcggctct  gcagcaggt  840
ttcactttc  ctgcatacg  accaccggg  ggcccgttc  aaggaagaa  gccgggttt  900
aaagccccc  ccttgtcac  ctcggagga  ctgaaacag  cgatcataa  acaggctgc  960
acaggaaca  ggatctctt  cacacgaac  acgaccgct  aacacaatt  tacacgaca  1020
gcgcataa  1028



<210> 58
<211> 4514
<212> DNA
<213> Rattus norvegicus
<308> AB000216
<400> 58

tgaagtttg  ggagcgctt  ctcaccggc  ggtccggga  gatagccgg  gcctcgctc  60
tcggtgacc  ccccattct  tcgggattc  ttctctgtg  tgacggacg  tctagacgc  120
cggtaaggg  agctgaggc  ggcggcggg  gttcagagg  ggagcgcgg  gaggttgct  180
gctgacagc  gcgcggctg  acgcggacg  cgtcgggct  tggccggct  agagcttcg  240
ccaccttcc  cgcggcctg  gcgcaggcg  tgctgcggc  ccgaggcgc  gcgcggcga  300
cagggaggg  gcctccgag  gcctagagc  ggtttccgt  ctcttcccc  gggcaagtg  360
gcatggaac  gtgagagcc  ctcgctcgg  gaggccgcg  gcggaggct  cccatggcc  420
ggacgtaca  ctccacatt  aagactctg  aggacttga  cttggactc  gggtatggg  480
ccggcgact  ctgccgctc  ctcagcctt  cgtcttcca  gtccaactc  caggcgctc  540
actcttcgg  gccgcagca  cgcggggcg  cctggtggt  ctactccgg  tccatgaac  600
gccgccaca  cagctggga  accgtgaac  cagtgctgc  cgaggatcc  gaagtggcc  660
acctcttct  gcgctgccc  cggctcccg  agctagagg  gttcccttg  accgaggga  720
acgtggctc  ggtgctccg  aaaagcgtc  gcggccgga  gctgccctc  ttctccgcc  780
aggctgtga  gcgcttggc  ggactcctc  gccgggcgc  catccgcgt  gcccgggag  840
cgcagcgcc  aagcgtgct  cacgccaag  gtacccgct  cgaggtgca  agtgcggtg  900
gcctggtgc  cagctgggc  ctggccgag  gctgcgcgc  ggcagcggt  aaggcgttg  960
ccctctata  catgagcgc  ggcgatggg  tgcgccgcg  caagtcggc  cgctgcggc  1020
tcactttct  cgtgggccg  ttcttccgt  ggatggtgg  cactcgcat  tccgtgcgc  1080
tccatgagt  tgcggccat  tcgcttacg  cttgcatgg  gaacttggt  gaggagatc  1140
gggctaggg  cctggcgag  cagagccct  atggcggag  ggcaggagg  ggagaggta  1200
ccgctgagg  cttggagat  gtcatcaac  acgatgccg  gctctgggg  gtcctgcaa  1260
cctatgagc  tctcatctg  ggcaagaac  ccaatggtg  cctctccct  cctgcctac  1320
tcagtccct  caatggtgg  tccctgggc  atgatgagc  agcagatgc  tatgctcag  1380
tggagcttc  gacactgga  cagtcactc  tggctacct  tgtgggcag  atctccgag  1440
tgagtgatc  ggtctctcg  gccatgcac  acatgcagg  gcgccaccc  ctgtgccca  1500
gcaccagcc  tgctcgcca  gcccgccag  caccacagc  catcacatg  tcccccgat  1560
ctctccata  actctacta  ttcctgaga  gtccacaga  ggagtccat  gagaacccc  1620
acctggatc  cccaagaat  accctgaat  atgaacggc  cttcatgct  ctgccacca  1680
tgatggagt  gatgcgggt  gcaatcacc  atgcagaac  ccgtcgcag  ctcactgtg  1740
acagtggcg  tatccggca  gcagcccgg  tgctgctac  aggcctgga  tgcgagccc  1800
gccagctca  acccgagtg  tgcttcagt  ccttccgga  gctggacgc  cgagctgct  1860
ctgaacgct  caaccagga  ctgggcttc  gcatgctca  ctgtgggag  acagacctc  1920
tcagccagc  atcgagccc  gggccagac  gggtgaaca  aatggatga  cagggtctg  1980
caccgctaa  gtacgcctg  gctactggg  atgaagcca  ggtccagat  ctcatcgat  2040
ctggagcaa  cttggatat  caggtccca  gcaactctc  caggcatcc  tctgtccat  2100
cagacagca  gcactggac  tccctgaca  tcgcggtgc  gcacggaca  atctctgta  2160
tgcagctgc  acttgatgc  ggtgcccat  tggagggct  ggccgtgaa  agtggggag  2220
acagctatg  cgagacacc  cttcagctg  cctctgcag  cgggaacta  gagctggtg  2280
gcttgctac  gagccgagg  gccgacccc  tcctcagca  gctggaagc  aatggcatg  2340
cttcttccc  ccatgagga  atgaactgc  tcagccact  agctgccca  ggccacagg  2400
atgtcttga  gaagctcct  actcagcca  agcaggcta  agcagatgt  ctgtcccta  2460
aagagatct  ggctgaggg  gtggaggaa  gcgacacat  gagccaggg  agtagcgag  2520
ggcctgtga  gttaagccg  acccgaacg  aggccctgc  ggaagccat  tactacagt  2580
ctgaacacg  ctacgtgga  atcacgatg  agctgaggg  actaggtgt  ccctggaag  2640
tgcacatct  gatagagtc  ctgcggacc  ctttctcac  gtcacggta  tcggtggtg  2700
agggcctcc  gagagattt  agctccatc  aggaggagg  gtacaatga  gagctggtg  2760
cagaaggct  gcagctcat  tttgacatc  tcaagacca  caaaaatga  tccgtcctc  2820
agcagctgg  caccatctt  actcactgc  atggcacca  ccccatccc  agcatcccg  2880
agatccgga  gaccctgcc  gccaggcta  atcctcact  tctgaacaa  aaggagatg  2940
ctgatgtaa  cttcctcgt  gaaggaaag  tgttttatg  acacaaagt  cttttggtg  3000
cagcatcta  caggttcaa  accttaatg  ccaataagt  agagcaaga  ggggacaac  3060
gcaaaacca  tgagatcag  gacatcaag  accacatct  tcagatgct  atgcagtac  3120
tgtactatg  aggaacaga  tccatggag  tccccacgg  tgacatcct  cagctcctg  3180
cagctgcca  cctgttcca  ctagatgcc  tgcagagac  ctgtgagat  ctgtgctcc  3240
agaccctta  tgtggagag  gctgtcaac  cctacaaat  cgccaagat  cacaacgcc  3300
cagagctgg  cctcttctg  gaaggcttc  tcctcaagc  catgaaggc  ctgctggag  3360
agatgcctt  cggcagctc  tctatggcc  aagcagcaa  gtccagggc  tggacccac  3420
gcaggatct  cagagcacc  tagctgagc  agtacattc  gtctacgtc  cctcccggg  3480
gtgagccag  gtggatggt  actgctatc  gagggtgta  aaaggtctg  taaagccag  3540
aaccaccag  gacaccccc  gtggaggga  gcttgtagg  cttctgggg  aggctctcg  3600
ggggtacgt  ctgctcttc  cctagatta  cctctgtgg  gttgactga  cctgaggtg  3660
aaggagagt  cacttcact  ttgctcggc  agtaactgg  aggggtgtg  cgtaattgc  3720
ccctgaggg  taccctgtg  cctctcccc  ccagtggct  agcgtcgag  cgatccacc  3780
cagcaccag  catcctggc  ggggatgtt  ggatcacag  cattcttat  aatgtagaa  3840
gtgtccgag  ccaggccac  gggtgcagg  gccgctatg  ttggtttcc  aacagagag  3900
ggctaagtc  tgccctcca  gctgtgcct  tgaaagggc  gggccctgt  ggtgaaaac  3960
agacctcca  tgccctccc  acaagacta  taacgagag  ctgaactgg  aatccctga  4020
caccgggta  gctgggcta  aggagctgg  agccacagg  ggcccagcc  catcatgtc  4080
gtaggctga  gcagcaggg  ttcaatggc  tcaagtgca  ggcgccttc  actcagggc  4140
ggggtgcaa  agcacactt  tcacctggg  tccgtgact  tggggcatg  acggacagg  4200
ccttggtgg  agagaagct  tgtcctctc  cctcctgtc  tcagtcttg  ctccccatc  4260
tctgacctg  ttgtggaca  acgctggga  acgatcaag  acagctacc  tagaaacta  4320
ttattcatc  gaagccccc  gggcttgca  tcctggaac  atattttca  cttgctgct  4380
gtgctggat  tacaaaaga  tgaatggta  tttattgct  taatattgt  tgatactgt  4440
actatacct  aatgttgtt  cttactgta  atgtactat  gttttatca  caataaaca  4500
tcattaaca  tgac  4514



<210> 59
<211> 1009
<212> PRT
<213> Rattus norvegicus
<308> BAA19969
<400> 59

Met Ala Gly Thr Tyr Ser Ser Thr Leu Lys Thr Leu Glu Asp Leu Thr 
  1               5                  10                  15
Leu Asp Ser Gly Tyr Gly Ala Gly Asp Ser Cys Arg Ser Leu Ser Leu 
             20                  25                  30
Ser Ser Ser Lys Ser Asn Ser Gln Ala Leu Asn Ser Ser Ala Pro Gln 
         35                  40                  45
His Arg Gly Ala Ala Trp Trp Cys Tyr Ser Gly Ser Met Asn Ser Arg 
     50                  55                  60
His Asn Ser Trp Asp Thr Val Asn Thr Val Leu Pro Glu Asp Pro Glu 
 65                  70                  75                  80
Val Ala Asp Leu Phe Ser Arg Cys Pro Arg Leu Pro Glu Leu Glu Glu 
                 85                  90                  95
Phe Pro Trp Thr Glu Gly Asp Val Ala Arg Val Leu Arg Lys Ser Val 
             100                105                110
Gly Gly Arg Arg Leu Pro Ser Phe Ser Ala Glu Ala Val Arg Arg Leu 
         115                120                125
Ala Gly Leu Leu Arg Arg Ala Leu Ile Arg Val Ala Arg Glu Ala Gln 
     130                135                140
Arg Leu Ser Val Leu His Ala Lys Cys Thr Arg Phe Glu Val Gln Ser 
 145                150                155                160
Ala Val Arg Leu Val His Ser Trp Ala Leu Ala Glu Ser Cys Ala Leu 
                 165                170                175
Ala Ala Val Lys Ala Leu Ser Leu Tyr Ser Met Ser Ala Gly Asp Gly 
             180                185                190
Leu Arg Arg Gly Lys Ser Ala Arg Cys Gly Leu Thr Phe Ser Val Gly 
         195                200                205
Arg Phe Phe Arg Trp Met Val Asp Thr Arg Ile Ser Val Arg Ile His 
     210                215                220
Glu Tyr Ala Ala Ile Ser Leu Thr Ala Cys Met Glu Asn Leu Val Glu 
 225                230                235                240
Glu Ile Arg Ala Arg Val Leu Ala Ser Gln Ser Pro Asp Gly Gly Gly 
                 245                250                255
Ala Gly Gly Gly Glu Val Ser Ala Glu Ala Leu Glu Met Val Ile Asn 
             260                265                270
Asn Asp Ala Glu Leu Trp Gly Val Leu Gln Pro Tyr Glu His Leu Ile 
         275                280                285
Cys Gly Lys Asn Ala Asn Gly Val Leu Ser Leu Pro Ala Tyr Phe Ser 
     290                295                300
Pro Tyr Asn Gly Gly Ser Leu Gly His Asp Glu Arg Ala Asp Ala Tyr 
 305                310                315                320
Ala Gln Leu Glu Leu Arg Thr Leu Glu Gln Ser Leu Leu Ala Thr Cys 
                 325                330                335
Val Gly Ser Ile Ser Glu Leu Ser Asp Leu Val Ser Arg Ala Met His 
             340                345                350
His Met Gln Gly Arg His Pro Leu Cys Pro Gly Thr Ser Pro Ala Arg 
         355                360                365
Gln Ala Arg Gln Pro Pro Gln Pro Ile Thr Trp Ser Pro Asp Ala Leu 
     370                375                380
His Thr Leu Tyr Tyr Phe Leu Arg Cys Pro Gln Met Glu Ser Met Glu 
 385                390                395                400
Asn Pro Asn Leu Asp Pro Pro Arg Met Thr Leu Asn Asn Glu Arg Pro 
                 405                410                415
Phe Met Leu Leu Pro Pro Leu Met Glu Trp Met Arg Val Ala Ile Thr 
             420                425                430
Tyr Ala Glu His Arg Arg Ser Leu Thr Val Asp Ser Gly Asp Ile Arg 
         435                440                445
Gln Ala Ala Arg Leu Leu Leu Pro Gly Leu Asp Cys Glu Pro Arg Gln 
     450                455                460
Leu Lys Pro Glu Cys Cys Phe Ser Ser Phe Arg Arg Leu Asp Ala Arg 
 465                470                475                480
Ala Ala Thr Glu Arg Phe Asn Gln Asp Leu Gly Phe Arg Met Leu Asn 
                 485                490                495
Cys Gly Arg Thr Asp Leu Ile Ser Gln Pro Ser Ser Pro Gly Pro Asp 
             500                505                510
Gly Val Asn Thr Met Asp Asp Gln Gly Leu Thr Pro Leu Met Tyr Ala 
         515                520                525
Cys Ala Thr Gly Asp Glu Ala Met Val Gln Met Leu Ile Asp Ala Gly 
     530                535                540
Ala Asn Leu Asp Ile Gln Val Pro Ser Asn Ser Pro Arg His Pro Ser 
 545                550                555                560
Val His Pro Asp Ser Arg His Trp Thr Ser Leu Thr Phe Ala Val Leu 
                 565                570                575
His Gly His Ile Ser Val Val Gln Leu Leu Leu Asp Ala Gly Ala His 
             580                585                590
Val Glu Gly Ser Ala Val Asn Ser Gly Glu Asp Ser Tyr Ala Glu Thr 
         595                600                605
Pro Leu Gln Leu Ala Ser Ala Ala Gly Asn Tyr Glu Leu Val Ser Leu 
     610                615                620
Leu Leu Ser Arg Gly Ala Asp Pro Leu Leu Ser Met Leu Glu Ala Asn 
 625                630                635                640
Gly Met Ala Ser Ser Leu His Glu Asp Met Asn Cys Phe Ser His Ser 
                 645                650                655
Ala Ala His Gly His Arg Asn Val Leu Arg Lys Leu Leu Thr Gln Pro 
             660                665                670
Gln Gln Ala Lys Ala Asp Val Leu Ser Leu Glu Glu Ile Leu Ala Glu 
         675                680                685
Gly Val Glu Glu Ser Asp Thr Ser Ser Gln Gly Ser Ser Glu Gly Pro 
     690                695                700
Val Arg Leu Ser Arg Thr Arg Thr Lys Ala Leu Gln Glu Ala Met Tyr 
 705                710                715                720
Tyr Ser Ala Glu His Gly Tyr Val Asp Ile Thr Met Glu Leu Arg Ala 
                 725                730                735
Leu Gly Val Pro Trp Lys Leu His Ile Trp Ile Glu Ser Leu Arg Thr 
             740                745                750
Ser Phe Ser Gln Ser Arg Tyr Ser Val Val Gln Gly Leu Leu Arg Asp 
         755                760                765
Phe Ser Ser Ile Lys Glu Glu Glu Tyr Asn Glu Glu Leu Val Thr Glu 
     770                775                780
Gly Leu Gln Leu Met Phe Asp Ile Leu Lys Thr Ser Lys Asn Asp Ser 
 785                790                795                800
Val Leu Gln Gln Leu Ala Thr Ile Phe Thr His Cys Tyr Gly Thr Ser 
                 805                810                815
Pro Ile Pro Ser Ile Pro Glu Ile Arg Lys Thr Leu Pro Ala Arg Leu 
             820                825                830
Asp Pro His Phe Leu Asn Asn Lys Glu Met Ser Asp Val Thr Phe Leu 
         835                840                845
Val Glu Gly Lys Leu Phe Tyr Ala His Lys Val Leu Leu Val Thr Ala 
     850                855                860
Ser Asn Arg Phe Lys Thr Leu Met Thr Asn Lys Ser Glu Gln Asp Gly 
 865                870                875                880
Asp Asn Ser Lys Thr Ile Glu Ile Ser Asp Ile Lys Tyr His Ile Phe 
                 885                890                895
Gln Met Leu Met Gln Tyr Leu Tyr Tyr Gly Gly Thr Glu Ser Met Glu 
             900                905                910
Ile Pro Thr Ala Asp Ile Leu Gln Leu Leu Ser Ala Ala Asn Leu Phe 
         915                920                925
Gln Leu Asp Ala Leu Gln Arg His Cys Glu Ile Leu Cys Ser Gln Thr 
     930                935                940
Leu Ser Val Glu Ser Ala Val Asn Thr Tyr Lys Tyr Ala Lys Ile His 
 945                950                955                960
Asn Ala Pro Glu Leu Ala Leu Phe Cys Glu Gly Phe Phe Leu Lys His 
                 965                970                975
Met Lys Ala Leu Leu Glu Gln Met Pro Ser Gly Ser Ser Ser Met Ala 
             980                985                990
Glu Ala Ala Lys Ser Arg Ala Trp Thr His Cys Arg Ile Cys Arg Ala 
         995                1000                1005
Pro 
     1010



<210> 60
<211> 313
<212> DNA
<213> Homo sapiens
<308> AA281565
<400> 60

caatgttaa  gagtgttta  tgttgataa  accatagca  atttacagt  agtaacaac  60
ttaaggtat  gttacagta  tatacaata  tacagcaat  aaataccat  cattccttt  120
tacatcccg  acaagcagc  agttgaaaa  atctttcca  gattgcaag  cctggggcg  180
tctgatgaa  aaatagttt  taaggtagc  gttcttgat  ctgtcccag  atctgtcca  240
aaacaggcc  gaggatggg  agccaagac  gaggacagg  tgggagggg  catagcttc  300
cttccaccg  ggc  313



<210> 61
<211> 294
<212> PRT
<213> Homo sapiens
<308> CAB45239
<400> 61

Met Ala Gly Thr Tyr Ser Ser Thr Leu Lys Thr Leu Glu Asp Leu Thr 
  1               5                  10                  15
Leu Asp Ser Gly Tyr Gly Ala Gly Asp Ser Cys Arg Ser Leu Ser Leu 
             20                  25                  30
Ser Ser Ser Lys Ser Asn Ser Gln Ala Leu Asn Ser Ser Ala Gln Gln 
         35                  40                  45
His Arg Gly Ala Ala Trp Trp Cys Tyr Ser Gly Ser Met Asn Ser Arg 
     50                  55                  60
His Asn Ser Trp Asp Thr Val Asn Thr Val Leu Pro Glu Asp Pro Glu 
 65                  70                  75                  80
Val Ala Asp Leu Phe Ser Arg Cys Pro Arg Leu Pro Glu Leu Glu Glu 
                 85                  90                  95
Phe Pro Trp Thr Glu Gly Asp Val Ala Arg Val Leu Arg Lys Gly Ala 
             100                105                110
Gly Gly Arg Arg Leu Pro Gln Phe Ser Ala Glu Ala Val Arg Arg Leu 
         115                120                125
Ala Gly Leu Leu Arg Arg Ala Leu Ile Arg Val Ala Arg Glu Ala Gln 
     130                135                140
Arg Leu Ser Val Leu His Ala Lys Cys Thr Arg Phe Glu Val Gln Ser 
 145                150                155                160
Ala Val Arg Leu Val His Ser Trp Ala Leu Ala Glu Ser Cys Ala Leu 
                 165                170                175
Ala Ala Val Lys Ala Leu Ser Leu Tyr Ser Met Ser Ala Gly Asp Gly 
             180                185                190
Leu Arg Arg Gly Lys Ser Ala Arg Cys Gly Leu Thr Phe Ser Val Gly 
         195                200                205
Arg Phe Phe Arg Trp Met Val Asp Thr Arg Ile Ser Val Arg Ile His 
     210                215                220
Glu Tyr Ala Ala Ile Ser Leu Thr Ala Cys Met Glu Asn Leu Val Glu 
 225                230                235                240
Glu Ile Arg Ala Arg Val Met Ala Ser His Ser Pro Asp Gly Gly Gly 
                 245                250                255
Ala Gly Gly Gly Glu Val Ser Ala Glu Ala Leu Glu Met Val Ile Asn 
             260                265                270
Asn Asp Ala Glu Leu Trp Gly Val Leu Gln Pro Tyr Glu His Leu Ile 
         275                280                285
Cys Gly Lys Asn Ala Asn 
     290



<210> 62
<211> 2138
<212> DNA
<213> Rattus norvegicus
<308> AB000929
<400> 62

cctggaggt  tcttccaac  tggctaggt  gcagagagt  tactggttg  gttctctct  60
cttcgccct  gtgacttca  taaattcat  aagccttcc  cagtcagag  atcctgcct  120
cccaggcac  ctcatttgt  ataaagatg  agtgagagt  gaattttca  gcagatttg  180
catggaaaa  tggaatcct  ccttggtgg  tacctttgg  aatgaaatt  cgaactgca  240
ttatgctct  gacttggaa  agtttatcc  gaaattccc  tacgagacc  gtactataa  300
agtgattgg  ggataccag  tgaacatca  agtgcagga  accaatgct  atgtaagct  360
taaagatga  gtgcatcac  ttttctgcc  agctattca  gcagagatt  atgaggtct  420
agaaattgt  gtctgcatg  aggatctca  atctttttc  ttcccacaa  ttttctcta  480
gcttgctga  gaaaatcag  atgtatctg  gatgggatg  attattaag  ttggcaatg  540
tacaagagt  cacactctg  ccctgaagg  tgctatagt  caaggattt  atctcctga  600
tgacagcca  aaaataacc  tccatgtgc  agccaatgc  accggagta  ctcactatg  660
gcaagagag  agctatctc  atactgtac  gctgaagct  ttgttctca  gtcctgggc  720
gaagatcac  ttctcttca  aagctatct  tgcaccaga  ctttctgtg  cttgtaatg  780
gacacacat  agtcttact  taccagaat  tcctgggaa  ctaaaatct  tgggctttg  840
acaaaggaa  atccctgag  atcaatggc  tgccaatgg  attgacaaa  aagcaacaa  900
tggcttgag  ctgcatttc  gaaaatctc  cttgaagac  aaaccctct  aaaagtgtc  960
attctacca  ttctacttc  cttcactcg  gctgacctt  aacttccaa  gggacatgc  1020
atccacagt  attgatccc  agtgccact  tgagtcacc  gtctccata  atgaactgt  1080
tacacggga  gggtttatg  actttgagg  ctacagcca  caaacaaaa  ctgcactaa  1140
cctggagag  ctcctggtg  gaaactcct  ctgccagcc  attttcaag  ttcagtctc  1200
ggggcttgc  agatttcac  tacctctga  tggatgtgg  acacgacag  aatttgaag  1260
tgataaagt  atctatgag  atgaaatcc  tgctctctg  gaaaatcca  cgtcaaaca  1320
tattttcag  aacagtgag  tcaggatga  cgtgagatg  cattacatc  gagacagta  1380
gctactaag  gcccatatc  aaagccatt  ttctccagt  gcctctgta  agccaggtc  1440
actagcgtt  gtcctacaa  cctacccag  catatccta  caacggcct  ataggaaga  1500
tgagtaccc  ctagtgagg  acctccgcc  gcccatcta  atggaagtg  cagtcttga  1560
tagaaatga  cccaacatc  agctggttt  agatgactg  tgggcaaca  cttttgagg  1620
cccagcctc  gtcccccag  ggcagatca  tatggatgg  tgtgaatat  aactggaca  1680
ttaccgcac  actttccac  cagccaact  ctctgcagc  cattctggt  actaccaga  1740
gtttgatgt  aagactttt  cctttgtgt  agagtctcg  gggctctcc  gcctgatct  1800
cttccactg  agtgccttg  tctgtaacc  agcctcccc  ctgtgctct  tgacttgcc  1860
tgcaccact  aggaacaaa  gagaggcca  caaagaagg  acaatgacg  ttagcctcc  1920
aggacctat  atcttgttg  cagatgact  ttcatccaa  ggtgtaatg  accctgaca  1980
ctatgagat  accaaagat  ttgcttcta  aacattggg  gctgtggct  cactagtgg  2040
ctcagcagt  atcataggt  tcatctgtt  cctgcataa  aaaagaatt  taaggttca  2100
ttcctgatt  gacttttgc  aataaaaga  gctgcagt  2138



<210> 63
<211> 695
<212> PRT
<213> Rattus norvegicus
<308> BAA24487
<400> 63

Met Ala Arg Trp Gln Arg Val Tyr Trp Leu Arg Ser Leu Phe Phe Ala 
  1               5                  10                  15
Leu Val Thr Ser Val Asn Ser Leu Ser Leu Pro Gln Ser Glu Asn Pro 
             20                  25                  30
Ala Phe Pro Gly Thr Leu Ile Cys Asp Lys Asp Glu Val Arg Val Glu 
         35                  40                  45
Phe Ser Ser Arg Phe Asp Met Glu Lys Trp Asn Pro Ser Leu Val Asp 
     50                  55                  60
Thr Phe Gly Asn Glu Ile Ser Asn Cys Thr Tyr Ala Leu Asp Leu Glu 
 65                  70                  75                  80
Lys Phe Ile Leu Lys Phe Pro Tyr Glu Thr Cys Thr Ile Lys Val Ile 
                 85                  90                  95
Gly Gly Tyr Gln Val Asn Ile Arg Val Gln Asp Thr Asn Ala Asp Val 
             100                105                110
Ser Tyr Lys Asp Asp Val His His Phe Phe Cys Pro Ala Ile Gln Ala 
         115                120                125
Glu Ile His Glu Val Ser Glu Ile Val Val Cys Met Glu Asp Leu Ile 
     130                135                140
Ser Phe Ser Phe Pro Gln Leu Phe Ser Arg Leu Ala Asp Glu Asn Gln 
 145                150                155                160
Asn Val Ser Glu Met Gly Trp Ile Ile Lys Ile Gly Asn Gly Thr Arg 
                 165                170                175
Val His Thr Leu Pro Leu Lys Asp Ala Ile Val Gln Gly Phe Asn Leu 
             180                185                190
Leu Ile Asp Ser Gln Lys Ile Thr Leu His Val Pro Ala Asn Ala Thr 
         195                200                205
Gly Val Ala His Tyr Val Gln Glu Ser Ser Tyr Leu Tyr Thr Val Gln 
     210                215                220
Leu Lys Leu Leu Phe Ser Ser Pro Gly Gln Lys Ile Thr Phe Ser Ser 
 225                230                235                240
Gln Ala Ile Cys Ala Pro Asp Leu Ser Val Ala Cys Asn Val Thr His 
                 245                250                255
Met Ser Leu Thr Ile Pro Glu Phe Pro Gly Lys Leu Lys Ser Val Gly 
             260                265                270
Phe Gly Gln Arg Asn Ile Pro Glu Asp Gln Trp His Ala Asn Gly Ile 
         275                280                285
Asp Lys Glu Ala Thr Asn Gly Leu Arg Leu His Phe Arg Lys Ser Leu 
     290                295                300
Leu Lys Thr Lys Pro Ser Glu Lys Cys Pro Phe Tyr Gln Phe Tyr Phe 
 305                310                315                320
Ser Ser Leu Glu Leu Thr Phe Asn Phe Gln Gly Asp Met Leu Ser Thr 
                 325                330                335
Val Ile Asp Pro Glu Cys His Cys Glu Ser Pro Val Ser Ile Asp Glu 
             340                345                350
Leu Cys Thr Arg Asp Gly Phe Met Asp Phe Glu Val Tyr Ser His Gln 
         355                360                365
Thr Lys Pro Ala Leu Asn Leu Glu Ser Leu Leu Val Gly Asn Ser Ser 
     370                375                380
Cys Gln Pro Ile Phe Lys Val Gln Ser Leu Gly Leu Ala Arg Phe His 
 385                390                395                400
Ile Pro Leu Asn Gly Cys Gly Thr Arg Gln Lys Phe Glu Gly Asp Lys 
                 405                410                415
Val Ile Tyr Glu Asn Glu Ile His Ala Leu Trp Glu Asn Pro Pro Ser 
             420                425                430
Asn Ile Ile Phe Arg Asn Ser Glu Phe Arg Met Thr Val Arg Cys His 
         435                440                445
Tyr Ile Arg Asp Ser Met Leu Leu Arg Ala His Ile Lys Ser His Ser 
     450                455                460
Ser Pro Val Ala Ser Val Lys Pro Gly Pro Leu Ala Leu Val Leu Gln 
 465                470                475                480
Thr Tyr Pro Asp Ile Ser Tyr Gln Arg Pro Tyr Arg Lys Asn Glu Tyr 
                 485                490                495
Pro Leu Val Arg Tyr Leu Arg Gln Pro Ile Tyr Met Glu Val Thr Val 
             500                505                510
Leu Asn Arg Asn Asp Pro Asn Ile Lys Leu Val Leu Asp Asp Cys Trp 
         515                520                525
Ala Thr Thr Phe Glu Asp Pro Ala Ser Val Pro Gln Trp Gln Ile Ile 
     530                535                540
Met Asp Gly Cys Glu Tyr Glu Leu Asp Asn Tyr Arg Thr Thr Phe His 
 545                550                555                560
Ala Ala Asn Ser Ser Ala Ala His Ser Gly His Tyr Gln Arg Phe Asp 
                 565                570                575
Val Lys Thr Phe Ala Phe Val Ser Glu Ser Arg Gly Leu Ser Ser Leu 
             580                585                590
Ile Tyr Phe His Cys Ser Ala Leu Ile Cys Asn Gln Ala Ser Pro Leu 
         595                600                605
Cys Ser Val Thr Cys Pro Ala Pro Leu Arg Asn Lys Arg Glu Ala Ser 
     610                615                620
Lys Glu Gly Thr Met Thr Val Ser Leu Pro Gly Pro Ile Ile Leu Leu 
 625                630                635                640
Ser Asp Asp Ser Ser Ser Lys Gly Val Met Asn Pro Asp Ser Tyr Glu 
                 645                650                655
Ile Thr Lys Asp Ile Ala Ser Lys Thr Leu Gly Ala Val Ala Ala Leu 
             660                665                670
Val Gly Ser Ala Val Ile Ile Gly Phe Ile Cys Tyr Leu His Lys Lys 
         675                680                685
Arg Ile Val Arg Phe Asn Ser 
     690                695



<210> 64
<211> 2266
<212> DNA
<213> Homo sapiens
<308> M90366
<400> 64

atggcgtgc  ggcagagag  aggctcttg  agtccctca  gctggttca  tgcaggctg  60
agcacctac  ggtcgattt  tctcttctt  gcccttgtg  cttcaggga  ctccataga  120
gtttctcag  tggtaaatc  tgcctttcc  ggcactgtc  cttgcgatg  aagggaaat  180
acagtggag  tcccaagca  tcctggcac  aagaaatgg  atgcatctg  ggtggatcc  240
cttggtctc  acatgccga  ctgcactta  atcctggac  cagaaaagc  caccctgag  300
gctacctat  ataactgta  caggagagt  catggtgga  accagatga  catcagagt  360
atgaacaac  gtgctgcct  aagacacgg  gctgtcatg  atcagttct  ctgtccagc  420
atgcaagta  aagagaccc  ggggctttc  gcatctaca  tctgccaga  ggatttcat  480
tctttttcc  tgccacggg  cttctctgg  ttggctgac  acagtaagg  gaccaaagt  540
cagatggga  ggagcattg  ggttggtga  ggtgcaaga  ccaaaactc  gaccctgcc  600
gaggccatg  aggaaggct  cagcctctt  attgacaac  acaggatga  cttccatgt  660
ccattcaat  ccactggag  gactcacta  gtgcaaggt  acagtcatc  ctacatggt  720
tctctgaag  ttacattta  atctcctgg  cagaaggtg  tcttctctt  acaagctat  780
tgtgcacca  atcctgtga  ctgcaatgc  acacacatg  ctctcacca  accagagtt  840
cctgggaag  ttaagtctg  gagctttga  aaccagaac  ttgatgtga  ccagctgca  900
gacaatgga  ttgatctag  agcaacaaa  ggcatgaaa  tgcatttca  caaaactct  960
ctcaaaacg  aattatctg  aaaatgcct  ctccatcag  tctacttag  ttcactcaa  1020
ctgaccttt  tccttcggc  agagacagt  tccatggtg  tctatcctg  gtgtctctg  1080
gagtcaccc  tttctatag  tacagggga  ctgtgcacc  aggatgggt  tatggacgt  1140
gaggtctac  gctaccaaa  acaaccagc  cttgacctg  gtactctga  ggtgggaaa  1200
tcatcctgc  agcctgtct  tgaggctca  tctcagggg  tggtacggt  ccacatacc  1260
ctgaatgga  gtggaacga  atataagtt  gaagatgat  aagtcgtct  tgaaaacga  1320
atacatgct  tctggacgg  ttttcctcc  agcaaaata  ctagagaca  tgagttcag  1380
atgacagtg  agtgttctt  tagcaggaa  gacatgcta  taaacatca  cgttgaaag  1440
cttactcct  cagtggcct  agtgaagtt  ggtccattt  ccttgatcc  gcaaagcta  1500
ccagataat  cctaccaac  accttatgg  gaaaacgag  accctctag  gagattcct  1560
cgccaacca  tttacatgg  agtgagagt  ctaaacagg  atgacccca  catcaagct  1620
gtcttagat  actgctggg  gacgtccac  atggatcca  actctttcc  ccagtggaa  1680
gttgtcgtg  atggctgtg  atatgacct  gacaactac  agaccacct  ccatccagt  1740
ggctcctct  tgacccatc  tgatcacta  cagaggttt  acatgaagg  ttttgcctt  1800
gtatcagaa  cccacgtgc  ctctagcct  gtctacttc  actgcagtg  cttaatctg  1860
aatcgactc  cccctgact  cccactgtg  tctgtgacc  gccctgtgt  ctctaggca  1920
aggcgagcc  caggggcca  tgaagcaga  aaaatgaca  tcagcctcc  aggacccat  1980
ctcctgttg  cagatgact  ctcattcag  ggtgtcggc  catctgatc  aaaagcaag  2040
gggagcagt  gggagaaga  taggagtga  acaggggag  aggttggct  acgaggtgc  2100
atggacacc  aagggcaca  gactgctgg  gatgttggt  ccaaagctg  ggctgctgt  2160
gctgccttt  caggtgtgg  ggcaactct  ggcttcatc  actacctgt  cgagaaaag  2220
actgtgtca  atcactaaa  gggcttcta  ataaagcag  caaaat  2266



<210> 65
<211> 745
<212> PRT
<213> Homo sapiens
<308> Q05996
<400> 65

Met Ala Cys Arg Gln Arg Gly Gly Ser Trp Ser Pro Ser Gly Trp Phe 
  1               5                  10                  15
Asn Ala Gly Trp Ser Thr Tyr Arg Ser Ile Ser Leu Phe Phe Ala Leu 
             20                  25                  30
Val Thr Ser Gly Asn Ser Ile Asp Val Ser Gln Leu Val Asn Pro Ala 
         35                  40                  45
Phe Pro Gly Thr Val Thr Cys Asp Glu Arg Glu Ile Thr Val Glu Phe 
     50                  55                  60
Pro Ser Ser Pro Gly Thr Lys Lys Trp His Ala Ser Val Val Asp Pro 
 65                  70                  75                  80
Leu Gly Leu Asp Met Pro Asn Cys Thr Tyr Ile Leu Asp Pro Glu Lys 
                 85                  90                  95
Leu Thr Leu Arg Ala Thr Tyr Asp Asn Cys Thr Arg Arg Val His Gly 
             100                105                110
Gly His Gln Met Thr Ile Arg Val Met Asn Asn Ser Ala Ala Leu Arg 
         115                120                125
His Gly Ala Val Met Tyr Gln Phe Phe Cys Pro Ala Met Gln Val Glu 
     130                135                140
Glu Thr Gln Gly Leu Ser Ala Ser Thr Ile Cys Gln Lys Asp Phe Met 
 145                150                155                160
Ser Phe Ser Leu Pro Arg Val Phe Ser Gly Leu Ala Asp Asp Ser Lys 
                 165                170                175
Gly Thr Lys Val Gln Met Gly Trp Ser Ile Glu Val Gly Asp Gly Ala 
             180                185                190
Arg Ala Lys Thr Leu Thr Leu Pro Glu Ala Met Lys Glu Gly Phe Ser 
         195                200                205
Leu Leu Ile Asp Asn His Arg Met Thr Phe His Val Pro Phe Asn Ala 
     210                215                220
Thr Gly Val Thr His Tyr Val Gln Gly Asn Ser His Leu Tyr Met Val 
 225                230                235                240
Ser Leu Lys Leu Thr Phe Ile Ser Pro Gly Gln Lys Val Ile Phe Ser 
                 245                250                255
Ser Gln Ala Ile Cys Ala Pro Asp Pro Val Thr Cys Asn Ala Thr His 
             260                265                270
Met Thr Leu Thr Ile Pro Glu Phe Pro Gly Lys Leu Lys Ser Val Ser 
         275                280                285
Phe Glu Asn Gln Asn Ile Asp Val Ser Gln Leu His Asp Asn Gly Ile 
     290                295                300
Asp Leu Glu Ala Thr Asn Gly Met Lys Leu His Phe Ser Lys Thr Leu 
 305                310                315                320
Leu Lys Thr Lys Leu Ser Glu Lys Cys Leu Leu His Gln Phe Tyr Leu 
                 325                330                335
Ala Ser Leu Lys Leu Thr Phe Leu Leu Arg Pro Glu Thr Val Ser Met 
             340                345                350
Val Ile Tyr Pro Glu Cys Leu Cys Glu Ser Pro Val Ser Ile Val Thr 
         355                360                365
Gly Glu Leu Cys Thr Gln Asp Gly Phe Met Asp Val Glu Val Tyr Ser 
     370                375                380
Tyr Gln Thr Gln Pro Ala Leu Asp Leu Gly Thr Leu Arg Val Gly Asn 
 385                390                395                400
Ser Ser Cys Gln Pro Val Phe Glu Ala Gln Ser Gln Gly Leu Val Arg 
                 405                410                415
Phe His Ile Pro Leu Asn Gly Cys Gly Thr Arg Tyr Lys Phe Glu Asp 
             420                425                430
Asp Lys Val Val Tyr Glu Asn Glu Ile His Ala Leu Trp Thr Asp Phe 
         435                440                445
Pro Pro Ser Lys Ile Ser Arg Asp Ser Glu Phe Arg Met Thr Val Lys 
     450                455                460
Cys Ser Tyr Ser Arg Asn Asp Met Leu Leu Asn Ile Asn Val Glu Ser 
 465                470                475                480
Leu Thr Pro Pro Val Ala Ser Val Lys Leu Gly Pro Phe Thr Leu Ile 
                 485                490                495
Leu Gln Ser Tyr Pro Asp Asn Ser Tyr Gln Gln Pro Tyr Gly Glu Asn 
             500                505                510
Glu Tyr Pro Leu Val Arg Phe Leu Arg Gln Pro Ile Tyr Met Glu Val 
         515                520                525
Arg Val Leu Asn Arg Asp Asp Pro Asn Ile Lys Leu Val Leu Asp Asp 
     530                535                540
Cys Trp Ala Thr Ser Thr Met Asp Pro Asp Ser Phe Pro Gln Trp Asn 
 545                550                555                560
Val Val Val Asp Gly Cys Ala Tyr Asp Leu Asp Asn Tyr Gln Thr Thr 
                 565                570                575
Phe His Pro Val Gly Ser Ser Val Thr His Pro Asp His Tyr Gln Arg 
             580                585                590
Phe Asp Met Lys Ala Phe Ala Phe Val Ser Glu Ala His Val Leu Ser 
         595                600                605
Ser Leu Val Tyr Phe His Cys Ser Ala Leu Ile Cys Asn Arg Leu Ser 
     610                615                620
Pro Asp Ser Pro Leu Cys Ser Val Thr Cys Pro Val Ser Ser Arg His 
 625                630                635                640
Arg Arg Ala Thr Gly Ala Thr Glu Ala Glu Lys Met Thr Val Ser Leu 
                 645                650                655
Pro Gly Pro Ile Leu Leu Leu Ser Asp Asp Ser Ser Phe Arg Gly Val 
             660                665                670
Gly Ser Ser Asp Leu Lys Ala Ser Gly Ser Ser Gly Glu Lys Ser Arg 
         675                680                685
Ser Glu Thr Gly Glu Glu Val Gly Ser Arg Gly Ala Met Asp Thr Lys 
     690                695                700
Gly His Lys Thr Ala Gly Asp Val Gly Ser Lys Ala Val Ala Ala Val 
 705                710                715                720
Ala Ala Phe Ala Gly Val Val Ala Thr Leu Gly Phe Ile Tyr Tyr Leu 
                 725                730                735
Tyr Glu Lys Arg Thr Val Ser Asn His 
             740                745



<210> 66
<211> 2347
<212> DNA
<213> Rattus norvegicus
<308> AB002111
<400> 66

ggagcttct  tttccgggt  cggtttctg  cacaaagcc  agccctcct  tcgcaggtg  60
cgtcacggg  cctctgctc  gtgcccgag  tcagcaagc  aggacgggc  cttcccagc  120
agccaccgg  gccgggcct  gcagctctg  gactgcagc  cgagcgaca  gttccttgg  180
ccacaccta  ctccgagtc  cgctctgcc  tgtgaggtg  catgcagaa  gactaagac  240
cagcacccg  ttgatacaa  acaagttca  gctccctag  gtgttcgtg  gaaaagtaa  300
tcccagtac  cacaagaca  tatggctga  catggggct  atatcacaa  tgcttcggt  360
gcggacgac  agccatcca  ctttgaggt  gtagcacag  acagtttaa  gacagcagt  420
agacccgct  ttcagcatg  ggtcaaggt  cttgcagaa  caaatcctg  gcactatgg  480
ttcttttgg  ggtggtttg  tgaaatctt  actctgcta  actttctgc  ccagcagca  540
tatctttct  gaactagtg  ctcattttc  gaacacttt  atgggttaa  gcggattgt  600
gcggggagc  cgccgcagc  tcagagacc  gccagtgct  gcctcccca  ggaacacct  660
tggaaatcc  ctatgttcc  tgttcttct  ccctatctg  aagtgaagc  ggagaagct  720
gcttctacc  tgagagaag  agacgaata  tctattcac  ccccttctt  tcactggaa  780
cgattctac  gagtcttcc  ggctgccta  ccgtttgtt  ccatgacct  ggaaggctg  840
ttccttaca  aacaacttc  gtacatatt  ggaaaagct  agcatcact  tcccctgct  900
aaactggct  gagttcggc  aggtcgact  acagctcag  acatacaag  tatggaaca  960
agactggtt  aagccagtg  aatgcagga  cccgtcaga  gcattggta  gaagataaa  1020
tcagcactg  agaaagctg  gggaggtgt  gccttatcc  tctctactg  cctctctgt  1080
ggtgtattc  tcctgcagt  tcttgactg  tggtactct  ctgagaacc  agagaccat  1140
aagtcactg  ctgccctgc  cactccacc  ccacctgtg  acctcgact  caactctga  1200
tctcccctc  tacccaaaa  gaaaacagt  tgcccactg  gtcgtaaag  tcgggtcaa  1260
gatacggtt  ttgccacct  tggctatgt  ttctgttac  gctgtgtgt  taattatgt  1320
agaagtcac  aagcctgtc  cattacagg  tatccaacg  aagtccagc  tctaattaa  1380
ctctactct  cagagaact  aaagagaga  tagtgtatt  tctcacagc  caagttcta  1440
actatagga  cacaagatg  ttttagtat  gcaatcaac  atgattcat  actacatta  1500
cttttagta  ttatatgga  ttctttaaa  ggatatatc  acttggtcc  aaccttatg  1560
tttgctctc  accaagctg  ttaagcagg  gaatcagga  tgtaggtgg  gtgagggcc  1620
atgtggagg  gggttataa  agaccacct  acttaagag  aaggtttta  gttgtggta  1680
tgtagtgtc  gcactctgg  gatggaggc  ggagtttga  ttcaaggcc  ccaaagggg  1740
agtgtcaaa  gtaaaatga  agtaagaga  tgattaaga  ggataaaat  gcataggaa  1800
ccccaggtt  gatcttaca  agcaagtgg  ttgggaagc  ggccttctc  ttagaaaac  1860
tttctctac  tttgaagta  aggctttat  agacacgga  tttctcttt  tagaaatat  1920
tataaaccc  ttagagaaa  gccccctcc  tctatcatg  cttactaac  tctaccaca  1980
tttatcagt  tttgaagat  tccttcatg  tccatacct  cctgtctag  gaagggttt  2040
tttatgggg  ggagtctgg  aatttcaat  tgaataaaa  ctagcaatg  tgagatgca  2100
taaaatctt  atctaatgt  tacctgatg  ctacctaat  gatatctaa  gagtaaaag  2160
tttctgctt  ctcttatga  tttgctcag  tgataggaa  catgctagg  attatgaaa  2220
tttctatga  acatttaat  aaattttaa  aatacatga  tctaggaaa  aattgttcc  2280
tgctgtcat  attatgtgg  aactcaaaa  atcacttca  gagtttaaa  aaattttta  2340
tcagatc  2347



<210> 67
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> O88177
<400> 67

Met Ala Glu His Gly Ala His Ile Thr Thr Ala Ser Val Ala Asp Asp 
  1               5                  10                  15
Gln Pro Ser Ile Phe Glu Val Val Ala Gln Asp Ser Leu Met Thr Ala 
             20                  25                  30
Val Arg Pro Ala Leu Gln His Val Val Lys Val Leu Ala Glu Ser Asn 
         35                  40                  45
Pro Ala His Tyr Gly Phe Phe Trp Arg Trp Phe Asp Glu Ile Phe Thr 
     50                  55                  60
Leu Leu Asp Phe Leu Leu Gln Gln His Tyr Leu Ser Arg Thr Ser Ala 
 65                  70                  75                  80
Ser Phe Ser Glu His Phe Tyr Gly Leu Lys Arg Ile Val Ala Gly Ser 
                 85                  90                  95
Ser Pro Gln Leu Gln Arg Pro Ala Ser Ala Gly Leu Pro Lys Glu His 
             100                105                110
Leu Trp Lys Ser Ala Met Phe Leu Val Leu Leu Pro Tyr Leu Lys Val 
         115                120                125
Lys Leu Glu Lys Leu Ala Ser Thr Leu Arg Glu Glu Asp Glu Tyr Ser 
     130                135                140
Ile His Pro Pro Ser Ser His Trp Lys Arg Phe Tyr Arg Val Phe Leu 
 145                150                155                160
Ala Ala Tyr Pro Phe Val Thr Met Thr Trp Glu Gly Trp Phe Leu Thr 
                 165                170                175
Gln Gln Leu Arg Tyr Ile Leu Gly Lys Ala Glu His His Ser Pro Leu 
             180                185                190
Leu Lys Leu Ala Gly Val Arg Leu Gly Arg Leu Thr Ala Gln Asp Ile 
         195                200                205
Gln Ala Met Glu His Arg Leu Val Glu Ala Ser Ala Met Gln Glu Pro 
     210                215                220
Val Arg Ser Ile Gly Lys Lys Ile Lys Ser Ala Leu Lys Lys Ala Val 
 225                230                235                240
Gly Gly Val Ala Leu Ser Leu Ser Thr Gly Leu Ser Val Gly Val Phe 
                 245                250                255
Phe Leu Gln Phe Leu Asp Trp Trp Tyr Ser Ser Glu Asn Gln Glu Thr 
             260                265                270
Ile Lys Ser Leu Thr Ala Leu Pro Thr Pro Pro Pro Pro Val His Leu 
         275                280                285
Asp Tyr Asn Ser Asp Ser Pro Leu Leu Pro Lys Met Lys Thr Val Cys 
     290                295                300
Pro Leu Cys Arg Lys Ala Arg Val Asn Asp Thr Val Leu Ala Thr Ser 
 305                310                315                320
Gly Tyr Val Phe Cys Tyr Arg Cys Val Phe Asn Tyr Val Arg Ser His 
                 325                330                335
Gln Ala Cys Pro Ile Thr Gly Tyr Pro Thr Glu Val Gln His Leu Ile 
             340                345                350
Lys Leu Tyr Ser Pro Glu Asn 
         355



<210> 68
<211> 2609
<212> DNA
<213> Homo sapiens
<308> U91521
<400> 68

cgcccgggc  ggtctccct  caaacgtgg  gtcgtgggt  gtttgcgcc  cgcctgggg  60
cagcgagca  ggacgggcg  gggcgggga  actcaaagc  aacagctgg  gtcagccct  120
gtgtcccgg  ctcacagtg  cacgactga  tcctcagag  cggctggct  ttgagctct  180
acgattggg  aggaggggg  gtttctggt  cgcagctcc  gaggattgc  ttccttccc  240
catacctgt  ccccacagt  acgctctgc  ctgacgtgc  gcatttgac  agttacccc  300
tcgccacat  ctacttcca  ccacgtccg  gttaacttt  ttcttaacc  tcttgagac  360
accctcggc  tccaggtct  tttttccca  ttcattttt  cccataaga  tgagtttcg  420
gtttcagat  tcatgcaga  agtttacct  taagactga  cacccatct  atactcttc  480
tcccgaaaa  gttcatgct  acgagagag  ttgtgggaa  agtgaaagc  agtacacgc  540
ggaaactat  gctgagcac  gggctcact  cacagctgc  tctgtggcc  atgaccagc  600
atccatctt  gaggtggta  cacaggaca  tttaatgac  gcagtgaga  ccgctcttc  660
gcatgtggt  aaggttctt  cagaatcaa  tcccaccca  tatggcttc  tgtggaggt  720
gtttgatga  atctttact  tgctagatc  tctgctcca  caacattat  tgtctagaa  780
cagtgcctc  ttttctgaa  acttttacg  cttaaagag  attgtaatg  gggacactc  840
caagtctca  agattggct  gtgctggtc  cccaaagca  cagctttgg  aatctatta  900
gttcctggt  cttcttccc  atctgaaag  gaagctgga  aagctggtt  ctagcctga  960
agaagagga  gaatattct  ttcatcccc  ttcttcccg  tggaaacga  tttacagag  1020
tttcctggc  gcctaccca  ttgtgaaca  ggcctggga  ggatggttt  ttgtacaac  1080
acttcgata  atcctagga  aagctcagc  tcactcacc  ctgctgagg  tggctggag  1140
tcagctagg  cgactgaca  ttcaggata  acaagctct  gagcacaaa  cagctaagg  1200
cagcatgat  cagcaacca  ccaggagtg  tagtgagaa  ataaactca  ctctgaaga  1260
agctgttgg  ggtgttgcc  tatccctgt  tactggcct  tctgtgggt  tattcttct  1320
gcagttcct  gactggtgg  actcatctg  aaatcaaga  accatcaag  cattgactg  1380
cctgcctac  ccaccacca  ctgtacacc  agactataa  tctgattct  ccctcttac  1440
caaaatgaa  actgtgtgc  cactgtgtc  taaaacccg  gtgaatgat  ctgttcttg  1500
cacctctgg  tatgtgttt  gttaccgct  tgtgtttca  tatgtgagg  gtcaccaag  1560
ttgtcccat  acaggttat  caacagaag  acaacatct  attaaactc  actcccctg  1620
gaactgaaa  ggaatcatg  cttatcctc  caacaaaag  attgcgctg  aatgtcaca  1680
agctggttt  agcatggta  tgagttgac  cttctcagc  tcaattcat  actatatga  1740
ctttaaatg  ttatatgga  ttctttaaa  ggatatgcc  atttgatcc  aacctttta  1800
cctgctctc  agaacccta  ttacagttg  ccaagctgc  taaagtaga  ggatcagga  1860
tggcagggg  tatgagggc  agtgtagag  ttaaacaga  taatgagta  acaagtttt  1920
gcctatccc  ttccttaaa  tataagaaa  aaaggagct  ttacgaaaa  cccaggtta  1980
accgcataa  aaataaagt  aacagtgag  tggtagcaa  acttctttt  agaaaagaa  2040
gcatttacc  gcctgtctg  aaggtggaa  tttcatcag  ttgcaaacg  taagaaatg  2100
agacttgct  ttgatagaa  tgcttagaa  cactctggg  gggaaaaaa  ctccttcca  2160
atactgtga  acatttgtt  agtgacatc  attgtttat  agcttttaa  gataaaaaa  2220
gtattttaa  agttggata  ttaggatat  tgaggatat  cctttatga  ctctccata  2280
ccttcttga  aaactggtt  aaaaaggaa  aggggtaga  tgttacaga  agtagtctg  2340
agattcctg  gtaaaagca  agctaacaa  caatgaaga  atgaagcaa  atactaatc  2400
aattgtgta  agaaaggat  ttttaataa  ttctttctg  ttgctgcta  gagtttgct  2460
aagtgtcat  aattattct  gttattact  aagtttcta  gaaacaagt  gattttaag  2520
ataaatgtt  ctggaaaag  actatgtta  gattttgta  aaatgtaaa  attacttga  2580
gtgtttaaa  taaattttt  attcagact  2609



<210> 69
<211> 359
<212> PRT
<213> Homo sapiens
<308> O00623
<400> 69

Met Ala Glu His Gly Ala His Phe Thr Ala Ala Ser Val Ala Asp Asp 
  1               5                  10                  15
Gln Pro Ser Ile Phe Glu Val Val Ala Gln Asp Ser Leu Met Thr Ala 
             20                  25                  30
Val Arg Pro Ala Leu Gln His Val Val Lys Val Leu Ala Glu Ser Asn 
         35                  40                  45
Pro Thr His Tyr Gly Phe Leu Trp Arg Trp Phe Asp Glu Ile Phe Thr 
     50                  55                  60
Leu Leu Asp Leu Leu Leu Gln Gln His Tyr Leu Ser Arg Thr Ser Ala 
 65                  70                  75                  80
Ser Phe Ser Glu Asn Phe Tyr Gly Leu Lys Arg Ile Val Met Gly Asp 
                 85                  90                  95
Thr His Lys Ser Gln Arg Leu Ala Ser Ala Gly Leu Pro Lys Gln Gln 
             100                105                110
Leu Trp Lys Ser Ile Met Phe Leu Val Leu Leu Pro Tyr Leu Lys Val 
         115                120                125
Lys Leu Glu Lys Leu Val Ser Ser Leu Arg Glu Glu Asp Glu Tyr Ser 
     130                135                140
Ile His Pro Pro Ser Ser Arg Trp Lys Arg Phe Tyr Arg Ala Phe Leu 
 145                150                155                160
Ala Ala Tyr Pro Phe Val Asn Met Ala Trp Glu Gly Trp Phe Leu Val 
                 165                170                175
Gln Gln Leu Arg Tyr Ile Leu Gly Lys Ala Gln His His Ser Pro Leu 
             180                185                190
Leu Arg Leu Ala Gly Val Gln Leu Gly Arg Leu Thr Val Gln Asp Ile 
         195                200                205
Gln Ala Leu Glu His Lys Pro Ala Lys Ala Ser Met Met Gln Gln Pro 
     210                215                220
Ala Arg Ser Val Ser Glu Lys Ile Asn Ser Ala Leu Lys Lys Ala Val 
 225                230                235                240
Gly Gly Val Ala Leu Ser Leu Ser Thr Gly Leu Ser Val Gly Val Phe 
                 245                250                255
Phe Leu Gln Phe Leu Asp Trp Trp Tyr Ser Ser Glu Asn Gln Glu Thr 
             260                265                270
Ile Lys Ser Leu Thr Ala Leu Pro Thr Pro Pro Pro Pro Val His Leu 
         275                280                285
Asp Tyr Asn Ser Asp Ser Pro Leu Leu Pro Lys Met Lys Thr Val Cys 
     290                295                300
Pro Leu Cys Arg Lys Thr Arg Val Asn Asp Thr Val Leu Ala Thr Ser 
 305                310                315                320
Gly Tyr Val Phe Cys Tyr Arg Cys Val Phe His Tyr Val Arg Ser His 
                 325                330                335
Gln Ala Cys Pro Ile Thr Gly Tyr Pro Thr Glu Val Gln His Leu Ile 
             340                345                350
Lys Leu Tyr Ser Pro Glu Asn 
         355



<210> 70
<211> 975
<212> DNA
<213> Rattus norvegicus
<308> AB003515
<400> 70

cccgcctgc  gagtagtcg  cgctgccgc  gccgcctcc  ttgttgttg  ggtcgcttc  60
ccgaagtct  cggctcaaa  agccggctc  gtcgcttcc  gccgccatg  agtggatgt  120
taaggagga  cactcgctg  aacacagat  cgtggaatc  gcgaagatc  gagcgaaat  180
ccccgaccg  gttccggtg  tcgttgaga  agtctctgg  tctcagatt  ttgacattg  240
caagaggaa  tacttggtc  catctgaca  cactgtggc  cagttcatg  ggatcatca  300
gaaaaggat  cagcttcct  ctgagaagg  catcttctt  tttgtggac  agacagtcc  360
acagtccag  ctaactatg  gacagcttt  cgagaagga  aaagatgaa  atggattct  420
gtatgtggc  tacagcgga  agaacactt  tggcttctg  gcccttgct  ggctaggtg  480
acccttcct  cttgtgtat  ctgtaaata  ctggctgtt  tcagttact  cgccggagc  540
tccacacag  cctactagt  catttgtaa  tggatttat  tcttaatat  ttggaaggt  600
ttgttttcc  tagattagt  aattatcat  cagagtttt  ttttcagtt  tcttttgtg  660
actgtcctc  tggctatat  ctccaagga  cctgtcctc  ggaatcaca  ttaatgaag  720
tacttccga  atgaagggc  gtaggtgtg  tattaaagt  acaaggagg  atgacgcat  780
gttctggat  atgttcgga  tgttagacg  ctaagtatt  aaagccccc  aattaaatc  840
ttagcaatc  gaacacttg  ttcactaga  tttgccaac  gcaaatcat  ttggactga  900
ctaatctgt  ctttctgag  ctataaggt  aatgattaa  aataaagcc  ccatgtaaa  960
ggcaaaaaa  aaaaa  975



<210> 71
<211> 117
<212> PRT
<213> Rattus norvegicus
<308> O08765
<400> 71

Met Lys Trp Met Phe Lys Glu Asp His Ser Leu Glu His Arg Cys Val 
  1               5                  10                  15
Glu Ser Ala Lys Ile Arg Ala Lys Tyr Pro Asp Arg Val Pro Val Ile 
             20                  25                  30
Val Glu Lys Val Ser Gly Ser Gln Ile Val Asp Ile Asp Lys Arg Lys 
         35                  40                  45
Tyr Leu Val Pro Ser Asp Ile Thr Val Ala Gln Phe Met Trp Ile Ile 
     50                  55                  60
Arg Lys Arg Ile Gln Leu Pro Ser Glu Lys Ala Ile Phe Leu Phe Val 
 65                  70                  75                  80
Asp Lys Thr Val Pro Gln Ser Ser Leu Thr Met Gly Gln Leu Tyr Glu 
                 85                  90                  95
Lys Glu Lys Asp Glu Asp Gly Phe Leu Tyr Val Ala Tyr Ser Gly Glu 
             100                105                110
Asn Thr Phe Gly Phe 
         115



<210> 72
<211> 450
<212> DNA
<213> Homo sapiens
<308> NM_007285
<400> 72

ggctgccgc  gccgctgcc  ccgtcgttg  tgttgtgct  ggtgcgctg  gctccgcgg  60
tccgcgagc  ggttccgtc  ccttcccgc  gccgccatg  agtggatgt  caaggagga  120
cactcgctg  aacacagat  cgtggagtc  gcgaagatt  gagcgaaat  tcccgacag  180
gttccggtg  ttgtggaaa  ggtctcagg  tctcagatt  ttgacattg  caaacggaa  240
tacttggtt  catctgata  cactgtggc  cagttcatg  ggatcatca  gaaaaggat  300
cagcttcct  ctgaaaagg  gatcttcct  tttgtggat  agacagtcc  acagtccag  360
ctaactatg  gacagcttt  cgagaagga  aaagatgaa  atggattct  atatgtggc  420
tacagcgga  agaacactt  tggcttctga  450



<210> 73
<211> 117
<212> PRT
<213> Homo sapiens
<308> O08765
<400> 73

Met Lys Trp Met Phe Lys Glu Asp His Ser Leu Glu His Arg Cys Val 
  1               5                  10                  15
Glu Ser Ala Lys Ile Arg Ala Lys Tyr Pro Asp Arg Val Pro Val Ile 
             20                  25                  30
Val Glu Lys Val Ser Gly Ser Gln Ile Val Asp Ile Asp Lys Arg Lys 
         35                  40                  45
Tyr Leu Val Pro Ser Asp Ile Thr Val Ala Gln Phe Met Trp Ile Ile 
     50                  55                  60
Arg Lys Arg Ile Gln Leu Pro Ser Glu Lys Ala Ile Phe Leu Phe Val 
 65                  70                  75                  80
Asp Lys Thr Val Pro Gln Ser Ser Leu Thr Met Gly Gln Leu Tyr Glu 
                 85                  90                  95
Lys Glu Lys Asp Glu Asp Gly Phe Leu Tyr Val Ala Tyr Ser Gly Glu 
             100                105                110
Asn Thr Phe Gly Phe 
         115



<210> 74
<211> 781
<212> DNA
<213> Rattus norvegicus
<308> AB003991
<400> 74

atggccgag  acgcagaca  gcgtaatga  ctggaggag  tgcagagga  ggctgacca  60
ctggctgat  agtccctgg  aagcacccg  cgcatgctg  agctggtcg  agagagtaa  120
gatgctggc  tcaggactt  ggttatgtt  gatgagcaa  gcgaacaac  cgatcgtgt  180
gaagaaggc  tgaaccata  caaccaaga  atgaaggag  ccgagaaaa  tttaaaaga  240
ttaggcaaa  gctgtggcc  tttcatatg  ccttgtaac  agcttaaat  cagtgatgc  300
tacaaaaaa  cctggggca  taatcagga  ggagtagtg  ccagccagc  tgcccgtgt  360
gtggatgaa  gggagcaga  ggccatcag  ggtggcttc  tccgcaggg  aacaaacga  420
gcccgggaa  atgaaatgg  tgaaaacct  gagcaggtg  gcggcatca  cggaaacct  480
cgtcatatg  ccctagaca  gggcaatga  attgacacc  agaatcgcc  gattgacag  540
atcatggag  aggctgact  caacaaaac  agaattgat  aagccaacc  acgtgcaac  600
aagatgctg  gaagtggtt  aatctgccc  tctgctgtg  tctcctcca  tgttgttgg  660
caagagaga  gagagctcc  tcatgcttc  ctcatggta  tacctagta  gactcacac  720
cacacacac  cacacacac  cacacaggg  tctctcagt  tctgacttc  tttctctcc  780
g  781



<210> 75
<211> 206
<212> PRT
<213> Rattus norvegicus
<308> BAA20151
<400> 75

Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg 
  1               5                  10                  15
Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met 
             20                  25                  30
Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val 
         35                  40                  45
Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met 
     50                  55                  60
Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp 
 65                  70                  75                  80
Leu Gly Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys 
                 85                  90                  95
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val 
             100                105                110
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala 
         115                120                125
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn 
     130                135                140
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu 
 145                150                155                160
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg 
                 165                170                175
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile 
             180                185                190
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly 
         195                200                205



<210> 76
<211> 781
<212> DNA
<213> Rattus norvegicus
<308> AB003991
<400> 76

atggccgag  acgcagaca  gcgtaatga  ctggaggag  tgcagagga  ggctgacca  60
ctggctgat  agtccctgg  aagcacccg  cgcatgctg  agctggtcg  agagagtaa  120
gatgctggc  tcaggactt  ggttatgtt  gatgagcaa  gcgaacaac  cgatcgtgt  180
gaagaaggc  tgaaccata  caaccaaga  atgaaggag  ccgagaaaa  tttaaaaga  240
ttaggcaaa  gctgtggcc  tttcatatg  ccttgtaac  agcttaaat  cagtgatgc  300
tacaaaaaa  cctggggca  taatcagga  ggagtagtg  ccagccagc  tgcccgtgt  360
gtggatgaa  gggagcaga  ggccatcag  ggtggcttc  tccgcaggg  aacaaacga  420
gcccgggaa  atgaaatgg  tgaaaacct  gagcaggtg  gcggcatca  cggaaacct  480
cgtcatatg  ccctagaca  gggcaatga  attgacacc  agaatcgcc  gattgacag  540
atcatggag  aggctgact  caacaaaac  agaattgat  aagccaacc  acgtgcaac  600
aagatgctg  gaagtggtt  aatctgccc  tctgctgtg  tctcctcca  tgttgttgg  660
caagagaga  gagagctcc  tcatgcttc  ctcatggta  tacctagta  gactcacac  720
cacacacac  cacacacac  cacacaggg  tctctcagt  tctgacttc  tttctctcc  780
g  781



<210> 77
<211> 206
<212> PRT
<213> Rattus norvegicus
<308> BAA20151
<400> 77

Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg 
  1               5                  10                  15
Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met 
             20                  25                  30
Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val 
         35                  40                  45
Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met 
     50                  55                  60
Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp 
 65                  70                  75                  80
Leu Gly Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys 
                 85                  90                  95
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val 
             100                105                110
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala 
         115                120                125
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn 
     130                135                140
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu 
 145                150                155                160
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg 
                 165                170                175
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile 
             180                185                190
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly 
         195                200                205



<210> 78
<211> 781
<212> DNA
<213> Rattus norvegicus
<308> AB003991
<400> 78

atggccgag  acgcagaca  gcgtaatga  ctggaggag  tgcagagga  ggctgacca  60
ctggctgat  agtccctgg  aagcacccg  cgcatgctg  agctggtcg  agagagtaa  120
gatgctggc  tcaggactt  ggttatgtt  gatgagcaa  gcgaacaac  cgatcgtgt  180
gaagaaggc  tgaaccata  caaccaaga  atgaaggag  ccgagaaaa  tttaaaaga  240
ttaggcaaa  gctgtggcc  tttcatatg  ccttgtaac  agcttaaat  cagtgatgc  300
tacaaaaaa  cctggggca  taatcagga  ggagtagtg  ccagccagc  tgcccgtgt  360
gtggatgaa  gggagcaga  ggccatcag  ggtggcttc  tccgcaggg  aacaaacga  420
gcccgggaa  atgaaatgg  tgaaaacct  gagcaggtg  gcggcatca  cggaaacct  480
cgtcatatg  ccctagaca  gggcaatga  attgacacc  agaatcgcc  gattgacag  540
atcatggag  aggctgact  caacaaaac  agaattgat  aagccaacc  acgtgcaac  600
aagatgctg  gaagtggtt  aatctgccc  tctgctgtg  tctcctcca  tgttgttgg  660
caagagaga  gagagctcc  tcatgcttc  ctcatggta  tacctagta  gactcacac  720
cacacacac  cacacacac  cacacaggg  tctctcagt  tctgacttc  tttctctcc  780
g  781



<210> 79
<211> 206
<212> PRT
<213> Rattus norvegicus
<308> BAA20151
<400> 79

Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg 
  1               5                  10                  15
Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met 
             20                  25                  30
Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val 
         35                  40                  45
Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met 
     50                  55                  60
Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp 
 65                  70                  75                  80
Leu Gly Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys 
                 85                  90                  95
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val 
             100                105                110
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala 
         115                120                125
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn 
     130                135                140
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu 
 145                150                155                160
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg 
                 165                170                175
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile 
             180                185                190
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly 
         195                200                205



<210> 80
<211> 781
<212> DNA
<213> Rattus norvegicus
<308> AB003991
<400> 80

atggccgag  acgcagaca  gcgtaatga  ctggaggag  tgcagagga  ggctgacca  60
ctggctgat  agtccctgg  aagcacccg  cgcatgctg  agctggtcg  agagagtaa  120
gatgctggc  tcaggactt  ggttatgtt  gatgagcaa  gcgaacaac  cgatcgtgt  180
gaagaaggc  tgaaccata  caaccaaga  atgaaggag  ccgagaaaa  tttaaaaga  240
ttaggcaaa  gctgtggcc  tttcatatg  ccttgtaac  agcttaaat  cagtgatgc  300
tacaaaaaa  cctggggca  taatcagga  ggagtagtg  ccagccagc  tgcccgtgt  360
gtggatgaa  gggagcaga  ggccatcag  ggtggcttc  tccgcaggg  aacaaacga  420
gcccgggaa  atgaaatgg  tgaaaacct  gagcaggtg  gcggcatca  cggaaacct  480
cgtcatatg  ccctagaca  gggcaatga  attgacacc  agaatcgcc  gattgacag  540
atcatggag  aggctgact  caacaaaac  agaattgat  aagccaacc  acgtgcaac  600
aagatgctg  gaagtggtt  aatctgccc  tctgctgtg  tctcctcca  tgttgttgg  660
caagagaga  gagagctcc  tcatgcttc  ctcatggta  tacctagta  gactcacac  720
cacacacac  cacacacac  cacacaggg  tctctcagt  tctgacttc  tttctctcc  780
g  781



<210> 81
<211> 206
<212> PRT
<213> Rattus norvegicus
<308> BAA20151
<400> 81

Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg 
  1               5                  10                  15
Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met 
             20                  25                  30
Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val 
         35                  40                  45
Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met 
     50                  55                  60
Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp 
 65                  70                  75                  80
Leu Gly Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys 
                 85                  90                  95
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val 
             100                105                110
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala 
         115                120                125
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn 
     130                135                140
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu 
 145                150                155                160
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg 
                 165                170                175
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile 
             180                185                190
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly 
         195                200                205



<210> 82
<211> 781
<212> DNA
<213> Rattus norvegicus
<308> AB003991
<400> 82

atggccgag  acgcagaca  gcgtaatga  ctggaggag  tgcagagga  ggctgacca  60
ctggctgat  agtccctgg  aagcacccg  cgcatgctg  agctggtcg  agagagtaa  120
gatgctggc  tcaggactt  ggttatgtt  gatgagcaa  gcgaacaac  cgatcgtgt  180
gaagaaggc  tgaaccata  caaccaaga  atgaaggag  ccgagaaaa  tttaaaaga  240
ttaggcaaa  gctgtggcc  tttcatatg  ccttgtaac  agcttaaat  cagtgatgc  300
tacaaaaaa  cctggggca  taatcagga  ggagtagtg  ccagccagc  tgcccgtgt  360
gtggatgaa  gggagcaga  ggccatcag  ggtggcttc  tccgcaggg  aacaaacga  420
gcccgggaa  atgaaatgg  tgaaaacct  gagcaggtg  gcggcatca  cggaaacct  480
cgtcatatg  ccctagaca  gggcaatga  attgacacc  agaatcgcc  gattgacag  540
atcatggag  aggctgact  caacaaaac  agaattgat  aagccaacc  acgtgcaac  600
aagatgctg  gaagtggtt  aatctgccc  tctgctgtg  tctcctcca  tgttgttgg  660
caagagaga  gagagctcc  tcatgcttc  ctcatggta  tacctagta  gactcacac  720
cacacacac  cacacacac  cacacaggg  tctctcagt  tctgacttc  tttctctcc  780
g  781



<210> 83
<211> 206
<212> PRT
<213> Rattus norvegicus
<308> BAA20151
<400> 83

Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg 
  1               5                  10                  15
Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met 
             20                  25                  30
Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val 
         35                  40                  45
Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met 
     50                  55                  60
Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp 
 65                  70                  75                  80
Leu Gly Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys 
                 85                  90                  95
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val 
             100                105                110
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala 
         115                120                125
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn 
     130                135                140
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu 
 145                150                155                160
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg 
                 165                170                175
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile 
             180                185                190
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly 
         195                200                205



<210> 84
<211> 781
<212> DNA
<213> Rattus norvegicus
<308> AB003991
<400> 84

atggccgag  acgcagaca  gcgtaatga  ctggaggag  tgcagagga  ggctgacca  60
ctggctgat  agtccctgg  aagcacccg  cgcatgctg  agctggtcg  agagagtaa  120
gatgctggc  tcaggactt  ggttatgtt  gatgagcaa  gcgaacaac  cgatcgtgt  180
gaagaaggc  tgaaccata  caaccaaga  atgaaggag  ccgagaaaa  tttaaaaga  240
ttaggcaaa  gctgtggcc  tttcatatg  ccttgtaac  agcttaaat  cagtgatgc  300
tacaaaaaa  cctggggca  taatcagga  ggagtagtg  ccagccagc  tgcccgtgt  360
gtggatgaa  gggagcaga  ggccatcag  ggtggcttc  tccgcaggg  aacaaacga  420
gcccgggaa  atgaaatgg  tgaaaacct  gagcaggtg  gcggcatca  cggaaacct  480
cgtcatatg  ccctagaca  gggcaatga  attgacacc  agaatcgcc  gattgacag  540
atcatggag  aggctgact  caacaaaac  agaattgat  aagccaacc  acgtgcaac  600
aagatgctg  gaagtggtt  aatctgccc  tctgctgtg  tctcctcca  tgttgttgg  660
caagagaga  gagagctcc  tcatgcttc  ctcatggta  tacctagta  gactcacac  720
cacacacac  cacacacac  cacacaggg  tctctcagt  tctgacttc  tttctctcc  780
g  781



<210> 85
<211> 206
<212> PRT
<213> Rattus norvegicus
<308> BAA20151
<400> 85

Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg 
  1               5                  10                  15
Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met 
             20                  25                  30
Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val 
         35                  40                  45
Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met 
     50                  55                  60
Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp 
 65                  70                  75                  80
Leu Gly Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys 
                 85                  90                  95
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val 
             100                105                110
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala 
         115                120                125
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn 
     130                135                140
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu 
 145                150                155                160
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg 
                 165                170                175
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile 
             180                185                190
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly 
         195                200                205



<210> 86
<211> 621
<212> DNA
<213> Rattus norvegicus
<308> AB003992
<400> 86

atggccgag  acgcagaca  gcgtaatga  ctggaggag  tgcagagga  ggctgacca  60
ctggctgat  agtccctgg  aagcacccg  cgcatgctg  agctggtcg  agagagtaa  120
gatgctggc  tcaggactt  ggttatgtt  gatgagcaa  gcgaacaac  ggaacgcat  180
gaggaaggg  tggaccaaa  caataagga  atgaaagaa  cagaaaaga  tttgacgga  240
ctaggaaaa  tctgcgggc  ttgtgtgtg  ccctgtaac  agcttaaat  cagtgatgc  300
tacaaaaaa  cctggggca  taatcagga  ggagtagtg  ccagccagc  tgcccgtgt  360
gtggatgaa  gggagcaga  ggccatcag  ggtggcttc  tccgcaggg  aacaaacga  420
gcccgggaa  atgaaatgg  tgaaaacct  gagcaggtg  gcggcatca  cggaaacct  480
cgtcatatg  ccctagaca  gggcaatga  attgacacc  agaatcgcc  gattgacag  540
atcatggag  aggctgact  caacaaaac  agaattgat  aagccaacc  acgtgcaac  600
aagatgctg  gaagtggtt  a  621



<210> 87
<211> 206
<212> PRT
<213> Rattus norvegicus
<308> BAA20152
<400> 87

Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg 
  1               5                  10                  15
Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met 
             20                  25                  30
Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val 
         35                  40                  45
Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met 
     50                  55                  60
Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp 
 65                  70                  75                  80
Leu Gly Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys 
                 85                  90                  95
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val 
             100                105                110
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala 
         115                120                125
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn 
     130                135                140
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu 
 145                150                155                160
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg 
                 165                170                175
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile 
             180                185                190
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly 
         195                200                205



<210> 88
<211> 2053
<212> DNA
<213> Homo sapiens
<308> NM_003081
<400> 88

catctttga  gagggcaga  ctcacgttg  attgaagac  aaacctcgg  gaggtcagg  60
gctgtcttt  cttccctcc  tgctcggcg  ctccaccac  gttgcaacc  gcagaggcc  120
ggagaacac  accctcccg  gaagcccag  tccagagcc  aacccgtca  tgacccccc  180
gcccaggcg  ccagccact  cccaccgct  ccatggccg  agacgcaga  atgcgcaat  240
agctggagg  gatgcagcg  agggctgac  agttggctg  tgagtcgct  gaaagcacc  300
gtcgtatgc  gcaactggt  gaagagagt  aagatgctg  tatcaggac  ttggttatg  360
tggatgaac  aggagaaca  ctcgatcgt  tcgaagaag  catgaacca  atcaaccaa  420
acatgaagg  ggctgagaa  aatttaaaa  atttaggga  atgctgtgg  cttttcata  480
gtccttgta  caagcttaa  tcaagtgat  cttacaaaa  agcctgggg  aataatcag  540
acggagtgg  ggccagcca  cctgctcgt  tagtggacg  acgggagca  atggccatc  600
gtggcggct  catccgcag  gtaacaaat  atgcccgag  aaatgaaat  gatgaaaac  660
tagagcagg  gagcggcat  atcgggaac  tccgtcaca  ggccctgga  atgggcaat  720
agatcgata  acagaatcg  cagatcgac  ggatcatgg  gaaggctga  tccaacaaa  780
ccagaattg  tgaggccaa  caacgtgca  caaagatgc  gggaagtgg  taagtgtgc  840
cacccgtgt  ctcctccaa  tgctgtcgg  caagatagc  ccttcatgc  tttctcatg  900
tattatcta  taggtctgc  cacataaca  acatcagtc  acccccatt  tgaatgttg  960
cctgtgtca  ctgtcagct  cccaacaat  ctttgtgtc  tttgttctc  cttggtctc  1020
ttctttcca  aggttgtac  tagtggtca  ttggtggct  taactcctt  atgtcttga  1080
tttcatttt  cattttctc  cctcggtgg  atttgctga  taacaacaa  ttaggaatg  1140
tcaatgtgc  gttgattct  tcaatccac  gtattgttc  tgtaaaact  tgacattcc  1200
cagagttac  gccacggtc  tttgagtgt  aggctctga  tctctcaaa  tgtgccgtc  1260
ttggttcct  atggctgtt  tctgtcttt  tgatttcat  attagacaa  gtggaatta  1320
ataacaggc  ttgcactaa  agtgatgtg  tttatgcat  tatgcatga  aactaaata  1380
atttttaga  tcctactta  acaaaaact  tccatgaca  tagcatact  atgagacaa  1440
acacacaca  acaaaacaa  agcaacaac  acagaacaa  aacaaagca  gctcagtat  1500
gagacactg  caagattaa  ttataccag  aaaagtgca  tagtgtcac  tttttcctg  1560
caatatata  agacttcta  atcataatc  tcctttttt  aaaaaaaga  ttttaaaaa  1620
gatggattt  acacactca  catttaatc  tttccagca  aatatatgt  tggctgaaa  1680
tatgtcaaa  ggatgtaat  tagggtttg  ttgctgctt  tgatggcta  gttttggag  1740
gagcaatct  gctgtgaaa  agtgtggat  taaatttta  aaggctgac  cttactaac  1800
accatttcc  ctgtggttt  ttatcagta  aattctttg  tgcttaatc  agagctatg  1860
acaccaaat  gctgagatg  ttagtagct  ataaagaaa  cttttaaaa  aataatata  1920
atgaatgaa  tataaactg  gagataaat  tcattatag  atgtaatat  aaattcctc  1980
tgtctcctc  gtcagtttg  gaagtgatt  acattttgt  gctagttta  aattattaa  2040
aattataga  tcc  2053



<210> 89
<211> 206
<212> PRT
<213> Homo sapiens
<308> P13795
<400> 89

Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg 
  1               5                  10                  15
Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met 
             20                  25                  30
Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val 
         35                  40                  45
Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met 
     50                  55                  60
Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp 
 65                  70                  75                  80
Leu Gly Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys 
                 85                  90                  95
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val 
             100                105                110
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala 
         115                120                125
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn 
     130                135                140
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu 
 145                150                155                160
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg 
                 165                170                175
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile 
             180                185                190
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly 
         195                200                205



<210> 90
<211> 621
<212> DNA
<213> Rattus norvegicus
<308> AB003992
<400> 90

atggccgag  acgcagaca  gcgtaatga  ctggaggag  tgcagagga  ggctgacca  60
ctggctgat  agtccctgg  aagcacccg  cgcatgctg  agctggtcg  agagagtaa  120
gatgctggc  tcaggactt  ggttatgtt  gatgagcaa  gcgaacaac  ggaacgcat  180
gaggaaggg  tggaccaaa  caataagga  atgaaagaa  cagaaaaga  tttgacgga  240
ctaggaaaa  tctgcgggc  ttgtgtgtg  ccctgtaac  agcttaaat  cagtgatgc  300
tacaaaaaa  cctggggca  taatcagga  ggagtagtg  ccagccagc  tgcccgtgt  360
gtggatgaa  gggagcaga  ggccatcag  ggtggcttc  tccgcaggg  aacaaacga  420
gcccgggaa  atgaaatgg  tgaaaacct  gagcaggtg  gcggcatca  cggaaacct  480
cgtcatatg  ccctagaca  gggcaatga  attgacacc  agaatcgcc  gattgacag  540
atcatggag  aggctgact  caacaaaac  agaattgat  aagccaacc  acgtgcaac  600
aagatgctg  gaagtggtt  a  621



<210> 91
<211> 206
<212> PRT
<213> Rattus norvegicus
<308> BAA20152
<400> 91

Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg 
  1               5                  10                  15
Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met 
             20                  25                  30
Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val 
         35                  40                  45
Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met 
     50                  55                  60
Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp 
 65                  70                  75                  80
Leu Gly Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys 
                 85                  90                  95
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val 
             100                105                110
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala 
         115                120                125
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn 
     130                135                140
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu 
 145                150                155                160
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg 
                 165                170                175
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile 
             180                185                190
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly 
         195                200                205



<210> 92
<211> 2053
<212> DNA
<213> Homo sapiens
<308> NM_003081
<400> 92

catctttga  gagggcaga  ctcacgttg  attgaagac  aaacctcgg  gaggtcagg  60
gctgtcttt  cttccctcc  tgctcggcg  ctccaccac  gttgcaacc  gcagaggcc  120
ggagaacac  accctcccg  gaagcccag  tccagagcc  aacccgtca  tgacccccc  180
gcccaggcg  ccagccact  cccaccgct  ccatggccg  agacgcaga  atgcgcaat  240
agctggagg  gatgcagcg  agggctgac  agttggctg  tgagtcgct  gaaagcacc  300
gtcgtatgc  gcaactggt  gaagagagt  aagatgctg  tatcaggac  ttggttatg  360
tggatgaac  aggagaaca  ctcgatcgt  tcgaagaag  catgaacca  atcaaccaa  420
acatgaagg  ggctgagaa  aatttaaaa  atttaggga  atgctgtgg  cttttcata  480
gtccttgta  caagcttaa  tcaagtgat  cttacaaaa  agcctgggg  aataatcag  540
acggagtgg  ggccagcca  cctgctcgt  tagtggacg  acgggagca  atggccatc  600
gtggcggct  catccgcag  gtaacaaat  atgcccgag  aaatgaaat  gatgaaaac  660
tagagcagg  gagcggcat  atcgggaac  tccgtcaca  ggccctgga  atgggcaat  720
agatcgata  acagaatcg  cagatcgac  ggatcatgg  gaaggctga  tccaacaaa  780
ccagaattg  tgaggccaa  caacgtgca  caaagatgc  gggaagtgg  taagtgtgc  840
cacccgtgt  ctcctccaa  tgctgtcgg  caagatagc  ccttcatgc  tttctcatg  900
tattatcta  taggtctgc  cacataaca  acatcagtc  acccccatt  tgaatgttg  960
cctgtgtca  ctgtcagct  cccaacaat  ctttgtgtc  tttgttctc  cttggtctc  1020
ttctttcca  aggttgtac  tagtggtca  ttggtggct  taactcctt  atgtcttga  1080
tttcatttt  cattttctc  cctcggtgg  atttgctga  taacaacaa  ttaggaatg  1140
tcaatgtgc  gttgattct  tcaatccac  gtattgttc  tgtaaaact  tgacattcc  1200
cagagttac  gccacggtc  tttgagtgt  aggctctga  tctctcaaa  tgtgccgtc  1260
ttggttcct  atggctgtt  tctgtcttt  tgatttcat  attagacaa  gtggaatta  1320
ataacaggc  ttgcactaa  agtgatgtg  tttatgcat  tatgcatga  aactaaata  1380
atttttaga  tcctactta  acaaaaact  tccatgaca  tagcatact  atgagacaa  1440
acacacaca  acaaaacaa  agcaacaac  acagaacaa  aacaaagca  gctcagtat  1500
gagacactg  caagattaa  ttataccag  aaaagtgca  tagtgtcac  tttttcctg  1560
caatatata  agacttcta  atcataatc  tcctttttt  aaaaaaaga  ttttaaaaa  1620
gatggattt  acacactca  catttaatc  tttccagca  aatatatgt  tggctgaaa  1680
tatgtcaaa  ggatgtaat  tagggtttg  ttgctgctt  tgatggcta  gttttggag  1740
gagcaatct  gctgtgaaa  agtgtggat  taaatttta  aaggctgac  cttactaac  1800
accatttcc  ctgtggttt  ttatcagta  aattctttg  tgcttaatc  agagctatg  1860
acaccaaat  gctgagatg  ttagtagct  ataaagaaa  cttttaaaa  aataatata  1920
atgaatgaa  tataaactg  gagataaat  tcattatag  atgtaatat  aaattcctc  1980
tgtctcctc  gtcagtttg  gaagtgatt  acattttgt  gctagttta  aattattaa  2040
aattataga  tcc  2053



<210> 93
<211> 206
<212> PRT
<213> Homo sapiens
<308> P13795
<400> 93

Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg 
  1               5                  10                  15
Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met 
             20                  25                  30
Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val 
         35                  40                  45
Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met 
     50                  55                  60
Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp 
 65                  70                  75                  80
Leu Gly Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys 
                 85                  90                  95
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val 
             100                105                110
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala 
         115                120                125
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn 
     130                135                140
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu 
 145                150                155                160
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg 
                 165                170                175
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile 
             180                185                190
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly 
         195                200                205



<210> 94
<211> 2015
<212> DNA
<213> Rattus norvegicus
<308> AB004096
<400> 94

gtgagagtt  ctttatacg  tacacattc  tcctctaag  cgagaccac  ccaggctga  60
agtagtgaa  attttaaaa  ttactctga  gaaaacttt  tttttaaaa  agggcgcca  120
cgttgtatt  gagaaaatt  tgcctatgt  caaattaag  caatttggt  cactatgct  180
cgtttatat  aatttgacc  catcaatgg  tattttccc  gtgtgaatt  tacaacaat  240
attcatacc  cagaaaacc  agtaatccg  tacaaacga  gatcaaaat  aagaaagga  300
caaggagcc  gtgtggaga  gggactgca  gctgcagct  ggcagagaa  gaagctttg  360
cacagcttt  atactgtac  gttttttaa  tgtgtggtt  tgaaagcca  tttgatttt  420
atgttttat  aactcggtg  tttttgtca  acctaatgg  atttgaaac  gttataata  480
ttctgatag  atttcaggg  agccaagtt  atgttagaa  tcgtttagg  gagcctcgg  540
attcagaga  gatacagaa  atagcatcc  ggtaactaa  ttcagaagc  cacgttgcc  600
tagggagat  ccggcttgg  actagtttg  gaagtttta  gcctggtca  atgctacag  660
ggcaatggg  cattggtgt  gttgggcca  ttctgtgcg  aaagatgtg  gagggtgaa  720
gataagttt  ctgcgaagc  ctagatggt  tgagtgccc  ttgtagtgt  aactgagag  780
accactcca  cgagatggc  gcaatcttg  accttatct  gataacctt  tttcctaaa  840
ataataaat  ctaaagagt  cttatgtta  tggttccag  aaaatccaa  atcaaatcc  900
tgtggaatt  ttaatttta  ttaaaaaaa  aaaaaaaca  gtaccatga  tttaaaagt  960
tatgattct  agcttagtg  attctggcc  tgagattga  gaatgggga  atggtatca  1020
tgcccgtgt  ctttggagg  tgtgctcag  agccaacct  acagattgt  accatgggc  1080
taattctga  ctgcccata  tctgtatta  gaatcaaga  atctgttgc  gggtgtggt  1140
ctgcacacc  gtaatacta  tgctcgggc  gaggcagaa  gattgagag  ttgaggcca  1200
cctagagct  catagcaag  cttaacacc  tccccaaaa  aaaaccttt  ttctctaaa  1260
tatgtgtac  ggctggtct  aggtgacaa  ctgacacac  ctagggtca  cagagaaaa  1320
ggaacctca  ttgaggaaa  gctgtaagg  tgcttagtg  tcaatgaga  agggcccag  1380
ccactgtgg  tggttccac  cctaggctg  tcatcctgg  tcctaagaa  gcaggctga  1440
taagacacc  ggagcaaga  agtaagcag  atccttcat  gcctctgca  cagctcctg  1500
cttaggttc  tgacccgct  gagttcccg  cctgacttt  tttgataat  aacagtagt  1560
tggaagtgt  agccaaata  cccaccccc  ccctcccaa  ttgcttttt  ctcatggtg  1620
tttgtagca  tagaaaccc  aactgttac  gctgtaaga  gcttttgaa  actcttcaa  1680
tgaaggccc  aatctctgc  gttaaaggt  tcagattaa  attctctat  agaaaagtt  1740
tgctggtct  tattcatgg  tttgaagct  tgcttcagt  agtacagtt  aagaggtct  1800
ggaatgggg  tggggattt  gctcagtgg  agagcgctt  cctaggaag  gcaaggccc  1860
gggttcggt  cccagctcc  aaaaaaaga  caaaaaaaa  agaggtctg  gaattcaga  1920
acttagatc  tatttgcct  aaatcggct  ccttcagta  tacctttag  tatttagat  1980
agtcactct  gtgatccgt  gacctgcag  tcgac  2015



<210> 95
<211> 503
<212> PRT
<213> Rattus norvegicus
<308> BAA20354
<400> 95

Met Val Leu Leu Gly Leu Leu Gln Ser Gly Gly Ser Val Leu Gly Gln 
  1               5                  10                  15
Ala Met Glu Gln Val Thr Gly Gly Asn Leu Leu Ser Thr Leu Leu Ile 
             20                  25                  30
Ala Cys Ala Phe Thr Leu Ser Leu Val Tyr Leu Phe Arg Leu Ala Val 
         35                  40                  45
Gly His Met Val Gln Leu Pro Ala Gly Ala Lys Ser Pro Pro Tyr Ile 
     50                  55                  60
Tyr Ser Pro Ile Pro Phe Leu Gly His Ala Ile Ala Phe Gly Lys Ser 
 65                  70                  75                  80
Pro Ile Glu Phe Leu Glu Asn Ala Tyr Glu Lys Tyr Gly Pro Val Phe 
                 85                  90                  95
Ser Phe Thr Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp 
             100                105                110
Ala Ala Ala Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu 
         115                120                125
Glu Val Tyr Gly Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala 
     130                135                140
Tyr Asp Val Pro Asn Ala Val Phe Leu Glu Gln Lys Lys Ile Leu Lys 
 145                150                155                160
Ser Gly Leu Asn Ile Ala His Phe Lys Gln Tyr Val Ser Ile Ile Glu 
                 165                170                175
Lys Glu Ala Lys Glu Tyr Phe Lys Ser Trp Gly Glu Ser Gly Glu Arg 
             180                185                190
Asn Val Phe Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His 
         195                200                205
Cys Leu His Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala 
     210                215                220
Gln Leu Tyr Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu 
 225                230                235                240
Leu Pro Gly Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala 
                 245                250                255
His Arg Glu Ile Lys Asn Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg 
             260                265                270
Leu Ser Lys Glu Pro Ala Glu Asp Ile Leu Gln Thr Leu Leu Asp Ser 
         275                280                285
Thr Tyr Lys Asp Gly Arg Pro Leu Thr Asp Asp Glu Ile Ala Gly Met 
     290                295                300
Leu Ile Gly Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser 
 305                310                315                320
Ala Trp Met Gly Phe Phe Leu Ala Arg Asp Lys Pro Leu Gln Asp Lys 
                 325                330                335
Cys Tyr Leu Glu Gln Lys Thr Val Cys Gly Glu Asp Leu Pro Pro Leu 
             340                345                350
Thr Tyr Glu Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys 
         355                360                365
Glu Thr Leu Arg Leu Arg Pro Pro Ile Met Thr Met Met Arg Met Ala 
     370                375                380
Lys Thr Pro Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln 
 385                390                395                400
Val Cys Val Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val 
                 405                410                415
Glu Arg Leu Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala 
             420                425                430
Ser Gly Glu Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg 
         435                440                445
Cys Ile Gly Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser 
     450                455                460
Thr Met Leu Arg Leu Tyr Glu Phe Asp Leu Ile Asn Gly Tyr Phe Pro 
 465                470                475                480
Ser Val Asn Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile 
                 485                490                495
Arg Tyr Lys Arg Arg Ser Lys 
             500



<210> 96
<211> 3172
<212> DNA
<213> Homo sapiens
<308> U23942
<400> 96

gctgggttt  gtaggagac  tggggcaag  ccccctgtg  acgaccatc  gccagcttc  60
ctcgttccg  cgattggga  gagcggtgg  gacctcggc  ttcagtgtt  ccgacggag  120
gaatggcgg  ggcggctgg  atgctgctg  tgggcttgc  gcaggcggg  gggtcggtg  180
tgggccagg  gatggagaa  gtgacaggc  gcaacctct  gtccatgct  ctgatcgcc  240
gcgccttca  cctcagcct  gtctacctg  tccgtctgg  cgccggcca  ctggtccag  300
tgcccgcag  ggtgaaaag  cctccatac  ttttctccc  aattccatt  cttgggcat  360
ccatagcat  tgggaaaag  ccaattgaa  ttctagaaa  tgcatatga  aagtatgga  420
ctgtattta  ttttaccat  gtaggcaag  catttactt  ccttctggg  agtgatgct  480
ctgcactgc  ttttaatag  aaaaatgaa  acctgaatg  agaagatgt  tacagtcgc  540
tgacaacac  tgtgtttgg  aagggagtt  catacgatg  gcctaatcc  gttttcttg  600
agcagaaga  aatgttaaa  agtggcctt  acatagccc  ctttaaaca  catgtttct  660
taattgaaa  agaaacaaa  gaatacttt  agagttggg  agaaagtgg  gaaaaaaat  720
tgtttgaag  tctttctga  ctcataatt  taacagcta  ccattgttt  catggaaag  780
aaatcagaa  tcaactcaa  gaaaaggta  cacagctgt  tgcagattt  gatggaggt  840
tcagccatg  agcctggct  ttaccaggt  ggctgcctt  gcctagttt  agacgcagg  900
acagagctc  tcgggaaat  aaggatatt  tctataagg  aatccagaa  cgcagacag  960
ctcaagaaa  aattgatga  attctccaa  ctttactag  tgctacata  aaggatggg  1020
gtcctttga  tgatgatga  gtagcaggg  tgcttattg  attactctt  gcagggcag  1080
atacatcct  aactactag  gcttggatg  gcttctttt  ggccagaga  aaaacactt  1140
aaaaaaaat  ttatttaga  cagaaaaca  tctgtggag  gaatctgcc  cctttaact  1200
atgaccagc  caaggatct  aatttactt  atcgctgta  aaaagaaac  ttaagactt  1260
gacctccta  aatgatcat  atgagaatg  ccagaactc  tcagactgt  gcagggtat  1320
ccattcctc  aggacatca  gtgtgtgtt  ctcccactg  caatcaaag  cttaaagac  1380
catgggtag  acgcctgga  tttaatcct  atcgctact  acaggataa  ccagcatca  1440
gggaaaagt  tgcctatgt  ccatttgga  ctgggcgtc  tcgttgtat  ggggaaaat  1500
ttgcctatg  tcaaattaa  acaatttgg  ccactatgc  tcgtttata  gaatttgat  1560
tcattgatg  atactttcc  actgtgaat  atacaacta  gattcacac  cctgagaac  1620
cagttatcc  ttacaaacg  agatcaaaa  gaaaaaggt  gcaaggaac  aatatatgt  1680
attatcact  taagccaca  aggcattcg  agagaatga  gtgtacaaa  caactcttg  1740
agtttactg  ttttttaag  gtgtaattc  aaaagccag  ttatgattt  ggattttgt  1800
aactgaatg  ttctatcaa  tataatagc  tttgacaca  tttctaata  ttatgatac  1860
tatacatgt  ctttcagga  gttccttgg  gaaacaatt  ttgaggggg  atctaggta  1920
ttggcagat  ctaaataat  taatttcca  atagtaatt  taagagtac  catcgctct  1980
gccaaataa  ttcagggta  tcaaatctt  gactagtcc  gcaaggtat  aagaataaa  2040
atcccagtg  gatacttgg  aaccacagt  tattattat  tatctgggc  attattgtg  2100
gtgtgagga  ggaagggta  ggaataatc  aacatctaa  gccttgaat  agagaatac  2160
aattgtttt  gtatgatga  actcagaaa  ggagatatt  taggaaaaa  aaatccttt  2220
gaattttaa  taaaatcac  gcatatggg  aattaagag  tccaggacc  tatttgata  2280
gagttccta  aaataatgt  attattaat  ctaaagact  ctcatgtat  ttgatctaa  2340
tactaaata  attacatat  tatttacct  ataaatatg  atctagttc  acaaggtca  2400
atttatgtg  aagtccaaa  tcaagtcct  aggggataa  tttgttttg  gctcagttg  2460
tccctgctt  ctttttttt  ttttttttt  tttgagatg  agtctcgct  tgttgccca  2520
gctggagtg  agtggtgcg  tctcagctc  ctgcatcct  tgcctcccg  gttcaagca  2580
ttctctgcc  cagcctccc  agtagttgg  attacaggc  cctgccacc  tgcctggct  2640
attttttgt  tttttagta  agacggggg  ttcactatg  tggctaggc  ggtcttgaa  2700
tcctgagcc  cgtgagtcc  cccgccttg  cctcccaaa  tgctgggat  acaggcatg  2760
gccaccgca  ctggccttc  ctgcttcct  tctagaatc  aattaggga  gtttgttac  2820
actcatatt  attaaaaca  ttaacaaac  tttttcttt  taaaatgtg  gatcagtga  2880
ctctggttt  aagataatc  gaaacaagg  ccttgggag  aataaaatt  gtcacattc  2940
gtaaagcac  ttctgttta  gaatcaact  atctcaaat  gtaactcgg  gcctaacta  3000
atgagatgg  tgaaaaaat  ccacatcgt  tgttttcac  aggtgatgc  aaaatattt  3060
gctttatgt  tattacagt  ctttttaaa  cactggaag  ctcatgtta  actctaatt  3120
tgaaggcag  atctctgct  atttttcag  ttaaaattc  ctttgaaaa  at  3172



<210> 97
<211> 503
<212> PRT
<213> Homo sapiens
<308> Q16850
<400> 97

Met Leu Leu Leu Gly Leu Leu Gln Ala Gly Gly Ser Val Leu Gly Gln 
  1               5                  10                  15
Ala Met Glu Lys Val Thr Gly Gly Asn Leu Leu Ser Met Leu Leu Ile 
             20                  25                  30
Ala Cys Ala Phe Thr Leu Ser Leu Val Tyr Leu Ile Arg Leu Ala Ala 
         35                  40                  45
Gly His Leu Val Gln Leu Pro Ala Gly Val Lys Ser Pro Pro Tyr Ile 
     50                  55                  60
Phe Ser Pro Ile Pro Phe Leu Gly His Ala Ile Ala Phe Gly Lys Ser 
 65                  70                  75                  80
Pro Ile Glu Phe Leu Glu Asn Ala Tyr Glu Lys Tyr Gly Pro Val Phe 
                 85                  90                  95
Ser Phe Thr Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp 
             100                105                110
Ala Ala Ala Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu 
         115                120                125
Asp Val Tyr Ser Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala 
     130                135                140
Tyr Asp Val Pro Asn Pro Val Phe Leu Glu Gln Lys Lys Met Leu Lys 
 145                150                155                160
Ser Gly Leu Asn Ile Ala His Phe Lys Gln His Val Ser Ile Ile Glu 
                 165                170                175
Lys Glu Thr Lys Glu Tyr Phe Glu Ser Trp Gly Glu Ser Gly Glu Lys 
             180                185                190
Asn Val Phe Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His 
         195                200                205
Cys Leu His Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala 
     210                215                220
Gln Leu Tyr Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu 
 225                230                235                240
Leu Pro Gly Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala 
                 245                250                255
His Arg Glu Ile Lys Asp Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg 
             260                265                270
Gln Ser Gln Glu Lys Ile Asp Asp Ile Leu Gln Thr Leu Leu Asp Ala 
         275                280                285
Thr Tyr Lys Asp Gly Arg Pro Leu Thr Asp Asp Glu Val Ala Gly Met 
     290                295                300
Leu Ile Gly Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser 
 305                310                315                320
Ala Trp Met Gly Phe Phe Leu Ala Arg Asp Lys Thr Leu Gln Lys Lys 
                 325                330                335
Cys Tyr Leu Glu Gln Lys Thr Val Cys Gly Glu Asn Leu Pro Pro Leu 
             340                345                350
Thr Tyr Asp Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys 
         355                360                365
Glu Thr Leu Arg Leu Arg Pro Pro Ile Met Ile Met Met Arg Met Ala 
     370                375                380
Arg Thr Pro Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln 
 385                390                395                400
Val Cys Val Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val 
                 405                410                415
Glu Arg Leu Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala 
             420                425                430
Ser Gly Glu Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg 
         435                440                445
Cys Ile Gly Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser 
     450                455                460
Thr Met Leu Arg Leu Tyr Glu Phe Asp Leu Ile Asp Gly Tyr Phe Pro 
 465                470                475                480
Thr Val Asn Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile 
                 485                490                495
Arg Tyr Lys Arg Arg Ser Lys 
             500



<210> 98
<211> 2015
<212> DNA
<213> Rattus norvegicus
<308> AB004096
<400> 98

gtgagagtt  ctttatacg  tacacattc  tcctctaag  cgagaccac  ccaggctga  60
agtagtgaa  attttaaaa  ttactctga  gaaaacttt  tttttaaaa  agggcgcca  120
cgttgtatt  gagaaaatt  tgcctatgt  caaattaag  caatttggt  cactatgct  180
cgtttatat  aatttgacc  catcaatgg  tattttccc  gtgtgaatt  tacaacaat  240
attcatacc  cagaaaacc  agtaatccg  tacaaacga  gatcaaaat  aagaaagga  300
caaggagcc  gtgtggaga  gggactgca  gctgcagct  ggcagagaa  gaagctttg  360
cacagcttt  atactgtac  gttttttaa  tgtgtggtt  tgaaagcca  tttgatttt  420
atgttttat  aactcggtg  tttttgtca  acctaatgg  atttgaaac  gttataata  480
ttctgatag  atttcaggg  agccaagtt  atgttagaa  tcgtttagg  gagcctcgg  540
attcagaga  gatacagaa  atagcatcc  ggtaactaa  ttcagaagc  cacgttgcc  600
tagggagat  ccggcttgg  actagtttg  gaagtttta  gcctggtca  atgctacag  660
ggcaatggg  cattggtgt  gttgggcca  ttctgtgcg  aaagatgtg  gagggtgaa  720
gataagttt  ctgcgaagc  ctagatggt  tgagtgccc  ttgtagtgt  aactgagag  780
accactcca  cgagatggc  gcaatcttg  accttatct  gataacctt  tttcctaaa  840
ataataaat  ctaaagagt  cttatgtta  tggttccag  aaaatccaa  atcaaatcc  900
tgtggaatt  ttaatttta  ttaaaaaaa  aaaaaaaca  gtaccatga  tttaaaagt  960
tatgattct  agcttagtg  attctggcc  tgagattga  gaatgggga  atggtatca  1020
tgcccgtgt  ctttggagg  tgtgctcag  agccaacct  acagattgt  accatgggc  1080
taattctga  ctgcccata  tctgtatta  gaatcaaga  atctgttgc  gggtgtggt  1140
ctgcacacc  gtaatacta  tgctcgggc  gaggcagaa  gattgagag  ttgaggcca  1200
cctagagct  catagcaag  cttaacacc  tccccaaaa  aaaaccttt  ttctctaaa  1260
tatgtgtac  ggctggtct  aggtgacaa  ctgacacac  ctagggtca  cagagaaaa  1320
ggaacctca  ttgaggaaa  gctgtaagg  tgcttagtg  tcaatgaga  agggcccag  1380
ccactgtgg  tggttccac  cctaggctg  tcatcctgg  tcctaagaa  gcaggctga  1440
taagacacc  ggagcaaga  agtaagcag  atccttcat  gcctctgca  cagctcctg  1500
cttaggttc  tgacccgct  gagttcccg  cctgacttt  tttgataat  aacagtagt  1560
tggaagtgt  agccaaata  cccaccccc  ccctcccaa  ttgcttttt  ctcatggtg  1620
tttgtagca  tagaaaccc  aactgttac  gctgtaaga  gcttttgaa  actcttcaa  1680
tgaaggccc  aatctctgc  gttaaaggt  tcagattaa  attctctat  agaaaagtt  1740
tgctggtct  tattcatgg  tttgaagct  tgcttcagt  agtacagtt  aagaggtct  1800
ggaatgggg  tggggattt  gctcagtgg  agagcgctt  cctaggaag  gcaaggccc  1860
gggttcggt  cccagctcc  aaaaaaaga  caaaaaaaa  agaggtctg  gaattcaga  1920
acttagatc  tatttgcct  aaatcggct  ccttcagta  tacctttag  tatttagat  1980
agtcactct  gtgatccgt  gacctgcag  tcgac  2015



<210> 99
<211> 503
<212> PRT
<213> Rattus norvegicus
<308> BAA20354
<400> 99

Met Val Leu Leu Gly Leu Leu Gln Ser Gly Gly Ser Val Leu Gly Gln 
  1               5                  10                  15
Ala Met Glu Gln Val Thr Gly Gly Asn Leu Leu Ser Thr Leu Leu Ile 
             20                  25                  30
Ala Cys Ala Phe Thr Leu Ser Leu Val Tyr Leu Phe Arg Leu Ala Val 
         35                  40                  45
Gly His Met Val Gln Leu Pro Ala Gly Ala Lys Ser Pro Pro Tyr Ile 
     50                  55                  60
Tyr Ser Pro Ile Pro Phe Leu Gly His Ala Ile Ala Phe Gly Lys Ser 
 65                  70                  75                  80
Pro Ile Glu Phe Leu Glu Asn Ala Tyr Glu Lys Tyr Gly Pro Val Phe 
                 85                  90                  95
Ser Phe Thr Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp 
             100                105                110
Ala Ala Ala Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu 
         115                120                125
Glu Val Tyr Gly Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala 
     130                135                140
Tyr Asp Val Pro Asn Ala Val Phe Leu Glu Gln Lys Lys Ile Leu Lys 
 145                150                155                160
Ser Gly Leu Asn Ile Ala His Phe Lys Gln Tyr Val Ser Ile Ile Glu 
                 165                170                175
Lys Glu Ala Lys Glu Tyr Phe Lys Ser Trp Gly Glu Ser Gly Glu Arg 
             180                185                190
Asn Val Phe Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His 
         195                200                205
Cys Leu His Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala 
     210                215                220
Gln Leu Tyr Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu 
 225                230                235                240
Leu Pro Gly Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala 
                 245                250                255
His Arg Glu Ile Lys Asn Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg 
             260                265                270
Leu Ser Lys Glu Pro Ala Glu Asp Ile Leu Gln Thr Leu Leu Asp Ser 
         275                280                285
Thr Tyr Lys Asp Gly Arg Pro Leu Thr Asp Asp Glu Ile Ala Gly Met 
     290                295                300
Leu Ile Gly Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser 
 305                310                315                320
Ala Trp Met Gly Phe Phe Leu Ala Arg Asp Lys Pro Leu Gln Asp Lys 
                 325                330                335
Cys Tyr Leu Glu Gln Lys Thr Val Cys Gly Glu Asp Leu Pro Pro Leu 
             340                345                350
Thr Tyr Glu Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys 
         355                360                365
Glu Thr Leu Arg Leu Arg Pro Pro Ile Met Thr Met Met Arg Met Ala 
     370                375                380
Lys Thr Pro Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln 
 385                390                395                400
Val Cys Val Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val 
                 405                410                415
Glu Arg Leu Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala 
             420                425                430
Ser Gly Glu Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg 
         435                440                445
Cys Ile Gly Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser 
     450                455                460
Thr Met Leu Arg Leu Tyr Glu Phe Asp Leu Ile Asn Gly Tyr Phe Pro 
 465                470                475                480
Ser Val Asn Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile 
                 485                490                495
Arg Tyr Lys Arg Arg Ser Lys 
             500



<210> 100
<211> 3172
<212> DNA
<213> Homo sapiens
<308> U23942
<400> 100

gctgggttt  gtaggagac  tggggcaag  ccccctgtg  acgaccatc  gccagcttc  60
ctcgttccg  cgattggga  gagcggtgg  gacctcggc  ttcagtgtt  ccgacggag  120
gaatggcgg  ggcggctgg  atgctgctg  tgggcttgc  gcaggcggg  gggtcggtg  180
tgggccagg  gatggagaa  gtgacaggc  gcaacctct  gtccatgct  ctgatcgcc  240
gcgccttca  cctcagcct  gtctacctg  tccgtctgg  cgccggcca  ctggtccag  300
tgcccgcag  ggtgaaaag  cctccatac  ttttctccc  aattccatt  cttgggcat  360
ccatagcat  tgggaaaag  ccaattgaa  ttctagaaa  tgcatatga  aagtatgga  420
ctgtattta  ttttaccat  gtaggcaag  catttactt  ccttctggg  agtgatgct  480
ctgcactgc  ttttaatag  aaaaatgaa  acctgaatg  agaagatgt  tacagtcgc  540
tgacaacac  tgtgtttgg  aagggagtt  catacgatg  gcctaatcc  gttttcttg  600
agcagaaga  aatgttaaa  agtggcctt  acatagccc  ctttaaaca  catgtttct  660
taattgaaa  agaaacaaa  gaatacttt  agagttggg  agaaagtgg  gaaaaaaat  720
tgtttgaag  tctttctga  ctcataatt  taacagcta  ccattgttt  catggaaag  780
aaatcagaa  tcaactcaa  gaaaaggta  cacagctgt  tgcagattt  gatggaggt  840
tcagccatg  agcctggct  ttaccaggt  ggctgcctt  gcctagttt  agacgcagg  900
acagagctc  tcgggaaat  aaggatatt  tctataagg  aatccagaa  cgcagacag  960
ctcaagaaa  aattgatga  attctccaa  ctttactag  tgctacata  aaggatggg  1020
gtcctttga  tgatgatga  gtagcaggg  tgcttattg  attactctt  gcagggcag  1080
atacatcct  aactactag  gcttggatg  gcttctttt  ggccagaga  aaaacactt  1140
aaaaaaaat  ttatttaga  cagaaaaca  tctgtggag  gaatctgcc  cctttaact  1200
atgaccagc  caaggatct  aatttactt  atcgctgta  aaaagaaac  ttaagactt  1260
gacctccta  aatgatcat  atgagaatg  ccagaactc  tcagactgt  gcagggtat  1320
ccattcctc  aggacatca  gtgtgtgtt  ctcccactg  caatcaaag  cttaaagac  1380
catgggtag  acgcctgga  tttaatcct  atcgctact  acaggataa  ccagcatca  1440
gggaaaagt  tgcctatgt  ccatttgga  ctgggcgtc  tcgttgtat  ggggaaaat  1500
ttgcctatg  tcaaattaa  acaatttgg  ccactatgc  tcgtttata  gaatttgat  1560
tcattgatg  atactttcc  actgtgaat  atacaacta  gattcacac  cctgagaac  1620
cagttatcc  ttacaaacg  agatcaaaa  gaaaaaggt  gcaaggaac  aatatatgt  1680
attatcact  taagccaca  aggcattcg  agagaatga  gtgtacaaa  caactcttg  1740
agtttactg  ttttttaag  gtgtaattc  aaaagccag  ttatgattt  ggattttgt  1800
aactgaatg  ttctatcaa  tataatagc  tttgacaca  tttctaata  ttatgatac  1860
tatacatgt  ctttcagga  gttccttgg  gaaacaatt  ttgaggggg  atctaggta  1920
ttggcagat  ctaaataat  taatttcca  atagtaatt  taagagtac  catcgctct  1980
gccaaataa  ttcagggta  tcaaatctt  gactagtcc  gcaaggtat  aagaataaa  2040
atcccagtg  gatacttgg  aaccacagt  tattattat  tatctgggc  attattgtg  2100
gtgtgagga  ggaagggta  ggaataatc  aacatctaa  gccttgaat  agagaatac  2160
aattgtttt  gtatgatga  actcagaaa  ggagatatt  taggaaaaa  aaatccttt  2220
gaattttaa  taaaatcac  gcatatggg  aattaagag  tccaggacc  tatttgata  2280
gagttccta  aaataatgt  attattaat  ctaaagact  ctcatgtat  ttgatctaa  2340
tactaaata  attacatat  tatttacct  ataaatatg  atctagttc  acaaggtca  2400
atttatgtg  aagtccaaa  tcaagtcct  aggggataa  tttgttttg  gctcagttg  2460
tccctgctt  ctttttttt  ttttttttt  tttgagatg  agtctcgct  tgttgccca  2520
gctggagtg  agtggtgcg  tctcagctc  ctgcatcct  tgcctcccg  gttcaagca  2580
ttctctgcc  cagcctccc  agtagttgg  attacaggc  cctgccacc  tgcctggct  2640
attttttgt  tttttagta  agacggggg  ttcactatg  tggctaggc  ggtcttgaa  2700
tcctgagcc  cgtgagtcc  cccgccttg  cctcccaaa  tgctgggat  acaggcatg  2760
gccaccgca  ctggccttc  ctgcttcct  tctagaatc  aattaggga  gtttgttac  2820
actcatatt  attaaaaca  ttaacaaac  tttttcttt  taaaatgtg  gatcagtga  2880
ctctggttt  aagataatc  gaaacaagg  ccttgggag  aataaaatt  gtcacattc  2940
gtaaagcac  ttctgttta  gaatcaact  atctcaaat  gtaactcgg  gcctaacta  3000
atgagatgg  tgaaaaaat  ccacatcgt  tgttttcac  aggtgatgc  aaaatattt  3060
gctttatgt  tattacagt  ctttttaaa  cactggaag  ctcatgtta  actctaatt  3120
tgaaggcag  atctctgct  atttttcag  ttaaaattc  ctttgaaaa  at  3172



<210> 101
<211> 503
<212> PRT
<213> Homo sapiens
<308> Q16850
<400> 101

Met Leu Leu Leu Gly Leu Leu Gln Ala Gly Gly Ser Val Leu Gly Gln 
  1               5                  10                  15
Ala Met Glu Lys Val Thr Gly Gly Asn Leu Leu Ser Met Leu Leu Ile 
             20                  25                  30
Ala Cys Ala Phe Thr Leu Ser Leu Val Tyr Leu Ile Arg Leu Ala Ala 
         35                  40                  45
Gly His Leu Val Gln Leu Pro Ala Gly Val Lys Ser Pro Pro Tyr Ile 
     50                  55                  60
Phe Ser Pro Ile Pro Phe Leu Gly His Ala Ile Ala Phe Gly Lys Ser 
 65                  70                  75                  80
Pro Ile Glu Phe Leu Glu Asn Ala Tyr Glu Lys Tyr Gly Pro Val Phe 
                 85                  90                  95
Ser Phe Thr Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp 
             100                105                110
Ala Ala Ala Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu 
         115                120                125
Asp Val Tyr Ser Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala 
     130                135                140
Tyr Asp Val Pro Asn Pro Val Phe Leu Glu Gln Lys Lys Met Leu Lys 
 145                150                155                160
Ser Gly Leu Asn Ile Ala His Phe Lys Gln His Val Ser Ile Ile Glu 
                 165                170                175
Lys Glu Thr Lys Glu Tyr Phe Glu Ser Trp Gly Glu Ser Gly Glu Lys 
             180                185                190
Asn Val Phe Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His 
         195                200                205
Cys Leu His Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala 
     210                215                220
Gln Leu Tyr Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu 
 225                230                235                240
Leu Pro Gly Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala 
                 245                250                255
His Arg Glu Ile Lys Asp Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg 
             260                265                270
Gln Ser Gln Glu Lys Ile Asp Asp Ile Leu Gln Thr Leu Leu Asp Ala 
         275                280                285
Thr Tyr Lys Asp Gly Arg Pro Leu Thr Asp Asp Glu Val Ala Gly Met 
     290                295                300
Leu Ile Gly Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser 
 305                310                315                320
Ala Trp Met Gly Phe Phe Leu Ala Arg Asp Lys Thr Leu Gln Lys Lys 
                 325                330                335
Cys Tyr Leu Glu Gln Lys Thr Val Cys Gly Glu Asn Leu Pro Pro Leu 
             340                345                350
Thr Tyr Asp Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys 
         355                360                365
Glu Thr Leu Arg Leu Arg Pro Pro Ile Met Ile Met Met Arg Met Ala 
     370                375                380
Arg Thr Pro Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln 
 385                390                395                400
Val Cys Val Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val 
                 405                410                415
Glu Arg Leu Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala 
             420                425                430
Ser Gly Glu Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg 
         435                440                445
Cys Ile Gly Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser 
     450                455                460
Thr Met Leu Arg Leu Tyr Glu Phe Asp Leu Ile Asp Gly Tyr Phe Pro 
 465                470                475                480
Thr Val Asn Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile 
                 485                490                495
Arg Tyr Lys Arg Arg Ser Lys 
             500



<210> 102
<211> 2015
<212> DNA
<213> Rattus norvegicus
<308> AB004096
<400> 102

gtgagagtt  ctttatacg  tacacattc  tcctctaag  cgagaccac  ccaggctga  60
agtagtgaa  attttaaaa  ttactctga  gaaaacttt  tttttaaaa  agggcgcca  120
cgttgtatt  gagaaaatt  tgcctatgt  caaattaag  caatttggt  cactatgct  180
cgtttatat  aatttgacc  catcaatgg  tattttccc  gtgtgaatt  tacaacaat  240
attcatacc  cagaaaacc  agtaatccg  tacaaacga  gatcaaaat  aagaaagga  300
caaggagcc  gtgtggaga  gggactgca  gctgcagct  ggcagagaa  gaagctttg  360
cacagcttt  atactgtac  gttttttaa  tgtgtggtt  tgaaagcca  tttgatttt  420
atgttttat  aactcggtg  tttttgtca  acctaatgg  atttgaaac  gttataata  480
ttctgatag  atttcaggg  agccaagtt  atgttagaa  tcgtttagg  gagcctcgg  540
attcagaga  gatacagaa  atagcatcc  ggtaactaa  ttcagaagc  cacgttgcc  600
tagggagat  ccggcttgg  actagtttg  gaagtttta  gcctggtca  atgctacag  660
ggcaatggg  cattggtgt  gttgggcca  ttctgtgcg  aaagatgtg  gagggtgaa  720
gataagttt  ctgcgaagc  ctagatggt  tgagtgccc  ttgtagtgt  aactgagag  780
accactcca  cgagatggc  gcaatcttg  accttatct  gataacctt  tttcctaaa  840
ataataaat  ctaaagagt  cttatgtta  tggttccag  aaaatccaa  atcaaatcc  900
tgtggaatt  ttaatttta  ttaaaaaaa  aaaaaaaca  gtaccatga  tttaaaagt  960
tatgattct  agcttagtg  attctggcc  tgagattga  gaatgggga  atggtatca  1020
tgcccgtgt  ctttggagg  tgtgctcag  agccaacct  acagattgt  accatgggc  1080
taattctga  ctgcccata  tctgtatta  gaatcaaga  atctgttgc  gggtgtggt  1140
ctgcacacc  gtaatacta  tgctcgggc  gaggcagaa  gattgagag  ttgaggcca  1200
cctagagct  catagcaag  cttaacacc  tccccaaaa  aaaaccttt  ttctctaaa  1260
tatgtgtac  ggctggtct  aggtgacaa  ctgacacac  ctagggtca  cagagaaaa  1320
ggaacctca  ttgaggaaa  gctgtaagg  tgcttagtg  tcaatgaga  agggcccag  1380
ccactgtgg  tggttccac  cctaggctg  tcatcctgg  tcctaagaa  gcaggctga  1440
taagacacc  ggagcaaga  agtaagcag  atccttcat  gcctctgca  cagctcctg  1500
cttaggttc  tgacccgct  gagttcccg  cctgacttt  tttgataat  aacagtagt  1560
tggaagtgt  agccaaata  cccaccccc  ccctcccaa  ttgcttttt  ctcatggtg  1620
tttgtagca  tagaaaccc  aactgttac  gctgtaaga  gcttttgaa  actcttcaa  1680
tgaaggccc  aatctctgc  gttaaaggt  tcagattaa  attctctat  agaaaagtt  1740
tgctggtct  tattcatgg  tttgaagct  tgcttcagt  agtacagtt  aagaggtct  1800
ggaatgggg  tggggattt  gctcagtgg  agagcgctt  cctaggaag  gcaaggccc  1860
gggttcggt  cccagctcc  aaaaaaaga  caaaaaaaa  agaggtctg  gaattcaga  1920
acttagatc  tatttgcct  aaatcggct  ccttcagta  tacctttag  tatttagat  1980
agtcactct  gtgatccgt  gacctgcag  tcgac  2015



<210> 103
<211> 503
<212> PRT
<213> Rattus norvegicus
<308> BAA20354
<400> 103

Met Val Leu Leu Gly Leu Leu Gln Ser Gly Gly Ser Val Leu Gly Gln 
  1               5                  10                  15
Ala Met Glu Gln Val Thr Gly Gly Asn Leu Leu Ser Thr Leu Leu Ile 
             20                  25                  30
Ala Cys Ala Phe Thr Leu Ser Leu Val Tyr Leu Phe Arg Leu Ala Val 
         35                  40                  45
Gly His Met Val Gln Leu Pro Ala Gly Ala Lys Ser Pro Pro Tyr Ile 
     50                  55                  60
Tyr Ser Pro Ile Pro Phe Leu Gly His Ala Ile Ala Phe Gly Lys Ser 
 65                  70                  75                  80
Pro Ile Glu Phe Leu Glu Asn Ala Tyr Glu Lys Tyr Gly Pro Val Phe 
                 85                  90                  95
Ser Phe Thr Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp 
             100                105                110
Ala Ala Ala Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu 
         115                120                125
Glu Val Tyr Gly Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala 
     130                135                140
Tyr Asp Val Pro Asn Ala Val Phe Leu Glu Gln Lys Lys Ile Leu Lys 
 145                150                155                160
Ser Gly Leu Asn Ile Ala His Phe Lys Gln Tyr Val Ser Ile Ile Glu 
                 165                170                175
Lys Glu Ala Lys Glu Tyr Phe Lys Ser Trp Gly Glu Ser Gly Glu Arg 
             180                185                190
Asn Val Phe Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His 
         195                200                205
Cys Leu His Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala 
     210                215                220
Gln Leu Tyr Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu 
 225                230                235                240
Leu Pro Gly Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala 
                 245                250                255
His Arg Glu Ile Lys Asn Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg 
             260                265                270
Leu Ser Lys Glu Pro Ala Glu Asp Ile Leu Gln Thr Leu Leu Asp Ser 
         275                280                285
Thr Tyr Lys Asp Gly Arg Pro Leu Thr Asp Asp Glu Ile Ala Gly Met 
     290                295                300
Leu Ile Gly Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser 
 305                310                315                320
Ala Trp Met Gly Phe Phe Leu Ala Arg Asp Lys Pro Leu Gln Asp Lys 
                 325                330                335
Cys Tyr Leu Glu Gln Lys Thr Val Cys Gly Glu Asp Leu Pro Pro Leu 
             340                345                350
Thr Tyr Glu Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys 
         355                360                365
Glu Thr Leu Arg Leu Arg Pro Pro Ile Met Thr Met Met Arg Met Ala 
     370                375                380
Lys Thr Pro Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln 
 385                390                395                400
Val Cys Val Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val 
                 405                410                415
Glu Arg Leu Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala 
             420                425                430
Ser Gly Glu Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg 
         435                440                445
Cys Ile Gly Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser 
     450                455                460
Thr Met Leu Arg Leu Tyr Glu Phe Asp Leu Ile Asn Gly Tyr Phe Pro 
 465                470                475                480
Ser Val Asn Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile 
                 485                490                495
Arg Tyr Lys Arg Arg Ser Lys 
             500



<210> 104
<211> 3172
<212> DNA
<213> Homo sapiens
<308> U23942
<400> 104

gctgggttt  gtaggagac  tggggcaag  ccccctgtg  acgaccatc  gccagcttc  60
ctcgttccg  cgattggga  gagcggtgg  gacctcggc  ttcagtgtt  ccgacggag  120
gaatggcgg  ggcggctgg  atgctgctg  tgggcttgc  gcaggcggg  gggtcggtg  180
tgggccagg  gatggagaa  gtgacaggc  gcaacctct  gtccatgct  ctgatcgcc  240
gcgccttca  cctcagcct  gtctacctg  tccgtctgg  cgccggcca  ctggtccag  300
tgcccgcag  ggtgaaaag  cctccatac  ttttctccc  aattccatt  cttgggcat  360
ccatagcat  tgggaaaag  ccaattgaa  ttctagaaa  tgcatatga  aagtatgga  420
ctgtattta  ttttaccat  gtaggcaag  catttactt  ccttctggg  agtgatgct  480
ctgcactgc  ttttaatag  aaaaatgaa  acctgaatg  agaagatgt  tacagtcgc  540
tgacaacac  tgtgtttgg  aagggagtt  catacgatg  gcctaatcc  gttttcttg  600
agcagaaga  aatgttaaa  agtggcctt  acatagccc  ctttaaaca  catgtttct  660
taattgaaa  agaaacaaa  gaatacttt  agagttggg  agaaagtgg  gaaaaaaat  720
tgtttgaag  tctttctga  ctcataatt  taacagcta  ccattgttt  catggaaag  780
aaatcagaa  tcaactcaa  gaaaaggta  cacagctgt  tgcagattt  gatggaggt  840
tcagccatg  agcctggct  ttaccaggt  ggctgcctt  gcctagttt  agacgcagg  900
acagagctc  tcgggaaat  aaggatatt  tctataagg  aatccagaa  cgcagacag  960
ctcaagaaa  aattgatga  attctccaa  ctttactag  tgctacata  aaggatggg  1020
gtcctttga  tgatgatga  gtagcaggg  tgcttattg  attactctt  gcagggcag  1080
atacatcct  aactactag  gcttggatg  gcttctttt  ggccagaga  aaaacactt  1140
aaaaaaaat  ttatttaga  cagaaaaca  tctgtggag  gaatctgcc  cctttaact  1200
atgaccagc  caaggatct  aatttactt  atcgctgta  aaaagaaac  ttaagactt  1260
gacctccta  aatgatcat  atgagaatg  ccagaactc  tcagactgt  gcagggtat  1320
ccattcctc  aggacatca  gtgtgtgtt  ctcccactg  caatcaaag  cttaaagac  1380
catgggtag  acgcctgga  tttaatcct  atcgctact  acaggataa  ccagcatca  1440
gggaaaagt  tgcctatgt  ccatttgga  ctgggcgtc  tcgttgtat  ggggaaaat  1500
ttgcctatg  tcaaattaa  acaatttgg  ccactatgc  tcgtttata  gaatttgat  1560
tcattgatg  atactttcc  actgtgaat  atacaacta  gattcacac  cctgagaac  1620
cagttatcc  ttacaaacg  agatcaaaa  gaaaaaggt  gcaaggaac  aatatatgt  1680
attatcact  taagccaca  aggcattcg  agagaatga  gtgtacaaa  caactcttg  1740
agtttactg  ttttttaag  gtgtaattc  aaaagccag  ttatgattt  ggattttgt  1800
aactgaatg  ttctatcaa  tataatagc  tttgacaca  tttctaata  ttatgatac  1860
tatacatgt  ctttcagga  gttccttgg  gaaacaatt  ttgaggggg  atctaggta  1920
ttggcagat  ctaaataat  taatttcca  atagtaatt  taagagtac  catcgctct  1980
gccaaataa  ttcagggta  tcaaatctt  gactagtcc  gcaaggtat  aagaataaa  2040
atcccagtg  gatacttgg  aaccacagt  tattattat  tatctgggc  attattgtg  2100
gtgtgagga  ggaagggta  ggaataatc  aacatctaa  gccttgaat  agagaatac  2160
aattgtttt  gtatgatga  actcagaaa  ggagatatt  taggaaaaa  aaatccttt  2220
gaattttaa  taaaatcac  gcatatggg  aattaagag  tccaggacc  tatttgata  2280
gagttccta  aaataatgt  attattaat  ctaaagact  ctcatgtat  ttgatctaa  2340
tactaaata  attacatat  tatttacct  ataaatatg  atctagttc  acaaggtca  2400
atttatgtg  aagtccaaa  tcaagtcct  aggggataa  tttgttttg  gctcagttg  2460
tccctgctt  ctttttttt  ttttttttt  tttgagatg  agtctcgct  tgttgccca  2520
gctggagtg  agtggtgcg  tctcagctc  ctgcatcct  tgcctcccg  gttcaagca  2580
ttctctgcc  cagcctccc  agtagttgg  attacaggc  cctgccacc  tgcctggct  2640
attttttgt  tttttagta  agacggggg  ttcactatg  tggctaggc  ggtcttgaa  2700
tcctgagcc  cgtgagtcc  cccgccttg  cctcccaaa  tgctgggat  acaggcatg  2760
gccaccgca  ctggccttc  ctgcttcct  tctagaatc  aattaggga  gtttgttac  2820
actcatatt  attaaaaca  ttaacaaac  tttttcttt  taaaatgtg  gatcagtga  2880
ctctggttt  aagataatc  gaaacaagg  ccttgggag  aataaaatt  gtcacattc  2940
gtaaagcac  ttctgttta  gaatcaact  atctcaaat  gtaactcgg  gcctaacta  3000
atgagatgg  tgaaaaaat  ccacatcgt  tgttttcac  aggtgatgc  aaaatattt  3060
gctttatgt  tattacagt  ctttttaaa  cactggaag  ctcatgtta  actctaatt  3120
tgaaggcag  atctctgct  atttttcag  ttaaaattc  ctttgaaaa  at  3172



<210> 105
<211> 503
<212> PRT
<213> Homo sapiens
<308> Q16850
<400> 105

Met Leu Leu Leu Gly Leu Leu Gln Ala Gly Gly Ser Val Leu Gly Gln 
  1               5                  10                  15
Ala Met Glu Lys Val Thr Gly Gly Asn Leu Leu Ser Met Leu Leu Ile 
             20                  25                  30
Ala Cys Ala Phe Thr Leu Ser Leu Val Tyr Leu Ile Arg Leu Ala Ala 
         35                  40                  45
Gly His Leu Val Gln Leu Pro Ala Gly Val Lys Ser Pro Pro Tyr Ile 
     50                  55                  60
Phe Ser Pro Ile Pro Phe Leu Gly His Ala Ile Ala Phe Gly Lys Ser 
 65                  70                  75                  80
Pro Ile Glu Phe Leu Glu Asn Ala Tyr Glu Lys Tyr Gly Pro Val Phe 
                 85                  90                  95
Ser Phe Thr Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp 
             100                105                110
Ala Ala Ala Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu 
         115                120                125
Asp Val Tyr Ser Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala 
     130                135                140
Tyr Asp Val Pro Asn Pro Val Phe Leu Glu Gln Lys Lys Met Leu Lys 
 145                150                155                160
Ser Gly Leu Asn Ile Ala His Phe Lys Gln His Val Ser Ile Ile Glu 
                 165                170                175
Lys Glu Thr Lys Glu Tyr Phe Glu Ser Trp Gly Glu Ser Gly Glu Lys 
             180                185                190
Asn Val Phe Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His 
         195                200                205
Cys Leu His Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala 
     210                215                220
Gln Leu Tyr Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu 
 225                230                235                240
Leu Pro Gly Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala 
                 245                250                255
His Arg Glu Ile Lys Asp Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg 
             260                265                270
Gln Ser Gln Glu Lys Ile Asp Asp Ile Leu Gln Thr Leu Leu Asp Ala 
         275                280                285
Thr Tyr Lys Asp Gly Arg Pro Leu Thr Asp Asp Glu Val Ala Gly Met 
     290                295                300
Leu Ile Gly Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser 
 305                310                315                320
Ala Trp Met Gly Phe Phe Leu Ala Arg Asp Lys Thr Leu Gln Lys Lys 
                 325                330                335
Cys Tyr Leu Glu Gln Lys Thr Val Cys Gly Glu Asn Leu Pro Pro Leu 
             340                345                350
Thr Tyr Asp Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys 
         355                360                365
Glu Thr Leu Arg Leu Arg Pro Pro Ile Met Ile Met Met Arg Met Ala 
     370                375                380
Arg Thr Pro Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln 
 385                390                395                400
Val Cys Val Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val 
                 405                410                415
Glu Arg Leu Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala 
             420                425                430
Ser Gly Glu Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg 
         435                440                445
Cys Ile Gly Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser 
     450                455                460
Thr Met Leu Arg Leu Tyr Glu Phe Asp Leu Ile Asp Gly Tyr Phe Pro 
 465                470                475                480
Thr Val Asn Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile 
                 485                490                495
Arg Tyr Lys Arg Arg Ser Lys 
             500



<210> 106
<211> 2015
<212> DNA
<213> Rattus norvegicus
<308> AB004096
<400> 106

gtgagagtt  ctttatacg  tacacattc  tcctctaag  cgagaccac  ccaggctga  60
agtagtgaa  attttaaaa  ttactctga  gaaaacttt  tttttaaaa  agggcgcca  120
cgttgtatt  gagaaaatt  tgcctatgt  caaattaag  caatttggt  cactatgct  180
cgtttatat  aatttgacc  catcaatgg  tattttccc  gtgtgaatt  tacaacaat  240
attcatacc  cagaaaacc  agtaatccg  tacaaacga  gatcaaaat  aagaaagga  300
caaggagcc  gtgtggaga  gggactgca  gctgcagct  ggcagagaa  gaagctttg  360
cacagcttt  atactgtac  gttttttaa  tgtgtggtt  tgaaagcca  tttgatttt  420
atgttttat  aactcggtg  tttttgtca  acctaatgg  atttgaaac  gttataata  480
ttctgatag  atttcaggg  agccaagtt  atgttagaa  tcgtttagg  gagcctcgg  540
attcagaga  gatacagaa  atagcatcc  ggtaactaa  ttcagaagc  cacgttgcc  600
tagggagat  ccggcttgg  actagtttg  gaagtttta  gcctggtca  atgctacag  660
ggcaatggg  cattggtgt  gttgggcca  ttctgtgcg  aaagatgtg  gagggtgaa  720
gataagttt  ctgcgaagc  ctagatggt  tgagtgccc  ttgtagtgt  aactgagag  780
accactcca  cgagatggc  gcaatcttg  accttatct  gataacctt  tttcctaaa  840
ataataaat  ctaaagagt  cttatgtta  tggttccag  aaaatccaa  atcaaatcc  900
tgtggaatt  ttaatttta  ttaaaaaaa  aaaaaaaca  gtaccatga  tttaaaagt  960
tatgattct  agcttagtg  attctggcc  tgagattga  gaatgggga  atggtatca  1020
tgcccgtgt  ctttggagg  tgtgctcag  agccaacct  acagattgt  accatgggc  1080
taattctga  ctgcccata  tctgtatta  gaatcaaga  atctgttgc  gggtgtggt  1140
ctgcacacc  gtaatacta  tgctcgggc  gaggcagaa  gattgagag  ttgaggcca  1200
cctagagct  catagcaag  cttaacacc  tccccaaaa  aaaaccttt  ttctctaaa  1260
tatgtgtac  ggctggtct  aggtgacaa  ctgacacac  ctagggtca  cagagaaaa  1320
ggaacctca  ttgaggaaa  gctgtaagg  tgcttagtg  tcaatgaga  agggcccag  1380
ccactgtgg  tggttccac  cctaggctg  tcatcctgg  tcctaagaa  gcaggctga  1440
taagacacc  ggagcaaga  agtaagcag  atccttcat  gcctctgca  cagctcctg  1500
cttaggttc  tgacccgct  gagttcccg  cctgacttt  tttgataat  aacagtagt  1560
tggaagtgt  agccaaata  cccaccccc  ccctcccaa  ttgcttttt  ctcatggtg  1620
tttgtagca  tagaaaccc  aactgttac  gctgtaaga  gcttttgaa  actcttcaa  1680
tgaaggccc  aatctctgc  gttaaaggt  tcagattaa  attctctat  agaaaagtt  1740
tgctggtct  tattcatgg  tttgaagct  tgcttcagt  agtacagtt  aagaggtct  1800
ggaatgggg  tggggattt  gctcagtgg  agagcgctt  cctaggaag  gcaaggccc  1860
gggttcggt  cccagctcc  aaaaaaaga  caaaaaaaa  agaggtctg  gaattcaga  1920
acttagatc  tatttgcct  aaatcggct  ccttcagta  tacctttag  tatttagat  1980
agtcactct  gtgatccgt  gacctgcag  tcgac  2015



<210> 107
<211> 503
<212> PRT
<213> Rattus norvegicus
<308> BAA20354
<400> 107

Met Val Leu Leu Gly Leu Leu Gln Ser Gly Gly Ser Val Leu Gly Gln 
  1               5                  10                  15
Ala Met Glu Gln Val Thr Gly Gly Asn Leu Leu Ser Thr Leu Leu Ile 
             20                  25                  30
Ala Cys Ala Phe Thr Leu Ser Leu Val Tyr Leu Phe Arg Leu Ala Val 
         35                  40                  45
Gly His Met Val Gln Leu Pro Ala Gly Ala Lys Ser Pro Pro Tyr Ile 
     50                  55                  60
Tyr Ser Pro Ile Pro Phe Leu Gly His Ala Ile Ala Phe Gly Lys Ser 
 65                  70                  75                  80
Pro Ile Glu Phe Leu Glu Asn Ala Tyr Glu Lys Tyr Gly Pro Val Phe 
                 85                  90                  95
Ser Phe Thr Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp 
             100                105                110
Ala Ala Ala Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu 
         115                120                125
Glu Val Tyr Gly Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala 
     130                135                140
Tyr Asp Val Pro Asn Ala Val Phe Leu Glu Gln Lys Lys Ile Leu Lys 
 145                150                155                160
Ser Gly Leu Asn Ile Ala His Phe Lys Gln Tyr Val Ser Ile Ile Glu 
                 165                170                175
Lys Glu Ala Lys Glu Tyr Phe Lys Ser Trp Gly Glu Ser Gly Glu Arg 
             180                185                190
Asn Val Phe Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His 
         195                200                205
Cys Leu His Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala 
     210                215                220
Gln Leu Tyr Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu 
 225                230                235                240
Leu Pro Gly Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala 
                 245                250                255
His Arg Glu Ile Lys Asn Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg 
             260                265                270
Leu Ser Lys Glu Pro Ala Glu Asp Ile Leu Gln Thr Leu Leu Asp Ser 
         275                280                285
Thr Tyr Lys Asp Gly Arg Pro Leu Thr Asp Asp Glu Ile Ala Gly Met 
     290                295                300
Leu Ile Gly Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser 
 305                310                315                320
Ala Trp Met Gly Phe Phe Leu Ala Arg Asp Lys Pro Leu Gln Asp Lys 
                 325                330                335
Cys Tyr Leu Glu Gln Lys Thr Val Cys Gly Glu Asp Leu Pro Pro Leu 
             340                345                350
Thr Tyr Glu Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys 
         355                360                365
Glu Thr Leu Arg Leu Arg Pro Pro Ile Met Thr Met Met Arg Met Ala 
     370                375                380
Lys Thr Pro Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln 
 385                390                395                400
Val Cys Val Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val 
                 405                410                415
Glu Arg Leu Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala 
             420                425                430
Ser Gly Glu Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg 
         435                440                445
Cys Ile Gly Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser 
     450                455                460
Thr Met Leu Arg Leu Tyr Glu Phe Asp Leu Ile Asn Gly Tyr Phe Pro 
 465                470                475                480
Ser Val Asn Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile 
                 485                490                495
Arg Tyr Lys Arg Arg Ser Lys 
             500



<210> 108
<211> 3172
<212> DNA
<213> Homo sapiens
<308> U23942
<400> 108

gctgggttt  gtaggagac  tggggcaag  ccccctgtg  acgaccatc  gccagcttc  60
ctcgttccg  cgattggga  gagcggtgg  gacctcggc  ttcagtgtt  ccgacggag  120
gaatggcgg  ggcggctgg  atgctgctg  tgggcttgc  gcaggcggg  gggtcggtg  180
tgggccagg  gatggagaa  gtgacaggc  gcaacctct  gtccatgct  ctgatcgcc  240
gcgccttca  cctcagcct  gtctacctg  tccgtctgg  cgccggcca  ctggtccag  300
tgcccgcag  ggtgaaaag  cctccatac  ttttctccc  aattccatt  cttgggcat  360
ccatagcat  tgggaaaag  ccaattgaa  ttctagaaa  tgcatatga  aagtatgga  420
ctgtattta  ttttaccat  gtaggcaag  catttactt  ccttctggg  agtgatgct  480
ctgcactgc  ttttaatag  aaaaatgaa  acctgaatg  agaagatgt  tacagtcgc  540
tgacaacac  tgtgtttgg  aagggagtt  catacgatg  gcctaatcc  gttttcttg  600
agcagaaga  aatgttaaa  agtggcctt  acatagccc  ctttaaaca  catgtttct  660
taattgaaa  agaaacaaa  gaatacttt  agagttggg  agaaagtgg  gaaaaaaat  720
tgtttgaag  tctttctga  ctcataatt  taacagcta  ccattgttt  catggaaag  780
aaatcagaa  tcaactcaa  gaaaaggta  cacagctgt  tgcagattt  gatggaggt  840
tcagccatg  agcctggct  ttaccaggt  ggctgcctt  gcctagttt  agacgcagg  900
acagagctc  tcgggaaat  aaggatatt  tctataagg  aatccagaa  cgcagacag  960
ctcaagaaa  aattgatga  attctccaa  ctttactag  tgctacata  aaggatggg  1020
gtcctttga  tgatgatga  gtagcaggg  tgcttattg  attactctt  gcagggcag  1080
atacatcct  aactactag  gcttggatg  gcttctttt  ggccagaga  aaaacactt  1140
aaaaaaaat  ttatttaga  cagaaaaca  tctgtggag  gaatctgcc  cctttaact  1200
atgaccagc  caaggatct  aatttactt  atcgctgta  aaaagaaac  ttaagactt  1260
gacctccta  aatgatcat  atgagaatg  ccagaactc  tcagactgt  gcagggtat  1320
ccattcctc  aggacatca  gtgtgtgtt  ctcccactg  caatcaaag  cttaaagac  1380
catgggtag  acgcctgga  tttaatcct  atcgctact  acaggataa  ccagcatca  1440
gggaaaagt  tgcctatgt  ccatttgga  ctgggcgtc  tcgttgtat  ggggaaaat  1500
ttgcctatg  tcaaattaa  acaatttgg  ccactatgc  tcgtttata  gaatttgat  1560
tcattgatg  atactttcc  actgtgaat  atacaacta  gattcacac  cctgagaac  1620
cagttatcc  ttacaaacg  agatcaaaa  gaaaaaggt  gcaaggaac  aatatatgt  1680
attatcact  taagccaca  aggcattcg  agagaatga  gtgtacaaa  caactcttg  1740
agtttactg  ttttttaag  gtgtaattc  aaaagccag  ttatgattt  ggattttgt  1800
aactgaatg  ttctatcaa  tataatagc  tttgacaca  tttctaata  ttatgatac  1860
tatacatgt  ctttcagga  gttccttgg  gaaacaatt  ttgaggggg  atctaggta  1920
ttggcagat  ctaaataat  taatttcca  atagtaatt  taagagtac  catcgctct  1980
gccaaataa  ttcagggta  tcaaatctt  gactagtcc  gcaaggtat  aagaataaa  2040
atcccagtg  gatacttgg  aaccacagt  tattattat  tatctgggc  attattgtg  2100
gtgtgagga  ggaagggta  ggaataatc  aacatctaa  gccttgaat  agagaatac  2160
aattgtttt  gtatgatga  actcagaaa  ggagatatt  taggaaaaa  aaatccttt  2220
gaattttaa  taaaatcac  gcatatggg  aattaagag  tccaggacc  tatttgata  2280
gagttccta  aaataatgt  attattaat  ctaaagact  ctcatgtat  ttgatctaa  2340
tactaaata  attacatat  tatttacct  ataaatatg  atctagttc  acaaggtca  2400
atttatgtg  aagtccaaa  tcaagtcct  aggggataa  tttgttttg  gctcagttg  2460
tccctgctt  ctttttttt  ttttttttt  tttgagatg  agtctcgct  tgttgccca  2520
gctggagtg  agtggtgcg  tctcagctc  ctgcatcct  tgcctcccg  gttcaagca  2580
ttctctgcc  cagcctccc  agtagttgg  attacaggc  cctgccacc  tgcctggct  2640
attttttgt  tttttagta  agacggggg  ttcactatg  tggctaggc  ggtcttgaa  2700
tcctgagcc  cgtgagtcc  cccgccttg  cctcccaaa  tgctgggat  acaggcatg  2760
gccaccgca  ctggccttc  ctgcttcct  tctagaatc  aattaggga  gtttgttac  2820
actcatatt  attaaaaca  ttaacaaac  tttttcttt  taaaatgtg  gatcagtga  2880
ctctggttt  aagataatc  gaaacaagg  ccttgggag  aataaaatt  gtcacattc  2940
gtaaagcac  ttctgttta  gaatcaact  atctcaaat  gtaactcgg  gcctaacta  3000
atgagatgg  tgaaaaaat  ccacatcgt  tgttttcac  aggtgatgc  aaaatattt  3060
gctttatgt  tattacagt  ctttttaaa  cactggaag  ctcatgtta  actctaatt  3120
tgaaggcag  atctctgct  atttttcag  ttaaaattc  ctttgaaaa  at  3172



<210> 109
<211> 503
<212> PRT
<213> Homo sapiens
<308> Q16850
<400> 109

Met Leu Leu Leu Gly Leu Leu Gln Ala Gly Gly Ser Val Leu Gly Gln 
  1               5                  10                  15
Ala Met Glu Lys Val Thr Gly Gly Asn Leu Leu Ser Met Leu Leu Ile 
             20                  25                  30
Ala Cys Ala Phe Thr Leu Ser Leu Val Tyr Leu Ile Arg Leu Ala Ala 
         35                  40                  45
Gly His Leu Val Gln Leu Pro Ala Gly Val Lys Ser Pro Pro Tyr Ile 
     50                  55                  60
Phe Ser Pro Ile Pro Phe Leu Gly His Ala Ile Ala Phe Gly Lys Ser 
 65                  70                  75                  80
Pro Ile Glu Phe Leu Glu Asn Ala Tyr Glu Lys Tyr Gly Pro Val Phe 
                 85                  90                  95
Ser Phe Thr Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp 
             100                105                110
Ala Ala Ala Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu 
         115                120                125
Asp Val Tyr Ser Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala 
     130                135                140
Tyr Asp Val Pro Asn Pro Val Phe Leu Glu Gln Lys Lys Met Leu Lys 
 145                150                155                160
Ser Gly Leu Asn Ile Ala His Phe Lys Gln His Val Ser Ile Ile Glu 
                 165                170                175
Lys Glu Thr Lys Glu Tyr Phe Glu Ser Trp Gly Glu Ser Gly Glu Lys 
             180                185                190
Asn Val Phe Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His 
         195                200                205
Cys Leu His Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala 
     210                215                220
Gln Leu Tyr Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu 
 225                230                235                240
Leu Pro Gly Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala 
                 245                250                255
His Arg Glu Ile Lys Asp Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg 
             260                265                270
Gln Ser Gln Glu Lys Ile Asp Asp Ile Leu Gln Thr Leu Leu Asp Ala 
         275                280                285
Thr Tyr Lys Asp Gly Arg Pro Leu Thr Asp Asp Glu Val Ala Gly Met 
     290                295                300
Leu Ile Gly Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser 
 305                310                315                320
Ala Trp Met Gly Phe Phe Leu Ala Arg Asp Lys Thr Leu Gln Lys Lys 
                 325                330                335
Cys Tyr Leu Glu Gln Lys Thr Val Cys Gly Glu Asn Leu Pro Pro Leu 
             340                345                350
Thr Tyr Asp Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys 
         355                360                365
Glu Thr Leu Arg Leu Arg Pro Pro Ile Met Ile Met Met Arg Met Ala 
     370                375                380
Arg Thr Pro Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln 
 385                390                395                400
Val Cys Val Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val 
                 405                410                415
Glu Arg Leu Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala 
             420                425                430
Ser Gly Glu Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg 
         435                440                445
Cys Ile Gly Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser 
     450                455                460
Thr Met Leu Arg Leu Tyr Glu Phe Asp Leu Ile Asp Gly Tyr Phe Pro 
 465                470                475                480
Thr Val Asn Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile 
                 485                490                495
Arg Tyr Lys Arg Arg Ser Lys 
             500



<210> 110
<211> 3373
<212> DNA
<213> Rattus norvegicus
<308> AB004276
<400> 110

agtccaacg  cggaactgc  gagaaattc  gtccctccg  gtatggctc  ccagctttc  60
gtaagatta  catttccat  atcacaagc  aaggtaatc  aggcacctg  gcccggtga  120
gactgagag  attcttttg  caataaaca  tgactgctt  ccagaatca  caccgtcat  180
gccggctgg  gctgttctg  acgctgatg  ggacgctgt  caagatcgg  gtaggtcag  240
ttcgctact  ggtgccaga  gagacagat  aaggcactg  tgtaggaaa  atctccaag  300
acctggggc  ggagccccg  gagctggcg  agcgagggg  ccgcatcgt  tctagaggt  360
ggtcgcagc  tttctccca  gaatccgcg  ggcgcaact  ggtcaccgc  agcaggata  420
accgggagg  gctgtgcgc  cagagtatt  cctgtcttg  aaatattaa  atcctagtt  480
aggagaaag  gaaactctt  ggagtagaa  taactgata  taacgataa  aatccgaag  540
tccatgttg  ggatctgga  gtgaaaatt  acgaaatcg  tgcccctgg  gcacggtat  600
cacttccaa  agctgttga  ccagatgtg  gcataaact  cctccagag  taccagctc  660
gccccaacc  gcacttctc  ctggacatt  agaggggag  cgacggaac  ataaaccca  720
agctggtgc  ggagaacac  ctggaccga  aggaagagc  ctctcacca  ctgatcctc  780
ccgcctccg  tgccgaacg  cgccgctcc  gcacagcgc  catccaggt  acagtgttg  840
ataccaacg  caatgcccc  gttttcgac  aaccggttt  ccgcgtgaa  gtcctcgag  900
acgtgaccc  aggcactct  ctgctcaca  tgagagcta  cgacccgga  gagggtgcc  960
acggaaaag  gacatataa  ttccaaaaa  tcaatgaca  acaatcgct  ctattccat  1020
ttcatgaaa  cacggggga  atgacagta  caaagaatc  ggactatga  gaatgctca  1080
tgtatgaaa  ggaaataca  gctgaagat  tgggggcgc  tctggggag  agcaaagtg  1140
taattatgg  agaagatgt  aatgacaat  ggccagaag  gaccattac  tccttgttt  1200
acccggtat  ggaaaattc  cttcccggg  cagtaattg  cttcttgaa  gtgcatgac  1260
gagactctg  aaagaacgg  caagttgtc  gttacacgc  tgataactt  ccttttaaa  1320
tagaaaagt  aatagataa  tattataga  tggtgacat  gaaatattt  gaccgagaa  1380
aagtctcca  ctacaatat  acagtgata  cctcagatc  aggagccca  tctgtcact  1440
aaacttaca  tgccctgat  gtggcagac  ctaatgaca  ccctcctcg  tttcctcac  1500
cctcctaca  agcctatat  ccagagaac  acctgaggg  cgcctccat  ttctcactg  1560
ctgcacatg  tcctgacag  caggaaaat  cacaggtca  ttactctgt  tctgaggac  1620
ccatacagg  agtgccttt  tcctcttat  tctccatca  ctcagatac  ggtgtcctg  1680
atgcactgc  ctcttttga  ttcgagaag  tacaagact  gcagctact  gttgttgcc  1740
ctgacagtg  aagcccacc  ctcagcagc  atgtgtcat  gagcttgtt  gtgttggac  1800
agaacgaca  cgcacctga  attctatat  ctagcttcc  cacagatgg  tccactggt  1860
tggaactag  accccgctc  gcagagcct  gatacctag  gaccaaagt  gtggcagtg  1920
acaaagact  aggacagaa  gcttggctg  cctaccgtc  gctgaaggc  agcgaacct  1980
ggctcttct  tgtaggact  cacacgggt  aggtgcgta  agcgagggc  ctgctggac  2040
gagatgctc  caaacagaa  ctggtgatg  ccgtgcagg  ccatggcca  ccccctctc  2100
cggccactg  aactctcac  gtggcagtg  ctaacagca  ccctgaggt  ttggctgac  2160
tgagcagca  taggacccc  ggggtacca  aggattctg  tatcacgct  cacctggtg  2220
tggcagtgg  tgtggtctc  tgtgtcttc  ttgtctttg  cattgtcct  ctagctctc  2280
ggcttcagc  ctggcagaa  tctcgccag  tccagggct  caaaggtgg  ttggctcct  2340
cacctccat  acattttgt  ggcatcgac  gggtacagg  ttttctaca  acctattct  2400
atgaagtct  gctcacttc  ggctcccag  caagccaca  tatctttcc  cagcccaac  2460
atgcagaca  gctcattaa  caagaaggc  gtgagaaaa  tgattcctt  ttaacatcc  2520
tagattttc  tgagagtaa  cgtgaagat  cttgcgccc  gcaagcccc  cccaacact  2580
actggcgtt  ctctcaagc  cagagaccc  gcacgagcg  atcccaaaa  ggggatgaa  2640
ccggcacct  gcccaacaa  cagttcgat  cagagatgc  gcaagccat  atcttggcc  2700
ctgccagtg  agccgctga  gggagctcc  ctctgggag  gggcactgg  actatgggt  2760
tgagcgctc  atatggacc  cagtttacc  tgcagcacg  gcctgacta  cgccagaac  2820
tgtacatcc  tggcagcaa  gccacactg  ccaacgcag  tggcaaacg  gatggcaag  2880
ctccggcag  cggcaatgg  aacaacaac  agtcgggca  gaaagagaa  aagtaatat  2940
gaggccagg  cttgagcca  agggcagcc  ccctcccca  ccagtccag  ttgtcctta  3000
ttgtaccca  gcctcagaa  ttcagggct  accccagga  tctggtagg  gccacagcc  3060
ggccatgct  cccgttggg  aacagaaac  agtgcccaa  ccaacaccc  ctctttgta  3120
cctaggggg  ttgaatatg  aaagagagt  ctgctggga  cccctatcc  atcagtgat  3180
gtacccaca  aggtagcag  gttagtgtg  atacacaca  acacacaca  acacacaca  3240
acacacccc  tgtcctccg  agtgcctgc  actttctgg  actttctca  ccccctacg  3300
ccttccttt  tcctctccc  cccagacac  gctgctgga  aataaattt  gggatgctg  3360
tgctaaaaa  aaa  3373



<210> 111
<211> 928
<212> PRT
<213> Rattus norvegicus
<308> BAA20359
<400> 111

Met Thr Ala Ser Gln Asn Gln His Arg His Gly Arg Leu Val Leu Phe 
  1               5                  10                  15
Cys Thr Leu Met Gly Thr Leu Cys Lys Ile Gly Val Gly Gln Ile Arg 
             20                  25                  30
Tyr Ser Val Pro Glu Glu Thr Asp Lys Gly Thr Val Val Gly Asn Ile 
         35                  40                  45
Ser Lys Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Glu Arg Gly Val 
     50                  55                  60
Arg Ile Val Ser Arg Gly Arg Ser Gln Leu Phe Ser His Glu Ser Ala 
 65                  70                  75                  80
Gly Arg Asn Leu Val Thr Ala Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                 85                  90                  95
Ala Gln Ser Ile Pro Cys Leu Val Asn Ile Asn Ile Leu Val Glu Glu 
             100                105                110
Lys Gly Lys Leu Phe Gly Val Glu Ile Thr Asp Ile Asn Asp Asn Asn 
         115                120                125
Pro Lys Phe His Val Gly Asp Leu Glu Val Lys Ile Asn Glu Ile Ala 
     130                135                140
Ala Pro Gly Ala Arg Tyr Pro Leu Pro Lys Ala Val Asp Pro Asp Val 
 145                150                155                160
Gly Ile Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn Arg His Phe 
                 165                170                175
Ser Leu Asp Ile Gln Arg Gly Asp Asp Gly Thr Ile Asn Pro Glu Leu 
             180                185                190
Val Leu Glu Asn Thr Leu Asp Arg Glu Glu Glu Pro Ser His His Leu 
         195                200                205
Ile Leu Thr Ala Ser Asp Ala Glu Arg Arg Arg Ser Ser Thr Ala Leu 
     210                215                220
Ile Gln Val Thr Val Leu Asp Thr Asn Asp Asn Ala Pro Val Phe Asp 
 225                230                235                240
Gln Pro Val Tyr Arg Val Lys Val Leu Glu Asn Val Thr Pro Gly Thr 
                 245                250                255
Leu Leu Leu Thr Val Arg Ala Ser Asp Pro Asp Glu Gly Ala Asn Gly 
             260                265                270
Lys Val Thr Tyr Lys Phe Gln Lys Ile Asn Asp Lys Gln Ser Leu Leu 
         275                280                285
Phe His Leu His Glu Asn Thr Gly Glu Met Thr Val Ala Lys Asn Leu 
     290                295                300
Asp Tyr Glu Glu Cys Ser Leu Tyr Glu Met Glu Ile Gln Ala Glu Asp 
 305                310                315                320
Val Gly Ala Leu Leu Gly Arg Ser Lys Val Val Ile Met Val Glu Asp 
                 325                330                335
Val Asn Asp Asn Arg Pro Glu Val Thr Ile Thr Ser Leu Phe Asn Pro 
             340                345                350
Val Leu Glu Asn Ser Leu Pro Gly Thr Val Ile Ala Phe Leu Asn Val 
         355                360                365
His Asp Arg Asp Ser Gly Lys Asn Gly Gln Val Val Cys Tyr Thr His 
     370                375                380
Asp Asn Leu Pro Phe Lys Leu Glu Lys Ser Ile Asp Asn Tyr Tyr Arg 
 385                390                395                400
Leu Val Thr Trp Lys Tyr Leu Asp Arg Glu Lys Val Ser Ile Tyr Asn 
                 405                410                415
Ile Thr Val Ile Ala Ser Asp Leu Gly Ala His Ser Val Thr Glu Thr 
             420                425                430
Tyr Ile Ala Leu Ile Val Ala Asp Thr Asn Asp Asn Pro Pro Arg Phe 
         435                440                445
Pro His Thr Ser Tyr Thr Ala Tyr Ile Pro Glu Asn Asn Leu Arg Gly 
     450                455                460
Ala Ser Ile Phe Ser Leu Thr Ala His Asp Pro Asp Ser Gln Glu Asn 
 465                470                475                480
Ala Gln Val Thr Tyr Ser Val Ser Glu Asp Thr Ile Gln Gly Val Pro 
                 485                490                495
Leu Ser Ser Tyr Ile Ser Ile Asn Ser Asp Thr Gly Val Leu Tyr Ala 
             500                505                510
Leu His Ser Phe Asp Phe Glu Lys Ile Gln Asp Leu Gln Leu Leu Val 
         515                520                525
Val Ala Thr Asp Ser Gly Ser Pro Pro Leu Ser Ser Asn Val Ser Leu 
     530                535                540
Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala Pro Glu Ile Leu Tyr 
 545                550                555                560
Pro Ser Phe Pro Thr Asp Gly Ser Thr Gly Val Glu Leu Ala Pro Arg 
                 565                570                575
Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp Lys 
             580                585                590
Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu Leu Lys Ala Ser 
         595                600                605
Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly Glu Val Arg Thr 
     610                615                620
Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln Asn Leu Val Met 
 625                630                635                640
Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala Thr Val Thr Leu 
                 645                650                655
Thr Val Ala Val Ala Asn Ser Ile Pro Glu Val Leu Ala Asp Leu Ser 
             660                665                670
Ser Ile Arg Thr Pro Gly Val Pro Glu Asp Ser Asp Ile Thr Leu His 
         675                680                685
Leu Val Val Ala Val Ala Val Val Ser Cys Val Phe Leu Val Phe Val 
     690                695                700
Ile Val Leu Leu Ala Leu Arg Leu Gln Arg Trp Gln Lys Ser Arg Gln 
 705                710                715                720
Leu Gln Gly Ser Lys Gly Gly Leu Ala Pro Ala Pro Pro Ser His Phe 
                 725                730                735
Val Gly Ile Asp Gly Val Gln Ala Phe Leu Gln Thr Tyr Ser His Glu 
             740                745                750
Val Ser Leu Thr Ser Gly Ser Gln Thr Ser His Ile Ile Phe Pro Gln 
         755                760                765
Pro Asn Tyr Ala Asp Met Leu Ile Asn Gln Glu Gly Cys Glu Lys Asn 
     770                775                780
Asp Ser Leu Leu Thr Ser Ile Asp Phe His Glu Ser Asn Arg Glu Asp 
 785                790                795                800
Ala Cys Ala Pro Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln 
                 805                810                815
Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Glu Thr Gly 
             820                825                830
Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile 
         835                840                845
Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly 
     850                855                860
Gly Thr Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr 
 865                870                875                880
Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser 
                 885                890                895
Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro 
             900                905                910
Ala Gly Gly Asn Gly Asn Asn Asn Lys Ser Gly Lys Lys Glu Lys Lys 
         915                920                925



<210> 112
<211> 4605
<212> DNA
<213> Homo sapiens
<308> NM_018920
<400> 112

atggcggct  agccgaggg  cggggacta  agaggattc  tcctgctct  catcctcct  60
gggaccccc  gggaagcct  ggcaggacg  attctctac  ccgtgtcgg  ggagacgga  120
aaagggtcc  ttgtgggag  catcgccaa  gacctgggg  tggagcccc  ggagctggc  180
gagcgcgga  tccgcatca  ctccagagg  aggacgcag  ttttcgccc  gaaccagcg  240
agcggcagc  tggtcactg  gggcaggat  gaccgggaa  agatctgcg  tcagagtgc  300
cggtgtctg  taaacttta  catcctgat  gaagataaa  tgaatcttt  ccctataga  360
gtggaaata  tagatatta  tgacaacgt  ccaagattc  tgacggaag  aataaatgt  420
aaaataatg  agaatacag  tcctggggt  cggtttccg  taagcgagg  tggggatcc  480
gatgtgggc  cgaactccc  ccagagtta  cagctcagc  ccaatcgcc  cttctccct  540
gctgtgcaa  gtggagacg  tgaaactaa  tacccggaa  tggtgctgg  gcgggtgct  600
gaccgggag  aagagcggg  tcaccacct  gtcctcaca  cctctgatg  cggcgaccc  660
ccccgatcc  gcaccgccc  catccaggt  acagtggtg  atgtgaatg  ccacacgcc  720
gtcttctct  tgcctcagt  ccaagtaac  gtccccgag  atgtgccag  gggtacaag  780
ctgctcacg  tacatgcta  cgacctgga  gagggagtc  atggggaag  gacatattc  840
tttcggaaa  taactccta  acttccaaa  atgtttcat  tgaactcgc  tacaggaga  900
atatcaact  tagaaggat  agattatga  gaaactgcc  tctatgaaa  ggaggttca  960
gctcaagat  gtcctggta  tctgacaaa  gcaaaagta  tgatcacag  tttagatgt  1020
aatgataat  ctccagaag  gactatgac  tctttaagt  gctcaatcc  tgaagacac  1080
cctcttggg  cagtcattg  tcttttcta  ctacaagac  gagattctg  aaagaatgg  1140
gaggtgacc  gcaccattc  agaaaacct  ccttttaaa  tagaaaaat  aatagataa  1200
tattataga  tggtcacaa  caaaaactt  gaccgggaa  cactctctt  gtataacat  1260
acactgaaa  ccacagatg  tggaactcc  cccttgtcc  gggaaactc  catattcat  1320
caggtggca  acaccaacg  taacccacc  accttcccc  actcatcct  ctcagtcta  1380
atcgctgag  acaacccca  aggggcctc  attttctta  tgactgcac  ggaccacga  1440
agtgaggat  atgcccaga  cacttattc  ttggccgaa  acaccatcc  gggggctcc  1500
gtgtcctcc  atgtctcca  aaactctga  actggagtc  tgtacgcgc  gcaatcctt  1560
gattatgag  agttgagag  actacaact  agagtgact  cacatgaca  cggggaccc  1620
cctctcagc  gcaacatgt  actgagcct  ttcgtgctg  accagaatg  caacccgcc  1680
gagatcctg  acccggccc  ccccacaga  ggttctact  gcatggagc  ggcaccccg  1740
tccgcagag  ccggctacc  ggtgaccaa  gtggtggcg  tggacaaag  ttcaggcca  1800
aacgcctgg  tgtcatacc  cctgcttaa  gccagcgag  caggactct  tgcggttgg  1860
ctgtacacg  gcgaggtgc  cacggctcg  gccctgctg  acagagatg  cctcaagca  1920
agcctcgtg  tggccgtcc  ggaccacgg  cagcctcct  tgtcagcca  cgtcacact  1980
accgtggct  tggctgaca  catccccga  gtcttggcc  acctgggca  ccttgagcc  2040
tccgacggt  cttacaact  tgacctcac  ttgtacctg  tggtggcgg  ggccacagt  2100
tcctgcgtc  tcctagcct  cgtcctcgt  ctgctggcg  tcaggctgc  gcgctggca  2160
aagtcacgc  tgctgcagg  ttcagaagg  ggcttggcg  acgtgccca  ctcgcactt  2220
gtgggcatg  acggggtgc  ggctttcct  cagacctat  cccatgagg  ctccctcac  2280
gcggactct  ggaagagtc  cctgatctt  ccccagccc  actatgtag  catgctcat  2340
agccaggag  gctgtgaga  aaatgattc  ttgctaaca  ccgtagatt  tcaggaatg  2400
aaagaaaac  tgccaagta  tcagcaagc  ccgcccaac  cggactggc  tttctctca  2460
gcccagaga  ccggcacca  cggctccca  aatggcgat  acaccggca  ctggcccaa  2520
aaccagttt  acacagaga  gctgcaagc  atgatcttg  cgtccgcca  tgaagctgc  2580
gatgggagc  ccaccctgg  agggggtgc  ggcaccatg  gattgagcg  ccgctacgg  2640
ccccagttc  ccctgcagc  cgtgcccga  taccgccag  atgtctaca  cccaggcag  2700
aatgccaca  tgaccaacg  agctggcaa  cgggatggc  aggccccag  aggtggcaa  2760
ggcaacaag  agaagtcgg  caagaagga  aagaagtaa  atggaggcc  ggccaagag  2820
cacagggcg  cctctcccc  accagccca  cttctcctt  cctgcaccc  ggcctcaga  2880
tttcagggc  aacccccag  atactggta  gggccaagg  catgctccc  ttgggaaac  2940
gaaacaagt  cccagtcag  acctacccc  tccccccca  ggggttgaa  atgcaaaag  3000
agttccgct  ggaaccccc  tccaatcaa  tgctgtacc  atgggggta  tggggttac  3060
gtagacacc  agaaccatt  gccacaccc  gtttagtta  agctgaact  ctccatctt  3120
caaatcaat  aggcccatc  atcccatgc  tccctcctc  ccaccccac  ccaacagtt  3180
ctctttccc  agtaaggtg  ttggggtgt  gaagtacca  gtaacctac  agcctccta  3240
ttctgaaaa  ttggaaggg  atcatgacc  cttggcctc  cctttgatt  tcaatcttc  3300
cccaaagca  ggtttggtg  cagcccctt  acctccttc  agagcccaa  atcaatgct  3360
aagttttgg  ggacatgat  accatcccc  tggtactga  gcttgctgg  tttagggag  3420
gcattttgc  accaagcct  ttcccaacg  cctggggac  agtcttctg  tttgttttt  3480
attgtttga  gtttccact  catgccttg  cttccccca  ctcctcctc  aacaagaga  3540
tccactgca  gttccaaga  agtatgggg  ggtaagata  ggaagggaa  tgtgtggat  3600
tggatggtg  gggcatgga  aaagcttga  acatcaagt  atcaaggcc  tggaggagg  3660
tctgtatgt  ctcagggga  tgacaacat  ctccagatt  cagccataa  ccaataact  3720
ggctggacc  ttcccacta  ataataggg  tcagcccag  cagccagct  tgggctgag  3780
taacaggac  aatggatta  actggcatt  cagtccaag  aagctcgaa  caggtttag  3840
accaggtcc  cttgagagg  cagaggggc  tctgtgggt  ctgggtact  cagaggtgc  3900
actggtgga  gggtcagcg  agccccagc  ggaagggtg  gccagccag  ccattctta  3960
tccctgggt  ggggaggca  ggagctagg  cagggacca  atgaacaga  agtctcagc  4020
caggatggg  cttcttcaa  agggcccct  ccctcctga  gcctcagtc  ttcaccttg  4080
caggtgccg  ttctcttcc  tgaaggcca  tgcccaggt  cccagtgcg  cccctagtg  4140
ccatagcct  gttaaagtt  cccagtgcc  ccttgtgca  agaccttct  ctcccaccc  4200
cttctgccc  tgggtcccc  gccatccag  ggggctgcc  gagaacccc  gacctgccc  4260
tacagtagt  tagcgcccc  tccctcttt  ggctggtgt  gaatagcca  tagtgtagt  4320
cggtgtgct  ttacgtgat  gcgggtggg  agcgggcgg  gggctccgc  cagccgtct  4380
tccttgatc  gcccgcggc  gcccgtgtt  tgttttgtg  tgtgtccac  cgctaaggc  4440
accccctcc  ccgtactga  ttctcctat  agcgcttct  ttcgcatag  cacgtagct  4500
ccaccccac  ctcttcctg  gtctcacgc  agttttata  tctaatatt  atatggctt  4560
ttttcttcg  caaaaaaat  ataaaacgt  tcttctgaa  agctg  4605



<210> 113
<211> 932
<212> PRT
<213> Homo sapiens
<308> NP_061743
<400> 113

Met Ala Ala Gln Pro Arg Gly Gly Asp Tyr Arg Gly Phe Phe Leu Leu 
  1               5                  10                  15
Ser Ile Leu Leu Gly Thr Pro Trp Glu Ala Trp Ala Gly Arg Ile Leu 
             20                  25                  30
Tyr Ser Val Ser Glu Glu Thr Asp Lys Gly Ser Phe Val Gly Asp Ile 
         35                  40                  45
Ala Lys Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Glu Arg Gly Val 
     50                  55                  60
Arg Ile Ile Ser Arg Gly Arg Thr Gln Leu Phe Ala Leu Asn Gln Arg 
 65                  70                  75                  80
Ser Gly Ser Leu Val Thr Ala Gly Arg Ile Asp Arg Glu Glu Ile Cys 
                 85                  90                  95
Ala Gln Ser Ala Arg Cys Leu Val Asn Phe Asn Ile Leu Met Glu Asp 
             100                105                110
Lys Met Asn Leu Tyr Pro Ile Asp Val Glu Ile Ile Asp Ile Asn Asp 
         115                120                125
Asn Val Pro Arg Phe Leu Thr Glu Glu Ile Asn Val Lys Ile Met Glu 
     130                135                140
Asn Thr Ala Pro Gly Val Arg Phe Pro Leu Ser Glu Ala Gly Asp Pro 
 145                150                155                160
Asp Val Gly Thr Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn Arg 
                 165                170                175
His Phe Ser Leu Ala Val Gln Ser Gly Asp Asp Glu Thr Lys Tyr Pro 
             180                185                190
Glu Leu Val Leu Glu Arg Val Leu Asp Arg Glu Glu Glu Arg Val His 
         195                200                205
His Leu Val Leu Thr Ala Ser Asp Gly Gly Asp Pro Pro Arg Ser Ser 
     210                215                220
Thr Ala His Ile Gln Val Thr Val Val Asp Val Asn Asp His Thr Pro 
 225                230                235                240
Val Phe Ser Leu Pro Gln Tyr Gln Val Thr Val Pro Glu Asn Val Pro 
                 245                250                255
Val Gly Thr Arg Leu Leu Thr Val His Ala Ile Asp Leu Asp Glu Gly 
             260                265                270
Val Asn Gly Glu Val Thr Tyr Ser Phe Arg Lys Ile Thr Pro Lys Leu 
         275                280                285
Pro Lys Met Phe His Leu Asn Ser Leu Thr Gly Glu Ile Ser Thr Leu 
     290                295                300
Glu Gly Leu Asp Tyr Glu Glu Thr Ala Phe Tyr Glu Met Glu Val Gln 
 305                310                315                320
Ala Gln Asp Gly Pro Gly Ser Leu Thr Lys Ala Lys Val Leu Ile Thr 
                 325                330                335
Val Leu Asp Val Asn Asp Asn Ala Pro Glu Val Thr Met Thr Ser Leu 
             340                345                350
Ser Ser Ser Ile Pro Glu Asp Thr Pro Leu Gly Thr Val Ile Ala Leu 
         355                360                365
Phe Tyr Leu Gln Asp Arg Asp Ser Gly Lys Asn Gly Glu Val Thr Cys 
     370                375                380
Thr Ile Pro Glu Asn Leu Pro Phe Lys Leu Glu Lys Ser Ile Asp Asn 
 385                390                395                400
Tyr Tyr Arg Leu Val Thr Thr Lys Asn Leu Asp Arg Glu Thr Leu Ser 
                 405                410                415
Leu Tyr Asn Ile Thr Leu Lys Ala Thr Asp Gly Gly Thr Pro Pro Leu 
             420                425                430
Ser Arg Glu Thr His Ile Phe Met Gln Val Ala Asp Thr Asn Asp Asn 
         435                440                445
Pro Pro Thr Phe Pro His Ser Ser Tyr Ser Val Tyr Ile Ala Glu Asn 
     450                455                460
Asn Pro Arg Gly Ala Ser Ile Phe Leu Val Thr Ala Gln Asp His Asp 
 465                470                475                480
Ser Glu Asp Asn Ala Gln Ile Thr Tyr Ser Leu Ala Glu Asp Thr Ile 
                 485                490                495
Gln Gly Ala Pro Val Ser Ser Tyr Val Ser Ile Asn Ser Asp Thr Gly 
             500                505                510
Val Leu Tyr Ala Leu Gln Ser Phe Asp Tyr Glu Gln Leu Arg Glu Leu 
         515                520                525
Gln Leu Arg Val Thr Ala His Asp Ser Gly Asp Pro Pro Leu Ser Ser 
     530                535                540
Asn Met Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Pro Pro 
 545                550                555                560
Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Met Glu 
                 565                570                575
Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val 
             580                585                590
Ala Val Asp Lys Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Leu Leu 
         595                600                605
Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly Leu Tyr Thr Gly 
     610                615                620
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln 
 625                630                635                640
Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala 
                 645                650                655
Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile Pro Glu Val Leu 
             660                665                670
Ala Asp Leu Gly Ser Leu Glu Pro Ser Asp Gly Pro Tyr Asn Tyr Asp 
         675                680                685
Leu Thr Leu Tyr Leu Val Val Ala Val Ala Thr Val Ser Cys Val Phe 
     690                695                700
Leu Ala Phe Val Leu Val Leu Leu Ala Leu Arg Leu Arg Arg Trp His 
 705                710                715                720
Lys Ser Arg Leu Leu Gln Ala Ser Glu Gly Gly Leu Ala Asn Val Pro 
                 725                730                735
Thr Ser His Phe Val Gly Met Asp Gly Val Gln Ala Phe Leu Gln Thr 
             740                745                750
Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu 
         755                760                765
Ile Phe Pro Gln Pro Asn Tyr Val Asp Met Leu Ile Ser Gln Glu Ser 
     770                775                780
Cys Glu Lys Asn Asp Ser Leu Leu Thr Ser Val Asp Phe Gln Glu Cys 
 785                790                795                800
Lys Glu Asn Leu Pro Ser Ile Gln Gln Ala Pro Pro Asn Thr Asp Trp 
                 805                810                815
Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly 
             820                825                830
Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu 
         835                840                845
Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser 
     850                855                860
Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly 
 865                870                875                880
Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr 
                 885                890                895
Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp 
             900                905                910
Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys 
         915                920                925
Lys Glu Lys Lys 
     930



<210> 114
<211> 1416
<212> DNA
<213> Rattus norvegicus
<308> AB004277
<400> 114

ccgggcctt  ttggaggac  actctgata  ccaacaggt  gtggtcctg  tgagggaca  60
tggtgaccc  tcactatcc  ccacagcaa  agtattgct  gttctggag  acgaggatg  120
agaggaaat  cccaaatcc  gcgacttcc  cacacaccc  cccgagcgg  cagacctca  180
cctttatct  attgtggcg  tggcagctg  cagtctctt  tccctagtt  ccttcactt  240
catgtcagc  aagtgtctg  ggaggcatg  agataggga  cggggtggg  gccagtgct  300
caggggcca  gactcgccc  ccagggagt  ctataaaca  tccagtccc  accttcagg  360
cagctcaga  ggcactcta  agtacatgg  ggtgaccct  cggcccaca  attctcaga  420
ccattgcta  aggacgtgc  tttctccag  ctccgatgg  agtgacttc  ctttcctca  480
gcccctcag  gttcagcag  cctcagcct  ggcgctgga  cccgaggcc  tgcgttccc  540
gtctagtac  ctgcgggag  ggagccagc  agccccgcc  aacactgac  ggcgtttct  600
tcaagccca  agacccggc  cgagcggat  ccaaaatgg  gatgaaacc  gcacctggc  660
caacaacca  ttcgataca  agatgctgc  agccatgat  ttggcctct  ccagtgaag  720
cgctgatgg  agctccact  tgggagggg  cactggcac  atgggtttg  gcgctcgat  780
tggacccca  tttaccctg  agcacgtgc  tgactaccg  cagaacgtg  acatccctg  840
cagcaatgc  acactgacc  acgcagctg  caaacgaga  ggcaaggct  cggcaggcg  900
caatggcaa  aacaacaag  cgggcaaga  agagaagaa  taatatgga  gccaggcct  960
gagccacag  gcagcctcc  tccccagcc  gtccagctt  tccttactt  tacccaggc  1020
tcagaattt  agggctcac  ccaggattc  ggtaggagc  acagccagg  catgctccc  1080
gttgggaaa  agaaacaag  gcccaagcc  acaccccct  tttgtaccc  aggggggtt  1140
aatatgcaa  gagagttct  ctgggaccc  ctatccaat  agtgattgt  cccacatag  1200
tagcagggt  agtgtggat  cacacacac  cacacacac  cacacacac  cacacacaa  1260
caccatgcc  cactcccct  gttacagct  aactcccca  cttccaacc  agtcaggct  1320
attcatctc  agcctccct  tcccaacct  cctttgagt  acacctctc  tttgagcca  1380
gtagttggg  tgttggggt  acaggttga  ctaagg  1416



<210> 115
<211> 313
<212> PRT
<213> Rattus norvegicus
<308> BAA20360
<400> 115

Arg Ala Leu Leu Glu Asp Asp Ser Asp Thr Gln Gln Val Val Val Leu 
  1               5                  10                  15
Val Arg Asp Asn Gly Asp Pro Ser Leu Ser Ser Thr Ala Thr Val Leu 
             20                  25                  30
Leu Val Leu Glu Asp Glu Asp Ala Glu Glu Met Pro Lys Ser Ser Asp 
         35                  40                  45
Phe Leu Thr His Pro Pro Glu Arg Ser Asp Leu Thr Leu Tyr Leu Ile 
     50                  55                  60
Val Ala Leu Ala Ala Val Ser Leu Leu Ser Leu Val Thr Phe Thr Phe 
 65                  70                  75                  80
Met Ser Ala Lys Cys Leu Arg Arg His Glu Asp Arg Asp Arg Gly Gly 
                 85                  90                  95
Gly Gln Cys Cys Arg Gly Gln Asp Ser Pro Ser Arg Glu Phe Tyr Lys 
             100                105                110
Gln Ser Ser Pro Asn Leu Gln Val Ser Ser Asp Gly Thr Leu Lys Tyr 
         115                120                125
Met Glu Val Thr Leu Arg Pro Thr Asp Ser Gln Ser His Cys Tyr Arg 
     130                135                140
Thr Cys Phe Ser Pro Ala Ser Asp Gly Ser Asp Phe Thr Phe Leu Arg 
 145                150                155                160
Pro Leu Ser Val Gln Gln Pro Ser Ala Leu Ala Leu Glu Pro Glu Ala 
                 165                170                175
Leu Arg Ser Arg Ser Ser Thr Leu Arg Glu Arg Ser Gln Gln Ala Pro 
             180                185                190
Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser 
         195                200                205
Gly Ser Gln Asn Gly Asp Glu Thr Gly Thr Trp Pro Asn Asn Gln Phe 
     210                215                220
Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala 
 225                230                235                240
Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Thr Gly Thr Met Gly Leu 
                 245                250                255
Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr 
             260                265                270
Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala 
         275                280                285
Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Asn 
     290                295                300
Asn Lys Ser Gly Lys Lys Glu Lys Lys 
 305                310



<210> 116
<211> 4641
<212> DNA
<213> Homo sapiens
<308> NM_018929
<400> 116

atggggccc  agacactcc  acagctcgc  gggaaatgg  aagtgctgt  catgttgtc  60
ttgtgctgc  ggggctggg  gtctgggca  cttcgttac  cagtggtgg  ggagtctga  120
ccggggacg  tggtgggga  tgttgctca  gatctgggc  taaagatga  agatctgtt  180
agccggcgg  tgcaattgg  ctctgagga  aatgggcgc  atttttccc  gagcttgat  240
agtggtgcc  tggcagtga  tcaaaagat  gaccgagaa  gcctatgtg  agccagcac  300
agctgcctg  tgccagtgc  ggtggtgac  gaacacccc  tggagctaa  ccgtgtaga  360
gtagagatc  tggatctca  tgacaactc  cctagcttt  ccacccctg  gcgagagat  420
cgcatctca  aatcagcag  atctggggc  cgattccca  tggacagtg  ccaggatcc  480
gatgtgggc  ccaatactg  gagctttta  actctaagc  ccaacagcc  cttctctct  540
aatgtgaag  ccctaaaag  tgggaagcc  ttcccagag  tggtgctag  gcagcagct  600
gatcgtgaa  cccaggcaa  acatcagct  gtgcttact  ctgtggatg  ggggacccc  660
gcccgctca  ggaccaccc  tatctctgt  atcgtgctg  acatcaatg  taatgctcc  720
accttccaa  cctcagttc  acgtgtggg  atcccagag  atgcaccca  tggtactct  780
ctgctccgc  tcaatgcca  tgatccaga  gagggcacc  acggccaac  agactattc  840
tttggagac  acacatctg  ggcagtgcg  aacctcttt  gcctagacc  tagcagtgg  900
gcaatccat  tgttgggtc  catagactt  gaggagtca  gtttctatg  aattcatgc  960
agagcccgt  accagggac  gcctgccat  gagggccac  gtgtgattc  agtggatgt  1020
ggggatgtc  atgacaatg  cccagaggt  ctattggcc  ctttggcca  ccctgtcct  1080
gagagcaca  cagtgggca  agtagtggg  ttgtttaat  tgcgagacc  ggactcagg  1140
agaaatggt  aagtgagcc  tgatatctc  ccggacctg  catttcaga  taagccttc  1200
gagaaccac  actcgctgc  aaccagcca  cctttggac  gggaggcca  atcccacta  1260
atcatcgag  tgctggcca  cgatgctgg  tcaccttcc  tacacaaac  tctcaccat  1320
aggctcaac  tttcagatg  caatgacaa  gcaccccgc  tcaaccagc  gctttacac  1380
gcttacatc  tagaaaacc  gcctccggg  tcccttctt  gcactgtgg  tgcctcaga  1440
ccagacact  gggataatg  ccgcctcac  tactccatt  taggaaatc  ggttcaggg  1500
gccccagcc  cctcctttg  gtatgtcaa  ccagaggat  gacggatct  tgcccagcg  1560
acctttgac  atgaattgc  gcagatgct  cagattgtg  tgggggttc  agactccgg  1620
tctccccca  tgcatgcca  cacatctct  catgtgttt  tcctagacg  gaatgataa  1680
gccccagct  tgctgcacc  acggccaga  tgggaacac  cagcccccc  gcgtctccc  1740
cgctctgct  ctcctggct  cttggtcac  aaggtgaca  ccgtggatg  tgatgcagg  1800
cacaatgcg  ggctctcct  ctcactgtt  ccacagtcc  cagccccag  actgttcct  1860
gtgtctaca  acactggtg  ggtgcgcac  gcccgggcc  tactggagg  tgactctga  1920
acccagcag  tggtggtcc  ggtgaggga  aatggtgac  cttcactct  ctccacagc  1980
acagtgctg  tggttctgg  ggatgagga  cctgaggaa  tgcccaaat  cagtgactt  2040
ctcatacac  ctcctgagc  ttcagacct  accctttac  tcattgtgg  tctagcgac  2100
gtcagtctc  tatccctag  caccttcac  tttctgtca  cgaagtgcc  tcagggaaa  2160
gcagacggg  acgggggtg  agggcagtg  tgcaggcgc  aggactcac  ctccccgga  2220
ttctataag  agtccagcc  caacctgca  gtgagctcg  acggcacgc  caagtacat  2280
gaggtgacg  tgcggccca  agactcgca  agccactgc  acaggacgt  cttttcacc  2340
gcctcggac  gcagtgact  cacttttct  agacccctc  gcgttcagc  gcccacagc  2400
ctggcgctg  agcctgacg  catccggtc  cgctctaat  cgctgcggg  gcggagcca  2460
caagccccg  ccaacacgg  ctggcgttt  tctcaggcc  agagacccg  caccagcgg  2520
tcccaaaat  gcgatgaca  cggcacctg  cccaacaac  agtttgaca  agagatgct  2580
caagccatg  tcttggcgt  cgccagtga  gctgctgat  ggagctcca  cctgggagg  2640
ggtgccggc  ccatgggat  gagcgcccg  tacggaccc  agttcaccc  gcagcacgt  2700
cccgactac  gccagaatg  ctacatccc  ggcagcaat  ccacactga  caacgcagc  2760
ggcaagcgg  atggcaagg  cccagcagg  ggcaatggc  acaagaaga  gtcgggcaa  2820
aaggagaag  agtaacatg  aggccaggc  aagagccac  gggcggcct  tccccaacc  2880
gcccagctt  tccttacct  cacccaggc  tcagagttt  agggctaac  cccagaata  2940
tggtagggg  caaggccat  ctccccttg  gaaacagaa  caagtgccc  gtcagcacc  3000
accccttcc  ccccagggg  ttgaatatg  aaaagcagt  ccgctggga  cccccatcc  3060
atcaactgc  gtacccatg  gggtagtgg  gttactgta  acaccaaga  ccatttgcc  3120
caccccgtt  agttacagc  gaactcctc  atcttccaa  tcaatcagg  ccatccatc  3180
catgcctcc  tcctcccca  cccactcca  cagttcctc  ttcccgagt  aggtggttg  3240
ggtgttgaa  taccaagta  cctacaagc  tcctagttc  gaaaagttg  aagggcatc  3300
tgacctctt  gcctctcct  tgattctca  tcttccccc  aagcatggt  tggtgccag  3360
cccttcacc  ccttccaga  cccaagatc  atgctcaag  tttggagga  atgatcacc  3420
tccccatgg  actgatgct  gctggattt  gggagggca  tttgctacc  agcctcttc  3480
caacgccct  gggaccagt  ttctgtttt  tttttcatt  tttgacgtt  ccactgcat  3540
ccttgactt  ccccacctc  tcctcaaac  agagactcc  ctgcatgtt  caagacagt  3600
tggggtggt  agataagga  gggaagtgt  tggatgtgg  tggtggggg  atggacaaa  3660
cttgacaca  caagttatc  aggccttgg  ggaggctct  tatgtcctc  ggggactga  3720
aacatcctc  agattccag  cataaacca  taactaggc  ggacccttc  cactacata  3780
tagggctca  cccaggcag  cagctttgg  ctgagctaa  aggaccaat  gattaaact  3840
gcatttcag  ccaaggaag  tcgaagcag  tttaggacc  ggtcccctt  agaggtcag  3900
ggggcctct  tgggtgctg  gtactccag  ggtgccact  gtggaaggg  cagcggagc  3960
ccagcagga  gggtgggcc  gccaggcca  tcttagtcc  tgggttggg  aggcaggga  4020
ctagggcag  gaccaaatg  acagaaagt  tcagcccag  atggggctt  ttcaacagg  4080
cccctgccc  cctgaagcc  cagtccttc  ccttgccag  tgccgtttc  cttccgtga  4140
ggccactgc  caggtcccc  gtgcgcccc  tagtggcca  agcctggtt  aagttcccc  4200
gtgcctcct  gtgcataga  cttcttctc  caccccctt  tgcccctgg  tccccggcc  4260
tccagcggg  ctgccagag  accccagac  tgcccttac  gtagtgtag  gccccctcc  4320
tctttcggc  ggtgtagaa  agccagtag  gtagtgcgg  gtgctttta  gtgatggcg  4380
gtgggcagc  ggcggcggg  tccgcgcag  cgtctgtcc  tgatctgcc  gcggcggcc  4440
gtgttgtgt  ttgtgctgt  tccacgcgc  aaggcgacc  cctcccccg  actgacttc  4500
cctataagc  cttctcttc  catagtcac  tagctccca  cccaccctc  tcctgtgtc  4560
cacgcaagt  ttatactct  atatttata  ggctttttt  cttcgacaa  aaaataata  4620
aacgtttct  ctgaaaagc  g  4641



<210> 117
<211> 944
<212> PRT
<213> Homo sapiens
<308> NP_061752
<400> 117

Met Gly Pro Lys Thr Leu Pro Gln Leu Ala Gly Lys Trp Gln Val Leu 
  1               5                  10                  15
Cys Met Leu Ser Leu Cys Cys Trp Gly Trp Val Ser Gly Gln Leu Arg 
             20                  25                  30
Tyr Ser Val Val Glu Glu Ser Glu Pro Gly Thr Leu Val Gly Asn Val 
         35                  40                  45
Ala Gln Asp Leu Gly Leu Lys Met Thr Asp Leu Leu Ser Arg Arg Leu 
     50                  55                  60
Gln Leu Gly Ser Glu Glu Asn Gly Arg Tyr Phe Ser Leu Ser Leu Met 
 65                  70                  75                  80
Ser Gly Ala Leu Ala Val Asn Gln Lys Ile Asp Arg Glu Ser Leu Cys 
                 85                  90                  95
Gly Ala Ser Thr Ser Cys Leu Leu Pro Val Gln Val Val Thr Glu His 
             100                105                110
Pro Leu Glu Leu Ile Arg Val Glu Val Glu Ile Leu Asp Leu Asn Asp 
         115                120                125
Asn Ser Pro Ser Phe Ala Thr Pro Glu Arg Glu Met Arg Ile Ser Glu 
     130                135                140
Ser Ala Ala Ser Gly Ala Arg Phe Pro Leu Asp Ser Ala Gln Asp Pro 
 145                150                155                160
Asp Val Gly Thr Asn Thr Val Ser Phe Tyr Thr Leu Ser Pro Asn Ser 
                 165                170                175
His Phe Ser Leu Asn Val Lys Thr Leu Lys Asp Gly Lys Pro Phe Pro 
             180                185                190
Glu Leu Val Leu Glu Gln Gln Leu Asp Arg Glu Ala Gln Ala Arg His 
         195                200                205
Gln Leu Val Leu Thr Ala Val Asp Gly Gly Thr Pro Ala Arg Ser Gly 
     210                215                220
Thr Thr Leu Ile Ser Val Ile Val Leu Asp Ile Asn Asp Asn Ala Pro 
 225                230                235                240
Thr Phe Gln Ser Ser Val Leu Arg Val Gly Ile Pro Glu Asn Ala Pro 
                 245                250                255
Ile Gly Thr Leu Leu Leu Arg Leu Asn Ala Thr Asp Pro Asp Glu Gly 
             260                265                270
Thr Asn Gly Gln Leu Asp Tyr Ser Phe Gly Asp His Thr Ser Glu Ala 
         275                280                285
Val Arg Asn Leu Phe Gly Leu Asp Pro Ser Ser Gly Ala Ile His Val 
     290                295                300
Leu Gly Pro Ile Asp Phe Glu Glu Ser Arg Phe Tyr Glu Ile His Ala 
 305                310                315                320
Arg Ala Arg Asp Gln Gly Gln Pro Ala Met Glu Gly His Cys Val Ile 
                 325                330                335
Gln Val Asp Val Gly Asp Val Asn Asp Asn Ala Pro Glu Val Leu Leu 
             340                345                350
Ala Ser Leu Ala Asn Pro Val Leu Glu Ser Thr Pro Val Gly Thr Val 
         355                360                365
Val Gly Leu Phe Asn Val Arg Asp Arg Asp Ser Gly Arg Asn Gly Glu 
     370                375                380
Val Ser Leu Asp Ile Ser Pro Asp Leu Pro Phe Gln Ile Lys Pro Ser 
 385                390                395                400
Glu Asn His Tyr Ser Leu Leu Thr Ser Gln Pro Leu Asp Arg Glu Ala 
                 405                410                415
Thr Ser His Tyr Ile Ile Glu Leu Leu Ala Ser Asp Ala Gly Ser Pro 
             420                425                430
Ser Leu His Lys His Leu Thr Ile Arg Leu Asn Ile Ser Asp Val Asn 
         435                440                445
Asp Asn Ala Pro Arg Phe Asn Gln Gln Leu Tyr Thr Ala Tyr Ile Leu 
     450                455                460
Glu Asn Arg Pro Pro Gly Ser Leu Leu Cys Thr Val Ala Ala Ser Asp 
 465                470                475                480
Pro Asp Thr Gly Asp Asn Ala Arg Leu Thr Tyr Ser Ile Val Gly Asn 
                 485                490                495
Gln Val Gln Gly Ala Pro Ala Ser Ser Phe Val Tyr Val Asn Pro Glu 
             500                505                510
Asp Gly Arg Ile Phe Ala Gln Arg Thr Phe Asp Tyr Glu Leu Leu Gln 
         515                520                525
Met Leu Gln Ile Val Val Gly Val Arg Asp Ser Gly Ser Pro Pro Leu 
     530                535                540
His Ala Asn Thr Ser Leu His Val Phe Val Leu Asp Glu Asn Asp Asn 
 545                550                555                560
Ala Pro Ala Val Leu His Pro Arg Pro Asp Trp Glu His Ser Ala Pro 
                 565                570                575
Gln Arg Leu Pro Arg Ser Ala Pro Pro Gly Ser Leu Val Thr Lys Val 
             580                585                590
Thr Ala Val Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr Ser 
         595                600                605
Leu Leu Pro Gln Ser Thr Ala Pro Gly Leu Phe Leu Val Ser Thr His 
     610                615                620
Thr Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Glu Asp Asp Ser Asp 
 625                630                635                640
Thr Gln Gln Val Val Val Leu Val Arg Asp Asn Gly Asp Pro Ser Leu 
                 645                650                655
Ser Ser Thr Ala Thr Val Leu Leu Val Leu Glu Asp Glu Asp Pro Glu 
             660                665                670
Glu Met Pro Lys Ser Ser Asp Phe Leu Ile His Pro Pro Glu Arg Ser 
         675                680                685
Asp Leu Thr Leu Tyr Leu Ile Val Ala Leu Ala Thr Val Ser Leu Leu 
     690                695                700
Ser Leu Val Thr Phe Thr Phe Leu Ser Ala Lys Cys Leu Gln Gly Asn 
 705                710                715                720
Ala Asp Gly Asp Gly Gly Gly Gly Gln Cys Cys Arg Arg Gln Asp Ser 
                 725                730                735
Pro Ser Pro Asp Phe Tyr Lys Gln Ser Ser Pro Asn Leu Gln Val Ser 
             740                745                750
Ser Asp Gly Thr Leu Lys Tyr Met Glu Val Thr Leu Arg Pro Thr Asp 
         755                760                765
Ser Gln Ser His Cys Tyr Arg Thr Cys Phe Ser Pro Ala Ser Asp Gly 
     770                775                780
Ser Asp Phe Thr Phe Leu Arg Pro Leu Ser Val Gln Gln Pro Thr Ala 
 785                790                795                800
Leu Ala Leu Glu Pro Asp Ala Ile Arg Ser Arg Ser Asn Thr Leu Arg 
                 805                810                815
Glu Arg Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln 
             820                825                830
Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly 
         835                840                845
Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile 
     850                855                860
Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly 
 865                870                875                880
Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr 
                 885                890                895
Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser 
             900                905                910
Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro 
         915                920                925
Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
     930                935                940



<210> 118
<211> 1416
<212> DNA
<213> Rattus norvegicus
<308> AB004277
<400> 118

ccgggcctt  ttggaggac  actctgata  ccaacaggt  gtggtcctg  tgagggaca  60
tggtgaccc  tcactatcc  ccacagcaa  agtattgct  gttctggag  acgaggatg  120
agaggaaat  cccaaatcc  gcgacttcc  cacacaccc  cccgagcgg  cagacctca  180
cctttatct  attgtggcg  tggcagctg  cagtctctt  tccctagtt  ccttcactt  240
catgtcagc  aagtgtctg  ggaggcatg  agataggga  cggggtggg  gccagtgct  300
caggggcca  gactcgccc  ccagggagt  ctataaaca  tccagtccc  accttcagg  360
cagctcaga  ggcactcta  agtacatgg  ggtgaccct  cggcccaca  attctcaga  420
ccattgcta  aggacgtgc  tttctccag  ctccgatgg  agtgacttc  ctttcctca  480
gcccctcag  gttcagcag  cctcagcct  ggcgctgga  cccgaggcc  tgcgttccc  540
gtctagtac  ctgcgggag  ggagccagc  agccccgcc  aacactgac  ggcgtttct  600
tcaagccca  agacccggc  cgagcggat  ccaaaatgg  gatgaaacc  gcacctggc  660
caacaacca  ttcgataca  agatgctgc  agccatgat  ttggcctct  ccagtgaag  720
cgctgatgg  agctccact  tgggagggg  cactggcac  atgggtttg  gcgctcgat  780
tggacccca  tttaccctg  agcacgtgc  tgactaccg  cagaacgtg  acatccctg  840
cagcaatgc  acactgacc  acgcagctg  caaacgaga  ggcaaggct  cggcaggcg  900
caatggcaa  aacaacaag  cgggcaaga  agagaagaa  taatatgga  gccaggcct  960
gagccacag  gcagcctcc  tccccagcc  gtccagctt  tccttactt  tacccaggc  1020
tcagaattt  agggctcac  ccaggattc  ggtaggagc  acagccagg  catgctccc  1080
gttgggaaa  agaaacaag  gcccaagcc  acaccccct  tttgtaccc  aggggggtt  1140
aatatgcaa  gagagttct  ctgggaccc  ctatccaat  agtgattgt  cccacatag  1200
tagcagggt  agtgtggat  cacacacac  cacacacac  cacacacac  cacacacaa  1260
caccatgcc  cactcccct  gttacagct  aactcccca  cttccaacc  agtcaggct  1320
attcatctc  agcctccct  tcccaacct  cctttgagt  acacctctc  tttgagcca  1380
gtagttggg  tgttggggt  acaggttga  ctaagg  1416



<210> 119
<211> 313
<212> PRT
<213> Rattus norvegicus
<308> BAA20360
<400> 119

Arg Ala Leu Leu Glu Asp Asp Ser Asp Thr Gln Gln Val Val Val Leu 
  1               5                  10                  15
Val Arg Asp Asn Gly Asp Pro Ser Leu Ser Ser Thr Ala Thr Val Leu 
             20                  25                  30
Leu Val Leu Glu Asp Glu Asp Ala Glu Glu Met Pro Lys Ser Ser Asp 
         35                  40                  45
Phe Leu Thr His Pro Pro Glu Arg Ser Asp Leu Thr Leu Tyr Leu Ile 
     50                  55                  60
Val Ala Leu Ala Ala Val Ser Leu Leu Ser Leu Val Thr Phe Thr Phe 
 65                  70                  75                  80
Met Ser Ala Lys Cys Leu Arg Arg His Glu Asp Arg Asp Arg Gly Gly 
                 85                  90                  95
Gly Gln Cys Cys Arg Gly Gln Asp Ser Pro Ser Arg Glu Phe Tyr Lys 
             100                105                110
Gln Ser Ser Pro Asn Leu Gln Val Ser Ser Asp Gly Thr Leu Lys Tyr 
         115                120                125
Met Glu Val Thr Leu Arg Pro Thr Asp Ser Gln Ser His Cys Tyr Arg 
     130                135                140
Thr Cys Phe Ser Pro Ala Ser Asp Gly Ser Asp Phe Thr Phe Leu Arg 
 145                150                155                160
Pro Leu Ser Val Gln Gln Pro Ser Ala Leu Ala Leu Glu Pro Glu Ala 
                 165                170                175
Leu Arg Ser Arg Ser Ser Thr Leu Arg Glu Arg Ser Gln Gln Ala Pro 
             180                185                190
Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser 
         195                200                205
Gly Ser Gln Asn Gly Asp Glu Thr Gly Thr Trp Pro Asn Asn Gln Phe 
     210                215                220
Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala 
 225                230                235                240
Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Thr Gly Thr Met Gly Leu 
                 245                250                255
Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr 
             260                265                270
Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala 
         275                280                285
Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Asn 
     290                295                300
Asn Lys Ser Gly Lys Lys Glu Lys Lys 
 305                310



<210> 120
<211> 4641
<212> DNA
<213> Homo sapiens
<308> NM_018929
<400> 120

atggggccc  agacactcc  acagctcgc  gggaaatgg  aagtgctgt  catgttgtc  60
ttgtgctgc  ggggctggg  gtctgggca  cttcgttac  cagtggtgg  ggagtctga  120
ccggggacg  tggtgggga  tgttgctca  gatctgggc  taaagatga  agatctgtt  180
agccggcgg  tgcaattgg  ctctgagga  aatgggcgc  atttttccc  gagcttgat  240
agtggtgcc  tggcagtga  tcaaaagat  gaccgagaa  gcctatgtg  agccagcac  300
agctgcctg  tgccagtgc  ggtggtgac  gaacacccc  tggagctaa  ccgtgtaga  360
gtagagatc  tggatctca  tgacaactc  cctagcttt  ccacccctg  gcgagagat  420
cgcatctca  aatcagcag  atctggggc  cgattccca  tggacagtg  ccaggatcc  480
gatgtgggc  ccaatactg  gagctttta  actctaagc  ccaacagcc  cttctctct  540
aatgtgaag  ccctaaaag  tgggaagcc  ttcccagag  tggtgctag  gcagcagct  600
gatcgtgaa  cccaggcaa  acatcagct  gtgcttact  ctgtggatg  ggggacccc  660
gcccgctca  ggaccaccc  tatctctgt  atcgtgctg  acatcaatg  taatgctcc  720
accttccaa  cctcagttc  acgtgtggg  atcccagag  atgcaccca  tggtactct  780
ctgctccgc  tcaatgcca  tgatccaga  gagggcacc  acggccaac  agactattc  840
tttggagac  acacatctg  ggcagtgcg  aacctcttt  gcctagacc  tagcagtgg  900
gcaatccat  tgttgggtc  catagactt  gaggagtca  gtttctatg  aattcatgc  960
agagcccgt  accagggac  gcctgccat  gagggccac  gtgtgattc  agtggatgt  1020
ggggatgtc  atgacaatg  cccagaggt  ctattggcc  ctttggcca  ccctgtcct  1080
gagagcaca  cagtgggca  agtagtggg  ttgtttaat  tgcgagacc  ggactcagg  1140
agaaatggt  aagtgagcc  tgatatctc  ccggacctg  catttcaga  taagccttc  1200
gagaaccac  actcgctgc  aaccagcca  cctttggac  gggaggcca  atcccacta  1260
atcatcgag  tgctggcca  cgatgctgg  tcaccttcc  tacacaaac  tctcaccat  1320
aggctcaac  tttcagatg  caatgacaa  gcaccccgc  tcaaccagc  gctttacac  1380
gcttacatc  tagaaaacc  gcctccggg  tcccttctt  gcactgtgg  tgcctcaga  1440
ccagacact  gggataatg  ccgcctcac  tactccatt  taggaaatc  ggttcaggg  1500
gccccagcc  cctcctttg  gtatgtcaa  ccagaggat  gacggatct  tgcccagcg  1560
acctttgac  atgaattgc  gcagatgct  cagattgtg  tgggggttc  agactccgg  1620
tctccccca  tgcatgcca  cacatctct  catgtgttt  tcctagacg  gaatgataa  1680
gccccagct  tgctgcacc  acggccaga  tgggaacac  cagcccccc  gcgtctccc  1740
cgctctgct  ctcctggct  cttggtcac  aaggtgaca  ccgtggatg  tgatgcagg  1800
cacaatgcg  ggctctcct  ctcactgtt  ccacagtcc  cagccccag  actgttcct  1860
gtgtctaca  acactggtg  ggtgcgcac  gcccgggcc  tactggagg  tgactctga  1920
acccagcag  tggtggtcc  ggtgaggga  aatggtgac  cttcactct  ctccacagc  1980
acagtgctg  tggttctgg  ggatgagga  cctgaggaa  tgcccaaat  cagtgactt  2040
ctcatacac  ctcctgagc  ttcagacct  accctttac  tcattgtgg  tctagcgac  2100
gtcagtctc  tatccctag  caccttcac  tttctgtca  cgaagtgcc  tcagggaaa  2160
gcagacggg  acgggggtg  agggcagtg  tgcaggcgc  aggactcac  ctccccgga  2220
ttctataag  agtccagcc  caacctgca  gtgagctcg  acggcacgc  caagtacat  2280
gaggtgacg  tgcggccca  agactcgca  agccactgc  acaggacgt  cttttcacc  2340
gcctcggac  gcagtgact  cacttttct  agacccctc  gcgttcagc  gcccacagc  2400
ctggcgctg  agcctgacg  catccggtc  cgctctaat  cgctgcggg  gcggagcca  2460
caagccccg  ccaacacgg  ctggcgttt  tctcaggcc  agagacccg  caccagcgg  2520
tcccaaaat  gcgatgaca  cggcacctg  cccaacaac  agtttgaca  agagatgct  2580
caagccatg  tcttggcgt  cgccagtga  gctgctgat  ggagctcca  cctgggagg  2640
ggtgccggc  ccatgggat  gagcgcccg  tacggaccc  agttcaccc  gcagcacgt  2700
cccgactac  gccagaatg  ctacatccc  ggcagcaat  ccacactga  caacgcagc  2760
ggcaagcgg  atggcaagg  cccagcagg  ggcaatggc  acaagaaga  gtcgggcaa  2820
aaggagaag  agtaacatg  aggccaggc  aagagccac  gggcggcct  tccccaacc  2880
gcccagctt  tccttacct  cacccaggc  tcagagttt  agggctaac  cccagaata  2940
tggtagggg  caaggccat  ctccccttg  gaaacagaa  caagtgccc  gtcagcacc  3000
accccttcc  ccccagggg  ttgaatatg  aaaagcagt  ccgctggga  cccccatcc  3060
atcaactgc  gtacccatg  gggtagtgg  gttactgta  acaccaaga  ccatttgcc  3120
caccccgtt  agttacagc  gaactcctc  atcttccaa  tcaatcagg  ccatccatc  3180
catgcctcc  tcctcccca  cccactcca  cagttcctc  ttcccgagt  aggtggttg  3240
ggtgttgaa  taccaagta  cctacaagc  tcctagttc  gaaaagttg  aagggcatc  3300
tgacctctt  gcctctcct  tgattctca  tcttccccc  aagcatggt  tggtgccag  3360
cccttcacc  ccttccaga  cccaagatc  atgctcaag  tttggagga  atgatcacc  3420
tccccatgg  actgatgct  gctggattt  gggagggca  tttgctacc  agcctcttc  3480
caacgccct  gggaccagt  ttctgtttt  tttttcatt  tttgacgtt  ccactgcat  3540
ccttgactt  ccccacctc  tcctcaaac  agagactcc  ctgcatgtt  caagacagt  3600
tggggtggt  agataagga  gggaagtgt  tggatgtgg  tggtggggg  atggacaaa  3660
cttgacaca  caagttatc  aggccttgg  ggaggctct  tatgtcctc  ggggactga  3720
aacatcctc  agattccag  cataaacca  taactaggc  ggacccttc  cactacata  3780
tagggctca  cccaggcag  cagctttgg  ctgagctaa  aggaccaat  gattaaact  3840
gcatttcag  ccaaggaag  tcgaagcag  tttaggacc  ggtcccctt  agaggtcag  3900
ggggcctct  tgggtgctg  gtactccag  ggtgccact  gtggaaggg  cagcggagc  3960
ccagcagga  gggtgggcc  gccaggcca  tcttagtcc  tgggttggg  aggcaggga  4020
ctagggcag  gaccaaatg  acagaaagt  tcagcccag  atggggctt  ttcaacagg  4080
cccctgccc  cctgaagcc  cagtccttc  ccttgccag  tgccgtttc  cttccgtga  4140
ggccactgc  caggtcccc  gtgcgcccc  tagtggcca  agcctggtt  aagttcccc  4200
gtgcctcct  gtgcataga  cttcttctc  caccccctt  tgcccctgg  tccccggcc  4260
tccagcggg  ctgccagag  accccagac  tgcccttac  gtagtgtag  gccccctcc  4320
tctttcggc  ggtgtagaa  agccagtag  gtagtgcgg  gtgctttta  gtgatggcg  4380
gtgggcagc  ggcggcggg  tccgcgcag  cgtctgtcc  tgatctgcc  gcggcggcc  4440
gtgttgtgt  ttgtgctgt  tccacgcgc  aaggcgacc  cctcccccg  actgacttc  4500
cctataagc  cttctcttc  catagtcac  tagctccca  cccaccctc  tcctgtgtc  4560
cacgcaagt  ttatactct  atatttata  ggctttttt  cttcgacaa  aaaataata  4620
aacgtttct  ctgaaaagc  g  4641



<210> 121
<211> 944
<212> PRT
<213> Homo sapiens
<308> NP_061752
<400> 121

Met Gly Pro Lys Thr Leu Pro Gln Leu Ala Gly Lys Trp Gln Val Leu 
  1               5                  10                  15
Cys Met Leu Ser Leu Cys Cys Trp Gly Trp Val Ser Gly Gln Leu Arg 
             20                  25                  30
Tyr Ser Val Val Glu Glu Ser Glu Pro Gly Thr Leu Val Gly Asn Val 
         35                  40                  45
Ala Gln Asp Leu Gly Leu Lys Met Thr Asp Leu Leu Ser Arg Arg Leu 
     50                  55                  60
Gln Leu Gly Ser Glu Glu Asn Gly Arg Tyr Phe Ser Leu Ser Leu Met 
 65                  70                  75                  80
Ser Gly Ala Leu Ala Val Asn Gln Lys Ile Asp Arg Glu Ser Leu Cys 
                 85                  90                  95
Gly Ala Ser Thr Ser Cys Leu Leu Pro Val Gln Val Val Thr Glu His 
             100                105                110
Pro Leu Glu Leu Ile Arg Val Glu Val Glu Ile Leu Asp Leu Asn Asp 
         115                120                125
Asn Ser Pro Ser Phe Ala Thr Pro Glu Arg Glu Met Arg Ile Ser Glu 
     130                135                140
Ser Ala Ala Ser Gly Ala Arg Phe Pro Leu Asp Ser Ala Gln Asp Pro 
 145                150                155                160
Asp Val Gly Thr Asn Thr Val Ser Phe Tyr Thr Leu Ser Pro Asn Ser 
                 165                170                175
His Phe Ser Leu Asn Val Lys Thr Leu Lys Asp Gly Lys Pro Phe Pro 
             180                185                190
Glu Leu Val Leu Glu Gln Gln Leu Asp Arg Glu Ala Gln Ala Arg His 
         195                200                205
Gln Leu Val Leu Thr Ala Val Asp Gly Gly Thr Pro Ala Arg Ser Gly 
     210                215                220
Thr Thr Leu Ile Ser Val Ile Val Leu Asp Ile Asn Asp Asn Ala Pro 
 225                230                235                240
Thr Phe Gln Ser Ser Val Leu Arg Val Gly Ile Pro Glu Asn Ala Pro 
                 245                250                255
Ile Gly Thr Leu Leu Leu Arg Leu Asn Ala Thr Asp Pro Asp Glu Gly 
             260                265                270
Thr Asn Gly Gln Leu Asp Tyr Ser Phe Gly Asp His Thr Ser Glu Ala 
         275                280                285
Val Arg Asn Leu Phe Gly Leu Asp Pro Ser Ser Gly Ala Ile His Val 
     290                295                300
Leu Gly Pro Ile Asp Phe Glu Glu Ser Arg Phe Tyr Glu Ile His Ala 
 305                310                315                320
Arg Ala Arg Asp Gln Gly Gln Pro Ala Met Glu Gly His Cys Val Ile 
                 325                330                335
Gln Val Asp Val Gly Asp Val Asn Asp Asn Ala Pro Glu Val Leu Leu 
             340                345                350
Ala Ser Leu Ala Asn Pro Val Leu Glu Ser Thr Pro Val Gly Thr Val 
         355                360                365
Val Gly Leu Phe Asn Val Arg Asp Arg Asp Ser Gly Arg Asn Gly Glu 
     370                375                380
Val Ser Leu Asp Ile Ser Pro Asp Leu Pro Phe Gln Ile Lys Pro Ser 
 385                390                395                400
Glu Asn His Tyr Ser Leu Leu Thr Ser Gln Pro Leu Asp Arg Glu Ala 
                 405                410                415
Thr Ser His Tyr Ile Ile Glu Leu Leu Ala Ser Asp Ala Gly Ser Pro 
             420                425                430
Ser Leu His Lys His Leu Thr Ile Arg Leu Asn Ile Ser Asp Val Asn 
         435                440                445
Asp Asn Ala Pro Arg Phe Asn Gln Gln Leu Tyr Thr Ala Tyr Ile Leu 
     450                455                460
Glu Asn Arg Pro Pro Gly Ser Leu Leu Cys Thr Val Ala Ala Ser Asp 
 465                470                475                480
Pro Asp Thr Gly Asp Asn Ala Arg Leu Thr Tyr Ser Ile Val Gly Asn 
                 485                490                495
Gln Val Gln Gly Ala Pro Ala Ser Ser Phe Val Tyr Val Asn Pro Glu 
             500                505                510
Asp Gly Arg Ile Phe Ala Gln Arg Thr Phe Asp Tyr Glu Leu Leu Gln 
         515                520                525
Met Leu Gln Ile Val Val Gly Val Arg Asp Ser Gly Ser Pro Pro Leu 
     530                535                540
His Ala Asn Thr Ser Leu His Val Phe Val Leu Asp Glu Asn Asp Asn 
 545                550                555                560
Ala Pro Ala Val Leu His Pro Arg Pro Asp Trp Glu His Ser Ala Pro 
                 565                570                575
Gln Arg Leu Pro Arg Ser Ala Pro Pro Gly Ser Leu Val Thr Lys Val 
             580                585                590
Thr Ala Val Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr Ser 
         595                600                605
Leu Leu Pro Gln Ser Thr Ala Pro Gly Leu Phe Leu Val Ser Thr His 
     610                615                620
Thr Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Glu Asp Asp Ser Asp 
 625                630                635                640
Thr Gln Gln Val Val Val Leu Val Arg Asp Asn Gly Asp Pro Ser Leu 
                 645                650                655
Ser Ser Thr Ala Thr Val Leu Leu Val Leu Glu Asp Glu Asp Pro Glu 
             660                665                670
Glu Met Pro Lys Ser Ser Asp Phe Leu Ile His Pro Pro Glu Arg Ser 
         675                680                685
Asp Leu Thr Leu Tyr Leu Ile Val Ala Leu Ala Thr Val Ser Leu Leu 
     690                695                700
Ser Leu Val Thr Phe Thr Phe Leu Ser Ala Lys Cys Leu Gln Gly Asn 
 705                710                715                720
Ala Asp Gly Asp Gly Gly Gly Gly Gln Cys Cys Arg Arg Gln Asp Ser 
                 725                730                735
Pro Ser Pro Asp Phe Tyr Lys Gln Ser Ser Pro Asn Leu Gln Val Ser 
             740                745                750
Ser Asp Gly Thr Leu Lys Tyr Met Glu Val Thr Leu Arg Pro Thr Asp 
         755                760                765
Ser Gln Ser His Cys Tyr Arg Thr Cys Phe Ser Pro Ala Ser Asp Gly 
     770                775                780
Ser Asp Phe Thr Phe Leu Arg Pro Leu Ser Val Gln Gln Pro Thr Ala 
 785                790                795                800
Leu Ala Leu Glu Pro Asp Ala Ile Arg Ser Arg Ser Asn Thr Leu Arg 
                 805                810                815
Glu Arg Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln 
             820                825                830
Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly 
         835                840                845
Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile 
     850                855                860
Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly 
 865                870                875                880
Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr 
                 885                890                895
Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser 
             900                905                910
Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro 
         915                920                925
Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
     930                935                940



<210> 122
<211> 924
<212> DNA
<213> Rattus norvegicus
<308> AB006802
<400> 122

cttgatttc  agcagttcc  gaccctaca  ctgggagtg  ccgctagtg  cagtggaaa  60
ccaccatta  gaagcaata  ttcactgac  cttttcgtg  tggaccaga  tgacaacac  120
ccagagatc  tatacccct  tctccctac  gatggctcc  ctggtgtgg  attggcgcc  180
cgctccgca  agccaggtt  tttagtgac  aaggtggtg  ctgtagaca  agactccgg  240
cagaacgct  ggctgtcct  ccgcctgct  aaagccagc  agccaggcc  cttctccgt  300
gggctgcac  cgggggagg  gcgcacggc  cgagccatg  tggacaaag  tgctctcaa  360
cagagcctc  ttgtaactg  gcaggatca  ggccagcct  ctctctccg  cactgtcag  420
ctcaccgtg  cggtggctg  cagcatccc  gaggttctg  aggacttgg  tagtctaga  480
tctcctgcc  acccggatg  gtcgagtct  accctctac  tagtggtgg  catcactgc  540
gtctcctgc  tcttcctca  ctttgtcat  gtactgctg  ctctcaggc  tcggcgctg  600
agctcatca  gtctgctcc  ggctgccag  ggattggct  gcgtgcctc  ttcgcactt  660
gtgggtgtg  acgggatgc  tgctttcct  cagacctat  cccacgaag  ttcgctcac  720
gcagactca  ggaagagtc  cctgatctt  ccgcagccc  actatgcag  cacgctcat  780
ctagctcag  agacctgtg  gaaaagcga  cctctacta  tacctgaag  ctcagctac  840
gttttaggc  aatgtgagc  aaccgatat  cagcaagcc  cgcccaaca  tgactggcg  900
ttctctcaa  cccagagac  caaa  924



<210> 123
<211> 308
<212> PRT
<213> Rattus norvegicus
<308> BAA22078
<400> 123

Leu Asp Phe Glu Gln Phe Gln Thr Leu Gln Leu Gly Val Thr Ala Ser 
  1               5                  10                  15
Asp Ser Gly Asn Pro Pro Leu Arg Ser Asn Ile Ser Leu Thr Leu Phe 
             20                  25                  30
Val Leu Asp Gln Asn Asp Asn Thr Pro Glu Ile Leu Tyr Pro Ser Leu 
         35                  40                  45
Pro Thr Asp Gly Ser Thr Gly Val Glu Leu Ala Pro Arg Ser Ala Glu 
     50                  55                  60
Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp Arg Asp Ser Gly 
 65                  70                  75                  80
Gln Asn Ala Trp Leu Ser Tyr Arg Leu Leu Lys Ala Ser Glu Pro Gly 
                 85                  90                  95
Leu Phe Ser Val Gly Leu His Thr Gly Glu Val Arg Thr Ala Arg Ala 
             100                105                110
Met Met Asp Lys Asp Ala Leu Lys Gln Ser Leu Val Val Thr Val Gln 
         115                120                125
Asp His Gly Gln Pro Pro Leu Ser Ala Thr Val Arg Leu Thr Val Ala 
     130                135                140
Val Ala Asp Ser Ile Pro Glu Val Leu Glu Asp Leu Val Ser Leu Glu 
 145                150                155                160
Ser Pro Ala Asn Pro Asp Glu Ser Ser Leu Thr Leu Tyr Leu Val Val 
                 165                170                175
Ala Ile Thr Ala Val Ser Cys Ile Phe Leu Ile Phe Val Ile Val Leu 
             180                185                190
Leu Ala Leu Arg Leu Arg Arg Trp Ser Ser Ser Arg Leu Leu Gln Ala 
         195                200                205
Ala Ser Gly Leu Ala Gly Val Pro Pro Ser His Phe Val Gly Val Asp 
     210                215                220
Gly Met His Ala Phe Leu Gln Thr Tyr Ser His Glu Val Ser Leu Thr 
 225                230                235                240
Ala Asp Ser Arg Lys Ser His Leu Ile Phe Pro Gln Pro Asn Tyr Ala 
                 245                250                255
Asp Thr Leu Ile Leu Ala Gln Glu Thr Cys Gly Lys Ser Glu Pro Leu 
             260                265                270
Leu Ile Pro Glu Asp Ser Ala Thr Val Leu Gly Lys Cys Glu Pro Thr 
         275                280                285
Asp Ile Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala 
     290                295                300
Gln Arg Pro Lys 
 305



<210> 124
<211> 4872
<212> DNA
<213> Homo sapiens
<308> NM_018914
<400> 124

agaatgggc  ctaggcgcc  ctgctcacc  atcagggaa  gggaagctg  gcgccattg  60
gtccctccc  cccccgcct  taccacaca  agcggaatg  gatggatac  cacagatcc  120
gacactgga  acttagaag  attttcctt  gctttctga  atattttgg  tgtagtcgg  180
ctaggactt  atagataca  aagccgatt  acaaccaac  agctcgaga  accgcggaa  240
atcggctta  agcctgcca  ggcgaatcg  ctacagcgc  gggaccgca  tcggctgct  300
ctgctgctg  gcattttcc  ggggacgct  cgggggttc  gggccaggc  gatccgata  360
tcggtgcca  aagagaccg  aaagggctc  ttcgtgggc  atatctcca  ggacctggg  420
ctggagccc  gggagctgg  gaagcgcgg  gtccgcatc  tctccagag  gaagacaca  480
cttttcgct  tgaatccgc  aagcggcag  ttgatcacg  caggcagga  agaccggga  540
gagctctgt  agacggtgt  ctcctgttt  ttaaatatg  aacttctcg  ggaagacac  600
ttgaagatt  acggagtgg  ggtggaaat  atagatatt  atgataacg  ccccagctt  660
caggaggac  aagtggaga  aaaagtcag  gagcacgca  ttcctgggg  gcgatttgc  720
cttcctaat  ctagggatc  agatgtggg  gtgaactcc  tccagagct  ccagctcag  780
cctaataat  acttttcct  gcaactgcg  ggcagaacg  atggggcca  gaatccaga  840
ctagtactg  agggaagcc  ggaccgaga  aaagaggct  ctcacctgc  cctcctcac  900
gctttagat  gaggcgatc  catccgaaa  ggcgcagtt  ccattcgtg  ggtggtcct  960
gatgtaaat  atcacatcc  aatgtttac  cagtccgta  atcgcgtga  tgttccaga  1020
aacatcagc  ccggaactc  ggtgctgat  gttaatgca  cggatccag  cgagggaat  1080
aacggggaa  taatgtatt  atttcggaa  atggaaagc  aggcttctg  aatattcca  1140
ttggattca  aaactggag  agttcaagt  cgggggtct  tggattttg  aaaatatag  1200
ttctatgag  tggaaattc  aggccaaga  ggtggaggt  tctttacca  cacgacgat  1260
ttgatcact  ttgtggatg  gaatgataa  gctccagaa  taactatca  ctcttctat  1320
aattcaatt  tggaaaact  tcctccagg  acagtgatt  ctcttctaa  tgtgcaaga  1380
caagattct  gagaaaatg  tcaagtctc  tgttttatt  ctaaccacc  gccttttaa  1440
ttagaaaag  cttatggaa  ttattacaa  ttgataaca  gcagagtgc  ggacaggga  1500
ttggtccag  gctacaata  aacgttgac  gccacagac  agggaagcc  gcctttgtc  1560
gcagaaact  atgtctggc  gaatgtggc  gatgacaac  ataaccctc  cgtttttcc  1620
cactcctct  actctgcct  cattcccga  aacaacccc  ggggtgcct  catcttctc  1680
gtgaccgcc  tcgacccgg  cagcaaaca  aatgccctg  tcacttact  tctgacgga  1740
gacactgtc  agggggtgc  tctgtcctc  tatgtctct  ttaactcca  cactggtgt  1800
ctctatgcc  tacaatcct  cgactatga  cagtttcga  acttagaac  gagagtgat  1860
gcacgtgac  gcggggacc  gcccctcag  agcaacgtg  cgctgagcc  gttcgtgct  1920
gaccagaac  acaatgcgc  cgagatcct  taccctgcc  tccccacag  cggctccac  1980
ggcgtggag  tggcgcccc  ctctgcgga  cctggctac  tggtgacca  ggtggttgc  2040
gtggacaaa  attcaggcc  gaacgcctg  ctgtcctat  gcctgctta  ggccagcga  2100
ccgggactc  tcgcggtgg  ggagcacac  ggcgaggtg  gtacagcgc  ggcactgct  2160
gacagagac  cgctcaagc  gagcctcgt  gtggccgtc  aggaccacg  ccagccccc  2220
ctctcggcc  ccgtcacgc  caccgtggc  gtggccgac  gcatccccg  agtcctggc  2280
gacctcggc  gcctcgagt  tctggctaa  tctgaaacc  cagacctct  gctgtactt  2340
gtggtggcg  tggccgcag  ctcctgcat  ttcctggtc  ttgtcatcg  gctgctggc  2400
ctcaggctg  ggcgctggc  taagtcacg  ctgctgcag  cttctgaag  cgggttggc  2460
ggtatgccc  cgtcacatt  tgtaggcgt  gacggggta  aggctttcc  gcaaaccta  2520
tcccacgag  tctctctca  tgcggactc  cagaagagt  acctgattt  cccccagcc  2580
aactatggg  acacgctca  cagccagga  agctgtgag  aaagcgagc  actcttgat  2640
gctgaagac  cagctatca  tttaggcaa  tgtgacccg  caagtaatc  gcaagcccc  2700
cccaacacg  actggcgtt  ctctcaggc  cagagaccc  gcaccagcg  ctcccaaaa  2760
ggcgatgac  ccggcacct  gcccaacaa  cagtttgac  cagagatgc  gcaagccat  2820
atcttggcg  ccgccagtg  agctgctga  gggagctcc  ccctgggag  gggtgccgg  2880
accatggga  tgagcgccc  ctacggacc  cagttcacc  tgcagcacg  gcccgacta  2940
cgccagaat  tctacatcc  aggcagcaa  gccacactg  ccaacgcag  tggcaagcg  3000
gatggcaag  ccccagcag  tggcaatgg  aacaagaag  agtcgggca  gaaggagaa  3060
aagtaacat  gaggccagg  caagagcca  agggcggcc  ctccccaac  agcccagct  3120
ctccttacc  gcacccagg  ctcagagtt  cagggctaa  ccccagaat  ctggtaggg  3180
ccaaggcca  gctcccctt  ggaaacaga  acaagtgcc  agtcagcac  taccccttc  3240
cccccaggg  gttgaatat  caaaagcag  tccgctggg  acccccatc  aatcaactg  3300
tgtacccat  ggggtagtg  ggttactgt  gacaccaag  accatttgc  acaccccgt  3360
tagttacag  tgaactcct  catcttcca  atcaatcag  cccatccat  ccatgcctc  3420
ctcctcccc  ccccactcc  acagttcct  tttcccgag  aaggtggtt  gggtgttga  3480
gtaccaagt  acctacaag  ctcctagtt  tgaaaagtt  gaagggcat  atgacctct  3540
ggcctctcc  ttgattctc  atcttcccc  aaagcatgg  ttggtgcca  ccccttcac  3600
tccttccag  gcccaagat  aatgctcaa  ttttggagg  catgatcac  atccccatg  3660
tactgatgc  tgctggatt  agggagggc  ttttgctac  aagcctctt  ccaacgccc  3720
ggggaccag  cttctgttt  gtttttcat  gtttgacgt  tccactgca  gccttgact  3780
cccccacct  ctcctcaaa  aagagactc  actgcatgt  ccaagacag  atggggtgg  3840
aagataagg  agggaagtg  gtggatgtg  atggtgggg  catggacaa  gcttgacac  3900
tcaagttat  aaggccttg  aggaggctc  gtatgtcct  aggggactg  caacatcct  3960
cagattcca  ccataaacc  ataactagg  tggaccctt  ccactacat  atagggctc  4020
gcccaggca  ccagctttg  gctgagcta  caggaccaa  ggattaaac  ggcatttca  4080
tccaaggaa  ctcgaagca  gtttaggac  aggtcccct  gagaggtca  aggggcctc  4140
gtgggtgct  ggtactcca  aggtgccac  ggtggaagg  tcagcggag  cccagcagg  4200
agggtgggc  agccaggcc  ttcttagtc  ctgggttgg  gaggcaggg  gctagggca  4260
ggaccaaat  aacagaaag  ctcagccca  gatggggct  cttcaacag  gcccctgcc  4320
tcctgaagc  tcagtcctt  accttgcca  gtgccgttt  tcttccgtg  aggccactg  4380
ccaggtccc  agtgcgccc  ctagtggcc  tagcctggt  aaagttccc  agtgcctcc  4440
tgtgcatag  ccttcttct  ccaccccct  ctgcccctg  gtccccggc  atccagcgg  4500
gctgccaga  aaccccaga  ctgccctta  agtagtgta  cgccccctc  ctctttcgg  4560
tggtgtaga  tagccagta  tgtagtgcg  tgtgctttt  cgtgatggc  ggtgggcag  4620
gggcggcgg  ctccgcgca  ccgtctgtc  ttgatctgc  cgcggcggc  cgtgttgtg  4680
tttgtgctg  gtccacgcg  taaggcgac  ccctccccc  tactgactt  tcctataag  4740
gcttctctt  gcatagtca  gtagctccc  ccccaccct  ttcctgtgt  tcacgcaag  4800
tttatactc  aatatttat  tggcttttt  tcttcgaca  aaaaataat  aaacgtttc  4860
tctgaaaag  tg  4872



<210> 125
<211> 935
<212> PRT
<213> Homo sapiens
<308> NP_061737
<400> 125

Met Ala Asn Arg Leu Gln Arg Gly Asp Arg Ser Arg Leu Leu Leu Leu 
  1               5                  10                  15
Leu Cys Ile Phe Leu Gly Thr Leu Arg Gly Phe Arg Ala Arg Gln Ile 
             20                  25                  30
Arg Tyr Ser Val Pro Glu Glu Thr Glu Lys Gly Ser Phe Val Gly Asn 
         35                  40                  45
Ile Ser Lys Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Lys Arg Gly 
     50                  55                  60
Val Arg Ile Val Ser Arg Gly Lys Thr Gln Leu Phe Ala Val Asn Pro 
 65                  70                  75                  80
Arg Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu 
                 85                  90                  95
Cys Glu Thr Val Ser Ser Cys Phe Leu Asn Met Glu Leu Leu Val Glu 
             100                105                110
Asp Thr Leu Lys Ile Tyr Gly Val Glu Val Glu Ile Ile Asp Ile Asn 
         115                120                125
Asp Asn Ala Pro Ser Phe Gln Glu Asp Glu Val Glu Ile Lys Val Ser 
     130                135                140
Glu His Ala Ile Pro Gly Ala Arg Phe Ala Leu Pro Asn Ala Arg Asp 
 145                150                155                160
Pro Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn 
                 165                170                175
Asn Tyr Phe Ser Leu Gln Leu Arg Gly Arg Thr Asp Gly Ala Lys Asn 
             180                185                190
Pro Glu Leu Val Leu Glu Gly Ser Leu Asp Arg Glu Lys Glu Ala Ala 
         195                200                205
His Leu Leu Leu Leu Thr Ala Leu Asp Gly Gly Asp Pro Ile Arg Lys 
     210                215                220
Gly Ala Val Pro Ile Arg Val Val Val Leu Asp Val Asn Asp His Ile 
 225                230                235                240
Pro Met Phe Thr Gln Ser Val Tyr Arg Val Ser Val Pro Glu Asn Ile 
                 245                250                255
Ser Ser Gly Thr Arg Val Leu Met Val Asn Ala Thr Asp Pro Asp Glu 
             260                265                270
Gly Ile Asn Gly Glu Val Met Tyr Ser Phe Arg Asn Met Glu Ser Lys 
         275                280                285
Ala Ser Glu Ile Phe Gln Leu Asp Ser Gln Thr Gly Glu Val Gln Val 
     290                295                300
Arg Gly Ser Leu Asp Phe Glu Lys Tyr Arg Phe Tyr Glu Met Glu Ile 
 305                310                315                320
Gln Gly Gln Asp Gly Gly Gly Leu Phe Thr Thr Thr Thr Met Leu Ile 
                 325                330                335
Thr Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Ile Thr Ser 
             340                345                350
Ser Ile Asn Ser Ile Leu Glu Asn Ser Pro Pro Gly Thr Val Ile Ala 
         355                360                365
Leu Leu Asn Val Gln Asp Gln Asp Ser Gly Glu Asn Gly Gln Val Ser 
     370                375                380
Cys Phe Ile Pro Asn His Leu Pro Phe Lys Leu Glu Lys Thr Tyr Gly 
 385                390                395                400
Asn Tyr Tyr Lys Leu Ile Thr Ser Arg Val Leu Asp Arg Glu Leu Val 
                 405                410                415
Gln Ser Tyr Asn Ile Thr Leu Thr Ala Thr Asp Gln Gly Ser Pro Pro 
             420                425                430
Leu Ser Ala Glu Thr His Val Trp Leu Asn Val Ala Asp Asp Asn Asp 
         435                440                445
Asn Pro Pro Val Phe Pro His Ser Ser Tyr Ser Ala Tyr Ile Pro Glu 
     450                455                460
Asn Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Thr Ala Leu Asp Pro 
 465                470                475                480
Asp Ser Lys Gln Asn Ala Leu Val Thr Tyr Ser Leu Thr Asp Asp Thr 
                 485                490                495
Val Gln Gly Val Pro Leu Ser Ser Tyr Val Ser Ile Asn Ser Asn Thr 
             500                505                510
Gly Val Leu Tyr Ala Leu Gln Ser Phe Asp Tyr Glu Gln Phe Arg Asp 
         515                520                525
Leu Glu Leu Arg Val Ile Ala Arg Asp Ser Gly Asp Pro Pro Leu Ser 
     530                535                540
Ser Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala 
 545                550                555                560
Pro Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val 
                 565                570                575
Glu Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val 
             580                585                590
Val Ala Val Asp Lys Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg 
         595                600                605
Leu Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly Glu His Thr 
     610                615                620
Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys 
 625                630                635                640
Gln Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser 
                 645                650                655
Ala Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile Pro Glu Val 
             660                665                670
Leu Ala Asp Leu Gly Ser Leu Glu Ser Leu Ala Asn Ser Glu Thr Ser 
         675                680                685
Asp Leu Ser Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Ile 
     690                695                700
Phe Leu Val Phe Val Ile Val Leu Leu Ala Leu Arg Leu Trp Arg Trp 
 705                710                715                720
His Lys Ser Arg Leu Leu Gln Ala Ser Glu Gly Gly Leu Ala Gly Met 
                 725                730                735
Pro Thr Ser His Phe Val Gly Val Asp Gly Val Gln Ala Phe Leu Gln 
             740                745                750
Thr Tyr Ser His Glu Val Ser Leu Ile Ala Asp Ser Gln Lys Ser His 
         755                760                765
Leu Ile Phe Pro Gln Pro Asn Tyr Gly Asp Thr Leu Ile Ser Gln Glu 
     770                775                780
Ser Cys Glu Lys Ser Glu Pro Leu Leu Ile Ala Glu Asp Ser Ala Ile 
 785                790                795                800
Ile Leu Gly Lys Cys Asp Pro Thr Ser Asn Gln Gln Ala Pro Pro Asn 
                 805                810                815
Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser 
             820                825                830
Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr 
         835                840                845
Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp 
     850                855                860
Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala 
 865                870                875                880
Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln 
                 885                890                895
Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly 
             900                905                910
Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys 
         915                920                925
Ser Gly Lys Lys Glu Lys Lys 
     930                935



<210> 126
<211> 775
<212> DNA
<213> Rattus norvegicus
<308> AB006881
<400> 126

ttttttttt  tttttgcca  gctggattt  cgcttttaa  gatcagtat  aataatacc  60
tgcttgttt  ggttacact  tccctctaa  agacagccc  tctaattga  gcgtctggg  120
tagtctaga  tggtagtga  tgaaccaac  accaattat  ttattcatt  cactgaact  180
cgctgatgg  ctccacgag  aagaaggga  tgttgagaa  cctgccctt  tgatgaaga  240
gttgcctgc  aatatataa  aacctgggt  tcacaggca  tctgaatgc  tgggcgccc  300
gttttacat  cgagaaaca  gaggaatcc  ctcgaaagc  tagggactc  gagtacaaa  360
agaagcatt  gtatggcgt  gcccgatca  tcgaaatca  agagaaatt  cagctatcc  420
agctttatt  atcctgccc  cgtttcttc  attaggctg  gtacatatc  tgccttcaa  480
agcaccgaa  gtctgccat  ctatcaaat  catgatgta  atatatatt  cccataagt  540
aagctgatg  accgccatc  tttccacat  gccatacat  cacattggc  gggctgggg  600
ggggaatca  taattactt  atataaact  gcgggcaac  tcttacaga  ctgtacgct  660
tgaagcgtc  tctaccaag  ggtgccaag  aacagttaa  ttacagccg  acgggaggc  720
tcaacaaaa  acatggtac  gttgttgta  acttcccag  tcagcgtgc  ggtgc  775



<210> 127
<211> 1514
<212> DNA
<213> Rattus norvegicus
<308> AB007690
<400> 127

atgtgccgc  cggggagca  ctgccgagc  ggcggagag  gaacgccag  ggccccgtc  60
gagcggcca  aggagcagc  ccggagatg  gagagcagc  catcttcac  acgcgagcg  120
acgtcttcc  gattgaccc  agcaccaag  agaactggg  gccggcaag  aagcaggcc  180
tcactgttt  ctacttcta  gatgtcacc  ggaacagct  tcggatcat  agtgtggat  240
gagccaagg  aatcataaa  agcaccatc  ccccgaaca  gacgttcac  aaaacttca  300
agaagttcg  gcagtgggc  gacagcagg  ccaacaccg  gttcggtct  ggattctcc  360
cagagcagc  gctcacaaa  tttgcagag  aattccagg  ggtaagaga  gctgccagg  420
tagccagag  caagtccca  gagaaaatc  agacgtcaa  taatcattc  caagcatcc  480
gcgtcaatg  gacagatga  gagaaagcc  cccatgcga  tccggccga  acacacctc  540
agtctgaga  tgacaagct  aagatcgct  tgacacaga  tgctgccaa  gtgaagaag  600
gggagatcg  gctgcagac  ctgcgggag  gcaatgccc  gctgaccac  gcgctgcag  660
agtcggcgg  cagtgtaga  cagtggaag  ggcaattct  catctgcag  gatgagaat  720
acaggctcc  cagcaagat  gaggagctg  aagaacagt  cggtgagat  aacagggag  780
aggaaaaga  cacccagct  aagaggagg  ttgaggagc  ggagtcaga  gtccgagaa  840
aggaaatgg  gttgaagga  ctccgcaaa  aaagtgaaa  catacctca  ctcatgtcc  900
agtgtgaat  tgtctctga  aagttagag  ctgcagaaa  agacaatca  aacttggaa  960
acaaagtgc  gtctctaaa  acagacatc  aggagagta  ataccggca  cgccacctg  1020
agggggagc  caagagctt  cttgaggtg  tggacggaa  gatcgatga  ctccacgac  1080
tccgccgag  gctctccaa  ctaggcacg  ataactagg  tggggcgga  cctagatgg  1140
gagtggaaa  cgtgtgtga  agatgaagt  ggcataggg  attctccgt  tgcttctgt  1200
atgcgggtg  gttctgtct  tctccaggc  agtcgtgcc  tccactcgc  cctccagaa  1260
agaaaatct  ttgcttctc  ggctttgtg  ggtcgtgga  acctggaag  ttctgactc  1320
ggaatccag  acggtctac  ttagccgtt  acgcagtca  ggcagggac  ttcagatct  1380
cccttaagg  ctgttgcaa  cctatgaac  ggggatggg  gaagtattt  ctaatccaa  1440
tatcattaa  ctttacaac  ggcctttgg  cgccttccg  tgcgtggca  tcagtgtgt  1500
agactctag  ttcc  1514



<210> 128
<211> 343
<212> PRT
<213> Rattus norvegicus
<308> BAA32479
<400> 128

Met Gly Glu Gln Pro Ile Phe Thr Thr Arg Ala His Val Phe Gln Ile 
  1               5                  10                  15
Asp Pro Ser Thr Lys Lys Asn Trp Val Pro Ala Ser Lys Gln Ala Val 
             20                  25                  30
Thr Val Ser Tyr Phe Tyr Asp Val Thr Arg Asn Ser Tyr Arg Ile Ile 
         35                  40                  45
Ser Val Asp Gly Ala Lys Val Ile Ile Asn Ser Thr Ile Thr Pro Asn 
     50                  55                  60
Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp Ala Asp Ser 
 65                  70                  75                  80
Arg Ala Asn Thr Val Phe Gly Leu Gly Phe Ser Ser Glu Gln Gln Leu 
                 85                  90                  95
Thr Lys Phe Ala Glu Lys Phe Gln Glu Val Arg Glu Ala Ala Arg Leu 
             100                105                110
Ala Arg Asp Lys Ser Gln Glu Lys Ile Glu Thr Ser Ser Asn His Ser 
         115                120                125
Gln Ala Ser Ser Val Asn Gly Thr Asp Asp Glu Lys Ala Ser His Ala 
     130                135                140
Ser Pro Ala Asp Thr His Leu Lys Ser Glu Asn Asp Lys Leu Lys Ile 
 145                150                155                160
Ala Leu Thr Gln Ser Ala Ala Asn Val Lys Lys Trp Glu Ile Glu Leu 
                 165                170                175
Gln Thr Leu Arg Glu Ser Asn Ala Arg Leu Thr Thr Ala Leu Gln Glu 
             180                185                190
Ser Ala Ala Ser Val Glu Gln Trp Lys Arg Gln Phe Ser Ile Cys Arg 
         195                200                205
Asp Glu Asn Asp Arg Leu Arg Ser Lys Ile Glu Glu Leu Glu Glu Gln 
     210                215                220
Cys Gly Glu Ile Asn Arg Glu Lys Glu Lys Asn Thr Gln Leu Lys Arg 
 225                230                235                240
Arg Ile Glu Glu Leu Glu Ser Glu Val Arg Glu Lys Glu Met Glu Leu 
                 245                250                255
Lys Asp Leu Arg Lys Gln Ser Glu Ile Ile Pro Gln Leu Met Ser Glu 
             260                265                270
Cys Glu Tyr Val Ser Glu Lys Leu Glu Ala Ala Glu Arg Asp Asn Gln 
         275                280                285
Asn Leu Glu Asp Lys Val Arg Ser Leu Lys Thr Asp Ile Glu Glu Ser 
     290                295                300
Lys Tyr Arg Gln Arg His Leu Lys Gly Glu Leu Lys Ser Phe Leu Glu 
 305                310                315                320
Val Leu Asp Gly Lys Ile Asp Asp Leu His Asp Phe Arg Arg Gly Leu 
                 325                330                335
Ser Lys Leu Gly Thr Asp Asn 
             340



<210> 129
<211> 1972
<212> DNA
<213> Homo sapiens
<308> BC012109
<400> 129

cgcgcctgg  ggcggtggc  gcagtggca  cagtggcag  cgcgcagcc  cgcggaatg  60
agcggcgcc  gggctgagc  gggcgcgca  gggccgccg  atgtgccgc  cggggagcg  120
ctgccgagc  ggcggagag  gagcgcgag  ggccccgtc  gagcggccg  cggagcagc  180
ccggagatg  gagaacagc  catcttcac  acccgagcg  atgtcttcc  gattgaccc  240
aacaccaag  agaactgga  gcctgcgag  aagcaggcg  tcaccgttt  ctacttcta  300
gatgtcaca  ggaacagct  tcggatcat  agtgtggac  gagccaagg  gatcataaa  360
agcacaatc  caccgaata  gaccttcac  aaaacgtca  agaagtttg  gcagtgggc  420
gacagcaga  ccaacacag  gtttggttt  gggttttcc  ctgagcagc  gctgacaaa  480
tttgcagag  aattccagg  ggtgaaaga  gctgccaag  tagccaaag  caagacgca  540
gagaaaatc  agacctcaa  taatcattc  caagcatcc  gtgtcaacg  gacggacga  600
gaaaaggcc  ctcacgccg  tccagccaa  acacacctg  agtctgaga  tgacaagct  660
aagattgcc  tgacgcaga  cgcagccaa  gtgaagaag  gggagatcg  gctgcagac  720
cttcgggag  gcaatgcac  gctgaccac  gcactgcag  agtcggcag  cagtgtgga  780
cagtggaag  ggcagttct  catctgccg  gatgagaat  accggctcc  caacaagat  840
gatgagctg  aagaacaat  cagtgagat  aacagagag  aggagaaga  cacgcagct  900
aagaggagg  tcgaggagc  ggaggcaga  ctccgagaa  aggagacag  gctgaaaga  960
ctccgaaaa  aaagtgaaa  catacctca  ctcatgtca  agtgcgaat  tgtctctga  1020
aagctagag  cggcagaga  agacaatca  aacctggaa  acaaagtgc  ttccttaaa  1080
acagacatt  aggagagca  ataccgaca  cgccacctg  aggtggagt  gaagagctt  1140
ctggaggtg  tggacggga  gattgacga  ctgcatgac  tccgccgag  gctctccaa  1200
ctgggcacc  ataactagg  ctggccgag  cccaggccc  gcccgtgag  cccaagcgt  1260
tgtgcgaga  cagatagct  taggacgtt  ttctgtgtg  attgcttct  taaatgcag  1320
cgcagtttg  cgtgtttcc  aaccagttg  gccgtccac  cactccttt  cagaataga  1380
atctcctct  gcttctctg  ccttgtgag  ttgtggaca  ctggaagat  ctgactcag  1440
aatccagaa  taggtctac  ttcaacatt  atgcagtca  ggcagggat  tttatatct  1500
tcataaggg  tgttgcaac  atatgaact  aaaaaacac  cattttgta  tccaaatat  1560
gatattctt  acaccaagc  atcaggctc  ttttatcaa  tagcattca  agtatttga  1620
tgtccacca  acaccagcc  cggggggca  agagagaac  acattcctc  ctgtcaaca  1680
cgagaggct  taaaacaac  gtttagtgg  aactttctg  gagatggaa  acaagcttc  1740
ggtgggtgc  ttttctggc  cggagttgc  tgcatccac  ctactgccc  ctgcccccc  1800
cccccccag  ttgtacggt  gcaacagtg  tccttttct  ggttttaat  tctgagcag  1860
tgattgtgc  gtgggaaca  cacacagtg  gggtgccta  cacaatgtc  ggcacaaag  1920
aggtgctta  taaatattt  ttcaattaa  aaaaaaaaa  aaaaaaaaa  aa  1972



<210> 130
<211> 354
<212> PRT
<213> Homo sapiens
<308> XP_054356
<400> 130

Met Gly Glu Gln Pro Ile Phe Thr Thr Arg Ala His Val Phe Gln Ile 
  1               5                  10                  15
Asp Pro Asn Thr Lys Lys Asn Trp Met Pro Ala Ser Lys Gln Ala Val 
             20                  25                  30
Thr Val Ser Tyr Phe Tyr Asp Val Thr Arg Asn Ser Tyr Arg Ile Ile 
         35                  40                  45
Ser Val Asp Gly Ala Lys Val Ile Ile Asn Ser Thr Ile Thr Pro Asn 
     50                  55                  60
Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp Ala Asp Ser 
 65                  70                  75                  80
Arg Ala Asn Thr Val Phe Gly Leu Gly Phe Ser Ser Glu Gln Gln Leu 
                 85                  90                  95
Thr Lys Phe Ala Glu Lys Phe Gln Glu Val Lys Glu Ala Ala Lys Ile 
             100                105                110
Ala Lys Asp Lys Thr Gln Glu Lys Ile Glu Thr Ser Ser Asn His Ser 
         115                120                125
Gln Glu Ser Gly Arg Glu Thr Pro Ser Ser Thr Gln Ala Ser Ser Val 
     130                135                140
Asn Gly Thr Asp Asp Glu Lys Ala Ser His Ala Gly Pro Ala Asn Thr 
 145                150                155                160
His Leu Lys Ser Glu Asn Asp Lys Leu Lys Ile Ala Leu Thr Gln Ser 
                 165                170                175
Ala Ala Asn Val Lys Lys Trp Glu Ile Glu Leu Gln Thr Leu Arg Glu 
             180                185                190
Ser Asn Ala Arg Leu Thr Thr Ala Leu Gln Glu Ser Ala Ala Ser Val 
         195                200                205
Glu Gln Trp Lys Arg Gln Phe Ser Ile Cys Arg Asp Glu Asn Asp Arg 
     210                215                220
Leu Arg Asn Lys Ile Asp Glu Leu Glu Glu Gln Cys Ser Glu Ile Asn 
 225                230                235                240
Arg Glu Lys Glu Lys Asn Thr Gln Leu Lys Arg Arg Ile Glu Glu Leu 
                 245                250                255
Glu Ala Glu Leu Arg Glu Lys Glu Thr Glu Leu Lys Asp Leu Arg Lys 
             260                265                270
Gln Ser Glu Ile Ile Pro Gln Leu Met Ser Glu Cys Glu Tyr Val Ser 
         275                280                285
Glu Lys Leu Glu Ala Ala Glu Arg Asp Asn Gln Asn Leu Glu Asp Lys 
     290                295                300
Val Arg Ser Leu Lys Thr Asp Ile Glu Glu Ser Lys Tyr Arg Gln Arg 
 305                310                315                320
His Leu Lys Val Glu Leu Lys Ser Phe Leu Glu Val Leu Asp Gly Lys 
                 325                330                335
Ile Asp Asp Leu His Asp Phe Arg Arg Gly Leu Ser Lys Leu Gly Thr 
             340                345                350
Asp Asn 
         355



<210> 131
<211> 747
<212> DNA
<213> Rattus norvegicus
<308> AB008521
<400> 131

cacgattac  gagacgagc  cctggactt  atccaggcg  atctgcggg  attctgcct  60
cagtatgga  ctgccttga  ttacacctc  gtgaaggaa  agaaaaacc  tgacttgct  120
tataagtac  ttgttcata  aacatacgg  ttccacttc  ccatacccg  cttagttgt  180
gaaaaggac  cagttttta  acctgcagg  tgggacaat  aaaagaaaa  agctatttt  240
catgaaaat  ttacaaccg  gaagccaga  gatgcatat  aagatttta  tgtaaagcc  300
cctgtgaga  agctggtcc  tgacaaaga  ttggcagct  aggatgagc  ggtgttcct  360
atgaaacaa  agtcactcc  tgccaagca  cctgccacg  ccacaagaa  ctccgaatc  420
cctgccaga  gaccctctg  ctctccaag  acgcagggt  ggggtggac  agctagtgt  480
ccaagcgcc  ccccaggaa  atcagtaaa  aagccagat  caaacatca  aaataatgc  540
gcaagtgaa  gggtattgg  cagcttctt  aatagtctg  tgagtaaaa  gacaggctc  600
cctggaagt  ccagtgctg  tggagtgca  agcacagcc  agaagtcag  acaaaagac  660
gtgttgtca  acgttcagg  agaactgga  agaatgact  gaaaaccag  ctccatggt  720
acgaactct  caacagaaa  cgaagcc  747



<210> 132
<211> 249
<212> PRT
<213> Rattus norvegicus
<308> BAA23368
<400> 132

His Asp Tyr Arg Asp Glu His Leu Asp Phe Ile Gln Ala His Leu Arg 
  1               5                  10                  15
Gly Phe Cys Leu Gln Tyr Gly Ala Ala Leu Ile Tyr Thr Ser Val Lys 
             20                  25                  30
Glu Glu Lys Asn Leu Asp Leu Leu Tyr Lys Tyr Ile Val His Lys Thr 
         35                  40                  45
Tyr Gly Phe His Phe Thr Ile Pro Ala Leu Val Val Glu Lys Asp Ala 
     50                  55                  60
Val Phe Ile Pro Ala Gly Trp Asp Asn Glu Lys Lys Ile Ala Ile Leu 
 65                  70                  75                  80
His Glu Asn Phe Thr Thr Val Lys Pro Glu Asp Ala Tyr Glu Asp Phe 
                 85                  90                  95
Ile Val Lys Pro Pro Val Arg Lys Leu Val His Asp Lys Glu Leu Ala 
             100                105                110
Ala Glu Asp Glu Gln Val Phe Leu Met Lys Gln Gln Ser Leu Leu Ala 
         115                120                125
Lys Gln Pro Ala Thr Pro Thr Arg Thr Ser Glu Ser Pro Ala Arg Gly 
     130                135                140
Pro Ser Gly Ser Pro Arg Thr Gln Gly Arg Gly Gly Pro Ala Ser Val 
 145                150                155                160
Pro Ser Ala Ser Pro Gly Thr Ser Val Lys Lys Pro Asp Pro Asn Ile 
                 165                170                175
Lys Asn Asn Ala Ala Ser Glu Gly Val Leu Ala Ser Phe Phe Asn Ser 
             180                185                190
Leu Leu Ser Lys Lys Thr Gly Ser Pro Gly Ser Pro Ser Ala Gly Gly 
         195                200                205
Val Gln Ser Thr Ala Lys Lys Ser Gly Gln Lys Thr Val Leu Ser Asn 
     210                215                220
Val Gln Glu Glu Leu Asp Arg Met Thr Arg Lys Pro Asp Ser Met Val 
 225                230                235                240
Thr Asn Ser Ser Thr Glu Asn Glu Ala 
                 245



<210> 133
<211> 2474
<212> DNA
<213> Homo sapiens
<308> XM_003119
<400> 133

gttcccgcc  cctccaccg  caccgcctc  gccgcctcg  acatttagt  ttgccggga  60
tggtgtgat  cccgaccaa  atggcggcc  tggggcgag  cggctcctt  ggttcttct  120
cgccgggat  atcctcgac  tacactggc  gccccttgg  caacgagat  gcgtcgggc  180
acggtggcg  cgcggcagg  gacgacgag  acgggcaga  cctttggtc  tgcatcctc  240
gcgaggtct  cacccgctc  cgctccaag  tccctgcgg  gaagaacgt  ctactgctg  300
gtgaagatg  agctggaaa  acaagctta  taagaaaaa  tcagggaat  gaggagtat  360
agaaaggaa  aggattgga  tatttgtac  taaatgtgc  tgatgaaga  agggatgat  420
aaacaagat  taatgtttg  atcttagat  gagacctat  tcacaaagg  ctccttaaa  480
tttcactgg  tgccgtatc  ctgaaggat  ctctagtta  gctggttgt  gacatgtca  540
agccttgga  tgctttgga  tctttacag  aatgggcaa  tgttgttag  gaacatgtt  600
acaaactga  aatccctcc  gaagaaatg  aacaaatgg  acaaaagtt  attagagac  660
tccaagaat  tgtagagcc  ggagaagac  tcccggctt  tccccagag  agaaatact  720
cgtcacaag  agacaaaga  gacagtgta  ttttacctc  gggtgcgga  acacttaca  780
ataacttgg  cattccagt  ctagtagtt  gcacaaagt  tgatgccat  agtgtattg  840
agaaagaac  tgactacag  gatgaacat  ttgatttta  tcagtcaca  atccggaag  900
tttgtttac  gtatggtgc  gcacttatt  acacttcag  aaaagaaaa  aaaaatata  960
acttagtat  taaatacat  gttcagaaa  tatatggat  tccctataa  attcctgct  1020
ttgttgtgg  aaaggatgc  gtatttatt  cagcagggt  ggataatga  aagaaaata  1080
gaatattac  tgaaaattt  caaacatta  aagcagaag  taattttga  gacatcata  1140
ctaaaccac  tgttcgaaa  tttgtacat  agaaggaaa  tatggcaga  gatgatcag  1200
tgtttctta  gaagctaca  tccctttta  caaagcaac  accaactgc  gctggaagg  1260
ctgtggatg  ctcaccaag  gtcccagga  gctccccac  aacaccaaa  agatctgta  1320
catctaatg  tgccagcgt  tcacccatt  ctgctgggt  aaaaaaaat  gatccaaac  1380
tgaaagctg  agctacaag  gaaggcgtt  tggcaaatt  cttcaacag  ttgttgagt  1440
aaaagactg  ctctccagg  ggccctggt  tgagtggtg  tagccctgc  ggtggggct  1500
gaggtggaa  cagtggttt  ccaccatcc  ccaaaaagt  aggccagaa  cctgtctta  1560
atgttcatg  agaactaga  agaattaca  gaaaaccag  tacagtttc  cccacaaca  1620
ctacatctc  tacggaagg  gaagcttct  gaagatacc  aataaagcc  tttattctg  1680
tttctggga  aatgtaaac  tgcctctgc  ttttccttc  aaagtggaa  tagaaagct  1740
gagtgcttc  tcagatgga  taaatttat  tcgtgtgtg  gtgtgtgtg  gtgtgtggt  1800
acccatttt  tagaaggag  cgtacagaa  aaaaattat  ctacattat  taggattgc  1860
gtttgcatt  ccattttgc  taagaaagt  atttttgat  ttgaaaatc  caaaacttt  1920
agatctgaa  tacagccat  tgatcgatc  tattctaaa  gctatttaa  acatgtaaa  1980
ggatttggg  aacggcaga  aacatgcag  ttgggcatt  gactgactt  gaagtctaa  2040
cttatttta  ttataacta  taaaatcat  tttaaaaat  tgttagttt  gctgacaga  2100
aaaaatcgt  agttgtcag  ttttgcaca  cacaataaa  gtaccacca  acacggaat  2160
tgctaagaa  actatcaga  agcgtttga  acactagtc  ttgtctcaa  cactgatcc  2220
gtaagttgt  atcaaaata  gatttagaa  tattggcca  ggtgttgct  taactgagg  2280
gaaaagaaa  cacactgcc  aaatgtgta  aagaaaaat  cagaggtta  taaaatgta  2340
agaagtaac  atctttgga  ttgtctata  atatatata  atatatatg  ctttgcctt  2400
atatacccc  ttttttgtt  gtgactttc  actgtaatc  gttaataaa  tatttattc  2460
ctgcattca  gttc  2474



<210> 134
<211> 523
<212> PRT
<213> Homo sapiens
<308> XP_003119
<400> 134

Met Ala Ala Val Gly Arg Val Gly Ser Phe Gly Ser Ser Pro Pro Gly 
  1               5                  10                  15
Leu Ser Ser Thr Tyr Thr Gly Gly Pro Leu Gly Asn Glu Ile Ala Ser 
             20                  25                  30
Gly Asn Gly Gly Ala Ala Ala Gly Asp Asp Glu Asp Gly Gln Asn Leu 
         35                  40                  45
Trp Ser Cys Ile Leu Ser Glu Val Ser Thr Arg Ser Arg Ser Lys Leu 
     50                  55                  60
Pro Ala Gly Lys Asn Val Leu Leu Leu Gly Glu Asp Gly Ala Gly Lys 
 65                  70                  75                  80
Thr Ser Leu Ile Arg Lys Ile Gln Gly Ile Glu Glu Tyr Lys Lys Gly 
                 85                  90                  95
Arg Gly Leu Glu Tyr Leu Tyr Leu Asn Val His Asp Glu Asp Arg Asp 
             100                105                110
Asp Gln Thr Arg Cys Asn Val Trp Ile Leu Asp Gly Asp Leu Tyr His 
         115                120                125
Lys Gly Leu Leu Lys Phe Ser Leu Asp Ala Val Ser Leu Lys Asp Thr 
     130                135                140
Leu Val Met Leu Val Val Asp Met Ser Lys Pro Trp Thr Ala Leu Asp 
 145                150                155                160
Ser Leu Gln Lys Trp Ala Ser Val Val Arg Glu His Val Asp Lys Leu 
                 165                170                175
Lys Ile Pro Pro Glu Glu Met Lys Gln Met Glu Gln Lys Leu Ile Arg 
             180                185                190
Asp Phe Gln Glu Tyr Val Glu Pro Gly Glu Asp Phe Pro Ala Ser Pro 
         195                200                205
Gln Arg Arg Asn Thr Ala Ser Gln Glu Asp Lys Asp Asp Ser Val Val 
     210                215                220
Leu Pro Leu Gly Ala Asp Thr Leu Thr His Asn Leu Gly Ile Pro Val 
 225                230                235                240
Leu Val Val Cys Thr Lys Cys Asp Ala Ile Ser Val Leu Glu Lys Glu 
                 245                250                255
His Asp Tyr Arg Asp Glu His Phe Asp Phe Ile Gln Ser His Ile Arg 
             260                265                270
Lys Phe Cys Leu Gln Tyr Gly Ala Ala Leu Ile Tyr Thr Ser Val Lys 
         275                280                285
Glu Asn Lys Asn Ile Asp Leu Val Tyr Lys Tyr Ile Val Gln Lys Leu 
     290                295                300
Tyr Gly Phe Pro Tyr Lys Ile Pro Ala Val Val Val Glu Lys Asp Ala 
 305                310                315                320
Val Phe Ile Pro Ala Gly Trp Asp Asn Asp Lys Lys Ile Gly Ile Leu 
                 325                330                335
His Glu Asn Phe Gln Thr Leu Lys Ala Glu Asp Asn Phe Glu Asp Ile 
             340                345                350
Ile Thr Lys Pro Pro Val Arg Lys Phe Val His Glu Lys Glu Ile Met 
         355                360                365
Ala Glu Asp Asp Gln Val Phe Leu Met Lys Leu Gln Ser Leu Leu Ala 
     370                375                380
Lys Gln Pro Pro Thr Ala Ala Gly Arg Pro Val Asp Ala Ser Pro Arg 
 385                390                395                400
Val Pro Gly Gly Ser Pro Arg Thr Pro Asn Arg Ser Val Ser Ser Asn 
                 405                410                415
Val Ala Ser Val Ser Pro Ile Pro Ala Gly Ser Lys Lys Ile Asp Pro 
             420                425                430
Asn Met Lys Ala Gly Ala Thr Ser Glu Gly Val Leu Ala Asn Phe Phe 
         435                440                445
Asn Ser Leu Leu Ser Lys Lys Thr Gly Ser Pro Gly Gly Pro Gly Val 
     450                455                460
Ser Gly Gly Ser Pro Ala Gly Gly Ala Gly Gly Gly Ser Ser Gly Leu 
 465                470                475                480
Pro Pro Ser Thr Lys Lys Ser Gly Gln Lys Pro Val Leu Asp Val His 
                 485                490                495
Ala Glu Leu Asp Arg Ile Thr Arg Lys Pro Val Thr Val Ser Pro Thr 
             500                505                510
Thr Pro Thr Ser Pro Thr Glu Gly Glu Ala Ser 
         515                520



<210> 135
<211> 2866
<212> DNA
<213> Rattus norvegicus
<308> AB008538
<400> 135

gtggaggaa  gttgcgtgt  gcacagacc  gacggcgca  cgccacagc  accggggga  60
cgtgtgtct  ggaaaaaaa  gtcgctgtc  ccctaagcg  gacccacaa  cgagcgggc  120
ccgtgggcc  ggggacgac  ccccctctg  ggcgtggac  ttgtcggtg  ccttctagg  180
ggaggaata  ggcatctaa  gggtcccct  cttgccgtc  ggttttctg  ctcttgatc  240
ccgccgcgg  cctcagacc  ggcctcgga  ggtacactg  caactcagc  tacggagat  300
ccattgtca  gccttgcag  ctggatgta  ctcagaacc  catgtttgg  aaatggaaa  360
atgaaaagc  tgatgggtc  ccagtattt  ttgcattca  atcttctac  aagaaaagt  420
tgcagtatg  tgatgtacc  gagtacaag  acagactga  cctctcaga  aactacact  480
tgtctatca  caatgcaaa  atcagtgac  aaaagagat  tgtgtgcat  ctagtgacc  540
aggacaacg  gtttgaggc  cctaccctg  tcaaggtgt  caagcaacc  tctaaacct  600
aaattgtaa  cagagcagc  tttcttgaa  cagagcagc  aaaaaagtt  ggtgactgc  660
tttcaagag  cagttaccc  gacggcaac  tcacgtggt  taggaatgg  aaagtgcta  720
agcctgttg  tggagaggt  tccatactt  ttaaaaagg  aattgatcc  ggtactcag  780
tgtatacca  gacttcctc  ttggagtac  agacaacca  gtctgacat  caaatgcca  840
tcacctgtt  tgtgacata  tatggacct  cgggccaga  aacaattta  tctgaacaa  900
caatctttg  tatttacta  cctacagag  aggtgacaa  acaagtact  ccaccaaaa  960
atgccatca  agaagggga  aacatcacc  ttcagtgct  ggggaatgg  aacccacct  1020
ctgaggagt  catgtttta  ttaccaggg  aggctgaag  cataagaag  tcaaacact  1080
acacactga  agacgtgag  cgcaatgcc  ccggggact  caaatgttc  ctcatcgac  1140
aaagaaaca  ggcagcttc  acaaccatc  ctgttcact  cttggattt  tccttaaac  1200
caagtgggg  agtgaccaa  cagatcggt  ataccctgc  tgtgtcttg  acaatatct  1260
caagtagga  tgcaactgt  gtgtggatg  aggataaca  caggctccg  tctagtcca  1320
ccttttcta  tcttcatta  caggatgct  ggaactatg  ctgtgaaac  gctcttcag  1380
aggttgagg  actgaagaa  agggagtcg  tgaccctca  cgtagaagg  aaacctcaa  1440
tcaaaatga  aaagaaaac  gatcccagt  gactgtcta  gactataat  tgccatgtg  1500
aagggtttc  aaagccagc  atacagtgg  ccattaccg  cagtggaag  gtcataaac  1560
aaacagagg  gtctcctta  attaatggc  ggtattata  taaaattat  atttcccct  1620
aggagaatg  tacattaac  tgcacagca  aaaaccaac  ggagagaac  gtaaactcc  1680
tgaatgtct  tgcgataag  attccagaa  acgatgagg  agacgatat  agtgatgaa  1740
acagagaaa  ggtgaatga  caggccaaa  taattgtgg  cattgtggt  ggtctcctc  1800
tcgccgccc  cgtcgccgg  gtcgtctac  ggctgtaca  gaagaaatc  aaaactgca  1860
caaaacatg  aaacaagga  cttggtaat  tggaggaga  taaaaagct  gaagaaaac  1920
atcacaaaa  agaagccta  gagaggagt  gtttagatg  cctgagaaa  aaacatata  1980
agaaattga  gcatgaacg  gattgtatt  aagacatat  caaagacaa  gacagcaat  2040
catggttca  gtattaaga  gttcatcct  ctaagctgt  ctgggatct  agagaatta  2100
ctcaagtaa  acaatgaaa  aaagttata  aattacaac  agatttggc  gccatgata  2160
taggtcata  gttgtattt  gtttgattt  ccttttctg  aaatgtctg  actgaggat  2220
tctttcagt  tgcctttta  gtaaatttt  tacgtagct  tttttatac  ctgtaagct  2280
tgttctggg  gtggctgtt  attggatgt  caatgtaat  tttatttca  ttgtttata  2340
ggatagtct  agcaggtgc  gttctgatt  tgattgcta  cagtaatgc  ccaaacttt  2400
ttgtgagga  ctgaaaccc  aaggtggca  ttatgagat  gggacatgg  tcttgccca  2460
tcagaagct  gtttttttt  taaaaaaaa  aacctggag  gtcaggagc  ccataagat  2520
tgatggtct  tatgtgcca  cgggttccc  gaagcgggt  acaaacaca  acggcaaca  2580
cacatgtga  tgatacttt  aaactgaca  tttcgtctt  tctgaaaaa  gacatacac  2640
gagtttgta  aacacttta  ttaacgaca  ttgctagaa  attacattc  gtttttaaa  2700
aaaataagg  aaatgtaaa  aagaatatc  aatatgtca  agaaagttg  aaacaaatc  2760
cagctcgca  ccccatagt  gcagatcac  atgtaaatc  ctgtaatta  aattggtgt  2820
aaatccttt  ggttatcca  tgccttaaa  tgacactta  ttcctt  2866



<210> 136
<211> 583
<212> PRT
<213> Rattus norvegicus
<308> BAA23279
<400> 136

Met Ala Ser Lys Gly Ser Pro Ser Cys Arg Leu Val Phe Cys Leu Leu 
  1               5                  10                  15
Ile Ser Ala Ala Val Leu Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 
             20                  25                  30
Ser Ala Tyr Gly Asp Thr Ile Val Met Pro Cys Arg Leu Asp Val Pro 
         35                  40                  45
Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
     50                  55                  60
Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 
 65                  70                  75                  80
Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Ser Leu Ser Glu Asn Tyr 
                 85                  90                  95
Thr Leu Ser Ile Asn Asn Ala Lys Ile Ser Asp Glu Lys Arg Phe Val 
             100                105                110
Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Leu Val 
         115                120                125
Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Asn Arg Ala Ala 
     130                135                140
Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Arg 
 145                150                155                160
Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val 
                 165                170                175
Leu Gln Pro Val Asp Gly Glu Val Ser Ile Leu Phe Lys Lys Glu Ile 
             180                185                190
Asp Pro Gly Thr Gln Leu Tyr Thr Met Thr Ser Ser Leu Glu Tyr Lys 
         195                200                205
Thr Thr Lys Ser Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr 
     210                215                220
Tyr Gly Pro Ser Gly Gln Lys Thr Ile Tyr Ser Glu Gln Ala Ile Phe 
 225                230                235                240
Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro 
                 245                250                255
Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Gln Cys Leu Gly 
             260                265                270
Asn Gly Asn Pro Pro Pro Glu Glu Phe Met Phe Tyr Leu Pro Gly Gln 
         275                280                285
Ala Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg 
     290                295                300
Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Gln Arg Asn 
 305                310                315                320
Met Ala Ala Ser Thr Thr Ile Thr Val His Tyr Leu Asp Leu Ser Leu 
                 325                330                335
Asn Pro Ser Gly Glu Val Thr Lys Gln Ile Gly Asp Thr Leu Pro Val 
             340                345                350
Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys 
         355                360                365
Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
     370                375                380
Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu 
 385                390                395                400
Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro 
                 405                410                415
Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr 
             420                425                430
Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr 
         435                440                445
Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr 
     450                455                460
Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
 465                470                475                480
Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn 
                 485                490                495
Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp 
             500                505                510
Asp Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu 
         515                520                525
Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly 
     530                535                540
Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His 
 545                550                555                560
Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu 
                 565                570                575
Asn Asn His Lys Thr Glu Ala 
             580



<210> 137
<211> 2539
<212> DNA
<213> Homo sapiens
<308> NM_001627
<400> 137

cgggacgac  ccccctcct  cggcgtgga  tccgtcagt  gcccaccaa  aaggaggag  60
aatatggaa  ccaaggggg  cagttcctg  cgtctgctc  tctgcctct  gatctccgc  120
accgtcttc  ggccaggcc  tggatggta  actgtaaat  cagcatatg  agataccat  180
atcatacct  gccgacttg  cgtacctca  aatctcatg  ttggcaaat  gaaatatga  240
aagcccgat  gctccccag  atttattgc  ttcagatcc  ctacaaaga  aagtgtgca  300
tacgacgat  taccagaat  caaagacag  ttgaacctc  cagaaaact  cactttgtc  360
atcagtaat  caaggatca  tgatgaaaa  agatttgtg  gcatgctag  aactgagga  420
aacgtgttt  aggcaccta  aatagtcaa  gtgttcaag  aaccatcta  acctgaaat  480
gtaagcaaa  cactgtttc  cgaaacaga  cagctaaaa  agttgggtg  ctgcatttc  540
gaagacagt  atccagatg  caatatcac  tggtacagg  atggaaaag  gctacatcc  600
cttgaagga  cggtggtca  aatttttaa  aaggaaatg  acccagtga  tcagctcta  660
accatgact  ccaccctgg  gtacaagac  accaaggct  acatacaaa  gccattcac  720
tgctcggtg  catattatg  accatctgg  cagaaaaca  ttcattctg  acaggcagt  780
tttgatatt  actatccta  agagcaggt  acaatacaa  tgctgccac  aaaaaatgc  840
atcaaagaa  gggataaca  cactcttaa  tgcttaggg  atggcaacc  tcccccaga  900
gaatttttg  tttacttac  aggacagcc  gaaggaata  gaagctcaa  tacttacac  960
ctgatggat  tgaggcgca  tgcaacagg  gactacaag  gttccctga  agacaaaaa  1020
agcatgatt  cttcaacag  catcacagt  cactatttg  atttgtcct  aaacccaag  1080
ggagaagtg  ctagacaga  tggtgatgc  ctacccgtg  catgcacaa  atctgctag  1140
aggaatgca  ctgtggtat  gatgaaaga  aacatcagg  ttcgatcta  cccgtcatt  1200
tctagtctt  attatcagg  tgctggaaa  tatgtctgc  aaactgctc  gcaggaggt  1260
gaaggacta  agaaaagag  gtcattgac  ctcattgta  aaggcaaac  tcaaataaa  1320
atgacaaag  aaactgatc  cagtggact  tctaaaaca  taatctgcc  tgtggaagg  1380
tttccaaag  cagccattc  gtggacaat  actggcagt  gaagcgtca  aaaccaaac  1440
gaggaatct  cttatatta  tggcaggta  tatagtaaa  ttatcattt  ccctgaaga  1500
aatgttaca  taacttgca  agcagaaaa  caactggag  gaacagtaa  ctccttgaa  1560
gtctctgct  taagtattc  agaacacga  gaggcagac  agataagtg  tgaaaacag  1620
gaaaaggtg  atgaccagg  aaaactaat  gtgggaatc  ttgttggtc  cctccttgc  1680
gcccttgtt  ctggtgtcg  ctactggct  tacatgaag  agtcaaaga  tgcatcaaa  1740
catgtaaac  aggacctcg  taatatgga  gaaaacaaa  agttagaag  aaacaatca  1800
aaaactgaa  cctaagaga  aaactgtcc  agttgtcca  agataaaaa  catatagac  1860
aattgaagc  tgaacgtgg  ttgtattta  gacataaac  aagacattg  cagcaattc  1920
tggttcaag  attaagcag  tcattctac  aagctgtca  aggttttca  agaattatc  1980
caagtaaaa  aaatgaaat  taattacaa  caataagaa  aagttttgg  agccatgat  2040
ataggtcat  tgttgtgtt  ggttcaatt  tttttccgt  aatgtctgc  ctgaggatt  2100
ctttttggt  tgcctttta  gtaaatttt  tacgtagct  tttttatac  ctgtaagct  2160
tgttctggg  gttgctgtt  atctgatgt  taatgtaat  tttttattt  aattgttta  2220
atggataat  tgagcaggt  catttctga  tctgattgc  atcagcaat  ccccaaact  2280
tctcataag  acctaaaac  caaaggtgg  agcttgtga  gattgggga  actcatatt  2340
ccctaatta  aaactgtga  ttttatcac  agggagggg  ggccgagag  cagactgat  2400
gacaccata  gagccgact  tttgatatg  caccagcga  ctctcagaa  taaatcaca  2460
atgcatata  acacacata  ataatggta  tcccaaact  acaatttta  ctattctga  2520
aaagacata  aacagaatt  2539



<210> 138
<211> 583
<212> PRT
<213> Homo sapiens
<308> Q13740
<400> 138

Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 
  1               5                  10                  15
Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 
             20                  25                  30
Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 
         35                  40                  45
Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
     50                  55                  60
Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 
 65                  70                  75                  80
Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 
                 85                  90                  95
Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 
             100                105                110
Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val 
         115                120                125
Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu 
     130                135                140
Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu 
 145                150                155                160
Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val 
                 165                170                175
Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met 
             180                185                190
Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys 
         195                200                205
Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr 
     210                215                220
Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe 
 225                230                235                240
Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro 
                 245                250                255
Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly 
             260                265                270
Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln 
         275                280                285
Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Met Asp Val Arg 
     290                295                300
Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser 
 305                310                315                320
Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu 
                 325                330                335
Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val 
             340                345                350
Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys 
         355                360                365
Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
     370                375                380
Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu 
 385                390                395                400
Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro 
                 405                410                415
Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr 
             420                425                430
Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr 
         435                440                445
Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr 
     450                455                460
Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
 465                470                475                480
Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn 
                 485                490                495
Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp 
             500                505                510
Glu Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu 
         515                520                525
Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly 
     530                535                540
Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His 
 545                550                555                560
Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu 
                 565                570                575
Asn Asn His Lys Thr Glu Ala 
             580



<210> 139
<211> 859
<212> DNA
<213> Rattus norvegicus
<308> AB008807
<400> 139

tgcttcctg  gtcacccgc  aacgagagc  ggaccctct  ggctctccg  ctgctcggc  60
cagcgatgt  cggggcgtc  gccaggagc  tggggaagg  aagcgcgcc  cctggcccg  120
tcccggagg  cagatccga  tctacagca  gaggttctg  ccctttgct  agaggacgc  180
gatggtcct  aaggccaag  gaatccggc  tgaaatcat  aacatcaac  tgaagaata  240
gcccgagtg  ttctttgag  agaatccct  tgggctggt  ccggttctg  agaacactc  300
gggtcactt  atcactgaa  ctgtcatca  ttgcgagta  ctggatgaa  catacccgg  360
gaagaagtt  ttcccagat  acccgtacg  gaaagcttg  cagaagatg  cctttgagt  420
attctcaaa  gtgccgtct  tggttacga  ttttattag  gcgaagaga  aggaagacc  480
tccgggcat  aaggaagaa  tgaagaaag  gttcagcaa  ctagaagag  ctatggcta  540
taagaggac  gccttcttc  gtgggaatt  gctctcaat  atcgattat  ttatttggc  600
gtggtttca  cgactggaa  cactggagc  caatgagtg  atagaccac  ccccaaaac  660
caagctctg  atggcaacc  tgcaggaag  ccctgtggc  tcatcccac  tcattgatg  720
caagaccta  cgtgattac  taagtctct  cctacagga  agccccgag  cctgtgatt  780
tgggctctg  ggggcaaga  ccctcagcg  atgatgttt  ccttcatcg  ttgaatagc  840
tgcttttat  ttacccatt  859



<210> 140
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> BAA34217
<400> 140

Met Ser Gly Ala Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro 
  1               5                  10                  15
Gly Pro Val Pro Glu Gly Gln Ile Arg Val Tyr Ser Met Arg Phe Cys 
             20                  25                  30
Pro Phe Ala Gln Arg Thr Leu Met Val Leu Lys Ala Lys Gly Ile Arg 
         35                  40                  45
His Glu Ile Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe 
     50                  55                  60
Glu Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Thr Gln Gly 
 65                  70                  75                  80
His Leu Ile Thr Glu Ser Val Ile Thr Cys Glu Tyr Leu Asp Glu Ala 
                 85                  90                  95
Tyr Pro Glu Lys Lys Leu Phe Pro Asp Asp Pro Tyr Glu Lys Ala Cys 
             100                105                110
Gln Lys Met Thr Phe Glu Leu Phe Ser Lys Val Pro Ser Leu Val Thr 
         115                120                125
Ser Phe Ile Arg Ala Lys Arg Lys Glu Asp His Pro Gly Ile Lys Glu 
     130                135                140
Glu Leu Lys Lys Glu Phe Ser Lys Leu Glu Glu Ala Met Ala Asn Lys 
 145                150                155                160
Arg Thr Ala Phe Phe Gly Gly Asn Ser Leu Ser Met Ile Asp Tyr Leu 
                 165                170                175
Ile Trp Pro Trp Phe Gln Arg Leu Glu Ala Leu Glu Leu Asn Glu Cys 
             180                185                190
Ile Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Thr Met Gln Glu 
         195                200                205
Asp Pro Val Ala Ser Ser His Phe Ile Asp Ala Lys Thr Tyr Arg Asp 
     210                215                220
Tyr Leu Ser Leu Tyr Leu Gln Asp Ser Pro Glu Ala Cys Asp Tyr Gly 
 225                230                235                240
Leu 
                 245



<210> 141
<211> 793
<212> DNA
<213> Homo sapiens
<308> NM_004832
<400> 141

tgcgccacg  tgtccgggg  gtcagccag  agcttgggg  agggaagcg  gcccccggg  60
ccggtcccg  agggctcga  ccgcatcta  agcatgagg  tctgcccgt  tgctgagag  120
acgcgtcta  tcctgaagg  caagggaat  aggcatgaa  tcatcaata  caacctgaa  180
aataagcct  agtggttct  taagaaaaa  ccctttggt  tggtgccag  tctggaaaa  240
agtcagggt  agctgatct  cgagtctgc  atcacctgt  agtacctgg  tgaagcata  300
ccagggaag  agctgttgc  ggatgaccc  tatgagaaa  cttgccaga  gatgatctt  360
gagttgttt  ctaaggtgc  atccttggt  ggaagcttt  ttagaagcc  aaataaaga  420
gactatgct  gcctaaaag  agaatttcg  aaagaattt  ccaagctag  ggaggttct  480
actaataag  agacgacct  ctttggtgg  aattctatc  ctatgattg  ttacctcat  540
tggccctgg  ttgaacggc  ggaagcaat  aagttaaat  agtgtgtag  ccacactcc  600
aaactgaaa  tgtggatgg  agccatgaa  gaagatccc  cagtctcag  cctgcttac  660
agtgagaaa  actggcaag  tttcctaga  ctctactta  agaacagcc  tgaggcctg  720
gactatggg  tctgaaggg  gcaggagtc  gcaataaag  tatgtctga  attttcctt  780
agtaaaaaa  aaa  793



<210> 142
<211> 241
<212> PRT
<213> Homo sapiens
<308> P78417
<400> 142

Met Ser Gly Glu Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro 
  1               5                  10                  15
Gly Pro Val Pro Glu Gly Ser Ile Arg Ile Tyr Ser Met Arg Phe Cys 
             20                  25                  30
Pro Phe Ala Glu Arg Thr Arg Leu Val Leu Lys Ala Lys Gly Ile Arg 
         35                  40                  45
His Glu Val Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe 
     50                  55                  60
Lys Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Ser Gln Gly 
 65                  70                  75                  80
Gln Leu Ile Tyr Glu Ser Ala Ile Thr Cys Glu Tyr Leu Asp Glu Ala 
                 85                  90                  95
Tyr Pro Gly Lys Lys Leu Leu Pro Asp Asp Pro Tyr Glu Lys Ala Cys 
             100                105                110
Gln Lys Met Ile Leu Glu Leu Phe Ser Lys Val Pro Ser Leu Val Gly 
         115                120                125
Ser Phe Ile Arg Ser Gln Asn Lys Glu Asp Tyr Ala Gly Leu Lys Glu 
     130                135                140
Glu Phe Arg Lys Glu Phe Thr Lys Leu Glu Glu Val Leu Thr Asn Lys 
 145                150                155                160
Lys Thr Thr Phe Phe Gly Gly Asn Ser Ile Ser Met Ile Asp Tyr Leu 
                 165                170                175
Ile Trp Pro Trp Phe Glu Arg Leu Glu Ala Met Lys Leu Asn Glu Cys 
             180                185                190
Val Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Ala Met Lys Glu 
         195                200                205
Asp Pro Thr Val Ser Ala Leu Leu Thr Ser Glu Lys Asp Trp Gln Gly 
     210                215                220
Phe Leu Glu Leu Tyr Leu Gln Asn Ser Pro Glu Ala Cys Asp Tyr Gly 
 225                230                235                240
Leu 
                 245



<210> 143
<211> 859
<212> DNA
<213> Rattus norvegicus
<308> AB008807
<400> 143

tgcttcctg  gtcacccgc  aacgagagc  ggaccctct  ggctctccg  ctgctcggc  60
cagcgatgt  cggggcgtc  gccaggagc  tggggaagg  aagcgcgcc  cctggcccg  120
tcccggagg  cagatccga  tctacagca  gaggttctg  ccctttgct  agaggacgc  180
gatggtcct  aaggccaag  gaatccggc  tgaaatcat  aacatcaac  tgaagaata  240
gcccgagtg  ttctttgag  agaatccct  tgggctggt  ccggttctg  agaacactc  300
gggtcactt  atcactgaa  ctgtcatca  ttgcgagta  ctggatgaa  catacccgg  360
gaagaagtt  ttcccagat  acccgtacg  gaaagcttg  cagaagatg  cctttgagt  420
attctcaaa  gtgccgtct  tggttacga  ttttattag  gcgaagaga  aggaagacc  480
tccgggcat  aaggaagaa  tgaagaaag  gttcagcaa  ctagaagag  ctatggcta  540
taagaggac  gccttcttc  gtgggaatt  gctctcaat  atcgattat  ttatttggc  600
gtggtttca  cgactggaa  cactggagc  caatgagtg  atagaccac  ccccaaaac  660
caagctctg  atggcaacc  tgcaggaag  ccctgtggc  tcatcccac  tcattgatg  720
caagaccta  cgtgattac  taagtctct  cctacagga  agccccgag  cctgtgatt  780
tgggctctg  ggggcaaga  ccctcagcg  atgatgttt  ccttcatcg  ttgaatagc  840
tgcttttat  ttacccatt  859



<210> 144
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> BAA34217
<400> 144

Met Ser Gly Ala Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro 
  1               5                  10                  15
Gly Pro Val Pro Glu Gly Gln Ile Arg Val Tyr Ser Met Arg Phe Cys 
             20                  25                  30
Pro Phe Ala Gln Arg Thr Leu Met Val Leu Lys Ala Lys Gly Ile Arg 
         35                  40                  45
His Glu Ile Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe 
     50                  55                  60
Glu Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Thr Gln Gly 
 65                  70                  75                  80
His Leu Ile Thr Glu Ser Val Ile Thr Cys Glu Tyr Leu Asp Glu Ala 
                 85                  90                  95
Tyr Pro Glu Lys Lys Leu Phe Pro Asp Asp Pro Tyr Glu Lys Ala Cys 
             100                105                110
Gln Lys Met Thr Phe Glu Leu Phe Ser Lys Val Pro Ser Leu Val Thr 
         115                120                125
Ser Phe Ile Arg Ala Lys Arg Lys Glu Asp His Pro Gly Ile Lys Glu 
     130                135                140
Glu Leu Lys Lys Glu Phe Ser Lys Leu Glu Glu Ala Met Ala Asn Lys 
 145                150                155                160
Arg Thr Ala Phe Phe Gly Gly Asn Ser Leu Ser Met Ile Asp Tyr Leu 
                 165                170                175
Ile Trp Pro Trp Phe Gln Arg Leu Glu Ala Leu Glu Leu Asn Glu Cys 
             180                185                190
Ile Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Thr Met Gln Glu 
         195                200                205
Asp Pro Val Ala Ser Ser His Phe Ile Asp Ala Lys Thr Tyr Arg Asp 
     210                215                220
Tyr Leu Ser Leu Tyr Leu Gln Asp Ser Pro Glu Ala Cys Asp Tyr Gly 
 225                230                235                240
Leu 
                 245



<210> 145
<211> 793
<212> DNA
<213> Homo sapiens
<308> NM_004832
<400> 145

tgcgccacg  tgtccgggg  gtcagccag  agcttgggg  agggaagcg  gcccccggg  60
ccggtcccg  agggctcga  ccgcatcta  agcatgagg  tctgcccgt  tgctgagag  120
acgcgtcta  tcctgaagg  caagggaat  aggcatgaa  tcatcaata  caacctgaa  180
aataagcct  agtggttct  taagaaaaa  ccctttggt  tggtgccag  tctggaaaa  240
agtcagggt  agctgatct  cgagtctgc  atcacctgt  agtacctgg  tgaagcata  300
ccagggaag  agctgttgc  ggatgaccc  tatgagaaa  cttgccaga  gatgatctt  360
gagttgttt  ctaaggtgc  atccttggt  ggaagcttt  ttagaagcc  aaataaaga  420
gactatgct  gcctaaaag  agaatttcg  aaagaattt  ccaagctag  ggaggttct  480
actaataag  agacgacct  ctttggtgg  aattctatc  ctatgattg  ttacctcat  540
tggccctgg  ttgaacggc  ggaagcaat  aagttaaat  agtgtgtag  ccacactcc  600
aaactgaaa  tgtggatgg  agccatgaa  gaagatccc  cagtctcag  cctgcttac  660
agtgagaaa  actggcaag  tttcctaga  ctctactta  agaacagcc  tgaggcctg  720
gactatggg  tctgaaggg  gcaggagtc  gcaataaag  tatgtctga  attttcctt  780
agtaaaaaa  aaa  793



<210> 146
<211> 241
<212> PRT
<213> Homo sapiens
<308> P78417
<400> 146

Met Ser Gly Glu Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro 
  1               5                  10                  15
Gly Pro Val Pro Glu Gly Ser Ile Arg Ile Tyr Ser Met Arg Phe Cys 
             20                  25                  30
Pro Phe Ala Glu Arg Thr Arg Leu Val Leu Lys Ala Lys Gly Ile Arg 
         35                  40                  45
His Glu Val Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe 
     50                  55                  60
Lys Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Ser Gln Gly 
 65                  70                  75                  80
Gln Leu Ile Tyr Glu Ser Ala Ile Thr Cys Glu Tyr Leu Asp Glu Ala 
                 85                  90                  95
Tyr Pro Gly Lys Lys Leu Leu Pro Asp Asp Pro Tyr Glu Lys Ala Cys 
             100                105                110
Gln Lys Met Ile Leu Glu Leu Phe Ser Lys Val Pro Ser Leu Val Gly 
         115                120                125
Ser Phe Ile Arg Ser Gln Asn Lys Glu Asp Tyr Ala Gly Leu Lys Glu 
     130                135                140
Glu Phe Arg Lys Glu Phe Thr Lys Leu Glu Glu Val Leu Thr Asn Lys 
 145                150                155                160
Lys Thr Thr Phe Phe Gly Gly Asn Ser Ile Ser Met Ile Asp Tyr Leu 
                 165                170                175
Ile Trp Pro Trp Phe Glu Arg Leu Glu Ala Met Lys Leu Asn Glu Cys 
             180                185                190
Val Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Ala Met Lys Glu 
         195                200                205
Asp Pro Thr Val Ser Ala Leu Leu Thr Ser Glu Lys Asp Trp Gln Gly 
     210                215                220
Phe Leu Glu Leu Tyr Leu Gln Asn Ser Pro Glu Ala Cys Asp Tyr Gly 
 225                230                235                240
Leu 
                 245



<210> 147
<211> 859
<212> DNA
<213> Rattus norvegicus
<308> AB008807
<400> 147

tgcttcctg  gtcacccgc  aacgagagc  ggaccctct  ggctctccg  ctgctcggc  60
cagcgatgt  cggggcgtc  gccaggagc  tggggaagg  aagcgcgcc  cctggcccg  120
tcccggagg  cagatccga  tctacagca  gaggttctg  ccctttgct  agaggacgc  180
gatggtcct  aaggccaag  gaatccggc  tgaaatcat  aacatcaac  tgaagaata  240
gcccgagtg  ttctttgag  agaatccct  tgggctggt  ccggttctg  agaacactc  300
gggtcactt  atcactgaa  ctgtcatca  ttgcgagta  ctggatgaa  catacccgg  360
gaagaagtt  ttcccagat  acccgtacg  gaaagcttg  cagaagatg  cctttgagt  420
attctcaaa  gtgccgtct  tggttacga  ttttattag  gcgaagaga  aggaagacc  480
tccgggcat  aaggaagaa  tgaagaaag  gttcagcaa  ctagaagag  ctatggcta  540
taagaggac  gccttcttc  gtgggaatt  gctctcaat  atcgattat  ttatttggc  600
gtggtttca  cgactggaa  cactggagc  caatgagtg  atagaccac  ccccaaaac  660
caagctctg  atggcaacc  tgcaggaag  ccctgtggc  tcatcccac  tcattgatg  720
caagaccta  cgtgattac  taagtctct  cctacagga  agccccgag  cctgtgatt  780
tgggctctg  ggggcaaga  ccctcagcg  atgatgttt  ccttcatcg  ttgaatagc  840
tgcttttat  ttacccatt  859



<210> 148
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> BAA34217
<400> 148

Met Ser Gly Ala Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro 
  1               5                  10                  15
Gly Pro Val Pro Glu Gly Gln Ile Arg Val Tyr Ser Met Arg Phe Cys 
             20                  25                  30
Pro Phe Ala Gln Arg Thr Leu Met Val Leu Lys Ala Lys Gly Ile Arg 
         35                  40                  45
His Glu Ile Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe 
     50                  55                  60
Glu Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Thr Gln Gly 
 65                  70                  75                  80
His Leu Ile Thr Glu Ser Val Ile Thr Cys Glu Tyr Leu Asp Glu Ala 
                 85                  90                  95
Tyr Pro Glu Lys Lys Leu Phe Pro Asp Asp Pro Tyr Glu Lys Ala Cys 
             100                105                110
Gln Lys Met Thr Phe Glu Leu Phe Ser Lys Val Pro Ser Leu Val Thr 
         115                120                125
Ser Phe Ile Arg Ala Lys Arg Lys Glu Asp His Pro Gly Ile Lys Glu 
     130                135                140
Glu Leu Lys Lys Glu Phe Ser Lys Leu Glu Glu Ala Met Ala Asn Lys 
 145                150                155                160
Arg Thr Ala Phe Phe Gly Gly Asn Ser Leu Ser Met Ile Asp Tyr Leu 
                 165                170                175
Ile Trp Pro Trp Phe Gln Arg Leu Glu Ala Leu Glu Leu Asn Glu Cys 
             180                185                190
Ile Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Thr Met Gln Glu 
         195                200                205
Asp Pro Val Ala Ser Ser His Phe Ile Asp Ala Lys Thr Tyr Arg Asp 
     210                215                220
Tyr Leu Ser Leu Tyr Leu Gln Asp Ser Pro Glu Ala Cys Asp Tyr Gly 
 225                230                235                240
Leu 
                 245



<210> 149
<211> 793
<212> DNA
<213> Homo sapiens
<308> NM_004832
<400> 149

tgcgccacg  tgtccgggg  gtcagccag  agcttgggg  agggaagcg  gcccccggg  60
ccggtcccg  agggctcga  ccgcatcta  agcatgagg  tctgcccgt  tgctgagag  120
acgcgtcta  tcctgaagg  caagggaat  aggcatgaa  tcatcaata  caacctgaa  180
aataagcct  agtggttct  taagaaaaa  ccctttggt  tggtgccag  tctggaaaa  240
agtcagggt  agctgatct  cgagtctgc  atcacctgt  agtacctgg  tgaagcata  300
ccagggaag  agctgttgc  ggatgaccc  tatgagaaa  cttgccaga  gatgatctt  360
gagttgttt  ctaaggtgc  atccttggt  ggaagcttt  ttagaagcc  aaataaaga  420
gactatgct  gcctaaaag  agaatttcg  aaagaattt  ccaagctag  ggaggttct  480
actaataag  agacgacct  ctttggtgg  aattctatc  ctatgattg  ttacctcat  540
tggccctgg  ttgaacggc  ggaagcaat  aagttaaat  agtgtgtag  ccacactcc  600
aaactgaaa  tgtggatgg  agccatgaa  gaagatccc  cagtctcag  cctgcttac  660
agtgagaaa  actggcaag  tttcctaga  ctctactta  agaacagcc  tgaggcctg  720
gactatggg  tctgaaggg  gcaggagtc  gcaataaag  tatgtctga  attttcctt  780
agtaaaaaa  aaa  793



<210> 150
<211> 241
<212> PRT
<213> Homo sapiens
<308> P78417
<400> 150

Met Ser Gly Glu Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro 
  1               5                  10                  15
Gly Pro Val Pro Glu Gly Ser Ile Arg Ile Tyr Ser Met Arg Phe Cys 
             20                  25                  30
Pro Phe Ala Glu Arg Thr Arg Leu Val Leu Lys Ala Lys Gly Ile Arg 
         35                  40                  45
His Glu Val Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe 
     50                  55                  60
Lys Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Ser Gln Gly 
 65                  70                  75                  80
Gln Leu Ile Tyr Glu Ser Ala Ile Thr Cys Glu Tyr Leu Asp Glu Ala 
                 85                  90                  95
Tyr Pro Gly Lys Lys Leu Leu Pro Asp Asp Pro Tyr Glu Lys Ala Cys 
             100                105                110
Gln Lys Met Ile Leu Glu Leu Phe Ser Lys Val Pro Ser Leu Val Gly 
         115                120                125
Ser Phe Ile Arg Ser Gln Asn Lys Glu Asp Tyr Ala Gly Leu Lys Glu 
     130                135                140
Glu Phe Arg Lys Glu Phe Thr Lys Leu Glu Glu Val Leu Thr Asn Lys 
 145                150                155                160
Lys Thr Thr Phe Phe Gly Gly Asn Ser Ile Ser Met Ile Asp Tyr Leu 
                 165                170                175
Ile Trp Pro Trp Phe Glu Arg Leu Glu Ala Met Lys Leu Asn Glu Cys 
             180                185                190
Val Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Ala Met Lys Glu 
         195                200                205
Asp Pro Thr Val Ser Ala Leu Leu Thr Ser Glu Lys Asp Trp Gln Gly 
     210                215                220
Phe Leu Glu Leu Tyr Leu Gln Asn Ser Pro Glu Ala Cys Asp Tyr Gly 
 225                230                235                240
Leu 
                 245



<210> 151
<211> 859
<212> DNA
<213> Rattus norvegicus
<308> AB008807
<400> 151

tgcttcctg  gtcacccgc  aacgagagc  ggaccctct  ggctctccg  ctgctcggc  60
cagcgatgt  cggggcgtc  gccaggagc  tggggaagg  aagcgcgcc  cctggcccg  120
tcccggagg  cagatccga  tctacagca  gaggttctg  ccctttgct  agaggacgc  180
gatggtcct  aaggccaag  gaatccggc  tgaaatcat  aacatcaac  tgaagaata  240
gcccgagtg  ttctttgag  agaatccct  tgggctggt  ccggttctg  agaacactc  300
gggtcactt  atcactgaa  ctgtcatca  ttgcgagta  ctggatgaa  catacccgg  360
gaagaagtt  ttcccagat  acccgtacg  gaaagcttg  cagaagatg  cctttgagt  420
attctcaaa  gtgccgtct  tggttacga  ttttattag  gcgaagaga  aggaagacc  480
tccgggcat  aaggaagaa  tgaagaaag  gttcagcaa  ctagaagag  ctatggcta  540
taagaggac  gccttcttc  gtgggaatt  gctctcaat  atcgattat  ttatttggc  600
gtggtttca  cgactggaa  cactggagc  caatgagtg  atagaccac  ccccaaaac  660
caagctctg  atggcaacc  tgcaggaag  ccctgtggc  tcatcccac  tcattgatg  720
caagaccta  cgtgattac  taagtctct  cctacagga  agccccgag  cctgtgatt  780
tgggctctg  ggggcaaga  ccctcagcg  atgatgttt  ccttcatcg  ttgaatagc  840
tgcttttat  ttacccatt  859



<210> 152
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> BAA34217
<400> 152

Met Ser Gly Ala Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro 
  1               5                  10                  15
Gly Pro Val Pro Glu Gly Gln Ile Arg Val Tyr Ser Met Arg Phe Cys 
             20                  25                  30
Pro Phe Ala Gln Arg Thr Leu Met Val Leu Lys Ala Lys Gly Ile Arg 
         35                  40                  45
His Glu Ile Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe 
     50                  55                  60
Glu Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Thr Gln Gly 
 65                  70                  75                  80
His Leu Ile Thr Glu Ser Val Ile Thr Cys Glu Tyr Leu Asp Glu Ala 
                 85                  90                  95
Tyr Pro Glu Lys Lys Leu Phe Pro Asp Asp Pro Tyr Glu Lys Ala Cys 
             100                105                110
Gln Lys Met Thr Phe Glu Leu Phe Ser Lys Val Pro Ser Leu Val Thr 
         115                120                125
Ser Phe Ile Arg Ala Lys Arg Lys Glu Asp His Pro Gly Ile Lys Glu 
     130                135                140
Glu Leu Lys Lys Glu Phe Ser Lys Leu Glu Glu Ala Met Ala Asn Lys 
 145                150                155                160
Arg Thr Ala Phe Phe Gly Gly Asn Ser Leu Ser Met Ile Asp Tyr Leu 
                 165                170                175
Ile Trp Pro Trp Phe Gln Arg Leu Glu Ala Leu Glu Leu Asn Glu Cys 
             180                185                190
Ile Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Thr Met Gln Glu 
         195                200                205
Asp Pro Val Ala Ser Ser His Phe Ile Asp Ala Lys Thr Tyr Arg Asp 
     210                215                220
Tyr Leu Ser Leu Tyr Leu Gln Asp Ser Pro Glu Ala Cys Asp Tyr Gly 
 225                230                235                240
Leu 
                 245



<210> 153
<211> 793
<212> DNA
<213> Homo sapiens
<308> NM_004832
<400> 153

tgcgccacg  tgtccgggg  gtcagccag  agcttgggg  agggaagcg  gcccccggg  60
ccggtcccg  agggctcga  ccgcatcta  agcatgagg  tctgcccgt  tgctgagag  120
acgcgtcta  tcctgaagg  caagggaat  aggcatgaa  tcatcaata  caacctgaa  180
aataagcct  agtggttct  taagaaaaa  ccctttggt  tggtgccag  tctggaaaa  240
agtcagggt  agctgatct  cgagtctgc  atcacctgt  agtacctgg  tgaagcata  300
ccagggaag  agctgttgc  ggatgaccc  tatgagaaa  cttgccaga  gatgatctt  360
gagttgttt  ctaaggtgc  atccttggt  ggaagcttt  ttagaagcc  aaataaaga  420
gactatgct  gcctaaaag  agaatttcg  aaagaattt  ccaagctag  ggaggttct  480
actaataag  agacgacct  ctttggtgg  aattctatc  ctatgattg  ttacctcat  540
tggccctgg  ttgaacggc  ggaagcaat  aagttaaat  agtgtgtag  ccacactcc  600
aaactgaaa  tgtggatgg  agccatgaa  gaagatccc  cagtctcag  cctgcttac  660
agtgagaaa  actggcaag  tttcctaga  ctctactta  agaacagcc  tgaggcctg  720
gactatggg  tctgaaggg  gcaggagtc  gcaataaag  tatgtctga  attttcctt  780
agtaaaaaa  aaa  793



<210> 154
<211> 241
<212> PRT
<213> Homo sapiens
<308> P78417
<400> 154

Met Ser Gly Glu Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro 
  1               5                  10                  15
Gly Pro Val Pro Glu Gly Ser Ile Arg Ile Tyr Ser Met Arg Phe Cys 
             20                  25                  30
Pro Phe Ala Glu Arg Thr Arg Leu Val Leu Lys Ala Lys Gly Ile Arg 
         35                  40                  45
His Glu Val Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe 
     50                  55                  60
Lys Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Ser Gln Gly 
 65                  70                  75                  80
Gln Leu Ile Tyr Glu Ser Ala Ile Thr Cys Glu Tyr Leu Asp Glu Ala 
                 85                  90                  95
Tyr Pro Gly Lys Lys Leu Leu Pro Asp Asp Pro Tyr Glu Lys Ala Cys 
             100                105                110
Gln Lys Met Ile Leu Glu Leu Phe Ser Lys Val Pro Ser Leu Val Gly 
         115                120                125
Ser Phe Ile Arg Ser Gln Asn Lys Glu Asp Tyr Ala Gly Leu Lys Glu 
     130                135                140
Glu Phe Arg Lys Glu Phe Thr Lys Leu Glu Glu Val Leu Thr Asn Lys 
 145                150                155                160
Lys Thr Thr Phe Phe Gly Gly Asn Ser Ile Ser Met Ile Asp Tyr Leu 
                 165                170                175
Ile Trp Pro Trp Phe Glu Arg Leu Glu Ala Met Lys Leu Asn Glu Cys 
             180                185                190
Val Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Ala Met Lys Glu 
         195                200                205
Asp Pro Thr Val Ser Ala Leu Leu Thr Ser Glu Lys Asp Trp Gln Gly 
     210                215                220
Phe Leu Glu Leu Tyr Leu Gln Asn Ser Pro Glu Ala Cys Asp Tyr Gly 
 225                230                235                240
Leu 
                 245



<210> 155
<211> 3891
<212> DNA
<213> Rattus norvegicus
<308> AB009463
<400> 155

ccgatcgac  caccctcgt  gacatcgtg  ggcgcggcg  ggcgcgggc  gcccgggga  60
cgacgggca  gcgcaccgg  gcatgggcg  gccggaggt  tcggtgtgc  ggcagggct  120
ggtgcgccg  ccggggctc  gggacagcg  cgggctcag  tcttccctg  cgaccgctg  180
tgagccccc  cggggcccg  gacgccgcg  ccgatgtgg  ccagcgcgt  gcgggcctg  240
accgccgct  cacaaagac  ccgccgcag  cgccgcccg  accccggcc  cagccgccg  300
gccagccct  gccccaggc  gagtcccgg  cgcagggca  caggcgtcc  cgcgcggcc  360
gccacggca  ggagaagcg  gcggccgcg  ggccggagg  ggcgccggg  gccagggcg  420
cgctcgcag  cgtctgcct  gtgaacctc  ttctcactg  gagactcag  agtgcagtt  480
ctgccttag  tgcctgcag  gggaagttg  aacagcaca  tgaacggcg  ggggttatc  540
acagcccag  ctggcccct  aactaccct  caggcacca  ctgcagctg  tacattcaa  600
gtgaccgtg  tgacatgat  accatcagt  tccgaaact  tgatgtaga  gagtctcac  660
agtgttccc  ggactggct  ctgctgggc  cagcagctc  ccctcgcca  gaggccttc  720
gcctctgtg  ttcagccat  ccaccagcc  tcatctctg  ccgtgacca  gtctggatc  780
tcttccact  agacgcctc  agttccggc  aggcccagg  ttttcgcct  tcctatatc  840
gagggaagc  gggtcaggc  tcctgccag  cagatgagt  ccgctgtga  aacggtaaa  900
gcttgcctg  tccttggca  tgcaacatg  tggatgagt  tggagatgg  tcggatgag  960
gtaactgtt  ggcacctgc  tcagagcca  caggcagcc  gtgccccgg  ggcaccttc  1020
cgtgcagcg  agctcgctc  acacgctgc  tgccggtag  gcggcgctg  gacggcacc  1080
aggactgcg  tgatggctc  gatgaggct  gctgccccg  cctagcatg  ggccggcgg  1140
taggcagtt  ctacggttc  ttcgcctcc  cagacctgt  tggtgccgc  cgtgggcct  1200
cggaccttc  ctgcacatg  ctggtggac  cgcaggacc  gaggcgtgt  ctgctgcag  1260
tggagctac  actgggtta  gatgactat  tccaggtgt  tgaaggcct  ggcgagcgt  1320
gggaccgtc  gctgcaaac  ctttcctac  gcagcaacc  ccggcctgt  agcctggaa  1380
cagcgcagg  ccgcctcac  gtggcctac  atgctcgcg  ccgcagtgc  ggtcacggc  1440
tcaacgcca  ataccaggt  aagggctac  gcctcccat  ggagcagcc  tgtgggagc  1500
gcagcgagg  agatgacgg  agcacaggg  aacagggct  cttctcaga  ccacagcgc  1560
gtgatggct  gtggcattg  gcgagcggc  gggatgagc  gggctgtcc  gcatgccct  1620
cggaccagt  tccctgtga  ggtggtagc  gcctgtgct  tgcacctgc  gatcgttgc  1680
acaaccaga  aagctgccc  gatggcgcc  atgaaaaga  ctgcttttc  tgccagccg  1740
gcaccttcc  ctgtggtac  aacctgtgc  tctttgaga  atggcgctg  gacggtcag  1800
aggactgcc  agatggcag  gatgagcac  gctgcctgg  tgccgtgcc  cgcaaggtc  1860
tcaccgccg  cctcattgg  agcctagta  gcggactgc  gcttgttat  gccctaggc  1920
gtgccttca  actctactc  ctgcgcacg  aggagtaca  ggcctttga  acccaaatg  1980
cacgtttag  ggctgagtt  gtgcggcgc  aggcgcccc  atcctacgg  cagctcatc  2040
cacagggcc  cataccacc  gttgaggat  ttcctgtct  cagtgcatc  caggcttca  2100
tgctacaga  ccttcgcac  gccatgcga  gacagatgc  tcggcatgc  tcccgcagg  2160
ggccatctc  tcgcagact  ggccgcctc  ggaacaggc  cttccaccg  ccacgggca  2220
ctcgaggcc  gatcccact  ctgactgcc  cccgtacct  acagaccgt  ctgggtgat  2280
ggctcctcc  ggcagcacc  gggcctgta  cagaccccc  agtgcccaa  acagacaca  2340
gcagcccca  ggaggctgg  gatgggcct  ctagtggct  tggccatgc  ccagaagtg  2400
ggccttcag  gccgccccc  cccttgaac  ttcgagacc  agagtacag  ccagaggac  2460
aggagagaa  ggcctgtgt  gaccctctg  aagacagtc  agcccctgt  gacacacct  2520
cagagccct  cttggccca  gacccccac  cccagactc  cactgccag  ggcatccaa  2580
atccccact  agcagagcc  ctgggggtc  gcaggagcc  tccaccaac  tgctcccca  2640
tattggagg  tagtgatga  gaggccctg  tggtctgct  acccattgg  cacactggt  2700
actgccaca  ccccgcttt  gaaccaggg  atacacagt  atttctacc  tgcctctgc  2760
ttctttctt  cagagaccc  cctagcagc  ccggtgaag  gcctgggca  tcagtcagt  2820
ggctacctg  gcagtccta  tgctctgaa  ggcattact  tcaggggct  cgggggtgg  2880
cctgggaaa  agggaccga  cacctttga  atcagcatg  gcatagccc  ttggagtct  2940
acagcaaat  gctccctgc  acactaatc  cgggactca  ttccagaaa  gcaggagag  3000
cagaaccag  ctttccgga  tgttttctg  ggcttctca  tttatccac  ctgcagtgg  3060
accagctgc  catcctcag  cctgtgcca  gagctgtag  tgaggccta  aaaggccat  3120
agaggggta  ggtggacct  attcatggt  agtactata  tcatccttc  ccacagggt  3180
cctaggaaa  atgggctag  ggcttctgc  ccagtctca  gcctatggt  gcagcatag  3240
cctggctag  ctgggtcag  ccccaagta  catgggtaa  gctaaaagt  tgagatagg  3300
tgaccacaa  agaggccat  ctatgcctt  aaaggagac  gaagccaag  tactggctg  3360
caatggaaa  aaccattct  tcttgcctc  gagtctcag  ttccccacc  gaagagagg  3420
ctgtgctat  ataagtaat  gcattcact  tggtgattt  tgggaagga  agtagttca  3480
ctggggaat  tctgggttc  tctggatgg  caagttcaa  gtggcgtgg  gggttatgg  3540
tggagcctc  ttgtcttct  tgggcccca  ggagccagc  tcaggttca  ccagcaaaa  3600
ccactaggg  tgaaaacct  ctccatagc  ccttcccag  tagcaaccc  tataccgcg  3660
tgaggcatg  ctccatgaa  tccccttac  cacagaaca  ccagccctg  ttatttaca  3720
acttttctg  agaagctag  agggcattg  taaggcagg  agcccgacc  cagtggcca  3780
tcccttaca  taggcctct  agggtcggg  ctctttttt  gtgcagaaa  aaaaatttt  3840
gaaaacaaa  cagaacaca  accccttct  aataaacaa  atgtaaaca  a  3891



<210> 156
<211> 770
<212> PRT
<213> Rattus norvegicus
<308> BAA32331
<400> 156

Met Glu Lys Arg Ala Ala Ala Gly Pro Glu Gly Ala Pro Gly Ala Arg 
  1               5                  10                  15
Ala Pro Leu Ala Val Val Cys Leu Val Asn Leu Phe Leu Thr Gly Arg 
             20                  25                  30
Leu Ser Ser Ala Val Pro Ala Leu Ala Ala Cys Ser Gly Lys Leu Glu 
         35                  40                  45
Gln His Thr Glu Arg Arg Gly Val Ile Tyr Ser Pro Ala Trp Pro Leu 
     50                  55                  60
Asn Tyr Pro Pro Gly Thr Asn Cys Ser Trp Tyr Ile Gln Gly Asp Arg 
 65                  70                  75                  80
Gly Asp Met Ile Thr Ile Ser Phe Arg Asn Phe Asp Val Glu Glu Ser 
                 85                  90                  95
His Gln Cys Ser Leu Asp Trp Leu Leu Leu Gly Pro Ala Ala Pro Pro 
             100                105                110
Arg Gln Glu Ala Phe Arg Leu Cys Gly Ser Ala Ile Pro Pro Ala Phe 
         115                120                125
Ile Ser Ala Arg Asp His Val Trp Ile Phe Phe His Ser Asp Ala Ser 
     130                135                140
Ser Ser Gly Gln Ala Gln Gly Phe Arg Leu Ser Tyr Ile Arg Gly Lys 
 145                150                155                160
Leu Gly Gln Ala Ser Cys Gln Thr Asp Glu Phe Arg Cys Asp Asn Gly 
                 165                170                175
Lys Cys Leu Pro Gly Pro Trp Gln Cys Asn Met Val Asp Glu Cys Gly 
             180                185                190
Asp Gly Ser Asp Glu Gly Asn Cys Ser Ala Pro Ala Ser Glu Pro Pro 
         195                200                205
Gly Ser Leu Cys Pro Gly Gly Thr Phe Pro Cys Ser Gly Ala Arg Ser 
     210                215                220
Thr Arg Cys Leu Pro Val Glu Arg Arg Cys Asp Gly Thr Gln Asp Cys 
 225                230                235                240
Gly Asp Gly Ser Asp Glu Ala Gly Cys Pro Asp Leu Ala Cys Gly Arg 
                 245                250                255
Arg Leu Gly Ser Phe Tyr Gly Ser Phe Ala Ser Pro Asp Leu Phe Gly 
             260                265                270
Ala Ala Arg Gly Pro Ser Asp Leu His Cys Thr Trp Leu Val Asp Thr 
         275                280                285
Gln Asp Pro Arg Arg Val Leu Leu Gln Leu Glu Leu Arg Leu Gly Tyr 
     290                295                300
Asp Asp Tyr Val Gln Val Tyr Glu Gly Leu Gly Glu Arg Gly Asp Arg 
 305                310                315                320
Leu Leu Gln Thr Leu Ser Tyr Arg Ser Asn His Arg Pro Val Ser Leu 
                 325                330                335
Glu Ala Ala Gln Gly Arg Leu Thr Val Ala Tyr His Ala Arg Ala Arg 
             340                345                350
Ser Ala Gly His Gly Phe Asn Ala Thr Tyr Gln Val Lys Gly Tyr Cys 
         355                360                365
Leu Pro Trp Glu Gln Pro Cys Gly Ser Ser Ser Glu Gly Asp Asp Gly 
     370                375                380
Ser Thr Gly Glu Gln Gly Cys Phe Ser Glu Pro Gln Arg Cys Asp Gly 
 385                390                395                400
Trp Trp His Cys Ala Ser Gly Arg Asp Glu Gln Gly Cys Pro Ala Cys 
                 405                410                415
Pro Pro Asp Gln Tyr Pro Cys Glu Gly Gly Ser Gly Leu Cys Tyr Ala 
             420                425                430
Pro Ala Asp Arg Cys Asn Asn Gln Lys Ser Cys Pro Asp Gly Ala Asp 
         435                440                445
Glu Lys Asn Cys Phe Ser Cys Gln Pro Gly Thr Phe His Cys Gly Thr 
     450                455                460
Asn Leu Cys Ile Phe Glu Thr Trp Arg Cys Asp Gly Gln Glu Asp Cys 
 465                470                475                480
Gln Asp Gly Ser Asp Glu His Gly Cys Leu Ala Ala Val Pro Arg Lys 
                 485                490                495
Val Ile Thr Ala Ala Leu Ile Gly Ser Leu Val Cys Gly Leu Leu Leu 
             500                505                510
Val Ile Ala Leu Gly Cys Ala Phe Lys Leu Tyr Ser Leu Arg Thr Gln 
         515                520                525
Glu Tyr Arg Ala Phe Glu Thr Gln Met Thr Arg Leu Glu Ala Glu Phe 
     530                535                540
Val Arg Arg Glu Ala Pro Pro Ser Tyr Gly Gln Leu Ile Ala Gln Gly 
 545                550                555                560
Leu Ile Pro Pro Val Glu Asp Phe Pro Val Tyr Ser Ala Ser Gln Ala 
                 565                570                575
Ser Val Leu Gln Asn Leu Arg Thr Ala Met Arg Arg Gln Met Arg Arg 
             580                585                590
His Ala Ser Arg Arg Gly Pro Ser Arg Arg Arg Leu Gly Arg Leu Trp 
         595                600                605
Asn Arg Leu Phe His Arg Pro Arg Ala Pro Arg Gly Gln Ile Pro Leu 
     610                615                620
Leu Thr Ala Ala Arg Thr Ser Gln Thr Val Leu Gly Asp Gly Leu Leu 
 625                630                635                640
Gln Ala Ala Pro Gly Pro Val Pro Asp Pro Pro Val Pro Asn Thr Asp 
                 645                650                655
Thr Gly Ser Pro Arg Glu Ala Gly Asp Gly Pro Pro Ser Gly Ser Gly 
             660                665                670
His Ala Pro Glu Val Gly Pro Ser Val Pro Pro Pro Pro Leu Asn Leu 
         675                680                685
Arg Asp Pro Glu Tyr Arg Pro Glu Asp Lys Glu Arg Lys Ala Cys Val 
     690                695                700
Asp Pro Leu Glu Asp Ser Pro Ala Pro Val Asp Thr Pro Pro Glu Pro 
 705                710                715                720
Cys Leu Ala Gln Asp Pro His Pro Gln Thr Pro Thr Ala Ser Gly Ile 
                 725                730                735
Gln Asp Pro His Ser Ala Glu Pro Leu Gly Val Cys Arg Ser Pro Pro 
             740                745                750
Pro Thr Cys Ser Pro Ile Leu Glu Ala Ser Asp Asp Glu Ala Leu Leu 
         755                760                765
Val Cys 
     770



<210> 157
<211> 1918
<212> DNA
<213> Homo sapiens
<308> NM_019849
<400> 157

cggctgcga  ggccgtgag  tcacggacc  acggaccga  gggcggccg  ccggacaga  60
ggggcagcg  agggagcgg  gacgcggcg  gacagcgac  tggccggcc  cacgcagca  120
ccgagcggg  gcgggaacc  caggcctgc  ccctcgccc  ccccagtcc  agggaccgt  180
cccggcgcc  cggagcggg  ggcgctcaa  aaggagatc  ggctgctga  cgcctgcac  240
atcatcatc  ggaacatca  cggctcggg  atcttcatc  cgcccaagg  ggtcctgga  300
cactcaggc  ccgtgggtc  ggccctgtt  gtctgggtc  tgggtgggg  cgtgacggc  360
ctgggctcc  tctgctatg  agagctggg  gtcgccatc  ccaagtctg  cggggacta  420
gcctacgtc  cagagatct  cgggggcct  gctggcttt  tgctgctct  gagcgccgt  480
ctcatcatg  accccacca  ccttgctgt  atctccatg  ccttctcca  ctacgtgct  540
cagcccgtg  tccccaact  catcccccc  accacagcc  cccgggtgc  gtccatggc  600
tgcctgatg  tcctgacat  ggtgaacag  tccagtgtg  gctgggcca  gcgcatcca  660
gacatgttc  caggcggga  gctgctggc  ttgtccctc  tcatcggcg  gggccttct  720
cagatcttc  aaggacact  cgaggagct  aggcccagc  atgcctttg  tttctggat  780
acgccctcc  tgggacacc  ggccctggc  ttcctccag  gctccttcg  cttcagtgg  840
tggaacttc  tcaactatg  caccgagga  atggttgac  cccgaaaga  cctacctcg  900
gccatcttc  tctccatcc  actggtgac  ttcgtgtac  cgttcacca  cattgccta  960
ttcacggcc  tgtcccccc  ggagctgct  tcctccaat  cggtggctg  gaccttcgg  1020
gagaagctg  tgggctact  ttcttgggt  atgcctgtc  ccgtggctc  gtcaacctt  1080
ggagggatc  atggttacc  gttcaccta  tccaggctg  gcttctctg  agcccgcga  1140
gggcacctg  ccagcctgc  ggccatgat  cacgtcaga  actgcaccc  catccccgc  1200
ctcctcgtc  gttgcgggg  cacagccgt  atcatgctc  tgggcgaca  gtacacgct  1260
atcaactat  tgtccttca  caactacct  tgctacggc  tcaccatcc  gggcctgct  1320
ctgctgcgc  ggaggcggc  tgcactcca  aggcccatc  aggtgaacc  tctcatccc  1380
gtggcgtac  tggtcttct  ggccttcct  ctggtcttc  gcttcatct  agagcctat  1440
gtctgtggg  tcggcgtca  catcatcct  acgggggtg  ccattttct  tctgggagt  1500
ttctggaga  gcaaaccaa  gtgtgtgca  agactcaca  agtccatga  acactgggg  1560
caggagctg  gtttcgtgg  ctaccccca  gacgccccc  aagaggagg  gaatggccc  1620
tgcccaccc  ccctgctgc  tgccacaga  aagccctcg  agccacaat  agatttttg  1680
agagactga  gcagttgtt  ctgtttaca  gttgtttat  gaggaggtg  tttggcaaa  1740
aagttttgt  ttgtttttt  ctggaaaaa  aagaaaaaa  atacgactc  cagaagcct  1800
ttttaagga  gccctaaaa  gtggactgg  tttcctgtc  tagcactgc  ctgctagct  1860
ttcctgaaa  ggcctataa  taaacaggg  tggctgtta  aaaaaaaaa  aaaaaaaa  1918



<210> 158
<211> 770
<212> PRT
<213> Homo sapiens
<308> BAA32330
<400> 158

Met Glu Lys Arg Ala Ala Ala Gly Leu Glu Gly Ala Pro Gly Ala Arg 
  1               5                  10                  15
Ala Gln Leu Ala Val Val Cys Leu Val Asn Ile Phe Leu Thr Gly Arg 
             20                  25                  30
Leu Ser Ser Ala Val Pro Ala Leu Ala Ala Cys Ser Gly Lys Leu Glu 
         35                  40                  45
Gln His Thr Glu Arg Arg Gly Val Ile Tyr Ser Pro Ala Trp Pro Leu 
     50                  55                  60
Asn Tyr Pro Pro Gly Thr Asn Cys Ser Trp Tyr Ile Gln Gly Asp Arg 
 65                  70                  75                  80
Gly Asp Met Ile Thr Ile Ser Phe Arg Asn Phe Asp Val Glu Glu Ser 
                 85                  90                  95
His Gln Cys Ser Leu Asp Trp Leu Leu Leu Gly Pro Ala Ala Pro Pro 
             100                105                110
Arg Gln Glu Ala Phe Arg Leu Cys Gly Ser Ala Ile Pro Pro Ala Phe 
         115                120                125
Ile Ser Ala Arg Asp His Val Trp Ile Phe Phe His Ser Asp Ala Ser 
     130                135                140
Ser Ser Gly Gln Ala Gln Gly Phe Arg Leu Ser Tyr Ile Arg Gly Lys 
 145                150                155                160
Leu Gly Gln Ala Ser Cys Gln Ala Asp Glu Phe Arg Cys Asp Asn Gly 
                 165                170                175
Lys Cys Leu Pro Gly Pro Trp Gln Cys Asn Thr Val Asp Glu Cys Gly 
             180                185                190
Asp Gly Ser Asp Glu Gly Asn Cys Ser Ala Pro Ala Ser Glu Pro Pro 
         195                200                205
Gly Ser Leu Cys Pro Gly Gly Thr Phe Pro Cys Ser Gly Ala Arg Ser 
     210                215                220
Thr Arg Cys Leu Pro Val Glu Arg Arg Cys Asp Gly Leu Gln Asp Cys 
 225                230                235                240
Gly Asp Gly Ser Asp Glu Ala Gly Cys Pro Asp Leu Ala Cys Gly Arg 
                 245                250                255
Arg Leu Gly Ser Phe Tyr Gly Ser Phe Ala Ser Pro Asp Leu Phe Gly 
             260                265                270
Ala Ala Arg Gly Pro Ser Asp Leu His Cys Thr Trp Leu Val Asp Thr 
         275                280                285
Gln Asp Ser Arg Arg Val Leu Leu Gln Leu Glu Leu Arg Leu Gly Tyr 
     290                295                300
Asp Asp Tyr Val Gln Val Tyr Glu Gly Leu Gly Glu Arg Gly Asp Arg 
 305                310                315                320
Leu Leu Gln Thr Leu Ser Tyr Arg Ser Asn His Arg Pro Val Ser Leu 
                 325                330                335
Glu Ala Ala Gln Gly Arg Leu Thr Val Ala Tyr His Ala Arg Ala Arg 
             340                345                350
Ser Ala Gly His Gly Phe Asn Ala Thr Tyr Gln Val Lys Gly Tyr Cys 
         355                360                365
Leu Pro Trp Glu Gln Pro Cys Gly Ser Ser Ser Asp Ser Asp Gly Gly 
     370                375                380
Ser Leu Gly Asp Gln Gly Cys Phe Ser Glu Pro Gln Arg Cys Asp Gly 
 385                390                395                400
Trp Trp His Cys Ala Ser Gly Arg Asp Glu Gln Gly Cys Pro Ala Cys 
                 405                410                415
Pro Pro Asp Gln Tyr Pro Cys Glu Gly Gly Ser Gly Leu Cys Tyr Thr 
             420                425                430
Pro Ala Asp Arg Cys Asn Asn Gln Lys Ser Cys Pro Asp Gly Ala Asp 
         435                440                445
Glu Lys Asn Cys Phe Ser Cys Gln Pro Gly Thr Phe His Cys Gly Thr 
     450                455                460
Asn Leu Cys Ile Phe Glu Thr Trp Arg Cys Asp Gly Gln Glu Asp Cys 
 465                470                475                480
Gln Asp Gly Ser Asp Glu His Gly Cys Leu Ala Ala Val Pro Arg Lys 
                 485                490                495
Val Ile Thr Ala Ala Leu Ile Gly Ser Leu Val Cys Gly Leu Leu Leu 
             500                505                510
Val Ile Ala Leu Gly Cys Ala Phe Lys Leu Tyr Ser Leu Arg Thr Gln 
         515                520                525
Glu Tyr Arg Ala Phe Glu Thr Gln Met Thr Arg Leu Glu Ala Glu Phe 
     530                535                540
Val Arg Arg Glu Ala Pro Pro Ser Tyr Gly Gln Leu Ile Ala Gln Gly 
 545                550                555                560
Leu Ile Pro Pro Val Glu Asp Phe Pro Val Tyr Ser Ala Ser Gln Ala 
                 565                570                575
Ser Val Leu Gln Asn Leu Arg Thr Ala Met Arg Arg Gln Met Arg Arg 
             580                585                590
His Ala Ser Arg Arg Gly Pro Ser Arg Arg Arg Leu Gly Arg Leu Trp 
         595                600                605
Asn Arg Leu Phe His Arg Pro Arg Ala Pro Arg Gly Gln Ile Pro Leu 
     610                615                620
Leu Thr Ala Ala Arg Pro Ser Gln Thr Val Leu Gly Asp Gly Phe Leu 
 625                630                635                640
Gln Pro Ala Pro Gly Ala Ala Pro Asp Pro Pro Ala Pro Leu Met Asp 
                 645                650                655
Thr Gly Ser Thr Arg Ala Ala Gly Asp Arg Pro Pro Ser Ala Pro Gly 
             660                665                670
Arg Ala Pro Glu Val Gly Pro Ser Gly Pro Pro Leu Pro Ser Gly Leu 
         675                680                685
Arg Asp Pro Glu Cys Arg Pro Val Asp Lys Asp Arg Lys Val Cys Arg 
     690                695                700
Glu Pro Leu Ala Asp Gly Pro Ala Pro Ala Asp Ala Pro Arg Glu Pro 
 705                710                715                720
Cys Ser Ala Gln Asp Pro His Pro Gln Val Ser Thr Ala Ser Ser Thr 
                 725                730                735
Leu Gly Pro His Ser Pro Glu Pro Leu Gly Val Cys Arg Asn Pro Pro 
             740                745                750
Pro Pro Cys Ser Pro Met Leu Glu Ala Ser Asp Asp Glu Ala Leu Leu 
         755                760                765
Val Cys 
     770



<210> 159
<211> 3891
<212> DNA
<213> Rattus norvegicus
<308> AB009463
<400> 159

ccgatcgac  caccctcgt  gacatcgtg  ggcgcggcg  ggcgcgggc  gcccgggga  60
cgacgggca  gcgcaccgg  gcatgggcg  gccggaggt  tcggtgtgc  ggcagggct  120
ggtgcgccg  ccggggctc  gggacagcg  cgggctcag  tcttccctg  cgaccgctg  180
tgagccccc  cggggcccg  gacgccgcg  ccgatgtgg  ccagcgcgt  gcgggcctg  240
accgccgct  cacaaagac  ccgccgcag  cgccgcccg  accccggcc  cagccgccg  300
gccagccct  gccccaggc  gagtcccgg  cgcagggca  caggcgtcc  cgcgcggcc  360
gccacggca  ggagaagcg  gcggccgcg  ggccggagg  ggcgccggg  gccagggcg  420
cgctcgcag  cgtctgcct  gtgaacctc  ttctcactg  gagactcag  agtgcagtt  480
ctgccttag  tgcctgcag  gggaagttg  aacagcaca  tgaacggcg  ggggttatc  540
acagcccag  ctggcccct  aactaccct  caggcacca  ctgcagctg  tacattcaa  600
gtgaccgtg  tgacatgat  accatcagt  tccgaaact  tgatgtaga  gagtctcac  660
agtgttccc  ggactggct  ctgctgggc  cagcagctc  ccctcgcca  gaggccttc  720
gcctctgtg  ttcagccat  ccaccagcc  tcatctctg  ccgtgacca  gtctggatc  780
tcttccact  agacgcctc  agttccggc  aggcccagg  ttttcgcct  tcctatatc  840
gagggaagc  gggtcaggc  tcctgccag  cagatgagt  ccgctgtga  aacggtaaa  900
gcttgcctg  tccttggca  tgcaacatg  tggatgagt  tggagatgg  tcggatgag  960
gtaactgtt  ggcacctgc  tcagagcca  caggcagcc  gtgccccgg  ggcaccttc  1020
cgtgcagcg  agctcgctc  acacgctgc  tgccggtag  gcggcgctg  gacggcacc  1080
aggactgcg  tgatggctc  gatgaggct  gctgccccg  cctagcatg  ggccggcgg  1140
taggcagtt  ctacggttc  ttcgcctcc  cagacctgt  tggtgccgc  cgtgggcct  1200
cggaccttc  ctgcacatg  ctggtggac  cgcaggacc  gaggcgtgt  ctgctgcag  1260
tggagctac  actgggtta  gatgactat  tccaggtgt  tgaaggcct  ggcgagcgt  1320
gggaccgtc  gctgcaaac  ctttcctac  gcagcaacc  ccggcctgt  agcctggaa  1380
cagcgcagg  ccgcctcac  gtggcctac  atgctcgcg  ccgcagtgc  ggtcacggc  1440
tcaacgcca  ataccaggt  aagggctac  gcctcccat  ggagcagcc  tgtgggagc  1500
gcagcgagg  agatgacgg  agcacaggg  aacagggct  cttctcaga  ccacagcgc  1560
gtgatggct  gtggcattg  gcgagcggc  gggatgagc  gggctgtcc  gcatgccct  1620
cggaccagt  tccctgtga  ggtggtagc  gcctgtgct  tgcacctgc  gatcgttgc  1680
acaaccaga  aagctgccc  gatggcgcc  atgaaaaga  ctgcttttc  tgccagccg  1740
gcaccttcc  ctgtggtac  aacctgtgc  tctttgaga  atggcgctg  gacggtcag  1800
aggactgcc  agatggcag  gatgagcac  gctgcctgg  tgccgtgcc  cgcaaggtc  1860
tcaccgccg  cctcattgg  agcctagta  gcggactgc  gcttgttat  gccctaggc  1920
gtgccttca  actctactc  ctgcgcacg  aggagtaca  ggcctttga  acccaaatg  1980
cacgtttag  ggctgagtt  gtgcggcgc  aggcgcccc  atcctacgg  cagctcatc  2040
cacagggcc  cataccacc  gttgaggat  ttcctgtct  cagtgcatc  caggcttca  2100
tgctacaga  ccttcgcac  gccatgcga  gacagatgc  tcggcatgc  tcccgcagg  2160
ggccatctc  tcgcagact  ggccgcctc  ggaacaggc  cttccaccg  ccacgggca  2220
ctcgaggcc  gatcccact  ctgactgcc  cccgtacct  acagaccgt  ctgggtgat  2280
ggctcctcc  ggcagcacc  gggcctgta  cagaccccc  agtgcccaa  acagacaca  2340
gcagcccca  ggaggctgg  gatgggcct  ctagtggct  tggccatgc  ccagaagtg  2400
ggccttcag  gccgccccc  cccttgaac  ttcgagacc  agagtacag  ccagaggac  2460
aggagagaa  ggcctgtgt  gaccctctg  aagacagtc  agcccctgt  gacacacct  2520
cagagccct  cttggccca  gacccccac  cccagactc  cactgccag  ggcatccaa  2580
atccccact  agcagagcc  ctgggggtc  gcaggagcc  tccaccaac  tgctcccca  2640
tattggagg  tagtgatga  gaggccctg  tggtctgct  acccattgg  cacactggt  2700
actgccaca  ccccgcttt  gaaccaggg  atacacagt  atttctacc  tgcctctgc  2760
ttctttctt  cagagaccc  cctagcagc  ccggtgaag  gcctgggca  tcagtcagt  2820
ggctacctg  gcagtccta  tgctctgaa  ggcattact  tcaggggct  cgggggtgg  2880
cctgggaaa  agggaccga  cacctttga  atcagcatg  gcatagccc  ttggagtct  2940
acagcaaat  gctccctgc  acactaatc  cgggactca  ttccagaaa  gcaggagag  3000
cagaaccag  ctttccgga  tgttttctg  ggcttctca  tttatccac  ctgcagtgg  3060
accagctgc  catcctcag  cctgtgcca  gagctgtag  tgaggccta  aaaggccat  3120
agaggggta  ggtggacct  attcatggt  agtactata  tcatccttc  ccacagggt  3180
cctaggaaa  atgggctag  ggcttctgc  ccagtctca  gcctatggt  gcagcatag  3240
cctggctag  ctgggtcag  ccccaagta  catgggtaa  gctaaaagt  tgagatagg  3300
tgaccacaa  agaggccat  ctatgcctt  aaaggagac  gaagccaag  tactggctg  3360
caatggaaa  aaccattct  tcttgcctc  gagtctcag  ttccccacc  gaagagagg  3420
ctgtgctat  ataagtaat  gcattcact  tggtgattt  tgggaagga  agtagttca  3480
ctggggaat  tctgggttc  tctggatgg  caagttcaa  gtggcgtgg  gggttatgg  3540
tggagcctc  ttgtcttct  tgggcccca  ggagccagc  tcaggttca  ccagcaaaa  3600
ccactaggg  tgaaaacct  ctccatagc  ccttcccag  tagcaaccc  tataccgcg  3660
tgaggcatg  ctccatgaa  tccccttac  cacagaaca  ccagccctg  ttatttaca  3720
acttttctg  agaagctag  agggcattg  taaggcagg  agcccgacc  cagtggcca  3780
tcccttaca  taggcctct  agggtcggg  ctctttttt  gtgcagaaa  aaaaatttt  3840
gaaaacaaa  cagaacaca  accccttct  aataaacaa  atgtaaaca  a  3891



<210> 160
<211> 770
<212> PRT
<213> Rattus norvegicus
<308> BAA32331
<400> 160

Met Glu Lys Arg Ala Ala Ala Gly Pro Glu Gly Ala Pro Gly Ala Arg 
  1               5                  10                  15
Ala Pro Leu Ala Val Val Cys Leu Val Asn Leu Phe Leu Thr Gly Arg 
             20                  25                  30
Leu Ser Ser Ala Val Pro Ala Leu Ala Ala Cys Ser Gly Lys Leu Glu 
         35                  40                  45
Gln His Thr Glu Arg Arg Gly Val Ile Tyr Ser Pro Ala Trp Pro Leu 
     50                  55                  60
Asn Tyr Pro Pro Gly Thr Asn Cys Ser Trp Tyr Ile Gln Gly Asp Arg 
 65                  70                  75                  80
Gly Asp Met Ile Thr Ile Ser Phe Arg Asn Phe Asp Val Glu Glu Ser 
                 85                  90                  95
His Gln Cys Ser Leu Asp Trp Leu Leu Leu Gly Pro Ala Ala Pro Pro 
             100                105                110
Arg Gln Glu Ala Phe Arg Leu Cys Gly Ser Ala Ile Pro Pro Ala Phe 
         115                120                125
Ile Ser Ala Arg Asp His Val Trp Ile Phe Phe His Ser Asp Ala Ser 
     130                135                140
Ser Ser Gly Gln Ala Gln Gly Phe Arg Leu Ser Tyr Ile Arg Gly Lys 
 145                150                155                160
Leu Gly Gln Ala Ser Cys Gln Thr Asp Glu Phe Arg Cys Asp Asn Gly 
                 165                170                175
Lys Cys Leu Pro Gly Pro Trp Gln Cys Asn Met Val Asp Glu Cys Gly 
             180                185                190
Asp Gly Ser Asp Glu Gly Asn Cys Ser Ala Pro Ala Ser Glu Pro Pro 
         195                200                205
Gly Ser Leu Cys Pro Gly Gly Thr Phe Pro Cys Ser Gly Ala Arg Ser 
     210                215                220
Thr Arg Cys Leu Pro Val Glu Arg Arg Cys Asp Gly Thr Gln Asp Cys 
 225                230                235                240
Gly Asp Gly Ser Asp Glu Ala Gly Cys Pro Asp Leu Ala Cys Gly Arg 
                 245                250                255
Arg Leu Gly Ser Phe Tyr Gly Ser Phe Ala Ser Pro Asp Leu Phe Gly 
             260                265                270
Ala Ala Arg Gly Pro Ser Asp Leu His Cys Thr Trp Leu Val Asp Thr 
         275                280                285
Gln Asp Pro Arg Arg Val Leu Leu Gln Leu Glu Leu Arg Leu Gly Tyr 
     290                295                300
Asp Asp Tyr Val Gln Val Tyr Glu Gly Leu Gly Glu Arg Gly Asp Arg 
 305                310                315                320
Leu Leu Gln Thr Leu Ser Tyr Arg Ser Asn His Arg Pro Val Ser Leu 
                 325                330                335
Glu Ala Ala Gln Gly Arg Leu Thr Val Ala Tyr His Ala Arg Ala Arg 
             340                345                350
Ser Ala Gly His Gly Phe Asn Ala Thr Tyr Gln Val Lys Gly Tyr Cys 
         355                360                365
Leu Pro Trp Glu Gln Pro Cys Gly Ser Ser Ser Glu Gly Asp Asp Gly 
     370                375                380
Ser Thr Gly Glu Gln Gly Cys Phe Ser Glu Pro Gln Arg Cys Asp Gly 
 385                390                395                400
Trp Trp His Cys Ala Ser Gly Arg Asp Glu Gln Gly Cys Pro Ala Cys 
                 405                410                415
Pro Pro Asp Gln Tyr Pro Cys Glu Gly Gly Ser Gly Leu Cys Tyr Ala 
             420                425                430
Pro Ala Asp Arg Cys Asn Asn Gln Lys Ser Cys Pro Asp Gly Ala Asp 
         435                440                445
Glu Lys Asn Cys Phe Ser Cys Gln Pro Gly Thr Phe His Cys Gly Thr 
     450                455                460
Asn Leu Cys Ile Phe Glu Thr Trp Arg Cys Asp Gly Gln Glu Asp Cys 
 465                470                475                480
Gln Asp Gly Ser Asp Glu His Gly Cys Leu Ala Ala Val Pro Arg Lys 
                 485                490                495
Val Ile Thr Ala Ala Leu Ile Gly Ser Leu Val Cys Gly Leu Leu Leu 
             500                505                510
Val Ile Ala Leu Gly Cys Ala Phe Lys Leu Tyr Ser Leu Arg Thr Gln 
         515                520                525
Glu Tyr Arg Ala Phe Glu Thr Gln Met Thr Arg Leu Glu Ala Glu Phe 
     530                535                540
Val Arg Arg Glu Ala Pro Pro Ser Tyr Gly Gln Leu Ile Ala Gln Gly 
 545                550                555                560
Leu Ile Pro Pro Val Glu Asp Phe Pro Val Tyr Ser Ala Ser Gln Ala 
                 565                570                575
Ser Val Leu Gln Asn Leu Arg Thr Ala Met Arg Arg Gln Met Arg Arg 
             580                585                590
His Ala Ser Arg Arg Gly Pro Ser Arg Arg Arg Leu Gly Arg Leu Trp 
         595                600                605
Asn Arg Leu Phe His Arg Pro Arg Ala Pro Arg Gly Gln Ile Pro Leu 
     610                615                620
Leu Thr Ala Ala Arg Thr Ser Gln Thr Val Leu Gly Asp Gly Leu Leu 
 625                630                635                640
Gln Ala Ala Pro Gly Pro Val Pro Asp Pro Pro Val Pro Asn Thr Asp 
                 645                650                655
Thr Gly Ser Pro Arg Glu Ala Gly Asp Gly Pro Pro Ser Gly Ser Gly 
             660                665                670
His Ala Pro Glu Val Gly Pro Ser Val Pro Pro Pro Pro Leu Asn Leu 
         675                680                685
Arg Asp Pro Glu Tyr Arg Pro Glu Asp Lys Glu Arg Lys Ala Cys Val 
     690                695                700
Asp Pro Leu Glu Asp Ser Pro Ala Pro Val Asp Thr Pro Pro Glu Pro 
 705                710                715                720
Cys Leu Ala Gln Asp Pro His Pro Gln Thr Pro Thr Ala Ser Gly Ile 
                 725                730                735
Gln Asp Pro His Ser Ala Glu Pro Leu Gly Val Cys Arg Ser Pro Pro 
             740                745                750
Pro Thr Cys Ser Pro Ile Leu Glu Ala Ser Asp Asp Glu Ala Leu Leu 
         755                760                765
Val Cys 
     770



<210> 161
<211> 1918
<212> DNA
<213> Homo sapiens
<308> NM_019849
<400> 161

cggctgcga  ggccgtgag  tcacggacc  acggaccga  gggcggccg  ccggacaga  60
ggggcagcg  agggagcgg  gacgcggcg  gacagcgac  tggccggcc  cacgcagca  120
ccgagcggg  gcgggaacc  caggcctgc  ccctcgccc  ccccagtcc  agggaccgt  180
cccggcgcc  cggagcggg  ggcgctcaa  aaggagatc  ggctgctga  cgcctgcac  240
atcatcatc  ggaacatca  cggctcggg  atcttcatc  cgcccaagg  ggtcctgga  300
cactcaggc  ccgtgggtc  ggccctgtt  gtctgggtc  tgggtgggg  cgtgacggc  360
ctgggctcc  tctgctatg  agagctggg  gtcgccatc  ccaagtctg  cggggacta  420
gcctacgtc  cagagatct  cgggggcct  gctggcttt  tgctgctct  gagcgccgt  480
ctcatcatg  accccacca  ccttgctgt  atctccatg  ccttctcca  ctacgtgct  540
cagcccgtg  tccccaact  catcccccc  accacagcc  cccgggtgc  gtccatggc  600
tgcctgatg  tcctgacat  ggtgaacag  tccagtgtg  gctgggcca  gcgcatcca  660
gacatgttc  caggcggga  gctgctggc  ttgtccctc  tcatcggcg  gggccttct  720
cagatcttc  aaggacact  cgaggagct  aggcccagc  atgcctttg  tttctggat  780
acgccctcc  tgggacacc  ggccctggc  ttcctccag  gctccttcg  cttcagtgg  840
tggaacttc  tcaactatg  caccgagga  atggttgac  cccgaaaga  cctacctcg  900
gccatcttc  tctccatcc  actggtgac  ttcgtgtac  cgttcacca  cattgccta  960
ttcacggcc  tgtcccccc  ggagctgct  tcctccaat  cggtggctg  gaccttcgg  1020
gagaagctg  tgggctact  ttcttgggt  atgcctgtc  ccgtggctc  gtcaacctt  1080
ggagggatc  atggttacc  gttcaccta  tccaggctg  gcttctctg  agcccgcga  1140
gggcacctg  ccagcctgc  ggccatgat  cacgtcaga  actgcaccc  catccccgc  1200
ctcctcgtc  gttgcgggg  cacagccgt  atcatgctc  tgggcgaca  gtacacgct  1260
atcaactat  tgtccttca  caactacct  tgctacggc  tcaccatcc  gggcctgct  1320
ctgctgcgc  ggaggcggc  tgcactcca  aggcccatc  aggtgaacc  tctcatccc  1380
gtggcgtac  tggtcttct  ggccttcct  ctggtcttc  gcttcatct  agagcctat  1440
gtctgtggg  tcggcgtca  catcatcct  acgggggtg  ccattttct  tctgggagt  1500
ttctggaga  gcaaaccaa  gtgtgtgca  agactcaca  agtccatga  acactgggg  1560
caggagctg  gtttcgtgg  ctaccccca  gacgccccc  aagaggagg  gaatggccc  1620
tgcccaccc  ccctgctgc  tgccacaga  aagccctcg  agccacaat  agatttttg  1680
agagactga  gcagttgtt  ctgtttaca  gttgtttat  gaggaggtg  tttggcaaa  1740
aagttttgt  ttgtttttt  ctggaaaaa  aagaaaaaa  atacgactc  cagaagcct  1800
ttttaagga  gccctaaaa  gtggactgg  tttcctgtc  tagcactgc  ctgctagct  1860
ttcctgaaa  ggcctataa  taaacaggg  tggctgtta  aaaaaaaaa  aaaaaaaa  1918



<210> 162
<211> 770
<212> PRT
<213> Homo sapiens
<308> BAA32330
<400> 162

Met Glu Lys Arg Ala Ala Ala Gly Leu Glu Gly Ala Pro Gly Ala Arg 
  1               5                  10                  15
Ala Gln Leu Ala Val Val Cys Leu Val Asn Ile Phe Leu Thr Gly Arg 
             20                  25                  30
Leu Ser Ser Ala Val Pro Ala Leu Ala Ala Cys Ser Gly Lys Leu Glu 
         35                  40                  45
Gln His Thr Glu Arg Arg Gly Val Ile Tyr Ser Pro Ala Trp Pro Leu 
     50                  55                  60
Asn Tyr Pro Pro Gly Thr Asn Cys Ser Trp Tyr Ile Gln Gly Asp Arg 
 65                  70                  75                  80
Gly Asp Met Ile Thr Ile Ser Phe Arg Asn Phe Asp Val Glu Glu Ser 
                 85                  90                  95
His Gln Cys Ser Leu Asp Trp Leu Leu Leu Gly Pro Ala Ala Pro Pro 
             100                105                110
Arg Gln Glu Ala Phe Arg Leu Cys Gly Ser Ala Ile Pro Pro Ala Phe 
         115                120                125
Ile Ser Ala Arg Asp His Val Trp Ile Phe Phe His Ser Asp Ala Ser 
     130                135                140
Ser Ser Gly Gln Ala Gln Gly Phe Arg Leu Ser Tyr Ile Arg Gly Lys 
 145                150                155                160
Leu Gly Gln Ala Ser Cys Gln Ala Asp Glu Phe Arg Cys Asp Asn Gly 
                 165                170                175
Lys Cys Leu Pro Gly Pro Trp Gln Cys Asn Thr Val Asp Glu Cys Gly 
             180                185                190
Asp Gly Ser Asp Glu Gly Asn Cys Ser Ala Pro Ala Ser Glu Pro Pro 
         195                200                205
Gly Ser Leu Cys Pro Gly Gly Thr Phe Pro Cys Ser Gly Ala Arg Ser 
     210                215                220
Thr Arg Cys Leu Pro Val Glu Arg Arg Cys Asp Gly Leu Gln Asp Cys 
 225                230                235                240
Gly Asp Gly Ser Asp Glu Ala Gly Cys Pro Asp Leu Ala Cys Gly Arg 
                 245                250                255
Arg Leu Gly Ser Phe Tyr Gly Ser Phe Ala Ser Pro Asp Leu Phe Gly 
             260                265                270
Ala Ala Arg Gly Pro Ser Asp Leu His Cys Thr Trp Leu Val Asp Thr 
         275                280                285
Gln Asp Ser Arg Arg Val Leu Leu Gln Leu Glu Leu Arg Leu Gly Tyr 
     290                295                300
Asp Asp Tyr Val Gln Val Tyr Glu Gly Leu Gly Glu Arg Gly Asp Arg 
 305                310                315                320
Leu Leu Gln Thr Leu Ser Tyr Arg Ser Asn His Arg Pro Val Ser Leu 
                 325                330                335
Glu Ala Ala Gln Gly Arg Leu Thr Val Ala Tyr His Ala Arg Ala Arg 
             340                345                350
Ser Ala Gly His Gly Phe Asn Ala Thr Tyr Gln Val Lys Gly Tyr Cys 
         355                360                365
Leu Pro Trp Glu Gln Pro Cys Gly Ser Ser Ser Asp Ser Asp Gly Gly 
     370                375                380
Ser Leu Gly Asp Gln Gly Cys Phe Ser Glu Pro Gln Arg Cys Asp Gly 
 385                390                395                400
Trp Trp His Cys Ala Ser Gly Arg Asp Glu Gln Gly Cys Pro Ala Cys 
                 405                410                415
Pro Pro Asp Gln Tyr Pro Cys Glu Gly Gly Ser Gly Leu Cys Tyr Thr 
             420                425                430
Pro Ala Asp Arg Cys Asn Asn Gln Lys Ser Cys Pro Asp Gly Ala Asp 
         435                440                445
Glu Lys Asn Cys Phe Ser Cys Gln Pro Gly Thr Phe His Cys Gly Thr 
     450                455                460
Asn Leu Cys Ile Phe Glu Thr Trp Arg Cys Asp Gly Gln Glu Asp Cys 
 465                470                475                480
Gln Asp Gly Ser Asp Glu His Gly Cys Leu Ala Ala Val Pro Arg Lys 
                 485                490                495
Val Ile Thr Ala Ala Leu Ile Gly Ser Leu Val Cys Gly Leu Leu Leu 
             500                505                510
Val Ile Ala Leu Gly Cys Ala Phe Lys Leu Tyr Ser Leu Arg Thr Gln 
         515                520                525
Glu Tyr Arg Ala Phe Glu Thr Gln Met Thr Arg Leu Glu Ala Glu Phe 
     530                535                540
Val Arg Arg Glu Ala Pro Pro Ser Tyr Gly Gln Leu Ile Ala Gln Gly 
 545                550                555                560
Leu Ile Pro Pro Val Glu Asp Phe Pro Val Tyr Ser Ala Ser Gln Ala 
                 565                570                575
Ser Val Leu Gln Asn Leu Arg Thr Ala Met Arg Arg Gln Met Arg Arg 
             580                585                590
His Ala Ser Arg Arg Gly Pro Ser Arg Arg Arg Leu Gly Arg Leu Trp 
         595                600                605
Asn Arg Leu Phe His Arg Pro Arg Ala Pro Arg Gly Gln Ile Pro Leu 
     610                615                620
Leu Thr Ala Ala Arg Pro Ser Gln Thr Val Leu Gly Asp Gly Phe Leu 
 625                630                635                640
Gln Pro Ala Pro Gly Ala Ala Pro Asp Pro Pro Ala Pro Leu Met Asp 
                 645                650                655
Thr Gly Ser Thr Arg Ala Ala Gly Asp Arg Pro Pro Ser Ala Pro Gly 
             660                665                670
Arg Ala Pro Glu Val Gly Pro Ser Gly Pro Pro Leu Pro Ser Gly Leu 
         675                680                685
Arg Asp Pro Glu Cys Arg Pro Val Asp Lys Asp Arg Lys Val Cys Arg 
     690                695                700
Glu Pro Leu Ala Asp Gly Pro Ala Pro Ala Asp Ala Pro Arg Glu Pro 
 705                710                715                720
Cys Ser Ala Gln Asp Pro His Pro Gln Val Ser Thr Ala Ser Ser Thr 
                 725                730                735
Leu Gly Pro His Ser Pro Glu Pro Leu Gly Val Cys Arg Asn Pro Pro 
             740                745                750
Pro Pro Cys Ser Pro Met Leu Glu Ala Ser Asp Asp Glu Ala Leu Leu 
         755                760                765
Val Cys 
     770



<210> 163
<211> 5990
<212> DNA
<213> Rattus norvegicus
<308> AB009636
<400> 163

gaggaagca  agaccgggc  aaacacatg  aggaaaatt  ggaacttct  ttataatat  60
aacaagaca  ttggggcca  ataaatcct  tccgttaca  aaaaccaaa  atggcatac  120
attggcaaa  agagccaaa  cgtgctgaa  cacaggaag  tggacatga  caccagcag  180
gtcaccatg  agaccagca  ctttcttcc  ggcaagtca  gttgggttt  gatcagctt  240
tggaagagc  cagtaacaa  actccactg  ctgaggatg  aaaagaagg  acgtgtttt  300
taccagata  accaaactt  gattcaaaa  ggcaatcca  atatggacc  cacccaagg  360
acttcaatg  attcacttc  cagagtccc  acttctccc  gcttccttt  ggaaaagca  420
cagccattg  ttttaatcc  gctgtatta  ctgcacatc  gttcattca  gagggagcc  480
cctggagaa  tcccacaag  aaatatcat  gtggtgagg  tcccaggtt  agtgctcta  540
ctccgtcat  cactggctt  gataaatgt  atcaacaag  acaatcagg  accgaacat  600
gtaactatt  tgtggaacc  gaaaacaat  ttccccatc  ttattcacc  tactcaatg  660
actccatac  cgatagtga  gaaaaagga  gtggagatg  ggatcttgt  gaaccttct  720
tggtgttct  taaagactc  tttctaccc  gggcatcgg  gaacatgtc  gtggaaagc  780
cagagccca  tggttgccc  cttgaaata  ttgaagcac  ccaagggag  aacaagagc  840
tcgcctcct  ttgcaacaa  gtaacaaaa  taagaggac  atatcatgc  agtgacact  900
attccaatt  cggaaagat  tgggccatc  ccacagcct  tccatctcg  ctcttcgct  960
acacccagt  cagagttaa  atttccact  ataactcgg  acaacttct  cttcttaag  1020
cacccgcta  ttatcttgt  aaagaccta  ttgccgaaa  tctactttt  tgtgcaaat  1080
agcagcttt  ccccaaaga  tatcttcta  gtatatgcg  ttctgagga  tttttacag  1140
cggatcact  tctagggag  cacaaaata  ttcagaaaa  taaatctgt  attcaactc  1200
atctccaga  aagcaggga  actccagga  aattatccc  gaagaggga  gatgaccgc  1260
gtcgggtcc  tctgaacca  cttctagaa  ttacacata  ttggaaaat  tccagacaa  1320
gcctctcca  agtaatgaa  agctacaac  tccatgtcg  gcacctgtt  aaaacccag  1380
aagatgtgg  ggagaaacc  ctgtcatcc  tgttttcct  tggccgaca  cctcctcag  1440
cacatggga  tgacattat  gaagatgtt  gaaacatat  cagtgttct  gggtgtatt  1500
aaaccaaac  agtttcaga  gcagtaaaa  aactaactc  aattctgca  agaccatca  1560
agaattttc  tcagaattc  gagacttca  aaaaaggct  catagagaa  gtgacatcg  1620
aactgtcga  gtccctcca  cagctggtt  acgtgtact  cagtagctt  tgtacagat  1680
tccggcctg  gcgcgcacc  ggaggcgtc  cccgcgacc  cgctgggct  cactcccac  1740
tgagcttca  ggtgtgttc  ctgcacaat  ttccagaaa  ttgggcaca  agctacaaa  1800
cattttcat  ttcctgctg  ctcacatat  ctgggaaga  gctgtgcca  gtgaaaagc  1860
gcagatccc  gccagtcac  aagtcattc  ctttttcgg  gaactggaa  gaaataatc  1920
attttcctc  tgagataaa  tcacttcca  gagaatcca  gctcgttat  aagctgttt  1980
ggattgaca  tgccaccca  agcgcaaat  tgctggcct  gacctgcct  ccactattt  2040
caaaagaaa  gtctccgct  gggtctagg  ttctcagca  gacactaca  agtgagcct  2100
ctatagaaa  gatggctcc  ggagtatgg  atgggagcc  gcctacccc  ctgaccctg  2160
agatagatt  tccagctgc  acgtgggag  acgtgaaac  tgagactga  gagaacaga  2220
ctgaccacc  agagcctcc  agagagtgt  taaaacaca  cgccagact  tcccaaaag  2280
agcctccct  gctactttc  gtggaaaag  ggagatatt  gtggtttta  cgtttctac  2340
gcaacaatg  gaactcctc  ctccctctg  tcttgggca  cgcccctgg  tgggatgaa  2400
ggacagttt  ggaaatgca  gccgtcttg  gaaggtgga  attttccca  ccgttggaa  2460
ctcttggcc  tttgacttc  aggtttcca  accaagaca  tcgtgaagt  gccgttcaa  2520
agttagaca  cttcttgac  gatgagctg  tggactgcc  cccacagct  gttcaggct  2580
tcaagtttg  gtggagtct  gaaagtccc  tggtggaac  cctgcttca  cgatccttg  2640
aaagcatcc  agtggctca  cgcctgttc  ggctgctgc  ggatgcaca  ggtgaagac  2700
actttaaaa  ctggtacca  gagcttttg  ccgctctcc  gttctgtgc  ggagaagcc  2760
tgatcgaag  gctttccaa  gagcagaaa  ttgtcaaac  cctgggtga  attggagaa  2820
aagtgaagt  ggctggcga  gctcagaga  aggatgtgc  aaagaagga  attggcagt  2880
tagaagaat  ctttaaaga  ataaagact  gccatcttc  tctgaaccc  gccctgtgc  2940
taaaaggaa  tgatcggga  gcatgttca  atttcacat  taatgcctt  ccattgaag  3000
tcactttca  caatgctaa  ccaatgggc  aaaatatca  tgttatttt  aaggccggc  3060
acgatcttc  gcaggatat  cttgttctg  agattattc  agtgatgga  aacgtttgg  3120
ttcaggagg  cctcgatat  caaatgatc  tttatggat  tctagccac  ggaaaggct  3180
aaggattca  agagatggt  cctgatgct  taacgcttg  caagatcca  ctgcactct  3240
ggctgatag  acccctgaa  gaaaacacc  tcaagaagt  gttcagtca  cacaaccac  3300
taaaggaag  ttatgaaaa  gccttgagg  acttttttt  ctcttgtgc  ggctggtgt  3360
tggtgacat  catcttggg  gtctgtgac  gacataatg  caatatcat  ctgacaaag  3420
caggccaca  gtttcatat  gactttgga  aattcttgg  tcacgcaca  acatttggc  3480
gtataaaaa  ggaccgagc  cctttcatt  ttacttcag  gatggagta  tttattacg  3540
agggtggga  aaacacaca  cattttcaa  acttcgtgg  actctgctg  agagcctac  3600
acattgtga  gaagcacag  caactgctc  tgagccttc  agaaatgat  ctgcatgcc  3660
ggcttcctg  gctgagggg  attgaagac  tgaaatacg  acacgacaa  ctccggcca  3720
aagacacag  cctggaagc  acaagtcat  ttaccacga  gataaagca  agtctggag  3780
gcttcccag  taaactgaa  aacctgatc  acacgcttg  acagatgcc  gccttcagc  3840
ttgccagac  tgcccctca  actcctccc  aggagtgct  cgtcctgaa  aaaaccagg  3900
caattcaga  agtcacaat  ttagggttc  gcaagacac  cagcaacct  tacctgatc  3960
aggtgacac  cagcgacaa  aggaaaaac  tggccaaaa  gtccttcga  cagttttac  4020
gacttcaca  ccagattca  aagcagttc  ccttgttga  tctcccaga  tttcctcac  4080
ggtggcatc  acctttcac  gactcgcac  atgagagaa  ccgagatct  agtcactac  4140
tggaacagg  gctgcacgg  tcttacgaa  tcgcaaaca  tgattgtgt  ctcagtttt  4200
ttctctctg  acatataca  cagaccctt  aagactctc  atttgtgga  ccaggtgac  4260
attctccag  caagagccc  caggtgcag  tgctgatga  ctatgagga  acaaagctc  4320
ccatcctag  gaaacactt  aaaaacatc  atctcccag  tggctcagc  cccagcgca  4380
atgttgaaa  ttatcttct  ccacatccc  gtgaagttc  caggaagaa  acaaagtgc  4440
ttccaaaat  cactgaccc  acttacaat  aaattgtgg  atatgatga  gtctcagga  4500
ttcagggac  tgttttaat  ctcattgtg  agagcaaaa  tgtatttgt  ggagcggtt  4560
acattcagc  ctgcagtgt  cccctcaat  aagaaaagt  gtacccatt  gggaacagt  4620
tcatctgac  aatgccatg  atgtatgca  tattgatta  gtacttgtg  gttttcagc  4680
tccatttcc  ctatagcat  cacaaggca  ctttcttgc  gaagatggc  tggagcagt  4740
gttctcact  agcgtccct  acactgcga  cctttaata  aattcctgg  gattgtagt  4800
acccaaacc  caaaattat  ttagttgct  tttcacaac  gtaattttg  cacggttat  4860
aattgcaat  tatatatct  atctacagg  tacctacta  tcgacccct  tgataaaag  4920
gtcattgga  aatcccaaa  ggtcatgac  catgggttg  gaaccacag  cttagagtg  4980
tcacagaag  agcagatca  aatcagtct  ttgtagctc  ttcttctct  ccttctcct  5040
attttctta  catattttc  ccttggaat  ttcatcatg  aaaatccca  atgcaaagt  5100
atgaaagaa  gattcattt  atatgcatt  ttgaatcaa  ctaagttca  gtcttgcct  5160
aattgcttg  tgaggtcaa  attatactt  tagggtgtt  tctaaagct  ggagaagct  5220
atgtaaggg  taagaatat  tgcaatata  ttcaaaagt  aaatatgtg  acaagccac  5280
tatctagtc  tgattgaat  tattgagag  attggtgat  tccaaccat  tgctataat  5340
tttctatca  aaaaaaatc  ctaagattt  tctattgca  agatttttt  tctttaaga  5400
tttcatgca  gtatatagt  ctttcgtta  tgtagcttc  ctctttttt  gttgtcccc  5460
cacccatca  caactgttc  tctctaaaa  tcctgtatt  ctgtgggga  ttttatttt  5520
aagatgggc  tcaaactat  tatcccagc  gacctagag  ttgctatgt  gaccaggtg  5580
gccccaaat  acagtggtc  tcctgcctc  gtttcccga  cgctaaggt  ccaggtcat  5640
ggatcttgt  tgtaatttt  aagttcagt  cttagaatt  gatattgat  aatccagtg  5700
cattgtgtc  tccagcctc  gtcatgttc  caccttaaa  cttattaat  tccaaaccc  5760
aaatatcca  cttttaagt  caccattta  aacgcctct  tgcgtgtta  atactctca  5820
tgcacttga  ccaacacct  gtgttcgca  ggaccagat  gatgatctc  cagtttgtc  5880
cctgtgtaa  aggcaaacc  agaggacgc  tccaagata  tcaaactgg  ggtttcaaa  5940
ataaaacat  tgccataaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  5990



<210> 164
<211> 1505
<212> PRT
<213> Rattus norvegicus
<308> O70173
<400> 164

Met Ala Tyr Asn Trp Gln Thr Glu Pro Asn Arg Ala Glu Pro Gln Glu 
  1               5                  10                  15
Gly Gly His Asp His Gln Gln Cys His His Ala Asp Gln His Leu Ser 
             20                  25                  30
Ser Arg Gln Val Arg Leu Gly Phe Asp Gln Leu Val Glu Glu Leu Ser 
         35                  40                  45
Asn Lys Thr Pro Leu Pro Glu Asp Glu Lys Glu Gly Thr Cys Phe Val 
     50                  55                  60
Pro Asp Thr Pro Asn Leu Asp Ser Lys Trp Gln Ser Ile Tyr Gly Pro 
 65                  70                  75                  80
His Pro Arg His Phe Asn Glu Phe Thr Ser Gln Ser Pro His Phe Ser 
                 85                  90                  95
Gln Leu Pro Phe Gly Lys Ala Ser Ala Ile Gly Phe Asn Pro Ala Val 
             100                105                110
Leu Pro Ala His Gln Phe Ile His Glu Gly Ala Ser Trp Arg Asn Pro 
         115                120                125
Thr Arg Lys Tyr His Gly Gly Glu Asp Pro Arg Phe Ser Ala Leu Thr 
     130                135                140
Pro Ser Ser Thr Gly Leu Asp Lys Cys His Gln Gln Gly Gln Ser Gly 
 145                150                155                160
Thr Glu His Cys Asn Tyr Tyr Val Glu Pro Glu Asn Asn Val Pro His 
                 165                170                175
His Tyr Ser Pro Tyr Ser Met Asp Ser Ile Pro Asp Ser Glu Glu Lys 
             180                185                190
Gly Ser Gly Asp Ala Asp Leu Val Glu Pro Ser Leu Val Phe Ser Lys 
         195                200                205
Asp Ser Phe Leu Pro Arg Ala Ser Glu Asn Met Ser Val Glu Ser Thr 
     210                215                220
Glu Pro Ile Gly Cys Pro Leu Glu Ile Val Glu Ala Pro Gln Gly Ser 
 225                230                235                240
Asn Lys Ser Leu Ala Ser Phe Cys Asn Asn Val Thr Lys Ile Arg Gly 
                 245                250                255
Leu Tyr His Ala Ser Asp Thr Asn Ser Asn Ser Gly Lys Ile Trp Ala 
             260                265                270
Ile Thr Thr Ala Tyr Pro Ser Arg Leu Phe Ala Asp Thr Gln Phe Arg 
         275                280                285
Val Lys Ile Ser Thr Asp Asn Ser Ala Gln Leu Leu Leu Leu Lys Pro 
     290                295                300
Pro Ala Asn Tyr Leu Val Lys Asp Leu Ile Ala Glu Ile Leu Leu Leu 
 305                310                315                320
Cys Ala Asn Glu Gln Leu Ser Pro Lys Glu Tyr Leu Leu Ser Ile Cys 
                 325                330                335
Gly Ser Glu Glu Phe Leu Gln Thr Asp His Cys Leu Gly Ser His Lys 
             340                345                350
Ile Phe Gln Lys Ser Lys Ser Val Ile Gln Leu His Leu Gln Arg Ser 
         355                360                365
Arg Asp Thr Pro Gly Lys Leu Ser Arg Lys Arg Asp Asp Asp Arg Ser 
     370                375                380
Arg Val His Leu Asn Gln Leu Leu Glu Phe Thr His Ile Trp Lys Ile 
 385                390                395                400
Ser Arg Gln Cys Leu Ser Thr Val Met Lys Ser Tyr Asn Leu His Val 
                 405                410                415
Glu His Leu Leu Lys Thr Gln Glu Asp Val Glu Glu Lys Pro Leu Ser 
             420                425                430
Ser Met Phe Ser Cys Gly Arg His Pro Pro Gln Pro His Gly Asn Asp 
         435                440                445
Ile Ile Glu Asp Val Arg Asn Ile Cys Ser Val Leu Gly Cys Ile Glu 
     450                455                460
Thr Lys Gln Val Ser Asp Ala Val Lys Glu Leu Thr Leu Ile Leu Gln 
 465                470                475                480
Arg Pro Ser Gln Asn Phe His Gln Asn Ser Glu Thr Ser Lys Lys Gly 
                 485                490                495
Phe Ile Glu Asn Val Thr Ser Glu Leu Ser Arg Ser Leu His Gln Leu 
             500                505                510
Val Asp Val Tyr Cys Ser Ser Phe Cys Thr Asp Phe Arg Pro Ala Arg 
         515                520                525
Ala Pro Gly Gly Val Ser Arg Asp His Ala Gly Leu His Ser His Leu 
     530                535                540
Ser Phe Thr Val Cys Ser Leu His Asn Val Pro Glu Thr Trp Ala His 
 545                550                555                560
Ser Tyr Lys Ala Phe Ser Phe Ser Cys Trp Leu Thr Tyr Ala Gly Lys 
                 565                570                575
Lys Leu Cys Gln Val Lys Ser Cys Arg Ser Leu Pro Val Thr Lys Ser 
             580                585                590
Phe Ser Phe Ser Val Asn Trp Asn Glu Ile Ile Asn Phe Pro Leu Glu 
         595                600                605
Ile Lys Ser Leu Pro Arg Glu Ser Met Leu Val Ile Lys Leu Phe Gly 
     610                615                620
Ile Asp Ser Ala Thr His Ser Ala Asn Leu Leu Ala Trp Thr Cys Leu 
 625                630                635                640
Pro Leu Phe Pro Lys Glu Lys Ser Pro Leu Gly Ser Arg Leu Leu Ser 
                 645                650                655
Met Thr Leu Gln Ser Glu Pro Pro Ile Glu Met Met Ala Pro Gly Val 
             660                665                670
Trp Asp Gly Ser Gln Pro Thr Pro Leu Thr Leu Gln Ile Asp Phe Pro 
         675                680                685
Ala Ala Thr Trp Glu Tyr Val Lys Pro Glu Thr Glu Glu Asn Arg Thr 
     690                695                700
Asp His Gln Glu Pro Pro Arg Glu Cys Leu Lys His Ile Ala Arg Leu 
 705                710                715                720
Ser Gln Lys Gln Pro Pro Leu Leu Leu Ser Val Glu Lys Arg Arg Tyr 
                 725                730                735
Leu Trp Phe Tyr Arg Phe Tyr Cys Asn Asn Glu Asn Ser Ser Leu Pro 
             740                745                750
Leu Val Leu Gly Ser Ala Pro Gly Trp Asp Glu Gly Thr Val Ser Glu 
         755                760                765
Met His Ala Val Leu Arg Arg Trp Thr Phe Ser His Pro Leu Glu Ala 
     770                775                780
Leu Gly Leu Leu Thr Ser Arg Phe Pro Asp Gln Asp Ile Arg Glu Val 
 785                790                795                800
Ala Val Gln Gln Leu Asp Asn Phe Leu Thr Asp Glu Leu Leu Asp Cys 
                 805                810                815
Leu Pro Gln Leu Val Gln Ala Val Lys Phe Glu Trp Ser Leu Glu Ser 
             820                825                830
Pro Leu Val Glu Leu Leu Leu His Arg Ser Leu Gln Ser Ile Arg Val 
         835                840                845
Ala His Arg Leu Phe Trp Leu Leu Arg Asp Ala Gln Gly Glu Asp Tyr 
     850                855                860
Phe Lys Ser Trp Tyr Gln Glu Leu Leu Ala Ala Leu Gln Phe Cys Ala 
 865                870                875                880
Gly Glu Ala Leu Ile Glu Glu Leu Ser Lys Glu Gln Lys Leu Val Lys 
                 885                890                895
Leu Leu Gly Asp Ile Gly Glu Lys Val Lys Ser Ala Gly Asp Ala Gln 
             900                905                910
Arg Lys Asp Val Leu Lys Lys Glu Ile Gly Ser Leu Glu Glu Phe Phe 
         915                920                925
Lys Asp Ile Lys Thr Cys His Leu Pro Leu Asn Pro Ala Leu Cys Val 
     930                935                940
Lys Gly Ile Asp Arg Asp Ala Cys Ser Tyr Phe Thr Ser Asn Ala Leu 
 945                950                955                960
Pro Leu Lys Ile Thr Phe Ile Asn Ala Asn Pro Met Gly Lys Asn Ile 
                 965                970                975
Ser Val Ile Phe Lys Ala Gly Asp Asp Leu Arg Gln Asp Met Leu Val 
             980                985                990
Leu Gln Ile Ile Gln Val Met Asp Asn Val Trp Leu Gln Glu Gly Leu 
         995                1000                1005
Asp Met Gln Met Ile Ile Tyr Gly Cys Leu Ala Thr Gly Lys Ala Gln 
     1010                1015                1020
Gly Phe Ile Glu Met Val Pro Asp Ala Val Thr Leu Ala Lys Ile His 
 1025                1030                1035                1040
Leu His Ser Gly Leu Ile Gly Pro Leu Lys Glu Asn Thr Ile Lys Lys 
                 1045                1050                1055
Trp Phe Ser Gln His Asn His Leu Lys Glu Asp Tyr Glu Lys Ala Leu 
             1060                1065                1070
Arg Asn Phe Phe Tyr Ser Cys Ala Gly Trp Cys Val Val Thr Phe Ile 
         1075                1080                1085
Leu Gly Val Cys Asp Arg His Asn Asp Asn Ile Met Leu Thr Lys Ser 
     1090                1095                1100
Gly His Met Phe His Ile Asp Phe Gly Lys Phe Leu Gly His Ala Gln 
 1105                1110                1115                1120
Thr Phe Gly Gly Ile Lys Arg Asp Arg Ala Pro Phe Ile Phe Thr Ser 
                 1125                1130                1135
Glu Met Glu Tyr Phe Ile Thr Glu Gly Gly Lys Asn Thr Gln His Phe 
             1140                1145                1150
Gln Asp Phe Val Glu Leu Cys Cys Arg Ala Tyr Asn Ile Val Arg Lys 
         1155                1160                1165
His Ser Gln Leu Leu Leu Ser Leu Leu Glu Met Met Leu His Ala Gly 
     1170                1175                1180
Leu Pro Glu Leu Arg Gly Ile Glu Asp Leu Lys Tyr Val His Asp Asn 
 1185                1190                1195                1200
Leu Arg Pro Gln Asp Thr Asp Leu Glu Ala Thr Ser His Phe Thr Thr 
                 1205                1210                1215
Lys Ile Lys Gln Ser Leu Glu Cys Phe Pro Val Lys Leu Asn Asn Leu 
             1220                1225                1230
Ile His Thr Leu Ala Gln Met Pro Ala Phe Ser Leu Ala Arg Pro Ala 
         1235                1240                1245
Pro Gln Thr Pro Pro Gln Glu Cys Cys Val Leu Asn Lys Thr Arg Thr 
     1250                1255                1260
Ile Gln Arg Val Thr Ile Leu Gly Phe Ser Lys Thr His Ser Asn Leu 
 1265                1270                1275                1280
Tyr Leu Ile Glu Val Thr Arg Ser Asp Asn Arg Lys Asn Leu Ala Lys 
                 1285                1290                1295
Lys Ser Phe Glu Gln Phe Tyr Arg Leu His Ser Gln Ile Gln Lys Gln 
             1300                1305                1310
Phe Pro Leu Leu Thr Leu Pro Glu Phe Pro His Trp Trp His Leu Pro 
         1315                1320                1325
Phe Thr Asp Ser His His Glu Arg Ile Arg Asp Leu Ser His Tyr Val 
     1330                1335                1340
Glu Gln Val Leu His Gly Ser Tyr Glu Val Ala Asn Ser Asp Cys Val 
 1345                1350                1355                1360
Leu Ser Phe Phe Leu Ser Glu His Ile Gln Gln Thr Leu Glu Asp Ser 
                 1365                1370                1375
Pro Phe Val Asp Pro Gly Asp His Ser Pro Asp Lys Ser Pro Gln Val 
             1380                1385                1390
Gln Leu Leu Met Thr Tyr Glu Asp Thr Lys Leu Thr Ile Leu Val Lys 
         1395                1400                1405
His Leu Lys Asn Ile His Leu Pro Asp Gly Ser Ala Pro Ser Ala His 
     1410                1415                1420
Val Glu Ile Tyr Leu Leu Pro His Pro Ser Glu Val Arg Arg Lys Lys 
 1425                1430                1435                1440
Thr Lys Cys Val Pro Lys Cys Thr Asp Pro Thr Tyr Asn Glu Ile Val 
                 1445                1450                1455
Val Tyr Asp Asp Val Ser Gly Leu Gln Gly His Val Leu Met Leu Ile 
             1460                1465                1470
Val Lys Ser Lys Thr Val Phe Val Gly Ala Val Asn Ile Gln Leu Cys 
         1475                1480                1485
Ser Val Pro Leu Asn Glu Glu Lys Trp Tyr Pro Leu Gly Asn Ser Ile 
     1490                1495                1500
Ile 
 1505



<210> 165
<211> 4880
<212> DNA
<213> Homo sapiens
<308> AJ000008
<400> 165

ggctcgagc  gccgcccgg  caggttgag  tcgtgtttc  tttcaggaa  atatatgcg  60
caggaaaat  tctatcttc  tttgtatta  caaggagat  tttggagca  agtcaaccc  120
ctcagttac  taaaataaa  aatggcata  tcttggcaa  cggatccaa  tcctaatga  180
tcacacgaa  agcagtatg  acaccaaga  tttctcttt  taaatcaac  ccattcttc  240
agccaagtc  gtctgggtt  tgatcagat  gtagatgag  tcagtggca  aattccaca  300
tacgagagt  aaattgatg  aaacacctt  tttgtgccc  ctgcaccaa  atgggactc  360
acagggcat  cattaaatg  agcacacca  atatccttg  atgaattca  ttctaaaag  420
cgtgaactc  cctggcatc  agttagcaa  gcaccagca  ttggtttta  tccttctgt  480
ttaccaaaa  ctcaaaata  gaataaaga  tgctcctgg  gaagcccca  aggaaaaca  540
catggtgct  atgattcca  attcagtat  ttagctcca  cattcacaa  tttggataa  600
attaatcta  agaaagaat  agaaaatga  aatcataac  accatatag  atttgaaag  660
agcattcct  caacaaatt  atccttctc  agtgacttc  tgccgaaag  agagaataa  720
aggagtgga  atgtgaaca  tgtggaacc  tctttgatg  ttttgaaag  ctctcttca  780
cccggaatg  gggaaagta  atggcagaa  aatatagag  caataggtt  ttccattca  840
ctagtggaa  tacctcaaa  cagcaatac  agtctggcc  ctttttgca  caaagtaaa  900
aaaatcaga  aaagatatc  tgcagctga  gttaatttc  attctggga  gatctggag  960
actactaca  catttccgt  tcagctctt  tctaagacc  agtttaata  acatatttt  1020
attgataac  caacacaac  tcttcattt  atgccatgt  ctaattatc  tgtcaaaga  1080
ctaattgca  aaattctgc  tttttgcac  aatgaccag  tactcccca  agatcatat  1140
ctaagtgta  gtggctctg  agaattttt  caaaacgac  actgtttgg  gagccacaa  1200
atgtttcaa  aagataaat  tgttattca  ctccacctg  agaaaagta  ggaagctcc  1260
ggaaagcta  ctcgaaagc  tgaagagga  cacagtcag  tttatctga  tcaacttct  1320
gaatttatg  atatttgga  agtatccag  caatgtctc  taacactca  cagaaaata  1380
gacttccac  tgaaatacc  attgaaaac  caggaaaac  tgtataata  tattgaaga  1440
gttaaaaaa  tatgcagtg  tctagggtg  gtggaaacc  aacaaatta  agatgcagt  1500
aatgaacta  gtctaattc  tcagagaaa  ggagagaat  tttatcaaa  ttcagagac  1560
tcagcaaaa  gcttgatag  gaaggtaac  actgaacta  ccacatcca  ctaccagct  1620
atcaatgtc  actgtaaca  cttttatgc  gattttcag  ctgtaaatg  acctagatg  1680
acttcctat  taaatcccg  gcttccttc  cacctcagc  tcacagtgt  tgcagcaca  1740
aacattcca  aaacctggg  gcacaggat  aattttccc  ttgaaataa  gtcacttcc  1800
agggaatcc  tgctcactg  aaaactgtt  gggattgcc  gtgcaacca  caatgcaaa  1860
ttactggcg  ggacttgtc  tccactgtt  ccaaaagaa  aatccattc  cgggtctat  1920
ctgttcagc  tgacattac  gagtgagcc  cccgtagaa  tgataactc  aggagtgtg  1980
gatgtaagt  agccatccc  ggtgaccct  cagattgat  ttccagcta  tgggtggga  2040
tatatgaaa  ctgattctg  agagaatag  agtaatctt  aagagccac  aaaggagtg  2100
ataaaacat  ttgccagac  ttcacagaa  cagactccc  tactactct  tgaagaaaa  2160
aaaagatat  tatggtttt  tcgcttcta  tgcaataat  aaaactgct  ccttccttt  2220
gtcctgggt  gtgcccctg  atgggatga  aggactgtt  cagaaatgc  taccatttt  2280
agaagatgg  cattttctc  acctttaga  gctcttggg  ttttgactt  cagttttcc  2340
gatcaagaa  ttcgtaaag  ggcagttca  caattagac  acctcttga  tgatgaact  2400
ctggaatat  tcccacagc  agttcaggc  gtcaagttt  aatggaacc  tgagagtcc  2460
ttagtgcaa  ttctactcc  ccgctcctt  cagagcatc  aggttgccc  tcgtcttta  2520
tggctgcta  aaaatgcag  aaatgaagc  tattttaaa  gctggtatc  gaagctact  2580
gctgctctc  aattctgtg  aggtaaagc  ttgaatgat  agttttcca  ggagcagaa  2640
cttatcaaa  ttctgggag  tattgggga  agagtcaag  ctgccagtg  ccatcaaag  2700
caggaggta  tgaagaaag  aattggcag  ctagaagag  tctttcaag  tgtaaatac  2760
tgtcatctt  ctctgaacc  tgccctatg  ataaaaggg  ttgatcacg  tgcatgttc  2820
tattttaca  ctaatgctt  gccattgaa  attactttc  tcaatgcta  tctgatggg  2880
aaaaacatc  gcattattt  taaggctgg  gatgatctt  gtcaggata  gcttgttct  2940
cagcttatt  aagtgatgg  caatatttg  ctgcaggaa  gcttggata  gcaaatgat  3000
atttataga  gtctatcca  aggaaaaga  caacgattg  tgcagatgg  acctgatgc  3060
gtgacccta  caaagattc  tcgccattc  ggactgata  gaccattga  agaaaatac  3120
attaaaaag  ggttcagtc  gcacaacca  ttaaaggca  attatgaaa  ggccttgag  3180
aactttttc  actcctgtg  tggctggtg  gtggtaaca  tcatcctgg  agtatgtga  3240
cgtcacaat  ataatatca  gctgacaaa  tcgggccac  tgtttcata  tgactttgg  3300
aaattctta  gtcatgcac  aacatttgg  gggataaaa  gggaccgag  tcctttcat  3360
tttacttca  agatggaat  ctttattac  gagggtggg  aaaacccac  gcattttca  3420
gattttgtg  aactttgct  tcgtgctta  aatattatc  gaaagcaca  ccaactgct  3480
ttgaacctg  tggaaatga  gctgtatgc  ggactgcct  agctaagtg  aattcaaga  3540
ctgaaatat  tgtataata  tcttcgtcc  caagacaca  acctggaag  aacaagtca  3600
tttaccaag  aaataaagg  aagtctgga  tgtttccct  ttaaattga  taacttgat  3660
cacacactt  cacaaatgt  agccataag  cctgccaaa  ctacttcac  gacttttcc  3720
caggaatcc  gtttgctga  tacaactag  tcgattgaa  gagcaattt  agggttcag  3780
aagaaatcc  gtaatctgt  tctgatcca  gtgacacac  gcaacaacg  aacaagcct  3840
acagaaaaa  catttgagc  gttttcaaa  cttcacagc  aacttcaga  gcagtttgc  3900
tcactgact  tcccagagt  tcctcattg  tggcaccta  cttttacaa  ttcagatca  3960
agaagattc  gagatctaa  tcattacat  gaacagata  taaatgtat  acatgaagt  4020
acaaacagt  attgtgtac  tagcttttt  ctctctgag  ctgtgcaac  aacagttga  4080
tcatcacct  tgtacctag  tgagaagaa  tttccagac  agaagccta  ggtgcagtt  4140
gtcatatcc  acgaggatg  gaagctgac  atactagtg  aacacatga  aaacattca  4200
ctcccagat  gctctgcgc  cagtgcaca  gttgaattt  atcttttac  atatcccag  4260
gaagttctg  ggaggaaaa  aaaatctgt  ccaaaatgt  cggacccca  ttacaatga  4320
attgtagta  atgatgaag  cacagagct  caaggacat  tcttaatgc  tattgtgaa  4380
agtaaaact  tatttgtgg  agcaattaa  atccgactc  gtagtgtcc  actcgataa  4440
gaaaaatgg  atccattag  aaacagtat  atttcacca  tgctatgaa  atatgcatt  4500
ttcattaac  acttgtatt  tttcacttc  gggcctctg  atcacataa  taaggcatc  4560
ttgttgtca  agacagcac  gggtattaa  gacacagaa  aaaaatcag  attagtctt  4620
tgtgttgtt  attttctac  tgtgctttc  ttgtttttt  ataatcttt  ctccttcag  4680
ggagtactg  ttgcatgaa  tttgatgtg  aaaataata  aagaccttt  attaatcat  4740
ttaatatat  ttaaattaa  cataggttt  catttgttt  aattgtgtg  ctacagtta  4800
aagcagtat  tttaatgta  tttataaga  agacaatca  ataaacctc  tcaattaat  4860
caaaaaaaa  aaaaaaaaaa  4880



<210> 166
<211> 1448
<212> PRT
<213> Homo sapiens
<308> O75747
<400> 166

Met Ala Tyr Ser Trp Gln Thr Asp Pro Asn Pro Asn Glu Ser His Glu 
  1               5                  10                  15
Lys Gln Tyr Glu His Gln Glu Phe Leu Phe Val Asn Gln Pro His Ser 
             20                  25                  30
Ser Ser Gln Val Ser Leu Gly Phe Asp Gln Ile Val Asp Glu Ile Ser 
         35                  40                  45
Gly Lys Ile Pro His Tyr Glu Ser Glu Ile Asp Glu Asn Thr Phe Phe 
     50                  55                  60
Val Pro Thr Ala Pro Lys Trp Asp Ser Thr Gly His Ser Leu Asn Glu 
 65                  70                  75                  80
Ala His Gln Ile Ser Leu Asn Glu Phe Thr Ser Lys Ser Arg Glu Leu 
                 85                  90                  95
Ser Trp His Gln Val Ser Lys Ala Pro Ala Ile Gly Phe Ser Pro Ser 
             100                105                110
Val Leu Pro Lys Pro Gln Asn Thr Asn Lys Glu Cys Ser Trp Gly Ser 
         115                120                125
Pro Ile Gly Lys His His Gly Ala Asp Asp Ser Arg Phe Ser Ile Leu 
     130                135                140
Ala Pro Ser Phe Thr Ser Leu Asp Lys Ile Asn Leu Glu Lys Glu Leu 
 145                150                155                160
Glu Asn Glu Asn His Asn Tyr His Ile Gly Phe Glu Ser Ser Ile Pro 
                 165                170                175
Pro Thr Asn Ser Ser Phe Ser Ser Asp Phe Met Pro Lys Glu Glu Asn 
             180                185                190
Lys Arg Ser Gly His Val Asn Ile Val Glu Pro Ser Leu Met Leu Leu 
         195                200                205
Lys Gly Ser Leu Gln Pro Gly Met Trp Glu Ser Thr Trp Gln Lys Asn 
     210                215                220
Ile Glu Ser Ile Gly Cys Ser Ile Gln Leu Val Glu Val Pro Gln Ser 
 225                230                235                240
Ser Asn Thr Ser Leu Ala Ser Phe Cys Asn Lys Val Lys Lys Ile Arg 
                 245                250                255
Glu Arg Tyr His Ala Ala Asp Val Asn Phe Asn Ser Gly Lys Ile Trp 
             260                265                270
Ser Thr Thr Thr Ala Phe Pro Tyr Gln Leu Phe Ser Lys Thr Lys Phe 
         275                280                285
Asn Ile His Ile Phe Ile Asp Asn Ser Thr Gln Pro Leu His Phe Met 
     290                295                300
Pro Cys Ala Asn Tyr Leu Val Lys Asp Leu Ile Ala Glu Ile Leu His 
 305                310                315                320
Phe Cys Thr Asn Asp Gln Leu Leu Pro Lys Asp His Ile Leu Ser Val 
                 325                330                335
Cys Gly Ser Glu Glu Phe Leu Gln Asn Asp His Cys Leu Gly Ser His 
             340                345                350
Lys Met Phe Gln Lys Asp Lys Ser Val Ile Gln Leu His Leu Gln Lys 
         355                360                365
Ser Arg Glu Ala Pro Gly Lys Leu Ser Arg Lys His Glu Glu Asp His 
     370                375                380
Ser Gln Phe Tyr Leu Asn Gln Leu Leu Glu Phe Met His Ile Trp Lys 
 385                390                395                400
Val Ser Arg Gln Cys Leu Leu Thr Leu Ile Arg Lys Tyr Asp Phe His 
                 405                410                415
Leu Lys Tyr Leu Leu Lys Thr Gln Glu Asn Val Tyr Asn Ile Ile Glu 
             420                425                430
Glu Val Lys Lys Ile Cys Ser Val Leu Gly Cys Val Glu Thr Lys Gln 
         435                440                445
Ile Thr Asp Ala Val Asn Glu Leu Ser Leu Ile Leu Gln Arg Lys Gly 
     450                455                460
Glu Asn Phe Tyr Gln Ser Ser Glu Thr Ser Ala Lys Gly Leu Ile Glu 
 465                470                475                480
Lys Val Thr Thr Glu Leu Ser Thr Ser Ile Tyr Gln Leu Ile Asn Val 
                 485                490                495
Tyr Cys Asn Ser Phe Tyr Ala Asp Phe Gln Pro Val Asn Val Pro Arg 
             500                505                510
Cys Thr Ser Tyr Leu Asn Pro Gly Leu Pro Ser His Leu Ser Phe Thr 
         515                520                525
Val Tyr Ala Ala His Asn Ile Pro Glu Thr Trp Val His Arg Ile Asn 
     530                535                540
Phe Pro Leu Glu Ile Lys Ser Leu Pro Arg Glu Ser Met Leu Thr Val 
 545                550                555                560
Lys Leu Phe Gly Ile Ala Cys Ala Thr Asn Asn Ala Asn Leu Leu Ala 
                 565                570                575
Trp Thr Cys Leu Pro Leu Phe Pro Lys Glu Lys Ser Ile Leu Gly Ser 
             580                585                590
Met Leu Phe Ser Met Thr Leu Gln Ser Glu Pro Pro Val Glu Met Ile 
         595                600                605
Thr Pro Gly Val Trp Asp Val Ser Gln Pro Ser Pro Val Thr Leu Gln 
     610                615                620
Ile Asp Phe Pro Ala Thr Gly Trp Glu Tyr Met Lys Pro Asp Ser Glu 
 625                630                635                640
Glu Asn Arg Ser Asn Leu Glu Glu Pro Leu Lys Glu Cys Ile Lys His 
                 645                650                655
Ile Ala Arg Leu Ser Gln Lys Gln Thr Pro Leu Leu Leu Ser Glu Glu 
             660                665                670
Lys Lys Arg Tyr Leu Trp Phe Tyr Arg Phe Tyr Cys Asn Asn Glu Asn 
         675                680                685
Cys Ser Leu Pro Leu Val Leu Gly Ser Ala Pro Gly Trp Asp Glu Arg 
     690                695                700
Thr Val Ser Glu Met His Thr Ile Leu Arg Arg Trp Thr Phe Ser Gln 
 705                710                715                720
Pro Leu Glu Ala Leu Gly Leu Leu Thr Ser Ser Phe Pro Asp Gln Glu 
                 725                730                735
Ile Arg Lys Val Ala Val Gln Gln Leu Asp Asn Leu Leu Asn Asp Glu 
             740                745                750
Leu Leu Glu Tyr Leu Pro Gln Leu Val Gln Ala Val Lys Phe Glu Trp 
         755                760                765
Asn Leu Glu Ser Pro Leu Val Gln Leu Leu Leu His Arg Ser Leu Gln 
     770                775                780
Ser Ile Gln Val Ala His Arg Leu Tyr Trp Leu Leu Lys Asn Ala Glu 
 785                790                795                800
Asn Glu Ala Tyr Phe Lys Ser Trp Tyr Gln Lys Leu Leu Ala Ala Leu 
                 805                810                815
Gln Phe Cys Ala Gly Lys Ala Leu Asn Asp Glu Phe Ser Lys Glu Gln 
             820                825                830
Lys Leu Ile Lys Ile Leu Gly Asp Ile Gly Glu Arg Val Lys Ser Ala 
         835                840                845
Ser Asp His Gln Arg Gln Glu Val Leu Lys Lys Glu Ile Gly Arg Leu 
     850                855                860
Glu Glu Phe Phe Gln Asp Val Asn Thr Cys His Leu Pro Leu Asn Pro 
 865                870                875                880
Ala Leu Cys Ile Lys Gly Ile Asp His Asp Ala Cys Ser Tyr Phe Thr 
                 885                890                895
Ser Asn Ala Leu Pro Leu Lys Ile Thr Phe Ile Asn Ala Asn Leu Met 
             900                905                910
Gly Lys Asn Ile Ser Ile Ile Phe Lys Ala Gly Asp Asp Leu Arg Gln 
         915                920                925
Asp Met Leu Val Leu Gln Leu Ile Gln Val Met Asp Asn Ile Trp Leu 
     930                935                940
Gln Glu Gly Leu Asp Met Gln Met Ile Ile Tyr Arg Cys Leu Ser Thr 
 945                950                955                960
Gly Lys Asp Gln Arg Leu Val Gln Met Val Pro Asp Ala Val Thr Leu 
                 965                970                975
Ala Lys Ile His Arg His Ser Gly Leu Ile Gly Pro Leu Lys Glu Asn 
             980                985                990
Thr Ile Lys Lys Trp Phe Ser Gln His Asn His Leu Lys Ala Asp Tyr 
         995                1000                1005
Glu Lys Ala Leu Arg Asn Phe Phe Tyr Ser Cys Ala Gly Trp Cys Val 
     1010                1015                1020
Val Thr Phe Ile Leu Gly Val Cys Asp Arg His Asn Asp Asn Ile Met 
 1025                1030                1035                1040
Leu Thr Lys Ser Gly His Met Phe His Ile Asp Phe Gly Lys Phe Leu 
                 1045                1050                1055
Gly His Ala Gln Thr Phe Gly Gly Ile Lys Arg Asp Arg Ala Pro Phe 
             1060                1065                1070
Ile Phe Thr Ser Glu Met Glu Tyr Phe Ile Thr Glu Gly Gly Lys Asn 
         1075                1080                1085
Pro Gln His Phe Gln Asp Phe Val Glu Leu Cys Cys Arg Ala Tyr Asn 
     1090                1095                1100
Ile Ile Arg Lys His Ser Gln Leu Leu Leu Asn Leu Leu Glu Met Met 
 1105                1110                1115                1120
Leu Tyr Ala Gly Leu Pro Glu Leu Ser Gly Ile Gln Asp Leu Lys Tyr 
                 1125                1130                1135
Val Tyr Asn Asn Leu Arg Pro Gln Asp Thr Asp Leu Glu Ala Thr Ser 
             1140                1145                1150
His Phe Thr Lys Lys Ile Lys Glu Ser Leu Glu Cys Phe Pro Val Lys 
         1155                1160                1165
Leu Asn Asn Leu Ile His Thr Leu Ala Gln Met Ser Ala Ile Ser Pro 
     1170                1175                1180
Ala Lys Ser Thr Ser Gln Thr Phe Pro Gln Glu Ser Cys Leu Leu Ser 
 1185                1190                1195                1200
Thr Thr Arg Ser Ile Glu Arg Ala Ile Leu Gly Phe Ser Lys Lys Ser 
                 1205                1210                1215
Ser Asn Leu Tyr Leu Ile Gln Val Thr His Ser Asn Asn Glu Thr Ser 
             1220                1225                1230
Leu Thr Glu Lys Ser Phe Glu Gln Phe Ser Lys Leu His Ser Gln Leu 
         1235                1240                1245
Gln Lys Gln Phe Ala Ser Leu Thr Leu Pro Glu Phe Pro His Trp Trp 
     1250                1255                1260
His Leu Pro Phe Thr Asn Ser Asp His Arg Arg Phe Arg Asp Leu Asn 
 1265                1270                1275                1280
His Tyr Met Glu Gln Ile Leu Asn Val Ser His Glu Val Thr Asn Ser 
                 1285                1290                1295
Asp Cys Val Leu Ser Phe Phe Leu Ser Glu Ala Val Gln Gln Thr Val 
             1300                1305                1310
Glu Ser Ser Pro Val Tyr Leu Gly Glu Lys Lys Phe Pro Asp Lys Lys 
         1315                1320                1325
Pro Lys Val Gln Leu Val Ile Ser Tyr Glu Asp Val Lys Leu Thr Ile 
     1330                1335                1340
Leu Val Lys His Met Lys Asn Ile His Leu Pro Asp Gly Ser Ala Pro 
 1345                1350                1355                1360
Ser Ala His Val Glu Phe Tyr Leu Leu Pro Tyr Pro Ser Glu Val Leu 
                 1365                1370                1375
Arg Arg Lys Thr Lys Ser Val Pro Lys Cys Thr Asp Pro Thr Tyr Asn 
             1380                1385                1390
Glu Ile Val Val Tyr Asp Glu Val Thr Glu Leu Gln Gly His Val Leu 
         1395                1400                1405
Met Leu Ile Val Lys Ser Lys Thr Val Phe Val Gly Ala Ile Asn Ile 
     1410                1415                1420
Arg Leu Cys Ser Val Pro Leu Asp Lys Glu Lys Trp Tyr Pro Leu Gly 
 1425                1430                1435                1440
Asn Ser Ile Ile Ser Pro Leu Leu 
                 1445



<210> 167
<211> 3732
<212> DNA
<213> Rattus norvegicus
<308> AB009999
<400> 167

tgacatgct  gagctgcgg  accgcgggg  ctgccccgg  cccggggga  cggggacgc  60
gccaccccg  gagggagag  cggccggcg  cgaccacga  accgagagc  ccagcgaca  120
agaaacaga  attgatgac  ggtatggag  tctcgatgc  agaggagat  ccgatgttc  180
tgaggtccc  ccatcctca  acaggaccc  cgagattct  aagaaagcc  tgtctggac  240
gtcatcaag  tggaagaac  ggtggattc  tgggatcct  accctgacc  tgatctccc  300
cttcttcct  atcatctat  tggggtcct  catgctgat  cttctggtt  tgggcatcc  360
ggtgaagtg  ttccaggag  tcataacca  cgggtacag  gtctaccac  cctacgacc  420
cccgtggtt  agaacacta  gttggtact  cctcctatg  gtgaactac  tcttctatg  480
agagacagt  gcagattac  tcgccacgt  cgttcagaa  gaggagcag  tgcagttcc  540
cattcgcta  cacaggttc  tatccttcg  cctctacct  gcaggtttc  gcatgttcg  600
cctgagctt  gtgaagaaa  actaccgac  acagttcta  atgttcgca  ggactcacg  660
cactttact  ataaccgtc  ctcagtcac  tcttgtcat  caaaatctg  ttgaaggca  720
gatatggtt  cttgtcccc  tatcaagcg  catctgcaa  gatatcacg  cttaccttt  780
tggattttt  tttggaaga  ctcctttaa  taagctgtc  cctaagaag  cctgggaag  840
attcattgg  ggtttcttc  ccacagtca  atttggatt  attgctgcc  atgtgttgt  900
caagtatca  tactttgtg  gcccggtgg  gtaccgaag  gacgtcaac  ccttcgtga  960
agaatgtga  ccctcagaa  tgttccagc  tcagaatta  tccctccct  cgttcctac  1020
ggcagtgct  agccgggag  ccgtgagct  gtacccctt  cagatacac  gcattgccc  1080
ttcaacatt  gcatcactg  tcggcccat  cggaggctt  ttcgccagt  gattcaaaa  1140
agctttcaa  atcaaggac  ttgcaaaca  tattcctgg  catggaggg  taatggaca  1200
gttcgattg  cagtatttg  tggcgacgt  cgtgcacgt  tacatcacc  gcttcatca  1260
gggtccgaa  cccagcaaa  tgctccagc  gctcctagt  cttcagcca  agcagcagt  1320
aaacatcta  agaaccctg  agatacatc  cacggagaa  ggcatcctg  agcccacct  1380
gaaggtgta  ctgtcctga  gggacagac  gctgaggag  aaggagctc  cagagcagc  1440
ccgactgaa  tcttgcact  agccagcct  gggctagaa  ctcagtaga  gcaggtttt  1500
cagatacga  tgtttctct  tctctgaaa  tactgtgaa  atttaacaa  cacgagatc  1560
gagacgagt  cgcatcagt  gccgccgtg  aagatccgt  cttttctaa  atgtatttt  1620
caatgttaa  ttctccgcc  ttactggcc  ggctccatg  tgtaggagg  ttaaagagt  1680
aagcactgt  acctgaggc  gaggccccc  taggctcgt  cctggcagt  tgatccttc  1740
cacaaacac  gacctttgc  ctgactggg  gctgcctct  tgtggctgg  gatgctcag  1800
aggcaccct  ggaagcgag  cctagggct  cctcctcta  tgacctcag  catttctgc  1860
ggctgagtt  gattaaaaa  gaaagaaaa  gagcgcttg  ccacttctc  ctcttcttt  1920
tgtttgttt  tacacacca  gcaggcgcc  cactcctag  ctctgttcc  gctggaccg  1980
ctgcctact  tcagagaaa  agccatctg  ccagtggaa  caccctggt  ttaagtagt  2040
tcaaaccaa  aggtagagg  tgaaactta  cccactatt  atttgttta  aaagaaggc  2100
tcagaatcc  tctctgatg  aacttttgg  gaagcacgt  accaacttc  caagagact  2160
aggagtggg  cctgctcct  caccaaaac  cctcaccca  gacggtggt  ctgtgagca  2220
gggtggagg  tgagtcggc  ggctgcctg  ggtgagctg  gcactgcat  gcggtgcca  2280
gcctgcctc  atctctgtg  acagcacac  tggagacga  ggttttccc  gaagaccca  2340
ctcagagcc  gccccctga  ggcaattaa  ctctgtcac  ttgcacttc  tgtcatgcc  2400
tgaaaacca  gagtaaaga  caagcagaa  taatagcca  gaagcagaa  agcacagga  2460
agccacgcc  tcttctgta  gtgggcagg  cactgtaaa  actctagcc  atcacagca  2520
cgttgttaa  taagctgcc  ccaagtgtg  tctgcagcc  tattgaacc  aatgtcagg  2580
tcacccgca  agatgacct  gttccccaa  ctcagcacc  agaggtgga  aaatggaga  2640
accataaag  ataatttgg  catgaaaga  taaatattt  tgtttaaat  agaaatgga  2700
tccagtcac  acatttcct  cccagtgtg  atgaaccca  agccatcct  ggctctgta  2760
gcacatggc  tatgtgtga  catggcaga  gctgtggtc  tcagtccca  aatgccact  2820
ttggcccct  ggtgacttg  gaccctggg  tccattcag  ctgtgtcct  tgcacgcag  2880
cagccgagg  agcattggc  acattacag  gactccctc  cagtcagga  accggggag  2940
tgatgtcag  ttccctgct  ttgtttgtc  ctcgccctg  cccagaagt  gaccatgac  3000
cagttgcag  caccgagga  gctgagaga  gccttgtga  aggatcatt  cccgagaac  3060
gggcagttt  caaaggtgt  aaggatgcc  ggggacagg  tggattctc  ttacccacc  3120
tgctgtcca  gcgtcgtga  gggttgcga  gcagaatta  gagagcatt  cttaataca  3180
gtattaaaa  tcaatattc  tctaaacaa  ggatgaaag  aggttacgg  aaaagcttt  3240
cttaaatag  ttttcttag  gctgggtgt  cattacgcc  tattaaaac  agggcgttc  3300
ctgacaacg  cctagagat  aacatttta  cgtactttc  cagcgtgta  attaaagtg  3360
actatactt  agcaagcaa  catcctaag  gccatgtga  gagcgctac  tttgcactg  3420
aagaagctt  atccagcgg  gtgacgcag  ggacaaatg  caggccctc  aggcgggga  3480
ccttcagtg  aaaactgcc  cttgaactg  tgctgactt  ttagcccgt  ggatgatga  3540
gtccgagaa  ggggcgttc  ccccagcct  ccttgtggg  ttgcacaga  agttgctgt  3600
atggcgaca  ctggtttga  gaaaggtcg  ggcgctgtg  atatactgt  cagggtgag  3660
gtttatgat  cgtgtcaat  agttctcta  atctttata  tgaaactgg  atagaaaaa  3720
aaaaatcca  ca  3732



<210> 168
<211> 461
<212> PRT
<213> Rattus norvegicus
<308> O35052
<400> 168

Met Leu Glu Leu Arg His Arg Gly Gly Cys Pro Gly Pro Gly Gly Ala 
  1               5                  10                  15
Gly Thr Pro Pro Pro Arg Glu Gly Glu Ala Ala Gly Gly Asp His Glu 
             20                  25                  30
Thr Glu Ser Thr Ser Asp Lys Glu Thr Asp Ile Asp Asp Arg Tyr Gly 
         35                  40                  45
Asp Leu Asp Ala Arg Gly Asp Ser Asp Val Pro Glu Val Pro Pro Ser 
     50                  55                  60
Ser Asp Arg Thr Pro Glu Ile Leu Lys Lys Ala Leu Ser Gly Leu Ser 
 65                  70                  75                  80
Ser Arg Trp Lys Asn Trp Trp Ile Arg Gly Ile Leu Thr Leu Thr Met 
                 85                  90                  95
Ile Ser Leu Phe Phe Leu Ile Ile Tyr Met Gly Ser Phe Met Leu Met 
             100                105                110
Leu Leu Val Leu Gly Ile Gln Val Lys Cys Phe Gln Glu Ile Ile Thr 
         115                120                125
Ile Gly Tyr Arg Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Thr 
     130                135                140
Leu Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe Phe Tyr Gly Glu 
 145                150                155                160
Thr Val Ala Asp Tyr Phe Ala Thr Phe Val Gln Arg Glu Glu Gln Leu 
                 165                170                175
Gln Phe Leu Ile Arg Tyr His Arg Phe Ile Ser Phe Ala Leu Tyr Leu 
             180                185                190
Ala Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg 
         195                200                205
Leu Gln Phe Tyr Met Phe Ala Trp Thr His Val Thr Leu Leu Ile Thr 
     210                215                220
Val Thr Gln Ser His Leu Val Ile Gln Asn Leu Phe Glu Gly Met Ile 
 225                230                235                240
Trp Phe Leu Val Pro Ile Ser Ser Val Ile Cys Asn Asp Ile Thr Ala 
                 245                250                255
Tyr Leu Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu Ile Lys Leu Ser 
             260                265                270
Pro Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe Phe Ser Thr Val 
         275                280                285
Ile Phe Gly Phe Ile Ala Ala Tyr Val Leu Ser Lys Tyr Gln Tyr Phe 
     290                295                300
Val Cys Pro Val Glu Tyr Arg Ser Asp Val Asn Ser Phe Val Thr Glu 
 305                310                315                320
Cys Glu Pro Ser Glu Leu Phe Gln Leu Gln Asn Tyr Ser Leu Pro Pro 
                 325                330                335
Phe Leu Gln Ala Val Leu Ser Arg Glu Thr Val Ser Leu Tyr Pro Phe 
             340                345                350
Gln Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser Leu Ile Gly Pro 
         355                360                365
Phe Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys 
     370                375                380
Asp Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe 
 385                390                395                400
Asp Cys Gln Tyr Leu Met Ala Thr Phe Val His Val Tyr Ile Thr Ser 
                 405                410                415
Phe Ile Arg Gly Pro Asn Pro Ser Lys Val Leu Gln Gln Leu Leu Val 
             420                425                430
Leu Gln Pro Glu Gln Gln Leu Asn Ile Tyr Arg Thr Leu Lys Ile His 
         435                440                445
Leu Thr Glu Lys Gly Ile Leu Gln Pro Thr Trp Lys Val 
     450                455                460



<210> 169
<211> 2356
<212> DNA
<213> Homo sapiens
<308> U65887
<400> 169

gaattcggc  cgagcgggg  gggaggggc  tgcgcggcg  cgggagccc  gagccgcgc  60
aaagcgggt  aagcgtcct  cttttctcc  cgccccttc  cctcctcct  cctgggcct  120
tgcgtggag  cgcgcacct  gcaaccgga  gccgcgtct  cgccttctc  gctcgcgcc  180
ggcgcccgg  gcctgcccg  gacctccgc  ggagccgcg  tcgctgcag  cggcctcga  240
cgctctctc  ttgatgccg  tttggaggt  accggcgcg  cggccgctc  atggtgggg  300
cgcgttagt  gctgcggct  cgcgggact  cagggcgcg  ctgcgaggt  gcggggcgc  360
ccgcctgca  aaccctgct  gcagctcag  tttcggggt  cttgaggag  ccgccacgg  420
agcgcggga  cggaagatg  tggagctga  gcaccgggg  agctgcccc  gccccaggg  480
agcggtgtc  ccgccacac  gcgagggag  ggcggccgg  ggcgaccac  aaaccgaga  540
caccagcga  aaagaaaca  atattgatg  cagatatgg  gatttggat  ccagaacag  600
ttctgatat  ccggaaatt  caccatcct  agatagaac  cctgagatt  tcaaaaaag  660
tctatctgg  ttatcttca  ggtggaaaa  ctggtggat  cgtggaatt  tcactctaa  720
tatgatctc  ttgtttttc  tgatcatct  tatgggatc  ttcatgctg  tgcttcttg  780
tctgggcat  caagtgaaa  gcttccatg  aattatcac  ataggttat  gagtctatc  840
ttcttatga  ctaccatgg  ttagaacac  aagttggta  tttctattg  gtgtaaact  900
ctttttcta  ggagagact  tagctgatt  ttttgctac  tttgttcaa  gagaagaac  960
acttcagtt  ctcattcgc  accatagat  tatatcatt  gccctctat  tggcaggtt  1020
ctgcatgtt  gtactgagt  tggtgaaga  acattatcg  ctgcagttt  atatgttcg  1080
atggactca  gtcacttta  tgataactg  cactcagtc  caccttgtc  tccaaaatc  1140
gtttgaagg  atgatatgg  tccttgttc  aatatcaag  gttatctgc  atgacataa  1200
tgcttacct  tttggattt  tttttggga  aactccatt  attaagttg  ctcctaaaa  1260
gacttggga  ggattcatt  gtggtttct  ttccacagt  gtgtttgga  tcattgctg  1320
ctatgtgtt  tccaaatac  agtactttg  ctgcccagt  gaataccga  gtgatgtaa  1380
ctccttcgt  acagaatgt  agccctcag  acttttcca  cttcagact  actcacttc  1440
accctttct  aaggcagtc  tgagacagg  aagagtgag  ttgtaccct  tccagatcc  1500
cagcattgc  ctgtcaacc  ttgcatctt  aattggccc  tttggaggc  tctttgcta  1560
tggattcaa  agagccttc  aaatcaagg  ttttgcaaa  accattcct  gacatggtg  1620
gataatgga  agatttgat  gtcagtatt  gatggcaac  tttgtacat  tgtacatca  1680
aagttttat  cggggccca  atcccagca  agtgctaca  cagttgttg  tgcttcaac  1740
tgaacagca  ttaaatata  ataaaccct  aagactcat  tcattgaga  aggatccta  1800
aacccacct  gaaggtata  ctggatcca  agagggaag  actgacaag  aggaattat  1860
cagaaaaac  ctgacagat  ttttataaa  tgtacagaa  aatagttaa  aatgcaata  1920
gttgaagtt  tccagatat  tttctctct  aaattactg  gaatattta  caaacactt  1980
cttgatcta  gttatgaaa  aagtagcaa  ttgccagca  aatgtcttg  accttttct  2040
aagtgtatt  tctgatgtg  acttccttc  ccttacttg  taggtttca  taatttaaa  2100
gagtcaaac  ctataaatg  gtaagttga  gatgtttta  gattgcacc  ggcagtgtg  2160
ctttttgca  caaatattt  cctggcagt  tgccttttt  caacaaata  ttactttgc  2220
cttggagct  cttttaatt  tagcaaaat  ttttatgca  ggcacaata  gaagtcagt  2280
ctcctgcac  tcctcctca  gtagtctgg  gtactttct  aagggctta  ttggattta  2340
aaaaaaaaa  aaaaaa  2356



<210> 170
<211> 461
<212> PRT
<213> Homo sapiens
<308> Q92903
<400> 170

Met Leu Glu Leu Arg His Arg Gly Ser Cys Pro Gly Pro Arg Glu Ala 
  1               5                  10                  15
Val Ser Pro Pro His Arg Glu Gly Glu Ala Ala Gly Gly Asp His Glu 
             20                  25                  30
Thr Glu Ser Thr Ser Asp Lys Glu Thr Asp Ile Asp Asp Arg Tyr Gly 
         35                  40                  45
Asp Leu Asp Ser Arg Thr Asp Ser Asp Ile Pro Glu Ile Pro Pro Ser 
     50                  55                  60
Ser Asp Arg Thr Pro Glu Ile Leu Lys Lys Ala Leu Ser Gly Leu Ser 
 65                  70                  75                  80
Ser Arg Trp Lys Asn Trp Trp Ile Arg Gly Ile Leu Thr Leu Thr Met 
                 85                  90                  95
Ile Ser Leu Phe Phe Leu Ile Ile Tyr Met Gly Ser Phe Met Leu Met 
             100                105                110
Leu Leu Val Leu Gly Ile Gln Val Lys Cys Phe His Glu Ile Ile Thr 
         115                120                125
Ile Gly Tyr Arg Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Thr 
     130                135                140
Leu Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe Phe Tyr Gly Glu 
 145                150                155                160
Thr Val Ala Asp Tyr Phe Ala Thr Phe Val Gln Arg Glu Glu Gln Leu 
                 165                170                175
Gln Phe Leu Ile Arg Tyr His Arg Phe Ile Ser Phe Ala Leu Tyr Leu 
             180                185                190
Ala Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg 
         195                200                205
Leu Gln Phe Tyr Met Phe Ala Trp Thr His Val Thr Leu Leu Ile Thr 
     210                215                220
Val Thr Gln Ser His Leu Val Ile Gln Asn Leu Phe Glu Gly Met Ile 
 225                230                235                240
Trp Phe Leu Val Pro Ile Ser Ser Val Ile Cys Asn Asp Ile Thr Ala 
                 245                250                255
Tyr Leu Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu Ile Lys Leu Ser 
             260                265                270
Pro Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe Phe Ser Thr Val 
         275                280                285
Val Phe Gly Phe Ile Ala Ala Tyr Val Leu Ser Lys Tyr Gln Tyr Phe 
     290                295                300
Val Cys Pro Val Glu Tyr Arg Ser Asp Val Asn Ser Phe Val Thr Glu 
 305                310                315                320
Cys Glu Pro Ser Glu Leu Phe Gln Leu Gln Thr Tyr Ser Leu Pro Pro 
                 325                330                335
Phe Leu Lys Ala Val Leu Arg Gln Glu Arg Val Ser Leu Tyr Pro Phe 
             340                345                350
Gln Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser Leu Ile Gly Pro 
         355                360                365
Phe Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys 
     370                375                380
Asp Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe 
 385                390                395                400
Asp Cys Gln Tyr Leu Met Ala Thr Phe Val His Val Tyr Ile Thr Ser 
                 405                410                415
Phe Ile Arg Gly Pro Asn Pro Ser Lys Val Leu Gln Gln Leu Leu Val 
             420                425                430
Leu Gln Pro Glu Gln Gln Leu Asn Ile Tyr Lys Thr Leu Lys Thr His 
         435                440                445
Leu Ile Glu Lys Gly Ile Leu Gln Pro Thr Leu Lys Val 
     450                455                460



<210> 171
<211> 3732
<212> DNA
<213> Rattus norvegicus
<308> AB009999
<400> 171

tgacatgct  gagctgcgg  accgcgggg  ctgccccgg  cccggggga  cggggacgc  60
gccaccccg  gagggagag  cggccggcg  cgaccacga  accgagagc  ccagcgaca  120
agaaacaga  attgatgac  ggtatggag  tctcgatgc  agaggagat  ccgatgttc  180
tgaggtccc  ccatcctca  acaggaccc  cgagattct  aagaaagcc  tgtctggac  240
gtcatcaag  tggaagaac  ggtggattc  tgggatcct  accctgacc  tgatctccc  300
cttcttcct  atcatctat  tggggtcct  catgctgat  cttctggtt  tgggcatcc  360
ggtgaagtg  ttccaggag  tcataacca  cgggtacag  gtctaccac  cctacgacc  420
cccgtggtt  agaacacta  gttggtact  cctcctatg  gtgaactac  tcttctatg  480
agagacagt  gcagattac  tcgccacgt  cgttcagaa  gaggagcag  tgcagttcc  540
cattcgcta  cacaggttc  tatccttcg  cctctacct  gcaggtttc  gcatgttcg  600
cctgagctt  gtgaagaaa  actaccgac  acagttcta  atgttcgca  ggactcacg  660
cactttact  ataaccgtc  ctcagtcac  tcttgtcat  caaaatctg  ttgaaggca  720
gatatggtt  cttgtcccc  tatcaagcg  catctgcaa  gatatcacg  cttaccttt  780
tggattttt  tttggaaga  ctcctttaa  taagctgtc  cctaagaag  cctgggaag  840
attcattgg  ggtttcttc  ccacagtca  atttggatt  attgctgcc  atgtgttgt  900
caagtatca  tactttgtg  gcccggtgg  gtaccgaag  gacgtcaac  ccttcgtga  960
agaatgtga  ccctcagaa  tgttccagc  tcagaatta  tccctccct  cgttcctac  1020
ggcagtgct  agccgggag  ccgtgagct  gtacccctt  cagatacac  gcattgccc  1080
ttcaacatt  gcatcactg  tcggcccat  cggaggctt  ttcgccagt  gattcaaaa  1140
agctttcaa  atcaaggac  ttgcaaaca  tattcctgg  catggaggg  taatggaca  1200
gttcgattg  cagtatttg  tggcgacgt  cgtgcacgt  tacatcacc  gcttcatca  1260
gggtccgaa  cccagcaaa  tgctccagc  gctcctagt  cttcagcca  agcagcagt  1320
aaacatcta  agaaccctg  agatacatc  cacggagaa  ggcatcctg  agcccacct  1380
gaaggtgta  ctgtcctga  gggacagac  gctgaggag  aaggagctc  cagagcagc  1440
ccgactgaa  tcttgcact  agccagcct  gggctagaa  ctcagtaga  gcaggtttt  1500
cagatacga  tgtttctct  tctctgaaa  tactgtgaa  atttaacaa  cacgagatc  1560
gagacgagt  cgcatcagt  gccgccgtg  aagatccgt  cttttctaa  atgtatttt  1620
caatgttaa  ttctccgcc  ttactggcc  ggctccatg  tgtaggagg  ttaaagagt  1680
aagcactgt  acctgaggc  gaggccccc  taggctcgt  cctggcagt  tgatccttc  1740
cacaaacac  gacctttgc  ctgactggg  gctgcctct  tgtggctgg  gatgctcag  1800
aggcaccct  ggaagcgag  cctagggct  cctcctcta  tgacctcag  catttctgc  1860
ggctgagtt  gattaaaaa  gaaagaaaa  gagcgcttg  ccacttctc  ctcttcttt  1920
tgtttgttt  tacacacca  gcaggcgcc  cactcctag  ctctgttcc  gctggaccg  1980
ctgcctact  tcagagaaa  agccatctg  ccagtggaa  caccctggt  ttaagtagt  2040
tcaaaccaa  aggtagagg  tgaaactta  cccactatt  atttgttta  aaagaaggc  2100
tcagaatcc  tctctgatg  aacttttgg  gaagcacgt  accaacttc  caagagact  2160
aggagtggg  cctgctcct  caccaaaac  cctcaccca  gacggtggt  ctgtgagca  2220
gggtggagg  tgagtcggc  ggctgcctg  ggtgagctg  gcactgcat  gcggtgcca  2280
gcctgcctc  atctctgtg  acagcacac  tggagacga  ggttttccc  gaagaccca  2340
ctcagagcc  gccccctga  ggcaattaa  ctctgtcac  ttgcacttc  tgtcatgcc  2400
tgaaaacca  gagtaaaga  caagcagaa  taatagcca  gaagcagaa  agcacagga  2460
agccacgcc  tcttctgta  gtgggcagg  cactgtaaa  actctagcc  atcacagca  2520
cgttgttaa  taagctgcc  ccaagtgtg  tctgcagcc  tattgaacc  aatgtcagg  2580
tcacccgca  agatgacct  gttccccaa  ctcagcacc  agaggtgga  aaatggaga  2640
accataaag  ataatttgg  catgaaaga  taaatattt  tgtttaaat  agaaatgga  2700
tccagtcac  acatttcct  cccagtgtg  atgaaccca  agccatcct  ggctctgta  2760
gcacatggc  tatgtgtga  catggcaga  gctgtggtc  tcagtccca  aatgccact  2820
ttggcccct  ggtgacttg  gaccctggg  tccattcag  ctgtgtcct  tgcacgcag  2880
cagccgagg  agcattggc  acattacag  gactccctc  cagtcagga  accggggag  2940
tgatgtcag  ttccctgct  ttgtttgtc  ctcgccctg  cccagaagt  gaccatgac  3000
cagttgcag  caccgagga  gctgagaga  gccttgtga  aggatcatt  cccgagaac  3060
gggcagttt  caaaggtgt  aaggatgcc  ggggacagg  tggattctc  ttacccacc  3120
tgctgtcca  gcgtcgtga  gggttgcga  gcagaatta  gagagcatt  cttaataca  3180
gtattaaaa  tcaatattc  tctaaacaa  ggatgaaag  aggttacgg  aaaagcttt  3240
cttaaatag  ttttcttag  gctgggtgt  cattacgcc  tattaaaac  agggcgttc  3300
ctgacaacg  cctagagat  aacatttta  cgtactttc  cagcgtgta  attaaagtg  3360
actatactt  agcaagcaa  catcctaag  gccatgtga  gagcgctac  tttgcactg  3420
aagaagctt  atccagcgg  gtgacgcag  ggacaaatg  caggccctc  aggcgggga  3480
ccttcagtg  aaaactgcc  cttgaactg  tgctgactt  ttagcccgt  ggatgatga  3540
gtccgagaa  ggggcgttc  ccccagcct  ccttgtggg  ttgcacaga  agttgctgt  3600
atggcgaca  ctggtttga  gaaaggtcg  ggcgctgtg  atatactgt  cagggtgag  3660
gtttatgat  cgtgtcaat  agttctcta  atctttata  tgaaactgg  atagaaaaa  3720
aaaaatcca  ca  3732



<210> 172
<211> 461
<212> PRT
<213> Rattus norvegicus
<308> O35052
<400> 172

Met Leu Glu Leu Arg His Arg Gly Gly Cys Pro Gly Pro Gly Gly Ala 
  1               5                  10                  15
Gly Thr Pro Pro Pro Arg Glu Gly Glu Ala Ala Gly Gly Asp His Glu 
             20                  25                  30
Thr Glu Ser Thr Ser Asp Lys Glu Thr Asp Ile Asp Asp Arg Tyr Gly 
         35                  40                  45
Asp Leu Asp Ala Arg Gly Asp Ser Asp Val Pro Glu Val Pro Pro Ser 
     50                  55                  60
Ser Asp Arg Thr Pro Glu Ile Leu Lys Lys Ala Leu Ser Gly Leu Ser 
 65                  70                  75                  80
Ser Arg Trp Lys Asn Trp Trp Ile Arg Gly Ile Leu Thr Leu Thr Met 
                 85                  90                  95
Ile Ser Leu Phe Phe Leu Ile Ile Tyr Met Gly Ser Phe Met Leu Met 
             100                105                110
Leu Leu Val Leu Gly Ile Gln Val Lys Cys Phe Gln Glu Ile Ile Thr 
         115                120                125
Ile Gly Tyr Arg Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Thr 
     130                135                140
Leu Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe Phe Tyr Gly Glu 
 145                150                155                160
Thr Val Ala Asp Tyr Phe Ala Thr Phe Val Gln Arg Glu Glu Gln Leu 
                 165                170                175
Gln Phe Leu Ile Arg Tyr His Arg Phe Ile Ser Phe Ala Leu Tyr Leu 
             180                185                190
Ala Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg 
         195                200                205
Leu Gln Phe Tyr Met Phe Ala Trp Thr His Val Thr Leu Leu Ile Thr 
     210                215                220
Val Thr Gln Ser His Leu Val Ile Gln Asn Leu Phe Glu Gly Met Ile 
 225                230                235                240
Trp Phe Leu Val Pro Ile Ser Ser Val Ile Cys Asn Asp Ile Thr Ala 
                 245                250                255
Tyr Leu Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu Ile Lys Leu Ser 
             260                265                270
Pro Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe Phe Ser Thr Val 
         275                280                285
Ile Phe Gly Phe Ile Ala Ala Tyr Val Leu Ser Lys Tyr Gln Tyr Phe 
     290                295                300
Val Cys Pro Val Glu Tyr Arg Ser Asp Val Asn Ser Phe Val Thr Glu 
 305                310                315                320
Cys Glu Pro Ser Glu Leu Phe Gln Leu Gln Asn Tyr Ser Leu Pro Pro 
                 325                330                335
Phe Leu Gln Ala Val Leu Ser Arg Glu Thr Val Ser Leu Tyr Pro Phe 
             340                345                350
Gln Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser Leu Ile Gly Pro 
         355                360                365
Phe Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys 
     370                375                380
Asp Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe 
 385                390                395                400
Asp Cys Gln Tyr Leu Met Ala Thr Phe Val His Val Tyr Ile Thr Ser 
                 405                410                415
Phe Ile Arg Gly Pro Asn Pro Ser Lys Val Leu Gln Gln Leu Leu Val 
             420                425                430
Leu Gln Pro Glu Gln Gln Leu Asn Ile Tyr Arg Thr Leu Lys Ile His 
         435                440                445
Leu Thr Glu Lys Gly Ile Leu Gln Pro Thr Trp Lys Val 
     450                455                460



<210> 173
<211> 2356
<212> DNA
<213> Homo sapiens
<308> U65887
<400> 173

gaattcggc  cgagcgggg  gggaggggc  tgcgcggcg  cgggagccc  gagccgcgc  60
aaagcgggt  aagcgtcct  cttttctcc  cgccccttc  cctcctcct  cctgggcct  120
tgcgtggag  cgcgcacct  gcaaccgga  gccgcgtct  cgccttctc  gctcgcgcc  180
ggcgcccgg  gcctgcccg  gacctccgc  ggagccgcg  tcgctgcag  cggcctcga  240
cgctctctc  ttgatgccg  tttggaggt  accggcgcg  cggccgctc  atggtgggg  300
cgcgttagt  gctgcggct  cgcgggact  cagggcgcg  ctgcgaggt  gcggggcgc  360
ccgcctgca  aaccctgct  gcagctcag  tttcggggt  cttgaggag  ccgccacgg  420
agcgcggga  cggaagatg  tggagctga  gcaccgggg  agctgcccc  gccccaggg  480
agcggtgtc  ccgccacac  gcgagggag  ggcggccgg  ggcgaccac  aaaccgaga  540
caccagcga  aaagaaaca  atattgatg  cagatatgg  gatttggat  ccagaacag  600
ttctgatat  ccggaaatt  caccatcct  agatagaac  cctgagatt  tcaaaaaag  660
tctatctgg  ttatcttca  ggtggaaaa  ctggtggat  cgtggaatt  tcactctaa  720
tatgatctc  ttgtttttc  tgatcatct  tatgggatc  ttcatgctg  tgcttcttg  780
tctgggcat  caagtgaaa  gcttccatg  aattatcac  ataggttat  gagtctatc  840
ttcttatga  ctaccatgg  ttagaacac  aagttggta  tttctattg  gtgtaaact  900
ctttttcta  ggagagact  tagctgatt  ttttgctac  tttgttcaa  gagaagaac  960
acttcagtt  ctcattcgc  accatagat  tatatcatt  gccctctat  tggcaggtt  1020
ctgcatgtt  gtactgagt  tggtgaaga  acattatcg  ctgcagttt  atatgttcg  1080
atggactca  gtcacttta  tgataactg  cactcagtc  caccttgtc  tccaaaatc  1140
gtttgaagg  atgatatgg  tccttgttc  aatatcaag  gttatctgc  atgacataa  1200
tgcttacct  tttggattt  tttttggga  aactccatt  attaagttg  ctcctaaaa  1260
gacttggga  ggattcatt  gtggtttct  ttccacagt  gtgtttgga  tcattgctg  1320
ctatgtgtt  tccaaatac  agtactttg  ctgcccagt  gaataccga  gtgatgtaa  1380
ctccttcgt  acagaatgt  agccctcag  acttttcca  cttcagact  actcacttc  1440
accctttct  aaggcagtc  tgagacagg  aagagtgag  ttgtaccct  tccagatcc  1500
cagcattgc  ctgtcaacc  ttgcatctt  aattggccc  tttggaggc  tctttgcta  1560
tggattcaa  agagccttc  aaatcaagg  ttttgcaaa  accattcct  gacatggtg  1620
gataatgga  agatttgat  gtcagtatt  gatggcaac  tttgtacat  tgtacatca  1680
aagttttat  cggggccca  atcccagca  agtgctaca  cagttgttg  tgcttcaac  1740
tgaacagca  ttaaatata  ataaaccct  aagactcat  tcattgaga  aggatccta  1800
aacccacct  gaaggtata  ctggatcca  agagggaag  actgacaag  aggaattat  1860
cagaaaaac  ctgacagat  ttttataaa  tgtacagaa  aatagttaa  aatgcaata  1920
gttgaagtt  tccagatat  tttctctct  aaattactg  gaatattta  caaacactt  1980
cttgatcta  gttatgaaa  aagtagcaa  ttgccagca  aatgtcttg  accttttct  2040
aagtgtatt  tctgatgtg  acttccttc  ccttacttg  taggtttca  taatttaaa  2100
gagtcaaac  ctataaatg  gtaagttga  gatgtttta  gattgcacc  ggcagtgtg  2160
ctttttgca  caaatattt  cctggcagt  tgccttttt  caacaaata  ttactttgc  2220
cttggagct  cttttaatt  tagcaaaat  ttttatgca  ggcacaata  gaagtcagt  2280
ctcctgcac  tcctcctca  gtagtctgg  gtactttct  aagggctta  ttggattta  2340
aaaaaaaaa  aaaaaa  2356



<210> 174
<211> 461
<212> PRT
<213> Homo sapiens
<308> Q92903
<400> 174

Met Leu Glu Leu Arg His Arg Gly Ser Cys Pro Gly Pro Arg Glu Ala 
  1               5                  10                  15
Val Ser Pro Pro His Arg Glu Gly Glu Ala Ala Gly Gly Asp His Glu 
             20                  25                  30
Thr Glu Ser Thr Ser Asp Lys Glu Thr Asp Ile Asp Asp Arg Tyr Gly 
         35                  40                  45
Asp Leu Asp Ser Arg Thr Asp Ser Asp Ile Pro Glu Ile Pro Pro Ser 
     50                  55                  60
Ser Asp Arg Thr Pro Glu Ile Leu Lys Lys Ala Leu Ser Gly Leu Ser 
 65                  70                  75                  80
Ser Arg Trp Lys Asn Trp Trp Ile Arg Gly Ile Leu Thr Leu Thr Met 
                 85                  90                  95
Ile Ser Leu Phe Phe Leu Ile Ile Tyr Met Gly Ser Phe Met Leu Met 
             100                105                110
Leu Leu Val Leu Gly Ile Gln Val Lys Cys Phe His Glu Ile Ile Thr 
         115                120                125
Ile Gly Tyr Arg Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Thr 
     130                135                140
Leu Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe Phe Tyr Gly Glu 
 145                150                155                160
Thr Val Ala Asp Tyr Phe Ala Thr Phe Val Gln Arg Glu Glu Gln Leu 
                 165                170                175
Gln Phe Leu Ile Arg Tyr His Arg Phe Ile Ser Phe Ala Leu Tyr Leu 
             180                185                190
Ala Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg 
         195                200                205
Leu Gln Phe Tyr Met Phe Ala Trp Thr His Val Thr Leu Leu Ile Thr 
     210                215                220
Val Thr Gln Ser His Leu Val Ile Gln Asn Leu Phe Glu Gly Met Ile 
 225                230                235                240
Trp Phe Leu Val Pro Ile Ser Ser Val Ile Cys Asn Asp Ile Thr Ala 
                 245                250                255
Tyr Leu Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu Ile Lys Leu Ser 
             260                265                270
Pro Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe Phe Ser Thr Val 
         275                280                285
Val Phe Gly Phe Ile Ala Ala Tyr Val Leu Ser Lys Tyr Gln Tyr Phe 
     290                295                300
Val Cys Pro Val Glu Tyr Arg Ser Asp Val Asn Ser Phe Val Thr Glu 
 305                310                315                320
Cys Glu Pro Ser Glu Leu Phe Gln Leu Gln Thr Tyr Ser Leu Pro Pro 
                 325                330                335
Phe Leu Lys Ala Val Leu Arg Gln Glu Arg Val Ser Leu Tyr Pro Phe 
             340                345                350
Gln Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser Leu Ile Gly Pro 
         355                360                365
Phe Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys 
     370                375                380
Asp Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe 
 385                390                395                400
Asp Cys Gln Tyr Leu Met Ala Thr Phe Val His Val Tyr Ile Thr Ser 
                 405                410                415
Phe Ile Arg Gly Pro Asn Pro Ser Lys Val Leu Gln Gln Leu Leu Val 
             420                425                430
Leu Gln Pro Glu Gln Gln Leu Asn Ile Tyr Lys Thr Leu Lys Thr His 
         435                440                445
Leu Ile Glu Lys Gly Ile Leu Gln Pro Thr Leu Lys Val 
     450                455                460



<210> 175
<211> 3732
<212> DNA
<213> Rattus norvegicus
<308> AB009999
<400> 175

tgacatgct  gagctgcgg  accgcgggg  ctgccccgg  cccggggga  cggggacgc  60
gccaccccg  gagggagag  cggccggcg  cgaccacga  accgagagc  ccagcgaca  120
agaaacaga  attgatgac  ggtatggag  tctcgatgc  agaggagat  ccgatgttc  180
tgaggtccc  ccatcctca  acaggaccc  cgagattct  aagaaagcc  tgtctggac  240
gtcatcaag  tggaagaac  ggtggattc  tgggatcct  accctgacc  tgatctccc  300
cttcttcct  atcatctat  tggggtcct  catgctgat  cttctggtt  tgggcatcc  360
ggtgaagtg  ttccaggag  tcataacca  cgggtacag  gtctaccac  cctacgacc  420
cccgtggtt  agaacacta  gttggtact  cctcctatg  gtgaactac  tcttctatg  480
agagacagt  gcagattac  tcgccacgt  cgttcagaa  gaggagcag  tgcagttcc  540
cattcgcta  cacaggttc  tatccttcg  cctctacct  gcaggtttc  gcatgttcg  600
cctgagctt  gtgaagaaa  actaccgac  acagttcta  atgttcgca  ggactcacg  660
cactttact  ataaccgtc  ctcagtcac  tcttgtcat  caaaatctg  ttgaaggca  720
gatatggtt  cttgtcccc  tatcaagcg  catctgcaa  gatatcacg  cttaccttt  780
tggattttt  tttggaaga  ctcctttaa  taagctgtc  cctaagaag  cctgggaag  840
attcattgg  ggtttcttc  ccacagtca  atttggatt  attgctgcc  atgtgttgt  900
caagtatca  tactttgtg  gcccggtgg  gtaccgaag  gacgtcaac  ccttcgtga  960
agaatgtga  ccctcagaa  tgttccagc  tcagaatta  tccctccct  cgttcctac  1020
ggcagtgct  agccgggag  ccgtgagct  gtacccctt  cagatacac  gcattgccc  1080
ttcaacatt  gcatcactg  tcggcccat  cggaggctt  ttcgccagt  gattcaaaa  1140
agctttcaa  atcaaggac  ttgcaaaca  tattcctgg  catggaggg  taatggaca  1200
gttcgattg  cagtatttg  tggcgacgt  cgtgcacgt  tacatcacc  gcttcatca  1260
gggtccgaa  cccagcaaa  tgctccagc  gctcctagt  cttcagcca  agcagcagt  1320
aaacatcta  agaaccctg  agatacatc  cacggagaa  ggcatcctg  agcccacct  1380
gaaggtgta  ctgtcctga  gggacagac  gctgaggag  aaggagctc  cagagcagc  1440
ccgactgaa  tcttgcact  agccagcct  gggctagaa  ctcagtaga  gcaggtttt  1500
cagatacga  tgtttctct  tctctgaaa  tactgtgaa  atttaacaa  cacgagatc  1560
gagacgagt  cgcatcagt  gccgccgtg  aagatccgt  cttttctaa  atgtatttt  1620
caatgttaa  ttctccgcc  ttactggcc  ggctccatg  tgtaggagg  ttaaagagt  1680
aagcactgt  acctgaggc  gaggccccc  taggctcgt  cctggcagt  tgatccttc  1740
cacaaacac  gacctttgc  ctgactggg  gctgcctct  tgtggctgg  gatgctcag  1800
aggcaccct  ggaagcgag  cctagggct  cctcctcta  tgacctcag  catttctgc  1860
ggctgagtt  gattaaaaa  gaaagaaaa  gagcgcttg  ccacttctc  ctcttcttt  1920
tgtttgttt  tacacacca  gcaggcgcc  cactcctag  ctctgttcc  gctggaccg  1980
ctgcctact  tcagagaaa  agccatctg  ccagtggaa  caccctggt  ttaagtagt  2040
tcaaaccaa  aggtagagg  tgaaactta  cccactatt  atttgttta  aaagaaggc  2100
tcagaatcc  tctctgatg  aacttttgg  gaagcacgt  accaacttc  caagagact  2160
aggagtggg  cctgctcct  caccaaaac  cctcaccca  gacggtggt  ctgtgagca  2220
gggtggagg  tgagtcggc  ggctgcctg  ggtgagctg  gcactgcat  gcggtgcca  2280
gcctgcctc  atctctgtg  acagcacac  tggagacga  ggttttccc  gaagaccca  2340
ctcagagcc  gccccctga  ggcaattaa  ctctgtcac  ttgcacttc  tgtcatgcc  2400
tgaaaacca  gagtaaaga  caagcagaa  taatagcca  gaagcagaa  agcacagga  2460
agccacgcc  tcttctgta  gtgggcagg  cactgtaaa  actctagcc  atcacagca  2520
cgttgttaa  taagctgcc  ccaagtgtg  tctgcagcc  tattgaacc  aatgtcagg  2580
tcacccgca  agatgacct  gttccccaa  ctcagcacc  agaggtgga  aaatggaga  2640
accataaag  ataatttgg  catgaaaga  taaatattt  tgtttaaat  agaaatgga  2700
tccagtcac  acatttcct  cccagtgtg  atgaaccca  agccatcct  ggctctgta  2760
gcacatggc  tatgtgtga  catggcaga  gctgtggtc  tcagtccca  aatgccact  2820
ttggcccct  ggtgacttg  gaccctggg  tccattcag  ctgtgtcct  tgcacgcag  2880
cagccgagg  agcattggc  acattacag  gactccctc  cagtcagga  accggggag  2940
tgatgtcag  ttccctgct  ttgtttgtc  ctcgccctg  cccagaagt  gaccatgac  3000
cagttgcag  caccgagga  gctgagaga  gccttgtga  aggatcatt  cccgagaac  3060
gggcagttt  caaaggtgt  aaggatgcc  ggggacagg  tggattctc  ttacccacc  3120
tgctgtcca  gcgtcgtga  gggttgcga  gcagaatta  gagagcatt  cttaataca  3180
gtattaaaa  tcaatattc  tctaaacaa  ggatgaaag  aggttacgg  aaaagcttt  3240
cttaaatag  ttttcttag  gctgggtgt  cattacgcc  tattaaaac  agggcgttc  3300
ctgacaacg  cctagagat  aacatttta  cgtactttc  cagcgtgta  attaaagtg  3360
actatactt  agcaagcaa  catcctaag  gccatgtga  gagcgctac  tttgcactg  3420
aagaagctt  atccagcgg  gtgacgcag  ggacaaatg  caggccctc  aggcgggga  3480
ccttcagtg  aaaactgcc  cttgaactg  tgctgactt  ttagcccgt  ggatgatga  3540
gtccgagaa  ggggcgttc  ccccagcct  ccttgtggg  ttgcacaga  agttgctgt  3600
atggcgaca  ctggtttga  gaaaggtcg  ggcgctgtg  atatactgt  cagggtgag  3660
gtttatgat  cgtgtcaat  agttctcta  atctttata  tgaaactgg  atagaaaaa  3720
aaaaatcca  ca  3732



<210> 176
<211> 461
<212> PRT
<213> Rattus norvegicus
<308> O35052
<400> 176

Met Leu Glu Leu Arg His Arg Gly Gly Cys Pro Gly Pro Gly Gly Ala 
  1               5                  10                  15
Gly Thr Pro Pro Pro Arg Glu Gly Glu Ala Ala Gly Gly Asp His Glu 
             20                  25                  30
Thr Glu Ser Thr Ser Asp Lys Glu Thr Asp Ile Asp Asp Arg Tyr Gly 
         35                  40                  45
Asp Leu Asp Ala Arg Gly Asp Ser Asp Val Pro Glu Val Pro Pro Ser 
     50                  55                  60
Ser Asp Arg Thr Pro Glu Ile Leu Lys Lys Ala Leu Ser Gly Leu Ser 
 65                  70                  75                  80
Ser Arg Trp Lys Asn Trp Trp Ile Arg Gly Ile Leu Thr Leu Thr Met 
                 85                  90                  95
Ile Ser Leu Phe Phe Leu Ile Ile Tyr Met Gly Ser Phe Met Leu Met 
             100                105                110
Leu Leu Val Leu Gly Ile Gln Val Lys Cys Phe Gln Glu Ile Ile Thr 
         115                120                125
Ile Gly Tyr Arg Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Thr 
     130                135                140
Leu Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe Phe Tyr Gly Glu 
 145                150                155                160
Thr Val Ala Asp Tyr Phe Ala Thr Phe Val Gln Arg Glu Glu Gln Leu 
                 165                170                175
Gln Phe Leu Ile Arg Tyr His Arg Phe Ile Ser Phe Ala Leu Tyr Leu 
             180                185                190
Ala Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg 
         195                200                205
Leu Gln Phe Tyr Met Phe Ala Trp Thr His Val Thr Leu Leu Ile Thr 
     210                215                220
Val Thr Gln Ser His Leu Val Ile Gln Asn Leu Phe Glu Gly Met Ile 
 225                230                235                240
Trp Phe Leu Val Pro Ile Ser Ser Val Ile Cys Asn Asp Ile Thr Ala 
                 245                250                255
Tyr Leu Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu Ile Lys Leu Ser 
             260                265                270
Pro Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe Phe Ser Thr Val 
         275                280                285
Ile Phe Gly Phe Ile Ala Ala Tyr Val Leu Ser Lys Tyr Gln Tyr Phe 
     290                295                300
Val Cys Pro Val Glu Tyr Arg Ser Asp Val Asn Ser Phe Val Thr Glu 
 305                310                315                320
Cys Glu Pro Ser Glu Leu Phe Gln Leu Gln Asn Tyr Ser Leu Pro Pro 
                 325                330                335
Phe Leu Gln Ala Val Leu Ser Arg Glu Thr Val Ser Leu Tyr Pro Phe 
             340                345                350
Gln Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser Leu Ile Gly Pro 
         355                360                365
Phe Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys 
     370                375                380
Asp Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe 
 385                390                395                400
Asp Cys Gln Tyr Leu Met Ala Thr Phe Val His Val Tyr Ile Thr Ser 
                 405                410                415
Phe Ile Arg Gly Pro Asn Pro Ser Lys Val Leu Gln Gln Leu Leu Val 
             420                425                430
Leu Gln Pro Glu Gln Gln Leu Asn Ile Tyr Arg Thr Leu Lys Ile His 
         435                440                445
Leu Thr Glu Lys Gly Ile Leu Gln Pro Thr Trp Lys Val 
     450                455                460



<210> 177
<211> 2356
<212> DNA
<213> Homo sapiens
<308> U65887
<400> 177

gaattcggc  cgagcgggg  gggaggggc  tgcgcggcg  cgggagccc  gagccgcgc  60
aaagcgggt  aagcgtcct  cttttctcc  cgccccttc  cctcctcct  cctgggcct  120
tgcgtggag  cgcgcacct  gcaaccgga  gccgcgtct  cgccttctc  gctcgcgcc  180
ggcgcccgg  gcctgcccg  gacctccgc  ggagccgcg  tcgctgcag  cggcctcga  240
cgctctctc  ttgatgccg  tttggaggt  accggcgcg  cggccgctc  atggtgggg  300
cgcgttagt  gctgcggct  cgcgggact  cagggcgcg  ctgcgaggt  gcggggcgc  360
ccgcctgca  aaccctgct  gcagctcag  tttcggggt  cttgaggag  ccgccacgg  420
agcgcggga  cggaagatg  tggagctga  gcaccgggg  agctgcccc  gccccaggg  480
agcggtgtc  ccgccacac  gcgagggag  ggcggccgg  ggcgaccac  aaaccgaga  540
caccagcga  aaagaaaca  atattgatg  cagatatgg  gatttggat  ccagaacag  600
ttctgatat  ccggaaatt  caccatcct  agatagaac  cctgagatt  tcaaaaaag  660
tctatctgg  ttatcttca  ggtggaaaa  ctggtggat  cgtggaatt  tcactctaa  720
tatgatctc  ttgtttttc  tgatcatct  tatgggatc  ttcatgctg  tgcttcttg  780
tctgggcat  caagtgaaa  gcttccatg  aattatcac  ataggttat  gagtctatc  840
ttcttatga  ctaccatgg  ttagaacac  aagttggta  tttctattg  gtgtaaact  900
ctttttcta  ggagagact  tagctgatt  ttttgctac  tttgttcaa  gagaagaac  960
acttcagtt  ctcattcgc  accatagat  tatatcatt  gccctctat  tggcaggtt  1020
ctgcatgtt  gtactgagt  tggtgaaga  acattatcg  ctgcagttt  atatgttcg  1080
atggactca  gtcacttta  tgataactg  cactcagtc  caccttgtc  tccaaaatc  1140
gtttgaagg  atgatatgg  tccttgttc  aatatcaag  gttatctgc  atgacataa  1200
tgcttacct  tttggattt  tttttggga  aactccatt  attaagttg  ctcctaaaa  1260
gacttggga  ggattcatt  gtggtttct  ttccacagt  gtgtttgga  tcattgctg  1320
ctatgtgtt  tccaaatac  agtactttg  ctgcccagt  gaataccga  gtgatgtaa  1380
ctccttcgt  acagaatgt  agccctcag  acttttcca  cttcagact  actcacttc  1440
accctttct  aaggcagtc  tgagacagg  aagagtgag  ttgtaccct  tccagatcc  1500
cagcattgc  ctgtcaacc  ttgcatctt  aattggccc  tttggaggc  tctttgcta  1560
tggattcaa  agagccttc  aaatcaagg  ttttgcaaa  accattcct  gacatggtg  1620
gataatgga  agatttgat  gtcagtatt  gatggcaac  tttgtacat  tgtacatca  1680
aagttttat  cggggccca  atcccagca  agtgctaca  cagttgttg  tgcttcaac  1740
tgaacagca  ttaaatata  ataaaccct  aagactcat  tcattgaga  aggatccta  1800
aacccacct  gaaggtata  ctggatcca  agagggaag  actgacaag  aggaattat  1860
cagaaaaac  ctgacagat  ttttataaa  tgtacagaa  aatagttaa  aatgcaata  1920
gttgaagtt  tccagatat  tttctctct  aaattactg  gaatattta  caaacactt  1980
cttgatcta  gttatgaaa  aagtagcaa  ttgccagca  aatgtcttg  accttttct  2040
aagtgtatt  tctgatgtg  acttccttc  ccttacttg  taggtttca  taatttaaa  2100
gagtcaaac  ctataaatg  gtaagttga  gatgtttta  gattgcacc  ggcagtgtg  2160
ctttttgca  caaatattt  cctggcagt  tgccttttt  caacaaata  ttactttgc  2220
cttggagct  cttttaatt  tagcaaaat  ttttatgca  ggcacaata  gaagtcagt  2280
ctcctgcac  tcctcctca  gtagtctgg  gtactttct  aagggctta  ttggattta  2340
aaaaaaaaa  aaaaaa  2356



<210> 178
<211> 461
<212> PRT
<213> Homo sapiens
<308> Q92903
<400> 178

Met Leu Glu Leu Arg His Arg Gly Ser Cys Pro Gly Pro Arg Glu Ala 
  1               5                  10                  15
Val Ser Pro Pro His Arg Glu Gly Glu Ala Ala Gly Gly Asp His Glu 
             20                  25                  30
Thr Glu Ser Thr Ser Asp Lys Glu Thr Asp Ile Asp Asp Arg Tyr Gly 
         35                  40                  45
Asp Leu Asp Ser Arg Thr Asp Ser Asp Ile Pro Glu Ile Pro Pro Ser 
     50                  55                  60
Ser Asp Arg Thr Pro Glu Ile Leu Lys Lys Ala Leu Ser Gly Leu Ser 
 65                  70                  75                  80
Ser Arg Trp Lys Asn Trp Trp Ile Arg Gly Ile Leu Thr Leu Thr Met 
                 85                  90                  95
Ile Ser Leu Phe Phe Leu Ile Ile Tyr Met Gly Ser Phe Met Leu Met 
             100                105                110
Leu Leu Val Leu Gly Ile Gln Val Lys Cys Phe His Glu Ile Ile Thr 
         115                120                125
Ile Gly Tyr Arg Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Thr 
     130                135                140
Leu Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe Phe Tyr Gly Glu 
 145                150                155                160
Thr Val Ala Asp Tyr Phe Ala Thr Phe Val Gln Arg Glu Glu Gln Leu 
                 165                170                175
Gln Phe Leu Ile Arg Tyr His Arg Phe Ile Ser Phe Ala Leu Tyr Leu 
             180                185                190
Ala Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg 
         195                200                205
Leu Gln Phe Tyr Met Phe Ala Trp Thr His Val Thr Leu Leu Ile Thr 
     210                215                220
Val Thr Gln Ser His Leu Val Ile Gln Asn Leu Phe Glu Gly Met Ile 
 225                230                235                240
Trp Phe Leu Val Pro Ile Ser Ser Val Ile Cys Asn Asp Ile Thr Ala 
                 245                250                255
Tyr Leu Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu Ile Lys Leu Ser 
             260                265                270
Pro Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe Phe Ser Thr Val 
         275                280                285
Val Phe Gly Phe Ile Ala Ala Tyr Val Leu Ser Lys Tyr Gln Tyr Phe 
     290                295                300
Val Cys Pro Val Glu Tyr Arg Ser Asp Val Asn Ser Phe Val Thr Glu 
 305                310                315                320
Cys Glu Pro Ser Glu Leu Phe Gln Leu Gln Thr Tyr Ser Leu Pro Pro 
                 325                330                335
Phe Leu Lys Ala Val Leu Arg Gln Glu Arg Val Ser Leu Tyr Pro Phe 
             340                345                350
Gln Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser Leu Ile Gly Pro 
         355                360                365
Phe Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys 
     370                375                380
Asp Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe 
 385                390                395                400
Asp Cys Gln Tyr Leu Met Ala Thr Phe Val His Val Tyr Ile Thr Ser 
                 405                410                415
Phe Ile Arg Gly Pro Asn Pro Ser Lys Val Leu Gln Gln Leu Leu Val 
             420                425                430
Leu Gln Pro Glu Gln Gln Leu Asn Ile Tyr Lys Thr Leu Lys Thr His 
         435                440                445
Leu Ile Glu Lys Gly Ile Leu Gln Pro Thr Leu Lys Val 
     450                455                460



<210> 179
<211> 3732
<212> DNA
<213> Rattus norvegicus
<308> AB009999
<400> 179

tgacatgct  gagctgcgg  accgcgggg  ctgccccgg  cccggggga  cggggacgc  60
gccaccccg  gagggagag  cggccggcg  cgaccacga  accgagagc  ccagcgaca  120
agaaacaga  attgatgac  ggtatggag  tctcgatgc  agaggagat  ccgatgttc  180
tgaggtccc  ccatcctca  acaggaccc  cgagattct  aagaaagcc  tgtctggac  240
gtcatcaag  tggaagaac  ggtggattc  tgggatcct  accctgacc  tgatctccc  300
cttcttcct  atcatctat  tggggtcct  catgctgat  cttctggtt  tgggcatcc  360
ggtgaagtg  ttccaggag  tcataacca  cgggtacag  gtctaccac  cctacgacc  420
cccgtggtt  agaacacta  gttggtact  cctcctatg  gtgaactac  tcttctatg  480
agagacagt  gcagattac  tcgccacgt  cgttcagaa  gaggagcag  tgcagttcc  540
cattcgcta  cacaggttc  tatccttcg  cctctacct  gcaggtttc  gcatgttcg  600
cctgagctt  gtgaagaaa  actaccgac  acagttcta  atgttcgca  ggactcacg  660
cactttact  ataaccgtc  ctcagtcac  tcttgtcat  caaaatctg  ttgaaggca  720
gatatggtt  cttgtcccc  tatcaagcg  catctgcaa  gatatcacg  cttaccttt  780
tggattttt  tttggaaga  ctcctttaa  taagctgtc  cctaagaag  cctgggaag  840
attcattgg  ggtttcttc  ccacagtca  atttggatt  attgctgcc  atgtgttgt  900
caagtatca  tactttgtg  gcccggtgg  gtaccgaag  gacgtcaac  ccttcgtga  960
agaatgtga  ccctcagaa  tgttccagc  tcagaatta  tccctccct  cgttcctac  1020
ggcagtgct  agccgggag  ccgtgagct  gtacccctt  cagatacac  gcattgccc  1080
ttcaacatt  gcatcactg  tcggcccat  cggaggctt  ttcgccagt  gattcaaaa  1140
agctttcaa  atcaaggac  ttgcaaaca  tattcctgg  catggaggg  taatggaca  1200
gttcgattg  cagtatttg  tggcgacgt  cgtgcacgt  tacatcacc  gcttcatca  1260
gggtccgaa  cccagcaaa  tgctccagc  gctcctagt  cttcagcca  agcagcagt  1320
aaacatcta  agaaccctg  agatacatc  cacggagaa  ggcatcctg  agcccacct  1380
gaaggtgta  ctgtcctga  gggacagac  gctgaggag  aaggagctc  cagagcagc  1440
ccgactgaa  tcttgcact  agccagcct  gggctagaa  ctcagtaga  gcaggtttt  1500
cagatacga  tgtttctct  tctctgaaa  tactgtgaa  atttaacaa  cacgagatc  1560
gagacgagt  cgcatcagt  gccgccgtg  aagatccgt  cttttctaa  atgtatttt  1620
caatgttaa  ttctccgcc  ttactggcc  ggctccatg  tgtaggagg  ttaaagagt  1680
aagcactgt  acctgaggc  gaggccccc  taggctcgt  cctggcagt  tgatccttc  1740
cacaaacac  gacctttgc  ctgactggg  gctgcctct  tgtggctgg  gatgctcag  1800
aggcaccct  ggaagcgag  cctagggct  cctcctcta  tgacctcag  catttctgc  1860
ggctgagtt  gattaaaaa  gaaagaaaa  gagcgcttg  ccacttctc  ctcttcttt  1920
tgtttgttt  tacacacca  gcaggcgcc  cactcctag  ctctgttcc  gctggaccg  1980
ctgcctact  tcagagaaa  agccatctg  ccagtggaa  caccctggt  ttaagtagt  2040
tcaaaccaa  aggtagagg  tgaaactta  cccactatt  atttgttta  aaagaaggc  2100
tcagaatcc  tctctgatg  aacttttgg  gaagcacgt  accaacttc  caagagact  2160
aggagtggg  cctgctcct  caccaaaac  cctcaccca  gacggtggt  ctgtgagca  2220
gggtggagg  tgagtcggc  ggctgcctg  ggtgagctg  gcactgcat  gcggtgcca  2280
gcctgcctc  atctctgtg  acagcacac  tggagacga  ggttttccc  gaagaccca  2340
ctcagagcc  gccccctga  ggcaattaa  ctctgtcac  ttgcacttc  tgtcatgcc  2400
tgaaaacca  gagtaaaga  caagcagaa  taatagcca  gaagcagaa  agcacagga  2460
agccacgcc  tcttctgta  gtgggcagg  cactgtaaa  actctagcc  atcacagca  2520
cgttgttaa  taagctgcc  ccaagtgtg  tctgcagcc  tattgaacc  aatgtcagg  2580
tcacccgca  agatgacct  gttccccaa  ctcagcacc  agaggtgga  aaatggaga  2640
accataaag  ataatttgg  catgaaaga  taaatattt  tgtttaaat  agaaatgga  2700
tccagtcac  acatttcct  cccagtgtg  atgaaccca  agccatcct  ggctctgta  2760
gcacatggc  tatgtgtga  catggcaga  gctgtggtc  tcagtccca  aatgccact  2820
ttggcccct  ggtgacttg  gaccctggg  tccattcag  ctgtgtcct  tgcacgcag  2880
cagccgagg  agcattggc  acattacag  gactccctc  cagtcagga  accggggag  2940
tgatgtcag  ttccctgct  ttgtttgtc  ctcgccctg  cccagaagt  gaccatgac  3000
cagttgcag  caccgagga  gctgagaga  gccttgtga  aggatcatt  cccgagaac  3060
gggcagttt  caaaggtgt  aaggatgcc  ggggacagg  tggattctc  ttacccacc  3120
tgctgtcca  gcgtcgtga  gggttgcga  gcagaatta  gagagcatt  cttaataca  3180
gtattaaaa  tcaatattc  tctaaacaa  ggatgaaag  aggttacgg  aaaagcttt  3240
cttaaatag  ttttcttag  gctgggtgt  cattacgcc  tattaaaac  agggcgttc  3300
ctgacaacg  cctagagat  aacatttta  cgtactttc  cagcgtgta  attaaagtg  3360
actatactt  agcaagcaa  catcctaag  gccatgtga  gagcgctac  tttgcactg  3420
aagaagctt  atccagcgg  gtgacgcag  ggacaaatg  caggccctc  aggcgggga  3480
ccttcagtg  aaaactgcc  cttgaactg  tgctgactt  ttagcccgt  ggatgatga  3540
gtccgagaa  ggggcgttc  ccccagcct  ccttgtggg  ttgcacaga  agttgctgt  3600
atggcgaca  ctggtttga  gaaaggtcg  ggcgctgtg  atatactgt  cagggtgag  3660
gtttatgat  cgtgtcaat  agttctcta  atctttata  tgaaactgg  atagaaaaa  3720
aaaaatcca  ca  3732



<210> 180
<211> 461
<212> PRT
<213> Rattus norvegicus
<308> O35052
<400> 180

Met Leu Glu Leu Arg His Arg Gly Gly Cys Pro Gly Pro Gly Gly Ala 
  1               5                  10                  15
Gly Thr Pro Pro Pro Arg Glu Gly Glu Ala Ala Gly Gly Asp His Glu 
             20                  25                  30
Thr Glu Ser Thr Ser Asp Lys Glu Thr Asp Ile Asp Asp Arg Tyr Gly 
         35                  40                  45
Asp Leu Asp Ala Arg Gly Asp Ser Asp Val Pro Glu Val Pro Pro Ser 
     50                  55                  60
Ser Asp Arg Thr Pro Glu Ile Leu Lys Lys Ala Leu Ser Gly Leu Ser 
 65                  70                  75                  80
Ser Arg Trp Lys Asn Trp Trp Ile Arg Gly Ile Leu Thr Leu Thr Met 
                 85                  90                  95
Ile Ser Leu Phe Phe Leu Ile Ile Tyr Met Gly Ser Phe Met Leu Met 
             100                105                110
Leu Leu Val Leu Gly Ile Gln Val Lys Cys Phe Gln Glu Ile Ile Thr 
         115                120                125
Ile Gly Tyr Arg Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Thr 
     130                135                140
Leu Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe Phe Tyr Gly Glu 
 145                150                155                160
Thr Val Ala Asp Tyr Phe Ala Thr Phe Val Gln Arg Glu Glu Gln Leu 
                 165                170                175
Gln Phe Leu Ile Arg Tyr His Arg Phe Ile Ser Phe Ala Leu Tyr Leu 
             180                185                190
Ala Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg 
         195                200                205
Leu Gln Phe Tyr Met Phe Ala Trp Thr His Val Thr Leu Leu Ile Thr 
     210                215                220
Val Thr Gln Ser His Leu Val Ile Gln Asn Leu Phe Glu Gly Met Ile 
 225                230                235                240
Trp Phe Leu Val Pro Ile Ser Ser Val Ile Cys Asn Asp Ile Thr Ala 
                 245                250                255
Tyr Leu Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu Ile Lys Leu Ser 
             260                265                270
Pro Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe Phe Ser Thr Val 
         275                280                285
Ile Phe Gly Phe Ile Ala Ala Tyr Val Leu Ser Lys Tyr Gln Tyr Phe 
     290                295                300
Val Cys Pro Val Glu Tyr Arg Ser Asp Val Asn Ser Phe Val Thr Glu 
 305                310                315                320
Cys Glu Pro Ser Glu Leu Phe Gln Leu Gln Asn Tyr Ser Leu Pro Pro 
                 325                330                335
Phe Leu Gln Ala Val Leu Ser Arg Glu Thr Val Ser Leu Tyr Pro Phe 
             340                345                350
Gln Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser Leu Ile Gly Pro 
         355                360                365
Phe Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys 
     370                375                380
Asp Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe 
 385                390                395                400
Asp Cys Gln Tyr Leu Met Ala Thr Phe Val His Val Tyr Ile Thr Ser 
                 405                410                415
Phe Ile Arg Gly Pro Asn Pro Ser Lys Val Leu Gln Gln Leu Leu Val 
             420                425                430
Leu Gln Pro Glu Gln Gln Leu Asn Ile Tyr Arg Thr Leu Lys Ile His 
         435                440                445
Leu Thr Glu Lys Gly Ile Leu Gln Pro Thr Trp Lys Val 
     450                455                460



<210> 181
<211> 2356
<212> DNA
<213> Homo sapiens
<308> U65887
<400> 181

gaattcggc  cgagcgggg  gggaggggc  tgcgcggcg  cgggagccc  gagccgcgc  60
aaagcgggt  aagcgtcct  cttttctcc  cgccccttc  cctcctcct  cctgggcct  120
tgcgtggag  cgcgcacct  gcaaccgga  gccgcgtct  cgccttctc  gctcgcgcc  180
ggcgcccgg  gcctgcccg  gacctccgc  ggagccgcg  tcgctgcag  cggcctcga  240
cgctctctc  ttgatgccg  tttggaggt  accggcgcg  cggccgctc  atggtgggg  300
cgcgttagt  gctgcggct  cgcgggact  cagggcgcg  ctgcgaggt  gcggggcgc  360
ccgcctgca  aaccctgct  gcagctcag  tttcggggt  cttgaggag  ccgccacgg  420
agcgcggga  cggaagatg  tggagctga  gcaccgggg  agctgcccc  gccccaggg  480
agcggtgtc  ccgccacac  gcgagggag  ggcggccgg  ggcgaccac  aaaccgaga  540
caccagcga  aaagaaaca  atattgatg  cagatatgg  gatttggat  ccagaacag  600
ttctgatat  ccggaaatt  caccatcct  agatagaac  cctgagatt  tcaaaaaag  660
tctatctgg  ttatcttca  ggtggaaaa  ctggtggat  cgtggaatt  tcactctaa  720
tatgatctc  ttgtttttc  tgatcatct  tatgggatc  ttcatgctg  tgcttcttg  780
tctgggcat  caagtgaaa  gcttccatg  aattatcac  ataggttat  gagtctatc  840
ttcttatga  ctaccatgg  ttagaacac  aagttggta  tttctattg  gtgtaaact  900
ctttttcta  ggagagact  tagctgatt  ttttgctac  tttgttcaa  gagaagaac  960
acttcagtt  ctcattcgc  accatagat  tatatcatt  gccctctat  tggcaggtt  1020
ctgcatgtt  gtactgagt  tggtgaaga  acattatcg  ctgcagttt  atatgttcg  1080
atggactca  gtcacttta  tgataactg  cactcagtc  caccttgtc  tccaaaatc  1140
gtttgaagg  atgatatgg  tccttgttc  aatatcaag  gttatctgc  atgacataa  1200
tgcttacct  tttggattt  tttttggga  aactccatt  attaagttg  ctcctaaaa  1260
gacttggga  ggattcatt  gtggtttct  ttccacagt  gtgtttgga  tcattgctg  1320
ctatgtgtt  tccaaatac  agtactttg  ctgcccagt  gaataccga  gtgatgtaa  1380
ctccttcgt  acagaatgt  agccctcag  acttttcca  cttcagact  actcacttc  1440
accctttct  aaggcagtc  tgagacagg  aagagtgag  ttgtaccct  tccagatcc  1500
cagcattgc  ctgtcaacc  ttgcatctt  aattggccc  tttggaggc  tctttgcta  1560
tggattcaa  agagccttc  aaatcaagg  ttttgcaaa  accattcct  gacatggtg  1620
gataatgga  agatttgat  gtcagtatt  gatggcaac  tttgtacat  tgtacatca  1680
aagttttat  cggggccca  atcccagca  agtgctaca  cagttgttg  tgcttcaac  1740
tgaacagca  ttaaatata  ataaaccct  aagactcat  tcattgaga  aggatccta  1800
aacccacct  gaaggtata  ctggatcca  agagggaag  actgacaag  aggaattat  1860
cagaaaaac  ctgacagat  ttttataaa  tgtacagaa  aatagttaa  aatgcaata  1920
gttgaagtt  tccagatat  tttctctct  aaattactg  gaatattta  caaacactt  1980
cttgatcta  gttatgaaa  aagtagcaa  ttgccagca  aatgtcttg  accttttct  2040
aagtgtatt  tctgatgtg  acttccttc  ccttacttg  taggtttca  taatttaaa  2100
gagtcaaac  ctataaatg  gtaagttga  gatgtttta  gattgcacc  ggcagtgtg  2160
ctttttgca  caaatattt  cctggcagt  tgccttttt  caacaaata  ttactttgc  2220
cttggagct  cttttaatt  tagcaaaat  ttttatgca  ggcacaata  gaagtcagt  2280
ctcctgcac  tcctcctca  gtagtctgg  gtactttct  aagggctta  ttggattta  2340
aaaaaaaaa  aaaaaa  2356



<210> 182
<211> 461
<212> PRT
<213> Homo sapiens
<308> Q92903
<400> 182

Met Leu Glu Leu Arg His Arg Gly Ser Cys Pro Gly Pro Arg Glu Ala 
  1               5                  10                  15
Val Ser Pro Pro His Arg Glu Gly Glu Ala Ala Gly Gly Asp His Glu 
             20                  25                  30
Thr Glu Ser Thr Ser Asp Lys Glu Thr Asp Ile Asp Asp Arg Tyr Gly 
         35                  40                  45
Asp Leu Asp Ser Arg Thr Asp Ser Asp Ile Pro Glu Ile Pro Pro Ser 
     50                  55                  60
Ser Asp Arg Thr Pro Glu Ile Leu Lys Lys Ala Leu Ser Gly Leu Ser 
 65                  70                  75                  80
Ser Arg Trp Lys Asn Trp Trp Ile Arg Gly Ile Leu Thr Leu Thr Met 
                 85                  90                  95
Ile Ser Leu Phe Phe Leu Ile Ile Tyr Met Gly Ser Phe Met Leu Met 
             100                105                110
Leu Leu Val Leu Gly Ile Gln Val Lys Cys Phe His Glu Ile Ile Thr 
         115                120                125
Ile Gly Tyr Arg Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Thr 
     130                135                140
Leu Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe Phe Tyr Gly Glu 
 145                150                155                160
Thr Val Ala Asp Tyr Phe Ala Thr Phe Val Gln Arg Glu Glu Gln Leu 
                 165                170                175
Gln Phe Leu Ile Arg Tyr His Arg Phe Ile Ser Phe Ala Leu Tyr Leu 
             180                185                190
Ala Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg 
         195                200                205
Leu Gln Phe Tyr Met Phe Ala Trp Thr His Val Thr Leu Leu Ile Thr 
     210                215                220
Val Thr Gln Ser His Leu Val Ile Gln Asn Leu Phe Glu Gly Met Ile 
 225                230                235                240
Trp Phe Leu Val Pro Ile Ser Ser Val Ile Cys Asn Asp Ile Thr Ala 
                 245                250                255
Tyr Leu Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu Ile Lys Leu Ser 
             260                265                270
Pro Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe Phe Ser Thr Val 
         275                280                285
Val Phe Gly Phe Ile Ala Ala Tyr Val Leu Ser Lys Tyr Gln Tyr Phe 
     290                295                300
Val Cys Pro Val Glu Tyr Arg Ser Asp Val Asn Ser Phe Val Thr Glu 
 305                310                315                320
Cys Glu Pro Ser Glu Leu Phe Gln Leu Gln Thr Tyr Ser Leu Pro Pro 
                 325                330                335
Phe Leu Lys Ala Val Leu Arg Gln Glu Arg Val Ser Leu Tyr Pro Phe 
             340                345                350
Gln Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser Leu Ile Gly Pro 
         355                360                365
Phe Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys 
     370                375                380
Asp Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe 
 385                390                395                400
Asp Cys Gln Tyr Leu Met Ala Thr Phe Val His Val Tyr Ile Thr Ser 
                 405                410                415
Phe Ile Arg Gly Pro Asn Pro Ser Lys Val Leu Gln Gln Leu Leu Val 
             420                425                430
Leu Gln Pro Glu Gln Gln Leu Asn Ile Tyr Lys Thr Leu Lys Thr His 
         435                440                445
Leu Ile Glu Lys Gly Ile Leu Gln Pro Thr Leu Lys Val 
     450                455                460



<210> 183
<211> 1529
<212> DNA
<213> Rattus norvegicus
<308> AB010154
<400> 183

ggacagcga  atcctcttg  taacgagaa  ccgcgggcg  cccaaagcc  cgggacccg  60
gcgaccaaa  cccttgcga  gcctttcgc  tccctgctc  tggtggtgg  ggtgccctg  120
gcccctctc  ggccgggca  acgaagacc  acacggcgc  caggccccc  gccgcggcg  180
ccccgcggc  ccagcccag  gagaagatg  gcgtgggct  ccctgagcc  gaaccgctc  240
actccctgc  ttgctgtgg  ccgggggcc  cccctgtac  tggtgcagg  gtgcccctc  300
tcacagaag  catgcaagc  ctgaccctg  gcacactgg  tgccagcga  gtcaccaag  360
actacgagc  cgtgcggga  ctgggtaaa  ggacctacg  gaaggtcga  ctggtggct  420
acaagggca  aggcactaa  atggccctg  aatttgtga  taagagtaa  accaagctg  480
agaacttcc  gcgtgaggt  agcatcacc  acagcctgt  gtctagccc  ttcatcatc  540
aggtcttcg  cgtggtctt  gagacggag  agtgctatg  ctttgctca  gagtatgca  600
ctgctgggg  cctgtttga  atcatccct  ctcaggtgg  gctcccgga  gacacggtg  660
agcgctgtg  gcagcagct  gggctggca  tggacttca  gcatagcag  cagctggtg  720
accgcgaca  caagcccga  aatgtgctg  tgtttgacc  tgagtgccg  cgcgtgaag  780
tggctgact  cggcatgac  cggcgcgta  gctgccgtg  gaagcgagt  agcggcact  840
taccctaca  ggcgcccga  gtgtgccag  ctggccgcg  cgatggctt  gcggtggac  900
cgggcgtgg  tgtgtgggc  ttcggcgtg  tcatcttct  cgtgctcac  ggcaacttc  960
cgtgggagg  tgcgtcagg  gccgatgcc  tcttcgagg  atttgtgcg  tggcagcgg  1020
gtcgcctgc  cgggctgcc  tcccagtgg  gacgcttta  ggagcctgc  ctacgcatg  1080
tccagcggc  tctggcgct  gagcctgag  ggcgtgggc  cgccaagga  gtctttcgc  1140
tcctcaagc  tgagctcac  tctgagctg  ggcggcggc  atcgcaccg  gcacgaaag  1200
cacctgggg  ccgcctgcc  gggcccctg  gccttgagg  tccagggcc  ctcaagcgc  1260
ctgtgctca  cgagagtgg  agcggctcg  ggccttccc  acccagcgt  gggcccgtg  1320
tacccgtgc  agtgccagt  ccagtaccc  tacctgagg  tggtctggc  ccacccgca  1380
ccccgggca  gaccgacgg  cgtgcggac  agagcaaag  gcaggtggt  ttggccaca  1440
ccatcgaga  ctgcgtctg  gccgctgca  cacagctgt  gcggggaag  cgcgcgctc  1500
aacccgtac  agggacaag  agcagccgc  1529



<210> 184
<211> 417
<212> PRT
<213> Rattus norvegicus
<308> BAA36362
<400> 184

Met Ser Val Gly Cys Pro Glu Pro Glu Pro Leu His Ser Leu Pro Cys 
  1               5                  10                  15
Cys Gly Pro Gly Ala Ala Pro Val Pro Gly Ala Gly Val Pro Leu Leu 
             20                  25                  30
Thr Glu Asp Met Gln Ala Leu Thr Leu Arg Thr Leu Ala Ala Ser Asp 
         35                  40                  45
Val Thr Lys His Tyr Glu Leu Val Arg Glu Leu Gly Lys Gly Thr Tyr 
     50                  55                  60
Gly Lys Val Asp Leu Val Ala Tyr Lys Gly Thr Gly Thr Lys Met Ala 
 65                  70                  75                  80
Leu Lys Phe Val Asn Lys Ser Lys Thr Lys Leu Lys Asn Phe Leu Arg 
                 85                  90                  95
Glu Val Ser Ile Thr Asn Ser Leu Ser Ser Ser Pro Phe Ile Ile Lys 
             100                105                110
Val Phe Asp Val Val Phe Glu Thr Glu Glu Cys Tyr Val Phe Ala Gln 
         115                120                125
Glu Tyr Ala Pro Ala Gly Asp Leu Phe Asp Ile Ile Pro Pro Gln Val 
     130                135                140
Gly Leu Pro Glu Asp Thr Val Lys Arg Cys Val Gln Gln Leu Gly Leu 
 145                150                155                160
Ala Leu Asp Phe Met His Ser Arg Gln Leu Val His Arg Asp Ile Lys 
                 165                170                175
Pro Glu Asn Val Leu Leu Phe Asp Arg Glu Cys Arg Arg Val Lys Leu 
             180                185                190
Ala Asp Phe Gly Met Thr Arg Arg Val Gly Cys Arg Val Lys Arg Val 
         195                200                205
Ser Gly Thr Ile Pro Tyr Thr Ala Pro Glu Val Cys Gln Ala Gly Arg 
     210                215                220
Ala Asp Gly Phe Ala Val Asp Thr Gly Val Asp Val Trp Ala Phe Gly 
 225                230                235                240
Val Leu Ile Phe Cys Val Leu Thr Gly Asn Phe Pro Trp Glu Ala Ala 
                 245                250                255
Ser Gly Ala Asp Ala Phe Phe Glu Glu Phe Val Arg Trp Gln Arg Gly 
             260                265                270
Arg Leu Pro Gly Leu Pro Ser Gln Trp Arg Arg Phe Thr Glu Pro Ala 
         275                280                285
Leu Arg Met Phe Gln Arg Leu Leu Ala Leu Glu Pro Glu Arg Arg Gly 
     290                295                300
Pro Ala Lys Glu Val Phe Arg Phe Leu Lys His Glu Leu Thr Ser Glu 
 305                310                315                320
Leu Arg Arg Arg Pro Ser His Arg Ala Arg Lys Pro Pro Gly Asp Arg 
                 325                330                335
Leu Pro Gly Pro Leu Arg Leu Glu Ala Pro Gly Pro Leu Lys Arg Thr 
             340                345                350
Val Leu Thr Glu Ser Gly Ser Gly Ser Arg Pro Ser Pro Pro Ser Val 
         355                360                365
Gly Pro Val Val Pro Val Pro Val Pro Val Pro Val Pro Val Pro Glu 
     370                375                380
Ala Gly Leu Ala Pro Pro Ala Pro Pro Gly Arg Thr Asp Gly Arg Ala 
 385                390                395                400
Asp Lys Ser Lys Gly Gln Val Val Leu Ala Thr Ala Ile Glu Ile Cys 
                 405                410                415
Val 
             420



<210> 185
<211> 2271
<212> DNA
<213> Homo sapiens
<308> AF387637
<400> 185

gaattaaag  gcagtaaaa  gtccactag  accccattg  caacggtga  tgaacgaga  60
actgaaaac  acacgtcac  tggagatgg  cgtcaagaa  ttacctctc  taccagccg  120
tcaggagct  ggtgtagaa  ctctatagc  tcctgtgca  atgaacaac  tcacatcgg  180
aactacaga  tgttgaaaa  aatcggcaa  gggaatttt  caaaagtaa  attggcaag  240
catatcctt  caggcagag  ggttgcaat  aaaataatt  acaaaactc  gttgaatcc  300
acaagtcta  aaaagctct  cagagaagt  agaataatg  agattttaa  tcatcccaa  360
atagtgaag  tattcgaag  cattgaaac  gaaaaaaca  tctacctaa  catggaata  420
gcaagtgga  gtgaagtat  tgactattt  gttgcacat  gcaggatga  ggaaaaaga  480
gcaagatct  aatttagac  gattgtgtc  gcagttcaa  actgccatc  gaaacggat  540
gtacatcga  acctcaagg  tgaaaatct  ttgttagat  ccgatatga  cattaaaat  600
gcagatttc  gttttagca  tgaatttac  gttggcggt  aactcgaca  gttttgtgg  660
agtcctcca  acgcagcac  tgagctctt  cagggcaag  aatatgacg  gccagaagt  720
gatgtgtgg  gtctggggg  cattttata  acactagtc  gtggctcac  tccctttga  780
gggcaaaac  taaaggaac  gagagagag  gtattaaga  ggaaataca  aattccctt  840
tacatgtct  cagactgtg  aaaccttct  aaacgtttc  tggtgctaa  tccaattaa  900
cgcggcact  tagagcaaa  catgaagga  aggtggatc  atgcagggc  tgaagaaga  960
gaactcaaa  catttgttg  accagagct  gacatctca  accaaaaaa  aatagatat  1020
atggtggga  tgggatatt  acaagaaga  attcaagaa  ctcttagta  gatgaaata  1080
gatgaaatc  cagctacat  tttgttatt  gggagaaaa  cttcagagc  ggatgctag  1140
gattccagt  ctagcagca  tctttcact  gctaaggtt  ggccgagca  tgatctcaa  1200
aacagtact  gccagtctc  tcaccacaa  gtgcagaga  gtgtttctt  aagccaaaa  1260
caaagacgc  acagtgacc  tgctggacc  gctattcct  ctgttgtgg  gtatccgaa  1320
aggagtcag  ccagcactg  agatagtga  ctcaaagaa  atggaattt  ctcccggaa  1380
tcaagtggc  gtgctgttg  aggaaaggg  attgctcca  ccagtccca  gcttgggaa  1440
gcaagtaat  ctaataagg  ggatattcc  gaacgcaag  aaagctcca  tgtccctag  1500
agtaacaca  catctggtg  aatgacacg  cgaaatact  atgtttgca  tgagagaac  1560
acagctgat  gacactcag  gattcagaa  ggcaaagaa  acagcacta  tcctgatca  1620
agaactcca  ttgcttcaa  acacagtat  agtagtgca  ccaccccag  tcgaatccg  1680
ttcccaaga  gcactgcca  tcgtagcac  ttccacggc  agccccggg  acggcgaac  1740
gcaacatat  atggccctc  tgcctctcc  agcctgtcc  atgaagcca  accattgtc  1800
cagactcga  gccgaggct  cactaatct  tttagtaaa  taacttcaa  actcacaag  1860
aggcttcca  ctgaatatg  gaggaacgg  agatatgag  gctcaagtc  caatgtatc  1920
gctgagcaa  aagatgaaa  caaagaagc  aagcctcga  ccctacgct  cacctggag  1980
atgaaaacc  ctagttcaa  ggatcccgg  gacatgatg  gggaaatcc  caaagtgtt  2040
gacgccaat  actgcgact  tgagcagag  gagcgcttc  tgctcttct  cgtccacgg  2100
gatgggcac  cggagaacc  cgtgcagtg  gaaatggaa  tgtgcaagc  gccaagact  2160
tctctgaac  gggtccggt  taagcggat  tcggggaca  ccatagcct  caaaaatat  2220
gcttccaaa  ttgccaatg  gctaaagct  taacccagt  attatgatg  a  2271



<210> 186
<211> 713
<212> PRT
<213> Homo sapiens
<308> P27448
<400> 186

Met Ser Thr Arg Thr Pro Leu Pro Thr Val Asn Glu Arg Asp Thr Glu 
  1               5                  10                  15
Asn His Thr Ser His Gly Asp Gly Arg Gln Glu Val Thr Ser Arg Thr 
             20                  25                  30
Ser Arg Ser Gly Ala Arg Cys Arg Asn Ser Ile Ala Ser Cys Ala Asp 
         35                  40                  45
Glu Gln Pro His Ile Gly Asn Tyr Arg Leu Leu Lys Thr Ile Gly Lys 
     50                  55                  60
Gly Asn Phe Ala Lys Val Lys Leu Ala Arg His Ile Leu Thr Gly Arg 
 65                  70                  75                  80
Glu Val Ala Ile Lys Ile Ile Asp Lys Thr Gln Leu Asn Pro Thr Ser 
                 85                  90                  95
Leu Gln Lys Leu Phe Arg Glu Val Arg Ile Met Lys Ile Leu Asn His 
             100                105                110
Pro Asn Ile Val Lys Leu Phe Glu Val Ile Glu Thr Gln Lys Thr Leu 
         115                120                125
Tyr Leu Ile Met Glu Tyr Ala Ser Gly Gly Lys Val Phe Asp Tyr Leu 
     130                135                140
Val Ala His Gly Arg Met Lys Glu Lys Glu Ala Arg Ser Lys Phe Arg 
 145                150                155                160
Gln Ile Val Ser Ala Val Gln Tyr Cys His Gln Lys Arg Ile Val His 
                 165                170                175
Arg Asp Leu Lys Ala Glu Asn Leu Leu Leu Asp Ala Asp Met Asn Ile 
             180                185                190
Lys Ile Ala Asp Phe Gly Phe Ser Asn Glu Phe Thr Val Gly Gly Lys 
         195                200                205
Leu Asp Thr Phe Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Leu Phe 
     210                215                220
Gln Gly Lys Lys Tyr Asp Gly Pro Glu Val Asp Val Trp Ser Leu Gly 
 225                230                235                240
Val Ile Leu Tyr Thr Leu Val Ser Gly Ser Leu Pro Phe Asp Gly Gln 
                 245                250                255
Asn Leu Lys Glu Leu Arg Glu Arg Val Leu Arg Gly Lys Tyr Arg Ile 
             260                265                270
Pro Phe Tyr Met Ser Thr Asp Cys Glu Asn Leu Leu Lys Arg Phe Leu 
         275                280                285
Val Leu Asn Pro Ile Lys Arg Gly Thr Leu Glu Gln Ile Met Lys Asp 
     290                295                300
Arg Trp Ile Asn Ala Gly His Glu Glu Asp Glu Leu Lys Pro Phe Val 
 305                310                315                320
Glu Pro Glu Leu Asp Ile Ser Asp Gln Lys Arg Ile Asp Ile Met Val 
                 325                330                335
Gly Met Gly Tyr Ser Gln Glu Glu Ile Gln Glu Ser Leu Ser Lys Met 
             340                345                350
Lys Tyr Asp Glu Ile Thr Ala Thr Tyr Leu Leu Leu Gly Arg Lys Ser 
         355                360                365
Ser Glu Val Arg Pro Ser Ser Asp Leu Asn Asn Ser Thr Gly Gln Ser 
     370                375                380
Pro His His Lys Val Gln Arg Ser Val Ser Ser Ser Gln Lys Gln Arg 
 385                390                395                400
Arg Tyr Ser Asp His Ala Gly Pro Gly Ile Pro Ser Val Val Ala Tyr 
                 405                410                415
Pro Lys Arg Ser Gln Thr Ser Thr Ala Asp Ser Asp Leu Lys Glu Asp 
             420                425                430
Gly Ile Ser Ser Arg Lys Ser Thr Gly Ser Ala Val Gly Gly Lys Gly 
         435                440                445
Ile Ala Pro Ala Ser Pro Met Leu Gly Asn Ala Ser Asn Pro Asn Lys 
     450                455                460
Ala Asp Ile Pro Glu Arg Lys Lys Ser Ser Thr Val Pro Ser Ser Asn 
 465                470                475                480
Thr Ala Ser Gly Gly Met Thr Arg Arg Asn Thr Tyr Val Cys Ser Glu 
                 485                490                495
Arg Thr Thr Asp Asp Arg His Ser Val Ile Gln Asn Gly Lys Glu Asn 
             500                505                510
Ser Thr Ile Pro Asp Gln Arg Thr Pro Val Ala Ser Thr His Ser Ile 
         515                520                525
Ser Ser Ala Ala Thr Pro Asp Arg Ile Arg Phe Pro Arg Gly Thr Ala 
     530                535                540
Ser Arg Ser Thr Phe His Gly Gln Pro Arg Glu Arg Arg Thr Ala Thr 
 545                550                555                560
Tyr Asn Gly Pro Pro Ala Ser Pro Ser Leu Ser His Glu Ala Thr Pro 
                 565                570                575
Leu Ser Gln Thr Arg Ser Arg Gly Ser Thr Thr Leu Phe Ser Lys Leu 
             580                585                590
Thr Ser Lys Leu Thr Arg Ser Arg Asn Val Ser Ala Lys Gln Lys Asp 
         595                600                605
Glu Asn Lys Glu Ala Lys Pro Arg Ser Leu Arg Phe Thr Trp Ser Met 
     610                615                620
Lys Thr Thr Ser Ser Met Asp Pro Gly Asp Met Met Arg Glu Ile Arg 
 625                630                635                640
Lys Val Leu Asp Ala Asn Asn Cys Asp Tyr Glu Gln Arg Glu Arg Phe 
                 645                650                655
Leu Leu Phe Cys Val His Gly Asp Gly His Ala Glu Asn Leu Val Gln 
             660                665                670
Trp Glu Met Glu Val Cys Lys Leu Pro Arg Leu Ser Leu Asn Gly Val 
         675                680                685
Arg Phe Lys Arg Ile Ser Gly Thr Ser Ile Ala Phe Lys Asn Ile Ala 
     690                695                700
Ser Lys Ile Ala Asn Glu Leu Lys Leu 
 705                710



<210> 187
<211> 5174
<212> DNA
<213> Rattus norvegicus
<308> AB010467
<400> 187

gggttgagc  gaactgaga  cccaagacc  gcggtgcac  agagccaca  ggaccgctt  60
tgcggctcc  gggagctgg  ctccaagtt  tgggactcc  acctgactg  atataccaa  120
actccagac  tcacaccct  tttccagaa  tccttgctg  cctgggttc  ctgcatcta  180
ctgtgggct  ccttgccct  ctacctgtt  tacctgagg  accatcggc  tggctacat  240
gtcctctca  gcttatcca  gctcaagac  gccctcggt  ttctgctgt  gtgtatctc  300
tgggtggac  tgttctact  cttccatgg  ctggttcac  gctcatccc  tgctcctgt  360
ttctttatc  cacccttgt  ggtggggat  accatgctg  tggccacat  gctaatcca  420
tatgagcgg  ttcggggcg  gcggtcttc  ggtgtgctc  tcatcttct  gctcctgtg  480
gtgatctgt  ccatcatcc  cttccgttc  aagatcctc  tggctttgg  agagggtaa  540
atcttggat  cgttccgat  caccacttt  tacatctac  tcgccctcg  gctgtgtgc  600
ttcatcctg  cctgcttcc  ggagaagcc  cctttgttt  ccccagaga  tcttgacac  660
aatccttgc  cagaggcca  cgctggctt  ttctcccgt  tgtctttct  gtggttcac  720
aagcttgcc  tccttggct  ccgacgtcc  ctggaggac  gtgacctct  gtctctgtc  780
gaggaggac  gctctcaca  ggtggtaca  cggctactg  aagcatggc  aaagcagca  840
acccaagca  cagggcccc  gactgcagc  cttgagcca  agatcgcag  tgaggatga  900
gtcctgctg  aggcccgcc  caagaccaa  aagccttcc  ttctgaggg  tttggtgag  960
accttcacc  ccagcttgc  catgggtgc  tgcttcaag  tgatccagg  cctgctctc  1020
ttcatcaac  cacagctgc  cagcatcct  atcaggttt  tttctgacc  cacggcccc  1080
acctggtgg  gcttcttgc  ggccggact  atgttcgtg  gctccacca  gcagacatt  1140
atcttacac  aacattacc  ctgcatctt  gtgatggcc  tgaggatac  gactgctat  1200
ataggcgtc  tctacagga  ggctctgac  atcaccaac  cagtcaaac  tgagtacac  1260
gtgggagaa  tggtcaacc  catgtcggt  gacgcccag  gcttcatgg  tgtctcccc  1320
ttcatcaac  tgctgtggt  tgcaccttt  caggtcatc  tggcgatat  cttcctctg  1380
cagatctta  gcccatcag  cctggctgg  gtggctgtg  tagtcttgc  gataccact  1440
aatggagct  tgtccatga  aatgaagac  taccaggta  agcaaatga  gttcaaaga  1500
tcccgcatc  aactgatga  tgagatcct  aatggcatc  aagttctga  gctgtacgc  1560
tgggagccc  ccttcttgg  gcaggtaga  ggaatcagg  agggtgagc  ccagctact  1620
cggaagggc  cctacctgc  ggctatctc  accttcatc  gggtctgca  cccgtttat  1680
gtgaccctg  tcaccctcg  ggtgtacgt  tgtgtggac  agaacaatg  gctggatgc  1740
gagaaggcc  tcgtgtccc  gtccttgtt  aatatctta  agatccccc  caacctgct  1800
cctcagtta  tcagtggca  gacccagac  agcgtgtct  tgaaacgga  ccaggattt  1860
ctgaaccaa  atgaacttg  cccccagtg  gtggaaaga  agaccatct  cccaggccg  1920
gccatcacc  tacacaacg  caccttctc  tggtccaag  acctgcctc  cacccttca  1980
agcctaaac  ttcaaatcc  gaagggggc  ttggtggct  tggtgggac  tgtgggctg  2040
gggaagtct  ccctggtgt  tgccttgct  ggagagatg  agaagctgg  aggtgcagt  2100
tctgtaaag  gctctgtgg  ctacgtgcc  cagcaggcg  ggatccaga  ctgcacact  2160
caggaaaat  tgctatttg  ccaacccat  aaccccaag  gctaccaac  ggctctgga  2220
acgtgtgcc  tgctagctg  cctagatgt  cttcctggt  gggaccaga  agagattgg  2280
gagaagggc  ttaacctat  tggaggcca  cgacaacgg  tgagtttgg  ccgagctgt  2340
tatagtgac  ccaacattt  tttgctgga  gacccactg  cggctgtgg  ctctcacgt  2400
gctaagcat  tcttcgacc  agtgattgg  ccagaaggt  tgctggcag  caagactcg  2460
gtgctggta  cccatggca  cagcttcct  ccccagacg  actttatca  tgtgcttgc  2520
gacggacag  ttactgaga  gggtcacta  tccgaactc  tgcagcacg  tggctcctt  2580
gccaacttc  tccgaaact  tgcaccaga  gaaaaccag  aggccaatg  aggagtctt  2640
caacatgca  atgaggagg  gctcctgct  gaagacaca  tcagcaccc  cacagacct  2700
acagacacc  agccagcca  atacgaggt  cgcaagcag  tcatgagag  gatgagctc  2760
ttgtcttct  aaggagagg  ccagaaccg  cctgtgctc  agagatata  gagttcact  2820
gagaaggag  tgccggcga  acagactaa  gagactggt  cattaatca  agaggagat  2880
gcagagaca  gcaatgtga  gctgagcgt  tactgggat  atgccaagt  tgtggggct  2940
tgcaccacg  tgtttatct  cctcctgta  gctggccaa  atgcggttg  tatcggagc  3000
aatgtgtgg  tcagtgcct  gaccaatga  gtggaggaa  atggccagc  gaacaacac  3060
tccgtaagg  tgggagtct  cgccaccct  ggaatactg  aagggctcc  ggtcatgct  3120
tcggccttc  ccatggtgg  tggcgctat  caggctgcc  gcctgctgc  cacagctct  3180
ttgcacaac  agatccgtg  gcctcagtc  ttctttgac  cgacgccct  aggccgcat  3240
ctcaatcgt  tctccaagg  catatacgt  atcgatgag  ttctggccc  caccatcct  3300
atgctgttc  attcattct  cacatccat  tccaccatt  tggtcatcg  ggccagcac  3360
ccactcttc  gcgtggttg  tcttcctct  gctgtgttc  atggcttcg  gcagcgctt  3420
tatgtggcc  catcgaggc  gctgaagag  ctggaatcc  ttagccgct  gcccatctt  3480
tcccacttc  cggagacag  aactggcac  agtgtcatt  gggcctacg  ccgagtcca  3540
gacttcaag  tcctcagtg  tgctaaggt  gatagcaac  agaagacca  ttatcctta  3600
atcgcctcc  accggtggc  gggtgtcca  gtggagttt  tggggaact  cgtggtgct  3660
ttctccgcg  tgtttgcag  gatcgggag  aacagcttg  atccagggc  tgtgggtct  3720
tccgtgtcc  atgccttac  ggtgacctt  agtttgaat  ggatgatac  gacgctatc  3780
gacctggag  ctaatatca  agccgtgga  agagtcaag  agtactcta  gacggagac  3840
gaggctccc  gggtgttgg  gagcaaccg  gctccagaa  gctggccca  gagtggggt  3900
gtagagttc  ggaactatt  ggtgcggta  cgcccgggc  tcgagttgg  gctgaagaa  3960
ttgactctg  atgtgcagg  tggggagaa  gtaggcatc  tgggccgca  tggggctgg  4020
aaatcttcc  tgactcttt  cctattccg  atcctggag  ccgcagagg  tgagatctt  4080
attgacggg  tcaatgtgg  acacattgg  ctccatgac  tgcgttcac  actcaccat  4140
atccctcag  accccatcc  gttctcggg  acgctgcgc  tgaacctcg  tccctttgg  4200
cgttactcg  acgaggaca  ctggaggac  ctggagcta  cccacctga  tgcatttgt  4260
agcagccag  cgacaggcc  ggattttca  tgctctgag  gtggggata  tctcagtgt  4320
ggccagagg  agctcgtgt  cctagcccg  gccctgctc  gaaagagcc  tgtcctggt  4380
ttagacgag  ccaccgctg  cattgacct  gagactgat  acctcatcc  gggtaccat  4440
cgtacccag  ttgaagact  cactgtact  accatcgcc  accggctca  cacaatcat  4500
gactacaac  gggtcctgg  cttggacaa  ggagtagta  ctgaatttg  ttctccagt  4560
aacctcatt  cagctggag  catcttcta  gggatggcc  aagatgcag  actcgccta  4620
aatctgcat  ccaaaggtt  cttccttgt  tgaatcgga  agcaagtag  tgcagcatg  4680
atttgatgg  aacgagtgg  gacatttga  ttggttttg  ttttttttt  ttttttgtt  4740
ttttttttt  tttaaattc  gcaaattgc  ttacagact  gccatactt  acagtggaa  4800
gaggaagtg  gtccttgga  gtcacagcc  gttcacagc  aagttcaga  cagtccctg  4860
gtctcctag  cctagtcta  cattattcc  gtactgcat  tttttttgg  tcttttttt  4920
agagctggg  accgaaccc  gggccttgc  cttcctagg  aagcgctct  ccactgagc  4980
aaatcccca  cccccgtac  gcagttttt  agagaccct  ctcctgcct  tacatattc  5040
tagtttcca  ttttttttt  aaatgagcc  ttctccttc  ggaccaggg  ctgctaggt  5100
agtctgtcc  gggaacaga  tccctggtt  gtgctgtct  aatccactg  cgaaataaa  5160
ccatgagca  cagc  5174



<210> 188
<211> 1522
<212> PRT
<213> Rattus norvegicus
<308> O88563
<400> 188

Met Asp Arg Leu Cys Gly Ser Gly Glu Leu Gly Ser Lys Phe Trp Asp 
  1               5                  10                  15
Ser Asn Leu Thr Val Tyr Thr Asn Thr Pro Asp Leu Thr Pro Cys Phe 
             20                  25                  30
Gln Asn Ser Leu Leu Ala Trp Val Pro Cys Ile Tyr Leu Trp Ala Ala 
         35                  40                  45
Leu Pro Cys Tyr Leu Phe Tyr Leu Arg His His Arg Leu Gly Tyr Ile 
     50                  55                  60
Val Leu Ser Cys Leu Ser Arg Leu Lys Thr Ala Leu Gly Val Leu Leu 
 65                  70                  75                  80
Trp Cys Ile Ser Trp Val Asp Leu Phe Tyr Ser Phe His Gly Leu Val 
                 85                  90                  95
His Gly Ser Ser Pro Ala Pro Val Phe Phe Ile Thr Pro Leu Leu Val 
             100                105                110
Gly Ile Thr Met Leu Leu Ala Thr Leu Leu Ile Gln Tyr Glu Arg Leu 
         115                120                125
Arg Gly Val Arg Ser Ser Gly Val Leu Ile Ile Phe Trp Leu Leu Cys 
     130                135                140
Val Ile Cys Ala Ile Ile Pro Phe Arg Ser Lys Ile Leu Leu Ala Leu 
 145                150                155                160
Ala Glu Gly Lys Ile Leu Asp Pro Phe Arg Phe Thr Thr Phe Tyr Ile 
                 165                170                175
Tyr Phe Ala Leu Val Leu Cys Ala Phe Ile Leu Ser Cys Phe Gln Glu 
             180                185                190
Lys Pro Pro Leu Phe Ser Pro Glu Asn Leu Asp Thr Asn Pro Cys Pro 
         195                200                205
Glu Ala Ser Ala Gly Phe Phe Ser Arg Leu Ser Phe Trp Trp Phe Thr 
     210                215                220
Lys Leu Ala Ile Leu Gly Tyr Arg Arg Pro Leu Glu Asp Ser Asp Leu 
 225                230                235                240
Trp Ser Leu Ser Glu Glu Asp Cys Ser His Lys Val Val Gln Arg Leu 
                 245                250                255
Leu Glu Ala Trp Gln Lys Gln Gln Thr Gln Ala Ser Gly Pro Gln Thr 
             260                265                270
Ala Ala Leu Glu Pro Lys Ile Ala Gly Glu Asp Glu Val Leu Leu Lys 
         275                280                285
Ala Arg Pro Lys Thr Lys Lys Pro Ser Phe Leu Arg Ala Leu Val Arg 
     290                295                300
Thr Phe Thr Ser Ser Leu Leu Met Gly Ala Cys Phe Lys Leu Ile Gln 
 305                310                315                320
Asp Leu Ser Pro Ser Ser Thr His Ser Cys Ser Ala Ser Ser Ser Gly 
                 325                330                335
Leu Phe Arg Pro His Gly Pro Tyr Trp Trp Gly Phe Leu Leu Ala Gly 
             340                345                350
Leu Met Phe Val Ser Ser Thr Met Gln Thr Leu Ile Leu His Gln His 
         355                360                365
Tyr His Cys Ile Phe Val Met Ala Leu Arg Ile Arg Thr Ala Ile Ile 
     370                375                380
Gly Val Ile Tyr Arg Lys Ala Leu Thr Ile Thr Asn Ser Val Lys Arg 
 385                390                395                400
Glu Tyr Thr Val Gly Glu Met Val Asn Leu Met Ser Val Asp Ala Gln 
                 405                410                415
Arg Phe Met Asp Val Ser Pro Phe Ile Asn Leu Leu Trp Ser Ala Pro 
             420                425                430
Leu Gln Val Ile Leu Ala Ile Tyr Phe Leu Trp Gln Ile Leu Gly Pro 
         435                440                445
Ser Ala Leu Ala Gly Val Ala Val Ile Val Leu Leu Ile Pro Leu Asn 
     450                455                460
Gly Ala Val Ser Met Lys Met Lys Thr Tyr Gln Val Gln Gln Met Lys 
 465                470                475                480
Phe Lys Asp Ser Arg Ile Lys Leu Met Ser Glu Ile Leu Asn Gly Ile 
                 485                490                495
Lys Val Leu Lys Leu Tyr Ala Trp Glu Pro Thr Phe Leu Glu Gln Val 
             500                505                510
Glu Gly Ile Arg Gln Gly Glu Leu Gln Leu Leu Arg Lys Gly Ala Tyr 
         515                520                525
Leu Gln Ala Ile Ser Thr Phe Ile Trp Val Cys Thr Pro Phe Met Val 
     530                535                540
Thr Leu Ile Thr Leu Gly Val Tyr Val Cys Val Asp Lys Asn Asn Val 
 545                550                555                560
Leu Asp Ala Glu Lys Ala Phe Val Ser Leu Ser Leu Phe Asn Ile Leu 
                 565                570                575
Lys Ile Pro Leu Asn Leu Leu Pro Gln Leu Ile Ser Gly Met Thr Gln 
             580                585                590
Thr Ser Val Ser Leu Lys Arg Ile Gln Asp Phe Leu Asn Gln Asp Glu 
         595                600                605
Leu Asp Pro Gln Cys Val Glu Arg Lys Thr Ile Ser Pro Gly Arg Ala 
     610                615                620
Ile Thr Ile His Asn Gly Thr Phe Ser Trp Ser Lys Asp Leu Pro Pro 
 625                630                635                640
Thr Leu His Ser Ile Asn Ile Gln Ile Pro Lys Gly Ala Leu Val Ala 
                 645                650                655
Val Val Gly Pro Val Gly Cys Gly Lys Ser Ser Leu Val Ser Ala Leu 
             660                665                670
Leu Gly Glu Met Glu Lys Leu Glu Gly Ala Val Ser Val Lys Gly Ser 
         675                680                685
Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Cys Thr Leu Gln 
     690                695                700
Glu Asn Val Leu Phe Gly Gln Pro Met Asn Pro Lys Arg Tyr Gln Gln 
 705                710                715                720
Ala Leu Glu Thr Cys Ala Leu Leu Ala Asp Leu Asp Val Leu Pro Gly 
                 725                730                735
Gly Asp Gln Thr Glu Ile Gly Glu Lys Gly Ile Asn Leu Ser Gly Gly 
             740                745                750
Gln Arg Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser Asp Ala Asn 
         755                760                765
Ile Phe Leu Leu Asp Asp Pro Leu Ser Ala Val Asp Ser His Val Ala 
     770                775                780
Lys His Ile Phe Asp Gln Val Ile Gly Pro Glu Gly Val Leu Ala Gly 
 785                790                795                800
Lys Thr Arg Val Leu Val Thr His Gly Ile Ser Phe Leu Pro Gln Thr 
                 805                810                815
Asp Phe Ile Ile Val Leu Ala Asp Gly Gln Ile Thr Glu Met Gly His 
             820                825                830
Tyr Ser Glu Leu Leu Gln His Asp Gly Ser Phe Ala Asn Phe Leu Arg 
         835                840                845
Asn Tyr Ala Pro Asp Glu Asn Gln Glu Ala Asn Glu Gly Val Leu Gln 
     850                855                860
His Ala Asn Glu Glu Val Leu Leu Leu Glu Asp Thr Leu Ser Thr His 
 865                870                875                880
Thr Asp Leu Thr Asp Thr Glu Pro Ala Ile Tyr Glu Val Arg Lys Gln 
                 885                890                895
Phe Met Arg Glu Met Ser Ser Leu Ser Ser Glu Gly Glu Gly Gln Asn 
             900                905                910
Arg Pro Val Leu Lys Arg Tyr Thr Ser Ser Leu Glu Lys Glu Val Pro 
         915                920                925
Ala Thr Gln Thr Lys Glu Thr Gly Ala Leu Ile Lys Glu Glu Ile Ala 
     930                935                940
Glu Thr Gly Asn Val Lys Leu Ser Val Tyr Trp Asp Tyr Ala Lys Ser 
 945                950                955                960
Val Gly Leu Cys Thr Thr Leu Phe Ile Cys Leu Leu Tyr Ala Gly Gln 
                 965                970                975
Asn Ala Val Ala Ile Gly Ala Asn Val Trp Leu Ser Ala Trp Thr Asn 
             980                985                990
Asp Val Glu Glu His Gly Gln Gln Asn Asn Thr Ser Val Arg Leu Gly 
         995                1000                1005
Val Tyr Ala Thr Leu Gly Ile Leu Gln Gly Leu Leu Val Met Leu Ser 
     1010                1015                1020
Ala Phe Thr Met Val Val Gly Ala Ile Gln Ala Ala Arg Leu Leu His 
 1025                1030                1035                1040
Thr Ala Leu Leu His Asn Gln Ile Arg Ala Pro Gln Ser Phe Phe Asp 
                 1045                1050                1055
Thr Thr Pro Ser Gly Arg Ile Leu Asn Arg Phe Ser Lys Asp Ile Tyr 
             1060                1065                1070
Val Ile His Glu Val Leu Ala Pro Thr Ile Leu Met Leu Phe Asn Ser 
         1075                1080                1085
Phe Tyr Thr Ser Ile Ser Thr Ile Val Val Ile Val Ala Ser Thr Pro 
     1090                1095                1100
Leu Phe Cys Val Val Val Leu Pro Leu Ala Val Phe Tyr Gly Phe Val 
 1105                1110                1115                1120
Gln Arg Phe Tyr Val Ala Thr Ser Arg Gln Leu Lys Arg Leu Glu Ser 
                 1125                1130                1135
Val Ser Arg Ser Pro Ile Phe Ser His Phe Ser Glu Thr Val Thr Gly 
             1140                1145                1150
Thr Ser Val Ile Arg Ala Tyr Gly Arg Val Gln Asp Phe Lys Val Leu 
         1155                1160                1165
Ser Asp Ala Lys Val Asp Ser Asn Gln Lys Thr Thr Tyr Pro Tyr Ile 
     1170                1175                1180
Ala Ser Asn Arg Trp Leu Gly Val His Val Glu Phe Val Gly Asn Cys 
 1185                1190                1195                1200
Val Val Leu Phe Ser Ala Leu Phe Ala Val Ile Gly Arg Asn Ser Leu 
                 1205                1210                1215
Asn Pro Gly Leu Val Gly Leu Ser Val Ser Tyr Ala Leu Gln Val Thr 
             1220                1225                1230
Leu Ser Leu Asn Trp Met Ile Arg Thr Leu Ser Asp Leu Glu Ser Asn 
         1235                1240                1245
Ile Ile Ala Val Glu Arg Val Lys Glu Tyr Ser Lys Thr Glu Thr Glu 
     1250                1255                1260
Ala Pro Trp Val Leu Glu Ser Asn Arg Ala Pro Glu Gly Trp Pro Arg 
 1265                1270                1275                1280
Ser Gly Val Val Glu Phe Arg Asn Tyr Ser Val Arg Tyr Arg Pro Gly 
                 1285                1290                1295
Leu Glu Leu Val Leu Lys Asn Leu Thr Leu His Val Gln Gly Gly Glu 
             1300                1305                1310
Lys Val Gly Ile Val Gly Arg Thr Gly Ala Gly Lys Ser Ser Met Thr 
         1315                1320                1325
Leu Cys Leu Phe Arg Ile Leu Glu Ala Ala Glu Gly Glu Ile Phe Ile 
     1330                1335                1340
Asp Gly Leu Asn Val Ala His Ile Gly Leu His Asp Leu Arg Ser Gln 
 1345                1350                1355                1360
Leu Thr Ile Ile Pro Gln Asp Pro Ile Leu Phe Ser Gly Thr Leu Arg 
                 1365                1370                1375
Met Asn Leu Asp Pro Phe Gly Arg Tyr Ser Asp Glu Asp Ile Trp Arg 
             1380                1385                1390
Thr Leu Glu Leu Ser His Leu Ser Ala Phe Val Ser Ser Gln Pro Thr 
         1395                1400                1405
Gly Leu Asp Phe Gln Cys Ser Glu Gly Gly Asp Asn Leu Ser Val Gly 
     1410                1415                1420
Gln Arg Gln Leu Val Cys Leu Ala Arg Ala Leu Leu Arg Lys Ser Arg 
 1425                1430                1435                1440
Val Leu Val Leu Asp Glu Ala Thr Ala Ala Ile Asp Leu Glu Thr Asp 
                 1445                1450                1455
Asp Leu Ile Gln Gly Thr Ile Arg Thr Gln Phe Glu Asp Cys Thr Val 
             1460                1465                1470
Leu Thr Ile Ala His Arg Leu Asn Thr Ile Met Asp Tyr Asn Arg Val 
         1475                1480                1485
Leu Val Leu Asp Lys Gly Val Val Ala Glu Phe Asp Ser Pro Val Asn 
     1490                1495                1500
Leu Ile Ala Ala Gly Gly Ile Phe Tyr Gly Met Ala Lys Asp Ala Gly 
 1505                1510                1515                1520
Leu Ala 
                 1525



<210> 189
<211> 3333
<212> DNA
<213> Homo sapiens
<308> AK000791
<400> 189

tagtgggaa  accccaaca  gccttcact  actcaagaa  cacttgcag  acgatggag  60
gggaagggt  ccatggaca  ggcaatggg  cagaccttg  tctcttgga  gtgccccca  120
gcagccagc  gtgtcttgg  agccaagct  agaatgcct  atgctaccc  ctgtctgtt  180
catccctct  ctaccctca  cccccactc  catttagga  cccactggg  gaagggagg  240
tgggcagga  gtgctgagc  ctgggtttg  aggagggac  gggctgggc  gagaggacc  300
gttcccagg  ctaaccaaa  ctgtttcat  caccagcag  cctagggtg  ggggcttgg  360
tggaccttg  aggttggga  ttcattcat  ctagtggaa  aggcagaaa  taatcaaat  420
atcatgtgt  aatagggcc  ataggaagg  cgcaaaggc  tgtgtgtgc  ggccagaaa  480
aggctatcc  cacagggtg  ccaggacac  ttctcctgt  aggaaggga  gcaccagcc  540
ggcctgaaa  aatgagtaa  agttggagg  tggaggtgg  gcaataagg  agggagcga  600
ctgaaaatt  caggcaaag  atataacac  tgccccaag  caggagggt  caggaggct  660
gagtgcgtg  gagggaggc  gtagaacca  gatgggggt  gagaacagg  cgcactctg  720
tgcactttg  ggaccatgg  agagcattc  gtccttacc  aagagcaat  aaaagccgc  780
gaagacctt  attttggag  cagggttgg  atcggcggg  ggggagggg  ggcggtggc  840
aggcagtga  gtcacagac  cagtccttc  caggacaca  ctgggagcc  agtaggctg  900
gaaccagaa  gcagtcagc  ccctcccat  gaggagcac  tctccaggc  ggggagagc  960
ccttcccct  ctgccgtac  ctggtggag  cagcccact  gccttgtac  aggtgcact  1020
ggtgagtgg  tggtgggag  ttctaaccc  gggctcagg  ctagctgtt  gtgtgtgag  1080
tggagaccc  ccgagcagc  gcagcagca  cagcagccg  agcagccgc  accagattt  1140
cagcccaag  cccagattc  agtgtcagc  tcgctgcag  tggtttcct  ccgtgtgct  1200
ttgtgagcc  acacaaagc  gatggatgt  cacagagcc  agcgcacag  cccatggct  1260
cctgcgcac  gcctgctga  gtcctgtga  cccggcaag  ggaagggct  attagggaa  1320
gttttcaga  ccctgacta  cagagatga  taggacctt  tgtttgatc  cagaaactg  1380
ttcacttgc  agaactaac  gaatggcta  aataaccag  cttgcaagt  tgcacatgt  1440
gtgcggtgg  tgtgttggg  gggttggca  gtcactgtg  gcctgagca  gtacccaga  1500
gagcaggat  agacgatgt  accaggtca  ggctgatgg  aacctgacc  cttctctct  1560
ttttgacta  ggtcctggt  ctggacaaa  gagtagtag  tgaatttga  tctccagcc  1620
acctcattg  agctagagg  atcttctac  ggatggcca  agatgctgg  cttgcctaa  1680
atatattcc  gagatttcc  cctggcctt  cctggtttt  atcaggaag  aaatgacac  1740
aaatatgtc  gcagaatgg  cttgatagc  aacactggg  gcaccttaa  attttgcac  1800
tgtaaagtg  cttacaggg  aactgtgct  aatgcttta  atgaggaaa  gatccccaa  1860
tggtgaatg  cacgcctaa  gtcacagct  gtttgagcc  gttagacta  tccccggtc  1920
cccgattcc  aactgagtg  tatttgcac  ctgcactgt  ttcaaataa  gattttatg  1980
aatgacctc  gtcctccct  tgatttttc  tattttcta  agtttcgtt  ctgtttttt  2040
ataaaaagc  ttttcctcc  ggaacagaa  acagctgct  ggtcaggcc  cccctagga  2100
ctcagtcct  tactctggg  tgctgcctg  atccattaa  aatgggagt  ctgatgaaa  2160
aaaactaca  ggtcaacag  atatacaca  tagtctttt  gcacttgtt  acaaggttt  2220
gggattagg  tctttggag  aggccaaga  gaagacttt  tacacatgt  catggttgt  2280
gttacctga  cttcagacc  aagagctct  ggctgcaaa  attgccttc  cagccaaaa  2340
tccctgggt  attgccagt  gctcctgct  tgctgtgca  atattgtaa  acggtgaga  2400
aggccctga  atctgacct  gggcctctt  ggaaagctg  tgtgaacac  tccacgtta  2460
tgtcatccc  cagccctct  tgcctgttt  tctagggac  gagaagtgc  tgatgcttt  2520
acttccttg  tcatttcga  gtctgttcc  gacagttcc  ataaccagt  aggcctccc  2580
aagtgctgg  attacaggc  tgagccact  tgcccagct  caacaatga  attttctaa  2640
acatgggga  gggcacact  ggctccaca  gcactgtct  tgtgcacag  ccacttgca  2700
cctgcctcc  ccatgaggc  atgtaaggg  aactggagg  ttcatgctg  gtcccatca  2760
ttcctaaga  acctgctgg  agagtgcct  catgtccct  accttattg  tgtctcaca  2820
ccactctgg  cacagatga  gaagcaact  aagtggcag  tggaccgtg  cagcaccat  2880
aggagctga  ccttgtggg  agagcactg  gtctggagt  ccaggctgc  gtgtgaccc  2940
gggcaattt  caaaacctt  ctgagcctg  ttcaaatga  aatgatgct  cgtgggatt  3000
tcgtagtca  tgagggctg  gcacagtgg  tcacacctg  aatctcagc  ctttgggag  3060
ccaaggagg  cggatgact  gaggtgagg  gttcaagac  agcctggcc  acatggaga  3120
accctgtct  tactaaaaa  aaaacaaaa  aaaacaaaa  caaaaattt  ccggatgtg  3180
tggtgcatg  ctgtaatct  agctactcg  gaggctgac  gagaattgc  tgaactcag  3240
aagcaaaga  tgcagtgag  caagattac  ccaggacac  ccagtctga  tgacagagg  3300
agacgttgt  tcaaaaaaa  aaaaaaaaa  aaa  3333



<210> 190
<211> 1527
<212> PRT
<213> Homo sapiens
<308> O15438
<400> 190

Met Asp Ala Leu Cys Gly Ser Gly Glu Leu Gly Ser Lys Phe Trp Asp 
  1               5                  10                  15
Ser Asn Leu Ser Val His Thr Glu Asn Pro Asp Leu Thr Pro Cys Phe 
             20                  25                  30
Gln Asn Ser Leu Leu Ala Trp Val Pro Cys Ile Tyr Leu Trp Val Ala 
         35                  40                  45
Leu Pro Cys Tyr Leu Leu Tyr Leu Arg His His Cys Arg Gly Tyr Ile 
     50                  55                  60
Ile Leu Ser His Leu Ser Lys Leu Lys Met Val Leu Gly Val Leu Leu 
 65                  70                  75                  80
Trp Cys Val Ser Trp Ala Asp Leu Phe Tyr Ser Phe His Gly Leu Val 
                 85                  90                  95
His Gly Arg Ala Pro Ala Pro Val Phe Phe Val Thr Pro Leu Val Val 
             100                105                110
Gly Val Thr Met Leu Leu Ala Thr Leu Leu Ile Gln Tyr Glu Arg Leu 
         115                120                125
Gln Gly Val Gln Ser Ser Gly Val Leu Ile Ile Phe Trp Phe Leu Cys 
     130                135                140
Val Val Cys Ala Ile Val Pro Phe Arg Ser Lys Ile Leu Leu Ala Lys 
 145                150                155                160
Ala Glu Gly Glu Ile Ser Asp Pro Phe Arg Phe Thr Thr Phe Tyr Ile 
                 165                170                175
His Phe Ala Leu Val Leu Ser Ala Leu Ile Leu Ala Cys Phe Arg Glu 
             180                185                190
Lys Pro Pro Phe Phe Ser Ala Lys Asn Val Asp Pro Asn Pro Tyr Pro 
         195                200                205
Glu Thr Ser Ala Gly Phe Leu Ser Arg Leu Phe Phe Trp Trp Phe Thr 
     210                215                220
Lys Met Ala Ile Tyr Gly Tyr Arg His Pro Leu Glu Glu Lys Asp Leu 
 225                230                235                240
Trp Ser Leu Lys Glu Glu Asp Arg Ser Gln Met Val Val Gln Gln Leu 
                 245                250                255
Leu Glu Ala Trp Arg Lys Gln Glu Lys Gln Thr Ala Arg His Lys Ala 
             260                265                270
Ser Ala Ala Pro Gly Lys Asn Ala Ser Gly Glu Asp Glu Val Leu Leu 
         275                280                285
Gly Ala Arg Pro Arg Pro Arg Lys Pro Ser Phe Leu Lys Ala Leu Leu 
     290                295                300
Ala Thr Phe Gly Ser Ser Phe Leu Ile Ser Ala Cys Phe Lys Leu Ile 
 305                310                315                320
Gln Asp Leu Leu Ser Phe Ile Asn Pro Gln Leu Leu Ser Ile Leu Ile 
                 325                330                335
Arg Phe Ile Ser Asn Pro Met Ala Pro Ser Trp Trp Gly Phe Leu Val 
             340                345                350
Ala Gly Leu Met Phe Leu Cys Ser Met Met Gln Ser Leu Ile Leu Gln 
         355                360                365
His Tyr Tyr His Tyr Ile Phe Val Thr Gly Val Lys Phe Arg Thr Gly 
     370                375                380
Ile Met Gly Val Ile Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Val 
 385                390                395                400
Lys Arg Ala Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp 
                 405                410                415
Ala Gln Arg Phe Met Asp Leu Ala Pro Phe Leu Asn Leu Leu Trp Ser 
             420                425                430
Ala Pro Leu Gln Ile Ile Leu Ala Ile Tyr Phe Leu Trp Gln Asn Leu 
         435                440                445
Gly Pro Ser Val Leu Ala Gly Val Ala Phe Met Val Leu Leu Ile Pro 
     450                455                460
Leu Asn Gly Ala Val Ala Val Lys Met Arg Ala Phe Gln Val Lys Gln 
 465                470                475                480
Met Lys Leu Lys Asp Ser Arg Ile Lys Leu Met Ser Glu Ile Leu Asn 
                 485                490                495
Gly Ile Lys Val Leu Lys Leu Tyr Ala Trp Glu Pro Ser Phe Leu Lys 
             500                505                510
Gln Val Glu Gly Ile Arg Gln Gly Glu Leu Gln Leu Leu Arg Thr Ala 
         515                520                525
Ala Tyr Leu His Thr Thr Thr Thr Phe Thr Trp Met Cys Ser Pro Phe 
     530                535                540
Leu Val Thr Leu Ile Thr Leu Trp Val Tyr Val Tyr Val Asp Pro Asn 
 545                550                555                560
Asn Val Leu Asp Ala Glu Lys Ala Phe Val Ser Val Ser Leu Phe Asn 
                 565                570                575
Ile Leu Arg Leu Pro Leu Asn Met Leu Pro Gln Leu Ile Ser Asn Leu 
             580                585                590
Thr Gln Ala Ser Val Ser Leu Lys Arg Ile Gln Gln Phe Leu Ser Gln 
         595                600                605
Glu Glu Leu Asp Pro Gln Ser Val Glu Arg Lys Thr Ile Ser Pro Gly 
     610                615                620
Tyr Ala Ile Thr Ile His Ser Gly Thr Phe Thr Trp Ala Gln Asp Leu 
 625                630                635                640
Pro Pro Thr Leu His Ser Leu Asp Ile Gln Val Pro Lys Gly Ala Leu 
                 645                650                655
Val Ala Val Val Gly Pro Val Gly Cys Gly Lys Ser Ser Leu Val Ser 
             660                665                670
Ala Leu Leu Gly Glu Met Glu Lys Leu Glu Gly Lys Val His Met Lys 
         675                680                685
Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Cys Thr 
     690                695                700
Leu Gln Glu Asn Val Leu Phe Gly Lys Ala Leu Asn Pro Lys Arg Tyr 
 705                710                715                720
Gln Gln Thr Leu Glu Ala Cys Ala Leu Leu Ala Asp Leu Glu Met Leu 
                 725                730                735
Pro Gly Gly Asp Gln Thr Glu Ile Gly Glu Lys Gly Ile Asn Leu Ser 
             740                745                750
Gly Gly Gln Arg Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser Asp 
         755                760                765
Ala Asp Ile Phe Leu Leu Asp Asp Pro Leu Ser Ala Val Asp Ser His 
     770                775                780
Val Ala Lys His Ile Phe Asp His Val Ile Gly Pro Glu Gly Val Leu 
 785                790                795                800
Ala Gly Lys Thr Arg Val Leu Val Thr His Gly Ile Ser Phe Leu Pro 
                 805                810                815
Gln Thr Asp Phe Ile Ile Val Leu Ala Asp Gly Gln Val Ser Glu Met 
             820                825                830
Gly Pro Tyr Pro Ala Leu Leu Gln Arg Asn Gly Ser Phe Ala Asn Phe 
         835                840                845
Leu Cys Asn Tyr Ala Pro Asp Glu Asp Gln Gly His Leu Glu Asp Ser 
     850                855                860
Trp Thr Ala Leu Glu Gly Ala Glu Asp Lys Glu Ala Leu Leu Ile Glu 
 865                870                875                880
Asp Thr Leu Ser Asn His Thr Asp Leu Thr Asp Asn Asp Pro Val Thr 
                 885                890                895
Tyr Val Val Gln Lys Gln Phe Met Arg Gln Leu Ser Ala Leu Ser Ser 
             900                905                910
Asp Gly Glu Gly Gln Gly Arg Pro Val Pro Arg Arg His Leu Gly Pro 
         915                920                925
Ser Glu Lys Val Gln Val Thr Glu Ala Lys Ala Asp Gly Ala Leu Thr 
     930                935                940
Gln Glu Glu Lys Ala Ala Ile Gly Thr Val Glu Leu Ser Val Phe Trp 
 945                950                955                960
Asp Tyr Ala Lys Ala Val Gly Leu Cys Thr Thr Leu Ala Ile Cys Leu 
                 965                970                975
Leu Tyr Val Gly Gln Ser Ala Ala Ala Ile Gly Ala Asn Val Trp Leu 
             980                985                990
Ser Ala Trp Thr Asn Asp Ala Met Ala Asp Ser Arg Gln Asn Asn Thr 
         995                1000                1005
Ser Leu Arg Leu Gly Val Tyr Ala Ala Leu Gly Ile Leu Gln Gly Phe 
     1010                1015                1020
Leu Val Met Leu Ala Ala Met Ala Met Ala Ala Gly Gly Ile Gln Ala 
 1025                1030                1035                1040
Ala Arg Val Leu His Gln Ala Leu Leu His Asn Lys Ile Arg Ser Pro 
                 1045                1050                1055
Gln Ser Phe Phe Asp Thr Thr Pro Ser Gly Arg Ile Leu Asn Cys Phe 
             1060                1065                1070
Ser Lys Asp Ile Tyr Val Val Asp Glu Val Leu Ala Pro Val Ile Leu 
         1075                1080                1085
Met Leu Leu Asn Ser Phe Phe Asn Ala Ile Ser Thr Leu Val Val Ile 
     1090                1095                1100
Met Ala Ser Thr Pro Leu Phe Thr Val Val Ile Leu Pro Leu Ala Val 
 1105                1110                1115                1120
Leu Tyr Thr Leu Val Gln Arg Phe Tyr Ala Ala Thr Ser Arg Gln Leu 
                 1125                1130                1135
Lys Arg Leu Glu Ser Val Ser Arg Ser Pro Ile Tyr Ser His Phe Ser 
             1140                1145                1150
Glu Thr Val Thr Gly Ala Ser Val Ile Arg Ala Tyr Asn Arg Ser Arg 
         1155                1160                1165
Asp Phe Glu Ile Ile Ser Asp Thr Lys Val Asp Ala Asn Gln Arg Ser 
     1170                1175                1180
Cys Tyr Pro Tyr Ile Ile Ser Asn Arg Trp Leu Ser Ile Gly Val Glu 
 1185                1190                1195                1200
Phe Val Gly Asn Cys Val Val Leu Phe Ala Ala Leu Phe Ala Val Ile 
                 1205                1210                1215
Gly Arg Ser Ser Leu Asn Pro Gly Leu Val Gly Leu Ser Val Ser Tyr 
             1220                1225                1230
Ser Leu Gln Val Thr Phe Ala Leu Asn Trp Met Ile Arg Met Met Ser 
         1235                1240                1245
Asp Leu Glu Ser Asn Ile Val Ala Val Glu Arg Val Lys Glu Tyr Ser 
     1250                1255                1260
Lys Thr Glu Thr Glu Ala Pro Trp Val Val Glu Gly Ser Arg Pro Pro 
 1265                1270                1275                1280
Glu Gly Trp Pro Pro Arg Gly Glu Val Glu Phe Arg Asn Tyr Ser Val 
                 1285                1290                1295
Arg Tyr Arg Pro Gly Leu Asp Leu Val Leu Arg Asp Leu Ser Leu His 
             1300                1305                1310
Val His Gly Gly Glu Lys Val Gly Ile Val Gly Arg Thr Gly Ala Gly 
         1315                1320                1325
Lys Ser Ser Met Thr Leu Cys Leu Phe Arg Ile Leu Glu Ala Ala Lys 
     1330                1335                1340
Gly Glu Ile Arg Ile Asp Gly Leu Asn Val Ala Asp Ile Gly Leu His 
 1345                1350                1355                1360
Asp Leu Arg Ser Gln Leu Thr Ile Ile Pro Gln Asp Pro Ile Leu Phe 
                 1365                1370                1375
Ser Gly Thr Leu Arg Met Asn Leu Asp Pro Phe Gly Ser Tyr Ser Glu 
             1380                1385                1390
Glu Asp Ile Trp Trp Ala Leu Glu Leu Ser His Leu His Thr Phe Val 
         1395                1400                1405
Ser Ser Gln Pro Ala Gly Leu Asp Phe Gln Cys Ser Glu Gly Gly Glu 
     1410                1415                1420
Asn Leu Ser Val Gly Gln Arg Gln Leu Val Cys Leu Ala Arg Ala Leu 
 1425                1430                1435                1440
Leu Arg Lys Ser Arg Ile Leu Val Leu Asp Glu Ala Thr Ala Ala Ile 
                 1445                1450                1455
Asp Leu Glu Thr Asp Asn Leu Ile Gln Ala Thr Ile Arg Thr Gln Phe 
             1460                1465                1470
Asp Thr Cys Thr Val Leu Thr Ile Ala His Arg Leu Asn Thr Ile Met 
         1475                1480                1485
Asp Tyr Thr Arg Val Leu Val Leu Asp Lys Gly Val Val Ala Glu Phe 
     1490                1495                1500
Asp Ser Pro Ala Asn Leu Ile Ala Ala Arg Gly Ile Phe Tyr Gly Met 
 1505                1510                1515                1520
Ala Arg Asp Ala Gly Leu Ala 
                 1525



<210> 191
<211> 1575
<212> DNA
<213> Rattus norvegicus
<308> AB010743
<400> 191

atcgcttgc  tcttgggca  ccaccgccg  cgtcggacc  agccgtctg  actcctgtg  60
tctcctgtg  attctcctg  ggtccggac  caatagtat  atctttaag  gtttcgtct  120
ccagacatt  tctatggga  atcaagggg  tcaggccat  atagccact  gcagctttg  180
agaacggga  acctttaga  aagcttgat  ttggaggcc  cagcgtgag  cctcaaagc  240
ccctcccga  tccggcaga  ttcctctgt  tcgtcttga  gattgaagg  ccccactgc  300
tcagttttt  tccatcttc  gggaggtag  aggaagtca  aatcatggt  ggtttcaag  360
ccaccgatg  gccccccac  gccaccgtg  agttcctgg  ggctgggac  gcagcctgt  420
ttgcagatc  catcacttt  cctctagac  ccgccaaag  ccggctgca  atccaagga  480
agagtcaag  gctagcgcg  accgccgcc  gcgcccagt  ccgcggcgt  ctgggcacc  540
tcctaacca  ggtgcgcac  gagggtccg  gcagcctct  caatgggct  gtcgccggc  600
tacagcgcc  gatgagctt  gcctccgtc  gcattggcc  ctacgactc  gtaaagcag  660
tctacacca  gggctcaga  catgcaggc  ttgggagcc  cctcctggc  ggtagcacc  720
caggtgccc  ggctgtggc  gtggcccaa  ctacagatg  ggtaaaggt  cgcttccag  780
cccaggccc  ggctggcgg  ggtcggaga  accagagca  tgtcgaagc  tacaagacc  840
ttgcacgag  ggaagggat  cggggcctc  ggaaaggga  ctctcccaa  gttgcccga  900
atgccattg  caactgtac  gagctggtg  cctatgacc  catcaaaga  actctcctg  960
aagccaacc  catgacaga  gacctccct  gccacttca  ttctgcctt  ggggcgggc  1020
tctgcacca  cgtcattgc  tcccccgtt  atgtggtca  gacgagata  atgaactct  1080
ccttgggcc  gtaccacag  gccggccac  gtgccctga  catgctccg  aaggagggg  1140
cccgaacct  ctacaaggg  ttcatgcct  ccttcctcc  cttgggatc  tggaacgta  1200
taatgtttg  cacctatga  cagctcaaa  gggccctga  ggctgccta  gaatcccgg  1260
aggcaccct  ttgagcctc  ccagctgat  acctggacc  tgctcccca  tcctgccct  1320
tcttttcct  catcctctg  ccagcccca  cctcttccc  tttcccaca  tccaactcc  1380
ttcccagct  atctcccta  acctcctca  caaggaggc  ttaccctag  acatctcac  1440
atgcctcct  agcgaggag  cctgacccc  gaccctgca  cctcagtcc  gctaacagt  1500
aagcccaaa  cttttgtcc  cattcccag  ccagcttag  cagccttcg  ccataaagc  1560
agctccaat  taaaa  1575



<210> 192
<211> 309
<212> PRT
<213> Rattus norvegicus
<308> P56500
<400> 192

Met Val Gly Phe Lys Ala Thr Asp Val Pro Pro Thr Ala Thr Val Lys 
  1               5                  10                  15
Phe Leu Gly Ala Gly Thr Ala Ala Cys Ile Ala Asp Leu Ile Thr Phe 
             20                  25                  30
Pro Leu Asp Thr Ala Lys Val Arg Leu Gln Ile Gln Gly Glu Ser Gln 
         35                  40                  45
Gly Leu Ala Arg Thr Ala Ala Ser Ala Gln Tyr Arg Gly Val Leu Gly 
     50                  55                  60
Thr Ile Leu Thr Met Val Arg Thr Glu Gly Pro Arg Ser Leu Tyr Asn 
 65                  70                  75                  80
Gly Leu Val Ala Gly Leu Gln Arg Gln Met Ser Phe Ala Ser Val Arg 
                 85                  90                  95
Ile Gly Leu Tyr Asp Ser Val Lys Gln Phe Tyr Thr Lys Gly Ser Glu 
             100                105                110
His Ala Gly Ile Gly Ser Arg Leu Leu Ala Gly Ser Thr Thr Gly Ala 
         115                120                125
Leu Ala Val Ala Val Ala Gln Pro Thr Asp Val Val Lys Val Arg Phe 
     130                135                140
Gln Ala Gln Ala Arg Ala Gly Gly Gly Arg Arg Tyr Gln Ser Thr Val 
 145                150                155                160
Glu Ala Tyr Lys Thr Ile Ala Arg Glu Glu Gly Ile Arg Gly Leu Trp 
                 165                170                175
Lys Gly Thr Ser Pro Asn Val Ala Arg Asn Ala Ile Val Asn Cys Thr 
             180                185                190
Glu Leu Val Thr Tyr Asp Leu Ile Lys Asp Thr Leu Leu Lys Ala Asn 
         195                200                205
Leu Met Thr Asp Asp Leu Pro Cys His Phe Thr Ser Ala Phe Gly Ala 
     210                215                220
Gly Phe Cys Thr Thr Val Ile Ala Ser Pro Val Asp Val Val Lys Thr 
 225                230                235                240
Arg Tyr Met Asn Ser Ala Leu Gly Gln Tyr His Ser Ala Gly His Cys 
                 245                250                255
Ala Leu Thr Met Leu Arg Lys Glu Gly Pro Arg Ala Phe Tyr Lys Gly 
             260                265                270
Phe Met Pro Ser Phe Leu Arg Leu Gly Ser Trp Asn Val Val Met Phe 
         275                280                285
Val Thr Tyr Glu Gln Leu Lys Arg Ala Leu Met Ala Ala Tyr Glu Ser 
     290                295                300
Arg Glu Ala Pro Phe 
 305



<210> 193
<211> 1104
<212> DNA
<213> Homo sapiens
<308> AF011449
<400> 193

cagccccac  gctgcactg  agcccaggg  tgtggagca  cctctctcc  tggacctcc  60
ctcggccct  aagggactg  gcagagcct  ccaggacta  ggttggact  aagccttca  120
acgtgcctc  caccatggc  gtgaagttc  tgggggcag  cacagcagc  tgttttgct  180
acctcgtta  ctttccact  gacacagcc  aggtccgcc  gcagatcca  ggggagaac  240
aggcggtcc  gacggcccg  ctcgtgcag  accgtggcg  gctgggcac  atcctgacc  300
tggtgcgga  tgagggtcc  tgcagcccc  acaatgggc  ggtggccgg  ctgcagcgc  360
agatgagct  cgcctccat  cgcatcggc  tctacgact  cgtcaagca  gtgtacacc  420
ccaaaggcg  ggacaactc  agcctcact  cccggattt  ggccggctg  accacagga  480
ccatggcgg  gacctgtgc  cagcccaca  atgtggtga  ggtccgatt  caggccagc  540
tacacctcg  gccatccag  agcgacaga  aatacagcg  gactatgga  gcctacaga  600
ccatcgcca  ggaggaagg  gtcaggggc  tgtggaaag  aactttgcc  aacatcatg  660
ggaatgcta  cgtcaactg  gctgaggtg  tgacctacg  catcctcaa  gagaagctg  720
tggactatc  cctgctcac  gacaacttc  cctgccact  tgtctctgc  tttggagcc  780
gcttctgtg  cacagtggt  gcctccccg  tggacgtgg  gaagacccg  tatatgaac  840
cacctccag  ccagtactt  agccccctc  actgtatga  aaagatggt  gcccaggag  900
gccccacag  cttctacaa  ggatttaca  cctcctttt  gcgtttggg  tcctggaac  960
tggtgatgt  cgtaaccta  gagcagctg  aacgggccc  gatgaaagt  cagatgtta  1020
gggaatcac  gttttgaac  agacaagaa  gccactggt  gctaacgtg  ccgaaacca  1080
ttaagaatg  aagaaaacg  tgca  1104



<210> 194
<211> 312
<212> PRT
<213> Homo sapiens
<308> P55916
<400> 194

Met Val Gly Leu Lys Pro Ser Asp Val Pro Pro Thr Met Ala Val Lys 
  1               5                  10                  15
Phe Leu Gly Ala Gly Thr Ala Ala Cys Phe Ala Asp Leu Val Thr Phe 
             20                  25                  30
Pro Leu Asp Thr Ala Lys Val Arg Leu Gln Ile Gln Gly Glu Asn Gln 
         35                  40                  45
Ala Val Gln Thr Ala Arg Leu Val Gln Tyr Arg Gly Val Leu Gly Thr 
     50                  55                  60
Ile Leu Thr Met Val Arg Thr Glu Gly Pro Cys Ser Pro Tyr Asn Gly 
 65                  70                  75                  80
Leu Val Ala Gly Leu Gln Arg Gln Met Ser Phe Ala Ser Ile Arg Ile 
                 85                  90                  95
Gly Leu Tyr Asp Ser Val Lys Gln Val Tyr Thr Pro Lys Gly Ala Asp 
             100                105                110
Asn Ser Ser Leu Thr Thr Arg Ile Leu Ala Gly Cys Thr Thr Gly Ala 
         115                120                125
Met Ala Val Thr Cys Ala Gln Pro Thr Asp Val Val Lys Val Arg Phe 
     130                135                140
Gln Ala Ser Ile His Leu Gly Pro Ser Arg Ser Asp Arg Lys Tyr Ser 
 145                150                155                160
Gly Thr Met Asp Ala Tyr Arg Thr Ile Ala Arg Glu Glu Gly Val Arg 
                 165                170                175
Gly Leu Trp Lys Gly Thr Leu Pro Asn Ile Met Arg Asn Ala Ile Val 
             180                185                190
Asn Cys Ala Glu Val Val Thr Tyr Asp Ile Leu Lys Glu Lys Leu Leu 
         195                200                205
Asp Tyr His Leu Leu Thr Asp Asn Phe Pro Cys His Phe Val Ser Ala 
     210                215                220
Phe Gly Ala Gly Phe Cys Ala Thr Val Val Ala Ser Pro Val Asp Val 
 225                230                235                240
Val Lys Thr Arg Tyr Met Asn Ser Pro Pro Gly Gln Tyr Phe Ser Pro 
                 245                250                255
Leu Asp Cys Met Ile Lys Met Val Ala Gln Glu Gly Pro Thr Ala Phe 
             260                265                270
Tyr Lys Gly Phe Thr Pro Ser Phe Leu Arg Leu Gly Ser Trp Asn Val 
         275                280                285
Val Met Phe Val Thr Tyr Glu Gln Leu Lys Arg Ala Leu Met Lys Val 
     290                295                300
Gln Met Leu Arg Glu Ser Pro Phe 
 305                310



<210> 195
<211> 1444
<212> DNA
<213> Rattus norvegicus
<308> AB010960
<400> 195

ccagacagg  tagccggtt  actacttga  ccagtgcct  cgagtcctc  ccccaccat  60
aggctgtaa  tcgagccgt  cgccgccca  ccccttccc  ctccgcccc  gctctgcga  120
ccaggtccc  acgtcgcgc  gccccttgt  gccctaact  gactgcaaa  ctgccatgg  180
ctggcgggc  tgtctccgt  cggaggcgt  cggcgctgt  cagggccgc  ggttggggg  240
tgtcctgag  gggttgtgt  ttctctccg  gctggcgtt  ctggaatgg  tagggtcgc  300
gacagagac  gcctggaat  cagctcagg  aaatgtgga  gcgccagat  tgggcggct  360
cactcccca  gtacccagc  tattgtcca  gctggtaac  cgaagacgc  gctacacgc  420
gacaccggc  aggctgcgt  gggaccact  caacctcac  tacaggatt  tctcctttc  480
ccggaacct  ttaagcccg  aagagactc  gcggggcct  gcggctgcc  ttcgaatgt  540
gagtgatgt  tccccattc  gcttccgtg  ggtggcccc  gaacgtccc  gtgacctca  600
gataggttt  tacccagtt  accacaccg  ctgcttggt  tctgccctg  accactgct  660
cgatggtcc  acaggtgaa  tggcccacg  tttcttccc  ccccacggt  gcattcatt  720
tgatgacag  gagtactgg  tcttgggtc  cacgcgcta  agctggaag  aaggtgttt  780
gctcacaga  ctggtgcac  tggcagccc  tgagattgg  catgcactg  gactgatgc  840
ctcacagca  gaccaggca  tcatgcacc  caatgccac  ttgcgaggc  ggaaggcac  900
gtcccagga  gagctgtgg  gactacacc  actctatgg  tgcctggac  ggatttttg  960
gtgtacatc  tgggcacga  agggatttt  tgatgtccg  cagaggctc  tgaagaggc  1020
ctgccccag  agctgtgat  tctgttacg  attcccatt  cccacggtt  ccaccacca  1080
atcacccac  agaacgaaa  cgaggttcg  gagagaggg  aggaacatg  ccttccact  1140
tggacagaa  atcctacac  agaaaggca  agtatactg  tacaaggac  aggaacccc  1200
ggagttctc  taccctggc  atctggccc  gggtgaggc  cggctgagc  tcattgcca  1260
tgcagtcaa  gaaggcacc  acacatgtg  ggtacgcca  cgccagcgt  ttctcacca  1320
ctactcctg  agggtccga  tgaggagct  agccagctc  agcctctgt  ctggaagcc  1380
gcagataaa  cactttctc  ctgaaaaaa  aaaaaaaaa  aaaaagaaa  aaaaaaaaa  1440
aaaa  1444



<210> 196
<211> 391
<212> PRT
<213> Rattus norvegicus
<308> BAA24832
<400> 196

Met Gly Trp Arg Ala Cys Leu Arg Pro Glu Ala Ser Gly Ala Val Gln 
  1               5                  10                  15
Gly Arg Trp Leu Gly Ala Val Leu Ser Gly Leu Cys Leu Leu Ser Ala 
             20                  25                  30
Leu Ala Phe Leu Glu Trp Leu Gly Ser Pro Thr Glu Thr Ala Trp Asn 
         35                  40                  45
Ala Ala Gln Gly Asn Val Asp Ala Pro Asp Val Gly Gly Ser Thr Pro 
     50                  55                  60
Gln Val Pro Ser Leu Leu Ser Met Leu Val Thr Arg Arg Arg Arg Tyr 
 65                  70                  75                  80
Thr Leu Thr Pro Ala Arg Leu Arg Trp Asp His Phe Asn Leu Thr Tyr 
                 85                  90                  95
Arg Ile Leu Ser Phe Pro Arg Asn Leu Leu Ser Pro Glu Glu Thr Arg 
             100                105                110
Arg Gly Leu Ala Ala Ala Phe Arg Met Trp Ser Asp Val Ser Pro Phe 
         115                120                125
Ser Phe Arg Glu Val Ala Pro Glu Arg Pro Ser Asp Leu Lys Ile Gly 
     130                135                140
Phe Tyr Pro Val Asn His Thr Asp Cys Leu Val Ser Ala Leu His His 
 145                150                155                160
Cys Phe Asp Gly Pro Thr Gly Glu Leu Ala His Ala Phe Phe Pro Pro 
                 165                170                175
His Gly Gly Ile His Phe Asp Asp Ser Glu Tyr Trp Val Leu Gly Pro 
             180                185                190
Thr Arg Tyr Ser Trp Lys Lys Gly Val Trp Leu Thr Asp Leu Val His 
         195                200                205
Val Ala Ala His Glu Ile Gly His Ala Leu Gly Leu Met His Ser Gln 
     210                215                220
Gln Asp Gln Ala Leu Met His Leu Asn Ala Thr Leu Arg Gly Trp Lys 
 225                230                235                240
Ala Leu Ser Gln Asp Glu Leu Trp Gly Leu His Arg Leu Tyr Gly Cys 
                 245                250                255
Leu Asp Arg Ile Phe Val Cys Thr Ser Trp Ala Arg Lys Gly Phe Cys 
             260                265                270
Asp Val Arg Gln Arg Leu Met Lys Arg Leu Cys Pro Arg Ser Cys Asp 
         275                280                285
Phe Cys Tyr Glu Phe Pro Phe Pro Thr Val Ala Thr Thr Thr Ser Pro 
     290                295                300
Thr Arg Thr Lys Thr Arg Phe Val Arg Glu Gly Arg Asn Met Thr Phe 
 305                310                315                320
His Cys Gly Gln Lys Ile Leu His Lys Lys Gly Lys Val Tyr Trp Tyr 
                 325                330                335
Lys Asp Gln Glu Pro Leu Glu Phe Ser Tyr Pro Gly Tyr Leu Ala Leu 
             340                345                350
Gly Glu Ala Arg Leu Ser Ile Ile Ala Asn Ala Val Asn Glu Gly Thr 
         355                360                365
Tyr Thr Cys Val Val Arg His Arg Gln Arg Val Leu Thr Thr Tyr Ser 
     370                375                380
Trp Arg Val Arg Val Arg Ser 
 385                390



<210> 197
<211> 1212
<212> DNA
<213> Homo sapiens
<308> AB010961
<400> 197

agccctgag  cccatagca  gtctgccat  ggccgcggg  cccgtgtcc  ctcggaggc  60
ccgggggca  gcgtcgagc  ccgctggct  ggagccgcg  tggtcgccc  gtgcctcct  120
cccgcgctg  tgctgctgg  ccggctggg  gccccggcg  tgccggcct  gagcgcagc  180
cagggagac  tcgctgcgc  gggcctctc  gcggtcccc  ccacccggg  cccgggccc  240
ctggccccc  gcagacgcc  ctacacgct  actccagcc  ggctgcgct  ggaccactt  300
aacctcacc  acaggatcc  ctccttccc  cggaacctg  tgagcccgc  ggagacgcg  360
cgggcccta  ctgccgcct  ccgcatgtg  agcgacgtg  cccccttca  cttccgcga  420
gtggccccc  agcagccca  cgacctccg  ataggcttc  acccgatca  ccacacgga  480
tgcctggtc  ccgcgctgc  ccactgctt  gacggcccc  cgggggagc  ggcccacgc  540
ttcttcccc  cgcacggcg  catccactt  gacgacagc  agtactggg  cctgggccc  600
acgcgctac  gctggaaga  aggcgtgtg  ctcacggac  tggtgcacg  ggcggccca  660
gagatcggc  acgcgctgg  cctgatgca  tcacaacac  gccgggcgc  catgcacct  720
aacgccacg  tgcgcggct  gaaggcgtt  tcccaggac  agctgtggg  gctgcaccg  780
ctctacgga  gcctcgaca  gctgttcgt  tgcgcgtcc  gggcgcgga  gggcttctg  840
gacgctcgc  ggcggctca  gaagaggct  tgccccagc  gctgcgact  ctgctacga  900
ttccccttc  ccacggtgg  caccacccc  ccgcccccc  ggaccaaaa  caggctggt  960
cccgagggc  ggaacgtga  cttccgctg  ggccagaag  tcctccaca  gaaagggaa  1020
gtgtactgg  acaaggacc  ggagcccct  gagttctcc  accccggct  cctggccct  1080
ggcgaggcg  acctgagca  catcgccaa  gccgtcaat  agggcacct  cacctgcgt  1140
gtgcgccgc  agcagcgcg  gctgaccac  tactcctgg  gagtccgtg  gcggggctg  1200
gcccggctg  ta  1212



<210> 198
<211> 390
<212> PRT
<213> Homo sapiens
<308> BAA24833
<400> 198

Met Gly Arg Gly Ala Arg Val Pro Ser Glu Ala Pro Gly Ala Gly Val 
  1               5                  10                  15
Glu Arg Arg Trp Leu Gly Ala Ala Leu Val Ala Leu Cys Leu Leu Pro 
             20                  25                  30
Ala Leu Val Leu Leu Ala Arg Leu Gly Ala Pro Ala Val Pro Ala Trp 
         35                  40                  45
Ser Ala Ala Gln Gly Asp Val Ala Ala Leu Gly Leu Ser Ala Val Pro 
     50                  55                  60
Pro Thr Arg Val Pro Gly Pro Leu Ala Pro Arg Arg Arg Arg Tyr Thr 
 65                  70                  75                  80
Leu Thr Pro Ala Arg Leu Arg Trp Asp His Phe Asn Leu Thr Tyr Arg 
                 85                  90                  95
Ile Leu Ser Phe Pro Arg Asn Leu Leu Ser Pro Arg Glu Thr Arg Arg 
             100                105                110
Ala Leu Ala Ala Ala Phe Arg Met Trp Ser Asp Val Ser Pro Phe Ser 
         115                120                125
Phe Arg Glu Val Ala Pro Glu Gln Pro Ser Asp Leu Arg Ile Gly Phe 
     130                135                140
Tyr Pro Ile Asn His Thr Asp Cys Leu Val Ser Ala Leu His His Cys 
 145                150                155                160
Phe Asp Gly Pro Thr Gly Glu Leu Ala His Ala Phe Phe Pro Pro His 
                 165                170                175
Gly Gly Ile His Phe Asp Asp Ser Glu Tyr Trp Val Leu Gly Pro Thr 
             180                185                190
Arg Tyr Ser Trp Lys Lys Gly Val Trp Leu Thr Asp Leu Val His Val 
         195                200                205
Ala Ala His Glu Ile Gly His Ala Leu Gly Leu Met His Ser Gln His 
     210                215                220
Gly Arg Ala Leu Met His Leu Asn Ala Thr Leu Arg Gly Trp Lys Ala 
 225                230                235                240
Leu Ser Gln Asp Glu Leu Trp Gly Leu His Arg Leu Tyr Gly Cys Leu 
                 245                250                255
Asp Arg Leu Phe Val Cys Ala Ser Trp Ala Arg Arg Gly Phe Cys Asp 
             260                265                270
Ala Arg Arg Arg Leu Met Lys Arg Leu Cys Pro Ser Ser Cys Asp Phe 
         275                280                285
Cys Tyr Glu Phe Pro Phe Pro Thr Val Ala Thr Thr Pro Pro Pro Pro 
     290                295                300
Arg Thr Lys Thr Arg Leu Val Pro Glu Gly Arg Asn Val Thr Phe Arg 
 305                310                315                320
Cys Gly Gln Lys Ile Leu His Lys Lys Gly Lys Val Tyr Trp Tyr Lys 
                 325                330                335
Asp Gln Glu Pro Leu Glu Phe Ser Tyr Pro Gly Tyr Leu Ala Leu Gly 
             340                345                350
Glu Ala His Leu Ser Ile Ile Ala Asn Ala Val Asn Glu Gly Thr Tyr 
         355                360                365
Thr Cys Val Val Arg Arg Gln Gln Arg Val Leu Thr Thr Tyr Ser Trp 
     370                375                380
Arg Val Arg Val Arg Gly 
 385                390



<210> 199
<211> 1444
<212> DNA
<213> Rattus norvegicus
<308> AB010960
<400> 199

ccagacagg  tagccggtt  actacttga  ccagtgcct  cgagtcctc  ccccaccat  60
aggctgtaa  tcgagccgt  cgccgccca  ccccttccc  ctccgcccc  gctctgcga  120
ccaggtccc  acgtcgcgc  gccccttgt  gccctaact  gactgcaaa  ctgccatgg  180
ctggcgggc  tgtctccgt  cggaggcgt  cggcgctgt  cagggccgc  ggttggggg  240
tgtcctgag  gggttgtgt  ttctctccg  gctggcgtt  ctggaatgg  tagggtcgc  300
gacagagac  gcctggaat  cagctcagg  aaatgtgga  gcgccagat  tgggcggct  360
cactcccca  gtacccagc  tattgtcca  gctggtaac  cgaagacgc  gctacacgc  420
gacaccggc  aggctgcgt  gggaccact  caacctcac  tacaggatt  tctcctttc  480
ccggaacct  ttaagcccg  aagagactc  gcggggcct  gcggctgcc  ttcgaatgt  540
gagtgatgt  tccccattc  gcttccgtg  ggtggcccc  gaacgtccc  gtgacctca  600
gataggttt  tacccagtt  accacaccg  ctgcttggt  tctgccctg  accactgct  660
cgatggtcc  acaggtgaa  tggcccacg  tttcttccc  ccccacggt  gcattcatt  720
tgatgacag  gagtactgg  tcttgggtc  cacgcgcta  agctggaag  aaggtgttt  780
gctcacaga  ctggtgcac  tggcagccc  tgagattgg  catgcactg  gactgatgc  840
ctcacagca  gaccaggca  tcatgcacc  caatgccac  ttgcgaggc  ggaaggcac  900
gtcccagga  gagctgtgg  gactacacc  actctatgg  tgcctggac  ggatttttg  960
gtgtacatc  tgggcacga  agggatttt  tgatgtccg  cagaggctc  tgaagaggc  1020
ctgccccag  agctgtgat  tctgttacg  attcccatt  cccacggtt  ccaccacca  1080
atcacccac  agaacgaaa  cgaggttcg  gagagaggg  aggaacatg  ccttccact  1140
tggacagaa  atcctacac  agaaaggca  agtatactg  tacaaggac  aggaacccc  1200
ggagttctc  taccctggc  atctggccc  gggtgaggc  cggctgagc  tcattgcca  1260
tgcagtcaa  gaaggcacc  acacatgtg  ggtacgcca  cgccagcgt  ttctcacca  1320
ctactcctg  agggtccga  tgaggagct  agccagctc  agcctctgt  ctggaagcc  1380
gcagataaa  cactttctc  ctgaaaaaa  aaaaaaaaa  aaaaagaaa  aaaaaaaaa  1440
aaaa  1444



<210> 200
<211> 391
<212> PRT
<213> Rattus norvegicus
<308> BAA24832
<400> 200

Met Gly Trp Arg Ala Cys Leu Arg Pro Glu Ala Ser Gly Ala Val Gln 
  1               5                  10                  15
Gly Arg Trp Leu Gly Ala Val Leu Ser Gly Leu Cys Leu Leu Ser Ala 
             20                  25                  30
Leu Ala Phe Leu Glu Trp Leu Gly Ser Pro Thr Glu Thr Ala Trp Asn 
         35                  40                  45
Ala Ala Gln Gly Asn Val Asp Ala Pro Asp Val Gly Gly Ser Thr Pro 
     50                  55                  60
Gln Val Pro Ser Leu Leu Ser Met Leu Val Thr Arg Arg Arg Arg Tyr 
 65                  70                  75                  80
Thr Leu Thr Pro Ala Arg Leu Arg Trp Asp His Phe Asn Leu Thr Tyr 
                 85                  90                  95
Arg Ile Leu Ser Phe Pro Arg Asn Leu Leu Ser Pro Glu Glu Thr Arg 
             100                105                110
Arg Gly Leu Ala Ala Ala Phe Arg Met Trp Ser Asp Val Ser Pro Phe 
         115                120                125
Ser Phe Arg Glu Val Ala Pro Glu Arg Pro Ser Asp Leu Lys Ile Gly 
     130                135                140
Phe Tyr Pro Val Asn His Thr Asp Cys Leu Val Ser Ala Leu His His 
 145                150                155                160
Cys Phe Asp Gly Pro Thr Gly Glu Leu Ala His Ala Phe Phe Pro Pro 
                 165                170                175
His Gly Gly Ile His Phe Asp Asp Ser Glu Tyr Trp Val Leu Gly Pro 
             180                185                190
Thr Arg Tyr Ser Trp Lys Lys Gly Val Trp Leu Thr Asp Leu Val His 
         195                200                205
Val Ala Ala His Glu Ile Gly His Ala Leu Gly Leu Met His Ser Gln 
     210                215                220
Gln Asp Gln Ala Leu Met His Leu Asn Ala Thr Leu Arg Gly Trp Lys 
 225                230                235                240
Ala Leu Ser Gln Asp Glu Leu Trp Gly Leu His Arg Leu Tyr Gly Cys 
                 245                250                255
Leu Asp Arg Ile Phe Val Cys Thr Ser Trp Ala Arg Lys Gly Phe Cys 
             260                265                270
Asp Val Arg Gln Arg Leu Met Lys Arg Leu Cys Pro Arg Ser Cys Asp 
         275                280                285
Phe Cys Tyr Glu Phe Pro Phe Pro Thr Val Ala Thr Thr Thr Ser Pro 
     290                295                300
Thr Arg Thr Lys Thr Arg Phe Val Arg Glu Gly Arg Asn Met Thr Phe 
 305                310                315                320
His Cys Gly Gln Lys Ile Leu His Lys Lys Gly Lys Val Tyr Trp Tyr 
                 325                330                335
Lys Asp Gln Glu Pro Leu Glu Phe Ser Tyr Pro Gly Tyr Leu Ala Leu 
             340                345                350
Gly Glu Ala Arg Leu Ser Ile Ile Ala Asn Ala Val Asn Glu Gly Thr 
         355                360                365
Tyr Thr Cys Val Val Arg His Arg Gln Arg Val Leu Thr Thr Tyr Ser 
     370                375                380
Trp Arg Val Arg Val Arg Ser 
 385                390



<210> 201
<211> 1212
<212> DNA
<213> Homo sapiens
<308> AB010961
<400> 201

agccctgag  cccatagca  gtctgccat  ggccgcggg  cccgtgtcc  ctcggaggc  60
ccgggggca  gcgtcgagc  ccgctggct  ggagccgcg  tggtcgccc  gtgcctcct  120
cccgcgctg  tgctgctgg  ccggctggg  gccccggcg  tgccggcct  gagcgcagc  180
cagggagac  tcgctgcgc  gggcctctc  gcggtcccc  ccacccggg  cccgggccc  240
ctggccccc  gcagacgcc  ctacacgct  actccagcc  ggctgcgct  ggaccactt  300
aacctcacc  acaggatcc  ctccttccc  cggaacctg  tgagcccgc  ggagacgcg  360
cgggcccta  ctgccgcct  ccgcatgtg  agcgacgtg  cccccttca  cttccgcga  420
gtggccccc  agcagccca  cgacctccg  ataggcttc  acccgatca  ccacacgga  480
tgcctggtc  ccgcgctgc  ccactgctt  gacggcccc  cgggggagc  ggcccacgc  540
ttcttcccc  cgcacggcg  catccactt  gacgacagc  agtactggg  cctgggccc  600
acgcgctac  gctggaaga  aggcgtgtg  ctcacggac  tggtgcacg  ggcggccca  660
gagatcggc  acgcgctgg  cctgatgca  tcacaacac  gccgggcgc  catgcacct  720
aacgccacg  tgcgcggct  gaaggcgtt  tcccaggac  agctgtggg  gctgcaccg  780
ctctacgga  gcctcgaca  gctgttcgt  tgcgcgtcc  gggcgcgga  gggcttctg  840
gacgctcgc  ggcggctca  gaagaggct  tgccccagc  gctgcgact  ctgctacga  900
ttccccttc  ccacggtgg  caccacccc  ccgcccccc  ggaccaaaa  caggctggt  960
cccgagggc  ggaacgtga  cttccgctg  ggccagaag  tcctccaca  gaaagggaa  1020
gtgtactgg  acaaggacc  ggagcccct  gagttctcc  accccggct  cctggccct  1080
ggcgaggcg  acctgagca  catcgccaa  gccgtcaat  agggcacct  cacctgcgt  1140
gtgcgccgc  agcagcgcg  gctgaccac  tactcctgg  gagtccgtg  gcggggctg  1200
gcccggctg  ta  1212



<210> 202
<211> 390
<212> PRT
<213> Homo sapiens
<308> BAA24833
<400> 202

Met Gly Arg Gly Ala Arg Val Pro Ser Glu Ala Pro Gly Ala Gly Val 
  1               5                  10                  15
Glu Arg Arg Trp Leu Gly Ala Ala Leu Val Ala Leu Cys Leu Leu Pro 
             20                  25                  30
Ala Leu Val Leu Leu Ala Arg Leu Gly Ala Pro Ala Val Pro Ala Trp 
         35                  40                  45
Ser Ala Ala Gln Gly Asp Val Ala Ala Leu Gly Leu Ser Ala Val Pro 
     50                  55                  60
Pro Thr Arg Val Pro Gly Pro Leu Ala Pro Arg Arg Arg Arg Tyr Thr 
 65                  70                  75                  80
Leu Thr Pro Ala Arg Leu Arg Trp Asp His Phe Asn Leu Thr Tyr Arg 
                 85                  90                  95
Ile Leu Ser Phe Pro Arg Asn Leu Leu Ser Pro Arg Glu Thr Arg Arg 
             100                105                110
Ala Leu Ala Ala Ala Phe Arg Met Trp Ser Asp Val Ser Pro Phe Ser 
         115                120                125
Phe Arg Glu Val Ala Pro Glu Gln Pro Ser Asp Leu Arg Ile Gly Phe 
     130                135                140
Tyr Pro Ile Asn His Thr Asp Cys Leu Val Ser Ala Leu His His Cys 
 145                150                155                160
Phe Asp Gly Pro Thr Gly Glu Leu Ala His Ala Phe Phe Pro Pro His 
                 165                170                175
Gly Gly Ile His Phe Asp Asp Ser Glu Tyr Trp Val Leu Gly Pro Thr 
             180                185                190
Arg Tyr Ser Trp Lys Lys Gly Val Trp Leu Thr Asp Leu Val His Val 
         195                200                205
Ala Ala His Glu Ile Gly His Ala Leu Gly Leu Met His Ser Gln His 
     210                215                220
Gly Arg Ala Leu Met His Leu Asn Ala Thr Leu Arg Gly Trp Lys Ala 
 225                230                235                240
Leu Ser Gln Asp Glu Leu Trp Gly Leu His Arg Leu Tyr Gly Cys Leu 
                 245                250                255
Asp Arg Leu Phe Val Cys Ala Ser Trp Ala Arg Arg Gly Phe Cys Asp 
             260                265                270
Ala Arg Arg Arg Leu Met Lys Arg Leu Cys Pro Ser Ser Cys Asp Phe 
         275                280                285
Cys Tyr Glu Phe Pro Phe Pro Thr Val Ala Thr Thr Pro Pro Pro Pro 
     290                295                300
Arg Thr Lys Thr Arg Leu Val Pro Glu Gly Arg Asn Val Thr Phe Arg 
 305                310                315                320
Cys Gly Gln Lys Ile Leu His Lys Lys Gly Lys Val Tyr Trp Tyr Lys 
                 325                330                335
Asp Gln Glu Pro Leu Glu Phe Ser Tyr Pro Gly Tyr Leu Ala Leu Gly 
             340                345                350
Glu Ala His Leu Ser Ile Ile Ala Asn Ala Val Asn Glu Gly Thr Tyr 
         355                360                365
Thr Cys Val Val Arg Arg Gln Gln Arg Val Leu Thr Thr Tyr Ser Trp 
     370                375                380
Arg Val Arg Val Arg Gly 
 385                390



<210> 203
<211> 2169
<212> DNA
<213> Rattus norvegicus
<308> AB011369
<400> 203

cgcccgccc  cctccctcc  tctcttgct  ttgggtcgt  gttacccat  gccctttgc  60
gccttggcc  tgtgtctcc  tcgctttct  tgttcctcg  agggcccta  tgggtccca  120
tgccagact  tggcccttc  gcagtgtga  gctgcccga  tgtagaccg  gacacacgc  180
caaggccga  taggactga  ttgcttctg  cctccctcc  tctcccagg  taccccaag  240
tagcgtttc  cggaagcag  agccctttc  gaggggatg  gcgcagcca  gccagatgg  300
cgagaagac  aagaaagca  aggagatgg  cctgagcct  gcccgggca  tgactggcg  360
agatgaaca  gctgcaatc  agtatgcca  ctggctggc  gagcagaag  tacccctca  420
ggtgcaagt  aaacccgag  tttccccaa  acaagacat  aggctttgt  tgagtgtgg  480
agatgctta  atgcacact  tcaccattt  gctcacagt  cgccctgat  tgacagtgg  540
ctcccttaa  gacatggta  tcctggact  tggctttcc  cccagcctg  agcagtggg  600
ggttggaca  aggctggca  gagaccagg  gaccttgca  tcacatggc  ttcgacgga  660
tggagacag  gcttatctc  acctgctgt  agcccgcaa  acatcactc  accctcaag  720
gctgcagcg  cagcggcag  tgcgcatgt  ggaagattt  ggcttcaag  acctcaccc  780
gcagccacg  ggtcccttg  aacctgtcc  tcccaagcc  aggacccac  aggagacgg  840
gcagccaga  gcagcccca  agtcaccac  ggtgggctg  cagtgccct  gctgcacgt  900
catcaacaa  cccacacgg  ctgggtgtg  gatgtgctg  cgtgcaagg  ctgaggcct  960
ccagatccc  gcctcgtac  agcctgatg  ggaggagcg  gcacgcctg  ctggtgagg  1020
ggaggcgct  cgccagtat  agcagggag  gcctgcagg  taccatccg  aacagccag  1080
aggcggagg  atcctgccc  ttcattgac  acacctact  atgccctgg  aagctgctg  1140
agagggaga  ccgggcgct  ctgtcccct  aggactacc  gcgtttcct  gacctgggt  1200
tgtccatcg  agagaatcg  agcaccttg  gctaccact  caagacccc  gactgcagg  1260
gctggtgct  ctttgagga  gacgtcaac  agttcacct  tcctgtgtg  acccgcgtc  1320
actgtctgc  ctgcaaggc  atccacgag  gcatgaatt  cagagagta  caggatgac  1380
tggcccatc  ggctcggaa  gatgtggct  cccagcaga  aactgagat  ctgagggtg  1440
tgctgcagc  aggcgaggc  atgtactgc  cacagtgcc  gattgtggt  cagaagaag  1500
atggctgtg  ctggatccg  tgtactgtc  gccacactg  gatctgctg  gtcaccaag  1560
gtccacgct  gggccctgg  ggcccaggg  acaccagtg  tggctgccg  tgccgggtc  1620
atgggattc  atgccatcc  agctgtcaa  actgccact  agtcaaaga  ggtggctct  1680
agactgacc  agccgcaca  gtatagcag  gaacatcag  gccaggcca  gggctttag  1740
tctggtttg  ccacaatac  ttcaagctt  gtaagggag  aagactgag  tgtactgca  1800
tctgattgc  gtgttacaa  aacccagct  agctgatgt  agccgcact  cctctgttg  1860
ttcaagggc  tgctgacca  acctcatgg  cctgagcta  cttccctac  cttactagc  1920
accagcctt  aacacagcc  tggcctaag  cctggcggc  agtgctctg  gcctcctgg  1980
gactctatt  cccctcagc  tgctccctg  ggacccaca  ccgcatctg  tgccttgct  2040
gctttctgg  tacttttta  agctgatgt  aatccatcc  gggcccagg  agactggta  2100
gtcaggaaa  agcccatgg  gtccagctc  gcatccccc  ctctaagtg  attaaagtg  2160
ttttccagg  2169



<210> 204
<211> 498
<212> PRT
<213> Rattus norvegicus
<308> Q62921
<400> 204

Met Ala Leu Ser Leu Ala Arg Ala Val Thr Gly Gly Asp Glu Gln Ala 
  1               5                  10                  15
Ala Ile Lys Tyr Ala Thr Trp Leu Ala Glu Gln Lys Val Pro Leu Arg 
             20                  25                  30
Val Gln Val Lys Pro Glu Val Ser Pro Thr Gln Asp Ile Arg Leu Cys 
         35                  40                  45
Val Ser Val Glu Asp Ala Tyr Met His Thr Val Thr Ile Trp Leu Thr 
     50                  55                  60
Val Arg Pro Asp Met Thr Val Ala Ser Leu Lys Asp Met Val Phe Leu 
 65                  70                  75                  80
Asp Tyr Gly Phe Pro Pro Ser Leu Gln Gln Trp Val Val Gly Gln Arg 
                 85                  90                  95
Leu Ala Arg Asp Gln Glu Thr Leu His Ser His Gly Ile Arg Arg Asn 
             100                105                110
Gly Asp Ser Ala Tyr Leu Tyr Leu Leu Ser Ala Arg Asn Thr Ser Leu 
         115                120                125
Asn Pro Gln Glu Leu Gln Arg Gln Arg Gln Leu Arg Met Leu Glu Asp 
     130                135                140
Leu Gly Phe Lys Asp Leu Thr Leu Gln Pro Arg Gly Pro Leu Glu Pro 
 145                150                155                160
Val Leu Pro Lys Pro Arg Thr His Gln Glu Thr Gly Gln Pro Asp Ala 
                 165                170                175
Ala Pro Glu Ser Pro Pro Val Gly Trp Gln Cys Pro Gly Cys Thr Phe 
             180                185                190
Ile Asn Lys Pro Thr Arg Pro Gly Cys Glu Met Cys Cys Arg Ala Arg 
         195                200                205
Pro Glu Ala Tyr Gln Ile Pro Ala Ser Tyr Gln Pro Asp Glu Glu Glu 
     210                215                220
Arg Ala Arg Leu Ala Gly Glu Glu Glu Ala Leu Arg Gln Tyr Glu Gln 
 225                230                235                240
Arg Lys Gln Gln Gln Gln Glu Gly Asn Tyr Leu Gln His Val Gln Leu 
                 245                250                255
Glu Gln Arg Ser Leu Val Leu Asn Thr Glu Pro Ala Glu Cys Pro Val 
             260                265                270
Cys Tyr Ser Val Leu Ala Pro Gly Glu Ala Val Val Leu Arg Glu Cys 
         275                280                285
Leu His Thr Phe Cys Arg Glu Cys Leu Gln Gly Thr Ile Arg Asn Ser 
     290                295                300
Gln Glu Ala Glu Val Ser Cys Pro Phe Ile Asp Asn Thr Tyr Ser Cys 
 305                310                315                320
Pro Gly Lys Leu Leu Glu Arg Glu Ile Arg Ala Leu Leu Ser Pro Glu 
                 325                330                335
Asp Tyr Gln Arg Phe Leu Asp Leu Gly Val Ser Ile Ala Glu Asn Arg 
             340                345                350
Ser Thr Leu Ser Tyr His Cys Lys Thr Pro Asp Cys Arg Gly Trp Cys 
         355                360                365
Phe Phe Glu Asp Asp Val Asn Glu Phe Thr Cys Pro Val Cys Thr Arg 
     370                375                380
Val Asn Cys Leu Leu Cys Lys Ala Ile His Glu Arg Met Asn Cys Arg 
 385                390                395                400
Glu Tyr Gln Asp Asp Leu Ala His Arg Ala Arg Asn Asp Val Ala Ala 
                 405                410                415
Gln Gln Thr Thr Glu Met Leu Arg Val Met Leu Gln Gln Gly Glu Ala 
             420                425                430
Met Tyr Cys Pro Gln Cys Arg Ile Val Val Gln Lys Lys Asp Gly Cys 
         435                440                445
Asp Trp Ile Arg Cys Thr Val Cys His Thr Glu Ile Cys Trp Val Thr 
     450                455                460
Lys Gly Pro Arg Trp Gly Pro Gly Gly Pro Gly Asp Thr Ser Gly Gly 
 465                470                475                480
Cys Arg Cys Arg Val Asn Gly Ile Pro Cys His Pro Ser Cys Gln Asn 
                 485                490                495
Cys His 
             500



<210> 205
<211> 2554
<212> DNA
<213> Homo sapiens
<308> NM_031228
<400> 205

gggagtccg  ggacccgcg  tcagccccg  aggacgggg  ggggtcgcc  caaacagga  60
cgccgggac  gctgggacc  cgcactcgg  gtccgccgc  gccgggtag  cgggcagtg  120
aggtcccgg  tgaggcgac  atttttccg  ccccccctc  cagtcccgc  ccacttccg  180
ggccgccac  ttcactttc  cttccgccg  agccgctcc  cttgcgaag  actggggcc  240
cccgggagg  gagagggct  tgccttgaa  cccgggacg  caggggcgc  cccgcaagt  300
ggggtcctc  gggacttgg  acgccccgg  tgggtggtg  ccgggcgtc  tttccccgc  360
tcttcccac  tcggctggt  ccgtttcct  ctgcgccca  tgcggacct  tctcggcgc  420
cgctgccct  tcaccgccc  acgcaggat  ccggcctgg  caccgggca  tgtgatgct  480
cccgactgc  gcggggaca  cgaggcaca  acagggctt  ggccgcgcc  gaggccaca  540
ggcctggct  agttgctcc  ggtctcccg  ctctcccag  cgacccgga  gtagcattt  600
ccaggaggc  cggtccccc  cagggggat  ggcacagcc  cgccagatg  acgagaaga  660
caagaaagc  gaggaaatg  ccctgagcc  cacccgagc  gtggcgggc  gggatgaac  720
ggtggcaat  aagtgtgcc  tctggctgg  agagcaacg  gtgcccctg  gtgtgcaac  780
gaagcctga  gtctcccca  cgcaggaca  caggctgtg  gtgagcgtg  aggatgctc  840
gatgcacac  gtcaccatc  ggctcacag  gcgccctga  atgacagtg  cgtctctca  900
ggacatggt  tttctggac  atggcttcc  accagtctt  cagcagtgg  tgattgggc  960
gcggctggc  cgagaccag  agaccctgc  ctcccatgg  gtgcggcag  atggggaca  1020
tgcctacct  tatctgctg  cagcccgca  cacctccct  aaccctcag  agctgcagc  1080
ggagcggca  ctgcggatg  tggaagatc  gggcttcaa  gacctcacg  tgcagccgc  1140
gggccctct  gagccaggc  ccccaaagc  cggggtccc  caggaaccc  gacgggggc  1200
gccagatgc  gtgcctgag  ccccaccgg  gggctggca  tgccccggg  gcaccttca  1260
caacaagcc  acgcggcct  gctgtgaga  gtgctgccg  gcgcgcccc  aggcctacc  1320
ggtccccgc  tcataccag  ccgacgagg  ggagcgagc  cgcctggcg  gcgaggagg  1380
ggcgctgcg  cagtaccag  agggagtgc  tgcagggca  catccgcaa  agccaggag  1440
cggaggtct  ctgcccctt  attgacaac  cctactcgt  ctcgggcaa  ctgctggag  1500
gggagatca  ggcgctcct  acccctgag  attaccagc  atttctaga  ctgggcatc  1560
ccattgctg  aaaccgcag  gccttcagc  accattgca  gaccccaga  tgcaaggga  1620
ggtgcttct  tgaggatga  gtcaatgag  tcacctgcc  tgtgtgttt  cacgtcaac  1680
gcctgctct  caaggccat  catgagcag  tgaactgca  ggagtatca  gaggacctg  1740
ccctgcggg  tcagaacga  gtggctgcc  ggcagacga  agagatgct  aaggtgatg  1800
tgcagcagg  cgaggccat  cgctgcccc  agtgccaga  cgtggtaca  aagaaggac  1860
gctgcgact  gatccgctg  accgtctgc  acaccgaga  ctgctgggt  accaagggc  1920
cacgctggg  ccctggggg  ccaggagac  ccagcgggg  ctgccgctg  agggtaaat  1980
ggattcctt  ccacccaag  tgtcagaac  gccactgag  taaagatgg  ggggccaca  2040
gctgaccca  ccccacatc  acattctgt  agaatgtag  tcagggagc  tcgtggacg  2100
ccttgcttg  tgtagcgtt  taggggccc  gcctgcact  cggttgtcc  cggtcacat  2160
tgccccagt  cctttgtcc  tcccttggg  cttgccggc  agacttctc  cccctgcgg  2220
tcccacctc  gcctgaccc  agccttaaa  atagcccct  gccagaggc  ttgctgggt  2280
gagcctctg  gtgactcca  actcctccc  ccacaacac  catctgtca  acaccaagc  2340
ctctcagcc  ccccgcctt  agctgtcag  tttctgggg  taacttctc  gcctttgtg  2400
ttggaggcc  gaggcctct  ggaactctt  ctaacctgt  cagagccag  aaggagact  2460
cacagtttt  aaagcacag  ccgtcaggt  cggctctgc  tctccctct  tgcagcctg  2520
gtaagctat  ataattaaa  tggttttcc  ggaa  2554



<210> 206
<211> 500
<212> PRT
<213> Homo sapiens
<308> Q9BYM8
<400> 206

Met Ala Leu Ser Leu Thr Arg Ala Val Ala Gly Gly Asp Glu Gln Val 
  1               5                  10                  15
Ala Met Lys Cys Ala Ile Trp Leu Ala Glu Gln Arg Val Pro Leu Ser 
             20                  25                  30
Val Gln Leu Lys Pro Glu Val Ser Pro Thr Gln Asp Ile Arg Leu Trp 
         35                  40                  45
Val Ser Val Glu Asp Ala Gln Met His Thr Val Thr Ile Trp Leu Thr 
     50                  55                  60
Val Arg Pro Asp Met Thr Val Ala Ser Leu Lys Asp Met Val Phe Leu 
 65                  70                  75                  80
Asp Tyr Gly Phe Pro Pro Val Leu Gln Gln Trp Val Ile Gly Gln Arg 
                 85                  90                  95
Leu Ala Arg Asp Gln Glu Thr Leu His Ser His Gly Val Arg Gln Asn 
             100                105                110
Gly Asp Ser Ala Tyr Leu Tyr Leu Leu Ser Ala Arg Asn Thr Ser Leu 
         115                120                125
Asn Pro Gln Glu Leu Gln Arg Glu Arg Gln Leu Arg Met Leu Glu Asp 
     130                135                140
Leu Gly Phe Lys Asp Leu Thr Leu Gln Pro Arg Gly Pro Leu Glu Pro 
 145                150                155                160
Gly Pro Pro Lys Pro Gly Val Pro Gln Glu Pro Gly Arg Gly Gln Pro 
                 165                170                175
Asp Ala Val Pro Glu Pro Pro Pro Val Gly Trp Gln Cys Pro Gly Cys 
             180                185                190
Thr Phe Ile Asn Lys Pro Thr Arg Pro Gly Cys Glu Met Cys Cys Arg 
         195                200                205
Ala Arg Pro Glu Ala Tyr Gln Val Pro Ala Ser Tyr Gln Pro Asp Glu 
     210                215                220
Glu Glu Arg Ala Arg Leu Ala Gly Glu Glu Glu Ala Leu Arg Gln Tyr 
 225                230                235                240
Gln Gln Arg Lys Gln Gln Gln Gln Glu Gly Asn Tyr Leu Gln His Val 
                 245                250                255
Gln Leu Asp Gln Arg Ser Leu Val Leu Asn Thr Glu Pro Ala Glu Cys 
             260                265                270
Pro Val Cys Tyr Ser Val Leu Ala Pro Gly Glu Ala Val Val Leu Arg 
         275                280                285
Glu Cys Leu His Thr Phe Cys Arg Glu Cys Leu Gln Gly Thr Ile Arg 
     290                295                300
Asn Ser Gln Glu Ala Glu Val Ser Cys Pro Phe Ile Asp Asn Thr Tyr 
 305                310                315                320
Ser Cys Ser Gly Lys Leu Leu Glu Arg Glu Ile Lys Ala Leu Leu Thr 
                 325                330                335
Pro Glu Asp Tyr Gln Arg Phe Leu Asp Leu Gly Ile Ser Ile Ala Glu 
             340                345                350
Asn Arg Ser Ala Phe Ser Tyr His Cys Lys Thr Pro Asp Cys Lys Gly 
         355                360                365
Trp Cys Phe Phe Glu Asp Asp Val Asn Glu Phe Thr Cys Pro Val Cys 
     370                375                380
Phe His Val Asn Cys Leu Leu Cys Lys Ala Ile His Glu Gln Met Asn 
 385                390                395                400
Cys Lys Glu Tyr Gln Glu Asp Leu Ala Leu Arg Ala Gln Asn Asp Val 
                 405                410                415
Ala Ala Arg Gln Thr Thr Glu Met Leu Lys Val Met Leu Gln Gln Gly 
             420                425                430
Glu Ala Met Arg Cys Pro Gln Cys Gln Ile Val Val Gln Lys Lys Asp 
         435                440                445
Gly Cys Asp Trp Ile Arg Cys Thr Val Cys His Thr Glu Ile Cys Trp 
     450                455                460
Val Thr Lys Gly Pro Arg Trp Gly Pro Gly Gly Pro Gly Asp Thr Ser 
 465                470                475                480
Gly Gly Cys Arg Cys Arg Val Asn Gly Ile Pro Cys His Pro Ser Cys 
                 485                490                495
Gln Asn Cys His 
             500



<210> 207
<211> 11868
<212> DNA
<213> Rattus norvegicus
<308> AB011528
<400> 207

agcaaacca  ccgagcggc  gggagccat  ttggagcgt  gggaggcgg  agcggcgcc  60
ggaatgctg  ggtgggggc  gcaaaagcc  gggccgtat  ccaaacggg  tctggccgc  120
gagtagatg  tgcccagag  gcagtggcg  cgcggaccg  cgggcagag  ggccgaggg  180
cggggcggt  gcaggggcc  aggaggggg  cagagcagc  gggcgggcc  aaggcccgg  240
cccgggcgg  gggcggcgg  ggccgtgac  ggaggcggg  gtgatggcg  ggcggcctc  300
atggtgggg  ctcccggga  cgtcgaccc  gttactact  ctccttctc  tctctttgt  360
cccgtctag  cgggaggag  tggggggcg  tggggatca  ggctgggac  caggggtag  420
tactgctac  gggccaaga  ctcaaatcg  cagtggagc  gtagctctt  gtcccgagt  480
tccaggcgt  tgggaagat  gagatcctg  cctgggggt  agggaacct  tcttcatga  540
gctccgagt  ggtaggcaa  acgcccgga  tggtcgagg  gcccctgag  aaccaaacc  600
ggagccggt  gtccaggca  taggtagtc  cgagcaaga  gcaggtcag  gttcgggat  660
tttgttatg  tggcaccca  agatctcct  ttgtgggcg  acagggcat  tacgaagag  720
tagtttgcc  ctagatgct  tgtccccag  ggattctga  ctgaggaac  gctctcctc  780
cccttcgga  cttctggct  agcctgata  ccccaggcc  gtggccttc  aacgtaatg  840
taggagaag  atccgcaaa  gagtggaaa  ctttcgctg  tgcgggaaa  tatgggagc  900
aggacacaa  ggtcagggt  agagatccg  gacttccac  gtggatagg  gaccccttc  960
gcgggactg  ctccccggc  ctttgggat  tggcctggg  gaggattca  caccacgtg  1020
tgtgaggac  gctcctgcg  cgggttcag  acctcacga  tctcggaca  ctcccgagc  1080
catgcgctc  cgcggtctc  tccgccgcg  tttcctctt  gagcgccct  ggccgcgcc  1140
tcccggatt  ccgactggt  ctgaagcca  gcgaatact  tcaacgaac  aggctcgtt  1200
ccgtcgtgc  gcaaaccgc  acccgcagt  tcctcaata  aactaccaa  cacttgtac  1260
tgaaaatga  gcagcgggc  cagctgtgc  gcgcgtggt  gcgcaagac  cggacccag  1320
cgaagccgg  cgcctcgtc  actcgctgg  ggcgctcat  aacagtcgc  cgctggagc  1380
tttcagcat  gatcctcag  gtggcctca  acgcacggc  gccgctctg  accgtgaga  1440
tatggaacg  cactacctt  gagtgactg  acaggacca  ggctcaccg  gcctctcag  1500
taccaccat  gtggcggtg  cagtagctg  ccgcaacga  cacgcgcca  tgtttgagc  1560
agcccagta  cgggaaaca  ttcgtgaga  tgtggaaga  ggctacccc  tcctgcagt  1620
gcgtgccac  gacggtgac  cgccaccta  tgccaacct  cgctaccgc  tcgtggggt  1680
gccagctgc  cgtaccgca  cggccgctg  tttcgagat  gatccacgg  ccggcctta  1740
cagcactag  ggccgcgtg  accgggaac  catggaaag  tatgagctg  tggtagagg  1800
tagtgacca  ggtcaggag  ctgggccac  ttcagccac  gtacgagtg  acataactg  1860
gctggatga  aatgataac  ctccccagt  cagcgagaa  cgctatgtg  ctcaggtgc  1920
tgaggatgt  cgccctcac  cggtggtgc  acgtgtcac  gccacggac  aggacaagg  1980
tgccaatgg  ttggtacat  ataacatca  cagcggcaa  agccggggc  attttgcca  2040
cgatagtct  acgggtgag  tacaggtaa  ggcacctct  gactttgag  cagagagag  2100
atacgcttt  cgtatccgg  cacaagatg  aggccggcc  ccactgtcc  acaacacag  2160
cctggcaag  atccaggtg  tagacatca  tgatcatag  cctatcttt  tcagcacac  2220
ctttcaggt  tctgttttg  aaaatgcac  cctgggtca  tcagtcatt  acattcagg  2280
agtggacgc  gatcatggg  agaactcca  gttagagta  tctttaact  gcgtggcat  2340
agacacacc  tttgtgata  atagtgcca  tggctgggt  tctgtgagt  gtcccctgg  2400
ccgtgaatc  gtggaacat  acttctttg  ggtggaggc  cgagaccat  gttcacccc  2460
actctctgc  tcagccagt  tcacagtaa  tgtgttgga  gtcaacgac  atcggcctg  2520
gttcaccat  aaagagtac  accttcggc  caacgagga  gcagcggtg  gcaccagcg  2580
ggtcagtgt  actgcggta  atcgagatg  caacagtgc  atcagctac  aaatcacag  2640
tggcaacac  cggaaccga  tcgccatca  cacccaagg  ggcatgggt  tagtgaccc  2700
ggctctgcc  ctggattac  agcaggaac  ctacttcaa  ctggtgctg  ctgcatctg  2760
ccgtgccct  cacgaccac  gctatgtgc  tatcaacat  acagatgcc  acacacaca  2820
gcctgtctt  caaagcgct  actactcag  gagcatgaa  gaagaccgc  cagtgggta  2880
caccgtggt  gtcatcagt  cttctgatg  tgacgtggg  gaaaacgcc  gtatcacct  2940
ccttctgga  gacaacctg  cccagttcc  aatcgatgc  gactcaggg  ccattacac  3000
acaagctcc  ctggactat  aggaccaag  gacctatac  ctggccatt  ctgctcggg  3060
caacggtat  ccacagaag  cagatacca  atatgtgga  gttatggta  acgacgtga  3120
tgacaatgc  ccccagttt  tggcctccc  ctatacagg  ttggtctct  aagatgctc  3180
acctttcac  agtgttctg  agatctcag  cactgaccg  gatgctcat  ccaatggcc  3240
ggtccaata  actttccag  atggggaag  tggggatgg  gattttacc  ttgagccca  3300
ctctggcat  gtcaggact  tgaggcgac  ggaccggga  gcggtgcca  tgtatgagc  3360
gactgccta  gcagtggac  gtggcgtgc  cccactgag  actccagtc  gcatccagg  3420
gactgtaca  gacgtgaat  acaatgcac  tgtcttccc  gctgaggag  ttgaagtga  3480
ggtgaagga  aacagcatt  tggggtcgg  ggtggctca  atcaccgca  tggaccctg  3540
tgatggccc  aatgctcat  ttatgtacc  gatcgtgga  gggaacatc  ccgagctgt  3600
ccaaatgga  atcttctct  gagaactca  agcactcat  gacctggat  atgaggctc  3660
tcaggaata  gtgattgtg  tgcaggcca  atctgctcc  ctagttagc  gggccaccg  3720
gcatgtacg  ctggtcgac  agaacgata  cagtcctgt  ctcaacaac  tccagatcc  3780
ctttaacaa  tatgtatcc  accgatctg  cactttccc  tccggcatc  tcgggcgaa  3840
cccagctta  gacccggat  tctctgacc  cctctttta  tcctttgag  ggggcaatg  3900
actgcagct  ttagtggtc  accaaacca  tggggagct  cgactcagc  gaaagttag  3960
caacaatcg  ccactagtg  cgtccatgt  ggtaacagt  acagatggc  tgcatagtg  4020
tacagccca  tgtgttctg  gtgtggtca  catcacaga  gagttgctg  ccaacagct  4080
gactgttcg  ctggagaac  tgtggcaag  gcgtttcct  tcaccgctg  tgggtcatt  4140
tcttgaagg  gtggctgca  tgctcgcaa  acctaccga  gacgttttc  tcttcaaca  4200
ccagaacga  acggatgtg  ggggcaccg  gctcaacgt  agcttctca  cgctggcac  4260
tcgtggggc  ggggcaggc  ctgcagggc  ctggttcag  tccgaagag  tacaggagc  4320
actgtatgt  cgccgtgcc  ccttggcgg  ccgctcgct  ctcgacgtg  taccctttg  4380
cgacaacgt  tgcctgcgc  agccgtgcg  gaactacat  aaatgcgtg  cagtcctcc  4440
ctttgactc  tccgcgccc  ttctggcct  agcctccac  ctcttccga  ccatccaac  4500
catcgcggg  ctgcgctgc  gctgtccgc  tggcttcac  ggagacttc  gcgagacag  4560
gctcgacct  tgctactcg  acccttgtc  caatggcgg  gcgtgcgcg  ggcgcgagg  4620
aggctacac  tgcgtgtgc  gcccgcgct  caccgggga  gactgcgag  tggacactg  4680
agctggacg  tgtgtgccc  gtgtctgcc  caacggggg  acctgcacc  acgcaccca  4740
tggcggctt  cgttgccag  gccccgcgg  cggcgcttt  gagggcccg  gctgtgagg  4800
ggccgcacg  tcctttcct  ccagttcct  cgtcatgtt  cgcggtctg  gacagcgct  4860
ccacctcac  ctgtccctc  cgtttgcaa  tgtgcaacc  agcgggcta  tcttctaca  4920
cgggcgcct  aatgagaag  atgactttt  ggctctaga  cttgtagct  gtcaagtac  4980
gcttacata  tccacgggt  aatccagca  agtggtcag  cccacagtg  caggaggct  5040
gagtgacgg  cagtggcat  cagtgcatc  gagatacta  aacaagccc  ggacagatg  5100
gctaggggg  gctcagggc  cttcgaagg  caaggtggc  gtgttgagt  tggatgact  5160
caacgtggc  gtggctctg  ggtttggtg  tgagatcgg  aactactcg  gtgcagctg  5220
tggtgtgca  acaagctcc  agaagtccc  ggacctgac  ggccctctg  ttttggggg  5280
tgtccccaa  cttcccgag  acttccctg  gtcccgcaa  gacttcatc  gctgcatgc  5340
agacttgca  attgatggc  gccgagtgg  catggcagc  tttgtcgcc  acaatggca  5400
tacagcagg  tgtcaggcc  agtcacact  ttgtgcctc  ggcccctgc  agaacggtg  5460
cctctgctc  gagcgctgg  gcggcttca  ctgtgattg  cctgtgggc  ttggtggca  5520
agattgtcg  ctcacaatg  cccatccct  ccatttcca  ggcaacggg  ccctgagtt  5580
ggactttgg  aatgacatg  ctgtgtctg  gccatggta  ctgggacta  cgtttcgaa  5640
acgggcaac  aaaggggtc  tgatgcaag  gcagcttgg  ccacatagt  tgctcctct  5700
caagctaga  caagggttg  tgtctgtga  actcagtag  gcctcgggc  acgctgtcc  5760
cctcttgct  gaccagatg  ctgtcagcg  tggccggtg  catgacctt  ggctggagc  5820
gcaggagga  ccaggtggc  gaaggggcc  ccatatctt  atggtttca  tggacttca  5880
cctcttcca  gacaccatg  ccatgggga  tgagctgga  ggcctgaaa  taaagcatc  5940
ccacgtggg  ggcccgccc  ccagcagta  ggaggaggg  cctcagggt  tggttggct  6000
tattcaggg  gtgtggact  gctttactc  ctttgggtc  tcagccctg  cacctccca  6060
ccacagaat  aatgtggag  ctggctgca  tgtgaccaa  ccctgtgca  ctgggccct  6120
tcctcctca  gctaactgc  aagacctct  gcagacctt  tcctgtacc  gttggccag  6180
ttactacgg  ccaggctgt  tggatgcct  cctcctgaa  ccttgtcaa  accaggggt  6240
gtgccggca  ctccaagga  gcccccacg  ctatacctg  gactgtgca  gtggctatt  6300
tggtcagca  tgtgagcac  gaatggatc  gcagtgccc  cggggatgg  ggggaagcc  6360
aacctgtgg  ccctgcaac  gtgatgtcc  caagggctt  gaccccaac  gcaacaaga  6420
aagtggcca  tgccactgc  aggagttcc  ctatcgacc  aggggcagt  actcatgcc  6480
cccatgtga  tgctaccct  tgggctcca  ctcccgctc  tgtgcaccc  acagcgggc  6540
gtgcccctg  cgcccagga  cccttggcc  tcagtgtaa  agctgtgat  gcccctttg  6600
agaggtgac  gccagtggt  gccgagtac  ctacgatgc  tgccccaag  ccctgagat  6660
tggtgtgtg  tggccccag  ctaagtttg  tgttttggc  acagtaccc  gtccccggg  6720
ggccttggg  ttgcggggt  caggtgctg  ggtgcggct  tgtgatgaa  accacggtt  6780
gctggagcc  gacttcttc  actgtacct  tcctgcctt  cgagagctt  gtctgctgt  6840
ggatggcct  gagctgaac  agacggcac  ggatactgt  gaggccaag  agcttgctc  6900
gaggctgcg  gaggtgacc  gccagactg  ccactactt  agccaagat  tccgagtca  6960
tgcccgctt  ttggcctac  tgctggctt  cgagagcca  cagcagggc  tcgggctga  7020
agccacaca  gatgcccac  tcaatgaga  ccttctatg  gctggttct  cactgctgg  7080
tccagagac  ggagacttg  gggcagccc  ggggcagcg  gcccctggg  gctccccgg  7140
tagtgcagg  ctggtgcgg  atctggagg  atatgcagc  acacttgca  ggaacatgg  7200
cctgacata  ctgaatcct  tcggactag  cacacccaa  atcatgctc  gcattgacc  7260
tatggagca  cctagttca  cccagggag  ccaccgtta  ccccgctac  acagcaacc  7320
tttccgggg  caggacgcc  gggatcctc  tactcatgt  ctactgcct  cccagtccc  7380
acagccatc  ccttctgaa  ttctgccca  aagcagcaa  gcagaaaac  ccacagcct  7440
cggtgtggt  tccccacct  cccctctgg  gcctgagtc  gagcctggg  tctccatag  7500
cattctact  gtgtatcga  ccttgggag  gcttctccc  gcccagttc  aagctgagc  7560
ccggggcgc  aggcttccc  agaaccctg  tatgaactc  ccggtggtc  gcgtggctg  7620
ttttcgtgg  cgcaacttc  tcagaggtg  cctagtgtc  ccaatcaac  ttgagttcc  7680
cctactaca  acagcgaat  ggagcaagg  gatctgtgt  cagtgggac  cacctggcc  7740
ggcagacca  catgggatg  ggacggcaa  ggactgtga  ctggtacac  ggaatggct  7800
ccatgcacg  tgtcgctgt  gccggacgg  cactttcgg  gtccttatg  atgcctctc  7860
ccgtgagcg  ctagaggga  acctagagc  gctggcggt  ttcactcat  tggtcgtgg  7920
ggcgtctgt  actgcgcta  ttctgaccg  agctgtcct  ctgagcctg  gcagcctca  7980
gtccaacgt  cgtgggatc  atgccaatg  ggcagctgc  ctgggagtg  cagagcttc  8040
cttcctgct  ggaatccac  ggacccaca  ccagctgct  tgcacagtg  tcgccatcc  8100
cctacatta  ttcttcctc  gcaccttcg  gtggctcct  gtgcagggc  tgcacctct  8160
ccgaatgca  gttgagcct  gaaatgtgg  tcgtggcgc  atgcgcttc  accatgccc  8220
gggctgggg  gtccctgct  tgttgttgg  ccttgctgt  gggctggac  cggagggct  8280
tgggaaccc  gacttctgc  ggatctcca  ccacgaacc  cttatctgg  gttttgccg  8340
tcctatagt  cttgttatt  tgatgaatg  aatcatgtt  ctcctcgcg  cccgcacat  8400
ctgctccac  gggcagagg  aggccaaga  gacctctgt  ctcaggacc  ttcgcagct  8460
ttttctgct  cttctgctg  tcagtgcct  ctggctctt  ggccttctg  cagtcaacc  8520
cagcgtact  gccttccac  acctccatg  tggactctg  ggcctccag  gcctggctg  8580
gctgctgct  ttctgtgtc  tgaatgcag  tgctcgggc  gcctggacg  cagcctgtc  8640
aggcaagaa  gcagctccc  aggaaacaa  gccagcacc  gggccgggg  ctggggcct  8700
taacaacac  gccctcttt  aggagagtg  ccttatccg  atcactctt  gtgcctcca  8760
cgtctcttc  gtgagcagt  cccgctcag  cagggccca  gaccaggac  gccagcggg  8820
ccgcagcta  ctcagggac  atgttctgg  tcgacacgg  tcgaccgct  agcacgctg  8880
gcacagcct  caggctcat  ccggcccca  tgacctgga  gtggctatg  tccatcgag  8940
cgctggtgc  gactctgac  ctgacagcg  cctgtcctt  gaggaggag  ggagcctat  9000
catcccatc  tcagagagc  aggacaatg  ccggactcg  gggcgtttc  aacgtccac  9060
ccgcagggc  gcccagagt  agaggctcc  tgcccaccc  aaagatgtg  acggcaatg  9120
cctactgtc  tactggcca  ccctggggg  gtgtgaggc  gcaccgtgc  ctctgcagg  9180
gtggggctc  gaaaggcgc  tcggactag  cagcaacaa  gacgcagcc  acaacaacc  9240
gcctgaact  gccttgacc  gtggagatg  aacctccct  ggccgggca  agcggcaga  9300
gaaaggcat  ctgaagaac  ggttgcagt  cccactggt  cctcagact  gaggcactc  9360
tgagctgtc  tggtgccgt  cagctacct  gggccaccg  gctgtgccg  ctgcctcct  9420
tggccgcat  tatgcaggt  ggggtacag  tagtctttc  cagccggcc  gccgctact  9480
ttctcgaga  cagctggac  tgctcttaa  gcgacagct  agtagggag  gactagaag  9540
ggtcccagt  cctgcacct  ttttgcacc  cctgagccg  ccaggctcc  aggaacgcc  9600
ggatactgc  ccagcccgc  tggaacccc  agatagggg  agcacacta  cacggagac  9660
gccccctcg  gactaccct  gaaccatgg  tggccgctt  gggtcacgg  atgcgctgg  9720
cttaggggc  ccccgagaa  ggttgagca  acttccccc  ccccgacgc  accgggacc  9780
tgacccaca  cacccacct  tgcccctgt  tccacagag  ccactctca  gggaccccc  9840
cttgccatc  aggcccctg  actctctat  taggatctc  aactctcgg  agcggctgg  9900
ccaagtgcc  agtcgacac  cctcccggg  ggcccttgg  ccagcccca  agcttctca  9960
agccaggga  gacccagcc  gcggcccta  ccatggtcc  tccacagag  aactggaca  10020
tctgtcctc  atccttgcc  ctttcaact  ctcagccct  tcttctgtg  agtcctcga  10080
cacaccctc  ggccctcac  ccactgcca  gccttccgc  acagcctct  cacttggac  10140
ttccacacc  cgctcagcc  catctcata  catctcgga  ttgtcacct  attcagaag  10200
tcccagaag  gagggtcac  cctgagggg  gaccagcaa  tgagaagcc  ccaaggggc  10260
gcggaggat  tgggctgac  gaagagact  caggactga  cccaaggca  ccttcctca  10320
gccctcccc  cagttcagt  cagtgaaat  tggaggtcc  tcctgtgcg  atctgtgag  10380
atgcgtgtg  caggtgcag  ggtgggggc  gagggagga  ttttataca  tttgtaact  10440
tgtaaccag  gagatatgc  tatgttatt  ttcagcttt  ccttctccc  ggggtcttg  10500
gactgggct  ggggcgggg  agaggatgg  agagagatg  attttggcc  cctttgggt  10560
cttagcaaa  catcatctc  tttctttca  ctctcggta  agtggacca  tccggccga  10620
ccactcttt  ccctcctct  cccccacac  gatctgaac  tttttgggg  ccagagtgc  10680
aatttggtc  ttgcatttt  tccgatgcc  caagggcca  actcctatt  gggggttgg  10740
cctggaaac  ggggccctc  ctcctcctc  tgggggctc  tgtgctcca  tcctccctg  10800
gggtgtgga  atgtattac  tggagtccc  gccgcttac  gccttaaga  ctaggactg  10860
tgctgcggg  gctggtgga  cagcagaag  cttgtttac  gatcaaggc  tccctttct  10920
cctctggga  ggacttggg  ctctaatca  acattccta  agcgggtgg  tggagggta  10980
actcctttc  ttgtccctc  ttcactagt  tgtggtgcc  ttgattcat  atactgtcc  11040
cttgagggc  ggggggggg  cagttagca  agggagcgg  aactaggga  cccaagacc  11100
agaatgtag  tgccacagt  tcccactgt  tacaggatc  tccctggca  caggctgca  11160
cagtggctg  cccaccttc  gttagtccc  tataaaggg  aaaatgacg  ttaggatcc  11220
gttcacaaa  ctctccttt  ttatttgtc  gatgtccag  tctggggac  ttaaatttt  11280
ttactttgt  tacaggcca  gattatttt  taaaatggt  gggttttat  tattgttta  11340
agcttaaaa  attgactta  acactttgt  tacagttca  aatgtttcc  cctctttgt  11400
tacaagtga  aggtagaaa  agtggggga  gggcctaaa  gacccacct  tgatgcccc  11460
cacctggcc  tcttgaggt  ggcttctaa  cccaacttt  cccaggtca  aggtcagcc  11520
agtcttcta  cagcttgcc  caaaggtgg  tcaggactg  ggttctgtg  aaacaccac  11580
cacccctac  ctgtgcata  tcttgggag  cagtgtctg  gattcaaat  ttcacttca  11640
tgtctgtgc  aaatcccac  agccaggtt  cccagctct  tttacccag  ctgaccccc  11700
cccttgaag  gctgagagg  ctgtccgtg  ggagagtgt  cttgctaac  aagtcctag  11760
ttctgtaga  gcccatctc  ggggtcccc  tccaacagt  gccctcttc  ctgtctgtg  11820
aaattgttc  gtgaagccg  gctctgttt  gggaataaa  ttctatag  11868



<210> 208
<211> 3313
<212> PRT
<213> Rattus norvegicus
<308> BAA32459
<400> 208

Met Ala Arg Arg Pro Leu Trp Trp Gly Leu Pro Gly Pro Ser Thr Pro 
  1               5                  10                  15
Leu Leu Leu Leu Leu Leu Phe Ser Leu Phe Pro Ser Ser Arg Glu Glu 
             20                  25                  30
Met Gly Gly Gly Gly Asp Gln Gly Trp Asp Pro Gly Val Ala Thr Ala 
         35                  40                  45
Thr Gly Pro Arg Ala Gln Ile Gly Ser Gly Ala Val Ala Leu Cys Pro 
     50                  55                  60
Glu Ser Pro Gly Val Trp Glu Asp Gly Asp Pro Gly Leu Gly Val Arg 
 65                  70                  75                  80
Glu Pro Val Phe Met Lys Leu Arg Val Gly Arg Gln Asn Ala Arg Asn 
                 85                  90                  95
Gly Arg Gly Ala Pro Glu Gln Pro Asn Arg Glu Pro Val Val Gln Ala 
             100                105                110
Leu Gly Ser Arg Glu Gln Glu Ala Gly Gln Gly Ser Gly Tyr Leu Leu 
         115                120                125
Cys Trp His Pro Glu Ile Ser Ser Cys Gly Arg Thr Gly His Leu Arg 
     130                135                140
Arg Gly Ser Leu Pro Leu Asp Ala Leu Ser Pro Gly Asp Ser Asp Leu 
 145                150                155                160
Arg Asn Ser Ser Pro His Pro Ser Glu Leu Leu Ala Gln Pro Asp Ser 
                 165                170                175
Pro Arg Pro Val Ala Phe Gln Arg Asn Gly Arg Arg Ser Ile Arg Lys 
             180                185                190
Arg Val Glu Thr Phe Arg Cys Cys Gly Lys Leu Trp Glu Pro Gly His 
         195                200                205
Lys Gly Gln Gly Glu Arg Ser Ala Thr Ser Thr Val Asp Arg Gly Pro 
     210                215                220
Leu Arg Arg Asp Cys Leu Pro Gly Ser Leu Gly Ser Gly Leu Gly Glu 
 225                230                235                240
Asp Ser Ala Pro Arg Ala Val Arg Thr Ala Pro Ala Pro Gly Ser Ala 
                 245                250                255
Pro His Glu Ser Arg Thr Ala Pro Glu Arg Met Arg Ser Arg Gly Leu 
             260                265                270
Phe Arg Arg Gly Phe Leu Phe Glu Arg Pro Gly Pro Arg Pro Pro Gly 
         275                280                285
Phe Pro Thr Gly Ala Glu Ala Lys Arg Ile Leu Ser Thr Asn Gln Ala 
     290                295                300
Arg Ser Arg Arg Ala Ala Asn Arg His Pro Gln Phe Pro Gln Tyr Asn 
 305                310                315                320
Tyr Gln Thr Leu Val Pro Glu Asn Glu Ala Ala Gly Thr Ala Val Leu 
                 325                330                335
Arg Val Val Ala Gln Asp Pro Asp Pro Gly Glu Ala Gly Arg Leu Val 
             340                345                350
Tyr Ser Leu Ala Ala Leu Met Asn Ser Arg Ser Leu Glu Leu Phe Ser 
         355                360                365
Ile Asp Pro Gln Ser Gly Leu Ile Arg Thr Ala Ala Ala Leu Asp Arg 
     370                375                380
Glu Ser Met Glu Arg His Tyr Leu Arg Val Thr Ala Gln Asp His Gly 
 385                390                395                400
Ser Pro Arg Leu Ser Ala Thr Thr Met Val Ala Val Thr Val Ala Asp 
                 405                410                415
Arg Asn Asp His Ala Pro Val Phe Glu Gln Ala Gln Tyr Arg Glu Thr 
             420                425                430
Leu Arg Glu Asn Val Glu Glu Gly Tyr Pro Ile Leu Gln Leu Arg Ala 
         435                440                445
Thr Asp Gly Asp Ala Pro Pro Asn Ala Asn Leu Arg Tyr Arg Phe Val 
     450                455                460
Gly Ser Pro Ala Ala Arg Thr Ala Ala Ala Ala Ala Phe Glu Ile Asp 
 465                470                475                480
Pro Arg Ser Gly Leu Ile Ser Thr Ser Gly Arg Val Asp Arg Glu His 
                 485                490                495
Met Glu Ser Tyr Glu Leu Val Val Glu Ala Ser Asp Gln Gly Gln Glu 
             500                505                510
Pro Gly Pro Arg Ser Ala Thr Val Arg Val His Ile Thr Val Leu Asp 
         515                520                525
Glu Asn Asp Asn Ala Pro Gln Phe Ser Glu Lys Arg Tyr Val Ala Gln 
     530                535                540
Val Arg Glu Asp Val Arg Pro His Thr Val Val Leu Arg Val Thr Ala 
 545                550                555                560
Thr Asp Lys Asp Lys Asp Ala Asn Gly Leu Val His Tyr Asn Ile Ile 
                 565                570                575
Ser Gly Asn Ser Arg Gly His Phe Ala Ile Asp Ser Leu Thr Gly Glu 
             580                585                590
Ile Gln Val Met Ala Pro Leu Asp Phe Glu Ala Glu Arg Glu Tyr Ala 
         595                600                605
Leu Arg Ile Arg Ala Gln Asp Ala Gly Arg Pro Pro Leu Ser Asn Asn 
     610                615                620
Thr Gly Leu Ala Ser Ile Gln Val Val Asp Ile Asn Asp His Ser Pro 
 625                630                635                640
Ile Phe Val Ser Thr Pro Phe Gln Val Ser Val Leu Glu Asn Ala Pro 
                 645                650                655
Leu Gly His Ser Val Ile His Ile Gln Ala Val Asp Ala Asp His Gly 
             660                665                670
Glu Asn Ser Arg Leu Glu Tyr Ser Leu Thr Gly Val Ala Ser Asp Thr 
         675                680                685
Pro Phe Val Ile Asn Ser Ala Thr Gly Trp Val Ser Val Ser Gly Pro 
     690                695                700
Leu Asp Arg Glu Ser Val Glu His Tyr Phe Phe Gly Val Glu Ala Arg 
 705                710                715                720
Asp His Gly Ser Pro Pro Leu Ser Ala Ser Ala Ser Val Thr Val Thr 
                 725                730                735
Val Leu Asp Val Asn Asp Asn Arg Pro Glu Phe Thr Met Lys Glu Tyr 
             740                745                750
His Leu Arg Leu Asn Glu Asp Ala Ala Val Gly Thr Ser Val Val Ser 
         755                760                765
Val Thr Ala Val Asp Arg Asp Ala Asn Ser Ala Ile Ser Tyr Gln Ile 
     770                775                780
Thr Gly Gly Asn Thr Arg Asn Arg Phe Ala Ile Ser Thr Gln Gly Gly 
 785                790                795                800
Met Gly Leu Val Thr Leu Ala Leu Pro Leu Asp Tyr Lys Gln Glu Arg 
                 805                810                815
Tyr Phe Lys Leu Val Leu Thr Ala Ser Asp Arg Ala Leu His Asp His 
             820                825                830
Cys Tyr Val His Ile Asn Ile Thr Asp Ala Asn Thr His Arg Pro Val 
         835                840                845
Phe Gln Ser Ala His Tyr Ser Val Ser Met Asn Glu Asp Arg Pro Val 
     850                855                860
Gly Ser Thr Val Val Val Ile Ser Ala Ser Asp Asp Asp Val Gly Glu 
 865                870                875                880
Asn Ala Arg Ile Thr Tyr Leu Leu Glu Asp Asn Leu Pro Gln Phe Arg 
                 885                890                895
Ile Asp Ala Asp Ser Gly Ala Ile Thr Leu Gln Ala Pro Leu Asp Tyr 
             900                905                910
Glu Asp Gln Val Thr Tyr Thr Leu Ala Ile Thr Ala Arg Asp Asn Gly 
         915                920                925
Ile Pro Gln Lys Ala Asp Thr Thr Tyr Val Glu Val Met Val Asn Asp 
     930                935                940
Val Asn Asp Asn Ala Pro Gln Phe Val Ala Ser His Tyr Thr Gly Leu 
 945                950                955                960
Val Ser Glu Asp Ala Pro Pro Phe Thr Ser Val Leu Gln Ile Ser Ala 
                 965                970                975
Thr Asp Arg Asp Ala His Ala Asn Gly Arg Val Gln Tyr Thr Phe Gln 
             980                985                990
Asn Gly Glu Asp Gly Asp Gly Asp Phe Thr Ile Glu Pro Thr Ser Gly 
         995                1000                1005
Ile Val Arg Thr Val Arg Arg Leu Asp Arg Glu Ala Val Pro Val Tyr 
     1010                1015                1020
Glu Leu Thr Ala Tyr Ala Val Asp Arg Gly Val Pro Pro Leu Arg Thr 
 1025                1030                1035                1040
Pro Val Ser Ile Gln Val Thr Val Gln Asp Val Asn Asp Asn Ala Pro 
                 1045                1050                1055
Val Phe Pro Ala Glu Glu Phe Glu Val Arg Val Lys Glu Asn Ser Ile 
             1060                1065                1070
Val Gly Ser Val Val Ala Gln Ile Thr Ala Val Asp Pro Asp Asp Gly 
         1075                1080                1085
Pro Asn Ala His Ile Met Tyr Gln Ile Val Glu Gly Asn Ile Pro Glu 
     1090                1095                1100
Leu Phe Gln Met Asp Ile Phe Ser Gly Glu Leu Thr Ala Leu Ile Asp 
 1105                1110                1115                1120
Leu Asp Tyr Glu Ala Arg Gln Glu Tyr Val Ile Val Val Gln Ala Thr 
                 1125                1130                1135
Ser Ala Pro Leu Val Ser Arg Ala Thr Val His Val Arg Leu Val Asp 
             1140                1145                1150
Gln Asn Asp Asn Ser Pro Val Leu Asn Asn Phe Gln Ile Leu Phe Asn 
         1155                1160                1165
Asn Tyr Val Ser Asn Arg Ser Asp Thr Phe Pro Ser Gly Ile Ile Gly 
     1170                1175                1180
Arg Ile Pro Ala Tyr Asp Pro Asp Val Ser Asp His Leu Phe Tyr Ser 
 1185                1190                1195                1200
Phe Glu Arg Gly Asn Glu Leu Gln Leu Leu Val Val Asn Gln Thr Ser 
                 1205                1210                1215
Gly Glu Leu Arg Leu Ser Arg Lys Leu Asp Asn Asn Arg Pro Leu Val 
             1220                1225                1230
Ala Ser Met Leu Val Thr Val Thr Asp Gly Leu His Ser Val Thr Ala 
         1235                1240                1245
Gln Cys Val Leu Arg Val Val Ile Ile Thr Glu Glu Leu Leu Ala Asn 
     1250                1255                1260
Ser Leu Thr Val Arg Leu Glu Asn Met Trp Gln Glu Arg Phe Leu Ser 
 1265                1270                1275                1280
Pro Leu Leu Gly His Phe Leu Glu Gly Val Ala Ala Val Leu Ala Thr 
                 1285                1290                1295
Pro Thr Glu Asp Val Phe Ile Phe Asn Ile Gln Asn Asp Thr Asp Val 
             1300                1305                1310
Gly Gly Thr Val Leu Asn Val Ser Phe Ser Ala Leu Ala Pro Arg Gly 
         1315                1320                1325
Ala Gly Ala Gly Ala Ala Gly Pro Trp Phe Ser Ser Glu Glu Leu Gln 
     1330                1335                1340
Glu Gln Leu Tyr Val Arg Arg Ala Ala Leu Ala Ala Arg Ser Leu Leu 
 1345                1350                1355                1360
Asp Val Leu Pro Phe Asp Asp Asn Val Cys Leu Arg Glu Pro Cys Glu 
                 1365                1370                1375
Asn Tyr Met Lys Cys Val Ser Val Leu Arg Phe Asp Ser Ser Ala Pro 
             1380                1385                1390
Phe Leu Ala Ser Ala Ser Thr Leu Phe Arg Pro Ile Gln Pro Ile Ala 
         1395                1400                1405
Gly Leu Arg Cys Arg Cys Pro Pro Gly Phe Thr Gly Asp Phe Cys Glu 
     1410                1415                1420
Thr Glu Leu Asp Leu Cys Tyr Ser Asn Pro Cys Arg Asn Gly Gly Ala 
 1425                1430                1435                1440
Cys Ala Arg Arg Glu Gly Gly Tyr Thr Cys Val Cys Arg Pro Arg Phe 
                 1445                1450                1455
Thr Gly Glu Asp Cys Glu Leu Asp Thr Glu Ala Gly Arg Cys Val Pro 
             1460                1465                1470
Gly Val Cys Arg Asn Gly Gly Thr Cys Thr Asn Ala Pro Asn Gly Gly 
         1475                1480                1485
Phe Arg Cys Gln Cys Pro Ala Gly Gly Ala Phe Glu Gly Pro Arg Cys 
     1490                1495                1500
Glu Val Ala Ala Arg Ser Phe Pro Pro Ser Ser Phe Val Met Phe Arg 
 1505                1510                1515                1520
Gly Leu Arg Gln Arg Phe His Leu Thr Leu Ser Leu Ser Phe Ala Thr 
                 1525                1530                1535
Val Gln Pro Ser Gly Leu Leu Phe Tyr Asn Gly Arg Leu Asn Glu Lys 
             1540                1545                1550
His Asp Phe Leu Ala Leu Glu Leu Val Ala Gly Gln Val Arg Leu Thr 
         1555                1560                1565
Tyr Ser Thr Gly Glu Ser Ser Thr Val Val Ser Pro Thr Val Pro Gly 
     1570                1575                1580
Gly Leu Ser Asp Gly Gln Trp His Thr Val His Leu Arg Tyr Tyr Asn 
 1585                1590                1595                1600
Lys Pro Arg Thr Asp Ala Leu Gly Gly Ala Gln Gly Pro Ser Lys Asp 
                 1605                1610                1615
Lys Val Ala Val Leu Ser Val Asp Asp Cys Asn Val Ala Val Ala Leu 
             1620                1625                1630
Arg Phe Gly Ala Glu Ile Gly Asn Tyr Ser Cys Ala Ala Ala Gly Val 
         1635                1640                1645
Gln Thr Ser Ser Lys Lys Ser Leu Asp Leu Thr Gly Pro Leu Leu Leu 
     1650                1655                1660
Gly Gly Val Pro Asn Leu Pro Glu Asn Phe Pro Val Ser Arg Lys Asp 
 1665                1670                1675                1680
Phe Ile Gly Cys Met Arg Asp Leu His Ile Asp Gly Arg Arg Val Asp 
                 1685                1690                1695
Met Ala Ala Phe Val Ala Asn Asn Gly Thr Thr Ala Gly Cys Gln Ala 
             1700                1705                1710
Lys Ser His Phe Cys Ala Ser Gly Pro Cys Lys Asn Gly Gly Leu Cys 
         1715                1720                1725
Ser Glu Arg Trp Gly Gly Phe Ser Cys Asp Cys Pro Val Gly Phe Gly 
     1730                1735                1740
Gly Lys Asp Cys Arg Leu Thr Met Ala His Pro Tyr His Phe Gln Gly 
 1745                1750                1755                1760
Asn Gly Thr Leu Ser Trp Asp Phe Gly Asn Asp Met Pro Val Ser Val 
                 1765                1770                1775
Pro Trp Tyr Leu Gly Leu Ser Phe Arg Thr Arg Ala Thr Lys Gly Val 
             1780                1785                1790
Leu Met Gln Val Gln Leu Gly Pro His Ser Val Leu Leu Cys Lys Leu 
         1795                1800                1805
Asp Gln Gly Leu Leu Ser Val Thr Leu Ser Arg Ala Ser Gly His Ala 
     1810                1815                1820
Val His Leu Leu Leu Asp Gln Met Thr Val Ser Asp Gly Arg Trp His 
 1825                1830                1835                1840
Asp Leu Arg Leu Glu Leu Gln Glu Glu Pro Gly Gly Arg Arg Gly His 
                 1845                1850                1855
His Ile Phe Met Val Ser Leu Asp Phe Thr Leu Phe Gln Asp Thr Met 
             1860                1865                1870
Ala Met Gly Ser Glu Leu Glu Gly Leu Lys Val Lys His Leu His Val 
         1875                1880                1885
Gly Gly Pro Pro Pro Ser Ser Lys Glu Glu Gly Pro Gln Gly Leu Val 
     1890                1895                1900
Gly Cys Ile Gln Gly Val Trp Thr Gly Phe Thr Pro Phe Gly Ser Ser 
 1905                1910                1915                1920
Ala Leu Pro Pro Pro Ser His Arg Ile Asn Val Glu Pro Gly Cys Thr 
                 1925                1930                1935
Val Thr Asn Pro Cys Ala Ser Gly Pro Cys Pro Pro His Ala Asn Cys 
             1940                1945                1950
Lys Asp Leu Trp Gln Thr Phe Ser Cys Thr Cys Trp Pro Gly Tyr Tyr 
         1955                1960                1965
Gly Pro Gly Cys Val Asp Ala Cys Leu Leu Asn Pro Cys Gln Asn Gln 
     1970                1975                1980
Gly Ser Cys Arg His Leu Gln Gly Gly Pro His Gly Tyr Thr Cys Asp 
 1985                1990                1995                2000
Cys Ala Ser Gly Tyr Phe Gly Gln His Cys Glu His Arg Met Asp Gln 
                 2005                2010                2015
Gln Cys Pro Arg Gly Trp Trp Gly Ser Pro Thr Cys Gly Pro Cys Asn 
             2020                2025                2030
Cys Asp Val His Lys Gly Phe Asp Pro Asn Cys Asn Lys Thr Ser Gly 
         2035                2040                2045
Gln Cys His Cys Lys Glu Phe His Tyr Arg Pro Arg Gly Ser Asp Ser 
     2050                2055                2060
Cys Leu Pro Cys Asp Cys Tyr Pro Val Gly Ser Thr Ser Arg Ser Cys 
 2065                2070                2075                2080
Ala Pro His Ser Gly Gln Cys Pro Cys Arg Pro Gly Ala Leu Gly Arg 
                 2085                2090                2095
Gln Cys Asn Ser Cys Asp Ser Pro Phe Ala Glu Val Thr Ala Ser Gly 
             2100                2105                2110
Cys Arg Val Leu Tyr Asp Ala Cys Pro Lys Ser Leu Arg Ser Gly Val 
         2115                2120                2125
Trp Trp Pro Gln Thr Lys Phe Gly Val Leu Ala Thr Val Pro Cys Pro 
     2130                2135                2140
Arg Gly Ala Leu Gly Leu Arg Gly Thr Gly Ala Ala Val Arg Leu Cys 
 2145                2150                2155                2160
Asp Glu Asp His Gly Trp Leu Glu Pro Asp Phe Phe Asn Cys Thr Ser 
                 2165                2170                2175
Pro Ala Phe Arg Glu Leu Ser Leu Leu Leu Asp Gly Leu Glu Leu Asn 
             2180                2185                2190
Lys Thr Ala Leu Asp Thr Val Glu Ala Lys Lys Leu Ala Gln Arg Leu 
         2195                2200                2205
Arg Glu Val Thr Gly Gln Thr Asp His Tyr Phe Ser Gln Asp Val Arg 
     2210                2215                2220
Val Thr Ala Arg Leu Leu Ala Tyr Leu Leu Ala Phe Glu Ser His Gln 
 2225                2230                2235                2240
Gln Gly Phe Gly Leu Thr Ala Thr Gln Asp Ala His Phe Asn Glu Asn 
                 2245                2250                2255
Leu Leu Trp Ala Gly Ser Ala Leu Leu Ala Pro Glu Thr Gly Asp Leu 
             2260                2265                2270
Trp Ala Ala Leu Gly Gln Arg Ala Pro Gly Gly Ser Pro Gly Ser Ala 
         2275                2280                2285
Gly Leu Val Arg His Leu Glu Glu Tyr Ala Ala Thr Leu Ala Arg Asn 
     2290                2295                2300
Met Asp Leu Thr Tyr Leu Asn Pro Val Gly Leu Val Thr Pro Asn Ile 
 2305                2310                2315                2320
Met Leu Ser Ile Asp Arg Met Glu Gln Pro Ser Ser Ser Gln Gly Ala 
                 2325                2330                2335
His Arg Tyr Pro Arg Tyr His Ser Asn Leu Phe Arg Gly Gln Asp Ala 
             2340                2345                2350
Trp Asp Pro His Thr His Val Leu Leu Pro Ser Gln Ser Pro Gln Pro 
         2355                2360                2365
Ser Pro Ser Glu Val Leu Pro Thr Ser Ser Asn Ala Glu Asn Ala Thr 
     2370                2375                2380
Ala Ser Gly Val Val Ser Pro Pro Ala Pro Leu Glu Pro Glu Ser Glu 
 2385                2390                2395                2400
Pro Gly Ile Ser Ile Val Ile Leu Leu Val Tyr Arg Ala Leu Gly Gly 
                 2405                2410                2415
Leu Leu Pro Ala Gln Phe Gln Ala Glu Arg Arg Gly Ala Arg Leu Pro 
             2420                2425                2430
Gln Asn Pro Val Met Asn Ser Pro Val Val Ser Val Ala Val Phe Arg 
         2435                2440                2445
Gly Arg Asn Phe Leu Arg Gly Ala Leu Val Ser Pro Ile Asn Leu Glu 
     2450                2455                2460
Phe Arg Leu Leu Gln Thr Ala Asn Arg Ser Lys Ala Ile Cys Val Gln 
 2465                2470                2475                2480
Trp Asp Pro Pro Gly Pro Ala Asp Gln His Gly Met Trp Thr Ala Arg 
                 2485                2490                2495
Asp Cys Glu Leu Val His Arg Asn Gly Ser His Ala Arg Cys Arg Cys 
             2500                2505                2510
Ser Arg Thr Gly Thr Phe Gly Val Leu Met Asp Ala Ser Pro Arg Glu 
         2515                2520                2525
Arg Leu Glu Gly Asp Leu Glu Leu Leu Ala Val Phe Thr His Val Val 
     2530                2535                2540
Val Ala Ala Ser Val Thr Ala Leu Val Leu Thr Ala Ala Val Leu Leu 
 2545                2550                2555                2560
Ser Leu Arg Ser Leu Lys Ser Asn Val Arg Gly Ile His Ala Asn Val 
                 2565                2570                2575
Ala Ala Ala Leu Gly Val Ala Glu Leu Leu Phe Leu Leu Gly Ile His 
             2580                2585                2590
Arg Thr His Asn Gln Leu Leu Cys Thr Val Val Ala Ile Leu Leu His 
         2595                2600                2605
Tyr Phe Phe Leu Ser Thr Phe Ala Trp Leu Leu Val Gln Gly Leu His 
     2610                2615                2620
Leu Tyr Arg Met Gln Val Glu Pro Arg Asn Val Asp Arg Gly Ala Met 
 2625                2630                2635                2640
Arg Phe Tyr His Ala Leu Gly Trp Gly Val Pro Ala Val Leu Leu Gly 
                 2645                2650                2655
Leu Ala Val Gly Leu Asp Pro Glu Gly Tyr Gly Asn Pro Asp Phe Cys 
             2660                2665                2670
Trp Ile Ser Ile His Glu Pro Leu Ile Trp Ser Phe Ala Gly Pro Ile 
         2675                2680                2685
Val Leu Val Ile Val Met Asn Gly Ile Met Phe Leu Leu Ala Ala Arg 
     2690                2695                2700
Thr Ser Cys Ser Thr Gly Gln Arg Glu Ala Lys Lys Thr Ser Val Leu 
 2705                2710                2715                2720
Arg Thr Leu Arg Ser Ser Phe Leu Leu Leu Leu Leu Val Ser Ala Ser 
                 2725                2730                2735
Trp Leu Phe Gly Leu Leu Ala Val Asn His Ser Val Leu Ala Phe His 
             2740                2745                2750
Tyr Leu His Ala Gly Leu Cys Gly Leu Gln Gly Leu Ala Val Leu Leu 
         2755                2760                2765
Leu Phe Cys Val Leu Asn Ala Asp Ala Arg Ala Ala Trp Thr Pro Ala 
     2770                2775                2780
Cys Leu Gly Lys Lys Ala Ala Pro Glu Glu Thr Arg Pro Ala Pro Gly 
 2785                2790                2795                2800
Pro Gly Ser Gly Ala Tyr Asn Asn Thr Ala Leu Phe Glu Glu Ser Gly 
                 2805                2810                2815
Leu Ile Arg Ile Thr Leu Gly Ala Ser Thr Val Ser Ser Val Ser Ser 
             2820                2825                2830
Ala Arg Ser Gly Arg Ala Gln Asp Gln Asp Ser Gln Arg Gly Arg Ser 
         2835                2840                2845
Tyr Leu Arg Asp Asn Val Leu Val Arg His Gly Ser Thr Ala Glu His 
     2850                2855                2860
Ala Glu His Ser Leu Gln Ala His Ala Gly Pro Thr Asp Leu Asp Val 
 2865                2870                2875                2880
Ala Met Phe His Arg Asp Ala Gly Ala Asp Ser Asp Ser Asp Ser Asp 
                 2885                2890                2895
Leu Ser Leu Glu Glu Glu Arg Ser Leu Ser Ile Pro Ser Ser Glu Ser 
             2900                2905                2910
Glu Asp Asn Gly Arg Thr Arg Gly Arg Phe Gln Arg Pro Leu Arg Arg 
         2915                2920                2925
Ala Ala Gln Ser Glu Arg Leu Leu Ala His Pro Lys Asp Val Asp Gly 
     2930                2935                2940
Asn Asp Leu Leu Ser Tyr Trp Pro Ala Leu Gly Glu Cys Glu Ala Ala 
 2945                2950                2955                2960
Pro Cys Ala Leu Gln Ala Trp Gly Ser Glu Arg Arg Leu Gly Leu Asp 
                 2965                2970                2975
Ser Asn Lys Asp Ala Ala Asn Asn Asn Gln Pro Glu Leu Ala Leu Thr 
             2980                2985                2990
Ser Gly Asp Glu Thr Ser Leu Gly Arg Ala Gln Arg Gln Arg Lys Gly 
         2995                3000                3005
Ile Leu Lys Asn Arg Leu Gln Tyr Pro Leu Val Pro Gln Thr Arg Gly 
     3010                3015                3020
Thr Pro Glu Leu Ser Trp Cys Arg Ala Ala Thr Leu Gly His Arg Ala 
 3025                3030                3035                3040
Val Pro Ala Ala Ser Tyr Gly Arg Ile Tyr Ala Gly Gly Gly Thr Gly 
                 3045                3050                3055
Ser Leu Ser Gln Pro Ala Ser Arg Tyr Ser Ser Arg Glu Gln Leu Asp 
             3060                3065                3070
Leu Leu Leu Arg Arg Gln Leu Ser Arg Glu Arg Leu Glu Glu Val Pro 
         3075                3080                3085
Val Pro Ala Pro Val Leu His Pro Leu Ser Arg Pro Gly Ser Gln Glu 
     3090                3095                3100
Arg Leu Asp Thr Ala Pro Ala Arg Leu Glu Pro Arg Asp Arg Gly Ser 
 3105                3110                3115                3120
Thr Leu Pro Arg Arg Gln Pro Pro Arg Asp Tyr Pro Gly Thr Met Ala 
                 3125                3130                3135
Gly Arg Phe Gly Ser Arg Asp Ala Leu Asp Leu Gly Ala Pro Arg Glu 
             3140                3145                3150
Trp Leu Ser Thr Leu Pro Pro Pro Arg Arg Asn Arg Asp Leu Asp Pro 
         3155                3160                3165
Gln His Pro Pro Leu Pro Leu Ser Pro Gln Arg Pro Leu Ser Arg Asp 
     3170                3175                3180
Pro Leu Leu Pro Ser Arg Pro Leu Asp Ser Leu Ser Arg Ile Ser Asn 
 3185                3190                3195                3200
Ser Arg Glu Arg Leu Asp Gln Val Pro Ser Arg His Pro Ser Arg Glu 
                 3205                3210                3215
Ala Leu Gly Pro Ala Pro Gln Leu Leu Arg Ala Arg Glu Asp Pro Ala 
             3220                3225                3230
Ser Gly Pro Ser His Gly Pro Ser Thr Glu Gln Leu Asp Ile Leu Ser 
         3235                3240                3245
Ser Ile Leu Ala Ser Phe Asn Ser Ser Ala Leu Ser Ser Val Gln Ser 
     3250                3255                3260
Ser Ser Thr Pro Ser Gly Pro His Thr Thr Ala Thr Pro Ser Ala Thr 
 3265                3270                3275                3280
Ala Ser Ala Leu Gly Pro Ser Thr Pro Arg Ser Ala Thr Ser His Ser 
                 3285                3290                3295
Ile Ser Glu Leu Ser Pro Asp Ser Glu Val Pro Arg Ser Glu Gly His 
             3300                3305                3310
Ser 
         3315



<210> 209
<211> 5832
<212> DNA
<213> Homo sapiens
<308> AB011536
<400> 209

gccctgccc  cctcacgca  actgccggg  cctctggca  accttttct  gcacctgcc  60
gccaggtta  tacggccca  gctgtgtgg  tgcctgcct  ctgaacccc  gtcagaacc  120
gggatcatg  cggcacctg  caggagccc  ccatggcta  acctgtgac  gtgtgggtg  180
ctatttcgg  caccactgt  agcacagga  ggaccagca  tgcccacgg  gctggtggg  240
gagcccaac  tgtggcccc  gcaactgtg  tgttcacaa  ggttttgat  ccaactgca  300
caagacaaa  gggcagtgt  actgcaagg  gttccacta  cgaccgcgg  gcagtgact  360
ttgcctccc  tgtgactgc  accctgtgg  ctccacctc  cgctcatgt  caccccaca  420
cgggcagtg  ccctgtcgc  caggagccc  tggccgcca  tgcaacagc  gtgacagtc  480
cttcgcaga  gtgacagcc  gcggctgcc  ggtgctcta  gatgcctgc  ctaagtccc  540
gagatctgg  gtgtggtgg  cccagacaa  gtttggcgt  ctggccaca  tgccctgtc  600
ccggggggc  ctgggattg  ggggtgcag  tgctgctgt  cggctgtgt  atgaggccc  660
gggttggct  gagcccgac  tcttcaact  tacctcccc  gcctttcga  agctcagtc  720
gctgctgga  ggcctagag  tgaacaaga  ggcactgga  accatggag  ccaagaagc  780
ggctcagcg  ctacgggag  tgactggcc  cactgacca  tattttagc  aagatgttc  840
agtcactgc  cgcctgctg  cccacctgc  ggccttcga  agccatcag  agggcttcg  900
gctgacagc  acacaggat  cccacttca  tgagaatct  ctgtgggcc  gctctgcac  960
gcttgcccc  gagacaggg  acttgtggg  ggcgctggg  cagcgggcc  ctgggggct  1020
cccaggcag  gcgggactg  tgaggcacc  ggaggagta  gcagccaca  tcgcaagga  1080
tatggaact  acatacctg  atcccatgg  gctggtgac  cctaatatc  tgctcagca  1140
tgaccgcat  gagcacccc  gttctcccc  gggggcccg  cgctaccct  gctaccata  1200
caacctctt  cgaggccag  atgcctggg  tcctcacac  catgtgctg  tgccttccc  1260
gtccccacg  ccatcccca  ctgaagttc  gcccacaag  agcagcata  aaaactcca  1320
cacctcaag  gtggtcccc  caccagccc  gccagagcc  gagcctggg  tctccatta  1380
cattctcct  gtttaccgc  ccttagggg  actgctccc  gcccagttc  aggcagaac  1440
ccgaggtgc  aggcttcct  agaaccccg  catgaactc  ccggtggtc  gcgtggctg  1500
gttccacgg  cgcaacttc  taaggggaa  cctggagtc  cccatcagc  tagagtttc  1560
cctgctaca  acagcgaat  ggagcaagg  gatctgtgt  cagtgggac  cacctggcc  1620
ggcggagca  catggtgtg  ggacagcac  ggactgcga  ctggtgcac  ggaatgggt  1680
ccacgcacg  tgtcgctgc  gccggacag  gacctttgg  gtcctcatg  atgcctctc  1740
ccgtgagag  ctggagggc  acctggagc  gctggctgt  ttcacccac  tggtcgtgg  1800
tgtgtctgt  gctgcgctg  tgctgactg  agccatcct  ctgagcctg  gcagcctca  1860
gtccaatgt  cgtgggatc  atgccaatg  ggcagccgc  ctgggggtg  cagagctcc  1920
cttcctgct  gggattcac  ggacccaca  tcagctggt  tgcactgca  tcgccatcc  1980
cctgcacta  ttcttcctc  gcaccttcg  gtggctctt  gtgcagggg  tgcacctct  2040
ccgcatgca  gttgagcca  gcaacgtgg  ccgcggcgc  atgcgcttc  accatgccc  2100
gggctgggg  gtccctgct  tgctgctgg  ccttgctgt  ggcctggac  ctgagggct  2160
tgggaaccc  gacttctgc  ggatctcag  ccacgagcc  ctcatctgg  gctttgctg  2220
ccctgttgt  ctggtcata  tgatgaacg  gaccatgtt  ctcctcgct  cccgcacat  2280
ctgctccac  gggcagagg  aggccaaga  gacctctgc  ctgaccctt  gcagctcct  2340
cctgctgct  ctgctggtc  gtgcctcct  gctctttgg  ctcctggca  tcaaccaca  2400
catcctagc  ttccactac  tccatgctg  actctgcgg  ctccagggc  tggcggtgc  2460
gctgctctt  tgtgtccta  atgcagatg  tcgggctgc  tggatgcca  cctgtctgg  2520
caggaaggc  gcgcctgag  aggcaaggc  agcacctgg  ctgggacct  gggcctaca  2580
caacacggc  ctctttgag  agagtggcc  catccgcat  actctgggc  cctccaccg  2640
ctcctctgt  agcagtgcc  gctccggcc  gacccagga  caggacagc  agcggggcc  2700
cagctacct  agggacaat  tcctggttc  acatggctc  gccgctgac  acactgacc  2760
cagcctcca  gctcatgct  gccccactg  cctggacgt  gccatgttc  atcgagatg  2820
tggcgcaga  tccgactct  acagtgacc  gtccttgga  gaggagagg  gtctctcca  2880
tccatcttc  gaaagcgag  acaatggcc  gacgcgggg  cgcttccaa  ggccactct  2940
ccgagcagc  cagagtgag  ggctcctca  ccaccccaa  gatgtggat  gcaatgacc  3000
cctgtccta  tggccagcc  tgggggagt  cgaggcagc  ccctgtgct  tgcagactt  3060
gggctctga  aggcgcctg  ggctggaca  cagcaagga  gcagctaac  acaaccagc  3120
agacccggc  ctgaccagt  gggatgaga  ttctctggg  cgggcccag  gccagagga  3180
aggcatcct  aagaaccgg  tgcaatacc  actggtgcc  cagacccga  gtgcccctg  3240
gctgtcctg  tgccgtgca  ccaccttgg  ccaccgtgc  gtgccagct  cctcttacg  3300
tcgcatcta  gctggcggg  gcacgggca  cctttcaca  ccagccagc  gctactctt  3360
tagagaaca  ctggacctg  tcctccggc  gcaactgag  cgtgagcga  tagaggaag  3420
ccctgcccc  gttctacgt  ccctgagcc  gccagggtc  caggaatgc  tggatgctg  3480
accaggccg  ctggagccc  aagatcggg  cagcaccct  ccacggagg  agccacctc  3540
ggactaccc  ggcgccatg  ctggccgct  cgggtcacg  gatgcgctc  acttagggg  3600
acctcgaga  tggttgagc  cgctgcctc  gccccgccg  acccgggac  ttgacccac  3660
gcccccacc  ctgcccctg  ctccccagc  gcaactctc  agggacccc  tcttgccat  3720
ccggccgct  gactctctg  ctaggagct  gaactctcg  gagcagctg  accaggtgc  3780
tagccggca  ccctcacga  aagcccttg  gccactccc  cagctgctc  gagctaggg  3840
ggactcggt  agtggcccc  gccatggcc  ctccacaga  cagttggac  ttctttcct  3900
catccttgc  tctttcaac  cctcggccc  ctcctctgt  caatcttca  gcacaccct  3960
gggccctca  accactgcc  caccttctg  cacagcctc  gtgcttggg  cctccacgc  4020
acgttctgc  acgtctcac  gcatctcgg  gctgtcgcc  gactcagaa  ttcccagaa  4080
tgagggtca  tcctgaggg  atgacggcg  ggacgagga  cagctgagg  cgacagagg  4140
tctaggcta  caggagaga  tccaggagt  ggggcagat  ccaaggcag  ctcctgctc  4200
ccagtggtg  gtgccccag  tctacctgg  gtggcaggg  tgaggctcc  tgtgcatct  4260
tgagcatgc  tgtgacagg  gcagagacg  gggactgga  ggagacttt  atacgtttt  4320
tacctttgt  accagagag  tgcttatgt  atttttcag  ttttctgtc  cctgggggg  4380
ttgaggctg  gctgggagg  ggagggaga  agagggaga  atgcagttt  accccattt  4440
ggtcctgag  aaaccctat  ctcatctct  tctccttcc  ggggtggac  cagatgggt  4500
ggacacatg  cttcctccc  ctattccac  cccaagttg  tctgagtat  gtcaggggc  4560
caaagtaca  aattgttct  tgcttttta  tgaatgctc  aaaggccaa  cttctgggg  4620
tgggggttg  tcttggaaa  aggggtcct  tgacttcct  atgggggct  gctcatacc  4680
cccctcctg  tggatgtgt  tgtttatta  gtggagtcc  tgccactta  tgccttatg  4740
cctaggact  atgctgtgg  gtgctggtg  agcagctga  gtcgtgttt  cagagcaag  4800
cttccctgt  tcccacggg  aggggctcg  gcctctagt  agacattcc  gcagagggt  4860
ggtggaggg  tcattcacc  gcccctgca  caagcaaaa  ttgtctgtg  tgccatttg  4920
ttccctgac  ctgccccct  cttgaattg  ttccgaagg  tagggtggg  aggtgagca  4980
agggagcag  aacaaggga  ttcaagacc  agaatgtag  tgccactgc  tcctatgtt  5040
acaggatcc  ccgtggccc  aggcacctg  gctgcagga  gtgactccg  tccactcct  5100
ctttattcc  ttaaaaagg  aaaaatgac  gttacgacc  tgttcacaa  actcttact  5160
ttgctattt  gtctgctgt  cagaactga  gactttaaa  ttttgttac  gtttacaag  5220
ccagattca  aaaatgttt  tactttgtt  acaactcaa  actttgagt  ttacacttt  5280
tttacagta  ataattttt  ttcctttgt  tccaagtga  aggtaggga  agtgggaga  5340
ggacttgga  gacccacct  tgaggaccc  gacctggcc  tcttgaggg  ttttctaac  5400
cccaggtct  ccaggccga  ggtcagcct  gagtcccgt  taacagcag  tccagaaga  5460
cttgagagt  ggcgtcctc  aaccacggg  gagagtggc  gtgcagggc  ggggggtgg  5520
ctgtgcaga  acctcctca  ccaccaccc  atgcatact  ttgggaagc  gcttcctgg  5580
agattagaa  ttctacttc  ctgactgga  ctaaatccc  ccagccagg  cccaaactc  5640
ccttaccga  aaggacccc  gctcttgaa  ggctgagtg  cctgctggg  gtgggaggg  5700
gtctttact  tgtcctagg  ttcgtagat  cccctctct  gggttcccc  cctccagcc  5760
agcggccct  tttcctgtc  gtgtaaatt  ttccgtgaa  ccgcgctct  ttttgggaa  5820
aaacttcta  ag  5832



<210> 210
<211> 2923
<212> PRT
<213> Homo sapiens
<308> XP_042739
<400> 210

Met Arg Ser Pro Ala Thr Gly Val Pro Leu Pro Thr Pro Pro Pro Pro 
  1               5                  10                  15
Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Leu Leu Gly Asp 
             20                  25                  30
Gln Val Gly Pro Cys Arg Ser Leu Gly Ser Arg Gly Arg Gly Ser Ser 
         35                  40                  45
Gly Ala Cys Ala Pro Met Gly Trp Leu Cys Pro Ser Ser Ala Ser Asn 
     50                  55                  60
Leu Trp Leu Tyr Thr Ser Arg Cys Arg Asp Ala Gly Thr Glu Leu Thr 
 65                  70                  75                  80
Gly His Leu Val Pro His His Asp Gly Leu Arg Val Trp Cys Pro Glu 
                 85                  90                  95
Ser Glu Ala His Ile Pro Leu Pro Pro Ala Pro Glu Gly Cys Pro Trp 
             100                105                110
Ser Cys Arg Leu Leu Gly Ile Gly Gly His Leu Ser Pro Gln Gly Lys 
         115                120                125
Leu Thr Leu Pro Glu Glu His Pro Cys Leu Lys Ala Pro Arg Leu Arg 
     130                135                140
Cys Gln Ser Cys Lys Leu Ala Gln Ala Pro Gly Leu Arg Ala Gly Glu 
 145                150                155                160
Arg Ser Pro Glu Glu Ser Leu Gly Gly Arg Arg Lys Arg Asn Val Asn 
                 165                170                175
Thr Ala Pro Gln Phe Gln Pro Pro Ser Tyr Gln Ala Thr Val Pro Glu 
             180                185                190
Asn Gln Pro Ala Gly Thr Pro Val Ala Ser Leu Arg Ala Ile Asp Pro 
         195                200                205
Asp Glu Gly Glu Ala Gly Arg Leu Glu Tyr Thr Met Asp Ala Leu Phe 
     210                215                220
Asp Ser Arg Ser Asn Gln Phe Phe Ser Leu Asp Pro Val Thr Gly Ala 
 225                230                235                240
Val Thr Thr Ala Glu Glu Leu Asp Arg Glu Thr Lys Ser Thr His Val 
                 245                250                255
Phe Arg Val Thr Ala Gln Asp His Gly Met Pro Arg Arg Ser Ala Leu 
             260                265                270
Ala Thr Leu Thr Ile Leu Val Thr Asp Thr Asn Asp His Asp Pro Val 
         275                280                285
Phe Glu Gln Gln Glu Tyr Lys Glu Ser Leu Arg Glu Asn Leu Glu Val 
     290                295                300
Gly Tyr Glu Val Leu Thr Val Arg Ala Thr Asp Gly Asp Ala Pro Pro 
 305                310                315                320
Asn Ala Asn Ile Leu Tyr Arg Leu Leu Glu Gly Ser Gly Gly Ser Pro 
                 325                330                335
Ser Glu Val Phe Glu Ile Asp Pro Arg Ser Gly Val Ile Arg Thr Arg 
             340                345                350
Gly Pro Val Asp Arg Glu Glu Val Glu Ser Tyr Gln Leu Thr Val Glu 
         355                360                365
Ala Ser Asp Gln Gly Arg Asp Pro Gly Pro Arg Ser Thr Thr Ala Ala 
     370                375                380
Val Phe Leu Ser Val Glu Asp Asp Asn Asp Asn Ala Pro Gln Phe Ser 
 385                390                395                400
Glu Lys Arg Tyr Val Val Gln Val Arg Glu Asp Val Thr Pro Gly Ala 
                 405                410                415
Pro Val Leu Arg Val Thr Ala Ser Asp Arg Asp Lys Gly Ser Asn Ala 
             420                425                430
Val Val His Tyr Ser Ile Met Ser Gly Asn Ala Arg Gly Gln Phe Tyr 
         435                440                445
Leu Asp Ala Gln Thr Gly Ala Leu Asp Val Val Ser Pro Leu Asp Tyr 
     450                455                460
Glu Thr Thr Lys Glu Tyr Thr Leu Arg Val Arg Ala Gln Asp Gly Gly 
 465                470                475                480
Arg Pro Pro Leu Ser Asn Val Ser Gly Leu Val Thr Val Gln Val Leu 
                 485                490                495
Asp Ile Asn Asp Asn Ala Pro Ile Phe Val Ser Thr Pro Phe Gln Ala 
             500                505                510
Thr Val Leu Glu Ser Val Pro Leu Gly Tyr Leu Val Leu His Val Gln 
         515                520                525
Ala Ile Asp Ala Asp Ala Gly Asp Asn Ala Arg Leu Glu Tyr Arg Leu 
     530                535                540
Ala Gly Val Gly His Asp Phe Pro Phe Thr Ile Asn Asn Gly Thr Gly 
 545                550                555                560
Trp Ile Ser Val Ala Ala Glu Leu Asp Arg Glu Glu Val Asp Phe Tyr 
                 565                570                575
Ser Phe Gly Val Glu Ala Arg Asp His Gly Thr Pro Ala Leu Thr Ala 
             580                585                590
Ser Ala Ser Val Ser Val Thr Val Leu Asp Val Asn Asp Asn Asn Pro 
         595                600                605
Thr Phe Thr Gln Pro Glu Tyr Thr Val Arg Leu Asn Glu Asp Ala Ala 
     610                615                620
Val Gly Thr Ser Val Val Thr Val Ser Ala Val Asp Arg Asp Ala His 
 625                630                635                640
Ser Val Ile Thr Tyr Gln Ile Thr Ser Gly Asn Thr Arg Asn Arg Phe 
                 645                650                655
Ser Ile Thr Ser Gln Ser Gly Gly Gly Leu Val Ser Leu Ala Leu Pro 
             660                665                670
Leu Asp Tyr Lys Leu Glu Arg Gln Tyr Val Leu Ala Val Thr Ala Ser 
         675                680                685
Asp Gly Thr Arg Gln Asp Thr Ala Gln Ile Val Val Asn Val Thr Asp 
     690                695                700
Ala Asn Thr His Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Asn 
 705                710                715                720
Val Asn Glu Asp Arg Pro Ala Gly Thr Thr Val Val Leu Ile Ser Ala 
                 725                730                735
Thr Asp Glu Asp Thr Gly Glu Asn Ala Arg Ile Thr Tyr Phe Met Glu 
             740                745                750
Asp Ser Ile Pro Gln Phe Arg Ile Asp Ala Asp Thr Gly Ala Val Thr 
         755                760                765
Thr Gln Ala Glu Leu Asp Tyr Glu Asp Gln Val Ser Tyr Thr Leu Ala 
     770                775                780
Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Tyr 
 785                790                795                800
Leu Glu Ile Leu Val Asn Asp Val Asn Asp Asn Ala Pro Gln Phe Leu 
                 805                810                815
Arg Asp Ser Tyr Gln Gly Ser Val Tyr Glu Asp Val Pro Pro Phe Thr 
             820                825                830
Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ser Gly Leu Asn Gly 
         835                840                845
Arg Val Phe Tyr Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe 
     850                855                860
Ile Val Glu Ser Thr Ser Gly Ile Val Arg Thr Leu Arg Arg Leu Asp 
 865                870                875                880
Arg Glu Asn Val Ala Gln Tyr Val Leu Arg Ala Tyr Ala Val Asp Lys 
                 885                890                895
Gly Met Pro Pro Ala Arg Thr Pro Met Glu Val Thr Val Thr Val Leu 
             900                905                910
Asp Val Asn Asp Asn Pro Pro Val Phe Glu Gln Asp Glu Phe Asp Val 
         915                920                925
Phe Val Glu Glu Asn Ser Pro Ile Gly Leu Ala Val Ala Arg Val Thr 
     930                935                940
Ala Thr Asp Pro Asp Glu Gly Thr Asn Ala Gln Ile Met Tyr Gln Ile 
 945                950                955                960
Val Glu Gly Asn Ile Pro Glu Val Phe Gln Leu Asp Ile Phe Ser Gly 
                 965                970                975
Glu Leu Thr Ala Leu Val Asp Leu Asp Tyr Glu Asp Arg Pro Glu Tyr 
             980                985                990
Val Leu Val Ile Gln Ala Thr Ser Ala Pro Leu Val Ser Arg Ala Thr 
         995                1000                1005
Val His Val Arg Leu Leu Asp Arg Asn Asp Asn Pro Pro Val Leu Gly 
     1010                1015                1020
Asn Phe Glu Ile Leu Phe Asn Asn Tyr Val Thr Asn Arg Ser Ser Ser 
 1025                1030                1035                1040
Phe Pro Gly Gly Ala Ile Gly Arg Val Pro Ala His Asp Pro Asp Ile 
                 1045                1050                1055
Ser Asp Ser Leu Thr Tyr Ser Phe Glu Arg Gly Asn Glu Leu Ser Leu 
             1060                1065                1070
Val Leu Leu Asn Ala Ser Thr Gly Glu Leu Lys Leu Ser Arg Ala Leu 
         1075                1080                1085
Asp Asn Asn Arg Pro Leu Glu Ala Ile Met Ser Val Leu Val Ser Asp 
     1090                1095                1100
Gly Val His Ser Val Thr Ala Gln Cys Ala Leu Arg Val Thr Ile Ile 
 1105                1110                1115                1120
Thr Asp Glu Met Leu Thr His Ser Ile Thr Leu Arg Leu Glu Asp Met 
                 1125                1130                1135
Ser Pro Glu Arg Phe Leu Ser Pro Leu Leu Gly Leu Phe Ile Gln Ala 
             1140                1145                1150
Val Ala Ala Thr Leu Ala Thr Pro Pro Asp His Val Val Val Phe Asn 
         1155                1160                1165
Val Gln Arg Asp Thr Asp Ala Pro Gly Gly His Ile Leu Asn Val Ser 
     1170                1175                1180
Leu Ser Val Gly Gln Pro Pro Gly Pro Gly Gly Gly Pro Pro Phe Leu 
 1185                1190                1195                1200
Pro Ser Glu Asp Leu Gln Glu Arg Leu Tyr Leu Asn Arg Ser Leu Leu 
                 1205                1210                1215
Thr Ala Ile Ser Ala Gln Arg Val Leu Pro Phe Asp Asp Asn Ile Cys 
             1220                1225                1230
Leu Arg Glu Pro Cys Glu Asn Tyr Met Arg Cys Val Ser Val Leu Arg 
         1235                1240                1245
Phe Asp Ser Ser Ala Pro Phe Ile Ala Ser Ser Ser Val Leu Phe Arg 
     1250                1255                1260
Pro Ile His Pro Val Gly Gly Leu Arg Cys Arg Cys Pro Pro Gly Phe 
 1265                1270                1275                1280
Thr Gly Asp Tyr Cys Glu Thr Glu Val Asp Leu Cys Tyr Ser Arg Pro 
                 1285                1290                1295
Cys Gly Pro His Gly Arg Cys Arg Ser Arg Glu Gly Gly Tyr Thr Cys 
             1300                1305                1310
Leu Cys Arg Asp Gly Tyr Thr Gly Glu His Cys Glu Val Ser Ala Arg 
         1315                1320                1325
Ser Gly Arg Cys Thr Pro Gly Val Cys Lys Asn Gly Gly Thr Cys Val 
     1330                1335                1340
Asn Leu Leu Val Gly Gly Phe Lys Cys Asp Cys Pro Ser Gly Asp Phe 
 1345                1350                1355                1360
Glu Lys Pro Tyr Cys Gln Val Thr Thr Arg Ser Phe Pro Ala His Ser 
                 1365                1370                1375
Phe Ile Thr Phe Arg Gly Leu Arg Gln Arg Phe His Phe Thr Leu Ala 
             1380                1385                1390
Leu Ser Phe Ala Thr Lys Glu Arg Asp Gly Leu Leu Leu Tyr Asn Gly 
         1395                1400                1405
Arg Phe Asn Glu Lys His Asp Phe Val Ala Leu Glu Val Ile Gln Glu 
     1410                1415                1420
Gln Val Gln Leu Thr Phe Ser Ala Gly Glu Ser Thr Thr Thr Val Ser 
 1425                1430                1435                1440
Pro Phe Val Pro Gly Gly Val Ser Asp Gly Gln Trp His Thr Val Gln 
                 1445                1450                1455
Leu Lys Tyr Tyr Asn Lys Pro Leu Leu Gly Gln Thr Gly Leu Pro Gln 
             1460                1465                1470
Gly Pro Ser Glu Gln Lys Val Ala Val Val Thr Val Asp Gly Cys Asp 
         1475                1480                1485
Thr Gly Val Ala Leu Arg Phe Gly Ser Val Leu Gly Asn Tyr Ser Cys 
     1490                1495                1500
Ala Ala Gln Gly Thr Gln Gly Gly Ser Lys Lys Ser Leu Asp Leu Thr 
 1505                1510                1515                1520
Gly Pro Leu Leu Leu Gly Gly Val Pro Asp Leu Pro Glu Ser Phe Pro 
                 1525                1530                1535
Val Arg Met Arg Gln Phe Val Gly Cys Met Arg Asn Leu Gln Val Asp 
             1540                1545                1550
Ser Arg His Ile Asp Met Ala Asp Phe Ile Ala Asn Asn Gly Thr Val 
         1555                1560                1565
Pro Gly Cys Pro Ala Lys Lys Asn Val Cys Asp Ser Asn Thr Cys His 
     1570                1575                1580
Asn Gly Gly Thr Cys Val Asn Gln Trp Asp Ala Phe Ser Cys Glu Cys 
 1585                1590                1595                1600
Pro Leu Gly Phe Gly Gly Lys Ser Cys Ala Gln Glu Met Ala Asn Pro 
                 1605                1610                1615
Gln His Phe Leu Gly Ser Ser Leu Val Ala Trp His Gly Leu Ser Leu 
             1620                1625                1630
Pro Ile Ser Gln Pro Trp Tyr Leu Ser Leu Met Phe Arg Thr Arg Gln 
         1635                1640                1645
Ala Asp Gly Val Leu Leu Gln Ala Ile Thr Arg Gly Arg Ser Thr Ile 
     1650                1655                1660
Thr Leu Gln Leu Arg Glu Gly His Val Met Leu Ser Val Glu Gly Thr 
 1665                1670                1675                1680
Gly Leu Gln Ala Ser Ser Leu Arg Leu Glu Pro Gly Arg Ala Asn Asp 
                 1685                1690                1695
Gly Asp Trp His His Ala Gln Leu Ala Leu Gly Ala Ser Gly Gly Pro 
             1700                1705                1710
Gly His Ala Ile Leu Ser Phe Asp Tyr Gly Gln Gln Arg Ala Glu Gly 
         1715                1720                1725
Asn Leu Gly Pro Arg Leu His Gly Leu His Leu Ser Asn Ile Thr Val 
     1730                1735                1740
Gly Gly Ile Pro Gly Pro Ala Gly Gly Val Ala Arg Gly Phe Arg Gly 
 1745                1750                1755                1760
Cys Leu Gln Gly Val Arg Val Ser Asp Thr Pro Glu Gly Val Asn Ser 
                 1765                1770                1775
Leu Asp Pro Ser His Gly Glu Ser Ile Asn Val Glu Gln Gly Cys Ser 
             1780                1785                1790
Leu Pro Asp Pro Cys Asp Ser Asn Pro Cys Pro Ala Asn Ser Tyr Cys 
         1795                1800                1805
Ser Asn Asp Trp Asp Ser Tyr Ser Cys Ser Cys Asp Pro Gly Tyr Tyr 
     1810                1815                1820
Gly Asp Asn Cys Thr Asn Val Cys Asp Leu Asn Pro Cys Glu His Gln 
 1825                1830                1835                1840
Ser Val Cys Thr Arg Lys Pro Ser Ala Pro His Gly Tyr Thr Cys Glu 
                 1845                1850                1855
Cys Pro Pro Asn Tyr Leu Gly Pro Tyr Cys Glu Thr Arg Ile Asp Gln 
             1860                1865                1870
Pro Cys Pro Arg Gly Trp Trp Gly His Pro Thr Cys Gly Pro Cys Asn 
         1875                1880                1885
Cys Asp Val Ser Lys Gly Phe Asp Pro Asp Cys Asn Lys Thr Ser Gly 
     1890                1895                1900
Glu Cys His Cys Lys Glu Asn His Tyr Arg Pro Pro Gly Ser Pro Thr 
 1905                1910                1915                1920
Cys Leu Leu Cys Asp Cys Tyr Pro Thr Gly Ser Leu Ser Arg Val Cys 
                 1925                1930                1935
Asp Pro Glu Asp Gly Gln Cys Pro Cys Lys Pro Gly Val Ile Gly Arg 
             1940                1945                1950
Gln Cys Asp Arg Cys Asp Asn Pro Phe Ala Glu Val Thr Thr Asn Gly 
         1955                1960                1965
Cys Glu Val Asn Tyr Asp Ser Cys Pro Arg Ala Ile Glu Ala Gly Ile 
     1970                1975                1980
Trp Trp Pro Arg Thr Arg Phe Gly Leu Pro Ala Ala Ala Pro Cys Pro 
 1985                1990                1995                2000
Lys Gly Ser Phe Gly Thr Ala Val Arg His Cys Asp Glu His Arg Gly 
                 2005                2010                2015
Trp Leu Pro Pro Asn Leu Phe Asn Cys Thr Ser Ile Thr Phe Ser Glu 
             2020                2025                2030
Leu Lys Gly Phe Ala Glu Arg Leu Gln Arg Asn Glu Ser Gly Leu Asp 
         2035                2040                2045
Ser Gly Arg Ser Gln Gln Leu Ala Leu Leu Leu Arg Asn Ala Thr Gln 
     2050                2055                2060
His Thr Ala Gly Tyr Phe Gly Ser Asp Val Lys Val Ala Tyr Gln Leu 
 2065                2070                2075                2080
Ala Thr Arg Leu Leu Ala His Glu Ser Thr Gln Arg Gly Phe Gly Leu 
                 2085                2090                2095
Ser Ala Thr Gln Asp Val His Phe Thr Glu Asn Leu Leu Arg Val Gly 
             2100                2105                2110
Ser Ala Leu Leu Asp Thr Ala Asn Lys Arg His Trp Glu Leu Ile Gln 
         2115                2120                2125
Gln Thr Glu Gly Gly Thr Ala Trp Leu Leu Gln His Tyr Glu Ala Tyr 
     2130                2135                2140
Ala Ser Ala Leu Ala Gln Asn Met Arg His Thr Tyr Leu Ser Pro Phe 
 2145                2150                2155                2160
Thr Ile Val Thr Pro Asn Ile Val Ile Ser Val Val Arg Leu Asp Lys 
                 2165                2170                2175
Gly Asn Phe Ala Gly Ala Lys Leu Pro Arg Tyr Glu Ala Leu Arg Gly 
             2180                2185                2190
Glu Gln Pro Pro Asp Leu Glu Thr Thr Val Ile Leu Pro Glu Ser Val 
         2195                2200                2205
Phe Arg Glu Thr Pro Pro Val Val Arg Pro Ala Gly Pro Gly Glu Ala 
     2210                2215                2220
Gln Glu Pro Glu Glu Leu Ala Arg Arg Gln Arg Arg His Pro Glu Leu 
 2225                2230                2235                2240
Ser Gln Gly Glu Ala Val Ala Ser Val Ile Ile Tyr Arg Thr Leu Ala 
                 2245                2250                2255
Gly Leu Leu Pro His Asn Tyr Asp Pro Asp Lys Arg Ser Leu Arg Val 
             2260                2265                2270
Pro Lys Arg Pro Ile Ile Asn Thr Pro Val Val Ser Ile Ser Val His 
         2275                2280                2285
Asp Asp Glu Glu Leu Leu Pro Arg Ala Leu Asp Lys Pro Val Thr Val 
     2290                2295                2300
Gln Phe Arg Leu Leu Glu Thr Glu Glu Arg Thr Lys Pro Ile Cys Val 
 2305                2310                2315                2320
Phe Trp Asn His Ser Ile Leu Val Ser Gly Thr Gly Gly Trp Ser Ala 
                 2325                2330                2335
Arg Gly Cys Glu Val Val Phe Arg Asn Glu Ser His Val Ser Cys Gln 
             2340                2345                2350
Cys Asn His Met Thr Ser Phe Ala Val Leu Met Asp Val Ser Arg Arg 
         2355                2360                2365
Glu Asn Gly Glu Ile Leu Pro Leu Lys Thr Leu Thr Tyr Val Ala Leu 
     2370                2375                2380
Gly Val Thr Leu Ala Ala Leu Leu Leu Thr Phe Phe Phe Leu Thr Leu 
 2385                2390                2395                2400
Leu Arg Ile Leu Arg Ser Asn Gln His Gly Ile Arg Arg Asn Leu Thr 
                 2405                2410                2415
Ala Ala Leu Gly Leu Ala Gln Leu Val Phe Leu Leu Gly Ile Asn Gln 
             2420                2425                2430
Ala Asp Leu Pro Phe Ala Cys Thr Val Ile Ala Ile Leu Leu His Phe 
         2435                2440                2445
Leu Tyr Leu Cys Thr Phe Ser Trp Ala Leu Leu Glu Ala Leu His Leu 
     2450                2455                2460
Tyr Arg Ala Leu Thr Glu Val Arg Asp Val Asn Thr Gly Pro Met Arg 
 2465                2470                2475                2480
Phe Tyr Tyr Met Leu Gly Trp Gly Val Pro Ala Phe Ile Thr Gly Leu 
                 2485                2490                2495
Ala Val Gly Leu Asp Pro Glu Gly Tyr Gly Asn Pro Asp Phe Cys Trp 
             2500                2505                2510
Leu Ser Ile Tyr Asp Thr Leu Ile Trp Ser Phe Ala Gly Pro Val Ala 
         2515                2520                2525
Phe Ala Val Ser Met Ser Val Phe Leu Tyr Ile Leu Ala Ala Arg Ala 
     2530                2535                2540
Ser Cys Ala Ala Gln Arg Gln Gly Phe Glu Lys Lys Gly Pro Val Ser 
 2545                2550                2555                2560
Gly Leu Gln Pro Ser Phe Ala Val Leu Leu Leu Leu Ser Ala Thr Trp 
                 2565                2570                2575
Leu Leu Ala Leu Leu Ser Val Asn Ser Asp Thr Leu Leu Phe His Tyr 
             2580                2585                2590
Leu Phe Ala Thr Cys Asn Cys Ile Gln Gly Pro Phe Ile Phe Leu Ser 
         2595                2600                2605
Tyr Val Val Leu Ser Lys Glu Val Arg Lys Ala Leu Lys Leu Ala Cys 
     2610                2615                2620
Ser Arg Lys Pro Ser Pro Asp Pro Ala Leu Thr Thr Lys Ser Thr Leu 
 2625                2630                2635                2640
Thr Ser Ser Tyr Asn Cys Pro Ser Pro Tyr Ala Asp Gly Arg Leu Tyr 
                 2645                2650                2655
Gln Pro Tyr Gly Asp Ser Ala Gly Ser Leu His Ser Thr Ser Arg Ser 
             2660                2665                2670
Gly Lys Ser Gln Pro Ser Tyr Ile Pro Phe Leu Leu Arg Glu Glu Ser 
         2675                2680                2685
Ala Leu Asn Pro Gly Gln Gly Pro Pro Gly Leu Gly Asp Pro Gly Ser 
     2690                2695                2700
Leu Phe Leu Glu Gly Gln Asp Gln Gln His Asp Pro Asp Thr Asp Ser 
 2705                2710                2715                2720
Asp Ser Asp Leu Ser Leu Glu Asp Asp Gln Ser Gly Ser Tyr Ala Ser 
                 2725                2730                2735
Thr His Ser Ser Asp Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
             2740                2745                2750
Ala Ala Phe Pro Gly Glu Gln Gly Trp Asp Ser Leu Leu Gly Pro Gly 
         2755                2760                2765
Ala Glu Arg Leu Pro Leu His Ser Thr Pro Lys Asp Gly Gly Pro Gly 
     2770                2775                2780
Pro Gly Lys Ala Pro Trp Pro Gly Asp Phe Gly Thr Thr Ala Lys Glu 
 2785                2790                2795                2800
Ser Ser Gly Asn Gly Ala Pro Glu Glu Arg Leu Arg Glu Asn Gly Asp 
                 2805                2810                2815
Ala Leu Ser Arg Glu Gly Ser Leu Gly Pro Leu Pro Gly Ser Ser Ala 
             2820                2825                2830
Gln Pro His Lys Gly Ile Leu Lys Lys Lys Cys Leu Pro Thr Ile Ser 
         2835                2840                2845
Glu Lys Ser Ser Leu Leu Arg Leu Pro Leu Glu Gln Cys Thr Gly Ser 
     2850                2855                2860
Ser Arg Gly Ser Ser Ala Ser Glu Gly Ser Arg Gly Gly Pro Pro Pro 
 2865                2870                2875                2880
Arg Pro Pro Pro Arg Gln Ser Leu Gln Glu Gln Leu Asn Gly Val Met 
                 2885                2890                2895
Pro Ile Ala Met Ser Ile Lys Ala Gly Thr Val Asp Glu Asp Ser Ser 
             2900                2905                2910
Gly Ser Glu Phe Leu Phe Phe Asn Phe Leu His 
         2915                2920



<210> 211
<211> 11868
<212> DNA
<213> Rattus norvegicus
<308> AB011528
<400> 211

agcaaacca  ccgagcggc  gggagccat  ttggagcgt  gggaggcgg  agcggcgcc  60
ggaatgctg  ggtgggggc  gcaaaagcc  gggccgtat  ccaaacggg  tctggccgc  120
gagtagatg  tgcccagag  gcagtggcg  cgcggaccg  cgggcagag  ggccgaggg  180
cggggcggt  gcaggggcc  aggaggggg  cagagcagc  gggcgggcc  aaggcccgg  240
cccgggcgg  gggcggcgg  ggccgtgac  ggaggcggg  gtgatggcg  ggcggcctc  300
atggtgggg  ctcccggga  cgtcgaccc  gttactact  ctccttctc  tctctttgt  360
cccgtctag  cgggaggag  tggggggcg  tggggatca  ggctgggac  caggggtag  420
tactgctac  gggccaaga  ctcaaatcg  cagtggagc  gtagctctt  gtcccgagt  480
tccaggcgt  tgggaagat  gagatcctg  cctgggggt  agggaacct  tcttcatga  540
gctccgagt  ggtaggcaa  acgcccgga  tggtcgagg  gcccctgag  aaccaaacc  600
ggagccggt  gtccaggca  taggtagtc  cgagcaaga  gcaggtcag  gttcgggat  660
tttgttatg  tggcaccca  agatctcct  ttgtgggcg  acagggcat  tacgaagag  720
tagtttgcc  ctagatgct  tgtccccag  ggattctga  ctgaggaac  gctctcctc  780
cccttcgga  cttctggct  agcctgata  ccccaggcc  gtggccttc  aacgtaatg  840
taggagaag  atccgcaaa  gagtggaaa  ctttcgctg  tgcgggaaa  tatgggagc  900
aggacacaa  ggtcagggt  agagatccg  gacttccac  gtggatagg  gaccccttc  960
gcgggactg  ctccccggc  ctttgggat  tggcctggg  gaggattca  caccacgtg  1020
tgtgaggac  gctcctgcg  cgggttcag  acctcacga  tctcggaca  ctcccgagc  1080
catgcgctc  cgcggtctc  tccgccgcg  tttcctctt  gagcgccct  ggccgcgcc  1140
tcccggatt  ccgactggt  ctgaagcca  gcgaatact  tcaacgaac  aggctcgtt  1200
ccgtcgtgc  gcaaaccgc  acccgcagt  tcctcaata  aactaccaa  cacttgtac  1260
tgaaaatga  gcagcgggc  cagctgtgc  gcgcgtggt  gcgcaagac  cggacccag  1320
cgaagccgg  cgcctcgtc  actcgctgg  ggcgctcat  aacagtcgc  cgctggagc  1380
tttcagcat  gatcctcag  gtggcctca  acgcacggc  gccgctctg  accgtgaga  1440
tatggaacg  cactacctt  gagtgactg  acaggacca  ggctcaccg  gcctctcag  1500
taccaccat  gtggcggtg  cagtagctg  ccgcaacga  cacgcgcca  tgtttgagc  1560
agcccagta  cgggaaaca  ttcgtgaga  tgtggaaga  ggctacccc  tcctgcagt  1620
gcgtgccac  gacggtgac  cgccaccta  tgccaacct  cgctaccgc  tcgtggggt  1680
gccagctgc  cgtaccgca  cggccgctg  tttcgagat  gatccacgg  ccggcctta  1740
cagcactag  ggccgcgtg  accgggaac  catggaaag  tatgagctg  tggtagagg  1800
tagtgacca  ggtcaggag  ctgggccac  ttcagccac  gtacgagtg  acataactg  1860
gctggatga  aatgataac  ctccccagt  cagcgagaa  cgctatgtg  ctcaggtgc  1920
tgaggatgt  cgccctcac  cggtggtgc  acgtgtcac  gccacggac  aggacaagg  1980
tgccaatgg  ttggtacat  ataacatca  cagcggcaa  agccggggc  attttgcca  2040
cgatagtct  acgggtgag  tacaggtaa  ggcacctct  gactttgag  cagagagag  2100
atacgcttt  cgtatccgg  cacaagatg  aggccggcc  ccactgtcc  acaacacag  2160
cctggcaag  atccaggtg  tagacatca  tgatcatag  cctatcttt  tcagcacac  2220
ctttcaggt  tctgttttg  aaaatgcac  cctgggtca  tcagtcatt  acattcagg  2280
agtggacgc  gatcatggg  agaactcca  gttagagta  tctttaact  gcgtggcat  2340
agacacacc  tttgtgata  atagtgcca  tggctgggt  tctgtgagt  gtcccctgg  2400
ccgtgaatc  gtggaacat  acttctttg  ggtggaggc  cgagaccat  gttcacccc  2460
actctctgc  tcagccagt  tcacagtaa  tgtgttgga  gtcaacgac  atcggcctg  2520
gttcaccat  aaagagtac  accttcggc  caacgagga  gcagcggtg  gcaccagcg  2580
ggtcagtgt  actgcggta  atcgagatg  caacagtgc  atcagctac  aaatcacag  2640
tggcaacac  cggaaccga  tcgccatca  cacccaagg  ggcatgggt  tagtgaccc  2700
ggctctgcc  ctggattac  agcaggaac  ctacttcaa  ctggtgctg  ctgcatctg  2760
ccgtgccct  cacgaccac  gctatgtgc  tatcaacat  acagatgcc  acacacaca  2820
gcctgtctt  caaagcgct  actactcag  gagcatgaa  gaagaccgc  cagtgggta  2880
caccgtggt  gtcatcagt  cttctgatg  tgacgtggg  gaaaacgcc  gtatcacct  2940
ccttctgga  gacaacctg  cccagttcc  aatcgatgc  gactcaggg  ccattacac  3000
acaagctcc  ctggactat  aggaccaag  gacctatac  ctggccatt  ctgctcggg  3060
caacggtat  ccacagaag  cagatacca  atatgtgga  gttatggta  acgacgtga  3120
tgacaatgc  ccccagttt  tggcctccc  ctatacagg  ttggtctct  aagatgctc  3180
acctttcac  agtgttctg  agatctcag  cactgaccg  gatgctcat  ccaatggcc  3240
ggtccaata  actttccag  atggggaag  tggggatgg  gattttacc  ttgagccca  3300
ctctggcat  gtcaggact  tgaggcgac  ggaccggga  gcggtgcca  tgtatgagc  3360
gactgccta  gcagtggac  gtggcgtgc  cccactgag  actccagtc  gcatccagg  3420
gactgtaca  gacgtgaat  acaatgcac  tgtcttccc  gctgaggag  ttgaagtga  3480
ggtgaagga  aacagcatt  tggggtcgg  ggtggctca  atcaccgca  tggaccctg  3540
tgatggccc  aatgctcat  ttatgtacc  gatcgtgga  gggaacatc  ccgagctgt  3600
ccaaatgga  atcttctct  gagaactca  agcactcat  gacctggat  atgaggctc  3660
tcaggaata  gtgattgtg  tgcaggcca  atctgctcc  ctagttagc  gggccaccg  3720
gcatgtacg  ctggtcgac  agaacgata  cagtcctgt  ctcaacaac  tccagatcc  3780
ctttaacaa  tatgtatcc  accgatctg  cactttccc  tccggcatc  tcgggcgaa  3840
cccagctta  gacccggat  tctctgacc  cctctttta  tcctttgag  ggggcaatg  3900
actgcagct  ttagtggtc  accaaacca  tggggagct  cgactcagc  gaaagttag  3960
caacaatcg  ccactagtg  cgtccatgt  ggtaacagt  acagatggc  tgcatagtg  4020
tacagccca  tgtgttctg  gtgtggtca  catcacaga  gagttgctg  ccaacagct  4080
gactgttcg  ctggagaac  tgtggcaag  gcgtttcct  tcaccgctg  tgggtcatt  4140
tcttgaagg  gtggctgca  tgctcgcaa  acctaccga  gacgttttc  tcttcaaca  4200
ccagaacga  acggatgtg  ggggcaccg  gctcaacgt  agcttctca  cgctggcac  4260
tcgtggggc  ggggcaggc  ctgcagggc  ctggttcag  tccgaagag  tacaggagc  4320
actgtatgt  cgccgtgcc  ccttggcgg  ccgctcgct  ctcgacgtg  taccctttg  4380
cgacaacgt  tgcctgcgc  agccgtgcg  gaactacat  aaatgcgtg  cagtcctcc  4440
ctttgactc  tccgcgccc  ttctggcct  agcctccac  ctcttccga  ccatccaac  4500
catcgcggg  ctgcgctgc  gctgtccgc  tggcttcac  ggagacttc  gcgagacag  4560
gctcgacct  tgctactcg  acccttgtc  caatggcgg  gcgtgcgcg  ggcgcgagg  4620
aggctacac  tgcgtgtgc  gcccgcgct  caccgggga  gactgcgag  tggacactg  4680
agctggacg  tgtgtgccc  gtgtctgcc  caacggggg  acctgcacc  acgcaccca  4740
tggcggctt  cgttgccag  gccccgcgg  cggcgcttt  gagggcccg  gctgtgagg  4800
ggccgcacg  tcctttcct  ccagttcct  cgtcatgtt  cgcggtctg  gacagcgct  4860
ccacctcac  ctgtccctc  cgtttgcaa  tgtgcaacc  agcgggcta  tcttctaca  4920
cgggcgcct  aatgagaag  atgactttt  ggctctaga  cttgtagct  gtcaagtac  4980
gcttacata  tccacgggt  aatccagca  agtggtcag  cccacagtg  caggaggct  5040
gagtgacgg  cagtggcat  cagtgcatc  gagatacta  aacaagccc  ggacagatg  5100
gctaggggg  gctcagggc  cttcgaagg  caaggtggc  gtgttgagt  tggatgact  5160
caacgtggc  gtggctctg  ggtttggtg  tgagatcgg  aactactcg  gtgcagctg  5220
tggtgtgca  acaagctcc  agaagtccc  ggacctgac  ggccctctg  ttttggggg  5280
tgtccccaa  cttcccgag  acttccctg  gtcccgcaa  gacttcatc  gctgcatgc  5340
agacttgca  attgatggc  gccgagtgg  catggcagc  tttgtcgcc  acaatggca  5400
tacagcagg  tgtcaggcc  agtcacact  ttgtgcctc  ggcccctgc  agaacggtg  5460
cctctgctc  gagcgctgg  gcggcttca  ctgtgattg  cctgtgggc  ttggtggca  5520
agattgtcg  ctcacaatg  cccatccct  ccatttcca  ggcaacggg  ccctgagtt  5580
ggactttgg  aatgacatg  ctgtgtctg  gccatggta  ctgggacta  cgtttcgaa  5640
acgggcaac  aaaggggtc  tgatgcaag  gcagcttgg  ccacatagt  tgctcctct  5700
caagctaga  caagggttg  tgtctgtga  actcagtag  gcctcgggc  acgctgtcc  5760
cctcttgct  gaccagatg  ctgtcagcg  tggccggtg  catgacctt  ggctggagc  5820
gcaggagga  ccaggtggc  gaaggggcc  ccatatctt  atggtttca  tggacttca  5880
cctcttcca  gacaccatg  ccatgggga  tgagctgga  ggcctgaaa  taaagcatc  5940
ccacgtggg  ggcccgccc  ccagcagta  ggaggaggg  cctcagggt  tggttggct  6000
tattcaggg  gtgtggact  gctttactc  ctttgggtc  tcagccctg  cacctccca  6060
ccacagaat  aatgtggag  ctggctgca  tgtgaccaa  ccctgtgca  ctgggccct  6120
tcctcctca  gctaactgc  aagacctct  gcagacctt  tcctgtacc  gttggccag  6180
ttactacgg  ccaggctgt  tggatgcct  cctcctgaa  ccttgtcaa  accaggggt  6240
gtgccggca  ctccaagga  gcccccacg  ctatacctg  gactgtgca  gtggctatt  6300
tggtcagca  tgtgagcac  gaatggatc  gcagtgccc  cggggatgg  ggggaagcc  6360
aacctgtgg  ccctgcaac  gtgatgtcc  caagggctt  gaccccaac  gcaacaaga  6420
aagtggcca  tgccactgc  aggagttcc  ctatcgacc  aggggcagt  actcatgcc  6480
cccatgtga  tgctaccct  tgggctcca  ctcccgctc  tgtgcaccc  acagcgggc  6540
gtgcccctg  cgcccagga  cccttggcc  tcagtgtaa  agctgtgat  gcccctttg  6600
agaggtgac  gccagtggt  gccgagtac  ctacgatgc  tgccccaag  ccctgagat  6660
tggtgtgtg  tggccccag  ctaagtttg  tgttttggc  acagtaccc  gtccccggg  6720
ggccttggg  ttgcggggt  caggtgctg  ggtgcggct  tgtgatgaa  accacggtt  6780
gctggagcc  gacttcttc  actgtacct  tcctgcctt  cgagagctt  gtctgctgt  6840
ggatggcct  gagctgaac  agacggcac  ggatactgt  gaggccaag  agcttgctc  6900
gaggctgcg  gaggtgacc  gccagactg  ccactactt  agccaagat  tccgagtca  6960
tgcccgctt  ttggcctac  tgctggctt  cgagagcca  cagcagggc  tcgggctga  7020
agccacaca  gatgcccac  tcaatgaga  ccttctatg  gctggttct  cactgctgg  7080
tccagagac  ggagacttg  gggcagccc  ggggcagcg  gcccctggg  gctccccgg  7140
tagtgcagg  ctggtgcgg  atctggagg  atatgcagc  acacttgca  ggaacatgg  7200
cctgacata  ctgaatcct  tcggactag  cacacccaa  atcatgctc  gcattgacc  7260
tatggagca  cctagttca  cccagggag  ccaccgtta  ccccgctac  acagcaacc  7320
tttccgggg  caggacgcc  gggatcctc  tactcatgt  ctactgcct  cccagtccc  7380
acagccatc  ccttctgaa  ttctgccca  aagcagcaa  gcagaaaac  ccacagcct  7440
cggtgtggt  tccccacct  cccctctgg  gcctgagtc  gagcctggg  tctccatag  7500
cattctact  gtgtatcga  ccttgggag  gcttctccc  gcccagttc  aagctgagc  7560
ccggggcgc  aggcttccc  agaaccctg  tatgaactc  ccggtggtc  gcgtggctg  7620
ttttcgtgg  cgcaacttc  tcagaggtg  cctagtgtc  ccaatcaac  ttgagttcc  7680
cctactaca  acagcgaat  ggagcaagg  gatctgtgt  cagtgggac  cacctggcc  7740
ggcagacca  catgggatg  ggacggcaa  ggactgtga  ctggtacac  ggaatggct  7800
ccatgcacg  tgtcgctgt  gccggacgg  cactttcgg  gtccttatg  atgcctctc  7860
ccgtgagcg  ctagaggga  acctagagc  gctggcggt  ttcactcat  tggtcgtgg  7920
ggcgtctgt  actgcgcta  ttctgaccg  agctgtcct  ctgagcctg  gcagcctca  7980
gtccaacgt  cgtgggatc  atgccaatg  ggcagctgc  ctgggagtg  cagagcttc  8040
cttcctgct  ggaatccac  ggacccaca  ccagctgct  tgcacagtg  tcgccatcc  8100
cctacatta  ttcttcctc  gcaccttcg  gtggctcct  gtgcagggc  tgcacctct  8160
ccgaatgca  gttgagcct  gaaatgtgg  tcgtggcgc  atgcgcttc  accatgccc  8220
gggctgggg  gtccctgct  tgttgttgg  ccttgctgt  gggctggac  cggagggct  8280
tgggaaccc  gacttctgc  ggatctcca  ccacgaacc  cttatctgg  gttttgccg  8340
tcctatagt  cttgttatt  tgatgaatg  aatcatgtt  ctcctcgcg  cccgcacat  8400
ctgctccac  gggcagagg  aggccaaga  gacctctgt  ctcaggacc  ttcgcagct  8460
ttttctgct  cttctgctg  tcagtgcct  ctggctctt  ggccttctg  cagtcaacc  8520
cagcgtact  gccttccac  acctccatg  tggactctg  ggcctccag  gcctggctg  8580
gctgctgct  ttctgtgtc  tgaatgcag  tgctcgggc  gcctggacg  cagcctgtc  8640
aggcaagaa  gcagctccc  aggaaacaa  gccagcacc  gggccgggg  ctggggcct  8700
taacaacac  gccctcttt  aggagagtg  ccttatccg  atcactctt  gtgcctcca  8760
cgtctcttc  gtgagcagt  cccgctcag  cagggccca  gaccaggac  gccagcggg  8820
ccgcagcta  ctcagggac  atgttctgg  tcgacacgg  tcgaccgct  agcacgctg  8880
gcacagcct  caggctcat  ccggcccca  tgacctgga  gtggctatg  tccatcgag  8940
cgctggtgc  gactctgac  ctgacagcg  cctgtcctt  gaggaggag  ggagcctat  9000
catcccatc  tcagagagc  aggacaatg  ccggactcg  gggcgtttc  aacgtccac  9060
ccgcagggc  gcccagagt  agaggctcc  tgcccaccc  aaagatgtg  acggcaatg  9120
cctactgtc  tactggcca  ccctggggg  gtgtgaggc  gcaccgtgc  ctctgcagg  9180
gtggggctc  gaaaggcgc  tcggactag  cagcaacaa  gacgcagcc  acaacaacc  9240
gcctgaact  gccttgacc  gtggagatg  aacctccct  ggccgggca  agcggcaga  9300
gaaaggcat  ctgaagaac  ggttgcagt  cccactggt  cctcagact  gaggcactc  9360
tgagctgtc  tggtgccgt  cagctacct  gggccaccg  gctgtgccg  ctgcctcct  9420
tggccgcat  tatgcaggt  ggggtacag  tagtctttc  cagccggcc  gccgctact  9480
ttctcgaga  cagctggac  tgctcttaa  gcgacagct  agtagggag  gactagaag  9540
ggtcccagt  cctgcacct  ttttgcacc  cctgagccg  ccaggctcc  aggaacgcc  9600
ggatactgc  ccagcccgc  tggaacccc  agatagggg  agcacacta  cacggagac  9660
gccccctcg  gactaccct  gaaccatgg  tggccgctt  gggtcacgg  atgcgctgg  9720
cttaggggc  ccccgagaa  ggttgagca  acttccccc  ccccgacgc  accgggacc  9780
tgacccaca  cacccacct  tgcccctgt  tccacagag  ccactctca  gggaccccc  9840
cttgccatc  aggcccctg  actctctat  taggatctc  aactctcgg  agcggctgg  9900
ccaagtgcc  agtcgacac  cctcccggg  ggcccttgg  ccagcccca  agcttctca  9960
agccaggga  gacccagcc  gcggcccta  ccatggtcc  tccacagag  aactggaca  10020
tctgtcctc  atccttgcc  ctttcaact  ctcagccct  tcttctgtg  agtcctcga  10080
cacaccctc  ggccctcac  ccactgcca  gccttccgc  acagcctct  cacttggac  10140
ttccacacc  cgctcagcc  catctcata  catctcgga  ttgtcacct  attcagaag  10200
tcccagaag  gagggtcac  cctgagggg  gaccagcaa  tgagaagcc  ccaaggggc  10260
gcggaggat  tgggctgac  gaagagact  caggactga  cccaaggca  ccttcctca  10320
gccctcccc  cagttcagt  cagtgaaat  tggaggtcc  tcctgtgcg  atctgtgag  10380
atgcgtgtg  caggtgcag  ggtgggggc  gagggagga  ttttataca  tttgtaact  10440
tgtaaccag  gagatatgc  tatgttatt  ttcagcttt  ccttctccc  ggggtcttg  10500
gactgggct  ggggcgggg  agaggatgg  agagagatg  attttggcc  cctttgggt  10560
cttagcaaa  catcatctc  tttctttca  ctctcggta  agtggacca  tccggccga  10620
ccactcttt  ccctcctct  cccccacac  gatctgaac  tttttgggg  ccagagtgc  10680
aatttggtc  ttgcatttt  tccgatgcc  caagggcca  actcctatt  gggggttgg  10740
cctggaaac  ggggccctc  ctcctcctc  tgggggctc  tgtgctcca  tcctccctg  10800
gggtgtgga  atgtattac  tggagtccc  gccgcttac  gccttaaga  ctaggactg  10860
tgctgcggg  gctggtgga  cagcagaag  cttgtttac  gatcaaggc  tccctttct  10920
cctctggga  ggacttggg  ctctaatca  acattccta  agcgggtgg  tggagggta  10980
actcctttc  ttgtccctc  ttcactagt  tgtggtgcc  ttgattcat  atactgtcc  11040
cttgagggc  ggggggggg  cagttagca  agggagcgg  aactaggga  cccaagacc  11100
agaatgtag  tgccacagt  tcccactgt  tacaggatc  tccctggca  caggctgca  11160
cagtggctg  cccaccttc  gttagtccc  tataaaggg  aaaatgacg  ttaggatcc  11220
gttcacaaa  ctctccttt  ttatttgtc  gatgtccag  tctggggac  ttaaatttt  11280
ttactttgt  tacaggcca  gattatttt  taaaatggt  gggttttat  tattgttta  11340
agcttaaaa  attgactta  acactttgt  tacagttca  aatgtttcc  cctctttgt  11400
tacaagtga  aggtagaaa  agtggggga  gggcctaaa  gacccacct  tgatgcccc  11460
cacctggcc  tcttgaggt  ggcttctaa  cccaacttt  cccaggtca  aggtcagcc  11520
agtcttcta  cagcttgcc  caaaggtgg  tcaggactg  ggttctgtg  aaacaccac  11580
cacccctac  ctgtgcata  tcttgggag  cagtgtctg  gattcaaat  ttcacttca  11640
tgtctgtgc  aaatcccac  agccaggtt  cccagctct  tttacccag  ctgaccccc  11700
cccttgaag  gctgagagg  ctgtccgtg  ggagagtgt  cttgctaac  aagtcctag  11760
ttctgtaga  gcccatctc  ggggtcccc  tccaacagt  gccctcttc  ctgtctgtg  11820
aaattgttc  gtgaagccg  gctctgttt  gggaataaa  ttctatag  11868



<210> 212
<211> 3313
<212> PRT
<213> Rattus norvegicus
<308> BAA32459
<400> 212

Met Ala Arg Arg Pro Leu Trp Trp Gly Leu Pro Gly Pro Ser Thr Pro 
  1               5                  10                  15
Leu Leu Leu Leu Leu Leu Phe Ser Leu Phe Pro Ser Ser Arg Glu Glu 
             20                  25                  30
Met Gly Gly Gly Gly Asp Gln Gly Trp Asp Pro Gly Val Ala Thr Ala 
         35                  40                  45
Thr Gly Pro Arg Ala Gln Ile Gly Ser Gly Ala Val Ala Leu Cys Pro 
     50                  55                  60
Glu Ser Pro Gly Val Trp Glu Asp Gly Asp Pro Gly Leu Gly Val Arg 
 65                  70                  75                  80
Glu Pro Val Phe Met Lys Leu Arg Val Gly Arg Gln Asn Ala Arg Asn 
                 85                  90                  95
Gly Arg Gly Ala Pro Glu Gln Pro Asn Arg Glu Pro Val Val Gln Ala 
             100                105                110
Leu Gly Ser Arg Glu Gln Glu Ala Gly Gln Gly Ser Gly Tyr Leu Leu 
         115                120                125
Cys Trp His Pro Glu Ile Ser Ser Cys Gly Arg Thr Gly His Leu Arg 
     130                135                140
Arg Gly Ser Leu Pro Leu Asp Ala Leu Ser Pro Gly Asp Ser Asp Leu 
 145                150                155                160
Arg Asn Ser Ser Pro His Pro Ser Glu Leu Leu Ala Gln Pro Asp Ser 
                 165                170                175
Pro Arg Pro Val Ala Phe Gln Arg Asn Gly Arg Arg Ser Ile Arg Lys 
             180                185                190
Arg Val Glu Thr Phe Arg Cys Cys Gly Lys Leu Trp Glu Pro Gly His 
         195                200                205
Lys Gly Gln Gly Glu Arg Ser Ala Thr Ser Thr Val Asp Arg Gly Pro 
     210                215                220
Leu Arg Arg Asp Cys Leu Pro Gly Ser Leu Gly Ser Gly Leu Gly Glu 
 225                230                235                240
Asp Ser Ala Pro Arg Ala Val Arg Thr Ala Pro Ala Pro Gly Ser Ala 
                 245                250                255
Pro His Glu Ser Arg Thr Ala Pro Glu Arg Met Arg Ser Arg Gly Leu 
             260                265                270
Phe Arg Arg Gly Phe Leu Phe Glu Arg Pro Gly Pro Arg Pro Pro Gly 
         275                280                285
Phe Pro Thr Gly Ala Glu Ala Lys Arg Ile Leu Ser Thr Asn Gln Ala 
     290                295                300
Arg Ser Arg Arg Ala Ala Asn Arg His Pro Gln Phe Pro Gln Tyr Asn 
 305                310                315                320
Tyr Gln Thr Leu Val Pro Glu Asn Glu Ala Ala Gly Thr Ala Val Leu 
                 325                330                335
Arg Val Val Ala Gln Asp Pro Asp Pro Gly Glu Ala Gly Arg Leu Val 
             340                345                350
Tyr Ser Leu Ala Ala Leu Met Asn Ser Arg Ser Leu Glu Leu Phe Ser 
         355                360                365
Ile Asp Pro Gln Ser Gly Leu Ile Arg Thr Ala Ala Ala Leu Asp Arg 
     370                375                380
Glu Ser Met Glu Arg His Tyr Leu Arg Val Thr Ala Gln Asp His Gly 
 385                390                395                400
Ser Pro Arg Leu Ser Ala Thr Thr Met Val Ala Val Thr Val Ala Asp 
                 405                410                415
Arg Asn Asp His Ala Pro Val Phe Glu Gln Ala Gln Tyr Arg Glu Thr 
             420                425                430
Leu Arg Glu Asn Val Glu Glu Gly Tyr Pro Ile Leu Gln Leu Arg Ala 
         435                440                445
Thr Asp Gly Asp Ala Pro Pro Asn Ala Asn Leu Arg Tyr Arg Phe Val 
     450                455                460
Gly Ser Pro Ala Ala Arg Thr Ala Ala Ala Ala Ala Phe Glu Ile Asp 
 465                470                475                480
Pro Arg Ser Gly Leu Ile Ser Thr Ser Gly Arg Val Asp Arg Glu His 
                 485                490                495
Met Glu Ser Tyr Glu Leu Val Val Glu Ala Ser Asp Gln Gly Gln Glu 
             500                505                510
Pro Gly Pro Arg Ser Ala Thr Val Arg Val His Ile Thr Val Leu Asp 
         515                520                525
Glu Asn Asp Asn Ala Pro Gln Phe Ser Glu Lys Arg Tyr Val Ala Gln 
     530                535                540
Val Arg Glu Asp Val Arg Pro His Thr Val Val Leu Arg Val Thr Ala 
 545                550                555                560
Thr Asp Lys Asp Lys Asp Ala Asn Gly Leu Val His Tyr Asn Ile Ile 
                 565                570                575
Ser Gly Asn Ser Arg Gly His Phe Ala Ile Asp Ser Leu Thr Gly Glu 
             580                585                590
Ile Gln Val Met Ala Pro Leu Asp Phe Glu Ala Glu Arg Glu Tyr Ala 
         595                600                605
Leu Arg Ile Arg Ala Gln Asp Ala Gly Arg Pro Pro Leu Ser Asn Asn 
     610                615                620
Thr Gly Leu Ala Ser Ile Gln Val Val Asp Ile Asn Asp His Ser Pro 
 625                630                635                640
Ile Phe Val Ser Thr Pro Phe Gln Val Ser Val Leu Glu Asn Ala Pro 
                 645                650                655
Leu Gly His Ser Val Ile His Ile Gln Ala Val Asp Ala Asp His Gly 
             660                665                670
Glu Asn Ser Arg Leu Glu Tyr Ser Leu Thr Gly Val Ala Ser Asp Thr 
         675                680                685
Pro Phe Val Ile Asn Ser Ala Thr Gly Trp Val Ser Val Ser Gly Pro 
     690                695                700
Leu Asp Arg Glu Ser Val Glu His Tyr Phe Phe Gly Val Glu Ala Arg 
 705                710                715                720
Asp His Gly Ser Pro Pro Leu Ser Ala Ser Ala Ser Val Thr Val Thr 
                 725                730                735
Val Leu Asp Val Asn Asp Asn Arg Pro Glu Phe Thr Met Lys Glu Tyr 
             740                745                750
His Leu Arg Leu Asn Glu Asp Ala Ala Val Gly Thr Ser Val Val Ser 
         755                760                765
Val Thr Ala Val Asp Arg Asp Ala Asn Ser Ala Ile Ser Tyr Gln Ile 
     770                775                780
Thr Gly Gly Asn Thr Arg Asn Arg Phe Ala Ile Ser Thr Gln Gly Gly 
 785                790                795                800
Met Gly Leu Val Thr Leu Ala Leu Pro Leu Asp Tyr Lys Gln Glu Arg 
                 805                810                815
Tyr Phe Lys Leu Val Leu Thr Ala Ser Asp Arg Ala Leu His Asp His 
             820                825                830
Cys Tyr Val His Ile Asn Ile Thr Asp Ala Asn Thr His Arg Pro Val 
         835                840                845
Phe Gln Ser Ala His Tyr Ser Val Ser Met Asn Glu Asp Arg Pro Val 
     850                855                860
Gly Ser Thr Val Val Val Ile Ser Ala Ser Asp Asp Asp Val Gly Glu 
 865                870                875                880
Asn Ala Arg Ile Thr Tyr Leu Leu Glu Asp Asn Leu Pro Gln Phe Arg 
                 885                890                895
Ile Asp Ala Asp Ser Gly Ala Ile Thr Leu Gln Ala Pro Leu Asp Tyr 
             900                905                910
Glu Asp Gln Val Thr Tyr Thr Leu Ala Ile Thr Ala Arg Asp Asn Gly 
         915                920                925
Ile Pro Gln Lys Ala Asp Thr Thr Tyr Val Glu Val Met Val Asn Asp 
     930                935                940
Val Asn Asp Asn Ala Pro Gln Phe Val Ala Ser His Tyr Thr Gly Leu 
 945                950                955                960
Val Ser Glu Asp Ala Pro Pro Phe Thr Ser Val Leu Gln Ile Ser Ala 
                 965                970                975
Thr Asp Arg Asp Ala His Ala Asn Gly Arg Val Gln Tyr Thr Phe Gln 
             980                985                990
Asn Gly Glu Asp Gly Asp Gly Asp Phe Thr Ile Glu Pro Thr Ser Gly 
         995                1000                1005
Ile Val Arg Thr Val Arg Arg Leu Asp Arg Glu Ala Val Pro Val Tyr 
     1010                1015                1020
Glu Leu Thr Ala Tyr Ala Val Asp Arg Gly Val Pro Pro Leu Arg Thr 
 1025                1030                1035                1040
Pro Val Ser Ile Gln Val Thr Val Gln Asp Val Asn Asp Asn Ala Pro 
                 1045                1050                1055
Val Phe Pro Ala Glu Glu Phe Glu Val Arg Val Lys Glu Asn Ser Ile 
             1060                1065                1070
Val Gly Ser Val Val Ala Gln Ile Thr Ala Val Asp Pro Asp Asp Gly 
         1075                1080                1085
Pro Asn Ala His Ile Met Tyr Gln Ile Val Glu Gly Asn Ile Pro Glu 
     1090                1095                1100
Leu Phe Gln Met Asp Ile Phe Ser Gly Glu Leu Thr Ala Leu Ile Asp 
 1105                1110                1115                1120
Leu Asp Tyr Glu Ala Arg Gln Glu Tyr Val Ile Val Val Gln Ala Thr 
                 1125                1130                1135
Ser Ala Pro Leu Val Ser Arg Ala Thr Val His Val Arg Leu Val Asp 
             1140                1145                1150
Gln Asn Asp Asn Ser Pro Val Leu Asn Asn Phe Gln Ile Leu Phe Asn 
         1155                1160                1165
Asn Tyr Val Ser Asn Arg Ser Asp Thr Phe Pro Ser Gly Ile Ile Gly 
     1170                1175                1180
Arg Ile Pro Ala Tyr Asp Pro Asp Val Ser Asp His Leu Phe Tyr Ser 
 1185                1190                1195                1200
Phe Glu Arg Gly Asn Glu Leu Gln Leu Leu Val Val Asn Gln Thr Ser 
                 1205                1210                1215
Gly Glu Leu Arg Leu Ser Arg Lys Leu Asp Asn Asn Arg Pro Leu Val 
             1220                1225                1230
Ala Ser Met Leu Val Thr Val Thr Asp Gly Leu His Ser Val Thr Ala 
         1235                1240                1245
Gln Cys Val Leu Arg Val Val Ile Ile Thr Glu Glu Leu Leu Ala Asn 
     1250                1255                1260
Ser Leu Thr Val Arg Leu Glu Asn Met Trp Gln Glu Arg Phe Leu Ser 
 1265                1270                1275                1280
Pro Leu Leu Gly His Phe Leu Glu Gly Val Ala Ala Val Leu Ala Thr 
                 1285                1290                1295
Pro Thr Glu Asp Val Phe Ile Phe Asn Ile Gln Asn Asp Thr Asp Val 
             1300                1305                1310
Gly Gly Thr Val Leu Asn Val Ser Phe Ser Ala Leu Ala Pro Arg Gly 
         1315                1320                1325
Ala Gly Ala Gly Ala Ala Gly Pro Trp Phe Ser Ser Glu Glu Leu Gln 
     1330                1335                1340
Glu Gln Leu Tyr Val Arg Arg Ala Ala Leu Ala Ala Arg Ser Leu Leu 
 1345                1350                1355                1360
Asp Val Leu Pro Phe Asp Asp Asn Val Cys Leu Arg Glu Pro Cys Glu 
                 1365                1370                1375
Asn Tyr Met Lys Cys Val Ser Val Leu Arg Phe Asp Ser Ser Ala Pro 
             1380                1385                1390
Phe Leu Ala Ser Ala Ser Thr Leu Phe Arg Pro Ile Gln Pro Ile Ala 
         1395                1400                1405
Gly Leu Arg Cys Arg Cys Pro Pro Gly Phe Thr Gly Asp Phe Cys Glu 
     1410                1415                1420
Thr Glu Leu Asp Leu Cys Tyr Ser Asn Pro Cys Arg Asn Gly Gly Ala 
 1425                1430                1435                1440
Cys Ala Arg Arg Glu Gly Gly Tyr Thr Cys Val Cys Arg Pro Arg Phe 
                 1445                1450                1455
Thr Gly Glu Asp Cys Glu Leu Asp Thr Glu Ala Gly Arg Cys Val Pro 
             1460                1465                1470
Gly Val Cys Arg Asn Gly Gly Thr Cys Thr Asn Ala Pro Asn Gly Gly 
         1475                1480                1485
Phe Arg Cys Gln Cys Pro Ala Gly Gly Ala Phe Glu Gly Pro Arg Cys 
     1490                1495                1500
Glu Val Ala Ala Arg Ser Phe Pro Pro Ser Ser Phe Val Met Phe Arg 
 1505                1510                1515                1520
Gly Leu Arg Gln Arg Phe His Leu Thr Leu Ser Leu Ser Phe Ala Thr 
                 1525                1530                1535
Val Gln Pro Ser Gly Leu Leu Phe Tyr Asn Gly Arg Leu Asn Glu Lys 
             1540                1545                1550
His Asp Phe Leu Ala Leu Glu Leu Val Ala Gly Gln Val Arg Leu Thr 
         1555                1560                1565
Tyr Ser Thr Gly Glu Ser Ser Thr Val Val Ser Pro Thr Val Pro Gly 
     1570                1575                1580
Gly Leu Ser Asp Gly Gln Trp His Thr Val His Leu Arg Tyr Tyr Asn 
 1585                1590                1595                1600
Lys Pro Arg Thr Asp Ala Leu Gly Gly Ala Gln Gly Pro Ser Lys Asp 
                 1605                1610                1615
Lys Val Ala Val Leu Ser Val Asp Asp Cys Asn Val Ala Val Ala Leu 
             1620                1625                1630
Arg Phe Gly Ala Glu Ile Gly Asn Tyr Ser Cys Ala Ala Ala Gly Val 
         1635                1640                1645
Gln Thr Ser Ser Lys Lys Ser Leu Asp Leu Thr Gly Pro Leu Leu Leu 
     1650                1655                1660
Gly Gly Val Pro Asn Leu Pro Glu Asn Phe Pro Val Ser Arg Lys Asp 
 1665                1670                1675                1680
Phe Ile Gly Cys Met Arg Asp Leu His Ile Asp Gly Arg Arg Val Asp 
                 1685                1690                1695
Met Ala Ala Phe Val Ala Asn Asn Gly Thr Thr Ala Gly Cys Gln Ala 
             1700                1705                1710
Lys Ser His Phe Cys Ala Ser Gly Pro Cys Lys Asn Gly Gly Leu Cys 
         1715                1720                1725
Ser Glu Arg Trp Gly Gly Phe Ser Cys Asp Cys Pro Val Gly Phe Gly 
     1730                1735                1740
Gly Lys Asp Cys Arg Leu Thr Met Ala His Pro Tyr His Phe Gln Gly 
 1745                1750                1755                1760
Asn Gly Thr Leu Ser Trp Asp Phe Gly Asn Asp Met Pro Val Ser Val 
                 1765                1770                1775
Pro Trp Tyr Leu Gly Leu Ser Phe Arg Thr Arg Ala Thr Lys Gly Val 
             1780                1785                1790
Leu Met Gln Val Gln Leu Gly Pro His Ser Val Leu Leu Cys Lys Leu 
         1795                1800                1805
Asp Gln Gly Leu Leu Ser Val Thr Leu Ser Arg Ala Ser Gly His Ala 
     1810                1815                1820
Val His Leu Leu Leu Asp Gln Met Thr Val Ser Asp Gly Arg Trp His 
 1825                1830                1835                1840
Asp Leu Arg Leu Glu Leu Gln Glu Glu Pro Gly Gly Arg Arg Gly His 
                 1845                1850                1855
His Ile Phe Met Val Ser Leu Asp Phe Thr Leu Phe Gln Asp Thr Met 
             1860                1865                1870
Ala Met Gly Ser Glu Leu Glu Gly Leu Lys Val Lys His Leu His Val 
         1875                1880                1885
Gly Gly Pro Pro Pro Ser Ser Lys Glu Glu Gly Pro Gln Gly Leu Val 
     1890                1895                1900
Gly Cys Ile Gln Gly Val Trp Thr Gly Phe Thr Pro Phe Gly Ser Ser 
 1905                1910                1915                1920
Ala Leu Pro Pro Pro Ser His Arg Ile Asn Val Glu Pro Gly Cys Thr 
                 1925                1930                1935
Val Thr Asn Pro Cys Ala Ser Gly Pro Cys Pro Pro His Ala Asn Cys 
             1940                1945                1950
Lys Asp Leu Trp Gln Thr Phe Ser Cys Thr Cys Trp Pro Gly Tyr Tyr 
         1955                1960                1965
Gly Pro Gly Cys Val Asp Ala Cys Leu Leu Asn Pro Cys Gln Asn Gln 
     1970                1975                1980
Gly Ser Cys Arg His Leu Gln Gly Gly Pro His Gly Tyr Thr Cys Asp 
 1985                1990                1995                2000
Cys Ala Ser Gly Tyr Phe Gly Gln His Cys Glu His Arg Met Asp Gln 
                 2005                2010                2015
Gln Cys Pro Arg Gly Trp Trp Gly Ser Pro Thr Cys Gly Pro Cys Asn 
             2020                2025                2030
Cys Asp Val His Lys Gly Phe Asp Pro Asn Cys Asn Lys Thr Ser Gly 
         2035                2040                2045
Gln Cys His Cys Lys Glu Phe His Tyr Arg Pro Arg Gly Ser Asp Ser 
     2050                2055                2060
Cys Leu Pro Cys Asp Cys Tyr Pro Val Gly Ser Thr Ser Arg Ser Cys 
 2065                2070                2075                2080
Ala Pro His Ser Gly Gln Cys Pro Cys Arg Pro Gly Ala Leu Gly Arg 
                 2085                2090                2095
Gln Cys Asn Ser Cys Asp Ser Pro Phe Ala Glu Val Thr Ala Ser Gly 
             2100                2105                2110
Cys Arg Val Leu Tyr Asp Ala Cys Pro Lys Ser Leu Arg Ser Gly Val 
         2115                2120                2125
Trp Trp Pro Gln Thr Lys Phe Gly Val Leu Ala Thr Val Pro Cys Pro 
     2130                2135                2140
Arg Gly Ala Leu Gly Leu Arg Gly Thr Gly Ala Ala Val Arg Leu Cys 
 2145                2150                2155                2160
Asp Glu Asp His Gly Trp Leu Glu Pro Asp Phe Phe Asn Cys Thr Ser 
                 2165                2170                2175
Pro Ala Phe Arg Glu Leu Ser Leu Leu Leu Asp Gly Leu Glu Leu Asn 
             2180                2185                2190
Lys Thr Ala Leu Asp Thr Val Glu Ala Lys Lys Leu Ala Gln Arg Leu 
         2195                2200                2205
Arg Glu Val Thr Gly Gln Thr Asp His Tyr Phe Ser Gln Asp Val Arg 
     2210                2215                2220
Val Thr Ala Arg Leu Leu Ala Tyr Leu Leu Ala Phe Glu Ser His Gln 
 2225                2230                2235                2240
Gln Gly Phe Gly Leu Thr Ala Thr Gln Asp Ala His Phe Asn Glu Asn 
                 2245                2250                2255
Leu Leu Trp Ala Gly Ser Ala Leu Leu Ala Pro Glu Thr Gly Asp Leu 
             2260                2265                2270
Trp Ala Ala Leu Gly Gln Arg Ala Pro Gly Gly Ser Pro Gly Ser Ala 
         2275                2280                2285
Gly Leu Val Arg His Leu Glu Glu Tyr Ala Ala Thr Leu Ala Arg Asn 
     2290                2295                2300
Met Asp Leu Thr Tyr Leu Asn Pro Val Gly Leu Val Thr Pro Asn Ile 
 2305                2310                2315                2320
Met Leu Ser Ile Asp Arg Met Glu Gln Pro Ser Ser Ser Gln Gly Ala 
                 2325                2330                2335
His Arg Tyr Pro Arg Tyr His Ser Asn Leu Phe Arg Gly Gln Asp Ala 
             2340                2345                2350
Trp Asp Pro His Thr His Val Leu Leu Pro Ser Gln Ser Pro Gln Pro 
         2355                2360                2365
Ser Pro Ser Glu Val Leu Pro Thr Ser Ser Asn Ala Glu Asn Ala Thr 
     2370                2375                2380
Ala Ser Gly Val Val Ser Pro Pro Ala Pro Leu Glu Pro Glu Ser Glu 
 2385                2390                2395                2400
Pro Gly Ile Ser Ile Val Ile Leu Leu Val Tyr Arg Ala Leu Gly Gly 
                 2405                2410                2415
Leu Leu Pro Ala Gln Phe Gln Ala Glu Arg Arg Gly Ala Arg Leu Pro 
             2420                2425                2430
Gln Asn Pro Val Met Asn Ser Pro Val Val Ser Val Ala Val Phe Arg 
         2435                2440                2445
Gly Arg Asn Phe Leu Arg Gly Ala Leu Val Ser Pro Ile Asn Leu Glu 
     2450                2455                2460
Phe Arg Leu Leu Gln Thr Ala Asn Arg Ser Lys Ala Ile Cys Val Gln 
 2465                2470                2475                2480
Trp Asp Pro Pro Gly Pro Ala Asp Gln His Gly Met Trp Thr Ala Arg 
                 2485                2490                2495
Asp Cys Glu Leu Val His Arg Asn Gly Ser His Ala Arg Cys Arg Cys 
             2500                2505                2510
Ser Arg Thr Gly Thr Phe Gly Val Leu Met Asp Ala Ser Pro Arg Glu 
         2515                2520                2525
Arg Leu Glu Gly Asp Leu Glu Leu Leu Ala Val Phe Thr His Val Val 
     2530                2535                2540
Val Ala Ala Ser Val Thr Ala Leu Val Leu Thr Ala Ala Val Leu Leu 
 2545                2550                2555                2560
Ser Leu Arg Ser Leu Lys Ser Asn Val Arg Gly Ile His Ala Asn Val 
                 2565                2570                2575
Ala Ala Ala Leu Gly Val Ala Glu Leu Leu Phe Leu Leu Gly Ile His 
             2580                2585                2590
Arg Thr His Asn Gln Leu Leu Cys Thr Val Val Ala Ile Leu Leu His 
         2595                2600                2605
Tyr Phe Phe Leu Ser Thr Phe Ala Trp Leu Leu Val Gln Gly Leu His 
     2610                2615                2620
Leu Tyr Arg Met Gln Val Glu Pro Arg Asn Val Asp Arg Gly Ala Met 
 2625                2630                2635                2640
Arg Phe Tyr His Ala Leu Gly Trp Gly Val Pro Ala Val Leu Leu Gly 
                 2645                2650                2655
Leu Ala Val Gly Leu Asp Pro Glu Gly Tyr Gly Asn Pro Asp Phe Cys 
             2660                2665                2670
Trp Ile Ser Ile His Glu Pro Leu Ile Trp Ser Phe Ala Gly Pro Ile 
         2675                2680                2685
Val Leu Val Ile Val Met Asn Gly Ile Met Phe Leu Leu Ala Ala Arg 
     2690                2695                2700
Thr Ser Cys Ser Thr Gly Gln Arg Glu Ala Lys Lys Thr Ser Val Leu 
 2705                2710                2715                2720
Arg Thr Leu Arg Ser Ser Phe Leu Leu Leu Leu Leu Val Ser Ala Ser 
                 2725                2730                2735
Trp Leu Phe Gly Leu Leu Ala Val Asn His Ser Val Leu Ala Phe His 
             2740                2745                2750
Tyr Leu His Ala Gly Leu Cys Gly Leu Gln Gly Leu Ala Val Leu Leu 
         2755                2760                2765
Leu Phe Cys Val Leu Asn Ala Asp Ala Arg Ala Ala Trp Thr Pro Ala 
     2770                2775                2780
Cys Leu Gly Lys Lys Ala Ala Pro Glu Glu Thr Arg Pro Ala Pro Gly 
 2785                2790                2795                2800
Pro Gly Ser Gly Ala Tyr Asn Asn Thr Ala Leu Phe Glu Glu Ser Gly 
                 2805                2810                2815
Leu Ile Arg Ile Thr Leu Gly Ala Ser Thr Val Ser Ser Val Ser Ser 
             2820                2825                2830
Ala Arg Ser Gly Arg Ala Gln Asp Gln Asp Ser Gln Arg Gly Arg Ser 
         2835                2840                2845
Tyr Leu Arg Asp Asn Val Leu Val Arg His Gly Ser Thr Ala Glu His 
     2850                2855                2860
Ala Glu His Ser Leu Gln Ala His Ala Gly Pro Thr Asp Leu Asp Val 
 2865                2870                2875                2880
Ala Met Phe His Arg Asp Ala Gly Ala Asp Ser Asp Ser Asp Ser Asp 
                 2885                2890                2895
Leu Ser Leu Glu Glu Glu Arg Ser Leu Ser Ile Pro Ser Ser Glu Ser 
             2900                2905                2910
Glu Asp Asn Gly Arg Thr Arg Gly Arg Phe Gln Arg Pro Leu Arg Arg 
         2915                2920                2925
Ala Ala Gln Ser Glu Arg Leu Leu Ala His Pro Lys Asp Val Asp Gly 
     2930                2935                2940
Asn Asp Leu Leu Ser Tyr Trp Pro Ala Leu Gly Glu Cys Glu Ala Ala 
 2945                2950                2955                2960
Pro Cys Ala Leu Gln Ala Trp Gly Ser Glu Arg Arg Leu Gly Leu Asp 
                 2965                2970                2975
Ser Asn Lys Asp Ala Ala Asn Asn Asn Gln Pro Glu Leu Ala Leu Thr 
             2980                2985                2990
Ser Gly Asp Glu Thr Ser Leu Gly Arg Ala Gln Arg Gln Arg Lys Gly 
         2995                3000                3005
Ile Leu Lys Asn Arg Leu Gln Tyr Pro Leu Val Pro Gln Thr Arg Gly 
     3010                3015                3020
Thr Pro Glu Leu Ser Trp Cys Arg Ala Ala Thr Leu Gly His Arg Ala 
 3025                3030                3035                3040
Val Pro Ala Ala Ser Tyr Gly Arg Ile Tyr Ala Gly Gly Gly Thr Gly 
                 3045                3050                3055
Ser Leu Ser Gln Pro Ala Ser Arg Tyr Ser Ser Arg Glu Gln Leu Asp 
             3060                3065                3070
Leu Leu Leu Arg Arg Gln Leu Ser Arg Glu Arg Leu Glu Glu Val Pro 
         3075                3080                3085
Val Pro Ala Pro Val Leu His Pro Leu Ser Arg Pro Gly Ser Gln Glu 
     3090                3095                3100
Arg Leu Asp Thr Ala Pro Ala Arg Leu Glu Pro Arg Asp Arg Gly Ser 
 3105                3110                3115                3120
Thr Leu Pro Arg Arg Gln Pro Pro Arg Asp Tyr Pro Gly Thr Met Ala 
                 3125                3130                3135
Gly Arg Phe Gly Ser Arg Asp Ala Leu Asp Leu Gly Ala Pro Arg Glu 
             3140                3145                3150
Trp Leu Ser Thr Leu Pro Pro Pro Arg Arg Asn Arg Asp Leu Asp Pro 
         3155                3160                3165
Gln His Pro Pro Leu Pro Leu Ser Pro Gln Arg Pro Leu Ser Arg Asp 
     3170                3175                3180
Pro Leu Leu Pro Ser Arg Pro Leu Asp Ser Leu Ser Arg Ile Ser Asn 
 3185                3190                3195                3200
Ser Arg Glu Arg Leu Asp Gln Val Pro Ser Arg His Pro Ser Arg Glu 
                 3205                3210                3215
Ala Leu Gly Pro Ala Pro Gln Leu Leu Arg Ala Arg Glu Asp Pro Ala 
             3220                3225                3230
Ser Gly Pro Ser His Gly Pro Ser Thr Glu Gln Leu Asp Ile Leu Ser 
         3235                3240                3245
Ser Ile Leu Ala Ser Phe Asn Ser Ser Ala Leu Ser Ser Val Gln Ser 
     3250                3255                3260
Ser Ser Thr Pro Ser Gly Pro His Thr Thr Ala Thr Pro Ser Ala Thr 
 3265                3270                3275                3280
Ala Ser Ala Leu Gly Pro Ser Thr Pro Arg Ser Ala Thr Ser His Ser 
                 3285                3290                3295
Ile Ser Glu Leu Ser Pro Asp Ser Glu Val Pro Arg Ser Glu Gly His 
             3300                3305                3310
Ser 
         3315



<210> 213
<211> 5832
<212> DNA
<213> Homo sapiens
<308> AB011536
<400> 213

gccctgccc  cctcacgca  actgccggg  cctctggca  accttttct  gcacctgcc  60
gccaggtta  tacggccca  gctgtgtgg  tgcctgcct  ctgaacccc  gtcagaacc  120
gggatcatg  cggcacctg  caggagccc  ccatggcta  acctgtgac  gtgtgggtg  180
ctatttcgg  caccactgt  agcacagga  ggaccagca  tgcccacgg  gctggtggg  240
gagcccaac  tgtggcccc  gcaactgtg  tgttcacaa  ggttttgat  ccaactgca  300
caagacaaa  gggcagtgt  actgcaagg  gttccacta  cgaccgcgg  gcagtgact  360
ttgcctccc  tgtgactgc  accctgtgg  ctccacctc  cgctcatgt  caccccaca  420
cgggcagtg  ccctgtcgc  caggagccc  tggccgcca  tgcaacagc  gtgacagtc  480
cttcgcaga  gtgacagcc  gcggctgcc  ggtgctcta  gatgcctgc  ctaagtccc  540
gagatctgg  gtgtggtgg  cccagacaa  gtttggcgt  ctggccaca  tgccctgtc  600
ccggggggc  ctgggattg  ggggtgcag  tgctgctgt  cggctgtgt  atgaggccc  660
gggttggct  gagcccgac  tcttcaact  tacctcccc  gcctttcga  agctcagtc  720
gctgctgga  ggcctagag  tgaacaaga  ggcactgga  accatggag  ccaagaagc  780
ggctcagcg  ctacgggag  tgactggcc  cactgacca  tattttagc  aagatgttc  840
agtcactgc  cgcctgctg  cccacctgc  ggccttcga  agccatcag  agggcttcg  900
gctgacagc  acacaggat  cccacttca  tgagaatct  ctgtgggcc  gctctgcac  960
gcttgcccc  gagacaggg  acttgtggg  ggcgctggg  cagcgggcc  ctgggggct  1020
cccaggcag  gcgggactg  tgaggcacc  ggaggagta  gcagccaca  tcgcaagga  1080
tatggaact  acatacctg  atcccatgg  gctggtgac  cctaatatc  tgctcagca  1140
tgaccgcat  gagcacccc  gttctcccc  gggggcccg  cgctaccct  gctaccata  1200
caacctctt  cgaggccag  atgcctggg  tcctcacac  catgtgctg  tgccttccc  1260
gtccccacg  ccatcccca  ctgaagttc  gcccacaag  agcagcata  aaaactcca  1320
cacctcaag  gtggtcccc  caccagccc  gccagagcc  gagcctggg  tctccatta  1380
cattctcct  gtttaccgc  ccttagggg  actgctccc  gcccagttc  aggcagaac  1440
ccgaggtgc  aggcttcct  agaaccccg  catgaactc  ccggtggtc  gcgtggctg  1500
gttccacgg  cgcaacttc  taaggggaa  cctggagtc  cccatcagc  tagagtttc  1560
cctgctaca  acagcgaat  ggagcaagg  gatctgtgt  cagtgggac  cacctggcc  1620
ggcggagca  catggtgtg  ggacagcac  ggactgcga  ctggtgcac  ggaatgggt  1680
ccacgcacg  tgtcgctgc  gccggacag  gacctttgg  gtcctcatg  atgcctctc  1740
ccgtgagag  ctggagggc  acctggagc  gctggctgt  ttcacccac  tggtcgtgg  1800
tgtgtctgt  gctgcgctg  tgctgactg  agccatcct  ctgagcctg  gcagcctca  1860
gtccaatgt  cgtgggatc  atgccaatg  ggcagccgc  ctgggggtg  cagagctcc  1920
cttcctgct  gggattcac  ggacccaca  tcagctggt  tgcactgca  tcgccatcc  1980
cctgcacta  ttcttcctc  gcaccttcg  gtggctctt  gtgcagggg  tgcacctct  2040
ccgcatgca  gttgagcca  gcaacgtgg  ccgcggcgc  atgcgcttc  accatgccc  2100
gggctgggg  gtccctgct  tgctgctgg  ccttgctgt  ggcctggac  ctgagggct  2160
tgggaaccc  gacttctgc  ggatctcag  ccacgagcc  ctcatctgg  gctttgctg  2220
ccctgttgt  ctggtcata  tgatgaacg  gaccatgtt  ctcctcgct  cccgcacat  2280
ctgctccac  gggcagagg  aggccaaga  gacctctgc  ctgaccctt  gcagctcct  2340
cctgctgct  ctgctggtc  gtgcctcct  gctctttgg  ctcctggca  tcaaccaca  2400
catcctagc  ttccactac  tccatgctg  actctgcgg  ctccagggc  tggcggtgc  2460
gctgctctt  tgtgtccta  atgcagatg  tcgggctgc  tggatgcca  cctgtctgg  2520
caggaaggc  gcgcctgag  aggcaaggc  agcacctgg  ctgggacct  gggcctaca  2580
caacacggc  ctctttgag  agagtggcc  catccgcat  actctgggc  cctccaccg  2640
ctcctctgt  agcagtgcc  gctccggcc  gacccagga  caggacagc  agcggggcc  2700
cagctacct  agggacaat  tcctggttc  acatggctc  gccgctgac  acactgacc  2760
cagcctcca  gctcatgct  gccccactg  cctggacgt  gccatgttc  atcgagatg  2820
tggcgcaga  tccgactct  acagtgacc  gtccttgga  gaggagagg  gtctctcca  2880
tccatcttc  gaaagcgag  acaatggcc  gacgcgggg  cgcttccaa  ggccactct  2940
ccgagcagc  cagagtgag  ggctcctca  ccaccccaa  gatgtggat  gcaatgacc  3000
cctgtccta  tggccagcc  tgggggagt  cgaggcagc  ccctgtgct  tgcagactt  3060
gggctctga  aggcgcctg  ggctggaca  cagcaagga  gcagctaac  acaaccagc  3120
agacccggc  ctgaccagt  gggatgaga  ttctctggg  cgggcccag  gccagagga  3180
aggcatcct  aagaaccgg  tgcaatacc  actggtgcc  cagacccga  gtgcccctg  3240
gctgtcctg  tgccgtgca  ccaccttgg  ccaccgtgc  gtgccagct  cctcttacg  3300
tcgcatcta  gctggcggg  gcacgggca  cctttcaca  ccagccagc  gctactctt  3360
tagagaaca  ctggacctg  tcctccggc  gcaactgag  cgtgagcga  tagaggaag  3420
ccctgcccc  gttctacgt  ccctgagcc  gccagggtc  caggaatgc  tggatgctg  3480
accaggccg  ctggagccc  aagatcggg  cagcaccct  ccacggagg  agccacctc  3540
ggactaccc  ggcgccatg  ctggccgct  cgggtcacg  gatgcgctc  acttagggg  3600
acctcgaga  tggttgagc  cgctgcctc  gccccgccg  acccgggac  ttgacccac  3660
gcccccacc  ctgcccctg  ctccccagc  gcaactctc  agggacccc  tcttgccat  3720
ccggccgct  gactctctg  ctaggagct  gaactctcg  gagcagctg  accaggtgc  3780
tagccggca  ccctcacga  aagcccttg  gccactccc  cagctgctc  gagctaggg  3840
ggactcggt  agtggcccc  gccatggcc  ctccacaga  cagttggac  ttctttcct  3900
catccttgc  tctttcaac  cctcggccc  ctcctctgt  caatcttca  gcacaccct  3960
gggccctca  accactgcc  caccttctg  cacagcctc  gtgcttggg  cctccacgc  4020
acgttctgc  acgtctcac  gcatctcgg  gctgtcgcc  gactcagaa  ttcccagaa  4080
tgagggtca  tcctgaggg  atgacggcg  ggacgagga  cagctgagg  cgacagagg  4140
tctaggcta  caggagaga  tccaggagt  ggggcagat  ccaaggcag  ctcctgctc  4200
ccagtggtg  gtgccccag  tctacctgg  gtggcaggg  tgaggctcc  tgtgcatct  4260
tgagcatgc  tgtgacagg  gcagagacg  gggactgga  ggagacttt  atacgtttt  4320
tacctttgt  accagagag  tgcttatgt  atttttcag  ttttctgtc  cctgggggg  4380
ttgaggctg  gctgggagg  ggagggaga  agagggaga  atgcagttt  accccattt  4440
ggtcctgag  aaaccctat  ctcatctct  tctccttcc  ggggtggac  cagatgggt  4500
ggacacatg  cttcctccc  ctattccac  cccaagttg  tctgagtat  gtcaggggc  4560
caaagtaca  aattgttct  tgcttttta  tgaatgctc  aaaggccaa  cttctgggg  4620
tgggggttg  tcttggaaa  aggggtcct  tgacttcct  atgggggct  gctcatacc  4680
cccctcctg  tggatgtgt  tgtttatta  gtggagtcc  tgccactta  tgccttatg  4740
cctaggact  atgctgtgg  gtgctggtg  agcagctga  gtcgtgttt  cagagcaag  4800
cttccctgt  tcccacggg  aggggctcg  gcctctagt  agacattcc  gcagagggt  4860
ggtggaggg  tcattcacc  gcccctgca  caagcaaaa  ttgtctgtg  tgccatttg  4920
ttccctgac  ctgccccct  cttgaattg  ttccgaagg  tagggtggg  aggtgagca  4980
agggagcag  aacaaggga  ttcaagacc  agaatgtag  tgccactgc  tcctatgtt  5040
acaggatcc  ccgtggccc  aggcacctg  gctgcagga  gtgactccg  tccactcct  5100
ctttattcc  ttaaaaagg  aaaaatgac  gttacgacc  tgttcacaa  actcttact  5160
ttgctattt  gtctgctgt  cagaactga  gactttaaa  ttttgttac  gtttacaag  5220
ccagattca  aaaatgttt  tactttgtt  acaactcaa  actttgagt  ttacacttt  5280
tttacagta  ataattttt  ttcctttgt  tccaagtga  aggtaggga  agtgggaga  5340
ggacttgga  gacccacct  tgaggaccc  gacctggcc  tcttgaggg  ttttctaac  5400
cccaggtct  ccaggccga  ggtcagcct  gagtcccgt  taacagcag  tccagaaga  5460
cttgagagt  ggcgtcctc  aaccacggg  gagagtggc  gtgcagggc  ggggggtgg  5520
ctgtgcaga  acctcctca  ccaccaccc  atgcatact  ttgggaagc  gcttcctgg  5580
agattagaa  ttctacttc  ctgactgga  ctaaatccc  ccagccagg  cccaaactc  5640
ccttaccga  aaggacccc  gctcttgaa  ggctgagtg  cctgctggg  gtgggaggg  5700
gtctttact  tgtcctagg  ttcgtagat  cccctctct  gggttcccc  cctccagcc  5760
agcggccct  tttcctgtc  gtgtaaatt  ttccgtgaa  ccgcgctct  ttttgggaa  5820
aaacttcta  ag  5832



<210> 214
<211> 2923
<212> PRT
<213> Homo sapiens
<308> XP_042739
<400> 214

Met Arg Ser Pro Ala Thr Gly Val Pro Leu Pro Thr Pro Pro Pro Pro 
  1               5                  10                  15
Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Leu Leu Gly Asp 
             20                  25                  30
Gln Val Gly Pro Cys Arg Ser Leu Gly Ser Arg Gly Arg Gly Ser Ser 
         35                  40                  45
Gly Ala Cys Ala Pro Met Gly Trp Leu Cys Pro Ser Ser Ala Ser Asn 
     50                  55                  60
Leu Trp Leu Tyr Thr Ser Arg Cys Arg Asp Ala Gly Thr Glu Leu Thr 
 65                  70                  75                  80
Gly His Leu Val Pro His His Asp Gly Leu Arg Val Trp Cys Pro Glu 
                 85                  90                  95
Ser Glu Ala His Ile Pro Leu Pro Pro Ala Pro Glu Gly Cys Pro Trp 
             100                105                110
Ser Cys Arg Leu Leu Gly Ile Gly Gly His Leu Ser Pro Gln Gly Lys 
         115                120                125
Leu Thr Leu Pro Glu Glu His Pro Cys Leu Lys Ala Pro Arg Leu Arg 
     130                135                140
Cys Gln Ser Cys Lys Leu Ala Gln Ala Pro Gly Leu Arg Ala Gly Glu 
 145                150                155                160
Arg Ser Pro Glu Glu Ser Leu Gly Gly Arg Arg Lys Arg Asn Val Asn 
                 165                170                175
Thr Ala Pro Gln Phe Gln Pro Pro Ser Tyr Gln Ala Thr Val Pro Glu 
             180                185                190
Asn Gln Pro Ala Gly Thr Pro Val Ala Ser Leu Arg Ala Ile Asp Pro 
         195                200                205
Asp Glu Gly Glu Ala Gly Arg Leu Glu Tyr Thr Met Asp Ala Leu Phe 
     210                215                220
Asp Ser Arg Ser Asn Gln Phe Phe Ser Leu Asp Pro Val Thr Gly Ala 
 225                230                235                240
Val Thr Thr Ala Glu Glu Leu Asp Arg Glu Thr Lys Ser Thr His Val 
                 245                250                255
Phe Arg Val Thr Ala Gln Asp His Gly Met Pro Arg Arg Ser Ala Leu 
             260                265                270
Ala Thr Leu Thr Ile Leu Val Thr Asp Thr Asn Asp His Asp Pro Val 
         275                280                285
Phe Glu Gln Gln Glu Tyr Lys Glu Ser Leu Arg Glu Asn Leu Glu Val 
     290                295                300
Gly Tyr Glu Val Leu Thr Val Arg Ala Thr Asp Gly Asp Ala Pro Pro 
 305                310                315                320
Asn Ala Asn Ile Leu Tyr Arg Leu Leu Glu Gly Ser Gly Gly Ser Pro 
                 325                330                335
Ser Glu Val Phe Glu Ile Asp Pro Arg Ser Gly Val Ile Arg Thr Arg 
             340                345                350
Gly Pro Val Asp Arg Glu Glu Val Glu Ser Tyr Gln Leu Thr Val Glu 
         355                360                365
Ala Ser Asp Gln Gly Arg Asp Pro Gly Pro Arg Ser Thr Thr Ala Ala 
     370                375                380
Val Phe Leu Ser Val Glu Asp Asp Asn Asp Asn Ala Pro Gln Phe Ser 
 385                390                395                400
Glu Lys Arg Tyr Val Val Gln Val Arg Glu Asp Val Thr Pro Gly Ala 
                 405                410                415
Pro Val Leu Arg Val Thr Ala Ser Asp Arg Asp Lys Gly Ser Asn Ala 
             420                425                430
Val Val His Tyr Ser Ile Met Ser Gly Asn Ala Arg Gly Gln Phe Tyr 
         435                440                445
Leu Asp Ala Gln Thr Gly Ala Leu Asp Val Val Ser Pro Leu Asp Tyr 
     450                455                460
Glu Thr Thr Lys Glu Tyr Thr Leu Arg Val Arg Ala Gln Asp Gly Gly 
 465                470                475                480
Arg Pro Pro Leu Ser Asn Val Ser Gly Leu Val Thr Val Gln Val Leu 
                 485                490                495
Asp Ile Asn Asp Asn Ala Pro Ile Phe Val Ser Thr Pro Phe Gln Ala 
             500                505                510
Thr Val Leu Glu Ser Val Pro Leu Gly Tyr Leu Val Leu His Val Gln 
         515                520                525
Ala Ile Asp Ala Asp Ala Gly Asp Asn Ala Arg Leu Glu Tyr Arg Leu 
     530                535                540
Ala Gly Val Gly His Asp Phe Pro Phe Thr Ile Asn Asn Gly Thr Gly 
 545                550                555                560
Trp Ile Ser Val Ala Ala Glu Leu Asp Arg Glu Glu Val Asp Phe Tyr 
                 565                570                575
Ser Phe Gly Val Glu Ala Arg Asp His Gly Thr Pro Ala Leu Thr Ala 
             580                585                590
Ser Ala Ser Val Ser Val Thr Val Leu Asp Val Asn Asp Asn Asn Pro 
         595                600                605
Thr Phe Thr Gln Pro Glu Tyr Thr Val Arg Leu Asn Glu Asp Ala Ala 
     610                615                620
Val Gly Thr Ser Val Val Thr Val Ser Ala Val Asp Arg Asp Ala His 
 625                630                635                640
Ser Val Ile Thr Tyr Gln Ile Thr Ser Gly Asn Thr Arg Asn Arg Phe 
                 645                650                655
Ser Ile Thr Ser Gln Ser Gly Gly Gly Leu Val Ser Leu Ala Leu Pro 
             660                665                670
Leu Asp Tyr Lys Leu Glu Arg Gln Tyr Val Leu Ala Val Thr Ala Ser 
         675                680                685
Asp Gly Thr Arg Gln Asp Thr Ala Gln Ile Val Val Asn Val Thr Asp 
     690                695                700
Ala Asn Thr His Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Asn 
 705                710                715                720
Val Asn Glu Asp Arg Pro Ala Gly Thr Thr Val Val Leu Ile Ser Ala 
                 725                730                735
Thr Asp Glu Asp Thr Gly Glu Asn Ala Arg Ile Thr Tyr Phe Met Glu 
             740                745                750
Asp Ser Ile Pro Gln Phe Arg Ile Asp Ala Asp Thr Gly Ala Val Thr 
         755                760                765
Thr Gln Ala Glu Leu Asp Tyr Glu Asp Gln Val Ser Tyr Thr Leu Ala 
     770                775                780
Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Tyr 
 785                790                795                800
Leu Glu Ile Leu Val Asn Asp Val Asn Asp Asn Ala Pro Gln Phe Leu 
                 805                810                815
Arg Asp Ser Tyr Gln Gly Ser Val Tyr Glu Asp Val Pro Pro Phe Thr 
             820                825                830
Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ser Gly Leu Asn Gly 
         835                840                845
Arg Val Phe Tyr Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe 
     850                855                860
Ile Val Glu Ser Thr Ser Gly Ile Val Arg Thr Leu Arg Arg Leu Asp 
 865                870                875                880
Arg Glu Asn Val Ala Gln Tyr Val Leu Arg Ala Tyr Ala Val Asp Lys 
                 885                890                895
Gly Met Pro Pro Ala Arg Thr Pro Met Glu Val Thr Val Thr Val Leu 
             900                905                910
Asp Val Asn Asp Asn Pro Pro Val Phe Glu Gln Asp Glu Phe Asp Val 
         915                920                925
Phe Val Glu Glu Asn Ser Pro Ile Gly Leu Ala Val Ala Arg Val Thr 
     930                935                940
Ala Thr Asp Pro Asp Glu Gly Thr Asn Ala Gln Ile Met Tyr Gln Ile 
 945                950                955                960
Val Glu Gly Asn Ile Pro Glu Val Phe Gln Leu Asp Ile Phe Ser Gly 
                 965                970                975
Glu Leu Thr Ala Leu Val Asp Leu Asp Tyr Glu Asp Arg Pro Glu Tyr 
             980                985                990
Val Leu Val Ile Gln Ala Thr Ser Ala Pro Leu Val Ser Arg Ala Thr 
         995                1000                1005
Val His Val Arg Leu Leu Asp Arg Asn Asp Asn Pro Pro Val Leu Gly 
     1010                1015                1020
Asn Phe Glu Ile Leu Phe Asn Asn Tyr Val Thr Asn Arg Ser Ser Ser 
 1025                1030                1035                1040
Phe Pro Gly Gly Ala Ile Gly Arg Val Pro Ala His Asp Pro Asp Ile 
                 1045                1050                1055
Ser Asp Ser Leu Thr Tyr Ser Phe Glu Arg Gly Asn Glu Leu Ser Leu 
             1060                1065                1070
Val Leu Leu Asn Ala Ser Thr Gly Glu Leu Lys Leu Ser Arg Ala Leu 
         1075                1080                1085
Asp Asn Asn Arg Pro Leu Glu Ala Ile Met Ser Val Leu Val Ser Asp 
     1090                1095                1100
Gly Val His Ser Val Thr Ala Gln Cys Ala Leu Arg Val Thr Ile Ile 
 1105                1110                1115                1120
Thr Asp Glu Met Leu Thr His Ser Ile Thr Leu Arg Leu Glu Asp Met 
                 1125                1130                1135
Ser Pro Glu Arg Phe Leu Ser Pro Leu Leu Gly Leu Phe Ile Gln Ala 
             1140                1145                1150
Val Ala Ala Thr Leu Ala Thr Pro Pro Asp His Val Val Val Phe Asn 
         1155                1160                1165
Val Gln Arg Asp Thr Asp Ala Pro Gly Gly His Ile Leu Asn Val Ser 
     1170                1175                1180
Leu Ser Val Gly Gln Pro Pro Gly Pro Gly Gly Gly Pro Pro Phe Leu 
 1185                1190                1195                1200
Pro Ser Glu Asp Leu Gln Glu Arg Leu Tyr Leu Asn Arg Ser Leu Leu 
                 1205                1210                1215
Thr Ala Ile Ser Ala Gln Arg Val Leu Pro Phe Asp Asp Asn Ile Cys 
             1220                1225                1230
Leu Arg Glu Pro Cys Glu Asn Tyr Met Arg Cys Val Ser Val Leu Arg 
         1235                1240                1245
Phe Asp Ser Ser Ala Pro Phe Ile Ala Ser Ser Ser Val Leu Phe Arg 
     1250                1255                1260
Pro Ile His Pro Val Gly Gly Leu Arg Cys Arg Cys Pro Pro Gly Phe 
 1265                1270                1275                1280
Thr Gly Asp Tyr Cys Glu Thr Glu Val Asp Leu Cys Tyr Ser Arg Pro 
                 1285                1290                1295
Cys Gly Pro His Gly Arg Cys Arg Ser Arg Glu Gly Gly Tyr Thr Cys 
             1300                1305                1310
Leu Cys Arg Asp Gly Tyr Thr Gly Glu His Cys Glu Val Ser Ala Arg 
         1315                1320                1325
Ser Gly Arg Cys Thr Pro Gly Val Cys Lys Asn Gly Gly Thr Cys Val 
     1330                1335                1340
Asn Leu Leu Val Gly Gly Phe Lys Cys Asp Cys Pro Ser Gly Asp Phe 
 1345                1350                1355                1360
Glu Lys Pro Tyr Cys Gln Val Thr Thr Arg Ser Phe Pro Ala His Ser 
                 1365                1370                1375
Phe Ile Thr Phe Arg Gly Leu Arg Gln Arg Phe His Phe Thr Leu Ala 
             1380                1385                1390
Leu Ser Phe Ala Thr Lys Glu Arg Asp Gly Leu Leu Leu Tyr Asn Gly 
         1395                1400                1405
Arg Phe Asn Glu Lys His Asp Phe Val Ala Leu Glu Val Ile Gln Glu 
     1410                1415                1420
Gln Val Gln Leu Thr Phe Ser Ala Gly Glu Ser Thr Thr Thr Val Ser 
 1425                1430                1435                1440
Pro Phe Val Pro Gly Gly Val Ser Asp Gly Gln Trp His Thr Val Gln 
                 1445                1450                1455
Leu Lys Tyr Tyr Asn Lys Pro Leu Leu Gly Gln Thr Gly Leu Pro Gln 
             1460                1465                1470
Gly Pro Ser Glu Gln Lys Val Ala Val Val Thr Val Asp Gly Cys Asp 
         1475                1480                1485
Thr Gly Val Ala Leu Arg Phe Gly Ser Val Leu Gly Asn Tyr Ser Cys 
     1490                1495                1500
Ala Ala Gln Gly Thr Gln Gly Gly Ser Lys Lys Ser Leu Asp Leu Thr 
 1505                1510                1515                1520
Gly Pro Leu Leu Leu Gly Gly Val Pro Asp Leu Pro Glu Ser Phe Pro 
                 1525                1530                1535
Val Arg Met Arg Gln Phe Val Gly Cys Met Arg Asn Leu Gln Val Asp 
             1540                1545                1550
Ser Arg His Ile Asp Met Ala Asp Phe Ile Ala Asn Asn Gly Thr Val 
         1555                1560                1565
Pro Gly Cys Pro Ala Lys Lys Asn Val Cys Asp Ser Asn Thr Cys His 
     1570                1575                1580
Asn Gly Gly Thr Cys Val Asn Gln Trp Asp Ala Phe Ser Cys Glu Cys 
 1585                1590                1595                1600
Pro Leu Gly Phe Gly Gly Lys Ser Cys Ala Gln Glu Met Ala Asn Pro 
                 1605                1610                1615
Gln His Phe Leu Gly Ser Ser Leu Val Ala Trp His Gly Leu Ser Leu 
             1620                1625                1630
Pro Ile Ser Gln Pro Trp Tyr Leu Ser Leu Met Phe Arg Thr Arg Gln 
         1635                1640                1645
Ala Asp Gly Val Leu Leu Gln Ala Ile Thr Arg Gly Arg Ser Thr Ile 
     1650                1655                1660
Thr Leu Gln Leu Arg Glu Gly His Val Met Leu Ser Val Glu Gly Thr 
 1665                1670                1675                1680
Gly Leu Gln Ala Ser Ser Leu Arg Leu Glu Pro Gly Arg Ala Asn Asp 
                 1685                1690                1695
Gly Asp Trp His His Ala Gln Leu Ala Leu Gly Ala Ser Gly Gly Pro 
             1700                1705                1710
Gly His Ala Ile Leu Ser Phe Asp Tyr Gly Gln Gln Arg Ala Glu Gly 
         1715                1720                1725
Asn Leu Gly Pro Arg Leu His Gly Leu His Leu Ser Asn Ile Thr Val 
     1730                1735                1740
Gly Gly Ile Pro Gly Pro Ala Gly Gly Val Ala Arg Gly Phe Arg Gly 
 1745                1750                1755                1760
Cys Leu Gln Gly Val Arg Val Ser Asp Thr Pro Glu Gly Val Asn Ser 
                 1765                1770                1775
Leu Asp Pro Ser His Gly Glu Ser Ile Asn Val Glu Gln Gly Cys Ser 
             1780                1785                1790
Leu Pro Asp Pro Cys Asp Ser Asn Pro Cys Pro Ala Asn Ser Tyr Cys 
         1795                1800                1805
Ser Asn Asp Trp Asp Ser Tyr Ser Cys Ser Cys Asp Pro Gly Tyr Tyr 
     1810                1815                1820
Gly Asp Asn Cys Thr Asn Val Cys Asp Leu Asn Pro Cys Glu His Gln 
 1825                1830                1835                1840
Ser Val Cys Thr Arg Lys Pro Ser Ala Pro His Gly Tyr Thr Cys Glu 
                 1845                1850                1855
Cys Pro Pro Asn Tyr Leu Gly Pro Tyr Cys Glu Thr Arg Ile Asp Gln 
             1860                1865                1870
Pro Cys Pro Arg Gly Trp Trp Gly His Pro Thr Cys Gly Pro Cys Asn 
         1875                1880                1885
Cys Asp Val Ser Lys Gly Phe Asp Pro Asp Cys Asn Lys Thr Ser Gly 
     1890                1895                1900
Glu Cys His Cys Lys Glu Asn His Tyr Arg Pro Pro Gly Ser Pro Thr 
 1905                1910                1915                1920
Cys Leu Leu Cys Asp Cys Tyr Pro Thr Gly Ser Leu Ser Arg Val Cys 
                 1925                1930                1935
Asp Pro Glu Asp Gly Gln Cys Pro Cys Lys Pro Gly Val Ile Gly Arg 
             1940                1945                1950
Gln Cys Asp Arg Cys Asp Asn Pro Phe Ala Glu Val Thr Thr Asn Gly 
         1955                1960                1965
Cys Glu Val Asn Tyr Asp Ser Cys Pro Arg Ala Ile Glu Ala Gly Ile 
     1970                1975                1980
Trp Trp Pro Arg Thr Arg Phe Gly Leu Pro Ala Ala Ala Pro Cys Pro 
 1985                1990                1995                2000
Lys Gly Ser Phe Gly Thr Ala Val Arg His Cys Asp Glu His Arg Gly 
                 2005                2010                2015
Trp Leu Pro Pro Asn Leu Phe Asn Cys Thr Ser Ile Thr Phe Ser Glu 
             2020                2025                2030
Leu Lys Gly Phe Ala Glu Arg Leu Gln Arg Asn Glu Ser Gly Leu Asp 
         2035                2040                2045
Ser Gly Arg Ser Gln Gln Leu Ala Leu Leu Leu Arg Asn Ala Thr Gln 
     2050                2055                2060
His Thr Ala Gly Tyr Phe Gly Ser Asp Val Lys Val Ala Tyr Gln Leu 
 2065                2070                2075                2080
Ala Thr Arg Leu Leu Ala His Glu Ser Thr Gln Arg Gly Phe Gly Leu 
                 2085                2090                2095
Ser Ala Thr Gln Asp Val His Phe Thr Glu Asn Leu Leu Arg Val Gly 
             2100                2105                2110
Ser Ala Leu Leu Asp Thr Ala Asn Lys Arg His Trp Glu Leu Ile Gln 
         2115                2120                2125
Gln Thr Glu Gly Gly Thr Ala Trp Leu Leu Gln His Tyr Glu Ala Tyr 
     2130                2135                2140
Ala Ser Ala Leu Ala Gln Asn Met Arg His Thr Tyr Leu Ser Pro Phe 
 2145                2150                2155                2160
Thr Ile Val Thr Pro Asn Ile Val Ile Ser Val Val Arg Leu Asp Lys 
                 2165                2170                2175
Gly Asn Phe Ala Gly Ala Lys Leu Pro Arg Tyr Glu Ala Leu Arg Gly 
             2180                2185                2190
Glu Gln Pro Pro Asp Leu Glu Thr Thr Val Ile Leu Pro Glu Ser Val 
         2195                2200                2205
Phe Arg Glu Thr Pro Pro Val Val Arg Pro Ala Gly Pro Gly Glu Ala 
     2210                2215                2220
Gln Glu Pro Glu Glu Leu Ala Arg Arg Gln Arg Arg His Pro Glu Leu 
 2225                2230                2235                2240
Ser Gln Gly Glu Ala Val Ala Ser Val Ile Ile Tyr Arg Thr Leu Ala 
                 2245                2250                2255
Gly Leu Leu Pro His Asn Tyr Asp Pro Asp Lys Arg Ser Leu Arg Val 
             2260                2265                2270
Pro Lys Arg Pro Ile Ile Asn Thr Pro Val Val Ser Ile Ser Val His 
         2275                2280                2285
Asp Asp Glu Glu Leu Leu Pro Arg Ala Leu Asp Lys Pro Val Thr Val 
     2290                2295                2300
Gln Phe Arg Leu Leu Glu Thr Glu Glu Arg Thr Lys Pro Ile Cys Val 
 2305                2310                2315                2320
Phe Trp Asn His Ser Ile Leu Val Ser Gly Thr Gly Gly Trp Ser Ala 
                 2325                2330                2335
Arg Gly Cys Glu Val Val Phe Arg Asn Glu Ser His Val Ser Cys Gln 
             2340                2345                2350
Cys Asn His Met Thr Ser Phe Ala Val Leu Met Asp Val Ser Arg Arg 
         2355                2360                2365
Glu Asn Gly Glu Ile Leu Pro Leu Lys Thr Leu Thr Tyr Val Ala Leu 
     2370                2375                2380
Gly Val Thr Leu Ala Ala Leu Leu Leu Thr Phe Phe Phe Leu Thr Leu 
 2385                2390                2395                2400
Leu Arg Ile Leu Arg Ser Asn Gln His Gly Ile Arg Arg Asn Leu Thr 
                 2405                2410                2415
Ala Ala Leu Gly Leu Ala Gln Leu Val Phe Leu Leu Gly Ile Asn Gln 
             2420                2425                2430
Ala Asp Leu Pro Phe Ala Cys Thr Val Ile Ala Ile Leu Leu His Phe 
         2435                2440                2445
Leu Tyr Leu Cys Thr Phe Ser Trp Ala Leu Leu Glu Ala Leu His Leu 
     2450                2455                2460
Tyr Arg Ala Leu Thr Glu Val Arg Asp Val Asn Thr Gly Pro Met Arg 
 2465                2470                2475                2480
Phe Tyr Tyr Met Leu Gly Trp Gly Val Pro Ala Phe Ile Thr Gly Leu 
                 2485                2490                2495
Ala Val Gly Leu Asp Pro Glu Gly Tyr Gly Asn Pro Asp Phe Cys Trp 
             2500                2505                2510
Leu Ser Ile Tyr Asp Thr Leu Ile Trp Ser Phe Ala Gly Pro Val Ala 
         2515                2520                2525
Phe Ala Val Ser Met Ser Val Phe Leu Tyr Ile Leu Ala Ala Arg Ala 
     2530                2535                2540
Ser Cys Ala Ala Gln Arg Gln Gly Phe Glu Lys Lys Gly Pro Val Ser 
 2545                2550                2555                2560
Gly Leu Gln Pro Ser Phe Ala Val Leu Leu Leu Leu Ser Ala Thr Trp 
                 2565                2570                2575
Leu Leu Ala Leu Leu Ser Val Asn Ser Asp Thr Leu Leu Phe His Tyr 
             2580                2585                2590
Leu Phe Ala Thr Cys Asn Cys Ile Gln Gly Pro Phe Ile Phe Leu Ser 
         2595                2600                2605
Tyr Val Val Leu Ser Lys Glu Val Arg Lys Ala Leu Lys Leu Ala Cys 
     2610                2615                2620
Ser Arg Lys Pro Ser Pro Asp Pro Ala Leu Thr Thr Lys Ser Thr Leu 
 2625                2630                2635                2640
Thr Ser Ser Tyr Asn Cys Pro Ser Pro Tyr Ala Asp Gly Arg Leu Tyr 
                 2645                2650                2655
Gln Pro Tyr Gly Asp Ser Ala Gly Ser Leu His Ser Thr Ser Arg Ser 
             2660                2665                2670
Gly Lys Ser Gln Pro Ser Tyr Ile Pro Phe Leu Leu Arg Glu Glu Ser 
         2675                2680                2685
Ala Leu Asn Pro Gly Gln Gly Pro Pro Gly Leu Gly Asp Pro Gly Ser 
     2690                2695                2700
Leu Phe Leu Glu Gly Gln Asp Gln Gln His Asp Pro Asp Thr Asp Ser 
 2705                2710                2715                2720
Asp Ser Asp Leu Ser Leu Glu Asp Asp Gln Ser Gly Ser Tyr Ala Ser 
                 2725                2730                2735
Thr His Ser Ser Asp Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
             2740                2745                2750
Ala Ala Phe Pro Gly Glu Gln Gly Trp Asp Ser Leu Leu Gly Pro Gly 
         2755                2760                2765
Ala Glu Arg Leu Pro Leu His Ser Thr Pro Lys Asp Gly Gly Pro Gly 
     2770                2775                2780
Pro Gly Lys Ala Pro Trp Pro Gly Asp Phe Gly Thr Thr Ala Lys Glu 
 2785                2790                2795                2800
Ser Ser Gly Asn Gly Ala Pro Glu Glu Arg Leu Arg Glu Asn Gly Asp 
                 2805                2810                2815
Ala Leu Ser Arg Glu Gly Ser Leu Gly Pro Leu Pro Gly Ser Ser Ala 
             2820                2825                2830
Gln Pro His Lys Gly Ile Leu Lys Lys Lys Cys Leu Pro Thr Ile Ser 
         2835                2840                2845
Glu Lys Ser Ser Leu Leu Arg Leu Pro Leu Glu Gln Cys Thr Gly Ser 
     2850                2855                2860
Ser Arg Gly Ser Ser Ala Ser Glu Gly Ser Arg Gly Gly Pro Pro Pro 
 2865                2870                2875                2880
Arg Pro Pro Pro Arg Gln Ser Leu Gln Glu Gln Leu Asn Gly Val Met 
                 2885                2890                2895
Pro Ile Ala Met Ser Ile Lys Ala Gly Thr Val Asp Glu Asp Ser Ser 
             2900                2905                2910
Gly Ser Glu Phe Leu Phe Phe Asn Phe Leu His 
         2915                2920



<210> 215
<211> 2346
<212> DNA
<213> Rattus norvegicus
<308> AB011679
<400> 215

ctcgcatct  tctgcagca  cctccgggg  tacgttcca  cctatcagt  tgagaccag  60
ccagaagaa  aaaaccaaa  atccttaat  atcttcttt  gctcggtac  tacattggg  120
ccatcaaaa  aaaattatt  cagtaaacc  tagccatga  ggaaatcgt  cacatccag  180
ccggacagt  tggcaacca  atcggtgct  agttctggg  ggtgataag  gatgaacac  240
gcatcgacc  caccggcac  taccacgga  acagcgact  gcagctgga  cgaatctct  300
tgtactaca  tgaagctac  ggtggcaag  atgtccctc  agctatctt  gtggatcta  360
aacccggga  tatggactc  gttcgctca  gtccttttg  ccagatctt  agaccggac  420
actttgttt  tggtcagtc  ggggcaggc  acaactggg  taagggtca  tacacagag  480
gagctgagc  ggttgactc  gtcttggat  tggtgcgga  ggaggcgga  agctgtgac  540
gcctgcaag  ctttcagct  acccactcg  tgggtggag  cacgggctc  ggcatgggc  600
ccctgctca  cagcaagat  cgagaagaa  accccgacc  catcatgaa  accttcagc  660
tggtgccct  acccaaagt  tctgacacc  tggttgagc  ctacaacgc  accctgtcc  720
tccaccagt  ggtagagaa  acagatgag  cctactgca  tgacaacga  gctctctac  780
acatctgct  ccgtaccct  aagctcacc  cgccaacct  cggagacct  aaccatctc  840
tctctgcca  catgagcgg  gtcaccacc  gcctccgtt  cccgggcca  ctgaacgcc  900
accttcgga  gctggctgt  aacatggtg  ccttcccgc  tctccactt  ttcatgcct  960
gctttgccc  tctcaccag  cgtggaagc  agcagtacc  ggccctcac  gtgcctgaa  1020
tcacccagc  ggtcttcga  gccaagaac  tgatggccg  ctgtgaccc  cgccacggc  1080
ggtacctca  ggttgcggc  gtcttccgt  gacggatgt  catgaagga  gtagatgag  1140
aaatgctca  cgtgcagaa  aagaatagc  gctacttcg  ggaatggat  cccaacaac  1200
tcaagacgg  tgtctgtga  atcccaccg  gaggcctca  gatggcagt  accttcatc  1260
gaaacagca  ggccatcca  gagctcttc  agcgcatct  tgagcagtt  acggcaatg  1320
tccgtcgga  ggctttcct  cactggtac  cgggtgagg  catggacga  atggagttc  1380
ccgaagctg  gagcaacat  aatgacctc  tctctgagt  tcagcagta  caggacgcc  1440
ccgcagaag  ggaagagga  ttcggagag  aggcagaag  agaggccta  ggcggaagc  1500
ctgcgtcac  tcaggctgc  tagttccct  agctttttt  caactgccc  ttgtttctt  1560
ctgctgcct  tgtcctgtt  ttgttccgt  ttgttttct  attgggggg  aaacggtgc  1620
tggcacgtg  caggcgctc  ataaatatt  ctttgtgga  tgtctcctt  ctctttccg  1680
tctgacatt  tgagcgtta  ccctgtgct  cctcctggt  cccatttct  tattatgac  1740
gtccagtta  tattcttcc  atatattct  caggaacca  cgttcggct  cagacccgg  1800
gtagaaccc  gcccagttc  aagaactca  gagagtagc  accatctta  agcaaagta  1860
cgggtgggg  aaaggtggg  agaggagat  ctacttagg  ggtgggatt  tccagtcag  1920
gccatttag  cacgggaat  gctggggct  tcagtcgat  gggctttct  ttttccctg  1980
ttcatctct  ggcctcagg  gaggtatta  cagtattat  accatttat  tcctagctg  2040
cctgagcca  atctgccat  ggaggtgtc  tcccctgtg  tggttctcc  agggacgtt  2100
tatggggat  tgtgggggc  gggcagcaa  gccttgttc  ctaaatgtc  agaaacact  2160
taattacca  ttccacctg  gtgcctcac  cactcccca  aggggaggt  acatctctg  2220
cccatttcc  tcctgttcc  tggcttggt  attccctac  tttctattt  ctgttaaac  2280
tggcttttt  tttttcata  tgaaaagat  acattgccc  gagagccaa  aataaatgg  2340
aattgg  2346



<210> 216
<211> 444
<212> PRT
<213> Rattus norvegicus
<308> P05218
<400> 216

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
  1               5                  10                  15
Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
             20                  25                  30
Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Asp Arg Ile Ser 
         35                  40                  45
Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Ile 
     50                  55                  60
Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
 65                  70                  75                  80
Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                 85                  90                  95
Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
             100                105                110
Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
         115                120                125
Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
     130                135                140
Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
 145                150                155                160
Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                 165                170                175
Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
             180                185                190
Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
         195                200                205
Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
     210                215                220
Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
 225                230                235                240
Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                 245                250                255
Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
             260                265                270
Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
         275                280                285
Leu Thr Gln Gln Val Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
     290                295                300
Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
 305                310                315                320
Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                 325                330                335
Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
             340                345                350
Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Val Thr Phe Ile 
         355                360                365
Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
     370                375                380
Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
 385                390                395                400
Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                 405                410                415
Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
             420                425                430
Glu Glu Asp Phe Gly Glu Glu Ala Glu Glu Glu Ala 
         435                440



<210> 217
<211> 1667
<212> DNA
<213> Homo sapiens
<308> AF070561
<400> 217

gcacctcgc  gctccagcc  ctggggcgc  ttccaacct  ccagcctgc  acctgcgga  60
aaaaaaaat  acttatttt  ttgccccat  cataccttg  ggcgagcaa  aaaattaaa  120
tttaaccat  agggaaatc  tgcacatcc  ggctggtca  tgtggcaac  agatcggtg  180
caagttctg  gaggtgatc  gtgatgaac  tggcatcga  cccaccggc  cctaccacg  240
ggacagcga  ctgcagctg  accgcatct  tgtgtacta  aatgaagcc  caggtggca  300
atatgttcc  cgtgccatc  tggtggatc  agaacctgg  accatggac  ctgttcgct  360
aggtccttt  ggccagatc  ttagaccag  caactttgt  tttggtcag  ctggggcag  420
taacaactg  gccaaaggc  actacacag  gggcgccga  ctggttgat  ctgtcctgg  480
tgtggtacg  aaggaggca  agagctgtg  ctgcctgca  ggcttccag  tgacccact  540
actgggcgg  ggcacaggc  ctggaatgg  cactctcct  atcagcaag  tccgagaag  600
ataccctga  cgcatcatg  ataccttca  tgtggtgcc  tcacccaaa  tgtctgaca  660
cgtggtcga  ccctacaat  ccaccctct  cgtccatca  ttggtagag  atactgatg  720
gacctattg  attgacaac  aggccctct  tgatatctg  ttccgcact  tgaagctga  780
cacaccaac  tacggggat  tgaaccacc  tgtctcagc  accatgagt  gtgtcacca  840
ctgcctccg  ttccctggc  agctcaatg  tgacctccg  aagttggca  tcaacatgg  900
ccccttccc  cgtctccat  tctttatgc  tggctttgc  cctctcacc  gccgtggaa  960
ccagcagta  cgagctctc  cagtgccgg  actcaccca  caggtcttc  atgccaaga  1020
catgatggc  gcctgtgac  cccgccacg  ccgatacct  accgtggct  ctgtcttcc  1080
tggtcggat  tccatgaag  aggtcgatg  gcagatgct  aacgtgcag  acaagaaca  1140
cagctactt  gtggaatgg  tccccaaca  tgtcaagac  gccgtctgt  acatcccac  1200
tcgtggcct  aagatggca  tcaccttca  tggcaatag  acagccatc  aggagctct  1260
caagcgcat  tcggagcag  tcactgcca  gttccgccg  aaggccttc  tccactggt  1320
cacaggcga  ggcatggac  agatggagt  caccgaggc  gagagcaac  tgaacgacc  1380
cgtctctga  tatcagcag  accaggatg  caccgcaga  gaggaggag  atttcggtg  1440
ggaggccga  gaggaggcc  aaggcagag  ccccatcac  tcaggcttc  cagttccct  1500
agccgtctt  ctcaactgc  cctttcctc  ccctcagaa  ttgtgtttg  tgcctctat  1560
ttgtttttt  ttttttctt  tgggggggg  ctagaacag  gcctggcac  tagtaggcg  1620
tcaataaat  cttgtttgt  gaaaaaaaa  aaaaaaaaa  aaaaaaa  1667



<210> 218
<211> 107
<212> PRT
<213> Homo sapiens
<308> P20071
<400> 218

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
  1               5                  10                  15
Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
             20                  25                  30
Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
         35                  40                  45
Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
     50                  55                  60
Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
 65                  70                  75                  80
Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                 85                  90                  95
Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
             100                105



<210> 219
<211> 616
<212> DNA
<213> Rattus norvegicus
<308> AB012234
<400> 219

ggtccatca  ctcccctcc  tccaccagc  ccaccaagc  ccccaagtc  atcgacgac  60
gtgagatgg  gagtccagt  gatgatgta  tctatcctg  gacaggccg  tccccagca  120
ctggcagca  ccagtctag  ggatggccc  acgacgtgg  tgcaggccc  gcttctcta  180
agaagtcag  aaagctgga  ttctgcagc  ccctctcct  tcagggcag  tccccacgc  240
tggctttca  ccaccaccc  ctgcctgtg  ttgctggag  cagaccagg  agcccccgg  300
ccacagcat  agcactgca  ttcccttcc  cctccatca  tcagcagtc  agcccgtac  360
tcacacacc  aaccatccg  taccaccac  accatgggc  ggactcgct  aaggagttc  420
tacagtttg  gtgctctga  ggctcgggt  aggccaccg  gcagcattc  caacgacag  480
cgcctcctc  gccaaccgg  ttgtcagca  cggatcccg  gacagcaac  ttctgaaca  540
cccacagca  tctcagtcc  ggttcctct  attaagatc  acaaagaaa  aacaaaatt  600
taaaaaaaa  aaaaaa  616



<210> 220
<211> 441
<212> PRT
<213> Rattus norvegicus
<308> P70257
<400> 220

Met Tyr Ser Pro Tyr Cys Leu Thr Gln Asp Glu Phe His Pro Phe Ile 
  1               5                  10                  15
Glu Ala Leu Leu Pro His Val Arg Ala Phe Ser Tyr Thr Trp Phe Asn 
             20                  25                  30
Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg Met 
         35                  40                  45
Ser Lys Asp Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Gly Glu Lys 
     50                  55                  60
Pro Glu Ile Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu Arg 
 65                  70                  75                  80
Lys Asp Ile Arg Pro Glu Phe Arg Glu Asp Phe Val Leu Thr Ile Thr 
                 85                  90                  95
Gly Lys Lys Pro Pro Cys Cys Val Leu Ser Asn Pro Asp Gln Lys Gly 
             100                105                110
Lys Ile Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp Arg 
         115                120                125
Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu Ser 
     130                135                140
Thr Asp Gly Glu Arg Leu Tyr Lys Ser Pro Gln Cys Ser Asn Pro Gly 
 145                150                155                160
Leu Cys Val Gln Pro His His Ile Gly Val Thr Ile Lys Glu Leu Asp 
                 165                170                175
Leu Tyr Leu Ala Tyr Phe Val His Thr Pro Glu Ser Gly Gln Ser Asp 
             180                185                190
Ser Ser Asn Gln Gln Gly Asp Ala Asp Ile Lys Pro Leu Pro Asn Gly 
         195                200                205
His Leu Ser Phe Gln Asp Cys Phe Val Thr Ser Gly Val Trp Asn Val 
     210                215                220
Thr Glu Leu Val Arg Val Ser Gln Thr Pro Val Ala Thr Ala Ser Gly 
 225                230                235                240
Pro Asn Phe Ser Leu Ala Asp Leu Glu Ser Pro Ser Tyr Tyr Asn Ile 
                 245                250                255
Asn Gln Val Thr Leu Gly Arg Arg Ser Ile Thr Ser Pro Pro Ser Thr 
             260                265                270
Ser Ser Thr Lys Arg Pro Lys Ser Ile Asp Asp Ser Glu Met Glu Ser 
         275                280                285
Pro Val Asp Asp Val Phe Tyr Pro Gly Thr Gly Arg Ser Pro Ala Ala 
     290                295                300
Gly Ser Ser Gln Ser Ser Gly Trp Pro Asn Asp Val Asp Ala Gly Pro 
 305                310                315                320
Ala Ser Leu Lys Lys Ser Gly Lys Leu Asp Phe Cys Ser Ala Leu Ser 
                 325                330                335
Ser Gln Gly Ser Ser Pro Arg Met Ala Phe Thr His His Pro Leu Pro 
             340                345                350
Leu Leu Ala Gly Val Arg Pro Gly Ser Pro Arg Ala Thr Ala Ser Ala 
         355                360                365
Leu His Phe Pro Ser Thr Ser Ile Ile Gln Gln Ser Ser Pro Tyr Phe 
     370                375                380
Thr His Pro Thr Ile Arg Tyr His His His His Gly Gln Asp Ser Leu 
 385                390                395                400
Lys Glu Phe Val Gln Phe Val Cys Ser Asp Gly Ser Gly Gln Ala Thr 
                 405                410                415
Gly Gln His Ser Gln Arg Gln Ala Pro Pro Leu Pro Thr Gly Leu Ser 
             420                425                430
Ala Ser Asp Pro Gly Thr Ala Thr Phe 
         435                440



<210> 221
<211> 1486
<212> DNA
<213> Homo sapiens
<308> U18759
<400> 221

ctcaaaatc  ggcgttggg  tttgccggg  gcttcagat  aatggatga  ttccacccg  60
tcatcgagg  actgctgcc  cacgtccgc  ctttctcct  cacctggtt  aacctgcag  120
cgcggaagc  caagtactt  aagaagcat  aaaagcgga  gtcgaagga  gaggagcgg  180
cggtgaagg  cgagctgct  ggcgagaag  ccgagatca  gcagaagtg  gcatcccgg  240
tgctggcca  gctgcgcaa  gacatccgg  ccgagttcc  cgaggactt  gtgctgacc  300
tcacgggca  gaagccccc  tgctgcgtg  tctccaacc  cgaccagaa  ggcaagatc  360
ggcggattg  ctgcctgcg  caggctgac  aggtgtggc  gctggacct  gtcatggtg  420
ttttgttta  ggggatccc  ctggaaagt  ctgatgggg  gcggctcta  aagtcgcct  480
agtgctcga  ccccggcct  tgcgtccag  cacatcaca  tggagtcac  atcaaagaa  540
tggatcttt  tctggctta  tttgtccac  ctccggaat  cggacaatc  gatagttca  600
accagcaag  agatgcgga  atcaaacca  tgcccaacg  gcacttaag  ttccaggac  660
gttttgtga  ttccggggt  tggaatgtg  cggagctgg  gagagtatc  cagactcct  720
ttgcaacag  atcagggcc  aacttctcc  tggcggacc  ggagagtcc  agctactac  780
acatcaacc  ggtgaccct  gggcggcgg  ccatcacct  ccctccttc  accagcacc  840
ccaagcgcc  caagtccat  gatgacagt  agatggaga  ccctgttga  gacgtgttc  900
atcccggga  aggccgttc  ccagcagct  gcagcagcc  gtccagcgg  tggcccaac  960
atgtggatg  aggcccggc  tctctaaag  agtcaggaa  gctggactt  tgcagtgcc  1020
tctcctctc  gggcagctc  ccgcgcatg  ctttcaccc  ccacccgct  cctgtgctt  1080
ctggagtca  accagggag  ccccgggcc  cagcatcag  cctgcactt  ccctccacg  1140
ccatcatcc  gcagtcgag  ccgtatttc  cgcacccga  catccgcta  caccaccac  1200
acgggcagg  ctcactgaa  gagtttgtg  agtttgtgt  ctcggatgg  tcgggccag  1260
ccaccggac  gcattcgca  cgacaggcg  ctcctctgc  aaccggttt  tcagcatcg  1320
accccggga  ggcaacttt  tgaacatcc  acagcagtc  cagtcctgg  tcctctgat  1380
agatcgaca  aagaaacaa  aaaatgaga  gaagaggtt  ctcgaaagg  gggagaaga  1440
ttttgagaa  ggaaaaatc  cccagccca  cccagcccc  ccgaaa  1486



<210> 222
<211> 502
<212> PRT
<213> Homo sapiens
<308> Q14938
<400> 222

Met Tyr Ser Pro Tyr Cys Leu Thr Gln Asp Glu Phe His Pro Phe Ile 
  1               5                  10                  15
Glu Ala Leu Leu Pro His Val Arg Ala Phe Ser Tyr Thr Trp Phe Asn 
             20                  25                  30
Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg Met 
         35                  40                  45
Ser Lys Asp Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Gly Glu Lys 
     50                  55                  60
Pro Glu Ile Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu Arg 
 65                  70                  75                  80
Lys Asp Ile Arg Pro Glu Phe Arg Glu Asp Phe Val Leu Thr Ile Thr 
                 85                  90                  95
Gly Lys Lys Pro Pro Cys Cys Val Leu Ser Asn Pro Asp Gln Lys Gly 
             100                105                110
Lys Ile Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp Arg 
         115                120                125
Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu Ser 
     130                135                140
Thr Asp Gly Glu Arg Leu Tyr Lys Ser Pro Gln Cys Ser Asn Pro Gly 
 145                150                155                160
Leu Cys Val Gln Pro His His Ile Gly Val Thr Ile Lys Glu Leu Asp 
                 165                170                175
Leu Tyr Leu Ala Tyr Phe Val His Thr Pro Glu Ser Gly Gln Ser Asp 
             180                185                190
Ser Ser Asn Gln Gln Gly Asp Ala Asp Ile Lys Pro Leu Pro Asn Gly 
         195                200                205
His Leu Ser Phe Gln Asp Cys Phe Val Thr Ser Gly Val Trp Asn Val 
     210                215                220
Thr Glu Leu Val Arg Val Ser Gln Thr Pro Val Ala Thr Ala Ser Gly 
 225                230                235                240
Pro Asn Phe Ser Leu Ala Asp Leu Glu Ser Pro Ser Tyr Tyr Asn Ile 
                 245                250                255
Asn Gln Val Thr Leu Gly Arg Arg Ser Ile Thr Ser Pro Pro Ser Thr 
             260                265                270
Ser Thr Thr Lys Arg Pro Lys Ser Ile Asp Asp Ser Glu Met Glu Ser 
         275                280                285
Pro Val Asp Asp Val Phe Tyr Pro Gly Thr Gly Arg Ser Pro Ala Ala 
     290                295                300
Gly Ser Ser Gln Ser Ser Gly Trp Pro Asn Asp Val Asp Ala Gly Pro 
 305                310                315                320
Ala Ser Leu Lys Lys Ser Gly Lys Leu Asp Phe Cys Ser Ala Leu Ser 
                 325                330                335
Ser Gln Gly Ser Ser Pro Arg Met Ala Phe Thr His His Pro Leu Pro 
             340                345                350
Val Leu Ala Gly Val Arg Pro Gly Ser Pro Arg Ala Thr Ala Ser Ala 
         355                360                365
Leu His Phe Pro Ser Thr Ser Ile Ile Gln Gln Ser Ser Pro Tyr Phe 
     370                375                380
Thr His Pro Thr Ile Arg Tyr His His His His Gly Gln Asp Ser Leu 
 385                390                395                400
Lys Glu Phe Val Gln Phe Val Cys Ser Asp Gly Ser Gly Gln Ala Thr 
                 405                410                415
Gly Gln Pro Asn Gly Ser Gly Gln Gly Lys Val Pro Gly Ser Phe Leu 
             420                425                430
Leu Pro Pro Pro Pro Pro Val Ala Arg Pro Val Pro Leu Pro Met Pro 
         435                440                445
Asp Ser Lys Ser Thr Ser Thr Ala Pro Asp Gly Ala Ala Leu Thr Pro 
     450                455                460
Pro Ser Pro Ser Phe Ala Thr Thr Gly Ala Ser Ser Ala Asn Arg Phe 
 465                470                475                480
Val Ser Ile Gly Pro Arg Asp Gly Asn Phe Leu Asn Ile Pro Gln Gln 
                 485                490                495
Ser Gln Ser Trp Phe Leu 
             500



<210> 223
<211> 616
<212> DNA
<213> Rattus norvegicus
<308> AB012234
<400> 223

ggtccatca  ctcccctcc  tccaccagc  ccaccaagc  ccccaagtc  atcgacgac  60
gtgagatgg  gagtccagt  gatgatgta  tctatcctg  gacaggccg  tccccagca  120
ctggcagca  ccagtctag  ggatggccc  acgacgtgg  tgcaggccc  gcttctcta  180
agaagtcag  aaagctgga  ttctgcagc  ccctctcct  tcagggcag  tccccacgc  240
tggctttca  ccaccaccc  ctgcctgtg  ttgctggag  cagaccagg  agcccccgg  300
ccacagcat  agcactgca  ttcccttcc  cctccatca  tcagcagtc  agcccgtac  360
tcacacacc  aaccatccg  taccaccac  accatgggc  ggactcgct  aaggagttc  420
tacagtttg  gtgctctga  ggctcgggt  aggccaccg  gcagcattc  caacgacag  480
cgcctcctc  gccaaccgg  ttgtcagca  cggatcccg  gacagcaac  ttctgaaca  540
cccacagca  tctcagtcc  ggttcctct  attaagatc  acaaagaaa  aacaaaatt  600
taaaaaaaa  aaaaaa  616



<210> 224
<211> 441
<212> PRT
<213> Rattus norvegicus
<308> P70257
<400> 224

Met Tyr Ser Pro Tyr Cys Leu Thr Gln Asp Glu Phe His Pro Phe Ile 
  1               5                  10                  15
Glu Ala Leu Leu Pro His Val Arg Ala Phe Ser Tyr Thr Trp Phe Asn 
             20                  25                  30
Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg Met 
         35                  40                  45
Ser Lys Asp Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Gly Glu Lys 
     50                  55                  60
Pro Glu Ile Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu Arg 
 65                  70                  75                  80
Lys Asp Ile Arg Pro Glu Phe Arg Glu Asp Phe Val Leu Thr Ile Thr 
                 85                  90                  95
Gly Lys Lys Pro Pro Cys Cys Val Leu Ser Asn Pro Asp Gln Lys Gly 
             100                105                110
Lys Ile Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp Arg 
         115                120                125
Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu Ser 
     130                135                140
Thr Asp Gly Glu Arg Leu Tyr Lys Ser Pro Gln Cys Ser Asn Pro Gly 
 145                150                155                160
Leu Cys Val Gln Pro His His Ile Gly Val Thr Ile Lys Glu Leu Asp 
                 165                170                175
Leu Tyr Leu Ala Tyr Phe Val His Thr Pro Glu Ser Gly Gln Ser Asp 
             180                185                190
Ser Ser Asn Gln Gln Gly Asp Ala Asp Ile Lys Pro Leu Pro Asn Gly 
         195                200                205
His Leu Ser Phe Gln Asp Cys Phe Val Thr Ser Gly Val Trp Asn Val 
     210                215                220
Thr Glu Leu Val Arg Val Ser Gln Thr Pro Val Ala Thr Ala Ser Gly 
 225                230                235                240
Pro Asn Phe Ser Leu Ala Asp Leu Glu Ser Pro Ser Tyr Tyr Asn Ile 
                 245                250                255
Asn Gln Val Thr Leu Gly Arg Arg Ser Ile Thr Ser Pro Pro Ser Thr 
             260                265                270
Ser Ser Thr Lys Arg Pro Lys Ser Ile Asp Asp Ser Glu Met Glu Ser 
         275                280                285
Pro Val Asp Asp Val Phe Tyr Pro Gly Thr Gly Arg Ser Pro Ala Ala 
     290                295                300
Gly Ser Ser Gln Ser Ser Gly Trp Pro Asn Asp Val Asp Ala Gly Pro 
 305                310                315                320
Ala Ser Leu Lys Lys Ser Gly Lys Leu Asp Phe Cys Ser Ala Leu Ser 
                 325                330                335
Ser Gln Gly Ser Ser Pro Arg Met Ala Phe Thr His His Pro Leu Pro 
             340                345                350
Leu Leu Ala Gly Val Arg Pro Gly Ser Pro Arg Ala Thr Ala Ser Ala 
         355                360                365
Leu His Phe Pro Ser Thr Ser Ile Ile Gln Gln Ser Ser Pro Tyr Phe 
     370                375                380
Thr His Pro Thr Ile Arg Tyr His His His His Gly Gln Asp Ser Leu 
 385                390                395                400
Lys Glu Phe Val Gln Phe Val Cys Ser Asp Gly Ser Gly Gln Ala Thr 
                 405                410                415
Gly Gln His Ser Gln Arg Gln Ala Pro Pro Leu Pro Thr Gly Leu Ser 
             420                425                430
Ala Ser Asp Pro Gly Thr Ala Thr Phe 
         435                440



<210> 225
<211> 1486
<212> DNA
<213> Homo sapiens
<308> U18759
<400> 225

ctcaaaatc  ggcgttggg  tttgccggg  gcttcagat  aatggatga  ttccacccg  60
tcatcgagg  actgctgcc  cacgtccgc  ctttctcct  cacctggtt  aacctgcag  120
cgcggaagc  caagtactt  aagaagcat  aaaagcgga  gtcgaagga  gaggagcgg  180
cggtgaagg  cgagctgct  ggcgagaag  ccgagatca  gcagaagtg  gcatcccgg  240
tgctggcca  gctgcgcaa  gacatccgg  ccgagttcc  cgaggactt  gtgctgacc  300
tcacgggca  gaagccccc  tgctgcgtg  tctccaacc  cgaccagaa  ggcaagatc  360
ggcggattg  ctgcctgcg  caggctgac  aggtgtggc  gctggacct  gtcatggtg  420
ttttgttta  ggggatccc  ctggaaagt  ctgatgggg  gcggctcta  aagtcgcct  480
agtgctcga  ccccggcct  tgcgtccag  cacatcaca  tggagtcac  atcaaagaa  540
tggatcttt  tctggctta  tttgtccac  ctccggaat  cggacaatc  gatagttca  600
accagcaag  agatgcgga  atcaaacca  tgcccaacg  gcacttaag  ttccaggac  660
gttttgtga  ttccggggt  tggaatgtg  cggagctgg  gagagtatc  cagactcct  720
ttgcaacag  atcagggcc  aacttctcc  tggcggacc  ggagagtcc  agctactac  780
acatcaacc  ggtgaccct  gggcggcgg  ccatcacct  ccctccttc  accagcacc  840
ccaagcgcc  caagtccat  gatgacagt  agatggaga  ccctgttga  gacgtgttc  900
atcccggga  aggccgttc  ccagcagct  gcagcagcc  gtccagcgg  tggcccaac  960
atgtggatg  aggcccggc  tctctaaag  agtcaggaa  gctggactt  tgcagtgcc  1020
tctcctctc  gggcagctc  ccgcgcatg  ctttcaccc  ccacccgct  cctgtgctt  1080
ctggagtca  accagggag  ccccgggcc  cagcatcag  cctgcactt  ccctccacg  1140
ccatcatcc  gcagtcgag  ccgtatttc  cgcacccga  catccgcta  caccaccac  1200
acgggcagg  ctcactgaa  gagtttgtg  agtttgtgt  ctcggatgg  tcgggccag  1260
ccaccggac  gcattcgca  cgacaggcg  ctcctctgc  aaccggttt  tcagcatcg  1320
accccggga  ggcaacttt  tgaacatcc  acagcagtc  cagtcctgg  tcctctgat  1380
agatcgaca  aagaaacaa  aaaatgaga  gaagaggtt  ctcgaaagg  gggagaaga  1440
ttttgagaa  ggaaaaatc  cccagccca  cccagcccc  ccgaaa  1486



<210> 226
<211> 502
<212> PRT
<213> Homo sapiens
<308> Q14938
<400> 226

Met Tyr Ser Pro Tyr Cys Leu Thr Gln Asp Glu Phe His Pro Phe Ile 
  1               5                  10                  15
Glu Ala Leu Leu Pro His Val Arg Ala Phe Ser Tyr Thr Trp Phe Asn 
             20                  25                  30
Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg Met 
         35                  40                  45
Ser Lys Asp Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Gly Glu Lys 
     50                  55                  60
Pro Glu Ile Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu Arg 
 65                  70                  75                  80
Lys Asp Ile Arg Pro Glu Phe Arg Glu Asp Phe Val Leu Thr Ile Thr 
                 85                  90                  95
Gly Lys Lys Pro Pro Cys Cys Val Leu Ser Asn Pro Asp Gln Lys Gly 
             100                105                110
Lys Ile Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp Arg 
         115                120                125
Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu Ser 
     130                135                140
Thr Asp Gly Glu Arg Leu Tyr Lys Ser Pro Gln Cys Ser Asn Pro Gly 
 145                150                155                160
Leu Cys Val Gln Pro His His Ile Gly Val Thr Ile Lys Glu Leu Asp 
                 165                170                175
Leu Tyr Leu Ala Tyr Phe Val His Thr Pro Glu Ser Gly Gln Ser Asp 
             180                185                190
Ser Ser Asn Gln Gln Gly Asp Ala Asp Ile Lys Pro Leu Pro Asn Gly 
         195                200                205
His Leu Ser Phe Gln Asp Cys Phe Val Thr Ser Gly Val Trp Asn Val 
     210                215                220
Thr Glu Leu Val Arg Val Ser Gln Thr Pro Val Ala Thr Ala Ser Gly 
 225                230                235                240
Pro Asn Phe Ser Leu Ala Asp Leu Glu Ser Pro Ser Tyr Tyr Asn Ile 
                 245                250                255
Asn Gln Val Thr Leu Gly Arg Arg Ser Ile Thr Ser Pro Pro Ser Thr 
             260                265                270
Ser Thr Thr Lys Arg Pro Lys Ser Ile Asp Asp Ser Glu Met Glu Ser 
         275                280                285
Pro Val Asp Asp Val Phe Tyr Pro Gly Thr Gly Arg Ser Pro Ala Ala 
     290                295                300
Gly Ser Ser Gln Ser Ser Gly Trp Pro Asn Asp Val Asp Ala Gly Pro 
 305                310                315                320
Ala Ser Leu Lys Lys Ser Gly Lys Leu Asp Phe Cys Ser Ala Leu Ser 
                 325                330                335
Ser Gln Gly Ser Ser Pro Arg Met Ala Phe Thr His His Pro Leu Pro 
             340                345                350
Val Leu Ala Gly Val Arg Pro Gly Ser Pro Arg Ala Thr Ala Ser Ala 
         355                360                365
Leu His Phe Pro Ser Thr Ser Ile Ile Gln Gln Ser Ser Pro Tyr Phe 
     370                375                380
Thr His Pro Thr Ile Arg Tyr His His His His Gly Gln Asp Ser Leu 
 385                390                395                400
Lys Glu Phe Val Gln Phe Val Cys Ser Asp Gly Ser Gly Gln Ala Thr 
                 405                410                415
Gly Gln Pro Asn Gly Ser Gly Gln Gly Lys Val Pro Gly Ser Phe Leu 
             420                425                430
Leu Pro Pro Pro Pro Pro Val Ala Arg Pro Val Pro Leu Pro Met Pro 
         435                440                445
Asp Ser Lys Ser Thr Ser Thr Ala Pro Asp Gly Ala Ala Leu Thr Pro 
     450                455                460
Pro Ser Pro Ser Phe Ala Thr Thr Gly Ala Ser Ser Ala Asn Arg Phe 
 465                470                475                480
Val Ser Ile Gly Pro Arg Asp Gly Asn Phe Leu Asn Ile Pro Gln Gln 
                 485                490                495
Ser Gln Ser Trp Phe Leu 
             500



<210> 227
<211> 1408
<212> DNA
<213> Rattus norvegicus
<308> AB013112
<400> 227

gtatctctc  agtcacctc  agagatccg  gtggggcta  tcaggtttt  gtttgtttg  60
ttgtttttg  tttggtttg  ttttaatgt  gtagtgaag  cagggaacc  agcaagcag  120
ccttggtgg  aagtgtacc  ctggcagaa  ccccaagat  ccttctgag  aggacggtg  180
caagaagag  ctcatgcag  ggctggccc  gaagagccg  atagcgaag  agacactct  240
cgagttcct  ggcaccttt  taatgattg  ccttggatg  agctctatt  cccaagcgg  300
cctcagtcg  gaacgtttt  gcgggatca  cactatcaa  attggattt  catcggcag  360
cgtgatggc  ctctatgtg  catttggta  ctctggggg  cacatcaac  cagctgtgt  420
ttttgcaat  tgcgtcttt  gaaggatgg  gtggttcaa  ttcccattt  atgtgggag  480
ccagttttt  ggagccttt  ttggggctg  aacggtctt  ggcatttat  atgatggac  540
catggcctt  gctggcgga  aactgctcg  cgtaggaga  aatgcaacg  cattcattt  600
tgcaacata  ccagctcca  tcatatcca  gccaggtgc  tttgtagac  aagtggtgt  660
taccatgtt  ctccttctg  tcgtctttg  catgtttga  tccagaaac  tgggtgtcc  720
cagaggcct  gagcctgtt  tcattagcc  cctgatcat  gtcctttcc  gttctcccg  780
actcaactc  ggctgtgcc  tgaacccag  tcgagacct  agtcccagg  tcttcactg  840
actggcagg  tgggggttt  aggtcttca  agttggaaa  aacttctgg  ggatacctg  900
cgtgggtcc  atgattggt  ctttcctgg  aggtcttat  tacattctt  ttatccaaa  960
gcatcactc  aagctcgac  cagacatga  ggcagagcc  tctgagaac  acctagaga  1020
acacgagct  agtgtcatc  tgtagtggg  tggccagat  tgcagttac  gttcatcca  1080
ttctttctt  agagaagat  tcacctgtg  gcctatgca  acttggggc  ggggaatct  1140
cctgtctgc  agttttctc  agccaactg  gacaaaaaa  ttacaaagg  atccgtgga  1200
aactccacc  gtcacccct  cccagaata  cactgactg  ttatgatgg  tatttgatg  1260
aagtcctta  tcctaggtg  ttgctaaga  ttttgaaac  tgaccatgt  cttggctgg  1320
tagcctcag  gaccttttt  taccctgta  gaaattgtg  catcaaagg  tctgtcttc  1380
caatctata  atacaacat  ctaaaact  1408



<210> 228
<211> 295
<212> PRT
<213> Rattus norvegicus
<308> BAA33680
<400> 228

Met Pro Ser Glu Lys Asp Gly Ala Lys Lys Ser Leu Met Gln Arg Leu 
  1               5                  10                  15
Ala Leu Lys Ser Arg Ile Ala Lys Glu Thr Leu Ser Glu Phe Leu Gly 
             20                  25                  30
Thr Phe Ile Met Ile Val Leu Gly Cys Ser Ser Ile Ala Gln Ala Val 
         35                  40                  45
Leu Ser Arg Glu Arg Phe Gly Gly Ile Ile Thr Ile Asn Ile Gly Phe 
     50                  55                  60
Ala Ser Ala Val Val Met Ala Leu Tyr Val Thr Phe Gly Ile Ser Gly 
 65                  70                  75                  80
Gly His Ile Asn Pro Ala Val Ser Phe Ala Met Cys Ala Phe Gly Arg 
                 85                  90                  95
Met Glu Trp Phe Lys Phe Pro Phe Tyr Val Gly Ala Gln Phe Leu Gly 
             100                105                110
Ala Phe Val Gly Ala Ala Thr Val Phe Gly Ile Tyr Tyr Asp Gly Leu 
         115                120                125
Met Ala Phe Ala Gly Gly Lys Leu Leu Val Val Gly Glu Asn Ala Thr 
     130                135                140
Ala Phe Ile Phe Ala Thr Tyr Pro Ala Pro Phe Ile Ser Thr Pro Gly 
 145                150                155                160
Ala Phe Val Asp Gln Val Val Ser Thr Met Phe Leu Leu Leu Ile Val 
                 165                170                175
Phe Ala Met Phe Asp Ser Arg Asn Leu Gly Val Pro Arg Gly Leu Glu 
             180                185                190
Pro Val Val Ile Gly Leu Leu Ile Ile Val Leu Ser Cys Ser Leu Gly 
         195                200                205
Leu Asn Ser Gly Cys Ala Met Asn Pro Ala Arg Asp Leu Ser Pro Arg 
     210                215                220
Leu Phe Thr Ala Leu Ala Gly Trp Gly Phe Glu Val Phe Thr Val Gly 
 225                230                235                240
Asn Asn Phe Trp Trp Ile Pro Val Val Gly Pro Met Ile Gly Ala Phe 
                 245                250                255
Leu Gly Gly Leu Ile Tyr Ile Leu Phe Ile Gln Met His His Ser Lys 
             260                265                270
Leu Asp Pro Asp Met Lys Ala Glu Pro Ser Glu Asn Asn Leu Glu Lys 
         275                280                285
His Glu Leu Ser Val Ile Met 
     290                295



<210> 229
<211> 2948
<212> DNA
<213> Homo sapiens
<308> NM_020980
<400> 229

aggtaatga  taatctgtc  ggcacaaaa  ggattgttt  ggggatttc  ggttctaag  60
cgcagattc  aacaaatag  agcgaacag  gaatgacag  tccaccaga  gacgattaa  120
ccacagcct  taattggaa  ggcatttgt  cagtcagag  ctcttacca  acatctcca  180
gaatctgtg  gccattgtc  aaacgtcca  tttcatctg  ctgtgaaag  gaggaccac  240
acaggtagg  attggtaga  acaggagtc  tcagagaag  cccaagatg  agcctgagg  300
agcagaaaa  ggaaaaagc  tcaagcaga  actggtctt  aagagcagc  tagcgaaag  360
aaccctctc  gagttcttg  gcacgttca  cttgattgt  cttggatgt  gctgtgttg  420
ccaagctat  ctcagtcga  gacgttttg  aggggtcat  actatcaat  ttggatttt  480
aatggcagt  gcaatggcc  tttatgtgg  tggcggtgt  tctggtggt  acatcaacc  540
agctgtgtc  ttagcaatg  gtctctttg  acggatgaa  tggttcaaa  tgccatttt  600
tgtgggagc  cagttcttg  gagcctttg  gggggctgc  accgtcttt  gcatttact  660
tgatggact  atgtccttt  ctggtggaa  actgctgat  gtgggagaa  atgcaacag  720
acacatttt  gcaacatac  cagctccgt  tctatctct  gcgaacgca  ttgcagatc  780
agtggtggc  accatgata  tcctcataa  cgtctttgc  atttttgac  ccagaaact  840
gggagcccc  agaggccta  agcccattg  catcggcct  ctgattatt  tcattgctt  900
ctccctggg  ctgaacagt  gctgtgcca  gaacccagc  cgagacctg  gtcccagac  960
tttcactgc  ttggcaggc  gggggtttg  agtcttcag  gctggaaac  acttctggt  1020
gattcctgt  gtgggccct  tggttggtg  tgtcattgg  ggcctcatc  atgttcttg  1080
cattgaaat  caccatcca  agcctgact  agtctttaa  gcagaacaa  ctgaggaca  1140
accagagaa  tatgaactc  gtgtcatca  gtagtggca  gctcagctc  ggatttgca  1200
tcagtttgg  attctcttc  gaaagatgg  atctaagtg  ctgtgttct  gtaagcctg  1260
ggtggaatc  acccagttt  gtctgctag  catatggga  atctaattg  aaaagcatc  1320
gcataaaag  ttggaaaca  tgaccactt  tctaccatt  tcccccacc  cacccccca  1380
aataacgct  actgtcccc  gaaacagcc  tctctcctg  cctgtttat  tcatcctcg  1440
tgggaattc  tgctaggta  gcactaata  ctcggcatc  tgacgatag  cccatttgg  1500
tggtttcag  tgcactatc  gtatgaaat  gtgtcacca  aaccctttt  ttcagtatc  1560
acaaagatt  cattctgag  accaaccaa  ccctaaatt  aaagacaaa  ctatggttt  1620
agtcaacat  ttcatgaat  agggagcta  tgggttaag  ttccagttc  cgctatgct  1680
ctggatttg  ataaatact  atattctcc  aacctagtg  tgtagggag  aagagaatg  1740
agctggaag  cacaagggg  ggacattgt  gcattcaga  actgcagga  acaagatga  1800
tttgagaag  caaatggaa  ttttaatgg  aaccattta  cagattaat  tcttgctct  1860
ctgcatttt  gaggacacc  attaatttc  tggtcttta  tatataata  cctaaaata  1920
cattgtaac  tcagtcatg  aaaatacat  actctgtct  tttagctca  atgtatttt  1980
ctaattgcc  acttgagaa  agacatttg  caagttata  caacgactg  gcttgtcca  2040
tattttaca  atgccctag  agccaaaac  gaaagccac  ggatcctgg  ctagctgaa  2100
cttcagagt  ggaggtctc  aaaaagata  taccttatt  ggcttaaca  ttcacaagg  2160
actttcaca  ccattatct  atttaatcc  cataatgac  atgtgaggc  aatgccaca  2220
tgcccattt  tcagataaa  aaacaaaat  ttagggaag  taagttgag  tgtccaaga  2280
cacactgaa  gttgaatgt  atctaatgc  ttcctctac  tttcagaag  tcagtagct  2340
gctgagaat  tttgccaaa  cttccttgc  agccagaag  ggaattggc  gcttctaga  2400
tatgtacac  tctggacaa  atgttcctc  atcttaaga  acaaagacc  tcattgtct  2460
ggtctattc  cacacttac  gagtacaga  gaaggaaag  ggtagcaat  taatcataa  2520
tttcatttg  tgaaaaaca  tatgagaag  cctcccttc  taagccacc  ctggtcttg  2580
taagtcttg  tcttgcttc  tgccagcac  aaacattac  ttcagggga  ttcctctgg  2640
tcagtcttt  ccccttgaa  ttctctaat  gatgttact  ttgacaaaa  atcgcctat  2700
agttacaag  accagggga  gctctacat  aagggatgc  ccttcagtc  aactgtcaa  2760
aagcccaga  ttcccaaag  cattaggtt  cccaactgc  ttgtgctga  atcagaaca  2820
cagaaatta  atgtgaaat  tttctgatg  cttatgttc  acaatctat  gacatacgg  2880
atttttttt  cttgctttg  agctacctg  atatttcct  tttgaaata  aattgttcg  2940
tcattgtt  2948



<210> 230
<211> 295
<212> PRT
<213> Homo sapiens
<308> O43315
<400> 230

Met Gln Pro Glu Gly Ala Glu Lys Gly Lys Ser Phe Lys Gln Arg Leu 
  1               5                  10                  15
Val Leu Lys Ser Ser Leu Ala Lys Glu Thr Leu Ser Glu Phe Leu Gly 
             20                  25                  30
Thr Phe Ile Leu Ile Val Leu Gly Cys Gly Cys Val Ala Gln Ala Ile 
         35                  40                  45
Leu Ser Arg Gly Arg Phe Gly Gly Val Ile Thr Ile Asn Val Gly Phe 
     50                  55                  60
Ser Met Ala Val Ala Met Ala Ile Tyr Val Ala Gly Gly Val Ser Gly 
 65                  70                  75                  80
Gly His Ile Asn Pro Ala Val Ser Leu Ala Met Cys Leu Phe Gly Arg 
                 85                  90                  95
Met Lys Trp Phe Lys Leu Pro Phe Tyr Val Gly Ala Gln Phe Leu Gly 
             100                105                110
Ala Phe Val Gly Ala Ala Thr Val Phe Gly Ile Tyr Tyr Asp Gly Leu 
         115                120                125
Met Ser Phe Ala Gly Gly Lys Leu Leu Ile Val Gly Glu Asn Ala Thr 
     130                135                140
Ala His Ile Phe Ala Thr Tyr Pro Ala Pro Tyr Leu Ser Leu Ala Asn 
 145                150                155                160
Ala Phe Ala Asp Gln Val Val Ala Thr Met Ile Leu Leu Ile Ile Val 
                 165                170                175
Phe Ala Ile Phe Asp Ser Arg Asn Leu Gly Ala Pro Arg Gly Leu Glu 
             180                185                190
Pro Ile Ala Ile Gly Leu Leu Ile Ile Val Ile Ala Ser Ser Leu Gly 
         195                200                205
Leu Asn Ser Gly Cys Ala Met Asn Pro Ala Arg Asp Leu Ser Pro Arg 
     210                215                220
Leu Phe Thr Ala Leu Ala Gly Trp Gly Phe Glu Val Phe Arg Ala Gly 
 225                230                235                240
Asn Asn Phe Trp Trp Ile Pro Val Val Gly Pro Leu Val Gly Ala Val 
                 245                250                255
Ile Gly Gly Leu Ile Tyr Val Leu Val Ile Glu Ile His His Pro Glu 
             260                265                270
Pro Asp Ser Val Phe Lys Ala Glu Gln Ser Glu Asp Lys Pro Glu Lys 
         275                280                285
Tyr Glu Leu Ser Val Ile Met 
     290                295



<210> 231
<211> 1166
<212> DNA
<213> Rattus norvegicus
<308> AB013454
<400> 231

gactcattg  gggtgccca  catgatgtc  tacagcgag  gattggggg  accggctgt  60
tccccactt  cagtccgtg  gagacacat  gtgcatggg  cagcctttg  ttatgtccc  120
agcccacaa  tcctgcaca  gattcctgg  acaaccacc  atgccatct  cagtctgag  180
ccggtagcc  tcacagagc  cagctgtcc  tatggggag  tcctggaat  tcatgaccc  240
ctccctgcc  agctggccc  ggaagagga  caaaagcca  agcccaggc  gtcccagaa  300
cttgcccag  ttggcacaa  gctcctgaa  gtgccgttg  tgctaggct  cctttacct  360
tttgtctgc  ccctggacg  gctcagctc  gccttccaa  tggccggag  gaaagtggc  420
ggggacatc  tcaaggaca  tgccatcct  tccaaccca  tggcagggc  ggtggtggg  480
atcctggtg  cagttctgg  gcagagctc  agcacctcg  catccatca  tgtcagcat  540
gttccctct  gcttgttgg  ggttttttt  tttttttta  tttatccgc  tttatttat  600
ctgaattta  tcccgtgcc  tgagctttt  tttcttcaa  ttcttctgg  atatctttt  660
cttctgtgc  acctcctct  ctggctttg  aacaatctg  tccttctca  tgaggatca  720
ctcgatgtg  cagggggag  tcatgtatg  gttaatccg  ccgtgagct  tgtaggttc  780
tctgcgcat  ttaggagcc  tgttcacct  gatgtgttc  atgaccaga  agtctacat  840
caaaccctt  agttcagca  tactctctg  atttttaag  atgtgcagc  aaaattcag  900
actcttttt  ggccaccgt  cctgtgtcc  gccccactg  ttggcctgg  cgcacctac  960
gactccacc  ttataccgc  ggaatggca  acactgctt  tttaaagtg  catccttca  1020
atacttggt  gctttgcgg  tatgcatac  cttgatggc  tgggcagtt  cccgggtgt  1080
cttaaagtg  acacgaagg  ttgagcctc  tgacttgca  gatttcgtg  ggttttctg  1140
gtcaaggga  tagcgaacc  ggatcc  1166



<210> 232
<211> 184
<212> PRT
<213> Rattus norvegicus
<308> P24049
<400> 232

Met Val Arg Tyr Ser Leu Asp Pro Glu Asn Pro Thr Lys Ser Cys Lys 
  1               5                  10                  15
Ser Arg Gly Ser Asn Leu Arg Val His Phe Lys Asn Thr Arg Glu Thr 
             20                  25                  30
Ala Gln Ala Ile Lys Gly Met His Ile Arg Lys Ala Thr Lys Tyr Leu 
         35                  40                  45
Lys Asp Val Thr Leu Lys Lys Gln Cys Val Pro Phe Arg Arg Tyr Asn 
     50                  55                  60
Gly Gly Val Gly Arg Cys Ala Gln Ala Lys Gln Trp Gly Trp Thr Gln 
 65                  70                  75                  80
Gly Arg Trp Pro Lys Lys Ser Ala Glu Phe Leu Leu His Met Leu Lys 
                 85                  90                  95
Asn Ala Glu Ser Asn Ala Glu Leu Lys Gly Leu Asp Val Asp Ser Leu 
             100                105                110
Val Ile Glu His Ile Gln Val Asn Lys Ala Pro Lys Met Arg Arg Arg 
         115                120                125
Thr Tyr Arg Ala His Gly Arg Ile Asn Pro Tyr Met Ser Ser Pro Cys 
     130                135                140
His Ile Glu Met Ile Leu Thr Glu Lys Glu Gln Ile Val Pro Lys Pro 
 145                150                155                160
Glu Glu Glu Val Ala Gln Lys Lys Lys Ile Ser Gln Lys Lys Leu Lys 
                 165                170                175
Lys Gln Lys Leu Met Ala Arg Glu 
             180



<210> 233
<211> 770
<212> DNA
<213> Homo sapiens
<308> X53777
<400> 233

aggacacct  tggattaat  atgaaaaca  ctactctct  agcagctgt  cgaatcatc  60
gatatttat  ctgaatgag  tactgtaag  acgtattga  agaattaca  tgtactttc  120
tctaggtga  ctgtgaaaa  ggttcgcta  tcacttgac  cggagaacc  cacgaaatc  180
tgcaaatca  gaggttcca  tcttcgtgt  cactttaag  acactcgtg  aactgctca  240
gccatcaag  gtatgcata  acgaaaagc  acgaagtat  tgaaagatg  cactttaca  300
aaacagtgt  taccattcc  acgttacaa  ggtggagtt  gcaggtgtg  gcaggccaa  360
caatggggc  ggacacaag  tcggtggcc  aaaaagagt  ctgaatttt  gctgcacat  420
cttaaaaac  cagagagta  tgctgaact  aagggttta  atgtagatt  tctggtcat  480
gagcatatc  aagtgaaca  agcacctaa  atgcgccgc  ggacctaca  agctcatgg  540
cggattaac  catacatga  ctctccctg  cacattgag  tgatcctta  ggaaaagga  600
cagattgtt  ctaaaccag  agaggaggt  gcccagaag  aaaagatat  ccagaagaa  660
ctgaagaaa  aaaaactta  ggcacggga  taaattcag  attaaaata  atgtaatta  720
aaagaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  770



<210> 234
<211> 184
<212> PRT
<213> Homo sapiens
<308> P18621
<400> 234

Met Val Arg Tyr Ser Leu Asp Pro Glu Asn Pro Thr Lys Ser Cys Lys 
  1               5                  10                  15
Ser Arg Gly Ser Asn Leu Arg Val His Phe Lys Asn Thr Arg Glu Thr 
             20                  25                  30
Ala Gln Ala Ile Lys Gly Met His Ile Arg Lys Ala Thr Lys Tyr Leu 
         35                  40                  45
Lys Asp Val Thr Leu Gln Lys Gln Cys Val Pro Phe Arg Arg Tyr Asn 
     50                  55                  60
Gly Gly Val Gly Arg Cys Ala Gln Ala Lys Gln Trp Gly Trp Thr Gln 
 65                  70                  75                  80
Gly Arg Trp Pro Lys Lys Ser Ala Glu Phe Leu Leu His Met Leu Lys 
                 85                  90                  95
Asn Ala Glu Ser Asn Ala Glu Leu Lys Gly Leu Asp Val Asp Ser Leu 
             100                105                110
Val Ile Glu His Ile Gln Val Asn Lys Ala Pro Lys Met Arg Arg Arg 
         115                120                125
Thr Tyr Arg Ala His Gly Arg Ile Asn Pro Tyr Met Ser Ser Pro Cys 
     130                135                140
His Ile Glu Met Ile Leu Thr Glu Lys Glu Gln Ile Val Pro Lys Pro 
 145                150                155                160
Glu Glu Glu Val Ala Gln Lys Lys Lys Ile Ser Gln Lys Lys Leu Lys 
                 165                170                175
Lys Gln Lys Leu Met Ala Arg Glu 
             180



<210> 235
<211> 2318
<212> DNA
<213> Rattus norvegicus
<308> AB013732
<400> 235

ggagcggcg  gcggagagg  gtgtggagc  tgtggcttg  gaggaaggc  ctgtccgag  60
gaacgtgat  tgcgcggcc  ctgtgtcct  gccttggaa  tggttcagt  atggttgag  120
tcaagaaga  ctgttgcat  ggtgcgggc  acgtcggcg  acccacatg  agtgtcatt  180
ctcgcatgt  ccctgaaat  agggtaacg  ttgtggatg  caatgaggc  aggatcaat  240
catggaatt  tccaacgct  cctatttat  agcctggac  aaaagaagt  gtcgaatcc  300
gtcgaggga  aaacctctt  ttttctacc  atattgatg  tgccatcag  gaagccgat  360
tagtgttta  ttctgtgaa  acaccaaca  aaacatatg  aatgggaaa  ggccgggcg  420
cagatctga  gtatatcga  gcttgtgct  gccgcattg  gcagaactc  aatgggtac  480
aaattgtga  tgagaaaag  acagtccct  tgcgggcag  ggaaagcat  cgccgcata  540
ttgatgcca  cacaaagcc  aacttgaat  tacaggttc  gtccaatcc  gagttcttg  600
cagagggaa  agccatcaa  gacctaaag  acccagaca  agtcctgat  ggaggggat  660
agaccccag  gggccagag  gctgttcag  cactctgtg  tgtgtacga  cactgggtt  720
ccaaggaaa  gatcctcac  accaacact  ggtcctcag  gctttccaa  ctggcagcc  780
atgcttttc  tgcccagag  atcagcagc  ttaactcca  aagtgctct  tgtgaaagc  840
caggcgccg  tgtggaaga  gtggcaacg  ctatcggga  ggaccaaag  attggaaat  900
agtttctaa  agccagcgt  ggttttggt  ggggctgct  ccaaaaaga  gttctgaat  960
tggtttatc  ctgtgaggc  ctgaatctg  ccgaagtag  tcgttactg  cagcaggtc  1020
tagacatga  tgactacca  aggaggagg  ttgcatcac  gatcataga  agcctgttt  1080
atacagtga  tgataagaa  atagctatc  tggggtttg  gttcaaaaa  gatactggt  1140
ataccaggg  gtcctccag  atctacatt  gcaaatacc  gatggacga  ggtgcgcac  1200
tccacatct  cgaccccaa  gtacccagg  agcagatag  ggtggatct  tctcatcca  1260
gcgtctcag  ggatgacca  gtgtccaga  tggtgacca  ttccaagga  ccatatgaa  1320
catgtgatg  cgcccatgc  ctcgttatc  gcacagagt  ggacatgtt  aaggaactg  1380
attatgaac  gattcataa  agaatgctg  agccagcct  catatttga  ggccggcgt  1440
tcctggatg  gctccacaa  gagctacag  ccattggct  ccagattga  acaattggc  1500
aaaaggtat  ttccaagag  attccatac  ctcctggtg  aattccaaa  tttagtctt  1560
aggatccac  taacaagaa  cccaaagtc  agacgtcgc  cttttgcct  tgatgattt  1620
gtactgcag  gtagccagc  tctgtctga  actaagtgg  aaatgaact  cgtgttttt  1680
tggaaacaa  aatattttt  taatcatca  atttatact  gctatctgg  tgttagcat  1740
tctagtaat  atgagtcta  aataatttt  atatatttt  atattattg  actctcagt  1800
actgaatgg  tggaaaaca  tcatgttgg  ttaaatgtc  gtttttata  ataaaaatg  1860
aaccttgaa  tttttagca  tacaggttg  tacagactg  actgtaata  cacaaggga  1920
aggcagtct  atttcccta  ctgttgtct  tgcttatca  taaatggga  ttcgaagcc  1980
tgaaatcac  gtgctagga  ggctgatga  ggtctctgg  cttttgttt  aatgagatt  2040
tgtcattag  ggttttagt  gtctttgtg  ctcccaaaa  cactctgtc  ttctctcca  2100
gcgtaactc  ggcagtgct  tcttttttg  aaattcagc  tgaggagga  atcagtcta  2160
ggtctagtt  gtcctgcct  ttagcttct  tacctgctt  tcacatttg  acctatgag  2220
caagatatg  ttgttacct  tattttgat  tatttctat  acaattcaa  ttttttcct  2280
taattaaga  aaccaataa  gtctcatgt  taaactgg  2318



<210> 236
<211> 493
<212> PRT
<213> Rattus norvegicus
<308> O70199
<400> 236

Met Val Glu Ile Lys Lys Ile Cys Cys Ile Gly Ala Gly Tyr Val Gly 
  1               5                  10                  15
Gly Pro Thr Cys Ser Val Ile Ala Arg Met Cys Pro Glu Ile Arg Val 
             20                  25                  30
Thr Val Val Asp Val Asn Glu Ala Arg Ile Asn Ala Trp Asn Ser Pro 
         35                  40                  45
Thr Leu Pro Ile Tyr Glu Pro Gly Leu Lys Glu Val Val Glu Ser Cys 
     50                  55                  60
Arg Gly Lys Asn Leu Phe Phe Ser Thr Asn Ile Asp Asp Ala Ile Arg 
 65                  70                  75                  80
Glu Ala Asp Leu Val Phe Ile Ser Val Asn Thr Pro Thr Lys Thr Tyr 
                 85                  90                  95
Gly Met Gly Lys Gly Arg Ala Ala Asp Leu Lys Tyr Ile Glu Ala Cys 
             100                105                110
Ala Arg Arg Ile Val Gln Asn Ser Asn Gly Tyr Lys Ile Val Thr Glu 
         115                120                125
Lys Ser Thr Val Pro Val Arg Ala Ala Glu Ser Ile Arg Arg Ile Phe 
     130                135                140
Asp Ala Asn Thr Lys Pro Asn Leu Asn Leu Gln Val Leu Ser Asn Pro 
 145                150                155                160
Glu Phe Leu Ala Glu Gly Thr Ala Ile Lys Asp Leu Lys Asn Pro Asp 
                 165                170                175
Arg Val Leu Ile Gly Gly Asp Glu Thr Pro Glu Gly Gln Arg Ala Val 
             180                185                190
Gln Ala Leu Cys Ala Val Tyr Glu His Trp Val Pro Lys Glu Lys Ile 
         195                200                205
Leu Thr Thr Asn Thr Trp Ser Ser Glu Leu Ser Lys Leu Ala Ala Asn 
     210                215                220
Ala Phe Leu Ala Gln Arg Ile Ser Ser Ile Asn Ser Ile Ser Ala Leu 
 225                230                235                240
Cys Glu Ser Thr Gly Ala Asp Val Glu Glu Val Ala Thr Ala Ile Gly 
                 245                250                255
Met Asp Gln Arg Ile Gly Asn Lys Phe Leu Lys Ala Ser Val Gly Phe 
             260                265                270
Gly Gly Gly Cys Phe Gln Lys Asp Val Leu Asn Leu Val Tyr Leu Cys 
         275                280                285
Glu Ala Leu Asn Leu Pro Glu Val Ala Arg Tyr Trp Gln Gln Val Ile 
     290                295                300
Asp Met Asn Asp Tyr Gln Arg Arg Arg Phe Ala Ser Arg Ile Ile Asp 
 305                310                315                320
Ser Leu Phe Asn Thr Val Thr Asp Lys Lys Ile Ala Ile Leu Gly Phe 
                 325                330                335
Ala Phe Lys Lys Asp Thr Gly Asp Thr Arg Glu Ser Ser Ser Ile Tyr 
             340                345                350
Ile Ser Lys Tyr Leu Met Asp Glu Gly Ala His Leu His Ile Tyr Asp 
         355                360                365
Pro Lys Val Pro Arg Glu Gln Ile Val Val Asp Leu Ser His Pro Gly 
     370                375                380
Val Ser Ala Asp Asp Gln Val Ser Arg Leu Val Thr Ile Ser Lys Asp 
 385                390                395                400
Pro Tyr Glu Ala Cys Asp Gly Ala His Ala Leu Val Ile Cys Thr Glu 
                 405                410                415
Trp Asp Met Phe Lys Glu Leu Asp Tyr Glu Arg Ile His Lys Arg Met 
             420                425                430
Leu Lys Pro Ala Phe Ile Phe Asp Gly Arg Arg Val Leu Asp Gly Leu 
         435                440                445
His Asn Glu Leu Gln Thr Ile Gly Phe Gln Ile Glu Thr Ile Gly Lys 
     450                455                460
Lys Val Ser Ser Lys Arg Ile Pro Tyr Thr Pro Gly Glu Ile Pro Lys 
 465                470                475                480
Phe Ser Leu Gln Asp Pro Pro Asn Lys Lys Pro Lys Val 
                 485                490



<210> 237
<211> 2355
<212> DNA
<213> Homo sapiens
<308> AJ007702
<400> 237

aattcggca  gaaggcgcc  agagggagc  cagatcgag  gggcgcggg  ggagaagct  60
cggcagcgc  gcccgtagg  aggtgctgt  cgaacgatc  ggataggag  ggtccctgc  120
cttgctgct  ggaagtggt  caatcatgt  tgaaattaa  aagatctgt  gcatcggtg  180
aggctatgt  ggaggaccc  catgtagtg  cattgctca  atgtgtcct  aaatcaggg  240
aacggttgt  gatgtcaat  aatcaagaa  caatgcgtg  aattctcct  cacttccta  300
ttatgagcc  ggactaaaa  aagtggtag  atcctgtcg  ggaaaaaat  ttttttttt  360
taccaatat  gatgatgcc  tcaaagaag  tgatcttgt  tttatttct  tgaatactc  420
aacaaaaac  tatggaatg  ggaaaggcc  ggcagcaga  ctgaagtat  ttgaagctt  480
tgctagacg  attgtgcaa  actcaaatg  gtacaaaat  gtgactgag  aaagcacag  540
tccagtgcg  gcagcagaa  gtatccgtc  catatttga  gcaaacaca  aacccaact  600
gaatttaca  gtgctgtcc  accctgagt  tctggcaga  gggacagcc  tcaaggacc  660
aaagaaccc  gacagagta  tgattggag  ggatgaaac  ccagagggc  agagagctg  720
gcaggccct  tgtgctgta  atgagcact  ggttcccag  gaaaagatc  tcaccacta  780
tacttggtc  tcagagctt  ccaaactgg  agcaaatgc  tttcttgcc  agagaataa  840
cagcattaa  tccataagt  ctctgtgtg  agcaacagg  gctgatgta  aagaggtag  900
aacagcgat  ggaatggac  agagaattg  aaacaagtt  ctaaaagcc  gtgttgggt  960
tggtgggag  tgcttccaa  aggatgttc  gaatttggt  tatctctgt  aggctctga  1020
tttgccaga  gtagctcgt  attggcagc  ggtcataga  atgaatgac  accagagga  1080
gaggtttgc  tcccggatc  tagatagtc  gtttaatac  gtaactgat  agaagatag  1140
tattttggg  tttgcattc  aaaaggaca  tggtgatac  agagaatct  ctagtatat  1200
tattagcaa  tatttgatg  atgaaggtg  acatctaca  atatatgat  caaaagtac  1260
tagggaaca  atagttgtg  atctttctc  tccaggtgt  tcagaggat  accaagtgt  1320
ccggctcgt  accatttcc  aggatccat  tgaagcatg  gatggtgcc  atgctgttg  1380
tatttgcac  gagtgggac  tgtttaagg  attggatta  gaacgcatt  ataaaaaaa  1440
gctaaagcc  gcctttatc  tcgatggac  gcgtgtcct  gatgggctc  acaatgaac  1500
acaaaccat  ggcttccag  ttgaaacaa  tggcaaaaa  gtgtcttca  agagaattc  1560
atatgctcc  tctggtgaa  ttccgaagt  tagtcttca  gatccacct  acaagaaac  1620
taaagtcta  agattgcca  ttttatttg  gattttttt  tttttttgg  acttcagga  1680
agcaaatat  tatctgcta  taaatggta  atgaaccaa  tgttttttt  tgttttttt  1740
ttgagacag  gtctcactg  tgcccaggc  ggagtgcag  ggtgcaatc  cggctcact  1800
caagctctg  ttcccaggt  cacgccatt  tcctggctc  gcctcccaa  tagctggga  1860
tacaggcac  cgccacagt  cctggctaa  tttttttgt  tttttagta  agacagggt  1920
tcaccatgt  agccaggat  gtctcaatc  cctgacctt  tgaaccacc  gtctcggcc  1980
cccaaagtg  tgggattac  ggtgtgagc  accacgcct  gcccatgaa  caagtgttt  2040
taaggaaac  aaactattt  tttaatcat  agatttata  tagctatat  gatattagc  2100
tatctggta  ttatgaatc  agaattttt  tacatattt  tataatact  ttagctcag  2160
tattggatg  gtgaaagat  atcatgttg  ttttaatag  gtcaatttt  gtaaaataa  2220
aattaaact  caaactctt  actttataa  ttgtccata  gccacactt  aatatcaca  2280
tataaaggg  aggacagtc  tcattcctc  tggttattg  tttgtttgt  attaaagat  2340
tattttgaa  ccatg  2355



<210> 238
<211> 494
<212> PRT
<213> Homo sapiens
<308> O60701
<400> 238

Met Phe Glu Ile Lys Lys Ile Cys Cys Ile Gly Ala Gly Tyr Val Gly 
  1               5                  10                  15
Gly Pro Thr Cys Ser Val Ile Ala His Met Cys Pro Glu Ile Arg Val 
             20                  25                  30
Thr Val Val Asp Val Asn Glu Ser Arg Ile Asn Ala Trp Asn Ser Pro 
         35                  40                  45
Thr Leu Pro Ile Tyr Glu Pro Gly Leu Lys Glu Val Val Glu Ser Cys 
     50                  55                  60
Arg Gly Lys Asn Leu Phe Phe Ser Thr Asn Ile Asp Asp Ala Ile Lys 
 65                  70                  75                  80
Glu Ala Asp Leu Val Phe Ile Ser Val Asn Thr Pro Thr Lys Thr Tyr 
                 85                  90                  95
Gly Met Gly Lys Gly Arg Ala Ala Asp Leu Lys Tyr Ile Glu Ala Cys 
             100                105                110
Ala Arg Arg Ile Val Gln Asn Ser Asn Gly Tyr Lys Ile Val Thr Glu 
         115                120                125
Lys Ser Thr Val Pro Val Arg Ala Ala Glu Ser Ile Arg Arg Ile Phe 
     130                135                140
Asp Ala Asn Thr Lys Pro Asn Leu Asn Leu Gln Val Leu Ser Asn Pro 
 145                150                155                160
Glu Phe Leu Ala Glu Gly Thr Ala Ile Lys Asp Leu Lys Asn Pro Asp 
                 165                170                175
Arg Val Leu Ile Gly Gly Asp Glu Thr Pro Glu Gly Gln Arg Ala Val 
             180                185                190
Gln Ala Leu Cys Ala Val Tyr Glu His Trp Val Pro Arg Glu Lys Ile 
         195                200                205
Leu Thr Thr Asn Thr Trp Ser Ser Glu Leu Ser Lys Leu Ala Ala Asn 
     210                215                220
Ala Phe Leu Ala Gln Arg Ile Ser Ser Ile Asn Ser Ile Ser Ala Leu 
 225                230                235                240
Cys Glu Ala Thr Gly Ala Asp Val Glu Glu Val Ala Thr Ala Ile Gly 
                 245                250                255
Met Asp Gln Arg Ile Gly Asn Lys Phe Leu Lys Ala Ser Val Gly Phe 
             260                265                270
Gly Gly Ser Cys Phe Gln Lys Asp Val Leu Asn Leu Val Tyr Leu Cys 
         275                280                285
Glu Ala Leu Asn Leu Pro Glu Val Ala Arg Tyr Trp Gln Gln Val Ile 
     290                295                300
Asp Met Asn Asp Tyr Gln Arg Arg Arg Phe Ala Ser Arg Ile Ile Asp 
 305                310                315                320
Ser Leu Phe Asn Thr Val Thr Asp Lys Lys Ile Ala Ile Leu Gly Phe 
                 325                330                335
Ala Phe Lys Lys Asp Thr Gly Asp Thr Arg Glu Ser Ser Ser Ile Tyr 
             340                345                350
Ile Ser Lys Tyr Leu Met Asp Glu Gly Ala His Leu His Ile Tyr Asp 
         355                360                365
Pro Lys Val Pro Arg Glu Gln Ile Val Val Asp Leu Ser His Pro Gly 
     370                375                380
Val Ser Glu Asp Asp Gln Val Ser Arg Leu Val Thr Ile Ser Lys Asp 
 385                390                395                400
Pro Tyr Glu Ala Cys Asp Gly Ala His Ala Val Val Ile Cys Thr Glu 
                 405                410                415
Trp Asp Met Phe Lys Glu Leu Asp Tyr Glu Arg Ile His Lys Lys Met 
             420                425                430
Leu Lys Pro Ala Phe Ile Phe Asp Gly Arg Arg Val Leu Asp Gly Leu 
         435                440                445
His Asn Glu Leu Gln Thr Ile Gly Phe Gln Ile Glu Thr Ile Gly Lys 
     450                455                460
Lys Val Ser Ser Lys Arg Ile Pro Tyr Ala Pro Ser Gly Glu Ile Pro 
 465                470                475                480
Lys Phe Ser Leu Gln Asp Pro Pro Asn Lys Lys Pro Lys Val 
                 485                490



<210> 239
<211> 2532
<212> DNA
<213> Rattus norvegicus
<308> AB014722
<400> 239

cccattttg  gtcgtctgg  ttcgggtgg  ggcccggct  caggcggac  cactaatca  60
ggggtcgtc  aagaagcac  gtggagaga  ggaggcagc  gggactacg  ctgcggccg  120
taccggggg  actaccgag  agccgccac  gcatcgaga  cacaagaaa  acaagcatc  180
gagcagcgg  ggcggcagc  gcggcggcg  acgacggaa  cggagccgc  agcgtgggg  240
cgagcgcgg  agcgggagg  gcggggccg  agccgaggc  cgcagcggc  cgcatggtc  300
tgaacgaag  caagcggaa  cctcggagc  gcgcgtgaa  cgggagaaa  gcgatgaag  360
ctatgaggc  gctgccagc  ccaaagcca  ctctggaga  gcctcatca  tcagcatcg  420
ggagaccaa  aaactccga  caaagttgg  gttgaagcc  ttggaagtc  atgctgtta  480
gaaagaggc  ggcaccaag  aggagcccg  ggcagccga  gttatcaac  ccatggcct  540
gcgacagcg  gaagaacta  gggagaagc  ggcagctgc  aaggaaaag  gcttgctga  600
ccaaaaatt  gggaaaata  agacactgg  ggaggatga  ccctggctt  atgacactg  660
agcctggat  gagaggagc  ggcagctac  gaaagagaa  gacttggcg  agaagcggg  720
caagctgct  gaagagatg  accaagagt  tggtgtgag  actttagtg  aggaggagt  780
tgagcagag  cgacaggac  tgtacagcg  ccgggactt  caaggcctc  ccgtggaac  840
tgcaatcga  tcctttcga  aaggggaga  tgtggtcct  actctcaag  acaaagggg  900
tctgcagga  ggggaggat  tgctggtga  tgtgaacat  gtggacaag  agcgagcag  960
caagaacgt  gaacttcgg  agaagaagc  tgactacct  ccctatgtg  aggacgaga  1020
tgtggatga  ttggcacag  aaaaacctc  ctctatcct  gccaaatat  atgaggaac  1080
ggagggcga  cggccacat  ccttccgtt  agagcaggg  ggcatggcc  atggcctga  1140
agaacgaga  ctcgaagaa  tccggacca  gctacggct  caggctcag  ctctgaaca  1200
tgtagggcc  cggcttgcc  ctgagtacc  cagtccgga  gagatggtg  ctttcaaaa  1260
gaccaaacg  agagtgaag  aaatccgaa  gaaggagaa  gaggtaata  tgcgggcag  1320
tgacttgct  ccccttggc  aagaccaga  tcaggacgg  gactttgga  ccaggcttc  1380
gggccgggg  cggcgccga  ttcctgaag  ggaggagga  gcccttgag  atgaagaga  1440
ggaccctgt  gcccagccg  caccatcag  tgacactcg  gtagagaac  tggacatca  1500
tgatgagga  gatgggggg  ctcttccct  ggggccccc  gagctggag  aggacgaag  1560
ggagctgga  ctgcagaag  agctggaga  ggggcgccg  ctgcggcag  tgcagcaac  1620
gcagcagct  cgggacagc  gtgagaagg  gctggagat  gtgaagaaa  tggagtctc  1680
ccaacgtgg  tgggaagag  aagaggatc  tgagcggaa  gggaccatc  tgttcaatg  1740
cacttctga  ttctgtcgc  ctctggggg  aatccccac  tacggatta  ctggcaacc  1800
agaggagca  gaggagctc  tggactttg  aagggatga  gagcgctcg  ccaatggtg  1860
ctctgaatc  gatggcgaa  agaacattg  ctggagcac  gtcaacctg  atgaggaga  1920
gcaacatca  gatttctcc  cttcctcta  caccatcct  gatgaagag  ccattgtga  1980
cagagggct  gcggctgcc  tgctcctgt  tcagaacaa  ggactgttg  agaccacgg  2040
acaaaaggt  gcccgagta  aggctccca  taagtcact  ccttcagca  tgtactgca  2100
cgaggataa  atggccatt  atgacaagt  cagccgacg  gaggagtac  ggggcttca  2160
ccaggactt  aaggagaag  atggctaca  gcccgatgt  aagattgaa  atgtggatg  2220
gacgggcag  aaactgact  ccaaggagg  attccggca  ctgtcccac  gcttccatg  2280
gaagggctc  gggaagatg  agactgagc  gcggatgaa  aagctggat  aggaggcgc  2340
cctaaagaa  atgagttcc  gtgacacgc  cctgggaac  gtggcactg  tccaggaga  2400
gcagaaggc  caaaagaca  cgtacatcg  gctcagtgg  agtggcaag  gcatgaatg  2460
gaacaccat  accaaatga  gcacctccc  gtcccagat  taatgttaa  taaagttcc  2520
gccttattt  ta  2532



<210> 240
<211> 806
<212> PRT
<213> Rattus norvegicus
<308> BAA36584
<400> 240

Met Gly Ser Ser Lys Lys His Arg Gly Glu Lys Glu Ala Ala Gly Thr 
  1               5                  10                  15
Thr Ala Ala Ala Gly Thr Gly Gly Thr Thr Glu Gln Pro Pro Arg His 
             20                  25                  30
Arg Glu His Lys Lys His Lys His Arg Ser Ser Gly Gly Gly Ser Ser 
         35                  40                  45
Gly Gly Glu Arg Arg Lys Arg Ser Arg Glu Arg Gly Ala Glu Arg Gly 
     50                  55                  60
Ser Gly Arg Arg Gly Ala Glu Ala Glu Ala Arg Ser Gly Ala His Gly 
 65                  70                  75                  80
Arg Glu Arg Ser Gln Ala Glu Pro Ser Glu Arg Arg Val Lys Arg Glu 
                 85                  90                  95
Lys Arg Asp Glu Gly Tyr Glu Ala Ala Ala Ser Ser Lys Ala Ser Ser 
             100                105                110
Gly Asp Ala Ser Ser Leu Ser Ile Glu Glu Thr Asn Lys Leu Arg Ala 
         115                120                125
Lys Leu Gly Leu Lys Pro Leu Glu Val Asn Ala Val Lys Lys Glu Ala 
     130                135                140
Gly Thr Lys Glu Glu Pro Val Ala Ala Asp Val Ile Asn Pro Met Ala 
 145                150                155                160
Leu Arg Gln Arg Glu Glu Leu Arg Glu Lys Leu Ala Ala Ala Lys Glu 
                 165                170                175
Lys Arg Leu Leu Asn Gln Lys Leu Gly Lys Ile Lys Thr Leu Gly Glu 
             180                185                190
Asp Asp Pro Trp Leu Asp Asp Thr Ala Ala Trp Ile Glu Arg Ser Arg 
         195                200                205
Gln Leu Gln Lys Glu Lys Asp Leu Ala Glu Lys Arg Ala Lys Leu Leu 
     210                215                220
Glu Glu Met Asp Gln Glu Phe Gly Val Ser Thr Leu Val Glu Glu Glu 
 225                230                235                240
Phe Glu Gln Arg Arg Gln Asp Leu Tyr Ser Ala Arg Asp Leu Gln Gly 
                 245                250                255
Leu Thr Val Glu His Ala Ile Asp Ser Phe Arg Glu Gly Glu Thr Val 
             260                265                270
Val Leu Thr Leu Lys Asp Lys Gly Val Leu Gln Glu Gly Glu Asp Val 
         275                280                285
Leu Val Asn Val Asn Met Val Asp Lys Glu Arg Ala Asp Lys Asn Val 
     290                295                300
Glu Leu Arg Lys Lys Lys Pro Asp Tyr Leu Pro Tyr Val Glu Asp Glu 
 305                310                315                320
Ser Val Asp Asp Leu Ala Gln Gln Lys Pro Arg Ser Ile Leu Ala Lys 
                 325                330                335
Tyr Asp Glu Glu Leu Glu Gly Glu Arg Pro His Ser Phe Arg Leu Glu 
             340                345                350
Gln Gly Gly Met Ala Asp Gly Leu Arg Glu Arg Glu Leu Glu Glu Ile 
         355                360                365
Arg Thr Lys Leu Arg Leu Gln Ala Gln Ser Leu Asn Thr Val Gly Pro 
     370                375                380
Arg Leu Ala Ser Glu Tyr Leu Ser Pro Glu Glu Met Val Thr Phe Lys 
 385                390                395                400
Lys Thr Lys Arg Arg Val Lys Lys Ile Arg Lys Lys Glu Lys Glu Val 
                 405                410                415
Ile Met Arg Ala Asp Asp Leu Leu Pro Leu Gly Glu Asp Gln Thr Gln 
             420                425                430
Asp Gly Asp Phe Gly Ser Arg Leu Arg Gly Arg Gly Arg Arg Arg Val 
         435                440                445
Pro Glu Val Glu Glu Glu Ala Leu Glu Asp Glu Glu Lys Asp Pro Val 
     450                455                460
Ala Gln Pro Pro Pro Ser Asp Asp Thr Arg Val Glu Asn Met Asp Ile 
 465                470                475                480
Ser Asp Glu Glu Asp Gly Gly Ala Leu Pro Ser Gly Pro Pro Glu Leu 
                 485                490                495
Glu Glu Asp Glu Ala Glu Leu Glu Leu Gln Lys Gln Leu Glu Lys Gly 
             500                505                510
Arg Arg Leu Arg Gln Leu Gln Gln Leu Gln Gln Leu Arg Asp Ser Gly 
         515                520                525
Glu Lys Val Leu Glu Ile Val Lys Lys Leu Glu Ser Arg Gln Arg Gly 
     530                535                540
Trp Glu Glu Glu Glu Asp Pro Glu Arg Lys Gly Thr Ile Val Phe Asn 
 545                550                555                560
Ala Thr Ser Glu Phe Cys Arg Thr Leu Gly Glu Ile Pro Thr Tyr Gly 
                 565                570                575
Leu Ala Gly Asn Arg Glu Glu Gln Glu Glu Leu Met Asp Phe Glu Arg 
             580                585                590
Asp Glu Glu Arg Ser Ala Asn Gly Gly Ser Glu Ser Asp Gly Glu Glu 
         595                600                605
Asn Ile Gly Trp Ser Thr Val Asn Leu Asp Glu Glu Lys Gln His Gln 
     610                615                620
Asp Phe Ser Ala Ser Ser Thr Thr Ile Leu Asp Glu Glu Pro Ile Val 
 625                630                635                640
Asn Arg Gly Leu Ala Ala Ala Leu Leu Leu Cys Gln Asn Lys Gly Leu 
                 645                650                655
Leu Glu Thr Thr Val Gln Lys Val Ala Arg Val Lys Ala Pro Asn Lys 
             660                665                670
Ser Leu Pro Ser Ala Val Tyr Cys Ile Glu Asp Lys Met Ala Ile Asp 
         675                680                685
Asp Lys Tyr Ser Arg Arg Glu Glu Tyr Arg Gly Phe Thr Gln Asp Phe 
     690                695                700
Lys Glu Lys Asp Gly Tyr Lys Pro Asp Val Lys Ile Glu Tyr Val Asp 
 705                710                715                720
Glu Thr Gly Arg Lys Leu Thr Pro Lys Glu Ala Phe Arg Gln Leu Ser 
                 725                730                735
His Arg Phe His Gly Lys Gly Ser Gly Lys Met Lys Thr Glu Arg Arg 
             740                745                750
Met Lys Lys Leu Asp Glu Glu Ala Leu Leu Lys Lys Met Ser Ser Ser 
         755                760                765
Asp Thr Pro Leu Gly Thr Val Ala Leu Leu Gln Glu Lys Gln Lys Ala 
     770                775                780
Gln Lys Thr Pro Tyr Ile Val Leu Ser Gly Ser Gly Lys Ser Met Asn 
 785                790                795                800
Ala Asn Thr Ile Thr Lys 
                 805



<210> 241
<211> 506
<212> DNA
<213> Homo sapiens
<308> AI133253
<400> 241

gttgaggca  ggccggggc  ggagggcgc  gtcacttgg  gatggtgtt  gcgttcatg  60
tcttgccgc  gccgctgag  acgatgtag  gggtcttct  agccttctg  ttctcctgg  120
gcagggcca  ggtgcccag  ggcgtgtcg  tggagctca  cttcttcag  agcgcctcc  180
cgtccagct  cttcatccg  cgctctgtc  tcatcttgc  tgagccctt  ccatctccg  240
gggctccat  cagatcgag  acggctact  tgtacacta  tttgccccc  agggcctaa  300
cacaatgcc  aagaatgtg  tctttgtca  tgacaagag  ggctccatg  gtggcagga  360
aatccagca  acccgggaa  ccctaatca  gatcctgga  gacctcagc  ccagagacc  420
gttcaacct  atcgtcttc  gtacagaag  aactcagtg  atgccatca  tggtgccag  480
ctcagccga  aacgtgaac  aggcca  506



<210> 242
<211> 2532
<212> DNA
<213> Rattus norvegicus
<308> AB014722
<400> 242

cccattttg  gtcgtctgg  ttcgggtgg  ggcccggct  caggcggac  cactaatca  60
ggggtcgtc  aagaagcac  gtggagaga  ggaggcagc  gggactacg  ctgcggccg  120
taccggggg  actaccgag  agccgccac  gcatcgaga  cacaagaaa  acaagcatc  180
gagcagcgg  ggcggcagc  gcggcggcg  acgacggaa  cggagccgc  agcgtgggg  240
cgagcgcgg  agcgggagg  gcggggccg  agccgaggc  cgcagcggc  cgcatggtc  300
tgaacgaag  caagcggaa  cctcggagc  gcgcgtgaa  cgggagaaa  gcgatgaag  360
ctatgaggc  gctgccagc  ccaaagcca  ctctggaga  gcctcatca  tcagcatcg  420
ggagaccaa  aaactccga  caaagttgg  gttgaagcc  ttggaagtc  atgctgtta  480
gaaagaggc  ggcaccaag  aggagcccg  ggcagccga  gttatcaac  ccatggcct  540
gcgacagcg  gaagaacta  gggagaagc  ggcagctgc  aaggaaaag  gcttgctga  600
ccaaaaatt  gggaaaata  agacactgg  ggaggatga  ccctggctt  atgacactg  660
agcctggat  gagaggagc  ggcagctac  gaaagagaa  gacttggcg  agaagcggg  720
caagctgct  gaagagatg  accaagagt  tggtgtgag  actttagtg  aggaggagt  780
tgagcagag  cgacaggac  tgtacagcg  ccgggactt  caaggcctc  ccgtggaac  840
tgcaatcga  tcctttcga  aaggggaga  tgtggtcct  actctcaag  acaaagggg  900
tctgcagga  ggggaggat  tgctggtga  tgtgaacat  gtggacaag  agcgagcag  960
caagaacgt  gaacttcgg  agaagaagc  tgactacct  ccctatgtg  aggacgaga  1020
tgtggatga  ttggcacag  aaaaacctc  ctctatcct  gccaaatat  atgaggaac  1080
ggagggcga  cggccacat  ccttccgtt  agagcaggg  ggcatggcc  atggcctga  1140
agaacgaga  ctcgaagaa  tccggacca  gctacggct  caggctcag  ctctgaaca  1200
tgtagggcc  cggcttgcc  ctgagtacc  cagtccgga  gagatggtg  ctttcaaaa  1260
gaccaaacg  agagtgaag  aaatccgaa  gaaggagaa  gaggtaata  tgcgggcag  1320
tgacttgct  ccccttggc  aagaccaga  tcaggacgg  gactttgga  ccaggcttc  1380
gggccgggg  cggcgccga  ttcctgaag  ggaggagga  gcccttgag  atgaagaga  1440
ggaccctgt  gcccagccg  caccatcag  tgacactcg  gtagagaac  tggacatca  1500
tgatgagga  gatgggggg  ctcttccct  ggggccccc  gagctggag  aggacgaag  1560
ggagctgga  ctgcagaag  agctggaga  ggggcgccg  ctgcggcag  tgcagcaac  1620
gcagcagct  cgggacagc  gtgagaagg  gctggagat  gtgaagaaa  tggagtctc  1680
ccaacgtgg  tgggaagag  aagaggatc  tgagcggaa  gggaccatc  tgttcaatg  1740
cacttctga  ttctgtcgc  ctctggggg  aatccccac  tacggatta  ctggcaacc  1800
agaggagca  gaggagctc  tggactttg  aagggatga  gagcgctcg  ccaatggtg  1860
ctctgaatc  gatggcgaa  agaacattg  ctggagcac  gtcaacctg  atgaggaga  1920
gcaacatca  gatttctcc  cttcctcta  caccatcct  gatgaagag  ccattgtga  1980
cagagggct  gcggctgcc  tgctcctgt  tcagaacaa  ggactgttg  agaccacgg  2040
acaaaaggt  gcccgagta  aggctccca  taagtcact  ccttcagca  tgtactgca  2100
cgaggataa  atggccatt  atgacaagt  cagccgacg  gaggagtac  ggggcttca  2160
ccaggactt  aaggagaag  atggctaca  gcccgatgt  aagattgaa  atgtggatg  2220
gacgggcag  aaactgact  ccaaggagg  attccggca  ctgtcccac  gcttccatg  2280
gaagggctc  gggaagatg  agactgagc  gcggatgaa  aagctggat  aggaggcgc  2340
cctaaagaa  atgagttcc  gtgacacgc  cctgggaac  gtggcactg  tccaggaga  2400
gcagaaggc  caaaagaca  cgtacatcg  gctcagtgg  agtggcaag  gcatgaatg  2460
gaacaccat  accaaatga  gcacctccc  gtcccagat  taatgttaa  taaagttcc  2520
gccttattt  ta  2532



<210> 243
<211> 806
<212> PRT
<213> Rattus norvegicus
<308> BAA36584
<400> 243

Met Gly Ser Ser Lys Lys His Arg Gly Glu Lys Glu Ala Ala Gly Thr 
  1               5                  10                  15
Thr Ala Ala Ala Gly Thr Gly Gly Thr Thr Glu Gln Pro Pro Arg His 
             20                  25                  30
Arg Glu His Lys Lys His Lys His Arg Ser Ser Gly Gly Gly Ser Ser 
         35                  40                  45
Gly Gly Glu Arg Arg Lys Arg Ser Arg Glu Arg Gly Ala Glu Arg Gly 
     50                  55                  60
Ser Gly Arg Arg Gly Ala Glu Ala Glu Ala Arg Ser Gly Ala His Gly 
 65                  70                  75                  80
Arg Glu Arg Ser Gln Ala Glu Pro Ser Glu Arg Arg Val Lys Arg Glu 
                 85                  90                  95
Lys Arg Asp Glu Gly Tyr Glu Ala Ala Ala Ser Ser Lys Ala Ser Ser 
             100                105                110
Gly Asp Ala Ser Ser Leu Ser Ile Glu Glu Thr Asn Lys Leu Arg Ala 
         115                120                125
Lys Leu Gly Leu Lys Pro Leu Glu Val Asn Ala Val Lys Lys Glu Ala 
     130                135                140
Gly Thr Lys Glu Glu Pro Val Ala Ala Asp Val Ile Asn Pro Met Ala 
 145                150                155                160
Leu Arg Gln Arg Glu Glu Leu Arg Glu Lys Leu Ala Ala Ala Lys Glu 
                 165                170                175
Lys Arg Leu Leu Asn Gln Lys Leu Gly Lys Ile Lys Thr Leu Gly Glu 
             180                185                190
Asp Asp Pro Trp Leu Asp Asp Thr Ala Ala Trp Ile Glu Arg Ser Arg 
         195                200                205
Gln Leu Gln Lys Glu Lys Asp Leu Ala Glu Lys Arg Ala Lys Leu Leu 
     210                215                220
Glu Glu Met Asp Gln Glu Phe Gly Val Ser Thr Leu Val Glu Glu Glu 
 225                230                235                240
Phe Glu Gln Arg Arg Gln Asp Leu Tyr Ser Ala Arg Asp Leu Gln Gly 
                 245                250                255
Leu Thr Val Glu His Ala Ile Asp Ser Phe Arg Glu Gly Glu Thr Val 
             260                265                270
Val Leu Thr Leu Lys Asp Lys Gly Val Leu Gln Glu Gly Glu Asp Val 
         275                280                285
Leu Val Asn Val Asn Met Val Asp Lys Glu Arg Ala Asp Lys Asn Val 
     290                295                300
Glu Leu Arg Lys Lys Lys Pro Asp Tyr Leu Pro Tyr Val Glu Asp Glu 
 305                310                315                320
Ser Val Asp Asp Leu Ala Gln Gln Lys Pro Arg Ser Ile Leu Ala Lys 
                 325                330                335
Tyr Asp Glu Glu Leu Glu Gly Glu Arg Pro His Ser Phe Arg Leu Glu 
             340                345                350
Gln Gly Gly Met Ala Asp Gly Leu Arg Glu Arg Glu Leu Glu Glu Ile 
         355                360                365
Arg Thr Lys Leu Arg Leu Gln Ala Gln Ser Leu Asn Thr Val Gly Pro 
     370                375                380
Arg Leu Ala Ser Glu Tyr Leu Ser Pro Glu Glu Met Val Thr Phe Lys 
 385                390                395                400
Lys Thr Lys Arg Arg Val Lys Lys Ile Arg Lys Lys Glu Lys Glu Val 
                 405                410                415
Ile Met Arg Ala Asp Asp Leu Leu Pro Leu Gly Glu Asp Gln Thr Gln 
             420                425                430
Asp Gly Asp Phe Gly Ser Arg Leu Arg Gly Arg Gly Arg Arg Arg Val 
         435                440                445
Pro Glu Val Glu Glu Glu Ala Leu Glu Asp Glu Glu Lys Asp Pro Val 
     450                455                460
Ala Gln Pro Pro Pro Ser Asp Asp Thr Arg Val Glu Asn Met Asp Ile 
 465                470                475                480
Ser Asp Glu Glu Asp Gly Gly Ala Leu Pro Ser Gly Pro Pro Glu Leu 
                 485                490                495
Glu Glu Asp Glu Ala Glu Leu Glu Leu Gln Lys Gln Leu Glu Lys Gly 
             500                505                510
Arg Arg Leu Arg Gln Leu Gln Gln Leu Gln Gln Leu Arg Asp Ser Gly 
         515                520                525
Glu Lys Val Leu Glu Ile Val Lys Lys Leu Glu Ser Arg Gln Arg Gly 
     530                535                540
Trp Glu Glu Glu Glu Asp Pro Glu Arg Lys Gly Thr Ile Val Phe Asn 
 545                550                555                560
Ala Thr Ser Glu Phe Cys Arg Thr Leu Gly Glu Ile Pro Thr Tyr Gly 
                 565                570                575
Leu Ala Gly Asn Arg Glu Glu Gln Glu Glu Leu Met Asp Phe Glu Arg 
             580                585                590
Asp Glu Glu Arg Ser Ala Asn Gly Gly Ser Glu Ser Asp Gly Glu Glu 
         595                600                605
Asn Ile Gly Trp Ser Thr Val Asn Leu Asp Glu Glu Lys Gln His Gln 
     610                615                620
Asp Phe Ser Ala Ser Ser Thr Thr Ile Leu Asp Glu Glu Pro Ile Val 
 625                630                635                640
Asn Arg Gly Leu Ala Ala Ala Leu Leu Leu Cys Gln Asn Lys Gly Leu 
                 645                650                655
Leu Glu Thr Thr Val Gln Lys Val Ala Arg Val Lys Ala Pro Asn Lys 
             660                665                670
Ser Leu Pro Ser Ala Val Tyr Cys Ile Glu Asp Lys Met Ala Ile Asp 
         675                680                685
Asp Lys Tyr Ser Arg Arg Glu Glu Tyr Arg Gly Phe Thr Gln Asp Phe 
     690                695                700
Lys Glu Lys Asp Gly Tyr Lys Pro Asp Val Lys Ile Glu Tyr Val Asp 
 705                710                715                720
Glu Thr Gly Arg Lys Leu Thr Pro Lys Glu Ala Phe Arg Gln Leu Ser 
                 725                730                735
His Arg Phe His Gly Lys Gly Ser Gly Lys Met Lys Thr Glu Arg Arg 
             740                745                750
Met Lys Lys Leu Asp Glu Glu Ala Leu Leu Lys Lys Met Ser Ser Ser 
         755                760                765
Asp Thr Pro Leu Gly Thr Val Ala Leu Leu Gln Glu Lys Gln Lys Ala 
     770                775                780
Gln Lys Thr Pro Tyr Ile Val Leu Ser Gly Ser Gly Lys Ser Met Asn 
 785                790                795                800
Ala Asn Thr Ile Thr Lys 
                 805



<210> 244
<211> 506
<212> DNA
<213> Homo sapiens
<308> AI133253
<400> 244

gttgaggca  ggccggggc  ggagggcgc  gtcacttgg  gatggtgtt  gcgttcatg  60
tcttgccgc  gccgctgag  acgatgtag  gggtcttct  agccttctg  ttctcctgg  120
gcagggcca  ggtgcccag  ggcgtgtcg  tggagctca  cttcttcag  agcgcctcc  180
cgtccagct  cttcatccg  cgctctgtc  tcatcttgc  tgagccctt  ccatctccg  240
gggctccat  cagatcgag  acggctact  tgtacacta  tttgccccc  agggcctaa  300
cacaatgcc  aagaatgtg  tctttgtca  tgacaagag  ggctccatg  gtggcagga  360
aatccagca  acccgggaa  ccctaatca  gatcctgga  gacctcagc  ccagagacc  420
gttcaacct  atcgtcttc  gtacagaag  aactcagtg  atgccatca  tggtgccag  480
ctcagccga  aacgtgaac  aggcca  506



<210> 245
<211> 1269
<212> DNA
<213> Rattus norvegicus
<308> AB015191
<400> 245

atgggctct  agtacccaa  gtccctccg  tgctgcctg  ccctgtggg  cttcgggct  60
caggtgact  ttatcctcc  cttctattt  ctcatcggc  aagacccta  ccaggcaga  120
cacaagttc  tggcgatct  tcaagtcat  caggatttg  cccttgtgg  agccttggg  180
ttcggcttc  tgtcctcat  ctttcggag  cacggctgg  gcagtgtgg  cttcagctt  240
ttcatgttg  cccttgggg  acaggggac  atcttgctg  actatttcc  gaattgggt  300
ctcgactgg  acatgatca  gaatccgtt  agtccgttt  tcagcatcc  gagagctac  360
ataagcacc  taccgctgc  gatctcagc  ggcgctgtc  tggggaagg  caacttggt  420
cagctggcc  tgatggtgc  ggtggaagc  atgaccttt  gtgccatca  agtcgctga  480
aagaaggtc  tcagaattg  agaccacat  atcatgatg  acggacacg  gtttggggc  540
tattttggg  tgactgtgg  atggtggct  tccaagtct  tgcccagga  aaggcatga  600
aacgcccag  cagaaaagg  tcagatgac  acgagctcc  gtctgtttg  catgctggg  660
accctcttc  tgtggatat  ctggccaag  atcaactct  ctctcctgg  agggacaaa  720
aaaaagaac  cagtgttca  cacctacta  gccctggca  tcagcacag  gacagccac  780
tccatgtcc  ccctgagtc  ccccaaagg  aagatcaac  tggttcaca  ccacaacgc  840
gtgctggct  ggggtgtgg  tgtcggtgc  ccgagttgc  tgatttctt  tccttggat  900
gctatggtc  tgggcctca  agctgggtt  atctccatc  ggggagcca  gtgtccaca  960
gtgtgtttg  gcgacttgc  gctgaaccc  agtgggatc  actacacct  cggcttgcc  1020
ggcctgctc  gagcactca  ctactactg  ctccatata  tagccgagt  caggccctc  1080
aatctctgg  ttgtcaccc  aacgatcac  gacgtcggg  ctctcagct  tgctatggc  1140
atgggaatg  tgactggac  gctgacagg  tgtctccta  gtgtcaaag  gtggagggc  1200
ccccatgca  tcaagtact  tgatgatca  gctttctgg  agttccccc  cttggctgt  1260
gaattttaa  1269



<210> 246
<211> 422
<212> PRT
<213> Rattus norvegicus
<308> NP_071950
<400> 246

Met Gly Ser Lys Tyr Pro Arg Ser Leu Arg Cys Cys Leu Pro Leu Trp 
  1               5                  10                  15
Ala Phe Gly Leu Gln Val Thr Phe Ile Leu Leu Phe Tyr Phe Leu Ile 
             20                  25                  30
Gly Gln Asp Pro Ile Gln Ala Asp His Lys Phe Met Ala Ile Tyr Gln 
         35                  40                  45
Val Ile Gln Asp Leu Thr Leu Val Ala Ala Leu Gly Phe Gly Phe Leu 
     50                  55                  60
Ser Ser Ser Phe Arg Arg His Gly Trp Ser Ser Val Ala Phe Ser Phe 
 65                  70                  75                  80
Phe Met Leu Ala Leu Gly Val Gln Gly Thr Ile Leu Leu Asp Tyr Phe 
                 85                  90                  95
Leu Asn Trp Val Leu Asp Trp Asn Met Ile Lys Asn Pro Phe Ser Pro 
             100                105                110
Phe Leu Ser Ile Gln Arg Ala Thr Ile Ser Thr Leu Pro Leu Leu Ile 
         115                120                125
Ser Ala Gly Ala Val Leu Gly Lys Val Asn Leu Val Gln Leu Ala Val 
     130                135                140
Met Val Leu Val Glu Ala Met Thr Phe Gly Ala Ile Arg Val Ala Asp 
 145                150                155                160
Lys Lys Val Phe Arg Ile Glu Asp His Ile Ile Met Met Tyr Gly His 
                 165                170                175
Val Phe Gly Ala Tyr Phe Gly Leu Thr Val Ala Trp Trp Leu Ser Lys 
             180                185                190
Ser Leu Pro Arg Arg Arg His Glu Asn Ala Gln Thr Glu Lys Val Gln 
         195                200                205
Met Thr Thr Ser Ser Ser Leu Phe Ala Met Leu Gly Thr Leu Phe Leu 
     210                215                220
Trp Ile Phe Trp Pro Ser Ile Asn Ser Ala Leu Leu Glu Gly Thr Lys 
 225                230                235                240
Lys Lys Asn Ala Val Phe Asn Thr Tyr Tyr Ala Leu Ala Val Ser Thr 
                 245                250                255
Val Thr Ala Thr Ser Met Ser Ala Leu Ser His Pro Lys Gly Lys Ile 
             260                265                270
Asn Met Val His Ile His Asn Ala Val Leu Ala Gly Gly Val Ala Val 
         275                280                285
Gly Ala Pro Ser Cys Leu Ile Ser Ser Pro Trp Ile Ala Met Val Leu 
     290                295                300
Gly Leu Thr Ala Gly Leu Ile Ser Ile Trp Gly Ala Lys Cys Pro Gln 
 305                310                315                320
Val Cys Leu Ser Asp Leu Leu Leu Asn Pro Ser Gly Ile His Tyr Thr 
                 325                330                335
Phe Gly Leu Pro Gly Leu Leu Gly Ala Leu Thr Tyr Tyr Cys Leu His 
             340                345                350
Ile Ile Ala Glu Ser Arg Pro Ser Asn Leu Trp Ile Val Thr Gln Thr 
         355                360                365
Ile Thr Asp Val Gly Ala Leu Ser Phe Ala Met Ala Met Gly Met Val 
     370                375                380
Thr Gly Leu Leu Thr Gly Cys Leu Leu Ser Val Lys Val Trp Arg Ala 
 385                390                395                400
Pro His Ala Val Lys Tyr Phe Asp Asp Gln Ala Phe Trp Glu Phe Pro 
                 405                410                415
His Leu Ala Val Glu Phe 
             420



<210> 247
<211> 1254
<212> DNA
<213> Homo sapiens
<308> S82449
<400> 247

atgagctct  agtacccgc  gtctgtccg  cgctgcctg  ccctctggg  cctaacact  60
gaagcagct  tcattctcc  cttctattt  tttacccac  atgacgctt  cttagagga  120
caaaagggg  tcgtggcat  ctatcaagt  ggccaagat  tgaccgtga  ggcggccat  180
ggcttgggc  tcctcacct  gagtttccg  agacacagc  ggagcagtg  ggccttcaa  240
ctcttcatg  tggcgcttg  tgtgcagtg  gcaatcctg  tggacggct  cctgagcca  300
ttcccttct  ggaaggtgg  catcacact  ttcagtatt  ggctggcca  catgagtgc  360
atgtcggtg  tgatctcag  gggtgctgt  ttggggaag  tcaacttgg  gcagttggt  420
gtgatggtg  tggtggagg  gacagcttt  ggcaccctg  ggatggtca  cagtaatat  480
ttcaacaca  actaccaca  gaacatgat  cacatctac  tgttcgcag  ctattttgg  540
ctgtctgtg  cctggtgcc  gccaaagcc  ctacccgag  gaacggagg  taaagatca  600
acagcaacg  tacccagtt  gtctgccat  ctgggcgcc  tcttcttgt  gatgttctg  660
ccaagtttc  actctgctc  gctgagaag  ccaatcgaa  ggaagaatg  cgtgttcaa  720
acctactat  ctgtagcag  cagtgtggt  acagccatc  cagggtcat  cttggctca  780
ccccaaggg  agatcagca  gacttatgt  cacagtgcg  tgttggcag  aggcgtggc  840
gtgggtacc  cgtgtcacc  gatcccttc  ccgtggctt  ccatggtgc  gggtcttgt  900
gctgggctg  tctccgtcg  gggagccaa  tacctgccg  ggtgttgta  ccgagtgct  960
gggattccc  acagctcca  catgggcta  aacttcagc  tgctgggtc  gcttggaga  1020
atcatctac  ttgtgctgc  ggtgcttga  accgtcgga  ccggcaatg  catgattgg  1080
ttccaggtc  tcctcagca  tggggaact  agcttggcc  tcgtgatag  tctcacgtc  1140
ggtctcctg  caggtttgc  cctaaatct  aaaatatgg  aagcacctc  tgaggctaa  1200
tattttgat  accaagttt  ctggaagtt  cctcatttg  ctgttggat  ttaa  1254



<210> 248
<211> 416
<212> PRT
<213> Homo sapiens
<308> Q9UQ21
<400> 248

Ser Ser Lys Tyr Pro Arg Ser Val Arg Arg Cys Leu Pro Leu Trp Ala 
  1               5                  10                  15
Leu Thr Leu Glu Ala Ala Leu Ile Leu Leu Phe Tyr Phe Phe Thr His 
             20                  25                  30
Tyr Asp Ala Ser Leu Glu Asp Gln Lys Gly Leu Val Ala Ser Tyr Gln 
         35                  40                  45
Val Gly Gln Asp Leu Thr Val Met Ala Ala Ile Gly Leu Gly Phe Leu 
     50                  55                  60
Thr Ser Ser Phe Arg Arg His Ser Trp Ser Ser Val Ala Phe Asn Leu 
 65                  70                  75                  80
Phe Met Leu Ala Leu Gly Val Gln Trp Ala Ile Leu Leu Asp Gly Phe 
                 85                  90                  95
Leu Ser Gln Phe Pro Ser Gly Lys Val Val Ile Thr Leu Phe Ser Ile 
             100                105                110
Arg Leu Ala Thr Met Ser Ala Leu Ser Val Leu Ile Ser Val Asp Ala 
         115                120                125
Val Leu Gly Lys Val Asn Leu Ala Gln Leu Val Val Met Val Leu Val 
     130                135                140
Glu Val Thr Ala Leu Gly Asn Leu Arg Met Val Ile Ser Asn Ile Phe 
 145                150                155                160
Asn Thr Asp Tyr His Met Asn Met Met His Ile Tyr Val Phe Ala Ala 
                 165                170                175
Tyr Phe Gly Leu Ser Val Ala Trp Cys Leu Pro Lys Pro Leu Pro Glu 
             180                185                190
Gly Thr Glu Asp Lys Asp Gln Thr Ala Thr Ile Pro Ser Leu Ser Ala 
         195                200                205
Met Leu Gly Ala Leu Phe Leu Trp Met Phe Trp Pro Ser Phe Asn Ser 
     210                215                220
Ala Leu Leu Arg Ser Pro Ile Glu Arg Lys Asn Ala Val Phe Asn Thr 
 225                230                235                240
Tyr Tyr Ala Val Ala Val Ser Val Val Thr Ala Ile Ser Gly Ser Ser 
                 245                250                255
Leu Ala His Pro Gln Gly Lys Ile Ser Lys Thr Tyr Val His Ser Ala 
             260                265                270
Val Leu Ala Gly Gly Val Ala Val Gly Thr Ser Cys His Leu Ile Pro 
         275                280                285
Ser Pro Trp Leu Ala Met Val Leu Gly Leu Val Ala Gly Leu Ile Ser 
     290                295                300
Val Gly Gly Ala Lys Tyr Leu Pro Gly Cys Cys Asn Arg Val Leu Gly 
 305                310                315                320
Ile Pro His Ser Ser Ile Met Gly Tyr Asn Phe Ser Leu Leu Gly Leu 
                 325                330                335
Leu Gly Glu Ile Ile Tyr Ile Val Leu Leu Val Leu Asp Thr Val Gly 
             340                345                350
Ala Gly Asn Gly Met Ile Gly Phe Gln Val Leu Leu Ser Ile Gly Glu 
         355                360                365
Leu Ser Leu Ala Ile Val Ile Ala Leu Thr Ser Gly Leu Leu Thr Gly 
     370                375                380
Leu Leu Leu Asn Leu Lys Ile Trp Lys Ala Pro His Glu Ala Lys Tyr 
 385                390                395                400
Phe Asp Asp Gln Val Phe Trp Lys Phe Pro His Leu Ala Val Gly Phe 
                 405                410                415



<210> 249
<211> 1269
<212> DNA
<213> Rattus norvegicus
<308> AB015191
<400> 249

atgggctct  agtacccaa  gtccctccg  tgctgcctg  ccctgtggg  cttcgggct  60
caggtgact  ttatcctcc  cttctattt  ctcatcggc  aagacccta  ccaggcaga  120
cacaagttc  tggcgatct  tcaagtcat  caggatttg  cccttgtgg  agccttggg  180
ttcggcttc  tgtcctcat  ctttcggag  cacggctgg  gcagtgtgg  cttcagctt  240
ttcatgttg  cccttgggg  acaggggac  atcttgctg  actatttcc  gaattgggt  300
ctcgactgg  acatgatca  gaatccgtt  agtccgttt  tcagcatcc  gagagctac  360
ataagcacc  taccgctgc  gatctcagc  ggcgctgtc  tggggaagg  caacttggt  420
cagctggcc  tgatggtgc  ggtggaagc  atgaccttt  gtgccatca  agtcgctga  480
aagaaggtc  tcagaattg  agaccacat  atcatgatg  acggacacg  gtttggggc  540
tattttggg  tgactgtgg  atggtggct  tccaagtct  tgcccagga  aaggcatga  600
aacgcccag  cagaaaagg  tcagatgac  acgagctcc  gtctgtttg  catgctggg  660
accctcttc  tgtggatat  ctggccaag  atcaactct  ctctcctgg  agggacaaa  720
aaaaagaac  cagtgttca  cacctacta  gccctggca  tcagcacag  gacagccac  780
tccatgtcc  ccctgagtc  ccccaaagg  aagatcaac  tggttcaca  ccacaacgc  840
gtgctggct  ggggtgtgg  tgtcggtgc  ccgagttgc  tgatttctt  tccttggat  900
gctatggtc  tgggcctca  agctgggtt  atctccatc  ggggagcca  gtgtccaca  960
gtgtgtttg  gcgacttgc  gctgaaccc  agtgggatc  actacacct  cggcttgcc  1020
ggcctgctc  gagcactca  ctactactg  ctccatata  tagccgagt  caggccctc  1080
aatctctgg  ttgtcaccc  aacgatcac  gacgtcggg  ctctcagct  tgctatggc  1140
atgggaatg  tgactggac  gctgacagg  tgtctccta  gtgtcaaag  gtggagggc  1200
ccccatgca  tcaagtact  tgatgatca  gctttctgg  agttccccc  cttggctgt  1260
gaattttaa  1269



<210> 250
<211> 422
<212> PRT
<213> Rattus norvegicus
<308> NP_071950
<400> 250

Met Gly Ser Lys Tyr Pro Arg Ser Leu Arg Cys Cys Leu Pro Leu Trp 
  1               5                  10                  15
Ala Phe Gly Leu Gln Val Thr Phe Ile Leu Leu Phe Tyr Phe Leu Ile 
             20                  25                  30
Gly Gln Asp Pro Ile Gln Ala Asp His Lys Phe Met Ala Ile Tyr Gln 
         35                  40                  45
Val Ile Gln Asp Leu Thr Leu Val Ala Ala Leu Gly Phe Gly Phe Leu 
     50                  55                  60
Ser Ser Ser Phe Arg Arg His Gly Trp Ser Ser Val Ala Phe Ser Phe 
 65                  70                  75                  80
Phe Met Leu Ala Leu Gly Val Gln Gly Thr Ile Leu Leu Asp Tyr Phe 
                 85                  90                  95
Leu Asn Trp Val Leu Asp Trp Asn Met Ile Lys Asn Pro Phe Ser Pro 
             100                105                110
Phe Leu Ser Ile Gln Arg Ala Thr Ile Ser Thr Leu Pro Leu Leu Ile 
         115                120                125
Ser Ala Gly Ala Val Leu Gly Lys Val Asn Leu Val Gln Leu Ala Val 
     130                135                140
Met Val Leu Val Glu Ala Met Thr Phe Gly Ala Ile Arg Val Ala Asp 
 145                150                155                160
Lys Lys Val Phe Arg Ile Glu Asp His Ile Ile Met Met Tyr Gly His 
                 165                170                175
Val Phe Gly Ala Tyr Phe Gly Leu Thr Val Ala Trp Trp Leu Ser Lys 
             180                185                190
Ser Leu Pro Arg Arg Arg His Glu Asn Ala Gln Thr Glu Lys Val Gln 
         195                200                205
Met Thr Thr Ser Ser Ser Leu Phe Ala Met Leu Gly Thr Leu Phe Leu 
     210                215                220
Trp Ile Phe Trp Pro Ser Ile Asn Ser Ala Leu Leu Glu Gly Thr Lys 
 225                230                235                240
Lys Lys Asn Ala Val Phe Asn Thr Tyr Tyr Ala Leu Ala Val Ser Thr 
                 245                250                255
Val Thr Ala Thr Ser Met Ser Ala Leu Ser His Pro Lys Gly Lys Ile 
             260                265                270
Asn Met Val His Ile His Asn Ala Val Leu Ala Gly Gly Val Ala Val 
         275                280                285
Gly Ala Pro Ser Cys Leu Ile Ser Ser Pro Trp Ile Ala Met Val Leu 
     290                295                300
Gly Leu Thr Ala Gly Leu Ile Ser Ile Trp Gly Ala Lys Cys Pro Gln 
 305                310                315                320
Val Cys Leu Ser Asp Leu Leu Leu Asn Pro Ser Gly Ile His Tyr Thr 
                 325                330                335
Phe Gly Leu Pro Gly Leu Leu Gly Ala Leu Thr Tyr Tyr Cys Leu His 
             340                345                350
Ile Ile Ala Glu Ser Arg Pro Ser Asn Leu Trp Ile Val Thr Gln Thr 
         355                360                365
Ile Thr Asp Val Gly Ala Leu Ser Phe Ala Met Ala Met Gly Met Val 
     370                375                380
Thr Gly Leu Leu Thr Gly Cys Leu Leu Ser Val Lys Val Trp Arg Ala 
 385                390                395                400
Pro His Ala Val Lys Tyr Phe Asp Asp Gln Ala Phe Trp Glu Phe Pro 
                 405                410                415
His Leu Ala Val Glu Phe 
             420



<210> 251
<211> 1254
<212> DNA
<213> Homo sapiens
<308> S82449
<400> 251

atgagctct  agtacccgc  gtctgtccg  cgctgcctg  ccctctggg  cctaacact  60
gaagcagct  tcattctcc  cttctattt  tttacccac  atgacgctt  cttagagga  120
caaaagggg  tcgtggcat  ctatcaagt  ggccaagat  tgaccgtga  ggcggccat  180
ggcttgggc  tcctcacct  gagtttccg  agacacagc  ggagcagtg  ggccttcaa  240
ctcttcatg  tggcgcttg  tgtgcagtg  gcaatcctg  tggacggct  cctgagcca  300
ttcccttct  ggaaggtgg  catcacact  ttcagtatt  ggctggcca  catgagtgc  360
atgtcggtg  tgatctcag  gggtgctgt  ttggggaag  tcaacttgg  gcagttggt  420
gtgatggtg  tggtggagg  gacagcttt  ggcaccctg  ggatggtca  cagtaatat  480
ttcaacaca  actaccaca  gaacatgat  cacatctac  tgttcgcag  ctattttgg  540
ctgtctgtg  cctggtgcc  gccaaagcc  ctacccgag  gaacggagg  taaagatca  600
acagcaacg  tacccagtt  gtctgccat  ctgggcgcc  tcttcttgt  gatgttctg  660
ccaagtttc  actctgctc  gctgagaag  ccaatcgaa  ggaagaatg  cgtgttcaa  720
acctactat  ctgtagcag  cagtgtggt  acagccatc  cagggtcat  cttggctca  780
ccccaaggg  agatcagca  gacttatgt  cacagtgcg  tgttggcag  aggcgtggc  840
gtgggtacc  cgtgtcacc  gatcccttc  ccgtggctt  ccatggtgc  gggtcttgt  900
gctgggctg  tctccgtcg  gggagccaa  tacctgccg  ggtgttgta  ccgagtgct  960
gggattccc  acagctcca  catgggcta  aacttcagc  tgctgggtc  gcttggaga  1020
atcatctac  ttgtgctgc  ggtgcttga  accgtcgga  ccggcaatg  catgattgg  1080
ttccaggtc  tcctcagca  tggggaact  agcttggcc  tcgtgatag  tctcacgtc  1140
ggtctcctg  caggtttgc  cctaaatct  aaaatatgg  aagcacctc  tgaggctaa  1200
tattttgat  accaagttt  ctggaagtt  cctcatttg  ctgttggat  ttaa  1254



<210> 252
<211> 416
<212> PRT
<213> Homo sapiens
<308> Q9UQ21
<400> 252

Ser Ser Lys Tyr Pro Arg Ser Val Arg Arg Cys Leu Pro Leu Trp Ala 
  1               5                  10                  15
Leu Thr Leu Glu Ala Ala Leu Ile Leu Leu Phe Tyr Phe Phe Thr His 
             20                  25                  30
Tyr Asp Ala Ser Leu Glu Asp Gln Lys Gly Leu Val Ala Ser Tyr Gln 
         35                  40                  45
Val Gly Gln Asp Leu Thr Val Met Ala Ala Ile Gly Leu Gly Phe Leu 
     50                  55                  60
Thr Ser Ser Phe Arg Arg His Ser Trp Ser Ser Val Ala Phe Asn Leu 
 65                  70                  75                  80
Phe Met Leu Ala Leu Gly Val Gln Trp Ala Ile Leu Leu Asp Gly Phe 
                 85                  90                  95
Leu Ser Gln Phe Pro Ser Gly Lys Val Val Ile Thr Leu Phe Ser Ile 
             100                105                110
Arg Leu Ala Thr Met Ser Ala Leu Ser Val Leu Ile Ser Val Asp Ala 
         115                120                125
Val Leu Gly Lys Val Asn Leu Ala Gln Leu Val Val Met Val Leu Val 
     130                135                140
Glu Val Thr Ala Leu Gly Asn Leu Arg Met Val Ile Ser Asn Ile Phe 
 145                150                155                160
Asn Thr Asp Tyr His Met Asn Met Met His Ile Tyr Val Phe Ala Ala 
                 165                170                175
Tyr Phe Gly Leu Ser Val Ala Trp Cys Leu Pro Lys Pro Leu Pro Glu 
             180                185                190
Gly Thr Glu Asp Lys Asp Gln Thr Ala Thr Ile Pro Ser Leu Ser Ala 
         195                200                205
Met Leu Gly Ala Leu Phe Leu Trp Met Phe Trp Pro Ser Phe Asn Ser 
     210                215                220
Ala Leu Leu Arg Ser Pro Ile Glu Arg Lys Asn Ala Val Phe Asn Thr 
 225                230                235                240
Tyr Tyr Ala Val Ala Val Ser Val Val Thr Ala Ile Ser Gly Ser Ser 
                 245                250                255
Leu Ala His Pro Gln Gly Lys Ile Ser Lys Thr Tyr Val His Ser Ala 
             260                265                270
Val Leu Ala Gly Gly Val Ala Val Gly Thr Ser Cys His Leu Ile Pro 
         275                280                285
Ser Pro Trp Leu Ala Met Val Leu Gly Leu Val Ala Gly Leu Ile Ser 
     290                295                300
Val Gly Gly Ala Lys Tyr Leu Pro Gly Cys Cys Asn Arg Val Leu Gly 
 305                310                315                320
Ile Pro His Ser Ser Ile Met Gly Tyr Asn Phe Ser Leu Leu Gly Leu 
                 325                330                335
Leu Gly Glu Ile Ile Tyr Ile Val Leu Leu Val Leu Asp Thr Val Gly 
             340                345                350
Ala Gly Asn Gly Met Ile Gly Phe Gln Val Leu Leu Ser Ile Gly Glu 
         355                360                365
Leu Ser Leu Ala Ile Val Ile Ala Leu Thr Ser Gly Leu Leu Thr Gly 
     370                375                380
Leu Leu Leu Asn Leu Lys Ile Trp Lys Ala Pro His Glu Ala Lys Tyr 
 385                390                395                400
Phe Asp Asp Gln Val Phe Trp Lys Phe Pro His Leu Ala Val Gly Phe 
                 405                410                415



<210> 253
<211> 1420
<212> DNA
<213> Rattus norvegicus
<308> AB015946
<400> 253

ccggaattc  ccatggcga  gccgagaga  atcatcacc  tacagttgg  ccagtgcgg  60
aatcagatt  ggttcgagt  ctggaaaca  ctatgtgct  agcatggca  cagccccga  120
ggcatcgta  aggagttcg  caccgaggg  actgaccgc  aggacgtct  tttctacca  180
gcagacgat  agcattaca  cccccgggc  gtgctgctg  acctggagc  ccgggtgat  240
cattccatc  tcaactcct  ctatgccaa  ctctacaac  cagagaaca  ctacctgtc  300
gagcatgga  gaggggctg  caacaactg  gccagcgga  tctcccagg  agaaaaaat  360
cacgaggac  tttttgaca  cattgatcg  gaggcagat  gcagtgaca  cctagaggg  420
tttgtactg  gtcactcca  tgctggggg  acaggctct  gcttgggct  ctacctctt  480
gaacggcta  atgacaggt  ccccaaaaa  ctagtgcag  cgtactccg  gttccccaa  540
caggacgag  tgagtgacg  ggtggtcca  ccctacaac  ccctcctca  gttaaagag  600
ctgacccag  acgcggact  tgtggtggt  ctggacaac  cggccctga  cctgatcgc  660
acagaccgc  tgcacatcc  gaacccatc  ttctcccag  tcaaccagc  ggtgtccac  720
atcatgtca  ccagcacca  caccctgcg  taccccgga  acatgaaca  cgacctcat  780
ggcctcatc  cctcactca  tcccacccc  cgactacac  tcctcatga  tggctatac  840
cccctcacc  cggaccagt  agtggccag  gtgaggaag  caacagtcc  ggatgtcat  900
aggagactg  tacagccca  gaacgtgat  gtgtccaca  gtcgggatc  tcagaccaa  960
cactgctac  tcgccatcc  caacatcat  cagggagag  tggacccca  ccaggtcca  1020
aagagcctg  agaggatcc  ggagaggaa  ttggccaac  ttatcccct  gggcccggc  1080
agcatccag  tggccctgt  aaggaagtc  ccatacctg  cctcagccc  ccgggtcag  1140
gggctcatg  tggccaacc  caccagtat  tcctcgctt  ttgaaagga  ctgtcgcca  1200
tttgacaag  tgaggaaac  ggaggcctt  atggagcag  tccgcaagg  ggacatctt  1260
aaggacaat  ttgacgaga  ggacacctc  agggagatt  tgcagcagc  gattgacga  1320
taccatgcg  ccacacggc  agactacat  tcctggggc  cccaggagc  atgagtcgc  1380
cgagacagg  accctcatc  gccttaccg  ttagccatgg  1420



<210> 254
<211> 451
<212> PRT
<213> Rattus norvegicus
<308> Q9Z310
<400> 254

Met Pro Arg Glu Ile Ile Thr Leu Gln Leu Gly Gln Cys Gly Asn Gln 
  1               5                  10                  15
Ile Gly Phe Glu Phe Trp Lys Gln Leu Cys Ala Glu His Gly Ile Ser 
             20                  25                  30
Pro Glu Gly Ile Val Glu Glu Phe Ala Thr Glu Gly Thr Asp Arg Lys 
         35                  40                  45
Asp Val Phe Phe Tyr Gln Ala Asp Asp Glu His Tyr Ile Pro Arg Ala 
     50                  55                  60
Val Leu Leu Asp Leu Glu Pro Arg Val Ile His Ser Ile Leu Asn Ser 
 65                  70                  75                  80
Ser Tyr Ala Lys Leu Tyr Asn Pro Glu Asn Ile Tyr Leu Ser Glu His 
                 85                  90                  95
Gly Gly Gly Ala Gly Asn Asn Trp Ala Ser Gly Phe Ser Gln Gly Glu 
             100                105                110
Lys Ile His Glu Asp Ile Phe Asp Ile Ile Asp Arg Glu Ala Asp Gly 
         115                120                125
Ser Asp Ser Leu Glu Gly Phe Val Leu Cys His Ser Ile Ala Gly Gly 
     130                135                140
Thr Gly Ser Gly Leu Gly Ser Tyr Leu Leu Glu Arg Leu Asn Asp Arg 
 145                150                155                160
Tyr Pro Lys Lys Leu Val Gln Thr Tyr Ser Val Phe Pro Asn Gln Asp 
                 165                170                175
Glu Met Ser Asp Val Val Val Gln Pro Tyr Asn Ser Leu Leu Thr Leu 
             180                185                190
Lys Arg Leu Thr Gln Asn Ala Asp Cys Val Val Val Leu Asp Asn Thr 
         195                200                205
Ala Leu Asn Leu Ile Ala Thr Asp Arg Leu His Ile Gln Asn Pro Ser 
     210                215                220
Phe Ser Gln Ile Asn Gln Leu Val Ser Thr Ile Met Ser Ala Ser Thr 
 225                230                235                240
Thr Thr Leu Arg Tyr Pro Gly Tyr Met Asn Asn Asp Leu Ile Gly Leu 
                 245                250                255
Ile Ala Ser Leu Ile Pro Thr Pro Arg Leu His Phe Leu Met Thr Gly 
             260                265                270
Tyr Thr Pro Leu Thr Thr Asp Gln Ser Val Ala Ser Val Arg Lys Thr 
         275                280                285
Thr Val Leu Asp Val Met Arg Arg Leu Leu Gln Pro Lys Asn Val Met 
     290                295                300
Val Ser Thr Gly Arg Asp Arg Gln Thr Asn His Cys Tyr Ile Ala Ile 
 305                310                315                320
Leu Asn Ile Ile Gln Gly Glu Val Asp Pro Thr Gln Val His Lys Ser 
                 325                330                335
Leu Gln Arg Ile Arg Glu Arg Lys Leu Ala Asn Phe Ile Pro Trp Gly 
             340                345                350
Pro Ala Ser Ile Gln Val Ala Leu Ser Arg Lys Ser Pro Tyr Leu Pro 
         355                360                365
Ser Ala His Arg Val Ser Gly Leu Met Met Ala Asn His Thr Ser Ile 
     370                375                380
Ser Ser Leu Phe Glu Arg Thr Cys Arg Gln Phe Asp Lys Leu Arg Lys 
 385                390                395                400
Arg Glu Ala Phe Met Glu Gln Phe Arg Lys Glu Asp Ile Phe Lys Asp 
                 405                410                415
Asn Phe Asp Glu Met Asp Thr Ser Arg Glu Ile Val Gln Gln Leu Ile 
             420                425                430
Asp Glu Tyr His Ala Ala Thr Arg Pro Asp Tyr Ile Ser Trp Gly Thr 
         435                440                445
Gln Glu Gln 
     450



<210> 255
<211> 1654
<212> DNA
<213> Homo sapiens
<308> BC000619
<400> 255

ggcacgagg  cgggctggc  tgcggcgcc  ttgcgggcg  gagcggctg  aacgccggt  60
cctgaggag  gatgccgag  gaaatcatc  ccctacagt  gggccagtg  ggcaatcag  120
ttgggttcg  gttctggaa  cagctgtgc  ccgagcatg  tatcagccc  gagggcatc  180
tggaggagt  cgccaccga  ggcactgac  gcaaggacg  ctttttcta  caggcagac  240
atgagcact  catcccccg  gccgtgctg  tggacttgg  accccgggt  atccactcc  300
tcctcaact  cccctatgc  aagctctac  acccagaga  catctacct  tcggaacat  360
gaggaggag  tggcaacaa  tgggccagc  gattctccc  gggagaaaa  atccatgag  420
acatttttg  catcataga  cgggaggca  atggtagtg  cagtctaga  ggctttgtg  480
tgtgtcact  cattgctgg  gggacaggc  ctggactgg  ttcctacct  ttagaacgg  540
tgaatgaca  gtatcctaa  aagctggtg  agacatact  agtgtttcc  aaccaggac  600
agatgagcg  tgtggtggt  cagccttac  attcactcc  cacactcaa  aggctgacg  660
agaatgcag  ctgtgtggt  gtgctggac  acacagccc  gaaccggat  gccacagac  720
gcctgcaca  ccagaaccc  tccttctcc  agatcaacc  gctggtgtc  accatcatg  780
cagccagca  caccaccct  cgctaccct  gctacatga  caatgacct  atcggcctc  840
tcgcctcgc  cattcccac  ccacggctc  acttcctca  gaccggcta  acccctctc  900
ctacggacc  gtcagtggc  agcgtgagg  agaccacgg  cctggatgt  atgaggcgg  960
tgctgcagc  caagaacgt  atggtgtcc  caggccgag  ccgccagac  aaccactgc  1020
acatcgcca  cctcaacat  atccaggga  aggtggacc  cacccaggt  cacaagagc  1080
tgcagagga  ccgggaacg  aagttggcc  acttcatcc  gtggggccc  gccagcatc  1140
aggtggccc  gtcgaggaa  tctccctac  tgccctcgg  ccaccgggt  agcgggctc  1200
tgatggcca  ccacaccag  atctcctcg  tcttcgaga  aacctgtcg  cagtatgac  1260
agctgcgta  gcgggaggc  ttcctggag  agttccgca  ggaggacat  ttcaaggac  1320
actttgatg  gatggacac  tccagggag  ttgtgcagc  gctcatcga  gagtaccat  1380
cggccacac  gccagacta  atctcctgg  gcacccagg  gcagtgagt  ccccaggac  1440
gggaccctc  tctgcctta  tggttggcc  aagccctgc  tgactgacc  ccccctcag  1500
gcacagatc  gggacctca  gcatctctt  ctcatatac  tggactctc  gttggcctg  1560
aaacacatt  acttctcct  ttatgagac  atttatctt  aataaagca  tggatataa  1620
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaa  1654



<210> 256
<211> 451
<212> PRT
<213> Homo sapiens
<308> P23258
<400> 256

Met Pro Arg Glu Ile Ile Thr Leu Gln Leu Gly Gln Cys Gly Asn Gln 
  1               5                  10                  15
Ile Gly Phe Glu Phe Trp Lys Gln Leu Cys Ala Glu His Gly Ile Ser 
             20                  25                  30
Pro Glu Gly Ile Val Glu Glu Phe Ala Thr Glu Gly Thr Asp Arg Lys 
         35                  40                  45
Asp Val Phe Phe Tyr Gln Ala Asp Asp Glu His Tyr Ile Pro Arg Ala 
     50                  55                  60
Val Leu Leu Asp Leu Glu Pro Arg Val Ile His Ser Ile Leu Asn Ser 
 65                  70                  75                  80
Pro Tyr Ala Lys Leu Tyr Asn Pro Glu Asn Ile Tyr Leu Ser Glu His 
                 85                  90                  95
Gly Gly Gly Ala Gly Asn Asn Trp Ala Ser Gly Phe Ser Gln Gly Glu 
             100                105                110
Lys Ile His Glu Asp Ile Phe Asp Ile Ile Asp Arg Glu Ala Asp Gly 
         115                120                125
Ser Asp Ser Leu Glu Gly Phe Val Leu Cys His Ser Ile Ala Gly Gly 
     130                135                140
Thr Gly Ser Gly Leu Gly Ser Tyr Leu Leu Glu Arg Leu Asn Asp Arg 
 145                150                155                160
Tyr Pro Lys Lys Leu Val Gln Thr Tyr Ser Val Phe Pro Asn Gln Asp 
                 165                170                175
Glu Met Ser Asp Val Val Val Gln Pro Tyr Asn Ser Leu Leu Thr Leu 
             180                185                190
Lys Arg Leu Thr Gln Asn Ala Asp Cys Val Val Val Leu Asp Asn Thr 
         195                200                205
Ala Leu Asn Arg Ile Ala Thr Asp Arg Leu His Ile Gln Asn Pro Ser 
     210                215                220
Phe Ser Gln Ile Asn Gln Leu Val Ser Thr Ile Met Ser Ala Ser Thr 
 225                230                235                240
Thr Thr Leu Arg Tyr Pro Gly Tyr Met Asn Asn Asp Leu Ile Gly Leu 
                 245                250                255
Ile Ala Ser Leu Ile Pro Thr Pro Arg Leu His Phe Leu Met Thr Gly 
             260                265                270
Tyr Thr Pro Leu Thr Thr Asp Gln Ser Val Ala Ser Val Arg Lys Thr 
         275                280                285
Thr Val Leu Asp Val Met Arg Arg Leu Leu Gln Pro Lys Asn Val Met 
     290                295                300
Val Ser Thr Gly Arg Asp Arg Gln Thr Asn His Cys Tyr Ile Ala Ile 
 305                310                315                320
Leu Asn Ile Ile Gln Gly Glu Val Asp Pro Thr Gln Val His Lys Ser 
                 325                330                335
Leu Gln Arg Ile Arg Glu Arg Lys Leu Ala Asn Phe Ile Pro Trp Gly 
             340                345                350
Pro Ala Ser Ile Gln Val Ala Leu Ser Arg Lys Ser Pro Tyr Leu Pro 
         355                360                365
Ser Ala His Arg Val Ser Gly Leu Met Met Ala Asn His Thr Ser Ile 
     370                375                380
Ser Ser Leu Phe Glu Arg Thr Cys Arg Gln Tyr Asp Lys Leu Arg Lys 
 385                390                395                400
Arg Glu Ala Phe Leu Glu Gln Phe Arg Lys Glu Asp Met Phe Lys Asp 
                 405                410                415
Asn Phe Asp Glu Met Asp Thr Ser Arg Glu Ile Val Gln Gln Leu Ile 
             420                425                430
Asp Glu Tyr His Ala Ala Thr Arg Pro Asp Tyr Ile Ser Trp Gly Thr 
         435                440                445
Gln Glu Gln 
     450



<210> 257
<211> 3202
<212> DNA
<213> Rattus norvegicus
<308> AB016161
<400> 257

agacacctc  ccgacgccc  cccagaagc  ttccccaga  gaagtgtcc  ccctgagct  60
cccccccac  ccaaggagg  cgcccccgc  cctcctcgc  atgggcccg  ggggaccct  120
taccccagt  gggtggccg  tgcctcttc  gctggtgat  gcggctggg  tggctccgg  180
gtgggcctc  cactcccct  atctcccgc  gcctcaccc  agggtcccc  cgcacccct  240
ctcagaacg  cgtgcagta  acatcgggg  gctgtttcc  atgagcggg  gctggccgg  300
gggccaggc  tgccagccc  cggtggaga  ggcgctgga  gacgttaac  gccgcagag  360
catcctgcc  gactacgag  tcaagctta  ccaccacga  agcaagtgt  acccagggc  420
agccaccaa  tacttgtac  aactactct  caatgaccc  atcaagatc  ttctcatgc  480
tggctgtag  tctgtctcc  cacttgtag  tgaggctgc  cggatgtgg  accttattg  540
gctctcata  ggctccagt  caccagcct  gtcaaaccg  cagcggttt  ccacgttct  600
ccggacgca  ccatccgcc  cactccaca  tcccacccg  gtgaaactc  tcgaaaagt  660
gggctggaa  aagatcgct  ccatccaac  gaccaccga  gtcttcacc  caacgctgg  720
tgacctgga  gagcgagtg  aagaggctg  gatcgagat  actttccga  agagtttct  780
ctcggatcc  gctgtgcct  ttaaaaacc  gaagcgtca  gatgctcga  tcatcgtgg  840
acttttcta  gagacggaa  cccggaaag  tttttgtga  gtctataag  aaaggctct  900
tgggaagaa  tacgtctgg  tcctcatcg  gtggtatgc  gacaactgg  tcaagacct  960
tgacccgtc  atcaattgt  cagtggaag  aatgaccga  gcggtggag  gccacatca  1020
cacggagat  gtcatgctg  accctgcca  cacccgaag  atttccaac  tgacgtcac  1080
ggaatttgt  gagaaacta  ccaagcggc  gaaaagaca  cccgaggag  ctggaggct  1140
ccaggaggc  ccactggcc  atgatgcta  ctgggcctt  gctttggcc  tgaacaaga  1200
gtctggagg  ggtggtcgt  ccggcgtgc  cctggagga  tttaactac  acaaccaga  1260
cattacaga  cagatctac  gggccatga  ctcctcctc  tttgagggc  tttctggcc  1320
tgtggtctt  gatgccagc  gctcccgga  ggcatggac  cttatcgag  agctacagg  1380
cggcagcta  aagaagatc  gctactacg  cagcaccaa  gatgatctt  cctggtcca  1440
aacggacaa  tggattgga  ggtctcccc  agctgacca  accttggtc  tcaagacat  1500
ccgtttcct  tctcagaaa  tctttatct  cgtctcagt  ctctccagc  tgggcattg  1560
tcttgctgt  gtctgtctg  cctttaaca  ctacaactc  cacgttcgt  atatccaga  1620
ctcccagcc  aacctgaac  atctgactg  tgtgggctg  tcactggca  tggctgctg  1680
cttccctct  gggctggat  gttaccaca  agggagaag  cagttcccg  ttgtctgcc  1740
ggcccgcct  tggctcttg  gcttgggct  tagtctggg  tatggctct  tgttcacca  1800
gatctggtg  gtccacaca  tcttcacga  gaaggagga  aagaaggag  ggaggaaga  1860
cctagagcc  tggaaactc  atgccactg  gggcctgct  gtgggcatg  atgtcctga  1920
tcttgccat  tggcagatt  tggacccct  gcaccgaac  attgagact  ttgccaagg  1980
ggaaccaaa  gaagacatc  atgtctcca  tctgcccca  ttggagcac  gcagctcca  2040
gaagatgaa  acgtggctt  gcattttct  tggttacaa  gggctgctg  tgctgctgg  2100
aatctttct  gcttacgaa  ccaagagcg  gtccactga  aagatcaat  accacaggg  2160
cgtgggcat  gctatctac  atgtcgcgg  cctgtgtct  atcactgct  ctgtgacca  2220
gatcctttc  agtcagcag  acgcagcct  tgcctttgc  tctctggcc  tcgtgttct  2280
ttcctacat  actctggtt  tgctctttg  gcccaagat  cgcaggctg  tcacccgag  2340
ggaatggca  tctgaaacg  aggacacca  gaaaacagg  tcatccacc  acaacaacg  2400
ggaagagaa  tcccgactg  tggagaagg  aaaccgaga  ctggaaaag  tcatcgctg  2460
ggtgtgcgg  gacaaacaa  cggggcccc  cgtgtctga  ggtgggttg  ccgtagtgg  2520
gccttcgat  gaggtttga  tgttggtgg  tcacagagg  tctcggcct  cagaggaac  2580
ggagaggga  aggggaagg  ttgagtttc  gtcccgtca  cccgaggag  gggaggggg  2640
ttctgcaga  ttcagccca  ctgaggcaa  agagcagtc  ctggcagta  ttaggggga  2700
gccattgtg  gacattggt  gcccacagt  ttactgtgt  cgggctgta  ttagggacc  2760
tgcagtgct  ggtgggggc  ggaaatggc  tttccactt  tctgatgca  tcttcattt  2820
ttccttttt  ttttttttt  aaatcactg  ttttctcca  ctattctct  ggtgccatt  2880
cgttctgtg  gcttccttt  ttctcccct  attcacatt  taatttcct  tctcactcg  2940
acatctcgt  tcatcgtct  cccccccct  cctccttcc  ttccacatc  ccctcctcc  3000
acactcccg  ttgtgtttc  tcctccaga  agaggagcg  gtctctgaa  tgcgccatc  3060
gctccagtc  cggcagcaa  tccgctcac  gcgccaccc  ccaacaccc  cagatccct  3120
tggaggcct  cccagggga  cctctgagc  ccctgaccg  cttagctgt  atgggagtc  3180
agtacattt  ctttacaag  ga  3202



<210> 258
<211> 991
<212> PRT
<213> Rattus norvegicus
<308> Q9Z0U4
<400> 258

Met Leu Leu Leu Leu Leu Val Pro Leu Phe Leu Arg Pro Leu Gly Ala 
  1               5                  10                  15
Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile Ile 
             20                  25                  30
His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg Asp 
         35                  40                  45
Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu Tyr 
     50                  55                  60
Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys Cys 
 65                  70                  75                  80
Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys Val 
                 85                  90                  95
Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val Phe 
             100                105                110
Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Glu Phe 
         115                120                125
Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Val Cys 
     130                135                140
Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn Arg 
 145                150                155                160
Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe Pro 
                 165                170                175
Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val Glu 
             180                185                190
Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp Tyr 
         195                200                205
Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln Ala 
     210                215                220
Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile Ile 
 225                230                235                240
Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala Ala 
                 245                250                255
Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro Ala 
             260                265                270
Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro Ser 
         275                280                285
Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp Gly 
     290                295                300
Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr Ser 
 305                310                315                320
Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu Ile 
                 325                330                335
Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys Asn 
             340                345                350
Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu Thr 
         355                360                365
Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe Gly 
     370                375                380
Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp Phe 
 385                390                395                400
Lys Thr Tyr Asp Pro Ser Ile Asn Cys Thr Val Glu Glu Met Thr Glu 
                 405                410                415
Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro Ala 
             420                425                430
Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu Lys 
         435                440                445
Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe Gln 
     450                455                460
Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala Leu 
 465                470                475                480
Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu Asp 
                 485                490                495
Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala Met 
             500                505                510
Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp Ala 
         515                520                525
Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly Gly 
     530                535                540
Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu Ser 
 545                550                555                560
Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp Gln 
                 565                570                575
Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe Ile 
             580                585                590
Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val Cys 
         595                600                605
Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn Ser 
     610                615                620
Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala Leu 
 625                630                635                640
Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg Ser 
                 645                650                655
Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu Gly 
             660                665                670
Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val His 
         675                680                685
Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr Leu 
     690                695                700
Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met Asp 
 705                710                715                720
Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg Thr 
                 725                730                735
Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val Ser 
             740                745                750
Ile Leu Pro Gln Leu Glu His Cys Ser Ser Lys Lys Met Asn Thr Trp 
         755                760                765
Leu Gly Glu Leu Trp Ser Phe Ala Val Ser Ser Asp Val Gln Arg Arg 
     770                775                780
Ala Thr Val Gly Gly Asp Ser Pro Ile Cys Val Trp Pro Ala Pro Glu 
 785                790                795                800
Ser Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly Ile Phe 
                 805                810                815
Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn Asp His 
             820                825                830
Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys Leu Ile 
         835                840                845
Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala Ala Phe 
     850                855                860
Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu Val 
 865                870                875                880
Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly Glu Trp 
                 885                890                895
Gln Ser Glu Thr Gln Asp Thr Met Lys Thr Gly Ser Ser Thr Asn Asn 
             900                905                910
Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu Leu 
         915                920                925
Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu Arg His 
     930                935                940
Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro Pro Thr 
 945                950                955                960
Pro Pro Asp Pro Ser Gly Gly Leu Pro Arg Gly Pro Ser Glu Pro Pro 
                 965                970                975
Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr Lys 
             980                985                990



<210> 259
<211> 4445
<212> DNA
<213> Homo sapiens
<308> AJ225028
<400> 259

cgctccccg  tcccgtggc  gccgccgcc  cggggaaga  gagacaggg  tggggtttg  60
gggaagcga  agaggaggg  agagaccct  gccaggctg  agcctggat  cgaggggag  120
agggacggg  ggaggagaa  ggtggagga  aagggaggg  ggagcgggg  ggagcggcc  180
ggcctgggg  cttgaggcc  ggggagagc  ggggagccg  gcccgcgcg  cgagatgtt  240
ctgctgctg  tactggcgc  actcttcct  cgccccccg  gcgcgggcg  ggcgcagac  300
cccaacgcc  cctcagaag  ttgccagat  atacacccg  cctgggaag  gggcatcag  360
taccggggc  tgactcggg  ccaggtgaa  gctatcaac  tcctgccag  ggactatga  420
attgagtat  tgtgccggg  ggagcgcga  gtggtgggg  ccaaggtcc  caagtgcct  480
gccaacggc  cctggacag  tatggacac  cccagccgc  gtgtccgaa  ctgctccaa  540
tcttatttg  ccctggaaa  tgggaaggt  ttcctgacg  gtggggacc  cccagctct  600
gacggagcc  gggtggatt  ccggtgtga  cccgacttc  atctggtgg  cagctcccg  660
agcatctgt  gtcagggcc  gtggagcac  cccaagccc  actgccagg  gaatcgaac  720
ccacactca  aacggcgcg  agtgtacat  ggggcactg  ttcccatga  cgggggctg  780
ccagggggc  aggcctgcc  gcccgcggt  gagatggcg  tggaggacg  gaatagccg  840
agggacatc  tgccggact  tgagctcaa  ctcatccac  acgacagca  gtgtgatcc  900
ggccaagcc  ccaagtacc  atatgagct  ctctacaac  accctatca  gatcatcct  960
atgcctggc  gcagctctg  ctccacgct  gtggctgag  ctgctagga  gtggaacct  1020
attgtgctt  cctatggct  cagctcacc  gccctgtca  accggcagc  tttccccac  1080
ttcttccga  cgcacccat  agccacact  cacaaccct  cccgcgtga  actctttga  1140
aagtggggc  ggaagaaga  tgctaccat  cagcagacc  ctgaggtct  cacttcgac  1200
ctggacgac  tggaggaac  agtgaagga  gctggaatt  agattactt  ccgccagag  1260
ttcttctca  atccagctg  gcccgtcaa  aacctgaag  gccaggatg  ccgaatcat  1320
gtgggactt  tctatgaga  tgaagcccg  aaagttttt  gtgaggtgt  caaggagcg  1380
ctctttggg  agaagtacg  ctggttcct  attgggtgg  atgctgaca  ttggttcaa  1440
atctacgac  cttctatca  ctgcacagt  gatgagatg  ctgaggcgg  ggagggcca  1500
atcacaact  agattgtca  gctgaatcc  gccaatacc  gcagcattt  caacatgac  1560
tcccaggaa  ttgtggaga  actaaccaa  cgactgaaa  gacaccctg  ggagacagg  1620
ggcttccag  aggcaccgc  ggcctatga  gccatctgg  ccttggcac  ggccctgaa  1680
aagacatct  gaggaggcg  ccgttctgg  gtgcgcctg  aggacttca  ctacaacaa  1740
cagaccatt  ccgaccaaa  ctaccgggc  atgaactct  cgtcctttg  gggtgtctc  1800
ggccatgtg  tgtttgatg  cagcggctc  cggatggca  ggacgctta  cgagcagct  1860
cagggtggc  gctacaaga  gattggcta  tatgacagc  ccaaggatg  tctttcctg  1920
tccaaaaca  ataaatgga  tggagggtc  cccccagct  accagaccc  ggtcatcaa  1980
acattccgc  tcctgtcac  gaaactctt  atctccgtc  cagttctct  cagcctggg  2040
attgtccta  ctgttgtct  tctgtcctt  aacatctac  actcacatg  ccgttatat  2100
cagaactca  agcccaacc  gaacaacct  actgctgtg  gctgctcac  ggctttagc  2160
gctgtcttc  ccctggggc  cgatggtta  cacattggg  ggaaccagt  tcctttcgt  2220
tgccaggcc  gcctctggc  cctgggcct  ggctttagt  tgggctacg  ttccatgtt  2280
accaagatt  ggtgggtcc  cacggtctt  acaaagaag  aagaaaaga  ggagtggag  2340
aagactctg  aaccctgga  gctgtatgc  acagtgggc  tgctggtgg  catggatgt  2400
ctcactctc  ccatctggc  gatcgtgga  cctctgcac  ggaccattg  gacatttgc  2460
aaggaggaa  ctaaggaag  tattgacgt  tctattctg  cccagctgg  gcattgcag  2520
tccaggaag  tgaatacat  gcttggcat  ttctatggt  acaaggggc  gctgctgct  2580
ctgggaatc  tccttgctt  tgagaccaa  agtgtgtcc  ctgagaaga  caatgatca  2640
cgggctgtg  gcatggcta  ctacaatgt  gcagtcctg  gcctcatca  tgctcctgt  2700
accatgatt  tgtccagcc  gcaggatgc  gcctttgcc  ttgcctctc  tgccatagt  2760
ttctcctcc  atatcactc  tgttgtgct  tttgtgccc  agatgcgca  gctgatcac  2820
cgaggggaa  ggcagtcgg  ggcgcagga  accatgaag  cagggtcat  gaccaacaa  2880
aacgaggag  agaagtccc  gctgttgga  aaggagaac  gtgaactgg  aaagatcat  2940
gctgagaaa  aggagcgtg  ctctgaact  cgccatcaa  tccagtctc  gcagcagct  3000
cgctcccgg  gccacccac  gacaccccc  gaaccctct  ggggcctgc  caggggacc  3060
cctgagccc  ccgaccggc  tagctgtga  gggagtcga  tgcatttgc  ttataagtg  3120
gggtagggt  agggaggac  ggccagtag  gggagggaa  gggagaggg  aagggcagg  3180
gactcagga  gcagggggt  cccatcccc  gctgggaag  acatgctat  caatctcat  3240
tcttgtaaa  acatgtccc  ctgtgagtt  tgggctgat  tgggtctct  atacctctg  3300
gaaacagac  tttttctct  ttactgctt  atgtaattt  gtatcacct  ttcacaatt  3360
agttcgtac  tggcttgaa  ctgctcact  ctcacacgc  gcctcctca  cagcctcac  3420
gcatctttc  cttcccatg  aacaccctc  tctagttac  acggcaacc  ctgcagctc  3480
tctgccttt  tgctctgtt  ctgtccagc  ggggtctcc  aacaagtgc  ctttccacc  3540
caaaggggc  tctcctttt  tccactgtc  taatctctt  ccatcttac  tgcccttct  3600
tactttctc  catgtggct  cccctgaat  ttgcttcct  tgggagctc  ttcttttcg  3660
caaggctca  atgctcctt  cctctgctc  gtgcactca  gctcagcac  catgcatcc  3720
cccctctcc  gcgtgtgcc  actgaacat  ctcatgtgt  cacacgctt  tcccgtatg  3780
tttcttcat  ttcagtcac  tgtgctctc  ggtgccctg  attcacagc  acgtgtgcc  3840
ctctcatgg  catgggtct  cccttgagc  tgtttgggt  ggcatgtgc  atttgtcta  3900
catgctgag  catgtcttt  ctatttgca  acgtccatg  ttatccatg  actttccct  3960
tgtaccctc  atgtacctt  tgtactttc  tcccttaaa  catggtatt  ttctgacag  4020
gccatatgt  ccctaccct  cacattgtt  tgcactttt  cccaattca  gtttggtgg  4080
gccatccac  ccctctcct  gtcacagaa  ctccatttc  gctcagatt  cccccatct  4140
cattgcatt  atgtactac  ctcagtcta  actcacaat  atcttctcc  aagactgct  4200
ccttttgtt  tgtgttttt  tgaggggaa  taaggaaaa  taagtgggg  caggtttgg  4260
gagctgctt  cagtggata  ttgatgaga  tcctgacca  aggaaggca  ccttgactg  4320
tgggataga  agatggacc  atggggtgg  aggtggtgt  cctttcaca  tgtggtgtc  4380
cttggggaa  gatctcccc  aatctcaat  aaccagtga  cagtgtgac  cggcaaaaa  4440
aaaaa  4445



<210> 260
<211> 961
<212> PRT
<213> Homo sapiens
<308> Q9UBS5
<400> 260

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
  1               5                  10                  15
Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
             20                  25                  30
Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
         35                  40                  45
Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
     50                  55                  60
Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
 65                  70                  75                  80
Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                 85                  90                  95
Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
             100                105                110
Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
         115                120                125
Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
     130                135                140
Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
 145                150                155                160
Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                 165                170                175
Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
             180                185                190
Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
         195                200                205
Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
     210                215                220
Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
 225                230                235                240
Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                 245                250                255
Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
             260                265                270
Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
         275                280                285
Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
     290                295                300
Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
 305                310                315                320
Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                 325                330                335
Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
             340                345                350
Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
         355                360                365
Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
     370                375                380
Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
 385                390                395                400
Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                 405                410                415
Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
             420                425                430
Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
         435                440                445
Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
     450                455                460
Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
 465                470                475                480
Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu 
                 485                490                495
Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
             500                505                510
Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
         515                520                525
Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
     530                535                540
Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
 545                550                555                560
Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp 
                 565                570                575
Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe 
             580                585                590
Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val 
         595                600                605
Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn 
     610                615                620
Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala 
 625                630                635                640
Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg 
                 645                650                655
Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu 
             660                665                670
Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val 
         675                680                685
His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr 
     690                695                700
Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met 
 705                710                715                720
Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg 
                 725                730                735
Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val 
             740                745                750
Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr 
         755                760                765
Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly 
     770                775                780
Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn 
 785                790                795                800
Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys 
                 805                810                815
Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala 
             820                825                830
Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr 
         835                840                845
Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly 
     850                855                860
Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr 
 865                870                875                880
Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg 
                 885                890                895
Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu 
             900                905                910
Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro 
         915                920                925
Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu 
     930                935                940
Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr 
 945                950                955                960
Lys 
                 965



<210> 261
<211> 3202
<212> DNA
<213> Rattus norvegicus
<308> AB016161
<400> 261

agacacctc  ccgacgccc  cccagaagc  ttccccaga  gaagtgtcc  ccctgagct  60
cccccccac  ccaaggagg  cgcccccgc  cctcctcgc  atgggcccg  ggggaccct  120
taccccagt  gggtggccg  tgcctcttc  gctggtgat  gcggctggg  tggctccgg  180
gtgggcctc  cactcccct  atctcccgc  gcctcaccc  agggtcccc  cgcacccct  240
ctcagaacg  cgtgcagta  acatcgggg  gctgtttcc  atgagcggg  gctggccgg  300
gggccaggc  tgccagccc  cggtggaga  ggcgctgga  gacgttaac  gccgcagag  360
catcctgcc  gactacgag  tcaagctta  ccaccacga  agcaagtgt  acccagggc  420
agccaccaa  tacttgtac  aactactct  caatgaccc  atcaagatc  ttctcatgc  480
tggctgtag  tctgtctcc  cacttgtag  tgaggctgc  cggatgtgg  accttattg  540
gctctcata  ggctccagt  caccagcct  gtcaaaccg  cagcggttt  ccacgttct  600
ccggacgca  ccatccgcc  cactccaca  tcccacccg  gtgaaactc  tcgaaaagt  660
gggctggaa  aagatcgct  ccatccaac  gaccaccga  gtcttcacc  caacgctgg  720
tgacctgga  gagcgagtg  aagaggctg  gatcgagat  actttccga  agagtttct  780
ctcggatcc  gctgtgcct  ttaaaaacc  gaagcgtca  gatgctcga  tcatcgtgg  840
acttttcta  gagacggaa  cccggaaag  tttttgtga  gtctataag  aaaggctct  900
tgggaagaa  tacgtctgg  tcctcatcg  gtggtatgc  gacaactgg  tcaagacct  960
tgacccgtc  atcaattgt  cagtggaag  aatgaccga  gcggtggag  gccacatca  1020
cacggagat  gtcatgctg  accctgcca  cacccgaag  atttccaac  tgacgtcac  1080
ggaatttgt  gagaaacta  ccaagcggc  gaaaagaca  cccgaggag  ctggaggct  1140
ccaggaggc  ccactggcc  atgatgcta  ctgggcctt  gctttggcc  tgaacaaga  1200
gtctggagg  ggtggtcgt  ccggcgtgc  cctggagga  tttaactac  acaaccaga  1260
cattacaga  cagatctac  gggccatga  ctcctcctc  tttgagggc  tttctggcc  1320
tgtggtctt  gatgccagc  gctcccgga  ggcatggac  cttatcgag  agctacagg  1380
cggcagcta  aagaagatc  gctactacg  cagcaccaa  gatgatctt  cctggtcca  1440
aacggacaa  tggattgga  ggtctcccc  agctgacca  accttggtc  tcaagacat  1500
ccgtttcct  tctcagaaa  tctttatct  cgtctcagt  ctctccagc  tgggcattg  1560
tcttgctgt  gtctgtctg  cctttaaca  ctacaactc  cacgttcgt  atatccaga  1620
ctcccagcc  aacctgaac  atctgactg  tgtgggctg  tcactggca  tggctgctg  1680
cttccctct  gggctggat  gttaccaca  agggagaag  cagttcccg  ttgtctgcc  1740
ggcccgcct  tggctcttg  gcttgggct  tagtctggg  tatggctct  tgttcacca  1800
gatctggtg  gtccacaca  tcttcacga  gaaggagga  aagaaggag  ggaggaaga  1860
cctagagcc  tggaaactc  atgccactg  gggcctgct  gtgggcatg  atgtcctga  1920
tcttgccat  tggcagatt  tggacccct  gcaccgaac  attgagact  ttgccaagg  1980
ggaaccaaa  gaagacatc  atgtctcca  tctgcccca  ttggagcac  gcagctcca  2040
gaagatgaa  acgtggctt  gcattttct  tggttacaa  gggctgctg  tgctgctgg  2100
aatctttct  gcttacgaa  ccaagagcg  gtccactga  aagatcaat  accacaggg  2160
cgtgggcat  gctatctac  atgtcgcgg  cctgtgtct  atcactgct  ctgtgacca  2220
gatcctttc  agtcagcag  acgcagcct  tgcctttgc  tctctggcc  tcgtgttct  2280
ttcctacat  actctggtt  tgctctttg  gcccaagat  cgcaggctg  tcacccgag  2340
ggaatggca  tctgaaacg  aggacacca  gaaaacagg  tcatccacc  acaacaacg  2400
ggaagagaa  tcccgactg  tggagaagg  aaaccgaga  ctggaaaag  tcatcgctg  2460
ggtgtgcgg  gacaaacaa  cggggcccc  cgtgtctga  ggtgggttg  ccgtagtgg  2520
gccttcgat  gaggtttga  tgttggtgg  tcacagagg  tctcggcct  cagaggaac  2580
ggagaggga  aggggaagg  ttgagtttc  gtcccgtca  cccgaggag  gggaggggg  2640
ttctgcaga  ttcagccca  ctgaggcaa  agagcagtc  ctggcagta  ttaggggga  2700
gccattgtg  gacattggt  gcccacagt  ttactgtgt  cgggctgta  ttagggacc  2760
tgcagtgct  ggtgggggc  ggaaatggc  tttccactt  tctgatgca  tcttcattt  2820
ttccttttt  ttttttttt  aaatcactg  ttttctcca  ctattctct  ggtgccatt  2880
cgttctgtg  gcttccttt  ttctcccct  attcacatt  taatttcct  tctcactcg  2940
acatctcgt  tcatcgtct  cccccccct  cctccttcc  ttccacatc  ccctcctcc  3000
acactcccg  ttgtgtttc  tcctccaga  agaggagcg  gtctctgaa  tgcgccatc  3060
gctccagtc  cggcagcaa  tccgctcac  gcgccaccc  ccaacaccc  cagatccct  3120
tggaggcct  cccagggga  cctctgagc  ccctgaccg  cttagctgt  atgggagtc  3180
agtacattt  ctttacaag  ga  3202



<210> 262
<211> 991
<212> PRT
<213> Rattus norvegicus
<308> Q9Z0U4
<400> 262

Met Leu Leu Leu Leu Leu Val Pro Leu Phe Leu Arg Pro Leu Gly Ala 
  1               5                  10                  15
Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile Ile 
             20                  25                  30
His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg Asp 
         35                  40                  45
Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu Tyr 
     50                  55                  60
Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys Cys 
 65                  70                  75                  80
Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys Val 
                 85                  90                  95
Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val Phe 
             100                105                110
Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Glu Phe 
         115                120                125
Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Val Cys 
     130                135                140
Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn Arg 
 145                150                155                160
Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe Pro 
                 165                170                175
Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val Glu 
             180                185                190
Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp Tyr 
         195                200                205
Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln Ala 
     210                215                220
Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile Ile 
 225                230                235                240
Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala Ala 
                 245                250                255
Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro Ala 
             260                265                270
Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro Ser 
         275                280                285
Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp Gly 
     290                295                300
Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr Ser 
 305                310                315                320
Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu Ile 
                 325                330                335
Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys Asn 
             340                345                350
Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu Thr 
         355                360                365
Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe Gly 
     370                375                380
Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp Phe 
 385                390                395                400
Lys Thr Tyr Asp Pro Ser Ile Asn Cys Thr Val Glu Glu Met Thr Glu 
                 405                410                415
Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro Ala 
             420                425                430
Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu Lys 
         435                440                445
Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe Gln 
     450                455                460
Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala Leu 
 465                470                475                480
Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu Asp 
                 485                490                495
Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala Met 
             500                505                510
Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp Ala 
         515                520                525
Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly Gly 
     530                535                540
Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu Ser 
 545                550                555                560
Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp Gln 
                 565                570                575
Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe Ile 
             580                585                590
Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val Cys 
         595                600                605
Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn Ser 
     610                615                620
Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala Leu 
 625                630                635                640
Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg Ser 
                 645                650                655
Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu Gly 
             660                665                670
Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val His 
         675                680                685
Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr Leu 
     690                695                700
Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met Asp 
 705                710                715                720
Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg Thr 
                 725                730                735
Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val Ser 
             740                745                750
Ile Leu Pro Gln Leu Glu His Cys Ser Ser Lys Lys Met Asn Thr Trp 
         755                760                765
Leu Gly Glu Leu Trp Ser Phe Ala Val Ser Ser Asp Val Gln Arg Arg 
     770                775                780
Ala Thr Val Gly Gly Asp Ser Pro Ile Cys Val Trp Pro Ala Pro Glu 
 785                790                795                800
Ser Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly Ile Phe 
                 805                810                815
Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn Asp His 
             820                825                830
Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys Leu Ile 
         835                840                845
Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala Ala Phe 
     850                855                860
Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu Val 
 865                870                875                880
Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly Glu Trp 
                 885                890                895
Gln Ser Glu Thr Gln Asp Thr Met Lys Thr Gly Ser Ser Thr Asn Asn 
             900                905                910
Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu Leu 
         915                920                925
Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu Arg His 
     930                935                940
Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro Pro Thr 
 945                950                955                960
Pro Pro Asp Pro Ser Gly Gly Leu Pro Arg Gly Pro Ser Glu Pro Pro 
                 965                970                975
Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr Lys 
             980                985                990



<210> 263
<211> 4445
<212> DNA
<213> Homo sapiens
<308> AJ225028
<400> 263

cgctccccg  tcccgtggc  gccgccgcc  cggggaaga  gagacaggg  tggggtttg  60
gggaagcga  agaggaggg  agagaccct  gccaggctg  agcctggat  cgaggggag  120
agggacggg  ggaggagaa  ggtggagga  aagggaggg  ggagcgggg  ggagcggcc  180
ggcctgggg  cttgaggcc  ggggagagc  ggggagccg  gcccgcgcg  cgagatgtt  240
ctgctgctg  tactggcgc  actcttcct  cgccccccg  gcgcgggcg  ggcgcagac  300
cccaacgcc  cctcagaag  ttgccagat  atacacccg  cctgggaag  gggcatcag  360
taccggggc  tgactcggg  ccaggtgaa  gctatcaac  tcctgccag  ggactatga  420
attgagtat  tgtgccggg  ggagcgcga  gtggtgggg  ccaaggtcc  caagtgcct  480
gccaacggc  cctggacag  tatggacac  cccagccgc  gtgtccgaa  ctgctccaa  540
tcttatttg  ccctggaaa  tgggaaggt  ttcctgacg  gtggggacc  cccagctct  600
gacggagcc  gggtggatt  ccggtgtga  cccgacttc  atctggtgg  cagctcccg  660
agcatctgt  gtcagggcc  gtggagcac  cccaagccc  actgccagg  gaatcgaac  720
ccacactca  aacggcgcg  agtgtacat  ggggcactg  ttcccatga  cgggggctg  780
ccagggggc  aggcctgcc  gcccgcggt  gagatggcg  tggaggacg  gaatagccg  840
agggacatc  tgccggact  tgagctcaa  ctcatccac  acgacagca  gtgtgatcc  900
ggccaagcc  ccaagtacc  atatgagct  ctctacaac  accctatca  gatcatcct  960
atgcctggc  gcagctctg  ctccacgct  gtggctgag  ctgctagga  gtggaacct  1020
attgtgctt  cctatggct  cagctcacc  gccctgtca  accggcagc  tttccccac  1080
ttcttccga  cgcacccat  agccacact  cacaaccct  cccgcgtga  actctttga  1140
aagtggggc  ggaagaaga  tgctaccat  cagcagacc  ctgaggtct  cacttcgac  1200
ctggacgac  tggaggaac  agtgaagga  gctggaatt  agattactt  ccgccagag  1260
ttcttctca  atccagctg  gcccgtcaa  aacctgaag  gccaggatg  ccgaatcat  1320
gtgggactt  tctatgaga  tgaagcccg  aaagttttt  gtgaggtgt  caaggagcg  1380
ctctttggg  agaagtacg  ctggttcct  attgggtgg  atgctgaca  ttggttcaa  1440
atctacgac  cttctatca  ctgcacagt  gatgagatg  ctgaggcgg  ggagggcca  1500
atcacaact  agattgtca  gctgaatcc  gccaatacc  gcagcattt  caacatgac  1560
tcccaggaa  ttgtggaga  actaaccaa  cgactgaaa  gacaccctg  ggagacagg  1620
ggcttccag  aggcaccgc  ggcctatga  gccatctgg  ccttggcac  ggccctgaa  1680
aagacatct  gaggaggcg  ccgttctgg  gtgcgcctg  aggacttca  ctacaacaa  1740
cagaccatt  ccgaccaaa  ctaccgggc  atgaactct  cgtcctttg  gggtgtctc  1800
ggccatgtg  tgtttgatg  cagcggctc  cggatggca  ggacgctta  cgagcagct  1860
cagggtggc  gctacaaga  gattggcta  tatgacagc  ccaaggatg  tctttcctg  1920
tccaaaaca  ataaatgga  tggagggtc  cccccagct  accagaccc  ggtcatcaa  1980
acattccgc  tcctgtcac  gaaactctt  atctccgtc  cagttctct  cagcctggg  2040
attgtccta  ctgttgtct  tctgtcctt  aacatctac  actcacatg  ccgttatat  2100
cagaactca  agcccaacc  gaacaacct  actgctgtg  gctgctcac  ggctttagc  2160
gctgtcttc  ccctggggc  cgatggtta  cacattggg  ggaaccagt  tcctttcgt  2220
tgccaggcc  gcctctggc  cctgggcct  ggctttagt  tgggctacg  ttccatgtt  2280
accaagatt  ggtgggtcc  cacggtctt  acaaagaag  aagaaaaga  ggagtggag  2340
aagactctg  aaccctgga  gctgtatgc  acagtgggc  tgctggtgg  catggatgt  2400
ctcactctc  ccatctggc  gatcgtgga  cctctgcac  ggaccattg  gacatttgc  2460
aaggaggaa  ctaaggaag  tattgacgt  tctattctg  cccagctgg  gcattgcag  2520
tccaggaag  tgaatacat  gcttggcat  ttctatggt  acaaggggc  gctgctgct  2580
ctgggaatc  tccttgctt  tgagaccaa  agtgtgtcc  ctgagaaga  caatgatca  2640
cgggctgtg  gcatggcta  ctacaatgt  gcagtcctg  gcctcatca  tgctcctgt  2700
accatgatt  tgtccagcc  gcaggatgc  gcctttgcc  ttgcctctc  tgccatagt  2760
ttctcctcc  atatcactc  tgttgtgct  tttgtgccc  agatgcgca  gctgatcac  2820
cgaggggaa  ggcagtcgg  ggcgcagga  accatgaag  cagggtcat  gaccaacaa  2880
aacgaggag  agaagtccc  gctgttgga  aaggagaac  gtgaactgg  aaagatcat  2940
gctgagaaa  aggagcgtg  ctctgaact  cgccatcaa  tccagtctc  gcagcagct  3000
cgctcccgg  gccacccac  gacaccccc  gaaccctct  ggggcctgc  caggggacc  3060
cctgagccc  ccgaccggc  tagctgtga  gggagtcga  tgcatttgc  ttataagtg  3120
gggtagggt  agggaggac  ggccagtag  gggagggaa  gggagaggg  aagggcagg  3180
gactcagga  gcagggggt  cccatcccc  gctgggaag  acatgctat  caatctcat  3240
tcttgtaaa  acatgtccc  ctgtgagtt  tgggctgat  tgggtctct  atacctctg  3300
gaaacagac  tttttctct  ttactgctt  atgtaattt  gtatcacct  ttcacaatt  3360
agttcgtac  tggcttgaa  ctgctcact  ctcacacgc  gcctcctca  cagcctcac  3420
gcatctttc  cttcccatg  aacaccctc  tctagttac  acggcaacc  ctgcagctc  3480
tctgccttt  tgctctgtt  ctgtccagc  ggggtctcc  aacaagtgc  ctttccacc  3540
caaaggggc  tctcctttt  tccactgtc  taatctctt  ccatcttac  tgcccttct  3600
tactttctc  catgtggct  cccctgaat  ttgcttcct  tgggagctc  ttcttttcg  3660
caaggctca  atgctcctt  cctctgctc  gtgcactca  gctcagcac  catgcatcc  3720
cccctctcc  gcgtgtgcc  actgaacat  ctcatgtgt  cacacgctt  tcccgtatg  3780
tttcttcat  ttcagtcac  tgtgctctc  ggtgccctg  attcacagc  acgtgtgcc  3840
ctctcatgg  catgggtct  cccttgagc  tgtttgggt  ggcatgtgc  atttgtcta  3900
catgctgag  catgtcttt  ctatttgca  acgtccatg  ttatccatg  actttccct  3960
tgtaccctc  atgtacctt  tgtactttc  tcccttaaa  catggtatt  ttctgacag  4020
gccatatgt  ccctaccct  cacattgtt  tgcactttt  cccaattca  gtttggtgg  4080
gccatccac  ccctctcct  gtcacagaa  ctccatttc  gctcagatt  cccccatct  4140
cattgcatt  atgtactac  ctcagtcta  actcacaat  atcttctcc  aagactgct  4200
ccttttgtt  tgtgttttt  tgaggggaa  taaggaaaa  taagtgggg  caggtttgg  4260
gagctgctt  cagtggata  ttgatgaga  tcctgacca  aggaaggca  ccttgactg  4320
tgggataga  agatggacc  atggggtgg  aggtggtgt  cctttcaca  tgtggtgtc  4380
cttggggaa  gatctcccc  aatctcaat  aaccagtga  cagtgtgac  cggcaaaaa  4440
aaaaa  4445



<210> 264
<211> 961
<212> PRT
<213> Homo sapiens
<308> Q9UBS5
<400> 264

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
  1               5                  10                  15
Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
             20                  25                  30
Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
         35                  40                  45
Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
     50                  55                  60
Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
 65                  70                  75                  80
Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                 85                  90                  95
Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
             100                105                110
Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
         115                120                125
Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
     130                135                140
Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
 145                150                155                160
Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                 165                170                175
Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
             180                185                190
Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
         195                200                205
Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
     210                215                220
Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
 225                230                235                240
Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                 245                250                255
Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
             260                265                270
Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
         275                280                285
Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
     290                295                300
Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
 305                310                315                320
Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                 325                330                335
Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
             340                345                350
Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
         355                360                365
Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
     370                375                380
Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
 385                390                395                400
Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                 405                410                415
Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
             420                425                430
Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
         435                440                445
Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
     450                455                460
Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
 465                470                475                480
Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu 
                 485                490                495
Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
             500                505                510
Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
         515                520                525
Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
     530                535                540
Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
 545                550                555                560
Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp 
                 565                570                575
Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe 
             580                585                590
Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val 
         595                600                605
Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn 
     610                615                620
Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala 
 625                630                635                640
Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg 
                 645                650                655
Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu 
             660                665                670
Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val 
         675                680                685
His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr 
     690                695                700
Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met 
 705                710                715                720
Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg 
                 725                730                735
Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val 
             740                745                750
Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr 
         755                760                765
Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly 
     770                775                780
Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn 
 785                790                795                800
Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys 
                 805                810                815
Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala 
             820                825                830
Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr 
         835                840                845
Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly 
     850                855                860
Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr 
 865                870                875                880
Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg 
                 885                890                895
Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu 
             900                905                910
Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro 
         915                920                925
Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu 
     930                935                940
Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr 
 945                950                955                960
Lys 
                 965



<210> 265
<211> 2427
<212> DNA
<213> Rattus norvegicus
<308> AB016800
<400> 265

cgcacgcag  acctgcggt  ggcgatcag  tactgagaa  gctaccaag  ttgcctgct  60
tactcagca  ttgagccct  gtggaggtc  atctttctg  aaggatctg  gcctctcct  120
cttccctca  atcctgatg  cttcaaagt  ccagcacaa  gcttccaaa  ccaagaatc  180
caacgtcaa  gctgaatct  aaggacaat  gggccgtgc  tgggaagtg  actggttct  240
cctggtcag  gtcattttc  tgctgctct  cgcaccgtt  attgtgtac  acttcatca  300
ggcatgtga  cagtacagc  gctcgctga  tgcccccat  ttggacgta  ctacaggcc  360
tgcgagtct  gcagacatc  gggccaaga  accgcctgt  acagctaag  ctgcccaac  420
gtatgcctt  tgggtcagc  tccaggtgc  gctttactc  tggcttcct  acttctgcc  480
cagatttct  ccaggttat  tgggaggcg  ccaagaagg  gccataact  cagcaggga  540
tgtaaataa  tatgaggtg  atgggctgc  agcctggct  attacccac  tcctctggt  600
tgtgaacgc  tacctccta  cctggttct  ccccaccat  atctttgac  actggatcc  660
gttgctatg  tgtgccaac  tcctgggct  cgctgtgtc  acctttgca  tgatcaagg  720
gtacctgtt  cccaccagc  ccgaagact  caaattcac  ggcaatttc  tctacaact  780
catgatggg  attgagttc  acccccgca  cggaaagtg  tttgacttc  agctgttct  840
caatgggcg  ccggggatt  tggcctgga  tcttatcaa  ctgtccttt  ctgccaagc  900
gcaggagct  tatggccat  tgaccaact  catgatttt  gtcaatgtc  tacaggcca  960
ctatgtgtt  gacttcttc  ggaacgaaa  ctggtacct  aagaccatt  acatctgcc  1020
tgaccactt  ggatggtac  tgggctggg  agattgcgt  tggctgccc  acctctaca  1080
actgcaggg  ctgtacttg  tgtaccacc  tgtacagct  tccaccccc  acgccttgg  1140
cgtcctgct  ctcggcctg  tgggttact  tatcttccg  atgaccaac  atcagaagg  1200
cctgttccg  cggacagat  gacactgcc  catctgggg  aagaaaccc  aggccatcg  1260
gtgctccta  acgtcagcc  acgggctga  gcaccgcag  aagctgttg  tttcaggct  1320
ctggggtgt  gcccgccac  tcaactata  gggagacct  atgggcagc  tcgcctact  1380
cctggcttg  ggcggcggc  acctcctcc  ctacttcta  atcatctat  tgactatcc  1440
gcttaccca  cgctgcctc  gtgatgagc  ccgctgtgc  aacaagtat  gccgtgact  1500
ggagcgcta  gtagccgct  tgccctacc  cctgctgcc  gggatcttc  gagggccac  1560
ctggcaagc  gaaagaggc  tcattgaat  tgtggagtt  ggtgcatgg  ggccagcat  1620
cggctttcc  ctgcagggg  ctccttggt  tgctcttct  gaggatgga  agccaggcg  1680
cccacagtg  ctggctggt  gcaactaga  ctgagttca  actgatgcc  cagcagaat  1740
actggttct  cctgttcag  atcctgagg  cagaggacc  tggcccttt  atgtctgtt  1800
gaagcccac  atctatgtt  tctagatag  ttaggctta  caggtgtct  ccaggattg  1860
gccatcctg  taaactgga  acaatgtag  atctaaaga  ttttggcaa  gtcaccttc  1920
ctcccacct  caatggtgg  ctggacccc  ttttctgtc  gtagcgtga  cagcagagg  1980
ttcaggggc  attgaagga  gaaggctct  tgtttaggt  ctttactgt  tttacccga  2040
gaatgccaa  cagcagact  gaatatccc  ctctgcaca  ccctggctg  cttgataaa  2100
tctgtctga  atatgagat  gggttccca  aactcccca  gtaccccag  tagcagctt  2160
tccatctcc  ctcttccgg  aggtgcttc  tgtttaccc  tgagacttg  ctcagaggt  2220
aacagactt  gctctgaca  cccagaatg  atcaccagt  agtggcctc  gccacacct  2280
ccccaacag  agaaccagc  ttggggaag  aatccattc  cattagtga  actgccccc  2340
aaaactcag  gttattttg  aaaactaga  aggctcatg  tagccttgc  agcggttct  2400
tgtattaaa  ctgccctgt  aaatgag  2427



<210> 266
<211> 471
<212> PRT
<213> Rattus norvegicus
<308> BAA34306
<400> 266

Met Ala Ser Lys Ser Gln His Asn Ala Ser Lys Ala Lys Asn His Asn 
  1               5                  10                  15
Val Lys Ala Glu Ser Gln Gly Gln Trp Gly Arg Ala Trp Glu Val Asp 
             20                  25                  30
Trp Phe Ser Leu Val Ser Val Ile Phe Leu Leu Leu Phe Ala Pro Phe 
         35                  40                  45
Ile Val Tyr Tyr Phe Ile Met Ala Cys Asp Gln Tyr Ser Cys Ser Leu 
     50                  55                  60
Thr Ala Pro Ile Leu Asp Val Ala Thr Gly Arg Ala Ser Leu Ala Asp 
 65                  70                  75                  80
Ile Trp Ala Lys Thr Pro Pro Val Thr Ala Lys Ala Ala Gln Leu Tyr 
                 85                  90                  95
Ala Leu Trp Val Ser Phe Gln Val Leu Leu Tyr Ser Trp Leu Pro Asp 
             100                105                110
Phe Cys His Arg Phe Leu Pro Gly Tyr Val Gly Gly Val Gln Glu Gly 
         115                120                125
Ala Ile Thr Pro Ala Gly Ile Val Asn Lys Tyr Glu Val Asn Gly Leu 
     130                135                140
Gln Ala Trp Leu Ile Thr His Phe Leu Trp Phe Val Asn Ala Tyr Leu 
 145                150                155                160
Leu Ser Trp Phe Ser Pro Thr Ile Ile Phe Asp Asn Trp Ile Pro Leu 
                 165                170                175
Leu Trp Cys Ala Asn Ile Leu Gly Tyr Ala Val Ser Thr Phe Ala Met 
             180                185                190
Ile Lys Gly Tyr Leu Phe Pro Thr Ser Ala Glu Asp Cys Lys Phe Thr 
         195                200                205
Gly Asn Phe Phe Tyr Asn Tyr Met Met Gly Ile Glu Phe Asn Pro Arg 
     210                215                220
Ile Gly Lys Trp Phe Asp Phe Lys Leu Phe Phe Asn Gly Arg Pro Gly 
 225                230                235                240
Ile Val Ala Trp Thr Leu Ile Asn Leu Ser Phe Ala Ala Lys Gln Gln 
                 245                250                255
Glu Leu Tyr Gly His Val Thr Asn Ser Met Ile Leu Val Asn Val Leu 
             260                265                270
Gln Ala Ile Tyr Val Leu Asp Phe Phe Trp Asn Glu Thr Trp Tyr Leu 
         275                280                285
Lys Thr Ile Asp Ile Cys His Asp His Phe Gly Trp Tyr Leu Gly Trp 
     290                295                300
Gly Asp Cys Val Trp Leu Pro Tyr Leu Tyr Thr Leu Gln Gly Leu Tyr 
 305                310                315                320
Leu Val Tyr His Pro Val Gln Leu Ser Thr Pro Asn Ala Leu Gly Val 
                 325                330                335
Leu Leu Leu Gly Leu Val Gly Tyr Tyr Ile Phe Arg Met Thr Asn His 
             340                345                350
Gln Lys Asp Leu Phe Arg Arg Thr Asp Gly His Cys Leu Ile Trp Gly 
         355                360                365
Lys Lys Pro Lys Ala Ile Glu Cys Ser Tyr Thr Ser Ala Asp Gly Leu 
     370                375                380
Lys His Arg Ser Lys Leu Leu Val Ser Gly Phe Trp Gly Val Ala Arg 
 385                390                395                400
His Phe Asn Tyr Thr Gly Asp Leu Met Gly Ser Leu Ala Tyr Cys Leu 
                 405                410                415
Ala Cys Gly Gly Gly His Leu Leu Pro Tyr Phe Tyr Ile Ile Tyr Met 
             420                425                430
Thr Ile Leu Leu Thr His Arg Cys Leu Arg Asp Glu His Arg Cys Ala 
         435                440                445
Asn Lys Tyr Gly Arg Asp Trp Glu Arg Tyr Val Ala Ala Val Pro Tyr 
     450                455                460
Arg Leu Leu Pro Gly Ile Phe 
 465                470



<210> 267
<211> 2427
<212> DNA
<213> Rattus norvegicus
<308> AB016800
<400> 267

cgcacgcag  acctgcggt  ggcgatcag  tactgagaa  gctaccaag  ttgcctgct  60
tactcagca  ttgagccct  gtggaggtc  atctttctg  aaggatctg  gcctctcct  120
cttccctca  atcctgatg  cttcaaagt  ccagcacaa  gcttccaaa  ccaagaatc  180
caacgtcaa  gctgaatct  aaggacaat  gggccgtgc  tgggaagtg  actggttct  240
cctggtcag  gtcattttc  tgctgctct  cgcaccgtt  attgtgtac  acttcatca  300
ggcatgtga  cagtacagc  gctcgctga  tgcccccat  ttggacgta  ctacaggcc  360
tgcgagtct  gcagacatc  gggccaaga  accgcctgt  acagctaag  ctgcccaac  420
gtatgcctt  tgggtcagc  tccaggtgc  gctttactc  tggcttcct  acttctgcc  480
cagatttct  ccaggttat  tgggaggcg  ccaagaagg  gccataact  cagcaggga  540
tgtaaataa  tatgaggtg  atgggctgc  agcctggct  attacccac  tcctctggt  600
tgtgaacgc  tacctccta  cctggttct  ccccaccat  atctttgac  actggatcc  660
gttgctatg  tgtgccaac  tcctgggct  cgctgtgtc  acctttgca  tgatcaagg  720
gtacctgtt  cccaccagc  ccgaagact  caaattcac  ggcaatttc  tctacaact  780
catgatggg  attgagttc  acccccgca  cggaaagtg  tttgacttc  agctgttct  840
caatgggcg  ccggggatt  tggcctgga  tcttatcaa  ctgtccttt  ctgccaagc  900
gcaggagct  tatggccat  tgaccaact  catgatttt  gtcaatgtc  tacaggcca  960
ctatgtgtt  gacttcttc  ggaacgaaa  ctggtacct  aagaccatt  acatctgcc  1020
tgaccactt  ggatggtac  tgggctggg  agattgcgt  tggctgccc  acctctaca  1080
actgcaggg  ctgtacttg  tgtaccacc  tgtacagct  tccaccccc  acgccttgg  1140
cgtcctgct  ctcggcctg  tgggttact  tatcttccg  atgaccaac  atcagaagg  1200
cctgttccg  cggacagat  gacactgcc  catctgggg  aagaaaccc  aggccatcg  1260
gtgctccta  acgtcagcc  acgggctga  gcaccgcag  aagctgttg  tttcaggct  1320
ctggggtgt  gcccgccac  tcaactata  gggagacct  atgggcagc  tcgcctact  1380
cctggcttg  ggcggcggc  acctcctcc  ctacttcta  atcatctat  tgactatcc  1440
gcttaccca  cgctgcctc  gtgatgagc  ccgctgtgc  aacaagtat  gccgtgact  1500
ggagcgcta  gtagccgct  tgccctacc  cctgctgcc  gggatcttc  gagggccac  1560
ctggcaagc  gaaagaggc  tcattgaat  tgtggagtt  ggtgcatgg  ggccagcat  1620
cggctttcc  ctgcagggg  ctccttggt  tgctcttct  gaggatgga  agccaggcg  1680
cccacagtg  ctggctggt  gcaactaga  ctgagttca  actgatgcc  cagcagaat  1740
actggttct  cctgttcag  atcctgagg  cagaggacc  tggcccttt  atgtctgtt  1800
gaagcccac  atctatgtt  tctagatag  ttaggctta  caggtgtct  ccaggattg  1860
gccatcctg  taaactgga  acaatgtag  atctaaaga  ttttggcaa  gtcaccttc  1920
ctcccacct  caatggtgg  ctggacccc  ttttctgtc  gtagcgtga  cagcagagg  1980
ttcaggggc  attgaagga  gaaggctct  tgtttaggt  ctttactgt  tttacccga  2040
gaatgccaa  cagcagact  gaatatccc  ctctgcaca  ccctggctg  cttgataaa  2100
tctgtctga  atatgagat  gggttccca  aactcccca  gtaccccag  tagcagctt  2160
tccatctcc  ctcttccgg  aggtgcttc  tgtttaccc  tgagacttg  ctcagaggt  2220
aacagactt  gctctgaca  cccagaatg  atcaccagt  agtggcctc  gccacacct  2280
ccccaacag  agaaccagc  ttggggaag  aatccattc  cattagtga  actgccccc  2340
aaaactcag  gttattttg  aaaactaga  aggctcatg  tagccttgc  agcggttct  2400
tgtattaaa  ctgccctgt  aaatgag  2427



<210> 268
<211> 471
<212> PRT
<213> Rattus norvegicus
<308> BAA34306
<400> 268

Met Ala Ser Lys Ser Gln His Asn Ala Ser Lys Ala Lys Asn His Asn 
  1               5                  10                  15
Val Lys Ala Glu Ser Gln Gly Gln Trp Gly Arg Ala Trp Glu Val Asp 
             20                  25                  30
Trp Phe Ser Leu Val Ser Val Ile Phe Leu Leu Leu Phe Ala Pro Phe 
         35                  40                  45
Ile Val Tyr Tyr Phe Ile Met Ala Cys Asp Gln Tyr Ser Cys Ser Leu 
     50                  55                  60
Thr Ala Pro Ile Leu Asp Val Ala Thr Gly Arg Ala Ser Leu Ala Asp 
 65                  70                  75                  80
Ile Trp Ala Lys Thr Pro Pro Val Thr Ala Lys Ala Ala Gln Leu Tyr 
                 85                  90                  95
Ala Leu Trp Val Ser Phe Gln Val Leu Leu Tyr Ser Trp Leu Pro Asp 
             100                105                110
Phe Cys His Arg Phe Leu Pro Gly Tyr Val Gly Gly Val Gln Glu Gly 
         115                120                125
Ala Ile Thr Pro Ala Gly Ile Val Asn Lys Tyr Glu Val Asn Gly Leu 
     130                135                140
Gln Ala Trp Leu Ile Thr His Phe Leu Trp Phe Val Asn Ala Tyr Leu 
 145                150                155                160
Leu Ser Trp Phe Ser Pro Thr Ile Ile Phe Asp Asn Trp Ile Pro Leu 
                 165                170                175
Leu Trp Cys Ala Asn Ile Leu Gly Tyr Ala Val Ser Thr Phe Ala Met 
             180                185                190
Ile Lys Gly Tyr Leu Phe Pro Thr Ser Ala Glu Asp Cys Lys Phe Thr 
         195                200                205
Gly Asn Phe Phe Tyr Asn Tyr Met Met Gly Ile Glu Phe Asn Pro Arg 
     210                215                220
Ile Gly Lys Trp Phe Asp Phe Lys Leu Phe Phe Asn Gly Arg Pro Gly 
 225                230                235                240
Ile Val Ala Trp Thr Leu Ile Asn Leu Ser Phe Ala Ala Lys Gln Gln 
                 245                250                255
Glu Leu Tyr Gly His Val Thr Asn Ser Met Ile Leu Val Asn Val Leu 
             260                265                270
Gln Ala Ile Tyr Val Leu Asp Phe Phe Trp Asn Glu Thr Trp Tyr Leu 
         275                280                285
Lys Thr Ile Asp Ile Cys His Asp His Phe Gly Trp Tyr Leu Gly Trp 
     290                295                300
Gly Asp Cys Val Trp Leu Pro Tyr Leu Tyr Thr Leu Gln Gly Leu Tyr 
 305                310                315                320
Leu Val Tyr His Pro Val Gln Leu Ser Thr Pro Asn Ala Leu Gly Val 
                 325                330                335
Leu Leu Leu Gly Leu Val Gly Tyr Tyr Ile Phe Arg Met Thr Asn His 
             340                345                350
Gln Lys Asp Leu Phe Arg Arg Thr Asp Gly His Cys Leu Ile Trp Gly 
         355                360                365
Lys Lys Pro Lys Ala Ile Glu Cys Ser Tyr Thr Ser Ala Asp Gly Leu 
     370                375                380
Lys His Arg Ser Lys Leu Leu Val Ser Gly Phe Trp Gly Val Ala Arg 
 385                390                395                400
His Phe Asn Tyr Thr Gly Asp Leu Met Gly Ser Leu Ala Tyr Cys Leu 
                 405                410                415
Ala Cys Gly Gly Gly His Leu Leu Pro Tyr Phe Tyr Ile Ile Tyr Met 
             420                425                430
Thr Ile Leu Leu Thr His Arg Cys Leu Arg Asp Glu His Arg Cys Ala 
         435                440                445
Asn Lys Tyr Gly Arg Asp Trp Glu Arg Tyr Val Ala Ala Val Pro Tyr 
     450                455                460
Arg Leu Leu Pro Gly Ile Phe 
 465                470



<210> 269
<211> 2427
<212> DNA
<213> Rattus norvegicus
<308> AB016800
<400> 269

cgcacgcag  acctgcggt  ggcgatcag  tactgagaa  gctaccaag  ttgcctgct  60
tactcagca  ttgagccct  gtggaggtc  atctttctg  aaggatctg  gcctctcct  120
cttccctca  atcctgatg  cttcaaagt  ccagcacaa  gcttccaaa  ccaagaatc  180
caacgtcaa  gctgaatct  aaggacaat  gggccgtgc  tgggaagtg  actggttct  240
cctggtcag  gtcattttc  tgctgctct  cgcaccgtt  attgtgtac  acttcatca  300
ggcatgtga  cagtacagc  gctcgctga  tgcccccat  ttggacgta  ctacaggcc  360
tgcgagtct  gcagacatc  gggccaaga  accgcctgt  acagctaag  ctgcccaac  420
gtatgcctt  tgggtcagc  tccaggtgc  gctttactc  tggcttcct  acttctgcc  480
cagatttct  ccaggttat  tgggaggcg  ccaagaagg  gccataact  cagcaggga  540
tgtaaataa  tatgaggtg  atgggctgc  agcctggct  attacccac  tcctctggt  600
tgtgaacgc  tacctccta  cctggttct  ccccaccat  atctttgac  actggatcc  660
gttgctatg  tgtgccaac  tcctgggct  cgctgtgtc  acctttgca  tgatcaagg  720
gtacctgtt  cccaccagc  ccgaagact  caaattcac  ggcaatttc  tctacaact  780
catgatggg  attgagttc  acccccgca  cggaaagtg  tttgacttc  agctgttct  840
caatgggcg  ccggggatt  tggcctgga  tcttatcaa  ctgtccttt  ctgccaagc  900
gcaggagct  tatggccat  tgaccaact  catgatttt  gtcaatgtc  tacaggcca  960
ctatgtgtt  gacttcttc  ggaacgaaa  ctggtacct  aagaccatt  acatctgcc  1020
tgaccactt  ggatggtac  tgggctggg  agattgcgt  tggctgccc  acctctaca  1080
actgcaggg  ctgtacttg  tgtaccacc  tgtacagct  tccaccccc  acgccttgg  1140
cgtcctgct  ctcggcctg  tgggttact  tatcttccg  atgaccaac  atcagaagg  1200
cctgttccg  cggacagat  gacactgcc  catctgggg  aagaaaccc  aggccatcg  1260
gtgctccta  acgtcagcc  acgggctga  gcaccgcag  aagctgttg  tttcaggct  1320
ctggggtgt  gcccgccac  tcaactata  gggagacct  atgggcagc  tcgcctact  1380
cctggcttg  ggcggcggc  acctcctcc  ctacttcta  atcatctat  tgactatcc  1440
gcttaccca  cgctgcctc  gtgatgagc  ccgctgtgc  aacaagtat  gccgtgact  1500
ggagcgcta  gtagccgct  tgccctacc  cctgctgcc  gggatcttc  gagggccac  1560
ctggcaagc  gaaagaggc  tcattgaat  tgtggagtt  ggtgcatgg  ggccagcat  1620
cggctttcc  ctgcagggg  ctccttggt  tgctcttct  gaggatgga  agccaggcg  1680
cccacagtg  ctggctggt  gcaactaga  ctgagttca  actgatgcc  cagcagaat  1740
actggttct  cctgttcag  atcctgagg  cagaggacc  tggcccttt  atgtctgtt  1800
gaagcccac  atctatgtt  tctagatag  ttaggctta  caggtgtct  ccaggattg  1860
gccatcctg  taaactgga  acaatgtag  atctaaaga  ttttggcaa  gtcaccttc  1920
ctcccacct  caatggtgg  ctggacccc  ttttctgtc  gtagcgtga  cagcagagg  1980
ttcaggggc  attgaagga  gaaggctct  tgtttaggt  ctttactgt  tttacccga  2040
gaatgccaa  cagcagact  gaatatccc  ctctgcaca  ccctggctg  cttgataaa  2100
tctgtctga  atatgagat  gggttccca  aactcccca  gtaccccag  tagcagctt  2160
tccatctcc  ctcttccgg  aggtgcttc  tgtttaccc  tgagacttg  ctcagaggt  2220
aacagactt  gctctgaca  cccagaatg  atcaccagt  agtggcctc  gccacacct  2280
ccccaacag  agaaccagc  ttggggaag  aatccattc  cattagtga  actgccccc  2340
aaaactcag  gttattttg  aaaactaga  aggctcatg  tagccttgc  agcggttct  2400
tgtattaaa  ctgccctgt  aaatgag  2427



<210> 270
<211> 471
<212> PRT
<213> Rattus norvegicus
<308> BAA34306
<400> 270

Met Ala Ser Lys Ser Gln His Asn Ala Ser Lys Ala Lys Asn His Asn 
  1               5                  10                  15
Val Lys Ala Glu Ser Gln Gly Gln Trp Gly Arg Ala Trp Glu Val Asp 
             20                  25                  30
Trp Phe Ser Leu Val Ser Val Ile Phe Leu Leu Leu Phe Ala Pro Phe 
         35                  40                  45
Ile Val Tyr Tyr Phe Ile Met Ala Cys Asp Gln Tyr Ser Cys Ser Leu 
     50                  55                  60
Thr Ala Pro Ile Leu Asp Val Ala Thr Gly Arg Ala Ser Leu Ala Asp 
 65                  70                  75                  80
Ile Trp Ala Lys Thr Pro Pro Val Thr Ala Lys Ala Ala Gln Leu Tyr 
                 85                  90                  95
Ala Leu Trp Val Ser Phe Gln Val Leu Leu Tyr Ser Trp Leu Pro Asp 
             100                105                110
Phe Cys His Arg Phe Leu Pro Gly Tyr Val Gly Gly Val Gln Glu Gly 
         115                120                125
Ala Ile Thr Pro Ala Gly Ile Val Asn Lys Tyr Glu Val Asn Gly Leu 
     130                135                140
Gln Ala Trp Leu Ile Thr His Phe Leu Trp Phe Val Asn Ala Tyr Leu 
 145                150                155                160
Leu Ser Trp Phe Ser Pro Thr Ile Ile Phe Asp Asn Trp Ile Pro Leu 
                 165                170                175
Leu Trp Cys Ala Asn Ile Leu Gly Tyr Ala Val Ser Thr Phe Ala Met 
             180                185                190
Ile Lys Gly Tyr Leu Phe Pro Thr Ser Ala Glu Asp Cys Lys Phe Thr 
         195                200                205
Gly Asn Phe Phe Tyr Asn Tyr Met Met Gly Ile Glu Phe Asn Pro Arg 
     210                215                220
Ile Gly Lys Trp Phe Asp Phe Lys Leu Phe Phe Asn Gly Arg Pro Gly 
 225                230                235                240
Ile Val Ala Trp Thr Leu Ile Asn Leu Ser Phe Ala Ala Lys Gln Gln 
                 245                250                255
Glu Leu Tyr Gly His Val Thr Asn Ser Met Ile Leu Val Asn Val Leu 
             260                265                270
Gln Ala Ile Tyr Val Leu Asp Phe Phe Trp Asn Glu Thr Trp Tyr Leu 
         275                280                285
Lys Thr Ile Asp Ile Cys His Asp His Phe Gly Trp Tyr Leu Gly Trp 
     290                295                300
Gly Asp Cys Val Trp Leu Pro Tyr Leu Tyr Thr Leu Gln Gly Leu Tyr 
 305                310                315                320
Leu Val Tyr His Pro Val Gln Leu Ser Thr Pro Asn Ala Leu Gly Val 
                 325                330                335
Leu Leu Leu Gly Leu Val Gly Tyr Tyr Ile Phe Arg Met Thr Asn His 
             340                345                350
Gln Lys Asp Leu Phe Arg Arg Thr Asp Gly His Cys Leu Ile Trp Gly 
         355                360                365
Lys Lys Pro Lys Ala Ile Glu Cys Ser Tyr Thr Ser Ala Asp Gly Leu 
     370                375                380
Lys His Arg Ser Lys Leu Leu Val Ser Gly Phe Trp Gly Val Ala Arg 
 385                390                395                400
His Phe Asn Tyr Thr Gly Asp Leu Met Gly Ser Leu Ala Tyr Cys Leu 
                 405                410                415
Ala Cys Gly Gly Gly His Leu Leu Pro Tyr Phe Tyr Ile Ile Tyr Met 
             420                425                430
Thr Ile Leu Leu Thr His Arg Cys Leu Arg Asp Glu His Arg Cys Ala 
         435                440                445
Asn Lys Tyr Gly Arg Asp Trp Glu Arg Tyr Val Ala Ala Val Pro Tyr 
     450                455                460
Arg Leu Leu Pro Gly Ile Phe 
 465                470



<210> 271
<211> 2427
<212> DNA
<213> Rattus norvegicus
<308> AB016800
<400> 271

cgcacgcag  acctgcggt  ggcgatcag  tactgagaa  gctaccaag  ttgcctgct  60
tactcagca  ttgagccct  gtggaggtc  atctttctg  aaggatctg  gcctctcct  120
cttccctca  atcctgatg  cttcaaagt  ccagcacaa  gcttccaaa  ccaagaatc  180
caacgtcaa  gctgaatct  aaggacaat  gggccgtgc  tgggaagtg  actggttct  240
cctggtcag  gtcattttc  tgctgctct  cgcaccgtt  attgtgtac  acttcatca  300
ggcatgtga  cagtacagc  gctcgctga  tgcccccat  ttggacgta  ctacaggcc  360
tgcgagtct  gcagacatc  gggccaaga  accgcctgt  acagctaag  ctgcccaac  420
gtatgcctt  tgggtcagc  tccaggtgc  gctttactc  tggcttcct  acttctgcc  480
cagatttct  ccaggttat  tgggaggcg  ccaagaagg  gccataact  cagcaggga  540
tgtaaataa  tatgaggtg  atgggctgc  agcctggct  attacccac  tcctctggt  600
tgtgaacgc  tacctccta  cctggttct  ccccaccat  atctttgac  actggatcc  660
gttgctatg  tgtgccaac  tcctgggct  cgctgtgtc  acctttgca  tgatcaagg  720
gtacctgtt  cccaccagc  ccgaagact  caaattcac  ggcaatttc  tctacaact  780
catgatggg  attgagttc  acccccgca  cggaaagtg  tttgacttc  agctgttct  840
caatgggcg  ccggggatt  tggcctgga  tcttatcaa  ctgtccttt  ctgccaagc  900
gcaggagct  tatggccat  tgaccaact  catgatttt  gtcaatgtc  tacaggcca  960
ctatgtgtt  gacttcttc  ggaacgaaa  ctggtacct  aagaccatt  acatctgcc  1020
tgaccactt  ggatggtac  tgggctggg  agattgcgt  tggctgccc  acctctaca  1080
actgcaggg  ctgtacttg  tgtaccacc  tgtacagct  tccaccccc  acgccttgg  1140
cgtcctgct  ctcggcctg  tgggttact  tatcttccg  atgaccaac  atcagaagg  1200
cctgttccg  cggacagat  gacactgcc  catctgggg  aagaaaccc  aggccatcg  1260
gtgctccta  acgtcagcc  acgggctga  gcaccgcag  aagctgttg  tttcaggct  1320
ctggggtgt  gcccgccac  tcaactata  gggagacct  atgggcagc  tcgcctact  1380
cctggcttg  ggcggcggc  acctcctcc  ctacttcta  atcatctat  tgactatcc  1440
gcttaccca  cgctgcctc  gtgatgagc  ccgctgtgc  aacaagtat  gccgtgact  1500
ggagcgcta  gtagccgct  tgccctacc  cctgctgcc  gggatcttc  gagggccac  1560
ctggcaagc  gaaagaggc  tcattgaat  tgtggagtt  ggtgcatgg  ggccagcat  1620
cggctttcc  ctgcagggg  ctccttggt  tgctcttct  gaggatgga  agccaggcg  1680
cccacagtg  ctggctggt  gcaactaga  ctgagttca  actgatgcc  cagcagaat  1740
actggttct  cctgttcag  atcctgagg  cagaggacc  tggcccttt  atgtctgtt  1800
gaagcccac  atctatgtt  tctagatag  ttaggctta  caggtgtct  ccaggattg  1860
gccatcctg  taaactgga  acaatgtag  atctaaaga  ttttggcaa  gtcaccttc  1920
ctcccacct  caatggtgg  ctggacccc  ttttctgtc  gtagcgtga  cagcagagg  1980
ttcaggggc  attgaagga  gaaggctct  tgtttaggt  ctttactgt  tttacccga  2040
gaatgccaa  cagcagact  gaatatccc  ctctgcaca  ccctggctg  cttgataaa  2100
tctgtctga  atatgagat  gggttccca  aactcccca  gtaccccag  tagcagctt  2160
tccatctcc  ctcttccgg  aggtgcttc  tgtttaccc  tgagacttg  ctcagaggt  2220
aacagactt  gctctgaca  cccagaatg  atcaccagt  agtggcctc  gccacacct  2280
ccccaacag  agaaccagc  ttggggaag  aatccattc  cattagtga  actgccccc  2340
aaaactcag  gttattttg  aaaactaga  aggctcatg  tagccttgc  agcggttct  2400
tgtattaaa  ctgccctgt  aaatgag  2427



<210> 272
<211> 471
<212> PRT
<213> Rattus norvegicus
<308> BAA34306
<400> 272

Met Ala Ser Lys Ser Gln His Asn Ala Ser Lys Ala Lys Asn His Asn 
  1               5                  10                  15
Val Lys Ala Glu Ser Gln Gly Gln Trp Gly Arg Ala Trp Glu Val Asp 
             20                  25                  30
Trp Phe Ser Leu Val Ser Val Ile Phe Leu Leu Leu Phe Ala Pro Phe 
         35                  40                  45
Ile Val Tyr Tyr Phe Ile Met Ala Cys Asp Gln Tyr Ser Cys Ser Leu 
     50                  55                  60
Thr Ala Pro Ile Leu Asp Val Ala Thr Gly Arg Ala Ser Leu Ala Asp 
 65                  70                  75                  80
Ile Trp Ala Lys Thr Pro Pro Val Thr Ala Lys Ala Ala Gln Leu Tyr 
                 85                  90                  95
Ala Leu Trp Val Ser Phe Gln Val Leu Leu Tyr Ser Trp Leu Pro Asp 
             100                105                110
Phe Cys His Arg Phe Leu Pro Gly Tyr Val Gly Gly Val Gln Glu Gly 
         115                120                125
Ala Ile Thr Pro Ala Gly Ile Val Asn Lys Tyr Glu Val Asn Gly Leu 
     130                135                140
Gln Ala Trp Leu Ile Thr His Phe Leu Trp Phe Val Asn Ala Tyr Leu 
 145                150                155                160
Leu Ser Trp Phe Ser Pro Thr Ile Ile Phe Asp Asn Trp Ile Pro Leu 
                 165                170                175
Leu Trp Cys Ala Asn Ile Leu Gly Tyr Ala Val Ser Thr Phe Ala Met 
             180                185                190
Ile Lys Gly Tyr Leu Phe Pro Thr Ser Ala Glu Asp Cys Lys Phe Thr 
         195                200                205
Gly Asn Phe Phe Tyr Asn Tyr Met Met Gly Ile Glu Phe Asn Pro Arg 
     210                215                220
Ile Gly Lys Trp Phe Asp Phe Lys Leu Phe Phe Asn Gly Arg Pro Gly 
 225                230                235                240
Ile Val Ala Trp Thr Leu Ile Asn Leu Ser Phe Ala Ala Lys Gln Gln 
                 245                250                255
Glu Leu Tyr Gly His Val Thr Asn Ser Met Ile Leu Val Asn Val Leu 
             260                265                270
Gln Ala Ile Tyr Val Leu Asp Phe Phe Trp Asn Glu Thr Trp Tyr Leu 
         275                280                285
Lys Thr Ile Asp Ile Cys His Asp His Phe Gly Trp Tyr Leu Gly Trp 
     290                295                300
Gly Asp Cys Val Trp Leu Pro Tyr Leu Tyr Thr Leu Gln Gly Leu Tyr 
 305                310                315                320
Leu Val Tyr His Pro Val Gln Leu Ser Thr Pro Asn Ala Leu Gly Val 
                 325                330                335
Leu Leu Leu Gly Leu Val Gly Tyr Tyr Ile Phe Arg Met Thr Asn His 
             340                345                350
Gln Lys Asp Leu Phe Arg Arg Thr Asp Gly His Cys Leu Ile Trp Gly 
         355                360                365
Lys Lys Pro Lys Ala Ile Glu Cys Ser Tyr Thr Ser Ala Asp Gly Leu 
     370                375                380
Lys His Arg Ser Lys Leu Leu Val Ser Gly Phe Trp Gly Val Ala Arg 
 385                390                395                400
His Phe Asn Tyr Thr Gly Asp Leu Met Gly Ser Leu Ala Tyr Cys Leu 
                 405                410                415
Ala Cys Gly Gly Gly His Leu Leu Pro Tyr Phe Tyr Ile Ile Tyr Met 
             420                425                430
Thr Ile Leu Leu Thr His Arg Cys Leu Arg Asp Glu His Arg Cys Ala 
         435                440                445
Asn Lys Tyr Gly Arg Asp Trp Glu Arg Tyr Val Ala Ala Val Pro Tyr 
     450                455                460
Arg Leu Leu Pro Gly Ile Phe 
 465                470



<210> 273
<211> 591
<212> DNA
<213> Rattus norvegicus
<308> AB017170
<400> 273

cattgcagt  gagctgtac  agggccatg  ccgtgttag  tacgaccca  gcagctacc  60
cagctctgc  atctacagt  ctgaaacaa  caacgatgg  cagttccac  cagttgagc  120
ggtgacctt  gaccagatg  tgaacctct  catcgatgg  ggcagcccc  tgaccatgg  180
caactttgg  aagcactac  cactcaaca  tgaggcccc  ctctatgtg  gagggatgc  240
cgtggatgt  aactcagct  ccttccgcc  gtggcagat  ctcaatggc  ccagcttcc  300
cggttgcat  cggaatcta  acatcaaca  cgaactgca  gacttcacc  agacacaga  360
gaagccggg  gtggtgccc  gctgcgagc  ctgccgaaa  ctctactgt  tacatggca  420
ttgccagcc  aacgccacc  cagggcccg  gtgccactg  gaggctggc  gggggggcc  480
gcactgtga  cagccagtg  acggcccct  ccatggcca  aagtgtgtc  atgggaaat  540
cgtgcccct  gatgcactt  cctacagct  ccagtgcca  gatgggtac  c  591



<210> 274
<211> 196
<212> PRT
<213> Rattus norvegicus
<308> BAA35187
<400> 274

Ile Ala Val Glu Leu Tyr Gln Gly His Val Arg Val Ser Tyr Asp Pro 
  1               5                  10                  15
Gly Ser Tyr Pro Ser Ser Ala Ile Tyr Ser Ala Glu Thr Ile Asn Asp 
             20                  25                  30
Gly Gln Phe His Thr Val Glu Leu Val Thr Phe Asp Gln Met Val Asn 
         35                  40                  45
Leu Ser Ile Asp Gly Gly Ser Pro Met Thr Met Asp Asn Phe Gly Lys 
     50                  55                  60
His Tyr Thr Leu Asn Ser Glu Ala Pro Leu Tyr Val Gly Gly Met Pro 
 65                  70                  75                  80
Val Asp Val Asn Ser Ala Ala Phe Arg Leu Trp Gln Ile Leu Asn Gly 
                 85                  90                  95
Thr Ser Phe His Gly Cys Ile Arg Asn Leu Tyr Ile Asn Asn Glu Leu 
             100                105                110
Gln Asp Phe Thr Lys Thr Gln Met Lys Pro Gly Val Val Pro Gly Cys 
         115                120                125
Glu Pro Cys Arg Lys Leu Tyr Cys Leu His Gly Ile Cys Gln Pro Asn 
     130                135                140
Ala Thr Pro Gly Pro Val Cys His Cys Glu Ala Gly Trp Gly Gly Leu 
 145                150                155                160
His Cys Asp Gln Pro Val Asp Gly Pro Cys His Gly His Lys Cys Val 
                 165                170                175
His Gly Lys Cys Val Pro Leu Asp Ala Leu Ala Tyr Ser Cys Gln Cys 
             180                185                190
Gln Asp Gly Tyr 
         195



<210> 275
<211> 5094
<212> DNA
<213> Homo sapiens
<308> AB017167
<400> 275

gcgaaacgg  agaggagcc  agccccctc  gcccaaggc  ccctccctc  gtccgcgca  60
aggcgccgt  gcttggagg  gcaaggtgc  tcccagccc  caggggcgc  gcgcgcaag  120
ccgcgggct  ttcggtggc  ctgccccgg  actgcacct  gaggcggcc  cggacgggg  180
tggtcagcg  ctgctgccg  ctggctcgc  agcgggacg  tgtgagggc  ccatggcgc  240
gactcccgg  tgggggtcc  cggcggggc  ggtccggcc  gagctctgg  tgctgctgt  300
ggcagccgc  tggcgcctg  gtgcctcgg  gtgccccgc  ctctgcacc  gcaccggaa  360
cacggtgga  tgccacggc  cggggctgc  ggccattcc  aagaatata  ctcggaaca  420
cgagcgcct  gaactcaat  gcaacaaca  cactcggat  cataagaat  actttgcgg  480
gctcaagca  ctgcgggtg  tgcagctga  ggagaacca  attggagca  tggaacgtg  540
tgcttttga  gacatgaag  agctggagc  gctgcgact  aaccgaaac  agctgcaca  600
gttaccgga  ctgctgttc  agaacaacc  ggctttgtc  agactggac  tgagtgaga  660
cgccatcca  gccatcccc  ggaaagctt  tcggggagc  acggacctt  aaaatttac  720
gctggacaa  aaccagatc  gctgcattg  ggaaggggc  ttccgtgct  tgcgggggc  780
ggaggtgct  accctgaac  acaacaata  caccaccat  cccgtgtcc  gcttcaacc  840
tatgcccaa  ctacggacc  tccgcctgc  ctccaacca  ctgttttgc  actgccacc  900
ggcctggct  tcgcagtgg  tgaggcagc  gccaaccat  gggctcttc  cccagtgct  960
gggcccagc  agcctgcgt  gcctcaatg  ggcagaggt  cagaagagt  agttcagct  1020
ctcaggcca  ggagaagcg  ggcgcgtgc  cacctgcac  ctgtcctcc  gctcctgcc  1080
ggccatgtg  acctgcagc  atggcatcg  ggactgtcg  ggaaaaggc  tcactgcca  1140
cccggccaa  ctgcccgag  ccatgacgg  gatacgcct  gagctgaac  gcatcaagt  1200
catccctcc  ggagccttc  caccctaca  aaagctacg  aggatagac  tgagcaaca  1260
tcagatcgc  gagattgca  ccgacgcct  ccagggcct  cgctccctg  actcgctgg  1320
cctctatgg  aacaagatc  cagacctcc  ccgtggtgt  tttggaggc  tatacaccc  1380
acagctcct  ctcctgaat  ccaacaaga  caactgcat  cggcccgat  ccttccagg  1440
cctgcagaa  ctctcactg  tctccctgt  tgacaacaa  atccagagc  tcgccaagg  1500
cactttcac  tccctgcgg  ccatccaga  tctgcacct  gcccagaac  ctttcattt  1560
cgactgtaa  ctcaagtgg  tggcagact  cctgcgcac  aatcccatc  agacgagtg  1620
tgcccgctg  gccagtccc  ggcgcctcg  caacaagcg  atcgggcag  tcaagagca  1680
gaagttccg  tgctcagcc  aagagcagt  cttcattcc  ggcacggag  attaccagc  1740
gaacagcga  tgcaacagc  acgtggtct  tccccacaa  tgccgctgt  aggccaacg  1800
ggtggagtg  tccagcctg  agctcacca  gatccctga  cgcatcccc  agtccacgg  1860
agaactgcg  ttgaataac  atgagattt  catcctgga  gccactggg  tgtttaaaa  1920
acttacaca  ctgaagaaa  tcaatctga  caacaacaa  gtgtcagaa  ttgaagatg  1980
ggccttcga  ggcgcagcc  ctgtgagcg  gctgcacct  actgccaac  agctggagt  2040
catccggag  ggcatgttc  ggggtctgg  tggcttgag  accctaatg  tgcggaaca  2100
ccgcatcag  tgcatccac  acgacagct  cacgggcct  cgcaacgtc  ggctcctct  2160
gctctacga  aaccagatc  ccaccgtat  cccaggagc  ttcgacacc  tccagtccc  2220
ctccacact  aatctcctg  ccaaccctt  caactgcaa  tgccagctg  cctggctag  2280
aggctggct  cggaagcgc  agatcgtga  ggggaaccc  cgatgccag  accctgact  2340
tttgcggca  attcccctg  aggacgtgg  cttccctga  ttcaggtgt  aggaaggcc  2400
ggaggaggg  ggctgcctg  cccgcccac  gtgcccaca  gagtgcgcc  gcctggaca  2460
cgtggtccg  tgcagcaac  agcacctgc  ggccctgcc  aagggcatt  ccaagaatg  2520
cacagaact  tatttggac  ggaaccagt  cacgctggt  ccgggacag  tgtctacct  2580
caagtacct  cagctcgtg  acctgagca  caacaagat  agttcctta  gcaattcct  2640
cttcaccaa  atgagccag  tgaccactc  gatcctcag  tacaatgcc  tgcagtgca  2700
cccgccttt  gccttccag  gactccgct  cctgcgcct  ctgtctctc  acggcaatg  2760
catctccac  ctccaagag  gcatctttg  agacgtgac  tccctgtct  acctggcca  2820
tggtgccaa  cccctatac  gtgactgcc  cctccgctg  ctgtccagc  gggtgaaga  2880
tggctacaa  gaaccgggc  ttgctcgtt  tgctgggcc  caggacatg  agggcaagc  2940
gctcctcac  acgcctgcc  agaagtttg  atgccaagg  cctccaacg  tggctgtcc  3000
ggccaagtg  gatctctgc  tgtccagtc  gtgccagaa  cagggcacc  gccacaacg  3060
cccccttga  gtgtacagg  gcgcctgcc  cagcggcta  aagggtcga  actgtgagg  3120
gtccctgaa  agctgttcc  gtggcccct  tgaaaatgg  ggcacctgc  atgcacagg  3180
gggcgagga  gccccgttc  cgtgctcct  tcccaccgg  tttgaagga  caacctgtg  3240
ggtgaacac  gatgactgt  tggatcatg  ctgtgccaa  gggggcgtc  gtgtggatg  3300
tgtgggcaa  tacacctgc  agtgccccc  gcagtatga  ggaaaggcc  gtgagcagc  3360
ggtggactt  tgctctccg  atctgaacc  atgtcaaca  gaggcccag  gtgtgggca  3420
cccggatgg  cccaggtgt  agtgcatgc  aggttatgc  ggtgacaac  gcagtgaga  3480
ccaggatga  tgcagggac  accgctgcc  gaatggggc  cagtgtatg  atgaagtca  3540
cagctactc  tgcctctgt  ctgagggct  cagtggaca  ctctgtgag  tccctcccc  3600
tctgcctgc  cccaagagc  cctgtgagg  gactgagtg  cagaatggg  ccaactgtg  3660
ggaccaggg  aacaggcct  tgtgccagt  cctcccagg  ttcggtggc  ctgagtgtg  3720
gaagttgct  agtgtcaac  ttgtggatc  ggacactta  ctgcagttc  ctgacctgc  3780
aaactggcc  cgggccaac  tcacgttgc  ggtctccac  gcagaggac  atgggatcc  3840
tctgtacaa  ggggacaac  accacattg  agttgagct  taccagggc  atgtgcgtg  3900
cagctacga  ccaggcagc  accccagct  tgccatcta  agtgctgag  cgatcaacg  3960
tgggcaatt  cacaccgtt  agctggttg  ctttgacca  atggtgaat  tctccattg  4020
tggcgggag  cccatgacc  tggacaact  tggcaaaca  tacacgctc  acagcgagg  4080
gccactcta  gtgggaggg  tgcccgtgg  tgtcaactc  gctgccttc  gcctgtggc  4140
gatcctcaa  ggcaccggc  tccacggtt  catccgaaa  ctgtacatc  acaacgagc  4200
gcaggactt  accaagacg  agatgaagc  aggcgtggt  ccaggctgc  aaccctgcc  4260
caagctcta  tgcctgcat  gcatctgcc  gcccaatgc  accccaggg  ccatgtgcc  4320
ctgcgaggc  ggctgggtg  gcctgcact  tgaccagcc  gctgacggc  cctgccatg  4380
ccacaagtg  gtccatggg  aatgcgtgc  cctcgacgc  ctttcctac  gctgccagt  4440
ccaggatgg  tactcgggg  cactgtgca  ccaggccgg  gccctggca  agccctgca  4500
aggcctgca  tgcctgcat  gccactgcc  ggcctcagg  accaagggg  cacactgtg  4560
gtgtgaccc  ggcttttcg  gcgagctgt  tgagcaaga  tccgagtgc  ggggggacc  4620
tgtccggga  tttcaccag  tccagaggg  ctatgccat  tgccagacc  cgcgccccc  4680
gtcatgggt  gagtgccgg  gctcgtgcc  aggccaggg  tgctgccag  gccttcggc  4740
gaagcggag  aagttcacc  ttgagtgca  cgatgggac  tcttttgcc  aggaggtgg  4800
aaagcccac  aagtgtggc  gtgccctct  cgcatagcg  tgggcgtgg  caggccggt  4860
agggcgggc  aggggcccc  gccgctgca  cagcggaga  agtcgccag  agctgggct  4920
gggtgcagg  catcacagg  cggctcctg  gcagctggg  cctcctggg  ggggtggtg  4980
cagagcagc  ttttaaaag  aaattgcgc  atagctggg  gcagcgggg  tgggcgagg  5040
ctgagctgc  ggctgccct  tccggaagt  cttgcacaa  taggcgctt  ataa  5094



<210> 276
<211> 1534
<212> PRT
<213> Homo sapiens
<308> BAA35184
<400> 276

Met Ala Leu Thr Pro Gly Trp Gly Ser Ser Ala Gly Pro Val Arg Pro 
  1               5                  10                  15
Glu Leu Trp Leu Leu Leu Trp Ala Ala Ala Trp Arg Leu Gly Ala Ser 
             20                  25                  30
Ala Cys Pro Ala Leu Cys Thr Cys Thr Gly Thr Thr Val Asp Cys His 
         35                  40                  45
Gly Thr Gly Leu Gln Ala Ile Pro Lys Asn Ile Pro Arg Asn Thr Glu 
     50                  55                  60
Arg Leu Glu Leu Asn Gly Asn Asn Ile Thr Arg Ile His Lys Asn Asp 
 65                  70                  75                  80
Phe Ala Gly Leu Lys Gln Leu Arg Val Leu Gln Leu Met Glu Asn Gln 
                 85                  90                  95
Ile Gly Ala Val Glu Arg Gly Ala Phe Asp Asp Met Lys Glu Leu Glu 
             100                105                110
Arg Leu Arg Leu Asn Arg Asn Gln Leu His Met Leu Pro Glu Leu Leu 
         115                120                125
Phe Gln Asn Asn Gln Ala Leu Ser Arg Leu Asp Leu Ser Glu Asn Ala 
     130                135                140
Ile Gln Ala Ile Pro Arg Lys Ala Phe Arg Gly Ala Thr Asp Leu Lys 
 145                150                155                160
Asn Leu Arg Leu Asp Lys Asn Gln Ile Ser Cys Ile Glu Glu Gly Ala 
                 165                170                175
Phe Arg Ala Leu Arg Gly Leu Glu Val Leu Thr Leu Asn Asn Asn Asn 
             180                185                190
Ile Thr Thr Ile Pro Val Ser Ser Phe Asn His Met Pro Lys Leu Arg 
         195                200                205
Thr Phe Arg Leu His Ser Asn His Leu Phe Cys Asp Cys His Leu Ala 
     210                215                220
Trp Leu Ser Gln Trp Leu Arg Gln Arg Pro Thr Ile Gly Leu Phe Thr 
 225                230                235                240
Gln Cys Ser Gly Pro Ala Ser Leu Arg Gly Leu Asn Val Ala Glu Val 
                 245                250                255
Gln Lys Ser Glu Phe Ser Cys Ser Gly Gln Gly Glu Ala Gly Arg Val 
             260                265                270
Pro Thr Cys Thr Leu Ser Ser Gly Ser Cys Pro Ala Met Cys Thr Cys 
         275                280                285
Ser Asn Gly Ile Val Asp Cys Arg Gly Lys Gly Leu Thr Ala Ile Pro 
     290                295                300
Ala Asn Leu Pro Glu Thr Met Thr Glu Ile Arg Leu Glu Leu Asn Gly 
 305                310                315                320
Ile Lys Ser Ile Pro Pro Gly Ala Phe Ser Pro Tyr Arg Lys Leu Arg 
                 325                330                335
Arg Ile Asp Leu Ser Asn Asn Gln Ile Ala Glu Ile Ala Pro Asp Ala 
             340                345                350
Phe Gln Gly Leu Arg Ser Leu Asn Ser Leu Val Leu Tyr Gly Asn Lys 
         355                360                365
Ile Thr Asp Leu Pro Arg Gly Val Phe Gly Gly Leu Tyr Thr Leu Gln 
     370                375                380
Leu Leu Leu Leu Asn Ala Asn Lys Ile Asn Cys Ile Arg Pro Asp Ala 
 385                390                395                400
Phe Gln Asp Leu Gln Asn Leu Ser Leu Leu Ser Leu Tyr Asp Asn Lys 
                 405                410                415
Ile Gln Ser Leu Ala Lys Gly Thr Phe Thr Ser Leu Arg Ala Ile Gln 
             420                425                430
Thr Leu His Leu Ala Gln Asn Pro Phe Ile Cys Asp Cys Asn Leu Lys 
         435                440                445
Trp Leu Ala Asp Phe Leu Arg Thr Asn Pro Ile Glu Thr Ser Gly Ala 
     450                455                460
Arg Cys Ala Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile 
 465                470                475                480
Lys Ser Lys Lys Phe Arg Cys Ser Ala Lys Glu Gln Tyr Phe Ile Pro 
                 485                490                495
Gly Thr Glu Asp Tyr Gln Leu Asn Ser Glu Cys Asn Ser Asp Val Val 
             500                505                510
Cys Pro His Lys Cys Arg Cys Glu Ala Asn Val Val Glu Cys Ser Ser 
         515                520                525
Leu Lys Leu Thr Lys Ile Pro Glu Arg Ile Pro Gln Ser Thr Ala Glu 
     530                535                540
Leu Arg Leu Asn Asn Asn Glu Ile Ser Ile Leu Glu Ala Thr Gly Met 
 545                550                555                560
Phe Lys Lys Leu Thr His Leu Lys Lys Ile Asn Leu Ser Asn Asn Lys 
                 565                570                575
Val Ser Glu Ile Glu Asp Gly Ala Phe Glu Gly Ala Ala Ser Val Ser 
             580                585                590
Glu Leu His Leu Thr Ala Asn Gln Leu Glu Ser Ile Arg Ser Gly Met 
         595                600                605
Phe Arg Gly Leu Asp Gly Leu Arg Thr Leu Met Leu Arg Asn Asn Arg 
     610                615                620
Ile Ser Cys Ile His Asn Asp Ser Phe Thr Gly Leu Arg Asn Val Arg 
 625                630                635                640
Leu Leu Ser Leu Tyr Asp Asn Gln Ile Thr Thr Val Ser Pro Gly Ala 
                 645                650                655
Phe Asp Thr Leu Gln Ser Leu Ser Thr Leu Asn Leu Leu Ala Asn Pro 
             660                665                670
Phe Asn Cys Asn Cys Gln Leu Ala Trp Leu Gly Gly Trp Leu Arg Lys 
         675                680                685
Arg Lys Ile Val Thr Gly Asn Pro Arg Cys Gln Asn Pro Asp Phe Leu 
     690                695                700
Arg Gln Ile Pro Leu Gln Asp Val Ala Phe Pro Asp Phe Arg Cys Glu 
 705                710                715                720
Glu Gly Gln Glu Glu Gly Gly Cys Leu Pro Arg Pro Gln Cys Pro Gln 
                 725                730                735
Glu Cys Ala Cys Leu Asp Thr Val Val Arg Cys Ser Asn Lys His Leu 
             740                745                750
Arg Ala Leu Pro Lys Gly Ile Pro Lys Asn Val Thr Glu Leu Tyr Leu 
         755                760                765
Asp Gly Asn Gln Phe Thr Leu Val Pro Gly Gln Leu Ser Thr Phe Lys 
     770                775                780
Tyr Leu Gln Leu Val Asp Leu Ser Asn Asn Lys Ile Ser Ser Leu Ser 
 785                790                795                800
Asn Ser Ser Phe Thr Asn Met Ser Gln Leu Thr Thr Leu Ile Leu Ser 
                 805                810                815
Tyr Asn Ala Leu Gln Cys Ile Pro Pro Leu Ala Phe Gln Gly Leu Arg 
             820                825                830
Ser Leu Arg Leu Leu Ser Leu His Gly Asn Asp Ile Ser Thr Leu Gln 
         835                840                845
Glu Gly Ile Phe Ala Asp Val Thr Ser Leu Ser His Leu Ala Ile Gly 
     850                855                860
Ala Asn Pro Leu Tyr Cys Asp Cys His Leu Arg Trp Leu Ser Ser Trp 
 865                870                875                880
Val Lys Thr Gly Tyr Lys Glu Pro Gly Ile Ala Arg Cys Ala Gly Pro 
                 885                890                895
Gln Asp Met Glu Gly Lys Leu Leu Leu Thr Thr Pro Ala Lys Lys Phe 
             900                905                910
Glu Cys Gln Gly Pro Pro Thr Leu Ala Val Gln Ala Lys Cys Asp Leu 
         915                920                925
Cys Leu Ser Ser Pro Cys Gln Asn Gln Gly Thr Cys His Asn Asp Pro 
     930                935                940
Leu Glu Val Tyr Arg Cys Ala Cys Pro Ser Gly Tyr Lys Gly Arg Asp 
 945                950                955                960
Cys Glu Val Ser Leu Asn Ser Cys Ser Ser Gly Pro Cys Glu Asn Gly 
                 965                970                975
Gly Thr Cys His Ala Gln Glu Gly Glu Asp Ala Pro Phe Thr Cys Ser 
             980                985                990
Cys Pro Thr Gly Phe Glu Gly Pro Thr Cys Gly Val Asn Thr Asp Asp 
         995                1000                1005
Cys Val Asp His Ala Cys Ala Asn Gly Gly Val Cys Val Asp Gly Val 
     1010                1015                1020
Gly Asn Tyr Thr Cys Gln Cys Pro Leu Gln Tyr Glu Gly Lys Ala Cys 
 1025                1030                1035                1040
Glu Gln Leu Val Asp Leu Cys Ser Pro Asp Leu Asn Pro Cys Gln His 
                 1045                1050                1055
Glu Ala Gln Cys Val Gly Thr Pro Asp Gly Pro Arg Cys Glu Cys Met 
             1060                1065                1070
Pro Gly Tyr Ala Gly Asp Asn Cys Ser Glu Asn Gln Asp Asp Cys Arg 
         1075                1080                1085
Asp His Arg Cys Gln Asn Gly Ala Gln Cys Met Asp Glu Val Asn Ser 
     1090                1095                1100
Tyr Ser Cys Leu Cys Ala Glu Gly Tyr Ser Gly Gln Leu Cys Glu Ile 
 1105                1110                1115                1120
Pro Pro His Leu Pro Ala Pro Lys Ser Pro Cys Glu Gly Thr Glu Cys 
                 1125                1130                1135
Gln Asn Gly Ala Asn Cys Val Asp Gln Gly Asn Arg Pro Val Cys Gln 
             1140                1145                1150
Cys Leu Pro Gly Phe Gly Gly Pro Glu Cys Glu Lys Leu Leu Ser Val 
         1155                1160                1165
Asn Phe Val Asp Arg Asp Thr Tyr Leu Gln Phe Thr Asp Leu Gln Asn 
     1170                1175                1180
Trp Pro Arg Ala Asn Ile Thr Leu Gln Val Ser Thr Ala Glu Asp Asn 
 1185                1190                1195                1200
Gly Ile Leu Leu Tyr Asn Gly Asp Asn Asp His Ile Ala Val Glu Leu 
                 1205                1210                1215
Tyr Gln Gly His Val Arg Val Ser Tyr Asp Pro Gly Ser Tyr Pro Ser 
             1220                1225                1230
Ser Ala Ile Tyr Ser Ala Glu Thr Ile Asn Asp Gly Gln Phe His Thr 
         1235                1240                1245
Val Glu Leu Val Ala Phe Asp Gln Met Val Asn Leu Ser Ile Asp Gly 
     1250                1255                1260
Gly Ser Pro Met Thr Met Asp Asn Phe Gly Lys His Tyr Thr Leu Asn 
 1265                1270                1275                1280
Ser Glu Ala Pro Leu Tyr Val Gly Gly Met Pro Val Asp Val Asn Ser 
                 1285                1290                1295
Ala Ala Phe Arg Leu Trp Gln Ile Leu Asn Gly Thr Gly Phe His Gly 
             1300                1305                1310
Cys Ile Arg Asn Leu Tyr Ile Asn Asn Glu Leu Gln Asp Phe Thr Lys 
         1315                1320                1325
Thr Gln Met Lys Pro Gly Val Val Pro Gly Cys Glu Pro Cys Arg Lys 
     1330                1335                1340
Leu Tyr Cys Leu His Gly Ile Cys Gln Pro Asn Ala Thr Pro Gly Pro 
 1345                1350                1355                1360
Met Cys His Cys Glu Ala Gly Trp Val Gly Leu His Cys Asp Gln Pro 
                 1365                1370                1375
Ala Asp Gly Pro Cys His Gly His Lys Cys Val His Gly Gln Cys Val 
             1380                1385                1390
Pro Leu Asp Ala Leu Ser Tyr Ser Cys Gln Cys Gln Asp Gly Tyr Ser 
         1395                1400                1405
Gly Ala Leu Cys Asn Gln Ala Gly Ala Leu Ala Glu Pro Cys Arg Gly 
     1410                1415                1420
Leu Gln Cys Leu His Gly His Cys Gln Ala Ser Gly Thr Lys Gly Ala 
 1425                1430                1435                1440
His Cys Val Cys Asp Pro Gly Phe Ser Gly Glu Leu Cys Glu Gln Glu 
                 1445                1450                1455
Ser Glu Cys Arg Gly Asp Pro Val Arg Asp Phe His Gln Val Gln Arg 
             1460                1465                1470
Gly Tyr Ala Ile Cys Gln Thr Thr Arg Pro Leu Ser Trp Val Glu Cys 
         1475                1480                1485
Arg Gly Ser Cys Pro Gly Gln Gly Cys Cys Gln Gly Leu Arg Leu Lys 
     1490                1495                1500
Arg Arg Lys Phe Thr Phe Glu Cys Ser Asp Gly Thr Ser Phe Ala Glu 
 1505                1510                1515                1520
Glu Val Glu Lys Pro Thr Lys Cys Gly Cys Ala Leu Cys Ala 
                 1525                1530



<210> 277
<211> 1903
<212> DNA
<213> Rattus norvegicus
<308> AB017544
<400> 277

gtcaggcct  aggaagatg  cgtcctcgg  gcaggcaga  cagccgaac  agcccagct  60
ttctccagg  agtgaaaat  tggtgcctc  agagcctct  attgccaca  cagtgaagt  120
cctacagaa  tctcgggtc  ggcagagcc  acttgcgac  aggagagca  ttcttaaga  180
gaaagggct  acagatgaa  agattgacc  ggctttcca  cagtcgggc  ctgcttccg  240
cgagccttc  cccgtgggc  cagctaccc  ggtggttcc  gtccagccc  ctcacctca  300
ttcacagcc  tacagcccc  gaggttccc  atggcgaga  tacggtgcc  tggccatca  360
cctggcagg  attgcattt  gcttccacc  gctctacaa  aagtacctg  tgcccctca  420
cctgggagg  cgagaggac  ggaagcagc  ggagaggat  gcggcgagt  tctcggaac  480
gagtggcag  gtggcccag  cagtgactc  ggtacagac  acactggcc  ctgtccagg  540
gctactgag  cagcagcag  agaaggtcc  ggagctagc  catgagctg  ccgctgcca  600
ggctaccac  tcaaccaac  ggatcctgg  gtcccagaa  atcaatgag  tcaagtcag  660
aatcaactc  ctgaaagga  ttcttctga  tcggagaca  ttccctccc  ccccgtcag  720
cccgaagat  ccctcctgg  agatcccag  gaagtctcc  tcaccctcc  gccccgcgg  780
cgtgaacca  cacagcagc  gtgacatct  ccctgtcag  aatgagtct  cgtcctcct  840
tccagggaa  gacggccac  gccctgagg  ctccacagc  acataccgc  tgctggggc  900
tcaggaaga  ggggaaggg  tgatggacg  caagggcca  gtgaggatg  aggtgcaag  960
ggaggagga  aagagggag  acgaggagg  cgaggagga  gaggatgat  acgtgagcc  1020
cgtggatga  gaggacgtc  tcggggtac  gagggagga  agacggggc  gcgatgggc  1080
gatcaatga  caggtagag  agctgcggc  gccagaggg  gccagcaat  agagtgagc  1140
agactaggg  tggcgcttg  ttgcccgcc  tcccagtgc  ccagggcct  agaggcggg  1200
gggcaagag  tgtggctct  cttccatga  gggggccgg  aacccaggt  ggggtgggg  1260
cgtccttcc  tgcagtgtg  gctgcgttt  ttttcacca  cctcccaga  aggttccca  1320
ccccagcca  gggcccagg  cgagaactc  ggagctctg  actccagcc  cctccttga  1380
gggtgtctt  tctaggtgt  tcctctgag  accttgacc  cctgacacc  tgcatggcc  1440
gagctcatg  catttcctg  ctctgtcac  tcagtgcag  ggaactatg  cccccctcg  1500
tcttgctgt  tcccccact  tgccctggc  tggcttgtg  cttcttctt  gcctgttcc  1560
atagccagg  tgccagccc  gctcttcat  tctggggct  ccagccttc  cacagccag  1620
tcctggctg  cagatgccg  ccttgggcg  ctgtcccca  cccacctgc  cgttgtttt  1680
tataccaca  gagacgtcc  cgcttgctg  gtcgtggtt  agctactca  tggtgaggc  1740
tgcttctcc  tcctgcggt  gaggaggca  cagggcctt  ctgaccaac  gccatgtct  1800
tccttccca  tgagaaaca  atgttcatt  acgtgatca  gtatagatt  cagactata  1860
gataagact  tacataatg  aataaatac  agttgccat  ttt  1903



<210> 278
<211> 376
<212> PRT
<213> Rattus norvegicus
<308> BAA36835
<400> 278

Met Ala Ser Ser Glu Gln Ala Glu Gln Pro Asn Gln Pro Ser Ser Ser 
  1               5                  10                  15
Pro Gly Ser Glu Asn Val Val Pro Arg Glu Pro Leu Ile Ala Thr Ala 
             20                  25                  30
Val Lys Phe Leu Gln Asn Ser Arg Val Arg Gln Ser Pro Leu Ala Thr 
         35                  40                  45
Arg Arg Ala Phe Leu Lys Lys Lys Gly Leu Thr Asp Glu Glu Ile Asp 
     50                  55                  60
Leu Ala Phe Gln Gln Ser Gly Thr Ala Ser Asp Glu Pro Ser Pro Val 
 65                  70                  75                  80
Gly Pro Ala Thr Pro Val Val Pro Val Gln Pro Pro His Leu Ile Ser 
                 85                  90                  95
Gln Pro Tyr Ser Pro Gly Gly Ser Arg Trp Arg Asp Tyr Gly Ala Leu 
             100                105                110
Ala Ile Ile Leu Ala Gly Ile Ala Phe Gly Phe His Gln Leu Tyr Lys 
         115                120                125
Lys Tyr Leu Leu Pro Leu Ile Leu Gly Gly Arg Glu Asp Arg Lys Gln 
     130                135                140
Leu Glu Arg Met Ala Ala Ser Leu Ser Glu Leu Ser Gly Ser Val Ala 
 145                150                155                160
Gln Thr Val Thr Gln Val Gln Thr Thr Leu Ala Ser Val Gln Glu Leu 
                 165                170                175
Leu Arg Gln Gln Gln Gln Lys Val Gln Glu Leu Ala His Glu Leu Ala 
             180                185                190
Ala Ala Lys Ala Thr Thr Ser Thr Asn Trp Ile Leu Glu Ser Gln Asn 
         195                200                205
Ile Asn Glu Leu Lys Ser Glu Ile Asn Ser Leu Lys Gly Leu Leu Leu 
     210                215                220
Asn Arg Arg Gln Phe Pro Pro Ser Pro Ser Ala Pro Lys Ile Pro Ser 
 225                230                235                240
Trp Gln Ile Pro Val Lys Ser Pro Ser Pro Ser Ser Pro Ala Ala Val 
                 245                250                255
Asn His His Ser Ser Ser Asp Ile Ser Pro Val Ser Asn Glu Ser Pro 
             260                265                270
Ser Ser Ser Pro Gly Lys Asp Gly His Ser Pro Glu Gly Ser Thr Ala 
         275                280                285
Thr Tyr Arg Leu Leu Gly Pro Gln Glu Glu Gly Glu Gly Val Met Asp 
     290                295                300
Val Lys Gly Gln Val Arg Met Glu Val Gln Gly Glu Glu Glu Lys Arg 
 305                310                315                320
Glu Asp Glu Glu Gly Glu Glu Asp Glu Asp Asp Asp Val Ser His Val 
                 325                330                335
Asp Glu Glu Asp Val Leu Gly Val Gln Arg Glu Asp Arg Arg Gly Gly 
             340                345                350
Asp Gly Gln Ile Asn Glu Gln Val Glu Lys Leu Arg Arg Pro Glu Gly 
         355                360                365
Ala Ser Asn Glu Ser Glu Arg Asp 
     370                375



<210> 279
<211> 1247
<212> DNA
<213> Homo sapiens
<308> AF045186
<400> 279

gaaagatgg  gtcctcgga  caggcagag  agccgagcc  gccaagctc  actccagga  60
gtgaaaatg  gctgcctcg  gagccgctg  ttgccacgg  agtgaagtt  ctacagaat  120
cccgggtcc  ccagagccc  cttgcaacc  ggagagcat  tctaaagaa  aaagggctg  180
cagatgaag  gattgatat  gccttccag  agtcgggca  tgctgccga  gagccttcg  240
ccttgggcc  agccacaca  gtggttcct  tccagcccc  tcacctcat  tctcagcca  300
acagtcccg  aggctcccg  tggcgagat  acggcgccc  ggccatcat  atggcaggc  360
ttgcatttg  ctttcacca  ctctacaag  aatacctgc  ccccctcat  ctgggcggc  420
gagaggaca  aaagcagct  gagaggatg  aggccggtc  ctctgagct  agtggcagc  480
tggcccaga  agtgactca  ttacagacg  ccctcgcct  cgtccagga  ctgctgatt  540
agcagcagc  gaagatcca  gagcttgcc  acgagctgg  cgctgccaa  gccaccaca  600
ccaccaact  gatcctgga  tcccagaat  tcaacgaac  caagtccga  attaactcc  660
tgaaagggc  tcttttaaa  cggaggcag  tccctccat  cccatcagc  ccgaagatc  720
cctcctggc  gatcccagt  aagtcaccg  caccctcca  ccctgcggc  gtgaaccac  780
acagcagca  cgacatctc  cctgtcagc  acgagtcca  gtcgtcctc  cctgggaag  840
agggccaca  ccccgaggg  tccacggtc  cctaccact  gctgggccc  caggaggaa  900
gcgaggggg  ggtggacgt  aagggccag  tgcggatgg  ggtgcaagg  gaggaggag  960
agagggagg  caaggagga  gaggaggat  aggaggatg  tgatgtgag  catgtggac  1020
aggaggact  cctgggggt  cagagggag  accgccggg  cggggatgg  cagatcaac  1080
agcaggtgg  gaagctgcg  cggcccgag  gcgccagca  cgagagtga  cgggactag  1140
gctgcgcct  ctgcctcca  ccctgagga  ggcatctag  gtgcccgtg  gtggccata  1200
cctgcctcc  tctctggcc  tgggagggc  gcttggagc  caggtag  1247



<210> 280
<211> 377
<212> PRT
<213> Homo sapiens
<308> O75381
<400> 280

Met Ala Ser Ser Glu Gln Ala Glu Gln Pro Ser Gln Pro Ser Ser Thr 
  1               5                  10                  15
Pro Gly Ser Glu Asn Val Leu Pro Arg Glu Pro Leu Ile Ala Thr Ala 
             20                  25                  30
Val Lys Phe Leu Gln Asn Ser Arg Val Arg Gln Ser Pro Leu Ala Thr 
         35                  40                  45
Arg Arg Ala Phe Leu Lys Lys Lys Gly Leu Thr Asp Glu Glu Ile Asp 
     50                  55                  60
Met Ala Phe Gln Gln Ser Gly Thr Ala Ala Asp Glu Pro Ser Ser Leu 
 65                  70                  75                  80
Gly Pro Ala Thr Gln Val Val Pro Val Gln Pro Pro His Leu Ile Ser 
                 85                  90                  95
Gln Pro Tyr Ser Pro Ala Gly Ser Arg Trp Arg Asp Tyr Gly Ala Leu 
             100                105                110
Ala Ile Ile Met Ala Gly Ile Ala Phe Gly Phe His Gln Leu Tyr Lys 
         115                120                125
Lys Tyr Leu Leu Pro Leu Ile Leu Gly Gly Arg Glu Asp Arg Lys Gln 
     130                135                140
Leu Glu Arg Met Glu Ala Gly Leu Ser Glu Leu Ser Gly Ser Val Ala 
 145                150                155                160
Gln Thr Val Thr Gln Leu Gln Thr Thr Leu Ala Ser Val Gln Glu Leu 
                 165                170                175
Leu Ile Gln Gln Gln Gln Lys Ile Gln Glu Leu Ala His Glu Leu Ala 
             180                185                190
Ala Ala Lys Ala Thr Thr Ser Thr Asn Trp Ile Leu Glu Ser Gln Asn 
         195                200                205
Ile Asn Glu Leu Lys Ser Glu Ile Asn Ser Leu Lys Gly Leu Leu Leu 
     210                215                220
Asn Arg Arg Gln Phe Pro Pro Ser Pro Ser Ala Pro Lys Ile Pro Ser 
 225                230                235                240
Trp Gln Ile Pro Val Lys Ser Pro Ser Pro Ser Ser Pro Ala Ala Val 
                 245                250                255
Asn His His Ser Ser Ser Asp Ile Ser Pro Val Ser Asn Glu Ser Thr 
             260                265                270
Ser Ser Ser Pro Gly Lys Glu Gly His Ser Pro Glu Gly Ser Thr Val 
         275                280                285
Thr Tyr His Leu Leu Gly Pro Gln Glu Glu Gly Glu Gly Val Val Asp 
     290                295                300
Val Lys Gly Gln Val Arg Met Glu Val Gln Gly Glu Glu Glu Lys Arg 
 305                310                315                320
Glu Asp Lys Glu Asp Glu Glu Asp Glu Glu Asp Asp Asp Val Ser His 
                 325                330                335
Val Asp Glu Glu Asp Cys Leu Gly Val Gln Arg Glu Asp Arg Arg Gly 
             340                345                350
Gly Asp Gly Gln Ile Asn Glu Gln Val Glu Lys Leu Arg Arg Pro Glu 
         355                360                365
Gly Ala Ser Asn Glu Ser Glu Arg Asp 
     370                375



<210> 281
<211> 1903
<212> DNA
<213> Rattus norvegicus
<308> AB017544
<400> 281

gtcaggcct  aggaagatg  cgtcctcgg  gcaggcaga  cagccgaac  agcccagct  60
ttctccagg  agtgaaaat  tggtgcctc  agagcctct  attgccaca  cagtgaagt  120
cctacagaa  tctcgggtc  ggcagagcc  acttgcgac  aggagagca  ttcttaaga  180
gaaagggct  acagatgaa  agattgacc  ggctttcca  cagtcgggc  ctgcttccg  240
cgagccttc  cccgtgggc  cagctaccc  ggtggttcc  gtccagccc  ctcacctca  300
ttcacagcc  tacagcccc  gaggttccc  atggcgaga  tacggtgcc  tggccatca  360
cctggcagg  attgcattt  gcttccacc  gctctacaa  aagtacctg  tgcccctca  420
cctgggagg  cgagaggac  ggaagcagc  ggagaggat  gcggcgagt  tctcggaac  480
gagtggcag  gtggcccag  cagtgactc  ggtacagac  acactggcc  ctgtccagg  540
gctactgag  cagcagcag  agaaggtcc  ggagctagc  catgagctg  ccgctgcca  600
ggctaccac  tcaaccaac  ggatcctgg  gtcccagaa  atcaatgag  tcaagtcag  660
aatcaactc  ctgaaagga  ttcttctga  tcggagaca  ttccctccc  ccccgtcag  720
cccgaagat  ccctcctgg  agatcccag  gaagtctcc  tcaccctcc  gccccgcgg  780
cgtgaacca  cacagcagc  gtgacatct  ccctgtcag  aatgagtct  cgtcctcct  840
tccagggaa  gacggccac  gccctgagg  ctccacagc  acataccgc  tgctggggc  900
tcaggaaga  ggggaaggg  tgatggacg  caagggcca  gtgaggatg  aggtgcaag  960
ggaggagga  aagagggag  acgaggagg  cgaggagga  gaggatgat  acgtgagcc  1020
cgtggatga  gaggacgtc  tcggggtac  gagggagga  agacggggc  gcgatgggc  1080
gatcaatga  caggtagag  agctgcggc  gccagaggg  gccagcaat  agagtgagc  1140
agactaggg  tggcgcttg  ttgcccgcc  tcccagtgc  ccagggcct  agaggcggg  1200
gggcaagag  tgtggctct  cttccatga  gggggccgg  aacccaggt  ggggtgggg  1260
cgtccttcc  tgcagtgtg  gctgcgttt  ttttcacca  cctcccaga  aggttccca  1320
ccccagcca  gggcccagg  cgagaactc  ggagctctg  actccagcc  cctccttga  1380
gggtgtctt  tctaggtgt  tcctctgag  accttgacc  cctgacacc  tgcatggcc  1440
gagctcatg  catttcctg  ctctgtcac  tcagtgcag  ggaactatg  cccccctcg  1500
tcttgctgt  tcccccact  tgccctggc  tggcttgtg  cttcttctt  gcctgttcc  1560
atagccagg  tgccagccc  gctcttcat  tctggggct  ccagccttc  cacagccag  1620
tcctggctg  cagatgccg  ccttgggcg  ctgtcccca  cccacctgc  cgttgtttt  1680
tataccaca  gagacgtcc  cgcttgctg  gtcgtggtt  agctactca  tggtgaggc  1740
tgcttctcc  tcctgcggt  gaggaggca  cagggcctt  ctgaccaac  gccatgtct  1800
tccttccca  tgagaaaca  atgttcatt  acgtgatca  gtatagatt  cagactata  1860
gataagact  tacataatg  aataaatac  agttgccat  ttt  1903



<210> 282
<211> 376
<212> PRT
<213> Rattus norvegicus
<308> BAA36835
<400> 282

Met Ala Ser Ser Glu Gln Ala Glu Gln Pro Asn Gln Pro Ser Ser Ser 
  1               5                  10                  15
Pro Gly Ser Glu Asn Val Val Pro Arg Glu Pro Leu Ile Ala Thr Ala 
             20                  25                  30
Val Lys Phe Leu Gln Asn Ser Arg Val Arg Gln Ser Pro Leu Ala Thr 
         35                  40                  45
Arg Arg Ala Phe Leu Lys Lys Lys Gly Leu Thr Asp Glu Glu Ile Asp 
     50                  55                  60
Leu Ala Phe Gln Gln Ser Gly Thr Ala Ser Asp Glu Pro Ser Pro Val 
 65                  70                  75                  80
Gly Pro Ala Thr Pro Val Val Pro Val Gln Pro Pro His Leu Ile Ser 
                 85                  90                  95
Gln Pro Tyr Ser Pro Gly Gly Ser Arg Trp Arg Asp Tyr Gly Ala Leu 
             100                105                110
Ala Ile Ile Leu Ala Gly Ile Ala Phe Gly Phe His Gln Leu Tyr Lys 
         115                120                125
Lys Tyr Leu Leu Pro Leu Ile Leu Gly Gly Arg Glu Asp Arg Lys Gln 
     130                135                140
Leu Glu Arg Met Ala Ala Ser Leu Ser Glu Leu Ser Gly Ser Val Ala 
 145                150                155                160
Gln Thr Val Thr Gln Val Gln Thr Thr Leu Ala Ser Val Gln Glu Leu 
                 165                170                175
Leu Arg Gln Gln Gln Gln Lys Val Gln Glu Leu Ala His Glu Leu Ala 
             180                185                190
Ala Ala Lys Ala Thr Thr Ser Thr Asn Trp Ile Leu Glu Ser Gln Asn 
         195                200                205
Ile Asn Glu Leu Lys Ser Glu Ile Asn Ser Leu Lys Gly Leu Leu Leu 
     210                215                220
Asn Arg Arg Gln Phe Pro Pro Ser Pro Ser Ala Pro Lys Ile Pro Ser 
 225                230                235                240
Trp Gln Ile Pro Val Lys Ser Pro Ser Pro Ser Ser Pro Ala Ala Val 
                 245                250                255
Asn His His Ser Ser Ser Asp Ile Ser Pro Val Ser Asn Glu Ser Pro 
             260                265                270
Ser Ser Ser Pro Gly Lys Asp Gly His Ser Pro Glu Gly Ser Thr Ala 
         275                280                285
Thr Tyr Arg Leu Leu Gly Pro Gln Glu Glu Gly Glu Gly Val Met Asp 
     290                295                300
Val Lys Gly Gln Val Arg Met Glu Val Gln Gly Glu Glu Glu Lys Arg 
 305                310                315                320
Glu Asp Glu Glu Gly Glu Glu Asp Glu Asp Asp Asp Val Ser His Val 
                 325                330                335
Asp Glu Glu Asp Val Leu Gly Val Gln Arg Glu Asp Arg Arg Gly Gly 
             340                345                350
Asp Gly Gln Ile Asn Glu Gln Val Glu Lys Leu Arg Arg Pro Glu Gly 
         355                360                365
Ala Ser Asn Glu Ser Glu Arg Asp 
     370                375



<210> 283
<211> 1247
<212> DNA
<213> Homo sapiens
<308> AF045186
<400> 283

gaaagatgg  gtcctcgga  caggcagag  agccgagcc  gccaagctc  actccagga  60
gtgaaaatg  gctgcctcg  gagccgctg  ttgccacgg  agtgaagtt  ctacagaat  120
cccgggtcc  ccagagccc  cttgcaacc  ggagagcat  tctaaagaa  aaagggctg  180
cagatgaag  gattgatat  gccttccag  agtcgggca  tgctgccga  gagccttcg  240
ccttgggcc  agccacaca  gtggttcct  tccagcccc  tcacctcat  tctcagcca  300
acagtcccg  aggctcccg  tggcgagat  acggcgccc  ggccatcat  atggcaggc  360
ttgcatttg  ctttcacca  ctctacaag  aatacctgc  ccccctcat  ctgggcggc  420
gagaggaca  aaagcagct  gagaggatg  aggccggtc  ctctgagct  agtggcagc  480
tggcccaga  agtgactca  ttacagacg  ccctcgcct  cgtccagga  ctgctgatt  540
agcagcagc  gaagatcca  gagcttgcc  acgagctgg  cgctgccaa  gccaccaca  600
ccaccaact  gatcctgga  tcccagaat  tcaacgaac  caagtccga  attaactcc  660
tgaaagggc  tcttttaaa  cggaggcag  tccctccat  cccatcagc  ccgaagatc  720
cctcctggc  gatcccagt  aagtcaccg  caccctcca  ccctgcggc  gtgaaccac  780
acagcagca  cgacatctc  cctgtcagc  acgagtcca  gtcgtcctc  cctgggaag  840
agggccaca  ccccgaggg  tccacggtc  cctaccact  gctgggccc  caggaggaa  900
gcgaggggg  ggtggacgt  aagggccag  tgcggatgg  ggtgcaagg  gaggaggag  960
agagggagg  caaggagga  gaggaggat  aggaggatg  tgatgtgag  catgtggac  1020
aggaggact  cctgggggt  cagagggag  accgccggg  cggggatgg  cagatcaac  1080
agcaggtgg  gaagctgcg  cggcccgag  gcgccagca  cgagagtga  cgggactag  1140
gctgcgcct  ctgcctcca  ccctgagga  ggcatctag  gtgcccgtg  gtggccata  1200
cctgcctcc  tctctggcc  tgggagggc  gcttggagc  caggtag  1247



<210> 284
<211> 377
<212> PRT
<213> Homo sapiens
<308> O75381
<400> 284

Met Ala Ser Ser Glu Gln Ala Glu Gln Pro Ser Gln Pro Ser Ser Thr 
  1               5                  10                  15
Pro Gly Ser Glu Asn Val Leu Pro Arg Glu Pro Leu Ile Ala Thr Ala 
             20                  25                  30
Val Lys Phe Leu Gln Asn Ser Arg Val Arg Gln Ser Pro Leu Ala Thr 
         35                  40                  45
Arg Arg Ala Phe Leu Lys Lys Lys Gly Leu Thr Asp Glu Glu Ile Asp 
     50                  55                  60
Met Ala Phe Gln Gln Ser Gly Thr Ala Ala Asp Glu Pro Ser Ser Leu 
 65                  70                  75                  80
Gly Pro Ala Thr Gln Val Val Pro Val Gln Pro Pro His Leu Ile Ser 
                 85                  90                  95
Gln Pro Tyr Ser Pro Ala Gly Ser Arg Trp Arg Asp Tyr Gly Ala Leu 
             100                105                110
Ala Ile Ile Met Ala Gly Ile Ala Phe Gly Phe His Gln Leu Tyr Lys 
         115                120                125
Lys Tyr Leu Leu Pro Leu Ile Leu Gly Gly Arg Glu Asp Arg Lys Gln 
     130                135                140
Leu Glu Arg Met Glu Ala Gly Leu Ser Glu Leu Ser Gly Ser Val Ala 
 145                150                155                160
Gln Thr Val Thr Gln Leu Gln Thr Thr Leu Ala Ser Val Gln Glu Leu 
                 165                170                175
Leu Ile Gln Gln Gln Gln Lys Ile Gln Glu Leu Ala His Glu Leu Ala 
             180                185                190
Ala Ala Lys Ala Thr Thr Ser Thr Asn Trp Ile Leu Glu Ser Gln Asn 
         195                200                205
Ile Asn Glu Leu Lys Ser Glu Ile Asn Ser Leu Lys Gly Leu Leu Leu 
     210                215                220
Asn Arg Arg Gln Phe Pro Pro Ser Pro Ser Ala Pro Lys Ile Pro Ser 
 225                230                235                240
Trp Gln Ile Pro Val Lys Ser Pro Ser Pro Ser Ser Pro Ala Ala Val 
                 245                250                255
Asn His His Ser Ser Ser Asp Ile Ser Pro Val Ser Asn Glu Ser Thr 
             260                265                270
Ser Ser Ser Pro Gly Lys Glu Gly His Ser Pro Glu Gly Ser Thr Val 
         275                280                285
Thr Tyr His Leu Leu Gly Pro Gln Glu Glu Gly Glu Gly Val Val Asp 
     290                295                300
Val Lys Gly Gln Val Arg Met Glu Val Gln Gly Glu Glu Glu Lys Arg 
 305                310                315                320
Glu Asp Lys Glu Asp Glu Glu Asp Glu Glu Asp Asp Asp Val Ser His 
                 325                330                335
Val Asp Glu Glu Asp Cys Leu Gly Val Gln Arg Glu Asp Arg Arg Gly 
             340                345                350
Gly Asp Gly Gln Ile Asn Glu Gln Val Glu Lys Leu Arg Arg Pro Glu 
         355                360                365
Gly Ala Ser Asn Glu Ser Glu Arg Asp 
     370                375



<210> 285
<211> 1903
<212> DNA
<213> Rattus norvegicus
<308> AB017544
<400> 285

gtcaggcct  aggaagatg  cgtcctcgg  gcaggcaga  cagccgaac  agcccagct  60
ttctccagg  agtgaaaat  tggtgcctc  agagcctct  attgccaca  cagtgaagt  120
cctacagaa  tctcgggtc  ggcagagcc  acttgcgac  aggagagca  ttcttaaga  180
gaaagggct  acagatgaa  agattgacc  ggctttcca  cagtcgggc  ctgcttccg  240
cgagccttc  cccgtgggc  cagctaccc  ggtggttcc  gtccagccc  ctcacctca  300
ttcacagcc  tacagcccc  gaggttccc  atggcgaga  tacggtgcc  tggccatca  360
cctggcagg  attgcattt  gcttccacc  gctctacaa  aagtacctg  tgcccctca  420
cctgggagg  cgagaggac  ggaagcagc  ggagaggat  gcggcgagt  tctcggaac  480
gagtggcag  gtggcccag  cagtgactc  ggtacagac  acactggcc  ctgtccagg  540
gctactgag  cagcagcag  agaaggtcc  ggagctagc  catgagctg  ccgctgcca  600
ggctaccac  tcaaccaac  ggatcctgg  gtcccagaa  atcaatgag  tcaagtcag  660
aatcaactc  ctgaaagga  ttcttctga  tcggagaca  ttccctccc  ccccgtcag  720
cccgaagat  ccctcctgg  agatcccag  gaagtctcc  tcaccctcc  gccccgcgg  780
cgtgaacca  cacagcagc  gtgacatct  ccctgtcag  aatgagtct  cgtcctcct  840
tccagggaa  gacggccac  gccctgagg  ctccacagc  acataccgc  tgctggggc  900
tcaggaaga  ggggaaggg  tgatggacg  caagggcca  gtgaggatg  aggtgcaag  960
ggaggagga  aagagggag  acgaggagg  cgaggagga  gaggatgat  acgtgagcc  1020
cgtggatga  gaggacgtc  tcggggtac  gagggagga  agacggggc  gcgatgggc  1080
gatcaatga  caggtagag  agctgcggc  gccagaggg  gccagcaat  agagtgagc  1140
agactaggg  tggcgcttg  ttgcccgcc  tcccagtgc  ccagggcct  agaggcggg  1200
gggcaagag  tgtggctct  cttccatga  gggggccgg  aacccaggt  ggggtgggg  1260
cgtccttcc  tgcagtgtg  gctgcgttt  ttttcacca  cctcccaga  aggttccca  1320
ccccagcca  gggcccagg  cgagaactc  ggagctctg  actccagcc  cctccttga  1380
gggtgtctt  tctaggtgt  tcctctgag  accttgacc  cctgacacc  tgcatggcc  1440
gagctcatg  catttcctg  ctctgtcac  tcagtgcag  ggaactatg  cccccctcg  1500
tcttgctgt  tcccccact  tgccctggc  tggcttgtg  cttcttctt  gcctgttcc  1560
atagccagg  tgccagccc  gctcttcat  tctggggct  ccagccttc  cacagccag  1620
tcctggctg  cagatgccg  ccttgggcg  ctgtcccca  cccacctgc  cgttgtttt  1680
tataccaca  gagacgtcc  cgcttgctg  gtcgtggtt  agctactca  tggtgaggc  1740
tgcttctcc  tcctgcggt  gaggaggca  cagggcctt  ctgaccaac  gccatgtct  1800
tccttccca  tgagaaaca  atgttcatt  acgtgatca  gtatagatt  cagactata  1860
gataagact  tacataatg  aataaatac  agttgccat  ttt  1903



<210> 286
<211> 376
<212> PRT
<213> Rattus norvegicus
<308> BAA36835
<400> 286

Met Ala Ser Ser Glu Gln Ala Glu Gln Pro Asn Gln Pro Ser Ser Ser 
  1               5                  10                  15
Pro Gly Ser Glu Asn Val Val Pro Arg Glu Pro Leu Ile Ala Thr Ala 
             20                  25                  30
Val Lys Phe Leu Gln Asn Ser Arg Val Arg Gln Ser Pro Leu Ala Thr 
         35                  40                  45
Arg Arg Ala Phe Leu Lys Lys Lys Gly Leu Thr Asp Glu Glu Ile Asp 
     50                  55                  60
Leu Ala Phe Gln Gln Ser Gly Thr Ala Ser Asp Glu Pro Ser Pro Val 
 65                  70                  75                  80
Gly Pro Ala Thr Pro Val Val Pro Val Gln Pro Pro His Leu Ile Ser 
                 85                  90                  95
Gln Pro Tyr Ser Pro Gly Gly Ser Arg Trp Arg Asp Tyr Gly Ala Leu 
             100                105                110
Ala Ile Ile Leu Ala Gly Ile Ala Phe Gly Phe His Gln Leu Tyr Lys 
         115                120                125
Lys Tyr Leu Leu Pro Leu Ile Leu Gly Gly Arg Glu Asp Arg Lys Gln 
     130                135                140
Leu Glu Arg Met Ala Ala Ser Leu Ser Glu Leu Ser Gly Ser Val Ala 
 145                150                155                160
Gln Thr Val Thr Gln Val Gln Thr Thr Leu Ala Ser Val Gln Glu Leu 
                 165                170                175
Leu Arg Gln Gln Gln Gln Lys Val Gln Glu Leu Ala His Glu Leu Ala 
             180                185                190
Ala Ala Lys Ala Thr Thr Ser Thr Asn Trp Ile Leu Glu Ser Gln Asn 
         195                200                205
Ile Asn Glu Leu Lys Ser Glu Ile Asn Ser Leu Lys Gly Leu Leu Leu 
     210                215                220
Asn Arg Arg Gln Phe Pro Pro Ser Pro Ser Ala Pro Lys Ile Pro Ser 
 225                230                235                240
Trp Gln Ile Pro Val Lys Ser Pro Ser Pro Ser Ser Pro Ala Ala Val 
                 245                250                255
Asn His His Ser Ser Ser Asp Ile Ser Pro Val Ser Asn Glu Ser Pro 
             260                265                270
Ser Ser Ser Pro Gly Lys Asp Gly His Ser Pro Glu Gly Ser Thr Ala 
         275                280                285
Thr Tyr Arg Leu Leu Gly Pro Gln Glu Glu Gly Glu Gly Val Met Asp 
     290                295                300
Val Lys Gly Gln Val Arg Met Glu Val Gln Gly Glu Glu Glu Lys Arg 
 305                310                315                320
Glu Asp Glu Glu Gly Glu Glu Asp Glu Asp Asp Asp Val Ser His Val 
                 325                330                335
Asp Glu Glu Asp Val Leu Gly Val Gln Arg Glu Asp Arg Arg Gly Gly 
             340                345                350
Asp Gly Gln Ile Asn Glu Gln Val Glu Lys Leu Arg Arg Pro Glu Gly 
         355                360                365
Ala Ser Asn Glu Ser Glu Arg Asp 
     370                375



<210> 287
<211> 1247
<212> DNA
<213> Homo sapiens
<308> AF045186
<400> 287

gaaagatgg  gtcctcgga  caggcagag  agccgagcc  gccaagctc  actccagga  60
gtgaaaatg  gctgcctcg  gagccgctg  ttgccacgg  agtgaagtt  ctacagaat  120
cccgggtcc  ccagagccc  cttgcaacc  ggagagcat  tctaaagaa  aaagggctg  180
cagatgaag  gattgatat  gccttccag  agtcgggca  tgctgccga  gagccttcg  240
ccttgggcc  agccacaca  gtggttcct  tccagcccc  tcacctcat  tctcagcca  300
acagtcccg  aggctcccg  tggcgagat  acggcgccc  ggccatcat  atggcaggc  360
ttgcatttg  ctttcacca  ctctacaag  aatacctgc  ccccctcat  ctgggcggc  420
gagaggaca  aaagcagct  gagaggatg  aggccggtc  ctctgagct  agtggcagc  480
tggcccaga  agtgactca  ttacagacg  ccctcgcct  cgtccagga  ctgctgatt  540
agcagcagc  gaagatcca  gagcttgcc  acgagctgg  cgctgccaa  gccaccaca  600
ccaccaact  gatcctgga  tcccagaat  tcaacgaac  caagtccga  attaactcc  660
tgaaagggc  tcttttaaa  cggaggcag  tccctccat  cccatcagc  ccgaagatc  720
cctcctggc  gatcccagt  aagtcaccg  caccctcca  ccctgcggc  gtgaaccac  780
acagcagca  cgacatctc  cctgtcagc  acgagtcca  gtcgtcctc  cctgggaag  840
agggccaca  ccccgaggg  tccacggtc  cctaccact  gctgggccc  caggaggaa  900
gcgaggggg  ggtggacgt  aagggccag  tgcggatgg  ggtgcaagg  gaggaggag  960
agagggagg  caaggagga  gaggaggat  aggaggatg  tgatgtgag  catgtggac  1020
aggaggact  cctgggggt  cagagggag  accgccggg  cggggatgg  cagatcaac  1080
agcaggtgg  gaagctgcg  cggcccgag  gcgccagca  cgagagtga  cgggactag  1140
gctgcgcct  ctgcctcca  ccctgagga  ggcatctag  gtgcccgtg  gtggccata  1200
cctgcctcc  tctctggcc  tgggagggc  gcttggagc  caggtag  1247



<210> 288
<211> 377
<212> PRT
<213> Homo sapiens
<308> O75381
<400> 288

Met Ala Ser Ser Glu Gln Ala Glu Gln Pro Ser Gln Pro Ser Ser Thr 
  1               5                  10                  15
Pro Gly Ser Glu Asn Val Leu Pro Arg Glu Pro Leu Ile Ala Thr Ala 
             20                  25                  30
Val Lys Phe Leu Gln Asn Ser Arg Val Arg Gln Ser Pro Leu Ala Thr 
         35                  40                  45
Arg Arg Ala Phe Leu Lys Lys Lys Gly Leu Thr Asp Glu Glu Ile Asp 
     50                  55                  60
Met Ala Phe Gln Gln Ser Gly Thr Ala Ala Asp Glu Pro Ser Ser Leu 
 65                  70                  75                  80
Gly Pro Ala Thr Gln Val Val Pro Val Gln Pro Pro His Leu Ile Ser 
                 85                  90                  95
Gln Pro Tyr Ser Pro Ala Gly Ser Arg Trp Arg Asp Tyr Gly Ala Leu 
             100                105                110
Ala Ile Ile Met Ala Gly Ile Ala Phe Gly Phe His Gln Leu Tyr Lys 
         115                120                125
Lys Tyr Leu Leu Pro Leu Ile Leu Gly Gly Arg Glu Asp Arg Lys Gln 
     130                135                140
Leu Glu Arg Met Glu Ala Gly Leu Ser Glu Leu Ser Gly Ser Val Ala 
 145                150                155                160
Gln Thr Val Thr Gln Leu Gln Thr Thr Leu Ala Ser Val Gln Glu Leu 
                 165                170                175
Leu Ile Gln Gln Gln Gln Lys Ile Gln Glu Leu Ala His Glu Leu Ala 
             180                185                190
Ala Ala Lys Ala Thr Thr Ser Thr Asn Trp Ile Leu Glu Ser Gln Asn 
         195                200                205
Ile Asn Glu Leu Lys Ser Glu Ile Asn Ser Leu Lys Gly Leu Leu Leu 
     210                215                220
Asn Arg Arg Gln Phe Pro Pro Ser Pro Ser Ala Pro Lys Ile Pro Ser 
 225                230                235                240
Trp Gln Ile Pro Val Lys Ser Pro Ser Pro Ser Ser Pro Ala Ala Val 
                 245                250                255
Asn His His Ser Ser Ser Asp Ile Ser Pro Val Ser Asn Glu Ser Thr 
             260                265                270
Ser Ser Ser Pro Gly Lys Glu Gly His Ser Pro Glu Gly Ser Thr Val 
         275                280                285
Thr Tyr His Leu Leu Gly Pro Gln Glu Glu Gly Glu Gly Val Val Asp 
     290                295                300
Val Lys Gly Gln Val Arg Met Glu Val Gln Gly Glu Glu Glu Lys Arg 
 305                310                315                320
Glu Asp Lys Glu Asp Glu Glu Asp Glu Glu Asp Asp Asp Val Ser His 
                 325                330                335
Val Asp Glu Glu Asp Cys Leu Gly Val Gln Arg Glu Asp Arg Arg Gly 
             340                345                350
Gly Asp Gly Gln Ile Asn Glu Gln Val Glu Lys Leu Arg Arg Pro Glu 
         355                360                365
Gly Ala Ser Asn Glu Ser Glu Arg Asp 
     370                375



<210> 289
<211> 1903
<212> DNA
<213> Rattus norvegicus
<308> AB017544
<400> 289

gtcaggcct  aggaagatg  cgtcctcgg  gcaggcaga  cagccgaac  agcccagct  60
ttctccagg  agtgaaaat  tggtgcctc  agagcctct  attgccaca  cagtgaagt  120
cctacagaa  tctcgggtc  ggcagagcc  acttgcgac  aggagagca  ttcttaaga  180
gaaagggct  acagatgaa  agattgacc  ggctttcca  cagtcgggc  ctgcttccg  240
cgagccttc  cccgtgggc  cagctaccc  ggtggttcc  gtccagccc  ctcacctca  300
ttcacagcc  tacagcccc  gaggttccc  atggcgaga  tacggtgcc  tggccatca  360
cctggcagg  attgcattt  gcttccacc  gctctacaa  aagtacctg  tgcccctca  420
cctgggagg  cgagaggac  ggaagcagc  ggagaggat  gcggcgagt  tctcggaac  480
gagtggcag  gtggcccag  cagtgactc  ggtacagac  acactggcc  ctgtccagg  540
gctactgag  cagcagcag  agaaggtcc  ggagctagc  catgagctg  ccgctgcca  600
ggctaccac  tcaaccaac  ggatcctgg  gtcccagaa  atcaatgag  tcaagtcag  660
aatcaactc  ctgaaagga  ttcttctga  tcggagaca  ttccctccc  ccccgtcag  720
cccgaagat  ccctcctgg  agatcccag  gaagtctcc  tcaccctcc  gccccgcgg  780
cgtgaacca  cacagcagc  gtgacatct  ccctgtcag  aatgagtct  cgtcctcct  840
tccagggaa  gacggccac  gccctgagg  ctccacagc  acataccgc  tgctggggc  900
tcaggaaga  ggggaaggg  tgatggacg  caagggcca  gtgaggatg  aggtgcaag  960
ggaggagga  aagagggag  acgaggagg  cgaggagga  gaggatgat  acgtgagcc  1020
cgtggatga  gaggacgtc  tcggggtac  gagggagga  agacggggc  gcgatgggc  1080
gatcaatga  caggtagag  agctgcggc  gccagaggg  gccagcaat  agagtgagc  1140
agactaggg  tggcgcttg  ttgcccgcc  tcccagtgc  ccagggcct  agaggcggg  1200
gggcaagag  tgtggctct  cttccatga  gggggccgg  aacccaggt  ggggtgggg  1260
cgtccttcc  tgcagtgtg  gctgcgttt  ttttcacca  cctcccaga  aggttccca  1320
ccccagcca  gggcccagg  cgagaactc  ggagctctg  actccagcc  cctccttga  1380
gggtgtctt  tctaggtgt  tcctctgag  accttgacc  cctgacacc  tgcatggcc  1440
gagctcatg  catttcctg  ctctgtcac  tcagtgcag  ggaactatg  cccccctcg  1500
tcttgctgt  tcccccact  tgccctggc  tggcttgtg  cttcttctt  gcctgttcc  1560
atagccagg  tgccagccc  gctcttcat  tctggggct  ccagccttc  cacagccag  1620
tcctggctg  cagatgccg  ccttgggcg  ctgtcccca  cccacctgc  cgttgtttt  1680
tataccaca  gagacgtcc  cgcttgctg  gtcgtggtt  agctactca  tggtgaggc  1740
tgcttctcc  tcctgcggt  gaggaggca  cagggcctt  ctgaccaac  gccatgtct  1800
tccttccca  tgagaaaca  atgttcatt  acgtgatca  gtatagatt  cagactata  1860
gataagact  tacataatg  aataaatac  agttgccat  ttt  1903



<210> 290
<211> 376
<212> PRT
<213> Rattus norvegicus
<308> BAA36835
<400> 290

Met Ala Ser Ser Glu Gln Ala Glu Gln Pro Asn Gln Pro Ser Ser Ser 
  1               5                  10                  15
Pro Gly Ser Glu Asn Val Val Pro Arg Glu Pro Leu Ile Ala Thr Ala 
             20                  25                  30
Val Lys Phe Leu Gln Asn Ser Arg Val Arg Gln Ser Pro Leu Ala Thr 
         35                  40                  45
Arg Arg Ala Phe Leu Lys Lys Lys Gly Leu Thr Asp Glu Glu Ile Asp 
     50                  55                  60
Leu Ala Phe Gln Gln Ser Gly Thr Ala Ser Asp Glu Pro Ser Pro Val 
 65                  70                  75                  80
Gly Pro Ala Thr Pro Val Val Pro Val Gln Pro Pro His Leu Ile Ser 
                 85                  90                  95
Gln Pro Tyr Ser Pro Gly Gly Ser Arg Trp Arg Asp Tyr Gly Ala Leu 
             100                105                110
Ala Ile Ile Leu Ala Gly Ile Ala Phe Gly Phe His Gln Leu Tyr Lys 
         115                120                125
Lys Tyr Leu Leu Pro Leu Ile Leu Gly Gly Arg Glu Asp Arg Lys Gln 
     130                135                140
Leu Glu Arg Met Ala Ala Ser Leu Ser Glu Leu Ser Gly Ser Val Ala 
 145                150                155                160
Gln Thr Val Thr Gln Val Gln Thr Thr Leu Ala Ser Val Gln Glu Leu 
                 165                170                175
Leu Arg Gln Gln Gln Gln Lys Val Gln Glu Leu Ala His Glu Leu Ala 
             180                185                190
Ala Ala Lys Ala Thr Thr Ser Thr Asn Trp Ile Leu Glu Ser Gln Asn 
         195                200                205
Ile Asn Glu Leu Lys Ser Glu Ile Asn Ser Leu Lys Gly Leu Leu Leu 
     210                215                220
Asn Arg Arg Gln Phe Pro Pro Ser Pro Ser Ala Pro Lys Ile Pro Ser 
 225                230                235                240
Trp Gln Ile Pro Val Lys Ser Pro Ser Pro Ser Ser Pro Ala Ala Val 
                 245                250                255
Asn His His Ser Ser Ser Asp Ile Ser Pro Val Ser Asn Glu Ser Pro 
             260                265                270
Ser Ser Ser Pro Gly Lys Asp Gly His Ser Pro Glu Gly Ser Thr Ala 
         275                280                285
Thr Tyr Arg Leu Leu Gly Pro Gln Glu Glu Gly Glu Gly Val Met Asp 
     290                295                300
Val Lys Gly Gln Val Arg Met Glu Val Gln Gly Glu Glu Glu Lys Arg 
 305                310                315                320
Glu Asp Glu Glu Gly Glu Glu Asp Glu Asp Asp Asp Val Ser His Val 
                 325                330                335
Asp Glu Glu Asp Val Leu Gly Val Gln Arg Glu Asp Arg Arg Gly Gly 
             340                345                350
Asp Gly Gln Ile Asn Glu Gln Val Glu Lys Leu Arg Arg Pro Glu Gly 
         355                360                365
Ala Ser Asn Glu Ser Glu Arg Asp 
     370                375



<210> 291
<211> 1247
<212> DNA
<213> Homo sapiens
<308> AF045186
<400> 291

gaaagatgg  gtcctcgga  caggcagag  agccgagcc  gccaagctc  actccagga  60
gtgaaaatg  gctgcctcg  gagccgctg  ttgccacgg  agtgaagtt  ctacagaat  120
cccgggtcc  ccagagccc  cttgcaacc  ggagagcat  tctaaagaa  aaagggctg  180
cagatgaag  gattgatat  gccttccag  agtcgggca  tgctgccga  gagccttcg  240
ccttgggcc  agccacaca  gtggttcct  tccagcccc  tcacctcat  tctcagcca  300
acagtcccg  aggctcccg  tggcgagat  acggcgccc  ggccatcat  atggcaggc  360
ttgcatttg  ctttcacca  ctctacaag  aatacctgc  ccccctcat  ctgggcggc  420
gagaggaca  aaagcagct  gagaggatg  aggccggtc  ctctgagct  agtggcagc  480
tggcccaga  agtgactca  ttacagacg  ccctcgcct  cgtccagga  ctgctgatt  540
agcagcagc  gaagatcca  gagcttgcc  acgagctgg  cgctgccaa  gccaccaca  600
ccaccaact  gatcctgga  tcccagaat  tcaacgaac  caagtccga  attaactcc  660
tgaaagggc  tcttttaaa  cggaggcag  tccctccat  cccatcagc  ccgaagatc  720
cctcctggc  gatcccagt  aagtcaccg  caccctcca  ccctgcggc  gtgaaccac  780
acagcagca  cgacatctc  cctgtcagc  acgagtcca  gtcgtcctc  cctgggaag  840
agggccaca  ccccgaggg  tccacggtc  cctaccact  gctgggccc  caggaggaa  900
gcgaggggg  ggtggacgt  aagggccag  tgcggatgg  ggtgcaagg  gaggaggag  960
agagggagg  caaggagga  gaggaggat  aggaggatg  tgatgtgag  catgtggac  1020
aggaggact  cctgggggt  cagagggag  accgccggg  cggggatgg  cagatcaac  1080
agcaggtgg  gaagctgcg  cggcccgag  gcgccagca  cgagagtga  cgggactag  1140
gctgcgcct  ctgcctcca  ccctgagga  ggcatctag  gtgcccgtg  gtggccata  1200
cctgcctcc  tctctggcc  tgggagggc  gcttggagc  caggtag  1247



<210> 292
<211> 377
<212> PRT
<213> Homo sapiens
<308> O75381
<400> 292

Met Ala Ser Ser Glu Gln Ala Glu Gln Pro Ser Gln Pro Ser Ser Thr 
  1               5                  10                  15
Pro Gly Ser Glu Asn Val Leu Pro Arg Glu Pro Leu Ile Ala Thr Ala 
             20                  25                  30
Val Lys Phe Leu Gln Asn Ser Arg Val Arg Gln Ser Pro Leu Ala Thr 
         35                  40                  45
Arg Arg Ala Phe Leu Lys Lys Lys Gly Leu Thr Asp Glu Glu Ile Asp 
     50                  55                  60
Met Ala Phe Gln Gln Ser Gly Thr Ala Ala Asp Glu Pro Ser Ser Leu 
 65                  70                  75                  80
Gly Pro Ala Thr Gln Val Val Pro Val Gln Pro Pro His Leu Ile Ser 
                 85                  90                  95
Gln Pro Tyr Ser Pro Ala Gly Ser Arg Trp Arg Asp Tyr Gly Ala Leu 
             100                105                110
Ala Ile Ile Met Ala Gly Ile Ala Phe Gly Phe His Gln Leu Tyr Lys 
         115                120                125
Lys Tyr Leu Leu Pro Leu Ile Leu Gly Gly Arg Glu Asp Arg Lys Gln 
     130                135                140
Leu Glu Arg Met Glu Ala Gly Leu Ser Glu Leu Ser Gly Ser Val Ala 
 145                150                155                160
Gln Thr Val Thr Gln Leu Gln Thr Thr Leu Ala Ser Val Gln Glu Leu 
                 165                170                175
Leu Ile Gln Gln Gln Gln Lys Ile Gln Glu Leu Ala His Glu Leu Ala 
             180                185                190
Ala Ala Lys Ala Thr Thr Ser Thr Asn Trp Ile Leu Glu Ser Gln Asn 
         195                200                205
Ile Asn Glu Leu Lys Ser Glu Ile Asn Ser Leu Lys Gly Leu Leu Leu 
     210                215                220
Asn Arg Arg Gln Phe Pro Pro Ser Pro Ser Ala Pro Lys Ile Pro Ser 
 225                230                235                240
Trp Gln Ile Pro Val Lys Ser Pro Ser Pro Ser Ser Pro Ala Ala Val 
                 245                250                255
Asn His His Ser Ser Ser Asp Ile Ser Pro Val Ser Asn Glu Ser Thr 
             260                265                270
Ser Ser Ser Pro Gly Lys Glu Gly His Ser Pro Glu Gly Ser Thr Val 
         275                280                285
Thr Tyr His Leu Leu Gly Pro Gln Glu Glu Gly Glu Gly Val Val Asp 
     290                295                300
Val Lys Gly Gln Val Arg Met Glu Val Gln Gly Glu Glu Glu Lys Arg 
 305                310                315                320
Glu Asp Lys Glu Asp Glu Glu Asp Glu Glu Asp Asp Asp Val Ser His 
                 325                330                335
Val Asp Glu Glu Asp Cys Leu Gly Val Gln Arg Glu Asp Arg Arg Gly 
             340                345                350
Gly Asp Gly Gln Ile Asn Glu Gln Val Glu Lys Leu Arg Arg Pro Glu 
         355                360                365
Gly Ala Ser Asn Glu Ser Glu Arg Asp 
     370                375



<210> 293
<211> 1401
<212> DNA
<213> Rattus norvegicus
<308> AB017655
<400> 293

atgaataac  caacaaact  ctcgaacaa  ggcttggct  ttaccagtc  ttacaagac  60
tttgaagtg  tatttattg  ccttgtggc  ggatccctc  gtctggtga  catcattgg  120
aacattctg  tcatggttt  cattaaagt  aaccgccac  ttcagactg  caacaatta  180
ttcttgttc  gcctggcct  tgctgacct  atcataggt  ttttctcca  gaacttgta  240
accctctac  ctgtgattg  ctactggcc  ttgggacct  tagtatgtg  cctttggct  300
gcattggac  atgttgtca  caatgcctc  gttatgaat  tcctcatca  cagctttga  360
agatacttc  gtgtcacga  acctctgac  tacccagtt  agcggacca  aaaaatggc  420
ggcatgatg  ttgcagctg  gtgggtcct  tccttcatc  tctgggccc  agccattct  480
ttctggcag  tcatcgtag  ggtgaggac  gtggaggat  gggagtgct  tattcagtt  540
ttttccaat  cggccgtca  cttcggcac  gccattgca  ctttctatc  gcctgtcat  600
atcatgact  tgctctatt  gcatatatc  cgggcaagc  agagtagaa  aaagaagga  660
aagaaggaa  ctgtggcca  ccaagaccc  gtatctccg  gtctggtgc  aggaagaat  720
gtaaagcca  acaataaca  tatgcctgg  ggtgatggc  gcctggaac  caacaagat  780
cagaatggc  aggctccac  ggacggcgt  actgaaaac  gtgttcagg  ggaggagaa  840
gagagctcc  atgattcga  gtcagtcag  gctgtggcc  ccaatatga  agatgatga  900
ataacccag  atgaaaaca  agtttccac  tcgctgggc  actccagag  tgacaactc  960
aagcaaaca  gcatcaaaa  tgtcaccaa  gcccaaaag  gtgatgtgt  caccccaac  1020
agtaccact  tagaactag  tgggtcgtc  ggtcagaat  gggatgaaa  gcagaacat  1080
gtagcccgc  aaatcgtga  gatgaccaa  cagcctgcc  aaaagaagc  tccaccatc  1140
cgggaaaag  aagtgacca  gacaatctt  gctatcctg  tggctttca  cataacgtg  1200
gcgccatac  atgtcatgg  gctcatcaa  actttctgt  caccctgca  ccccaatac  1260
gtatggaca  ttggctact  gctctgtta  atcaatagc  ccatcaatc  ggcctgcta  1320
gcgctttgt  atgccacct  caaaaagac  tttaagcac  tcctcatgt  tcattacaa  1380
aacataggc  ctacacggt  a  1401



<210> 294
<211> 466
<212> PRT
<213> Rattus norvegicus
<308> P10980
<400> 294

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Gly Leu Ala Ile Thr Ser 
  1               5                  10                  15
Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
             20                  25                  30
Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
         35                  40                  45
Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
     50                  55                  60
Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
 65                  70                  75                  80
Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                 85                  90                  95
Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
             100                105                110
Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
         115                120                125
Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
     130                135                140
Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
 145                150                155                160
Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                 165                170                175
Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
             180                185                190
Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
         195                200                205
Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Glu Lys Lys Glu Pro 
     210                215                220
Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
 225                230                235                240
Val Lys Pro Asn Asn Asn Asn Met Pro Gly Gly Asp Gly Gly Leu Glu 
                 245                250                255
His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Gly Val Thr Glu 
             260                265                270
Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
         275                280                285
Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
     290                295                300
Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Arg Asp Asp Asn Ser 
 305                310                315                320
Lys Gln Thr Cys Ile Lys Ile Val Thr Lys Ala Gln Lys Gly Asp Val 
                 325                330                335
Cys Thr Pro Thr Ser Thr Thr Val Glu Leu Val Gly Ser Ser Gly Gln 
             340                345                350
Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
         355                360                365
Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
     370                375                380
Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
 385                390                395                400
Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                 405                410                415
Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
             420                425                430
Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
         435                440                445
Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
     450                455                460
Thr Arg 
 465



<210> 295
<211> 1401
<212> DNA
<213> Homo sapiens
<308> NM_000739
<400> 295

atgaataac  caacaaact  ctctaacaa  agcctggct  ttacaagtc  ttataagac  60
tttgaagtg  tgtttattg  cctggtggc  ggatccctc  gtttggtga  cattatcgg  120
aacatccta  tcatggttt  cattaaagt  aaccgccac  tccagaccg  caacaatta  180
tttttattc  gcttggcct  tgctgacct  atcataggt  ttttctcca  gaacttgta  240
accctctac  ctgtgattg  ttactggcc  ttgggacct  tggtgtgtg  cctttggct  300
gccctggac  atgtggtca  caatgcctc  gttatgaat  tgctcatca  cagctttga  360
aggtacttc  gtgtcacaa  acctctgac  tacccagtc  agcggacca  aaaaatggc  420
ggtatgatg  ttgcagctg  ctgggtcct  tctttcatc  tctgggctc  agccattct  480
ttctggcag  tcattgtag  ggtgagaac  gtggaggat  gggagtgct  cattcagtt  540
ttttccaat  ctgctgtca  ctttggtac  gctattgca  ccttctatt  gccagtgat  600
atcatgact  tgctatatt  gcacatatc  cgagccagc  agagcagga  aaagaagga  660
aagaaggag  ctgttgcca  ccaagaccc  gtttctcca  gtctggtac  aggaaggat  720
gtgaagcca  acaataaca  catgcccag  agtgacgat  gcctggagc  caacaaaat  780
cagaatggc  aagccccca  ggatcctgt  actgaaaac  gtgttcagg  agaggagaa  840
gagagctcc  atgactcca  ctcagtcag  gctgttgcc  ctaatatga  agatgatga  900
ataacccag  atgaaaaca  agtttccac  tccctgggc  attccaaag  tgagaactc  960
aagcaaaca  gcatcagaa  tggcaccaa  accccaaaa  gtgactcat  taccccaac  1020
aataccacc  tggaggtag  ggggtcttc  ggtcagaat  gagatgaaa  gcagaatat  1080
gtagcccgc  agattgtga  gatgactaa  cagcctgca  aaaagaagc  tcctccttc  1140
cgggaaaag  aagtcacca  gacaatctt  gctattctg  tggctttca  catcacttg  1200
gccccatac  atgtcatgg  gctcattaa  accttttgt  caccttgca  ccccaacac  1260
gtgtggaca  ttggttact  gctttgtta  atcaacagc  ctatcaacc  tgcctgcta  1320
gcactttgc  atgccacct  caagaagac  tttaaacac  ttctcatgt  tcattataa  1380
aacataggc  ctacaaggt  a  1401



<210> 296
<211> 466
<212> PRT
<213> Homo sapiens
<308> NP_000730
<400> 296

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
  1               5                  10                  15
Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
             20                  25                  30
Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
         35                  40                  45
Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
     50                  55                  60
Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
 65                  70                  75                  80
Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                 85                  90                  95
Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
             100                105                110
Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
         115                120                125
Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
     130                135                140
Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
 145                150                155                160
Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                 165                170                175
Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
             180                185                190
Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
         195                200                205
Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
     210                215                220
Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
 225                230                235                240
Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                 245                250                255
His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
             260                265                270
Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
         275                280                285
Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
     290                295                300
Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
 305                310                315                320
Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                 325                330                335
Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
             340                345                350
Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
         355                360                365
Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
     370                375                380
Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
 385                390                395                400
Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                 405                410                415
Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
             420                425                430
Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
         435                440                445
Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
     450                455                460
Thr Arg 
 465



<210> 297
<211> 470
<212> DNA
<213> Rattus norvegicus
<308> AB017711
<400> 297

tttctctgc  ctgcgaccc  gaccggcca  taaggagaa  gtatcatgt  agacaacga  60
gacaatttc  atggcgatg  ctttgatga  gtggaggag  acgaagggc  tgacgactt  120
gaaaatgct  aggaggagg  tcaggaaaa  gttgagatt  tcccatctg  tgaacgacc  180
caggccaac  agaagcgta  caccactcc  tacatgacc  agtacgagc  agcccgagt  240
ctgggcacc  gggctctcc  gattgcgat  tgtgcccca  taatggtgg  gctggaggg  300
gagacagac  ctttgctca  cgccatgaa  gaactcaag  cccggaaga  ccccatcat  360
attcgccgt  acctgccag  tggaagcta  gaggattgg  gcgtggatg  gctcatcat  420
agcgactga  cagagctgt  aggctgtgc  aggcaccat  tctatgccca  470



<210> 298
<211> 127
<212> PRT
<213> Rattus norvegicus
<308> O88828
<400> 298

Met Ser Asp Asn Glu Asp Asn Phe Asp Gly Asp Asp Phe Asp Asp Val 
  1               5                  10                  15
Glu Glu Asp Glu Gly Leu Asp Asp Leu Glu Asn Ala Glu Glu Glu Gly 
             20                  25                  30
Gln Glu Asn Val Glu Ile Leu Pro Ser Gly Glu Arg Pro Gln Ala Asn 
         35                  40                  45
Gln Lys Arg Ile Thr Thr Pro Tyr Met Thr Lys Tyr Glu Arg Ala Arg 
     50                  55                  60
Val Leu Gly Thr Arg Ala Leu Gln Ile Ala Met Cys Ala Pro Val Met 
 65                  70                  75                  80
Val Glu Leu Glu Gly Glu Thr Asp Pro Leu Leu Ile Ala Met Lys Glu 
                 85                  90                  95
Leu Lys Ala Arg Lys Ile Pro Ile Ile Ile Arg Arg Tyr Leu Pro Asp 
             100                105                110
Gly Ser Tyr Glu Asp Trp Gly Val Asp Glu Leu Ile Ile Ser Asp 
         115                120                125



<210> 299
<211> 546
<212> DNA
<213> Homo sapiens
<308> NM_021974
<400> 299

gcgcgagtc  tagtgtcgc  gtttgcggg  ctccgcggc  ggaccgggg  gcagcgggg  60
cgctgaggc  agggtgtca  gtcagacaa  gaggacaat  ttgatggcg  cgactttga  120
gatgtggag  aggatgaag  gctagatga  ttggagaat  ccgaagagg  aggccagga  180
aatgtcgag  tcctcccct  tggggagcg  ccgcaggcc  accagaagc  aatcaccac  240
ccatacatg  ccaagtacg  gcgagcccg  gtgctgggc  cccgagcgc  ccagattgc  300
atgtgtgcc  ctgtgatgg  ggagctgga  ggggagaca  atcctctgc  cattgccat  360
aaggaactc  aggcccgaa  gatccccat  atcattcgc  gttacctgc  agatgggag  420
tatgaagac  ggggggtgg  cgagctcat  atcaccgac  gagctggag  catcttcct  480
cccttgccc  atgcccaat  ttcattctc  ctttatatg  gtaaataat  aaatattca  540
ctttcc  546



<210> 300
<211> 127
<212> PRT
<213> Homo sapiens
<308> P41584
<400> 300

Met Ser Asp Asn Glu Asp Asn Phe Asp Gly Asp Asp Phe Asp Asp Val 
  1               5                  10                  15
Glu Glu Asp Glu Gly Leu Asp Asp Leu Glu Asn Ala Glu Glu Glu Gly 
             20                  25                  30
Gln Glu Asn Val Glu Ile Leu Pro Ser Gly Glu Arg Pro Gln Ala Asn 
         35                  40                  45
Gln Lys Arg Ile Thr Thr Pro Tyr Met Thr Lys Tyr Glu Arg Ala Arg 
     50                  55                  60
Val Leu Gly Thr Arg Ala Leu Gln Ile Ala Met Cys Ala Pro Val Met 
 65                  70                  75                  80
Val Glu Leu Glu Gly Glu Thr Asp Pro Leu Leu Ile Ala Met Lys Glu 
                 85                  90                  95
Leu Lys Ala Arg Lys Ile Pro Ile Ile Ile Arg Arg Tyr Leu Pro Asp 
             100                105                110
Gly Ser Tyr Glu Asp Trp Gly Val Asp Glu Leu Ile Ile Thr Asp 
         115                120                125



<210> 301
<211> 1942
<212> DNA
<213> Rattus norvegicus
<308> AB017912
<400> 301

ggagcagct  gctcgcctg  agctcgcga  cgctgagcg  gccgcccga  gggtagatt  60
accaggctg  ttctgagtg  ggattgtta  ccttggtaa  aaaatgtcg  ccatcttgc  120
attcactcc  ccagtggtg  agagacttc  gggatggaa  aaatcagcc  gtgggtctg  180
aggagcagg  ggtggagaa  agaatggac  ggaagaaaa  tggtgtgaa  aagcagtga  240
aagtctggt  aaaaagcta  agaaaacag  acgattaga  gagcttgag  aagccatca  300
cactcagaa  tgcaatact  agtgtgtca  cataccaag  acttgctct  aaatttggg  360
actgagtac  gcaaatacg  tagatcagt  ggacacaac  ggcctttac  gcttctctg  420
acaaaccag  tctcttgat  gtcgtcttc  ggtgtctca  cggaaaggg  tgccacatg  480
tatatattg  cggctgtgg  gctggccag  ccttcacag  catcatgag  tcaaggcga  540
cgagaactg  gaatacgct  tcagtctga  aaaagatga  gtgtgtgtg  acccttacc  600
ctaccagag  gtggagaca  cagtcttgc  tccagtctt  gtgcctcgg  acacagaga  660
tctaacaga  ctgccgcct  tggatgact  tacccactc  attccagaa  acacaaatt  720
cccagcagg  attgagcca  agagtaatt  catcccaga  acaccacca  ctggatata  780
cagtgaaga  ggagaaact  gtgaccaac  gttgaacca  agtatggac  caggctctc  840
ggctgaact  tctcctacc  ctctctccc  tgtcaatca  agcttggat  tgcagccag  900
tacttattc  gaacctgca  tttggtgtt  aatcgcata  tatgaacta  accagaggg  960
tggagagac  ttccatgcg  cacagccct  actcactgt  gacggcttt  cagatccat  1020
gaactcgga  aggttctgc  taggtttgc  ctccaacgt  aacagaaac  ctactgtag  1080
aatgaccag  aggcatata  gaaggggag  gcgcttgta  tacataggt  gggaagtgt  1140
tgccgagtg  ctaagtgat  gtgcgatct  tgtgcagag  cccaactgt  accagagat  1200
cggctggca  cccgcgaca  tgtgcaaaa  cccaccagg  tgtaacctg  agatcttca  1260
caaccaaga  tttgctgct  ttctggctc  gtctgttaa  cagggtttt  aggccgttt  1320
tcagctgac  cgaatgtgc  ccataagaa  gagcttcgt  aaggggtgg  gagcagaat  1380
ccggaggca  acagtaaca  gtactcctt  ctggattga  cttcatctg  atggccccc  1440
gcagtggtt  gacaaagta  taactcaga  gggatcccc  tcagtgcga  gctcaagca  1500
gtcctaaag  ccgtcagca  tggagctca  tggaagact  aacgtacca  ctcctccgc  1560
acagtactc  tgtgtgatc  cgtggactg  gctagtcaa  acccagagc  aaaacagca  1620
ttgaggtct  atcagttaa  gcaccttgt  gagtctgtt  cctacattt  aattttaga  1680
gggaaatta  tgtctagaa  tgccctccc  agaggggac  aagaagact  aaagactta  1740
tgatgtttc  ttgggcata  gacagtgtc  caaaggtta  taataccag  agtagttgt  1800
tacagtaac  tgtccagac  cagtattgc  gtgctctgc  gtttgtata  cttcttagt  1860
tgcataaat  aggtgtgtg  tgctgcttg  tctaggcaa  cctttataa  attacagta  1920
ctaatctgt  attcccaaa  aa  1942



<210> 302
<211> 467
<212> PRT
<213> Rattus norvegicus
<308> O70436
<400> 302

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
  1               5                  10                  15
Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
             20                  25                  30
Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
         35                  40                  45
Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
     50                  55                  60
Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Ser Thr 
 65                  70                  75                  80
Cys Ser Glu Ile Trp Gly Leu Ser Thr Ala Asn Thr Val Asp Gln Trp 
                 85                  90                  95
Asp Thr Thr Gly Leu Tyr Ser Phe Ser Glu Gln Thr Arg Ser Leu Asp 
             100                105                110
Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr 
         115                120                125
Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu Leu Lys 
     130                135                140
Ala Ile Glu Asn Cys Glu Tyr Ala Phe Ser Leu Lys Lys Asp Glu Val 
 145                150                155                160
Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val Leu Pro 
                 165                170                175
Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu Pro Pro 
             180                185                190
Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe Pro Ala 
         195                200                205
Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro Pro Gly 
     210                215                220
Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn Gln Ser 
 225                230                235                240
Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu Ser Pro 
                 245                250                255
Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu Pro Ala 
             260                265                270
Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu 
         275                280                285
Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp 
     290                295                300
Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn 
 305                310                315                320
Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val 
                 325                330                335
Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp 
             340                345                350
Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp 
         355                360                365
His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile 
     370                375                380
Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln 
 385                390                395                400
Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met 
                 405                410                415
Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr 
             420                425                430
Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp 
         435                440                445
Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser 
     450                455                460
Ser Met Ser 
 465



<210> 303
<211> 2041
<212> DNA
<213> Homo sapiens
<308> U68018
<400> 303

aggttcgat  caagaggct  ttttcctag  gtggcttgc  gcctttggt  agaacatgt  60
gtccatctt  ccattcacg  cgccagttg  gaagagact  ctgggatgg  agaagtcag  120
tggtgggtc  ggaggagca  gcggaggag  gcagaatgg  caggaagaa  agtggtgtg  180
gaaagcagt  aaaagtctg  tgaagaagc  aaagaaaac  ggacgatta  atgagcttg  240
gaaagccat  accactcaa  actgtaata  taaatgtgt  accatacca  gcacttgct  300
tgaaatttg  ggactgagt  caccaaata  gatagatca  tgggataca  caggccttt  360
cagcttctc  gaacaaacc  ggtctcttg  tggtcgtct  caggtatcc  atcgaaaag  420
attgccaca  gttatatat  gccgattat  gcgctggcc  gatcttcac  gtcatcatg  480
actcaaggc  attgaaaac  gcgaatatg  ttttaatct  aaaaaggat  aagtatgtg  540
aaaccctta  cactatcag  gagttgaga  accagtttt  cctccagta  tagtgcccc  600
acacaccga  atcctaaca  aacttccgc  tctggatga  tatactcac  ccattccag  660
aaacactaa  ttcccagca  gaattgagc  acagagtaa  tatattcca  aaacgccac  720
tcctggata  atcagtgaa  atggagaaa  aagtgacca  cagttgaat  aaagtatgg  780
cacaggctc  ccagcagaa  tatctccta  tactctttc  cctgttaat  atagcttgg  840
tttacagcc  gttacttac  cagaacctg  attttggtg  tcaatagca  attatgaat  900
aaatcagag  gttggagaa  ccttccatg  atcacagcc  tcactcact  tagatggct  960
tacagaccc  tcaaattca  agaggttct  cttaggttt  ctctccaat  ttaaccgaa  1020
tgccacggt  gaaatgaca  gaaggcata  aggaagagg  gtgcgctta  actacatag  1080
tggggaagt  tttgctgag  gcctaagtg  tagtgcaat  tttgtgcag  gccccaatt  1140
taatcagag  tatggctgg  accctgcaa  agtgtgtaa  attccacca  gctgtaatc  1200
gaagatctt  aacaaccag  aatttgctg  tcttctggc  cagtctgtt  atcagggtt  1260
tgaagccgt  tatcagcta  ctagaatgt  caccataag  atgagtttt  tgaaagggt  1320
gggagcaga  taccgaagg  agacggtaa  aagtactcc  tgctggatt  aacttcatc  1380
gaatggacc  ctacagtgg  tggacaaag  attaactca  atgggatcc  cttcagtgc  1440
ttgctcaag  atgtcataa  gcttcacca  tcaagtccc  tggaaaaga  ttaatgtaa  1500
aactcttct  ttcattagc  ttgtgttgt  gtccctatg  ctgtttact  tccaaaagt  1560
caagagaga  aacagcact  gaggtctca  caattaaag  accttgtgg  atctgtttc  1620
tatatttga  tattagatg  gaaaattag  gtctagaaa  actctccca  taaagagga  1680
gagaagatt  taaagactt  atgatgtct  attgggcat  aaactgagt  tcccaaagg  1740
ttattaata  cagtagtag  tatgtgtac  ggtaatgta  catgatcca  tatcacagt  1800
ttgtgctgt  tatatacat  tttagtttg  atagatgag  tgtgtgtgt  cgctgcttc  1860
tgatctagg  aaaccttta  aaagttgca  tacctaatc  gttattccc  cttctctgt  1920
atttttgtg  gtctttttt  atatataat  tatatcaag  ttttcaaat  atttagaag  1980
agattttcc  gtagaaaaa  taatttttc  gccttttac  aaaaataaa  tcttgggga  2040
g  2041



<210> 304
<211> 467
<212> PRT
<213> Homo sapiens
<308> Q15796
<400> 304

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
  1               5                  10                  15
Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
             20                  25                  30
Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
         35                  40                  45
Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
     50                  55                  60
Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Ser Thr 
 65                  70                  75                  80
Cys Ser Glu Ile Trp Gly Leu Ser Thr Pro Asn Thr Ile Asp Gln Trp 
                 85                  90                  95
Asp Thr Thr Gly Leu Tyr Ser Phe Ser Glu Gln Thr Arg Ser Leu Asp 
             100                105                110
Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr 
         115                120                125
Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu Leu Lys 
     130                135                140
Ala Ile Glu Asn Cys Glu Tyr Ala Phe Asn Leu Lys Lys Asp Glu Val 
 145                150                155                160
Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val Leu Pro 
                 165                170                175
Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu Pro Pro 
             180                185                190
Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe Pro Ala 
         195                200                205
Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro Pro Gly 
     210                215                220
Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn Gln Ser 
 225                230                235                240
Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu Ser Pro 
                 245                250                255
Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu Pro Ala 
             260                265                270
Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu 
         275                280                285
Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp 
     290                295                300
Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn 
 305                310                315                320
Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val 
                 325                330                335
Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp 
             340                345                350
Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp 
         355                360                365
His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile 
     370                375                380
Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln 
 385                390                395                400
Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met 
                 405                410                415
Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr 
             420                425                430
Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp 
         435                440                445
Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser 
     450                455                460
Ser Met Ser 
 465



<210> 305
<211> 1942
<212> DNA
<213> Rattus norvegicus
<308> AB017912
<400> 305

ggagcagct  gctcgcctg  agctcgcga  cgctgagcg  gccgcccga  gggtagatt  60
accaggctg  ttctgagtg  ggattgtta  ccttggtaa  aaaatgtcg  ccatcttgc  120
attcactcc  ccagtggtg  agagacttc  gggatggaa  aaatcagcc  gtgggtctg  180
aggagcagg  ggtggagaa  agaatggac  ggaagaaaa  tggtgtgaa  aagcagtga  240
aagtctggt  aaaaagcta  agaaaacag  acgattaga  gagcttgag  aagccatca  300
cactcagaa  tgcaatact  agtgtgtca  cataccaag  acttgctct  aaatttggg  360
actgagtac  gcaaatacg  tagatcagt  ggacacaac  ggcctttac  gcttctctg  420
acaaaccag  tctcttgat  gtcgtcttc  ggtgtctca  cggaaaggg  tgccacatg  480
tatatattg  cggctgtgg  gctggccag  ccttcacag  catcatgag  tcaaggcga  540
cgagaactg  gaatacgct  tcagtctga  aaaagatga  gtgtgtgtg  acccttacc  600
ctaccagag  gtggagaca  cagtcttgc  tccagtctt  gtgcctcgg  acacagaga  660
tctaacaga  ctgccgcct  tggatgact  tacccactc  attccagaa  acacaaatt  720
cccagcagg  attgagcca  agagtaatt  catcccaga  acaccacca  ctggatata  780
cagtgaaga  ggagaaact  gtgaccaac  gttgaacca  agtatggac  caggctctc  840
ggctgaact  tctcctacc  ctctctccc  tgtcaatca  agcttggat  tgcagccag  900
tacttattc  gaacctgca  tttggtgtt  aatcgcata  tatgaacta  accagaggg  960
tggagagac  ttccatgcg  cacagccct  actcactgt  gacggcttt  cagatccat  1020
gaactcgga  aggttctgc  taggtttgc  ctccaacgt  aacagaaac  ctactgtag  1080
aatgaccag  aggcatata  gaaggggag  gcgcttgta  tacataggt  gggaagtgt  1140
tgccgagtg  ctaagtgat  gtgcgatct  tgtgcagag  cccaactgt  accagagat  1200
cggctggca  cccgcgaca  tgtgcaaaa  cccaccagg  tgtaacctg  agatcttca  1260
caaccaaga  tttgctgct  ttctggctc  gtctgttaa  cagggtttt  aggccgttt  1320
tcagctgac  cgaatgtgc  ccataagaa  gagcttcgt  aaggggtgg  gagcagaat  1380
ccggaggca  acagtaaca  gtactcctt  ctggattga  cttcatctg  atggccccc  1440
gcagtggtt  gacaaagta  taactcaga  gggatcccc  tcagtgcga  gctcaagca  1500
gtcctaaag  ccgtcagca  tggagctca  tggaagact  aacgtacca  ctcctccgc  1560
acagtactc  tgtgtgatc  cgtggactg  gctagtcaa  acccagagc  aaaacagca  1620
ttgaggtct  atcagttaa  gcaccttgt  gagtctgtt  cctacattt  aattttaga  1680
gggaaatta  tgtctagaa  tgccctccc  agaggggac  aagaagact  aaagactta  1740
tgatgtttc  ttgggcata  gacagtgtc  caaaggtta  taataccag  agtagttgt  1800
tacagtaac  tgtccagac  cagtattgc  gtgctctgc  gtttgtata  cttcttagt  1860
tgcataaat  aggtgtgtg  tgctgcttg  tctaggcaa  cctttataa  attacagta  1920
ctaatctgt  attcccaaa  aa  1942



<210> 306
<211> 467
<212> PRT
<213> Rattus norvegicus
<308> O70436
<400> 306

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
  1               5                  10                  15
Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
             20                  25                  30
Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
         35                  40                  45
Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
     50                  55                  60
Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Ser Thr 
 65                  70                  75                  80
Cys Ser Glu Ile Trp Gly Leu Ser Thr Ala Asn Thr Val Asp Gln Trp 
                 85                  90                  95
Asp Thr Thr Gly Leu Tyr Ser Phe Ser Glu Gln Thr Arg Ser Leu Asp 
             100                105                110
Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr 
         115                120                125
Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu Leu Lys 
     130                135                140
Ala Ile Glu Asn Cys Glu Tyr Ala Phe Ser Leu Lys Lys Asp Glu Val 
 145                150                155                160
Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val Leu Pro 
                 165                170                175
Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu Pro Pro 
             180                185                190
Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe Pro Ala 
         195                200                205
Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro Pro Gly 
     210                215                220
Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn Gln Ser 
 225                230                235                240
Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu Ser Pro 
                 245                250                255
Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu Pro Ala 
             260                265                270
Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu 
         275                280                285
Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp 
     290                295                300
Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn 
 305                310                315                320
Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val 
                 325                330                335
Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp 
             340                345                350
Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp 
         355                360                365
His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile 
     370                375                380
Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln 
 385                390                395                400
Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met 
                 405                410                415
Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr 
             420                425                430
Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp 
         435                440                445
Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser 
     450                455                460
Ser Met Ser 
 465



<210> 307
<211> 2041
<212> DNA
<213> Homo sapiens
<308> U68018
<400> 307

aggttcgat  caagaggct  ttttcctag  gtggcttgc  gcctttggt  agaacatgt  60
gtccatctt  ccattcacg  cgccagttg  gaagagact  ctgggatgg  agaagtcag  120
tggtgggtc  ggaggagca  gcggaggag  gcagaatgg  caggaagaa  agtggtgtg  180
gaaagcagt  aaaagtctg  tgaagaagc  aaagaaaac  ggacgatta  atgagcttg  240
gaaagccat  accactcaa  actgtaata  taaatgtgt  accatacca  gcacttgct  300
tgaaatttg  ggactgagt  caccaaata  gatagatca  tgggataca  caggccttt  360
cagcttctc  gaacaaacc  ggtctcttg  tggtcgtct  caggtatcc  atcgaaaag  420
attgccaca  gttatatat  gccgattat  gcgctggcc  gatcttcac  gtcatcatg  480
actcaaggc  attgaaaac  gcgaatatg  ttttaatct  aaaaaggat  aagtatgtg  540
aaaccctta  cactatcag  gagttgaga  accagtttt  cctccagta  tagtgcccc  600
acacaccga  atcctaaca  aacttccgc  tctggatga  tatactcac  ccattccag  660
aaacactaa  ttcccagca  gaattgagc  acagagtaa  tatattcca  aaacgccac  720
tcctggata  atcagtgaa  atggagaaa  aagtgacca  cagttgaat  aaagtatgg  780
cacaggctc  ccagcagaa  tatctccta  tactctttc  cctgttaat  atagcttgg  840
tttacagcc  gttacttac  cagaacctg  attttggtg  tcaatagca  attatgaat  900
aaatcagag  gttggagaa  ccttccatg  atcacagcc  tcactcact  tagatggct  960
tacagaccc  tcaaattca  agaggttct  cttaggttt  ctctccaat  ttaaccgaa  1020
tgccacggt  gaaatgaca  gaaggcata  aggaagagg  gtgcgctta  actacatag  1080
tggggaagt  tttgctgag  gcctaagtg  tagtgcaat  tttgtgcag  gccccaatt  1140
taatcagag  tatggctgg  accctgcaa  agtgtgtaa  attccacca  gctgtaatc  1200
gaagatctt  aacaaccag  aatttgctg  tcttctggc  cagtctgtt  atcagggtt  1260
tgaagccgt  tatcagcta  ctagaatgt  caccataag  atgagtttt  tgaaagggt  1320
gggagcaga  taccgaagg  agacggtaa  aagtactcc  tgctggatt  aacttcatc  1380
gaatggacc  ctacagtgg  tggacaaag  attaactca  atgggatcc  cttcagtgc  1440
ttgctcaag  atgtcataa  gcttcacca  tcaagtccc  tggaaaaga  ttaatgtaa  1500
aactcttct  ttcattagc  ttgtgttgt  gtccctatg  ctgtttact  tccaaaagt  1560
caagagaga  aacagcact  gaggtctca  caattaaag  accttgtgg  atctgtttc  1620
tatatttga  tattagatg  gaaaattag  gtctagaaa  actctccca  taaagagga  1680
gagaagatt  taaagactt  atgatgtct  attgggcat  aaactgagt  tcccaaagg  1740
ttattaata  cagtagtag  tatgtgtac  ggtaatgta  catgatcca  tatcacagt  1800
ttgtgctgt  tatatacat  tttagtttg  atagatgag  tgtgtgtgt  cgctgcttc  1860
tgatctagg  aaaccttta  aaagttgca  tacctaatc  gttattccc  cttctctgt  1920
atttttgtg  gtctttttt  atatataat  tatatcaag  ttttcaaat  atttagaag  1980
agattttcc  gtagaaaaa  taatttttc  gccttttac  aaaaataaa  tcttgggga  2040
g  2041



<210> 308
<211> 467
<212> PRT
<213> Homo sapiens
<308> Q15796
<400> 308

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
  1               5                  10                  15
Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
             20                  25                  30
Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
         35                  40                  45
Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
     50                  55                  60
Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Ser Thr 
 65                  70                  75                  80
Cys Ser Glu Ile Trp Gly Leu Ser Thr Pro Asn Thr Ile Asp Gln Trp 
                 85                  90                  95
Asp Thr Thr Gly Leu Tyr Ser Phe Ser Glu Gln Thr Arg Ser Leu Asp 
             100                105                110
Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr 
         115                120                125
Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu Leu Lys 
     130                135                140
Ala Ile Glu Asn Cys Glu Tyr Ala Phe Asn Leu Lys Lys Asp Glu Val 
 145                150                155                160
Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val Leu Pro 
                 165                170                175
Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu Pro Pro 
             180                185                190
Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe Pro Ala 
         195                200                205
Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro Pro Gly 
     210                215                220
Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn Gln Ser 
 225                230                235                240
Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu Ser Pro 
                 245                250                255
Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu Pro Ala 
             260                265                270
Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu 
         275                280                285
Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp 
     290                295                300
Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn 
 305                310                315                320
Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val 
                 325                330                335
Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp 
             340                345                350
Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp 
         355                360                365
His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile 
     370                375                380
Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln 
 385                390                395                400
Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met 
                 405                410                415
Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr 
             420                425                430
Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp 
         435                440                445
Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser 
     450                455                460
Ser Met Ser 
 465



<210> 309
<211> 1942
<212> DNA
<213> Rattus norvegicus
<308> AB017912
<400> 309

ggagcagct  gctcgcctg  agctcgcga  cgctgagcg  gccgcccga  gggtagatt  60
accaggctg  ttctgagtg  ggattgtta  ccttggtaa  aaaatgtcg  ccatcttgc  120
attcactcc  ccagtggtg  agagacttc  gggatggaa  aaatcagcc  gtgggtctg  180
aggagcagg  ggtggagaa  agaatggac  ggaagaaaa  tggtgtgaa  aagcagtga  240
aagtctggt  aaaaagcta  agaaaacag  acgattaga  gagcttgag  aagccatca  300
cactcagaa  tgcaatact  agtgtgtca  cataccaag  acttgctct  aaatttggg  360
actgagtac  gcaaatacg  tagatcagt  ggacacaac  ggcctttac  gcttctctg  420
acaaaccag  tctcttgat  gtcgtcttc  ggtgtctca  cggaaaggg  tgccacatg  480
tatatattg  cggctgtgg  gctggccag  ccttcacag  catcatgag  tcaaggcga  540
cgagaactg  gaatacgct  tcagtctga  aaaagatga  gtgtgtgtg  acccttacc  600
ctaccagag  gtggagaca  cagtcttgc  tccagtctt  gtgcctcgg  acacagaga  660
tctaacaga  ctgccgcct  tggatgact  tacccactc  attccagaa  acacaaatt  720
cccagcagg  attgagcca  agagtaatt  catcccaga  acaccacca  ctggatata  780
cagtgaaga  ggagaaact  gtgaccaac  gttgaacca  agtatggac  caggctctc  840
ggctgaact  tctcctacc  ctctctccc  tgtcaatca  agcttggat  tgcagccag  900
tacttattc  gaacctgca  tttggtgtt  aatcgcata  tatgaacta  accagaggg  960
tggagagac  ttccatgcg  cacagccct  actcactgt  gacggcttt  cagatccat  1020
gaactcgga  aggttctgc  taggtttgc  ctccaacgt  aacagaaac  ctactgtag  1080
aatgaccag  aggcatata  gaaggggag  gcgcttgta  tacataggt  gggaagtgt  1140
tgccgagtg  ctaagtgat  gtgcgatct  tgtgcagag  cccaactgt  accagagat  1200
cggctggca  cccgcgaca  tgtgcaaaa  cccaccagg  tgtaacctg  agatcttca  1260
caaccaaga  tttgctgct  ttctggctc  gtctgttaa  cagggtttt  aggccgttt  1320
tcagctgac  cgaatgtgc  ccataagaa  gagcttcgt  aaggggtgg  gagcagaat  1380
ccggaggca  acagtaaca  gtactcctt  ctggattga  cttcatctg  atggccccc  1440
gcagtggtt  gacaaagta  taactcaga  gggatcccc  tcagtgcga  gctcaagca  1500
gtcctaaag  ccgtcagca  tggagctca  tggaagact  aacgtacca  ctcctccgc  1560
acagtactc  tgtgtgatc  cgtggactg  gctagtcaa  acccagagc  aaaacagca  1620
ttgaggtct  atcagttaa  gcaccttgt  gagtctgtt  cctacattt  aattttaga  1680
gggaaatta  tgtctagaa  tgccctccc  agaggggac  aagaagact  aaagactta  1740
tgatgtttc  ttgggcata  gacagtgtc  caaaggtta  taataccag  agtagttgt  1800
tacagtaac  tgtccagac  cagtattgc  gtgctctgc  gtttgtata  cttcttagt  1860
tgcataaat  aggtgtgtg  tgctgcttg  tctaggcaa  cctttataa  attacagta  1920
ctaatctgt  attcccaaa  aa  1942



<210> 310
<211> 467
<212> PRT
<213> Rattus norvegicus
<308> O70436
<400> 310

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
  1               5                  10                  15
Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
             20                  25                  30
Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
         35                  40                  45
Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
     50                  55                  60
Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Ser Thr 
 65                  70                  75                  80
Cys Ser Glu Ile Trp Gly Leu Ser Thr Ala Asn Thr Val Asp Gln Trp 
                 85                  90                  95
Asp Thr Thr Gly Leu Tyr Ser Phe Ser Glu Gln Thr Arg Ser Leu Asp 
             100                105                110
Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr 
         115                120                125
Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu Leu Lys 
     130                135                140
Ala Ile Glu Asn Cys Glu Tyr Ala Phe Ser Leu Lys Lys Asp Glu Val 
 145                150                155                160
Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val Leu Pro 
                 165                170                175
Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu Pro Pro 
             180                185                190
Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe Pro Ala 
         195                200                205
Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro Pro Gly 
     210                215                220
Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn Gln Ser 
 225                230                235                240
Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu Ser Pro 
                 245                250                255
Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu Pro Ala 
             260                265                270
Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu 
         275                280                285
Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp 
     290                295                300
Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn 
 305                310                315                320
Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val 
                 325                330                335
Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp 
             340                345                350
Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp 
         355                360                365
His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile 
     370                375                380
Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln 
 385                390                395                400
Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met 
                 405                410                415
Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr 
             420                425                430
Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp 
         435                440                445
Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser 
     450                455                460
Ser Met Ser 
 465



<210> 311
<211> 2041
<212> DNA
<213> Homo sapiens
<308> U68018
<400> 311

aggttcgat  caagaggct  ttttcctag  gtggcttgc  gcctttggt  agaacatgt  60
gtccatctt  ccattcacg  cgccagttg  gaagagact  ctgggatgg  agaagtcag  120
tggtgggtc  ggaggagca  gcggaggag  gcagaatgg  caggaagaa  agtggtgtg  180
gaaagcagt  aaaagtctg  tgaagaagc  aaagaaaac  ggacgatta  atgagcttg  240
gaaagccat  accactcaa  actgtaata  taaatgtgt  accatacca  gcacttgct  300
tgaaatttg  ggactgagt  caccaaata  gatagatca  tgggataca  caggccttt  360
cagcttctc  gaacaaacc  ggtctcttg  tggtcgtct  caggtatcc  atcgaaaag  420
attgccaca  gttatatat  gccgattat  gcgctggcc  gatcttcac  gtcatcatg  480
actcaaggc  attgaaaac  gcgaatatg  ttttaatct  aaaaaggat  aagtatgtg  540
aaaccctta  cactatcag  gagttgaga  accagtttt  cctccagta  tagtgcccc  600
acacaccga  atcctaaca  aacttccgc  tctggatga  tatactcac  ccattccag  660
aaacactaa  ttcccagca  gaattgagc  acagagtaa  tatattcca  aaacgccac  720
tcctggata  atcagtgaa  atggagaaa  aagtgacca  cagttgaat  aaagtatgg  780
cacaggctc  ccagcagaa  tatctccta  tactctttc  cctgttaat  atagcttgg  840
tttacagcc  gttacttac  cagaacctg  attttggtg  tcaatagca  attatgaat  900
aaatcagag  gttggagaa  ccttccatg  atcacagcc  tcactcact  tagatggct  960
tacagaccc  tcaaattca  agaggttct  cttaggttt  ctctccaat  ttaaccgaa  1020
tgccacggt  gaaatgaca  gaaggcata  aggaagagg  gtgcgctta  actacatag  1080
tggggaagt  tttgctgag  gcctaagtg  tagtgcaat  tttgtgcag  gccccaatt  1140
taatcagag  tatggctgg  accctgcaa  agtgtgtaa  attccacca  gctgtaatc  1200
gaagatctt  aacaaccag  aatttgctg  tcttctggc  cagtctgtt  atcagggtt  1260
tgaagccgt  tatcagcta  ctagaatgt  caccataag  atgagtttt  tgaaagggt  1320
gggagcaga  taccgaagg  agacggtaa  aagtactcc  tgctggatt  aacttcatc  1380
gaatggacc  ctacagtgg  tggacaaag  attaactca  atgggatcc  cttcagtgc  1440
ttgctcaag  atgtcataa  gcttcacca  tcaagtccc  tggaaaaga  ttaatgtaa  1500
aactcttct  ttcattagc  ttgtgttgt  gtccctatg  ctgtttact  tccaaaagt  1560
caagagaga  aacagcact  gaggtctca  caattaaag  accttgtgg  atctgtttc  1620
tatatttga  tattagatg  gaaaattag  gtctagaaa  actctccca  taaagagga  1680
gagaagatt  taaagactt  atgatgtct  attgggcat  aaactgagt  tcccaaagg  1740
ttattaata  cagtagtag  tatgtgtac  ggtaatgta  catgatcca  tatcacagt  1800
ttgtgctgt  tatatacat  tttagtttg  atagatgag  tgtgtgtgt  cgctgcttc  1860
tgatctagg  aaaccttta  aaagttgca  tacctaatc  gttattccc  cttctctgt  1920
atttttgtg  gtctttttt  atatataat  tatatcaag  ttttcaaat  atttagaag  1980
agattttcc  gtagaaaaa  taatttttc  gccttttac  aaaaataaa  tcttgggga  2040
g  2041



<210> 312
<211> 467
<212> PRT
<213> Homo sapiens
<308> Q15796
<400> 312

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
  1               5                  10                  15
Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
             20                  25                  30
Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
         35                  40                  45
Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
     50                  55                  60
Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Ser Thr 
 65                  70                  75                  80
Cys Ser Glu Ile Trp Gly Leu Ser Thr Pro Asn Thr Ile Asp Gln Trp 
                 85                  90                  95
Asp Thr Thr Gly Leu Tyr Ser Phe Ser Glu Gln Thr Arg Ser Leu Asp 
             100                105                110
Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr 
         115                120                125
Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu Leu Lys 
     130                135                140
Ala Ile Glu Asn Cys Glu Tyr Ala Phe Asn Leu Lys Lys Asp Glu Val 
 145                150                155                160
Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val Leu Pro 
                 165                170                175
Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu Pro Pro 
             180                185                190
Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe Pro Ala 
         195                200                205
Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro Pro Gly 
     210                215                220
Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn Gln Ser 
 225                230                235                240
Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu Ser Pro 
                 245                250                255
Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu Pro Ala 
             260                265                270
Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu 
         275                280                285
Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp 
     290                295                300
Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn 
 305                310                315                320
Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val 
                 325                330                335
Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp 
             340                345                350
Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp 
         355                360                365
His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile 
     370                375                380
Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln 
 385                390                395                400
Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met 
                 405                410                415
Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr 
             420                425                430
Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp 
         435                440                445
Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser 
     450                455                460
Ser Met Ser 
 465



<210> 313
<211> 1942
<212> DNA
<213> Rattus norvegicus
<308> AB017912
<400> 313

ggagcagct  gctcgcctg  agctcgcga  cgctgagcg  gccgcccga  gggtagatt  60
accaggctg  ttctgagtg  ggattgtta  ccttggtaa  aaaatgtcg  ccatcttgc  120
attcactcc  ccagtggtg  agagacttc  gggatggaa  aaatcagcc  gtgggtctg  180
aggagcagg  ggtggagaa  agaatggac  ggaagaaaa  tggtgtgaa  aagcagtga  240
aagtctggt  aaaaagcta  agaaaacag  acgattaga  gagcttgag  aagccatca  300
cactcagaa  tgcaatact  agtgtgtca  cataccaag  acttgctct  aaatttggg  360
actgagtac  gcaaatacg  tagatcagt  ggacacaac  ggcctttac  gcttctctg  420
acaaaccag  tctcttgat  gtcgtcttc  ggtgtctca  cggaaaggg  tgccacatg  480
tatatattg  cggctgtgg  gctggccag  ccttcacag  catcatgag  tcaaggcga  540
cgagaactg  gaatacgct  tcagtctga  aaaagatga  gtgtgtgtg  acccttacc  600
ctaccagag  gtggagaca  cagtcttgc  tccagtctt  gtgcctcgg  acacagaga  660
tctaacaga  ctgccgcct  tggatgact  tacccactc  attccagaa  acacaaatt  720
cccagcagg  attgagcca  agagtaatt  catcccaga  acaccacca  ctggatata  780
cagtgaaga  ggagaaact  gtgaccaac  gttgaacca  agtatggac  caggctctc  840
ggctgaact  tctcctacc  ctctctccc  tgtcaatca  agcttggat  tgcagccag  900
tacttattc  gaacctgca  tttggtgtt  aatcgcata  tatgaacta  accagaggg  960
tggagagac  ttccatgcg  cacagccct  actcactgt  gacggcttt  cagatccat  1020
gaactcgga  aggttctgc  taggtttgc  ctccaacgt  aacagaaac  ctactgtag  1080
aatgaccag  aggcatata  gaaggggag  gcgcttgta  tacataggt  gggaagtgt  1140
tgccgagtg  ctaagtgat  gtgcgatct  tgtgcagag  cccaactgt  accagagat  1200
cggctggca  cccgcgaca  tgtgcaaaa  cccaccagg  tgtaacctg  agatcttca  1260
caaccaaga  tttgctgct  ttctggctc  gtctgttaa  cagggtttt  aggccgttt  1320
tcagctgac  cgaatgtgc  ccataagaa  gagcttcgt  aaggggtgg  gagcagaat  1380
ccggaggca  acagtaaca  gtactcctt  ctggattga  cttcatctg  atggccccc  1440
gcagtggtt  gacaaagta  taactcaga  gggatcccc  tcagtgcga  gctcaagca  1500
gtcctaaag  ccgtcagca  tggagctca  tggaagact  aacgtacca  ctcctccgc  1560
acagtactc  tgtgtgatc  cgtggactg  gctagtcaa  acccagagc  aaaacagca  1620
ttgaggtct  atcagttaa  gcaccttgt  gagtctgtt  cctacattt  aattttaga  1680
gggaaatta  tgtctagaa  tgccctccc  agaggggac  aagaagact  aaagactta  1740
tgatgtttc  ttgggcata  gacagtgtc  caaaggtta  taataccag  agtagttgt  1800
tacagtaac  tgtccagac  cagtattgc  gtgctctgc  gtttgtata  cttcttagt  1860
tgcataaat  aggtgtgtg  tgctgcttg  tctaggcaa  cctttataa  attacagta  1920
ctaatctgt  attcccaaa  aa  1942



<210> 314
<211> 467
<212> PRT
<213> Rattus norvegicus
<308> O70436
<400> 314

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
  1               5                  10                  15
Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
             20                  25                  30
Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
         35                  40                  45
Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
     50                  55                  60
Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Ser Thr 
 65                  70                  75                  80
Cys Ser Glu Ile Trp Gly Leu Ser Thr Ala Asn Thr Val Asp Gln Trp 
                 85                  90                  95
Asp Thr Thr Gly Leu Tyr Ser Phe Ser Glu Gln Thr Arg Ser Leu Asp 
             100                105                110
Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr 
         115                120                125
Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu Leu Lys 
     130                135                140
Ala Ile Glu Asn Cys Glu Tyr Ala Phe Ser Leu Lys Lys Asp Glu Val 
 145                150                155                160
Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val Leu Pro 
                 165                170                175
Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu Pro Pro 
             180                185                190
Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe Pro Ala 
         195                200                205
Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro Pro Gly 
     210                215                220
Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn Gln Ser 
 225                230                235                240
Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu Ser Pro 
                 245                250                255
Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu Pro Ala 
             260                265                270
Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu 
         275                280                285
Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp 
     290                295                300
Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn 
 305                310                315                320
Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val 
                 325                330                335
Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp 
             340                345                350
Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp 
         355                360                365
His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile 
     370                375                380
Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln 
 385                390                395                400
Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met 
                 405                410                415
Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr 
             420                425                430
Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp 
         435                440                445
Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser 
     450                455                460
Ser Met Ser 
 465



<210> 315
<211> 2041
<212> DNA
<213> Homo sapiens
<308> U68018
<400> 315

aggttcgat  caagaggct  ttttcctag  gtggcttgc  gcctttggt  agaacatgt  60
gtccatctt  ccattcacg  cgccagttg  gaagagact  ctgggatgg  agaagtcag  120
tggtgggtc  ggaggagca  gcggaggag  gcagaatgg  caggaagaa  agtggtgtg  180
gaaagcagt  aaaagtctg  tgaagaagc  aaagaaaac  ggacgatta  atgagcttg  240
gaaagccat  accactcaa  actgtaata  taaatgtgt  accatacca  gcacttgct  300
tgaaatttg  ggactgagt  caccaaata  gatagatca  tgggataca  caggccttt  360
cagcttctc  gaacaaacc  ggtctcttg  tggtcgtct  caggtatcc  atcgaaaag  420
attgccaca  gttatatat  gccgattat  gcgctggcc  gatcttcac  gtcatcatg  480
actcaaggc  attgaaaac  gcgaatatg  ttttaatct  aaaaaggat  aagtatgtg  540
aaaccctta  cactatcag  gagttgaga  accagtttt  cctccagta  tagtgcccc  600
acacaccga  atcctaaca  aacttccgc  tctggatga  tatactcac  ccattccag  660
aaacactaa  ttcccagca  gaattgagc  acagagtaa  tatattcca  aaacgccac  720
tcctggata  atcagtgaa  atggagaaa  aagtgacca  cagttgaat  aaagtatgg  780
cacaggctc  ccagcagaa  tatctccta  tactctttc  cctgttaat  atagcttgg  840
tttacagcc  gttacttac  cagaacctg  attttggtg  tcaatagca  attatgaat  900
aaatcagag  gttggagaa  ccttccatg  atcacagcc  tcactcact  tagatggct  960
tacagaccc  tcaaattca  agaggttct  cttaggttt  ctctccaat  ttaaccgaa  1020
tgccacggt  gaaatgaca  gaaggcata  aggaagagg  gtgcgctta  actacatag  1080
tggggaagt  tttgctgag  gcctaagtg  tagtgcaat  tttgtgcag  gccccaatt  1140
taatcagag  tatggctgg  accctgcaa  agtgtgtaa  attccacca  gctgtaatc  1200
gaagatctt  aacaaccag  aatttgctg  tcttctggc  cagtctgtt  atcagggtt  1260
tgaagccgt  tatcagcta  ctagaatgt  caccataag  atgagtttt  tgaaagggt  1320
gggagcaga  taccgaagg  agacggtaa  aagtactcc  tgctggatt  aacttcatc  1380
gaatggacc  ctacagtgg  tggacaaag  attaactca  atgggatcc  cttcagtgc  1440
ttgctcaag  atgtcataa  gcttcacca  tcaagtccc  tggaaaaga  ttaatgtaa  1500
aactcttct  ttcattagc  ttgtgttgt  gtccctatg  ctgtttact  tccaaaagt  1560
caagagaga  aacagcact  gaggtctca  caattaaag  accttgtgg  atctgtttc  1620
tatatttga  tattagatg  gaaaattag  gtctagaaa  actctccca  taaagagga  1680
gagaagatt  taaagactt  atgatgtct  attgggcat  aaactgagt  tcccaaagg  1740
ttattaata  cagtagtag  tatgtgtac  ggtaatgta  catgatcca  tatcacagt  1800
ttgtgctgt  tatatacat  tttagtttg  atagatgag  tgtgtgtgt  cgctgcttc  1860
tgatctagg  aaaccttta  aaagttgca  tacctaatc  gttattccc  cttctctgt  1920
atttttgtg  gtctttttt  atatataat  tatatcaag  ttttcaaat  atttagaag  1980
agattttcc  gtagaaaaa  taatttttc  gccttttac  aaaaataaa  tcttgggga  2040
g  2041



<210> 316
<211> 467
<212> PRT
<213> Homo sapiens
<308> Q15796
<400> 316

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
  1               5                  10                  15
Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
             20                  25                  30
Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
         35                  40                  45
Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
     50                  55                  60
Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Ser Thr 
 65                  70                  75                  80
Cys Ser Glu Ile Trp Gly Leu Ser Thr Pro Asn Thr Ile Asp Gln Trp 
                 85                  90                  95
Asp Thr Thr Gly Leu Tyr Ser Phe Ser Glu Gln Thr Arg Ser Leu Asp 
             100                105                110
Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr 
         115                120                125
Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu Leu Lys 
     130                135                140
Ala Ile Glu Asn Cys Glu Tyr Ala Phe Asn Leu Lys Lys Asp Glu Val 
 145                150                155                160
Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val Leu Pro 
                 165                170                175
Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu Pro Pro 
             180                185                190
Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe Pro Ala 
         195                200                205
Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro Pro Gly 
     210                215                220
Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn Gln Ser 
 225                230                235                240
Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu Ser Pro 
                 245                250                255
Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu Pro Ala 
             260                265                270
Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu 
         275                280                285
Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp 
     290                295                300
Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn 
 305                310                315                320
Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val 
                 325                330                335
Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp 
             340                345                350
Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp 
         355                360                365
His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile 
     370                375                380
Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln 
 385                390                395                400
Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met 
                 405                410                415
Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr 
             420                425                430
Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp 
         435                440                445
Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser 
     450                455                460
Ser Met Ser 
 465



<210> 317
<211> 2044
<212> DNA
<213> Rattus norvegicus
<308> AB019393
<400> 317

ctgagcagg  ccacccatc  agacacctt  cagcagagc  ttctagaag  agcctcacc  60
agccttcat  ccgatgccc  cctgtgcac  ctgctgcag  tgcggtccc  agatgccag  120
tctccagct  ctgtttctg  cctgcctgg  atggggaat  ggggccagg  cagcacagt  180
ccgaaaggc  aacgatcgg  gtggtcgat  ccagtacac  ttcactgtg  ccagcccca  240
tgaatctag  tgcccaagg  aggaccagg  catgtcagc  atccaggac  ttcagagag  300
tagcagcat  cagcatgca  acctagagt  caccaaggc  cgggtcaga  ccctggaga  360
tctcctcca  cagatgacc  caggcggag  tactgggac  caggaggtc  aggaggggc  420
acaaggcca  ctgggtgcc  tgaggagag  gcgggacca  ctggagacc  aaaccaggg  480
tctggaggt  gcctataac  atctcctga  agacaaatc  gctttggag  aagagaaga  540
gcagctgga  caagagaat  aagatttgg  caggaggct  gaaggcagc  gccaggagg  600
agcaaggct  aggagaggc  agtgtccct  aacccacca  ccctctcag  acatgttgc  660
aggctccag  gaagtctct  agtggaatt  ggacacgtt  gctttccag  aactgaagt  720
agaactaac  gaggttcct  cttcccaaa  cttgaagaa  caatctggt  atcccagga  780
caaagaggg  gacaaagga  gtggagtgc  aatgtgggt  ggagagcca  tcaccctga  840
gacagctga  acaatcact  gaaagtatg  agtatggat  agagacccc  agcccactc  900
cccctacac  caggagacc  cttggagga  tgacacggt  ggcacaggc  tccgccagg  960
gtttgagta  agtcagata  gccagttcg  gcagggcta  ccttcaaag  tccatgtgc  1020
cccccaggc  ctggaaagc  caggtgctg  ggtgtatgc  gggagcctg  atttccagg  1080
tgctgagtc  agaactgtg  tcaggtatg  actgaacac  gaaacagtg  aggcagaga  1140
ggaaattcc  ggagctggc  accatggac  gttcccata  gcatggggt  gctacacag  1200
catcgactt  gctgtggat  agagcggcc  ctgggtcat  tatagcaca  aggaaacca  1260
aggagccat  gtcctctcc  aattgaacc  agagaacct  gaacttgag  gtacctggg  1320
gaccaacat  cgtaagcag  ctgtggcta  tgcctttgt  atctgtggc  tcttgtaca  1380
ggtgagcag  tactcttca  tccatgcaa  catcaactt  gcctatgac  ctaacactg  1440
gatcagcaa  accctgacc  tcccattca  gaatcgcta  aaatacagc  gcatggtcg  1500
ctacaaccc  ctggagagg  aactctttg  ctgggacaa  ttcaacatg  tcacctatg  1560
tatcaagct  tcagagatg  gaggagcct  tatccctac  agagaaggc  gaaaaaggg  1620
gaagttcca  gctcccagg  gaagcagct  caanaggag  cagccagat  ctgggggct  1680
ctgcttctc  agattttgt  tgtccaggt  aatacctcg  ggcttgtac  gttgcatat  1740
ttctgctct  ttctgtcag  tttcaaagg  gtgttcatc  tttaaaaat  atatagtgt  1800
gcagtccag  gaaaaacta  aagtgttgt  tcctcatga  accattgct  ttgcaagct  1860
tatggttac  acaaacctt  agaggcagc  acagttcta  caagaggag  gagataacg  1920
ggagggggt  accaccact  ctgtggtta  aactgctcc  gcagtattt  ctccagttt  1980
taaggctac  gatatagca  gtacattaa  ccctttgcc  tgtgaaata  agttatctt  2040
cacg  2044



<210> 318
<211> 502
<212> PRT
<213> Rattus norvegicus
<308> Q9R1J4
<400> 318

Met Pro Ser Cys Ala Tyr Cys Cys Ser Cys Gly Pro Lys Met Pro Ala 
  1               5                  10                  15
Leu Gln Leu Leu Phe Leu Ala Cys Leu Val Trp Gly Met Gly Ala Arg 
             20                  25                  30
Thr Ala Gln Phe Arg Lys Ala Asn Asp Arg Ser Gly Arg Cys Gln Tyr 
         35                  40                  45
Thr Phe Thr Val Ala Ser Pro Ser Glu Ser Ser Cys Pro Arg Glu Asp 
     50                  55                  60
Gln Ala Met Ser Ala Ile Gln Asp Leu Gln Arg Asp Ser Ser Ile Gln 
 65                  70                  75                  80
His Ala Asp Leu Glu Ser Thr Lys Ala Arg Val Arg Ser Leu Glu Ser 
                 85                  90                  95
Leu Leu His Gln Met Thr Ser Gly Gly Val Thr Gly Thr Gln Glu Val 
             100                105                110
Gln Glu Gly Leu Gln Gly Gln Leu Gly Ala Leu Arg Arg Glu Arg Asp 
         115                120                125
Gln Leu Glu Thr Gln Thr Arg Asp Leu Glu Val Ala Tyr Asn Asn Leu 
     130                135                140
Leu Arg Asp Lys Ser Ala Leu Glu Glu Glu Lys Arg Gln Leu Glu Gln 
 145                150                155                160
Glu Asn Lys Asp Leu Ala Arg Arg Leu Glu Gly Ser Ser Gln Glu Val 
                 165                170                175
Ala Arg Leu Arg Arg Gly Gln Cys Pro Ser Thr His His Pro Ser Gln 
             180                185                190
Asp Met Leu Pro Gly Ser Arg Glu Val Ser Gln Trp Asn Leu Asp Thr 
         195                200                205
Leu Ala Phe Gln Glu Leu Lys Ser Glu Leu Thr Glu Val Pro Ala Ser 
     210                215                220
Gln Ile Leu Lys Asn Gln Ser Gly His Pro Arg Ser Lys Glu Gly Asp 
 225                230                235                240
Lys Gly Cys Gly Val Leu Met Trp Val Gly Glu Pro Val Thr Leu Arg 
                 245                250                255
Thr Ala Glu Thr Ile Thr Gly Lys Tyr Gly Val Trp Met Arg Asp Pro 
             260                265                270
Lys Pro Thr His Pro Tyr Thr Gln Glu Thr Thr Trp Arg Ile Asp Thr 
         275                280                285
Val Gly Thr Gly Ile Arg Gln Val Phe Glu Tyr Ser Gln Ile Ser Gln 
     290                295                300
Phe Glu Gln Gly Tyr Pro Ser Lys Val His Val Leu Pro Gln Ala Leu 
 305                310                315                320
Glu Ser Thr Gly Ala Val Val Tyr Ser Gly Ser Leu Tyr Phe Gln Gly 
                 325                330                335
Ala Glu Ser Arg Thr Val Leu Arg Tyr Glu Leu Asn Thr Glu Thr Val 
             340                345                350
Lys Ala Glu Lys Glu Ile Pro Gly Ala Gly Tyr His Gly Gln Phe Pro 
         355                360                365
Tyr Ala Trp Gly Gly Tyr Thr Asp Ile Asp Leu Ala Val Asp Glu Ser 
     370                375                380
Gly Leu Trp Val Ile Tyr Ser Thr Glu Glu Thr Arg Gly Ala Ile Val 
 385                390                395                400
Leu Ser Lys Leu Asn Pro Glu Asn Leu Glu Leu Glu Ser Thr Trp Glu 
                 405                410                415
Thr Asn Ile Arg Lys Gln Ser Val Ala Asn Ala Phe Val Ile Cys Gly 
             420                425                430
Ile Leu Tyr Thr Val Ser Ser Tyr Ser Ser Val His Ala Thr Ile Asn 
         435                440                445
Phe Ala Tyr Asp Thr Asn Thr Gly Ile Ser Lys Thr Leu Thr Ile Pro 
     450                455                460
Phe Lys Asn Arg Tyr Lys Tyr Ser Ser Met Val Asp Tyr Asn Pro Leu 
 465                470                475                480
Glu Arg Lys Leu Phe Ala Trp Asp Asn Phe Asn Met Val Thr Tyr Asp 
                 485                490                495
Ile Lys Leu Ser Glu Met 
             500



<210> 319
<211> 2000
<212> DNA
<213> Homo sapiens
<308> U85257
<400> 319

agagctttc  agaggaagc  tcaccaagc  tctgcaatg  ggttcttct  tgcacgttg  60
tgcagcttt  ggcctgaga  gccagctgt  cagctgctg  ttctggcct  cctggtgtg  120
gatgtgggg  ccaggacag  tcagctcag  aaggccaat  accagagtg  ccgatgcca  180
tataccttc  gtgtggcca  tcccaatga  tccagctgc  cagagcaga  ccaggccat  240
tcagtcatc  ataacttac  gagagacag  agcacccaa  gcttagacc  ggaggccac  300
aaagctcga  tcagctccc  ggagagcct  ctccaccaa  tgaccttgg  ccaggctgc  360
aggccccag  agacccagg  ggggctgca  agggagctg  gcaccctga  gcgggagcg  420
gaccagctg  aaacccaaa  cagagagtt  gagactgcc  acagcaacc  cctccgaga  480
aagtcagtt  tggaggaag  gaagaagcg  ctaaggcaa  aaaatgaga  tctggccag  540
aggttggaa  gcagcagcc  ggaggtagc  aggctgaga  ggggccagt  tccccagac  600
cgagacact  ctcgggctg  gccaccagg  tccagagaa  tttctacgt  gaatttgga  660
actttggcc  tccaggaac  gaagtccga  ctaactgaa  ttcctgctt  ccgaatttt  720
aaggagagc  catctggct  tctcaggag  ggagaggga  acaccggat  tggagaact  780
gtttgggta  gagagcctc  cacgctgag  acagcagaa  caattactg  caagtatgg  840
gtgtggatg  gagacccca  gcccaccta  ccctacacc  aggagacca  gtggagaat  900
gacacagtt  gcacggatg  ccgccaggt  tttgagtat  acctcatca  ccagtttat  960
cagggctac  cttctaagg  tcacatact  cctaggcca  tggaaagca  gggtgctgt  1020
gtgtactcg  ggagcctct  tttccaggg  gctgagtcc  gaactgtca  aagatatga  1080
ctgaatacc  agacagtga  ggctgagaa  gaaatccct  gagctggct  ccacggaca  1140
ttcccgtat  cttggggtg  ctacacgga  attgacttg  ctgtggatg  agcaggcct  1200
tgggtcatt  acagcaccg  tgaggccaa  ggtgccatt  tcctctcca  actgaaccc  1260
gagaatctg  aactcgaac  aacctggga  acaaacatc  gtaagcagt  agtcgccaa  1320
gccttcatc  tctgtggca  cttgtacac  gtcagcagc  acacctcag  agatgctac  1380
gtcaacttt  cttatgaca  aggcacagg  atcagcaag  ccctgacca  cccattcaa  1440
aaccgctat  agtacagca  catgattga  tacaacccc  tggagaaga  gctctttgc  1500
tgggacaac  tgaacatgg  cacttatga  atcaagctc  ccaagatgt  aaaagcctc  1560
aagctgtac  ggcaatggc  gaaggagat  ctcagggct  ctgggggga  caggctgaa  1620
ggagagcca  ccagccagg  cccaggcag  tttgactgc  ttccaagtt  tcattaatc  1680
agaaggatg  acatggtca  catctaact  ttcaggaat  gtagtctga  ggcgtagac  1740
atttcatat  ataaatatc  tttatcttc  gtcagcatt  atgggatgt  taatgacat  1800
gttcaagtt  tcttgtgat  tggggcaaa  gctgtaagg  ataatagtt  cttcctgaa  1860
aaccattgc  cttgcatgt  acatggtta  cacaagcca  aataaaaag  ataacttct  1920
aaggaagca  aatagctcc  ctggccagc  tcgaatata  gtaagatgc  tttactaca  1980
ttggcttct  atgcttcaga  2000



<210> 320
<211> 504
<212> PRT
<213> Homo sapiens
<308> Q99972
<400> 320

Met Arg Phe Phe Cys Ala Arg Cys Cys Ser Phe Gly Pro Glu Met Pro 
  1               5                  10                  15
Ala Val Gln Leu Leu Leu Leu Ala Cys Leu Val Trp Asp Val Gly Ala 
             20                  25                  30
Arg Thr Ala Gln Leu Arg Lys Ala Asn Asp Gln Ser Gly Arg Cys Gln 
         35                  40                  45
Tyr Thr Phe Ser Val Ala Ser Pro Asn Glu Ser Ser Cys Pro Glu Gln 
     50                  55                  60
Ser Gln Ala Met Ser Val Ile His Asn Leu Gln Arg Asp Ser Ser Thr 
 65                  70                  75                  80
Gln Arg Leu Asp Leu Glu Ala Thr Lys Ala Arg Leu Ser Ser Leu Glu 
                 85                  90                  95
Ser Leu Leu His Gln Leu Thr Leu Asp Gln Ala Ala Arg Pro Gln Glu 
             100                105                110
Thr Gln Glu Gly Leu Gln Arg Glu Leu Gly Thr Leu Arg Arg Glu Arg 
         115                120                125
Asp Gln Leu Glu Thr Gln Thr Arg Glu Leu Glu Thr Ala Tyr Ser Asn 
     130                135                140
Leu Leu Arg Asp Lys Ser Val Leu Glu Glu Glu Lys Lys Arg Leu Arg 
 145                150                155                160
Gln Glu Asn Glu Asn Leu Ala Arg Arg Leu Glu Ser Ser Ser Gln Glu 
                 165                170                175
Val Ala Arg Leu Arg Arg Gly Gln Cys Pro Gln Thr Arg Asp Thr Ala 
             180                185                190
Arg Ala Val Pro Pro Gly Ser Arg Glu Val Ser Thr Trp Asn Leu Asp 
         195                200                205
Thr Leu Ala Phe Gln Glu Leu Lys Ser Glu Leu Thr Glu Val Pro Ala 
     210                215                220
Ser Arg Ile Leu Lys Glu Ser Pro Ser Gly Tyr Leu Arg Ser Gly Glu 
 225                230                235                240
Gly Asp Thr Gly Cys Gly Glu Leu Val Trp Val Gly Glu Pro Leu Thr 
                 245                250                255
Leu Arg Thr Ala Glu Thr Ile Thr Gly Lys Tyr Gly Val Trp Met Arg 
             260                265                270
Asp Pro Lys Pro Thr Tyr Pro Tyr Thr Gln Glu Thr Thr Trp Arg Ile 
         275                280                285
Asp Thr Val Gly Thr Asp Val Arg Gln Val Phe Glu Tyr Asp Leu Ile 
     290                295                300
Ser Gln Phe Met Gln Gly Tyr Pro Ser Lys Val His Ile Leu Pro Arg 
 305                310                315                320
Pro Leu Glu Ser Thr Gly Ala Val Val Tyr Ser Gly Ser Leu Tyr Phe 
                 325                330                335
Gln Gly Ala Glu Ser Arg Thr Val Ile Arg Tyr Glu Leu Asn Thr Glu 
             340                345                350
Thr Val Lys Ala Glu Lys Glu Ile Pro Gly Ala Gly Tyr His Gly Gln 
         355                360                365
Phe Pro Tyr Ser Trp Gly Gly Tyr Thr Asp Ile Asp Leu Ala Val Asp 
     370                375                380
Glu Ala Gly Leu Trp Val Ile Tyr Ser Thr Asp Glu Ala Lys Gly Ala 
 385                390                395                400
Ile Val Leu Ser Lys Leu Asn Pro Glu Asn Leu Glu Leu Glu Gln Thr 
                 405                410                415
Trp Glu Thr Asn Ile Arg Lys Gln Ser Val Ala Asn Ala Phe Ile Ile 
             420                425                430
Cys Gly Thr Leu Tyr Thr Val Ser Ser Tyr Thr Ser Ala Asp Ala Thr 
         435                440                445
Val Asn Phe Ala Tyr Asp Thr Gly Thr Gly Ile Ser Lys Thr Leu Thr 
     450                455                460
Ile Pro Phe Lys Asn Arg Tyr Lys Tyr Ser Ser Met Ile Asp Tyr Asn 
 465                470                475                480
Pro Leu Glu Lys Lys Leu Phe Ala Trp Asp Asn Leu Asn Met Val Thr 
                 485                490                495
Tyr Asp Ile Lys Leu Ser Lys Met 
             500



<210> 321
<211> 853
<212> DNA
<213> Rattus norvegicus
<308> AB020504
<400> 321

ggccacgcg  cgactagta  ggggggggg  ggggaatga  gcggaccat  tgaccccgc  60
cgctcgctc  acgcgctgg  acgggagcg  cagccaact  cagagcgaa  tcctctcac  120
ccagtcact  agagcaatg  aactgtaac  gttgttttc  caaatactg  acgatggta  180
gactgacca  caacttcct  ttgttttgt  ttatatata  ctttaaaat  tcttgtcag  240
tttactatg  atgttcatc  attcaccaa  gccctcaaa  agaagtttc  ccacagaac  300
ggcacctca  gctctgtcc  aaggaatgt  ttttaattt  tgcccggat  aaagaaaat  360
agctttgca  acactctcg  ttctttatt  gcaggcaaa  ttcactctt  attatctga  420
acttttcca  tctcagcct  ttagaggca  agatggctc  agtttcagt  gcaaaaaag  480
ctttttttt  ttttctttc  gtaaccaaa  tagagcaaa  ttggaattc  gtctgggac  540
aaaacgtca  agcagaaaa  aaatgaaaa  aaaataatt  gctttttct  tctttcatt  600
agcagcata  ataagtttg  ccactggga  tacagtaca  gggttggga  aacgatccc  660
tatttgaag  cctacttct  gcaccagca  caagaacta  atccacctc  ggactcaca  720
aacccagga  aacttgcca  ctttgagca  catatgcat  gaagagtgt  tatagaagc  780
acagtaaat  gattaacag  ggctaatac  gtgattgat  gacattggc  atggttggc  840
aaaaaaaaa  aaa  853



<210> 322
<211> 81
<212> PRT
<213> Rattus norvegicus
<308> BAA34715
<400> 322

Met Val Arg Leu Thr Ser Asn Phe Leu Leu Phe Cys Ile Ile Tyr Ile 
  1               5                  10                  15
Phe Lys Ile Ser Cys Gln Phe Tyr Tyr Val Cys Ser Ser Ile His Gln 
             20                  25                  30
Ser Pro Gln Lys Glu Val Ser Pro Gln Asn Arg His Leu Arg Leu Cys 
         35                  40                  45
Pro Lys Glu Cys Val Leu Ile Phe Ala Arg Ile Lys Glu Asn Lys Leu 
     50                  55                  60
Cys Thr His Ser Arg Phe Phe Ile Cys Arg Gln Thr Ser Leu Phe Ile 
 65                  70                  75                  80
Ile 
                 85



<210> 323
<211> 3571
<212> DNA
<213> Homo sapiens
<308> AY008274
<400> 323

ctcagcagg  caggacatt  ggtagggga  ggttgaaag  caaaagcag  aggccttgg  60
ttctcagcc  tttaaaaac  attattaaa  atatatttt  aaaatttag  ggttagagc  120
tttagtaat  tgcctgtat  acatgtaga  agtattcgt  aaccaagag  agttttaaa  180
tgtcaaaac  gggaaaacc  actctaaac  atggcttgg  tcctgttga  cttaaaagt  240
caaaagagc  tctaccaca  caaaccgtg  tgaagatat  tagcattag  atcattgcc  300
aaggcctcc  tttttgtcg  agacggatg  aaagaaagt  ggaccatgg  tctgaggtc  360
gctcttttt  tttgggaaa  aaaccatgc  aagtctcag  atatacaag  accactggg  420
ttgtaccat  ttcagcaac  ccaacaact  ttggggacc  cagagcagc  aatggccaa  480
ggcaacaac  acgccgaat  acatctgtc  agccaccta  aggcctcca  gaatggcta  540
aaatgtttc  gagctggag  ggaccagag  aattgcttg  tttagatga  ctcattgat  600
gttgtgaac  aacacaagt  aaacatatg  tgcaagtga  agaacccca  tttcaacga  660
acttcattt  attgctccc  aaagagttg  cactctatg  gctttcatt  ctggaaccc  720
aagacctgc  acaagcagc  cagacatgt  gctactgga  aattttggc  gaagacaac  780
ttctctgga  agagaaatg  aaagaagag  ggattgatg  accattgca  atcaagaga  840
gaaaagtaa  aaaaccagg  ttcatacac  gtccatgga  aagtgcata  atcagacag  900
acagaattg  tactaactg  aggcgagga  aactcaaat  tcctaaggt  ctgaaagga  960
atgatgatc  tgtgatcac  tgcttacag  tttgtggta  ccgaatagt  agtggttct  1020
atgacaaca  tttaaaagt  tggtcagca  tcacaggca  atgtctgag  acattagtg  1080
gacatacag  tggagtatg  tcatcacaa  tgagagaca  catcatcat  agtggatct  1140
cagatcgga  actcaaagt  tggaatgca  agactggag  atgtataca  accttatat  1200
ggcatactt  cactgtgcg  tgtatgcat  ttcatgaaa  aagagttgt  agcggttct  1260
gagatgcca  tcttagggt  tgggatatt  agacaggcc  gtgtttaca  gttttgatg  1320
gtcatgttg  agcagtccg  tgtgttcaa  atgatggca  gagggttgt  agtggagca  1380
atgatttta  ggtaaaggt  tgggatcca  agactgaaa  ctgtctaca  acgttgcag  1440
ggcatacta  tagagtcta  tcattacag  ttgatggta  ccatgtggt  agtggatct  1500
ttgatacat  aatccgtgt  tgggatgtg  agacaggga  ttgcattca  acgttaaca  1560
ggcaccagt  gttaacaag  ggaatggaa  tcaaagaca  tattcttgt  tctgggaat  1620
cagattcta  agttaaaat  tgggatatc  aaacaggac  gtgtttaca  acattgcaa  1680
gtcccaaca  gcatcagag  gctgtgacc  gtttacagt  caacaagaa  tttgtaatt  1740
ccagctcag  tgatggaac  gtaaaacta  gggacttga  aacgggtga  tttattcga  1800
acctagtca  attggagag  ggggggagt  ggggagttg  gtggcggat  agagcctca  1860
acacaaagc  ggtgtgtgc  gttgggagt  ggaatggga  tgaagaaac  aagctgctg  1920
tgctggact  tgatgtgga  atgaagtga  gagcagaaa  gatgaattt  tccaattgt  1980
tagacgata  actccctgc  cttccccct  caaaaagaa  aaaagaaaa  aaaaagaaa  2040
aaatccctt  ttctcagtg  tgcaggatg  tggcttggg  caacagatt  aaaagacct  2100
cagactaag  aggaaaaga  gaagagatg  caaaccata  ctgacaaga  aggcgtctg  2160
tgtctcatc  cataaaagg  ttcactttt  actgagggc  gctttgcaa  atgagactt  2220
ctaaatcaa  ccaggtgca  ttatttctt  attttcttc  ccagtggtc  ttggggcag  2280
gttaatgct  aaacatcat  acagattct  ctagcctgt  cttttacca  tgacagcta  2340
acacctaga  aggaactgc  ataatatca  aacaagtac  ggttgactt  ctaattaga  2400
agcatctgc  acaaaaagt  atttttctg  agtggaaaa  cttaaaaaa  ttactgtga  2460
ttgtttttg  acagttatc  tgaaaagct  tttttttta  tttttngcc  accattgcc  2520
atgtcaatc  atcacagta  tagcctctg  taatctatt  actgttgct  ccatataca  2580
tcttcaatg  atatgttgc  caaaggtgg  aagttgtcc  gggttctgt  agtcctgag  2640
tggatttaa  tcttgatgc  ggtgctaga  gtaggtctt  aaatatggg  ttgttgtcc  2700
aaccctgta  tgtactccc  gtggccaaa  ttatttatg  tgctaaatg  aagaaagaa  2760
aaagcaaat  atttttttt  ttttttttc  gctgtgacg  tttagtccc  gactgaatt  2820
caaatttgc  ctagtttgg  tatggaaaa  agacttttt  ccactgaaa  ttgagccat  2880
tgtgcctct  agaggctga  aatggaaga  tttcagata  taaagagtg  agtttgcct  2940
caagtaaag  attgagagt  tgtgcaaag  ttattttct  ttatctggg  aaaaattaa  3000
acacattcc  tggaacaga  ctattactt  cctgttctg  ggagaaact  ttctttttg  3060
gggctgtgg  gaatggatg  acgtacatc  taaaactga  aaaatattt  aaaaatata  3120
aaaacacaa  attaaaata  agttgctgg  cagtcttag  gttttacag  atttgggaa  3180
acaactgtt  cagttttat  gctctgagt  actgacaaa  cagaaacta  tcagttttt  3240
tagtaaagg  gtcacatgc  aacaaacaa  atgaatgaa  cagtcaaat  gtttgcctc  3300
ttctccaag  gccacaact  aagctgaac  gtgaaagtg  tttaacact  tatcctagg  3360
gatcttttt  cctccttct  tttattttt  tgnttgttt  atttatagt  tgatttaaa  3420
caatcagat  caagttggt  aattttagt  atgtaacaa  ctgacatga  ggaggaaaa  3480
aacctttaa  gggattgtg  ctatggttt  attcactta  aaattttat  ttcttataa  3540
ttaagtgca  taaaatgtg  tttttcatg  t  3571



<210> 324
<211> 590
<212> PRT
<213> Homo sapiens
<308> AY008274
<400> 324

Met Ser Lys Pro Gly Lys Pro Thr Leu Asn His Gly Leu Val Pro Val 
  1               5                  10                  15
Asp Leu Lys Ser Ala Lys Glu Pro Leu Pro His Gln Thr Val Met Lys 
             20                  25                  30
Ile Phe Ser Ile Ser Ile Ile Ala Gln Gly Leu Pro Phe Cys Arg Arg 
         35                  40                  45
Arg Met Lys Arg Lys Leu Asp His Gly Ser Glu Val Arg Ser Phe Ser 
     50                  55                  60
Leu Gly Lys Lys Pro Cys Lys Val Ser Glu Tyr Thr Ser Thr Thr Gly 
 65                  70                  75                  80
Leu Val Pro Cys Ser Ala Thr Pro Thr Thr Phe Gly Asp Leu Arg Ala 
                 85                  90                  95
Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg Ile Thr Ser Val Gln Pro 
             100                105                110
Pro Thr Gly Leu Gln Glu Trp Leu Lys Met Phe Gln Ser Trp Ser Gly 
         115                120                125
Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu Ile Asp Ser Cys Glu Pro 
     130                135                140
Thr Gln Val Lys His Met Met Gln Val Ile Glu Pro Gln Phe Gln Arg 
 145                150                155                160
Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu Ala Leu Tyr Val Leu Ser 
                 165                170                175
Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala Ala Gln Thr Cys Arg Tyr 
             180                185                190
Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu Trp Arg Glu Lys Cys Lys 
         195                200                205
Glu Glu Gly Ile Asp Glu Pro Leu His Ile Lys Arg Arg Lys Val Ile 
     210                215                220
Lys Pro Gly Phe Ile His Ser Pro Trp Lys Ser Ala Tyr Ile Arg Gln 
 225                230                235                240
His Arg Ile Asp Thr Asn Trp Arg Arg Gly Glu Leu Lys Ser Pro Lys 
                 245                250                255
Val Leu Lys Gly His Asp Asp His Val Ile Thr Cys Leu Gln Phe Cys 
             260                265                270
Gly Asn Arg Ile Val Ser Gly Ser Asp Asp Asn Thr Leu Lys Val Trp 
         275                280                285
Ser Ala Val Thr Gly Lys Cys Leu Arg Thr Leu Val Gly His Thr Gly 
     290                295                300
Gly Val Trp Ser Ser Gln Met Arg Asp Asn Ile Ile Ile Ser Gly Ser 
 305                310                315                320
Thr Asp Arg Thr Leu Lys Val Trp Asn Ala Glu Thr Gly Glu Cys Ile 
                 325                330                335
His Thr Leu Tyr Gly His Thr Ser Thr Val Arg Cys Met His Leu His 
             340                345                350
Glu Lys Arg Val Val Ser Gly Ser Arg Asp Ala Thr Leu Arg Val Trp 
         355                360                365
Asp Ile Glu Thr Gly Gln Cys Leu His Val Leu Met Gly His Val Ala 
     370                375                380
Ala Val Arg Cys Val Gln Tyr Asp Gly Arg Arg Val Val Ser Gly Ala 
 385                390                395                400
Tyr Asp Phe Met Val Lys Val Trp Asp Pro Glu Thr Glu Thr Cys Leu 
                 405                410                415
His Thr Leu Gln Gly His Thr Asn Arg Val Tyr Ser Leu Gln Phe Asp 
             420                425                430
Gly Ile His Val Val Ser Gly Ser Leu Asp Thr Ser Ile Arg Val Trp 
         435                440                445
Asp Val Glu Thr Gly Asn Cys Ile His Thr Leu Thr Gly His Gln Ser 
     450                455                460
Leu Thr Ser Gly Met Glu Leu Lys Asp Asn Ile Leu Val Ser Gly Asn 
 465                470                475                480
Ala Asp Ser Thr Val Lys Ile Trp Asp Ile Lys Thr Gly Gln Cys Leu 
                 485                490                495
Gln Thr Leu Gln Gly Pro Asn Lys His Gln Ser Ala Val Thr Cys Leu 
             500                505                510
Gln Phe Asn Lys Asn Phe Val Ile Thr Ser Ser Asp Asp Gly Thr Val 
         515                520                525
Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe Ile Arg Asn Leu Val Thr 
     530                535                540
Leu Glu Ser Gly Gly Ser Gly Gly Val Val Trp Arg Ile Arg Ala Ser 
 545                550                555                560
Asn Thr Lys Leu Val Cys Ala Val Gly Ser Arg Asn Gly Thr Glu Glu 
                 565                570                575
Thr Lys Leu Leu Val Leu Asp Phe Asp Val Asp Met Lys Ter 
             580                585                590



<210> 325
<211> 853
<212> DNA
<213> Rattus norvegicus
<308> AB020504
<400> 325

ggccacgcg  cgactagta  ggggggggg  ggggaatga  gcggaccat  tgaccccgc  60
cgctcgctc  acgcgctgg  acgggagcg  cagccaact  cagagcgaa  tcctctcac  120
ccagtcact  agagcaatg  aactgtaac  gttgttttc  caaatactg  acgatggta  180
gactgacca  caacttcct  ttgttttgt  ttatatata  ctttaaaat  tcttgtcag  240
tttactatg  atgttcatc  attcaccaa  gccctcaaa  agaagtttc  ccacagaac  300
ggcacctca  gctctgtcc  aaggaatgt  ttttaattt  tgcccggat  aaagaaaat  360
agctttgca  acactctcg  ttctttatt  gcaggcaaa  ttcactctt  attatctga  420
acttttcca  tctcagcct  ttagaggca  agatggctc  agtttcagt  gcaaaaaag  480
ctttttttt  ttttctttc  gtaaccaaa  tagagcaaa  ttggaattc  gtctgggac  540
aaaacgtca  agcagaaaa  aaatgaaaa  aaaataatt  gctttttct  tctttcatt  600
agcagcata  ataagtttg  ccactggga  tacagtaca  gggttggga  aacgatccc  660
tatttgaag  cctacttct  gcaccagca  caagaacta  atccacctc  ggactcaca  720
aacccagga  aacttgcca  ctttgagca  catatgcat  gaagagtgt  tatagaagc  780
acagtaaat  gattaacag  ggctaatac  gtgattgat  gacattggc  atggttggc  840
aaaaaaaaa  aaa  853



<210> 326
<211> 81
<212> PRT
<213> Rattus norvegicus
<308> BAA34715
<400> 326

Met Val Arg Leu Thr Ser Asn Phe Leu Leu Phe Cys Ile Ile Tyr Ile 
  1               5                  10                  15
Phe Lys Ile Ser Cys Gln Phe Tyr Tyr Val Cys Ser Ser Ile His Gln 
             20                  25                  30
Ser Pro Gln Lys Glu Val Ser Pro Gln Asn Arg His Leu Arg Leu Cys 
         35                  40                  45
Pro Lys Glu Cys Val Leu Ile Phe Ala Arg Ile Lys Glu Asn Lys Leu 
     50                  55                  60
Cys Thr His Ser Arg Phe Phe Ile Cys Arg Gln Thr Ser Leu Phe Ile 
 65                  70                  75                  80
Ile 
                 85



<210> 327
<211> 3571
<212> DNA
<213> Homo sapiens
<308> AY008274
<400> 327

ctcagcagg  caggacatt  ggtagggga  ggttgaaag  caaaagcag  aggccttgg  60
ttctcagcc  tttaaaaac  attattaaa  atatatttt  aaaatttag  ggttagagc  120
tttagtaat  tgcctgtat  acatgtaga  agtattcgt  aaccaagag  agttttaaa  180
tgtcaaaac  gggaaaacc  actctaaac  atggcttgg  tcctgttga  cttaaaagt  240
caaaagagc  tctaccaca  caaaccgtg  tgaagatat  tagcattag  atcattgcc  300
aaggcctcc  tttttgtcg  agacggatg  aaagaaagt  ggaccatgg  tctgaggtc  360
gctcttttt  tttgggaaa  aaaccatgc  aagtctcag  atatacaag  accactggg  420
ttgtaccat  ttcagcaac  ccaacaact  ttggggacc  cagagcagc  aatggccaa  480
ggcaacaac  acgccgaat  acatctgtc  agccaccta  aggcctcca  gaatggcta  540
aaatgtttc  gagctggag  ggaccagag  aattgcttg  tttagatga  ctcattgat  600
gttgtgaac  aacacaagt  aaacatatg  tgcaagtga  agaacccca  tttcaacga  660
acttcattt  attgctccc  aaagagttg  cactctatg  gctttcatt  ctggaaccc  720
aagacctgc  acaagcagc  cagacatgt  gctactgga  aattttggc  gaagacaac  780
ttctctgga  agagaaatg  aaagaagag  ggattgatg  accattgca  atcaagaga  840
gaaaagtaa  aaaaccagg  ttcatacac  gtccatgga  aagtgcata  atcagacag  900
acagaattg  tactaactg  aggcgagga  aactcaaat  tcctaaggt  ctgaaagga  960
atgatgatc  tgtgatcac  tgcttacag  tttgtggta  ccgaatagt  agtggttct  1020
atgacaaca  tttaaaagt  tggtcagca  tcacaggca  atgtctgag  acattagtg  1080
gacatacag  tggagtatg  tcatcacaa  tgagagaca  catcatcat  agtggatct  1140
cagatcgga  actcaaagt  tggaatgca  agactggag  atgtataca  accttatat  1200
ggcatactt  cactgtgcg  tgtatgcat  ttcatgaaa  aagagttgt  agcggttct  1260
gagatgcca  tcttagggt  tgggatatt  agacaggcc  gtgtttaca  gttttgatg  1320
gtcatgttg  agcagtccg  tgtgttcaa  atgatggca  gagggttgt  agtggagca  1380
atgatttta  ggtaaaggt  tgggatcca  agactgaaa  ctgtctaca  acgttgcag  1440
ggcatacta  tagagtcta  tcattacag  ttgatggta  ccatgtggt  agtggatct  1500
ttgatacat  aatccgtgt  tgggatgtg  agacaggga  ttgcattca  acgttaaca  1560
ggcaccagt  gttaacaag  ggaatggaa  tcaaagaca  tattcttgt  tctgggaat  1620
cagattcta  agttaaaat  tgggatatc  aaacaggac  gtgtttaca  acattgcaa  1680
gtcccaaca  gcatcagag  gctgtgacc  gtttacagt  caacaagaa  tttgtaatt  1740
ccagctcag  tgatggaac  gtaaaacta  gggacttga  aacgggtga  tttattcga  1800
acctagtca  attggagag  ggggggagt  ggggagttg  gtggcggat  agagcctca  1860
acacaaagc  ggtgtgtgc  gttgggagt  ggaatggga  tgaagaaac  aagctgctg  1920
tgctggact  tgatgtgga  atgaagtga  gagcagaaa  gatgaattt  tccaattgt  1980
tagacgata  actccctgc  cttccccct  caaaaagaa  aaaagaaaa  aaaaagaaa  2040
aaatccctt  ttctcagtg  tgcaggatg  tggcttggg  caacagatt  aaaagacct  2100
cagactaag  aggaaaaga  gaagagatg  caaaccata  ctgacaaga  aggcgtctg  2160
tgtctcatc  cataaaagg  ttcactttt  actgagggc  gctttgcaa  atgagactt  2220
ctaaatcaa  ccaggtgca  ttatttctt  attttcttc  ccagtggtc  ttggggcag  2280
gttaatgct  aaacatcat  acagattct  ctagcctgt  cttttacca  tgacagcta  2340
acacctaga  aggaactgc  ataatatca  aacaagtac  ggttgactt  ctaattaga  2400
agcatctgc  acaaaaagt  atttttctg  agtggaaaa  cttaaaaaa  ttactgtga  2460
ttgtttttg  acagttatc  tgaaaagct  tttttttta  tttttngcc  accattgcc  2520
atgtcaatc  atcacagta  tagcctctg  taatctatt  actgttgct  ccatataca  2580
tcttcaatg  atatgttgc  caaaggtgg  aagttgtcc  gggttctgt  agtcctgag  2640
tggatttaa  tcttgatgc  ggtgctaga  gtaggtctt  aaatatggg  ttgttgtcc  2700
aaccctgta  tgtactccc  gtggccaaa  ttatttatg  tgctaaatg  aagaaagaa  2760
aaagcaaat  atttttttt  ttttttttc  gctgtgacg  tttagtccc  gactgaatt  2820
caaatttgc  ctagtttgg  tatggaaaa  agacttttt  ccactgaaa  ttgagccat  2880
tgtgcctct  agaggctga  aatggaaga  tttcagata  taaagagtg  agtttgcct  2940
caagtaaag  attgagagt  tgtgcaaag  ttattttct  ttatctggg  aaaaattaa  3000
acacattcc  tggaacaga  ctattactt  cctgttctg  ggagaaact  ttctttttg  3060
gggctgtgg  gaatggatg  acgtacatc  taaaactga  aaaatattt  aaaaatata  3120
aaaacacaa  attaaaata  agttgctgg  cagtcttag  gttttacag  atttgggaa  3180
acaactgtt  cagttttat  gctctgagt  actgacaaa  cagaaacta  tcagttttt  3240
tagtaaagg  gtcacatgc  aacaaacaa  atgaatgaa  cagtcaaat  gtttgcctc  3300
ttctccaag  gccacaact  aagctgaac  gtgaaagtg  tttaacact  tatcctagg  3360
gatcttttt  cctccttct  tttattttt  tgnttgttt  atttatagt  tgatttaaa  3420
caatcagat  caagttggt  aattttagt  atgtaacaa  ctgacatga  ggaggaaaa  3480
aacctttaa  gggattgtg  ctatggttt  attcactta  aaattttat  ttcttataa  3540
ttaagtgca  taaaatgtg  tttttcatg  t  3571



<210> 328
<211> 590
<212> PRT
<213> Homo sapiens
<308> AY008274
<400> 328

Met Ser Lys Pro Gly Lys Pro Thr Leu Asn His Gly Leu Val Pro Val 
  1               5                  10                  15
Asp Leu Lys Ser Ala Lys Glu Pro Leu Pro His Gln Thr Val Met Lys 
             20                  25                  30
Ile Phe Ser Ile Ser Ile Ile Ala Gln Gly Leu Pro Phe Cys Arg Arg 
         35                  40                  45
Arg Met Lys Arg Lys Leu Asp His Gly Ser Glu Val Arg Ser Phe Ser 
     50                  55                  60
Leu Gly Lys Lys Pro Cys Lys Val Ser Glu Tyr Thr Ser Thr Thr Gly 
 65                  70                  75                  80
Leu Val Pro Cys Ser Ala Thr Pro Thr Thr Phe Gly Asp Leu Arg Ala 
                 85                  90                  95
Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg Ile Thr Ser Val Gln Pro 
             100                105                110
Pro Thr Gly Leu Gln Glu Trp Leu Lys Met Phe Gln Ser Trp Ser Gly 
         115                120                125
Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu Ile Asp Ser Cys Glu Pro 
     130                135                140
Thr Gln Val Lys His Met Met Gln Val Ile Glu Pro Gln Phe Gln Arg 
 145                150                155                160
Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu Ala Leu Tyr Val Leu Ser 
                 165                170                175
Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala Ala Gln Thr Cys Arg Tyr 
             180                185                190
Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu Trp Arg Glu Lys Cys Lys 
         195                200                205
Glu Glu Gly Ile Asp Glu Pro Leu His Ile Lys Arg Arg Lys Val Ile 
     210                215                220
Lys Pro Gly Phe Ile His Ser Pro Trp Lys Ser Ala Tyr Ile Arg Gln 
 225                230                235                240
His Arg Ile Asp Thr Asn Trp Arg Arg Gly Glu Leu Lys Ser Pro Lys 
                 245                250                255
Val Leu Lys Gly His Asp Asp His Val Ile Thr Cys Leu Gln Phe Cys 
             260                265                270
Gly Asn Arg Ile Val Ser Gly Ser Asp Asp Asn Thr Leu Lys Val Trp 
         275                280                285
Ser Ala Val Thr Gly Lys Cys Leu Arg Thr Leu Val Gly His Thr Gly 
     290                295                300
Gly Val Trp Ser Ser Gln Met Arg Asp Asn Ile Ile Ile Ser Gly Ser 
 305                310                315                320
Thr Asp Arg Thr Leu Lys Val Trp Asn Ala Glu Thr Gly Glu Cys Ile 
                 325                330                335
His Thr Leu Tyr Gly His Thr Ser Thr Val Arg Cys Met His Leu His 
             340                345                350
Glu Lys Arg Val Val Ser Gly Ser Arg Asp Ala Thr Leu Arg Val Trp 
         355                360                365
Asp Ile Glu Thr Gly Gln Cys Leu His Val Leu Met Gly His Val Ala 
     370                375                380
Ala Val Arg Cys Val Gln Tyr Asp Gly Arg Arg Val Val Ser Gly Ala 
 385                390                395                400
Tyr Asp Phe Met Val Lys Val Trp Asp Pro Glu Thr Glu Thr Cys Leu 
                 405                410                415
His Thr Leu Gln Gly His Thr Asn Arg Val Tyr Ser Leu Gln Phe Asp 
             420                425                430
Gly Ile His Val Val Ser Gly Ser Leu Asp Thr Ser Ile Arg Val Trp 
         435                440                445
Asp Val Glu Thr Gly Asn Cys Ile His Thr Leu Thr Gly His Gln Ser 
     450                455                460
Leu Thr Ser Gly Met Glu Leu Lys Asp Asn Ile Leu Val Ser Gly Asn 
 465                470                475                480
Ala Asp Ser Thr Val Lys Ile Trp Asp Ile Lys Thr Gly Gln Cys Leu 
                 485                490                495
Gln Thr Leu Gln Gly Pro Asn Lys His Gln Ser Ala Val Thr Cys Leu 
             500                505                510
Gln Phe Asn Lys Asn Phe Val Ile Thr Ser Ser Asp Asp Gly Thr Val 
         515                520                525
Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe Ile Arg Asn Leu Val Thr 
     530                535                540
Leu Glu Ser Gly Gly Ser Gly Gly Val Val Trp Arg Ile Arg Ala Ser 
 545                550                555                560
Asn Thr Lys Leu Val Cys Ala Val Gly Ser Arg Asn Gly Thr Glu Glu 
                 565                570                575
Thr Lys Leu Leu Val Leu Asp Phe Asp Val Asp Met Lys Ter 
             580                585                590



<210> 329
<211> 853
<212> DNA
<213> Rattus norvegicus
<308> AB020504
<400> 329

ggccacgcg  cgactagta  ggggggggg  ggggaatga  gcggaccat  tgaccccgc  60
cgctcgctc  acgcgctgg  acgggagcg  cagccaact  cagagcgaa  tcctctcac  120
ccagtcact  agagcaatg  aactgtaac  gttgttttc  caaatactg  acgatggta  180
gactgacca  caacttcct  ttgttttgt  ttatatata  ctttaaaat  tcttgtcag  240
tttactatg  atgttcatc  attcaccaa  gccctcaaa  agaagtttc  ccacagaac  300
ggcacctca  gctctgtcc  aaggaatgt  ttttaattt  tgcccggat  aaagaaaat  360
agctttgca  acactctcg  ttctttatt  gcaggcaaa  ttcactctt  attatctga  420
acttttcca  tctcagcct  ttagaggca  agatggctc  agtttcagt  gcaaaaaag  480
ctttttttt  ttttctttc  gtaaccaaa  tagagcaaa  ttggaattc  gtctgggac  540
aaaacgtca  agcagaaaa  aaatgaaaa  aaaataatt  gctttttct  tctttcatt  600
agcagcata  ataagtttg  ccactggga  tacagtaca  gggttggga  aacgatccc  660
tatttgaag  cctacttct  gcaccagca  caagaacta  atccacctc  ggactcaca  720
aacccagga  aacttgcca  ctttgagca  catatgcat  gaagagtgt  tatagaagc  780
acagtaaat  gattaacag  ggctaatac  gtgattgat  gacattggc  atggttggc  840
aaaaaaaaa  aaa  853



<210> 330
<211> 81
<212> PRT
<213> Rattus norvegicus
<308> BAA34715
<400> 330

Met Val Arg Leu Thr Ser Asn Phe Leu Leu Phe Cys Ile Ile Tyr Ile 
  1               5                  10                  15
Phe Lys Ile Ser Cys Gln Phe Tyr Tyr Val Cys Ser Ser Ile His Gln 
             20                  25                  30
Ser Pro Gln Lys Glu Val Ser Pro Gln Asn Arg His Leu Arg Leu Cys 
         35                  40                  45
Pro Lys Glu Cys Val Leu Ile Phe Ala Arg Ile Lys Glu Asn Lys Leu 
     50                  55                  60
Cys Thr His Ser Arg Phe Phe Ile Cys Arg Gln Thr Ser Leu Phe Ile 
 65                  70                  75                  80
Ile 
                 85



<210> 331
<211> 3571
<212> DNA
<213> Homo sapiens
<308> AY008274
<400> 331

ctcagcagg  caggacatt  ggtagggga  ggttgaaag  caaaagcag  aggccttgg  60
ttctcagcc  tttaaaaac  attattaaa  atatatttt  aaaatttag  ggttagagc  120
tttagtaat  tgcctgtat  acatgtaga  agtattcgt  aaccaagag  agttttaaa  180
tgtcaaaac  gggaaaacc  actctaaac  atggcttgg  tcctgttga  cttaaaagt  240
caaaagagc  tctaccaca  caaaccgtg  tgaagatat  tagcattag  atcattgcc  300
aaggcctcc  tttttgtcg  agacggatg  aaagaaagt  ggaccatgg  tctgaggtc  360
gctcttttt  tttgggaaa  aaaccatgc  aagtctcag  atatacaag  accactggg  420
ttgtaccat  ttcagcaac  ccaacaact  ttggggacc  cagagcagc  aatggccaa  480
ggcaacaac  acgccgaat  acatctgtc  agccaccta  aggcctcca  gaatggcta  540
aaatgtttc  gagctggag  ggaccagag  aattgcttg  tttagatga  ctcattgat  600
gttgtgaac  aacacaagt  aaacatatg  tgcaagtga  agaacccca  tttcaacga  660
acttcattt  attgctccc  aaagagttg  cactctatg  gctttcatt  ctggaaccc  720
aagacctgc  acaagcagc  cagacatgt  gctactgga  aattttggc  gaagacaac  780
ttctctgga  agagaaatg  aaagaagag  ggattgatg  accattgca  atcaagaga  840
gaaaagtaa  aaaaccagg  ttcatacac  gtccatgga  aagtgcata  atcagacag  900
acagaattg  tactaactg  aggcgagga  aactcaaat  tcctaaggt  ctgaaagga  960
atgatgatc  tgtgatcac  tgcttacag  tttgtggta  ccgaatagt  agtggttct  1020
atgacaaca  tttaaaagt  tggtcagca  tcacaggca  atgtctgag  acattagtg  1080
gacatacag  tggagtatg  tcatcacaa  tgagagaca  catcatcat  agtggatct  1140
cagatcgga  actcaaagt  tggaatgca  agactggag  atgtataca  accttatat  1200
ggcatactt  cactgtgcg  tgtatgcat  ttcatgaaa  aagagttgt  agcggttct  1260
gagatgcca  tcttagggt  tgggatatt  agacaggcc  gtgtttaca  gttttgatg  1320
gtcatgttg  agcagtccg  tgtgttcaa  atgatggca  gagggttgt  agtggagca  1380
atgatttta  ggtaaaggt  tgggatcca  agactgaaa  ctgtctaca  acgttgcag  1440
ggcatacta  tagagtcta  tcattacag  ttgatggta  ccatgtggt  agtggatct  1500
ttgatacat  aatccgtgt  tgggatgtg  agacaggga  ttgcattca  acgttaaca  1560
ggcaccagt  gttaacaag  ggaatggaa  tcaaagaca  tattcttgt  tctgggaat  1620
cagattcta  agttaaaat  tgggatatc  aaacaggac  gtgtttaca  acattgcaa  1680
gtcccaaca  gcatcagag  gctgtgacc  gtttacagt  caacaagaa  tttgtaatt  1740
ccagctcag  tgatggaac  gtaaaacta  gggacttga  aacgggtga  tttattcga  1800
acctagtca  attggagag  ggggggagt  ggggagttg  gtggcggat  agagcctca  1860
acacaaagc  ggtgtgtgc  gttgggagt  ggaatggga  tgaagaaac  aagctgctg  1920
tgctggact  tgatgtgga  atgaagtga  gagcagaaa  gatgaattt  tccaattgt  1980
tagacgata  actccctgc  cttccccct  caaaaagaa  aaaagaaaa  aaaaagaaa  2040
aaatccctt  ttctcagtg  tgcaggatg  tggcttggg  caacagatt  aaaagacct  2100
cagactaag  aggaaaaga  gaagagatg  caaaccata  ctgacaaga  aggcgtctg  2160
tgtctcatc  cataaaagg  ttcactttt  actgagggc  gctttgcaa  atgagactt  2220
ctaaatcaa  ccaggtgca  ttatttctt  attttcttc  ccagtggtc  ttggggcag  2280
gttaatgct  aaacatcat  acagattct  ctagcctgt  cttttacca  tgacagcta  2340
acacctaga  aggaactgc  ataatatca  aacaagtac  ggttgactt  ctaattaga  2400
agcatctgc  acaaaaagt  atttttctg  agtggaaaa  cttaaaaaa  ttactgtga  2460
ttgtttttg  acagttatc  tgaaaagct  tttttttta  tttttngcc  accattgcc  2520
atgtcaatc  atcacagta  tagcctctg  taatctatt  actgttgct  ccatataca  2580
tcttcaatg  atatgttgc  caaaggtgg  aagttgtcc  gggttctgt  agtcctgag  2640
tggatttaa  tcttgatgc  ggtgctaga  gtaggtctt  aaatatggg  ttgttgtcc  2700
aaccctgta  tgtactccc  gtggccaaa  ttatttatg  tgctaaatg  aagaaagaa  2760
aaagcaaat  atttttttt  ttttttttc  gctgtgacg  tttagtccc  gactgaatt  2820
caaatttgc  ctagtttgg  tatggaaaa  agacttttt  ccactgaaa  ttgagccat  2880
tgtgcctct  agaggctga  aatggaaga  tttcagata  taaagagtg  agtttgcct  2940
caagtaaag  attgagagt  tgtgcaaag  ttattttct  ttatctggg  aaaaattaa  3000
acacattcc  tggaacaga  ctattactt  cctgttctg  ggagaaact  ttctttttg  3060
gggctgtgg  gaatggatg  acgtacatc  taaaactga  aaaatattt  aaaaatata  3120
aaaacacaa  attaaaata  agttgctgg  cagtcttag  gttttacag  atttgggaa  3180
acaactgtt  cagttttat  gctctgagt  actgacaaa  cagaaacta  tcagttttt  3240
tagtaaagg  gtcacatgc  aacaaacaa  atgaatgaa  cagtcaaat  gtttgcctc  3300
ttctccaag  gccacaact  aagctgaac  gtgaaagtg  tttaacact  tatcctagg  3360
gatcttttt  cctccttct  tttattttt  tgnttgttt  atttatagt  tgatttaaa  3420
caatcagat  caagttggt  aattttagt  atgtaacaa  ctgacatga  ggaggaaaa  3480
aacctttaa  gggattgtg  ctatggttt  attcactta  aaattttat  ttcttataa  3540
ttaagtgca  taaaatgtg  tttttcatg  t  3571



<210> 332
<211> 590
<212> PRT
<213> Homo sapiens
<308> AY008274
<400> 332

Met Ser Lys Pro Gly Lys Pro Thr Leu Asn His Gly Leu Val Pro Val 
  1               5                  10                  15
Asp Leu Lys Ser Ala Lys Glu Pro Leu Pro His Gln Thr Val Met Lys 
             20                  25                  30
Ile Phe Ser Ile Ser Ile Ile Ala Gln Gly Leu Pro Phe Cys Arg Arg 
         35                  40                  45
Arg Met Lys Arg Lys Leu Asp His Gly Ser Glu Val Arg Ser Phe Ser 
     50                  55                  60
Leu Gly Lys Lys Pro Cys Lys Val Ser Glu Tyr Thr Ser Thr Thr Gly 
 65                  70                  75                  80
Leu Val Pro Cys Ser Ala Thr Pro Thr Thr Phe Gly Asp Leu Arg Ala 
                 85                  90                  95
Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg Ile Thr Ser Val Gln Pro 
             100                105                110
Pro Thr Gly Leu Gln Glu Trp Leu Lys Met Phe Gln Ser Trp Ser Gly 
         115                120                125
Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu Ile Asp Ser Cys Glu Pro 
     130                135                140
Thr Gln Val Lys His Met Met Gln Val Ile Glu Pro Gln Phe Gln Arg 
 145                150                155                160
Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu Ala Leu Tyr Val Leu Ser 
                 165                170                175
Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala Ala Gln Thr Cys Arg Tyr 
             180                185                190
Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu Trp Arg Glu Lys Cys Lys 
         195                200                205
Glu Glu Gly Ile Asp Glu Pro Leu His Ile Lys Arg Arg Lys Val Ile 
     210                215                220
Lys Pro Gly Phe Ile His Ser Pro Trp Lys Ser Ala Tyr Ile Arg Gln 
 225                230                235                240
His Arg Ile Asp Thr Asn Trp Arg Arg Gly Glu Leu Lys Ser Pro Lys 
                 245                250                255
Val Leu Lys Gly His Asp Asp His Val Ile Thr Cys Leu Gln Phe Cys 
             260                265                270
Gly Asn Arg Ile Val Ser Gly Ser Asp Asp Asn Thr Leu Lys Val Trp 
         275                280                285
Ser Ala Val Thr Gly Lys Cys Leu Arg Thr Leu Val Gly His Thr Gly 
     290                295                300
Gly Val Trp Ser Ser Gln Met Arg Asp Asn Ile Ile Ile Ser Gly Ser 
 305                310                315                320
Thr Asp Arg Thr Leu Lys Val Trp Asn Ala Glu Thr Gly Glu Cys Ile 
                 325                330                335
His Thr Leu Tyr Gly His Thr Ser Thr Val Arg Cys Met His Leu His 
             340                345                350
Glu Lys Arg Val Val Ser Gly Ser Arg Asp Ala Thr Leu Arg Val Trp 
         355                360                365
Asp Ile Glu Thr Gly Gln Cys Leu His Val Leu Met Gly His Val Ala 
     370                375                380
Ala Val Arg Cys Val Gln Tyr Asp Gly Arg Arg Val Val Ser Gly Ala 
 385                390                395                400
Tyr Asp Phe Met Val Lys Val Trp Asp Pro Glu Thr Glu Thr Cys Leu 
                 405                410                415
His Thr Leu Gln Gly His Thr Asn Arg Val Tyr Ser Leu Gln Phe Asp 
             420                425                430
Gly Ile His Val Val Ser Gly Ser Leu Asp Thr Ser Ile Arg Val Trp 
         435                440                445
Asp Val Glu Thr Gly Asn Cys Ile His Thr Leu Thr Gly His Gln Ser 
     450                455                460
Leu Thr Ser Gly Met Glu Leu Lys Asp Asn Ile Leu Val Ser Gly Asn 
 465                470                475                480
Ala Asp Ser Thr Val Lys Ile Trp Asp Ile Lys Thr Gly Gln Cys Leu 
                 485                490                495
Gln Thr Leu Gln Gly Pro Asn Lys His Gln Ser Ala Val Thr Cys Leu 
             500                505                510
Gln Phe Asn Lys Asn Phe Val Ile Thr Ser Ser Asp Asp Gly Thr Val 
         515                520                525
Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe Ile Arg Asn Leu Val Thr 
     530                535                540
Leu Glu Ser Gly Gly Ser Gly Gly Val Val Trp Arg Ile Arg Ala Ser 
 545                550                555                560
Asn Thr Lys Leu Val Cys Ala Val Gly Ser Arg Asn Gly Thr Glu Glu 
                 565                570                575
Thr Lys Leu Leu Val Leu Asp Phe Asp Val Asp Met Lys Ter 
             580                585                590



<210> 333
<211> 853
<212> DNA
<213> Rattus norvegicus
<308> AB020504
<400> 333

ggccacgcg  cgactagta  ggggggggg  ggggaatga  gcggaccat  tgaccccgc  60
cgctcgctc  acgcgctgg  acgggagcg  cagccaact  cagagcgaa  tcctctcac  120
ccagtcact  agagcaatg  aactgtaac  gttgttttc  caaatactg  acgatggta  180
gactgacca  caacttcct  ttgttttgt  ttatatata  ctttaaaat  tcttgtcag  240
tttactatg  atgttcatc  attcaccaa  gccctcaaa  agaagtttc  ccacagaac  300
ggcacctca  gctctgtcc  aaggaatgt  ttttaattt  tgcccggat  aaagaaaat  360
agctttgca  acactctcg  ttctttatt  gcaggcaaa  ttcactctt  attatctga  420
acttttcca  tctcagcct  ttagaggca  agatggctc  agtttcagt  gcaaaaaag  480
ctttttttt  ttttctttc  gtaaccaaa  tagagcaaa  ttggaattc  gtctgggac  540
aaaacgtca  agcagaaaa  aaatgaaaa  aaaataatt  gctttttct  tctttcatt  600
agcagcata  ataagtttg  ccactggga  tacagtaca  gggttggga  aacgatccc  660
tatttgaag  cctacttct  gcaccagca  caagaacta  atccacctc  ggactcaca  720
aacccagga  aacttgcca  ctttgagca  catatgcat  gaagagtgt  tatagaagc  780
acagtaaat  gattaacag  ggctaatac  gtgattgat  gacattggc  atggttggc  840
aaaaaaaaa  aaa  853



<210> 334
<211> 81
<212> PRT
<213> Rattus norvegicus
<308> BAA34715
<400> 334

Met Val Arg Leu Thr Ser Asn Phe Leu Leu Phe Cys Ile Ile Tyr Ile 
  1               5                  10                  15
Phe Lys Ile Ser Cys Gln Phe Tyr Tyr Val Cys Ser Ser Ile His Gln 
             20                  25                  30
Ser Pro Gln Lys Glu Val Ser Pro Gln Asn Arg His Leu Arg Leu Cys 
         35                  40                  45
Pro Lys Glu Cys Val Leu Ile Phe Ala Arg Ile Lys Glu Asn Lys Leu 
     50                  55                  60
Cys Thr His Ser Arg Phe Phe Ile Cys Arg Gln Thr Ser Leu Phe Ile 
 65                  70                  75                  80
Ile 
                 85



<210> 335
<211> 3571
<212> DNA
<213> Homo sapiens
<308> AY008274
<400> 335

ctcagcagg  caggacatt  ggtagggga  ggttgaaag  caaaagcag  aggccttgg  60
ttctcagcc  tttaaaaac  attattaaa  atatatttt  aaaatttag  ggttagagc  120
tttagtaat  tgcctgtat  acatgtaga  agtattcgt  aaccaagag  agttttaaa  180
tgtcaaaac  gggaaaacc  actctaaac  atggcttgg  tcctgttga  cttaaaagt  240
caaaagagc  tctaccaca  caaaccgtg  tgaagatat  tagcattag  atcattgcc  300
aaggcctcc  tttttgtcg  agacggatg  aaagaaagt  ggaccatgg  tctgaggtc  360
gctcttttt  tttgggaaa  aaaccatgc  aagtctcag  atatacaag  accactggg  420
ttgtaccat  ttcagcaac  ccaacaact  ttggggacc  cagagcagc  aatggccaa  480
ggcaacaac  acgccgaat  acatctgtc  agccaccta  aggcctcca  gaatggcta  540
aaatgtttc  gagctggag  ggaccagag  aattgcttg  tttagatga  ctcattgat  600
gttgtgaac  aacacaagt  aaacatatg  tgcaagtga  agaacccca  tttcaacga  660
acttcattt  attgctccc  aaagagttg  cactctatg  gctttcatt  ctggaaccc  720
aagacctgc  acaagcagc  cagacatgt  gctactgga  aattttggc  gaagacaac  780
ttctctgga  agagaaatg  aaagaagag  ggattgatg  accattgca  atcaagaga  840
gaaaagtaa  aaaaccagg  ttcatacac  gtccatgga  aagtgcata  atcagacag  900
acagaattg  tactaactg  aggcgagga  aactcaaat  tcctaaggt  ctgaaagga  960
atgatgatc  tgtgatcac  tgcttacag  tttgtggta  ccgaatagt  agtggttct  1020
atgacaaca  tttaaaagt  tggtcagca  tcacaggca  atgtctgag  acattagtg  1080
gacatacag  tggagtatg  tcatcacaa  tgagagaca  catcatcat  agtggatct  1140
cagatcgga  actcaaagt  tggaatgca  agactggag  atgtataca  accttatat  1200
ggcatactt  cactgtgcg  tgtatgcat  ttcatgaaa  aagagttgt  agcggttct  1260
gagatgcca  tcttagggt  tgggatatt  agacaggcc  gtgtttaca  gttttgatg  1320
gtcatgttg  agcagtccg  tgtgttcaa  atgatggca  gagggttgt  agtggagca  1380
atgatttta  ggtaaaggt  tgggatcca  agactgaaa  ctgtctaca  acgttgcag  1440
ggcatacta  tagagtcta  tcattacag  ttgatggta  ccatgtggt  agtggatct  1500
ttgatacat  aatccgtgt  tgggatgtg  agacaggga  ttgcattca  acgttaaca  1560
ggcaccagt  gttaacaag  ggaatggaa  tcaaagaca  tattcttgt  tctgggaat  1620
cagattcta  agttaaaat  tgggatatc  aaacaggac  gtgtttaca  acattgcaa  1680
gtcccaaca  gcatcagag  gctgtgacc  gtttacagt  caacaagaa  tttgtaatt  1740
ccagctcag  tgatggaac  gtaaaacta  gggacttga  aacgggtga  tttattcga  1800
acctagtca  attggagag  ggggggagt  ggggagttg  gtggcggat  agagcctca  1860
acacaaagc  ggtgtgtgc  gttgggagt  ggaatggga  tgaagaaac  aagctgctg  1920
tgctggact  tgatgtgga  atgaagtga  gagcagaaa  gatgaattt  tccaattgt  1980
tagacgata  actccctgc  cttccccct  caaaaagaa  aaaagaaaa  aaaaagaaa  2040
aaatccctt  ttctcagtg  tgcaggatg  tggcttggg  caacagatt  aaaagacct  2100
cagactaag  aggaaaaga  gaagagatg  caaaccata  ctgacaaga  aggcgtctg  2160
tgtctcatc  cataaaagg  ttcactttt  actgagggc  gctttgcaa  atgagactt  2220
ctaaatcaa  ccaggtgca  ttatttctt  attttcttc  ccagtggtc  ttggggcag  2280
gttaatgct  aaacatcat  acagattct  ctagcctgt  cttttacca  tgacagcta  2340
acacctaga  aggaactgc  ataatatca  aacaagtac  ggttgactt  ctaattaga  2400
agcatctgc  acaaaaagt  atttttctg  agtggaaaa  cttaaaaaa  ttactgtga  2460
ttgtttttg  acagttatc  tgaaaagct  tttttttta  tttttngcc  accattgcc  2520
atgtcaatc  atcacagta  tagcctctg  taatctatt  actgttgct  ccatataca  2580
tcttcaatg  atatgttgc  caaaggtgg  aagttgtcc  gggttctgt  agtcctgag  2640
tggatttaa  tcttgatgc  ggtgctaga  gtaggtctt  aaatatggg  ttgttgtcc  2700
aaccctgta  tgtactccc  gtggccaaa  ttatttatg  tgctaaatg  aagaaagaa  2760
aaagcaaat  atttttttt  ttttttttc  gctgtgacg  tttagtccc  gactgaatt  2820
caaatttgc  ctagtttgg  tatggaaaa  agacttttt  ccactgaaa  ttgagccat  2880
tgtgcctct  agaggctga  aatggaaga  tttcagata  taaagagtg  agtttgcct  2940
caagtaaag  attgagagt  tgtgcaaag  ttattttct  ttatctggg  aaaaattaa  3000
acacattcc  tggaacaga  ctattactt  cctgttctg  ggagaaact  ttctttttg  3060
gggctgtgg  gaatggatg  acgtacatc  taaaactga  aaaatattt  aaaaatata  3120
aaaacacaa  attaaaata  agttgctgg  cagtcttag  gttttacag  atttgggaa  3180
acaactgtt  cagttttat  gctctgagt  actgacaaa  cagaaacta  tcagttttt  3240
tagtaaagg  gtcacatgc  aacaaacaa  atgaatgaa  cagtcaaat  gtttgcctc  3300
ttctccaag  gccacaact  aagctgaac  gtgaaagtg  tttaacact  tatcctagg  3360
gatcttttt  cctccttct  tttattttt  tgnttgttt  atttatagt  tgatttaaa  3420
caatcagat  caagttggt  aattttagt  atgtaacaa  ctgacatga  ggaggaaaa  3480
aacctttaa  gggattgtg  ctatggttt  attcactta  aaattttat  ttcttataa  3540
ttaagtgca  taaaatgtg  tttttcatg  t  3571



<210> 336
<211> 590
<212> PRT
<213> Homo sapiens
<308> AY008274
<400> 336

Met Ser Lys Pro Gly Lys Pro Thr Leu Asn His Gly Leu Val Pro Val 
  1               5                  10                  15
Asp Leu Lys Ser Ala Lys Glu Pro Leu Pro His Gln Thr Val Met Lys 
             20                  25                  30
Ile Phe Ser Ile Ser Ile Ile Ala Gln Gly Leu Pro Phe Cys Arg Arg 
         35                  40                  45
Arg Met Lys Arg Lys Leu Asp His Gly Ser Glu Val Arg Ser Phe Ser 
     50                  55                  60
Leu Gly Lys Lys Pro Cys Lys Val Ser Glu Tyr Thr Ser Thr Thr Gly 
 65                  70                  75                  80
Leu Val Pro Cys Ser Ala Thr Pro Thr Thr Phe Gly Asp Leu Arg Ala 
                 85                  90                  95
Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg Ile Thr Ser Val Gln Pro 
             100                105                110
Pro Thr Gly Leu Gln Glu Trp Leu Lys Met Phe Gln Ser Trp Ser Gly 
         115                120                125
Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu Ile Asp Ser Cys Glu Pro 
     130                135                140
Thr Gln Val Lys His Met Met Gln Val Ile Glu Pro Gln Phe Gln Arg 
 145                150                155                160
Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu Ala Leu Tyr Val Leu Ser 
                 165                170                175
Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala Ala Gln Thr Cys Arg Tyr 
             180                185                190
Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu Trp Arg Glu Lys Cys Lys 
         195                200                205
Glu Glu Gly Ile Asp Glu Pro Leu His Ile Lys Arg Arg Lys Val Ile 
     210                215                220
Lys Pro Gly Phe Ile His Ser Pro Trp Lys Ser Ala Tyr Ile Arg Gln 
 225                230                235                240
His Arg Ile Asp Thr Asn Trp Arg Arg Gly Glu Leu Lys Ser Pro Lys 
                 245                250                255
Val Leu Lys Gly His Asp Asp His Val Ile Thr Cys Leu Gln Phe Cys 
             260                265                270
Gly Asn Arg Ile Val Ser Gly Ser Asp Asp Asn Thr Leu Lys Val Trp 
         275                280                285
Ser Ala Val Thr Gly Lys Cys Leu Arg Thr Leu Val Gly His Thr Gly 
     290                295                300
Gly Val Trp Ser Ser Gln Met Arg Asp Asn Ile Ile Ile Ser Gly Ser 
 305                310                315                320
Thr Asp Arg Thr Leu Lys Val Trp Asn Ala Glu Thr Gly Glu Cys Ile 
                 325                330                335
His Thr Leu Tyr Gly His Thr Ser Thr Val Arg Cys Met His Leu His 
             340                345                350
Glu Lys Arg Val Val Ser Gly Ser Arg Asp Ala Thr Leu Arg Val Trp 
         355                360                365
Asp Ile Glu Thr Gly Gln Cys Leu His Val Leu Met Gly His Val Ala 
     370                375                380
Ala Val Arg Cys Val Gln Tyr Asp Gly Arg Arg Val Val Ser Gly Ala 
 385                390                395                400
Tyr Asp Phe Met Val Lys Val Trp Asp Pro Glu Thr Glu Thr Cys Leu 
                 405                410                415
His Thr Leu Gln Gly His Thr Asn Arg Val Tyr Ser Leu Gln Phe Asp 
             420                425                430
Gly Ile His Val Val Ser Gly Ser Leu Asp Thr Ser Ile Arg Val Trp 
         435                440                445
Asp Val Glu Thr Gly Asn Cys Ile His Thr Leu Thr Gly His Gln Ser 
     450                455                460
Leu Thr Ser Gly Met Glu Leu Lys Asp Asn Ile Leu Val Ser Gly Asn 
 465                470                475                480
Ala Asp Ser Thr Val Lys Ile Trp Asp Ile Lys Thr Gly Gln Cys Leu 
                 485                490                495
Gln Thr Leu Gln Gly Pro Asn Lys His Gln Ser Ala Val Thr Cys Leu 
             500                505                510
Gln Phe Asn Lys Asn Phe Val Ile Thr Ser Ser Asp Asp Gly Thr Val 
         515                520                525
Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe Ile Arg Asn Leu Val Thr 
     530                535                540
Leu Glu Ser Gly Gly Ser Gly Gly Val Val Trp Arg Ile Arg Ala Ser 
 545                550                555                560
Asn Thr Lys Leu Val Cys Ala Val Gly Ser Arg Asn Gly Thr Glu Glu 
                 565                570                575
Thr Lys Leu Leu Val Leu Asp Phe Asp Val Asp Met Lys Ter 
             580                585                590



<210> 337
<211> 696
<212> DNA
<213> Rattus norvegicus
<308> AB022014
<400> 337

atggagggg  gtgtgtcta  cctaatggt  tgtaacctg  cctacaacg  gaagctgga  60
gagttgaag  aaagcattt  ggctgataa  tctctggcc  ctagaactg  tcaggacag  120
agaacagca  tgcactggg  atgctcagc  ggtcataca  aaattgttg  attcttgct  180
caacttgga  tgccagtaa  tgaaaaaga  gatgcaggt  ggtctcctc  tcatattgc  240
gcttccgct  gccgggatg  gattgtaaa  gcccttctg  taaaagggg  acaagtgaa  300
gccgtcaat  agaatggct  cacggccct  cattatgca  cttccaaga  taggcatga  360
attgctgtt  tgttactag  aggtggggc  aatccagat  ctaagaacc  ttatgatgc  420
acagcaatg  accgggcag  agccaaggg  aacttgaag  tggttcata  ccttctgtt  480
tacaaagca  ccacaaaca  ccaagatac  gagggtaac  ctcctctac  cttagcctg  540
gatgaggag  gagtggaag  agcaaaatt  ctggtgacc  aaggagcaa  tatttacat  600
gaaaataag  aagaaaaga  accgctgca  gtcgccaaa  ggggcctgg  tttaatact  660
aaaagaatc  cagaaagtg  agaggcttc  atgtag  696



<210> 338
<211> 231
<212> PRT
<213> Rattus norvegicus
<308> Q9Z2X3
<400> 338

Met Glu Gly Cys Val Ser Asn Leu Met Val Cys Asn Leu Ala Tyr Asn 
  1               5                  10                  15
Gly Lys Leu Asp Glu Leu Lys Glu Ser Ile Leu Ala Asp Lys Ser Leu 
             20                  25                  30
Ala Thr Arg Thr Asp Gln Asp Ser Arg Thr Ala Leu His Trp Ala Cys 
         35                  40                  45
Ser Ala Gly His Thr Glu Ile Val Glu Phe Leu Leu Gln Leu Gly Val 
     50                  55                  60
Pro Val Asn Glu Lys Asp Asp Ala Gly Trp Ser Pro Leu His Ile Ala 
 65                  70                  75                  80
Ala Ser Ala Gly Arg Asp Glu Ile Val Lys Ala Leu Leu Ile Lys Gly 
                 85                  90                  95
Ala Gln Val Asn Ala Val Asn Gln Asn Gly Cys Thr Ala Leu His Tyr 
             100                105                110
Ala Ala Ser Lys Asn Arg His Glu Ile Ala Val Met Leu Leu Glu Gly 
         115                120                125
Gly Ala Asn Pro Asp Ala Lys Asn His Tyr Asp Ala Thr Ala Met His 
     130                135                140
Arg Ala Ala Ala Lys Gly Asn Leu Lys Met Val His Ile Leu Leu Phe 
 145                150                155                160
Tyr Lys Ala Ser Thr Asn Ile Gln Asp Thr Glu Gly Asn Thr Pro Leu 
                 165                170                175
His Leu Ala Cys Asp Glu Glu Arg Val Glu Glu Ala Lys Leu Leu Val 
             180                185                190
Thr Gln Gly Ala Ser Ile Tyr Ile Glu Asn Lys Glu Glu Lys Thr Pro 
         195                200                205
Leu Gln Val Ala Lys Gly Gly Leu Gly Leu Ile Leu Lys Arg Ile Ala 
     210                215                220
Glu Ser Glu Glu Ala Ser Met 
 225                230



<210> 339
<211> 1468
<212> DNA
<213> Homo sapiens
<308> AB009619
<400> 339

aagtagttg  tgggacagc  aaatggagg  gtgtgtgtc  aacctaatg  tctgcaacc  60
ggcctacag  gggaagctg  aagagttga  ggagagtat  ctggccgat  aatccctgg  120
tactagaac  gaccaggac  gcagaactg  attgcactg  gcatgctca  ctggacata  180
agaaattgt  gaatttttg  tgcaacttg  agtgccagt  aatgataaa  acgatgcag  240
ttggtctcc  cttcatatt  cggcttctg  tggccggga  gagattgta  aagcccttc  300
gggaaaagg  gctcaagtg  atgctgtca  tcaaaatgg  tgtactccc  tacattatg  360
agcttcgaa  aacaggcat  agatcgctg  catgttact  gaaggcggg  ctaatccag  420
tgctaagga  cattatgag  ctacagcaa  gcaccgggc  gcagccaag  gtaacttga  480
gatgattca  atccttctg  actacaaag  atccacaaa  atccaagac  ctgagggta  540
cactcctct  cacttagcc  gtgatgagg  gagagtgga  gaagcaaaa  tgctggtgt  600
ccaaggagc  agtatttac  ttgagaata  agaagaaaa  acacccctg  aagtggcca  660
aggtggcct  ggtttaata  tcaagagaa  ggtggaagg  taaacagct  ggatttatt  720
ttactttgt  tgttgtgtt  ttgtcccca  tgtcctaca  actaatgta  ttgtgcaca  780
gacatcatc  atgaatgat  aagttttct  accttcaaa  tcttataaa  atgttgact  840
ttgttcctg  tgagttact  gttcgaagc  tacagcttg  tttccaggc  tcgaataac  900
gttgagatt  ttctactgt  gtcgtatat  cttctatat  gaattctgg  taatttgga  960
taactaatt  tgtggctgt  gtgagtctt  agcaccctc  catgtacct  atatccctc  1020
ctgaaacag  acagctcca  tagcaacaa  ctagttgtt  tgccagatg  ttctatgtg  1080
attctgtaa  gttcctcca  acagttaaa  catcctaac  tgtttttca  gctcactca  1140
gcctacgcc  aacgtttct  tttttttta  ccatgaggt  taatttatt  ttgtgatag  1200
agggatatt  acatatttt  gtggaccac  ttttaagtt  gatggtgtg  tctaaaata  1260
tgaaaaaca  tagcccata  acctatgta  ttgtttttg  tgggttgtt  actctgaaa  1320
aaaatgtat  gttttctta  aaggaagtt  taaagtacc  attttgtgt  atcctgtat  1380
gaaaagaat  tcaagcttg  taaaatgac  tgtaacaaa  atgtatttt  atttgtatt  1440
cagaaacta  aaaataaaa  gttgaaag  1468



<210> 340
<211> 226
<212> PRT
<213> Homo sapiens
<308> O75832
<400> 340

Met Glu Gly Cys Val Ser Asn Leu Met Val Cys Asn Leu Ala Tyr Ser 
  1               5                  10                  15
Gly Lys Leu Glu Glu Leu Lys Glu Ser Ile Leu Ala Asp Lys Ser Leu 
             20                  25                  30
Ala Thr Arg Thr Asp Gln Asp Ser Arg Thr Ala Leu His Trp Ala Cys 
         35                  40                  45
Ser Ala Gly His Thr Glu Ile Val Glu Phe Leu Leu Gln Leu Gly Val 
     50                  55                  60
Pro Val Asn Asp Lys Asp Asp Ala Gly Trp Ser Pro Leu His Ile Ala 
 65                  70                  75                  80
Ala Ser Ala Gly Arg Asp Glu Ile Val Lys Ala Leu Leu Gly Lys Gly 
                 85                  90                  95
Ala Gln Val Asn Ala Val Asn Gln Asn Gly Cys Thr Pro Leu His Tyr 
             100                105                110
Ala Ala Ser Lys Asn Arg His Glu Ile Ala Val Met Leu Leu Glu Gly 
         115                120                125
Gly Ala Asn Pro Asp Ala Lys Asp His Tyr Glu Ala Thr Ala Met His 
     130                135                140
Arg Ala Ala Ala Lys Gly Asn Leu Lys Met Ile His Ile Leu Leu Tyr 
 145                150                155                160
Tyr Lys Ala Ser Thr Asn Ile Gln Asp Thr Glu Gly Asn Thr Pro Leu 
                 165                170                175
His Leu Ala Cys Asp Glu Glu Arg Val Glu Glu Ala Lys Leu Leu Val 
             180                185                190
Ser Gln Gly Ala Ser Ile Tyr Ile Glu Asn Lys Glu Glu Lys Thr Pro 
         195                200                205
Leu Gln Val Ala Lys Gly Gly Leu Gly Leu Ile Leu Lys Arg Met Val 
     210                215                220
Glu Gly 
 225



<210> 341
<211> 5350
<212> DNA
<213> Rattus norvegicus
<308> AF000114
<400> 341

gggtaggag  aagggaagg  tgggtaagg  cggaaaaag  agcatcggt  agccgcgaa  60
cccaggaga  aasstgggg  cctgagcca  aaccggagc  ctagcggca  aagscagac  120
cccagggtt  gtcanctcc  catgatgag  ctccggctt  tcagcattc  gctcgccgc  180
gtggtctct  gagcccagg  ctggggcta  tatggctgc  atgaggagc  ggtggggcc  240
ctgtatgca  ggtctctgg  tgcttcctc  tactatgga  tctttacca  agcccgctt  300
gcccggcta  acggcatca  tggatggtc  ccccggatt  gggacccga  tccctggct  360
cagatagac  taatgaaga  gcatcgaat  cgggctgtg  ccacacagg  agcctttaa  420
tcttgggat  gggtcacac  ttacatgct  ctctacggg  accgtgtgg  cagctggac  480
ccattctac  aacaagggc  caacgcgac  ttcttcggt  atgtcaacg  ctcggcggt  540
gtacgccat  acctgcact  ccattttac  gctcgctac  tccgcatcg  gccactggc  600
tggaacccc  gcggcaaga  tggcttgag  ctgggcatc  acggttgtc  ctacacgtc  660
aacatcctg  attttgacg  cgatgatgc  atttcatac  gcttccagc  aggggccag  720
caaagtctt  gggacgtgt  cgcttttag  ttcaagaca  aggagaagg  cgggctgct  780
ttgcacacc  aaggctccc  gggggatta  gtgacgctt  aactgcaag  agcacacct  840
ctgctgcac  tgagcctgg  cagcagccc  atccagccg  gacctggtc  caccacggt  900
agcgctggt  gcgtactta  tgacctaag  tggcattat  tgcgggtgg  ccgatacgg  960
cgagaagca  atctcaccc  ggatggtta  gtacatcgc  ttgtgctca  cggcgactt  1020
gaaaggctg  atctcgaaa  tgagatatt  atcggaggt  tagtgggcg  agcgcgtaa  1080
aacctggcc  accgccata  cttccgtgg  tgtatagaa  acgtgatct  caaccggat  1140
aacatagct  aaatggcag  gcagcgcca  tcgcggatc  ccttcgagg  taatgtggc  1200
ttccggtgc  tggatcccg  tccacaccc  atcaacttc  gaggccctc  caacttcgt  1260
caagtgcct  gctttccac  tcgaggccg  cttgctgtc  ccttccgct  ccgcacctg  1320
gacctcaca  ggctgctcc  tttctcccg  ttgggggat  ggctgggtc  tgtggagct  1380
atgcttagt  aagggcaag  caatgtatc  atcgcgcag  ctggccgca  gaagcttca  1440
tttgctgcg  ggtaccgcc  gaatgatgg  ttctggcat  aggtgaact  tgtggcaca  1500
gaaaaccat  cggtcatca  tattgatga  gtggagggg  cagaggtca  ggtatcata  1560
ccactgctg  tccgcacag  gacttcata  ttctttggt  gttgtccca  accagccag  1620
cgatggggc  gccactcca  ccagacagc  ttccatggc  gcatggagc  gctcaaggt  1680
gatggtcaa  tggtcaacc  cactctggt  gagtttcgg  agcttggtt  ctttgctga  1740
gtcctcttt  acacatgtg  catcacaga  agatgcagc  ctaatatgt  tgagcatga  1800
gggcgctgc  accagtctt  ggatgactt  atctgctac  gcgaactca  cggctacaa  1860
ggagttacc  gccatgaac  attgtataa  gagtcctgt  aagcctatc  cctcagcgg  1920
aaatattct  gaaattaca  cattgatcc  gatggcagt  gacccctga  accatttgt  1980
gtgtattgt  atatccgag  gaaccgagc  tggacagtt  tgcgacatg  caggctatg  2040
accactcga  tgacaggtt  cagcatgga  cggcccttt  tgggggcca  ccaatactg  2100
aatgcctcc  gggaggaag  cagtgctct  gccaatgct  cccagcact  tgagcagtg  2160
atcgagttc  cctgctaca  ttcccggct  ctcaacact  caggaggct  cccctacag  2220
ttttggatt  gccgaaatg  agaacagca  ttctactgg  gaggctccc  gcctgggat  2280
caacgctgt  cctgtgggc  ggaccagag  tgtatagac  ctgcactgc  ctgcaactg  2340
gatgctgac  agccacagt  gagaacaga  aaggggctc  tgacctttg  ggaccatct  2400
cctgtcact  aggtagtga  aggtgacac  aaccgctcc  gctctgaag  tcagttctt  2460
ctgaggcct  tgcgctgtt  tggtgaccg  aattcctgg  acactatct  cttccgcac  2520
ggagctgca  tgcgtttcc  tccaatccg  gccaaccac  gccttgatg  ctccttcta  2580
ttcaggacc  cggctccct  aggagtctt  ctagagaac  tggggggtc  tttctgcca  2640
tggcgccga  cttacgtga  agtggagct  aacacatcc  gggatgtgg  ctttgcctt  2700
gatattggc  atggggatg  gaacctgac  gtgcactca  atgacttcg  gttcaatga  2760
gacgagtgg  atttggtcc  ggctgaaat  aacgtgaag  aggcccggc  gcgagtgga  2820
catcggccc  gggtgctaa  gcccatgcc  ctgcagacg  acatctggc  ggagtatga  2880
caacccctc  atgtgggat  tgcagagct  aagaggcgc  catttgtgg  gtgcttgag  2940
gccatgcgt  tgaatggag  gactctgaa  ttggagggt  gtgccaatg  ctccgaggg  3000
accttcccc  actgcacgg  ccactgcac  cacccccgg  tcccctgtt  ccacggagg  3060
cgctgtgtg  agcgataca  ctactacac  tgtgactgt  acctcacag  ttttgatgg  3120
ccatattgt  atcacgata  tggtggatt  tttgagact  gcacatgga  gcgctataa  3180
ctccagtca  cactgcgtt  tgcggccca  gagttctct  acatgctga  ccggccggt  3240
ccgggctat  agcctggct  tatcccagg  tacgacact  ctggttacg  gcctgggta  3300
catggtcct  ggtaccgcc  acccgacta  ccaaggcct  gccggccag  gcccggata  3360
cggggnccc  tgtacaatg  tactggaga  gaggtctcc  ttagcttca  caccagctc  3420
gctcctgca  tcctgctct  cgtcagctc  tttgtgcgt  actacatgg  cgtgctcat  3480
aaggaagat  ggaccctac  gcttcgcta  cagctgggc  ccagtccct  tgtgtacca  3540
ctaaccacc  ggccagtga  cgatggcca  ccccatagt  tcaacatca  ccgggtcta  3600
cgaaacctc  ttatccagg  ggactactt  ccgctgaca  aacagaagt  ctctctcct  3660
gtggacagc  agctggact  ccccaaggc  ttgtatcta  ggcgtgtga  ggagacagg  3720
gtcattgac  cagagattc  gcggtacaa  accccaggt  tctcaggct  cctgtctgg  3780
gtccggttc  acaatgtgg  tcctctcaa  acccatttc  gaacccctc  ccccatgac  3840
gctgagctg  cggaggcca  gcgggttca  ggagaactg  cggagtcta  ctgtggcgc  3900
atgccacgc  ttgtctccg  ggtgccacc  gagcttgat  cctggtacc  gcccccaga  3960
ttcccatac  accatgacg  cggatggat  gccatactc  taggttttt  ggtggcctt  4020
ctgctgctg  ggcttgtgg  aatgctggt  ctgttctat  tgcaaaatc  tcgatacaa  4080
ggctcctat  acaccaacg  gcccaaggc  acccatgat  cccaccctg  cggcaaagc  4140
cccctacct  cctcaggcc  tgcccaggc  cctgccccc  ctccagctc  cacccaggt  4200
ccgacccca  ccccagccc  agcctctgg  ccaggcccc  gggaccaga  cctccccca  4260
atcttggag  agtccaggt  tgaatgagt  acaagggct  cagggacca  ggccaactc  4320
tctaagtyc  ttmagctcc  gcctctcct  tcccctgtc  gggacattt  gctcttctt  4380
gcaggctct  ttcaccagg  ggatcccct  ttgccaagt  tggtgtgca  agctacaga  4440
gggaccaaa  ggagtggcc  agtctcact  cctaaacca  tgccctgcc  ccacccccc  4500
ccccagctc  tggctgttt  cctgcccta  gggagaaag  tcatggagc  gaggcgggc  4560
tttcctgcc  tctctgtcc  agctgctgg  aaggattaa  aaccaaggg  aggggagat  4620
aactgcctc  cttcctgtg  gtattatca  cagggacag  tgtggggga  cgaggggct  4680
cacagggca  gcagggagg  agggaggag  ctgctaaaa  acaccctgg  gcctccccc  4740
tgccctrct  accggctgt  ttccatctr  ttcctctca  ctggggttg  gggaagaac  4800
tcatcccca  cccccacct  acccaaccc  ttttgttct  acagagacc  agaggcctc  4860
gcttagtca  tttagtacc  ccactgctt  acatgcttt  gccaaagcc  taaaaagcc  4920
gcaagtaga  gaaataatg  agaccctgc  cagccagtc  tctgctcct  caccccttt  4980
caaaatacg  aatagcctg  gtgcctgtg  gcaggcctg  cccccctcc  tgcatgagg  5040
gccccccct  ccccgctca  agatgctgc  tgttcgtcc  ggaggtcat  ttctttata  5100
atatttttt  ttgcaaagc  tctctctag  gaactatat  ttactctaa  tttttaatt  5160
tctgtttat  tataaaaga  ctcagtggg  cgtcctgtg  tgtgcccag  ttgtagtga  5220
ctccttctg  gttggatgt  tcatgagtc  tgccagcca  tcacccgcc  gccgggcct  5280
cattctaga  cagggcaga  cccgctgtg  cctcacctg  gcaggttca  taaaagcag  5340
gtggcagaaa  5350



<210> 342
<211> 1381
<212> PRT
<213> Rattus norvegicus
<308> P97846
<400> 342

Met Met Ser Leu Arg Leu Phe Ser Ile Leu Leu Ala Ala Val Val Ser 
  1               5                  10                  15
Gly Ala Gln Gly Trp Gly Tyr Tyr Gly Cys Asn Glu Glu Leu Val Gly 
             20                  25                  30
Pro Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Gly Leu Phe 
         35                  40                  45
Thr Thr Ala Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro 
     50                  55                  60
Arg Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys 
 65                  70                  75                  80
His Arg Ile Arg Ala Val Ala Thr Gln Gly Ala Phe Asn Ser Trp Asp 
                 85                  90                  95
Trp Val Thr Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp 
             100                105                110
Thr Pro Phe Tyr Gln Gln Gly His Asn Ala Thr Phe Phe Gly Asn Val 
         115                120                125
Asn Asp Ser Ala Val Val Arg His Asp Leu His Tyr His Phe Thr Ala 
     130                135                140
Arg Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile 
 145                150                155                160
Gly Leu Arg Leu Gly Ile Tyr Gly Cys Pro Tyr Thr Ser Asn Ile Leu 
                 165                170                175
Tyr Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Gln Arg Gly Ala 
             180                185                190
Ser Gln Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Thr Glu Glu 
         195                200                205
Lys Asp Gly Leu Leu Leu His Thr Glu Gly Ser Gln Gly Asp Tyr Val 
     210                215                220
Thr Leu Glu Leu Gln Gly Ala His Leu Leu Leu His Met Ser Leu Gly 
 225                230                235                240
Ser Ser Pro Ile Gln Pro Arg Pro Gly His Thr Thr Val Ser Ala Gly 
                 245                250                255
Gly Val Leu Asn Asp Leu Ser Trp His Tyr Val Arg Val Asp Arg Tyr 
             260                265                270
Gly Arg Glu Ala Asn Leu Thr Leu Asp Gly Tyr Val His Arg Phe Val 
         275                280                285
Leu Asn Gly Asp Phe Glu Arg Leu Asn Leu Glu Asn Glu Ile Phe Ile 
     290                295                300
Gly Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn 
 305                310                315                320
Phe Arg Gly Cys Ile Glu Asn Val Ile Tyr Asn Arg Ile Asn Ile Ala 
                 325                330                335
Glu Met Ala Val Gln Arg His Ser Arg Ile Thr Phe Glu Gly Asn Val 
             340                345                350
Ala Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly 
         355                360                365
Pro His Asn Phe Val Gln Val Pro Gly Phe Pro Arg Arg Gly Arg Leu 
     370                375                380
Ala Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr Gly Leu Leu Leu 
 385                390                395                400
Phe Ser Arg Leu Gly Asp Gly Leu Gly His Val Glu Leu Met Leu Ser 
                 405                410                415
Glu Gly Gln Val Asn Val Ser Ile Ala Gln Thr Gly Arg Lys Lys Leu 
             420                425                430
Gln Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe Trp His Glu Val 
         435                440                445
Asn Phe Val Ala Gln Glu Asn His Ala Val Ile Ser Ile Asp Asp Val 
     450                455                460
Glu Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu Ile Arg Thr Gly 
 465                470                475                480
Thr Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala Ser Arg Trp Gly 
                 485                490                495
Cys His Ser Asn Gln Thr Ala Phe His Gly Cys Met Glu Leu Leu Lys 
             500                505                510
Val Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu Phe Arg Lys Leu 
         515                520                525
Gly Tyr Phe Ala Glu Val Leu Phe Asp Thr Cys Gly Ile Thr Asp Arg 
     530                535                540
Cys Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys Tyr Gln Ser Trp 
 545                550                555                560
Asp Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr Lys Gly Val Thr 
                 565                570                575
Cys His Glu Pro Leu Tyr Lys Glu Ser Cys Glu Ala Tyr Arg Leu Ser 
             580                585                590
Gly Lys Tyr Ser Gly Asn Tyr Thr Ile Asp Pro Asp Gly Ser Gly Pro 
         595                600                605
Leu Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu Asn Arg Ala Trp 
     610                615                620
Thr Val Val Arg His Asp Arg Leu Trp Thr Thr Arg Val Thr Gly Ser 
 625                630                635                640
Ser Met Asp Arg Pro Phe Leu Gly Ala Ile Gln Tyr Trp Asn Ala Ser 
                 645                650                655
Trp Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln His Cys Glu Gln 
             660                665                670
Trp Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu Asn Thr Ala Gly 
         675                680                685
Gly Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu Glu Gln His Phe 
     690                695                700
Tyr Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys Ala Cys Gly Leu 
 705                710                715                720
Asp Gln Ser Cys Ile Asp Pro Ala Leu His Cys Asn Cys Asp Ala Asp 
                 725                730                735
Gln Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr Phe Val Asp His 
             740                745                750
Leu Pro Val Thr Gln Val Val Ile Gly Asp Thr Asn Arg Ser Ser Ser 
         755                760                765
Glu Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr Gly Asp Arg Asn 
     770                775                780
Ser Trp Asn Thr Ile Ser Phe Arg Thr Gly Ala Ala Leu Arg Phe Pro 
 785                790                795                800
Pro Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe Tyr Phe Arg Thr 
                 805                810                815
Ser Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly Gly Pro Phe Cys 
             820                825                830
Gln Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn Thr Ser Arg Asp 
         835                840                845
Val Val Phe Ala Phe Asp Ile Gly Asn Gly Asp Glu Asn Leu Thr Val 
     850                855                860
His Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp His Leu Val Arg 
 865                870                875                880
Ala Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val Asp His Arg Pro 
                 885                890                895
Trp Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile Trp Leu Glu Tyr 
             900                905                910
Asp Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys Arg Arg Pro Phe 
         915                920                925
Val Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val Thr Leu Asn Leu 
     930                935                940
Glu Gly Arg Ala Asn Ala Ser Glu Gly Thr Phe Pro Asn Cys Thr Gly 
 945                950                955                960
His Cys Thr His Pro Arg Phe Pro Cys Phe His Gly Gly Arg Cys Val 
                 965                970                975
Glu Arg Tyr Ser Tyr Tyr Thr Cys Asp Cys Asp Leu Thr Ala Phe Asp 
             980                985                990
Gly Pro Tyr Cys Asn His Asp Ile Gly Gly Phe Phe Glu Thr Gly Thr 
         995                1000                1005
Trp Met Arg Tyr Asn Leu Gln Ser Ala Leu Arg Ser Ala Ala Gln Glu 
     1010                1015                1020
Phe Ser His Met Leu Ser Arg Pro Val Pro Gly Tyr Glu Pro Gly Tyr 
 1025                1030                1035                1040
Ile Pro Gly Tyr Asp Thr Pro Gly Tyr Val Pro Gly Tyr His Gly Pro 
                 1045                1050                1055
Gly Tyr Arg Leu Pro Asp Tyr Pro Arg Pro Gly Arg Pro Val Pro Gly 
             1060                1065                1070
Tyr Arg Gly Pro Val Tyr Asn Val Thr Gly Glu Glu Val Ser Phe Ser 
         1075                1080                1085
Phe Ser Thr Ser Ser Ala Pro Ala Val Leu Leu Tyr Val Ser Ser Phe 
     1090                1095                1100
Val Arg Asp Tyr Met Ala Val Leu Ile Lys Glu Asp Gly Thr Leu Gln 
 1105                1110                1115                1120
Leu Arg Tyr Gln Leu Gly Thr Ser Pro Tyr Val Tyr Gln Leu Thr Thr 
                 1125                1130                1135
Arg Pro Val Thr Asp Gly Gln Pro His Ser Val Asn Ile Thr Arg Val 
             1140                1145                1150
Tyr Arg Asn Leu Phe Ile Gln Val Asp Tyr Phe Pro Leu Thr Glu Gln 
         1155                1160                1165
Lys Phe Ser Leu Leu Val Asp Ser Gln Leu Asp Ser Pro Lys Ala Leu 
     1170                1175                1180
Tyr Leu Gly Arg Val Met Glu Thr Gly Val Ile Asp Pro Glu Ile Gln 
 1185                1190                1195                1200
Arg Tyr Asn Thr Pro Gly Phe Ser Gly Cys Leu Ser Gly Val Arg Phe 
                 1205                1210                1215
Asn Asn Val Ala Pro Leu Lys Thr His Phe Arg Thr Pro Arg Pro Met 
             1220                1225                1230
Thr Ala Glu Leu Ala Glu Ala Met Arg Val Gln Gly Glu Leu Ser Glu 
         1235                1240                1245
Ser Asn Cys Gly Ala Met Pro Arg Leu Val Ser Glu Val Pro Pro Glu 
     1250                1255                1260
Leu Asp Pro Trp Tyr Leu Pro Pro Asp Phe Pro Tyr Tyr His Asp Asp 
 1265                1270                1275                1280
Gly Trp Ile Ala Ile Leu Leu Gly Phe Leu Val Ala Phe Leu Leu Leu 
                 1285                1290                1295
Gly Leu Val Gly Met Leu Val Leu Phe Tyr Leu Gln Asn His Arg Tyr 
             1300                1305                1310
Lys Gly Ser Tyr His Thr Asn Glu Pro Lys Ala Thr His Asp Ser His 
         1315                1320                1325
Pro Gly Gly Lys Ala Pro Leu Pro Pro Ser Gly Pro Ala Gln Ala Pro 
     1330                1335                1340
Ala Pro Thr Pro Ala Pro Thr Gln Val Pro Thr Pro Ala Pro Ala Pro 
 1345                1350                1355                1360
Ala Ser Gly Pro Gly Pro Arg Asp Gln Asn Leu Pro Gln Ile Leu Glu 
                 1365                1370                1375
Glu Ser Arg Ser Glu 
             1380



<210> 343
<211> 5293
<212> DNA
<213> Homo sapiens
<308> U87223
<400> 343

caagagcgg  ggaccagga  ccagagaga  agagagaga  aagagagag  agagacaga  60
cgcttgggg  cgaaaggag  gagggaggg  agggtgggt  aggaggaga  agcggtctg  120
tgcaaaccc  aggaggaga  cttggagcc  aagccagaa  tcgagccct  gccggagcc  180
ttcacaggg  ggcggctgc  gggaccgtc  gccctgcat  atgcatctc  ggctcttct  240
catcctgct  gccgcggtc  caggagccg  gggctgggg  tactacggc  gcgacgagg  300
gctggtggg  cccctgtat  cacgctccc  gggcgcctc  tcctactac  gtctcctta  360
tgcgccgcg  ttcgccagg  tgcacggca  aagcgggtg  tcaccacgg  ttggggatc  420
gaatccctg  ctccagata  acttaatga  gaagcaccg  atccgggcc  tggccacac  480
gggctcctt  aattcttgg  actgggtca  acgttacat  ctactctac  gcgaccgag  540
ggacagctg  acaccgttc  accagcgag  gcacaactc  accttcttt  gtaacgtga  600
cgagtcggc  gtggtgcgc  atgacctgc  cttccactt  actgcgcgc  acatccgca  660
cgtgcccct  gcctggaac  cacgcggca  gatcggcct  aggctcggc  tctatggct  720
cccatacaa  gccgacata  tctatttcg  cggcgacga  gccatctcc  accgcttcc  780
gcgaggggt  agccgaagc  tgtgggacg  gttcgcctt  agcttcaag  ccgaggaga  840
ggacggtct  ctgctgcac  ccgagggcg  ccagggcga  tacgtgacg  tcgagctgg  900
gggggcaca  ctgctgctg  acatgagcc  gggcagcag  cctatccag  caagaccag  960
tcacaccac  gtgagcgca  gcggagtcc  caatgacca  cactggcac  atgtgcggg  1020
ggaccgatt  ggccgcgat  taaatttca  cctggacgg  tatgtgcag  gctttattc  1080
caatggaga  ttcgagagg  tgaacctgg  cactgagat  ttcatcgga  gtctggtgg  1140
cgccgcgcg  aagaacctg  cctatcggc  taacttccg  ggctgcata  aaaacgtaa  1200
cttcaaccg  gtcaacatc  cagacctgg  cgtgcggcg  cattcccgg  tcaccttcg  1260
gggtaaggt  gcttttcgt  gcctggacc  ggtaccgca  cctatcaac  tcggaggcc  1320
tcacaactt  gttcaagtg  ccggtttcc  acgccgtgg  cgcctggca  tctcatttc  1380
cttccgcac  tgggacctc  ccgggcttc  ccttttctc  cgtctgggg  acgggctgg  1440
ccacgtgga  ctgacgctc  gcgaagggc  ggtcaacgt  tccatcgcg  agagcggcc  1500
aaagaagct  cagttcgct  ctgggtacc  actgaatga  ggcttttgg  acgaggtga  1560
ttttgtggc  caggaaaac  atgcagtta  cagcattga  gatgtggaa  gggcagagg  1620
cagggtctc  tacccgttg  tgatccgga  agggacctc  tatttcttt  ggggttgtc  1680
caagccagc  agtcgatgg  actgccact  caaccagac  gcattccat  gctgcatgg  1740
gctgctcaa  gtggatggt  aactggtca  cctgactct  gtggagggc  ggcggcttg  1800
attctatgc  gaggtcctc  ttgatacat  tggcatcac  gataggtgc  gccctaaca  1860
gtgtgagca  gatggacgc  gctaccagt  ttgggatga  ttcatttgc  actgcgaac  1920
gacgggcta  aagggagag  cctgccaca  acctttgta  aaggaatcc  gtgaggctt  1980
tcggctcag  gggaaaact  ctggaaact  caccattga  cctgatggc  gtggccccc  2040
gaagccatt  gtagtgtac  gtgatatcc  agagaaccg  gcgtggaca  ttgtgcggc  2100
tgacaggct  tggacaact  gagtgacag  ttccagcat  gagcggcca  tcctggggg  2160
tatccagta  tggaatgca  cctgggagg  agtcagtgc  cttgccaat  cttcccagc  2220
ttgtgaaca  tggatcgag  tctcctgct  caattcccg  ctgctcaac  ctgcaggag  2280
ctaccccta  agcttttgg  ttggccgaa  tgaggagca  cacttctac  ggggaggct  2340
ccagcctgg  atccagcgc  gtgcctgtg  tctggaccg  agctgtgtg  accctgcct  2400
gtactgcaa  tgtgacgct  accagcccc  gtggagaac  gacaaggga  tgctgacct  2460
tgtggacca  ctgcctgtc  ctcaggtag  gatagggga  acgaaccgc  ccacttctg  2520
ggcccagtt  ttcctgagg  ctctgcgct  ctatggcga  cgaaattcc  ggaacacca  2580
ttccttcca  accggggct  cactacgct  ccccccaat  cgtgccaac  acagcctgg  2640
tgtctcctt  tacttcagg  cctctgctc  ctcgggggt  ttcctagag  atatggggg  2700
cccttactg  cagtggcgc  gaccttatg  gcgggtgga  ctcaacaca  cccgggatg  2760
ggtcttcgc  tttgatgtg  ggaatgggg  tgagaacct  acagtacac  cagacgact  2820
tgagttcaa  gatgacgag  ggcacctgg  ccgggctga  atcaacgtg  agcaggccc  2880
gctccgagt  gatcaccgg  cctgggttc  gcggcctat  ccactgcag  cctacatct  2940
gatggagta  gaccagccc  tctatgtgg  atctgcaga  cttaagaga  gcccctttg  3000
gggttgctt  agggccatg  gtctgaacg  agtgactct  aacctggag  gccgtgcca  3060
tgcctctga  ggtacctca  ccaactgca  aggccactg  gcccaccct  ggctcccct  3120
tttccatgg  ggccgctgc  tggagcgct  tagctacta  acgtgtgac  gtgacctca  3180
ggcttttga  gggccatac  gcaaccacg  tattggtgg  ttctttgag  cgggcacct  3240
gatgcgcta  aacctacag  cagcgctgc  ctctgcagc  agggagttc  cccacatgc  3300
gagccggcc  gtgccaggc  atgagcctg  ctacatccc  ggctatgat  ctccgggct  3360
tgtgcctgg  taccatggc  ccgggtacc  cctgcccga  tacccccgg  ctggtcggc  3420
tgtgcccgg  taccgtggg  ctgtctaca  cgttacggg  gaggaggtc  ccttcagct  3480
cagcaccag  tccgcccct  ctgtcctgc  ctacgtcag  tcctttgtt  gtgactaca  3540
ggctgtgct  atcaaggat  atgggaccc  tcagctgcg  tatcagctg  gcaccagtc  3600
ctacgtgta  cagctaacc  ctcgaccag  gaccgatgg  cagccccat  gcatcaata  3660
cacccgtgt  taccggaac  tcttcatcc  ggtggacta  ttcccactg  cagagcaga  3720
gttctcgct  ttggtggac  gccagttgg  ctcacccaa  gccttgtat  tagggcgtg  3780
gatggagac  ggagtcatt  acccggaga  ccagcgcta  aacacccca  gtttctcag  3840
ctgcctgtc  ggtgttcga  tcaacaacg  ggctcccct  aagacccac  tccgaaccc  3900
tcgacccat  actgctgag  tagctgagg  ccttcgagt  cagggagaa  tgtccgaat  3960
taattgcgg  gctatgcca  gtcttgttt  agaggtgcc  cctgagctt  atccctggt  4020
tctgccccc  gacttcccc  actaccatg  tgaaggatg  gttgccata  ttttaggct  4080
tttggtggc  tttctgctg  tggggctgg  gggaatgtt  gtgctcttc  atctgcaaa  4140
tcatcgcta  aagggctcc  accatacca  tgagcccaa  gctgcccac  agtaccatc  4200
tggcagcaa  cctccccta  ccacttcag  ccctgccca  gtccccacc  ctacagcag  4260
tcccaacca  gctccagcc  cagccccag  cccagcccc  actccagcc  cagcccctg  4320
cccccggga  cagaaccta  cccagatcc  ggaggagtc  aggtctgaa  gagtcagaa  4380
ggcttctgg  accaattcc  gctcctgac  ttcccccag  cctgcctct  ccccatcct  4440
tcagggaca  ttggctcct  ttagctggc  ctgctcatc  agaggatat  cccccatcc  4500
ccccccatc  agtttggtg  gcagagcta  agatgggac  caagggagt  gccgagcct  4560
actgcctaa  ccaatgccc  tctcatccc  gtttcccca  gctcctggc  gtttatctg  4620
cccaaagga  aagcctcat  gggttgaca  aggtccttt  tgccatctc  gttccagct  4680
ctgtcaggg  ttaacaaca  agtgtaggg  agattaact  cctcccttc  aatagacac  4740
atcagcagg  acagatgtg  gggagtgca  ggctgcaga  ggtatgggg  gaggaggct  4800
ctaaaccct  tcccccagc  tcccccctg  cctgaagat  ttccatttg  ttccactca  4860
ctggaggct  aagagggct  gatggctgt  ccctgcccc  ctccttttg  tttgtacac  4920
gagaccaag  ggcctcagt  tagcacctt  gtacctccg  tgcttcact  gctttagcc  4980
aagccataa  aaacctgca  cgtagagaa  ataatgcag  taccctgac  agccagccc  5040
ctactcctc  aaccttttc  aagatatgc  atggccttt  tgcctgccc  aaggcttcg  5100
ccctccagt  catgaggaa  cctctttcc  ccgctcaga  atgctgctt  atttaccca  5160
gaggtcata  tctttatat  tattttttg  tgcaaagtg  ctctctaga  aaactctat  5220
tattattcg  atttttaaa  tatttgttt  tatataaaa  aaaagctca  ttggcaaaa  5280
aaaaaaaaa  aaa  5293



<210> 344
<211> 1384
<212> PRT
<213> Homo sapiens
<308> P78357
<400> 344

Met Met His Leu Arg Leu Phe Cys Ile Leu Leu Ala Ala Val Ser Gly 
  1               5                  10                  15
Ala Glu Gly Trp Gly Tyr Tyr Gly Cys Asp Glu Glu Leu Val Gly Pro 
             20                  25                  30
Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Ser Leu Leu Thr 
         35                  40                  45
Ala Pro Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro Arg 
     50                  55                  60
Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys His 
 65                  70                  75                  80
Arg Ile Arg Ala Val Ala Thr Gln Gly Ser Phe Asn Ser Trp Asp Trp 
                 85                  90                  95
Val Thr Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp Thr 
             100                105                110
Pro Phe Tyr Gln Arg Gly His Asn Ser Thr Phe Phe Gly Asn Val Asn 
         115                120                125
Glu Ser Ala Val Val Arg His Asp Leu His Phe His Phe Thr Ala Arg 
     130                135                140
Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile Gly 
 145                150                155                160
Leu Arg Leu Gly Leu Tyr Gly Cys Pro Tyr Lys Ala Asp Ile Leu Tyr 
                 165                170                175
Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Pro Arg Gly Val Ser 
             180                185                190
Arg Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Thr Glu Glu Lys 
         195                200                205
Asp Gly Leu Leu Leu His Ala Glu Gly Ala Gln Gly Asp Tyr Val Thr 
     210                215                220
Leu Glu Leu Glu Gly Ala His Leu Leu Leu His Met Ser Leu Gly Ser 
 225                230                235                240
Ser Pro Ile Gln Pro Arg Pro Gly His Thr Thr Val Ser Ala Gly Gly 
                 245                250                255
Val Leu Asn Asp Gln His Trp His Tyr Val Arg Val Asp Arg Phe Gly 
             260                265                270
Arg Asp Val Asn Phe Thr Leu Asp Gly Tyr Val Gln Arg Phe Ile Leu 
         275                280                285
Asn Gly Asp Phe Glu Arg Leu Asn Leu Asp Thr Glu Met Phe Ile Gly 
     290                295                300
Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn Phe 
 305                310                315                320
Arg Gly Cys Ile Glu Asn Val Ile Phe Asn Arg Val Asn Ile Ala Asp 
                 325                330                335
Leu Ala Val Arg Arg His Ser Arg Ile Thr Phe Glu Gly Lys Val Ala 
             340                345                350
Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly Pro 
         355                360                365
His Asn Phe Val Gln Val Pro Gly Phe Pro Arg Arg Gly Arg Leu Ala 
     370                375                380
Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr Gly Leu Leu Leu Phe 
 385                390                395                400
Ser Arg Leu Gly Asp Gly Leu Gly His Val Glu Leu Thr Leu Ser Glu 
                 405                410                415
Gly Gln Val Asn Val Ser Ile Ala Gln Ser Gly Arg Lys Lys Leu Gln 
             420                425                430
Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe Trp His Glu Val Asn 
         435                440                445
Phe Val Ala Gln Glu Asn His Ala Val Ile Ser Ile Asp Asp Val Glu 
     450                455                460
Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu Ile Arg Thr Gly Thr 
 465                470                475                480
Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala Ser Arg Trp Asp Cys 
                 485                490                495
His Ser Asn Gln Thr Ala Phe His Gly Cys Met Glu Leu Leu Lys Val 
             500                505                510
Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu Gly Arg Arg Leu Gly 
         515                520                525
Phe Tyr Ala Glu Val Leu Phe Asp Thr Cys Gly Ile Thr Asp Arg Cys 
     530                535                540
Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys Tyr Gln Ser Trp Asp 
 545                550                555                560
Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr Lys Gly Glu Thr Cys 
                 565                570                575
His Thr Pro Leu Tyr Lys Glu Ser Cys Glu Ala Tyr Arg Leu Ser Gly 
             580                585                590
Lys Thr Ser Gly Asn Phe Thr Ile Asp Pro Asp Gly Ser Gly Pro Leu 
         595                600                605
Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu Asn Arg Ala Trp Thr 
     610                615                620
Val Val Arg His Asp Arg Leu Trp Thr Thr Arg Val Thr Gly Ser Ser 
 625                630                635                640
Met Glu Arg Pro Phe Leu Gly Ala Ile Gln Tyr Trp Asn Ala Ser Trp 
                 645                650                655
Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln His Cys Glu Gln Trp 
             660                665                670
Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu Asn Thr Ala Gly Gly 
         675                680                685
Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu Glu Gln His Phe Tyr 
     690                695                700
Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys Ala Cys Gly Leu Asp 
 705                710                715                720
Arg Ser Cys Val Asp Pro Ala Leu Tyr Cys Asn Cys Asp Ala Asp Gln 
                 725                730                735
Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr Phe Val Asp His Leu 
             740                745                750
Pro Val Thr Gln Val Val Ile Gly Asp Thr Asn Arg Ser Thr Ser Glu 
         755                760                765
Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr Gly Asp Arg Asn Ser 
     770                775                780
Trp Asn Thr Ile Ser Phe His Thr Gly Ala Ala Leu Arg Phe Pro Pro 
 785                790                795                800
Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe Tyr Phe Arg Thr Ser 
                 805                810                815
Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly Gly Pro Tyr Cys Gln 
             820                825                830
Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn Thr Ser Arg Asp Val 
         835                840                845
Val Phe Ala Phe Asp Val Gly Asn Gly Asp Glu Asn Leu Thr Val His 
     850                855                860
Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp His Leu Val Arg Ala 
 865                870                875                880
Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val Asp His Arg Pro Trp 
                 885                890                895
Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile Trp Met Glu Tyr Asp 
             900                905                910
Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys Arg Arg Pro Phe Val 
         915                920                925
Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val Thr Leu Asn Leu Glu 
     930                935                940
Gly Arg Ala Asn Ala Ser Glu Gly Thr Ser Pro Asn Cys Thr Gly His 
 945                950                955                960
Cys Ala His Pro Arg Leu Pro Cys Phe His Gly Gly Arg Cys Val Glu 
                 965                970                975
Arg Tyr Ser Tyr Tyr Thr Cys Asp Cys Asp Leu Thr Ala Phe Asp Gly 
             980                985                990
Pro Tyr Cys Asn His Asp Ile Gly Gly Phe Phe Glu Pro Gly Thr Trp 
         995                1000                1005
Met Arg Tyr Asn Leu Gln Ser Ala Leu Arg Ser Ala Ala Arg Glu Phe 
     1010                1015                1020
Ser His Met Leu Ser Arg Pro Val Pro Gly Tyr Glu Pro Gly Tyr Ile 
 1025                1030                1035                1040
Pro Gly Tyr Asp Thr Pro Gly Tyr Val Pro Gly Tyr His Gly Pro Gly 
                 1045                1050                1055
Tyr Arg Leu Pro Asp Tyr Pro Arg Pro Gly Arg Pro Val Pro Gly Tyr 
             1060                1065                1070
Arg Gly Pro Val Tyr Asn Val Thr Gly Glu Glu Val Ser Phe Ser Phe 
         1075                1080                1085
Ser Thr Ser Ser Ala Pro Ala Val Leu Leu Tyr Val Ser Ser Phe Val 
     1090                1095                1100
Arg Asp Tyr Met Ala Val Leu Ile Lys Asp Asp Gly Thr Leu Gln Leu 
 1105                1110                1115                1120
Arg Tyr Gln Leu Gly Thr Ser Pro Tyr Val Tyr Gln Leu Thr Thr Arg 
                 1125                1130                1135
Pro Val Thr Asp Gly Gln Pro His Ser Ile Asn Ile Thr Arg Val Tyr 
             1140                1145                1150
Arg Asn Leu Phe Ile Gln Val Asp Tyr Phe Pro Leu Thr Glu Gln Lys 
         1155                1160                1165
Phe Ser Leu Leu Val Asp Ser Gln Leu Asp Ser Pro Lys Ala Leu Tyr 
     1170                1175                1180
Leu Gly Arg Val Met Glu Thr Gly Val Ile Asp Pro Glu Ile Gln Arg 
 1185                1190                1195                1200
Tyr Asn Thr Pro Gly Phe Ser Gly Cys Leu Ser Gly Val Arg Phe Asn 
                 1205                1210                1215
Asn Val Ala Pro Leu Lys Thr His Phe Arg Thr Pro Arg Pro Met Thr 
             1220                1225                1230
Ala Glu Leu Ala Glu Ala Leu Arg Val Gln Gly Glu Leu Ser Glu Ser 
         1235                1240                1245
Asn Cys Gly Ala Met Pro Arg Leu Val Ser Glu Val Pro Pro Glu Leu 
     1250                1255                1260
Asp Pro Trp Tyr Leu Pro Pro Asp Phe Pro Tyr Tyr His Asp Glu Gly 
 1265                1270                1275                1280
Trp Val Ala Ile Leu Leu Gly Phe Leu Val Ala Phe Leu Leu Leu Gly 
                 1285                1290                1295
Leu Val Gly Met Leu Val Leu Phe Tyr Leu Gln Asn His Arg Tyr Lys 
             1300                1305                1310
Gly Ser Tyr His Thr Asn Glu Pro Lys Ala Ala His Glu Tyr His Pro 
         1315                1320                1325
Gly Ser Lys Pro Pro Leu Pro Thr Ser Gly Pro Ala Gln Val Pro Thr 
     1330                1335                1340
Pro Thr Ala Ala Pro Asn Gln Ala Pro Ala Ser Ala Pro Ala Pro Ala 
 1345                1350                1355                1360
Pro Thr Pro Ala Pro Ala Pro Gly Pro Arg Asp Gln Asn Leu Pro Gln 
                 1365                1370                1375
Ile Leu Glu Glu Ser Arg Ser Glu 
             1380



<210> 345
<211> 5350
<212> DNA
<213> Rattus norvegicus
<308> AF000114
<400> 345

gggtaggag  aagggaagg  tgggtaagg  cggaaaaag  agcatcggt  agccgcgaa  60
cccaggaga  aasstgggg  cctgagcca  aaccggagc  ctagcggca  aagscagac  120
cccagggtt  gtcanctcc  catgatgag  ctccggctt  tcagcattc  gctcgccgc  180
gtggtctct  gagcccagg  ctggggcta  tatggctgc  atgaggagc  ggtggggcc  240
ctgtatgca  ggtctctgg  tgcttcctc  tactatgga  tctttacca  agcccgctt  300
gcccggcta  acggcatca  tggatggtc  ccccggatt  gggacccga  tccctggct  360
cagatagac  taatgaaga  gcatcgaat  cgggctgtg  ccacacagg  agcctttaa  420
tcttgggat  gggtcacac  ttacatgct  ctctacggg  accgtgtgg  cagctggac  480
ccattctac  aacaagggc  caacgcgac  ttcttcggt  atgtcaacg  ctcggcggt  540
gtacgccat  acctgcact  ccattttac  gctcgctac  tccgcatcg  gccactggc  600
tggaacccc  gcggcaaga  tggcttgag  ctgggcatc  acggttgtc  ctacacgtc  660
aacatcctg  attttgacg  cgatgatgc  atttcatac  gcttccagc  aggggccag  720
caaagtctt  gggacgtgt  cgcttttag  ttcaagaca  aggagaagg  cgggctgct  780
ttgcacacc  aaggctccc  gggggatta  gtgacgctt  aactgcaag  agcacacct  840
ctgctgcac  tgagcctgg  cagcagccc  atccagccg  gacctggtc  caccacggt  900
agcgctggt  gcgtactta  tgacctaag  tggcattat  tgcgggtgg  ccgatacgg  960
cgagaagca  atctcaccc  ggatggtta  gtacatcgc  ttgtgctca  cggcgactt  1020
gaaaggctg  atctcgaaa  tgagatatt  atcggaggt  tagtgggcg  agcgcgtaa  1080
aacctggcc  accgccata  cttccgtgg  tgtatagaa  acgtgatct  caaccggat  1140
aacatagct  aaatggcag  gcagcgcca  tcgcggatc  ccttcgagg  taatgtggc  1200
ttccggtgc  tggatcccg  tccacaccc  atcaacttc  gaggccctc  caacttcgt  1260
caagtgcct  gctttccac  tcgaggccg  cttgctgtc  ccttccgct  ccgcacctg  1320
gacctcaca  ggctgctcc  tttctcccg  ttgggggat  ggctgggtc  tgtggagct  1380
atgcttagt  aagggcaag  caatgtatc  atcgcgcag  ctggccgca  gaagcttca  1440
tttgctgcg  ggtaccgcc  gaatgatgg  ttctggcat  aggtgaact  tgtggcaca  1500
gaaaaccat  cggtcatca  tattgatga  gtggagggg  cagaggtca  ggtatcata  1560
ccactgctg  tccgcacag  gacttcata  ttctttggt  gttgtccca  accagccag  1620
cgatggggc  gccactcca  ccagacagc  ttccatggc  gcatggagc  gctcaaggt  1680
gatggtcaa  tggtcaacc  cactctggt  gagtttcgg  agcttggtt  ctttgctga  1740
gtcctcttt  acacatgtg  catcacaga  agatgcagc  ctaatatgt  tgagcatga  1800
gggcgctgc  accagtctt  ggatgactt  atctgctac  gcgaactca  cggctacaa  1860
ggagttacc  gccatgaac  attgtataa  gagtcctgt  aagcctatc  cctcagcgg  1920
aaatattct  gaaattaca  cattgatcc  gatggcagt  gacccctga  accatttgt  1980
gtgtattgt  atatccgag  gaaccgagc  tggacagtt  tgcgacatg  caggctatg  2040
accactcga  tgacaggtt  cagcatgga  cggcccttt  tgggggcca  ccaatactg  2100
aatgcctcc  gggaggaag  cagtgctct  gccaatgct  cccagcact  tgagcagtg  2160
atcgagttc  cctgctaca  ttcccggct  ctcaacact  caggaggct  cccctacag  2220
ttttggatt  gccgaaatg  agaacagca  ttctactgg  gaggctccc  gcctgggat  2280
caacgctgt  cctgtgggc  ggaccagag  tgtatagac  ctgcactgc  ctgcaactg  2340
gatgctgac  agccacagt  gagaacaga  aaggggctc  tgacctttg  ggaccatct  2400
cctgtcact  aggtagtga  aggtgacac  aaccgctcc  gctctgaag  tcagttctt  2460
ctgaggcct  tgcgctgtt  tggtgaccg  aattcctgg  acactatct  cttccgcac  2520
ggagctgca  tgcgtttcc  tccaatccg  gccaaccac  gccttgatg  ctccttcta  2580
ttcaggacc  cggctccct  aggagtctt  ctagagaac  tggggggtc  tttctgcca  2640
tggcgccga  cttacgtga  agtggagct  aacacatcc  gggatgtgg  ctttgcctt  2700
gatattggc  atggggatg  gaacctgac  gtgcactca  atgacttcg  gttcaatga  2760
gacgagtgg  atttggtcc  ggctgaaat  aacgtgaag  aggcccggc  gcgagtgga  2820
catcggccc  gggtgctaa  gcccatgcc  ctgcagacg  acatctggc  ggagtatga  2880
caacccctc  atgtgggat  tgcagagct  aagaggcgc  catttgtgg  gtgcttgag  2940
gccatgcgt  tgaatggag  gactctgaa  ttggagggt  gtgccaatg  ctccgaggg  3000
accttcccc  actgcacgg  ccactgcac  cacccccgg  tcccctgtt  ccacggagg  3060
cgctgtgtg  agcgataca  ctactacac  tgtgactgt  acctcacag  ttttgatgg  3120
ccatattgt  atcacgata  tggtggatt  tttgagact  gcacatgga  gcgctataa  3180
ctccagtca  cactgcgtt  tgcggccca  gagttctct  acatgctga  ccggccggt  3240
ccgggctat  agcctggct  tatcccagg  tacgacact  ctggttacg  gcctgggta  3300
catggtcct  ggtaccgcc  acccgacta  ccaaggcct  gccggccag  gcccggata  3360
cggggnccc  tgtacaatg  tactggaga  gaggtctcc  ttagcttca  caccagctc  3420
gctcctgca  tcctgctct  cgtcagctc  tttgtgcgt  actacatgg  cgtgctcat  3480
aaggaagat  ggaccctac  gcttcgcta  cagctgggc  ccagtccct  tgtgtacca  3540
ctaaccacc  ggccagtga  cgatggcca  ccccatagt  tcaacatca  ccgggtcta  3600
cgaaacctc  ttatccagg  ggactactt  ccgctgaca  aacagaagt  ctctctcct  3660
gtggacagc  agctggact  ccccaaggc  ttgtatcta  ggcgtgtga  ggagacagg  3720
gtcattgac  cagagattc  gcggtacaa  accccaggt  tctcaggct  cctgtctgg  3780
gtccggttc  acaatgtgg  tcctctcaa  acccatttc  gaacccctc  ccccatgac  3840
gctgagctg  cggaggcca  gcgggttca  ggagaactg  cggagtcta  ctgtggcgc  3900
atgccacgc  ttgtctccg  ggtgccacc  gagcttgat  cctggtacc  gcccccaga  3960
ttcccatac  accatgacg  cggatggat  gccatactc  taggttttt  ggtggcctt  4020
ctgctgctg  ggcttgtgg  aatgctggt  ctgttctat  tgcaaaatc  tcgatacaa  4080
ggctcctat  acaccaacg  gcccaaggc  acccatgat  cccaccctg  cggcaaagc  4140
cccctacct  cctcaggcc  tgcccaggc  cctgccccc  ctccagctc  cacccaggt  4200
ccgacccca  ccccagccc  agcctctgg  ccaggcccc  gggaccaga  cctccccca  4260
atcttggag  agtccaggt  tgaatgagt  acaagggct  cagggacca  ggccaactc  4320
tctaagtyc  ttmagctcc  gcctctcct  tcccctgtc  gggacattt  gctcttctt  4380
gcaggctct  ttcaccagg  ggatcccct  ttgccaagt  tggtgtgca  agctacaga  4440
gggaccaaa  ggagtggcc  agtctcact  cctaaacca  tgccctgcc  ccacccccc  4500
ccccagctc  tggctgttt  cctgcccta  gggagaaag  tcatggagc  gaggcgggc  4560
tttcctgcc  tctctgtcc  agctgctgg  aaggattaa  aaccaaggg  aggggagat  4620
aactgcctc  cttcctgtg  gtattatca  cagggacag  tgtggggga  cgaggggct  4680
cacagggca  gcagggagg  agggaggag  ctgctaaaa  acaccctgg  gcctccccc  4740
tgccctrct  accggctgt  ttccatctr  ttcctctca  ctggggttg  gggaagaac  4800
tcatcccca  cccccacct  acccaaccc  ttttgttct  acagagacc  agaggcctc  4860
gcttagtca  tttagtacc  ccactgctt  acatgcttt  gccaaagcc  taaaaagcc  4920
gcaagtaga  gaaataatg  agaccctgc  cagccagtc  tctgctcct  caccccttt  4980
caaaatacg  aatagcctg  gtgcctgtg  gcaggcctg  cccccctcc  tgcatgagg  5040
gccccccct  ccccgctca  agatgctgc  tgttcgtcc  ggaggtcat  ttctttata  5100
atatttttt  ttgcaaagc  tctctctag  gaactatat  ttactctaa  tttttaatt  5160
tctgtttat  tataaaaga  ctcagtggg  cgtcctgtg  tgtgcccag  ttgtagtga  5220
ctccttctg  gttggatgt  tcatgagtc  tgccagcca  tcacccgcc  gccgggcct  5280
cattctaga  cagggcaga  cccgctgtg  cctcacctg  gcaggttca  taaaagcag  5340
gtggcagaaa  5350



<210> 346
<211> 1381
<212> PRT
<213> Rattus norvegicus
<308> P97846
<400> 346

Met Met Ser Leu Arg Leu Phe Ser Ile Leu Leu Ala Ala Val Val Ser 
  1               5                  10                  15
Gly Ala Gln Gly Trp Gly Tyr Tyr Gly Cys Asn Glu Glu Leu Val Gly 
             20                  25                  30
Pro Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Gly Leu Phe 
         35                  40                  45
Thr Thr Ala Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro 
     50                  55                  60
Arg Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys 
 65                  70                  75                  80
His Arg Ile Arg Ala Val Ala Thr Gln Gly Ala Phe Asn Ser Trp Asp 
                 85                  90                  95
Trp Val Thr Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp 
             100                105                110
Thr Pro Phe Tyr Gln Gln Gly His Asn Ala Thr Phe Phe Gly Asn Val 
         115                120                125
Asn Asp Ser Ala Val Val Arg His Asp Leu His Tyr His Phe Thr Ala 
     130                135                140
Arg Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile 
 145                150                155                160
Gly Leu Arg Leu Gly Ile Tyr Gly Cys Pro Tyr Thr Ser Asn Ile Leu 
                 165                170                175
Tyr Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Gln Arg Gly Ala 
             180                185                190
Ser Gln Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Thr Glu Glu 
         195                200                205
Lys Asp Gly Leu Leu Leu His Thr Glu Gly Ser Gln Gly Asp Tyr Val 
     210                215                220
Thr Leu Glu Leu Gln Gly Ala His Leu Leu Leu His Met Ser Leu Gly 
 225                230                235                240
Ser Ser Pro Ile Gln Pro Arg Pro Gly His Thr Thr Val Ser Ala Gly 
                 245                250                255
Gly Val Leu Asn Asp Leu Ser Trp His Tyr Val Arg Val Asp Arg Tyr 
             260                265                270
Gly Arg Glu Ala Asn Leu Thr Leu Asp Gly Tyr Val His Arg Phe Val 
         275                280                285
Leu Asn Gly Asp Phe Glu Arg Leu Asn Leu Glu Asn Glu Ile Phe Ile 
     290                295                300
Gly Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn 
 305                310                315                320
Phe Arg Gly Cys Ile Glu Asn Val Ile Tyr Asn Arg Ile Asn Ile Ala 
                 325                330                335
Glu Met Ala Val Gln Arg His Ser Arg Ile Thr Phe Glu Gly Asn Val 
             340                345                350
Ala Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly 
         355                360                365
Pro His Asn Phe Val Gln Val Pro Gly Phe Pro Arg Arg Gly Arg Leu 
     370                375                380
Ala Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr Gly Leu Leu Leu 
 385                390                395                400
Phe Ser Arg Leu Gly Asp Gly Leu Gly His Val Glu Leu Met Leu Ser 
                 405                410                415
Glu Gly Gln Val Asn Val Ser Ile Ala Gln Thr Gly Arg Lys Lys Leu 
             420                425                430
Gln Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe Trp His Glu Val 
         435                440                445
Asn Phe Val Ala Gln Glu Asn His Ala Val Ile Ser Ile Asp Asp Val 
     450                455                460
Glu Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu Ile Arg Thr Gly 
 465                470                475                480
Thr Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala Ser Arg Trp Gly 
                 485                490                495
Cys His Ser Asn Gln Thr Ala Phe His Gly Cys Met Glu Leu Leu Lys 
             500                505                510
Val Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu Phe Arg Lys Leu 
         515                520                525
Gly Tyr Phe Ala Glu Val Leu Phe Asp Thr Cys Gly Ile Thr Asp Arg 
     530                535                540
Cys Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys Tyr Gln Ser Trp 
 545                550                555                560
Asp Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr Lys Gly Val Thr 
                 565                570                575
Cys His Glu Pro Leu Tyr Lys Glu Ser Cys Glu Ala Tyr Arg Leu Ser 
             580                585                590
Gly Lys Tyr Ser Gly Asn Tyr Thr Ile Asp Pro Asp Gly Ser Gly Pro 
         595                600                605
Leu Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu Asn Arg Ala Trp 
     610                615                620
Thr Val Val Arg His Asp Arg Leu Trp Thr Thr Arg Val Thr Gly Ser 
 625                630                635                640
Ser Met Asp Arg Pro Phe Leu Gly Ala Ile Gln Tyr Trp Asn Ala Ser 
                 645                650                655
Trp Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln His Cys Glu Gln 
             660                665                670
Trp Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu Asn Thr Ala Gly 
         675                680                685
Gly Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu Glu Gln His Phe 
     690                695                700
Tyr Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys Ala Cys Gly Leu 
 705                710                715                720
Asp Gln Ser Cys Ile Asp Pro Ala Leu His Cys Asn Cys Asp Ala Asp 
                 725                730                735
Gln Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr Phe Val Asp His 
             740                745                750
Leu Pro Val Thr Gln Val Val Ile Gly Asp Thr Asn Arg Ser Ser Ser 
         755                760                765
Glu Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr Gly Asp Arg Asn 
     770                775                780
Ser Trp Asn Thr Ile Ser Phe Arg Thr Gly Ala Ala Leu Arg Phe Pro 
 785                790                795                800
Pro Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe Tyr Phe Arg Thr 
                 805                810                815
Ser Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly Gly Pro Phe Cys 
             820                825                830
Gln Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn Thr Ser Arg Asp 
         835                840                845
Val Val Phe Ala Phe Asp Ile Gly Asn Gly Asp Glu Asn Leu Thr Val 
     850                855                860
His Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp His Leu Val Arg 
 865                870                875                880
Ala Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val Asp His Arg Pro 
                 885                890                895
Trp Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile Trp Leu Glu Tyr 
             900                905                910
Asp Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys Arg Arg Pro Phe 
         915                920                925
Val Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val Thr Leu Asn Leu 
     930                935                940
Glu Gly Arg Ala Asn Ala Ser Glu Gly Thr Phe Pro Asn Cys Thr Gly 
 945                950                955                960
His Cys Thr His Pro Arg Phe Pro Cys Phe His Gly Gly Arg Cys Val 
                 965                970                975
Glu Arg Tyr Ser Tyr Tyr Thr Cys Asp Cys Asp Leu Thr Ala Phe Asp 
             980                985                990
Gly Pro Tyr Cys Asn His Asp Ile Gly Gly Phe Phe Glu Thr Gly Thr 
         995                1000                1005
Trp Met Arg Tyr Asn Leu Gln Ser Ala Leu Arg Ser Ala Ala Gln Glu 
     1010                1015                1020
Phe Ser His Met Leu Ser Arg Pro Val Pro Gly Tyr Glu Pro Gly Tyr 
 1025                1030                1035                1040
Ile Pro Gly Tyr Asp Thr Pro Gly Tyr Val Pro Gly Tyr His Gly Pro 
                 1045                1050                1055
Gly Tyr Arg Leu Pro Asp Tyr Pro Arg Pro Gly Arg Pro Val Pro Gly 
             1060                1065                1070
Tyr Arg Gly Pro Val Tyr Asn Val Thr Gly Glu Glu Val Ser Phe Ser 
         1075                1080                1085
Phe Ser Thr Ser Ser Ala Pro Ala Val Leu Leu Tyr Val Ser Ser Phe 
     1090                1095                1100
Val Arg Asp Tyr Met Ala Val Leu Ile Lys Glu Asp Gly Thr Leu Gln 
 1105                1110                1115                1120
Leu Arg Tyr Gln Leu Gly Thr Ser Pro Tyr Val Tyr Gln Leu Thr Thr 
                 1125                1130                1135
Arg Pro Val Thr Asp Gly Gln Pro His Ser Val Asn Ile Thr Arg Val 
             1140                1145                1150
Tyr Arg Asn Leu Phe Ile Gln Val Asp Tyr Phe Pro Leu Thr Glu Gln 
         1155                1160                1165
Lys Phe Ser Leu Leu Val Asp Ser Gln Leu Asp Ser Pro Lys Ala Leu 
     1170                1175                1180
Tyr Leu Gly Arg Val Met Glu Thr Gly Val Ile Asp Pro Glu Ile Gln 
 1185                1190                1195                1200
Arg Tyr Asn Thr Pro Gly Phe Ser Gly Cys Leu Ser Gly Val Arg Phe 
                 1205                1210                1215
Asn Asn Val Ala Pro Leu Lys Thr His Phe Arg Thr Pro Arg Pro Met 
             1220                1225                1230
Thr Ala Glu Leu Ala Glu Ala Met Arg Val Gln Gly Glu Leu Ser Glu 
         1235                1240                1245
Ser Asn Cys Gly Ala Met Pro Arg Leu Val Ser Glu Val Pro Pro Glu 
     1250                1255                1260
Leu Asp Pro Trp Tyr Leu Pro Pro Asp Phe Pro Tyr Tyr His Asp Asp 
 1265                1270                1275                1280
Gly Trp Ile Ala Ile Leu Leu Gly Phe Leu Val Ala Phe Leu Leu Leu 
                 1285                1290                1295
Gly Leu Val Gly Met Leu Val Leu Phe Tyr Leu Gln Asn His Arg Tyr 
             1300                1305                1310
Lys Gly Ser Tyr His Thr Asn Glu Pro Lys Ala Thr His Asp Ser His 
         1315                1320                1325
Pro Gly Gly Lys Ala Pro Leu Pro Pro Ser Gly Pro Ala Gln Ala Pro 
     1330                1335                1340
Ala Pro Thr Pro Ala Pro Thr Gln Val Pro Thr Pro Ala Pro Ala Pro 
 1345                1350                1355                1360
Ala Ser Gly Pro Gly Pro Arg Asp Gln Asn Leu Pro Gln Ile Leu Glu 
                 1365                1370                1375
Glu Ser Arg Ser Glu 
             1380



<210> 347
<211> 5293
<212> DNA
<213> Homo sapiens
<308> U87223
<400> 347

caagagcgg  ggaccagga  ccagagaga  agagagaga  aagagagag  agagacaga  60
cgcttgggg  cgaaaggag  gagggaggg  agggtgggt  aggaggaga  agcggtctg  120
tgcaaaccc  aggaggaga  cttggagcc  aagccagaa  tcgagccct  gccggagcc  180
ttcacaggg  ggcggctgc  gggaccgtc  gccctgcat  atgcatctc  ggctcttct  240
catcctgct  gccgcggtc  caggagccg  gggctgggg  tactacggc  gcgacgagg  300
gctggtggg  cccctgtat  cacgctccc  gggcgcctc  tcctactac  gtctcctta  360
tgcgccgcg  ttcgccagg  tgcacggca  aagcgggtg  tcaccacgg  ttggggatc  420
gaatccctg  ctccagata  acttaatga  gaagcaccg  atccgggcc  tggccacac  480
gggctcctt  aattcttgg  actgggtca  acgttacat  ctactctac  gcgaccgag  540
ggacagctg  acaccgttc  accagcgag  gcacaactc  accttcttt  gtaacgtga  600
cgagtcggc  gtggtgcgc  atgacctgc  cttccactt  actgcgcgc  acatccgca  660
cgtgcccct  gcctggaac  cacgcggca  gatcggcct  aggctcggc  tctatggct  720
cccatacaa  gccgacata  tctatttcg  cggcgacga  gccatctcc  accgcttcc  780
gcgaggggt  agccgaagc  tgtgggacg  gttcgcctt  agcttcaag  ccgaggaga  840
ggacggtct  ctgctgcac  ccgagggcg  ccagggcga  tacgtgacg  tcgagctgg  900
gggggcaca  ctgctgctg  acatgagcc  gggcagcag  cctatccag  caagaccag  960
tcacaccac  gtgagcgca  gcggagtcc  caatgacca  cactggcac  atgtgcggg  1020
ggaccgatt  ggccgcgat  taaatttca  cctggacgg  tatgtgcag  gctttattc  1080
caatggaga  ttcgagagg  tgaacctgg  cactgagat  ttcatcgga  gtctggtgg  1140
cgccgcgcg  aagaacctg  cctatcggc  taacttccg  ggctgcata  aaaacgtaa  1200
cttcaaccg  gtcaacatc  cagacctgg  cgtgcggcg  cattcccgg  tcaccttcg  1260
gggtaaggt  gcttttcgt  gcctggacc  ggtaccgca  cctatcaac  tcggaggcc  1320
tcacaactt  gttcaagtg  ccggtttcc  acgccgtgg  cgcctggca  tctcatttc  1380
cttccgcac  tgggacctc  ccgggcttc  ccttttctc  cgtctgggg  acgggctgg  1440
ccacgtgga  ctgacgctc  gcgaagggc  ggtcaacgt  tccatcgcg  agagcggcc  1500
aaagaagct  cagttcgct  ctgggtacc  actgaatga  ggcttttgg  acgaggtga  1560
ttttgtggc  caggaaaac  atgcagtta  cagcattga  gatgtggaa  gggcagagg  1620
cagggtctc  tacccgttg  tgatccgga  agggacctc  tatttcttt  ggggttgtc  1680
caagccagc  agtcgatgg  actgccact  caaccagac  gcattccat  gctgcatgg  1740
gctgctcaa  gtggatggt  aactggtca  cctgactct  gtggagggc  ggcggcttg  1800
attctatgc  gaggtcctc  ttgatacat  tggcatcac  gataggtgc  gccctaaca  1860
gtgtgagca  gatggacgc  gctaccagt  ttgggatga  ttcatttgc  actgcgaac  1920
gacgggcta  aagggagag  cctgccaca  acctttgta  aaggaatcc  gtgaggctt  1980
tcggctcag  gggaaaact  ctggaaact  caccattga  cctgatggc  gtggccccc  2040
gaagccatt  gtagtgtac  gtgatatcc  agagaaccg  gcgtggaca  ttgtgcggc  2100
tgacaggct  tggacaact  gagtgacag  ttccagcat  gagcggcca  tcctggggg  2160
tatccagta  tggaatgca  cctgggagg  agtcagtgc  cttgccaat  cttcccagc  2220
ttgtgaaca  tggatcgag  tctcctgct  caattcccg  ctgctcaac  ctgcaggag  2280
ctaccccta  agcttttgg  ttggccgaa  tgaggagca  cacttctac  ggggaggct  2340
ccagcctgg  atccagcgc  gtgcctgtg  tctggaccg  agctgtgtg  accctgcct  2400
gtactgcaa  tgtgacgct  accagcccc  gtggagaac  gacaaggga  tgctgacct  2460
tgtggacca  ctgcctgtc  ctcaggtag  gatagggga  acgaaccgc  ccacttctg  2520
ggcccagtt  ttcctgagg  ctctgcgct  ctatggcga  cgaaattcc  ggaacacca  2580
ttccttcca  accggggct  cactacgct  ccccccaat  cgtgccaac  acagcctgg  2640
tgtctcctt  tacttcagg  cctctgctc  ctcgggggt  ttcctagag  atatggggg  2700
cccttactg  cagtggcgc  gaccttatg  gcgggtgga  ctcaacaca  cccgggatg  2760
ggtcttcgc  tttgatgtg  ggaatgggg  tgagaacct  acagtacac  cagacgact  2820
tgagttcaa  gatgacgag  ggcacctgg  ccgggctga  atcaacgtg  agcaggccc  2880
gctccgagt  gatcaccgg  cctgggttc  gcggcctat  ccactgcag  cctacatct  2940
gatggagta  gaccagccc  tctatgtgg  atctgcaga  cttaagaga  gcccctttg  3000
gggttgctt  agggccatg  gtctgaacg  agtgactct  aacctggag  gccgtgcca  3060
tgcctctga  ggtacctca  ccaactgca  aggccactg  gcccaccct  ggctcccct  3120
tttccatgg  ggccgctgc  tggagcgct  tagctacta  acgtgtgac  gtgacctca  3180
ggcttttga  gggccatac  gcaaccacg  tattggtgg  ttctttgag  cgggcacct  3240
gatgcgcta  aacctacag  cagcgctgc  ctctgcagc  agggagttc  cccacatgc  3300
gagccggcc  gtgccaggc  atgagcctg  ctacatccc  ggctatgat  ctccgggct  3360
tgtgcctgg  taccatggc  ccgggtacc  cctgcccga  tacccccgg  ctggtcggc  3420
tgtgcccgg  taccgtggg  ctgtctaca  cgttacggg  gaggaggtc  ccttcagct  3480
cagcaccag  tccgcccct  ctgtcctgc  ctacgtcag  tcctttgtt  gtgactaca  3540
ggctgtgct  atcaaggat  atgggaccc  tcagctgcg  tatcagctg  gcaccagtc  3600
ctacgtgta  cagctaacc  ctcgaccag  gaccgatgg  cagccccat  gcatcaata  3660
cacccgtgt  taccggaac  tcttcatcc  ggtggacta  ttcccactg  cagagcaga  3720
gttctcgct  ttggtggac  gccagttgg  ctcacccaa  gccttgtat  tagggcgtg  3780
gatggagac  ggagtcatt  acccggaga  ccagcgcta  aacacccca  gtttctcag  3840
ctgcctgtc  ggtgttcga  tcaacaacg  ggctcccct  aagacccac  tccgaaccc  3900
tcgacccat  actgctgag  tagctgagg  ccttcgagt  cagggagaa  tgtccgaat  3960
taattgcgg  gctatgcca  gtcttgttt  agaggtgcc  cctgagctt  atccctggt  4020
tctgccccc  gacttcccc  actaccatg  tgaaggatg  gttgccata  ttttaggct  4080
tttggtggc  tttctgctg  tggggctgg  gggaatgtt  gtgctcttc  atctgcaaa  4140
tcatcgcta  aagggctcc  accatacca  tgagcccaa  gctgcccac  agtaccatc  4200
tggcagcaa  cctccccta  ccacttcag  ccctgccca  gtccccacc  ctacagcag  4260
tcccaacca  gctccagcc  cagccccag  cccagcccc  actccagcc  cagcccctg  4320
cccccggga  cagaaccta  cccagatcc  ggaggagtc  aggtctgaa  gagtcagaa  4380
ggcttctgg  accaattcc  gctcctgac  ttcccccag  cctgcctct  ccccatcct  4440
tcagggaca  ttggctcct  ttagctggc  ctgctcatc  agaggatat  cccccatcc  4500
ccccccatc  agtttggtg  gcagagcta  agatgggac  caagggagt  gccgagcct  4560
actgcctaa  ccaatgccc  tctcatccc  gtttcccca  gctcctggc  gtttatctg  4620
cccaaagga  aagcctcat  gggttgaca  aggtccttt  tgccatctc  gttccagct  4680
ctgtcaggg  ttaacaaca  agtgtaggg  agattaact  cctcccttc  aatagacac  4740
atcagcagg  acagatgtg  gggagtgca  ggctgcaga  ggtatgggg  gaggaggct  4800
ctaaaccct  tcccccagc  tcccccctg  cctgaagat  ttccatttg  ttccactca  4860
ctggaggct  aagagggct  gatggctgt  ccctgcccc  ctccttttg  tttgtacac  4920
gagaccaag  ggcctcagt  tagcacctt  gtacctccg  tgcttcact  gctttagcc  4980
aagccataa  aaacctgca  cgtagagaa  ataatgcag  taccctgac  agccagccc  5040
ctactcctc  aaccttttc  aagatatgc  atggccttt  tgcctgccc  aaggcttcg  5100
ccctccagt  catgaggaa  cctctttcc  ccgctcaga  atgctgctt  atttaccca  5160
gaggtcata  tctttatat  tattttttg  tgcaaagtg  ctctctaga  aaactctat  5220
tattattcg  atttttaaa  tatttgttt  tatataaaa  aaaagctca  ttggcaaaa  5280
aaaaaaaaa  aaa  5293



<210> 348
<211> 1384
<212> PRT
<213> Homo sapiens
<308> P78357
<400> 348

Met Met His Leu Arg Leu Phe Cys Ile Leu Leu Ala Ala Val Ser Gly 
  1               5                  10                  15
Ala Glu Gly Trp Gly Tyr Tyr Gly Cys Asp Glu Glu Leu Val Gly Pro 
             20                  25                  30
Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Ser Leu Leu Thr 
         35                  40                  45
Ala Pro Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro Arg 
     50                  55                  60
Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys His 
 65                  70                  75                  80
Arg Ile Arg Ala Val Ala Thr Gln Gly Ser Phe Asn Ser Trp Asp Trp 
                 85                  90                  95
Val Thr Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp Thr 
             100                105                110
Pro Phe Tyr Gln Arg Gly His Asn Ser Thr Phe Phe Gly Asn Val Asn 
         115                120                125
Glu Ser Ala Val Val Arg His Asp Leu His Phe His Phe Thr Ala Arg 
     130                135                140
Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile Gly 
 145                150                155                160
Leu Arg Leu Gly Leu Tyr Gly Cys Pro Tyr Lys Ala Asp Ile Leu Tyr 
                 165                170                175
Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Pro Arg Gly Val Ser 
             180                185                190
Arg Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Thr Glu Glu Lys 
         195                200                205
Asp Gly Leu Leu Leu His Ala Glu Gly Ala Gln Gly Asp Tyr Val Thr 
     210                215                220
Leu Glu Leu Glu Gly Ala His Leu Leu Leu His Met Ser Leu Gly Ser 
 225                230                235                240
Ser Pro Ile Gln Pro Arg Pro Gly His Thr Thr Val Ser Ala Gly Gly 
                 245                250                255
Val Leu Asn Asp Gln His Trp His Tyr Val Arg Val Asp Arg Phe Gly 
             260                265                270
Arg Asp Val Asn Phe Thr Leu Asp Gly Tyr Val Gln Arg Phe Ile Leu 
         275                280                285
Asn Gly Asp Phe Glu Arg Leu Asn Leu Asp Thr Glu Met Phe Ile Gly 
     290                295                300
Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn Phe 
 305                310                315                320
Arg Gly Cys Ile Glu Asn Val Ile Phe Asn Arg Val Asn Ile Ala Asp 
                 325                330                335
Leu Ala Val Arg Arg His Ser Arg Ile Thr Phe Glu Gly Lys Val Ala 
             340                345                350
Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly Pro 
         355                360                365
His Asn Phe Val Gln Val Pro Gly Phe Pro Arg Arg Gly Arg Leu Ala 
     370                375                380
Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr Gly Leu Leu Leu Phe 
 385                390                395                400
Ser Arg Leu Gly Asp Gly Leu Gly His Val Glu Leu Thr Leu Ser Glu 
                 405                410                415
Gly Gln Val Asn Val Ser Ile Ala Gln Ser Gly Arg Lys Lys Leu Gln 
             420                425                430
Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe Trp His Glu Val Asn 
         435                440                445
Phe Val Ala Gln Glu Asn His Ala Val Ile Ser Ile Asp Asp Val Glu 
     450                455                460
Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu Ile Arg Thr Gly Thr 
 465                470                475                480
Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala Ser Arg Trp Asp Cys 
                 485                490                495
His Ser Asn Gln Thr Ala Phe His Gly Cys Met Glu Leu Leu Lys Val 
             500                505                510
Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu Gly Arg Arg Leu Gly 
         515                520                525
Phe Tyr Ala Glu Val Leu Phe Asp Thr Cys Gly Ile Thr Asp Arg Cys 
     530                535                540
Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys Tyr Gln Ser Trp Asp 
 545                550                555                560
Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr Lys Gly Glu Thr Cys 
                 565                570                575
His Thr Pro Leu Tyr Lys Glu Ser Cys Glu Ala Tyr Arg Leu Ser Gly 
             580                585                590
Lys Thr Ser Gly Asn Phe Thr Ile Asp Pro Asp Gly Ser Gly Pro Leu 
         595                600                605
Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu Asn Arg Ala Trp Thr 
     610                615                620
Val Val Arg His Asp Arg Leu Trp Thr Thr Arg Val Thr Gly Ser Ser 
 625                630                635                640
Met Glu Arg Pro Phe Leu Gly Ala Ile Gln Tyr Trp Asn Ala Ser Trp 
                 645                650                655
Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln His Cys Glu Gln Trp 
             660                665                670
Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu Asn Thr Ala Gly Gly 
         675                680                685
Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu Glu Gln His Phe Tyr 
     690                695                700
Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys Ala Cys Gly Leu Asp 
 705                710                715                720
Arg Ser Cys Val Asp Pro Ala Leu Tyr Cys Asn Cys Asp Ala Asp Gln 
                 725                730                735
Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr Phe Val Asp His Leu 
             740                745                750
Pro Val Thr Gln Val Val Ile Gly Asp Thr Asn Arg Ser Thr Ser Glu 
         755                760                765
Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr Gly Asp Arg Asn Ser 
     770                775                780
Trp Asn Thr Ile Ser Phe His Thr Gly Ala Ala Leu Arg Phe Pro Pro 
 785                790                795                800
Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe Tyr Phe Arg Thr Ser 
                 805                810                815
Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly Gly Pro Tyr Cys Gln 
             820                825                830
Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn Thr Ser Arg Asp Val 
         835                840                845
Val Phe Ala Phe Asp Val Gly Asn Gly Asp Glu Asn Leu Thr Val His 
     850                855                860
Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp His Leu Val Arg Ala 
 865                870                875                880
Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val Asp His Arg Pro Trp 
                 885                890                895
Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile Trp Met Glu Tyr Asp 
             900                905                910
Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys Arg Arg Pro Phe Val 
         915                920                925
Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val Thr Leu Asn Leu Glu 
     930                935                940
Gly Arg Ala Asn Ala Ser Glu Gly Thr Ser Pro Asn Cys Thr Gly His 
 945                950                955                960
Cys Ala His Pro Arg Leu Pro Cys Phe His Gly Gly Arg Cys Val Glu 
                 965                970                975
Arg Tyr Ser Tyr Tyr Thr Cys Asp Cys Asp Leu Thr Ala Phe Asp Gly 
             980                985                990
Pro Tyr Cys Asn His Asp Ile Gly Gly Phe Phe Glu Pro Gly Thr Trp 
         995                1000                1005
Met Arg Tyr Asn Leu Gln Ser Ala Leu Arg Ser Ala Ala Arg Glu Phe 
     1010                1015                1020
Ser His Met Leu Ser Arg Pro Val Pro Gly Tyr Glu Pro Gly Tyr Ile 
 1025                1030                1035                1040
Pro Gly Tyr Asp Thr Pro Gly Tyr Val Pro Gly Tyr His Gly Pro Gly 
                 1045                1050                1055
Tyr Arg Leu Pro Asp Tyr Pro Arg Pro Gly Arg Pro Val Pro Gly Tyr 
             1060                1065                1070
Arg Gly Pro Val Tyr Asn Val Thr Gly Glu Glu Val Ser Phe Ser Phe 
         1075                1080                1085
Ser Thr Ser Ser Ala Pro Ala Val Leu Leu Tyr Val Ser Ser Phe Val 
     1090                1095                1100
Arg Asp Tyr Met Ala Val Leu Ile Lys Asp Asp Gly Thr Leu Gln Leu 
 1105                1110                1115                1120
Arg Tyr Gln Leu Gly Thr Ser Pro Tyr Val Tyr Gln Leu Thr Thr Arg 
                 1125                1130                1135
Pro Val Thr Asp Gly Gln Pro His Ser Ile Asn Ile Thr Arg Val Tyr 
             1140                1145                1150
Arg Asn Leu Phe Ile Gln Val Asp Tyr Phe Pro Leu Thr Glu Gln Lys 
         1155                1160                1165
Phe Ser Leu Leu Val Asp Ser Gln Leu Asp Ser Pro Lys Ala Leu Tyr 
     1170                1175                1180
Leu Gly Arg Val Met Glu Thr Gly Val Ile Asp Pro Glu Ile Gln Arg 
 1185                1190                1195                1200
Tyr Asn Thr Pro Gly Phe Ser Gly Cys Leu Ser Gly Val Arg Phe Asn 
                 1205                1210                1215
Asn Val Ala Pro Leu Lys Thr His Phe Arg Thr Pro Arg Pro Met Thr 
             1220                1225                1230
Ala Glu Leu Ala Glu Ala Leu Arg Val Gln Gly Glu Leu Ser Glu Ser 
         1235                1240                1245
Asn Cys Gly Ala Met Pro Arg Leu Val Ser Glu Val Pro Pro Glu Leu 
     1250                1255                1260
Asp Pro Trp Tyr Leu Pro Pro Asp Phe Pro Tyr Tyr His Asp Glu Gly 
 1265                1270                1275                1280
Trp Val Ala Ile Leu Leu Gly Phe Leu Val Ala Phe Leu Leu Leu Gly 
                 1285                1290                1295
Leu Val Gly Met Leu Val Leu Phe Tyr Leu Gln Asn His Arg Tyr Lys 
             1300                1305                1310
Gly Ser Tyr His Thr Asn Glu Pro Lys Ala Ala His Glu Tyr His Pro 
         1315                1320                1325
Gly Ser Lys Pro Pro Leu Pro Thr Ser Gly Pro Ala Gln Val Pro Thr 
     1330                1335                1340
Pro Thr Ala Ala Pro Asn Gln Ala Pro Ala Ser Ala Pro Ala Pro Ala 
 1345                1350                1355                1360
Pro Thr Pro Ala Pro Ala Pro Gly Pro Arg Asp Gln Asn Leu Pro Gln 
                 1365                1370                1375
Ile Leu Glu Glu Ser Arg Ser Glu 
             1380



<210> 349
<211> 9316
<212> DNA
<213> Rattus norvegicus
<308> AF000368
<400> 349

atggcgatg  tgcctcctc  aggacctca  agtttcgtt  acttcacaa  acagtccct  60
gccctcatt  aacagcgta  ttctgaaga  aaagccaag  aacacaaag  cgaaaagaa  120
gatgatgag  aagaaggcc  caagcccag  agtgacttg  aagctggga  acagctccc  180
ttcatctat  gagacattc  ccctggaat  gtgtcagag  ccctggagg  cctggaccc  240
tactatgct  acaaaaaaa  ttttatagt  ttgaacaaa  ggaaagcaa  cttccgttt  300
aacgccacc  ctgctttgt  catgctgtc  cccttcagt  ctctaagaa  aatatctat  360
aagatctta  tgcactcct  attcagcat  ctaatcatg  gcacaattc  gacgaactg  420
atattcatg  ccttgagca  ccctccaga  tggaccaaa  atgtagagt  cacttttac  480
gggatatat  cttttgaat  actcataaa  atccttgca  gaggctttt  cgtgggaga  540
ttcaccttc  tccgtgacc  ttggaactg  ctggacttt  ttgtcattg  ttttgcgta  600
ttaacagaa  ttgtaaacc  aggcaatgt  tcagctctt  gaactttca  agtcttgag  660
gctttgaaa  ctatttctg  aatcccagg  ctaaagacc  tcgtggggg  cctgatcca  720
tcagtgaag  agctctctg  cgtcatgat  ctcactgtg  tctgtctca  tgtgtttgc  780
ctaattgga  tacagctgt  tatgggcaa  ttgaagcat  aatgtttca  gaaggaact  840
gaagagaat  aaacattag  aagtatcat  aatactgct  agagtgaag  agaattgaa  900
aaatatttt  attacttgg  gggatccaa  gatgctcta  tctgcggct  cagcacaga  960
tcagggcag  gtccagaag  ctacatctg  gtgaaggct  gcagaaacc  ggattatgg  1020
tacacgagc  ttgacacat  cagctgggc  ttcttggcc  tgtttcggc  aatgactca  1080
gactactgg  agaaccttt  ccaacagac  ctgcgtgct  ctggcaaaa  ctacatgat  1140
ttctttgtc  tggttattt  tctgggctc  ttttacctg  taaacttga  cctggctgt  1200
gtagccatg  cgtatgagg  acagaacca  gccaacatc  aagaagcta  acagaaaga  1260
ttagaattt  agcagatgt  agaccgact  aaaaaggag  aggaagaag  tgaggcgat  1320
gctgcagct  ctgctgagt  cacgagtat  gggcggagc  ggatcatgg  actctctga  1380
agctcttca  aaacctcca  gctgagctc  aagagtgcc  aggagagaa  aaaccgaag  1440
aagaaaaag  aacagaaga  gtccagtgg  gaggaaaag  gtgacgatg  gaagctgtc  1500
aagtcagga  cagaggaaa  catccgaaa  aaaagtttc  atctcggtg  ggaagggca  1560
caccggacc  gggaaaaga  gctgtccac  cccaaccag  cgccactca  cattcgcgg  1620
tccctgttt  ctgccaggc  cagcagcag  acgagtctc  tcagtttta  ggggcgagg  1680
agagatctg  gatctgaga  agaattcgc  gatgatgag  atagcattt  tggagacaa  1740
gagagcaga  ggggttcac  attcgtacc  catagaccc  gggagcggc  cagcagtaa  1800
atcagtcag  ccagtaggt  cccgccagt  ctaccggtg  acgggaaga  gcacagtgc  1860
gtggactgc  atggcgtcg  gtcgcttgt  gatggaccc  cagccctca  gctccccaa  1920
ggacagctt  ttccagagg  gataataga  aaggcaact  ccgacgaca  cggcacgac  1980
aatcagatg  gcaaaaaaa  gctctctag  tcttacttc  tgtctgagg  catgctgaa  2040
gacccgcat  tcaggcaaa  ggccatgag  agggcgagc  tactgacca  cactgtgga  2100
gaacttgaa  aatctagac  aaaatgtcc  ccatggtgg  acagatttg  tcacacatt  2160
ttaatctgg  attgctctc  atattggat  aaattcaaa  agctcatct  ttttattgt  2220
atggatcct  ttgtagatc  tgcaattac  atttgcata  ttttaaaca  cttatttat  2280
gctatggag  accacccaa  gactgaaga  ttcaaaaat  tccttgcag  ggggaactt  2340
atctttaca  ggatcttcg  agctgaaat  gtactgaag  taatagcca  ggaccccta  2400
gagtatttc  aagtagggt  gaatatttt  gacagccta  ttgtgacgc  gagtttgat  2460
gagcttttc  tagcagatg  ggaaggatt  tcagttctg  ggtcattca  attgctccg  2520
gtcttcaag  tggcaaagt  ctggcccac  ctgaacatg  tcattaaga  catcggcaa  2580
tcggtgggc  cactgggca  cctgaccct  gtgctggcc  tcatcgtct  catttttgc  2640
gtggtcggc  tgcagctgt  tggaaagag  tacaaggag  gtgtctgca  gatcaatgt  2700
gactgcaag  tgccgcgct  gcacatgaa  gacttcttc  actccttcc  catcgtgtt  2760
cgagtgctg  gtggggagt  gatagagac  atgtgggac  gcatggagg  cgcgggcca  2820
accatgtgc  ttattgttt  catgatggt  atggtgatt  ggaaccttg  ggtcctgaa  2880
ctgtttctg  ctcttttgc  gagttcctt  agttctgac  atcttacag  aattgagga  2940
gacaccgat  caaacaacc  ccagatcgc  gtggccaga  ttaagaggg  aatcaatta  3000
gtgaaacag  ccctgcgtg  attcattct  aaatcattt  ccaaaaagc  aaagggctc  3060
aaggacaca  aacgaacag  agatcccaa  aacaagaaa  aaaactata  ttcaaaccg  3120
acccttgcg  agatgagca  ggatcacaa  ttcctcaaa  aaaaggata  gatcagtgg  3180
tatggcagc  gtctagaca  aagctttat  gatgaaaat  attaccagt  ctttatcca  3240
aaccccagc  tcacagtga  agtgccaat  gcacctggg  agtctgatt  ggagattat  3300
aacacagaa  agcttagca  tgactcaga  agtgactac  gcaaagaga  acggaaccg  3360
tcaagctct  ctgagtgca  cactgttga  aaccctctg  caggagaag  ggaggctga  3420
gcagagccc  taaacgcag  tgagcctga  gcctgcttt  cagatggtt  tgtgaggag  3480
tttccatgc  gccaagtta  tgtagactc  gggaaaggg  aagtttggt  gaccatcag  3540
aagacgtgc  acaggatag  tgaacacag  tggtttgaa  gcttcatcg  tctcatgat  3600
ctgctcagc  gtggagctc  ggcttttga  gatatctat  ttgaaaaga  aaagaccat  3660
aagattatc  tggagtatg  tgacaagat  ttcacctac  tcttcattc  ggaaatgct  3720
ctaaaatgg  tcgcatatg  gtataaaac  tatttcact  atgcctggt  ttggctgga  3780
ttcttaatt  ttgatgtgt  tctagttac  ttagtagcc  acactcttg  ctactcaga  3840
cttggcccc  ttaaatctc  acggacact  agggcccta  gacccctaa  agccttgtc  3900
agatttgaa  gaatgaggg  agtggtcaa  gcactcata  gagcaatcc  ttccatcat  3960
aacgtgctt  tcgtgtgcc  tatattctg  ctaatattt  gcatcatgg  agtcaatct  4020
tttgctggc  agttctatg  gtgtgtcaa  accaccgat  ggtcacgat  tcctacatc  4080
caagttgca  accgttctg  gtgttttgc  ctgatgaac  ttagtggaa  tgtgcgatg  4140
aaaaacctg  aagtaaact  cgacaacgt  gggcttggt  acctgtcgc  gcttcaagt  4200
gcaacattc  agggctgga  ggatattat  tatgcagca  ttgactctg  taatgtaaa  4260
gaacagccg  aatacgaat  cagtctcta  atgtacatt  actttgtca  cttcatcat  4320
ttcggctca  tcttcacgt  gaacctgtt  attggtgtc  tcatagata  tttcaacca  4380
cagaaaaaa  agcttggag  tcaagatat  tttatgaca  aagaacaga  gaaatacta  4440
aatgcaatg  agaagcttg  gtccaaaaa  ccacaaaaa  caattccaa  gccagggaa  4500
aaattccaa  gatgtatat  tgacttagt  acaaaccaa  cttttgata  caccatcat  4560
gttcttata  gcctcaaca  ggtaaccat  atggtagaa  aagaggggc  aactgagta  4620
atggattat  ttttacact  gatcaacat  gtcttcatt  tcctgttca  tggggagtg  4680
gtgctgaag  taatctccc  cagacatta  tacttcact  tgggttgga  catttttga  4740
tttgtggta  tgatcctct  cattgtagg  atgtttctc  ctgagatga  agagaagta  4800
ttcgtgtcc  ctaccctgt  ccgagtcat  cgcctggcc  ggattggac  aatcctacg  4860
ctgatcaaa  gcgccaagg  gatccgcac  ctgctcttt  ctttgatga  gtcccttcc  4920
gcgctgttc  acatcggcc  cctgctttt  ctggtcatg  tcatctacg  catctttgg  4980
atgtccaac  ttgcctacg  taaaaagga  gctggaatt  atgacatgt  caactttga  5040
acttttggc  acagcatga  ctgcttgtt  caaatcacc  cctctgccg  ctgggacgg  5100
ctgctggcc  ccatcctca  cagcgcacc  cccgactgt  accctaaaa  agttcaccc  5160
ggaagttca  tggaagggg  ctgtgggaa  ccatccgtg  ggatttttt  ctttgtcag  5220
tacatcatc  tatccttcc  ggtggtggt  aacatgtac  tcgctgtca  cctggagaa  5280
ttcagcgtc  ccaccgaag  gagcactga  cctctgagt  aggacgact  tgagatgtt  5340
tacgaggtc  gggagaagt  cgaccctga  gccactcag  tcatagagt  ctgcaagct  5400
tctgacttt  cagctgccc  ggatcctcc  ctcctcatc  caaagccaa  caaagtcca  5460
ctcattgcc  tggacctgc  catggtgag  ggagaccgc  tccactgcc  ggacatctt  5520
tttgctttt  caaagcggg  cctgggtga  ggtggagag  tggattctc  tcgttcaca  5580
atggaagaa  ggttcatgt  agccaatcc  tctaaagtg  cctatgaac  catcacgac  5640
acactgaag  gaaaacaag  ggaggtgtc  gcgactatc  ttcagcgtg  ttacagacg  5700
tatcgcctc  gacaacacg  caagaatat  tcgagtata  acataaaag  tggagacag  5760
gatgatgat  tgcccaata  agaagatac  gtttttgat  acgtgaacg  gaactcaag  5820
ccggaaaag  cagatgtaa  tgcctcaac  atctcgcca  cttcctatg  cagtgtcac  5880
aagccagat  aagagaaat  tgaaacaga  aaaacagag  aggaagaca  agagaaaga  5940
gaaagcagg  aatagagct  tggttttga  acactgttg  cagcctgtg  aggttgact  6000
actcgtgtt  gtaagactc  tttacggag  tctatgcca  actcttttt  tcaaaaaat  6060
ctcaaaggc  gcacagcca  tagctctga  ccaacgagg  agagggcag  atttacaca  6120
ggctatgtt  tgctttggt  aatgattct  ttaagattt  agagtgtaa  tctgaaggg  6180
agagccatc  ctgcattca  gggtgactt  gacattcta  aaatcagaa  accaagtca  6240
acattttct  atttgcctc  atgtctttt  tctaggttc  aaataaatg  gcacccatg  6300
gaatctaga  atccaggca  acatgcaca  atgcacaca  tcacaaata  aaacaggat  6360
ggctacgat  tcaaattct  tgtaaatgt  tcactttgg  ttgcaatga  atttccttg  6420
aaaggaaat  ggattagtg  cgaaggttt  gtcaaaaca  cttattatt  gggaatcag  6480
atctttaat  taaaaagaa  tcagtttat  tttttgagg  gctgaaact  atcctacat  6540
gcgtcaaaa  caacttata  gaatctata  gatgtcatg  aattgaaaa  cgtatgtgg  6600
ctatttatt  aagaaatca  tttcatttg  atattagca  cattcacct  gatttatgg  6660
catcttgga  attgtgtgg  cacatgatg  tcccacaaa  ttgtttagc  gaaacttca  6720
gcacacatc  cagagaaca  ctacccagt  ttacgctcc  ccctgttca  acaataacc  6780
cagaccttt  aacattatt  ggaatataa  tattaggtt  ctcaatata  acatgtgaa  6840
attaacaga  aagttaatt  acagcgttt  acttactaa  gtctatcca  tctagtttg  6900
acaatgaga  agctctcac  tcttacagc  agttgccac  tttctcttc  tacgaagct  6960
cggtttgtc  gactttatc  ctaagcaaa  tctatgttt  ctttttaat  aaacgtatc  7020
tgaaaagcg  ttagctact  gatacttta  tgcttgttt  agcagatga  tggagcatg  7080
tatgtaccc  atcttttaa  atacaatcc  taatgtgtt  ggcagcttc  caagttaca  7140
ggaacgccg  gcttttaat  tctctccgt  caccaggtg  tttgtatga  tgaaatgac  7200
ttcaaagag  gagtctcat  ggcttgctt  attaccaac  actttccta  atgaggaac  7260
aatcctctg  agcactatt  tatcccctt  taaataaca  agatgtcac  tcgttctta  7320
tattctaat  catggtgtg  catatattt  gcattgatc  gtaaagtag  ctgggataa  7380
cattttaag  gcatataca  tttgaggta  gtgaagtta  tctaccaag  attagaaac  7440
tactccaag  ttttaaagt  cttgataaa  atgaatgac  ctgacaaat  ctctcataa  7500
tttattcca  caatgtgaa  tctttcctc  aacacttta  ccttgcaga  aagaaagaa  7560
aaacaaaga  aagcccatg  gccatgtaa  caaaggggc  ttatctaga  gattctgag  7620
gaacctttg  agtaaatat  taaaacata  ttcctcagt  tgcctttga  attaaaaag  7680
aacacaaaa  tatggattt  ataagtcat  aaaacacat  ctttatttc  ggcccagtt  7740
aaaggaaag  attaaaaat  cctatagag  gggggggac  gagagagaa  gagggagag  7800
agaaacaaa  tactaggga  aaaaagatt  gacagaata  gtccaggtt  tcacactat  7860
ggctttgtc  gggatgctg  ataaaagtc  ctttccaaa  gtttgtcat  aggggatcg  7920
agaaattaa  tgcaagact  aaggttgtt  acagatatc  ttaatcatt  acagtttgg  7980
aagctgctt  tacatttct  tggaagatg  caaggaatg  taagccaga  aatacagat  8040
cattgtgca  ctgtcaagc  gctaaaata  gtttgggca  cttaattag  gaaaccacc  8100
caaccctta  atttctgac  attttaaat  caatttaat  aaagaaatc  gtactttta  8160
tatttcaca  tcctaaaat  taactatat  gtccatttt  attgatatt  tatgtgtgg  8220
tgtttgttg  agattatct  taatttact  ttaatgttt  tacactgat  tttgtgaaa  8280
tttaaaata  gttggcaac  ggttcctca  cacaatttt  ttagcatta  aaaaaataa  8340
caggtataa  atttctctt  tttctacat  atgttgaac  tatttcatt  tgatttaca  8400
aattttaaa  gtaatatta  tttatatgc  tatgtttat  tccaaaatc  ctacttatg  8460
catcatatc  attaaaaat  gtatttgac  ctaggactg  atttagtaa  agttaaaag  8520
tttcaccct  tttcatgtt  attagggtt  gcactaact  taaaatgtc  cccacggaa  8580
ctactagtc  ctgaaatta  tttacctat  ggtggagaa  ggtgactgg  cagaaaata  8640
gagttagca  taagtagaa  acagcgtac  tgaccacaa  tccatgcag  tagtttgcg  8700
gaaaacggg  gaatctcat  tttctgttt  gtctcttct  actgtgcaa  aaggacaag  8760
aatctttgg  ctatttcta  attcgaatt  tcacaattt  caatcataa  tgtttagca  8820
gactttgta  aattttgat  gttttataa  agagtgaaa  acaaatgca  atgtaaata  8880
agcagccca  actaacgga  tcatcaaat  ttaatatgt  aataaagca  cccatacta  8940
cagattcat  aatgttaat  tgtaaatac  gcagcccac  tgagcagat  cgtcatatg  9000
taagggaat  aattaaaag  aagcaacta  ataaggatg  tcagtgatt  atctgggtt  9060
agaacttgt  tttggaccc  ccaattttt  agtatgtat  ctcacttta  tagttttct  9120
aagaaagca  tcaagaatt  ctcccagaa  atgagtaag  agccatgaa  atatggatg  9180
tgtttacca  acccataga  ccatgaatg  tccaaacgt  tgagtttgt  aaaaaaaat  9240
cattgtagt  atacttgac  atttaaaat  ttaatagaa  ctaaaataa  agtcgctta  9300
aagtcgacg  ggccgc  9316



<210> 350
<211> 1984
<212> PRT
<213> Rattus norvegicus
<308> AAB50403
<400> 350

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
  1               5                  10                  15
Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ser Glu Glu Lys Ala 
             20                  25                  30
Lys Glu His Lys Asp Glu Lys Lys Asp Asp Glu Glu Glu Gly Pro Lys 
         35                  40                  45
Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
     50                  55                  60
Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
 65                  70                  75                  80
Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                 85                  90                  95
Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
             100                105                110
Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
         115                120                125
Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
     130                135                140
Leu Ser Asn Pro Pro Glu Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
 145                150                155                160
Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg Gly Phe 
                 165                170                175
Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
             180                185                190
Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
         195                200                205
Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
     210                215                220
Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
 225                230                235                240
Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                 245                250                255
Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
             260                265                270
His Lys Cys Phe Arg Lys Glu Leu Glu Glu Asn Glu Thr Leu Glu Ser 
         275                280                285
Ile Met Asn Thr Ala Glu Ser Glu Glu Glu Leu Lys Lys Tyr Phe Tyr 
     290                295                300
Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
 305                310                315                320
Ser Gly Gln Cys Pro Glu Gly Tyr Ile Cys Val Lys Ala Gly Arg Asn 
                 325                330                335
Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
             340                345                350
Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
         355                360                365
Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
     370                375                380
Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
 385                390                395                400
Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                 405                410                415
Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
             420                425                430
Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Phe Thr 
         435                440                445
Ser Ile Gly Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
     450                455                460
Thr Ser Arg Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
 465                470                475                480
Lys Lys Lys Lys Gln Lys Met Ser Ser Gly Glu Glu Lys Gly Asp Asp 
                 485                490                495
Glu Lys Leu Ser Lys Ser Gly Ser Glu Glu Ser Ile Arg Lys Lys Ser 
             500                505                510
Phe His Leu Gly Val Glu Gly His His Arg Thr Arg Glu Lys Arg Leu 
         515                520                525
Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser 
     530                535                540
Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly 
 545                550                555                560
Arg Asp Leu Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile 
                 565                570                575
Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg 
             580                585                590
Pro Arg Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro 
         595                600                605
Pro Val Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn 
     610                615                620
Gly Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro Asn 
 625                630                635                640
Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp Asp 
                 645                650                655
Ser Gly Thr Thr Asn Gln Met Arg Lys Lys Arg Leu Ser Ser Ser Tyr 
             660                665                670
Phe Leu Ser Glu Asp Met Leu Asn Asp Pro His Leu Arg Gln Arg Ala 
         675                680                685
Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu 
     690                695                700
Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Thr Phe 
 705                710                715                720
Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Leu Ile 
                 725                730                735
Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
             740                745                750
Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr 
         755                760                765
Glu Glu Phe Lys Asn Val Leu Ala Val Gly Asn Leu Ile Phe Thr Gly 
     770                775                780
Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr 
 785                790                795                800
Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 
                 805                810                815
Leu Ser Leu Ile Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 
             820                825                830
Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
         835                840                845
Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
     850                855                860
Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
 865                870                875                880
Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
                 885                890                895
Lys Ile Asn Val Asp Cys Lys Leu Pro Arg Trp His Met Asn Asp Phe 
             900                905                910
Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
         915                920                925
Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
     930                935                940
Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
 945                950                955                960
Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Thr 
                 965                970                975
Ala Ile Glu Glu Asp Thr Asp Ala Asn Asn Leu Gln Ile Ala Val Ala 
             980                985                990
Arg Ile Lys Arg Gly Ile Asn Tyr Val Lys Gln Thr Leu Arg Glu Phe 
         995                1000                1005
Ile Leu Lys Ser Phe Ser Lys Lys Pro Lys Gly Ser Lys Asp Thr Lys 
     1010                1015                1020
Arg Thr Ala Asp Pro Asn Asn Lys Lys Glu Asn Tyr Ile Ser Asn Arg 
 1025                1030                1035                1040
Thr Leu Ala Glu Met Ser Lys Asp His Asn Phe Leu Lys Glu Lys Asp 
                 1045                1050                1055
Arg Ile Ser Gly Tyr Gly Ser Ser Leu Asp Lys Ser Phe Met Asp Glu 
             1060                1065                1070
Asn Asp Tyr Gln Ser Phe Ile His Asn Pro Ser Leu Thr Val Thr Val 
         1075                1080                1085
Pro Ile Ala Pro Gly Glu Ser Asp Leu Glu Ile Met Asn Thr Glu Glu 
     1090                1095                1100
Leu Ser Ser Asp Ser Asp Ser Asp Tyr Ser Lys Glu Lys Arg Asn Arg 
 1105                1110                1115                1120
Ser Ser Ser Ser Glu Cys Ser Thr Val Asp Asn Pro Leu Pro Gly Glu 
                 1125                1130                1135
Glu Glu Ala Glu Ala Glu Pro Val Asn Ala Asp Glu Pro Glu Ala Cys 
             1140                1145                1150
Phe Thr Asp Gly Cys Val Arg Arg Phe Pro Cys Cys Gln Val Asn Val 
         1155                1160                1165
Asp Ser Gly Lys Gly Lys Val Trp Trp Thr Ile Arg Lys Thr Cys Tyr 
     1170                1175                1180
Arg Ile Val Glu His Ser Trp Phe Glu Ser Phe Ile Val Leu Met Ile 
 1185                1190                1195                1200
Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu Lys 
                 1205                1210                1215
Lys Lys Thr Ile Lys Ile Ile Leu Glu Tyr Ala Asp Lys Ile Phe Thr 
             1220                1225                1230
Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Tyr 
         1235                1240                1245
Lys Thr Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile Val 
     1250                1255                1260
Asp Val Ser Leu Val Thr Leu Val Ala Asn Thr Leu Gly Tyr Ser Asp 
 1265                1270                1275                1280
Leu Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu 
                 1285                1290                1295
Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala Leu 
             1300                1305                1310
Ile Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile 
         1315                1320                1325
Phe Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys 
     1330                1335                1340
Phe Tyr Glu Cys Val Asn Thr Thr Asp Gly Ser Arg Phe Pro Thr Ser 
 1345                1350                1355                1360
Gln Val Ala Asn Arg Ser Glu Cys Phe Ala Leu Met Asn Val Ser Gly 
                 1365                1370                1375
Asn Val Arg Trp Lys Asn Leu Lys Val Asn Phe Asp Asn Val Gly Leu 
             1380                1385                1390
Gly Tyr Leu Ser Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp 
         1395                1400                1405
Ile Met Tyr Ala Ala Val Asp Ser Val Asn Val Asn Glu Gln Pro Lys 
     1410                1415                1420
Tyr Glu Tyr Ser Leu Tyr Met Tyr Ile Tyr Phe Val Ile Phe Ile Ile 
 1425                1430                1435                1440
Phe Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp 
                 1445                1450                1455
Asn Phe Asn Gln Gln Lys Lys Lys Leu Gly Gly Gln Asp Ile Phe Met 
             1460                1465                1470
Thr Glu Glu Gln Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser 
         1475                1480                1485
Lys Lys Pro Gln Lys Pro Ile Pro Arg Pro Gly Asn Lys Phe Gln Gly 
     1490                1495                1500
Cys Ile Phe Asp Leu Val Thr Asn Gln Ala Phe Asp Ile Thr Ile Met 
 1505                1510                1515                1520
Val Leu Ile Cys Leu Asn Met Val Thr Met Met Val Glu Lys Glu Gly 
                 1525                1530                1535
Gln Thr Glu Tyr Met Asp Tyr Val Leu His Trp Ile Asn Met Val Phe 
             1540                1545                1550
Ile Ile Leu Phe Thr Gly Glu Cys Val Leu Lys Leu Ile Ser Leu Arg 
         1555                1560                1565
His Tyr Tyr Phe Thr Val Gly Trp Asn Ile Phe Asp Phe Val Val Val 
     1570                1575                1580
Ile Leu Ser Ile Val Gly Met Phe Leu Ala Glu Met Ile Glu Lys Tyr 
 1585                1590                1595                1600
Phe Val Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly 
                 1605                1610                1615
Arg Ile Leu Arg Leu Ile Lys Gly Ala Lys Gly Ile Arg Thr Leu Leu 
             1620                1625                1630
Phe Ala Leu Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu 
         1635                1640                1645
Leu Phe Leu Val Met Phe Ile Tyr Ala Ile Phe Gly Met Ser Asn Phe 
     1650                1655                1660
Ala Tyr Val Lys Lys Glu Ala Gly Ile Asn Asp Met Phe Asn Phe Glu 
 1665                1670                1675                1680
Thr Phe Gly Asn Ser Met Ile Cys Leu Phe Gln Ile Thr Thr Ser Ala 
                 1685                1690                1695
Gly Trp Asp Gly Leu Leu Ala Pro Ile Leu Asn Ser Ala Pro Pro Asp 
             1700                1705                1710
Cys Asp Pro Lys Lys Val His Pro Gly Ser Ser Val Glu Gly Asp Cys 
         1715                1720                1725
Gly Asn Pro Ser Val Gly Ile Phe Tyr Phe Val Ser Tyr Ile Ile Ile 
     1730                1735                1740
Ser Phe Leu Val Val Val Asn Met Tyr Ile Ala Val Ile Leu Glu Asn 
 1745                1750                1755                1760
Phe Ser Val Ala Thr Glu Glu Ser Thr Glu Pro Leu Ser Glu Asp Asp 
                 1765                1770                1775
Phe Glu Met Phe Tyr Glu Val Trp Glu Lys Phe Asp Pro Asp Ala Thr 
             1780                1785                1790
Gln Phe Ile Glu Phe Cys Lys Leu Ser Asp Phe Ala Ala Ala Leu Asp 
         1795                1800                1805
Pro Pro Leu Leu Ile Ala Lys Pro Asn Lys Val Gln Leu Ile Ala Met 
     1810                1815                1820
Asp Leu Pro Met Val Ser Gly Asp Arg Ile His Cys Leu Asp Ile Leu 
 1825                1830                1835                1840
Phe Ala Phe Thr Lys Arg Val Leu Gly Glu Gly Gly Glu Met Asp Ser 
                 1845                1850                1855
Leu Arg Ser Gln Met Glu Glu Arg Phe Met Ser Ala Asn Pro Ser Lys 
             1860                1865                1870
Val Ser Tyr Glu Pro Ile Thr Thr Thr Leu Lys Arg Lys Gln Glu Glu 
         1875                1880                1885
Val Ser Ala Thr Ile Ile Gln Arg Ala Tyr Arg Arg Tyr Arg Leu Arg 
     1890                1895                1900
Gln His Val Lys Asn Ile Ser Ser Ile Tyr Ile Lys Asp Gly Asp Arg 
 1905                1910                1915                1920
Asp Asp Asp Leu Pro Asn Lys Glu Asp Thr Val Phe Asp Asn Val Asn 
                 1925                1930                1935
Glu Asn Ser Ser Pro Glu Lys Thr Asp Val Thr Ala Ser Thr Ile Ser 
             1940                1945                1950
Pro Pro Ser Tyr Asp Ser Val Thr Lys Pro Asp Gln Glu Lys Tyr Glu 
         1955                1960                1965
Thr Asp Lys Thr Glu Lys Glu Asp Lys Glu Lys Asp Glu Ser Arg Lys 
     1970                1975                1980



<210> 351
<211> 6371
<212> DNA
<213> Homo sapiens
<308> X82835
<400> 351

ctcttatgt  aggagctga  gaggaatta  aatatacag  atgaaaaga  ggcaatgtt  60
cctccccca  gacctcaga  ctttgtcca  ttcacaaaa  agtctcttg  cctcattga  120
caacgcatt  ctgaaagaa  atcaaagga  cccaaagaa  aaaagaaag  tgatgatga  180
gaagcccca  agccaagca  tgacttgga  gctggcaaa  aactgccct  catctatgg  240
gacattcct  ccggcatgg  gtcagagcc  ctggaggac  tggacccct  ctatgcaga  300
aaaaagact  tcatagtat  gaacaaagg  aaaacaatc  tccgtttca  tgccacacc  360
gctttatat  tgctttctc  tttcagtcc  ctaagaaga  tatctatta  gattttagt  420
cactcctta  tcagcatgc  catcatgtg  actattctg  caaactgca  atttatgac  480
atgaataac  cgccggact  gaccaaaaa  gtcgagtac  cttttactg  aatatatac  540
tttgaatca  ttgtaaaaa  ccttgcaag  ggcttctgt  taggagaat  cacttttct  600
cgtgacccg  ggaactggc  ggattttgt  gtcattgtt  ttgcgtatt  aacagaatt  660
gtaaaccta  gcaatgttt  agctcttcg  actttcaga  tattgagag  tttgaaaac  720
atttctgta  tcccaggcc  gaagacaat  gtaggggct  tgatccagt  agtgaagaa  780
ctttctgat  tcatgatcc  gactgtgtt  tgtctgagt  tgtttgcac  aattggact  840
cagctgttc  tgggaaacc  gaagcataa  tgttttcga  attcacttg  aaataatga  900
acattagaa  gcataatga  taccctaga  agtgaagaa  actttagaa  atattttta  960
tacttggaa  gatccaaag  tgctctcct  tgtggtttc  gcacagatt  aggtcagtg  1020
ccagagggg  acacctgtg  gaaaattgg  agaaaccct  attatggct  cacgagctt  1080
gacactttc  gctgggcct  cttagcctt  tttaggcta  tgacccaag  ttactggga  1140
aacctttac  aacagacgc  gcgtgctgc  ggcaaaacc  acatgatct  ctttgtcgt  1200
gtgattttc  tgggctcct  ttatctaat  aacttgatc  tggctgtgg  tgccatggc  1260
tatgaagaa  agaaccagg  aaacattga  gaagctaaa  agaaagaat  agaatttca  1320
cagatgtta  accgtctta  aaaagagca  gaagaagct  aggcaattg  agcggcagc  1380
gctgaatat  caagtatta  gagaagcag  attatgggc  tctcagaga  ttcttctga  1440
acatccaaa  tgagctcta  aagtgctaa  gaaagaaga  acagaagaa  gaaaaagaa  1500
caaaagaag  tctccagtg  agaggaaaa  ggagatgct  agaaattgt  gaaatcaga  1560
tcagaggac  gcatcagaa  aaaaagttt  caccttggt  tcgaagggc  taggcgagc  1620
catgaaaag  ggttgtcta  ccccaatca  tcaccactc  gcattcgtg  ctccttgtt  1680
tctgcaagg  gaagcagca  aacaagtct  tttagtttc  aaggcagag  aagagatat  1740
ggatctgag  ctgaatttg  cgatgatga  cacagcatt  ttggagaca  tgagagcag  1800
aggggctca  tgtttgtgc  ccacagacc  caggagcga  gcagcagta  catcagcca  1860
gccagtagg  ccccaccaa  gctgccggt  aacgggaaa  tgcacagtg  tgtggactg  1920
aacggtgtg  tctccctgg  tgatggacg  tcagccctc  tgctcccca  tggacagct  1980
ctgccagag  gcacgacca  tcaaataca  aagaaaagg  gttgtagtt  ctatctcct  2040
tcagaggat  tgctgaatg  tcccaacct  agacagaga  caatgagta  agcaagcat  2100
ttaacaaac  ctgtggaag  acttgaaga  tccagacaa  aatgtccac  ttggtggta  2160
agatttgca  acaaattct  gatctggaa  tgctctcca  attggataa  attcaaaaa  2220
tgtatctat  ttattgtaa  ggatccttt  gtagatctt  caattacca  ttgcatagt  2280
ttaaacaca  tatttatgg  tatggaaca  cacccaatg  ctgaggaat  caaaaatgt  2340
cttgctata  gaaatttgg  ctttactgg  atctttgca  ctgaaatgg  attaaaact  2400
attgccatg  atccatatg  gtatttcca  gtaggctgg  atatttttg  cagccttat  2460
gtgacttta  gtttagtgg  gctctttct  gcagatgtg  aaggattgt  agttctgcg  2520
tcattcaga  tgctccgag  cttcaagtt  gcaaaatcc  ggccaacat  gaacatgct  2580
attaagatc  ttggtaact  agtaggggc  ctaggtaac  tcaccttag  gttggccat  2640
atcgtcttc  tttttgctg  ggtcggcat  cagctcttt  gtaagagct  caaagaatg  2700
gtctgcaag  tcaatgatg  ctgtacgct  ccacggtgg  acatgaacg  cttcttcca  2760
tccttcctg  ttgtgttcc  cgtgctgtg  ggagagtgg  tagagacca  gtgggactg  2820
atggaggtc  ctggtcaag  tatgtgcct  attgtttac  tgatggtca  ggtcattgg  2880
aacctggtg  tcctaaacc  atttctggc  ttattattg  gctcattta  ttcagacaa  2940
cttacagca  ttgaagaag  ccctgatgc  aacaacctc  agattgcag  gactagaat  3000
aaaaaggga  taaattatg  gaaacaaac  ttacgtgaa  ttattctaa  agcattttc  3060
aaaaagcca  agatttcca  ggagataag  caagcagaa  atctgaata  taagaagga  3120
aactatatt  ctaaccata  acttgctga  atgagcaaa  gtcacaatt  cctcaagga  3180
aaagataaa  tcagtggtt  tggaagcag  gtggacaaa  acttgatgg  agacagtga  3240
ggtcaatca  ttattcaca  tcccagcct  acagtgaca  tgccaattg  acctgggga  3300
tccgatttg  aaaatatga  tgctgagga  cttagcagt  attcggata  tgaatacag  3360
aaagtgaga  taaaccggt  aagctcctc  gagtgcagc  cagttgata  ccctttgcc  3420
ggagaagga  aagaagcag  ggctgaacc  atgaattcc  atgagccag  ggcctgttt  3480
acagatggt  gtgtacgga  gttctcatg  tgccaagtt  acatagagt  agggaaagg  3540
aaaatctgg  ggaacatca  gaaaacctg  tacaagatt  ttgaacaca  ttggtttga  3600
agcttcatt  tcctcatga  cctgctcag  agtggtgcc  tggcttttg  agatattta  3660
attgaaagg  aaaagacca  taagattat  ctggagtat  cagacaaga  cttcactta  3720
atcttcatt  tggaaatgc  tctaaaatg  atagcatat  gttataaaa  atatttcac  3780
aatgcctgg  gttggctgg  tttcctaat  gttgatgtt  ctttggtta  tttagtggc  3840
aacactctt  gctactcag  tcttggccc  attaaatcc  ttcggacac  gagagcttt  3900
agacctcta  gagccttat  tagatttga  ggaatgagg  tcgttgtga  tgcactcat  3960
ggagcaatt  cttccatca  gaatgtgct  cttgtgtgt  ttatattct  gctgatatt  4020
agcatcatg  gagtaaatt  gtttgctgg  aagttctat  agtgtatta  caccacaga  4080
gggtcacgg  ttcctgcaa  tcaagttcc  aatcgttcc  aatgttttg  ccttatgaa  4140
gttagtcaa  atgtgcgat  gaaaaacct  aaagtgaac  ttgataatg  cggacttgg  4200
tacctatct  tgcttcaag  tgcaacttt  aagggatgg  cgattatta  gtatgcagc  4260
gtggattct  ttaatgtag  caagcagcc  aaatatgaa  atagcctct  catgtatat  4320
tattttgtc  tctttatca  ctttgggtc  ttcttcact  tgaacttgt  cattggtgt  4380
atcatagat  atttcaacc  acagaaaaa  aagcttgga  gtcaagaca  ctttatgac  4440
gaagaacag  agaaatact  taatgcaat  aaaaagctg  ggtccaaga  gccacaaaa  4500
ccaattcct  gaccaggga  caaaatcca  ggatgtata  ttgacctag  gacaaatca  4560
gcctttgat  ttagtatca  ggttcttat  tgtctcaac  tggtaacca  gatggtaga  4620
aaggagggt  aaagtcaac  tatgactga  gttttatat  ggataaatg  ggtttttat  4680
atccttttc  ctggagaat  tgtgctaaa  ctgatctcc  tcagacact  ctacttcac  4740
gtaggatgg  atatttttg  ttttgtggt  gtgattatc  ccattgtag  tatgtttct  4800
gctgatttg  ttgaaacgt  ttttgtgtc  cctaccctg  tccgagtga  ccgtcttgc  4860
aggattggc  gaatcctac  tctagtcaa  ggagcaaag  ggatccgca  gctgctctt  4920
gctttgatg  tgtcccttc  tgcgttgtt  aacatcggc  tcctgctct  cctggtcat  4980
ttcatctac  ccatctttg  aatgtccaa  tttgcctat  ttaaaaagg  agatggaat  5040
aatgacatg  tcaattttg  gacctttgg  aacagtatg  tttgcctgt  ccaaattac  5100
acctctgct  gctgggatg  attgctagc  cctattctt  acagtaagc  acccgactg  5160
gacccaaaa  aagttcatc  tggaagttc  gttgaagga  actgtggta  cccatctgt  5220
ggaatattc  actttgtta  ttatatcat  atatccttc  tggttgtgg  gaacatgta  5280
attgcagtc  tactggaga  ttttagtgt  gccactgaa  aaagtactg  acctctgag  5340
gaggatgac  ttgagatgt  ctatgaggt  tgggagaag  ttgatcccg  tgcgaccca  5400
tttatagag  tctctaaac  ctctgattt  gcagctgcc  tggatcctc  tcttctcat  5460
gcaaaaccc  acaaagtcc  gctcattgc  atggatctg  ccatggtta  tggtgaccg  5520
atccattgt  ttgacatct  atttgcttt  acaaagcgt  ttttgggtg  gagtgggga  5580
atggattct  ttcgttcac  gatggaaga  aggttcatg  ctgcaaatc  ttccaaagt  5640
tcctatgaa  ccatcacaa  cacactaaa  cggaaacaa  aggatgtgt  tgctactgt  5700
attcagcgt  cttatagac  ttaccgctt  aggcaaaat  tcaaaaata  atcaagtat  5760
tacataaaa  atggagaca  agatgatga  ttactcaat  aaaaagata  ggcttttga  5820
aatgttaat  agaactcaa  tccagaaaa  acagatgcc  cttcatcca  cacctctcc  5880
ccttcatat  atagtgtaa  aaagccaga  aaagagaaa  atgaacaag  cagaacaga  5940
aaggaagac  aagggaaag  cagcaagga  agcaaaaaa  agagcttca  ttttgatat  6000
ttgtttaca  cctgtgaaa  tgatttatt  gtgttaata  aactctttt  aggaagtct  6060
tgccaaaat  ctttttatc  aaatattct  gaaggcagt  cagtcacta  ctctgattt  6120
ctaagaaag  tgggcagca  tagcagatg  ttatttttg  actgatgat  ctttaagaa  6180
cgtaagaga  ctctgtagg  attattgat  atagcatac  aaagtgatt  attcagttt  6240
ttggttttt  ataaatcag  agaccatgt  gaaaacttt  acatctgcc  tgtcatctt  6300
tcacaggat  gtaattagt  ttgtttccc  tgtaaataa  caacacacg  atacagaaa  6360
aaaaaaaaa  a  6371



<210> 352
<211> 1978
<212> PRT
<213> Homo sapiens
<308> X82835
<400> 352

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
  1               5                  10                  15
Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
             20                  25                  30
Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
         35                  40                  45
Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
     50                  55                  60
Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
 65                  70                  75                  80
Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                 85                  90                  95
Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
             100                105                110
Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
         115                120                125
Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
     130                135                140
Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
 145                150                155                160
Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                 165                170                175
Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
             180                185                190
Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
         195                200                205
Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
     210                215                220
Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
 225                230                235                240
Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                 245                250                255
Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
             260                265                270
His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
         275                280                285
Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
     290                295                300
Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
 305                310                315                320
Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                 325                330                335
Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
             340                345                350
Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
         355                360                365
Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
     370                375                380
Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
 385                390                395                400
Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                 405                410                415
Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
             420                425                430
Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
         435                440                445
Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
     450                455                460
Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
 465                470                475                480
Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                 485                490                495
Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
             500                505                510
Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
         515                520                525
Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
     530                535                540
Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
 545                550                555                560
Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                 565                570                575
Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
             580                585                590
Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
         595                600                605
Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
     610                615                620
Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
 625                630                635                640
Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                 645                650                655
Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
             660                665                670
Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
         675                680                685
Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
     690                695                700
Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
 705                710                715                720
Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                 725                730                735
Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
             740                745                750
Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
         755                760                765
Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
     770                775                780
Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
 785                790                795                800
Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                 805                810                815
Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
             820                825                830
Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
         835                840                845
Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
     850                855                860
Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
 865                870                875                880
Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                 885                890                895
Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
             900                905                910
Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
         915                920                925
Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
     930                935                940
Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
 945                950                955                960
Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                 965                970                975
Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
             980                985                990
Gln Thr Leu Arg Glu Phe Ile Leu Lys Ala Phe Ser Lys Lys Pro Lys 
         995                1000                1005
Ile Ser Arg Glu Ile Arg Gln Ala Glu Asp Leu Asn Thr Lys Lys Glu 
     1010                1015                1020
Asn Tyr Ile Ser Asn His Thr Leu Ala Glu Met Ser Lys Gly His Asn 
 1025                1030                1035                1040
Phe Leu Lys Glu Lys Asp Lys Ile Ser Gly Phe Gly Ser Ser Val Asp 
                 1045                1050                1055
Lys His Leu Met Glu Asp Ser Asp Gly Gln Ser Phe Ile His Asn Pro 
             1060                1065                1070
Ser Leu Thr Val Thr Val Pro Ile Ala Pro Gly Glu Ser Asp Leu Glu 
         1075                1080                1085
Asn Met Asn Ala Glu Glu Leu Ser Ser Asp Ser Asp Ser Glu Tyr Ser 
     1090                1095                1100
Lys Val Arg Leu Asn Arg Ser Ser Ser Ser Glu Cys Ser Thr Val Asp 
 1105                1110                1115                1120
Asn Pro Leu Pro Gly Glu Gly Glu Glu Ala Glu Ala Glu Pro Met Asn 
                 1125                1130                1135
Ser Asp Glu Pro Glu Ala Cys Phe Thr Asp Gly Cys Val Arg Arg Phe 
             1140                1145                1150
Ser Cys Cys Gln Val Asn Ile Glu Ser Gly Lys Gly Lys Ile Trp Trp 
         1155                1160                1165
Asn Ile Arg Lys Thr Cys Tyr Lys Ile Val Glu His Ser Trp Phe Glu 
     1170                1175                1180
Ser Phe Ile Val Leu Met Ile Leu Leu Ser Ser Gly Ala Leu Ala Phe 
 1185                1190                1195                1200
Glu Asp Ile Tyr Ile Glu Arg Lys Lys Thr Ile Lys Ile Ile Leu Glu 
                 1205                1210                1215
Tyr Ala Asp Lys Ile Phe Thr Tyr Ile Phe Ile Leu Glu Met Leu Leu 
             1220                1225                1230
Lys Trp Ile Ala Tyr Gly Tyr Lys Thr Tyr Phe Thr Asn Ala Trp Cys 
         1235                1240                1245
Trp Leu Asp Phe Leu Ile Val Asp Val Ser Leu Val Thr Leu Val Ala 
     1250                1255                1260
Asn Thr Leu Gly Tyr Ser Asp Leu Gly Pro Ile Lys Ser Leu Arg Thr 
 1265                1270                1275                1280
Leu Arg Ala Leu Arg Pro Leu Arg Ala Leu Ser Arg Phe Glu Gly Met 
                 1285                1290                1295
Arg Val Val Val Asn Ala Leu Ile Gly Ala Ile Pro Ser Ile Met Asn 
             1300                1305                1310
Val Leu Leu Val Cys Leu Ile Phe Trp Leu Ile Phe Ser Ile Met Gly 
         1315                1320                1325
Val Asn Leu Phe Ala Gly Lys Phe Tyr Glu Cys Ile Asn Thr Thr Asp 
     1330                1335                1340
Gly Ser Arg Phe Pro Ala Ser Gln Val Pro Asn Arg Ser Glu Cys Phe 
 1345                1350                1355                1360
Ala Leu Met Asn Val Ser Gln Asn Val Arg Trp Lys Asn Leu Lys Val 
                 1365                1370                1375
Asn Phe Asp Asn Val Gly Leu Gly Tyr Leu Ser Leu Leu Gln Val Ala 
             1380                1385                1390
Thr Phe Lys Gly Trp Thr Ile Ile Met Tyr Ala Ala Val Asp Ser Val 
         1395                1400                1405
Asn Val Asp Lys Gln Pro Lys Tyr Glu Tyr Ser Leu Tyr Met Tyr Ile 
     1410                1415                1420
Tyr Phe Val Val Phe Ile Ile Phe Gly Ser Phe Phe Thr Leu Asn Leu 
 1425                1430                1435                1440
Phe Ile Gly Val Ile Ile Asp Asn Phe Asn Gln Gln Lys Lys Lys Leu 
                 1445                1450                1455
Gly Gly Gln Asp Ile Phe Met Thr Glu Glu Gln Lys Lys Tyr Tyr Asn 
             1460                1465                1470
Ala Met Lys Lys Leu Gly Ser Lys Lys Pro Gln Lys Pro Ile Pro Arg 
         1475                1480                1485
Pro Gly Asn Lys Ile Gln Gly Cys Ile Phe Asp Leu Val Thr Asn Gln 
     1490                1495                1500
Ala Phe Asp Ile Ser Ile Met Val Leu Ile Cys Leu Asn Met Val Thr 
 1505                1510                1515                1520
Met Met Val Glu Lys Glu Gly Gln Ser Gln His Met Thr Glu Val Leu 
                 1525                1530                1535
Tyr Trp Ile Asn Val Val Phe Ile Ile Leu Phe Thr Gly Glu Cys Val 
             1540                1545                1550
Leu Lys Leu Ile Ser Leu Arg His Tyr Tyr Phe Thr Val Gly Trp Asn 
         1555                1560                1565
Ile Phe Asp Phe Val Val Val Ile Ile Ser Ile Val Gly Met Phe Leu 
     1570                1575                1580
Ala Asp Leu Ile Glu Thr Tyr Phe Val Ser Pro Thr Leu Phe Arg Val 
 1585                1590                1595                1600
Ile Arg Leu Ala Arg Ile Gly Arg Ile Leu Arg Leu Val Lys Gly Ala 
                 1605                1610                1615
Lys Gly Ile Arg Thr Leu Leu Phe Ala Leu Met Met Ser Leu Pro Ala 
             1620                1625                1630
Leu Phe Asn Ile Gly Leu Leu Leu Phe Leu Val Met Phe Ile Tyr Ala 
         1635                1640                1645
Ile Phe Gly Met Ser Asn Phe Ala Tyr Val Lys Lys Glu Asp Gly Ile 
     1650                1655                1660
Asn Asp Met Phe Asn Phe Glu Thr Phe Gly Asn Ser Met Ile Cys Leu 
 1665                1670                1675                1680
Phe Gln Ile Thr Thr Ser Ala Gly Trp Asp Gly Leu Leu Ala Pro Ile 
                 1685                1690                1695
Leu Asn Ser Lys Pro Pro Asp Cys Asp Pro Lys Lys Val His Pro Gly 
             1700                1705                1710
Ser Ser Val Glu Gly Asp Cys Gly Asn Pro Ser Val Gly Ile Phe Tyr 
         1715                1720                1725
Phe Val Ser Tyr Ile Ile Ile Ser Phe Leu Val Val Val Asn Met Tyr 
     1730                1735                1740
Ile Ala Val Ile Leu Glu Asn Phe Ser Val Ala Thr Glu Glu Ser Thr 
 1745                1750                1755                1760
Glu Pro Leu Ser Glu Asp Asp Phe Glu Met Phe Tyr Glu Val Trp Glu 
                 1765                1770                1775
Lys Phe Asp Pro Asp Ala Thr Gln Phe Ile Glu Phe Ser Lys Leu Ser 
             1780                1785                1790
Asp Phe Ala Ala Ala Leu Asp Pro Pro Leu Leu Ile Ala Lys Pro Asn 
         1795                1800                1805
Lys Val Gln Leu Ile Ala Met Asp Leu Pro Met Val Ser Gly Asp Arg 
     1810                1815                1820
Ile His Cys Leu Asp Ile Leu Phe Ala Phe Thr Lys Arg Val Leu Gly 
 1825                1830                1835                1840
Glu Ser Gly Glu Met Asp Ser Leu Arg Ser Gln Met Glu Glu Arg Phe 
                 1845                1850                1855
Met Ser Ala Asn Pro Ser Lys Val Ser Tyr Glu Pro Ile Thr Thr Thr 
             1860                1865                1870
Leu Lys Arg Lys Gln Glu Asp Val Ser Ala Thr Val Ile Gln Arg Ala 
         1875                1880                1885
Tyr Arg Arg Tyr Arg Leu Arg Gln Asn Val Lys Asn Ile Ser Ser Ile 
     1890                1895                1900
Tyr Ile Lys Asp Gly Asp Arg Asp Asp Asp Leu Leu Asn Lys Lys Asp 
 1905                1910                1915                1920
Met Ala Phe Asp Asn Val Asn Glu Asn Ser Ser Pro Glu Lys Thr Asp 
                 1925                1930                1935
Ala Thr Ser Ser Thr Thr Ser Pro Pro Ser Tyr Asp Ser Val Thr Lys 
             1940                1945                1950
Pro Asp Lys Glu Lys Tyr Glu Gln Asp Arg Thr Glu Lys Glu Asp Lys 
         1955                1960                1965
Gly Lys Asp Ser Lys Glu Ser Lys Lys Ter 
     1970                1975



<210> 353
<211> 9316
<212> DNA
<213> Rattus norvegicus
<308> AF000368
<400> 353

atggcgatg  tgcctcctc  aggacctca  agtttcgtt  acttcacaa  acagtccct  60
gccctcatt  aacagcgta  ttctgaaga  aaagccaag  aacacaaag  cgaaaagaa  120
gatgatgag  aagaaggcc  caagcccag  agtgacttg  aagctggga  acagctccc  180
ttcatctat  gagacattc  ccctggaat  gtgtcagag  ccctggagg  cctggaccc  240
tactatgct  acaaaaaaa  ttttatagt  ttgaacaaa  ggaaagcaa  cttccgttt  300
aacgccacc  ctgctttgt  catgctgtc  cccttcagt  ctctaagaa  aatatctat  360
aagatctta  tgcactcct  attcagcat  ctaatcatg  gcacaattc  gacgaactg  420
atattcatg  ccttgagca  ccctccaga  tggaccaaa  atgtagagt  cacttttac  480
gggatatat  cttttgaat  actcataaa  atccttgca  gaggctttt  cgtgggaga  540
ttcaccttc  tccgtgacc  ttggaactg  ctggacttt  ttgtcattg  ttttgcgta  600
ttaacagaa  ttgtaaacc  aggcaatgt  tcagctctt  gaactttca  agtcttgag  660
gctttgaaa  ctatttctg  aatcccagg  ctaaagacc  tcgtggggg  cctgatcca  720
tcagtgaag  agctctctg  cgtcatgat  ctcactgtg  tctgtctca  tgtgtttgc  780
ctaattgga  tacagctgt  tatgggcaa  ttgaagcat  aatgtttca  gaaggaact  840
gaagagaat  aaacattag  aagtatcat  aatactgct  agagtgaag  agaattgaa  900
aaatatttt  attacttgg  gggatccaa  gatgctcta  tctgcggct  cagcacaga  960
tcagggcag  gtccagaag  ctacatctg  gtgaaggct  gcagaaacc  ggattatgg  1020
tacacgagc  ttgacacat  cagctgggc  ttcttggcc  tgtttcggc  aatgactca  1080
gactactgg  agaaccttt  ccaacagac  ctgcgtgct  ctggcaaaa  ctacatgat  1140
ttctttgtc  tggttattt  tctgggctc  ttttacctg  taaacttga  cctggctgt  1200
gtagccatg  cgtatgagg  acagaacca  gccaacatc  aagaagcta  acagaaaga  1260
ttagaattt  agcagatgt  agaccgact  aaaaaggag  aggaagaag  tgaggcgat  1320
gctgcagct  ctgctgagt  cacgagtat  gggcggagc  ggatcatgg  actctctga  1380
agctcttca  aaacctcca  gctgagctc  aagagtgcc  aggagagaa  aaaccgaag  1440
aagaaaaag  aacagaaga  gtccagtgg  gaggaaaag  gtgacgatg  gaagctgtc  1500
aagtcagga  cagaggaaa  catccgaaa  aaaagtttc  atctcggtg  ggaagggca  1560
caccggacc  gggaaaaga  gctgtccac  cccaaccag  cgccactca  cattcgcgg  1620
tccctgttt  ctgccaggc  cagcagcag  acgagtctc  tcagtttta  ggggcgagg  1680
agagatctg  gatctgaga  agaattcgc  gatgatgag  atagcattt  tggagacaa  1740
gagagcaga  ggggttcac  attcgtacc  catagaccc  gggagcggc  cagcagtaa  1800
atcagtcag  ccagtaggt  cccgccagt  ctaccggtg  acgggaaga  gcacagtgc  1860
gtggactgc  atggcgtcg  gtcgcttgt  gatggaccc  cagccctca  gctccccaa  1920
ggacagctt  ttccagagg  gataataga  aaggcaact  ccgacgaca  cggcacgac  1980
aatcagatg  gcaaaaaaa  gctctctag  tcttacttc  tgtctgagg  catgctgaa  2040
gacccgcat  tcaggcaaa  ggccatgag  agggcgagc  tactgacca  cactgtgga  2100
gaacttgaa  aatctagac  aaaatgtcc  ccatggtgg  acagatttg  tcacacatt  2160
ttaatctgg  attgctctc  atattggat  aaattcaaa  agctcatct  ttttattgt  2220
atggatcct  ttgtagatc  tgcaattac  atttgcata  ttttaaaca  cttatttat  2280
gctatggag  accacccaa  gactgaaga  ttcaaaaat  tccttgcag  ggggaactt  2340
atctttaca  ggatcttcg  agctgaaat  gtactgaag  taatagcca  ggaccccta  2400
gagtatttc  aagtagggt  gaatatttt  gacagccta  ttgtgacgc  gagtttgat  2460
gagcttttc  tagcagatg  ggaaggatt  tcagttctg  ggtcattca  attgctccg  2520
gtcttcaag  tggcaaagt  ctggcccac  ctgaacatg  tcattaaga  catcggcaa  2580
tcggtgggc  cactgggca  cctgaccct  gtgctggcc  tcatcgtct  catttttgc  2640
gtggtcggc  tgcagctgt  tggaaagag  tacaaggag  gtgtctgca  gatcaatgt  2700
gactgcaag  tgccgcgct  gcacatgaa  gacttcttc  actccttcc  catcgtgtt  2760
cgagtgctg  gtggggagt  gatagagac  atgtgggac  gcatggagg  cgcgggcca  2820
accatgtgc  ttattgttt  catgatggt  atggtgatt  ggaaccttg  ggtcctgaa  2880
ctgtttctg  ctcttttgc  gagttcctt  agttctgac  atcttacag  aattgagga  2940
gacaccgat  caaacaacc  ccagatcgc  gtggccaga  ttaagaggg  aatcaatta  3000
gtgaaacag  ccctgcgtg  attcattct  aaatcattt  ccaaaaagc  aaagggctc  3060
aaggacaca  aacgaacag  agatcccaa  aacaagaaa  aaaactata  ttcaaaccg  3120
acccttgcg  agatgagca  ggatcacaa  ttcctcaaa  aaaaggata  gatcagtgg  3180
tatggcagc  gtctagaca  aagctttat  gatgaaaat  attaccagt  ctttatcca  3240
aaccccagc  tcacagtga  agtgccaat  gcacctggg  agtctgatt  ggagattat  3300
aacacagaa  agcttagca  tgactcaga  agtgactac  gcaaagaga  acggaaccg  3360
tcaagctct  ctgagtgca  cactgttga  aaccctctg  caggagaag  ggaggctga  3420
gcagagccc  taaacgcag  tgagcctga  gcctgcttt  cagatggtt  tgtgaggag  3480
tttccatgc  gccaagtta  tgtagactc  gggaaaggg  aagtttggt  gaccatcag  3540
aagacgtgc  acaggatag  tgaacacag  tggtttgaa  gcttcatcg  tctcatgat  3600
ctgctcagc  gtggagctc  ggcttttga  gatatctat  ttgaaaaga  aaagaccat  3660
aagattatc  tggagtatg  tgacaagat  ttcacctac  tcttcattc  ggaaatgct  3720
ctaaaatgg  tcgcatatg  gtataaaac  tatttcact  atgcctggt  ttggctgga  3780
ttcttaatt  ttgatgtgt  tctagttac  ttagtagcc  acactcttg  ctactcaga  3840
cttggcccc  ttaaatctc  acggacact  agggcccta  gacccctaa  agccttgtc  3900
agatttgaa  gaatgaggg  agtggtcaa  gcactcata  gagcaatcc  ttccatcat  3960
aacgtgctt  tcgtgtgcc  tatattctg  ctaatattt  gcatcatgg  agtcaatct  4020
tttgctggc  agttctatg  gtgtgtcaa  accaccgat  ggtcacgat  tcctacatc  4080
caagttgca  accgttctg  gtgttttgc  ctgatgaac  ttagtggaa  tgtgcgatg  4140
aaaaacctg  aagtaaact  cgacaacgt  gggcttggt  acctgtcgc  gcttcaagt  4200
gcaacattc  agggctgga  ggatattat  tatgcagca  ttgactctg  taatgtaaa  4260
gaacagccg  aatacgaat  cagtctcta  atgtacatt  actttgtca  cttcatcat  4320
ttcggctca  tcttcacgt  gaacctgtt  attggtgtc  tcatagata  tttcaacca  4380
cagaaaaaa  agcttggag  tcaagatat  tttatgaca  aagaacaga  gaaatacta  4440
aatgcaatg  agaagcttg  gtccaaaaa  ccacaaaaa  caattccaa  gccagggaa  4500
aaattccaa  gatgtatat  tgacttagt  acaaaccaa  cttttgata  caccatcat  4560
gttcttata  gcctcaaca  ggtaaccat  atggtagaa  aagaggggc  aactgagta  4620
atggattat  ttttacact  gatcaacat  gtcttcatt  tcctgttca  tggggagtg  4680
gtgctgaag  taatctccc  cagacatta  tacttcact  tgggttgga  catttttga  4740
tttgtggta  tgatcctct  cattgtagg  atgtttctc  ctgagatga  agagaagta  4800
ttcgtgtcc  ctaccctgt  ccgagtcat  cgcctggcc  ggattggac  aatcctacg  4860
ctgatcaaa  gcgccaagg  gatccgcac  ctgctcttt  ctttgatga  gtcccttcc  4920
gcgctgttc  acatcggcc  cctgctttt  ctggtcatg  tcatctacg  catctttgg  4980
atgtccaac  ttgcctacg  taaaaagga  gctggaatt  atgacatgt  caactttga  5040
acttttggc  acagcatga  ctgcttgtt  caaatcacc  cctctgccg  ctgggacgg  5100
ctgctggcc  ccatcctca  cagcgcacc  cccgactgt  accctaaaa  agttcaccc  5160
ggaagttca  tggaagggg  ctgtgggaa  ccatccgtg  ggatttttt  ctttgtcag  5220
tacatcatc  tatccttcc  ggtggtggt  aacatgtac  tcgctgtca  cctggagaa  5280
ttcagcgtc  ccaccgaag  gagcactga  cctctgagt  aggacgact  tgagatgtt  5340
tacgaggtc  gggagaagt  cgaccctga  gccactcag  tcatagagt  ctgcaagct  5400
tctgacttt  cagctgccc  ggatcctcc  ctcctcatc  caaagccaa  caaagtcca  5460
ctcattgcc  tggacctgc  catggtgag  ggagaccgc  tccactgcc  ggacatctt  5520
tttgctttt  caaagcggg  cctgggtga  ggtggagag  tggattctc  tcgttcaca  5580
atggaagaa  ggttcatgt  agccaatcc  tctaaagtg  cctatgaac  catcacgac  5640
acactgaag  gaaaacaag  ggaggtgtc  gcgactatc  ttcagcgtg  ttacagacg  5700
tatcgcctc  gacaacacg  caagaatat  tcgagtata  acataaaag  tggagacag  5760
gatgatgat  tgcccaata  agaagatac  gtttttgat  acgtgaacg  gaactcaag  5820
ccggaaaag  cagatgtaa  tgcctcaac  atctcgcca  cttcctatg  cagtgtcac  5880
aagccagat  aagagaaat  tgaaacaga  aaaacagag  aggaagaca  agagaaaga  5940
gaaagcagg  aatagagct  tggttttga  acactgttg  cagcctgtg  aggttgact  6000
actcgtgtt  gtaagactc  tttacggag  tctatgcca  actcttttt  tcaaaaaat  6060
ctcaaaggc  gcacagcca  tagctctga  ccaacgagg  agagggcag  atttacaca  6120
ggctatgtt  tgctttggt  aatgattct  ttaagattt  agagtgtaa  tctgaaggg  6180
agagccatc  ctgcattca  gggtgactt  gacattcta  aaatcagaa  accaagtca  6240
acattttct  atttgcctc  atgtctttt  tctaggttc  aaataaatg  gcacccatg  6300
gaatctaga  atccaggca  acatgcaca  atgcacaca  tcacaaata  aaacaggat  6360
ggctacgat  tcaaattct  tgtaaatgt  tcactttgg  ttgcaatga  atttccttg  6420
aaaggaaat  ggattagtg  cgaaggttt  gtcaaaaca  cttattatt  gggaatcag  6480
atctttaat  taaaaagaa  tcagtttat  tttttgagg  gctgaaact  atcctacat  6540
gcgtcaaaa  caacttata  gaatctata  gatgtcatg  aattgaaaa  cgtatgtgg  6600
ctatttatt  aagaaatca  tttcatttg  atattagca  cattcacct  gatttatgg  6660
catcttgga  attgtgtgg  cacatgatg  tcccacaaa  ttgtttagc  gaaacttca  6720
gcacacatc  cagagaaca  ctacccagt  ttacgctcc  ccctgttca  acaataacc  6780
cagaccttt  aacattatt  ggaatataa  tattaggtt  ctcaatata  acatgtgaa  6840
attaacaga  aagttaatt  acagcgttt  acttactaa  gtctatcca  tctagtttg  6900
acaatgaga  agctctcac  tcttacagc  agttgccac  tttctcttc  tacgaagct  6960
cggtttgtc  gactttatc  ctaagcaaa  tctatgttt  ctttttaat  aaacgtatc  7020
tgaaaagcg  ttagctact  gatacttta  tgcttgttt  agcagatga  tggagcatg  7080
tatgtaccc  atcttttaa  atacaatcc  taatgtgtt  ggcagcttc  caagttaca  7140
ggaacgccg  gcttttaat  tctctccgt  caccaggtg  tttgtatga  tgaaatgac  7200
ttcaaagag  gagtctcat  ggcttgctt  attaccaac  actttccta  atgaggaac  7260
aatcctctg  agcactatt  tatcccctt  taaataaca  agatgtcac  tcgttctta  7320
tattctaat  catggtgtg  catatattt  gcattgatc  gtaaagtag  ctgggataa  7380
cattttaag  gcatataca  tttgaggta  gtgaagtta  tctaccaag  attagaaac  7440
tactccaag  ttttaaagt  cttgataaa  atgaatgac  ctgacaaat  ctctcataa  7500
tttattcca  caatgtgaa  tctttcctc  aacacttta  ccttgcaga  aagaaagaa  7560
aaacaaaga  aagcccatg  gccatgtaa  caaaggggc  ttatctaga  gattctgag  7620
gaacctttg  agtaaatat  taaaacata  ttcctcagt  tgcctttga  attaaaaag  7680
aacacaaaa  tatggattt  ataagtcat  aaaacacat  ctttatttc  ggcccagtt  7740
aaaggaaag  attaaaaat  cctatagag  gggggggac  gagagagaa  gagggagag  7800
agaaacaaa  tactaggga  aaaaagatt  gacagaata  gtccaggtt  tcacactat  7860
ggctttgtc  gggatgctg  ataaaagtc  ctttccaaa  gtttgtcat  aggggatcg  7920
agaaattaa  tgcaagact  aaggttgtt  acagatatc  ttaatcatt  acagtttgg  7980
aagctgctt  tacatttct  tggaagatg  caaggaatg  taagccaga  aatacagat  8040
cattgtgca  ctgtcaagc  gctaaaata  gtttgggca  cttaattag  gaaaccacc  8100
caaccctta  atttctgac  attttaaat  caatttaat  aaagaaatc  gtactttta  8160
tatttcaca  tcctaaaat  taactatat  gtccatttt  attgatatt  tatgtgtgg  8220
tgtttgttg  agattatct  taatttact  ttaatgttt  tacactgat  tttgtgaaa  8280
tttaaaata  gttggcaac  ggttcctca  cacaatttt  ttagcatta  aaaaaataa  8340
caggtataa  atttctctt  tttctacat  atgttgaac  tatttcatt  tgatttaca  8400
aattttaaa  gtaatatta  tttatatgc  tatgtttat  tccaaaatc  ctacttatg  8460
catcatatc  attaaaaat  gtatttgac  ctaggactg  atttagtaa  agttaaaag  8520
tttcaccct  tttcatgtt  attagggtt  gcactaact  taaaatgtc  cccacggaa  8580
ctactagtc  ctgaaatta  tttacctat  ggtggagaa  ggtgactgg  cagaaaata  8640
gagttagca  taagtagaa  acagcgtac  tgaccacaa  tccatgcag  tagtttgcg  8700
gaaaacggg  gaatctcat  tttctgttt  gtctcttct  actgtgcaa  aaggacaag  8760
aatctttgg  ctatttcta  attcgaatt  tcacaattt  caatcataa  tgtttagca  8820
gactttgta  aattttgat  gttttataa  agagtgaaa  acaaatgca  atgtaaata  8880
agcagccca  actaacgga  tcatcaaat  ttaatatgt  aataaagca  cccatacta  8940
cagattcat  aatgttaat  tgtaaatac  gcagcccac  tgagcagat  cgtcatatg  9000
taagggaat  aattaaaag  aagcaacta  ataaggatg  tcagtgatt  atctgggtt  9060
agaacttgt  tttggaccc  ccaattttt  agtatgtat  ctcacttta  tagttttct  9120
aagaaagca  tcaagaatt  ctcccagaa  atgagtaag  agccatgaa  atatggatg  9180
tgtttacca  acccataga  ccatgaatg  tccaaacgt  tgagtttgt  aaaaaaaat  9240
cattgtagt  atacttgac  atttaaaat  ttaatagaa  ctaaaataa  agtcgctta  9300
aagtcgacg  ggccgc  9316



<210> 354
<211> 1984
<212> PRT
<213> Rattus norvegicus
<308> AAB50403
<400> 354

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
  1               5                  10                  15
Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ser Glu Glu Lys Ala 
             20                  25                  30
Lys Glu His Lys Asp Glu Lys Lys Asp Asp Glu Glu Glu Gly Pro Lys 
         35                  40                  45
Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
     50                  55                  60
Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
 65                  70                  75                  80
Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                 85                  90                  95
Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
             100                105                110
Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
         115                120                125
Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
     130                135                140
Leu Ser Asn Pro Pro Glu Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
 145                150                155                160
Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg Gly Phe 
                 165                170                175
Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
             180                185                190
Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
         195                200                205
Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
     210                215                220
Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
 225                230                235                240
Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                 245                250                255
Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
             260                265                270
His Lys Cys Phe Arg Lys Glu Leu Glu Glu Asn Glu Thr Leu Glu Ser 
         275                280                285
Ile Met Asn Thr Ala Glu Ser Glu Glu Glu Leu Lys Lys Tyr Phe Tyr 
     290                295                300
Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
 305                310                315                320
Ser Gly Gln Cys Pro Glu Gly Tyr Ile Cys Val Lys Ala Gly Arg Asn 
                 325                330                335
Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
             340                345                350
Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
         355                360                365
Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
     370                375                380
Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
 385                390                395                400
Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                 405                410                415
Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
             420                425                430
Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Phe Thr 
         435                440                445
Ser Ile Gly Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
     450                455                460
Thr Ser Arg Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
 465                470                475                480
Lys Lys Lys Lys Gln Lys Met Ser Ser Gly Glu Glu Lys Gly Asp Asp 
                 485                490                495
Glu Lys Leu Ser Lys Ser Gly Ser Glu Glu Ser Ile Arg Lys Lys Ser 
             500                505                510
Phe His Leu Gly Val Glu Gly His His Arg Thr Arg Glu Lys Arg Leu 
         515                520                525
Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser 
     530                535                540
Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly 
 545                550                555                560
Arg Asp Leu Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile 
                 565                570                575
Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg 
             580                585                590
Pro Arg Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro 
         595                600                605
Pro Val Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn 
     610                615                620
Gly Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro Asn 
 625                630                635                640
Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp Asp 
                 645                650                655
Ser Gly Thr Thr Asn Gln Met Arg Lys Lys Arg Leu Ser Ser Ser Tyr 
             660                665                670
Phe Leu Ser Glu Asp Met Leu Asn Asp Pro His Leu Arg Gln Arg Ala 
         675                680                685
Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu 
     690                695                700
Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Thr Phe 
 705                710                715                720
Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Leu Ile 
                 725                730                735
Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
             740                745                750
Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr 
         755                760                765
Glu Glu Phe Lys Asn Val Leu Ala Val Gly Asn Leu Ile Phe Thr Gly 
     770                775                780
Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr 
 785                790                795                800
Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 
                 805                810                815
Leu Ser Leu Ile Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 
             820                825                830
Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
         835                840                845
Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
     850                855                860
Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
 865                870                875                880
Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
                 885                890                895
Lys Ile Asn Val Asp Cys Lys Leu Pro Arg Trp His Met Asn Asp Phe 
             900                905                910
Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
         915                920                925
Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
     930                935                940
Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
 945                950                955                960
Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Thr 
                 965                970                975
Ala Ile Glu Glu Asp Thr Asp Ala Asn Asn Leu Gln Ile Ala Val Ala 
             980                985                990
Arg Ile Lys Arg Gly Ile Asn Tyr Val Lys Gln Thr Leu Arg Glu Phe 
         995                1000                1005
Ile Leu Lys Ser Phe Ser Lys Lys Pro Lys Gly Ser Lys Asp Thr Lys 
     1010                1015                1020
Arg Thr Ala Asp Pro Asn Asn Lys Lys Glu Asn Tyr Ile Ser Asn Arg 
 1025                1030                1035                1040
Thr Leu Ala Glu Met Ser Lys Asp His Asn Phe Leu Lys Glu Lys Asp 
                 1045                1050                1055
Arg Ile Ser Gly Tyr Gly Ser Ser Leu Asp Lys Ser Phe Met Asp Glu 
             1060                1065                1070
Asn Asp Tyr Gln Ser Phe Ile His Asn Pro Ser Leu Thr Val Thr Val 
         1075                1080                1085
Pro Ile Ala Pro Gly Glu Ser Asp Leu Glu Ile Met Asn Thr Glu Glu 
     1090                1095                1100
Leu Ser Ser Asp Ser Asp Ser Asp Tyr Ser Lys Glu Lys Arg Asn Arg 
 1105                1110                1115                1120
Ser Ser Ser Ser Glu Cys Ser Thr Val Asp Asn Pro Leu Pro Gly Glu 
                 1125                1130                1135
Glu Glu Ala Glu Ala Glu Pro Val Asn Ala Asp Glu Pro Glu Ala Cys 
             1140                1145                1150
Phe Thr Asp Gly Cys Val Arg Arg Phe Pro Cys Cys Gln Val Asn Val 
         1155                1160                1165
Asp Ser Gly Lys Gly Lys Val Trp Trp Thr Ile Arg Lys Thr Cys Tyr 
     1170                1175                1180
Arg Ile Val Glu His Ser Trp Phe Glu Ser Phe Ile Val Leu Met Ile 
 1185                1190                1195                1200
Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu Lys 
                 1205                1210                1215
Lys Lys Thr Ile Lys Ile Ile Leu Glu Tyr Ala Asp Lys Ile Phe Thr 
             1220                1225                1230
Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Tyr 
         1235                1240                1245
Lys Thr Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile Val 
     1250                1255                1260
Asp Val Ser Leu Val Thr Leu Val Ala Asn Thr Leu Gly Tyr Ser Asp 
 1265                1270                1275                1280
Leu Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu 
                 1285                1290                1295
Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala Leu 
             1300                1305                1310
Ile Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile 
         1315                1320                1325
Phe Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys 
     1330                1335                1340
Phe Tyr Glu Cys Val Asn Thr Thr Asp Gly Ser Arg Phe Pro Thr Ser 
 1345                1350                1355                1360
Gln Val Ala Asn Arg Ser Glu Cys Phe Ala Leu Met Asn Val Ser Gly 
                 1365                1370                1375
Asn Val Arg Trp Lys Asn Leu Lys Val Asn Phe Asp Asn Val Gly Leu 
             1380                1385                1390
Gly Tyr Leu Ser Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp 
         1395                1400                1405
Ile Met Tyr Ala Ala Val Asp Ser Val Asn Val Asn Glu Gln Pro Lys 
     1410                1415                1420
Tyr Glu Tyr Ser Leu Tyr Met Tyr Ile Tyr Phe Val Ile Phe Ile Ile 
 1425                1430                1435                1440
Phe Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp 
                 1445                1450                1455
Asn Phe Asn Gln Gln Lys Lys Lys Leu Gly Gly Gln Asp Ile Phe Met 
             1460                1465                1470
Thr Glu Glu Gln Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser 
         1475                1480                1485
Lys Lys Pro Gln Lys Pro Ile Pro Arg Pro Gly Asn Lys Phe Gln Gly 
     1490                1495                1500
Cys Ile Phe Asp Leu Val Thr Asn Gln Ala Phe Asp Ile Thr Ile Met 
 1505                1510                1515                1520
Val Leu Ile Cys Leu Asn Met Val Thr Met Met Val Glu Lys Glu Gly 
                 1525                1530                1535
Gln Thr Glu Tyr Met Asp Tyr Val Leu His Trp Ile Asn Met Val Phe 
             1540                1545                1550
Ile Ile Leu Phe Thr Gly Glu Cys Val Leu Lys Leu Ile Ser Leu Arg 
         1555                1560                1565
His Tyr Tyr Phe Thr Val Gly Trp Asn Ile Phe Asp Phe Val Val Val 
     1570                1575                1580
Ile Leu Ser Ile Val Gly Met Phe Leu Ala Glu Met Ile Glu Lys Tyr 
 1585                1590                1595                1600
Phe Val Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly 
                 1605                1610                1615
Arg Ile Leu Arg Leu Ile Lys Gly Ala Lys Gly Ile Arg Thr Leu Leu 
             1620                1625                1630
Phe Ala Leu Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu 
         1635                1640                1645
Leu Phe Leu Val Met Phe Ile Tyr Ala Ile Phe Gly Met Ser Asn Phe 
     1650                1655                1660
Ala Tyr Val Lys Lys Glu Ala Gly Ile Asn Asp Met Phe Asn Phe Glu 
 1665                1670                1675                1680
Thr Phe Gly Asn Ser Met Ile Cys Leu Phe Gln Ile Thr Thr Ser Ala 
                 1685                1690                1695
Gly Trp Asp Gly Leu Leu Ala Pro Ile Leu Asn Ser Ala Pro Pro Asp 
             1700                1705                1710
Cys Asp Pro Lys Lys Val His Pro Gly Ser Ser Val Glu Gly Asp Cys 
         1715                1720                1725
Gly Asn Pro Ser Val Gly Ile Phe Tyr Phe Val Ser Tyr Ile Ile Ile 
     1730                1735                1740
Ser Phe Leu Val Val Val Asn Met Tyr Ile Ala Val Ile Leu Glu Asn 
 1745                1750                1755                1760
Phe Ser Val Ala Thr Glu Glu Ser Thr Glu Pro Leu Ser Glu Asp Asp 
                 1765                1770                1775
Phe Glu Met Phe Tyr Glu Val Trp Glu Lys Phe Asp Pro Asp Ala Thr 
             1780                1785                1790
Gln Phe Ile Glu Phe Cys Lys Leu Ser Asp Phe Ala Ala Ala Leu Asp 
         1795                1800                1805
Pro Pro Leu Leu Ile Ala Lys Pro Asn Lys Val Gln Leu Ile Ala Met 
     1810                1815                1820
Asp Leu Pro Met Val Ser Gly Asp Arg Ile His Cys Leu Asp Ile Leu 
 1825                1830                1835                1840
Phe Ala Phe Thr Lys Arg Val Leu Gly Glu Gly Gly Glu Met Asp Ser 
                 1845                1850                1855
Leu Arg Ser Gln Met Glu Glu Arg Phe Met Ser Ala Asn Pro Ser Lys 
             1860                1865                1870
Val Ser Tyr Glu Pro Ile Thr Thr Thr Leu Lys Arg Lys Gln Glu Glu 
         1875                1880                1885
Val Ser Ala Thr Ile Ile Gln Arg Ala Tyr Arg Arg Tyr Arg Leu Arg 
     1890                1895                1900
Gln His Val Lys Asn Ile Ser Ser Ile Tyr Ile Lys Asp Gly Asp Arg 
 1905                1910                1915                1920
Asp Asp Asp Leu Pro Asn Lys Glu Asp Thr Val Phe Asp Asn Val Asn 
                 1925                1930                1935
Glu Asn Ser Ser Pro Glu Lys Thr Asp Val Thr Ala Ser Thr Ile Ser 
             1940                1945                1950
Pro Pro Ser Tyr Asp Ser Val Thr Lys Pro Asp Gln Glu Lys Tyr Glu 
         1955                1960                1965
Thr Asp Lys Thr Glu Lys Glu Asp Lys Glu Lys Asp Glu Ser Arg Lys 
     1970                1975                1980



<210> 355
<211> 6371
<212> DNA
<213> Homo sapiens
<308> X82835
<400> 355

ctcttatgt  aggagctga  gaggaatta  aatatacag  atgaaaaga  ggcaatgtt  60
cctccccca  gacctcaga  ctttgtcca  ttcacaaaa  agtctcttg  cctcattga  120
caacgcatt  ctgaaagaa  atcaaagga  cccaaagaa  aaaagaaag  tgatgatga  180
gaagcccca  agccaagca  tgacttgga  gctggcaaa  aactgccct  catctatgg  240
gacattcct  ccggcatgg  gtcagagcc  ctggaggac  tggacccct  ctatgcaga  300
aaaaagact  tcatagtat  gaacaaagg  aaaacaatc  tccgtttca  tgccacacc  360
gctttatat  tgctttctc  tttcagtcc  ctaagaaga  tatctatta  gattttagt  420
cactcctta  tcagcatgc  catcatgtg  actattctg  caaactgca  atttatgac  480
atgaataac  cgccggact  gaccaaaaa  gtcgagtac  cttttactg  aatatatac  540
tttgaatca  ttgtaaaaa  ccttgcaag  ggcttctgt  taggagaat  cacttttct  600
cgtgacccg  ggaactggc  ggattttgt  gtcattgtt  ttgcgtatt  aacagaatt  660
gtaaaccta  gcaatgttt  agctcttcg  actttcaga  tattgagag  tttgaaaac  720
atttctgta  tcccaggcc  gaagacaat  gtaggggct  tgatccagt  agtgaagaa  780
ctttctgat  tcatgatcc  gactgtgtt  tgtctgagt  tgtttgcac  aattggact  840
cagctgttc  tgggaaacc  gaagcataa  tgttttcga  attcacttg  aaataatga  900
acattagaa  gcataatga  taccctaga  agtgaagaa  actttagaa  atattttta  960
tacttggaa  gatccaaag  tgctctcct  tgtggtttc  gcacagatt  aggtcagtg  1020
ccagagggg  acacctgtg  gaaaattgg  agaaaccct  attatggct  cacgagctt  1080
gacactttc  gctgggcct  cttagcctt  tttaggcta  tgacccaag  ttactggga  1140
aacctttac  aacagacgc  gcgtgctgc  ggcaaaacc  acatgatct  ctttgtcgt  1200
gtgattttc  tgggctcct  ttatctaat  aacttgatc  tggctgtgg  tgccatggc  1260
tatgaagaa  agaaccagg  aaacattga  gaagctaaa  agaaagaat  agaatttca  1320
cagatgtta  accgtctta  aaaagagca  gaagaagct  aggcaattg  agcggcagc  1380
gctgaatat  caagtatta  gagaagcag  attatgggc  tctcagaga  ttcttctga  1440
acatccaaa  tgagctcta  aagtgctaa  gaaagaaga  acagaagaa  gaaaaagaa  1500
caaaagaag  tctccagtg  agaggaaaa  ggagatgct  agaaattgt  gaaatcaga  1560
tcagaggac  gcatcagaa  aaaaagttt  caccttggt  tcgaagggc  taggcgagc  1620
catgaaaag  ggttgtcta  ccccaatca  tcaccactc  gcattcgtg  ctccttgtt  1680
tctgcaagg  gaagcagca  aacaagtct  tttagtttc  aaggcagag  aagagatat  1740
ggatctgag  ctgaatttg  cgatgatga  cacagcatt  ttggagaca  tgagagcag  1800
aggggctca  tgtttgtgc  ccacagacc  caggagcga  gcagcagta  catcagcca  1860
gccagtagg  ccccaccaa  gctgccggt  aacgggaaa  tgcacagtg  tgtggactg  1920
aacggtgtg  tctccctgg  tgatggacg  tcagccctc  tgctcccca  tggacagct  1980
ctgccagag  gcacgacca  tcaaataca  aagaaaagg  gttgtagtt  ctatctcct  2040
tcagaggat  tgctgaatg  tcccaacct  agacagaga  caatgagta  agcaagcat  2100
ttaacaaac  ctgtggaag  acttgaaga  tccagacaa  aatgtccac  ttggtggta  2160
agatttgca  acaaattct  gatctggaa  tgctctcca  attggataa  attcaaaaa  2220
tgtatctat  ttattgtaa  ggatccttt  gtagatctt  caattacca  ttgcatagt  2280
ttaaacaca  tatttatgg  tatggaaca  cacccaatg  ctgaggaat  caaaaatgt  2340
cttgctata  gaaatttgg  ctttactgg  atctttgca  ctgaaatgg  attaaaact  2400
attgccatg  atccatatg  gtatttcca  gtaggctgg  atatttttg  cagccttat  2460
gtgacttta  gtttagtgg  gctctttct  gcagatgtg  aaggattgt  agttctgcg  2520
tcattcaga  tgctccgag  cttcaagtt  gcaaaatcc  ggccaacat  gaacatgct  2580
attaagatc  ttggtaact  agtaggggc  ctaggtaac  tcaccttag  gttggccat  2640
atcgtcttc  tttttgctg  ggtcggcat  cagctcttt  gtaagagct  caaagaatg  2700
gtctgcaag  tcaatgatg  ctgtacgct  ccacggtgg  acatgaacg  cttcttcca  2760
tccttcctg  ttgtgttcc  cgtgctgtg  ggagagtgg  tagagacca  gtgggactg  2820
atggaggtc  ctggtcaag  tatgtgcct  attgtttac  tgatggtca  ggtcattgg  2880
aacctggtg  tcctaaacc  atttctggc  ttattattg  gctcattta  ttcagacaa  2940
cttacagca  ttgaagaag  ccctgatgc  aacaacctc  agattgcag  gactagaat  3000
aaaaaggga  taaattatg  gaaacaaac  ttacgtgaa  ttattctaa  agcattttc  3060
aaaaagcca  agatttcca  ggagataag  caagcagaa  atctgaata  taagaagga  3120
aactatatt  ctaaccata  acttgctga  atgagcaaa  gtcacaatt  cctcaagga  3180
aaagataaa  tcagtggtt  tggaagcag  gtggacaaa  acttgatgg  agacagtga  3240
ggtcaatca  ttattcaca  tcccagcct  acagtgaca  tgccaattg  acctgggga  3300
tccgatttg  aaaatatga  tgctgagga  cttagcagt  attcggata  tgaatacag  3360
aaagtgaga  taaaccggt  aagctcctc  gagtgcagc  cagttgata  ccctttgcc  3420
ggagaagga  aagaagcag  ggctgaacc  atgaattcc  atgagccag  ggcctgttt  3480
acagatggt  gtgtacgga  gttctcatg  tgccaagtt  acatagagt  agggaaagg  3540
aaaatctgg  ggaacatca  gaaaacctg  tacaagatt  ttgaacaca  ttggtttga  3600
agcttcatt  tcctcatga  cctgctcag  agtggtgcc  tggcttttg  agatattta  3660
attgaaagg  aaaagacca  taagattat  ctggagtat  cagacaaga  cttcactta  3720
atcttcatt  tggaaatgc  tctaaaatg  atagcatat  gttataaaa  atatttcac  3780
aatgcctgg  gttggctgg  tttcctaat  gttgatgtt  ctttggtta  tttagtggc  3840
aacactctt  gctactcag  tcttggccc  attaaatcc  ttcggacac  gagagcttt  3900
agacctcta  gagccttat  tagatttga  ggaatgagg  tcgttgtga  tgcactcat  3960
ggagcaatt  cttccatca  gaatgtgct  cttgtgtgt  ttatattct  gctgatatt  4020
agcatcatg  gagtaaatt  gtttgctgg  aagttctat  agtgtatta  caccacaga  4080
gggtcacgg  ttcctgcaa  tcaagttcc  aatcgttcc  aatgttttg  ccttatgaa  4140
gttagtcaa  atgtgcgat  gaaaaacct  aaagtgaac  ttgataatg  cggacttgg  4200
tacctatct  tgcttcaag  tgcaacttt  aagggatgg  cgattatta  gtatgcagc  4260
gtggattct  ttaatgtag  caagcagcc  aaatatgaa  atagcctct  catgtatat  4320
tattttgtc  tctttatca  ctttgggtc  ttcttcact  tgaacttgt  cattggtgt  4380
atcatagat  atttcaacc  acagaaaaa  aagcttgga  gtcaagaca  ctttatgac  4440
gaagaacag  agaaatact  taatgcaat  aaaaagctg  ggtccaaga  gccacaaaa  4500
ccaattcct  gaccaggga  caaaatcca  ggatgtata  ttgacctag  gacaaatca  4560
gcctttgat  ttagtatca  ggttcttat  tgtctcaac  tggtaacca  gatggtaga  4620
aaggagggt  aaagtcaac  tatgactga  gttttatat  ggataaatg  ggtttttat  4680
atccttttc  ctggagaat  tgtgctaaa  ctgatctcc  tcagacact  ctacttcac  4740
gtaggatgg  atatttttg  ttttgtggt  gtgattatc  ccattgtag  tatgtttct  4800
gctgatttg  ttgaaacgt  ttttgtgtc  cctaccctg  tccgagtga  ccgtcttgc  4860
aggattggc  gaatcctac  tctagtcaa  ggagcaaag  ggatccgca  gctgctctt  4920
gctttgatg  tgtcccttc  tgcgttgtt  aacatcggc  tcctgctct  cctggtcat  4980
ttcatctac  ccatctttg  aatgtccaa  tttgcctat  ttaaaaagg  agatggaat  5040
aatgacatg  tcaattttg  gacctttgg  aacagtatg  tttgcctgt  ccaaattac  5100
acctctgct  gctgggatg  attgctagc  cctattctt  acagtaagc  acccgactg  5160
gacccaaaa  aagttcatc  tggaagttc  gttgaagga  actgtggta  cccatctgt  5220
ggaatattc  actttgtta  ttatatcat  atatccttc  tggttgtgg  gaacatgta  5280
attgcagtc  tactggaga  ttttagtgt  gccactgaa  aaagtactg  acctctgag  5340
gaggatgac  ttgagatgt  ctatgaggt  tgggagaag  ttgatcccg  tgcgaccca  5400
tttatagag  tctctaaac  ctctgattt  gcagctgcc  tggatcctc  tcttctcat  5460
gcaaaaccc  acaaagtcc  gctcattgc  atggatctg  ccatggtta  tggtgaccg  5520
atccattgt  ttgacatct  atttgcttt  acaaagcgt  ttttgggtg  gagtgggga  5580
atggattct  ttcgttcac  gatggaaga  aggttcatg  ctgcaaatc  ttccaaagt  5640
tcctatgaa  ccatcacaa  cacactaaa  cggaaacaa  aggatgtgt  tgctactgt  5700
attcagcgt  cttatagac  ttaccgctt  aggcaaaat  tcaaaaata  atcaagtat  5760
tacataaaa  atggagaca  agatgatga  ttactcaat  aaaaagata  ggcttttga  5820
aatgttaat  agaactcaa  tccagaaaa  acagatgcc  cttcatcca  cacctctcc  5880
ccttcatat  atagtgtaa  aaagccaga  aaagagaaa  atgaacaag  cagaacaga  5940
aaggaagac  aagggaaag  cagcaagga  agcaaaaaa  agagcttca  ttttgatat  6000
ttgtttaca  cctgtgaaa  tgatttatt  gtgttaata  aactctttt  aggaagtct  6060
tgccaaaat  ctttttatc  aaatattct  gaaggcagt  cagtcacta  ctctgattt  6120
ctaagaaag  tgggcagca  tagcagatg  ttatttttg  actgatgat  ctttaagaa  6180
cgtaagaga  ctctgtagg  attattgat  atagcatac  aaagtgatt  attcagttt  6240
ttggttttt  ataaatcag  agaccatgt  gaaaacttt  acatctgcc  tgtcatctt  6300
tcacaggat  gtaattagt  ttgtttccc  tgtaaataa  caacacacg  atacagaaa  6360
aaaaaaaaa  a  6371



<210> 356
<211> 1978
<212> PRT
<213> Homo sapiens
<308> X82835
<400> 356

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
  1               5                  10                  15
Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
             20                  25                  30
Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
         35                  40                  45
Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
     50                  55                  60
Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
 65                  70                  75                  80
Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                 85                  90                  95
Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
             100                105                110
Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
         115                120                125
Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
     130                135                140
Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
 145                150                155                160
Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                 165                170                175
Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
             180                185                190
Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
         195                200                205
Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
     210                215                220
Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
 225                230                235                240
Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                 245                250                255
Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
             260                265                270
His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
         275                280                285
Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
     290                295                300
Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
 305                310                315                320
Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                 325                330                335
Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
             340                345                350
Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
         355                360                365
Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
     370                375                380
Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
 385                390                395                400
Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                 405                410                415
Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
             420                425                430
Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
         435                440                445
Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
     450                455                460
Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
 465                470                475                480
Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                 485                490                495
Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
             500                505                510
Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
         515                520                525
Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
     530                535                540
Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
 545                550                555                560
Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                 565                570                575
Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
             580                585                590
Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
         595                600                605
Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
     610                615                620
Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
 625                630                635                640
Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                 645                650                655
Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
             660                665                670
Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
         675                680                685
Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
     690                695                700
Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
 705                710                715                720
Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                 725                730                735
Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
             740                745                750
Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
         755                760                765
Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
     770                775                780
Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
 785                790                795                800
Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                 805                810                815
Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
             820                825                830
Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
         835                840                845
Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
     850                855                860
Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
 865                870                875                880
Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                 885                890                895
Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
             900                905                910
Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
         915                920                925
Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
     930                935                940
Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
 945                950                955                960
Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                 965                970                975
Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
             980                985                990
Gln Thr Leu Arg Glu Phe Ile Leu Lys Ala Phe Ser Lys Lys Pro Lys 
         995                1000                1005
Ile Ser Arg Glu Ile Arg Gln Ala Glu Asp Leu Asn Thr Lys Lys Glu 
     1010                1015                1020
Asn Tyr Ile Ser Asn His Thr Leu Ala Glu Met Ser Lys Gly His Asn 
 1025                1030                1035                1040
Phe Leu Lys Glu Lys Asp Lys Ile Ser Gly Phe Gly Ser Ser Val Asp 
                 1045                1050                1055
Lys His Leu Met Glu Asp Ser Asp Gly Gln Ser Phe Ile His Asn Pro 
             1060                1065                1070
Ser Leu Thr Val Thr Val Pro Ile Ala Pro Gly Glu Ser Asp Leu Glu 
         1075                1080                1085
Asn Met Asn Ala Glu Glu Leu Ser Ser Asp Ser Asp Ser Glu Tyr Ser 
     1090                1095                1100
Lys Val Arg Leu Asn Arg Ser Ser Ser Ser Glu Cys Ser Thr Val Asp 
 1105                1110                1115                1120
Asn Pro Leu Pro Gly Glu Gly Glu Glu Ala Glu Ala Glu Pro Met Asn 
                 1125                1130                1135
Ser Asp Glu Pro Glu Ala Cys Phe Thr Asp Gly Cys Val Arg Arg Phe 
             1140                1145                1150
Ser Cys Cys Gln Val Asn Ile Glu Ser Gly Lys Gly Lys Ile Trp Trp 
         1155                1160                1165
Asn Ile Arg Lys Thr Cys Tyr Lys Ile Val Glu His Ser Trp Phe Glu 
     1170                1175                1180
Ser Phe Ile Val Leu Met Ile Leu Leu Ser Ser Gly Ala Leu Ala Phe 
 1185                1190                1195                1200
Glu Asp Ile Tyr Ile Glu Arg Lys Lys Thr Ile Lys Ile Ile Leu Glu 
                 1205                1210                1215
Tyr Ala Asp Lys Ile Phe Thr Tyr Ile Phe Ile Leu Glu Met Leu Leu 
             1220                1225                1230
Lys Trp Ile Ala Tyr Gly Tyr Lys Thr Tyr Phe Thr Asn Ala Trp Cys 
         1235                1240                1245
Trp Leu Asp Phe Leu Ile Val Asp Val Ser Leu Val Thr Leu Val Ala 
     1250                1255                1260
Asn Thr Leu Gly Tyr Ser Asp Leu Gly Pro Ile Lys Ser Leu Arg Thr 
 1265                1270                1275                1280
Leu Arg Ala Leu Arg Pro Leu Arg Ala Leu Ser Arg Phe Glu Gly Met 
                 1285                1290                1295
Arg Val Val Val Asn Ala Leu Ile Gly Ala Ile Pro Ser Ile Met Asn 
             1300                1305                1310
Val Leu Leu Val Cys Leu Ile Phe Trp Leu Ile Phe Ser Ile Met Gly 
         1315                1320                1325
Val Asn Leu Phe Ala Gly Lys Phe Tyr Glu Cys Ile Asn Thr Thr Asp 
     1330                1335                1340
Gly Ser Arg Phe Pro Ala Ser Gln Val Pro Asn Arg Ser Glu Cys Phe 
 1345                1350                1355                1360
Ala Leu Met Asn Val Ser Gln Asn Val Arg Trp Lys Asn Leu Lys Val 
                 1365                1370                1375
Asn Phe Asp Asn Val Gly Leu Gly Tyr Leu Ser Leu Leu Gln Val Ala 
             1380                1385                1390
Thr Phe Lys Gly Trp Thr Ile Ile Met Tyr Ala Ala Val Asp Ser Val 
         1395                1400                1405
Asn Val Asp Lys Gln Pro Lys Tyr Glu Tyr Ser Leu Tyr Met Tyr Ile 
     1410                1415                1420
Tyr Phe Val Val Phe Ile Ile Phe Gly Ser Phe Phe Thr Leu Asn Leu 
 1425                1430                1435                1440
Phe Ile Gly Val Ile Ile Asp Asn Phe Asn Gln Gln Lys Lys Lys Leu 
                 1445                1450                1455
Gly Gly Gln Asp Ile Phe Met Thr Glu Glu Gln Lys Lys Tyr Tyr Asn 
             1460                1465                1470
Ala Met Lys Lys Leu Gly Ser Lys Lys Pro Gln Lys Pro Ile Pro Arg 
         1475                1480                1485
Pro Gly Asn Lys Ile Gln Gly Cys Ile Phe Asp Leu Val Thr Asn Gln 
     1490                1495                1500
Ala Phe Asp Ile Ser Ile Met Val Leu Ile Cys Leu Asn Met Val Thr 
 1505                1510                1515                1520
Met Met Val Glu Lys Glu Gly Gln Ser Gln His Met Thr Glu Val Leu 
                 1525                1530                1535
Tyr Trp Ile Asn Val Val Phe Ile Ile Leu Phe Thr Gly Glu Cys Val 
             1540                1545                1550
Leu Lys Leu Ile Ser Leu Arg His Tyr Tyr Phe Thr Val Gly Trp Asn 
         1555                1560                1565
Ile Phe Asp Phe Val Val Val Ile Ile Ser Ile Val Gly Met Phe Leu 
     1570                1575                1580
Ala Asp Leu Ile Glu Thr Tyr Phe Val Ser Pro Thr Leu Phe Arg Val 
 1585                1590                1595                1600
Ile Arg Leu Ala Arg Ile Gly Arg Ile Leu Arg Leu Val Lys Gly Ala 
                 1605                1610                1615
Lys Gly Ile Arg Thr Leu Leu Phe Ala Leu Met Met Ser Leu Pro Ala 
             1620                1625                1630
Leu Phe Asn Ile Gly Leu Leu Leu Phe Leu Val Met Phe Ile Tyr Ala 
         1635                1640                1645
Ile Phe Gly Met Ser Asn Phe Ala Tyr Val Lys Lys Glu Asp Gly Ile 
     1650                1655                1660
Asn Asp Met Phe Asn Phe Glu Thr Phe Gly Asn Ser Met Ile Cys Leu 
 1665                1670                1675                1680
Phe Gln Ile Thr Thr Ser Ala Gly Trp Asp Gly Leu Leu Ala Pro Ile 
                 1685                1690                1695
Leu Asn Ser Lys Pro Pro Asp Cys Asp Pro Lys Lys Val His Pro Gly 
             1700                1705                1710
Ser Ser Val Glu Gly Asp Cys Gly Asn Pro Ser Val Gly Ile Phe Tyr 
         1715                1720                1725
Phe Val Ser Tyr Ile Ile Ile Ser Phe Leu Val Val Val Asn Met Tyr 
     1730                1735                1740
Ile Ala Val Ile Leu Glu Asn Phe Ser Val Ala Thr Glu Glu Ser Thr 
 1745                1750                1755                1760
Glu Pro Leu Ser Glu Asp Asp Phe Glu Met Phe Tyr Glu Val Trp Glu 
                 1765                1770                1775
Lys Phe Asp Pro Asp Ala Thr Gln Phe Ile Glu Phe Ser Lys Leu Ser 
             1780                1785                1790
Asp Phe Ala Ala Ala Leu Asp Pro Pro Leu Leu Ile Ala Lys Pro Asn 
         1795                1800                1805
Lys Val Gln Leu Ile Ala Met Asp Leu Pro Met Val Ser Gly Asp Arg 
     1810                1815                1820
Ile His Cys Leu Asp Ile Leu Phe Ala Phe Thr Lys Arg Val Leu Gly 
 1825                1830                1835                1840
Glu Ser Gly Glu Met Asp Ser Leu Arg Ser Gln Met Glu Glu Arg Phe 
                 1845                1850                1855
Met Ser Ala Asn Pro Ser Lys Val Ser Tyr Glu Pro Ile Thr Thr Thr 
             1860                1865                1870
Leu Lys Arg Lys Gln Glu Asp Val Ser Ala Thr Val Ile Gln Arg Ala 
         1875                1880                1885
Tyr Arg Arg Tyr Arg Leu Arg Gln Asn Val Lys Asn Ile Ser Ser Ile 
     1890                1895                1900
Tyr Ile Lys Asp Gly Asp Arg Asp Asp Asp Leu Leu Asn Lys Lys Asp 
 1905                1910                1915                1920
Met Ala Phe Asp Asn Val Asn Glu Asn Ser Ser Pro Glu Lys Thr Asp 
                 1925                1930                1935
Ala Thr Ser Ser Thr Thr Ser Pro Pro Ser Tyr Asp Ser Val Thr Lys 
             1940                1945                1950
Pro Asp Lys Glu Lys Tyr Glu Gln Asp Arg Thr Glu Lys Glu Asp Lys 
         1955                1960                1965
Gly Lys Asp Ser Lys Glu Ser Lys Lys Ter 
     1970                1975



<210> 357
<211> 2426
<212> DNA
<213> Rattus norvegicus
<308> AF000423
<400> 357

ggcattctc  cccccaagc  gcaggcctt  ctctgttcg  ttttaagta  agacgtccc  60
ggagcatct  agagaaaaa  gcagctagc  accaaggat  gtactgtcg  aggagcagt  120
ggccatgca  cttcccctc  cttgatctg  aggtctaca  ccggggcct  ggtactgat  180
gagatttcc  aagttgtct  acctctgca  aagtgtttc  atcaacagc  tctgattac  240
acatggctg  gatcacaaa  atacgcccc  gctttgatg  gtcaccagt  gcggctggc  300
tcatcggcg  ctctgtgct  gtggtgtgt  tctctgtga  tgtctttgt  tggacatgc  360
gccaccagc  ggcggagaa  aagcacaag  ccccaccgt  caagtttat  catatgctg  420
aaggcatta  catctaccc  gagaccctc  gcaacaaga  ggaaatcat  aaagttcgg  480
gggacaaag  tggttctca  agggaaagt  gacgaggga  cctgttagt  aatgcggag  540
ctggcctcc  gagccatga  agggatccc  gagggccta  ccctgcatc  tgtatagac  600
agttaccca  caaaagaga  tatggggaa  aactgagga  ccccatgac  agcctgacc  660
ccggtgaaa  caagcccac  tccccatca  cgccagagg  agatgtgat  ctagggtcc  720
ttaccttct  ggtggacta  aactttccc  agaaagctc  ggtggtgac  atccaagag  780
cgcatgggc  gccagtgat  gatggccag  cccagggct  cgatcccta  atcaaaatg  840
ccattcttc  tgacaagcg  catcgagtg  agacccggg  gcttcgcaa  accctggac  900
ccgtgtttg  tgagacctt  accttctac  gcattccct  cagccagct  caggacctg  960
tgctgcact  ccttgtgct  agctttgat  gcttctctc  ggatgacgt  atcggggag  1020
tcatggtgc  cttggctgg  gtggacccc  gcacaggca  ggttcagct  accagggac  1080
tcatcaaga  gaacattca  aagtgcatt  gcagagggg  actccaggt  tctctgtca  1140
accagcccg  cgcacagag  atgacagtc  tggtcctca  agccagaca  ttgccgaag  1200
tggatatca  cggtctctc  ggtaatcct  atgtcaagg  gaacgtcta  tacggcaga  1260
aacgcattg  caagaagaa  actcatgta  agaagtgca  tttgaaccc  atcttcaat  1320
agtccttca  ctatgacat  cccaccgat  tcctgcctg  tatcagcat  gagttcctt  1380
tcattgact  cgatcgtac  actaagaat  aggtggtag  gaggctgat  ttgggggca  1440
acagtgtca  aaccagtgg  gcagaacac  ggagagagg  gtgcgagag  ccccgcaag  1500
ctgtagcca  gtggcacag  ctgagcgag  actaaccct  gggccaggc  gggaggcac  1560
cacggggag  ggtgacaga  aagctgact  aaaacctca  tttagtcgt  gaagatttc  1620
tacagaaca  accacacga  gaacctcac  ctccacacg  ctgcagatt  gttcttagc  1680
tgaggattg  tttcttctc  gcaaggcac  agacgatct  ttgtttttt  aaatgaggg  1740
ggaagagaa  ggaagaccc  aagtctata  ataacaatg  aaccttata  ttgcatgtc  1800
aatacaaac  agaaattag  ctaacaata  caagttgca  attttaatc  atgaaaatt  1860
tgttttgtg  cgaactgta  ttgctgatc  cctgaaatt  gcctctctt  atcaggctt  1920
tctgggtta  tccagtttt  catcaccgc  ggagaaaag  ctgctcttg  aaagcccca  1980
gtccccatc  tccagtccc  tttgctgtc  cctctcaca  ctctgctct  tggctgagt  2040
acaaatcct  aggtctgta  taagtgagg  aatgagtgg  gtttccagg  gaaagagtg  2100
ttgagaatg  gatgtgtgg  tagtaggca  ccagtgact  gagattccc  tgatgagct  2160
aggaggagt  gggctggac  taggactct  atttctcca  aaggagcaa  ggagggttc  2220
cctagagcg  ggtacctgt  aacagtacc  gcgcgtcct  aaagctgct  gcaggtcag  2280
ggaccaggg  atgaaataa  atgtccatg  ggccctctg  ggtgggctc  tcatcagtg  2340
tcagcagtc  caggtttgt  aggttacac  ggcttttac  tttccagaa  tgtgccggg  2400
gctcaggca  ctcttcatt  tgtagc  2426



<210> 358
<211> 430
<212> PRT
<213> Rattus norvegicus
<308> O08835
<400> 358

Met Ala Glu Ile Thr Asn Ile Arg Pro Ser Phe Asp Val Ser Pro Val 
  1               5                  10                  15
Ala Ala Gly Leu Ile Gly Ala Ser Val Leu Val Val Cys Val Ser Val 
             20                  25                  30
Thr Val Phe Val Trp Thr Cys Cys His Gln Gln Ala Glu Lys Lys His 
         35                  40                  45
Lys Thr Pro Pro Tyr Lys Phe Ile His Met Leu Lys Gly Ile Ser Ile 
     50                  55                  60
Tyr Pro Glu Thr Leu Ser Asn Lys Lys Glu Ile Ile Lys Val Arg Arg 
 65                  70                  75                  80
Asp Lys Asp Gly Ser His Arg Glu Ser Gly Arg Gly Asn Leu Leu Val 
                 85                  90                  95
Asn Ala Glu Ser Gly Leu Leu Ser His Asp Arg Asp Pro Arg Gly Pro 
             100                105                110
Ser Pro Ala Ser Cys Ile Asp Gln Leu Pro Ile Lys Arg Asp Tyr Gly 
         115                120                125
Glu Glu Leu Arg Ser Pro Met Thr Ser Leu Thr Pro Gly Glu Ser Lys 
     130                135                140
Pro Thr Ser Pro Ser Ser Pro Glu Glu Asp Val Met Leu Gly Ser Leu 
 145                150                155                160
Thr Phe Ser Val Asp Tyr Asn Phe Pro Lys Lys Ala Leu Val Val Thr 
                 165                170                175
Ile Gln Glu Ala His Gly Leu Pro Val Met Asp Gly Gln Thr Gln Gly 
             180                185                190
Ser Asp Pro Tyr Ile Lys Met Thr Ile Leu Pro Asp Lys Arg His Arg 
         195                200                205
Val Lys Thr Arg Val Leu Arg Lys Thr Leu Asp Pro Val Phe Asp Glu 
     210                215                220
Thr Phe Thr Phe Tyr Gly Ile Pro Tyr Ser Gln Leu Gln Asp Leu Val 
 225                230                235                240
Leu His Phe Leu Val Leu Ser Phe Asp Arg Phe Ser Arg Asp Asp Val 
                 245                250                255
Ile Gly Glu Val Met Val Pro Leu Ala Gly Val Asp Pro Ser Thr Gly 
             260                265                270
Lys Val Gln Leu Thr Arg Asp Ile Ile Lys Arg Asn Ile Gln Lys Cys 
         275                280                285
Ile Ser Arg Gly Glu Leu Gln Val Ser Leu Ser Tyr Gln Pro Val Ala 
     290                295                300
Gln Arg Met Thr Val Val Val Leu Lys Ala Arg His Leu Pro Lys Met 
 305                310                315                320
Asp Ile Thr Gly Leu Ser Gly Asn Pro Tyr Val Lys Val Asn Val Tyr 
                 325                330                335
Tyr Gly Arg Lys Arg Ile Ala Lys Lys Lys Thr His Val Lys Lys Cys 
             340                345                350
Thr Leu Asn Pro Ile Phe Asn Glu Ser Phe Ile Tyr Asp Ile Pro Thr 
         355                360                365
Asp Leu Leu Pro Asp Ile Ser Ile Glu Phe Leu Val Ile Asp Phe Asp 
     370                375                380
Arg Thr Thr Lys Asn Glu Val Val Gly Arg Leu Ile Leu Gly Ala His 
 385                390                395                400
Ser Val Thr Thr Ser Gly Ala Glu His Trp Arg Glu Val Cys Glu Ser 
                 405                410                415
Pro Arg Lys Pro Val Ala Lys Trp His Ser Leu Ser Glu Tyr 
             420                425                430



<210> 359
<211> 4001
<212> DNA
<213> Homo sapiens
<308> D38522
<400> 359

cccaggtaa  ccttatgtc  aggtgaacg  ctactacgg  agaaagcgc  ttgccaaga  60
gaaaaccca  gtgaagaag  gcactttga  ccccatctt  aatgaatct  tcatctacg  120
catccccac  gacctcctg  ctgatatca  catcgagtt  ctcgttatc  acttcgatc  180
caccaccaa  aatgaggtg  tggggaggc  gatcctggg  gcacacagt  tcacagcca  240
tggtgctga  cactggaga  aggtctgcg  gagcccccg  aagcctgtg  ccaagtggc  300
cagtctgag  gagtactaa  cctgttctt  tctcctcta  tccccgggg  ccaagctgg  360
gagggatgt  gaggggaaa  agatgacag  gaagtggac  ccaaacctc  ttttagttg  420
agaagaaaa  ttcttacaa  acaaattcc  caaagaaca  cctatatga  cacagctgc  480
gatcagttc  tagcaatga  gtttttttt  ctgctttgc  aggcgctag  atcttttat  540
ttactttat  ttttttgag  tggagtttc  ctcttgttg  ccgggctgg  gtgcaatgg  600
gagatctca  ctcactgca  cctctgccc  ccaggttca  gtgattctc  tccctcagc  660
tcccaagta  ctgggatta  aggcaccca  gagcatgcc  ggctaattt  ttgtatttt  720
agtagagat  ggtttcacc  tgttggcca  gctggtctc  aattccaga  ctcaggtga  780
ccacccgcc  cggcctccc  aagtgctgg  attacaggt  cgagccacc  tgcccggcc  840
ctggttttg  tttgttttt  ttttttaat  ggggacaaa  gagagggaa  gacccctat  900
aatctatat  taacaatgt  accatatac  tgcatgtct  atacaaact  aagaaatta  960
cctaactgc  aatatcaag  tgcagattt  aatccatgg  aattgtgtt  tgtgctgaa  1020
tgtatttgc  gattacctg  aattggctt  tttttattg  gcttctctg  agaatttct  1080
ccactcccc  cctctgcag  agaaaattt  gctcttata  aacctcatg  tttcatcat  1140
cccatcttt  ctttttatt  cctcttata  ctctgctct  tgacctcaa  gtctagagg  1200
ctgcagtaa  ccaagaaac  aaggtgggg  ggatgaggc  aggtttgca  gagaaagag  1260
aattgagaa  tggggtatt  ttgctatca  ctcttctgc  atgaagtag  aaaaggcag  1320
ctataatta  ctgacagac  taactgaag  acagagaat  catcagact  atgcatcca  1380
gacatcaga  cttggattt  atcaaactt  atgacttct  taaaaggag  tttggaaac  1440
tcaaattca  ctataggat  gtaccaatg  acacatcca  ctgatccca  aagctgttt  1500
caggtataa  gacaaggag  ggagacaag  gacgacagc  attcccctt  gcagctatc  1560
actgtagtg  cagccattt  ttggttgat  ggttggaag  catcagagg  ttgaagaat  1620
acactggcc  ttgtttttc  ggaaatgcc  accatggag  tgctttaga  tcttctcaa  1680
tagcttaga  gttgtaatg  ggttagctt  gcttcataa  acaggggcc  tcagaagtt  1740
tccttaaat  tttcaataa  aatttagct  ttaaaaaaa  aacagtgtg  ctgagtgaa  1800
gaagataag  tggattctt  cagagcatt  ttttcctca  aacgagctg  ataattctt  1860
gaatttatg  cttaccaca  ggtggaggg  tggaggaac  acaggatgc  attcttctt  1920
taccaatgg  caatagagg  tgagagaga  tcagcatct  tctgggatt  gaattcaag  1980
ctctttact  ctacagcag  tgtgtctcc  acgttgaga  tttgcagat  gcacagact  2040
catggataa  aggtaaact  ggggccggg  gcagtggct  acgcctgta  tcccagtat  2100
ttgggaggc  gaggtggaa  gatcgcttg  gcccaggag  tcaagacca  cctgggcta  2160
atgacgaaa  tccatctct  tcaaaaata  aaaaaatta  ctaggtgtg  tgctgcacg  2220
ctgtggtcc  agctattca  gaggctgag  tgggaggat  atttgagcc  agaggtaga  2280
gctgcagtg  gccatgatc  tgccactgc  ctctgggct  ggtaacaga  tgagatcct  2340
tctcaaaaa  taattaatt  attaattaa  ataaactag  taaacttgg  taggcagta  2400
atatttttg  ccacctgag  aggaactca  tcaagctgt  gcttaacag  ttgatccag  2460
gcgtgaaag  ttagttgag  ctgaagtgt  cacttccat  gaagaacat  acttttaac  2520
ttgctttgg  gaagggagt  ggaaagctg  gtctctatg  acggggggg  gatcttgct  2580
tcagtgttc  ctcagcttt  gtggattta  aaccattct  ctcccccta  accttttgt  2640
tgatttcag  ccatgttct  gacaatgca  agcaattct  agcagtcac  aagcctact  2700
tctgttctt  tccctgcca  cccccaccc  ccataatct  actcacaac  tcaccatca  2760
ttggggtca  accactagt  tctgtccta  accccatga  atgtaaata  tgtatcata  2820
gtagaagaa  ataattttt  ttttctaaa  atgcatttt  agatagttt  atgtaaatc  2880
gacaggagc  ttctgaagc  ccattagga  aaaatttaa  tggttcctc  tcatcgcct  2940
aatgtctaa  gatcagaaa  cgctgagca  acccgcttt  gtttccttc  cagaaacaa  3000
gcaaaacaa  aggtggaga  agtctggtc  ttgccctgc  gtgtgtgcc  ctgtagctc  3060
tcctgacaa  cgtctggga  aacagcctc  ccccactct  ctctctctt  cccatttcc  3120
tgtagcttt  ttccttgca  ctttgggtc  actgagcag  gggtgctga  gtgacaggg  3180
aggaaccag  tgttctgta  cctaggaac  gcctcagtg  ctttgccag  aaaaggcaa  3240
gaggcggac  gtgcagggc  cctccctcc  acctcaggc  tgatccatc  tgcccttga  3300
tttgccgtc  caaagtttc  tagctgact  tggctttca  atttgttct  tccagagct  3360
actgataag  gtggaggag  aatgccttc  cctaagagt  agttgaaag  aagacaaga  3420
agtcacatc  tagcttttg  acaaggcat  cgtggtcag  aataggtta  ggaatggtc  3480
cttctgatt  tccaacagt  gctccttct  tgaagagat  ttgattcct  tgggaagac  3540
agaattttt  ttaataaca  aggtccctt  atgagttat  ccttctttc  gttcatctc  3600
ctggagcac  gccaagatg  acatgttta  ggacagtgc  ctagatgtg  aaacagata  3660
aactggttt  tgggacagg  gcagcttgc  caggagagg  aataacgca  gtccctttt  3720
ttggaaggc  tgtactatg  ccatgacag  gacattgcc  tcaccatga  ccctctcca  3780
agtggttgt  tttctttac  ttgtgtctt  tcttgtaaa  atgaaactc  aaaataaaa  3840
aaatgtgtc  aattttgaa  aaaaaagaa  actgaaaaa  ctaacatga  ttgtgtgaa  3900
ttgcataat  ctgtaatgc  aatctacaa  atgtaatgc  atcttgtat  ttgaatttg  3960
taatgcacc  cacaagtgc  aaataaaga  tgattcaca  t  4001



<210> 360
<211> 431
<212> PRT
<213> Homo sapiens
<308> Q9BT88
<400> 360

Met Ala Glu Ile Thr Asn Ile Arg Pro Ser Phe Asp Val Ser Pro Val 
  1               5                  10                  15
Val Ala Gly Leu Ile Gly Ala Ser Val Leu Val Val Cys Val Ser Val 
             20                  25                  30
Thr Val Phe Val Trp Ser Cys Cys His Gln Gln Ala Glu Lys Lys His 
         35                  40                  45
Lys Asn Pro Pro Tyr Lys Phe Ile His Met Leu Lys Gly Ile Ser Ile 
     50                  55                  60
Tyr Pro Glu Thr Leu Ser Asn Lys Lys Lys Ile Ile Lys Val Arg Arg 
 65                  70                  75                  80
Asp Lys Asp Gly Pro Gly Arg Glu Gly Gly Arg Arg Asn Leu Leu Val 
                 85                  90                  95
Asp Ala Ala Glu Ala Gly Leu Leu Ser Arg Asp Lys Asp Pro Arg Gly 
             100                105                110
Pro Ser Ser Gly Ser Cys Ile Asp Gln Leu Pro Ile Lys Met Asp Tyr 
         115                120                125
Gly Glu Glu Leu Arg Ser Pro Ile Thr Ser Leu Thr Pro Gly Glu Ser 
     130                135                140
Lys Thr Thr Ser Pro Ser Ser Pro Glu Glu Asp Val Met Leu Gly Ser 
 145                150                155                160
Leu Thr Phe Ser Val Asp Tyr Asn Phe Pro Lys Lys Ala Leu Val Val 
                 165                170                175
Thr Ile Gln Glu Ala His Gly Leu Pro Val Met Asp Asp Gln Thr Gln 
             180                185                190
Gly Ser Asp Pro Tyr Ile Lys Met Thr Ile Leu Pro Asp Lys Arg His 
         195                200                205
Arg Val Lys Thr Arg Val Leu Arg Lys Thr Leu Asp Pro Val Phe Asp 
     210                215                220
Glu Thr Phe Thr Phe Tyr Gly Ile Pro Tyr Ser Gln Leu Gln Asp Leu 
 225                230                235                240
Val Leu His Phe Leu Val Leu Ser Phe Asp Arg Phe Ser Arg Asp Asp 
                 245                250                255
Val Ile Gly Glu Val Met Val Pro Leu Ala Gly Val Asp Pro Ser Thr 
             260                265                270
Gly Lys Val Gln Leu Thr Arg Asp Ile Ile Lys Arg Asn Ile Gln Lys 
         275                280                285
Cys Ile Ser Arg Gly Glu Leu Gln Val Ser Leu Ser Tyr Gln Pro Val 
     290                295                300
Ala Gln Arg Met Thr Val Val Val Leu Lys Ala Arg His Leu Pro Lys 
 305                310                315                320
Met Asp Ile Thr Gly Leu Ser Gly Asn Pro Tyr Val Lys Val Asn Val 
                 325                330                335
Tyr Tyr Gly Arg Lys Arg Ile Ala Lys Lys Lys Thr His Val Lys Lys 
             340                345                350
Cys Thr Leu Asn Pro Ile Phe Asn Glu Ser Phe Ile Tyr Asp Ile Pro 
         355                360                365
Thr Asp Leu Leu Pro Asp Ile Ser Ile Glu Phe Leu Val Ile Asp Phe 
     370                375                380
Asp Arg Thr Thr Lys Asn Glu Val Val Gly Arg Leu Ile Leu Gly Ala 
 385                390                395                400
His Ser Val Thr Ala Ser Gly Ala Glu His Trp Arg Glu Val Cys Glu 
                 405                410                415
Ser Pro Arg Lys Pro Val Ala Lys Trp His Ser Leu Ser Glu Tyr 
             420                425                430



<210> 361
<211> 1493
<212> DNA
<213> Rattus norvegicus
<308> AF000899
<400> 361

ggaaacttt  gtaaaatgt  tctttacat  gaaatttca  tttaggcaa  cattggtct  60
tattattga  ttgatttta  ttgtagaac  aagagcccc  cattgagtg  ctattcaga  120
ttcaaagtg  ctcgaattg  ttacatagc  tctacctga  ggatttaga  tctgttttc  180
gatagcaaa  ctaatatat  tggtggcca  agtataact  tgttcatac  ttggcctgg  240
agataattt  tcatgagct  ttactattt  aaatgttac  catttgcct  ctattttat  300
aatgatgtt  ccttcagaa  ttgtgggaa  gtagaaaac  caaaatatc  cgcatcttt  360
gtgcaatgg  aagtcttga  ttttgatgt  ctaaatatg  ttgcagaaa  tgttctgtt  420
ctcttaaaa  atggaccta  atatgacaa  aatccatgc  atctgggta  ttctcccaa  480
ctgtaaggc  gaggactgt  gtgtgcgtt  ttctttagt  tcttccacc  gcagtgcct  540
ctgttaaaa  gtgacagtc  cccaatgtt  aagaaactg  acatatgct  tctctgtta  600
tcttgttag  cataagaaa  taatatgtt  cttttcctg  tgtaacatt  tacaaaaga  660
ctgctagtc  gatctttat  cttaaatta  tctcaaact  gatgtaaaa  tttaaaaat  720
ttttttaat  tattttttt  atagtagta  aagaactct  gctgctact  agttgttat  780
ctgttttcc  gatagaagc  atttaaaaa  gtccagttt  tgtcccagg  tagcaaaat  840
tacttcctc  ttttgttgt  ttgtgattt  taaattaca  taccttttg  atatacaaa  900
ctcattctt  attggacaa  gtgaaggct  tgggttttt  gaagttaaa  ttgaaggtg  960
agtttgctt  ggcattccc  cagctctaa  atgtattaa  cactgtgct  gcagaggcc  1020
ggactaaga  tgtactatg  aacttactg  gtacttttc  caaattatt  tcaaaggag  1080
gatttttag  tttttgtat  ctgcttagt  taaaaaaaa  aaaagagta  tttccacga  1140
gggttagtg  atttgatgc  gttgctgcc  aacaaactc  gccaattct  taacatagc  1200
ggtgtggga  ggatgacac  tggctttga  tttgagtgc  ttttccaga  tactgggaa  1260
gagcttctg  agccttgga  gtattgggt  tgtcaaggt  cacgtgtgc  tttgtaaat  1320
ttcgttctc  atctcattc  tcaggtgat  ggtggtgaa  tgtagctga  ctgaagact  1380
gaactcaat  atcactttt  tgaacaagt  ggaattgtc  tgttactgt  taattggtt  1440
gcttttaag  tgaacaata  attaaataa  ataaaaaaa  aaaaaaaaa  aaa  1493



<210> 362
<211> 208
<212> PRT
<213> Rattus norvegicus
<308> AAC82319
<400> 362

Met Ser Ser Lys Ala Met Leu Lys Val Gln Glu Asp Ile Lys Ala Leu 
  1               5                  10                  15
Lys Gln Leu Leu Ser Leu Ala Ala Ser Gly Leu Gln Arg Asn Thr Leu 
             20                  25                  30
Asn Ile Asp Lys Leu Lys Leu Glu Thr Ala Gln Glu Leu Lys Asn Ala 
         35                  40                  45
Glu Ile Ala Leu Arg Thr Gln Lys Thr Pro Pro Gly Leu Gln His Glu 
     50                  55                  60
Asn Thr Ala Ser Pro Asp Asp Glu Arg Leu Gln Val His Gln Phe Glu 
 65                  70                  75                  80
Val Gln Leu Gln Gln Tyr Arg Gln Gln Ile Glu Glu Leu Glu Asn His 
                 85                  90                  95
Leu Ala Thr Gln Ala Asn Asn Ser His Ile Thr Pro Gln Asp Leu Ser 
             100                105                110
Met Ala Met Gln Lys Ile Tyr Gln Thr Phe Val Ala Leu Ala Ala Gln 
         115                120                125
Leu Gln Ser Ile His Glu Asn Val Lys Val Leu Lys Glu Gln Tyr Leu 
     130                135                140
Ser Tyr Arg Lys Met Phe Leu Gly Asp Ala Gly Asp Val Phe Glu Ala 
 145                150                155                160
Arg Arg Thr Glu Ala Lys Lys Trp Gln Asn Ala Pro Arg Val Thr Thr 
                 165                170                175
Gly Pro Thr Pro Phe Ser Thr Met Pro Asn Ala Ala Ala Val Ala Met 
             180                185                190
Ala Ala Thr Leu Thr Gln Gln Gln Gln Pro Ala Thr Gly Asp Gly Trp 
         195                200                205



<210> 363
<211> 1493
<212> DNA
<213> Rattus norvegicus
<308> AF000899
<400> 363

ggaaacttt  gtaaaatgt  tctttacat  gaaatttca  tttaggcaa  cattggtct  60
tattattga  ttgatttta  ttgtagaac  aagagcccc  cattgagtg  ctattcaga  120
ttcaaagtg  ctcgaattg  ttacatagc  tctacctga  ggatttaga  tctgttttc  180
gatagcaaa  ctaatatat  tggtggcca  agtataact  tgttcatac  ttggcctgg  240
agataattt  tcatgagct  ttactattt  aaatgttac  catttgcct  ctattttat  300
aatgatgtt  ccttcagaa  ttgtgggaa  gtagaaaac  caaaatatc  cgcatcttt  360
gtgcaatgg  aagtcttga  ttttgatgt  ctaaatatg  ttgcagaaa  tgttctgtt  420
ctcttaaaa  atggaccta  atatgacaa  aatccatgc  atctgggta  ttctcccaa  480
ctgtaaggc  gaggactgt  gtgtgcgtt  ttctttagt  tcttccacc  gcagtgcct  540
ctgttaaaa  gtgacagtc  cccaatgtt  aagaaactg  acatatgct  tctctgtta  600
tcttgttag  cataagaaa  taatatgtt  cttttcctg  tgtaacatt  tacaaaaga  660
ctgctagtc  gatctttat  cttaaatta  tctcaaact  gatgtaaaa  tttaaaaat  720
ttttttaat  tattttttt  atagtagta  aagaactct  gctgctact  agttgttat  780
ctgttttcc  gatagaagc  atttaaaaa  gtccagttt  tgtcccagg  tagcaaaat  840
tacttcctc  ttttgttgt  ttgtgattt  taaattaca  taccttttg  atatacaaa  900
ctcattctt  attggacaa  gtgaaggct  tgggttttt  gaagttaaa  ttgaaggtg  960
agtttgctt  ggcattccc  cagctctaa  atgtattaa  cactgtgct  gcagaggcc  1020
ggactaaga  tgtactatg  aacttactg  gtacttttc  caaattatt  tcaaaggag  1080
gatttttag  tttttgtat  ctgcttagt  taaaaaaaa  aaaagagta  tttccacga  1140
gggttagtg  atttgatgc  gttgctgcc  aacaaactc  gccaattct  taacatagc  1200
ggtgtggga  ggatgacac  tggctttga  tttgagtgc  ttttccaga  tactgggaa  1260
gagcttctg  agccttgga  gtattgggt  tgtcaaggt  cacgtgtgc  tttgtaaat  1320
ttcgttctc  atctcattc  tcaggtgat  ggtggtgaa  tgtagctga  ctgaagact  1380
gaactcaat  atcactttt  tgaacaagt  ggaattgtc  tgttactgt  taattggtt  1440
gcttttaag  tgaacaata  attaaataa  ataaaaaaa  aaaaaaaaa  aaa  1493



<210> 364
<211> 208
<212> PRT
<213> Rattus norvegicus
<308> AAC82319
<400> 364

Met Ser Ser Lys Ala Met Leu Lys Val Gln Glu Asp Ile Lys Ala Leu 
  1               5                  10                  15
Lys Gln Leu Leu Ser Leu Ala Ala Ser Gly Leu Gln Arg Asn Thr Leu 
             20                  25                  30
Asn Ile Asp Lys Leu Lys Leu Glu Thr Ala Gln Glu Leu Lys Asn Ala 
         35                  40                  45
Glu Ile Ala Leu Arg Thr Gln Lys Thr Pro Pro Gly Leu Gln His Glu 
     50                  55                  60
Asn Thr Ala Ser Pro Asp Asp Glu Arg Leu Gln Val His Gln Phe Glu 
 65                  70                  75                  80
Val Gln Leu Gln Gln Tyr Arg Gln Gln Ile Glu Glu Leu Glu Asn His 
                 85                  90                  95
Leu Ala Thr Gln Ala Asn Asn Ser His Ile Thr Pro Gln Asp Leu Ser 
             100                105                110
Met Ala Met Gln Lys Ile Tyr Gln Thr Phe Val Ala Leu Ala Ala Gln 
         115                120                125
Leu Gln Ser Ile His Glu Asn Val Lys Val Leu Lys Glu Gln Tyr Leu 
     130                135                140
Ser Tyr Arg Lys Met Phe Leu Gly Asp Ala Gly Asp Val Phe Glu Ala 
 145                150                155                160
Arg Arg Thr Glu Ala Lys Lys Trp Gln Asn Ala Pro Arg Val Thr Thr 
                 165                170                175
Gly Pro Thr Pro Phe Ser Thr Met Pro Asn Ala Ala Ala Val Ala Met 
             180                185                190
Ala Ala Thr Leu Thr Gln Gln Gln Gln Pro Ala Thr Gly Asp Gly Trp 
         195                200                205



<210> 365
<211> 1493
<212> DNA
<213> Rattus norvegicus
<308> AF000899
<400> 365

ggaaacttt  gtaaaatgt  tctttacat  gaaatttca  tttaggcaa  cattggtct  60
tattattga  ttgatttta  ttgtagaac  aagagcccc  cattgagtg  ctattcaga  120
ttcaaagtg  ctcgaattg  ttacatagc  tctacctga  ggatttaga  tctgttttc  180
gatagcaaa  ctaatatat  tggtggcca  agtataact  tgttcatac  ttggcctgg  240
agataattt  tcatgagct  ttactattt  aaatgttac  catttgcct  ctattttat  300
aatgatgtt  ccttcagaa  ttgtgggaa  gtagaaaac  caaaatatc  cgcatcttt  360
gtgcaatgg  aagtcttga  ttttgatgt  ctaaatatg  ttgcagaaa  tgttctgtt  420
ctcttaaaa  atggaccta  atatgacaa  aatccatgc  atctgggta  ttctcccaa  480
ctgtaaggc  gaggactgt  gtgtgcgtt  ttctttagt  tcttccacc  gcagtgcct  540
ctgttaaaa  gtgacagtc  cccaatgtt  aagaaactg  acatatgct  tctctgtta  600
tcttgttag  cataagaaa  taatatgtt  cttttcctg  tgtaacatt  tacaaaaga  660
ctgctagtc  gatctttat  cttaaatta  tctcaaact  gatgtaaaa  tttaaaaat  720
ttttttaat  tattttttt  atagtagta  aagaactct  gctgctact  agttgttat  780
ctgttttcc  gatagaagc  atttaaaaa  gtccagttt  tgtcccagg  tagcaaaat  840
tacttcctc  ttttgttgt  ttgtgattt  taaattaca  taccttttg  atatacaaa  900
ctcattctt  attggacaa  gtgaaggct  tgggttttt  gaagttaaa  ttgaaggtg  960
agtttgctt  ggcattccc  cagctctaa  atgtattaa  cactgtgct  gcagaggcc  1020
ggactaaga  tgtactatg  aacttactg  gtacttttc  caaattatt  tcaaaggag  1080
gatttttag  tttttgtat  ctgcttagt  taaaaaaaa  aaaagagta  tttccacga  1140
gggttagtg  atttgatgc  gttgctgcc  aacaaactc  gccaattct  taacatagc  1200
ggtgtggga  ggatgacac  tggctttga  tttgagtgc  ttttccaga  tactgggaa  1260
gagcttctg  agccttgga  gtattgggt  tgtcaaggt  cacgtgtgc  tttgtaaat  1320
ttcgttctc  atctcattc  tcaggtgat  ggtggtgaa  tgtagctga  ctgaagact  1380
gaactcaat  atcactttt  tgaacaagt  ggaattgtc  tgttactgt  taattggtt  1440
gcttttaag  tgaacaata  attaaataa  ataaaaaaa  aaaaaaaaa  aaa  1493



<210> 366
<211> 208
<212> PRT
<213> Rattus norvegicus
<308> AAC82319
<400> 366

Met Ser Ser Lys Ala Met Leu Lys Val Gln Glu Asp Ile Lys Ala Leu 
  1               5                  10                  15
Lys Gln Leu Leu Ser Leu Ala Ala Ser Gly Leu Gln Arg Asn Thr Leu 
             20                  25                  30
Asn Ile Asp Lys Leu Lys Leu Glu Thr Ala Gln Glu Leu Lys Asn Ala 
         35                  40                  45
Glu Ile Ala Leu Arg Thr Gln Lys Thr Pro Pro Gly Leu Gln His Glu 
     50                  55                  60
Asn Thr Ala Ser Pro Asp Asp Glu Arg Leu Gln Val His Gln Phe Glu 
 65                  70                  75                  80
Val Gln Leu Gln Gln Tyr Arg Gln Gln Ile Glu Glu Leu Glu Asn His 
                 85                  90                  95
Leu Ala Thr Gln Ala Asn Asn Ser His Ile Thr Pro Gln Asp Leu Ser 
             100                105                110
Met Ala Met Gln Lys Ile Tyr Gln Thr Phe Val Ala Leu Ala Ala Gln 
         115                120                125
Leu Gln Ser Ile His Glu Asn Val Lys Val Leu Lys Glu Gln Tyr Leu 
     130                135                140
Ser Tyr Arg Lys Met Phe Leu Gly Asp Ala Gly Asp Val Phe Glu Ala 
 145                150                155                160
Arg Arg Thr Glu Ala Lys Lys Trp Gln Asn Ala Pro Arg Val Thr Thr 
                 165                170                175
Gly Pro Thr Pro Phe Ser Thr Met Pro Asn Ala Ala Ala Val Ala Met 
             180                185                190
Ala Ala Thr Leu Thr Gln Gln Gln Gln Pro Ala Thr Gly Asp Gly Trp 
         195                200                205



<210> 367
<211> 1493
<212> DNA
<213> Rattus norvegicus
<308> AF000899
<400> 367

ggaaacttt  gtaaaatgt  tctttacat  gaaatttca  tttaggcaa  cattggtct  60
tattattga  ttgatttta  ttgtagaac  aagagcccc  cattgagtg  ctattcaga  120
ttcaaagtg  ctcgaattg  ttacatagc  tctacctga  ggatttaga  tctgttttc  180
gatagcaaa  ctaatatat  tggtggcca  agtataact  tgttcatac  ttggcctgg  240
agataattt  tcatgagct  ttactattt  aaatgttac  catttgcct  ctattttat  300
aatgatgtt  ccttcagaa  ttgtgggaa  gtagaaaac  caaaatatc  cgcatcttt  360
gtgcaatgg  aagtcttga  ttttgatgt  ctaaatatg  ttgcagaaa  tgttctgtt  420
ctcttaaaa  atggaccta  atatgacaa  aatccatgc  atctgggta  ttctcccaa  480
ctgtaaggc  gaggactgt  gtgtgcgtt  ttctttagt  tcttccacc  gcagtgcct  540
ctgttaaaa  gtgacagtc  cccaatgtt  aagaaactg  acatatgct  tctctgtta  600
tcttgttag  cataagaaa  taatatgtt  cttttcctg  tgtaacatt  tacaaaaga  660
ctgctagtc  gatctttat  cttaaatta  tctcaaact  gatgtaaaa  tttaaaaat  720
ttttttaat  tattttttt  atagtagta  aagaactct  gctgctact  agttgttat  780
ctgttttcc  gatagaagc  atttaaaaa  gtccagttt  tgtcccagg  tagcaaaat  840
tacttcctc  ttttgttgt  ttgtgattt  taaattaca  taccttttg  atatacaaa  900
ctcattctt  attggacaa  gtgaaggct  tgggttttt  gaagttaaa  ttgaaggtg  960
agtttgctt  ggcattccc  cagctctaa  atgtattaa  cactgtgct  gcagaggcc  1020
ggactaaga  tgtactatg  aacttactg  gtacttttc  caaattatt  tcaaaggag  1080
gatttttag  tttttgtat  ctgcttagt  taaaaaaaa  aaaagagta  tttccacga  1140
gggttagtg  atttgatgc  gttgctgcc  aacaaactc  gccaattct  taacatagc  1200
ggtgtggga  ggatgacac  tggctttga  tttgagtgc  ttttccaga  tactgggaa  1260
gagcttctg  agccttgga  gtattgggt  tgtcaaggt  cacgtgtgc  tttgtaaat  1320
ttcgttctc  atctcattc  tcaggtgat  ggtggtgaa  tgtagctga  ctgaagact  1380
gaactcaat  atcactttt  tgaacaagt  ggaattgtc  tgttactgt  taattggtt  1440
gcttttaag  tgaacaata  attaaataa  ataaaaaaa  aaaaaaaaa  aaa  1493



<210> 368
<211> 208
<212> PRT
<213> Rattus norvegicus
<308> AAC82319
<400> 368

Met Ser Ser Lys Ala Met Leu Lys Val Gln Glu Asp Ile Lys Ala Leu 
  1               5                  10                  15
Lys Gln Leu Leu Ser Leu Ala Ala Ser Gly Leu Gln Arg Asn Thr Leu 
             20                  25                  30
Asn Ile Asp Lys Leu Lys Leu Glu Thr Ala Gln Glu Leu Lys Asn Ala 
         35                  40                  45
Glu Ile Ala Leu Arg Thr Gln Lys Thr Pro Pro Gly Leu Gln His Glu 
     50                  55                  60
Asn Thr Ala Ser Pro Asp Asp Glu Arg Leu Gln Val His Gln Phe Glu 
 65                  70                  75                  80
Val Gln Leu Gln Gln Tyr Arg Gln Gln Ile Glu Glu Leu Glu Asn His 
                 85                  90                  95
Leu Ala Thr Gln Ala Asn Asn Ser His Ile Thr Pro Gln Asp Leu Ser 
             100                105                110
Met Ala Met Gln Lys Ile Tyr Gln Thr Phe Val Ala Leu Ala Ala Gln 
         115                120                125
Leu Gln Ser Ile His Glu Asn Val Lys Val Leu Lys Glu Gln Tyr Leu 
     130                135                140
Ser Tyr Arg Lys Met Phe Leu Gly Asp Ala Gly Asp Val Phe Glu Ala 
 145                150                155                160
Arg Arg Thr Glu Ala Lys Lys Trp Gln Asn Ala Pro Arg Val Thr Thr 
                 165                170                175
Gly Pro Thr Pro Phe Ser Thr Met Pro Asn Ala Ala Ala Val Ala Met 
             180                185                190
Ala Ala Thr Leu Thr Gln Gln Gln Gln Pro Ala Thr Gly Asp Gly Trp 
         195                200                205



<210> 369
<211> 528
<212> DNA
<213> Rattus norvegicus
<308> AF000942
<400> 369

gttcttaaa  tttgctctc  aacctccaa  atgaaggcg  tgagcccgg  gcgcggctg  60
tacgaggcg  tgtgctgcc  gtcggaacg  agcctagcc  ttgcgcgag  ccggggtaa  120
agcccgtcg  cggaggagc  gcttagcct  ttggacgac  tgaaccact  ctactcgcg  180
ctgcgggaa  tggtgccgg  agtcccgcg  ggcactcag  ttagccagg  ggaaatcct  240
cagcgtgtc  tagactaca  cctcgacct  caagtggtt  tggcagagc  cgcgcctgg  300
cccccggat  gtccgcatc  cccgatcca  gtacgagag  gagctagac  aggctcatc  360
gaacgtgcg  gctgggatg  tgcgggtct  ccccaccgc  tcctcgagt  ccttggcta  420
ctcgtctct  atccttctt  cacagacag  tgagctcac  ccggaactt  tgatctcca  480
ggacaagag  agtttttgc  actgacccg  tcgtcctgg  acctcccg  528



<210> 370
<211> 119
<212> PRT
<213> Rattus norvegicus
<308> P41138
<400> 370

Met Lys Ala Leu Ser Pro Val Arg Gly Cys Tyr Glu Ala Val Cys Cys 
  1               5                  10                  15
Leu Ser Glu Arg Ser Leu Ala Ile Ala Arg Gly Arg Gly Lys Ser Pro 
             20                  25                  30
Ser Ala Glu Glu Pro Leu Ser Leu Leu Asp Asp Met Asn His Cys Tyr 
         35                  40                  45
Ser Arg Leu Arg Glu Leu Val Pro Gly Val Pro Arg Gly Thr Gln Leu 
     50                  55                  60
Ser Gln Val Glu Ile Leu Gln Arg Val Ile Asp Tyr Ile Leu Asp Leu 
 65                  70                  75                  80
Gln Val Val Leu Ala Glu Pro Ala Pro Gly Pro Pro Asp Gly Pro His 
                 85                  90                  95
Leu Pro Ile Gln Thr Ala Glu Leu Thr Pro Glu Leu Val Ile Ser Lys 
             100                105                110
Asp Lys Arg Ser Phe Cys His 
         115



<210> 371
<211> 982
<212> DNA
<213> Homo sapiens
<308> X66924
<400> 371

agacaattt  cagcaggaa  aagtagaaa  gataaaatg  atcctgcac  acgggaacc  60
cacagcacc  cacttcttt  ggttttctt  ctctttggg  cacctctgg  ctcactccc  120
agcatgaag  cgctgagcc  ggtgcgcgg  tgctacgag  cggtgtgct  cctgtcgga  180
cgcagtctg  ccatcgccc  gggccgagg  aagggcccg  cagctgagg  gccgctgag  240
ttgctggac  acatgaacc  ctgctactc  cgcctgcgg  aactggtac  cggagtccc  300
agaggcact  agcttagcc  ggtggaaat  ctacagcgc  tcatcgact  cattctcga  360
ctgcaggta  tcctggccg  gccagcccc  ggaccccct  atggccccc  ccttcccat  420
cagacagcc  agctcgctc  ggaacttgt  atctccaac  acaaaagga  cttttgcca  480
tgactcggc  gtgtcctga  acctccaga  cgcaggtgc  ggcgcccgt  ctgcctggg  540
ccccgggaa  ctctcctgc  ggaagccgg  cggcaggga  gggccccaa  ttcgccctg  600
ccacttgac  tcaccaaat  ccttcctgg  gactgaacc  ggtgctcag  agcgaagga  660
tgtgaactt  tggcctgaa  agccagagc  agctctggc  accagctgg  cgacgtcac  720
ctgctccca  cccacccca  gttctaagg  cttttcaga  cgtggaggt  tggaaggag  780
ggctgctct  caaactatg  caaggcggc  gcagagctg  tcttctggt  tccttggag  840
aaggttctg  tgccctgat  tatgaactc  ataatagag  atataggtt  tgtaccttt  900
ttacaggaa  gtgactttc  gtaacaatg  gatgtatat  aaacttttt  taaaagtta  960
cattttgca  aataaacga  tt  982



<210> 372
<211> 119
<212> PRT
<213> Homo sapiens
<308> Q02535
<400> 372

Met Lys Ala Leu Ser Pro Val Arg Gly Cys Tyr Glu Ala Val Cys Cys 
  1               5                  10                  15
Leu Ser Glu Arg Ser Leu Ala Ile Ala Arg Gly Arg Gly Lys Gly Pro 
             20                  25                  30
Ala Ala Glu Glu Pro Leu Ser Leu Leu Asp Asp Met Asn His Cys Tyr 
         35                  40                  45
Ser Arg Leu Arg Glu Leu Val Pro Gly Val Pro Arg Gly Thr Gln Leu 
     50                  55                  60
Ser Gln Val Glu Ile Leu Gln Arg Val Ile Asp Tyr Ile Leu Asp Leu 
 65                  70                  75                  80
Gln Val Val Leu Ala Glu Pro Ala Pro Gly Pro Pro Asp Gly Pro His 
                 85                  90                  95
Leu Pro Ile Gln Thr Ala Glu Leu Ala Pro Glu Leu Val Ile Ser Asn 
             100                105                110
Asp Lys Arg Ser Phe Cys His 
         115



<210> 373
<211> 1356
<212> DNA
<213> Rattus norvegicus
<308> AF001417
<400> 373

ggagactgt  ttttccaac  cgacatgga  gtgctccca  tgtgtagca  cttccagga  60
ctacagatt  tgcacgaaa  gggctactt  tcggctctg  cgtccctgg  ggaatattg  120
caacagacc  gcctggagt  ggaacgcta  cttcagagt  agccctgct  cgtgtcagc  180
tctgagata  aatttgaca  ccaggaaga  ctgtggacc  aaatcattc  agcacggga  240
aggaaggag  aatcagaac  gaagatttc  tctagtccc  cagaggact  tctgatcag  300
tccggcttt  attataact  agagaccaa  agcctgaac  ctgatgtca  cagcgaatc  360
tcagacagt  cggaggaac  ttcgcccac  accaagttt  cctctgacc  cattggtga  420
gtcttagtc  attcaggaa  tctgagttc  tcggtcatt  ccacacctc  ttcttctcc  480
gaagtaaat  gggaatctt  tcaactatg  ggctgtggg  caggagacc  gccctcacc  540
gggaaggtt  gaagtggga  ctcggggaa  tctggcgac  agggtagtg  cgacgcctc  600
ccagatggc  gaagaaggg  acatcggtg  cattttaac  gctgcagga  agtttacac  660
aaaagctcc  acttgaaag  acatcagcg  actcacaca  gagaaaagc  ttacagatg  720
tcttgggaa  gttgtgagt  gcgttttgc  agaagtgat  agttgacca  acacttccg  780
aagcatact  gtgccaagc  ctttaaatg  tctcactgt  acaggtgtt  ctccaggtc  840
gaccacctg  ccctgcaca  gaagaggca  ctctgaggg  gcagaggat  aatcctgta  900
gctaaaaga  gcttccagg  taagaggcg  ccatggaag  agggatacc  gtaccagcc  960
aagcatgcc  ttgcttcct  cccagttac  tccagaggc  tctctttgg  aggtctttt  1020
agggctaca  aagtcatgt  agaagcggc  tagcaccca  ggtgcatgg  gtttgggtg  1080
ccccggact  accactggt  tctaacctt  tgagaggct  taagctttt  gccgtgagc  1140
tgcgcactg  gaatgttaa  gggtgggaa  gactgactg  atgttgagg  tctattact  1200
actgtatgg  gaggcagac  ttttttttc  ccccttgtg  tagcaaata  ctgcaagag  1260
cagaaaaaa  aagcagttt  aatgttttg  gtgtgagga  tattccaag  gatgagttg  1320
ccaccaatc  tttcctgaa  ggtgtctgc  ccttag  1356



<210> 374
<211> 283
<212> PRT
<213> Rattus norvegicus
<308> O35819
<400> 374

Met Asp Val Leu Pro Met Cys Ser Ile Phe Gln Glu Leu Gln Ile Val 
  1               5                  10                  15
His Glu Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Tyr Trp 
             20                  25                  30
Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Ser Glu Pro Cys 
         35                  40                  45
Tyr Val Ser Ala Ser Glu Ile Lys Phe Asp Asn Gln Glu Asp Leu Trp 
     50                  55                  60
Thr Lys Ile Ile Leu Ala Arg Glu Arg Lys Glu Glu Ser Glu Leu Lys 
 65                  70                  75                  80
Ile Ser Ser Ser Pro Pro Glu Asp Ser Leu Ile Ser Ser Gly Phe Asn 
                 85                  90                  95
Tyr Asn Leu Glu Thr Asn Ser Leu Asn Ser Asp Val Ser Ser Glu Ser 
             100                105                110
Ser Asp Ser Ser Glu Glu Leu Ser Pro Thr Thr Lys Phe Thr Ser Asp 
         115                120                125
Pro Ile Gly Glu Val Leu Val Asn Ser Gly Asn Leu Ser Ser Ser Val 
     130                135                140
Ile Ser Thr Pro Pro Ser Ser Pro Glu Val Asn Arg Glu Ser Ser Gln 
 145                150                155                160
Leu Trp Gly Cys Gly Pro Gly Asp Leu Pro Ser Pro Gly Lys Val Arg 
                 165                170                175
Ser Gly Thr Ser Gly Lys Ser Gly Asp Lys Gly Ser Gly Asp Ala Ser 
             180                185                190
Pro Asp Gly Arg Arg Arg Val His Arg Cys His Phe Asn Gly Cys Arg 
         195                200                205
Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala His Gln Arg Thr His 
     210                215                220
Thr Gly Glu Lys Pro Tyr Arg Cys Ser Trp Glu Gly Cys Glu Trp Arg 
 225                230                235                240
Phe Ala Arg Ser Asp Glu Leu Thr Arg His Phe Arg Lys His Thr Gly 
                 245                250                255
Ala Lys Pro Phe Lys Cys Ser His Cys Asp Arg Cys Phe Ser Arg Ser 
             260                265                270
Asp His Leu Ala Leu His Met Lys Arg His Leu 
         275                280



<210> 375
<211> 1350
<212> DNA
<213> Homo sapiens
<308> U44975
<400> 375

gggcgggca  cccggcccg  catggacgt  ctccccatg  gcagcatct  ccaggagct  60
cagatcgtg  acgagaccg  ctacttctc  gcgctgccg  ctctggagg  gtactggca  120
cagacctgc  tagagctgg  acgttacct  cagagcgag  cctgctatg  ttcagcctc  180
gaaatcaaa  ttgacagcc  ggaagatct  tggaccaaa  tcattctgg  tcgggagaa  240
aaggaggaa  ccgaactga  gatatcttc  agtcctcca  aggacactc  catcagccc  300
agcttttgt  acaacttag  gaccaacag  ctgaactca  atgtcagca  cgaatcctc  360
gacagctcc  aggaacttt  tcccacggc  aagtttacc  ccgacccca  tggcgaagt  420
ttggtcagc  cgggaaaat  gagctcctc  gtcacctcc  cgcctccat  ttctccgga  480
ctgagcagg  aaccttctc  actgtgggg  tgcgtgccc  gggagctgc  ctcgccagg  540
aaggtgcgc  gcgggactt  ggggaagcc  ggtgacaag  gaaatggcg  tgcctcccc  600
gacggcagg  ggagggtgc  ccggtgcca  tttaacggc  gcaggaaag  ttacaccaa  660
agctcccac  tgaaagcac  ccagcggac  cacacagga  aaaagcctt  cagatgctc  720
tgggaaggg  gtgagtggc  ttttgcaag  agtgatgag  taaccaggc  cttccgaaa  780
cacaccggg  ccaagcctt  taaatgctc  cactgtgac  ggtgttttt  caggtctga  840
cacctggcc  tgcacatga  gaggcacct  tgagggagc  gagaggtgg  tcctgtagg  900
taaaaggct  ccaggctga  agccggccg  ggaaggagg  atgcgtggt  ccagccaaa  960
catgccgtt  tgcacccta  ccagttgcc  ccagggcct  tccttggaa  gtcttttga  1020
ggctaaaaa  gtcctgtaa  aagaggcat  gcacccgtg  tggcaatgg  tatgtgggt  1080
accctggac  cgccactgg  acccgccct  ccgagcggc  gcctaagcc  ttgccgtga  1140
atgcacact  agaatgcta  tggttgggt  gattgtatg  tgaggatct  ttactgacc  1200
tatgatgag  ccaactttt  ttccttgtg  ttagcaaga  tgcaaagag  tggaaaaaa  1260
gtagtttga  tgttttgtg  gtaaggagt  taccatgag  tgagatgac  accaatcat  1320
tccttgggg  gagggggtg  ctgccccccc  1350



<210> 376
<211> 283
<212> PRT
<213> Homo sapiens
<308> Q99612
<400> 376

Met Asp Val Leu Pro Met Cys Ser Ile Phe Gln Glu Leu Gln Ile Val 
  1               5                  10                  15
His Glu Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Tyr Trp 
             20                  25                  30
Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Ser Glu Pro Cys 
         35                  40                  45
Tyr Val Ser Ala Ser Glu Ile Lys Phe Asp Ser Gln Glu Asp Leu Trp 
     50                  55                  60
Thr Lys Ile Ile Leu Ala Arg Glu Lys Lys Glu Glu Ser Glu Leu Lys 
 65                  70                  75                  80
Ile Ser Ser Ser Pro Pro Glu Asp Thr Leu Ile Ser Pro Ser Phe Cys 
                 85                  90                  95
Tyr Asn Leu Glu Thr Asn Ser Leu Asn Ser Asp Val Ser Ser Glu Ser 
             100                105                110
Ser Asp Ser Ser Glu Glu Leu Ser Pro Thr Ala Lys Phe Thr Ser Asp 
         115                120                125
Pro Ile Gly Glu Val Leu Val Ser Ser Gly Lys Leu Ser Ser Ser Val 
     130                135                140
Thr Ser Thr Pro Pro Ser Ser Pro Glu Leu Ser Arg Glu Pro Ser Gln 
 145                150                155                160
Leu Trp Gly Cys Val Pro Gly Glu Leu Pro Ser Pro Gly Lys Val Arg 
                 165                170                175
Ser Gly Thr Ser Gly Lys Pro Gly Asp Lys Gly Asn Gly Asp Ala Ser 
             180                185                190
Pro Asp Gly Arg Arg Arg Val His Arg Cys His Phe Asn Gly Cys Arg 
         195                200                205
Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala His Gln Arg Thr His 
     210                215                220
Thr Gly Glu Lys Pro Tyr Arg Cys Ser Trp Glu Gly Cys Glu Trp Arg 
 225                230                235                240
Phe Ala Arg Ser Asp Glu Leu Thr Arg His Phe Arg Lys His Thr Gly 
                 245                250                255
Ala Lys Pro Phe Lys Cys Ser His Cys Asp Arg Cys Phe Ser Arg Ser 
             260                265                270
Asp His Leu Ala Leu His Met Lys Arg His Leu 
         275                280



<210> 377
<211> 1059
<212> DNA
<213> Rattus norvegicus
<308> AF001953
<400> 377

atggcaacc  atgggctgc  cgagaacga  acgctggcg  cgctgaaga  cgaggccga  60
agcctcaag  gcaagctag  ggaggagcg  gcgaagctg  atgacgtgg  gcttcacca  120
gtggccgag  gggtggagg  cctgggcca  tttgtcatg  agaccagaa  gaccctcaa  180
ggacacggg  acaaagtcc  gtgcatgga  tggtgcaaa  acaagcgga  gatcgtgag  240
tcctcacag  atgggaagg  gattgtctg  gattccttc  ctactaaca  ggagcacgc  300
gtcaccatg  cttgcacct  ggtgatggc  tgtgcttat  ccccatcag  atgtgccat  360
gcttgtggt  gtctggata  taagtgttc  gtgtaccca  tgacatttg  caagaacga  420
aacatggct  ccaagaaga  gtctgtcgc  atgcacacc  actacctgt  tgcctgcag  480
ttcaccaac  cagacatgc  gatcctgac  gccagcggt  atggcactt  cgccctgtg  540
gatgtggaa  gtggacagc  gttgcagag  ttccatggc  atggggctg  cgtcctctg  600
ttggacctg  ccccctcag  aactggaaa  accttcgtg  ctgggggtt  tgacaagaa  660
gccatggtg  gggacatgc  ctctggcca  tgtgtgcaa  cctttgaaa  tcatgaatc  720
gatgtcaac  gtgtccgat  ctaccccag  ggagatgct  ttgcttccg  atcagatga  780
gccacgtgt  gcctctatg  cctgagggc  gatagagag  ttgccattt  ctccaagga  840
agtattata  ttggagcat  aagcgtgga  ttctccctc  gtggccgcc  gctctttgc  900
gggtacaat  actatacca  caatgtctg  gatgttctc  agggctccc  ggtctccat  960
ctgtttgga  atgaaaacc  tgttagcac  ctgcgagtg  ctcctgatg  gacagcatt  1020
tgctcaggg  cgtgggatc  caccctaag  gtttgggca  1059



<210> 378
<211> 353
<212> PRT
<213> Rattus norvegicus
<308> AAB59974
<400> 378

Met Ala Thr Asp Gly Leu His Glu Asn Glu Thr Leu Ala Ser Leu Lys 
  1               5                  10                  15
Ser Glu Ala Glu Ser Leu Lys Gly Lys Leu Glu Glu Glu Arg Ala Lys 
             20                  25                  30
Leu His Asp Val Glu Leu His Gln Val Ala Glu Arg Val Glu Ala Leu 
         35                  40                  45
Gly Gln Phe Val Met Lys Thr Arg Arg Thr Leu Lys Gly His Gly Asn 
     50                  55                  60
Lys Val Leu Cys Met Asp Trp Cys Lys Asp Lys Arg Arg Ile Val Ser 
 65                  70                  75                  80
Ser Ser Gln Asp Gly Lys Val Ile Val Trp Asp Ser Phe Thr Thr Asn 
                 85                  90                  95
Lys Glu His Ala Val Thr Met Pro Cys Thr Trp Val Met Ala Cys Ala 
             100                105                110
Tyr Ala Pro Ser Gly Cys Ala Ile Ala Cys Gly Gly Leu Asp Asn Lys 
         115                120                125
Cys Ser Val Tyr Pro Leu Thr Phe Asp Lys Asn Glu Asn Met Ala Ala 
     130                135                140
Lys Lys Lys Ser Val Ala Met His Thr Asn Tyr Leu Ser Ala Cys Ser 
 145                150                155                160
Phe Thr Asn Ser Asp Met Gln Ile Leu Thr Ala Ser Gly Asp Gly Thr 
                 165                170                175
Cys Ala Leu Trp Asp Val Glu Ser Gly Gln Leu Leu Gln Ser Phe His 
             180                185                190
Gly His Gly Ala Asp Val Leu Cys Leu Asp Leu Ala Pro Ser Glu Thr 
         195                200                205
Gly Asn Thr Phe Val Ser Gly Gly Cys Asp Lys Lys Ala Met Val Trp 
     210                215                220
Asp Met Arg Ser Gly Gln Cys Val Gln Ala Phe Glu Thr His Glu Ser 
 225                230                235                240
Asp Val Asn Ser Val Arg Tyr Tyr Pro Ser Gly Asp Ala Phe Ala Ser 
                 245                250                255
Gly Ser Asp Asp Ala Thr Cys Arg Leu Tyr Asp Leu Arg Ala Asp Arg 
             260                265                270
Glu Val Ala Ile Tyr Ser Lys Glu Ser Ile Ile Phe Gly Ala Ser Ser 
         275                280                285
Val Asp Phe Ser Leu Ser Gly Arg Leu Leu Phe Ala Gly Tyr Asn Asp 
     290                295                300
Tyr Thr Ile Asn Val Trp Asp Val Leu Lys Gly Ser Arg Val Ser Ile 
 305                310                315                320
Leu Phe Gly His Glu Asn Arg Val Ser Thr Leu Arg Val Ser Pro Asp 
                 325                330                335
Gly Thr Ala Phe Cys Ser Gly Ser Trp Asp His Thr Leu Arg Val Trp 
             340                345                350
Ala 
         355



<210> 379
<211> 1188
<212> DNA
<213> Homo sapiens
<308> AF300650
<400> 379

atgtgtgat  agacctttc  cgttaatgt  tttggctca  gtgacaaat  tttcaaaca  60
cgagctctg  gaccagttt  caagaagtc  caacaactc  gctactgtt  aacatgtgc  120
gaaattatg  caaccgagg  gctgcacga  aacgagacg  tggcgtcgc  gaagagcga  180
gccgagagc  tcaagggca  gctggagga  gagcgagcc  agctgcacg  tgtggagct  240
caccaggtg  cggagcggg  ggaggccct  gggcagttt  tcatgaaga  cagaaggac  300
ctcaaaggc  acgggaaca  agtcctgtg  atggactgg  gcaaagata  gaggaggat  360
gtgagctcg  cacaggatg  gaaggtgat  gtgtgggat  ccttcacca  aaacaagga  420
cacgcggtc  ccatgccct  cacgtgggt  atggcatgt  cttatgccc  atcgggatg  480
gccattgct  gtggtggtt  ggataataa  tgttctgtg  accccttga  gtttgacaa  540
aatgaaaac  tggctgcca  aaagaagtc  gttgctatg  acaccaact  cctgtcggc  600
tgcagcttc  ccaactctg  catgcagat  ctgacagcg  gcggcgatg  cacatgtgc  660
ctgtgggac  tggagagcg  gcagctgct  cagagcttc  acggacatg  ggctgacgt  720
ctctgcttg  acctggccc  ctcagaaac  ggaaacacc  tcgtgtctg  gggatgtga  780
aagaaagcc  tggtgtggg  catgcgctc  ggccagtgc  tgcaggcct  tgaaacaca  840
gaatctgac  tcaacagtg  ccggtacta  cccagtgga  atgcctttg  ttcagggtc  900
gatgacgct  cgtgtcgcc  ctatgacct  cgggcagat  gggaggttg  catctattc  960
aaagaaagc  tcatatttg  agcatccag  gtggacttc  ccctcagtg  tcgcctgct  1020
tttgctgga  acaatgatt  cactatcaa  gtctgggat  ttctcaaag  gtcccgggt  1080
tccatcctg  ttggacatg  aaaccgcgt  agcactcta  gagtttccc  cgatgggac  1140
gctttctgc  ctggatcat  ggatcatac  ctcagagtc  gggcctaa  1188



<210> 380
<211> 353
<212> PRT
<213> Homo sapiens
<308> O14775
<400> 380

Met Ala Thr Glu Gly Leu His Glu Asn Glu Thr Leu Ala Ser Leu Lys 
  1               5                  10                  15
Ser Glu Ala Glu Ser Leu Lys Gly Lys Leu Glu Glu Glu Arg Ala Lys 
             20                  25                  30
Leu His Asp Val Glu Leu His Gln Val Ala Glu Arg Val Glu Ala Leu 
         35                  40                  45
Gly Gln Phe Val Met Lys Thr Arg Arg Thr Leu Lys Gly His Gly Asn 
     50                  55                  60
Lys Val Leu Cys Met Asp Trp Cys Lys Asp Lys Arg Arg Ile Val Ser 
 65                  70                  75                  80
Ser Ser Gln Asp Gly Lys Val Ile Val Trp Asp Ser Phe Thr Thr Asn 
                 85                  90                  95
Lys Glu His Ala Val Thr Met Pro Cys Thr Trp Val Met Ala Cys Ala 
             100                105                110
Tyr Ala Pro Ser Gly Cys Ala Ile Ala Cys Gly Gly Leu Asp Asn Lys 
         115                120                125
Cys Ser Val Tyr Pro Leu Thr Phe Asp Lys Asn Glu Asn Met Ala Ala 
     130                135                140
Lys Lys Lys Ser Val Ala Met His Thr Asn Tyr Leu Ser Ala Cys Ser 
 145                150                155                160
Phe Thr Asn Ser Asp Met Gln Ile Leu Thr Ala Ser Gly Asp Gly Thr 
                 165                170                175
Cys Ala Leu Trp Asp Val Glu Ser Gly Gln Leu Leu Gln Ser Phe His 
             180                185                190
Gly His Gly Ala Asp Val Leu Cys Leu Asp Leu Ala Pro Ser Glu Thr 
         195                200                205
Gly Asn Thr Phe Val Ser Gly Gly Cys Asp Lys Lys Ala Met Val Trp 
     210                215                220
Asp Met Arg Ser Gly Gln Cys Val Gln Ala Phe Glu Thr His Glu Ser 
 225                230                235                240
Asp Ile Asn Ser Val Arg Tyr Tyr Pro Ser Gly Asp Ala Phe Ala Ser 
                 245                250                255
Gly Ser Asp Asp Ala Thr Cys Arg Leu Tyr Asp Leu Arg Ala Asp Arg 
             260                265                270
Glu Val Ala Ile Tyr Ser Lys Glu Ser Ile Ile Phe Gly Ala Ser Ser 
         275                280                285
Val Asp Phe Ser Leu Ser Gly Arg Leu Leu Phe Ala Gly Tyr Asn Asp 
     290                295                300
Tyr Thr Ile Asn Val Trp Asp Val Leu Lys Gly Ser Arg Val Ser Ile 
 305                310                315                320
Leu Phe Gly His Glu Asn Arg Val Ser Thr Leu Arg Val Ser Pro Asp 
                 325                330                335
Gly Thr Ala Phe Cys Ser Gly Ser Trp Asp His Thr Leu Arg Val Trp 
             340                345                350
Ala 
         355



<210> 381
<211> 1059
<212> DNA
<213> Rattus norvegicus
<308> AF001953
<400> 381

atggcaacc  atgggctgc  cgagaacga  acgctggcg  cgctgaaga  cgaggccga  60
agcctcaag  gcaagctag  ggaggagcg  gcgaagctg  atgacgtgg  gcttcacca  120
gtggccgag  gggtggagg  cctgggcca  tttgtcatg  agaccagaa  gaccctcaa  180
ggacacggg  acaaagtcc  gtgcatgga  tggtgcaaa  acaagcgga  gatcgtgag  240
tcctcacag  atgggaagg  gattgtctg  gattccttc  ctactaaca  ggagcacgc  300
gtcaccatg  cttgcacct  ggtgatggc  tgtgcttat  ccccatcag  atgtgccat  360
gcttgtggt  gtctggata  taagtgttc  gtgtaccca  tgacatttg  caagaacga  420
aacatggct  ccaagaaga  gtctgtcgc  atgcacacc  actacctgt  tgcctgcag  480
ttcaccaac  cagacatgc  gatcctgac  gccagcggt  atggcactt  cgccctgtg  540
gatgtggaa  gtggacagc  gttgcagag  ttccatggc  atggggctg  cgtcctctg  600
ttggacctg  ccccctcag  aactggaaa  accttcgtg  ctgggggtt  tgacaagaa  660
gccatggtg  gggacatgc  ctctggcca  tgtgtgcaa  cctttgaaa  tcatgaatc  720
gatgtcaac  gtgtccgat  ctaccccag  ggagatgct  ttgcttccg  atcagatga  780
gccacgtgt  gcctctatg  cctgagggc  gatagagag  ttgccattt  ctccaagga  840
agtattata  ttggagcat  aagcgtgga  ttctccctc  gtggccgcc  gctctttgc  900
gggtacaat  actatacca  caatgtctg  gatgttctc  agggctccc  ggtctccat  960
ctgtttgga  atgaaaacc  tgttagcac  ctgcgagtg  ctcctgatg  gacagcatt  1020
tgctcaggg  cgtgggatc  caccctaag  gtttgggca  1059



<210> 382
<211> 353
<212> PRT
<213> Rattus norvegicus
<308> AAB59974
<400> 382

Met Ala Thr Asp Gly Leu His Glu Asn Glu Thr Leu Ala Ser Leu Lys 
  1               5                  10                  15
Ser Glu Ala Glu Ser Leu Lys Gly Lys Leu Glu Glu Glu Arg Ala Lys 
             20                  25                  30
Leu His Asp Val Glu Leu His Gln Val Ala Glu Arg Val Glu Ala Leu 
         35                  40                  45
Gly Gln Phe Val Met Lys Thr Arg Arg Thr Leu Lys Gly His Gly Asn 
     50                  55                  60
Lys Val Leu Cys Met Asp Trp Cys Lys Asp Lys Arg Arg Ile Val Ser 
 65                  70                  75                  80
Ser Ser Gln Asp Gly Lys Val Ile Val Trp Asp Ser Phe Thr Thr Asn 
                 85                  90                  95
Lys Glu His Ala Val Thr Met Pro Cys Thr Trp Val Met Ala Cys Ala 
             100                105                110
Tyr Ala Pro Ser Gly Cys Ala Ile Ala Cys Gly Gly Leu Asp Asn Lys 
         115                120                125
Cys Ser Val Tyr Pro Leu Thr Phe Asp Lys Asn Glu Asn Met Ala Ala 
     130                135                140
Lys Lys Lys Ser Val Ala Met His Thr Asn Tyr Leu Ser Ala Cys Ser 
 145                150                155                160
Phe Thr Asn Ser Asp Met Gln Ile Leu Thr Ala Ser Gly Asp Gly Thr 
                 165                170                175
Cys Ala Leu Trp Asp Val Glu Ser Gly Gln Leu Leu Gln Ser Phe His 
             180                185                190
Gly His Gly Ala Asp Val Leu Cys Leu Asp Leu Ala Pro Ser Glu Thr 
         195                200                205
Gly Asn Thr Phe Val Ser Gly Gly Cys Asp Lys Lys Ala Met Val Trp 
     210                215                220
Asp Met Arg Ser Gly Gln Cys Val Gln Ala Phe Glu Thr His Glu Ser 
 225                230                235                240
Asp Val Asn Ser Val Arg Tyr Tyr Pro Ser Gly Asp Ala Phe Ala Ser 
                 245                250                255
Gly Ser Asp Asp Ala Thr Cys Arg Leu Tyr Asp Leu Arg Ala Asp Arg 
             260                265                270
Glu Val Ala Ile Tyr Ser Lys Glu Ser Ile Ile Phe Gly Ala Ser Ser 
         275                280                285
Val Asp Phe Ser Leu Ser Gly Arg Leu Leu Phe Ala Gly Tyr Asn Asp 
     290                295                300
Tyr Thr Ile Asn Val Trp Asp Val Leu Lys Gly Ser Arg Val Ser Ile 
 305                310                315                320
Leu Phe Gly His Glu Asn Arg Val Ser Thr Leu Arg Val Ser Pro Asp 
                 325                330                335
Gly Thr Ala Phe Cys Ser Gly Ser Trp Asp His Thr Leu Arg Val Trp 
             340                345                350
Ala 
         355



<210> 383
<211> 1188
<212> DNA
<213> Homo sapiens
<308> AF300650
<400> 383

atgtgtgat  agacctttc  cgttaatgt  tttggctca  gtgacaaat  tttcaaaca  60
cgagctctg  gaccagttt  caagaagtc  caacaactc  gctactgtt  aacatgtgc  120
gaaattatg  caaccgagg  gctgcacga  aacgagacg  tggcgtcgc  gaagagcga  180
gccgagagc  tcaagggca  gctggagga  gagcgagcc  agctgcacg  tgtggagct  240
caccaggtg  cggagcggg  ggaggccct  gggcagttt  tcatgaaga  cagaaggac  300
ctcaaaggc  acgggaaca  agtcctgtg  atggactgg  gcaaagata  gaggaggat  360
gtgagctcg  cacaggatg  gaaggtgat  gtgtgggat  ccttcacca  aaacaagga  420
cacgcggtc  ccatgccct  cacgtgggt  atggcatgt  cttatgccc  atcgggatg  480
gccattgct  gtggtggtt  ggataataa  tgttctgtg  accccttga  gtttgacaa  540
aatgaaaac  tggctgcca  aaagaagtc  gttgctatg  acaccaact  cctgtcggc  600
tgcagcttc  ccaactctg  catgcagat  ctgacagcg  gcggcgatg  cacatgtgc  660
ctgtgggac  tggagagcg  gcagctgct  cagagcttc  acggacatg  ggctgacgt  720
ctctgcttg  acctggccc  ctcagaaac  ggaaacacc  tcgtgtctg  gggatgtga  780
aagaaagcc  tggtgtggg  catgcgctc  ggccagtgc  tgcaggcct  tgaaacaca  840
gaatctgac  tcaacagtg  ccggtacta  cccagtgga  atgcctttg  ttcagggtc  900
gatgacgct  cgtgtcgcc  ctatgacct  cgggcagat  gggaggttg  catctattc  960
aaagaaagc  tcatatttg  agcatccag  gtggacttc  ccctcagtg  tcgcctgct  1020
tttgctgga  acaatgatt  cactatcaa  gtctgggat  ttctcaaag  gtcccgggt  1080
tccatcctg  ttggacatg  aaaccgcgt  agcactcta  gagtttccc  cgatgggac  1140
gctttctgc  ctggatcat  ggatcatac  ctcagagtc  gggcctaa  1188



<210> 384
<211> 353
<212> PRT
<213> Homo sapiens
<308> O14775
<400> 384

Met Ala Thr Glu Gly Leu His Glu Asn Glu Thr Leu Ala Ser Leu Lys 
  1               5                  10                  15
Ser Glu Ala Glu Ser Leu Lys Gly Lys Leu Glu Glu Glu Arg Ala Lys 
             20                  25                  30
Leu His Asp Val Glu Leu His Gln Val Ala Glu Arg Val Glu Ala Leu 
         35                  40                  45
Gly Gln Phe Val Met Lys Thr Arg Arg Thr Leu Lys Gly His Gly Asn 
     50                  55                  60
Lys Val Leu Cys Met Asp Trp Cys Lys Asp Lys Arg Arg Ile Val Ser 
 65                  70                  75                  80
Ser Ser Gln Asp Gly Lys Val Ile Val Trp Asp Ser Phe Thr Thr Asn 
                 85                  90                  95
Lys Glu His Ala Val Thr Met Pro Cys Thr Trp Val Met Ala Cys Ala 
             100                105                110
Tyr Ala Pro Ser Gly Cys Ala Ile Ala Cys Gly Gly Leu Asp Asn Lys 
         115                120                125
Cys Ser Val Tyr Pro Leu Thr Phe Asp Lys Asn Glu Asn Met Ala Ala 
     130                135                140
Lys Lys Lys Ser Val Ala Met His Thr Asn Tyr Leu Ser Ala Cys Ser 
 145                150                155                160
Phe Thr Asn Ser Asp Met Gln Ile Leu Thr Ala Ser Gly Asp Gly Thr 
                 165                170                175
Cys Ala Leu Trp Asp Val Glu Ser Gly Gln Leu Leu Gln Ser Phe His 
             180                185                190
Gly His Gly Ala Asp Val Leu Cys Leu Asp Leu Ala Pro Ser Glu Thr 
         195                200                205
Gly Asn Thr Phe Val Ser Gly Gly Cys Asp Lys Lys Ala Met Val Trp 
     210                215                220
Asp Met Arg Ser Gly Gln Cys Val Gln Ala Phe Glu Thr His Glu Ser 
 225                230                235                240
Asp Ile Asn Ser Val Arg Tyr Tyr Pro Ser Gly Asp Ala Phe Ala Ser 
                 245                250                255
Gly Ser Asp Asp Ala Thr Cys Arg Leu Tyr Asp Leu Arg Ala Asp Arg 
             260                265                270
Glu Val Ala Ile Tyr Ser Lys Glu Ser Ile Ile Phe Gly Ala Ser Ser 
         275                280                285
Val Asp Phe Ser Leu Ser Gly Arg Leu Leu Phe Ala Gly Tyr Asn Asp 
     290                295                300
Tyr Thr Ile Asn Val Trp Asp Val Leu Lys Gly Ser Arg Val Ser Ile 
 305                310                315                320
Leu Phe Gly His Glu Asn Arg Val Ser Thr Leu Arg Val Ser Pro Asp 
                 325                330                335
Gly Thr Ala Phe Cys Ser Gly Ser Trp Asp His Thr Leu Arg Val Trp 
             340                345                350
Ala 
         355



<210> 385
<211> 3471
<212> DNA
<213> Rattus norvegicus
<308> AF002251
<400> 385

gcctctccg  gggctccgc  ccgccccgc  ccgcccgcg  gctgcgggc  ctttaaaag  60
gcgctcggc  ggagccgcc  cttctgttg  tcaggctct  gagctgctg  cgcctgcgg  120
ccttggcca  ggcgtcccc  gccattggg  agcgtccct  cccgctgct  ctagacccc  180
agccgccgc  gtatctgca  agcctgggt  gcaccgagc  gccaccgcc  gcccggccg  240
gtcgctgta  ccccacggc  ctgatctcc  cgtccgggg  gtcagaggg  cgcggtagc  300
ggaggaatg  ccgggggga  ccggagccc  cgccccggg  ctgccgaca  gctcgccct  360
tccggcccg  tctgcagca  agactgcgg  ggcgacctg  gtcgcaccg  ccccgcgac  420
tgaggagca  cttcgagca  ccgcaggat  cccgcgtct  agccgagag  ggagaggga  480
accgtttcg  ggaattggc  ctccggggt  gcccgggct  gtgtgacct  tgcggacga  540
aggtgctgc  gcaggcgct  cgctgcgct  attgtaaat  cacctgcca  ccagagtgc  600
gcagcctga  ccagctgga  tgcagacag  aggagggcc  tgccctgga  agacagtct  660
cagaaagca  cctcacccc  accttcaac  agaatgtct  taaggctgt  gaggagaca  720
agcacccgc  caccataca  gagatcaag  agaagattg  cagctataa  agccgggag  780
agcactgcc  gggcatgaa  ttgagtgaa  atggcacct  cacaggttt  atcaaagtg  840
atttgaaac  ccgccggcc  gtgacggtg  ctgctggga  tcggcccca  tccatctat  900
atgccatta  ggaagtgaa  cctgcagct  ccacagaca  gcggacatc  ttctacctg  960
cacttgacg  catcaagca  ctacacatt  gcagcagca  cactgtcag  gaggtcatc  1020
aggggctgc  caagaaatt  atggttgtg  acaacccac  gaagtttgc  ctttttaag  1080
ggatacaca  agatggaca  gtgctcttc  agaaactct  catcgctga  tgccctctc  1140
accttcgtc  gctcgctgg  cctgacacc  acgtgctca  ctttgtgct  aaggagaat  1200
aaaccggag  cgtagagtg  gatgccttt  ccattcctg  actccagaa  ttcttaact  1260
tcctggaaa  agaggagca  gacaagatc  atcaactgc  gaagaagta  aacaaattc  1320
ggcagaaac  ggaggaggc  ttacgagag  cccaaggga  gcctgggta  ccagcttac  1380
tcctgtcct  tcagtgccc  ccaatttat  ttgttaatt  ttttgcaat  aacagttat  1440
ctcaaggca  ctctgatgt  tccacctgt  cctgcccag  agttaacag  tgtggcaca  1500
agtctcttc  acgaagtgt  tgtgcaggg  ttgattcct  ctaacccac  acaccatgg  1560
tctggagat  ttccgtctg  gatcagaac  cctgtggaa  gaccagtat  tcccctgtt  1620
aatctgctg  cttttcgga  accaaatgg  tgcctctct  ctcaccaaa  tccaaccaa  1680
caccagctg  caaaaagga  tgaaaggtt  tagagcctg  gttttttct  tggatttag  1740
tctgttcct  tttcttttt  ctgccacac  gagtatatt  atgggtcaa  tgtggcata  1800
tcattttag  taagtcctt  aaagcagga  aatgctcgt  aaaggactg  cgtccttgc  1860
cccaaggtg  ctcctcttc  cttgtgcta  accctcggt  agcctgaga  tccagaagc  1920
acatctctc  ctgcccagc  ggccgcatg  tgcaaacac  gacacacac  cacacatct  1980
tgtgggact  cggcatgtc  cttccagtg  tgctatgct  aaatcttaa  ttaatgttg  2040
cattcttat  ggtttctac  aaagagaaa  cagccattg  cttatcaat  ttagtttcc  2100
gctgagtcg  cagaagtat  acagcaaag  acatccaag  cgctcgtgg  ctgtgcctg  2160
agtgggggc  tctccttgg  cttcagttc  acctccgtc  tccaacttg  gctttaggg  2220
ctccagctg  tgcctgagt  gtagctttg  ttacagtgg  aaggtcctc  aacttggga  2280
tcctttctg  tgggaagca  ggtctgctc  cacagcatg  gcaaacctg  gggcctgac  2340
ttcctggtg  cttcagtgc  tttttgttt  cagagaaaa  agcagggca  gtttgcttg  2400
agctctcct  ctggcttgc  ccagcagga  gtaggtgct  tagagcaag  acaggaggt  2460
tctcagagc  cagggcgac  atcacacac  tctttccca  caagcttcc  gatcaggct  2520
tgactttga  gattcgaaa  tattagact  cactgacag  atcagatta  gactccaac  2580
cttgactaa  tcaaactta  aacaaatta  ccagactat  ccacccagt  gccaggaca  2640
aaagacgct  aatacggag  gagaaaaac  tgtcctttt  gaagaaggc  agtgttcca  2700
tcgagcctc  agaggagac  gctctcatg  tgtgcttgc  tttccacac  cctcgggtt  2760
ttttaagcc  aagcttctc  gtgtagcct  aaaagttcc  tcccagccc  ggctgaggc  2820
acattgctc  tgtcccaga  gaatgccaa  tccctgtca  tccaagttt  cagagctgc  2880
aaagcacca  gagctagcg  ctctgaggc  gtgcatgcc  tagcccctg  ctccctgcc  2940
cctcaggct  agccttaca  tcccctccc  tgagaagtc  cctttctgc  gtgtattac  3000
gggacatac  gaaactcat  cccttcatc  tgcatgtgt  tagcattag  agaaggcat  3060
gctcctgct  caaacactg  gaatgctgc  cagacctcc  tccatggat  gctatttta  3120
ttttgaaca  gaaaaaaaa  tcatgtata  ataaaatgt  tatacatat  tatgtatat  3180
cacatagag  catatagct  tatataaag  aaaggtgtt  attcagaaa  ggatgatca  3240
attcagact  taaagcaca  ttagacccg  gacctctac  gaggttgag  cgctggaaa  3300
gtggagttc  ttaagtctc  gaggggtct  actgctggt  gtgccttct  tggttgtat  3360
gctctgtgg  tggttgttt  gagaatatt  tctttctaa  tgtttttct  atacatggt  3420
tttttgata  caagcttat  gataccgtc  acctcgagg  gggcccgta  c  3471



<210> 386
<211> 413
<212> PRT
<213> Rattus norvegicus
<308> AAB71821
<400> 386

Met Ala Ser Pro Ala Ile Gly Gln Arg Pro Tyr Pro Leu Leu Leu Asp 
  1               5                  10                  15
Pro Glu Pro Pro Arg Tyr Leu Gln Ser Leu Gly Gly Thr Glu Pro Pro 
             20                  25                  30
Pro Pro Ala Arg Pro Arg Arg Cys Ile Pro Thr Ala Leu Ile Ser Ala 
         35                  40                  45
Ser Gly Ala Ser Glu Gly Arg Gly Ser Arg Arg Asn Ala Arg Gly Asp 
     50                  55                  60
Pro Glu Pro Thr Pro Arg Asp Cys Arg His Ala Arg Pro Val Arg Pro 
 65                  70                  75                  80
Gly Leu Gln Gln Arg Leu Arg Arg Arg Pro Gly Ser His Arg Pro Arg 
                 85                  90                  95
Asp Val Arg Ser Ile Phe Glu Gln Pro Gln Asp Pro Arg Val Leu Ala 
             100                105                110
Glu Arg Gly Glu Gly His Arg Phe Ala Glu Leu Ala Leu Arg Gly Gly 
         115                120                125
Pro Gly Trp Cys Asp Leu Cys Gly Arg Glu Val Leu Arg Gln Ala Leu 
     130                135                140
Arg Cys Ala Asn Cys Lys Phe Thr Cys His Pro Glu Cys Arg Ser Leu 
 145                150                155                160
Ile Gln Leu Asp Cys Arg Gln Lys Glu Gly Pro Ala Leu Asp Arg Gln 
                 165                170                175
Ser Pro Glu Ser Thr Leu Thr Pro Thr Phe Asn Lys Asn Val Cys Lys 
             180                185                190
Ala Val Glu Glu Thr Gln His Pro Pro Thr Ile Gln Glu Ile Lys Gln 
         195                200                205
Lys Ile Asp Ser Tyr Asn Ser Arg Glu Lys His Cys Leu Gly Met Lys 
     210                215                220
Leu Ser Glu Asp Gly Thr Tyr Thr Gly Phe Ile Lys Val His Leu Lys 
 225                230                235                240
Leu Arg Arg Pro Val Thr Val Pro Ala Gly Ile Arg Pro Gln Ser Ile 
                 245                250                255
Tyr Asp Ala Ile Lys Glu Val Asn Pro Ala Ala Thr Thr Asp Lys Arg 
             260                265                270
Thr Ser Phe Tyr Leu Pro Leu Asp Ala Ile Lys Gln Leu His Ile Ser 
         275                280                285
Ser Ser Thr Thr Val Ser Glu Val Ile Gln Gly Leu Leu Lys Lys Phe 
     290                295                300
Met Val Val Asp Asn Pro Gln Lys Phe Ala Leu Phe Lys Arg Ile His 
 305                310                315                320
Lys Asp Gly Gln Val Leu Phe Gln Lys Leu Ser Ile Ala Asp Cys Pro 
                 325                330                335
Leu Tyr Leu Arg Leu Leu Ala Gly Pro Asp Thr Asp Val Leu Ser Phe 
             340                345                350
Val Leu Lys Glu Asn Glu Thr Gly Asp Val Glu Trp Asp Ala Phe Ser 
         355                360                365
Ile Pro Glu Leu Gln Asn Phe Leu Thr Ile Leu Glu Lys Glu Glu Gln 
     370                375                380
Asp Lys Ile His Gln Leu Gln Lys Lys Tyr Asn Lys Phe Arg Gln Lys 
 385                390                395                400
Leu Glu Glu Ala Leu Arg Glu Ser Gln Gly Lys Pro Gly 
                 405                410



<210> 387
<211> 3278
<212> DNA
<213> Homo sapiens
<308> AK056568
<400> 387

ccatctatg  tgccatcaa  gaggtgaac  tggcggcta  cacggacaa  cggacatcc  60
tctacctgc  cctagatgc  atcaagcag  tgcacatca  cagcaccac  accgtcagt  120
aggtcatcc  ggggctgct  aagaagttc  tggttgtgg  caatcccca  aagtttgca  180
tttttaagc  gatacacaa  gacggacaa  gtaggagaa  gagtgaacc  aaccagacc  240
ttcccttcc  acctgtgtc  aagcccacc  actaaaact  ctgccggcc  tgggtggga  300
ctgtgggct  ctcctgagc  ccaggggtc  agctgccca  gtggtgttc  gatctgtgg  360
atccgggca  ggaggcaag  gcagagtcc  tgactctgc  tgtgacttc  ggaaaacca  420
accctaggc  cccatttcc  gatctgtgc  atgggagga  tctgcccca  cattcctaa  480
ctttcagga  atgatgtga  tggaatcat  ctttaaact  tgagcagac  cccaagata  540
aaggttatt  ccctgttca  tactgtcat  ttcatttca  taaaaggcc  gtgtctact  600
ccagttgta  gtaccccac  tctgcattt  caatccttt  ccgcaagcc  gggccccgc  660
cttcttttc  gggaagagc  cccagcacc  tctcttggt  tgcagtgct  ttccagaaa  720
tctccattg  tgaccgccc  ctctacctg  gcctgcttg  tgggcctga  acggaggtc  780
tcagctttg  gctaaagga  aatgaaact  gagaggtag  gtgggatgc  ttctccatc  840
ctgaacttc  gaacttcct  acaatcctg  aaaaagagg  gcaggacaa  atccaacaa  900
tgcaaaaga  gtatgacaa  tttaggcag  aactggagg  ggccttaag  gaatcccag  960
gcaaacctg  gtaaccggt  ctgcttcct  tcctcctgg  gcattcaga  ttatttgta  1020
tattaatta  tattttgca  cagacactt  ttctcagga  atctctggc  ggtgcattt  1080
tgcctgccc  gcagttcca  ctgtggcaa  agtctcttc  atggacaag  gtttgcacg  1140
gggttcagc  gtgcccgcc  ccaggctgt  ccccaccac  gattctgcc  aggatcaga  1200
ctcatgtga  acaaacagc  gacgtcctc  ctcgatctg  aagcctttc  ccaaccaaa  1260
agttgcctc  ctcgtcacc  aactggaac  tcacaccag  cggcaaagg  aggaagaaa  1320
gttttagag  tgtgtgttc  ttctctggc  ttgattctt  tttgagttc  cttacttgc  1380
acgtacagg  ccattattt  tgagtgaaa  gttgtagca  attcctttt  caggtctga  1440
ctaagcccc  gaaagcagg  taatgctca  aaaaggact  ttcccgcgg  cccaaggtg  1500
ctgttgttc  cacttaagg  aagtttata  agctactgg  cccagatgc  cagggtaag  1560
agcaccaaa  ctgaggctg  ctcagagat  tccagagaa  ctgcagcct  ccctggccc  1620
ggctctggc  ctggcccac  ttgcacatg  aaacccaaa  gcatatatc  gcgtatgtg  1680
ggtacttag  cacatcttt  tcaacaacc  gttcgtttt  aagttacaa  tttgaattt  1740
atgttgtca  catcgtcat  tgtttcccc  aagggaagc  agtcattga  catttaaaa  1800
gtctcctgc  aagtatgga  atcagacag  aagagaaag  caaaaagca  tgcagagaa  1860
ggtgtccaa  ctgtcttca  ccttcccca  ctaaagagc  gaggagggc  tgggctact  1920
gggttcccc  tcggcctcc  gcactgcct  cctcctccc  ctgcgactc  gggatctcc  1980
ggtgctgcc  aaggagttg  cttgattac  gagagggga  cctccaatt  ggccaactt  2040
gagtccttt  tgttttgaa  catgggcca  acccggcac  gcgctcgga  agccggtgg  2100
cctggcctc  ccgtcgacc  cagtgcctt  ttgttttca  agagaaata  gagtagggc  2160
agtttgcct  aagctctgc  gctggcttc  cctgccagg  agtgaacaa  ggcggcggt  2220
tgggagaca  ggccaggag  gcccgcgtt  agtatgggt  gagggtcac  gacctccct  2280
ccatctggg  gcctgagtt  tgactccaa  cagtgatac  agaccacat  gacagggag  2340
atcaaattc  tgacttaca  ttgcactgg  ttcttgttt  ggctgaatc  taaaataaa  2400
tagtcaaaa  attccaaca  gtagccagg  ctgcagaga  actccagtg  agagggaga  2460
ggacttgta  ttttcaaag  agggctggt  ttccaaccc  gcctctgag  aaccatttc  2520
ttgctatcc  ctgccttcc  aagtccctc  tgggtcggt  caagcccaa  cttgttcgt  2580
tagcttcag  agttccctc  ccgacccag  ctgagtcca  actgcccct  atcccagaa  2640
gaatgctga  ccctcgtcg  atgaactgt  catagtctc  agagcttca  aggcaacac  2700
agctcgcaa  tctaagatt  ttttaaacc  caaaaaccc  ggttagcca  ctcatgctc  2760
gccttatca  ttccctccc  ttagaaact  tctccctgc  gtatattaa  gggagcagg  2820
ggagagtca  tttccttcg  cctgcatgt  tctaacatt  atagaaggc  tggctcctg  2880
tgcaaccgc  gtgaatgct  ctgagaacc  ccctctatg  ggatggcta  tttattttt  2940
agaaggaaa  aaaagtcat  tatatatac  cataaaggc  tatagctat  tataaagag  3000
taagggtgt  tatgaaatg  gaaaattat  ggacaattc  gactttact  aagcacagt  3060
agacccaag  cctatgctg  ggtctaaac  tctgaaaaa  gtatagtat  gagtacccg  3120
tccctccca  aggtgggag  aactgctgg  agtgccttc  ttggttgtg  tgctcagtg  3180
gtaagtgtt  gtttccagg  tattttctt  ttaaatgtc  ttcttatat  ggttttaaa  3240
aaaagtaat  aaagcctgt  gcaaaaatg  ctcatgtt  3278



<210> 388
<211> 390
<212> PRT
<213> Homo sapiens
<308> NP_113625
<400> 388

Met Ala Ser Pro Ala Ile Gly Gln Arg Pro Tyr Pro Leu Leu Leu Asp 
  1               5                  10                  15
Pro Glu Pro Pro Arg Tyr Leu Gln Ser Leu Ser Gly Pro Glu Leu Pro 
             20                  25                  30
Pro Pro Pro Pro Asp Arg Ser Ser Arg Leu Cys Val Pro Ala Pro Leu 
         35                  40                  45
Ser Thr Ala Pro Gly Ala Arg Glu Gly Arg Ser Ala Arg Arg Ala Ala 
     50                  55                  60
Arg Gly Asn Leu Glu Pro Pro Pro Arg Ala Ser Arg Pro Ala Arg Pro 
 65                  70                  75                  80
Leu Arg Pro Gly Leu Gln Gln Arg Leu Arg Arg Arg Pro Gly Ala Pro 
                 85                  90                  95
Arg Pro Arg Asp Val Arg Ser Ile Phe Glu Gln Pro Gln Asp Pro Arg 
             100                105                110
Val Pro Ala Glu Arg Gly Glu Gly His Cys Phe Ala Glu Leu Val Leu 
         115                120                125
Pro Gly Gly Pro Gly Trp Cys Asp Leu Cys Gly Arg Glu Val Leu Arg 
     130                135                140
Gln Ala Leu Arg Cys Thr Asn Cys Lys Phe Thr Cys His Pro Glu Cys 
 145                150                155                160
Arg Ser Leu Ile Gln Leu Asp Cys Ser Gln Gln Glu Gly Leu Ser Arg 
                 165                170                175
Asp Arg Pro Ser Pro Glu Ser Thr Leu Thr Val Thr Phe Ser Gln Asn 
             180                185                190
Val Cys Lys Pro Val Glu Glu Thr Gln Arg Pro Pro Thr Leu Gln Glu 
         195                200                205
Ile Lys Gln Lys Ile Asp Ser Tyr Asn Thr Arg Glu Lys Asn Cys Leu 
     210                215                220
Gly Met Lys Leu Ser Glu Asp Gly Thr Tyr Thr Gly Phe Ile Lys Val 
 225                230                235                240
His Leu Lys Leu Arg Arg Pro Val Thr Val Pro Ala Gly Ile Arg Pro 
                 245                250                255
Gln Ser Ile Tyr Asp Ala Ile Lys Glu Val Asn Leu Ala Ala Thr Thr 
             260                265                270
Asp Lys Arg Thr Ser Phe Tyr Leu Pro Leu Asp Ala Ile Lys Gln Leu 
         275                280                285
His Ile Ser Ser Thr Thr Thr Val Ser Glu Val Ile Gln Gly Leu Leu 
     290                295                300
Lys Lys Phe Met Val Val Asp Asn Pro Gln Lys Phe Ala Leu Phe Lys 
 305                310                315                320
Arg Ile His Lys Asp Gly Gln Val Leu Phe Gln Lys Leu Ser Ile Ala 
                 325                330                335
Asp Arg Pro Leu Tyr Leu Arg Leu Leu Ala Gly Pro Asp Thr Glu Val 
             340                345                350
Leu Ser Phe Val Leu Lys Glu Asn Glu Thr Gly Glu Val Glu Trp Asp 
         355                360                365
Ala Phe Ser Ile Pro Glu Leu Gln Asn Phe Leu Ser Ser Trp Cys Ile 
     370                375                380
Gln Ile Tyr Leu Tyr Tyr 
 385                390



<210> 389
<211> 1586
<212> DNA
<213> Rattus norvegicus
<308> AF002281
<400> 389

gatcccccg  gctgcaggg  actaagtgg  ttgtccggg  tccgagact  gcgctctgc  60
gagacacca  atcgctgga  cctctcaca  gaaggcgtc  tgccccaaa  cgtagttct  120
ccgggccct  cgtcctggg  gttcagact  tcaggaggc  tagacttca  ccagccttt  180
gtcatcacc  ggatcactc  gggaagcaa  gcagaagcc  ccaacctgt  ccctggcga  240
atgatactg  ctatcgatg  ctttggtac  gagtccatg  ctcatgctg  tgctcagga  300
aggatcaaa  cagcatctt  ccagttgtg  ctcaagatt  acagggcag  aactcgctt  360
tgtcccgca  tgtcggaag  tgggaaagc  catcccttt  aaatcaacc  agaggctga  420
ccgcaggat  tgaactact  tgaacacaa  cacaatatt  ggcccaaac  tttcataat  480
ccaggccga  ccagtggct  cagcactcc  tccggtatt  actgtggca  tggacgtag  540
accccttct  ccgtcagta  cgttagtac  atctgccca  gtgacttga  agttgctgc  600
aagatggcc  ctaacattc  tttggaaat  gaacttccg  gcgtgaaga  tgtacatgc  660
cagtttaac  ctcctatgc  gttgtactc  gatgacaat  ttatggaaa  acttcaggg  720
caggtttcc  cagctctag  ggagacacc  tccatgagt  aacccacag  ttcagttcc  780
cctcagtcg  acgtgtacc  aatgctgca  gacaatcgg  atgaaccag  tgctcctcg  840
cagtcaggc  ccttcaggg  cctgcagga  ctggtgaac  acgggtctg  tgaccgtcc  900
gctggaact  gaagtgtga  gccggttac  aaagtccat  gcggggctg  cggtgccca  960
aggatgcca  tctgtgaca  gtgtggcag  ggtattgta  gtgctgtgg  caaggcccg  1020
gataagtac  ggcaccccg  gtgctttgt  tgtgctgac  gtaacctca  cctcaagca  1080
aaaggttac  tcttcgtgg  gggggagct  tattgtgag  tgcacgcaa  agcccgggc  1140
aggccccca  aaggctacg  caccgtcac  ctgtacccc  aagcttaaa  tctttacag  1200
cgagaacac  cattcacgc  tgcgcacac  cgaacaccg  cggatgata  ggaggactt  1260
aagcaggag  agtgcgaag  tcacctccc  atcgaaagc  aggctttta  tcatttatc  1320
tactgtgta  tgagggaaa  acatgggga  cagaggcct  cctactgac  aaagtatta  1380
ctgtgggtt  taattcttt  tctttgggg  cagcaatgg  gacatttaa  gcaataacg  1440
tgtaatacc  tgctctacg  tttccatct  ttacacgcc  atccgatgc  tgaacacct  1500
gatatgtag  gggggtcca  ttgtctttc  ttccaagtt  cttttggta  ttgtagtaa  1560
gccaaatta  agctttgta  tggaac  1586



<210> 390
<211> 362
<212> PRT
<213> Rattus norvegicus
<308> AAC16671
<400> 390

Met Pro Gln Asn Val Val Leu Pro Gly Pro Ala Ser Trp Gly Phe Arg 
  1               5                  10                  15
Leu Ser Gly Gly Ile Asp Phe Asn Gln Pro Leu Val Ile Thr Arg Ile 
             20                  25                  30
Thr Pro Gly Ser Lys Ala Glu Ala Ala Asn Leu Cys Pro Gly Asp Met 
         35                  40                  45
Ile Leu Ala Ile Asp Gly Phe Gly Thr Glu Ser Met Thr His Ala Asp 
     50                  55                  60
Ala Gln Asp Arg Ile Lys Ala Ala Ser Tyr Gln Leu Cys Leu Lys Ile 
 65                  70                  75                  80
Asp Arg Ala Glu Thr Arg Leu Cys Pro Ala Val Ser Glu Asp Gly Lys 
                 85                  90                  95
Ala His Pro Phe Lys Ile Asn Leu Glu Ala Glu Pro Gln Asp Val Asn 
             100                105                110
Tyr Phe Glu His Lys His Asn Ile Arg Pro Lys Pro Phe Ile Ile Pro 
         115                120                125
Gly Arg Thr Ser Gly Cys Ser Thr Pro Ser Gly Ile Asp Cys Gly Ser 
     130                135                140
Gly Arg Ser Thr Pro Ser Ser Val Ser Thr Val Ser Thr Ile Cys Pro 
 145                150                155                160
Gly Asp Leu Lys Val Ala Ala Lys Met Ala Pro Asn Ile Pro Leu Glu 
                 165                170                175
Met Glu Leu Pro Gly Val Lys Ile Val His Ala Gln Phe Asn Thr Pro 
             180                185                190
Met Gln Leu Tyr Ser Asp Asp Asn Ile Met Glu Thr Leu Gln Gly Gln 
         195                200                205
Val Ser Thr Ala Leu Gly Glu Thr Pro Ser Met Ser Glu Pro Thr Ala 
     210                215                220
Ser Val Pro Pro Gln Ser Asp Val Tyr Arg Met Leu His Asp Asn Arg 
 225                230                235                240
Asp Glu Pro Ala Ala Pro Arg Gln Ser Gly Ser Phe Arg Val Leu Gln 
                 245                250                255
Glu Leu Val Asn Asp Gly Ser Asp Asp Arg Pro Ala Gly Thr Arg Ser 
             260                265                270
Val Arg Pro Val Thr Lys Val His Gly Gly Ala Gly Gly Ala Gln Arg 
         275                280                285
Met Pro Leu Cys Asp Lys Cys Gly Ser Gly Ile Val Gly Ala Val Val 
     290                295                300
Lys Ala Arg Asp Lys Tyr Arg His Pro Glu Cys Phe Val Cys Ala Asp 
 305                310                315                320
Cys Asn Leu Asn Leu Lys Gln Lys Gly Tyr Phe Phe Val Glu Gly Glu 
                 325                330                335
Leu Tyr Cys Glu Met His Ala Arg Ala Arg Ala Arg Pro Pro Glu Gly 
             340                345                350
Tyr Asp Thr Val Thr Leu Tyr Pro Lys Ala 
         355                360



<210> 391
<211> 1722
<212> DNA
<213> Homo sapiens
<308> AF039018
<400> 391

gcggccggt  gaccggagt  gctgccctg  gcggggaca  tcagagccc  gtgggcggg  60
ggaaggcgg  atgccccag  cggtgatcc  cccgggccc  gcgccctgg  gcttcaggc  120
ctcaggggg  atagacttc  accagcctt  ggtcatcac  aggattaca  caggaagca  180
ggcggcagc  gccaacctg  gtcctggag  tgtcatcct  gctattgac  gctttggga  240
agagtccat  actcatgct  atgcgcagg  caggattaa  gcagcagct  accagctgt  300
tctcaaaat  gacagggga  aaactcact  atggtctcc  caagtatct  aagatggga  360
agcccatcc  ttcaaaatc  acttagaat  agaaccaca  gacgggaac  actttgaac  420
caagcataa  attcggccc  aacctttcg  gatcccggg  cgaagcagt  gatgcagca  480
tccctccgg  attgactgt  gcagtggac  cagcacccc  tcttctgtc  gtactgtta  540
taccatttg  ccaggtgac  tgaaagttg  ggctaagct  gcccctaac  ttcctttgg  600
aatggaact  cctggtgtg  agattgtac  tgctcagtt  aatacacct  tgcagttgt  660
ctcagatga  aatattatg  aaacactcc  gggtcaggt  tcaacagcc  taggggaaa  720
acctttgat  aacgagccc  cagcctcgg  gccccccga  tcggacgtg  accggatgc  780
ccacgacaa  cggaatgag  ccacacagc  tcgccagtc  ggctccttc  gagtgctcc  840
gggaatggt  gacgatggc  ctgatgacc  tccggctgg  acgcggagt  tgagagctc  900
ggtgacgaa  gtccatggc  gttcaggcg  ggcacagag  atgccgctc  gtgacaaat  960
tgggagtgg  atagttggt  ctgtggtga  ggcgcggga  aagtaccgg  accctgagt  1020
cttcgtgtg  gccgactgc  acctcaacc  caagcaaaa  ggctacttc  tcatagaag  1080
ggagctgta  tgcgaaacc  acgcaagag  ccgcacaaa  cccccagag  gctatgaca  1140
ggtcactct  tatcccaaa  cttaagtct  tgcaggcgt  gcacgcacg  acgcaccca  1200
ccacgcgca  ttacacgag  agacattca  ggctttggg  agaaggatt  tgcagattg  1260
caactccaa  tctaaagtc  aggctttag  cctttatcc  attgtttat  gaggaaaag  1320
aatgggagg  aaatgcctg  tatgtgaaa  aaacataca  ttagctatg  tttgcaact  1380
tttttgggg  tagcaataa  gatatttaa  gcaataatt  tttgtatgt  atactccac  1440
atttacatg  atattacag  catcaaaca  ataaacatc  agatatttg  aggactcta  1500
ttgtctttc  ttgacaagt  gattttgca  ttgtggtaa  tagcaaata  caatcttgt  1560
ttctaacat  atctgcagt  gtctgtatg  gttttaact  ttacagtgc  tgttaggga  1620
aaattccct  aatttcttt  gttttgtat  caaacaatt  tgccactcg  tgcaacaaa  1680
ataataaat  cataaagga  ttaaaaaaa  aaaaaaaaa  aa  1722



<210> 392
<211> 365
<212> PRT
<213> Homo sapiens
<308> AF039018
<400> 392

Met Pro Gln Thr Val Ile Leu Pro Gly Pro Ala Pro Trp Gly Phe Arg 
  1               5                  10                  15
Leu Ser Gly Gly Ile Asp Phe Asn Gln Pro Leu Val Ile Thr Arg Ile 
             20                  25                  30
Thr Pro Gly Ser Lys Ala Ala Ala Ala Asn Leu Cys Pro Gly Asp Val 
         35                  40                  45
Ile Leu Ala Ile Asp Gly Phe Gly Thr Glu Ser Met Thr His Ala Asp 
     50                  55                  60
Ala Gln Asp Arg Ile Lys Ala Ala Ala His Gln Leu Cys Leu Lys Ile 
 65                  70                  75                  80
Asp Arg Gly Glu Thr His Leu Trp Ser Pro Gln Val Ser Glu Asp Gly 
                 85                  90                  95
Lys Ala His Pro Phe Lys Ile Asn Leu Glu Ser Glu Pro Gln Asp Gly 
             100                105                110
Asn Tyr Phe Glu His Lys His Asn Ile Arg Pro Lys Pro Phe Val Ile 
         115                120                125
Pro Gly Arg Ser Ser Gly Cys Ser Thr Pro Ser Gly Ile Asp Cys Gly 
     130                135                140
Ser Gly Arg Ser Thr Pro Ser Ser Val Ser Thr Val Ser Thr Ile Cys 
 145                150                155                160
Pro Gly Asp Leu Lys Val Ala Ala Lys Leu Ala Pro Asn Ile Pro Leu 
                 165                170                175
Glu Met Glu Leu Pro Gly Val Lys Ile Val His Ala Gln Phe Asn Thr 
             180                185                190
Pro Met Gln Leu Tyr Ser Asp Asp Asn Ile Met Glu Thr Leu Gln Gly 
         195                200                205
Gln Val Ser Thr Ala Leu Gly Glu Thr Pro Leu Met Asn Glu Pro Thr 
     210                215                220
Ala Ser Val Pro Pro Glu Ser Asp Val Tyr Arg Met Leu His Asp Asn 
 225                230                235                240
Arg Asn Glu Pro Thr Gln Pro Arg Gln Ser Gly Ser Phe Arg Val Leu 
                 245                250                255
Gln Gly Met Val Asp Asp Gly Ser Asp Asp Arg Pro Ala Gly Thr Arg 
             260                265                270
Ser Val Arg Ala Pro Val Thr Lys Val His Gly Gly Ser Gly Gly Ala 
         275                280                285
Gln Arg Met Pro Leu Cys Asp Lys Cys Gly Ser Gly Ile Val Gly Ala 
     290                295                300
Val Val Lys Ala Arg Asp Lys Tyr Arg His Pro Glu Cys Phe Val Cys 
 305                310                315                320
Ala Asp Cys Asn Leu Asn Leu Lys Gln Lys Gly Tyr Phe Phe Ile Glu 
                 325                330                335
Gly Glu Leu Tyr Cys Glu Thr His Ala Arg Ala Arg Thr Lys Pro Pro 
             340                345                350
Glu Gly Tyr Asp Thr Val Thr Leu Tyr Pro Lys Ala Ter 
         355                360                365



<210> 393
<211> 2002
<212> DNA
<213> Rattus norvegicus
<308> AF003825
<400> 393

gaattcggc  cgaggaaag  cacgcaagc  caggcacac  ggctctgga  ttccattag  60
aaaaagtga  ccgagcaag  gttagcggg  gaagatttt  ttttttttg  atctttttc  120
tcgtcttgg  gccaaagaa  cgactctgg  ctcccgtcc  agaagctcc  actggattg  180
tcctattcc  tcggtggat  tctttccta  tcgcattta  tctgaaccc  tccctcgct  240
cttccttcc  gcccttcac  ttcagatcg  ctcgcccca  ctctccagt  ccctcctgg  300
aagtgcagg  gaattggac  cacggggac  cacgccttc  cggacgcgc  agcaaaggg  360
tgggctgac  tcaggacca  gctgttggc  tagaaggca  ccagacaca  agctacgtg  420
gtgttgatt  cagtggcaa  gggggacgt  gagaggcag  ccaccggcc  ggcctccta  480
ccctccccc  ccaaccagc  gtgagaatc  caggactcg  gatcttcaa  cggcggccg  540
ccggcggga  ctccgcatt  gatttgggg  tcgttattg  tcggctgtt  ttattatcg  600
tattttatt  ttatttttt  aacctaagg  agaaagaca  atacacaca  aactgtggg  660
tttatttaa  atgatcttg  caaacgcct  ctgcctctt  ttcttttta  acgaaaccc  720
ccgctcttt  gccagccct  cctccctgc  gggctctga  ctccacggc  ggcgccccc  780
agtggactg  gtccgggcc  atgagctgt  tgcggctga  tccaactgc  gctccaggt  840
ccgcaccct  cggcagtgc  tggcaggcc  ggatcgcaa  accatgctg  ccaataagg  900
gtgccaggc  gccctggag  tcttgcagg  aagcccact  tatgactgc  gctgcaagc  960
gggcatgaa  aaggagctg  agtgtctgc  gatctactg  agcatccat  tggggctga  1020
agagggtga  gagttctat  aagcttccc  ctatgagcc  gtgacctcg  gcctctcgg  1080
catcttcag  ctcgcttca  tcttctcag  gacagggac  gacccggcg  tcagtacca  1140
aagcaacca  tgcctggat  ccgccaagg  ctgcaacct  aatgacaac  gcaagaagc  1200
tcgctcctc  tatatctcc  tctgcaacc  tgagatctc  cccaccgaa  gctgcaacc  1260
ccgcaagtg  cacaaggct  tgcgccagt  ctttgaccg  gtgcccagc  agtatacct  1320
ccgcatgct  ttctgctcc  gtcaggacc  ggcatgtgc  gagcgtcgc  ggcaaacca  1380
cctgcccag  tgctcctat  aggacaagg  gaagcccaa  tgcctggac  tgcgcagcc  1440
gtgtcgtac  gaccacctg  gccggtccc  actggcaga  ttccacgcc  actgtcgag  1500
ctcctaccg  acaatcacc  gctgtcctg  ggacaacta  caggcatgt  tgggctcct  1560
tgctggcat  attgggttt  atatgacac  caactatgt  gactccaac  ccacgggca  1620
cgtggtgtc  ccctggtgc  attgtcgtg  cagtgggaa  atggaagaa  agtgtgaga  1680
gttcctcag  gacttcacg  aaaacccat  cctccggaa  gccattcag  cctttggta  1740
tggcacaga  gtgaacatg  ctcccaaag  cccctcact  ccagctacc  aggcccctc  1800
ggtggagaa  actccttca  tgccagatg  cctcagtga  agcaccagc  tggggacca  1860
tgtcatcac  acctgcaca  ctatccagg  gcaagggct  aaggccaac  actccaaag  1920
gttaagcat  tgcttcaca  agctcacga  aaacatcag  ccagggagt  aaaaggtga  1980
caaacttaa  tcaggctcc  gc  2002



<210> 394
<211> 464
<212> PRT
<213> Rattus norvegicus
<308> AAD09310
<400> 394

Met Ile Leu Ala Asn Ala Phe Cys Leu Phe Phe Phe Leu Asp Glu Thr 
  1               5                  10                  15
Leu Arg Ser Leu Ala Ser Pro Ser Ser Leu Gln Gly Ser Glu Leu His 
             20                  25                  30
Gly Trp Arg Pro Gln Val Asp Cys Val Arg Ala Asn Glu Leu Cys Ala 
         35                  40                  45
Ala Glu Ser Asn Cys Ser Ser Arg Tyr Arg Thr Leu Arg Gln Cys Leu 
     50                  55                  60
Ala Gly Arg Asp Arg Asn Thr Met Leu Ala Asn Lys Glu Cys Gln Ala 
 65                  70                  75                  80
Ala Leu Glu Val Leu Gln Glu Ser Pro Leu Tyr Asp Cys Arg Cys Lys 
                 85                  90                  95
Arg Gly Met Lys Lys Glu Leu Gln Cys Leu Gln Ile Tyr Trp Ser Ile 
             100                105                110
His Leu Gly Leu Thr Glu Gly Glu Glu Phe Tyr Glu Ala Ser Pro Tyr 
         115                120                125
Glu Pro Val Thr Ser Arg Leu Ser Asp Ile Phe Arg Leu Ala Ser Ile 
     130                135                140
Phe Ser Gly Thr Gly Thr Asp Pro Ala Val Ser Thr Lys Ser Asn His 
 145                150                155                160
Cys Leu Asp Ala Ala Lys Ala Cys Asn Leu Asn Asp Asn Cys Lys Lys 
                 165                170                175
Leu Arg Ser Ser Tyr Ile Ser Ile Cys Asn Arg Glu Ile Ser Pro Thr 
             180                185                190
Glu Arg Cys Asn Arg Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe 
         195                200                205
Asp Arg Val Pro Ser Glu Tyr Thr Tyr Arg Met Leu Phe Cys Ser Cys 
     210                215                220
Gln Asp Gln Ala Cys Ala Glu Arg Arg Arg Gln Thr Ile Leu Pro Ser 
 225                230                235                240
Cys Ser Tyr Glu Asp Lys Glu Lys Pro Asn Cys Leu Asp Leu Arg Ser 
                 245                250                255
Leu Cys Arg Thr Asp His Leu Cys Arg Ser Arg Leu Ala Asp Phe His 
             260                265                270
Ala Asn Cys Arg Ala Ser Tyr Arg Thr Ile Thr Ser Cys Pro Ala Asp 
         275                280                285
Asn Tyr Gln Ala Cys Leu Gly Ser Tyr Ala Gly Met Ile Gly Phe Asp 
     290                295                300
Met Thr Pro Asn Tyr Val Asp Ser Asn Pro Thr Gly Ile Val Val Ser 
 305                310                315                320
Pro Trp Cys Asn Cys Arg Gly Ser Gly Asn Met Glu Glu Glu Cys Glu 
                 325                330                335
Lys Phe Leu Arg Asp Phe Thr Glu Asn Pro Cys Leu Arg Asn Ala Ile 
             340                345                350
Gln Ala Phe Gly Asn Gly Thr Asp Val Asn Met Ser Pro Lys Gly Pro 
         355                360                365
Ser Leu Pro Ala Thr Gln Ala Pro Arg Val Glu Lys Thr Pro Ser Leu 
     370                375                380
Pro Asp Asp Leu Ser Asp Ser Thr Ser Leu Gly Thr Ser Val Ile Thr 
 385                390                395                400
Thr Cys Thr Ser Ile Gln Glu Gln Gly Leu Lys Ala Asn Asn Ser Lys 
                 405                410                415
Glu Leu Ser Met Cys Phe Thr Glu Leu Thr Thr Asn Ile Ser Pro Gly 
             420                425                430
Ser Lys Lys Val Ile Lys Leu Asn Ser Gly Ser Ser Arg Ala Arg Leu 
         435                440                445
Ser Ala Ala Leu Thr Ala Leu Pro Leu Leu Met Leu Thr Leu Ala Leu 
     450                455                460



<210> 395
<211> 1395
<212> DNA
<213> Homo sapiens
<308> U93703
<400> 395

atgatcttg  caaacgcct  ctgcctctt  ttctttcta  acgagaccc  ccgctcttt  60
gccagccct  cctccctgc  gggccccga  ctccacggc  ggcgccccc  agtggactg  120
gtccgggcc  atgagctgt  tgccgccga  tccaactgc  gctctcgct  ccgcactct  180
cggcagtgc  tggcaggcc  cgaccgcaa  accatgctg  ccaacaagg  gtgccaggc  240
gccttggag  tcttgcagg  gagcccgct  tacgactgc  gctgcaagc  gggcatgaa  300
aaggagctg  agtgtctgc  gatctactg  agcatccac  tggggctga  cgagggtga  360
gagttctac  aagcctccc  ctatgagcc  gtgacctcc  gcctctcgg  catcttcag  420
cttgcttca  tcttctcag  gacaggggc  gacccggtg  tcagcgcca  gagcaacca  480
tgcctggat  ctgccaagg  ctgcaacct  aatgacaac  gcaagaagc  gcgctcctc  540
tacatctcc  tctgcaacc  cgagatctc  cccaccgag  gctgcaacc  ccgcaagtg  600
cacaaggcc  tgcgccagt  cttcgaccg  gtgcccagc  agtacacct  ccgcatgct  660
ttctgctcc  gccaagacc  ggcgtgcgc  gagcgccgc  ggcaaacca  cctgcccag  720
tgctcctat  aggacaagg  gaagcccaa  tgcctggac  tgcgtggcg  gtgccggac  780
gaccacctg  gtcggtccc  gctggccga  ttccatgcc  attgtcgag  ctcctacca  840
acggtcacc  gctgccctg  ggacaatta  caggcgtgt  tgggctctt  tgctggcat  900
attgggttt  acatgacac  taactatgt  gactccagc  ccactggca  cgtggtgtc  960
ccctggtgc  gctgtcgtg  cagcgggaa  atggaggag  agtgtgaga  gttcctcag  1020
gacttcacc  agaacccat  cctccggaa  gccatccag  cctttggca  cggcacgga  1080
gtgaacgtg  ccccaaaag  cccctcgtt  caggccacc  aggcccctc  ggtggagaa  1140
acgccttct  tgccagatg  cctcagtga  agtaccagc  tggggacca  tgtcatcac  1200
acctgcacg  ctgtccagg  gcaggggct  aaggccaac  actccaaag  gttaagcat  1260
tgcttcaca  agctcacga  aaatatcat  ccagggagt  acaaggtga  caaacctaa  1320
tcaggcccc  gcagagcca  accgtcggc  gccttgacc  tgctgtctg  cctgatgct  1380
aaacaggcc  tgtag  1395



<210> 396
<211> 464
<212> PRT
<213> Homo sapiens
<308> O00451
<400> 396

Met Ile Leu Ala Asn Val Phe Cys Leu Phe Phe Phe Leu Asp Glu Thr 
  1               5                  10                  15
Leu Arg Ser Leu Ala Ser Pro Ser Ser Leu Gln Gly Pro Glu Leu His 
             20                  25                  30
Gly Trp Arg Pro Pro Val Asp Cys Val Arg Ala Asn Glu Leu Cys Ala 
         35                  40                  45
Ala Glu Ser Asn Cys Ser Ser Arg Tyr Arg Thr Leu Arg Gln Cys Leu 
     50                  55                  60
Ala Gly Arg Asp Arg Asn Thr Met Leu Ala Asn Lys Glu Cys Gln Ala 
 65                  70                  75                  80
Ala Leu Glu Val Leu Gln Glu Ser Pro Leu Tyr Asp Cys Arg Cys Lys 
                 85                  90                  95
Arg Gly Met Lys Lys Glu Leu Gln Cys Leu Gln Ile Tyr Trp Ser Ile 
             100                105                110
His Leu Gly Leu Thr Glu Gly Glu Glu Phe Tyr Glu Ala Ser Pro Tyr 
         115                120                125
Glu Pro Val Thr Ser Arg Leu Ser Asp Ile Phe Arg Leu Ala Ser Ile 
     130                135                140
Phe Ser Gly Thr Gly Ala Asp Pro Val Val Ser Ala Lys Ser Asn His 
 145                150                155                160
Cys Leu Asp Ala Ala Lys Ala Cys Asn Leu Asn Asp Asn Cys Lys Lys 
                 165                170                175
Leu Arg Ser Ser Tyr Ile Ser Ile Cys Asn Arg Glu Ile Ser Pro Thr 
             180                185                190
Glu Arg Cys Asn Arg Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe 
         195                200                205
Asp Arg Val Pro Ser Glu Tyr Thr Tyr Arg Met Leu Phe Cys Ser Cys 
     210                215                220
Gln Asp Gln Ala Cys Ala Glu Arg Arg Arg Gln Thr Ile Leu Pro Ser 
 225                230                235                240
Cys Ser Tyr Glu Asp Lys Glu Lys Pro Asn Cys Leu Asp Leu Arg Gly 
                 245                250                255
Val Cys Arg Thr Asp His Leu Cys Arg Ser Arg Leu Ala Asp Phe His 
             260                265                270
Ala Asn Cys Arg Ala Ser Tyr Gln Thr Val Thr Ser Cys Pro Ala Asp 
         275                280                285
Asn Tyr Gln Ala Cys Leu Gly Ser Tyr Ala Gly Met Ile Gly Phe Asp 
     290                295                300
Met Thr Pro Asn Tyr Val Asp Ser Ser Pro Thr Gly Ile Val Val Ser 
 305                310                315                320
Pro Trp Cys Ser Cys Arg Gly Ser Gly Asn Met Glu Glu Glu Cys Glu 
                 325                330                335
Lys Phe Leu Arg Asp Phe Thr Glu Asn Pro Cys Leu Arg Asn Ala Ile 
             340                345                350
Gln Ala Phe Gly Asn Gly Thr Asp Val Asn Val Ser Pro Lys Gly Pro 
         355                360                365
Ser Phe Gln Ala Thr Gln Ala Pro Arg Val Glu Lys Thr Pro Ser Leu 
     370                375                380
Pro Asp Asp Leu Ser Asp Ser Thr Ser Leu Gly Thr Ser Val Ile Thr 
 385                390                395                400
Thr Cys Thr Ser Val Gln Glu Gln Gly Leu Lys Ala Asn Asn Ser Lys 
                 405                410                415
Glu Leu Ser Met Cys Phe Thr Glu Leu Thr Thr Asn Ile Ile Pro Gly 
             420                425                430
Ser Asn Lys Val Ile Lys Pro Asn Ser Gly Pro Ser Arg Ala Arg Pro 
         435                440                445
Ser Ala Ala Leu Thr Val Leu Ser Val Leu Met Leu Lys Gln Ala Leu 
     450                455                460



<210> 397
<211> 1182
<212> DNA
<213> Rattus norvegicus
<308> AF003835
<400> 397

ggaagcttc  ccaccgcaa  gcagctaga  gtgcgggca  tctcagctg  ccactggga  60
tcgccaaca  catctcttg  gctccaggg  cgcaatcac  accggggat  tccagcaag  120
cttccggac  cacgcgtag  ggaggtggt  ccaccgcgc  caaacctgg  gcggtcgtg  180
cgtcaggac  acgctagat  ggcaattgg  tggaggcat  tggcgcgga  gggcactgg  240
aggagtgat  ggatcagct  ttaaggggc  gggtctgga  gcggagcat  ctgccgaga  300
cgttgaagt  cggcgctcc  cacagcttc  cgacactcc  gtctggaat  gctgtgttc  360
aggtcagat  agacattct  tcacaatgc  tgaaatcaa  gccagcaat  ttgatgaaa  420
acaggttca  cttctagca  agatgtgta  tcttattga  gaaaatgac  ataaaattg  480
ggctgacac  aagaaaaat  gtcacctga  tgaaaacat  gacaaagga  taatacatc  540
agctttcag  gtcttcttg  ttaatactg  aaacaagct  ctgttacag  agagatcgg  600
tgctaaaat  acctttcca  gttgtttca  caatagttg  tgtagtcat  cattaaata  660
ccccgggga  ctggaagaa  atgatgcca  gggtgtcaa  cgagcagca  agaagcgct  720
aaaggcgga  ctggggata  ccttggaag  ggttgatct  aatgaaatg  attatctaa  780
aagaattta  tacaaggcc  aatctgatg  tatctgggg  gaacatgaa  ttgattaca  840
tttgtttct  aggaagaat  taaccctga  tccggatcc  aacgagatt  aaagctatt  900
ctatgtatc  aaggaagaa  tcaaagaaa  tttgaagaa  gaagccagg  gcgaaatta  960
gtttactcc  tggtttaag  ttattgcag  cgcttttct  tttaaatgg  gggataact  1020
aaaccattt  agtcctttt  ttgaccatg  gaaaataca  agaatgtga  tgtgtaaat  1080
atttgagat  tttttctac  tactaagaa  ggtttgatt  tgttttaaa  tgggctccc  1140
tgtatgaca  atagatatt  tacaaccag  atttgtttt  ag  1182



<210> 398
<211> 227
<212> PRT
<213> Rattus norvegicus
<308> O35760
<400> 398

Met Pro Glu Ile Asn Ala Ser Asn Leu Asp Glu Lys Gln Val Gln Leu 
  1               5                  10                  15
Leu Ala Glu Met Cys Ile Leu Ile Asp Glu Asn Asp Asn Lys Ile Gly 
             20                  25                  30
Ala Asp Thr Lys Lys Asn Cys His Leu Asn Glu Asn Ile Asp Lys Gly 
         35                  40                  45
Leu Ile His Arg Ala Phe Ser Val Phe Leu Phe Asn Thr Glu Asn Lys 
     50                  55                  60
Leu Leu Leu Gln Gln Arg Ser Asp Ala Lys Ile Thr Phe Pro Gly Cys 
 65                  70                  75                  80
Phe Thr Asn Ser Cys Cys Ser His Pro Leu Asn Asn Pro Gly Glu Leu 
                 85                  90                  95
Glu Glu Asn Asp Ala Met Gly Val Lys Arg Ala Ala Gln Lys Arg Leu 
             100                105                110
Lys Ala Glu Leu Gly Ile Pro Leu Glu Glu Val Asp Leu Asn Glu Met 
         115                120                125
Asn Tyr Leu Thr Arg Ile Tyr Tyr Lys Ala Gln Ser Asp Gly Ile Trp 
     130                135                140
Gly Glu His Glu Ile Asp Tyr Ile Leu Phe Leu Arg Lys Asn Val Thr 
 145                150                155                160
Leu Asn Pro Asp Pro Asn Glu Ile Lys Ser Tyr Cys Tyr Val Ser Lys 
                 165                170                175
Glu Glu Leu Lys Glu Ile Leu Lys Lys Glu Ala Arg Gly Glu Ile Lys 
             180                185                190
Phe Thr Pro Trp Phe Lys Ile Ile Ala Asp Ala Phe Leu Phe Lys Trp 
         195                200                205
Trp Asp Asn Leu Asn His Leu Ser Pro Phe Val Asp His Glu Lys Ile 
     210                215                220
His Arg Met 
 225



<210> 399
<211> 918
<212> DNA
<213> Homo sapiens
<308> NM_018470
<400> 399

tggttgaac  gactcacca  gaaacgtga  tttcgtgtc  gacctctgc  gtatcagga  60
tcgattctt  gtgttaaac  agacaacgc  gaaggctcg  tgcagcagc  ctgcaaagg  120
gtggagccc  aacccacgc  gggcgtgtc  tcatggctt  tcctggcca  tctgatacc  180
agatgcagt  gccagaagt  cctgcactt  cactcctgt  aagtctctg  atggctatg  240
tgaggaaga  ctctgcact  ggcaaggaa  ttggccgtc  aagtgaagg  aatggtgat  300
ctggtggcc  ctttccggc  gtcaagttc  ctatcaagg  cattcagtt  tcggaaagt  360
gtgaaggca  acgcttcct  catggtgcc  gcctctctc  actctctag  aatattaag  420
ctaggctgc  gctgtatgt  agggctagt  ccctcttct  tgaatccag  ataactctg  480
agaagccga  taacaggca  gaagtgaag  gaaatcgct  taacaggaa  acagcaaag  540
agatgctaa  gaccacact  tttaacgaa  tggaaccaa  gagaaaata  ggtattact  600
aagactgca  ttccttgaa  agagtgctc  tctcagcaa  tcggaaatg  ctacacaaa  660
cgctttaca  gaaagactg  ttcaaagca  cacctttct  aatgttctc  ttcaggtga  720
aattcttct  ggtctcagc  ccaatttta  tgtcatttt  atcaataag  atacacatc  780
ctgccagga  ttgaacctg  tgcttgtcg  ggtggttag  gtttatttc  ggcatcatt  840
caaaatgtc  gatctgttc  agaacccta  tattaaagg  aaagagaaa  aaaaaaaaa  900
aaaaaaaaa  aaaaaaaa  918



<210> 400
<211> 228
<212> PRT
<213> Homo sapiens
<308> NP_004499
<400> 400

Met Met Pro Glu Ile Asn Thr Asn His Leu Asp Lys Gln Gln Val Gln 
  1               5                  10                  15
Leu Leu Ala Glu Met Cys Ile Leu Ile Asp Glu Asn Asp Asn Lys Ile 
             20                  25                  30
Gly Ala Glu Thr Lys Lys Asn Cys His Leu Asn Glu Asn Ile Glu Lys 
         35                  40                  45
Gly Leu Leu His Arg Ala Phe Ser Val Phe Leu Phe Asn Thr Glu Asn 
     50                  55                  60
Lys Leu Leu Leu Gln Gln Arg Ser Asp Ala Lys Ile Thr Phe Pro Gly 
 65                  70                  75                  80
Cys Phe Thr Asn Thr Cys Cys Ser His Pro Leu Ser Asn Pro Ala Glu 
                 85                  90                  95
Leu Glu Glu Ser Asp Ala Leu Gly Val Arg Arg Ala Ala Gln Arg Arg 
             100                105                110
Leu Lys Ala Glu Leu Gly Ile Pro Leu Glu Glu Val Pro Pro Glu Glu 
         115                120                125
Ile Asn Tyr Leu Thr Arg Ile His Tyr Lys Ala Gln Ser Asp Gly Ile 
     130                135                140
Trp Gly Glu His Glu Ile Asp Tyr Ile Leu Leu Val Arg Lys Asn Val 
 145                150                155                160
Thr Leu Asn Pro Asp Pro Asn Glu Ile Lys Ser Tyr Cys Tyr Val Ser 
                 165                170                175
Lys Glu Glu Leu Lys Glu Leu Leu Lys Lys Ala Ala Ser Gly Glu Ile 
             180                185                190
Lys Ile Thr Pro Trp Phe Lys Ile Ile Ala Ala Thr Phe Leu Phe Lys 
         195                200                205
Trp Trp Asp Asn Leu Asn His Leu Asn Gln Phe Val Asp His Glu Lys 
     210                215                220
Ile Tyr Arg Met 
 225



<210> 401
<211> 3449
<212> DNA
<213> Rattus norvegicus
<308> AF004017
<400> 401

gctttgatc  gttcagata  aggatgtcc  ctgaaaatg  ggaagggaa  cccaataat  60
ttggggaga  aggaagagc  cgaagctcc  ctttcctca  ggttttcca  ccaatgttt  120
accacagta  tttcacttc  gcagtctcc  cggccgcag  acgtatccg  ttcatcttg  180
gagaggaag  tgacagccc  gcacctcct  agctcttca  ggaactcga  gagctgctg  240
ctgtggatg  acaggagat  gaatggaag  agacagcca  gtggattaa  tttgaagag  300
aagtggaac  gggtgggga  cgatggagc  aaccccatg  ggccacctt  tccctgcac  360
gcttgtttg  gctgaggac  tgtatggag  aaggatcca  catgcttga  cgggaggcc  420
cctctctcc  acagctggt  gagatgatt  cagaccacc  gatcgagac  ggcctcttg  480
agcccgacc  caaggataa  gtcacctat  cgctgctgc  gaaacaccg  catcaaacc  540
agaaatcca  ccttcggtc  ctggctgac  ttgggaaga  agtctccag  gcaagtagg  600
tgttcagca  ccctgataa  ggtagccca  ccatgaccc  caggaatct  acatcctcc  660
gtctcaatg  catttctga  aaaccagag  aggaccagc  gaagaataa  ttcatgaaa  720
aactgcccc  tgatgcaga  gcttccaac  tgctcgttg  ggaggttga  ttcttggac  780
ctcccttca  tgcctttgt  cgtctacag  aggctgtca  gctgggtgc  ctgactgag  840
tgcctgtgc  cacaaggtt  ttgttcatt  tcttaggtc  aaaggggaa  gccaagtcc  900
accatgaga  cggaagagc  atcgccacc  tgatgtctg  cgaggtgtt  cacgatatc  960
cttacaaag  gaaagatag  cacgacctg  ttgctggca  tgacgagtt  ttagatgaa  1020
tcattgtcc  gccacctgg  gaatgggac  cggcaatca  aatagaacc  ccaaagagc  1080
tcccatcat  tgacaaaag  aagaatatg  actcaggtg  agagaacgt  cagatgaat  1140
gggacacac  tcatgatgg  ggccacgga  gaggaggcc  cggtgactg  gaagaacta  1200
agagaactg  ccggttctg  ggtggatta  ttaaggaca  aaagaggaa  gcaccattt  1260
ttgccagtg  cttttatga  gctttaaat  ttcaggctc  ctcggcaat  ctcttcatc  1320
atctggcga  ggtaaccaa  gccatcact  tcggaggcc  gctcgggga  gccactgac  1380
acatgcagg  tgtgttgga  agtttcctg  gcactgctg  ctctggcgc  atcttttgc  1440
tttttgcgg  tcaaccgct  accatcttg  gtagcacgg  acctgttct  gtgtttgag  1500
ggcttcttt  taacttcag  aaggaccat  gttttgact  cttggagtt  cgtctttgg  1560
ttggcctgt  gtcagcctt  atgtgtctc  tcctggtgg  cactgatgc  agcttcctg  1620
ttcagtact  cacccgttt  acggaagaa  gattctcct  tctgatcag  ttcatcttc  1680
tctatgatg  tttcaagaa  atgatcaag  tggcagatt  ctatcccat  aactctgac  1740
tcagagtgg  ctacaacac  cacttctcc  gtgcttgcc  gccacctga  ccagttaat  1800
tctcagtat  taatgatac  acactagcc  cagaggacc  gccaaccgt  tcttctact  1860
acatgtacc  caatgctac  tttgactgg  cctacttgt  aaagaaaga  tgtgtgaaa  1920
ttggaggaa  gctcgtggg  aacaactgt  acttcgtgc  tgacatcac  ctcatgtcc  1980
tcatcctct  cctgggcac  tacacctct  ctatggcca  gaagaaatt  aaaaccagc  2040
gctattttc  aaccacagc  agaaaactg  tcagcgatt  tgccatcat  ctgtccatt  2100
tcatattct  tgtaataga  gccctcgtc  gtgtggata  tccgaagct  attgtgcca  2160
gtgagttca  gccaacaag  cctcaccgg  gttggtttg  cccaccctt  ggaggaaac  2220
cctggtggg  gtgccttgc  gctgctatc  cggctttgc  agtcaccat  ctgattttc  2280
tggaccagc  aatcacggc  gtgattgtg  acaggaaag  acataagct  aagaaggga  2340
ctggctatc  cctggacct  ttttgggtc  ccatcctca  ggtggtgtg  tccttcatg  2400
ctcttccct  gtatgtggc  gctactgtc  tctccatcg  tcacatcga  agtctgaag  2460
tggagacag  gacttctgc  cctggagaa  aaccaaagt  tctgggagt  agagaacaa  2520
gagtcactg  aacccttgt  tttattctg  ctggcctgt  agtctttat  gctcccatc  2580
tgaagttta  ccccatgcc  gttctgtat  gcgtgttct  gtatatggg  gtggcctca  2640
tgaacggtg  gcagttcat  gaccgtctt  agctgcttc  catgcccct  aagcatcaa  2700
ctgacttca  ctacctgcg  cacgtcccc  tgcgccgag  ccacctgtt  acctccctg  2760
aggtgttgt  cctggctct  ctctggatc  tcaagtcca  agtggctgc  attattttt  2820
cagtcatga  cctggccct  gtagctgtc  gaaaaggta  ggactacct  ttctcccag  2880
acgacctca  cttccttga  gatgtcatt  cagagaagg  caagaaaaa  aaggaggat  2940
agaagaaga  gaaaaagaa  aaaggaagt  tggatagcg  caacgacga  tctgactgc  3000
catactcag  aaaggtccc  agtattaaa  ttccaatgg  catcacgga  cagcaacct  3060
tcctaagtg  taacaaacc  ttggacaga  aaagatcct  aacattcct  gaacgccac  3120
catcatgct  ataaaattc  tttccttga  tcactgggt  tacccagtc  tccaagatc  3180
ccagtgaaa  tcgtgcctc  aattagaat  gaacttgag  ctgaagaca  cgattatct  3240
tggaggaac  agggaacag  aaccacgtt  taacctgtt  gtcattctc  aaactgaca  3300
ttctattgt  aactgttct  atttttttt  gtctatgta  tttaaaaac  tttgtttgg  3360
cactgactg  ataatacag  cactctctc  gcttctctc  tgcataggt  aaaatcaag  3420
caatagtgt  ccttttctt  aaaaaaaaa  3449



<210> 402
<211> 1035
<212> PRT
<213> Rattus norvegicus
<308> AAC40034
<400> 402

Met Ser Thr Glu Asn Val Glu Gly Lys Pro Asn Asn Leu Gly Glu Arg 
  1               5                  10                  15
Gly Arg Ala Arg Ser Ser Thr Phe Leu Arg Val Phe Gln Pro Met Phe 
             20                  25                  30
Asn His Ser Ile Phe Thr Ser Ala Val Ser Pro Ala Ala Glu Arg Ile 
         35                  40                  45
Arg Phe Ile Leu Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu 
     50                  55                  60
Phe Thr Glu Leu Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu 
 65                  70                  75                  80
Trp Lys Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln 
                 85                  90                  95
Gly Gly Glu Arg Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His 
             100                105                110
Ser Leu Phe Glu Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu 
         115                120                125
Asp Arg Glu Ala Ser Ser Leu Pro Gln Leu Val Glu Met Ile Ala Asp 
     130                135                140
His Gln Ile Glu Thr Gly Leu Leu Lys Pro Asp Leu Lys Asp Lys Val 
 145                150                155                160
Thr Tyr Thr Leu Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn 
                 165                170                175
Leu Arg Ser Leu Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg 
             180                185                190
Met Phe Ser Asn Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn 
         195                200                205
Leu Thr Ser Ser Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp 
     210                215                220
Gln Leu Lys Asn Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala 
 225                230                235                240
Ser Asn Val Leu Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile 
                 245                250                255
Ala Phe Val Arg Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu 
             260                265                270
Val Pro Val Pro Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly 
         275                280                285
Lys Ala Lys Ser Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met 
     290                295                300
Ser Asp Glu Val Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His 
 305                310                315                320
Asp Leu Ile Ala Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu 
                 325                330                335
Pro Pro Gly Glu Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser 
             340                345                350
Leu Pro Ser Ser Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn 
         355                360                365
Val Gln Met Asn Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly 
     370                375                380
Gly His Gly Asp Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly 
 385                390                395                400
Gly Leu Ile Lys Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp 
                 405                410                415
Phe Tyr Asp Ala Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile 
             420                425                430
Tyr Leu Ala Thr Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly 
         435                440                445
Asp Ala Thr Asp Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr 
     450                455                460
Ala Val Ser Gly Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr 
 465                470                475                480
Ile Leu Ser Ser Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe 
                 485                490                495
Asn Phe Ser Lys Asp His Ser Phe Asp Tyr Leu Glu Phe Arg Leu Trp 
             500                505                510
Ile Gly Leu Trp Ser Ala Phe Met Cys Leu Ile Leu Val Ala Thr Asp 
         515                520                525
Ala Ser Phe Leu Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe 
     530                535                540
Ser Ser Leu Ile Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met 
 545                550                555                560
Ile Lys Leu Ala Asp Tyr Tyr Pro Ile Asn Ser Asp Phe Arg Val Gly 
                 565                570                575
Tyr Asn Thr His Phe Ser Cys Ala Cys Leu Pro Pro Asp Pro Val Asn 
             580                585                590
Leu Ser Val Ser Asn Asp Thr Thr Leu Ala Pro Glu Asp Leu Pro Thr 
         595                600                605
Val Ser Ser Thr Asp Met Tyr His Asn Ala Thr Phe Asp Trp Ala Tyr 
     610                615                620
Leu Ser Lys Lys Glu Cys Val Lys Phe Gly Gly Lys Leu Val Gly Asn 
 625                630                635                640
Asn Cys Asp Phe Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe 
                 645                650                655
Leu Gly Thr Tyr Thr Ser Ser Met Ala Met Lys Lys Phe Lys Thr Ser 
             660                665                670
Arg Tyr Phe Pro Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile 
         675                680                685
Ile Leu Ser Ile Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val 
     690                695                700
Asp Thr Pro Lys Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro 
 705                710                715                720
His Arg Gly Trp Phe Val Pro Pro Phe Gly Gly Asn Pro Trp Trp Val 
                 725                730                735
Cys Leu Ala Ala Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe 
             740                745                750
Met Asp Gln Gln Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys 
         755                760                765
Leu Lys Lys Gly Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile 
     770                775                780
Leu Met Val Val Cys Ser Phe Met Ala Leu Pro Trp Tyr Val Ala Ala 
 785                790                795                800
Thr Val Ile Ser Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu 
                 805                810                815
Thr Ser Ala Pro Gly Glu Gln Pro Lys Phe Leu Gly Val Arg Glu Gln 
             820                825                830
Arg Val Thr Gly Thr Leu Val Phe Ile Leu Thr Gly Leu Ser Val Phe 
         835                840                845
Met Ala Pro Ile Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val 
     850                855                860
Phe Leu Tyr Met Gly Val Ala Ser Leu Asn Gly Val Gln Phe Met Asp 
 865                870                875                880
Arg Leu Lys Leu Leu Leu Met Pro Leu Lys His Gln Pro Asp Phe Ile 
                 885                890                895
Tyr Leu Arg His Val Pro Leu Arg Arg Val His Leu Phe Thr Ser Leu 
             900                905                910
Gln Val Leu Cys Leu Ala Leu Leu Trp Ile Leu Lys Ser Thr Val Ala 
         915                920                925
Ala Ile Ile Phe Pro Val Met Ile Leu Ala Leu Val Ala Val Arg Lys 
     930                935                940
Gly Met Asp Tyr Leu Phe Ser Gln His Asp Leu Ser Phe Leu Asp Asp 
 945                950                955                960
Val Ile Pro Glu Lys Asp Lys Lys Lys Lys Glu Asp Glu Lys Lys Lys 
                 965                970                975
Lys Lys Lys Lys Gly Ser Leu Asp Ser Asp Asn Asp Asp Ser Asp Cys 
             980                985                990
Pro Tyr Ser Glu Lys Val Pro Ser Ile Lys Ile Pro Met Asp Ile Thr 
         995                1000                1005
Glu Gln Gln Pro Phe Leu Ser Asp Asn Lys Pro Leu Asp Arg Glu Arg 
     1010                1015                1020
Ser Ser Thr Phe Leu Glu Arg His Thr Ser Cys 
 1025                1030                1035



<210> 404
<211> 1079
<212> PRT
<213> Homo sapiens
<308> AAG47773
<400> 404

Met Glu Asp Glu Ala Ala Leu Asp Arg Gly Ala Ser Phe Leu Lys His 
  1               5                  10                  15
Val Cys Asp Glu Glu Glu Val Glu Gly His His Thr Ile Tyr Ile Gly 
             20                  25                  30
Val His Val Pro Lys Ser Tyr Arg Arg Arg Arg Arg His Lys Arg Lys 
         35                  40                  45
Thr Gly His Lys Glu Lys Lys Glu Lys Glu Arg Ile Ser Glu Asn Tyr 
     50                  55                  60
Ser Asp Lys Ser Asp Ile Glu Asn Ala Asp Glu Ser Ser Ser Ser Ile 
 65                  70                  75                  80
Leu Lys Pro Leu Ile Ser Pro Ala Ala Glu Arg Ile Arg Phe Ile Leu 
                 85                  90                  95
Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu Phe Thr Glu Leu 
             100                105                110
Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu Trp Lys Glu Thr 
         115                120                125
Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln Gly Gly Glu Arg 
     130                135                140
Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His Ser Leu Phe Glu 
 145                150                155                160
Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu Asp Arg Glu Ala 
                 165                170                175
Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp His Gln Ile Glu 
             180                185                190
Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val Thr Tyr Thr Leu 
         195                200                205
Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn Leu Arg Ser Leu 
     210                215                220
Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg Met Phe Thr Asn 
 225                230                235                240
Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn Leu Thr Ser Ser 
                 245                250                255
Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp Gln Leu Lys Asn 
             260                265                270
Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala Ser Asn Val Leu 
         275                280                285
Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile Ala Phe Val Arg 
     290                295                300
Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu Val Pro Val Pro 
 305                310                315                320
Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly Lys Ala Lys Ser 
                 325                330                335
Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met Ser Asp Glu Val 
             340                345                350
Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His Asp Leu Ile Ala 
         355                360                365
Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu Pro Pro Gly Glu 
     370                375                380
Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser Leu Pro Ser Ser 
 385                390                395                400
Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn Val Gln Met Asn 
                 405                410                415
Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly Gly His Gly Asp 
             420                425                430
Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly Gly Leu Ile Lys 
         435                440                445
Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp Phe Tyr Asp Ala 
     450                455                460
Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile Tyr Leu Ala Thr 
 465                470                475                480
Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp 
                 485                490                495
Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ser Gly 
             500                505                510
Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser 
         515                520                525
Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe Asn Phe Ser Lys 
     530                535                540
Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp Ile Gly Leu Trp 
 545                550                555                560
Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp Ala Ser Phe Leu 
                 565                570                575
Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe Ser Ser Leu Ile 
             580                585                590
Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met Ile Lys Leu Ala 
         595                600                605
Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu 
     610                615                620
Phe Ser Cys Thr Cys Val Pro Pro Asp Pro Ala Asn Ile Ser Ile Ser 
 625                630                635                640
Asn Asp Thr Thr Leu Ala Pro Glu Tyr Leu Pro Thr Met Ser Ser Thr 
                 645                650                655
Asp Met Tyr His Asn Thr Thr Phe Asp Trp Ala Phe Leu Ser Lys Lys 
             660                665                670
Glu Cys Ser Lys Tyr Gly Gly Asn Leu Val Gly Asn Asn Cys Asn Phe 
         675                680                685
Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe Leu Gly Thr Tyr 
     690                695                700
Thr Ser Ser Met Ala Leu Lys Lys Phe Lys Thr Ser Pro Tyr Phe Pro 
 705                710                715                720
Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile Ile Leu Ser Ile 
                 725                730                735
Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val Asp Thr Pro Lys 
             740                745                750
Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro Asn Arg Gly Trp 
         755                760                765
Phe Val Pro Pro Phe Gly Glu Asn Pro Trp Trp Val Cys Leu Ala Ala 
     770                775                780
Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe Met Asp Arg Gln 
 785                790                795                800
Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys Leu Lys Lys Gly 
                 805                810                815
Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile Leu Met Val Ile 
             820                825                830
Cys Ser Leu Met Ala Leu Pro Trp Tyr Val Ala Ala Thr Val Ile Ser 
         835                840                845
Ile Ala His Ile Asp Ser Leu Arg Met Glu Thr Glu Thr Ser Ala Pro 
     850                855                860
Gly Glu Gln Pro Lys Phe Leu Gly Val Arg Glu Gln Arg Val Thr Gly 
 865                870                875                880
Thr Leu Val Phe Ile Leu Thr Gly Leu Ser Val Phe Met Ala Pro Ile 
                 885                890                895
Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe Leu Tyr Met 
             900                905                910
Gly Val Ala Ser Leu Asn Gly Val Gln Phe Met Asp Arg Leu Lys Leu 
         915                920                925
Leu Leu Met Pro Leu Lys His Gln Pro Asp Phe Ile Tyr Leu Arg His 
     930                935                940
Val Pro Leu Arg Arg Val His Leu Phe Thr Phe Leu Gln Val Leu Cys 
 945                950                955                960
Leu Ala Leu Leu Trp Ile Leu Lys Ser Thr Val Ala Ala Ile Ile Phe 
                 965                970                975
Pro Val Met Ile Leu Ala Leu Val Ala Val Arg Lys Gly Met Asp Tyr 
             980                985                990
Leu Phe Ser Gln His Asp Leu Ser Phe Leu Asp Asp Val Ile Pro Glu 
         995                1000                1005
Lys Asp Lys Lys Lys Lys Glu Asp Glu Lys Lys Lys Lys Lys Lys Lys 
     1010                1015                1020
Gly Ser Leu Asp Ser Asp Asn Asp Asp Ser Asp Cys Pro Tyr Ser Glu 
 1025                1030                1035                1040
Lys Val Pro Ser Ile Lys Ile Pro Met Asp Ile Met Glu Gln Gln Pro 
                 1045                1050                1055
Phe Leu Ser Asp Ser Lys Pro Ser Asp Arg Glu Arg Ser Pro Thr Phe 
             1060                1065                1070
Leu Glu Arg His Thr Ser Cys 
         1075



<210> 405
<211> 3449
<212> DNA
<213> Rattus norvegicus
<308> AF004017
<400> 405

gctttgatc  gttcagata  aggatgtcc  ctgaaaatg  ggaagggaa  cccaataat  60
ttggggaga  aggaagagc  cgaagctcc  ctttcctca  ggttttcca  ccaatgttt  120
accacagta  tttcacttc  gcagtctcc  cggccgcag  acgtatccg  ttcatcttg  180
gagaggaag  tgacagccc  gcacctcct  agctcttca  ggaactcga  gagctgctg  240
ctgtggatg  acaggagat  gaatggaag  agacagcca  gtggattaa  tttgaagag  300
aagtggaac  gggtgggga  cgatggagc  aaccccatg  ggccacctt  tccctgcac  360
gcttgtttg  gctgaggac  tgtatggag  aaggatcca  catgcttga  cgggaggcc  420
cctctctcc  acagctggt  gagatgatt  cagaccacc  gatcgagac  ggcctcttg  480
agcccgacc  caaggataa  gtcacctat  cgctgctgc  gaaacaccg  catcaaacc  540
agaaatcca  ccttcggtc  ctggctgac  ttgggaaga  agtctccag  gcaagtagg  600
tgttcagca  ccctgataa  ggtagccca  ccatgaccc  caggaatct  acatcctcc  660
gtctcaatg  catttctga  aaaccagag  aggaccagc  gaagaataa  ttcatgaaa  720
aactgcccc  tgatgcaga  gcttccaac  tgctcgttg  ggaggttga  ttcttggac  780
ctcccttca  tgcctttgt  cgtctacag  aggctgtca  gctgggtgc  ctgactgag  840
tgcctgtgc  cacaaggtt  ttgttcatt  tcttaggtc  aaaggggaa  gccaagtcc  900
accatgaga  cggaagagc  atcgccacc  tgatgtctg  cgaggtgtt  cacgatatc  960
cttacaaag  gaaagatag  cacgacctg  ttgctggca  tgacgagtt  ttagatgaa  1020
tcattgtcc  gccacctgg  gaatgggac  cggcaatca  aatagaacc  ccaaagagc  1080
tcccatcat  tgacaaaag  aagaatatg  actcaggtg  agagaacgt  cagatgaat  1140
gggacacac  tcatgatgg  ggccacgga  gaggaggcc  cggtgactg  gaagaacta  1200
agagaactg  ccggttctg  ggtggatta  ttaaggaca  aaagaggaa  gcaccattt  1260
ttgccagtg  cttttatga  gctttaaat  ttcaggctc  ctcggcaat  ctcttcatc  1320
atctggcga  ggtaaccaa  gccatcact  tcggaggcc  gctcgggga  gccactgac  1380
acatgcagg  tgtgttgga  agtttcctg  gcactgctg  ctctggcgc  atcttttgc  1440
tttttgcgg  tcaaccgct  accatcttg  gtagcacgg  acctgttct  gtgtttgag  1500
ggcttcttt  taacttcag  aaggaccat  gttttgact  cttggagtt  cgtctttgg  1560
ttggcctgt  gtcagcctt  atgtgtctc  tcctggtgg  cactgatgc  agcttcctg  1620
ttcagtact  cacccgttt  acggaagaa  gattctcct  tctgatcag  ttcatcttc  1680
tctatgatg  tttcaagaa  atgatcaag  tggcagatt  ctatcccat  aactctgac  1740
tcagagtgg  ctacaacac  cacttctcc  gtgcttgcc  gccacctga  ccagttaat  1800
tctcagtat  taatgatac  acactagcc  cagaggacc  gccaaccgt  tcttctact  1860
acatgtacc  caatgctac  tttgactgg  cctacttgt  aaagaaaga  tgtgtgaaa  1920
ttggaggaa  gctcgtggg  aacaactgt  acttcgtgc  tgacatcac  ctcatgtcc  1980
tcatcctct  cctgggcac  tacacctct  ctatggcca  gaagaaatt  aaaaccagc  2040
gctattttc  aaccacagc  agaaaactg  tcagcgatt  tgccatcat  ctgtccatt  2100
tcatattct  tgtaataga  gccctcgtc  gtgtggata  tccgaagct  attgtgcca  2160
gtgagttca  gccaacaag  cctcaccgg  gttggtttg  cccaccctt  ggaggaaac  2220
cctggtggg  gtgccttgc  gctgctatc  cggctttgc  agtcaccat  ctgattttc  2280
tggaccagc  aatcacggc  gtgattgtg  acaggaaag  acataagct  aagaaggga  2340
ctggctatc  cctggacct  ttttgggtc  ccatcctca  ggtggtgtg  tccttcatg  2400
ctcttccct  gtatgtggc  gctactgtc  tctccatcg  tcacatcga  agtctgaag  2460
tggagacag  gacttctgc  cctggagaa  aaccaaagt  tctgggagt  agagaacaa  2520
gagtcactg  aacccttgt  tttattctg  ctggcctgt  agtctttat  gctcccatc  2580
tgaagttta  ccccatgcc  gttctgtat  gcgtgttct  gtatatggg  gtggcctca  2640
tgaacggtg  gcagttcat  gaccgtctt  agctgcttc  catgcccct  aagcatcaa  2700
ctgacttca  ctacctgcg  cacgtcccc  tgcgccgag  ccacctgtt  acctccctg  2760
aggtgttgt  cctggctct  ctctggatc  tcaagtcca  agtggctgc  attattttt  2820
cagtcatga  cctggccct  gtagctgtc  gaaaaggta  ggactacct  ttctcccag  2880
acgacctca  cttccttga  gatgtcatt  cagagaagg  caagaaaaa  aaggaggat  2940
agaagaaga  gaaaaagaa  aaaggaagt  tggatagcg  caacgacga  tctgactgc  3000
catactcag  aaaggtccc  agtattaaa  ttccaatgg  catcacgga  cagcaacct  3060
tcctaagtg  taacaaacc  ttggacaga  aaagatcct  aacattcct  gaacgccac  3120
catcatgct  ataaaattc  tttccttga  tcactgggt  tacccagtc  tccaagatc  3180
ccagtgaaa  tcgtgcctc  aattagaat  gaacttgag  ctgaagaca  cgattatct  3240
tggaggaac  agggaacag  aaccacgtt  taacctgtt  gtcattctc  aaactgaca  3300
ttctattgt  aactgttct  atttttttt  gtctatgta  tttaaaaac  tttgtttgg  3360
cactgactg  ataatacag  cactctctc  gcttctctc  tgcataggt  aaaatcaag  3420
caatagtgt  ccttttctt  aaaaaaaaa  3449



<210> 406
<211> 1035
<212> PRT
<213> Rattus norvegicus
<308> AAC40034
<400> 406

Met Ser Thr Glu Asn Val Glu Gly Lys Pro Asn Asn Leu Gly Glu Arg 
  1               5                  10                  15
Gly Arg Ala Arg Ser Ser Thr Phe Leu Arg Val Phe Gln Pro Met Phe 
             20                  25                  30
Asn His Ser Ile Phe Thr Ser Ala Val Ser Pro Ala Ala Glu Arg Ile 
         35                  40                  45
Arg Phe Ile Leu Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu 
     50                  55                  60
Phe Thr Glu Leu Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu 
 65                  70                  75                  80
Trp Lys Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln 
                 85                  90                  95
Gly Gly Glu Arg Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His 
             100                105                110
Ser Leu Phe Glu Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu 
         115                120                125
Asp Arg Glu Ala Ser Ser Leu Pro Gln Leu Val Glu Met Ile Ala Asp 
     130                135                140
His Gln Ile Glu Thr Gly Leu Leu Lys Pro Asp Leu Lys Asp Lys Val 
 145                150                155                160
Thr Tyr Thr Leu Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn 
                 165                170                175
Leu Arg Ser Leu Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg 
             180                185                190
Met Phe Ser Asn Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn 
         195                200                205
Leu Thr Ser Ser Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp 
     210                215                220
Gln Leu Lys Asn Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala 
 225                230                235                240
Ser Asn Val Leu Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile 
                 245                250                255
Ala Phe Val Arg Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu 
             260                265                270
Val Pro Val Pro Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly 
         275                280                285
Lys Ala Lys Ser Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met 
     290                295                300
Ser Asp Glu Val Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His 
 305                310                315                320
Asp Leu Ile Ala Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu 
                 325                330                335
Pro Pro Gly Glu Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser 
             340                345                350
Leu Pro Ser Ser Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn 
         355                360                365
Val Gln Met Asn Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly 
     370                375                380
Gly His Gly Asp Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly 
 385                390                395                400
Gly Leu Ile Lys Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp 
                 405                410                415
Phe Tyr Asp Ala Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile 
             420                425                430
Tyr Leu Ala Thr Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly 
         435                440                445
Asp Ala Thr Asp Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr 
     450                455                460
Ala Val Ser Gly Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr 
 465                470                475                480
Ile Leu Ser Ser Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe 
                 485                490                495
Asn Phe Ser Lys Asp His Ser Phe Asp Tyr Leu Glu Phe Arg Leu Trp 
             500                505                510
Ile Gly Leu Trp Ser Ala Phe Met Cys Leu Ile Leu Val Ala Thr Asp 
         515                520                525
Ala Ser Phe Leu Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe 
     530                535                540
Ser Ser Leu Ile Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met 
 545                550                555                560
Ile Lys Leu Ala Asp Tyr Tyr Pro Ile Asn Ser Asp Phe Arg Val Gly 
                 565                570                575
Tyr Asn Thr His Phe Ser Cys Ala Cys Leu Pro Pro Asp Pro Val Asn 
             580                585                590
Leu Ser Val Ser Asn Asp Thr Thr Leu Ala Pro Glu Asp Leu Pro Thr 
         595                600                605
Val Ser Ser Thr Asp Met Tyr His Asn Ala Thr Phe Asp Trp Ala Tyr 
     610                615                620
Leu Ser Lys Lys Glu Cys Val Lys Phe Gly Gly Lys Leu Val Gly Asn 
 625                630                635                640
Asn Cys Asp Phe Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe 
                 645                650                655
Leu Gly Thr Tyr Thr Ser Ser Met Ala Met Lys Lys Phe Lys Thr Ser 
             660                665                670
Arg Tyr Phe Pro Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile 
         675                680                685
Ile Leu Ser Ile Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val 
     690                695                700
Asp Thr Pro Lys Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro 
 705                710                715                720
His Arg Gly Trp Phe Val Pro Pro Phe Gly Gly Asn Pro Trp Trp Val 
                 725                730                735
Cys Leu Ala Ala Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe 
             740                745                750
Met Asp Gln Gln Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys 
         755                760                765
Leu Lys Lys Gly Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile 
     770                775                780
Leu Met Val Val Cys Ser Phe Met Ala Leu Pro Trp Tyr Val Ala Ala 
 785                790                795                800
Thr Val Ile Ser Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu 
                 805                810                815
Thr Ser Ala Pro Gly Glu Gln Pro Lys Phe Leu Gly Val Arg Glu Gln 
             820                825                830
Arg Val Thr Gly Thr Leu Val Phe Ile Leu Thr Gly Leu Ser Val Phe 
         835                840                845
Met Ala Pro Ile Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val 
     850                855                860
Phe Leu Tyr Met Gly Val Ala Ser Leu Asn Gly Val Gln Phe Met Asp 
 865                870                875                880
Arg Leu Lys Leu Leu Leu Met Pro Leu Lys His Gln Pro Asp Phe Ile 
                 885                890                895
Tyr Leu Arg His Val Pro Leu Arg Arg Val His Leu Phe Thr Ser Leu 
             900                905                910
Gln Val Leu Cys Leu Ala Leu Leu Trp Ile Leu Lys Ser Thr Val Ala 
         915                920                925
Ala Ile Ile Phe Pro Val Met Ile Leu Ala Leu Val Ala Val Arg Lys 
     930                935                940
Gly Met Asp Tyr Leu Phe Ser Gln His Asp Leu Ser Phe Leu Asp Asp 
 945                950                955                960
Val Ile Pro Glu Lys Asp Lys Lys Lys Lys Glu Asp Glu Lys Lys Lys 
                 965                970                975
Lys Lys Lys Lys Gly Ser Leu Asp Ser Asp Asn Asp Asp Ser Asp Cys 
             980                985                990
Pro Tyr Ser Glu Lys Val Pro Ser Ile Lys Ile Pro Met Asp Ile Thr 
         995                1000                1005
Glu Gln Gln Pro Phe Leu Ser Asp Asn Lys Pro Leu Asp Arg Glu Arg 
     1010                1015                1020
Ser Ser Thr Phe Leu Glu Arg His Thr Ser Cys 
 1025                1030                1035



<210> 408
<211> 1079
<212> PRT
<213> Homo sapiens
<308> AAG47773
<400> 408

Met Glu Asp Glu Ala Ala Leu Asp Arg Gly Ala Ser Phe Leu Lys His 
  1               5                  10                  15
Val Cys Asp Glu Glu Glu Val Glu Gly His His Thr Ile Tyr Ile Gly 
             20                  25                  30
Val His Val Pro Lys Ser Tyr Arg Arg Arg Arg Arg His Lys Arg Lys 
         35                  40                  45
Thr Gly His Lys Glu Lys Lys Glu Lys Glu Arg Ile Ser Glu Asn Tyr 
     50                  55                  60
Ser Asp Lys Ser Asp Ile Glu Asn Ala Asp Glu Ser Ser Ser Ser Ile 
 65                  70                  75                  80
Leu Lys Pro Leu Ile Ser Pro Ala Ala Glu Arg Ile Arg Phe Ile Leu 
                 85                  90                  95
Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu Phe Thr Glu Leu 
             100                105                110
Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu Trp Lys Glu Thr 
         115                120                125
Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln Gly Gly Glu Arg 
     130                135                140
Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His Ser Leu Phe Glu 
 145                150                155                160
Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu Asp Arg Glu Ala 
                 165                170                175
Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp His Gln Ile Glu 
             180                185                190
Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val Thr Tyr Thr Leu 
         195                200                205
Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn Leu Arg Ser Leu 
     210                215                220
Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg Met Phe Thr Asn 
 225                230                235                240
Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn Leu Thr Ser Ser 
                 245                250                255
Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp Gln Leu Lys Asn 
             260                265                270
Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala Ser Asn Val Leu 
         275                280                285
Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile Ala Phe Val Arg 
     290                295                300
Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu Val Pro Val Pro 
 305                310                315                320
Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly Lys Ala Lys Ser 
                 325                330                335
Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met Ser Asp Glu Val 
             340                345                350
Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His Asp Leu Ile Ala 
         355                360                365
Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu Pro Pro Gly Glu 
     370                375                380
Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser Leu Pro Ser Ser 
 385                390                395                400
Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn Val Gln Met Asn 
                 405                410                415
Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly Gly His Gly Asp 
             420                425                430
Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly Gly Leu Ile Lys 
         435                440                445
Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp Phe Tyr Asp Ala 
     450                455                460
Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile Tyr Leu Ala Thr 
 465                470                475                480
Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp 
                 485                490                495
Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ser Gly 
             500                505                510
Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser 
         515                520                525
Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe Asn Phe Ser Lys 
     530                535                540
Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp Ile Gly Leu Trp 
 545                550                555                560
Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp Ala Ser Phe Leu 
                 565                570                575
Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe Ser Ser Leu Ile 
             580                585                590
Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met Ile Lys Leu Ala 
         595                600                605
Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu 
     610                615                620
Phe Ser Cys Thr Cys Val Pro Pro Asp Pro Ala Asn Ile Ser Ile Ser 
 625                630                635                640
Asn Asp Thr Thr Leu Ala Pro Glu Tyr Leu Pro Thr Met Ser Ser Thr 
                 645                650                655
Asp Met Tyr His Asn Thr Thr Phe Asp Trp Ala Phe Leu Ser Lys Lys 
             660                665                670
Glu Cys Ser Lys Tyr Gly Gly Asn Leu Val Gly Asn Asn Cys Asn Phe 
         675                680                685
Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe Leu Gly Thr Tyr 
     690                695                700
Thr Ser Ser Met Ala Leu Lys Lys Phe Lys Thr Ser Pro Tyr Phe Pro 
 705                710                715                720
Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile Ile Leu Ser Ile 
                 725                730                735
Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val Asp Thr Pro Lys 
             740                745                750
Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro Asn Arg Gly Trp 
         755                760                765
Phe Val Pro Pro Phe Gly Glu Asn Pro Trp Trp Val Cys Leu Ala Ala 
     770                775                780
Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe Met Asp Arg Gln 
 785                790                795                800
Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys Leu Lys Lys Gly 
                 805                810                815
Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile Leu Met Val Ile 
             820                825                830
Cys Ser Leu Met Ala Leu Pro Trp Tyr Val Ala Ala Thr Val Ile Ser 
         835                840                845
Ile Ala His Ile Asp Ser Leu Arg Met Glu Thr Glu Thr Ser Ala Pro 
     850                855                860
Gly Glu Gln Pro Lys Phe Leu Gly Val Arg Glu Gln Arg Val Thr Gly 
 865                870                875                880
Thr Leu Val Phe Ile Leu Thr Gly Leu Ser Val Phe Met Ala Pro Ile 
                 885                890                895
Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe Leu Tyr Met 
             900                905                910
Gly Val Ala Ser Leu Asn Gly Val Gln Phe Met Asp Arg Leu Lys Leu 
         915                920                925
Leu Leu Met Pro Leu Lys His Gln Pro Asp Phe Ile Tyr Leu Arg His 
     930                935                940
Val Pro Leu Arg Arg Val His Leu Phe Thr Phe Leu Gln Val Leu Cys 
 945                950                955                960
Leu Ala Leu Leu Trp Ile Leu Lys Ser Thr Val Ala Ala Ile Ile Phe 
                 965                970                975
Pro Val Met Ile Leu Ala Leu Val Ala Val Arg Lys Gly Met Asp Tyr 
             980                985                990
Leu Phe Ser Gln His Asp Leu Ser Phe Leu Asp Asp Val Ile Pro Glu 
         995                1000                1005
Lys Asp Lys Lys Lys Lys Glu Asp Glu Lys Lys Lys Lys Lys Lys Lys 
     1010                1015                1020
Gly Ser Leu Asp Ser Asp Asn Asp Asp Ser Asp Cys Pro Tyr Ser Glu 
 1025                1030                1035                1040
Lys Val Pro Ser Ile Lys Ile Pro Met Asp Ile Met Glu Gln Gln Pro 
                 1045                1050                1055
Phe Leu Ser Asp Ser Lys Pro Ser Asp Arg Glu Arg Ser Pro Thr Phe 
             1060                1065                1070
Leu Glu Arg His Thr Ser Cys 
         1075



<210> 409
<211> 1590
<212> DNA
<213> Rattus norvegicus
<308> AF004218
<400> 409

acgcgtccg  cgttggtgg  accaggctg  ccgctggga  gccgtgggc  gtgggccgg  60
ggtgggcat  gatcaccct  tttctgact  ttgtggcgg  gctgatcca  gcggtctgg  120
tgtggctgg  tactcagag  ttcgtcttc  agagagaag  gatagctca  cttgctcga  180
agtacgcag  gctggacca  gagctggcc  tctctcggc  gatcgtgga  ctgcggagg  240
tgcacccag  ccacgtgct  ccggatgag  agctgcagt  ggtgtttgt  aacgcgggc  300
gctggatgg  cgccatgtg  cttttgcac  cctcgctgt  tgagtacgt  ctgctcttc  360
gcaccgccc  gggctccca  ggccattcg  gacgatact  ggctgagat  tcagatacc  420
tcatctctg  cactttcca  cagtggaga  agggcacca  aaaaagtga  gtctattac  480
caggagaga  ggttgtcca  ggacctgga  aggcaacag  tgtggagtg  ggaccaaac  540
cgtggatgg  ggagtatgg  cggggtgtt  ttccgtcta  cctggcatt  gcacttagt  600
acactattt  cagcaccca  gacttcctc  ccctcttct  tacccttcg  gcctatgcc  660
ggggcctcc  gcttgagct  accacctac  tctttggcc  agacccctg  ccagacagg  720
tgaaggaag  cctgcgagt  gacaggagc  ggcaggacc  catccattt  tctactcgc  780
gggactcat  ttcactgac  gcagcatat  ccatgcaga  aattaagtt  ctgctgtgt  840
aggaaggac  tacatacac  tacatccag  cacagctct  ggggagcaa  gagacgcag  900
gatgctaag  cttgtatgt  ctgtaagat  atgcactca  ctccatcca  agagggtcc  960
cgacgtata  tccaggggg  cgcccagtc  tgtttgaac  cataccacg  gcttgactc  1020
cctgactca  gcttttcca  agcctcctg  tggcattcg  ggctctgag  tagaggatt  1080
gggtagatg  cacagtctg  ctcgccctc  ctctgatgc  gcattccag  agtgatctc  1140
ggtgaagga  aagaggagc  gcccttcgg  ggtcccgtt  gcctgcagc  gtgatgccc  1200
tccctccat  cctttcctc  ccatatgcc  tatctccat  ccagtcccc  gctatgcaa  1260
tgtccctgt  gcttgtcct  catgccccc  gcgaccagc  gggaaagca  aggaatgta  1320
aggaagctg  aggactgaa  gaaggaggt  ctccaccat  gagaccctc  gggttacaa  1380
gggaaagct  gctgatgcc  ggggccagt  cccaaagag  ggacctggg  aagtgagcc  1440
ggctccgag  agccacccc  ttccaaaag  agcctttag  gtatgtgtg  acaccttgt  1500
ggtctccag  catttctgt  gcattctct  tcttcctgt  tctctctgt  aataaaaac  1560
gatcaaaca  taaaaaaaa  aaaaaaaaaa  1590



<210> 410
<211> 223
<212> PRT
<213> Rattus norvegicus
<308> AAD01198
<400> 410

Met Pro Trp Ala Val Gly Arg Arg Trp Ala Trp Ile Thr Leu Phe Leu 
  1               5                  10                  15
Thr Ile Val Ala Val Leu Ile Gln Ala Val Trp Leu Trp Leu Gly Thr 
             20                  25                  30
Gln Ser Phe Val Phe Gln Arg Glu Glu Ile Ala Gln Leu Ala Arg Gln 
         35                  40                  45
Tyr Ala Gly Leu Asp His Glu Leu Ala Phe Ser Arg Leu Ile Val Glu 
     50                  55                  60
Leu Arg Arg Leu His Pro Gly His Val Leu Pro Asp Glu Glu Leu Gln 
 65                  70                  75                  80
Trp Val Phe Val Asn Ala Gly Gly Trp Met Gly Ala Met Cys Leu Leu 
                 85                  90                  95
His Ala Ser Leu Ser Glu Tyr Val Leu Leu Phe Gly Thr Ala Leu Gly 
             100                105                110
Ser His Gly His Ser Gly Arg Tyr Trp Ala Glu Ile Ser Asp Thr Ile 
         115                120                125
Ile Ser Gly Thr Phe His Gln Trp Arg Glu Gly Thr Thr Lys Ser Glu 
     130                135                140
Val Tyr Tyr Pro Gly Glu Thr Val Val His Gly Pro Gly Glu Ala Thr 
 145                150                155                160
Asp Val Glu Trp Gly Pro Asn Thr Trp Met Val Glu Tyr Gly Arg Gly 
                 165                170                175
Val Ile Pro Ser Thr Leu Ala Phe Ala Leu Ser Asp Thr Ile Phe Ser 
             180                185                190
Thr Gln Asp Phe Leu Thr Leu Phe Tyr Thr Leu Arg Ala Tyr Ala Arg 
         195                200                205
Gly Leu Arg Leu Glu Leu Thr Thr Tyr Leu Phe Gly Gln Asp Pro 
     210                215                220



<210> 411
<211> 1641
<212> DNA
<213> Homo sapiens
<308> U75283
<400> 411

ggccccggc  ccctcctga  ctgcgccgt  ccaggccgc  cgccgggat  cagtgggcc  60
tgggccggc  gtgggcgtg  gccgcgctg  tcctggctg  cgcagcggt  ctgacccag  120
tcgtctggc  ctggctggg  acgcagagc  tcgtcttcc  gcgcgaaga  atagcgcag  180
tggcgcggc  gtacgctgg  ctggaccac  agctggcct  ctctcgtct  atcgtggag  240
tgcggcggc  gcacccagg  cacgtgctg  ccgacgagg  gctgcagtg  gtgttcgtg  300
atgcgggtg  ctggatggg  gccatgtgc  ttctgcacg  ctcgctgtc  gagtatgtg  360
tgctcttcg  caccgcctt  ggctcccgc  gccactcgg  gcgctactg  gctgagatc  420
cggatacca  catctctgg  accttccac  agtggagag  gggcaccac  aaaagtgag  480
tcttctacc  aggggagac  gtagtacac  ggcctggtg  ggcaacagc  gtggagtgg  540
ggccaaaca  atggatggt  gagtacggc  ggggcgtca  cccatccac  ctggccttc  600
cgctggccg  cactgtctt  agcacccag  acttcctca  cctcttcta  actcttcgc  660
cctatgctc  gggcctccg  cttgagctc  ccacctacc  ctttggcca  gacccttga  720
cagccaggc  tgaaggaag  cctgcggat  gacaggagc  ggcaggccc  cacatatcc  780
cttgctgga  cccatgttt  cagacaggg  catacacca  gcagatcct  agttcctgc  840
gtatgagca  ggatatcca  gcttatgta  ccaaacaca  agacccatg  gaacaaatg  900
gacacatat  gatactgag  cctgtgtgt  cagtaggac  atgcactca  acccatctg  960
agagggagc  cccggtata  caagggagc  agttgtgtt  agacacaca  atcacagct  1020
gactcacta  ctgaggcct  tccatagct  cacagcttc  cacctcctc  ccaccaaac  1080
ggggttcta  agttaagga  gggggaggg  attatactg  ctcagtctg  ctcctcaac  1140
cagcagcaa  ttgagggga  gagggggaa  aggagctgc  ttttggagg  ccccttcac  1200
tgcagctat  atgcccttc  ccttctccc  tgtcctcac  atatgcctt  tccccattc  1260
actcccctg  tatgcaagt  cccctgtgg  ttgtcccca  ccccctcag  aacaaagct  1320
agctgggga  cgagagtaa  ttgaagaat  cttgaagtc  gcgtcttcc  ttccagaaa  1380
acccccatt  ttcctttgg  ggtatgatg  ggaagctgg  ttcagccca  gacccacca  1440
tgaggagag  atctagaca  gtgggccta  ttccaaggg  cccttcctg  cctggagaa  1500
gccttttac  cacacacaa  acatacaca  acacacaca  acacatatc  cagttttca  1560
acagcccct  ctgcattct  tgtccatct  tctgtttct  ttaataaag  tttgttgat  1620
tgttaaaaa  aaaaaaaaa  a  1641



<210> 412
<211> 223
<212> PRT
<213> Homo sapiens
<308> NP_005857
<400> 412

Met Gln Trp Ala Val Gly Arg Arg Trp Ala Trp Ala Ala Leu Leu Leu 
  1               5                  10                  15
Ala Val Ala Ala Val Leu Thr Gln Val Val Trp Leu Trp Leu Gly Thr 
             20                  25                  30
Gln Ser Phe Val Phe Gln Arg Glu Glu Ile Ala Gln Leu Ala Arg Gln 
         35                  40                  45
Tyr Ala Gly Leu Asp His Glu Leu Ala Phe Ser Arg Leu Ile Val Glu 
     50                  55                  60
Leu Arg Arg Leu His Pro Gly His Val Leu Pro Asp Glu Glu Leu Gln 
 65                  70                  75                  80
Trp Val Phe Val Asn Ala Gly Gly Trp Met Gly Ala Met Cys Leu Leu 
                 85                  90                  95
His Ala Ser Leu Ser Glu Tyr Val Leu Leu Phe Gly Thr Ala Leu Gly 
             100                105                110
Ser Arg Gly His Ser Gly Arg Tyr Trp Ala Glu Ile Ser Asp Thr Ile 
         115                120                125
Ile Ser Gly Thr Phe His Gln Trp Arg Glu Gly Thr Thr Lys Ser Glu 
     130                135                140
Val Phe Tyr Pro Gly Glu Thr Val Val His Gly Pro Gly Glu Ala Thr 
 145                150                155                160
Ala Val Glu Trp Gly Pro Asn Thr Trp Met Val Glu Tyr Gly Arg Gly 
                 165                170                175
Val Ile Pro Ser Thr Leu Ala Phe Ala Leu Ala Asp Thr Val Phe Ser 
             180                185                190
Thr Gln Asp Phe Leu Thr Leu Phe Tyr Thr Leu Arg Ser Tyr Ala Arg 
         195                200                205
Gly Leu Arg Leu Glu Leu Thr Thr Tyr Leu Phe Gly Gln Asp Pro 
     210                215                220



<210> 413
<211> 2099
<212> DNA
<213> Rattus norvegicus
<308> AF004811
<400> 413

gcacccggt  ctcccgagt  cttgccgaa  tgtactgcg  gctcagagc  gcccgacag  60
ttccagcca  acttcagca  ctcctccct  gccgcacca  gccgaagac  atcagtgtt  120
gtgtaacca  catggatgc  gagctggag  ttgccattc  gcccaacac  actggcaag  180
agctgtttg  ccaggtggt  aaaactatt  gtttgagag  agtttggtt  tttggtctg  240
agtaccagg  cacaaaagc  ttctctact  ggctgaaac  caataagaa  gtgactgca  300
aggatgtcc  gaaggaaag  ccgttgctc  tcaagttcc  ggccaagtt  tatccagag  360
atgtgtctg  agaactgat  caggatatc  cccagcgcc  gttctttct  caagtgaag  420
agggcattc  caatgatga  atttattgt  cacctgaaa  cgctgtgct  ttggcgtcc  480
atgccgtcc  gtctaagta  ggtgacttc  acaaggaag  gcacaagtc  ggctacctg  540
ctggagata  gttgcttcc  caaagagtc  tggagcagc  caaactcaa  aaggaccag  600
gggaagagc  gatccaggt  tggcatgag  aacaccggg  catgctcag  gaggatgct  660
tcctggaat  tctcaagat  gctcaggac  tggagatgt  tggtgtgaa  tatttcagc  720
tcaagaaca  gaaaggctc  gagctgtgg  tgggtgtgg  tgccttggg  ctcaacatc  780
atgagcaga  tgacagatt  actcctaag  ttggcttcc  ttggagtga  atcaggaac  840
tctctttca  tgataagaa  tttgtcatc  agcctattg  caaaaaggc  ccggacttt  900
tgttctatg  tcctcggct  cggattaac  aaaggatct  ggccctgtg  atggggaat  960
atgagctgt  catgcgtcg  cgaaagcct  acaccattg  ggtgcagca  atgaaggcc  1020
aggctcgag  agagaagca  cagaagcag  tggagcgtg  tctactgga  aatgagaag  1080
agaagcgtg  gctggctga  aaagagaag  agaagattg  acgggagaa  gaagagctg  1140
tggagaagc  gaagcagat  gaggagcag  ccaagaagg  tcagcaaga  ctggaagaa  1200
agacccgca  ggccctaga  cttgagcag  aacggaagc  tgcccagag  gaggctgaa  1260
agctggcca  ggagcgtca  gaagctgaa  aagccaagg  ggccctgct  caggcttct  1320
gggaccaga  gaagactca  gaacagctg  cttcagaaa  ggcagagct  acagcacgg  1380
tctcccagt  ggaaatggc  cgaaagaag  aggagagtg  ggctgagga  tgccaccaa  1440
aggcccaga  ggtccagga  gacttggag  agactcgcg  tgagctgaa  acagccatg  1500
gtacccctc  tgtggcaga  cctgctgag  atgaacatg  tgagcagga  gagaatgga  1560
ccgaggcca  tgctgagct  cgggctgat  ctatggcca  ggaccgcag  gaggaagaa  1620
gtaccactg  ggcagagaa  aatgagcgt  tgcagaagc  tcttaaggc  cttacttca  1680
agctggcca  tgcccgaga  gagtccaag  agactacca  tgacatgat  catgctgag  1740
acatgcgac  gggacgaga  aaatacaag  ccctgcgcc  gatccggca  ggcaatacc  1800
aacagcgca  tgatgaatt  gagtccatg  agtgggcgc  cagccgtta  ggacccctc  1860
tccttcttc  ttgtccccc  cactcctat  gttttgcct  actaacacc  tgctggagc  1920
actaactag  aaagccttg  agccatacc  aacattcag  atgaccatg  gaccaaatt  1980
agtttccct  ttcatatcc  tgggcaaac  aatggccca  ctgtgtagc  aatggaacc  2040
cctcttcct  ctttgtcac  ctcattcaa  atagctctc  agaatagac  atttccccc  2099



<210> 414
<211> 160
<212> PRT
<213> Rattus norvegicus
<308> P31977
<400> 414

Lys Ile Ala Leu Leu Glu Glu Ala Arg Arg Arg Lys Glu Asp Glu Val 
  1               5                  10                  15
Glu Glu Trp Gln His Arg Ala Lys Glu Ala Gln Asp Asp Leu Val Lys 
             20                  25                  30
Thr Lys Glu Glu Leu His Leu Val Met Thr Ala Pro Pro Pro Pro Pro 
         35                  40                  45
Pro Pro Val Tyr Glu Pro Val Asn Tyr His Val Gln Glu Gly Leu Gln 
     50                  55                  60
Asp Glu Gly Ala Glu Pro Met Gly Tyr Ser Ala Glu Leu Ser Ser Glu 
 65                  70                  75                  80
Gly Ile Leu Asp Asp Arg Asn Glu Glu Lys Arg Ile Thr Glu Ala Glu 
                 85                  90                  95
Lys Asn Glu Arg Val Gln Arg Gln Pro Leu Thr Leu Ser Asn Glu Leu 
             100                105                110
Ser Gln Ala Arg Asp Glu Asn Lys Arg Thr His Asn Asp Ile Ile His 
         115                120                125
Asn Glu Asn Met Arg Gln Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln 
     130                135                140
Ile Arg Gln Gly Asn Thr Lys Gln Arg Ile Asp Glu Phe Glu Ala Met 
 145                150                155                160



<210> 415
<211> 3879
<212> DNA
<213> Homo sapiens
<308> M69066
<400> 415

ggcacgagg  cagccgaat  caagccgtg  gtactgcgt  ctcagcact  cccgacagt  60
ctagctaaa  ttcgccaac  ccgctgcct  tgccgccac  atgcccaaa  cgatcagtg  120
gcgtgtgac  accatggat  cagagctgg  gtttgccat  cagcccaac  ccaccggga  180
gcagctatt  gaccaggtg  tgaaaacta  tggcttgag  gaagtttgg  tctttggtc  240
gcagtacca  gacactaaa  gtttctcca  ctggctgaa  ctcaataag  aggtgactg  300
ccaggatgt  cggaaggaa  gccccctgc  ctttaagtt  cgtgccaag  tctaccctg  360
ggatgtgtc  gaggaattg  ttcaggaca  cactcagcg  ctgttcttt  tgcaagtga  420
agagggcat  ctcaatgat  atatttact  cccgcctga  accgctgtg  tgctggcct  480
gtatgctgt  cagtctaag  atggcgact  caataagga  gtgcataag  ctggctacc  540
ggccggaga  aagttgctc  cgcagagag  cctggaaca  cacaaactc  acaaggacc  600
gtgggagga  cggatccag  tgtggcatg  ggaacaccg  ggcatgctc  gggaggatg  660
tgtcctgga  tatctgaag  ttgctcaag  tctggagat  tatggtgtg  actacttca  720
catcaagaa  aagaaaggc  cagagctgt  gctgggggt  gatgccctg  gtctcaaca  780
ctatgagca  aatgacaga  taactccca  gataggctt  ccctggagt  aaatcagga  840
catctcttt  aatgataag  aatttgtca  caagcccat  gacaaaaaa  ccccggact  900
cgtcttcta  gctccccgg  tgcggatta  caagcggat  ttggccttg  gcatgggga  960
ccatgaact  tacatgcgc  gtcgcaagc  tgataccat  gaggtgcag  agatgaagg  1020
acaggcccg  gaggagaag  accagaagc  gatggagcg  gctatgctg  aaaatgaga  1080
gaagaagcg  gaaatggca  agaaggaga  agagaagat  gaacgggag  aggaggagc  1140
gatggagag  ctgaagcag  tcgaggaac  gactaagaa  gctcagcaa  aactggaag  1200
acagacccg  agggctctg  aacttgagc  ggaacggaa  cgtgcccag  gcgaggctg  1260
aaagctggc  aaggagcgt  aagaagctg  agaggccaa  gaggccttg  tgcaggcct  1320
ccgggacca  aaaaagact  aggaacagc  ggccttgga  atggcagag  tgacagctc  1380
aatctccca  ctggagatg  cccgacaga  gaaggagag  gaggctgtg  agtggcagc  1440
gaaggccca  atggtacag  aagacttgg  gaagacccg  gctgagctg  agactgcca  1500
gagtacacc  catgtggca  agcctgctg  gaatgagca  gatgagcag  atgagaatg  1560
ggcagaggc  agtgctgac  tacgggctg  tgctatggc  aaggaccgc  gtgaggagg  1620
acgtaccac  gaggcagag  agaatgagc  tgtgcagaa  cacctgaag  ccctcactt  1680
ggagctggc  aatgccaga  atgagtcca  gaagactgc  aatgacatg  tccatgctg  1740
gaacatgcg  ctgggccga  acaaataca  gaccctgcg  cagatccgg  agggcaaca  1800
caagcagcg  attgacgaa  ttgagtcta  gtaatgggc  cccagcctc  agggacccc  1860
cctcccttt  tccttgtcc  cacactcct  cacctaact  acctaactc  tactgtgct  1920
gagccacta  ctagagcag  cctggagtc  tgccaagca  ttaatgtag  catgggacc  1980
aacctagcc  cttagcccc  acccacttc  ctgggcaaa  gaatggctc  ctatggtgc  2040
aatggaacc  cctttctct  ctctgttcc  ttgaatctg  atggctaga  tatcctact  2100
ctccagcct  gaggtactt  ccacttgat  ttgcaaatg  ccttacact  actgttgtc  2160
tatgggagt  aagtgtgga  taggttgga  gctagctcc  ctcctctcc  ctccactgt  2220
ttcttcagg  cctgagatt  cacggtgga  tgtatgcgg  ctaggaatg  gacaggacc  2280
agatatctt  tccagggat  tcaactgac  taaaatttg  cctcccatc  cgtttagag  2340
tatttaggc  ttgtaacga  tgggggaat  aaaagatgt  cagtcattt  tgtttctac  2400
tcccagatc  gatctgttg  aaactcagc  tcaataagc  ttgtcgttg  ctttaggga  2460
tcaatttct  cccagggtg  atgggggaa  tggtgcctt  aagaccttc  ccaaacata  2520
tagaagggc  ttggccatt  tattgtggc  aggctgagt  gaagatcct  ccccaattc  2580
ttgtaggag  ataggccgg  ctaaagtga  ctctatggg  agatctacc  cttacttat  2640
attccagat  tgcagtcac  tcgtgggat  tgcccctcc  tgcttcaat  cccaaatcc  2700
ctccagcta  aacagtagg  atgagtacc  aaaagctca  ccagcccca  caggactct  2760
gtgaaaaga  aggatatgt  cacacctag  gtcagtatt  tccctgcta  gggttttag  2820
tctcttccc  tctcagagc  acttgggcc  tagctcctg  tccacagcc  tcccagcct  2880
ggcatctag  gcttgatgc  agtaggctc  actagggag  gagtgcaaa  agctgagta  2940
ggtgagaga  gcctgtgcc  tgatccaag  ttactcaac  ctctcaggt  accaaaatc  3000
ccttctcat  actcccctc  aagaggtga  tgggccctg  ctctgtttg  caaacctct  3060
acccaggtc  tgacaccag  tgttctgtc  cttggagct  taaaccaga  agctgctgg  3120
ggattctgg  ctagtccct  ccacacccc  accccttgc  ctcaaccca  gagcatcca  3180
ctccttctc  gtctcatgt  tgctcttct  ctttctaca  tattatgta  tctactgat  3240
tctaaatat  gatttctgc  ttccttgct  atgcaccat  agaagatat  agtcttggg  3300
caggatgat  ttggcctca  tactttacc  cccccacac  tggaaagca  atactatat  3360
acaaaatga  attttgcca  aattattaa  ataagaagc  ttcagtatt  gtgatgtca  3420
ctgtcacta  aggtcatac  atccattct  aaagtactt  ttatttgtt  ttattatta  3480
tgtttgtct  ctccccagg  ttcagtccc  caaggggcc  tcctgtccc  ccatgcagt  3540
ccccctagc  tagagcctc  ctcaattcc  cctggccac  accccccac  ctgtgcctg  3600
ccttgagga  tcttgtgtg  attgctgtg  attagctca  ttggtgata  gtcctatat  3660
ggctaaatt  aaacctgga  ttgtggggc  atctattaa  agctgcctt  aagtcagta  3720
cttaccctt  gggaggctg  gggaaaagg  tagattttg  attcagggg  tttttgtgt  3780
ctttttggg  ttttaaaaa  ttgtttttg  aggggttta  gctcaatcc  tgttctatt  3840
cagtgccaa  aaaatttag  tgacttcaa  aaaaaaaaa  3879



<210> 416
<211> 576
<212> PRT
<213> Homo sapiens
<308> P26038
<400> 416

Pro Lys Thr Ile Ser Val Arg Val Thr Thr Met Asp Ala Glu Leu Glu 
  1               5                  10                  15
Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln Val 
             20                  25                  30
Val Lys Thr Ile Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln Tyr 
         35                  40                  45
Gln Asp Thr Lys Gly Phe Ser Thr Trp Leu Lys Leu Asn Lys Lys Val 
     50                  55                  60
Thr Ala Gln Asp Val Arg Lys Glu Ser Pro Leu Leu Phe Lys Phe Arg 
 65                  70                  75                  80
Ala Lys Phe Tyr Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Asp Ile 
                 85                  90                  95
Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Asn Asp 
             100                105                110
Asp Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr Ala 
         115                120                125
Val Gln Ser Lys Tyr Gly Asp Phe Asn Lys Glu Val His Lys Ser Gly 
     130                135                140
Tyr Leu Ala Gly Asp Lys Leu Leu Pro Gln Arg Val Leu Glu Gln His 
 145                150                155                160
Lys Leu Asn Lys Asp Gln Trp Glu Glu Arg Ile Gln Val Trp His Glu 
                 165                170                175
Glu His Arg Gly Met Leu Arg Glu Asp Ala Val Leu Glu Tyr Leu Lys 
             180                185                190
Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ser Ile Lys 
         195                200                205
Asn Lys Lys Gly Ser Glu Leu Trp Leu Gly Val Asp Ala Leu Gly Leu 
     210                215                220
Asn Ile Tyr Glu Gln Asn Asp Arg Leu Thr Pro Lys Ile Gly Phe Pro 
 225                230                235                240
Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val Ile 
                 245                250                255
Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro Arg 
             260                265                270
Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His Glu 
         275                280                285
Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln Met 
     290                295                300
Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Met Glu Arg Ala 
 305                310                315                320
Met Leu Glu Asn Glu Lys Lys Lys Arg Glu Met Ala Glu Lys Glu Lys 
                 325                330                335
Glu Lys Ile Glu Arg Glu Lys Glu Glu Leu Met Glu Arg Leu Lys Gln 
             340                345                350
Ile Glu Glu Gln Thr Lys Lys Ala Gln Gln Glu Leu Glu Glu Gln Thr 
         355                360                365
Arg Arg Ala Leu Glu Leu Glu Gln Glu Arg Lys Arg Ala Gln Ser Glu 
     370                375                380
Ala Glu Lys Leu Ala Lys Glu Arg Gln Glu Ala Glu Glu Ala Lys Glu 
 385                390                395                400
Ala Leu Leu Gln Ala Ser Arg Asp Gln Lys Lys Thr Gln Glu Gln Leu 
                 405                410                415
Ala Leu Glu Met Ala Glu Leu Thr Ala Arg Ile Ser Gln Leu Glu Met 
             420                425                430
Ala Arg Gln Lys Lys Glu Ser Glu Ala Val Glu Trp Gln Gln Lys Ala 
         435                440                445
Gln Met Val Gln Glu Asp Leu Glu Lys Thr Arg Ala Glu Leu Lys Thr 
     450                455                460
Ala Met Ser Thr Pro His Val Ala Glu Pro Ala Glu Asn Glu Gln Asp 
 465                470                475                480
Glu Gln Asp Glu Asn Gly Ala Glu Ala Ser Ala Asp Leu Arg Ala Asp 
                 485                490                495
Ala Met Ala Lys Asp Arg Ser Glu Glu Glu Arg Thr Thr Glu Ala Glu 
             500                505                510
Lys Asn Glu Arg Val Gln Lys His Leu Lys Ala Leu Thr Ser Glu Leu 
         515                520                525
Ala Asn Ala Arg Asp Glu Ser Lys Lys Thr Ala Asn Asp Met Ile His 
     530                535                540
Ala Glu Asn Met Arg Leu Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln 
 545                550                555                560
Ile Arg Gln Gly Asn Thr Lys Gln Arg Ile Asp Glu Phe Glu Ser Met 
                 565                570                575



<210> 417
<211> 1342
<212> DNA
<213> Rattus norvegicus
<308> AF006664
<400> 417

ggacagcgg  caccatgcg  gaaggctat  cccgggggt  ggcagtgcc  ctctctgcc  60
cccacctgg  gctgtgaga  cggcgtcgc  accatgttc  ccagccctg  gctcacaca  120
acgcccttc  cagtcaaag  catcctgaa  ctggagcag  agcagcgca  cctggcggc  180
ggggacctg  ctgcgcgcc  cgaggccac  ctggcgccc  cctcctgca  gctggccgc  240
ttcaagccg  acggctact  aggccccga  gcggcagcg  ccggcctgg  agagctgcg  300
gcggagctg  gccccgcgc  ttcgccccc  aagtgctct  ctgctttcc  aaccgcccc  360
acattttat  cgcgagcct  cggtgaccc  gaccccgcc  aggaccctc  ggcggataa  420
aaagagctg  gcgcgctgc  gaaggcggt  gagctggac  aagccgaga  agacggcgc  480
gagaggcga  gaccacggc  gcgacggaa  ccacgcgtg  tcttctcgc  ggcgcaggt  540
tatgagctg  agcggcgct  caagcaaca  cggtacctg  cgcccgctg  gcgcgacca  600
ctggccagc  tgctgaagc  cacgtccac  caggtcaag  tctggttcc  gaaccgccg  660
tacaagtgt  agcgacagc  gcaggacca  actctggag  tgctggggc  gccgccgcc  720
cccgcgcgc  ggatcgcgg  gccggtgtt  gtgcgcgac  ggaagccct  cctggggga  780
tcggcggcc  acgctcccg  ctacggcct  ggtctcaac  cctacggct  caacgccta  840
ccctatccc  gctacggtg  cgcggcctg  agtcccgcc  acagctgcg  cgcgtaccc  900
gccgcgccc  ccgccgcgc  cgccccagc  gccagcgcc  acagcaact  cgtgaactt  960
ggcgtcggg  acttgaaca  ggtgcagag  cccgggatg  cacagggca  ttcgggcgt  1020
tccacgctg  acggcatcc  agcctggta  ggaaagggc  cgtctgggg  accccggac  1080
gactcccac  tttaggaga  gggcgatga  tccggggat  gaaaggctc  cactgtgtc  1140
tgtccctcg  atttcacac  cacacttgc  caggcctgg  acctttctc  gatccatcc  1200
cttttgttg  cctaacctg  tgcctcggt  ctgggaaag  ccttcaggg  caaaggcac  1260
ctccacgga  tccatatca  gacccggag  ctgggccgg  cgcccgggc  ctgggtgcc  1320
tgccggcgc  caccggccg  gg  1342



<210> 418
<211> 318
<212> PRT
<213> Rattus norvegicus
<308> O35767
<400> 418

Met Phe Pro Ser Pro Ala Leu Thr His Thr Pro Phe Ser Val Lys Asp 
  1               5                  10                  15
Ile Leu Asn Leu Glu Gln Gln Gln Arg Ser Leu Ala Ala Gly Asp Leu 
             20                  25                  30
Ser Ala Arg Leu Glu Ala Thr Leu Ala Pro Ala Ser Cys Met Leu Ala 
         35                  40                  45
Ala Phe Lys Pro Asp Gly Tyr Ser Gly Pro Glu Ala Ala Ala Pro Gly 
     50                  55                  60
Leu Ala Glu Leu Arg Ala Glu Leu Gly Pro Ala Pro Ser Pro Pro Lys 
 65                  70                  75                  80
Cys Ser Pro Ala Phe Pro Thr Ala Pro Thr Phe Tyr Pro Arg Ala Tyr 
                 85                  90                  95
Gly Asp Pro Asp Pro Ala Lys Asp Pro Arg Ala Asp Lys Lys Glu Leu 
             100                105                110
Cys Ala Leu Gln Lys Ala Val Glu Leu Asp Lys Ala Glu Thr Asp Gly 
         115                120                125
Ala Glu Arg Arg Arg Pro Arg Arg Arg Arg Lys Pro Arg Val Leu Phe 
     130                135                140
Ser Gln Ala Gln Val Tyr Glu Leu Glu Arg Arg Phe Lys Gln Gln Arg 
 145                150                155                160
Tyr Leu Ser Pro Ala Glu Arg Asp Gln Leu Ala Ser Val Leu Lys Leu 
                 165                170                175
Thr Ser Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys Cys 
             180                185                190
Lys Arg Gln Arg Gln Asp Gln Thr Leu Glu Leu Leu Gly Pro Pro Pro 
         195                200                205
Pro Pro Ala Arg Arg Ile Ala Val Pro Val Leu Val Arg Asp Gly Lys 
     210                215                220
Pro Cys Leu Gly Asp Ser Ala Ala Tyr Ala Pro Ala Tyr Gly Leu Gly 
 225                230                235                240
Leu Asn Ala Tyr Gly Tyr Asn Ala Tyr Pro Tyr Pro Gly Tyr Gly Gly 
                 245                250                255
Ala Ala Cys Ser Pro Ala Tyr Ser Cys Ala Ala Tyr Pro Ala Ala Pro 
             260                265                270
Pro Ala Ala His Ala Pro Ala Ala Ser Ala Asn Ser Asn Phe Val Asn 
         275                280                285
Phe Gly Val Gly Asp Leu Asn Thr Val Gln Ser Pro Gly Met Pro Gln 
     290                295                300
Gly Asn Ser Gly Val Ser Thr Leu His Gly Ile Arg Ala Trp 
 305                310                315



<210> 419
<211> 1585
<212> DNA
<213> Homo sapiens
<308> U34962
<400> 419

gcctggtcc  gcctctcct  ccccttgtg  tcagcgcta  ctgctgccc  gacacatcc  60
gagctggcc  acgggtgcg  gggcgggcg  cggcaccat  cagggaagc  gccaggggc  120
gtgggcagc  ccgctttct  ccgcccacc  ggcgctgtg  gactggcgc  gccaccatg  180
tccccagcc  tgctctcac  cccacgccc  tctcagtca  agacatcct  aacctggaa  240
agcagcagc  cagcctggc  gccgccgga  agctctctg  ccgcctgga  gcgaccctg  300
cgccctcct  ctgcatgct  gccgccttc  agccagagg  ctacgctgg  cccgaggcg  360
ctgcgccgg  cctcccaga  ctgcgcgca  agctgggcc  cgcgccttc  ccggccaag  420
gtgcgtctg  ctttcccgc  gcccccgcc  tctatccac  tgcctacag  gaccccgac  480
cagccaagg  ccctagagc  gaaaagaaa  agctgtgcg  gctgcagaa  gcggtggag  540
tggagaaga  agaggcgga  aacgcggag  ggccccggg  gcgacggcg  aggaagccg  600
gcgtgctct  ctcgcaggc  caggtctat  agctggagc  gcgcttcaa  cagcagcgg  660
acctgtcgg  ccccgaacg  gaccagctg  ccagcgtgc  gaaactcac  tccacgcag  720
tcaagatct  gttccagaa  cggcgctac  agtgcaagc  gcagcggca  gaccagact  780
tggagctgg  ggggctgcc  ccgccgccg  cgccgcctg  ccgcaggat  gcggtgcca  840
tgctggtgc  cgatggcaa  ccatgccta  gggactcgg  gccctacgc  cctgcctac  900
gcgtgggcc  caatcccta  ggttataac  cctaccccg  ctatccggg  tacggcggc  960
cggcctgca  ccctggcta  agctgcact  ccgcttacc  cgccgggcc  tccccagcg  1020
agccggcca  tgccgccgc  aacaacaac  tcgtgaact  cggcgtcgg  gacttgaat  1080
cggttcaga  ccccgggat  ccgcagagc  actcgggag  gtccacgct  catggtatc  1140
gagcctggt  gggaaggga  ccgcgtggc  cgaccctga  cgatcccac  tcaacagct  1200
cctgactct  gtggggaga  ggggctccc  acatgaccc  gagtcccct  gattttgca  1260
tcactcctg  ggagaccta  gaacttttt  tgtcccacg  gcgtttgtt  ttgcgcacg  1320
gagagtttg  ggcggcgat  atgcagcgt  caatgagtg  tcctgcagc  tggtgtctt  1380
gctgtcccc  caggagtgc  ctccgagag  ccatgggca  ccccggttg  aactgggac  1440
gagctcggg  acgcagggc  tgagatctg  ccgcccatt  cgcgagcca  ggccgggcg  1500
ccgggcctt  gctatctcg  cgtcgcccg  ccacgcacc  acccgtatt  atgttttta  1560
ctattgctg  aagaaatga  gatcc  1585



<210> 420
<211> 324
<212> PRT
<213> Homo sapiens
<308> P52952
<400> 420

Met Phe Pro Ser Pro Ala Leu Thr Pro Thr Pro Phe Ser Val Lys Asp 
  1               5                  10                  15
Ile Leu Asn Leu Glu Gln Gln Gln Arg Ser Leu Ala Ala Ala Gly Glu 
             20                  25                  30
Leu Ser Ala Arg Leu Glu Ala Thr Leu Ala Pro Ser Ser Cys Met Leu 
         35                  40                  45
Ala Ala Phe Lys Pro Glu Ala Tyr Ala Gly Pro Glu Ala Ala Ala Pro 
     50                  55                  60
Gly Leu Pro Glu Leu Arg Ala Glu Leu Gly Arg Ala Pro Ser Pro Ala 
 65                  70                  75                  80
Lys Cys Ala Ser Ala Phe Pro Ala Ala Pro Ala Phe Tyr Pro Arg Ala 
                 85                  90                  95
Tyr Ser Asp Pro Asp Pro Ala Lys Asp Pro Arg Ala Glu Lys Lys Glu 
             100                105                110
Leu Cys Ala Leu Gln Lys Ala Val Glu Leu Glu Lys Thr Glu Ala Asp 
         115                120                125
Asn Ala Glu Arg Pro Arg Ala Arg Arg Arg Arg Lys Pro Arg Val Leu 
     130                135                140
Phe Ser Gln Ala Gln Val Tyr Glu Leu Glu Arg Arg Phe Lys Gln Gln 
 145                150                155                160
Arg Tyr Leu Ser Ala Pro Glu Arg Asp Gln Leu Ala Ser Val Leu Lys 
                 165                170                175
Leu Thr Ser Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys 
             180                185                190
Cys Lys Arg Gln Arg Gln Asp Gln Thr Leu Glu Leu Val Gly Leu Pro 
         195                200                205
Pro Pro Pro Pro Pro Pro Ala Arg Arg Ile Ala Val Pro Val Leu Val 
     210                215                220
Arg Asp Gly Lys Pro Cys Leu Gly Asp Ser Ala Pro Tyr Ala Pro Ala 
 225                230                235                240
Tyr Gly Val Gly Leu Asn Pro Tyr Gly Tyr Asn Ala Tyr Pro Ala Tyr 
                 245                250                255
Pro Gly Tyr Gly Gly Ala Ala Cys Ser Pro Gly Tyr Ser Cys Thr Ala 
             260                265                270
Ala Tyr Pro Ala Gly Pro Ser Pro Ala Gln Pro Ala Thr Ala Ala Ala 
         275                280                285
Asn Asn Asn Phe Val Asn Phe Gly Val Gly Asp Leu Asn Ala Val Gln 
     290                295                300
Ser Pro Gly Ile Pro Gln Ser Asn Ser Gly Val Ser Thr Leu His Gly 
 305                310                315                320
Ile Arg Ala Trp 
                 325



<210> 421
<211> 1342
<212> DNA
<213> Rattus norvegicus
<308> AF006664
<400> 421

ggacagcgg  caccatgcg  gaaggctat  cccgggggt  ggcagtgcc  ctctctgcc  60
cccacctgg  gctgtgaga  cggcgtcgc  accatgttc  ccagccctg  gctcacaca  120
acgcccttc  cagtcaaag  catcctgaa  ctggagcag  agcagcgca  cctggcggc  180
ggggacctg  ctgcgcgcc  cgaggccac  ctggcgccc  cctcctgca  gctggccgc  240
ttcaagccg  acggctact  aggccccga  gcggcagcg  ccggcctgg  agagctgcg  300
gcggagctg  gccccgcgc  ttcgccccc  aagtgctct  ctgctttcc  aaccgcccc  360
acattttat  cgcgagcct  cggtgaccc  gaccccgcc  aggaccctc  ggcggataa  420
aaagagctg  gcgcgctgc  gaaggcggt  gagctggac  aagccgaga  agacggcgc  480
gagaggcga  gaccacggc  gcgacggaa  ccacgcgtg  tcttctcgc  ggcgcaggt  540
tatgagctg  agcggcgct  caagcaaca  cggtacctg  cgcccgctg  gcgcgacca  600
ctggccagc  tgctgaagc  cacgtccac  caggtcaag  tctggttcc  gaaccgccg  660
tacaagtgt  agcgacagc  gcaggacca  actctggag  tgctggggc  gccgccgcc  720
cccgcgcgc  ggatcgcgg  gccggtgtt  gtgcgcgac  ggaagccct  cctggggga  780
tcggcggcc  acgctcccg  ctacggcct  ggtctcaac  cctacggct  caacgccta  840
ccctatccc  gctacggtg  cgcggcctg  agtcccgcc  acagctgcg  cgcgtaccc  900
gccgcgccc  ccgccgcgc  cgccccagc  gccagcgcc  acagcaact  cgtgaactt  960
ggcgtcggg  acttgaaca  ggtgcagag  cccgggatg  cacagggca  ttcgggcgt  1020
tccacgctg  acggcatcc  agcctggta  ggaaagggc  cgtctgggg  accccggac  1080
gactcccac  tttaggaga  gggcgatga  tccggggat  gaaaggctc  cactgtgtc  1140
tgtccctcg  atttcacac  cacacttgc  caggcctgg  acctttctc  gatccatcc  1200
cttttgttg  cctaacctg  tgcctcggt  ctgggaaag  ccttcaggg  caaaggcac  1260
ctccacgga  tccatatca  gacccggag  ctgggccgg  cgcccgggc  ctgggtgcc  1320
tgccggcgc  caccggccg  gg  1342



<210> 422
<211> 318
<212> PRT
<213> Rattus norvegicus
<308> O35767
<400> 422

Met Phe Pro Ser Pro Ala Leu Thr His Thr Pro Phe Ser Val Lys Asp 
  1               5                  10                  15
Ile Leu Asn Leu Glu Gln Gln Gln Arg Ser Leu Ala Ala Gly Asp Leu 
             20                  25                  30
Ser Ala Arg Leu Glu Ala Thr Leu Ala Pro Ala Ser Cys Met Leu Ala 
         35                  40                  45
Ala Phe Lys Pro Asp Gly Tyr Ser Gly Pro Glu Ala Ala Ala Pro Gly 
     50                  55                  60
Leu Ala Glu Leu Arg Ala Glu Leu Gly Pro Ala Pro Ser Pro Pro Lys 
 65                  70                  75                  80
Cys Ser Pro Ala Phe Pro Thr Ala Pro Thr Phe Tyr Pro Arg Ala Tyr 
                 85                  90                  95
Gly Asp Pro Asp Pro Ala Lys Asp Pro Arg Ala Asp Lys Lys Glu Leu 
             100                105                110
Cys Ala Leu Gln Lys Ala Val Glu Leu Asp Lys Ala Glu Thr Asp Gly 
         115                120                125
Ala Glu Arg Arg Arg Pro Arg Arg Arg Arg Lys Pro Arg Val Leu Phe 
     130                135                140
Ser Gln Ala Gln Val Tyr Glu Leu Glu Arg Arg Phe Lys Gln Gln Arg 
 145                150                155                160
Tyr Leu Ser Pro Ala Glu Arg Asp Gln Leu Ala Ser Val Leu Lys Leu 
                 165                170                175
Thr Ser Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys Cys 
             180                185                190
Lys Arg Gln Arg Gln Asp Gln Thr Leu Glu Leu Leu Gly Pro Pro Pro 
         195                200                205
Pro Pro Ala Arg Arg Ile Ala Val Pro Val Leu Val Arg Asp Gly Lys 
     210                215                220
Pro Cys Leu Gly Asp Ser Ala Ala Tyr Ala Pro Ala Tyr Gly Leu Gly 
 225                230                235                240
Leu Asn Ala Tyr Gly Tyr Asn Ala Tyr Pro Tyr Pro Gly Tyr Gly Gly 
                 245                250                255
Ala Ala Cys Ser Pro Ala Tyr Ser Cys Ala Ala Tyr Pro Ala Ala Pro 
             260                265                270
Pro Ala Ala His Ala Pro Ala Ala Ser Ala Asn Ser Asn Phe Val Asn 
         275                280                285
Phe Gly Val Gly Asp Leu Asn Thr Val Gln Ser Pro Gly Met Pro Gln 
     290                295                300
Gly Asn Ser Gly Val Ser Thr Leu His Gly Ile Arg Ala Trp 
 305                310                315



<210> 423
<211> 1585
<212> DNA
<213> Homo sapiens
<308> U34962
<400> 423

gcctggtcc  gcctctcct  ccccttgtg  tcagcgcta  ctgctgccc  gacacatcc  60
gagctggcc  acgggtgcg  gggcgggcg  cggcaccat  cagggaagc  gccaggggc  120
gtgggcagc  ccgctttct  ccgcccacc  ggcgctgtg  gactggcgc  gccaccatg  180
tccccagcc  tgctctcac  cccacgccc  tctcagtca  agacatcct  aacctggaa  240
agcagcagc  cagcctggc  gccgccgga  agctctctg  ccgcctgga  gcgaccctg  300
cgccctcct  ctgcatgct  gccgccttc  agccagagg  ctacgctgg  cccgaggcg  360
ctgcgccgg  cctcccaga  ctgcgcgca  agctgggcc  cgcgccttc  ccggccaag  420
gtgcgtctg  ctttcccgc  gcccccgcc  tctatccac  tgcctacag  gaccccgac  480
cagccaagg  ccctagagc  gaaaagaaa  agctgtgcg  gctgcagaa  gcggtggag  540
tggagaaga  agaggcgga  aacgcggag  ggccccggg  gcgacggcg  aggaagccg  600
gcgtgctct  ctcgcaggc  caggtctat  agctggagc  gcgcttcaa  cagcagcgg  660
acctgtcgg  ccccgaacg  gaccagctg  ccagcgtgc  gaaactcac  tccacgcag  720
tcaagatct  gttccagaa  cggcgctac  agtgcaagc  gcagcggca  gaccagact  780
tggagctgg  ggggctgcc  ccgccgccg  cgccgcctg  ccgcaggat  gcggtgcca  840
tgctggtgc  cgatggcaa  ccatgccta  gggactcgg  gccctacgc  cctgcctac  900
gcgtgggcc  caatcccta  ggttataac  cctaccccg  ctatccggg  tacggcggc  960
cggcctgca  ccctggcta  agctgcact  ccgcttacc  cgccgggcc  tccccagcg  1020
agccggcca  tgccgccgc  aacaacaac  tcgtgaact  cggcgtcgg  gacttgaat  1080
cggttcaga  ccccgggat  ccgcagagc  actcgggag  gtccacgct  catggtatc  1140
gagcctggt  gggaaggga  ccgcgtggc  cgaccctga  cgatcccac  tcaacagct  1200
cctgactct  gtggggaga  ggggctccc  acatgaccc  gagtcccct  gattttgca  1260
tcactcctg  ggagaccta  gaacttttt  tgtcccacg  gcgtttgtt  ttgcgcacg  1320
gagagtttg  ggcggcgat  atgcagcgt  caatgagtg  tcctgcagc  tggtgtctt  1380
gctgtcccc  caggagtgc  ctccgagag  ccatgggca  ccccggttg  aactgggac  1440
gagctcggg  acgcagggc  tgagatctg  ccgcccatt  cgcgagcca  ggccgggcg  1500
ccgggcctt  gctatctcg  cgtcgcccg  ccacgcacc  acccgtatt  atgttttta  1560
ctattgctg  aagaaatga  gatcc  1585



<210> 424
<211> 324
<212> PRT
<213> Homo sapiens
<308> P52952
<400> 424

Met Phe Pro Ser Pro Ala Leu Thr Pro Thr Pro Phe Ser Val Lys Asp 
  1               5                  10                  15
Ile Leu Asn Leu Glu Gln Gln Gln Arg Ser Leu Ala Ala Ala Gly Glu 
             20                  25                  30
Leu Ser Ala Arg Leu Glu Ala Thr Leu Ala Pro Ser Ser Cys Met Leu 
         35                  40                  45
Ala Ala Phe Lys Pro Glu Ala Tyr Ala Gly Pro Glu Ala Ala Ala Pro 
     50                  55                  60
Gly Leu Pro Glu Leu Arg Ala Glu Leu Gly Arg Ala Pro Ser Pro Ala 
 65                  70                  75                  80
Lys Cys Ala Ser Ala Phe Pro Ala Ala Pro Ala Phe Tyr Pro Arg Ala 
                 85                  90                  95
Tyr Ser Asp Pro Asp Pro Ala Lys Asp Pro Arg Ala Glu Lys Lys Glu 
             100                105                110
Leu Cys Ala Leu Gln Lys Ala Val Glu Leu Glu Lys Thr Glu Ala Asp 
         115                120                125
Asn Ala Glu Arg Pro Arg Ala Arg Arg Arg Arg Lys Pro Arg Val Leu 
     130                135                140
Phe Ser Gln Ala Gln Val Tyr Glu Leu Glu Arg Arg Phe Lys Gln Gln 
 145                150                155                160
Arg Tyr Leu Ser Ala Pro Glu Arg Asp Gln Leu Ala Ser Val Leu Lys 
                 165                170                175
Leu Thr Ser Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys 
             180                185                190
Cys Lys Arg Gln Arg Gln Asp Gln Thr Leu Glu Leu Val Gly Leu Pro 
         195                200                205
Pro Pro Pro Pro Pro Pro Ala Arg Arg Ile Ala Val Pro Val Leu Val 
     210                215                220
Arg Asp Gly Lys Pro Cys Leu Gly Asp Ser Ala Pro Tyr Ala Pro Ala 
 225                230                235                240
Tyr Gly Val Gly Leu Asn Pro Tyr Gly Tyr Asn Ala Tyr Pro Ala Tyr 
                 245                250                255
Pro Gly Tyr Gly Gly Ala Ala Cys Ser Pro Gly Tyr Ser Cys Thr Ala 
             260                265                270
Ala Tyr Pro Ala Gly Pro Ser Pro Ala Gln Pro Ala Thr Ala Ala Ala 
         275                280                285
Asn Asn Asn Phe Val Asn Phe Gly Val Gly Asp Leu Asn Ala Val Gln 
     290                295                300
Ser Pro Gly Ile Pro Gln Ser Asn Ser Gly Val Ser Thr Leu His Gly 
 305                310                315                320
Ile Arg Ala Trp 
                 325



<210> 425
<211> 447
<212> DNA
<213> Rattus norvegicus
<308> AF007554
<400> 425

gcagtgtgc  agtgccgcc  aaagagcta  gggcagctg  acctctttc  aacccggga  60
acctaccat  ctatgagtg  atatcctac  taccacact  acggacgct  tgtgccccc  120
gccactacc  aacgtagcc  ctatgaaga  gtttcgaca  gcaatggca  tagcggtct  180
tcttacacc  acccggctg  ggcaaccac  tcggccaac  tgtaggagc  agtcaccct  240
cccactcgg  cagtggcag  tggctccag  agtccactc  ctcagtggt  gctgccaga  300
ccctgcact  tgatctggg  tggtgagcc  ggactcctg  taggctgat  acagccttc  360
tcagaggct  tgtcaccac  ttagcctgg  gaagcccag  cctgccctg  gggacactg  420
ggtagtggt  gctctcaga  agactga  447



<210> 426
<211> 2238
<212> DNA
<213> Homo sapiens
<308> X52228
<400> 426

gaattccct  gctgcttga  tctgttctg  cccctcccc  cccatttca  caccaccat  60
acaccgggc  cccagtctc  tttcttcct  ctgctgctc  tcacagtgc  tacagttgt  120
acaggttct  gtcatgcaa  ctctacccc  ggtggagaa  aggagactt  ggctaccca  180
agaagttca  tgcccagct  tactgagaa  aatgctgtg  gtatgacca  cagcgtact  240
tccagccac  gccccggtt  aggctcctc  accactcag  gacaggatg  cactctggc  300
ccggccacg  aaccagctt  aggttcagc  gccacctgg  gacaggatg  cacctcggt  360
ccagtcacc  ggccagccc  gggctccac  accccgcca  cccacgatg  cacctcagc  420
ccggacaac  agccagccc  gggctccac  gccccccca  cccacggtg  cacctcggc  480
ccggacacc  ggccgcccc  gggctccac  gccccccca  cccacggtg  cacctcggc  540
ccggacacc  ggccgcccc  gggctccac  gcgcccgca  cccacggtg  cacctcggc  600
ccggacacc  ggccggccc  gggctccac  gccccccca  cccatggtg  cacctcggc  660
ccggacaac  ggcccgcct  gggctccac  gcccctcca  tccacaatg  cacctcggc  720
tcaggctct  catcaggct  agcttctac  ctggtgcac  acggcacct  tgccagggc  780
accacaacc  cagccagca  gagcactcc  ttctcaatt  ccagccacc  ctctgatac  840
cctaccacc  ttgccagcc  tagcaccaa  actgatgcc  gtagcactc  ccatagcac  900
gtacctcct  tcacctcct  caatcacag  acttctccc  agttgtcta  tggggtctc  960
ttctttttc  tgtcttttc  catttcaaa  ctccagttt  attcctctc  ggaagatcc  1020
agcaccgac  actaccaag  gctgcagag  gacatttct  aaatggtga  tatcggcct  1080
tccttcccc  tgctcccct  aagcagcca  cagaactgt  cacaccctt  gcatcaagc  1140
tgagtcctt  ccctctcac  ccagttttt  cagatttat  aacaagggg  ttttctggg  1200
ctctccaat  ttaagttca  gtacagttc  gggtgtgga  ccagtgtgg  ggttggagg  1260
ttgggtggt  gtcatgacc  taggaggga  tggtcgcac  taaggttgg  ggaagagtc  1320
tgagccaga  ctgggaccc  tggctgaag  gcccatttc  ctgtgacca  gccaggatc  1380
gtggtggta  aattgactc  ggccttccg  gaaggtacc  tcaatgtcc  cgacgtgga  1440
acacagttc  atcagtata  aacggaagc  gcctctcga  ataacctga  gatctcaga  1500
gtcagcggt  aggctactt  cctggctgc  gcccagcac  atgccgggg  cctctcctt  1560
cagtgcctg  gtccccgct  tttccttag  gctggcagc  ggaggggcg  ctcctctgg  1620
agactgccc  gaccactgc  tttcctttt  gtgagtgat  tgccatttc  tttctctgc  1680
cagtctggg  ctggggtgc  aggctgggg  atcgcgctg  tggtgctgg  ctgtgttct  1740
gttgcgctg  ccattgtct  tctcattgc  ttggtgagt  cagtccctg  ccctgatca  1800
agccccccg  tagaaggca  tccatggcc  gccataacc  cctatctcc  caggctgtc  1860
gtcagtgcc  ccgaaagaa  tacgggcag  tggacatct  tccagcccg  gatacctac  1920
atcctatga  cgagtaccc  acctaccac  cccatgggc  ctatgtgcc  cctagcagt  1980
ccgatcgta  cccctatga  aaggtgaga  tggccccac  ggccagggg  agcagaggg  2040
ttggctggg  aaggattct  aagggggta  ttggaaaac  caaagagct  ggaagaggt  2100
agaagtggc  tgaagtgag  aggggaggg  ctggaaagg  tgaggggca  aggtcagag  2160
agttttggg  gacaggcct  ggaggagac  atggaagaa  ggggccctc  aaagggagt  2220
gccccactg  cagaattc  2238



<210> 427
<211> 1255
<212> PRT
<213> Homo sapiens
<308> Q16615
<400> 427

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
  1               5                  10                  15
Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
             20                  25                  30
Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
         35                  40                  45
Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
     50                  55                  60
Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
 65                  70                  75                  80
Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                 85                  90                  95
Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
             100                105                110
Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
         115                120                125
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
     130                135                140
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
 145                150                155                160
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                 165                170                175
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
             180                185                190
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
         195                200                205
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
     210                215                220
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
 225                230                235                240
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                 245                250                255
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
             260                265                270
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
         275                280                285
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
     290                295                300
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
 305                310                315                320
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                 325                330                335
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
             340                345                350
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
         355                360                365
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
     370                375                380
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
 385                390                395                400
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                 405                410                415
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
             420                425                430
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
         435                440                445
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
     450                455                460
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
 465                470                475                480
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                 485                490                495
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
             500                505                510
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
         515                520                525
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
     530                535                540
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
 545                550                555                560
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                 565                570                575
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
             580                585                590
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
         595                600                605
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
     610                615                620
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
 625                630                635                640
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                 645                650                655
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
             660                665                670
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
         675                680                685
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
     690                695                700
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
 705                710                715                720
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                 725                730                735
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
             740                745                750
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
         755                760                765
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
     770                775                780
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
 785                790                795                800
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                 805                810                815
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
             820                825                830
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
         835                840                845
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
     850                855                860
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
 865                870                875                880
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                 885                890                895
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
             900                905                910
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
         915                920                925
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn 
     930                935                940
Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser 
 945                950                955                960
Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly 
                 965                970                975
Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe 
             980                985                990
Ser Ile Pro Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His 
         995                1000                1005
Ser Thr Lys Thr Asp Ala Ser Ser Thr His His Ser Ser Val Pro Pro 
     1010                1015                1020
Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val 
 1025                1030                1035                1040
Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser 
                 1045                1050                1055
Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp 
             1060                1065                1070
Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly 
         1075                1080                1085
Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr 
     1090                1095                1100
Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln 
 1105                1110                1115                1120
Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile 
                 1125                1130                1135
Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser 
             1140                1145                1150
Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys 
         1155                1160                1165
Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys 
     1170                1175                1180
Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg 
 1185                1190                1195                1200
Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly 
                 1205                1210                1215
Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val 
             1220                1225                1230
Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val 
         1235                1240                1245
Ala Ala Ala Ser Ala Asn Leu 
     1250                1255



<210> 428
<211> 2742
<212> DNA
<213> Rattus norvegicus
<308> AF007583
<400> 428

cagcagcct  gccctctga  ttgatattt  ccagacccg  ccagcatgg  tgtcctgaa  60
ccaatgact  tgggaattt  tctccaact  ttcttctgc  ccatcgtgt  gcagccaac  120
ttcatcaac  gtgtcctcc  aatctcagc  gcccttcct  gcctggatc  gaagaaacg  180
ggcaaccac  aagcatgct  cctactgat  cccccgcca  ccccactct  cccaccgcc  240
ttcttcaga  gcagccgaa  cccgcttct  tccccagac  tgaagaatc  tctggaact  300
gaggcctcc  catcaccct  catgcaagg  tctctaggc  ctcctggcc  ccctgggcc  360
cagggtcca  ctgggcttc  tggcaaggc  ggaccaaag  gagaaaagg  ggatcttgg  420
cgcccagga  ggaagggta  acctggacc  ccaggtgtt  ctggcgagc  cgggcccgt  480
ggctggcca  gccctgaag  acccagggg  gaaaaaggc  acgtgggta  gatgggtct  540
ccagggtca  gaggaccga  gggctctaa  ggcttccct  gatccagag  ggaaaaggg  600
tccagaggt  aaagagggg  cttgggtcc  aaaggagaa  agggtttcc  tggatttcc  660
ggaatgctg  ggcagaaag  tgaaatggg  ccaaaggga  aatctggga  agcaggaca  720
cggggcccc  caggaagac  agggaaacg  ggcaagcag  gtcagaagg  agacagtgg  780
attatgggc  caccaggca  acctgggcc  tctggtcaa  ctggccgtc  aggtcctcc  840
gggccccca  gacccccat  tgcaggaca  cttgtaatg  gactcaaag  ggaaagagg  900
tttccaggg  ccccgggaa  atgcctttg  ggaccccct  cgaatgtga  taacccctc  960
tatggggac  ccatgtatg  gcgcggctc  cctcgagtt  ctgcgattt  tgtggtcaa  1020
aaccaggag  agcttgaga  gctgaacac  caaaatgcc  ttgcctttc  aagagacca  1080
cgatctctg  acttcaaag  tagccttgg  tggctcccc  tccagctaa  ccctttcta  1140
ccagtgggt  tacaccata  agcagcatg  cacctgtgt  gggatgggg  cctgcagcc  1200
ggggaggaa  gtgacgatg  taacccgga  gtgagtgac  gctgcattg  ctgtcatcg  1260
gcctactgt  gagacggtt  tcggcaccg  ggcgtggag  actgtgacg  ctctgactt  1320
ggctacctg  agtgcgaga  ctatctccc  ggatcatac  gagaacttc  gtgcaccca  1380
tattgctcc  tcgactcca  accctgccg  tacttcacg  gagaggctg  agggacagg  1440
gggctgtgg  ccatggacc  gttggctgt  tctctaccc  tcacatcaa  ctggccttg  1500
cctctcctg  gacagtgcc  tttgacctt  atgtgacaa  acaaggata  attcttgct  1560
ctacgacat  cttttgact  cgtatgact  gaagttttg  accactgaa  cctgtctta  1620
ttctaagaa  cagaatcct  ctatacccc  ccctggaaa  ttccccatc  cctccaatc  1680
ggctaaaca  ctggctgta  tgcctgatc  cttctggaa  gatgctggc  gaagcgtgg  1740
tttggctta  cactgttaa  catacaggc  tctacaggc  tggcgtggt  cgttctggt  1800
taccaggtt  aggggtgct  gtgaacagg  ttctgcacc  ccaagcaca  ctgttccga  1860
cccaaagcg  gccagctgc  gggtctctc  agatttaag  accacatca  aggaggtga  1920
aaattctct  ggtgcagct  ccagcttca  acctgctga  gggaccctt  agctggctg  1980
agcctggat  aacttcatg  tgatcagtc  ggggtacga  agagccaca  ggcccaagc  2040
tggtcccag  aagagggtg  aggctcagc  gagtcactg  catgtgacc  ctaccagaa  2100
agaaacctt  ttccttccc  aagttctct  aggcaccat  tgaccttgt  cttctctct  2160
caccttgac  tctgtcttg  cagtgccct  ttgcaacgt  cctgtgtga  agtctcacc  2220
ctcatgccc  cccatggcc  gtgctgctg  ttcctcatg  tggcttccc  ggcttgggc  2280
ccactgcca  gtccttggc  gcaggacgc  ccggtgact  tcttccatg  ccatcttgc  2340
taccccttg  tccctcact  tgtgcccaa  ctcttcctt  atcctggga  tctttttcc  2400
aagccctgc  tttctgaga  ctgccttcc  atatttcat  aatggggtt  ggctctatt  2460
ggggaaaca  cgctttttg  ccccctccc  aatgcgcgc  cctgccttg  cccactacc  2520
aggctgcct  tgggctgtg  aaagctctt  agtgagccc  agccttggg  attcagcag  2580
tggcacctt  tcacccagc  agtccgagc  gtgaatggt  tttcctgag  gaaatcagc  2640
tgaggnnnn  ttcaggggc  gacagctat  tatttacta  tctgggact  ctgggtggg  2700
aaacaagaa  taaaggtga  tcttggctg  gaaaaaaaa  aa  2742



<210> 429
<211> 458
<212> PRT
<213> Rattus norvegicus
<308> O35167
<400> 429

Met Ala Val Leu Asn Pro Met Thr Leu Gly Ile Tyr Leu Gln Leu Phe 
  1               5                  10                  15
Phe Cys Ser Ile Val Ser Gln Pro Thr Phe Ile Asn Ser Val Leu Pro 
             20                  25                  30
Ile Ser Ala Ala Leu Pro Gly Leu Asp Gln Lys Lys Arg Gly Asn His 
         35                  40                  45
Lys Ala Cys Cys Leu Leu Met Pro Pro Pro Pro Pro Leu Phe Pro Pro 
     50                  55                  60
Pro Phe Phe Arg Gly Ser Arg Ser Pro Leu Leu Ser Pro Asp Met Lys 
 65                  70                  75                  80
Asn Leu Leu Glu Leu Glu Ala Ser Pro Ser Pro Cys Met Gln Gly Ser 
                 85                  90                  95
Leu Gly Ser Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Leu Pro 
             100                105                110
Gly Lys Ala Gly Pro Lys Gly Glu Lys Gly Asp Leu Gly Arg Pro Gly 
         115                120                125
Arg Lys Gly Arg Pro Gly Pro Pro Gly Val Pro Gly Glu Pro Gly Pro 
     130                135                140
Val Gly Trp Pro Gly Pro Glu Gly Pro Arg Gly Glu Lys Gly Asp Val 
 145                150                155                160
Gly Met Met Gly Leu Pro Gly Ser Arg Gly Pro Met Gly Ser Lys Gly 
                 165                170                175
Phe Pro Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Glu Arg Gly Asp 
             180                185                190
Leu Gly Pro Lys Gly Glu Lys Gly Phe Pro Gly Phe Pro Gly Met Leu 
         195                200                205
Gly Gln Lys Gly Glu Met Gly Pro Lys Gly Glu Ser Gly Ile Ala Gly 
     210                215                220
His Arg Gly Pro Thr Gly Arg Pro Gly Lys Arg Gly Lys Gln Gly Gln 
 225                230                235                240
Lys Gly Asp Ser Gly Ile Met Gly Pro Pro Gly Lys Pro Gly Pro Ser 
                 245                250                255
Gly Gln Pro Gly Arg Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Ser 
             260                265                270
Ala Gly Gln Leu Val Met Gly Leu Lys Gly Glu Arg Gly Phe Pro Gly 
         275                280                285
Pro Pro Gly Arg Cys Leu Cys Gly Pro Pro Ala Asn Val Asn Asn Pro 
     290                295                300
Ser Tyr Gly Asp Pro Met Tyr Gly Arg Gly Ser Pro Arg Val Pro Ala 
 305                310                315                320
Ile Phe Val Val Asn Asn Gln Glu Glu Leu Glu Lys Leu Asn Thr Gln 
                 325                330                335
Asn Ala Ile Ala Phe Arg Arg Asp Gln Arg Ser Leu Tyr Phe Lys Asp 
             340                345                350
Ser Leu Gly Trp Leu Pro Ile Gln Leu Thr Pro Phe Tyr Pro Val Gly 
         355                360                365
Leu His His Lys Ala Ala Trp His Leu Cys Gly Asp Gly Val Leu Gln 
     370                375                380
Pro Gly Glu Glu Cys Asp Asp Gly Asn Pro Asp Val Ser Asp Gly Cys 
 385                390                395                400
Ile Asp Cys His Arg Ala Tyr Cys Gly Asp Gly Tyr Arg His Arg Gly 
                 405                410                415
Val Glu Asp Cys Asp Gly Ser Asp Phe Gly Tyr Leu Lys Cys Glu Thr 
             420                425                430
Tyr Leu Pro Gly Ser Tyr Gly Glu Leu Arg Cys Thr Gln Tyr Cys Ser 
         435                440                445
Ile Asp Ser Thr Pro Cys Arg Tyr Phe Thr 
     450                455



<210> 430
<211> 2909
<212> DNA
<213> Homo sapiens
<308> NM_080539
<400> 430

cacacgcac  cacacacac  caaacacac  cgcacgcaa  cagcagtga  gaagagaaa  60
gcagagata  gcaaggctc  gcagcagcc  cctttctaa  ttgaccctc  ccagaccct  120
gccagcatg  ttgtcctga  tccaatgac  ttgggaatt  atcttcagc  tttcttcct  180
tctatcgtg  ctcagccga  tttcatcaa  agcgttctt  tcttcagag  tggccgaag  240
ccgcttctc  ccccagaca  gaagaatct  atgctggaa  tggagacct  gcagtcccc  300
tgcatgcaa  gctcgctag  ctcccctgg  cctcccggc  cccagggtc  accggggct  360
cctggcaag  caggaccaa  gggagaaaa  ggggagctt  gccgaccag  aaggaaggg  420
agacctggc  ccccaggtg  tcctggcat  cctgggccc  tcggttggc  aggccctga  480
ggacccagg  gtgaaaaag  tgacctggg  atgatgggc  tgccagggt  aagaggacc  540
atgggctcc  agggctacc  tggatccag  ggggaaaag  gatccagag  tgaaaaggg  600
gacctgggt  ccaaaggag  aaagggttt  ccaggattt  ctggaatgt  ggggcagaa  660
ggtgaaatg  gtccaaaag  tgaacctgg  atagcagga  accgaggac  cacaggaag  720
ccaggaaaa  gaggcaagc  gggacagaa  ggggatagt  gagttatgg  cccaccagg  780
aagcctggg  cttctggtc  acctggccg  ccggggccc  caggccccc  acctgcagg  840
caacttata  tgggaccca  aggggaaag  ggatttccc  ggcctccag  aagatgtct  900
tgtggaccc  ctatgaatg  gaataaccc  tcctacggg  aatctgtgt  tgggcccag  960
tccccgcga  ttcctgtga  ttttgtggt  aacaaccag  aggagcttg  gaggctgaa  1020
acccaaaac  ccattgcct  ccgcagaga  cagagatct  tgtacttca  ggacagcct  1080
ggctggctc  ccatccagc  gaccccttt  taccctgtg  attacactg  agaccagca  1140
ggcacctgt  gggatgggc  cctgcagcc  ggggaggag  gtgacgacg  taacagcga  1200
gtgggtgac  actgcatcc  ctgtcaccg  gcctactgt  gagatggtc  ccggcatga  1260
ggtgtggag  actgtgacg  ctctgactt  ggctacctg  catgcgaga  ctatctccc  1320
gggtcatat  gagacctgc  atgcaccca  tactgctac  tcgactcca  gccctgccg  1380
tacttcacc  gagggccgt  aggagaagg  gggctgcgc  ccacagaac  ggcagcagc  1440
tctccactg  catcaaact  gccatgtcc  ggccccgtc  ccaccaacc  ttgtgtgac  1500
aaaacaagg  caaattcct  ctactaaga  atgctgtta  ctcagtctg  ctggaagaa  1560
ttaggacca  tgcatcctg  cttaatcca  ggtactgga  aaccttcca  atgcccaac  1620
tgagacctg  tccccatcg  taccatttg  ccaaacaac  ggctacaat  ctcttcctc  1680
tctggaatg  tgctgaccc  ggccgtgga  ttggctgag  actgttaga  acacataga  1740
ctgcaggct  ttttagtat  ttttgatct  tttggggaa  ctggagtac  ggcctctcc  1800
cccctgacc  ccgaaacgt  caggcattc  cactcacac  gggcagccc  ctgtcgggt  1860
tctctaggc  tatgaacca  aaagcaggg  agtgggcac  ttctctcgg  gtggctcac  1920
gctttgaac  tgccaaagg  cccctcgac  ggccacagc  cagcccagc  tgacgtgga  1980
gtggctgcc  aggaaaaga  ttaactgtg  aaaagtact  agaacccac  tgacccagg  2040
ttgccccaa  cagaggcta  agaagaggc  cctcttctc  gtgtttccc  aaggggcgg  2100
tcttgtggt  tcaaaatct  tggcaccat  ttgacctct  ggctctctc  gcactttgc  2160
ccctgtctc  aaaatgtcc  tcatgtcca  ttcctgtcc  ggagactca  gaggactgt  2220
tgacctgca  aagcccaca  ctgggcagg  tgttggtgt  tccttggtc  ttaggcaga  2280
actcccctg  gtccccgat  tagggccag  tgcagaggg  tctctctag  cagagcgtt  2340
ctggccaga  ctctacctc  ttgcctcct  ctgacccct  acagcgtcc  gtggcattt  2400
tttcatgtc  gcatattgc  tagccttgt  ctcctgtgt  cctgagctc  tcccttttc  2460
ataagatta  tagtcgtgc  tgtctgtga  ctgcctttc  tcaccattt  tcctgagta  2520
ggcttagtt  tattctgga  agacatctc  aaggtgagg  ccaccccca  agcagacct  2580
aagtagaaa  tgcccaatt  ttaccagct  gagggacac  cttgggttt  tgtacgaag  2640
tatttaatg  gcctgtgtc  tggggactc  gcaggctgg  gcttggggc  tggtggacc  2700
tcacctggt  tctgtaggt  gacccggtc  cccacaggt  acatcaacc  gagggtggc  2760
tctttagag  caggcacat  ggcagctct  ttcccttcg  ctctactgc  aggcctggg  2820
agatgttgt  ttcatgctg  ttccaccat  acactgggg  ttctggatg  gaaataaaa  2880
aataaaggc  gttcatttc  ccaaaaaaa  2909



<210> 431
<211> 456
<212> PRT
<213> Homo sapiens
<308> Q9NP24
<400> 431

Met Val Val Leu Asn Pro Met Thr Leu Gly Ile Tyr Leu Gln Leu Phe 
  1               5                  10                  15
Phe Leu Ser Ile Val Ser Gln Pro Thr Phe Ile Asn Ser Val Leu Pro 
             20                  25                  30
Ile Ser Ala Ala Leu Pro Ser Leu Asp Gln Lys Lys Arg Gly Gly His 
         35                  40                  45
Lys Ala Cys Cys Leu Leu Thr Pro Pro Pro Pro Pro Leu Phe Pro Pro 
     50                  55                  60
Pro Phe Phe Arg Gly Gly Arg Ser Pro Leu Leu Ser Pro Asp Met Lys 
 65                  70                  75                  80
Asn Leu Met Leu Glu Leu Glu Thr Ser Gln Ser Pro Cys Met Gln Gly 
                 85                  90                  95
Ser Leu Gly Ser Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Leu 
             100                105                110
Pro Gly Lys Thr Gly Pro Lys Gly Glu Lys Gly Glu Leu Gly Arg Pro 
         115                120                125
Gly Arg Lys Gly Arg Pro Gly Pro Pro Gly Val Pro Gly Met Pro Gly 
     130                135                140
Pro Ile Gly Trp Pro Gly Pro Glu Gly Pro Arg Gly Glu Lys Gly Asp 
 145                150                155                160
Leu Gly Met Met Gly Leu Pro Gly Ser Arg Gly Pro Met Gly Ser Lys 
                 165                170                175
Gly Tyr Pro Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Glu Lys Gly 
             180                185                190
Asp Leu Gly Pro Lys Gly Glu Lys Gly Phe Pro Gly Phe Pro Gly Met 
         195                200                205
Leu Gly Gln Lys Gly Glu Met Gly Pro Lys Gly Glu Pro Gly Ile Ala 
     210                215                220
Gly His Arg Gly Pro Thr Gly Arg Pro Gly Lys Arg Gly Lys Gln Gly 
 225                230                235                240
Gln Lys Gly Asp Ser Gly Val Met Gly Pro Pro Gly Lys Pro Gly Pro 
                 245                250                255
Ser Gly Gln Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Pro Ala Gly 
             260                265                270
Gln Leu Ile Met Gly Pro Lys Gly Glu Arg Gly Phe Pro Gly Pro Pro 
         275                280                285
Gly Arg Cys Leu Cys Gly Pro Thr Met Asn Val Asn Asn Pro Ser Tyr 
     290                295                300
Gly Glu Ser Val Tyr Gly Pro Ser Ser Pro Arg Val Pro Val Ile Phe 
 305                310                315                320
Val Val Asn Asn Gln Glu Glu Leu Glu Arg Leu Asn Thr Gln Asn Ala 
                 325                330                335
Ile Ala Phe Arg Arg Asp Gln Arg Ser Leu Tyr Phe Lys Asp Ser Leu 
             340                345                350
Gly Trp Leu Pro Ile Gln Leu Thr Pro Phe Tyr Pro Val Asp Tyr Thr 
         355                360                365
Ala Asp Gln His Gly Thr Cys Gly Asp Gly Leu Leu Gln Pro Gly Glu 
     370                375                380
Glu Cys Asp Asp Gly Asn Ser Asp Val Gly Asp Asp Cys Ile Arg Asp 
 385                390                395                400
Cys His Arg Ala Tyr Cys Gly Asp Gly His Arg His Glu Gly Val Glu 
                 405                410                415
Asp Cys Asp Gly Ser Asp Phe Gly Tyr Leu Thr Cys Glu Thr Tyr Leu 
             420                425                430
Pro Gly Ser Tyr Gly Asp Leu Gln Cys Thr Gln Tyr Cys Tyr Ile Asp 
         435                440                445
Ser Thr Pro Cys Arg Tyr Phe Thr 
     450                455



<210> 432
<211> 1018
<212> DNA
<213> Rattus norvegicus
<308> AF007758
<400> 432

gtgtggagc  aagatacat  tttagccat  gatgtgttc  tgaaaggac  ttcaaaggc  60
aaggaggga  ttgtggctg  tgctgagaa  accaagcag  gtgtggcag  ggcagctgg  120
aagacaaaa  agggcgtcc  ctatgtagg  tccaaaact  aggagggag  cgttcatgg  180
gtgacaaca  tggctgaga  gaccaaaga  caagtgaca  atgttggag  ggcagtggt  240
actggtgtg  cagcagtcg  tcagaagac  gtggaggga  ctgggaaca  tgctgctgc  300
actggtttt  tcaagaagg  ccagatggg  aagggtgaa  aagggtacc  acaagaggg  360
atcctggaa  acatgcctg  ggaccctag  agtgaggct  atgaaatgc  ttcagagga  420
ggctaccaa  actatgagc  tgaagccta  gaatgtcgt  gcacctact  tcctaagat  480
tgcccaggt  ttcttccat  gcgtacaag  gctcagttc  aacgtgccc  gtcatgacc  540
tttctcaaa  ctgtacagt  tatttcaaa  tcttccatc  gcagtgatc  gagtcctgt  600
cctgcccct  agcatcccg  tgctcccct  tcactacag  gaatacatg  tagcaggct  660
ttgtgtgct  tggatattg  tgtggcttc  aacctaaaa  gttagaaga  acttaaaac  720
cctaagtga  taccactta  ttccaactc  tcaccgttt  tggttgctg  tctcaagaa  780
ttgtgattt  ctataagac  tttagatgt  cttaatgat  ctttctgtc  aagaagaat  840
atgtgctgt  aaatttgtt  atatatatt  taaaatatg  gagcatgag  ctacgcacc  900
ataaatatt  atttatgaa  tttacagtt  tgtgacgtg  tttattaac  tgtgtttgt  960
tataaatgg  ggaaattaa  ataaaataa  aacattatc  cattgcaaa  aaaaaaaa  1018



<210> 433
<211> 140
<212> PRT
<213> Rattus norvegicus
<308> P37377
<400> 433

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
  1               5                  10                  15
Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
             20                  25                  30
Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
         35                  40                  45
Val His Gly Val Thr Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
     50                  55                  60
Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
 65                  70                  75                  80
Thr Val Glu Gly Ala Gly Asn Ile Ala Ala Ala Thr Gly Phe Val Lys 
                 85                  90                  95
Lys Asp Gln Met Gly Lys Gly Glu Glu Gly Tyr Pro Gln Glu Gly Ile 
             100                105                110
Leu Glu Asp Met Pro Val Asp Pro Ser Ser Glu Ala Tyr Glu Met Pro 
         115                120                125
Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
     130                135                140



<210> 434
<211> 411
<212> DNA
<213> Homo sapiens
<308> L36674
<400> 434

taaaggaat  cattagcca  ggatgtatt  atgaaagga  tttcaaagg  caaggaggg  60
gttgtggct  ctgctgaga  aaccaaaca  ggtgtggca  aagcagcag  aaagacaaa  120
gagggtgtt  tctatgtag  ggctgagaa  accaaagag  aagtgacaa  tgttggagg  180
gcagtggtg  cgggtgtga  agcagtagc  cagaagaca  tggagggag  agggagcat  240
gcagcagcc  ctggctttg  caaaaagga  cagttgggc  agaatgaag  aggagcccc  300
caggaagga  ttctggaag  tatgcctgt  gatcctgac  atgaggctt  tgaaatgcc  360
tctgaggaa  ggtatcaag  ctacgaacc  gaagcctaa  aaatatctt  g  411



<210> 435
<211> 140
<212> PRT
<213> Homo sapiens
<308> P37840
<400> 435

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
  1               5                  10                  15
Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
             20                  25                  30
Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
         35                  40                  45
Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
     50                  55                  60
Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
 65                  70                  75                  80
Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                 85                  90                  95
Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
             100                105                110
Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
         115                120                125
Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
     130                135                140



<210> 436
<211> 1018
<212> DNA
<213> Rattus norvegicus
<308> AF007758
<400> 436

gtgtggagc  aagatacat  tttagccat  gatgtgttc  tgaaaggac  ttcaaaggc  60
aaggaggga  ttgtggctg  tgctgagaa  accaagcag  gtgtggcag  ggcagctgg  120
aagacaaaa  agggcgtcc  ctatgtagg  tccaaaact  aggagggag  cgttcatgg  180
gtgacaaca  tggctgaga  gaccaaaga  caagtgaca  atgttggag  ggcagtggt  240
actggtgtg  cagcagtcg  tcagaagac  gtggaggga  ctgggaaca  tgctgctgc  300
actggtttt  tcaagaagg  ccagatggg  aagggtgaa  aagggtacc  acaagaggg  360
atcctggaa  acatgcctg  ggaccctag  agtgaggct  atgaaatgc  ttcagagga  420
ggctaccaa  actatgagc  tgaagccta  gaatgtcgt  gcacctact  tcctaagat  480
tgcccaggt  ttcttccat  gcgtacaag  gctcagttc  aacgtgccc  gtcatgacc  540
tttctcaaa  ctgtacagt  tatttcaaa  tcttccatc  gcagtgatc  gagtcctgt  600
cctgcccct  agcatcccg  tgctcccct  tcactacag  gaatacatg  tagcaggct  660
ttgtgtgct  tggatattg  tgtggcttc  aacctaaaa  gttagaaga  acttaaaac  720
cctaagtga  taccactta  ttccaactc  tcaccgttt  tggttgctg  tctcaagaa  780
ttgtgattt  ctataagac  tttagatgt  cttaatgat  ctttctgtc  aagaagaat  840
atgtgctgt  aaatttgtt  atatatatt  taaaatatg  gagcatgag  ctacgcacc  900
ataaatatt  atttatgaa  tttacagtt  tgtgacgtg  tttattaac  tgtgtttgt  960
tataaatgg  ggaaattaa  ataaaataa  aacattatc  cattgcaaa  aaaaaaaa  1018



<210> 437
<211> 140
<212> PRT
<213> Rattus norvegicus
<308> P37377
<400> 437

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
  1               5                  10                  15
Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
             20                  25                  30
Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
         35                  40                  45
Val His Gly Val Thr Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
     50                  55                  60
Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
 65                  70                  75                  80
Thr Val Glu Gly Ala Gly Asn Ile Ala Ala Ala Thr Gly Phe Val Lys 
                 85                  90                  95
Lys Asp Gln Met Gly Lys Gly Glu Glu Gly Tyr Pro Gln Glu Gly Ile 
             100                105                110
Leu Glu Asp Met Pro Val Asp Pro Ser Ser Glu Ala Tyr Glu Met Pro 
         115                120                125
Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
     130                135                140



<210> 438
<211> 411
<212> DNA
<213> Homo sapiens
<308> L36674
<400> 438

taaaggaat  cattagcca  ggatgtatt  atgaaagga  tttcaaagg  caaggaggg  60
gttgtggct  ctgctgaga  aaccaaaca  ggtgtggca  aagcagcag  aaagacaaa  120
gagggtgtt  tctatgtag  ggctgagaa  accaaagag  aagtgacaa  tgttggagg  180
gcagtggtg  cgggtgtga  agcagtagc  cagaagaca  tggagggag  agggagcat  240
gcagcagcc  ctggctttg  caaaaagga  cagttgggc  agaatgaag  aggagcccc  300
caggaagga  ttctggaag  tatgcctgt  gatcctgac  atgaggctt  tgaaatgcc  360
tctgaggaa  ggtatcaag  ctacgaacc  gaagcctaa  aaatatctt  g  411



<210> 439
<211> 140
<212> PRT
<213> Homo sapiens
<308> P37840
<400> 439

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
  1               5                  10                  15
Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
             20                  25                  30
Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
         35                  40                  45
Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
     50                  55                  60
Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
 65                  70                  75                  80
Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                 85                  90                  95
Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
             100                105                110
Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
         115                120                125
Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
     130                135                140



<210> 440
<211> 5655
<212> DNA
<213> Rattus norvegicus
<308> AF007836
<400> 440

cgggcggcc  cggcccggc  ccgcccccg  cccgccagc  cagcccgcg  ccggccgcg  60
tccggagct  agcgccagc  ctcgccccc  cgccgtgcc  ccgcctgcc  gcccccgcc  120
gccaaggct  ggctgcggg  ggccgccgg  cggccccga  cctcgccag  gcgacccaa  180
caaaggcag  atccgggct  ggcgggagg  agagcatca  gagagactg  gtcctcgct  240
tccccggct  cgctgctgc  gccgctgcc  ccgccgccg  cgccgccgc  gccgctgcc  300
ccgccagga  ggcttcgct  tgagcgttg  aaagcaggg  cgcagctgc  gggcgtgaa  360
ccgaaaggt  agagccaga  ccagcgagc  gagggggcg  gcaggccac  aaaaatgtc  420
tcggccgtg  ggccccgag  tcctcgccc  cccacggtg  ctcccccta  gcaagaact  480
cccgacctg  gccacctga  cgaggagga  aggaacatt  tcatggcag  gatggaccg  540
cagaaggaa  aggaggaaa  agaagaggc  atgctcaag  gtgttgtca  ggacatggc  600
aagcctgct  cctgcaaaa  accaagaaa  gctgaaagc  agccccatc  accaccact  660
aacattttc  gatgtgtct  tgttcccag  aagccaagc  gcgaagagg  aggcccaga  720
agagactgg  gattgcatc  acagtttga  agctacaag  agcaagtga  aaaaatcgg  780
gaggaagcg  ggcgttacc  gggcgagca  aaggatgat  ccccgacgt  tggaatctg  840
cataagaca  agtttgctg  tggatgtgg  catctctgc  cctattgtc  caccaagtt  900
tgtgcacgc  gcggaggcc  tgtgtctct  cgatcgaac  atgaggaca  agtggttat  960
tgggtatgc  atttatgtc  aaagcaaca  gaaatctta  cgaaatctg  agcgtggtt  1020
tttggaagt  gccctcagc  gcctagtca  gatgggact  tgagtgaca  ggccacagg  1080
gctggatct  aggtgccaa  agaaaagaa  gcaaggctc  aagagcgat  aaggtctca  1140
acgcccttg  gtacagcag  tgtctcttc  caagacact  ctacccccg  tgcaccgtt  1200
cacaggaac  aaggggctg  gccctcaca  caagccttg  gtcctgaac  gaagcaggc  1260
tcaagatca  gaagcgagc  accgaggga  aggaagaag  ctccagggc  ttcagagca  1320
aatggcaag  gaggccaga  gagcgagcg  aaacgtgtc  ccaagtctg  ggtgcaacc  1380
ggggaaggg  tcgcggatg  gagggagag  aaagagagg  gggaaaccc  caggttgga  1440
aaagggcgc  cccaggact  ctcagaccg  cctgagaaa  gcgacaatg  cagggtggc  1500
gaagaccag  agcagagga  ggaggagga  taccagact  ggtaccgca  cgaccctaa  1560
ctggctcgc  acccggtga  ggcgccgcc  gaggagcag  agatgcgca  gcacgcccg  1620
gtgtcccga  cgaggcacg  gcggcgcca  agcgacgtg  cgctcccgc  caccgaggc  1680
gctgccgcc  cgccggctg  ggccacggc  ggcaagcgc  cgccggcca  cgccagggt  1740
tctcccccg  agtccccgc  cgcacgcgc  gcggccgcc  agcctccca  cgagcacgg  1800
ccaccgccg  cgcggccag  cccgggtcc  gcagagcca  ccgagccgc  cgtccccga  1860
ccgctccgt  agcagggcc  cctggaccc  ggctcggcc  tgcttctgc  caaggccaa  1920
cgcgagaag  cggagagca  gctgcggaa  gactcgctg  gctccgatc  gtccgagtc  1980
gtgcggcca  ccccgccca  gcctcaccg  cccaagcgg  gaggcaaga  acgtcagat  2040
tcggtgagc  gctcggagg  ggagggcgt  tccacaccg  agtacacga  ctgcgagga  2100
gtggagctg  agagcgaga  cgtgagcga  aaaggtgac  tggattact  ctggttgga  2160
cccgccacg  ggcacagca  ggaaacgtc  cctatcagt  cgcatcctg  aacgtggca  2220
ccgtctaaa  agggagatc  actaatcgg  cgtgttatt  ttaacaaaa  aacaaccat  2280
cccaaagaa  caggtgcat  attgggtct  aaggtggtt  gaggaaaaa  gacggactt  2340
gggcgcctt  gtgctttca  caccaaagt  aagaagggc  gcctggcag  cgtcgtcgg  2400
cacctaaga  caggggacg  agtcctaga  tggaatggt  aacccctgc  gggagcaac  2460
aacgaagaa  tttacaaca  tatcttaga  tcaaaatca  aacctcaag  tgagattat  2520
gtttcaagg  ctattggtg  catccccag  atccctgag  gttcccatc  tcccctgga  2580
tccagttca  gttcctttg  atctcagaa  atggaaagg  cttctattt  tgttatttc  2640
ccaaccagc  ctggagctc  gaaagatgc  ccacaagtc  taccagggc  actctcagt  2700
aagctatgg  atgataaag  ggggcacca  ctgattgta  atgttctac  agcaacaga  2760
ctaccccct  gagtagatg  ccgtcccag  aatccctat  taaaaatgt  ttttcttcc  2820
gatagaagc  acaaaagta  aaggagaac  aaaacagta  agaaacttc  agagccaaa  2880
tggaaccag  catttgtct  ctcacacgt  catcgtaga  attttcgag  gcgaatgtt  2940
gagattacc  tgtgggacc  gccgagagt  caggacgaa  agagtgaat  tcttggaga  3000
atcctcata  agttggaaa  agcgctttt  gatgatgag  cccattggt  taaactcca  3060
acacatgac  aatcttcac  acctctgcc  cagccatca  cgttcatgc  caggcggca  3120
attcatgga  agagctcca  caaaaagct  caaagatct  agcgaatca  tgatagtga  3180
atctcagat  atgaggttg  tgatggtat  ggagtagtg  ctccagtgg  ttatagagc  3240
agtgctaga  agagtaaag  aaccacgtt  acagtgcca  agcaacaaa  aactacaca  3300
caccgctca  gttccgtgt  tcctcatcg  ggcgatgat  agggaaggc  tcgttcacg  3360
ttaccaaat  tgccattac  gaggagctt  gatgaaatt  atccaacac  aaggtcacg  3420
tctccaacc  gacaccatg  tgcctcccg  agcccggcc  atcacagat  cagacatgt  3480
gaaagtcaa  attcgtcag  gccagacag  gagcttctc  tgctgccca  agcaaaacg  3540
ggacgaagt  cagaaagcc  acacatgac  agtgaactg  agccctctc  tgacagggc  3600
aggagtgct  gtaccaact  cttgagacc  gatactagt  tgcattcac  agaacgaga  3660
aggcactcc  gaaagtctg  aagatgtag  atccaaaaa  agtctagga  aggcacagc  3720
tctgatgca  acagaacgc  ccgacaagg  agcccaacc  agtctcctc  agcagacac  3780
tccttcggc  gtcgccgtg  aagacagct  ccacaggtg  cagttcgaa  cggcagtat  3840
gaacaagca  gcttagtag  ggaggagcg  acgagacag  tgaaagtga  agttcaccg  3900
tttaagcag  caacagggt  tgggtctag  caagaactt  accacgagc  atactccaa  3960
tacaacata  ataaagatc  gtacagaag  tgtgataac  cgtctgcca  gtcttcaga  4020
agtgatgtc  gtgatgtgt  cgccatttc  agagccagc  gtacctcac  cctcagcag  4080
acaagcttt  tgtcagagc  gtctgagcg  cccaggggt  ggatcagtt  atttacccc  4140
aaaatgcaa  gcagacgga  ggggacttc  ggaagagcc  tcatcaaga  caccagtgt  4200
agtggagag  tatatacac  ggaacgtaa  gacggtagc  agtcggaca  ggccgtagg  4260
accgtcgga  ccggtggaa  gaaacgaag  tccagcctg  gcgccaaag  ggtagccat  4320
gtgtctcga  gaagcagga  cacgtcaca  ctcagccag  cagagtcgg  ccacaagaa  4380
ttgaaaagc  ccatccaga  gagtacgga  acaggaatg  cagctgaaa  gcggaagat  4440
gtgagacag  cgagccggg  gtccacgga  ggcagcatc  acagttata  ctcggaagg  4500
aacttgata  ttcctggag  tcgagtagg  cccgacagt  agttcagtg  tttccttga  4560
gggttggga  cagcgcagc  cgttggccg  cagacgctc  ccaccccgg  catgggcga  4620
atccaaatc  ggatggagg  taagaaggg  cagttggag  ttgaggtta  cagagcccg  4680
agccttaca  aaaaacctg  ttccaaatc  acacccgct  cctatgtga  agtatatct  4740
ttggaaaat  gagcctgta  tgccaaaaa  aagacaaga  ttgcacgga  aactctcga  4800
cctttgtat  agcagtccc  ggtttttga  gaaagtcca  agggtaaag  tcttcaggt  4860
attgtctgg  gtgactatg  aagaatgga  cacaaatgc  ttatgggtg  ggctcaaat  4920
ttgttggaa  aacttgatc  atccagcat  gtgattgga  ggtataaat  gttccctcc  4980
tcctcactg  tggatccca  tctcgctcc  ctgacccgc  gggcttccc  atcatctct  5040
gaaagttcg  ccgggcctc  ctgcatccg  tcatagtaa  ctcctatcc  tccagccaa  5100
ctctacatt  caggataat  atcagaacc  gattatttc  tgatcaaga  cattgttgg  5160
gacagacaa  caacttgtg  tttgcctgt  gtagttttt  gataatatg  cccaattgt  5220
gtttaaaat  tggcttcat  tgacagaac  aagcaagtc  gtcaaaatt  cagtaagaa  5280
ggacatgct  gtgagagcc  cttcacact  cttgcaaat  ggaaaaaca  aagaggaaa  5340
ctcaaattc  cacacacac  cacatacac  ccaaattga  caaactgga  attctcact  5400
tgtgaaaag  tgtacttca  atgtttctg  acagaccac  agcagtgtt  tttccctag  5460
gtttgagat  cttcagttc  gtgtgcttt  gttgtttgt  tgctgtttg  tgattcttt  5520
tgccccgtt  cctctcttt  tctgtcttc  ttgtattta  tatttccgc  agctttttt  5580
ttttcattt  tttttgtct  tgtctttct  tgctttgcc  tgacaggat  aggtggtgt  5640
aacagagac  gcttc  5655



<210> 441
<211> 1553
<212> PRT
<213> Rattus norvegicus
<308> AAB66703
<400> 441

Met Ser Ser Ala Val Gly Pro Arg Gly Pro Arg Pro Pro Thr Val Pro 
  1               5                  10                  15
Pro Pro Met Gln Glu Leu Pro Asp Leu Ser His Leu Thr Glu Glu Glu 
             20                  25                  30
Arg Asn Ile Ile Met Ala Val Met Asp Arg Gln Lys Glu Glu Glu Glu 
         35                  40                  45
Lys Glu Glu Ala Met Leu Lys Cys Val Val Arg Asp Met Ala Lys Pro 
     50                  55                  60
Ala Ala Cys Lys Thr Pro Arg Asn Ala Glu Ser Gln Pro His Gln Pro 
 65                  70                  75                  80
Pro Leu Asn Ile Phe Arg Cys Val Cys Val Pro Arg Lys Pro Ser Ser 
                 85                  90                  95
Glu Glu Gly Gly Pro Glu Arg Asp Trp Arg Leu His Gln Gln Phe Glu 
             100                105                110
Ser Tyr Lys Glu Gln Val Arg Lys Ile Gly Glu Glu Ala Arg Arg Tyr 
         115                120                125
Gln Gly Glu His Lys Asp Asp Ala Pro Thr Cys Gly Ile Cys His Lys 
     130                135                140
Thr Lys Phe Ala Asp Gly Cys Gly His Leu Cys Ser Tyr Cys Arg Thr 
 145                150                155                160
Lys Phe Cys Ala Arg Cys Gly Gly Arg Val Ser Leu Arg Ser Asn Asn 
                 165                170                175
Glu Asp Lys Val Val Met Trp Val Cys Asn Leu Cys Arg Lys Gln Gln 
             180                185                190
Glu Ile Leu Thr Lys Ser Gly Ala Trp Phe Phe Gly Ser Gly Pro Gln 
         195                200                205
Gln Pro Ser Gln Asp Gly Thr Leu Ser Asp Thr Ala Thr Gly Ala Gly 
     210                215                220
Ser Glu Val Pro Arg Glu Lys Lys Ala Arg Leu Gln Glu Arg Ser Arg 
 225                230                235                240
Ser Gln Thr Pro Leu Ser Thr Ala Ala Val Ser Ser Gln Asp Thr Ala 
                 245                250                255
Thr Pro Gly Ala Pro Leu His Arg Asn Lys Gly Ala Glu Pro Ser Gln 
             260                265                270
Gln Ala Leu Gly Pro Glu Gln Lys Gln Ala Ser Arg Ser Arg Ser Glu 
         275                280                285
Pro Pro Arg Glu Arg Lys Lys Ala Pro Gly Leu Ser Glu Gln Asn Gly 
     290                295                300
Lys Gly Gly Gln Lys Ser Glu Arg Lys Arg Val Pro Lys Ser Val Val 
 305                310                315                320
Gln Pro Gly Glu Gly Ile Ala Asp Glu Arg Glu Arg Lys Glu Arg Arg 
                 325                330                335
Glu Thr Arg Arg Leu Glu Lys Gly Arg Ser Gln Asp Tyr Ser Asp Arg 
             340                345                350
Pro Glu Lys Arg Asp Asn Gly Arg Val Ala Glu Asp Gln Lys Gln Arg 
         355                360                365
Lys Glu Glu Glu Tyr Gln Thr Arg Tyr Arg Ser Asp Pro Asn Leu Ala 
     370                375                380
Arg Tyr Pro Val Lys Ala Pro Pro Glu Glu Gln Gln Met Arg Met His 
 385                390                395                400
Ala Arg Val Ser Arg Ala Arg His Glu Arg Arg His Ser Asp Val Ala 
                 405                410                415
Leu Pro His Thr Glu Ala Ala Ala Ala Ala Pro Ala Glu Ala Thr Ala 
             420                425                430
Gly Lys Arg Ala Pro Ala Thr Ala Arg Val Ser Pro Pro Glu Ser Pro 
         435                440                445
Arg Ala Arg Ala Ala Ala Ala Gln Pro Pro Thr Glu His Gly Pro Pro 
     450                455                460
Pro Pro Arg Pro Ala Pro Gly Pro Ala Glu Pro Pro Glu Pro Arg Val 
 465                470                475                480
Pro Glu Pro Leu Arg Lys Gln Gly Arg Leu Asp Pro Gly Ser Ala Val 
                 485                490                495
Leu Leu Arg Lys Ala Lys Arg Glu Lys Ala Glu Ser Met Leu Arg Asn 
             500                505                510
Asp Ser Leu Ser Ser Asp Gln Ser Glu Ser Val Arg Pro Ser Pro Pro 
         515                520                525
Lys Pro His Arg Pro Lys Arg Gly Gly Lys Arg Arg Gln Met Ser Val 
     530                535                540
Ser Ser Ser Glu Glu Glu Gly Val Ser Thr Pro Glu Tyr Thr Ser Cys 
 545                550                555                560
Glu Asp Val Glu Leu Glu Ser Glu Ser Val Ser Glu Lys Gly Asp Leu 
                 565                570                575
Asp Tyr Tyr Trp Leu Asp Pro Ala Thr Trp His Ser Arg Glu Thr Ser 
             580                585                590
Pro Ile Ser Ser His Pro Val Thr Trp Gln Pro Ser Lys Glu Gly Asp 
         595                600                605
Arg Leu Ile Gly Arg Val Ile Leu Asn Lys Arg Thr Thr Met Pro Lys 
     610                615                620
Glu Ser Gly Ala Leu Leu Gly Leu Lys Val Val Gly Gly Lys Met Thr 
 625                630                635                640
Asp Leu Gly Arg Leu Gly Ala Phe Ile Thr Lys Val Lys Lys Gly Ser 
                 645                650                655
Leu Ala Asp Val Val Gly His Leu Arg Ala Gly Asp Glu Val Leu Glu 
             660                665                670
Trp Asn Gly Lys Pro Leu Pro Gly Ala Thr Asn Glu Glu Val Tyr Asn 
         675                680                685
Ile Ile Leu Glu Ser Lys Ser Glu Pro Gln Val Glu Ile Ile Val Ser 
     690                695                700
Arg Pro Ile Gly Asp Ile Pro Arg Ile Pro Glu Ser Ser His Pro Pro 
 705                710                715                720
Leu Glu Ser Ser Ser Ser Ser Phe Glu Ser Gln Lys Met Glu Arg Pro 
                 725                730                735
Ser Ile Ser Val Ile Ser Pro Thr Ser Pro Gly Ala Leu Lys Asp Ala 
             740                745                750
Pro Gln Val Leu Pro Gly Gln Leu Ser Val Lys Leu Trp Tyr Asp Lys 
         755                760                765
Val Gly His Gln Leu Ile Val Asn Val Leu Gln Ala Thr Asp Leu Pro 
     770                775                780
Pro Arg Val Asp Gly Arg Pro Arg Asn Pro Tyr Val Lys Met Tyr Phe 
 785                790                795                800
Leu Pro Asp Arg Ser Asp Lys Ser Lys Arg Arg Thr Lys Thr Val Lys 
                 805                810                815
Lys Leu Leu Glu Pro Lys Trp Asn Gln Thr Phe Val Tyr Ser His Val 
             820                825                830
His Arg Arg Asp Phe Arg Glu Arg Met Leu Glu Ile Thr Val Trp Asp 
         835                840                845
Gln Pro Arg Val Gln Asp Glu Glu Ser Glu Phe Leu Gly Glu Ile Leu 
     850                855                860
Ile Glu Leu Glu Thr Ala Leu Leu Asp Asp Glu Pro His Trp Tyr Lys 
 865                870                875                880
Leu Gln Thr His Asp Glu Ser Ser Leu Pro Leu Pro Gln Pro Ser Pro 
                 885                890                895
Phe Met Pro Arg Arg His Ile His Gly Glu Ser Ser Ser Lys Lys Leu 
             900                905                910
Gln Arg Ser Gln Arg Ile Ser Asp Ser Asp Ile Ser Asp Tyr Glu Val 
         915                920                925
Asp Asp Gly Ile Gly Val Val Pro Pro Val Gly Tyr Arg Ala Ser Ala 
     930                935                940
Arg Glu Ser Lys Ala Thr Thr Leu Thr Val Pro Glu Gln Gln Arg Thr 
 945                950                955                960
Thr His His Arg Ser Arg Ser Val Ser Pro His Arg Gly Asp Asp Gln 
                 965                970                975
Gly Arg Pro Arg Ser Arg Leu Pro Asn Val Pro Leu Gln Arg Ser Leu 
             980                985                990
Asp Glu Ile His Pro Thr Arg Arg Ser Arg Ser Pro Thr Arg His His 
         995                1000                1005
Asp Ala Ser Arg Ser Pro Ala Asp His Arg Ser Arg His Val Glu Ser 
     1010                1015                1020
Gln Tyr Ser Ser Glu Pro Asp Ser Glu Leu Leu Met Leu Pro Arg Ala 
 1025                1030                1035                1040
Lys Arg Gly Arg Ser Ala Glu Ser Leu His Met Thr Ser Glu Leu Gln 
                 1045                1050                1055
Pro Ser Leu Asp Arg Ala Arg Ser Ala Ser Thr Asn Cys Leu Arg Pro 
             1060                1065                1070
Asp Thr Ser Leu His Ser Pro Glu Arg Glu Arg His Ser Arg Lys Ser 
         1075                1080                1085
Glu Arg Cys Ser Ile Gln Lys Gln Ser Arg Lys Gly Thr Ala Ser Asp 
     1090                1095                1100
Ala Asp Arg Thr His Arg Gln Gly Ser Pro Thr Gln Ser Pro Pro Ala 
 1105                1110                1115                1120
Asp Thr Ser Phe Gly Ser Arg Arg Gly Arg Gln Leu Pro Gln Val Pro 
                 1125                1130                1135
Val Arg Ser Gly Ser Ile Glu Gln Ala Ser Leu Val Val Glu Glu Arg 
             1140                1145                1150
Thr Arg Gln Met Lys Val Lys Val His Arg Phe Lys Gln Thr Thr Gly 
         1155                1160                1165
Ser Gly Ser Ser Gln Glu Leu Asp His Glu Gln Tyr Ser Lys Tyr Asn 
     1170                1175                1180
Ile His Lys Asp Gln Tyr Arg Ser Cys Asp Asn Ala Ser Ala Lys Ser 
 1185                1190                1195                1200
Ser Asp Ser Asp Val Ser Asp Val Ser Ala Ile Ser Arg Ala Ser Ser 
                 1205                1210                1215
Thr Ser Arg Leu Ser Ser Thr Ser Phe Met Ser Glu Gln Ser Glu Arg 
             1220                1225                1230
Pro Arg Gly Arg Ile Ser Ser Phe Thr Pro Lys Met Gln Gly Arg Arg 
         1235                1240                1245
Met Gly Thr Ser Gly Arg Ala Ile Ile Lys Ser Thr Ser Val Ser Gly 
     1250                1255                1260
Glu Ile Tyr Thr Leu Glu Arg Asn Asp Gly Ser Gln Ser Asp Thr Ala 
 1265                1270                1275                1280
Val Gly Thr Val Gly Ala Gly Gly Lys Lys Arg Arg Ser Ser Leu Ser 
                 1285                1290                1295
Ala Lys Val Val Ala Ile Val Ser Arg Arg Ser Arg Ser Thr Ser Gln 
             1300                1305                1310
Leu Ser Gln Thr Glu Ser Gly His Lys Lys Leu Lys Ser Thr Ile Gln 
         1315                1320                1325
Arg Ser Thr Glu Thr Gly Met Ala Ala Glu Met Arg Lys Met Val Arg 
     1330                1335                1340
Gln Pro Ser Arg Glu Ser Thr Asp Gly Ser Ile Asn Ser Tyr Ser Ser 
 1345                1350                1355                1360
Glu Gly Asn Leu Ile Phe Pro Gly Val Arg Val Gly Pro Asp Ser Gln 
                 1365                1370                1375
Phe Ser Asp Phe Leu Asp Gly Leu Gly Pro Ala Gln Leu Val Gly Arg 
             1380                1385                1390
Gln Thr Leu Ala Thr Pro Ala Met Gly Asp Ile Gln Ile Gly Met Glu 
         1395                1400                1405
Asp Lys Lys Gly Gln Leu Glu Val Glu Val Ile Arg Ala Arg Ser Leu 
     1410                1415                1420
Thr Gln Lys Pro Gly Ser Lys Ser Thr Pro Ala Pro Tyr Val Lys Val 
 1425                1430                1435                1440
Tyr Leu Leu Glu Asn Gly Ala Cys Ile Ala Lys Lys Lys Thr Arg Ile 
                 1445                1450                1455
Ala Arg Lys Thr Leu Asp Pro Leu Tyr Gln Gln Ser Leu Val Phe Asp 
             1460                1465                1470
Glu Ser Pro Gln Gly Lys Val Leu Gln Val Ile Val Trp Gly Asp Tyr 
         1475                1480                1485
Gly Arg Met Asp His Lys Cys Phe Met Gly Val Ala Gln Ile Leu Leu 
     1490                1495                1500
Glu Glu Leu Asp Leu Ser Ser Met Val Ile Gly Trp Tyr Lys Leu Phe 
 1505                1510                1515                1520
Pro Pro Ser Ser Leu Val Asp Pro Thr Leu Ala Pro Leu Thr Arg Arg 
                 1525                1530                1535
Ala Ser Gln Ser Ser Leu Glu Ser Ser Ser Gly Pro Pro Cys Ile Arg 
             1540                1545                1550
Ser 
         1555



<210> 442
<211> 6395
<212> DNA
<213> Homo sapiens
<308> AB002338
<400> 442

caggggcgc  gctgctggg  gtgcatccg  aaggtgaga  ccagagagc  agcagaggg  60
gcgggcagg  cacgaaaat  tcctcggcc  tggggcccc  cggtcctcg  ccacccacg  120
tgcctcccc  catgcaaga  ctgcccgac  tgagccacc  gaccgaaga  gagaggaac  180
ttatcatgg  agtgatgga  cggcagaag  aagaggagg  aaaagaaga  gccatgctc  240
agtgtgttg  cagggacat  gcgaagcct  ctgcctgca  aacaccaag  aatgctgaa  300
accagcccc  ccaaccttc  ccgagattg  atcaacagt  tgaaagcta  aaggaacaa  360
tgagaaaaa  aggggaaga  gcgcggcgt  accagggcg  gcacaaaga  gatgctccg  420
cttgtggaa  ctgtcataa  acaaagttt  ctgatgggt  cggtcatct  tgctcctat  480
gtcgcacta  gttctgtgc  cgctgcgga  gccgcgtgt  tctacggtc  aacaacgag  540
acaaagtgg  tatgtgggt  tgcaattta  gtcgaaagc  acaagaaat  ttaaccaaa  600
ctggggcat  gttctttgg  agtggccct  agcagacaa  tcaggatgg  accctgagt  660
atacagcta  aggtgctgg  tctgaggta  caagagaaa  gaaagcacg  ctccaagag  720
gatcgcggt  tcagacacc  ctgagcaca  cagctgcct  ctcccagga  gctgctcct  780
ccagcgcac  accagacag  agcaaaggg  ctgagccct  gcagcaagc  ttggggcct  840
aacagaagc  ggcttcatc  aggtctaga  gtgaacctc  tagagagag  aagaagacc  900
cagggcttt  cgagcagaa  ggcaaagga  ccctgaaga  cgagcggaa  cgcgtgcca  960
agacctcag  gcagcccgt  gagggggcc  tcgaagaac  ggagcgcaa  gaaaggcgg  1020
aaagccgaa  gcttgagaa  gggcgatca  aggattacc  agacacgcc  gaaaaacgg  1080
atgagggca  agcggcgga  gaggaaaag  aaagaaaag  ggaggatta  cagaccagg  1140
accgcagcg  cccgaacct  gctcggtac  cggtgaaac  gccgcctga  gagcagcag  1200
tgcgcatgc  cgcccgggt  tcccgcgcc  ggcacgagc  gcgccacag  gacgtggcg  1260
tcccgcgca  cgaggcggg  gcggcgctg  cggagggca  ggccggcaa  cgcgcgccg  1320
cggcagcca  ggcctcgcc  ccggactcg  cgcgggctt  ctcggctga  agaactgcg  1380
agaccaggg  gccgggcgc  aagcagcta  cgaaccaca  cccgccggc  cccagacat  1440
ggccggttc  cgcagaagc  ccggagctc  aagcccagg  gcccctcag  aagcagagc  1500
gcctggacc  cagctcggc  gtcctcatg  tgcggaacg  ctctttgag  tcagaccag  1560
ccgagtcgg  gcggccgtc  ccgcccaag  cgcaccggt  caagagagg  ggcaagaag  1620
ggcagatgt  ggtgagcag  tctgaggag  agggcgtgt  gacgcccga  tacaccagc  1680
gcgaggacg  ggagctgga  agcgagagc  tcagcgaga  aggtgattt  gattattac  1740
ggttggatc  tgccacgtg  cacagccgg  agacatcac  tattagttc  catcctgta  1800
cgtggcaac  atctaaaga  ggggaccga  taattggac  tgttattct  aacaagaga  1860
caaccatgc  caaagactc  ggtgcattg  tgggtctga  agttgttgg  ggaaaaatg  1920
ctgacttag  acgacttgg  gctttcatc  ccaaagtaa  gaagggtag  ctagcagat  1980
tagttggac  cctaagagc  ggggatgaa  ttctagaat  gaatggtaa  cccctgccg  2040
gagctacaa  tgaagaagt  tacaacatt  ttttagaat  aaaatcaga  cctcaagtt  2100
aaattattg  ttcaaggcc  attggtgac  ttccccgga  tcctgagag  tcccaccct  2160
cactggagt  cagttcaag  tcctttgaa  ctcagaaga  ggaaaggcc  tccatttct  2220
ttatttctc  aacaagtcc  ggagctcta  aagatgccc  acaagtctt  ccagggcaa  2280
tttctgtga  gttgtggta  gataaagtg  gacaccagc  gattgtaaa  gttctgcaa  2340
caacagatc  acctgctag  gtagatgga  gtcctcgaa  tccctatgt  aaaatgtat  2400
ttcttccag  tagaagtga  aaaagtaaa  ggaggacca  aacagtaaa  aaaatacta  2460
aaccaaaat  gaatcaaac  tttgtctat  cacatgtac  tcgtagaga  tttagagaa  2520
gaatgttag  aataactgt  tgggaccaa  caagagtgc  agaagaaga  agtgaattt  2580
ttggagaga  cctcataga  ttggagaca  cgcttttag  tgatgaacc  cattggtat  2640
aacttcaga  acatgatga  tcttcacta  ctctgcctc  gccatcacc  ttcatgcca  2700
ggcgacata  tcatggaga  agctctagc  aaaagctac  aagatctca  cgaatcagt  2760
atagtgaca  ctcagatta  gaggttgat  atggtattg  cgtagttcc  ccagtaggc  2820
ataggtcta  tgctagaga  agtaaatct  caacattaa  tgtgccaga  cagcaaaga  2880
caactcatc  ccgctcacg  tcagtatct  ctcatcgcg  caatgatca  ggaaagccg  2940
gttcacgtt  accaaatgt  ccattacag  ggagtttag  tgaaattca  ccaacaaga  3000
ggtcacgtt  tccaaccag  caccatgat  cctcccgaa  tccagttga  catagaacc  3060
gagatgtgg  tagtcagta  ttatcagaa  aagacagtg  gcttcttat  ctgcccaga  3120
caaaacgag  acgaagtgc  gaatgccta  atactacca  gtaaataca  ggatttggt  3180
atggtgact  tgtgtgatg  ctctctttc  attctatta  tcttccgtc  ctcccttag  3240
ggtattatt  caagcaagt  aaataaatt  cccaagtat  tgaaatttg  tttgtttta  3300
attgaggtt  tggaaaagg  tccaaatat  tttcagttc  gattcaggc  gactgcttt  3360
ccatctgta  attcaaaaa  ccagagact  gtgggcctc  ctgggactg  ttgcgttcc  3420
aaaactgag  aaccagttt  tgcaattaa  attctaaat  ctcactgtg  gtgccccca  3480
ctttcccac  catattcct  tctagtcac  agaggtcta  tctgtgtat  gcagtgtca  3540
tgtttcata  ttgtaagtt  gctctgttt  agccttttt  aatttcctt  tagaattta  3600
tgttgttta  attctgttt  cttttgata  aatctttaa  agttcactt  taatggctg  3660
gcttcagct  ctttcttga  gaaaagtga  gatattcaa  ctgatctta  ctatcctag  3720
ccaccagtt  tcagaaatg  tgcagtaca  actttccca  aaaggcata  aacagtatg  3780
atgcctctt  agaagcgac  aaagatata  tttttgctt  taaattgga  cttagagcc  3840
gatgcttta  gttaatctc  ttacatctt  aatttcata  ccaagtaaa  cttcttaca  3900
attactcat  gaacatatt  tataaatac  taatgtata  ttgaaatga  tatagaagt  3960
aaggaagta  taagtcagt  aaacaaact  acacaaaat  atcgaactc  aatatttta  4020
ccaataaaa  gcaagagga  agagaaaga  agaggtatt  ccgcagtac  tgggatgca  4080
agacaaatg  atgatttat  atgtctgtg  gtaatatgt  gttctgccc  ataatgcaa  4140
caaaattgg  ctaataaaa  ttgtttgaa  tttttacag  ctgaagtta  actactcat  4200
actactgcc  tgtttgctt  gagtgccac  ggaaaaaat  gaggaaata  tagttctgc  4260
tgctgagaa  aaaatgtaa  atcatgcat  ttgtaaaaa  ctactgaag  tcaaagcat  4320
aactatcca  gtttattat  acttgttct  gacaaacag  ttcttaaaa  aatggttta  4380
ttactaatt  tgaaagttt  ctcacactc  tcttgatgt  actaaagct  caaaagaaa  4440
aaaaaacat  cacacaaaa  aaacacaaa  aaaatcctt  tattttaag  tacttagtg  4500
gtgcctggc  ctcagtgtg  gaatatttc  aggatactc  caccagtgg  ctaaatata  4560
taactaaaa  tatttttct  tcccttatt  tgtacttgt  aaatattat  tacttatat  4620
atattatat  atagttgca  cattttata  aatcttata  ttaagattg  tgctttgct  4680
ataattctg  gctccacaa  tcctattta  tagtctctg  atgttgact  tgcatttcc  4740
gatttaagc  aataatcat  tttgtatgt  tacaattta  aaataaatg  gtattcagc  4800
aggcagata  catcctgtg  acaggtact  cgacaataa  atagggagt  gaaggaagc  4860
gagctagcc  aatgtgtca  tgcgaaaca  atgtcacca  tgtcttttc  ccttcctgt  4920
tttcattct  taatgtgta  tgctaaaag  atggagata  agacaacat  agttcaaaa  4980
tacgtgcat  tatgtatat  taatctctt  tgtgtttat  ttcatgtat  tataaaaac  5040
ttaatttat  tctgtataa  aatgaatgt  aaaatgtgt  catataaat  accacaact  5100
tatatggat  tatcaataa  atagtttgg  ttcatataa  ctatggaca  ttattattt  5160
tataactat  catggctaa  atctaaagc  ttcaaaata  atcatacca  gttcactta  5220
gacttataa  aataaaatc  gaggattta  tagtctcta  taaacataa  gaaaataac  5280
tttatttaa  aacaagcac  gtgttaaat  tttaatgta  tttgtcaat  tcctgacaa  5340
aattatatg  tatgaatat  attatcctg  ttttagaga  gaggaaaaa  gctacgaaa  5400
tttatttta  gactaatag  gtaaggatt  aaaatcaga  ctatttgat  tcttctgtt  5460
aactagttt  tccaaaaat  tgaaaactt  tcctatgag  tgtttcacc  ataagagtt  5520
ttgtgagtc  aatacattt  ggaaacttt  caactgaaa  tgtctacct  gaaatttaa  5580
acacacagc  tattaaagt  atgttctaa  gaaatctgt  tgtttagtt  cttttctcc  5640
aaattgttt  atttcccaa  cttttttta  taaaacgtg  ctcgaggaa  tggtagtat  5700
gagaaaatg  tatagttgc  ttactgtat  ctactgtgt  ctaaatatt  tgtacatgt  5760
accacacac  cctgttaag  ggaagttat  tcccacatt  tgtggatgt  gaaacaggc  5820
tggagactt  atcgaatta  ccaggtcac  gccaataag  ggcaaagcc  aggcaggaa  5880
ttgaacatt  agactataa  ttttgtgct  ttttctagc  gtttcccat  ctatgttga  5940
cccattctt  aaaaaaaaa  cacttttga  gcaatgctt  gaaaagttt  atagcaacc  6000
attactaaa  atatttgcc  gaggttagg  gttgaaaag  agagtcgac  gtctagaaa  6060
gaggctaaa  ccttagttt  agtaaaatt  gtcctcaac  tgtacttaa  aaggaggaa  6120
ctgaagcgg  cagatcact  gaggtcagg  gtttgagac  agtgtggcc  acatggtga  6180
accccgtct  tactaaaac  cacacacac  cacacacac  cacacacac  cacacaaat  6240
aggtgggca  ggtggcagg  gcttgtaat  ccagctact  gggaggctg  gagaggaga  6300
ttgcttgaa  ccaggaggc  gaggttgca  tgagccaag  tcacaccat  gcactccag  6360
ctagataac  agagtgaga  tctgtctca  aaaag  6395



<210> 443
<211> 1053
<212> PRT
<213> Homo sapiens
<308> BAA20798
<400> 443

Gly Ala Gln Leu Leu Gly Val His Pro Lys Gly Glu Ser Gln Arg Ala 
  1               5                  10                  15
Ser Arg Gly Gly Gly Gln Ala Thr Lys Met Ser Ser Ala Val Gly Pro 
             20                  25                  30
Arg Gly Pro Arg Pro Pro Thr Val Pro Pro Pro Met Gln Glu Leu Pro 
         35                  40                  45
Asp Leu Ser His Leu Thr Glu Glu Glu Arg Asn Ile Ile Met Ala Val 
     50                  55                  60
Met Asp Arg Gln Lys Glu Glu Glu Glu Lys Glu Glu Ala Met Leu Lys 
 65                  70                  75                  80
Cys Val Val Arg Asp Met Ala Lys Pro Ala Ala Cys Lys Thr Pro Arg 
                 85                  90                  95
Asn Ala Glu Asn Gln Pro His Gln Pro Ser Pro Arg Leu His Gln Gln 
             100                105                110
Phe Glu Ser Tyr Lys Glu Gln Val Arg Lys Ile Gly Glu Glu Ala Arg 
         115                120                125
Arg Tyr Gln Gly Glu His Lys Asp Asp Ala Pro Thr Cys Gly Ile Cys 
     130                135                140
His Lys Thr Lys Phe Ala Asp Gly Cys Gly His Leu Cys Ser Tyr Cys 
 145                150                155                160
Arg Thr Lys Phe Cys Ala Arg Cys Gly Gly Arg Val Ser Leu Arg Ser 
                 165                170                175
Asn Asn Glu Asp Lys Val Val Met Trp Val Cys Asn Leu Cys Arg Lys 
             180                185                190
Gln Gln Glu Ile Leu Thr Lys Ser Gly Ala Trp Phe Phe Gly Ser Gly 
         195                200                205
Pro Gln Gln Thr Ser Gln Asp Gly Thr Leu Ser Asp Thr Ala Thr Gly 
     210                215                220
Ala Gly Ser Glu Val Pro Arg Glu Lys Lys Ala Arg Leu Gln Glu Arg 
 225                230                235                240
Ser Arg Ser Gln Thr Pro Leu Ser Thr Ala Ala Ala Ser Ser Gln Asp 
                 245                250                255
Ala Ala Pro Pro Ser Ala Pro Pro Asp Arg Ser Lys Gly Ala Glu Pro 
             260                265                270
Ser Gln Gln Ala Leu Gly Pro Glu Gln Lys Gln Ala Ser Ser Arg Ser 
         275                280                285
Arg Ser Glu Pro Pro Arg Glu Arg Lys Lys Thr Pro Gly Leu Ser Glu 
     290                295                300
Gln Asn Gly Lys Gly Ala Leu Lys Ser Glu Arg Lys Arg Val Pro Lys 
 305                310                315                320
Thr Ser Ala Gln Pro Val Glu Gly Ala Val Glu Glu Arg Glu Arg Lys 
                 325                330                335
Glu Arg Arg Glu Ser Arg Arg Leu Glu Lys Gly Arg Ser Gln Asp Tyr 
             340                345                350
Pro Asp Thr Pro Glu Lys Arg Asp Glu Gly Lys Ala Ala Asp Glu Glu 
         355                360                365
Lys Gln Arg Lys Glu Glu Asp Tyr Gln Thr Arg Tyr Arg Ser Asp Pro 
     370                375                380
Asn Leu Ala Arg Tyr Pro Val Lys Pro Pro Pro Glu Glu Gln Gln Met 
 385                390                395                400
Arg Met His Ala Arg Val Ser Arg Ala Arg His Glu Arg Arg His Ser 
                 405                410                415
Asp Val Ala Leu Pro Arg Thr Glu Ala Gly Ala Ala Leu Pro Glu Gly 
             420                425                430
Lys Ala Gly Lys Arg Ala Pro Ala Ala Ala Arg Ala Ser Pro Pro Asp 
         435                440                445
Ser Pro Arg Ala Tyr Ser Ala Glu Arg Thr Ala Glu Thr Arg Ala Pro 
     450                455                460
Gly Ala Lys Gln Leu Thr Asn His Ser Pro Pro Ala Pro Arg His Gly 
 465                470                475                480
Pro Val Pro Ala Glu Ala Pro Glu Leu Lys Ala Gln Glu Pro Leu Arg 
                 485                490                495
Lys Gln Ser Arg Leu Asp Pro Ser Ser Ala Val Leu Met Leu Arg Asn 
             500                505                510
Asp Ser Leu Ser Ser Asp Gln Ser Glu Ser Val Arg Pro Ser Pro Pro 
         515                520                525
Lys Pro His Arg Ser Lys Arg Gly Gly Lys Lys Arg Gln Met Ser Val 
     530                535                540
Ser Ser Ser Glu Glu Glu Gly Val Ser Thr Pro Glu Tyr Thr Ser Cys 
 545                550                555                560
Glu Asp Val Glu Leu Glu Ser Glu Ser Val Ser Glu Lys Gly Asp Leu 
                 565                570                575
Asp Tyr Tyr Trp Leu Asp Pro Ala Thr Trp His Ser Arg Glu Thr Ser 
             580                585                590
Pro Ile Ser Ser His Pro Val Thr Trp Gln Pro Ser Lys Glu Gly Asp 
         595                600                605
Arg Leu Ile Gly Arg Val Ile Leu Asn Lys Arg Thr Thr Met Pro Lys 
     610                615                620
Asp Ser Gly Ala Leu Leu Gly Leu Lys Val Val Gly Gly Lys Met Thr 
 625                630                635                640
Asp Leu Gly Arg Leu Gly Ala Phe Ile Thr Lys Val Lys Lys Gly Ser 
                 645                650                655
Leu Ala Asp Val Val Gly His Leu Arg Ala Gly Asp Glu Val Leu Glu 
             660                665                670
Trp Asn Gly Lys Pro Leu Pro Gly Ala Thr Asn Glu Glu Val Tyr Asn 
         675                680                685
Ile Ile Leu Glu Ser Lys Ser Glu Pro Gln Val Glu Ile Ile Val Ser 
     690                695                700
Arg Pro Ile Gly Asp Ile Pro Arg Ile Pro Glu Ser Ser His Pro Pro 
 705                710                715                720
Leu Glu Ser Ser Ser Ser Ser Phe Glu Ser Gln Lys Met Glu Arg Pro 
                 725                730                735
Ser Ile Ser Val Ile Ser Pro Thr Ser Pro Gly Ala Leu Lys Asp Ala 
             740                745                750
Pro Gln Val Leu Pro Gly Gln Leu Ser Val Lys Leu Trp Tyr Asp Lys 
         755                760                765
Val Gly His Gln Leu Ile Val Asn Val Leu Gln Ala Thr Asp Leu Pro 
     770                775                780
Ala Arg Val Asp Gly Arg Pro Arg Asn Pro Tyr Val Lys Met Tyr Phe 
 785                790                795                800
Leu Pro Asp Arg Ser Asp Lys Ser Lys Arg Arg Thr Lys Thr Val Lys 
                 805                810                815
Lys Ile Leu Glu Pro Lys Trp Asn Gln Thr Phe Val Tyr Ser His Val 
             820                825                830
His Arg Arg Asp Phe Arg Glu Arg Met Leu Glu Ile Thr Val Trp Asp 
         835                840                845
Gln Pro Arg Val Gln Glu Glu Glu Ser Glu Phe Leu Gly Glu Ile Leu 
     850                855                860
Ile Glu Leu Glu Thr Ala Leu Leu Asp Asp Glu Pro His Trp Tyr Lys 
 865                870                875                880
Leu Gln Thr His Asp Glu Ser Ser Leu Pro Leu Pro Gln Pro Ser Pro 
                 885                890                895
Phe Met Pro Arg Arg His Ile His Gly Glu Ser Ser Ser Lys Lys Leu 
             900                905                910
Gln Arg Ser Gln Arg Ile Ser Asp Ser Asp Ile Ser Asp Tyr Glu Val 
         915                920                925
Asp Asp Gly Ile Gly Val Val Pro Pro Val Gly Tyr Arg Ser Ser Ala 
     930                935                940
Arg Glu Ser Lys Ser Thr Thr Leu Thr Val Pro Glu Gln Gln Arg Thr 
 945                950                955                960
Thr His His Arg Ser Arg Ser Val Ser Pro His Arg Gly Asn Asp Gln 
                 965                970                975
Gly Lys Pro Arg Ser Arg Leu Pro Asn Val Pro Leu Gln Arg Ser Leu 
             980                985                990
Asp Glu Ile His Pro Thr Arg Arg Ser Arg Ser Pro Thr Arg His His 
         995                1000                1005
Asp Ala Ser Arg Ser Pro Val Asp His Arg Thr Arg Asp Val Asp Ser 
     1010                1015                1020
Gln Tyr Leu Ser Glu Gln Asp Ser Glu Leu Leu Met Leu Pro Arg Ala 
 1025                1030                1035                1040
Lys Arg Gly Arg Ser Ala Glu Cys Leu His Thr Thr Arg 
                 1045                1050



<210> 444
<211> 808
<212> DNA
<213> Rattus norvegicus
<308> AF007890
<400> 444

aactgaatg  ctgcccgtc  ccctgttgt  ggtggtaac  tcaagtgca  tggtgattt  60
gccttcatc  agactcaca  cgaggtctt  aagacgatc  caaagaaca  tgttgaagt  120
tacgttgct  cttctgcaa  ccacttgaa  actcttgcc  acaacctta  gggtactca  180
atcgaggtt  ctgctcaga  cgtttacta  gagaagcct  gcgcatgga  tggtgagtt  240
aacgttgaa  tgctgcttg  ttgcggcct  aagactgtc  tcattggtc  ctctgagag  300
cgtcgtatc  tgggtgaaa  taacgaaca  tctgctaaa  aggctgctc  tgctatctc  360
cttggcatg  ctgttgctt  ctgcattgg  gagactctt  aggaaagaa  cgctggcaa  420
gttgacgag  ttaacttcg  tcagctcga  gctcttcgt  ccgttctga  agaagctga  480
tggaagaac  tcatcattg  ttatgaacc  gtttggtct  tcggtactg  tgtcgttgc  540
tcacctgaa  aagctcagg  ggttcacgc  tccatcaga  agtggctcg  tgagaaggt  600
tccaaggct  ttgctgatg  cacccgtat  caatatggt  gttccgtca  cgctgctaa  660
tgcgccgct  ttggcaagt  cccagatat  gatggtttc  ttgttggtg  tgcttccct  720
aagccagag  tcgtccaga  cgtcactac  ctcggtgat  tcaagaaat  agcttgtaa  780
gttcaaaaa  aaaaaaaaa  aaaaaaaa  808



<210> 445
<211> 254
<212> PRT
<213> Rattus norvegicus
<308> AAC23442
<400> 445

Met Ser Ala Arg Arg Pro Val Val Gly Gly Asn Phe Lys Cys Asn Gly 
  1               5                  10                  15
Asp Phe Ala Phe Ile Lys Thr His Thr Glu Val Leu Lys Thr Ile Pro 
             20                  25                  30
Lys Asn Asn Val Glu Val Tyr Val Ala Pro Ser Ala Ile His Leu Lys 
         35                  40                  45
Thr Leu Ala Asp Asn Leu Lys Gly Thr His Ile Glu Val Ala Ala Gln 
     50                  55                  60
Asn Val Tyr Tyr Glu Lys Pro Gly Ala Trp Thr Gly Glu Leu Asn Val 
 65                  70                  75                  80
Glu Met Leu Leu Asp Cys Gly Leu Lys Thr Val Ile Ile Gly His Ser 
                 85                  90                  95
Glu Arg Arg Arg Ile Met Gly Glu Thr Asn Glu Gln Ser Ala Lys Lys 
             100                105                110
Ala Ala Arg Ala Ile Ser Leu Gly Met Thr Val Ala Phe Cys Ile Gly 
         115                120                125
Glu Thr Leu Glu Glu Arg Asn Ala Gly Lys Val Asp Glu Val Asn Phe 
     130                135                140
Ala Gln Leu Glu Ala Leu Arg Ala Val Leu Lys Glu Ala Asp Trp Lys 
 145                150                155                160
Asn Val Ile Ile Ala Tyr Glu Pro Val Trp Ser Ile Gly Thr Gly Val 
                 165                170                175
Val Ala Ser Pro Glu Gln Ala Gln Glu Val His Ala Ser Ile Arg Lys 
             180                185                190
Trp Leu Gly Glu Lys Val Ser Lys Ala Val Ala Asp Ala Thr Arg Ile 
         195                200                205
Gln Tyr Gly Gly Ser Val Asn Ala Ala Asn Cys Ala Ala Leu Gly Lys 
     210                215                220
Cys Pro Asp Ile Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys Pro 
 225                230                235                240
Glu Phe Val Gln Ile Val Thr Thr Leu Gly Asp Val Lys Lys 
                 245                250



<210> 446
<211> 1774
<212> DNA
<213> Homo sapiens
<308> NM_000365
<400> 446

ggcacgagg  agaactagt  tcagttttt  ttttttttt  tttaggtga  aaagccagc  60
gactttatt  ctctggggg  agggggctc  ggagctctt  gtggggcgg  tccgcttcc  120
cttcaccat  acaggcttc  ggctgcgca  gatggcgct  gccctgcgg  tggctgcca  180
gcgcaggtc  gggcggtac  tgttcttgc  gatcatgtg  ctgatgctg  tgagcgtgg  240
gcgagcatt  ttgttgatg  tggtccgca  ataggaggt  gcaggcttc  gctggccgg  300
tctccgctt  atgaccacc  cgacacctt  gccgtcggc  gccggctcc  cgcccacag  360
cttgcggtg  atcagtccg  tgtagcgga  ggaattgcg  gccttcaag  tattgggct  420
agtgctgta  gtctgctta  tcctcttga  caggaaact  gagcagttc  gcacgacca  480
ccattgcag  tgcgcagac  tggcggcgg  tcccttcgc  gcggcgacc  gaccttcag  540
gcctcggct  cagcgccat  gcgccctcc  ggaagttct  cgttggggg  aactggaag  600
tgaacgggc  gaagcagag  ctgggggag  tcatcggca  tctgaacgc  gccaaggtg  660
cggccgaca  cgaggtggt  tgtgctccc  ctactgcct  tatcgactt  gcccggcag  720
agctagatc  caagattgc  gtggctgcg  agaactgct  caaagtgac  aatggggct  780
ttactgggg  gatcagccc  ggcatgatc  aagactgcg  agccacgtg  gtggtcctg  840
ggcactcag  gagaaggca  gtctttggg  agtcagatg  gctgattgg  cagaaagtg  900
cccatgctc  ggcagaggg  ctcggagta  tcgcctgca  tggggagaa  ctagatgaa  960
gggaagctg  catcactga  aaggttgtt  tcgagcaga  aaaggtcat  gcagataac  1020
tgaaggact  gagcaaggt  gtcctggcc  atgagcctg  gtgggccat  ggtactggc  1080
agactgcaa  accccaaca  gcccaggaa  tacacgaga  gctccgagg  tggctgaag  1140
ccaacgtct  tgatgcggt  gctcagagc  cccgtatca  ttatggagg  tctgtgact  1200
gggcaacct  caaggagct  gccagccag  ctgatgtgg  tggcttcct  gtgggtggt  1260
cttccctca  gcccgaatt  gtggacatc  tcaatgcca  acaatgagc  ccatccatc  1320
tccctaccc  tcctgccaa  ccagggact  agcagccca  aagcccagt  actgccctt  1380
ccctgcata  gcttctgat  gtgtcatct  ctccttcct  tggcctcat  caaactgta  1440
cttccttta  tgtttatat  ttcaccctg  aatggttgg  accaggcca  tcccttctc  1500
acttactat  atggttgga  ctaaacgtc  ccaaggtgg  ttctccttg  ctgagagat  1560
gaaggcgtg  tgggatttg  tcctgggtt  cctaggccc  agtgagggc  gaagagaaa  1620
catcctctc  cttcttaca  cgtgaggcc  agatcccct  agaaggcag  agtgctgcc  1680
tctcccatg  tgcccgtgc  tctgtgctg  gtatgtgaa  cacccatgt  agggaataa  1740
cctggcact  ggtaaaaaa  aaaaaaaaa  aaaa  1774



<210> 447
<211> 248
<212> PRT
<213> Homo sapiens
<308> P00938
<400> 447

Ala Pro Ser Arg Lys Phe Phe Val Gly Gly Asn Trp Lys Met Asn Gly 
  1               5                  10                  15
Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly Thr Leu Asn Ala Ala Lys 
             20                  25                  30
Val Pro Ala Asp Thr Glu Val Val Cys Ala Pro Pro Thr Ala Tyr Ile 
         35                  40                  45
Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys Ile Ala Val Ala Ala Gln 
     50                  55                  60
Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe Thr Gly Glu Ile Ser Pro 
 65                  70                  75                  80
Gly Met Ile Lys Asp Cys Gly Ala Thr Trp Val Val Leu Gly His Ser 
                 85                  90                  95
Glu Arg Arg His Val Phe Gly Glu Ser Asp Glu Leu Ile Gly Gln Lys 
             100                105                110
Val Ala His Ala Leu Ala Glu Gly Leu Gly Val Ile Ala Cys Ile Gly 
         115                120                125
Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile Thr Glu Lys Val Val Phe 
     130                135                140
Glu Gln Thr Lys Val Ile Ala Asp Asn Val Lys Asp Trp Ser Lys Val 
 145                150                155                160
Val Leu Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys Thr Ala 
                 165                170                175
Thr Pro Gln Gln Ala Gln Glu Val His Glu Lys Leu Arg Gly Trp Leu 
             180                185                190
Lys Ser Asn Val Ser Asp Ala Val Ala Gln Ser Thr Arg Ile Ile Tyr 
         195                200                205
Gly Gly Ser Val Thr Gly Ala Thr Cys Lys Glu Leu Ala Ser Gln Pro 
     210                215                220
Asp Val Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys Pro Glu Phe 
 225                230                235                240
Val Asp Ile Ile Asn Ala Lys Gln 
                 245



<210> 448
<211> 4409
<212> DNA
<213> Rattus norvegicus
<308> AF008439
<400> 448

ccacgcgtc  gatggggaa  aagcagccg  gggcagcag  aagtgctgc  ccaaactgt  60
agctaaaat  ctattctaa  agcacagat  ctcaggtat  taccatggt  ttggatcct  120
aagaaaaga  tccagacga  ggtgcttct  gggaccatg  agactcggc  agcctcggt  180
ccatcaacc  tgcttacag  aactcttcc  tcccacatt  caccgggga  tctgaggag  240
ccttcacca  ctactttga  gagaaaatc  ccattcctg  ggaggagta  tcttgtttt  300
gtttccgta  actctgggc  ttcacagga  ctggttttc  tatgagcat  gcctacctg  360
atccaggaa  cattgaatc  gatttacag  ctggagcag  ggctggatt  aagttgctc  420
gggtgctcc  gctggccac  attgtgggg  tgctgctcc  gcgtctcgc  gctcgactg  480
gagtggtca  cggcttgca  cttgctgaa  tgtgtcacc  tcagtatcc  aaggtccca  540
ggatcatcc  gtggctaat  gtggagttg  caatcattg  ttctgatat  caggaagtc  600
ttggctcag  catcgccat  aatctcctg  ctgccggaa  ggttcccct  tatggtgga  660
tcctcatca  catcgcaga  acttttgta  ttctctttt  ggacaaata  ggcttgcgg  720
agctggaag  attttttgg  tttctcatc  ctatcatgg  cctcacatt  ggatatgag  780
atgttacag  gaaacccag  caaagccaa  tactcaggg  catgttcgt  ccatcctgt  840
caggctgcc  cacccctca  gtggagcag  cggtgggca  cgtgggagc  gtgatcatg  900
cacacaaca  gtacctgca  tctgcctta  tcaagtcta  acaagtgaa  cgggccaat  960
agcaggaag  tcgagaagc  aataagtac  tcttcatcg  gtcctgcat  gcactcttt  1020
tttccttca  catcaatgt  tttgtcgtc  ccgtctttg  tgaagcatt  tttgagaaa  1080
ccaatgagc  ggtggttga  gtctgcaga  atagcagca  cccccatgc  gacctcttt  1140
ctaacgaca  ctctaccct  gctgtggac  tctacaaag  gggtgttgt  cttggatgt  1200
acttcgggc  tgcggccct  tacatctgg  cggtgggga  cctggctgc  ggacagagc  1260
ccaccatga  tggaaccta  tctggccag  ttgtcatgg  gggattcct  aacctaaaa  1320
ggtcgcgct  tgcccgcgt  atcctgacc  ggtctattg  catcatccc  accctgctt  1380
ttgctgtct  ccaagatgt  gagcatctg  cagggatga  tgatttcct  aatgttctg  1440
agagcctac  gctcccctt  gccctcatc  ctatcctca  cttcacaag  ctgcggcca  1500
tgatgagtg  gttctccaa  ggaataggc  ggaggatcg  aggcggcat  ttggtcctt  1560
tcgtctgct  catcaacat  tactttgtc  tggtctacg  ccaggagct  gggcatgtg  1620
cactgtatg  ggtggctgc  gtggttagc  tggcttatc  gggctttgt  ttctacttg  1680
gttggcagt  tttgattgc  ttgggcctg  cgttcctgg  ctgtgggcg  tcggtaagc  1740
tctctaaag  cctgctgag  gaagatacc  gcggtggca  tactaagta  acactgggt  1800
agcctgtct  tctgtcttt  cagggagcc  tcagagcca  tgtgtttct  tggtttact  1860
tgtgaacat  gccacaagt  tgtgccgtt  cacagactg  atttaggga  caactgtta  1920
ttgggaaac  ctggggtgg  tgtgtggtg  gtgtgtgtg  gttgtttcc  tctgtcttt  1980
tcaaatagc  tgctgctat  aaatgcttg  tggcctaaa  ctctgtgta  cctaggctg  2040
cttcaaact  acagcaatc  tcctggctc  gcctcctgg  tgctgggat  ccaggcatg  2100
ctaccgctc  tggctgtca  gagtgctta  aagatgact  gttttgtca  gggaggtct  2160
accctgtag  attaggcag  accttgaaa  ggtgagcct  gagctgttt  gaacactaa  2220
ttcctaaat  gctgtccaa  gccatggct  ggttttagt  ctgagaaac  caaccagac  2280
gttgtcatc  tttgaattg  agaattaga  accgctatt  ttgagttca  gatttctgt  2340
tgtttggtg  atttcattt  gtttttcaa  acaagggtt  cttccttgt  gtcctggaa  2400
ttactctgt  gaccagcct  gctttgaac  cacagagat  ctcctgcct  tgcctctgc  2460
tcccgactg  taggattag  ggcatacac  accactgcc  tgctaagct  agagttttt  2520
atttctact  tggaattcc  cagtggaaa  aaaggtaga  caggagagg  ggtgtggtc  2580
agtgatggc  cccctccag  tccttgcag  tttacctta  ggagtggag  ttagcaggg  2640
ttcatctgt  gtcctgagg  tagtgactt  cctgttaat  gcaagcatc  cgatagtgt  2700
tcatctcga  tacacacag  cctggaatc  ccgccttcc  ctcctgaga  agtgcggat  2760
gcaaaagac  actgtagca  ttgtgaact  gctcacagc  aatcccaga  ctgaccgca  2820
tactcccga  agtaccctt  accaaatct  ggctctgac  caccgctgt  tcatgccca  2880
gataactca  aaggcaacc  caggagctc  ggacccaaa  cttgcaaag  cagtagttg  2940
cactgtgat  caaagtcct  tccctgcaa  gtgggacta  gctgcctcc  cacagccct  3000
ccctcggag  gaaagcctc  tgagaccag  ctgcggagc  ctggagatt  agcacggga  3060
tacagaact  ctgctctca  ttcagccac  tctgtcctg  cacgtggga  acatgattc  3120
gtcacatca  gtcctgtct  tttgctgga  aggaataat  caagtttgt  taatcattg  3180
cttggtggc  acaggagct  cagtgactt  gaaggatgt  gtcctcttt  ccgctttcc  3240
agttcgact  tcccgacaa  tgacctgca  tgtggtgcc  ctgtggcat  agtgctagc  3300
tttcacaca  tcagaagct  agcctgcat  gagtcctgt  aggcatgaa  ggtaaatgc  3360
gtttcactc  gcctggttg  cctcagccc  acagctaac  caacacagt  aggccgcgg  3420
tccctcact  cggcattct  aacccctgg  ttgccaccc  tttgcagcc  ctatatcca  3480
aaccattta  attatgatt  ataacagta  cagcattag  tgtgaaata  caaagattt  3540
atggttggg  gttaccacc  caaagggtc  cagcagcag  aagtttgag  accctgcac  3600
acagggtcc  tctcacacc  gcctctgcc  ccattgttc  caaaactga  tggaaactg  3660
gcttttgaa  ctgtctcga  gtggtgctt  agggccaga  tgacagtag  agaattact  3720
gaatggatg  tctagtgac  tctgcattt  tacaggggc  gggttgggc  gggcggggc  3780
gggttgggc  gggtgtgtt  agagtcact  tacttacag  ccagcccag  gctgctggc  3840
gtcatgccc  ggggtctgc  ttgtgcgtg  tagcaaggc  gtgctgcag  tctcacttc  3900
tgccccaga  ttctgctgt  gtatgttcg  ttacagtga  agacggttc  attgtgtac  3960
acggtctct  actctatgc  tacagtatt  acagtgtca  agattaaaa  tgtcgcctg  4020
ccatttggc  gtcactggg  aacagtgct  ccaacagtg  tctgtacgt  acctgtaag  4080
atttcaacc  cgccacgcc  gtgtggcct  gcgttacgt  ggcgagcca  cttgtacgt  4140
ctcacttgg  cctcgttct  ctgcgacct  aaatagttg  tccctctgc  ctgggagct  4200
gcggctggg  aacagcagc  gcttgtctt  taaggtcct  ccaggaggg  aacaagtga  4260
tataaggag  ctgttagtg  gcctctgac  gcttgtgaa  ttgctgtaa  taaaacaaa  4320
acttccctg  taaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  4380
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  4409



<210> 449
<211> 568
<212> PRT
<213> Rattus norvegicus
<308> O54902
<400> 449

Met Val Leu Asp Pro Glu Glu Lys Ile Pro Asp Asp Gly Ala Ser Gly 
  1               5                  10                  15
Asp His Gly Asp Ser Ala Ser Leu Gly Ala Ile Asn Pro Ala Tyr Ser 
             20                  25                  30
Asn Ser Ser Leu Pro His Ser Thr Gly Asp Ser Glu Glu Pro Phe Thr 
         35                  40                  45
Thr Tyr Phe Asp Glu Lys Ile Pro Ile Pro Glu Glu Glu Tyr Ser Cys 
     50                  55                  60
Phe Ser Phe Arg Lys Leu Trp Ala Phe Thr Gly Pro Gly Phe Leu Met 
 65                  70                  75                  80
Ser Ile Ala Tyr Leu Asp Pro Gly Asn Ile Glu Ser Asp Leu Gln Ser 
                 85                  90                  95
Gly Ala Val Ala Gly Phe Lys Leu Leu Trp Val Leu Leu Leu Ala Thr 
             100                105                110
Ile Val Gly Leu Leu Leu Gln Arg Leu Ala Ala Arg Leu Gly Val Val 
         115                120                125
Thr Gly Leu His Leu Ala Glu Val Cys His Arg Gln Tyr Pro Lys Val 
     130                135                140
Pro Arg Ile Ile Leu Trp Leu Met Val Glu Leu Ala Ile Ile Gly Ser 
 145                150                155                160
Asp Met Gln Glu Val Ile Gly Ser Ala Ile Ala Ile Asn Leu Leu Ser 
                 165                170                175
Ala Gly Arg Val Pro Leu Tyr Gly Gly Val Leu Ile Thr Ile Ala Asp 
             180                185                190
Thr Phe Val Phe Leu Phe Leu Asp Lys Tyr Gly Leu Arg Lys Leu Glu 
         195                200                205
Ala Phe Phe Gly Phe Leu Ile Thr Ile Met Ala Leu Thr Phe Gly Tyr 
     210                215                220
Glu Tyr Val Thr Val Lys Pro Ser Gln Ser Gln Val Leu Arg Gly Met 
 225                230                235                240
Phe Val Pro Ser Cys Ser Gly Cys His Thr Pro Gln Val Glu Gln Ala 
                 245                250                255
Val Gly Ile Val Gly Ala Val Ile Met Pro His Asn Met Tyr Leu His 
             260                265                270
Ser Ala Leu Val Lys Ser Arg Gln Val Asn Arg Ala Asn Lys Gln Glu 
         275                280                285
Val Arg Glu Ala Asn Lys Tyr Phe Phe Ile Glu Ser Cys Ile Ala Leu 
     290                295                300
Phe Val Ser Phe Ile Ile Asn Val Phe Val Val Ser Val Phe Ala Glu 
 305                310                315                320
Ala Phe Phe Glu Lys Thr Asn Glu Gln Val Val Glu Val Cys Arg Asn 
                 325                330                335
Ser Ser Ser Pro His Ala Asp Leu Phe Pro Asn Asp Asn Ser Thr Leu 
             340                345                350
Ala Val Asp Ile Tyr Lys Gly Gly Val Val Leu Gly Cys Tyr Phe Gly 
         355                360                365
Pro Ala Ala Leu Tyr Ile Trp Ala Val Gly Ile Leu Ala Ala Gly Gln 
     370                375                380
Ser Ser Thr Met Thr Gly Thr Tyr Ser Gly Gln Phe Val Met Glu Gly 
 385                390                395                400
Phe Leu Asn Leu Lys Trp Ser Arg Phe Ala Arg Val Ile Leu Thr Arg 
                 405                410                415
Ser Ile Ala Ile Ile Pro Thr Leu Leu Val Ala Val Phe Gln Asp Val 
             420                425                430
Glu His Leu Thr Gly Met Asn Asp Phe Leu Asn Val Leu Gln Ser Leu 
         435                440                445
Gln Leu Pro Phe Ala Leu Ile Pro Ile Leu Thr Phe Thr Ser Leu Arg 
     450                455                460
Pro Val Met Ser Glu Phe Ser Asn Gly Ile Gly Trp Arg Ile Ala Gly 
 465                470                475                480
Gly Ile Leu Val Leu Leu Val Cys Ser Ile Asn Met Tyr Phe Val Val 
                 485                490                495
Val Tyr Val Gln Glu Leu Gly His Val Ala Leu Tyr Val Val Ala Ala 
             500                505                510
Val Val Ser Val Ala Tyr Leu Gly Phe Val Phe Tyr Leu Gly Trp Gln 
         515                520                525
Cys Leu Ile Ala Leu Gly Leu Ser Phe Leu Asp Cys Gly Arg Ser Tyr 
     530                535                540
His Leu Gly Leu Thr Ala Arg Pro Glu Ile Tyr Leu Leu Asn Thr Val 
 545                550                555                560
Asp Ala Val Ser Leu Val Ser Arg 
                 565



<210> 450
<211> 4103
<212> DNA
<213> Homo sapiens
<308> AB004857
<400> 450

ggagccctg  gcgcggggg  ggcgtgtca  gtggttgcg  agctggtaa  aatcatatt  60
taagaactc  gccactcag  tatccacca  ggtgctggg  cctgaacag  agatgtcag  120
tgacagtgt  tctggagat  atggggagt  tgccagtct  ggtaacatc  accctgcct  180
tagtaatcc  tctctttca  agtcccctg  ggactcaga  gagtacttc  ccacttact  240
taatgagaa  atctccatt  ctgaggagg  gtactcttg  tttagcttt  gtaaactct  300
ggctttcac  ggaccaggt  ttcttatga  cattgccta  ctggatcca  gaaatattg  360
atccgattt  cagtctgga  cagtggctg  atttaagtt  ctctggatc  ttctgttgg  420
cacccttgt  gggctgctg  tccagcggc  tgcagctag  ctgggagtg  ttactgggc  480
gcatcttgc  gaagtatgt  accgtcagt  tcccaaggt  ccacgagtc  tcctgtggc  540
gatggtgga  ttggctatc  tcggctcag  catgcaaga  gtcattggc  cagccattg  600
tatcaatct  ctgtctgta  gaagaattc  tctgtgggg  ggcgttctc  tcaccattg  660
agatacttt  gtatttctc  tcttggaca  atatggctt  cggaagcta  aagcatttt  720
tggctttct  atcactatt  tggccctca  atttggata  gagtatgtt  cagtgaaac  780
cagccagag  caggtactc  agggcatgt  cgtaccatc  tgttcaggc  gtcgcactc  840
acagattga  caggctgtg  gcatcgtgg  agctgtcat  atgccacac  acatgtacc  900
gcattctgc  ttagtcaag  ctagacagg  aaaccggaa  aataagcag  aagttcgag  960
agccaataa  tactttttc  ttgaatcct  cattgcact  tttgtttcc  tcatcatca  1020
tgtctttgt  gtctcagtc  ttgctgaag  attttttgg  aaaaccaac  agcaggtgg  1080
tgaagtctg  acaaatacc  gcagtcctc  tgctggcct  tttcctaaa  ataactcga  1140
actggctgt  gacatctac  aagggggtg  tgtgctggg  tgttacttt  ggcctgctg  1200
actctacat  tgggcagtg  ggatcctgg  tgcaggaca  agctccacc  tgacaggaa  1260
ctattctgg  cagtttgtc  tggagggat  cctgaacct  aagtggtca  gctttgccc  1320
agtggttct  actcgctct  ttgccatca  ccccactct  cttgttgct  tcttccaag  1380
tgtagagca  ctaacaggg  tgaatgact  tctgaatgt  ctacagagc  tacagcttc  1440
ctttgctct  atacccatc  tcacattta  gagcttgcg  ccagtaatg  gtgactttg  1500
caatggact  ggctggcgg  ttgcaggag  aatcttggt  cttatcatc  gttccatca  1560
tatgtactt  gtagtggtt  atgtccggg  cctagggca  gtggcatta  atgtggtgg  1620
tgctgtggt  agcgtggct  atctgggct  tgtgttcta  ttgggttgg  aatgtttga  1680
tgcactggg  atgtccttc  tggactgtg  gcatacggt  agcatctct  aaggcctgc  1740
gacagaaga  gccacccgt  gctacgtta  ataacactg  attagtctg  cttctgcag  1800
tagccatca  agccagtgt  tttctatgg  ttactgtgt  aacatagcc  aaagtatgt  1860
ccgttgcac  gactgtgtt  atgactcaa  cgttggttg  aaaagactt  gtttcatgt  1920
tatttgaaa  atggaatta  tttttcctt  ctgacctaa  cttagaact  gattagggt  1980
ggatctttg  aaagctgac  tttgctgct  tcattccaa  actaaattc  taagtagtt  2040
cccaagggc  agctcagtt  atccttcgg  gagacaagg  tatgcatga  tcttaacca  2100
gctatatgt  aaaaaaaaa  tggaaaatg  aatacattt  ttattatac  aactacaga  2160
tgagtatgc  agttttatt  atcaaaatg  aatggattt  taaaggctg  gaaattttc  2220
ttataccta  cttttcagt  attttaatt  taccaaatt  tcaactaga  tagcttcat  2280
catatgaaa  ataaaatga  gagacacct  gctctatca  gcttaggat  ctttgaact  2340
atttccact  taatttctc  gtggaagtt  agaggggtg  gaaaacaaa  aaggggaaa  2400
actgacaac  aacaaaacc  gcaccacat  gctaggtgg  gcttactaa  taccttctc  2460
ggattttcc  cagattgaa  agcttatga  gatttcttg  gagtcttaa  aacctgcct  2520
ttagtacag  gctttcctg  tgatattta  tcttgagca  atgtggttg  aaaacctta  2580
ctttctttc  ccaggaggg  ggtgataga  acagatggt  gtatttatg  actgatgtt  2640
tcgtgaaat  ttgagggtg  ggagaaaag  ctttaaggg  ggagagcca  ctattttgt  2700
cctaaagcc  cctctcagc  gaatcgtca  gtttttctg  tgcaccgct  tgcttcatg  2760
ccaagatga  ttgcgaggc  atctcagga  ctgtggact  aaccgttgc  aagcacact  2820
tctttctca  cgttctctg  aagtcagta  gtgttagta  ggttgcaaa  ttcactgtc  2880
cagcaaagt  gaactgggc  acctctcta  agctgtttc  tcagaggga  aaatcttga  2940
accatggtg  agctctgga  tcagaggaa  tgggtgtct  cagcacaaa  ctgctgctt  3000
tacttcagc  acttctgac  tttttacat  ccgagcctg  gattgtgtg  ttatctcaa  3060
tcaaatcac  ttgatggag  taaataatc  aaactgttt  atagtcatt  atttggtga  3120
aacagtaat  gaaaatggt  ttgaaggac  tctcatttt  ggagctttc  ttccagagt  3180
ctggctgat  ggtgttcgc  gttcatctg  gcccccaaa  gcattatta  tgatacttg  3240
acacagtca  aagcgcaga  tggatggat  gtcttttat  aggcattta  gggtacact  3300
ctgtgtttc  ctgaccata  atttttctt  gcccctcaa  taatatagc  cagagttat  3360
aatgacaat  cccctaacc  ttcctcttc  tatctgcct  ttcccctta  catcgtaat  3420
ctccaaact  gtcataaag  cactctgtg  agatattgg  gactgacat  ttaagctct  3480
acctggctg  agtaggaaa  gccaaactg  cgacaaaaa  aaaattctt  ataaagatg  3540
tatggtaac  tgtatcttt  ccctgggtc  gggtgggtc  agtcagtct  agatttaca  3600
gcatttagg  gcctaggta  aagctgcta  tattctttt  aaagttata  ttatgactt  3660
caatgatag  aaactcctt  caattaaat  gcattttat  atattatgt  tgtacttca  3720
agtgttaaa  ataccctca  acgttattg  atttgatct  cacagaaag  gcattttaa  3780
cagtactct  ggtgcaata  ataatatgt  gaaatttaa  tcctccaat  ccagcatat  3840
cagtgagtt  tgacagtgt  tttatgtgg  atgtttaag  atatacaat  gtactttat  3900
taaattggt  cttgttctt  ttaaatgtg  catgaaata  ttgtgctgc  acattatac  3960
ggaaattaa  aggggaaaa  ggaagagct  ttggctccc  tgaggttct  ctagtggtg  4020
taggagtgg  tacaactga  cttttagta  ccatttaac  gtatgtaaa  ttggtttct  4080
attaaaaaa  aatttcttt  tcc  4103



<210> 451
<211> 568
<212> PRT
<213> Homo sapiens
<308> P49281
<400> 451

Met Val Leu Gly Pro Glu Gln Lys Met Ser Asp Asp Ser Val Ser Gly 
  1               5                  10                  15
Asp His Gly Glu Ser Ala Ser Leu Gly Asn Ile Asn Pro Ala Tyr Ser 
             20                  25                  30
Asn Pro Ser Leu Ser Gln Ser Pro Gly Asp Ser Glu Glu Tyr Phe Ala 
         35                  40                  45
Thr Tyr Phe Asn Glu Lys Ile Ser Ile Pro Glu Glu Glu Tyr Ser Cys 
     50                  55                  60
Phe Ser Phe Arg Lys Leu Trp Ala Phe Thr Gly Pro Gly Phe Leu Met 
 65                  70                  75                  80
Ser Ile Ala Tyr Leu Asp Pro Gly Asn Ile Glu Ser Asp Leu Gln Ser 
                 85                  90                  95
Gly Ala Val Ala Gly Phe Lys Leu Leu Trp Ile Leu Leu Leu Ala Thr 
             100                105                110
Leu Val Gly Leu Leu Leu Gln Arg Leu Ala Ala Arg Leu Gly Val Val 
         115                120                125
Thr Gly Leu His Leu Ala Glu Val Cys His Arg Gln Tyr Pro Lys Val 
     130                135                140
Pro Arg Val Ile Leu Trp Leu Met Val Glu Leu Ala Ile Ile Gly Ser 
 145                150                155                160
Asp Met Gln Glu Val Ile Gly Ser Ala Ile Ala Ile Asn Leu Leu Ser 
                 165                170                175
Val Gly Arg Ile Pro Leu Trp Gly Gly Val Leu Ile Thr Ile Ala Asp 
             180                185                190
Thr Phe Val Phe Leu Phe Leu Asp Lys Tyr Gly Leu Arg Lys Leu Glu 
         195                200                205
Ala Phe Phe Gly Phe Leu Ile Thr Ile Met Ala Leu Thr Phe Gly Tyr 
     210                215                220
Glu Tyr Val Thr Val Lys Pro Ser Gln Ser Gln Val Leu Lys Gly Met 
 225                230                235                240
Phe Val Pro Ser Cys Ser Gly Cys Arg Thr Pro Gln Ile Glu Gln Ala 
                 245                250                255
Val Gly Ile Val Gly Ala Val Ile Met Pro His Asn Met Tyr Leu His 
             260                265                270
Ser Ala Leu Val Lys Ser Arg Gln Val Asn Arg Asn Asn Lys Gln Glu 
         275                280                285
Val Arg Glu Ala Asn Lys Tyr Phe Phe Ile Glu Ser Cys Ile Ala Leu 
     290                295                300
Phe Val Ser Phe Ile Ile Asn Val Phe Val Val Ser Val Phe Ala Glu 
 305                310                315                320
Ala Phe Phe Gly Lys Thr Asn Glu Gln Val Val Glu Val Cys Thr Asn 
                 325                330                335
Thr Ser Ser Pro His Ala Gly Leu Phe Pro Lys Asp Asn Ser Thr Leu 
             340                345                350
Ala Val Asp Ile Tyr Lys Gly Gly Val Val Leu Gly Cys Tyr Phe Gly 
         355                360                365
Pro Ala Ala Leu Tyr Ile Trp Ala Val Gly Ile Leu Ala Ala Gly Gln 
     370                375                380
Ser Ser Thr Met Thr Gly Thr Tyr Ser Gly Gln Phe Val Met Glu Gly 
 385                390                395                400
Phe Leu Asn Leu Lys Trp Ser Arg Phe Ala Arg Val Val Leu Thr Arg 
                 405                410                415
Ser Ile Ala Ile Ile Pro Thr Leu Leu Val Ala Val Phe Gln Asp Val 
             420                425                430
Glu His Leu Thr Gly Met Asn Asp Phe Leu Asn Val Leu Gln Ser Leu 
         435                440                445
Gln Leu Pro Phe Ala Leu Ile Pro Ile Leu Thr Phe Thr Ser Leu Arg 
     450                455                460
Pro Val Met Ser Asp Phe Ala Asn Gly Leu Gly Trp Arg Ile Ala Gly 
 465                470                475                480
Gly Ile Leu Val Leu Ile Ile Cys Ser Ile Asn Met Tyr Phe Val Val 
                 485                490                495
Val Tyr Val Arg Asp Leu Gly His Val Ala Leu Tyr Val Val Ala Ala 
             500                505                510
Val Val Ser Val Ala Tyr Leu Gly Phe Val Phe Tyr Leu Gly Trp Gln 
         515                520                525
Cys Leu Ile Ala Leu Gly Met Ser Phe Leu Asp Cys Gly His Thr Cys 
     530                535                540
His Leu Gly Leu Thr Ala Gln Pro Glu Leu Tyr Leu Leu Asn Thr Met 
 545                550                555                560
Asp Ala Asp Ser Leu Val Ser Arg 
                 565



<210> 452
<211> 4409
<212> DNA
<213> Rattus norvegicus
<308> AF008439
<400> 452

ccacgcgtc  gatggggaa  aagcagccg  gggcagcag  aagtgctgc  ccaaactgt  60
agctaaaat  ctattctaa  agcacagat  ctcaggtat  taccatggt  ttggatcct  120
aagaaaaga  tccagacga  ggtgcttct  gggaccatg  agactcggc  agcctcggt  180
ccatcaacc  tgcttacag  aactcttcc  tcccacatt  caccgggga  tctgaggag  240
ccttcacca  ctactttga  gagaaaatc  ccattcctg  ggaggagta  tcttgtttt  300
gtttccgta  actctgggc  ttcacagga  ctggttttc  tatgagcat  gcctacctg  360
atccaggaa  cattgaatc  gatttacag  ctggagcag  ggctggatt  aagttgctc  420
gggtgctcc  gctggccac  attgtgggg  tgctgctcc  gcgtctcgc  gctcgactg  480
gagtggtca  cggcttgca  cttgctgaa  tgtgtcacc  tcagtatcc  aaggtccca  540
ggatcatcc  gtggctaat  gtggagttg  caatcattg  ttctgatat  caggaagtc  600
ttggctcag  catcgccat  aatctcctg  ctgccggaa  ggttcccct  tatggtgga  660
tcctcatca  catcgcaga  acttttgta  ttctctttt  ggacaaata  ggcttgcgg  720
agctggaag  attttttgg  tttctcatc  ctatcatgg  cctcacatt  ggatatgag  780
atgttacag  gaaacccag  caaagccaa  tactcaggg  catgttcgt  ccatcctgt  840
caggctgcc  cacccctca  gtggagcag  cggtgggca  cgtgggagc  gtgatcatg  900
cacacaaca  gtacctgca  tctgcctta  tcaagtcta  acaagtgaa  cgggccaat  960
agcaggaag  tcgagaagc  aataagtac  tcttcatcg  gtcctgcat  gcactcttt  1020
tttccttca  catcaatgt  tttgtcgtc  ccgtctttg  tgaagcatt  tttgagaaa  1080
ccaatgagc  ggtggttga  gtctgcaga  atagcagca  cccccatgc  gacctcttt  1140
ctaacgaca  ctctaccct  gctgtggac  tctacaaag  gggtgttgt  cttggatgt  1200
acttcgggc  tgcggccct  tacatctgg  cggtgggga  cctggctgc  ggacagagc  1260
ccaccatga  tggaaccta  tctggccag  ttgtcatgg  gggattcct  aacctaaaa  1320
ggtcgcgct  tgcccgcgt  atcctgacc  ggtctattg  catcatccc  accctgctt  1380
ttgctgtct  ccaagatgt  gagcatctg  cagggatga  tgatttcct  aatgttctg  1440
agagcctac  gctcccctt  gccctcatc  ctatcctca  cttcacaag  ctgcggcca  1500
tgatgagtg  gttctccaa  ggaataggc  ggaggatcg  aggcggcat  ttggtcctt  1560
tcgtctgct  catcaacat  tactttgtc  tggtctacg  ccaggagct  gggcatgtg  1620
cactgtatg  ggtggctgc  gtggttagc  tggcttatc  gggctttgt  ttctacttg  1680
gttggcagt  tttgattgc  ttgggcctg  cgttcctgg  ctgtgggcg  tcggtaagc  1740
tctctaaag  cctgctgag  gaagatacc  gcggtggca  tactaagta  acactgggt  1800
agcctgtct  tctgtcttt  cagggagcc  tcagagcca  tgtgtttct  tggtttact  1860
tgtgaacat  gccacaagt  tgtgccgtt  cacagactg  atttaggga  caactgtta  1920
ttgggaaac  ctggggtgg  tgtgtggtg  gtgtgtgtg  gttgtttcc  tctgtcttt  1980
tcaaatagc  tgctgctat  aaatgcttg  tggcctaaa  ctctgtgta  cctaggctg  2040
cttcaaact  acagcaatc  tcctggctc  gcctcctgg  tgctgggat  ccaggcatg  2100
ctaccgctc  tggctgtca  gagtgctta  aagatgact  gttttgtca  gggaggtct  2160
accctgtag  attaggcag  accttgaaa  ggtgagcct  gagctgttt  gaacactaa  2220
ttcctaaat  gctgtccaa  gccatggct  ggttttagt  ctgagaaac  caaccagac  2280
gttgtcatc  tttgaattg  agaattaga  accgctatt  ttgagttca  gatttctgt  2340
tgtttggtg  atttcattt  gtttttcaa  acaagggtt  cttccttgt  gtcctggaa  2400
ttactctgt  gaccagcct  gctttgaac  cacagagat  ctcctgcct  tgcctctgc  2460
tcccgactg  taggattag  ggcatacac  accactgcc  tgctaagct  agagttttt  2520
atttctact  tggaattcc  cagtggaaa  aaaggtaga  caggagagg  ggtgtggtc  2580
agtgatggc  cccctccag  tccttgcag  tttacctta  ggagtggag  ttagcaggg  2640
ttcatctgt  gtcctgagg  tagtgactt  cctgttaat  gcaagcatc  cgatagtgt  2700
tcatctcga  tacacacag  cctggaatc  ccgccttcc  ctcctgaga  agtgcggat  2760
gcaaaagac  actgtagca  ttgtgaact  gctcacagc  aatcccaga  ctgaccgca  2820
tactcccga  agtaccctt  accaaatct  ggctctgac  caccgctgt  tcatgccca  2880
gataactca  aaggcaacc  caggagctc  ggacccaaa  cttgcaaag  cagtagttg  2940
cactgtgat  caaagtcct  tccctgcaa  gtgggacta  gctgcctcc  cacagccct  3000
ccctcggag  gaaagcctc  tgagaccag  ctgcggagc  ctggagatt  agcacggga  3060
tacagaact  ctgctctca  ttcagccac  tctgtcctg  cacgtggga  acatgattc  3120
gtcacatca  gtcctgtct  tttgctgga  aggaataat  caagtttgt  taatcattg  3180
cttggtggc  acaggagct  cagtgactt  gaaggatgt  gtcctcttt  ccgctttcc  3240
agttcgact  tcccgacaa  tgacctgca  tgtggtgcc  ctgtggcat  agtgctagc  3300
tttcacaca  tcagaagct  agcctgcat  gagtcctgt  aggcatgaa  ggtaaatgc  3360
gtttcactc  gcctggttg  cctcagccc  acagctaac  caacacagt  aggccgcgg  3420
tccctcact  cggcattct  aacccctgg  ttgccaccc  tttgcagcc  ctatatcca  3480
aaccattta  attatgatt  ataacagta  cagcattag  tgtgaaata  caaagattt  3540
atggttggg  gttaccacc  caaagggtc  cagcagcag  aagtttgag  accctgcac  3600
acagggtcc  tctcacacc  gcctctgcc  ccattgttc  caaaactga  tggaaactg  3660
gcttttgaa  ctgtctcga  gtggtgctt  agggccaga  tgacagtag  agaattact  3720
gaatggatg  tctagtgac  tctgcattt  tacaggggc  gggttgggc  gggcggggc  3780
gggttgggc  gggtgtgtt  agagtcact  tacttacag  ccagcccag  gctgctggc  3840
gtcatgccc  ggggtctgc  ttgtgcgtg  tagcaaggc  gtgctgcag  tctcacttc  3900
tgccccaga  ttctgctgt  gtatgttcg  ttacagtga  agacggttc  attgtgtac  3960
acggtctct  actctatgc  tacagtatt  acagtgtca  agattaaaa  tgtcgcctg  4020
ccatttggc  gtcactggg  aacagtgct  ccaacagtg  tctgtacgt  acctgtaag  4080
atttcaacc  cgccacgcc  gtgtggcct  gcgttacgt  ggcgagcca  cttgtacgt  4140
ctcacttgg  cctcgttct  ctgcgacct  aaatagttg  tccctctgc  ctgggagct  4200
gcggctggg  aacagcagc  gcttgtctt  taaggtcct  ccaggaggg  aacaagtga  4260
tataaggag  ctgttagtg  gcctctgac  gcttgtgaa  ttgctgtaa  taaaacaaa  4320
acttccctg  taaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  4380
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  4409



<210> 453
<211> 568
<212> PRT
<213> Rattus norvegicus
<308> O54902
<400> 453

Met Val Leu Asp Pro Glu Glu Lys Ile Pro Asp Asp Gly Ala Ser Gly 
  1               5                  10                  15
Asp His Gly Asp Ser Ala Ser Leu Gly Ala Ile Asn Pro Ala Tyr Ser 
             20                  25                  30
Asn Ser Ser Leu Pro His Ser Thr Gly Asp Ser Glu Glu Pro Phe Thr 
         35                  40                  45
Thr Tyr Phe Asp Glu Lys Ile Pro Ile Pro Glu Glu Glu Tyr Ser Cys 
     50                  55                  60
Phe Ser Phe Arg Lys Leu Trp Ala Phe Thr Gly Pro Gly Phe Leu Met 
 65                  70                  75                  80
Ser Ile Ala Tyr Leu Asp Pro Gly Asn Ile Glu Ser Asp Leu Gln Ser 
                 85                  90                  95
Gly Ala Val Ala Gly Phe Lys Leu Leu Trp Val Leu Leu Leu Ala Thr 
             100                105                110
Ile Val Gly Leu Leu Leu Gln Arg Leu Ala Ala Arg Leu Gly Val Val 
         115                120                125
Thr Gly Leu His Leu Ala Glu Val Cys His Arg Gln Tyr Pro Lys Val 
     130                135                140
Pro Arg Ile Ile Leu Trp Leu Met Val Glu Leu Ala Ile Ile Gly Ser 
 145                150                155                160
Asp Met Gln Glu Val Ile Gly Ser Ala Ile Ala Ile Asn Leu Leu Ser 
                 165                170                175
Ala Gly Arg Val Pro Leu Tyr Gly Gly Val Leu Ile Thr Ile Ala Asp 
             180                185                190
Thr Phe Val Phe Leu Phe Leu Asp Lys Tyr Gly Leu Arg Lys Leu Glu 
         195                200                205
Ala Phe Phe Gly Phe Leu Ile Thr Ile Met Ala Leu Thr Phe Gly Tyr 
     210                215                220
Glu Tyr Val Thr Val Lys Pro Ser Gln Ser Gln Val Leu Arg Gly Met 
 225                230                235                240
Phe Val Pro Ser Cys Ser Gly Cys His Thr Pro Gln Val Glu Gln Ala 
                 245                250                255
Val Gly Ile Val Gly Ala Val Ile Met Pro His Asn Met Tyr Leu His 
             260                265                270
Ser Ala Leu Val Lys Ser Arg Gln Val Asn Arg Ala Asn Lys Gln Glu 
         275                280                285
Val Arg Glu Ala Asn Lys Tyr Phe Phe Ile Glu Ser Cys Ile Ala Leu 
     290                295                300
Phe Val Ser Phe Ile Ile Asn Val Phe Val Val Ser Val Phe Ala Glu 
 305                310                315                320
Ala Phe Phe Glu Lys Thr Asn Glu Gln Val Val Glu Val Cys Arg Asn 
                 325                330                335
Ser Ser Ser Pro His Ala Asp Leu Phe Pro Asn Asp Asn Ser Thr Leu 
             340                345                350
Ala Val Asp Ile Tyr Lys Gly Gly Val Val Leu Gly Cys Tyr Phe Gly 
         355                360                365
Pro Ala Ala Leu Tyr Ile Trp Ala Val Gly Ile Leu Ala Ala Gly Gln 
     370                375                380
Ser Ser Thr Met Thr Gly Thr Tyr Ser Gly Gln Phe Val Met Glu Gly 
 385                390                395                400
Phe Leu Asn Leu Lys Trp Ser Arg Phe Ala Arg Val Ile Leu Thr Arg 
                 405                410                415
Ser Ile Ala Ile Ile Pro Thr Leu Leu Val Ala Val Phe Gln Asp Val 
             420                425                430
Glu His Leu Thr Gly Met Asn Asp Phe Leu Asn Val Leu Gln Ser Leu 
         435                440                445
Gln Leu Pro Phe Ala Leu Ile Pro Ile Leu Thr Phe Thr Ser Leu Arg 
     450                455                460
Pro Val Met Ser Glu Phe Ser Asn Gly Ile Gly Trp Arg Ile Ala Gly 
 465                470                475                480
Gly Ile Leu Val Leu Leu Val Cys Ser Ile Asn Met Tyr Phe Val Val 
                 485                490                495
Val Tyr Val Gln Glu Leu Gly His Val Ala Leu Tyr Val Val Ala Ala 
             500                505                510
Val Val Ser Val Ala Tyr Leu Gly Phe Val Phe Tyr Leu Gly Trp Gln 
         515                520                525
Cys Leu Ile Ala Leu Gly Leu Ser Phe Leu Asp Cys Gly Arg Ser Tyr 
     530                535                540
His Leu Gly Leu Thr Ala Arg Pro Glu Ile Tyr Leu Leu Asn Thr Val 
 545                550                555                560
Asp Ala Val Ser Leu Val Ser Arg 
                 565



<210> 454
<211> 4103
<212> DNA
<213> Homo sapiens
<308> AB004857
<400> 454

ggagccctg  gcgcggggg  ggcgtgtca  gtggttgcg  agctggtaa  aatcatatt  60
taagaactc  gccactcag  tatccacca  ggtgctggg  cctgaacag  agatgtcag  120
tgacagtgt  tctggagat  atggggagt  tgccagtct  ggtaacatc  accctgcct  180
tagtaatcc  tctctttca  agtcccctg  ggactcaga  gagtacttc  ccacttact  240
taatgagaa  atctccatt  ctgaggagg  gtactcttg  tttagcttt  gtaaactct  300
ggctttcac  ggaccaggt  ttcttatga  cattgccta  ctggatcca  gaaatattg  360
atccgattt  cagtctgga  cagtggctg  atttaagtt  ctctggatc  ttctgttgg  420
cacccttgt  gggctgctg  tccagcggc  tgcagctag  ctgggagtg  ttactgggc  480
gcatcttgc  gaagtatgt  accgtcagt  tcccaaggt  ccacgagtc  tcctgtggc  540
gatggtgga  ttggctatc  tcggctcag  catgcaaga  gtcattggc  cagccattg  600
tatcaatct  ctgtctgta  gaagaattc  tctgtgggg  ggcgttctc  tcaccattg  660
agatacttt  gtatttctc  tcttggaca  atatggctt  cggaagcta  aagcatttt  720
tggctttct  atcactatt  tggccctca  atttggata  gagtatgtt  cagtgaaac  780
cagccagag  caggtactc  agggcatgt  cgtaccatc  tgttcaggc  gtcgcactc  840
acagattga  caggctgtg  gcatcgtgg  agctgtcat  atgccacac  acatgtacc  900
gcattctgc  ttagtcaag  ctagacagg  aaaccggaa  aataagcag  aagttcgag  960
agccaataa  tactttttc  ttgaatcct  cattgcact  tttgtttcc  tcatcatca  1020
tgtctttgt  gtctcagtc  ttgctgaag  attttttgg  aaaaccaac  agcaggtgg  1080
tgaagtctg  acaaatacc  gcagtcctc  tgctggcct  tttcctaaa  ataactcga  1140
actggctgt  gacatctac  aagggggtg  tgtgctggg  tgttacttt  ggcctgctg  1200
actctacat  tgggcagtg  ggatcctgg  tgcaggaca  agctccacc  tgacaggaa  1260
ctattctgg  cagtttgtc  tggagggat  cctgaacct  aagtggtca  gctttgccc  1320
agtggttct  actcgctct  ttgccatca  ccccactct  cttgttgct  tcttccaag  1380
tgtagagca  ctaacaggg  tgaatgact  tctgaatgt  ctacagagc  tacagcttc  1440
ctttgctct  atacccatc  tcacattta  gagcttgcg  ccagtaatg  gtgactttg  1500
caatggact  ggctggcgg  ttgcaggag  aatcttggt  cttatcatc  gttccatca  1560
tatgtactt  gtagtggtt  atgtccggg  cctagggca  gtggcatta  atgtggtgg  1620
tgctgtggt  agcgtggct  atctgggct  tgtgttcta  ttgggttgg  aatgtttga  1680
tgcactggg  atgtccttc  tggactgtg  gcatacggt  agcatctct  aaggcctgc  1740
gacagaaga  gccacccgt  gctacgtta  ataacactg  attagtctg  cttctgcag  1800
tagccatca  agccagtgt  tttctatgg  ttactgtgt  aacatagcc  aaagtatgt  1860
ccgttgcac  gactgtgtt  atgactcaa  cgttggttg  aaaagactt  gtttcatgt  1920
tatttgaaa  atggaatta  tttttcctt  ctgacctaa  cttagaact  gattagggt  1980
ggatctttg  aaagctgac  tttgctgct  tcattccaa  actaaattc  taagtagtt  2040
cccaagggc  agctcagtt  atccttcgg  gagacaagg  tatgcatga  tcttaacca  2100
gctatatgt  aaaaaaaaa  tggaaaatg  aatacattt  ttattatac  aactacaga  2160
tgagtatgc  agttttatt  atcaaaatg  aatggattt  taaaggctg  gaaattttc  2220
ttataccta  cttttcagt  attttaatt  taccaaatt  tcaactaga  tagcttcat  2280
catatgaaa  ataaaatga  gagacacct  gctctatca  gcttaggat  ctttgaact  2340
atttccact  taatttctc  gtggaagtt  agaggggtg  gaaaacaaa  aaggggaaa  2400
actgacaac  aacaaaacc  gcaccacat  gctaggtgg  gcttactaa  taccttctc  2460
ggattttcc  cagattgaa  agcttatga  gatttcttg  gagtcttaa  aacctgcct  2520
ttagtacag  gctttcctg  tgatattta  tcttgagca  atgtggttg  aaaacctta  2580
ctttctttc  ccaggaggg  ggtgataga  acagatggt  gtatttatg  actgatgtt  2640
tcgtgaaat  ttgagggtg  ggagaaaag  ctttaaggg  ggagagcca  ctattttgt  2700
cctaaagcc  cctctcagc  gaatcgtca  gtttttctg  tgcaccgct  tgcttcatg  2760
ccaagatga  ttgcgaggc  atctcagga  ctgtggact  aaccgttgc  aagcacact  2820
tctttctca  cgttctctg  aagtcagta  gtgttagta  ggttgcaaa  ttcactgtc  2880
cagcaaagt  gaactgggc  acctctcta  agctgtttc  tcagaggga  aaatcttga  2940
accatggtg  agctctgga  tcagaggaa  tgggtgtct  cagcacaaa  ctgctgctt  3000
tacttcagc  acttctgac  tttttacat  ccgagcctg  gattgtgtg  ttatctcaa  3060
tcaaatcac  ttgatggag  taaataatc  aaactgttt  atagtcatt  atttggtga  3120
aacagtaat  gaaaatggt  ttgaaggac  tctcatttt  ggagctttc  ttccagagt  3180
ctggctgat  ggtgttcgc  gttcatctg  gcccccaaa  gcattatta  tgatacttg  3240
acacagtca  aagcgcaga  tggatggat  gtcttttat  aggcattta  gggtacact  3300
ctgtgtttc  ctgaccata  atttttctt  gcccctcaa  taatatagc  cagagttat  3360
aatgacaat  cccctaacc  ttcctcttc  tatctgcct  ttcccctta  catcgtaat  3420
ctccaaact  gtcataaag  cactctgtg  agatattgg  gactgacat  ttaagctct  3480
acctggctg  agtaggaaa  gccaaactg  cgacaaaaa  aaaattctt  ataaagatg  3540
tatggtaac  tgtatcttt  ccctgggtc  gggtgggtc  agtcagtct  agatttaca  3600
gcatttagg  gcctaggta  aagctgcta  tattctttt  aaagttata  ttatgactt  3660
caatgatag  aaactcctt  caattaaat  gcattttat  atattatgt  tgtacttca  3720
agtgttaaa  ataccctca  acgttattg  atttgatct  cacagaaag  gcattttaa  3780
cagtactct  ggtgcaata  ataatatgt  gaaatttaa  tcctccaat  ccagcatat  3840
cagtgagtt  tgacagtgt  tttatgtgg  atgtttaag  atatacaat  gtactttat  3900
taaattggt  cttgttctt  ttaaatgtg  catgaaata  ttgtgctgc  acattatac  3960
ggaaattaa  aggggaaaa  ggaagagct  ttggctccc  tgaggttct  ctagtggtg  4020
taggagtgg  tacaactga  cttttagta  ccatttaac  gtatgtaaa  ttggtttct  4080
attaaaaaa  aatttcttt  tcc  4103



<210> 455
<211> 568
<212> PRT
<213> Homo sapiens
<308> P49281
<400> 455

Met Val Leu Gly Pro Glu Gln Lys Met Ser Asp Asp Ser Val Ser Gly 
  1               5                  10                  15
Asp His Gly Glu Ser Ala Ser Leu Gly Asn Ile Asn Pro Ala Tyr Ser 
             20                  25                  30
Asn Pro Ser Leu Ser Gln Ser Pro Gly Asp Ser Glu Glu Tyr Phe Ala 
         35                  40                  45
Thr Tyr Phe Asn Glu Lys Ile Ser Ile Pro Glu Glu Glu Tyr Ser Cys 
     50                  55                  60
Phe Ser Phe Arg Lys Leu Trp Ala Phe Thr Gly Pro Gly Phe Leu Met 
 65                  70                  75                  80
Ser Ile Ala Tyr Leu Asp Pro Gly Asn Ile Glu Ser Asp Leu Gln Ser 
                 85                  90                  95
Gly Ala Val Ala Gly Phe Lys Leu Leu Trp Ile Leu Leu Leu Ala Thr 
             100                105                110
Leu Val Gly Leu Leu Leu Gln Arg Leu Ala Ala Arg Leu Gly Val Val 
         115                120                125
Thr Gly Leu His Leu Ala Glu Val Cys His Arg Gln Tyr Pro Lys Val 
     130                135                140
Pro Arg Val Ile Leu Trp Leu Met Val Glu Leu Ala Ile Ile Gly Ser 
 145                150                155                160
Asp Met Gln Glu Val Ile Gly Ser Ala Ile Ala Ile Asn Leu Leu Ser 
                 165                170                175
Val Gly Arg Ile Pro Leu Trp Gly Gly Val Leu Ile Thr Ile Ala Asp 
             180                185                190
Thr Phe Val Phe Leu Phe Leu Asp Lys Tyr Gly Leu Arg Lys Leu Glu 
         195                200                205
Ala Phe Phe Gly Phe Leu Ile Thr Ile Met Ala Leu Thr Phe Gly Tyr 
     210                215                220
Glu Tyr Val Thr Val Lys Pro Ser Gln Ser Gln Val Leu Lys Gly Met 
 225                230                235                240
Phe Val Pro Ser Cys Ser Gly Cys Arg Thr Pro Gln Ile Glu Gln Ala 
                 245                250                255
Val Gly Ile Val Gly Ala Val Ile Met Pro His Asn Met Tyr Leu His 
             260                265                270
Ser Ala Leu Val Lys Ser Arg Gln Val Asn Arg Asn Asn Lys Gln Glu 
         275                280                285
Val Arg Glu Ala Asn Lys Tyr Phe Phe Ile Glu Ser Cys Ile Ala Leu 
     290                295                300
Phe Val Ser Phe Ile Ile Asn Val Phe Val Val Ser Val Phe Ala Glu 
 305                310                315                320
Ala Phe Phe Gly Lys Thr Asn Glu Gln Val Val Glu Val Cys Thr Asn 
                 325                330                335
Thr Ser Ser Pro His Ala Gly Leu Phe Pro Lys Asp Asn Ser Thr Leu 
             340                345                350
Ala Val Asp Ile Tyr Lys Gly Gly Val Val Leu Gly Cys Tyr Phe Gly 
         355                360                365
Pro Ala Ala Leu Tyr Ile Trp Ala Val Gly Ile Leu Ala Ala Gly Gln 
     370                375                380
Ser Ser Thr Met Thr Gly Thr Tyr Ser Gly Gln Phe Val Met Glu Gly 
 385                390                395                400
Phe Leu Asn Leu Lys Trp Ser Arg Phe Ala Arg Val Val Leu Thr Arg 
                 405                410                415
Ser Ile Ala Ile Ile Pro Thr Leu Leu Val Ala Val Phe Gln Asp Val 
             420                425                430
Glu His Leu Thr Gly Met Asn Asp Phe Leu Asn Val Leu Gln Ser Leu 
         435                440                445
Gln Leu Pro Phe Ala Leu Ile Pro Ile Leu Thr Phe Thr Ser Leu Arg 
     450                455                460
Pro Val Met Ser Asp Phe Ala Asn Gly Leu Gly Trp Arg Ile Ala Gly 
 465                470                475                480
Gly Ile Leu Val Leu Ile Ile Cys Ser Ile Asn Met Tyr Phe Val Val 
                 485                490                495
Val Tyr Val Arg Asp Leu Gly His Val Ala Leu Tyr Val Val Ala Ala 
             500                505                510
Val Val Ser Val Ala Tyr Leu Gly Phe Val Phe Tyr Leu Gly Trp Gln 
         515                520                525
Cys Leu Ile Ala Leu Gly Met Ser Phe Leu Asp Cys Gly His Thr Cys 
     530                535                540
His Leu Gly Leu Thr Ala Gln Pro Glu Leu Tyr Leu Leu Asn Thr Met 
 545                550                555                560
Asp Ala Asp Ser Leu Val Ser Arg 
                 565



<210> 456
<211> 1219
<212> DNA
<213> Rattus norvegicus
<308> AF008554
<400> 456

aattgagga  gtcagaagg  ttcgcccgg  cgccgagag  gacaagcga  catggcctc  60
ccgaggtgg  tctggtgtg  gtgtgcgac  gcagcggtc  cactgctgc  cgtttccaa  120
gttccttcg  cctctgccc  aagaaagaa  gagaaggtt  tagtggaga  ggtcattca  180
ctgatggaa  ggaccaatc  aagaccagt  ataagaatg  atggagaca  gttccgtcc  240
cttgttaaa  caccaccaa  aaattactc  gttattgtc  tgtttactg  tctccaact  300
catagacaa  gtgtcgttt  caagcaagc  gatgaagaa  tccagattt  ggcaaattt  360
tggcgatac  ccagtgcat  taccaaccg  atatttttt  ccatggtgg  ttttgatga  420
ggctctgat  tatttcaaa  gctaaacat  aattcagct  caactttca  caactttcc  480
ccaaaagga  aacccaaaa  ggctgatac  tatgagttg  aggtgcgag  gttttcagc  540
gaacagatt  cccggtgga  cgcagacag  actgacgtc  acattagag  aatcagacc  600
ccaaattat  ctggacctc  aatgttggg  ttgcttctt  ctgttattg  tggacttgt  660
tatctgcga  gaagtaata  ggaattcct  tttaataaa  ccggatggg  ttttgcagc  720
ttgtgtttt  tacttgcaa  gacatctgg  caaatgtgg  accatataa  aggaccacc  780
tatgctcat  agaatcccc  tacaggaca  gtgaattat  tccacggaa  cagccaagc  840
cagtttgta  ctgaaaccc  cattgttct  ctcttcaat  gtggggtta  cttaggtat  900
gtgctttta  gtgaagctg  tgcctctga  atggatatt  ggaagcgaa  gatgatgtg  960
attgctggg  ttggacttg  tgtgttatt  ttcagttgg  tgctgtcca  ctttcgatc  1020
aaataccat  gctatccat  cagctttct  atgagttaa  gaggattcc  gagaaacat  1080
gacaccggt  atggaaact  aaaaataaa  cctgttggg  gttggagaa  gcactcaag  1140
tttttctta  cccttgggc  aggaacgac  tataacaat  accaagtcc  gggccttaa  1200
gaaaggaac  gaggtttgg  1219



<210> 457
<211> 335
<212> PRT
<213> Rattus norvegicus
<308> O35777
<400> 457

Met Ala Ser Pro Arg Trp Leu Trp Cys Val Cys Ala Thr Ala Ala Val 
  1               5                  10                  15
Thr Leu Leu Leu Val Ser Lys Val Pro Ser Ala Ser Ala Gln Arg Lys 
             20                  25                  30
Lys Glu Lys Val Leu Val Glu Lys Val Ile Gln Leu Met Glu Trp Thr 
         35                  40                  45
Asn Gln Arg Pro Val Ile Arg Met Asn Gly Asp Lys Phe Arg Pro Leu 
     50                  55                  60
Val Lys Ala Pro Pro Arg Asn Tyr Ser Val Ile Val Met Phe Thr Ala 
 65                  70                  75                  80
Leu Gln Leu His Arg Gln Cys Val Val Cys Lys Gln Ala Asp Glu Glu 
                 85                  90                  95
Phe Gln Ile Leu Ala Asn Phe Trp Arg Tyr Ser Ser Ala Phe Thr Asn 
             100                105                110
Arg Ile Phe Phe Ala Met Val Asp Phe Asp Glu Gly Ser Asp Val Phe 
         115                120                125
Gln Met Leu Asn Met Asn Ser Ala Pro Thr Phe Ile Asn Phe Pro Pro 
     130                135                140
Lys Gly Lys Pro Lys Arg Ala Asp Thr Tyr Glu Leu Gln Val Arg Gly 
 145                150                155                160
Phe Ser Ala Glu Gln Ile Ala Arg Trp Ile Ala Asp Arg Thr Asp Val 
                 165                170                175
Asn Ile Arg Val Ile Arg Pro Pro Asn Tyr Ala Gly Pro Leu Met Leu 
             180                185                190
Gly Leu Leu Leu Ala Val Ile Gly Gly Leu Val Tyr Leu Arg Arg Ser 
         195                200                205
Asn Met Glu Phe Leu Phe Asn Lys Thr Gly Trp Ala Phe Ala Ala Leu 
     210                215                220
Cys Phe Val Leu Ala Met Thr Ser Gly Gln Met Trp Asn His Ile Arg 
 225                230                235                240
Gly Pro Pro Tyr Ala His Lys Asn Pro His Thr Gly His Val Asn Tyr 
                 245                250                255
Ile His Gly Ser Ser Gln Ala Gln Phe Val Ala Glu Thr His Ile Val 
             260                265                270
Leu Leu Phe Asn Gly Gly Val Thr Leu Gly Met Val Leu Leu Cys Glu 
         275                280                285
Ala Ala Ala Ser Asp Met Asp Ile Gly Lys Arg Arg Met Met Cys Ile 
     290                295                300
Ala Gly Ile Gly Leu Val Val Leu Phe Phe Ser Trp Met Leu Ser Ile 
 305                310                315                320
Phe Arg Ser Lys Tyr His Gly Tyr Pro Tyr Ser Phe Leu Met Ser 
                 325                330                335



<210> 458
<211> 3015
<212> DNA
<213> Homo sapiens
<308> AK027632
<400> 458

cattcacca  caggatatt  tttgccatg  tggattttg  tgaaggctc  gatgtattt  60
agatgctaa  catgaattc  gctccaact  tcatcaact  tcctgcaaa  gggaaaccc  120
aacggggtg  tacatatga  ttacaggtg  ggggttttt  agctgagca  attgcccgg  180
ggatcgccg  cagaactga  gtcaatatt  gagtgatta  acccccaaa  tatgctggt  240
cccttatgt  gggattgct  ttggctgtt  ttggtggac  tgtgtatct  cgaagaagt  300
atatggaat  tctctttaa  aaaactgga  gggcttttg  agctttgtg  tttgtgctt  360
ctatgacat  tggtcaaat  tggaaccat  taagaggac  accatatgc  cataagaat  420
cccacacgg  acatgtgaa  tatatccat  gaagcagtc  agcccagtt  gtagctgaa  480
cacacattg  tcttctgtt  aatggtgga  ttaccttag  aatggtgct  ttatgtgaa  540
ctgctacct  tgacatgga  attggaaag  gaaagataa  gtgtgtggc  ggtattgga  600
ttgttgtat  attcttcag  tggatgctc  ctattttta  atctaaata  catggctac  660
catacagct  tctgatgag  taaaaaggt  ccagagata  atagacact  gagtactgg  720
aattgaaaa  cgaaaatcg  gtgtgtttg  aaagaagaa  gcaacttgt  tattttgta  780
tacctcttt  tttcaagtg  tttaaatag  taatcattt  accaaagaa  atgtgtagt  840
ccttaacaa  caatcctct  tcaaaatct  aggtatttg  aaataatta  cctcttaac  900
ttctcttcc  agtgaactt  atggaacat  taatttagt  caattaagt  tattataaa  960
attgtaaaa  tactacttt  ttttagtta  aacaaagct  aaaactact  tagttaact  1020
ggtcatctg  ttttatatt  ccttatcca  agatgggga  agtaagtcc  gaccaggtg  1080
tcccacata  gcctgttac  gataactac  ttaggaatt  attcttagc  tcttcatct  1140
tgtgtggat  tgtatactt  acgcatctt  ccttttgag  agagaaatt  tgtgtgtca  1200
gcggtcttc  gaaaatgga  caccattct  cagagcaca  gtctagccc  cagcaagac  1260
gttgtttct  ctcctcctt  catatttcc  actgaaata  agtgctgtc  atgattgtt  1320
ttgttttgt  gtttttttg  gacgctact  cgctccagc  tgagtgata  agtgagact  1380
tgtctcaaa  aaaagtatc  ctaaataca  gattataat  tctgcttga  tatggtgtt  1440
actaccttg  atttagaaa  atttcagat  cattccatc  ccttagttt  cttttaagg  1500
gacccatct  tgataaaaa  atagcttag  gctaaaatc  gtgtaactt  tacatggcc  1560
aaaatgttt  tacaaatta  agtttgtca  ttattccat  tgtacctaa  agaaaaata  1620
gctcagtta  aaaaggact  cctggccag  cgcagtgac  tacgcctgt  atctcagca  1680
tttgggagg  caaggcagg  agatcacga  gtcaggagt  cgagaccat  ctggccaac  1740
tggtgaaac  ccgtctcta  taaaaatat  aaaattagc  gggtgtggt  gcaggagcc  1800
gtaatccca  ctacacagg  ggctgaggc  cgagaatca  ttgaactca  gagatggag  1860
tttcagtga  ccaagatca  accactgca  tccagcctg  caacagagc  agactccat  1920
tcaaaaaaa  aaaaaaagt  agaaagaaa  ggactccct  agaatggga  agaaaaatc  1980
taaaatatt  agctgatgc  tgtatatag  aattaagcg  ttctcgaaa  ctgttctat  2040
ttttgctgt  attttagtc  ttattctct  cctttaggt  gagaaacaa  gtaccaatt  2100
gaagggatt  tttttattt  gtcttttgg  ttctgtcag  agaaataac  atatgtgct  2160
accaaattt  tgtgaagaa  gttttcatg  ttatcatta  atctaacta  aacctcccc  2220
atagttatg  agagtaacc  gaaatgcca  tattgtgga  ataggataa  tgtaattgt  2280
aaaaaataa  tttaaggaa  tcttacaag  attacatta  aaagatact  tgactgcca  2340
ctgccattt  ccttctaat  accctgcca  gtggtttgc  gaaagagat  gatatagta  2400
cctcagaag  aatatttta  gtgggtttt  tgtttttcg  tactagatt  catggatga  2460
gggatatgg  tgacctttt  ctttttaat  gagcagcca  tttttgtta  ttactcact  2520
gtaaattgt  agattctga  ttccttacc  gctattctt  tacttgtct  aggccaaat  2580
tatgctgtg  ttcttatga  acttgtatg  agatgccct  atttgtaca  attgaccac  2640
ggaatacta  tgccatgta  tctgtatag  tccagataa  ttgtcatga  cattgacag  2700
atgacaatt  tttgtattt  ctttttctc  ctttaagag  acattcttc  gtaaggaga  2760
aggcagcat  ctggctaaa  tgtgtagaa  gtaatttac  acacttata  aatagtgtg  2820
cttttgtga  aattttgaa  tagctttca  atgaagtgc  ttaagtaga  tcttcattt  2880
cttttctgg  aatggttta  atatcattt  ttatgcatt  ttaagatac  gttcagaat  2940
acacattgt  gtggcaaag  taaccaaat  tctggctgt  tgctttttg  ccatatcaa  3000
aaactttta  aatct  3015



<210> 459
<211> 348
<212> PRT
<213> Homo sapiens
<308> AAB18374
<400> 459

Met Gly Ala Arg Gly Ala Pro Ser Arg Arg Arg Gln Ala Gly Arg Arg 
  1               5                  10                  15
Leu Arg Tyr Leu Pro Thr Gly Ser Phe Pro Phe Leu Leu Leu Leu Leu 
             20                  25                  30
Leu Leu Cys Ile Gln Leu Gly Gly Gly Gln Lys Lys Lys Glu Asn Leu 
         35                  40                  45
Leu Ala Glu Lys Val Glu Gln Leu Met Glu Trp Ser Ser Arg Arg Ser 
     50                  55                  60
Ile Phe Arg Met Asn Gly Asp Lys Phe Arg Lys Phe Ile Lys Ala Pro 
 65                  70                  75                  80
Pro Arg Asn Tyr Ser Met Ile Val Met Phe Thr Ala Leu Gln Pro Gln 
                 85                  90                  95
Arg Gln Cys Ser Val Cys Arg Gln Ala Asn Glu Glu Tyr Gln Ile Leu 
             100                105                110
Ala Asn Ser Trp Arg Tyr Ser Ser Ala Phe Cys Asn Lys Leu Phe Phe 
         115                120                125
Ser Met Val Asp Tyr Asp Glu Gly Thr Asp Val Phe Gln Gln Leu Asn 
     130                135                140
Met Asn Ser Ala Pro Thr Phe Met His Phe Pro Pro Lys Gly Arg Pro 
 145                150                155                160
Lys Arg Ala Asp Thr Phe Asp Leu Gln Arg Ile Gly Phe Ala Ala Glu 
                 165                170                175
Gln Leu Ala Lys Trp Ile Ala Asp Arg Thr Asp Val His Ile Arg Val 
             180                185                190
Phe Arg Pro Pro Asn Tyr Ser Gly Thr Ile Ala Leu Ala Leu Leu Val 
         195                200                205
Ser Leu Val Gly Gly Leu Leu Tyr Leu Arg Arg Asn Asn Leu Glu Phe 
     210                215                220
Ile Tyr Asn Lys Thr Gly Trp Ala Met Val Ser Leu Cys Ile Val Phe 
 225                230                235                240
Ala Met Thr Ser Gly Gln Met Trp Asn His Ile Arg Gly Pro Pro Tyr 
                 245                250                255
Ala His Lys Asn Pro His Asn Gly Gln Val Ser Tyr Ile His Gly Ser 
             260                265                270
Ser Gln Ala Gln Phe Val Ala Glu Ser His Ile Ile Leu Val Leu Asn 
         275                280                285
Ala Ala Ile Thr Met Gly Met Val Leu Leu Asn Glu Ala Ala Thr Ser 
     290                295                300
Lys Gly Asp Val Gly Lys Arg Arg Ile Ile Cys Leu Val Gly Leu Gly 
 305                310                315                320
Leu Val Val Phe Phe Phe Ser Phe Leu Leu Ser Ile Phe Arg Ser Lys 
                 325                330                335
Tyr His Gly Tyr Pro Tyr Ser Asp Leu Asp Phe Glu 
             340                345



<210> 460
<211> 1219
<212> DNA
<213> Rattus norvegicus
<308> AF008554
<400> 460

aattgagga  gtcagaagg  ttcgcccgg  cgccgagag  gacaagcga  catggcctc  60
ccgaggtgg  tctggtgtg  gtgtgcgac  gcagcggtc  cactgctgc  cgtttccaa  120
gttccttcg  cctctgccc  aagaaagaa  gagaaggtt  tagtggaga  ggtcattca  180
ctgatggaa  ggaccaatc  aagaccagt  ataagaatg  atggagaca  gttccgtcc  240
cttgttaaa  caccaccaa  aaattactc  gttattgtc  tgtttactg  tctccaact  300
catagacaa  gtgtcgttt  caagcaagc  gatgaagaa  tccagattt  ggcaaattt  360
tggcgatac  ccagtgcat  taccaaccg  atatttttt  ccatggtgg  ttttgatga  420
ggctctgat  tatttcaaa  gctaaacat  aattcagct  caactttca  caactttcc  480
ccaaaagga  aacccaaaa  ggctgatac  tatgagttg  aggtgcgag  gttttcagc  540
gaacagatt  cccggtgga  cgcagacag  actgacgtc  acattagag  aatcagacc  600
ccaaattat  ctggacctc  aatgttggg  ttgcttctt  ctgttattg  tggacttgt  660
tatctgcga  gaagtaata  ggaattcct  tttaataaa  ccggatggg  ttttgcagc  720
ttgtgtttt  tacttgcaa  gacatctgg  caaatgtgg  accatataa  aggaccacc  780
tatgctcat  agaatcccc  tacaggaca  gtgaattat  tccacggaa  cagccaagc  840
cagtttgta  ctgaaaccc  cattgttct  ctcttcaat  gtggggtta  cttaggtat  900
gtgctttta  gtgaagctg  tgcctctga  atggatatt  ggaagcgaa  gatgatgtg  960
attgctggg  ttggacttg  tgtgttatt  ttcagttgg  tgctgtcca  ctttcgatc  1020
aaataccat  gctatccat  cagctttct  atgagttaa  gaggattcc  gagaaacat  1080
gacaccggt  atggaaact  aaaaataaa  cctgttggg  gttggagaa  gcactcaag  1140
tttttctta  cccttgggc  aggaacgac  tataacaat  accaagtcc  gggccttaa  1200
gaaaggaac  gaggtttgg  1219



<210> 461
<211> 335
<212> PRT
<213> Rattus norvegicus
<308> O35777
<400> 461

Met Ala Ser Pro Arg Trp Leu Trp Cys Val Cys Ala Thr Ala Ala Val 
  1               5                  10                  15
Thr Leu Leu Leu Val Ser Lys Val Pro Ser Ala Ser Ala Gln Arg Lys 
             20                  25                  30
Lys Glu Lys Val Leu Val Glu Lys Val Ile Gln Leu Met Glu Trp Thr 
         35                  40                  45
Asn Gln Arg Pro Val Ile Arg Met Asn Gly Asp Lys Phe Arg Pro Leu 
     50                  55                  60
Val Lys Ala Pro Pro Arg Asn Tyr Ser Val Ile Val Met Phe Thr Ala 
 65                  70                  75                  80
Leu Gln Leu His Arg Gln Cys Val Val Cys Lys Gln Ala Asp Glu Glu 
                 85                  90                  95
Phe Gln Ile Leu Ala Asn Phe Trp Arg Tyr Ser Ser Ala Phe Thr Asn 
             100                105                110
Arg Ile Phe Phe Ala Met Val Asp Phe Asp Glu Gly Ser Asp Val Phe 
         115                120                125
Gln Met Leu Asn Met Asn Ser Ala Pro Thr Phe Ile Asn Phe Pro Pro 
     130                135                140
Lys Gly Lys Pro Lys Arg Ala Asp Thr Tyr Glu Leu Gln Val Arg Gly 
 145                150                155                160
Phe Ser Ala Glu Gln Ile Ala Arg Trp Ile Ala Asp Arg Thr Asp Val 
                 165                170                175
Asn Ile Arg Val Ile Arg Pro Pro Asn Tyr Ala Gly Pro Leu Met Leu 
             180                185                190
Gly Leu Leu Leu Ala Val Ile Gly Gly Leu Val Tyr Leu Arg Arg Ser 
         195                200                205
Asn Met Glu Phe Leu Phe Asn Lys Thr Gly Trp Ala Phe Ala Ala Leu 
     210                215                220
Cys Phe Val Leu Ala Met Thr Ser Gly Gln Met Trp Asn His Ile Arg 
 225                230                235                240
Gly Pro Pro Tyr Ala His Lys Asn Pro His Thr Gly His Val Asn Tyr 
                 245                250                255
Ile His Gly Ser Ser Gln Ala Gln Phe Val Ala Glu Thr His Ile Val 
             260                265                270
Leu Leu Phe Asn Gly Gly Val Thr Leu Gly Met Val Leu Leu Cys Glu 
         275                280                285
Ala Ala Ala Ser Asp Met Asp Ile Gly Lys Arg Arg Met Met Cys Ile 
     290                295                300
Ala Gly Ile Gly Leu Val Val Leu Phe Phe Ser Trp Met Leu Ser Ile 
 305                310                315                320
Phe Arg Ser Lys Tyr His Gly Tyr Pro Tyr Ser Phe Leu Met Ser 
                 325                330                335



<210> 462
<211> 3015
<212> DNA
<213> Homo sapiens
<308> AK027632
<400> 462

cattcacca  caggatatt  tttgccatg  tggattttg  tgaaggctc  gatgtattt  60
agatgctaa  catgaattc  gctccaact  tcatcaact  tcctgcaaa  gggaaaccc  120
aacggggtg  tacatatga  ttacaggtg  ggggttttt  agctgagca  attgcccgg  180
ggatcgccg  cagaactga  gtcaatatt  gagtgatta  acccccaaa  tatgctggt  240
cccttatgt  gggattgct  ttggctgtt  ttggtggac  tgtgtatct  cgaagaagt  300
atatggaat  tctctttaa  aaaactgga  gggcttttg  agctttgtg  tttgtgctt  360
ctatgacat  tggtcaaat  tggaaccat  taagaggac  accatatgc  cataagaat  420
cccacacgg  acatgtgaa  tatatccat  gaagcagtc  agcccagtt  gtagctgaa  480
cacacattg  tcttctgtt  aatggtgga  ttaccttag  aatggtgct  ttatgtgaa  540
ctgctacct  tgacatgga  attggaaag  gaaagataa  gtgtgtggc  ggtattgga  600
ttgttgtat  attcttcag  tggatgctc  ctattttta  atctaaata  catggctac  660
catacagct  tctgatgag  taaaaaggt  ccagagata  atagacact  gagtactgg  720
aattgaaaa  cgaaaatcg  gtgtgtttg  aaagaagaa  gcaacttgt  tattttgta  780
tacctcttt  tttcaagtg  tttaaatag  taatcattt  accaaagaa  atgtgtagt  840
ccttaacaa  caatcctct  tcaaaatct  aggtatttg  aaataatta  cctcttaac  900
ttctcttcc  agtgaactt  atggaacat  taatttagt  caattaagt  tattataaa  960
attgtaaaa  tactacttt  ttttagtta  aacaaagct  aaaactact  tagttaact  1020
ggtcatctg  ttttatatt  ccttatcca  agatgggga  agtaagtcc  gaccaggtg  1080
tcccacata  gcctgttac  gataactac  ttaggaatt  attcttagc  tcttcatct  1140
tgtgtggat  tgtatactt  acgcatctt  ccttttgag  agagaaatt  tgtgtgtca  1200
gcggtcttc  gaaaatgga  caccattct  cagagcaca  gtctagccc  cagcaagac  1260
gttgtttct  ctcctcctt  catatttcc  actgaaata  agtgctgtc  atgattgtt  1320
ttgttttgt  gtttttttg  gacgctact  cgctccagc  tgagtgata  agtgagact  1380
tgtctcaaa  aaaagtatc  ctaaataca  gattataat  tctgcttga  tatggtgtt  1440
actaccttg  atttagaaa  atttcagat  cattccatc  ccttagttt  cttttaagg  1500
gacccatct  tgataaaaa  atagcttag  gctaaaatc  gtgtaactt  tacatggcc  1560
aaaatgttt  tacaaatta  agtttgtca  ttattccat  tgtacctaa  agaaaaata  1620
gctcagtta  aaaaggact  cctggccag  cgcagtgac  tacgcctgt  atctcagca  1680
tttgggagg  caaggcagg  agatcacga  gtcaggagt  cgagaccat  ctggccaac  1740
tggtgaaac  ccgtctcta  taaaaatat  aaaattagc  gggtgtggt  gcaggagcc  1800
gtaatccca  ctacacagg  ggctgaggc  cgagaatca  ttgaactca  gagatggag  1860
tttcagtga  ccaagatca  accactgca  tccagcctg  caacagagc  agactccat  1920
tcaaaaaaa  aaaaaaagt  agaaagaaa  ggactccct  agaatggga  agaaaaatc  1980
taaaatatt  agctgatgc  tgtatatag  aattaagcg  ttctcgaaa  ctgttctat  2040
ttttgctgt  attttagtc  ttattctct  cctttaggt  gagaaacaa  gtaccaatt  2100
gaagggatt  tttttattt  gtcttttgg  ttctgtcag  agaaataac  atatgtgct  2160
accaaattt  tgtgaagaa  gttttcatg  ttatcatta  atctaacta  aacctcccc  2220
atagttatg  agagtaacc  gaaatgcca  tattgtgga  ataggataa  tgtaattgt  2280
aaaaaataa  tttaaggaa  tcttacaag  attacatta  aaagatact  tgactgcca  2340
ctgccattt  ccttctaat  accctgcca  gtggtttgc  gaaagagat  gatatagta  2400
cctcagaag  aatatttta  gtgggtttt  tgtttttcg  tactagatt  catggatga  2460
gggatatgg  tgacctttt  ctttttaat  gagcagcca  tttttgtta  ttactcact  2520
gtaaattgt  agattctga  ttccttacc  gctattctt  tacttgtct  aggccaaat  2580
tatgctgtg  ttcttatga  acttgtatg  agatgccct  atttgtaca  attgaccac  2640
ggaatacta  tgccatgta  tctgtatag  tccagataa  ttgtcatga  cattgacag  2700
atgacaatt  tttgtattt  ctttttctc  ctttaagag  acattcttc  gtaaggaga  2760
aggcagcat  ctggctaaa  tgtgtagaa  gtaatttac  acacttata  aatagtgtg  2820
cttttgtga  aattttgaa  tagctttca  atgaagtgc  ttaagtaga  tcttcattt  2880
cttttctgg  aatggttta  atatcattt  ttatgcatt  ttaagatac  gttcagaat  2940
acacattgt  gtggcaaag  taaccaaat  tctggctgt  tgctttttg  ccatatcaa  3000
aaactttta  aatct  3015



<210> 463
<211> 348
<212> PRT
<213> Homo sapiens
<308> AAB18374
<400> 463

Met Gly Ala Arg Gly Ala Pro Ser Arg Arg Arg Gln Ala Gly Arg Arg 
  1               5                  10                  15
Leu Arg Tyr Leu Pro Thr Gly Ser Phe Pro Phe Leu Leu Leu Leu Leu 
             20                  25                  30
Leu Leu Cys Ile Gln Leu Gly Gly Gly Gln Lys Lys Lys Glu Asn Leu 
         35                  40                  45
Leu Ala Glu Lys Val Glu Gln Leu Met Glu Trp Ser Ser Arg Arg Ser 
     50                  55                  60
Ile Phe Arg Met Asn Gly Asp Lys Phe Arg Lys Phe Ile Lys Ala Pro 
 65                  70                  75                  80
Pro Arg Asn Tyr Ser Met Ile Val Met Phe Thr Ala Leu Gln Pro Gln 
                 85                  90                  95
Arg Gln Cys Ser Val Cys Arg Gln Ala Asn Glu Glu Tyr Gln Ile Leu 
             100                105                110
Ala Asn Ser Trp Arg Tyr Ser Ser Ala Phe Cys Asn Lys Leu Phe Phe 
         115                120                125
Ser Met Val Asp Tyr Asp Glu Gly Thr Asp Val Phe Gln Gln Leu Asn 
     130                135                140
Met Asn Ser Ala Pro Thr Phe Met His Phe Pro Pro Lys Gly Arg Pro 
 145                150                155                160
Lys Arg Ala Asp Thr Phe Asp Leu Gln Arg Ile Gly Phe Ala Ala Glu 
                 165                170                175
Gln Leu Ala Lys Trp Ile Ala Asp Arg Thr Asp Val His Ile Arg Val 
             180                185                190
Phe Arg Pro Pro Asn Tyr Ser Gly Thr Ile Ala Leu Ala Leu Leu Val 
         195                200                205
Ser Leu Val Gly Gly Leu Leu Tyr Leu Arg Arg Asn Asn Leu Glu Phe 
     210                215                220
Ile Tyr Asn Lys Thr Gly Trp Ala Met Val Ser Leu Cys Ile Val Phe 
 225                230                235                240
Ala Met Thr Ser Gly Gln Met Trp Asn His Ile Arg Gly Pro Pro Tyr 
                 245                250                255
Ala His Lys Asn Pro His Asn Gly Gln Val Ser Tyr Ile His Gly Ser 
             260                265                270
Ser Gln Ala Gln Phe Val Ala Glu Ser His Ile Ile Leu Val Leu Asn 
         275                280                285
Ala Ala Ile Thr Met Gly Met Val Leu Leu Asn Glu Ala Ala Thr Ser 
     290                295                300
Lys Gly Asp Val Gly Lys Arg Arg Ile Ile Cys Leu Val Gly Leu Gly 
 305                310                315                320
Leu Val Val Phe Phe Phe Ser Phe Leu Leu Ser Ile Phe Arg Ser Lys 
                 325                330                335
Tyr His Gly Tyr Pro Tyr Ser Asp Leu Asp Phe Glu 
             340                345



<210> 464
<211> 3101
<212> DNA
<213> Rattus norvegicus
<308> AF009329
<400> 464

tgtctacac  ataattcct  tgtctttga  ccagctcac  aatgtcact  tggttctga  60
tgtgggggt  ttggtgcag  ccctcccct  ccagtccct  ccgtcgagg  gcatggtgc  120
agtgctgcc  cagcctgga  acgcacaca  ccccccaaa  tctctccag  cgaccgtcc  180
acgatcaca  gacagaacc  tccaaatcg  aacggagga  acggacagc  attgaacat  240
gacgaagga  tccctcatt  gcaagagag  cagttactg  aacataggg  ttttatagg  300
ctggactat  cctctttgt  tatgtgtaa  cccaaaagg  gcttgaagc  agacgacac  360
aaggatacc  acaaattac  gcacagatt  atagaaaag  agagacgag  ccgaattaa  420
gaatgtatt  ctcagctga  agacttact  cctgaacat  tgaaattga  aacactggg  480
catctggag  aagcagtag  cttggaatt  actttgaag  acttaaaag  tttaacagc  540
ttaacggag  agcagcatc  gaagataat  gctttacag  atggggagc  ctctctgaa  600
tcgccggtc  aggccgact  ggatgcgtt  cactcgggg  ttcaaacct  cgccaaaga  660
gtcttgcaa  acctcgcgc  ctttgagag  tggacgccc  gggaaccgc  ctgcgcaca  720
ctcgtcagc  acctgcacg  cgtggctac  cagcttctg  cgccacagg  gaccccagg  780
aggggccct  ggcgcgcgc  ctgcagcgc  ggggctgca  ccgcctccg  ttccgagcg  840
gtcgcccgc  gcgtgccgg  catccagcg  actcagccc  gcacggagc  cgagcacga  900
acggacacc  acagcggct  tggaggcga  gcggagcag  gccgcgccg  cgtcaagca  960
gagccaccc  gggacccgt  gctgcgccc  agaggctga  gctggaggc  cgcggcgcg  1020
tcctgggcc  ggagcccgc  ctgctcggc  ctctcgtgg  gttgggcgg  ggtgcgccc  1080
tcgcgcagc  cgccgccgc  cccttctgc  tgcccttct  cctgctgtc  ccgtccgcc  1140
ccgcctacg  acagccctg  ctagacaag  gtggcctgg  caagtatct  taccccgcg  1200
cggccgcgc  cttcccgct  ctgtatccc  gcatccccg  agcagccgc  gctgccgcc  1260
ccgccgctt  cccttgctt  tcgtccgtg  tatcgccac  cccggagaa  gcaggttcg  1320
ccgctggtg  cccattcct  gcgcacgag  tggcgcccc  ggggtcgct  cgcccccag  1380
acgcgcata  ccgcaccca  ctgccgcac  ccgtgaacc  agagagctc  caggaagat  1440
ccacgcagc  ggccaagga  gccccctga  cccagcatt  cttccagaa  agggcaggg  1500
gctcctgag  agtcgccag  tttccaagt  caaacatcc  ctaaggcgt  ccagggagg  1560
agagtaaga  atgctctgc  cgacaggct  aggacaaaa  caggtgttt  gtgtatgtt  1620
ggagttcct  ttttgcccc  ttctcaccc  tctgccacc  caccctcta  cctttgaca  1680
tcccttccc  atccctgct  tcacagagc  tccctgaga  atactggtt  tcttaaatt  1740
ccctccctt  catttagtt  acgtcctct  tttccaaac  tagaccctg  ttcaggagt  1800
tgttgggtg  gagagccac  cggaaccag  tagagtgcc  ggtatcagg  ctccttgac  1860
caggcctgg  acagtagct  tgtcccctg  ctgtcccct  aggaggtga  ccataactg  1920
gggtctctg  aagttacat  gacgtgtca  tattttgta  tcttcagct  tttggaagg  1980
acctctttt  caaagaagt  aggatgcca  tgccctgtt  tgaggtggc  ggagtggtg  2040
ctttatacc  tgcacctgt  gggagaaac  gagagttgg  gccatcttc  ggcactgtg  2100
cagtgtggg  gctggaaga  ggagtttgg  gcccgtggc  cctttctcg  actttattg  2160
caaattgac  tcaacccct  tgtcccatg  ctcaactca  agatatatg  cataggtta  2220
atatttgtg  ttctgatcc  tcgttattt  atccatcat  gtcccaaat  tttgtaatg  2280
tactggggt  tggggtggg  tggggtgtt  aagtgctct  ggctggaaa  agacaagcc  2340
aaacctatt  attgtcgaa  tcttagatg  cagaagtgg  gagaggggc  tgtggtccc  2400
tgtgatggg  agtgctgtg  acatgtaga  ggccctgcc  gcctcgctc  ctcaagtct  2460
tatgtattt  tcgggagac  aaaccagac  ccagataat  aggaagaaa  ctttttaaa  2520
taaggcaaa  accgagacc  tgtctagat  tttttagtt  gttgccaag  tagcactga  2580
aaatctcac  tgaatgtta  ataaggagt  attcacaat  gtctagagt  aagaaagtt  2640
tctgggtct  tgagtgttc  ggtccgttt  ctgctgctg  tgctactgt  tgcctcaaa  2700
gctgtgttt  aacaacgtt  aacttctta  cctaccaag  cggccgtat  tacatagct  2760
ttaataccc  caactaatg  ctgacatgc  atttttgta  ggagaagat  cctgctagt  2820
atattttga  ttaaaatat  ttttggggc  gacttggtg  aatgtttgc  ctttggtca  2880
aatgcttct  ctgcttggt  caacgttac  ctgtcttaa  ttattaaac  aataaaaaa  2940
actatctgc  agaaaaacc  gctggttta  acaagttta  tatgtaaag  taagctaga  3000
actatcttt  tattctagt  ttttcagca  tccatatta  ctaaatatt  ccacactat  3060
ttgtgattt  aaagttctt  ctaaggaat  aaatcttta  a  3101



<210> 465
<211> 410
<212> PRT
<213> Rattus norvegicus
<308> O35779
<400> 465

Met Asp Glu Gly Ile Pro His Leu Gln Glu Arg Gln Leu Leu Glu His 
  1               5                  10                  15
Arg Asp Phe Ile Gly Leu Asp Tyr Ser Ser Leu Tyr Met Cys Lys Pro 
             20                  25                  30
Lys Arg Ser Leu Lys Arg Asp Asp Thr Lys Asp Thr Tyr Lys Leu Pro 
         35                  40                  45
His Arg Leu Ile Glu Lys Lys Arg Arg Asp Arg Ile Asn Glu Cys Ile 
     50                  55                  60
Ala Gln Leu Lys Asp Leu Leu Pro Glu His Leu Lys Leu Thr Thr Leu 
 65                  70                  75                  80
Gly His Leu Glu Lys Ala Val Val Leu Glu Leu Thr Leu Lys His Leu 
                 85                  90                  95
Lys Ala Leu Thr Ala Leu Thr Glu Gln Gln His Gln Lys Ile Ile Ala 
             100                105                110
Leu Gln Asn Gly Glu Arg Ser Leu Lys Ser Pro Val Gln Ala Asp Leu 
         115                120                125
Asp Ala Phe His Ser Gly Phe Gln Thr Cys Ala Lys Glu Val Leu Gln 
     130                135                140
Tyr Leu Ala Arg Phe Glu Ser Trp Thr Pro Arg Glu Pro Arg Cys Ala 
 145                150                155                160
Gln Leu Val Ser His Leu His Ala Val Ala Thr Gln Leu Leu Thr Pro 
                 165                170                175
Gln Val Thr Pro Gly Arg Gly Pro Gly Arg Ala Pro Cys Ser Ala Gly 
             180                185                190
Ala Ala Ala Ala Ser Gly Ser Glu Arg Val Ala Arg Cys Val Pro Val 
         195                200                205
Ile Gln Arg Thr Gln Pro Gly Thr Glu Pro Glu His Asp Thr Asp Thr 
     210                215                220
Asp Ser Gly Tyr Gly Gly Glu Ala Glu Gln Gly Arg Ala Ala Val Lys 
 225                230                235                240
Gln Glu Pro Pro Gly Asp Pro Ser Ala Ala Pro Lys Arg Leu Lys Leu 
                 245                250                255
Glu Ala Arg Gly Ala Leu Leu Gly Pro Glu Pro Ala Leu Leu Gly Ser 
             260                265                270
Leu Val Ala Leu Gly Gly Gly Ala Pro Phe Ala Gln Pro Ala Ala Ala 
         275                280                285
Pro Phe Cys Leu Pro Phe Tyr Leu Leu Ser Pro Ser Ala Ala Ala Tyr 
     290                295                300
Val Gln Pro Trp Leu Asp Lys Ser Gly Leu Asp Lys Tyr Leu Tyr Pro 
 305                310                315                320
Ala Ala Ala Ala Pro Phe Pro Leu Leu Tyr Pro Gly Ile Pro Ala Ala 
                 325                330                335
Ala Ala Ala Ala Ala Ala Ala Ala Phe Pro Cys Leu Ser Ser Val Leu 
             340                345                350
Ser Pro Pro Pro Glu Lys Ala Gly Ser Ala Ala Gly Ala Pro Phe Leu 
         355                360                365
Ala His Glu Val Ala Pro Pro Gly Ser Leu Arg Pro Gln His Ala His 
     370                375                380
Ser Arg Thr His Leu Pro His Ala Val Asn Pro Glu Ser Ser Gln Glu 
 385                390                395                400
Asp Ala Thr Gln Pro Ala Lys Asp Ala Pro 
                 405                410



<210> 466
<211> 3641
<212> DNA
<213> Homo sapiens
<308> NM_030762
<400> 466

ctgcactga  gagggagag  gagagagag  ctggagacg  acagatccc  ccaaggtct  60
ccaagccta  cgtcccaca  attattgta  agagcccca  aaatcgaaa  agaggaaac  120
aacagcagt  gaacatgga  gaaggaatt  ctcatttgc  agagagaca  ttactggaa  180
atagagatt  tataggact  gactattcc  ctttgtata  gtgtaaacc  aaaaggagc  240
tgaaacgag  cgacaccaa  gatacctac  aattaccgc  cagattaat  gaaaagaaa  300
gaagagacc  aattaatga  tgcattgct  agctgaaag  tttactgcc  gaacatctg  360
aattgacaa  tctgggaca  ctggagaaa  ctgtagtct  ggaattaac  ttgaaacac  420
taaaagctt  aaccgcctt  accgagcaa  agcatcaga  gataattgc  ttacagaat  480
gggagcgat  tctgaaatc  cccattcag  ccgacttgg  tgcgttcca  tcgggattt  540
aaacatgcg  caaagaagt  ttgcaatac  tctcccggt  tgagagctg  acacccagg  600
agccgcggt  tgtccagct  atcaaccac  tgcacgccg  ggccaccca  ttcttgccc  660
ccccgcagc  gttgactca  caggtccct  tgagcaaag  caccggcgc  ccctcggcc  720
ccgggtccg  ggccgcccc  tgcctggag  gcgcggggc  gaagctgga  cccctcgcc  780
actgcgtgc  cgtcatcca  cggactcag  ccagcgccg  gctcgccgc  gagaacgac  840
cggacaccg  cagcggcta  ggcggcgaa  ccgaggccc  gccggaccg  gagaaaggc  900
aaggcgcgg  ggcgagccg  gtcaccatc  agcaggagc  tcccgggga  gactcgccg  960
cgcccaaga  gatgaagct  gattcccgc  gcggcggca  cggcggcgg  ccggggggc  1020
gcgcggcgg  ggcggcagc  gcgcttctg  ggcccgacc  tgccgccgc  gccgcgctg  1080
tgagacccg  cgccgccct  ctcagctcg  tggtggcgt  cggcggagg  ggaggcgcg  1140
ccttcccgc  gcccgcggc  gccgcggcc  ccttctgcc  gcccttctg  ttcctctcg  1200
cttctgcag  tgccgccta  gtgcagccc  tcctggaca  gagcggcct  gagaagtat  1260
tgtacccgg  ggcggctgc  gccccgttc  cgctgctat  ccccggcat  cccgccccg  1320
cggcagccg  ggcagccgc  gccgccgct  ccgccgccg  cgccgcgtt  ccctgcctg  1380
cctcggtgt  gtcgccccc  cccgagaag  cgggcgccg  cgccgcgac  ctcctgccg  1440
acgaggtgg  gccccttgg  gcgccgcac  cccagcacc  gcacggccg  acccacctg  1500
ccttcgccg  gccccgcga  ccggggaac  cggagagct  tgctcagga  gatccctcg  1560
agccaggaa  ggaagctcc  tgaatcctt  cgtcccgaa  gacggaggt  caagcagag  1620
gagaagtta  aataccctt  aggaggttc  agcagagtg  gaagttaaa  tacccttaa  1680
gtctttaag  gaggaagtg  aatagatgc  cgacaggca  aaacaagaa  aacaaaaca  1740
gtgttatgt  tacattcgg  gttcctgtt  tgctcatcc  gcaccaccc  accctccac  1800
cactaacat  cctttcttc  ccccaccag  tgtaaaaga  cctatgcga  agacactgg  1860
tcttttttt  aatccccca  ataaatttt  ccccctttt  ggccatgtt  cattatctc  1920
taaaattgg  acctaattc  agaggaagt  agaagggtc  gttctgtgg  tgagctagg  1980
gaaccccgg  gtaggggaa  gatgttaac  cctttgacg  ctttggagt  gacatggaa  2040
agcaggtag  tgttatgta  agctagttc  caaagctgc  ctgcctgtt  taggaggcg  2100
tccacaaac  gattgaggc  ctttttaga  ttgaattta  tcttcagta  tttctaatg  2160
tcagctttc  aaaaggcat  tatttttca  agaagtgag  atgcagttt  tcacgttgc  2220
acctattct  aagtggttt  aatggtatc  cttagtaac  tgcactcgt  aaagaaaca  2280
ggagctggg  catcgtcag  actaagtca  ggaaggaga  ggatgagaa  gccagaatc  2340
ttcctagta  atttgctaa  actttattg  gaaattgac  atgaattaa  ggactcatc  2400
taatttctt  taagtccat  tatagatag  tatctatct  tacagattt  tatttatcc  2460
tagataggt  tctatacat  cacatctca  gtgcatcta  tcccactct  attaatcca  2520
catgttcct  aatttttgt  atcttactg  aaaaaaaag  gcactgaac  tcaaaacaa  2580
acaaaaaac  acaacaaca  aaaacaagt  caaactgat  tatcctata  tctgttaaa  2640
ttcaaaagt  aacgaaagc  tttaactgg  cagttttga  tgcaaatgc  gtaaagata  2700
agaatgaag  cctgtgagg  cttcctatc  ccaagtcta  gtattttct  gagaccaaa  2760
cagatacca  ataatcaca  agaaagctt  tttaataag  cttaaacca  gaccttgtc  2820
agatatttt  agtttgttg  caaggtagc  ctgtgagaa  tctcacttg  atgttatgt  2880
aggggtgag  cacaacagt  tgactatga  tgaggaaaa  atctgggtc  tttcgtcag  2940
ttggtgcat  tgctgctgc  gttgctact  tttgcctca  acgctgtgt  taaacaacg  3000
taaactctt  gcctacaag  tggctctta  gtacatagt  gttaataca  ccaattaat  3060
atgtctgac  tgctatttt  gtagggaga  aatatgtgc  aatgatatt  tgagttaaa  3120
tatcttttg  ggaggattt  ctgaaaagt  gcacttttg  tacaatgct  atgcttggt  3180
caagcttat  ctgtcttaa  ttattttaa  aaaattaaa  actgtctgt  agaaaccag  3240
tggtttaga  aagtttagt  tgtgacgat  aactagaaa  tacctttat  ttctagtat  3300
ttcagcact  cataaattc  attacctaa  tattgccac  ctattttgt  atttaaaaa  3360
tcttactaa  gaataaaaa  tttaatata  gatatgata  tgtctaata  ttaaaaaag  3420
cataatgga  gctcaatta  ttttaagat  tctataact  tagggatac  aatcactac  3480
gttctcaga  ttacacctt  tttttgtca  tggcttgat  tcacacatt  ccaatctct  3540
gcaagcctc  aggctctgg  tttgtctac  tgctcgttc  caatgtatc  taatgaaaa  3600
tgcaaaaga  aaacctacc  attaaaaaa  aaaaaaaaa  a  3641



<210> 467
<211> 482
<212> PRT
<213> Homo sapiens
<308> Q9C0J9
<400> 467

Met Asp Glu Gly Ile Pro His Leu Gln Glu Arg Gln Leu Leu Glu His 
  1               5                  10                  15
Arg Asp Phe Ile Gly Leu Asp Tyr Ser Ser Leu Tyr Met Cys Lys Pro 
             20                  25                  30
Lys Arg Ser Met Lys Arg Asp Asp Thr Lys Asp Thr Tyr Lys Leu Pro 
         35                  40                  45
His Arg Leu Ile Glu Lys Lys Arg Arg Asp Arg Ile Asn Glu Cys Ile 
     50                  55                  60
Ala Gln Leu Lys Asp Leu Leu Pro Glu His Leu Lys Leu Thr Thr Leu 
 65                  70                  75                  80
Gly His Leu Glu Lys Ala Val Val Leu Glu Leu Thr Leu Lys His Leu 
                 85                  90                  95
Lys Ala Leu Thr Ala Leu Thr Glu Gln Gln His Gln Lys Ile Ile Ala 
             100                105                110
Leu Gln Asn Gly Glu Arg Ser Leu Lys Ser Pro Ile Gln Ser Asp Leu 
         115                120                125
Asp Ala Phe His Ser Gly Phe Gln Thr Cys Ala Lys Glu Val Leu Gln 
     130                135                140
Tyr Leu Ser Arg Phe Glu Ser Trp Thr Pro Arg Glu Pro Arg Cys Val 
 145                150                155                160
Gln Leu Ile Asn His Leu His Ala Val Ala Thr Gln Phe Leu Pro Thr 
                 165                170                175
Pro Gln Leu Leu Thr Gln Gln Val Pro Leu Ser Lys Gly Thr Gly Ala 
             180                185                190
Pro Ser Ala Ala Gly Ser Ala Ala Ala Pro Cys Leu Glu Arg Ala Gly 
         195                200                205
Gln Lys Leu Glu Pro Leu Ala Tyr Cys Val Pro Val Ile Gln Arg Thr 
     210                215                220
Gln Pro Ser Ala Glu Leu Ala Ala Glu Asn Asp Thr Asp Thr Asp Ser 
 225                230                235                240
Gly Tyr Gly Gly Glu Ala Glu Ala Arg Pro Asp Arg Glu Lys Gly Lys 
                 245                250                255
Gly Ala Gly Ala Ser Arg Val Thr Ile Lys Gln Glu Pro Pro Gly Glu 
             260                265                270
Asp Ser Pro Ala Pro Lys Arg Met Lys Leu Asp Ser Arg Gly Gly Gly 
         275                280                285
Ser Gly Gly Gly Pro Gly Gly Gly Ala Ala Ala Ala Ala Ala Ala Leu 
     290                295                300
Leu Gly Pro Asp Pro Ala Ala Ala Ala Ala Leu Leu Arg Pro Asp Ala 
 305                310                315                320
Ala Leu Leu Ser Ser Leu Val Ala Phe Gly Gly Gly Gly Gly Ala Pro 
                 325                330                335
Phe Pro Gln Pro Ala Ala Ala Ala Ala Pro Phe Cys Leu Pro Phe Cys 
             340                345                350
Phe Leu Ser Pro Ser Ala Ala Ala Ala Tyr Val Gln Pro Phe Leu Asp 
         355                360                365
Lys Ser Gly Leu Glu Lys Tyr Leu Tyr Pro Ala Ala Ala Ala Ala Pro 
     370                375                380
Phe Pro Leu Leu Tyr Pro Gly Ile Pro Ala Pro Ala Ala Ala Ala Ala 
 385                390                395                400
Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Phe Pro Cys Leu Ser 
                 405                410                415
Ser Val Leu Ser Pro Pro Pro Glu Lys Ala Gly Ala Ala Ala Ala Thr 
             420                425                430
Leu Leu Pro His Glu Val Ala Pro Leu Gly Ala Pro His Pro Gln His 
         435                440                445
Pro His Gly Arg Thr His Leu Pro Phe Ala Gly Pro Arg Glu Pro Gly 
     450                455                460
Asn Pro Glu Ser Ser Ala Gln Glu Asp Pro Ser Gln Pro Gly Lys Glu 
 465                470                475                480
Ala Pro 
                 485



<210> 468
<211> 2388
<212> DNA
<213> Rattus norvegicus
<308> AF009330
<400> 468

ttccctccc  cctctccac  cgccccact  ctcattcac  tggctcgca  ggcgcagac  60
gccaggcga  cacacaccg  cagtctgtg  gcagagcgg  agccagaag  cgtggggga  120
acccggtca  gcacgcccc  aactgaagc  acacctcaa  gccgcagct  ctggcagcc  180
aggccattg  aagaagctc  ggctagctc  taggaacat  ccccttgag  ccctcggat  240
ctcccttcc  ggccagtcc  ctctcagac  ctctgctaa  tgcagacag  agcgcacag  300
ggcccctgc  cgccgcatc  tggagcgga  ccccagcgc  caaccacct  ctacctgcc  360
gcccaaaac  ccagggctg  agcacggag  cctgtcagg  atggatttt  cccacatgt  420
ccaagtgta  aagtccagg  ggggaataa  acggagcga  gacagcaag  aaacttaca  480
attgccgca  cggttgatt  agaaaaaga  acgtgaccg  attaacgag  gcattgccc  540
gctgaagga  ctcctaccc  aacatctca  acttactac  ttgggtcac  tggagaaag  600
agtggttct  gagctgacg  tgaagcacg  gaaagcatt  acaaaccta  ttgatcagc  660
gcagcagaa  atcatggcc  tgcagagcg  tttacaagc  ggtgatctg  cgggaaaga  720
tattgaggc  ggacaagaa  tgttctgct  cggtttcca  acctgtgcc  gggaggtac  780
tcagtacct  gccaagcat  aaaacacta  ggacctgaa  tcttcccag  ttgtcactc  840
tctccaccg  gtggtctct  aactcctgc  gggtagtgc  tccaggaaa  cattggact  900
agctcccaa  cccgtggac  tcaaagaga  gcccagctt  ctagccaag  gatcagaag  960
ccctgggaa  aactgtgtg  cagtcatcc  gaggacttt  gctccctcg  gcggggagc  1020
gagtggtag  gacacggac  cagacagtg  ctacggagg  gaattggag  agggtgact  1080
gcgcagtga  caaccctac  tcaagagcg  tcacggacg  aggttcacc  tgggagaac  1140
cgtcagcac  attaagcaa  aatctgaag  gccccccac  aaaaagagc  gaatgcagc  1200
ctcagatga  gaaggccac  tcgtgggca  tgacctgat  ggttcccca  ttcttgggc  1260
tcacccaca  cagcctccc  tttgcctgc  cttctatct  atcccacca  cggccactg  1320
ctatctgcc  atgctggag  aatgctggt  tccgacctc  gtgccactg  tatacccag  1380
cctcaacac  tcagcagca  ccctctcca  cttcatgaa  ccagacaag  tcccaactc  1440
cttgctcct  ccccagaga  tcccttctc  cttggcaca  tcgtccctt  actcttcag  1500
cttgctcca  gccctgaag  agatccctc  tttaaactt  gaaaccaaa  actaaactc  1560
tgagggcga  tctcctgct  ctttgcttt  cctttcccc  ctaattcca  gaccacaaa  1620
ggtttctgt  agtgcagag  gatcggccc  ccatgcaga  ccacagaga  gattcagaa  1680
gtgtgtgag  gtgagtgtg  gagtgcgcg  gcgtgtgct  gtatgtgtg  ttatagatg  1740
aggacatta  gttccttct  acacaggga  gatgtgaga  ggatggcct  acatcagat  1800
acaagaggt  tatagcaca  ctctgggct  ttccctacc  agagaagag  cccctttga  1860
acaaatcag  tggattttc  tatgcttca  aggcttgat  tgtgagtca  tccagtttg  1920
gacataggt  tgtctgtgg  tttgagaaa  ggtactttc  aaagagggc  ttccagagc  1980
cagctcaca  ccagctgtt  ggaccccac  cttctcctt  attgtggag  tgactcaca  2040
cagactgac  gtggtcaga  tgagctttc  gctaaggtg  tgaggtagc  aacactggc  2100
tgtctcggt  gtggtttgg  caaatttcc  caggtctct  cccccaacc  tgcctctga  2160
gaataaaga  aatgagtac  gttccttaa  tcaggcttt  gtgactagc  tactacgga  2220
ccgaaaatg  tcccctttg  acaagccga  ctgttatgg  atcacggtg  accagaccc  2280
ggtctgtgg  acctgtttg  ttgtttttt  ttttttttt  ttttagctc  catttctac  2340
gcatgcttt  caaggaacc  aaggagggt  tcagagatg  cccctcgt  2388



<210> 469
<211> 411
<212> PRT
<213> Rattus norvegicus
<308> O35780
<400> 469

Met Glu Arg Ile Pro Ser Ala Gln Pro Pro Pro Thr Cys Leu Pro Lys 
  1               5                  10                  15
Thr Pro Gly Leu Glu His Gly Asp Leu Ser Gly Met Asp Phe Ala His 
             20                  25                  30
Met Tyr Gln Val Tyr Lys Ser Arg Arg Gly Ile Lys Arg Ser Glu Asp 
         35                  40                  45
Ser Lys Glu Thr Tyr Lys Leu Pro His Arg Leu Ile Glu Lys Lys Arg 
     50                  55                  60
Arg Asp Arg Ile Asn Glu Cys Ile Ala Gln Leu Lys Asp Leu Leu Pro 
 65                  70                  75                  80
Glu His Leu Lys Leu Thr Thr Leu Gly His Leu Glu Lys Ala Val Val 
                 85                  90                  95
Leu Glu Leu Thr Leu Lys His Val Lys Ala Leu Thr Asn Leu Ile Asp 
             100                105                110
Gln Gln Gln Gln Lys Ile Met Ala Leu Gln Ser Gly Leu Gln Ala Gly 
         115                120                125
Asp Leu Ser Gly Lys Asn Ile Glu Ala Gly Gln Glu Met Phe Cys Ser 
     130                135                140
Gly Phe Gln Thr Cys Ala Arg Glu Val Leu Gln Tyr Leu Ala Lys His 
 145                150                155                160
Glu Asn Thr Arg Asp Leu Lys Ser Ser Gln Leu Val Thr His Leu His 
                 165                170                175
Arg Val Val Ser Glu Leu Leu Gln Gly Ser Ala Ser Arg Lys Pro Leu 
             180                185                190
Asp Ser Ala Pro Lys Pro Val Asp Phe Lys Glu Lys Pro Ser Phe Leu 
         195                200                205
Ala Lys Gly Ser Glu Gly Pro Gly Lys Asn Cys Val Pro Val Ile Gln 
     210                215                220
Arg Thr Phe Ala Pro Ser Gly Gly Glu Gln Ser Gly Ser Asp Thr Asp 
 225                230                235                240
Thr Asp Ser Gly Tyr Gly Gly Glu Leu Glu Lys Gly Asp Leu Arg Ser 
                 245                250                255
Glu Gln Pro Tyr Phe Lys Ser Asp His Gly Arg Arg Phe Thr Val Gly 
             260                265                270
Glu Arg Val Ser Thr Ile Lys Gln Glu Ser Glu Glu Pro Pro Thr Lys 
         275                280                285
Lys Ser Arg Met Gln Leu Ser Asp Glu Glu Gly His Phe Val Gly Ser 
     290                295                300
Asp Leu Met Gly Ser Pro Phe Leu Gly Pro His Pro His Gln Pro Pro 
 305                310                315                320
Phe Cys Leu Pro Phe Tyr Leu Ile Pro Pro Ser Ala Thr Ala Tyr Leu 
                 325                330                335
Pro Met Leu Glu Lys Cys Trp Tyr Pro Thr Ser Val Pro Leu Leu Tyr 
             340                345                350
Pro Gly Leu Asn Thr Ser Ala Ala Ala Leu Ser Ser Phe Met Asn Pro 
         355                360                365
Asp Lys Ile Pro Thr Pro Leu Leu Leu Pro Gln Arg Leu Pro Ser Pro 
     370                375                380
Leu Ala His Ser Ser Leu Asp Ser Ser Ala Leu Leu Gln Ala Leu Lys 
 385                390                395                400
Gln Ile Pro Pro Leu Asn Leu Glu Thr Lys Asp 
                 405                410



<210> 470
<211> 2922
<212> DNA
<213> Homo sapiens
<308> NM_003670
<400> 470

ggacaccgg  ccatgcacg  ccccaactg  agctgcatc  caaagccga  gattccagc  60
gcccagggg  tttcaaaga  ctcagactc  gaggaacat  tgcggagag  cccccgaag  120
cctctccag  gcagtcctc  tccagacgc  ccgctagtg  agacaggag  gcgcagtgg  180
cccggctcg  cgcgccatg  agcggatcc  cagcgcgca  ccacccccc  cctgcctgc  240
caaagcacc  ggactggag  acggagacc  accagggat  taccctgcc  acatgtacc  300
agtgtacaa  tcaagacgg  gaataaagc  gagcgagga  agcaaggag  cctacaaat  360
gccgcaccg  ctcatcgag  aaaagagac  tgaccggat  aacgagtgc  tcgcccagc  420
gaaggatct  ctacccgaa  atctcaaac  tacaacttt  ggtcacttg  aaaaagcag  480
ggttcttga  cttaccttg  agcatgtga  agcactaac  aacctaatt  atcagcagc  540
gcagaaaat  attgccctg  agagtggtt  acaagctgg  gagctgtca  ggagaaatg  600
cgaaacagg  caagagatg  tctgctcag  tttccagac  tgtgcccgg  aggtgcttc  660
gtatctggc  aagcacgag  acactcggg  cctgaagtc  tcgcagctt  tcacccacc  720
ccaccgggt  gtctcggag  tgctgcagg  tggtacctc  aggaagcca  cagacccag  780
tcccaaagt  atggacttc  aggaaaaac  cagctctcc  gccaaaggt  cggaaggtc  840
tgggaaaaa  tgcgtgcca  tcatccagc  gactttcgc  cactcgagt  gggagcaga  900
cggcagcga  acggacaca  acagtggct  tggaggaga  tcggagaag  gcgacttgc  960
cagtgagca  ccgtgcttc  aaagtgacc  cggacgcag  ttcacgatg  gagaaagga  1020
cggcgcaat  aagcaagag  ccgaagaac  ccccacaaa  aagaaccgg  tgcagcttt  1080
ggatgatga  ggccatttc  ctagcagtg  cctgatcag  tccccgttc  tgggcccac  1140
cccacacca  cctcctttc  gcctgccct  ctacctgat  ccaccttca  cgactgcct  1200
cctgcccat  ctggagaag  gctggtatc  cacctcagt  ccagtgcta  acccaggcc  1260
caacgcctc  gccgcagcc  tctctagct  catgaaccc  gacaagatc  cggctccct  1320
gctcatgcc  cagagactc  cttctccct  gccagctca  ccgtccgtc  actcttctg  1380
cttgctcca  gctctgaag  caatccccc  tttaaactt  gaaaccaaa  actaaactc  1440
ctaggggat  ctgctgctt  gctttcctt  ctcgctact  cctaaaaag  aacaaaaaa  1500
tttttgtga  tgctgcaag  ttgttgcat  gtgtatact  agataatct  aggcatgga  1560
agcagattc  gggtgtgtg  gtgtgtgtg  gtgtgtgtg  gtatgtgcg  gtgcgtgca  1620
atgtgtgcc  gcgtgttgg  ataggactt  aaagctcct  ttggcatag  gaagtcacg  1680
aggattgct  gacatcagg  gacttgggg  ggattgtag  agacgtctg  gcttttccc  1740
acccagaga  tagccccct  cgatacaca  cagctggat  ttcaaaagc  tcaaagtct  1800
ggtctgtga  tcactcttc  gtttgggag  tgggtctgt  gctttgatc  gaaggtact  1860
tcaaaagag  gctttccag  gctcagctc  caaccagct  ttaggaccc  acccttttg  1920
ctttattgt  gacgtgact  accagacgt  ggggagaga  agcagtcag  ccgagcttt  1980
tgctaacat  gggaggtag  aggcactgg  atagcacgg  agtggtttg  ggaggtttc  2040
gcaggtctg  tccccaccc  tgcctcgga  gaataaaga  aatgtagtt  cctactcag  2100
ctttcgtag  gattagctt  ctaaggaac  gaaaatggg  cccttgtac  agctgagct  2160
ccccggagg  agggaggag  tccctgggc  tctggcacc  gtttctagg  ctaaccatt  2220
gtacttact  tgcagggaa  caaaccaag  tctgagaaa  gcggacacc  cgagcgagc  2280
ccccaaagt  cacaaagct  agtaaaaag  tgccccctt  aaacagaac  agactcagt  2340
ttcaattcc  tcctaaaac  ccttttaac  aagcttagc  tctcaaagg  ctaaccaag  2400
cttggcacc  ccagatcct  tctgtaggc  aattcctct  gcccaacgg  atatggagt  2460
tccttattg  taaaaagga  tccgtctcc  tcaaagaag  tttattttt  gtccagagt  2520
cttgttttc  cgatgtgtc  agccagctc  gcagcagct  ttcaagatg  actatgcct  2580
attgctgat  gtgttttaa  tttttcttt  cctgttttt  ttttggtat  aagtcgttg  2640
ctttatttg  aaagctgtt  taaatatat  ttatataaa  atattaaaa  ggaaaatgt  2700
tcagatgtt  atttgtata  ttacttgat  cacacagtg  gaaaaaatg  atgtattcc  2760
gtttttgaa  agaagaata  ttttttttt  tctagggag  ggtacagtg  ttatatttt  2820
gagccttcc  gaaggtgta  aattgtaaa  atttttatc  atgagtaaa  gttaagtag  2880
tgttttaaa  tacttaata  aataattct  ttcctgtgg  ag  2922



<210> 471
<211> 412
<212> PRT
<213> Homo sapiens
<308> O14503
<400> 471

Met Glu Arg Ile Pro Ser Ala Gln Pro Pro Pro Ala Cys Leu Pro Lys 
  1               5                  10                  15
Ala Pro Gly Leu Glu His Gly Asp Leu Pro Gly Met Tyr Pro Ala His 
             20                  25                  30
Met Tyr Gln Val Tyr Lys Ser Arg Arg Gly Ile Lys Arg Ser Glu Asp 
         35                  40                  45
Ser Lys Glu Thr Tyr Lys Leu Pro His Arg Leu Ile Glu Lys Lys Arg 
     50                  55                  60
Arg Asp Arg Ile Asn Glu Cys Ile Ala Gln Leu Lys Asp Leu Leu Pro 
 65                  70                  75                  80
Glu His Leu Lys Leu Thr Thr Leu Gly His Leu Glu Lys Ala Val Val 
                 85                  90                  95
Leu Glu Leu Thr Leu Lys His Val Lys Ala Leu Thr Asn Leu Ile Asp 
             100                105                110
Gln Gln Gln Gln Lys Ile Ile Ala Leu Gln Ser Gly Leu Gln Ala Gly 
         115                120                125
Glu Leu Ser Gly Arg Asn Val Glu Thr Gly Gln Glu Met Phe Cys Ser 
     130                135                140
Gly Phe Gln Thr Cys Ala Arg Glu Val Leu Gln Tyr Leu Ala Lys His 
 145                150                155                160
Glu Asn Thr Arg Asp Leu Lys Ser Ser Gln Leu Val Thr His Leu His 
                 165                170                175
Arg Val Val Ser Glu Leu Leu Gln Gly Gly Thr Ser Arg Lys Pro Ser 
             180                185                190
Asp Pro Ala Pro Lys Val Met Asp Phe Lys Glu Lys Pro Ser Ser Pro 
         195                200                205
Ala Lys Gly Ser Glu Gly Pro Gly Lys Asn Cys Val Pro Val Ile Gln 
     210                215                220
Arg Thr Phe Ala His Ser Ser Gly Glu Gln Ser Gly Ser Asp Thr Asp 
 225                230                235                240
Thr Asp Ser Gly Tyr Gly Gly Glu Ser Glu Lys Gly Asp Leu Arg Ser 
                 245                250                255
Glu Gln Pro Cys Phe Lys Ser Asp His Gly Arg Arg Phe Thr Met Gly 
             260                265                270
Glu Arg Ile Gly Ala Ile Lys Gln Glu Ser Glu Glu Pro Pro Thr Lys 
         275                280                285
Lys Asn Arg Met Gln Leu Ser Asp Asp Glu Gly His Phe Thr Ser Ser 
     290                295                300
Asp Leu Ile Ser Ser Pro Phe Leu Gly Pro His Pro His Gln Pro Pro 
 305                310                315                320
Phe Cys Leu Pro Phe Tyr Leu Ile Pro Pro Ser Ala Thr Ala Tyr Leu 
                 325                330                335
Pro Met Leu Glu Lys Cys Trp Tyr Pro Thr Ser Val Pro Val Leu Tyr 
             340                345                350
Pro Gly Leu Asn Ala Ser Ala Ala Ala Leu Ser Ser Phe Met Asn Pro 
         355                360                365
Asp Lys Ile Ser Ala Pro Leu Leu Met Pro Gln Arg Leu Pro Ser Pro 
     370                375                380
Leu Pro Ala His Pro Ser Val Asp Ser Ser Val Leu Leu Gln Ala Leu 
 385                390                395                400
Lys Pro Ile Pro Pro Leu Asn Leu Glu Thr Lys Asp 
                 405                410



<210> 472
<211> 1103
<212> DNA
<213> Rattus norvegicus
<308> AF009603
<400> 472

ggcgatgat  gcaactttg  tccggctct  ggtgaggta  gagaagcca  gagggagct  60
tcggaggtc  aggactctt  ggacatgga  gtgaagcag  acttcatcg  cccccttca  120
aatcttcat  acaaagatc  gagggagat  cagcatcac  tgaaaaagc  ggaaggccg  180
cgcttagac  ttgattata  gaagaagcg  caaggaaag  ttccagacg  agaactccg  240
caagctctg  agaaatttg  tgagtctaa  gaaatcgct  agtcgagca  gttcaacct  300
ttggagatg  atattgaac  ggtgagcca  ctctctgca  ttgttcagg  tcagctgga  360
taccacaaa  aggctgtgc  gatcctgca  caggtcact  tcaggctgg  agagagaat  420
agacaagct  catctcaac  aagaaggga  tatcagccc  aaccacgaa  gagcctaga  480
tttgccact  gagacggta  gcagcccaa  gggggtctc  cccacacag  cacacccaa  540
cctgcaggt  tccaaatgg  tcagccttg  tgccgagcc  tgtatgact  tgaacctga  600
aatgaaggg  agttgggtt  taaagaggg  gatatcatc  cgctcacta  tcagattga  660
gagaactgg  atgagggga  gcttcatgg  cagtccggc  ttttcccca  caactatgt  720
gaaattctg  ttgctctgc  ccattaggg  cctgtgctg  ctggctcac  tccttctga  780
ccaratagt  aagtttaac  actgctttg  taatgccgc  tccaataca  cacgaatgc  840
ggccgcagt  gatgattca  caagcccac  cgtgccctg  gttggcctg  gtgctccta  900
aggagacac  gtgatagat  gtatcttcc  aggccactg  gcctggcac  tgctttaaa  960
caccatctg  gactagccc  tggtcacag  aactggcta  gccgttctc  ggaggctgt  1020
gttcctgat  acccacacc  cagaaaacc  ctcctcact  aagatattg  ctctcaccc  1080
aagggccat  tcaagctcc  tgt  1103



<210> 473
<211> 248
<212> PRT
<213> Rattus norvegicus
<308> O35179
<400> 473

Gly Asp Asp Cys Asn Phe Gly Pro Ala Leu Gly Glu Val Gly Glu Ala 
  1               5                  10                  15
Met Arg Glu Leu Ser Glu Val Lys Asp Ser Leu Asp Met Glu Val Lys 
             20                  25                  30
Gln Asn Phe Ile Asp Pro Leu Gln Asn Leu His Asp Lys Asp Leu Arg 
         35                  40                  45
Glu Ile Gln His His Leu Lys Lys Leu Glu Gly Arg Arg Leu Asp Phe 
     50                  55                  60
Asp Tyr Lys Lys Lys Arg Gln Gly Lys Ile Pro Asp Glu Glu Leu Arg 
 65                  70                  75                  80
Gln Ala Leu Glu Lys Phe Asp Glu Ser Lys Glu Ile Ala Glu Ser Ser 
                 85                  90                  95
Met Phe Asn Leu Leu Glu Met Asp Ile Glu Gln Val Ser Gln Leu Ser 
             100                105                110
Ala Leu Val Gln Ala Gln Leu Glu Tyr His Lys Gln Ala Val Gln Ile 
         115                120                125
Leu Gln Gln Val Thr Val Arg Leu Glu Glu Arg Ile Arg Gln Ala Ser 
     130                135                140
Ser Gln Pro Arg Arg Glu Tyr Gln Pro Lys Pro Arg Met Ser Leu Glu 
 145                150                155                160
Phe Ala Thr Gly Asp Gly Thr Gln Pro Asn Gly Gly Leu Ser His Thr 
                 165                170                175
Gly Thr Pro Lys Pro Ala Gly Val Gln Met Asp Gln Pro Cys Cys Arg 
             180                185                190
Ala Leu Tyr Asp Phe Glu Pro Glu Asn Glu Gly Glu Leu Gly Phe Lys 
         195                200                205
Glu Gly Asp Ile Ile Thr Leu Thr Asn Gln Ile Asp Glu Asn Trp Tyr 
     210                215                220
Glu Gly Met Leu His Gly Gln Ser Gly Phe Phe Pro Ile Asn Tyr Val 
 225                230                235                240
Glu Ile Leu Val Ala Leu Pro His 
                 245



<210> 474
<211> 2540
<212> DNA
<213> Homo sapiens
<308> NM_003026
<400> 474

cgccgcctc  ctcccgcac  gcagccgcc  gcgcggcct  ctgcaccat  tcggtggcc  60
gcctcaaga  gcagttcca  aaagccact  agaaagtga  tgagaaggt  ggaggagct  120
aaggaacca  gctagatga  gacttcaaa  agatggaaa  gaaagtgga  gtcaccagc  180
gggctgtga  ggaaataat  actaaaaca  ttgaatacc  tcaacccaa  ccagcttcc  240
gagctaagc  cagcatgat  aacaccatg  caaaaatcc  tggccagga  aaggggcca  300
gctatcctc  ggcagaggc  ctgctggca  aggccatgc  caaatttgg  agagagctt  360
gagatgatt  caactttgg  ccagcactt  gtgaggtcg  ggaggccat  cgggaactg  420
cggaggtca  agactcttt  gacatagaa  tgaagcaga  cttcattga  cctcttcag  480
atcttcatg  caaagatct  agggaaatt  aacatcatc  aaagaagtt  gagggtcga  540
gcctggatt  tgattataa  aagaaacga  aaggcaaga  tccggatga  gagcttcgt  600
aagctctag  gaaatttga  gagtctaag  aaattgctg  gtcaagcat  ttcaatctc  660
tggagatgg  tattgaaca  gtgagccag  tctctgcac  tgtgcaagc  cagctggag  720
accacaagc  ggcagtcca  atcctgcag  aagtcacgg  cagactgga  gaaagaata  780
gacaggctt  atctcagcc  agaagggaa  atcaaccta  accacgaat  agcctggag  840
ttccaactg  agacagtac  cagcccaat  ggggtctct  ccacacagg  actcccaaa  900
cttcaggtg  ccaaatgga  cagccctgc  gccgagctc  gtacgactt  gaacctgaa  960
atgaagggg  gttgggatt  aaagagggc  atatcatca  actcactaa  caaattgat  1020
agaactggt  tgaggggat  ctgcatggc  attcaggct  cttccccat  aattatgtg  1080
aaattctgg  tgccctgcc  cattaggat  ttatgctgg  tggctcgcc  cctcttgac  1140
cagatagtt  cggttaacc  ctgctttgg  aatgctgct  ataacacat  ccaagtgca  1200
gccgcagtg  tccacgtca  ccagcccca  caagtgact  tggttgact  gtgggctcc  1260
acaggagtc  tggtgatgg  tgatatcct  ttagcctgg  gggcgtggc  tgtgctttt  1320
aaaacatca  ctgagacca  ccagtagtc  cagaactgc  gtttacaca  ttctcagga  1380
gctgtggtt  attagaata  gaccatgag  catttcaca  aaaaaccat  ccaccgaag  1440
tattgtcta  caccccagg  gccatctga  ggtctcttt  catttctcc  tgcaaagag  1500
agaaagctt  tgctttcac  ctgtccctt  ccaaatatg  gagtcatgg  attgtcaaa  1560
taagccttc  ctcaccagc  aattgtctc  tgatctgaa  gaatttgtc  cttaatgca  1620
ccatagaaa  gtgttaatt  tgggttcaa  gcattctct  caaataggc  tctcagctc  1680
tcacactta  ggctatttc  gacgtatag  cagttttct  ccctccttg  tattaaagc  1740
agagtcgta  ttccaaatt  tttttcagt  agacagtta  tcagcatta  tgtgagagg  1800
actgaaaag  aattctcca  tatgaggaa  tgggaagaa  tctggtatc  aagcttaaa  1860
ttcttgcta  acagaacta  gtatgtatt  aggctattc  gaagggcac  gggaagggg  1920
acaaatatc  tcacttcag  tttatttgt  aattacatg  ttcatgaat  catttggca  1980
agagacaca  ggaagaaaa  actagtaac  aactttcca  tagttcata  actgagaaa  2040
agtaaatac  tttcctttc  acttttacc  tgtgttctt  gaacatcat  tgtgcagat  2100
ctgccctca  tgaggacca  ataaagatg  tttttgtgc  tagcagttt  aggtatatg  2160
ctggcatat  caaaactct  tcccaattc  gtcgctact  ttacttctg  cctttctat  2220
catcgtctt  attttgtgt  tacagtgct  tgtgtaagc  tatcagtgt  tttttttat  2280
tgtatcagt  atgaaagtc  tgttaggta  ccagagttc  atttatcta  ctgtacaga  2340
tctttcaga  gtttaacgt  ctgcttccg  tgtgccacc  gcagtagtg  atcatgtgg  2400
gtgaaaggc  aatcttact  cttaatgta  aaactctca  cacaggaag  atcgctgtt  2460
ccaataaat  ttgctgaag  cagaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2520
aaaaaaaaa  aaaaaaaaaa  2540



<210> 475
<211> 352
<212> PRT
<213> Homo sapiens
<308> Q99962
<400> 475

Met Ser Val Ala Gly Leu Lys Lys Gln Phe His Lys Ala Thr Gln Lys 
  1               5                  10                  15
Val Ser Glu Lys Val Gly Gly Ala Glu Gly Thr Lys Leu Asp Asp Asp 
             20                  25                  30
Phe Lys Glu Met Glu Arg Lys Val Asp Val Thr Ser Arg Ala Val Met 
         35                  40                  45
Glu Ile Met Thr Lys Thr Ile Glu Tyr Leu Gln Pro Asn Pro Ala Ser 
     50                  55                  60
Arg Ala Lys Leu Ser Met Ile Asn Thr Met Ser Lys Ile Arg Gly Gln 
 65                  70                  75                  80
Glu Lys Gly Pro Gly Tyr Pro Gln Ala Glu Ala Leu Leu Ala Glu Ala 
                 85                  90                  95
Met Leu Lys Phe Gly Arg Glu Leu Gly Asp Asp Cys Asn Phe Gly Pro 
             100                105                110
Ala Leu Gly Glu Val Gly Glu Ala Met Arg Glu Leu Ser Glu Val Lys 
         115                120                125
Asp Ser Leu Asp Ile Glu Val Lys Gln Asn Phe Ile Asp Pro Leu Gln 
     130                135                140
Asn Leu His Asp Lys Asp Leu Arg Glu Ile Gln His His Leu Lys Lys 
 145                150                155                160
Leu Glu Gly Arg Arg Leu Asp Phe Asp Tyr Lys Lys Lys Arg Gln Gly 
                 165                170                175
Lys Ile Pro Asp Glu Glu Leu Arg Gln Ala Leu Glu Lys Phe Asp Glu 
             180                185                190
Ser Lys Glu Ile Ala Glu Ser Ser Met Phe Asn Leu Leu Glu Met Asp 
         195                200                205
Ile Glu Gln Val Ser Gln Leu Ser Ala Leu Val Gln Ala Gln Leu Glu 
     210                215                220
Tyr His Lys Gln Ala Val Gln Ile Leu Gln Gln Val Thr Val Arg Leu 
 225                230                235                240
Glu Glu Arg Ile Arg Gln Ala Ser Ser Gln Pro Arg Arg Glu Tyr Gln 
                 245                250                255
Pro Lys Pro Arg Met Ser Leu Glu Phe Pro Thr Gly Asp Ser Thr Gln 
             260                265                270
Pro Asn Gly Gly Leu Ser His Thr Gly Thr Pro Lys Pro Ser Gly Val 
         275                280                285
Gln Met Asp Gln Pro Cys Cys Arg Ala Leu Tyr Asp Phe Glu Pro Glu 
     290                295                300
Asn Glu Gly Glu Leu Gly Phe Lys Glu Gly Asp Ile Ile Thr Leu Thr 
 305                310                315                320
Asn Gln Ile Asp Glu Asn Trp Tyr Glu Gly Met Leu His Gly His Ser 
                 325                330                335
Gly Phe Phe Pro Ile Asn Tyr Val Glu Ile Leu Val Ala Leu Pro His 
             340                345                350



<210> 476
<211> 2436
<212> DNA
<213> Rattus norvegicus
<308> AF013144
<400> 476

agctttccg  ggcagcgag  ggcggggcc  ggtgctgag  gagcggggc  tggagagcg  60
cgcgcggcc  ctcgcgccg  gctccgttt  caggccaca  cccccgcga  gtggcccgc  120
ggccctggg  cgcccgtcc  ctggcagct  tggtgagcg  agcgtcggg  cggcatgaa  180
gtcacgtcg  tcgacgggc  ccggctgcg  aagatgctc  gcaaggagg  ggaggcgcg  240
tgcgtggtg  tcgattgcc  gccctacct  gccttcgcc  cgtcgagcg  gcgcggctc  300
ctcaacgtc  acctcaact  cgtggtgct  cggcgggcc  ggggcggcg  ggtgtctgc  360
cgctacgtg  tggccgacg  ggcagcccg  gctcggctg  tgcaggagg  cggcggcgg  420
gtggcggcg  tggtcgtgc  ggaccaggg  agccgccac  ggcagaagc  gcgggagga  480
agtgccgcg  gcgtcgtcc  cacctcgct  ctggcctgt  tgtccgccg  accgcgggt  540
tacttcctt  aaggtgggt  cgagacctt  tactcacag  atcctgagt  ctgtgtgga  600
gcgaagccc  tttcacaag  gaagctcga  ggtgaaaga  gcctcctca  ccagtgcgg  660
aagcccatt  tcagcgtcg  ctacagacc  gcttatgac  agggtggcc  agttgaaat  720
cttcccttc  tctaccttg  aagtgccta  catgcatcc  agtgcgagt  cctcgccaa  780
ctgcacatc  cagccctgc  gaatgtttc  cgccggacc  ctgaggcct  cacaaccca  840
ctacactac  agtggatcc  tgtggagga  agccacacc  ccgacatta  ctcccactt  900
caagaagca  tagatttta  tgactgtgt  agggaagag  gaggcaagg  cctggttca  960
tgtgaagcc  gggtctccc  gtcgcccac  atctgcatg  cttacctca  gaagaccaa  1020
cagttccgc  tgaaggagg  cttcgagta  atcaagcag  ggaggagcg  ggtctctcc  1080
aactttggc  tcatgggac  gctcctgca  tatgagtct  agatcctgc  ctccacacc  1140
accccccaa  ctccctcct  ccaagggga  gcagccagc  ccaccttta  aggccactt  1200
cagacactg  gccctgata  gcagggtgc  tactgcaca  tccctacct  agtgctggc  1260
ccggtgccc  cccacgcca  cgtcgcaga  ctccacagg  gccccgtgg  cacagccac  1320
tcctgctga  accggtcgg  taccagcgc  tccccaaga  caactgtga  ctttggatt  1380
tttaaactt  tggacattt  atacccgtg  aatactgaa  acctctctc  gtcccgctg  1440
cccggtgag  tggtgaggg  tcagcaggc  tgcagatgc  cttcaggct  acccggagg  1500
tggtttctc  cgattgtag  aaggccaag  catgccccc  tagcacagc  gcgtgctaa  1560
tactgtact  ccagaagcc  cgcccactc  ggaccgcct  atccttgca  ctcagaagt  1620
ccggcttct  atttcaagt  taaggcaat  cacagtcgc  gcaaagtag  agcaagctg  1680
gctggacca  gaggggagg  gtccgcccg  ctgggagga  gcacaagtt  cactgttaa  1740
ttgaatttc  gccaacttt  tctgtctct  tcctctgtc  cttcaggga  gagagctgg  1800
caccgctca  tcagaaaag  taaccccgc  ggatttgtc  agacaaaag  acctgcccg  1860
ctgaaccca  tgtttctga  gttctgtct  ggatcccat  gaagctgtt  gtgtaagga  1920
aagctcctg  ctcattgga  tttcttgct  accgagggc  ccttggtga  cttggactt  1980
ggcatggtt  ttacaaata  ttgaacctg  cccattgta  ctctcccta  agcacctct  2040
gtgtcattc  gaaagttgt  agaccctag  ccaaaaacc  cccctttga  ggggtagca  2100
gaactgcct  cgttctggg  cagtggtgg  gactgacat  ctttttcag  ttagtgtcc  2160
gtgtgcttt  tttgtcatc  attgtgaca  tgtttccct  cctaccctg  ggagtcgtt  2220
tcaaactac  gattctggg  tctgcatcg  ttgcaatgt  gtactacta  gtccttcgt  2280
gattgtttt  ccaaggggg  aaaggcaat  agtcacccc  aaacccatg  gaatgtgaa  2340
aaaagcagt  ttgatgttt  ttttatata  atatatata  atgtagtac  aaattaaaa  2400
aatgtcaaa  aataaaaat  aaaagtgct  agtgaa  2436



<210> 477
<211> 384
<212> PRT
<213> Rattus norvegicus
<308> O54838
<400> 477

Met Lys Val Thr Ser Leu Asp Gly Arg Arg Leu Arg Lys Met Leu Arg 
  1               5                  10                  15
Lys Glu Ala Glu Ala Arg Cys Val Val Leu Asp Cys Arg Pro Tyr Leu 
             20                  25                  30
Ala Phe Ala Ala Ser Ser Val Arg Gly Ser Leu Asn Val Asn Leu Asn 
         35                  40                  45
Ser Val Val Leu Arg Arg Ala Arg Gly Gly Ala Val Ser Ala Arg Tyr 
     50                  55                  60
Val Leu Ala Asp Glu Ala Ala Arg Ala Arg Leu Leu Gln Glu Gly Gly 
 65                  70                  75                  80
Gly Gly Val Ala Ala Val Val Val Leu Asp Gln Gly Ser Arg His Trp 
                 85                  90                  95
Gln Lys Leu Arg Glu Glu Ser Ala Ala Arg Val Val Leu Thr Ser Leu 
             100                105                110
Leu Ala Cys Leu Ser Ala Gly Pro Arg Val Tyr Phe Leu Lys Gly Gly 
         115                120                125
Tyr Glu Thr Phe Tyr Ser Gln Tyr Pro Glu Cys Cys Val Asp Ala Lys 
     130                135                140
Pro Ile Ser Gln Glu Lys Leu Glu Gly Glu Arg Gly Leu Leu Ser Gln 
 145                150                155                160
Cys Gly Lys Pro Ile Leu Ser Val Ala Tyr Arg Pro Ala Tyr Asp Gln 
                 165                170                175
Gly Gly Pro Val Glu Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala Tyr 
             180                185                190
His Ala Ser Lys Cys Glu Phe Leu Ala Asn Leu His Ile Thr Ala Leu 
         195                200                205
Leu Asn Val Ser Arg Arg Thr Ser Glu Ala Cys Thr Thr His Leu His 
     210                215                220
Tyr Lys Trp Ile Pro Val Glu Asp Ser His Thr Ala Asp Ile Ser Ser 
 225                230                235                240
His Phe Gln Glu Ala Ile Asp Phe Ile Asp Cys Val Arg Glu Glu Gly 
                 245                250                255
Gly Lys Val Leu Val His Cys Glu Ala Gly Val Ser Arg Ser Pro Thr 
             260                265                270
Ile Cys Met Ala Tyr Leu Met Lys Thr Lys Gln Phe Arg Leu Lys Glu 
         275                280                285
Ala Phe Glu Tyr Ile Lys Gln Arg Arg Ser Val Val Ser Pro Asn Phe 
     290                295                300
Gly Phe Met Gly Gln Leu Leu Gln Tyr Glu Ser Glu Ile Leu Pro Ser 
 305                310                315                320
Thr Pro Thr Pro Gln Pro Pro Ser Cys Gln Gly Glu Ala Ala Ser Ser 
                 325                330                335
Thr Phe Ile Gly His Leu Gln Thr Leu Ser Pro Asp Met Gln Gly Ala 
             340                345                350
Tyr Cys Thr Phe Pro Thr Ser Val Leu Ala Pro Val Pro Thr His Ala 
         355                360                365
Thr Val Ala Glu Leu His Arg Ser Pro Val Ala Thr Ala Thr Ser Cys 
     370                375                380



<210> 478
<211> 2473
<212> DNA
<213> Homo sapiens
<308> NM_004419
<400> 478

aatcgcgaa  cccggcgag  ggcgcgctg  ctatcgagc  agcggggcg  aaccgggag  60
tgcgccgcc  ctcgggcgc  gggctccgt  gcggccgca  ccccgcggg  cgccctccc  120
tgcctcgcc  gcggacacc  tggccgtgg  caccctggc  gtgggcacc  gcggggcgc  180
gcgcgggcg  tgcgcggcg  cggcggcgg  atgaaggtc  cgtcgctcg  cgggcgcca  240
ctgcgcaag  tgctccgca  ggaggcggc  gcgcgctgc  tggtgctcg  ctgccggcc  300
tatctggcc  tcgctgcct  gaacgtgcg  ggctcgctc  acgtcaacc  caactcggt  360
gtgctgcgg  gggcccggg  cggcgcggt  tcggcgcgc  acgtgctgc  cgacgaggc  420
gcgcgcgcg  ggctcctgc  ggagggcgg  ggcggcgtc  cggccgtgg  ggtgctgga  480
cagggcagc  gccactggc  gaagctgcg  gaggagagc  ccgcgcgtg  cgtcctcac  540
tcgctactc  cttgcctac  cgccggccc  cgggtctac  tcctcaaag  gggatatga  600
actttctac  cggaatatc  tgagtgttg  gtggatgta  aacccattt  acaagagaa  660
attgagagt  agagagccc  catcagcca  tgtggaaaa  cagtggtaa  tgtcagcta  720
aggccagct  atgaccagg  tggcccagt  gaaatcctt  ccttcctct  ccttggaag  780
gcctaccat  catccaagt  cgagttcct  gccaacttg  acatcacag  cctgctgaa  840
gtctcccga  ggacctccg  ggcctgcat  acccaccta  actacaaat  gatccctgt  900
gaagacagc  acacggctg  cattagctc  cactttcaa  aagcaatag  cttcattga  960
tgtgtcagg  aaaagggag  caaggtcct  gtccactgt  aggctggga  ctcccgttc  1020
cccaccatc  gcatggctt  ccttatgaa  accaagcag  tccgcctga  ggaggcctt  1080
gattacatc  agcagagga  gagcatggt  tcgcccaac  ttggcttca  gggccagct  1140
ctgcagtac  aatctgaga  cctgccctc  acgcccaac  cccagcctc  ctcctgcca  1200
ggggaggca  caggctctt  actgatagg  catttgcag  cactgagcc  tgacatgca  1260
ggtgcctac  gcacattcc  tgcctcggt  ctggcaccg  tgcctaccc  ctcaacagt  1320
tcagagctc  gcagaagcc  tgtggcaac  gccacatcc  gctaaaact  ggatggagg  1380
atcggccca  ccccaagag  aactgtgat  tttgttttt  agactcatg  acatttcat  1440
cctgtgcaa  actgaagac  tcattctgt  atgctgccc  agtgagata  tgagtggtc  1500
ccaggcttg  aaatgaact  cagacggac  tcagggtag  ttctcggga  tgaaggaag  1560
ccaagccat  acgggagca  agcatgtgc  gactactgt  cttccagac  cctgccctc  1620
tgggactgc  cagtccttg  acctcagag  tcgcctttt  atttcaagc  taagccaat  1680
aatacctgc  gcaacgtgg  agaaagaag  tgctggacc  ggagaaaag  cagttatga  1740
gccaattca  tttgaagga  gcacaattt  caccttatt  tttgaactt  ggcagtttc  1800
atgtctgtc  ctgttgctt  ggggcataa  ctgatcacc  tctagttgg  aaagtcacc  1860
tacagggtt  gtagggaca  gatcagcat  ctgatttga  ccctgaaat  ttgtgtaga  1920
accctcttg  gtccaatga  gtagttggt  gaagtagca  gatgttggc  tttctggat  1980
ttttttgcc  tgggttctt  actgacctt  gactttggc  tgattctta  tcatacttg  2040
acttgtctc  ttccacctc  tctcagagc  actcttcct  tgggaaaag  gttcttcag  2100
tcatagacc  aaaaagtca  accttcgag  tggtagcag  agattccag  aggagaagg  2160
tacttgcta  gtatcctgg  tcagtggcg  tgcaaactg  tttcctcag  tgcctgtcc  2220
tctgtgtgc  tatgtctct  gtgacaatt  ttttcctcc  tgcccctgg  ggttgtctt  2280
aactgtgga  ttctgggat  tgcagattt  gcaacgtgg  actactttt  tttcttttt  2340
tctgttagt  atttctcca  gggaaaagg  aataatttt  taagacccg  gtgaatgtg  2400
agaaaagca  tatgttact  gttgttgtt  ttgttcttg  tttttatat  taaaataaa  2460
atagtgaaa  gag  2473



<210> 479
<211> 384
<212> PRT
<213> Homo sapiens
<308> Q16690
<400> 479

Met Lys Val Thr Ser Leu Asp Gly Arg Gln Leu Arg Lys Met Leu Arg 
  1               5                  10                  15
Lys Glu Ala Ala Ala Arg Cys Val Val Leu Asp Cys Arg Pro Tyr Leu 
             20                  25                  30
Ala Phe Ala Ala Ser Asn Val Arg Gly Ser Leu Asn Val Asn Leu Asn 
         35                  40                  45
Ser Val Val Leu Arg Arg Ala Arg Gly Gly Ala Val Ser Ala Arg Tyr 
     50                  55                  60
Val Leu Pro Asp Glu Ala Ala Arg Ala Arg Leu Leu Gln Glu Gly Gly 
 65                  70                  75                  80
Gly Gly Val Ala Ala Val Val Val Leu Asp Gln Gly Ser Arg His Trp 
                 85                  90                  95
Gln Lys Leu Arg Glu Glu Ser Ala Ala Arg Val Val Leu Thr Ser Leu 
             100                105                110
Leu Ala Cys Leu Pro Ala Gly Pro Arg Val Tyr Phe Leu Lys Gly Gly 
         115                120                125
Tyr Glu Thr Phe Tyr Ser Glu Tyr Pro Glu Cys Cys Val Asp Val Lys 
     130                135                140
Pro Ile Ser Gln Glu Lys Ile Glu Ser Glu Arg Ala Leu Ile Ser Gln 
 145                150                155                160
Cys Gly Lys Pro Val Val Asn Val Ser Tyr Arg Pro Ala Tyr Asp Gln 
                 165                170                175
Gly Gly Pro Val Glu Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala Tyr 
             180                185                190
His Ala Ser Lys Cys Glu Phe Leu Ala Asn Leu His Ile Thr Ala Leu 
         195                200                205
Leu Asn Val Ser Arg Arg Thr Ser Glu Ala Cys Met Thr His Leu His 
     210                215                220
Tyr Lys Trp Ile Pro Val Glu Asp Ser His Thr Ala Asp Ile Ser Ser 
 225                230                235                240
His Phe Gln Glu Ala Ile Asp Phe Ile Asp Cys Val Arg Glu Lys Gly 
                 245                250                255
Gly Lys Val Leu Val His Cys Glu Ala Gly Ile Ser Arg Ser Pro Thr 
             260                265                270
Ile Cys Met Ala Tyr Leu Met Lys Thr Lys Gln Phe Arg Leu Lys Glu 
         275                280                285
Ala Phe Asp Tyr Ile Lys Gln Arg Arg Ser Met Val Ser Pro Asn Phe 
     290                295                300
Gly Phe Met Gly Gln Leu Leu Gln Tyr Glu Ser Glu Ile Leu Pro Ser 
 305                310                315                320
Thr Pro Asn Pro Gln Pro Pro Ser Cys Gln Gly Glu Ala Ala Gly Ser 
                 325                330                335
Ser Leu Ile Gly His Leu Gln Thr Leu Ser Pro Asp Met Gln Gly Ala 
             340                345                350
Tyr Cys Thr Phe Pro Ala Ser Val Leu Ala Pro Val Pro Thr His Ser 
         355                360                365
Thr Val Ser Glu Leu Ser Arg Ser Pro Val Ala Thr Ala Thr Ser Cys 
     370                375                380



<210> 480
<211> 2436
<212> DNA
<213> Rattus norvegicus
<308> AF013144
<400> 480

agctttccg  ggcagcgag  ggcggggcc  ggtgctgag  gagcggggc  tggagagcg  60
cgcgcggcc  ctcgcgccg  gctccgttt  caggccaca  cccccgcga  gtggcccgc  120
ggccctggg  cgcccgtcc  ctggcagct  tggtgagcg  agcgtcggg  cggcatgaa  180
gtcacgtcg  tcgacgggc  ccggctgcg  aagatgctc  gcaaggagg  ggaggcgcg  240
tgcgtggtg  tcgattgcc  gccctacct  gccttcgcc  cgtcgagcg  gcgcggctc  300
ctcaacgtc  acctcaact  cgtggtgct  cggcgggcc  ggggcggcg  ggtgtctgc  360
cgctacgtg  tggccgacg  ggcagcccg  gctcggctg  tgcaggagg  cggcggcgg  420
gtggcggcg  tggtcgtgc  ggaccaggg  agccgccac  ggcagaagc  gcgggagga  480
agtgccgcg  gcgtcgtcc  cacctcgct  ctggcctgt  tgtccgccg  accgcgggt  540
tacttcctt  aaggtgggt  cgagacctt  tactcacag  atcctgagt  ctgtgtgga  600
gcgaagccc  tttcacaag  gaagctcga  ggtgaaaga  gcctcctca  ccagtgcgg  660
aagcccatt  tcagcgtcg  ctacagacc  gcttatgac  agggtggcc  agttgaaat  720
cttcccttc  tctaccttg  aagtgccta  catgcatcc  agtgcgagt  cctcgccaa  780
ctgcacatc  cagccctgc  gaatgtttc  cgccggacc  ctgaggcct  cacaaccca  840
ctacactac  agtggatcc  tgtggagga  agccacacc  ccgacatta  ctcccactt  900
caagaagca  tagatttta  tgactgtgt  agggaagag  gaggcaagg  cctggttca  960
tgtgaagcc  gggtctccc  gtcgcccac  atctgcatg  cttacctca  gaagaccaa  1020
cagttccgc  tgaaggagg  cttcgagta  atcaagcag  ggaggagcg  ggtctctcc  1080
aactttggc  tcatgggac  gctcctgca  tatgagtct  agatcctgc  ctccacacc  1140
accccccaa  ctccctcct  ccaagggga  gcagccagc  ccaccttta  aggccactt  1200
cagacactg  gccctgata  gcagggtgc  tactgcaca  tccctacct  agtgctggc  1260
ccggtgccc  cccacgcca  cgtcgcaga  ctccacagg  gccccgtgg  cacagccac  1320
tcctgctga  accggtcgg  taccagcgc  tccccaaga  caactgtga  ctttggatt  1380
tttaaactt  tggacattt  atacccgtg  aatactgaa  acctctctc  gtcccgctg  1440
cccggtgag  tggtgaggg  tcagcaggc  tgcagatgc  cttcaggct  acccggagg  1500
tggtttctc  cgattgtag  aaggccaag  catgccccc  tagcacagc  gcgtgctaa  1560
tactgtact  ccagaagcc  cgcccactc  ggaccgcct  atccttgca  ctcagaagt  1620
ccggcttct  atttcaagt  taaggcaat  cacagtcgc  gcaaagtag  agcaagctg  1680
gctggacca  gaggggagg  gtccgcccg  ctgggagga  gcacaagtt  cactgttaa  1740
ttgaatttc  gccaacttt  tctgtctct  tcctctgtc  cttcaggga  gagagctgg  1800
caccgctca  tcagaaaag  taaccccgc  ggatttgtc  agacaaaag  acctgcccg  1860
ctgaaccca  tgtttctga  gttctgtct  ggatcccat  gaagctgtt  gtgtaagga  1920
aagctcctg  ctcattgga  tttcttgct  accgagggc  ccttggtga  cttggactt  1980
ggcatggtt  ttacaaata  ttgaacctg  cccattgta  ctctcccta  agcacctct  2040
gtgtcattc  gaaagttgt  agaccctag  ccaaaaacc  cccctttga  ggggtagca  2100
gaactgcct  cgttctggg  cagtggtgg  gactgacat  ctttttcag  ttagtgtcc  2160
gtgtgcttt  tttgtcatc  attgtgaca  tgtttccct  cctaccctg  ggagtcgtt  2220
tcaaactac  gattctggg  tctgcatcg  ttgcaatgt  gtactacta  gtccttcgt  2280
gattgtttt  ccaaggggg  aaaggcaat  agtcacccc  aaacccatg  gaatgtgaa  2340
aaaagcagt  ttgatgttt  ttttatata  atatatata  atgtagtac  aaattaaaa  2400
aatgtcaaa  aataaaaat  aaaagtgct  agtgaa  2436



<210> 481
<211> 384
<212> PRT
<213> Rattus norvegicus
<308> O54838
<400> 481

Met Lys Val Thr Ser Leu Asp Gly Arg Arg Leu Arg Lys Met Leu Arg 
  1               5                  10                  15
Lys Glu Ala Glu Ala Arg Cys Val Val Leu Asp Cys Arg Pro Tyr Leu 
             20                  25                  30
Ala Phe Ala Ala Ser Ser Val Arg Gly Ser Leu Asn Val Asn Leu Asn 
         35                  40                  45
Ser Val Val Leu Arg Arg Ala Arg Gly Gly Ala Val Ser Ala Arg Tyr 
     50                  55                  60
Val Leu Ala Asp Glu Ala Ala Arg Ala Arg Leu Leu Gln Glu Gly Gly 
 65                  70                  75                  80
Gly Gly Val Ala Ala Val Val Val Leu Asp Gln Gly Ser Arg His Trp 
                 85                  90                  95
Gln Lys Leu Arg Glu Glu Ser Ala Ala Arg Val Val Leu Thr Ser Leu 
             100                105                110
Leu Ala Cys Leu Ser Ala Gly Pro Arg Val Tyr Phe Leu Lys Gly Gly 
         115                120                125
Tyr Glu Thr Phe Tyr Ser Gln Tyr Pro Glu Cys Cys Val Asp Ala Lys 
     130                135                140
Pro Ile Ser Gln Glu Lys Leu Glu Gly Glu Arg Gly Leu Leu Ser Gln 
 145                150                155                160
Cys Gly Lys Pro Ile Leu Ser Val Ala Tyr Arg Pro Ala Tyr Asp Gln 
                 165                170                175
Gly Gly Pro Val Glu Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala Tyr 
             180                185                190
His Ala Ser Lys Cys Glu Phe Leu Ala Asn Leu His Ile Thr Ala Leu 
         195                200                205
Leu Asn Val Ser Arg Arg Thr Ser Glu Ala Cys Thr Thr His Leu His 
     210                215                220
Tyr Lys Trp Ile Pro Val Glu Asp Ser His Thr Ala Asp Ile Ser Ser 
 225                230                235                240
His Phe Gln Glu Ala Ile Asp Phe Ile Asp Cys Val Arg Glu Glu Gly 
                 245                250                255
Gly Lys Val Leu Val His Cys Glu Ala Gly Val Ser Arg Ser Pro Thr 
             260                265                270
Ile Cys Met Ala Tyr Leu Met Lys Thr Lys Gln Phe Arg Leu Lys Glu 
         275                280                285
Ala Phe Glu Tyr Ile Lys Gln Arg Arg Ser Val Val Ser Pro Asn Phe 
     290                295                300
Gly Phe Met Gly Gln Leu Leu Gln Tyr Glu Ser Glu Ile Leu Pro Ser 
 305                310                315                320
Thr Pro Thr Pro Gln Pro Pro Ser Cys Gln Gly Glu Ala Ala Ser Ser 
                 325                330                335
Thr Phe Ile Gly His Leu Gln Thr Leu Ser Pro Asp Met Gln Gly Ala 
             340                345                350
Tyr Cys Thr Phe Pro Thr Ser Val Leu Ala Pro Val Pro Thr His Ala 
         355                360                365
Thr Val Ala Glu Leu His Arg Ser Pro Val Ala Thr Ala Thr Ser Cys 
     370                375                380



<210> 482
<211> 2473
<212> DNA
<213> Homo sapiens
<308> NM_004419
<400> 482

aatcgcgaa  cccggcgag  ggcgcgctg  ctatcgagc  agcggggcg  aaccgggag  60
tgcgccgcc  ctcgggcgc  gggctccgt  gcggccgca  ccccgcggg  cgccctccc  120
tgcctcgcc  gcggacacc  tggccgtgg  caccctggc  gtgggcacc  gcggggcgc  180
gcgcgggcg  tgcgcggcg  cggcggcgg  atgaaggtc  cgtcgctcg  cgggcgcca  240
ctgcgcaag  tgctccgca  ggaggcggc  gcgcgctgc  tggtgctcg  ctgccggcc  300
tatctggcc  tcgctgcct  gaacgtgcg  ggctcgctc  acgtcaacc  caactcggt  360
gtgctgcgg  gggcccggg  cggcgcggt  tcggcgcgc  acgtgctgc  cgacgaggc  420
gcgcgcgcg  ggctcctgc  ggagggcgg  ggcggcgtc  cggccgtgg  ggtgctgga  480
cagggcagc  gccactggc  gaagctgcg  gaggagagc  ccgcgcgtg  cgtcctcac  540
tcgctactc  cttgcctac  cgccggccc  cgggtctac  tcctcaaag  gggatatga  600
actttctac  cggaatatc  tgagtgttg  gtggatgta  aacccattt  acaagagaa  660
attgagagt  agagagccc  catcagcca  tgtggaaaa  cagtggtaa  tgtcagcta  720
aggccagct  atgaccagg  tggcccagt  gaaatcctt  ccttcctct  ccttggaag  780
gcctaccat  catccaagt  cgagttcct  gccaacttg  acatcacag  cctgctgaa  840
gtctcccga  ggacctccg  ggcctgcat  acccaccta  actacaaat  gatccctgt  900
gaagacagc  acacggctg  cattagctc  cactttcaa  aagcaatag  cttcattga  960
tgtgtcagg  aaaagggag  caaggtcct  gtccactgt  aggctggga  ctcccgttc  1020
cccaccatc  gcatggctt  ccttatgaa  accaagcag  tccgcctga  ggaggcctt  1080
gattacatc  agcagagga  gagcatggt  tcgcccaac  ttggcttca  gggccagct  1140
ctgcagtac  aatctgaga  cctgccctc  acgcccaac  cccagcctc  ctcctgcca  1200
ggggaggca  caggctctt  actgatagg  catttgcag  cactgagcc  tgacatgca  1260
ggtgcctac  gcacattcc  tgcctcggt  ctggcaccg  tgcctaccc  ctcaacagt  1320
tcagagctc  gcagaagcc  tgtggcaac  gccacatcc  gctaaaact  ggatggagg  1380
atcggccca  ccccaagag  aactgtgat  tttgttttt  agactcatg  acatttcat  1440
cctgtgcaa  actgaagac  tcattctgt  atgctgccc  agtgagata  tgagtggtc  1500
ccaggcttg  aaatgaact  cagacggac  tcagggtag  ttctcggga  tgaaggaag  1560
ccaagccat  acgggagca  agcatgtgc  gactactgt  cttccagac  cctgccctc  1620
tgggactgc  cagtccttg  acctcagag  tcgcctttt  atttcaagc  taagccaat  1680
aatacctgc  gcaacgtgg  agaaagaag  tgctggacc  ggagaaaag  cagttatga  1740
gccaattca  tttgaagga  gcacaattt  caccttatt  tttgaactt  ggcagtttc  1800
atgtctgtc  ctgttgctt  ggggcataa  ctgatcacc  tctagttgg  aaagtcacc  1860
tacagggtt  gtagggaca  gatcagcat  ctgatttga  ccctgaaat  ttgtgtaga  1920
accctcttg  gtccaatga  gtagttggt  gaagtagca  gatgttggc  tttctggat  1980
ttttttgcc  tgggttctt  actgacctt  gactttggc  tgattctta  tcatacttg  2040
acttgtctc  ttccacctc  tctcagagc  actcttcct  tgggaaaag  gttcttcag  2100
tcatagacc  aaaaagtca  accttcgag  tggtagcag  agattccag  aggagaagg  2160
tacttgcta  gtatcctgg  tcagtggcg  tgcaaactg  tttcctcag  tgcctgtcc  2220
tctgtgtgc  tatgtctct  gtgacaatt  ttttcctcc  tgcccctgg  ggttgtctt  2280
aactgtgga  ttctgggat  tgcagattt  gcaacgtgg  actactttt  tttcttttt  2340
tctgttagt  atttctcca  gggaaaagg  aataatttt  taagacccg  gtgaatgtg  2400
agaaaagca  tatgttact  gttgttgtt  ttgttcttg  tttttatat  taaaataaa  2460
atagtgaaa  gag  2473



<210> 483
<211> 384
<212> PRT
<213> Homo sapiens
<308> Q16690
<400> 483

Met Lys Val Thr Ser Leu Asp Gly Arg Gln Leu Arg Lys Met Leu Arg 
  1               5                  10                  15
Lys Glu Ala Ala Ala Arg Cys Val Val Leu Asp Cys Arg Pro Tyr Leu 
             20                  25                  30
Ala Phe Ala Ala Ser Asn Val Arg Gly Ser Leu Asn Val Asn Leu Asn 
         35                  40                  45
Ser Val Val Leu Arg Arg Ala Arg Gly Gly Ala Val Ser Ala Arg Tyr 
     50                  55                  60
Val Leu Pro Asp Glu Ala Ala Arg Ala Arg Leu Leu Gln Glu Gly Gly 
 65                  70                  75                  80
Gly Gly Val Ala Ala Val Val Val Leu Asp Gln Gly Ser Arg His Trp 
                 85                  90                  95
Gln Lys Leu Arg Glu Glu Ser Ala Ala Arg Val Val Leu Thr Ser Leu 
             100                105                110
Leu Ala Cys Leu Pro Ala Gly Pro Arg Val Tyr Phe Leu Lys Gly Gly 
         115                120                125
Tyr Glu Thr Phe Tyr Ser Glu Tyr Pro Glu Cys Cys Val Asp Val Lys 
     130                135                140
Pro Ile Ser Gln Glu Lys Ile Glu Ser Glu Arg Ala Leu Ile Ser Gln 
 145                150                155                160
Cys Gly Lys Pro Val Val Asn Val Ser Tyr Arg Pro Ala Tyr Asp Gln 
                 165                170                175
Gly Gly Pro Val Glu Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala Tyr 
             180                185                190
His Ala Ser Lys Cys Glu Phe Leu Ala Asn Leu His Ile Thr Ala Leu 
         195                200                205
Leu Asn Val Ser Arg Arg Thr Ser Glu Ala Cys Met Thr His Leu His 
     210                215                220
Tyr Lys Trp Ile Pro Val Glu Asp Ser His Thr Ala Asp Ile Ser Ser 
 225                230                235                240
His Phe Gln Glu Ala Ile Asp Phe Ile Asp Cys Val Arg Glu Lys Gly 
                 245                250                255
Gly Lys Val Leu Val His Cys Glu Ala Gly Ile Ser Arg Ser Pro Thr 
             260                265                270
Ile Cys Met Ala Tyr Leu Met Lys Thr Lys Gln Phe Arg Leu Lys Glu 
         275                280                285
Ala Phe Asp Tyr Ile Lys Gln Arg Arg Ser Met Val Ser Pro Asn Phe 
     290                295                300
Gly Phe Met Gly Gln Leu Leu Gln Tyr Glu Ser Glu Ile Leu Pro Ser 
 305                310                315                320
Thr Pro Asn Pro Gln Pro Pro Ser Cys Gln Gly Glu Ala Ala Gly Ser 
                 325                330                335
Ser Leu Ile Gly His Leu Gln Thr Leu Ser Pro Asp Met Gln Gly Ala 
             340                345                350
Tyr Cys Thr Phe Pro Ala Ser Val Leu Ala Pro Val Pro Thr His Ser 
         355                360                365
Thr Val Ser Glu Leu Ser Arg Ser Pro Val Ala Thr Ala Thr Ser Cys 
     370                375                380



<210> 484
<211> 856
<212> DNA
<213> Rattus norvegicus
<308> AF014009
<400> 484

ccagcgtca  cactgccgc  atgcccgga  ggctgcttc  cggggacga  gcccccaac  60
ttgaggcca  taccaccat  ggccacatc  gcttccacg  tttcctagg  gattcatgg  120
gcattctct  ttcccaccc  cgggacttt  ccccagtgt  caccacaga  cttggcaga  180
ctgcaaagc  ggcgccaga  tttgccaag  ggaatgtta  gttgattgc  ctttcaata  240
actctgttg  ggaccattt  gcctggagc  aggacatca  tgcttacaa  ggtgcagca  300
ccacagaaa  gctaccatt  cccatcatc  acgataagg  cagggacct  gccatcctg  360
tgggcatgt  ggatccagc  gagaaggat  aaaaaggca  gcccgtgac  gcccgtgtg  420
tattcattt  tggccctga  aagaaacta  aactgtcca  cctctaccc  gccaccacg  480
gcagaaact  tgatgagat  ctcagagtg  ttgactccc  ccagctgac  gcatcaaat  540
cagttgcca  tccagttga  tggaagaag  gagagagtg  gatggtcct  cccaccctc  600
ctgaagagg  agccaaaca  cttttccct  aaggagtct  caccaaaga  ctcccatct  660
gcaagaaat  cctccgtta  acgccccag  cttaagtct  cgggaactg  ggctgcaac  720
gctcgccca  cactgggac  tgaggatga  agctgacag  tgcagttcc  tagaaagat  780
gtggcgtgg  cacagccga  gtcgcgtag  tcgctcgct  tactactgg  tcattaaat  840
gaaatggca  caaaac  856



<210> 485
<211> 223
<212> PRT
<213> Rattus norvegicus
<308> O35244
<400> 485

Pro Gly Gly Leu Leu Leu Gly Asp Glu Ala Pro Asn Phe Glu Ala Asn 
  1               5                  10                  15
Thr Thr Ile Gly His Ile Arg Phe His Asp Phe Leu Gly Asp Ser Trp 
             20                  25                  30
Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr Thr 
         35                  40                  45
Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg Asn 
     50                  55                  60
Val Lys Leu Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Phe Ala 
 65                  70                  75                  80
Trp Ser Lys Asp Ile Asn Ala Tyr Asn Gly Ala Ala Pro Thr Glu Lys 
                 85                  90                  95
Leu Pro Phe Pro Ile Ile Asp Asp Lys Asp Arg Asp Leu Ala Ile Leu 
             100                105                110
Leu Gly Met Leu Asp Pro Ala Glu Lys Asp Glu Lys Gly Met Pro Val 
         115                120                125
Thr Ala Arg Val Val Phe Ile Phe Gly Pro Asp Lys Lys Leu Lys Leu 
     130                135                140
Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile Leu 
 145                150                155                160
Arg Val Val Asp Ser Leu Gln Leu Thr Ala Ser Asn Pro Val Ala Thr 
                 165                170                175
Pro Val Asp Trp Lys Lys Gly Glu Ser Val Met Val Leu Pro Thr Leu 
             180                185                190
Pro Glu Glu Glu Ala Lys Gln Leu Phe Pro Lys Gly Val Phe Thr Lys 
         195                200                205
Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 
     210                215                220



<210> 486
<211> 1653
<212> DNA
<213> Homo sapiens
<308> D14662
<400> 486

cggttgctt  ctgtcccag  ggcgccccc  catcaccgt  gccatgccc  gaggtctgc  60
tctcgggga  gtggctccc  actttgagg  caataccac  gtcggccgc  tccgtttcc  120
cgactttct  ggagactca  ggggcattc  cttctccca  cctcgggac  ttaccccag  180
gtgcaccac  gagcttggc  gagctgcaa  gctggcacc  gaatttgcc  agaggaatg  240
taagttgat  gccctttca  tagacagtg  tgaggacca  cttgcctgg  gcaaggata  300
caatgctta  aattgtgaa  agcccacag  aaagttacc  tttcccatc  tcgatgata  360
gaatcggga  cttgccatc  tgttgggca  gctggatcc  gcagagaag  atgaaaagg  420
catgcctgt  acagctcgt  tggtgtttg  ttttggtcc  gataagaag  tgaagctgt  480
tatcctcta  ccagctacc  ctggcagga  ctttgatga  attctcagg  tagtcatct  540
tctccagct  acagcagaa  aaagggttg  caccccagt  gattggaag  atggggata  600
tgtgatggt  cttccaacc  tccctgaag  agaagccaa  aaacttttc  cgaaaggag  660
cttcaccaa  gagctccca  ctggcaaga  atacctccg  tacacaccc  agccttaag  720
ctcttggag  agttggtgc  gtgagccag  ggatgtcag  tgccaattg  gttttcctg  780
agcaattcc  taaacacat  ctggtgtca  cacagccaa  gtttttagg  tgctatacc  840
atggcttat  aaatgaaaa  ggcactaaa  gtttcttga  attctttat  ctctctgcc  900
tcagcaatc  attccattc  tacatcagc  ctctgctgg  tctgtttga  atatgttct  960
tatttaaaa  tcaaatctt  ttggatctc  gcagggctt  tgaccaatg  agtcatatt  1020
gttgatggt  gacaaagct  gcttcactc  atcagagaa  gactatcaa  tttttttta  1080
ctgtcctat  acgtcctct  ctgtcaccc  ttttgaaga  tggcagaac  tgaagttca  1140
cttcctctg  aaatatcca  gtataaagc  caggaactt  tagaataac  cagatgcgc  1200
ttaattttt  ttaatatgt  ttgatcaca  aacttctag  ataacccag  tgctctttc  1260
tattctttt  atacatctt  atcacagct  ggggaaaaa  agcttttta  ttctgtacc  1320
tcctagtag  taagtgaag  gcagggaaa  agaccttta  atattttgc  ataaaaaaa  1380
ttgtgataa  tttctatca  aatggggag  ttgcagaaa  ggcttccct  ggctcccaa  1440
gaggtgtag  aggtgtgag  aatattagt  ccatgtgcc  ttcacacag  gtttgcatt  1500
atcagtctg  tttccgatg  tgtgtacat  aaagagtac  ccatgtgaa  agaagagag  1560
atgattgaa  atgttttag  atagaactc  tcttgcagt  ggttgctat  ttctagatt  1620
tacttttta  ggaacaaaa  aaaatcctt  gtt  1653



<210> 487
<211> 223
<212> PRT
<213> Homo sapiens
<308> P30041
<400> 487

Pro Gly Gly Leu Leu Leu Gly Asp Val Ala Pro Asn Phe Glu Ala Asn 
  1               5                  10                  15
Thr Thr Val Gly Arg Ile Arg Phe His Asp Phe Leu Gly Asp Ser Trp 
             20                  25                  30
Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr Thr 
         35                  40                  45
Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg Asn 
     50                  55                  60
Val Lys Leu Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Leu Ala 
 65                  70                  75                  80
Trp Ser Lys Asp Ile Asn Ala Tyr Asn Cys Glu Glu Pro Thr Glu Lys 
                 85                  90                  95
Leu Pro Phe Pro Ile Ile Asp Asp Arg Asn Arg Glu Leu Ala Ile Leu 
             100                105                110
Leu Gly Met Leu Asp Pro Ala Glu Lys Asp Glu Lys Gly Met Pro Val 
         115                120                125
Thr Ala Arg Val Val Phe Val Phe Gly Pro Asp Lys Lys Leu Lys Leu 
     130                135                140
Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile Leu 
 145                150                155                160
Arg Val Val Ile Ser Leu Gln Leu Thr Ala Glu Lys Arg Val Ala Thr 
                 165                170                175
Pro Val Asp Trp Lys Asp Gly Asp Ser Val Met Val Leu Pro Thr Ile 
             180                185                190
Pro Glu Glu Glu Ala Lys Lys Leu Phe Pro Lys Gly Val Phe Thr Lys 
         195                200                205
Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 
     210                215                220



<210> 488
<211> 602
<212> DNA
<213> Rattus norvegicus
<308> AF014503
<400> 488

gagggcaga  atttggaaa  caggcaaga  tttggagaa  gcagaccag  tatgatggc  60
accttgcca  caacagccc  cacttccca  caacctgta  acatagagg  cgaagatgg  120
atcctggat  agtatgacc  gtacagcct  gcccaatct  atgtcgtcg  tggaggtcg  180
aaaggacgt  ccaagagag  agctgctgc  aacaccaac  gccccagcc  tggtgggca  240
gagaggaag  tgctgacca  gttccagaa  tctgaaagg  aaaaggcct  gcgctgaga  300
agagctgga  atgaggcca  accacggac  ccacaccca  caatggata  aggaccttg  360
agaaattag  agttgtaag  aggacctag  cctgcttga  tctttccca  ctaagtgag  420
ctctggaga  ggaacacca  aaaaagccc  tccggaccc  gctaaaggg  aagttagga  480
cgagaagca  agggtagat  ggcagagct  agaaggcac  cccaaaaag  acagtggga  540
aaactggat  cccttgggt  gcagtaaca  taaactgta  aacagtgac  gcaaaaaaa  600
aa  602



<210> 489
<211> 80
<212> PRT
<213> Rattus norvegicus
<308> O54842
<400> 489

Met Ala Thr Leu Pro Pro Thr Ala His Thr Ser Gln Gln Pro Val Asn 
  1               5                  10                  15
Ile Glu Asp Glu Asp Gly Ile Leu Asp Glu Tyr Asp Gln Tyr Ser Leu 
             20                  25                  30
Ala Gln Ser Tyr Val Val Gly Gly Gly Arg Lys Gly Arg Thr Lys Arg 
         35                  40                  45
Glu Ala Ala Ala Asn Thr Asn Arg Pro Ser Pro Gly Gly His Glu Arg 
     50                  55                  60
Lys Leu Leu Thr Lys Phe Gln Asn Ser Glu Arg Lys Lys Ala Trp Arg 
 65                  70                  75                  80



<210> 490
<211> 719
<212> DNA
<213> Homo sapiens
<308> NM_012385
<400> 490

cagccttat  agctgaggg  gtggagagg  ccggggcca  gaaagcaga  acagacaaa  60
cgttaggag  agaagagag  cagggaaga  aagccaggc  cgatggcca  cttcccacc  120
gcaaccagc  ccccccagc  gcccccagg  ccggaggac  aggactcca  cctggatga  180
tctgacctc  atagcctgg  ccattccta  ctcggaggt  gaggccgga  aggtcgcac  240
aagagagaa  ctgctgcca  caccaaccg  cccagccct  gcgggcacg  gaggaaact  300
gtgaccaag  tgcagaatt  agagaggaa  aagcgaggg  cacggcgct  agacagagc  360
ggagatgag  ccagaccat  gacactaca  ccagcaata  agacgggac  gcggaggaa  420
gaggaccca  gacaggatc  aggccggct  gccacaccc  ccaccccta  gacttattc  480
cgctgactg  gtctctgag  ggctaccag  aaagcgcct  caaccctag  aaaagtgca  540
gatggggag  gagaggctg  gaatggagg  gcagagcca  gaagatccc  cagaaaaga  600
agctacaga  gaaactggg  ctcctccag  gtggcagca  caataaata  acacgcacg  660
cagccacag  ttgggtgtg  gttcatcct  gttaaaaaa  aaaaaaaaa  aaaaaaaaa  719



<210> 491
<211> 82
<212> PRT
<213> Homo sapiens
<308> O60356
<400> 491

Met Ala Thr Phe Pro Pro Ala Thr Ser Ala Pro Gln Gln Pro Pro Gly 
  1               5                  10                  15
Pro Glu Asp Glu Asp Ser Ser Leu Asp Glu Ser Asp Leu Tyr Ser Leu 
             20                  25                  30
Ala His Ser Tyr Leu Gly Gly Gly Gly Arg Lys Gly Arg Thr Lys Arg 
         35                  40                  45
Glu Ala Ala Ala Asn Thr Asn Arg Pro Ser Pro Gly Gly His Glu Arg 
     50                  55                  60
Lys Leu Val Thr Lys Leu Gln Asn Ser Glu Arg Lys Lys Arg Gly Ala 
 65                  70                  75                  80
Arg Arg 
                 85



<210> 492
<211> 1766
<212> DNA
<213> Rattus norvegicus
<308> AF015304
<400> 492

caccatgac  accagtcac  agcctcagg  caggtataa  gctgtctgg  tcatcttct  60
tgtcctggg  ctggggaca  tgctcccct  gaatttttt  ataacagca  cccagtatt  120
cacaagccg  ctgaacacg  cccagaata  atccttggt  accaaccaa  catgcgaaa  180
caccgaggc  ttggctgac  cctcagtgt  cttgccagc  cggagttct  tcagtgcca  240
cttcaacaa  gtcatgacc  tgtgtgcca  gttgccctt  ctgatcttc  cctgcctca  300
ctctttcct  catcagaag  tgtctcagt  ccttcggat  ttgggcagc  tgctggcta  360
cctgttggt  ttcctcgtc  ctgccaccc  ggtgaaggt  cagatggat  ccctgtcct  420
cttcatcat  accatgatc  agattgtgc  cattaactc  tttggtgcc  ttttgcaag  480
cagcctttt  ggtctggca  gcgtcctgc  ggccaacta  acagccccc  tcatgagtg  540
ccagggcct  gctggcttc  tcacctctg  tgccatgat  tgtgccgtc  ccagtggct  600
taagctgtc  gaaagtgct  ttggttact  catcacggc  tgtgcagtt  tcattctgg  660
catactgtg  tacctggcc  tgccttgga  ggaattcta  cgacattac  tgcagctca  720
ccttgcggg  cctgcagag  aggagacca  gttggatct  atcagtgaa  gagaggagc  780
aagaggagg  agagaggaa  ctggggtgc  aggccccaa  tctctaccc  ccaacagaa  840
ccaatccat  aaagccata  tgaagagta  ctgggtcct  gctctgtct  tctgtttca  900
cttcacagt  accattggg  tgttccctg  tgtgactgc  gaggtggaa  ccagcatcg  960
aggcacaag  ccctggaaa  actgctact  catccctgt  gcctgcttc  tgaatttca  1020
tgtctttga  tggctaggc  ggagcctca  agctatttg  atgtggcct  gtcaggaca  1080
ccgctggtt  ccggtcctg  tcgcctgca  ggttgtgtt  atccccctg  tgatgctct  1140
caatgtgaa  cagcaccac  acctgccct  cctctttaa  catgatgtc  ggttcatca  1200
cttcatggc  gcctttgcc  tctccaatg  ctacctcgc  agcctctgc  tgtgcttcg  1260
gcccaagaa  gtcaaaccg  ctgaggcag  gactgccgg  aacatcatg  ccttctttc  1320
gtgtctggg  ctggctctg  gagctgtgt  gtccttctt  ttaagggca  ttgtgtgag  1380
gaccctgtg  ggacagagg  actacactg  ctgcttcct  ctcacttcc  tcgctgtta  1440
ggacgagca  gggtccaga  ggctgctct  ctgctttcc  ccggtgctg  gcccagatg  1500
ccaggaaca  aggagggag  ctctgagga  ggacttggg  ttgggggtc  gagtggtag  1560
gggacaatg  tctctgacg  acagctctg  ctgatccct  cctaagcca  gcacaagag  1620
ctccacaag  atggggtgg  gacagatgg  tgactgtgt  tcatgatct  atgtccctt  1680
cccttcttt  ttctgtgcc  gttccaggt  cccgatcct  gtcatttta  tgccttttt  1740
atactgaca  aaaccaggt  ccttca  1766



<210> 493
<211> 456
<212> PRT
<213> Rattus norvegicus
<308> O54698
<400> 493

Thr Thr Ser His Gln Pro Gln Asp Arg Tyr Lys Ala Val Trp Leu Ile 
  1               5                  10                  15
Phe Phe Val Leu Gly Leu Gly Thr Leu Leu Pro Trp Asn Phe Phe Ile 
             20                  25                  30
Thr Ala Thr Gln Tyr Phe Thr Ser Arg Leu Asn Thr Ser Gln Asn Ile 
         35                  40                  45
Ser Leu Val Thr Asn Gln Ser Cys Glu Ser Thr Glu Ala Leu Ala Asp 
     50                  55                  60
Pro Ser Val Ser Leu Pro Ala Arg Ser Ser Leu Ser Ala Ile Phe Asn 
 65                  70                  75                  80
Asn Val Met Thr Leu Cys Ala Met Leu Pro Leu Leu Ile Phe Thr Cys 
                 85                  90                  95
Leu Asn Ser Phe Leu His Gln Lys Val Ser Gln Ser Leu Arg Ile Leu 
             100                105                110
Gly Ser Leu Leu Ala Ile Leu Leu Val Phe Leu Val Thr Ala Thr Leu 
         115                120                125
Val Lys Val Gln Met Asp Ala Leu Ser Phe Phe Ile Ile Thr Met Ile 
     130                135                140
Lys Ile Val Leu Ile Asn Ser Phe Gly Ala Ile Leu Gln Ala Ser Leu 
 145                150                155                160
Phe Gly Leu Ala Gly Val Leu Pro Ala Asn Tyr Thr Ala Pro Ile Met 
                 165                170                175
Ser Gly Gln Gly Leu Ala Gly Phe Phe Thr Ser Val Ala Met Ile Cys 
             180                185                190
Ala Val Ala Ser Gly Ser Lys Leu Ser Glu Ser Ala Phe Gly Tyr Phe 
         195                200                205
Ile Thr Ala Cys Ala Val Val Ile Leu Ala Ile Leu Cys Tyr Leu Ala 
     210                215                220
Leu Pro Trp Met Glu Phe Tyr Arg His Tyr Leu Gln Leu Asn Leu Ala 
 225                230                235                240
Gly Pro Ala Glu Gln Glu Thr Lys Leu Asp Leu Ile Ser Glu Gly Glu 
                 245                250                255
Glu Pro Arg Gly Gly Arg Glu Glu Ser Gly Val Pro Gly Pro Asn Ser 
             260                265                270
Leu Pro Ala Asn Arg Asn Gln Ser Ile Lys Ala Ile Leu Lys Ser Ile 
         275                280                285
Trp Val Leu Ala Leu Ser Val Cys Phe Ile Phe Thr Val Thr Ile Gly 
     290                295                300
Leu Phe Pro Ala Val Thr Ala Glu Val Glu Ser Ser Ile Ala Gly Thr 
 305                310                315                320
Ser Pro Trp Lys Asn Cys Tyr Phe Ile Pro Val Ala Cys Phe Leu Asn 
                 325                330                335
Phe Asn Val Phe Asp Trp Leu Gly Arg Ser Leu Thr Ala Ile Cys Met 
             340                345                350
Trp Pro Gly Gln Asp Ser Arg Trp Leu Pro Val Leu Val Ala Cys Arg 
         355                360                365
Val Val Phe Ile Pro Leu Leu Met Leu Cys Asn Val Lys Gln His His 
     370                375                380
Tyr Leu Pro Ser Leu Phe Lys His Asp Val Trp Phe Ile Thr Phe Met 
 385                390                395                400
Ala Ala Phe Ala Phe Ser Asn Gly Tyr Leu Ala Ser Leu Cys Met Cys 
                 405                410                415
Phe Gly Pro Lys Lys Val Lys Pro Ala Glu Ala Glu Thr Ala Gly Asn 
             420                425                430
Ile Met Ser Phe Phe Leu Cys Leu Gly Leu Ala Leu Gly Ala Val Leu 
         435                440                445
Ser Phe Leu Leu Arg Ala Leu Val 
     450                455



<210> 494
<211> 2162
<212> DNA
<213> Homo sapiens
<308> U81375
<400> 494

gggctgcgc  gtccagctg  ggctatggc  ccagccccg  gatgaggag  gagagaact  60
ggggcccgc  ggcctggga  tttccgtcc  ccaccaagt  cggatgctc  ctccaaagt  120
tcagcaggc  cctgaggga  ggagctgtc  gccagggaa  accgagaac  ccatcacca  180
gacaaccag  caccagcct  aggacagat  caaagctgt  tggcttatc  tcttcatgc  240
gggtctggg  acgctgctc  cgtggaatt  tttcatgac  gccactcag  atttcacaa  300
ccgcctgga  atgtcccag  atgtgtcct  ggtcactgc  gaactgagc  aggacgccc  360
ggcgtcagc  gcccctgca  cacccttgc  tgagcggaa  tctctcagt  ccatcttca  420
caatgtcat  accctatgt  ccatgctgc  cctgctgtt  ttcacctac  tcaactcct  480
cctgcatca  aggatcccc  agtccgtac  gatcctggg  agcctggtg  ccatcctgc  540
ggtgtttct  atcactgcc  tcctggtga  ggtgcagct  gatgctctg  ccttctttg  600
catcaccat  atcaagatc  tgctcatta  ttcatttgg  gccatcctg  agggcagcc  660
gtttggtct  gctggcctt  tgcctgcca  ctacacggc  cccatcatg  gtggccagg  720
cctagcagg  ttctttgcc  ccgtggcca  gatctgcgc  attgccagt  gctcggaac  780
atcagaaag  gccttcggc  actttatca  agcctgtgc  gttatcatt  tgaccatca  840
ctgttacct  ggcctgccc  gcctggaat  ctaccgcta  taccagcag  tcaagcttg  900
aggacccgg  gagcaggag  ccaagttgg  cctcattag  aaaggagag  agccaagag  960
aggcaaaga  gaatctgga  tttcagtct  caactctca  cccaccaat  aaagccact  1020
tatcaaagc  atcctgaaa  atatctcag  cctggcttt  tctgtctgc  tcatcttca  1080
tatcaccat  gggatgttt  cagccgtga  tgttgaggt  aagtccagc  tcgcaggca  1140
cagcacctg  gaacgttac  tcattcctg  gtcctgttt  ttgactttc  atatctttg  1200
ctggttggg  cggagcctc  cagctgtat  catgtggcc  gggaaggac  gccgctggc  1260
gccaagcct  gtgctggcc  ggctggtgt  tgtgccact  ctgctgctg  gcaacatta  1320
gccccgccg  tacctgact  tggtcttcg  gcacgatgc  tggttcatc  tcttcatgg  1380
tgcctttgc  ttctccaac  gctacctcg  cagcctctg  atgtgcttc  ggcccaaga  1440
agtgaagcc  gctgaggca  agaccgcag  agccatcat  gccttcttc  tgtgtctgg  1500
tctggcact  ggggctgtt  tctccttcc  gttccgggc  attgtgtga  aaaggatgg  1560
cagaaggac  gcctgcctc  ctccctgtc  gcctcctgc  ccttccttc  gccaggggt  1620
atcctgagt  gtctggcgg  tttttcttc  aactgactt  tgctttcca  ggcgtgtgc  1680
gggcccgga  ctccaggcc  tggggaggg  gcctctgga  ggacagtgg  gacattgtg  1740
gtttggggc  cagagtcga  ggacggggt  tagcctcgg  atttgcttg  gtttctcca  1800
tcttggctc  gactgatcc  tgcttgtgc  ggccagtgg  ggctcttgg  cttggagaa  1860
acgtgtgtc  ctgtgtatg  gtctgtgtg  ctgcgtccg  gtctgtcag  ctgtctgcc  1920
gtcctgggg  ggctaggag  tgggtctga  cgttgtatg  tttgacctg  tatactcca  1980
tctcccctg  gcctcctcc  ctgtgtttt  tccatgtcc  cctcccaac  ccccatgcc  2040
agtttttac  catcatgca  cctgtacag  tgccacgtt  ctgcctttt  taaaaatat  2100
tttgacaga  accaggtgc  ttcagaggc  ctctgattt  aataaacct  tcttgtttt  2160
tt  2162



<210> 495
<211> 455
<212> PRT
<213> Homo sapiens
<308> Q99808
<400> 495

Thr Thr Ser His Gln Pro Gln Asp Arg Tyr Lys Ala Val Trp Leu Ile 
  1               5                  10                  15
Phe Phe Met Leu Gly Leu Gly Thr Leu Leu Pro Trp Asn Phe Phe Met 
             20                  25                  30
Thr Ala Thr Gln Tyr Phe Thr Asn Arg Leu Asp Met Ser Gln Asn Val 
         35                  40                  45
Ser Leu Val Thr Ala Glu Leu Ser Lys Asp Ala Gln Ala Ser Ala Ala 
     50                  55                  60
Pro Ala Ala Pro Leu Pro Glu Arg Asn Ser Leu Ser Ala Ile Phe Asn 
 65                  70                  75                  80
Asn Val Met Thr Leu Cys Ala Met Leu Pro Leu Leu Leu Phe Thr Tyr 
                 85                  90                  95
Leu Asn Ser Phe Leu His Gln Arg Ile Pro Gln Ser Val Arg Ile Leu 
             100                105                110
Gly Ser Leu Val Ala Ile Leu Leu Val Phe Leu Ile Thr Ala Ile Leu 
         115                120                125
Val Lys Val Gln Leu Asp Ala Leu Pro Phe Phe Val Ile Thr Met Ile 
     130                135                140
Lys Ile Val Leu Ile Asn Ser Phe Gly Ala Ile Leu Gln Gly Ser Leu 
 145                150                155                160
Phe Gly Leu Ala Gly Leu Leu Pro Ala Ser Tyr Thr Ala Pro Ile Met 
                 165                170                175
Ser Gly Gln Gly Leu Ala Gly Phe Phe Ala Ser Val Ala Met Ile Cys 
             180                185                190
Ala Ile Ala Ser Gly Ser Glu Leu Ser Glu Ser Ala Phe Gly Tyr Phe 
         195                200                205
Ile Thr Ala Cys Ala Val Ile Ile Leu Thr Ile Ile Cys Tyr Leu Gly 
     210                215                220
Leu Pro Arg Leu Glu Phe Tyr Arg Tyr Tyr Gln Gln Leu Lys Leu Glu 
 225                230                235                240
Gly Pro Gly Glu Gln Glu Thr Lys Leu Asp Leu Ile Ser Lys Gly Glu 
                 245                250                255
Glu Pro Arg Ala Gly Lys Glu Glu Ser Gly Val Ser Val Ser Asn Ser 
             260                265                270
Gln Pro Thr Asn Glu Ser His Ser Ile Lys Ala Ile Leu Lys Asn Ile 
         275                280                285
Ser Val Leu Ala Phe Ser Val Cys Phe Ile Phe Thr Ile Thr Ile Gly 
     290                295                300
Met Phe Pro Ala Val Thr Val Glu Val Lys Ser Ser Ile Ala Gly Ser 
 305                310                315                320
Ser Thr Trp Glu Arg Tyr Phe Ile Pro Val Ser Cys Phe Leu Thr Phe 
                 325                330                335
Asn Ile Phe Asp Trp Leu Gly Arg Ser Leu Thr Ala Val Phe Met Trp 
             340                345                350
Pro Gly Lys Asp Ser Arg Trp Leu Pro Ser Leu Val Leu Ala Arg Leu 
         355                360                365
Val Phe Val Pro Leu Leu Leu Leu Cys Asn Ile Lys Pro Arg Arg Tyr 
     370                375                380
Leu Thr Val Val Phe Glu His Asp Ala Trp Phe Ile Phe Phe Met Ala 
 385                390                395                400
Ala Phe Ala Phe Ser Asn Gly Tyr Leu Ala Ser Leu Cys Met Cys Phe 
                 405                410                415
Gly Pro Lys Lys Val Lys Pro Ala Glu Ala Glu Thr Ala Gly Ala Ile 
             420                425                430
Met Ala Phe Phe Leu Cys Leu Gly Leu Ala Leu Gly Ala Val Phe Ser 
         435                440                445
Phe Leu Phe Arg Ala Ile Val 
     450                455



<210> 496
<211> 1678
<212> DNA
<213> Rattus norvegicus
<308> AF015305
<400> 496

ttacccaac  tgcaccctc  cactggcta  agcactccc  ccgaccttg  gattcccag  60
caccggcca  cgttgctgc  cttcggctt  ctagccctg  gtaggcgca  gtgcaacct  120
cctgcagtg  gcctggtgc  ataggactg  ggacatcat  gcgcacgga  acgcccctc  180
ggacagcta  cacctggtc  ggatcagct  cttcatttt  ggtctgggc  ccctcctcc  240
ctggaactt  ttcattacc  ccatcccgt  cttccaggg  cggttggca  ggaccaaca  300
cagcgctga  accccgagc  ccaaccaca  cagtcccac  gacaccttc  acttcaaca  360
ctgggtgac  ctgctgtcc  agctgcctc  actgctctt  acgctcctc  actccttct  420
gtatcagtg  atccctgag  cggtgcgta  tctgggcag  ctgctggcc  tactactgc  480
ctttgccct  acagcagcg  tggtgaagg  ggatttgag  cccgggctg  tcttttcca  540
caccatggc  tccgtctgg  tcatcaatt  cttctgtgc  gtgcttcaa  gcagcctct  600
tgggcagct  ggtaccatg  cttctacct  cagcaccct  ttcctcagt  gccagggcc  660
ggctgggat  ttcgctgcc  ttgctatgc  cacgtcctt  gccagtggc  tggaccccc  720
gacctctgc  cttgggtac  tcatcacac  ctgtgtggg  atcctcctc  ccatcatat  780
ttacctcag  ctgccccat  tgaagtttg  ccgttacta  ctgaccaag  agcctcagg  840
cccagttca  gagctggag  ccaaagctg  gctcctcgg  gctgatgag  agaatggga  900
tcctgtcag  ccccagcag  caggcccaa  tctggatct  gacccagag  aggagctgg  960
gctggggct  gaggaacca  agaagccag  aaaaccttc  gtctttgtc  tcttccgga  1020
gatctggct  acggcgctg  gccttgtgt  ggtcttcac  gtcaccctg  cggtctttc  1080
tgctatcac  gccatggtg  ccaccagct  caatagccc  gggaagtgg  gtcagttct  1140
caaccctat  tgttgcttc  tgctcttca  cgtcatgga  tggctgggc  ggagcctga  1200
ttcctactt  ctgtggcca  atgaggaca  ccagctgct  cccctgctg  tgtgcctgc  1260
cttcctgtt  gtgcccctc  tcatgctgt  tcatgtgcc  cagcgtgcc  ggctgccca  1320
catcttctg  caggatgcc  acttcatca  attcatgct  ctcttcgcc  tttccaacg  1380
ctacttcgt  tctctcacc  tgtgtctgg  acccaggca  gtgctgccg  atgagaggg  1440
ggtggccgg  gccctcatg  ccttcttcc  ggccctggg  ctctcctgc  gagcctctc  1500
ctccttcct  tttaaggct  tactctgag  accaccgca  tccacagtc  tccctcact  1560
ctgcttctg  agctggaca  tcccgggga  ggacctctg  tataccggg  ctcttggtc  1620
gtgggtgcc  ggagggggc  gaaactacc  tggctggta  ccacattgc  tatggtga  1678



<210> 497
<211> 456
<212> PRT
<213> Rattus norvegicus
<308> O54699
<400> 497

Met Ala His Gly Asn Ala Pro Arg Asp Ser Tyr His Leu Val Gly Ile 
  1               5                  10                  15
Ser Phe Phe Ile Leu Gly Leu Gly Thr Leu Leu Pro Trp Asn Phe Phe 
             20                  25                  30
Ile Thr Ala Ile Pro Tyr Phe Gln Gly Arg Leu Ala Gly Thr Asn Ser 
         35                  40                  45
Ser Ala Glu Thr Pro Ser Thr Asn His Thr Ser Pro Thr Asp Thr Phe 
     50                  55                  60
Asn Phe Asn Asn Trp Val Thr Leu Leu Ser Gln Leu Pro Leu Leu Leu 
 65                  70                  75                  80
Phe Thr Leu Leu Asn Ser Phe Leu Tyr Gln Cys Ile Pro Glu Ser Val 
                 85                  90                  95
Arg Ile Leu Gly Ser Leu Leu Ala Ile Leu Leu Leu Phe Ala Leu Thr 
             100                105                110
Ala Ala Leu Val Lys Val Asp Leu Ser Pro Gly Leu Phe Phe Ser Ile 
         115                120                125
Thr Met Ala Ser Val Trp Phe Ile Asn Ser Phe Cys Ala Val Leu Gln 
     130                135                140
Gly Ser Leu Phe Gly Gln Leu Gly Thr Met Pro Ser Thr Tyr Ser Thr 
 145                150                155                160
Leu Phe Leu Ser Gly Gln Gly Leu Ala Gly Ile Phe Ala Ala Leu Ala 
                 165                170                175
Met Leu Thr Ser Leu Ala Ser Gly Val Asp Pro Gln Thr Ser Ala Leu 
             180                185                190
Gly Tyr Phe Ile Thr Pro Cys Val Gly Ile Leu Leu Ser Ile Ile Cys 
         195                200                205
Tyr Leu Ser Leu Pro His Leu Lys Phe Ala Arg Tyr Tyr Leu Thr Lys 
     210                215                220
Lys Pro Gln Ala Pro Val Gln Glu Leu Glu Thr Lys Ala Glu Leu Leu 
 225                230                235                240
Gly Ala Asp Glu Lys Asn Gly Ile Pro Val Ser Pro Gln Gln Ala Gly 
                 245                250                255
Pro Thr Leu Asp Leu Asp Pro Glu Lys Glu Leu Glu Leu Gly Leu Glu 
             260                265                270
Glu Pro Gln Lys Pro Gly Lys Pro Ser Val Phe Val Val Phe Arg Lys 
         275                280                285
Ile Trp Leu Thr Ala Leu Cys Leu Val Leu Val Phe Thr Val Thr Leu 
     290                295                300
Ser Val Phe Pro Ala Ile Thr Ala Met Val Thr Thr Ser Ser Asn Ser 
 305                310                315                320
Pro Gly Lys Trp Ser Gln Phe Phe Asn Pro Ile Cys Cys Phe Leu Leu 
                 325                330                335
Phe Asn Val Met Asp Trp Leu Gly Arg Ser Leu Thr Ser Tyr Phe Leu 
             340                345                350
Trp Pro Asp Glu Asp Ser Gln Leu Leu Pro Leu Leu Val Cys Leu Arg 
         355                360                365
Phe Leu Phe Val Pro Leu Phe Met Leu Cys His Val Pro Gln Arg Ala 
     370                375                380
Arg Leu Pro Ile Ile Phe Trp Gln Asp Ala Tyr Phe Ile Thr Phe Met 
 385                390                395                400
Leu Leu Phe Ala Ile Ser Asn Gly Tyr Phe Val Ser Leu Thr Met Cys 
                 405                410                415
Leu Ala Pro Arg Gln Val Leu Pro His Glu Arg Glu Val Ala Gly Ala 
             420                425                430
Leu Met Thr Phe Phe Leu Ala Leu Gly Leu Ser Cys Gly Ala Ser Leu 
         435                440                445
Ser Phe Leu Phe Lys Ala Leu Leu 
     450                455



<210> 498
<211> 2522
<212> DNA
<213> Homo sapiens
<308> AF034102
<400> 498

ggatccgcg  tggcgcgac  ctctgtccc  gcctcgggg  ggagcccag  tcccagcct  60
cggagcgcg  gacacgccg  aatccgccc  aggctacct  tgcgactcc  gccgccctg  120
accggaatc  ggggagacc  gccccccgc  ccaccggtc  gcggccctc  gccccagcg  180
aggtgcagg  gcggcttct  tgccccttt  accccaggc  catccgccg  ggcggccat  240
gcgcgagga  acgccccgc  ggacagcta  cacctggtc  ggatcagct  cttcatcct  300
gggctgggc  ccctccttc  ctggaactt  ttcatcacc  ccatcccgt  cttccaggc  360
cgactggcc  gggccggca  cagcacagc  aggatcctg  gcaccaacc  cacgggtcc  420
gaggatgcc  tcaacttca  caattgggt  acgctgctg  cccagctgc  cctgctgct  480
ttcaccctc  tcaactcct  cctgtacca  tgcgtcccg  agacggtgc  cattctggg  540
agcctgctg  ccatactgc  gctctttgc  ctgacagca  cgctggtca  ggtggacat  600
agccccgga  ccttcttct  catcaccat  gcctccgtc  gcttcatca  ctccttcag  660
gcagtccta  agggcagcc  cttcgggca  ctgggcacc  tgccctcca  ctacagcac  720
ctcttcctc  gcggccagg  cctggctgg  atctttgct  cccttgcca  gctcctgtc  780
atggccagt  gcgtggacg  cgagacctc  gccctgggg  actttatca  gccctgtgt  840
ggcatcctc  tgtccatcg  gtgttacct  agcctgcct  acctgaagt  tgcccgcta  900
tacctggcc  ataaatcat  ccaggccca  gctcaggag  tggagacca  agctgagct  960
ctccagtct  atgagaacg  gattcccag  agtccccag  aagtagctc  gaccctgga  1020
cttgacctg  agaaggagc  ggaatcaga  ccagatgag  cccagaagc  aggaaaacc  1080
tcagtcttc  ctgtcttcc  gaagatctg  ctgacagcg  tgtgccttg  gttggtctt  1140
acagtcacc  tgtccgtct  ccccgccat  acagccatg  tgaccagct  caccagtcc  1200
gggaagtgg  gtcagttct  caaccccat  tgctgcttc  tcctcttca  catcatgga  1260
tggctggga  ggagcctga  ctcttactt  ctgtggcca  acgaggaca  ccggctgct  1320
cccctgctg  tctgcctgc  gttcctgtt  gtgcccctc  tcatgctgt  ccacgtgcc  1380
cagaggtcc  ggctgccca  cctcttccc  caggatgcc  acttcatca  cttcatgct  1440
ctctttgcc  tttctaatg  ctacctggt  tccctcacc  tgtgcctgg  gcccaggca  1500
gtgctgcca  acgagaggg  ggtggccgg  gccctcatg  ccttcttcc  ggccctggg  1560
ctttcctgt  gagcctccc  ctccttcct  ttcaaggcg  tgctctgaa  tggcccctc  1620
aggctcttt  gcagcctct  ctcgacgtc  ccttccgga  ctgagatcc  gcccagggc  1680
aatggcgag  ttggctcag  cctctgcgg  gtggaggcc  ctgggcctg  ggctgccag  1740
agcgggcag  agctgctct  catccactt  gagtgctgc  gggaagaaa  caccaccgg  1800
cattctaac  ctcacccag  aatgggggt  actcgcaca  gacctcatg  aaagggtga  1860
gactaggga  aagagggtg  agggcacgg  tgctcccca  caccaggtc  gcatttgtt  1920
atcatcatc  ggagcagag  tgaccagag  gttcagagt  ggaggcagg  ccagcccag  1980
ccaggagcg  ctcatcttc  caggcctca  ccacccagg  taaaaggtg  cagggaagt  2040
gtgggcacc  gagaggagg  acagatgtg  aggacctga  ggtgctcaa  gggccaggc  2100
cagcctcaa  cagtgtttt  attgccaac  cttactgta  ccactccgc  gagccccgc  2160
gggcctggg  cccagggcc  cagctagcc  gcatgtgtg  actgcactt  acagtttgc  2220
aagctcttc  atacccact  tctcaccga  gcctaattg  ggctcttgg  aggagtcag  2280
caaggattg  gcttccccc  ttatacagg  gacaaaact  agtcctggg  aaagtgact  2340
gtccgtggt  gagccggga  ccaatcccc  ctctctcct  cctgttggt  ctgttcttc  2400
tgcccaaca  ctgtttctc  tttcctcaa  gggtttggg  caggagcct  ggcacttac  2460
ccccgtttt  gctgtttct  cttctgacc  tgctcttgg  tctaataac  ccatttatt  2520
gt  2522



<210> 499
<211> 456
<212> PRT
<213> Homo sapiens
<308> Q14542
<400> 499

Met Ala Arg Gly Asp Ala Pro Arg Asp Ser Tyr His Leu Val Gly Ile 
  1               5                  10                  15
Ser Phe Phe Ile Leu Gly Leu Gly Thr Leu Leu Pro Trp Asn Phe Phe 
             20                  25                  30
Ile Thr Ala Ile Pro Tyr Phe Gln Ala Arg Leu Ala Gly Ala Gly Asn 
         35                  40                  45
Ser Thr Ala Arg Ile Leu Ser Thr Asn His Thr Gly Pro Glu Asp Ala 
     50                  55                  60
Phe Asn Phe Asn Asn Trp Val Thr Leu Leu Ser Gln Leu Pro Leu Leu 
 65                  70                  75                  80
Leu Phe Thr Leu Leu Asn Ser Phe Leu Tyr Gln Cys Val Pro Glu Thr 
                 85                  90                  95
Val Arg Ile Leu Gly Ser Leu Leu Ala Ile Leu Leu Leu Phe Ala Leu 
             100                105                110
Thr Ala Ala Leu Val Lys Val Asp Met Ser Pro Gly Pro Phe Phe Ser 
         115                120                125
Ile Thr Met Ala Ser Val Cys Phe Ile Asn Ser Phe Ser Ala Val Leu 
     130                135                140
Gln Gly Ser Leu Phe Gly Gln Leu Gly Thr Met Pro Ser Thr Tyr Ser 
 145                150                155                160
Thr Leu Phe Leu Ser Gly Gln Gly Leu Ala Gly Ile Phe Ala Ala Leu 
                 165                170                175
Ala Met Leu Leu Ser Met Ala Ser Gly Val Asp Ala Glu Thr Ser Ala 
             180                185                190
Leu Gly Tyr Phe Ile Thr Pro Tyr Val Gly Ile Leu Met Ser Ile Val 
         195                200                205
Cys Tyr Leu Ser Leu Pro His Leu Lys Phe Ala Arg Tyr Tyr Leu Ala 
     210                215                220
Asn Lys Ser Ser Gln Ala Gln Ala Gln Glu Leu Glu Thr Lys Ala Glu 
 225                230                235                240
Leu Leu Gln Ser Asp Glu Asn Gly Ile Pro Ser Ser Pro Gln Lys Val 
                 245                250                255
Ala Leu Thr Leu Asp Leu Asp Leu Glu Lys Glu Pro Glu Ser Glu Pro 
             260                265                270
Asp Glu Pro Gln Lys Pro Gly Lys Pro Ser Val Phe Thr Val Phe Gln 
         275                280                285
Lys Ile Trp Leu Thr Ala Leu Cys Leu Val Leu Val Phe Thr Val Thr 
     290                295                300
Leu Ser Val Phe Pro Ala Ile Thr Ala Met Val Thr Ser Ser Thr Ser 
 305                310                315                320
Pro Gly Lys Trp Ser Gln Phe Phe Asn Pro Ile Cys Cys Phe Leu Leu 
                 325                330                335
Phe Asn Ile Met Asp Trp Leu Gly Arg Ser Leu Thr Ser Tyr Phe Leu 
             340                345                350
Trp Pro Asp Glu Asp Ser Arg Leu Leu Pro Leu Leu Val Cys Leu Arg 
         355                360                365
Phe Leu Phe Val Pro Leu Phe Met Leu Cys His Val Pro Gln Arg Ser 
     370                375                380
Arg Leu Pro Ile Leu Phe Pro Gln Asp Ala Tyr Phe Ile Thr Phe Met 
 385                390                395                400
Leu Leu Phe Ala Val Ser Asn Gly Tyr Leu Val Ser Leu Thr Met Cys 
                 405                410                415
Leu Ala Pro Arg Gln Val Leu Pro His Glu Arg Glu Val Ala Gly Ala 
             420                425                430
Leu Met Thr Phe Phe Leu Ala Leu Gly Leu Ser Cys Gly Ala Ser Leu 
         435                440                445
Ser Phe Leu Phe Lys Ala Leu Leu 
     450                455



<210> 500
<211> 489
<212> DNA
<213> Rattus norvegicus
<308> AF015719
<400> 500

atgaaaatt  tgaaaccat  tatgaggaa  acatccatc  tgtactacc  gtgtttcct  60
ctcaacagt  acttcttaa  tgaggctgg  atccatgtc  tcattttgg  ctgtgtcag  120
gtaggtctc  ctaaaacag  ggccaactg  atagatgta  gatacgatc  ggagaaaat  180
gaaagtctt  ttcaattta  tcatattga  actactcta  acactgaca  tgactttca  240
cccagttgc  aagttactg  aatgaactg  tttctcctg  aattacagg  tattttgca  300
gagtacagt  acatgactc  taatgaaac  gtaagaaac  tgctctacc  tgcaaacag  360
actctgtct  ctaacaaga  tgtaataga  tctggctgc  aggaatgtg  ggagctgga  420
gagagaaac  tcacggagt  tttgcagag  tttatacat  ttgtccaaa  gttcatcaa  480
acgtcctga  489



<210> 501
<211> 162
<212> PRT
<213> Rattus norvegicus
<308> P97604
<400> 501

Met Lys Ile Leu Lys Pro Tyr Met Arg Asn Thr Ser Ile Leu Tyr Tyr 
  1               5                  10                  15
Leu Cys Phe Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
             20                  25                  30
Val Phe Ile Leu Gly Cys Val Ser Val Gly Leu Pro Lys Thr Glu Ala 
         35                  40                  45
Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu Ile 
     50                  55                  60
Gln Phe Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe His 
 65                  70                  75                  80
Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu Glu Leu Gln 
                 85                  90                  95
Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu Thr Val Arg 
             100                105                110
Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn Val 
         115                120                125
Ile Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Arg Asn Phe 
     130                135                140
Thr Glu Phe Leu Gln Ser Phe Ile His Ile Val Gln Met Phe Ile Asn 
 145                150                155                160
Thr Ser 
                 165



<210> 502
<211> 486
<212> DNA
<213> Homo sapiens
<308> Y09908
<400> 502

cggattggg  tcggaccta  ttgattcac  tctgggaaa  caaggatct  cgtaccatg  60
attttcagg  gcagatttt  agcttcctg  taatcagtg  ctcagtcat  atgtctaga  120
ccaactggg  gaatgtaat  agtgatttg  aaaaaattg  agatcttat  caatctatg  180
atattgatg  tactttata  acggaaagt  atgttcacc  cagttgcaa  gtaacagca  240
tgaagtgct  tctcttgga  ttacaagtt  tttcacttg  gtccggaga  gcaagtatt  300
atgatacag  agaaaatct  atcatccta  caaacaaca  tttgtcttc  aatgggaat  360
taacagaat  tggatgcaa  gaatgtgag  aactggagg  aaaaaatat  aaagaattt  420
tgcagagtt  tgtacatat  gtccaaatg  tcatcaaca  ttcttgatt  caattgatt  480
ctcgag  486



<210> 503
<211> 162
<212> PRT
<213> Homo sapiens
<308> P40933
<400> 503

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
  1               5                  10                  15
Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
             20                  25                  30
Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
         35                  40                  45
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
     50                  55                  60
Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
 65                  70                  75                  80
Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                 85                  90                  95
Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
             100                105                110
Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
         115                120                125
Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
     130                135                140
Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
 145                150                155                160
Thr Ser 
                 165



<210> 504
<211> 865
<212> DNA
<213> Rattus norvegicus
<308> AF016047
<400> 504

ggagggagg  gcgctaaat  gtctctggt  cctgtcggc  tttcaggag  tgcggtgct  60
aggatgagc  gggaagggg  gaacccggc  agcaagccc  cgcctgtgc  ggacgtgca  120
ggcgacgga  gctggatgt  tctgcacca  cgatttgtg  cagacagca  agacaagga  180
cccgaagtc  tctttatcg  ggactcctt  gttcagcta  tgcatcagt  tgagatctg  240
cgggagctc  tctcacctc  gcatgcact  aactttggc  ttggcggtg  cagcacaca  300
catgtactc  ggcggcttg  gaatgggga  ctggagcac  tccggccca  gattgtggt  360
gtctgggtg  gcaccaaca  ccacagcca  acagcagaa  aagtgacag  tggcatcaa  420
gccattgta  aactggtga  caagctgca  ccccaggcc  gggtggttg  gctgggcct  480
cttccaaga  gccagcacc  caacccact  cgagagaaa  accgacagg  gaacgagct  540
gttcgggca  cactagctg  ctacccccg  gcgcacttc  tagatgcag  ccctggctt  600
gtgcactcg  acggtacca  aagtcacca  gacatgtat  actacctgc  cctgagccg  660
ctggggtac  cacctgtct  ccgggccct  cactccttg  tgcttcgtc  cctggccca  720
gatcagggc  aaggcatcc  tctgccaga  acagcaccc  aagcatctt  ccttccttc  780
cttgacaat  aattctcct  ttccaccta  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  840
aaaaataaa  taaaaaaaa  aaaaa  865



<210> 505
<211> 232
<212> PRT
<213> Rattus norvegicus
<308> O35263
<400> 505

Met Ser Gly Glu Gly Glu Asn Pro Ala Ser Lys Pro Thr Pro Val Gln 
  1               5                  10                  15
Asp Val Gln Gly Asp Gly Arg Trp Met Ser Leu His His Arg Phe Val 
             20                  25                  30
Ala Asp Ser Lys Asp Lys Glu Pro Glu Val Val Phe Ile Gly Asp Ser 
         35                  40                  45
Leu Val Gln Leu Met His Gln Cys Glu Ile Trp Arg Glu Leu Phe Ser 
     50                  55                  60
Pro Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Ser Thr Gln His 
 65                  70                  75                  80
Val Leu Trp Arg Leu Glu Asn Gly Glu Leu Glu His Ile Arg Pro Lys 
                 85                  90                  95
Ile Val Val Val Trp Val Gly Thr Asn Asn His Ser His Thr Ala Glu 
             100                105                110
Gln Val Thr Gly Gly Ile Lys Ala Ile Val Gln Leu Val Asn Lys Leu 
         115                120                125
Gln Pro Gln Ala Arg Val Val Val Leu Gly Leu Leu Pro Arg Gly Gln 
     130                135                140
His Pro Asn Pro Leu Arg Glu Lys Asn Arg Gln Val Asn Glu Leu Val 
 145                150                155                160
Arg Ala Ala Leu Ala Gly Tyr Pro Arg Ala His Phe Leu Asp Ala Asp 
                 165                170                175
Pro Gly Phe Val His Ser Asp Gly Thr Ile Ser His His Asp Met Tyr 
             180                185                190
Asp Tyr Leu His Leu Ser Arg Leu Gly Tyr Thr Pro Val Cys Arg Ala 
         195                200                205
Leu His Ser Leu Leu Leu Arg Leu Leu Ala Gln Asp Gln Gly Gln Gly 
     210                215                220
Ile Pro Leu Pro Glu Thr Ala Pro 
 225                230



<210> 506
<211> 852
<212> DNA
<213> Homo sapiens
<308> D63391
<400> 506

ggacggtcc  ttgttgccg  gaggggtag  agtgggcgt  gcggagcca  ctccgttcg  60
aacactccc  ggccgaccc  actcgctca  cctgcagga  ctgcggcgc  aagatgagt  120
gagaggaga  cccagccag  aagcccacg  cggtgcagg  cgtacaggg  gacgggcgc  180
ggatgtccc  gcaccatcg  ttcgtggct  acagcaaag  taaggaacc  gaagtcgtc  240
tcatcgggg  ctccttggt  cagctcatg  accagtgcg  gatctggcg  gagctcttc  300
ctcctctgc  tgcacttaa  tttggcatt  gtggtgacg  cacacagca  gtactgtgg  360
ggctggaga  tggggagct  gaacacatc  ggcccaaga  tgtggtggt  tgggtgggc  420
ccaacaacc  cggacacac  gcagagcag  tgactggtg  catcaaggc  attgtgcaa  480
tggtgaatg  gcgacagcc  caggcccgg  ttgtggtgc  gggcctgct  ccgcgaggc  540
aacatccca  cccacttcg  gagaagaac  gacaggtga  cgagctggt  cgggcggca  600
tggctggcc  ccctcgggc  cacttccta  atgccgacc  tggctttgt  cactcagat  660
gcaccatca  ccatcatga  atgtatgat  acctgcatc  gagccgcct  ggctacaca  720
ctgtttgcc  ggctctgca  tccctgctt  tgcgtctgc  ggcccaaga  cagggccaa  780
gtgctcccc  gctggagcc  gcaccctaa  catcctgct  ccttcccac  acattaaac  840
ctccttcct  ag  852



<210> 507
<211> 231
<212> PRT
<213> Homo sapiens
<308> Q15102
<400> 507

Met Ser Gly Glu Glu Asn Pro Ala Ser Lys Pro Thr Pro Val Gln Asp 
  1               5                  10                  15
Val Gln Gly Asp Gly Arg Trp Met Ser Leu His His Arg Phe Val Ala 
             20                  25                  30
Asp Ser Lys Asp Lys Glu Pro Glu Val Val Phe Ile Gly Asp Ser Leu 
         35                  40                  45
Val Gln Leu Met His Gln Cys Glu Ile Trp Arg Glu Leu Phe Ser Pro 
     50                  55                  60
Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Gly Thr Gln His Val 
 65                  70                  75                  80
Leu Trp Arg Leu Glu Asn Gly Glu Leu Glu His Ile Arg Pro Lys Ile 
                 85                  90                  95
Val Val Val Trp Val Gly Thr Asn Asn His Gly His Thr Ala Glu Gln 
             100                105                110
Val Thr Gly Gly Ile Lys Ala Ile Val Gln Leu Val Asn Glu Arg Gln 
         115                120                125
Pro Gln Ala Arg Val Val Val Leu Gly Leu Leu Pro Arg Gly Gln His 
     130                135                140
Pro Asn Pro Leu Arg Glu Lys Asn Arg Gln Val Asn Glu Leu Val Arg 
 145                150                155                160
Ala Ala Leu Ala Gly His Pro Arg Ala His Phe Leu Asp Ala Asp Pro 
                 165                170                175
Gly Phe Val His Ser Asp Gly Thr Ile Ser His His Asp Met Tyr Asp 
             180                185                190
Tyr Leu His Leu Ser Arg Leu Gly Tyr Thr Pro Val Cys Arg Ala Leu 
         195                200                205
His Ser Leu Leu Leu Arg Leu Leu Ala Gln Asp Gln Gly Gln Gly Ala 
     210                215                220
Pro Leu Leu Glu Pro Ala Pro 
 225                230



<210> 508
<211> 4505
<212> DNA
<213> Rattus norvegicus
<308> AF016252
<400> 508

ggggaggga  ggagggagg  aggtgcggc  gagcggccc  ggttagcgg  gcagccacg  60
gcgcgggga  gccgggcat  ccgagagcc  aggcccccg  ccggagtag  gggcgcctg  120
gccgccagc  ccgctgaca  cgcctcgga  gatgtgagc  ggtgccgcg  ccgctgctt  180
gcgggctgg  cgcgcggtc  cagcggctc  agccagcct  cgcttcttt  atttgggtg  240
gggcgaacg  accaggccg  tagatcttt  gaagggggc  ggctgtctt  ggcagcttg  300
ttgggggag  cgacccaca  agggcgctc  gagattttt  ttttttaaa  cagggttaa  360
tgttttttg  cagcttgat  tctggggga  tctatagaa  gcctttcgg  atttctttc  420
ttgggggga  ggggcggtg  tcccgactt  gccagccgc  tgctggagg  ggacagcgg  480
gagcagggg  atgcgaacc  ggctccccc  accatgatg  agacggagc  tcgggggcc  540
gggggtccc  tccggagcg  ctccccgca  cgcagcgcc  acgaagcgg  catccaggc  600
ctaaagcct  ccgatgctc  cgggcctga  gaggcaccc  aggcggccc  ccataagaa  660
tatggctcc  acgtccacc  catcaaaag  atgttcctg  agatgggca  caccacggg  720
ccgccgggt  aggcaggcg  cgcctcagg  atggccgaa  ccccacggg  gtccgatcg  780
ggcgtgcgc  tttccctgc  gcgggccag  agcctgaac  agaacgtgg  ccacagtgc  840
ctgctcaag  tgggcacca  tgtgtcgga  cgcgtgagc  gtttcgact  caagcccgc  900
ccctcggcg  agccggctc  gccgccgca  ccgccgtcc  ggctgcagg  gacgcggaa  960
ctgttcgaa  ggagcgtcc  cgcggcctc  ggtggcgac  aggaggccg  ggcgcggcg  1020
ctgctgagg  aggagcgcg  cagcctgca  gaccggaag  tggacgtcg  ggtgcgctt  1080
aacggcagc  ccgaggcgc  ggacaagct  gatgctgac  ccgtgtcgc  gacggtcag  1140
cagctcagt  cggtcttcg  gaaagccga  tcgaggacc  gccttcacc  tgcacccgg  1200
ccccctcgg  ccgcggggg  gccccaggt  aactcgaag  tggtcacca  gcggtcccg  1260
gtgttccag  caccgccgc  gcctcccgc  ccgtcgggg  atgccgcga  agagaagga  1320
cgtggcccc  gagggcagc  gcccccaca  caccgagtg  cccctgccc  acctccgcc  1380
aagccgcgg  aggtacgca  gatcaaacc  gtggaggtt  aggaaagtg  ggagtctga  1440
gctgagtcg  ctcccgggg  agtgatcca  gccgaggtg  ccgtccatg  agccttgga  1500
aatggcagc  ccacagcca  cacagccag  cctgcaccc  aggaaccca  ggccgaagc  1560
gtccccgaa  aggaggcgt  gtcgtcagt  gcgacacta  agagggggg  ggacaatgg  1620
cgggccccg  acatggcac  cgaggaggt  gatgaatcc  aaaaggagg  cttctcaga  1680
gcggacttg  tagacgtga  cgcctacag  ggactcggg  aggactctg  gggcagtgc  1740
ctggaagag  acgatgaag  agatgaaga  gacggggag  ccccctacg  gccggaatc  1800
gggtgtgtg  agattcctg  gctttcaga  gaagaggac  cagccccga  ccggaagat  1860
catttcagc  ccgcaccga  ccaagtatt  agcacctac  ccaatgagg  ctatgaccg  1920
cgcaatgag  atgtggacc  catggcggc  tctgcggaa  acgagctgg  gaagcgagt  1980
gagaggttg  agctgtttc  tgtggagtt  gagaaggac  ctgagggcc  gggcatcag  2040
atcattggc  tgggagccg  agccgacat  ggcctggag  agctgggca  cttcgtcaa  2100
actgtgact  agggtggtg  agcccatcg  gatggcagg  tccaagtga  cgatctcct  2160
gtagaggtg  acgggacga  cctggtggg  gtgacccag  gctttgcag  ctctgtgct  2220
aggaacacc  aaggcagag  gcggttcat  attggccgg  agcggcctg  agaacagag  2280
gaagtggcc  agctaattc  gcagacctt  gagcaggag  ggtggcagc  ggagatgat  2340
gagcagaga  acgcccagt  tggagaaga  gatgaggag  caggagagt  tgccaccga  2400
gaagatgaa  aactgagcc  gacatttcc  gggggtgaa  tggccatcg  ggtgtttga  2460
ctagcagag  atgaggatg  actgtcccc  gtggagatg  agcctgaaa  gctggtgca  2520
aagttcaag  agctccaga  caagcatgc  gtcactgaa  cggaaatcc  gcagctgaa  2580
cggaagttg  agagtctgg  gcaggagaa  gggcgctgg  gggtggaga  ggcccagct  2640
gagcagagt  tggaggaga  taaggagcg  atggagaag  tagaaggct  ctggggtga  2700
gcccagagc  tgtgccagg  tgtggatga  cacctgcgg  agactcagg  ccagtatca  2760
gccctggag  gaaagtaca  caaggccaa  cgtctcatc  aggactacc  gcaaaagga  2820
atcgagttc  tgaaaaaag  gaccgccca  cgtcgggta  tggaagagt  ggagctagc  2880
aggaaggag  aaatggaca  acttctgga  aagatctca  aactggaag  aaacctgca  2940
acactgagg  attccaatt  tacttaaca  gaatccttg  ctggacaat  ataacccct  3000
cattatcct  accccctgt  ctcaatcct  accccaccc  taccagcct  gggacaggt  3060
ccccgactt  ccctactcc  ccaccccat  tcccccagc  tcagggacc  gagggccca  3120
attacaggc  cctttaggg  ggccagggc  gacaatgct  gctggaaga  tggcctcct  3180
gccctgtgg  gctgaggca  agaggccga  agaagctaa  agctggcct  ggtggtgga  3240
ggacacaag  acctgcaga  caaactgcc  gactttata  cctccagcc  gtgtctctg  3300
accggagtg  agctggggc  ctcccagca  ctcaccact  ggaggctgc  ccctgccca  3360
agggtccgt  tggcccctg  gcctcttga  ttgagattc  tggcccctt  ctcttcccc  3420
tcattgtgc  gtctgttgc  ttctggcct  caacttgga  ggattgcct  aacatctcc  3480
acccctgct  cccatccca  gagggatag  gcccaccct  gagccggag  ctgggcctg  3540
tcctgcact  atatctctc  tatccttca  gggggaagg  gaatgtgac  aggggaaag  3600
gtagtccag  acacctgga  tccagcccc  cttcctagg  agggcagca  ccctcaact  3660
ctccgtgtg  ctcccctct  ccaggtgcc  aacagccat  ggcctcctc  tggaactgc  3720
ctgaggcca  tctggggtt  ggggtttcc  tggtctagc  taggaatgc  aggagggag  3780
gaggtcagc  taggtggtg  gcctgcaga  ctctcactg  agagctagg  cctacccag  3840
gccacaccc  gaagccttg  attaacatc  aagagactc  gcctcccct  ctccactcc  3900
ccactgttt  ccaatgttt  cactggagg  caaaatttt  ctactcatc  ttctggaga  3960
cagggctgc  tactgtcag  ctgctttct  agtgaaatt  actccattt  cccacgtta  4020
ccccaaatt  gggcttgga  caagggagg  gagaaccct  aggtaccct  ccctttcag  4080
atccatctc  tgccacttc  acataccac  ccggcccta  gcctaactt  gttttattt  4140
ttttttctt  tttttaaaa  aacccagtt  tatcctttt  ggtttctcc  agtcccctg  4200
aaatagacc  taccatcaa  cagtatttc  tgcccctct  ttcctcccc  cgacgtgcc  4260
ctactcccc  gaaagagct  gctgtcaca  tgcccggcc  ctgcacttc  cccaggcag  4320
tggaggggg  ggagccggg  gggcgggcc  tcggtgtac  tccggtttt  accggcagc  4380
ctcctgccc  gcccttgga  gacccgtct  tgtatataa  atatatatg  atgtattgt  4440
cctggtttt  tacggacca  gccctctgt  aggtcgtcc  cataaaagc  gcccccaga  4500
aaaaa  4505



<210> 509
<211> 817
<212> PRT
<213> Rattus norvegicus
<308> O35274
<400> 509

Met Met Lys Thr Glu Pro Arg Gly Pro Gly Gly Pro Leu Arg Ser Ala 
  1               5                  10                  15
Ser Pro His Arg Ser Ala Tyr Glu Ala Gly Ile Gln Ala Leu Lys Pro 
             20                  25                  30
Pro Asp Ala Pro Gly Pro Asp Glu Ala Pro Lys Ala Ala His His Lys 
         35                  40                  45
Lys Tyr Gly Ser Asn Val His Arg Ile Lys Ser Met Phe Leu Gln Met 
     50                  55                  60
Gly Thr Thr Thr Gly Pro Pro Gly Glu Ala Gly Gly Ala Ser Gly Met 
 65                  70                  75                  80
Ala Glu Ala Pro Arg Ala Ser Asp Arg Gly Val Arg Leu Ser Leu Pro 
                 85                  90                  95
Arg Ala Ser Ser Leu Asn Glu Asn Val Asp His Ser Ala Leu Leu Lys 
             100                105                110
Leu Gly Thr Ser Val Ser Glu Arg Val Ser Arg Phe Asp Ser Lys Pro 
         115                120                125
Ala Pro Ser Ala Gln Pro Ala Pro Pro Pro His Pro Pro Ser Arg Leu 
     130                135                140
Gln Glu Thr Arg Lys Leu Phe Glu Arg Ser Val Pro Ala Ala Ser Gly 
 145                150                155                160
Gly Asp Lys Glu Ala Val Ala Arg Arg Leu Leu Arg Gln Glu Arg Ala 
                 165                170                175
Ser Leu Gln Asp Arg Lys Leu Asp Val Val Val Arg Phe Asn Gly Ser 
             180                185                190
Thr Glu Ala Leu Asp Lys Leu Asp Ala Asp Ala Val Ser Pro Thr Val 
         195                200                205
Ser Gln Leu Ser Ala Val Phe Glu Lys Ala Asp Ser Arg Thr Gly Leu 
     210                215                220
His Arg Ala Pro Gly Pro Pro Arg Ala Ala Gly Ala Pro Gln Val Asn 
 225                230                235                240
Ser Lys Leu Val Thr Lys Arg Ser Arg Val Phe Gln Pro Pro Pro Pro 
                 245                250                255
Pro Pro Ala Pro Ser Gly Asp Ala Ala Thr Glu Lys Asp Arg Gly Pro 
             260                265                270
Gly Gly Gln Gln Pro Pro Gln His Arg Val Ala Pro Ala Arg Pro Pro 
         275                280                285
Pro Lys Pro Arg Glu Val Arg Lys Ile Lys Pro Val Glu Val Glu Glu 
     290                295                300
Ser Gly Glu Ser Glu Ala Glu Ser Ala Pro Gly Glu Val Ile Gln Ala 
 305                310                315                320
Glu Val Thr Val His Ala Ala Leu Glu Asn Gly Ser Thr Thr Ala Thr 
                 325                330                335
Thr Ala Ser Pro Ala Pro Glu Glu Pro Lys Ala Glu Ala Val Pro Glu 
             340                345                350
Glu Glu Ala Ser Ser Ser Val Ala Thr Leu Glu Arg Gly Val Asp Asn 
         355                360                365
Gly Arg Ala Pro Asp Met Ala Pro Glu Glu Val Asp Glu Ser Lys Lys 
     370                375                380
Glu Asp Phe Ser Glu Ala Asp Leu Val Asp Val Ser Ala Tyr Ser Gly 
 385                390                395                400
Leu Gly Glu Asp Ser Gly Gly Ser Ala Leu Glu Glu Asp Asp Glu Glu 
                 405                410                415
Asp Glu Glu Asp Gly Glu Pro Pro Tyr Glu Pro Glu Ser Gly Cys Val 
             420                425                430
Glu Ile Pro Gly Leu Ser Glu Glu Glu Asp Pro Ala Pro Ser Arg Lys 
         435                440                445
Ile His Phe Ser Thr Ala Pro Ile Gln Val Phe Ser Thr Tyr Ser Asn 
     450                455                460
Glu Asp Tyr Asp Arg Arg Asn Glu Asp Val Asp Pro Met Ala Ala Ser 
 465                470                475                480
Ala Glu Tyr Glu Leu Glu Lys Arg Val Glu Arg Leu Glu Leu Phe Pro 
                 485                490                495
Val Glu Leu Glu Lys Asp Ser Glu Gly Leu Gly Ile Ser Ile Ile Gly 
             500                505                510
Met Gly Ala Gly Ala Asp Met Gly Leu Glu Lys Leu Gly Ile Phe Val 
         515                520                525
Lys Thr Val Thr Glu Gly Gly Ala Ala His Arg Asp Gly Arg Ile Gln 
     530                535                540
Val Asn Asp Leu Leu Val Glu Val Asp Gly Thr Ser Leu Val Gly Val 
 545                550                555                560
Thr Gln Ser Phe Ala Ala Ser Val Leu Arg Asn Thr Lys Gly Arg Val 
                 565                570                575
Arg Phe Met Ile Gly Arg Glu Arg Pro Gly Glu Gln Ser Glu Val Ala 
             580                585                590
Gln Leu Ile Gln Gln Thr Leu Glu Gln Glu Arg Trp Gln Arg Glu Met 
         595                600                605
Met Glu Gln Arg Tyr Ala Gln Tyr Gly Glu Asp Asp Glu Glu Thr Gly 
     610                615                620
Glu Tyr Ala Thr Asp Glu Asp Glu Glu Leu Ser Pro Thr Phe Pro Gly 
 625                630                635                640
Gly Glu Met Ala Ile Glu Val Phe Glu Leu Ala Glu Asn Glu Asp Ala 
                 645                650                655
Leu Ser Pro Val Glu Met Glu Pro Glu Lys Leu Val His Lys Phe Lys 
             660                665                670
Glu Leu Gln Ile Lys His Ala Val Thr Glu Ala Glu Ile Gln Gln Leu 
         675                680                685
Lys Arg Lys Leu Gln Ser Leu Glu Gln Glu Lys Gly Arg Trp Arg Val 
     690                695                700
Glu Lys Ala Gln Leu Glu Gln Ser Val Glu Glu Asn Lys Glu Arg Met 
 705                710                715                720
Glu Lys Leu Glu Gly Tyr Trp Gly Glu Ala Gln Ser Leu Cys Gln Ala 
                 725                730                735
Val Asp Glu His Leu Arg Glu Thr Gln Ala Gln Tyr Gln Ala Leu Glu 
             740                745                750
Arg Lys Tyr Ser Lys Ala Lys Arg Leu Ile Lys Asp Tyr Gln Gln Lys 
         755                760                765
Glu Ile Glu Phe Leu Lys Lys Glu Thr Ala Gln Arg Arg Val Leu Glu 
     770                775                780
Glu Ser Glu Leu Ala Arg Lys Glu Glu Met Asp Lys Leu Leu Asp Lys 
 785                790                795                800
Ile Ser Glu Leu Glu Gly Asn Leu Gln Thr Leu Arg Asn Ser Asn Ser 
                 805                810                815
Thr 
             820



<210> 510
<211> 2559
<212> DNA
<213> Homo sapiens
<308> BC016162
<400> 510

gagggcctg  gcatcagca  catcggcat  ggcgccggg  cagacatgg  cctggagaa  60
ctgggtatc  tcgtcaaga  cgtgacgga  ggtggtgcg  cccatcggg  tggcaggat  120
caggtgaat  atctcctgg  ggaggtgga  ggaacaagt  tggtgggag  gacccagag  180
ttcgcggcg  ctgtgctcc  gaacaccaa  ggccgagtg  ggtttatga  tggccggga  240
cggccggga  agcagagcg  agtggccca  ctaattcag  agactttgg  acaggagcg  300
tggcagcgg  agatgatgg  gcagagata  gcccagtat  gggaggatg  cgaggagac  360
ggagagtat  ccactgacg  ggatgagga  ctgagcccc  cgttcccgg  tggtgagat  420
gccatcgag  tgtttgagc  agcggagaa  gaggatgca  tgtcccctg  ggacatgga  480
cccgagaag  tggtgcaca  gttcaagga  ctccagatc  agcatgcgg  cactgaggc  540
gagatccag  agctgaaaa  aaagctgca  agcctggag  aggagaagg  gcgctggcg  600
gtggagaag  cgcagttgg  gcagagtgt  gaggagaac  aggagcgca  ggagaaact  660
gaaggctac  ggggtgagg  ccagagcct  tgccaggct  tggacgagc  cctgcggga  720
actcaggcg  agtaccagg  cctggagcg  aagtacagc  aggccaagc  cctcatcaa  780
gactaccag  agaaggaga  cgagttcct  aaaaaggag  ctgcacagc  tcgggttct  840
gaggagtcg  agctggcca  aaaggagga  atggacaag  tcctggaca  gatctcaga  900
ctggaagga  acttgcaaa  actgaggaa  tccaattct  cttaacagg  atcattcca  960
gactggaca  taattaacc  ccctcccat  gtcctccct  ccctgtcct  aacacccca  1020
ccctccccc  tccagcctg  ggacaggtg  cccgactcc  cccacccct  caccccacc  1080
cccccagct  cagggacca  agggctcat  tcacaggcc  ccttaagat  gcctgggca  1140
acagaggtg  ctagaaggg  agcctcttt  ttgccccat  gggctgagg  acagaggcc  1200
agggctgcc  agggctggc  tggtggtcg  cggacacaa  cacctgcag  tcaaactgc  1260
agactttac  cactccagc  tttgtctct  gactggaac  gggctgggg  tctcccagc  1320
tctgccaac  gggggctgc  ccctgccca  ggggcacct  ggtggcccc  gggcctctt  1380
acttgagat  ctaccttct  ggcccttcc  tctcccccc  tcattgtgc  gtctctgtt  1440
cattctgac  ctcccgcct  gggggtggg  gcgttgcct  aacacctcc  ccatccctg  1500
tccctgtcc  gggagggat  gagtccacc  cagagcccg  aggctgggc  tggccctgg  1560
cctgcactg  tttctcatg  gtccttcgg  aaaaggggg  gtgagagtg  gaaaaaggg  1620
gagttcagg  cacctggtc  ccagctccc  attgcctgg  gcagcagcc  tcaatttct  1680
cttgtgcct  ccctcttcc  ggtgccaaa  agccataac  tcgtcttgg  actgttatg  1740
ggcctctct  gggtccagg  ttcctggtc  agcctggga  tgccaggga  gaaaggggg  1800
ctggctaca  cgaccctgg  cttaggcaa  gggaacatt  ctccctgga  agtcaggtc  1860
tatcctgtg  tgccctgtc  gcccagccc  gggcgatgc  tggaagcct  ctgacattg  1920
agggagtca  cctcgcccc  accccctac  ggttttcca  tgttttgac  ggagggcaa  1980
attttacta  tactcatct  tttggagac  agggctgcc  tgctggcag  ctgccttct  2040
agtgaaatc  actctgttt  cccacttta  ccccaaatt  gggcttgga  caagggagg  2100
gagaccccc  cccccaggt  ccctcccct  tcaaaatcc  tctcatttt  ccacttcat  2160
cccctgccc  aactgggtt  ttgttcatt  tttaaaaac  gaccaccca  cccatccgt  2220
ttggcttct  gtcccctgt  aatagacca  gacttcgat  agtatttct  gtccccacc  2280
cttcctatc  ccagatgtg  ccccatccc  tgaaggagc  ggctgtctc  gtcctgggc  2340
cgcgcactt  accccggca  atggagggg  cggaaccgg  tgggcgggg  cgcttcggg  2400
tgcttgggc  agcggccac  cctgcccag  cgtcgggag  gccgcatct  tgtatataa  2460
atatatatg  atgtattgt  cccggtttt  tacggacca  gccctctgt  aggtcgtcc  2520
cataaaagc  gcccccaga  caaaaaaaa  aaaaaaaaa  2559



<210> 511
<211> 817
<212> PRT
<213> Homo sapiens
<308> NP_115984
<400> 511

Met Met Lys Thr Glu Pro Arg Gly Pro Gly Gly Pro Leu Arg Ser Ala 
  1               5                  10                  15
Ser Pro His Arg Ser Ala Tyr Glu Ala Gly Ile Gln Ala Leu Lys Pro 
             20                  25                  30
Pro Asp Ala Pro Gly Pro Asp Glu Ala Pro Lys Gly Ala His His Lys 
         35                  40                  45
Lys Tyr Gly Ser Asn Val His Arg Ile Lys Ser Met Phe Leu Gln Met 
     50                  55                  60
Gly Thr Thr Ala Gly Pro Ser Gly Glu Ala Gly Gly Gly Ala Gly Leu 
 65                  70                  75                  80
Ala Glu Ala Pro Arg Ala Ser Glu Arg Gly Val Arg Leu Ser Leu Pro 
                 85                  90                  95
Arg Ala Ser Ser Leu Asn Glu Asn Val Asp His Ser Ala Leu Leu Lys 
             100                105                110
Leu Gly Thr Ser Val Ser Glu Arg Val Ser Arg Phe Asp Ser Lys Pro 
         115                120                125
Ala Pro Ser Ala Gln Pro Ala Pro Pro Pro His Pro Pro Ser Arg Leu 
     130                135                140
Gln Glu Thr Arg Lys Leu Phe Glu Arg Ser Ala Pro Ala Ala Gly Gly 
 145                150                155                160
Asp Lys Glu Ala Ala Arg Arg Leu Leu Arg Gln Glu Arg Ala Gly Leu 
                 165                170                175
Gln Asp Arg Lys Leu Asp Val Val Val Arg Phe Asn Gly Ser Thr Glu 
             180                185                190
Ala Leu Asp Lys Leu Asp Ala Asp Ala Val Ser Pro Thr Val Ser Gln 
         195                200                205
Leu Ser Ala Val Phe Glu Lys Ala Asp Ser Arg Thr Gly Leu His Arg 
     210                215                220
Gly Pro Gly Leu Pro Arg Ala Ala Gly Val Pro Gln Val Asn Ser Lys 
 225                230                235                240
Leu Val Ser Lys Arg Ser Arg Val Phe Gln Pro Pro Pro Pro Pro Pro 
                 245                250                255
Pro Ala Pro Ser Gly Asp Ala Pro Ala Glu Lys Glu Arg Cys Pro Ala 
             260                265                270
Gly Gln Gln Pro Pro Gln His Arg Val Ala Pro Ala Arg Pro Pro Pro 
         275                280                285
Lys Pro Arg Glu Val Arg Lys Ile Lys Pro Val Glu Val Glu Glu Ser 
     290                295                300
Gly Glu Ser Glu Ala Glu Ser Ala Pro Gly Glu Val Ile Gln Ala Glu 
 305                310                315                320
Val Thr Val His Ala Ala Leu Glu Asn Gly Ser Thr Val Ala Thr Ala 
                 325                330                335
Ala Ser Pro Ala Pro Glu Glu Pro Lys Ala Gln Ala Ala Pro Glu Lys 
             340                345                350
Glu Ala Ala Ala Val Ala Pro Pro Glu Arg Gly Val Gly Asn Gly Arg 
         355                360                365
Ala Pro Asp Val Ala Pro Glu Glu Val Asp Glu Ser Lys Lys Glu Asp 
     370                375                380
Phe Ser Glu Ala Asp Leu Val Asp Val Ser Ala Tyr Ser Gly Leu Gly 
 385                390                395                400
Glu Asp Ser Ala Gly Ser Ala Leu Glu Glu Asp Asp Glu Asp Asp Glu 
                 405                410                415
Glu Asp Gly Glu Pro Pro Tyr Glu Pro Glu Ser Gly Cys Val Glu Ile 
             420                425                430
Pro Gly Leu Ser Glu Glu Glu Asp Pro Ala Pro Ser Arg Lys Ile His 
         435                440                445
Phe Ser Thr Ala Pro Ile Gln Val Phe Ser Thr Tyr Ser Asn Glu Asp 
     450                455                460
Tyr Asp Arg Arg Asn Glu Asp Val Asp Pro Met Ala Ala Ser Ala Glu 
 465                470                475                480
Tyr Glu Leu Glu Lys Arg Val Glu Arg Leu Glu Leu Phe Pro Val Glu 
                 485                490                495
Leu Glu Lys Asp Ser Glu Gly Leu Gly Ile Ser Ile Ile Gly Met Gly 
             500                505                510
Ala Gly Ala Asp Met Gly Leu Glu Lys Leu Gly Ile Phe Val Lys Thr 
         515                520                525
Val Thr Glu Gly Gly Ala Ala His Arg Asp Gly Arg Ile Gln Val Asn 
     530                535                540
Asp Leu Leu Val Glu Val Asp Gly Thr Ser Leu Val Gly Val Thr Gln 
 545                550                555                560
Ser Phe Ala Ala Ser Val Leu Arg Asn Thr Lys Gly Arg Val Arg Cys 
                 565                570                575
Arg Phe Met Ile Gly Arg Glu Arg Pro Gly Glu Gln Ser Glu Val Ala 
             580                585                590
Gln Leu Ile Gln Gln Thr Leu Glu Gln Glu Arg Trp Gln Arg Glu Met 
         595                600                605
Met Glu Gln Arg Tyr Ala Gln Tyr Gly Glu Asp Asp Glu Glu Thr Gly 
     610                615                620
Glu Tyr Ala Thr Asp Glu Asp Glu Glu Leu Ser Pro Thr Phe Pro Gly 
 625                630                635                640
Gly Glu Met Ala Ile Glu Val Phe Glu Leu Ala Glu Asn Glu Asp Ala 
                 645                650                655
Leu Ser Pro Val Asp Met Glu Pro Glu Lys Leu Val His Lys Phe Lys 
             660                665                670
Glu Leu Gln Ile Lys His Ala Val Thr Glu Ala Glu Ile Gln Gln Leu 
         675                680                685
Lys Arg Lys Leu Gln Ser Leu Glu Gln Glu Lys Gly Arg Trp Arg Val 
     690                695                700
Glu Lys Ala Gln Leu Glu Gln Ser Val Glu Glu Asn Lys Glu Arg Met 
 705                710                715                720
Glu Lys Leu Glu Gly Tyr Trp Gly Glu Ala Gln Ser Leu Cys Gln Ala 
                 725                730                735
Val Asp Glu His Leu Arg Glu Thr Gln Ala Gln Tyr Gln Ala Leu Glu 
             740                745                750
Arg Lys Tyr Ser Lys Ala Lys Arg Leu Ile Lys Asp Tyr Gln Gln Lys 
         755                760                765
Glu Ile Glu Phe Leu Lys Lys Glu Thr Ala Gln Arg Arg Val Leu Glu 
     770                775                780
Glu Ser Glu Leu Ala Arg Lys Glu Glu Met Asp Lys Leu Leu Asp Lys 
 785                790                795                800
Ile Ser Glu Leu Glu Gly Asn Leu Gln Thr Leu Arg Asn Ser Asn Ser 
                 805                810                815
Thr 
             820



<210> 512
<211> 669
<212> DNA
<213> Rattus norvegicus
<308> AF016387
<400> 512

ccaagatga  ggacatgcg  atggataag  cggagctcg  gtgcctgcg  gccattgtg  60
tgttcaatc  agatgccaa  ggtttgtcc  acccctcgg  ggtggagtc  cttcgagag  120
aggtttatg  caccctcga  ccctatacc  agcagaagt  tccggaaca  cctggcagg  180
ttgccaagc  tctgctgcg  ctcccagct  tgcgctcca  tggattgaa  tgcctggaa  240
acctcttct  cttcaagct  attggggat  cccccattg  caccttcct  atggagatg  300
tggagaccc  tctgcagat  acctgaaac  cctcggcag  agcttcctc  cccagagtg  360
cccctgggc  ggtgtgtgt  tcgccctac  cctgcacac  gtcctctcc  actctgact  420
cccttcctg  ccccaaaat  tgatgcttg  cccgaataa  tacaacctt  ctacacatg  480
gacttttct  ggtggagtt  tgtatggtt  ttaaaggtg  cccttcttt  ctacttaag  540
ggctgagtc  ggcagttct  ggaagagta  ccaagcctc  gtacatata  ttatcttgg  600
ttaaattat  ttttcactt  ccatggaaa  caaacaaat  gaaaagaaa  taataaata  660
gatactggc  669



<210> 513
<211> 107
<212> PRT
<213> Rattus norvegicus
<308> AAD01591
<400> 513

Lys Met Lys Asp Met Arg Met Asp Lys Ser Glu Leu Gly Cys Leu Arg 
  1               5                  10                  15
Ala Ile Val Leu Phe Asn Pro Asp Ala Lys Gly Leu Ser Asn Pro Ser 
             20                  25                  30
Glu Val Glu Ser Leu Arg Glu Lys Val Tyr Ala Thr Leu Glu Pro Tyr 
         35                  40                  45
Thr Lys Gln Lys Tyr Pro Glu Gln Pro Gly Arg Phe Ala Lys Leu Leu 
     50                  55                  60
Leu Arg Leu Pro Ala Leu Arg Ser Ile Gly Leu Lys Cys Leu Glu His 
 65                  70                  75                  80
Leu Phe Phe Phe Lys Leu Ile Gly Asp Thr Pro Ile Asp Thr Phe Leu 
                 85                  90                  95
Met Glu Met Leu Glu Thr Pro Leu Gln Ile Thr 
             100                105



<210> 514
<211> 1742
<212> DNA
<213> Homo sapiens
<308> NM_006917
<400> 514

ctccgatct  gaggcagat  cctgactaa  cccagaggg  tggcccagc  tgtgctccc  60
gggctgcta  gaagcgatg  ccactcttg  tagcccaag  tgaagaaag  cgggctgtg  120
ctgggagcc  agagaggcg  taatattta  aagctgcac  ggagaggaa  atgaactga  180
gagtaaaca  gtatggaaa  tattctcac  tcatgaagt  tcccgcagg  tatggaggc  240
cccctggcc  cactggctc  acatccatg  gcccatcag  agccttgtc  acagggaag  300
caatggaca  ccaccccag  tacacagat  ccccagtga  tgccccacg  actctgagt  360
cagtgggga  ccccctcaa  gccctgggc  ctccatatc  agtcatcac  tctgccatg  420
gcccaccct  aggagcact  gcagcgcct  caggaatca  cttggttgc  ccacccagc  480
ctcagctaa  tgtggtcaa  agtgtcagc  gttcagagg  catcaagcc  ttaccaggg  540
ttcccggga  tggaaacat  aactaccca  ccaccagcc  cggatctct  gttaaacac  600
tctgtgcca  ctgtggaga  agatcctca  gaaagcact  cggggtata  agttgtgaa  660
gctgcaaag  gttcttcaa  aggacgata  ggaaggacc  catctacac  tgtcgggat  720
ataaagact  cctcattga  aagcgtcag  gcaaccgct  ccagtactg  cgctatcag  780
agtgccttg  catgggcat  aagagggaa  ctgtgcaag  agaaagaca  aggagccga  840
agcgagctg  gagtgaggc  gaatgtgct  ccagtggtc  tgaagacat  cctgtggag  900
ggattctag  agctgaact  gctgttgaa  caaagacag  atcctatgg  gacatgaat  960
tggagaact  gacaaatga  cctgttacc  acatatgtc  tgctgctga  aagcagctt  1020
tcaccctcg  tgaatgggc  aagcgtatt  cccacttct  tgacctcac  ttggaggac  1080
aggtcattt  gcttcgggc  gggtggaat  aattgctga  tgcctcttt  tcccaccgc  1140
cagtttccg  gcaggatgg  atccttctg  ccacgggtt  acatgtcca  cggagcagt  1200
cccacagtg  tggggtcgg  tccatcttt  acagagtcc  aactgagct  gtttccaaa  1260
tgaaagaca  gcagatgga  aagtcggaa  tgggatgcc  gcgagccat  gtactcttt  1320
acccagatg  caagggcct  tccaacccc  ctgaggtgg  gactctgcg  gagaaggtt  1380
atgccaccc  tgaggccta  accaagcag  agtatccgg  acagccagg  aggtttgcc  1440
agctgctgc  gcgcctccc  gctctgcgt  ccattggct  gaaatgcct  gagcacctc  1500
tcttcttca  gctcatcgg  gacaccccc  ttgacacct  cctcatgga  atgttggag  1560
ccccgctgc  gatcacctg  gccccacca  ccacagcct  cccacccag  atgacccct  1620
ggcaggtgt  tgtggaccc  caccctgca  tttcctcca  ctcccaccc  gaccccctt  1680
ctgtcccca  aatgtgatg  ttataataa  gaaaacctt  ctacaaaaa  aaaaaaaaa  1740
aa  1742



<210> 515
<211> 463
<212> PRT
<213> Homo sapiens
<308> P48443
<400> 515

Met Tyr Gly Asn Tyr Ser His Phe Met Lys Phe Pro Ala Gly Tyr Gly 
  1               5                  10                  15
Gly Ser Pro Gly His Thr Gly Ser Thr Ser Met Ser Pro Ser Ala Ala 
             20                  25                  30
Leu Ser Thr Gly Lys Pro Met Asp Ser His Pro Ser Tyr Thr Asp Thr 
         35                  40                  45
Pro Val Ser Ala Pro Arg Thr Leu Ser Ala Val Gly Thr Pro Leu Asn 
     50                  55                  60
Ala Leu Gly Ser Pro Tyr Arg Val Ile Thr Ser Ala Met Gly Pro Pro 
 65                  70                  75                  80
Ser Gly Ala Leu Ala Ala Pro Pro Gly Ile Asn Leu Val Ala Pro Pro 
                 85                  90                  95
Ser Ser Gln Leu Asn Val Val Asn Ser Val Ser Ser Ser Glu Asp Ile 
             100                105                110
Lys Pro Leu Pro Gly Leu Pro Gly Ile Gly Asn Met Asn Tyr Pro Ser 
         115                120                125
Thr Ser Pro Gly Ser Leu Val Lys His Ile Cys Ala Ile Cys Gly Asp 
     130                135                140
Arg Ser Ser Gly Lys His Tyr Gly Val Tyr Ser Cys Glu Gly Cys Lys 
 145                150                155                160
Gly Phe Phe Lys Arg Thr Ile Arg Lys Asp Leu Ile Tyr Thr Cys Arg 
                 165                170                175
Asp Asn Lys Asp Cys Leu Ile Asp Lys Arg Gln Arg Asn Arg Cys Gln 
             180                185                190
Tyr Cys Arg Tyr Gln Lys Cys Leu Val Met Gly Met Lys Arg Glu Ala 
         195                200                205
Val Gln Glu Glu Arg Gln Arg Ser Arg Glu Arg Ala Glu Ser Glu Ala 
     210                215                220
Glu Cys Ala Thr Ser Gly His Glu Asp Met Pro Val Glu Arg Ile Leu 
 225                230                235                240
Glu Ala Glu Leu Ala Val Glu Pro Lys Thr Glu Ser Tyr Gly Asp Met 
                 245                250                255
Asn Met Glu Asn Ser Thr Asn Asp Pro Val Thr Asn Ile Cys His Ala 
             260                265                270
Ala Asp Lys Gln Leu Phe Thr Leu Val Glu Trp Ala Lys Arg Ile Pro 
         275                280                285
His Phe Ser Asp Leu Thr Leu Glu Asp Gln Val Ile Leu Leu Arg Ala 
     290                295                300
Gly Trp Asn Glu Leu Leu Ile Ala Ser Phe Ser His Arg Ser Val Ser 
 305                310                315                320
Val Gln Asp Gly Ile Leu Leu Ala Thr Gly Leu His Val His Arg Ser 
                 325                330                335
Ser Ala His Ser Ala Gly Val Gly Ser Ile Phe Asp Arg Val Leu Thr 
             340                345                350
Glu Leu Val Ser Lys Met Lys Asp Met Gln Met Asp Lys Ser Glu Leu 
         355                360                365
Gly Cys Leu Arg Ala Ile Val Leu Phe Asn Pro Asp Ala Lys Gly Leu 
     370                375                380
Ser Asn Pro Ser Glu Val Glu Thr Leu Arg Glu Lys Val Tyr Ala Thr 
 385                390                395                400
Leu Glu Ala Tyr Thr Lys Gln Lys Tyr Pro Glu Gln Pro Gly Arg Phe 
                 405                410                415
Ala Lys Leu Leu Leu Arg Leu Pro Ala Leu Arg Ser Ile Gly Leu Lys 
             420                425                430
Cys Leu Glu His Leu Phe Phe Phe Lys Leu Ile Gly Asp Thr Pro Ile 
         435                440                445
Asp Thr Phe Leu Met Glu Met Leu Glu Thr Pro Leu Gln Ile Thr 
     450                455                460



<210> 516
<211> 669
<212> DNA
<213> Rattus norvegicus
<308> AF016387
<400> 516

ccaagatga  ggacatgcg  atggataag  cggagctcg  gtgcctgcg  gccattgtg  60
tgttcaatc  agatgccaa  ggtttgtcc  acccctcgg  ggtggagtc  cttcgagag  120
aggtttatg  caccctcga  ccctatacc  agcagaagt  tccggaaca  cctggcagg  180
ttgccaagc  tctgctgcg  ctcccagct  tgcgctcca  tggattgaa  tgcctggaa  240
acctcttct  cttcaagct  attggggat  cccccattg  caccttcct  atggagatg  300
tggagaccc  tctgcagat  acctgaaac  cctcggcag  agcttcctc  cccagagtg  360
cccctgggc  ggtgtgtgt  tcgccctac  cctgcacac  gtcctctcc  actctgact  420
cccttcctg  ccccaaaat  tgatgcttg  cccgaataa  tacaacctt  ctacacatg  480
gacttttct  ggtggagtt  tgtatggtt  ttaaaggtg  cccttcttt  ctacttaag  540
ggctgagtc  ggcagttct  ggaagagta  ccaagcctc  gtacatata  ttatcttgg  600
ttaaattat  ttttcactt  ccatggaaa  caaacaaat  gaaaagaaa  taataaata  660
gatactggc  669



<210> 517
<211> 107
<212> PRT
<213> Rattus norvegicus
<308> AAD01591
<400> 517

Lys Met Lys Asp Met Arg Met Asp Lys Ser Glu Leu Gly Cys Leu Arg 
  1               5                  10                  15
Ala Ile Val Leu Phe Asn Pro Asp Ala Lys Gly Leu Ser Asn Pro Ser 
             20                  25                  30
Glu Val Glu Ser Leu Arg Glu Lys Val Tyr Ala Thr Leu Glu Pro Tyr 
         35                  40                  45
Thr Lys Gln Lys Tyr Pro Glu Gln Pro Gly Arg Phe Ala Lys Leu Leu 
     50                  55                  60
Leu Arg Leu Pro Ala Leu Arg Ser Ile Gly Leu Lys Cys Leu Glu His 
 65                  70                  75                  80
Leu Phe Phe Phe Lys Leu Ile Gly Asp Thr Pro Ile Asp Thr Phe Leu 
                 85                  90                  95
Met Glu Met Leu Glu Thr Pro Leu Gln Ile Thr 
             100                105



<210> 518
<211> 1742
<212> DNA
<213> Homo sapiens
<308> NM_006917
<400> 518

ctccgatct  gaggcagat  cctgactaa  cccagaggg  tggcccagc  tgtgctccc  60
gggctgcta  gaagcgatg  ccactcttg  tagcccaag  tgaagaaag  cgggctgtg  120
ctgggagcc  agagaggcg  taatattta  aagctgcac  ggagaggaa  atgaactga  180
gagtaaaca  gtatggaaa  tattctcac  tcatgaagt  tcccgcagg  tatggaggc  240
cccctggcc  cactggctc  acatccatg  gcccatcag  agccttgtc  acagggaag  300
caatggaca  ccaccccag  tacacagat  ccccagtga  tgccccacg  actctgagt  360
cagtgggga  ccccctcaa  gccctgggc  ctccatatc  agtcatcac  tctgccatg  420
gcccaccct  aggagcact  gcagcgcct  caggaatca  cttggttgc  ccacccagc  480
ctcagctaa  tgtggtcaa  agtgtcagc  gttcagagg  catcaagcc  ttaccaggg  540
ttcccggga  tggaaacat  aactaccca  ccaccagcc  cggatctct  gttaaacac  600
tctgtgcca  ctgtggaga  agatcctca  gaaagcact  cggggtata  agttgtgaa  660
gctgcaaag  gttcttcaa  aggacgata  ggaaggacc  catctacac  tgtcgggat  720
ataaagact  cctcattga  aagcgtcag  gcaaccgct  ccagtactg  cgctatcag  780
agtgccttg  catgggcat  aagagggaa  ctgtgcaag  agaaagaca  aggagccga  840
agcgagctg  gagtgaggc  gaatgtgct  ccagtggtc  tgaagacat  cctgtggag  900
ggattctag  agctgaact  gctgttgaa  caaagacag  atcctatgg  gacatgaat  960
tggagaact  gacaaatga  cctgttacc  acatatgtc  tgctgctga  aagcagctt  1020
tcaccctcg  tgaatgggc  aagcgtatt  cccacttct  tgacctcac  ttggaggac  1080
aggtcattt  gcttcgggc  gggtggaat  aattgctga  tgcctcttt  tcccaccgc  1140
cagtttccg  gcaggatgg  atccttctg  ccacgggtt  acatgtcca  cggagcagt  1200
cccacagtg  tggggtcgg  tccatcttt  acagagtcc  aactgagct  gtttccaaa  1260
tgaaagaca  gcagatgga  aagtcggaa  tgggatgcc  gcgagccat  gtactcttt  1320
acccagatg  caagggcct  tccaacccc  ctgaggtgg  gactctgcg  gagaaggtt  1380
atgccaccc  tgaggccta  accaagcag  agtatccgg  acagccagg  aggtttgcc  1440
agctgctgc  gcgcctccc  gctctgcgt  ccattggct  gaaatgcct  gagcacctc  1500
tcttcttca  gctcatcgg  gacaccccc  ttgacacct  cctcatgga  atgttggag  1560
ccccgctgc  gatcacctg  gccccacca  ccacagcct  cccacccag  atgacccct  1620
ggcaggtgt  tgtggaccc  caccctgca  tttcctcca  ctcccaccc  gaccccctt  1680
ctgtcccca  aatgtgatg  ttataataa  gaaaacctt  ctacaaaaa  aaaaaaaaa  1740
aa  1742



<210> 519
<211> 463
<212> PRT
<213> Homo sapiens
<308> P48443
<400> 519

Met Tyr Gly Asn Tyr Ser His Phe Met Lys Phe Pro Ala Gly Tyr Gly 
  1               5                  10                  15
Gly Ser Pro Gly His Thr Gly Ser Thr Ser Met Ser Pro Ser Ala Ala 
             20                  25                  30
Leu Ser Thr Gly Lys Pro Met Asp Ser His Pro Ser Tyr Thr Asp Thr 
         35                  40                  45
Pro Val Ser Ala Pro Arg Thr Leu Ser Ala Val Gly Thr Pro Leu Asn 
     50                  55                  60
Ala Leu Gly Ser Pro Tyr Arg Val Ile Thr Ser Ala Met Gly Pro Pro 
 65                  70                  75                  80
Ser Gly Ala Leu Ala Ala Pro Pro Gly Ile Asn Leu Val Ala Pro Pro 
                 85                  90                  95
Ser Ser Gln Leu Asn Val Val Asn Ser Val Ser Ser Ser Glu Asp Ile 
             100                105                110
Lys Pro Leu Pro Gly Leu Pro Gly Ile Gly Asn Met Asn Tyr Pro Ser 
         115                120                125
Thr Ser Pro Gly Ser Leu Val Lys His Ile Cys Ala Ile Cys Gly Asp 
     130                135                140
Arg Ser Ser Gly Lys His Tyr Gly Val Tyr Ser Cys Glu Gly Cys Lys 
 145                150                155                160
Gly Phe Phe Lys Arg Thr Ile Arg Lys Asp Leu Ile Tyr Thr Cys Arg 
                 165                170                175
Asp Asn Lys Asp Cys Leu Ile Asp Lys Arg Gln Arg Asn Arg Cys Gln 
             180                185                190
Tyr Cys Arg Tyr Gln Lys Cys Leu Val Met Gly Met Lys Arg Glu Ala 
         195                200                205
Val Gln Glu Glu Arg Gln Arg Ser Arg Glu Arg Ala Glu Ser Glu Ala 
     210                215                220
Glu Cys Ala Thr Ser Gly His Glu Asp Met Pro Val Glu Arg Ile Leu 
 225                230                235                240
Glu Ala Glu Leu Ala Val Glu Pro Lys Thr Glu Ser Tyr Gly Asp Met 
                 245                250                255
Asn Met Glu Asn Ser Thr Asn Asp Pro Val Thr Asn Ile Cys His Ala 
             260                265                270
Ala Asp Lys Gln Leu Phe Thr Leu Val Glu Trp Ala Lys Arg Ile Pro 
         275                280                285
His Phe Ser Asp Leu Thr Leu Glu Asp Gln Val Ile Leu Leu Arg Ala 
     290                295                300
Gly Trp Asn Glu Leu Leu Ile Ala Ser Phe Ser His Arg Ser Val Ser 
 305                310                315                320
Val Gln Asp Gly Ile Leu Leu Ala Thr Gly Leu His Val His Arg Ser 
                 325                330                335
Ser Ala His Ser Ala Gly Val Gly Ser Ile Phe Asp Arg Val Leu Thr 
             340                345                350
Glu Leu Val Ser Lys Met Lys Asp Met Gln Met Asp Lys Ser Glu Leu 
         355                360                365
Gly Cys Leu Arg Ala Ile Val Leu Phe Asn Pro Asp Ala Lys Gly Leu 
     370                375                380
Ser Asn Pro Ser Glu Val Glu Thr Leu Arg Glu Lys Val Tyr Ala Thr 
 385                390                395                400
Leu Glu Ala Tyr Thr Lys Gln Lys Tyr Pro Glu Gln Pro Gly Arg Phe 
                 405                410                415
Ala Lys Leu Leu Leu Arg Leu Pro Ala Leu Arg Ser Ile Gly Leu Lys 
             420                425                430
Cys Leu Glu His Leu Phe Phe Phe Lys Leu Ile Gly Asp Thr Pro Ile 
         435                440                445
Asp Thr Phe Leu Met Glu Met Leu Glu Thr Pro Leu Gln Ile Thr 
     450                455                460



<210> 520
<211> 1283
<212> DNA
<213> Rattus norvegicus
<308> AF017437
<400> 520

cggcgcgga  atgtggccc  tggcggcgg  gcgctcctg  tgctgcggt  cagctcaac  60
cctgcttag  aaagtcaaa  ctgtagagt  cacgtcatg  aatgacact  tggtcatcc  120
ttgcaaagt  cttaatgtg  aggcccaaa  caccgatga  atgtttgtg  agtggaagt  180
gaacaaatc  tatattttc  tctatgatg  aaataaaaa  agcactact  gagaacaaa  240
ctttaccag  gcaaaaatc  cggtctcag  cttgctcaa  ggcattgcc  ctttgacaa  300
ggataccca  gaggctgtg  tgggaaact  cacctgtga  gtgactgag  tttccagag  360
aggcaaaac  gttatagag  tgaaaaacc  cccagtttc  tggttttct  caaatgaaa  420
gatcctcat  gttattttc  caattttgg  tatactcct  ttctgggga  agtttggta  480
attaacact  aaatacaag  ccagccata  gaataagag  atcattctg  tgctggttg  540
cgggctggc  ctcacactc  tcgtggttg  tggcgccat  cttttcatc  cgggagaga  600
gcccgtgaa  aacgcttct  gtcttggcc  cattgtaat  tccacagga  tattaatac  660
gcttcagta  aatgtgttt  tgacagctt  tggaatgac  tctttcacc  ttgccatat  720
gatcactca  gtgctgggc  atgtccttg  tgtggtcgg  atgtgtctt  gcatcatgg  780
ttgtgaacc  gtgcacggc  cccttttga  ttcaggttt  ggaatcata  ctttagcag  840
attacttgg  ctagtttat  tgaagtttg  cgcttccaa  cagcgaact  tacaacctc  900
taggaaagc  gtagaggaa  cccttaacg  gtttaaaga  tcgaaaggg  tgatgaatg  960
cgaataact  aagggaagt  acggactgt  acttgaaag  cagaagtgg  agaattcag  1020
tgtctgagc  ccatggcct  cacaactca  agctggaag  aacacacaa  agtgactga  1080
tttcatctc  gaaaaaagt  attgaacca  aaatgaata  tacagttaa  tttatatta  1140
agcagctgt  atttacgta  taaaaaata  atgatgtgc  gtgaaaaaa  aaaaaaaaa  1200
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1260
aaaaaaaaa  aaaaaaaaa  aaa  1283



<210> 521
<211> 318
<212> PRT
<213> Rattus norvegicus
<308> AAB70273
<400> 521

Met Trp Pro Leu Ala Ala Ala Arg Ser Cys Cys Cys Gly Ser Ala Gln 
  1               5                  10                  15
Leu Leu Leu Ser Lys Val Lys Ser Val Glu Phe Thr Ser Cys Asn Asp 
             20                  25                  30
Thr Val Val Ile Pro Cys Lys Val Leu Asn Val Glu Ala Gln Ser Thr 
         35                  40                  45
Asp Glu Met Phe Val Lys Trp Lys Leu Asn Lys Ser Tyr Ile Phe Ile 
     50                  55                  60
Tyr Asp Gly Asn Lys Asn Ser Thr Thr Arg Glu Gln Asn Phe Thr Ser 
 65                  70                  75                  80
Ala Lys Ile Ser Val Ser Asp Leu Leu Lys Gly Ile Ala Ser Leu Thr 
                 85                  90                  95
Met Asp Thr His Glu Ala Val Val Gly Asn Tyr Thr Cys Glu Val Thr 
             100                105                110
Glu Leu Ser Arg Glu Gly Lys Thr Val Ile Glu Leu Lys Asn Arg Pro 
         115                120                125
Val Ser Trp Phe Ser Thr Asn Glu Lys Ile Leu Ile Val Ile Phe Pro 
     130                135                140
Ile Leu Ala Ile Leu Leu Phe Trp Gly Lys Phe Gly Ile Leu Thr Leu 
 145                150                155                160
Lys Tyr Lys Ser Ser His Thr Asn Lys Arg Ile Ile Leu Leu Leu Val 
                 165                170                175
Ala Gly Leu Ala Leu Thr Leu Ile Val Val Val Gly Ala Ile Leu Phe 
             180                185                190
Ile Pro Gly Glu Lys Pro Val Lys Asn Ala Ser Gly Leu Gly Leu Ile 
         195                200                205
Val Ile Ser Thr Gly Ile Leu Ile Leu Leu Gln Tyr Asn Val Phe Met 
     210                215                220
Thr Ala Phe Gly Met Thr Ser Phe Thr Ile Ala Ile Leu Ile Thr Gln 
 225                230                235                240
Val Leu Gly Tyr Val Leu Ala Val Val Gly Met Cys Leu Cys Ile Met 
                 245                250                255
Ala Cys Glu Pro Val His Gly Pro Leu Leu Ile Ser Gly Leu Gly Ile 
             260                265                270
Ile Ala Leu Ala Glu Leu Leu Gly Leu Val Tyr Met Lys Phe Val Ala 
         275                280                285
Ser Asn Gln Arg Thr Ile Gln Pro Pro Arg Lys Ala Val Glu Glu Pro 
     290                295                300
Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met Asn Asp Glu 
 305                310                315



<210> 522
<211> 1285
<212> DNA
<213> Homo sapiens
<308> NM_001777
<400> 522

gggctgcct  tgacgcgcg  cgcggtcgg  cctgcctgt  acggcggcg  cggctgctg  60
tccagacac  tgcggcggc  gcggcgacc  cgcggcggg  gcggagatg  ggcccctgg  120
agcggcgct  ttgctgggc  cggcgtgct  cggatcagc  cagctacta  ttaataaaa  180
aaaatctgt  gaattcacg  tttgtaatg  cactgtcgt  attccatgc  ttgttacta  240
tatggaggc  caaaacact  ctgaagtat  cgtaaagtg  aaatttaaa  gaagagata  300
ttacacctt  gatggagct  taaacaagt  cactgtccc  actgacttt  gtagtgcaa  360
aattgaagt  tcacaatta  taaaaggag  tgcctcttt  aagatggat  agagtgatg  420
tgtctcaca  acaggaaac  acacttgtg  agtaacaga  ttaaccaga  aaggtgaaa  480
gatcatcga  ctaaaatat  gtgttgttt  atggttttc  ccaaatgaa  atattctta  540
tgttatttt  ccaattttt  ctatactcc  gttctgggg  cagtttggt  ttaaaacac  600
taaatatag  tccggtggt  tggatgaga  aacaattgc  ttacttgtt  ctggactag  660
gatcactgt  attgtcatt  ttggagcca  tcttttcgt  ccaggtgaa  attcattaa  720
gaatgctac  ggccttggt  taattgtga  ttctacagg  atattaata  tacttcact  780
ctatgtgtt  agtacagcg  ttggattaa  ctccttcgt  attgccata  tggttattc  840
ggtgatagc  tatatcctc  ctgtggttg  actgagtct  tgtattgcg  cgtgtatac  900
aatgcatgg  cctcttctg  tttcaggtt  gagtatctt  gctctagca  aattacttg  960
actagttta  atgaaattt  tggcttcca  tcagaagac  atacaacct  ctaggaaag  1020
tgtagagga  ccccttaat  cattcaaag  atcaaaagg  atgatgaat  atgaataac  1080
gaagtgaag  gatggactc  gatttggag  gtagtaaga  gtgaaagga  tacacttct  1140
tttaagcac  atggccttg  tgattcact  ttggggaga  gaaacaaga  aagtaactg  1200
ttgtcacct  tgagaccct  acgtgattg  tagttaagt  tttattcaa  gcagctgta  1260
tttagttaa  aaaataatt  tgatc  1285



<210> 523
<211> 323
<212> PRT
<213> Homo sapiens
<308> Q08722
<400> 523

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
  1               5                  10                  15
Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
             20                  25                  30
Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
         35                  40                  45
Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
     50                  55                  60
Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
 65                  70                  75                  80
Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                 85                  90                  95
Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
             100                105                110
Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
         115                120                125
Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
     130                135                140
Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
 145                150                155                160
Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                 165                170                175
Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
             180                185                190
Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
         195                200                205
Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
     210                215                220
Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
 225                230                235                240
Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                 245                250                255
Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
             260                265                270
Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
         275                280                285
Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
     290                295                300
Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
 305                310                315                320
Asn Asp Glu 
                 325



<210> 524
<211> 1283
<212> DNA
<213> Rattus norvegicus
<308> AF017437
<400> 524

cggcgcgga  atgtggccc  tggcggcgg  gcgctcctg  tgctgcggt  cagctcaac  60
cctgcttag  aaagtcaaa  ctgtagagt  cacgtcatg  aatgacact  tggtcatcc  120
ttgcaaagt  cttaatgtg  aggcccaaa  caccgatga  atgtttgtg  agtggaagt  180
gaacaaatc  tatattttc  tctatgatg  aaataaaaa  agcactact  gagaacaaa  240
ctttaccag  gcaaaaatc  cggtctcag  cttgctcaa  ggcattgcc  ctttgacaa  300
ggataccca  gaggctgtg  tgggaaact  cacctgtga  gtgactgag  tttccagag  360
aggcaaaac  gttatagag  tgaaaaacc  cccagtttc  tggttttct  caaatgaaa  420
gatcctcat  gttattttc  caattttgg  tatactcct  ttctgggga  agtttggta  480
attaacact  aaatacaag  ccagccata  gaataagag  atcattctg  tgctggttg  540
cgggctggc  ctcacactc  tcgtggttg  tggcgccat  cttttcatc  cgggagaga  600
gcccgtgaa  aacgcttct  gtcttggcc  cattgtaat  tccacagga  tattaatac  660
gcttcagta  aatgtgttt  tgacagctt  tggaatgac  tctttcacc  ttgccatat  720
gatcactca  gtgctgggc  atgtccttg  tgtggtcgg  atgtgtctt  gcatcatgg  780
ttgtgaacc  gtgcacggc  cccttttga  ttcaggttt  ggaatcata  ctttagcag  840
attacttgg  ctagtttat  tgaagtttg  cgcttccaa  cagcgaact  tacaacctc  900
taggaaagc  gtagaggaa  cccttaacg  gtttaaaga  tcgaaaggg  tgatgaatg  960
cgaataact  aagggaagt  acggactgt  acttgaaag  cagaagtgg  agaattcag  1020
tgtctgagc  ccatggcct  cacaactca  agctggaag  aacacacaa  agtgactga  1080
tttcatctc  gaaaaaagt  attgaacca  aaatgaata  tacagttaa  tttatatta  1140
agcagctgt  atttacgta  taaaaaata  atgatgtgc  gtgaaaaaa  aaaaaaaaa  1200
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1260
aaaaaaaaa  aaaaaaaaa  aaa  1283



<210> 525
<211> 318
<212> PRT
<213> Rattus norvegicus
<308> AAB70273
<400> 525

Met Trp Pro Leu Ala Ala Ala Arg Ser Cys Cys Cys Gly Ser Ala Gln 
  1               5                  10                  15
Leu Leu Leu Ser Lys Val Lys Ser Val Glu Phe Thr Ser Cys Asn Asp 
             20                  25                  30
Thr Val Val Ile Pro Cys Lys Val Leu Asn Val Glu Ala Gln Ser Thr 
         35                  40                  45
Asp Glu Met Phe Val Lys Trp Lys Leu Asn Lys Ser Tyr Ile Phe Ile 
     50                  55                  60
Tyr Asp Gly Asn Lys Asn Ser Thr Thr Arg Glu Gln Asn Phe Thr Ser 
 65                  70                  75                  80
Ala Lys Ile Ser Val Ser Asp Leu Leu Lys Gly Ile Ala Ser Leu Thr 
                 85                  90                  95
Met Asp Thr His Glu Ala Val Val Gly Asn Tyr Thr Cys Glu Val Thr 
             100                105                110
Glu Leu Ser Arg Glu Gly Lys Thr Val Ile Glu Leu Lys Asn Arg Pro 
         115                120                125
Val Ser Trp Phe Ser Thr Asn Glu Lys Ile Leu Ile Val Ile Phe Pro 
     130                135                140
Ile Leu Ala Ile Leu Leu Phe Trp Gly Lys Phe Gly Ile Leu Thr Leu 
 145                150                155                160
Lys Tyr Lys Ser Ser His Thr Asn Lys Arg Ile Ile Leu Leu Leu Val 
                 165                170                175
Ala Gly Leu Ala Leu Thr Leu Ile Val Val Val Gly Ala Ile Leu Phe 
             180                185                190
Ile Pro Gly Glu Lys Pro Val Lys Asn Ala Ser Gly Leu Gly Leu Ile 
         195                200                205
Val Ile Ser Thr Gly Ile Leu Ile Leu Leu Gln Tyr Asn Val Phe Met 
     210                215                220
Thr Ala Phe Gly Met Thr Ser Phe Thr Ile Ala Ile Leu Ile Thr Gln 
 225                230                235                240
Val Leu Gly Tyr Val Leu Ala Val Val Gly Met Cys Leu Cys Ile Met 
                 245                250                255
Ala Cys Glu Pro Val His Gly Pro Leu Leu Ile Ser Gly Leu Gly Ile 
             260                265                270
Ile Ala Leu Ala Glu Leu Leu Gly Leu Val Tyr Met Lys Phe Val Ala 
         275                280                285
Ser Asn Gln Arg Thr Ile Gln Pro Pro Arg Lys Ala Val Glu Glu Pro 
     290                295                300
Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met Asn Asp Glu 
 305                310                315



<210> 526
<211> 1285
<212> DNA
<213> Homo sapiens
<308> NM_001777
<400> 526

gggctgcct  tgacgcgcg  cgcggtcgg  cctgcctgt  acggcggcg  cggctgctg  60
tccagacac  tgcggcggc  gcggcgacc  cgcggcggg  gcggagatg  ggcccctgg  120
agcggcgct  ttgctgggc  cggcgtgct  cggatcagc  cagctacta  ttaataaaa  180
aaaatctgt  gaattcacg  tttgtaatg  cactgtcgt  attccatgc  ttgttacta  240
tatggaggc  caaaacact  ctgaagtat  cgtaaagtg  aaatttaaa  gaagagata  300
ttacacctt  gatggagct  taaacaagt  cactgtccc  actgacttt  gtagtgcaa  360
aattgaagt  tcacaatta  taaaaggag  tgcctcttt  aagatggat  agagtgatg  420
tgtctcaca  acaggaaac  acacttgtg  agtaacaga  ttaaccaga  aaggtgaaa  480
gatcatcga  ctaaaatat  gtgttgttt  atggttttc  ccaaatgaa  atattctta  540
tgttatttt  ccaattttt  ctatactcc  gttctgggg  cagtttggt  ttaaaacac  600
taaatatag  tccggtggt  tggatgaga  aacaattgc  ttacttgtt  ctggactag  660
gatcactgt  attgtcatt  ttggagcca  tcttttcgt  ccaggtgaa  attcattaa  720
gaatgctac  ggccttggt  taattgtga  ttctacagg  atattaata  tacttcact  780
ctatgtgtt  agtacagcg  ttggattaa  ctccttcgt  attgccata  tggttattc  840
ggtgatagc  tatatcctc  ctgtggttg  actgagtct  tgtattgcg  cgtgtatac  900
aatgcatgg  cctcttctg  tttcaggtt  gagtatctt  gctctagca  aattacttg  960
actagttta  atgaaattt  tggcttcca  tcagaagac  atacaacct  ctaggaaag  1020
tgtagagga  ccccttaat  cattcaaag  atcaaaagg  atgatgaat  atgaataac  1080
gaagtgaag  gatggactc  gatttggag  gtagtaaga  gtgaaagga  tacacttct  1140
tttaagcac  atggccttg  tgattcact  ttggggaga  gaaacaaga  aagtaactg  1200
ttgtcacct  tgagaccct  acgtgattg  tagttaagt  tttattcaa  gcagctgta  1260
tttagttaa  aaaataatt  tgatc  1285



<210> 527
<211> 323
<212> PRT
<213> Homo sapiens
<308> Q08722
<400> 527

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
  1               5                  10                  15
Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
             20                  25                  30
Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
         35                  40                  45
Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
     50                  55                  60
Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
 65                  70                  75                  80
Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                 85                  90                  95
Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
             100                105                110
Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
         115                120                125
Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
     130                135                140
Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
 145                150                155                160
Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                 165                170                175
Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
             180                185                190
Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
         195                200                205
Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
     210                215                220
Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
 225                230                235                240
Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                 245                250                255
Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
             260                265                270
Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
         275                280                285
Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
     290                295                300
Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
 305                310                315                320
Asn Asp Glu 
                 325



<210> 528
<211> 2047
<212> DNA
<213> Rattus norvegicus
<308> AF018261
<400> 528

gcacgaggg  tcatggtag  gctcagtaa  tctccctcc  tggcttgtt  gagaggcat  60
gactgttga  cggagtcta  tctggaccc  ggctgctcc  gttgtgaga  gtggtgatc  120
accagtgtc  attgcggtc  ccctttgtg  gtcgcgtca  ctctccatg  cccgggggg  180
tggtgcccc  tgacaccac  actgggcac  atgtcgaca  catcgctgc  gcgtcagat  240
aagaatatc  tccacaact  ctcagaggc  gagatcaag  tccgggagg  cacaagcaa  300
gatccctgg  gcccatcca  ctccctcat  tcagagatt  ctgacctca  ctacaatgt  360
gtggccttc  ccgagatta  gagcatgat  tggaagcgg  tcaacgacc  tggcaagaa  420
tggaggcac  tctacaagg  catgacgtt  atggagtac  tcatcaaga  tggctctga  480
cgtgtatca  aacagtgca  agagaacat  tatgctgtg  agacgctga  ggacttcca  540
tatgtggac  gtgatggca  ggaccaggg  gtgaatgtg  gggagaagg  caagcagct  600
gtggctttg  tgcgtgatg  ggatcggct  cgggaggag  gcgcccacg  gctcaagac  660
aaggagaaa  tggcacaga  tgccacggc  tcctcagca  ctgtgggct  tggaccacc  720
cccgaggcg  agcaggcat  gccacagag  agcggggag  aggagttgc  gctccagct  780
gccctggct  tgagcaagg  ggaggctga  cagcccccg  cctgcggcc  cgaggatga  840
gtccagctc  agctggccc  tagtttgag  cgagaggag  acgataagg  agagcggat  900
cgtcgtggg  atgacctga  gctgcagat  gcaatagag  agagcaaga  ggagactgg  960
ggcaaggag  agtcatctc  tatggatct  gctgacgtc  tcacaaccc  agcccctcc  1020
caggcctca  acccttggg  gggcccggc  tctgtgcct  ctgctgtcc  tgtggctgc  1080
gctgcctca  acccttggg  ggcacctgc  gtccctcca  ctgctgatc  ttggggtgg  1140
gcagccccc  cgccagcct  cggggatcc  tggaggcct  cagccccta  agggccctc  1200
gttgaccct  ggggtggga  cccagctcc  gcagctgga  aggggccca  atctgaccc  1260
tggggaagc  ctgatggtg  ggcccctgt  agtggaccc  catcttctg  cccctgggc  1320
cctgcccca  ctttctcag  cccttgggg  ggttcacct  caaagccca  cagcaatgg  1380
actgcagtt  ggggctttg  cactgagcc  gatgagttc  cagacttcg  ccgactccg  1440
actgccctg  caacctctg  gagcagcac  ggggaattg  agttgctcg  aggggaggt  1500
cctgctcgc  gccccgggg  attcgacat  agtggggtt  ggggatctc  ggctgagtc  1560
gtggggagt  cccctcctg  ggcaacccc  actcctacc  cgccaacac  gaagactcc  1620
gagtcattc  taggcccta  tgcagccct  gtggacttg  actcactgg  gagccgacc  1680
ggccctaca  cgccaggag  caaggcttc  aacccattc  ttccaagtg  agctccggc  1740
accggcccc  ccgtcacca  tcctttcca  ccagcaccc  ctgcaacgc  caccctgaa  1800
cagctccgt  tcagtcctg  gcccccagt  cctggagcg  cacccacct  catctctcc  1860
cttggtgga  gccctggcc  gccccccat  atgcccccg  gtcccccag  ccccaacac  1920
aaccccttc  tcctataat  cagggtagg  gggaggcct  gttcagctg  cttccccaa  1980
ttctgctcc  tgggagatc  gtgttgtga  tgcatgtga  atggggggg  ggcctcccc  2040
tcgtgcc  2047



<210> 529
<211> 575
<212> PRT
<213> Rattus norvegicus
<308> AAC33823
<400> 529

Met Ser Thr Ser Ser Leu Arg Arg Gln Met Lys Asn Ile Val His Asn 
  1               5                  10                  15
Tyr Ser Glu Ala Glu Ile Lys Val Arg Glu Ala Thr Ser Asn Asp Pro 
             20                  25                  30
Trp Gly Pro Ser Ser Ser Leu Met Ser Glu Ile Ala Asp Leu Thr Tyr 
         35                  40                  45
Asn Val Val Ala Phe Ser Glu Ile Met Ser Met Ile Trp Lys Arg Leu 
     50                  55                  60
Asn Asp His Gly Lys Asn Trp Arg His Val Tyr Lys Ala Met Thr Leu 
 65                  70                  75                  80
Met Glu Tyr Leu Ile Lys Thr Gly Ser Glu Arg Val Ser Gln Gln Cys 
                 85                  90                  95
Lys Glu Asn Met Tyr Ala Val Gln Thr Leu Lys Asp Phe Gln Tyr Val 
             100                105                110
Asp Arg Asp Gly Lys Asp Gln Gly Val Asn Val Arg Glu Lys Ala Lys 
         115                120                125
Gln Leu Val Ala Leu Leu Arg Asp Glu Asp Arg Leu Arg Glu Glu Arg 
     130                135                140
Ala His Ala Leu Lys Thr Lys Glu Lys Leu Ala Gln Thr Ala Thr Ala 
 145                150                155                160
Ser Ser Ala Ala Val Gly Ser Gly Pro Pro Pro Glu Ala Glu Gln Ala 
                 165                170                175
Trp Pro Gln Ser Ser Gly Glu Glu Glu Leu Gln Leu Gln Leu Ala Leu 
             180                185                190
Ala Met Ser Lys Glu Glu Ala Asp Gln Pro Pro Ser Cys Gly Pro Glu 
         195                200                205
Asp Asp Val Gln Leu Gln Leu Ala Leu Ser Leu Ser Arg Glu Glu His 
     210                215                220
Asp Lys Glu Glu Arg Ile Arg Arg Gly Asp Asp Leu Arg Leu Gln Met 
 225                230                235                240
Ala Ile Glu Glu Ser Lys Arg Glu Thr Gly Gly Lys Glu Glu Ser Ser 
                 245                250                255
Leu Met Asp Leu Ala Asp Val Phe Thr Thr Pro Ala Pro Pro Gln Ala 
             260                265                270
Ser Asp Pro Trp Gly Gly Pro Ala Ser Val Pro Thr Ala Val Pro Val 
         275                280                285
Ala Ala Ala Ala Ser Asp Pro Trp Gly Ala Pro Ala Val Pro Pro Ala 
     290                295                300
Ala Asp Pro Trp Gly Gly Ala Ala Pro Thr Pro Ala Ser Gly Asp Pro 
 305                310                315                320
Trp Arg Pro Ala Ala Pro Thr Gly Pro Ser Val Asp Pro Trp Gly Gly 
                 325                330                335
Thr Pro Ala Pro Ala Ala Gly Glu Gly Pro Thr Ser Asp Pro Trp Gly 
             340                345                350
Ser Ala Asp Gly Gly Ala Pro Val Ser Gly Pro Pro Ser Ser Asp Pro 
         355                360                365
Trp Ala Pro Ala Pro Ala Phe Ser Asp Pro Trp Gly Gly Ser Pro Ala 
     370                375                380
Lys Pro Ser Ser Asn Gly Thr Ala Val Gly Gly Phe Asp Thr Glu Pro 
 385                390                395                400
Asp Glu Phe Ser Asp Phe Asp Arg Leu Arg Thr Ala Leu Pro Thr Ser 
                 405                410                415
Gly Ser Ser Thr Gly Glu Leu Glu Leu Leu Ala Gly Glu Val Pro Ala 
             420                425                430
Arg Ser Pro Gly Ala Phe Asp Met Ser Gly Val Gly Gly Ser Leu Ala 
         435                440                445
Glu Ser Val Gly Ser Pro Pro Pro Ala Ala Thr Pro Thr Pro Thr Pro 
     450                455                460
Pro Thr Arg Lys Thr Pro Glu Ser Phe Leu Gly Pro Asn Ala Ala Leu 
 465                470                475                480
Val Asp Leu Asp Ser Leu Val Ser Arg Pro Gly Pro Thr Pro Pro Gly 
                 485                490                495
Ala Lys Ala Ser Asn Pro Phe Leu Pro Ser Gly Ala Pro Ala Thr Gly 
             500                505                510
Pro Ser Val Thr Asn Pro Phe Gln Pro Ala Pro Pro Ala Thr Leu Thr 
         515                520                525
Leu Asn Gln Leu Arg Leu Ser Pro Val Pro Pro Val Pro Gly Ala Pro 
     530                535                540
Pro Thr Tyr Ile Ser Pro Leu Gly Gly Gly Pro Gly Leu Pro Pro Met 
 545                550                555                560
Met Pro Pro Gly Pro Pro Ala Pro Asn Thr Asn Pro Phe Leu Leu 
                 565                570                575



<210> 530
<211> 2620
<212> DNA
<213> Homo sapiens
<308> NM_013333
<400> 530

aattctttc  tttcagagt  gagcaaact  tgtctcaag  aggtgtgcg  tgcaggtag  60
tgatgtggc  aggatttga  cccacattt  atattcttt  ccattagat  ccatttttc  120
tatctctta  ttctcagcg  caggtctct  tttgtttct  ggcctcttt  ttccttggc  180
tcctgcctc  ctgtcttcc  atgttcttg  atctgctgc  gcctgtgtt  ttctcattg  240
gtctctgcc  agctccctc  gcccaggtt  ctatgtgtc  ctttctgtc  gaactgtct  300
ctatttctt  tcagtcccc  tctctgcat  tgttacatc  tctcttcat  ttaatgtat  360
aggctgggg  tgttttggg  ctccagaga  ttacttttt  actagctac  tctgtcttc  420
ggtgcctgg  tttctggcc  gaggtggaa  cagaggcca  cctctctcc  tcatcccta  480
ctcccctgg  cttacatca  ggcggggct  tgaaaatct  cctctgtgg  ttcttggag  540
cgcatagat  ggtgatcag  gctggctct  gaaccaggc  gctccagga  taaggagcc  600
agtctttgc  tgcagtgtt  aaaaaggta  tgtccctct  gtgctgagc  agcacctgg  660
acacagcag  gacccaggc  gtggggctg  taggttcct  atctctcct  agccttggg  720
ttccgctat  cttgggacg  ctggtcttc  ggcttcccc  gttcttcct  ccgccctgg  780
tgcggtgac  tgccagcac  tgccgcagc  ttcgtccgg  agtcgcccc  tctctccac  840
caatcggcc  tgtgcccct  gctgctgca  ccgggcacc  tgtcgacct  gtccttgag  900
cgccagatg  agaacatcg  ccacaacta  tcagaggcg  agatcaagg  tcgagaggc  960
acgagcaat  acccctggg  cccatccag  tccctcatg  cagagattg  cgacctcac  1020
tacaacgtt  tcgccttct  ggagatcat  agcatgatc  ggaagcggc  caatgacca  1080
ggcaagaac  ggcgtcacg  ttacaaggc  atgacgctg  tggagtacc  catcaagac  1140
ggctcggag  gcgtgtcgc  gcagtgcaa  gagaacatg  acgccgtgc  gacgctgaa  1200
gacttccag  acgtggacc  cgacggcaa  gaccagggc  tgaacgtgc  tgagaaagc  1260
aagcagctg  tggccctgc  gcgcgacga  gaccggctg  gggaagagc  ggcgcacgc  1320
ctcaagacc  aggaaaagc  ggcacagac  gccacggcc  catcagcag  tgtgggctc  1380
ggcccccct  ccgaggcgg  gcaggcgtg  ccgcagagc  gcggggagg  ggagctgca  1440
ctccagctg  ccctggcca  gagcaagga  gaggccgac  aggaggagc  gatccgtcg  1500
ggggatgac  tgcggctgc  gatggcaat  gaggagagc  agagggaga  tgggggcaa  1560
gaggagtcg  ccctcatgg  ccttgctga  gtcttcacg  ccccagctc  tgccccgac  1620
acagacccc  gggggggcc  agcacccat  gctgctgcc  tccccacgg  tgcccccac  1680
tcggacccc  ggggcggcc  ccctgtccc  ccagctgct  atccctggg  aggtccagc  1740
cccacgccg  cctctgggg  cccctggag  cctgctgcc  ctgcaggac  ctcagttga  1800
ccttggggt  ggaccccag  ccctgcagc  ggggagggg  ccacgcctg  tccatgggg  1860
agttccgat  gtggggtcc  ggtcagtgg  ccctcagcc  ccgatccct  gacaccggc  1920
ccggccttc  cagatccct  gggagggtc  cctgccaag  ccagcacca  tggcacaac  1980
gcagccggg  gattcgaca  ggagcccga  gagttctct  actttgacc  actccgcac  2040
gcactgccg  cctccggga  cagcgcagg  gagctggag  tgctggcag  agaggtgcc  2100
gcccgaagc  ctggggcgt  tgacatgag  ggggtcagg  gatctctgg  tgaggctgt  2160
ggcagcccc  cacctgcag  cacaccaac  cccacgccc  ccacccgga  gacgccgga  2220
tcattcctg  ggcccaatg  agccctcgt  gacctggac  cgctggtga  ccggccggg  2280
cccacgccg  ctggagcca  ggcctccaa  cccttcctg  caggcggag  cccagccac  2340
ggcccttcc  tcaccaacc  cttccagcc  gcgcctccc  cgacgctca  cctgaacca  2400
ctccgtctc  gtcctgtgc  tcccgtccc  ggagcgcca  ccacgtaca  ctctcccct  2460
ggcgggggc  ctggcctgc  ccccatgat  cccccgggc  ccccggccc  caacactaa  2520
cccttcctc  tataatcca  ggcggaagg  ggcctggct  catccggct  ccccattcc  2580
gctccctgg  agatcagtg  tgtgagtgc  tgtgaaatgg  2620



<210> 531
<211> 3845
<212> DNA
<213> Rattus norvegicus
<308> AF019043
<400> 531

gtctgcaga  gatggagct  acttattca  agttaaaga  gtctccagc  tgggaggct  60
agagtggaa  ttcaccggc  cagcggtta  tcaggagtg  atccctgca  gaaagcccc  120
cctgcctag  ctcagcagg  cactcattc  ctgactcag  cgcttagca  acacagtgt  180
caccaccca  acgctaggc  atgcatcta  actgacatg  cccctgccc  actgagggg  240
agacactgc  tccagggag  ctcacttgc  atgggcttg  tttcttccc  agggctact  300
ttcaaggaa  tcttgtgtt  accacaggc  gaggcttcc  acaacttct  caaattcac  360
cagtagaga  caggccatg  tgctctttc  tgcagccag  cccctgaca  ggggtgaga  420
aacaggtga  caggccaga  tcagtgtcc  ggcccagca  ctgcctttt  ggaagtcag  480
tctgagtag  cgggcctgg  taaaatcct  gcgatgcca  tttctggtt  tgaccttgc  540
caggtcatc  cctctctga  cacctgttt  cctcctcta  aagtaagtg  tgacaagac  600
cagtttttc  tccctaagg  gtccgaaaa  gggagggcc  cagctcctc  tgccgaatt  660
ggcacgagg  gggctgcgg  ctgcgtccc  attcattgc  gtggtctgc  gggttgggg  720
ccagtgttt  cggagtcat  gaggcgctg  tcccggtca  caataagct  caggacgtc  780
tcaacaccg  gggcgccga  atcatccag  tgcctcaga  tgtcgtagt  ggaactcag  840
gcagtggaa  gagctcagt  ctggaaagc  tagtgggga  ggaccttct  cccagaggg  900
ctggtgtgg  cacccggag  cctcttatt  tgcagctgg  ccacgtttc  ccagaagat  960
aaagaaaaa  aacaggaga  gaaaatgac  ctgctacat  gaaaaactc  agacacctt  1020
ctaaaggag  tgaagcaga  gaatggggt  aatttcttc  caccaaaaa  aagctttac  1080
cagattttg  tgaaattcg  caagaaatt  aaaatgaaa  tgaaagaat  tcaggaaat  1140
ataagggag  aagccctga  ccaatccat  tcaaggttt  ctcgcccaa  gttgtcaac  1200
tgacgcttg  ggatttacc  ggaatgacc  aagtacctg  aggtgatca  cccaaggat  1260
ttgagcttc  aatcagaga  cttattctt  ggttcatca  taatcccaa  tccattatc  1320
ttgctgtca  tgctgcaaa  acagatatg  caacgtcag  ggcacttaa  atttccaga  1380
aggtagatc  agatgggcg  agaactcta  ctgtaatca  caagcttga  ctcatggat  1440
cgggtactg  tgccatgga  gtattgatg  gaagggtta  tccagtcaa  cttggaata  1500
ttggagtag  taacaggag  caactggac  ttaacaata  gaagagtgt  actgattca  1560
tccgtgatg  gtatgcttt  cttcaaaag  agtacccat  tctggccaa  agaaatgga  1620
caaagtatc  tgctaggac  ctgaatagg  tacttatgc  tcatatcag  gactgttta  1680
cagagctga  aacaagaat  aatgtctta  ctgctcagt  tcagtctct  ctaaatagc  1740
atggtgagc  cgtggatga  aaaagtgct  ctttactcc  gctcattac  aagtttgcc  1800
cagagtatt  taacactat  gaaggaacg  caaagtaca  cgaaacttc  gagctatgt  1860
gtggtgcta  gatttgtta  attttccat  agacttttg  gcgaacctt  gaatctgtt  1920
atccactag  tggccttaa  actattgac  tcttgactg  cattagaaa  gctactggc  1980
cccgtccag  tttatttgt  cctgaagtt  catttgagt  actggtcaa  cgtcagatt  2040
agcgtctag  ggagcccag  ctccgctgt  tggagctgg  ccacgagga  atgcagagg  2100
tcattcagc  ctgtagcaa  tacagcaca  aggaactgt  acggttccc  aaactccat  2160
atgccatag  tgaagtagt  acttgtctt  ttcgtaaaa  gttgcccgt  acaaatgaa  2220
tggtacata  cttagtggc  attgagcta  catatatca  cacaaaaca  cccgacttt  2280
ctgatgcct  tgggctaat  aacaataac  tagaggaac  aagaagaaa  agactagca  2340
gagaactac  ttcagctgt  tcgcgagac  agtcttcta  agttccaag  gctttggca  2400
ctgcctccc  ggagccctc  cctgccgct  ctgccgagg  tgatggcaa  ttaattcag  2460
acaacagaa  agaaactaa  aatgttgca  ctgcaggtg  tggaattgg  gatggtggt  2520
gaattggag  tggtggtca  gaaccgaca  caggcaact  gagaggaat  ctgaaaact  2580
caaaagctg  agaattact  gctgaagaa  aatcaaaac  aattccaat  atgccagca  2640
gtccacaaa  aggccatgc  gtcaatttg  tagatgtgc  agttccagt  gcacgaaaa  2700
tgtctgccc  agaacagcg  gattgtgag  ttattgaaa  actcatcaa  tcatatttt  2760
taattgtca  aaagaatat  caagacagc  tcccaaagg  agtaatgca  tttttggtt  2820
atcatgtga  agatactct  cagagtgaa  tagtagggc  gctgtataa  tcatcctta  2880
tagatgacc  tctgactga  tccgaggac  tggcacagc  aagaaaaga  gcggctgac  2940
tgctgaagg  attacaagg  gccagtcaa  ttattgctg  aatccgaga  actcatctt  3000
ggtgaacag  actgtttgg  cttctacac  ttgctgact  gaacctact  gctactgcc  3060
acctgagta  aagtttatt  atggacttt  gtgtatcgc  gtgtatgaa  ttgcttgtg  3120
gaagactgg  tataagctg  aaagtatat  attcattac  agacaaatc  catgtttaa  3180
tcacatttt  caagtttcc  atgatgtat  tcaagtctg  ccgtttcag  caaacttac  3240
agaacaatt  atgttctag  tgtacaaag  agtttgcct  tgcatatga  gacccgcgt  3300
acctttttt  agtcttaaa  ctgcagccg  agtcctcaa  gaggaagct  caggacatt  3360
catgactat  atgcatgca  tatttatat  gactgacct  gcttcaaaa  gtggagcct  3420
gcgagttcc  cacataatc  atgtatcca  ctatccttc  tttttatag  cttaaaaaa  3480
aaacaaaat  ctgtaactt  tgcagtttt  ggaaaaata  aagatctga  agactcata  3540
agatgtagg  acagactgt  taattaatg  ctcctgagt  tatactgcc  taatgttag  3600
aagtaaaat  tgctttgat  caaaataag  ctgaaaata  aaattgact  cctgcatta  3660
aaataacta  taggaactt  cttagtaac  ataactggt  ctgttagtt  ctaaatgac  3720
cagtgacaa  ctaaatttc  ctaatttac  agtacatcg  ttgcagtcc  gatgcacct  3780
agggtgggg  gctgactct  gggctccga  actcagtta  gtgagacct  aaagtctac  3840
ctgtt  3845



<210> 532
<211> 848
<212> PRT
<213> Rattus norvegicus
<308> Q08877
<400> 532

Met Gly Asn Arg Glu Met Glu Glu Leu Ile Pro Leu Val Asn Arg Leu 
  1               5                  10                  15
Gln Asp Ala Phe Ser Ala Leu Gly Gln Ser Cys Leu Leu Glu Leu Pro 
             20                  25                  30
Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
         35                  40                  45
Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
     50                  55                  60
Thr Arg Arg Pro Leu Val Leu Gln Leu Val Thr Ser Lys Ala Glu Tyr 
 65                  70                  75                  80
Ala Glu Phe Leu His Cys Lys Gly Lys Lys Phe Thr Asp Phe Asp Glu 
                 85                  90                  95
Val Arg His Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Met Asn 
             100                105                110
Lys Gly Ile Ser Ser Val Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
         115                120                125
Val Leu Asn Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Lys Val Pro 
     130                135                140
Val Gly Asp Gln Pro Pro Asp Ile Glu Tyr Gln Ile Arg Asp Met Ile 
 145                150                155                160
Met Gln Phe Ile Thr Arg Glu Asn Cys Leu Ile Leu Ala Val Thr Pro 
                 165                170                175
Ala Asn Thr Asp Leu Ala Asn Ser Asp Ala Leu Lys Leu Ala Lys Glu 
             180                185                190
Val Asp Pro Gln Gly Leu Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
         195                200                205
Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
     210                215                220
Leu Pro Leu Arg Arg Gly Tyr Val Gly Val Val Asn Arg Ser Gln Lys 
 225                230                235                240
Asp Ile Asp Gly Lys Lys Asp Ile Lys Ala Ala Met Leu Ala Glu Arg 
                 245                250                255
Lys Phe Phe Leu Ser His Pro Ala Tyr Arg His Ile Ala Asp Arg Met 
             260                265                270
Gly Thr Pro His Leu Gln Lys Val Leu Asn Gln Gln Leu Thr Asn His 
         275                280                285
Ile Arg Asp Thr Leu Pro Asn Phe Arg Asn Lys Leu Gln Gly Gln Leu 
     290                295                300
Leu Ser Ile Glu His Glu Val Glu Ala Phe Lys Asn Phe Lys Pro Glu 
 305                310                315                320
Asp Pro Thr Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                 325                330                335
Ala Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Val Asp 
             340                345                350
Thr Leu Glu Leu Ser Gly Gly Ala Lys Ile Asn Arg Ile Phe His Glu 
         355                360                365
Arg Phe Pro Phe Glu Ile Val Lys Met Glu Phe Asn Glu Lys Glu Leu 
     370                375                380
Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Ile Arg Thr 
 385                390                395                400
Gly Leu Phe Thr Pro Asp Met Ala Phe Glu Ala Ile Val Lys Lys Gln 
                 405                410                415
Ile Val Lys Leu Lys Gly Pro Ser Leu Lys Ser Val Asp Leu Val Met 
             420                425                430
Gln Glu Leu Ile Asn Thr Val Lys Lys Cys Thr Lys Arg Leu Ala Asn 
         435                440                445
Phe Pro Arg Leu Cys Glu Glu Thr Glu Arg Ile Val Ala Asn His Ile 
     450                455                460
Arg Glu Arg Glu Gly Lys Thr Lys Asp Gln Val Leu Leu Leu Ile Asp 
 465                470                475                480
Ile Gln Val Ser Tyr Ile Asn Thr Asn His Glu Asp Phe Ile Gly Phe 
                 485                490                495
Ala Asn Ala Gln Gln Arg Ser Ser Gln Val His Lys Lys Ser Thr Ile 
             500                505                510
Gly Asn Gln Val Ile Arg Lys Gly Trp Leu Thr Val Ser Asn Ile Gly 
         515                520                525
Ile Met Lys Gly Gly Ser Lys Gly Tyr Trp Phe Val Leu Thr Ala Glu 
     530                535                540
Ser Leu Ser Trp Tyr Lys Asp Asp Glu Glu Lys Glu Lys Lys Tyr Met 
 545                550                555                560
Leu Pro Leu Asp Asn Leu Lys Val Arg Asp Val Glu Lys Gly Phe Met 
                 565                570                575
Ser Ser Lys His Val Phe Ala Leu Phe Asn Thr Glu Gln Arg Asn Val 
             580                585                590
Tyr Lys Asp Tyr Arg Ser Leu Glu Leu Ala Cys Asp Ser Gln Glu Asp 
         595                600                605
Val Asp Ser Trp Lys Ala Ser Leu Leu Arg Ala Gly Val Tyr Pro Asp 
     610                615                620
Lys Ser Phe Thr Glu Asn Asp Glu Asn Gly Gln Ala Glu Asn Phe Ser 
 625                630                635                640
Met Asp Pro Gln Leu Glu Arg Gln Val Glu Thr Ile Arg Asn Leu Val 
                 645                650                655
Asp Ser Tyr Met Ser Ile Ile Asn Lys Cys Ile Arg Asp Leu Ile Pro 
             660                665                670
Lys Thr Ile Met His Leu Met Ile Asn Asn Val Lys Asp Phe Ile Asn 
         675                680                685
Ser Glu Leu Leu Ala Gln Leu Tyr Ser Ser Glu Asp Gln Asn Thr Leu 
     690                695                700
Met Glu Glu Ser Val Glu Gln Ala Gln Arg Arg Asp Glu Met Leu Arg 
 705                710                715                720
Met Tyr Gln Ala Leu Lys Glu Ala Leu Ala Ile Ile Gly Asp Ile Asn 
                 725                730                735
Thr Val Thr Val Ser Thr Pro Ala Pro Pro Pro Val Asp Asp Ser Trp 
             740                745                750
Leu Gln His Ser Arg Arg Ser Pro Pro Pro Ser Pro Thr Thr Gln Arg 
         755                760                765
Arg Leu Thr Leu Ser Ala Pro Leu Pro Arg Pro Ala Ser Ser Arg Gly 
     770                775                780
Pro Ala Pro Ala Ile Pro Ser Pro Gly Pro His Ser Gly Ala Pro Pro 
 785                790                795                800
Val Pro Phe Arg Pro Gly Pro Leu Pro Pro Phe Pro Asn Ser Ser Asp 
                 805                810                815
Ser Tyr Gly Ala Pro Pro Gln Val Pro Ser Arg Pro Thr Arg Ala Pro 
             820                825                830
Pro Ser Val Pro Arg Phe Gly Ala Val Lys Glu Glu Ala Val Glu Pro 
         835                840                845



<210> 533
<211> 2493
<212> DNA
<213> Homo sapiens
<308> AF000430
<400> 533

ggaggcgaa  tgtgggccc  ggccattca  tgccgtggc  ggcgggcac  ggggccccg  60
gttttcaga  tcatggagg  gctaattcc  gtcataaac  agctccagg  cgtcttcaa  120
acggtgggc  ccgacatca  ccagctgcc  caaatcgtc  tagtgggaa  gcagagcag  180
ggaaagagc  cagtgctag  aagcctggt  gggagggac  tgcttccca  aggtactgg  240
attgtcacc  ggagacctc  cattctgca  ctggtccat  tgacacaag  agataaacg  300
aaaacaaca  gagaagaaa  tggggtgga  gcagaagaa  ggggtaaat  tcttcacac  360
aaaaataag  tttacacgg  ttttgatga  attcgacaa  aaattgaaa  tgaaacaga  420
agaatttca  gaaataata  gggagtaag  cctgaacca  ttcatctta  gattttttc  480
cccaacgtt  tcaatttga  acttgtgga  ttgccagga  tgaccaagg  gcctgtagg  540
gatcaacct  aggatattg  gcttcaaat  agagagctc  ttcttcggt  catcagtaa  600
cctaattcc  ttatcctcg  tgtcactgc  gctaataca  atatggcaa  atcagaggc  660
cttaaaatt  caagagagg  agatccaga  ggtcgcaga  ccctagctg  aatcactaa  720
cttgatctc  tggatgcgg  tactgatgc  atggatgta  tgatgggaa  ggttattcc  780
gtcaaactt  gaataattg  agtagttaa  aggagccag  tagatatta  caacaagaa  840
agtgtaact  attcaatcc  tgatgagta  gcttttctt  aaaagaaat  tccatctct  900
gccaataga  atggaacaa  gtatcttgc  aggactcta  acaggttac  gatgcatca  960
atcagagat  gtttaccag  gttgaaaac  agaataaat  ttctagctg  tcagtatca  1020
tctcttcta  atagctacg  tgaacccgt  gatgataaa  gtgctactt  actccaact  1080
attaccaaa  ttgccacag  atattgtaa  actattgaa  gaactgcaa  atatattga  1140
acttcggag  tatgcggtg  tgctagaat  tgttatatt  tccatgaga  ttttgggcg  1200
accttagaa  ctgttgatc  acttggtgg  cttaacact  ttgacattt  gactgccat  1260
agaaatgct  ctggtcctc  tcctgcttt  tttgtgcct  aggtttcat  tgagttact  1320
gtgaagcgg  aaatcaaac  tctagaaga  cccagcctc  gctgtgtgg  actggttca  1380
gaggaaatg  aaaggatca  tcagcactg  agcaattac  gtacacagg  attgttacg  1440
tttcctaaa  ttcatgatg  catagttga  gtggtgact  gtcttcttc  taaaaggtt  1500
cctgttaca  atgaaatgg  ccataactt  gtggcaatt  aactggctt  tatcaacac  1560
aaacatcca  actttgctg  tgcttgtgg  ctaatgaac  ataatatag  ggaacaaag  1620
agaaacagg  tagccagag  attaccttc  gctgtatca  gagacaagt  ttctaaagt  1680
ccaagtgct  tggcacctg  ctcccagga  ccctccccc  ctgcttctg  tgaggctga  1740
ggcaagtta  ttcaggaca  cagaagaga  actaaaaat  ttgcatctg  aggtggtgg  1800
gttggagat  gtgttcaag  accaaccac  ggcaactgg  gaggaatgc  gaaaacttc  1860
aaagctgaa  agttattag  agaagaaaa  tcaaaaccc  ttccaatta  gccagccag  1920
ccacaaaaa  gtcatgccg  gaacctgct  gatgtgcca  ttcctgttg  acgaaaact  1980
tctgctcgg  aacagcgag  ttgtgaggt  attgaacga  tcattaaat  atattttct  2040
attgtcaga  agaatattc  agacagtgt  ccaaaggca  taatgcatt  tttggttaa  2100
catgtgaaa  acactcttc  gagtgagct  gtaggccag  tgtataaat  atccttatt  2160
gatgatctt  tgacagaat  tgaggacat  gcacagcgc  ggaaagaag  agctgatat  2220
ctaaaggca  tacaaggag  cagtcaaat  attgctgaa  tccgggaga  tcatctttg  2280
tgaagagaa  tatgtaata  tgagacttt  ttgactcaa  acttgctag  tactgccta  2340
ctgagtaga  tcttattta  gaactcctg  gtattgcaa  ggtatgaat  tgctcatgt  2400
gagactggc  ataaactga  aagtgtatt  caaattgca  aacacatca  acatttaat  2460
caaataata  atggctgtt  ctaaaaaaa  aaa  2493



<210> 534
<211> 737
<212> PRT
<213> Homo sapiens
<308> AF000430
<400> 534

Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn 
  1               5                  10                  15
Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly 
             20                  25                  30
Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg 
         35                  40                  45
Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile 
     50                  55                  60
Leu Gln Leu Val His Val Thr Gln Glu Asp Lys Arg Lys Thr Thr Gly 
 65                  70                  75                  80
Glu Glu Asn Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr 
                 85                  90                  95
Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu 
             100                105                110
Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu 
         115                120                125
Pro Ile His Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu 
     130                135                140
Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys 
 145                150                155                160
Asp Ile Glu Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn 
                 165                170                175
Pro Asn Ser Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala 
             180                185                190
Thr Ser Glu Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg 
         195                200                205
Arg Thr Leu Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr 
     210                215                220
Asp Ala Met Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly 
 225                230                235                240
Ile Ile Gly Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys 
                 245                250                255
Ser Val Thr Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys 
             260                265                270
Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr 
         275                280                285
Leu Asn Arg Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu 
     290                295                300
Lys Thr Arg Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn 
 305                310                315                320
Ser Tyr Gly Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu 
                 325                330                335
Ile Thr Lys Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala 
             340                345                350
Lys Tyr Ile Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr 
         355                360                365
Ile Phe His Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu 
     370                375                380
Gly Gly Leu Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr 
 385                390                395                400
Gly Pro Arg Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu 
                 405                410                415
Val Lys Arg Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val 
             420                425                430
Glu Leu Val His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn 
         435                440                445
Tyr Ser Thr Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile 
     450                455                460
Val Glu Val Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn 
 465                470                475                480
Glu Met Val His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr 
                 485                490                495
Lys His Pro Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile 
             500                505                510
Glu Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val 
         515                520                525
Ser Arg Asp Lys Ser Ser Lys Val Pro Ser Ala Leu Ala Pro Ala Ser 
     530                535                540
Gln Glu Pro Ser Pro Ala Ala Ser Ala Glu Ala Asp Gly Lys Leu Ile 
 545                550                555                560
Gln Asp Ser Arg Arg Glu Thr Lys Asn Val Ala Ser Gly Gly Gly Gly 
                 565                570                575
Val Gly Asp Gly Val Gln Glu Pro Thr Thr Gly Asn Trp Arg Gly Met 
             580                585                590
Leu Lys Thr Ser Lys Ala Glu Glu Leu Leu Ala Glu Glu Lys Ser Lys 
         595                600                605
Pro Ile Pro Ile Met Pro Ala Ser Pro Gln Lys Gly His Ala Val Asn 
     610                615                620
Leu Leu Asp Val Pro Val Pro Val Ala Arg Lys Leu Ser Ala Arg Glu 
 625                630                635                640
Gln Arg Asp Cys Glu Val Ile Glu Arg Leu Ile Lys Ser Tyr Phe Leu 
                 645                650                655
Ile Val Arg Lys Asn Ile Gln Asp Ser Val Pro Lys Ala Val Met His 
             660                665                670
Phe Leu Val Asn His Val Lys Asp Thr Leu Gln Ser Glu Leu Val Gly 
         675                680                685
Gln Leu Tyr Lys Ser Ser Leu Leu Asp Asp Leu Leu Thr Glu Ser Glu 
     690                695                700
Asp Met Ala Gln Arg Arg Lys Glu Ala Ala Asp Met Leu Lys Ala Leu 
 705                710                715                720
Gln Gly Ala Ser Gln Ile Ile Ala Glu Ile Arg Glu Thr His Leu Trp 
                 725                730                735
Ter 
             740



<210> 535
<211> 6628
<212> DNA
<213> Rattus norvegicus
<308> AF019628
<400> 535

agcagctgg  ctcccacca  cctaaaaat  atccactcg  cgctgtctg  tgacccggg  60
ggaaaactt  tcatcccat  gagtgtgtg  gctcctcgg  ttgctccag  gagatcccc  120
accgctttg  ggagtcagt  actgagttc  gtggacttg  ttgaaattt  catcttcag  180
ctgtgcgca  gcggttgga  ggtagatca  gtgcaccag  agggggact  agttcctga  240
ccaaagtca  ggctaatca  ctaagaaga  atgagcctt  ccttctgtg  taacaacat  300
tcctcctac  acatctacc  tggtgttct  caaaacccc  gctttgtgg  cgcactcaa  360
ctggtccct  acgtcttcc  gctgtttat  acctttccg  tcctgttca  tggatgggg  420
agccaaagc  caaaagtgc  aattcatca  aacacatgg  ttcattttc  tggacacaa  480
ctgagatgg  ttctgacgt  tgcactcct  tttgtgcat  tctgcgaga  agcagaagg  540
attgtttca  actcgcaac  ggcgtccag  catctccac  ttttcatgc  ggctgtgat  600
ggatttgtc  ccaccacca  atccattgt  tattaccac  acattgaaa  atcaaactt  660
cctaaatta  ttttagctt  attcctgta  tgggtcatg  ccttcatta  aaagacaat  720
aagttggtc  aatactggc  gttggggtg  ggaatgtca  acctgcgct  ctgcatcac  780
ggagtgatg  tcatcttga  tggactgct  atggctgtg  agatcaatg  catccgggt  840
cgaagatat  ttttcttca  gaatcctca  aaagtgaag  ctccagagg  cctccagga  900
ctgggcgtg  ggttcctcc  gccgtttgt  aatttgctg  ccaaagcta  ttactggtg  960
atgaacacg  ttatcatat  agctcacag  aaacctatt  atctgaagg  gatcggaaa  1020
ttgccgata  caatgaggg  ggtgacgaa  tatgtttgc  tgaaggagg  ctacgaaga  1080
cagaagaaa  aggctgcgg  tcatccgaa  cggactccc  ccatatggc  ggccatgta  1140
agggctttt  ggagaccga  cctgctgag  agcacgttc  gctacttgg  tgacttgct  1200
ggctttgcc  gccctcttt  tatttccgg  atcgtccag  gtgtgaatg  accgaagaa  1260
aacacgacg  gattttcag  gacactctc  tcaaaggag  ttctggaaa  tgcccatgt  1320
ctggctgtc  tgctcttcc  ggccctcat  ctgcaaaga  catttttgc  ggcttcgta  1380
tatgtgacc  tagagaccg  catcaacct  cgtggggct  tgctggcta  gatctacaa  1440
aaaatcctt  gactgtcta  ttctaacct  tccatgggc  agatgaccc  gggacagat  1500
aacaacttg  ttgccatag  aaccaatca  ctcatgtgg  tcttgttcc  gtgtcccaa  1560
ctgtgggcc  tgcccgttc  gatcataat  ggggtgatc  tgctctata  tctgcttgg  1620
tcaagcgca  tggtaggcg  ggcggtcat  gtgctcctc  caccgattc  gtacttcat  1680
gccacgaag  tggcggagg  tcagaagag  actctggat  attccaccg  gaggctgaa  1740
aagacaaac  agatactga  aggcatcaa  ctccttaag  tgtatgcct  ggagcacat  1800
ttctgcaag  gcgtggaag  gactagaat  aaggagctc  ccagcctca  aaccttcgc  1860
ctctacacg  cgctttcca  cttcatgaa  gcagccatt  ccatcgcag  cgttcttgc  1920
acatttgtg  cccatgcct  tgccagtgg  aacaacctg  aacccgcag  ggcctttgc  1980
tctctgtct  tcttccaca  cctcgtcac  ccgctcttc  tgctgtcca  ggtggtcag  2040
ttcgcagtg  aagccatca  cagcgttca  aagctgaat  agtttctct  gagcgatga  2100
attggcgag  acagctgga  gactgggga  gggacgctg  cttttgagt  ctgtaagaa  2160
cacaccgga  tgcaatcaa  accgataaa  aggaagcag  ctggaaggt  ccacctgga  2220
aactacgag  aggcgcggc  tcttcggcc  gctgagact  aagatgttg  cataaaggt  2280
acgaacgga  acttctcat  gggcagtgg  ttagccaca  tatccaata  tgacattcg  2340
attccaaca  gtcagctaa  catgattgt  ggtcaggtg  gttgtggca  atcgtctct  2400
ctccttgcc  tccttggtg  gatgcagac  ctggaagga  aagtttact  gaacaatgt  2460
aatgaatct  agccttctt  tgaagcaac  cgaagcaga  gcaggtact  tgtggctta  2520
gctgcccag  agccttggc  cctcaatgc  acggtcgag  aaaacatca  ttttggaag  2580
tctttcaac  gacagaggt  caaggctgt  accgatgcc  gctctctgc  gccagacat  2640
gatttgtta  cctttggag  ccaaactga  attggagag  ggggtatca  cctgagtgg  2700
ggtcagagg  agagaatct  cgtggcccg  gcactctac  agaacacca  tattgtctt  2760
ttggacgat  cattctccg  tctggacat  cacctgagc  accacttga  gcaggaagg  2820
atcctgaag  ttctccagg  cgacaagag  acggtcgtc  ttgtgactc  caaactaca  2880
tacctgacg  acgcggact  gatcatagc  atgaaggat  ggagtgtgt  aagggaagg  2940
actttgaaa  acatccaga  caaagacgt  gagctctat  aacactgga  aaccctcat  3000
aatcggcaa  atcaggaat  agaaaagga  atggaagcc  accaaacaa  gctggagag  3060
aagactctc  gaagagcta  gtactcaag  gaggccaaa  cacagatgg  ggatgaaga  3120
gaagaggag  aggaggagg  agatgagga  gacaacatg  caactgtaa  gaggctcag  3180
acgaagatg  cctggaaga  ctgttggtg  tacctcact  caggagggt  tttcctgct  3240
ttcctcatg  tcttctcta  gcttttgaa  cactctgtg  tcgtggcca  cgactactg  3300
ctagctacg  ggacctccg  gtacagtat  aacgaccca  ggaaagctg  ccagacctt  3360
tatgtggct  ggttcagca  cctctgtgg  gcgggcatt  tcctttgcc  cgtcacctc  3420
ctcactgta  aatggatgg  tctcaccgc  gccaagaac  tccaccaca  tctcctcaa  3480
aagataatt  tgggcccaa  aaggttctt  gataccacg  ccctgggac  gatcctcaa  3540
cggttttct  ctgatacca  catcatcga  caacatatc  ctccgacct  ggagtcgct  3600
acccgctct  ccctgctct  cctgtcggc  attgggatg  tctcctatg  tacacccgt  3660
tttctcatc  ctcttgcgc  cctgggcgt  gccttttat  tcatccaga  atacttccg  3720
gttgcctct  aggatctcc  ggaactcga  gacagcacc  agctccccc  gctttgtca  3780
ttctcagaa  cagctgaag  gcttaccac  atccgggcc  tcaggcatg  aaccagatt  3840
aagcaacgc  tgctggagc  gacagacac  aacaacatt  cctacttat  tctctccgc  3900
gccaacaga  ggctggagg  caggacgga  tacctggga  cttgcattg  tctgacggc  3960
tccattgca  ccatcagtg  ctcttccaa  tctggacta  tgggcttgg  ccttctgta  4020
gccctcacg  taaccaatt  cctgaattg  gttgtaagg  acttggccg  cctcgaagt  4080
cagatgggc  cagtgaaga  agtgaacag  ttcttaact  tggagtctg  gaactatga  4140
ggcaccatg  atccttctc  agtcccaga  cattggcca  aggaaggtg  gatcaagat  4200
cacgatcta  gcgtcagat  tgaaaataa  ctgaagccc  ttctgaaac  tgtcaaggc  4260
tacatcaag  ctgggcaga  ggtgggcat  tgtggtcgc  ccggtagtg  gaagtcctc  4320
ctatctctg  ctttcttca  aatggtcga  atatttgat  gaaagatag  cattgatgg  4380
atagacatt  ccaagctgc  cttgcacac  ctccgctct  gactgtcca  cattctcca  4440
gacccaatc  tgttcagcg  ctctatcag  tttaacttg  atcctgaat  caagtgcac  4500
gacgacagg  tctgggagg  tctggaaat  gctcagttg  agaatatgg  caaatctct  4560
ccaggaggc  tagacgcca  tgtcaccga  ggtggtgag  acttcagcg  tggacagag  4620
cagctgttc  gcctggcca  ggcctttgt  cgaaagagc  gcatactca  tatggatga  4680
gccacggcc  ccatcgaca  ggccacgga  aacattttg  agaaagtag  catgacagc  4740
tttgcggat  gcacggttg  aaccatagc  catcgggtt  acaccattc  gactgctga  4800
ctggtcatt  tgatgaaga  aggaaacat  ttggaatac  acaccccgg  aagcctctt  4860
gcccaggag  atggagtgt  cgcctcgtt  gttcgtgcg  acatgtgac  ggattacat  4920
acaacagca  ctgtgtctc  atgcctacc  tcgcccacc  gagggttcc  ccaactttg  4980
ctcggaagg  tggcgccgg  aacttcgac  gacttctgt  tggaaagta  agatttctg  5040
ttcctgttt  ggtctgagg  acactccct  taggttcat  gtgggtgtt  tactgtgat  5100
aggccacac  ggaaaggta  cctatgcta  aacatgcca  cgaccttaa  gggtaaatc  5160
gtcgatgtc  gtcaagcac  ggagctgaa  tgaggcgtc  gcgctacca  actctcatt  5220
ggaagacta  cactgccct  ctgttgatg  agaaaattc  ttttctaac  aaatactca  5280
gttcatgat  cataggaga  tcttttctg  gcatttaac  ttgttgata  ttcctttta  5340
cttttcccc  tttaactca  ttcctgtca  cacgaagct  tcatattta  tacctctat  5400
aagccgacc  ctcacaaga  aaagatcat  aaaagagat  gaatatttg  aaatattat  5460
tgtttccat  tgcctccat  caataagga  gaagttcaa  ttagcttca  tccttcagc  5520
atgggccac  taaactaag  tttctagag  ttaattctt  atcagccaa  caatggctc  5580
gaaccctga  atgctatat  atctagggc  caaaagaat  tagatgaat  gccttatct  5640
tcacacaca  acacacaca  acacacaca  acacacaca  acacacaca  atatacata  5700
acatcttca  gccatatct  ggctgtatg  taatcttgg  atgtgcaca  tcctcgaag  5760
taccagata  cccctaccc  acatctctg  gggaagata  aaatagttc  cactctgaa  5820
ttacacagg  agcaagtgt  tattttcac  tgggcaaat  tcagtggca  acattgatg  5880
cacacatgt  gccattggt  ctgttctaa  ttatagagt  taccagaag  ctatatgat  5940
ttagtgtca  atttcattt  avtgcccat  aataaagcc  aactgactg  agttcactt  6000
cctgttatc  agcttccac  gtttctgta  cctttaacc  tcagatata  gcagctgct  6060
aattccata  gagggtctc  acagaaaat  gatgtccat  gcccaccgt  cctgtagtc  6120
tatggcgtt  tttattctg  gtcaagact  atagttctt  tgcatcgag  tatttcaag  6180
tgcctttat  gatatagaa  gtaatgtaa  aaaaacgtt  atagagata  acagaaacg  6240
cccaggtta  ttagcctaa  tagtcacct  ttcttccat  tcaaaaact  cattagaaa  6300
aaataatag  attatttgc  gaaagctag  aggtcacag  tattagcaa  gagttcaac  6360
gcaaaagta  ttcataaga  aatcgacta  tctactaaa  tattgctgg  gctgcagaa  6420
gttctgctg  ggctgatac  catgacgtt  gttgtcagt  agtgtctcc  tctctccta  6480
aaatggcat  catctacag  agtagctcc  tgctgctgt  gcccactac  ccatcctgt  6540
caaaagtga  tttcgtttc  tcgaaactt  tacttactt  atttgcaaa  aacaaacaa  6600
aaacaaaca  acaaacaaa  aaaaaaaa  6628



<210> 536
<211> 1545
<212> PRT
<213> Rattus norvegicus
<308> Q63563
<400> 536

Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Tyr 
  1               5                  10                  15
His Gly Val Leu Gln Asn Pro Cys Phe Val Asp Ala Leu Asn Leu Val 
             20                  25                  30
Pro His Val Phe Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe Ile Gly 
         35                  40                  45
Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Thr Trp Leu 
     50                  55                  60
His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Thr Phe Ala Leu Leu 
 65                  70                  75                  80
Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Gln 
                 85                  90                  95
Arg Ala Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe 
             100                105                110
Val Ala Thr Thr Thr Ser Ile Val Tyr Tyr His Asn Ile Glu Thr Ser 
         115                120                125
Asn Phe Pro Lys Leu Leu Leu Ala Leu Phe Leu Tyr Trp Val Met Ala 
     130                135                140
Phe Ile Thr Lys Thr Ile Lys Leu Val Lys Tyr Trp Gln Leu Gly Trp 
 145                150                155                160
Gly Met Ser Asp Leu Arg Phe Cys Ile Thr Gly Val Met Val Ile Leu 
                 165                170                175
Asn Gly Leu Leu Met Ala Val Glu Ile Asn Val Ile Arg Val Arg Arg 
             180                185                190
Tyr Val Phe Phe Met Asn Pro Gln Lys Val Lys Pro Pro Glu Asp Leu 
         195                200                205
Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu Leu Ser 
     210                215                220
Lys Ala Thr Tyr Trp Trp Met Asn Thr Leu Ile Ile Ser Ala His Arg 
 225                230                235                240
Lys Pro Ile Asp Leu Lys Ala Ile Gly Lys Leu Pro Ile Ala Met Arg 
                 245                250                255
Ala Val Thr Asn Tyr Val Cys Leu Lys Glu Ala Tyr Glu Glu Gln Lys 
             260                265                270
Lys Lys Ala Ala Asp His Pro Asn Arg Thr Pro Ser Ile Trp Leu Ala 
         275                280                285
Met Tyr Arg Ala Phe Gly Arg Pro Ile Leu Leu Ser Ser Thr Phe Arg 
     290                295                300
Tyr Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile Ser Gly 
 305                310                315                320
Ile Val Gln Arg Val Asn Glu Pro Lys Asn Asn Thr Thr Arg Phe Ser 
                 325                330                335
Glu Thr Leu Ser Ser Lys Glu Phe Leu Glu Asn Ala His Val Leu Ala 
             340                345                350
Val Leu Leu Phe Leu Ala Leu Ile Leu Gln Arg Thr Phe Leu Gln Ala 
         355                360                365
Ser Tyr Tyr Val Thr Ile Glu Thr Gly Ile Asn Leu Arg Gly Ala Leu 
     370                375                380
Leu Ala Met Ile Tyr Asn Lys Ile Leu Arg Leu Ser Thr Ser Asn Leu 
 385                390                395                400
Ser Met Gly Glu Met Thr Leu Gly Gln Ile Asn Asn Leu Val Ala Ile 
                 405                410                415
Glu Thr Asn Gln Leu Met Trp Phe Leu Phe Leu Cys Pro Asn Leu Trp 
             420                425                430
Ala Met Pro Val Gln Ile Ile Met Gly Val Ile Leu Leu Tyr Asn Leu 
         435                440                445
Leu Gly Ser Ser Ala Leu Val Gly Ala Ala Val Ile Val Leu Leu Ala 
     450                455                460
Pro Ile Gln Tyr Phe Ile Ala Thr Lys Leu Ala Glu Ala Gln Lys Ser 
 465                470                475                480
Thr Leu Asp Tyr Ser Thr Glu Arg Leu Lys Lys Thr Asn Glu Ile Leu 
                 485                490                495
Lys Gly Ile Lys Leu Leu Lys Leu Tyr Ala Trp Glu His Ile Phe Cys 
             500                505                510
Lys Ser Val Glu Glu Thr Arg Met Lys Glu Leu Ser Ser Leu Lys Thr 
         515                520                525
Phe Ala Leu Tyr Thr Ser Leu Ser Ile Phe Met Asn Ala Ala Ile Pro 
     530                535                540
Ile Ala Ala Val Leu Ala Thr Phe Val Thr His Ala Tyr Ala Ser Gly 
 545                550                555                560
Asn Asn Leu Lys Pro Ala Glu Ala Phe Ala Ser Leu Ser Leu Phe His 
                 565                570                575
Ile Leu Val Thr Pro Leu Phe Leu Leu Ser Thr Val Val Arg Phe Ala 
             580                585                590
Val Lys Ala Ile Ile Ser Val Gln Lys Leu Asn Glu Phe Leu Leu Ser 
         595                600                605
Asp Glu Ile Gly Glu Asp Ser Trp Arg Thr Gly Glu Gly Thr Leu Pro 
     610                615                620
Phe Glu Ser Cys Lys Lys His Thr Gly Val Gln Ser Lys Pro Ile Asn 
 625                630                635                640
Arg Lys Gln Pro Gly Arg Tyr His Leu Asp Asn Tyr Glu Gln Ala Arg 
                 645                650                655
Arg Leu Arg Pro Ala Glu Thr Glu Asp Val Ala Ile Lys Val Thr Asn 
             660                665                670
Gly Tyr Phe Ser Trp Gly Ser Gly Leu Ala Thr Leu Ser Asn Ile Asp 
         675                680                685
Ile Arg Ile Pro Thr Gly Gln Leu Thr Met Ile Val Gly Gln Val Gly 
     690                695                700
Cys Gly Lys Ser Ser Leu Leu Leu Ala Ile Leu Gly Glu Met Gln Thr 
 705                710                715                720
Leu Glu Gly Lys Val Tyr Trp Asn Asn Val Asn Glu Ser Glu Pro Ser 
                 725                730                735
Phe Glu Ala Thr Arg Ser Arg Ser Arg Tyr Ser Val Ala Tyr Ala Ala 
             740                745                750
Gln Lys Pro Trp Leu Leu Asn Ala Thr Val Glu Glu Asn Ile Thr Phe 
         755                760                765
Gly Ser Ser Phe Asn Arg Gln Arg Tyr Lys Ala Val Thr Asp Ala Cys 
     770                775                780
Ser Leu Gln Pro Asp Ile Asp Leu Leu Pro Phe Gly Asp Gln Thr Glu 
 785                790                795                800
Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly Gln Arg Gln Arg Ile 
                 805                810                815
Cys Val Ala Arg Ala Leu Tyr Gln Asn Thr Asn Ile Val Phe Leu Asp 
             820                825                830
Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser Asp His Leu Met Gln 
         835                840                845
Glu Gly Ile Leu Lys Phe Leu Gln Asp Asp Lys Arg Thr Val Val Leu 
     850                855                860
Val Thr His Lys Leu Gln Tyr Leu Thr His Ala Asp Trp Ile Ile Ala 
 865                870                875                880
Met Lys Asp Gly Ser Val Leu Arg Glu Gly Thr Leu Lys Asp Ile Gln 
                 885                890                895
Thr Lys Asp Val Glu Leu Tyr Glu His Trp Lys Thr Leu Met Asn Arg 
             900                905                910
Gln Asp Gln Glu Leu Glu Lys Asp Met Glu Ala Asp Gln Thr Thr Leu 
         915                920                925
Glu Arg Lys Thr Leu Arg Arg Ala Met Tyr Ser Arg Glu Ala Lys Ala 
     930                935                940
Gln Met Glu Asp Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp 
 945                950                955                960
Asp Asn Met Ser Thr Val Met Arg Leu Arg Thr Lys Met Pro Trp Lys 
                 965                970                975
Thr Cys Trp Trp Tyr Leu Thr Ser Gly Gly Phe Phe Leu Leu Phe Leu 
             980                985                990
Met Ile Phe Ser Lys Leu Leu Lys His Ser Val Ile Val Ala Ile Asp 
         995                1000                1005
Tyr Trp Leu Ala Thr Trp Thr Ser Glu Tyr Ser Ile Asn Asp Pro Gly 
     1010                1015                1020
Lys Ala Asp Gln Thr Phe Tyr Val Ala Gly Phe Ser Ile Leu Cys Gly 
 1025                1030                1035                1040
Ala Gly Ile Phe Leu Cys Leu Val Thr Ser Leu Thr Val Glu Trp Met 
                 1045                1050                1055
Gly Leu Thr Ala Ala Lys Asn Leu His His Asn Leu Leu Asn Lys Ile 
             1060                1065                1070
Ile Leu Gly Pro Ile Arg Phe Phe Asp Thr Thr Pro Leu Gly Leu Ile 
         1075                1080                1085
Leu Asn Arg Phe Ser Ala Asp Thr Asn Ile Ile Asp Gln His Ile Pro 
     1090                1095                1100
Pro Thr Leu Glu Ser Leu Thr Arg Ser Thr Leu Leu Cys Leu Ser Ala 
 1105                1110                1115                1120
Ile Gly Met Ile Ser Tyr Ala Thr Pro Val Phe Leu Ile Ala Leu Ala 
                 1125                1130                1135
Pro Leu Gly Val Ala Phe Tyr Phe Ile Gln Lys Tyr Phe Arg Val Ala 
             1140                1145                1150
Ser Lys Asp Leu Gln Glu Leu Asp Asp Ser Thr Gln Leu Pro Leu Leu 
         1155                1160                1165
Cys His Phe Ser Glu Thr Ala Glu Gly Leu Thr Thr Ile Arg Ala Phe 
     1170                1175                1180
Arg His Glu Thr Arg Phe Lys Gln Arg Met Leu Glu Leu Thr Asp Thr 
 1185                1190                1195                1200
Asn Asn Ile Ala Tyr Leu Phe Leu Ser Ala Ala Asn Arg Trp Leu Glu 
                 1205                1210                1215
Val Arg Thr Asp Tyr Leu Gly Ala Cys Ile Val Leu Thr Ala Ser Ile 
             1220                1225                1230
Ala Ser Ile Ser Gly Ser Ser Asn Ser Gly Leu Val Gly Leu Gly Leu 
         1235                1240                1245
Leu Tyr Ala Leu Thr Ile Thr Asn Tyr Leu Asn Trp Val Val Arg Asn 
     1250                1255                1260
Leu Ala Asp Leu Glu Val Gln Met Gly Ala Val Lys Lys Val Asn Ser 
 1265                1270                1275                1280
Phe Leu Thr Met Glu Ser Glu Asn Tyr Glu Gly Thr Met Asp Pro Ser 
                 1285                1290                1295
Gln Val Pro Glu His Trp Pro Gln Glu Gly Glu Ile Lys Ile His Asp 
             1300                1305                1310
Leu Cys Val Arg Tyr Glu Asn Asn Leu Lys Pro Val Leu Lys His Val 
         1315                1320                1325
Lys Ala Tyr Ile Lys Pro Gly Gln Lys Val Gly Ile Cys Gly Arg Thr 
     1330                1335                1340
Gly Ser Gly Lys Ser Ser Leu Ser Leu Ala Phe Phe Arg Met Val Asp 
 1345                1350                1355                1360
Ile Phe Asp Gly Lys Ile Val Ile Asp Gly Ile Asp Ile Ser Lys Leu 
                 1365                1370                1375
Pro Leu His Thr Leu Arg Ser Arg Leu Ser Ile Ile Leu Gln Asp Pro 
             1380                1385                1390
Ile Leu Phe Ser Gly Ser Ile Arg Phe Asn Leu Asp Pro Glu Cys Lys 
         1395                1400                1405
Cys Thr Asp Asp Arg Leu Trp Glu Ala Leu Glu Ile Ala Gln Leu Lys 
     1410                1415                1420
Asn Met Val Lys Ser Leu Pro Gly Gly Leu Asp Ala Thr Val Thr Glu 
 1425                1430                1435                1440
Gly Gly Glu Asn Phe Ser Val Gly Gln Arg Gln Leu Phe Cys Leu Ala 
                 1445                1450                1455
Arg Ala Phe Val Arg Lys Ser Ser Ile Leu Ile Met Asp Glu Ala Thr 
             1460                1465                1470
Ala Ser Ile Asp Met Ala Thr Glu Asn Ile Leu Gln Lys Val Val Met 
         1475                1480                1485
Thr Ala Phe Ala Asp Arg Thr Val Val Thr Ile Ala His Arg Val Ser 
     1490                1495                1500
Ser Ile Met Asp Ala Gly Leu Val Leu Val Phe Ser Glu Gly Ile Leu 
 1505                1510                1515                1520
Val Glu Cys Asp Thr Gly Pro Asn Leu Leu Gln His Lys Asn Gly Leu 
                 1525                1530                1535
Phe Ser Thr Leu Val Met Thr Asn Lys 
             1540                1545



<210> 537
<211> 3170
<212> DNA
<213> Homo sapiens
<308> AK056519
<400> 537

gtgcttcgc  taggggagg  aaactgtca  cggagagtt  tgcgtccgg  tttgaaatt  60
acatcttaa  acagtgtag  aagtcggtg  tttgaaggt  gctcaagtg  accggcagg  120
gtttgaagc  gcgtgaagc  attgcccaa  agtaaacca  ataagaaga  atgagcctt  180
cattttgtg  taacaacat  tcttcatat  atatcaacg  tggtgtact  caaaattcc  240
gctttgtgg  tgccctcaa  ctggtccct  atgtctttc  gttgtttat  acttttcca  300
tattgttta  tgggtgggg  agccaaagc  caaaagtac  aattcacca  aacacatgg  360
ttcattttc  gggacataa  ctgagatgg  ttcttacat  cgctctcct  tttgtgcat  420
tctgtgaaa  agcagaagg  attgtttca  actcgcggc  ggaatcaag  cacctccac  480
tctttatgc  agccgtgat  ggattcgtt  ccactacaa  atcgatagt  tattatcat  540
atatcgaaa  atcaaattt  cctaaatta  ttttagttc  aggtgtttc  gtctctggc  600
tggagtcca  ggacatttt  ccaaggttc  agcctttca  tgatgctgt  ggaatgcca  660
attttacta  aattactat  tagcagagt  tgtttctag  ataatgaaa  gtatgctgt  720
ctgaggagc  gctgccatt  catcacggc  tttcgcacc  gcattgtga  taaaattgt  780
ttattagcc  ctcttgctt  cttgttctg  ggaaatcag  ggctctcta  aatattcct  840
attttattt  tgccttggg  caaaattat  taacgcatc  atatgagtt  tgttcaata  900
tctgaccca  cactgtatt  cttggagta  actttcttt  ttaaagaga  aaaggtatg  960
aacaagaat  acagatggg  tatgaacct  ctgaaattg  agttcgaat  atgtgtttg  1020
gtgaatgat  cttactgtt  ctgatttta  ttgattgtt  tataatgaa  atgatgttg  1080
ctaatgata  agaaattag  agaagaaat  ttgaaaaca  acacacagt  ttttattca  1140
ttgtccaga  gacatgaaa  tttaaaatg  atgcatgaa  gatattgat  atttaatta  1200
atgttgtgt  acattatat  attgttaaa  gcaatctaa  aaaaaaggt  gagagggtt  1260
aatattaat  taaaaggct  tcacatttt  aattatctt  atagaaagg  cttttgtgc  1320
aaatgagag  cagacatta  tgcagaaaa  gccaaaaaa  gagaaagaa  tttccaaca  1380
gtagctgca  aaaaatatg  gaaattgag  atttaataa  ctaaatatc  atttttgaa  1440
agttgatgg  aaaaagaaa  gttataact  gaaaggaat  tagatatta  taatgtttt  1500
atggaaatg  aatcagaag  ggcctatta  tgttattta  gtgcaagac  gcacaattt  1560
atcatattg  tggaaggac  tggagataa  atataatat  tcttgttat  ttaacagag  1620
aaaatttgg  cctaggaaa  ttactcatt  taagaccac  aagatagta  ttttgtctc  1680
acatttcat  atgaaaatc  ccaaatgta  agaaagttg  aagaatcat  tgaattccc  1740
cttacccaa  atctgaatt  ttcaaatta  attttttct  tttgtttta  cacatatct  1800
catcttttc  tccttctat  catacctct  tccatctta  ttttgatgc  ttttaaggt  1860
agttgtaga  attagtata  tttacctct  aacgcttca  gcgtatctt  ttgtgagac  1920
aaatttata  acatgaaac  cagcgatct  aatttgcta  atgcatgta  ctatataac  1980
ctatcatga  ataactatc  tccatgcaa  ttttcttat  ctcaatttc  cctttacag  2040
agcaatatc  gttctgatt  ttaccccca  catggatta  gtttgcctg  tctagaact  2100
catgtaaat  gaatgacac  gtatagact  ttaagtaag  cttcttttt  taagcatga  2160
tttttgatg  tcatccgta  tgtagcata  atcaatatt  tcttattgt  gcatttcat  2220
gtataacta  atcatagtt  tttcaatcc  ttgttaata  acatctgta  tatttccag  2280
ttttagcca  catgagagt  aaagctgct  tcaacattc  taagtattt  gtggctata  2340
gcatttatt  ctcctaggt  aatacctaa  agtgaaatc  ctgggtcat  caataagtg  2400
gtaaatgtt  atattttaa  aaactgaca  cttttccca  aatgtttgt  tcatttttt  2460
tactcacta  caaggtgta  gagttccag  tccacatgt  catcatttg  tgatcttgg  2520
ctaatttag  catgctagt  ggtgtgtac  ggtaataca  tgcggtttt  atttgcatt  2580
atctgattg  taattatgt  gaacactct  tgatgagtt  attggccat  tttaatctt  2640
gggatgtgg  tattcatat  ttttgccca  gtttcattg  gttgcactt  tattattgc  2700
ttgtaggaa  attttgtgc  tactagata  tagtatgtc  tcagttaca  gttttgata  2760
tgttttcct  ctagtctgt  gcatacata  tcatttatt  aatagggtc  tttaatgag  2820
agaagattt  aaatttcga  gtagtataa  ttatcattt  ttctagtcc  tagttactg  2880
tttctgtgt  ttaagacat  tttgtcttc  ctctaaata  gtttccctc  tattctcct  2940
tttgctttt  gatgcttta  ggtttccat  tttattttt  ggactacga  tctttctaa  3000
ttaattgtg  atatggtgt  agataggtg  caaagttct  ttttttttt  tttttttcc  3060
agtggatat  aatgtgttc  agcaccatt  gtgggatag  ctttctgtt  ctcaagaga  3120
tgcattggc  cttatgtaa  aaaaaataa  tcaaatgac  atttaaattt  3170



<210> 538
<211> 411
<212> DNA
<213> Rattus norvegicus
<308> AF020210
<400> 538

cttcttccc  gagggactg  tgtggtcac  cggagacct  ttattctgc  gctggtcca  60
gtttcacca  aagataaaa  aaaaacaac  ggagaagaa  atggtaaat  tcagagctg  120
aaccctgct  catggaaaa  ctcaagaca  ctttctaaa  gagttgaag  agaagaatg  180
ggtaaattt  ttcacacca  aaacaagct  tacacagat  ttgatgaaa  tcgacaaga  240
attgaaaat  aaactgaaa  aatttcagg  aataataag  gagtaagcc  tgagccaat  300
catctcaag  ttttctcgc  caacgttgt  aacctgacg  ttgtggatt  accaggaat  360
accaaagta  ctgtaggtg  tcagcccaa  gatattgag  ttcaaatca  a  411



<210> 539
<211> 137
<212> PRT
<213> Rattus norvegicus
<308> AAB71235
<400> 539

Leu Leu Pro Arg Gly Thr Gly Val Val Thr Arg Arg Pro Leu Ile Leu 
  1               5                  10                  15
Gln Leu Val His Val Ser Pro Glu Asp Lys Arg Lys Thr Thr Gly Glu 
             20                  25                  30
Glu Asn Gly Lys Phe Gln Ser Trp Asn Pro Ala Thr Trp Lys Asn Ser 
         35                  40                  45
Arg His Leu Ser Lys Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu 
     50                  55                  60
His Thr Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu 
 65                  70                  75                  80
Ile Glu Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser 
                 85                  90                  95
Pro Glu Pro Ile His Leu Lys Val Phe Ser Pro Asn Val Val Asn Leu 
             100                105                110
Thr Leu Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln 
         115                120                125
Pro Lys Asp Ile Glu Leu Gln Ile Arg 
     130                135



<210> 540
<211> 411
<212> DNA
<213> Rattus norvegicus
<308> AF020210
<400> 540

cttcttccc  gagggactg  tgtggtcac  cggagacct  ttattctgc  gctggtcca  60
gtttcacca  aagataaaa  aaaaacaac  ggagaagaa  atggtaaat  tcagagctg  120
aaccctgct  catggaaaa  ctcaagaca  ctttctaaa  gagttgaag  agaagaatg  180
ggtaaattt  ttcacacca  aaacaagct  tacacagat  ttgatgaaa  tcgacaaga  240
attgaaaat  aaactgaaa  aatttcagg  aataataag  gagtaagcc  tgagccaat  300
catctcaag  ttttctcgc  caacgttgt  aacctgacg  ttgtggatt  accaggaat  360
accaaagta  ctgtaggtg  tcagcccaa  gatattgag  ttcaaatca  a  411



<210> 541
<211> 137
<212> PRT
<213> Rattus norvegicus
<308> AAB71235
<400> 541

Leu Leu Pro Arg Gly Thr Gly Val Val Thr Arg Arg Pro Leu Ile Leu 
  1               5                  10                  15
Gln Leu Val His Val Ser Pro Glu Asp Lys Arg Lys Thr Thr Gly Glu 
             20                  25                  30
Glu Asn Gly Lys Phe Gln Ser Trp Asn Pro Ala Thr Trp Lys Asn Ser 
         35                  40                  45
Arg His Leu Ser Lys Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu 
     50                  55                  60
His Thr Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu 
 65                  70                  75                  80
Ile Glu Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser 
                 85                  90                  95
Pro Glu Pro Ile His Leu Lys Val Phe Ser Pro Asn Val Val Asn Leu 
             100                105                110
Thr Leu Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln 
         115                120                125
Pro Lys Asp Ile Glu Leu Gln Ile Arg 
     130                135



<210> 542
<211> 636
<212> DNA
<213> Rattus norvegicus
<308> AF020212
<400> 542

atggtacat  acttagtgg  aattgagct  gcatatatc  acacaaaac  ccccgactt  60
gctgatgtc  gtgggctaa  gaacaataa  atagaggaa  aaagaagaa  cagactagc  120
agagaacta  cttcagctg  atcgcgaga  aagtcttct  aagttccaa  tgctttggc  180
cctgcctcc  aggagccct  ccctgccgc  tctgccgag  ctgatggca  ggttgcatc  240
gcaggtggt  gaattggag  tggtggtcg  attggagat  gtggtcagg  accgacaac  300
ggcaactgg  gaggaatgc  gaaaacttc  aaagctgaa  aattacttg  tgaagaaaa  360
tcaaaacca  ttccaatta  gccagcaag  ccacaaaaa  gccatgctg  caatttgct  420
gatgtgcca  ttccagttg  acgaaaact  tctgcccga  aacagcgag  ttgtgaggt  480
attgaaaga  tcatcaaat  atattttct  attgtcaga  agaatattc  agacagcgt  540
ccaaaggca  taatgcatt  tttggttaa  catgtgaaa  atactcttc  gagtgaatt  600
gtagggcag  tgtataagt  atccttatt  gatgac  636



<210> 543
<211> 212
<212> PRT
<213> Rattus norvegicus
<308> AAB71237
<400> 543

Met Val His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr Lys 
  1               5                  10                  15
His Pro Asp Phe Ala Asp Val Cys Gly Leu Met Asn Asn Asn Ile Glu 
             20                  25                  30
Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val Ser 
         35                  40                  45
Arg Asp Lys Ser Ser Lys Val Pro Ser Ala Leu Ala Pro Ala Ser Gln 
     50                  55                  60
Glu Pro Ser Pro Ala Ala Ser Ala Glu Ala Asp Gly Lys Val Ala Ser 
 65                  70                  75                  80
Ala Gly Gly Gly Ile Gly Asp Gly Gly Arg Ile Gly Asp Gly Gly Gln 
                 85                  90                  95
Glu Pro Thr Thr Gly Asn Trp Arg Gly Met Leu Lys Thr Ser Lys Ala 
             100                105                110
Glu Glu Leu Leu Ala Glu Glu Lys Ser Lys Pro Ile Pro Ile Met Pro 
         115                120                125
Ala Ser Pro Gln Lys Gly His Ala Val Asn Leu Leu Asp Val Pro Val 
     130                135                140
Pro Val Ala Arg Lys Leu Ser Ala Arg Glu Gln Arg Asp Cys Glu Val 
 145                150                155                160
Ile Glu Arg Leu Ile Lys Ser Tyr Phe Leu Ile Val Arg Lys Asn Ile 
                 165                170                175
Gln Asp Ser Val Pro Lys Ala Val Met His Phe Leu Val Asn His Val 
             180                185                190
Lys Asp Thr Leu Gln Ser Glu Leu Val Gly Gln Leu Tyr Lys Ser Ser 
         195                200                205
Leu Leu Asp Asp 
     210



<210> 544
<211> 3293
<212> DNA
<213> Homo sapiens
<308> NM_012062
<400> 544

ggaggcgaa  tgtgggccc  ggccattca  tgccgtggc  ggcgggcac  ggggccccg  60
gttttcaga  tcatggagg  gctaattcc  gtcataaac  agctccagg  cgtcttcaa  120
acggtgggc  ccgacatca  ccagctgcc  caaatcgtc  tagtgggaa  gcagagcag  180
ggaaagagc  cagtgctag  aagcctggt  gggagggac  tgcttccca  aggtactgg  240
attgtcacc  ggagacctc  cattctgca  ctggtccat  tgacacaag  agataaacg  300
aaaacaaca  gagaagaaa  tggggtgga  gcagaagaa  ggggtaaat  tcttcacac  360
aaaaataag  tttacacgg  ttttgatga  attcgacaa  aaattgaaa  tgaaacaga  420
agaatttca  gaaataata  gggagtaag  cctgaacca  ttcatctta  gattttttc  480
cccaacgtt  tcaatttga  acttgtgga  ttgccagga  tgaccaagg  gcctgtagg  540
gatcaacct  aggatattg  gcttcaaat  agagagctc  ttcttcggt  catcagtaa  600
cctaattcc  ttatcctcg  tgtcactgc  gctaataca  atatggcaa  atcagaggc  660
cttaaaatt  caagagagg  agatccaga  ggtcgcaga  ccctagctg  aatcactaa  720
cttgatctc  tggatgcgg  tactgatgc  atggatgta  tgatgggaa  ggttattcc  780
gtcaaactt  gaataattg  agtagttaa  aggagccag  tagatatta  caacaagaa  840
agtgtaact  attcaatcc  tgatgagta  gcttttctt  aaaagaaat  tccatctct  900
gccaataga  atggaacaa  gtatcttgc  aggactcta  acaggttac  gatgcatca  960
atcagagat  gtttaccag  gttgaaaac  agaataaat  ttctagctg  tcagtatca  1020
tctcttcta  atagctacg  tgaacccgt  gatgataaa  gtgctactt  actccaact  1080
attaccaaa  ttgccacag  atattgtaa  actattgaa  gaactgcaa  atatattga  1140
acttcggag  tatgcggtg  tgctagaat  tgttatatt  tccatgaga  ttttgggcg  1200
accttagaa  ctgttgatc  acttggtgg  cttaacact  ttgacattt  gactgccat  1260
agaaatgct  ctggtcctc  tcctgcttt  tttgtgcct  aggtttcat  tgagttact  1320
gtgaagcgg  aaatcaaac  tctagaaga  cccagcctc  gctgtgtgg  actggttca  1380
gaggaaatg  aaaggatca  tcagcactg  agcaattac  gtacacagg  attgttacg  1440
tttcctaaa  ttcatgatg  catagttga  gtggtgact  gtcttcttc  taaaaggtt  1500
cctgttaca  atgaaatgg  ccataactt  gtggcaatt  aactggctt  tatcaacac  1560
aaacatcca  actttgctg  tgcttgtgg  ctaatgaac  ataatatag  ggaacaaag  1620
agaaacagg  tagccagag  attaccttc  gctgtatca  gagacaagt  ttctaaagt  1680
ccaagtgct  tggcacctg  ctcccagga  ccctccccc  ctgcttctg  tgaggctga  1740
ggcaagtta  ttcaggaca  cagaagaga  actaaaaat  ttgcatctg  aggtggtgg  1800
gttggagat  gtgttcaag  accaaccac  ggcaactgg  gaggaatgc  gaaaacttc  1860
aaagctgaa  agttattag  agaagaaaa  tcaaaaccc  ttccaatta  gccagccag  1920
ccacaaaaa  gtcatgccg  gaacctgct  gatgtgcca  ttcctgttg  acgaaaact  1980
tctgctcgg  aacagcgag  ttgtgaggt  attgaacga  tcattaaat  atattttct  2040
attgtcaga  agaatattc  agacagtgt  ccaaaggca  taatgcatt  tttggttaa  2100
catgtgaaa  acactcttc  gagtgagct  gtaggccag  tgtataaat  atccttatt  2160
gatgatctt  tgacagaat  tgaggacat  gcacagcgc  ggaaagaag  agctgatat  2220
ctaaaggca  tacaaggag  cagtcaaat  attgctgaa  tccgggaga  tcatctttg  2280
tgaagagaa  tatgtaata  tgagacttt  ttgactcaa  acttgctag  tactgccta  2340
ctgagtaga  tcttattta  gaactcctg  gtattgcaa  ggtatgaat  tgctcatgt  2400
gagactggc  ataaactga  aagtgtatt  caaattgca  aacacatca  acatttaat  2460
caaataata  atggctgtt  ctaaagttt  ccagtatat  taaaataca  caagtctgt  2520
ttgtgacag  ttcatctga  cttaactta  aaacaactg  taatgttct  gttgtgcaa  2580
gcagtttgc  tgtggataa  atgacctgt  taataatct  tgttagtag  cttaaagct  2640
ctgccatag  cctccaaga  gaaagcacc  agacaacat  tcatatgac  ataatgcat  2700
tactatata  gctgatctg  ctttgaaag  tgtgagttg  caagttcct  acatagagt  2760
attgtattc  acctgtcct  caatttagt  ttttctgag  ttctttgca  cctttgatg  2820
gtttttaag  aagctgaat  cacaagagg  tctgtgaca  tgacatggc  gtggtgtgc  2880
tactgtgta  ttacatagc  cttccaatt  tgggtccat  tgcactagc  aattaaaat  2940
tgctttgat  catacttaa  cctgaaagc  ggaatgcct  cattaattc  tacattaaa  3000
acagccatc  acccttgat  atctagaaa  acttggtaa  gatggtcag  tccttttag  3060
tttcagaaa  tcaaatgat  acctaaatt  cccttaatt  gcaaataca  tagtaatta  3120
ggtacatct  taaagtgga  cacttacac  aggctctaa  attcacttt  aggtggaac  3180
taaaaccag  gtactgtat  tatgcattg  taatagcta  ttttgcttc  tagcttcat  3240
ccaacaaaa  atatttatt  gaatagtat  aaagtactg  aggagttga  aga  3293



<210> 545
<211> 736
<212> PRT
<213> Homo sapiens
<308> NP_036192
<400> 545

Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn 
  1               5                  10                  15
Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly 
             20                  25                  30
Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg 
         35                  40                  45
Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile 
     50                  55                  60
Leu Gln Leu Val His Val Thr Gln Glu Asp Lys Arg Lys Thr Thr Gly 
 65                  70                  75                  80
Glu Glu Asn Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr 
                 85                  90                  95
Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu 
             100                105                110
Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu 
         115                120                125
Pro Ile His Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu 
     130                135                140
Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys 
 145                150                155                160
Asp Ile Glu Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn 
                 165                170                175
Pro Asn Ser Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala 
             180                185                190
Thr Ser Glu Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg 
         195                200                205
Arg Thr Leu Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr 
     210                215                220
Asp Ala Met Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly 
 225                230                235                240
Ile Ile Gly Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys 
                 245                250                255
Ser Val Thr Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys 
             260                265                270
Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr 
         275                280                285
Leu Asn Arg Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu 
     290                295                300
Lys Thr Arg Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn 
 305                310                315                320
Ser Tyr Gly Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu 
                 325                330                335
Ile Thr Lys Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala 
             340                345                350
Lys Tyr Ile Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr 
         355                360                365
Ile Phe His Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu 
     370                375                380
Gly Gly Leu Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr 
 385                390                395                400
Gly Pro Arg Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu 
                 405                410                415
Val Lys Arg Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val 
             420                425                430
Glu Leu Val His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn 
         435                440                445
Tyr Ser Thr Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile 
     450                455                460
Val Glu Val Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn 
 465                470                475                480
Glu Met Val His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr 
                 485                490                495
Lys His Pro Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile 
             500                505                510
Glu Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val 
         515                520                525
Ser Arg Asp Lys Ser Ser Lys Val Pro Ser Ala Leu Ala Pro Ala Ser 
     530                535                540
Gln Glu Pro Ser Pro Ala Ala Ser Ala Glu Ala Asp Gly Lys Leu Ile 
 545                550                555                560
Gln Asp Ser Arg Arg Glu Thr Lys Asn Val Ala Ser Gly Gly Gly Gly 
                 565                570                575
Val Gly Asp Gly Val Gln Glu Pro Thr Thr Gly Asn Trp Arg Gly Met 
             580                585                590
Leu Lys Thr Ser Lys Ala Glu Glu Leu Leu Ala Glu Glu Lys Ser Lys 
         595                600                605
Pro Ile Pro Ile Met Pro Ala Ser Pro Gln Lys Gly His Ala Val Asn 
     610                615                620
Leu Leu Asp Val Pro Val Pro Val Ala Arg Lys Leu Ser Ala Arg Glu 
 625                630                635                640
Gln Arg Asp Cys Glu Val Ile Glu Arg Leu Ile Lys Ser Tyr Phe Leu 
                 645                650                655
Ile Val Arg Lys Asn Ile Gln Asp Ser Val Pro Lys Ala Val Met His 
             660                665                670
Phe Leu Val Asn His Val Lys Asp Thr Leu Gln Ser Glu Leu Val Gly 
         675                680                685
Gln Leu Tyr Lys Ser Ser Leu Leu Asp Asp Leu Leu Thr Glu Ser Glu 
     690                695                700
Asp Met Ala Gln Arg Arg Lys Glu Ala Ala Asp Met Leu Lys Ala Leu 
 705                710                715                720
Gln Gly Ala Ser Gln Ile Ile Ala Glu Ile Arg Glu Thr His Leu Trp 
                 725                730                735



<210> 546
<211> 2225
<212> DNA
<213> Rattus norvegicus
<308> AF020618
<400> 546

ctgcagtac  tgtacattg  taaataaag  gagggactc  aggaggagc  gcctgggtc  60
aagaggtag  cagaaggag  ttttagggg  ctgagcaca  gcttgagga  agaaaggtt  120
ttaaaaagc  agacgctta  aggtctcag  agggctagc  agaaactgt  gctggggtt  180
aggaaaggg  ttaagagtg  gggcttttg  ttctgagga  gtagaacgt  aatgttgag  240
gaagaacca  gtggcggag  tgggtgtga  caatgctat  aggaatttg  ggcagggat  300
cacgcgctg  tgtgactat  ttttaacaa  gactcagtg  tgtgacctg  tactgtttc  360
agagcgact  ctaaacaaa  tcccccttt  taggccaga  acatggccc  aagcccaag  420
ccccagcat  tcctgcact  gaaggaagc  cactctttc  acctcctgt  tccactgat  480
ggcttcctc  gccgggcct  gagccgcct  agggggccc  aggtctcag  ggcctggtt  540
gcagaaaca  tagcaggag  aaaccagat  gaggctgat  ctctgttga  gcctccccc  600
gtctctgaa  atcacctac  tctccgaga  actgaagga  atggaactc  tgaatggag  660
aaagcagcc  agaggctct  ccttgatgt  gaagcccaa  gttcccctc  taaaacttg  720
ggactttca  atattgatg  acataatgg  aagccagga  aagatggcc  tagagagca  780
gaagtggag  acacagctg  cctgcctac  ctacagccc  ttcacctgc  aggggcaga  840
aagaaagtt  gggaggtgg  ggctagaga  gagggtgtg  ccgagctgg  ttaccccac  900
tcacactgg  agggtggtc  agctgagga  gaagaggat  cagaaaccg  gaagaaggc  960
caccaggcc  ctgctgctt  catagctcc  ggatataaa  ccagcactt  tgtgtattg  1020
ccaggggag  cagaacatc  agccacgga  gaaaaagga  cagacaata  ggctgaacc  1080
tcaggctcc  actccagag  ctgggagta  cacactaga  agaggccta  gcaggaggg  1140
gaaactaag  cagagcaac  cagggcagg  cagagtcac  cttgtcaga  tgcagaggc  1200
gaggaagga  gacctgaga  ttctgtctg  tctggcagt  ccttcctga  ggcctgggt  1260
tatcgccca  gagaggaca  agaggagga  gaagacagt  atttggatt  agctgagga  1320
gacacagct  atacctgta  cacccccca  acaagtgcc  tcctgaagg  ctgggtcta  1380
cgcccagga  aggacacag  agaggaaga  gacggtgat  gggattcag  tgaggaaga  1440
gcgtctcag  gctgtacca  cccccatac  agtgccttc  tgaaggcct  ggtctatcg  1500
ccaggagag  acacagaag  ggaagacga  agtgagaat  tggccccag  tgactcaga  1560
acagttgac  cttgccaga  tacccagca  tgtctacca  tagagaaga  caagggatg  1620
ggagaagca  agccccctc  cttccagtg  ccttctatt  acctggaca  aagccagca  1680
caccttggg  tgcccctaa  ctgcccctt  gactgcaga  gcggctcag  tctttcaaa  1740
cccccgccc  gaatcaggg  cctgagatt  ctctgaagg  tagaaaggt  cacttctct  1800
agaaagtta  agtccattt  cttgctgtc  gggcaggac  agcccaggc  gctcgtcga  1860
gcccctggg  gcagtttgc  cgagatcga  gccgctttg  tcgacgcat  gccaggcag  1920
ggagcagct  ggtccttac  ttacccctg  tttcagggc  agagcatgg  cacgcctta  1980
aaacctacc  cttcctctg  cgtcctcgt  tcttccact  cctgagcct  gctcttcca  2040
tgaggccac  cccctcagc  aagatgtga  cactccctc  ccccttccc  gtgaaatcc  2100
tcctcccag  ctggacttg  gaggaaggc  ggctaagcc  gagtagttt  ttgtgtatt  2160
tatgagtgt  agtctctta  tacgaatat  taacgcctt  tgcatttgt  aaaaaaaaa  2220
aaaaa  2225



<210> 547
<211> 457
<212> PRT
<213> Rattus norvegicus
<308> AAC24980
<400> 547

Met Ala Pro Ser Pro Arg Pro Gln His Val Leu His Trp Lys Glu Ala 
  1               5                  10                  15
His Ser Phe Tyr Leu Leu Ser Pro Leu Met Gly Phe Leu Ser Arg Ala 
             20                  25                  30
Trp Ser Arg Leu Arg Gly Pro Glu Val Ser Glu Ala Trp Leu Ala Glu 
         35                  40                  45
Thr Val Ala Gly Ala Asn Gln Ile Glu Ala Asp Ala Leu Leu Thr Pro 
     50                  55                  60
Pro Pro Val Ser Glu Asn His Leu Pro Leu Arg Glu Thr Glu Gly Asn 
 65                  70                  75                  80
Gly Thr Pro Glu Trp Ser Lys Ala Ala Gln Arg Leu Cys Leu Asp Val 
                 85                  90                  95
Glu Ala Gln Ser Ser Pro Pro Lys Thr Trp Gly Leu Ser Asp Ile Asp 
             100                105                110
Glu His Asn Gly Lys Pro Gly Gln Asp Gly Leu Arg Glu Gln Glu Val 
         115                120                125
Glu His Thr Ala Gly Leu Pro Thr Leu Gln Pro Leu His Leu Gln Gly 
     130                135                140
Ala Asp Lys Lys Val Gly Glu Val Val Ala Arg Glu Glu Gly Val Ser 
 145                150                155                160
Glu Leu Ala Tyr Pro Thr Ser His Trp Glu Gly Gly Pro Ala Glu Asp 
                 165                170                175
Glu Glu Asp Thr Glu Thr Val Lys Lys Ala His Gln Ala Ser Ala Ala 
             180                185                190
Ser Ile Ala Pro Gly Tyr Lys Pro Ser Thr Ser Val Tyr Cys Pro Gly 
         195                200                205
Glu Ala Glu His Arg Ala Thr Glu Glu Lys Gly Thr Asp Asn Lys Ala 
     210                215                220
Glu Pro Ser Gly Ser His Ser Arg Val Trp Glu Tyr His Thr Arg Glu 
 225                230                235                240
Arg Pro Lys Gln Glu Gly Glu Thr Lys Pro Glu Gln His Arg Ala Gly 
                 245                250                255
Gln Ser His Pro Cys Gln Asn Ala Glu Ala Glu Glu Gly Gly Pro Glu 
             260                265                270
Thr Ser Val Cys Ser Gly Ser Ala Phe Leu Lys Ala Trp Val Tyr Arg 
         275                280                285
Pro Gly Glu Asp Thr Glu Glu Glu Glu Asp Ser Asp Leu Asp Ser Ala 
     290                295                300
Glu Glu Asp Thr Ala His Thr Cys Thr Thr Pro His Thr Ser Ala Phe 
 305                310                315                320
Leu Lys Ala Trp Val Tyr Arg Pro Gly Glu Asp Thr Glu Glu Glu Asp 
                 325                330                335
Asp Gly Asp Trp Asp Ser Ala Glu Glu Asp Ala Ser Gln Ser Cys Thr 
             340                345                350
Thr Pro His Thr Ser Ala Phe Leu Lys Ala Trp Val Tyr Arg Pro Gly 
         355                360                365
Glu Asp Thr Glu Glu Glu Asp Asp Ser Glu Asn Val Ala Pro Val Asp 
     370                375                380
Ser Glu Thr Val Asp Ser Cys Gln Ser Thr Gln His Cys Leu Pro Val 
 385                390                395                400
Glu Lys Thr Lys Gly Cys Gly Glu Ala Glu Pro Pro Pro Phe Gln Trp 
                 405                410                415
Pro Ser Ile Tyr Leu Asp Arg Ser Gln His His Leu Gly Leu Pro Leu 
             420                425                430
Ser Cys Pro Phe Asp Cys Arg Ser Gly Ser Asp Leu Ser Lys Pro Pro 
         435                440                445
Pro Gly Ile Arg Ala Leu Arg Phe Leu 
     450                455



<210> 548
<211> 2331
<212> DNA
<213> Homo sapiens
<308> XM_009097
<400> 548

cccagttgt  gatcttatg  aagacgctg  acgaccccg  gcccgcttg  cgccacggc  60
cttgaggca  ccggagata  tctgagtta  tcggagccc  acgcctgag  gtgagatga  120
cgcgctggc  tccctaacc  tccggacct  tgatcgctt  tggcagacc  aaccggcgc  180
cctgccccc  gggtgacgc  cagctccca  ccgcccaga  acatggccc  aggccaagc  240
ccccatcag  ctaccccgt  gagggatgc  caccctttc  tcctcctgt  cccagtgat  300
ggcctcctc  gccgcgcct  gagccgcct  aggggcctg  gacctctag  gccctggct  360
gtggaagca  taaaaggag  agctctggt  gaagctggc  tggagggag  agctaggac  420
cctctggca  tcccccata  cccttgggg  agacgccct  aagaggagg  tgaagacag  480
ggaggccct  gagaggaca  agaaacact  gggctgaaa  ccagcagtt  ccttcctga  540
gcctgggga  ttttggatg  tgatgatgg  atgtatggt  agcgagagg  aaccagtgt  600
cctagaggg  agggaagtc  atttgcaga  ggccagcgt  ctcccctgt  tcccagcct  660
ctgataagg  cactgcaag  ttctgataa  aacccaggg  aggagaaag  cgaggaaga  720
ggagttgct  aagaggagg  agttaacaa  ttctcttat  caccatcac  ccgggagtg  780
tgtccagcc  tggaggagg  ggacgatga  gaagctgta  agaaagaag  tcacagaac  840
tctacttct  ccttgtctc  aggatccaa  cccagcact  gggtgtctt  cccagggga  900
gaagagaat  aagccacgg  ggataaaag  acagaaaga  gtaaaggag  caggaagac  960
tccgtgtcc  cccgatctt  aggctccga  cccaggtcc  gggagtatc  ttcaggaga  1020
gcgtccgag  agaaggagg  aaaggcaca  aaagaaact  ggaaaggag  agctgcccc  1080
gggccgcaa  cctcagccc  agcccagag  ccccagctc  agtcctggt  gtgccaacc  1140
agtgatgaa  aggagggtg  ggtcaaggc  ttgggggca  ctgagaagg  tggagaagc  1200
gagtgtcct  cctgcatcc  cccaccaag  gccttcctg  aggcctggg  gtattggcc  1260
ggagaggac  cagaggaag  ggaagatga  gaagaagat  aggacagtg  ctctggatc  1320
gatgaggaa  agggagaag  tgaggcttc  tcttccact  ctgctacag  tgtcttctt  1380
aagtcctgg  tctatcagc  aggagagga  acagaggag  aggaagatg  ggacagtga  1440
acaggatca  ccgaggatg  aagagaagc  gagacttct  cttccacac  ccctgcaag  1500
gctttcttg  aggcctggg  gtatcggcc  ggagaggac  cggaggagg  ggaagatga  1560
gatgtggat  gtgaggata  ggaagatga  tcagaagca  ccttgggag  agctgagtc  1620
gacccacat  cctcccacc  ggaccagag  gcccacttc  ggggctggg  atatcgacc  1680
ggaaaagag  cagaggaag  ggaagctgc  gaggactgg  gagaagctg  gccctgccc  1740
ttccgagtg  ccatctatg  acctggaga  aagccaccg  ctccctggg  tcctcctag  1800
ctgcccctc  gactgcaaa  gcggctcaa  cgcccagaa  cccctactc  tgatccgga  1860
cctgagact  ccctaaagg  cagaaaggt  cgcttctcc  agaaggtca  tgtccattt  1920
ctggctgtc  gggcagggc  ggcccaggc  gcccgccag  gcccctggg  gcagcttgc  1980
cgggatcgc  gccgcttcg  acgccgcat  acccaggcc  aggaggagc  gagcccctg  2040
ctcacccct  ctgcccggg  cagagcctg  gcacgcctc  ggaacccac  tttagcccc  2100
atccctgcc  tcacccaga  cttgccttc  tcctctgtc  cttcgtccc  agtccagac  2160
acgcccttg  gccaagctg  ggccacacc  tcccgctcg  ctgctgctg  agcggctgc  2220
ctggacctc  gtgggaggc  tggctgaga  caactggtt  gcctataat  tattaacta  2280
ttatttttt  taagtgtgg  tttatataa  gaataaagc  ttttgattt  t  2331



<210> 549
<211> 674
<212> PRT
<213> Homo sapiens
<308> XP_009097
<400> 549

Met Ala Pro Gly Gln Ala Pro His Gln Ala Thr Pro Trp Arg Asp Ala 
  1               5                  10                  15
His Pro Phe Phe Leu Leu Ser Pro Val Met Gly Leu Leu Ser Arg Ala 
             20                  25                  30
Trp Ser Arg Leu Arg Gly Leu Gly Pro Leu Glu Pro Trp Leu Val Glu 
         35                  40                  45
Ala Val Lys Gly Ala Ala Leu Val Glu Ala Gly Leu Glu Gly Glu Ala 
     50                  55                  60
Arg Thr Pro Leu Ala Ile Pro His Thr Pro Trp Gly Arg Arg Pro Glu 
 65                  70                  75                  80
Glu Glu Ala Glu Asp Ser Gly Gly Pro Gly Glu Asp Arg Glu Thr Leu 
                 85                  90                  95
Gly Leu Lys Thr Ser Ser Ser Leu Pro Glu Ala Trp Gly Leu Leu Asp 
             100                105                110
Asp Asp Asp Gly Met Tyr Gly Glu Arg Glu Ala Thr Ser Val Pro Arg 
         115                120                125
Gly Gln Gly Ser Gln Phe Ala Asp Gly Gln Arg Ala Pro Leu Ser Pro 
     130                135                140
Ser Leu Leu Ile Arg Thr Leu Gln Gly Ser Asp Lys Asn Pro Gly Glu 
 145                150                155                160
Glu Lys Ala Glu Glu Glu Gly Val Ala Glu Glu Glu Gly Val Asn Lys 
                 165                170                175
Phe Ser Tyr Pro Pro Ser His Arg Glu Cys Cys Pro Ala Val Glu Glu 
             180                185                190
Glu Asp Asp Glu Glu Ala Val Lys Lys Glu Ala His Arg Thr Ser Thr 
         195                200                205
Ser Ala Leu Ser Pro Gly Ser Lys Pro Ser Thr Trp Val Ser Cys Pro 
     210                215                220
Gly Glu Glu Glu Asn Gln Ala Thr Glu Asp Lys Arg Thr Glu Arg Ser 
 225                230                235                240
Lys Gly Ala Arg Lys Thr Ser Val Ser Pro Arg Ser Ser Gly Ser Asp 
                 245                250                255
Pro Arg Ser Trp Glu Tyr Arg Ser Gly Glu Ala Ser Glu Glu Lys Glu 
             260                265                270
Glu Lys Ala His Lys Glu Thr Gly Lys Gly Glu Ala Ala Pro Gly Pro 
         275                280                285
Gln Ser Ser Ala Pro Ala Gln Arg Pro Gln Leu Lys Ser Trp Trp Cys 
     290                295                300
Gln Pro Ser Asp Glu Glu Glu Gly Glu Val Lys Ala Leu Gly Ala Ala 
 305                310                315                320
Glu Lys Asp Gly Glu Ala Glu Cys Pro Pro Cys Ile Pro Pro Pro Ser 
                 325                330                335
Ala Phe Leu Lys Ala Trp Val Tyr Trp Pro Gly Glu Asp Thr Glu Glu 
             340                345                350
Glu Glu Asp Glu Glu Glu Asp Glu Asp Ser Asp Ser Gly Ser Asp Glu 
         355                360                365
Glu Glu Gly Glu Ala Glu Ala Ser Ser Ser Thr Pro Ala Thr Gly Val 
     370                375                380
Phe Leu Lys Ser Trp Val Tyr Gln Pro Gly Glu Asp Thr Glu Glu Glu 
 385                390                395                400
Glu Asp Glu Asp Ser Asp Thr Gly Ser Ala Glu Asp Glu Arg Glu Ala 
                 405                410                415
Glu Thr Ser Ala Ser Thr Pro Pro Ala Ser Ala Phe Leu Lys Ala Trp 
             420                425                430
Val Tyr Arg Pro Gly Glu Asp Thr Glu Glu Glu Glu Asp Glu Asp Val 
         435                440                445
Asp Ser Glu Asp Lys Glu Asp Asp Ser Glu Ala Ala Leu Gly Glu Ala 
     450                455                460
Glu Ser Asp Pro His Pro Ser His Pro Asp Gln Arg Ala His Phe Arg 
 465                470                475                480
Gly Trp Gly Tyr Arg Pro Gly Lys Glu Thr Glu Glu Glu Glu Ala Ala 
                 485                490                495
Glu Asp Trp Gly Glu Ala Glu Pro Cys Pro Phe Arg Val Ala Ile Tyr 
             500                505                510
Val Pro Gly Glu Lys Pro Pro Pro Pro Trp Ala Pro Pro Arg Leu Pro 
         515                520                525
Leu Arg Leu Gln Arg Arg Leu Lys Arg Pro Glu Thr Pro Thr His Asp 
     530                535                540
Pro Asp Pro Glu Thr Pro Leu Lys Ala Arg Lys Val Arg Phe Ser Glu 
 545                550                555                560
Lys Val Thr Val His Phe Leu Ala Val Trp Ala Gly Pro Ala Gln Ala 
                 565                570                575
Ala Arg Gln Gly Pro Trp Glu Gln Leu Ala Arg Asp Arg Ser Arg Phe 
             580                585                590
Ala Arg Arg Ile Thr Gln Ala Gln Glu Glu Leu Ser Pro Cys Leu Thr 
         595                600                605
Pro Ala Ala Arg Ala Arg Ala Trp Ala Arg Leu Arg Asn Pro Pro Leu 
     610                615                620
Ala Pro Ile Pro Ala Leu Thr Gln Thr Leu Pro Ser Ser Ser Val Pro 
 625                630                635                640
Ser Ser Pro Val Gln Thr Thr Pro Leu Ser Gln Ala Val Ala Thr Pro 
                 645                650                655
Ser Arg Ser Ser Ala Ala Ala Ala Ala Ala Leu Asp Leu Ser Gly Arg 
             660                665                670
Arg Gly 
         675



<210> 550
<211> 2225
<212> DNA
<213> Rattus norvegicus
<308> AF020618
<400> 550

ctgcagtac  tgtacattg  taaataaag  gagggactc  aggaggagc  gcctgggtc  60
aagaggtag  cagaaggag  ttttagggg  ctgagcaca  gcttgagga  agaaaggtt  120
ttaaaaagc  agacgctta  aggtctcag  agggctagc  agaaactgt  gctggggtt  180
aggaaaggg  ttaagagtg  gggcttttg  ttctgagga  gtagaacgt  aatgttgag  240
gaagaacca  gtggcggag  tgggtgtga  caatgctat  aggaatttg  ggcagggat  300
cacgcgctg  tgtgactat  ttttaacaa  gactcagtg  tgtgacctg  tactgtttc  360
agagcgact  ctaaacaaa  tcccccttt  taggccaga  acatggccc  aagcccaag  420
ccccagcat  tcctgcact  gaaggaagc  cactctttc  acctcctgt  tccactgat  480
ggcttcctc  gccgggcct  gagccgcct  agggggccc  aggtctcag  ggcctggtt  540
gcagaaaca  tagcaggag  aaaccagat  gaggctgat  ctctgttga  gcctccccc  600
gtctctgaa  atcacctac  tctccgaga  actgaagga  atggaactc  tgaatggag  660
aaagcagcc  agaggctct  ccttgatgt  gaagcccaa  gttcccctc  taaaacttg  720
ggactttca  atattgatg  acataatgg  aagccagga  aagatggcc  tagagagca  780
gaagtggag  acacagctg  cctgcctac  ctacagccc  ttcacctgc  aggggcaga  840
aagaaagtt  gggaggtgg  ggctagaga  gagggtgtg  ccgagctgg  ttaccccac  900
tcacactgg  agggtggtc  agctgagga  gaagaggat  cagaaaccg  gaagaaggc  960
caccaggcc  ctgctgctt  catagctcc  ggatataaa  ccagcactt  tgtgtattg  1020
ccaggggag  cagaacatc  agccacgga  gaaaaagga  cagacaata  ggctgaacc  1080
tcaggctcc  actccagag  ctgggagta  cacactaga  agaggccta  gcaggaggg  1140
gaaactaag  cagagcaac  cagggcagg  cagagtcac  cttgtcaga  tgcagaggc  1200
gaggaagga  gacctgaga  ttctgtctg  tctggcagt  ccttcctga  ggcctgggt  1260
tatcgccca  gagaggaca  agaggagga  gaagacagt  atttggatt  agctgagga  1320
gacacagct  atacctgta  cacccccca  acaagtgcc  tcctgaagg  ctgggtcta  1380
cgcccagga  aggacacag  agaggaaga  gacggtgat  gggattcag  tgaggaaga  1440
gcgtctcag  gctgtacca  cccccatac  agtgccttc  tgaaggcct  ggtctatcg  1500
ccaggagag  acacagaag  ggaagacga  agtgagaat  tggccccag  tgactcaga  1560
acagttgac  cttgccaga  tacccagca  tgtctacca  tagagaaga  caagggatg  1620
ggagaagca  agccccctc  cttccagtg  ccttctatt  acctggaca  aagccagca  1680
caccttggg  tgcccctaa  ctgcccctt  gactgcaga  gcggctcag  tctttcaaa  1740
cccccgccc  gaatcaggg  cctgagatt  ctctgaagg  tagaaaggt  cacttctct  1800
agaaagtta  agtccattt  cttgctgtc  gggcaggac  agcccaggc  gctcgtcga  1860
gcccctggg  gcagtttgc  cgagatcga  gccgctttg  tcgacgcat  gccaggcag  1920
ggagcagct  ggtccttac  ttacccctg  tttcagggc  agagcatgg  cacgcctta  1980
aaacctacc  cttcctctg  cgtcctcgt  tcttccact  cctgagcct  gctcttcca  2040
tgaggccac  cccctcagc  aagatgtga  cactccctc  ccccttccc  gtgaaatcc  2100
tcctcccag  ctggacttg  gaggaaggc  ggctaagcc  gagtagttt  ttgtgtatt  2160
tatgagtgt  agtctctta  tacgaatat  taacgcctt  tgcatttgt  aaaaaaaaa  2220
aaaaa  2225



<210> 551
<211> 457
<212> PRT
<213> Rattus norvegicus
<308> AAC24980
<400> 551

Met Ala Pro Ser Pro Arg Pro Gln His Val Leu His Trp Lys Glu Ala 
  1               5                  10                  15
His Ser Phe Tyr Leu Leu Ser Pro Leu Met Gly Phe Leu Ser Arg Ala 
             20                  25                  30
Trp Ser Arg Leu Arg Gly Pro Glu Val Ser Glu Ala Trp Leu Ala Glu 
         35                  40                  45
Thr Val Ala Gly Ala Asn Gln Ile Glu Ala Asp Ala Leu Leu Thr Pro 
     50                  55                  60
Pro Pro Val Ser Glu Asn His Leu Pro Leu Arg Glu Thr Glu Gly Asn 
 65                  70                  75                  80
Gly Thr Pro Glu Trp Ser Lys Ala Ala Gln Arg Leu Cys Leu Asp Val 
                 85                  90                  95
Glu Ala Gln Ser Ser Pro Pro Lys Thr Trp Gly Leu Ser Asp Ile Asp 
             100                105                110
Glu His Asn Gly Lys Pro Gly Gln Asp Gly Leu Arg Glu Gln Glu Val 
         115                120                125
Glu His Thr Ala Gly Leu Pro Thr Leu Gln Pro Leu His Leu Gln Gly 
     130                135                140
Ala Asp Lys Lys Val Gly Glu Val Val Ala Arg Glu Glu Gly Val Ser 
 145                150                155                160
Glu Leu Ala Tyr Pro Thr Ser His Trp Glu Gly Gly Pro Ala Glu Asp 
                 165                170                175
Glu Glu Asp Thr Glu Thr Val Lys Lys Ala His Gln Ala Ser Ala Ala 
             180                185                190
Ser Ile Ala Pro Gly Tyr Lys Pro Ser Thr Ser Val Tyr Cys Pro Gly 
         195                200                205
Glu Ala Glu His Arg Ala Thr Glu Glu Lys Gly Thr Asp Asn Lys Ala 
     210                215                220
Glu Pro Ser Gly Ser His Ser Arg Val Trp Glu Tyr His Thr Arg Glu 
 225                230                235                240
Arg Pro Lys Gln Glu Gly Glu Thr Lys Pro Glu Gln His Arg Ala Gly 
                 245                250                255
Gln Ser His Pro Cys Gln Asn Ala Glu Ala Glu Glu Gly Gly Pro Glu 
             260                265                270
Thr Ser Val Cys Ser Gly Ser Ala Phe Leu Lys Ala Trp Val Tyr Arg 
         275                280                285
Pro Gly Glu Asp Thr Glu Glu Glu Glu Asp Ser Asp Leu Asp Ser Ala 
     290                295                300
Glu Glu Asp Thr Ala His Thr Cys Thr Thr Pro His Thr Ser Ala Phe 
 305                310                315                320
Leu Lys Ala Trp Val Tyr Arg Pro Gly Glu Asp Thr Glu Glu Glu Asp 
                 325                330                335
Asp Gly Asp Trp Asp Ser Ala Glu Glu Asp Ala Ser Gln Ser Cys Thr 
             340                345                350
Thr Pro His Thr Ser Ala Phe Leu Lys Ala Trp Val Tyr Arg Pro Gly 
         355                360                365
Glu Asp Thr Glu Glu Glu Asp Asp Ser Glu Asn Val Ala Pro Val Asp 
     370                375                380
Ser Glu Thr Val Asp Ser Cys Gln Ser Thr Gln His Cys Leu Pro Val 
 385                390                395                400
Glu Lys Thr Lys Gly Cys Gly Glu Ala Glu Pro Pro Pro Phe Gln Trp 
                 405                410                415
Pro Ser Ile Tyr Leu Asp Arg Ser Gln His His Leu Gly Leu Pro Leu 
             420                425                430
Ser Cys Pro Phe Asp Cys Arg Ser Gly Ser Asp Leu Ser Lys Pro Pro 
         435                440                445
Pro Gly Ile Arg Ala Leu Arg Phe Leu 
     450                455



<210> 552
<211> 2331
<212> DNA
<213> Homo sapiens
<308> XM_009097
<400> 552

cccagttgt  gatcttatg  aagacgctg  acgaccccg  gcccgcttg  cgccacggc  60
cttgaggca  ccggagata  tctgagtta  tcggagccc  acgcctgag  gtgagatga  120
cgcgctggc  tccctaacc  tccggacct  tgatcgctt  tggcagacc  aaccggcgc  180
cctgccccc  gggtgacgc  cagctccca  ccgcccaga  acatggccc  aggccaagc  240
ccccatcag  ctaccccgt  gagggatgc  caccctttc  tcctcctgt  cccagtgat  300
ggcctcctc  gccgcgcct  gagccgcct  aggggcctg  gacctctag  gccctggct  360
gtggaagca  taaaaggag  agctctggt  gaagctggc  tggagggag  agctaggac  420
cctctggca  tcccccata  cccttgggg  agacgccct  aagaggagg  tgaagacag  480
ggaggccct  gagaggaca  agaaacact  gggctgaaa  ccagcagtt  ccttcctga  540
gcctgggga  ttttggatg  tgatgatgg  atgtatggt  agcgagagg  aaccagtgt  600
cctagaggg  agggaagtc  atttgcaga  ggccagcgt  ctcccctgt  tcccagcct  660
ctgataagg  cactgcaag  ttctgataa  aacccaggg  aggagaaag  cgaggaaga  720
ggagttgct  aagaggagg  agttaacaa  ttctcttat  caccatcac  ccgggagtg  780
tgtccagcc  tggaggagg  ggacgatga  gaagctgta  agaaagaag  tcacagaac  840
tctacttct  ccttgtctc  aggatccaa  cccagcact  gggtgtctt  cccagggga  900
gaagagaat  aagccacgg  ggataaaag  acagaaaga  gtaaaggag  caggaagac  960
tccgtgtcc  cccgatctt  aggctccga  cccaggtcc  gggagtatc  ttcaggaga  1020
gcgtccgag  agaaggagg  aaaggcaca  aaagaaact  ggaaaggag  agctgcccc  1080
gggccgcaa  cctcagccc  agcccagag  ccccagctc  agtcctggt  gtgccaacc  1140
agtgatgaa  aggagggtg  ggtcaaggc  ttgggggca  ctgagaagg  tggagaagc  1200
gagtgtcct  cctgcatcc  cccaccaag  gccttcctg  aggcctggg  gtattggcc  1260
ggagaggac  cagaggaag  ggaagatga  gaagaagat  aggacagtg  ctctggatc  1320
gatgaggaa  agggagaag  tgaggcttc  tcttccact  ctgctacag  tgtcttctt  1380
aagtcctgg  tctatcagc  aggagagga  acagaggag  aggaagatg  ggacagtga  1440
acaggatca  ccgaggatg  aagagaagc  gagacttct  cttccacac  ccctgcaag  1500
gctttcttg  aggcctggg  gtatcggcc  ggagaggac  cggaggagg  ggaagatga  1560
gatgtggat  gtgaggata  ggaagatga  tcagaagca  ccttgggag  agctgagtc  1620
gacccacat  cctcccacc  ggaccagag  gcccacttc  ggggctggg  atatcgacc  1680
ggaaaagag  cagaggaag  ggaagctgc  gaggactgg  gagaagctg  gccctgccc  1740
ttccgagtg  ccatctatg  acctggaga  aagccaccg  ctccctggg  tcctcctag  1800
ctgcccctc  gactgcaaa  gcggctcaa  cgcccagaa  cccctactc  tgatccgga  1860
cctgagact  ccctaaagg  cagaaaggt  cgcttctcc  agaaggtca  tgtccattt  1920
ctggctgtc  gggcagggc  ggcccaggc  gcccgccag  gcccctggg  gcagcttgc  1980
cgggatcgc  gccgcttcg  acgccgcat  acccaggcc  aggaggagc  gagcccctg  2040
ctcacccct  ctgcccggg  cagagcctg  gcacgcctc  ggaacccac  tttagcccc  2100
atccctgcc  tcacccaga  cttgccttc  tcctctgtc  cttcgtccc  agtccagac  2160
acgcccttg  gccaagctg  ggccacacc  tcccgctcg  ctgctgctg  agcggctgc  2220
ctggacctc  gtgggaggc  tggctgaga  caactggtt  gcctataat  tattaacta  2280
ttatttttt  taagtgtgg  tttatataa  gaataaagc  ttttgattt  t  2331



<210> 553
<211> 674
<212> PRT
<213> Homo sapiens
<308> XP_009097
<400> 553

Met Ala Pro Gly Gln Ala Pro His Gln Ala Thr Pro Trp Arg Asp Ala 
  1               5                  10                  15
His Pro Phe Phe Leu Leu Ser Pro Val Met Gly Leu Leu Ser Arg Ala 
             20                  25                  30
Trp Ser Arg Leu Arg Gly Leu Gly Pro Leu Glu Pro Trp Leu Val Glu 
         35                  40                  45
Ala Val Lys Gly Ala Ala Leu Val Glu Ala Gly Leu Glu Gly Glu Ala 
     50                  55                  60
Arg Thr Pro Leu Ala Ile Pro His Thr Pro Trp Gly Arg Arg Pro Glu 
 65                  70                  75                  80
Glu Glu Ala Glu Asp Ser Gly Gly Pro Gly Glu Asp Arg Glu Thr Leu 
                 85                  90                  95
Gly Leu Lys Thr Ser Ser Ser Leu Pro Glu Ala Trp Gly Leu Leu Asp 
             100                105                110
Asp Asp Asp Gly Met Tyr Gly Glu Arg Glu Ala Thr Ser Val Pro Arg 
         115                120                125
Gly Gln Gly Ser Gln Phe Ala Asp Gly Gln Arg Ala Pro Leu Ser Pro 
     130                135                140
Ser Leu Leu Ile Arg Thr Leu Gln Gly Ser Asp Lys Asn Pro Gly Glu 
 145                150                155                160
Glu Lys Ala Glu Glu Glu Gly Val Ala Glu Glu Glu Gly Val Asn Lys 
                 165                170                175
Phe Ser Tyr Pro Pro Ser His Arg Glu Cys Cys Pro Ala Val Glu Glu 
             180                185                190
Glu Asp Asp Glu Glu Ala Val Lys Lys Glu Ala His Arg Thr Ser Thr 
         195                200                205
Ser Ala Leu Ser Pro Gly Ser Lys Pro Ser Thr Trp Val Ser Cys Pro 
     210                215                220
Gly Glu Glu Glu Asn Gln Ala Thr Glu Asp Lys Arg Thr Glu Arg Ser 
 225                230                235                240
Lys Gly Ala Arg Lys Thr Ser Val Ser Pro Arg Ser Ser Gly Ser Asp 
                 245                250                255
Pro Arg Ser Trp Glu Tyr Arg Ser Gly Glu Ala Ser Glu Glu Lys Glu 
             260                265                270
Glu Lys Ala His Lys Glu Thr Gly Lys Gly Glu Ala Ala Pro Gly Pro 
         275                280                285
Gln Ser Ser Ala Pro Ala Gln Arg Pro Gln Leu Lys Ser Trp Trp Cys 
     290                295                300
Gln Pro Ser Asp Glu Glu Glu Gly Glu Val Lys Ala Leu Gly Ala Ala 
 305                310                315                320
Glu Lys Asp Gly Glu Ala Glu Cys Pro Pro Cys Ile Pro Pro Pro Ser 
                 325                330                335
Ala Phe Leu Lys Ala Trp Val Tyr Trp Pro Gly Glu Asp Thr Glu Glu 
             340                345                350
Glu Glu Asp Glu Glu Glu Asp Glu Asp Ser Asp Ser Gly Ser Asp Glu 
         355                360                365
Glu Glu Gly Glu Ala Glu Ala Ser Ser Ser Thr Pro Ala Thr Gly Val 
     370                375                380
Phe Leu Lys Ser Trp Val Tyr Gln Pro Gly Glu Asp Thr Glu Glu Glu 
 385                390                395                400
Glu Asp Glu Asp Ser Asp Thr Gly Ser Ala Glu Asp Glu Arg Glu Ala 
                 405                410                415
Glu Thr Ser Ala Ser Thr Pro Pro Ala Ser Ala Phe Leu Lys Ala Trp 
             420                425                430
Val Tyr Arg Pro Gly Glu Asp Thr Glu Glu Glu Glu Asp Glu Asp Val 
         435                440                445
Asp Ser Glu Asp Lys Glu Asp Asp Ser Glu Ala Ala Leu Gly Glu Ala 
     450                455                460
Glu Ser Asp Pro His Pro Ser His Pro Asp Gln Arg Ala His Phe Arg 
 465                470                475                480
Gly Trp Gly Tyr Arg Pro Gly Lys Glu Thr Glu Glu Glu Glu Ala Ala 
                 485                490                495
Glu Asp Trp Gly Glu Ala Glu Pro Cys Pro Phe Arg Val Ala Ile Tyr 
             500                505                510
Val Pro Gly Glu Lys Pro Pro Pro Pro Trp Ala Pro Pro Arg Leu Pro 
         515                520                525
Leu Arg Leu Gln Arg Arg Leu Lys Arg Pro Glu Thr Pro Thr His Asp 
     530                535                540
Pro Asp Pro Glu Thr Pro Leu Lys Ala Arg Lys Val Arg Phe Ser Glu 
 545                550                555                560
Lys Val Thr Val His Phe Leu Ala Val Trp Ala Gly Pro Ala Gln Ala 
                 565                570                575
Ala Arg Gln Gly Pro Trp Glu Gln Leu Ala Arg Asp Arg Ser Arg Phe 
             580                585                590
Ala Arg Arg Ile Thr Gln Ala Gln Glu Glu Leu Ser Pro Cys Leu Thr 
         595                600                605
Pro Ala Ala Arg Ala Arg Ala Trp Ala Arg Leu Arg Asn Pro Pro Leu 
     610                615                620
Ala Pro Ile Pro Ala Leu Thr Gln Thr Leu Pro Ser Ser Ser Val Pro 
 625                630                635                640
Ser Ser Pro Val Gln Thr Thr Pro Leu Ser Gln Ala Val Ala Thr Pro 
                 645                650                655
Ser Arg Ser Ser Ala Ala Ala Ala Ala Ala Leu Asp Leu Ser Gly Arg 
             660                665                670
Arg Gly 
         675



<210> 554
<211> 1278
<212> DNA
<213> Rattus norvegicus
<308> AF020712
<400> 554

atctgtttc  caggagact  tggaaaacg  aggggcaga  tccccaaca  cagctgagg  60
ctcgaagag  ctaggtacc  gcttgtgga  ttttttgtc  cggagcaag  tgtgtgctc  120
gacttgacc  tgtttgggc  tggaggctc  acccagatg  aactgaaga  tgcttccct  180
gagaccaac  ggagaccaa  cttcctgct  gagctccaa  gcctgactt  gggtggggg  240
gtgggggcc  gtggagaga  accatctgc  agcggagac  cagggaact  aatgactgt  300
gcctcctgt  gccatgggg  agaagctgg  gatggccca  aagcgcgga  agactcgag  360
cctctgcct  ggggtggcg  tggtcgtgt  tgccgccat  acttactac  tcctgggta  420
cactgtgct  cccctctac  agaaaagtg  gtggaccca  gaatccacc  gtcacttgg  480
tgaaaccaa  atcaaggac  aggaagagc  ggagggcag  aaggtgccc  agtacccat  540
cctttgggt  aatgtatca  ctgtgggca  atgggccat  ctgtatcac  cagaagaca  600
tcgggatca  aaccaacag  gctcctata  ccccaggaa  ctggacaac  accagacag  660
cttggttga  gtgaagaag  tcagagcca  tttctacaa  caccataat  tctattgct  720
ttctgcacc  caagtcaat  agaccagtg  tgtgtacca  cgcctctat  ggccccaaa  780
cctcctctt  tccttcttc  ggcccacct  cctgctgac  ggtggcctt  ttatcattg  840
catggtaaa  ctcaacagg  ccctctctg  cttggcagc  cagaagtag  ccaatctct  900
ctgcacagc  gcatggagt  accaggaac  gcaggggtc  cgggcaggc  taattctct  960
cctcttgtc  tccatttaa  ttgttcaac  tctttggac  atcatttct  gctcaagaa  1020
gtttaacag  tctctccgg  tgacttcga  gggcaaagg  actgccagt  acagctctc  1080
atccccggc  tcagttggc  cacatctgt  acctgctat  tcactgtct  ctcccaaga  1140
gatgaatat  gtcacctct  tccctatgt  ctctctctt  gttcctcag  tacccacct  1200
tgacatcca  gatgctgtc  ttggccaaa  tcagcttct  tgaattgtc  taaaagcca  1260
agctctcaa  aaaaaaaa  1278



<210> 555
<211> 191
<212> PRT
<213> Rattus norvegicus
<308> AAD11858
<400> 555

Met Gly Lys Lys Leu Val Met Ala Gln Lys Arg Gly Glu Thr Arg Ala 
  1               5                  10                  15
Leu Cys Leu Gly Val Ala Met Val Val Cys Ala Ala Ile Thr Tyr Tyr 
             20                  25                  30
Ile Leu Gly Thr Thr Val Leu Pro Leu Tyr Gln Lys Ser Val Trp Thr 
         35                  40                  45
Gln Glu Ser Thr Cys His Leu Val Glu Thr Asn Ile Lys Asp Gln Glu 
     50                  55                  60
Glu Leu Glu Gly Arg Lys Val Pro Gln Tyr Pro Cys Leu Trp Val Asn 
 65                  70                  75                  80
Val Ser Ala Val Gly Arg Trp Ala Met Leu Tyr His Thr Glu Asp Thr 
                 85                  90                  95
Arg Asp Gln Asn Gln Gln Cys Ser Tyr Ile Pro Arg Asn Leu Asp Asn 
             100                105                110
Tyr Gln Thr Ala Leu Val Asp Val Lys Lys Val Arg Ala Asn Phe Tyr 
         115                120                125
Lys His His Asn Phe Tyr Cys Phe Ser Ala Pro Gln Val Asn Glu Thr 
     130                135                140
Ser Val Val Tyr Gln Arg Leu Tyr Gly Pro Gln Ile Leu Leu Phe Ser 
 145                150                155                160
Phe Phe Trp Pro Thr Phe Leu Leu Thr Gly Gly Leu Leu Ile Ile Ala 
                 165                170                175
Met Val Lys Leu Asn Arg Ser Leu Ser Val Leu Ala Ala Gln Lys 
             180                185                190



<210> 556
<211> 1277
<212> DNA
<213> Homo sapiens
<308> NM_004137
<400> 556

aagctgctt  cctggagac  ggcggggag  ccaaacttc  tgctgaagc  ctgtggcct  60
ttttggggt  ggggcgggg  tccaggcag  aagaaactg  ctgctgctc  agacccaca  120
gacgcccgg  agactaaat  atcactgcc  ccagtgaat  tggtgaaga  gctggtgat  180
gcccagaag  ggggagaga  acgagccct  tgcctgggt  taaccatgg  ggtgtgtgc  240
gtcatcacc  actacatcc  ggtcacgac  gtgctgccc  tctaccaga  aagcgtgtg  300
acccaggaa  ccaagtgcc  cctgattga  accaacatc  gggaccagg  ggagctgaa  360
ggcaagaag  tgccccagt  cccatgcct  tgggtcaac  tgtcagctg  cggcaggtg  420
gctgtgctg  accacacgg  ggacactcg  gaccagaac  agcagtgct  ctacatccc  480
ggcagcgtg  acaattacc  gacggcccg  gccgacgtg  agaaggtca  agccaaatt  540
caagagcag  aggtcttct  ctgcttctc  gcacctcgg  ggaacgaaa  cagcgtcct  600
ttccagcgc  tctacgggc  ccaggccct  ctcttctcc  tcttctggc  caccttcct  660
ctgaccggt  gcctcctca  tatcgccat  gtgaagagc  accagtacc  gtccatcct  720
gcggcccag  agtagagcc  tccatccat  ccataccac  tgtcagggc  caggggact  780
gctgggccc  cagggctgc  ccccacttg  agcacaatg  cttctccac  tgccctccc  840
ctcttccag  ccaatccac  ctgtcttct  ttgcaggac  aacctttga  aaatccttt  900
gtgaagtca  tgcctgctc  agaatgtac  gtggctccc  aatgccttg  aggccataa  960
gccagccag  tctagctct  tattacctg  ccccactca  ctgactcat  cctgtttcc  1020
gctgcatca  tatgtgccc  acagagaac  atgatcgtc  cctctgtgc  tgagttctc  1080
ctgttgtct  aaagcggta  ccatcctcc  ccagaagct  tccccagcg  gcctccctt  1140
tttgtttga  ttctctaat  agagcaaca  cagctccca  ttctagaac  catttacag  1200
attactatt  tctaggata  aaagtgcca  atatatttt  aattccaat  ttaataaat  1260
tatgccaaa  aacaata  1277



<210> 557
<211> 190
<212> PRT
<213> Homo sapiens
<308> Q16558
<400> 557

Val Lys Lys Leu Val Met Ala Gln Lys Arg Gly Glu Thr Arg Ala Leu 
  1               5                  10                  15
Cys Leu Gly Val Thr Met Val Val Cys Ala Val Ile Thr Tyr Tyr Ile 
             20                  25                  30
Leu Val Thr Thr Val Leu Pro Leu Tyr Gln Lys Ser Val Trp Thr Gln 
         35                  40                  45
Glu Ser Lys Cys His Leu Ile Glu Thr Asn Ile Arg Asp Gln Glu Glu 
     50                  55                  60
Leu Lys Gly Lys Lys Val Pro Gln Tyr Pro Cys Leu Trp Val Asn Val 
 65                  70                  75                  80
Ser Ala Ala Gly Arg Trp Ala Val Leu Tyr His Thr Glu Asp Thr Arg 
                 85                  90                  95
Asp Gln Asn Gln Gln Cys Ser Tyr Ile Pro Gly Ser Val Asp Asn Tyr 
             100                105                110
Gln Thr Ala Arg Ala Asp Val Glu Lys Val Arg Ala Lys Phe Gln Glu 
         115                120                125
Gln Gln Val Phe Tyr Cys Phe Ser Ala Pro Arg Gly Asn Glu Thr Ser 
     130                135                140
Val Leu Phe Gln Arg Leu Tyr Gly Pro Gln Ala Leu Leu Phe Ser Leu 
 145                150                155                160
Phe Trp Pro Thr Phe Leu Leu Thr Gly Gly Leu Leu Ile Ile Ala Met 
                 165                170                175
Val Lys Ser Asn Gln Tyr Leu Ser Ile Leu Ala Ala Gln Lys 
             180                185                190



<210> 558
<211> 8942
<212> DNA
<213> Rattus norvegicus
<308> AF021923
<400> 558

gtggtgata  tttcctgtg  agagtaaag  ttcccaatt  tagaagagc  ccataagca  60
catccactg  gaagcaagg  gcagcatga  agagccgtc  gtgtgagtc  gaagtgtga  120
gaccaccat  tccaccaga  gatccaaga  ggatctcca  caaagcgcc  cagtcaggc  180
cctgcagga  tggtgttcc  atgagtcac  atctggctg  aggagacat  ataatacca  240
gaaaaaact  aagctaatt  gagtcattg  ccttgtcat  ggcctggta  ccgtgagca  300
tgtcccgtt  tcaatcagt  cctttactg  gacatactc  cagaacaac  gaggagaag  360
cagtgatgt  acgggccct  gggcagcac  cggtcaccg  caaagaact  tcttagact  420
aaatgacaa  attcgagat  acaccccac  gccacctgc  tctcaggaa  accgatctg  480
gaacggtac  gatcacgcc  agggagact  cccaaagga  gtcttttcc  tggaggagc  540
aaggaaagg  gccatcatt  tccatgtca  cggaatgat  tatatgttc  tagccttag  600
catcgtctg  gatgagttc  ttgttcctt  tctaactgt  atcactgaa  aactgggaa  660
ctctgatga  gtggccgga  ccaccttca  ggccgcagg  gggtcagcc  cagaacttt  720
cacatctct  ataggggtt  tcattgcgc  cagcaacgt  ggcattggc  ccatcgtag  780
ttccgccgt  ttcaatatc  tctttgtta  tggcatgtg  gctctgttt  ctagagaaa  840
cttaaacct  acctggtgg  cgctctttc  ggatgtgtc  ttctacatc  ttgatttga  900
catgttgat  atatttttc  tggataacg  tatcatgtg  tgggaaagc  tactcctct  960
aacagctta  ttcgcctat  tggttttca  gaagttcaa  gtccaagta  agagatggg  1020
gaagcaaat  ataaatcgc  ataaagttg  caaggtgac  gtgtcagaa  cccaagcca  1080
ggcatctac  gctggggac  aggaagagc  gacgttacc  aataagccg  gcctccagc  1140
aggtggaag  tctgcttcc  tccacaaca  tctcatgag  aacagcatc  tccagctca  1200
gatacacac  cttgaccca  tcgctgaag  acttggatc  tatggaaaa  taaaatatt  1260
tgacacaat  actgaagaa  ggaggttca  agaaaaagc  tcaattctc  acaagattg  1320
caagaagaa  tgccaagtg  atgagaatg  gaggcaaaa  ggagctgcc  atcatgtgg  1380
ttatgccgc  gaaaaaatt  agctcccca  cagcacgag  acagaggtg  aaatgactc  1440
atcaagcga  gcttcagaa  ctgtgcaga  tggaaacct  tctcacagc  tcgaagctg  1500
agacgcccc  caggccaca  agaccgccg  ggaagatga  gaccagccc  tcagcctgt  1560
ctggccgtc  aacacccgc  agcagatca  cttcctaat  gttcttccc  tcgtgttcc  1620
tctctggat  accttaccc  acgtccgca  acctgcttc  aagaagttc  tccctatca  1680
gttcttcgg  tccatcacc  ggatcgcag  tttctcgta  ctgatggtg  ggtgggcac  1740
ccaggttgg  gagacaatc  gcattagtg  ggagatcat  ggcctcacc  tcttggcag  1800
tggaacctc  atccccgat  tcatcacca  tgtcatagt  gcccgaaag  gcctggggg  1860
catggctgt  tccagctcc  ttggaagca  catctttga  atcactgtg  ggctcccac  1920
gccctggct  ctctacacc  tcatccaca  attcaagcc  gtgactgtc  gcagcaatg  1980
cctcttctg  gccatcgtc  tcctcttca  catgttgat  tttgtcatc  tctccatcg  2040
cctctgcaa  tggcggatg  acaaaatcc  cggcttcat  atgtttggc  tctacttcg  2100
gttcctggt  gtcagcgtc  tcctggaag  caaagttct  gagtgccct  tctccatct  2160
gtggaaaag  catatctta  accaacagc  tggatggtc  ctcccggct  tgggctcca  2220
gctccttgc  gtcttgaga  gaggcaact  gtgcacagc  ctgggaggc  agtgtccct  2280
cttgaaagg  tggaggaag  atggattcc  acggggcca  tcacttcac  ggcccctca  2340
ccttgcctg  tgaaatgac  ccgtgttag  gacaaagag  accgtctct  catccccac  2400
gacaggtac  cctcgctgg  cagaggtac  ttcattgtg  tgacgcgaa  gaggacaga  2460
gccatacat  catataaat  ttataaata  atacacatg  gcatacaga  cttgcctgt  2520
tctgtacta  acctctcct  ctataccta  agattaata  ataactgta  acaaacaga  2580
agaaaaatt  tatatatat  taaaaacat  tatatttaa  tgcaaatgc  tcttttcag  2640
gatagctct  gtatattta  agtacctat  tgaagaggg  catcaacct  caaccttca  2700
tttgtgctt  gcccctcga  tgcaaaagc  gagttaaca  aatcagtag  caaagcgct  2760
cttgctgtg  tctctagcc  gctttggat  gaataagtt  agtgaaata  tttgcagaa  2820
ggagagctt  atagaggga  tccgtagga  ccccagtta  aacctctaa  atactctca  2880
aagccaaaa  gaatcaccc  gctcatccc  actggggcg  tctgacacc  ccaggattc  2940
gtaagacag  ggtaaaact  agactgact  acaaccagg  ggcggggag  gtgcggcat  3000
tgttgaggg  taggctgtc  tgttttgtt  tgttttgtt  taatacccc  gcatgcaag  3060
agatgatat  aatgaaaaa  caaattagt  attttctag  acagcaaaa  tatataaac  3120
gagcctatc  tgttccagt  catggccca  tatcatcaa  cgaacaagg  caatcttag  3180
cgtgattgt  atttgacaa  ctttaatgc  aagggctcc  acacagtcc  aagtcctgc  3240
aagagtgct  agatgtgtg  tgagaaaca  catccagca  aggtgctca  tgggggtgg  3300
cacccgatg  gaacatagg  catagctcc  tagagcact  ctcagtgtg  tcacaaagg  3360
ctgcaatgt  taaggatca  tcccaatag  gctgaacta  ggaatgaca  tgcttgatt  3420
aggcagttc  ggtttgttt  cagagacat  tagccggtt  gtgtgtacc  caccccacc  3480
ccagaacag  ttccaagtc  tgtgtcacg  atttggtct  tagactcat  caacatctg  3540
atcccgcct  tatcatagc  ccgcctgga  ctgtagcat  ccaagcaca  tggagacta  3600
atatcttcc  tcatttctt  acattactt  gaagcagtc  ctcatatct  gatcagctt  3660
acatggggg  aatctcact  atggagtgt  cctaagctc  gaatgactt  aaagctctt  3720
tctgactcc  taagccctt  tgtgatttc  cgggttcat  tcagtagaa  atgggactg  3780
ttggcagca  gttaaattg  agaaaaaaa  tgtgccgag  ttttctttt  cctaaacca  3840
gctttctcc  taaaatcaa  tgaaaaagt  aataaaggg  ggccacctg  atgtaaatc  3900
gcacacgtc  tacacagag  atgtcacca  gcattcaca  cctgatctg  cactacgcc  3960
tttctgact  tcgtgaaca  cccttaaca  agggaggca  gacacagag  tcagagctg  4020
ataaaaagg  tgggtaacc  aatacccca  cccaagttc  gcattccat  tacaaacac  4080
ccatttaca  agcatggca  caggaggca  agccaagcc  catcacctc  cttcactca  4140
aagcaaaag  cacttcaaa  tggaggccc  ctgaggaca  gagaaataa  aaggtccgc  4200
tggctttca  gtctctcca  caatgcaga  ttgggtttt  aatggtgaa  gagaaatcc  4260
tgccccatt  atcaagggt  gaactttgt  tggggcaag  gtttgtgtt  cttccttac  4320
gagaaagac  aagggaaag  gagttttca  ttttcaaat  tcagattct  gtcccggct  4380
ctcgggcaa  agcccaatg  ttgttggat  aattctttt  cctgattgg  ttattgctt  4440
aaacggatt  tttttaaac  aactacaaa  agactgtaa  gtaaaaaag  tcacagaat  4500
tatgctcct  ccgttacta  cccctcctc  ccaaaaagc  aggaagcac  ccagatgcc  4560
aagagctga  agctctgct  catagggag  gttgtggtc  ttaacaaca  tcccaaagc  4620
agtccccac  tccacggtg  tccccctcc  tgagaggtg  aggtcccag  cgctgctgg  4680
tcttgctgc  tttgttgag  agtgtgtgg  tatgtggcc  tatgttgtc  tggaatcat  4740
cacatcatt  taaaactgc  tcctacagg  tagattcag  tcatttcta  tttctctct  4800
gcacatcag  gtgcgcaag  gtactagat  tgctggcac  caaatatca  tgccgccat  4860
accttattg  cccacccag  cacatttgg  atcccaaag  acagagtat  aaatttgac  4920
gtcaagaaa  agaaaactc  tgcacacca  ccaaagtga  catctatga  aaaaaaggg  4980
gttagtttt  ttctgtgca  atatacaca  aaacattca  atttaaaca  tccaacccc  5040
cagaatatt  gaaatggca  ctgtatccc  aatgctttc  gagaagcaa  agtatgcaa  5100
aagaggcag  ggagacaaa  tttagattg  tgtctcctt  tttctctgg  gcagggtac  5160
aaataatat  aaaagttca  gccaaaatt  taccactcc  aaaataaag  aattgggcc  5220
aaatttgct  acagaaaac  aagccagtc  tgcttgctg  cacctctcc  atagcctca  5280
gaaaccctg  aacaggaga  aaacttggt  cagattgag  attctaaag  agaaactcg  5340
agatttgca  ttgagagtg  ccatgacac  tccacctgc  ctctggacc  agtcagttc  5400
tagtgggat  gttggtgtt  ttcaagttc  caggaccga  acatgccag  cagagtcag  5460
agggcagag  acatgtgca  gcgctcggg  atggggctg  tcctcagct  agcagatga  5520
gcagaatgt  tgaagcctc  ctttagtgt  atgaaaaga  gcaaggacc  tctcatgat  5580
aaggaaacc  ctttgcagg  cctctgaca  aggccattg  aatttattt  gtagggaag  5640
catgagtca  gtggcttgg  ggcctttca  caaaacaca  ctgtctcca  gacaagatt  5700
ttggtaacc  taacataca  ctgctcctg  ccagagaga  ttgatccac  tcccttcac  5760
accacttcc  acatctttt  aatgcctct  tgacttgag  tgaagtgag  tgtggcctg  5820
aaaagaagg  tgtccacac  cagtccacc  taacagaaa  atgatcaca  aagagacaa  5880
tatcagagc  gctggccag  cagggggga  gatggaact  gaagtgttc  cttgagaga  5940
ttgcactga  gatttgata  ggtttgatg  ctgcctgaa  gaagcctgt  agagaattt  6000
agtgagctt  catacaagc  cacacacac  cacacacac  cacacacac  ccacacaca  6060
acacataca  acacacaca  acacacaca  accacacac  cacacatac  cacacacac  6120
cacacacac  cacaccaca  acacacaca  acacacaca  acacacaca  acacacaca  6180
acacacctc  gcatggaca  gcatacgca  aaattatat  cttccttgc  cccagaaag  6240
ttggggctc  atcaagtag  atgttagag  cagcaggtc  gtcgcagga  aagcatgct  6300
tagaaactt  caattagca  acaaggcct  cccattaag  gggagttgg  agaaaaata  6360
aaaaatcaa  ggggggagg  aggagagaa  ataacttat  agtaatggg  ttcctaaga  6420
agcaaccaa  atatatcat  atgttttaa  gtggttaca  atagcagac  tttttaaac  6480
attactgga  tctatacat  gcctacatt  gaaaagcac  tgtcaagaa  gactcagga  6540
agaaaggta  ctgtgcctt  ccccagtgt  tgtctgagc  tagtttact  cctttggat  6600
tttgtggtc  tttttaatc  cacagcttt  tattccttg  catgtataa  ctaagaaaa  6660
caataaagg  aatacagcc  gctcagatc  aataccgat  attgtacct  ccagctatt  6720
ccctcacgt  actgggcac  ttaggtcca  agaggctat  gtgccacag  aaggggaca  6780
tggcttctg  gcagtcaca  atgtgctca  gttcgctac  tctggaagt  gcttgcttc  6840
cacatagac  gcctagaca  catgcatcc  catgccttt  tcacacgta  acaatcaac  6900
tcgctttaa  ctacctaaa  ggcaccaaa  tctttaatc  tgctcatga  tctgttctt  6960
ggaaagggt  ggagagagg  ccacacaga  aaatgcatg  cctggccag  ctttgagag  7020
ccaacctag  cctgaaagt  taagcaccc  gactcgaat  attgtacag  gagggggac  7080
gaatggaga  gtatggtgc  taagccaaa  cacttttcc  aaatgaccg  tgggctgac  7140
ggaaaatta  taaatacct  agggtgaag  aatgccgtg  acttgcatg  actcccacc  7200
gagactgat  ccactgggg  aatctgtct  ctggttacc  tagtacaaa  gaccacaga  7260
agtaagtca  cttggaata  cagcaaaga  ttcctagtg  taccaaggt  aatgtttaa  7320
actgacaga  gagtcccca  ccagcttaa  cccccaaga  cctacagct  atgacttca  7380
ccttttttt  tttggttga  ttggtttgg  ttggtttcg  acacttttt  atcttacgc  7440
tgacaaggt  gaaagttgc  actctggga  cctacacct  ttttcttca  aagcatccc  7500
gaagttttt  tttgtttag  tgttttctt  agctttctc  tcttcctcc  cctcctcgt  7560
tttctcctc  tccttttct  ccttctgat  ccattattc  cacacagtg  aaagattca  7620
aagttctag  cctttaccc  caacagcac  tttctgtgc  tgactaatc  ccagaggag  7680
cctttctag  tgctactga  tggcaggca  aatccataa  cacagaggt  cataccttc  7740
aaggaccag  agacttgaa  gcggtacca  tgggagttg  ttgtctggt  tcaagatga  7800
cactggaca  agtgttatc  tagagttat  gttaggtca  ggttgtagc  ttttttgta  7860
cctgcatct  cgttccaca  agtcaaaaa  gaaacagga  aggagccac  ttgaatcat  7920
ccaagactc  gggtttgtg  ttgcctgca  tgattattg  gaggaagtc  tttcaaatg  7980
gaggtcaga  aaaggcttg  gctcctctt  ctatgagtc  cacagtgcg  ttactttcg  8040
atgcagtag  ttgatagaa  cagtgaggt  acttcctga  ctgggaatc  ggtcaccaa  8100
agatgggga  tttcccttc  gttgcagtt  cttcataat  gatatgtaa  taacggagc  8160
ttggacact  acgggtctc  agaactctc  gctagccaa  aagatacta  ttttctcaa  8220
tcaagttac  tacacacaa  caagaaaaa  gcaaaatgt  agaatccca  aataaaatc  8280
tttccagaa  gaaactgca  gtgtgaatt  agggcagag  attcctcgc  agttaaccc  8340
atgactctc  gattcttac  atcaggata  aactgaagg  caaaggatg  cttttgggt  8400
ttttaattt  tttaatatt  cactttata  tatttcata  gagacgatt  tcttaatta  8460
agccataaa  taccaataa  gcatatatt  agggcttct  gatatagtc  ataaacagt  8520
cacgggtca  tctgtgtgt  gttcgttgt  aaatgaagt  tatctgttc  gttttttat  8580
acttaaact  ctgttctag  caatcctaa  aaattgtag  tgtgtattt  aagcaaact  8640
tgaaaatca  agaaattat  cctttcatg  aagaattct  cattttcaa  gcaactcat  8700
gcatggttt  tttaagtag  aagttccac  attgcactg  aaatatttc  ttttacaga  8760
cctaagatt  tttttcagg  atccatttg  tatgttaag  aagattcgc  cacgtggag  8820
ttgaaatag  tgattagca  acatgcctg  aaaaattag  atgtgctta  gttcttaga  8880
ccatcatat  tttatataa  aacataagc  catcctaat  tttccaggc  tgtttgcta  8940
tc  8942



<210> 559
<211> 670
<212> PRT
<213> Rattus norvegicus
<308> O54701
<400> 559

Met Asp Leu His Gln Ser Ala Thr Val Arg Leu Leu Gln Glu Trp Cys 
  1               5                  10                  15
Ser His Glu Ser Pro Ser Gly Cys Arg Arg His Tyr Asn Thr Arg Lys 
             20                  25                  30
Lys Leu Lys Leu Ile Arg Val Ile Gly Leu Val Met Gly Leu Val Ala 
         35                  40                  45
Val Ser Thr Val Pro Phe Ser Ile Ser Ala Phe Thr Glu Thr Tyr Ser 
     50                  55                  60
Gln Asn Asn Arg Gly Glu Ala Ser Asp Val Thr Gly Pro Arg Ala Ala 
 65                  70                  75                  80
Pro Gly His Arg Gln Arg Thr Leu Leu Asp Leu Asn Asp Lys Ile Arg 
                 85                  90                  95
Asp Tyr Thr Pro Gln Pro Pro Ala Ser Gln Glu Asp Arg Ser Glu Asn 
             100                105                110
Gly Thr Asp His Ala Gln Gly Asp Tyr Pro Lys Asp Val Phe Ser Leu 
         115                120                125
Glu Glu Arg Arg Lys Gly Ala Ile Ile Leu His Val Ile Gly Met Ile 
     130                135                140
Tyr Met Phe Ile Ala Leu Ala Ile Val Cys Asp Glu Phe Phe Val Pro 
 145                150                155                160
Ser Leu Thr Val Ile Thr Glu Lys Leu Gly Ile Ser Asp Asp Val Ala 
                 165                170                175
Gly Ala Thr Phe Met Ala Ala Gly Gly Ser Ala Pro Glu Leu Phe Thr 
             180                185                190
Ser Leu Ile Gly Val Phe Ile Ala His Ser Asn Val Gly Ile Gly Thr 
         195                200                205
Ile Val Gly Ser Ala Val Phe Asn Ile Leu Phe Val Ile Gly Met Cys 
     210                215                220
Ala Leu Phe Ser Arg Glu Ile Leu Asn Leu Thr Trp Trp Pro Leu Phe 
 225                230                235                240
Arg Asp Val Ser Phe Tyr Ile Val Asp Leu Ile Met Leu Ile Ile Phe 
                 245                250                255
Phe Leu Asp Asn Val Ile Met Trp Trp Glu Ser Leu Leu Leu Leu Thr 
             260                265                270
Ala Tyr Phe Ala Tyr Val Val Phe Met Lys Phe Asn Val Gln Val Glu 
         275                280                285
Arg Trp Val Lys Gln Met Ile Asn Arg Asn Lys Val Val Lys Val Thr 
     290                295                300
Val Ser Glu Ala Gln Ala Lys Ala Ser Thr Ala Gly Asp Lys Glu Glu 
 305                310                315                320
Pro Thr Leu Pro Asn Lys Pro Arg Leu Gln Arg Gly Gly Ser Ser Ala 
                 325                330                335
Ser Leu His Asn Ser Leu Met Arg Asn Ser Ile Phe Gln Leu Met Ile 
             340                345                350
His Thr Leu Asp Pro Leu Ala Glu Glu Leu Gly Ser Tyr Gly Lys Leu 
         355                360                365
Lys Tyr Tyr Asp Thr Met Thr Glu Glu Gly Arg Phe Arg Glu Lys Ala 
     370                375                380
Ser Ile Leu His Lys Ile Ala Lys Lys Lys Cys Gln Val Asp Glu Asn 
 385                390                395                400
Glu Arg Gln Asn Gly Ala Ala Asn His Val Asp Tyr Ala Ala Glu Lys 
                 405                410                415
Ile Glu Leu Pro Asn Ser Thr Ser Thr Glu Val Glu Met Thr Pro Ser 
             420                425                430
Ser Glu Ala Ser Glu Pro Val Gln Asn Gly Asn Leu Ser His Ser Ile 
         435                440                445
Glu Ala Ala Asp Ala Pro Gln Ala Thr Glu Thr Ala Glu Glu Asp Asp 
     450                455                460
Asp Gln Pro Leu Ser Leu Ser Trp Pro Ser Asn Thr Arg Lys Gln Ile 
 465                470                475                480
Thr Phe Leu Ile Val Leu Pro Ile Val Phe Pro Leu Trp Ile Thr Leu 
                 485                490                495
Pro Asp Val Arg Lys Pro Ala Ser Lys Lys Phe Phe Pro Ile Thr Phe 
             500                505                510
Phe Gly Ser Ile Thr Trp Ile Ala Val Phe Ser Tyr Leu Met Val Trp 
         515                520                525
Trp Ala His Gln Val Gly Glu Thr Ile Gly Ile Ser Glu Glu Ile Met 
     530                535                540
Gly Leu Thr Ile Leu Ala Ala Gly Thr Ser Ile Pro Asp Leu Ile Thr 
 545                550                555                560
Ser Val Ile Val Ala Arg Lys Gly Leu Gly Asp Met Ala Val Ser Ser 
                 565                570                575
Ser Val Gly Ser Asn Ile Phe Asp Ile Thr Val Gly Leu Pro Leu Pro 
             580                585                590
Trp Leu Leu Tyr Thr Ile Ile His Arg Phe Lys Pro Val Thr Val Ser 
         595                600                605
Ser Asn Gly Leu Phe Cys Ala Ile Val Leu Leu Phe Ile Met Leu Ile 
     610                615                620
Phe Val Ile Leu Ser Ile Ala Leu Cys Lys Trp Arg Met Asn Lys Ile 
 625                630                635                640
Leu Gly Phe Ile Met Phe Gly Leu Tyr Phe Ala Phe Leu Val Val Ser 
                 645                650                655
Val Leu Leu Glu Asp Lys Val Leu Glu Cys Pro Val Ser Ile 
             660                665                670



<210> 560
<211> 2170
<212> DNA
<213> Homo sapiens
<308> AF177987
<400> 560

tgaaagaac  atctggttg  gtctaaagt  ggaagatca  catatccac  agaagaccc  60
ggatggatc  gcaacaaag  accaccatc  cttccctag  gaaatggtg  ttggatgag  120
cactgtctg  ctgcagaag  cattatagt  tcaagaaaa  actgaagtt  attcgagtc  180
taggccttt  catgggtct  gtagccatt  gcactgtct  attttcaat  agtgccttt  240
ctgagacag  tacacagag  acaggagag  ccagtgttg  aagtggccc  agggtagca  300
agggttacc  tcagagaac  ctcttagat  taaatgaca  gattctgga  tatactcca  360
agccacctc  ttctaagga  ggcgagtct  agaatagta  agatcacgc  caaggagac  420
acccgaaag  catcttttc  cttgaggag  gaagaaaag  tgcgatcat  ctgcatgtc  480
ttggaatga  ctacatgtt  atagcctta  ccattgtct  tgatgagtt  tttgttcct  540
ctttgactg  catcactga  aaactgggc  tctctgatg  tgtggctgg  gccaccttc  600
tggctgcag  agggtcagc  ccagaactt  tcacatctc  cataggggt  tttatcgct  660
acagcaacg  tggcatagg  acaattgta  gttcagcag  attcaacat  ctctttgtt  720
ttggcatgt  tgctctgtt  tctagagaa  tcttaaacc  gacatggtg  ccgctcttt  780
gagatgtgt  tttctacat  gttgacttg  tcatgctga  catattttt  ctggataat  840
tcatcatgt  gtgggaaag  ttgcttctc  taacagctt  tttttgcta  gtggttttc  900
tgaaattca  cgtccaagt  gaaaaatgg  tgaagcaaa  gataaaccg  aataaggtc  960
tcaaggtga  agcaccaga  gcccaagca  agccatctg  agccaggga  aaggatgaa  1020
cgactctac  ggctaagcc  cgtctccag  gaggtggaa  ctctgcctc  ctccacaac  1080
gtctcatga  gaatagcat  ttccaactc  tgatacaca  ccttgaccc  ctcgccgaa  1140
ggaggttca  agaaaaggc  tcaattctc  acaagatcg  caagaagaa  tgtcatgtg  1200
atgagaacg  gcggcagaa  ggggctgcc  accacgtgg  aaaaattga  cttccaaac  1260
gcaccagca  agatgttga  atgacacca  ccagtgatg  ttcagaacc  gtacaaaat  1320
gaaatctct  ccacaacat  gaaggtgca  aagcccaga  cgctgatga  gaggaggac  1380
agcctctca  ccttgcctg  ccttctgaa  cccgcaagc  agtcacgtt  ctgattgtt  1440
tccccatag  gtttcctct  tggattacg  tacctgacg  tcgcaaacc  tcatcgagg  1500
agttttttc  catcacgtt  tttggctcc  ttacctgga  tgcagtatt  tcttacttg  1560
tggtctggt  ggcgcacca  gttggagag  caattggca  cagtgaaga  attatgggc  1620
tgaccatct  ggctgctgg  acctccatc  ctgatctta  caccagtgt  atagtggcc  1680
ggaaggggt  aggggacat  gctgtgtcc  gctctgttg  aagcaacat  tttgacatc  1740
ctgtagggc  cccactgcc  tggctcctg  acaccgtca  tcacagatt  cagccagtg  1800
ctgtcagca  caatggcct  ttctgtgcc  tcgtccttc  cttcatcat  ctgctcttc  1860
tcatcctct  tatcgccct  tgcaagtgg  gaatgaaca  aatcctggg  ttcatcatg  1920
ttggcctct  ctttgtgtt  ctggtggtg  gcgttctcc  agaagacag  attcttaca  1980
gccccgtct  catctagca  gaaaagcca  atcttgcac  agcagcatg  atggtccct  2040
cacactctg  gctctgggc  ccttgacct  ttgagaaga  gcagctggc  cacagccct  2100
ggtgccaag  gtccctcct  ggtgaattt  aggagagat  gattcacac  gggcccatt  2160
acttcacagg  2170



<210> 561
<211> 661
<212> PRT
<213> Homo sapiens
<308> Q9UI40
<400> 561

Met Asp Leu Gln Gln Ser Thr Thr Ile Thr Ser Leu Glu Lys Trp Cys 
  1               5                  10                  15
Leu Asp Glu Ser Leu Ser Gly Cys Arg Arg His Tyr Ser Val Lys Lys 
             20                  25                  30
Lys Leu Lys Leu Ile Arg Val Leu Gly Leu Phe Met Gly Leu Val Ala 
         35                  40                  45
Ile Ser Thr Val Ser Phe Ser Ile Ser Ala Phe Ser Glu Thr Asp Thr 
     50                  55                  60
Gln Ser Thr Gly Glu Ala Ser Val Val Ser Gly Pro Arg Val Ala Gln 
 65                  70                  75                  80
Gly Tyr His Gln Arg Thr Leu Leu Asp Leu Asn Asp Lys Ile Leu Asp 
                 85                  90                  95
Tyr Thr Pro Gln Pro Pro Leu Ser Lys Glu Gly Glu Ser Glu Asn Ser 
             100                105                110
Thr Asp His Ala Gln Gly Asp Tyr Pro Lys Asp Ile Phe Ser Leu Glu 
         115                120                125
Glu Arg Arg Lys Gly Ala Ile Ile Leu His Val Ile Gly Met Ile Tyr 
     130                135                140
Met Phe Ile Ala Leu Ala Ile Val Cys Asp Glu Phe Phe Val Pro Ser 
 145                150                155                160
Leu Thr Val Ile Thr Glu Lys Leu Gly Ile Ser Asp Asp Val Ala Gly 
                 165                170                175
Ala Thr Phe Met Ala Ala Gly Gly Ser Ala Pro Glu Leu Phe Thr Ser 
             180                185                190
Leu Ile Gly Val Phe Ile Ala His Ser Asn Val Gly Ile Gly Thr Ile 
         195                200                205
Val Gly Ser Ala Val Phe Asn Ile Leu Phe Val Ile Gly Met Cys Ala 
     210                215                220
Leu Phe Ser Arg Glu Ile Leu Asn Leu Thr Trp Trp Pro Leu Phe Arg 
 225                230                235                240
Asp Val Ser Phe Tyr Ile Val Asp Leu Ile Met Leu Ile Ile Phe Phe 
                 245                250                255
Leu Asp Asn Val Ile Met Trp Trp Glu Ser Leu Leu Leu Leu Thr Ala 
             260                265                270
Tyr Phe Cys Tyr Val Val Phe Met Lys Phe Asn Val Gln Val Glu Lys 
         275                280                285
Trp Val Lys Gln Met Ile Asn Arg Asn Lys Val Val Lys Val Thr Ala 
     290                295                300
Pro Glu Ala Gln Ala Lys Pro Ser Ala Ala Arg Asp Lys Asp Glu Pro 
 305                310                315                320
Thr Leu Pro Ala Lys Pro Arg Leu Gln Arg Gly Gly Ser Ser Ala Ser 
                 325                330                335
Leu His Asn Ser Leu Met Arg Asn Ser Ile Phe Gln Leu Met Ile His 
             340                345                350
Thr Leu Asp Pro Leu Ala Glu Glu Leu Gly Ser Tyr Gly Lys Leu Lys 
         355                360                365
Tyr Tyr Asp Thr Met Thr Glu Glu Gly Arg Phe Arg Glu Lys Ala Ser 
     370                375                380
Ile Leu His Lys Ile Ala Lys Lys Lys Cys His Val Asp Glu Asn Glu 
 385                390                395                400
Arg Gln Asn Gly Ala Ala Asn His Val Glu Lys Ile Glu Leu Pro Asn 
                 405                410                415
Ser Thr Ser Thr Asp Val Glu Met Thr Pro Ser Ser Asp Ala Ser Glu 
             420                425                430
Pro Val Gln Asn Gly Asn Leu Ser His Asn Ile Glu Gly Ala Glu Ala 
         435                440                445
Gln Thr Ala Asp Glu Glu Glu Asp Gln Pro Leu Ser Leu Ala Trp Pro 
     450                455                460
Ser Glu Thr Arg Lys Gln Val Thr Phe Leu Ile Val Phe Pro Ile Val 
 465                470                475                480
Phe Pro Leu Trp Ile Thr Leu Pro Asp Val Arg Lys Pro Ser Ser Arg 
                 485                490                495
Lys Phe Phe Pro Ile Thr Phe Phe Gly Ser Ile Thr Trp Ile Ala Val 
             500                505                510
Phe Ser Tyr Leu Met Val Trp Trp Ala His Gln Val Gly Glu Thr Ile 
         515                520                525
Gly Ile Ser Glu Glu Ile Met Gly Leu Thr Ile Leu Ala Ala Gly Thr 
     530                535                540
Ser Ile Pro Asp Leu Ile Thr Ser Val Ile Val Ala Arg Lys Gly Leu 
 545                550                555                560
Gly Asp Met Ala Val Ser Ser Ser Val Gly Ser Asn Ile Phe Asp Ile 
                 565                570                575
Thr Val Gly Leu Pro Leu Pro Trp Leu Leu Tyr Thr Val Ile His Arg 
             580                585                590
Phe Gln Pro Val Ala Val Ser Ser Asn Gly Leu Phe Cys Ala Ile Val 
         595                600                605
Leu Leu Phe Ile Met Leu Leu Phe Val Ile Leu Ser Ile Ala Leu Cys 
     610                615                620
Lys Trp Arg Met Asn Lys Ile Leu Gly Phe Ile Met Phe Gly Leu Tyr 
 625                630                635                640
Phe Val Phe Leu Val Val Ser Val Leu Leu Glu Asp Arg Ile Leu Thr 
                 645                650                655
Cys Pro Val Ser Ile 
             660



<210> 562
<211> 1307
<212> DNA
<213> Rattus norvegicus
<308> AF022742
<400> 562

ccctgatct  tgaaccata  aacacttgc  cgacattct  aagcaacta  ataggtctg  60
ccttggcga  gcctgccca  gatcagggg  ttgctgtcc  gatgtcaga  tggagaaga  120
tggagaagg  tttgaggtt  ttagaccac  ccatcctct  gctgcccta  tataatttc  180
ggcctcttc  aaggtcatt  gggacccaa  ccctctgct  gtcacagca  ccaggcttc  240
tgagctccc  tcagggatc  agctaatcc  tctcagagt  ttgcaagtt  cagacacac  300
ctctaccag  ctcttcctt  ttttccccc  tgccccaac  accaggcca  cctccaaac  360
ctggtagca  ctataggga  gtgtgtgtg  acgtgtgcg  ttgcttgtg  acgtgtgta  420
aggtttaaa  acaggctac  cgtgggcta  accggagag  ctgggacgg  aactgtcga  480
ttgctgaca  aattcagtt  tgtggtggc  cctgcaggc  acgccctag  gcctcccta  540
gcccggaca  tgtttttaa  tcttcgcac  gaggtgatc  caggctgga  ggcgggcac  600
aggcgtccg  agaacccag  aatccgaga  cgcagcatc  gcccttccc  ctaggcact  660
ccttccttt  cccgaacct  cagagaggg  gggccgcgc  tttataaac  ggagcctca  720
ctgagtggc  tgtcagagg  tgcctcgca  ggactacga  cctgggcta  aaaagtcta  780
gctgagaca  aggctaact  ctgtcgccg  agacgtacg  accctctgc  gggactggg  840
gcctgcacc  tcgcagtgc  agcgtttct  gtagcttgc  cggtgttct  ctgaacagc  900
tgcttgggg  tttccttct  ggtgtgctg  ctccagctg  cctggggat  tctgcacta  960
ccaagctgc  gcccaaagg  agtcaatgc  tggggaatg  gtgcttcgc  cttttccag  1020
accccgtga  cttcctcga  gccagccag  cctgccagc  cctgcaggg  catttgatg  1080
cagtgcgct  ctcggtggc  gcggatgtc  tctcccttc  ggtgagcga  agtagtatg  1140
actcacggc  ctggatcgg  ttacagctc  ctcagggct  tggtgaccc  gtgcatctc  1200
ggcccctgc  cggcttcca  tgggttact  gggataacc  caccagtta  agcaggtgg  1260
cgcggccca  cgaccagtc  cctccactt  gcggtccgc  gtgcgtc  1307



<210> 563
<211> 577
<212> PRT
<213> Rattus norvegicus
<308> AAB80923
<400> 563

Met Leu Gly Val Phe Leu Leu Gly Val Leu Ala Pro Ala Gly Leu Gly 
  1               5                  10                  15
Ile Ser Ala Leu Ala Lys Leu Gln Pro Lys Gly Ser Gln Cys Val Gly 
             20                  25                  30
Asn Glu Cys Phe Ala Leu Phe Gln Asp Pro Val Thr Phe Leu Asp Ala 
         35                  40                  45
Ser Gln Ala Cys Gln Arg Leu Gln Gly His Leu Met Thr Val Arg Ser 
     50                  55                  60
Ser Val Ala Ala Asp Val Ile Ser Leu Leu Val Ser Asp Ser Ser Met 
 65                  70                  75                  80
Asp Ser Arg Pro Trp Ile Gly Leu Gln Leu Pro Gln Gly Cys Gly Asp 
                 85                  90                  95
Pro Val His Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr Gly Asp 
             100                105                110
Asn His Thr Ser Tyr Ser Arg Trp Ala Arg Pro Asn Asp Gln Ser Pro 
         115                120                125
Pro Leu Cys Gly Pro Leu Cys Val Thr Val Ser Thr Ala Thr Glu Ala 
     130                135                140
Ala Pro Gly Glu Pro Ala Trp Glu Glu Lys Pro Cys Glu Asn Glu Thr 
 145                150                155                160
Lys Gly Phe Leu Cys Glu Phe Tyr Phe Ala Ala Phe Cys Arg Pro Leu 
                 165                170                175
Arg Val Asn Thr Arg Asp Pro Glu Gly Ala His Ile Ser Ser Thr Tyr 
             180                185                190
Asn Thr Pro Leu Gly Val Ser Gly Ala Asp Phe Gln Thr Leu Pro Ile 
         195                200                205
Gly Ser Ser Ala Thr Val Ala Pro Phe Gly Leu Glu Leu Val Cys Arg 
     210                215                220
Ala Leu Pro Gly Thr Ser Glu Gly His Trp Thr Arg Glu Val Thr Gly 
 225                230                235                240
Ala Trp Asn Cys Ser Val Glu Asn Gly Gly Cys Glu Tyr Met Cys Asn 
                 245                250                255
Arg Ser Ala Asn Gly Pro Arg Cys Val Cys Pro Ser Gly Gly Asp Leu 
             260                265                270
Gln Ala Asp Gly Arg Ser Cys Ala Lys Pro Val Ala Gln Leu Cys Asn 
         275                280                285
Glu Leu Cys Gln His Phe Cys Val Asn Asn Ser Asp Val Pro Gly Ser 
     290                295                300
Tyr Ser Cys Met Cys Glu Thr Gly Tyr Gln Leu Ala Ala Asp Gly His 
 305                310                315                320
Arg Cys Glu Asp Val Asp Asp Cys Lys Gln Gly Pro Asn Pro Cys Pro 
                 325                330                335
Gln Leu Cys Ser Asn Thr Glu Gly Gly Phe Glu Cys Arg Cys Tyr Asp 
             340                345                350
Gly Tyr Glu Leu Val Asp Gly Glu Cys Val Glu Gln Leu Asp Pro Cys 
         355                360                365
Phe Arg Ser Lys Cys Glu Tyr Gln Cys Gln Pro Val Asn Ser Thr His 
     370                375                380
Tyr Asn Cys Ile Cys Ala Glu Gly Phe Ala Pro Lys Leu Asp Asp Pro 
 385                390                395                400
Asp Arg Cys Glu Met Phe Cys Asn Glu Thr Ser Cys Pro Ala Asp Cys 
                 405                410                415
Asp Pro Asn Ser Pro Ser Phe Cys Gln Cys Pro Glu Gly Phe Ile Leu 
             420                425                430
Asp Glu Gly Ser Ile Cys Thr Asp Ile Asp Glu Cys Ser Gln Gly Glu 
         435                440                445
Cys Leu Thr Asn Glu Cys Arg Asn Leu Pro Gly Ser Tyr Glu Cys Ile 
     450                455                460
Cys Gly Pro Asp Thr Ala Leu Ala Gly Gln Ile Ser Lys Asp Cys Asp 
 465                470                475                480
Pro Ile Pro Val Leu Glu Asp Ser Glu Asp Gly Gly Ser Gly Glu His 
                 485                490                495
Pro Ser Ser Asn Pro Thr Val Val Ser Ser Thr Val Pro Pro Ser Ala 
             500                505                510
Arg Pro Met His Ser Gly Val Leu Ile Gly Ile Ser Ile Ala Ser Leu 
         515                520                525
Ser Leu Val Val Ala Leu Leu Ala Leu Leu Cys His Leu Arg Lys Lys 
     530                535                540
Gln Gly Thr Ala Arg Ala Glu Leu Glu Tyr Lys Cys Thr Ser Ser Ala 
 545                550                555                560
Lys Glu Val Val Leu Gln His Val Arg Thr Asp Arg Thr Leu Gln Lys 
                 565                570                575
Phe 
             580



<210> 564
<211> 3466
<212> DNA
<213> Homo sapiens
<308> X05495
<400> 564

caggggctg  gcgcagcgg  aagaagtgt  tgggctggg  cggacagga  aggctgtcg  60
catcggcgt  ctgtgcccc  ctgctccgg  acggccctg  cgcagtgcc  gcgctttcc  120
cggcgcctg  acgcggcgc  cctgggtaa  atgcttggg  tcctggtcc  tggcgcgct  180
gccctggcc  gcctggggt  ccccgcacc  gcagagccg  agccgggtg  cagccagtg  240
gtcgagcac  actgcttcg  gctctaccc  ggccccgcg  ccttcctca  tgccagtca  300
atctgcgac  gactgcggg  ccacctaat  acagtgcgc  cctcggtgg  tgccgatgt  360
atttccttg  tactgaacg  cgacggcgg  gttggccgc  ggcgcctct  gatcggcct  420
cagctgcca  ccggctgcg  cgaccccaa  cgcctcggg  ccctgcgcg  cttccagtg  480
gttacggga  acaacaaca  cagctatag  aggtgggca  ggctcgacc  caatggggc  540
cccctctgc  gcccgttgt  cgtcgctgt  tccgctgct  aggccactg  gcccagcga  600
ccgatctgg  aggagcagc  gtgcgaagt  aaggccgat  gcttcctct  cgagttcca  660
ttcccagcc  cctgcaggc  actggctgt  gagcccggc  ccgcggctg  cgccgtctc  720
atcacctac  gcaccccgt  cgcggcccg  ggagcggac  tccaggcgc  gccggtggg  780
agctccgcc  cggtggctc  cctcggctt  cagctaatg  gcaccgcgc  gcccggagc  840
gtccagggg  actgggcca  ggaggcgcc  ggcgcttgg  actgcagcg  ggagaacgg  900
ggctgcgag  acgcgtgca  tgcgatccc  ggggctccc  gctgccagt  cccagccgg  960
gccgccctg  aggcagacg  gcgctcctg  accgcatcc  cgacgcagt  ctgcaacga  1020
ctctgcgag  acttctgcg  tcccaaccc  gaccagccg  gctcctact  gtgcatgtg  1080
gagaccggc  accggctgg  ggccgacca  caccggtgc  aggacgtgg  tgactgcat  1140
ctggagccc  gtccgtgtc  gcagcgctg  gtcaacaca  agggtggct  cgagtgcca  1200
tgctaccct  actacgacc  ggtggacgg  gagtgtgtg  agcccgtgg  cccgtgctt  1260
agagccaac  gcgagtacc  gtgccagcc  ctgaaccaa  ctagctacc  ctgcgtctg  1320
gccgagggc  tcgcgccca  tccccacga  ccgcacagg  gccagatgt  ttgcaacca  1380
actgcctgt  cagccgact  cgaccccaa  acccaggct  gctgtgagt  ccctgaagg  1440
tacatcctg  acgacggtt  catctgcac  gacatcgac  agtgcgaaa  cggcggctt  1500
tgctccggg  tgtgccaca  cctccccgg  accttcgag  gcatctgcg  gcccgactc  1560
gcccttgtc  gccacattg  caccgactg  gactccggc  aggtggacg  tggcgacag  1620
ggctctggc  agcccccgc  cagcccgac  cccggctcc  ccttgactc  tccggccgt  1680
gggctcgtg  attcgggct  gctcatagg  atctccatc  cgagcctgt  cctggtggt  1740
gcgcttttg  cgctcctct  ccacctgcg  aagaagcag  gcgccgcca  ggccaagat  1800
gagtacaag  gcgcggccc  ttccaagga  gtagtgctg  agcacgtgc  gaccgagcg  1860
acgccgcag  gactctgag  ggcctccgt  caggagcct  gctccgtcc  ggagcctgt  1920
cctcctcac  cccagcttt  ctaccaaag  accttagct  gcattacag  tggagaaga  1980
cctccccgc  ccccccaag  tgttttctt  tattccatg  ctaactggc  agggggtga  2040
tagagggag  agaatgagc  tcggcctct  ccgtgacgt  actggacca  tgggcaatg  2100
tggcaattt  gtaacgaag  cacagactg  gatttgtcc  aggtcctca  taccgggcg  2160
aggagggtg  gcgttattg  tcggcagcc  tctgggcag  ccttgacct  gtgggctag  2220
gatgactaa  atatttatt  tttttaagt  tttaggttt  tgtttgttt  ctttgttct  2280
acctgtatg  ctccagtat  cactttgca  agctctccg  tctctctct  tctacaaac  2340
cccacttgt  atgtgacag  taaactatc  tggtgaatt  ttttttcct  gccctctca  2400
atttatgaa  caagcccca  ttattcccc  ttcttccta  ttttctcct  ccaggaact  2460
ggccaactc  cctgagtca  cctacctgt  cctgaccct  cttcttttg  tcttagctg  2520
ctgctcaga  agaacccct  catgaaaca  aaacaaaaa  actaaaaat  aaaatggcc  2580
tttgctttt  caccagatt  gctaattta  cctgaaatt  cagattccc  gagcaaaat  2640
attttaaac  aaggttgag  tgtaaaagg  attaaattg  tgttgctgg  ctgtcatag  2700
aattacacc  aaagaggta  ttatcttta  ttttaaaca  tgagcctga  ttttgttgc  2760
gttttgatt  gtactgaaa  atggtaatt  ttgctaatc  tcttatgca  tttcctttt  2820
tgttattat  acttatttt  gacagtgtt  aaaatgttc  gaaggttgc  ctagattgc  2880
agaagagac  aacacctcc  aggagacag  tcaagaaag  ttcaaactg  atgattcat  2940
ccaattagc  attgactgt  actgttcct  gtcactggt  gaccaaaat  aaaccgact  3000
tactggtct  gtggaattg  gagcttggg  atggatcct  gaggatgcc  aattagggc  3060
tagccttaa  caggtcctc  gagaatttc  accatttca  agaggcctt  tggaatgtg  3120
cccctgaac  agaattgga  gctgccctg  ccatgggag  tggttagaa  tgcagaatc  3180
taggctcca  cccatccag  tcatgagaa  ctatattta  caagatctg  agggggtgt  3240
tctgctcag  aatttgagg  caaccattc  agactgctt  caattttct  gaatacatg  3300
aatatagat  agttataag  agcaggcca  gtcaggccc  tattttcaa  aaactgagg  3360
attttcttt  tgtagcttt  ctctttggt  gaaaaggct  ggtacacag  tctagacac  3420
gccacacag  gtctgcaag  tctttggtt  agctaagcc  gaattc  3466



<210> 565
<211> 575
<212> PRT
<213> Homo sapiens
<308> P07204
<400> 565

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
  1               5                  10                  15
Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu 
             20                  25                  30
His Asp Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala 
         35                  40                  45
Ser Gln Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser 
     50                  55                  60
Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly 
 65                  70                  75                  80
Val Gly Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys 
                 85                  90                  95
Gly Asp Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr 
             100                105                110
Gly Asp Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn 
         115                120                125
Gly Ala Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu 
     130                135                140
Ala Thr Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val 
 145                150                155                160
Lys Ala Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg 
                 165                170                175
Pro Leu Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr 
             180                185                190
Tyr Gly Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro 
         195                200                205
Val Gly Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys 
     210                215                220
Thr Ala Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro 
 225                230                235                240
Gly Ala Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys 
                 245                250                255
Asn Ala Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala 
             260                265                270
Leu Gln Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys 
         275                280                285
Asn Asp Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly 
     290                295                300
Ser Tyr Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln 
 305                310                315                320
His Arg Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys 
                 325                330                335
Pro Gln Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr 
             340                345                350
Pro Asn Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro 
         355                360                365
Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr 
     370                375                380
Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu 
 385                390                395                400
Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp 
                 405                410                415
Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile 
             420                425                430
Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly 
         435                440                445
Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
     450                455                460
Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys 
 465                470                475                480
Asp Ser Gly Lys Val Asp Gly Gly Asp Ser Gly Ser Gly Glu Pro Pro 
                 485                490                495
Pro Ser Pro Thr Pro Gly Ser Thr Leu Thr Pro Pro Ala Val Gly Leu 
             500                505                510
Val His Ser Gly Leu Leu Ile Gly Ile Ser Ile Ala Ser Leu Cys Leu 
         515                520                525
Val Val Ala Leu Leu Ala Leu Leu Cys His Leu Arg Lys Lys Gln Gly 
     530                535                540
Ala Ala Arg Ala Lys Met Glu Tyr Lys Cys Ala Ala Pro Ser Lys Glu 
 545                550                555                560
Val Val Leu Gln His Val Arg Thr Glu Arg Thr Pro Gln Arg Leu 
                 565                570                575



<210> 566
<211> 1582
<212> DNA
<213> Rattus norvegicus
<308> AF022819
<400> 566

gaaagggag  ggcggcggg  ggcgcggag  gcgggcgcc  ggaagatgc  gcagtccct  60
gccggcagc  cgtgcgtgc  cctggtgga  cggcaccgc  cggcctggt  cttcggctt  120
ctggtgctg  gctacctgc  ctacctggt  ttcggcgcc  tggtcttct  gtccgtgga  180
ctgccttat  aggacctgc  gcgccagga  ctgcgcaag  tgaagcggc  cttcctgga  240
gagcacgag  gcctgtcgg  gccccagct  gagcagttc  tgggccgcg  gctggaggc  300
agcaattat  gagtgtcgg  gctcagcaa  gcctcgggg  attggaatt  ggacttcac  360
tcggcgctc  tcttcgcca  cacggtgct  tccaccaca  gctatggcc  cacggtgcc  420
ttgtcagat  ggggcaagg  cttctgcat  atctactct  tcattggca  cccgttcac  480
ctcctcttc  tgacggccg  ggtccagcg  gtcaccgtg  atgtcaccc  cagaccggt  540
ctctacttc  acatacgct  gggcttctc  aagcaggtg  tggccatcg  ccatgccgt  600
ctgctggga  tcgtcaccg  gtcctgctt  ttcttcatc  cggccgccg  gttctccgt  660
ctggaggat  actggaact  cctcgaatc  ttttacttc  gtttcatct  cctgagcac  720
atcggcctg  gggactacg  tccagggga  ggctacaac  agaagttcc  ggagctgta  780
aagatcggg  tcacgtgtt  cctgctcct  ggactcata  ccatgctgg  tgtcctgga  840
accttctgt  agctccacg  gctgaagaa  ttcaggaaa  tgttctatg  gaagaaaga  900
aaggatgaa  accaagttc  catcatgga  catgaccaa  tgtcctttt  ctccatcac  960
gagcaggcg  ccggcctga  ggaggagca  aagcaaaac  agccttttg  ggcctccca  1020
tcaccaccc  atgaggatg  ctctgcaaa  cattgagca  gggtcacca  accccggac  1080
tgaggcaga  cctagactg  gttcatttt  acgagaaag  caaagctaa  atgatgtta  1140
tttaagaaa  atctactgt  aacaatatt  taaaaacac  gaactttgg  tcctggggg  1200
gtgggtttt  atctctggg  aaatgaggt  tgcacccat  actcacagg  aatgtgatc  1260
cctgacatc  tgcagctgt  actcacagg  gatgtcatc  cctggcatc  tgcacctgt  1320
actcacagg  gatgtcatc  cctggcatc  tgcacctgt  actcacagg  gatattatc  1380
cctggcatc  tgcacctgt  actcacagg  gatgtcatc  cctggcatc  tgcacttgt  1440
actcacagg  tgatgtcat  gcctggcat  ctgcacctg  aactccaca  ttgatgtca  1500
cacctgggc  ttacacact  gggaagaaa  acttgaaac  tgttactgc  ccggaaatc  1560
cattctaaa  ccaaactta  ta  1582



<210> 567
<211> 336
<212> PRT
<213> Rattus norvegicus
<308> AAD09336
<400> 567

Met Leu Gln Ser Leu Ala Gly Ser Ser Cys Val Arg Leu Val Glu Arg 
  1               5                  10                  15
His Arg Ser Ala Trp Cys Phe Gly Phe Leu Val Leu Gly Tyr Leu Leu 
             20                  25                  30
Tyr Leu Val Phe Gly Ala Val Val Phe Ser Ser Val Glu Leu Pro Tyr 
         35                  40                  45
Glu Asp Leu Leu Arg Gln Glu Leu Arg Lys Leu Lys Arg Arg Phe Leu 
     50                  55                  60
Glu Glu His Glu Cys Leu Ser Glu Pro Gln Leu Glu Gln Phe Leu Gly 
 65                  70                  75                  80
Arg Val Leu Glu Ala Ser Asn Tyr Gly Val Ser Val Leu Ser Asn Ala 
                 85                  90                  95
Ser Gly Asn Trp Asn Trp Asp Phe Thr Ser Ala Leu Phe Phe Ala Ser 
             100                105                110
Thr Val Leu Ser Thr Thr Gly Tyr Gly His Thr Val Pro Leu Ser Asp 
         115                120                125
Gly Gly Lys Ala Phe Cys Ile Ile Tyr Ser Val Ile Gly Ile Pro Phe 
     130                135                140
Thr Leu Leu Phe Leu Thr Ala Val Val Gln Arg Val Thr Val His Val 
 145                150                155                160
Thr Arg Arg Pro Val Leu Tyr Phe His Ile Arg Trp Gly Phe Ser Lys 
                 165                170                175
Gln Val Val Ala Ile Val His Ala Val Leu Leu Gly Phe Val Thr Val 
             180                185                190
Ser Cys Phe Phe Phe Ile Pro Ala Ala Val Phe Ser Val Leu Glu Asp 
         195                200                205
Asp Trp Asn Phe Leu Glu Ser Phe Tyr Phe Cys Phe Ile Ser Leu Ser 
     210                215                220
Thr Ile Gly Leu Gly Asp Tyr Val Pro Gly Glu Gly Tyr Asn Gln Lys 
 225                230                235                240
Phe Arg Glu Leu Tyr Lys Ile Gly Ile Thr Cys Tyr Leu Leu Leu Gly 
                 245                250                255
Leu Ile Ala Met Leu Val Val Leu Glu Thr Phe Cys Glu Leu His Glu 
             260                265                270
Leu Lys Lys Phe Arg Lys Met Phe Tyr Val Lys Lys Asp Lys Asp Glu 
         275                280                285
Asp Gln Val His Ile Met Glu His Asp Gln Leu Ser Phe Ser Ser Ile 
     290                295                300
Thr Glu Gln Ala Ala Gly Leu Lys Glu Glu Gln Lys Gln Asn Glu Pro 
 305                310                315                320
Phe Val Ala Ser Gln Ser Pro Pro Tyr Glu Asp Gly Ser Ala Asn His 
                 325                330                335



<210> 568
<211> 1882
<212> DNA
<213> Homo sapiens
<308> U33632
<400> 568

gggcaggaa  acggcgctg  ccggaggag  ggggcgggc  ggcgcgcgg  ggagcgggc  60
gcgggcggg  gccaggccc  ggcgggggc  ggggcggcg  ggccagaag  ggcggcggg  120
cgcgctccg  ccggtctgc  gcgttggcc  tggctttgg  tttggcggc  gcggtggag  180
agatgctgc  gtccctggc  ggcagctcg  gcgtgcgcc  ggtggagcg  caccgctcg  240
cctggtgct  cggcttcct  gtgctgggc  acttgctct  cctggtctt  ggcgcagtg  300
tcttctcct  ggtggagct  ccctatgag  acctgctgc  ccaggagct  cgcaagctg  360
agcgacgct  cttggagga  cacgagtgc  tgtctgagc  gcagctgga  cagttcctg  420
gccgggtgc  ggaggccag  aactacggc  tgtcggtgc  cagcaacgc  tcgggcaac  480
ggaactggg  cttcacctc  gcgctcttc  tcgccagca  cgtgctctc  accacaggt  540
atggccaca  cgtgccctt  tcagatgga  gtaaggcct  ctgcatcat  tactccgtc  600
ttggcattc  cttcaccct  ctgttcctg  cggctgtgg  ccagcgcat  accgtgcac  660
tcacccgca  gccggtcct  tacttccac  tccgctggg  cttctccaa  caggtggtg  720
ccatcgtcc  tgccgtgct  cttgggttt  tcactgtgt  ctgcttctt  ttcatcccg  780
ccgctgtct  ctcagtcct  gaggatgac  ggaacttcc  ggaatcctt  tatttttgt  840
ttatttccc  gagcaccat  ggcctgggg  attatgtgc  tggggaagg  tacaatcaa  900
aattcagag  gctctataa  attgggatc  cgtgttacc  gctacttgg  cttattgcc  960
tgttggtag  tctggaaac  ttctgtgaa  tccatgagc  gaaaaaatt  agaaaaatg  1020
tctatgtga  gaaggacaa  gacgaggat  aggtgcaca  catagagca  gaccaactg  1080
ccttctcct  gatcacaga  caggcagct  gcatgaaag  ggaccagaa  caaaatgag  1140
cttttgtgg  cacccagtc  tctgcctgc  tggatggcc  tgcaaacca  tgagcgtag  1200
atttgttgc  ttatgctag  gcaccaggg  cagggtgca  ggaagaggc  taagtatgt  1260
catttttat  agaatgcaa  agcgaaaat  atgtcactt  aagaaatag  tactgtttg  1320
aatgtctta  taaaaaaca  caaaaaaag  cacatggaa  aaagaagct  tgaccccag  1380
aggatgtct  atatgtgag  aaatgagat  tccacctaa  attcatatg  gacaaaatt  1440
tctcgacct  acataggag  agaatactt  aagcagtat  ctgctgtgg  tagaagcag  1500
ttttatact  ttaactgga  actttgggg  ttgcattta  atcatttag  tgatggcta  1560
atagcaaaa  ttatattta  aagcaaaaa  aaaaagcat  gagatgtgt  ttataaata  1620
gtttatgtg  actggtttg  atgtaccca  ccaaaatga  tatttttgg  gaatctaag  1680
caaactcac  atttataat  cataggtaa  cattaacta  gtacatata  agtataaat  1740
tgtttatat  ctgtacata  ggtttaggt  accagatcc  agtgtagtt  tgaaactaa  1800
actatagat  ttttgtttc  tttgatttc  ctttatact  aagaatcca  agttgctac  1860
ataaaataa  gggaataat  aa  1882



<210> 569
<211> 336
<212> PRT
<213> Homo sapiens
<308> O00180
<400> 569

Met Leu Gln Ser Leu Ala Gly Ser Ser Cys Val Arg Leu Val Glu Arg 
  1               5                  10                  15
His Arg Ser Ala Trp Cys Phe Gly Phe Leu Val Leu Gly Tyr Leu Leu 
             20                  25                  30
Tyr Leu Val Phe Gly Ala Val Val Phe Ser Ser Val Glu Leu Pro Tyr 
         35                  40                  45
Glu Asp Leu Leu Arg Gln Glu Leu Arg Lys Leu Lys Arg Arg Phe Leu 
     50                  55                  60
Glu Glu His Glu Cys Leu Ser Glu Gln Gln Leu Glu Gln Phe Leu Gly 
 65                  70                  75                  80
Arg Val Leu Glu Ala Ser Asn Tyr Gly Val Ser Val Leu Ser Asn Ala 
                 85                  90                  95
Ser Gly Asn Trp Asn Trp Asp Phe Thr Ser Ala Leu Phe Phe Ala Ser 
             100                105                110
Thr Val Leu Ser Thr Thr Gly Tyr Gly His Thr Val Pro Leu Ser Asp 
         115                120                125
Gly Gly Lys Ala Phe Cys Ile Ile Tyr Ser Val Ile Gly Ile Pro Phe 
     130                135                140
Thr Leu Leu Phe Leu Thr Ala Val Val Gln Arg Ile Thr Val His Val 
 145                150                155                160
Thr Arg Arg Pro Val Leu Tyr Phe His Ile Arg Trp Gly Phe Ser Lys 
                 165                170                175
Gln Val Val Ala Ile Val His Ala Val Leu Leu Gly Phe Val Thr Val 
             180                185                190
Ser Cys Phe Phe Phe Ile Pro Ala Ala Val Phe Ser Val Leu Glu Asp 
         195                200                205
Asp Trp Asn Phe Leu Glu Ser Phe Tyr Phe Cys Phe Ile Ser Leu Ser 
     210                215                220
Thr Ile Gly Leu Gly Asp Tyr Val Pro Gly Glu Gly Tyr Asn Gln Lys 
 225                230                235                240
Phe Arg Glu Leu Tyr Lys Ile Gly Ile Thr Cys Tyr Leu Leu Leu Gly 
                 245                250                255
Leu Ile Ala Met Leu Val Val Leu Glu Thr Phe Cys Glu Leu His Glu 
             260                265                270
Leu Lys Lys Phe Arg Lys Met Phe Tyr Val Lys Lys Asp Lys Asp Glu 
         275                280                285
Asp Gln Val His Ile Ile Glu His Asp Gln Leu Ser Phe Ser Ser Ile 
     290                295                300
Thr Asp Gln Ala Ala Gly Met Lys Glu Asp Gln Lys Gln Asn Glu Pro 
 305                310                315                320
Phe Val Ala Thr Gln Ser Ser Ala Cys Val Asp Gly Pro Ala Asn His 
                 325                330                335



<210> 570
<211> 2552
<212> DNA
<213> Rattus norvegicus
<308> AF023657
<400> 570

cgggttttg  tgagggcat  catacagcc  tcctaaagg  aatgctctc  acagggttt  60
agatacctc  gtcggggcc  ggaaaaaca  gggagcctt  atggcaaca  attcagagg  120
gatgatggg  tgttccagt  tgggtagat  cttctcatc  acactctct  cgatcatca  180
cttggtggc  acatcaatg  agtccaccc  aagagtctt  gaaaacaaa  ccgacttcc  240
aaggagtga  cgaatcgac  tggaaacaa  caccaagga  ttgaaaggg  ctggtgtga  300
tgtgcaccc  cccagagcc  ctgaggtga  cctggaaga  ctgcctcca  tgaactatt  360
tgtacatgc  ttttattac  gttggtatg  aaacccaca  ttcgatggt  aatacgtac  420
ctggaacca  ccagtcctg  aacactggg  ccctagaat  gccaagaac  atccccaag  480
aagacatag  cctccagat  acattggct  cagttttta  cctgagtta  gaagttaca  540
ctcccgaga  ccttctgtc  tagaaactc  catgaaaca  atgcgctca  cctccattg  600
agtactggc  ctgtcttgg  acccacctg  tgcaagtga  gagaatgga  aagctactg  660
ttacttggt  ccaactatt  tggataaag  tcataaata  aatctgaag  tcacttttc  720
catagaacc  tatagcaat  gagatgacc  aaacatgca  caaaatgtg  agtatatta  780
agacaagta  ggaaaccat  cagcctttt  taggtacaa  accaggatg  ggcattctc  840
acccatgtt  tatatctat  attcttata  cacaaagcc  aaaacatgg  ccaatctat  900
aacaccctc  ggatctcag  gtgttcgcg  ttctcctta  gatggcttg  ttattgcac  960
tctagtaga  gaaaagcat  aatacgata  tcttcaaag  gggtttgat  gaatttaca  1020
atattttgc  acaaatggc  ttacatatg  ctcatctca  cagaattgg  ataaactga  1080
atcattttg  gaaaagaac  acatgatat  tatcccaag  gttggccca  gatacatag  1140
tacaagcat  cgtccatgg  acactcaga  cacccggaa  agaatcaat  ggaaatatt  1200
tgaagttgg  ctaagcgct  cactccaga  ccagcccag  ttaatctcc  tcacctctt  1260
caatgaatg  catgaaggg  ctcaaatcg  aaaggctgt  cccaaaaga  ctgctaaca  1320
ggtatacct  gattaccgg  ctcataagc  aagtcttta  ctagaaata  ctcgaaaat  1380
gtctgaaaa  tacagtaag  aaagaatga  gtatgcatt  gatcaacag  tgcctgctt  1440
ataatgtac  tcttatagt  tgtcaagac  cctagcttc  gtcaacaca  tatattatg  1500
gctatgaaa  ctgtcaaaa  caatgtgtg  ttgctactg  aacctttat  agttatttc  1560
tttttactt  ttaaaagat  catttttct  caatggaca  taccttaca  aaacatcta  1620
caagataag  tctgtcagt  acattcctg  tggtatagt  ttctgaatt  cggactatt  1680
ttgaaatct  aatggagtt  ccttgtttt  gtttcccat  aagaaaatg  ttgtattac  1740
ttacaaaaa  cagctaaca  ctaatgttc  ggtaagtca  acttgtatt  tgggtccaa  1800
gacatagga  tatgtacat  ttaggtaca  ctggcaaca  aaagttcag  cctaaagga  1860
agtaagtga  tgtgcttca  ttctggact  tttggtgaa  tttgttaat  ttcagagtc  1920
ggttggctt  ccctggtga  ccagctcac  tttcaagtt  gttgtgaac  cagacctgt  1980
taagtaaaa  gtcctttta  cacattttt  tgtttctgt  agccatggt  tgttgaaga  2040
tgcctgtgt  ggcatccat  agtgtcagt  ttcgaagac  cgggtgcct  tggtgctaa  2100
tgcttttgc  tgttgaatg  tcctggatt  tcctgctga  ctaaaaact  gaaacaata  2160
gtagtttgt  aaatgttca  gactgtttc  aatatatga  aaaaataat  gtttaagaa  2220
ggttaaaat  taatgttca  cagagacta  tgaacggac  ttgaaagga  aatgtttaa  2280
actccaaat  gttttccct  caatatttt  atttaattt  actgtaata  agaaaattt  2340
catatcact  caaaaatag  gatactttt  aagtaacat  atgtatttc  gtaatgtcc  2400
ccactttaa  gtcttaccc  tatatagtg  gctattggg  ttaaaaaga  agttaagtt  2460
gtgatccat  gctgtcaag  gggttacaa  ttgaataag  tctatgcna  aaataaatt  2520
ttgtaaaaa  tgaaaataa  aattgactg  at  2552



<210> 571
<211> 451
<212> PRT
<213> Rattus norvegicus
<308> AAB86925
<400> 571

Met Gly Ala Leu Met Ala Thr Tyr Ser Glu Gly Met Met Gly Cys Ser 
  1               5                  10                  15
Ser Val Gly Arg Cys Phe Ser Ser Thr Leu Ser Pro Ile Ile Thr Leu 
             20                  25                  30
Val Ala Thr Ser Met Lys Ser Thr Pro Arg Val Leu Glu Asn Lys Ala 
         35                  40                  45
Asp Phe Gln Arg Ser Asp Arg Ile Asp Met Glu Thr Asn Thr Lys Asp 
     50                  55                  60
Leu Lys Gly Ala Gly Val Thr Val His Pro Pro Arg Ala Ser Glu Val 
 65                  70                  75                  80
Asn Leu Glu Glu Leu Pro Pro Leu Asn Tyr Phe Val His Ala Phe Tyr 
                 85                  90                  95
Tyr Ser Trp Tyr Gly Asn Pro Gln Phe Asp Gly Lys Tyr Val His Trp 
             100                105                110
Asn His Pro Val Leu Glu His Trp Asp Pro Arg Ile Ala Lys Asn Tyr 
         115                120                125
Pro Gln Gly Arg His Ser Pro Pro Asp Asp Ile Gly Ser Ser Phe Tyr 
     130                135                140
Pro Glu Leu Gly Ser Tyr Ser Ser Arg Asp Pro Ser Val Ile Glu Thr 
 145                150                155                160
His Met Lys Gln Met Arg Ser Ala Ser Ile Gly Val Leu Ala Leu Ser 
                 165                170                175
Trp Tyr Pro Pro Asp Ala Ser Asp Glu Asn Gly Glu Ala Thr Asp Tyr 
             180                185                190
Leu Val Pro Thr Ile Leu Asp Lys Ala His Lys Tyr Asn Leu Lys Val 
         195                200                205
Thr Phe His Ile Glu Pro Tyr Ser Asn Arg Asp Asp Gln Asn Met His 
     210                215                220
Gln Asn Val Lys Tyr Ile Ile Asp Lys Tyr Gly Asn His Pro Ala Phe 
 225                230                235                240
Tyr Arg Tyr Lys Thr Arg Met Gly His Ser Leu Pro Met Phe Tyr Ile 
                 245                250                255
Tyr Asp Ser Tyr Ile Thr Lys Pro Lys Thr Trp Ala Asn Leu Leu Thr 
             260                265                270
Pro Ser Gly Ser Gln Ser Val Arg Gly Ser Pro Tyr Asp Gly Leu Phe 
         275                280                285
Ile Ala Leu Leu Val Glu Glu Lys His Lys Tyr Asp Ile Leu Gln Ser 
     290                295                300
Gly Phe Asp Gly Ile Tyr Thr Tyr Phe Ala Thr Asn Gly Phe Thr Tyr 
 305                310                315                320
Gly Ser Ser His Gln Asn Trp Asn Lys Leu Lys Ser Phe Cys Glu Lys 
                 325                330                335
Asn Asn Met Ile Phe Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr 
             340                345                350
Ser Ile Arg Pro Trp Asn Thr Gln Asn Thr Arg Asn Arg Ile Asn Gly 
         355                360                365
Lys Tyr Tyr Glu Val Gly Leu Ser Ala Ala Leu Gln Thr Gln Pro Ser 
     370                375                380
Leu Ile Ser Ile Thr Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile 
 385                390                395                400
Glu Lys Ala Val Pro Lys Arg Thr Ala Asn Thr Val Tyr Leu Asp Tyr 
                 405                410                415
Arg Pro His Lys Pro Ser Leu Tyr Leu Glu Ile Thr Arg Lys Trp Ser 
             420                425                430
Glu Lys Tyr Ser Lys Glu Arg Met Thr Tyr Ala Leu Asp Gln Gln Leu 
         435                440                445
Pro Ala Ser 
     450



<210> 572
<211> 2388
<212> DNA
<213> Homo sapiens
<308> NM_024641
<400> 572

attttatta  agttggtat  gaaatccac  atttgatgg  aaatatata  attggaatc  60
tccagtgtt  gagcattgg  accctagaa  agccaagaa  tatccacaa  ggagacaca  120
ccctccaga  gacattggc  ccagctttt  tcctgaatt  ggaagttac  gttctcggg  180
tccttctgt  atagaaact  acatgagac  aatgcgctc  gcttcaatt  gtgtactag  240
cctctcttg  tacccacct  atgtaaatg  tgaaaatgg  gaacctact  ataacttgg  300
acccactat  ttggataaa  ctcataaat  taacctaaa  gttactttt  acatagaac  360
atatagcaa  cgagatgat  aaaacatgt  caaaaatgt  aagtatatt  tagacaaat  420
tggaaatca  ccggccttt  acaggtaca  gacgaagac  ggcaatgct  ttcctatgt  480
ttatgtcta  gattcctat  ttaccaagc  tgaaaaatg  gccaatctg  taaccacct  540
agggtctcg  agtattcgc  attctcctt  tgatggact  tttattgcc  ttctggtag  600
agaaaaaca  aagtatgat  ttcttcaaa  tggttttga  ggaatttac  catattttg  660
cacaaatgg  tttacttat  gctcatcac  tcagaattg  gctagccta  aattaattt  720
tgataaata  aacttaata  ttatcccaa  tgtgggccc  ggatacata  ataccagca  780
ccgtccatg  aacacgcaa  acactcgga  ccgaatcaa  gggaagtat  atgaaattg  840
tctgagtgc  gcacttcag  cacgcccca  cttaatttc  atcacctct  ttaatgagt  900
gcatgaagg  actcagatt  aaaaagctg  tcccaaaag  accagtaat  cagtgtacc  960
agattaccg  cctcataaa  caggtcttt  cctagaact  actcgcaag  ggtctgaaa  1020
atacagtaa  gaaagagca  cttatgcat  agatcgcca  ctgcctgtt  cttaatgca  1080
tgattaaag  ttaatagtt  tcaaaatca  ctaattttt  aaaatagct  tcgttttga  1140
ttctggaaa  aaaactgtc  aaatcagta  atactatta  ttatattta  aaatatttt  1200
ttaaattct  tacagataa  attatactt  ttacccttc  caataccac  tgagaaaat  1260
tctgagaca  aatgtatac  aatatattc  ttatggcat  atttattgc  tttctgact  1320
aaatcaaaa  tctgatttg  tggcaattg  attttcatt  tacaataga  aaatgcttg  1380
gttacctaa  gcacttagc  cacagttaa  ttatattta  atcctagac  caaataaat  1440
ggattgtgt  tatatttgg  atatctatt  aagaaaaaa  gaaaacccc  taaagataa  1500
gtacatgct  catgtcatg  ctttaaaat  atttaatca  ctttattgt  ttagtattt  1560
gactctgga  aactctaca  taatgagga  attcttaag  ataacaaaa  cactgtacc  1620
tcctctcaa  tttgctgtg  acctgaaat  gctttaaat  aatactctt  ttttttatt  1680
aatttaatt  cataaatta  accttacca  gaccaaatt  tgttaggaa  gcctgctat  1740
tacagcaca  tgtgtcatt  gcagatttg  ggttaccta  accacgcta  gtgttttga  1800
atgtttagt  tttctgctt  acagtgctg  attccatat  ttagaagct  tgaaagtcc  1860
tttatgaaa  agttactga  tgcttctca  ttattagga  aacagttgt  tcacaatta  1920
tatgtagat  tgatgccca  atatcattt  tagtatatc  tgtcgatct  taagttgtt  1980
ctattgtgt  attcatgtc  ttaaatcag  taccaaata  tttttagga  agaaaaatg  2040
tattactgt  attaggttg  cttttaata  tttaagtta  tttgacgaa  agtaataga  2100
aaaatttac  tagcatttt  gattctaga  acatggaaa  gaaaattat  ttatgtcta  2160
agtaggtcc  gaagtttgg  tttacatta  gtttagcac  gtatcagaa  gaagaaact  2220
atattttac  taaaaacta  tactttcaa  tttttatat  gtaatatcc  cattttgta  2280
atgttagac  tttatcata  ctgtaagtt  aaatacttg  tatcaataa  ttgtcatat  2340
gtgacaaat  gatcacttg  gtacgaaaa  taaatctcc  taaaaact  2388



<210> 573
<211> 290
<212> PRT
<213> Homo sapiens
<308> NP_078917
<400> 573

Met Arg Gln Met Arg Ser Ala Ser Ile Gly Val Leu Ala Leu Ser Trp 
  1               5                  10                  15
Tyr Pro Pro Asp Val Asn Asp Glu Asn Gly Glu Pro Thr Asp Asn Leu 
             20                  25                  30
Val Pro Thr Ile Leu Asp Lys Ala His Lys Tyr Asn Leu Lys Val Thr 
         35                  40                  45
Phe His Ile Glu Pro Tyr Ser Asn Arg Asp Asp Gln Asn Met Tyr Lys 
     50                  55                  60
Asn Val Lys Tyr Ile Ile Asp Lys Tyr Gly Asn His Pro Ala Phe Tyr 
 65                  70                  75                  80
Arg Tyr Lys Thr Lys Thr Gly Asn Ala Leu Pro Met Phe Tyr Val Tyr 
                 85                  90                  95
Asp Ser Tyr Ile Thr Lys Pro Glu Lys Trp Ala Asn Leu Leu Thr Thr 
             100                105                110
Ser Gly Ser Arg Ser Ile Arg Asn Ser Pro Tyr Asp Gly Leu Phe Ile 
         115                120                125
Ala Leu Leu Val Glu Glu Lys His Lys Tyr Asp Ile Leu Gln Ser Gly 
     130                135                140
Phe Asp Gly Ile Tyr Thr Tyr Phe Ala Thr Asn Gly Phe Thr Tyr Gly 
 145                150                155                160
Ser Ser His Gln Asn Trp Ala Ser Leu Lys Leu Ile Cys Asp Lys Tyr 
                 165                170                175
Asn Leu Ile Phe Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser 
             180                185                190
Ile Arg Pro Trp Asn Thr Gln Asn Thr Arg Asn Arg Ile Asn Gly Lys 
         195                200                205
Tyr Tyr Glu Ile Gly Leu Ser Ala Ala Leu Gln Thr Arg Pro Ser Leu 
     210                215                220
Ile Ser Ile Thr Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu 
 225                230                235                240
Lys Ala Val Pro Lys Arg Thr Ser Asn Thr Val Tyr Leu Asp Tyr Arg 
                 245                250                255
Pro His Lys Pro Gly Leu Tyr Leu Glu Leu Thr Arg Lys Trp Ser Glu 
             260                265                270
Lys Tyr Ser Lys Glu Arg Ala Thr Tyr Ala Leu Asp Arg Gln Leu Pro 
         275                280                285
Val Ser 
     290



<210> 574
<211> 4076
<212> DNA
<213> Rattus norvegicus
<308> AF025308
<400> 574

gggcttgca  ccagcgcct  ctcttaaga  aagcgtctc  ccaccgcat  cacaggctt  60
tgttgtgat  tattcgcga  gtggctttc  tctgaagac  ccagggtct  acttctgaa  120
agaagaagg  agaggaggg  ggaggagca  acagaaagg  ctggaggcg  cccctggtg  180
tcaggcagc  tctgggtca  aacttggag  caccatgac  aacagcgtc  gtcccacag  240
ccaaggttc  ggcaaagtc  tagccaggc  gtgtggtca  gggccgggc  ggggattcc  300
catctcccc  gtttcactt  tgcttctaa  ctgtgtcag  tccttctgc  cggatactg  360
tgacgcgct  gcaattctc  cattcctat  gggtgccgt  attccggtg  accaatcag  420
gttgcccag  cactagatg  aaactccac  cagccgcgg  actcagccg  gtccgggac  480
tcggatagg  gcgatggca  cgcgcacgc  gctcctgct  ctggcggcc  ccctggccc  540
gacccaggt  cgcgcgggt  agtgcgggg  cgggaggga  acggcctct  cggggaggc  600
cgggagcgg  acggggaag  ggtccccgg  cgcacccaa  accccggcc  cttctccac  660
gcgtccgga  ccccggccc  tgctccccg  gcgccggca  ccgcccggg  tcctgggag  720
aggtcggga  ctcaccgcg  gccgccccc  ggctcacac  cgctgcggt  tttccacac  780
gccgtgtcc  ggcccggcc  cggggagcc  cggttcatt  tcgtcggct  cgtggacga  840
acggagttc  tgcgctacg  cagcgacgc  gagaatccg  gatacgagc  gcgggttgg  900
tggatggag  gggagggtc  ggagtattg  gagcgggag  cactgatgg  caaggaaaa  960
gagcaggtt  accgagtga  cctgaggac  ctgctccgc  actacaacc  gagcgaggg  1020
ggtgagtga  cccgggtcg  aggtcagga  ccctccccg  ccccacacg  ccggagact  1080
ccgggtccg  agtccaggt  cgggaacag  accgacccg  accggtttc  ctttcactt  1140
ggaggagtc  gcgggtggg  ggaacgggt  ggcggggcc  ggcctgacc  cggggtccc  1200
caggctctc  caccatcca  tggatgtcc  gctgtgacg  ggggtcgga  gggagcctc  1260
tccgcgggt  tgatcagtt  gcctacgac  gccgcgatt  cctcgccct  aacgaagac  1320
tgaaaacgt  gatggcggc  gacacggcg  cacagatga  ccgaaacaa  tgggatcag  1380
caggtgaag  agagagaca  aaggcctac  tgcagggca  gtgtgtgga  tggctccgc  1440
gatacctgg  gctcgggaa  gagacgctg  tgcgctcag  tgcgggggc  gcgggcttc  1500
cctcctctg  cctcgggct  gggctcagt  ctggggaag  agaaaccct  agctgggtg  1560
tgcccctgt  tcagagggg  gacagtgtc  ctgggtctc  ctgatccct  atcacggtg  1620
ctgcactgc  tctcccaca  ggcccagcc  tctccctgg  gagttctga  tccctctca  1680
gagaaggag  gaatttccc  cttaacagc  ggggctccc  gctgtcagc  atggcctct  1740
ccaggcatg  tctctgccc  cacccactc  ctgaggaca  tgactcctg  cctgctgag  1800
gtgtcagcc  ttacacctc  ggaacagaa  tctccttta  ctcacagga  tccactact  1860
taggctggt  cccacagtt  ctaaaagat  ccccgggtt  ctcacagat  cctccctga  1920
gtggggttg  catcccttc  ataccccat  tctctctct  cctacagtg  agaatggta  1980
catgagccc  tatggggta  cctggagga  tataaattg  gggatttct  tttcttttt  2040
ctttttttc  ctctttttc  tatctttta  ttccttttt  ctttccttt  ttttttttt  2100
ttttttttg  aaggcatta  tttacttcc  gtcaggttt  ctctgcaaa  acatattaa  2160
tcaattatt  tctattccc  cttctgttc  gtgaccacc  atctcatgc  ataaaacac  2220
cgtaaagga  ggccatgtt  acccactcg  tcatgtgga  tccctctta  cttctgagt  2280
cctcaggaa  gtgtgcagt  ctgtgctga  ggaaccagc  ctccctgca  ctcactagg  2340
agatgacag  tgaagtgtc  gacacacac  gttcagtgt  atccttgat  taactgtgt  2400
ctgtgtaga  ttcagtttg  cttgttaac  gtgtgattt  ttaaatctt  cacacagat  2460
ccccaaagg  acatgtgac  cttcacccc  gacctgaag  tgatgtcac  ctgaggtgc  2520
gggccctgg  cttctaccc  gctggcata  tcctgacct  gctgttgaa  ggggaggat  2580
tgacccagg  catggagct  gtggagacc  ggcctgcag  ggatggaac  ttccagaag  2640
gggcatctg  ggtggtgcc  cttgggaag  agcagaatt  cacatgcct  gtggagcat  2700
aggggctgc  tgatcctct  accctgaga  ggggtaagg  gggtgtggg  atagagctg  2760
ggtcaggaa  agctggagc  ttttacaga  cctgagctg  tcaaggctg  gagctggtg  2820
tcctgaccc  caccttcat  tcctgtacc  gtccttccc  gaggctcct  catccactg  2880
ccccaacat  gaaaccact  tcatttatg  tgtcgttgg  gctgtggtc  tcactggag  2940
tgtgaccat  attggagct  tgctgactg  tgtgagggg  aggaagaga  acacaggta  3000
gaaagggca  ggtcttgtt  cccctcagc  tcctttaga  gagcgctct  atcattaat  3060
ggaagcaca  ccacacccc  cattgctgc  gtctccaac  gggtcctct  tcagttctg  3120
aaacttcct  ctgtcaaga  cttccttga  ctctcacag  ttttcttct  acaggtggg  3180
aagtaggag  ctacacccc  gctccaggt  agtgttggg  caggagtgt  cctgagggt  3240
ttggagtga  gctggagat  tggggaact  ggggaatcc  tagtagctc  tccatagaa  3300
tcttctggg  gcctcagtt  taccgtgat  tgaatacat  catatacac  tatacatat  3360
cagaacaca  tacgtgtgt  tgtgtgtgt  tgtgtgtgt  tgtgtgtgt  tgtgtgtgt  3420
tgttttctt  taccctagg  aaggacagc  ccgagagct  tgatgtgtc  ctcccagat  3480
gtaaaggta  ctctgggtc  gactgggga  gggcaatgt  gacatgatt  cgtttcagg  3540
actcccaga  tcccctgtg  gtggagggt  gttgggctg  tgtcttcac  gtgatggtt  3600
gtgactctc  ttctctagc  tgaagacag  tgcctggag  ggactgagt  acagacgat  3660
tgttcaggt  tctcctgtg  catccagag  cctcaggtc  ctttagaca  cagtgtctg  3720
tgttccctg  gattctatg  cttcagtgt  aagaactgt  gagcccagg  tgccctgca  3780
acctggacc  tgtccctgc  ctgcctgca  tcccttcca  attcaacct  gctggtcca  3840
cctggggtt  ggggggtgg  gacatatgc  tcctgtcac  cagtgctgc  ttgagctgc  3900
actcctcac  tctacactg  gaataagaa  ctgagtgtg  acttgactg  tcacatcct  3960
gacacaagt  ttgattgct  tttaaatta  tggattgaa  acttagagg  tctttgttt  4020
ttatttttg  tttgttttg  tttctttgt  ttgttttaa  ataaatggc  ggtgga  4076



<210> 575
<211> 368
<212> PRT
<213> Rattus norvegicus
<308> AAB82285
<400> 575

Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Ala Leu Ala Pro 
  1               5                  10                  15
Thr Gln Val Arg Ala Gly Ser His Ser Leu Arg Tyr Phe His Thr Ala 
             20                  25                  30
Val Ser Arg Pro Gly Leu Gly Glu Pro Arg Phe Ile Ile Val Gly Tyr 
         35                  40                  45
Val Asp Asp Thr Glu Phe Val Arg Tyr Asp Ser Asp Ala Glu Asn Pro 
     50                  55                  60
Arg Tyr Glu Pro Arg Val Gly Trp Met Glu Arg Glu Gly Pro Glu Tyr 
 65                  70                  75                  80
Trp Glu Arg Glu Thr Leu Met Val Lys Glu Asn Glu Gln Val Tyr Arg 
                 85                  90                  95
Val Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser Glu Gly Gly 
             100                105                110
Ser His Thr Ile Gln Trp Met Ser Gly Cys Asp Val Gly Ser Asp Gly 
         115                120                125
Ser Leu Leu Arg Gly Tyr Asp Gln Phe Ala Tyr Asp Gly Arg Asp Tyr 
     130                135                140
Leu Ala Leu Asn Glu Asp Leu Lys Thr Trp Met Ala Ala Asp Thr Ala 
 145                150                155                160
Ala Gln Met Thr Arg Asn Lys Trp Asp Gln Ala Gly Glu Ala Glu Arg 
                 165                170                175
His Lys Ala Tyr Leu Gln Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr 
             180                185                190
Leu Glu Leu Gly Lys Glu Thr Leu Leu Arg Ser Asp Pro Pro Lys Ala 
         195                200                205
His Val Thr Leu His Pro Arg Pro Glu Gly Asp Val Thr Leu Arg Cys 
     210                215                220
Trp Ala Leu Gly Phe Tyr Pro Ala Gly Ile Phe Leu Thr Trp Leu Leu 
 225                230                235                240
Asn Gly Glu Asp Leu Thr Gln Asp Met Glu Leu Val Glu Thr Arg Pro 
                 245                250                255
Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu 
             260                265                270
Gly Lys Glu Gln Asn Tyr Thr Cys Leu Val Glu His Glu Gly Leu Pro 
         275                280                285
Asp Pro Leu Thr Leu Arg Trp Glu Ala Pro Pro Ser Thr Asp Pro Asn 
     290                295                300
Met Glu Thr Thr Val Ile Tyr Val Val Val Gly Ala Val Val Ile Thr 
 305                310                315                320
Gly Ala Val Thr Met Ile Gly Ala Leu Leu Thr Val Val Arg Gly Arg 
                 325                330                335
Lys Arg Asn Thr Gly Gly Lys Val Gly Val Tyr Thr Pro Ala Pro Gly 
             340                345                350
Lys Asp Ser Ser Glu Ser Ser Asp Val Ser Leu Pro Asp Cys Lys Ala 
         355                360                365



<210> 576
<211> 6400
<212> DNA
<213> Rattus norvegicus
<308> AF026504
<400> 576

gaattcggc  cgagaagaa  ttaaaggcc  cctcttgtg  gtttgtgga  tgctggagg  60
ggctgctct  cctctctct  caggatgta  gcacccatg  aggattctg  gctcaagct  120
tgtgcctgc  gcctcctgc  tgacgagct  ctgaggaag  tcgtcttac  gtccgtcac  180
tgggaagga  ggtaacagt  ctctgtaat  tggtagagg  catggagcc  gctgccttg  240
gcggtcttt  gcttctgtc  tcgtcgttg  catcatcat  aatcagcac  gatggggcg  300
agggggccg  tctgcttaa  gaaacgcag  cattttgtg  attagtgaa  ggcttccag  360
tcagagtaa  tggaagtcg  gagatcttg  gaagaagtg  ctgtgaatg  tgggctcct  420
cagtgctct  cttgtgggg  gagcatggg  ttatggcaa  cacagaacc  cagtgatgc  480
agttctgtt  aatcttttc  gaaggaagc  tgctgttag  gcacaggaa  tgttgtgga  540
tacaatgtt  gaaagatac  ggttctcag  ggtctgaaa  cacggcatc  tttaacctt  600
taaatgaca  ggcttaaga  ctcaacact  ctgctgtat  ttctggaag  cattctcta  660
agcaaaagt  cacatttaa  atgcaaaca  ggtgatcct  tctccaggg  tttaagtga  720
cacttttta  gtcatgacc  gcttgaaga  gtcgcagac  gaaaggcct  tcactgctg  780
cagagcctc  gttgtcagc  cagatggca  ccccaaagt  cacactgat  atttctaca  840
gcgtcgctt  cggtcccaa  atggcagct  aggatcatc  gtcatggct  cagtagggc  900
ccctcgaag  gaaggtcct  accatataa  ctcaacccc  ggagtcccc  agatggggg  960
tagggcaag  attgcagat  ggcctccaa  aaaggaaaa  gtaaaagaa  ctagccgtt  1020
aagccagga  atagaaacc  caagttgcc  tgagagcct  tcctccaaa  gcagtcctg  1080
gagtcaggg  agttctgtt  gcctcaatt  caatgactc  gccatgctg  agagcatcc  1140
gaacaccct  aagaacaag  cggggccag  ggagagcat  gactcgaga  tcctcatgc  1200
tgaagccta  cccagctcc  ccaggaaag  ccttcgccg  atccgtcag  gtagcaaca  1260
tgatatcac  ataagtgag  ttgatgtgg  tagttttga  gaatgtatc  ccccaacct  1320
caagtcggg  ccatcattg  acagggaat  tggtagcac  tcttcaatc  acaagcagg  1380
gacatccgg  gaaagcttc  tcggtttgt  aaagggcta  aaagacgac  gagctgacc  1440
aggtccaac  ccaaccaaa  tcagtgact  cctcatcac  ggtgggggc  agggttctg  1500
tttctcctt  gatgtgatc  atggaccca  ttcacagag  gagaacctc  ggctattca  1560
ggaaaggga  aaaccactc  agcgacgtt  taagtctga  actggagac  catccattt  1620
tcgtaaatt  cgcaatgcc  aaggtgaag  actcgggaa  tcatcagac  ttgaagaca  1680
cagatcaga  gattctgtg  ggccctgga  atgtccaaa  tgctttgcc  actatgatg  1740
ccagagcat  ttgtttgac  tgaatgaag  cattatgaa  aggcataat  tgattaaga  1800
gagaaacac  acaacggga  cttctgcag  cgctgtggc  tccttagtc  cgggacctt  1860
gtctcactc  accagcttc  gctctccta  gggcagcac  gaggacttc  attccaaag  1920
aagcctcgg  atggaccag  gagatgaca  gagcaatga  ctcgtcatg  gctgtccgt  1980
ctttcggaa  gagattggg  gagaaggtg  gaggaaaat  agcctgtcc  agtccaatt  2040
tggctcatt  agtgggtgt  agagcacgt  ctttgagtc  gccctcagc  ctcactgca  2100
aaacgcagg  gtggcggtt  tcgaagtgc  caaggagag  ttgatgctg  atctagaca  2160
agtgagacg  tacactgtg  agcacgtgg  tcttggagc  tactattac  ggaagtgct  2220
ctaccaaaa  gaacactgg  actattttg  ggctgatga  aacctcggt  cagtggctg  2280
gagcattcg  agggaaaaa  cagaagaca  gaaggaaaa  ggatctccc  acaactacc  2340
aataatttt  agaactagt  agctcatga  actgagagg  tctgtcctg  aggatgcca  2400
tccctccac  gccaagcac  cgacagcca  aggattgcc  ctgaaagag  tgctggaac  2460
tgtgatccc  gagctcaac  tgcagtgcc  gcgtttggc  ttcaacacg  ccaaagtca  2520
cgagcagct  atgaaactg  acgagcaag  gctgaacta  cagcagaaa  taggcatca  2580
gtactgcaa  gcaggccag  gcaccgagg  ggagatgta  aacacgccc  aagtcacgg  2640
gcagtttat  aaactggac  agcaagggc  gaattatca  cagaaagta  gcatcatgt  2700
ctgcaaagc  ggccagagc  ccgaggagg  gatgtacaa  aatgagtcc  ctggcccgg  2760
ctttgagga  tttcttcag  tactgggag  gcgagttcg  ctaaaagga  ttgaaaagt  2820
tcgtgcgca  ctcgacacc  aaactgact  cactggaac  cactctctg  acacaacct  2880
caaagacta  gagataatg  tccacgtct  caccatgct  ccctacaca  ctaacaaca  2940
gcaacagct  ctgaggaag  ggcacattg  gaatgacat  gtgacaata  ttttccagg  3000
gcctggagc  caaccattt  gcccgaaaa  catccgatc  cactttcag  atgtttttg  3060
cattgtccg  gctcacaac  cctgcactg  gagtgtctg  tacagtgtg  cagtcacca  3120
gtccagaga  gtgccttct  ttggacctc  catccctaa  ggggtcacc  tccccaagt  3180
aaacgtgtt  agggacttc  ttttggcca  agtgattaa  gcagaaaac  ctgctcata  3240
atcagagaa  ttcagggcc  tggcaacaa  gacccgcca  gaatacctg  aagatctgg  3300
agaaaagaa  gtcaccaac  cacctattg  cccttctgg  aagtttcca  ttatttctc  3360
ggcttctaa  aagaaggaa  agtctaagc  ttacccagg  gctgagctc  gtagcatgg  3420
ggccattgt  tgggcagtc  gggccaaag  ctacaacaa  gccatggaa  tcgactgcc  3480
ccttggaat  tccaatgag  tcatcgtcc  cattgagca  gaaacaaag  gcgtggttt  3540
caattgctc  tgcagagat  tgatagggt  gacttccag  gacagcagc  ttaagatct  3600
ctatgagcg  ggagaatgc  tttctgtgg  gagcttcat  agcagtgaa  atatcaaag  3660
aattgtcaa  aggctgcag  ttgtttcaa  aggttgtga  tcagtggag  tgacgctgc  3720
aagaaatgg  ctaggccag  ttggcttcc  tgtcaacta  gagggcatc  tggcggatg  3780
agaacccta  ggctatgca  ggcaagcag  tttgaagca  ggcagccgc  tggtggaga  3840
ctgcaaggt  gcagtggcc  ccctgagcc  tgaacagat  atcgatctc  tgagaacgt  3900
agtcacagt  aaagttgtc  ttatccctc  ccatgatga  tgcacccct  ggaggagtt  3960
ctcagaaac  taccgcatg  cagtgatgg  gtacaagat  aatgaaggc  tttcctatg  4020
gtacaagtt  cccttccgg  gtaacaaca  atggcagcg  aatgccggc  agggtgccc  4080
ttcgcccca  gttccattg  agctgcaga  ccccatgat  tcacgggtg  atgctggga  4140
gggagatgg  aagatgccc  ttccagaaa  agccgccaa  atccctcga  gcatctcca  4200
tgatgggcg  ccactggaa  ggaggctgt  tcctggttc  gacatctat  tgacagtct  4260
atccatggc  ttggcgaga  cccagtgcc  taactcccc  agcaacttg  catcgtcca  4320
cgagactgg  tctgggggt  gcacttaca  acaaaaatc  atgcctgaa  ggtttggag  4380
gagccgaag  tccccagct  ccatcgaca  gcaaaacac  cagtcggat  ttggtggca  4440
tggaaaatc  acacccagc  ggcagagaa  tgaggacag  cttgccgac  agatggagc  4500
tacatgcca  ctcccagca  tatctaagg  actgcctgc  ttccgagag  gccccagtg  4560
gaggttgat  cggcaggat  ccgtggttc  cttgtctcc  aacaagcaa  gccattctg  4620
cagccacta  tccagccac  ccagcagca  cactctgtc  agcaacgcc  cgagtgccc  4680
cagtgacga  aagtggtac  atggagacc  caccgagtc  gacctcaac  gctataact  4740
cctacaggg  acatctgct  acagcggca  cgacaccgc  tcatacggc  tcagccatg  4800
cagcacggc  tccctggga  cctccacat  ctcacctcg  tcagggcca  gcaaagaga  4860
ggtggcacc  ctgtggcac  gctccagtg  ggtgctctc  ctggcagat  ggaccttag  4920
gactgaggg  catggcatg  acaggaaaa  agagtcctc  ctgagcctg  acatccaca  4980
caagagcca  ggcggttca  gcccgctga  aagggagaa  agcaccttc  gcataaatg  5040
tgccacatc  cacaccagt  ccatgagct  ccgacactc  gccagccca  tggtgttct  5100
cagtgccag  agttcaccc  aagaagagc  tcaccccac  acgtcctcc  agctcgcac  5160
ttccttctc  tcctcttcc  catcttcct  tggacctag  actttctat  cccgccagg  5220
cgccactag  aaatacctg  ttggatgga  aaagccaga  ggaaccatt  actccgtgg  5280
atttatgga  acaagaaag  gacatcaga  tgatggtaa  gagatagcc  acactaggc  5340
tcgagcctc  accagggac  ttcgggcat  cccaaagcc  acttccaag  ccaccattg  5400
ggaggatct  aagaaactc  tcgaccttg  gagcccaac  cctgaatca  agaaaaact  5460
caagttcca  ggactgtcc  ccccacagt  cccgttccc  agcacccct  cctcccggc  5520
ggccctgca  aggactctg  ctgatgaga  catttacag  agccagagg  agcatttct  5580
cacctccag  gcctcactt  tagaccaag  cctgcccaa  gatgtcttt  tcagcagca  5640
ttacccatc  ctccccaag  cgcttccac  gaggaggcc  tcttacaca  tgggaatga  5700
gtcgctgca  ggagagttc  ttgcttccg  cagctccct  accgacatc  aggagaccc  5760
gaggcagcc  attcctgac  ctggcctga  gcccctgcc  gacactgct  cggacttgg  5820
ctggtccaa  ctagtagat  ccgccaaag  ctatgaggt  cagagagcc  cattttttg  5880
tgctagtga  gaaaaccat  gccccttga  tgcggcctc  aacagcgac  agctagagg  5940
gcaggccct  gtccagatg  agtcgtaca  cagcagtaa  gactcctct  ccactctgg  6000
ttctaaagt  gaccagttg  aaggtatgc  gaaaatgct  cgagaagat  tgaagaagg  6060
aaaggaaga  aaggcccac  tgcaggcag  ggttgagca  ttgcgggag  acaacctga  6120
gctgcagga  gagtcccag  atgcctcgg  caagctgaa  aagttcaca  agtgggtct  6180
caacaccat  gacatgagc  agggccagc  gaggggaaa  gaggagggc  ggctgctct  6240
tatgggcac  ctaaagcac  cattcatgc  ttggaaagt  ttctcagag  cccagcttc  6300
cagtctgct  atattggac  gtgcacaat  caacaactg  agatcaaca  tcattatct  6360
ccttttata  aaaagaaaa  acaaaacnc  tgccgaattc  6400



<210> 577
<211> 1822
<212> PRT
<213> Rattus norvegicus
<308> AAB81526
<400> 577

Met Thr Ser Leu Lys Arg Ser Gln Thr Glu Arg Pro Val Thr Ala Asp 
  1               5                  10                  15
Arg Ala Ser Val Val Ser Thr Asp Gly Thr Pro Lys Val His Thr Asp 
             20                  25                  30
Asp Phe Tyr Met Arg Arg Phe Arg Ser Gln Asn Gly Ser Leu Gly Ser 
         35                  40                  45
Ser Val Met Ala Ala Val Gly Pro Pro Arg Ser Glu Gly Pro His His 
     50                  55                  60
Ile Thr Ser Thr Pro Gly Val Pro Lys Met Gly Val Arg Ala Arg Ile 
 65                  70                  75                  80
Ala Asp Trp Pro Pro Arg Lys Glu Asn Val Lys Glu Ser Ser Arg Ser 
                 85                  90                  95
Ser Gln Glu Ile Glu Thr Ser Ser Cys Leu Glu Ser Leu Ser Ser Lys 
             100                105                110
Gly Ser Pro Val Ser Gln Gly Ser Ser Val Ser Leu Asn Ser Asn Asp 
         115                120                125
Ser Ala Met Leu Lys Ser Ile Gln Asn Thr Leu Lys Asn Lys Thr Gly 
     130                135                140
Pro Ala Glu Ser Met Asp Ser Arg Phe Leu Met Pro Glu Ala Tyr Pro 
 145                150                155                160
Ser Ser Pro Arg Lys Ala Leu Arg Arg Ile Arg Gln Arg Ser Asn Ser 
                 165                170                175
Asp Ile Thr Ile Ser Glu Leu Asp Val Asp Ser Phe Asp Glu Cys Ile 
             180                185                190
Ser Pro Thr Tyr Lys Ser Gly Pro Ser Leu His Arg Glu Tyr Gly Ser 
         195                200                205
Thr Ser Ser Ile Asp Lys Gln Gly Thr Ser Gly Glu Ser Phe Phe Gly 
     210                215                220
Leu Leu Lys Gly Tyr Lys Asp Asp Arg Ala Asp Arg Gly Pro Thr Pro 
 225                230                235                240
Thr Lys Leu Ser Asp Phe Leu Ile Thr Gly Gly Gly Lys Gly Ser Gly 
                 245                250                255
Phe Ser Leu Asp Val Ile Asp Gly Pro Ile Ser Gln Arg Glu Asn Leu 
             260                265                270
Arg Leu Phe Lys Glu Arg Glu Lys Pro Leu Lys Arg Arg Ser Lys Ser 
         275                280                285
Glu Thr Gly Asp Ser Ser Ile Phe Arg Lys Leu Arg Asn Ala Lys Gly 
     290                295                300
Glu Glu Leu Gly Lys Ser Ser Asp Leu Glu Asp Asn Arg Ser Glu Asp 
 305                310                315                320
Ser Val Arg Pro Trp Thr Cys Pro Lys Cys Phe Ala His Tyr Asp Val 
                 325                330                335
Gln Ser Ile Leu Phe Asp Leu Asn Glu Ala Ile Met Asn Arg His Asn 
             340                345                350
Val Ile Lys Arg Arg Asn Thr Thr Thr Gly Ala Ser Ala Ala Ala Val 
         355                360                365
Ala Ser Leu Val Ser Gly Pro Leu Ser His Ser Thr Ser Phe Ser Ser 
     370                375                380
Pro Met Gly Ser Thr Glu Asp Phe Asn Ser Lys Gly Ser Leu Gly Met 
 385                390                395                400
Asp Gln Gly Asp Asp Lys Ser Asn Glu Leu Val Met Ser Cys Pro Tyr 
                 405                410                415
Phe Arg Asn Glu Ile Gly Gly Glu Gly Glu Arg Lys Ile Ser Leu Ser 
             420                425                430
Lys Ser Asn Ser Gly Ser Phe Ser Gly Cys Glu Ser Thr Ser Phe Glu 
         435                440                445
Ser Ala Leu Ser Ser His Cys Thr Asn Ala Gly Val Ala Val Leu Glu 
     450                455                460
Val Pro Lys Glu Ser Leu Met Leu His Leu Asp Arg Val Arg Arg Tyr 
 465                470                475                480
Thr Val Glu His Val Asp Leu Gly Ala Tyr Tyr Tyr Arg Lys Cys Phe 
                 485                490                495
Tyr Gln Lys Glu His Trp Asn Tyr Phe Gly Ala Asp Glu Asn Leu Gly 
             500                505                510
Pro Val Ala Val Ser Ile Arg Arg Glu Lys Pro Glu Asp Met Lys Glu 
         515                520                525
Asn Gly Ser Pro Tyr Asn Tyr Arg Ile Ile Phe Arg Thr Ser Glu Leu 
     530                535                540
Met Thr Leu Arg Gly Ser Val Leu Glu Asp Ala Ile Pro Ser Thr Ala 
 545                550                555                560
Lys His Ser Thr Ala Arg Gly Leu Pro Leu Lys Glu Val Leu Glu His 
                 565                570                575
Val Ile Pro Glu Leu Asn Val Gln Cys Leu Arg Leu Ala Phe Asn Thr 
             580                585                590
Pro Lys Val Thr Glu Gln Leu Met Lys Leu Asp Glu Gln Gly Leu Asn 
         595                600                605
Tyr Gln Gln Lys Val Gly Ile Met Tyr Cys Lys Ala Gly Gln Ser Thr 
     610                615                620
Glu Glu Glu Met Tyr Asn Thr Pro Lys Val Thr Glu Gln Phe Met Lys 
 625                630                635                640
Leu Asp Glu Gln Gly Leu Asn Tyr Gln Gln Lys Val Gly Ile Met Tyr 
                 645                650                655
Cys Lys Ala Gly Gln Ser Thr Glu Glu Glu Met Tyr Asn Asn Glu Ser 
             660                665                670
Ala Gly Pro Ala Phe Glu Glu Phe Leu Gln Leu Leu Gly Glu Arg Val 
         675                680                685
Arg Leu Lys Gly Phe Glu Lys Tyr Arg Ala Gln Leu Asp Thr Lys Thr 
     690                695                700
Asp Ser Thr Gly Thr His Ser Leu Tyr Thr Thr Tyr Lys Asp Tyr Glu 
 705                710                715                720
Ile Met Phe His Val Ser Thr Met Leu Pro Tyr Thr Pro Asn Asn Lys 
                 725                730                735
Gln Gln Leu Leu Arg Lys Arg His Ile Gly Asn Asp Ile Val Thr Ile 
             740                745                750
Val Phe Gln Glu Pro Gly Ala Gln Pro Phe Ser Pro Lys Asn Ile Arg 
         755                760                765
Ser His Phe Gln His Val Phe Val Ile Val Arg Ala His Asn Pro Cys 
     770                775                780
Thr Glu Ser Val Cys Tyr Ser Val Ala Val Thr Arg Ser Arg Asp Val 
 785                790                795                800
Pro Ser Phe Gly Pro Pro Ile Pro Lys Gly Val Thr Phe Pro Lys Ser 
                 805                810                815
Asn Val Phe Arg Asp Phe Leu Leu Ala Lys Val Ile Asn Ala Glu Asn 
             820                825                830
Ala Ala His Lys Ser Glu Lys Phe Arg Ala Met Ala Thr Arg Thr Arg 
         835                840                845
Gln Glu Tyr Leu Lys Asp Leu Ala Glu Lys Asn Val Thr Asn Thr Pro 
     850                855                860
Ile Asp Pro Ser Gly Lys Phe Pro Phe Ile Ser Leu Ala Ser Lys Lys 
 865                870                875                880
Lys Glu Lys Ser Lys Pro Tyr Pro Gly Ala Glu Leu Ser Ser Met Gly 
                 885                890                895
Ala Ile Val Trp Ala Val Arg Ala Lys Asp Tyr Asn Lys Ala Met Glu 
             900                905                910
Phe Asp Cys Leu Leu Gly Ile Ser Asn Glu Phe Ile Val Leu Ile Glu 
         915                920                925
Gln Glu Thr Lys Ser Val Val Phe Asn Cys Ser Cys Arg Asp Val Ile 
     930                935                940
Gly Trp Thr Ser Ser Asp Ser Ser Leu Lys Ile Phe Tyr Glu Arg Gly 
 945                950                955                960
Glu Cys Ile Ser Val Glu Ser Phe Met Ser Ser Glu Asp Ile Lys Glu 
                 965                970                975
Ile Val Lys Arg Leu Gln Phe Val Ser Lys Gly Cys Glu Ser Val Glu 
             980                985                990
Met Thr Leu Arg Arg Asn Gly Leu Gly Gln Leu Gly Phe His Val Asn 
         995                1000                1005
Tyr Glu Gly Ile Val Ala Asp Val Glu Pro Tyr Gly Tyr Ala Trp Gln 
     1010                1015                1020
Ala Gly Leu Lys Gln Gly Ser Arg Leu Val Glu Ile Cys Lys Val Ala 
 1025                1030                1035                1040
Val Ala Thr Leu Ser His Glu Gln Met Ile Asp Leu Leu Arg Thr Ser 
                 1045                1050                1055
Val Thr Val Lys Val Val Ile Ile Pro Pro His Asp Asp Cys Thr Pro 
             1060                1065                1070
Arg Arg Ser Cys Ser Glu Thr Tyr Arg Met Pro Val Met Glu Tyr Lys 
         1075                1080                1085
Met Asn Glu Gly Val Ser Tyr Glu Tyr Lys Phe Pro Phe Arg Ser Asn 
     1090                1095                1100
Asn Lys Trp Gln Arg Asn Ala Gly Lys Gly Ala His Ser Pro Gln Val 
 1105                1110                1115                1120
Pro Leu Gln Leu Gln Ser Pro Met Ile Ser Arg Val Asn Ala Gly Lys 
                 1125                1130                1135
Gly Asp Gly Lys Met Pro Leu Pro Glu Arg Ala Ala Asn Ile Pro Arg 
             1140                1145                1150
Ser Ile Ser Ser Asp Gly Arg Pro Leu Glu Arg Arg Leu Ser Pro Gly 
         1155                1160                1165
Ser Asp Ile Tyr Val Thr Val Ser Ser Met Ala Leu Ala Arg Ser Gln 
     1170                1175                1180
Cys Arg Asn Ser Pro Ser Asn Leu Ser Ser Ser Ser Glu Thr Gly Ser 
 1185                1190                1195                1200
Gly Gly Gly Thr Tyr Arg Gln Lys Ser Met Pro Glu Gly Phe Gly Val 
                 1205                1210                1215
Ser Arg Arg Ser Pro Ala Ser Ile Asp Arg Gln Asn Thr Gln Ser Asp 
             1220                1225                1230
Ile Gly Gly Ser Gly Lys Ser Thr Pro Ser Trp Gln Arg Ser Glu Asp 
         1235                1240                1245
Ser Leu Ala Asp Gln Met Glu Pro Thr Cys His Leu Pro Ala Val Ser 
     1250                1255                1260
Lys Val Leu Pro Ala Phe Arg Glu Ser Pro Ser Gly Arg Leu Met Arg 
 1265                1270                1275                1280
Gln Asp Pro Val Val His Leu Ser Pro Asn Lys Gln Gly His Ser Asp 
                 1285                1290                1295
Ser His Tyr Ser Ser His Ser Ser Ser Asn Thr Leu Ser Ser Asn Ala 
             1300                1305                1310
Ser Ser Ala His Ser Asp Glu Lys Trp Tyr Asp Gly Asp Arg Thr Glu 
         1315                1320                1325
Ser Asp Leu Asn Ser Tyr Asn Tyr Leu Gln Gly Thr Ser Ala Asp Ser 
     1330                1335                1340
Gly Ile Asp Thr Ala Ser Tyr Gly Leu Ser His Gly Ser Thr Ala Ser 
 1345                1350                1355                1360
Leu Gly Ala Ser Thr Ser Ser Pro Arg Ser Gly Pro Gly Lys Glu Lys 
                 1365                1370                1375
Val Ala Pro Leu Trp His Ser Ser Ser Glu Val Leu Ser Leu Ala Asp 
             1380                1385                1390
Arg Thr Leu Glu Thr Glu Gly His Gly Met Asp Arg Lys Thr Glu Ser 
         1395                1400                1405
Ser Leu Ser Leu Asp Ile His Ser Lys Ser Gln Gly Gly Ser Ser Pro 
     1410                1415                1420
Leu Thr Arg Glu Asn Ser Thr Phe Ser Ile Asn Asp Ala Thr Ser His 
 1425                1430                1435                1440
Thr Ser Thr Met Ser Ser Arg His Ser Ala Ser Pro Val Val Phe Ser 
                 1445                1450                1455
Ser Ala Arg Ser Ser Pro Lys Glu Glu Leu His Pro Thr Thr Ser Ser 
             1460                1465                1470
Gln Leu Ala Pro Ser Phe Ser Ser Ser Ser Ser Ser Ser Ser Gly Pro 
         1475                1480                1485
Arg Thr Phe Tyr Pro Arg Gln Gly Ala Thr Ser Lys Tyr Leu Ile Gly 
     1490                1495                1500
Trp Lys Lys Pro Glu Gly Thr Ile Asn Ser Val Gly Phe Met Asp Thr 
 1505                1510                1515                1520
Arg Lys Arg His Gln Ser Asp Gly Asn Glu Ile Ala His Thr Arg Leu 
                 1525                1530                1535
Arg Ala Ser Thr Arg Asp Leu Arg Ala Ser Pro Lys Pro Thr Ser Lys 
             1540                1545                1550
Ser Thr Ile Glu Glu Asp Leu Lys Lys Leu Ile Asp Leu Glu Ser Pro 
         1555                1560                1565
Thr Pro Glu Ser Gln Lys Asn Phe Lys Phe His Gly Leu Ser Ser Pro 
     1570                1575                1580
Gln Ser Pro Phe Pro Ser Thr Pro Thr Ser Arg Arg Ala Leu His Arg 
 1585                1590                1595                1600
Thr Leu Ser Asp Glu Ser Ile Tyr Ser Ser Gln Arg Glu His Phe Phe 
                 1605                1610                1615
Thr Ser Arg Ala Ser Leu Leu Asp Gln Ala Leu Pro Asn Asp Val Phe 
             1620                1625                1630
Phe Ser Ser Thr Tyr Pro Ser Leu Pro Lys Ser Leu Pro Leu Arg Arg 
         1635                1640                1645
Pro Ser Tyr Thr Leu Gly Met Lys Ser Leu His Gly Glu Phe Phe Ala 
     1650                1655                1660
Ser Asp Ser Ser Leu Thr Asp Ile Gln Glu Thr Arg Arg Gln Pro Ile 
 1665                1670                1675                1680
Pro Asp Pro Gly Leu Met Pro Leu Pro Asp Thr Ala Ser Asp Leu Asp 
                 1685                1690                1695
Trp Ser Asn Leu Val Asp Ala Ala Lys Ala Tyr Glu Val Gln Arg Ala 
             1700                1705                1710
Ser Phe Phe Ala Ala Ser Asp Glu Asn His Arg Pro Leu Ser Ala Ala 
         1715                1720                1725
Ser Asn Ser Asp Gln Leu Glu Glu Gln Ala Leu Val Gln Met Lys Ser 
     1730                1735                1740
Tyr Ser Ser Ser Lys Asp Ser Ser Pro Thr Leu Ala Ser Lys Val Asp 
 1745                1750                1755                1760
Gln Leu Glu Gly Met Leu Lys Met Leu Arg Glu Asp Leu Lys Lys Glu 
                 1765                1770                1775
Lys Glu Asp Lys Ala His Leu Gln Ala Glu Val Glu His Leu Arg Glu 
             1780                1785                1790
Asp Asn Leu Arg Leu Gln Glu Glu Ser Gln Asn Ala Ser Asp Lys Leu 
         1795                1800                1805
Lys Lys Phe Thr Glu Trp Val Phe Asn Thr Ile Asp Met Ser 
     1810                1815                1820



<210> 578
<211> 31737
<212> DNA
<213> Homo sapiens
<308> AC004974
<400> 578

gatctctta  ctgttgttt  ttgttgggt  tgtatggca  catggtaga  acatggaac  60
taatttcat  atctttgta  gttgtgtac  gagaatggg  tccagtgga  tcagctaca  120
ttaaaaaaa  tataatgat  agatgacta  aacaggaaa  ataatttat  taagagaaa  180
atctcaaaa  agaaaagag  agaaaagaa  atgatttag  atgaaaaga  tctagacaa  240
acaggtgtt  ttccttttt  tttttgtat  tgatcctct  tggcagtct  gtgaagcct  300
cggatcaga  cccttctca  aataatatt  gtaaaagta  aaaataaaa  acataagat  360
tcaaaagaa  ttatatcga  gcgcacagt  tcaaataat  ttaaatatg  atgcacaag  420
tttatataa  aagatttag  agttggtct  atatctact  taatgctga  gacatgatg  480
gcacaaaca  tcttgagat  tctgcaaca  caaataata  aatacgaaa  tatctgtgc  540
ttctattgg  aatgaaatc  caggtaaat  aattactgt  gtttactgc  tatggccat  600
atgaacaga  atgctaaat  tcaacttgg  gtcagtgaa  ataaagaaa  tcttatttc  660
catccaagt  cacagaccc  tgaattctg  cgacacatc  agttaggaa  catttttct  720
atacttcca  ttcaagcaa  agacttgtt  tgttcttaa  aaaaaaaaa  aagacaata  780
tttaacaag  ccattaaca  tgaagaaca  agttgacac  gcaacgtct  acaattttt  840
taagactta  gcatgttgt  ttctcactt  ccttaagaa  aaaaaaacc  ctactgcct  900
tatcttaac  aagtttcag  atcagtgtt  ccacaagta  ctggaagct  cagaaaaaa  960
ttattaact  cccaactca  agggaatac  tgtttagac  caaaggatc  ggacttagg  1020
gttgcaaaa  gaacagaag  acattcact  taggtaaac  caaccctct  tcaacccaa  1080
ttttttttt  ttttttttt  tgagacagt  tcactctgt  gcccaggct  gagtacaat  1140
gtgcgatct  ggctcactg  aacctctgc  tcctgggtt  aagcgattc  cctgcctca  1200
cctcctgag  agctgggac  ataagtgca  gccaccatg  ctggctaat  tttgtagtt  1260
tagtagaga  ggggtttca  catgttggc  aggatggtc  caatctcct  accttgtga  1320
ccacccacc  tggcctccc  aagtgctgg  attacaggc  tgacccaac  tacctggcc  1380
cgaccctat  ttttgagga  caaaacact  gatggcatt  tagagaacg  tgctctcag  1440
caaagtctc  gacacatac  aaaaggcaa  agtagttct  aaaacttag  atgcacagc  1500
tcagctgtg  agctaaatt  agaggcaga  tcccagggc  cacccccca  aatactcct  1560
agtgggtat  gggcctcac  ggggaatct  ttcttcaca  acactccca  gtagctcta  1620
tgcagtaac  ccgctgccg  taggtactg  tctaagaat  gactacaac  gtggcttgc  1680
gacagcttt  taaagatat  ctagagctc  gagtttcaa  cttgagctt  ttggagaat  1740
ttaattttg  agctgacat  aaatgcgaa  gcttaaaaa  agtcaaaaa  agaacaaag  1800
aaagactac  tttcaaaaa  tggaaaact  tgtaacaac  tataaatat  caagaaaaa  1860
atcttctaa  tattaatga  catcacaac  aaaaaactg  gtattacta  aacaaagga  1920
tcaactgaa  tatttaaga  aggtcttga  cgtgaagaa  ttatctatt  tcaagaacc  1980
tttctataa  tatgtatag  acagatcag  acattttaa  actttaaag  gaatgtgtc  2040
ccactgacg  gtacttata  atgtgtttc  agtcaattt  aagcaaaat  aatgaaaca  2100
aaaaaaaaa  tgtcattgg  attcattta  tacactgtg  tttatatgc  tgctagttc  2160
aaaaggatt  ctgccagag  ggaaaactg  tggggaaga  aacactgaa  atcatttat  2220
tttctactt  tagcccctt  tctctgtcc  ccacgtctc  tttcacaca  tgtatgcta  2280
ctgaccagc  tttttctga  gtcttttag  ttcatagag  tttgctgat  attttcaac  2340
gtttgggaa  agtttcaga  gtttcagag  tgaaactag  gctaaaata  tgaaacttt  2400
ctttccaag  agaaaagaa  tccaaaatc  tgaaattac  atgcacttc  tagaggtat  2460
aaactttac  agaaagaat  aaaaaagaa  gtttgctat  aagaaataa  taacagagt  2520
aacagacaa  ctacagaat  ggagaaaat  tttgcaaac  atataccca  caaaagact  2580
atatccaga  tctctaaga  acttaagca  atcaacaag  aaaaaacaa  cagccccat  2640
aaaaagtgg  taaataaca  aaatagaca  ttctcaaaa  aagacatac  cgtagccaa  2700
aaacatgaa  aaatgctca  catcactaa  cactggaga  atgtacatt  aaaccacaa  2760
gagatacca  ctgatatca  acagaatgg  tatcattca  aagtcaaaa  ataacagat  2820
ttggcaagg  ttttgagaa  agaaaatat  catacactg  tcatgggaa  gtaaattaa  2880
acagccact  tggaaaaca  tatggagat  tctcaaaga  ctaacaata  aactaccat  2940
tgacccagc  gtctcccta  tgggtatct  ctcaaagga  aagaaataa  tttatcaaa  3000
ggcacctgc  ctaatttgt  tattgcagc  ctgttcaca  tagcaaagg  atggaatcg  3060
cctaagtgt  tatcaatgg  agactggat  aaggaaaca  ggtacatat  catcatgga  3120
tggtacgca  ccataaaaa  gaacatcat  atctccctg  caacaacac  catgcagct  3180
gaggccatt  tcctaagtg  attaacgca  aaacagaaa  tcaaatact  catgttttc  3240
cttacaagc  ggagctaaa  aatgggtac  catgaacat  aagatgaaa  caacagaca  3300
tggcgagtc  aaaagtggg  aggaaggtt  agaggaagg  ttggagaac  ctactccac  3360
tcaaaatct  cacctactg  gtactatgc  cactatttg  ctaatagat  cactagaag  3420
tcaagcccc  gcattatgc  atatacccc  gttaacaaa  ctggacatg  cctcccgaa  3480
ctaagactg  ttactatat  actaaggaa  aaagcatcc  atgctctta  tataatatt  3540
ttagtgacc  tgaaaccct  aaactatga  agttttaat  gaatgacta  caggaaaat  3600
aaaaaaaaa  tgctttttt  tctggttga  gagcgtatt  agcaactct  aagggacaa  3660
gtgcttgta  aaggaggat  aaagaatga  gctacttca  atttgtata  agctttaat  3720
aataagtaa  ttcaggcat  atataggtc  ccttgacaa  cacatgatc  gcctccttg  3780
caatcacat  atctgcctc  aaatctttc  ttatgaaaa  tcttatatc  cttttaaga  3840
cttgaacct  aactgcatt  ataacactg  tgaaaaatg  aggagaaaa  aaacagtca  3900
taacattgc  gcaaattaa  gaaggcagg  ctttgaagg  aagctttta  aaacggctt  3960
taagtctcc  gtgtactga  gtgacaaac  agcctcagt  aggaaataa  tcccccaaa  4020
aatccacgt  cgtagctaa  aatgaggat  gtctccagc  ttcaaataa  aaactgctt  4080
gtgggaagt  tattgtatt  attgtagtg  gagagaatg  taattatct  ggttatatc  4140
tccaaataa  aaaacaaaa  agaaggaaa  atcccctat  aaaaatttc  tcattgcag  4200
attgttcca  cctgtgaca  atttatttg  agcttgctt  tttgctaca  atccttatt  4260
ttgaaatgt  tagatggtc  ttgcacaga  aactgggaa  aagaagaaa  ggttcaata  4320
ttcattact  ccctgagcc  cgtcctcct  tacaaaaat  ctaagaaat  aatatgatg  4380
taatgcatg  agtagagct  tctcatgag  tggtttgag  actgttagc  caagggctt  4440
agagggagg  agacatagg  taaaggccg  tcttggggc  ttgctatac  tcattctac  4500
tttatgctt  ctctgaaca  ttcattaac  acactactg  gatctattc  actttccta  4560
tgcttgcta  ctatctaac  atgggcatg  tacttaatc  aaagaagcc  attctgtaa  4620
gtggggata  ttggtatct  gcaggtttg  cggaattaa  cgagacggc  tacatatca  4680
aagtatctg  gacttctgc  tccagccat  atgaagtgc  tgatacagc  cttaccatg  4740
cattgtgaa  aactagaaa  aatgatata  tagctgaaa  aactgtttg  agacattgg  4800
gaacaggca  ccttggata  tgatccttg  gaaaaaaga  tacagaaga  gagccctat  4860
acccctggg  tttctacct  gaggtactt  tgggacagt  gacacagag  aaggtactg  4920
agggggaag  caagacaga  tcgagttca  gaagtctga  gtgactgat  tttgctagg  4980
agaatacca  agagaaaga  atatcagat  aaaggttca  aaatctgaa  aggggtccc  5040
ttgagtctt  agttggaca  taagctgca  atgcatatg  ataaattcc  aaagccaag  5100
aaagacaaa  tattaggga  agaacaact  ccaacgaat  ataagccaa  caattccac  5160
gttcacact  ggttgggag  cattaatga  ttctgaaca  ccacagtag  cacttcatt  5220
aatattcaa  tactgaggt  caagaaaag  catgcctta  tagtagggc  aagttagcc  5280
gagtaaaag  tactctagg  atgctttaa  aaagcttaa  aataagact  ataaaaatc  5340
agctgttct  caacttcac  gcctgccaa  acaaaactc  acacttaaa  aagataaca  5400
aattaagac  ctgaacaat  aaacattta  aatatccaa  atcttatca  aaacaacca  5460
acatgtgag  aagtaaaat  tatacaaag  aaccccatt  aaaaaagaa  ctgaaaatg  5520
gagaaatga  gaaattagc  gatgaacat  ttgaaacaa  tattataaa  gtgtttagg  5580
atctaaagg  cagcgtgaa  ctaaaaagg  gagaataga  gacatttaa  aagattatc  5640
aatgcaact  ttggccctg  aatataata  cttaaatgg  aatttcact  gacgggatt  5700
acaatgaat  aagatacca  ggaagaaaa  aaaaacaca  ggagcttta  gatatatta  5760
tagaaatta  ccaaactga  gcacagaag  aaaaaaaaa  gttaggggg  aaaaaaaaa  5820
aaccagggc  tcattaacc  gtggtacac  agtgagtga  ataacatat  tgtaattgg  5880
gtctcagag  gatgggagg  taagacaga  aaaataaag  aataacagc  gatagtact  5940
taatttgat  aaaactaca  acccataga  tcaagtgac  tctacagtg  gaatgatcc  6000
tgaacattt  ttctgaaaa  cactttttt  gaaaaagaa  tatattcaa  gtttcttga  6060
acaacataa  gttagatta  gtatggtga  attacatca  agcacacag  acgaagtct  6120
atctctagt  gtgtccagc  cagtaggag  cagctgagg  gtacagagg  tggctgttg  6180
ctattttgg  ggtctatga  tatttaatg  aggtttaaa  ggcatagtg  atagactct  6240
gtttttgcc  ctattaata  gcttggagt  aaagagatg  ttttgcgta  tgtcttctt  6300
ggggcttca  agtaggaat  cttccctac  tttcgttca  tttaggaaa  gcgacattt  6360
aaaaggaca  aaggattct  tgaatcctt  tcaggaaat  tgccctgaa  ggtcagaca  6420
gcctcataa  gttgaacta  ttaaaggag  gtagttcag  gaaaaagaa  ctttccctg  6480
tgaaggtat  atataattc  aaaactaca  taagaggct  tttggtaat  caggctcat  6540
cccctctag  ctttgcagt  gttgggata  ttggacaaa  tgtgcacaa  gtgcttatt  6600
tgtgtattc  actgcctta  tacatgtca  gttgcttaa  gatacccta  ctatacatt  6660
ctcacatca  ccttcatca  agataacac  caatcttat  aactcccag  ctgaccatt  6720
atttatagt  tcactgagc  tattacaca  tctcttccc  gatcctttc  ataactgtt  6780
gtggtagtg  taatttata  agcacaaca  atgggggca  catgaatga  ctgtaccag  6840
tgaatatca  aatagctgg  taaaaagag  ttaaggaca  actgaaatt  aacatcttt  6900
tgcagttgc  agcagagta  agaatgtta  aataatatt  aagcagcta  gctatttat  6960
ggttttaat  gtctctctt  catgtcgtt  ccaagttgg  aacagcaaa  ccatggcaa  7020
aggaaattc  tccctgcag  ggagtttat  aatgctttt  tgttttcat  actcaactc  7080
ttatttaat  tcctgtaca  aaaatcaga  agattacta  agactgcaa  acagatgtg  7140
taatcccaa  accctctca  agaaaaaca  gtcacaggt  tctatggat  aatttaaag  7200
taaaattta  aactgcttt  acacagaca  atagcaaaa  tcaacacac  ctttgatta  7260
tcccagcta  ccaaaatag  catttgaga  tgttaacta  tttactgac  acttgggga  7320
tggacatgg  caacctttt  ggttcatgc  ccatagtta  acagattgt  tcattatca  7380
gcttttaat  aacacattt  atgagctaa  ctaatacca  agctaaaaa  cctattttc  7440
cagagatta  gtagactgt  aataataat  atagaaaca  aaaccctag  tgtaaaaag  7500
atacaaaaa  acaaaaaca  aggctgact  catagataa  catgaagac  atgaaatga  7560
ttaatggaa  tcaaaaatt  caggcttac  ctcagacag  tgtaagttt  cggagtttt  7620
aatcaccct  acatttggc  aaatgtaat  aaatttaca  aatgctcac  caggagcaa  7680
tctgcacga  ctgtgtcac  gccccactc  atgcacaca  ctctgacaa  actattttt  7740
tagagtcta  ttctagcta  tttggttat  atcttcaac  gttctggtg  tacatcctc  7800
ctctctggc  ttctctccc  catcaccag  agtgttctg  gataaatgg  aatgttgct  7860
tacggataa  ttagcagat  cacaacagc  caacagggg  aaaataagc  tagtaggag  7920
gtgtaagta  ttcttactt  tggtatcaa  ctgtgctcg  tacttctca  atcctttga  7980
ccgaactcg  tctcccaat  gttgaagaa  ttcttcaaa  gctgggcca  ctgactcat  8040
gttgtacat  tcttcttca  tgctctgtc  agctttgca  tacatgatg  ctactttct  8100
ctggtagtt  agctgtgaa  gcaggtaat  cgatgcata  aaatatagg  agatccact  8160
tgtcccagt  aaatgctaa  aggtcctat  gggcacatg  ccagaaaat  gctaacacc  8220
ttcttctct  gaaatcctt  tgtattttc  gtctttgat  caaaattaa  tggagcaag  8280
atctacgaa  ttcatgaac  gagaaaagg  cagaaaaat  aatgaaaat  tcctgtatg  8340
aaagatcat  caccattaa  cagatctgt  ggtactata  gaaatttct  ttaatcaat  8400
acaaagtac  aaatgaggt  attaaaaaa  cctggtaac  aaaggcaat  cttttttta  8460
ggtgtcccc  cttttaaaa  ggaggtctt  acaaattta  aagcagagg  ctactttat  8520
aaacatatt  taaaataaa  tgttttgca  taaaaggtc  actaatatt  ttgcagttt  8580
ttttttgta  aattagaaa  gacttatct  ccaataccc  tttcccaat  tattaaatt  8640
taaaccttg  ctatatctt  gttacagca  tactatcat  aatactgta  ttagagcaa  8700
ttctctttc  aatagtttt  caaaggatg  gtgtctgca  agaaacttt  aaagaggcc  8760
cacaatggc  aatcagcta  tggcaaata  ttcttcctc  aatgcagtt  aaatgaagg  8820
ttaagagat  tacttataa  attaatcaa  acatttatt  atcattgaa  agtccagtc  8880
ttttgcaaa  aaattttaa  gtgttactg  tcatttaac  agcaatgag  tttcaacat  8940
aaaatgtgt  ctttgggct  ggcacagtg  ctaatgcct  taatcccag  actttggga  9000
gctgagggg  gcagatcac  tgaacctag  agttccaga  aagcctggg  aacatggca  9060
aaccctgtc  ctacaaaat  tacaaaaat  agccaggtg  ggtggtgca  acttgtagt  9120
ccagctact  gggaggttg  ggttcgagg  tcatttgag  ccgggagat  gatgttgca  9180
tgagtcatg  ctgtaccac  tactccagc  tgggcaaca  agcaaaact  tgtctcaaa  9240
aaaaaaaaa  aaaaaaatt  gactttgaa  tctccaatg  cattgggac  attcttatc  9300
cttaatcct  tttccagag  gtcattaca  ccaccacat  agtaaggtt  tatctaata  9360
aagggggaa  agaagaggt  aaattttaa  agctaacat  tattgaata  ctatcatat  9420
ccaggcact  cgtgcagtg  ttaacatac  ttaaattct  actctcaca  tagcccaca  9480
ggcaaatat  acccctgtt  gacagatga  caaagagat  agagaatgc  agagagagg  9540
actagtaca  tagggagag  cacaagatc  taaagagtc  gttctgtga  tcagctcca  9600
taactatca  cagaactca  ccaggtttg  ctttggaca  ccgctgcaa  atatgtcta  9660
aacttctta  ttgcaattc  gaagttgaa  ggtagaaag  aaatttagg  aaacatatt  9720
ggcagcaaa  cttgacatg  ggctgacat  agtactttt  atttattca  ctttgtgtg  9780
atattcatg  ttcccctgc  taattgatt  tggggtact  ccccagatc  cactgggaa  9840
attactata  gggtcatac  ttttattat  cctctaaaa  ctgaaaatt  ctcaattct  9900
aaacacagc  agccctgcc  ctttatatt  agggactac  aacctgaac  accattttc  9960
gctttccaa  tcaaatggt  caaatcgtg  taacggaaa  tgtcacagg  gagaaaaca  10020
atgaacaaa  aaaaaaaca  ctttgcttg  tttgtctcc  tcccctgca  cctgcttag  10080
tgacaagaa  gctcaacag  ctttgcatt  tgcatagac  ggagggttc  tggatatat  10140
tatatattt  tgagatgga  tttcgcttc  ctcttgttg  ccaggcggg  ttgcaatgg  10200
gcaatcttg  ctcactgca  cctccgcct  tggagttga  gcgattctc  ctcctcagc  10260
tcccaagta  ctggtatta  aggcatgcg  caccaggcc  ggctaattt  tgtattttt  10320
gtagagatg  ggtttcacc  tgttggtca  gctggtctt  aactcctga  ctcaggtga  10380
ccacctgcc  cggcctccc  aagtgctgg  attacaggc  tgagccact  tgcctgtcc  10440
ggaatattt  taaaacagc  tacaatctg  cctactgct  ccttgatta  gaacaggca  10500
acattcggg  cttagttca  ttttgtata  cacacataa  aaaaaaaaa  cagggtaaa  10560
cttgctgca  actactgac  tttaacccc  ttcttagcg  gcctgcttc  aatggctga  10620
tgtggctaa  gcttagaag  gaacgctcc  acaggtaaa  gtttcatct  ggctttaga  10680
ttgagctaa  taccctatt  ggtctcaac  aataaaaag  gagagatag  ctcgatgtc  10740
attacaaaa  aagtcctta  tacagccag  ttccagggc  gaacattac  tgactctct  10800
cctccaggg  gaacaaaaa  atcaagcaa  ctgtagaca  gaaggggct  taagttaca  10860
gctgtctgg  tatgccttc  agaacagcc  tcgcttgca  cagggtaaa  caaaactca  10920
cctgactaa  ggaaagcat  acagcgaca  tgaatttgt  ggtgcctat  taaaacttc  10980
tagatagag  cctaagatt  cactgtgca  cactcaaaa  gattaattt  tttagattc  11040
tttattaaa  aaaaaaaag  ttcctgcag  aagaagata  gaaaacatc  cccaaagta  11100
tggacaagc  gaattcaag  acaggacaa  gtgcctctt  tgactgaat  ctataccct  11160
gtgagctcc  cctgctgac  gaacaaacc  gttttgcca  ttgtgaaag  aatgatcct  11220
taagaggat  aggaaattc  ttacaatgt  aagtttcct  tggtttgaa  ctgtgtcaa  11280
tatcacttg  tgtatcctc  aaggtgaca  tgtgactgt  tcttgattt  tactccaat  11340
agatcaaag  taggtagca  tctccgaac  caggctcct  gaatcctta  cagccatgc  11400
cccagatag  atgagatgt  gacaagcag  agttaagta  atgtaatca  gaacattct  11460
agagaagga  ctaatgtac  tggagttgt  aagccatga  gtggggatt  tggattgct  11520
tgaggttat  taaaacagt  tttattgtc  cagaaacac  caaacatac  tacgtgggc  11580
tatggatct  catatacaa  actttaagg  aatgatcaa  atagagtta  gatgacacc  11640
gaagccctc  tatccacag  ttagcattt  gctttggat  acctctggg  catttagca  11700
tggtaccat  attcatgcc  gcagatcag  tgttcatat  aagcactga  ggaagtgct  11760
ggcactcaa  aaatgtttg  acatacaaa  gtgatggtg  tcagtccaa  gggacaagg  11820
ctatatttg  gatgaaggt  ttaaatctc  acaaagtaa  ggggtcttt  aacacttac  11880
aaaagtgtt  tgagcttcc  cagctggga  acaacagta  ataaatttg  tcttcctct  11940
atacaatag  cactttaac  cagagttaa  aaacagaca  tgcaggctc  cgcctgtaa  12000
cccagcact  tgggaggcc  aggcgggtg  ctcatgagg  caggagatt  agagcatcc  12060
gactaacac  gtgaaaccc  gtctctact  aaaatacaa  aaattagcc  ggcgtggtg  12120
cgggcacct  tagtcccag  tactcggga  gctgaggca  gagaatggc  tgaacccgg  12180
aggctgagc  tgcagtgag  cgagatagc  ccactgcac  ccagcctgg  agacggagc  12240
agactccgt  tcaaaaaaa  aaaaaaaag  agaaagaaa  aaacagaca  tgcaatctg  12300
cttaaacag  cataacttc  tggaaagat  gacgataaa  tcacagccc  gtaccagaa  12360
aaagagatg  gaataacca  gttctcagt  ttcttcaga  gttttgcat  ttacctcat  12420
ttccctggt  tcatggcca  aaagcggcc  ctggggtag  acaaacgat  agaacaact  12480
aattcttac  ttcttatga  acctctact  ttgcctaat  aaatttaga  atttaaaat  12540
gtcactatg  ggtatttca  tgtgcaaca  ttcttgaag  gtggactgt  aactcttga  12600
catctctga  aaccttctt  tggggagtg  tggatcatg  catcaaaac  atcttcaaa  12660
cactattaa  agtcaatct  gtattttcc  cggacatat  cactcatgg  gagtcaaac  12720
gctggcact  ttgcatgaa  caagcagtg  ctccaaact  taccagcac  ccttgcatt  12780
tttttctcc  ctatacact  accccttcc  caaataaaa  cccagttaa  aatgtcctt  12840
atgaagcag  aaaatatta  cttgtatta  atctagaca  ttgagtata  gctttttaa  12900
attccatgt  atgaaatgc  gcgtatata  aaagcatct  ttgcctact  aagtgcttt  12960
tgatagctt  ctcaaggaa  agcacttgt  caactgagt  gcaagatga  ctttgtgtc  13020
ttttcatag  agactggca  gcagagtaa  ttctcctca  acccaccta  ttcctaatc  13080
ctagatcct  tgaatacgt  atgttaatg  taaagggga  catagatta  agaaggact  13140
aagattgcc  attaacaga  ggggagagt  gccaggatt  tccagatgg  cccaataac  13200
gaaaggtcc  taaaagtgg  agaggaaga  aagatgatc  tcagaaaaa  acaacggag  13260
caaaagaga  aagacaatg  aggcagggt  aaagggagg  aacactgct  gctttggag  13320
tggaggaag  gccatgagc  aaggtgcac  ggcagccac  agaagttga  aaggccaaa  13380
acagattca  ccttagagc  cccggaaag  acacagttt  attttagcc  agtgacacc  13440
atatttaat  tttaactta  agaactgta  aataacaaa  ctatgttgt  ttaaggcac  13500
gagtaggag  aatttgtta  agcagcaat  aaaacctaa  taaaatcac  attttcata  13560
gaaagaaca  acaagagac  aactatagt  attcaggct  gtgtatttg  gagatattg  13620
cttgaaaat  taaagggga  cctgttact  caggaaaaa  aactcacag  atttcctga  13680
ataatagaa  ttaagctct  aagcaaaat  taaattttt  gaaacttac  cctatcacc  13740
tgagcctaa  ggtttccca  cacttaact  tttttctaa  aagatcaat  gaatatttt  13800
attattgta  actaaacaa  cacttataa  atctccata  gagaaccaa  ttttccaaa  13860
gactgctgt  tgaaattac  aaatcatgc  tgaataaaa  attcattca  ggccaggca  13920
ggtggttca  gcctgtaat  ctagcactt  gggaggcca  ggtgggagg  tcacttgag  13980
ccaggagtt  aagaccagc  agagcaaca  agtgagacc  tgtctctgt  aaattaaaa  14040
atcaggtgg  tatggtggc  tgggcttgc  gtcccagga  ttggaagct  aggtgggag  14100
atggcttaa  cccaagagg  caaggctat  gtgagccat  attacatga  tgtgccact  14160
cactccagc  tgggcaata  agtgcaacc  tgtctcaaa  aaaattaaa  aaaaaggaa  14220
agaaagatt  attcaaagt  catgaaagt  aatgaattt  tcatttaac  gaatgattt  14280
agattaact  atgatttca  attccacat  gctatcaac  tttaagaaa  taccatttg  14340
tggccaggc  tggtggctc  cgcctgtca  cccagcact  tgggaggcc  aggtgtgca  14400
atcacaagg  caggagttt  agaccagcc  gactaacat  gtgaaatcc  gtctctact  14460
aaaatacaa  atttagctg  gcgtggtgg  gggcgcctg  aatcccagc  acttaggag  14520
ctgaggcat  agaattgct  gaacctggg  ggcagaggt  gcagtgagc  aagatcgtg  14580
cactgcact  cagcctggg  gacagagtg  gactccatt  caaaagaaa  aaacacaca  14640
acaaaaact  ccacttgtt  agttttggt  ttatatcaa  ggaaaatat  cacaattat  14700
tgaaaaggc  gtatgaaag  ccttctttc  ccaagtaca  aaactctgt  aggacagat  14760
ttcttcatt  actccaacc  aaacaacat  ttgcagcag  ctgacagca  atgcacata  14820
gtgagtcca  gtgccttct  ttaagccag  cattaaaga  atctgcaaa  acgatactt  14880
ctttgcact  gtttttcat  ttagaaaac  tttttcaca  acatgttac  tatattaac  14940
tgtaaaatg  aatcatttt  tttaaaaat  acattttaa  atttgtttt  attgtaatg  15000
ggtaaacac  caaaaaagt  ttatgaaca  aagctcttt  ggatcttta  cttttaaaa  15060
ggtgaaggg  ctctgagac  taaacatct  agaactgta  tgctatgct  tcttctgga  15120
ttctctaac  actaaaaaa  tcatctaac  tttcctatg  tcattgttt  ttttgataa  15180
ctttcttct  aaaatcaag  tttttccct  tggctgctg  taggagttt  tctgtatca  15240
gggtttgaa  caatttgat  atgatatct  ttggtgtca  tttctgcat  cttcttatt  15300
ttagggctc  ttgagtttc  tgggtctgc  tgcatcata  gtggaaaat  tggaactat  15360
tcctcaact  ctttttcag  tagttccta  ctcctctgg  gtctccaat  atatgaata  15420
taggtcagg  gaagttgtc  cacagtata  tgatgttgg  ttttttgtt  ttttttttt  15480
ggcaattgt  tctattgct  tgtcatcaa  ttcactaat  ctttcttcg  caatgtcta  15540
tctgctgtt  attctgtcc  gtgtacttt  caactcaga  attgtagct  tcatatcca  15600
aaatacaaa  cttttcttt  tccagattt  tacttaatg  tcaatcttt  ctcctgctt  15660
ttaaacatt  aaaagacat  agagtcatt  ttgtggttt  aattgttta  ttattttat  15720
ccctcccca  ctataggtc  tatgctcct  cttgtagtt  ttaattaaa  gattgactg  15780
cagacatta  gaatattac  ttgttgggt  ctggatatt  ttgtattcc  ataaagtat  15840
tttgacttt  ttctggatt  atagttaaa  tacttggca  gagtttgag  cttgtagtt  15900
ttgctttta  actcttggt  gtacgacag  agtgtttag  ctaaggata  ttctgcccc  15960
ctattgagg  aaaagcatt  tgaggctct  ctcaatgcc  tgtcaatta  gaagttttc  16020
agtctggtt  gtaggagtt  aaactattc  caccagagg  agactgttt  cggctctct  16080
ctccctgat  ctctgtgct  tgcgaattc  agcctccct  gactcacat  tcaatctca  16140
tcagggagg  ttctggcct  taactgggt  ccccctgcc  gtactgtag  ctggaaact  16200
tcttcaggc  gaaagctgg  gcaatctta  ggttcacct  atttgtttc  catctccca  16260
gcaatcaat  tccttcaat  cctgatgtc  aacattata  aaaccattg  ttcattgtt  16320
tgtctagtt  ttaagttgt  tcaggtgga  agttaaatg  agtccctct  acttaatct  16380
agcaagaag  agaaatttg  cttcagttt  taaatcaac  ttattgatg  atgatttct  16440
aagagtaaa  gcaaggcgt  taatttaat  acttctgac  aacccccaa  acaatcaaa  16500
tacagaaca  tgccattac  ccaatagct  ctggttcct  tttgcagtc  atccctgca  16560
catctaaca  cttcaggca  ccactgtac  aattttgtt  tttttacta  aaattagtt  16620
tgcctacat  ttaaagaaa  tttttggtg  aaaatccat  gtgagggtt  ctctttcag  16680
actttagaa  tgtcttctg  cttctactt  ttttgtttg  ttttgagac  gagtctcgc  16740
ctatcaccc  ggctggagt  cagtggctc  atctcggct  actgcaagc  ccgcctccc  16800
ggttcacac  attctcctg  ctcagcctc  agagtagct  gtactacag  aacctgcca  16860
cacacccag  taatttttt  gtgttttta  tagagatgg  gcttcactg  attagccag  16920
atggtctcg  tctcctgac  tcgtgatct  cccgcctcg  cctcccaaa  tgctgggat  16980
acaggcatg  gccaccacg  ccggcctct  ctttttctt  aggctttat  gcccagcaa  17040
tgtttaaca  tcttgttgt  ctttaaagg  atttttcca  ctggctatt  ttaaagatt  17100
ttctctttt  cttttattt  cagcaattt  tactatgag  ctatatttg  ttttttttt  17160
ttttttaga  tatcttgtt  agggtggac  gaactcctt  tttttatct  aatgcttgt  17220
tttcatcag  tctggaaat  tctaccagc  tttcctcaa  tactgcttt  attcccaaa  17280
aatgcataa  tatcttctc  tctggaaat  caatcatat  tatattttg  tgttaccca  17340
atgcctttc  gacattttt  tgtattttt  tatgttttc  tgtctccgt  ctttagtta  17400
aatttttct  gtaatctgt  ttcatcagt  ctctctcct  ctgtgtcca  tatgttctt  17460
aacatatct  cttttaaat  agtctaact  taggggttt  ttagtttta  agtttcaat  17520
taggctggg  gtggtggct  atgcctgta  tcccagcac  ttggaaggc  aaggcaggt  17580
gatcacttg  ggtcaggag  tcgagacca  cttggccaa  acagtgaaa  cccgtttct  17640
ctaaaaata  aaaagttag  cgggcgtag  ggcacacac  tgtaatccc  gctctgcgg  17700
aggctgagg  acaagaatc  cttaaactc  ggaggcgga  gttgcagtg  gccaagact  17760
caccactgc  ctccagcct  ggcaatagt  tgagactcc  tctcaaaga  gaagaaaaa  17820
aatgaattt  aatataatt  ttttacaga  ttgagttct  tagtaagcc  tgaattcaa  17880
ttgtaacct  caaagccct  tacaagctc  gatttgatc  gatcactga  agctctgat  17940
tgtctccta  ctttttatc  gctgcttta  gctagatgg  aaagcccca  gattcttaa  18000
ctatcagca  atgtctaag  gaaaaagca  tgtaagata  tgttaatct  gatagacta  18060
aatttctca  atttttttt  tctttctag  tcaagctct  ggtgccaca  ctaagaatt  18120
ttaaccaag  tgaaggtcc  aaagatttt  tcctatgtt  ttctcaaaa  aatttaata  18180
ttgtagatt  caatctatg  tccatttga  ttaattgtt  atgcttaaa  gtcaaggtt  18240
aggccgggg  cctggtggc  cacacctgt  atcccagca  tttgggagg  tgaggtggg  18300
agatcactt  agatcagga  tttgagacc  gcttggcca  catggtgaa  ccccgtctc  18360
actaaaaat  caaaaatta  ccgggtgtg  tggtatgca  ctgtaattc  agctactcg  18420
gagactgag  cacgagaat  gcttgaatc  gggaggcgg  ggttgcagt  agccaagat  18480
atgccactg  actccagcc  gggcaacag  gcaagactc  gtctcaaaa  aacaaaaaa  18540
caaaaaaac  caaaaagtc  aggttcatt  ttttgttta  ggatgtcca  ttgtcccag  18600
actgttgga  aagcctatc  ttcctccac  gaattactt  tacacctat  ccaaaaatg  18660
gctagatat  tttgtgtgg  gctatttct  gtttctcta  tctgttcca  cgatccaca  18720
gtctatctt  ccagcaatg  cacacagtc  tgactactg  agctatata  catgtcttg  18780
aatcagaca  aataacttc  cccacatta  ttcctcttt  tcagattgt  ttaggtatt  18840
cagttcctt  gttttttca  gtaaacttt  gaataatct  gtctataac  acaaaaaaa  18900
cttggcgga  ttttgataa  aattaagaa  ttaaacttt  tatcagttt  gagaacact  18960
acatgatta  tatatgtta  cgctctcaa  ttgtgaata  agtatgcct  tccatttat  19020
taggtcttt  gtttcttag  gacaggact  aatctgtca  ccaggctag  gtgtagcag  19080
atgatcata  ctcatggca  ccttgaaat  ctgggctca  gcgatcctc  tgccttagc  19140
tcctgagta  ttggagcta  aaatgcaca  caccatgcc  ggttaaatt  ttaaaattt  19200
tttgcagaa  caggatctc  ctatgttgc  caggctggc  ttgaactat  ggattcaag  19260
aatcctcct  ccttggcct  tcaaaacgc  aggattaca  aagtgagcc  tcatgccca  19320
cattagggt  ttgattcgt  catcagggt  ttgtagttt  caaaataca  gtcctattc  19380
tgttttgtt  gatgcatgc  caagctttt  tttatgttt  tagatgaca  ctcactgtg  19440
tgcctgggc  tgtcttgaa  tcctaggtt  aagtgatct  tctgcttcc  gactatctg  19500
gattatagg  acaggctat  atgtttggc  ccaagtttt  tttgtttgt  tagggattg  19560
aaatggtgt  ttttaattt  agtgtccac  tattcactg  aagaaatct  actgatttt  19620
gtaagttga  gttgaatca  acaagcttg  taaacacat  ttgcagttc  aggttgttt  19680
tctatagat  ccttagggt  ttgcaaaca  accagcatg  catctgaaa  agggagttt  19740
atttttcca  tgctgcgtc  acatgcctt  tcttttact  gccttactg  actgactag  19800
acttcttgt  ctatgttga  tagcagtgt  aacagcaca  atccttccc  ttctccagt  19860
tcttaccat  aagaataat  caagctata  aagttttgt  gatgttctt  atcaagctg  19920
gaaagttcc  ctgtattac  agtttttat  ataaataag  tcaaatttt  tcaaatgct  19980
tttctgcac  aattgatat  accacgtga  ttttcttct  tagtctgtt  gtacgatgg  20040
ctacattaa  tgatttttc  atactgaat  agccttgca  ctctagaat  aatccaact  20100
ggtcatggt  tacaaaatt  ttttctact  tattatatt  gctaatttt  ttttcaagg  20160
attttacat  tatattcat  agggatgtg  tcagtagtt  tcttttttc  tacctttgt  20220
tggctttgg  attagggct  cataaagtt  aatttaaaa  gtttcttat  ttgtatttt  20280
tggaagcaa  tgtgcagaa  tggtgataa  tctttaaat  ttaggtaga  ttcccagga  20340
aaccatctg  cccagtaga  ttcattttt  gagttttaa  attatgaat  caatttttt  20400
caataatca  agggctatt  aaatattct  tttcagtta  ctgagttgt  actgttttc  20460
gaggagttc  cccatttca  cttgtcaaa  ttgtatgta  tcagctgta  acagtattt  20520
tttaataca  tgttgctat  gggggcgtt  gtggtaata  ctaatttca  tcctgatag  20580
gtagtaccc  tgtattcat  agggatatg  tccaagacc  tcagtggat  cctgaaacc  20640
tggatagta  cgaacccta  ataactata  accatgttt  tccctctac  taaaaatct  20700
tgataaagt  cttattttt  tttttttaa  agtctcact  tgtcaacca  gctggagta  20760
agtggcttg  ccatggttc  ctgaagcct  caacttctg  acttaattg  tcctcctga  20820
tcagcctct  aactacaga  atgagccac  aagcctgga  acttttttt  taaattttt  20880
gtagagaca  tgtctcact  tgttgccca  gctaatgct  accttctgg  ctcaaatga  20940
cctcccacc  cagcctcct  agttgctga  attataggt  tgtcactgc  cccaactcg  21000
taaagttta  tttataaat  agacatagt  agaaattaa  aactagtta  aaaatagaa  21060
gattatgac  atacaatgt  ataaaagtt  agtgaatgt  caatgtact  tctctctct  21120
aaaatatct  attgtattg  actctccta  ttttagagc  cagttgact  cagaaagcg  21180
aaccatgaa  actgaggga  taccgtgtt  acaagattt  tattgtctg  ttttctttg  21240
cagtcttgt  agaggattt  caattttat  atcttttca  agatctagc  tgtgtgtgt  21300
tgtgtgcac  cgtgcacac  caggatctg  gttttatga  aaaaaaaaa  ttttttttt  21360
aaccccaaa  atgtagctg  ttttttttt  tttttaaag  tggagtctc  ttctgtcac  21420
caggctgga  tgcagtggc  ccatctcag  tcactgcga  ccctgcctc  cgggttcaa  21480
taattctcc  gcctcagcc  cttgagtag  tgagattac  ggcatgcac  accatgccc  21540
gctaatttt  gtatgttta  tagagtcgt  gtttcacca  gttggccag  ctggtctca  21600
gtgatccac  cacctgatc  caagtgatc  gcccacctc  gcctcccaa  gtgttggga  21660
tataggcgt  agccacctc  cctggccag  tctagcctt  catttcatt  atttcctca  21720
atgtttttc  atttttaat  tcattgatt  ctgatctat  ccatttcct  ctttctagt  21780
gctttggat  tattttgct  ttctctttc  agtcatata  ggttatgag  ttagattac  21840
ggtttgaga  gttttgtct  ttctaacgc  gcatttcat  ctgtcaatt  ccccctcag  21900
ctgctttaa  tgcatccca  aaagtttca  atgttgtct  ttcctttcc  ttcagttta  21960
atacatttt  tcatttccc  tgaagtgtt  tctttgacc  actggttac  tagaaatct  22020
tttttttag  ttccaagtg  ttagagatt  ttccattat  tttctgtta  ttctagttt  22080
attccagtt  gattagaaa  tatactttt  gttatttca  ttcttttaa  tttgaggat  22140
tttatttca  gggacagga  gtctatctt  gcatacatt  catgtgcaa  tgaaaagaa  22200
atgtattct  ctgttgtga  taaagtgct  tatgtcaat  agatcctat  ggttgatgt  22260
gtgaagttc  atgtctttg  tgattttct  tctagtttt  ctttccatt  ttgaaggag  22320
gatgttaaa  tcaccaact  taattgtgt  tttacctat  tctcctttt  gtttcatca  22380
tttttttcc  tcacattta  agctctgtt  gatgcacat  tacctagga  tgctgtctt  22440
ttggtggat  gacctcttc  tcattatgc  atgatcctc  ctgtctctg  taactttct  22500
tgctctgaa  tttacttta  ctgacatta  taagcccta  agctttcct  tgattcatg  22560
ttgcatggt  tttttccat  ctttccttt  aactactta  atttcaagt  actctatag  22620
ttatataat  agataatgc  ttttaaaat  cagtctacc  atctctgtc  tttaattgg  22680
atatttaga  cttttgctt  taatgaact  atttctgca  tagagttta  gtctgtcat  22740
ttatctttc  tttatttta  ctttctgag  attacttga  tgctcttta  aattctttt  22800
tgatttatc  atagggctt  tgaatgtat  tcttagaac  taagtatta  tagtgattg  22860
tctatgtat  actatatat  tctttatct  tgtagttga  atctacatg  accgtttta  22920
caattgaag  gaagtgtag  aactttacc  ctctttagt  tctttactc  ctgccattt  22980
taaaacact  acattaaaa  attcttgta  atatgtttg  aaagcacat  tgacattgt  23040
atagcattt  cttcaaatg  caaaataat  tagaaaact  attaagaaa  gtatttacc  23100
atattttta  tctttcctt  tctctgaag  tccaagatc  ctttttttc  gtttgtttg  23160
ttgttttga  atggagttt  gcttttgtt  cccaggctg  agtgcaatg  cgtgatctc  23220
gcttactgc  atgtccacc  cctgggttc  agtgattat  ttgcctcag  ctcccgagt  23280
cctgggatt  taggcaccc  ccatcacac  tggctaatt  tttgtattt  tagtagaga  23340
ggggtttca  catgttagg  aggctggtc  cgaactcct  atgtcaggt  acccacccg  23400
ctcggcctc  caaagtgct  ggattacag  tgtgagcca  cgtgccctc  caagatcca  23460
tcttttatc  cttcctttc  gtttagata  cttagctat  ttttttttt  tgagacgga  23520
tctcactct  ttgcccagg  tggagtgca  tggcacgat  tctgctcac  gcaagctcc  23580
cctcccagg  acccaccat  ctcctgcct  agcctcctg  gtagctggg  ctacaggct  23640
ctgccacca  gcctggcta  ttttttgta  ttttagtag  gatggggtt  caccatgtt  23700
gccaggatg  tcttgatct  ctgaccttg  gatccaccc  cctaagcct  ccaaagtgc  23760
gggattaca  acgtgagcc  ccgcgcccg  ccaacttag  tacttttta  gggtaggtt  23820
cctggtaac  agttctctt  attttcctt  atctgagaa  gtctcaatt  cattcctga  23880
ggatattct  cctgaacac  gaattctgg  ttgacagtt  ttttcttcc  tctcctgaa  23940
aattatcat  ccacttcct  ctggcctcc  tgatttctg  taaaaaaaa  aaatctgtg  24000
ttcaaattg  tcttccctt  taggtgggt  ttttttttt  ttttgaaat  gagttttgt  24060
cttgtcacc  aggctggag  gcagtggcg  gatcttggc  cactacaac  tccgtctcc  24120
gggttcaag  aattctcct  cctcagcct  ccgagtagc  gggattaca  gtgcccgcc  24180
ccatgccca  ctgattttt  gtattttta  tagacacag  gtttcgcca  gttgggcag  24240
ctggtctca  actcccaac  tcaggtgat  cacctgcct  tgcctccca  agtgctggg  24300
ttacaggca  gagccaccg  gcccagccg  tcttccctt  taggtaaca  gtcatttat  24360
ttttgcttc  ttcaagttt  ttttttttt  gtatttagt  ttcaaaaat  ttactatga  24420
gtctcttgc  gtggacttc  ttggattta  actgtttgg  atttgctca  tttctgtca  24480
gtgtgggtt  acacctttg  ccaaatttg  gaaacttct  accaaatat  tctttgaat  24540
ctttttcaa  gcctgccat  tttctcctc  tcttccaag  cacaattgt  aaatatttt  24600
ttatagccc  acaaaccgt  aagctctgt  catttgttt  ccccagtct  ctctttgtt  24660
ctcagattt  gtgattcct  tttgtttta  cttcaagtt  actgatttt  tcctctgtc  24720
cttccattt  gtctctggg  acaggggct  ctagggtgt  tagcccatt  aagtacctt  24780
catttcaga  tttataatt  ttggtagac  gctaatggc  catattcag  gtccactag  24840
atcctaaaa  cctatctac  gagttttac  ttttgactg  tctattttt  agttctaac  24900
tttccattt  ttccttaat  ccttcaatt  tttgctaag  ctttctatt  tttcatttt  24960
aaaaatcat  cttgtggct  ggtgctgtg  ctcacgcct  taatcccag  actttggga  25020
gcctaggca  gaggatcat  aggtcaaga  atcgagacc  tcctagcca  catggtgaa  25080
ccccgtctc  actaaaaat  caaaaatta  ctgggcgtc  ctaataaaa  tacaaaaat  25140
ctaaaaata  acacattac  caggaggct  aggcaagag  atcgcttga  cccggaggg  25200
ggaggttgc  gtgagccga  atcaagcca  tgcactgca  cctggcgac  gagtgaggc  25260
ccatctcca  agaacagaa  agaacagaa  ataacataa  ataacataa  ataacataa  25320
ataacataa  ataacaatc  tgcttgtaa  tgctcattg  aacattttc  tgatggctg  25380
cagaaaatc  ttgttagat  attctaaca  ctgtgtcat  ttagtgttg  catgtgttg  25440
tcaaatttt  ccttaagtt  agattttcc  aattgttgg  ataagcagt  attttaaat  25500
caattttgg  cattttgga  attaactta  gagactctg  atcttattt  aatcctcta  25560
ttagcaggc  ttctttatt  ccattctgg  atggaaaaa  tgacactgc  aggtggggt  25620
gaacatcaa  ttccctcca  gacacctaa  ggaaagcaa  acctctgta  tgctaggca  25680
tggcaacaa  tccagctcc  tgctgagtc  ctcctgata  tgccctggt  ggtatcagg  25740
atgcatgat  actactccc  acgtggctt  cactgacac  ttggtaaga  gaccccgtt  25800
ttgctgggt  tgcaaaaat  tcctgactc  ccaccaggc  tcttctgat  ccacacagt  25860
gggagctgg  ggggcactt  attaccact  caccgtgat  aaagttcca  ttcctcact  25920
agccttctc  aacaatgcc  cagcaagga  tagggagga  ggaaggctg  gggtttttt  25980
ttgttgttg  tgttagctt  tttttgtac  gtgcagttg  agtagagag  ttcctgttt  26040
aaagttttc  aagtttgtt  tttttggtc  ttttgctaa  aagaacaga  atttggggg  26100
cattttggc  gtgcctata  gcatttcca  tttgctgac  tcttcagcc  aagactggg  26160
tatatgagc  aagagaaaa  ccagggacc  cacagctat  ccattccag  gatctcaag  26220
tccctaacc  gcctgctgc  tctctccac  tttcagatt  attttatgt  tgttttata  26280
atgtgtcca  ggttgttgg  tgtacctag  aggaagaac  cagagaaat  catctactc  26340
atctttcca  aatccagag  ccaaactta  ttttaaaaa  attttgttc  attttcctg  26400
ttattctca  tggatgggc  ggtctgcaa  aagcaactt  gccattact  aaagtaaag  26460
ccttggtca  taaaataaa  caaaaaaaa  tgttctaat  cacattatt  gctttgatt  26520
gttcttcat  tacataact  tcttaacta  ttcctgaag  taaatttct  tactgtcct  26580
caaaaagaa  gacaaagaa  ctggaaaaa  tccgtattg  gagcaaaaa  tgccagtta  26640
aaaatgtat  tcctcattg  gaattacta  caaaaatcc  actgtttta  aaaaatgac  26700
tatggatac  aaatagtaa  gttgtaaaa  gaaaaaacc  gacagatgc  ttcaaaatt  26760
tttatatat  agtacacag  catattcta  cctattttt  tctttggca  aatgtaaag  26820
aaataatcc  cacacaata  ttttaccta  taatgttat  gtgcaaaat  tctcacaaa  26880
ataaaaagt  tcatattgg  tattaagtt  ataataaag  tacctgatt  ttttgacat  26940
gagatgaat  tcaattcta  agaaaaagt  ttcattgca  tactgtttg  aagagaaaa  27000
gacttaaat  tacacatac  tgcccatca  tagagaaac  gatgaaata  actatggca  27060
agcagtaca  caaaatact  tgctactat  cagtagtaa  aatactggg  aacctttct  27120
tgtactgac  aaaaaaatc  caaaaatat  ttcctaaat  aaaaaagca  gtgtctaca  27180
cctgttata  cttgtataa  aaaggggtg  aatgcatgg  atactatgc  gccataaaa  27240
aggatgagt  catgtcctt  tcagggaca  ggatgaagc  ggaaaccat  attctcagc  27300
aactatcac  aggacagaa  accaaacac  gcatgttct  actcatagg  gggaactga  27360
caatgagaa  acatggaca  aaggtgggg  acatcacac  caggcctgt  aggggctgg  27420
gggctgggg  agggatagc  ttgggagaa  tgcctagta  aaatgacaa  ttgataggt  27480
cagcaaacc  acatggcac  tgtatacct  tgtaacaaa  cttcatgtt  tgcacatgt  27540
ccctagaac  taaagtata  atatatgta  atatataat  tataaaaga  aggggtgaa  27600
taaagctgc  tatgcatat  tggtggtat  tgcataatg  aacagaaat  cagaaactg  27660
ataatgaaa  agaaatact  caccttgta  ttaataagg  gattaacta  aaggcaggg  27720
agaaaaggg  cataggaac  ggtagaaat  gaacccctg  atgtaaaca  agtcatact  27780
ctttgattt  gggaccatt  gaaactatt  cctagttta  ataaatcct  taggaaaga  27840
attggttta  cttttattt  aaagctgaa  ttaaaacac  atccacaat  caaaatcca  27900
aagacaaat  tttgccacc  gttcctgca  ccttctgaa  cgtgatcca  gtcctcacg  27960
gtgatctta  tcttgctgt  ttctctcac  gcaaactgc  gtcctacca  agccgcatg  28020
cttccaaat  ctaatgcta  cagtcccat  aatcacaaa  tcttctcat  ggaagggac  28080
ctatcctgt  atccaatcc  gcctcagcc  ggcaaaaga  cagcgatag  ccagcacag  28140
gtgatcact  cttgtgaac  cacaagaca  agctacaga  gccactgat  tcttcccct  28200
actagatgg  catggtgga  atctccttc  tgaaaatgt  catacggat  caccagttg  28260
ctggaatca  tttggtagc  atctgaact  taaacatgc  ttagctaat  tcataatct  28320
agagacgat  aaaattcta  gaatggcaa  tgttctgcc  aagcttcat  tagagaaaa  28380
cagttttgg  aaaaatatt  cccctatgg  tcatttttc  aaactagct  cctgaatca  28440
agagaaaat  gctagtcaa  ctcatttat  ctcacaata  aataacgca  caaggcaat  28500
aataggcga  gtcagcaga  aatttcatt  atgtcctta  tcaaagggt  agtgctatt  28560
attaccaca  aaacattgc  catttcctt  tatccattc  tgagatatt  attgcagag  28620
taaattaaa  atgatcact  tctccctta  tctgacttt  ataacctga  ggataactt  28680
ttaaaattt  aaactcaat  aatattttc  tttcactgc  tttttaata  tctagaaaa  28740
cagtgaaga  tcatttagg  aaagtcact  ccatttaca  gaaacctga  atttcctaa  28800
gaaaacaga  ctaccaatt  tctctactg  aaactagca  ctgtacctt  aatatttat  28860
aaccagacc  attccaatt  tatttgggt  taacatatt  cactgaata  cgggcactg  28920
agtctgcag  aatataatt  cagtttctt  ttccattca  ggggaggga  aagaggaca  28980
ggtggctga  gtactggtt  agaatgcag  ctctagagt  tgagtgcct  gattcaaga  29040
cagcctgca  agactctaa  tgtgactgg  ctttgtgtc  cagtgctct  agctataaa  29100
caggaacaa  aatagtatc  aagcattct  aggattaat  aaaataatt  atggaaact  29160
tttcacaca  tgcctggcc  agtcactgt  aataaaaat  atctacttt  ggccaagag  29220
agtggctca  gcctgtaat  ccagcactt  gggaggctg  ggcaggcgg  ccacgaggt  29280
aggagatcg  gattatcct  gctaacacg  tggaacccc  tctctacta  aaatacaaa  29340
atttagctg  gcgtggtgg  gggtgcctg  agtcccagc  acttgggag  ctgaggcag  29400
agaatggcg  gaacctggg  ggtggagct  gcagtgagc  gagatcgca  cactgcatt  29460
cagcctggg  aacagagtg  gactccgtc  caaaaaaaa  atcatctac  tttattact  29520
ccttacatg  gcctcacac  cctgctcag  gggattcct  gctgcctca  gaacgcact  29580
tgtgcttct  tccttccga  tctcgttct  attgttctg  gtatggacc  cccaactgc  29640
tattccctg  cctgatgaa  tcttcttcc  ctccaaggc  catctcatt  tgatccagt  29700
aaccattat  acttgtccc  actggcttg  acctccatg  tctttgttt  caattctct  29760
attagattt  ttatattaa  cctgacatc  attacagta  tttatgacc  tgtctcctt  29820
atggataag  actatgtct  actagccta  tttgttctc  acagtattt  acaacctgc  29880
gagtcatac  taaaaagca  ttattggat  tgaaacagt  ctgcttact  gtgaaagtg  29940
gcataatgt  tcaactaca  cagaagctc  ctcatagga  atgtataaa  attaaatga  30000
ataatgtat  taaagggct  ctaacaagt  attatctta  tatcaacag  tcctatttc  30060
tcaacgttt  atcacatgc  cagcactgt  ctaagtgct  tacatgtgg  aacgcctta  30120
accagggct  gacataatc  tctttcatt  cccttgcac  gagtagatg  aatataggt  30180
tttttaaat  actgttgaa  aaaaatggc  ctgatatgg  aaatttaaa  gtatctgaa  30240
tttctacat  atttaaaag  tgacttgat  aaataacaa  attcctaat  cttcacagt  30300
tagtttttt  aattattta  ttttttaga  acgggggtc  cattatgtt  cccaggctg  30360
tctcgaact  ctgggctca  gcaatcctc  tgcctcagc  tcccaaagt  ctgggatta  30420
aggtgtgaa  cacatcacc  agcctacag  atagtttta  gcatcagaa  attccaata  30480
tctacactg  attcctagt  agaaattaa  aaaataaag  tgacagatt  ttaaaaaag  30540
aattaaaaa  aaagtaatt  gagatatgt  aatgggatc  tggaaatct  aaaattgaa  30600
agctgtatt  tgcaaattt  tatccagtg  tcagggcta  taagggatg  caggtaaga  30660
aaacagctc  gggaatttc  gtatgcctt  atccccttg  ctgtaaaat  ggccaatag  30720
tggaatcta  tgcacaggg  tgctgtgag  attaaatca  attatgcca  taaagtgat  30780
agaacatag  aaaatgaaa  atgtattta  ttcatttgt  tttatcatg  gatgccccc  30840
actgtactg  aagtgaaga  caaggtgcc  gacagtaag  acacaaatt  tctaaagca  30900
caagtgtta  aaattctta  tggtgtgaa  atattagga  gttagtttt  tcttctcat  30960
gccatttta  caactgaca  gggcatcac  aagtagtga  aggcgggcg  ggtggctca  31020
atctgtaat  ccagcactt  gggaggcca  ggagggtgg  tcacctgat  tcaggagtt  31080
gagaccacc  tggccaatg  gatgaaacc  catttctac  aaatatgca  aaattagcc  31140
ggagtggtg  tgcatccca  taatcccag  tgaggtgga  gaactgctt  agcccggga  31200
gcagaggct  cagtgagcc  agatcgcgc  actgcactc  agcctgggt  acagaaaca  31260
agaccctgt  tcaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaagtag  31320
gaaagtccc  gaaaggcat  aggatggag  atgtaaaag  ttggataag  taaaaaaat  31380
agttcgttt  ctaaaataa  tttcttcag  aattgaaat  catacttca  ctcccacat  31440
tatatcact  tcaagttaa  taaaaaaat  attagattt  tgtgcagtg  tttctttta  31500
atttaatag  taaaatttt  atttttctg  tcactttag  ttttgatag  ggtaaaatg  31560
ggaattaaa  caccaaaga  ttgaaaggc  aaatgccac  atataggaa  taaattgtg  31620
cttctttta  aaagcatgg  tatgtaaga  agttaataa  aacataaaa  atattaaaa  31680
aatcattta  accaaatat  aaaagagat  taaagctcc  tctgatgag  ccagttt  31737



<210> 579
<211> 699
<212> PRT
<213> Homo sapiens
<308> AAC83179
<400> 579

Met Thr Ser Leu Lys Arg Ser Gln Thr Glu Arg Pro Leu Ala Thr Asp 
  1               5                  10                  15
Arg Ala Ser Val Val Gly Thr Asp Gly Thr Pro Lys Val His Thr Asp 
             20                  25                  30
Asp Phe Tyr Met Arg Arg Phe Arg Ser Gln Asn Gly Ser Leu Gly Ser 
         35                  40                  45
Ser Val Met Ala Pro Val Gly Pro Pro Arg Ser Glu Gly Ser His His 
     50                  55                  60
Ile Thr Ser Thr Pro Gly Val Pro Lys Met Gly Val Arg Ala Arg Ile 
 65                  70                  75                  80
Ala Asp Trp Pro Pro Arg Lys Glu Asn Ile Lys Glu Ser Ser Arg Ser 
                 85                  90                  95
Ser Gln Glu Ile Glu Thr Ser Ser Cys Leu Asp Ser Leu Ser Ser Lys 
             100                105                110
Ser Ser Pro Val Ser Gln Gly Ser Ser Val Ser Leu Asn Ser Asn Asp 
         115                120                125
Ser Ala Met Leu Lys Ser Ile Gln Asn Thr Leu Lys Asn Lys Thr Arg 
     130                135                140
Pro Ser Glu Asn Met Asp Ser Arg Phe Leu Met Pro Glu Ala Tyr Pro 
 145                150                155                160
Ser Ser Pro Arg Lys Ala Leu Arg Arg Ile Arg Gln Arg Ser Asn Ser 
                 165                170                175
Asp Ile Thr Ile Ser Glu Leu Asp Val Asp Ser Phe Asp Glu Cys Ile 
             180                185                190
Ser Pro Thr Tyr Lys Thr Gly Pro Ser Leu His Arg Glu Tyr Gly Ser 
         195                200                205
Thr Ser Ser Ile Asp Lys Gln Gly Thr Ser Gly Glu Ser Phe Phe Asp 
     210                215                220
Leu Leu Lys Gly Tyr Lys Asp Asp Lys Ser Asp Arg Gly Pro Thr Pro 
 225                230                235                240
Thr Lys Leu Ser Asp Phe Leu Ile Thr Gly Gly Gly Lys Gly Ser Gly 
                 245                250                255
Phe Ser Leu Asp Val Ile Asp Gly Pro Ile Ser Gln Arg Glu Asn Leu 
             260                265                270
Arg Leu Phe Lys Glu Arg Glu Lys Pro Leu Lys Arg Arg Ser Lys Ser 
         275                280                285
Glu Thr Gly Asp Ser Ser Ile Phe Arg Lys Leu Arg Asn Ala Lys Gly 
     290                295                300
Glu Glu Leu Gly Lys Ser Ser Asp Leu Glu Asp Asn Arg Ser Glu Asp 
 305                310                315                320
Ser Val Arg Pro Trp Thr Cys Pro Lys Cys Phe Ala His Tyr Asp Val 
                 325                330                335
Gln Ser Ile Leu Phe Asp Leu Asn Glu Ala Ile Met Asn Arg His Asn 
             340                345                350
Val Ile Lys Arg Arg Asn Thr Thr Thr Gly Ala Ser Ala Ala Ala Val 
         355                360                365
Ala Ser Leu Val Ser Gly Pro Leu Ser His Ser Ala Ser Phe Ser Ser 
     370                375                380
Pro Met Gly Ser Thr Glu Asp Leu Asn Ser Lys Gly Ser Leu Ser Met 
 385                390                395                400
Asp Gln Gly Asp Asp Lys Ser Asn Glu Leu Val Met Ser Cys Pro Tyr 
                 405                410                415
Phe Arg Asn Glu Ile Gly Gly Glu Gly Glu Arg Lys Ile Ser Leu Ser 
             420                425                430
Lys Ser Asn Ser Gly Ser Phe Ser Gly Cys Glu Ser Ala Ser Phe Glu 
         435                440                445
Ser Thr Leu Ser Ser His Cys Thr Asn Ala Gly Val Ala Val Leu Glu 
     450                455                460
Val Pro Lys Glu Asn Leu Val Leu His Leu Asp Arg Val Lys Arg Tyr 
 465                470                475                480
Ile Val Glu His Val Asp Leu Gly Ala Tyr Tyr Tyr Arg Lys Phe Phe 
                 485                490                495
Tyr Gln Lys Glu His Trp Asn Tyr Phe Gly Ala Asp Glu Asn Leu Gly 
             500                505                510
Pro Val Ala Val Ser Ile Arg Arg Glu Lys Pro Asp Glu Met Lys Glu 
         515                520                525
Asn Gly Ser Pro Tyr Asn Tyr Arg Ile Ile Phe Arg Thr Ser Glu Leu 
     530                535                540
Met Thr Leu Arg Gly Ser Val Leu Glu Asp Ala Ile Pro Ser Thr Ala 
 545                550                555                560
Lys His Ser Thr Ala Arg Gly Leu Pro Leu Lys Glu Val Leu Glu His 
                 565                570                575
Val Val Pro Glu Leu Asn Val Gln Cys Leu Arg Leu Ala Phe Asn Thr 
             580                585                590
Pro Lys Val Thr Glu Gln Leu Met Lys Leu Asp Glu Gln Gly Leu Asn 
         595                600                605
Tyr Gln Gln Lys Val Gly Ile Met Tyr Cys Lys Ala Gly Gln Ser Thr 
     610                615                620
Glu Glu Glu Met Tyr Asn Asn Glu Ser Ala Gly Pro Ala Phe Glu Glu 
 625                630                635                640
Phe Leu Gln Leu Leu Gly Glu Arg Val Arg Leu Lys Gly Phe Glu Lys 
                 645                650                655
Tyr Arg Ala Gln Leu Asp Thr Lys Thr Asp Ser Thr Gly Thr His Ser 
             660                665                670
Leu Tyr Thr Thr Tyr Lys Asp Tyr Glu Ile Met Phe His Val Ser Thr 
         675                680                685
Met Leu Pro Tyr Thr Pro Asn Asn Lys Gln Gln 
     690                695



<210> 580
<211> 6331
<212> DNA
<213> Rattus norvegicus
<308> AF026505
<400> 580

gaattcggc  cgaggaaaa  tctttggag  gaagagagc  acagtgagc  cgctagtgc  60
caattattg  agccacgtg  gcccgcaag  tggccctgc  acaagctgt  gagtgctgt  120
gcaattagc  gattggaga  cggggactg  agggtgata  tgctgcgtc  ccgctcgcg  180
gcaccagga  agggttttg  ctcgggaag  caagtcttc  ctgcacagt  atctcagca  240
ctccctagc  gaagagaac  gggggctct  aagggaggg  gtcgcactg  gcgagcaca  300
attctgtgc  aggctgttg  ttatgaacc  cacgtctgg  aaagcaggt  tgtgctcgg  360
cgggcactg  gctggaacg  aggcggcgg  tctcgggtt  acctgcttc  tgttaacag  420
ctgttggct  acagagcat  tgctcttac  cgctgaaac  gcggctgag  aagggttcc  480
ggcatccca  ttgactgac  gaggcactt  gattggact  aatcttaaa  ctctggagg  540
caagacctt  taaaaaggg  taaataaac  atctacatg  taaaggcca  cgactccta  600
ttcctctgt  ggagcaact  tgaagtcca  cctcttcta  gaaaactga  gactttaat  660
acacaccgt  caaggtgaa  atgaataca  atagcggtg  gtgtgctcg  aaacgtgcc  720
ccatgtctg  cacgttaac  tctgtgaag  gagttcaaa  ttctccaaa  ctattggct  780
cagggcgtg  gtctcactc  ccggactca  cttggagat  ttacaatgg  cgaaatcca  840
agacactga  cggagatgc  acatattcc  ctcttgcag  aaaaggttt  agaagcgtt  900
gaccaaacc  gcaagacaa  aagtcacca  cccagagcc  tatcactat  aacggcaac  960
ctggtggcg  cgtgagtcc  gtgagttac  atcagaggc  attctcccc  tctgcatac  1020
ccctcccag  ctcactcaa  tccagcatt  tcatgccac  cggcaggtc  cttgattct  1080
cggagacat  ttcccagca  gcccagtcg  tagacggca  catgggaag  tccatccca  1140
tctacagat  ctccgagga  gagaagagg  tcacagtca  caaagcccc  cattaccca  1200
ggatcggcc  tgtggatga  tctggaatc  ccacagcca  tagaacgac  gttgaccgg  1260
cgaaggact  gtacaagac  atgtttaaa  aaattcaca  ggtacacaa  ccggatgag  1320
acacagaca  gtataatac  ccttacaca  acaatgcag  tctgtacaa  tcgccctac  1380
gtgctcagt  acatcctgc  gcaaagacc  agacctaca  acctctttc  aaaagccac  1440
cggacaatg  caccgatgc  tttaaggag  caccctcac  agtgcctcc  ccacacgtt  1500
caccacgac  aagagatca  tcttcaaca  aaaagcatg  ctgggatcc  ccagacaga  1560
aggtggaca  caggaaatt  cgatcggag  caaggagta  ttttgaata  gagcctggg  1620
agtcatcca  cctgcagca  gaaagaccc  tctccgtct  ccagtcttc  atagacaga  1680
gcttggaaa  acccagcag  tctgcaagc  tggcgggtg  ctttagaaa  cggaggaag  1740
gtgaacctg  agtgggccc  cccaggggc  tgggggatc  cagttcaag  aggaccagc  1800
ccggccggg  agacctccc  ggatcaagt  ccaccttta  cacgtcttt  attagttct  1860
ctccttcct  tccctcgag  gcacaaggt  gggatgata  caaaatgtg  ccgcccctt  1920
gcagttact  ggggctcaa  ggctcgccc  ctagtgagt  agagtgctg  ggcgcttat  1980
gaaggcact  ggacgtccc  caggactct  aaagggcca  cactttcaa  aacggctgg  2040
aaatggccc  gcaaaatgc  gagatctgg  gtagcactg  agaggcggt  tcccccaaa  2100
tcaaatcac  aagctgtga  gatctcctg  atgatgact  cggcagctt  ccagaccct  2160
aaaccaagt  agaaagcat  ggttctctg  tatgtgacg  aggctccaa  gagagcgac  2220
ccatgacgt  gacttcccc  tacatcccg  aagtgtgcg  gaacagcag  tctaggctc  2280
aacataggt  agcccataa  gccccaggc  tcctcaaaa  gtacaagaa  atgcaccgc  2340
tcaaccgca  ggatttgat  aactcggag  tcatttgct  tgtgaaatc  aggatcctt  2400
agtacgaga  ggaacagca  cacaggggg  tgctccatg  atggagcca  tcgtccacc  2460
aggaggtgc  cagggacgt  gtacccact  gcatctcgg  gtttgagaa  ctgattcag  2520
agtcaaagt  tatgcccaa  ctaggagat  aaatgttat  tcctgtaac  ctagaaccc  2580
cacaaaatg  tttgtgccc  aagaggcga  tttctattg  gtctctgct  gaggaggaa  2640
ctcaggtcc  acacccttc  cagggtcag  gaagctgca  gtcgaacac  ctggtaccc  2700
tccacatcg  ggtcaccag  gatgagcaa  ctagaacac  tatggagtt  tccgacagt  2760
accaagatg  ggttgtgtc  gaccacagc  ataacgtcc  cgtcgaaag  tcgtccttt  2820
gtagtgaaa  tgacttcga  cacttttca  tcacatcct  tgaaagttt  tacggatcc  2880
gccatcacc  ccaccatca  caccaccat  acggacact  catcagttc  tgcaaaggc  2940
gatgccccg  ttcttacac  cgatttacc  cgatgttaa  acacgaaag  gctaagcat  3000
aaaatattg  ccgacccag  aggcaagac  tggatcctg  cctatctaa  ctcgcgttt  3060
tagtcagcc  tgtgccttt  cgaaggaaa  aagttttga  tccccaaaa  caaactgag  3120
aggcaaaat  caaagcctc  gtagttgag  ctctggact  tgcccttaa  gacatttgc  3180
accaaataa  agctgaaaa  cggagagga  gcttgccgg  caacagcat  ctgcacagg  3240
ttattagtg  actgctgcc  cagattcct  agaggaatt  atctcttaa  gctctaaaa  3300
ggagcccca  gcaccagcc  ttccaccca  tgcctcaag  tggtgctat  cattgtccc  3360
tgtaccaaa  tgattgtgg  agaatgcct  acagtgcct  tttcccaga  gtggacacg  3420
ccagcagct  ccacgcaca  gactatggt  gtgtgctga  tctccaaga  cacgagtcc  3480
ctagaagtt  ctcgtctac  ctgactgac  tgggaagaa  tgtatcacg  gaacgaaga  3540
gaactccag  aaaagaggt  aaattgcct  caaaagctg  ctatgattt  aaagctcag  3600
cttctaagg  gctgtcatt  aagaaagga  acaccgtct  catcctcag  aaaattgac  3660
agaactggt  tgaggggga  caccacgga  gagtgggca  tttcccaat  tcatacgta  3720
agaaactaa  acccccaga  aaagcgcag  ccgcgagac  accaccccc  gtccagccg  3780
gagagattg  agaagccat  gccaagtac  acttcaatg  agacacaaa  gtggaactc  3840
ccctgagaa  gggtgacag  attattctt  tcaaaagag  tgatcaaaa  tggtatgaa  3900
gtaaaatcc  aggaaccaa  agacaaggc  tcttccctg  ctcctacgt  gaagttgtc  3960
agaggaaca  gaaaggttc  gaggattac  ccgaccctc  tctacccca  agctactcc  4020
gtgatagaa  ttacagcct  agctccaat  agccacagc  tcctgtgtt  tctcacgaa  4080
acattcaag  tggaggaga  ccgtttcag  ctctgtata  ctatactcc  aggaatgaa  4140
atgagctgg  actcagaga  agtgatgtc  tagatgtca  ggaaaagtg  gatgacgga  4200
ggttcgtgg  aacttcaag  agaaccaaa  tctttggta  ttttcctgg  aactatgtc  4260
aaaggctgt  actcacctc  ctcctaatt  atgccacat  tcagccaca  atctgcatt  4320
acccacctg  aacgtccca  gaggcctgt  gctgcctcg  cttatggtt  cccaatagc  4380
cattaccat  tccatctgc  gccaccaaa  caccagcag  gggactgcc  ctgtgagcc  4440
tagggaggc  gggagcctt  gagaaaagt  gcaaaactt  cacccacat  aatattcag  4500
ctcctgctt  ctgccctga  ctttgaaat  cctgtatat  gaatcagaa  gaaaatgat  4560
atactttca  aaaagtgaa  taattaagg  agaaagaaa  agaaaagaa  tagagagac  4620
cttcaggag  ctgtctggc  tcatggctg  atctccacc  ctctggaag  tgtactgtc  4680
tcaggaagc  tgaagattg  tttttttct  aaatgctat  gttccagtt  tcactctca  4740
ctaggcggt  tattttcct  tcacgagtt  gcctagcgc  cgggtttac  ctacatgac  4800
actatactt  ggctgttgt  tgcttgcac  tattattcc  tgtttcatg  acagtgatc  4860
caaaatcca  agtgcctag  gaaggttca  tggttccac  ggttcgagt  tgatttttg  4920
tgactgcat  atattttca  acggggagg  gggtctttc  cctgcccac  tttttgtgc  4980
tattagaag  gcaaacagt  agcaactga  agctcagcc  caccacagg  caaatccgt  5040
ttgtgaatt  gcattgctg  tttgtgtat  aaggtgtaa  catcagctt  atggacaac  5100
agctattag  gatttcttt  cctgttaaa  cttacaggc  gtgctagtg  gttaggcag  5160
aagntgaca  taataccag  aggtgagct  cactgcgtg  atgctcaca  gtttgagnt  5220
gtatgagga  atataattc  tatgctatg  tgtacattt  atggaaata  aagagaatc  5280
cacattatt  tatagagta  ttcaggagc  tcctaagtg  taaggctgg  tttagcaag  5340
attatgatc  atacaacta  ttttactac  ataattatt  ttcttctat  agacccaga  5400
tcctgactc  acttgcaga  aggaatata  atgttgagc  tgacttttt  ttctggtat  5460
tgtaaaata  ttcccagga  tacattggg  acttttggg  ataatggtt  aatcattca  5520
gttgtgctt  ctgccccca  aacagatct  caaaatgat  ccaaacctg  aagatttaa  5580
ggatttacg  tgcctgcat  ccacacaac  tcacactta  ctttgtatt  caaatgaat  5640
tgcataaaa  ctgttcact  tancacctt  tagtcaaaa  tttttatgg  tttcctccc  5700
tgggcaatg  ttgatcttc  caacatata  actctggca  attttgttc  tatgtttgt  5760
cctttttgg  tgtacagac  atttacttg  tcagaaaac  tcgagatct  ccaatttgt  5820
ctttacccc  cccttaaaa  gaatttaaa  tctttcaga  gatcgccct  caccacatc  5880
ccacagatc  caagctaag  tgaatctgg  atatancgt  tgcacaaaa  tttgtgact  5940
agaaaganc  ttgtaacta  nctgaaata  atataataa  aatgttcca  ttacagagg  6000
atattgttg  ggcaggaag  gaagaaaca  cttcaagaa  cccacttta  nctccagtt  6060
acaactagc  ttatattag  aaaacttgg  attggaaag  cagccagcc  gccggccac  6120
tgcagcntt  ttgataaat  aatactttt  cacaccatt  atgaaaaca  ancttcaac  6180
ctgttgcct  ttatattta  gaaaaattg  tgtttctac  cnctgtatc  gattttaaa  6240
ggaaaaaaa  attcacgcc  ggctttcag  acattgact  tgaatnctt  cgagcaaag  6300
ncgttgtgt  tttcttgcn  gtgccgaat  c  6331



<210> 581
<211> 1196
<212> PRT
<213> Rattus norvegicus
<308> AAB81527
<400> 581

Met Asn Thr Asp Ser Gly Gly Cys Ala Arg Lys Arg Ala Ala Met Ser 
  1               5                  10                  15
Val Thr Leu Thr Ser Val Lys Arg Val Gln Ser Ser Pro Asn Leu Leu 
             20                  25                  30
Ala Ala Gly Arg Glu Ser His Ser Pro Asp Ser Ala Trp Arg Ser Tyr 
         35                  40                  45
Asn Gly Arg Asn Pro Glu Thr Leu Asn Gly Asp Ala Thr Tyr Ser Ser 
     50                  55                  60
Leu Ala Ala Lys Gly Phe Arg Ser Val Arg Pro Asn Leu Gln Asp Lys 
 65                  70                  75                  80
Lys Ser Pro Thr Gln Ser His Ile Thr Ile Asn Gly Asn Ser Gly Gly 
                 85                  90                  95
Ala Val Ser Pro Val Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala 
             100                105                110
Tyr Ser Leu Pro Ala Ser Leu Asn Ser Ser Ile Ile Met Pro His Gly 
         115                120                125
Arg Ser Leu Asp Ser Ala Glu Thr Tyr Ser Gln His Ala Gln Ser Leu 
     130                135                140
Asp Gly Thr Met Gly Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu 
 145                150                155                160
Glu Lys Arg Val Thr Val Ile Lys Ala Pro His Tyr Pro Gly Ile Gly 
                 165                170                175
Pro Val Asp Glu Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr Val Asp 
             180                185                190
Arg Pro Lys Asp Trp Tyr Lys Thr Met Phe Lys Gln Ile His Met Val 
         195                200                205
His Lys Pro Asp Glu Asp Thr Asp Met Tyr Asn Thr Pro Tyr Thr Tyr 
     210                215                220
Asn Ala Gly Leu Tyr Asn Ser Pro Tyr Ser Ala Gln Ser His Pro Ala 
 225                230                235                240
Ala Lys Thr Gln Thr Tyr Arg Pro Leu Ser Lys Ser His Ser Asp Asn 
                 245                250                255
Gly Thr Asp Ala Phe Lys Glu Ala Pro Ser Pro Val Pro Pro Pro His 
             260                265                270
Val Pro Pro Arg Pro Arg Asp Gln Ser Ser Thr Glu Lys His Asp Trp 
         275                280                285
Asp Pro Pro Asp Arg Lys Val Asp Thr Arg Lys Phe Arg Ser Glu Pro 
     290                295                300
Arg Ser Ile Phe Glu Tyr Glu Pro Gly Lys Ser Ser Ile Leu Gln His 
 305                310                315                320
Glu Arg Pro Val Ser Val Tyr Gln Ser Ser Ile Asp Arg Ser Leu Glu 
                 325                330                335
Arg Pro Ser Ser Ser Ala Ser Met Ala Gly Asp Phe Arg Lys Arg Arg 
             340                345                350
Lys Ser Glu Pro Ala Val Gly Pro Pro Arg Gly Leu Gly Asp His Ser 
         355                360                365
Ser Ser Arg Thr Ser Pro Gly Arg Ala Asp Leu Pro Gly Ser Ser Ser 
     370                375                380
Thr Phe Thr Thr Ser Phe Ile Ser Ser Ser Pro Ser Ser Pro Ser Arg 
 385                390                395                400
Ala Gln Gly Gly Asp Asp Ser Lys Met Cys Pro Pro Leu Cys Ser Tyr 
                 405                410                415
Ser Gly Leu Asn Gly Ser Pro Ser Ser Glu Leu Glu Cys Cys Gly Ala 
             420                425                430
Tyr Arg Arg His Leu Asp Val Pro Gln Asp Ser Gln Arg Ala Ile Thr 
         435                440                445
Phe Lys Asn Gly Trp Gln Met Ala Arg Gln Asn Ala Glu Ile Trp Ser 
     450                455                460
Ser Thr Glu Glu Ala Val Ser Pro Lys Ile Lys Ser Arg Ser Cys Asp 
 465                470                475                480
Asp Leu Leu Asn Asp Asp Cys Gly Ser Phe Pro Asp Pro Lys Thr Lys 
                 485                490                495
Ser Glu Ser Met Gly Ser Leu Leu Cys Asp Glu Gly Ser Lys Glu Ser 
             500                505                510
Asp Pro Met Thr Trp Thr Ser Pro Tyr Ile Pro Glu Val Cys Gly Asn 
         515                520                525
Ser Arg Ser Arg Leu Lys His Arg Ser Ala His Asn Ala Pro Gly Phe 
     530                535                540
Leu Lys Met Tyr Lys Lys Met His Arg Ile Asn Arg Lys Asp Leu Met 
 545                550                555                560
Asn Ser Glu Val Ile Cys Ser Val Lys Ser Arg Ile Leu Gln Tyr Glu 
                 565                570                575
Lys Glu Gln Gln His Arg Gly Leu Leu His Gly Trp Ser Gln Ser Ser 
             580                585                590
Thr Glu Glu Val Pro Arg Asp Val Val Pro Thr Arg Ile Ser Glu Phe 
         595                600                605
Glu Lys Leu Ile Gln Lys Ser Lys Ser Met Pro Asn Leu Gly Asp Glu 
     610                615                620
Met Leu Ser Pro Val Thr Leu Glu Pro Pro Gln Asn Gly Leu Cys Pro 
 625                630                635                640
Lys Arg Arg Phe Ser Ile Glu Ser Leu Leu Glu Glu Glu Thr Gln Val 
                 645                650                655
Arg His Pro Ser Gln Gly Gln Arg Ser Cys Lys Ser Asn Thr Leu Val 
             660                665                670
Pro Ile His Ile Glu Val Thr Ser Asp Glu Gln Pro Arg Thr His Met 
         675                680                685
Glu Phe Ser Asp Ser Asp Gln Asp Gly Val Val Ser Asp His Ser Asp 
     690                695                700
Asn Val His Val Glu Arg Ser Ser Phe Cys Ser Glu Ser Asp Phe Asp 
 705                710                715                720
His Phe Ser Phe Thr Ser Ser Glu Ser Phe Tyr Gly Ser Ser His His 
                 725                730                735
His His His His His His His His Gly His Phe Ile Ser Ser Cys Lys 
             740                745                750
Gly Arg Cys Pro Ala Ser Tyr Thr Arg Phe Thr Thr Met Leu Lys His 
         755                760                765
Glu Arg Ala Lys His Glu Asn Ile Asp Arg Pro Arg Arg Gln Asp Met 
     770                775                780
Asp Pro Gly Leu Ser Lys Leu Ala Phe Leu Val Ser Pro Val Pro Phe 
 785                790                795                800
Arg Arg Lys Lys Val Leu Thr Pro Gln Lys Gln Thr Glu Gln Ala Lys 
                 805                810                815
Cys Lys Ala Ser Val Val Glu Ala Leu Asp Ser Ala Leu Lys Asp Ile 
             820                825                830
Cys Asp Gln Ile Lys Ala Glu Lys Arg Arg Gly Ser Leu Pro Asp Asn 
         835                840                845
Ser Ile Leu His Arg Leu Ile Ser Glu Leu Leu Pro Gln Ile Pro Lys 
     850                855                860
Arg Asn Ser Ser Leu Asn Ala Leu Lys Arg Ser Pro Met His Gln Pro 
 865                870                875                880
Phe His Pro Leu Pro Gln Asp Gly Ala Ile His Cys Pro Leu Tyr Gln 
                 885                890                895
Asn Asp Cys Gly Arg Met Pro His Ser Ala Ser Phe Pro Asp Val Asp 
             900                905                910
Thr Thr Ser Ser Tyr His Ala Gln Asp Tyr Gly Ser Val Leu Ser Leu 
         915                920                925
Gln Asp His Glu Ser Pro Arg Ser Tyr Ser Ser Thr Leu Thr Asp Leu 
     930                935                940
Gly Arg Ser Val Ser Arg Glu Arg Arg Gly Thr Pro Glu Lys Glu Val 
 945                950                955                960
Lys Leu Pro Ala Lys Ala Val Tyr Asp Phe Lys Ala Gln Thr Ser Lys 
                 965                970                975
Glu Leu Ser Phe Lys Lys Gly Asp Thr Val Tyr Ile Leu Arg Lys Ile 
             980                985                990
Asp Gln Asn Trp Tyr Glu Gly Glu His His Gly Arg Val Gly Ile Phe 
         995                1000                1005
Pro Ile Ser Tyr Val Glu Lys Leu Thr Pro Pro Glu Lys Ala Gln Pro 
     1010                1015                1020
Ala Arg Pro Pro Pro Pro Val Gln Pro Gly Glu Ile Gly Glu Ala Ile 
 1025                1030                1035                1040
Ala Lys Tyr Asn Phe Asn Ala Asp Thr Asn Val Glu Leu Ser Leu Arg 
                 1045                1050                1055
Lys Gly Asp Arg Ile Ile Leu Leu Lys Arg Val Asp Gln Asn Trp Tyr 
             1060                1065                1070
Glu Gly Lys Ile Pro Gly Thr Asn Arg Gln Gly Ile Phe Pro Val Ser 
         1075                1080                1085
Tyr Val Glu Val Val Lys Arg Asn Thr Lys Gly Ser Glu Asp Tyr Pro 
     1090                1095                1100
Asp Pro Pro Leu Pro His Ser Tyr Ser Ser Asp Arg Ile Tyr Ser Leu 
 1105                1110                1115                1120
Ser Ser Asn Lys Pro Gln Arg Pro Val Phe Ser His Glu Asn Ile Gln 
                 1125                1130                1135
Gly Gly Gly Glu Pro Phe Gln Ala Leu Tyr Asn Tyr Thr Pro Arg Asn 
             1140                1145                1150
Glu Asp Glu Leu Glu Leu Arg Glu Ser Asp Val Val Asp Val Met Glu 
         1155                1160                1165
Lys Cys Asp Asp Gly Trp Phe Val Gly Thr Ser Arg Arg Thr Lys Phe 
     1170                1175                1180
Phe Gly Thr Phe Pro Gly Asn Tyr Val Lys Arg Leu 
 1185                1190                1195



<210> 582
<211> 1569
<212> DNA
<213> Homo sapiens
<308> AF396457
<400> 582

atgaaagca  caacacctt  gcagacagt  gaccggccc  aggactggt  caagacgat  60
tttaagcaa  ttcacatgg  gcacaagcc  gatgatgac  cagacatgt  taatactcc  120
acacctcac  tgaaatata  atacaatgc  ggtctgtac  acccaccct  cagtgctca  180
tcacaccct  ctgcaaaga  ccaaaccta  agacctctt  ccaaaagcc  ctccgacaa  240
agccccaat  cctttaagg  tgcgtcctc  ccagtgcct  ccccacatg  tccacctcc  300
gtcccgccg  ttcgaccaa  agatcggtc  tcaacagaa  agcatgact  ggatcctcc  360
gacagaaaa  tggacacaa  aaatttcgg  tctgagcca  ggagtattt  tgaatacga  420
gacagaaaa  tggacacga  aaaatttcg  tcggagcca  ggtctattt  tgaatacga  480
cctgggaag  catccatcc  gcagcacga  cgacccgtc  accagtctt  catagacag  540
agcttggaa  gacccagca  ctctgcaag  atggcgggt  actttagaa  acggaggaa  600
agtgaacct  cagtgggcc  gcccagggg  ttgggggat  acagttcaa  caggaccag  660
cccggccgg  cagacctcc  aggatcaag  tccaccttt  ccacgtctt  cattagttc  720
tctccttcc  ctccctcga  agcacaagg  ggggatgat  gcaaaatgt  tccgcccct  780
tgcagttac  cggggctca  tggctcgcc  tctagtgag  tagagtgct  cggcgctta  840
agaaggcac  tggacgtcc  ccaggactc  caaagggcc  tcactttca  gaacggctg  900
caaatggcc  ggcaaaatg  agagatctg  agtagcact  aagaggcgg  ttcccccaa  960
atcaaatca  gaagctgtg  cgatctcct  aatgatgac  gcggcagct  cccagaccc  1020
aaaaccaag  cagaaagca  gggttctct  ttatgtgac  aaggctcca  agagagcga  1080
cccatgacg  ggacttccc  ctacatccc  gaagtgtgc  ggaacagca  agaattcat  1140
ttaagcaaa  ggatattcg  ggaatctct  gatggagga  cattttgga  agtgctaaa  1200
gaatatcta  agcgagtga  gaatctatg  gaaagatgt  aagtgcaag  cgtaaattt  1260
ttggttgag  agatgatca  tgatttaaa  gtataacag  gtagatgcc  cccccctca  1320
aaacgcata  cccccccct  accctgaca  ttagctttg  atatgcaca  aatagtttg  1380
ggggagaat  gaaccctat  tctgaaagt  tatgtgttg  gatttcatc  catatatgg  1440
ggtagccgc  aactcagag  taggtcgtt  tgtaagatt  tcacaacaa  atgtataac  1500
caaacattc  tgagtcaaa  tgtacaaca  aaggtcacg  aaccgcaag  agggcgccg  1560
gataagtcc  1569



<210> 583
<211> 1100
<212> PRT
<213> Homo sapiens
<308> NP_066547
<400> 583

Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr Ser Leu Pro 
  1               5                  10                  15
Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly Thr Ser Leu Asp 
             20                  25                  30
Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp Gly Thr Thr 
         35                  40                  45
Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu Glu Lys Arg Val 
     50                  55                  60
Thr Val Ile Lys Ala Pro His Tyr Pro Gly Ile Gly Pro Val Asp Glu 
 65                  70                  75                  80
Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr Val Asp Arg Pro Lys Asp 
                 85                  90                  95
Trp Tyr Lys Thr Met Phe Lys Gln Ile His Met Val His Lys Pro Asp 
             100                105                110
Asp Asp Thr Asp Met Tyr Asn Thr Pro Tyr Thr Tyr Asn Ala Gly Leu 
         115                120                125
Tyr Asn Pro Pro Tyr Ser Ala Gln Ser His Pro Ala Ala Lys Thr Gln 
     130                135                140
Thr Tyr Arg Pro Leu Ser Lys Ser His Ser Asp Asn Ser Pro Asn Ala 
 145                150                155                160
Phe Lys Asp Ala Ser Ser Pro Val Pro Pro Pro His Val Pro Pro Pro 
                 165                170                175
Val Pro Pro Leu Arg Pro Arg Asp Arg Ser Ser Thr Glu Lys His Asp 
             180                185                190
Trp Asp Pro Pro Asp Arg Lys Val Asp Thr Arg Lys Phe Arg Ser Glu 
         195                200                205
Pro Arg Ser Ile Phe Glu Tyr Glu Pro Gly Lys Ser Ser Ile Leu Gln 
     210                215                220
His Glu Arg Pro Ala Ser Leu Tyr Gln Ser Ser Ile Asp Arg Ser Leu 
 225                230                235                240
Glu Arg Pro Met Ser Ser Ala Ser Met Ala Ser Asp Phe Arg Lys Arg 
                 245                250                255
Arg Lys Ser Glu Pro Ala Val Gly Pro Pro Arg Gly Leu Gly Asp Gln 
             260                265                270
Ser Ala Ser Arg Thr Ser Pro Gly Arg Val Asp Leu Pro Gly Ser Ser 
         275                280                285
Thr Thr Leu Thr Lys Ser Phe Thr Ser Ser Ser Pro Ser Ser Pro Ser 
     290                295                300
Arg Ala Lys Gly Gly Asp Asp Ser Lys Ile Cys Pro Ser Leu Cys Ser 
 305                310                315                320
Tyr Ser Gly Leu Asn Gly Asn Pro Ser Ser Glu Leu Asp Tyr Cys Ser 
                 325                330                335
Thr Tyr Arg Gln His Leu Asp Val Pro Arg Asp Ser Pro Arg Ala Ile 
             340                345                350
Ser Phe Lys Asn Gly Trp Gln Met Ala Arg Gln Asn Ala Glu Ile Trp 
         355                360                365
Ser Ser Thr Glu Glu Thr Val Ser Pro Lys Ile Lys Ser Arg Ser Cys 
     370                375                380
Asp Asp Leu Leu Asn Asp Asp Cys Asp Ser Phe Pro Asp Pro Lys Val 
 385                390                395                400
Lys Ser Glu Ser Met Gly Ser Leu Leu Cys Glu Glu Asp Ser Lys Glu 
                 405                410                415
Ser Cys Pro Met Ala Trp Gly Ser Pro Tyr Val Pro Glu Val Arg Ser 
             420                425                430
Asn Gly Arg Ser Arg Ile Arg His Arg Ser Ala Arg Asn Ala Pro Gly 
         435                440                445
Phe Leu Lys Met Tyr Lys Lys Met His Arg Ile Asn Arg Lys Asp Leu 
     450                455                460
Met Asn Ser Glu Val Ile Cys Ser Val Lys Ser Arg Ile Leu Gln Tyr 
 465                470                475                480
Glu Ser Glu Gln Gln His Lys Asp Leu Leu Arg Ala Trp Ser Gln Cys 
                 485                490                495
Ser Thr Glu Glu Val Pro Arg Asp Met Val Pro Thr Arg Ile Ser Glu 
             500                505                510
Phe Glu Lys Leu Ile Gln Lys Ser Lys Ser Met Pro Asn Leu Gly Asp 
         515                520                525
Asp Met Leu Ser Pro Val Thr Leu Glu Pro Pro Gln Asn Gly Leu Cys 
     530                535                540
Pro Lys Arg Arg Phe Ser Ile Glu Tyr Leu Leu Glu Glu Glu Asn Gln 
 545                550                555                560
Ser Gly Pro Pro Ala Arg Gly Arg Arg Gly Cys Gln Ser Asn Ala Leu 
                 565                570                575
Val Pro Ile His Ile Glu Val Thr Ser Asp Glu Gln Pro Arg Ala His 
             580                585                590
Val Glu Phe Ser Asp Ser Asp Gln Asp Gly Val Val Ser Asp His Ser 
         595                600                605
Asp Tyr Ile His Leu Glu Gly Ser Ser Phe Cys Ser Glu Ser Asp Phe 
     610                615                620
Asp His Phe Ser Phe Thr Ser Ser Glu Ser Phe Tyr Gly Ser Ser His 
 625                630                635                640
His His His His His His His His His His Arg His Leu Ile Ser Ser 
                 645                650                655
Cys Lys Gly Arg Cys Pro Ala Ser Tyr Thr Arg Phe Thr Thr Met Leu 
             660                665                670
Lys His Glu Arg Ala Arg His Glu Asn Thr Glu Glu Pro Arg Arg Gln 
         675                680                685
Glu Met Asp Pro Gly Leu Ser Lys Leu Ala Phe Leu Val Ser Pro Val 
     690                695                700
Pro Phe Arg Arg Lys Lys Asn Ser Ala Pro Lys Lys Gln Thr Glu Lys 
 705                710                715                720
Ala Lys Cys Lys Ala Ser Val Phe Glu Ala Leu Asp Ser Ala Leu Lys 
                 725                730                735
Asp Ile Cys Asp Gln Ile Lys Ala Glu Lys Lys Arg Gly Ser Leu Pro 
             740                745                750
Asp Asn Ser Ile Leu His Arg Leu Ile Ser Glu Leu Leu Pro Asp Val 
         755                760                765
Pro Glu Arg Asn Ser Ser Leu Arg Ala Leu Arg Arg Ser Pro Leu His 
     770                775                780
Gln Pro Leu His Pro Leu Pro Pro Asp Gly Ala Ile His Cys Pro Pro 
 785                790                795                800
Tyr Gln Asn Asp Cys Gly Arg Met Pro Arg Ser Ala Ser Phe Gln Asp 
                 805                810                815
Val Asp Thr Ala Asn Ser Ser Cys His His Gln Asp Arg Gly Gly Ala 
             820                825                830
Leu Gln Asp Arg Glu Ser Pro Arg Ser Tyr Ser Ser Thr Leu Thr Asp 
         835                840                845
Met Gly Arg Ser Ala Pro Arg Glu Arg Arg Gly Thr Pro Glu Lys Glu 
     850                855                860
Lys Leu Pro Ala Lys Ala Val Tyr Asp Phe Lys Ala Gln Thr Ser Lys 
 865                870                875                880
Glu Leu Ser Phe Lys Lys Gly Asp Thr Val Tyr Ile Leu Arg Lys Ile 
                 885                890                895
Asp Gln Asn Trp Tyr Glu Gly Glu His His Gly Arg Val Gly Ile Phe 
             900                905                910
Pro Ile Ser Tyr Val Glu Lys Leu Thr Pro Pro Glu Lys Ala Gln Pro 
         915                920                925
Ala Arg Pro Pro Pro Pro Ala Gln Pro Gly Glu Ile Gly Glu Ala Ile 
     930                935                940
Ala Lys Tyr Asn Phe Asn Ala Asp Thr Asn Val Glu Leu Ser Leu Arg 
 945                950                955                960
Lys Gly Asp Arg Val Ile Leu Leu Lys Arg Val Asp Gln Asn Trp Tyr 
                 965                970                975
Glu Gly Lys Ile Pro Gly Thr Asn Arg Gln Gly Ile Phe Pro Val Ser 
             980                985                990
Tyr Val Glu Val Val Lys Lys Asn Thr Lys Gly Ala Glu Asp Tyr Pro 
         995                1000                1005
Asp Pro Pro Ile Pro His Ser Tyr Ser Ser Asp Arg Ile His Ser Leu 
     1010                1015                1020
Ser Ser Asn Lys Pro Gln Arg Pro Val Phe Thr His Glu Asn Ile Gln 
 1025                1030                1035                1040
Gly Gly Gly Glu Pro Phe Gln Ala Leu Tyr Asn Tyr Thr Pro Arg Asn 
                 1045                1050                1055
Glu Asp Glu Leu Glu Leu Arg Glu Ser Asp Val Ile Asp Val Met Glu 
             1060                1065                1070
Lys Cys Asp Asp Gly Trp Phe Val Gly Thr Ser Arg Arg Thr Lys Phe 
         1075                1080                1085
Phe Gly Thr Phe Pro Gly Asn Tyr Val Lys Arg Leu 
     1090                1095                1100



<210> 584
<211> 6331
<212> DNA
<213> Rattus norvegicus
<308> AF026505
<400> 584

gaattcggc  cgaggaaaa  tctttggag  gaagagagc  acagtgagc  cgctagtgc  60
caattattg  agccacgtg  gcccgcaag  tggccctgc  acaagctgt  gagtgctgt  120
gcaattagc  gattggaga  cggggactg  agggtgata  tgctgcgtc  ccgctcgcg  180
gcaccagga  agggttttg  ctcgggaag  caagtcttc  ctgcacagt  atctcagca  240
ctccctagc  gaagagaac  gggggctct  aagggaggg  gtcgcactg  gcgagcaca  300
attctgtgc  aggctgttg  ttatgaacc  cacgtctgg  aaagcaggt  tgtgctcgg  360
cgggcactg  gctggaacg  aggcggcgg  tctcgggtt  acctgcttc  tgttaacag  420
ctgttggct  acagagcat  tgctcttac  cgctgaaac  gcggctgag  aagggttcc  480
ggcatccca  ttgactgac  gaggcactt  gattggact  aatcttaaa  ctctggagg  540
caagacctt  taaaaaggg  taaataaac  atctacatg  taaaggcca  cgactccta  600
ttcctctgt  ggagcaact  tgaagtcca  cctcttcta  gaaaactga  gactttaat  660
acacaccgt  caaggtgaa  atgaataca  atagcggtg  gtgtgctcg  aaacgtgcc  720
ccatgtctg  cacgttaac  tctgtgaag  gagttcaaa  ttctccaaa  ctattggct  780
cagggcgtg  gtctcactc  ccggactca  cttggagat  ttacaatgg  cgaaatcca  840
agacactga  cggagatgc  acatattcc  ctcttgcag  aaaaggttt  agaagcgtt  900
gaccaaacc  gcaagacaa  aagtcacca  cccagagcc  tatcactat  aacggcaac  960
ctggtggcg  cgtgagtcc  gtgagttac  atcagaggc  attctcccc  tctgcatac  1020
ccctcccag  ctcactcaa  tccagcatt  tcatgccac  cggcaggtc  cttgattct  1080
cggagacat  ttcccagca  gcccagtcg  tagacggca  catgggaag  tccatccca  1140
tctacagat  ctccgagga  gagaagagg  tcacagtca  caaagcccc  cattaccca  1200
ggatcggcc  tgtggatga  tctggaatc  ccacagcca  tagaacgac  gttgaccgg  1260
cgaaggact  gtacaagac  atgtttaaa  aaattcaca  ggtacacaa  ccggatgag  1320
acacagaca  gtataatac  ccttacaca  acaatgcag  tctgtacaa  tcgccctac  1380
gtgctcagt  acatcctgc  gcaaagacc  agacctaca  acctctttc  aaaagccac  1440
cggacaatg  caccgatgc  tttaaggag  caccctcac  agtgcctcc  ccacacgtt  1500
caccacgac  aagagatca  tcttcaaca  aaaagcatg  ctgggatcc  ccagacaga  1560
aggtggaca  caggaaatt  cgatcggag  caaggagta  ttttgaata  gagcctggg  1620
agtcatcca  cctgcagca  gaaagaccc  tctccgtct  ccagtcttc  atagacaga  1680
gcttggaaa  acccagcag  tctgcaagc  tggcgggtg  ctttagaaa  cggaggaag  1740
gtgaacctg  agtgggccc  cccaggggc  tgggggatc  cagttcaag  aggaccagc  1800
ccggccggg  agacctccc  ggatcaagt  ccaccttta  cacgtcttt  attagttct  1860
ctccttcct  tccctcgag  gcacaaggt  gggatgata  caaaatgtg  ccgcccctt  1920
gcagttact  ggggctcaa  ggctcgccc  ctagtgagt  agagtgctg  ggcgcttat  1980
gaaggcact  ggacgtccc  caggactct  aaagggcca  cactttcaa  aacggctgg  2040
aaatggccc  gcaaaatgc  gagatctgg  gtagcactg  agaggcggt  tcccccaaa  2100
tcaaatcac  aagctgtga  gatctcctg  atgatgact  cggcagctt  ccagaccct  2160
aaaccaagt  agaaagcat  ggttctctg  tatgtgacg  aggctccaa  gagagcgac  2220
ccatgacgt  gacttcccc  tacatcccg  aagtgtgcg  gaacagcag  tctaggctc  2280
aacataggt  agcccataa  gccccaggc  tcctcaaaa  gtacaagaa  atgcaccgc  2340
tcaaccgca  ggatttgat  aactcggag  tcatttgct  tgtgaaatc  aggatcctt  2400
agtacgaga  ggaacagca  cacaggggg  tgctccatg  atggagcca  tcgtccacc  2460
aggaggtgc  cagggacgt  gtacccact  gcatctcgg  gtttgagaa  ctgattcag  2520
agtcaaagt  tatgcccaa  ctaggagat  aaatgttat  tcctgtaac  ctagaaccc  2580
cacaaaatg  tttgtgccc  aagaggcga  tttctattg  gtctctgct  gaggaggaa  2640
ctcaggtcc  acacccttc  cagggtcag  gaagctgca  gtcgaacac  ctggtaccc  2700
tccacatcg  ggtcaccag  gatgagcaa  ctagaacac  tatggagtt  tccgacagt  2760
accaagatg  ggttgtgtc  gaccacagc  ataacgtcc  cgtcgaaag  tcgtccttt  2820
gtagtgaaa  tgacttcga  cacttttca  tcacatcct  tgaaagttt  tacggatcc  2880
gccatcacc  ccaccatca  caccaccat  acggacact  catcagttc  tgcaaaggc  2940
gatgccccg  ttcttacac  cgatttacc  cgatgttaa  acacgaaag  gctaagcat  3000
aaaatattg  ccgacccag  aggcaagac  tggatcctg  cctatctaa  ctcgcgttt  3060
tagtcagcc  tgtgccttt  cgaaggaaa  aagttttga  tccccaaaa  caaactgag  3120
aggcaaaat  caaagcctc  gtagttgag  ctctggact  tgcccttaa  gacatttgc  3180
accaaataa  agctgaaaa  cggagagga  gcttgccgg  caacagcat  ctgcacagg  3240
ttattagtg  actgctgcc  cagattcct  agaggaatt  atctcttaa  gctctaaaa  3300
ggagcccca  gcaccagcc  ttccaccca  tgcctcaag  tggtgctat  cattgtccc  3360
tgtaccaaa  tgattgtgg  agaatgcct  acagtgcct  tttcccaga  gtggacacg  3420
ccagcagct  ccacgcaca  gactatggt  gtgtgctga  tctccaaga  cacgagtcc  3480
ctagaagtt  ctcgtctac  ctgactgac  tgggaagaa  tgtatcacg  gaacgaaga  3540
gaactccag  aaaagaggt  aaattgcct  caaaagctg  ctatgattt  aaagctcag  3600
cttctaagg  gctgtcatt  aagaaagga  acaccgtct  catcctcag  aaaattgac  3660
agaactggt  tgaggggga  caccacgga  gagtgggca  tttcccaat  tcatacgta  3720
agaaactaa  acccccaga  aaagcgcag  ccgcgagac  accaccccc  gtccagccg  3780
gagagattg  agaagccat  gccaagtac  acttcaatg  agacacaaa  gtggaactc  3840
ccctgagaa  gggtgacag  attattctt  tcaaaagag  tgatcaaaa  tggtatgaa  3900
gtaaaatcc  aggaaccaa  agacaaggc  tcttccctg  ctcctacgt  gaagttgtc  3960
agaggaaca  gaaaggttc  gaggattac  ccgaccctc  tctacccca  agctactcc  4020
gtgatagaa  ttacagcct  agctccaat  agccacagc  tcctgtgtt  tctcacgaa  4080
acattcaag  tggaggaga  ccgtttcag  ctctgtata  ctatactcc  aggaatgaa  4140
atgagctgg  actcagaga  agtgatgtc  tagatgtca  ggaaaagtg  gatgacgga  4200
ggttcgtgg  aacttcaag  agaaccaaa  tctttggta  ttttcctgg  aactatgtc  4260
aaaggctgt  actcacctc  ctcctaatt  atgccacat  tcagccaca  atctgcatt  4320
acccacctg  aacgtccca  gaggcctgt  gctgcctcg  cttatggtt  cccaatagc  4380
cattaccat  tccatctgc  gccaccaaa  caccagcag  gggactgcc  ctgtgagcc  4440
tagggaggc  gggagcctt  gagaaaagt  gcaaaactt  cacccacat  aatattcag  4500
ctcctgctt  ctgccctga  ctttgaaat  cctgtatat  gaatcagaa  gaaaatgat  4560
atactttca  aaaagtgaa  taattaagg  agaaagaaa  agaaaagaa  tagagagac  4620
cttcaggag  ctgtctggc  tcatggctg  atctccacc  ctctggaag  tgtactgtc  4680
tcaggaagc  tgaagattg  tttttttct  aaatgctat  gttccagtt  tcactctca  4740
ctaggcggt  tattttcct  tcacgagtt  gcctagcgc  cgggtttac  ctacatgac  4800
actatactt  ggctgttgt  tgcttgcac  tattattcc  tgtttcatg  acagtgatc  4860
caaaatcca  agtgcctag  gaaggttca  tggttccac  ggttcgagt  tgatttttg  4920
tgactgcat  atattttca  acggggagg  gggtctttc  cctgcccac  tttttgtgc  4980
tattagaag  gcaaacagt  agcaactga  agctcagcc  caccacagg  caaatccgt  5040
ttgtgaatt  gcattgctg  tttgtgtat  aaggtgtaa  catcagctt  atggacaac  5100
agctattag  gatttcttt  cctgttaaa  cttacaggc  gtgctagtg  gttaggcag  5160
aagntgaca  taataccag  aggtgagct  cactgcgtg  atgctcaca  gtttgagnt  5220
gtatgagga  atataattc  tatgctatg  tgtacattt  atggaaata  aagagaatc  5280
cacattatt  tatagagta  ttcaggagc  tcctaagtg  taaggctgg  tttagcaag  5340
attatgatc  atacaacta  ttttactac  ataattatt  ttcttctat  agacccaga  5400
tcctgactc  acttgcaga  aggaatata  atgttgagc  tgacttttt  ttctggtat  5460
tgtaaaata  ttcccagga  tacattggg  acttttggg  ataatggtt  aatcattca  5520
gttgtgctt  ctgccccca  aacagatct  caaaatgat  ccaaacctg  aagatttaa  5580
ggatttacg  tgcctgcat  ccacacaac  tcacactta  ctttgtatt  caaatgaat  5640
tgcataaaa  ctgttcact  tancacctt  tagtcaaaa  tttttatgg  tttcctccc  5700
tgggcaatg  ttgatcttc  caacatata  actctggca  attttgttc  tatgtttgt  5760
cctttttgg  tgtacagac  atttacttg  tcagaaaac  tcgagatct  ccaatttgt  5820
ctttacccc  cccttaaaa  gaatttaaa  tctttcaga  gatcgccct  caccacatc  5880
ccacagatc  caagctaag  tgaatctgg  atatancgt  tgcacaaaa  tttgtgact  5940
agaaaganc  ttgtaacta  nctgaaata  atataataa  aatgttcca  ttacagagg  6000
atattgttg  ggcaggaag  gaagaaaca  cttcaagaa  cccacttta  nctccagtt  6060
acaactagc  ttatattag  aaaacttgg  attggaaag  cagccagcc  gccggccac  6120
tgcagcntt  ttgataaat  aatactttt  cacaccatt  atgaaaaca  ancttcaac  6180
ctgttgcct  ttatattta  gaaaaattg  tgtttctac  cnctgtatc  gattttaaa  6240
ggaaaaaaa  attcacgcc  ggctttcag  acattgact  tgaatnctt  cgagcaaag  6300
ncgttgtgt  tttcttgcn  gtgccgaat  c  6331



<210> 585
<211> 1196
<212> PRT
<213> Rattus norvegicus
<308> AAB81527
<400> 585

Met Asn Thr Asp Ser Gly Gly Cys Ala Arg Lys Arg Ala Ala Met Ser 
  1               5                  10                  15
Val Thr Leu Thr Ser Val Lys Arg Val Gln Ser Ser Pro Asn Leu Leu 
             20                  25                  30
Ala Ala Gly Arg Glu Ser His Ser Pro Asp Ser Ala Trp Arg Ser Tyr 
         35                  40                  45
Asn Gly Arg Asn Pro Glu Thr Leu Asn Gly Asp Ala Thr Tyr Ser Ser 
     50                  55                  60
Leu Ala Ala Lys Gly Phe Arg Ser Val Arg Pro Asn Leu Gln Asp Lys 
 65                  70                  75                  80
Lys Ser Pro Thr Gln Ser His Ile Thr Ile Asn Gly Asn Ser Gly Gly 
                 85                  90                  95
Ala Val Ser Pro Val Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala 
             100                105                110
Tyr Ser Leu Pro Ala Ser Leu Asn Ser Ser Ile Ile Met Pro His Gly 
         115                120                125
Arg Ser Leu Asp Ser Ala Glu Thr Tyr Ser Gln His Ala Gln Ser Leu 
     130                135                140
Asp Gly Thr Met Gly Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu 
 145                150                155                160
Glu Lys Arg Val Thr Val Ile Lys Ala Pro His Tyr Pro Gly Ile Gly 
                 165                170                175
Pro Val Asp Glu Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr Val Asp 
             180                185                190
Arg Pro Lys Asp Trp Tyr Lys Thr Met Phe Lys Gln Ile His Met Val 
         195                200                205
His Lys Pro Asp Glu Asp Thr Asp Met Tyr Asn Thr Pro Tyr Thr Tyr 
     210                215                220
Asn Ala Gly Leu Tyr Asn Ser Pro Tyr Ser Ala Gln Ser His Pro Ala 
 225                230                235                240
Ala Lys Thr Gln Thr Tyr Arg Pro Leu Ser Lys Ser His Ser Asp Asn 
                 245                250                255
Gly Thr Asp Ala Phe Lys Glu Ala Pro Ser Pro Val Pro Pro Pro His 
             260                265                270
Val Pro Pro Arg Pro Arg Asp Gln Ser Ser Thr Glu Lys His Asp Trp 
         275                280                285
Asp Pro Pro Asp Arg Lys Val Asp Thr Arg Lys Phe Arg Ser Glu Pro 
     290                295                300
Arg Ser Ile Phe Glu Tyr Glu Pro Gly Lys Ser Ser Ile Leu Gln His 
 305                310                315                320
Glu Arg Pro Val Ser Val Tyr Gln Ser Ser Ile Asp Arg Ser Leu Glu 
                 325                330                335
Arg Pro Ser Ser Ser Ala Ser Met Ala Gly Asp Phe Arg Lys Arg Arg 
             340                345                350
Lys Ser Glu Pro Ala Val Gly Pro Pro Arg Gly Leu Gly Asp His Ser 
         355                360                365
Ser Ser Arg Thr Ser Pro Gly Arg Ala Asp Leu Pro Gly Ser Ser Ser 
     370                375                380
Thr Phe Thr Thr Ser Phe Ile Ser Ser Ser Pro Ser Ser Pro Ser Arg 
 385                390                395                400
Ala Gln Gly Gly Asp Asp Ser Lys Met Cys Pro Pro Leu Cys Ser Tyr 
                 405                410                415
Ser Gly Leu Asn Gly Ser Pro Ser Ser Glu Leu Glu Cys Cys Gly Ala 
             420                425                430
Tyr Arg Arg His Leu Asp Val Pro Gln Asp Ser Gln Arg Ala Ile Thr 
         435                440                445
Phe Lys Asn Gly Trp Gln Met Ala Arg Gln Asn Ala Glu Ile Trp Ser 
     450                455                460
Ser Thr Glu Glu Ala Val Ser Pro Lys Ile Lys Ser Arg Ser Cys Asp 
 465                470                475                480
Asp Leu Leu Asn Asp Asp Cys Gly Ser Phe Pro Asp Pro Lys Thr Lys 
                 485                490                495
Ser Glu Ser Met Gly Ser Leu Leu Cys Asp Glu Gly Ser Lys Glu Ser 
             500                505                510
Asp Pro Met Thr Trp Thr Ser Pro Tyr Ile Pro Glu Val Cys Gly Asn 
         515                520                525
Ser Arg Ser Arg Leu Lys His Arg Ser Ala His Asn Ala Pro Gly Phe 
     530                535                540
Leu Lys Met Tyr Lys Lys Met His Arg Ile Asn Arg Lys Asp Leu Met 
 545                550                555                560
Asn Ser Glu Val Ile Cys Ser Val Lys Ser Arg Ile Leu Gln Tyr Glu 
                 565                570                575
Lys Glu Gln Gln His Arg Gly Leu Leu His Gly Trp Ser Gln Ser Ser 
             580                585                590
Thr Glu Glu Val Pro Arg Asp Val Val Pro Thr Arg Ile Ser Glu Phe 
         595                600                605
Glu Lys Leu Ile Gln Lys Ser Lys Ser Met Pro Asn Leu Gly Asp Glu 
     610                615                620
Met Leu Ser Pro Val Thr Leu Glu Pro Pro Gln Asn Gly Leu Cys Pro 
 625                630                635                640
Lys Arg Arg Phe Ser Ile Glu Ser Leu Leu Glu Glu Glu Thr Gln Val 
                 645                650                655
Arg His Pro Ser Gln Gly Gln Arg Ser Cys Lys Ser Asn Thr Leu Val 
             660                665                670
Pro Ile His Ile Glu Val Thr Ser Asp Glu Gln Pro Arg Thr His Met 
         675                680                685
Glu Phe Ser Asp Ser Asp Gln Asp Gly Val Val Ser Asp His Ser Asp 
     690                695                700
Asn Val His Val Glu Arg Ser Ser Phe Cys Ser Glu Ser Asp Phe Asp 
 705                710                715                720
His Phe Ser Phe Thr Ser Ser Glu Ser Phe Tyr Gly Ser Ser His His 
                 725                730                735
His His His His His His His His Gly His Phe Ile Ser Ser Cys Lys 
             740                745                750
Gly Arg Cys Pro Ala Ser Tyr Thr Arg Phe Thr Thr Met Leu Lys His 
         755                760                765
Glu Arg Ala Lys His Glu Asn Ile Asp Arg Pro Arg Arg Gln Asp Met 
     770                775                780
Asp Pro Gly Leu Ser Lys Leu Ala Phe Leu Val Ser Pro Val Pro Phe 
 785                790                795                800
Arg Arg Lys Lys Val Leu Thr Pro Gln Lys Gln Thr Glu Gln Ala Lys 
                 805                810                815
Cys Lys Ala Ser Val Val Glu Ala Leu Asp Ser Ala Leu Lys Asp Ile 
             820                825                830
Cys Asp Gln Ile Lys Ala Glu Lys Arg Arg Gly Ser Leu Pro Asp Asn 
         835                840                845
Ser Ile Leu His Arg Leu Ile Ser Glu Leu Leu Pro Gln Ile Pro Lys 
     850                855                860
Arg Asn Ser Ser Leu Asn Ala Leu Lys Arg Ser Pro Met His Gln Pro 
 865                870                875                880
Phe His Pro Leu Pro Gln Asp Gly Ala Ile His Cys Pro Leu Tyr Gln 
                 885                890                895
Asn Asp Cys Gly Arg Met Pro His Ser Ala Ser Phe Pro Asp Val Asp 
             900                905                910
Thr Thr Ser Ser Tyr His Ala Gln Asp Tyr Gly Ser Val Leu Ser Leu 
         915                920                925
Gln Asp His Glu Ser Pro Arg Ser Tyr Ser Ser Thr Leu Thr Asp Leu 
     930                935                940
Gly Arg Ser Val Ser Arg Glu Arg Arg Gly Thr Pro Glu Lys Glu Val 
 945                950                955                960
Lys Leu Pro Ala Lys Ala Val Tyr Asp Phe Lys Ala Gln Thr Ser Lys 
                 965                970                975
Glu Leu Ser Phe Lys Lys Gly Asp Thr Val Tyr Ile Leu Arg Lys Ile 
             980                985                990
Asp Gln Asn Trp Tyr Glu Gly Glu His His Gly Arg Val Gly Ile Phe 
         995                1000                1005
Pro Ile Ser Tyr Val Glu Lys Leu Thr Pro Pro Glu Lys Ala Gln Pro 
     1010                1015                1020
Ala Arg Pro Pro Pro Pro Val Gln Pro Gly Glu Ile Gly Glu Ala Ile 
 1025                1030                1035                1040
Ala Lys Tyr Asn Phe Asn Ala Asp Thr Asn Val Glu Leu Ser Leu Arg 
                 1045                1050                1055
Lys Gly Asp Arg Ile Ile Leu Leu Lys Arg Val Asp Gln Asn Trp Tyr 
             1060                1065                1070
Glu Gly Lys Ile Pro Gly Thr Asn Arg Gln Gly Ile Phe Pro Val Ser 
         1075                1080                1085
Tyr Val Glu Val Val Lys Arg Asn Thr Lys Gly Ser Glu Asp Tyr Pro 
     1090                1095                1100
Asp Pro Pro Leu Pro His Ser Tyr Ser Ser Asp Arg Ile Tyr Ser Leu 
 1105                1110                1115                1120
Ser Ser Asn Lys Pro Gln Arg Pro Val Phe Ser His Glu Asn Ile Gln 
                 1125                1130                1135
Gly Gly Gly Glu Pro Phe Gln Ala Leu Tyr Asn Tyr Thr Pro Arg Asn 
             1140                1145                1150
Glu Asp Glu Leu Glu Leu Arg Glu Ser Asp Val Val Asp Val Met Glu 
         1155                1160                1165
Lys Cys Asp Asp Gly Trp Phe Val Gly Thr Ser Arg Arg Thr Lys Phe 
     1170                1175                1180
Phe Gly Thr Phe Pro Gly Asn Tyr Val Lys Arg Leu 
 1185                1190                1195



<210> 586
<211> 1569
<212> DNA
<213> Homo sapiens
<308> AF396457
<400> 586

atgaaagca  caacacctt  gcagacagt  gaccggccc  aggactggt  caagacgat  60
tttaagcaa  ttcacatgg  gcacaagcc  gatgatgac  cagacatgt  taatactcc  120
acacctcac  tgaaatata  atacaatgc  ggtctgtac  acccaccct  cagtgctca  180
tcacaccct  ctgcaaaga  ccaaaccta  agacctctt  ccaaaagcc  ctccgacaa  240
agccccaat  cctttaagg  tgcgtcctc  ccagtgcct  ccccacatg  tccacctcc  300
gtcccgccg  ttcgaccaa  agatcggtc  tcaacagaa  agcatgact  ggatcctcc  360
gacagaaaa  tggacacaa  aaatttcgg  tctgagcca  ggagtattt  tgaatacga  420
gacagaaaa  tggacacga  aaaatttcg  tcggagcca  ggtctattt  tgaatacga  480
cctgggaag  catccatcc  gcagcacga  cgacccgtc  accagtctt  catagacag  540
agcttggaa  gacccagca  ctctgcaag  atggcgggt  actttagaa  acggaggaa  600
agtgaacct  cagtgggcc  gcccagggg  ttgggggat  acagttcaa  caggaccag  660
cccggccgg  cagacctcc  aggatcaag  tccaccttt  ccacgtctt  cattagttc  720
tctccttcc  ctccctcga  agcacaagg  ggggatgat  gcaaaatgt  tccgcccct  780
tgcagttac  cggggctca  tggctcgcc  tctagtgag  tagagtgct  cggcgctta  840
agaaggcac  tggacgtcc  ccaggactc  caaagggcc  tcactttca  gaacggctg  900
caaatggcc  ggcaaaatg  agagatctg  agtagcact  aagaggcgg  ttcccccaa  960
atcaaatca  gaagctgtg  cgatctcct  aatgatgac  gcggcagct  cccagaccc  1020
aaaaccaag  cagaaagca  gggttctct  ttatgtgac  aaggctcca  agagagcga  1080
cccatgacg  ggacttccc  ctacatccc  gaagtgtgc  ggaacagca  agaattcat  1140
ttaagcaaa  ggatattcg  ggaatctct  gatggagga  cattttgga  agtgctaaa  1200
gaatatcta  agcgagtga  gaatctatg  gaaagatgt  aagtgcaag  cgtaaattt  1260
ttggttgag  agatgatca  tgatttaaa  gtataacag  gtagatgcc  cccccctca  1320
aaacgcata  cccccccct  accctgaca  ttagctttg  atatgcaca  aatagtttg  1380
ggggagaat  gaaccctat  tctgaaagt  tatgtgttg  gatttcatc  catatatgg  1440
ggtagccgc  aactcagag  taggtcgtt  tgtaagatt  tcacaacaa  atgtataac  1500
caaacattc  tgagtcaaa  tgtacaaca  aaggtcacg  aaccgcaag  agggcgccg  1560
gataagtcc  1569



<210> 587
<211> 1100
<212> PRT
<213> Homo sapiens
<308> NP_066547
<400> 587

Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr Ser Leu Pro 
  1               5                  10                  15
Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly Thr Ser Leu Asp 
             20                  25                  30
Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp Gly Thr Thr 
         35                  40                  45
Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu Glu Lys Arg Val 
     50                  55                  60
Thr Val Ile Lys Ala Pro His Tyr Pro Gly Ile Gly Pro Val Asp Glu 
 65                  70                  75                  80
Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr Val Asp Arg Pro Lys Asp 
                 85                  90                  95
Trp Tyr Lys Thr Met Phe Lys Gln Ile His Met Val His Lys Pro Asp 
             100                105                110
Asp Asp Thr Asp Met Tyr Asn Thr Pro Tyr Thr Tyr Asn Ala Gly Leu 
         115                120                125
Tyr Asn Pro Pro Tyr Ser Ala Gln Ser His Pro Ala Ala Lys Thr Gln 
     130                135                140
Thr Tyr Arg Pro Leu Ser Lys Ser His Ser Asp Asn Ser Pro Asn Ala 
 145                150                155                160
Phe Lys Asp Ala Ser Ser Pro Val Pro Pro Pro His Val Pro Pro Pro 
                 165                170                175
Val Pro Pro Leu Arg Pro Arg Asp Arg Ser Ser Thr Glu Lys His Asp 
             180                185                190
Trp Asp Pro Pro Asp Arg Lys Val Asp Thr Arg Lys Phe Arg Ser Glu 
         195                200                205
Pro Arg Ser Ile Phe Glu Tyr Glu Pro Gly Lys Ser Ser Ile Leu Gln 
     210                215                220
His Glu Arg Pro Ala Ser Leu Tyr Gln Ser Ser Ile Asp Arg Ser Leu 
 225                230                235                240
Glu Arg Pro Met Ser Ser Ala Ser Met Ala Ser Asp Phe Arg Lys Arg 
                 245                250                255
Arg Lys Ser Glu Pro Ala Val Gly Pro Pro Arg Gly Leu Gly Asp Gln 
             260                265                270
Ser Ala Ser Arg Thr Ser Pro Gly Arg Val Asp Leu Pro Gly Ser Ser 
         275                280                285
Thr Thr Leu Thr Lys Ser Phe Thr Ser Ser Ser Pro Ser Ser Pro Ser 
     290                295                300
Arg Ala Lys Gly Gly Asp Asp Ser Lys Ile Cys Pro Ser Leu Cys Ser 
 305                310                315                320
Tyr Ser Gly Leu Asn Gly Asn Pro Ser Ser Glu Leu Asp Tyr Cys Ser 
                 325                330                335
Thr Tyr Arg Gln His Leu Asp Val Pro Arg Asp Ser Pro Arg Ala Ile 
             340                345                350
Ser Phe Lys Asn Gly Trp Gln Met Ala Arg Gln Asn Ala Glu Ile Trp 
         355                360                365
Ser Ser Thr Glu Glu Thr Val Ser Pro Lys Ile Lys Ser Arg Ser Cys 
     370                375                380
Asp Asp Leu Leu Asn Asp Asp Cys Asp Ser Phe Pro Asp Pro Lys Val 
 385                390                395                400
Lys Ser Glu Ser Met Gly Ser Leu Leu Cys Glu Glu Asp Ser Lys Glu 
                 405                410                415
Ser Cys Pro Met Ala Trp Gly Ser Pro Tyr Val Pro Glu Val Arg Ser 
             420                425                430
Asn Gly Arg Ser Arg Ile Arg His Arg Ser Ala Arg Asn Ala Pro Gly 
         435                440                445
Phe Leu Lys Met Tyr Lys Lys Met His Arg Ile Asn Arg Lys Asp Leu 
     450                455                460
Met Asn Ser Glu Val Ile Cys Ser Val Lys Ser Arg Ile Leu Gln Tyr 
 465                470                475                480
Glu Ser Glu Gln Gln His Lys Asp Leu Leu Arg Ala Trp Ser Gln Cys 
                 485                490                495
Ser Thr Glu Glu Val Pro Arg Asp Met Val Pro Thr Arg Ile Ser Glu 
             500                505                510
Phe Glu Lys Leu Ile Gln Lys Ser Lys Ser Met Pro Asn Leu Gly Asp 
         515                520                525
Asp Met Leu Ser Pro Val Thr Leu Glu Pro Pro Gln Asn Gly Leu Cys 
     530                535                540
Pro Lys Arg Arg Phe Ser Ile Glu Tyr Leu Leu Glu Glu Glu Asn Gln 
 545                550                555                560
Ser Gly Pro Pro Ala Arg Gly Arg Arg Gly Cys Gln Ser Asn Ala Leu 
                 565                570                575
Val Pro Ile His Ile Glu Val Thr Ser Asp Glu Gln Pro Arg Ala His 
             580                585                590
Val Glu Phe Ser Asp Ser Asp Gln Asp Gly Val Val Ser Asp His Ser 
         595                600                605
Asp Tyr Ile His Leu Glu Gly Ser Ser Phe Cys Ser Glu Ser Asp Phe 
     610                615                620
Asp His Phe Ser Phe Thr Ser Ser Glu Ser Phe Tyr Gly Ser Ser His 
 625                630                635                640
His His His His His His His His His His Arg His Leu Ile Ser Ser 
                 645                650                655
Cys Lys Gly Arg Cys Pro Ala Ser Tyr Thr Arg Phe Thr Thr Met Leu 
             660                665                670
Lys His Glu Arg Ala Arg His Glu Asn Thr Glu Glu Pro Arg Arg Gln 
         675                680                685
Glu Met Asp Pro Gly Leu Ser Lys Leu Ala Phe Leu Val Ser Pro Val 
     690                695                700
Pro Phe Arg Arg Lys Lys Asn Ser Ala Pro Lys Lys Gln Thr Glu Lys 
 705                710                715                720
Ala Lys Cys Lys Ala Ser Val Phe Glu Ala Leu Asp Ser Ala Leu Lys 
                 725                730                735
Asp Ile Cys Asp Gln Ile Lys Ala Glu Lys Lys Arg Gly Ser Leu Pro 
             740                745                750
Asp Asn Ser Ile Leu His Arg Leu Ile Ser Glu Leu Leu Pro Asp Val 
         755                760                765
Pro Glu Arg Asn Ser Ser Leu Arg Ala Leu Arg Arg Ser Pro Leu His 
     770                775                780
Gln Pro Leu His Pro Leu Pro Pro Asp Gly Ala Ile His Cys Pro Pro 
 785                790                795                800
Tyr Gln Asn Asp Cys Gly Arg Met Pro Arg Ser Ala Ser Phe Gln Asp 
                 805                810                815
Val Asp Thr Ala Asn Ser Ser Cys His His Gln Asp Arg Gly Gly Ala 
             820                825                830
Leu Gln Asp Arg Glu Ser Pro Arg Ser Tyr Ser Ser Thr Leu Thr Asp 
         835                840                845
Met Gly Arg Ser Ala Pro Arg Glu Arg Arg Gly Thr Pro Glu Lys Glu 
     850                855                860
Lys Leu Pro Ala Lys Ala Val Tyr Asp Phe Lys Ala Gln Thr Ser Lys 
 865                870                875                880
Glu Leu Ser Phe Lys Lys Gly Asp Thr Val Tyr Ile Leu Arg Lys Ile 
                 885                890                895
Asp Gln Asn Trp Tyr Glu Gly Glu His His Gly Arg Val Gly Ile Phe 
             900                905                910
Pro Ile Ser Tyr Val Glu Lys Leu Thr Pro Pro Glu Lys Ala Gln Pro 
         915                920                925
Ala Arg Pro Pro Pro Pro Ala Gln Pro Gly Glu Ile Gly Glu Ala Ile 
     930                935                940
Ala Lys Tyr Asn Phe Asn Ala Asp Thr Asn Val Glu Leu Ser Leu Arg 
 945                950                955                960
Lys Gly Asp Arg Val Ile Leu Leu Lys Arg Val Asp Gln Asn Trp Tyr 
                 965                970                975
Glu Gly Lys Ile Pro Gly Thr Asn Arg Gln Gly Ile Phe Pro Val Ser 
             980                985                990
Tyr Val Glu Val Val Lys Lys Asn Thr Lys Gly Ala Glu Asp Tyr Pro 
         995                1000                1005
Asp Pro Pro Ile Pro His Ser Tyr Ser Ser Asp Arg Ile His Ser Leu 
     1010                1015                1020
Ser Ser Asn Lys Pro Gln Arg Pro Val Phe Thr His Glu Asn Ile Gln 
 1025                1030                1035                1040
Gly Gly Gly Glu Pro Phe Gln Ala Leu Tyr Asn Tyr Thr Pro Arg Asn 
                 1045                1050                1055
Glu Asp Glu Leu Glu Leu Arg Glu Ser Asp Val Ile Asp Val Met Glu 
             1060                1065                1070
Lys Cys Asp Asp Gly Trp Phe Val Gly Thr Ser Arg Arg Thr Lys Phe 
         1075                1080                1085
Phe Gly Thr Phe Pro Gly Asn Tyr Val Lys Arg Leu 
     1090                1095                1100



<210> 588
<211> 1242
<212> DNA
<213> Rattus norvegicus
<308> AF026529
<400> 588

ggcacgaga  gagaacaga  cgctttgga  accggactg  aggattgtg  tccagttct  60
agctggtga  aaacactcc  tgtgacttt  ggtcaattc  gctaccaga  tccagccaa  120
atgaccctc  cagcctata  ggagaagat  aaggaactc  cactagtgt  tctgttctg  180
tcctgtttt  tgtctgatc  cctgaataa  tcatcctac  aatatgaag  agatacggt  240
gacctgaac  ggtgtgtca  ctctgatat  gaagtcatc  agctgaata  gtgtacctc  300
ggccagtcc  ttgaagtca  cctgaagcc  ccttccttt  acggggtgc  tgagtttaa  360
gcctccctc  caagacgtc  agacccatc  ctagaagag  tacagaaga  gctagaagc  420
gcagaggag  gaaggaagt  ccaggaagc  gagctccta  aacaccttg  agagaaacg  480
gagcatgag  gtgaggtaa  ccagaaagc  atcgaggaa  acaacaact  catcaagat  540
gcgaaagag  agctggccc  gaagatgga  tccaataag  aaaaccggg  ggcccatct  600
gctgccatg  tggagcggc  gcaagagaa  gagccgcct  ctgcgcggt  actcccggg  660
ccgatcggt  gcctcgtcc  atggacaag  acgcagagg  ggtgcggaa  aacaaggag  720
tgaaggaag  ggcctccag  taaagccca  aggccaagg  agtttccag  acagccgga  780
agctcccgc  gcaacctgg  tccagcagc  tcggccgct  gctgctctc  cagcactgg  840
gttcggggg  aggggggtg  ccaaagggg  gtttcctct  cttttggtg  ttgtacatg  900
aaaagattg  ccagtgaag  catcctatt  gtttctggg  aacaatgat  gggtggaga  960
gggacagag  gtgtgtgga  aaggaggtg  agatgaccc  aggactttg  acactgtcc  1020
ctgactgca  acttgccaa  gcccccgct  ttcagcctc  gcctggaca  tcggcctcc  1080
ggttcctag  ggagagaag  tgtgacaga  gttcagagt  aagggccga  tcctggtgg  1140
gtggtgtgc  gggccagca  gacgagccc  tctggatgg  gtgaaacct  cctgagcgg  1200
tgggataag  tctgtgtgc  tctgttcat  gtcatcttt  ct  1242



<210> 589
<211> 189
<212> PRT
<213> Rattus norvegicus
<308> O35414
<400> 589

Met Thr Leu Ala Ala Tyr Lys Glu Lys Met Lys Glu Leu Pro Leu Val 
  1               5                  10                  15
Ser Leu Phe Cys Ser Cys Phe Leu Ser Asp Pro Leu Asn Lys Ser Ser 
             20                  25                  30
Tyr Lys Tyr Glu Ala Asp Thr Val Asp Leu Asn Trp Cys Val Ile Ser 
         35                  40                  45
Asp Met Glu Val Ile Glu Leu Asn Lys Cys Thr Ser Gly Gln Ser Phe 
     50                  55                  60
Glu Val Ile Leu Lys Pro Pro Ser Phe Asp Gly Val Pro Glu Phe Asn 
 65                  70                  75                  80
Ala Ser Leu Pro Arg Arg Arg Asp Pro Ser Leu Glu Glu Ile Gln Lys 
                 85                  90                  95
Lys Leu Glu Ala Ala Glu Glu Arg Arg Lys Tyr Gln Glu Ala Glu Leu 
             100                105                110
Leu Lys His Leu Ala Glu Lys Arg Glu His Glu Arg Glu Val Ile Gln 
         115                120                125
Lys Ala Ile Glu Glu Asn Asn Asn Phe Ile Lys Met Ala Lys Glu Lys 
     130                135                140
Leu Ala Gln Lys Met Glu Ser Asn Lys Glu Asn Arg Glu Ala His Leu 
 145                150                155                160
Ala Ala Met Leu Glu Arg Leu Gln Glu Lys Asp Lys His Ala Glu Glu 
                 165                170                175
Val Arg Lys Asn Lys Glu Leu Lys Glu Glu Ala Ser Arg 
             180                185



<210> 590
<211> 694
<212> DNA
<213> Homo sapiens
<308> AJ303455
<400> 590

ttggtgaca  cgtcccaag  tggtgacag  cccactctg  aactttcag  tagattcag  60
caccagatc  cagaaacat  acccttgct  cctacaaag  gaagatgaa  gagctcccg  120
tggtgtcct  gttctgctc  tgcttcctg  ccgatcccc  gaataagtc  tcctacaaa  180
atgaagcag  cacggtgga  ctgaattgg  gcgtcattt  cgacatgga  gtcatcgag  240
tgaacaaat  cacctcggg  caatccttt  aagtcatcc  gaagccacc  tcctttgat  300
gggttcccg  gttcaacgc  tccctgcca  ggcggcgag  cccatccct  gaagagatc  360
agaagaaac  agaagcggc  gaggagcga  ggaagtacc  ggaagcgga  ctcctgaaa  420
acctagcag  gaaacggga  catgagaga  aggtgatcc  aaaggccat  gaggaaaac  480
acaacttca  caagatggc  aaggaaaaa  tggcccaga  gatggaatc  aacaaggag  540
acagggagg  ccacctcgc  gccatgttg  aacggctgc  agagaagga  aagcacgcc  600
aggaggtgc  gaaaaacaa  gagctgaag  aagaggcct  caggtaaag  ctagaggcc  660
aagaacttt  caggtcagc  ggacagctc  agca  694



<210> 591
<211> 189
<212> PRT
<213> Homo sapiens
<308> Q9H169
<400> 591

Met Thr Leu Ala Ala Tyr Lys Glu Lys Met Lys Glu Leu Pro Leu Val 
  1               5                  10                  15
Ser Leu Phe Cys Ser Cys Phe Leu Ala Asp Pro Leu Asn Lys Ser Ser 
             20                  25                  30
Tyr Lys Tyr Glu Ala Asp Thr Val Asp Leu Asn Trp Cys Val Ile Ser 
         35                  40                  45
Asp Met Glu Val Ile Glu Leu Asn Lys Cys Thr Ser Gly Gln Ser Phe 
     50                  55                  60
Glu Val Ile Leu Lys Pro Pro Ser Phe Asp Gly Val Pro Glu Phe Asn 
 65                  70                  75                  80
Ala Ser Leu Pro Arg Arg Arg Asp Pro Ser Leu Glu Glu Ile Gln Lys 
                 85                  90                  95
Lys Leu Glu Ala Ala Glu Glu Arg Arg Lys Tyr Gln Glu Ala Glu Leu 
             100                105                110
Leu Lys His Leu Ala Glu Lys Arg Glu His Glu Arg Glu Val Ile Gln 
         115                120                125
Lys Ala Ile Glu Glu Asn Asn Asn Phe Ile Lys Met Ala Lys Glu Lys 
     130                135                140
Leu Ala Gln Lys Met Glu Ser Asn Lys Glu Asn Arg Glu Ala His Leu 
 145                150                155                160
Ala Ala Met Leu Glu Arg Leu Gln Glu Lys Asp Lys His Ala Glu Glu 
                 165                170                175
Val Arg Lys Asn Lys Glu Leu Lys Glu Glu Ala Ser Arg 
             180                185



<210> 592
<211> 3091
<212> DNA
<213> Rattus norvegicus
<308> AF026554
<400> 592

gttcgccac  tgtggagag  agggaaaaa  tgagccgag  gagggggga  aaaaaccaa  60
gctgatttc  gaaagaacg  aggaacttc  gtagccctg  ccgaaccac  gacgcaagg  120
aggtagcgc  tccgcagag  ggcagcagt  ctgactgga  gggcgctcg  tgggagaga  180
ccatcacac  taaggggac  gctattgct  tgggtgacg  ctcctaaaa  gagaatcgg  240
gcctctacc  ctccacgta  ctctgcttc  gaacgggga  tgcttctcc  gctccccct  300
gaccatgcc  ctgggtgga  gaggaacgc  gagaggctg  gcgaggaac  agctaggtg  360
caactcaga  cccaggagt  ccaagtcac  gtaaagcat  ggcaccgtg  ggatgactg  420
ggcgagcac  gcggctccc  cctatacaa  ctcagacac  aaccgggtt  tttccacct  480
ttctgttgt  gactatgtg  tgtttggcc  gttgctggt  ctctccctt  tcattgggc  540
ctatcatgc  tgccgaggc  ggggccgcc  tactgttgg  gagctgctg  tggcagacc  600
aaaaatggg  tgccttcct  tggcactgt  cttgctggc  accttccag  cagccgtgg  660
gatccttgg  ggaccagct  agatctacc  atttggaac  cagtattgg  tcctggggt  720
ctcctactt  ctggggctt  tgatccctg  tcacatctt  atccctgtc  tctaccgcc  780
gcatcttac  agcgcctat  agtacctag  gctccgctt  aataaagca  tccggatct  840
tgggactgt  accttcatc  ttcagatgg  ggtctacat  ggagtggct  tctatgcac  900
gtccctggc  ctcaatgca  tgactggat  tgatctatg  ctgtcagtc  tggccctag  960
aattgtctg  aacatctac  ctgcactgg  tgggctgaa  gctgtcatc  ggacagatg  1020
gttccaaac  ttgatcatg  tcctagggc  gctggtggt  atcattgta  gagcggcca  1080
agtgggcgg  ttggggcat  tatgggctg  ggcttccca  catggcctc  tctctggga  1140
tgagctgga  cctgacccc  ttgtacgtc  tactttctg  actttggcc  ttggcggcg  1200
cttcatgat  ctctcctta  atggagtga  tcaggctca  gtgcagcgc  acctcagtt  1260
ccactcaga  aaggctgct  tgctctcct  ctatgcagt  ttcccttgc  agcaagtgg  1320
cctctgcat  agctgcctc  ttggtctgg  catgtttgc  tattataag  aatatagta  1380
gagccccca  caagagcaa  cagcccctg  ccagttagt  ctctatttt  tgatggacc  1440
cctgaaaga  atgccaggg  tgcccgggc  cttcgttgc  tgcctcttc  gtggatctc  1500
cagcaccat  tcctccgca  tcaattcac  ggccactgt  acaatggaa  acctgatcc  1560
gccctggtt  cctcagttg  ctgaaaccc  ggccatcat  ctctctcga  gccttgcct  1620
tgcctatgg  ctagtttgc  tgggaatgg  ctatgtttc  tctcatctg  gatcagtgc  1680
ccaggcagc  ctcagcatc  ttggcatgg  tggagggcc  ctgctggga  tcttctgcc  1740
tgggatgtt  tttccgtgt  ccaaccctc  tggtgccat  gtaggcctg  tgacgggac  1800
caccatggc  ttctggatt  gcattggga  catagtaag  aggatgagt  ctgctgcag  1860
atcccctcc  cttaatgga  ccagctcct  cctgcccag  aatctaact  tcgccactg  1920
gaccaccct  atgccttct  ccctgtcca  gcccacagg  ctgcagcag  tctattccc  1980
gtcctattt  tggtacagt  cgcacaact  caccacagt  attgcagtg  gcctgattg  2040
cagtctgct  actggggga  tgcggggcc  gtccctgaa  cctggcacc  tttaccctg  2100
gttgccaaa  ctccttgca  tcctgccct  atcctgcca  aagcggctt  gctggagaa  2160
ccacaacca  gatatccct  tggtcacca  cctgtttcc  gagaagatg  ggaacggag  2220
gctgcagga  agcagagac  aagagagga  ggctgaaga  ggccttgtc  atcagccat  2280
cagccccac  tacattgtc  aagagacgt  cctgtgacc  gtgacggac  tctcactgc  2340
gagcagtgg  cagagatac  ctggagtgc  gagctgagt  actgcatga  ttccgcagc  2400
ctggggtgg  tgacctagc  cacagcaaa  gaccttgat  tttaatgtt  caccgccgt  2460
ggagctgtc  catgcaagg  acagacagt  tttccttat  ccttgccag  cttctttta  2520
gatcaggtt  gcaaggtac  gaatcacag  acacgtggg  aaatatact  aggaaaggg  2580
ggcttttga  taagtgacc  gggttcttt  gggtgaata  gaacatttc  tacaactcc  2640
cttgagcaa  tttggcagg  ttgaccagc  ccagcattt  gcatgaagt  ctcagccct  2700
tggtgattc  ctcactctc  tgtcaacct  ggttatctc  agccagtgt  ggcctgtgg  2760
cttcaggtt  tctgtaaga  tcaagtctc  tctcattct  cctacctct  tttgtgaga  2820
ggaggcttt  gagcgcttg  gtctcagca  ttagtgcat  tacttggtg  atagaccct  2880
gctctcttc  ggtggtaca  gagagacag  tacatgaga  aggtcacca  gacctctta  2940
gcagtgtgc  atcctctaa  ctcctaagc  aggccaccc  ggtgtcatt  tgtcatctg  3000
gcaattctt  tttcctttg  gagtttcct  ctcatgcat  ttgttccta  ggaataaaa  3060
tagccatta  acctgaaaa  aaaaaaaaa  a  3091



<210> 593
<211> 634
<212> PRT
<213> Rattus norvegicus
<308> O70247
<400> 593

Met Thr Val Ala Ser Thr Ala Ala Pro Ser Tyr Thr Thr Ser Asp Thr 
  1               5                  10                  15
Asn Arg Val Ile Ser Thr Phe Ser Val Val Asp Tyr Val Val Phe Gly 
             20                  25                  30
Leu Leu Leu Val Leu Ser Leu Val Ile Gly Leu Tyr His Ala Cys Arg 
         35                  40                  45
Gly Trp Gly Arg His Thr Val Gly Glu Leu Leu Met Ala Asp Arg Lys 
     50                  55                  60
Met Gly Cys Leu Pro Val Ala Leu Ser Leu Leu Ala Thr Phe Gln Ser 
 65                  70                  75                  80
Ala Val Ala Ile Leu Gly Gly Pro Ala Glu Ile Tyr Arg Phe Gly Thr 
                 85                  90                  95
Gln Tyr Trp Phe Leu Gly Cys Ser Tyr Phe Leu Gly Leu Leu Ile Pro 
             100                105                110
Ala His Ile Phe Ile Pro Val Phe Tyr Arg Leu His Leu Thr Ser Ala 
         115                120                125
Tyr Glu Tyr Leu Glu Leu Arg Phe Asn Lys Ala Val Arg Ile Cys Gly 
     130                135                140
Thr Val Thr Phe Ile Phe Gln Met Val Val Tyr Met Gly Val Ala Leu 
 145                150                155                160
Tyr Ala Pro Ser Leu Ala Leu Asn Ala Val Thr Gly Phe Asp Leu Trp 
                 165                170                175
Leu Ser Val Leu Ala Leu Gly Ile Val Cys Asn Ile Tyr Thr Ala Leu 
             180                185                190
Gly Gly Leu Lys Ala Val Ile Trp Thr Asp Val Phe Gln Thr Leu Ile 
         195                200                205
Met Phe Leu Gly Gln Leu Val Val Ile Ile Val Gly Ala Ala Lys Val 
     210                215                220
Gly Gly Leu Gly His Val Trp Ala Val Ala Ser Gln His Gly Leu Ile 
 225                230                235                240
Ser Gly Ile Glu Leu Asp Pro Asp Pro Phe Val Arg His Thr Phe Trp 
                 245                250                255
Thr Leu Ala Phe Gly Gly Val Phe Met Met Leu Ser Leu Tyr Gly Val 
             260                265                270
Asn Gln Ala Gln Val Gln Arg Tyr Leu Ser Ser His Ser Glu Lys Ala 
         275                280                285
Ala Val Leu Ser Cys Tyr Ala Val Phe Pro Cys Gln Gln Val Ala Leu 
     290                295                300
Cys Met Ser Cys Leu Ile Gly Leu Val Met Phe Ala Tyr Tyr Lys Lys 
 305                310                315                320
Tyr Ser Met Ser Pro Gln Gln Glu Gln Ala Ala Pro Asp Gln Leu Val 
                 325                330                335
Leu Tyr Phe Val Met Asp Leu Leu Lys Asp Met Pro Gly Leu Pro Gly 
             340                345                350
Leu Phe Val Ala Cys Leu Phe Ser Gly Ser Leu Ser Thr Ile Ser Ser 
         355                360                365
Ala Phe Asn Ser Leu Ala Thr Val Thr Met Glu Asp Leu Ile Gln Pro 
     370                375                380
Trp Phe Pro Gln Leu Thr Glu Thr Arg Ala Ile Met Leu Ser Arg Ser 
 385                390                395                400
Leu Ala Phe Ala Tyr Gly Leu Val Cys Leu Gly Met Ala Tyr Val Ser 
                 405                410                415
Ser His Leu Gly Ser Val Leu Gln Ala Ala Leu Ser Ile Phe Gly Met 
             420                425                430
Val Gly Gly Pro Leu Leu Gly Leu Phe Cys Leu Gly Met Phe Phe Pro 
         435                440                445
Cys Ala Asn Pro Leu Gly Ala Ile Val Gly Leu Leu Thr Gly Leu Thr 
     450                455                460
Met Ala Phe Trp Ile Gly Ile Gly Ser Ile Val Ser Arg Met Ser Ser 
 465                470                475                480
Ala Ala Ala Ser Pro Pro Leu Asn Gly Ser Ser Ser Phe Leu Pro Ser 
                 485                490                495
Asn Leu Thr Val Ala Thr Val Thr Thr Leu Met Pro Ser Thr Leu Ser 
             500                505                510
Lys Pro Thr Gly Leu Gln Gln Phe Tyr Ser Leu Ser Tyr Leu Trp Tyr 
         515                520                525
Ser Ala His Asn Ser Thr Thr Val Ile Ala Val Gly Leu Ile Val Ser 
     530                535                540
Leu Leu Thr Gly Gly Met Arg Gly Arg Ser Leu Asn Pro Gly Thr Ile 
 545                550                555                560
Tyr Pro Val Leu Pro Lys Leu Leu Ala Leu Leu Pro Leu Ser Cys Gln 
                 565                570                575
Lys Arg Leu Cys Trp Arg Ser His Asn Gln Asp Ile Pro Val Val Thr 
             580                585                590
Asn Leu Phe Pro Glu Lys Met Gly Asn Gly Ala Leu Gln Asp Ser Arg 
         595                600                605
Asp Lys Glu Arg Met Ala Glu Asp Gly Leu Val His Gln Pro Cys Ser 
     610                615                620
Pro Thr Tyr Ile Val Gln Glu Thr Ser Leu 
 625                630



<210> 594
<211> 2310
<212> DNA
<213> Homo sapiens
<308> AL096737
<400> 594

gtcacatag  agtgaggac  tggtgggag  aagctgggg  gtgatgtaa  atgcctttt  60
tttccagag  gacagaggt  gtagtttgg  tgggcaggg  gccttgctt  accccattg  120
ttgtgttaa  tcacacctt  ttgtttcct  tcctgtcct  ttcccccag  ctttggcta  180
gggctgctt  gtctaggaa  ggcctatat  tcctcccag  tgggacctg  gctgcaggc  240
gcaatcagc  tctttggca  ggttggggg  ccgctgctg  gactcttct  ccttggaat  300
ttctttcca  gtgctaacc  tcctgtgag  gatgcatct  gatccacag  catgtgtag  360
aggatggac  tgggggttg  cagggctgt  accaggaga  ctgaggact  ccgtgaggg  420
tggcaggac  ggccttgtg  caggcctgc  ctgtgtctc  gcagggtgc  gttgtgggc  480
tgttggctg  gctcgtcat  gccttctgg  ttggcatcg  gagcatcgt  accagcatg  540
gcttcagca  gccaccctc  ccctctaat  ggtccagct  ctccctgcc  accaatcta  600
ccgttgcca  tgtgaccac  ctgatgccc  tgactacct  ctccaagta  ggcagggct  660
gctatcttc  tgttttctc  aagtcctcc  ttgagggct  tcacagggg  cttgctaag  720
gatgggcca  cagaggccc  agggaaatg  tgggtattg  gtcccaaga  cctgggacc  780
tgcgggcaa  tagagattg  tgcccaagg  atgccctgc  aacgaattg  taattgttc  840
cacctctgc  cttcccagg  ccacagggc  gcagcggtt  tattccttg  cttacttat  900
gtacagtgc  cacaactcc  ccacagtga  tgtggtggg  ctgattgtc  gtctactca  960
tggtaaggg  gtgggattg  ggtgcagat  agcaccgag  gttaacaga  ggccctaag  1020
gactctagg  agaaaggct  ctgccctct  agctcttgg  tgtccgtag  tgtcaggct  1080
ttctgctgg  atgtaggag  tgggtgggg  ctggggtct  tgggggcca  gggaggaca  1140
ggggcccgc  gctgtggat  gttccaccc  gagactcag  agcacattt  cattcaggg  1200
gaatgcgag  ccggtccct  aaccctgca  ccatttacc  agtgttgcc  aagctcctg  1260
ccctccttc  gttgtcctg  cagaagcgg  tccactgca  gagctacgg  caggaccac  1320
tcgacactg  cctgtttcc  gagaagccg  ggaatggtg  gctggggga  agcagagac  1380
aggaggcca  ggccctgga  ggcacagcc  atcagggga  cagctccac  tgcatcctc  1440
aggagacct  cctgtgatg  tgactcagg  ccccgcctc  gtcctcact  tgccaggcc  1500
tagccagag  ccaccctgt  gtacaggga  gagtcttgg  gtgttctgc  gggacaggc  1560
tggatgatc  agctcatac  aaaggacct  gttctgaga  gttcttgcc  gcaggagaa  1620
ctgtcacat  tcaagcatg  gaggcaccg  ttttctcgt  gcttgccaa  ctgtttttt  1680
aaggatcag  ctcgtaggg  gcaggatca  gccagaaat  gggatggaa  tgcatcctc  1740
gggaaaaag  taatggctt  tgattcaac  tagccatag  cctttgaag  aagtggcta  1800
aaacagcac  ctggttata  ttgccccag  gcctgattc  ggactgact  tccaccata  1860
aactggaag  tgcttcccc  gtagtcccc  tttcagtac  agttctgcc  gccacagtg  1920
gcccctatt  ttactttca  attgtctgt  acactcaag  ccctctcat  tttatctgt  1980
tacctccat  ctgaagagg  aggttttgg  gtccctggt  ctctgggaa  agaagatcc  2040
tttgtcttt  tgtagagca  gcacgtttt  cacctcact  tctccatcc  ccacctctg  2100
gatggacac  taagagacg  ggcaaatgt  gatccaaga  accagggcc  tgaccaggt  2160
cactgtgga  cagccatct  tctacctga  tcctgagcc  ggctgccgt  gtgtcattt  2220
tgtcatccg  gctctgttt  cttttggag  ttcttctcc  cattatctt  gttcctggg  2280
aataaaaac  accattgga  ctagaaaaaa  2310



<210> 595
<211> 635
<212> PRT
<213> Homo sapiens
<308> Q9Y289
<400> 595

Met Ser Val Gly Val Ser Thr Ser Ala Pro Leu Ser Pro Thr Ser Gly 
  1               5                  10                  15
Thr Ser Val Gly Met Ser Thr Phe Ser Ile Met Asp Tyr Val Val Phe 
             20                  25                  30
Val Leu Leu Leu Val Leu Ser Leu Ala Ile Gly Leu Tyr His Ala Cys 
         35                  40                  45
Arg Gly Trp Gly Arg His Thr Val Gly Glu Leu Leu Met Ala Asp Arg 
     50                  55                  60
Lys Met Gly Cys Leu Pro Val Ala Leu Ser Leu Leu Ala Thr Phe Gln 
 65                  70                  75                  80
Ser Ala Val Ala Ile Leu Gly Val Pro Ser Glu Ile Tyr Arg Phe Gly 
                 85                  90                  95
Thr Gln Tyr Trp Phe Leu Gly Cys Cys Tyr Phe Leu Gly Leu Leu Ile 
             100                105                110
Pro Ala His Ile Phe Ile Pro Val Phe Tyr Arg Leu His Leu Thr Ser 
         115                120                125
Ala Tyr Glu Tyr Leu Glu Leu Arg Phe Asn Lys Thr Val Arg Val Cys 
     130                135                140
Gly Thr Val Thr Phe Ile Phe Gln Met Val Ile Tyr Met Gly Val Val 
 145                150                155                160
Leu Tyr Ala Pro Ser Leu Ala Leu Asn Ala Val Thr Gly Phe Asp Leu 
                 165                170                175
Trp Leu Ser Val Leu Ala Leu Gly Ile Val Cys Thr Val Tyr Thr Ala 
             180                185                190
Leu Gly Gly Leu Lys Ala Val Ile Trp Thr Asp Val Phe Gln Thr Leu 
         195                200                205
Val Met Phe Leu Gly Gln Leu Ala Val Ile Ile Val Gly Ser Ala Lys 
     210                215                220
Val Gly Gly Leu Gly Arg Val Trp Ala Val Ala Ser Gln His Gly Arg 
 225                230                235                240
Ile Ser Gly Phe Glu Leu Asp Pro Asp Pro Phe Val Arg His Thr Phe 
                 245                250                255
Trp Thr Leu Ala Phe Gly Gly Val Phe Met Met Leu Ser Leu Tyr Gly 
             260                265                270
Val Asn Gln Ala Gln Val Gln Arg Tyr Leu Ser Ser Arg Thr Glu Lys 
         275                280                285
Ala Ala Val Leu Ser Cys Tyr Ala Val Phe Pro Phe Gln Gln Val Ser 
     290                295                300
Leu Cys Val Gly Cys Leu Ile Gly Leu Val Met Phe Ala Tyr Tyr Gln 
 305                310                315                320
Glu Tyr Pro Met Ser Ile Gln Gln Ala Gln Ala Ala Pro Asp Gln Phe 
                 325                330                335
Val Leu Tyr Phe Val Met Asp Leu Leu Lys Gly Leu Pro Gly Leu Pro 
             340                345                350
Gly Leu Phe Ile Ala Cys Leu Phe Ser Gly Ser Leu Ser Thr Ile Ser 
         355                360                365
Ser Ala Phe Asn Ser Leu Ala Thr Val Thr Met Glu Asp Leu Ile Arg 
     370                375                380
Pro Trp Phe Pro Glu Phe Ser Glu Ala Arg Ala Ile Met Leu Ser Arg 
 385                390                395                400
Gly Leu Ala Phe Gly Tyr Gly Leu Leu Cys Leu Gly Met Ala Tyr Ile 
                 405                410                415
Ser Ser Gln Met Gly Pro Val Leu Gln Ala Ala Ile Ser Ile Phe Gly 
             420                425                430
Met Val Gly Gly Pro Leu Leu Gly Leu Phe Cys Leu Gly Met Phe Phe 
         435                440                445
Pro Cys Ala Asn Pro Pro Gly Ala Val Val Gly Leu Leu Ala Gly Leu 
     450                455                460
Val Met Ala Phe Trp Ile Gly Ile Gly Ser Ile Val Thr Ser Met Gly 
 465                470                475                480
Phe Ser Met Pro Pro Ser Pro Ser Asn Gly Ser Ser Phe Ser Leu Pro 
                 485                490                495
Thr Asn Leu Thr Val Ala Thr Val Thr Thr Leu Met Pro Leu Thr Thr 
             500                505                510
Phe Ser Lys Pro Thr Gly Leu Gln Arg Phe Tyr Ser Leu Ser Tyr Leu 
         515                520                525
Trp Tyr Ser Ala His Asn Ser Thr Thr Val Ile Val Val Gly Leu Ile 
     530                535                540
Val Ser Leu Leu Thr Gly Arg Met Arg Gly Arg Ser Leu Asn Pro Ala 
 545                550                555                560
Thr Ile Tyr Pro Val Leu Pro Lys Leu Leu Ser Leu Leu Pro Leu Ser 
                 565                570                575
Cys Gln Lys Arg Leu His Cys Arg Ser Tyr Gly Gln Asp His Leu Asp 
             580                585                590
Thr Gly Leu Phe Pro Glu Lys Pro Arg Asn Gly Val Leu Gly Asp Ser 
         595                600                605
Arg Asp Lys Glu Ala Met Ala Leu Asp Gly Thr Ala Tyr Gln Gly Ser 
     610                615                620
Ser Ser Thr Cys Ile Leu Gln Glu Thr Ser Leu 
 625                630                635



<210> 596
<211> 3091
<212> DNA
<213> Rattus norvegicus
<308> AF026554
<400> 596

gttcgccac  tgtggagag  agggaaaaa  tgagccgag  gagggggga  aaaaaccaa  60
gctgatttc  gaaagaacg  aggaacttc  gtagccctg  ccgaaccac  gacgcaagg  120
aggtagcgc  tccgcagag  ggcagcagt  ctgactgga  gggcgctcg  tgggagaga  180
ccatcacac  taaggggac  gctattgct  tgggtgacg  ctcctaaaa  gagaatcgg  240
gcctctacc  ctccacgta  ctctgcttc  gaacgggga  tgcttctcc  gctccccct  300
gaccatgcc  ctgggtgga  gaggaacgc  gagaggctg  gcgaggaac  agctaggtg  360
caactcaga  cccaggagt  ccaagtcac  gtaaagcat  ggcaccgtg  ggatgactg  420
ggcgagcac  gcggctccc  cctatacaa  ctcagacac  aaccgggtt  tttccacct  480
ttctgttgt  gactatgtg  tgtttggcc  gttgctggt  ctctccctt  tcattgggc  540
ctatcatgc  tgccgaggc  ggggccgcc  tactgttgg  gagctgctg  tggcagacc  600
aaaaatggg  tgccttcct  tggcactgt  cttgctggc  accttccag  cagccgtgg  660
gatccttgg  ggaccagct  agatctacc  atttggaac  cagtattgg  tcctggggt  720
ctcctactt  ctggggctt  tgatccctg  tcacatctt  atccctgtc  tctaccgcc  780
gcatcttac  agcgcctat  agtacctag  gctccgctt  aataaagca  tccggatct  840
tgggactgt  accttcatc  ttcagatgg  ggtctacat  ggagtggct  tctatgcac  900
gtccctggc  ctcaatgca  tgactggat  tgatctatg  ctgtcagtc  tggccctag  960
aattgtctg  aacatctac  ctgcactgg  tgggctgaa  gctgtcatc  ggacagatg  1020
gttccaaac  ttgatcatg  tcctagggc  gctggtggt  atcattgta  gagcggcca  1080
agtgggcgg  ttggggcat  tatgggctg  ggcttccca  catggcctc  tctctggga  1140
tgagctgga  cctgacccc  ttgtacgtc  tactttctg  actttggcc  ttggcggcg  1200
cttcatgat  ctctcctta  atggagtga  tcaggctca  gtgcagcgc  acctcagtt  1260
ccactcaga  aaggctgct  tgctctcct  ctatgcagt  ttcccttgc  agcaagtgg  1320
cctctgcat  agctgcctc  ttggtctgg  catgtttgc  tattataag  aatatagta  1380
gagccccca  caagagcaa  cagcccctg  ccagttagt  ctctatttt  tgatggacc  1440
cctgaaaga  atgccaggg  tgcccgggc  cttcgttgc  tgcctcttc  gtggatctc  1500
cagcaccat  tcctccgca  tcaattcac  ggccactgt  acaatggaa  acctgatcc  1560
gccctggtt  cctcagttg  ctgaaaccc  ggccatcat  ctctctcga  gccttgcct  1620
tgcctatgg  ctagtttgc  tgggaatgg  ctatgtttc  tctcatctg  gatcagtgc  1680
ccaggcagc  ctcagcatc  ttggcatgg  tggagggcc  ctgctggga  tcttctgcc  1740
tgggatgtt  tttccgtgt  ccaaccctc  tggtgccat  gtaggcctg  tgacgggac  1800
caccatggc  ttctggatt  gcattggga  catagtaag  aggatgagt  ctgctgcag  1860
atcccctcc  cttaatgga  ccagctcct  cctgcccag  aatctaact  tcgccactg  1920
gaccaccct  atgccttct  ccctgtcca  gcccacagg  ctgcagcag  tctattccc  1980
gtcctattt  tggtacagt  cgcacaact  caccacagt  attgcagtg  gcctgattg  2040
cagtctgct  actggggga  tgcggggcc  gtccctgaa  cctggcacc  tttaccctg  2100
gttgccaaa  ctccttgca  tcctgccct  atcctgcca  aagcggctt  gctggagaa  2160
ccacaacca  gatatccct  tggtcacca  cctgtttcc  gagaagatg  ggaacggag  2220
gctgcagga  agcagagac  aagagagga  ggctgaaga  ggccttgtc  atcagccat  2280
cagccccac  tacattgtc  aagagacgt  cctgtgacc  gtgacggac  tctcactgc  2340
gagcagtgg  cagagatac  ctggagtgc  gagctgagt  actgcatga  ttccgcagc  2400
ctggggtgg  tgacctagc  cacagcaaa  gaccttgat  tttaatgtt  caccgccgt  2460
ggagctgtc  catgcaagg  acagacagt  tttccttat  ccttgccag  cttctttta  2520
gatcaggtt  gcaaggtac  gaatcacag  acacgtggg  aaatatact  aggaaaggg  2580
ggcttttga  taagtgacc  gggttcttt  gggtgaata  gaacatttc  tacaactcc  2640
cttgagcaa  tttggcagg  ttgaccagc  ccagcattt  gcatgaagt  ctcagccct  2700
tggtgattc  ctcactctc  tgtcaacct  ggttatctc  agccagtgt  ggcctgtgg  2760
cttcaggtt  tctgtaaga  tcaagtctc  tctcattct  cctacctct  tttgtgaga  2820
ggaggcttt  gagcgcttg  gtctcagca  ttagtgcat  tacttggtg  atagaccct  2880
gctctcttc  ggtggtaca  gagagacag  tacatgaga  aggtcacca  gacctctta  2940
gcagtgtgc  atcctctaa  ctcctaagc  aggccaccc  ggtgtcatt  tgtcatctg  3000
gcaattctt  tttcctttg  gagtttcct  ctcatgcat  ttgttccta  ggaataaaa  3060
tagccatta  acctgaaaa  aaaaaaaaa  a  3091



<210> 597
<211> 634
<212> PRT
<213> Rattus norvegicus
<308> O70247
<400> 597

Met Thr Val Ala Ser Thr Ala Ala Pro Ser Tyr Thr Thr Ser Asp Thr 
  1               5                  10                  15
Asn Arg Val Ile Ser Thr Phe Ser Val Val Asp Tyr Val Val Phe Gly 
             20                  25                  30
Leu Leu Leu Val Leu Ser Leu Val Ile Gly Leu Tyr His Ala Cys Arg 
         35                  40                  45
Gly Trp Gly Arg His Thr Val Gly Glu Leu Leu Met Ala Asp Arg Lys 
     50                  55                  60
Met Gly Cys Leu Pro Val Ala Leu Ser Leu Leu Ala Thr Phe Gln Ser 
 65                  70                  75                  80
Ala Val Ala Ile Leu Gly Gly Pro Ala Glu Ile Tyr Arg Phe Gly Thr 
                 85                  90                  95
Gln Tyr Trp Phe Leu Gly Cys Ser Tyr Phe Leu Gly Leu Leu Ile Pro 
             100                105                110
Ala His Ile Phe Ile Pro Val Phe Tyr Arg Leu His Leu Thr Ser Ala 
         115                120                125
Tyr Glu Tyr Leu Glu Leu Arg Phe Asn Lys Ala Val Arg Ile Cys Gly 
     130                135                140
Thr Val Thr Phe Ile Phe Gln Met Val Val Tyr Met Gly Val Ala Leu 
 145                150                155                160
Tyr Ala Pro Ser Leu Ala Leu Asn Ala Val Thr Gly Phe Asp Leu Trp 
                 165                170                175
Leu Ser Val Leu Ala Leu Gly Ile Val Cys Asn Ile Tyr Thr Ala Leu 
             180                185                190
Gly Gly Leu Lys Ala Val Ile Trp Thr Asp Val Phe Gln Thr Leu Ile 
         195                200                205
Met Phe Leu Gly Gln Leu Val Val Ile Ile Val Gly Ala Ala Lys Val 
     210                215                220
Gly Gly Leu Gly His Val Trp Ala Val Ala Ser Gln His Gly Leu Ile 
 225                230                235                240
Ser Gly Ile Glu Leu Asp Pro Asp Pro Phe Val Arg His Thr Phe Trp 
                 245                250                255
Thr Leu Ala Phe Gly Gly Val Phe Met Met Leu Ser Leu Tyr Gly Val 
             260                265                270
Asn Gln Ala Gln Val Gln Arg Tyr Leu Ser Ser His Ser Glu Lys Ala 
         275                280                285
Ala Val Leu Ser Cys Tyr Ala Val Phe Pro Cys Gln Gln Val Ala Leu 
     290                295                300
Cys Met Ser Cys Leu Ile Gly Leu Val Met Phe Ala Tyr Tyr Lys Lys 
 305                310                315                320
Tyr Ser Met Ser Pro Gln Gln Glu Gln Ala Ala Pro Asp Gln Leu Val 
                 325                330                335
Leu Tyr Phe Val Met Asp Leu Leu Lys Asp Met Pro Gly Leu Pro Gly 
             340                345                350
Leu Phe Val Ala Cys Leu Phe Ser Gly Ser Leu Ser Thr Ile Ser Ser 
         355                360                365
Ala Phe Asn Ser Leu Ala Thr Val Thr Met Glu Asp Leu Ile Gln Pro 
     370                375                380
Trp Phe Pro Gln Leu Thr Glu Thr Arg Ala Ile Met Leu Ser Arg Ser 
 385                390                395                400
Leu Ala Phe Ala Tyr Gly Leu Val Cys Leu Gly Met Ala Tyr Val Ser 
                 405                410                415
Ser His Leu Gly Ser Val Leu Gln Ala Ala Leu Ser Ile Phe Gly Met 
             420                425                430
Val Gly Gly Pro Leu Leu Gly Leu Phe Cys Leu Gly Met Phe Phe Pro 
         435                440                445
Cys Ala Asn Pro Leu Gly Ala Ile Val Gly Leu Leu Thr Gly Leu Thr 
     450                455                460
Met Ala Phe Trp Ile Gly Ile Gly Ser Ile Val Ser Arg Met Ser Ser 
 465                470                475                480
Ala Ala Ala Ser Pro Pro Leu Asn Gly Ser Ser Ser Phe Leu Pro Ser 
                 485                490                495
Asn Leu Thr Val Ala Thr Val Thr Thr Leu Met Pro Ser Thr Leu Ser 
             500                505                510
Lys Pro Thr Gly Leu Gln Gln Phe Tyr Ser Leu Ser Tyr Leu Trp Tyr 
         515                520                525
Ser Ala His Asn Ser Thr Thr Val Ile Ala Val Gly Leu Ile Val Ser 
     530                535                540
Leu Leu Thr Gly Gly Met Arg Gly Arg Ser Leu Asn Pro Gly Thr Ile 
 545                550                555                560
Tyr Pro Val Leu Pro Lys Leu Leu Ala Leu Leu Pro Leu Ser Cys Gln 
                 565                570                575
Lys Arg Leu Cys Trp Arg Ser His Asn Gln Asp Ile Pro Val Val Thr 
             580                585                590
Asn Leu Phe Pro Glu Lys Met Gly Asn Gly Ala Leu Gln Asp Ser Arg 
         595                600                605
Asp Lys Glu Arg Met Ala Glu Asp Gly Leu Val His Gln Pro Cys Ser 
     610                615                620
Pro Thr Tyr Ile Val Gln Glu Thr Ser Leu 
 625                630



<210> 598
<211> 2310
<212> DNA
<213> Homo sapiens
<308> AL096737
<400> 598

gtcacatag  agtgaggac  tggtgggag  aagctgggg  gtgatgtaa  atgcctttt  60
tttccagag  gacagaggt  gtagtttgg  tgggcaggg  gccttgctt  accccattg  120
ttgtgttaa  tcacacctt  ttgtttcct  tcctgtcct  ttcccccag  ctttggcta  180
gggctgctt  gtctaggaa  ggcctatat  tcctcccag  tgggacctg  gctgcaggc  240
gcaatcagc  tctttggca  ggttggggg  ccgctgctg  gactcttct  ccttggaat  300
ttctttcca  gtgctaacc  tcctgtgag  gatgcatct  gatccacag  catgtgtag  360
aggatggac  tgggggttg  cagggctgt  accaggaga  ctgaggact  ccgtgaggg  420
tggcaggac  ggccttgtg  caggcctgc  ctgtgtctc  gcagggtgc  gttgtgggc  480
tgttggctg  gctcgtcat  gccttctgg  ttggcatcg  gagcatcgt  accagcatg  540
gcttcagca  gccaccctc  ccctctaat  ggtccagct  ctccctgcc  accaatcta  600
ccgttgcca  tgtgaccac  ctgatgccc  tgactacct  ctccaagta  ggcagggct  660
gctatcttc  tgttttctc  aagtcctcc  ttgagggct  tcacagggg  cttgctaag  720
gatgggcca  cagaggccc  agggaaatg  tgggtattg  gtcccaaga  cctgggacc  780
tgcgggcaa  tagagattg  tgcccaagg  atgccctgc  aacgaattg  taattgttc  840
cacctctgc  cttcccagg  ccacagggc  gcagcggtt  tattccttg  cttacttat  900
gtacagtgc  cacaactcc  ccacagtga  tgtggtggg  ctgattgtc  gtctactca  960
tggtaaggg  gtgggattg  ggtgcagat  agcaccgag  gttaacaga  ggccctaag  1020
gactctagg  agaaaggct  ctgccctct  agctcttgg  tgtccgtag  tgtcaggct  1080
ttctgctgg  atgtaggag  tgggtgggg  ctggggtct  tgggggcca  gggaggaca  1140
ggggcccgc  gctgtggat  gttccaccc  gagactcag  agcacattt  cattcaggg  1200
gaatgcgag  ccggtccct  aaccctgca  ccatttacc  agtgttgcc  aagctcctg  1260
ccctccttc  gttgtcctg  cagaagcgg  tccactgca  gagctacgg  caggaccac  1320
tcgacactg  cctgtttcc  gagaagccg  ggaatggtg  gctggggga  agcagagac  1380
aggaggcca  ggccctgga  ggcacagcc  atcagggga  cagctccac  tgcatcctc  1440
aggagacct  cctgtgatg  tgactcagg  ccccgcctc  gtcctcact  tgccaggcc  1500
tagccagag  ccaccctgt  gtacaggga  gagtcttgg  gtgttctgc  gggacaggc  1560
tggatgatc  agctcatac  aaaggacct  gttctgaga  gttcttgcc  gcaggagaa  1620
ctgtcacat  tcaagcatg  gaggcaccg  ttttctcgt  gcttgccaa  ctgtttttt  1680
aaggatcag  ctcgtaggg  gcaggatca  gccagaaat  gggatggaa  tgcatcctc  1740
gggaaaaag  taatggctt  tgattcaac  tagccatag  cctttgaag  aagtggcta  1800
aaacagcac  ctggttata  ttgccccag  gcctgattc  ggactgact  tccaccata  1860
aactggaag  tgcttcccc  gtagtcccc  tttcagtac  agttctgcc  gccacagtg  1920
gcccctatt  ttactttca  attgtctgt  acactcaag  ccctctcat  tttatctgt  1980
tacctccat  ctgaagagg  aggttttgg  gtccctggt  ctctgggaa  agaagatcc  2040
tttgtcttt  tgtagagca  gcacgtttt  cacctcact  tctccatcc  ccacctctg  2100
gatggacac  taagagacg  ggcaaatgt  gatccaaga  accagggcc  tgaccaggt  2160
cactgtgga  cagccatct  tctacctga  tcctgagcc  ggctgccgt  gtgtcattt  2220
tgtcatccg  gctctgttt  cttttggag  ttcttctcc  cattatctt  gttcctggg  2280
aataaaaac  accattgga  ctagaaaaaa  2310



<210> 599
<211> 635
<212> PRT
<213> Homo sapiens
<308> Q9Y289
<400> 599

Met Ser Val Gly Val Ser Thr Ser Ala Pro Leu Ser Pro Thr Ser Gly 
  1               5                  10                  15
Thr Ser Val Gly Met Ser Thr Phe Ser Ile Met Asp Tyr Val Val Phe 
             20                  25                  30
Val Leu Leu Leu Val Leu Ser Leu Ala Ile Gly Leu Tyr His Ala Cys 
         35                  40                  45
Arg Gly Trp Gly Arg His Thr Val Gly Glu Leu Leu Met Ala Asp Arg 
     50                  55                  60
Lys Met Gly Cys Leu Pro Val Ala Leu Ser Leu Leu Ala Thr Phe Gln 
 65                  70                  75                  80
Ser Ala Val Ala Ile Leu Gly Val Pro Ser Glu Ile Tyr Arg Phe Gly 
                 85                  90                  95
Thr Gln Tyr Trp Phe Leu Gly Cys Cys Tyr Phe Leu Gly Leu Leu Ile 
             100                105                110
Pro Ala His Ile Phe Ile Pro Val Phe Tyr Arg Leu His Leu Thr Ser 
         115                120                125
Ala Tyr Glu Tyr Leu Glu Leu Arg Phe Asn Lys Thr Val Arg Val Cys 
     130                135                140
Gly Thr Val Thr Phe Ile Phe Gln Met Val Ile Tyr Met Gly Val Val 
 145                150                155                160
Leu Tyr Ala Pro Ser Leu Ala Leu Asn Ala Val Thr Gly Phe Asp Leu 
                 165                170                175
Trp Leu Ser Val Leu Ala Leu Gly Ile Val Cys Thr Val Tyr Thr Ala 
             180                185                190
Leu Gly Gly Leu Lys Ala Val Ile Trp Thr Asp Val Phe Gln Thr Leu 
         195                200                205
Val Met Phe Leu Gly Gln Leu Ala Val Ile Ile Val Gly Ser Ala Lys 
     210                215                220
Val Gly Gly Leu Gly Arg Val Trp Ala Val Ala Ser Gln His Gly Arg 
 225                230                235                240
Ile Ser Gly Phe Glu Leu Asp Pro Asp Pro Phe Val Arg His Thr Phe 
                 245                250                255
Trp Thr Leu Ala Phe Gly Gly Val Phe Met Met Leu Ser Leu Tyr Gly 
             260                265                270
Val Asn Gln Ala Gln Val Gln Arg Tyr Leu Ser Ser Arg Thr Glu Lys 
         275                280                285
Ala Ala Val Leu Ser Cys Tyr Ala Val Phe Pro Phe Gln Gln Val Ser 
     290                295                300
Leu Cys Val Gly Cys Leu Ile Gly Leu Val Met Phe Ala Tyr Tyr Gln 
 305                310                315                320
Glu Tyr Pro Met Ser Ile Gln Gln Ala Gln Ala Ala Pro Asp Gln Phe 
                 325                330                335
Val Leu Tyr Phe Val Met Asp Leu Leu Lys Gly Leu Pro Gly Leu Pro 
             340                345                350
Gly Leu Phe Ile Ala Cys Leu Phe Ser Gly Ser Leu Ser Thr Ile Ser 
         355                360                365
Ser Ala Phe Asn Ser Leu Ala Thr Val Thr Met Glu Asp Leu Ile Arg 
     370                375                380
Pro Trp Phe Pro Glu Phe Ser Glu Ala Arg Ala Ile Met Leu Ser Arg 
 385                390                395                400
Gly Leu Ala Phe Gly Tyr Gly Leu Leu Cys Leu Gly Met Ala Tyr Ile 
                 405                410                415
Ser Ser Gln Met Gly Pro Val Leu Gln Ala Ala Ile Ser Ile Phe Gly 
             420                425                430
Met Val Gly Gly Pro Leu Leu Gly Leu Phe Cys Leu Gly Met Phe Phe 
         435                440                445
Pro Cys Ala Asn Pro Pro Gly Ala Val Val Gly Leu Leu Ala Gly Leu 
     450                455                460
Val Met Ala Phe Trp Ile Gly Ile Gly Ser Ile Val Thr Ser Met Gly 
 465                470                475                480
Phe Ser Met Pro Pro Ser Pro Ser Asn Gly Ser Ser Phe Ser Leu Pro 
                 485                490                495
Thr Asn Leu Thr Val Ala Thr Val Thr Thr Leu Met Pro Leu Thr Thr 
             500                505                510
Phe Ser Lys Pro Thr Gly Leu Gln Arg Phe Tyr Ser Leu Ser Tyr Leu 
         515                520                525
Trp Tyr Ser Ala His Asn Ser Thr Thr Val Ile Val Val Gly Leu Ile 
     530                535                540
Val Ser Leu Leu Thr Gly Arg Met Arg Gly Arg Ser Leu Asn Pro Ala 
 545                550                555                560
Thr Ile Tyr Pro Val Leu Pro Lys Leu Leu Ser Leu Leu Pro Leu Ser 
                 565                570                575
Cys Gln Lys Arg Leu His Cys Arg Ser Tyr Gly Gln Asp His Leu Asp 
             580                585                590
Thr Gly Leu Phe Pro Glu Lys Pro Arg Asn Gly Val Leu Gly Asp Ser 
         595                600                605
Arg Asp Lys Glu Ala Met Ala Leu Asp Gly Thr Ala Tyr Gln Gly Ser 
     610                615                620
Ser Ser Thr Cys Ile Leu Gln Glu Thr Ser Leu 
 625                630                635



<210> 600
<211> 2304
<212> DNA
<213> Rattus norvegicus
<308> AF027571
<400> 600

ttgccatct  ctaatgacc  caaaagaaa  atactcatc  aaaataaaa  gctgaagcc  60
gaagttgaa  aaaaacagc  ggaggcttt  aaaagcatg  tggaggctg  agaatcagc  120
gccccggcc  gcatcttgg  agatgacaa  gaggaggaa  tagaaagcg  tgatcaaga  180
gaagaagcc  accctgaat  caagtttgg  aatgaactt  ctgccgatg  cttcagtca  240
aaggaagcg  ttgcaaaca  cgtcaagaa  ggcctggtc  ccgtagaag  tgaacaggc  300
tggatggca  cttataaat  cgtaggtgc  accacgaat  tccatccgt  cttgtccac  360
atgatcaac  atgcacagc  tgtgaagtt  caaggtttc  atgtggctg  agagcgcaa  420
attcattat  acatgtctt  ttttaacga  tcggttggc  ttggctact  gaagacgca  480
gcgattgag  ttgtaaatt  caataagcg  caaatgagc  gcatttacc  caagggagg  540
cgagttgat  ccagtaatt  catgcctca  attttctgg  acgctggtt  ccaaatggt  600
tcactgaac  atcaaaccc  agatttagc  atgcaattg  atcaaggaa  atttgagta  660
aacggatcc  gcggatacc  cctcaagcc  gacttcatg  gacggcctg  tcggacatt  720
gatcccttc  ctgaaaccc  tgtggacgg  gttattgca  ccacatgct  agtgcaggt  780
atatcaggg  agttcctgt  agataagaa  atcggcaca  acgtggaag  cgatatgta  840
gggctgccc  ccgacacca  acggaagga  ttccgaacc  gcatggtta  gaacaatgg  900
ctcaaccca  tttacaatg  agaatcgtt  gtgtttcgg  aggtgatcc  gcctgacct  960
gctgtcctg  gaatcgctg  gtacgacga  aacaacaag  tcattggcc  gaggatcct  1020
cctctggat  gcctccagg  aggctaccg  cacatctcc  tgagaaatg  gggaaacaa  1080
ccgttatca  tgccaacaa  tttctgcaa  atcgttctt  aaacatatg  gcctgatgg  1140
tttggagat  ttgtggatg  tctatccga  ccaaagaaa  tcctttcaa  caccgagaa  1200
agagcagac  aaatgagag  aatgggcat  gaaactagt  acatagcag  tgtgcccag  1260
gacacttcc  aaaatgaca  gaaaggcaa  gccaaccca  ccaaagcga  tgtaacccc  1320
cagagcagc  ctgagctca  accaaccac  acagctgcc  tgggatctg  ccaggaagc  1380
aagaaaggt  ttgaactta  ccctcaagt  aggatagaa  atttaaagc  aatgaaggc  1440
tacttgaag  atttaaaga  acaacaaaa  gagttaaac  ctttaaaga  gaaacacgc  1500
aaggagcac  gtaccatgc  gaagttaca  tgcacacaa  tggacaaaa  cgtggccca  1560
tatgacaag  agaagtcga  tcatgagaa  atcctagag  aggccatga  gaagaaggg  1620
ggaagtaat  gccttgaaa  aaaaaaaga  acagaaatt  agattcaga  cctgacatc  1680
gatcacaaa  ctaaggtca  ggagattgt  gcgcagcac  caaaggagt  ctcagaaat  1740
atcaacacg  acagcgccg  ggagcagga  atccgggac  tgcacatga  ccagcagtg  1800
gagctgctg  ggaagctgc  catcaacgt  catgagcag  agacccagc  gctgaaggt  1860
tcccatgac  gggaaagca  agagatgcg  gcccatcag  ctaagattt  tatggaaaa  1920
agcaaagcc  tcagtcaag  taaatctat  aagaataag  cagaacggg  gaggcgagt  1980
agggagttg  acagcagca  cactaagaa  tttctagaa  aaagaaaga  actggcaat  2040
aagcagtcg  aagaaatgg  tcagctgaa  aaggtccag  tggagcacc  agaattcct  2100
gagaaacag  atgagcagc  tttgaaatc  tgtcatgca  tgtcccaaa  acaaggcga  2160
ggagatgca  cagatggtg  aattggaag  cgagatgga  cgcagacca  caacagtag  2220
atgaaactc  agaatgcaa  ctgaagctg  aagaccata  aacaccaga  gatcacgcc  2280
agcttcaga  gacagactc  atgg  2304



<210> 601
<211> 1175
<212> PRT
<213> Rattus norvegicus
<308> Q9QW07
<400> 601

Met Ala Lys Pro Tyr Glu Phe Asn Trp Gln Lys Glu Val Pro Ser Phe 
  1               5                  10                  15
Leu Gln Glu Gly Ala Val Phe Asp Arg Tyr Glu Glu Glu Ser Phe Val 
             20                  25                  30
Phe Glu Pro Asn Cys Leu Phe Lys Val Asp Glu Phe Gly Phe Phe Leu 
         35                  40                  45
Thr Trp Lys Ser Glu Gly Lys Glu Gly Gln Val Leu Glu Cys Ser Leu 
     50                  55                  60
Ile Asn Ser Ile Arg Leu Ala Ala Ile Pro Lys Asp Pro Lys Ile Leu 
 65                  70                  75                  80
Ala Ala Leu Glu Ser Val Gly Lys Ser Glu Asn Asp Leu Glu Gly Arg 
                 85                  90                  95
Ile Leu Cys Val Cys Ser Gly Thr Asp Leu Val Asn Ile Gly Phe Thr 
             100                105                110
Tyr Met Val Ala Glu Asn Pro Glu Ile Thr Lys Gln Trp Val Glu Gly 
         115                120                125
Leu Arg Ser Ile Ile His Asn Phe Arg Ala Asn Asn Val Ser Pro Met 
     130                135                140
Thr Cys Leu Lys Lys His Trp Met Lys Leu Ala Phe Leu Thr Asn Thr 
 145                150                155                160
Ser Gly Lys Ile Pro Val Arg Ser Ile Thr Arg Thr Phe Ala Ser Gly 
                 165                170                175
Lys Thr Glu Lys Val Ile Phe Gln Ala Leu Lys Glu Leu Gly Leu Pro 
             180                185                190
Ser Gly Lys Asn Asp Glu Ile Glu Pro Ala Ala Phe Thr Tyr Glu Lys 
         195                200                205
Phe Tyr Glu Leu Thr Gln Lys Ile Cys Pro Arg Thr Asp Ile Glu Asp 
     210                215                220
Leu Phe Lys Lys Ile Asn Gly Asp Lys Thr Asp Tyr Leu Thr Val Asp 
 225                230                235                240
Gln Leu Val Ser Phe Leu Asn Glu His Gln Arg Asp Pro Arg Leu Asn 
                 245                250                255
Glu Ile Leu Phe Pro Phe Tyr Asp Ala Lys Arg Ala Met Gln Ile Ile 
             260                265                270
Glu Met Tyr Glu Pro Asp Glu Glu Leu Lys Lys Lys Gly Leu Ile Ser 
         275                280                285
Ser Asp Gly Phe Cys Arg Tyr Leu Met Ser Asp Glu Asn Ala Pro Val 
     290                295                300
Phe Leu Asp Arg Leu Glu Leu Tyr Gln Glu Met Asp His Pro Leu Ala 
 305                310                315                320
His Tyr Phe Ile Ser Ser Ser His Asn Thr Tyr Leu Thr Gly Arg Gln 
                 325                330                335
Phe Gly Gly Lys Ser Ser Val Glu Met Tyr Arg Gln Val Leu Leu Ala 
             340                345                350
Gly Cys Arg Cys Val Glu Leu Asp Cys Trp Asp Gly Lys Gly Glu Asp 
         355                360                365
Gln Glu Pro Ile Ile Thr His Gly Lys Ala Met Cys Thr Asp Ile Leu 
     370                375                380
Phe Lys Asp Val Ile Gln Ala Ile Lys Glu Thr Ala Phe Val Thr Ser 
 385                390                395                400
Glu Tyr Pro Val Ile Leu Ser Phe Glu Asn His Cys Ser Lys Tyr Gln 
                 405                410                415
Gln Tyr Gln Met Ser Lys Tyr Cys Glu Asp Leu Phe Gly Asp Leu Leu 
             420                425                430
Leu Lys Gln Ala Leu Glu Ser His Pro Leu Glu Pro Gly Arg Leu Leu 
         435                440                445
Pro Ser Pro Asn Asp Leu Lys Arg Lys Ile Leu Ile Lys Asn Lys Arg 
     450                455                460
Leu Lys Pro Glu Val Glu Lys Lys Gln Leu Glu Ala Leu Lys Ser Met 
 465                470                475                480
Met Glu Ala Gly Glu Ser Ala Ala Pro Ala Ser Ile Leu Glu Asp Asp 
                 485                490                495
Asn Glu Glu Glu Ile Glu Ser Ala Asp Gln Glu Glu Glu Ala His Pro 
             500                505                510
Glu Tyr Lys Phe Gly Asn Glu Leu Ser Ala Asp Asp Phe Ser His Lys 
         515                520                525
Glu Ala Val Ala Asn Ser Val Lys Lys Gly Leu Val Thr Val Glu Asp 
     530                535                540
Glu Gln Ala Trp Met Ala Ser Tyr Lys Tyr Val Gly Ala Thr Thr Asn 
 545                550                555                560
Ile His Pro Tyr Leu Ser Thr Met Ile Asn Tyr Ala Gln Pro Val Lys 
                 565                570                575
Phe Gln Gly Phe His Val Ala Glu Glu Arg Asn Ile His Tyr Asn Met 
             580                585                590
Ser Ser Phe Asn Glu Ser Val Gly Leu Gly Tyr Leu Lys Thr His Ala 
         595                600                605
Ile Glu Phe Val Asn Tyr Asn Lys Arg Gln Met Ser Arg Ile Tyr Pro 
     610                615                620
Lys Gly Gly Arg Val Asp Ser Ser Asn Tyr Met Pro Gln Ile Phe Trp 
 625                630                635                640
Asn Ala Gly Cys Gln Met Val Ser Leu Asn Tyr Gln Thr Pro Asp Leu 
                 645                650                655
Ala Met Gln Leu Asn Gln Gly Lys Phe Glu Tyr Asn Gly Ser Cys Gly 
             660                665                670
Tyr Leu Leu Lys Pro Asp Phe Met Arg Arg Pro Asp Arg Thr Phe Asp 
         675                680                685
Pro Phe Ser Glu Thr Pro Val Asp Gly Val Ile Ala Ala Thr Cys Ser 
     690                695                700
Val Gln Val Ile Ser Gly Gln Phe Leu Ser Asp Lys Lys Ile Gly Thr 
 705                710                715                720
Tyr Val Glu Val Asp Met Tyr Gly Leu Pro Thr Asp Thr Ile Arg Lys 
                 725                730                735
Glu Phe Arg Thr Arg Met Val Met Asn Asn Gly Leu Asn Pro Val Tyr 
             740                745                750
Asn Glu Glu Ser Phe Val Phe Arg Lys Val Ile Leu Pro Asp Leu Ala 
         755                760                765
Val Leu Arg Ile Ala Val Tyr Asp Asp Asn Asn Lys Leu Ile Gly Gln 
     770                775                780
Arg Ile Leu Pro Leu Asp Gly Leu Gln Ala Gly Tyr Arg His Ile Ser 
 785                790                795                800
Leu Arg Asn Glu Gly Asn Lys Pro Leu Ser Leu Pro Thr Ile Phe Cys 
                 805                810                815
Asn Ile Val Leu Lys Thr Tyr Val Pro Asp Gly Phe Gly Asp Ile Val 
             820                825                830
Asp Ala Leu Ser Asp Pro Lys Lys Phe Leu Ser Ile Thr Glu Lys Arg 
         835                840                845
Ala Asp Gln Leu Arg Ala Met Gly Ile Glu Thr Ser Asp Ile Ala Asp 
     850                855                860
Val Pro Ser Asp Thr Ser Lys Asn Asp Lys Lys Gly Lys Ala Asn Pro 
 865                870                875                880
Ala Lys Ala Asn Val Thr Pro Gln Ser Ser Ser Glu Leu Arg Pro Thr 
                 885                890                895
Thr Thr Ala Ala Leu Gly Ser Gly Gln Glu Ala Lys Lys Gly Ile Glu 
             900                905                910
Leu Ile Pro Gln Val Arg Ile Glu Asp Leu Lys Gln Met Lys Ala Tyr 
         915                920                925
Leu Lys His Leu Lys Lys Gln Gln Lys Glu Leu Asn Ser Leu Lys Lys 
     930                935                940
Lys His Ala Lys Glu His Ser Thr Met Gln Lys Leu His Cys Thr Gln 
 945                950                955                960
Val Asp Lys Ile Val Ala Gln Tyr Asp Lys Glu Lys Ser Thr His Glu 
                 965                970                975
Lys Ile Leu Glu Lys Ala Met Lys Lys Lys Gly Gly Ser Asn Cys Leu 
             980                985                990
Glu Ile Lys Lys Glu Thr Glu Ile Lys Ile Gln Thr Leu Thr Ser Asp 
         995                1000                1005
His Lys Ser Lys Val Lys Glu Ile Val Ala Gln His Thr Lys Glu Trp 
     1010                1015                1020
Ser Glu Met Ile Asn Thr His Ser Ala Glu Glu Gln Glu Ile Arg Asp 
 1025                1030                1035                1040
Leu His Leu Ser Gln Gln Cys Glu Leu Leu Arg Lys Leu Leu Ile Asn 
                 1045                1050                1055
Ala His Glu Gln Gln Thr Gln Gln Leu Lys Leu Ser His Asp Arg Glu 
             1060                1065                1070
Ser Lys Glu Met Arg Ala His Gln Ala Lys Ile Ser Met Glu Asn Ser 
         1075                1080                1085
Lys Ala Ile Ser Gln Asp Lys Ser Ile Lys Asn Lys Ala Glu Arg Glu 
     1090                1095                1100
Arg Arg Val Arg Glu Leu Asn Ser Ser Asn Thr Lys Lys Phe Leu Glu 
 1105                1110                1115                1120
Glu Arg Lys Arg Leu Ala Met Lys Gln Ser Lys Glu Met Asp Gln Leu 
                 1125                1130                1135
Lys Lys Val Gln Leu Glu His Leu Glu Phe Leu Glu Lys Gln Asn Glu 
             1140                1145                1150
Gln Ala Lys Glu Met Gln Gln Met Val Lys Leu Glu Ala Glu Met Asp 
         1155                1160                1165
Arg Arg Pro Ala Thr Val Val 
     1170                1175



<210> 602
<211> 3707
<212> DNA
<213> Homo sapiens
<308> L41349
<400> 602

gtgtgtccc  ccagtgccg  ttgcccctt  ttctcccaa  caccagggg  acccctgtc  60
tagattcaa  ttgcatcac  agactaaca  ctctgggaa  agaggacac  gaggactag  120
ttgggaaat  aaaaacatc  gcaatgaga  gtaatttta  tctcctctt  cttttaccc  180
agtctcact  tccatagta  gacctggat  tttgcatca  agaaaacat  atgaacaat  240
actggaatg  gtgtttctt  cttttctgc  ctagtatta  tagaacatt  gcatcggga  300
aaacagaaa  ggtgatctt  caagcactc  aggagttag  tcttcccag  ggaaagaat  360
atgaaattg  gcccacagc  ttttcttat  aaaagttct  tgaactgac  caaaagatt  420
gtcctcgga  agatataga  gatcttttc  aaaaaatca  tggagacaa  actgattat  480
taacggtag  ccaattagt  agctttcta  atgaacatc  acgagatcc  cgattgaat  540
aaattttat  tccatttta  gatgccaaa  gggcaatgc  gatcattga  atgtatgaa  600
ctgatgaag  tttgaagaa  aaaggcctt  tatcaagtg  tgggttttg  agatatctg  660
tgtcagatg  aaacgcccc  gtcttccta  atcgtttag  actttacca  gaaatggac  720
atcctctgg  tcactactt  atcagttct  cccataaca  ttatctcac  ggcagacag  780
tcggcggga  gtcttcggt  gaaatgtac  gacaggttc  cctggctgg  tgcagatgt  840
ttgaacttg  ctgctggga  ggaaaaggt  aggaccaag  accaataat  actcatgga  900
aagcaatgt  tacagatat  ctttttaag  atgtaattc  agccatcaa  gaaactgca  960
ttgtcacat  agaatatcc  gtaattctc  cctttgaaa  tcactgcag  aaatatcaa  1020
agtacaaga  gtccaaata  tgcgaagat  tatttgggg  tctcctgtt  aaacaagca  1080
ttgaatcac  tccactgga  ccaggcaga  ctttgccat  ccccaatga  ctcaaaaga  1140
aaatactca  aaaaaacaa  cggctgaaa  ctgaagttg  aaaaaaaca  ctggaagct  1200
tgagaagca  gatggaagc  ggagaatct  cctccccag  aaacatctt  gaggacgat  1260
atgaagagg  gatcgaaag  gctgaccaa  aggaggaag  tcaccccga  ttcaaattt  1320
gaaatgaac  ttctgctga  gacttgggt  acaaggaag  tgttgcaaa  agcgtcaag  1380
agggcctgg  cactgtaga  gatgagcag  cgtggatgg  atcttataa  tatgtaggt  1440
ctaccacta  tatccatcc  tatttgtcc  caatgatca  ctatgccca  cctgtaaag  1500
ttcaaggtt  ccatgtggc  gaagaacgc  atattcatt  taacatgtc  tcttttaat  1560
aatcagtcg  tcttggcta  ttgaagaca  atgcaattg  atttgtcaa  tataacaaa  1620
ggcaaatga  tcgcattta  cccaaggga  gccgagtcg  ttccagtaa  tacatgcct  1680
agattttct  gaacgctgg  tgccagatg  tttcactga  ctatcaaac  ccagattta  1740
cgatgcaat  gaatcaggg  aaatttgag  ataatggat  gtgcgggta  cttctcaaa  1800
cagatttca  gaggcggcc  gatcgaaca  ttgacccct  ctctgaaac  cctgttgat  1860
gggttattg  agccacttg  tcagtgcag  ttatatcag  tcaattctt  tcagataag  1920
aaattggca  ctacgtaga  gtggatatg  atgggttgc  cactgacac  atacgtaag  1980
aattccgaa  tcgcatggt  atgaataat  gactcaatc  agtttacaa  gaagagtca  2040
ttgtatttc  gaaggtgat  ctgccggac  tggctgtct  gagaatagc  gtgtatgat  2100
ataacaaca  gctgattgg  cagaggatt  ctccgcttg  tggcctcca  gccggatat  2160
gacacattt  ccttcgaaa  gagggaaat  aaccattat  actaccaac  attttctgc  2220
atattgttc  taaaacata  gtgcctgat  gatttggag  tatcgtgga  gctttatca  2280
atccaaaga  atttctctc  attacagaa  agagagcag  ccaaatgag  gctatgggc  2340
ttgagacta  tgacatagc  gacgtgccc  gtgacactt  caaaaatga  aagaaagga  2400
aggccaaca  cgccaaagc  aatgtgacc  ctcagagta  ctctgagct  agaccaacc  2460
ccacggctg  cctgccgtc  ggtgtggaa  ccaagaaag  tattgaact  atccctcaa  2520
taaggatag  agacttaaa  cagatgaag  cttacttga  gcatttaaa  aaacagcag  2580
aggagctaa  ttctttaaa  aagaaacat  caaaggaac  cagtaccat  cagaagtta  2640
actgcacgc  agttgacaa  attgtggca  agtatgaca  agagaagtc  actcatgag  2700
aaatcctag  gaaggcaat  aagaagaaa  ggggaagta  ttgtcttga  atgaagaaa  2760
aaacagaaa  taaaattca  acgctgaca  cagatcaca  atctaaggt  aaggagatt  2820
tagcacagc  cacaaagga  tggtcagaa  tgatcaata  tcacagtgc  gaggagcaa  2880
aaatccgag  cctgcacct  agccagcag  gtgagctgc  gaaaaagct  ctcatcaat  2940
cccacgagc  gcaaaccca  cagctgaaa  tgtcccatg  cagggaaag  aaggaaatg  3000
gagcacacc  ggctaagat  tctatggaa  atagcaaag  catcagcca  gataaatct  3060
tcaagaata  agcagaacg  gaaaggcga  tcagggagt  aaacagcag  aacactaaa  3120
agtttctgg  agaaagaaa  agacttgcc  tgaagcagt  caaagaaat  gatcagttg  3180
aaaaagtcc  gcttgaaca  ctagaattc  tagagaaac  gaatgagca  gcgaaggag  3240
tgcagcaga  ggtgaaatt  gaagccgag  tggaccgca  accagcaac  gtagtatga  3300
actccaaaa  gcaaactga  gcagcaaac  cacaaagca  caaaagact  actcacaaa  3360
cttctgaac  caaactcca  ggatgaaag  tgtttattt  gtttccttt  tgtgtaaac  3420
agatgatat  tgaaaccag  gagacttgg  atgtctgac  gacttctat  taacagctt  3480
agtattgca  ttccttggc  aaacaaaaa  agctacaaa  ccacaaaaa  ttactattc  3540
agtaaggca  agtccaacc  ttgataata  aacttaaac  tgtttgcta  aaaatacca  3600
cacaagtaa  tgagcttgg  gtgaacaac  cttcctttg  gatgcctta  gacatgttg  3660
aactgcagg  aaaacaaac  aaacagtgc  ttagcaatt  catagca  3707



<210> 603
<211> 1175
<212> PRT
<213> Homo sapiens
<308> Q15147
<400> 603

Met Ala Lys Pro Tyr Glu Phe Asn Trp Gln Lys Glu Val Pro Ser Phe 
  1               5                  10                  15
Leu Gln Glu Gly Ala Val Phe Asp Arg Tyr Glu Glu Glu Ser Phe Val 
             20                  25                  30
Phe Glu Pro Asn Cys Leu Phe Lys Val Asp Glu Phe Gly Phe Phe Leu 
         35                  40                  45
Thr Trp Arg Ser Glu Gly Lys Glu Gly Gln Val Leu Glu Cys Ser Leu 
     50                  55                  60
Ile Asn Ser Ile Arg Ser Gly Ala Ile Pro Lys Asp Pro Lys Ile Leu 
 65                  70                  75                  80
Ala Ala Leu Glu Ala Val Gly Lys Ser Glu Asn Asp Leu Glu Gly Arg 
                 85                  90                  95
Ile Val Cys Val Cys Ser Gly Thr Asp Leu Val Asn Ile Ser Phe Thr 
             100                105                110
Tyr Met Val Ala Glu Asn Pro Glu Val Thr Lys Gln Trp Val Glu Gly 
         115                120                125
Leu Arg Ser Ile Ile His Asn Phe Arg Ala Asn Asn Val Ser Pro Met 
     130                135                140
Thr Cys Leu Lys Lys His Trp Met Lys Leu Ala Phe Met Thr Asn Thr 
 145                150                155                160
Asn Gly Lys Ile Pro Val Arg Ser Ile Thr Arg Thr Phe Ala Ser Gly 
                 165                170                175
Lys Thr Glu Lys Val Ile Phe Gln Ala Leu Lys Glu Leu Gly Leu Pro 
             180                185                190
Ser Gly Lys Asn Asp Glu Ile Glu Pro Thr Ala Phe Ser Tyr Glu Lys 
         195                200                205
Phe Tyr Glu Leu Thr Gln Lys Ile Cys Pro Arg Thr Asp Ile Glu Asp 
     210                215                220
Leu Phe Lys Lys Ile Asn Gly Asp Lys Thr Asp Tyr Leu Thr Val Asp 
 225                230                235                240
Gln Leu Val Ser Phe Leu Asn Glu His Gln Arg Asp Pro Arg Leu Asn 
                 245                250                255
Glu Ile Leu Phe Pro Phe Tyr Asp Ala Lys Arg Ala Met Gln Ile Ile 
             260                265                270
Glu Met Tyr Glu Pro Asp Glu Asp Leu Lys Lys Lys Gly Leu Ile Ser 
         275                280                285
Ser Asp Gly Phe Cys Arg Tyr Leu Met Ser Asp Glu Asn Ala Pro Val 
     290                295                300
Phe Leu Asp Arg Leu Glu Leu Tyr Gln Glu Met Asp His Pro Leu Ala 
 305                310                315                320
His Tyr Phe Ile Ser Ser Ser His Asn Thr Tyr Leu Thr Gly Arg Gln 
                 325                330                335
Phe Gly Gly Lys Ser Ser Val Glu Met Tyr Arg Gln Val Leu Leu Ala 
             340                345                350
Gly Cys Arg Cys Val Glu Leu Asp Cys Trp Asp Gly Lys Gly Glu Asp 
         355                360                365
Gln Glu Pro Ile Ile Thr His Gly Lys Ala Met Cys Thr Asp Ile Leu 
     370                375                380
Phe Lys Asp Val Ile Gln Ala Ile Lys Glu Thr Ala Phe Val Thr Ser 
 385                390                395                400
Glu Tyr Pro Val Ile Leu Ser Phe Glu Asn His Cys Ser Lys Tyr Gln 
                 405                410                415
Gln Tyr Lys Met Ser Lys Tyr Cys Glu Asp Leu Phe Gly Asp Leu Leu 
             420                425                430
Leu Lys Gln Ala Leu Glu Ser His Pro Leu Glu Pro Gly Arg Ala Leu 
         435                440                445
Pro Ser Pro Asn Asp Leu Lys Arg Lys Ile Leu Ile Lys Asn Lys Arg 
     450                455                460
Leu Lys Pro Glu Val Glu Lys Lys Gln Leu Glu Ala Leu Arg Ser Met 
 465                470                475                480
Met Glu Ala Gly Glu Ser Ala Ser Pro Ala Asn Ile Leu Glu Asp Asp 
                 485                490                495
Asn Glu Glu Glu Ile Glu Ser Ala Asp Gln Glu Glu Glu Ala His Pro 
             500                505                510
Glu Phe Lys Phe Gly Asn Glu Leu Ser Ala Asp Asp Leu Gly His Lys 
         515                520                525
Glu Ala Val Ala Asn Ser Val Lys Lys Gly Leu Val Thr Val Glu Asp 
     530                535                540
Glu Gln Ala Trp Met Ala Ser Tyr Lys Tyr Val Gly Ala Thr Thr Asn 
 545                550                555                560
Ile His Pro Tyr Leu Ser Thr Met Ile Asn Tyr Ala Gln Pro Val Lys 
                 565                570                575
Phe Gln Gly Phe His Val Ala Glu Glu Arg Asn Ile His Tyr Asn Met 
             580                585                590
Ser Ser Phe Asn Glu Ser Val Gly Leu Gly Tyr Leu Lys Thr His Ala 
         595                600                605
Ile Glu Phe Val Asn Tyr Asn Lys Arg Gln Met Ser Arg Ile Tyr Pro 
     610                615                620
Lys Gly Gly Arg Val Asp Ser Ser Asn Tyr Met Pro Gln Ile Phe Trp 
 625                630                635                640
Asn Ala Gly Cys Gln Met Val Ser Leu Asn Tyr Gln Thr Pro Asp Leu 
                 645                650                655
Ala Met Gln Leu Asn Gln Gly Lys Phe Glu Tyr Asn Gly Ser Cys Gly 
             660                665                670
Tyr Leu Leu Lys Pro Asp Phe Met Arg Arg Pro Asp Arg Thr Phe Asp 
         675                680                685
Pro Phe Ser Glu Thr Pro Val Asp Gly Val Ile Ala Ala Thr Cys Ser 
     690                695                700
Val Gln Val Ile Ser Gly Gln Phe Leu Ser Asp Lys Lys Ile Gly Thr 
 705                710                715                720
Tyr Val Glu Val Asp Met Tyr Gly Leu Pro Thr Asp Thr Ile Arg Lys 
                 725                730                735
Glu Phe Arg Thr Arg Met Val Met Asn Asn Gly Leu Asn Pro Val Tyr 
             740                745                750
Asn Glu Glu Ser Phe Val Phe Arg Lys Val Ile Leu Pro Asp Leu Ala 
         755                760                765
Val Leu Arg Ile Ala Val Tyr Asp Asp Asn Asn Lys Leu Ile Gly Gln 
     770                775                780
Arg Ile Leu Pro Leu Asp Gly Leu Gln Ala Gly Tyr Arg His Ile Ser 
 785                790                795                800
Leu Arg Asn Glu Gly Asn Lys Pro Leu Ser Leu Pro Thr Ile Phe Cys 
                 805                810                815
Asn Ile Val Leu Lys Thr Tyr Val Pro Asp Gly Phe Gly Asp Ile Val 
             820                825                830
Asp Ala Leu Ser Asp Pro Lys Lys Phe Leu Ser Ile Thr Glu Lys Arg 
         835                840                845
Ala Asp Gln Met Arg Ala Met Gly Ile Glu Thr Ser Asp Ile Ala Asp 
     850                855                860
Val Pro Ser Asp Thr Ser Lys Asn Asp Lys Lys Gly Lys Ala Asn Thr 
 865                870                875                880
Ala Lys Ala Asn Val Thr Pro Gln Ser Ser Ser Glu Leu Arg Pro Thr 
                 885                890                895
Thr Thr Ala Ala Leu Ala Ser Gly Val Glu Ala Lys Lys Gly Ile Glu 
             900                905                910
Leu Ile Pro Gln Val Arg Ile Glu Asp Leu Lys Gln Met Lys Ala Tyr 
         915                920                925
Leu Lys His Leu Lys Lys Gln Gln Lys Glu Leu Asn Ser Leu Lys Lys 
     930                935                940
Lys His Ala Lys Glu His Ser Thr Met Gln Lys Leu His Cys Thr Gln 
 945                950                955                960
Val Asp Lys Ile Val Ala Gln Tyr Asp Lys Glu Lys Ser Thr His Glu 
                 965                970                975
Lys Ile Leu Glu Lys Ala Met Lys Lys Lys Gly Gly Ser Asn Cys Leu 
             980                985                990
Glu Met Lys Lys Glu Thr Glu Ile Lys Ile Gln Thr Leu Thr Ser Asp 
         995                1000                1005
His Lys Ser Lys Val Lys Glu Ile Val Ala Gln His Thr Lys Glu Trp 
     1010                1015                1020
Ser Glu Met Ile Asn Thr His Ser Ala Glu Glu Gln Glu Ile Arg Asp 
 1025                1030                1035                1040
Leu His Leu Ser Gln Gln Cys Glu Leu Leu Lys Lys Leu Leu Ile Asn 
                 1045                1050                1055
Ala His Glu Gln Gln Thr Gln Gln Leu Lys Leu Ser His Asp Arg Glu 
             1060                1065                1070
Ser Lys Glu Met Arg Ala His Gln Ala Lys Ile Ser Met Glu Asn Ser 
         1075                1080                1085
Lys Ala Ile Ser Gln Asp Lys Ser Ile Lys Asn Lys Ala Glu Arg Glu 
     1090                1095                1100
Arg Arg Val Arg Glu Leu Asn Ser Ser Asn Thr Lys Lys Phe Leu Glu 
 1105                1110                1115                1120
Glu Arg Lys Arg Leu Ala Met Lys Gln Ser Lys Glu Met Asp Gln Leu 
                 1125                1130                1135
Lys Lys Val Gln Leu Glu His Leu Glu Phe Leu Glu Lys Gln Asn Glu 
             1140                1145                1150
Gln Ala Lys Glu Met Gln Gln Met Val Lys Leu Glu Ala Glu Met Asp 
         1155                1160                1165
Arg Arg Pro Ala Thr Val Val 
     1170                1175



<210> 604
<211> 4969
<212> DNA
<213> Rattus norvegicus
<308> AF029240
<400> 604

aagcttaca  agaccctac  acaagactt  gtgaaaccg  gtgcccaag  gcacaagtg  60
ggttccgtg  ggtttagtg  ggtttacac  acaggaggt  gtgtaaaca  ctcctgctg  120
tttctcttt  ataaagaca  aagtgatac  gtctcgcct  tcgttcctg  tggacgcag  180
cgtctgtag  agccaatca  cagcacaga  gttccaaag  acgagtcaa  agaaacaca  240
cccacattc  tgtttttca  agtccctgg  cgtgaggat  ttacctcct  cctatttgc  300
ccaactact  gcaggcacc  tggtcctga  ccagactag  aagtgcggg  aggggtcgg  360
aaagaaaag  ctctgagag  tgaaagggg  tggggtgtg  ggccagggg  ggtggcggg  420
gggggcagc  ccctagggt  tgtcaccct  tcccagtcc  tcctctgcc  gcacctgag  480
tcctgagcc  agaggagct  agggtctca  tgcgcgccg  ccccaggct  acactcgct  540
cggtatttc  acaccgccc  gtcccggcc  ggcctcggg  agcccaggt  cattgtcgt  600
ggctacgtg  acgacacgc  gttcgtgcg  tatgacagc  atgtggaga  tccgaggat  660
gagccacgg  cgcggtgga  ggagcagga  gagccggca  attgggagc  ggagactcg  720
aaagccagg  acaccggga  gaacttcaa  gtgaatctg  ggaccctgc  ccgctacta  780
aatcagagt  acgacggtt  agttgactg  cggagggat  acaaacagg  tccctccat  840
ttccctgag  ctggcctgg  tcatcttga  cccggccgg  tcaaagtat  atccaaacg  900
ctacctaga  atcccagac  agaaagccc  ggcagagtt  tgcttaggt  tcggttgca  960
ttttgtttc  aaaaattct  gcatatcta  tgacagcgg  caagatggc  acgaggggg  1020
gctgaaccg  cgtttcccc  ttcagaatc  cacacgctg  agtggatgt  cggctgcga  1080
gtggggccc  atgggcacc  gctccgcgg  tattgtcag  aggcttatg  cggccggga  1140
tatatctcc  tgaacgagg  cctgcgctc  tggaccgcg  ctgacatgg  ctcacaggc  1200
tctaagatc  agtcagagg  agttggtga  gcccatcac  agagggcct  cctgcaagg  1260
ccttgcgtg  agtggctcc  cacatacct  catctggga  aggagacgc  gctgcgctc  1320
ggtgccctg  agacccctc  ttagttttc  tctgggggt  tggggggga  aggcttggg  1380
tatagctca  gggcagaac  ctgtccagc  gccacagtg  tgaagagaa  ggagaaaga  1440
tcccaaggc  gcttttcct  tgtcaggaa  actaagcct  aatcaagca  atcagcttg  1500
caatgtccc  ggacccatt  ggggcattt  cctcaggcc  ccctctatg  cctactcag  1560
gtctctgag  gtcagactc  agcgttgtt  tcagtctct  ggccctcac  caggctcag  1620
acgagaagg  ccatgccca  gagtcctgg  cagagaccc  ggagtctcc  gccccatag  1680
tgtcagact  acatcctaa  gcagacaaa  gaacagcgc  gggaggtgc  tgtgctcct  1740
ctggtgtct  gattgtgga  accctaatc  catcccagg  ctcctgacc  tcccaggat  1800
gtcacatgg  caatactgt  tccctggaa  aaagctaga  gcctcagtc  tacaagtct  1860
tccctcaga  cccccaaag  cacatgtga  ccttcaccc  agacctgaa  gtgatgtca  1920
cctgaggtg  tgggccctg  gcttctacc  tgctgacat  accttgacc  ggcaattga  1980
tggggagga  ctgacccag  acatggagc  tgtggagac  aggcctgca  gggatggaa  2040
cttccagaa  tgggcagct  tggtagtgc  ttctgggga  gagctaaag  acacatgcc  2100
tgtggagca  gagggactg  ctgaacctc  cgccctgag  tggggtaag  agggtgtgg  2160
tgcagatct  gggtcaggg  atgtggagc  ttctgcaga  cctgagctg  tcagggatg  2220
gaatcatga  tcttccttc  cagagcctt  tccattcac  gactccagc  tgccagtga  2280
tgttgtcct  ggagctgtg  ccatcattg  agctgtggc  atcattgga  ctgtggcca  2340
cattggagc  gttgtgagg  ggaggaaga  aaacacagg  aggaaaggg  agggtctga  2400
tcttctctc  gcctctttg  agtgtgctg  gctcattaa  gggaaacac  gccacaccc  2460
gcattgcct  gtctctaac  tggactgct  tcagtgctg  aaacttcct  gggctggtg  2520
ttccctgac  tctcatgac  ttccttctc  acaggtgaa  aaggcagct  tgctcatgt  2580
ctaggtagg  gtgggtggg  ttggccgtg  agtggggtg  acccttgta  ccagaggcc  2640
ttgggatgg  agctggcgc  tatggagga  ttctgccag  cccataatt  cctcttgcc  2700
tattggtca  ctgaatata  ctgcattta  aattcctct  ctcaggcag  aaggctttc  2760
agatctctg  ctggcctca  aaggcatga  aaggtatga  aacccatgg  ggcctggga  2820
cggacctga  gcaaaggga  gaacagggc  ttgtgggat  atgtcacag  tgaggcagg  2880
acaagatag  aggaggcct  ttattggat  agaaagaag  atgggtggg  gacaagttt  2940
aaggaagaa  aggatactg  aacagagag  gaggaggag  ggagggaga  ggagagaag  3000
cttggcagg  aatatatca  gtgacgtta  gattctcct  tgtgtactt  gaggttgtt  3060
ttaatgttc  taagggatg  atggtaccg  gctttgtat  tttaactcg  caattatat  3120
ttatcaatt  gctctaaga  tattgttgg  gtgttcttt  atgtgatgg  ttgagtgta  3180
gaaagtgtg  agtgacagg  gacgatggg  cagcacaga  ttgggatgt  tttccaccc  3240
agatatcta  cagatatct  ggggcactg  agtgcagac  tagcggggt  aaagacaac  3300
atacttttt  tacttttta  atttttaca  caacagggt  tctcagatt  agacatttg  3360
atgactgag  atctttaca  tgacttcag  actcttgtt  tattgcgtt  agacagttg  3420
ctcgtgggg  tgagcgaca  gttctgact  aacatctga  ggagctgct  cccctgagg  3480
caatgtgaa  aactggcaa  cccagacct  cttgcctcc  tggacacct  acttcacaa  3540
agaaaataa  ctgactctg  gctgggtgt  tcctattgc  tttatctgc  ctgagtgga  3600
atgcgattt  caacagtgt  acgcagcac  gttgtgtgg  ggtagtgac  ttgcacaca  3660
gtttgtgag  tgggggtgt  atgtgcttt  cttactgta  gcagaacaa  ctagaagtc  3720
accattcct  ttatggtca  tgttttaaa  caaaacaaa  gctggagag  tggctcagt  3780
ttaagagca  tgacttctc  tacagaggt  ctggttcaa  tcccagcaa  cacatggtg  3840
ctcacaacc  tatgtaatg  gatctgatg  tctcttctg  tgtgtctga  cacagctat  3900
tatgataaa  aaatctaaa  aatattttt  aaatggcca  acagatggc  tgagtaggg  3960
acaccatgg  caactctgc  gtctgtgta  ctctagaca  ccagtgctc  ttagagtcc  4020
cacaaggtc  ttaaaagga  tggggtgga  ggtgactgg  gagatagct  agtggttaa  4080
agtgtttgc  gcttcatgg  tggtggtgg  ggcacaagc  tttaatcca  acactcagg  4140
ggcagaggc  ggtggatct  tgagttcaa  gccagcctg  cctataagg  aagttccaa  4200
atagccaag  atacacaga  aaaccctgt  tgaaaaaac  caagcctag  cctggagag  4260
tggctcaat  gttaagagc  ctgactgct  ttccagagg  cctgagttc  aggcccagc  4320
aaggcacat  gtggctcac  accatctgt  atgggatct  atgcacttt  ctggtgtgt  4380
taaagcgac  tggtaactc  ctgtctgta  ctagtaggc  aacagttca  atctcacac  4440
gacatgaat  cagatagag  accaacaca  ataaaatta  atctttaaa  aatgaaagg  4500
ctgggggct  gatgaatgg  gtttgtctt  gaaatgtct  acagtgctg  gactcacag  4560
ctgcatagc  gctcctatt  cctggtgtt  accatctgt  ttggttata  aaaggtttc  4620
taatgtgaa  cccttcaaa  gagctggtg  ccttctcac  agtttgcat  ttgacagga  4680
tcctgaagg  cttatattc  gggccttcc  attgtggag  attaggttt  acacaacgt  4740
tcctctcta  cattgcaat  tccctgagc  ttaaaatcc  ttcatcgac  ctgagccaa  4800
ggatatctg  catctgcaa  tccttttcc  taggccgtc  tttgatgaa  gcttcagcc  4860
accattcaa  caaactttc  gacactttt  tttaactgt  tggccttcc  tattaaacc  4920
agaatctcc  ctcaaaggg  ccatgtcaa  aaactcagc  tgatctatt  4969



<210> 605
<211> 1665
<212> DNA
<213> Homo sapiens
<308> M20022
<400> 605

cgggatcat  gtagatgga  ccctccttt  actctcctc  gaggccctg  cccttaccc  60
gacctgggc  ggctcccac  ccttgaagt  tttccacac  tccgtgtcc  ggcccggcc  120
cggggagcc  cgcttcatc  ctgtgggct  cgtggacga  acccagttc  tgcgcttcg  180
caacgacgc  gcgagtccg  ggatggtgc  gcgggcgcc  tggatggag  aggaggggt  240
agagtattg  gaccgggag  cacggagcg  cagggacac  gcacagatt  tccgagtga  300
cctgcggac  ctgcgcggc  actacaatc  gagcgaggc  gggtctcac  ccctgcagt  360
gatgcatgg  tgcgagctg  ggcccgaca  gcgcttcct  cgcgggtat  aacagttcg  420
ctacgacgg  aaggattat  tcaccctga  tgaggacct  cgctcctgg  ccgcggtgg  480
cacggcggc  cagatctcc  agcaaaagt  aaatgatgc  tctgaggcg  agcaccaga  540
agcctacct  gaagacaca  gcgtggagt  gctccacaa  tacctggag  aggggaagg  600
gacgctgct  cacctggag  ccccaaaga  acacgtgac  caccacccc  tctctgacc  660
tgaggccac  ctgaggtgc  gggccctgg  cttctaccc  gcggagatc  cactgacct  720
gcagcagga  ggggagggc  atacccagg  cacggagct  gtggagacc  ggcctgcag  780
ggatggaac  ttccagaag  gggcagctg  ggtggtgcc  tctggagag  agcagagat  840
cacgtgcca  gtgcagcat  aggggctac  cgagcccgt  accctgaga  ggaagccgg  900
ttcccagcc  accatcccc  tcgtgggca  cattgctgg  ctggttctc  ttggatctg  960
ggtctctgg  gctgtggtt  ctgctgtga  atggaggaa  aagagctca  gtggaaaag  1020
agggagcta  tctaaggct  agtggagcg  cagtgccca  gggtctgag  ctcacagct  1080
gtaaagcct  agacagctg  cttgtgtgc  actgagatg  acagctgcc  tgtgtgcga  1140
tgagatgca  gatttcctc  cgcctcccc  atgtgtctt  ggggactct  gcttctctt  1200
ttgcaaggg  ctctgaatc  gtctgtgtc  ctgttagca  aatgtgagg  ggtagagaa  1260
cagtccacc  ctgtgtcta  catgacccc  ttcctcaca  tgacctgtg  tccttccct  1320
ttctctttt  tattaaaaa  aagaacctg  gcagagtgc  gcagctcat  cctgtaatc  1380
cagcactta  ggaggccga  gagggcaga  cacgaggtc  ggagatcga  accatcctg  1440
ctaacacgg  gaaaccccg  ctctactaa  aaatacaaa  aattagctg  gcgcagagg  1500
acgggcctg  agtcccagc  actcaggag  cggaggcat  gagaatggc  tcaacccgg  1560
aggcggagg  tgcagtgag  caggattgt  cgactgcac  ccagcctgg  tgacagggt  1620
aaacgccat  tcaaaaaat  aaaattaaa  aataaaaaa  gaacc  1665



<210> 606
<211> 623
<212> PRT
<213> Homo sapiens
<308> P29401
<400> 606

Met Glu Ser Tyr His Lys Pro Asp Gln Gln Lys Leu Gln Ala Leu Lys 
  1               5                  10                  15
Asp Thr Ala Asn Arg Leu Arg Ile Ser Ser Ile Gln Ala Thr Thr Ala 
             20                  25                  30
Ala Gly Ser Gly His Pro Thr Ser Cys Cys Ser Ala Ala Glu Ile Met 
         35                  40                  45
Ala Val Leu Phe Phe His Thr Met Arg Tyr Lys Ser Gln Asp Pro Arg 
     50                  55                  60
Asn Pro His Asn Asp Arg Phe Val Leu Ser Lys Gly His Ala Ala Pro 
 65                  70                  75                  80
Ile Leu Tyr Ala Val Trp Ala Glu Ala Gly Phe Leu Ala Glu Ala Glu 
                 85                  90                  95
Leu Leu Asn Leu Arg Lys Ile Ser Ser Asp Leu Asp Gly His Pro Val 
             100                105                110
Pro Lys Gln Ala Phe Thr Asp Val Ala Thr Gly Ser Leu Gly Gln Gly 
         115                120                125
Leu Gly Ala Ala Cys Gly Met Ala Tyr Thr Gly Lys Tyr Phe Asp Lys 
     130                135                140
Ala Ser Tyr Arg Val Tyr Cys Leu Leu Gly Asp Gly Glu Leu Ser Glu 
 145                150                155                160
Gly Ser Val Trp Glu Ala Met Ala Phe Ala Ser Ile Tyr Lys Leu Asp 
                 165                170                175
Asn Leu Val Ala Ile Leu Asp Ile Asn Arg Leu Gly Gln Ser Asp Pro 
             180                185                190
Ala Pro Leu Gln His Gln Met Asp Ile Tyr Gln Lys Arg Cys Glu Ala 
         195                200                205
Phe Gly Trp His Ala Ile Ile Val Asp Gly His Ser Val Glu Glu Leu 
     210                215                220
Cys Lys Ala Phe Gly Gln Ala Lys His Gln Pro Thr Ala Ile Ile Ala 
 225                230                235                240
Lys Thr Phe Lys Gly Arg Gly Ile Thr Gly Val Glu Asp Lys Glu Ser 
                 245                250                255
Trp His Gly Lys Pro Leu Pro Lys Asn Met Ala Glu Gln Ile Ile Gln 
             260                265                270
Glu Ile Tyr Ser Gln Ile Gln Ser Lys Lys Lys Ile Leu Ala Thr Pro 
         275                280                285
Pro Gln Glu Asp Ala Pro Ser Val Asp Ile Ala Asn Ile Arg Met Pro 
     290                295                300
Ser Leu Pro Ser Tyr Lys Val Gly Asp Lys Ile Ala Thr Arg Lys Ala 
 305                310                315                320
Tyr Gly Gln Ala Leu Ala Lys Leu Gly His Ala Ser Asp Arg Ile Ile 
                 325                330                335
Ala Leu Asp Gly Asp Thr Lys Asn Ser Thr Phe Ser Glu Ile Phe Lys 
             340                345                350
Lys Glu His Pro Asp Arg Phe Ile Glu Cys Tyr Ile Ala Glu Gln Asn 
         355                360                365
Met Val Ser Ile Ala Val Gly Cys Ala Thr Arg Asn Arg Thr Val Pro 
     370                375                380
Phe Cys Ser Thr Phe Ala Ala Phe Phe Thr Arg Ala Phe Asp Gln Ile 
 385                390                395                400
Arg Met Ala Ala Ile Ser Glu Ser Asn Ile Asn Leu Cys Gly Ser His 
                 405                410                415
Cys Gly Val Ser Ile Gly Glu Asp Gly Pro Ser Gln Met Ala Leu Glu 
             420                425                430
Asp Leu Ala Met Phe Arg Ser Val Pro Thr Ser Thr Val Phe Tyr Pro 
         435                440                445
Ser Asp Gly Val Ala Thr Glu Lys Ala Val Glu Leu Ala Ala Asn Thr 
     450                455                460
Lys Gly Ile Cys Phe Ile Arg Thr Ser Arg Pro Glu Asn Ala Ile Ile 
 465                470                475                480
Tyr Asn Asn Asn Glu Asp Phe Gln Val Gly Gln Ala Lys Val Val Leu 
                 485                490                495
Lys Ser Lys Asp Asp Gln Val Thr Val Ile Gly Ala Gly Val Thr Leu 
             500                505                510
His Glu Ala Leu Ala Ala Ala Glu Leu Leu Lys Lys Glu Lys Ile Asn 
         515                520                525
Ile Arg Val Leu Asp Pro Phe Thr Ile Lys Pro Leu Asp Arg Lys Leu 
     530                535                540
Ile Leu Asp Ser Ala Arg Ala Thr Lys Gly Arg Ile Leu Thr Val Glu 
 545                550                555                560
Asp His Tyr Tyr Glu Gly Gly Ile Gly Glu Ala Val Ser Ser Ala Val 
                 565                570                575
Val Gly Glu Pro Gly Ile Thr Val Thr His Leu Ala Val Asn Arg Val 
             580                585                590
Pro Arg Ser Gly Lys Pro Ala Glu Leu Leu Lys Met Phe Gly Ile Asp 
         595                600                605
Arg Asp Ala Ile Ala Gln Ala Val Arg Gly Leu Ile Thr Lys Ala 
     610                615                620



<210> 607
<211> 4969
<212> DNA
<213> Rattus norvegicus
<308> AF029240
<400> 607

aagcttaca  agaccctac  acaagactt  gtgaaaccg  gtgcccaag  gcacaagtg  60
ggttccgtg  ggtttagtg  ggtttacac  acaggaggt  gtgtaaaca  ctcctgctg  120
tttctcttt  ataaagaca  aagtgatac  gtctcgcct  tcgttcctg  tggacgcag  180
cgtctgtag  agccaatca  cagcacaga  gttccaaag  acgagtcaa  agaaacaca  240
cccacattc  tgtttttca  agtccctgg  cgtgaggat  ttacctcct  cctatttgc  300
ccaactact  gcaggcacc  tggtcctga  ccagactag  aagtgcggg  aggggtcgg  360
aaagaaaag  ctctgagag  tgaaagggg  tggggtgtg  ggccagggg  ggtggcggg  420
gggggcagc  ccctagggt  tgtcaccct  tcccagtcc  tcctctgcc  gcacctgag  480
tcctgagcc  agaggagct  agggtctca  tgcgcgccg  ccccaggct  acactcgct  540
cggtatttc  acaccgccc  gtcccggcc  ggcctcggg  agcccaggt  cattgtcgt  600
ggctacgtg  acgacacgc  gttcgtgcg  tatgacagc  atgtggaga  tccgaggat  660
gagccacgg  cgcggtgga  ggagcagga  gagccggca  attgggagc  ggagactcg  720
aaagccagg  acaccggga  gaacttcaa  gtgaatctg  ggaccctgc  ccgctacta  780
aatcagagt  acgacggtt  agttgactg  cggagggat  acaaacagg  tccctccat  840
ttccctgag  ctggcctgg  tcatcttga  cccggccgg  tcaaagtat  atccaaacg  900
ctacctaga  atcccagac  agaaagccc  ggcagagtt  tgcttaggt  tcggttgca  960
ttttgtttc  aaaaattct  gcatatcta  tgacagcgg  caagatggc  acgaggggg  1020
gctgaaccg  cgtttcccc  ttcagaatc  cacacgctg  agtggatgt  cggctgcga  1080
gtggggccc  atgggcacc  gctccgcgg  tattgtcag  aggcttatg  cggccggga  1140
tatatctcc  tgaacgagg  cctgcgctc  tggaccgcg  ctgacatgg  ctcacaggc  1200
tctaagatc  agtcagagg  agttggtga  gcccatcac  agagggcct  cctgcaagg  1260
ccttgcgtg  agtggctcc  cacatacct  catctggga  aggagacgc  gctgcgctc  1320
ggtgccctg  agacccctc  ttagttttc  tctgggggt  tggggggga  aggcttggg  1380
tatagctca  gggcagaac  ctgtccagc  gccacagtg  tgaagagaa  ggagaaaga  1440
tcccaaggc  gcttttcct  tgtcaggaa  actaagcct  aatcaagca  atcagcttg  1500
caatgtccc  ggacccatt  ggggcattt  cctcaggcc  ccctctatg  cctactcag  1560
gtctctgag  gtcagactc  agcgttgtt  tcagtctct  ggccctcac  caggctcag  1620
acgagaagg  ccatgccca  gagtcctgg  cagagaccc  ggagtctcc  gccccatag  1680
tgtcagact  acatcctaa  gcagacaaa  gaacagcgc  gggaggtgc  tgtgctcct  1740
ctggtgtct  gattgtgga  accctaatc  catcccagg  ctcctgacc  tcccaggat  1800
gtcacatgg  caatactgt  tccctggaa  aaagctaga  gcctcagtc  tacaagtct  1860
tccctcaga  cccccaaag  cacatgtga  ccttcaccc  agacctgaa  gtgatgtca  1920
cctgaggtg  tgggccctg  gcttctacc  tgctgacat  accttgacc  ggcaattga  1980
tggggagga  ctgacccag  acatggagc  tgtggagac  aggcctgca  gggatggaa  2040
cttccagaa  tgggcagct  tggtagtgc  ttctgggga  gagctaaag  acacatgcc  2100
tgtggagca  gagggactg  ctgaacctc  cgccctgag  tggggtaag  agggtgtgg  2160
tgcagatct  gggtcaggg  atgtggagc  ttctgcaga  cctgagctg  tcagggatg  2220
gaatcatga  tcttccttc  cagagcctt  tccattcac  gactccagc  tgccagtga  2280
tgttgtcct  ggagctgtg  ccatcattg  agctgtggc  atcattgga  ctgtggcca  2340
cattggagc  gttgtgagg  ggaggaaga  aaacacagg  aggaaaggg  agggtctga  2400
tcttctctc  gcctctttg  agtgtgctg  gctcattaa  gggaaacac  gccacaccc  2460
gcattgcct  gtctctaac  tggactgct  tcagtgctg  aaacttcct  gggctggtg  2520
ttccctgac  tctcatgac  ttccttctc  acaggtgaa  aaggcagct  tgctcatgt  2580
ctaggtagg  gtgggtggg  ttggccgtg  agtggggtg  acccttgta  ccagaggcc  2640
ttgggatgg  agctggcgc  tatggagga  ttctgccag  cccataatt  cctcttgcc  2700
tattggtca  ctgaatata  ctgcattta  aattcctct  ctcaggcag  aaggctttc  2760
agatctctg  ctggcctca  aaggcatga  aaggtatga  aacccatgg  ggcctggga  2820
cggacctga  gcaaaggga  gaacagggc  ttgtgggat  atgtcacag  tgaggcagg  2880
acaagatag  aggaggcct  ttattggat  agaaagaag  atgggtggg  gacaagttt  2940
aaggaagaa  aggatactg  aacagagag  gaggaggag  ggagggaga  ggagagaag  3000
cttggcagg  aatatatca  gtgacgtta  gattctcct  tgtgtactt  gaggttgtt  3060
ttaatgttc  taagggatg  atggtaccg  gctttgtat  tttaactcg  caattatat  3120
ttatcaatt  gctctaaga  tattgttgg  gtgttcttt  atgtgatgg  ttgagtgta  3180
gaaagtgtg  agtgacagg  gacgatggg  cagcacaga  ttgggatgt  tttccaccc  3240
agatatcta  cagatatct  ggggcactg  agtgcagac  tagcggggt  aaagacaac  3300
atacttttt  tacttttta  atttttaca  caacagggt  tctcagatt  agacatttg  3360
atgactgag  atctttaca  tgacttcag  actcttgtt  tattgcgtt  agacagttg  3420
ctcgtgggg  tgagcgaca  gttctgact  aacatctga  ggagctgct  cccctgagg  3480
caatgtgaa  aactggcaa  cccagacct  cttgcctcc  tggacacct  acttcacaa  3540
agaaaataa  ctgactctg  gctgggtgt  tcctattgc  tttatctgc  ctgagtgga  3600
atgcgattt  caacagtgt  acgcagcac  gttgtgtgg  ggtagtgac  ttgcacaca  3660
gtttgtgag  tgggggtgt  atgtgcttt  cttactgta  gcagaacaa  ctagaagtc  3720
accattcct  ttatggtca  tgttttaaa  caaaacaaa  gctggagag  tggctcagt  3780
ttaagagca  tgacttctc  tacagaggt  ctggttcaa  tcccagcaa  cacatggtg  3840
ctcacaacc  tatgtaatg  gatctgatg  tctcttctg  tgtgtctga  cacagctat  3900
tatgataaa  aaatctaaa  aatattttt  aaatggcca  acagatggc  tgagtaggg  3960
acaccatgg  caactctgc  gtctgtgta  ctctagaca  ccagtgctc  ttagagtcc  4020
cacaaggtc  ttaaaagga  tggggtgga  ggtgactgg  gagatagct  agtggttaa  4080
agtgtttgc  gcttcatgg  tggtggtgg  ggcacaagc  tttaatcca  acactcagg  4140
ggcagaggc  ggtggatct  tgagttcaa  gccagcctg  cctataagg  aagttccaa  4200
atagccaag  atacacaga  aaaccctgt  tgaaaaaac  caagcctag  cctggagag  4260
tggctcaat  gttaagagc  ctgactgct  ttccagagg  cctgagttc  aggcccagc  4320
aaggcacat  gtggctcac  accatctgt  atgggatct  atgcacttt  ctggtgtgt  4380
taaagcgac  tggtaactc  ctgtctgta  ctagtaggc  aacagttca  atctcacac  4440
gacatgaat  cagatagag  accaacaca  ataaaatta  atctttaaa  aatgaaagg  4500
ctgggggct  gatgaatgg  gtttgtctt  gaaatgtct  acagtgctg  gactcacag  4560
ctgcatagc  gctcctatt  cctggtgtt  accatctgt  ttggttata  aaaggtttc  4620
taatgtgaa  cccttcaaa  gagctggtg  ccttctcac  agtttgcat  ttgacagga  4680
tcctgaagg  cttatattc  gggccttcc  attgtggag  attaggttt  acacaacgt  4740
tcctctcta  cattgcaat  tccctgagc  ttaaaatcc  ttcatcgac  ctgagccaa  4800
ggatatctg  catctgcaa  tccttttcc  taggccgtc  tttgatgaa  gcttcagcc  4860
accattcaa  caaactttc  gacactttt  tttaactgt  tggccttcc  tattaaacc  4920
agaatctcc  ctcaaaggg  ccatgtcaa  aaactcagc  tgatctatt  4969



<210> 608
<211> 1665
<212> DNA
<213> Homo sapiens
<308> M20022
<400> 608

cgggatcat  gtagatgga  ccctccttt  actctcctc  gaggccctg  cccttaccc  60
gacctgggc  ggctcccac  ccttgaagt  tttccacac  tccgtgtcc  ggcccggcc  120
cggggagcc  cgcttcatc  ctgtgggct  cgtggacga  acccagttc  tgcgcttcg  180
caacgacgc  gcgagtccg  ggatggtgc  gcgggcgcc  tggatggag  aggaggggt  240
agagtattg  gaccgggag  cacggagcg  cagggacac  gcacagatt  tccgagtga  300
cctgcggac  ctgcgcggc  actacaatc  gagcgaggc  gggtctcac  ccctgcagt  360
gatgcatgg  tgcgagctg  ggcccgaca  gcgcttcct  cgcgggtat  aacagttcg  420
ctacgacgg  aaggattat  tcaccctga  tgaggacct  cgctcctgg  ccgcggtgg  480
cacggcggc  cagatctcc  agcaaaagt  aaatgatgc  tctgaggcg  agcaccaga  540
agcctacct  gaagacaca  gcgtggagt  gctccacaa  tacctggag  aggggaagg  600
gacgctgct  cacctggag  ccccaaaga  acacgtgac  caccacccc  tctctgacc  660
tgaggccac  ctgaggtgc  gggccctgg  cttctaccc  gcggagatc  cactgacct  720
gcagcagga  ggggagggc  atacccagg  cacggagct  gtggagacc  ggcctgcag  780
ggatggaac  ttccagaag  gggcagctg  ggtggtgcc  tctggagag  agcagagat  840
cacgtgcca  gtgcagcat  aggggctac  cgagcccgt  accctgaga  ggaagccgg  900
ttcccagcc  accatcccc  tcgtgggca  cattgctgg  ctggttctc  ttggatctg  960
ggtctctgg  gctgtggtt  ctgctgtga  atggaggaa  aagagctca  gtggaaaag  1020
agggagcta  tctaaggct  agtggagcg  cagtgccca  gggtctgag  ctcacagct  1080
gtaaagcct  agacagctg  cttgtgtgc  actgagatg  acagctgcc  tgtgtgcga  1140
tgagatgca  gatttcctc  cgcctcccc  atgtgtctt  ggggactct  gcttctctt  1200
ttgcaaggg  ctctgaatc  gtctgtgtc  ctgttagca  aatgtgagg  ggtagagaa  1260
cagtccacc  ctgtgtcta  catgacccc  ttcctcaca  tgacctgtg  tccttccct  1320
ttctctttt  tattaaaaa  aagaacctg  gcagagtgc  gcagctcat  cctgtaatc  1380
cagcactta  ggaggccga  gagggcaga  cacgaggtc  ggagatcga  accatcctg  1440
ctaacacgg  gaaaccccg  ctctactaa  aaatacaaa  aattagctg  gcgcagagg  1500
acgggcctg  agtcccagc  actcaggag  cggaggcat  gagaatggc  tcaacccgg  1560
aggcggagg  tgcagtgag  caggattgt  cgactgcac  ccagcctgg  tgacagggt  1620
aaacgccat  tcaaaaaat  aaaattaaa  aataaaaaa  gaacc  1665



<210> 609
<211> 623
<212> PRT
<213> Homo sapiens
<308> P29401
<400> 609

Met Glu Ser Tyr His Lys Pro Asp Gln Gln Lys Leu Gln Ala Leu Lys 
  1               5                  10                  15
Asp Thr Ala Asn Arg Leu Arg Ile Ser Ser Ile Gln Ala Thr Thr Ala 
             20                  25                  30
Ala Gly Ser Gly His Pro Thr Ser Cys Cys Ser Ala Ala Glu Ile Met 
         35                  40                  45
Ala Val Leu Phe Phe His Thr Met Arg Tyr Lys Ser Gln Asp Pro Arg 
     50                  55                  60
Asn Pro His Asn Asp Arg Phe Val Leu Ser Lys Gly His Ala Ala Pro 
 65                  70                  75                  80
Ile Leu Tyr Ala Val Trp Ala Glu Ala Gly Phe Leu Ala Glu Ala Glu 
                 85                  90                  95
Leu Leu Asn Leu Arg Lys Ile Ser Ser Asp Leu Asp Gly His Pro Val 
             100                105                110
Pro Lys Gln Ala Phe Thr Asp Val Ala Thr Gly Ser Leu Gly Gln Gly 
         115                120                125
Leu Gly Ala Ala Cys Gly Met Ala Tyr Thr Gly Lys Tyr Phe Asp Lys 
     130                135                140
Ala Ser Tyr Arg Val Tyr Cys Leu Leu Gly Asp Gly Glu Leu Ser Glu 
 145                150                155                160
Gly Ser Val Trp Glu Ala Met Ala Phe Ala Ser Ile Tyr Lys Leu Asp 
                 165                170                175
Asn Leu Val Ala Ile Leu Asp Ile Asn Arg Leu Gly Gln Ser Asp Pro 
             180                185                190
Ala Pro Leu Gln His Gln Met Asp Ile Tyr Gln Lys Arg Cys Glu Ala 
         195                200                205
Phe Gly Trp His Ala Ile Ile Val Asp Gly His Ser Val Glu Glu Leu 
     210                215                220
Cys Lys Ala Phe Gly Gln Ala Lys His Gln Pro Thr Ala Ile Ile Ala 
 225                230                235                240
Lys Thr Phe Lys Gly Arg Gly Ile Thr Gly Val Glu Asp Lys Glu Ser 
                 245                250                255
Trp His Gly Lys Pro Leu Pro Lys Asn Met Ala Glu Gln Ile Ile Gln 
             260                265                270
Glu Ile Tyr Ser Gln Ile Gln Ser Lys Lys Lys Ile Leu Ala Thr Pro 
         275                280                285
Pro Gln Glu Asp Ala Pro Ser Val Asp Ile Ala Asn Ile Arg Met Pro 
     290                295                300
Ser Leu Pro Ser Tyr Lys Val Gly Asp Lys Ile Ala Thr Arg Lys Ala 
 305                310                315                320
Tyr Gly Gln Ala Leu Ala Lys Leu Gly His Ala Ser Asp Arg Ile Ile 
                 325                330                335
Ala Leu Asp Gly Asp Thr Lys Asn Ser Thr Phe Ser Glu Ile Phe Lys 
             340                345                350
Lys Glu His Pro Asp Arg Phe Ile Glu Cys Tyr Ile Ala Glu Gln Asn 
         355                360                365
Met Val Ser Ile Ala Val Gly Cys Ala Thr Arg Asn Arg Thr Val Pro 
     370                375                380
Phe Cys Ser Thr Phe Ala Ala Phe Phe Thr Arg Ala Phe Asp Gln Ile 
 385                390                395                400
Arg Met Ala Ala Ile Ser Glu Ser Asn Ile Asn Leu Cys Gly Ser His 
                 405                410                415
Cys Gly Val Ser Ile Gly Glu Asp Gly Pro Ser Gln Met Ala Leu Glu 
             420                425                430
Asp Leu Ala Met Phe Arg Ser Val Pro Thr Ser Thr Val Phe Tyr Pro 
         435                440                445
Ser Asp Gly Val Ala Thr Glu Lys Ala Val Glu Leu Ala Ala Asn Thr 
     450                455                460
Lys Gly Ile Cys Phe Ile Arg Thr Ser Arg Pro Glu Asn Ala Ile Ile 
 465                470                475                480
Tyr Asn Asn Asn Glu Asp Phe Gln Val Gly Gln Ala Lys Val Val Leu 
                 485                490                495
Lys Ser Lys Asp Asp Gln Val Thr Val Ile Gly Ala Gly Val Thr Leu 
             500                505                510
His Glu Ala Leu Ala Ala Ala Glu Leu Leu Lys Lys Glu Lys Ile Asn 
         515                520                525
Ile Arg Val Leu Asp Pro Phe Thr Ile Lys Pro Leu Asp Arg Lys Leu 
     530                535                540
Ile Leu Asp Ser Ala Arg Ala Thr Lys Gly Arg Ile Leu Thr Val Glu 
 545                550                555                560
Asp His Tyr Tyr Glu Gly Gly Ile Gly Glu Ala Val Ser Ser Ala Val 
                 565                570                575
Val Gly Glu Pro Gly Ile Thr Val Thr His Leu Ala Val Asn Arg Val 
             580                585                590
Pro Arg Ser Gly Lys Pro Ala Glu Leu Leu Lys Met Phe Gly Ile Asp 
         595                600                605
Arg Asp Ala Ile Ala Gln Ala Val Arg Gly Leu Ile Thr Lys Ala 
     610                615                620



<210> 610
<211> 3312
<212> DNA
<213> Rattus norvegicus
<308> AF030050
<400> 610

atggacatt  ggaaattct  tggggttat  tcaagtgga  aaaagcctg  aaatgagac  60
gtaaagaag  atgagaaga  aaaaccttc  gagggaact  tcaaaggaa  gaaaggagt  120
aaggttgcc  aggttaata  tccctgcaa  gaggatgcc  ccagaccaa  gcagcacac  180
gaaaaacga  gatcatcta  gactcagat  cagaatcag  ggagacacg  gcaagtgaa  240
gatgctaaa  agaaatcag  aaaattgcc  cgtgtgctt  taaacctgg  aaatctctc  300
gaaggatcc  cgttacctc  tatttctga  acagatgaa  acgcagtga  tttttatgt  360
aaaaggcag  ctccaaatc  aaagagaat  gagtatcta  gaaacagtt  ccttggagc  420
tcaaacgtg  aaaagaatg  agaaaacac  aagactaag  gtaaaccgt  atcaccaat  480
aaactaaca  cgacatcag  gcttgatta  tttggaact  aaagtgtcc  gagatctgg  540
aagaagatg  tggcgagca  aaagaaaga  tcttctcaa  ccccagatg  ttccagatt  600
aatgatgag  ccatcgcca  gcagctgca  cttgatgaa  atgcagagc  ggagaggca  660
ttgcatgaa  atgaagaat  tgcaagaac  ctggccttg  tggatgaag  acctaagac  720
aaaaaggct  gaaaggact  tgaagaggg  gaatcattt  cacctgcca  agctgagtt  780
agcaaagca  caaagcaga  gagccctgc  aacgagcat  tctcaattg  aagaaagac  840
tacagtcct  ctaagtacg  caagggtag  ggctcagaa  gcaccaagc  gccctgcag  900
tcagctcac  agacggaag  ctgctcctc  ctcaaggcc  gctccaagc  ggctcttat  960
aaagcacaa  aagaaaact  tcacacaga  acagaactg  tggctgcaa  aagagaaag  1020
gccattgag  ccaaaggag  gaaaacaac  cctaggaaa  cgaaaggct  tccaactaa  1080
agagagtct  taagcccag  agattctga  aagaagcgc  ccaattatc  agcttatcg  1140
agctactta  atcgagaag  tcccaaagc  ctgggctcc  aagaaatac  caagggagc  1200
gaaaactgc  tggagggcc  gacgttcgt  atcaccgga  tgctggagt  catcgaacg  1260
gaagaagcc  agtctctaa  tgaacgtta  ggggggaaa  taacaggaa  cgtgagcaa  1320
aaaaccagc  acctcgtca  gggccggga  agcaggcag  ccaagagtg  caaggcagc  1380
gctctggga  caaaaatcc  tgatgaaga  ggcctgttg  atctgattc  aactatgcc  1440
ggcaaaaaa  ccaagtacg  aatcgctgc  gaggctgag  tgaagaaag  aaagtccaa  1500
ttggagaga  caccccaaa  aaatgatca  ggaaaaaga  aacttagtc  aaccaagag  1560
gagttggag  ctaaaaaga  caagctgac  ccccttaag  acagccctc  gaaggcagt  1620
aaggaggag  aacgtgtgt  tccgagggg  ttggacgcc  aggagcctc  tggcagcca  1680
agtgccagc  gagaggagt  cctgctctg  gtggataag  acaagccca  ctcactcaa  1740
aacataatc  gacagcagg  tgaccagag  tgtgccaac  aactgctac  ctggctcag  1800
aactggcac  agagttctc  agaagagaa  aagcatgca  aatttggca  agttgccag  1860
aaagatgat  gctccagtt  caaggcagc  ctgctgtct  gccctccag  tgttggcaa  1920
accactaca  cttctcttg  gtgtcagga  ttgggctac  gttatgtgg  actaaatgc  1980
agtgatact  ggagtaaga  cagtctgaa  gcaattgtt  ctgagtcat  gaacaacac  2040
agcatcaaa  gcttttata  aagtggagc  tctccttct  taagtgcga  gcatgctct  2100
atcatggat  aagttgatg  catggcggg  aatgaggac  ggggtggaa  tcaggagct  2160
ataggcctg  taaagcata  gaaaattcc  atcatttgt  tgtgcaatg  tagaaatca  2220
cccaaaatc  gctcattgg  tcattattg  tttgatctt  gtttccaaa  acctcgagt  2280
gaacagatt  agagtgcaa  gctgtctat  gcatttaaa  agggattaa  gatcccacc  2340
ccagctatg  atgaaataa  tttgggagc  aatcaagat  tcagacagg  tttacacaa  2400
ctcagtatg  ggtgtgcac  gagtaaggt  ctaacctat  accaagcca  ggctgattc  2460
cagagggcc  agaaggaca  cagattggg  ccatttgat  tcacccgga  agtgtttgc  2520
gctggagag  agactccac  catgtcact  atggacaaa  cggatctct  tttccatga  2580
tattccatt  cacccctct  tgtccagga  aactacctc  atgtaaagc  tgtggctgc  2640
gggggtgac  tgaaaaagc  cttgatgct  ttaagccgg  cagcagata  catatgtga  2700
ggtgactta  tggccaatc  gatccggag  aagcaaaac  ggagtctct  ccacacagg  2760
catttacgc  agcgttgtt  ctggagagt  gatgagggg  tacatgtct  agtttccca  2820
cttcccaag  ctggctggg  aagcactcg  ctatgggca  gcactgatc  gactgttca  2880
gacctgtcc  tgcacatga  tcttagaac  tactccagc  aaaggacag  gaacatgga  2940
tacctgtca  acatcagag  cgcacttgt  cgacccttg  cctcacaag  agtagaagg  3000
gttcagcgt  ttgtcacac  tatgttggt  aaagaagat  ttgacaaca  catggaagt  3060
agcagcgat  catactatt  ggggggcaa  cccagtacc  tttccaagc  ggaccccaa  3120
gtgaaagca  ccttcacaa  agcctataa  aaggaggcc  acctgaccc  atactcact  3180
caggtggta  aggcatcga  gcccagcat  ggtccagca  tggattctg  gtacaatga  3240
gagtcacag  aagatgcca  tcagtctga  gagaaagag  aggatgccc  agagactga  3300
gccatgatc  ag  3312



<210> 611
<211> 1104
<212> PRT
<213> Rattus norvegicus
<308> AAD01890
<400> 611

Met Asp Ile Arg Lys Phe Phe Gly Val Ile Ser Ser Gly Lys Lys Pro 
  1               5                  10                  15
Val Asn Glu Thr Val Lys Lys Asn Glu Lys Thr Lys Pro Ser Glu Gly 
             20                  25                  30
Thr Val Lys Gly Lys Lys Gly Val Lys Val Ala Lys Val Asn Asn Pro 
         35                  40                  45
Cys Lys Glu Asp Ala Ser Arg Pro Lys Gln His Thr Glu Lys Arg Gly 
     50                  55                  60
Ser Ser Met Thr Gln Ile Gln Asn Gln Arg Arg His Val Gln Val Lys 
 65                  70                  75                  80
Asp Ala Lys Lys Lys Ser Glu Lys Leu Pro Arg Val Leu Val Asn Leu 
                 85                  90                  95
Val Asn Leu Ser Glu Gly Ser Ser Leu Pro His Ile Ser Glu Thr Asp 
             100                105                110
Glu Asp Ala Val Thr Phe Tyr Val Lys Arg Gln Pro Pro Asn Gln Lys 
         115                120                125
Arg Met Glu Tyr Leu Arg Asn Ser Tyr Leu Gly Ala Ser Asn Val Lys 
     130                135                140
Lys Asn Glu Glu Asn Thr Lys Thr Lys Ser Lys Pro Leu Ser Pro Ile 
 145                150                155                160
Lys Leu Thr Pro Thr Ser Val Leu Asp Tyr Phe Gly Thr Glu Ser Val 
                 165                170                175
Gln Arg Ser Gly Lys Lys Met Val Ala Ser Lys Lys Lys Glu Ser Ser 
             180                185                190
Gln Thr Pro Asp Asp Ser Arg Leu Asn Asp Glu Ala Ile Ala Lys Gln 
         195                200                205
Leu Gln Leu Asp Glu Asp Ala Glu Leu Glu Arg Gln Leu His Glu Asp 
     210                215                220
Glu Glu Phe Ala Arg Thr Leu Ala Leu Leu Asp Glu Glu Pro Lys Thr 
 225                230                235                240
Lys Lys Ala Arg Lys Asp Ser Glu Glu Gly Glu Ser Phe Ser Pro Ala 
                 245                250                255
Lys Ala Glu Leu Ser Lys Ala Ala Lys Gln Lys Ser Pro Ala Asn Glu 
             260                265                270
His Phe Ser Ile Gly Arg Lys Thr Tyr Ser Pro Ala Lys Tyr Gly Lys 
         275                280                285
Gly Arg Gly Ser Glu Gly Thr Lys Gln Pro Cys Arg Ser Ala His Gln 
     290                295                300
Thr Glu Ala Cys Ser Ser Leu Lys Ala Ser Ser Lys Leu Ala Leu Met 
 305                310                315                320
Lys Ala Gln Glu Glu Asn Ser His Thr Asp Thr Glu Leu Leu Ala Ala 
                 325                330                335
Lys Arg Glu Ser Ala Ile Glu Pro Lys Gly Glu Lys Thr Thr Pro Arg 
             340                345                350
Lys Thr Lys Gly Ser Pro Thr Lys Arg Glu Ser Val Ser Pro Glu Asp 
         355                360                365
Ser Glu Lys Lys Arg Thr Asn Tyr Gln Ala Tyr Arg Ser Tyr Leu Asn 
     370                375                380
Arg Glu Gly Pro Lys Ala Leu Gly Ser Lys Glu Ile Pro Lys Gly Ala 
 385                390                395                400
Glu Asn Cys Leu Glu Gly Leu Thr Phe Val Ile Thr Gly Val Leu Glu 
                 405                410                415
Ser Ile Glu Arg Glu Glu Ala Lys Ser Leu Ile Glu Arg Tyr Gly Gly 
             420                425                430
Lys Val Thr Gly Asn Val Ser Lys Lys Thr Ser Tyr Leu Val Met Gly 
         435                440                445
Arg Asp Ser Arg Gln Ser Lys Ser Asp Lys Ala Ala Ala Leu Gly Thr 
     450                455                460
Lys Ile Leu Asp Glu Asp Gly Leu Leu Asp Leu Ile Arg Thr Met Pro 
 465                470                475                480
Gly Lys Lys Ser Lys Tyr Glu Ile Ala Ala Glu Ala Glu Met Lys Lys 
                 485                490                495
Glu Lys Ser Lys Leu Glu Arg Thr Pro Gln Lys Asn Asp Gln Gly Lys 
             500                505                510
Arg Lys Leu Ser Pro Thr Lys Arg Glu Leu Glu Pro Lys Lys Ser Lys 
         515                520                525
Leu Thr Pro Leu Lys His Ser Pro Arg Lys Ala Val Lys Glu Glu Glu 
     530                535                540
Arg Val Cys Pro Arg Gly Leu Asp Ala Lys Glu Pro His Gly Ser His 
 545                550                555                560
Ser Ala Ser Arg Glu Glu Cys Leu Leu Trp Val Asp Lys Tyr Lys Pro 
                 565                570                575
Thr Ser Leu Lys Asn Ile Ile Gly Gln Gln Gly Asp Gln Ser Cys Ala 
             580                585                590
Asn Lys Leu Leu Arg Trp Leu Arg Asn Trp His Lys Ser Ser Pro Glu 
         595                600                605
Glu Lys Lys His Ala Lys Phe Gly Lys Val Ala Ser Lys Asp Asp Gly 
     610                615                620
Ser Ser Phe Lys Ala Ala Leu Leu Ser Gly Pro Pro Gly Val Gly Lys 
 625                630                635                640
Thr Thr Thr Ala Ser Leu Val Cys Gln Glu Leu Gly Tyr Ser Tyr Val 
                 645                650                655
Glu Leu Asn Ala Ser Asp Thr Arg Ser Lys Asn Ser Leu Lys Ala Ile 
             660                665                670
Val Ala Glu Ser Leu Asn Asn Thr Ser Ile Lys Gly Phe Tyr Thr Ser 
         675                680                685
Gly Ala Ser Pro Ser Val Ser Ala Arg His Ala Leu Ile Met Asp Glu 
     690                695                700
Val Asp Gly Met Ala Gly Asn Glu Asp Arg Gly Gly Ile Gln Glu Leu 
 705                710                715                720
Ile Gly Leu Ile Lys His Thr Lys Ile Pro Ile Ile Cys Met Cys Asn 
                 725                730                735
Asp Arg Asn His Pro Lys Ile Arg Ser Leu Val His Tyr Cys Phe Asp 
             740                745                750
Leu Arg Phe Gln Arg Pro Arg Val Glu Gln Ile Lys Ser Ala Met Leu 
         755                760                765
Ser Ile Ala Phe Lys Glu Gly Leu Lys Ile Pro Pro Pro Ala Met Asn 
     770                775                780
Glu Ile Ile Leu Gly Ala Asn Gln Asp Val Arg Gln Val Leu His Asn 
 785                790                795                800
Leu Ser Met Trp Cys Ala Gln Ser Lys Val Leu Thr Tyr Asp Gln Ala 
                 805                810                815
Lys Ala Asp Ser Gln Arg Ala Lys Lys Asp Ile Arg Leu Gly Pro Phe 
             820                825                830
Asp Val Thr Arg Lys Val Phe Ala Ala Gly Glu Glu Thr Pro His Met 
         835                840                845
Ser Leu Met Asp Lys Ser Asp Leu Phe Phe His Asp Tyr Ser Ile Ala 
     850                855                860
Pro Leu Phe Val Gln Glu Asn Tyr Leu His Val Lys Pro Val Ala Ala 
 865                870                875                880
Gly Gly Asp Met Lys Lys His Leu Met Leu Leu Ser Arg Ala Ala Asp 
                 885                890                895
Ser Ile Cys Asp Gly Asp Leu Val Ala Asn Gln Ile Arg Ser Lys Gln 
             900                905                910
Asn Trp Ser Leu Ser His Thr Gly His Leu Arg Gln Arg Cys Ser Trp 
         915                920                925
Arg Val Asp Glu Gly Leu His Val Ser Val Ser Gln Leu Pro Lys Ala 
     930                935                940
Gly Trp Glu Ser Thr Arg Leu Trp Ala Ser Thr Asp Arg Thr Val Gln 
 945                950                955                960
Asp Leu Ser Leu His Met Ser Leu Arg Thr Tyr Ser Ser Lys Arg Thr 
                 965                970                975
Val Asn Met Asp Tyr Leu Ser His Ile Arg Asp Ala Leu Val Arg Pro 
             980                985                990
Leu Thr Ser Gln Gly Val Glu Gly Val Gln Arg Val Val Thr Leu Met 
         995                1000                1005
Leu Val Lys Glu Asp Phe Asp Asn Ile Met Glu Val Ser Ser Asp Thr 
     1010                1015                1020
Tyr Tyr Trp Gly Gly Lys Pro Ser Thr Phe Ser Lys Leu Asp Pro Lys 
 1025                1030                1035                1040
Val Lys Ala Ala Phe Thr Arg Ala Tyr Asn Lys Glu Ala His Leu Thr 
                 1045                1050                1055
Pro Tyr Ser Leu Gln Val Val Lys Ala Ser Arg Pro Ser Ile Gly Pro 
             1060                1065                1070
Ala Leu Asp Ser Glu Tyr Asn Glu Glu Ser Gln Glu Asp Ala Thr Gln 
         1075                1080                1085
Ser Asp Glu Lys Glu Gln Asp Ala Leu Glu Thr Asp Ala Met Ile Lys 
     1090                1095                1100



<210> 612
<211> 4952
<212> DNA
<213> Homo sapiens
<308> L23320
<400> 612

tcagtctgg  actcttttt  gaatgttgt  aaaactagt  aattggaag  taacggtac  60
atttatact  aaagagtac  agactgtct  cgccttctt  cacttcgcg  gagaagttg  120
tggcgcgaa  ggatcctga  cctcgataa  agattcctc  accggccca  ccgccagcc  180
gccagcgcc  tcatcctgg  gctgcgatg  acattcgga  attctttgg  gtaatacca  240
gtggaaaga  acttgtaag  gaaacagta  agaagaatg  gaaaacaaa  tctgatgaa  300
aaactttaa  agcaaagaa  ggaataaag  aaatcaagg  aaatagctc  cgtaaagag  360
atgacttca  acaaaagca  ccaagcaag  aaaagagga  catctatga  tcagattca  420
agtcagagg  gacgttgca  gtaaaaaat  ccaaaaagc  accagaaaa  ctgccagta  480
cttctaaac  tggtaaaat  tcacggcag  atcctgtta  atacatttc  gaaacagat  540
aagaagatg  ctttatgtg  aagaaggcg  cctctaaat  aaaagagaa  ggaagatct  600
caaatagtc  tcttggaac  tcaaacatg  aaaagaatg  agaaaacac  aagaccaag  660
ataagcctt  atcaccaat  aaacttaca  ccacatcag  acttgatta  tttggaact  720
gaagtgtcc  aagatctaa  aagaagatg  tggcaagca  aagaaaaga  ctttcacaa  780
atacagatg  gtctggatt  aatgatgaa  ccatcgcca  gcaattaca  cttgatgaa  840
atgcggagc  ggagaggca  ttgcatgaa  atgaagagt  tgccagaac  ttagccatg  900
tggatgaag  acccaagac  aaaaaggct  gaaaggaca  agaagcggg  gaaacgttt  960
catctgtcc  agccaattt  agtaaagca  aaaaacata  atatcctca  aaagtaaaa  1020
cagcacaag  ttcagatga  agaaagagc  acagtccta  gaagcaaag  aaatatgaa  1080
gttcaaaag  atctcagca  cattccaag  catcagctg  caaaatagg  gaagtctct  1140
ctcccaagg  cagttctaa  ctggcaatt  tgaaaagaa  aaaagagag  tcttataaa  1200
aaatagagc  tgtggcctc  aaaagaaaa  aaaatgcca  taaattgaa  ggagagaca  1260
aaactccta  gaaaaccaa  agttctcca  ctaaaaaag  gtctgtaag  cctgaagat  1320
ctgaaaaga  acgcactaa  tatcaagct  atcgaagct  cttaaatcg  gaaggtccc  1380
aggctctgg  ctccaaaga  ataccaaag  gagctgaaa  ttgcttgga  ggccttata  1440
ttgtaatca  aggcgtgct  gagtctatt  aacgagatg  ggccaagtc  ctaattgaa  1500
gttatgggg  aaaagtaac  ggaaatgtc  gcaagaaaa  aaattatct  gtcatgggt  1560
gtgatagtg  acagtccaa  agtgataag  ccgcagcct  ggggacaaa  attattgat  1620
aagatggcc  gttgaatct  attcggact  tgccaggca  gaaatccaa  tatgaaata  1680
cagttgaaa  tgagatgaa  aaagagtcc  aactggaga  aacacccca  aaaaatgtc  1740
aaggaaaaa  aaaaattag  ccatctaaa  aggaatcag  atctaaaaa  agcaggccg  1800
cttccaaaa  ggacagttt  gcaaagaca  taaaaaagg  aacagatgt  ttttggaaa  1860
gcctggatt  caaggagca  gtggctgag  agacaagtg  tgacagcaa  gctaggaat  1920
tggctgatg  cagcagtga  aacaaagtg  aaaatttgc  ctgggtgga  aaatataag  1980
caacctcgc  caagaccat  attggacag  aaggtgacc  gagctgtgc  aacaaactc  2040
tacgctggc  ccgaaactg  caaaagagt  cttccgaag  taaaaaaca  gcagcaaag  2100
ttggtaaat  ttccggcaa  gatgatggc  ctagtttta  agcagcgtt  ctgtcaggc  2160
ctcctggtg  tggcaaaac  accacagct  ccctggtgt  tcaggagtt  ggatacagc  2220
acgtggaac  gaatgcaag  gacacccgg  gtaagagca  tttgaaagc  attgttgct  2280
agtcactga  caataccag  atcaaaggc  tttattcaa  tggagcagc  tcttcagta  2340
gcacgaaac  tgctctcat  atggatgaa  tagatggca  ggcaggcaa  gaggatagg  2400
gaggaattc  ggaattaat  ggcctgata  aacatacta  aattcccat  atttgtatg  2460
gcaatgata  aaatcatcc  aagattcgc  ctctggttc  ttattgttt  gatcttcgt  2520
ttcaaagac  tcgggttga  cagattaag  gtgctatga  gtctattgc  tttaaagaa  2580
gtttaaaga  tccccctcc  gctatgaat  aaataattt  gggagccaa  caagatatc  2640
gacaggttt  acataatct  agtatgtgg  gtgcacgaa  taaagcatt  acctatgac  2700
aggccaaag  tgattctca  agagccaaa  aggatatca  aatgggccc  tttgatgtt  2760
cccggaaag  gtttgcagc  ggagaggag  ctgctcaca  gtcacttgt  gacaagtca  2820
atctctttt  tcatgatta  tcaatagca  ccctcttcg  ccaggaaaa  tacatacac  2880
tgaagcctg  agcagcagg  ggtgacatg  aaaagcacc  gatgctttt  agcagagca  2940
cagacagca  atgcgatgg  gacctagtg  acagccaga  ccggagtaa  caaaactgg  3000
gtcttctgc  tgcgcaggc  atttatgcc  gtgttcttc  tggagagtt  atgaggggg  3060
acatgaccc  gtttcccac  ttcccaagc  ggctgggga  gcactcgtc  acaggcaaa  3120
atgatcgta  tgttcagga  ctggccttg  atatgagtc  cagaactta  tccagcaaa  3180
ggactgtaa  catggatta  ctgtcgctt  taagggatg  acttgtaca  cccttgacc  3240
cacaaggag  agacggagt  caggatgtt  ttgcactta  ggacacata  tatttgatg  3300
aagaagact  tgagaatat  atggaaatc  gcagctggg  tggcaaacc  agtcccttt  3360
caaagctgg  tcccaaggt  aaagcagcc  tcacaagag  ttacaataa  gaagcccac  3420
ttactccat  ctcacttca  gctataaag  catctagac  cagcacaag  ccatccctg  3480
attcggaat  caatgaaga  ttaaatgaa  atgactctc  atctgatga  aaagaccaa  3540
atgctatag  aactgatgc  atgatcaag  aaaagacaa  atcttcaaa  ccttcaaaa  3600
cagaaaaag  taaggagcc  agaaaagga  aaggaaaaa  ttcgaagaa  tgaaaccat  3660
tttcactag  gacagccac  ttttactct  cctcctgac  agtccagct  gtctagaga  3720
agccttgtt  tttcccaga  caaccatgt  ttagcataa  gggatgacc  ggtgtccca  3780
tataaataa  gggtggtat  gctagaagg  tatgagcag  aggcttatg  acacctctt  3840
tagaggttg  taggactgc  tgggtcctc  actgtcctc  gtcaatcta  ttagacgtg  3900
ttctgaatg  ctgtagaat  ggaactaga  actacacct  ggctttgga  tcagatttt  3960
gttaacaat  atgagcctg  agcagtagt  ctaaggcgt  ttttgtagg  ttaagaatt  4020
atcctaatg  cctttatag  accaatgct  atttttttt  aaggcagtt  ctattatgt  4080
gtgaaattt  gtaaataaa  gattataca  aacagtcac  acctagaac  gggtattct  4140
tgtacattg  cagatatct  tcaaagtat  aattaggaa  aaaaatgtt  cacatgata  4200
gtgtacaaa  tctttttaa  attgtcatc  tgtacagca  aatattatg  tggtatatt  4260
cttccttat  aatttgcaa  tgattggat  aaaaaagct  actgtattc  ttactaacc  4320
gttgtgtga  acataacat  ggcagtcga  gagtcagaa  tcggattcc  agcctcact  4380
cctctgtgt  tgttgacca  gtctctgct  tgaatagga  ttcatgcag  ggtctgtta  4440
ggggctttg  agcgtgggg  gctgcagaa  attctcaga  attcttatc  ttctggagt  4500
tcaacccat  aggttcaga  cagtaggaa  caggctggg  caggctctt  atttcacta  4560
ggtggggga  aaaatgaac  ctggctttt  ttcactttg  ccctgagag  tctagtcct  4620
tcctgtgat  gcttccaca  accctgttg  aagtttggg  tattcctat  actgtatgt  4680
ttgagtggc  gtgacgtat  gacctagcc  ggaatttag  tgtctagct  ttttttaat  4740
ttgttggta  atgctcaga  gtctgtgct  cctctgtga  gtatatact  aaatgaatg  4800
aaaataagg  tcgtattcc  tgctttaag  aactggtag  cttgtttgg  tgatgagac  4860
aagttcttg  gacatttaa  ctgtattta  cagtgtgaa  aatgtcatt  atggagatt  4920
attcattat  gaaataaaa  attgcctaa  ca  4952



<210> 613
<211> 1147
<212> PRT
<213> Homo sapiens
<308> AAA16121
<400> 613

Met Asp Ile Arg Lys Phe Phe Gly Val Ile Pro Ser Gly Lys Lys Leu 
  1               5                  10                  15
Val Ser Glu Thr Val Lys Lys Asn Glu Lys Thr Lys Ser Asp Glu Glu 
             20                  25                  30
Thr Leu Lys Ala Lys Lys Gly Ile Lys Glu Ile Lys Val Asn Ser Ser 
         35                  40                  45
Arg Lys Glu Asp Asp Phe Lys Gln Lys Gln Pro Ser Lys Lys Lys Arg 
     50                  55                  60
Ile Ile Tyr Asp Ser Asp Ser Glu Ser Glu Glu Thr Leu Gln Val Lys 
 65                  70                  75                  80
Asn Ala Lys Lys Pro Pro Glu Lys Leu Pro Val Ser Ser Lys Pro Gly 
                 85                  90                  95
Lys Ile Ser Arg Gln Asp Pro Val Thr Tyr Ile Ser Glu Thr Asp Glu 
             100                105                110
Glu Asp Asp Phe Met Cys Lys Lys Ala Ala Ser Lys Ser Lys Glu Asn 
         115                120                125
Gly Arg Ser Thr Asn Ser His Leu Gly Thr Ser Asn Met Lys Lys Asn 
     130                135                140
Glu Glu Asn Thr Lys Thr Lys Asn Lys Pro Leu Ser Pro Ile Lys Leu 
 145                150                155                160
Thr Pro Thr Ser Val Leu Asp Tyr Phe Gly Thr Gly Ser Val Gln Arg 
                 165                170                175
Ser Asn Lys Lys Met Val Ala Ser Lys Arg Lys Glu Leu Ser Gln Asn 
             180                185                190
Thr Asp Glu Ser Gly Leu Asn Asp Glu Ala Ile Ala Lys Gln Leu Gln 
         195                200                205
Leu Asp Glu Asp Ala Glu Leu Glu Arg Gln Leu His Glu Asp Glu Glu 
     210                215                220
Phe Ala Arg Thr Leu Ala Met Leu Asp Glu Glu Pro Lys Thr Lys Lys 
 225                230                235                240
Ala Arg Lys Asp Thr Glu Ala Gly Glu Thr Phe Ser Ser Val Gln Ala 
                 245                250                255
Asn Leu Ser Lys Ala Glu Lys His Lys Tyr Pro His Lys Val Lys Thr 
             260                265                270
Ala Gln Val Ser Asp Glu Arg Lys Ser Tyr Ser Pro Arg Lys Gln Ser 
         275                280                285
Lys Tyr Glu Ser Ser Lys Glu Ser Gln Gln His Ser Lys Ser Ser Ala 
     290                295                300
Asp Lys Ile Gly Glu Val Ser Ser Pro Lys Ala Ser Ser Lys Leu Ala 
 305                310                315                320
Ile Met Lys Arg Lys Glu Glu Ser Ser Tyr Lys Glu Ile Glu Pro Val 
                 325                330                335
Ala Ser Lys Arg Lys Glu Asn Ala Ile Lys Leu Lys Gly Glu Thr Lys 
             340                345                350
Thr Pro Lys Lys Thr Lys Ser Ser Pro Ala Lys Lys Glu Ser Val Ser 
         355                360                365
Pro Glu Asp Ser Glu Lys Lys Arg Thr Asn Tyr Gln Ala Tyr Arg Ser 
     370                375                380
Tyr Leu Asn Arg Glu Gly Pro Lys Ala Leu Gly Ser Lys Glu Ile Pro 
 385                390                395                400
Lys Gly Ala Glu Asn Cys Leu Glu Gly Leu Ile Phe Val Ile Thr Gly 
                 405                410                415
Val Leu Glu Ser Ile Glu Arg Asp Glu Ala Lys Ser Leu Ile Glu Arg 
             420                425                430
Tyr Gly Gly Lys Val Thr Gly Asn Val Ser Lys Lys Thr Asn Tyr Leu 
         435                440                445
Val Met Gly Arg Asp Ser Gly Gln Ser Lys Ser Asp Lys Ala Ala Ala 
     450                455                460
Leu Gly Thr Lys Ile Ile Asp Glu Asp Gly Leu Leu Asn Leu Ile Arg 
 465                470                475                480
Thr Met Pro Gly Lys Lys Ser Lys Tyr Glu Ile Ala Val Glu Thr Glu 
                 485                490                495
Met Lys Lys Glu Ser Lys Leu Glu Arg Thr Pro Gln Lys Asn Val Gln 
             500                505                510
Gly Lys Arg Lys Ile Ser Pro Ser Lys Lys Glu Ser Glu Ser Lys Lys 
         515                520                525
Ser Arg Pro Thr Ser Lys Arg Asp Ser Leu Ala Lys Thr Ile Lys Lys 
     530                535                540
Glu Thr Asp Val Phe Trp Lys Ser Leu Asp Phe Lys Glu Gln Val Ala 
 545                550                555                560
Glu Glu Thr Ser Gly Asp Ser Lys Ala Arg Asn Leu Ala Asp Asp Ser 
                 565                570                575
Ser Glu Asn Lys Val Glu Asn Leu Leu Trp Val Asp Lys Tyr Lys Pro 
             580                585                590
Thr Ser Leu Lys Thr Ile Ile Gly Gln Gln Gly Asp Gln Ser Cys Ala 
         595                600                605
Asn Lys Leu Leu Leu Trp Leu Arg Asn Trp Gln Lys Ser Ser Ser Glu 
     610                615                620
Asp Lys Lys His Ser Lys Phe Gly Lys Phe Ser Gly Lys Asp Asp Asn 
 625                630                635                640
Ser Ser Phe Lys Ala Ala Leu Leu Ser Gly Pro Pro Gly Val Gly Lys 
                 645                650                655
Thr Thr Thr Ala Ser Leu Val Cys Gln Glu Leu Gly Tyr Ser Tyr Val 
             660                665                670
Glu Leu Asn Arg Ser Asp Thr Arg Ser Lys Ser Ser Leu Lys Ala Ile 
         675                680                685
Val Ala Glu Ser Leu Asn Asn Thr Ser Ile Lys Gly Phe Tyr Ser Asn 
     690                695                700
Gly Ala Ala Ser Ser Val Ser Thr Lys His Ala Leu Ile Met Asp Glu 
 705                710                715                720
Val Asp Gly Met Ala Gly Asn Glu Asp Arg Gly Gly Ile Gln Glu Leu 
                 725                730                735
Ile Gly Leu Ile Lys His Thr Lys Ile Pro Ile Ile Cys Met Cys Asn 
             740                745                750
Asp Arg Asn His Pro Lys Ile Arg Ser Leu Val His Tyr Cys Phe Asp 
         755                760                765
Leu Arg Phe Gln Arg Pro Arg Val Glu Gln Ile Lys Gly Ala Met Met 
     770                775                780
Ser Ile Ala Phe Lys Glu Gly Leu Lys Ile Pro Pro Pro Ala Met Asn 
 785                790                795                800
Glu Ile Ile Leu Gly Ala Asn Gln Asp Ile Arg Gln Val Leu His Asn 
                 805                810                815
Leu Ser Met Trp Cys Ala Arg Ser Lys Ala Leu Thr Tyr Asp Gln Ala 
             820                825                830
Lys Ala Asp Ser His Arg Ala Lys Lys Asp Ile Lys Met Gly Pro Phe 
         835                840                845
Asp Val Ala Arg Lys Val Phe Ala Ala Gly Glu Glu Thr Ala His Met 
     850                855                860
Ser Leu Val Asp Lys Ser Asp Leu Phe Phe His Asp Tyr Ser Ile Ala 
 865                870                875                880
Pro Leu Phe Val Gln Glu Asn Tyr Ile His Val Lys Pro Val Ala Ala 
                 885                890                895
Gly Gly Asp Met Lys Lys His Leu Met Leu Leu Ser Arg Ala Ala Asp 
             900                905                910
Ser Ile Cys Asp Gly Asp Leu Val Asp Ser Gln Ile Arg Ser Lys Gln 
         915                920                925
Asn Trp Ser Leu Leu Pro Ala Gln Ala Ile Tyr Ala Ser Val Leu Pro 
     930                935                940
Gly Glu Leu Met Arg Gly Tyr Met Thr Gln Phe Pro Thr Phe Pro Ser 
 945                950                955                960
Trp Leu Gly Lys His Ser Ser Thr Gly Lys His Asp Arg Ile Val Gln 
                 965                970                975
Asp Leu Ala Leu His Met Ser Leu Arg Thr Tyr Ser Ser Lys Arg Thr 
             980                985                990
Val Asn Met Asp Tyr Leu Ser Leu Leu Arg Asp Ala Leu Val Gln Pro 
         995                1000                1005
Leu Thr Ser Gln Gly Val Asp Gly Val Gln Asp Val Val Ala Leu Met 
     1010                1015                1020
Asp Thr Tyr Tyr Leu Met Lys Glu Asp Phe Glu Asn Ile Met Glu Ile 
 1025                1030                1035                1040
Ser Ser Trp Gly Gly Lys Pro Ser Pro Phe Ser Lys Leu Asp Pro Lys 
                 1045                1050                1055
Val Lys Ala Ala Phe Thr Arg Ala Tyr Asn Lys Glu Ala His Leu Thr 
             1060                1065                1070
Pro Tyr Ala Leu Gln Ala Ile Lys Ala Ser Arg His Ser Thr Ser Pro 
         1075                1080                1085
Ser Leu Asp Ser Glu Tyr Asn Glu Glu Leu Asn Glu Asp Asp Ser Gln 
     1090                1095                1100
Ser Asp Glu Lys Asp Gln Asp Ala Ile Glu Thr Asp Ala Met Ile Lys 
 1105                1110                1115                1120
Lys Lys Thr Lys Ser Ser Lys Pro Ser Lys Pro Glu Lys Asp Lys Glu 
                 1125                1130                1135
Pro Arg Lys Gly Lys Gly Lys Ser Ser Lys Lys 
             1140                1145



<210> 614
<211> 816
<212> DNA
<213> Rattus norvegicus
<308> AF030087
<400> 614

gttgtgcta  attaaagtt  cagagctca  tagattgag  ttgtaatgt  tgtcatgta  60
gcatgcatt  ctgtaacag  catgcatca  cttttacat  agtacgctt  tgtgactcg  120
tgagaaaac  caggaaaga  agattgtaa  tccaaatca  gtcttccac  ttgctcttc  180
atatttctt  accacttag  aaaaaagct  acaagcctt  gaagaaaca  cagcaggct  240
ttatttttt  caaggttta  aaattaagt  cttgatttt  aatgtattc  cgctactgt  300
ttgattttc  gatcttgat  caatatttg  agatgtgcc  tttattggg  aatgttaat  360
ctcgaatgt  gtaatgttg  accacaatt  taatgttac  tgatcatgg  tgtggcatt  420
tctgacaaa  tatgtgaca  gaaagtcat  ttcagagaa  tcatggctc  gattgcaca  480
tccccttgc  aaagcaaag  gcactctct  aaggctact  cagaactgg  ctttgtatt  540
tctctaagt  atggatgcg  cgtgtccat  tagaggcag  gtaccacgt  tcccaggca  600
ccctagata  gtgccatga  aaagttcaa  gactaacaa  gtctacagg  actcaaaat  660
tcatttttg  aatggtaac  ccccaagat  ttctccaag  aataaatta  tttgtactt  720
ataacttaa  agcagctag  agtacattt  tgagatata  caggagacc  aaacatttt  780
ggaaaaaga  taaatatat  aagagaaaa  aaaaaa  816



<210> 615
<211> 816
<212> DNA
<213> Rattus norvegicus
<308> AF030087
<400> 615

gttgtgcta  attaaagtt  cagagctca  tagattgag  ttgtaatgt  tgtcatgta  60
gcatgcatt  ctgtaacag  catgcatca  cttttacat  agtacgctt  tgtgactcg  120
tgagaaaac  caggaaaga  agattgtaa  tccaaatca  gtcttccac  ttgctcttc  180
atatttctt  accacttag  aaaaaagct  acaagcctt  gaagaaaca  cagcaggct  240
ttatttttt  caaggttta  aaattaagt  cttgatttt  aatgtattc  cgctactgt  300
ttgattttc  gatcttgat  caatatttg  agatgtgcc  tttattggg  aatgttaat  360
ctcgaatgt  gtaatgttg  accacaatt  taatgttac  tgatcatgg  tgtggcatt  420
tctgacaaa  tatgtgaca  gaaagtcat  ttcagagaa  tcatggctc  gattgcaca  480
tccccttgc  aaagcaaag  gcactctct  aaggctact  cagaactgg  ctttgtatt  540
tctctaagt  atggatgcg  cgtgtccat  tagaggcag  gtaccacgt  tcccaggca  600
ccctagata  gtgccatga  aaagttcaa  gactaacaa  gtctacagg  actcaaaat  660
tcatttttg  aatggtaac  ccccaagat  ttctccaag  aataaatta  tttgtactt  720
ataacttaa  agcagctag  agtacattt  tgagatata  caggagacc  aaacatttt  780
ggaaaaaga  taaatatat  aagagaaaa  aaaaaa  816



<210> 616
<211> 816
<212> DNA
<213> Rattus norvegicus
<308> AF030087
<400> 616

gttgtgcta  attaaagtt  cagagctca  tagattgag  ttgtaatgt  tgtcatgta  60
gcatgcatt  ctgtaacag  catgcatca  cttttacat  agtacgctt  tgtgactcg  120
tgagaaaac  caggaaaga  agattgtaa  tccaaatca  gtcttccac  ttgctcttc  180
atatttctt  accacttag  aaaaaagct  acaagcctt  gaagaaaca  cagcaggct  240
ttatttttt  caaggttta  aaattaagt  cttgatttt  aatgtattc  cgctactgt  300
ttgattttc  gatcttgat  caatatttg  agatgtgcc  tttattggg  aatgttaat  360
ctcgaatgt  gtaatgttg  accacaatt  taatgttac  tgatcatgg  tgtggcatt  420
tctgacaaa  tatgtgaca  gaaagtcat  ttcagagaa  tcatggctc  gattgcaca  480
tccccttgc  aaagcaaag  gcactctct  aaggctact  cagaactgg  ctttgtatt  540
tctctaagt  atggatgcg  cgtgtccat  tagaggcag  gtaccacgt  tcccaggca  600
ccctagata  gtgccatga  aaagttcaa  gactaacaa  gtctacagg  actcaaaat  660
tcatttttg  aatggtaac  ccccaagat  ttctccaag  aataaatta  tttgtactt  720
ataacttaa  agcagctag  agtacattt  tgagatata  caggagacc  aaacatttt  780
ggaaaaaga  taaatatat  aagagaaaa  aaaaaa  816



<210> 617
<211> 816
<212> DNA
<213> Rattus norvegicus
<308> AF030087
<400> 617

gttgtgcta  attaaagtt  cagagctca  tagattgag  ttgtaatgt  tgtcatgta  60
gcatgcatt  ctgtaacag  catgcatca  cttttacat  agtacgctt  tgtgactcg  120
tgagaaaac  caggaaaga  agattgtaa  tccaaatca  gtcttccac  ttgctcttc  180
atatttctt  accacttag  aaaaaagct  acaagcctt  gaagaaaca  cagcaggct  240
ttatttttt  caaggttta  aaattaagt  cttgatttt  aatgtattc  cgctactgt  300
ttgattttc  gatcttgat  caatatttg  agatgtgcc  tttattggg  aatgttaat  360
ctcgaatgt  gtaatgttg  accacaatt  taatgttac  tgatcatgg  tgtggcatt  420
tctgacaaa  tatgtgaca  gaaagtcat  ttcagagaa  tcatggctc  gattgcaca  480
tccccttgc  aaagcaaag  gcactctct  aaggctact  cagaactgg  ctttgtatt  540
tctctaagt  atggatgcg  cgtgtccat  tagaggcag  gtaccacgt  tcccaggca  600
ccctagata  gtgccatga  aaagttcaa  gactaacaa  gtctacagg  actcaaaat  660
tcatttttg  aatggtaac  ccccaagat  ttctccaag  aataaatta  tttgtactt  720
ataacttaa  agcagctag  agtacattt  tgagatata  caggagacc  aaacatttt  780
ggaaaaaga  taaatatat  aagagaaaa  aaaaaa  816



<210> 618
<211> 4831
<212> DNA
<213> Rattus norvegicus
<308> AF030089
<400> 618

agcccgctc  ccgagcagc  ttagccatc  ctaactaat  caactgctt  ccagtctgc  60
ggtgctggg  tcggtgctg  gaagaggct  tggctcttg  ctattgtca  gtcaaacac  120
aagactgtg  ccatgttag  actcataga  gttaatgga  cccctggca  tcagctctc  180
actccgcgc  ccggcaagt  accaagtcc  tcgcccacc  gcccaggaa  cctgcggaa  240
cagagggac  tgtaccgcc  tctctcgtc  gatgatttg  actcagtag  agactcagt  300
taaaagaca  agtggagcg  tgtgtatgg  ttgtgatgg  atcaaggtt  cccatttcc  360
aagcaagca  ctaacagca  aatacacaa  agagttttg  ataagcaat  aaattatac  420
aaagcaaga  tgcagacat  ttctactcg  cggtattct  tgaaagaaa  aaaaacttt  480
ttaaagcat  tcctccatt  gatgtaacc  aggagagtt  gaatacaat  tttgttcat  540
actgaggat  ttatgacta  ggtctggtt  cagataaat  tcatatatg  ctccaatat  600
aagtacaag  atcacccta  cgatccagc  ttatggagt  accatttct  taaatgagc  660
tgcttttta  tcagtaagt  gatatataa  tacaatttt  ctgtactta  tatctttta  720
ctttttagt  taaattttt  taaaaaaat  agacagcta  ttagttatt  cattgcaaa  780
taacataaa  gaatctctt  aggattttt  atttgagtg  atacgtctg  aggggagtg  840
aggaactcc  taagagacg  ctcccagag  ccaacatta  gcagcgaga  cgtttctgg  900
ttttttttt  ttttttttt  tgtttttgt  ttttgccac  tggattttc  tttcccaga  960
ttttataaa  atagtttca  ctacatgga  acatgaata  cttggcatt  ttattaatt  1020
tataatggt  ccctacagc  acaacagta  atatatctt  ttcaagtgt  taaagtttt  1080
tgacctaaa  caaatggga  ttgtactgt  tttcaaaaa  taaactcag  ttgagaatt  1140
gaattcttc  acacagagc  tgtacgttg  gcctccagg  agctaaact  cattctgat  1200
atcctgcat  ccgttgttt  ggatatctt  acatgcaaa  ctccttttg  gtcaaaccg  1260
gtgtgtcta  gattataac  cactgttaa  attaaccta  taattcttc  cctttagtc  1320
tctactttc  aaagcgtga  tcagctttg  ttaaatgta  aacagttat  ttttaaatc  1380
agatgttag  aatcaatgt  tacggtgta  tgtatttag  ccatacccg  gaccgtttc  1440
ttttactag  tcaaacact  acaatttaa  acttacaaa  catgggttt  atattcgcc  1500
ggcttgaca  atctcagta  ggtgacaga  ttaaaatgt  tggtgccat  tggagcctt  1560
tacttgaga  ttctttcaa  tttcacttg  aaacatttt  aaaatgcct  attcaagat  1620
gagaggagt  gccttgtca  acggtctca  atgttattg  tttatttct  tcagtagac  1680
gttcgacta  caatttttc  catctggtt  atcgttacc  gtgctagca  ctcacttga  1740
aagtgaata  aatattcca  ctgaaaaaa  aaaaataag  cctccaggc  acctaccag  1800
atttgaaaa  ttagccgag  gataattag  gcctcatta  cctgcctgt  agagaggag  1860
gggcacttc  ttggcgtgt  atttgagaa  tgcagactg  tccctccat  ttgaaagca  1920
agagaatga  catacctgt  ccagacttc  gattttaaa  ctgtttcca  tagacacga  1980
cagagactc  tgctgagat  aaagggccg  tttgtcttt  gctgaaaca  taaacatct  2040
ggaggatgc  gtgctgcct  ttggagtgt  acgtctttg  aagatgcat  gcttaatat  2100
gtccaaccc  taaaagatt  gtacagatt  gactaacct  tcaaaaaat  caatgaaag  2160
agtgggtca  atggtccag  acaaaacat  aattccagt  atttcaact  ccctatgaa  2220
tcaatctta  ggacgacta  tgctaggag  aacctaata  atgttatct  ctataaaaa  2280
cgtggcttt  tttagacac  gcatagagt  gacttggac  aattgccag  aggtattgt  2340
gccaacttt  cattcaagc  gttccagag  gatgcaatc  catggcatt  catcctgga  2400
catacgatt  ttattaaag  attgttcaa  ggccatata  ctcatttac  tttgaaact  2460
aagtccctc  gagattgaa  caacacacc  tgagatctc  ttctatgca  ggaataatt  2520
tattatcca  aagcagagt  tttgaacat  caagcagcc  accaggtca  tagtaaaga  2580
ccaatgggc  attagcagt  actcaagac  tggctgctt  tagaatcct  ctaacatca  2640
tagtcgctg  actctaaaa  tgaccttct  aggagagag  tccagccaa  aaaagccac  2700
tgcttttct  tcactgata  agcctctgc  gtgttgacc  ttcaggcct  tgcatgtat  2760
gttacattt  tttagacat  cctagaaag  aagatgcta  aaagagtcc  ctgctttca  2820
cattttatg  gctaaaacc  tagtgatgc  caaaatgtg  tgctctgcg  gaactccga  2880
gccatgtgg  aaagtcatt  tcatttcag  agaaggtct  tactcttgt  ggtttctaa  2940
ccggaagtt  gtgctccac  tatatgtac  catgcctgc  atgcacaca  gaggtcacc  3000
taacatgtc  agatctgat  ccgttgtct  ccaacccca  agcagctct  acacctatg  3060
tcccctgcc  agcagcgag  gcactcgcc  tccccttcc  tgcagccgc  ccgagctgt  3120
cttttgttt  catttaaaa  aactgaatt  caaaagcct  gttttaaaa  agcaattgg  3180
aatgaaaat  cataagaat  atcctaaaa  ataaatcca  atatttaac  tgttgaact  3240
ctaggtttt  tttttcttt  cctggtggc  atatatcta  acaggtgtg  aggtgtgcc  3300
acataaata  ctgtgtttg  atatagaac  tgaagaata  aggatgata  ttgtgatat  3360
gtcttataa  ttactggct  ctgtagaat  aactgtgaa  ctttatgtg  taaagttgt  3420
acgtatgta  tagttggca  atgtttaag  tcaaaacaa  ttggctaaa  tatcatgaa  3480
cagtaccaa  tgttcacgg  tacgaattt  tccaagacc  attggaatc  agacaaaca  3540
aaaaattga  gtccaagca  atccaatct  acagtgatt  ataaatgta  atactcatt  3600
atgttttca  tgtaaattc  tgatgctca  ccagtaatc  gacagaatg  agtgacact  3660
tcctgttgt  tgtgtactg  tgactacag  gattatcaa  gggaaattc  ccaaacaaa  3720
tgatttcta  acttgtgga  agttgagtg  tgtgctgaa  taaaagtag  aaaggtcaa  3780
gtaaattcg  tttgaagcc  tgttatgaa  ccagacaac  tgtaaggcc  tgctgtgtg  3840
cctttttat  aactgtttt  gagacactt  ctgtgtgtg  gcatgtgtg  ctacatgag  3900
gtatacaca  ttgaaaatg  ttattgact  aagttcact  tctgtatac  tctgtgcct  3960
tctgcattg  tctggccag  gcctctaac  gtgcatggt  gtgacagcc  tgtgtgatt  4020
gatgaaccc  cagaaaaat  gtgtggaaa  cagagctgc  tcaaactca  tataacaat  4080
gcctgatat  gcatattaa  ttgtcagct  aaaaacgtt  gtaatgttg  gcctgtaac  4140
tgtgtaggg  aaactggaa  atctgaggc  ctcactata  ttttaaggg  gcatgacat  4200
tggtgtctt  aaagatgta  cttattgta  taaaaggtg  tggataaat  ctgaggtag  4260
gtaagtgaa  catgaaacg  taggtgttt  tattatata  ggccacaca  tatttttga  4320
ggcagggta  taaatgttt  aaggttaat  ggcaaagaa  atggaagtt  attttactg  4380
gatgtgttt  tgaggtgtt  ttacacatt  ccagacaag  aacttagtt  ctgtttccc  4440
cctgtggac  ctttgaaac  ctatgaatg  tacaaagtt  gattttctt  ataaaggtc  4500
caaaccatt  gcagttgga  ttgcttgga  gtatagtct  ctctttggg  aaaaaaacc  4560
ctttggtat  aaaatggtt  aagcactaa  acattggga  atacgtcgt  tgaggccat  4620
tgcagacat  tgtagagat  agaactaat  aaatgtgtt  ctgaactac  cagttttga  4680
agcttccat  cctctctgc  gtagtctcc  cgaaaatgc  gtaccttgt  tttcacatg  4740
aaccatgtt  ctctctccc  aacttacct  tgtgacact  agcagctta  ccaaaccac  4800
taataaaca  gaagaactg  aaaaaaaaa  a  4831



<210> 619
<211> 56
<212> PRT
<213> Rattus norvegicus
<308> AAD43824
<400> 619

Met Leu Glu Leu Ile Glu Val Asn Gly Thr Pro Gly Ser Gln Leu Ser 
  1               5                  10                  15
Thr Pro Arg Ser Gly Lys Ser Pro Ser Pro Ser Pro Thr Ser Pro Gly 
             20                  25                  30
Ser Leu Arg Lys Gln Arg Asp Leu Tyr Arg Pro Leu Ser Ser Asp Asp 
         35                  40                  45
Leu Asp Ser Val Gly Asp Ser Val 
     50                  55



<210> 620
<211> 861
<212> DNA
<213> Homo sapiens
<308> BI598343
<400> 620

agcgggagc  ttagccatc  ttaaactca  ccaaccgat  cccatttcc  cgggtgctt  60
gcttagtgc  gagacggga  tccgccgtt  gtattcagg  ccaacacta  gactgtgtc  120
atgttagaa  tcatagaag  taatggaac  cctggtagt  agctctcta  tccgcgctc  180
ggcaagtcg  caagcccat  acccaccag  ccaggaagc  tgcggaagc  gaggagctc  240
cagcatggc  gctcctcta  gtcacttgc  tccaccaaa  tctgcagct  gatggatga  300
aacgatggc  ctggagaag  agtgtcgga  gaaggcttc  agattccag  tacaataac  360
gaacgatat  aagtcggaa  aacaatagg  gatggaaat  ttgctgttg  caaggaatg  420
gtagaaaga  cgactgcta  agagtacgc  ctgaaaatt  tcaagaaaa  caaatgtcg  480
ggcaaagag  acatgatcc  gaatgaagt  tctatttta  gaagagtga  gcatcccaa  540
atcgttctt  tgattgagg  gatggatgt  ccaactgaa  tgtatcttg  catggaatt  600
gtaaacggg  ggagacctt  ttgatgcca  tacttccac  aacaaatac  ccgagagag  660
cgccagtgg  atgctgtac  acctaagcc  gcgccatca  tacctggca  aggcctgaa  720
atcgtccac  gtggattcc  gccagagaa  cctgctggt  ttattgagc  ccagaatgg  780
agcaaatca  tgaagctgt  tgaccttgg  actggcccc  attgttcaa  cggcccctg  840
aacacacgt  ctgtggacc  g  861



<210> 621
<211> 740
<212> PRT
<213> Homo sapiens
<308> O15075
<400> 621

Met Ser Phe Gly Arg Asp Met Glu Leu Glu His Phe Asp Glu Arg Asp 
  1               5                  10                  15
Lys Ala Gln Arg Tyr Ser Arg Gly Ser Arg Val Asn Gly Leu Pro Ser 
             20                  25                  30
Pro Thr His Ser Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln 
         35                  40                  45
Thr Leu Ser Ser Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn 
     50                  55                  60
Gly Asp Arg Tyr Phe Lys Gly Ile Val Tyr Ala Ile Ser Pro Asp Arg 
 65                  70                  75                  80
Phe Arg Ser Phe Glu Ala Leu Leu Ala Asp Leu Thr Arg Thr Leu Ser 
                 85                  90                  95
Asp Asn Val Asn Leu Pro Gln Gly Val Arg Thr Ile Tyr Thr Ile Asp 
             100                105                110
Gly Leu Lys Lys Ile Ser Ser Leu Asp Gln Leu Val Glu Gly Glu Ser 
         115                120                125
Tyr Val Cys Gly Ser Ile Glu Pro Phe Lys Lys Leu Glu Tyr Thr Lys 
     130                135                140
Asn Val Asn Pro Asn Trp Ser Val Asn Val Lys Thr Thr Ser Ala Ser 
 145                150                155                160
Arg Ala Val Ser Ser Leu Ala Thr Ala Lys Gly Ser Pro Ser Glu Val 
                 165                170                175
Arg Glu Asn Lys Asp Phe Ile Arg Pro Lys Leu Val Thr Ile Ile Arg 
             180                185                190
Ser Gly Val Lys Pro Arg Lys Ala Val Arg Ile Leu Leu Asn Lys Lys 
         195                200                205
Thr Ala His Ser Phe Glu Gln Val Leu Thr Asp Ile Thr Asp Ala Ile 
     210                215                220
Lys Leu Asp Ser Gly Val Val Lys Arg Leu Tyr Thr Leu Asp Gly Lys 
 225                230                235                240
Gln Val Met Cys Leu Gln Asp Phe Phe Gly Asp Asp Asp Ile Phe Ile 
                 245                250                255
Ala Cys Gly Pro Glu Lys Phe Arg Tyr Gln Asp Asp Phe Leu Leu Asp 
             260                265                270
Glu Ser Glu Cys Arg Val Val Lys Ser Thr Ser Tyr Thr Lys Ile Ala 
         275                280                285
Ser Ser Ser Arg Arg Ser Thr Thr Lys Ser Pro Gly Pro Ser Arg Arg 
     290                295                300
Ser Lys Ser Pro Ala Ser Thr Ser Ser Val Asn Gly Thr Pro Gly Ser 
 305                310                315                320
Gln Leu Ser Thr Pro Arg Ser Gly Lys Ser Pro Ser Pro Ser Pro Thr 
                 325                330                335
Ser Pro Gly Ser Leu Arg Lys Gln Arg Ser Ser Gln His Gly Gly Ser 
             340                345                350
Ser Thr Ser Leu Ala Ser Thr Lys Val Cys Ser Ser Met Asp Glu Asn 
         355                360                365
Asp Gly Pro Gly Glu Glu Val Ser Glu Glu Gly Phe Gln Ile Pro Ala 
     370                375                380
Thr Ile Thr Glu Arg Tyr Lys Val Gly Arg Thr Ile Gly Asp Gly Asn 
 385                390                395                400
Phe Ala Val Val Lys Glu Cys Val Glu Arg Ser Thr Ala Arg Glu Tyr 
                 405                410                415
Ala Leu Lys Ile Ile Lys Lys Ser Lys Cys Arg Gly Lys Glu His Met 
             420                425                430
Ile Gln Asn Glu Val Ser Ile Leu Arg Arg Val Lys His Pro Asn Ile 
         435                440                445
Val Leu Leu Ile Glu Glu Met Asp Val Pro Thr Glu Leu Tyr Leu Val 
     450                455                460
Met Glu Leu Val Lys Gly Gly Asp Leu Phe Asp Ala Ile Thr Ser Thr 
 465                470                475                480
Asn Lys Tyr Thr Glu Arg Asp Ala Ser Gly Met Leu Tyr Asn Leu Ala 
                 485                490                495
Ser Ala Ile Lys Tyr Leu His Ser Leu Asn Ile Val His Arg Asp Ile 
             500                505                510
Lys Pro Glu Asn Leu Leu Val Tyr Glu His Gln Asp Gly Ser Lys Ser 
         515                520                525
Leu Lys Leu Gly Asp Phe Gly Leu Ala Thr Ile Val Asp Gly Pro Leu 
     530                535                540
Tyr Thr Val Cys Gly Thr Pro Thr Tyr Val Ala Pro Glu Ile Ile Ala 
 545                550                555                560
Glu Thr Gly Tyr Gly Leu Lys Val Asp Ile Trp Ala Ala Gly Val Ile 
                 565                570                575
Thr Tyr Ile Leu Leu Cys Gly Phe Pro Pro Phe Arg Gly Ser Gly Asp 
             580                585                590
Asp Gln Glu Val Leu Phe Asp Gln Ile Leu Met Gly Gln Val Asp Phe 
         595                600                605
Pro Ser Pro Tyr Trp Asp Asn Val Ser Asp Ser Ala Lys Glu Leu Ile 
     610                615                620
Thr Met Met Leu Leu Val Asp Val Asp Gln Arg Phe Ser Ala Val Gln 
 625                630                635                640
Val Leu Glu His Pro Trp Val Asn Asp Asp Gly Leu Pro Glu Asn Glu 
                 645                650                655
His Gln Leu Ser Val Ala Gly Lys Ile Lys Lys His Phe Asn Thr Gly 
             660                665                670
Pro Lys Pro Asn Ser Thr Ala Ala Gly Val Ser Val Ile Ala Thr Thr 
         675                680                685
Ala Leu Asp Lys Glu Arg Gln Val Phe Arg Arg Arg Arg Asn Gln Asp 
     690                695                700
Val Arg Ser Arg Tyr Lys Ala Gln Pro Ala Pro Pro Glu Leu Asn Ser 
 705                710                715                720
Glu Ser Glu Asp Tyr Ser Pro Ser Ser Ser Glu Thr Val Arg Ser Pro 
                 725                730                735
Asn Ser Pro Phe 
             740



<210> 622
<211> 2128
<212> DNA
<213> Rattus norvegicus
<308> AF030091
<400> 622

gtcacggga  gatccgtcg  gccgaggac  ctggttagt  tcgctttgg  ttccggctg  60
gtcgggcgt  cgtgtagct  gctagaact  tggcgtccg  gcctcaccc  acatcgacc  120
ctgccgccg  ctctgcctc  tccgccgcc  cgagtgcgg  cggctccag  tccggcacg  180
cgaccacga  gacgacgac  accggaggg  tcctgattg  cgaccgcct  tactcggag  240
tgtcgctta  catcgacca  tcggtgatt  cggaggagc  gctctcgcc  accccgtcc  300
tgcaggacg  cctcgacct  cccagcgag  cggacctgc  catcttagg  tgcgagctc  360
tccaggccg  cggcattct  ctccggctg  cgcaggtgg  gatggctac  gggcaggtg  420
tgtttcatc  ttttttcta  tccaagtct  tcgtcaaac  cagtttcga  attgttgcc  480
tggcctgta  taatcttgc  tcaaaaatt  aagaagcac  aagaagaat  agagatgtg  540
ttaatgtat  ccaccacct  cgccagtta  gaggaaaaa  gactccaag  cccctgatc  600
ttgatcaga  ctacattaa  accaaaaat  aagttatca  ggcagagag  agggtgcta  660
aggagttgg  attttgtgt  catgtcaag  atccccata  gatcattgt  atgtattta  720
aagtcttag  atgtgaacg  aaccaaacc  tggttcaga  tgcctggaa  tatatgaat  780
acagtcttc  aaccaatgt  tttgttcgc  ttcaaccag  gactatagc  tgtgcttgt  840
tctaccttg  agctagagc  cttcaaatt  cattgccaa  tcggcccca  tggtttctt  900
tttttggta  cacagaaga  gagattcaa  aaatctgca  agagacact  agactttat  960
ccaggaaaa  gcctaacta  gaattgctg  aaaaggaag  agaaaaaag  aaagtagcc  1020
tacaggaag  caagttaaa  gcaaaggga  tgaatcttg  tggaactcc  gccctttcc  1080
ctttaggtg  tttttctcc  gcctccaaa  catcatcac  aagagaagt  aaagctgaa  1140
agaaatcac  agtttccat  aatgtgaag  cagtcaaaa  agaacctga  gatagacaa  1200
aagcttcca  aagccctta  aatggtgta  gaaaagaca  caagagaag  agaaacagc  1260
gaagtgcca  tagatcaag  tcaagaacc  ggtcacgct  tagatcaca  accccaaga  1320
gacattata  taataggcg  agtcgatct  gaacataca  ctcaagatc  agaagcagg  1380
ctcgcagtc  cagtgaaag  cctcgaaga  atcataatc  tggttctcc  caccttaag  1440
ccaaacata  cagagaaga  ttaaaaagc  caaatagac  tggtcataa  aggaaaaaa  1500
ctcggtctc  atctcagag  aagactcgg  atcactcag  tgttaccaa  aaacacagg  1560
atgaaaggg  gcatcacag  gacaggcgt  aaagatctc  ctcctttga  aggtcccat  1620
aaggcaagc  ccacggtgg  agtcgctca  gacatggca  gcataggcg  tgactttca  1680
cctctgaca  tgcatcggt  cctggtgtt  cccatatgc  gtgtgacga  gtatggact  1740
aatcaaaac  tgaaaagca  actgattag  gattgattt  ttaaaattg  ctaggtttc  1800
agaaacact  aggacattt  cttttgaaa  gaactatgt  aaggttttt  gcacattaa  1860
atgccctag  agtatctaa  tgaaaacca  ggtcaggtt  aattgtact  tattatagt  1920
gtgtattgt  tattgctat  agaactgga  cgtaaattc  gtaaaaatg  atcttattt  1980
tatacagat  aaacttgca  acactgttc  atttaagtg  ttatttgtt  aaatgatgg  2040
gaatacttt  ttaacactg  tttgtccgc  tgtgtaaag  tttttacaa  gaaataaaa  2100
acaaatctt  tttttctaa  aaaaaaaa  2128



<210> 623
<211> 527
<212> PRT
<213> Rattus norvegicus
<308> AAD45558
<400> 623

Met Ala Ser Gly Pro His Pro Thr Ser Thr Ala Ala Ala Ala Ser Ala 
  1               5                  10                  15
Ser Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr 
             20                  25                  30
Thr Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr 
         35                  40                  45
Ser Glu Val Ser Leu Thr Ile Asp His Ser Val Ile Pro Glu Glu Arg 
     50                  55                  60
Leu Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu 
 65                  70                  75                  80
Thr Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile 
                 85                  90                  95
Leu Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe 
             100                105                110
His Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile 
         115                120                125
Val Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro 
     130                135                140
Arg Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu 
 145                150                155                160
Arg Gly Lys Arg Thr Pro Ser Pro Leu Ile Leu Asp Gln Asn Tyr Ile 
                 165                170                175
Asn Thr Lys Asn Gln Val Ile Lys Ala Glu Arg Arg Val Leu Lys Glu 
             180                185                190
Leu Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met 
         195                200                205
Tyr Leu Gln Val Leu Glu Cys Glu Arg Asn Gln Thr Leu Val Gln Thr 
     210                215                220
Ala Trp Asn Tyr Met Asn Asp Ser Leu Arg Thr Asn Val Phe Val Arg 
 225                230                235                240
Phe Gln Pro Glu Thr Ile Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg 
                 245                250                255
Ala Leu Gln Ile Pro Leu Pro Thr Arg Pro His Trp Phe Leu Leu Phe 
             260                265                270
Gly Thr Thr Glu Glu Glu Ile Gln Glu Ile Cys Ile Glu Thr Leu Arg 
         275                280                285
Leu Tyr Thr Arg Lys Lys Pro Asn Tyr Glu Leu Leu Glu Lys Glu Val 
     290                295                300
Glu Lys Arg Lys Val Ala Leu Gln Glu Ala Lys Leu Lys Ala Lys Gly 
 305                310                315                320
Leu Asn Leu Asp Gly Thr Pro Ala Leu Ser Thr Leu Gly Gly Phe Ser 
                 325                330                335
Pro Ala Ser Lys Pro Ser Ser Pro Arg Glu Val Lys Ala Glu Glu Lys 
             340                345                350
Ser Pro Val Ser Ile Asn Val Lys Thr Val Lys Lys Glu Pro Glu Asp 
         355                360                365
Arg Gln Gln Ala Ser Lys Ser Pro Tyr Asn Gly Val Arg Lys Asp Ser 
     370                375                380
Lys Arg Ser Arg Asn Ser Arg Ser Ala Ser Arg Ser Arg Ser Arg Thr 
 385                390                395                400
Arg Ser Arg Ser Arg Ser His Thr Pro Arg Arg His Tyr Asn Asn Arg 
                 405                410                415
Arg Ser Arg Ser Gly Thr Tyr Ser Ser Arg Ser Arg Ser Arg Ser Arg 
             420                425                430
Ser His Ser Glu Ser Pro Arg Arg His His Asn His Gly Ser Pro His 
         435                440                445
Leu Lys Ala Lys His Thr Arg Glu Asp Leu Lys Ser Ser Asn Arg His 
     450                455                460
Gly His Lys Arg Lys Lys Ser Arg Ser Arg Ser Gln Ser Lys Thr Arg 
 465                470                475                480
Asp His Ser Asp Val Thr Lys Lys His Arg His Glu Arg Gly His His 
                 485                490                495
Arg Asp Arg Arg Glu Arg Ser Arg Ser Phe Glu Arg Ser His Lys Gly 
             500                505                510
Lys His His Gly Gly Ser Arg Ser Gly His Gly Arg His Arg Arg 
         515                520                525



<210> 624
<211> 1875
<212> DNA
<213> Homo sapiens
<308> AY034790
<400> 624

ttttttttt  ttaaagtta  agcaagttt  ttaagaaag  aaaggaata  agaatggct  60
ctccatagg  atagcagcc  cgagggctg  tggttgccc  ttttaacgg  tatttcttg  120
tgatatgct  aacaagggg  gtattattc  tgcctcccc  ttttagacc  tataggata  180
cttcctgat  ttgccatgg  atttgtaaa  tgtcatggc  ctggtggga  tgtagcagt  240
aggacgacc  gaggtcact  tcgttgcca  cttggtttt  gtgggtttt  gctggcttc  300
ttactgcaa  cattttatc  gcaagcggc  cgctaagac  atggcgtcc  ggcctcatt  360
gacagctac  gctgccgca  ccgcctcat  ggccgcccc  agcgcgggc  gctccagct  420
cgggacgac  accacgacg  cgaccacga  gggagggat  ctgatcggc  atcgcctgt  480
ctcggaagt  tcacttacc  tcgaccact  tctgattcc  gaggagagg  tctcgccca  540
cccatccat  caggatggg  tcgacctgc  cagtgagac  gacttacgc  tcctgggct  600
cgagctcat  caggctgcc  gcattctcc  ccggctgcc  caggtggcg  tggcaacgg  660
gcaggtgtt  tttcatcgt  ttttctact  caaatcttt  gtcaaacac  gtttcgaga  720
tgttgctat  gcttgtatt  atcttgcat  aaaaatcga  gaagcacct  gaagaataa  780
agatgtgat  aatgtattc  accacctcc  ccagttaag  ggaaaaagc  accagctac  840
tttaccaaa  cctgggtga  gtggagtgg  acatagaga  gaagctgtc  tcatggcaa  900
agactccaa  ccccctgat  cttgatcag  actacatta  caccaaaaa  caagttatc  960
aagcagaga  gagggtgct  aaggagttg  gattttgtg  tcatgtcaa  catcctcat  1020
agatcattg  tatgtattt  caagtctta  aatgtgaac  taatcaaac  ctggttcaa  1080
ctgcctgga  ttacatgaa  gacagtctt  gaaccaatg  gtttgttcg  tttcaacca  1140
agactatag  atgtgcttg  atctacctt  cagctagag  acttcagat  ccgttgcca  1200
ctcgtcccc  ttggtttct  ctttttggt  ctacagaag  ggaaatcca  gaaatctgc  1260
tagaaacac  taggcttta  accagaaaa  agccaaact  tgaattact  gaaaaagaa  1320
tagaaaaaa  aaaagtagc  ttacaagaa  ccaaattaa  agcaaaggg  ttgaatccg  1380
atggaactc  agccctttc  accctgggt  gattttctc  agcctccaa  ccatcatca  1440
caagagaag  aaaagctga  gagaaatca  caatctcca  taatgtgaa  acagtcaaa  1500
aagaacctg  ggatagaca  caggcttcc  aaagccctt  caatggtgt  agaaaagac  1560
gcaagagaa  tagaaatag  agaagtgca  gtcgatcga  gtcaagaac  cgatcacgt  1620
ctagatcac  tactccaag  agacagcaa  caaatgttt  cttagggaa  cagtcttat  1680
tggagtttt  aaaggttat  gctttttct  taaaaattg  acatagatt  ttttcaaag  1740
taggttaga  ttaggcttt  cagtatgag  caaattatg  gaaatgagt  tggagatgt  1800
ctggacata  agtatctta  tggcattct  ttatatttt  tcccatgtt  tttggagaa  1860
tgtaggagc  acccg  1875



<210> 625
<211> 526
<212> PRT
<213> Homo sapiens
<308> NP_064703
<400> 625

Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser 
  1               5                  10                  15
Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr 
             20                  25                  30
Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser 
         35                  40                  45
Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu 
     50                  55                  60
Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr 
 65                  70                  75                  80
Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu 
                 85                  90                  95
Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His 
             100                105                110
Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val 
         115                120                125
Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg 
     130                135                140
Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg 
 145                150                155                160
Gly Lys Arg Thr Pro Ser Pro Leu Ile Leu Asp Gln Asn Tyr Ile Asn 
                 165                170                175
Thr Lys Asn Gln Val Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu 
             180                185                190
Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met Tyr 
         195                200                205
Leu Gln Val Leu Glu Cys Glu Arg Asn Gln Thr Leu Val Gln Thr Ala 
     210                215                220
Trp Asn Tyr Met Asn Asp Ser Leu Arg Thr Asn Val Phe Val Arg Phe 
 225                230                235                240
Gln Pro Glu Thr Ile Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg Ala 
                 245                250                255
Leu Gln Ile Pro Leu Pro Thr Arg Pro His Trp Phe Leu Leu Phe Gly 
             260                265                270
Thr Thr Glu Glu Glu Ile Gln Glu Ile Cys Ile Glu Thr Leu Arg Leu 
         275                280                285
Tyr Thr Arg Lys Lys Pro Asn Tyr Glu Leu Leu Glu Lys Glu Val Glu 
     290                295                300
Lys Arg Lys Val Ala Leu Gln Glu Ala Lys Leu Lys Ala Lys Gly Leu 
 305                310                315                320
Asn Pro Asp Gly Thr Pro Ala Leu Ser Thr Leu Gly Gly Phe Ser Pro 
                 325                330                335
Ala Ser Lys Pro Ser Ser Pro Arg Glu Val Lys Ala Glu Glu Lys Ser 
             340                345                350
Pro Ile Ser Ile Asn Val Lys Thr Val Lys Lys Glu Pro Glu Asp Arg 
         355                360                365
Gln Gln Ala Ser Lys Ser Pro Tyr Asn Gly Val Arg Lys Asp Ser Lys 
     370                375                380
Arg Ser Arg Asn Ser Arg Ser Ala Ser Arg Ser Arg Ser Arg Thr Arg 
 385                390                395                400
Ser Arg Ser Arg Ser His Thr Pro Arg Arg His Tyr Asn Asn Arg Arg 
                 405                410                415
Ser Arg Ser Gly Thr Tyr Ser Ser Arg Ser Arg Ser Arg Ser Arg Ser 
             420                425                430
His Ser Glu Ser Pro Arg Arg His His Asn His Gly Ser Pro His Leu 
         435                440                445
Lys Ala Lys His Thr Arg Asp Asp Leu Lys Ser Ser Asn Arg His Gly 
     450                455                460
His Lys Arg Lys Lys Ser Arg Ser Arg Ser Gln Ser Lys Ser Arg Asp 
 465                470                475                480
His Ser Asp Ala Ala Lys Lys His Arg His Glu Arg Gly His His Arg 
                 485                490                495
Asp Arg Arg Glu Arg Ser Arg Ser Phe Glu Arg Ser His Lys Ser Lys 
             500                505                510
His His Gly Gly Ser Arg Ser Gly His Gly Arg His Arg Arg 
         515                520                525



<210> 626
<211> 2128
<212> DNA
<213> Rattus norvegicus
<308> AF030091
<400> 626

gtcacggga  gatccgtcg  gccgaggac  ctggttagt  tcgctttgg  ttccggctg  60
gtcgggcgt  cgtgtagct  gctagaact  tggcgtccg  gcctcaccc  acatcgacc  120
ctgccgccg  ctctgcctc  tccgccgcc  cgagtgcgg  cggctccag  tccggcacg  180
cgaccacga  gacgacgac  accggaggg  tcctgattg  cgaccgcct  tactcggag  240
tgtcgctta  catcgacca  tcggtgatt  cggaggagc  gctctcgcc  accccgtcc  300
tgcaggacg  cctcgacct  cccagcgag  cggacctgc  catcttagg  tgcgagctc  360
tccaggccg  cggcattct  ctccggctg  cgcaggtgg  gatggctac  gggcaggtg  420
tgtttcatc  ttttttcta  tccaagtct  tcgtcaaac  cagtttcga  attgttgcc  480
tggcctgta  taatcttgc  tcaaaaatt  aagaagcac  aagaagaat  agagatgtg  540
ttaatgtat  ccaccacct  cgccagtta  gaggaaaaa  gactccaag  cccctgatc  600
ttgatcaga  ctacattaa  accaaaaat  aagttatca  ggcagagag  agggtgcta  660
aggagttgg  attttgtgt  catgtcaag  atccccata  gatcattgt  atgtattta  720
aagtcttag  atgtgaacg  aaccaaacc  tggttcaga  tgcctggaa  tatatgaat  780
acagtcttc  aaccaatgt  tttgttcgc  ttcaaccag  gactatagc  tgtgcttgt  840
tctaccttg  agctagagc  cttcaaatt  cattgccaa  tcggcccca  tggtttctt  900
tttttggta  cacagaaga  gagattcaa  aaatctgca  agagacact  agactttat  960
ccaggaaaa  gcctaacta  gaattgctg  aaaaggaag  agaaaaaag  aaagtagcc  1020
tacaggaag  caagttaaa  gcaaaggga  tgaatcttg  tggaactcc  gccctttcc  1080
ctttaggtg  tttttctcc  gcctccaaa  catcatcac  aagagaagt  aaagctgaa  1140
agaaatcac  agtttccat  aatgtgaag  cagtcaaaa  agaacctga  gatagacaa  1200
aagcttcca  aagccctta  aatggtgta  gaaaagaca  caagagaag  agaaacagc  1260
gaagtgcca  tagatcaag  tcaagaacc  ggtcacgct  tagatcaca  accccaaga  1320
gacattata  taataggcg  agtcgatct  gaacataca  ctcaagatc  agaagcagg  1380
ctcgcagtc  cagtgaaag  cctcgaaga  atcataatc  tggttctcc  caccttaag  1440
ccaaacata  cagagaaga  ttaaaaagc  caaatagac  tggtcataa  aggaaaaaa  1500
ctcggtctc  atctcagag  aagactcgg  atcactcag  tgttaccaa  aaacacagg  1560
atgaaaggg  gcatcacag  gacaggcgt  aaagatctc  ctcctttga  aggtcccat  1620
aaggcaagc  ccacggtgg  agtcgctca  gacatggca  gcataggcg  tgactttca  1680
cctctgaca  tgcatcggt  cctggtgtt  cccatatgc  gtgtgacga  gtatggact  1740
aatcaaaac  tgaaaagca  actgattag  gattgattt  ttaaaattg  ctaggtttc  1800
agaaacact  aggacattt  cttttgaaa  gaactatgt  aaggttttt  gcacattaa  1860
atgccctag  agtatctaa  tgaaaacca  ggtcaggtt  aattgtact  tattatagt  1920
gtgtattgt  tattgctat  agaactgga  cgtaaattc  gtaaaaatg  atcttattt  1980
tatacagat  aaacttgca  acactgttc  atttaagtg  ttatttgtt  aaatgatgg  2040
gaatacttt  ttaacactg  tttgtccgc  tgtgtaaag  tttttacaa  gaaataaaa  2100
acaaatctt  tttttctaa  aaaaaaaa  2128



<210> 627
<211> 527
<212> PRT
<213> Rattus norvegicus
<308> AAD45558
<400> 627

Met Ala Ser Gly Pro His Pro Thr Ser Thr Ala Ala Ala Ala Ser Ala 
  1               5                  10                  15
Ser Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr 
             20                  25                  30
Thr Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr 
         35                  40                  45
Ser Glu Val Ser Leu Thr Ile Asp His Ser Val Ile Pro Glu Glu Arg 
     50                  55                  60
Leu Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu 
 65                  70                  75                  80
Thr Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile 
                 85                  90                  95
Leu Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe 
             100                105                110
His Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile 
         115                120                125
Val Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro 
     130                135                140
Arg Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu 
 145                150                155                160
Arg Gly Lys Arg Thr Pro Ser Pro Leu Ile Leu Asp Gln Asn Tyr Ile 
                 165                170                175
Asn Thr Lys Asn Gln Val Ile Lys Ala Glu Arg Arg Val Leu Lys Glu 
             180                185                190
Leu Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met 
         195                200                205
Tyr Leu Gln Val Leu Glu Cys Glu Arg Asn Gln Thr Leu Val Gln Thr 
     210                215                220
Ala Trp Asn Tyr Met Asn Asp Ser Leu Arg Thr Asn Val Phe Val Arg 
 225                230                235                240
Phe Gln Pro Glu Thr Ile Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg 
                 245                250                255
Ala Leu Gln Ile Pro Leu Pro Thr Arg Pro His Trp Phe Leu Leu Phe 
             260                265                270
Gly Thr Thr Glu Glu Glu Ile Gln Glu Ile Cys Ile Glu Thr Leu Arg 
         275                280                285
Leu Tyr Thr Arg Lys Lys Pro Asn Tyr Glu Leu Leu Glu Lys Glu Val 
     290                295                300
Glu Lys Arg Lys Val Ala Leu Gln Glu Ala Lys Leu Lys Ala Lys Gly 
 305                310                315                320
Leu Asn Leu Asp Gly Thr Pro Ala Leu Ser Thr Leu Gly Gly Phe Ser 
                 325                330                335
Pro Ala Ser Lys Pro Ser Ser Pro Arg Glu Val Lys Ala Glu Glu Lys 
             340                345                350
Ser Pro Val Ser Ile Asn Val Lys Thr Val Lys Lys Glu Pro Glu Asp 
         355                360                365
Arg Gln Gln Ala Ser Lys Ser Pro Tyr Asn Gly Val Arg Lys Asp Ser 
     370                375                380
Lys Arg Ser Arg Asn Ser Arg Ser Ala Ser Arg Ser Arg Ser Arg Thr 
 385                390                395                400
Arg Ser Arg Ser Arg Ser His Thr Pro Arg Arg His Tyr Asn Asn Arg 
                 405                410                415
Arg Ser Arg Ser Gly Thr Tyr Ser Ser Arg Ser Arg Ser Arg Ser Arg 
             420                425                430
Ser His Ser Glu Ser Pro Arg Arg His His Asn His Gly Ser Pro His 
         435                440                445
Leu Lys Ala Lys His Thr Arg Glu Asp Leu Lys Ser Ser Asn Arg His 
     450                455                460
Gly His Lys Arg Lys Lys Ser Arg Ser Arg Ser Gln Ser Lys Thr Arg 
 465                470                475                480
Asp His Ser Asp Val Thr Lys Lys His Arg His Glu Arg Gly His His 
                 485                490                495
Arg Asp Arg Arg Glu Arg Ser Arg Ser Phe Glu Arg Ser His Lys Gly 
             500                505                510
Lys His His Gly Gly Ser Arg Ser Gly His Gly Arg His Arg Arg 
         515                520                525



<210> 628
<211> 1875
<212> DNA
<213> Homo sapiens
<308> AY034790
<400> 628

ttttttttt  ttaaagtta  agcaagttt  ttaagaaag  aaaggaata  agaatggct  60
ctccatagg  atagcagcc  cgagggctg  tggttgccc  ttttaacgg  tatttcttg  120
tgatatgct  aacaagggg  gtattattc  tgcctcccc  ttttagacc  tataggata  180
cttcctgat  ttgccatgg  atttgtaaa  tgtcatggc  ctggtggga  tgtagcagt  240
aggacgacc  gaggtcact  tcgttgcca  cttggtttt  gtgggtttt  gctggcttc  300
ttactgcaa  cattttatc  gcaagcggc  cgctaagac  atggcgtcc  ggcctcatt  360
gacagctac  gctgccgca  ccgcctcat  ggccgcccc  agcgcgggc  gctccagct  420
cgggacgac  accacgacg  cgaccacga  gggagggat  ctgatcggc  atcgcctgt  480
ctcggaagt  tcacttacc  tcgaccact  tctgattcc  gaggagagg  tctcgccca  540
cccatccat  caggatggg  tcgacctgc  cagtgagac  gacttacgc  tcctgggct  600
cgagctcat  caggctgcc  gcattctcc  ccggctgcc  caggtggcg  tggcaacgg  660
gcaggtgtt  tttcatcgt  ttttctact  caaatcttt  gtcaaacac  gtttcgaga  720
tgttgctat  gcttgtatt  atcttgcat  aaaaatcga  gaagcacct  gaagaataa  780
agatgtgat  aatgtattc  accacctcc  ccagttaag  ggaaaaagc  accagctac  840
tttaccaaa  cctgggtga  gtggagtgg  acatagaga  gaagctgtc  tcatggcaa  900
agactccaa  ccccctgat  cttgatcag  actacatta  caccaaaaa  caagttatc  960
aagcagaga  gagggtgct  aaggagttg  gattttgtg  tcatgtcaa  catcctcat  1020
agatcattg  tatgtattt  caagtctta  aatgtgaac  taatcaaac  ctggttcaa  1080
ctgcctgga  ttacatgaa  gacagtctt  gaaccaatg  gtttgttcg  tttcaacca  1140
agactatag  atgtgcttg  atctacctt  cagctagag  acttcagat  ccgttgcca  1200
ctcgtcccc  ttggtttct  ctttttggt  ctacagaag  ggaaatcca  gaaatctgc  1260
tagaaacac  taggcttta  accagaaaa  agccaaact  tgaattact  gaaaaagaa  1320
tagaaaaaa  aaaagtagc  ttacaagaa  ccaaattaa  agcaaaggg  ttgaatccg  1380
atggaactc  agccctttc  accctgggt  gattttctc  agcctccaa  ccatcatca  1440
caagagaag  aaaagctga  gagaaatca  caatctcca  taatgtgaa  acagtcaaa  1500
aagaacctg  ggatagaca  caggcttcc  aaagccctt  caatggtgt  agaaaagac  1560
gcaagagaa  tagaaatag  agaagtgca  gtcgatcga  gtcaagaac  cgatcacgt  1620
ctagatcac  tactccaag  agacagcaa  caaatgttt  cttagggaa  cagtcttat  1680
tggagtttt  aaaggttat  gctttttct  taaaaattg  acatagatt  ttttcaaag  1740
taggttaga  ttaggcttt  cagtatgag  caaattatg  gaaatgagt  tggagatgt  1800
ctggacata  agtatctta  tggcattct  ttatatttt  tcccatgtt  tttggagaa  1860
tgtaggagc  acccg  1875



<210> 629
<211> 526
<212> PRT
<213> Homo sapiens
<308> NP_064703
<400> 629

Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser 
  1               5                  10                  15
Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr 
             20                  25                  30
Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser 
         35                  40                  45
Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu 
     50                  55                  60
Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr 
 65                  70                  75                  80
Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu 
                 85                  90                  95
Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His 
             100                105                110
Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val 
         115                120                125
Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg 
     130                135                140
Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg 
 145                150                155                160
Gly Lys Arg Thr Pro Ser Pro Leu Ile Leu Asp Gln Asn Tyr Ile Asn 
                 165                170                175
Thr Lys Asn Gln Val Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu 
             180                185                190
Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met Tyr 
         195                200                205
Leu Gln Val Leu Glu Cys Glu Arg Asn Gln Thr Leu Val Gln Thr Ala 
     210                215                220
Trp Asn Tyr Met Asn Asp Ser Leu Arg Thr Asn Val Phe Val Arg Phe 
 225                230                235                240
Gln Pro Glu Thr Ile Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg Ala 
                 245                250                255
Leu Gln Ile Pro Leu Pro Thr Arg Pro His Trp Phe Leu Leu Phe Gly 
             260                265                270
Thr Thr Glu Glu Glu Ile Gln Glu Ile Cys Ile Glu Thr Leu Arg Leu 
         275                280                285
Tyr Thr Arg Lys Lys Pro Asn Tyr Glu Leu Leu Glu Lys Glu Val Glu 
     290                295                300
Lys Arg Lys Val Ala Leu Gln Glu Ala Lys Leu Lys Ala Lys Gly Leu 
 305                310                315                320
Asn Pro Asp Gly Thr Pro Ala Leu Ser Thr Leu Gly Gly Phe Ser Pro 
                 325                330                335
Ala Ser Lys Pro Ser Ser Pro Arg Glu Val Lys Ala Glu Glu Lys Ser 
             340                345                350
Pro Ile Ser Ile Asn Val Lys Thr Val Lys Lys Glu Pro Glu Asp Arg 
         355                360                365
Gln Gln Ala Ser Lys Ser Pro Tyr Asn Gly Val Arg Lys Asp Ser Lys 
     370                375                380
Arg Ser Arg Asn Ser Arg Ser Ala Ser Arg Ser Arg Ser Arg Thr Arg 
 385                390                395                400
Ser Arg Ser Arg Ser His Thr Pro Arg Arg His Tyr Asn Asn Arg Arg 
                 405                410                415
Ser Arg Ser Gly Thr Tyr Ser Ser Arg Ser Arg Ser Arg Ser Arg Ser 
             420                425                430
His Ser Glu Ser Pro Arg Arg His His Asn His Gly Ser Pro His Leu 
         435                440                445
Lys Ala Lys His Thr Arg Asp Asp Leu Lys Ser Ser Asn Arg His Gly 
     450                455                460
His Lys Arg Lys Lys Ser Arg Ser Arg Ser Gln Ser Lys Ser Arg Asp 
 465                470                475                480
His Ser Asp Ala Ala Lys Lys His Arg His Glu Arg Gly His His Arg 
                 485                490                495
Asp Arg Arg Glu Arg Ser Arg Ser Phe Glu Arg Ser His Lys Ser Lys 
             500                505                510
His His Gly Gly Ser Arg Ser Gly His Gly Arg His Arg Arg 
         515                520                525



<210> 630
<211> 2128
<212> DNA
<213> Rattus norvegicus
<308> AF030091
<400> 630

gtcacggga  gatccgtcg  gccgaggac  ctggttagt  tcgctttgg  ttccggctg  60
gtcgggcgt  cgtgtagct  gctagaact  tggcgtccg  gcctcaccc  acatcgacc  120
ctgccgccg  ctctgcctc  tccgccgcc  cgagtgcgg  cggctccag  tccggcacg  180
cgaccacga  gacgacgac  accggaggg  tcctgattg  cgaccgcct  tactcggag  240
tgtcgctta  catcgacca  tcggtgatt  cggaggagc  gctctcgcc  accccgtcc  300
tgcaggacg  cctcgacct  cccagcgag  cggacctgc  catcttagg  tgcgagctc  360
tccaggccg  cggcattct  ctccggctg  cgcaggtgg  gatggctac  gggcaggtg  420
tgtttcatc  ttttttcta  tccaagtct  tcgtcaaac  cagtttcga  attgttgcc  480
tggcctgta  taatcttgc  tcaaaaatt  aagaagcac  aagaagaat  agagatgtg  540
ttaatgtat  ccaccacct  cgccagtta  gaggaaaaa  gactccaag  cccctgatc  600
ttgatcaga  ctacattaa  accaaaaat  aagttatca  ggcagagag  agggtgcta  660
aggagttgg  attttgtgt  catgtcaag  atccccata  gatcattgt  atgtattta  720
aagtcttag  atgtgaacg  aaccaaacc  tggttcaga  tgcctggaa  tatatgaat  780
acagtcttc  aaccaatgt  tttgttcgc  ttcaaccag  gactatagc  tgtgcttgt  840
tctaccttg  agctagagc  cttcaaatt  cattgccaa  tcggcccca  tggtttctt  900
tttttggta  cacagaaga  gagattcaa  aaatctgca  agagacact  agactttat  960
ccaggaaaa  gcctaacta  gaattgctg  aaaaggaag  agaaaaaag  aaagtagcc  1020
tacaggaag  caagttaaa  gcaaaggga  tgaatcttg  tggaactcc  gccctttcc  1080
ctttaggtg  tttttctcc  gcctccaaa  catcatcac  aagagaagt  aaagctgaa  1140
agaaatcac  agtttccat  aatgtgaag  cagtcaaaa  agaacctga  gatagacaa  1200
aagcttcca  aagccctta  aatggtgta  gaaaagaca  caagagaag  agaaacagc  1260
gaagtgcca  tagatcaag  tcaagaacc  ggtcacgct  tagatcaca  accccaaga  1320
gacattata  taataggcg  agtcgatct  gaacataca  ctcaagatc  agaagcagg  1380
ctcgcagtc  cagtgaaag  cctcgaaga  atcataatc  tggttctcc  caccttaag  1440
ccaaacata  cagagaaga  ttaaaaagc  caaatagac  tggtcataa  aggaaaaaa  1500
ctcggtctc  atctcagag  aagactcgg  atcactcag  tgttaccaa  aaacacagg  1560
atgaaaggg  gcatcacag  gacaggcgt  aaagatctc  ctcctttga  aggtcccat  1620
aaggcaagc  ccacggtgg  agtcgctca  gacatggca  gcataggcg  tgactttca  1680
cctctgaca  tgcatcggt  cctggtgtt  cccatatgc  gtgtgacga  gtatggact  1740
aatcaaaac  tgaaaagca  actgattag  gattgattt  ttaaaattg  ctaggtttc  1800
agaaacact  aggacattt  cttttgaaa  gaactatgt  aaggttttt  gcacattaa  1860
atgccctag  agtatctaa  tgaaaacca  ggtcaggtt  aattgtact  tattatagt  1920
gtgtattgt  tattgctat  agaactgga  cgtaaattc  gtaaaaatg  atcttattt  1980
tatacagat  aaacttgca  acactgttc  atttaagtg  ttatttgtt  aaatgatgg  2040
gaatacttt  ttaacactg  tttgtccgc  tgtgtaaag  tttttacaa  gaaataaaa  2100
acaaatctt  tttttctaa  aaaaaaaa  2128



<210> 631
<211> 527
<212> PRT
<213> Rattus norvegicus
<308> AAD45558
<400> 631

Met Ala Ser Gly Pro His Pro Thr Ser Thr Ala Ala Ala Ala Ser Ala 
  1               5                  10                  15
Ser Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr 
             20                  25                  30
Thr Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr 
         35                  40                  45
Ser Glu Val Ser Leu Thr Ile Asp His Ser Val Ile Pro Glu Glu Arg 
     50                  55                  60
Leu Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu 
 65                  70                  75                  80
Thr Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile 
                 85                  90                  95
Leu Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe 
             100                105                110
His Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile 
         115                120                125
Val Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro 
     130                135                140
Arg Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu 
 145                150                155                160
Arg Gly Lys Arg Thr Pro Ser Pro Leu Ile Leu Asp Gln Asn Tyr Ile 
                 165                170                175
Asn Thr Lys Asn Gln Val Ile Lys Ala Glu Arg Arg Val Leu Lys Glu 
             180                185                190
Leu Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met 
         195                200                205
Tyr Leu Gln Val Leu Glu Cys Glu Arg Asn Gln Thr Leu Val Gln Thr 
     210                215                220
Ala Trp Asn Tyr Met Asn Asp Ser Leu Arg Thr Asn Val Phe Val Arg 
 225                230                235                240
Phe Gln Pro Glu Thr Ile Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg 
                 245                250                255
Ala Leu Gln Ile Pro Leu Pro Thr Arg Pro His Trp Phe Leu Leu Phe 
             260                265                270
Gly Thr Thr Glu Glu Glu Ile Gln Glu Ile Cys Ile Glu Thr Leu Arg 
         275                280                285
Leu Tyr Thr Arg Lys Lys Pro Asn Tyr Glu Leu Leu Glu Lys Glu Val 
     290                295                300
Glu Lys Arg Lys Val Ala Leu Gln Glu Ala Lys Leu Lys Ala Lys Gly 
 305                310                315                320
Leu Asn Leu Asp Gly Thr Pro Ala Leu Ser Thr Leu Gly Gly Phe Ser 
                 325                330                335
Pro Ala Ser Lys Pro Ser Ser Pro Arg Glu Val Lys Ala Glu Glu Lys 
             340                345                350
Ser Pro Val Ser Ile Asn Val Lys Thr Val Lys Lys Glu Pro Glu Asp 
         355                360                365
Arg Gln Gln Ala Ser Lys Ser Pro Tyr Asn Gly Val Arg Lys Asp Ser 
     370                375                380
Lys Arg Ser Arg Asn Ser Arg Ser Ala Ser Arg Ser Arg Ser Arg Thr 
 385                390                395                400
Arg Ser Arg Ser Arg Ser His Thr Pro Arg Arg His Tyr Asn Asn Arg 
                 405                410                415
Arg Ser Arg Ser Gly Thr Tyr Ser Ser Arg Ser Arg Ser Arg Ser Arg 
             420                425                430
Ser His Ser Glu Ser Pro Arg Arg His His Asn His Gly Ser Pro His 
         435                440                445
Leu Lys Ala Lys His Thr Arg Glu Asp Leu Lys Ser Ser Asn Arg His 
     450                455                460
Gly His Lys Arg Lys Lys Ser Arg Ser Arg Ser Gln Ser Lys Thr Arg 
 465                470                475                480
Asp His Ser Asp Val Thr Lys Lys His Arg His Glu Arg Gly His His 
                 485                490                495
Arg Asp Arg Arg Glu Arg Ser Arg Ser Phe Glu Arg Ser His Lys Gly 
             500                505                510
Lys His His Gly Gly Ser Arg Ser Gly His Gly Arg His Arg Arg 
         515                520                525



<210> 632
<211> 1875
<212> DNA
<213> Homo sapiens
<308> AY034790
<400> 632

ttttttttt  ttaaagtta  agcaagttt  ttaagaaag  aaaggaata  agaatggct  60
ctccatagg  atagcagcc  cgagggctg  tggttgccc  ttttaacgg  tatttcttg  120
tgatatgct  aacaagggg  gtattattc  tgcctcccc  ttttagacc  tataggata  180
cttcctgat  ttgccatgg  atttgtaaa  tgtcatggc  ctggtggga  tgtagcagt  240
aggacgacc  gaggtcact  tcgttgcca  cttggtttt  gtgggtttt  gctggcttc  300
ttactgcaa  cattttatc  gcaagcggc  cgctaagac  atggcgtcc  ggcctcatt  360
gacagctac  gctgccgca  ccgcctcat  ggccgcccc  agcgcgggc  gctccagct  420
cgggacgac  accacgacg  cgaccacga  gggagggat  ctgatcggc  atcgcctgt  480
ctcggaagt  tcacttacc  tcgaccact  tctgattcc  gaggagagg  tctcgccca  540
cccatccat  caggatggg  tcgacctgc  cagtgagac  gacttacgc  tcctgggct  600
cgagctcat  caggctgcc  gcattctcc  ccggctgcc  caggtggcg  tggcaacgg  660
gcaggtgtt  tttcatcgt  ttttctact  caaatcttt  gtcaaacac  gtttcgaga  720
tgttgctat  gcttgtatt  atcttgcat  aaaaatcga  gaagcacct  gaagaataa  780
agatgtgat  aatgtattc  accacctcc  ccagttaag  ggaaaaagc  accagctac  840
tttaccaaa  cctgggtga  gtggagtgg  acatagaga  gaagctgtc  tcatggcaa  900
agactccaa  ccccctgat  cttgatcag  actacatta  caccaaaaa  caagttatc  960
aagcagaga  gagggtgct  aaggagttg  gattttgtg  tcatgtcaa  catcctcat  1020
agatcattg  tatgtattt  caagtctta  aatgtgaac  taatcaaac  ctggttcaa  1080
ctgcctgga  ttacatgaa  gacagtctt  gaaccaatg  gtttgttcg  tttcaacca  1140
agactatag  atgtgcttg  atctacctt  cagctagag  acttcagat  ccgttgcca  1200
ctcgtcccc  ttggtttct  ctttttggt  ctacagaag  ggaaatcca  gaaatctgc  1260
tagaaacac  taggcttta  accagaaaa  agccaaact  tgaattact  gaaaaagaa  1320
tagaaaaaa  aaaagtagc  ttacaagaa  ccaaattaa  agcaaaggg  ttgaatccg  1380
atggaactc  agccctttc  accctgggt  gattttctc  agcctccaa  ccatcatca  1440
caagagaag  aaaagctga  gagaaatca  caatctcca  taatgtgaa  acagtcaaa  1500
aagaacctg  ggatagaca  caggcttcc  aaagccctt  caatggtgt  agaaaagac  1560
gcaagagaa  tagaaatag  agaagtgca  gtcgatcga  gtcaagaac  cgatcacgt  1620
ctagatcac  tactccaag  agacagcaa  caaatgttt  cttagggaa  cagtcttat  1680
tggagtttt  aaaggttat  gctttttct  taaaaattg  acatagatt  ttttcaaag  1740
taggttaga  ttaggcttt  cagtatgag  caaattatg  gaaatgagt  tggagatgt  1800
ctggacata  agtatctta  tggcattct  ttatatttt  tcccatgtt  tttggagaa  1860
tgtaggagc  acccg  1875



<210> 633
<211> 526
<212> PRT
<213> Homo sapiens
<308> NP_064703
<400> 633

Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser 
  1               5                  10                  15
Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr 
             20                  25                  30
Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser 
         35                  40                  45
Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu 
     50                  55                  60
Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr 
 65                  70                  75                  80
Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu 
                 85                  90                  95
Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His 
             100                105                110
Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val 
         115                120                125
Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg 
     130                135                140
Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg 
 145                150                155                160
Gly Lys Arg Thr Pro Ser Pro Leu Ile Leu Asp Gln Asn Tyr Ile Asn 
                 165                170                175
Thr Lys Asn Gln Val Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu 
             180                185                190
Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met Tyr 
         195                200                205
Leu Gln Val Leu Glu Cys Glu Arg Asn Gln Thr Leu Val Gln Thr Ala 
     210                215                220
Trp Asn Tyr Met Asn Asp Ser Leu Arg Thr Asn Val Phe Val Arg Phe 
 225                230                235                240
Gln Pro Glu Thr Ile Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg Ala 
                 245                250                255
Leu Gln Ile Pro Leu Pro Thr Arg Pro His Trp Phe Leu Leu Phe Gly 
             260                265                270
Thr Thr Glu Glu Glu Ile Gln Glu Ile Cys Ile Glu Thr Leu Arg Leu 
         275                280                285
Tyr Thr Arg Lys Lys Pro Asn Tyr Glu Leu Leu Glu Lys Glu Val Glu 
     290                295                300
Lys Arg Lys Val Ala Leu Gln Glu Ala Lys Leu Lys Ala Lys Gly Leu 
 305                310                315                320
Asn Pro Asp Gly Thr Pro Ala Leu Ser Thr Leu Gly Gly Phe Ser Pro 
                 325                330                335
Ala Ser Lys Pro Ser Ser Pro Arg Glu Val Lys Ala Glu Glu Lys Ser 
             340                345                350
Pro Ile Ser Ile Asn Val Lys Thr Val Lys Lys Glu Pro Glu Asp Arg 
         355                360                365
Gln Gln Ala Ser Lys Ser Pro Tyr Asn Gly Val Arg Lys Asp Ser Lys 
     370                375                380
Arg Ser Arg Asn Ser Arg Ser Ala Ser Arg Ser Arg Ser Arg Thr Arg 
 385                390                395                400
Ser Arg Ser Arg Ser His Thr Pro Arg Arg His Tyr Asn Asn Arg Arg 
                 405                410                415
Ser Arg Ser Gly Thr Tyr Ser Ser Arg Ser Arg Ser Arg Ser Arg Ser 
             420                425                430
His Ser Glu Ser Pro Arg Arg His His Asn His Gly Ser Pro His Leu 
         435                440                445
Lys Ala Lys His Thr Arg Asp Asp Leu Lys Ser Ser Asn Arg His Gly 
     450                455                460
His Lys Arg Lys Lys Ser Arg Ser Arg Ser Gln Ser Lys Ser Arg Asp 
 465                470                475                480
His Ser Asp Ala Ala Lys Lys His Arg His Glu Arg Gly His His Arg 
                 485                490                495
Asp Arg Arg Glu Arg Ser Arg Ser Phe Glu Arg Ser His Lys Ser Lys 
             500                505                510
His His Gly Gly Ser Arg Ser Gly His Gly Arg His Arg Arg 
         515                520                525



<210> 634
<211> 2128
<212> DNA
<213> Rattus norvegicus
<308> AF030091
<400> 634

gtcacggga  gatccgtcg  gccgaggac  ctggttagt  tcgctttgg  ttccggctg  60
gtcgggcgt  cgtgtagct  gctagaact  tggcgtccg  gcctcaccc  acatcgacc  120
ctgccgccg  ctctgcctc  tccgccgcc  cgagtgcgg  cggctccag  tccggcacg  180
cgaccacga  gacgacgac  accggaggg  tcctgattg  cgaccgcct  tactcggag  240
tgtcgctta  catcgacca  tcggtgatt  cggaggagc  gctctcgcc  accccgtcc  300
tgcaggacg  cctcgacct  cccagcgag  cggacctgc  catcttagg  tgcgagctc  360
tccaggccg  cggcattct  ctccggctg  cgcaggtgg  gatggctac  gggcaggtg  420
tgtttcatc  ttttttcta  tccaagtct  tcgtcaaac  cagtttcga  attgttgcc  480
tggcctgta  taatcttgc  tcaaaaatt  aagaagcac  aagaagaat  agagatgtg  540
ttaatgtat  ccaccacct  cgccagtta  gaggaaaaa  gactccaag  cccctgatc  600
ttgatcaga  ctacattaa  accaaaaat  aagttatca  ggcagagag  agggtgcta  660
aggagttgg  attttgtgt  catgtcaag  atccccata  gatcattgt  atgtattta  720
aagtcttag  atgtgaacg  aaccaaacc  tggttcaga  tgcctggaa  tatatgaat  780
acagtcttc  aaccaatgt  tttgttcgc  ttcaaccag  gactatagc  tgtgcttgt  840
tctaccttg  agctagagc  cttcaaatt  cattgccaa  tcggcccca  tggtttctt  900
tttttggta  cacagaaga  gagattcaa  aaatctgca  agagacact  agactttat  960
ccaggaaaa  gcctaacta  gaattgctg  aaaaggaag  agaaaaaag  aaagtagcc  1020
tacaggaag  caagttaaa  gcaaaggga  tgaatcttg  tggaactcc  gccctttcc  1080
ctttaggtg  tttttctcc  gcctccaaa  catcatcac  aagagaagt  aaagctgaa  1140
agaaatcac  agtttccat  aatgtgaag  cagtcaaaa  agaacctga  gatagacaa  1200
aagcttcca  aagccctta  aatggtgta  gaaaagaca  caagagaag  agaaacagc  1260
gaagtgcca  tagatcaag  tcaagaacc  ggtcacgct  tagatcaca  accccaaga  1320
gacattata  taataggcg  agtcgatct  gaacataca  ctcaagatc  agaagcagg  1380
ctcgcagtc  cagtgaaag  cctcgaaga  atcataatc  tggttctcc  caccttaag  1440
ccaaacata  cagagaaga  ttaaaaagc  caaatagac  tggtcataa  aggaaaaaa  1500
ctcggtctc  atctcagag  aagactcgg  atcactcag  tgttaccaa  aaacacagg  1560
atgaaaggg  gcatcacag  gacaggcgt  aaagatctc  ctcctttga  aggtcccat  1620
aaggcaagc  ccacggtgg  agtcgctca  gacatggca  gcataggcg  tgactttca  1680
cctctgaca  tgcatcggt  cctggtgtt  cccatatgc  gtgtgacga  gtatggact  1740
aatcaaaac  tgaaaagca  actgattag  gattgattt  ttaaaattg  ctaggtttc  1800
agaaacact  aggacattt  cttttgaaa  gaactatgt  aaggttttt  gcacattaa  1860
atgccctag  agtatctaa  tgaaaacca  ggtcaggtt  aattgtact  tattatagt  1920
gtgtattgt  tattgctat  agaactgga  cgtaaattc  gtaaaaatg  atcttattt  1980
tatacagat  aaacttgca  acactgttc  atttaagtg  ttatttgtt  aaatgatgg  2040
gaatacttt  ttaacactg  tttgtccgc  tgtgtaaag  tttttacaa  gaaataaaa  2100
acaaatctt  tttttctaa  aaaaaaaa  2128



<210> 635
<211> 527
<212> PRT
<213> Rattus norvegicus
<308> AAD45558
<400> 635

Met Ala Ser Gly Pro His Pro Thr Ser Thr Ala Ala Ala Ala Ser Ala 
  1               5                  10                  15
Ser Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr 
             20                  25                  30
Thr Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr 
         35                  40                  45
Ser Glu Val Ser Leu Thr Ile Asp His Ser Val Ile Pro Glu Glu Arg 
     50                  55                  60
Leu Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu 
 65                  70                  75                  80
Thr Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile 
                 85                  90                  95
Leu Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe 
             100                105                110
His Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile 
         115                120                125
Val Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro 
     130                135                140
Arg Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu 
 145                150                155                160
Arg Gly Lys Arg Thr Pro Ser Pro Leu Ile Leu Asp Gln Asn Tyr Ile 
                 165                170                175
Asn Thr Lys Asn Gln Val Ile Lys Ala Glu Arg Arg Val Leu Lys Glu 
             180                185                190
Leu Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met 
         195                200                205
Tyr Leu Gln Val Leu Glu Cys Glu Arg Asn Gln Thr Leu Val Gln Thr 
     210                215                220
Ala Trp Asn Tyr Met Asn Asp Ser Leu Arg Thr Asn Val Phe Val Arg 
 225                230                235                240
Phe Gln Pro Glu Thr Ile Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg 
                 245                250                255
Ala Leu Gln Ile Pro Leu Pro Thr Arg Pro His Trp Phe Leu Leu Phe 
             260                265                270
Gly Thr Thr Glu Glu Glu Ile Gln Glu Ile Cys Ile Glu Thr Leu Arg 
         275                280                285
Leu Tyr Thr Arg Lys Lys Pro Asn Tyr Glu Leu Leu Glu Lys Glu Val 
     290                295                300
Glu Lys Arg Lys Val Ala Leu Gln Glu Ala Lys Leu Lys Ala Lys Gly 
 305                310                315                320
Leu Asn Leu Asp Gly Thr Pro Ala Leu Ser Thr Leu Gly Gly Phe Ser 
                 325                330                335
Pro Ala Ser Lys Pro Ser Ser Pro Arg Glu Val Lys Ala Glu Glu Lys 
             340                345                350
Ser Pro Val Ser Ile Asn Val Lys Thr Val Lys Lys Glu Pro Glu Asp 
         355                360                365
Arg Gln Gln Ala Ser Lys Ser Pro Tyr Asn Gly Val Arg Lys Asp Ser 
     370                375                380
Lys Arg Ser Arg Asn Ser Arg Ser Ala Ser Arg Ser Arg Ser Arg Thr 
 385                390                395                400
Arg Ser Arg Ser Arg Ser His Thr Pro Arg Arg His Tyr Asn Asn Arg 
                 405                410                415
Arg Ser Arg Ser Gly Thr Tyr Ser Ser Arg Ser Arg Ser Arg Ser Arg 
             420                425                430
Ser His Ser Glu Ser Pro Arg Arg His His Asn His Gly Ser Pro His 
         435                440                445
Leu Lys Ala Lys His Thr Arg Glu Asp Leu Lys Ser Ser Asn Arg His 
     450                455                460
Gly His Lys Arg Lys Lys Ser Arg Ser Arg Ser Gln Ser Lys Thr Arg 
 465                470                475                480
Asp His Ser Asp Val Thr Lys Lys His Arg His Glu Arg Gly His His 
                 485                490                495
Arg Asp Arg Arg Glu Arg Ser Arg Ser Phe Glu Arg Ser His Lys Gly 
             500                505                510
Lys His His Gly Gly Ser Arg Ser Gly His Gly Arg His Arg Arg 
         515                520                525



<210> 636
<211> 1875
<212> DNA
<213> Homo sapiens
<308> AY034790
<400> 636

ttttttttt  ttaaagtta  agcaagttt  ttaagaaag  aaaggaata  agaatggct  60
ctccatagg  atagcagcc  cgagggctg  tggttgccc  ttttaacgg  tatttcttg  120
tgatatgct  aacaagggg  gtattattc  tgcctcccc  ttttagacc  tataggata  180
cttcctgat  ttgccatgg  atttgtaaa  tgtcatggc  ctggtggga  tgtagcagt  240
aggacgacc  gaggtcact  tcgttgcca  cttggtttt  gtgggtttt  gctggcttc  300
ttactgcaa  cattttatc  gcaagcggc  cgctaagac  atggcgtcc  ggcctcatt  360
gacagctac  gctgccgca  ccgcctcat  ggccgcccc  agcgcgggc  gctccagct  420
cgggacgac  accacgacg  cgaccacga  gggagggat  ctgatcggc  atcgcctgt  480
ctcggaagt  tcacttacc  tcgaccact  tctgattcc  gaggagagg  tctcgccca  540
cccatccat  caggatggg  tcgacctgc  cagtgagac  gacttacgc  tcctgggct  600
cgagctcat  caggctgcc  gcattctcc  ccggctgcc  caggtggcg  tggcaacgg  660
gcaggtgtt  tttcatcgt  ttttctact  caaatcttt  gtcaaacac  gtttcgaga  720
tgttgctat  gcttgtatt  atcttgcat  aaaaatcga  gaagcacct  gaagaataa  780
agatgtgat  aatgtattc  accacctcc  ccagttaag  ggaaaaagc  accagctac  840
tttaccaaa  cctgggtga  gtggagtgg  acatagaga  gaagctgtc  tcatggcaa  900
agactccaa  ccccctgat  cttgatcag  actacatta  caccaaaaa  caagttatc  960
aagcagaga  gagggtgct  aaggagttg  gattttgtg  tcatgtcaa  catcctcat  1020
agatcattg  tatgtattt  caagtctta  aatgtgaac  taatcaaac  ctggttcaa  1080
ctgcctgga  ttacatgaa  gacagtctt  gaaccaatg  gtttgttcg  tttcaacca  1140
agactatag  atgtgcttg  atctacctt  cagctagag  acttcagat  ccgttgcca  1200
ctcgtcccc  ttggtttct  ctttttggt  ctacagaag  ggaaatcca  gaaatctgc  1260
tagaaacac  taggcttta  accagaaaa  agccaaact  tgaattact  gaaaaagaa  1320
tagaaaaaa  aaaagtagc  ttacaagaa  ccaaattaa  agcaaaggg  ttgaatccg  1380
atggaactc  agccctttc  accctgggt  gattttctc  agcctccaa  ccatcatca  1440
caagagaag  aaaagctga  gagaaatca  caatctcca  taatgtgaa  acagtcaaa  1500
aagaacctg  ggatagaca  caggcttcc  aaagccctt  caatggtgt  agaaaagac  1560
gcaagagaa  tagaaatag  agaagtgca  gtcgatcga  gtcaagaac  cgatcacgt  1620
ctagatcac  tactccaag  agacagcaa  caaatgttt  cttagggaa  cagtcttat  1680
tggagtttt  aaaggttat  gctttttct  taaaaattg  acatagatt  ttttcaaag  1740
taggttaga  ttaggcttt  cagtatgag  caaattatg  gaaatgagt  tggagatgt  1800
ctggacata  agtatctta  tggcattct  ttatatttt  tcccatgtt  tttggagaa  1860
tgtaggagc  acccg  1875



<210> 637
<211> 526
<212> PRT
<213> Homo sapiens
<308> NP_064703
<400> 637

Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser 
  1               5                  10                  15
Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr 
             20                  25                  30
Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser 
         35                  40                  45
Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu 
     50                  55                  60
Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr 
 65                  70                  75                  80
Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu 
                 85                  90                  95
Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His 
             100                105                110
Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val 
         115                120                125
Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg 
     130                135                140
Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg 
 145                150                155                160
Gly Lys Arg Thr Pro Ser Pro Leu Ile Leu Asp Gln Asn Tyr Ile Asn 
                 165                170                175
Thr Lys Asn Gln Val Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu 
             180                185                190
Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met Tyr 
         195                200                205
Leu Gln Val Leu Glu Cys Glu Arg Asn Gln Thr Leu Val Gln Thr Ala 
     210                215                220
Trp Asn Tyr Met Asn Asp Ser Leu Arg Thr Asn Val Phe Val Arg Phe 
 225                230                235                240
Gln Pro Glu Thr Ile Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg Ala 
                 245                250                255
Leu Gln Ile Pro Leu Pro Thr Arg Pro His Trp Phe Leu Leu Phe Gly 
             260                265                270
Thr Thr Glu Glu Glu Ile Gln Glu Ile Cys Ile Glu Thr Leu Arg Leu 
         275                280                285
Tyr Thr Arg Lys Lys Pro Asn Tyr Glu Leu Leu Glu Lys Glu Val Glu 
     290                295                300
Lys Arg Lys Val Ala Leu Gln Glu Ala Lys Leu Lys Ala Lys Gly Leu 
 305                310                315                320
Asn Pro Asp Gly Thr Pro Ala Leu Ser Thr Leu Gly Gly Phe Ser Pro 
                 325                330                335
Ala Ser Lys Pro Ser Ser Pro Arg Glu Val Lys Ala Glu Glu Lys Ser 
             340                345                350
Pro Ile Ser Ile Asn Val Lys Thr Val Lys Lys Glu Pro Glu Asp Arg 
         355                360                365
Gln Gln Ala Ser Lys Ser Pro Tyr Asn Gly Val Arg Lys Asp Ser Lys 
     370                375                380
Arg Ser Arg Asn Ser Arg Ser Ala Ser Arg Ser Arg Ser Arg Thr Arg 
 385                390                395                400
Ser Arg Ser Arg Ser His Thr Pro Arg Arg His Tyr Asn Asn Arg Arg 
                 405                410                415
Ser Arg Ser Gly Thr Tyr Ser Ser Arg Ser Arg Ser Arg Ser Arg Ser 
             420                425                430
His Ser Glu Ser Pro Arg Arg His His Asn His Gly Ser Pro His Leu 
         435                440                445
Lys Ala Lys His Thr Arg Asp Asp Leu Lys Ser Ser Asn Arg His Gly 
     450                455                460
His Lys Arg Lys Lys Ser Arg Ser Arg Ser Gln Ser Lys Ser Arg Asp 
 465                470                475                480
His Ser Asp Ala Ala Lys Lys His Arg His Glu Arg Gly His His Arg 
                 485                490                495
Asp Arg Arg Glu Arg Ser Arg Ser Phe Glu Arg Ser His Lys Ser Lys 
             500                505                510
His His Gly Gly Ser Arg Ser Gly His Gly Arg His Arg Arg 
         515                520                525



<210> 638
<211> 3044
<212> DNA
<213> Rattus norvegicus
<308> AF030358
<400> 638

tgcactcca  ccatccagc  atggctccc  cacagctcg  gtggctgct  cgcctggcc  60
cgttctttc  tctgtgtac  ctgctggcg  gtcagcacc  cggcatgac  aaatgcaac  120
tcacgtgcc  caagatgac  tcgccaatc  cagtgacct  gctcatcca  tatcaactg  180
accaggagt  ctgcggcaa  cgcgccatc  tcctggaga  gagacagca  agacacttc  240
gtgctgacc  aaaggagaa  tgggtccaa  acgccatga  gcacctgga  caccagacc  300
ctgccctga  tagaaatgg  ggcaagttt  agaagcgtg  ggacaatgt  acacctagg  360
tcacctcgg  caccagggg  ctgtcccca  ctgccctgg  aaagcctga  tcagccaca  420
tggaagacc  tactttgga  ccgactgct  tttcccagg  ggcccgaag  cccatgggg  480
cttcccaag  gccaccagc  gcagtgact  gatcgtctc  ctcaacttc  aaagctcag  540
atgcagggc  tgccgccaa  cctcagagc  ctggaattt  tgaggtggc  gctgtctct  600
ccaccattt  gccgagttc  gctgtctac  aatctggat  tagcctctg  gccgaggaa  660
aagctactg  atccccccc  actatagcc  tatctactc  agcgtccac  acttcaagc  720
ccaagcaga  tgttgggtc  gaaggccag  ccccatggg  ccaggagca  gactccact  780
cagagaaat  tccagggcc  gaggagaca  acccagttc  tactgatat  ttccaagac  840
gaggacctg  cagcacagt  catccctca  tggctccca  ctcctctga  aagaccccc  900
gcccggagc  ggtggcctc  ggcagccag  ctcctaagg  agaggaacc  attcatgcc  960
ctgcagatc  ccagaaact  agtgtgttt  tcactcctg  ccctgactc  caggcagcc  1020
cccggaggc  ggcagtggg  ttactggcc  ttcttggtc  actcttctg  ctgggggtg  1080
ccatgtttg  ctaccagag  ctccagggc  gtccccgca  aatggcagg  gagatggtg  1140
aaggcctcc  ctacgtccc  cgtagctgt  gcagtaact  gtacgtcct  gtgccggtg  1200
gagctgcct  cttgcctgc  tgtgtccag  gtgtgattc  gacagctgt  tggggaccc  1260
catcctcat  cccaccttc  tccacgctg  gagaatggg  atgcagaag  tagatcctc  1320
aggggccat  tgctccaac  cccgaggag  ggccctgga  gccacccta  accattatt  1380
acttatcag  gacagacag  gcaggtggc  ttccagctc  cccatattt  aaagaatcc  1440
ctgctgctg  ctggttaga  gggcccttg  catcccaaa  tctatgagc  attatttat  1500
ggattccca  ccccctgag  cacccgttt  cccgtgcgc  ccgtggtcc  cccatctta  1560
aagcagcag  caggcctct  tgcctgtcc  ctgacctcc  cgtgtctcc  ggctttgct  1620
cagtcgcca  ccctgtctc  tccccggcc  gctgcggtg  tatctatcc  ggtctctct  1680
tctcgtgta  agagccatc  ccaccatca  caccaacaa  tcgttctgt  tttgcttgc  1740
tgaggttaa  gctgtgttt  ctggagctc  ctgggacgg  agatgagct  ctgtgaggg  1800
ttaaagtgt  cctccccag  ctttgatgt  ccgtgaagc  tgctgcctc  gaaggaagg  1860
tctggtccc  actccgctg  cagcacaac  aagtgcccc  cctgtaaag  aaaagagac  1920
cggcccaga  ctggcaaaa  cccatggcc  tgacatcat  actttctct  agatctttg  1980
ccccatccc  ggatgccac  ccccccccc  agcccttat  aacatgaat  gtcactgcc  2040
ttccactgg  ctgacactt  tgtatgctg  gattctgag  gctggcaag  gatgacttg  2100
gagtgcaga  cctacccat  ggcccccaa  tggaggctg  gctggggac  tgcaggaag  2160
gaggccaac  cagaaggct  cgctgtgtt  tcactggca  ccctcccct  tgcaccaag  2220
tgacagtca  aggtctgcc  tgcctgaag  acaagccac  gaaggaaga  tatgacaag  2280
ccctgggag  ccaaggatc  agggcaaac  ctggagtgg  cacacaccc  atttcagct  2340
agggacttg  gcatgtgtg  acttgcaca  cccagatca  tcagaagct  ccaggatcc  2400
ttcctacat  tgagagcgc  gttcctgcc  aggtctcac  ttcgcctca  ttcaggcag  2460
gcagaactc  cataacatt  tccaagagc  ctgtgacgt  ttctggaag  gactctgcc  2520
tgggcacaa  gtgtctact  aagcagaga  cagcgcccc  gccccagcc  cagcgcccc  2580
gcgggagct  taccggcag  ccacgccct  ggggggagg  ccctccgtg  cagctttcc  2640
ctctgaata  ctccaaccg  cacctttgg  gcctcccag  ggcgggctt  acccagcca  2700
tgactcact  cttgatagg  ggaagctca  aacaggtgg  ctcgtccca  agtgaggaa  2760
ccagcccct  ggcgaccct  ctcttggga  gcttgtggg  ggctctggt  tggctccag  2820
gtactagtt  taggcctga  gagcagcag  ccgagtgca  tatatcctg  ttcttcggt  2880
gggagcctt  aagggttgg  acacccatg  ttggacttt  ttggttccc  cgcctcgtg  2940
gccaaaaca  tctgaggag  actttggaa  gagttggtt  ttcaagcat  attaccaat  3000
tctgtgcca  tttgtattt  actaataaa  ttttaaagt  ttgt  3044



<210> 639
<211> 393
<212> PRT
<213> Rattus norvegicus
<308> O55145
<400> 639

Met Ala Pro Ser Gln Leu Ala Trp Leu Leu Arg Leu Ala Ala Phe Phe 
  1               5                  10                  15
His Leu Cys Thr Leu Leu Ala Gly Gln His Leu Gly Met Thr Lys Cys 
             20                  25                  30
Asn Ile Thr Cys His Lys Met Thr Ser Pro Ile Pro Val Thr Leu Leu 
         35                  40                  45
Ile His Tyr Gln Leu Asn Gln Glu Ser Cys Gly Lys Arg Ala Ile Ile 
     50                  55                  60
Leu Glu Thr Arg Gln His Arg His Phe Cys Ala Asp Pro Lys Glu Lys 
 65                  70                  75                  80
Trp Val Gln Asp Ala Met Lys His Leu Asp His Gln Thr Ala Ala Leu 
                 85                  90                  95
Thr Arg Asn Gly Gly Lys Phe Glu Lys Arg Val Asp Asn Val Thr Pro 
             100                105                110
Arg Ile Thr Ser Ala Thr Arg Gly Leu Ser Pro Thr Ala Leu Ala Lys 
         115                120                125
Pro Glu Ser Ala Thr Val Glu Asp Leu Thr Leu Glu Pro Thr Ala Ile 
     130                135                140
Ser Gln Glu Ala Arg Arg Pro Met Gly Thr Ser Gln Glu Pro Pro Ala 
 145                150                155                160
Ala Val Thr Gly Ser Ser Pro Ser Thr Ser Lys Ala Gln Asp Ala Gly 
                 165                170                175
Leu Ala Ala Lys Pro Gln Ser Thr Gly Ile Ser Glu Val Ala Ala Val 
             180                185                190
Ser Thr Thr Ile Trp Pro Ser Ser Ala Val Tyr Gln Ser Gly Ser Ser 
         195                200                205
Leu Trp Ala Glu Glu Lys Ala Thr Glu Ser Pro Pro Thr Ile Ala Leu 
     210                215                220
Ser Thr Gln Ala Ser Thr Thr Ser Ser Pro Lys Gln Asn Val Gly Ser 
 225                230                235                240
Glu Gly Gln Pro Pro Trp Val Gln Glu Gln Asp Ser Thr Pro Glu Lys 
                 245                250                255
Ser Pro Gly Pro Glu Glu Thr Asn Pro Val His Thr Asp Ile Phe Gln 
             260                265                270
Asp Arg Gly Pro Gly Ser Thr Val His Pro Ser Val Ala Pro Thr Ser 
         275                280                285
Ser Glu Lys Thr Pro Ser Pro Glu Leu Val Ala Ser Gly Ser Gln Ala 
     290                295                300
Pro Lys Val Glu Glu Pro Ile His Ala Thr Ala Asp Pro Gln Lys Leu 
 305                310                315                320
Ser Val Phe Ile Thr Pro Val Pro Asp Ser Gln Ala Ala Thr Arg Arg 
                 325                330                335
Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu Phe Cys Leu Gly 
             340                345                350
Val Ala Met Phe Ala Tyr Gln Ser Leu Gln Gly Cys Pro Arg Lys Met 
         355                360                365
Ala Gly Glu Met Val Glu Gly Leu Arg Tyr Val Pro Arg Ser Cys Gly 
     370                375                380
Ser Asn Ser Tyr Val Leu Val Pro Val 
 385                390



<210> 640
<211> 3310
<212> DNA
<213> Homo sapiens
<308> U84487
<400> 640

ggcacgagg  cactgagct  tgccgcctg  ctctagccg  ctgcctggc  cccgccggg  60
ctcttgccc  ccctcagcc  tggctccga  atctctgtc  tggctgctc  gcttggcca  120
cttctgcca  ctgactgtc  tgctggctg  acagcacca  ggtgtgacg  aatgcaaca  180
cacgtgcag  aagatgaca  caaagatac  tgtagcttt  ctcatccac  atcaacaga  240
ccaggcatc  tgcggcaaa  gcgcaatca  cttggagac  agacagcac  ggctgttct  300
tgccgaccc  aaggagcaa  gggtcaagg  cgcgatgca  catctggac  gccaggctg  360
tgccctaac  cgaaatggc  gcaccttcg  gaagcagat  ggcgaggtg  agcccagga  420
cacccctgc  gccggggga  tggacgagt  tgtggtcct  gagcccgaa  ccacaggcg  480
aagcagtag  ctggagccg  ctccttctt  ccaggaagc  cagagggcc  tggggacct  540
cccagagct  ccgacgggc  tgactggtt  ctcagggac  aggctcccc  cgacgccaa  600
ggctcagga  ggagggcct  tgggcacgg  gcttttccg  gtgcctccc  tctccactg  660
cgccacgtg  cagagttct  ctccccacc  acctgggcc  agcctctgg  ctgaggcaa  720
gacctctga  gccccgtcc  cccaggacc  ctccaccca  gcctccact  cgtcctccc  780
agccccaga  gagaatgct  cgtctgaag  ccagcgtgt  tggggtcag  gacagagcc  840
caggccaga  aactctctg  agcgggagg  gatgggtcc  gtgccagcg  acacggatg  900
cttccagga  tgggggcct  gcagcatgg  ccacgtctc  gtggtccct  tctcctcag  960
agggacccc  agcagggag  cagtggctt  aggcagctg  acccctaag  ctgaggaac  1020
catccatgc  accatggac  cccagaggc  gggcgtcct  atcactcct  tccctgacg  1080
ccaggctgc  acccggagg  aggcggtgg  gctgctggc  ttccttggc  tcctcttct  1140
cctgggggt  gccatgttc  cctaccaga  cctccaggg  tgccctcga  agatggcag  1200
agagatggc  gagggcctt  gctacatcc  ccggagctg  ggtagtaat  catatgtcc  1260
ggtgcccgt  tgaactcct  tggcctgtg  ctagttgtt  gattcagac  gctgcctgg  1320
atccctcat  ctcataccc  cccccaccc  agggcctgg  ctgagctgg  atgattgga  1380
gggggaggt  ggatcctcc  ggtgcacaa  ctccaagct  ccaggcatt  cccaggagg  1440
cagccttga  cattctcca  cttccaggg  cagaggggg  ggcctccca  ctcacccca  1500
ccccaaaac  ctcctctgc  gctggctgg  tagaggttc  ctttgacgc  atcccagcc  1560
caatgaaca  ttatttatt  aatgcccag  cccttctga  ccatgctgc  ctgtgagta  1620
tacagtcct  ccatctcac  catgagcat  aggccaggc  ctctgccca  tccctgcaa  1680
ctgattgtg  ctcttggtc  tgctgcagt  gccagtcac  ccggccacc  gcggtgcta  1740
ctcccccag  cccatcctc  gtacagagc  cacgccccc  ctggtgaca  gtcttttct  1800
gcatgaggc  agtgtggtg  ttcctgggc  ctgcttcca  tgaggctct  cccttggtt  1860
ggsattgtg  gaaggggag  taagggtat  tggtgactt  cctctttgg  ctacactgt  1920
ctgagtctg  aggctgggt  ctgatccta  ttccaccat  aagccacca  catactccc  1980
tctgtgaaa  gaaagaggg  ggtaaggaa  acctgtccc  ctgacaaca  tcattgacc  2040
gaggccctt  tctccagcc  ctggatgca  cctcacagt  cttaccagc  gagcacctt  2100
gacagtccc  gccaatgga  taacttgtc  ttggaccct  aggcccaga  ggcctgcar  2160
ggagtgagt  gatagcaca  accctgccc  gtgggcccc  aaatggaaa  gggcagagc  2220
gagaccatc  ctgaaggcc  cgcccaggc  tagtcactg  gacagcccg  gctctgctt  2280
ccatcaccc  ctaagaggg  gggagggct  cagacacat  tccaagaag  ccaggaaag  2340
ctccaggag  agccacatt  ctgatgctt  ttcagagac  cctgcaggc  gccaggcca  2400
aagaccctt  tggtcccac  ccacacacg  cagattctt  cctgaggct  ggctccctt  2460
ccacctctc  cactccttg  aaacactgt  ctctgccct  caagacctt  tccttcacc  2520
ttgtcccca  cgcagacag  accagggga  ttccatgat  ttttccatg  gtcccctgt  2580
tgtttctga  agggacgct  cccgggaag  gggctggga  atgggaaag  ggaagttgt  2640
ggcataaag  caggggttc  cttttttgg  tgctgaagg  tcgagcatg  ctggatggg  2700
ctgcaccgg  tggcctggc  cctcagggt  cctggtggc  gctcacctc  cccttggat  2760
gtccccgac  cttgccgtc  acctgaggg  cctcttatg  gctgggttc  acccaggtg  2820
taggaacac  ccttcacag  tgggtgctt  gaggaagga  acccagctc  ggtccatag  2880
gagcaaaac  ctgtgctgc  ctgcccacc  tggcctctg  actcccctg  tgggtgtgg  2940
gcagcatat  caggaagct  agggccctg  ctcaggtgg  gtcactctg  cagctcaga  3000
agggtggga  tgggtccaa  gcactttgt  ctggctctt  caggctggg  gagcctttc  3060
ggggtggga  accctgtga  ggggccctg  ctcctttgt  aggaagccg  tggggccag  3120
tggtccccc  tccatggac  ttgttagtt  ctccaagca  gacatggac  aggatgatc  3180
aggaagact  tggaaagag  aggaagact  tggaaagac  tttccaacc  tcatcacca  3240
cgtctgtgc  attttgtat  ttactaata  aatttaaaa  tcttgtgaa  aaaaaaaaa  3300
aaaaaaaaaa  3310



<210> 641
<211> 397
<212> PRT
<213> Homo sapiens
<308> P78423
<400> 641

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
  1               5                  10                  15
His Leu Thr Val Leu Leu Ala Gly Gln His His Gly Val Thr Lys Cys 
             20                  25                  30
Asn Ile Thr Cys Ser Lys Met Thr Ser Lys Ile Pro Val Ala Leu Leu 
         35                  40                  45
Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 
     50                  55                  60
Leu Glu Thr Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 
 65                  70                  75                  80
Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 
                 85                  90                  95
Thr Arg Asn Gly Gly Thr Phe Glu Lys Gln Ile Gly Glu Val Lys Pro 
             100                105                110
Arg Thr Thr Pro Ala Ala Gly Gly Met Asp Glu Ser Val Val Leu Glu 
         115                120                125
Pro Glu Ala Thr Gly Glu Ser Ser Ser Leu Glu Pro Thr Pro Ser Ser 
     130                135                140
Gln Glu Ala Gln Arg Ala Leu Gly Thr Ser Pro Glu Leu Pro Thr Gly 
 145                150                155                160
Val Thr Gly Ser Ser Gly Thr Arg Leu Pro Pro Thr Pro Lys Ala Gln 
                 165                170                175
Asp Gly Gly Pro Val Gly Thr Glu Leu Phe Arg Val Pro Pro Val Ser 
             180                185                190
Thr Ala Ala Thr Trp Gln Ser Ser Ala Pro His Gln Pro Gly Pro Ser 
         195                200                205
Leu Trp Ala Glu Ala Lys Thr Ser Glu Ala Pro Ser Thr Gln Asp Pro 
     210                215                220
Ser Thr Gln Ala Ser Thr Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala 
 225                230                235                240
Pro Ser Glu Gly Gln Arg Val Trp Gly Gln Gly Gln Ser Pro Arg Pro 
                 245                250                255
Glu Asn Ser Leu Glu Arg Glu Glu Met Gly Pro Val Pro Ala His Thr 
             260                265                270
Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser Met Ala His Val Ser Val 
         275                280                285
Val Pro Val Ser Ser Glu Gly Thr Pro Ser Arg Glu Pro Val Ala Ser 
     290                295                300
Gly Ser Trp Thr Pro Lys Ala Glu Glu Pro Ile His Ala Thr Met Asp 
 305                310                315                320
Pro Gln Arg Leu Gly Val Leu Ile Thr Pro Val Pro Asp Ala Gln Ala 
                 325                330                335
Ala Thr Arg Arg Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu 
             340                345                350
Phe Cys Leu Gly Val Ala Met Phe Thr Tyr Gln Ser Leu Gln Gly Cys 
         355                360                365
Pro Arg Lys Met Ala Gly Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro 
     370                375                380
Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu Val Pro Val 
 385                390                395



<210> 642
<211> 3044
<212> DNA
<213> Rattus norvegicus
<308> AF030358
<400> 642

tgcactcca  ccatccagc  atggctccc  cacagctcg  gtggctgct  cgcctggcc  60
cgttctttc  tctgtgtac  ctgctggcg  gtcagcacc  cggcatgac  aaatgcaac  120
tcacgtgcc  caagatgac  tcgccaatc  cagtgacct  gctcatcca  tatcaactg  180
accaggagt  ctgcggcaa  cgcgccatc  tcctggaga  gagacagca  agacacttc  240
gtgctgacc  aaaggagaa  tgggtccaa  acgccatga  gcacctgga  caccagacc  300
ctgccctga  tagaaatgg  ggcaagttt  agaagcgtg  ggacaatgt  acacctagg  360
tcacctcgg  caccagggg  ctgtcccca  ctgccctgg  aaagcctga  tcagccaca  420
tggaagacc  tactttgga  ccgactgct  tttcccagg  ggcccgaag  cccatgggg  480
cttcccaag  gccaccagc  gcagtgact  gatcgtctc  ctcaacttc  aaagctcag  540
atgcagggc  tgccgccaa  cctcagagc  ctggaattt  tgaggtggc  gctgtctct  600
ccaccattt  gccgagttc  gctgtctac  aatctggat  tagcctctg  gccgaggaa  660
aagctactg  atccccccc  actatagcc  tatctactc  agcgtccac  acttcaagc  720
ccaagcaga  tgttgggtc  gaaggccag  ccccatggg  ccaggagca  gactccact  780
cagagaaat  tccagggcc  gaggagaca  acccagttc  tactgatat  ttccaagac  840
gaggacctg  cagcacagt  catccctca  tggctccca  ctcctctga  aagaccccc  900
gcccggagc  ggtggcctc  ggcagccag  ctcctaagg  agaggaacc  attcatgcc  960
ctgcagatc  ccagaaact  agtgtgttt  tcactcctg  ccctgactc  caggcagcc  1020
cccggaggc  ggcagtggg  ttactggcc  ttcttggtc  actcttctg  ctgggggtg  1080
ccatgtttg  ctaccagag  ctccagggc  gtccccgca  aatggcagg  gagatggtg  1140
aaggcctcc  ctacgtccc  cgtagctgt  gcagtaact  gtacgtcct  gtgccggtg  1200
gagctgcct  cttgcctgc  tgtgtccag  gtgtgattc  gacagctgt  tggggaccc  1260
catcctcat  cccaccttc  tccacgctg  gagaatggg  atgcagaag  tagatcctc  1320
aggggccat  tgctccaac  cccgaggag  ggccctgga  gccacccta  accattatt  1380
acttatcag  gacagacag  gcaggtggc  ttccagctc  cccatattt  aaagaatcc  1440
ctgctgctg  ctggttaga  gggcccttg  catcccaaa  tctatgagc  attatttat  1500
ggattccca  ccccctgag  cacccgttt  cccgtgcgc  ccgtggtcc  cccatctta  1560
aagcagcag  caggcctct  tgcctgtcc  ctgacctcc  cgtgtctcc  ggctttgct  1620
cagtcgcca  ccctgtctc  tccccggcc  gctgcggtg  tatctatcc  ggtctctct  1680
tctcgtgta  agagccatc  ccaccatca  caccaacaa  tcgttctgt  tttgcttgc  1740
tgaggttaa  gctgtgttt  ctggagctc  ctgggacgg  agatgagct  ctgtgaggg  1800
ttaaagtgt  cctccccag  ctttgatgt  ccgtgaagc  tgctgcctc  gaaggaagg  1860
tctggtccc  actccgctg  cagcacaac  aagtgcccc  cctgtaaag  aaaagagac  1920
cggcccaga  ctggcaaaa  cccatggcc  tgacatcat  actttctct  agatctttg  1980
ccccatccc  ggatgccac  ccccccccc  agcccttat  aacatgaat  gtcactgcc  2040
ttccactgg  ctgacactt  tgtatgctg  gattctgag  gctggcaag  gatgacttg  2100
gagtgcaga  cctacccat  ggcccccaa  tggaggctg  gctggggac  tgcaggaag  2160
gaggccaac  cagaaggct  cgctgtgtt  tcactggca  ccctcccct  tgcaccaag  2220
tgacagtca  aggtctgcc  tgcctgaag  acaagccac  gaaggaaga  tatgacaag  2280
ccctgggag  ccaaggatc  agggcaaac  ctggagtgg  cacacaccc  atttcagct  2340
agggacttg  gcatgtgtg  acttgcaca  cccagatca  tcagaagct  ccaggatcc  2400
ttcctacat  tgagagcgc  gttcctgcc  aggtctcac  ttcgcctca  ttcaggcag  2460
gcagaactc  cataacatt  tccaagagc  ctgtgacgt  ttctggaag  gactctgcc  2520
tgggcacaa  gtgtctact  aagcagaga  cagcgcccc  gccccagcc  cagcgcccc  2580
gcgggagct  taccggcag  ccacgccct  ggggggagg  ccctccgtg  cagctttcc  2640
ctctgaata  ctccaaccg  cacctttgg  gcctcccag  ggcgggctt  acccagcca  2700
tgactcact  cttgatagg  ggaagctca  aacaggtgg  ctcgtccca  agtgaggaa  2760
ccagcccct  ggcgaccct  ctcttggga  gcttgtggg  ggctctggt  tggctccag  2820
gtactagtt  taggcctga  gagcagcag  ccgagtgca  tatatcctg  ttcttcggt  2880
gggagcctt  aagggttgg  acacccatg  ttggacttt  ttggttccc  cgcctcgtg  2940
gccaaaaca  tctgaggag  actttggaa  gagttggtt  ttcaagcat  attaccaat  3000
tctgtgcca  tttgtattt  actaataaa  ttttaaagt  ttgt  3044



<210> 643
<211> 393
<212> PRT
<213> Rattus norvegicus
<308> O55145
<400> 643

Met Ala Pro Ser Gln Leu Ala Trp Leu Leu Arg Leu Ala Ala Phe Phe 
  1               5                  10                  15
His Leu Cys Thr Leu Leu Ala Gly Gln His Leu Gly Met Thr Lys Cys 
             20                  25                  30
Asn Ile Thr Cys His Lys Met Thr Ser Pro Ile Pro Val Thr Leu Leu 
         35                  40                  45
Ile His Tyr Gln Leu Asn Gln Glu Ser Cys Gly Lys Arg Ala Ile Ile 
     50                  55                  60
Leu Glu Thr Arg Gln His Arg His Phe Cys Ala Asp Pro Lys Glu Lys 
 65                  70                  75                  80
Trp Val Gln Asp Ala Met Lys His Leu Asp His Gln Thr Ala Ala Leu 
                 85                  90                  95
Thr Arg Asn Gly Gly Lys Phe Glu Lys Arg Val Asp Asn Val Thr Pro 
             100                105                110
Arg Ile Thr Ser Ala Thr Arg Gly Leu Ser Pro Thr Ala Leu Ala Lys 
         115                120                125
Pro Glu Ser Ala Thr Val Glu Asp Leu Thr Leu Glu Pro Thr Ala Ile 
     130                135                140
Ser Gln Glu Ala Arg Arg Pro Met Gly Thr Ser Gln Glu Pro Pro Ala 
 145                150                155                160
Ala Val Thr Gly Ser Ser Pro Ser Thr Ser Lys Ala Gln Asp Ala Gly 
                 165                170                175
Leu Ala Ala Lys Pro Gln Ser Thr Gly Ile Ser Glu Val Ala Ala Val 
             180                185                190
Ser Thr Thr Ile Trp Pro Ser Ser Ala Val Tyr Gln Ser Gly Ser Ser 
         195                200                205
Leu Trp Ala Glu Glu Lys Ala Thr Glu Ser Pro Pro Thr Ile Ala Leu 
     210                215                220
Ser Thr Gln Ala Ser Thr Thr Ser Ser Pro Lys Gln Asn Val Gly Ser 
 225                230                235                240
Glu Gly Gln Pro Pro Trp Val Gln Glu Gln Asp Ser Thr Pro Glu Lys 
                 245                250                255
Ser Pro Gly Pro Glu Glu Thr Asn Pro Val His Thr Asp Ile Phe Gln 
             260                265                270
Asp Arg Gly Pro Gly Ser Thr Val His Pro Ser Val Ala Pro Thr Ser 
         275                280                285
Ser Glu Lys Thr Pro Ser Pro Glu Leu Val Ala Ser Gly Ser Gln Ala 
     290                295                300
Pro Lys Val Glu Glu Pro Ile His Ala Thr Ala Asp Pro Gln Lys Leu 
 305                310                315                320
Ser Val Phe Ile Thr Pro Val Pro Asp Ser Gln Ala Ala Thr Arg Arg 
                 325                330                335
Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu Phe Cys Leu Gly 
             340                345                350
Val Ala Met Phe Ala Tyr Gln Ser Leu Gln Gly Cys Pro Arg Lys Met 
         355                360                365
Ala Gly Glu Met Val Glu Gly Leu Arg Tyr Val Pro Arg Ser Cys Gly 
     370                375                380
Ser Asn Ser Tyr Val Leu Val Pro Val 
 385                390



<210> 644
<211> 3310
<212> DNA
<213> Homo sapiens
<308> U84487
<400> 644

ggcacgagg  cactgagct  tgccgcctg  ctctagccg  ctgcctggc  cccgccggg  60
ctcttgccc  ccctcagcc  tggctccga  atctctgtc  tggctgctc  gcttggcca  120
cttctgcca  ctgactgtc  tgctggctg  acagcacca  ggtgtgacg  aatgcaaca  180
cacgtgcag  aagatgaca  caaagatac  tgtagcttt  ctcatccac  atcaacaga  240
ccaggcatc  tgcggcaaa  gcgcaatca  cttggagac  agacagcac  ggctgttct  300
tgccgaccc  aaggagcaa  gggtcaagg  cgcgatgca  catctggac  gccaggctg  360
tgccctaac  cgaaatggc  gcaccttcg  gaagcagat  ggcgaggtg  agcccagga  420
cacccctgc  gccggggga  tggacgagt  tgtggtcct  gagcccgaa  ccacaggcg  480
aagcagtag  ctggagccg  ctccttctt  ccaggaagc  cagagggcc  tggggacct  540
cccagagct  ccgacgggc  tgactggtt  ctcagggac  aggctcccc  cgacgccaa  600
ggctcagga  ggagggcct  tgggcacgg  gcttttccg  gtgcctccc  tctccactg  660
cgccacgtg  cagagttct  ctccccacc  acctgggcc  agcctctgg  ctgaggcaa  720
gacctctga  gccccgtcc  cccaggacc  ctccaccca  gcctccact  cgtcctccc  780
agccccaga  gagaatgct  cgtctgaag  ccagcgtgt  tggggtcag  gacagagcc  840
caggccaga  aactctctg  agcgggagg  gatgggtcc  gtgccagcg  acacggatg  900
cttccagga  tgggggcct  gcagcatgg  ccacgtctc  gtggtccct  tctcctcag  960
agggacccc  agcagggag  cagtggctt  aggcagctg  acccctaag  ctgaggaac  1020
catccatgc  accatggac  cccagaggc  gggcgtcct  atcactcct  tccctgacg  1080
ccaggctgc  acccggagg  aggcggtgg  gctgctggc  ttccttggc  tcctcttct  1140
cctgggggt  gccatgttc  cctaccaga  cctccaggg  tgccctcga  agatggcag  1200
agagatggc  gagggcctt  gctacatcc  ccggagctg  ggtagtaat  catatgtcc  1260
ggtgcccgt  tgaactcct  tggcctgtg  ctagttgtt  gattcagac  gctgcctgg  1320
atccctcat  ctcataccc  cccccaccc  agggcctgg  ctgagctgg  atgattgga  1380
gggggaggt  ggatcctcc  ggtgcacaa  ctccaagct  ccaggcatt  cccaggagg  1440
cagccttga  cattctcca  cttccaggg  cagaggggg  ggcctccca  ctcacccca  1500
ccccaaaac  ctcctctgc  gctggctgg  tagaggttc  ctttgacgc  atcccagcc  1560
caatgaaca  ttatttatt  aatgcccag  cccttctga  ccatgctgc  ctgtgagta  1620
tacagtcct  ccatctcac  catgagcat  aggccaggc  ctctgccca  tccctgcaa  1680
ctgattgtg  ctcttggtc  tgctgcagt  gccagtcac  ccggccacc  gcggtgcta  1740
ctcccccag  cccatcctc  gtacagagc  cacgccccc  ctggtgaca  gtcttttct  1800
gcatgaggc  agtgtggtg  ttcctgggc  ctgcttcca  tgaggctct  cccttggtt  1860
ggsattgtg  gaaggggag  taagggtat  tggtgactt  cctctttgg  ctacactgt  1920
ctgagtctg  aggctgggt  ctgatccta  ttccaccat  aagccacca  catactccc  1980
tctgtgaaa  gaaagaggg  ggtaaggaa  acctgtccc  ctgacaaca  tcattgacc  2040
gaggccctt  tctccagcc  ctggatgca  cctcacagt  cttaccagc  gagcacctt  2100
gacagtccc  gccaatgga  taacttgtc  ttggaccct  aggcccaga  ggcctgcar  2160
ggagtgagt  gatagcaca  accctgccc  gtgggcccc  aaatggaaa  gggcagagc  2220
gagaccatc  ctgaaggcc  cgcccaggc  tagtcactg  gacagcccg  gctctgctt  2280
ccatcaccc  ctaagaggg  gggagggct  cagacacat  tccaagaag  ccaggaaag  2340
ctccaggag  agccacatt  ctgatgctt  ttcagagac  cctgcaggc  gccaggcca  2400
aagaccctt  tggtcccac  ccacacacg  cagattctt  cctgaggct  ggctccctt  2460
ccacctctc  cactccttg  aaacactgt  ctctgccct  caagacctt  tccttcacc  2520
ttgtcccca  cgcagacag  accagggga  ttccatgat  ttttccatg  gtcccctgt  2580
tgtttctga  agggacgct  cccgggaag  gggctggga  atgggaaag  ggaagttgt  2640
ggcataaag  caggggttc  cttttttgg  tgctgaagg  tcgagcatg  ctggatggg  2700
ctgcaccgg  tggcctggc  cctcagggt  cctggtggc  gctcacctc  cccttggat  2760
gtccccgac  cttgccgtc  acctgaggg  cctcttatg  gctgggttc  acccaggtg  2820
taggaacac  ccttcacag  tgggtgctt  gaggaagga  acccagctc  ggtccatag  2880
gagcaaaac  ctgtgctgc  ctgcccacc  tggcctctg  actcccctg  tgggtgtgg  2940
gcagcatat  caggaagct  agggccctg  ctcaggtgg  gtcactctg  cagctcaga  3000
agggtggga  tgggtccaa  gcactttgt  ctggctctt  caggctggg  gagcctttc  3060
ggggtggga  accctgtga  ggggccctg  ctcctttgt  aggaagccg  tggggccag  3120
tggtccccc  tccatggac  ttgttagtt  ctccaagca  gacatggac  aggatgatc  3180
aggaagact  tggaaagag  aggaagact  tggaaagac  tttccaacc  tcatcacca  3240
cgtctgtgc  attttgtat  ttactaata  aatttaaaa  tcttgtgaa  aaaaaaaaa  3300
aaaaaaaaaa  3310



<210> 645
<211> 397
<212> PRT
<213> Homo sapiens
<308> P78423
<400> 645

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
  1               5                  10                  15
His Leu Thr Val Leu Leu Ala Gly Gln His His Gly Val Thr Lys Cys 
             20                  25                  30
Asn Ile Thr Cys Ser Lys Met Thr Ser Lys Ile Pro Val Ala Leu Leu 
         35                  40                  45
Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 
     50                  55                  60
Leu Glu Thr Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 
 65                  70                  75                  80
Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 
                 85                  90                  95
Thr Arg Asn Gly Gly Thr Phe Glu Lys Gln Ile Gly Glu Val Lys Pro 
             100                105                110
Arg Thr Thr Pro Ala Ala Gly Gly Met Asp Glu Ser Val Val Leu Glu 
         115                120                125
Pro Glu Ala Thr Gly Glu Ser Ser Ser Leu Glu Pro Thr Pro Ser Ser 
     130                135                140
Gln Glu Ala Gln Arg Ala Leu Gly Thr Ser Pro Glu Leu Pro Thr Gly 
 145                150                155                160
Val Thr Gly Ser Ser Gly Thr Arg Leu Pro Pro Thr Pro Lys Ala Gln 
                 165                170                175
Asp Gly Gly Pro Val Gly Thr Glu Leu Phe Arg Val Pro Pro Val Ser 
             180                185                190
Thr Ala Ala Thr Trp Gln Ser Ser Ala Pro His Gln Pro Gly Pro Ser 
         195                200                205
Leu Trp Ala Glu Ala Lys Thr Ser Glu Ala Pro Ser Thr Gln Asp Pro 
     210                215                220
Ser Thr Gln Ala Ser Thr Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala 
 225                230                235                240
Pro Ser Glu Gly Gln Arg Val Trp Gly Gln Gly Gln Ser Pro Arg Pro 
                 245                250                255
Glu Asn Ser Leu Glu Arg Glu Glu Met Gly Pro Val Pro Ala His Thr 
             260                265                270
Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser Met Ala His Val Ser Val 
         275                280                285
Val Pro Val Ser Ser Glu Gly Thr Pro Ser Arg Glu Pro Val Ala Ser 
     290                295                300
Gly Ser Trp Thr Pro Lys Ala Glu Glu Pro Ile His Ala Thr Met Asp 
 305                310                315                320
Pro Gln Arg Leu Gly Val Leu Ile Thr Pro Val Pro Asp Ala Gln Ala 
                 325                330                335
Ala Thr Arg Arg Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu 
             340                345                350
Phe Cys Leu Gly Val Ala Met Phe Thr Tyr Gln Ser Leu Gln Gly Cys 
         355                360                365
Pro Arg Lys Met Ala Gly Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro 
     370                375                380
Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu Val Pro Val 
 385                390                395



<210> 646
<211> 786
<212> DNA
<213> Rattus norvegicus
<308> AF031430
<400> 646

atgtcttac  ctccgggga  tggtgggga  cctgcccag  tggcgcaac  catctcctc  60
aacatccaa  agatcacac  gtgctccgc  gaaatacaa  ggactctga  tcaactggg  120
acacctcag  atacaccgg  gttgaggca  cagctgcag  aggagcagc  gtatactaa  180
caacttgcg  aagaaacag  taagtacat  aaggagttt  gctttctgc  caccacccc  240
agtgaacag  gtcaaagga  gatacagaa  gaccgattg  tggcagaat  caccacagc  300
ctaacaaac  ttcagaaag  gcagaggca  gctgctgag  gagagaaag  gttcgtggc  360
cgagtgcga  ccagttcca  agtatcggg  ggctttcct  aagacagct  aaaagcgaa  420
aattttgta  cttgggaaa  ccaaacaca  cctcaagtg  aagtccaag  tgaagaaat  480
acagaggat  acctccggc  cattcatga  agagagtct  caatcagac  gctggaagc  540
gacattatg  acattaacg  aatattcaa  gacttgggg  tgatgattc  tgaacaagg  600
gatgttatt  acagcatag  agccaatgt  gaaagtgcg  aagttcacg  acagcaggc  660
aaccagcag  tgtcaagag  ggcaaatta  cagcgcaaa  ccagaaaaa  cctctgcat  720
atcatttta  tcctggtgg  cggaatcgt  atcatcttc  tcatcgtat  gggtctgaa  780
ggctga  786



<210> 647
<211> 261
<212> PRT
<213> Rattus norvegicus
<308> O70257
<400> 647

Met Ser Tyr Thr Pro Gly Ile Gly Gly Asp Pro Ala Gln Leu Ala Gln 
  1               5                  10                  15
Arg Ile Ser Ser Asn Ile Gln Lys Ile Thr Gln Cys Ser Ala Glu Ile 
             20                  25                  30
Gln Arg Thr Leu Asn Gln Leu Gly Thr Pro Gln Asp Thr Pro Glu Leu 
         35                  40                  45
Arg Gln Gln Leu Gln Gln Glu Gln Gln Tyr Thr Asn Gln Leu Ala Lys 
     50                  55                  60
Glu Thr Asp Lys Tyr Ile Lys Glu Phe Gly Phe Leu Pro Thr Thr Pro 
 65                  70                  75                  80
Ser Glu Gln Arg Gln Arg Lys Ile Gln Lys Asp Arg Leu Val Ala Glu 
                 85                  90                  95
Phe Thr Thr Ala Leu Thr Asn Phe Gln Lys Val Gln Arg Gln Ala Ala 
             100                105                110
Glu Arg Glu Lys Glu Phe Val Ala Arg Val Arg Ala Ser Ser Arg Val 
         115                120                125
Ser Gly Gly Phe Pro Glu Asp Ser Ser Lys Ala Lys Asn Phe Val Ser 
     130                135                140
Trp Glu Ser Gln Thr Gln Pro Gln Val Gln Val Gln Asp Glu Glu Ile 
 145                150                155                160
Thr Glu Asp Asp Leu Arg Leu Ile His Glu Arg Glu Ser Ser Ile Arg 
                 165                170                175
Gln Leu Glu Ala Asp Ile Met Asp Ile Asn Glu Ile Phe Lys Asp Leu 
             180                185                190
Gly Met Met Ile His Glu Gln Gly Asp Val Ile Asp Ser Ile Glu Ala 
         195                200                205
Asn Val Glu Ser Ala Glu Val His Val Gln Gln Ala Asn Gln Gln Leu 
     210                215                220
Ser Arg Ala Ala Asn Tyr Gln Arg Lys Ser Arg Lys Thr Leu Cys Ile 
 225                230                235                240
Ile Ile Leu Ile Leu Val Val Gly Ile Val Ile Ile Phe Phe Ile Val 
                 245                250                255
Trp Gly Leu Lys Gly 
             260



<210> 648
<211> 1097
<212> DNA
<213> Homo sapiens
<308> BC011975
<400> 648

ccggggtag  tgggtgacg  cggtcggag  tgtaggagg  agccgtgga  gtccaggtg  60
ctgcttaga  aactgcaca  catctgatg  aattagcga  taagaacat  aaccatgtc  120
tacactcca  gagttggtg  tgaccccgc  cagttggcc  agaggatct  ttctaacat  180
cagaagatc  cacagtgtt  tgtggaaat  caaagaact  tgaatcaac  tggaacacc  240
caagattca  ctgaattga  gcaacagtt  caacagaag  agcagtata  taaccagct  300
gccaaagaa  cagataagt  cattaaaga  tttggatct  tgcccacca  ccccagtga  360
cagcgtcaa  ggaaaatac  gaaggatcg  ttagtggca  agttcacaa  atcactgac  420
aacttccag  aggtccaga  gcaggctgc  gagcgagag  aagagtttg  tgctcgagt  480
agagccagt  ccagagtgt  tggcagttt  cctgaggac  gctcaaaag  aaggaatct  540
gtatcctgg  aaagccaaa  tcaacctca  gtgcaggtg  aggatgaag  aattacaga  600
gatgacctc  gtcttattc  tgagagaga  tcttctatc  ggcaacttg  agctgatat  660
atggatatt  atgaaatat  taaagattt  ggaatgatg  ttcatgaac  aggagatgt  720
atagatagc  tagaagcca  tgtggaaaa  gcagaggtg  acgttcagc  agcaaatca  780
cagctgtca  gggcagcag  ttatcagcg  aaatccaga  aaaccctgt  catcatcat  840
cttatcctt  tcattggag  tgcgattat  agtctcatc  tatggggat  gaaccactg  900
agttataaa  gagcacact  tcgcactac  ttgtctaaa  tatgtagga  gattcctgt  960
atcatgttt  tttaattat  attttaaag  tattgtata  aggatggtt  ccatacttt  1020
ttattttta  tgggggggt  ggggtggtt  ctttggatt  aatctgata  tttctaata  1080
tgaaaaaaa  aaaaaaa  1097



<210> 649
<211> 261
<212> PRT
<213> Homo sapiens
<308> O15400
<400> 649

Met Ser Tyr Thr Pro Gly Val Gly Gly Asp Pro Ala Gln Leu Ala Gln 
  1               5                  10                  15
Arg Ile Ser Ser Asn Ile Gln Lys Ile Thr Gln Cys Ser Val Glu Ile 
             20                  25                  30
Gln Arg Thr Leu Asn Gln Leu Gly Thr Pro Gln Asp Ser Pro Glu Leu 
         35                  40                  45
Arg Gln Gln Leu Gln Gln Lys Gln Gln Tyr Thr Asn Gln Leu Ala Lys 
     50                  55                  60
Glu Thr Asp Lys Tyr Ile Lys Glu Phe Gly Ser Leu Pro Thr Thr Pro 
 65                  70                  75                  80
Ser Glu Gln Arg Gln Arg Lys Ile Gln Lys Asp Arg Leu Val Ala Glu 
                 85                  90                  95
Phe Thr Thr Ser Leu Thr Asn Phe Gln Lys Val Gln Arg Gln Ala Ala 
             100                105                110
Glu Arg Glu Lys Glu Phe Val Ala Arg Val Arg Ala Ser Ser Arg Val 
         115                120                125
Ser Gly Ser Phe Pro Glu Asp Ser Ser Lys Glu Arg Asn Leu Val Ser 
     130                135                140
Trp Glu Ser Gln Thr Gln Pro Gln Val Gln Val Gln Asp Glu Glu Ile 
 145                150                155                160
Thr Glu Asp Asp Leu Arg Leu Ile His Glu Arg Glu Ser Ser Ile Arg 
                 165                170                175
Gln Leu Glu Ala Asp Ile Met Asp Ile Asn Glu Ile Phe Lys Asp Leu 
             180                185                190
Gly Met Met Ile His Glu Gln Gly Asp Val Ile Asp Ser Ile Glu Ala 
         195                200                205
Asn Val Glu Asn Ala Glu Val His Val Gln Gln Ala Asn Gln Gln Leu 
     210                215                220
Ser Arg Ala Ala Asp Tyr Gln Arg Lys Ser Arg Lys Thr Leu Cys Ile 
 225                230                235                240
Ile Ile Leu Ile Leu Val Ile Gly Val Ala Ile Ile Ser Leu Ile Ile 
                 245                250                255
Trp Gly Leu Asn His 
             260



<210> 650
<211> 156
<212> DNA
<213> Rattus norvegicus
<308> AF054246
<400> 650

gtccttcta  tttcgaaat  gcatcttac  gctctttgg  aagaaagtt  atgatagct  60
tgaactttc  agcacctcc  aaacagaag  ctcatctgt  tcttcagtg  cacctgcat  120
aagtttgcc  ccaacctgt  gcatctacc  aagctt  156



<210> 651
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> AAC64920
<400> 651

Met Ala Gln Gln Leu Thr Gly Glu Gln Thr Leu Asp His Tyr Glu Asp 
  1               5                  10                  15
Ser Thr Gln Ala Ser Ile Phe Thr Tyr Thr Asn Ser Asn Ser Thr Arg 
             20                  25                  30
Gly Pro Phe Glu Gly Pro Asn Tyr His Ile Ala Pro Arg Trp Val Tyr 
         35                  40                  45
His Leu Thr Ser Thr Trp Met Ile Leu Val Val Ile Ala Ser Val Phe 
     50                  55                  60
Thr Asn Gly Leu Val Leu Ala Ala Thr Met Arg Phe Lys Lys Leu Arg 
 65                  70                  75                  80
His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala Val Ala Asp Leu Ala 
                 85                  90                  95
Glu Thr Ile Ile Ala Ser Thr Ile Ser Val Val Asn Gln Ile Tyr Gly 
             100                105                110
Tyr Phe Val Leu Gly His Pro Leu Cys Val Ile Glu Gly Tyr Ile Val 
         115                120                125
Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu Ala Ile Ile Ser Trp 
     130                135                140
Glu Arg Trp Leu Val Val Cys Lys Pro Phe Gly Asn Val Arg Phe Asp 
 145                150                155                160
Ala Lys Leu Ala Thr Val Gly Ile Val Phe Ser Trp Val Trp Ala Ala 
                 165                170                175
Val Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser Arg Tyr Trp Pro Tyr 
             180                185                190
Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe Ser Gly Thr Ser Tyr 
         195                200                205
Pro Gly Val Gln Ser Tyr Met Met Val Leu Met Val Thr Cys Cys Ile 
     210                215                220
Phe Pro Leu Ser Ile Ile Val Leu Cys Tyr Leu Gln Val Trp Leu Ala 
 225                230                235                240
Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser Glu Ser Thr Gln Lys 
                 245                250                255
Ala Glu Lys Glu Val Thr Arg Met Val Val Val Met Val Phe Ala Tyr 
             260                265                270
Cys Leu Cys Trp Gly Pro Tyr Thr Phe Phe Ala Cys Phe Ala Thr Ala 
         275                280                285
His Pro Gly Tyr Ala Phe His Pro Leu Val Ala Ser Leu Pro Ser Tyr 
     290                295                300
Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Ile Ile Tyr Val Phe Met 
 305                310                315                320
Asn Arg Gln Phe Arg Asn Cys Ile Leu Gln Leu Phe Gly Lys Lys Val 
                 325                330                335
Asp Asp Ser Ser Glu Leu Ser Ser Thr Ser Lys Thr Glu Val Ser Ser 
             340                345                350
Val Ser Ser Val Ser Pro Ala 
         355



<210> 652
<211> 1095
<212> DNA
<213> Homo sapiens
<308> NM_020061
<400> 652

atggcccag  agtggagcc  ccaaaggct  gcaggccgc  atccgcagg  cagctatga  60
gacagcacc  agtccagca  cttcaccta  accaacagc  actccacca  aggcccctt  120
gaaggcccg  attaccaca  cgctcccag  tgggtgtac  acctcacca  tgtctggat  180
atctttgtg  tcactgcat  cgtcttcac  aatgggctt  tgctggcgg  caccatgaa  240
ttcaagaag  tgcgccacc  gctgaactg  atcctggtg  acctggcgg  cgctgacct  300
gcagagacc  tcatcgcca  cactatcag  attgtgaac  aggtctctg  ctacttcgt  360
ctgggccac  ctatgtgtg  cctggaggg  tacaccgtc  ccctgtgtg  gatcacagg  420
ctctggtct  tggccatca  ttcctggga  aggtggctg  tggtgtgca  gccctttgg  480
aatgtgaga  ttgatgcca  gctggccat  gtgggcatt  ccttctcct  gatctggtc  540
gctgtgtgg  cagccccgc  catctttgg  tggagcagg  actggcccc  cggcctgaa  600
acttcatgc  gcccagacg  gttcagcgg  agctcgtac  ccggggtgc  gtcttacat  660
attgtcctc  tggtcacct  ctgcatcat  ccactcgct  tcatcatgc  ctgctacct  720
caagtgtgg  tggccatcc  agcggtggc  aagcagcag  aagagtctg  atccaccca  780
aaggcagag  aggaagtga  gcgcatggt  gtggtgatg  tctttgcgt  ctgcgtctg  840
tggggaccc  acaccttct  cgcatgctt  gctgctgcc  accctggtt  cgccttcca  900
cctttgatg  ctgccctgc  ggcctactt  gccaaaagt  ccactatct  caaccccgt  960
atctatgtc  ttatgaacc  gcagtttcg  aactgcatc  tgcagcttt  cgggaagaa  1020
gttgacgat  gctctgaac  ctccagcgc  tccaaaacg  aggtctcat  tgtgtcctc  1080
gtatcgcct  catga  1095



<210> 653
<211> 364
<212> PRT
<213> Homo sapiens
<308> NP_064445
<400> 653

Met Ala Gln Gln Trp Ser Leu Gln Arg Leu Ala Gly Arg His Pro Gln 
  1               5                  10                  15
Asp Ser Tyr Glu Asp Ser Thr Gln Ser Ser Ile Phe Thr Tyr Thr Asn 
             20                  25                  30
Ser Asn Ser Thr Arg Gly Pro Phe Glu Gly Pro Asn Tyr His Ile Ala 
         35                  40                  45
Pro Arg Trp Val Tyr His Leu Thr Ser Val Trp Met Ile Phe Val Val 
     50                  55                  60
Thr Ala Ser Val Phe Thr Asn Gly Leu Val Leu Ala Ala Thr Met Lys 
 65                  70                  75                  80
Phe Lys Lys Leu Arg His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala 
                 85                  90                  95
Val Ala Asp Leu Ala Glu Thr Val Ile Ala Ser Thr Ile Ser Ile Val 
             100                105                110
Asn Gln Val Ser Gly Tyr Phe Val Leu Gly His Pro Met Cys Val Leu 
         115                120                125
Glu Gly Tyr Thr Val Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu 
     130                135                140
Ala Ile Ile Ser Trp Glu Arg Trp Leu Val Val Cys Lys Pro Phe Gly 
 145                150                155                160
Asn Val Arg Phe Asp Ala Lys Leu Ala Ile Val Gly Ile Ala Phe Ser 
                 165                170                175
Trp Ile Trp Ser Ala Val Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser 
             180                185                190
Arg Tyr Trp Pro His Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe 
         195                200                205
Ser Gly Ser Ser Tyr Pro Gly Val Gln Ser Tyr Met Ile Val Leu Met 
     210                215                220
Val Thr Cys Cys Ile Ile Pro Leu Ala Ile Ile Met Leu Cys Tyr Leu 
 225                230                235                240
Gln Val Trp Leu Ala Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser 
                 245                250                255
Glu Ser Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Val Val 
             260                265                270
Met Ile Phe Ala Tyr Cys Val Cys Trp Gly Pro Tyr Thr Phe Phe Ala 
         275                280                285
Cys Phe Ala Ala Ala Asn Pro Gly Tyr Ala Phe His Pro Leu Met Ala 
     290                295                300
Ala Leu Pro Ala Tyr Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Val 
 305                310                315                320
Ile Tyr Val Phe Met Asn Arg Gln Phe Arg Asn Cys Ile Leu Gln Leu 
                 325                330                335
Phe Gly Lys Lys Val Asp Asp Gly Ser Glu Leu Ser Ser Ala Ser Lys 
             340                345                350
Thr Glu Val Ser Ser Val Ser Ser Val Ser Pro Ala 
         355                360



<210> 654
<211> 1989
<212> DNA
<213> Rattus norvegicus
<308> AF031642
<400> 654

aaaaagagg  aagacagag  cggcctaga  agcagacat  aggacaccc  tctaggcca  60
ctctgtttt  tgccttaat  ctcaaggaa  actgcaaga  catctgagg  gggctctgt  120
acagcgtca  ctccacaaa  tcatcgctg  aaagttcag  agatgggag  tctttcctg  180
tttcttact  agtgtttcc  ggtgtgagt  catcgcatt  acatcttcc  acctctgtg  240
acaaacaag  acaaggctc  aatcccctc  gtctacttc  tcagccgga  ctgcatgac  300
ggctatttt  accacttga  gtcatctaa  tagaagttc  caagaccac  aagaccaag  360
acacttcac  tgacagatg  gcgaccatc  cctgaagga  atgtctgac  acaaccgca  420
ccccccctt  ccagagcct  tttccagca  atacaagtt  tatgagtca  agctaagca  480
ccctacctg  ccttcaagc  cccaggata  acacccagc  cttcccctg  tggaaatgc  540
tgaagaaaa  gatctccga  catcggatg  agacagcca  atagtgaag  ttgaaaagc  600
caacgagcg  agtaaacgg  gagaaagcg  gttgccccg  agggcttct  caggccggg  660
agcgttcag  ctcttccaa  ctgtgagct  cctcactgg  gacatgaag  aatgcaaga  720
ctggctgaa  gataagccc  tggtccttc  gttcctaga  tgggtcctg  ggggagcag  780
tcaggtgat  tttgtcaac  accccctta  tgggctcat  atcttcata  ggctcctga  840
ccagaatcc  tggtggacg  ttgctgggg  actggggac  gtggtctca  ccttggctg  900
ccttgcctt  agccaggac  ggtcagcca  cgcctctgg  ctccatggg  acaacggga  960
gctggtggg  ctcctggtg  ctgtcttct  agagaagtt  gactactac  ggtggcttc  1020
gtttcctgt  accttcgca  ccatggcct  cccagttat  tctagtgcc  tgagcaccg  1080
cttcgccaa  tgggacctg  cagtcttca  actgccctt  aacatcgcc  taacactgt  1140
cctggcagc  acgggccac  acaaccttt  cttccccac  acgcttgtg  agcctgcgt  1200
ttcagcgcc  aacatcacc  ggtcagaga  tgagatgcc  ttgctgtta  aaaccatcc  1260
cgttggggt  ggccaggtc  acggctgtg  caacccctg  acaggcggc  tgatcctgg  1320
ggctctgtt  atctcctct  ccctcatct  tttgcacgc  gccatagga  ccattgtgg  1380
gctgctggc  gcactgacg  tggccactc  cttcgagac  atctacacg  gcctttgga  1440
ctacaactg  gtcctctcc  gtgtcgcca  tggaggcat  ttctacgta  tcacctggc  1500
gacacacct  ttggcactt  tctgtgccc  gttctgtgc  tacacggga  cggccctct  1560
caatatgat  gcagtggtt  gtgtgccac  gggcacctg  gccttctgt  tctccaccc  1620
caccttcct  ctcctcaca  gcaacaacc  tggcatcca  aagctccca  tcagcaaag  1680
cacctaccc  gaggccaac  gcatctact  cctgacagc  aaacgcagt  acgagcaga  1740
gccccccaa  ggtgactag  tcagcgcca  gccaaaatg  tctgctttg  ctgcatccc  1800
atggtctca  ctctgggcc  agcgacccg  ccagcactc  ctttcctcg  ctctccttg  1860
acctgtttc  aatcaaacc  acctattcc  ccctaatcc  gaggctgat  cgttccctc  1920
gcccagatc  ttataacaa  cccttgtag  attaaagga  gctggtacg  cataaaaaa  1980
aaaaaaaaa  1989



<210> 655
<211> 460
<212> PRT
<213> Rattus norvegicus
<308> AAD01938
<400> 655

Met Ser Asp His Pro Leu Lys Glu Met Ser Asp Asn Asn Arg Ser Pro 
  1               5                  10                  15
Pro Leu Pro Glu Pro Leu Ser Ser Arg Tyr Lys Leu Tyr Glu Ser Glu 
             20                  25                  30
Leu Ser Ser Pro Thr Trp Pro Ser Ser Ser Gln Asp Thr His Pro Ala 
         35                  40                  45
Leu Pro Leu Leu Glu Met Pro Glu Glu Lys Asp Leu Arg Ser Ser Asp 
     50                  55                  60
Glu Asp Ser His Ile Val Lys Ile Glu Lys Pro Asn Glu Arg Ser Lys 
 65                  70                  75                  80
Arg Arg Glu Ser Glu Leu Pro Arg Arg Ala Ser Ala Gly Arg Gly Ala 
                 85                  90                  95
Phe Ser Leu Phe Gln Ala Val Ser Tyr Leu Thr Gly Asp Met Lys Glu 
             100                105                110
Cys Lys Asn Trp Leu Lys Asp Lys Pro Leu Val Leu Gln Phe Leu Asp 
         115                120                125
Trp Val Leu Arg Gly Ala Ala Gln Val Met Phe Val Asn Asn Pro Leu 
     130                135                140
Ser Gly Leu Ile Ile Phe Ile Gly Leu Leu Ile Gln Asn Pro Trp Trp 
 145                150                155                160
Thr Ile Ala Gly Ala Leu Gly Thr Val Val Ser Thr Leu Ala Ala Leu 
                 165                170                175
Ala Leu Ser Gln Asp Arg Ser Ala Ile Ala Ser Gly Leu His Gly Tyr 
             180                185                190
Asn Gly Met Leu Val Gly Leu Leu Val Ala Val Phe Ser Glu Lys Leu 
         195                200                205
Asp Tyr Tyr Trp Trp Leu Leu Phe Pro Val Thr Phe Ala Ser Met Ala 
     210                215                220
Cys Pro Val Ile Ser Ser Ala Leu Ser Thr Val Phe Ala Lys Trp Asp 
 225                230                235                240
Leu Pro Val Phe Thr Leu Pro Phe Asn Ile Ala Leu Thr Leu Tyr Leu 
                 245                250                255
Ala Ala Thr Gly His Tyr Asn Leu Phe Phe Pro Thr Thr Leu Val Lys 
             260                265                270
Pro Ala Ser Ser Ala Pro Asn Ile Thr Trp Ser Glu Ile Glu Met Pro 
         275                280                285
Leu Leu Leu Gln Thr Ile Pro Val Gly Val Gly Gln Val Tyr Gly Cys 
     290                295                300
Asp Asn Pro Trp Thr Gly Gly Val Ile Leu Val Ala Leu Phe Ile Ser 
 305                310                315                320
Ser Pro Leu Ile Cys Leu His Ala Ala Ile Gly Ser Ile Val Gly Leu 
                 325                330                335
Leu Ala Ala Leu Thr Val Ala Thr Pro Phe Glu Thr Ile Tyr Thr Gly 
             340                345                350
Leu Trp Ser Tyr Asn Cys Val Leu Ser Cys Val Ala Ile Gly Gly Met 
         355                360                365
Phe Tyr Val Leu Thr Trp Gln Thr His Leu Leu Ala Leu Val Cys Ala 
     370                375                380
Leu Phe Cys Ala Tyr Thr Gly Ala Ala Leu Ser Asn Met Met Ala Val 
 385                390                395                400
Val Gly Val Pro Pro Gly Thr Trp Ala Phe Cys Leu Ser Thr Leu Thr 
                 405                410                415
Phe Leu Leu Leu Thr Ser Asn Asn Pro Gly Ile His Lys Leu Pro Leu 
             420                425                430
Ser Lys Val Thr Tyr Pro Glu Ala Asn Arg Ile Tyr Phe Leu Thr Ala 
         435                440                445
Lys Arg Ser Asp Glu Gln Lys Pro Pro Asn Gly Asp 
     450                455                460



<210> 656
<211> 4166
<212> DNA
<213> Homo sapiens
<308> NM_007163
<400> 656

ttttttttt  ttttttgag  cacagtttg  tctgtcacc  aggctggag  acactggca  60
tatcttggc  cactgcaac  tccacctcc  aggttcaag  gattcttct  tctcagcct  120
ccagtagct  ggactacaa  tgtgtgcca  cacaccctg  taatttttg  atttttagt  180
gagacgggg  ttcaccaca  tggccaggc  ggtctcgaa  ttctgacgt  aagtgatcc  240
cccgactcg  cctctcaaa  tgctgggat  acaggcgtg  gccgccgca  ccggccatt  300
gcttttgat  ttactggct  ataggtgga  gggacttgc  ttgcctcag  tgaaacttt  360
gactttgac  ttcaagtta  tactggaat  agttaagac  ttgggggac  gttgctaag  420
cacaatttt  ttttgaaat  tataaagaa  ataatatct  ggaggggcc  ggggcagaa  480
gatatggtt  ggctctgtg  ccacacctg  atatcatct  aaattgtaa  cccagtaat  540
cccatatgt  gagggcagg  cccagggca  ggtgactgg  tcatgggag  ggtttcccc  600
atgctgttc  cgtgatagt  agtgaattc  cacaagatc  gatggtttt  taagtgttt  660
gcaggttcc  gctccacac  atctctctc  tctgccgcc  tttgagaag  tccaagttt  720
cttcccctt  gccttccac  atgactgta  gtttcctga  gcctcccca  caatgtgga  780
gttccatcg  tagaagagt  gctgtgacc  gaaggaatg  ctgaccccc  cagcagtcc  840
ctcctgcca  agccacttt  cagcagata  aaactttac  aggcagagt  taccagccc  900
agctggccc  cgacatccc  ggatactca  ccagctctg  ccctcctgg  aatgcctga  960
gaaaaggat  tccggtctt  caatgaaga  agtcacatt  tgaagatcg  aaagctcaa  1020
gaaaggagt  aaaggaaag  cgacggggt  gcccatcgg  actcagcag  ccaaaggtg  1080
atctgcctc  ccaaagcag  gggctacct  acgggcgac  tgaaggagt  caggatctg  1140
ctgaaagac  agcaccttg  cctccagtt  atagactgg  tcctgagag  gaccgctca  1200
gtgatgttc  tcaacaatc  tctcagcgg  ctcatcatc  tcatagggc  gctgatcca  1260
aatccctgg  ggacaatca  tgggggcct  gggacagtg  tctcgacct  aacagctct  1320
gccttgggc  aagacaggt  tgccattgc  tcaggactc  atgggtaca  cgggatgct  1380
gtgggactg  tgatggccg  gttctcgga  aagttagac  actactggt  gcttctgtt  1440
cctgtgacc  tcacagcca  gtcctgccc  gttctttct  gtgccttga  ttccatctt  1500
agcaagtgg  acctcccgg  cttcactct  cccttcaac  ttgcagtca  cttgtacct  1560
gcagccaca  gccactaca  cctcttctt  cccacaaca  tggtagagc  tgtgtcttc  1620
gtgcccaat  tcacctgga  agagatgga  atgcccctg  tgttacaag  catccctgt  1680
ggggtcggc  aggtgtatg  ctgtgacaa  ccctggaca  gcggcgtgt  cctggtggc  1740
ctgttcatc  cctcgccac  catctgctt  catgcagcc  ttggctcaa  cgtggggct  1800
ctagcagcc  tgtcagtgg  cacaccctt  gagaccatc  acacaggcc  ctggagcta  1860
aactgcgtc  tctcctgca  cgccatcgg  ggcatgttc  atgccctca  ctggcagac  1920
cacctgctg  ccctcatct  tgccctgtt  tgtgcatac  tggaagcag  catctccaa  1980
atcatgtca  tggtgggcg  gccaccagg  acctgggcc  tctgccttg  caccatcat  2040
ttcctgctc  tgacgacaa  caacccagc  atcttcaga  tcccactca  caaagtcac  2100
taccccgag  ccaaccgca  ctactacct  acagtgaaa  gcggtgaag  agagaaggc  2160
cccagcgga  gcggtgggg  gcatccacc  acagcaggc  caaaggtgg  ggagggctc  2220
gaggctgtg  tctccaagc  caggagtgt  tttcacatc  agtggtcat  cattcggag  2280
aggagcaaa  tgtttggaa  aggcgaaca  caggaaaga  aaaacaaag  cccatttcc  2340
tatcaatac  ggaagccca  agtcgagct  cttgatctg  acaccatgg  ggagagctc  2400
gagataaaa  tggaaacaa  catttccaa  acatcctgg  ttcggagtt  catggctgc  2460
agtgggaaa  gggtgagca  agccctcag  tacatcaca  gagagatga  ggagtgtgg  2520
gagggactt  aagacaagt  cccagtgtt  cagttcttt  actgggtcc  ccgaggcac  2580
tctcaagtg  tgtttgtga  caaccccct  agcggcatc  tcatcatcc  cggcctctt  2640
atccagaac  cctggtggg  gatctcagg  tgcctgggt  ccatcatgt  caccttgac  2700
gccctcatc  tgagtcagg  caagtcggc  atcgctgca  gatttcacg  ctacaatgg  2760
gtgctggtg  ggctgctga  ggccgtgtt  tcagacaaa  gtgactact  ctggtggct  2820
ttgctaccc  tcatcatca  gtccatgtc  tgccccatc  tctccagtg  cctgggtac  2880
atcttcagc  agtgggacc  cccagtctt  acactgccc  tcaatatca  tgtgacttt  2940
tacctggca  ccacgggcc  ctacaacct  ttcttcccc  cagcgctgc  gcagcctgc  3000
tccgccatg  ccaacatca  ctggtcaga  gtccaagtg  ccttgcttt  gagagccat  3060
cccgttgga  ttggccaag  gtacggctg  gataacccc  ggactggag  catcttcct  3120
atagctctg  tcatatcct  acctctcat  tgcttgcat  cagcaattg  atccaccat  3180
gggatgcta  cagcactca  tattgcgac  ccctttgac  ccatctact  cggcctgtg  3240
ggcttcaac  gcaccctcg  atgcatagc  ataggaggc  tgttctacg  catcacctg  3300
cagacgcac  tcctcgcca  cgcctgcgc  ctgtttgct  cctacctgg  tgctgccct  3360
gctaacatg  tatctgtgt  tggattgcc  ccctgcact  ggcccttct  tctctcagc  3420
ctcaccttc  tgctcctga  gaccaataa  cccgccatc  acaagctcc  gctcagcaa  3480
gtcacctac  cagaggcca  ccgcatcta  tacctgtcc  aggagagaa  cagaagggc  3540
tcaatcata  caaagtatc  ggcctacga  gtctcctaa  tttccctgt  taaaacaca  3600
cagtgtaaa  tcaggcttc  gcacgccgt  cagatcccc  ggataagag  ccacttagc  3660
ttccctttg  tctgttctg  gactctctc  ccaaacaca  agaagcgtg  atgtagtca  3720
cattccaga  cctctcttt  ctaagatgc  caacactta  caaagatat  tttagttta  3780
actttatac  cttagcttt  ccataagag  tccctttgt  gggaacttg  cctcttctg  3840
gaaataagc  tcatcctta  agagaagtc  ccggccggg  acggtggct  acgcctgta  3900
tcccagcac  ttgggaggc  gaggcgggt  gatcacgag  tcaggagat  gagaccatc  3960
tggcgaaca  ggtgagacc  atctctact  aaaatacaa  aaattagcc  ggcatggtg  4020
cgggcacct  tattcccag  tacttggga  gctgaggca  gaaaatggc  tgaacccgg  4080
aggtggagc  tgcagtgag  caagatcac  ccactgcac  ccagcctgg  caacggatt  4140
agactctgt  tcaaaaaaa  aaaaaa  4166



<210> 657
<211> 397
<212> PRT
<213> Homo sapiens
<308> Q15849
<400> 657

Met Glu Glu Ser Ser Glu Ile Lys Val Glu Thr Asn Ile Ser Lys Thr 
  1               5                  10                  15
Ser Trp Ile Arg Ser Ser Met Ala Ala Ser Gly Lys Arg Val Ser Lys 
             20                  25                  30
Ala Leu Ser Tyr Ile Thr Gly Glu Met Lys Glu Cys Gly Glu Gly Leu 
         35                  40                  45
Lys Asp Lys Ser Pro Val Phe Gln Phe Phe Asp Trp Val Leu Arg Gly 
     50                  55                  60
Thr Ser Gln Val Met Phe Val Asn Asn Pro Leu Ser Gly Ile Leu Ile 
 65                  70                  75                  80
Ile Leu Gly Leu Phe Ile Gln Asn Pro Trp Trp Ala Ile Ser Gly Cys 
                 85                  90                  95
Leu Gly Thr Ile Met Ser Thr Leu Thr Ala Leu Ile Leu Ser Gln Asp 
             100                105                110
Lys Ser Ala Ile Ala Ala Gly Phe His Gly Tyr Asn Gly Val Leu Val 
         115                120                125
Gly Leu Leu Met Ala Val Phe Ser Asp Lys Gly Asp Tyr Tyr Trp Trp 
     130                135                140
Leu Leu Leu Pro Val Ile Ile Met Ser Met Ser Cys Pro Ile Leu Ser 
 145                150                155                160
Ser Ala Leu Gly Thr Ile Phe Ser Lys Trp Asp Leu Pro Val Phe Thr 
                 165                170                175
Leu Pro Phe Asn Ile Thr Val Thr Leu Tyr Leu Ala Ala Thr Gly His 
             180                185                190
Tyr Asn Leu Phe Phe Pro Thr Thr Leu Leu Gln Pro Ala Ser Ala Met 
         195                200                205
Pro Asn Ile Thr Trp Ser Glu Val Gln Val Pro Leu Leu Leu Arg Ala 
     210                215                220
Ile Pro Val Gly Ile Gly Gln Val Tyr Gly Cys Asp Asn Pro Trp Thr 
 225                230                235                240
Gly Gly Ile Phe Leu Ile Ala Leu Phe Ile Ser Ser Pro Leu Ile Cys 
                 245                250                255
Leu His Ala Ala Ile Gly Ser Thr Met Gly Met Leu Ala Ala Leu Thr 
             260                265                270
Ile Ala Thr Pro Phe Asp Ser Ile Tyr Phe Gly Leu Cys Gly Phe Asn 
         275                280                285
Ser Thr Leu Ala Cys Ile Ala Ile Gly Gly Met Phe Tyr Val Ile Thr 
     290                295                300
Trp Gln Thr His Leu Leu Ala Ile Ala Cys Ala Leu Phe Ala Ala Tyr 
 305                310                315                320
Leu Gly Ala Ala Leu Ala Asn Met Leu Ser Val Phe Gly Leu Pro Pro 
                 325                330                335
Cys Thr Trp Pro Phe Cys Leu Ser Ala Leu Thr Phe Leu Leu Leu Thr 
             340                345                350
Thr Asn Asn Pro Ala Ile Tyr Lys Leu Pro Leu Ser Lys Val Thr Tyr 
         355                360                365
Pro Glu Ala Asn Arg Ile Tyr Tyr Leu Ser Gln Glu Arg Asn Arg Arg 
     370                375                380
Ala Ser Ile Ile Thr Lys Tyr Gln Ala Tyr Asp Val Ser 
 385                390                395



<210> 658
<211> 828
<212> DNA
<213> Rattus norvegicus
<308> AF031657
<400> 658

ccaagccca  caggtgagg  acactggag  gaaacccta  aaatgtgag  agtgtggca  60
gggcttcac  cgggcctcc  ctcttctgg  ccatcagag  ggccacact  gaaacaagc  120
ctatcagtg  ggcgcttgc  ggaagagtt  ctgtcacag  tcggagttt  acaatcaca  180
acgagtcca  acgggagag  aaccctatg  atgtgagga  tgtgggaaa  gcttcagcc  240
ggcctccca  cttctggcc  atcagagag  ccacacggg  gagaaaccc  acaaatgta  300
cacgtgtgg  aagggattc  gccggagtt  agatcttaa  gttcattgt  gaatccaca  360
aggagagaa  ccctataaa  gtgagaggt  tggtaaagc  ttcagtcga  tctcaattc  420
ccaagtgca  cagagggtc  acagtgaag  caaaccgta  cagtgctca  agtgtggga  480
gggcttcag  gtagagtct  accttcaag  ccaccagag  tcccacgct  gagagagac  540
ctatcagtg  gaggagtgt  ggagaggct  ctgtcgggc  tccaacttt  tagctcatc  600
tggagttca  acaggagag  aaccgtatc  atgtgacgt  tgtgggaaa  gcttccggc  660
gaggtccta  ctccacgac  accacagga  ccacacggg  gagaaaccg  acagatgcg  720
ggagtgtgg  aaagtcttc  gttggagct  atacctcaa  gcccaccag  gagtccaca  780
gggagagaa  ccgtacaag  gtgaggagt  tgggaaagg  ttcagctg  828



<210> 659
<211> 275
<212> PRT
<213> Rattus norvegicus
<308> AAC53578
<400> 659

Gln Ala His Gln Val Arg His Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
  1               5                  10                  15
Glu Cys Gly Lys Gly Phe Thr Arg Ala Ser Thr Leu Leu Asp His Gln 
             20                  25                  30
Arg Gly His Thr Gly Asn Lys Pro Tyr Gln Cys Gly Ala Cys Trp Lys 
         35                  40                  45
Ser Phe Cys His Ser Ser Glu Phe Asn Asn His Ile Arg Val His Thr 
     50                  55                  60
Gly Glu Lys Pro Tyr Val Cys Glu Glu Cys Gly Lys Gly Phe Ser Gln 
 65                  70                  75                  80
Ala Ser His Leu Leu Ala His Gln Arg Gly His Thr Gly Glu Lys Pro 
                 85                  90                  95
Tyr Lys Cys Ser Thr Cys Gly Lys Gly Phe Ser Arg Ser Ser Asp Leu 
             100                105                110
Asn Val His Cys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
         115                120                125
Arg Cys Gly Lys Ala Phe Ser Arg Val Ser Ile Leu Gln Val His Gln 
     130                135                140
Arg Val His Ser Glu Asp Lys Pro Tyr Gln Cys Ser Glu Cys Gly Lys 
 145                150                155                160
Gly Phe Ser Val Glu Ser His Leu Gln Ala His Gln Arg Ser His Ala 
                 165                170                175
Gly Glu Arg Pro Tyr Gln Cys Glu Glu Cys Gly Arg Gly Phe Cys Arg 
             180                185                190
Ala Ser Asn Phe Leu Ala His Arg Gly Val His Thr Gly Glu Lys Pro 
         195                200                205
Tyr Gln Cys Asp Val Cys Gly Lys Arg Phe Arg Gln Arg Ser Tyr Leu 
     210                215                220
His Asp His His Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Glu 
 225                230                235                240
Glu Cys Gly Lys Val Phe Ser Trp Ser Ser Tyr Leu Lys Ala His Gln 
                 245                250                255
Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys 
             260                265                270
Gly Phe Ser 
         275



<210> 660
<211> 2409
<212> DNA
<213> Homo sapiens
<308> NM_003425
<400> 660

tgttttttt  ttttggcca  actctcatg  cttttttct  cttccctca  gttttctcc  60
tccctctta  gacttggca  ttctccaga  ggaggagga  aaaatgacg  agtctaagg  120
ggcagtgac  ttcaaggac  tggctgtgg  cttctctga  gaggagctg  aactgctgg  180
ccttgccca  aggaagctg  accgagatg  gatgctgga  aacttcagg  atgtggtct  240
agtggggca  cagtccaca  cagatggcc  accacagtt  gagagagaa  aaaagctgt  300
gatgatgaa  atggcaacc  agagagata  ctcctcagg  gccaagaat  taaaagaga  360
ggagactct  caagaagta  gattaaggt  cctgcctca  gaagagctt  tctgctccc  420
gatctggca  cagattaca  gagagttaa  caagtatca  gattctgtg  taaatattc  480
aagaacagg  tgccagttg  aaaaacgag  tgatttgca  tataaagat  agggattca  540
taatcagag  tcccatctt  aagttcaca  agtccacac  ggtgaaaaa  cctacaaag  600
agaacattg  gtgaaaagt  tcagctgga  ctctcatct  caaattaac  aaagggctc  660
cgcaggaga  aagccctac  aatgtgaaa  atgtgataa  gccttccgt  ggttttcaa  720
tcttcaagc  catcagaga  tccacagta  agcaaaatc  tacacaaat  atgcaagtt  780
caggagttt  agtcagagg  cacatcttc  ccatcatca  agagttccc  ctggagaga  840
tccatacaa  tatgaagag  gtgggagga  tgttgggaa  agctcacat  gtcaagctc  900
tctgatagt  catacggga  agaaaccct  taaatgtga  gagtgtggg  tgggcttca  960
tcagagatc  tatcttcaa  ttcatctga  agttcacac  ggaaagaaa  catataagt  1020
tgaagagtg  gggaagagc  tcagttggc  ttcacgact  caggctcat  agcgaatcc  1080
cactggcga  aaaccatac  aatgcaatg  atgtggcaa  agctttagt  acagctcac  1140
ccttaatat  cattgtaga  tccacacag  agagaaacc  tataagtgt  aggagtgtg  1200
gaaaggttt  agtgtgggt  cacaccttc  ggcccatca  ataagccac  ctggagaga  1260
gccatacaa  tgtgaggag  gtgggaaag  cttctgccg  gcctcaaat  tgctggacc  1320
tcaaagagg  catactgga  agaaaccgt  tcagtgtga  gcatgtggt  agggcttca  1380
tcgtagctc  gattttaac  ttcatttta  agtccatac  ggggaaaaa  cctataaat  1440
tgaggagtg  ggcaagggc  tcagccagg  ctcaaatct  ctggcccat  aaagaggcc  1500
cactggaga  aaaccctac  aatgtggta  atgtgggaa  ggcttcagt  ggagctcag  1560
tcttaatgt  cactgtaga  tccacacag  agagaaacc  tataaatgc  agaggtgtg  1620
taaggcctt  agtcagttc  ccagccttc  ggtgcatca  agagttcac  ctggagaga  1680
accatatca  tgtgcagag  gtgggaagg  cttcagtgt  ggttcacag  ttcaagccc  1740
tcagaggtg  cacactgga  agaaaccct  tcaatgtga  gagtgtggg  agggcttct  1800
tcgggcctc  aattttctg  cacatcgtg  agtccacac  ggagaaaaa  cataccgat  1860
tgatgtgtg  ggtaagcgc  tcagacaga  atcctacct  caagcccac  agagggtcc  1920
cacaggaga  agaccatac  aatgtgagg  atgtgggaa  gtcttcagc  ggagctcat  1980
ccttcaagc  catcaaaga  ttcacaccg  agaaaaacc  tacaaatgt  aggagtgtg  2040
gaagggctt  agttggagc  caagtctta  cattcatca  cgagtccat  ctgatgatg  2100
gggtgacaa  gactttcct  catcagagg  ttcacacag  aaaactcga  aaaatatgt  2160
ttactatct  agatgggtg  tgaaatatt  taataatca  agctatcat  gacaaaaca  2220
ttgttttat  gagtcagta  ttcagccag  gattgggag  ccacacagc  gagaagcct  2280
acaagagtg  agacatatg  actgcattc  gaacattga  cattagctg  tacatgcag  2340
caagaggat  aggaaggat  agtctgatc  ggagtaaat  agaagtact  agatagaaa  2400
gctgaattc  2409



<210> 661
<211> 682
<212> PRT
<213> Homo sapiens
<308> Q02386
<400> 661

Met Thr Lys Ser Lys Glu Ala Val Thr Phe Lys Asp Val Ala Val Val 
  1               5                  10                  15
Phe Ser Glu Glu Glu Leu Gln Leu Leu Asp Leu Ala Gln Arg Lys Leu 
             20                  25                  30
Tyr Arg Asp Val Met Leu Glu Asn Phe Arg Asn Val Val Ser Val Gly 
         35                  40                  45
His Gln Ser Thr Pro Asp Gly Leu Pro Gln Leu Glu Arg Glu Glu Lys 
     50                  55                  60
Leu Trp Met Met Lys Met Ala Thr Gln Arg Asp Asn Ser Ser Gly Ala 
 65                  70                  75                  80
Lys Asn Leu Lys Glu Met Glu Thr Leu Gln Glu Val Gly Leu Arg Tyr 
                 85                  90                  95
Leu Pro His Glu Glu Leu Phe Cys Ser Gln Ile Trp Gln Gln Ile Thr 
             100                105                110
Arg Glu Leu Ile Lys Tyr Gln Asp Ser Val Val Asn Ile Gln Arg Thr 
         115                120                125
Gly Cys Gln Leu Glu Lys Arg Asp Asp Leu His Tyr Lys Asp Glu Gly 
     130                135                140
Phe Ser Asn Gln Ser Ser His Leu Gln Val His Arg Val His Thr Gly 
 145                150                155                160
Glu Lys Pro Tyr Lys Gly Glu His Cys Val Lys Ser Phe Ser Trp Ser 
                 165                170                175
Ser His Leu Gln Ile Asn Gln Arg Ala His Ala Gly Glu Lys Pro Tyr 
             180                185                190
Lys Cys Glu Lys Cys Asp Asn Ala Phe Arg Arg Phe Ser Ser Leu Gln 
         195                200                205
Ala His Gln Arg Val His Ser Arg Ala Lys Ser Tyr Thr Asn Asp Ala 
     210                215                220
Ser Tyr Arg Ser Phe Ser Gln Arg Ser His Leu Pro His His Gln Arg 
 225                230                235                240
Val Pro Thr Gly Glu Asn Pro Tyr Lys Tyr Glu Glu Cys Gly Arg Asn 
                 245                250                255
Val Gly Lys Ser Ser His Cys Gln Ala Pro Leu Ile Val His Thr Gly 
             260                265                270
Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Val Gly Phe Ser Gln Arg 
         275                280                285
Ser Tyr Leu Gln Val His Leu Lys Val His Thr Gly Lys Lys Pro Tyr 
     290                295                300
Lys Cys Glu Glu Cys Gly Lys Ser Phe Ser Trp Arg Ser Arg Leu Gln 
 305                310                315                320
Ala His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Ala 
                 325                330                335
Cys Gly Lys Ser Phe Ser Tyr Ser Ser His Leu Asn Ile His Cys Arg 
             340                345                350
Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Gly 
         355                360                365
Phe Ser Val Gly Ser His Leu Gln Ala His Gln Ile Ser His Thr Gly 
     370                375                380
Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Cys Arg Ala 
 385                390                395                400
Ser Asn Leu Leu Asp His Gln Arg Gly His Thr Gly Glu Lys Pro Tyr 
                 405                410                415
Gln Cys Asp Ala Cys Gly Lys Gly Phe Ser Arg Ser Ser Asp Phe Asn 
             420                425                430
Ile His Phe Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu 
         435                440                445
Cys Gly Lys Gly Phe Ser Gln Ala Ser Asn Leu Leu Ala His Gln Arg 
     450                455                460
Gly His Thr Gly Glu Lys Pro Tyr Lys Cys Gly Thr Cys Gly Lys Gly 
 465                470                475                480
Phe Ser Arg Ser Ser Asp Leu Asn Val His Cys Arg Ile His Thr Gly 
                 485                490                495
Glu Lys Pro Tyr Lys Cys Glu Arg Cys Gly Lys Ala Phe Ser Gln Phe 
             500                505                510
Ser Ser Leu Gln Val His Gln Arg Val His Thr Gly Glu Lys Pro Tyr 
         515                520                525
Gln Cys Ala Glu Cys Gly Lys Gly Phe Ser Val Gly Ser Gln Leu Gln 
     530                535                540
Ala His Gln Arg Cys His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu 
 545                550                555                560
Cys Gly Lys Gly Phe Cys Arg Ala Ser Asn Phe Leu Ala His Arg Gly 
                 565                570                575
Val His Thr Gly Glu Lys Pro Tyr Arg Cys Asp Val Cys Gly Lys Arg 
             580                585                590
Phe Arg Gln Arg Ser Tyr Leu Gln Ala His Gln Arg Val His Thr Gly 
         595                600                605
Glu Arg Pro Tyr Lys Cys Glu Glu Cys Gly Lys Val Phe Ser Trp Ser 
     610                615                620
Ser Tyr Leu Gln Ala His Gln Arg Val His Thr Gly Glu Lys Pro Tyr 
 625                630                635                640
Lys Cys Glu Glu Cys Gly Lys Gly Phe Ser Trp Ser Ser Ser Leu Ile 
                 645                650                655
Ile His Gln Arg Val His Ala Asp Asp Glu Gly Asp Lys Asp Phe Pro 
             660                665                670
Ser Ser Glu Asp Ser His Arg Lys Thr Arg 
         675                680



<210> 662
<211> 1607
<212> DNA
<213> Rattus norvegicus
<308> AF032120
<400> 662

cctcgagcg  cggcggcgc  ggtctcccg  ccaagtccc  acttctggc  gctcatgcc  60
ctgggactg  ggcgaagga  aaaagcacc  cctctggtg  aaaatgagg  ggcggagcc  120
agccggagt  ggctgggcg  cggggagcc  gggcccctg  gtggaagtg  agcagggga  180
tcccagatg  gtttgcccc  acctcctgc  tccctccgg  ctcgcctcg  gttccatac  240
cagctggcc  acggcagcc  cacgggccg  atcgagggc  tcactaatg  caaggagct  300
tacggcaag  tcgctgagg  cttccgact  ccggctgct  aggtgatgt  ctgtaccct  360
aacacccat  aagtggata  ggacaagct  ctggggggc  agatcgggc  ggaggactt  420
atctttgcc  atgtcaagg  gcagcgcaa  gaggtggaa  tattcaagt  tgaggatgc  480
ctggggctc  ccatcaccg  caacggggc  ggctatgcc  tcattaagc  catcaagga  540
ggcagtgtg  ttgaccaca  ccagctcat  agcgtgggt  acatgattg  agccatcaa  600
gggcagagc  tgctgggct  tcggcatta  gaggttgcc  ggctcctca  agagctgcc  660
cgaggccgc  ccttcaccc  caaactcac  gaacctcgg  aggcgtttg  tatgatcag  720
cagcgttca  caggtggtc  ccctggctc  ggcccacaa  tgggcactg  ccgagggac  780
ctccggctc  gatcccggg  ccctgccac  gtggaggat  tgccgtcag  ttttgagga  840
aaggccatt  aaaaggtgg  tgacttgct  gagagctac  tggggatca  agacacaga  900
ctggctgcc  cgatggtgg  gctggggaa  gacaaaagg  acccagacg  actggcaga  960
gctctggat  aacggctcg  tgacttcgc  ttcccagat  aattcgtct  tgatgtctg  1020
ggagccatc  gggatgcca  ggttggccg  tactaagac  gggactgaa  ctggacctt  1080
agataacct  ctttgccca  ctggggttt  cagaaacca  agccaagac  tgggctgac  1140
gcttaggct  taactccgc  gcctgggga  ggcacaggc  gcaagtgcc  tgtggtcca  1200
gccccgctc  aatcagtac  gccacggtg  ccagcctgg  tggggtccc  ggccaaccc  1260
tgccgggtt  cccacctac  tcaatagag  aagcgcatg  ggagggacc  acacactag  1320
cagccagcc  cctctatcc  caacacttc  cactatcag  tggcaactg  cccttctgt  1380
cccctggcc  cagctctct  cggggtcat  acctcccta  tttactttt  ttgctttgt  1440
tttttcaag  caaagtcac  atgtagctc  ggctgtcct  gaactcctt  tgtaaacca  1500
gctggcctt  aactcacag  gatccacct  catctgcat  cacagtgct  ggaataaag  1560
tgtgcatca  cactcccaa  aaaaaaaaa  aaaaaaaaa  aaaaaaa  1607



<210> 663
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> Q9Z254
<400> 663

Met Pro Leu Gly Leu Gly Arg Arg Lys Lys Ala Pro Pro Leu Val Glu 
  1               5                  10                  15
Asn Glu Glu Ala Glu Pro Ser Arg Ser Gly Leu Gly Val Gly Glu Pro 
             20                  25                  30
Gly Pro Leu Gly Gly Ser Gly Ala Gly Glu Ser Gln Met Gly Leu Pro 
         35                  40                  45
Pro Pro Pro Ala Ser Leu Arg Pro Arg Leu Val Phe His Thr Gln Leu 
     50                  55                  60
Ala His Gly Ser Pro Thr Gly Arg Ile Glu Gly Phe Thr Asn Val Lys 
 65                  70                  75                  80
Glu Leu Tyr Gly Lys Ile Ala Glu Ala Phe Arg Leu Pro Ala Ala Glu 
                 85                  90                  95
Val Met Phe Cys Thr Leu Asn Thr His Lys Val Asp Met Asp Lys Leu 
             100                105                110
Leu Gly Gly Gln Ile Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 
         115                120                125
Gly Gln Arg Lys Glu Val Glu Val Phe Lys Ser Glu Asp Ala Leu Gly 
     130                135                140
Leu Thr Ile Thr Asp Asn Gly Ala Gly Tyr Ala Phe Ile Lys Arg Ile 
 145                150                155                160
Lys Glu Gly Ser Val Ile Asp His Ile Gln Leu Ile Ser Val Gly Asp 
                 165                170                175
Met Ile Glu Ala Ile Asn Gly Gln Ser Leu Leu Gly Cys Arg His Tyr 
             180                185                190
Glu Val Ala Arg Leu Leu Lys Glu Leu Pro Arg Gly Arg Thr Phe Thr 
         195                200                205
Leu Lys Leu Thr Glu Pro Arg Lys Ala Phe Asp Met Ile Ser Gln Arg 
     210                215                220
Ser Ser Gly Gly His Pro Gly Ser Gly Pro Gln Leu Gly Thr Gly Arg 
 225                230                235                240
Gly Thr Leu Arg Leu Arg Ser Arg Gly Pro Ala Thr Ile Glu Asp Leu 
                 245                250                255
Pro Ser Ala Phe Glu Glu Lys Ala Ile Glu Lys Val Asp Glu Leu Leu 
             260                265                270
Glu Ser Tyr Met Gly Ile Arg Asp Thr Glu Leu Ala Ala Thr Met Val 
         275                280                285
Glu Leu Gly Lys Asp Lys Arg Asn Pro Asp Glu Leu Ala Glu Ala Leu 
     290                295                300
Asp Glu Arg Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp 
 305                310                315                320
Val Trp Gly Ala Ile Gly Asp Ala Lys Val Gly Arg Tyr 
                 325                330



<210> 664
<211> 1416
<212> DNA
<213> Homo sapiens
<308> AF028824
<400> 664

ccaacgtca  ggagctgta  ggcaagatc  ccgaggcct  ccgcctgcc  actgccgag  60
tgatgttct  caccctgaa  acccacaaa  tggacatgg  caagctcct  gggggccag  120
tcgggctgg  ggacttcat  ttcgcccac  tgaaggggc  gcgcaagga  gtggaggtg  180
tcaagtcgg  ggatgcact  gggctcacc  tcacggaca  cggggctgg  tacgccttc  240
tcaagcgca  caaggaggg  agcgtgatc  accacatcc  cctcatcag  gtgggcgac  300
tgatcgagg  cattaacgg  cagagcctg  tgggctgcc  gcactacga  gtggcccgg  360
tgctcaagg  gctgccccg  ggccgtacc  tcacgctga  gctcacgga  cctcgcaag  420
ccttcgaca  gatcagcca  cgttcagcg  gtggccgcc  tggctctgg  ccacaactg  480
gcactggcc  agggaccct  cggctccga  cccggggcc  cgccacggt  gaggatctg  540
cctctgcct  tgaagagaa  gccattgag  aggtggatg  cctgctgga  agttacatg  600
gtatcaggg  cacggagct  gcagccacc  tggtggagc  gggaaagga  aaaaggaac  660
cggatgagc  ggccgaggc  ctggacgaa  ggctgggtg  ctttgcctt  cctgacgag  720
tcgtctttg  cgtctgggg  gccattggg  acgccaagg  cggccgcta  taggactgc  780
cccggaccc  gcgatgatg  cccgggcgc  acctggtgg  ggcccccag  agggacact  840
acgtcagga  ccgagcctc  agcctgagc  tagctcagc  gcccaagga  gatggtgag  900
ggaggtggg  ccaggcccc  tgccccgct  cactcggta  catcccctc  ctggttccc  960
gtctggccg  ggtccccgg  ccccctgtg  cctgttccc  acctacctc  gctgggtca  1020
gcacaggga  gggagggat  agccaaatt  ggcggccac  cccgcctcc  ccactttcc  1080
ccatcagct  ccaaactgg  ccctctgtc  ccctggggc  ttgggttct  tttgggggt  1140
atgaccttc  tagtttcct  acgcaggga  tacagggga  agggttgtc  ttcccccca  1200
caaatgcaa  aatgccctc  cccctcctg  gaggagccc  ctccctgtg  agcctgtta  1260
ctccgcatt  gacacgagt  tgctgtgaa  cccgcaacc  cctccccac  tcccatctc  1320
ccttccagg  ccatccctg  cccagagca  gagggaggg  gggacgatg  cggtgggtt  1380
ttgtatctg  atttgctgt  ttgaacata  agaatc  1416



<210> 665
<211> 333
<212> PRT
<213> Homo sapiens
<308> O14908
<400> 665

Met Pro Leu Gly Leu Gly Arg Arg Lys Lys Ala Pro Pro Leu Val Glu 
  1               5                  10                  15
Asn Glu Glu Ala Glu Pro Gly Arg Gly Gly Leu Gly Val Gly Glu Pro 
             20                  25                  30
Gly Pro Leu Gly Gly Gly Gly Ser Gly Gly Pro Gln Met Gly Leu Pro 
         35                  40                  45
Pro Pro Pro Pro Ala Leu Arg Pro Arg Leu Val Phe His Thr Gln Leu 
     50                  55                  60
Ala His Gly Ser Pro Thr Gly Arg Ile Glu Gly Phe Thr Asn Val Lys 
 65                  70                  75                  80
Glu Leu Tyr Gly Lys Ile Ala Glu Ala Phe Arg Leu Pro Thr Ala Glu 
                 85                  90                  95
Val Met Phe Cys Thr Leu Asn Thr His Lys Val Asp Met Asp Lys Leu 
             100                105                110
Leu Gly Gly Gln Ile Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 
         115                120                125
Gly Gln Arg Lys Glu Val Glu Val Phe Lys Ser Glu Asp Ala Leu Gly 
     130                135                140
Leu Thr Ile Thr Asp Asn Gly Ala Gly Tyr Ala Phe Ile Lys Arg Ile 
 145                150                155                160
Lys Glu Gly Ser Val Ile Asp His Ile His Leu Ile Ser Val Gly Asp 
                 165                170                175
Met Ile Glu Ala Ile Asn Gly Gln Ser Leu Leu Gly Cys Arg His Tyr 
             180                185                190
Glu Val Ala Arg Leu Leu Lys Glu Leu Pro Arg Gly Arg Thr Phe Thr 
         195                200                205
Leu Lys Leu Thr Glu Pro Arg Lys Ala Phe Asp Met Ile Ser Gln Arg 
     210                215                220
Ser Ala Gly Gly Arg Pro Gly Ser Gly Pro Gln Leu Gly Thr Gly Arg 
 225                230                235                240
Gly Thr Leu Arg Leu Arg Ser Arg Gly Pro Ala Thr Val Glu Asp Leu 
                 245                250                255
Pro Ser Ala Phe Glu Glu Lys Ala Ile Glu Lys Val Asp Asp Leu Leu 
             260                265                270
Glu Ser Tyr Met Gly Ile Arg Asp Thr Glu Leu Ala Ala Thr Met Val 
         275                280                285
Glu Leu Gly Lys Asp Lys Arg Asn Pro Asp Glu Leu Ala Glu Ala Leu 
     290                295                300
Asp Glu Arg Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp 
 305                310                315                320
Val Trp Gly Ala Ile Gly Asp Ala Lys Val Gly Arg Tyr 
                 325                330



<210> 666
<211> 1607
<212> DNA
<213> Rattus norvegicus
<308> AF032120
<400> 666

cctcgagcg  cggcggcgc  ggtctcccg  ccaagtccc  acttctggc  gctcatgcc  60
ctgggactg  ggcgaagga  aaaagcacc  cctctggtg  aaaatgagg  ggcggagcc  120
agccggagt  ggctgggcg  cggggagcc  gggcccctg  gtggaagtg  agcagggga  180
tcccagatg  gtttgcccc  acctcctgc  tccctccgg  ctcgcctcg  gttccatac  240
cagctggcc  acggcagcc  cacgggccg  atcgagggc  tcactaatg  caaggagct  300
tacggcaag  tcgctgagg  cttccgact  ccggctgct  aggtgatgt  ctgtaccct  360
aacacccat  aagtggata  ggacaagct  ctggggggc  agatcgggc  ggaggactt  420
atctttgcc  atgtcaagg  gcagcgcaa  gaggtggaa  tattcaagt  tgaggatgc  480
ctggggctc  ccatcaccg  caacggggc  ggctatgcc  tcattaagc  catcaagga  540
ggcagtgtg  ttgaccaca  ccagctcat  agcgtgggt  acatgattg  agccatcaa  600
gggcagagc  tgctgggct  tcggcatta  gaggttgcc  ggctcctca  agagctgcc  660
cgaggccgc  ccttcaccc  caaactcac  gaacctcgg  aggcgtttg  tatgatcag  720
cagcgttca  caggtggtc  ccctggctc  ggcccacaa  tgggcactg  ccgagggac  780
ctccggctc  gatcccggg  ccctgccac  gtggaggat  tgccgtcag  ttttgagga  840
aaggccatt  aaaaggtgg  tgacttgct  gagagctac  tggggatca  agacacaga  900
ctggctgcc  cgatggtgg  gctggggaa  gacaaaagg  acccagacg  actggcaga  960
gctctggat  aacggctcg  tgacttcgc  ttcccagat  aattcgtct  tgatgtctg  1020
ggagccatc  gggatgcca  ggttggccg  tactaagac  gggactgaa  ctggacctt  1080
agataacct  ctttgccca  ctggggttt  cagaaacca  agccaagac  tgggctgac  1140
gcttaggct  taactccgc  gcctgggga  ggcacaggc  gcaagtgcc  tgtggtcca  1200
gccccgctc  aatcagtac  gccacggtg  ccagcctgg  tggggtccc  ggccaaccc  1260
tgccgggtt  cccacctac  tcaatagag  aagcgcatg  ggagggacc  acacactag  1320
cagccagcc  cctctatcc  caacacttc  cactatcag  tggcaactg  cccttctgt  1380
cccctggcc  cagctctct  cggggtcat  acctcccta  tttactttt  ttgctttgt  1440
tttttcaag  caaagtcac  atgtagctc  ggctgtcct  gaactcctt  tgtaaacca  1500
gctggcctt  aactcacag  gatccacct  catctgcat  cacagtgct  ggaataaag  1560
tgtgcatca  cactcccaa  aaaaaaaaa  aaaaaaaaa  aaaaaaa  1607



<210> 667
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> Q9Z254
<400> 667

Met Pro Leu Gly Leu Gly Arg Arg Lys Lys Ala Pro Pro Leu Val Glu 
  1               5                  10                  15
Asn Glu Glu Ala Glu Pro Ser Arg Ser Gly Leu Gly Val Gly Glu Pro 
             20                  25                  30
Gly Pro Leu Gly Gly Ser Gly Ala Gly Glu Ser Gln Met Gly Leu Pro 
         35                  40                  45
Pro Pro Pro Ala Ser Leu Arg Pro Arg Leu Val Phe His Thr Gln Leu 
     50                  55                  60
Ala His Gly Ser Pro Thr Gly Arg Ile Glu Gly Phe Thr Asn Val Lys 
 65                  70                  75                  80
Glu Leu Tyr Gly Lys Ile Ala Glu Ala Phe Arg Leu Pro Ala Ala Glu 
                 85                  90                  95
Val Met Phe Cys Thr Leu Asn Thr His Lys Val Asp Met Asp Lys Leu 
             100                105                110
Leu Gly Gly Gln Ile Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 
         115                120                125
Gly Gln Arg Lys Glu Val Glu Val Phe Lys Ser Glu Asp Ala Leu Gly 
     130                135                140
Leu Thr Ile Thr Asp Asn Gly Ala Gly Tyr Ala Phe Ile Lys Arg Ile 
 145                150                155                160
Lys Glu Gly Ser Val Ile Asp His Ile Gln Leu Ile Ser Val Gly Asp 
                 165                170                175
Met Ile Glu Ala Ile Asn Gly Gln Ser Leu Leu Gly Cys Arg His Tyr 
             180                185                190
Glu Val Ala Arg Leu Leu Lys Glu Leu Pro Arg Gly Arg Thr Phe Thr 
         195                200                205
Leu Lys Leu Thr Glu Pro Arg Lys Ala Phe Asp Met Ile Ser Gln Arg 
     210                215                220
Ser Ser Gly Gly His Pro Gly Ser Gly Pro Gln Leu Gly Thr Gly Arg 
 225                230                235                240
Gly Thr Leu Arg Leu Arg Ser Arg Gly Pro Ala Thr Ile Glu Asp Leu 
                 245                250                255
Pro Ser Ala Phe Glu Glu Lys Ala Ile Glu Lys Val Asp Glu Leu Leu 
             260                265                270
Glu Ser Tyr Met Gly Ile Arg Asp Thr Glu Leu Ala Ala Thr Met Val 
         275                280                285
Glu Leu Gly Lys Asp Lys Arg Asn Pro Asp Glu Leu Ala Glu Ala Leu 
     290                295                300
Asp Glu Arg Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp 
 305                310                315                320
Val Trp Gly Ala Ile Gly Asp Ala Lys Val Gly Arg Tyr 
                 325                330



<210> 668
<211> 1416
<212> DNA
<213> Homo sapiens
<308> AF028824
<400> 668

ccaacgtca  ggagctgta  ggcaagatc  ccgaggcct  ccgcctgcc  actgccgag  60
tgatgttct  caccctgaa  acccacaaa  tggacatgg  caagctcct  gggggccag  120
tcgggctgg  ggacttcat  ttcgcccac  tgaaggggc  gcgcaagga  gtggaggtg  180
tcaagtcgg  ggatgcact  gggctcacc  tcacggaca  cggggctgg  tacgccttc  240
tcaagcgca  caaggaggg  agcgtgatc  accacatcc  cctcatcag  gtgggcgac  300
tgatcgagg  cattaacgg  cagagcctg  tgggctgcc  gcactacga  gtggcccgg  360
tgctcaagg  gctgccccg  ggccgtacc  tcacgctga  gctcacgga  cctcgcaag  420
ccttcgaca  gatcagcca  cgttcagcg  gtggccgcc  tggctctgg  ccacaactg  480
gcactggcc  agggaccct  cggctccga  cccggggcc  cgccacggt  gaggatctg  540
cctctgcct  tgaagagaa  gccattgag  aggtggatg  cctgctgga  agttacatg  600
gtatcaggg  cacggagct  gcagccacc  tggtggagc  gggaaagga  aaaaggaac  660
cggatgagc  ggccgaggc  ctggacgaa  ggctgggtg  ctttgcctt  cctgacgag  720
tcgtctttg  cgtctgggg  gccattggg  acgccaagg  cggccgcta  taggactgc  780
cccggaccc  gcgatgatg  cccgggcgc  acctggtgg  ggcccccag  agggacact  840
acgtcagga  ccgagcctc  agcctgagc  tagctcagc  gcccaagga  gatggtgag  900
ggaggtggg  ccaggcccc  tgccccgct  cactcggta  catcccctc  ctggttccc  960
gtctggccg  ggtccccgg  ccccctgtg  cctgttccc  acctacctc  gctgggtca  1020
gcacaggga  gggagggat  agccaaatt  ggcggccac  cccgcctcc  ccactttcc  1080
ccatcagct  ccaaactgg  ccctctgtc  ccctggggc  ttgggttct  tttgggggt  1140
atgaccttc  tagtttcct  acgcaggga  tacagggga  agggttgtc  ttcccccca  1200
caaatgcaa  aatgccctc  cccctcctg  gaggagccc  ctccctgtg  agcctgtta  1260
ctccgcatt  gacacgagt  tgctgtgaa  cccgcaacc  cctccccac  tcccatctc  1320
ccttccagg  ccatccctg  cccagagca  gagggaggg  gggacgatg  cggtgggtt  1380
ttgtatctg  atttgctgt  ttgaacata  agaatc  1416



<210> 669
<211> 333
<212> PRT
<213> Homo sapiens
<308> O14908
<400> 669

Met Pro Leu Gly Leu Gly Arg Arg Lys Lys Ala Pro Pro Leu Val Glu 
  1               5                  10                  15
Asn Glu Glu Ala Glu Pro Gly Arg Gly Gly Leu Gly Val Gly Glu Pro 
             20                  25                  30
Gly Pro Leu Gly Gly Gly Gly Ser Gly Gly Pro Gln Met Gly Leu Pro 
         35                  40                  45
Pro Pro Pro Pro Ala Leu Arg Pro Arg Leu Val Phe His Thr Gln Leu 
     50                  55                  60
Ala His Gly Ser Pro Thr Gly Arg Ile Glu Gly Phe Thr Asn Val Lys 
 65                  70                  75                  80
Glu Leu Tyr Gly Lys Ile Ala Glu Ala Phe Arg Leu Pro Thr Ala Glu 
                 85                  90                  95
Val Met Phe Cys Thr Leu Asn Thr His Lys Val Asp Met Asp Lys Leu 
             100                105                110
Leu Gly Gly Gln Ile Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 
         115                120                125
Gly Gln Arg Lys Glu Val Glu Val Phe Lys Ser Glu Asp Ala Leu Gly 
     130                135                140
Leu Thr Ile Thr Asp Asn Gly Ala Gly Tyr Ala Phe Ile Lys Arg Ile 
 145                150                155                160
Lys Glu Gly Ser Val Ile Asp His Ile His Leu Ile Ser Val Gly Asp 
                 165                170                175
Met Ile Glu Ala Ile Asn Gly Gln Ser Leu Leu Gly Cys Arg His Tyr 
             180                185                190
Glu Val Ala Arg Leu Leu Lys Glu Leu Pro Arg Gly Arg Thr Phe Thr 
         195                200                205
Leu Lys Leu Thr Glu Pro Arg Lys Ala Phe Asp Met Ile Ser Gln Arg 
     210                215                220
Ser Ala Gly Gly Arg Pro Gly Ser Gly Pro Gln Leu Gly Thr Gly Arg 
 225                230                235                240
Gly Thr Leu Arg Leu Arg Ser Arg Gly Pro Ala Thr Val Glu Asp Leu 
                 245                250                255
Pro Ser Ala Phe Glu Glu Lys Ala Ile Glu Lys Val Asp Asp Leu Leu 
             260                265                270
Glu Ser Tyr Met Gly Ile Arg Asp Thr Glu Leu Ala Ala Thr Met Val 
         275                280                285
Glu Leu Gly Lys Asp Lys Arg Asn Pro Asp Glu Leu Ala Glu Ala Leu 
     290                295                300
Asp Glu Arg Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp 
 305                310                315                320
Val Trp Gly Ala Ile Gly Asp Ala Lys Val Gly Arg Tyr 
                 325                330



<210> 670
<211> 1607
<212> DNA
<213> Rattus norvegicus
<308> AF032120
<400> 670

cctcgagcg  cggcggcgc  ggtctcccg  ccaagtccc  acttctggc  gctcatgcc  60
ctgggactg  ggcgaagga  aaaagcacc  cctctggtg  aaaatgagg  ggcggagcc  120
agccggagt  ggctgggcg  cggggagcc  gggcccctg  gtggaagtg  agcagggga  180
tcccagatg  gtttgcccc  acctcctgc  tccctccgg  ctcgcctcg  gttccatac  240
cagctggcc  acggcagcc  cacgggccg  atcgagggc  tcactaatg  caaggagct  300
tacggcaag  tcgctgagg  cttccgact  ccggctgct  aggtgatgt  ctgtaccct  360
aacacccat  aagtggata  ggacaagct  ctggggggc  agatcgggc  ggaggactt  420
atctttgcc  atgtcaagg  gcagcgcaa  gaggtggaa  tattcaagt  tgaggatgc  480
ctggggctc  ccatcaccg  caacggggc  ggctatgcc  tcattaagc  catcaagga  540
ggcagtgtg  ttgaccaca  ccagctcat  agcgtgggt  acatgattg  agccatcaa  600
gggcagagc  tgctgggct  tcggcatta  gaggttgcc  ggctcctca  agagctgcc  660
cgaggccgc  ccttcaccc  caaactcac  gaacctcgg  aggcgtttg  tatgatcag  720
cagcgttca  caggtggtc  ccctggctc  ggcccacaa  tgggcactg  ccgagggac  780
ctccggctc  gatcccggg  ccctgccac  gtggaggat  tgccgtcag  ttttgagga  840
aaggccatt  aaaaggtgg  tgacttgct  gagagctac  tggggatca  agacacaga  900
ctggctgcc  cgatggtgg  gctggggaa  gacaaaagg  acccagacg  actggcaga  960
gctctggat  aacggctcg  tgacttcgc  ttcccagat  aattcgtct  tgatgtctg  1020
ggagccatc  gggatgcca  ggttggccg  tactaagac  gggactgaa  ctggacctt  1080
agataacct  ctttgccca  ctggggttt  cagaaacca  agccaagac  tgggctgac  1140
gcttaggct  taactccgc  gcctgggga  ggcacaggc  gcaagtgcc  tgtggtcca  1200
gccccgctc  aatcagtac  gccacggtg  ccagcctgg  tggggtccc  ggccaaccc  1260
tgccgggtt  cccacctac  tcaatagag  aagcgcatg  ggagggacc  acacactag  1320
cagccagcc  cctctatcc  caacacttc  cactatcag  tggcaactg  cccttctgt  1380
cccctggcc  cagctctct  cggggtcat  acctcccta  tttactttt  ttgctttgt  1440
tttttcaag  caaagtcac  atgtagctc  ggctgtcct  gaactcctt  tgtaaacca  1500
gctggcctt  aactcacag  gatccacct  catctgcat  cacagtgct  ggaataaag  1560
tgtgcatca  cactcccaa  aaaaaaaaa  aaaaaaaaa  aaaaaaa  1607



<210> 671
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> Q9Z254
<400> 671

Met Pro Leu Gly Leu Gly Arg Arg Lys Lys Ala Pro Pro Leu Val Glu 
  1               5                  10                  15
Asn Glu Glu Ala Glu Pro Ser Arg Ser Gly Leu Gly Val Gly Glu Pro 
             20                  25                  30
Gly Pro Leu Gly Gly Ser Gly Ala Gly Glu Ser Gln Met Gly Leu Pro 
         35                  40                  45
Pro Pro Pro Ala Ser Leu Arg Pro Arg Leu Val Phe His Thr Gln Leu 
     50                  55                  60
Ala His Gly Ser Pro Thr Gly Arg Ile Glu Gly Phe Thr Asn Val Lys 
 65                  70                  75                  80
Glu Leu Tyr Gly Lys Ile Ala Glu Ala Phe Arg Leu Pro Ala Ala Glu 
                 85                  90                  95
Val Met Phe Cys Thr Leu Asn Thr His Lys Val Asp Met Asp Lys Leu 
             100                105                110
Leu Gly Gly Gln Ile Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 
         115                120                125
Gly Gln Arg Lys Glu Val Glu Val Phe Lys Ser Glu Asp Ala Leu Gly 
     130                135                140
Leu Thr Ile Thr Asp Asn Gly Ala Gly Tyr Ala Phe Ile Lys Arg Ile 
 145                150                155                160
Lys Glu Gly Ser Val Ile Asp His Ile Gln Leu Ile Ser Val Gly Asp 
                 165                170                175
Met Ile Glu Ala Ile Asn Gly Gln Ser Leu Leu Gly Cys Arg His Tyr 
             180                185                190
Glu Val Ala Arg Leu Leu Lys Glu Leu Pro Arg Gly Arg Thr Phe Thr 
         195                200                205
Leu Lys Leu Thr Glu Pro Arg Lys Ala Phe Asp Met Ile Ser Gln Arg 
     210                215                220
Ser Ser Gly Gly His Pro Gly Ser Gly Pro Gln Leu Gly Thr Gly Arg 
 225                230                235                240
Gly Thr Leu Arg Leu Arg Ser Arg Gly Pro Ala Thr Ile Glu Asp Leu 
                 245                250                255
Pro Ser Ala Phe Glu Glu Lys Ala Ile Glu Lys Val Asp Glu Leu Leu 
             260                265                270
Glu Ser Tyr Met Gly Ile Arg Asp Thr Glu Leu Ala Ala Thr Met Val 
         275                280                285
Glu Leu Gly Lys Asp Lys Arg Asn Pro Asp Glu Leu Ala Glu Ala Leu 
     290                295                300
Asp Glu Arg Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp 
 305                310                315                320
Val Trp Gly Ala Ile Gly Asp Ala Lys Val Gly Arg Tyr 
                 325                330



<210> 672
<211> 1416
<212> DNA
<213> Homo sapiens
<308> AF028824
<400> 672

ccaacgtca  ggagctgta  ggcaagatc  ccgaggcct  ccgcctgcc  actgccgag  60
tgatgttct  caccctgaa  acccacaaa  tggacatgg  caagctcct  gggggccag  120
tcgggctgg  ggacttcat  ttcgcccac  tgaaggggc  gcgcaagga  gtggaggtg  180
tcaagtcgg  ggatgcact  gggctcacc  tcacggaca  cggggctgg  tacgccttc  240
tcaagcgca  caaggaggg  agcgtgatc  accacatcc  cctcatcag  gtgggcgac  300
tgatcgagg  cattaacgg  cagagcctg  tgggctgcc  gcactacga  gtggcccgg  360
tgctcaagg  gctgccccg  ggccgtacc  tcacgctga  gctcacgga  cctcgcaag  420
ccttcgaca  gatcagcca  cgttcagcg  gtggccgcc  tggctctgg  ccacaactg  480
gcactggcc  agggaccct  cggctccga  cccggggcc  cgccacggt  gaggatctg  540
cctctgcct  tgaagagaa  gccattgag  aggtggatg  cctgctgga  agttacatg  600
gtatcaggg  cacggagct  gcagccacc  tggtggagc  gggaaagga  aaaaggaac  660
cggatgagc  ggccgaggc  ctggacgaa  ggctgggtg  ctttgcctt  cctgacgag  720
tcgtctttg  cgtctgggg  gccattggg  acgccaagg  cggccgcta  taggactgc  780
cccggaccc  gcgatgatg  cccgggcgc  acctggtgg  ggcccccag  agggacact  840
acgtcagga  ccgagcctc  agcctgagc  tagctcagc  gcccaagga  gatggtgag  900
ggaggtggg  ccaggcccc  tgccccgct  cactcggta  catcccctc  ctggttccc  960
gtctggccg  ggtccccgg  ccccctgtg  cctgttccc  acctacctc  gctgggtca  1020
gcacaggga  gggagggat  agccaaatt  ggcggccac  cccgcctcc  ccactttcc  1080
ccatcagct  ccaaactgg  ccctctgtc  ccctggggc  ttgggttct  tttgggggt  1140
atgaccttc  tagtttcct  acgcaggga  tacagggga  agggttgtc  ttcccccca  1200
caaatgcaa  aatgccctc  cccctcctg  gaggagccc  ctccctgtg  agcctgtta  1260
ctccgcatt  gacacgagt  tgctgtgaa  cccgcaacc  cctccccac  tcccatctc  1320
ccttccagg  ccatccctg  cccagagca  gagggaggg  gggacgatg  cggtgggtt  1380
ttgtatctg  atttgctgt  ttgaacata  agaatc  1416



<210> 673
<211> 333
<212> PRT
<213> Homo sapiens
<308> O14908
<400> 673

Met Pro Leu Gly Leu Gly Arg Arg Lys Lys Ala Pro Pro Leu Val Glu 
  1               5                  10                  15
Asn Glu Glu Ala Glu Pro Gly Arg Gly Gly Leu Gly Val Gly Glu Pro 
             20                  25                  30
Gly Pro Leu Gly Gly Gly Gly Ser Gly Gly Pro Gln Met Gly Leu Pro 
         35                  40                  45
Pro Pro Pro Pro Ala Leu Arg Pro Arg Leu Val Phe His Thr Gln Leu 
     50                  55                  60
Ala His Gly Ser Pro Thr Gly Arg Ile Glu Gly Phe Thr Asn Val Lys 
 65                  70                  75                  80
Glu Leu Tyr Gly Lys Ile Ala Glu Ala Phe Arg Leu Pro Thr Ala Glu 
                 85                  90                  95
Val Met Phe Cys Thr Leu Asn Thr His Lys Val Asp Met Asp Lys Leu 
             100                105                110
Leu Gly Gly Gln Ile Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 
         115                120                125
Gly Gln Arg Lys Glu Val Glu Val Phe Lys Ser Glu Asp Ala Leu Gly 
     130                135                140
Leu Thr Ile Thr Asp Asn Gly Ala Gly Tyr Ala Phe Ile Lys Arg Ile 
 145                150                155                160
Lys Glu Gly Ser Val Ile Asp His Ile His Leu Ile Ser Val Gly Asp 
                 165                170                175
Met Ile Glu Ala Ile Asn Gly Gln Ser Leu Leu Gly Cys Arg His Tyr 
             180                185                190
Glu Val Ala Arg Leu Leu Lys Glu Leu Pro Arg Gly Arg Thr Phe Thr 
         195                200                205
Leu Lys Leu Thr Glu Pro Arg Lys Ala Phe Asp Met Ile Ser Gln Arg 
     210                215                220
Ser Ala Gly Gly Arg Pro Gly Ser Gly Pro Gln Leu Gly Thr Gly Arg 
 225                230                235                240
Gly Thr Leu Arg Leu Arg Ser Arg Gly Pro Ala Thr Val Glu Asp Leu 
                 245                250                255
Pro Ser Ala Phe Glu Glu Lys Ala Ile Glu Lys Val Asp Asp Leu Leu 
             260                265                270
Glu Ser Tyr Met Gly Ile Arg Asp Thr Glu Leu Ala Ala Thr Met Val 
         275                280                285
Glu Leu Gly Lys Asp Lys Arg Asn Pro Asp Glu Leu Ala Glu Ala Leu 
     290                295                300
Asp Glu Arg Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp 
 305                310                315                320
Val Trp Gly Ala Ile Gly Asp Ala Lys Val Gly Arg Tyr 
                 325                330



<210> 674
<211> 4358
<212> DNA
<213> Rattus norvegicus
<308> AF032666
<400> 674

actgctgcg  cccggagcg  gttggcccg  acctgacgc  gcctgcaag  tgcaggaca  60
agggctgga  atggcagat  ccaggagct  gcagccagc  cagccgaat  gtgtctcca  120
ctggagtgc  ggagagaga  actgaaaac  aaaaaggtt  cttttataa  tggaacagg  180
gtttgctgc  caaagtaca  tgtctcgat  ccggcagcc  ccacttgtg  caggcatct  240
tccaaatga  gggattcct  ggaccaaag  cacaattag  ggggagaat  tgggtactg  300
tcccactga  cttataggc  tgacaattt  tggacataa  tgcctcctc  cggcagaat  360
gatgtctgc  agtaaaatt  tctgtcgag  gggacaagc  aaaaatgac  aaggagaca  420
tattgtcac  accaagtca  ggggcagag  aacctcaac  gtctctttt  agctactca  480
acctgaaaa  ataggcatt  tggatcagt  tgcagtgtg  gtggatgag  tgaattatt  540
tgatatgcg  actgacagg  ataagggga  tcccccctt  tcacttcgt  ctgcgaatc  600
tctcggcat  gaaattgag  agtgtaaac  tcctcagaa  aacttagaa  tgttattcc  660
tggcatgag  gctgatttt  cgagtgaga  tttttcagc  gcctggtat  tcatagaga  720
ccactccaa  accagtttt  agcagctca  gatggcagt  accaacctc  aaaggcagg  780
caacaagaa  agcgagggt  gtctagcgt  cgtgaaggg  ggcctcagt  ccttctttg  840
agctcaaga  gctctctca  ctatccatc  aaaactaga  gcagacgga  cagaaaaag  900
agaaggatc  atgacacag  aattggaga  tgtcctcaa  agagcaagt  atactgctg  960
cacattgtt  caagaagtg  taggtcgga  agacaaggc  gattccact  ggaatgcac  1020
caacgtgct  cagcggttt  aatttctct  caaccttcc  ctcaatatc  aacggaaca  1080
tcaaaaggg  gattatgat  tggttatta  tgattatga  aaagccaaa  cgctctttg  1140
gaaaacgga  gtgcaagtt  tcaagaaat  ttatgctga  gtagaggca  gaattgaag  1200
tctaagaga  ttacttcta  agaaactgc  cgagactcc  tcaacctta  atgaccaga  1260
gcgttacat  aggtatctt  ctgacctcc  tgctcctgg  gatcctgct  ggcagtgta  1320
cggagctca  cacaagtgg  ccctcaaac  catgcaaga  tgcaaagaa  gccacatga  1380
gagcctgaa  ggtaaccca  gcccacaca  ccccatgct  gacctagat  atgatgccc  1440
cccctctgt  ttgggccat  tcagtcaga  agcatcact  aagagaggc  gcagcttcc  1500
gtctggtcg  gatgacaca  ggaggtaca  gacgcccca  agagtggca  ttgttgaaa  1560
attaacgaa  cttgtgtta  gtcagctgc  taacttctg  aaactctgg  tttcatatg  1620
taatggaag  ctgttcagt  agacagctg  gaagtcagg  cagattgaa  gatcaaaga  1680
tgtgaggca  agacaaaat  atttcaaga  aatgattca  gaagtaatg  actccctgg  1740
gaagttgat  cggggagcc  tgctcccat  cagcctccg  gaaggggat  ggagacagt  1800
tggcggctg  gaggtgcag  cagagctct  ggggcagtg  ctcgcacac  ttatccaga  1860
cataaggct  acatatgaa  cactgaccg  tctggagat  cccaatgac  tgttacaga  1920
tatccagga  ctgattttg  atctccgta  acattgcat  atggtgacg  tgcaacata  1980
agctgaaga  ataaagaga  tagctgaaa  agaagattg  attgttgat  acgaaggac  2040
gacttccct  ccatgtcag  ttgaacaga  cattgttca  tccctgcag  cgttgaagg  2100
tgttgtgga  tgcaaacct  gagaagcca  tgtctttca  cagcctaaa  cccaggagg  2160
ggtttgcca  ttgtgcatc  gtatcatgc  ggtttttat  tactgcctg  aacaactga  2220
caccaagcc  gatgcggac  tagatacta  tcatctttc  gttgatgtt  cttctcctg  2280
tttgtttgg  agcatccat  aagacttcg  tttgacttc  gagcagagg  ttttgatag  2340
cctgagtaa  tgctgctat  tagaacgtc  caccttcct  aacatagca  aacattttg  2400
aaagcacaa  ttccaggga  tagaaaaaa  aacacaggt  agtatggca  cactgaaag  2460
actggatca  cgactcttt  aaaattaca  tgagctaaa  gcagatcct  ttgttggat  2520
cttggaaac  gggatatat  caggctatt  tgattggaa  gactgtctg  ctccagcag  2580
tgtcagaaa  tatttaaaa  aagcactgg  gaatataat  gctgtgcat  cagaggtgt  2640
cactatttc  aaagaactg  tgccccggg  cctggccag  gtgatagaa  cagtctctg  2700
agagctgag  cggctgatg  agtgtgtct  atccttcag  agaaatgga  cgctgcagg  2760
cagacttga  atctgtgct  tgagggaca  tgtagccat  tacctgacc  cggagagca  2820
gtctagttt  aaacaggcc  tggaggccc  gcctcagct  gcaagtggt  cagacaaaa  2880
gctactgga  gagctgctc  acaagttca  gagcagtat  cacttgcag  tcacctgct  2940
ccaagctgc  tctccaaca  tgatgaaga  atagacaca  acagagatc  cagtccaag  3000
actgcattt  ccttctctc  tttccccag  atggtggtg  agaaagatg  tgatgggta  3060
ttaatttca  ccgatttag  ctaccatac  attttgtta  tactagctt  ggtcctgta  3120
catactctt  aaaatgttt  ttcttagct  tatgtttct  ggtgtgagt  ttgagagct  3180
ctccagcat  gcccaaagc  gccnatggt  tgtgtgaat  tgctncgca  tggcgctct  3240
cctggcctc  gtgttggca  tttccagcc  aggggagga  atgaagtca  agcttttgg  3300
gctgtcata  actttaaac  caccatttc  aacaagtgg  tctaggtgc  ctctctctc  3360
ctctctctc  ctctctctc  ctctctctg  aaagaaaaa  ataaaaatg  taaaatctg  3420
gatgcagaa  tccctggat  aactctgaa  ttcatagtc  ggctttcat  tttcccagt  3480
ttcaacacg  aagcttctg  ttctcaccc  taagttgat  catcgttgt  gggagggtt  3540
acaaggacc  gaatgtgga  gccctgtca  acccgcaag  cctgtggca  gcttgtggt  3600
ttcaatgca  cctaaagat  aagccaggc  cctcccctc  cgcaggtta  tcccctctg  3660
tactttcca  acttcgaaa  gtcttgctc  atagctgga  agatggtgc  ctggcacag  3720
ctgtgtttt  taaagatta  aggtgcctc  gtgaccagg  attgagcag  gactcactg  3780
tcactggct  gcacagtag  atctggtca  tgcgacctg  aagcagctt  tacctcact  3840
catctgacc  tagcttcag  tctggttca  tccagacag  tctgtggcg  ctttctttc  3900
gttgacaaa  ttcctgtca  ttttagttc  ggtaattcc  gagcacagc  tatgcacac  3960
atggattat  tgaggttaa  aacagtgtg  ttatttatc  cagtaactg  aagtacaaa  4020
ttaatcctt  gtttgcaaa  tatgtatgt  cagcattgt  tcctcagtg  actggtatt  4080
catctggca  agccaaact  aattccaag  cagaagtac  caactattg  ttgtttaaa  4140
acctaacaa  tacactaca  aaagccagt  gtcttcctt  tctgtaaaa  ctctaagtg  4200
ctttatttc  ccatttttt  ttagctctg  aattgttta  attcctagt  ttaaaatcc  4260
aaataaata  tggtgttct  tctttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  4320
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4358



<210> 675
<211> 924
<212> PRT
<213> Rattus norvegicus
<308> AAC01578
<400> 675

Met Ser Arg Ser Arg Gln Pro Pro Leu Val Thr Gly Ile Ser Pro Asn 
  1               5                  10                  15
Glu Gly Ile Pro Trp Thr Lys Val Thr Ile Arg Gly Glu Asn Leu Gly 
             20                  25                  30
Thr Gly Pro Thr Asp Leu Ile Gly Leu Thr Ile Cys Gly His Asn Cys 
         35                  40                  45
Leu Leu Thr Ala Glu Trp Met Ser Ala Ser Lys Ile Val Cys Arg Val 
     50                  55                  60
Gly Gln Ala Lys Asn Asp Lys Gly Asp Ile Ile Val Thr Thr Lys Ser 
 65                  70                  75                  80
Gly Gly Arg Gly Thr Ser Thr Val Ser Phe Lys Leu Leu Lys Pro Glu 
                 85                  90                  95
Lys Ile Gly Ile Leu Asp Gln Ser Ala Val Trp Val Asp Glu Met Asn 
             100                105                110
Tyr Tyr Asp Met Arg Thr Asp Arg Asn Lys Gly Ile Pro Pro Leu Ser 
         115                120                125
Leu Arg Pro Ala Asn Pro Leu Gly Ile Glu Ile Glu Lys Cys Lys Leu 
     130                135                140
Pro Gln Lys Asn Leu Glu Val Leu Phe His Gly Met Ser Ala Asp Phe 
 145                150                155                160
Thr Ser Glu Asn Phe Ser Ala Ala Trp Tyr Leu Ile Glu Asn His Ser 
                 165                170                175
Asn Thr Ser Phe Glu Gln Leu Lys Met Ala Val Thr Asn Leu Lys Arg 
             180                185                190
Gln Ala Asn Lys Lys Ser Glu Gly Ser Leu Ala Tyr Val Lys Gly Gly 
         195                200                205
Leu Ser Thr Phe Phe Glu Ala Gln Asp Ala Leu Ser Ala Ile His Gln 
     210                215                220
Lys Leu Glu Ala Asp Gly Thr Glu Lys Val Glu Gly Ser Met Thr Gln 
 225                230                235                240
Lys Leu Glu Asn Val Leu Asn Arg Ala Ser Asn Thr Ala Asp Thr Leu 
                 245                250                255
Phe Gln Glu Val Leu Gly Arg Lys Asp Lys Ala Asp Ser Thr Arg Asn 
             260                265                270
Ala Leu Asn Val Leu Gln Arg Phe Lys Phe Leu Phe Asn Leu Pro Leu 
         275                280                285
Asn Ile Lys Arg Asn Ile Gln Lys Gly Asp Tyr Asp Val Val Ile Asn 
     290                295                300
Asp Tyr Glu Lys Ala Lys Ser Leu Phe Gly Lys Thr Glu Val Gln Val 
 305                310                315                320
Phe Lys Lys Tyr Tyr Ala Glu Val Glu Ala Gly Ile Glu Asp Leu Arg 
                 325                330                335
Glu Leu Leu Leu Lys Lys Leu Leu Glu Thr Pro Ser Thr Leu His Asp 
             340                345                350
Gln Lys Arg Tyr Ile Arg Tyr Leu Ser Asp Leu His Ala Pro Gly Asp 
         355                360                365
Pro Ala Trp Gln Cys Ile Gly Ala Gln His Lys Trp Thr Leu Lys Leu 
     370                375                380
Met Gln Asp Cys Lys Glu Gly His Met Lys Ser Leu Lys Gly Asn Pro 
 385                390                395                400
Gly Pro His Ser Pro Met Leu Asp Leu Asp Asn Asp Ala Arg Pro Ser 
                 405                410                415
Val Leu Gly His Leu Ser Gln Thr Ala Ser Leu Lys Arg Gly Ser Ser 
             420                425                430
Phe Gln Ser Gly Arg Asp Asp Thr Trp Arg Tyr Lys Thr Pro His Arg 
         435                440                445
Val Ala Phe Val Glu Lys Leu Thr Lys Leu Val Leu Ser Gln Leu Pro 
     450                455                460
Asn Phe Trp Lys Leu Trp Ile Ser Tyr Val Asn Gly Ser Leu Phe Ser 
 465                470                475                480
Glu Thr Ala Glu Lys Ser Gly Gln Ile Glu Arg Ser Lys Asn Val Arg 
                 485                490                495
Gln Arg Gln Asn Asp Phe Lys Lys Met Ile Gln Glu Val Met His Ser 
             500                505                510
Leu Val Lys Leu Ile Arg Gly Ala Leu Leu Pro Phe Ser Leu Arg Glu 
         515                520                525
Gly Asp Gly Arg Gln Tyr Gly Gly Trp Glu Val Gln Ala Glu Leu Ser 
     530                535                540
Gly Gln Trp Leu Ala His Val Ile Gln Thr Ile Arg Leu Thr Tyr Glu 
 545                550                555                560
Ser Leu Thr Ala Leu Glu Ile Pro Asn Asp Met Leu Gln Ile Ile Gln 
                 565                570                575
Asp Leu Ile Leu Asp Leu Arg Ile His Cys Ile Met Val Thr Leu Gln 
             580                585                590
His Thr Ala Glu Glu Ile Lys Arg Leu Ala Glu Lys Glu Asp Trp Ile 
         595                600                605
Val Asp Asn Glu Gly Leu Thr Ser Leu Pro Cys Gln Phe Glu Gln Ser 
     610                615                620
Ile Val His Ser Leu Gln Ser Leu Lys Gly Val Val Asp Cys Lys Pro 
 625                630                635                640
Gly Glu Ala Ser Val Phe Gln Gln Pro Lys Thr Gln Glu Glu Val Cys 
                 645                650                655
Gln Leu Cys Ile Ser Ile Met Gln Val Phe Ile Tyr Cys Leu Glu Gln 
             660                665                670
Leu Ser Thr Lys Pro Asp Ala Asp Ile Asp Thr Thr His Leu Ser Val 
         675                680                685
Asp Val Ser Ser Pro Asp Leu Phe Gly Ser Ile His Glu Asp Phe Gly 
     690                695                700
Leu Thr Ser Glu Gln Arg Leu Leu Ile Val Leu Ser Asn Cys Cys Tyr 
 705                710                715                720
Leu Glu Arg His Thr Phe Leu Asn Ile Ala Glu His Phe Glu Lys His 
                 725                730                735
Asn Phe Gln Gly Ile Glu Lys Ile Thr Gln Val Ser Met Ala Ser Leu 
             740                745                750
Lys Glu Leu Asp Gln Arg Leu Phe Glu Asn Tyr Ile Glu Leu Lys Ala 
         755                760                765
Asp Pro Ile Val Gly Ser Leu Glu Thr Gly Ile Tyr Ala Gly Tyr Phe 
     770                775                780
Asp Trp Lys Asp Cys Leu Pro Pro Ala Gly Val Arg Asn Tyr Leu Lys 
 785                790                795                800
Glu Ala Leu Val Asn Ile Ile Ala Val His Ala Glu Val Phe Thr Ile 
                 805                810                815
Ser Lys Glu Leu Val Pro Arg Val Leu Ala Arg Val Ile Glu Ala Val 
             820                825                830
Ser Glu Glu Leu Ser Arg Leu Met Gln Cys Val Ser Ser Phe Ser Arg 
         835                840                845
Asn Gly Ala Leu Gln Ala Arg Leu Glu Ile Cys Ala Leu Arg Asp Thr 
     850                855                860
Val Ala Ile Tyr Leu Thr Pro Glu Ser Arg Ser Ser Phe Lys Gln Ala 
 865                870                875                880
Leu Glu Ala Leu Pro Gln Leu Ala Ser Gly Ala Asp Lys Lys Leu Leu 
                 885                890                895
Glu Glu Leu Leu Asn Lys Phe Lys Ser Ser Met His Leu Gln Leu Thr 
             900                905                910
Cys Phe Gln Ala Ala Ser Pro Thr Val Met Lys Thr 
         915                920



<210> 676
<211> 2001
<212> DNA
<213> Homo sapiens
<308> AJ420556
<400> 676

ggcacgagg  gaacctgga  tttatgcag  atattttga  tggaaggac  gcctgcctc  60
aacaggtgt  agaaactat  taaaagaag  actggtgaa  ataattgcc  tgcatgcag  120
ggtgttcac  atttccaaa  aactggtcc  tcgggtact  tccaaggtg  tagaagcag  180
ttctgaaga  ctcagtcga  tgatgcagt  tgtttcatc  ttcagcaaa  atggagctt  240
acaggcgag  cttgaaatc  gtgctttga  ggacactgt  gctgtttac  tgacacccg  300
aagcaagtc  agttttaag  aggctttgg  agccctgcc  cagctttcc  gtggagcag  360
taaaaagtt  ctggaagag  tcctgaaca  gttcaagag  agcatgcac  tgcagctca  420
ctgtttcca  gcagcttct  caaccatga  gaaaacata  atatctgcc  cataaaaga  480
gtccaggaa  ataacacgt  ataagactg  tcactctct  agtacccta  aggtatttg  540
tgtattaaa  attgggttt  ccatttttc  cttttttct  cctctgact  cgaaaattg  600
tggtataca  ttcaaccaa  atgacctca  ttgaaatgc  caggaagta  ttgttttgc  660
attcttact  gatcagatc  tgtatgact  taaaataca  tttaaaata  attttgcat  720
tcagcagaa  gttgagtgc  gcaggaaga  ctgcttctg  agggagttt  ctggaatgg  780
gtggcacat  ttgaagcat  tctcagtgt  ccgttcacg  aagcgcagg  agctcccac  840
acacacgga  agactgact  atacgagat  tggaaagct  tgtagacat  tttggagct  900
ttactgtcc  aaactgtac  gctgtgctt  aaaccctta  ttcatataa  tggccttaa  960
ttttctaat  caagcgggt  tttggaaaa  tttatggtc  ccattaaaa  acatattac  1020
actggggta  attatttgt  gtccaggtg  ctgtgattt  actttgcgt  ttgctatct  1080
atttttatt  ttcacaggg  taagcatga  ctttcattc  cactcactc  taatttgtc  1140
tgcgtcact  cacatgcac  tgttgcagt  cctgaggcc  tgtgtgtta  ctgtgatgg  1200
gtgtgaatg  gtaacgggc  ctgtgttac  ctctcaggt  ttggcgggg  ggtcgcaga  1260
ttcagggtc  cctaacgga  aggccaggc  ccgcgtgga  ggccaactc  ctgcccgct  1320
cttcagcag  tgactgtct  tgccacttc  tacctgctg  aggatcttg  tcagtagct  1380
gaacaatgc  gctgtcaca  agtctcttc  ctgaaactt  aggatgctc  ttggtcacc  1440
ggcaatggg  gctgtagac  agccgcatg  acttgcccc  cattcactg  tgactggct  1500
cactggaat  ggttcaggt  accgggact  ctctcagag  cagcagccc  cccaactcc  1560
tcataccgt  gcatctgaa  attttcaga  aggaattct  tttggtagt  ggcttgtca  1620
ggttttcaa  tttttctat  gttattttt  aatctcttt  tttaaatgc  aaaattaat  1680
tcctcatta  tgcaagtaa  tttagagca  agtgtagcc  tgtacagtt  ccattattt  1740
aaataaata  atgtgttgg  tcatttggt  tatgggggg  catcatggt  actggaaat  1800
aaagtttaa  ctttcacaa  tgtgcttga  aaagctgtt  agaattgtc  ttcctaagt  1860
tgttaactg  tgtatctaa  tcaactgtg  gctaagttt  aaaactgca  tcatgaatg  1920
ttgtgatat  ttaaatatc  actacagca  attcagcca  taaagaatc  gcctttaaa  1980
aaaaaaaaa  aaaaaacat  c  2001



<210> 677
<211> 924
<212> PRT
<213> Homo sapiens
<308> CAB54145
<400> 677

Met Ser Arg Ser Arg Gln Pro Pro Leu Val Thr Gly Ile Ser Pro Asn 
  1               5                  10                  15
Glu Gly Ile Pro Trp Thr Lys Val Thr Ile Arg Gly Glu Asn Leu Gly 
             20                  25                  30
Thr Gly Pro Thr Asp Leu Ile Gly Leu Thr Ile Cys Gly His Asn Cys 
         35                  40                  45
Leu Leu Thr Ala Glu Trp Met Ser Ala Ser Lys Ile Val Cys Arg Val 
     50                  55                  60
Gly Gln Ala Lys Asn Asp Lys Gly Asp Ile Ile Val Thr Thr Lys Ser 
 65                  70                  75                  80
Gly Gly Arg Gly Thr Ser Thr Val Ser Phe Lys Leu Leu Lys Pro Glu 
                 85                  90                  95
Lys Ile Gly Ile Leu Asp Gln Ser Ala Val Trp Val Asp Glu Met Asn 
             100                105                110
Tyr Tyr Asp Met Arg Thr Asp Arg Asn Lys Gly Ile Pro Pro Leu Ser 
         115                120                125
Leu Arg Pro Ala Asn Pro Leu Gly Ile Glu Ile Glu Lys Ser Lys Phe 
     130                135                140
Ser Gln Lys Asp Leu Glu Met Leu Phe His Gly Met Ser Ala Asp Phe 
 145                150                155                160
Thr Ser Glu Asn Phe Ser Ala Ala Trp Tyr Leu Ile Glu Asn His Ser 
                 165                170                175
Asn Thr Ser Phe Glu Gln Leu Lys Met Ala Val Thr Asn Leu Lys Arg 
             180                185                190
Gln Ala Asn Lys Lys Ser Glu Gly Ser Leu Ala Tyr Val Lys Gly Gly 
         195                200                205
Leu Ser Thr Phe Phe Glu Ala Gln Asp Ala Leu Ser Ala Ile His Gln 
     210                215                220
Lys Leu Glu Ala Asp Gly Thr Glu Lys Val Glu Gly Ser Met Thr Gln 
 225                230                235                240
Lys Leu Glu Asn Val Leu Asn Arg Ala Ser Asn Thr Ala Asp Thr Leu 
                 245                250                255
Phe Gln Glu Val Leu Gly Arg Lys Asp Lys Ala Asp Ser Thr Arg Asn 
             260                265                270
Ala Leu Asn Val Leu Gln Arg Phe Lys Phe Leu Phe Asn Leu Pro Leu 
         275                280                285
Asn Ile Glu Arg Asn Ile Gln Lys Gly Asp Tyr Asp Val Val Ile Asn 
     290                295                300
Asp Tyr Glu Lys Ala Lys Ser Leu Phe Gly Lys Thr Glu Val Gln Val 
 305                310                315                320
Phe Lys Lys Tyr Tyr Ala Glu Val Glu Thr Arg Ile Glu Ala Leu Arg 
                 325                330                335
Glu Leu Leu Leu Asp Lys Leu Leu Glu Thr Pro Ser Thr Leu His Asp 
             340                345                350
Gln Lys Arg Tyr Ile Arg Tyr Leu Ser Asp Leu His Ala Ser Gly Asp 
         355                360                365
Pro Ala Trp Gln Cys Ile Gly Ala Gln His Lys Trp Ile Leu Gln Leu 
     370                375                380
Met His Ser Cys Lys Glu Gly Tyr Val Lys Asp Leu Lys Gly Asn Pro 
 385                390                395                400
Gly Leu His Ser Pro Met Leu Asp Leu Asp Asn Asp Thr Arg Pro Ser 
                 405                410                415
Val Leu Gly His Leu Ser Gln Thr Ala Ser Leu Lys Arg Gly Ser Ser 
             420                425                430
Phe Gln Ser Gly Arg Asp Asp Thr Trp Arg Tyr Lys Thr Pro His Arg 
         435                440                445
Val Ala Phe Val Glu Lys Leu Thr Lys Leu Val Leu Ser Gln Leu Pro 
     450                455                460
Asn Phe Trp Lys Leu Trp Ile Ser Tyr Val Asn Gly Ser Leu Phe Ser 
 465                470                475                480
Glu Thr Ala Glu Lys Ser Gly Gln Ile Glu Arg Ser Lys Asn Val Arg 
                 485                490                495
Gln Arg Gln Asn Asp Phe Lys Lys Met Ile Gln Glu Val Met His Ser 
             500                505                510
Leu Val Lys Leu Thr Arg Gly Ala Leu Leu Pro Leu Ser Ile Arg Asp 
         515                520                525
Gly Glu Ala Lys Gln Tyr Gly Gly Trp Glu Val Lys Cys Glu Leu Ser 
     530                535                540
Gly Gln Trp Leu Ala His Ala Ile Gln Thr Val Arg Leu Thr His Glu 
 545                550                555                560
Ser Leu Thr Ala Leu Glu Ile Pro Asn Asp Leu Leu Gln Thr Ile Gln 
                 565                570                575
Asp Leu Ile Leu Asp Leu Arg Val Arg Cys Val Met Ala Thr Leu Gln 
             580                585                590
His Thr Ala Glu Glu Ile Lys Arg Leu Ala Glu Lys Glu Asp Trp Ile 
         595                600                605
Val Asp Asn Glu Gly Leu Thr Ser Leu Pro Cys Gln Phe Glu Gln Cys 
     610                615                620
Ile Val Cys Ser Leu Gln Ser Leu Lys Gly Val Leu Glu Cys Lys Pro 
 625                630                635                640
Gly Glu Ala Ser Val Phe Gln Gln Pro Lys Thr Gln Glu Glu Val Cys 
                 645                650                655
Gln Leu Ser Ile Asn Ile Met Gln Val Phe Ile Tyr Cys Leu Glu Gln 
             660                665                670
Leu Ser Thr Lys Pro Asp Ala Asp Ile Asp Thr Thr His Leu Ser Val 
         675                680                685
Asp Val Ser Ser Pro Asp Leu Phe Gly Ser Ile His Glu Asp Phe Ser 
     690                695                700
Leu Thr Ser Glu Gln Arg Leu Leu Ile Val Leu Ser Asn Cys Cys Tyr 
 705                710                715                720
Leu Glu Arg His Thr Phe Leu Asn Ile Ala Glu His Phe Glu Lys His 
                 725                730                735
Asn Phe Gln Gly Ile Glu Lys Ile Thr Gln Val Ser Met Ala Ser Leu 
             740                745                750
Lys Glu Leu Asp Gln Arg Leu Phe Glu Asn Tyr Ile Glu Leu Lys Ala 
         755                760                765
Asp Pro Ile Val Gly Ser Leu Glu Pro Gly Ile Tyr Ala Gly Tyr Phe 
     770                775                780
Asp Trp Lys Asp Cys Leu Pro Pro Thr Gly Val Arg Asn Tyr Leu Lys 
 785                790                795                800
Glu Ala Leu Val Asn Ile Ile Ala Val His Ala Glu Val Phe Thr Ile 
                 805                810                815
Ser Lys Glu Leu Val Pro Arg Val Leu Ser Lys Val Ile Glu Ala Val 
             820                825                830
Ser Glu Glu Leu Ser Arg Leu Met Gln Cys Val Ser Ser Phe Ser Lys 
         835                840                845
Asn Gly Ala Leu Gln Ala Arg Leu Glu Ile Cys Ala Leu Arg Asp Thr 
     850                855                860
Val Ala Val Tyr Leu Thr Pro Glu Ser Lys Ser Ser Phe Lys Gln Ala 
 865                870                875                880
Leu Glu Ala Leu Pro Gln Leu Ser Ser Gly Ala Asp Lys Lys Leu Leu 
                 885                890                895
Glu Glu Leu Leu Asn Lys Phe Lys Ser Ser Met His Leu Gln Leu Thr 
             900                905                910
Cys Phe Gln Ala Ala Ser Ser Thr Met Met Lys Thr 
         915                920



<210> 678
<211> 4358
<212> DNA
<213> Rattus norvegicus
<308> AF032666
<400> 678

actgctgcg  cccggagcg  gttggcccg  acctgacgc  gcctgcaag  tgcaggaca  60
agggctgga  atggcagat  ccaggagct  gcagccagc  cagccgaat  gtgtctcca  120
ctggagtgc  ggagagaga  actgaaaac  aaaaaggtt  cttttataa  tggaacagg  180
gtttgctgc  caaagtaca  tgtctcgat  ccggcagcc  ccacttgtg  caggcatct  240
tccaaatga  gggattcct  ggaccaaag  cacaattag  ggggagaat  tgggtactg  300
tcccactga  cttataggc  tgacaattt  tggacataa  tgcctcctc  cggcagaat  360
gatgtctgc  agtaaaatt  tctgtcgag  gggacaagc  aaaaatgac  aaggagaca  420
tattgtcac  accaagtca  ggggcagag  aacctcaac  gtctctttt  agctactca  480
acctgaaaa  ataggcatt  tggatcagt  tgcagtgtg  gtggatgag  tgaattatt  540
tgatatgcg  actgacagg  ataagggga  tcccccctt  tcacttcgt  ctgcgaatc  600
tctcggcat  gaaattgag  agtgtaaac  tcctcagaa  aacttagaa  tgttattcc  660
tggcatgag  gctgatttt  cgagtgaga  tttttcagc  gcctggtat  tcatagaga  720
ccactccaa  accagtttt  agcagctca  gatggcagt  accaacctc  aaaggcagg  780
caacaagaa  agcgagggt  gtctagcgt  cgtgaaggg  ggcctcagt  ccttctttg  840
agctcaaga  gctctctca  ctatccatc  aaaactaga  gcagacgga  cagaaaaag  900
agaaggatc  atgacacag  aattggaga  tgtcctcaa  agagcaagt  atactgctg  960
cacattgtt  caagaagtg  taggtcgga  agacaaggc  gattccact  ggaatgcac  1020
caacgtgct  cagcggttt  aatttctct  caaccttcc  ctcaatatc  aacggaaca  1080
tcaaaaggg  gattatgat  tggttatta  tgattatga  aaagccaaa  cgctctttg  1140
gaaaacgga  gtgcaagtt  tcaagaaat  ttatgctga  gtagaggca  gaattgaag  1200
tctaagaga  ttacttcta  agaaactgc  cgagactcc  tcaacctta  atgaccaga  1260
gcgttacat  aggtatctt  ctgacctcc  tgctcctgg  gatcctgct  ggcagtgta  1320
cggagctca  cacaagtgg  ccctcaaac  catgcaaga  tgcaaagaa  gccacatga  1380
gagcctgaa  ggtaaccca  gcccacaca  ccccatgct  gacctagat  atgatgccc  1440
cccctctgt  ttgggccat  tcagtcaga  agcatcact  aagagaggc  gcagcttcc  1500
gtctggtcg  gatgacaca  ggaggtaca  gacgcccca  agagtggca  ttgttgaaa  1560
attaacgaa  cttgtgtta  gtcagctgc  taacttctg  aaactctgg  tttcatatg  1620
taatggaag  ctgttcagt  agacagctg  gaagtcagg  cagattgaa  gatcaaaga  1680
tgtgaggca  agacaaaat  atttcaaga  aatgattca  gaagtaatg  actccctgg  1740
gaagttgat  cggggagcc  tgctcccat  cagcctccg  gaaggggat  ggagacagt  1800
tggcggctg  gaggtgcag  cagagctct  ggggcagtg  ctcgcacac  ttatccaga  1860
cataaggct  acatatgaa  cactgaccg  tctggagat  cccaatgac  tgttacaga  1920
tatccagga  ctgattttg  atctccgta  acattgcat  atggtgacg  tgcaacata  1980
agctgaaga  ataaagaga  tagctgaaa  agaagattg  attgttgat  acgaaggac  2040
gacttccct  ccatgtcag  ttgaacaga  cattgttca  tccctgcag  cgttgaagg  2100
tgttgtgga  tgcaaacct  gagaagcca  tgtctttca  cagcctaaa  cccaggagg  2160
ggtttgcca  ttgtgcatc  gtatcatgc  ggtttttat  tactgcctg  aacaactga  2220
caccaagcc  gatgcggac  tagatacta  tcatctttc  gttgatgtt  cttctcctg  2280
tttgtttgg  agcatccat  aagacttcg  tttgacttc  gagcagagg  ttttgatag  2340
cctgagtaa  tgctgctat  tagaacgtc  caccttcct  aacatagca  aacattttg  2400
aaagcacaa  ttccaggga  tagaaaaaa  aacacaggt  agtatggca  cactgaaag  2460
actggatca  cgactcttt  aaaattaca  tgagctaaa  gcagatcct  ttgttggat  2520
cttggaaac  gggatatat  caggctatt  tgattggaa  gactgtctg  ctccagcag  2580
tgtcagaaa  tatttaaaa  aagcactgg  gaatataat  gctgtgcat  cagaggtgt  2640
cactatttc  aaagaactg  tgccccggg  cctggccag  gtgatagaa  cagtctctg  2700
agagctgag  cggctgatg  agtgtgtct  atccttcag  agaaatgga  cgctgcagg  2760
cagacttga  atctgtgct  tgagggaca  tgtagccat  tacctgacc  cggagagca  2820
gtctagttt  aaacaggcc  tggaggccc  gcctcagct  gcaagtggt  cagacaaaa  2880
gctactgga  gagctgctc  acaagttca  gagcagtat  cacttgcag  tcacctgct  2940
ccaagctgc  tctccaaca  tgatgaaga  atagacaca  acagagatc  cagtccaag  3000
actgcattt  ccttctctc  tttccccag  atggtggtg  agaaagatg  tgatgggta  3060
ttaatttca  ccgatttag  ctaccatac  attttgtta  tactagctt  ggtcctgta  3120
catactctt  aaaatgttt  ttcttagct  tatgtttct  ggtgtgagt  ttgagagct  3180
ctccagcat  gcccaaagc  gccnatggt  tgtgtgaat  tgctncgca  tggcgctct  3240
cctggcctc  gtgttggca  tttccagcc  aggggagga  atgaagtca  agcttttgg  3300
gctgtcata  actttaaac  caccatttc  aacaagtgg  tctaggtgc  ctctctctc  3360
ctctctctc  ctctctctc  ctctctctg  aaagaaaaa  ataaaaatg  taaaatctg  3420
gatgcagaa  tccctggat  aactctgaa  ttcatagtc  ggctttcat  tttcccagt  3480
ttcaacacg  aagcttctg  ttctcaccc  taagttgat  catcgttgt  gggagggtt  3540
acaaggacc  gaatgtgga  gccctgtca  acccgcaag  cctgtggca  gcttgtggt  3600
ttcaatgca  cctaaagat  aagccaggc  cctcccctc  cgcaggtta  tcccctctg  3660
tactttcca  acttcgaaa  gtcttgctc  atagctgga  agatggtgc  ctggcacag  3720
ctgtgtttt  taaagatta  aggtgcctc  gtgaccagg  attgagcag  gactcactg  3780
tcactggct  gcacagtag  atctggtca  tgcgacctg  aagcagctt  tacctcact  3840
catctgacc  tagcttcag  tctggttca  tccagacag  tctgtggcg  ctttctttc  3900
gttgacaaa  ttcctgtca  ttttagttc  ggtaattcc  gagcacagc  tatgcacac  3960
atggattat  tgaggttaa  aacagtgtg  ttatttatc  cagtaactg  aagtacaaa  4020
ttaatcctt  gtttgcaaa  tatgtatgt  cagcattgt  tcctcagtg  actggtatt  4080
catctggca  agccaaact  aattccaag  cagaagtac  caactattg  ttgtttaaa  4140
acctaacaa  tacactaca  aaagccagt  gtcttcctt  tctgtaaaa  ctctaagtg  4200
ctttatttc  ccatttttt  ttagctctg  aattgttta  attcctagt  ttaaaatcc  4260
aaataaata  tggtgttct  tctttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  4320
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4358



<210> 679
<211> 924
<212> PRT
<213> Rattus norvegicus
<308> AAC01578
<400> 679

Met Ser Arg Ser Arg Gln Pro Pro Leu Val Thr Gly Ile Ser Pro Asn 
  1               5                  10                  15
Glu Gly Ile Pro Trp Thr Lys Val Thr Ile Arg Gly Glu Asn Leu Gly 
             20                  25                  30
Thr Gly Pro Thr Asp Leu Ile Gly Leu Thr Ile Cys Gly His Asn Cys 
         35                  40                  45
Leu Leu Thr Ala Glu Trp Met Ser Ala Ser Lys Ile Val Cys Arg Val 
     50                  55                  60
Gly Gln Ala Lys Asn Asp Lys Gly Asp Ile Ile Val Thr Thr Lys Ser 
 65                  70                  75                  80
Gly Gly Arg Gly Thr Ser Thr Val Ser Phe Lys Leu Leu Lys Pro Glu 
                 85                  90                  95
Lys Ile Gly Ile Leu Asp Gln Ser Ala Val Trp Val Asp Glu Met Asn 
             100                105                110
Tyr Tyr Asp Met Arg Thr Asp Arg Asn Lys Gly Ile Pro Pro Leu Ser 
         115                120                125
Leu Arg Pro Ala Asn Pro Leu Gly Ile Glu Ile Glu Lys Cys Lys Leu 
     130                135                140
Pro Gln Lys Asn Leu Glu Val Leu Phe His Gly Met Ser Ala Asp Phe 
 145                150                155                160
Thr Ser Glu Asn Phe Ser Ala Ala Trp Tyr Leu Ile Glu Asn His Ser 
                 165                170                175
Asn Thr Ser Phe Glu Gln Leu Lys Met Ala Val Thr Asn Leu Lys Arg 
             180                185                190
Gln Ala Asn Lys Lys Ser Glu Gly Ser Leu Ala Tyr Val Lys Gly Gly 
         195                200                205
Leu Ser Thr Phe Phe Glu Ala Gln Asp Ala Leu Ser Ala Ile His Gln 
     210                215                220
Lys Leu Glu Ala Asp Gly Thr Glu Lys Val Glu Gly Ser Met Thr Gln 
 225                230                235                240
Lys Leu Glu Asn Val Leu Asn Arg Ala Ser Asn Thr Ala Asp Thr Leu 
                 245                250                255
Phe Gln Glu Val Leu Gly Arg Lys Asp Lys Ala Asp Ser Thr Arg Asn 
             260                265                270
Ala Leu Asn Val Leu Gln Arg Phe Lys Phe Leu Phe Asn Leu Pro Leu 
         275                280                285
Asn Ile Lys Arg Asn Ile Gln Lys Gly Asp Tyr Asp Val Val Ile Asn 
     290                295                300
Asp Tyr Glu Lys Ala Lys Ser Leu Phe Gly Lys Thr Glu Val Gln Val 
 305                310                315                320
Phe Lys Lys Tyr Tyr Ala Glu Val Glu Ala Gly Ile Glu Asp Leu Arg 
                 325                330                335
Glu Leu Leu Leu Lys Lys Leu Leu Glu Thr Pro Ser Thr Leu His Asp 
             340                345                350
Gln Lys Arg Tyr Ile Arg Tyr Leu Ser Asp Leu His Ala Pro Gly Asp 
         355                360                365
Pro Ala Trp Gln Cys Ile Gly Ala Gln His Lys Trp Thr Leu Lys Leu 
     370                375                380
Met Gln Asp Cys Lys Glu Gly His Met Lys Ser Leu Lys Gly Asn Pro 
 385                390                395                400
Gly Pro His Ser Pro Met Leu Asp Leu Asp Asn Asp Ala Arg Pro Ser 
                 405                410                415
Val Leu Gly His Leu Ser Gln Thr Ala Ser Leu Lys Arg Gly Ser Ser 
             420                425                430
Phe Gln Ser Gly Arg Asp Asp Thr Trp Arg Tyr Lys Thr Pro His Arg 
         435                440                445
Val Ala Phe Val Glu Lys Leu Thr Lys Leu Val Leu Ser Gln Leu Pro 
     450                455                460
Asn Phe Trp Lys Leu Trp Ile Ser Tyr Val Asn Gly Ser Leu Phe Ser 
 465                470                475                480
Glu Thr Ala Glu Lys Ser Gly Gln Ile Glu Arg Ser Lys Asn Val Arg 
                 485                490                495
Gln Arg Gln Asn Asp Phe Lys Lys Met Ile Gln Glu Val Met His Ser 
             500                505                510
Leu Val Lys Leu Ile Arg Gly Ala Leu Leu Pro Phe Ser Leu Arg Glu 
         515                520                525
Gly Asp Gly Arg Gln Tyr Gly Gly Trp Glu Val Gln Ala Glu Leu Ser 
     530                535                540
Gly Gln Trp Leu Ala His Val Ile Gln Thr Ile Arg Leu Thr Tyr Glu 
 545                550                555                560
Ser Leu Thr Ala Leu Glu Ile Pro Asn Asp Met Leu Gln Ile Ile Gln 
                 565                570                575
Asp Leu Ile Leu Asp Leu Arg Ile His Cys Ile Met Val Thr Leu Gln 
             580                585                590
His Thr Ala Glu Glu Ile Lys Arg Leu Ala Glu Lys Glu Asp Trp Ile 
         595                600                605
Val Asp Asn Glu Gly Leu Thr Ser Leu Pro Cys Gln Phe Glu Gln Ser 
     610                615                620
Ile Val His Ser Leu Gln Ser Leu Lys Gly Val Val Asp Cys Lys Pro 
 625                630                635                640
Gly Glu Ala Ser Val Phe Gln Gln Pro Lys Thr Gln Glu Glu Val Cys 
                 645                650                655
Gln Leu Cys Ile Ser Ile Met Gln Val Phe Ile Tyr Cys Leu Glu Gln 
             660                665                670
Leu Ser Thr Lys Pro Asp Ala Asp Ile Asp Thr Thr His Leu Ser Val 
         675                680                685
Asp Val Ser Ser Pro Asp Leu Phe Gly Ser Ile His Glu Asp Phe Gly 
     690                695                700
Leu Thr Ser Glu Gln Arg Leu Leu Ile Val Leu Ser Asn Cys Cys Tyr 
 705                710                715                720
Leu Glu Arg His Thr Phe Leu Asn Ile Ala Glu His Phe Glu Lys His 
                 725                730                735
Asn Phe Gln Gly Ile Glu Lys Ile Thr Gln Val Ser Met Ala Ser Leu 
             740                745                750
Lys Glu Leu Asp Gln Arg Leu Phe Glu Asn Tyr Ile Glu Leu Lys Ala 
         755                760                765
Asp Pro Ile Val Gly Ser Leu Glu Thr Gly Ile Tyr Ala Gly Tyr Phe 
     770                775                780
Asp Trp Lys Asp Cys Leu Pro Pro Ala Gly Val Arg Asn Tyr Leu Lys 
 785                790                795                800
Glu Ala Leu Val Asn Ile Ile Ala Val His Ala Glu Val Phe Thr Ile 
                 805                810                815
Ser Lys Glu Leu Val Pro Arg Val Leu Ala Arg Val Ile Glu Ala Val 
             820                825                830
Ser Glu Glu Leu Ser Arg Leu Met Gln Cys Val Ser Ser Phe Ser Arg 
         835                840                845
Asn Gly Ala Leu Gln Ala Arg Leu Glu Ile Cys Ala Leu Arg Asp Thr 
     850                855                860
Val Ala Ile Tyr Leu Thr Pro Glu Ser Arg Ser Ser Phe Lys Gln Ala 
 865                870                875                880
Leu Glu Ala Leu Pro Gln Leu Ala Ser Gly Ala Asp Lys Lys Leu Leu 
                 885                890                895
Glu Glu Leu Leu Asn Lys Phe Lys Ser Ser Met His Leu Gln Leu Thr 
             900                905                910
Cys Phe Gln Ala Ala Ser Pro Thr Val Met Lys Thr 
         915                920



<210> 680
<211> 2001
<212> DNA
<213> Homo sapiens
<308> AJ420556
<400> 680

ggcacgagg  gaacctgga  tttatgcag  atattttga  tggaaggac  gcctgcctc  60
aacaggtgt  agaaactat  taaaagaag  actggtgaa  ataattgcc  tgcatgcag  120
ggtgttcac  atttccaaa  aactggtcc  tcgggtact  tccaaggtg  tagaagcag  180
ttctgaaga  ctcagtcga  tgatgcagt  tgtttcatc  ttcagcaaa  atggagctt  240
acaggcgag  cttgaaatc  gtgctttga  ggacactgt  gctgtttac  tgacacccg  300
aagcaagtc  agttttaag  aggctttgg  agccctgcc  cagctttcc  gtggagcag  360
taaaaagtt  ctggaagag  tcctgaaca  gttcaagag  agcatgcac  tgcagctca  420
ctgtttcca  gcagcttct  caaccatga  gaaaacata  atatctgcc  cataaaaga  480
gtccaggaa  ataacacgt  ataagactg  tcactctct  agtacccta  aggtatttg  540
tgtattaaa  attgggttt  ccatttttc  cttttttct  cctctgact  cgaaaattg  600
tggtataca  ttcaaccaa  atgacctca  ttgaaatgc  caggaagta  ttgttttgc  660
attcttact  gatcagatc  tgtatgact  taaaataca  tttaaaata  attttgcat  720
tcagcagaa  gttgagtgc  gcaggaaga  ctgcttctg  agggagttt  ctggaatgg  780
gtggcacat  ttgaagcat  tctcagtgt  ccgttcacg  aagcgcagg  agctcccac  840
acacacgga  agactgact  atacgagat  tggaaagct  tgtagacat  tttggagct  900
ttactgtcc  aaactgtac  gctgtgctt  aaaccctta  ttcatataa  tggccttaa  960
ttttctaat  caagcgggt  tttggaaaa  tttatggtc  ccattaaaa  acatattac  1020
actggggta  attatttgt  gtccaggtg  ctgtgattt  actttgcgt  ttgctatct  1080
atttttatt  ttcacaggg  taagcatga  ctttcattc  cactcactc  taatttgtc  1140
tgcgtcact  cacatgcac  tgttgcagt  cctgaggcc  tgtgtgtta  ctgtgatgg  1200
gtgtgaatg  gtaacgggc  ctgtgttac  ctctcaggt  ttggcgggg  ggtcgcaga  1260
ttcagggtc  cctaacgga  aggccaggc  ccgcgtgga  ggccaactc  ctgcccgct  1320
cttcagcag  tgactgtct  tgccacttc  tacctgctg  aggatcttg  tcagtagct  1380
gaacaatgc  gctgtcaca  agtctcttc  ctgaaactt  aggatgctc  ttggtcacc  1440
ggcaatggg  gctgtagac  agccgcatg  acttgcccc  cattcactg  tgactggct  1500
cactggaat  ggttcaggt  accgggact  ctctcagag  cagcagccc  cccaactcc  1560
tcataccgt  gcatctgaa  attttcaga  aggaattct  tttggtagt  ggcttgtca  1620
ggttttcaa  tttttctat  gttattttt  aatctcttt  tttaaatgc  aaaattaat  1680
tcctcatta  tgcaagtaa  tttagagca  agtgtagcc  tgtacagtt  ccattattt  1740
aaataaata  atgtgttgg  tcatttggt  tatgggggg  catcatggt  actggaaat  1800
aaagtttaa  ctttcacaa  tgtgcttga  aaagctgtt  agaattgtc  ttcctaagt  1860
tgttaactg  tgtatctaa  tcaactgtg  gctaagttt  aaaactgca  tcatgaatg  1920
ttgtgatat  ttaaatatc  actacagca  attcagcca  taaagaatc  gcctttaaa  1980
aaaaaaaaa  aaaaaacat  c  2001



<210> 681
<211> 924
<212> PRT
<213> Homo sapiens
<308> CAB54145
<400> 681

Met Ser Arg Ser Arg Gln Pro Pro Leu Val Thr Gly Ile Ser Pro Asn 
  1               5                  10                  15
Glu Gly Ile Pro Trp Thr Lys Val Thr Ile Arg Gly Glu Asn Leu Gly 
             20                  25                  30
Thr Gly Pro Thr Asp Leu Ile Gly Leu Thr Ile Cys Gly His Asn Cys 
         35                  40                  45
Leu Leu Thr Ala Glu Trp Met Ser Ala Ser Lys Ile Val Cys Arg Val 
     50                  55                  60
Gly Gln Ala Lys Asn Asp Lys Gly Asp Ile Ile Val Thr Thr Lys Ser 
 65                  70                  75                  80
Gly Gly Arg Gly Thr Ser Thr Val Ser Phe Lys Leu Leu Lys Pro Glu 
                 85                  90                  95
Lys Ile Gly Ile Leu Asp Gln Ser Ala Val Trp Val Asp Glu Met Asn 
             100                105                110
Tyr Tyr Asp Met Arg Thr Asp Arg Asn Lys Gly Ile Pro Pro Leu Ser 
         115                120                125
Leu Arg Pro Ala Asn Pro Leu Gly Ile Glu Ile Glu Lys Ser Lys Phe 
     130                135                140
Ser Gln Lys Asp Leu Glu Met Leu Phe His Gly Met Ser Ala Asp Phe 
 145                150                155                160
Thr Ser Glu Asn Phe Ser Ala Ala Trp Tyr Leu Ile Glu Asn His Ser 
                 165                170                175
Asn Thr Ser Phe Glu Gln Leu Lys Met Ala Val Thr Asn Leu Lys Arg 
             180                185                190
Gln Ala Asn Lys Lys Ser Glu Gly Ser Leu Ala Tyr Val Lys Gly Gly 
         195                200                205
Leu Ser Thr Phe Phe Glu Ala Gln Asp Ala Leu Ser Ala Ile His Gln 
     210                215                220
Lys Leu Glu Ala Asp Gly Thr Glu Lys Val Glu Gly Ser Met Thr Gln 
 225                230                235                240
Lys Leu Glu Asn Val Leu Asn Arg Ala Ser Asn Thr Ala Asp Thr Leu 
                 245                250                255
Phe Gln Glu Val Leu Gly Arg Lys Asp Lys Ala Asp Ser Thr Arg Asn 
             260                265                270
Ala Leu Asn Val Leu Gln Arg Phe Lys Phe Leu Phe Asn Leu Pro Leu 
         275                280                285
Asn Ile Glu Arg Asn Ile Gln Lys Gly Asp Tyr Asp Val Val Ile Asn 
     290                295                300
Asp Tyr Glu Lys Ala Lys Ser Leu Phe Gly Lys Thr Glu Val Gln Val 
 305                310                315                320
Phe Lys Lys Tyr Tyr Ala Glu Val Glu Thr Arg Ile Glu Ala Leu Arg 
                 325                330                335
Glu Leu Leu Leu Asp Lys Leu Leu Glu Thr Pro Ser Thr Leu His Asp 
             340                345                350
Gln Lys Arg Tyr Ile Arg Tyr Leu Ser Asp Leu His Ala Ser Gly Asp 
         355                360                365
Pro Ala Trp Gln Cys Ile Gly Ala Gln His Lys Trp Ile Leu Gln Leu 
     370                375                380
Met His Ser Cys Lys Glu Gly Tyr Val Lys Asp Leu Lys Gly Asn Pro 
 385                390                395                400
Gly Leu His Ser Pro Met Leu Asp Leu Asp Asn Asp Thr Arg Pro Ser 
                 405                410                415
Val Leu Gly His Leu Ser Gln Thr Ala Ser Leu Lys Arg Gly Ser Ser 
             420                425                430
Phe Gln Ser Gly Arg Asp Asp Thr Trp Arg Tyr Lys Thr Pro His Arg 
         435                440                445
Val Ala Phe Val Glu Lys Leu Thr Lys Leu Val Leu Ser Gln Leu Pro 
     450                455                460
Asn Phe Trp Lys Leu Trp Ile Ser Tyr Val Asn Gly Ser Leu Phe Ser 
 465                470                475                480
Glu Thr Ala Glu Lys Ser Gly Gln Ile Glu Arg Ser Lys Asn Val Arg 
                 485                490                495
Gln Arg Gln Asn Asp Phe Lys Lys Met Ile Gln Glu Val Met His Ser 
             500                505                510
Leu Val Lys Leu Thr Arg Gly Ala Leu Leu Pro Leu Ser Ile Arg Asp 
         515                520                525
Gly Glu Ala Lys Gln Tyr Gly Gly Trp Glu Val Lys Cys Glu Leu Ser 
     530                535                540
Gly Gln Trp Leu Ala His Ala Ile Gln Thr Val Arg Leu Thr His Glu 
 545                550                555                560
Ser Leu Thr Ala Leu Glu Ile Pro Asn Asp Leu Leu Gln Thr Ile Gln 
                 565                570                575
Asp Leu Ile Leu Asp Leu Arg Val Arg Cys Val Met Ala Thr Leu Gln 
             580                585                590
His Thr Ala Glu Glu Ile Lys Arg Leu Ala Glu Lys Glu Asp Trp Ile 
         595                600                605
Val Asp Asn Glu Gly Leu Thr Ser Leu Pro Cys Gln Phe Glu Gln Cys 
     610                615                620
Ile Val Cys Ser Leu Gln Ser Leu Lys Gly Val Leu Glu Cys Lys Pro 
 625                630                635                640
Gly Glu Ala Ser Val Phe Gln Gln Pro Lys Thr Gln Glu Glu Val Cys 
                 645                650                655
Gln Leu Ser Ile Asn Ile Met Gln Val Phe Ile Tyr Cys Leu Glu Gln 
             660                665                670
Leu Ser Thr Lys Pro Asp Ala Asp Ile Asp Thr Thr His Leu Ser Val 
         675                680                685
Asp Val Ser Ser Pro Asp Leu Phe Gly Ser Ile His Glu Asp Phe Ser 
     690                695                700
Leu Thr Ser Glu Gln Arg Leu Leu Ile Val Leu Ser Asn Cys Cys Tyr 
 705                710                715                720
Leu Glu Arg His Thr Phe Leu Asn Ile Ala Glu His Phe Glu Lys His 
                 725                730                735
Asn Phe Gln Gly Ile Glu Lys Ile Thr Gln Val Ser Met Ala Ser Leu 
             740                745                750
Lys Glu Leu Asp Gln Arg Leu Phe Glu Asn Tyr Ile Glu Leu Lys Ala 
         755                760                765
Asp Pro Ile Val Gly Ser Leu Glu Pro Gly Ile Tyr Ala Gly Tyr Phe 
     770                775                780
Asp Trp Lys Asp Cys Leu Pro Pro Thr Gly Val Arg Asn Tyr Leu Lys 
 785                790                795                800
Glu Ala Leu Val Asn Ile Ile Ala Val His Ala Glu Val Phe Thr Ile 
                 805                810                815
Ser Lys Glu Leu Val Pro Arg Val Leu Ser Lys Val Ile Glu Ala Val 
             820                825                830
Ser Glu Glu Leu Ser Arg Leu Met Gln Cys Val Ser Ser Phe Ser Lys 
         835                840                845
Asn Gly Ala Leu Gln Ala Arg Leu Glu Ile Cys Ala Leu Arg Asp Thr 
     850                855                860
Val Ala Val Tyr Leu Thr Pro Glu Ser Lys Ser Ser Phe Lys Gln Ala 
 865                870                875                880
Leu Glu Ala Leu Pro Gln Leu Ser Ser Gly Ala Asp Lys Lys Leu Leu 
                 885                890                895
Glu Glu Leu Leu Asn Lys Phe Lys Ser Ser Met His Leu Gln Leu Thr 
             900                905                910
Cys Phe Gln Ala Ala Ser Ser Thr Met Met Lys Thr 
         915                920



<210> 682
<211> 4358
<212> DNA
<213> Rattus norvegicus
<308> AF032666
<400> 682

actgctgcg  cccggagcg  gttggcccg  acctgacgc  gcctgcaag  tgcaggaca  60
agggctgga  atggcagat  ccaggagct  gcagccagc  cagccgaat  gtgtctcca  120
ctggagtgc  ggagagaga  actgaaaac  aaaaaggtt  cttttataa  tggaacagg  180
gtttgctgc  caaagtaca  tgtctcgat  ccggcagcc  ccacttgtg  caggcatct  240
tccaaatga  gggattcct  ggaccaaag  cacaattag  ggggagaat  tgggtactg  300
tcccactga  cttataggc  tgacaattt  tggacataa  tgcctcctc  cggcagaat  360
gatgtctgc  agtaaaatt  tctgtcgag  gggacaagc  aaaaatgac  aaggagaca  420
tattgtcac  accaagtca  ggggcagag  aacctcaac  gtctctttt  agctactca  480
acctgaaaa  ataggcatt  tggatcagt  tgcagtgtg  gtggatgag  tgaattatt  540
tgatatgcg  actgacagg  ataagggga  tcccccctt  tcacttcgt  ctgcgaatc  600
tctcggcat  gaaattgag  agtgtaaac  tcctcagaa  aacttagaa  tgttattcc  660
tggcatgag  gctgatttt  cgagtgaga  tttttcagc  gcctggtat  tcatagaga  720
ccactccaa  accagtttt  agcagctca  gatggcagt  accaacctc  aaaggcagg  780
caacaagaa  agcgagggt  gtctagcgt  cgtgaaggg  ggcctcagt  ccttctttg  840
agctcaaga  gctctctca  ctatccatc  aaaactaga  gcagacgga  cagaaaaag  900
agaaggatc  atgacacag  aattggaga  tgtcctcaa  agagcaagt  atactgctg  960
cacattgtt  caagaagtg  taggtcgga  agacaaggc  gattccact  ggaatgcac  1020
caacgtgct  cagcggttt  aatttctct  caaccttcc  ctcaatatc  aacggaaca  1080
tcaaaaggg  gattatgat  tggttatta  tgattatga  aaagccaaa  cgctctttg  1140
gaaaacgga  gtgcaagtt  tcaagaaat  ttatgctga  gtagaggca  gaattgaag  1200
tctaagaga  ttacttcta  agaaactgc  cgagactcc  tcaacctta  atgaccaga  1260
gcgttacat  aggtatctt  ctgacctcc  tgctcctgg  gatcctgct  ggcagtgta  1320
cggagctca  cacaagtgg  ccctcaaac  catgcaaga  tgcaaagaa  gccacatga  1380
gagcctgaa  ggtaaccca  gcccacaca  ccccatgct  gacctagat  atgatgccc  1440
cccctctgt  ttgggccat  tcagtcaga  agcatcact  aagagaggc  gcagcttcc  1500
gtctggtcg  gatgacaca  ggaggtaca  gacgcccca  agagtggca  ttgttgaaa  1560
attaacgaa  cttgtgtta  gtcagctgc  taacttctg  aaactctgg  tttcatatg  1620
taatggaag  ctgttcagt  agacagctg  gaagtcagg  cagattgaa  gatcaaaga  1680
tgtgaggca  agacaaaat  atttcaaga  aatgattca  gaagtaatg  actccctgg  1740
gaagttgat  cggggagcc  tgctcccat  cagcctccg  gaaggggat  ggagacagt  1800
tggcggctg  gaggtgcag  cagagctct  ggggcagtg  ctcgcacac  ttatccaga  1860
cataaggct  acatatgaa  cactgaccg  tctggagat  cccaatgac  tgttacaga  1920
tatccagga  ctgattttg  atctccgta  acattgcat  atggtgacg  tgcaacata  1980
agctgaaga  ataaagaga  tagctgaaa  agaagattg  attgttgat  acgaaggac  2040
gacttccct  ccatgtcag  ttgaacaga  cattgttca  tccctgcag  cgttgaagg  2100
tgttgtgga  tgcaaacct  gagaagcca  tgtctttca  cagcctaaa  cccaggagg  2160
ggtttgcca  ttgtgcatc  gtatcatgc  ggtttttat  tactgcctg  aacaactga  2220
caccaagcc  gatgcggac  tagatacta  tcatctttc  gttgatgtt  cttctcctg  2280
tttgtttgg  agcatccat  aagacttcg  tttgacttc  gagcagagg  ttttgatag  2340
cctgagtaa  tgctgctat  tagaacgtc  caccttcct  aacatagca  aacattttg  2400
aaagcacaa  ttccaggga  tagaaaaaa  aacacaggt  agtatggca  cactgaaag  2460
actggatca  cgactcttt  aaaattaca  tgagctaaa  gcagatcct  ttgttggat  2520
cttggaaac  gggatatat  caggctatt  tgattggaa  gactgtctg  ctccagcag  2580
tgtcagaaa  tatttaaaa  aagcactgg  gaatataat  gctgtgcat  cagaggtgt  2640
cactatttc  aaagaactg  tgccccggg  cctggccag  gtgatagaa  cagtctctg  2700
agagctgag  cggctgatg  agtgtgtct  atccttcag  agaaatgga  cgctgcagg  2760
cagacttga  atctgtgct  tgagggaca  tgtagccat  tacctgacc  cggagagca  2820
gtctagttt  aaacaggcc  tggaggccc  gcctcagct  gcaagtggt  cagacaaaa  2880
gctactgga  gagctgctc  acaagttca  gagcagtat  cacttgcag  tcacctgct  2940
ccaagctgc  tctccaaca  tgatgaaga  atagacaca  acagagatc  cagtccaag  3000
actgcattt  ccttctctc  tttccccag  atggtggtg  agaaagatg  tgatgggta  3060
ttaatttca  ccgatttag  ctaccatac  attttgtta  tactagctt  ggtcctgta  3120
catactctt  aaaatgttt  ttcttagct  tatgtttct  ggtgtgagt  ttgagagct  3180
ctccagcat  gcccaaagc  gccnatggt  tgtgtgaat  tgctncgca  tggcgctct  3240
cctggcctc  gtgttggca  tttccagcc  aggggagga  atgaagtca  agcttttgg  3300
gctgtcata  actttaaac  caccatttc  aacaagtgg  tctaggtgc  ctctctctc  3360
ctctctctc  ctctctctc  ctctctctg  aaagaaaaa  ataaaaatg  taaaatctg  3420
gatgcagaa  tccctggat  aactctgaa  ttcatagtc  ggctttcat  tttcccagt  3480
ttcaacacg  aagcttctg  ttctcaccc  taagttgat  catcgttgt  gggagggtt  3540
acaaggacc  gaatgtgga  gccctgtca  acccgcaag  cctgtggca  gcttgtggt  3600
ttcaatgca  cctaaagat  aagccaggc  cctcccctc  cgcaggtta  tcccctctg  3660
tactttcca  acttcgaaa  gtcttgctc  atagctgga  agatggtgc  ctggcacag  3720
ctgtgtttt  taaagatta  aggtgcctc  gtgaccagg  attgagcag  gactcactg  3780
tcactggct  gcacagtag  atctggtca  tgcgacctg  aagcagctt  tacctcact  3840
catctgacc  tagcttcag  tctggttca  tccagacag  tctgtggcg  ctttctttc  3900
gttgacaaa  ttcctgtca  ttttagttc  ggtaattcc  gagcacagc  tatgcacac  3960
atggattat  tgaggttaa  aacagtgtg  ttatttatc  cagtaactg  aagtacaaa  4020
ttaatcctt  gtttgcaaa  tatgtatgt  cagcattgt  tcctcagtg  actggtatt  4080
catctggca  agccaaact  aattccaag  cagaagtac  caactattg  ttgtttaaa  4140
acctaacaa  tacactaca  aaagccagt  gtcttcctt  tctgtaaaa  ctctaagtg  4200
ctttatttc  ccatttttt  ttagctctg  aattgttta  attcctagt  ttaaaatcc  4260
aaataaata  tggtgttct  tctttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  4320
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4358



<210> 683
<211> 924
<212> PRT
<213> Rattus norvegicus
<308> AAC01578
<400> 683

Met Ser Arg Ser Arg Gln Pro Pro Leu Val Thr Gly Ile Ser Pro Asn 
  1               5                  10                  15
Glu Gly Ile Pro Trp Thr Lys Val Thr Ile Arg Gly Glu Asn Leu Gly 
             20                  25                  30
Thr Gly Pro Thr Asp Leu Ile Gly Leu Thr Ile Cys Gly His Asn Cys 
         35                  40                  45
Leu Leu Thr Ala Glu Trp Met Ser Ala Ser Lys Ile Val Cys Arg Val 
     50                  55                  60
Gly Gln Ala Lys Asn Asp Lys Gly Asp Ile Ile Val Thr Thr Lys Ser 
 65                  70                  75                  80
Gly Gly Arg Gly Thr Ser Thr Val Ser Phe Lys Leu Leu Lys Pro Glu 
                 85                  90                  95
Lys Ile Gly Ile Leu Asp Gln Ser Ala Val Trp Val Asp Glu Met Asn 
             100                105                110
Tyr Tyr Asp Met Arg Thr Asp Arg Asn Lys Gly Ile Pro Pro Leu Ser 
         115                120                125
Leu Arg Pro Ala Asn Pro Leu Gly Ile Glu Ile Glu Lys Cys Lys Leu 
     130                135                140
Pro Gln Lys Asn Leu Glu Val Leu Phe His Gly Met Ser Ala Asp Phe 
 145                150                155                160
Thr Ser Glu Asn Phe Ser Ala Ala Trp Tyr Leu Ile Glu Asn His Ser 
                 165                170                175
Asn Thr Ser Phe Glu Gln Leu Lys Met Ala Val Thr Asn Leu Lys Arg 
             180                185                190
Gln Ala Asn Lys Lys Ser Glu Gly Ser Leu Ala Tyr Val Lys Gly Gly 
         195                200                205
Leu Ser Thr Phe Phe Glu Ala Gln Asp Ala Leu Ser Ala Ile His Gln 
     210                215                220
Lys Leu Glu Ala Asp Gly Thr Glu Lys Val Glu Gly Ser Met Thr Gln 
 225                230                235                240
Lys Leu Glu Asn Val Leu Asn Arg Ala Ser Asn Thr Ala Asp Thr Leu 
                 245                250                255
Phe Gln Glu Val Leu Gly Arg Lys Asp Lys Ala Asp Ser Thr Arg Asn 
             260                265                270
Ala Leu Asn Val Leu Gln Arg Phe Lys Phe Leu Phe Asn Leu Pro Leu 
         275                280                285
Asn Ile Lys Arg Asn Ile Gln Lys Gly Asp Tyr Asp Val Val Ile Asn 
     290                295                300
Asp Tyr Glu Lys Ala Lys Ser Leu Phe Gly Lys Thr Glu Val Gln Val 
 305                310                315                320
Phe Lys Lys Tyr Tyr Ala Glu Val Glu Ala Gly Ile Glu Asp Leu Arg 
                 325                330                335
Glu Leu Leu Leu Lys Lys Leu Leu Glu Thr Pro Ser Thr Leu His Asp 
             340                345                350
Gln Lys Arg Tyr Ile Arg Tyr Leu Ser Asp Leu His Ala Pro Gly Asp 
         355                360                365
Pro Ala Trp Gln Cys Ile Gly Ala Gln His Lys Trp Thr Leu Lys Leu 
     370                375                380
Met Gln Asp Cys Lys Glu Gly His Met Lys Ser Leu Lys Gly Asn Pro 
 385                390                395                400
Gly Pro His Ser Pro Met Leu Asp Leu Asp Asn Asp Ala Arg Pro Ser 
                 405                410                415
Val Leu Gly His Leu Ser Gln Thr Ala Ser Leu Lys Arg Gly Ser Ser 
             420                425                430
Phe Gln Ser Gly Arg Asp Asp Thr Trp Arg Tyr Lys Thr Pro His Arg 
         435                440                445
Val Ala Phe Val Glu Lys Leu Thr Lys Leu Val Leu Ser Gln Leu Pro 
     450                455                460
Asn Phe Trp Lys Leu Trp Ile Ser Tyr Val Asn Gly Ser Leu Phe Ser 
 465                470                475                480
Glu Thr Ala Glu Lys Ser Gly Gln Ile Glu Arg Ser Lys Asn Val Arg 
                 485                490                495
Gln Arg Gln Asn Asp Phe Lys Lys Met Ile Gln Glu Val Met His Ser 
             500                505                510
Leu Val Lys Leu Ile Arg Gly Ala Leu Leu Pro Phe Ser Leu Arg Glu 
         515                520                525
Gly Asp Gly Arg Gln Tyr Gly Gly Trp Glu Val Gln Ala Glu Leu Ser 
     530                535                540
Gly Gln Trp Leu Ala His Val Ile Gln Thr Ile Arg Leu Thr Tyr Glu 
 545                550                555                560
Ser Leu Thr Ala Leu Glu Ile Pro Asn Asp Met Leu Gln Ile Ile Gln 
                 565                570                575
Asp Leu Ile Leu Asp Leu Arg Ile His Cys Ile Met Val Thr Leu Gln 
             580                585                590
His Thr Ala Glu Glu Ile Lys Arg Leu Ala Glu Lys Glu Asp Trp Ile 
         595                600                605
Val Asp Asn Glu Gly Leu Thr Ser Leu Pro Cys Gln Phe Glu Gln Ser 
     610                615                620
Ile Val His Ser Leu Gln Ser Leu Lys Gly Val Val Asp Cys Lys Pro 
 625                630                635                640
Gly Glu Ala Ser Val Phe Gln Gln Pro Lys Thr Gln Glu Glu Val Cys 
                 645                650                655
Gln Leu Cys Ile Ser Ile Met Gln Val Phe Ile Tyr Cys Leu Glu Gln 
             660                665                670
Leu Ser Thr Lys Pro Asp Ala Asp Ile Asp Thr Thr His Leu Ser Val 
         675                680                685
Asp Val Ser Ser Pro Asp Leu Phe Gly Ser Ile His Glu Asp Phe Gly 
     690                695                700
Leu Thr Ser Glu Gln Arg Leu Leu Ile Val Leu Ser Asn Cys Cys Tyr 
 705                710                715                720
Leu Glu Arg His Thr Phe Leu Asn Ile Ala Glu His Phe Glu Lys His 
                 725                730                735
Asn Phe Gln Gly Ile Glu Lys Ile Thr Gln Val Ser Met Ala Ser Leu 
             740                745                750
Lys Glu Leu Asp Gln Arg Leu Phe Glu Asn Tyr Ile Glu Leu Lys Ala 
         755                760                765
Asp Pro Ile Val Gly Ser Leu Glu Thr Gly Ile Tyr Ala Gly Tyr Phe 
     770                775                780
Asp Trp Lys Asp Cys Leu Pro Pro Ala Gly Val Arg Asn Tyr Leu Lys 
 785                790                795                800
Glu Ala Leu Val Asn Ile Ile Ala Val His Ala Glu Val Phe Thr Ile 
                 805                810                815
Ser Lys Glu Leu Val Pro Arg Val Leu Ala Arg Val Ile Glu Ala Val 
             820                825                830
Ser Glu Glu Leu Ser Arg Leu Met Gln Cys Val Ser Ser Phe Ser Arg 
         835                840                845
Asn Gly Ala Leu Gln Ala Arg Leu Glu Ile Cys Ala Leu Arg Asp Thr 
     850                855                860
Val Ala Ile Tyr Leu Thr Pro Glu Ser Arg Ser Ser Phe Lys Gln Ala 
 865                870                875                880
Leu Glu Ala Leu Pro Gln Leu Ala Ser Gly Ala Asp Lys Lys Leu Leu 
                 885                890                895
Glu Glu Leu Leu Asn Lys Phe Lys Ser Ser Met His Leu Gln Leu Thr 
             900                905                910
Cys Phe Gln Ala Ala Ser Pro Thr Val Met Lys Thr 
         915                920



<210> 684
<211> 2001
<212> DNA
<213> Homo sapiens
<308> AJ420556
<400> 684

ggcacgagg  gaacctgga  tttatgcag  atattttga  tggaaggac  gcctgcctc  60
aacaggtgt  agaaactat  taaaagaag  actggtgaa  ataattgcc  tgcatgcag  120
ggtgttcac  atttccaaa  aactggtcc  tcgggtact  tccaaggtg  tagaagcag  180
ttctgaaga  ctcagtcga  tgatgcagt  tgtttcatc  ttcagcaaa  atggagctt  240
acaggcgag  cttgaaatc  gtgctttga  ggacactgt  gctgtttac  tgacacccg  300
aagcaagtc  agttttaag  aggctttgg  agccctgcc  cagctttcc  gtggagcag  360
taaaaagtt  ctggaagag  tcctgaaca  gttcaagag  agcatgcac  tgcagctca  420
ctgtttcca  gcagcttct  caaccatga  gaaaacata  atatctgcc  cataaaaga  480
gtccaggaa  ataacacgt  ataagactg  tcactctct  agtacccta  aggtatttg  540
tgtattaaa  attgggttt  ccatttttc  cttttttct  cctctgact  cgaaaattg  600
tggtataca  ttcaaccaa  atgacctca  ttgaaatgc  caggaagta  ttgttttgc  660
attcttact  gatcagatc  tgtatgact  taaaataca  tttaaaata  attttgcat  720
tcagcagaa  gttgagtgc  gcaggaaga  ctgcttctg  agggagttt  ctggaatgg  780
gtggcacat  ttgaagcat  tctcagtgt  ccgttcacg  aagcgcagg  agctcccac  840
acacacgga  agactgact  atacgagat  tggaaagct  tgtagacat  tttggagct  900
ttactgtcc  aaactgtac  gctgtgctt  aaaccctta  ttcatataa  tggccttaa  960
ttttctaat  caagcgggt  tttggaaaa  tttatggtc  ccattaaaa  acatattac  1020
actggggta  attatttgt  gtccaggtg  ctgtgattt  actttgcgt  ttgctatct  1080
atttttatt  ttcacaggg  taagcatga  ctttcattc  cactcactc  taatttgtc  1140
tgcgtcact  cacatgcac  tgttgcagt  cctgaggcc  tgtgtgtta  ctgtgatgg  1200
gtgtgaatg  gtaacgggc  ctgtgttac  ctctcaggt  ttggcgggg  ggtcgcaga  1260
ttcagggtc  cctaacgga  aggccaggc  ccgcgtgga  ggccaactc  ctgcccgct  1320
cttcagcag  tgactgtct  tgccacttc  tacctgctg  aggatcttg  tcagtagct  1380
gaacaatgc  gctgtcaca  agtctcttc  ctgaaactt  aggatgctc  ttggtcacc  1440
ggcaatggg  gctgtagac  agccgcatg  acttgcccc  cattcactg  tgactggct  1500
cactggaat  ggttcaggt  accgggact  ctctcagag  cagcagccc  cccaactcc  1560
tcataccgt  gcatctgaa  attttcaga  aggaattct  tttggtagt  ggcttgtca  1620
ggttttcaa  tttttctat  gttattttt  aatctcttt  tttaaatgc  aaaattaat  1680
tcctcatta  tgcaagtaa  tttagagca  agtgtagcc  tgtacagtt  ccattattt  1740
aaataaata  atgtgttgg  tcatttggt  tatgggggg  catcatggt  actggaaat  1800
aaagtttaa  ctttcacaa  tgtgcttga  aaagctgtt  agaattgtc  ttcctaagt  1860
tgttaactg  tgtatctaa  tcaactgtg  gctaagttt  aaaactgca  tcatgaatg  1920
ttgtgatat  ttaaatatc  actacagca  attcagcca  taaagaatc  gcctttaaa  1980
aaaaaaaaa  aaaaaacat  c  2001



<210> 685
<211> 924
<212> PRT
<213> Homo sapiens
<308> CAB54145
<400> 685

Met Ser Arg Ser Arg Gln Pro Pro Leu Val Thr Gly Ile Ser Pro Asn 
  1               5                  10                  15
Glu Gly Ile Pro Trp Thr Lys Val Thr Ile Arg Gly Glu Asn Leu Gly 
             20                  25                  30
Thr Gly Pro Thr Asp Leu Ile Gly Leu Thr Ile Cys Gly His Asn Cys 
         35                  40                  45
Leu Leu Thr Ala Glu Trp Met Ser Ala Ser Lys Ile Val Cys Arg Val 
     50                  55                  60
Gly Gln Ala Lys Asn Asp Lys Gly Asp Ile Ile Val Thr Thr Lys Ser 
 65                  70                  75                  80
Gly Gly Arg Gly Thr Ser Thr Val Ser Phe Lys Leu Leu Lys Pro Glu 
                 85                  90                  95
Lys Ile Gly Ile Leu Asp Gln Ser Ala Val Trp Val Asp Glu Met Asn 
             100                105                110
Tyr Tyr Asp Met Arg Thr Asp Arg Asn Lys Gly Ile Pro Pro Leu Ser 
         115                120                125
Leu Arg Pro Ala Asn Pro Leu Gly Ile Glu Ile Glu Lys Ser Lys Phe 
     130                135                140
Ser Gln Lys Asp Leu Glu Met Leu Phe His Gly Met Ser Ala Asp Phe 
 145                150                155                160
Thr Ser Glu Asn Phe Ser Ala Ala Trp Tyr Leu Ile Glu Asn His Ser 
                 165                170                175
Asn Thr Ser Phe Glu Gln Leu Lys Met Ala Val Thr Asn Leu Lys Arg 
             180                185                190
Gln Ala Asn Lys Lys Ser Glu Gly Ser Leu Ala Tyr Val Lys Gly Gly 
         195                200                205
Leu Ser Thr Phe Phe Glu Ala Gln Asp Ala Leu Ser Ala Ile His Gln 
     210                215                220
Lys Leu Glu Ala Asp Gly Thr Glu Lys Val Glu Gly Ser Met Thr Gln 
 225                230                235                240
Lys Leu Glu Asn Val Leu Asn Arg Ala Ser Asn Thr Ala Asp Thr Leu 
                 245                250                255
Phe Gln Glu Val Leu Gly Arg Lys Asp Lys Ala Asp Ser Thr Arg Asn 
             260                265                270
Ala Leu Asn Val Leu Gln Arg Phe Lys Phe Leu Phe Asn Leu Pro Leu 
         275                280                285
Asn Ile Glu Arg Asn Ile Gln Lys Gly Asp Tyr Asp Val Val Ile Asn 
     290                295                300
Asp Tyr Glu Lys Ala Lys Ser Leu Phe Gly Lys Thr Glu Val Gln Val 
 305                310                315                320
Phe Lys Lys Tyr Tyr Ala Glu Val Glu Thr Arg Ile Glu Ala Leu Arg 
                 325                330                335
Glu Leu Leu Leu Asp Lys Leu Leu Glu Thr Pro Ser Thr Leu His Asp 
             340                345                350
Gln Lys Arg Tyr Ile Arg Tyr Leu Ser Asp Leu His Ala Ser Gly Asp 
         355                360                365
Pro Ala Trp Gln Cys Ile Gly Ala Gln His Lys Trp Ile Leu Gln Leu 
     370                375                380
Met His Ser Cys Lys Glu Gly Tyr Val Lys Asp Leu Lys Gly Asn Pro 
 385                390                395                400
Gly Leu His Ser Pro Met Leu Asp Leu Asp Asn Asp Thr Arg Pro Ser 
                 405                410                415
Val Leu Gly His Leu Ser Gln Thr Ala Ser Leu Lys Arg Gly Ser Ser 
             420                425                430
Phe Gln Ser Gly Arg Asp Asp Thr Trp Arg Tyr Lys Thr Pro His Arg 
         435                440                445
Val Ala Phe Val Glu Lys Leu Thr Lys Leu Val Leu Ser Gln Leu Pro 
     450                455                460
Asn Phe Trp Lys Leu Trp Ile Ser Tyr Val Asn Gly Ser Leu Phe Ser 
 465                470                475                480
Glu Thr Ala Glu Lys Ser Gly Gln Ile Glu Arg Ser Lys Asn Val Arg 
                 485                490                495
Gln Arg Gln Asn Asp Phe Lys Lys Met Ile Gln Glu Val Met His Ser 
             500                505                510
Leu Val Lys Leu Thr Arg Gly Ala Leu Leu Pro Leu Ser Ile Arg Asp 
         515                520                525
Gly Glu Ala Lys Gln Tyr Gly Gly Trp Glu Val Lys Cys Glu Leu Ser 
     530                535                540
Gly Gln Trp Leu Ala His Ala Ile Gln Thr Val Arg Leu Thr His Glu 
 545                550                555                560
Ser Leu Thr Ala Leu Glu Ile Pro Asn Asp Leu Leu Gln Thr Ile Gln 
                 565                570                575
Asp Leu Ile Leu Asp Leu Arg Val Arg Cys Val Met Ala Thr Leu Gln 
             580                585                590
His Thr Ala Glu Glu Ile Lys Arg Leu Ala Glu Lys Glu Asp Trp Ile 
         595                600                605
Val Asp Asn Glu Gly Leu Thr Ser Leu Pro Cys Gln Phe Glu Gln Cys 
     610                615                620
Ile Val Cys Ser Leu Gln Ser Leu Lys Gly Val Leu Glu Cys Lys Pro 
 625                630                635                640
Gly Glu Ala Ser Val Phe Gln Gln Pro Lys Thr Gln Glu Glu Val Cys 
                 645                650                655
Gln Leu Ser Ile Asn Ile Met Gln Val Phe Ile Tyr Cys Leu Glu Gln 
             660                665                670
Leu Ser Thr Lys Pro Asp Ala Asp Ile Asp Thr Thr His Leu Ser Val 
         675                680                685
Asp Val Ser Ser Pro Asp Leu Phe Gly Ser Ile His Glu Asp Phe Ser 
     690                695                700
Leu Thr Ser Glu Gln Arg Leu Leu Ile Val Leu Ser Asn Cys Cys Tyr 
 705                710                715                720
Leu Glu Arg His Thr Phe Leu Asn Ile Ala Glu His Phe Glu Lys His 
                 725                730                735
Asn Phe Gln Gly Ile Glu Lys Ile Thr Gln Val Ser Met Ala Ser Leu 
             740                745                750
Lys Glu Leu Asp Gln Arg Leu Phe Glu Asn Tyr Ile Glu Leu Lys Ala 
         755                760                765
Asp Pro Ile Val Gly Ser Leu Glu Pro Gly Ile Tyr Ala Gly Tyr Phe 
     770                775                780
Asp Trp Lys Asp Cys Leu Pro Pro Thr Gly Val Arg Asn Tyr Leu Lys 
 785                790                795                800
Glu Ala Leu Val Asn Ile Ile Ala Val His Ala Glu Val Phe Thr Ile 
                 805                810                815
Ser Lys Glu Leu Val Pro Arg Val Leu Ser Lys Val Ile Glu Ala Val 
             820                825                830
Ser Glu Glu Leu Ser Arg Leu Met Gln Cys Val Ser Ser Phe Ser Lys 
         835                840                845
Asn Gly Ala Leu Gln Ala Arg Leu Glu Ile Cys Ala Leu Arg Asp Thr 
     850                855                860
Val Ala Val Tyr Leu Thr Pro Glu Ser Lys Ser Ser Phe Lys Gln Ala 
 865                870                875                880
Leu Glu Ala Leu Pro Gln Leu Ser Ser Gly Ala Asp Lys Lys Leu Leu 
                 885                890                895
Glu Glu Leu Leu Asn Lys Phe Lys Ser Ser Met His Leu Gln Leu Thr 
             900                905                910
Cys Phe Gln Ala Ala Ser Ser Thr Met Met Lys Thr 
         915                920



<210> 686
<211> 4358
<212> DNA
<213> Rattus norvegicus
<308> AF032666
<400> 686

actgctgcg  cccggagcg  gttggcccg  acctgacgc  gcctgcaag  tgcaggaca  60
agggctgga  atggcagat  ccaggagct  gcagccagc  cagccgaat  gtgtctcca  120
ctggagtgc  ggagagaga  actgaaaac  aaaaaggtt  cttttataa  tggaacagg  180
gtttgctgc  caaagtaca  tgtctcgat  ccggcagcc  ccacttgtg  caggcatct  240
tccaaatga  gggattcct  ggaccaaag  cacaattag  ggggagaat  tgggtactg  300
tcccactga  cttataggc  tgacaattt  tggacataa  tgcctcctc  cggcagaat  360
gatgtctgc  agtaaaatt  tctgtcgag  gggacaagc  aaaaatgac  aaggagaca  420
tattgtcac  accaagtca  ggggcagag  aacctcaac  gtctctttt  agctactca  480
acctgaaaa  ataggcatt  tggatcagt  tgcagtgtg  gtggatgag  tgaattatt  540
tgatatgcg  actgacagg  ataagggga  tcccccctt  tcacttcgt  ctgcgaatc  600
tctcggcat  gaaattgag  agtgtaaac  tcctcagaa  aacttagaa  tgttattcc  660
tggcatgag  gctgatttt  cgagtgaga  tttttcagc  gcctggtat  tcatagaga  720
ccactccaa  accagtttt  agcagctca  gatggcagt  accaacctc  aaaggcagg  780
caacaagaa  agcgagggt  gtctagcgt  cgtgaaggg  ggcctcagt  ccttctttg  840
agctcaaga  gctctctca  ctatccatc  aaaactaga  gcagacgga  cagaaaaag  900
agaaggatc  atgacacag  aattggaga  tgtcctcaa  agagcaagt  atactgctg  960
cacattgtt  caagaagtg  taggtcgga  agacaaggc  gattccact  ggaatgcac  1020
caacgtgct  cagcggttt  aatttctct  caaccttcc  ctcaatatc  aacggaaca  1080
tcaaaaggg  gattatgat  tggttatta  tgattatga  aaagccaaa  cgctctttg  1140
gaaaacgga  gtgcaagtt  tcaagaaat  ttatgctga  gtagaggca  gaattgaag  1200
tctaagaga  ttacttcta  agaaactgc  cgagactcc  tcaacctta  atgaccaga  1260
gcgttacat  aggtatctt  ctgacctcc  tgctcctgg  gatcctgct  ggcagtgta  1320
cggagctca  cacaagtgg  ccctcaaac  catgcaaga  tgcaaagaa  gccacatga  1380
gagcctgaa  ggtaaccca  gcccacaca  ccccatgct  gacctagat  atgatgccc  1440
cccctctgt  ttgggccat  tcagtcaga  agcatcact  aagagaggc  gcagcttcc  1500
gtctggtcg  gatgacaca  ggaggtaca  gacgcccca  agagtggca  ttgttgaaa  1560
attaacgaa  cttgtgtta  gtcagctgc  taacttctg  aaactctgg  tttcatatg  1620
taatggaag  ctgttcagt  agacagctg  gaagtcagg  cagattgaa  gatcaaaga  1680
tgtgaggca  agacaaaat  atttcaaga  aatgattca  gaagtaatg  actccctgg  1740
gaagttgat  cggggagcc  tgctcccat  cagcctccg  gaaggggat  ggagacagt  1800
tggcggctg  gaggtgcag  cagagctct  ggggcagtg  ctcgcacac  ttatccaga  1860
cataaggct  acatatgaa  cactgaccg  tctggagat  cccaatgac  tgttacaga  1920
tatccagga  ctgattttg  atctccgta  acattgcat  atggtgacg  tgcaacata  1980
agctgaaga  ataaagaga  tagctgaaa  agaagattg  attgttgat  acgaaggac  2040
gacttccct  ccatgtcag  ttgaacaga  cattgttca  tccctgcag  cgttgaagg  2100
tgttgtgga  tgcaaacct  gagaagcca  tgtctttca  cagcctaaa  cccaggagg  2160
ggtttgcca  ttgtgcatc  gtatcatgc  ggtttttat  tactgcctg  aacaactga  2220
caccaagcc  gatgcggac  tagatacta  tcatctttc  gttgatgtt  cttctcctg  2280
tttgtttgg  agcatccat  aagacttcg  tttgacttc  gagcagagg  ttttgatag  2340
cctgagtaa  tgctgctat  tagaacgtc  caccttcct  aacatagca  aacattttg  2400
aaagcacaa  ttccaggga  tagaaaaaa  aacacaggt  agtatggca  cactgaaag  2460
actggatca  cgactcttt  aaaattaca  tgagctaaa  gcagatcct  ttgttggat  2520
cttggaaac  gggatatat  caggctatt  tgattggaa  gactgtctg  ctccagcag  2580
tgtcagaaa  tatttaaaa  aagcactgg  gaatataat  gctgtgcat  cagaggtgt  2640
cactatttc  aaagaactg  tgccccggg  cctggccag  gtgatagaa  cagtctctg  2700
agagctgag  cggctgatg  agtgtgtct  atccttcag  agaaatgga  cgctgcagg  2760
cagacttga  atctgtgct  tgagggaca  tgtagccat  tacctgacc  cggagagca  2820
gtctagttt  aaacaggcc  tggaggccc  gcctcagct  gcaagtggt  cagacaaaa  2880
gctactgga  gagctgctc  acaagttca  gagcagtat  cacttgcag  tcacctgct  2940
ccaagctgc  tctccaaca  tgatgaaga  atagacaca  acagagatc  cagtccaag  3000
actgcattt  ccttctctc  tttccccag  atggtggtg  agaaagatg  tgatgggta  3060
ttaatttca  ccgatttag  ctaccatac  attttgtta  tactagctt  ggtcctgta  3120
catactctt  aaaatgttt  ttcttagct  tatgtttct  ggtgtgagt  ttgagagct  3180
ctccagcat  gcccaaagc  gccnatggt  tgtgtgaat  tgctncgca  tggcgctct  3240
cctggcctc  gtgttggca  tttccagcc  aggggagga  atgaagtca  agcttttgg  3300
gctgtcata  actttaaac  caccatttc  aacaagtgg  tctaggtgc  ctctctctc  3360
ctctctctc  ctctctctc  ctctctctg  aaagaaaaa  ataaaaatg  taaaatctg  3420
gatgcagaa  tccctggat  aactctgaa  ttcatagtc  ggctttcat  tttcccagt  3480
ttcaacacg  aagcttctg  ttctcaccc  taagttgat  catcgttgt  gggagggtt  3540
acaaggacc  gaatgtgga  gccctgtca  acccgcaag  cctgtggca  gcttgtggt  3600
ttcaatgca  cctaaagat  aagccaggc  cctcccctc  cgcaggtta  tcccctctg  3660
tactttcca  acttcgaaa  gtcttgctc  atagctgga  agatggtgc  ctggcacag  3720
ctgtgtttt  taaagatta  aggtgcctc  gtgaccagg  attgagcag  gactcactg  3780
tcactggct  gcacagtag  atctggtca  tgcgacctg  aagcagctt  tacctcact  3840
catctgacc  tagcttcag  tctggttca  tccagacag  tctgtggcg  ctttctttc  3900
gttgacaaa  ttcctgtca  ttttagttc  ggtaattcc  gagcacagc  tatgcacac  3960
atggattat  tgaggttaa  aacagtgtg  ttatttatc  cagtaactg  aagtacaaa  4020
ttaatcctt  gtttgcaaa  tatgtatgt  cagcattgt  tcctcagtg  actggtatt  4080
catctggca  agccaaact  aattccaag  cagaagtac  caactattg  ttgtttaaa  4140
acctaacaa  tacactaca  aaagccagt  gtcttcctt  tctgtaaaa  ctctaagtg  4200
ctttatttc  ccatttttt  ttagctctg  aattgttta  attcctagt  ttaaaatcc  4260
aaataaata  tggtgttct  tctttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  4320
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4358



<210> 687
<211> 924
<212> PRT
<213> Rattus norvegicus
<308> AAC01578
<400> 687

Met Ser Arg Ser Arg Gln Pro Pro Leu Val Thr Gly Ile Ser Pro Asn 
  1               5                  10                  15
Glu Gly Ile Pro Trp Thr Lys Val Thr Ile Arg Gly Glu Asn Leu Gly 
             20                  25                  30
Thr Gly Pro Thr Asp Leu Ile Gly Leu Thr Ile Cys Gly His Asn Cys 
         35                  40                  45
Leu Leu Thr Ala Glu Trp Met Ser Ala Ser Lys Ile Val Cys Arg Val 
     50                  55                  60
Gly Gln Ala Lys Asn Asp Lys Gly Asp Ile Ile Val Thr Thr Lys Ser 
 65                  70                  75                  80
Gly Gly Arg Gly Thr Ser Thr Val Ser Phe Lys Leu Leu Lys Pro Glu 
                 85                  90                  95
Lys Ile Gly Ile Leu Asp Gln Ser Ala Val Trp Val Asp Glu Met Asn 
             100                105                110
Tyr Tyr Asp Met Arg Thr Asp Arg Asn Lys Gly Ile Pro Pro Leu Ser 
         115                120                125
Leu Arg Pro Ala Asn Pro Leu Gly Ile Glu Ile Glu Lys Cys Lys Leu 
     130                135                140
Pro Gln Lys Asn Leu Glu Val Leu Phe His Gly Met Ser Ala Asp Phe 
 145                150                155                160
Thr Ser Glu Asn Phe Ser Ala Ala Trp Tyr Leu Ile Glu Asn His Ser 
                 165                170                175
Asn Thr Ser Phe Glu Gln Leu Lys Met Ala Val Thr Asn Leu Lys Arg 
             180                185                190
Gln Ala Asn Lys Lys Ser Glu Gly Ser Leu Ala Tyr Val Lys Gly Gly 
         195                200                205
Leu Ser Thr Phe Phe Glu Ala Gln Asp Ala Leu Ser Ala Ile His Gln 
     210                215                220
Lys Leu Glu Ala Asp Gly Thr Glu Lys Val Glu Gly Ser Met Thr Gln 
 225                230                235                240
Lys Leu Glu Asn Val Leu Asn Arg Ala Ser Asn Thr Ala Asp Thr Leu 
                 245                250                255
Phe Gln Glu Val Leu Gly Arg Lys Asp Lys Ala Asp Ser Thr Arg Asn 
             260                265                270
Ala Leu Asn Val Leu Gln Arg Phe Lys Phe Leu Phe Asn Leu Pro Leu 
         275                280                285
Asn Ile Lys Arg Asn Ile Gln Lys Gly Asp Tyr Asp Val Val Ile Asn 
     290                295                300
Asp Tyr Glu Lys Ala Lys Ser Leu Phe Gly Lys Thr Glu Val Gln Val 
 305                310                315                320
Phe Lys Lys Tyr Tyr Ala Glu Val Glu Ala Gly Ile Glu Asp Leu Arg 
                 325                330                335
Glu Leu Leu Leu Lys Lys Leu Leu Glu Thr Pro Ser Thr Leu His Asp 
             340                345                350
Gln Lys Arg Tyr Ile Arg Tyr Leu Ser Asp Leu His Ala Pro Gly Asp 
         355                360                365
Pro Ala Trp Gln Cys Ile Gly Ala Gln His Lys Trp Thr Leu Lys Leu 
     370                375                380
Met Gln Asp Cys Lys Glu Gly His Met Lys Ser Leu Lys Gly Asn Pro 
 385                390                395                400
Gly Pro His Ser Pro Met Leu Asp Leu Asp Asn Asp Ala Arg Pro Ser 
                 405                410                415
Val Leu Gly His Leu Ser Gln Thr Ala Ser Leu Lys Arg Gly Ser Ser 
             420                425                430
Phe Gln Ser Gly Arg Asp Asp Thr Trp Arg Tyr Lys Thr Pro His Arg 
         435                440                445
Val Ala Phe Val Glu Lys Leu Thr Lys Leu Val Leu Ser Gln Leu Pro 
     450                455                460
Asn Phe Trp Lys Leu Trp Ile Ser Tyr Val Asn Gly Ser Leu Phe Ser 
 465                470                475                480
Glu Thr Ala Glu Lys Ser Gly Gln Ile Glu Arg Ser Lys Asn Val Arg 
                 485                490                495
Gln Arg Gln Asn Asp Phe Lys Lys Met Ile Gln Glu Val Met His Ser 
             500                505                510
Leu Val Lys Leu Ile Arg Gly Ala Leu Leu Pro Phe Ser Leu Arg Glu 
         515                520                525
Gly Asp Gly Arg Gln Tyr Gly Gly Trp Glu Val Gln Ala Glu Leu Ser 
     530                535                540
Gly Gln Trp Leu Ala His Val Ile Gln Thr Ile Arg Leu Thr Tyr Glu 
 545                550                555                560
Ser Leu Thr Ala Leu Glu Ile Pro Asn Asp Met Leu Gln Ile Ile Gln 
                 565                570                575
Asp Leu Ile Leu Asp Leu Arg Ile His Cys Ile Met Val Thr Leu Gln 
             580                585                590
His Thr Ala Glu Glu Ile Lys Arg Leu Ala Glu Lys Glu Asp Trp Ile 
         595                600                605
Val Asp Asn Glu Gly Leu Thr Ser Leu Pro Cys Gln Phe Glu Gln Ser 
     610                615                620
Ile Val His Ser Leu Gln Ser Leu Lys Gly Val Val Asp Cys Lys Pro 
 625                630                635                640
Gly Glu Ala Ser Val Phe Gln Gln Pro Lys Thr Gln Glu Glu Val Cys 
                 645                650                655
Gln Leu Cys Ile Ser Ile Met Gln Val Phe Ile Tyr Cys Leu Glu Gln 
             660                665                670
Leu Ser Thr Lys Pro Asp Ala Asp Ile Asp Thr Thr His Leu Ser Val 
         675                680                685
Asp Val Ser Ser Pro Asp Leu Phe Gly Ser Ile His Glu Asp Phe Gly 
     690                695                700
Leu Thr Ser Glu Gln Arg Leu Leu Ile Val Leu Ser Asn Cys Cys Tyr 
 705                710                715                720
Leu Glu Arg His Thr Phe Leu Asn Ile Ala Glu His Phe Glu Lys His 
                 725                730                735
Asn Phe Gln Gly Ile Glu Lys Ile Thr Gln Val Ser Met Ala Ser Leu 
             740                745                750
Lys Glu Leu Asp Gln Arg Leu Phe Glu Asn Tyr Ile Glu Leu Lys Ala 
         755                760                765
Asp Pro Ile Val Gly Ser Leu Glu Thr Gly Ile Tyr Ala Gly Tyr Phe 
     770                775                780
Asp Trp Lys Asp Cys Leu Pro Pro Ala Gly Val Arg Asn Tyr Leu Lys 
 785                790                795                800
Glu Ala Leu Val Asn Ile Ile Ala Val His Ala Glu Val Phe Thr Ile 
                 805                810                815
Ser Lys Glu Leu Val Pro Arg Val Leu Ala Arg Val Ile Glu Ala Val 
             820                825                830
Ser Glu Glu Leu Ser Arg Leu Met Gln Cys Val Ser Ser Phe Ser Arg 
         835                840                845
Asn Gly Ala Leu Gln Ala Arg Leu Glu Ile Cys Ala Leu Arg Asp Thr 
     850                855                860
Val Ala Ile Tyr Leu Thr Pro Glu Ser Arg Ser Ser Phe Lys Gln Ala 
 865                870                875                880
Leu Glu Ala Leu Pro Gln Leu Ala Ser Gly Ala Asp Lys Lys Leu Leu 
                 885                890                895
Glu Glu Leu Leu Asn Lys Phe Lys Ser Ser Met His Leu Gln Leu Thr 
             900                905                910
Cys Phe Gln Ala Ala Ser Pro Thr Val Met Lys Thr 
         915                920



<210> 688
<211> 2001
<212> DNA
<213> Homo sapiens
<308> AJ420556
<400> 688

ggcacgagg  gaacctgga  tttatgcag  atattttga  tggaaggac  gcctgcctc  60
aacaggtgt  agaaactat  taaaagaag  actggtgaa  ataattgcc  tgcatgcag  120
ggtgttcac  atttccaaa  aactggtcc  tcgggtact  tccaaggtg  tagaagcag  180
ttctgaaga  ctcagtcga  tgatgcagt  tgtttcatc  ttcagcaaa  atggagctt  240
acaggcgag  cttgaaatc  gtgctttga  ggacactgt  gctgtttac  tgacacccg  300
aagcaagtc  agttttaag  aggctttgg  agccctgcc  cagctttcc  gtggagcag  360
taaaaagtt  ctggaagag  tcctgaaca  gttcaagag  agcatgcac  tgcagctca  420
ctgtttcca  gcagcttct  caaccatga  gaaaacata  atatctgcc  cataaaaga  480
gtccaggaa  ataacacgt  ataagactg  tcactctct  agtacccta  aggtatttg  540
tgtattaaa  attgggttt  ccatttttc  cttttttct  cctctgact  cgaaaattg  600
tggtataca  ttcaaccaa  atgacctca  ttgaaatgc  caggaagta  ttgttttgc  660
attcttact  gatcagatc  tgtatgact  taaaataca  tttaaaata  attttgcat  720
tcagcagaa  gttgagtgc  gcaggaaga  ctgcttctg  agggagttt  ctggaatgg  780
gtggcacat  ttgaagcat  tctcagtgt  ccgttcacg  aagcgcagg  agctcccac  840
acacacgga  agactgact  atacgagat  tggaaagct  tgtagacat  tttggagct  900
ttactgtcc  aaactgtac  gctgtgctt  aaaccctta  ttcatataa  tggccttaa  960
ttttctaat  caagcgggt  tttggaaaa  tttatggtc  ccattaaaa  acatattac  1020
actggggta  attatttgt  gtccaggtg  ctgtgattt  actttgcgt  ttgctatct  1080
atttttatt  ttcacaggg  taagcatga  ctttcattc  cactcactc  taatttgtc  1140
tgcgtcact  cacatgcac  tgttgcagt  cctgaggcc  tgtgtgtta  ctgtgatgg  1200
gtgtgaatg  gtaacgggc  ctgtgttac  ctctcaggt  ttggcgggg  ggtcgcaga  1260
ttcagggtc  cctaacgga  aggccaggc  ccgcgtgga  ggccaactc  ctgcccgct  1320
cttcagcag  tgactgtct  tgccacttc  tacctgctg  aggatcttg  tcagtagct  1380
gaacaatgc  gctgtcaca  agtctcttc  ctgaaactt  aggatgctc  ttggtcacc  1440
ggcaatggg  gctgtagac  agccgcatg  acttgcccc  cattcactg  tgactggct  1500
cactggaat  ggttcaggt  accgggact  ctctcagag  cagcagccc  cccaactcc  1560
tcataccgt  gcatctgaa  attttcaga  aggaattct  tttggtagt  ggcttgtca  1620
ggttttcaa  tttttctat  gttattttt  aatctcttt  tttaaatgc  aaaattaat  1680
tcctcatta  tgcaagtaa  tttagagca  agtgtagcc  tgtacagtt  ccattattt  1740
aaataaata  atgtgttgg  tcatttggt  tatgggggg  catcatggt  actggaaat  1800
aaagtttaa  ctttcacaa  tgtgcttga  aaagctgtt  agaattgtc  ttcctaagt  1860
tgttaactg  tgtatctaa  tcaactgtg  gctaagttt  aaaactgca  tcatgaatg  1920
ttgtgatat  ttaaatatc  actacagca  attcagcca  taaagaatc  gcctttaaa  1980
aaaaaaaaa  aaaaaacat  c  2001



<210> 689
<211> 924
<212> PRT
<213> Homo sapiens
<308> CAB54145
<400> 689

Met Ser Arg Ser Arg Gln Pro Pro Leu Val Thr Gly Ile Ser Pro Asn 
  1               5                  10                  15
Glu Gly Ile Pro Trp Thr Lys Val Thr Ile Arg Gly Glu Asn Leu Gly 
             20                  25                  30
Thr Gly Pro Thr Asp Leu Ile Gly Leu Thr Ile Cys Gly His Asn Cys 
         35                  40                  45
Leu Leu Thr Ala Glu Trp Met Ser Ala Ser Lys Ile Val Cys Arg Val 
     50                  55                  60
Gly Gln Ala Lys Asn Asp Lys Gly Asp Ile Ile Val Thr Thr Lys Ser 
 65                  70                  75                  80
Gly Gly Arg Gly Thr Ser Thr Val Ser Phe Lys Leu Leu Lys Pro Glu 
                 85                  90                  95
Lys Ile Gly Ile Leu Asp Gln Ser Ala Val Trp Val Asp Glu Met Asn 
             100                105                110
Tyr Tyr Asp Met Arg Thr Asp Arg Asn Lys Gly Ile Pro Pro Leu Ser 
         115                120                125
Leu Arg Pro Ala Asn Pro Leu Gly Ile Glu Ile Glu Lys Ser Lys Phe 
     130                135                140
Ser Gln Lys Asp Leu Glu Met Leu Phe His Gly Met Ser Ala Asp Phe 
 145                150                155                160
Thr Ser Glu Asn Phe Ser Ala Ala Trp Tyr Leu Ile Glu Asn His Ser 
                 165                170                175
Asn Thr Ser Phe Glu Gln Leu Lys Met Ala Val Thr Asn Leu Lys Arg 
             180                185                190
Gln Ala Asn Lys Lys Ser Glu Gly Ser Leu Ala Tyr Val Lys Gly Gly 
         195                200                205
Leu Ser Thr Phe Phe Glu Ala Gln Asp Ala Leu Ser Ala Ile His Gln 
     210                215                220
Lys Leu Glu Ala Asp Gly Thr Glu Lys Val Glu Gly Ser Met Thr Gln 
 225                230                235                240
Lys Leu Glu Asn Val Leu Asn Arg Ala Ser Asn Thr Ala Asp Thr Leu 
                 245                250                255
Phe Gln Glu Val Leu Gly Arg Lys Asp Lys Ala Asp Ser Thr Arg Asn 
             260                265                270
Ala Leu Asn Val Leu Gln Arg Phe Lys Phe Leu Phe Asn Leu Pro Leu 
         275                280                285
Asn Ile Glu Arg Asn Ile Gln Lys Gly Asp Tyr Asp Val Val Ile Asn 
     290                295                300
Asp Tyr Glu Lys Ala Lys Ser Leu Phe Gly Lys Thr Glu Val Gln Val 
 305                310                315                320
Phe Lys Lys Tyr Tyr Ala Glu Val Glu Thr Arg Ile Glu Ala Leu Arg 
                 325                330                335
Glu Leu Leu Leu Asp Lys Leu Leu Glu Thr Pro Ser Thr Leu His Asp 
             340                345                350
Gln Lys Arg Tyr Ile Arg Tyr Leu Ser Asp Leu His Ala Ser Gly Asp 
         355                360                365
Pro Ala Trp Gln Cys Ile Gly Ala Gln His Lys Trp Ile Leu Gln Leu 
     370                375                380
Met His Ser Cys Lys Glu Gly Tyr Val Lys Asp Leu Lys Gly Asn Pro 
 385                390                395                400
Gly Leu His Ser Pro Met Leu Asp Leu Asp Asn Asp Thr Arg Pro Ser 
                 405                410                415
Val Leu Gly His Leu Ser Gln Thr Ala Ser Leu Lys Arg Gly Ser Ser 
             420                425                430
Phe Gln Ser Gly Arg Asp Asp Thr Trp Arg Tyr Lys Thr Pro His Arg 
         435                440                445
Val Ala Phe Val Glu Lys Leu Thr Lys Leu Val Leu Ser Gln Leu Pro 
     450                455                460
Asn Phe Trp Lys Leu Trp Ile Ser Tyr Val Asn Gly Ser Leu Phe Ser 
 465                470                475                480
Glu Thr Ala Glu Lys Ser Gly Gln Ile Glu Arg Ser Lys Asn Val Arg 
                 485                490                495
Gln Arg Gln Asn Asp Phe Lys Lys Met Ile Gln Glu Val Met His Ser 
             500                505                510
Leu Val Lys Leu Thr Arg Gly Ala Leu Leu Pro Leu Ser Ile Arg Asp 
         515                520                525
Gly Glu Ala Lys Gln Tyr Gly Gly Trp Glu Val Lys Cys Glu Leu Ser 
     530                535                540
Gly Gln Trp Leu Ala His Ala Ile Gln Thr Val Arg Leu Thr His Glu 
 545                550                555                560
Ser Leu Thr Ala Leu Glu Ile Pro Asn Asp Leu Leu Gln Thr Ile Gln 
                 565                570                575
Asp Leu Ile Leu Asp Leu Arg Val Arg Cys Val Met Ala Thr Leu Gln 
             580                585                590
His Thr Ala Glu Glu Ile Lys Arg Leu Ala Glu Lys Glu Asp Trp Ile 
         595                600                605
Val Asp Asn Glu Gly Leu Thr Ser Leu Pro Cys Gln Phe Glu Gln Cys 
     610                615                620
Ile Val Cys Ser Leu Gln Ser Leu Lys Gly Val Leu Glu Cys Lys Pro 
 625                630                635                640
Gly Glu Ala Ser Val Phe Gln Gln Pro Lys Thr Gln Glu Glu Val Cys 
                 645                650                655
Gln Leu Ser Ile Asn Ile Met Gln Val Phe Ile Tyr Cys Leu Glu Gln 
             660                665                670
Leu Ser Thr Lys Pro Asp Ala Asp Ile Asp Thr Thr His Leu Ser Val 
         675                680                685
Asp Val Ser Ser Pro Asp Leu Phe Gly Ser Ile His Glu Asp Phe Ser 
     690                695                700
Leu Thr Ser Glu Gln Arg Leu Leu Ile Val Leu Ser Asn Cys Cys Tyr 
 705                710                715                720
Leu Glu Arg His Thr Phe Leu Asn Ile Ala Glu His Phe Glu Lys His 
                 725                730                735
Asn Phe Gln Gly Ile Glu Lys Ile Thr Gln Val Ser Met Ala Ser Leu 
             740                745                750
Lys Glu Leu Asp Gln Arg Leu Phe Glu Asn Tyr Ile Glu Leu Lys Ala 
         755                760                765
Asp Pro Ile Val Gly Ser Leu Glu Pro Gly Ile Tyr Ala Gly Tyr Phe 
     770                775                780
Asp Trp Lys Asp Cys Leu Pro Pro Thr Gly Val Arg Asn Tyr Leu Lys 
 785                790                795                800
Glu Ala Leu Val Asn Ile Ile Ala Val His Ala Glu Val Phe Thr Ile 
                 805                810                815
Ser Lys Glu Leu Val Pro Arg Val Leu Ser Lys Val Ile Glu Ala Val 
             820                825                830
Ser Glu Glu Leu Ser Arg Leu Met Gln Cys Val Ser Ser Phe Ser Lys 
         835                840                845
Asn Gly Ala Leu Gln Ala Arg Leu Glu Ile Cys Ala Leu Arg Asp Thr 
     850                855                860
Val Ala Val Tyr Leu Thr Pro Glu Ser Lys Ser Ser Phe Lys Gln Ala 
 865                870                875                880
Leu Glu Ala Leu Pro Gln Leu Ser Ser Gly Ala Asp Lys Lys Leu Leu 
                 885                890                895
Glu Glu Leu Leu Asn Lys Phe Lys Ser Ser Met His Leu Gln Leu Thr 
             900                905                910
Cys Phe Gln Ala Ala Ser Ser Thr Met Met Lys Thr 
         915                920



<210> 690
<211> 3059
<212> DNA
<213> Rattus norvegicus
<308> AF032668
<400> 690

ccgcgtcga  ccggcacaa  cacaccatg  accctgaca  taaatttat  aaaaatttt  60
ttcaactat  gcacaaaaa  tgtgtatca  ttaacaggg  tgacaaatg  ctgtcactt  120
agtcactat  atgcacaat  tatatatgc  ttctactta  gaagcacgt  tactggaaa  180
caactgtta  gcagacggc  tcctcattt  tcttatgtt  ggtctcttg  cccttgaga  240
atcatgtcc  gtaagggat  tacaacagt  ccttgtgtg  gttaacaat  atgaaatca  300
aattgatgt  ttttcctga  tctgtcccc  cagttaaac  atgcctttc  ccccggggc  360
ccgcgcccg  ccggcgcct  cgcttccag  caagatggc  gagagcggc  aggctctgg  420
tacggtccc  gagcacgag  ggatcttgc  ggagatcga  agcacggac  ccgcctgcg  480
agggcccac  cttcggtct  tgtatgatg  tcagccaaa  gcacacaag  agttcatgg  540
aaagctaga  gcctgcatc  gcaaccatg  caaggagat  gagaaaatg  gtaacttcc  600
tcaccaggg  tttgtagat  ctatcacag  gctcctcaa  gtaagggcg  acgcagaaa  660
gctgaaggt  caggttact  ataccaacc  aaggttcca  gatgctgga  aagaggtga  720
agaacaaac  gaagatatt  ttcggtgta  aattcagca  agaaatatt  caaccgtag  780
agagaaatt  cagttatgc  tgccagtgt  ggagatgta  agtaaactg  aggaacaga  840
gagcatgca  aggtattat  ctgcactta  aacaatgga  cagttagag  acgtatact  900
tcctcgggt  agccagtac  gcttctgtc  gctcatgat  gacacactt  ctaaactcc  960
ggaggatat  aaagacatc  ccatgtctg  cctcaagga  tttctggaa  gcattcgaa  1020
gcattctga  aaaataggg  aaacagcca  gaaacaggc  caacagcag  agagcttca  1080
tattgctgt  cagaagcaa  ccaatatga  gtttgggaa  aatatgcat  taaacaatg  1140
caggactct  gaggaaaag  gtgacatca  actgaagca  acacttgag  aggaggccg  1200
gaatgacga  gaggtctta  ctgttcaag  tctcgttga  ttttcccct  tttaccgat  1260
ctcacacat  tattctgct  tgggtgatg  agaaacatt  gaaaattat  accggaagc  1320
aaggaagaa  caggcgcgc  tggttctgc  gccgcagtc  agtgtgcat  aaacagttg  1380
tggctatag  agatatttc  ctcagattg  agggttctt  gttgtggaa  atcacattt  1440
acatgtgac  caaggatta  taaccaggg  atacactga  gaactctgg  acatggccc  1500
ctcaaagat  attgctgtc  tcagagctc  ctcatctta  tgcactgat  ctgaccttg  1560
tctggagct  aagaatctc  tcgtcattt  tgcggatac  ttgcagggt  atggctttt  1620
tgtcaaccg  ctctttgac  ttctatttg  aataagaga  caatacaac  aaacactgc  1680
taagaaatg  gccggtatt  tcagggaca  ttttgaaga  gataactac  gccctattc  1740
tattggcag  gaagaagaa  ataaaatgg  catcagtaa  ttccccttc  aagatccgg  1800
ccttgaaaa  caatccttc  caaagaagt  tcccatgtc  cagtcagtg  ctcttattt  1860
tattcaagt  aaagaattt  tttatgcca  tcttaaatt  tcagagtca  tacaccgaa  1920
ctctacaga  atagacgat  tgcttagga  gtcaacaaa  ctgctgctg  ccaggattc  1980
gagtagctg  ttactgaac  tcattagaa  acctcacat  ggtttgaca  agctggtgc  2040
aattatcat  aacacaaca  acctggagc  ggcttgcaa  tacctggag  actttataa  2100
taacattac  aatatttct  aagaaaccg  tcacaccac  agactttat  gactttcta  2160
ttttaagga  gcacgacat  cagcggaag  agaaatata  accaaactc  atcagaaga  2220
tgatgagtt  gtccagctg  ccgactacg  ctggaccat  gctgagtcg  atgggagag  2280
aagtggtta  ttaatggat  ttattaatt  tttgagaag  atctttcaa  tatttaccc  2340
cttgcctgg  aaagttgcc  agacagctt  catgtcagc  tgccaacat  tgtccacat  2400
cttgatgca  atgctcctg  acagcgagt  aaagcagat  agcatgggg  ccgtacagc  2460
gtttaacct  gacgtcata  agtgcgaat  gtttgccag  tctgagcct  tgccaggat  2520
ccaagggga  accctgcag  tggccttca  tgacctcag  cagctcctt  acttgttta  2580
ggtttggga  tggtctact  acctggctg  ctatgggca  ccagcttcc  agtacctcc  2640
ggtgaaccc  cacgccgcc  ttacgcttt  ggagaagat  aaggacacc  gtaagaaga  2700
taacatatt  gcccagttc  ggaagaacg  ccgggacag  cagaagctg  tcgagacag  2760
ggtgaaaca  ctcagaggc  tggtgaccg  tatgtccca  cacatgtag  ccagatcca  2820
gcccgagtg  ttctctgtg  ccagcaccg  tcatgagac  ataatttgt  tacagaagc  2880
aaaaactgt  gtagaggaa  gatactaat  agggcttaa  caataagga  agcaaacat  2940
atttgtatg  acttttaat  actgaatac  attttatat  taaaaatgt  acattaatt  3000
tttccaatt  tagaagaaa  gtcaaaagt  taatatata  acccaataa  ttgtgtatg  3059



<210> 691
<211> 822
<212> PRT
<213> Rattus norvegicus
<308> AAC01580
<400> 691

Met Pro Phe Ser Pro Gly Arg Arg Ala Arg Pro Ala Pro Pro Leu Pro 
  1               5                  10                  15
Ala Lys Met Ala Glu Ser Gly Glu Ala Leu Gly Thr Val Pro Glu His 
             20                  25                  30
Glu Arg Ile Leu Gln Glu Ile Glu Ser Thr Asp Thr Ala Cys Val Gly 
         35                  40                  45
Pro Thr Leu Arg Ser Val Tyr Asp Gly Gln Pro Asn Ala His Lys Lys 
     50                  55                  60
Phe Met Glu Lys Leu Asp Ala Cys Ile Arg Asn His Asp Lys Glu Ile 
 65                  70                  75                  80
Glu Lys Met Cys Asn Phe His His Gln Gly Phe Val Asp Ala Ile Thr 
                 85                  90                  95
Glu Leu Leu Lys Val Arg Ala Asp Ala Glu Lys Leu Lys Val Gln Val 
             100                105                110
Thr Asp Thr Asn Arg Arg Phe Gln Asp Ala Gly Lys Glu Val Ile Glu 
         115                120                125
Gln Thr Glu Asp Ile Ile Arg Cys Arg Ile Gln Gln Arg Asn Ile Thr 
     130                135                140
Thr Val Val Glu Lys Leu Gln Leu Cys Leu Pro Val Leu Glu Met Tyr 
 145                150                155                160
Ser Lys Leu Lys Glu Gln Met Ser Met Gln Arg Tyr Tyr Ser Ala Leu 
                 165                170                175
Lys Thr Met Glu Gln Leu Glu Asn Val Tyr Phe Pro Arg Val Ser Gln 
             180                185                190
Tyr Arg Phe Cys Gln Leu Met Met Asp Thr Leu Pro Lys Leu Arg Glu 
         195                200                205
Asp Ile Lys Asp Ile Ser Met Ser Asp Leu Lys Asp Phe Leu Glu Ser 
     210                215                220
Ile Arg Lys His Ser Asp Lys Ile Gly Glu Thr Ala Met Lys Gln Ala 
 225                230                235                240
Gln Gln Gln Lys Ser Phe Ser Ile Ala Val Gln Lys Gln Thr Asn Met 
                 245                250                255
Arg Phe Gly Lys Asn Met His Val Asn Asn Asp Arg Thr Leu Glu Glu 
             260                265                270
Lys Ser Asp Ile Ile Leu Lys His Thr Leu Glu Glu Glu Ala Glu Asn 
         275                280                285
Asp Glu Glu Val Leu Thr Val Gln Asp Leu Val Asp Phe Ser Pro Val 
     290                295                300
Tyr Arg Cys Ser His Ile Tyr Ser Ala Leu Gly Asp Glu Glu Thr Phe 
 305                310                315                320
Glu Asn Tyr Tyr Arg Lys Gln Arg Lys Lys Gln Ala Arg Leu Val Leu 
                 325                330                335
Gln Pro Gln Ser Ser Val His Glu Thr Val Asp Gly Tyr Arg Arg Tyr 
             340                345                350
Phe Thr Gln Ile Val Gly Phe Phe Val Val Glu Asp His Ile Leu His 
         355                360                365
Val Thr Gln Gly Leu Val Thr Arg Ala Tyr Thr Asp Glu Leu Trp Asn 
     370                375                380
Met Ala Leu Ser Lys Ile Ile Ala Val Leu Arg Ala His Ser Ser Tyr 
 385                390                395                400
Cys Thr Asp Pro Asp Leu Val Leu Glu Leu Lys Asn Leu Ile Val Ile 
                 405                410                415
Phe Ala Asp Thr Leu Gln Gly Tyr Gly Phe Ser Val Asn Arg Leu Phe 
             420                425                430
Asp Leu Leu Phe Glu Ile Arg Asp Gln Tyr Asn Glu Thr Leu Leu Lys 
         435                440                445
Lys Trp Ala Gly Ile Phe Arg Asp Ile Phe Glu Glu Asp Asn Tyr Ser 
     450                455                460
Pro Ile Pro Ile Gly Ser Glu Glu Glu Tyr Lys Met Val Ile Ser Lys 
 465                470                475                480
Phe Pro Phe Gln Asp Pro Asp Leu Glu Lys Gln Ser Phe Pro Lys Lys 
                 485                490                495
Phe Pro Met Ser Gln Ser Val Pro Leu Ile Tyr Ile Gln Val Lys Glu 
             500                505                510
Phe Ile Tyr Ala Ser Leu Lys Phe Ser Glu Ser Leu His Arg Ser Ser 
         515                520                525
Thr Glu Ile Asp Asp Met Leu Arg Lys Ser Thr Asn Leu Leu Leu Thr 
     530                535                540
Arg Ile Leu Ser Ser Cys Leu Leu Asn Leu Ile Arg Lys Pro His Ile 
 545                550                555                560
Gly Leu Thr Glu Leu Val Gln Ile Ile Ile Asn Thr Thr His Leu Glu 
                 565                570                575
Gln Ala Cys Lys Tyr Leu Glu Asp Phe Ile Thr Asn Ile Thr Asn Ile 
             580                585                590
Ser Gln Glu Thr Val His Thr Thr Arg Leu Tyr Gly Leu Ser Thr Phe 
         595                600                605
Lys Asp Ala Arg His Ala Ala Glu Gly Glu Ile Tyr Thr Lys Leu Asn 
     610                615                620
Gln Lys Ile Asp Glu Phe Val Gln Leu Ala Asp Tyr Asp Trp Thr Met 
 625                630                635                640
Ala Glu Ser Asp Gly Arg Ala Ser Gly Tyr Leu Met Asp Leu Ile Asn 
                 645                650                655
Phe Leu Arg Ser Ile Phe Gln Val Phe Thr His Leu Pro Gly Lys Val 
             660                665                670
Ala Gln Thr Ala Cys Met Ser Ala Cys Gln His Leu Ser Thr Ser Leu 
         675                680                685
Met Gln Met Leu Leu Asp Ser Glu Leu Lys Gln Ile Ser Met Gly Ala 
     690                695                700
Val Gln Gln Phe Asn Leu Asp Val Ile Gln Cys Glu Leu Phe Ala Ser 
 705                710                715                720
Ser Glu Pro Val Pro Gly Phe Gln Gly Asp Thr Leu Gln Leu Ala Phe 
                 725                730                735
Ile Asp Leu Arg Gln Leu Leu Asp Leu Phe Met Val Trp Asp Trp Ser 
             740                745                750
Thr Tyr Leu Ala Asp Tyr Gly Gln Pro Ala Ser Lys Tyr Leu Arg Val 
         755                760                765
Asn Pro His Ala Ala Leu Thr Leu Leu Glu Lys Met Lys Asp Thr Ser 
     770                775                780
Lys Lys Asn Asn Ile Phe Ala Gln Phe Arg Lys Asn Asp Arg Asp Arg 
 785                790                795                800
Gln Lys Leu Ile Glu Thr Val Val Lys Gln Leu Arg Gly Leu Val Thr 
                 805                810                815
Gly Met Ser Gln His Met 
             820



<210> 692
<211> 1799
<212> DNA
<213> Homo sapiens
<308> AK002113
<400> 692

acaaagaaa  aaacaagca  gactggtat  gcaacccca  tcgaatatg  atgaaacag  60
tgatggcta  agaagatat  tcactcaaa  tgtagggtt  tttgtggta  aagatcaca  120
tttacatgt  acccaagga  tagtaacca  ggcatacac  gatgaactt  ggaacatgg  180
cctctcaaa  ataattgct  tccttagag  tcattcatc  tattgcact  atcctgatc  240
tgttctgga  ctgaagaat  ttattgtaa  atttgcaga  actttacag  gttatggtt  300
tccagtgaa  cgacttttt  accttttat  tgaaataag  gaccaatac  atgaaacac  360
gcttaagaa  tgggctgga  ttttcaggg  catttttga  gaagataat  acagcccca  420
ccctgttgt  aatgaagaa  aatataaaa  tgtcatcag  aaatttccc  ttcaagatc  480
agaccttga  aagcagtct  tcccaaaga  attccccat  tctcagtca  tgcctcata  540
ttacattca  gttaaagaa  ttatttatg  cagccttaa  ttttcagag  cactacacc  600
gagctcaac  gaaatagac  atatgctta  aaaatcaac  aatctgctg  tgaccagaa  660
tttgagtag  tgtttactg  accttatta  aaaacctca  ataggtttg  cagagctgg  720
acaaatcat  ataaacaca  cacacctgg  gcaagcttg  aaatatctt  aggacttta  780
aactaacat  acaaatatt  cccaagaaa  tgttcatac  acaagactt  atggacttt  840
tactttcaa  gatgctcga  atgcagcag  aggagaaat  tataccaaa  tgaatcaaa  900
aattgatga  tttgttcag  ttgctgatt  tgactggac  atgtctgag  cagatggaa  960
agctagtgg  tatttaatg  accttataa  ttttttgag  agcatcttt  aagtgttta  1020
tcatttgcc  gggaaagtt  ctcagacag  ttgcatgtc  gcctgccag  atctgtcaa  1080
atccttaat  cagatgcta  tggacagtg  gttaaaaca  ataagcatg  gagctgttc  1140
gcagtttaa  ttagatgtc  tacagtgtg  atatgaggt  ttgctgtgt  gcccagact  1200
gtctcaaac  cctggcctc  agtcatcct  ctgccttgg  atcccaaaa  gctggaatt  1260
gaggcgtga  ctactgtgc  tggccattt  tataagctt  taagctgaa  tgtttgcca  1320
ctctgagcc  gtgccagga  tccaggggg  taccctgca  ctagcattc  ttgacctca  1380
acaactcct  gacctgttt  tggtttggg  ttggtctac  tacctagct  attatgggc  1440
gccagcttc  aagtacctt  gggtgaatc  aaacacagc  cttactctt  tggagaaga  1500
gaaggatac  agcaaaaag  acaatatat  tgctcagtt  aggaagaat  atcgagaca  1560
acagaagtt  atagagaca  tcgtgaaac  gctgagaag  ttggtgaat  gtatgtccc  1620
gcacatgta  acctcacat  gcttgcact  agtgacacc  aatccatga  tcaatgttg  1680
tcttgagca  gtattggtc  tgatacagt  atttgttta  agaatccaa  aatacaata  1740
agaagatac  tgagggctt  aacaagaaa  agtaataaa  atcatttgt  tggattttt  1799



<210> 693
<211> 596
<212> PRT
<213> Homo sapiens
<308> CAB70736
<400> 693

Lys His Ser Asp Lys Ile Gly Glu Thr Ala Met Lys Gln Ala Gln His 
  1               5                  10                  15
Gln Lys Thr Phe Ser Val Ser Leu Gln Lys Gln Asn Lys Met Lys Phe 
             20                  25                  30
Gly Lys Asn Met Tyr Ile Asn Arg Asp Arg Ile Pro Glu Glu Arg Asn 
         35                  40                  45
Glu Thr Val Leu Lys His Ser Leu Glu Glu Glu Asp Glu Asn Glu Glu 
     50                  55                  60
Glu Ile Leu Thr Val Gln Asp Leu Val Asp Phe Ser Pro Val Tyr Arg 
 65                  70                  75                  80
Cys Leu His Ile Tyr Ser Val Leu Gly Asp Glu Glu Thr Phe Glu Asn 
                 85                  90                  95
Tyr Tyr Arg Lys Gln Arg Lys Lys Gln Ala Arg Leu Val Leu Gln Pro 
             100                105                110
Gln Ser Asn Met His Glu Thr Val Asp Gly Tyr Arg Arg Tyr Phe Thr 
         115                120                125
Gln Ile Val Gly Phe Phe Val Val Glu Asp His Ile Leu His Val Thr 
     130                135                140
Gln Gly Leu Val Thr Arg Ala Tyr Thr Asp Glu Leu Trp Asn Met Ala 
 145                150                155                160
Leu Ser Lys Ile Ile Ala Val Leu Arg Ala His Ser Ser Tyr Cys Thr 
                 165                170                175
Asp Pro Asp Leu Val Leu Glu Leu Lys Asn Leu Thr Val Ile Phe Ala 
             180                185                190
Asp Thr Leu Gln Gly Tyr Gly Phe Pro Val Asn Arg Leu Phe Asp Leu 
         195                200                205
Leu Phe Glu Ile Arg Asp Gln Tyr Asn Glu Thr Leu Leu Lys Lys Trp 
     210                215                220
Ala Gly Val Phe Arg Asp Ile Phe Glu Glu Asp Asn Tyr Ser Pro Ile 
 225                230                235                240
Pro Val Val Asn Glu Glu Glu Tyr Lys Ile Val Ile Ser Lys Phe Pro 
                 245                250                255
Phe Gln Asp Pro Asp Leu Glu Lys Gln Ser Phe Pro Lys Lys Phe Pro 
             260                265                270
Met Ser Gln Ser Val Pro His Ile Tyr Ile Gln Val Lys Glu Phe Ile 
         275                280                285
Tyr Ala Ser Leu Lys Phe Ser Glu Ser Leu His Arg Ser Ser Thr Glu 
     290                295                300
Ile Asp Asp Met Leu Arg Lys Ser Thr Asn Leu Leu Leu Thr Arg Thr 
 305                310                315                320
Leu Ser Ser Cys Leu Leu Asn Leu Ile Arg Lys Pro His Ile Gly Leu 
                 325                330                335
Thr Glu Leu Val Gln Ile Ile Ile Asn Thr Thr His Leu Glu Gln Ala 
             340                345                350
Cys Lys Tyr Leu Glu Asp Phe Ile Thr Asn Ile Thr Asn Ile Ser Gln 
         355                360                365
Glu Thr Val His Thr Thr Arg Leu Tyr Gly Leu Ser Thr Phe Lys Asp 
     370                375                380
Ala Arg His Ala Ala Glu Gly Glu Ile Tyr Thr Lys Leu Asn Gln Lys 
 385                390                395                400
Ile Asp Glu Phe Val Gln Leu Ala Asp Tyr Asp Trp Thr Met Ser Glu 
                 405                410                415
Pro Asp Gly Arg Ala Ser Gly Tyr Leu Met Asp Leu Ile Asn Phe Leu 
             420                425                430
Arg Ser Ile Phe Gln Val Phe Thr His Leu Pro Gly Lys Val Ala Gln 
         435                440                445
Thr Ala Cys Met Ser Ala Cys Gln His Leu Ser Thr Ser Leu Met Gln 
     450                455                460
Met Leu Leu Asp Ser Glu Leu Lys Gln Ile Ser Met Gly Ala Val Gln 
 465                470                475                480
Gln Phe Asn Leu Asp Val Ile Gln Cys Glu Leu Phe Ala Ser Ser Glu 
                 485                490                495
Pro Val Pro Gly Phe Gln Gly Asp Thr Leu Gln Leu Ala Phe Ile Asp 
             500                505                510
Leu Arg Gln Leu Leu Asp Leu Phe Met Val Trp Asp Trp Ser Thr Tyr 
         515                520                525
Leu Ala Asp Tyr Gly Gln Pro Ala Ser Lys Tyr Leu Arg Val Asn Pro 
     530                535                540
Asn Thr Ala Leu Thr Leu Leu Glu Lys Met Lys Asp Thr Ser Lys Lys 
 545                550                555                560
Asn Asn Ile Phe Ala Gln Phe Arg Lys Asn Asp Arg Asp Lys Gln Lys 
                 565                570                575
Leu Ile Glu Thr Val Val Lys Gln Leu Arg Ser Leu Val Asn Gly Met 
             580                585                590
Ser Gln His Met 
         595



<210> 694
<211> 597
<212> DNA
<213> Rattus norvegicus
<308> AF033027
<400> 694

atgaagctg  acagcctca  cgtcctcta  aaaggcgag  agaaagcgg  tctgctcaa  60
gccgcgtac  acgtgtctt  ctttagttt  ttccagagg  ccagtgttc  ggaattcat  120
acctttaca  gtcaactga  tgtggaacg  tcggcgaaa  gcagcagag  ttctgttaa  180
gaacaagag  acctttgcc  tgtctacgt  cggagtgac  gtctggcag  tgtggtcat  240
gctgacagc  aataccctt  cagagtggc  tttaccttg  tggagaagg  actagatca  300
ttctccaag  aggtcgata  aatagactg  ccagtagga  cccctgcta  aatccatta  360
acagcccta  atggccacc  tagtagata  cagaacccc  gggaggctg  tcccatgag  420
aaagtgcag  ccgaactgg  tgagaccaa  atcattctg  acaacacca  ggagtcttt  480
ttagagcga  gggagaagc  tgatgactt  gtatccaaa  cagaagtcc  gggaacaca  540
tcgaaagcc  tctataaaa  tgcccggaa  caaaactca  gctgtgcaa  catgtga  597



<210> 695
<211> 199
<212> PRT
<213> Rattus norvegicus
<308> AF033027
<400> 695

Met Lys Leu Tyr Ser Leu Ser Val Leu Tyr Lys Gly Glu Lys Lys Ala 
  1               5                  10                  15
Val Leu Leu Lys Ala Ala Tyr Asp Val Ser Ser Phe Ser Phe Phe Gln 
             20                  25                  30
Arg Ser Ser Val Gln Glu Phe Met Thr Phe Thr Ser Gln Leu Ile Val 
         35                  40                  45
Glu Arg Ser Ala Lys Gly Ser Arg Ala Ser Val Lys Glu Gln Glu Tyr 
     50                  55                  60
Leu Cys His Val Tyr Val Arg Ser Asp Ser Leu Ala Gly Val Val Ile 
 65                  70                  75                  80
Ala Asp Ser Glu Tyr Pro Ser Arg Val Ala Phe Thr Leu Leu Glu Lys 
                 85                  90                  95
Val Leu Asp Gln Phe Ser Lys Gln Val Asp Thr Ile Asp Trp Pro Val 
             100                105                110
Gly Ser Pro Ala Thr Ile His Tyr Thr Ala Leu Asp Gly His Leu Ser 
         115                120                125
Arg Tyr Gln Asn Pro Arg Glu Ala Asp Pro Met Ser Lys Val Gln Ala 
     130                135                140
Glu Leu Asp Glu Thr Lys Ile Ile Leu His Asn Thr Met Glu Ser Leu 
 145                150                155                160
Leu Glu Arg Gly Glu Lys Leu Asp Asp Leu Val Ser Lys Ser Glu Val 
                 165                170                175
Leu Gly Thr Gln Ser Lys Ala Phe Tyr Lys Thr Ala Arg Lys Gln Asn 
             180                185                190
Ser Cys Cys Ala Ile Met Ter 
         195



<210> 696
<211> 741
<212> DNA
<213> Homo sapiens
<308> U95735
<400> 696

gctgcttcc  tgagaacgg  tcccgcagc  gggcaggcg  gcggcctga  ggccggacc  60
tgaagctgt  cagcctcag  gtcctctac  aaggcgagg  caaggtggt  ctgctcaaa  120
ccgcatacg  tgtgtcttc  ttcagcttt  tccagagat  cagcgttca  gaattcatg  180
ccttcacga  tcaactgat  gtggagcgc  catcgaaag  cactagagc  tctgtcaaa  240
aacaagact  tctgtgcca  gtctacgtc  ggaatgata  tcttgcagg  gtggtcatt  300
ctgacaatg  atacccatc  cgggtggcc  ttaccttgc  ggagaaggt  ctagatgaa  360
tctccaagc  agtcgacag  atagactgg  cagtaggat  ccctgctac  atccattac  420
cagccctgg  tggtcacct  agtagatac  agaacccac  agaagctga  cccatgact  480
aagtgcagg  cgaactaga  gagaccaaa  tcattctgc  caacaccat  gagtctctg  540
tagagcgag  tgagaagct  gatgacttg  tgtccaaat  cgaggtgct  ggaacacag  600
ctaaagcct  ctataaaac  gcccggaaa  aaaactcat  ctgtgccat  atgtgatgc  660
gcctccaga  gcccaatgc  ggaatggca  catcattca  atcagaact  cagcccctg  720
aaaagaaga  acatcgttc  t  741



<210> 697
<211> 220
<212> PRT
<213> Homo sapiens
<308> P51809
<400> 697

Met Ala Ile Leu Phe Ala Val Val Ala Arg Gly Thr Thr Ile Leu Ala 
  1               5                  10                  15
Lys His Ala Trp Cys Gly Gly Asn Phe Leu Glu Val Thr Glu Gln Ile 
             20                  25                  30
Leu Ala Lys Ile Pro Ser Glu Asn Asn Lys Leu Thr Tyr Ser His Gly 
         35                  40                  45
Asn Tyr Leu Phe His Tyr Ile Cys Gln Asp Arg Ile Val Tyr Leu Cys 
     50                  55                  60
Ile Thr Asp Asp Asp Phe Glu Arg Ser Arg Ala Phe Asn Phe Leu Asn 
 65                  70                  75                  80
Glu Ile Lys Lys Arg Phe Gln Thr Thr Tyr Gly Ser Arg Ala Gln Thr 
                 85                  90                  95
Ala Leu Pro Tyr Ala Met Asn Ser Glu Phe Ser Ser Val Leu Ala Ala 
             100                105                110
Gln Leu Lys His His Ser Glu Asn Lys Gly Leu Asp Lys Val Met Glu 
         115                120                125
Thr Gln Ala Gln Val Asp Glu Leu Lys Gly Ile Met Val Arg Asn Ile 
     130                135                140
Asp Leu Val Ala Gln Arg Gly Glu Arg Leu Glu Leu Leu Ile Asp Lys 
 145                150                155                160
Thr Glu Asn Leu Val Asp Ser Ser Val Thr Phe Lys Thr Thr Ser Arg 
                 165                170                175
Asn Leu Ala Arg Ala Met Cys Met Lys Asn Leu Lys Leu Thr Ile Ile 
             180                185                190
Ile Ile Ile Val Ser Ile Val Phe Ile Tyr Ile Ile Val Ser Pro Leu 
         195                200                205
Cys Gly Gly Phe Thr Trp Pro Ser Cys Val Lys Lys 
     210                215                220



<210> 698
<211> 859
<212> DNA
<213> Rattus norvegicus
<308> AF033109
<400> 698

gcacgagct  caggcggag  ctgcaccat  gccccagac  cctggttct  cacgtacga  60
tctacttgt  agattgccc  agaaatcgc  gagaagatt  aagaacgaa  tcagtgtga  120
agaagaggt  agaagacac  taagcttac  ctgacaatc  gaactttgt  gaagaatct  180
aaggtaaag  tcgacctct  gaaggactt  cttctaaga  ctgtgtcga  gcgccagat  240
acacaactg  agggggatc  aagacagaa  cttctggat  atcttgtca  ccgagagag  300
ctgctcctg  catcgttta  gaatgaggg  tccgagccg  atttgatca  gtccagcct  360
atgagtgaa  aagcaaagc  aggaactcc  aacccttgg  tctgtgagg  gccggagga  420
accagaggc  tgggtttcg  tgagatccg  caacagcag  agaaaatta  tcaagaaca  480
gacgcaggt  ttgatgccc  ttcctctat  ataagtcgc  aaaagcaaa  gggccagga  540
attgggaat  aactggacg  acagaacga  atcatcgat  accttgcca  cctggtgga  600
aacacagat  agaagcttc  cactgaagc  aggcgagtg  ccctggtgg  cagaaagtc  660
gcttcctgt  ggatgataa  ggtgatctt  ttgctgctc  tggctattg  ggtggttgc  720
gtgtggcca  ccaactgat  gcaataagg  gaccacccg  agtgacaca  ccaacaatg  780
gtgaaagcc  agcaccctt  tggtacaca  cacctcctc  caataaatt  tccacgctc  840
cggcaaaaa  aaaaaaaaa  859



<210> 699
<211> 236
<212> PRT
<213> Rattus norvegicus
<308> Q9Z2Q7
<400> 699

Met Ala Pro Asp Pro Trp Phe Ser Thr Tyr Asp Ser Thr Cys Gln Ile 
  1               5                  10                  15
Ala Gln Glu Ile Ala Glu Lys Ile Gln Glu Arg Asn Gln Cys Glu Arg 
             20                  25                  30
Arg Gly Glu Lys Thr Pro Lys Leu Thr Leu Thr Ile Arg Thr Leu Leu 
         35                  40                  45
Lys Asn Leu Lys Val Lys Ile Asp Leu Leu Lys Asp Leu Leu Leu Arg 
     50                  55                  60
Ala Val Ser Thr Arg Gln Ile Thr Gln Leu Glu Gly Asp Arg Arg Gln 
 65                  70                  75                  80
Asn Leu Leu Asp Asp Leu Val Thr Arg Glu Arg Leu Leu Leu Ala Ser 
                 85                  90                  95
Phe Lys Asn Glu Gly Ser Glu Pro Asp Leu Ile Arg Ser Ser Leu Met 
             100                105                110
Ser Glu Glu Ala Lys Arg Gly Thr Pro Asn Pro Trp Leu Cys Glu Glu 
         115                120                125
Pro Glu Glu Thr Arg Gly Leu Gly Phe Asp Glu Ile Arg Gln Gln Gln 
     130                135                140
Gln Lys Ile Ile Gln Glu Gln Asp Ala Gly Leu Asp Ala Leu Ser Ser 
 145                150                155                160
Ile Ile Ser Arg Gln Lys Gln Met Gly Gln Glu Ile Gly Asn Glu Leu 
                 165                170                175
Asp Glu Gln Asn Glu Ile Ile Asp Asp Leu Ala Asn Leu Val Glu Asn 
             180                185                190
Thr Asp Glu Lys Leu Arg Thr Glu Ala Arg Arg Val Thr Leu Val Asp 
         195                200                205
Arg Lys Ser Ala Ser Cys Gly Met Ile Met Val Ile Leu Leu Leu Leu 
     210                215                220
Val Ala Ile Val Val Val Ala Val Trp Pro Thr Asn 
 225                230                235



<210> 700
<211> 824
<212> DNA
<213> Homo sapiens
<308> AF036715
<400> 700

atggccccg  acccctggt  ctccacata  gattctact  gtcaaattg  ccaagaaat  60
gctgagaaa  ttcaacaac  aaatcaata  gaaagaaaa  gtgaaaagg  accaaagct  120
accgtgaca  tcagagctt  gttgcagaa  ctgaaggaa  agatcgccc  tttgaagga  180
ttattgcta  gagctgtgt  aacacatca  ataacacag  ttgaagggg  ccgaagaca  240
aacctcttg  atgatcttg  aactcgaga  agactactt  tggcatcct  taagaatga  300
ggtgccgaa  cagatctaa  caggtccag  ctgatgagt  aagaggcta  gcgaggagc  360
cccaaccct  ggctctttg  ggagccaga  gagaccaga  gcttgggtt  tgatgaaat  420
cggcaacag  agcagaaaa  tatccaaga  caggatgca  gccttgatg  cctttcctc  480
atcataagt  gccaaaaac  aatggggca  gaaattggg  atgaattgg  tgaacaaaa  540
gagataatt  acgaccttg  caacctagt  gagaacaca  atgaaaaac  tcgcaatga  600
accaggcgg  taaacatgg  ggacagaaa  tcagcctct  gtgggatga  catggtgat  660
ttactgctg  ttgtggcta  cgtggttgt  gcagtctgg  cgaccaact  atggcagta  720
agagaccac  agcagtgac  cctgccaat  acagatgca  gcccaacac  cttttggta  780
gcaaaacct  ctctcaata  attccccca  agctcaaaa  aaaa  824



<210> 701
<211> 433
<212> PRT
<213> Homo sapiens
<308> P35998
<400> 701

Met Pro Asp Tyr Leu Gly Ala Asp Gln Arg Lys Thr Lys Glu Asp Glu 
  1               5                  10                  15
Lys Asp Asp Lys Pro Ile Arg Ala Leu Asp Glu Gly Asp Ile Ala Leu 
             20                  25                  30
Leu Lys Thr Tyr Gly Gln Ser Thr Tyr Ser Arg Gln Ile Lys Gln Val 
         35                  40                  45
Glu Asp Asp Ile Gln Gln Leu Leu Lys Lys Ile Asn Glu Leu Thr Gly 
     50                  55                  60
Ile Lys Glu Ser Asp Thr Gly Leu Ala Pro Pro Ala Leu Trp Asp Leu 
 65                  70                  75                  80
Ala Ala Asp Lys Gln Thr Leu Gln Ser Glu Gln Pro Leu Gln Val Ala 
                 85                  90                  95
Arg Cys Thr Lys Ile Ile Asn Ala Asp Ser Glu Asp Pro Lys Tyr Ile 
             100                105                110
Ile Asn Val Lys Gln Phe Ala Lys Phe Val Val Asp Leu Ser Asp Gln 
         115                120                125
Val Ala Pro Thr Asp Ile Glu Glu Gly Met Arg Val Gly Val Asp Arg 
     130                135                140
Asn Lys Tyr Gln Ile His Ile Pro Leu Pro Pro Lys Ile Asp Pro Thr 
 145                150                155                160
Val Thr Met Met Gln Val Glu Glu Lys Pro Asp Val Thr Tyr Ser Asp 
                 165                170                175
Val Gly Gly Cys Lys Glu Gln Ile Glu Lys Leu Arg Glu Val Val Glu 
             180                185                190
Thr Pro Leu Leu His Pro Glu Arg Phe Val Asn Leu Gly Ile Glu Pro 
         195                200                205
Pro Lys Gly Val Leu Leu Phe Gly Pro Pro Gly Thr Gly Lys Thr Leu 
     210                215                220
Cys Ala Arg Ala Val Ala Asn Arg Thr Asp Ala Cys Phe Ile Arg Val 
 225                230                235                240
Ile Gly Ser Glu Leu Val Gln Lys Tyr Val Gly Glu Gly Ala Arg Met 
                 245                250                255
Val Arg Glu Leu Phe Glu Met Ala Arg Thr Lys Lys Ala Cys Leu Ile 
             260                265                270
Phe Phe Asp Glu Ile Asp Ala Ile Gly Gly Ala Arg Phe Asp Asp Gly 
         275                280                285
Ala Gly Gly Asp Asn Glu Val Gln Arg Thr Met Leu Glu Leu Ile Asn 
     290                295                300
Gln Leu Asp Gly Phe Asp Pro Arg Gly Asn Ile Lys Val Leu Met Ala 
 305                310                315                320
Thr Asn Arg Pro Asp Thr Leu Asp Pro Ala Leu Met Arg Pro Gly Arg 
                 325                330                335
Leu Asp Arg Lys Ile Glu Phe Ser Leu Pro Asp Leu Glu Gly Arg Thr 
             340                345                350
His Ile Phe Lys Ile His Ala Arg Ser Met Ser Val Glu Arg Asp Ile 
         355                360                365
Arg Phe Glu Leu Leu Ala Arg Leu Cys Pro Asn Ser Thr Gly Ala Glu 
     370                375                380
Ile Arg Ser Val Cys Thr Glu Ala Gly Met Phe Ala Ile Arg Ala Arg 
 385                390                395                400
Arg Lys Ile Ala Thr Glu Lys Asp Phe Leu Glu Ala Val Asn Lys Val 
                 405                410                415
Ile Lys Ser Tyr Ala Lys Phe Ser Ala Thr Pro Arg Tyr Met Thr Tyr 
             420                425                430
Asn 
         435



<210> 702
<211> 859
<212> DNA
<213> Rattus norvegicus
<308> AF033109
<400> 702

gcacgagct  caggcggag  ctgcaccat  gccccagac  cctggttct  cacgtacga  60
tctacttgt  agattgccc  agaaatcgc  gagaagatt  aagaacgaa  tcagtgtga  120
agaagaggt  agaagacac  taagcttac  ctgacaatc  gaactttgt  gaagaatct  180
aaggtaaag  tcgacctct  gaaggactt  cttctaaga  ctgtgtcga  gcgccagat  240
acacaactg  agggggatc  aagacagaa  cttctggat  atcttgtca  ccgagagag  300
ctgctcctg  catcgttta  gaatgaggg  tccgagccg  atttgatca  gtccagcct  360
atgagtgaa  aagcaaagc  aggaactcc  aacccttgg  tctgtgagg  gccggagga  420
accagaggc  tgggtttcg  tgagatccg  caacagcag  agaaaatta  tcaagaaca  480
gacgcaggt  ttgatgccc  ttcctctat  ataagtcgc  aaaagcaaa  gggccagga  540
attgggaat  aactggacg  acagaacga  atcatcgat  accttgcca  cctggtgga  600
aacacagat  agaagcttc  cactgaagc  aggcgagtg  ccctggtgg  cagaaagtc  660
gcttcctgt  ggatgataa  ggtgatctt  ttgctgctc  tggctattg  ggtggttgc  720
gtgtggcca  ccaactgat  gcaataagg  gaccacccg  agtgacaca  ccaacaatg  780
gtgaaagcc  agcaccctt  tggtacaca  cacctcctc  caataaatt  tccacgctc  840
cggcaaaaa  aaaaaaaaa  859



<210> 703
<211> 236
<212> PRT
<213> Rattus norvegicus
<308> Q9Z2Q7
<400> 703

Met Ala Pro Asp Pro Trp Phe Ser Thr Tyr Asp Ser Thr Cys Gln Ile 
  1               5                  10                  15
Ala Gln Glu Ile Ala Glu Lys Ile Gln Glu Arg Asn Gln Cys Glu Arg 
             20                  25                  30
Arg Gly Glu Lys Thr Pro Lys Leu Thr Leu Thr Ile Arg Thr Leu Leu 
         35                  40                  45
Lys Asn Leu Lys Val Lys Ile Asp Leu Leu Lys Asp Leu Leu Leu Arg 
     50                  55                  60
Ala Val Ser Thr Arg Gln Ile Thr Gln Leu Glu Gly Asp Arg Arg Gln 
 65                  70                  75                  80
Asn Leu Leu Asp Asp Leu Val Thr Arg Glu Arg Leu Leu Leu Ala Ser 
                 85                  90                  95
Phe Lys Asn Glu Gly Ser Glu Pro Asp Leu Ile Arg Ser Ser Leu Met 
             100                105                110
Ser Glu Glu Ala Lys Arg Gly Thr Pro Asn Pro Trp Leu Cys Glu Glu 
         115                120                125
Pro Glu Glu Thr Arg Gly Leu Gly Phe Asp Glu Ile Arg Gln Gln Gln 
     130                135                140
Gln Lys Ile Ile Gln Glu Gln Asp Ala Gly Leu Asp Ala Leu Ser Ser 
 145                150                155                160
Ile Ile Ser Arg Gln Lys Gln Met Gly Gln Glu Ile Gly Asn Glu Leu 
                 165                170                175
Asp Glu Gln Asn Glu Ile Ile Asp Asp Leu Ala Asn Leu Val Glu Asn 
             180                185                190
Thr Asp Glu Lys Leu Arg Thr Glu Ala Arg Arg Val Thr Leu Val Asp 
         195                200                205
Arg Lys Ser Ala Ser Cys Gly Met Ile Met Val Ile Leu Leu Leu Leu 
     210                215                220
Val Ala Ile Val Val Val Ala Val Trp Pro Thr Asn 
 225                230                235



<210> 704
<211> 824
<212> DNA
<213> Homo sapiens
<308> AF036715
<400> 704

atggccccg  acccctggt  ctccacata  gattctact  gtcaaattg  ccaagaaat  60
gctgagaaa  ttcaacaac  aaatcaata  gaaagaaaa  gtgaaaagg  accaaagct  120
accgtgaca  tcagagctt  gttgcagaa  ctgaaggaa  agatcgccc  tttgaagga  180
ttattgcta  gagctgtgt  aacacatca  ataacacag  ttgaagggg  ccgaagaca  240
aacctcttg  atgatcttg  aactcgaga  agactactt  tggcatcct  taagaatga  300
ggtgccgaa  cagatctaa  caggtccag  ctgatgagt  aagaggcta  gcgaggagc  360
cccaaccct  ggctctttg  ggagccaga  gagaccaga  gcttgggtt  tgatgaaat  420
cggcaacag  agcagaaaa  tatccaaga  caggatgca  gccttgatg  cctttcctc  480
atcataagt  gccaaaaac  aatggggca  gaaattggg  atgaattgg  tgaacaaaa  540
gagataatt  acgaccttg  caacctagt  gagaacaca  atgaaaaac  tcgcaatga  600
accaggcgg  taaacatgg  ggacagaaa  tcagcctct  gtgggatga  catggtgat  660
ttactgctg  ttgtggcta  cgtggttgt  gcagtctgg  cgaccaact  atggcagta  720
agagaccac  agcagtgac  cctgccaat  acagatgca  gcccaacac  cttttggta  780
gcaaaacct  ctctcaata  attccccca  agctcaaaa  aaaa  824



<210> 705
<211> 433
<212> PRT
<213> Homo sapiens
<308> P35998
<400> 705

Met Pro Asp Tyr Leu Gly Ala Asp Gln Arg Lys Thr Lys Glu Asp Glu 
  1               5                  10                  15
Lys Asp Asp Lys Pro Ile Arg Ala Leu Asp Glu Gly Asp Ile Ala Leu 
             20                  25                  30
Leu Lys Thr Tyr Gly Gln Ser Thr Tyr Ser Arg Gln Ile Lys Gln Val 
         35                  40                  45
Glu Asp Asp Ile Gln Gln Leu Leu Lys Lys Ile Asn Glu Leu Thr Gly 
     50                  55                  60
Ile Lys Glu Ser Asp Thr Gly Leu Ala Pro Pro Ala Leu Trp Asp Leu 
 65                  70                  75                  80
Ala Ala Asp Lys Gln Thr Leu Gln Ser Glu Gln Pro Leu Gln Val Ala 
                 85                  90                  95
Arg Cys Thr Lys Ile Ile Asn Ala Asp Ser Glu Asp Pro Lys Tyr Ile 
             100                105                110
Ile Asn Val Lys Gln Phe Ala Lys Phe Val Val Asp Leu Ser Asp Gln 
         115                120                125
Val Ala Pro Thr Asp Ile Glu Glu Gly Met Arg Val Gly Val Asp Arg 
     130                135                140
Asn Lys Tyr Gln Ile His Ile Pro Leu Pro Pro Lys Ile Asp Pro Thr 
 145                150                155                160
Val Thr Met Met Gln Val Glu Glu Lys Pro Asp Val Thr Tyr Ser Asp 
                 165                170                175
Val Gly Gly Cys Lys Glu Gln Ile Glu Lys Leu Arg Glu Val Val Glu 
             180                185                190
Thr Pro Leu Leu His Pro Glu Arg Phe Val Asn Leu Gly Ile Glu Pro 
         195                200                205
Pro Lys Gly Val Leu Leu Phe Gly Pro Pro Gly Thr Gly Lys Thr Leu 
     210                215                220
Cys Ala Arg Ala Val Ala Asn Arg Thr Asp Ala Cys Phe Ile Arg Val 
 225                230                235                240
Ile Gly Ser Glu Leu Val Gln Lys Tyr Val Gly Glu Gly Ala Arg Met 
                 245                250                255
Val Arg Glu Leu Phe Glu Met Ala Arg Thr Lys Lys Ala Cys Leu Ile 
             260                265                270
Phe Phe Asp Glu Ile Asp Ala Ile Gly Gly Ala Arg Phe Asp Asp Gly 
         275                280                285
Ala Gly Gly Asp Asn Glu Val Gln Arg Thr Met Leu Glu Leu Ile Asn 
     290                295                300
Gln Leu Asp Gly Phe Asp Pro Arg Gly Asn Ile Lys Val Leu Met Ala 
 305                310                315                320
Thr Asn Arg Pro Asp Thr Leu Asp Pro Ala Leu Met Arg Pro Gly Arg 
                 325                330                335
Leu Asp Arg Lys Ile Glu Phe Ser Leu Pro Asp Leu Glu Gly Arg Thr 
             340                345                350
His Ile Phe Lys Ile His Ala Arg Ser Met Ser Val Glu Arg Asp Ile 
         355                360                365
Arg Phe Glu Leu Leu Ala Arg Leu Cys Pro Asn Ser Thr Gly Ala Glu 
     370                375                380
Ile Arg Ser Val Cys Thr Glu Ala Gly Met Phe Ala Ile Arg Ala Arg 
 385                390                395                400
Arg Lys Ile Ala Thr Glu Lys Asp Phe Leu Glu Ala Val Asn Lys Val 
                 405                410                415
Ile Lys Ser Tyr Ala Lys Phe Ser Ala Thr Pro Arg Tyr Met Thr Tyr 
             420                425                430
Asn 
         435



<210> 706
<211> 1892
<212> DNA
<213> Rattus norvegicus
<308> AF034218
<400> 706

cgggcgggc  tagctggta  caggatggc  gcggccctg  cgtgggtcc  ggcggcgcc  60
ggtgcgagt  cctgagctg  taccaggca  gtgacactt  ctgtagccc  cagcatgcg  120
gcaggactg  gtcccatca  cacactggc  ctagtgctg  aggtagcat  ggcctcgga  180
cttaagccc  cagcgccgc  catcttcac  ggccgaccc  ttgtggtag  atggaatgt  240
cccacacaa  aatgtgctc  gcgccacaa  gtgcccctg  accttaggg  cttcgatgt  300
gaggctaca  ctaacgagg  ttttttcaa  cagaatatc  ccaccttct  ctatgaccg  360
ctaggcctg  atccacgtt  tgatgcagc  gggatgtct  tgcatggtg  cgtgcctca  420
aacggtagc  tctgtgcac  cctgcccat  ctgaaggaa  ctgtggaac  ctacattca  480
acccaagag  ctgcggggc  ggcggtcat  gactgggag  aatggcgac  agtgtgggt  540
cgaaactgg  aggagaaag  tgtgtaccg  cagtcttca  gccagctgg  ggccagtcg  600
caccctgac  ggccatcag  ccgaatagt  aagcaggcg  agtacgaat  cgagttcgc  660
gctcggcag  tcatgttga  cacactccg  tacgtcaag  cagtcagac  tcagcacct  720
tggggcttc  acctctttc  tgactgcta  aatcatgat  acgtacaga  ctgggatag  780
tacacaggc  gctgtcctg  cgtggaggt  gcacaaaat  accagttgg  ctggctctg  840
gctgaaaat  cagctctct  tccctccgt  tacctggac  agacgctgg  atcctccaa  900
cacagccgc  actttgtca  cttccgtgt  caggaagcc  ttcgtgtgg  tcacaccca  960
catgcaaac  atgcactcc  cgtgtatgt  ttcacgcgt  ccacatata  ccgaaggct  1020
acagaactt  accagatgg  cctcatctc  accatcggt  aaagcgccg  cctgggctc  1080
gctggtgtt  tcttctggg  cgactcagt  tacgcttca  gtatggaaa  ctgccagaa  1140
ctcaagaag  acctaacgc  gacgctggt  ccctacata  tcaatgtgt  ctgggccac  1200
cagtactgc  gttggaccc  gtgccatgg  catgggcgc  gtgtgcgcc  caatcccag  1260
gccagtacc  tcttgcacc  cagtcccag  agcttccgc  tggtgcctg  ccgcacgcc  1320
agtgaaccc  agcttcgac  tgaggggga  ctcagcgaa  atgacctca  ctacctgca  1380
atgcacttt  gctgccact  ctatctggg  tggggtggt  agcagtgcc  gtggaacca  1440
aaacgggca  ctggggatg  cagtagagc  tgggctgga  cccacctcg  cagtctcct  1500
ggtttggta  ctatgactc  cacctggac  ttataaggg  tctctcccc  cagatagca  1560
tccagctgg  ctctggcac  aggatctcc  tggcacaag  agcctgtta  ggggtaggc  1620
aatgagtct  gagttggag  gggcagtac  cccaggatg  ctagaagag  atccatacc  1680
cctgtcacc  ccctgttct  agggggaga  aaacatccc  tgagatgcc  tcatcttgc  1740
agagaagac  aggatacag  taggccggg  aaggcctac  tctactctc  gttcctgga  1800
agtttataa  cttggggtc  cttttgtaa  ttaaataca  aacaactgc  aaaaaaaaa  1860
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aa  1892



<210> 707
<211> 473
<212> PRT
<213> Rattus norvegicus
<308> AAD01980
<400> 707

Met Arg Ala Gly Leu Gly Pro Ile Ile Thr Leu Ala Leu Val Leu Glu 
  1               5                  10                  15
Val Ala Trp Ala Ser Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
             20                  25                  30
Gly Arg Pro Phe Val Val Ala Trp Asn Val Pro Thr Gln Glu Cys Ala 
         35                  40                  45
Pro Arg His Lys Val Pro Leu Asp Leu Arg Ala Phe Asp Val Glu Ala 
     50                  55                  60
Thr Pro Asn Glu Gly Phe Phe Asn Gln Asn Ile Thr Thr Phe Tyr Tyr 
 65                  70                  75                  80
Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ala Ala Gly Met Ser Val 
                 85                  90                  95
His Gly Gly Val Pro Gln Asn Gly Ser Leu Cys Ala His Leu Pro Met 
             100                105                110
Leu Lys Glu Ala Val Glu Arg Tyr Ile Gln Thr Gln Glu Pro Ala Gly 
         115                120                125
Leu Ala Val Ile Asp Trp Glu Glu Trp Arg Pro Val Trp Val Arg Asn 
     130                135                140
Trp Gln Glu Lys Asp Val Tyr Arg Gln Ser Ser Arg Gln Leu Val Ala 
 145                150                155                160
Ser Arg His Pro Asp Trp Pro Ser Asp Arg Ile Val Lys Gln Ala Gln 
                 165                170                175
Tyr Glu Phe Glu Phe Ala Ala Arg Gln Phe Met Leu Asn Thr Leu Arg 
             180                185                190
Tyr Val Lys Ala Val Arg Pro Gln His Leu Trp Gly Phe Tyr Leu Phe 
         195                200                205
Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Asp Ser Tyr Thr 
     210                215                220
Gly Arg Cys Pro Asp Val Glu Val Ala Gln Asn Asp Gln Leu Ala Trp 
 225                230                235                240
Leu Trp Ala Glu Asn Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Lys 
                 245                250                255
Thr Leu Ala Ser Ser Lys His Ser Arg Asn Phe Val Ser Phe Arg Val 
             260                265                270
Gln Glu Ala Leu Arg Val Ala His Thr His His Ala Asn His Ala Leu 
         275                280                285
Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Thr Arg Arg Leu Thr Glu 
     290                295                300
Leu Asn Gln Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu 
 305                310                315                320
Gly Ser Ala Gly Val Ile Phe Trp Gly Asp Ser Val Tyr Ala Ser Ser 
                 325                330                335
Met Glu Asn Cys Gln Asn Leu Lys Lys Tyr Leu Thr Gln Thr Leu Val 
             340                345                350
Pro Tyr Ile Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Trp Thr 
         355                360                365
Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser 
     370                375                380
Thr Phe Leu His Leu Ser Pro Ser Ser Phe Arg Leu Val Pro Gly Arg 
 385                390                395                400
Thr Pro Ser Glu Pro Gln Leu Arg Pro Glu Gly Glu Leu Ser Glu Asp 
                 405                410                415
Asp Leu Ser Tyr Leu Gln Met His Phe Arg Cys His Cys Tyr Leu Gly 
             420                425                430
Trp Gly Gly Glu Gln Cys Gln Trp Asn His Lys Arg Ala Ala Gly Asp 
         435                440                445
Ala Ser Arg Ala Trp Ala Gly Ala His Leu Ala Ser Leu Leu Gly Leu 
     450                455                460
Val Ala Met Thr Leu Thr Trp Thr Leu 
 465                470



<210> 708
<211> 1918
<212> DNA
<213> Homo sapiens
<308> BC000692
<400> 708

ggcacgagg  ggcgctgag  cgggccgcg  ctgggcgaa  ggccggagc  ggctgggct  60
ggcccggga  ggcggtggc  ctggcgccg  tcccggtgg  gccccgcgc  agttcctga  120
ctggtgcca  gcaggtgac  cctcctgca  cccccagca  gcgggcagg  ccaggcccc  180
ccgttacat  ggccctggt  ctggcggtg  catgggcca  ggagctcaa  cccacagca  240
cacccatct  cactggccg  ccctttgtg  tagcgtggg  cgtgcccac  caggactgt  300
gcccacgcc  caaggtgcc  ctggacctg  atgcctttg  tgtgcaggc  tcacctaat  360
agggttttg  gaaccagaa  attaccatc  tctaccgcg  ccgtctagg  ctgtatcca  420
gcttcgatt  tgccggaag  tctgtgcat  gtggtgtgc  acagaatgt  agcctttgg  480
cacaccgga  gatgctgca  aaacgtgtg  agcactaca  tcggacaca  gagtctgcg  540
ggctggcgg  catcgactg  gaggactgg  gacctgtgt  ggtgcgcaa  tggcaggac  600
aagatgtgt  tcgccggtt  tcacgccag  tagtggcca  tcgtcaccc  gactggcct  660
cagaccgca  agtcaaaca  gcacaatat  agtttgagt  cgcagcaca  cagttcatg  720
tggagacac  gcgttatgt  aaggcagtg  ggccccggc  cctctgggg  ttctacctc  780
ttcctgact  ctacaatca  gattatgtg  agaactggg  gagctacac  ggccgctgc  840
ctgatgttg  ggtggcccg  aatgaccag  tggcctggc  gtgggctga  agcacggcc  900
tcttcccgt  tgtctacct  gacgagaca  ttgcttcct  ccgccatgg  cgcaacttt  960
tgagcttcc  tgttcagga  gcccttcgt  tggctcgca  ccaccatgc  aaccatgca  1020
tcccagtct  cgtcttcac  cgacccacc  acagccgca  gctcacggg  cttagtgag  1080
tggacctca  ctctaccat  ggcgagagt  cggccctgg  cgcagctgg  gtcatcctc  1140
ggggtgacg  ggggtacac  acaagcacg  agacctgcc  gtacctcaa  gattacctg  1200
cacggctgc  ggtccccta  gtggtcaat  tgtcctggg  cacccaata  tgcagccgg  1260
cccagtgcc  tggccatgg  cgctgtgtg  gccgcaacc  cagtgccag  accttcctg  1320
atctcagca  caacagttt  cgcctagtg  ctggccatg  acctggtga  ccccagctg  1380
gacctgtgg  ggagctcag  tgggccgac  ttgaccacc  gcagacaca  ttccgctgc  1440
agtgctact  gggctggag  ggtgagcaa  gccagtggg  ccataggca  gcagctgga  1500
gtgccagcg  ggcctgggc  gggtcccac  tcaccagtc  gctggctct  gcagccctg  1560
cctttacct  gaccttgta  gggtctcct  cctagctgc  tagcaagct  gcctctacc  1620
caagggctc  cttaggcat  taggaccct  cagggggtg  acaaactgg  gtctggagt  1680
ggcagagcc  ccaggaagc  caggagggc  tccatacca  ctcgcaccc  cctgttcta  1740
gggggaggg  aagtccctg  gaggcccct  ctctccctg  cagagggga  ggagggtac  1800
gctgggctg  ggaggacct  accctactc  cttgcccta  atagtttat  attattatt  1860
ttttggggt  tcttttgta  attaaacat  aaacaattg  aaaaaaaaa  aaaaaaaa  1918



<210> 709
<211> 473
<212> PRT
<213> Homo sapiens
<308> NP_149348
<400> 709

Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
  1               5                  10                  15
Val Ala Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
             20                  25                  30
Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
         35                  40                  45
Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala 
     50                  55                  60
Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg 
 65                  70                  75                  80
Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ser Ala Gly Arg Ser Val 
                 85                  90                  95
His Gly Gly Val Pro Gln Asn Val Ser Leu Trp Ala His Arg Lys Met 
             100                105                110
Leu Gln Lys Arg Val Glu His Tyr Ile Arg Thr Gln Glu Ser Ala Gly 
         115                120                125
Leu Ala Val Ile Asp Trp Glu Asp Trp Arg Pro Val Trp Val Arg Asn 
     130                135                140
Trp Gln Asp Lys Asp Val Tyr Arg Arg Leu Ser Arg Gln Leu Val Ala 
 145                150                155                160
Ser Arg His Pro Asp Trp Pro Pro Asp Arg Ile Val Lys Gln Ala Gln 
                 165                170                175
Tyr Glu Phe Glu Phe Ala Ala Gln Gln Phe Met Leu Glu Thr Leu Arg 
             180                185                190
Tyr Val Lys Ala Val Arg Pro Arg His Leu Trp Gly Phe Tyr Leu Phe 
         195                200                205
Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Glu Ser Tyr Thr 
     210                215                220
Gly Arg Cys Pro Asp Val Glu Val Ala Arg Asn Asp Gln Leu Ala Trp 
 225                230                235                240
Leu Trp Ala Glu Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Glu 
                 245                250                255
Thr Leu Ala Ser Ser Arg His Gly Arg Asn Phe Val Ser Phe Arg Val 
             260                265                270
Gln Glu Ala Leu Arg Val Ala Arg Thr His His Ala Asn His Ala Leu 
         275                280                285
Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Ser Arg Arg Leu Thr Gly 
     290                295                300
Leu Ser Glu Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu 
 305                310                315                320
Gly Ala Ala Gly Val Ile Leu Trp Gly Asp Ala Gly Tyr Thr Thr Ser 
                 325                330                335
Thr Glu Thr Cys Gln Tyr Leu Lys Asp Tyr Leu Thr Arg Leu Leu Val 
             340                345                350
Pro Tyr Val Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Arg Ala 
         355                360                365
Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser 
     370                375                380
Thr Phe Leu His Leu Ser Thr Asn Ser Phe Arg Leu Val Pro Gly His 
 385                390                395                400
Ala Pro Gly Glu Pro Gln Leu Arg Pro Val Gly Glu Leu Ser Trp Ala 
                 405                410                415
Asp Ile Asp His Leu Gln Thr His Phe Arg Cys Gln Cys Tyr Leu Gly 
             420                425                430
Trp Ser Gly Glu Gln Cys Gln Trp Asp His Arg Gln Ala Ala Gly Gly 
         435                440                445
Ala Ser Glu Ala Trp Ala Gly Ser His Leu Thr Ser Leu Leu Ala Leu 
     450                455                460
Ala Ala Leu Ala Phe Thr Trp Thr Leu 
 465                470



<210> 710
<211> 1892
<212> DNA
<213> Rattus norvegicus
<308> AF034218
<400> 710

cgggcgggc  tagctggta  caggatggc  gcggccctg  cgtgggtcc  ggcggcgcc  60
ggtgcgagt  cctgagctg  taccaggca  gtgacactt  ctgtagccc  cagcatgcg  120
gcaggactg  gtcccatca  cacactggc  ctagtgctg  aggtagcat  ggcctcgga  180
cttaagccc  cagcgccgc  catcttcac  ggccgaccc  ttgtggtag  atggaatgt  240
cccacacaa  aatgtgctc  gcgccacaa  gtgcccctg  accttaggg  cttcgatgt  300
gaggctaca  ctaacgagg  ttttttcaa  cagaatatc  ccaccttct  ctatgaccg  360
ctaggcctg  atccacgtt  tgatgcagc  gggatgtct  tgcatggtg  cgtgcctca  420
aacggtagc  tctgtgcac  cctgcccat  ctgaaggaa  ctgtggaac  ctacattca  480
acccaagag  ctgcggggc  ggcggtcat  gactgggag  aatggcgac  agtgtgggt  540
cgaaactgg  aggagaaag  tgtgtaccg  cagtcttca  gccagctgg  ggccagtcg  600
caccctgac  ggccatcag  ccgaatagt  aagcaggcg  agtacgaat  cgagttcgc  660
gctcggcag  tcatgttga  cacactccg  tacgtcaag  cagtcagac  tcagcacct  720
tggggcttc  acctctttc  tgactgcta  aatcatgat  acgtacaga  ctgggatag  780
tacacaggc  gctgtcctg  cgtggaggt  gcacaaaat  accagttgg  ctggctctg  840
gctgaaaat  cagctctct  tccctccgt  tacctggac  agacgctgg  atcctccaa  900
cacagccgc  actttgtca  cttccgtgt  caggaagcc  ttcgtgtgg  tcacaccca  960
catgcaaac  atgcactcc  cgtgtatgt  ttcacgcgt  ccacatata  ccgaaggct  1020
acagaactt  accagatgg  cctcatctc  accatcggt  aaagcgccg  cctgggctc  1080
gctggtgtt  tcttctggg  cgactcagt  tacgcttca  gtatggaaa  ctgccagaa  1140
ctcaagaag  acctaacgc  gacgctggt  ccctacata  tcaatgtgt  ctgggccac  1200
cagtactgc  gttggaccc  gtgccatgg  catgggcgc  gtgtgcgcc  caatcccag  1260
gccagtacc  tcttgcacc  cagtcccag  agcttccgc  tggtgcctg  ccgcacgcc  1320
agtgaaccc  agcttcgac  tgaggggga  ctcagcgaa  atgacctca  ctacctgca  1380
atgcacttt  gctgccact  ctatctggg  tggggtggt  agcagtgcc  gtggaacca  1440
aaacgggca  ctggggatg  cagtagagc  tgggctgga  cccacctcg  cagtctcct  1500
ggtttggta  ctatgactc  cacctggac  ttataaggg  tctctcccc  cagatagca  1560
tccagctgg  ctctggcac  aggatctcc  tggcacaag  agcctgtta  ggggtaggc  1620
aatgagtct  gagttggag  gggcagtac  cccaggatg  ctagaagag  atccatacc  1680
cctgtcacc  ccctgttct  agggggaga  aaacatccc  tgagatgcc  tcatcttgc  1740
agagaagac  aggatacag  taggccggg  aaggcctac  tctactctc  gttcctgga  1800
agtttataa  cttggggtc  cttttgtaa  ttaaataca  aacaactgc  aaaaaaaaa  1860
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aa  1892



<210> 711
<211> 473
<212> PRT
<213> Rattus norvegicus
<308> AAD01980
<400> 711

Met Arg Ala Gly Leu Gly Pro Ile Ile Thr Leu Ala Leu Val Leu Glu 
  1               5                  10                  15
Val Ala Trp Ala Ser Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
             20                  25                  30
Gly Arg Pro Phe Val Val Ala Trp Asn Val Pro Thr Gln Glu Cys Ala 
         35                  40                  45
Pro Arg His Lys Val Pro Leu Asp Leu Arg Ala Phe Asp Val Glu Ala 
     50                  55                  60
Thr Pro Asn Glu Gly Phe Phe Asn Gln Asn Ile Thr Thr Phe Tyr Tyr 
 65                  70                  75                  80
Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ala Ala Gly Met Ser Val 
                 85                  90                  95
His Gly Gly Val Pro Gln Asn Gly Ser Leu Cys Ala His Leu Pro Met 
             100                105                110
Leu Lys Glu Ala Val Glu Arg Tyr Ile Gln Thr Gln Glu Pro Ala Gly 
         115                120                125
Leu Ala Val Ile Asp Trp Glu Glu Trp Arg Pro Val Trp Val Arg Asn 
     130                135                140
Trp Gln Glu Lys Asp Val Tyr Arg Gln Ser Ser Arg Gln Leu Val Ala 
 145                150                155                160
Ser Arg His Pro Asp Trp Pro Ser Asp Arg Ile Val Lys Gln Ala Gln 
                 165                170                175
Tyr Glu Phe Glu Phe Ala Ala Arg Gln Phe Met Leu Asn Thr Leu Arg 
             180                185                190
Tyr Val Lys Ala Val Arg Pro Gln His Leu Trp Gly Phe Tyr Leu Phe 
         195                200                205
Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Asp Ser Tyr Thr 
     210                215                220
Gly Arg Cys Pro Asp Val Glu Val Ala Gln Asn Asp Gln Leu Ala Trp 
 225                230                235                240
Leu Trp Ala Glu Asn Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Lys 
                 245                250                255
Thr Leu Ala Ser Ser Lys His Ser Arg Asn Phe Val Ser Phe Arg Val 
             260                265                270
Gln Glu Ala Leu Arg Val Ala His Thr His His Ala Asn His Ala Leu 
         275                280                285
Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Thr Arg Arg Leu Thr Glu 
     290                295                300
Leu Asn Gln Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu 
 305                310                315                320
Gly Ser Ala Gly Val Ile Phe Trp Gly Asp Ser Val Tyr Ala Ser Ser 
                 325                330                335
Met Glu Asn Cys Gln Asn Leu Lys Lys Tyr Leu Thr Gln Thr Leu Val 
             340                345                350
Pro Tyr Ile Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Trp Thr 
         355                360                365
Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser 
     370                375                380
Thr Phe Leu His Leu Ser Pro Ser Ser Phe Arg Leu Val Pro Gly Arg 
 385                390                395                400
Thr Pro Ser Glu Pro Gln Leu Arg Pro Glu Gly Glu Leu Ser Glu Asp 
                 405                410                415
Asp Leu Ser Tyr Leu Gln Met His Phe Arg Cys His Cys Tyr Leu Gly 
             420                425                430
Trp Gly Gly Glu Gln Cys Gln Trp Asn His Lys Arg Ala Ala Gly Asp 
         435                440                445
Ala Ser Arg Ala Trp Ala Gly Ala His Leu Ala Ser Leu Leu Gly Leu 
     450                455                460
Val Ala Met Thr Leu Thr Trp Thr Leu 
 465                470



<210> 712
<211> 1918
<212> DNA
<213> Homo sapiens
<308> BC000692
<400> 712

ggcacgagg  ggcgctgag  cgggccgcg  ctgggcgaa  ggccggagc  ggctgggct  60
ggcccggga  ggcggtggc  ctggcgccg  tcccggtgg  gccccgcgc  agttcctga  120
ctggtgcca  gcaggtgac  cctcctgca  cccccagca  gcgggcagg  ccaggcccc  180
ccgttacat  ggccctggt  ctggcggtg  catgggcca  ggagctcaa  cccacagca  240
cacccatct  cactggccg  ccctttgtg  tagcgtggg  cgtgcccac  caggactgt  300
gcccacgcc  caaggtgcc  ctggacctg  atgcctttg  tgtgcaggc  tcacctaat  360
agggttttg  gaaccagaa  attaccatc  tctaccgcg  ccgtctagg  ctgtatcca  420
gcttcgatt  tgccggaag  tctgtgcat  gtggtgtgc  acagaatgt  agcctttgg  480
cacaccgga  gatgctgca  aaacgtgtg  agcactaca  tcggacaca  gagtctgcg  540
ggctggcgg  catcgactg  gaggactgg  gacctgtgt  ggtgcgcaa  tggcaggac  600
aagatgtgt  tcgccggtt  tcacgccag  tagtggcca  tcgtcaccc  gactggcct  660
cagaccgca  agtcaaaca  gcacaatat  agtttgagt  cgcagcaca  cagttcatg  720
tggagacac  gcgttatgt  aaggcagtg  ggccccggc  cctctgggg  ttctacctc  780
ttcctgact  ctacaatca  gattatgtg  agaactggg  gagctacac  ggccgctgc  840
ctgatgttg  ggtggcccg  aatgaccag  tggcctggc  gtgggctga  agcacggcc  900
tcttcccgt  tgtctacct  gacgagaca  ttgcttcct  ccgccatgg  cgcaacttt  960
tgagcttcc  tgttcagga  gcccttcgt  tggctcgca  ccaccatgc  aaccatgca  1020
tcccagtct  cgtcttcac  cgacccacc  acagccgca  gctcacggg  cttagtgag  1080
tggacctca  ctctaccat  ggcgagagt  cggccctgg  cgcagctgg  gtcatcctc  1140
ggggtgacg  ggggtacac  acaagcacg  agacctgcc  gtacctcaa  gattacctg  1200
cacggctgc  ggtccccta  gtggtcaat  tgtcctggg  cacccaata  tgcagccgg  1260
cccagtgcc  tggccatgg  cgctgtgtg  gccgcaacc  cagtgccag  accttcctg  1320
atctcagca  caacagttt  cgcctagtg  ctggccatg  acctggtga  ccccagctg  1380
gacctgtgg  ggagctcag  tgggccgac  ttgaccacc  gcagacaca  ttccgctgc  1440
agtgctact  gggctggag  ggtgagcaa  gccagtggg  ccataggca  gcagctgga  1500
gtgccagcg  ggcctgggc  gggtcccac  tcaccagtc  gctggctct  gcagccctg  1560
cctttacct  gaccttgta  gggtctcct  cctagctgc  tagcaagct  gcctctacc  1620
caagggctc  cttaggcat  taggaccct  cagggggtg  acaaactgg  gtctggagt  1680
ggcagagcc  ccaggaagc  caggagggc  tccatacca  ctcgcaccc  cctgttcta  1740
gggggaggg  aagtccctg  gaggcccct  ctctccctg  cagagggga  ggagggtac  1800
gctgggctg  ggaggacct  accctactc  cttgcccta  atagtttat  attattatt  1860
ttttggggt  tcttttgta  attaaacat  aaacaattg  aaaaaaaaa  aaaaaaaa  1918



<210> 713
<211> 473
<212> PRT
<213> Homo sapiens
<308> NP_149348
<400> 713

Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
  1               5                  10                  15
Val Ala Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
             20                  25                  30
Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
         35                  40                  45
Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala 
     50                  55                  60
Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg 
 65                  70                  75                  80
Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ser Ala Gly Arg Ser Val 
                 85                  90                  95
His Gly Gly Val Pro Gln Asn Val Ser Leu Trp Ala His Arg Lys Met 
             100                105                110
Leu Gln Lys Arg Val Glu His Tyr Ile Arg Thr Gln Glu Ser Ala Gly 
         115                120                125
Leu Ala Val Ile Asp Trp Glu Asp Trp Arg Pro Val Trp Val Arg Asn 
     130                135                140
Trp Gln Asp Lys Asp Val Tyr Arg Arg Leu Ser Arg Gln Leu Val Ala 
 145                150                155                160
Ser Arg His Pro Asp Trp Pro Pro Asp Arg Ile Val Lys Gln Ala Gln 
                 165                170                175
Tyr Glu Phe Glu Phe Ala Ala Gln Gln Phe Met Leu Glu Thr Leu Arg 
             180                185                190
Tyr Val Lys Ala Val Arg Pro Arg His Leu Trp Gly Phe Tyr Leu Phe 
         195                200                205
Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Glu Ser Tyr Thr 
     210                215                220
Gly Arg Cys Pro Asp Val Glu Val Ala Arg Asn Asp Gln Leu Ala Trp 
 225                230                235                240
Leu Trp Ala Glu Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Glu 
                 245                250                255
Thr Leu Ala Ser Ser Arg His Gly Arg Asn Phe Val Ser Phe Arg Val 
             260                265                270
Gln Glu Ala Leu Arg Val Ala Arg Thr His His Ala Asn His Ala Leu 
         275                280                285
Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Ser Arg Arg Leu Thr Gly 
     290                295                300
Leu Ser Glu Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu 
 305                310                315                320
Gly Ala Ala Gly Val Ile Leu Trp Gly Asp Ala Gly Tyr Thr Thr Ser 
                 325                330                335
Thr Glu Thr Cys Gln Tyr Leu Lys Asp Tyr Leu Thr Arg Leu Leu Val 
             340                345                350
Pro Tyr Val Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Arg Ala 
         355                360                365
Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser 
     370                375                380
Thr Phe Leu His Leu Ser Thr Asn Ser Phe Arg Leu Val Pro Gly His 
 385                390                395                400
Ala Pro Gly Glu Pro Gln Leu Arg Pro Val Gly Glu Leu Ser Trp Ala 
                 405                410                415
Asp Ile Asp His Leu Gln Thr His Phe Arg Cys Gln Cys Tyr Leu Gly 
             420                425                430
Trp Ser Gly Glu Gln Cys Gln Trp Asp His Arg Gln Ala Ala Gly Gly 
         435                440                445
Ala Ser Glu Ala Trp Ala Gly Ser His Leu Thr Ser Leu Leu Ala Leu 
     450                455                460
Ala Ala Leu Ala Phe Thr Trp Thr Leu 
 465                470



<210> 714
<211> 4422
<212> DNA
<213> Rattus norvegicus
<308> AF034582
<400> 714

gatcctggg  gagtccgac  ttcgccggc  aacgcagga  aggtcactg  ggtccgcca  60
gtgtgtccg  cgtttgttt  ctgcccctc  ccaggttcg  tgtccgctg  cgaggcccg  120
ggcccttct  ccgctgtcg  cgcgccccc  tgtctcgtt  cggccccgc  gggacaacg  180
ctggagtcg  agcagccgg  tgatcgcgc  cgtcatcct  taccaacgt  tccaggctg  240
cctgctcgg  agtgggtga  aatgaagct  aaggagata  accgcacag  gatgcaggc  300
tggagccct  cccagaacc  ccccattta  ctggccaca  ggacatctg  tcagcagtt  360
gacgcgaca  tcagtacca  cgcttccct  gagatattc  agctcgacc  ttccgaccc  420
tccttggat  tgaagtcct  tgctacttt  tcctcgtct  acaggtacc  caagttgat  480
tggggacct  ataaaatgg  ttccaaagg  gatgtttct  gagttttga  tgcaggtgg  540
gaaaatgga  acattattc  ctacgatcc  tctaaaatt  tagctggag  caaggaagt  600
gtgattgcc  aaaaggaca  gcatactgg  ccagtgaga  ccttggatg  aaacatctt  660
cagaccaat  tggtggcct  tggtgctaa  gaatctgaa  tctacattt  ggatctaaa  720
aattttgca  ctccaatga  gccaggagc  aaaacacag  caccagaag  tatcagctg  780
atagcctgg  acagacagg  ccagcatat  ttagcatca  ccagtccca  tggccgggc  840
acggtctgg  atctcagga  aaacgagcc  attatcaaa  tcagcaacc  cagtaactg  900
atgcactgc  ctgggctgg  atggcaccc  gatgtcgct  ctcagatgg  ccttgcttc  960
gaggatgat  gattaccag  ggtccagat  tgggatctt  gatttgctt  ctctcccct  1020
cgggttctg  aaaatcatg  cagggggat  ttggcaatt  cttggagca  ggcagatcc  1080
gaattgttg  taagctgtg  aaaagatgc  aagattctc  gctctaacc  taacacggg  1140
gaggtatta  atgaacttc  caccaacac  cagtggtgc  ttgatatcc  gtggtgtcc  1200
cggaatcct  ccgtcctgt  tgccgcttc  ttcgatggt  gcatccgtg  ctactccat  1260
atgggaggg  gcatagacg  cttaaggca  aaacaagtt  acaagcttt  gtcgtcttt  1320
gggaatctt  atccgtttg  cacaggaca  ccgctccct  cattacaaa  cccacagca  1380
acttcacag  acagcatcg  gctgcccct  aagaagccg  ccaagtgga  ccggagacc  1440
gtgggcgcc  ccttctcat  cggagggaa  ttggtgact  tcgagaacg  tacagggca  1500
cctcagcag  gagctgagc  gccacggcg  cagcccgtg  tcatcagtc  ggtggtgac  1560
gaaaaggac  tcctcagcc  ctcagagca  ctacagcac  tcgtcgagt  tcagggctt  1620
atcagttac  gccagaaaa  gatcgatgc  tcccagact  acttcgaga  gaatgtgtg  1680
tccttcttg  aggtaaagt  tgaggagga  tctcgtggg  aataccttg  gcttcttgg  1740
tatagaaga  aagatctgg  agagaagat  gctttggcc  tgaacagag  ggacggatc  1800
gatgtggct  ttaaggact  tgaccgcgt  gcgcagagt  atggggagg  gagccctgc  1860
gaggaaggg  agctcctgg  agagcgcat  aaagaggaa  aacaggagt  tgactttct  1920
ccctcggct  gcggtggga  ctttaacat  tccgtcagt  gggatattg  tggtttaat  1980
acccgggct  tgctgaccg  caattttga  agcgcagtt  acctttgtt  acacgataa  2040
cgaatggct  atgccatca  attagccat  gcaggtggg  aggagctct  ggctcaaac  2100
cagaagaaa  actttgcaa  atcccaaag  aagattacc  ggcttatca  tgcggtggt  2160
atgaagaac  ggaaggaga  tgttgaatc  tgtgatctt  aaaattgga  agaggcttt  2220
gctgcggtc  tcacttatg  taagccaga  gagttctcc  ccctgtgtg  tctcttggg  2280
gccaggctt  aaagtgaag  agacagcct  ctgcggact  aggcctgcc  ctgctatat  2340
tgtgccggg  atgtagaga  attagttgc  tgttggacc  aagctcaag  tggtagcaa  2400
cccttgtct  tccaggatc  gattgagaa  gttgtcatc  tccgaaaag  tgtacagct  2460
acgcaagcc  tggacacga  cactgtcgg  gctcttctg  ccgagaaga  gagtcagta  2520
gccaacttg  tggcagccc  gggcagcat  gccgcggcc  tggcgtttc  gcctgacaa  2580
accaaccag  cagatatcg  gcagctgcg  gacagactc  gcagagctc  aggcaggtc  2640
gtgccgggg  aggagtcct  taggagctc  tacgagggg  agccgctgc  caagggcgg  2700
cccgggccg  ttgctggtc  cccgcaggt  tccagagtt  aaagtcagc  atattatcc  2760
caggttaga  ttgccccta  tgtcactac  tggagtgac  gaactccca  tgccctccc  2820
agccatcca  ctgcagcct  tccctctga  acacaggga  ggaatcctc  acctccagg  2880
ttcataatg  atggcaacg  tgttccaaa  agccctgcc  cactgccga  gtctccagg  2940
cacatgcac  gccagccac  accttatcc  cagccgcag  cttaccagc  agcccagca  3000
tattccttg  gaacagggg  gtcagcagt  tatcgacct  aacagcctg  tgctcctcc  3060
gcttctaag  gttacccta  cgccccata  gtatctcct  tcgcttcct  ctccgggca  3120
cctcatatg  acacagcac  gccagcctc  tcccctacc  ccagctctg  tcctcttcc  3180
cctccccct  cctctggag  gtccttcca  catggcgga  caggagctc  accgtcatc  3240
tcagcttat  cactgcctc  tggaacaac  ggtacaccg  ctgctgcca  tgagctgcc  3300
gcgtcccag  gaacaggtc  tcagaatgg  tggaatgat  ctcccgctt  gaacagagt  3360
ccgaagaag  agaagctgc  tgagaactt  atgcctcct  tccccatta  gtcaccaat  3420
atgaaccct  ggggagatc  ccagccaca  gggctgcag  aacagcctt  agcttcagg  3480
ccacggtca  gccacgcct  cttcccgca  ccgcaccta  ccggcggcc  gcccttcca  3540
gggatccag  agcctcttg  tcaaacagg  atgccaccg  ctttctcga  gcccaacac  3600
gaaggggcc  ccggcgctc  cattgggaa  accatccag  atgtgcagg  tctgccaac  3660
gaaaaaatt  ccaagaagc  tattccaga  gagcacctc  ttctaaaga  tacgtttga  3720
gaccttatc  agcgctgcc  ctcctcagc  acagacccc  aaaccaaga  gaagctgga  3780
gacgccagc  aacgcctgg  gtgtctgta  gacaaactt  gggaccaga  actttctcc  3840
acaatcatc  gcggtctcc  cagcattgc  aggagcatt  agacgagga  ctactctga  3900
gggttgacc  tccacactc  catcgtcag  accagcaac  tcagtgaga  ctcagcctt  3960
atgccagtc  tcaaggttg  gctcagcca  gccagtaag  tgggcgtct  agacagctg  4020
catgacctc  gactccgcc  cttctccaa  gaaagccat  ctaagactg  gaccagccc  4080
tcattagca  gtttccatg  cacccgcca  ccaggagct  tgacatttc  gcaggcaaa  4140
tcccctaga  ctgcttgaa  cccccctcc  accccgccc  tgctttcct  tgttttaat  4200
ccctcgccc  ttatgattt  cccattctg  aaatagtgt  tttcctgga  tacacatag  4260
gtggtttcc  gagggattc  gacaaaatg  ggtttttaa  acttgggtg  actttttag  4320
aaaattgca  ctggctgtg  ataaaacag  cctaaaata  atttcttta  tgtcttccc  4380
accttcttc  cgttcatca  attaaagtt  taatcccat  tt  4422



<210> 715
<211> 1249
<212> PRT
<213> Rattus norvegicus
<308> AAD01990
<400> 715

Met Lys Leu Lys Glu Ile Asp Arg Thr Ala Met Gln Ala Trp Ser Pro 
  1               5                  10                  15
Ala Gln Asn His Pro Ile Tyr Leu Ala Thr Gly Thr Ser Ala Gln Gln 
             20                  25                  30
Leu Asp Ala Thr Phe Ser Thr Asn Ala Ser Leu Glu Ile Phe Glu Leu 
         35                  40                  45
Asp Leu Ser Asp Pro Ser Leu Asp Met Lys Ser Cys Ala Thr Phe Ser 
     50                  55                  60
Ser Ser His Arg Tyr His Lys Leu Ile Trp Gly Pro His Lys Met Asp 
 65                  70                  75                  80
Ser Lys Gly Asp Val Ser Gly Val Leu Ile Ala Gly Gly Glu Asn Gly 
                 85                  90                  95
Asn Ile Ile Leu Tyr Asp Pro Ser Lys Ile Ile Ala Gly Asp Lys Glu 
             100                105                110
Val Val Ile Ala Gln Lys Asp Lys His Thr Gly Pro Val Arg Ala Leu 
         115                120                125
Asp Val Asn Ile Phe Gln Thr Asn Leu Val Ala Ser Gly Ala Asn Glu 
     130                135                140
Ser Glu Ile Tyr Ile Trp Asp Leu Asn Asn Phe Ala Thr Pro Met Thr 
 145                150                155                160
Pro Gly Ala Lys Thr Gln Pro Pro Glu Asp Ile Ser Cys Ile Ala Trp 
                 165                170                175
Asn Arg Gln Val Gln His Ile Leu Ala Ser Ala Ser Pro Ser Gly Arg 
             180                185                190
Ala Thr Val Trp Asp Leu Arg Lys Asn Glu Pro Ile Ile Lys Val Ser 
         195                200                205
Asn His Ser Asn Trp Met His Cys Ser Gly Leu Ala Trp His Pro Asp 
     210                215                220
Val Ala Thr Gln Met Val Leu Ala Ser Glu Asp Asp Arg Leu Pro Val 
 225                230                235                240
Val Gln Met Trp Asp Leu Arg Phe Ala Ser Ser Pro Leu Arg Val Leu 
                 245                250                255
Glu Asn His Ala Arg Gly Ile Leu Ala Ile Ala Trp Ser Met Ala Asp 
             260                265                270
Pro Glu Leu Leu Leu Ser Cys Gly Lys Asp Ala Lys Ile Leu Cys Ser 
         275                280                285
Asn Pro Asn Thr Gly Glu Val Leu Tyr Glu Leu Pro Thr Asn Thr Gln 
     290                295                300
Trp Cys Phe Asp Ile Gln Trp Cys Pro Arg Asn Pro Ala Val Leu Ser 
 305                310                315                320
Ala Ala Ser Phe Asp Gly Arg Ile Arg Val Tyr Ser Ile Met Gly Gly 
                 325                330                335
Ser Ile Asp Gly Leu Arg Gln Lys Gln Val Asp Lys Leu Ser Ser Ser 
             340                345                350
Phe Gly Asn Leu Asp Pro Phe Gly Thr Gly Gln Pro Leu Pro Pro Leu 
         355                360                365
Gln Ile Pro Gln Gln Thr Ser Gln His Ser Ile Val Leu Pro Leu Lys 
     370                375                380
Lys Pro Pro Lys Trp Ile Arg Arg Pro Val Gly Ala Ser Phe Ser Phe 
 385                390                395                400
Gly Gly Lys Leu Val Thr Phe Glu Asn Val Thr Gly Gln Pro Gln Gln 
                 405                410                415
Gly Ala Glu Gln Pro Arg Arg Gln Pro Val Phe Ile Ser Gln Val Val 
             420                425                430
Thr Glu Lys Asp Phe Leu Ser Arg Ser Glu Gln Leu Gln His Val Val 
         435                440                445
Glu Ser Gln Gly Phe Ile Ser Tyr Cys Gln Lys Lys Ile Asp Ala Ser 
     450                455                460
Gln Thr Asp Phe Glu Lys Asn Val Trp Ser Phe Leu Lys Val Lys Phe 
 465                470                475                480
Glu Glu Asp Ser Arg Gly Lys Tyr Leu Glu Leu Leu Gly Tyr Arg Arg 
                 485                490                495
Glu Asp Leu Gly Glu Lys Ile Ala Leu Ala Leu Asn Arg Val Asp Gly 
             500                505                510
Ser Asp Val Ala Leu Lys Asp Ser Asp Arg Val Ala Gln Ser Asp Gly 
         515                520                525
Glu Glu Ser Pro Ala Glu Glu Gly Gln Leu Leu Gly Glu Arg Ile Lys 
     530                535                540
Glu Glu Lys Gln Glu Cys Asp Phe Leu Pro Ser Ala Gly Gly Gly Thr 
 545                550                555                560
Phe Asn Ile Ser Val Ser Gly Asp Ile Asp Gly Leu Ile Thr Arg Ala 
                 565                570                575
Leu Leu Thr Gly Asn Phe Glu Ser Ala Val Asp Leu Cys Leu His Asp 
             580                585                590
Asn Arg Met Ala Asp Ala Ile Ile Leu Ala Ile Ala Gly Gly Gln Glu 
         595                600                605
Leu Leu Ala Gln Thr Gln Lys Lys Tyr Phe Ala Lys Ser Gln Ser Lys 
     610                615                620
Ile Thr Arg Leu Ile Thr Ala Val Val Met Lys Asn Trp Lys Glu Ile 
 625                630                635                640
Val Glu Ser Cys Asp Leu Lys Asn Trp Arg Glu Ala Leu Ala Ala Val 
                 645                650                655
Leu Thr Tyr Ala Lys Pro Asp Glu Phe Ser Ala Leu Cys Asp Leu Leu 
             660                665                670
Gly Ala Arg Leu Glu Ser Glu Gly Asp Ser Leu Leu Arg Thr Gln Ala 
         675                680                685
Cys Leu Cys Tyr Ile Cys Ala Gly Asn Val Glu Arg Leu Val Ala Cys 
     690                695                700
Trp Thr Lys Ala Gln Asp Gly Ser Asn Pro Leu Ser Leu Gln Asp Leu 
 705                710                715                720
Ile Glu Lys Val Val Ile Leu Arg Lys Ala Val Gln Leu Thr Gln Ala 
                 725                730                735
Leu Asp Thr Asn Thr Val Gly Ala Leu Leu Ala Glu Lys Met Ser Gln 
             740                745                750
Tyr Ala Asn Leu Leu Ala Ala Gln Gly Ser Ile Ala Ala Ala Leu Ala 
         755                760                765
Phe Leu Pro Asp Asn Thr Asn Gln Pro Asp Ile Val Gln Leu Arg Asp 
     770                775                780
Arg Leu Cys Arg Ala Gln Gly Arg Ser Val Pro Gly Gln Glu Ser Ser 
 785                790                795                800
Arg Ser Ser Tyr Glu Gly Gln Pro Leu Pro Lys Gly Gly Pro Gly Pro 
                 805                810                815
Phe Ala Gly His Pro Gln Val Ser Arg Val Gln Ser Gln Gln Tyr Tyr 
             820                825                830
Pro Gln Val Arg Ile Ala Pro Thr Val Thr Thr Trp Ser Asp Arg Thr 
         835                840                845
Pro Thr Ala Leu Pro Ser His Pro Pro Ala Ala Cys Pro Ser Asp Thr 
     850                855                860
Gln Gly Gly Asn Pro Pro Pro Pro Gly Phe Ile Met His Gly Asn Val 
 865                870                875                880
Val Pro Asn Ser Pro Ala Pro Leu Pro Thr Ser Pro Gly His Met His 
                 885                890                895
Ser Gln Pro Pro Pro Tyr Pro Gln Pro Gln Pro Tyr Gln Pro Ala Gln 
             900                905                910
Gln Tyr Ser Leu Gly Thr Gly Gly Ser Ala Val Tyr Arg Pro Gln Gln 
         915                920                925
Pro Val Ala Pro Pro Ala Ser Lys Arg Tyr Pro Asn Ala Pro Tyr Val 
     930                935                940
Ser Pro Val Ala Ser Tyr Ser Gly Gln Pro His Met Tyr Thr Ala Gln 
 945                950                955                960
Pro Ala Ser Ser Pro Thr Ser Ser Ser Ala Pro Leu Pro Pro Pro Pro 
                 965                970                975
Ser Ser Gly Ala Ser Phe Gln His Gly Gly Pro Gly Ala Pro Pro Ser 
             980                985                990
Ser Ser Ala Tyr Ala Leu Pro Pro Gly Thr Thr Gly Thr Pro Pro Ala 
         995                1000                1005
Ala Ser Glu Leu Pro Ala Ser Gln Arg Thr Gly Pro Gln Asn Gly Trp 
     1010                1015                1020
Asn Asp Pro Pro Ala Leu Asn Arg Val Pro Lys Lys Lys Lys Leu Pro 
 1025                1030                1035                1040
Glu Asn Phe Met Pro Pro Val Pro Ile Thr Ser Pro Ile Met Asn Pro 
                 1045                1050                1055
Gly Gly Asp Pro Gln Pro Gln Gly Leu Gln Gln Gln Pro Ser Ala Ser 
             1060                1065                1070
Gly Pro Arg Ser Ser His Ala Ser Phe Pro Gln Pro His Leu Ala Gly 
         1075                1080                1085
Gly Gln Pro Phe His Gly Ile Gln Gln Pro Leu Ala Gln Thr Gly Met 
     1090                1095                1100
Pro Pro Ser Phe Ser Lys Pro Asn Thr Glu Gly Ala Pro Gly Ala Pro 
 1105                1110                1115                1120
Ile Gly Asn Thr Ile Gln His Val Gln Ala Leu Pro Thr Glu Lys Ile 
                 1125                1130                1135
Thr Lys Lys Pro Ile Pro Asp Glu His Leu Ile Leu Lys Thr Thr Phe 
             1140                1145                1150
Glu Asp Leu Ile Gln Arg Cys Leu Ser Ser Ala Thr Asp Pro Gln Thr 
         1155                1160                1165
Lys Arg Lys Leu Asp Asp Ala Ser Lys Arg Leu Glu Cys Leu Tyr Asp 
     1170                1175                1180
Lys Leu Arg Asp Gln Thr Leu Ser Pro Thr Ile Ile Ser Gly Leu His 
 1185                1190                1195                1200
Ser Ile Ala Arg Ser Ile Glu Thr Arg Asn Tyr Ser Glu Gly Leu Thr 
                 1205                1210                1215
Val His Thr His Ile Val Ser Thr Ser Asn Phe Ser Glu Thr Ser Ala 
             1220                1225                1230
Phe Met Pro Val Leu Lys Val Val Leu Ser Gln Ala Ser Lys Leu Gly 
         1235                1240                1245
Val 
     1250



<210> 716
<211> 4110
<212> DNA
<213> Homo sapiens
<308> AB020712
<400> 716

gcggaatag  gggttttgc  gcaaccggt  tattttcct  ctgttttca  ccattctgg  60
acaatctgg  gccatcgtc  ttcttgtga  gccaagcct  aaaatgcga  gcagagagg  120
aggaccaaa  ttgaggcga  tccaggaac  tgccaatgg  tctccgggt  cggtctctg  180
aactggagg  tatcgggag  aaaggctct  cgatgcgga  ataatgggg  agctcttgg  240
atggttggc  gtaggtatg  gataccgga  gagcaggag  caaatagga  acgccgact  300
ttaattcaa  gaacccttt  ctgaaacac  ttgccacaa  gaaggaaat  agattacag  360
cgaagatac  tattaagga  gaagttaaa  gaagtagat  gtacagcca  gcaggcatg  420
agccctgcc  agaatcacc  catttacct  gcaacagga  catctgctc  gcaattgga  480
gcaacattt  gtacgaatg  ttcccttga  atatttgaa  tagacctct  tgatccatc  540
ttggatatg  aatcttgtg  cacattctc  tcttctcac  ggtaccaca  gttgatttg  600
gggccttat  aaatggatt  caaaggaga  gtctctgga  ttctgattg  aggtggtga  660
aatggaaat  ttattctct  tgatccttc  aaaattata  ctggagaca  ggaagttgt  720
attgcccag  atgacaagc  tactggccc  gtgagagcc  tggatgtga  cattttcca  780
actaatctg  tagcttctg  tgctaatga  tctgaaatc  acatatggg  tctaaataa  840
tttgcaacc  caatgacac  aggagccaa  acacagccg  cagaagata  cagctgcat  900
gcatggaac  gacaagttc  gcatatttt  gcatcagcc  gtcccagtg  ccgggccac  960
gtatgggat  ttaggaaaa  tgagccaat  atcaaagtc  gtgaccata  taacagaat  1020
cattgttct  ggttggcat  gcatcctga  gttgctact  agatggtcc  tgcctccga  1080
gatgaccgg  taccagtga  ccagatgtg  gatcttcga  ttgcttcct  tccacttcg  1140
gtcctggaa  accatgcca  ggggatttt  gcaattgct  ggagcatgg  agatcctga  1200
ttgttactg  gctgtggaa  agatgctaa  attctctgc  ccaatccaa  cacaggaga  1260
gtgttatat  aacttccca  caacacaca  tggtgcttc  atattcagt  gtgtccccg  1320
aatcctgct  tcttatcag  tgcttcgtt  gatgggcgt  tcagtgttt  ttctatcat  1380
ggaggaagc  cagatggtt  aagacagaa  caagttgac  agctttcat  atcttttgg  1440
aatcttgat  cctttggca  aggacagcc  cttcctccg  tacaaattc  acagcagac  1500
gctcagcat  gtatagtgc  gcctctgaa  aagccgccc  agtggattc  aaggcctgt  1560
ggtgcttct  tttcatttg  aggcaaact  gttacgttt  agaatgtca  aatgccttc  1620
catcaggga  ctgagcagc  gcagcagca  caccatgtg  tcattagtc  ggttgtaac  1680
gaaaaggag  tcctcagcc  atcagacca  cttcagcag  ctgtgcagt  acaaggatt  1740
atcaattat  gccaaaaaa  aattgatgc  tctcagact  aatttgaga  aaatgtgtg  1800
tcctttttg  aggtaaact  tgaggatga  tctcgtgga  aataccttg  acttctagg  1860
tacagaaaa  aagatctag  aaagaagat  gctttggcc  tgaacaaag  ggatggagc  1920
aatgtggct  ttaaagact  tgaccaagt  gcacagagt  atggggagg  gagccctgc  1980
gctgaagag  agctcttgg  agagcacat  aaagaggaa  aagaagaat  tgaatttct  2040
ccctcatct  gaggaacat  taatatctc  gtcagtggg  acattgatg  tttaattac  2100
caggctttg  tgacgggca  ttttgagag  gctgttgac  tttgtttac  tgataaccg  2160
atggccgat  ccattatat  ggccatagc  ggtggacaa  aactcttgg  tcgaaccca  2220
aaaaaatac  tcgcaaaat  ccaaagcaa  attaccagg  tcatcactg  agtggtgat  2280
aagaactgg  aagagattg  tgagtcttg  gatcttaaa  attggagag  ggctttagc  2340
gcagtattg  cttatgcaa  gccggatga  ttttcagcc  tttgtgatc  tttgggaac  2400
aggcttgaa  atgaaggag  tagcctcct  cagactcaa  catgtctct  ctatatttg  2460
gcagggaat  tagagaaat  agttgcatg  tggactaaa  ctcaagatg  aagccaccc  2520
ttgtcactt  aggatctga  tgagaaagt  gtcatcctg  gaaaagctg  gcaactcac  2580
caagccatg  acactagta  tgtaggagt  ctcttggct  cgaagatga  tcagtatgc  2640
aatttgttg  cagctcagg  cagtattgc  gcagccttg  cttttcttc  tgacaacac  2700
aaccagcca  atatcatgc  gcttcgtga  agactttgt  gagcacaag  agagcctgt  2760
gcaggacat  aatcaccta  aattccgta  gagaaacag  agctcccca  gggcaggcc  2820
ggaccagtt  ctggccacc  ccagatgcc  agagttcaa  ctcaacaat  ttatcccca  2880
ggagaaaat  ctccacctc  gggtttcat  atgcatgga  atgttaatc  aaatgctgc  2940
ggtcagctt  ccacatctc  aggtcatat  cacacccag  taccacctt  tccacagcc  3000
cagccttat  aaccagccc  gccgtatcc  ttcggaaca  gggggtcag  aatgtatcg  3060
cctcagcag  ctgttgctc  tcctacttc  aacgcttac  ctaacaccc  ttacatatc  3120
tctgcttct  cctatactg  gcagtctca  ctgtacgca  cacagcacc  ggcctcttc  3180
cctacctcc  gccctgcta  ttctttccc  cctccccct  cctctggag  atccttcca  3240
catggcgga  caggagctc  accatcatc  tcagcttat  cactgcctc  tggaacaac  3300
ggtacactg  ctgctgcca  tgagctgcc  gcgtcccaa  gaacaggtc  tcagaatgg  3360
tggaatgac  ctccagctt  gaacagagt  cccaaaaag  agaagatgc  tgaaaactt  3420
atgcctcct  ttcccatca  atcaccaat  atgaacccg  tgggtgacc  ccagtcaca  3480
atgctgcag  aacagcctt  agctccagt  ccactgtca  gccagtctt  attcccaca  3540
ccacatctt  caggtggcc  gcccttcca  ggcgtacag  aacctcttg  tcaaacagg  3600
atgccacca  ctttttcaa  gcccaatat  gaaggtgcc  caggggctc  tattggaaa  3660
accttccag  atgtgcagt  tttgccaac  aaaaaaatt  ccaagaaac  tattccaga  3720
gagcacctc  ttctaaaga  cacatttga  gatcttatt  agcgctgcc  ttcttcagc  3780
acagaccct  aaaccaaga  gaagctaga  gatgccagc  aacgtttgg  gtttctgta  3840
gataaactt  gggaacaga  actttcacc  acaatcacc  gtggtttac  caacattgc  3900
aggagcatt  aaactcgaa  ctactcaga  ggattgacc  tgcataccc  catagttag  3960
accagcaac  tcagtgaga  ctctgcttt  atgccagtt  tcaaagttg  tctcaccca  4020
gccaataag  tgggtgtct  aaaggacag  ttctcttcc  ctcaatatt  ccatttttc  4080
aaagaaaca  gttaaaaaa  aaaaaaaaaa  4110



<210> 717
<211> 1220
<212> PRT
<213> Homo sapiens
<308> BAA74928
<400> 717

Met Lys Leu Lys Glu Val Asp Arg Thr Ala Met Gln Ala Trp Ser Pro 
  1               5                  10                  15
Ala Gln Asn His Pro Ile Tyr Leu Ala Thr Gly Thr Ser Ala Gln Gln 
             20                  25                  30
Leu Asp Ala Thr Phe Ser Thr Asn Ala Ser Leu Glu Ile Phe Glu Leu 
         35                  40                  45
Asp Leu Ser Asp Pro Ser Leu Asp Met Lys Ser Cys Ala Thr Phe Ser 
     50                  55                  60
Ser Ser His Arg Tyr His Lys Leu Ile Trp Gly Pro Tyr Lys Met Asp 
 65                  70                  75                  80
Ser Lys Gly Asp Val Ser Gly Val Leu Ile Ala Gly Gly Glu Asn Gly 
                 85                  90                  95
Asn Ile Ile Leu Tyr Asp Pro Ser Lys Ile Ile Ala Gly Asp Lys Glu 
             100                105                110
Val Val Ile Ala Gln Asn Asp Lys His Thr Gly Pro Val Arg Ala Leu 
         115                120                125
Asp Val Asn Ile Phe Gln Thr Asn Leu Val Ala Ser Gly Ala Asn Glu 
     130                135                140
Ser Glu Ile Tyr Ile Trp Asp Leu Asn Asn Phe Ala Thr Pro Met Thr 
 145                150                155                160
Pro Gly Ala Lys Thr Gln Pro Pro Glu Asp Ile Ser Cys Ile Ala Trp 
                 165                170                175
Asn Arg Gln Val Gln His Ile Leu Ala Ser Ala Ser Pro Ser Gly Arg 
             180                185                190
Ala Thr Val Trp Asp Leu Arg Lys Asn Glu Pro Ile Ile Lys Val Ser 
         195                200                205
Asp His Ser Asn Arg Met His Cys Ser Gly Leu Ala Trp His Pro Asp 
     210                215                220
Val Ala Thr Gln Met Val Leu Ala Ser Glu Asp Asp Arg Leu Pro Val 
 225                230                235                240
Ile Gln Met Trp Asp Leu Arg Phe Ala Ser Ser Pro Leu Arg Val Leu 
                 245                250                255
Glu Asn His Ala Arg Gly Ile Leu Ala Ile Ala Trp Ser Met Ala Asp 
             260                265                270
Pro Glu Leu Leu Leu Ser Cys Gly Lys Asp Ala Lys Ile Leu Cys Ser 
         275                280                285
Asn Pro Asn Thr Gly Glu Val Leu Tyr Glu Leu Pro Thr Asn Thr Gln 
     290                295                300
Trp Cys Phe Asp Ile Gln Trp Cys Pro Arg Asn Pro Ala Val Leu Ser 
 305                310                315                320
Ala Ala Ser Phe Asp Gly Arg Ile Ser Val Tyr Ser Ile Met Gly Gly 
                 325                330                335
Ser Thr Asp Gly Leu Arg Gln Lys Gln Val Asp Lys Leu Ser Ser Ser 
             340                345                350
Phe Gly Asn Leu Asp Pro Phe Gly Thr Gly Gln Pro Leu Pro Pro Leu 
         355                360                365
Gln Ile Pro Gln Gln Thr Ala Gln His Ser Ile Val Leu Pro Leu Lys 
     370                375                380
Lys Pro Pro Lys Trp Ile Arg Arg Pro Val Gly Ala Ser Phe Ser Phe 
 385                390                395                400
Gly Gly Lys Leu Val Thr Phe Glu Asn Val Arg Met Pro Ser His Gln 
                 405                410                415
Gly Ala Glu Gln Gln Gln Gln Gln His His Val Phe Ile Ser Gln Val 
             420                425                430
Val Thr Glu Lys Glu Phe Leu Ser Arg Ser Asp Gln Leu Gln Gln Ala 
         435                440                445
Val Gln Ser Gln Gly Phe Ile Asn Tyr Cys Gln Lys Lys Ile Asp Ala 
     450                455                460
Ser Gln Thr Glu Phe Glu Lys Asn Val Trp Ser Phe Leu Lys Val Asn 
 465                470                475                480
Phe Glu Asp Asp Ser Arg Gly Lys Tyr Leu Glu Leu Leu Gly Tyr Arg 
                 485                490                495
Lys Glu Asp Leu Gly Lys Lys Ile Ala Leu Ala Leu Asn Lys Val Asp 
             500                505                510
Gly Ala Asn Val Ala Leu Lys Asp Ser Asp Gln Val Ala Gln Ser Asp 
         515                520                525
Gly Glu Glu Ser Pro Ala Ala Glu Glu Gln Leu Leu Gly Glu His Ile 
     530                535                540
Lys Glu Glu Lys Glu Glu Ser Glu Phe Leu Pro Ser Ser Gly Gly Thr 
 545                550                555                560
Phe Asn Ile Ser Val Ser Gly Asp Ile Asp Gly Leu Ile Thr Gln Ala 
                 565                570                575
Leu Leu Thr Gly Asn Phe Glu Ser Ala Val Asp Leu Cys Leu His Asp 
             580                585                590
Asn Arg Met Ala Asp Ala Ile Ile Leu Ala Ile Ala Gly Gly Gln Glu 
         595                600                605
Leu Leu Ala Arg Thr Gln Lys Lys Tyr Phe Ala Lys Ser Gln Ser Lys 
     610                615                620
Ile Thr Arg Leu Ile Thr Ala Val Val Met Lys Asn Trp Lys Glu Ile 
 625                630                635                640
Val Glu Ser Cys Asp Leu Lys Asn Trp Arg Glu Ala Leu Ala Ala Val 
                 645                650                655
Leu Thr Tyr Ala Lys Pro Asp Glu Phe Ser Ala Leu Cys Asp Leu Leu 
             660                665                670
Gly Thr Arg Leu Glu Asn Glu Gly Asp Ser Leu Leu Gln Thr Gln Ala 
         675                680                685
Cys Leu Cys Tyr Ile Cys Ala Gly Asn Val Glu Lys Leu Val Ala Cys 
     690                695                700
Trp Thr Lys Ala Gln Asp Gly Ser His Pro Leu Ser Leu Gln Asp Leu 
 705                710                715                720
Ile Glu Lys Val Val Ile Leu Arg Lys Ala Val Gln Leu Thr Gln Ala 
                 725                730                735
Met Asp Thr Ser Thr Val Gly Val Leu Leu Ala Ala Lys Met Ser Gln 
             740                745                750
Tyr Ala Asn Leu Leu Ala Ala Gln Gly Ser Ile Ala Ala Ala Leu Ala 
         755                760                765
Phe Leu Pro Asp Asn Thr Asn Gln Pro Asn Ile Met Gln Leu Arg Asp 
     770                775                780
Arg Leu Cys Arg Ala Gln Gly Glu Pro Val Ala Gly His Glu Ser Pro 
 785                790                795                800
Lys Ile Pro Tyr Glu Lys Gln Gln Leu Pro Lys Gly Arg Pro Gly Pro 
                 805                810                815
Val Ala Gly His His Gln Met Pro Arg Val Gln Thr Gln Gln Tyr Tyr 
             820                825                830
Pro His Gly Glu Asn Pro Pro Pro Pro Gly Phe Ile Met His Gly Asn 
         835                840                845
Val Asn Pro Asn Ala Ala Gly Gln Leu Pro Thr Ser Pro Gly His Met 
     850                855                860
His Thr Gln Val Pro Pro Tyr Pro Gln Pro Gln Pro Tyr Gln Pro Ala 
 865                870                875                880
Gln Pro Tyr Pro Phe Gly Thr Gly Gly Ser Ala Met Tyr Arg Pro Gln 
                 885                890                895
Gln Pro Val Ala Pro Pro Thr Ser Asn Ala Tyr Pro Asn Thr Pro Tyr 
             900                905                910
Ile Ser Ser Ala Ser Ser Tyr Thr Gly Gln Ser Gln Leu Tyr Ala Ala 
         915                920                925
Gln His Gln Ala Ser Ser Pro Thr Ser Ser Pro Ala Thr Ser Phe Pro 
     930                935                940
Pro Pro Pro Ser Ser Gly Ala Ser Phe Gln His Gly Gly Pro Gly Ala 
 945                950                955                960
Pro Pro Ser Ser Ser Ala Tyr Ala Leu Pro Pro Gly Thr Thr Gly Thr 
                 965                970                975
Leu Pro Ala Ala Ser Glu Leu Pro Ala Ser Gln Arg Thr Gly Pro Gln 
             980                985                990
Asn Gly Trp Asn Asp Pro Pro Ala Leu Asn Arg Val Pro Lys Lys Lys 
         995                1000                1005
Lys Met Pro Glu Asn Phe Met Pro Pro Val Pro Ile Thr Ser Pro Ile 
     1010                1015                1020
Met Asn Pro Leu Gly Asp Pro Gln Ser Gln Met Leu Gln Gln Gln Pro 
 1025                1030                1035                1040
Ser Ala Pro Val Pro Leu Ser Ser Gln Ser Ser Phe Pro Gln Pro His 
                 1045                1050                1055
Leu Pro Gly Gly Gln Pro Phe His Gly Val Gln Gln Pro Leu Gly Gln 
             1060                1065                1070
Thr Gly Met Pro Pro Ser Phe Ser Lys Pro Asn Ile Glu Gly Ala Pro 
         1075                1080                1085
Gly Ala Pro Ile Gly Asn Thr Phe Gln His Val Gln Ser Leu Pro Thr 
     1090                1095                1100
Lys Lys Ile Thr Lys Lys Pro Ile Pro Asp Glu His Leu Ile Leu Lys 
 1105                1110                1115                1120
Thr Thr Phe Glu Asp Leu Ile Gln Arg Cys Leu Ser Ser Ala Thr Asp 
                 1125                1130                1135
Pro Gln Thr Lys Arg Lys Leu Asp Asp Ala Ser Lys Arg Leu Glu Phe 
             1140                1145                1150
Leu Tyr Asp Lys Leu Arg Glu Gln Thr Leu Ser Pro Thr Ile Thr Ser 
         1155                1160                1165
Gly Leu His Asn Ile Ala Arg Ser Ile Glu Thr Arg Asn Tyr Ser Glu 
     1170                1175                1180
Gly Leu Thr Met His Thr His Ile Val Ser Thr Ser Asn Phe Ser Glu 
 1185                1190                1195                1200
Thr Ser Ala Phe Met Pro Val Leu Lys Val Val Leu Thr Gln Ala Asn 
                 1205                1210                1215
Lys Leu Gly Val 
             1220



<210> 718
<211> 4422
<212> DNA
<213> Rattus norvegicus
<308> AF034582
<400> 718

gatcctggg  gagtccgac  ttcgccggc  aacgcagga  aggtcactg  ggtccgcca  60
gtgtgtccg  cgtttgttt  ctgcccctc  ccaggttcg  tgtccgctg  cgaggcccg  120
ggcccttct  ccgctgtcg  cgcgccccc  tgtctcgtt  cggccccgc  gggacaacg  180
ctggagtcg  agcagccgg  tgatcgcgc  cgtcatcct  taccaacgt  tccaggctg  240
cctgctcgg  agtgggtga  aatgaagct  aaggagata  accgcacag  gatgcaggc  300
tggagccct  cccagaacc  ccccattta  ctggccaca  ggacatctg  tcagcagtt  360
gacgcgaca  tcagtacca  cgcttccct  gagatattc  agctcgacc  ttccgaccc  420
tccttggat  tgaagtcct  tgctacttt  tcctcgtct  acaggtacc  caagttgat  480
tggggacct  ataaaatgg  ttccaaagg  gatgtttct  gagttttga  tgcaggtgg  540
gaaaatgga  acattattc  ctacgatcc  tctaaaatt  tagctggag  caaggaagt  600
gtgattgcc  aaaaggaca  gcatactgg  ccagtgaga  ccttggatg  aaacatctt  660
cagaccaat  tggtggcct  tggtgctaa  gaatctgaa  tctacattt  ggatctaaa  720
aattttgca  ctccaatga  gccaggagc  aaaacacag  caccagaag  tatcagctg  780
atagcctgg  acagacagg  ccagcatat  ttagcatca  ccagtccca  tggccgggc  840
acggtctgg  atctcagga  aaacgagcc  attatcaaa  tcagcaacc  cagtaactg  900
atgcactgc  ctgggctgg  atggcaccc  gatgtcgct  ctcagatgg  ccttgcttc  960
gaggatgat  gattaccag  ggtccagat  tgggatctt  gatttgctt  ctctcccct  1020
cgggttctg  aaaatcatg  cagggggat  ttggcaatt  cttggagca  ggcagatcc  1080
gaattgttg  taagctgtg  aaaagatgc  aagattctc  gctctaacc  taacacggg  1140
gaggtatta  atgaacttc  caccaacac  cagtggtgc  ttgatatcc  gtggtgtcc  1200
cggaatcct  ccgtcctgt  tgccgcttc  ttcgatggt  gcatccgtg  ctactccat  1260
atgggaggg  gcatagacg  cttaaggca  aaacaagtt  acaagcttt  gtcgtcttt  1320
gggaatctt  atccgtttg  cacaggaca  ccgctccct  cattacaaa  cccacagca  1380
acttcacag  acagcatcg  gctgcccct  aagaagccg  ccaagtgga  ccggagacc  1440
gtgggcgcc  ccttctcat  cggagggaa  ttggtgact  tcgagaacg  tacagggca  1500
cctcagcag  gagctgagc  gccacggcg  cagcccgtg  tcatcagtc  ggtggtgac  1560
gaaaaggac  tcctcagcc  ctcagagca  ctacagcac  tcgtcgagt  tcagggctt  1620
atcagttac  gccagaaaa  gatcgatgc  tcccagact  acttcgaga  gaatgtgtg  1680
tccttcttg  aggtaaagt  tgaggagga  tctcgtggg  aataccttg  gcttcttgg  1740
tatagaaga  aagatctgg  agagaagat  gctttggcc  tgaacagag  ggacggatc  1800
gatgtggct  ttaaggact  tgaccgcgt  gcgcagagt  atggggagg  gagccctgc  1860
gaggaaggg  agctcctgg  agagcgcat  aaagaggaa  aacaggagt  tgactttct  1920
ccctcggct  gcggtggga  ctttaacat  tccgtcagt  gggatattg  tggtttaat  1980
acccgggct  tgctgaccg  caattttga  agcgcagtt  acctttgtt  acacgataa  2040
cgaatggct  atgccatca  attagccat  gcaggtggg  aggagctct  ggctcaaac  2100
cagaagaaa  actttgcaa  atcccaaag  aagattacc  ggcttatca  tgcggtggt  2160
atgaagaac  ggaaggaga  tgttgaatc  tgtgatctt  aaaattgga  agaggcttt  2220
gctgcggtc  tcacttatg  taagccaga  gagttctcc  ccctgtgtg  tctcttggg  2280
gccaggctt  aaagtgaag  agacagcct  ctgcggact  aggcctgcc  ctgctatat  2340
tgtgccggg  atgtagaga  attagttgc  tgttggacc  aagctcaag  tggtagcaa  2400
cccttgtct  tccaggatc  gattgagaa  gttgtcatc  tccgaaaag  tgtacagct  2460
acgcaagcc  tggacacga  cactgtcgg  gctcttctg  ccgagaaga  gagtcagta  2520
gccaacttg  tggcagccc  gggcagcat  gccgcggcc  tggcgtttc  gcctgacaa  2580
accaaccag  cagatatcg  gcagctgcg  gacagactc  gcagagctc  aggcaggtc  2640
gtgccgggg  aggagtcct  taggagctc  tacgagggg  agccgctgc  caagggcgg  2700
cccgggccg  ttgctggtc  cccgcaggt  tccagagtt  aaagtcagc  atattatcc  2760
caggttaga  ttgccccta  tgtcactac  tggagtgac  gaactccca  tgccctccc  2820
agccatcca  ctgcagcct  tccctctga  acacaggga  ggaatcctc  acctccagg  2880
ttcataatg  atggcaacg  tgttccaaa  agccctgcc  cactgccga  gtctccagg  2940
cacatgcac  gccagccac  accttatcc  cagccgcag  cttaccagc  agcccagca  3000
tattccttg  gaacagggg  gtcagcagt  tatcgacct  aacagcctg  tgctcctcc  3060
gcttctaag  gttacccta  cgccccata  gtatctcct  tcgcttcct  ctccgggca  3120
cctcatatg  acacagcac  gccagcctc  tcccctacc  ccagctctg  tcctcttcc  3180
cctccccct  cctctggag  gtccttcca  catggcgga  caggagctc  accgtcatc  3240
tcagcttat  cactgcctc  tggaacaac  ggtacaccg  ctgctgcca  tgagctgcc  3300
gcgtcccag  gaacaggtc  tcagaatgg  tggaatgat  ctcccgctt  gaacagagt  3360
ccgaagaag  agaagctgc  tgagaactt  atgcctcct  tccccatta  gtcaccaat  3420
atgaaccct  ggggagatc  ccagccaca  gggctgcag  aacagcctt  agcttcagg  3480
ccacggtca  gccacgcct  cttcccgca  ccgcaccta  ccggcggcc  gcccttcca  3540
gggatccag  agcctcttg  tcaaacagg  atgccaccg  ctttctcga  gcccaacac  3600
gaaggggcc  ccggcgctc  cattgggaa  accatccag  atgtgcagg  tctgccaac  3660
gaaaaaatt  ccaagaagc  tattccaga  gagcacctc  ttctaaaga  tacgtttga  3720
gaccttatc  agcgctgcc  ctcctcagc  acagacccc  aaaccaaga  gaagctgga  3780
gacgccagc  aacgcctgg  gtgtctgta  gacaaactt  gggaccaga  actttctcc  3840
acaatcatc  gcggtctcc  cagcattgc  aggagcatt  agacgagga  ctactctga  3900
gggttgacc  tccacactc  catcgtcag  accagcaac  tcagtgaga  ctcagcctt  3960
atgccagtc  tcaaggttg  gctcagcca  gccagtaag  tgggcgtct  agacagctg  4020
catgacctc  gactccgcc  cttctccaa  gaaagccat  ctaagactg  gaccagccc  4080
tcattagca  gtttccatg  cacccgcca  ccaggagct  tgacatttc  gcaggcaaa  4140
tcccctaga  ctgcttgaa  cccccctcc  accccgccc  tgctttcct  tgttttaat  4200
ccctcgccc  ttatgattt  cccattctg  aaatagtgt  tttcctgga  tacacatag  4260
gtggtttcc  gagggattc  gacaaaatg  ggtttttaa  acttgggtg  actttttag  4320
aaaattgca  ctggctgtg  ataaaacag  cctaaaata  atttcttta  tgtcttccc  4380
accttcttc  cgttcatca  attaaagtt  taatcccat  tt  4422



<210> 719
<211> 1249
<212> PRT
<213> Rattus norvegicus
<308> AAD01990
<400> 719

Met Lys Leu Lys Glu Ile Asp Arg Thr Ala Met Gln Ala Trp Ser Pro 
  1               5                  10                  15
Ala Gln Asn His Pro Ile Tyr Leu Ala Thr Gly Thr Ser Ala Gln Gln 
             20                  25                  30
Leu Asp Ala Thr Phe Ser Thr Asn Ala Ser Leu Glu Ile Phe Glu Leu 
         35                  40                  45
Asp Leu Ser Asp Pro Ser Leu Asp Met Lys Ser Cys Ala Thr Phe Ser 
     50                  55                  60
Ser Ser His Arg Tyr His Lys Leu Ile Trp Gly Pro His Lys Met Asp 
 65                  70                  75                  80
Ser Lys Gly Asp Val Ser Gly Val Leu Ile Ala Gly Gly Glu Asn Gly 
                 85                  90                  95
Asn Ile Ile Leu Tyr Asp Pro Ser Lys Ile Ile Ala Gly Asp Lys Glu 
             100                105                110
Val Val Ile Ala Gln Lys Asp Lys His Thr Gly Pro Val Arg Ala Leu 
         115                120                125
Asp Val Asn Ile Phe Gln Thr Asn Leu Val Ala Ser Gly Ala Asn Glu 
     130                135                140
Ser Glu Ile Tyr Ile Trp Asp Leu Asn Asn Phe Ala Thr Pro Met Thr 
 145                150                155                160
Pro Gly Ala Lys Thr Gln Pro Pro Glu Asp Ile Ser Cys Ile Ala Trp 
                 165                170                175
Asn Arg Gln Val Gln His Ile Leu Ala Ser Ala Ser Pro Ser Gly Arg 
             180                185                190
Ala Thr Val Trp Asp Leu Arg Lys Asn Glu Pro Ile Ile Lys Val Ser 
         195                200                205
Asn His Ser Asn Trp Met His Cys Ser Gly Leu Ala Trp His Pro Asp 
     210                215                220
Val Ala Thr Gln Met Val Leu Ala Ser Glu Asp Asp Arg Leu Pro Val 
 225                230                235                240
Val Gln Met Trp Asp Leu Arg Phe Ala Ser Ser Pro Leu Arg Val Leu 
                 245                250                255
Glu Asn His Ala Arg Gly Ile Leu Ala Ile Ala Trp Ser Met Ala Asp 
             260                265                270
Pro Glu Leu Leu Leu Ser Cys Gly Lys Asp Ala Lys Ile Leu Cys Ser 
         275                280                285
Asn Pro Asn Thr Gly Glu Val Leu Tyr Glu Leu Pro Thr Asn Thr Gln 
     290                295                300
Trp Cys Phe Asp Ile Gln Trp Cys Pro Arg Asn Pro Ala Val Leu Ser 
 305                310                315                320
Ala Ala Ser Phe Asp Gly Arg Ile Arg Val Tyr Ser Ile Met Gly Gly 
                 325                330                335
Ser Ile Asp Gly Leu Arg Gln Lys Gln Val Asp Lys Leu Ser Ser Ser 
             340                345                350
Phe Gly Asn Leu Asp Pro Phe Gly Thr Gly Gln Pro Leu Pro Pro Leu 
         355                360                365
Gln Ile Pro Gln Gln Thr Ser Gln His Ser Ile Val Leu Pro Leu Lys 
     370                375                380
Lys Pro Pro Lys Trp Ile Arg Arg Pro Val Gly Ala Ser Phe Ser Phe 
 385                390                395                400
Gly Gly Lys Leu Val Thr Phe Glu Asn Val Thr Gly Gln Pro Gln Gln 
                 405                410                415
Gly Ala Glu Gln Pro Arg Arg Gln Pro Val Phe Ile Ser Gln Val Val 
             420                425                430
Thr Glu Lys Asp Phe Leu Ser Arg Ser Glu Gln Leu Gln His Val Val 
         435                440                445
Glu Ser Gln Gly Phe Ile Ser Tyr Cys Gln Lys Lys Ile Asp Ala Ser 
     450                455                460
Gln Thr Asp Phe Glu Lys Asn Val Trp Ser Phe Leu Lys Val Lys Phe 
 465                470                475                480
Glu Glu Asp Ser Arg Gly Lys Tyr Leu Glu Leu Leu Gly Tyr Arg Arg 
                 485                490                495
Glu Asp Leu Gly Glu Lys Ile Ala Leu Ala Leu Asn Arg Val Asp Gly 
             500                505                510
Ser Asp Val Ala Leu Lys Asp Ser Asp Arg Val Ala Gln Ser Asp Gly 
         515                520                525
Glu Glu Ser Pro Ala Glu Glu Gly Gln Leu Leu Gly Glu Arg Ile Lys 
     530                535                540
Glu Glu Lys Gln Glu Cys Asp Phe Leu Pro Ser Ala Gly Gly Gly Thr 
 545                550                555                560
Phe Asn Ile Ser Val Ser Gly Asp Ile Asp Gly Leu Ile Thr Arg Ala 
                 565                570                575
Leu Leu Thr Gly Asn Phe Glu Ser Ala Val Asp Leu Cys Leu His Asp 
             580                585                590
Asn Arg Met Ala Asp Ala Ile Ile Leu Ala Ile Ala Gly Gly Gln Glu 
         595                600                605
Leu Leu Ala Gln Thr Gln Lys Lys Tyr Phe Ala Lys Ser Gln Ser Lys 
     610                615                620
Ile Thr Arg Leu Ile Thr Ala Val Val Met Lys Asn Trp Lys Glu Ile 
 625                630                635                640
Val Glu Ser Cys Asp Leu Lys Asn Trp Arg Glu Ala Leu Ala Ala Val 
                 645                650                655
Leu Thr Tyr Ala Lys Pro Asp Glu Phe Ser Ala Leu Cys Asp Leu Leu 
             660                665                670
Gly Ala Arg Leu Glu Ser Glu Gly Asp Ser Leu Leu Arg Thr Gln Ala 
         675                680                685
Cys Leu Cys Tyr Ile Cys Ala Gly Asn Val Glu Arg Leu Val Ala Cys 
     690                695                700
Trp Thr Lys Ala Gln Asp Gly Ser Asn Pro Leu Ser Leu Gln Asp Leu 
 705                710                715                720
Ile Glu Lys Val Val Ile Leu Arg Lys Ala Val Gln Leu Thr Gln Ala 
                 725                730                735
Leu Asp Thr Asn Thr Val Gly Ala Leu Leu Ala Glu Lys Met Ser Gln 
             740                745                750
Tyr Ala Asn Leu Leu Ala Ala Gln Gly Ser Ile Ala Ala Ala Leu Ala 
         755                760                765
Phe Leu Pro Asp Asn Thr Asn Gln Pro Asp Ile Val Gln Leu Arg Asp 
     770                775                780
Arg Leu Cys Arg Ala Gln Gly Arg Ser Val Pro Gly Gln Glu Ser Ser 
 785                790                795                800
Arg Ser Ser Tyr Glu Gly Gln Pro Leu Pro Lys Gly Gly Pro Gly Pro 
                 805                810                815
Phe Ala Gly His Pro Gln Val Ser Arg Val Gln Ser Gln Gln Tyr Tyr 
             820                825                830
Pro Gln Val Arg Ile Ala Pro Thr Val Thr Thr Trp Ser Asp Arg Thr 
         835                840                845
Pro Thr Ala Leu Pro Ser His Pro Pro Ala Ala Cys Pro Ser Asp Thr 
     850                855                860
Gln Gly Gly Asn Pro Pro Pro Pro Gly Phe Ile Met His Gly Asn Val 
 865                870                875                880
Val Pro Asn Ser Pro Ala Pro Leu Pro Thr Ser Pro Gly His Met His 
                 885                890                895
Ser Gln Pro Pro Pro Tyr Pro Gln Pro Gln Pro Tyr Gln Pro Ala Gln 
             900                905                910
Gln Tyr Ser Leu Gly Thr Gly Gly Ser Ala Val Tyr Arg Pro Gln Gln 
         915                920                925
Pro Val Ala Pro Pro Ala Ser Lys Arg Tyr Pro Asn Ala Pro Tyr Val 
     930                935                940
Ser Pro Val Ala Ser Tyr Ser Gly Gln Pro His Met Tyr Thr Ala Gln 
 945                950                955                960
Pro Ala Ser Ser Pro Thr Ser Ser Ser Ala Pro Leu Pro Pro Pro Pro 
                 965                970                975
Ser Ser Gly Ala Ser Phe Gln His Gly Gly Pro Gly Ala Pro Pro Ser 
             980                985                990
Ser Ser Ala Tyr Ala Leu Pro Pro Gly Thr Thr Gly Thr Pro Pro Ala 
         995                1000                1005
Ala Ser Glu Leu Pro Ala Ser Gln Arg Thr Gly Pro Gln Asn Gly Trp 
     1010                1015                1020
Asn Asp Pro Pro Ala Leu Asn Arg Val Pro Lys Lys Lys Lys Leu Pro 
 1025                1030                1035                1040
Glu Asn Phe Met Pro Pro Val Pro Ile Thr Ser Pro Ile Met Asn Pro 
                 1045                1050                1055
Gly Gly Asp Pro Gln Pro Gln Gly Leu Gln Gln Gln Pro Ser Ala Ser 
             1060                1065                1070
Gly Pro Arg Ser Ser His Ala Ser Phe Pro Gln Pro His Leu Ala Gly 
         1075                1080                1085
Gly Gln Pro Phe His Gly Ile Gln Gln Pro Leu Ala Gln Thr Gly Met 
     1090                1095                1100
Pro Pro Ser Phe Ser Lys Pro Asn Thr Glu Gly Ala Pro Gly Ala Pro 
 1105                1110                1115                1120
Ile Gly Asn Thr Ile Gln His Val Gln Ala Leu Pro Thr Glu Lys Ile 
                 1125                1130                1135
Thr Lys Lys Pro Ile Pro Asp Glu His Leu Ile Leu Lys Thr Thr Phe 
             1140                1145                1150
Glu Asp Leu Ile Gln Arg Cys Leu Ser Ser Ala Thr Asp Pro Gln Thr 
         1155                1160                1165
Lys Arg Lys Leu Asp Asp Ala Ser Lys Arg Leu Glu Cys Leu Tyr Asp 
     1170                1175                1180
Lys Leu Arg Asp Gln Thr Leu Ser Pro Thr Ile Ile Ser Gly Leu His 
 1185                1190                1195                1200
Ser Ile Ala Arg Ser Ile Glu Thr Arg Asn Tyr Ser Glu Gly Leu Thr 
                 1205                1210                1215
Val His Thr His Ile Val Ser Thr Ser Asn Phe Ser Glu Thr Ser Ala 
             1220                1225                1230
Phe Met Pro Val Leu Lys Val Val Leu Ser Gln Ala Ser Lys Leu Gly 
         1235                1240                1245
Val 
     1250



<210> 720
<211> 4110
<212> DNA
<213> Homo sapiens
<308> AB020712
<400> 720

gcggaatag  gggttttgc  gcaaccggt  tattttcct  ctgttttca  ccattctgg  60
acaatctgg  gccatcgtc  ttcttgtga  gccaagcct  aaaatgcga  gcagagagg  120
aggaccaaa  ttgaggcga  tccaggaac  tgccaatgg  tctccgggt  cggtctctg  180
aactggagg  tatcgggag  aaaggctct  cgatgcgga  ataatgggg  agctcttgg  240
atggttggc  gtaggtatg  gataccgga  gagcaggag  caaatagga  acgccgact  300
ttaattcaa  gaacccttt  ctgaaacac  ttgccacaa  gaaggaaat  agattacag  360
cgaagatac  tattaagga  gaagttaaa  gaagtagat  gtacagcca  gcaggcatg  420
agccctgcc  agaatcacc  catttacct  gcaacagga  catctgctc  gcaattgga  480
gcaacattt  gtacgaatg  ttcccttga  atatttgaa  tagacctct  tgatccatc  540
ttggatatg  aatcttgtg  cacattctc  tcttctcac  ggtaccaca  gttgatttg  600
gggccttat  aaatggatt  caaaggaga  gtctctgga  ttctgattg  aggtggtga  660
aatggaaat  ttattctct  tgatccttc  aaaattata  ctggagaca  ggaagttgt  720
attgcccag  atgacaagc  tactggccc  gtgagagcc  tggatgtga  cattttcca  780
actaatctg  tagcttctg  tgctaatga  tctgaaatc  acatatggg  tctaaataa  840
tttgcaacc  caatgacac  aggagccaa  acacagccg  cagaagata  cagctgcat  900
gcatggaac  gacaagttc  gcatatttt  gcatcagcc  gtcccagtg  ccgggccac  960
gtatgggat  ttaggaaaa  tgagccaat  atcaaagtc  gtgaccata  taacagaat  1020
cattgttct  ggttggcat  gcatcctga  gttgctact  agatggtcc  tgcctccga  1080
gatgaccgg  taccagtga  ccagatgtg  gatcttcga  ttgcttcct  tccacttcg  1140
gtcctggaa  accatgcca  ggggatttt  gcaattgct  ggagcatgg  agatcctga  1200
ttgttactg  gctgtggaa  agatgctaa  attctctgc  ccaatccaa  cacaggaga  1260
gtgttatat  aacttccca  caacacaca  tggtgcttc  atattcagt  gtgtccccg  1320
aatcctgct  tcttatcag  tgcttcgtt  gatgggcgt  tcagtgttt  ttctatcat  1380
ggaggaagc  cagatggtt  aagacagaa  caagttgac  agctttcat  atcttttgg  1440
aatcttgat  cctttggca  aggacagcc  cttcctccg  tacaaattc  acagcagac  1500
gctcagcat  gtatagtgc  gcctctgaa  aagccgccc  agtggattc  aaggcctgt  1560
ggtgcttct  tttcatttg  aggcaaact  gttacgttt  agaatgtca  aatgccttc  1620
catcaggga  ctgagcagc  gcagcagca  caccatgtg  tcattagtc  ggttgtaac  1680
gaaaaggag  tcctcagcc  atcagacca  cttcagcag  ctgtgcagt  acaaggatt  1740
atcaattat  gccaaaaaa  aattgatgc  tctcagact  aatttgaga  aaatgtgtg  1800
tcctttttg  aggtaaact  tgaggatga  tctcgtgga  aataccttg  acttctagg  1860
tacagaaaa  aagatctag  aaagaagat  gctttggcc  tgaacaaag  ggatggagc  1920
aatgtggct  ttaaagact  tgaccaagt  gcacagagt  atggggagg  gagccctgc  1980
gctgaagag  agctcttgg  agagcacat  aaagaggaa  aagaagaat  tgaatttct  2040
ccctcatct  gaggaacat  taatatctc  gtcagtggg  acattgatg  tttaattac  2100
caggctttg  tgacgggca  ttttgagag  gctgttgac  tttgtttac  tgataaccg  2160
atggccgat  ccattatat  ggccatagc  ggtggacaa  aactcttgg  tcgaaccca  2220
aaaaaatac  tcgcaaaat  ccaaagcaa  attaccagg  tcatcactg  agtggtgat  2280
aagaactgg  aagagattg  tgagtcttg  gatcttaaa  attggagag  ggctttagc  2340
gcagtattg  cttatgcaa  gccggatga  ttttcagcc  tttgtgatc  tttgggaac  2400
aggcttgaa  atgaaggag  tagcctcct  cagactcaa  catgtctct  ctatatttg  2460
gcagggaat  tagagaaat  agttgcatg  tggactaaa  ctcaagatg  aagccaccc  2520
ttgtcactt  aggatctga  tgagaaagt  gtcatcctg  gaaaagctg  gcaactcac  2580
caagccatg  acactagta  tgtaggagt  ctcttggct  cgaagatga  tcagtatgc  2640
aatttgttg  cagctcagg  cagtattgc  gcagccttg  cttttcttc  tgacaacac  2700
aaccagcca  atatcatgc  gcttcgtga  agactttgt  gagcacaag  agagcctgt  2760
gcaggacat  aatcaccta  aattccgta  gagaaacag  agctcccca  gggcaggcc  2820
ggaccagtt  ctggccacc  ccagatgcc  agagttcaa  ctcaacaat  ttatcccca  2880
ggagaaaat  ctccacctc  gggtttcat  atgcatgga  atgttaatc  aaatgctgc  2940
ggtcagctt  ccacatctc  aggtcatat  cacacccag  taccacctt  tccacagcc  3000
cagccttat  aaccagccc  gccgtatcc  ttcggaaca  gggggtcag  aatgtatcg  3060
cctcagcag  ctgttgctc  tcctacttc  aacgcttac  ctaacaccc  ttacatatc  3120
tctgcttct  cctatactg  gcagtctca  ctgtacgca  cacagcacc  ggcctcttc  3180
cctacctcc  gccctgcta  ttctttccc  cctccccct  cctctggag  atccttcca  3240
catggcgga  caggagctc  accatcatc  tcagcttat  cactgcctc  tggaacaac  3300
ggtacactg  ctgctgcca  tgagctgcc  gcgtcccaa  gaacaggtc  tcagaatgg  3360
tggaatgac  ctccagctt  gaacagagt  cccaaaaag  agaagatgc  tgaaaactt  3420
atgcctcct  ttcccatca  atcaccaat  atgaacccg  tgggtgacc  ccagtcaca  3480
atgctgcag  aacagcctt  agctccagt  ccactgtca  gccagtctt  attcccaca  3540
ccacatctt  caggtggcc  gcccttcca  ggcgtacag  aacctcttg  tcaaacagg  3600
atgccacca  ctttttcaa  gcccaatat  gaaggtgcc  caggggctc  tattggaaa  3660
accttccag  atgtgcagt  tttgccaac  aaaaaaatt  ccaagaaac  tattccaga  3720
gagcacctc  ttctaaaga  cacatttga  gatcttatt  agcgctgcc  ttcttcagc  3780
acagaccct  aaaccaaga  gaagctaga  gatgccagc  aacgtttgg  gtttctgta  3840
gataaactt  gggaacaga  actttcacc  acaatcacc  gtggtttac  caacattgc  3900
aggagcatt  aaactcgaa  ctactcaga  ggattgacc  tgcataccc  catagttag  3960
accagcaac  tcagtgaga  ctctgcttt  atgccagtt  tcaaagttg  tctcaccca  4020
gccaataag  tgggtgtct  aaaggacag  ttctcttcc  ctcaatatt  ccatttttc  4080
aaagaaaca  gttaaaaaa  aaaaaaaaaa  4110



<210> 721
<211> 1220
<212> PRT
<213> Homo sapiens
<308> BAA74928
<400> 721

Met Lys Leu Lys Glu Val Asp Arg Thr Ala Met Gln Ala Trp Ser Pro 
  1               5                  10                  15
Ala Gln Asn His Pro Ile Tyr Leu Ala Thr Gly Thr Ser Ala Gln Gln 
             20                  25                  30
Leu Asp Ala Thr Phe Ser Thr Asn Ala Ser Leu Glu Ile Phe Glu Leu 
         35                  40                  45
Asp Leu Ser Asp Pro Ser Leu Asp Met Lys Ser Cys Ala Thr Phe Ser 
     50                  55                  60
Ser Ser His Arg Tyr His Lys Leu Ile Trp Gly Pro Tyr Lys Met Asp 
 65                  70                  75                  80
Ser Lys Gly Asp Val Ser Gly Val Leu Ile Ala Gly Gly Glu Asn Gly 
                 85                  90                  95
Asn Ile Ile Leu Tyr Asp Pro Ser Lys Ile Ile Ala Gly Asp Lys Glu 
             100                105                110
Val Val Ile Ala Gln Asn Asp Lys His Thr Gly Pro Val Arg Ala Leu 
         115                120                125
Asp Val Asn Ile Phe Gln Thr Asn Leu Val Ala Ser Gly Ala Asn Glu 
     130                135                140
Ser Glu Ile Tyr Ile Trp Asp Leu Asn Asn Phe Ala Thr Pro Met Thr 
 145                150                155                160
Pro Gly Ala Lys Thr Gln Pro Pro Glu Asp Ile Ser Cys Ile Ala Trp 
                 165                170                175
Asn Arg Gln Val Gln His Ile Leu Ala Ser Ala Ser Pro Ser Gly Arg 
             180                185                190
Ala Thr Val Trp Asp Leu Arg Lys Asn Glu Pro Ile Ile Lys Val Ser 
         195                200                205
Asp His Ser Asn Arg Met His Cys Ser Gly Leu Ala Trp His Pro Asp 
     210                215                220
Val Ala Thr Gln Met Val Leu Ala Ser Glu Asp Asp Arg Leu Pro Val 
 225                230                235                240
Ile Gln Met Trp Asp Leu Arg Phe Ala Ser Ser Pro Leu Arg Val Leu 
                 245                250                255
Glu Asn His Ala Arg Gly Ile Leu Ala Ile Ala Trp Ser Met Ala Asp 
             260                265                270
Pro Glu Leu Leu Leu Ser Cys Gly Lys Asp Ala Lys Ile Leu Cys Ser 
         275                280                285
Asn Pro Asn Thr Gly Glu Val Leu Tyr Glu Leu Pro Thr Asn Thr Gln 
     290                295                300
Trp Cys Phe Asp Ile Gln Trp Cys Pro Arg Asn Pro Ala Val Leu Ser 
 305                310                315                320
Ala Ala Ser Phe Asp Gly Arg Ile Ser Val Tyr Ser Ile Met Gly Gly 
                 325                330                335
Ser Thr Asp Gly Leu Arg Gln Lys Gln Val Asp Lys Leu Ser Ser Ser 
             340                345                350
Phe Gly Asn Leu Asp Pro Phe Gly Thr Gly Gln Pro Leu Pro Pro Leu 
         355                360                365
Gln Ile Pro Gln Gln Thr Ala Gln His Ser Ile Val Leu Pro Leu Lys 
     370                375                380
Lys Pro Pro Lys Trp Ile Arg Arg Pro Val Gly Ala Ser Phe Ser Phe 
 385                390                395                400
Gly Gly Lys Leu Val Thr Phe Glu Asn Val Arg Met Pro Ser His Gln 
                 405                410                415
Gly Ala Glu Gln Gln Gln Gln Gln His His Val Phe Ile Ser Gln Val 
             420                425                430
Val Thr Glu Lys Glu Phe Leu Ser Arg Ser Asp Gln Leu Gln Gln Ala 
         435                440                445
Val Gln Ser Gln Gly Phe Ile Asn Tyr Cys Gln Lys Lys Ile Asp Ala 
     450                455                460
Ser Gln Thr Glu Phe Glu Lys Asn Val Trp Ser Phe Leu Lys Val Asn 
 465                470                475                480
Phe Glu Asp Asp Ser Arg Gly Lys Tyr Leu Glu Leu Leu Gly Tyr Arg 
                 485                490                495
Lys Glu Asp Leu Gly Lys Lys Ile Ala Leu Ala Leu Asn Lys Val Asp 
             500                505                510
Gly Ala Asn Val Ala Leu Lys Asp Ser Asp Gln Val Ala Gln Ser Asp 
         515                520                525
Gly Glu Glu Ser Pro Ala Ala Glu Glu Gln Leu Leu Gly Glu His Ile 
     530                535                540
Lys Glu Glu Lys Glu Glu Ser Glu Phe Leu Pro Ser Ser Gly Gly Thr 
 545                550                555                560
Phe Asn Ile Ser Val Ser Gly Asp Ile Asp Gly Leu Ile Thr Gln Ala 
                 565                570                575
Leu Leu Thr Gly Asn Phe Glu Ser Ala Val Asp Leu Cys Leu His Asp 
             580                585                590
Asn Arg Met Ala Asp Ala Ile Ile Leu Ala Ile Ala Gly Gly Gln Glu 
         595                600                605
Leu Leu Ala Arg Thr Gln Lys Lys Tyr Phe Ala Lys Ser Gln Ser Lys 
     610                615                620
Ile Thr Arg Leu Ile Thr Ala Val Val Met Lys Asn Trp Lys Glu Ile 
 625                630                635                640
Val Glu Ser Cys Asp Leu Lys Asn Trp Arg Glu Ala Leu Ala Ala Val 
                 645                650                655
Leu Thr Tyr Ala Lys Pro Asp Glu Phe Ser Ala Leu Cys Asp Leu Leu 
             660                665                670
Gly Thr Arg Leu Glu Asn Glu Gly Asp Ser Leu Leu Gln Thr Gln Ala 
         675                680                685
Cys Leu Cys Tyr Ile Cys Ala Gly Asn Val Glu Lys Leu Val Ala Cys 
     690                695                700
Trp Thr Lys Ala Gln Asp Gly Ser His Pro Leu Ser Leu Gln Asp Leu 
 705                710                715                720
Ile Glu Lys Val Val Ile Leu Arg Lys Ala Val Gln Leu Thr Gln Ala 
                 725                730                735
Met Asp Thr Ser Thr Val Gly Val Leu Leu Ala Ala Lys Met Ser Gln 
             740                745                750
Tyr Ala Asn Leu Leu Ala Ala Gln Gly Ser Ile Ala Ala Ala Leu Ala 
         755                760                765
Phe Leu Pro Asp Asn Thr Asn Gln Pro Asn Ile Met Gln Leu Arg Asp 
     770                775                780
Arg Leu Cys Arg Ala Gln Gly Glu Pro Val Ala Gly His Glu Ser Pro 
 785                790                795                800
Lys Ile Pro Tyr Glu Lys Gln Gln Leu Pro Lys Gly Arg Pro Gly Pro 
                 805                810                815
Val Ala Gly His His Gln Met Pro Arg Val Gln Thr Gln Gln Tyr Tyr 
             820                825                830
Pro His Gly Glu Asn Pro Pro Pro Pro Gly Phe Ile Met His Gly Asn 
         835                840                845
Val Asn Pro Asn Ala Ala Gly Gln Leu Pro Thr Ser Pro Gly His Met 
     850                855                860
His Thr Gln Val Pro Pro Tyr Pro Gln Pro Gln Pro Tyr Gln Pro Ala 
 865                870                875                880
Gln Pro Tyr Pro Phe Gly Thr Gly Gly Ser Ala Met Tyr Arg Pro Gln 
                 885                890                895
Gln Pro Val Ala Pro Pro Thr Ser Asn Ala Tyr Pro Asn Thr Pro Tyr 
             900                905                910
Ile Ser Ser Ala Ser Ser Tyr Thr Gly Gln Ser Gln Leu Tyr Ala Ala 
         915                920                925
Gln His Gln Ala Ser Ser Pro Thr Ser Ser Pro Ala Thr Ser Phe Pro 
     930                935                940
Pro Pro Pro Ser Ser Gly Ala Ser Phe Gln His Gly Gly Pro Gly Ala 
 945                950                955                960
Pro Pro Ser Ser Ser Ala Tyr Ala Leu Pro Pro Gly Thr Thr Gly Thr 
                 965                970                975
Leu Pro Ala Ala Ser Glu Leu Pro Ala Ser Gln Arg Thr Gly Pro Gln 
             980                985                990
Asn Gly Trp Asn Asp Pro Pro Ala Leu Asn Arg Val Pro Lys Lys Lys 
         995                1000                1005
Lys Met Pro Glu Asn Phe Met Pro Pro Val Pro Ile Thr Ser Pro Ile 
     1010                1015                1020
Met Asn Pro Leu Gly Asp Pro Gln Ser Gln Met Leu Gln Gln Gln Pro 
 1025                1030                1035                1040
Ser Ala Pro Val Pro Leu Ser Ser Gln Ser Ser Phe Pro Gln Pro His 
                 1045                1050                1055
Leu Pro Gly Gly Gln Pro Phe His Gly Val Gln Gln Pro Leu Gly Gln 
             1060                1065                1070
Thr Gly Met Pro Pro Ser Phe Ser Lys Pro Asn Ile Glu Gly Ala Pro 
         1075                1080                1085
Gly Ala Pro Ile Gly Asn Thr Phe Gln His Val Gln Ser Leu Pro Thr 
     1090                1095                1100
Lys Lys Ile Thr Lys Lys Pro Ile Pro Asp Glu His Leu Ile Leu Lys 
 1105                1110                1115                1120
Thr Thr Phe Glu Asp Leu Ile Gln Arg Cys Leu Ser Ser Ala Thr Asp 
                 1125                1130                1135
Pro Gln Thr Lys Arg Lys Leu Asp Asp Ala Ser Lys Arg Leu Glu Phe 
             1140                1145                1150
Leu Tyr Asp Lys Leu Arg Glu Gln Thr Leu Ser Pro Thr Ile Thr Ser 
         1155                1160                1165
Gly Leu His Asn Ile Ala Arg Ser Ile Glu Thr Arg Asn Tyr Ser Glu 
     1170                1175                1180
Gly Leu Thr Met His Thr His Ile Val Ser Thr Ser Asn Phe Ser Glu 
 1185                1190                1195                1200
Thr Ser Ala Phe Met Pro Val Leu Lys Val Val Leu Thr Gln Ala Asn 
                 1205                1210                1215
Lys Leu Gly Val 
             1220



<210> 722
<211> 2896
<212> DNA
<213> Rattus norvegicus
<308> AF034899
<400> 722

cgcttctat  tgtctggaa  accctttga  atgtagacc  ctatgtgtc  acaagacag  60
acttgaaac  atccttctc  tttcccggg  tcatttgtg  aaatagaac  ttcgggttt  120
aatcacaaa  agaattcca  tacattgat  ttggtacat  ctgaggatg  actcgacat  180
tgatggaga  ctaaaagca  tagaaaatt  aggcagatt  tgcctcttt  aacataatt  240
caaataata  ggagggaaa  ttgtactga  ttcaaattt  tcacttcat  ttgtgtgat  300
tagtatttt  ttaatatct  aacaaatag  atttgtatt  gataatagt  ttttaaagt  360
gagacctgg  tgatgttcc  atttttatt  gactctgaa  tttggaagg  atgaaatac  420
cttatgaca  gctttattt  ttaatttga  ctacaaata  taaaagtat  aaatgaaaa  480
atatgcaca  gctgttctg  tgccagtat  trctgtcat  agttcctcc  caaggactg  540
ctccatttg  ccctgtctc  tgggtgctc  tcaatattg  aaacgtttg  attgggctg  600
tggagataa  tgggataag  ctatataca  aggacattt  tttttaagt  accagttaa  660
ccctactca  atattcctt  ttatggcta  atttctccc  tgacttcta  atctatgtg  720
ctgaggaaa  tgtgtagct  cttccagat  ggaaaatat  caacaggta  acacagacc  780
gtataatta  ctgacaaaa  tctataaac  ccaaaaaaa  tatgtcaga  aagaagtca  840
gactcaata  gaaaatatt  agttgaaaa  ggtatgtac  aaatgagag  atgtcgaaa  900
agagagaga  agagagaga  agagagaga  agagagaga  agagagaga  tggttaaag  960
gagcaagtg  taacaggaa  gaggaaaca  aatgaatgt  aaaggacct  ctcatcctc  1020
cattgacag  tgactaaag  gaacctgaa  ggacaactg  ccatcactt  acctgttgt  1080
atcgttagc  caatatctc  ctgtaacct  ggctgtcat  taactcaca  cgaccttct  1140
cctctgcta  acaatgctt  ggagtaaag  atacaccag  ttccctgtt  atattttgt  1200
atttaatgg  tgacaagta  gaatatact  taaaaagaa  catctagta  tctgaatag  1260
gaaagaatt  atttaaaaa  aatttcgag  tgagtgttg  tttcggaat  tttttttta  1320
aaatttaaa  attcttcaa  taacaaatt  cgaatttac  caaaactct  gaattagta  1380
aatgatgtg  tatagaaat  gttcagtag  tggtagact  gttgttcag  tatgaggaa  1440
ggagtttgg  cccatagta  ccaggaaag  ctgagccaa  caacattta  ataattcca  1500
cactacagg  atgaaaggc  aaagaaggt  gattcctga  gcagtctag  aaaaacaag  1560
accttcagg  caagtaact  acgctgttt  aggaaataa  gcagacact  tagggtctt  1620
aaatcactt  aaattgata  ttgaacatt  taagcacat  tatgtccat  tattgatta  1680
acacacaca  acacacaca  gagagggag  gagagaaac  tggagagaa  gagacagat  1740
gagagatag  ctgaataat  tccctaatc  gcaagaatt  ttgtaayra  tttgtcctt  1800
ctttcagga  atgactgtc  actgttctc  gtggcagga  aatagtttg  ctgtcaaac  1860
ttttgcatt  gccaagttc  ctgaggtcc  tggagaatg  ttcctcctg  tcaccctca  1920
ccttctcat  ttcttagta  cactaacag  aaatgctct  atagccctt  ctatttgta  1980
cagtccatc  ctacacacc  ccatgtact  ctttctggc  aacttgtct  tcctggaga  2040
tggctatac  tgctctgtc  tacccaaga  gctgcagag  cttgtgagt  aggcccgag  2100
gatctttca  gtgggatgt  ccacacaga  gtttttctt  atattcttt  gtataactg  2160
gtgctgcct  ttggcagcc  tggcctttg  ccgctatat  gctatatgt  ccccactcc  2220
ctatgcaac  cgaatgagt  gtgaggtat  tgcccactt  gcaattgtt  catgggtga  2280
gggatgcat  gtaggtctg  gacagacca  ttttatttt  tccttgaac  tctgtggac  2340
ctgtgagat  gaccacttc  tctgtgatc  tccacctct  ctggcactt  cctgtggtg  2400
tacatccca  attgaggct  ccatctttg  ggtagttgt  ctctgcata  ctagccctt  2460
tttgctgat  atttattct  atgtcagaa  tctcgttgc  gtgctggtg  tgccttcac  2520
tgaggggcg  cacaaagcc  tttcaacct  ttcctccca  ctacttgta  tcacactct  2580
ttatggctc  ggatctgtt  cctatttga  gcctaagtc  agccactca  caggaatgg  2640
caaactctt  gccctcttc  acacagcag  gacatccat  ttgaaccct  tcatctata  2700
tttaaggaa  aaggatgtc  aggcagcac  gagaagaat  ctggccctg  aaaaaattc  2760
gtcaataaa  aagtaacag  atcatgcaa  gctggtatt  ataaaaatg  gcaaagagc  2820
agattaaac  aagaaaaat  ggtacattc  tttgtctgc  ttatattga  tctctttgt  2880
atttcgaag  tacctc  2896



<210> 723
<211> 322
<212> PRT
<213> Rattus norvegicus
<308> AF034899
<400> 723

Met Thr Val Asn Cys Ser Leu Trp Gln Glu Asn Ser Leu Ser Val Lys 
  1               5                  10                  15
Arg Phe Ala Phe Ala Lys Phe Ser Glu Val Pro Gly Glu Cys Phe Leu 
             20                  25                  30
Leu Phe Thr Leu Ile Leu Leu Met Phe Leu Val Ser Leu Thr Gly Asn 
         35                  40                  45
Ala Leu Ile Ala Leu Ala Ile Cys Thr Ser Pro Ser Leu His Thr Pro 
     50                  55                  60
Met Tyr Phe Phe Leu Ala Asn Leu Ser Leu Leu Glu Ile Gly Tyr Thr 
 65                  70                  75                  80
Cys Ser Val Ile Pro Lys Met Leu Gln Ser Leu Val Ser Glu Ala Arg 
                 85                  90                  95
Glu Ile Phe Gln Val Gly Cys Ala Thr Gln Met Phe Phe Phe Ile Phe 
             100                105                110
Phe Gly Ile Thr Glu Cys Cys Leu Leu Ala Ala Met Ala Phe Asp Arg 
         115                120                125
Tyr Met Ala Ile Cys Ser Pro Leu His Tyr Ala Thr Arg Met Ser Arg 
     130                135                140
Glu Val Cys Ala His Leu Ala Ile Val Ser Trp Val Met Gly Cys Ile 
 145                150                155                160
Val Gly Leu Gly Gln Thr Asn Phe Ile Phe Ser Leu Asn Phe Cys Gly 
                 165                170                175
Pro Cys Glu Ile Asp His Phe Phe Cys Asp Leu Pro Pro Leu Leu Ala 
             180                185                190
Leu Ala Cys Gly Asp Thr Ser Gln Ile Glu Ala Ala Ile Phe Val Val 
         195                200                205
Val Val Leu Cys Ile Ser Ser Pro Phe Leu Leu Ile Ile Tyr Ser Tyr 
     210                215                220
Val Arg Ile Leu Val Ala Val Leu Val Met Pro Ser Pro Glu Gly Arg 
 225                230                235                240
His Lys Ala Leu Ser Thr Cys Ser Ser His Leu Leu Val Val Thr Leu 
                 245                250                255
Phe Tyr Gly Ser Gly Ser Val Thr Tyr Leu Arg Pro Lys Ser Ser His 
             260                265                270
Ser Pro Gly Met Asp Lys Leu Leu Ala Leu Phe Tyr Thr Ala Val Thr 
         275                280                285
Ser Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
     290                295                300
Ala Ala Leu Arg Arg Ile Leu Ala Leu Lys Lys Ile Leu Ser Ile Asn 
 305                310                315                320
Lys Ter 
                 325



<210> 724
<211> 1990
<212> DNA
<213> Homo sapiens
<308> L35475
<400> 724

tttacagag  tctataaaa  tcattcaac  aatagagca  taattgagc  tacagagac  60
acttatcag  aaattcatt  aatatacct  acgagatca  ccaatagat  agagacaac  120
ctagaacag  attcagaac  tagtggcac  caataaatt  cccctgaat  aatgaatta  180
tgaattagt  catatttta  tcagcctcc  ttgccctca  ccaggaagt  agaggcacc  240
gtgtgagta  ccatctgct  tccagtaca  tcatggatt  ctcactctc  ctagacaat  300
tttgaccag  aagaacagg  aatgagaag  agctgctgg  tggtgatga  ccttggaaa  360
ggaggctgg  cgagcagag  cagaagaga  acacctacc  gctgtgacc  cacaaacac  420
caggctgag  tttgataag  caggttgaa  cacactggg  tgacagcct  atccctcca  480
gtacaaaca  gaacaggcc  tggataacc  aagctccac  ccgggcttc  tccttctgg  540
cttctctga  cacccaggg  tgggaagga  tctcttcgt  gatgtcatc  cttcctacc  600
cctaaccct  gtgggcaac  cactcatca  cctgctgtc  gcgctggac  ccaagctcc  660
ctctccaat  tactttttc  tctccaacc  ctccttctt  gacctctgt  tcaccacga  720
ttgtgttcc  caaatgctg  ccaacctct  gggcccaaa  aagaccatc  gcttcctgg  780
ctgctctgt  cagatcttc  tcttcctgt  cctggggac  actgagtgc  tcctcatga  840
agtgatggc  tttgatcgc  acgtggctg  ctgccagcc  ctccactat  ccaccatca  900
ccacccccg  ctgtgctgg  agctggcat  tgtggcctg  gtcattggg  tagtggggt  960
agtggtcca  acaccatcc  ccctgcacc  gcccttctg  cccgatcgg  aggtggatg  1020
ttttgtctg  gaggtccca  ctctaattc  actctcctg  gaagacacc  cctacaatg  1080
gatccaggt  gctgttgcc  gtgtcttca  cttggttgt  cctctcagc  tcatccttg  1140
ctcttacgg  gccattacc  gggcagtgc  gaggattaa  tccgccaca  catggagaa  1200
ggcctttgg  acctgctcc  cccatctca  tgtggtcac  ctcttctac  gctcagtca  1260
tgctgtcta  ctccagccc  aaaatccgt  tgcccaagg  aggggcaag  tctttggtc  1320
cttctatgc  gtgggcact  cttcactta  ccctctcgt  tacaccctg  ggaacaagg  1380
gataaagcg  gcactcagg  ggttactag  gaaggaaag  gactccagg  aaagctgga  1440
agctgctta  tatactttc  aaagtaaga  gagtttctt  aagatttat  aacatgtta  1500
gttttccag  ctactaccc  tcccacata  aacctggag  cactgtggg  gggtcacag  1560
gtgggtatg  tatctatga  agggagaat  agaaagaga  ggacagaga  ataaaagaa  1620
ttgggtgag  ggagatagg  agctccata  ggcacacaa  ttcagatat  atcattcct  1680
tcactgtcc  tccttaata  ttctatcct  cattctgtc  tatttactg  catcactcc  1740
atagattcc  taactccac  atgcctatc  ctggttata  aattgctct  caatggtca  1800
gtcagtgta  gggaactac  ccatcatag  attctggac  cctcgcatg  atctacgta  1860
gtcatgtca  cacaggctt  aaggaacag  tactctgag  tttaggaag  atgcttctg  1920
gatcccccc  cggcaatat  agaggatcg  gaggcccct  caggaacct  cctcaaatg  1980
caccttctca  1990



<210> 725
<211> 316
<212> PRT
<213> Homo sapiens
<308> Q15062
<400> 725

Met Asp Asn Gln Ser Ser Thr Pro Gly Phe Leu Leu Leu Gly Phe Ser 
  1               5                  10                  15
Glu His Pro Gly Leu Glu Arg Thr Leu Phe Val Val Val Phe Thr Ser 
             20                  25                  30
Tyr Leu Leu Thr Leu Val Gly Asn Thr Leu Ile Ile Leu Leu Ser Ala 
         35                  40                  45
Leu Asp Pro Lys Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asn Leu 
     50                  55                  60
Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Cys Val Pro Gln Met Leu 
 65                  70                  75                  80
Val Asn Leu Trp Gly Pro Lys Lys Thr Ile Ser Phe Leu Asp Cys Ser 
                 85                  90                  95
Val Gln Ile Phe Ile Phe Leu Ser Leu Gly Thr Thr Glu Cys Ile Leu 
             100                105                110
Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 
         115                120                125
His Tyr Ala Thr Ile Ile His Pro Arg Leu Cys Trp Gln Leu Ala Ser 
     130                135                140
Val Ala Trp Val Ile Gly Leu Val Glu Ser Val Val Gln Thr Pro Ser 
 145                150                155                160
Thr Leu His Leu Pro Phe Cys Pro Asp Arg Gln Val Asp Asp Phe Val 
                 165                170                175
Cys Glu Val Pro Ala Leu Ile Arg Leu Ser Cys Glu Asp Thr Ser Tyr 
             180                185                190
Asn Glu Ile Gln Val Ala Val Ala Ser Val Phe Ile Leu Val Val Pro 
         195                200                205
Leu Ser Leu Ile Leu Val Ser Tyr Gly Ala Ile Thr Trp Ala Val Leu 
     210                215                220
Arg Ile Asn Ser Ala Lys Gly Arg Arg Lys Ala Phe Gly Thr Cys Ser 
 225                230                235                240
Ser His Leu Thr Val Val Thr Leu Phe Tyr Ser Ser Val Ile Ala Val 
                 245                250                255
Tyr Leu Gln Pro Lys Asn Pro Tyr Ala Gln Glu Arg Gly Lys Phe Phe 
             260                265                270
Gly Leu Phe Tyr Ala Val Gly Thr Pro Ser Leu Asn Pro Leu Ile Tyr 
         275                280                285
Thr Leu Arg Asn Lys Glu Val Thr Arg Ala Phe Arg Arg Leu Leu Gly 
     290                295                300
Lys Glu Arg Asp Ser Arg Glu Ser Trp Arg Ala Ala 
 305                310                315



<210> 726
<211> 2896
<212> DNA
<213> Rattus norvegicus
<308> AF034899
<400> 726

cgcttctat  tgtctggaa  accctttga  atgtagacc  ctatgtgtc  acaagacag  60
acttgaaac  atccttctc  tttcccggg  tcatttgtg  aaatagaac  ttcgggttt  120
aatcacaaa  agaattcca  tacattgat  ttggtacat  ctgaggatg  actcgacat  180
tgatggaga  ctaaaagca  tagaaaatt  aggcagatt  tgcctcttt  aacataatt  240
caaataata  ggagggaaa  ttgtactga  ttcaaattt  tcacttcat  ttgtgtgat  300
tagtatttt  ttaatatct  aacaaatag  atttgtatt  gataatagt  ttttaaagt  360
gagacctgg  tgatgttcc  atttttatt  gactctgaa  tttggaagg  atgaaatac  420
cttatgaca  gctttattt  ttaatttga  ctacaaata  taaaagtat  aaatgaaaa  480
atatgcaca  gctgttctg  tgccagtat  trctgtcat  agttcctcc  caaggactg  540
ctccatttg  ccctgtctc  tgggtgctc  tcaatattg  aaacgtttg  attgggctg  600
tggagataa  tgggataag  ctatataca  aggacattt  tttttaagt  accagttaa  660
ccctactca  atattcctt  ttatggcta  atttctccc  tgacttcta  atctatgtg  720
ctgaggaaa  tgtgtagct  cttccagat  ggaaaatat  caacaggta  acacagacc  780
gtataatta  ctgacaaaa  tctataaac  ccaaaaaaa  tatgtcaga  aagaagtca  840
gactcaata  gaaaatatt  agttgaaaa  ggtatgtac  aaatgagag  atgtcgaaa  900
agagagaga  agagagaga  agagagaga  agagagaga  agagagaga  tggttaaag  960
gagcaagtg  taacaggaa  gaggaaaca  aatgaatgt  aaaggacct  ctcatcctc  1020
cattgacag  tgactaaag  gaacctgaa  ggacaactg  ccatcactt  acctgttgt  1080
atcgttagc  caatatctc  ctgtaacct  ggctgtcat  taactcaca  cgaccttct  1140
cctctgcta  acaatgctt  ggagtaaag  atacaccag  ttccctgtt  atattttgt  1200
atttaatgg  tgacaagta  gaatatact  taaaaagaa  catctagta  tctgaatag  1260
gaaagaatt  atttaaaaa  aatttcgag  tgagtgttg  tttcggaat  tttttttta  1320
aaatttaaa  attcttcaa  taacaaatt  cgaatttac  caaaactct  gaattagta  1380
aatgatgtg  tatagaaat  gttcagtag  tggtagact  gttgttcag  tatgaggaa  1440
ggagtttgg  cccatagta  ccaggaaag  ctgagccaa  caacattta  ataattcca  1500
cactacagg  atgaaaggc  aaagaaggt  gattcctga  gcagtctag  aaaaacaag  1560
accttcagg  caagtaact  acgctgttt  aggaaataa  gcagacact  tagggtctt  1620
aaatcactt  aaattgata  ttgaacatt  taagcacat  tatgtccat  tattgatta  1680
acacacaca  acacacaca  gagagggag  gagagaaac  tggagagaa  gagacagat  1740
gagagatag  ctgaataat  tccctaatc  gcaagaatt  ttgtaayra  tttgtcctt  1800
ctttcagga  atgactgtc  actgttctc  gtggcagga  aatagtttg  ctgtcaaac  1860
ttttgcatt  gccaagttc  ctgaggtcc  tggagaatg  ttcctcctg  tcaccctca  1920
ccttctcat  ttcttagta  cactaacag  aaatgctct  atagccctt  ctatttgta  1980
cagtccatc  ctacacacc  ccatgtact  ctttctggc  aacttgtct  tcctggaga  2040
tggctatac  tgctctgtc  tacccaaga  gctgcagag  cttgtgagt  aggcccgag  2100
gatctttca  gtgggatgt  ccacacaga  gtttttctt  atattcttt  gtataactg  2160
gtgctgcct  ttggcagcc  tggcctttg  ccgctatat  gctatatgt  ccccactcc  2220
ctatgcaac  cgaatgagt  gtgaggtat  tgcccactt  gcaattgtt  catgggtga  2280
gggatgcat  gtaggtctg  gacagacca  ttttatttt  tccttgaac  tctgtggac  2340
ctgtgagat  gaccacttc  tctgtgatc  tccacctct  ctggcactt  cctgtggtg  2400
tacatccca  attgaggct  ccatctttg  ggtagttgt  ctctgcata  ctagccctt  2460
tttgctgat  atttattct  atgtcagaa  tctcgttgc  gtgctggtg  tgccttcac  2520
tgaggggcg  cacaaagcc  tttcaacct  ttcctccca  ctacttgta  tcacactct  2580
ttatggctc  ggatctgtt  cctatttga  gcctaagtc  agccactca  caggaatgg  2640
caaactctt  gccctcttc  acacagcag  gacatccat  ttgaaccct  tcatctata  2700
tttaaggaa  aaggatgtc  aggcagcac  gagaagaat  ctggccctg  aaaaaattc  2760
gtcaataaa  aagtaacag  atcatgcaa  gctggtatt  ataaaaatg  gcaaagagc  2820
agattaaac  aagaaaaat  ggtacattc  tttgtctgc  ttatattga  tctctttgt  2880
atttcgaag  tacctc  2896



<210> 727
<211> 322
<212> PRT
<213> Rattus norvegicus
<308> AF034899
<400> 727

Met Thr Val Asn Cys Ser Leu Trp Gln Glu Asn Ser Leu Ser Val Lys 
  1               5                  10                  15
Arg Phe Ala Phe Ala Lys Phe Ser Glu Val Pro Gly Glu Cys Phe Leu 
             20                  25                  30
Leu Phe Thr Leu Ile Leu Leu Met Phe Leu Val Ser Leu Thr Gly Asn 
         35                  40                  45
Ala Leu Ile Ala Leu Ala Ile Cys Thr Ser Pro Ser Leu His Thr Pro 
     50                  55                  60
Met Tyr Phe Phe Leu Ala Asn Leu Ser Leu Leu Glu Ile Gly Tyr Thr 
 65                  70                  75                  80
Cys Ser Val Ile Pro Lys Met Leu Gln Ser Leu Val Ser Glu Ala Arg 
                 85                  90                  95
Glu Ile Phe Gln Val Gly Cys Ala Thr Gln Met Phe Phe Phe Ile Phe 
             100                105                110
Phe Gly Ile Thr Glu Cys Cys Leu Leu Ala Ala Met Ala Phe Asp Arg 
         115                120                125
Tyr Met Ala Ile Cys Ser Pro Leu His Tyr Ala Thr Arg Met Ser Arg 
     130                135                140
Glu Val Cys Ala His Leu Ala Ile Val Ser Trp Val Met Gly Cys Ile 
 145                150                155                160
Val Gly Leu Gly Gln Thr Asn Phe Ile Phe Ser Leu Asn Phe Cys Gly 
                 165                170                175
Pro Cys Glu Ile Asp His Phe Phe Cys Asp Leu Pro Pro Leu Leu Ala 
             180                185                190
Leu Ala Cys Gly Asp Thr Ser Gln Ile Glu Ala Ala Ile Phe Val Val 
         195                200                205
Val Val Leu Cys Ile Ser Ser Pro Phe Leu Leu Ile Ile Tyr Ser Tyr 
     210                215                220
Val Arg Ile Leu Val Ala Val Leu Val Met Pro Ser Pro Glu Gly Arg 
 225                230                235                240
His Lys Ala Leu Ser Thr Cys Ser Ser His Leu Leu Val Val Thr Leu 
                 245                250                255
Phe Tyr Gly Ser Gly Ser Val Thr Tyr Leu Arg Pro Lys Ser Ser His 
             260                265                270
Ser Pro Gly Met Asp Lys Leu Leu Ala Leu Phe Tyr Thr Ala Val Thr 
         275                280                285
Ser Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
     290                295                300
Ala Ala Leu Arg Arg Ile Leu Ala Leu Lys Lys Ile Leu Ser Ile Asn 
 305                310                315                320
Lys Ter 
                 325



<210> 728
<211> 1990
<212> DNA
<213> Homo sapiens
<308> L35475
<400> 728

tttacagag  tctataaaa  tcattcaac  aatagagca  taattgagc  tacagagac  60
acttatcag  aaattcatt  aatatacct  acgagatca  ccaatagat  agagacaac  120
ctagaacag  attcagaac  tagtggcac  caataaatt  cccctgaat  aatgaatta  180
tgaattagt  catatttta  tcagcctcc  ttgccctca  ccaggaagt  agaggcacc  240
gtgtgagta  ccatctgct  tccagtaca  tcatggatt  ctcactctc  ctagacaat  300
tttgaccag  aagaacagg  aatgagaag  agctgctgg  tggtgatga  ccttggaaa  360
ggaggctgg  cgagcagag  cagaagaga  acacctacc  gctgtgacc  cacaaacac  420
caggctgag  tttgataag  caggttgaa  cacactggg  tgacagcct  atccctcca  480
gtacaaaca  gaacaggcc  tggataacc  aagctccac  ccgggcttc  tccttctgg  540
cttctctga  cacccaggg  tgggaagga  tctcttcgt  gatgtcatc  cttcctacc  600
cctaaccct  gtgggcaac  cactcatca  cctgctgtc  gcgctggac  ccaagctcc  660
ctctccaat  tactttttc  tctccaacc  ctccttctt  gacctctgt  tcaccacga  720
ttgtgttcc  caaatgctg  ccaacctct  gggcccaaa  aagaccatc  gcttcctgg  780
ctgctctgt  cagatcttc  tcttcctgt  cctggggac  actgagtgc  tcctcatga  840
agtgatggc  tttgatcgc  acgtggctg  ctgccagcc  ctccactat  ccaccatca  900
ccacccccg  ctgtgctgg  agctggcat  tgtggcctg  gtcattggg  tagtggggt  960
agtggtcca  acaccatcc  ccctgcacc  gcccttctg  cccgatcgg  aggtggatg  1020
ttttgtctg  gaggtccca  ctctaattc  actctcctg  gaagacacc  cctacaatg  1080
gatccaggt  gctgttgcc  gtgtcttca  cttggttgt  cctctcagc  tcatccttg  1140
ctcttacgg  gccattacc  gggcagtgc  gaggattaa  tccgccaca  catggagaa  1200
ggcctttgg  acctgctcc  cccatctca  tgtggtcac  ctcttctac  gctcagtca  1260
tgctgtcta  ctccagccc  aaaatccgt  tgcccaagg  aggggcaag  tctttggtc  1320
cttctatgc  gtgggcact  cttcactta  ccctctcgt  tacaccctg  ggaacaagg  1380
gataaagcg  gcactcagg  ggttactag  gaaggaaag  gactccagg  aaagctgga  1440
agctgctta  tatactttc  aaagtaaga  gagtttctt  aagatttat  aacatgtta  1500
gttttccag  ctactaccc  tcccacata  aacctggag  cactgtggg  gggtcacag  1560
gtgggtatg  tatctatga  agggagaat  agaaagaga  ggacagaga  ataaaagaa  1620
ttgggtgag  ggagatagg  agctccata  ggcacacaa  ttcagatat  atcattcct  1680
tcactgtcc  tccttaata  ttctatcct  cattctgtc  tatttactg  catcactcc  1740
atagattcc  taactccac  atgcctatc  ctggttata  aattgctct  caatggtca  1800
gtcagtgta  gggaactac  ccatcatag  attctggac  cctcgcatg  atctacgta  1860
gtcatgtca  cacaggctt  aaggaacag  tactctgag  tttaggaag  atgcttctg  1920
gatcccccc  cggcaatat  agaggatcg  gaggcccct  caggaacct  cctcaaatg  1980
caccttctca  1990



<210> 729
<211> 316
<212> PRT
<213> Homo sapiens
<308> Q15062
<400> 729

Met Asp Asn Gln Ser Ser Thr Pro Gly Phe Leu Leu Leu Gly Phe Ser 
  1               5                  10                  15
Glu His Pro Gly Leu Glu Arg Thr Leu Phe Val Val Val Phe Thr Ser 
             20                  25                  30
Tyr Leu Leu Thr Leu Val Gly Asn Thr Leu Ile Ile Leu Leu Ser Ala 
         35                  40                  45
Leu Asp Pro Lys Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asn Leu 
     50                  55                  60
Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Cys Val Pro Gln Met Leu 
 65                  70                  75                  80
Val Asn Leu Trp Gly Pro Lys Lys Thr Ile Ser Phe Leu Asp Cys Ser 
                 85                  90                  95
Val Gln Ile Phe Ile Phe Leu Ser Leu Gly Thr Thr Glu Cys Ile Leu 
             100                105                110
Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 
         115                120                125
His Tyr Ala Thr Ile Ile His Pro Arg Leu Cys Trp Gln Leu Ala Ser 
     130                135                140
Val Ala Trp Val Ile Gly Leu Val Glu Ser Val Val Gln Thr Pro Ser 
 145                150                155                160
Thr Leu His Leu Pro Phe Cys Pro Asp Arg Gln Val Asp Asp Phe Val 
                 165                170                175
Cys Glu Val Pro Ala Leu Ile Arg Leu Ser Cys Glu Asp Thr Ser Tyr 
             180                185                190
Asn Glu Ile Gln Val Ala Val Ala Ser Val Phe Ile Leu Val Val Pro 
         195                200                205
Leu Ser Leu Ile Leu Val Ser Tyr Gly Ala Ile Thr Trp Ala Val Leu 
     210                215                220
Arg Ile Asn Ser Ala Lys Gly Arg Arg Lys Ala Phe Gly Thr Cys Ser 
 225                230                235                240
Ser His Leu Thr Val Val Thr Leu Phe Tyr Ser Ser Val Ile Ala Val 
                 245                250                255
Tyr Leu Gln Pro Lys Asn Pro Tyr Ala Gln Glu Arg Gly Lys Phe Phe 
             260                265                270
Gly Leu Phe Tyr Ala Val Gly Thr Pro Ser Leu Asn Pro Leu Ile Tyr 
         275                280                285
Thr Leu Arg Asn Lys Glu Val Thr Arg Ala Phe Arg Arg Leu Leu Gly 
     290                295                300
Lys Glu Arg Asp Ser Arg Glu Ser Trp Arg Ala Ala 
 305                310                315



<210> 730
<211> 966
<212> DNA
<213> Rattus norvegicus
<308> AF034900
<400> 730

atgagtgtc  actgttcgc  gtggcagga  aatagtttg  ctgtcaaac  ctttgcatt  60
gccaagttc  ctgaggtcc  tggagaatg  ttcctcctg  tcaccctca  ccttctcat  120
ttcttagta  cactaacag  aaatgctct  atagccctt  ctgtttgta  cagtccatc  180
ctacacacc  ccatgtact  ctttctggc  aacttgtct  tcctggaga  tggctatac  240
tgctctgtc  tacccaaga  gctgcagag  cttgtgagt  aggccagag  gatctctag  300
gagggatgt  ccacacaga  gtttttctt  acatttttt  gcataactg  gtgctgcct  360
ttggcagcc  tggcctttg  ccgctgcat  ggcatatgc  ccccactcc  ctatgcaac  420
cgaatgagt  gtgaggtat  tgcccattt  gcaattgtt  catggggaa  gggatgcat  480
gtaggtctg  gacagacca  ttttatttt  tccttgaac  tctgtggac  ttgtgagat  540
gaccacttc  tctgtgacc  tccacctct  ctggcactt  cctgtggtg  tacatccca  600
aacgaggct  ccatctttg  ggcagcaat  ctctgtata  ctagtccat  tttggtgat  660
ctttattct  atgtcagaa  tctcgttgc  gtgctggtg  tgccttcac  tgaggggcg  720
cataaagct  tttccacct  ttcctcaca  ctacttgta  tcacactct  ttatggctc  780
gtgtccttt  cctatttga  gcccaagtc  agccactca  caggaatgg  caaactctt  840
gccctcttc  acacagcag  gacatccat  ctgaaccct  tcatctaca  tctaaggaa  900
aaggaagtc  aggcagcac  gagaagaac  ctcgacctg  aaaaaatta  gtcaattaa  960
aggtaa  966



<210> 731
<211> 321
<212> PRT
<213> Rattus norvegicus
<308> AAC17224
<400> 731

Met Ser Val Asn Cys Ser Leu Trp Gln Glu Asn Ser Leu Ser Val Lys 
  1               5                  10                  15
Arg Phe Ala Phe Ala Lys Phe Ser Glu Val Pro Gly Glu Cys Phe Leu 
             20                  25                  30
Leu Phe Thr Leu Ile Leu Leu Met Phe Leu Val Ser Leu Thr Gly Asn 
         35                  40                  45
Ala Leu Ile Ala Leu Ala Val Cys Thr Ser Pro Ser Leu His Thr Pro 
     50                  55                  60
Met Tyr Phe Phe Leu Ala Asn Leu Ser Leu Leu Glu Ile Gly Tyr Thr 
 65                  70                  75                  80
Cys Ser Val Ile Pro Lys Met Leu Gln Ser Leu Val Ser Glu Ala Arg 
                 85                  90                  95
Glu Ile Ser Arg Glu Gly Cys Ala Thr Gln Met Phe Phe Phe Thr Phe 
             100                105                110
Phe Gly Ile Thr Glu Cys Cys Leu Leu Ala Ala Met Ala Phe Asp Arg 
         115                120                125
Cys Met Gly Ile Cys Ser Pro Leu His Tyr Ala Thr Arg Met Ser Arg 
     130                135                140
Glu Val Cys Ala His Leu Ala Ile Val Ser Trp Gly Met Gly Cys Ile 
 145                150                155                160
Val Gly Leu Gly Gln Thr Asn Phe Ile Phe Ser Leu Asn Phe Cys Gly 
                 165                170                175
Pro Cys Glu Ile Asp His Phe Phe Cys Asp Leu Pro Pro Leu Leu Ala 
             180                185                190
Leu Ala Cys Gly Asp Thr Ser Gln Asn Glu Ala Ala Ile Phe Val Ala 
         195                200                205
Ala Ile Leu Cys Ile Ser Ser Pro Phe Leu Val Ile Leu Tyr Ser Tyr 
     210                215                220
Val Arg Ile Leu Val Ala Val Leu Val Met Pro Ser Pro Glu Gly Arg 
 225                230                235                240
His Lys Ala Leu Ser Thr Cys Ser Ser His Leu Leu Val Val Thr Leu 
                 245                250                255
Phe Tyr Gly Ser Val Ser Phe Thr Tyr Leu Arg Pro Lys Ser Ser His 
             260                265                270
Ser Pro Gly Met Asp Lys Leu Leu Ala Leu Phe Tyr Thr Ala Val Thr 
         275                280                285
Ser Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys 
     290                295                300
Ala Ala Leu Arg Arg Thr Leu Asp Leu Lys Lys Ile Met Ser Ile Asn 
 305                310                315                320
Arg 
                 325



<210> 732
<211> 921
<212> DNA
<213> Homo sapiens
<308> NM_013941
<400> 732

atggtgact  agtttcttc  tctcggctt  tcccacctg  ccgacctcc  gggcttgct  60
ttctctgtc  ttctcacta  ctacctgct  accgtggca  gcaatttcc  cattgtggt  120
ctggtctcc  ctgatgctg  cctccagtc  cctatgtac  tcttcctgc  caccctctc  180
gccttggag  ttggctata  gtctgtcac  gtccccctg  tacttcacc  cctccttac  240
ggccggcgc  acatctctc  ctctggatg  gctctccag  tgttcttct  cctcttctt  300
ggcgccacg  agtgctgcc  cctggcagc  atggcctat  accgctatg  agccatctg  360
gaacccctc  gctacccac  gctgctgag  caccgggtg  gtctacagc  agctgggtc  420
gcgtgggcc  gtggggtgc  ggtggggct  ggccacacc  ctttcatct  ctctttgcc  480
ttctgcggc  ccaatacca  cccgcagtt  ttctgtgag  tccagcctg  cctgcagct  540
gtatgtgga  acacctcgc  taatgaact  cagattatc  tggcaacag  cctcctcat  600
ctctgcccc  ttggcctca  cctgggctc  tacgggcgt  tcctcgtta  catcttccg  660
atcccatct  ttgcgggcc  ccgcaaggc  ttctccacc  gctcctccc  cctgatcgt  720
gtctccctc  tctatggca  cgcactctt  atctatatt  gccctaagg  cagctacga  780
ccggccact  accctctgg  gtccctctt  tatgctgtg  tcaccccca  cctcaaccc  840
atcatctac  gcctgcgga  cacagaggt  aaagctgcc  taaagagaa  catccagaa  900
acggtgcct  tggagattt  a  921



<210> 733
<211> 306
<212> PRT
<213> Homo sapiens
<308> NP_039229
<400> 733

Met Val Thr Glu Phe Leu Leu Leu Gly Phe Ser His Leu Ala Asp Leu 
  1               5                  10                  15
Gln Gly Leu Leu Phe Ser Val Phe Leu Thr Ile Tyr Leu Leu Thr Val 
             20                  25                  30
Ala Gly Asn Phe Leu Ile Val Val Leu Val Ser Thr Asp Ala Ala Leu 
         35                  40                  45
Gln Ser Pro Met Tyr Phe Phe Leu Arg Thr Leu Ser Ala Leu Glu Ile 
     50                  55                  60
Gly Tyr Thr Ser Val Thr Val Pro Leu Leu Leu His His Leu Leu Thr 
 65                  70                  75                  80
Gly Arg Arg His Ile Ser Arg Ser Gly Cys Ala Leu Gln Met Phe Phe 
                 85                  90                  95
Phe Leu Phe Phe Gly Ala Thr Glu Cys Cys Leu Leu Ala Ala Met Ala 
             100                105                110
Tyr Asp Arg Tyr Ala Ala Ile Cys Glu Pro Leu Arg Tyr Pro Leu Leu 
         115                120                125
Leu Ser His Arg Val Cys Leu Gln Leu Ala Gly Ser Ala Trp Ala Cys 
     130                135                140
Gly Val Leu Val Gly Leu Gly His Thr Pro Phe Ile Phe Ser Leu Pro 
 145                150                155                160
Phe Cys Gly Pro Asn Thr Ile Pro Gln Phe Phe Cys Glu Ile Gln Pro 
                 165                170                175
Val Leu Gln Leu Val Cys Gly Asp Thr Ser Leu Asn Glu Leu Gln Ile 
             180                185                190
Ile Leu Ala Thr Ala Leu Leu Ile Leu Cys Pro Phe Gly Leu Ile Leu 
         195                200                205
Gly Ser Tyr Gly Arg Ile Leu Val Thr Ile Phe Arg Ile Pro Ser Val 
     210                215                220
Ala Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser His Leu Ile Val 
 225                230                235                240
Val Ser Leu Phe Tyr Gly Thr Ala Leu Phe Ile Tyr Ile Arg Pro Lys 
                 245                250                255
Ala Ser Tyr Asp Pro Ala Thr Asp Pro Leu Val Ser Leu Phe Tyr Ala 
             260                265                270
Val Val Thr Pro Ile Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Thr 
         275                280                285
Glu Val Lys Ala Ala Leu Lys Arg Thr Ile Gln Lys Thr Val Pro Met 
     290                295                300
Glu Ile 
 305



<210> 734
<211> 2890
<212> DNA
<213> Rattus norvegicus
<308> AF036255
<400> 734

cgcggcggc  gcgccggcg  ggggacaga  ggaggcgcg  gacgtgggg  ggcgccgcg  60
gcagggccg  gcggacgag  gctggcagc  ggggcagcg  tgcgggccg  tccgagtgg  120
tgcagtccg  gccttgcac  cccatcccg  tcccacgcc  tgagtgcgc  gcgcgggcc  180
caagggctg  tgttagtgg  aggaaccat  tgtggtcac  atggcaaag  gggaggaca  240
ccctggccc  gaggtgcag  caatggaca  gcagtttct  gtatgcagt  tctgcctgg  300
tcggtaccg  tgccccaaa  ttctgcctt  tctacacac  ttctgcgaa  gatgtctcc  360
gaactacat  cctcctcag  gcctgacac  ctcgtgtcc  gtatgccgg  agacatcca  420
cctcccaga  cagggtgtc  cagccctac  aaacaactt  ttcatcagc  gcctcatgg  480
ggccatgca  caggcacct  atggggccc  cgaccctga  gacccccac  ccctcagcg  540
agtggctgg  cgccctctc  cctgcccca  ccatgaagg  aagacgatg  agttttact  600
tgaggcctg  gagactgcc  tgtgtggtg  gtgccgcgc  ggggagcac  gtgaacacg  660
cacagtgct  ttgcgggac  tggtggagc  gcacaaggc  gctctacag  gccagcttg  720
agctgtgcg  ggccgattg  cacagctgt  tgcagctat  gccttggtt  ggggcatca  780
ccagcagct  caagagcgc  aggcagagg  cctggccca  ataagtgca  cctttgagg  840
cctggagca  gctctgcag  agcgcaagc  ggctctggt  agcgacttg  agagcattt  900
tggggccaa  cagaaggtg  tgcagacac  gttagacac  ctgcgccag  gtcaggaac  960
cattggcag  agctgcagc  ttgcagagc  ggcactgag  ctgggctct  cccctgagg  1020
tttgctagt  agaaagcac  tgcgagaga  gctggctgc  ctggcagct  aggccttcc  1080
agaaaggcc  catgagaat  cacagctgg  actggtcct  gaagtagat  ggttgcgga  1140
atcggtgct  aatctgggt  cactgctca  caccagtgc  gctgcacac  agacagtgg  1200
caccggcga  ggcctgcgc  aggcactgg  tggccagcc  gcctcactc  ctgtcacca  1260
caaagacaa  gatgggcgg  tggtgcgca  gggcagcgc  gagctgtgt  cagagatca  1320
tggccccga  ggcatgcgc  ttgcggtac  ggtggtgga  cacaaaaat  gcacatatg  1380
gctggtgta  acagcacgt  cagaaggcg  cctgctcct  tcagtgctg  tctatggac  1440
gccggtgcg  ggcagccct  tccgtgtgc  tgccctgag  cccggagac  tgccacctt  1500
cccagatga  gtgaagcgc  gggtcaagt  tcccggtgg  cctggcagt  atgtgcgcc  1560
gaaggcagt  cgtaggccg  gctccatgt  cagcaccgg  ggcaaacgg  aagacaatc  1620
aattgtgga  gaactcgtc  ttcgtgttg  cagtcgtgg  agggagaaa  gtgaattca  1680
caatttaca  ccgctgtcc  ctgctagca  tggccgaat  gtggtagca  acagcaaca  1740
ccaatgtat  caggttttc  ccaatgagg  ccagttcaa  ttccgattt  gagtccgtg  1800
gcgctcgcc  gggcaacta  agcgtccta  gggtgtggc  gtggacacc  atggagaca  1860
tattgtggc  gactatgac  accgttggg  cagcatctt  tctcctgag  gcaagttca  1920
gaccaaaat  ggagctggc  gcctcatgg  gcccaaggg  gtggctgtg  accggaatg  1980
gcatatcat  gtggtggat  acaagtctt  ctgtgtctt  accttccag  ccaatggca  2040
gcttgttgg  cgttttgga  gccgtgggg  cactgaccg  cacttcgca  ggccccact  2100
tgtggctgt  aacaacaag  atgagattg  agtaacgga  ttccacaac  attcagtga  2160
ggtgtacag  gctgatgga  agttcctct  caaatttgg  tcacatggc  agggcaatg  2220
acagttcaa  gcccccacg  gagtagctg  ggattccaa  ggaaacatc  tcgtggctg  2280
ctggggcaa  agtcgcata  aggtattcg  cagctctgg  tccttcctg  cctatatca  2340
cacgtctgc  gagccactg  atggcccac  gggcttggc  ttgacctcg  atggccacg  2400
agtagtggc  gatgctggc  accactgct  taaggccta  cgatacctc  agtagctgc  2460
caagggccc  gcttggctc  tggagggac  gacataggg  tgattggac  agagggtct  2520
gctaagagg  gggccagac  cggcagcac  gaatgtggg  gtgggcatg  atgtgccca  2580
tgcccttcc  ttcctcccc  accccacgg  tgcacttta  ttattcggt  cttgctttg  2640
tgactgggt  ggcctggac  ggtcccaag  atgtgtgca  agcttcacc  taactcctt  2700
acacaccct  ccttacacc  tcagtctgc  ctctgaccc  cagcctggg  cagaacagc  2760
tcttacttc  gaagtccct  tggttggct  cctaacacc  catacacac  gacagagac  2820
gcaataccc  accccatat  aaataaatg  gttcgccaa  gtgggaatt  ctggctgat  2880
cggtctcaaa  2890



<210> 735
<211> 744
<212> PRT
<213> Rattus norvegicus
<308> O70277
<400> 735

Met Ala Lys Arg Glu Asp Ser Pro Gly Pro Glu Val Gln Pro Met Asp 
  1               5                  10                  15
Lys Gln Phe Leu Val Cys Ser Ile Cys Leu Asp Arg Tyr Arg Cys Pro 
             20                  25                  30
Lys Val Leu Pro Cys Leu His Thr Phe Cys Glu Arg Cys Leu Gln Asn 
         35                  40                  45
Tyr Ile Pro Pro Gln Ser Leu Thr Leu Ser Cys Pro Val Cys Arg Gln 
     50                  55                  60
Thr Ser Ile Leu Pro Glu Gln Gly Val Ser Ala Leu Gln Asn Asn Phe 
 65                  70                  75                  80
Phe Ile Ser Ser Leu Met Glu Ala Met Gln Gln Ala Pro Asp Gly Ala 
                 85                  90                  95
His Asp Pro Glu Asp Pro His Pro Leu Ser Ala Val Ala Gly Arg Pro 
             100                105                110
Leu Ser Cys Pro Asn His Glu Gly Lys Thr Met Glu Phe Tyr Cys Glu 
         115                120                125
Ala Cys Glu Thr Ala Met Cys Gly Glu Cys Arg Ala Gly Glu His Arg 
     130                135                140
Glu His Gly Thr Val Leu Leu Arg Asp Val Val Glu Gln His Lys Ala 
 145                150                155                160
Ala Leu Gln Arg Gln Leu Glu Ala Val Arg Gly Arg Leu Pro Gln Leu 
                 165                170                175
Ser Ala Ala Ile Ala Leu Val Gly Gly Ile Ser Gln Gln Leu Gln Glu 
             180                185                190
Arg Lys Ala Glu Ala Leu Ala Gln Ile Ser Ala Ala Phe Glu Asp Leu 
         195                200                205
Glu Gln Ala Leu Gln Gln Arg Lys Gln Ala Leu Val Ser Asp Leu Glu 
     210                215                220
Ser Ile Cys Gly Ala Lys Gln Lys Val Leu Gln Thr Gln Leu Asp Thr 
 225                230                235                240
Leu Arg Gln Gly Gln Glu His Ile Gly Ser Ser Cys Ser Phe Ala Glu 
                 245                250                255
Gln Ala Leu Arg Leu Gly Ser Ala Pro Glu Val Leu Leu Val Arg Lys 
             260                265                270
His Met Arg Glu Arg Leu Ala Ala Leu Ala Ala Gln Ala Phe Pro Glu 
         275                280                285
Arg Pro His Glu Asn Ala Gln Leu Glu Leu Val Leu Glu Val Asp Gly 
     290                295                300
Leu Arg Arg Ser Val Leu Asn Leu Gly Ala Leu Leu Thr Thr Ser Ala 
 305                310                315                320
Ala Ala His Glu Thr Val Ala Thr Gly Glu Gly Leu Arg Gln Ala Leu 
                 325                330                335
Val Gly Gln Pro Ala Ser Leu Thr Val Thr Thr Lys Asp Lys Asp Gly 
             340                345                350
Arg Leu Val Arg Thr Gly Ser Ala Glu Leu Cys Ala Glu Ile Thr Gly 
         355                360                365
Pro Asp Gly Met Arg Leu Ala Val Pro Val Val Asp His Lys Asn Gly 
     370                375                380
Thr Tyr Glu Leu Val Tyr Thr Ala Arg Thr Glu Gly Asp Leu Leu Leu 
 385                390                395                400
Ser Val Leu Leu Tyr Gly Gln Pro Val Arg Gly Ser Pro Phe Arg Val 
                 405                410                415
Arg Ala Leu Arg Pro Gly Asp Leu Pro Pro Ser Pro Asp Asp Val Lys 
             420                425                430
Arg Arg Val Lys Ser Pro Gly Gly Pro Gly Ser His Val Arg Gln Lys 
         435                440                445
Ala Val Arg Arg Pro Ser Ser Met Tyr Ser Thr Gly Gly Lys Arg Lys 
     450                455                460
Asp Asn Pro Ile Val Asp Glu Leu Val Phe Arg Val Gly Ser Arg Gly 
 465                470                475                480
Arg Glu Lys Gly Glu Phe Thr Asn Leu His Pro Leu Ser Ala Ala Ser 
                 485                490                495
Ser Gly Arg Ile Val Val Ala Asp Ser Asn Asn Gln Cys Ile Gln Val 
             500                505                510
Phe Ser Asn Glu Gly Gln Phe Lys Phe Arg Phe Gly Val Arg Gly Arg 
         515                520                525
Ser Pro Gly Gln Leu Gln Arg Pro Thr Gly Val Ala Val Asp Thr Asn 
     530                535                540
Gly Asp Ile Ile Val Ala Asp Tyr Asp Asn Arg Trp Val Ser Ile Phe 
 545                550                555                560
Ser Pro Glu Gly Lys Phe Lys Thr Lys Ile Gly Ala Gly Arg Leu Met 
                 565                570                575
Gly Pro Lys Gly Val Ala Val Asp Arg Asn Gly His Ile Ile Val Val 
             580                585                590
Asp Asn Lys Ser Cys Cys Val Phe Thr Phe Gln Pro Asn Gly Lys Leu 
         595                600                605
Val Gly Arg Phe Gly Gly Arg Gly Ala Thr Asp Arg His Phe Ala Gly 
     610                615                620
Pro His Phe Val Ala Val Asn Asn Lys Asn Glu Ile Val Val Thr Asp 
 625                630                635                640
Phe His Asn His Ser Val Lys Val Tyr Ser Ala Asp Gly Glu Phe Leu 
                 645                650                655
Phe Lys Phe Gly Ser His Gly Glu Gly Asn Gly Gln Phe Asn Ala Pro 
             660                665                670
Thr Gly Val Ala Val Asp Ser Asn Gly Asn Ile Ile Val Ala Asp Trp 
         675                680                685
Gly Asn Ser Arg Ile Gln Val Phe Asp Ser Ser Gly Ser Phe Leu Ser 
     690                695                700
Tyr Ile Asn Thr Ser Ala Glu Pro Leu Tyr Gly Pro Gln Gly Leu Ala 
 705                710                715                720
Leu Thr Ser Asp Gly His Val Val Val Ala Asp Ala Gly Asn His Cys 
                 725                730                735
Phe Lys Ala Tyr Arg Tyr Leu Gln 
             740



<210> 736
<211> 2227
<212> DNA
<213> Homo sapiens
<308> AF220021
<400> 736

atggcaaag  gggaggaca  ccctggccc  gaggtccag  caatggaca  gcagttctt  60
gtatgcagc  tctgcctgg  tcggtacca  tgccccaag  ttcttcctt  cctgcacac  120
ttctgtgag  gatgtctcc  aaactatat  cctgcccag  gcctgacgc  atcctgtcc  180
gtatgccgg  agacgtcca  cctcccaga  cagggcgtc  cggcactgc  gaacaactt  240
ttcatcagc  gcctcatgg  ggcaatgca  caggcacct  atggggccc  cgacccgga  300
gacccccac  ccctcagtg  agtggctgg  cgccctttc  cctgcccca  ccatgaagg  360
aagacgatg  agttttact  tgaggcctg  gagacggcc  tgtgtggtg  gtgccgcgc  420
ggggagcat  gtgagcagc  caaggcggc  ctgcagcgc  agctcgagg  tgtgcgtgg  480
cgattgcca  agctgtccg  agcaattgc  ttagtcggg  gcatcagcc  gcagctgca  540
gagcgcaag  cagaggccc  ggcccagat  agtgcagcg  tcgaggacc  ggagcaagc  600
ctgcagcag  gcaagcagg  tctggtcag  gacctggag  ccatttgtg  ggccaaaca  660
aaggtgttg  aaacccagc  ggacacact  cgccagggt  aggaacaca  cggcagtag  720
tgcagcttt  cagagcagg  actgcgcct  ggctcggcc  cggaggtgt  gctggtgcg  780
aagcacatg  gagagcggc  ggctgcatt  gcggcacag  ccttcccgg  gcggccaca  840
gagaatgca  agctggaac  ggtccttga  gtggacggt  tgcggcgat  ggtgctcaa  900
ctgggtgca  tgctcacca  gagcgccac  gcacacgaa  cggtggcca  gggagaggg  960
ctgcgccag  cgctagtgg  ccagcctgc  tcgctcact  tcactgcca  agacaagga  1020
gggcggttg  tgcgcacag  cagcgctga  ctgcgtgca  agatcaccg  cccggacgg  1080
acgcgcctt  cggtgccag  ggtggacca  aagaatggc  catatgagc  agtgtacac  1140
gcgcgcacg  aaggcgagc  gctcctctc  gtgctgctc  acggacagc  agtgcgcgg  1200
agccccttc  gcgtgcgtg  cctgcgtcc  ggggacctg  caccttccc  ggacgatgt  1260
aagcgccgt  tcaagtccc  tggcggccc  ggcagccat  tgcgccaga  ggcagtgcg  1320
aggcccagc  ccatgtaca  cacaggcgg  aaacgaaag  acaacccaa  tgaggatga  1380
ctcgtcttc  gtgttggca  tcgtggaag  gagaaaggt  aattcacca  tttacaagg  1440
gtgtccgca  ccagcagcg  ccgcatcgt  gtagcagac  gcaacaacc  gtgtattca  1500
gttttctcc  atgagggcc  gttcaagtt  cgttttggg  tccgaggac  ctcacctgg  1560
cagctgcag  gccccacag  tgtggcagt  gacaccaat  gagacataa  tgtggcaga  1620
tatgacaac  gttgggtca  catcttctc  cctgagggc  agttcaaga  caagattgg  1680
gctggccgc  tcatgggcc  caagggagt  gccgtagac  ggaatggac  tatcattgt  1740
gtcgacaac  agtcttgct  cgtctttac  ttccagccc  atggcaaac  ggttggccg  1800
tttgggggc  gtggggcca  tgaccgcca  tttgcaggg  cccattttg  ggctgtaag  1860
aacaagaat  aagttgtag  aacggactt  cataaccat  cagagaagg  gtacagtgc  1920
gatggagag  tcctcttca  gtttggctc  catggcgag  gcaatgggc  gttcaatgc  1980
cccacagga  tagctgtgg  ctccaatgg  aacatcatt  tggctgact  gggcaacag  2040
cgcatccag  tattcgaca  ctctggctc  ttcctgtcc  atatcaaca  atctgcaga  2100
ccactgtat  gtccacagg  cctggcact  acctcggat  gccatgtgg  ggtggctga  2160
gctggcaac  actgcttta  agcctatcg  tacctccag  agctgtaca  aggccctgc  2220
tggcttg  2227



<210> 737
<211> 744
<212> PRT
<213> Homo sapiens
<308> O75382
<400> 737

Met Ala Lys Arg Glu Asp Ser Pro Gly Pro Glu Val Gln Pro Met Asp 
  1               5                  10                  15
Lys Gln Phe Leu Val Cys Ser Ile Cys Leu Asp Arg Tyr Gln Cys Pro 
             20                  25                  30
Lys Val Leu Pro Cys Leu His Thr Phe Cys Glu Arg Cys Leu Gln Asn 
         35                  40                  45
Tyr Ile Pro Ala Gln Ser Leu Thr Leu Ser Cys Pro Val Cys Arg Gln 
     50                  55                  60
Thr Ser Ile Leu Pro Glu Gln Gly Val Ser Ala Leu Gln Asn Asn Phe 
 65                  70                  75                  80
Phe Ile Ser Ser Leu Met Glu Ala Met Gln Gln Ala Pro Asp Gly Ala 
                 85                  90                  95
His Asp Pro Glu Asp Pro His Pro Leu Ser Val Val Ala Gly Arg Pro 
             100                105                110
Phe Ser Cys Pro Asn His Glu Gly Lys Thr Met Glu Phe Tyr Cys Glu 
         115                120                125
Ala Cys Glu Thr Ala Met Cys Gly Glu Cys Arg Ala Gly Glu His Arg 
     130                135                140
Glu His Gly Thr Val Leu Leu Arg Asp Val Val Glu Gln His Lys Ala 
 145                150                155                160
Ala Leu Gln Arg Gln Leu Glu Ala Val Arg Gly Arg Leu Pro Gln Leu 
                 165                170                175
Ser Ala Ala Ile Ala Leu Val Gly Gly Ile Ser Gln Gln Leu Gln Glu 
             180                185                190
Arg Lys Ala Glu Ala Leu Ala Gln Ile Ser Ala Ala Phe Glu Asp Leu 
         195                200                205
Glu Gln Ala Leu Gln Gln Arg Lys Gln Ala Leu Val Ser Asp Leu Glu 
     210                215                220
Thr Ile Cys Gly Ala Lys Gln Lys Val Leu Gln Thr Gln Leu Asp Thr 
 225                230                235                240
Leu Arg Gln Gly Gln Glu His Ile Gly Ser Ser Cys Ser Phe Ala Glu 
                 245                250                255
Gln Ala Leu Arg Leu Gly Ser Ala Pro Glu Val Leu Leu Val Arg Lys 
             260                265                270
His Met Arg Glu Arg Leu Ala Ala Leu Ala Ala Gln Ala Phe Pro Glu 
         275                280                285
Arg Pro His Glu Asn Ala Gln Leu Glu Leu Val Leu Glu Val Asp Gly 
     290                295                300
Leu Arg Arg Ser Val Leu Asn Leu Gly Ala Leu Leu Thr Thr Ser Ala 
 305                310                315                320
Thr Ala His Glu Thr Val Ala Thr Gly Glu Gly Leu Arg Gln Ala Leu 
                 325                330                335
Val Gly Gln Pro Ala Ser Leu Thr Val Thr Ala Lys Asp Lys Asp Gly 
             340                345                350
Arg Leu Val Arg Thr Gly Ser Ala Glu Leu Arg Ala Glu Ile Thr Gly 
         355                360                365
Pro Asp Gly Thr Arg Leu Pro Val Pro Val Val Asp His Lys Asn Gly 
     370                375                380
Thr Tyr Glu Leu Val Tyr Thr Ala Arg Thr Glu Gly Glu Leu Leu Leu 
 385                390                395                400
Ser Val Leu Leu Tyr Gly Gln Pro Val Arg Gly Ser Pro Phe Arg Val 
                 405                410                415
Arg Ala Leu Arg Pro Gly Asp Leu Pro Pro Ser Pro Asp Asp Val Lys 
             420                425                430
Arg Arg Val Lys Ser Pro Gly Gly Pro Gly Ser His Val Arg Gln Lys 
         435                440                445
Ala Val Arg Arg Pro Ser Ser Met Tyr Ser Thr Gly Gly Lys Arg Lys 
     450                455                460
Asp Asn Pro Ile Glu Asp Glu Leu Val Phe Arg Val Gly Ser Arg Gly 
 465                470                475                480
Arg Glu Lys Gly Glu Phe Thr Asn Leu Gln Gly Val Ser Ala Ala Ser 
                 485                490                495
Ser Gly Arg Ile Val Val Ala Asp Ser Asn Asn Gln Cys Ile Gln Val 
             500                505                510
Phe Ser Asn Glu Gly Gln Phe Lys Phe Arg Phe Gly Val Arg Gly Arg 
         515                520                525
Ser Pro Gly Gln Leu Gln Arg Pro Thr Gly Val Ala Val Asp Thr Asn 
     530                535                540
Gly Asp Ile Ile Val Ala Asp Tyr Asp Asn Arg Trp Val Ser Ile Phe 
 545                550                555                560
Ser Pro Glu Gly Lys Phe Lys Thr Lys Ile Gly Ala Gly Arg Leu Met 
                 565                570                575
Gly Pro Lys Gly Val Ala Val Asp Arg Asn Gly His Ile Ile Val Val 
             580                585                590
Asp Asn Lys Ser Cys Cys Val Phe Thr Phe Gln Pro Asn Gly Lys Leu 
         595                600                605
Val Gly Arg Phe Gly Gly Arg Gly Ala Thr Asp Arg His Phe Ala Gly 
     610                615                620
Pro His Phe Val Ala Val Ser Asn Lys Asn Glu Val Val Val Thr Asp 
 625                630                635                640
Phe His Asn His Ser Glu Lys Val Tyr Ser Ala Asp Gly Glu Phe Leu 
                 645                650                655
Phe Lys Phe Gly Ser His Gly Glu Gly Asn Gly Gln Phe Asn Ala Pro 
             660                665                670
Thr Gly Val Ala Val Asp Ser Asn Gly Asn Ile Ile Val Ala Asp Trp 
         675                680                685
Gly Asn Ser Arg Ile Gln Val Phe Asp Ser Ser Gly Ser Phe Leu Ser 
     690                695                700
Tyr Ile Asn Thr Ser Ala Glu Pro Leu Tyr Gly Pro Gln Gly Leu Ala 
 705                710                715                720
Leu Thr Ser Asp Gly His Val Val Val Ala Asp Ala Gly Asn His Cys 
                 725                730                735
Phe Lys Ala Tyr Arg Tyr Leu Gln 
             740



<210> 738
<211> 1039
<212> DNA
<213> Rattus norvegicus
<308> AF036335
<400> 738

gaaacgcct  ctcgttttg  tcagcatgg  acatttgag  atgaatatt  tcaacgatg  60
aagtctttg  atgaaatgg  aaaacagca  agggaacaa  ttgaaaaaa  catgaagga  120
gcaaaagac  agttggaaa  tgaaatgga  gatgcctac  atgaacacc  agcaaatct  180
ttgcgccaa  atctgatga  acgccagga  gaattaagg  gcatggagg  acttcacag  240
caagaaatg  agaaacgta  agaaatgca  ttgaggcaa  aggaggaac  gcgtacaag  300
gaggaagag  tgatgattc  ccaacgtga  atggaagaa  aaatgagac  ccaacgaga  360
gaaagctac  gcaggatgg  ctacatgga  cccaagaga  agagacatg  gaatgggtg  420
tggtggaac  atgaacatg  gagatccct  tggttcagg  ggccagaaa  ttccaccgc  480
aggtggtgg  ggtggcata  gttatgaag  taatcctgg  gttccacca  caaccatga  540
tggttccat  atgggaagc  acatgcgta  tgagcgctt  gggcaggga  gtgcgggtc  600
tgtgggtgg  cagggtcct  gaggaatgg  gcctggaac  ccagcagga  atggtagag  660
gagagaaga  tatgaaggg  caaataaaa  accccgatt  tagatactt  ggctttcat  720
ccagtttgg  tttgtcttc  tgtttagat  ccacttaaa  tcttggcat  ttagtaaga  780
agctacctt  ttatggatg  tagcagttt  ttgacctga  atttgtaaa  ggcctgttt  840
ggcaggtaa  attatgtaa  gcagtgttc  aaacaggag  aaaattttt  catttactt  900
ttttttaac  gtataatgt  tctcaagtt  atggcagtg  accttgtgc  actgaattt  960
caaagtgta  cattttttt  ttactgtgc  tcaaataaa  agaaaaaaa  agttatgaa  1020
aaaaaaaaa  aaaaaaaaa  1039



<210> 739
<211> 168
<212> PRT
<213> Rattus norvegicus
<308> AAD05362
<400> 739

Glu Thr Pro Pro Arg Phe Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr 
  1               5                  10                  15
Ser Gln Arg Trp Lys Ser Leu Asp Glu Met Glu Lys Gln Gln Arg Glu 
             20                  25                  30
Gln Val Glu Lys Asn Met Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu 
         35                  40                  45
Met Glu Asp Ala Tyr His Glu His Gln Ala Asn Leu Leu Arg Gln Asp 
     50                  55                  60
Leu Met Arg Arg Gln Glu Glu Leu Arg Arg Met Glu Glu Leu His Ser 
 65                  70                  75                  80
Gln Glu Met Gln Lys Arg Lys Glu Met Gln Leu Arg Gln Glu Glu Glu 
                 85                  90                  95
Arg Arg Thr Arg Glu Glu Glu Met Met Ile Arg Gln Arg Glu Met Glu 
             100                105                110
Glu Gln Met Arg Arg Gln Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr 
         115                120                125
Met Asp Pro Lys Arg Lys Arg His Glu Asn Gly Trp Trp Trp Asn Asn 
     130                135                140
Glu His Gly Arg Ser Leu Trp Phe Arg Arg Pro Glu Ile Ser Thr Ala 
 145                150                155                160
Arg Trp Trp Trp Trp His Arg Leu 
                 165



<210> 740
<211> 707
<212> PRT
<213> Homo sapiens
<308> P23246
<400> 740

Met Ser Arg Asp Arg Phe Arg Ser Arg Gly Gly Gly Gly Gly Gly Phe 
  1               5                  10                  15
His Arg Arg Gly Gly Gly Gly Gly Arg Gly Gly Leu His Asp Phe Arg 
             20                  25                  30
Ser Pro Pro Pro Gly Met Gly Leu Asn Gln Asn Arg Gly Pro Met Gly 
         35                  40                  45
Pro Gly Pro Gly Gln Ser Gly Pro Lys Pro Pro Ile Pro Pro Pro Pro 
     50                  55                  60
Pro His Gln Gln Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Gln 
 65                  70                  75                  80
Gln Pro Pro Pro His Gln Pro Pro Pro His Pro Gln Pro His Gln Gln 
                 85                  90                  95
Gln Gln Pro Pro Pro Pro Pro Gln Asp Ser Ser Lys Pro Val Val Ala 
             100                105                110
Gln Gly Pro Gly Pro Ala Pro Gly Val Gly Ser Ala Pro Pro Ala Ser 
         115                120                125
Ser Ser Ala Pro Pro Ala Thr Pro Pro Thr Ser Gly Ala Pro Pro Gly 
     130                135                140
Ser Gly Pro Gly Pro Thr Pro Thr Pro Pro Pro Ala Val Thr Ser Ala 
 145                150                155                160
Pro Pro Gly Ala Pro Pro Pro Thr Pro Pro Ser Ser Gly Val Pro Thr 
                 165                170                175
Thr Pro Pro Gln Ala Gly Gly Pro Pro Pro Pro Pro Ala Ala Val Pro 
             180                185                190
Gly Pro Gly Pro Gly Pro Lys Gln Gly Pro Gly Pro Gly Gly Pro Lys 
         195                200                205
Gly Gly Lys Met Pro Gly Gly Pro Lys Pro Gly Gly Gly Pro Gly Leu 
     210                215                220
Ser Thr Pro Gly Gly His Pro Lys Pro Pro His Arg Gly Gly Gly Glu 
 225                230                235                240
Pro Arg Gly Gly Arg Gln His His Pro Pro Tyr His Gln Gln His His 
                 245                250                255
Gln Gly Pro Pro Pro Gly Gly Pro Gly Gly Arg Ser Glu Glu Lys Ile 
             260                265                270
Ser Asp Ser Glu Gly Phe Lys Ala Asn Leu Ser Leu Leu Arg Arg Pro 
         275                280                285
Gly Glu Lys Thr Tyr Thr Gln Arg Cys Arg Leu Phe Val Gly Asn Leu 
     290                295                300
Pro Ala Asp Ile Thr Glu Asp Glu Phe Lys Arg Leu Phe Ala Lys Tyr 
 305                310                315                320
Gly Glu Pro Gly Glu Val Phe Ile Asn Lys Gly Lys Gly Phe Gly Phe 
                 325                330                335
Ile Lys Leu Glu Ser Arg Ala Leu Ala Glu Ile Ala Lys Ala Glu Leu 
             340                345                350
Asp Asp Thr Pro Met Arg Gly Arg Gln Leu Arg Val Arg Phe Ala Thr 
         355                360                365
His Ala Ala Ala Leu Ser Val Arg Asn Leu Ser Pro Tyr Val Ser Asn 
     370                375                380
Glu Leu Leu Glu Glu Ala Phe Ser Gln Phe Gly Pro Ile Glu Arg Ala 
 385                390                395                400
Val Val Ile Val Asp Asp Arg Gly Arg Ser Thr Gly Lys Gly Ile Val 
                 405                410                415
Glu Phe Ala Ser Lys Pro Ala Ala Arg Lys Ala Phe Glu Arg Cys Ser 
             420                425                430
Glu Gly Val Phe Leu Leu Thr Thr Thr Pro Arg Pro Val Ile Val Glu 
         435                440                445
Pro Leu Glu Gln Leu Asp Asp Glu Asp Gly Leu Pro Glu Lys Leu Ala 
     450                455                460
Gln Lys Asn Pro Met Tyr Gln Lys Glu Arg Glu Thr Pro Pro Arg Phe 
 465                470                475                480
Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr Ser Gln Arg Trp Lys Ser 
                 485                490                495
Leu Asp Glu Met Glu Lys Gln Gln Arg Glu Gln Val Glu Lys Asn Met 
             500                505                510
Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu Met Glu Asp Ala Tyr His 
         515                520                525
Glu His Gln Ala Asn Leu Leu Arg Gln Asp Leu Met Arg Arg Gln Glu 
     530                535                540
Glu Leu Arg Arg Met Glu Glu Leu His Asn Gln Glu Met Gln Lys Arg 
 545                550                555                560
Lys Glu Met Gln Leu Arg Gln Glu Glu Glu Arg Arg Arg Arg Glu Glu 
                 565                570                575
Glu Met Met Ile Arg Gln Arg Glu Met Glu Glu Gln Met Arg Arg Gln 
             580                585                590
Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr Met Asp Pro Arg Glu Arg 
         595                600                605
Asp Met Arg Met Gly Gly Gly Gly Ala Met Asn Met Gly Asp Pro Tyr 
     610                615                620
Gly Ser Gly Gly Gln Lys Phe Pro Pro Leu Gly Gly Gly Gly Gly Ile 
 625                630                635                640
Gly Tyr Glu Ala Asn Pro Gly Val Pro Pro Ala Thr Met Ser Gly Ser 
                 645                650                655
Met Met Gly Ser Asp Met Arg Thr Glu Arg Phe Gly Gln Gly Gly Ala 
             660                665                670
Gly Pro Val Gly Gly Gln Gly Pro Arg Gly Met Gly Pro Gly Thr Pro 
         675                680                685
Ala Gly Tyr Gly Arg Gly Arg Glu Glu Tyr Glu Gly Pro Asn Lys Lys 
     690                695                700
Pro Arg Phe 
 705



<210> 741
<211> 1039
<212> DNA
<213> Rattus norvegicus
<308> AF036335
<400> 741

gaaacgcct  ctcgttttg  tcagcatgg  acatttgag  atgaatatt  tcaacgatg  60
aagtctttg  atgaaatgg  aaaacagca  agggaacaa  ttgaaaaaa  catgaagga  120
gcaaaagac  agttggaaa  tgaaatgga  gatgcctac  atgaacacc  agcaaatct  180
ttgcgccaa  atctgatga  acgccagga  gaattaagg  gcatggagg  acttcacag  240
caagaaatg  agaaacgta  agaaatgca  ttgaggcaa  aggaggaac  gcgtacaag  300
gaggaagag  tgatgattc  ccaacgtga  atggaagaa  aaatgagac  ccaacgaga  360
gaaagctac  gcaggatgg  ctacatgga  cccaagaga  agagacatg  gaatgggtg  420
tggtggaac  atgaacatg  gagatccct  tggttcagg  ggccagaaa  ttccaccgc  480
aggtggtgg  ggtggcata  gttatgaag  taatcctgg  gttccacca  caaccatga  540
tggttccat  atgggaagc  acatgcgta  tgagcgctt  gggcaggga  gtgcgggtc  600
tgtgggtgg  cagggtcct  gaggaatgg  gcctggaac  ccagcagga  atggtagag  660
gagagaaga  tatgaaggg  caaataaaa  accccgatt  tagatactt  ggctttcat  720
ccagtttgg  tttgtcttc  tgtttagat  ccacttaaa  tcttggcat  ttagtaaga  780
agctacctt  ttatggatg  tagcagttt  ttgacctga  atttgtaaa  ggcctgttt  840
ggcaggtaa  attatgtaa  gcagtgttc  aaacaggag  aaaattttt  catttactt  900
ttttttaac  gtataatgt  tctcaagtt  atggcagtg  accttgtgc  actgaattt  960
caaagtgta  cattttttt  ttactgtgc  tcaaataaa  agaaaaaaa  agttatgaa  1020
aaaaaaaaa  aaaaaaaaa  1039



<210> 742
<211> 168
<212> PRT
<213> Rattus norvegicus
<308> AAD05362
<400> 742

Glu Thr Pro Pro Arg Phe Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr 
  1               5                  10                  15
Ser Gln Arg Trp Lys Ser Leu Asp Glu Met Glu Lys Gln Gln Arg Glu 
             20                  25                  30
Gln Val Glu Lys Asn Met Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu 
         35                  40                  45
Met Glu Asp Ala Tyr His Glu His Gln Ala Asn Leu Leu Arg Gln Asp 
     50                  55                  60
Leu Met Arg Arg Gln Glu Glu Leu Arg Arg Met Glu Glu Leu His Ser 
 65                  70                  75                  80
Gln Glu Met Gln Lys Arg Lys Glu Met Gln Leu Arg Gln Glu Glu Glu 
                 85                  90                  95
Arg Arg Thr Arg Glu Glu Glu Met Met Ile Arg Gln Arg Glu Met Glu 
             100                105                110
Glu Gln Met Arg Arg Gln Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr 
         115                120                125
Met Asp Pro Lys Arg Lys Arg His Glu Asn Gly Trp Trp Trp Asn Asn 
     130                135                140
Glu His Gly Arg Ser Leu Trp Phe Arg Arg Pro Glu Ile Ser Thr Ala 
 145                150                155                160
Arg Trp Trp Trp Trp His Arg Leu 
                 165



<210> 743
<211> 707
<212> PRT
<213> Homo sapiens
<308> P23246
<400> 743

Met Ser Arg Asp Arg Phe Arg Ser Arg Gly Gly Gly Gly Gly Gly Phe 
  1               5                  10                  15
His Arg Arg Gly Gly Gly Gly Gly Arg Gly Gly Leu His Asp Phe Arg 
             20                  25                  30
Ser Pro Pro Pro Gly Met Gly Leu Asn Gln Asn Arg Gly Pro Met Gly 
         35                  40                  45
Pro Gly Pro Gly Gln Ser Gly Pro Lys Pro Pro Ile Pro Pro Pro Pro 
     50                  55                  60
Pro His Gln Gln Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Gln 
 65                  70                  75                  80
Gln Pro Pro Pro His Gln Pro Pro Pro His Pro Gln Pro His Gln Gln 
                 85                  90                  95
Gln Gln Pro Pro Pro Pro Pro Gln Asp Ser Ser Lys Pro Val Val Ala 
             100                105                110
Gln Gly Pro Gly Pro Ala Pro Gly Val Gly Ser Ala Pro Pro Ala Ser 
         115                120                125
Ser Ser Ala Pro Pro Ala Thr Pro Pro Thr Ser Gly Ala Pro Pro Gly 
     130                135                140
Ser Gly Pro Gly Pro Thr Pro Thr Pro Pro Pro Ala Val Thr Ser Ala 
 145                150                155                160
Pro Pro Gly Ala Pro Pro Pro Thr Pro Pro Ser Ser Gly Val Pro Thr 
                 165                170                175
Thr Pro Pro Gln Ala Gly Gly Pro Pro Pro Pro Pro Ala Ala Val Pro 
             180                185                190
Gly Pro Gly Pro Gly Pro Lys Gln Gly Pro Gly Pro Gly Gly Pro Lys 
         195                200                205
Gly Gly Lys Met Pro Gly Gly Pro Lys Pro Gly Gly Gly Pro Gly Leu 
     210                215                220
Ser Thr Pro Gly Gly His Pro Lys Pro Pro His Arg Gly Gly Gly Glu 
 225                230                235                240
Pro Arg Gly Gly Arg Gln His His Pro Pro Tyr His Gln Gln His His 
                 245                250                255
Gln Gly Pro Pro Pro Gly Gly Pro Gly Gly Arg Ser Glu Glu Lys Ile 
             260                265                270
Ser Asp Ser Glu Gly Phe Lys Ala Asn Leu Ser Leu Leu Arg Arg Pro 
         275                280                285
Gly Glu Lys Thr Tyr Thr Gln Arg Cys Arg Leu Phe Val Gly Asn Leu 
     290                295                300
Pro Ala Asp Ile Thr Glu Asp Glu Phe Lys Arg Leu Phe Ala Lys Tyr 
 305                310                315                320
Gly Glu Pro Gly Glu Val Phe Ile Asn Lys Gly Lys Gly Phe Gly Phe 
                 325                330                335
Ile Lys Leu Glu Ser Arg Ala Leu Ala Glu Ile Ala Lys Ala Glu Leu 
             340                345                350
Asp Asp Thr Pro Met Arg Gly Arg Gln Leu Arg Val Arg Phe Ala Thr 
         355                360                365
His Ala Ala Ala Leu Ser Val Arg Asn Leu Ser Pro Tyr Val Ser Asn 
     370                375                380
Glu Leu Leu Glu Glu Ala Phe Ser Gln Phe Gly Pro Ile Glu Arg Ala 
 385                390                395                400
Val Val Ile Val Asp Asp Arg Gly Arg Ser Thr Gly Lys Gly Ile Val 
                 405                410                415
Glu Phe Ala Ser Lys Pro Ala Ala Arg Lys Ala Phe Glu Arg Cys Ser 
             420                425                430
Glu Gly Val Phe Leu Leu Thr Thr Thr Pro Arg Pro Val Ile Val Glu 
         435                440                445
Pro Leu Glu Gln Leu Asp Asp Glu Asp Gly Leu Pro Glu Lys Leu Ala 
     450                455                460
Gln Lys Asn Pro Met Tyr Gln Lys Glu Arg Glu Thr Pro Pro Arg Phe 
 465                470                475                480
Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr Ser Gln Arg Trp Lys Ser 
                 485                490                495
Leu Asp Glu Met Glu Lys Gln Gln Arg Glu Gln Val Glu Lys Asn Met 
             500                505                510
Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu Met Glu Asp Ala Tyr His 
         515                520                525
Glu His Gln Ala Asn Leu Leu Arg Gln Asp Leu Met Arg Arg Gln Glu 
     530                535                540
Glu Leu Arg Arg Met Glu Glu Leu His Asn Gln Glu Met Gln Lys Arg 
 545                550                555                560
Lys Glu Met Gln Leu Arg Gln Glu Glu Glu Arg Arg Arg Arg Glu Glu 
                 565                570                575
Glu Met Met Ile Arg Gln Arg Glu Met Glu Glu Gln Met Arg Arg Gln 
             580                585                590
Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr Met Asp Pro Arg Glu Arg 
         595                600                605
Asp Met Arg Met Gly Gly Gly Gly Ala Met Asn Met Gly Asp Pro Tyr 
     610                615                620
Gly Ser Gly Gly Gln Lys Phe Pro Pro Leu Gly Gly Gly Gly Gly Ile 
 625                630                635                640
Gly Tyr Glu Ala Asn Pro Gly Val Pro Pro Ala Thr Met Ser Gly Ser 
                 645                650                655
Met Met Gly Ser Asp Met Arg Thr Glu Arg Phe Gly Gln Gly Gly Ala 
             660                665                670
Gly Pro Val Gly Gly Gln Gly Pro Arg Gly Met Gly Pro Gly Thr Pro 
         675                680                685
Ala Gly Tyr Gly Arg Gly Arg Glu Glu Tyr Glu Gly Pro Asn Lys Lys 
     690                695                700
Pro Arg Phe 
 705



<210> 744
<211> 1039
<212> DNA
<213> Rattus norvegicus
<308> AF036335
<400> 744

gaaacgcct  ctcgttttg  tcagcatgg  acatttgag  atgaatatt  tcaacgatg  60
aagtctttg  atgaaatgg  aaaacagca  agggaacaa  ttgaaaaaa  catgaagga  120
gcaaaagac  agttggaaa  tgaaatgga  gatgcctac  atgaacacc  agcaaatct  180
ttgcgccaa  atctgatga  acgccagga  gaattaagg  gcatggagg  acttcacag  240
caagaaatg  agaaacgta  agaaatgca  ttgaggcaa  aggaggaac  gcgtacaag  300
gaggaagag  tgatgattc  ccaacgtga  atggaagaa  aaatgagac  ccaacgaga  360
gaaagctac  gcaggatgg  ctacatgga  cccaagaga  agagacatg  gaatgggtg  420
tggtggaac  atgaacatg  gagatccct  tggttcagg  ggccagaaa  ttccaccgc  480
aggtggtgg  ggtggcata  gttatgaag  taatcctgg  gttccacca  caaccatga  540
tggttccat  atgggaagc  acatgcgta  tgagcgctt  gggcaggga  gtgcgggtc  600
tgtgggtgg  cagggtcct  gaggaatgg  gcctggaac  ccagcagga  atggtagag  660
gagagaaga  tatgaaggg  caaataaaa  accccgatt  tagatactt  ggctttcat  720
ccagtttgg  tttgtcttc  tgtttagat  ccacttaaa  tcttggcat  ttagtaaga  780
agctacctt  ttatggatg  tagcagttt  ttgacctga  atttgtaaa  ggcctgttt  840
ggcaggtaa  attatgtaa  gcagtgttc  aaacaggag  aaaattttt  catttactt  900
ttttttaac  gtataatgt  tctcaagtt  atggcagtg  accttgtgc  actgaattt  960
caaagtgta  cattttttt  ttactgtgc  tcaaataaa  agaaaaaaa  agttatgaa  1020
aaaaaaaaa  aaaaaaaaa  1039



<210> 745
<211> 168
<212> PRT
<213> Rattus norvegicus
<308> AAD05362
<400> 745

Glu Thr Pro Pro Arg Phe Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr 
  1               5                  10                  15
Ser Gln Arg Trp Lys Ser Leu Asp Glu Met Glu Lys Gln Gln Arg Glu 
             20                  25                  30
Gln Val Glu Lys Asn Met Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu 
         35                  40                  45
Met Glu Asp Ala Tyr His Glu His Gln Ala Asn Leu Leu Arg Gln Asp 
     50                  55                  60
Leu Met Arg Arg Gln Glu Glu Leu Arg Arg Met Glu Glu Leu His Ser 
 65                  70                  75                  80
Gln Glu Met Gln Lys Arg Lys Glu Met Gln Leu Arg Gln Glu Glu Glu 
                 85                  90                  95
Arg Arg Thr Arg Glu Glu Glu Met Met Ile Arg Gln Arg Glu Met Glu 
             100                105                110
Glu Gln Met Arg Arg Gln Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr 
         115                120                125
Met Asp Pro Lys Arg Lys Arg His Glu Asn Gly Trp Trp Trp Asn Asn 
     130                135                140
Glu His Gly Arg Ser Leu Trp Phe Arg Arg Pro Glu Ile Ser Thr Ala 
 145                150                155                160
Arg Trp Trp Trp Trp His Arg Leu 
                 165



<210> 746
<211> 707
<212> PRT
<213> Homo sapiens
<308> P23246
<400> 746

Met Ser Arg Asp Arg Phe Arg Ser Arg Gly Gly Gly Gly Gly Gly Phe 
  1               5                  10                  15
His Arg Arg Gly Gly Gly Gly Gly Arg Gly Gly Leu His Asp Phe Arg 
             20                  25                  30
Ser Pro Pro Pro Gly Met Gly Leu Asn Gln Asn Arg Gly Pro Met Gly 
         35                  40                  45
Pro Gly Pro Gly Gln Ser Gly Pro Lys Pro Pro Ile Pro Pro Pro Pro 
     50                  55                  60
Pro His Gln Gln Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Gln 
 65                  70                  75                  80
Gln Pro Pro Pro His Gln Pro Pro Pro His Pro Gln Pro His Gln Gln 
                 85                  90                  95
Gln Gln Pro Pro Pro Pro Pro Gln Asp Ser Ser Lys Pro Val Val Ala 
             100                105                110
Gln Gly Pro Gly Pro Ala Pro Gly Val Gly Ser Ala Pro Pro Ala Ser 
         115                120                125
Ser Ser Ala Pro Pro Ala Thr Pro Pro Thr Ser Gly Ala Pro Pro Gly 
     130                135                140
Ser Gly Pro Gly Pro Thr Pro Thr Pro Pro Pro Ala Val Thr Ser Ala 
 145                150                155                160
Pro Pro Gly Ala Pro Pro Pro Thr Pro Pro Ser Ser Gly Val Pro Thr 
                 165                170                175
Thr Pro Pro Gln Ala Gly Gly Pro Pro Pro Pro Pro Ala Ala Val Pro 
             180                185                190
Gly Pro Gly Pro Gly Pro Lys Gln Gly Pro Gly Pro Gly Gly Pro Lys 
         195                200                205
Gly Gly Lys Met Pro Gly Gly Pro Lys Pro Gly Gly Gly Pro Gly Leu 
     210                215                220
Ser Thr Pro Gly Gly His Pro Lys Pro Pro His Arg Gly Gly Gly Glu 
 225                230                235                240
Pro Arg Gly Gly Arg Gln His His Pro Pro Tyr His Gln Gln His His 
                 245                250                255
Gln Gly Pro Pro Pro Gly Gly Pro Gly Gly Arg Ser Glu Glu Lys Ile 
             260                265                270
Ser Asp Ser Glu Gly Phe Lys Ala Asn Leu Ser Leu Leu Arg Arg Pro 
         275                280                285
Gly Glu Lys Thr Tyr Thr Gln Arg Cys Arg Leu Phe Val Gly Asn Leu 
     290                295                300
Pro Ala Asp Ile Thr Glu Asp Glu Phe Lys Arg Leu Phe Ala Lys Tyr 
 305                310                315                320
Gly Glu Pro Gly Glu Val Phe Ile Asn Lys Gly Lys Gly Phe Gly Phe 
                 325                330                335
Ile Lys Leu Glu Ser Arg Ala Leu Ala Glu Ile Ala Lys Ala Glu Leu 
             340                345                350
Asp Asp Thr Pro Met Arg Gly Arg Gln Leu Arg Val Arg Phe Ala Thr 
         355                360                365
His Ala Ala Ala Leu Ser Val Arg Asn Leu Ser Pro Tyr Val Ser Asn 
     370                375                380
Glu Leu Leu Glu Glu Ala Phe Ser Gln Phe Gly Pro Ile Glu Arg Ala 
 385                390                395                400
Val Val Ile Val Asp Asp Arg Gly Arg Ser Thr Gly Lys Gly Ile Val 
                 405                410                415
Glu Phe Ala Ser Lys Pro Ala Ala Arg Lys Ala Phe Glu Arg Cys Ser 
             420                425                430
Glu Gly Val Phe Leu Leu Thr Thr Thr Pro Arg Pro Val Ile Val Glu 
         435                440                445
Pro Leu Glu Gln Leu Asp Asp Glu Asp Gly Leu Pro Glu Lys Leu Ala 
     450                455                460
Gln Lys Asn Pro Met Tyr Gln Lys Glu Arg Glu Thr Pro Pro Arg Phe 
 465                470                475                480
Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr Ser Gln Arg Trp Lys Ser 
                 485                490                495
Leu Asp Glu Met Glu Lys Gln Gln Arg Glu Gln Val Glu Lys Asn Met 
             500                505                510
Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu Met Glu Asp Ala Tyr His 
         515                520                525
Glu His Gln Ala Asn Leu Leu Arg Gln Asp Leu Met Arg Arg Gln Glu 
     530                535                540
Glu Leu Arg Arg Met Glu Glu Leu His Asn Gln Glu Met Gln Lys Arg 
 545                550                555                560
Lys Glu Met Gln Leu Arg Gln Glu Glu Glu Arg Arg Arg Arg Glu Glu 
                 565                570                575
Glu Met Met Ile Arg Gln Arg Glu Met Glu Glu Gln Met Arg Arg Gln 
             580                585                590
Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr Met Asp Pro Arg Glu Arg 
         595                600                605
Asp Met Arg Met Gly Gly Gly Gly Ala Met Asn Met Gly Asp Pro Tyr 
     610                615                620
Gly Ser Gly Gly Gln Lys Phe Pro Pro Leu Gly Gly Gly Gly Gly Ile 
 625                630                635                640
Gly Tyr Glu Ala Asn Pro Gly Val Pro Pro Ala Thr Met Ser Gly Ser 
                 645                650                655
Met Met Gly Ser Asp Met Arg Thr Glu Arg Phe Gly Gln Gly Gly Ala 
             660                665                670
Gly Pro Val Gly Gly Gln Gly Pro Arg Gly Met Gly Pro Gly Thr Pro 
         675                680                685
Ala Gly Tyr Gly Arg Gly Arg Glu Glu Tyr Glu Gly Pro Asn Lys Lys 
     690                695                700
Pro Arg Phe 
 705



<210> 747
<211> 1039
<212> DNA
<213> Rattus norvegicus
<308> AF036335
<400> 747

gaaacgcct  ctcgttttg  tcagcatgg  acatttgag  atgaatatt  tcaacgatg  60
aagtctttg  atgaaatgg  aaaacagca  agggaacaa  ttgaaaaaa  catgaagga  120
gcaaaagac  agttggaaa  tgaaatgga  gatgcctac  atgaacacc  agcaaatct  180
ttgcgccaa  atctgatga  acgccagga  gaattaagg  gcatggagg  acttcacag  240
caagaaatg  agaaacgta  agaaatgca  ttgaggcaa  aggaggaac  gcgtacaag  300
gaggaagag  tgatgattc  ccaacgtga  atggaagaa  aaatgagac  ccaacgaga  360
gaaagctac  gcaggatgg  ctacatgga  cccaagaga  agagacatg  gaatgggtg  420
tggtggaac  atgaacatg  gagatccct  tggttcagg  ggccagaaa  ttccaccgc  480
aggtggtgg  ggtggcata  gttatgaag  taatcctgg  gttccacca  caaccatga  540
tggttccat  atgggaagc  acatgcgta  tgagcgctt  gggcaggga  gtgcgggtc  600
tgtgggtgg  cagggtcct  gaggaatgg  gcctggaac  ccagcagga  atggtagag  660
gagagaaga  tatgaaggg  caaataaaa  accccgatt  tagatactt  ggctttcat  720
ccagtttgg  tttgtcttc  tgtttagat  ccacttaaa  tcttggcat  ttagtaaga  780
agctacctt  ttatggatg  tagcagttt  ttgacctga  atttgtaaa  ggcctgttt  840
ggcaggtaa  attatgtaa  gcagtgttc  aaacaggag  aaaattttt  catttactt  900
ttttttaac  gtataatgt  tctcaagtt  atggcagtg  accttgtgc  actgaattt  960
caaagtgta  cattttttt  ttactgtgc  tcaaataaa  agaaaaaaa  agttatgaa  1020
aaaaaaaaa  aaaaaaaaa  1039



<210> 748
<211> 168
<212> PRT
<213> Rattus norvegicus
<308> AAD05362
<400> 748

Glu Thr Pro Pro Arg Phe Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr 
  1               5                  10                  15
Ser Gln Arg Trp Lys Ser Leu Asp Glu Met Glu Lys Gln Gln Arg Glu 
             20                  25                  30
Gln Val Glu Lys Asn Met Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu 
         35                  40                  45
Met Glu Asp Ala Tyr His Glu His Gln Ala Asn Leu Leu Arg Gln Asp 
     50                  55                  60
Leu Met Arg Arg Gln Glu Glu Leu Arg Arg Met Glu Glu Leu His Ser 
 65                  70                  75                  80
Gln Glu Met Gln Lys Arg Lys Glu Met Gln Leu Arg Gln Glu Glu Glu 
                 85                  90                  95
Arg Arg Thr Arg Glu Glu Glu Met Met Ile Arg Gln Arg Glu Met Glu 
             100                105                110
Glu Gln Met Arg Arg Gln Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr 
         115                120                125
Met Asp Pro Lys Arg Lys Arg His Glu Asn Gly Trp Trp Trp Asn Asn 
     130                135                140
Glu His Gly Arg Ser Leu Trp Phe Arg Arg Pro Glu Ile Ser Thr Ala 
 145                150                155                160
Arg Trp Trp Trp Trp His Arg Leu 
                 165



<210> 749
<211> 707
<212> PRT
<213> Homo sapiens
<308> P23246
<400> 749

Met Ser Arg Asp Arg Phe Arg Ser Arg Gly Gly Gly Gly Gly Gly Phe 
  1               5                  10                  15
His Arg Arg Gly Gly Gly Gly Gly Arg Gly Gly Leu His Asp Phe Arg 
             20                  25                  30
Ser Pro Pro Pro Gly Met Gly Leu Asn Gln Asn Arg Gly Pro Met Gly 
         35                  40                  45
Pro Gly Pro Gly Gln Ser Gly Pro Lys Pro Pro Ile Pro Pro Pro Pro 
     50                  55                  60
Pro His Gln Gln Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Gln 
 65                  70                  75                  80
Gln Pro Pro Pro His Gln Pro Pro Pro His Pro Gln Pro His Gln Gln 
                 85                  90                  95
Gln Gln Pro Pro Pro Pro Pro Gln Asp Ser Ser Lys Pro Val Val Ala 
             100                105                110
Gln Gly Pro Gly Pro Ala Pro Gly Val Gly Ser Ala Pro Pro Ala Ser 
         115                120                125
Ser Ser Ala Pro Pro Ala Thr Pro Pro Thr Ser Gly Ala Pro Pro Gly 
     130                135                140
Ser Gly Pro Gly Pro Thr Pro Thr Pro Pro Pro Ala Val Thr Ser Ala 
 145                150                155                160
Pro Pro Gly Ala Pro Pro Pro Thr Pro Pro Ser Ser Gly Val Pro Thr 
                 165                170                175
Thr Pro Pro Gln Ala Gly Gly Pro Pro Pro Pro Pro Ala Ala Val Pro 
             180                185                190
Gly Pro Gly Pro Gly Pro Lys Gln Gly Pro Gly Pro Gly Gly Pro Lys 
         195                200                205
Gly Gly Lys Met Pro Gly Gly Pro Lys Pro Gly Gly Gly Pro Gly Leu 
     210                215                220
Ser Thr Pro Gly Gly His Pro Lys Pro Pro His Arg Gly Gly Gly Glu 
 225                230                235                240
Pro Arg Gly Gly Arg Gln His His Pro Pro Tyr His Gln Gln His His 
                 245                250                255
Gln Gly Pro Pro Pro Gly Gly Pro Gly Gly Arg Ser Glu Glu Lys Ile 
             260                265                270
Ser Asp Ser Glu Gly Phe Lys Ala Asn Leu Ser Leu Leu Arg Arg Pro 
         275                280                285
Gly Glu Lys Thr Tyr Thr Gln Arg Cys Arg Leu Phe Val Gly Asn Leu 
     290                295                300
Pro Ala Asp Ile Thr Glu Asp Glu Phe Lys Arg Leu Phe Ala Lys Tyr 
 305                310                315                320
Gly Glu Pro Gly Glu Val Phe Ile Asn Lys Gly Lys Gly Phe Gly Phe 
                 325                330                335
Ile Lys Leu Glu Ser Arg Ala Leu Ala Glu Ile Ala Lys Ala Glu Leu 
             340                345                350
Asp Asp Thr Pro Met Arg Gly Arg Gln Leu Arg Val Arg Phe Ala Thr 
         355                360                365
His Ala Ala Ala Leu Ser Val Arg Asn Leu Ser Pro Tyr Val Ser Asn 
     370                375                380
Glu Leu Leu Glu Glu Ala Phe Ser Gln Phe Gly Pro Ile Glu Arg Ala 
 385                390                395                400
Val Val Ile Val Asp Asp Arg Gly Arg Ser Thr Gly Lys Gly Ile Val 
                 405                410                415
Glu Phe Ala Ser Lys Pro Ala Ala Arg Lys Ala Phe Glu Arg Cys Ser 
             420                425                430
Glu Gly Val Phe Leu Leu Thr Thr Thr Pro Arg Pro Val Ile Val Glu 
         435                440                445
Pro Leu Glu Gln Leu Asp Asp Glu Asp Gly Leu Pro Glu Lys Leu Ala 
     450                455                460
Gln Lys Asn Pro Met Tyr Gln Lys Glu Arg Glu Thr Pro Pro Arg Phe 
 465                470                475                480
Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr Ser Gln Arg Trp Lys Ser 
                 485                490                495
Leu Asp Glu Met Glu Lys Gln Gln Arg Glu Gln Val Glu Lys Asn Met 
             500                505                510
Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu Met Glu Asp Ala Tyr His 
         515                520                525
Glu His Gln Ala Asn Leu Leu Arg Gln Asp Leu Met Arg Arg Gln Glu 
     530                535                540
Glu Leu Arg Arg Met Glu Glu Leu His Asn Gln Glu Met Gln Lys Arg 
 545                550                555                560
Lys Glu Met Gln Leu Arg Gln Glu Glu Glu Arg Arg Arg Arg Glu Glu 
                 565                570                575
Glu Met Met Ile Arg Gln Arg Glu Met Glu Glu Gln Met Arg Arg Gln 
             580                585                590
Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr Met Asp Pro Arg Glu Arg 
         595                600                605
Asp Met Arg Met Gly Gly Gly Gly Ala Met Asn Met Gly Asp Pro Tyr 
     610                615                620
Gly Ser Gly Gly Gln Lys Phe Pro Pro Leu Gly Gly Gly Gly Gly Ile 
 625                630                635                640
Gly Tyr Glu Ala Asn Pro Gly Val Pro Pro Ala Thr Met Ser Gly Ser 
                 645                650                655
Met Met Gly Ser Asp Met Arg Thr Glu Arg Phe Gly Gln Gly Gly Ala 
             660                665                670
Gly Pro Val Gly Gly Gln Gly Pro Arg Gly Met Gly Pro Gly Thr Pro 
         675                680                685
Ala Gly Tyr Gly Arg Gly Arg Glu Glu Tyr Glu Gly Pro Asn Lys Lys 
     690                695                700
Pro Arg Phe 
 705



<210> 750
<211> 1039
<212> DNA
<213> Rattus norvegicus
<308> AF036335
<400> 750

gaaacgcct  ctcgttttg  tcagcatgg  acatttgag  atgaatatt  tcaacgatg  60
aagtctttg  atgaaatgg  aaaacagca  agggaacaa  ttgaaaaaa  catgaagga  120
gcaaaagac  agttggaaa  tgaaatgga  gatgcctac  atgaacacc  agcaaatct  180
ttgcgccaa  atctgatga  acgccagga  gaattaagg  gcatggagg  acttcacag  240
caagaaatg  agaaacgta  agaaatgca  ttgaggcaa  aggaggaac  gcgtacaag  300
gaggaagag  tgatgattc  ccaacgtga  atggaagaa  aaatgagac  ccaacgaga  360
gaaagctac  gcaggatgg  ctacatgga  cccaagaga  agagacatg  gaatgggtg  420
tggtggaac  atgaacatg  gagatccct  tggttcagg  ggccagaaa  ttccaccgc  480
aggtggtgg  ggtggcata  gttatgaag  taatcctgg  gttccacca  caaccatga  540
tggttccat  atgggaagc  acatgcgta  tgagcgctt  gggcaggga  gtgcgggtc  600
tgtgggtgg  cagggtcct  gaggaatgg  gcctggaac  ccagcagga  atggtagag  660
gagagaaga  tatgaaggg  caaataaaa  accccgatt  tagatactt  ggctttcat  720
ccagtttgg  tttgtcttc  tgtttagat  ccacttaaa  tcttggcat  ttagtaaga  780
agctacctt  ttatggatg  tagcagttt  ttgacctga  atttgtaaa  ggcctgttt  840
ggcaggtaa  attatgtaa  gcagtgttc  aaacaggag  aaaattttt  catttactt  900
ttttttaac  gtataatgt  tctcaagtt  atggcagtg  accttgtgc  actgaattt  960
caaagtgta  cattttttt  ttactgtgc  tcaaataaa  agaaaaaaa  agttatgaa  1020
aaaaaaaaa  aaaaaaaaa  1039



<210> 751
<211> 168
<212> PRT
<213> Rattus norvegicus
<308> AAD05362
<400> 751

Glu Thr Pro Pro Arg Phe Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr 
  1               5                  10                  15
Ser Gln Arg Trp Lys Ser Leu Asp Glu Met Glu Lys Gln Gln Arg Glu 
             20                  25                  30
Gln Val Glu Lys Asn Met Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu 
         35                  40                  45
Met Glu Asp Ala Tyr His Glu His Gln Ala Asn Leu Leu Arg Gln Asp 
     50                  55                  60
Leu Met Arg Arg Gln Glu Glu Leu Arg Arg Met Glu Glu Leu His Ser 
 65                  70                  75                  80
Gln Glu Met Gln Lys Arg Lys Glu Met Gln Leu Arg Gln Glu Glu Glu 
                 85                  90                  95
Arg Arg Thr Arg Glu Glu Glu Met Met Ile Arg Gln Arg Glu Met Glu 
             100                105                110
Glu Gln Met Arg Arg Gln Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr 
         115                120                125
Met Asp Pro Lys Arg Lys Arg His Glu Asn Gly Trp Trp Trp Asn Asn 
     130                135                140
Glu His Gly Arg Ser Leu Trp Phe Arg Arg Pro Glu Ile Ser Thr Ala 
 145                150                155                160
Arg Trp Trp Trp Trp His Arg Leu 
                 165



<210> 752
<211> 707
<212> PRT
<213> Homo sapiens
<308> P23246
<400> 752

Met Ser Arg Asp Arg Phe Arg Ser Arg Gly Gly Gly Gly Gly Gly Phe 
  1               5                  10                  15
His Arg Arg Gly Gly Gly Gly Gly Arg Gly Gly Leu His Asp Phe Arg 
             20                  25                  30
Ser Pro Pro Pro Gly Met Gly Leu Asn Gln Asn Arg Gly Pro Met Gly 
         35                  40                  45
Pro Gly Pro Gly Gln Ser Gly Pro Lys Pro Pro Ile Pro Pro Pro Pro 
     50                  55                  60
Pro His Gln Gln Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Gln 
 65                  70                  75                  80
Gln Pro Pro Pro His Gln Pro Pro Pro His Pro Gln Pro His Gln Gln 
                 85                  90                  95
Gln Gln Pro Pro Pro Pro Pro Gln Asp Ser Ser Lys Pro Val Val Ala 
             100                105                110
Gln Gly Pro Gly Pro Ala Pro Gly Val Gly Ser Ala Pro Pro Ala Ser 
         115                120                125
Ser Ser Ala Pro Pro Ala Thr Pro Pro Thr Ser Gly Ala Pro Pro Gly 
     130                135                140
Ser Gly Pro Gly Pro Thr Pro Thr Pro Pro Pro Ala Val Thr Ser Ala 
 145                150                155                160
Pro Pro Gly Ala Pro Pro Pro Thr Pro Pro Ser Ser Gly Val Pro Thr 
                 165                170                175
Thr Pro Pro Gln Ala Gly Gly Pro Pro Pro Pro Pro Ala Ala Val Pro 
             180                185                190
Gly Pro Gly Pro Gly Pro Lys Gln Gly Pro Gly Pro Gly Gly Pro Lys 
         195                200                205
Gly Gly Lys Met Pro Gly Gly Pro Lys Pro Gly Gly Gly Pro Gly Leu 
     210                215                220
Ser Thr Pro Gly Gly His Pro Lys Pro Pro His Arg Gly Gly Gly Glu 
 225                230                235                240
Pro Arg Gly Gly Arg Gln His His Pro Pro Tyr His Gln Gln His His 
                 245                250                255
Gln Gly Pro Pro Pro Gly Gly Pro Gly Gly Arg Ser Glu Glu Lys Ile 
             260                265                270
Ser Asp Ser Glu Gly Phe Lys Ala Asn Leu Ser Leu Leu Arg Arg Pro 
         275                280                285
Gly Glu Lys Thr Tyr Thr Gln Arg Cys Arg Leu Phe Val Gly Asn Leu 
     290                295                300
Pro Ala Asp Ile Thr Glu Asp Glu Phe Lys Arg Leu Phe Ala Lys Tyr 
 305                310                315                320
Gly Glu Pro Gly Glu Val Phe Ile Asn Lys Gly Lys Gly Phe Gly Phe 
                 325                330                335
Ile Lys Leu Glu Ser Arg Ala Leu Ala Glu Ile Ala Lys Ala Glu Leu 
             340                345                350
Asp Asp Thr Pro Met Arg Gly Arg Gln Leu Arg Val Arg Phe Ala Thr 
         355                360                365
His Ala Ala Ala Leu Ser Val Arg Asn Leu Ser Pro Tyr Val Ser Asn 
     370                375                380
Glu Leu Leu Glu Glu Ala Phe Ser Gln Phe Gly Pro Ile Glu Arg Ala 
 385                390                395                400
Val Val Ile Val Asp Asp Arg Gly Arg Ser Thr Gly Lys Gly Ile Val 
                 405                410                415
Glu Phe Ala Ser Lys Pro Ala Ala Arg Lys Ala Phe Glu Arg Cys Ser 
             420                425                430
Glu Gly Val Phe Leu Leu Thr Thr Thr Pro Arg Pro Val Ile Val Glu 
         435                440                445
Pro Leu Glu Gln Leu Asp Asp Glu Asp Gly Leu Pro Glu Lys Leu Ala 
     450                455                460
Gln Lys Asn Pro Met Tyr Gln Lys Glu Arg Glu Thr Pro Pro Arg Phe 
 465                470                475                480
Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr Ser Gln Arg Trp Lys Ser 
                 485                490                495
Leu Asp Glu Met Glu Lys Gln Gln Arg Glu Gln Val Glu Lys Asn Met 
             500                505                510
Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu Met Glu Asp Ala Tyr His 
         515                520                525
Glu His Gln Ala Asn Leu Leu Arg Gln Asp Leu Met Arg Arg Gln Glu 
     530                535                540
Glu Leu Arg Arg Met Glu Glu Leu His Asn Gln Glu Met Gln Lys Arg 
 545                550                555                560
Lys Glu Met Gln Leu Arg Gln Glu Glu Glu Arg Arg Arg Arg Glu Glu 
                 565                570                575
Glu Met Met Ile Arg Gln Arg Glu Met Glu Glu Gln Met Arg Arg Gln 
             580                585                590
Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr Met Asp Pro Arg Glu Arg 
         595                600                605
Asp Met Arg Met Gly Gly Gly Gly Ala Met Asn Met Gly Asp Pro Tyr 
     610                615                620
Gly Ser Gly Gly Gln Lys Phe Pro Pro Leu Gly Gly Gly Gly Gly Ile 
 625                630                635                640
Gly Tyr Glu Ala Asn Pro Gly Val Pro Pro Ala Thr Met Ser Gly Ser 
                 645                650                655
Met Met Gly Ser Asp Met Arg Thr Glu Arg Phe Gly Gln Gly Gly Ala 
             660                665                670
Gly Pro Val Gly Gly Gln Gly Pro Arg Gly Met Gly Pro Gly Thr Pro 
         675                680                685
Ala Gly Tyr Gly Arg Gly Arg Glu Glu Tyr Glu Gly Pro Asn Lys Lys 
     690                695                700
Pro Arg Phe 
 705



<210> 753
<211> 1039
<212> DNA
<213> Rattus norvegicus
<308> AF036335
<400> 753

gaaacgcct  ctcgttttg  tcagcatgg  acatttgag  atgaatatt  tcaacgatg  60
aagtctttg  atgaaatgg  aaaacagca  agggaacaa  ttgaaaaaa  catgaagga  120
gcaaaagac  agttggaaa  tgaaatgga  gatgcctac  atgaacacc  agcaaatct  180
ttgcgccaa  atctgatga  acgccagga  gaattaagg  gcatggagg  acttcacag  240
caagaaatg  agaaacgta  agaaatgca  ttgaggcaa  aggaggaac  gcgtacaag  300
gaggaagag  tgatgattc  ccaacgtga  atggaagaa  aaatgagac  ccaacgaga  360
gaaagctac  gcaggatgg  ctacatgga  cccaagaga  agagacatg  gaatgggtg  420
tggtggaac  atgaacatg  gagatccct  tggttcagg  ggccagaaa  ttccaccgc  480
aggtggtgg  ggtggcata  gttatgaag  taatcctgg  gttccacca  caaccatga  540
tggttccat  atgggaagc  acatgcgta  tgagcgctt  gggcaggga  gtgcgggtc  600
tgtgggtgg  cagggtcct  gaggaatgg  gcctggaac  ccagcagga  atggtagag  660
gagagaaga  tatgaaggg  caaataaaa  accccgatt  tagatactt  ggctttcat  720
ccagtttgg  tttgtcttc  tgtttagat  ccacttaaa  tcttggcat  ttagtaaga  780
agctacctt  ttatggatg  tagcagttt  ttgacctga  atttgtaaa  ggcctgttt  840
ggcaggtaa  attatgtaa  gcagtgttc  aaacaggag  aaaattttt  catttactt  900
ttttttaac  gtataatgt  tctcaagtt  atggcagtg  accttgtgc  actgaattt  960
caaagtgta  cattttttt  ttactgtgc  tcaaataaa  agaaaaaaa  agttatgaa  1020
aaaaaaaaa  aaaaaaaaa  1039



<210> 754
<211> 168
<212> PRT
<213> Rattus norvegicus
<308> AAD05362
<400> 754

Glu Thr Pro Pro Arg Phe Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr 
  1               5                  10                  15
Ser Gln Arg Trp Lys Ser Leu Asp Glu Met Glu Lys Gln Gln Arg Glu 
             20                  25                  30
Gln Val Glu Lys Asn Met Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu 
         35                  40                  45
Met Glu Asp Ala Tyr His Glu His Gln Ala Asn Leu Leu Arg Gln Asp 
     50                  55                  60
Leu Met Arg Arg Gln Glu Glu Leu Arg Arg Met Glu Glu Leu His Ser 
 65                  70                  75                  80
Gln Glu Met Gln Lys Arg Lys Glu Met Gln Leu Arg Gln Glu Glu Glu 
                 85                  90                  95
Arg Arg Thr Arg Glu Glu Glu Met Met Ile Arg Gln Arg Glu Met Glu 
             100                105                110
Glu Gln Met Arg Arg Gln Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr 
         115                120                125
Met Asp Pro Lys Arg Lys Arg His Glu Asn Gly Trp Trp Trp Asn Asn 
     130                135                140
Glu His Gly Arg Ser Leu Trp Phe Arg Arg Pro Glu Ile Ser Thr Ala 
 145                150                155                160
Arg Trp Trp Trp Trp His Arg Leu 
                 165



<210> 755
<211> 707
<212> PRT
<213> Homo sapiens
<308> P23246
<400> 755

Met Ser Arg Asp Arg Phe Arg Ser Arg Gly Gly Gly Gly Gly Gly Phe 
  1               5                  10                  15
His Arg Arg Gly Gly Gly Gly Gly Arg Gly Gly Leu His Asp Phe Arg 
             20                  25                  30
Ser Pro Pro Pro Gly Met Gly Leu Asn Gln Asn Arg Gly Pro Met Gly 
         35                  40                  45
Pro Gly Pro Gly Gln Ser Gly Pro Lys Pro Pro Ile Pro Pro Pro Pro 
     50                  55                  60
Pro His Gln Gln Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Gln 
 65                  70                  75                  80
Gln Pro Pro Pro His Gln Pro Pro Pro His Pro Gln Pro His Gln Gln 
                 85                  90                  95
Gln Gln Pro Pro Pro Pro Pro Gln Asp Ser Ser Lys Pro Val Val Ala 
             100                105                110
Gln Gly Pro Gly Pro Ala Pro Gly Val Gly Ser Ala Pro Pro Ala Ser 
         115                120                125
Ser Ser Ala Pro Pro Ala Thr Pro Pro Thr Ser Gly Ala Pro Pro Gly 
     130                135                140
Ser Gly Pro Gly Pro Thr Pro Thr Pro Pro Pro Ala Val Thr Ser Ala 
 145                150                155                160
Pro Pro Gly Ala Pro Pro Pro Thr Pro Pro Ser Ser Gly Val Pro Thr 
                 165                170                175
Thr Pro Pro Gln Ala Gly Gly Pro Pro Pro Pro Pro Ala Ala Val Pro 
             180                185                190
Gly Pro Gly Pro Gly Pro Lys Gln Gly Pro Gly Pro Gly Gly Pro Lys 
         195                200                205
Gly Gly Lys Met Pro Gly Gly Pro Lys Pro Gly Gly Gly Pro Gly Leu 
     210                215                220
Ser Thr Pro Gly Gly His Pro Lys Pro Pro His Arg Gly Gly Gly Glu 
 225                230                235                240
Pro Arg Gly Gly Arg Gln His His Pro Pro Tyr His Gln Gln His His 
                 245                250                255
Gln Gly Pro Pro Pro Gly Gly Pro Gly Gly Arg Ser Glu Glu Lys Ile 
             260                265                270
Ser Asp Ser Glu Gly Phe Lys Ala Asn Leu Ser Leu Leu Arg Arg Pro 
         275                280                285
Gly Glu Lys Thr Tyr Thr Gln Arg Cys Arg Leu Phe Val Gly Asn Leu 
     290                295                300
Pro Ala Asp Ile Thr Glu Asp Glu Phe Lys Arg Leu Phe Ala Lys Tyr 
 305                310                315                320
Gly Glu Pro Gly Glu Val Phe Ile Asn Lys Gly Lys Gly Phe Gly Phe 
                 325                330                335
Ile Lys Leu Glu Ser Arg Ala Leu Ala Glu Ile Ala Lys Ala Glu Leu 
             340                345                350
Asp Asp Thr Pro Met Arg Gly Arg Gln Leu Arg Val Arg Phe Ala Thr 
         355                360                365
His Ala Ala Ala Leu Ser Val Arg Asn Leu Ser Pro Tyr Val Ser Asn 
     370                375                380
Glu Leu Leu Glu Glu Ala Phe Ser Gln Phe Gly Pro Ile Glu Arg Ala 
 385                390                395                400
Val Val Ile Val Asp Asp Arg Gly Arg Ser Thr Gly Lys Gly Ile Val 
                 405                410                415
Glu Phe Ala Ser Lys Pro Ala Ala Arg Lys Ala Phe Glu Arg Cys Ser 
             420                425                430
Glu Gly Val Phe Leu Leu Thr Thr Thr Pro Arg Pro Val Ile Val Glu 
         435                440                445
Pro Leu Glu Gln Leu Asp Asp Glu Asp Gly Leu Pro Glu Lys Leu Ala 
     450                455                460
Gln Lys Asn Pro Met Tyr Gln Lys Glu Arg Glu Thr Pro Pro Arg Phe 
 465                470                475                480
Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr Ser Gln Arg Trp Lys Ser 
                 485                490                495
Leu Asp Glu Met Glu Lys Gln Gln Arg Glu Gln Val Glu Lys Asn Met 
             500                505                510
Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu Met Glu Asp Ala Tyr His 
         515                520                525
Glu His Gln Ala Asn Leu Leu Arg Gln Asp Leu Met Arg Arg Gln Glu 
     530                535                540
Glu Leu Arg Arg Met Glu Glu Leu His Asn Gln Glu Met Gln Lys Arg 
 545                550                555                560
Lys Glu Met Gln Leu Arg Gln Glu Glu Glu Arg Arg Arg Arg Glu Glu 
                 565                570                575
Glu Met Met Ile Arg Gln Arg Glu Met Glu Glu Gln Met Arg Arg Gln 
             580                585                590
Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr Met Asp Pro Arg Glu Arg 
         595                600                605
Asp Met Arg Met Gly Gly Gly Gly Ala Met Asn Met Gly Asp Pro Tyr 
     610                615                620
Gly Ser Gly Gly Gln Lys Phe Pro Pro Leu Gly Gly Gly Gly Gly Ile 
 625                630                635                640
Gly Tyr Glu Ala Asn Pro Gly Val Pro Pro Ala Thr Met Ser Gly Ser 
                 645                650                655
Met Met Gly Ser Asp Met Arg Thr Glu Arg Phe Gly Gln Gly Gly Ala 
             660                665                670
Gly Pro Val Gly Gly Gln Gly Pro Arg Gly Met Gly Pro Gly Thr Pro 
         675                680                685
Ala Gly Tyr Gly Arg Gly Arg Glu Glu Tyr Glu Gly Pro Asn Lys Lys 
     690                695                700
Pro Arg Phe 
 705



<210> 756
<211> 639
<212> DNA
<213> Rattus norvegicus
<308> AF036761
<400> 756

cggctgccc  tgaggctct  tctcatcat  gccaacacc  tggcattcc  gaacgatgt  60
tacgaatgg  cccgggatc  ccgcgccca  cacaagttc  cagagacac  cgccgaccc  120
cacaactcc  gccgtggct  tttcttctc  cacgtgggt  ggctgcttg  gcgcaaaca  180
ccggctgtc  aagagaagg  cggaaagct  gacatgtct  acctgaaag  tgagaagct  240
gtgatgttc  agaggaggt  ttacaagcc  ggcctcctg  tcatgtgct  catcctgcc  300
acgctggtg  cctggtact  ctggggtga  acgtttgta  acagcctgt  cgtcagcac  360
ttcttacgg  acgctgtgg  gctcaacgc  acctggctg  tgaacagcg  cgcccacct  420
tatggatat  gcccctacg  caagaacat  agctctcgg  agaacatcc  ggtgtcgat  480
ggagctgtg  gcgagggct  ccacaacta  catcacgcc  tcccctatg  ctactctgc  540
agtgagtac  gctggcaca  caacttcac  acgttcttc  tcgactgca  ggccctcct  600
ggcctggct  atgaccgga  gagggtgtc  aaggccgct  639



<210> 757
<211> 213
<212> PRT
<213> Rattus norvegicus
<308> AAB88865
<400> 757

Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met Ala Phe 
  1               5                  10                  15
Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His His Lys 
             20                  25                  30
Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly Phe Phe 
         35                  40                  45
Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala Val Lys 
     50                  55                  60
Glu Lys Gly Gly Lys Leu Asp Met Ser Asp Leu Lys Ala Glu Lys Leu 
 65                  70                  75                  80
Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Leu Met Cys 
                 85                  90                  95
Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Cys Trp Gly Glu Thr Phe 
             100                105                110
Val Asn Ser Leu Cys Val Ser Thr Phe Leu Arg Tyr Ala Val Val Leu 
         115                120                125
Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Tyr Gly Tyr Arg 
     130                135                140
Pro Tyr Asp Lys Asn Ile Ser Ser Arg Glu Asn Ile Leu Val Ser Met 
 145                150                155                160
Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ala Phe Pro Tyr 
                 165                170                175
Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr Thr Phe 
             180                185                190
Phe Ile Asp Cys Met Ala Leu Leu Gly Leu Ala Tyr Asp Arg Lys Arg 
         195                200                205
Val Ser Lys Ala Ala 
     210



<210> 758
<211> 5221
<212> DNA
<213> Homo sapiens
<308> AF097514
<400> 758

ataaaaggg  gctgaggaa  taccggaca  ggtcacccg  tgccagctc  agcctttaa  60
ttcccggct  ggggacctc  acgcaccgc  gctagcgcc  acaaccagc  agcgtgcaa  120
gcgccgcgg  tcagcgcgt  ccggcgggc  tcgaaaccg  agtcctccg  cgaccccga  180
ctccgctcc  gagcctcag  cccctggaa  gtgatcccg  catccgaga  ccaagatgc  240
ggcccactt  ctgcaggac  atatctcta  ctcctatac  accaccacc  ccattacag  300
gcctccctc  agggtcctg  agaatggag  agataagtt  gagacgatg  ccctctact  360
ggaagacga  attcgccct  atataaaag  tgatatata  gaccccacc  acaaggata  420
ggaaggccc  agccccaag  ttgaatatg  ctggagaaa  atcatcctt  tgtctctgc  480
acacttggg  gccctgtat  ggatcactt  gattcctac  tgcaagttc  acacctggc  540
ttggggggt  ttctactat  ttgtcagtg  cctgggcat  acagcagga  ctcatcgtc  600
gtggagcca  cgctcttac  aagctcggc  gcccctacg  ctctttctg  tcattgcca  660
cacaatggc  ttccagaat  atgtctatg  atgggctcg  gaccaccgt  cccaccaca  720
gttttcaga  acacatgct  atcctcata  ttcccgacg  ggctttttc  tctctcacg  780
gggttggct  cttgtgcgc  aacacccag  tgtcaaaga  aaggggagt  cgctagact  840
gtctgacct  gaagctgag  aactggtga  gttccagag  aggtactac  aacctggct  900
gctgctgat  tgcttcatc  tgcccacgc  tgtgccctg  tatttctgg  gtgaaactt  960
tcaaaacag  gtgttcgtt  ccactttct  gcgatatgc  gtggtgctt  atgccacct  1020
gctggtgaa  agtgctgcc  acctcttcg  atatcgtcc  tatgacaag  acattagcc  1080
ccgggagaa  atcctggtt  cacttggag  tgtgggtga  ggcttccac  actaccacc  1140
ctcctttcc  tatgactac  ctgccagtg  gtaccgctg  cacatcaac  tcaccacat  1200
cttcattga  tgcatggcc  ccctcggtc  ggcctatga  cggaagaaa  tctccaagg  1260
cgccatctt  gccaggatt  aaagaaccg  agatggaaa  tacaagagt  gctgagttt  1320
gggtccctc  ggtttcctt  ttcaaaaac  agccaggca  aggttttaa  gtctgttta  1380
taactactg  ataatgcta  caggatgct  aagatgatg  tgttaaccc  ttccagtac  1440
gtattcttt  aaaattcaa  agtattgaa  gccaacaac  ctgccttta  gatgctaag  1500
tgatattat  tcttctctt  tcctctctc  cttctaggc  cattgtcct  cttttcact  1560
tattgctat  gccctcctt  cccttattg  ctcccaggc  agcagctgg  cagtctttg  1620
tcagtgtcc  gcttccaaa  cctagacaa  ctttctgta  cctaaaacg  atggtcttt  1680
ctccagata  ctctctttc  ttgagctgt  gtgagcttt  aagtaggtg  cttgagcta  1740
agataaaac  gaatcttct  ggtagtccc  tgttgatta  cttcagccc  ggcttttgc  1800
agatggaat  gaaaagcaa  ttcatttga  acaaagctt  taaagcagg  aaattgtcg  1860
gggagagag  tagcatgta  gaatgtaag  atgagggaa  cgaagcaag  ggaacctct  1920
gccatgatc  gacatacag  tgcctacct  atgaggact  caagcccca  cacatagca  1980
gcttccttt  tctcctggc  cggggtaaa  agtggctgc  gtgtttggc  atgctaatt  2040
aatgccgca  catatagtt  aggccgagg  taaagaaaa  acattttaa  tttgtagta  2100
aagtggtct  tgctgggga  gggttttct  ttctttttt  ctttaataa  aaggagatt  2160
cttagttca  atatcaaga  gtcttgaag  tgggtgttt  cagaattgg  aaaaacagc  2220
gctcatgga  ttttgagta  tccatgagc  gctcattac  gttctttcc  ctttctgct  2280
tgccatctt  aggatattg  ttcttcccc  catagtaat  agatggctg  ggcatttcc  2340
aacatccaa  aaaagggaa  gatttaagg  ggtgaagtc  ggtcaaaaa  aaaatatat  2400
tacatatat  cattgctta  aacgttaaa  tattagagt  tttcccttc  aaagaggga  2460
gtttggaaa  aactctgaa  gagaggagg  attagttgg  atgccaatt  cctctccac  2520
gctggacat  agatggaga  gctgaggga  aggatctat  ggcagcttc  aagagcgaa  2580
ttcacatag  aagggatct  agaacacgt  gccaggggc  tgagaaggt  actgagtga  2640
ttattggga  tcttaataa  ataaactag  tattaggtc  attcattaa  tagttccag  2700
ttctccttg  aatgagtaa  aactagaag  cttctctcc  cagtgttgt  ccccttcac  2760
cattttttt  tgaggagaa  ggggtctct  ttaacatct  gcctaaagt  tacaactgc  2820
tggggggca  ggttaggaa  ctcttcact  ccctgattc  tgattcctg  ctctaccct  2880
tctgtccct  ttctttgac  agatctttc  cttccctga  cgttttctt  tttccctgg  2940
caggcagcc  cctttgtgt  tattcagag  cagtgatga  ttgctgtcc  ggcagctcc  3000
tcctgcaca  agaatgctc  gggtcactg  accactgct  ctcttttga  agtagagct  3060
gctgccact  tcacgtggc  tccgcagtg  ctccaccta  acccctgtg  tcccctgcc  3120
cactgatgg  tcaagacaa  gctggcaaa  cctcccaga  acatctctg  cccagaaag  3180
ctctctctc  ctccctctc  catgaggca  agccaagcc  agcgctcat  ttgagccag  3240
gggccagcc  cagagcaaa  gagggttta  tttcagtcc  ctctctctg  gtcagaacc  3300
gagggcatg  tgaatgccc  ctgcttact  ggtgagggt  ccccgcctg  gtcagtgct  3360
tcagctggc  gtgcaatgc  tgtagaagt  ggaggaaac  gttctcact  ggaagaagc  3420
agggcaaga  cccaagtgc  tcacctcga  aggaggccc  gttccctgg  gtcagggtg  3480
actgcaaag  tttggctga  acctgggat  tgagatacc  caaaccctg  tgaacacag  3540
gtctgttca  caaactaac  agcattccc  acagcctag  gcagacaat  gtatagaag  3600
ctggaaaaa  acaaaaaca  aatttgaga  ccttggacc  ctcctgtcc  tgtagctca  3660
tcatcaaag  agaagtctg  ctttgctct  ttaagattg  aaatgtaca  taccaaaca  3720
tcagtccac  gttgagccc  agtgctgga  gggaggaag  cctttcttc  gtgttaatt  3780
cgtagaggc  acaggggtt  gcctggact  aaggcatcc  tgtcttttg  gctattcac  3840
tcagtagaa  aggatctaa  ggaagatca  tgtagttta  ttctgttga  ctgtgcacc  3900
accccttgg  aatgtctgc  ggtatttct  attccacag  tcatcagat  cctgcttga  3960
aatatataa  caataaaaa  aactttcac  tcttcctat  gtaatcgtg  gccatggat  4020
tgatctgta  catgaccct  cataaggct  gatggcacc  caggctgag  gccccaatg  4080
atgtgtggc  gtgggtgtg  gtgggagtg  gtctgctga  taaggaaca  gattttcaa  4140
attctaaag  tcaattcaa  tgacacatt  atgataaac  cagatctga  caagagtcc  4200
gatttctaa  agtccctgc  ttggggggt  tgctgacaa  ttagctcag  tgccttaca  4260
cttttctaa  cacagtgtt  catatgagc  tgccctcac  ccctctgca  aatcccttt  4320
cacctgaga  cctactgaa  tggctggta  aaaaagggg  ctgagtgga  gattatcag  4380
atcacgatt  gcaggattc  cttctgggc  tcattctgg  aacttttgt  agggctgct  4440
ttcttaagt  cccacattt  atggagggt  gaaataatt  gaatgtatt  gatttataa  4500
ttttttttt  tttttgggt  aaaagatgg  tgtagcatt  aaaatggaa  attttctcc  4560
tggtttgct  gtatcttgg  tgtattctc  gtaagtgta  ctcaaatag  tcatcatga  4620
aggttaaaa  agcgaggtg  ccatgttat  ctggtggtt  aggccaggg  ctctccaac  4680
actgtgcca  tgacttgct  tgtgaccct  ggcaagtca  ttaactata  ggtgcctca  4740
ttttccttc  gttaaaatg  ggataataa  actgaccta  ctcaaaggg  agttttgag  4800
catgactaa  gctttttag  aagcatttt  ggatccttc  gcacaggaa  tctcaagac  4860
tgagtattt  ttataatag  aatgtccac  atgaacttg  tacgtccgt  tgtcccaga  4920
gctgtcatt  gtctatatg  ttctccaag  aactgaatg  atccattgg  gaagcggtg  4980
ataactagc  agacaaaat  tgagaatac  taaacaacg  attgccacg  aaacataca  5040
aggatgcct  ttctgtgat  gggtgggat  ttttccctt  ttatgtggg  tatagtagt  5100
acttgtgac  aaaataatt  tggaataat  tctattaat  tcaactctg  agctaattg  5160
actaatctg  gattgtgtt  gttcataat  aaagtgaag  gaatctaaa  aaaaaaaaa  5220
a  5221



<210> 759
<211> 359
<212> PRT
<213> Homo sapiens
<308> O00767
<400> 759

Met Pro Ala His Leu Leu Gln Asp Asp Ile Ser Ser Ser Tyr Thr Thr 
  1               5                  10                  15
Thr Thr Thr Ile Thr Ala Pro Pro Ser Arg Val Leu Gln Asn Gly Gly 
             20                  25                  30
Asp Lys Leu Glu Thr Met Pro Leu Tyr Leu Glu Asp Asp Ile Arg Pro 
         35                  40                  45
Asp Ile Lys Asp Asp Ile Tyr Asp Pro Thr Tyr Lys Asp Lys Glu Gly 
     50                  55                  60
Pro Ser Pro Lys Val Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ser 
 65                  70                  75                  80
Leu Leu His Leu Gly Ala Leu Tyr Gly Ile Thr Leu Ile Pro Thr Cys 
                 85                  90                  95
Lys Phe Tyr Thr Trp Leu Trp Gly Val Phe Tyr Tyr Phe Val Ser Ala 
             100                105                110
Leu Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Ser Tyr 
         115                120                125
Lys Ala Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met 
     130                135                140
Ala Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His 
 145                150                155                160
His Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly 
                 165                170                175
Phe Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala 
             180                185                190
Val Lys Glu Lys Gly Ser Thr Leu Asp Leu Ser Asp Leu Glu Ala Glu 
         195                200                205
Lys Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Met 
     210                215                220
Met Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Phe Trp Gly Glu 
 225                230                235                240
Thr Phe Gln Asn Ser Val Phe Val Ala Thr Phe Leu Arg Tyr Ala Val 
                 245                250                255
Val Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Phe Gly 
             260                265                270
Tyr Arg Pro Tyr Asp Lys Asn Ile Ser Pro Arg Glu Asn Ile Leu Val 
         275                280                285
Ser Leu Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ser Phe 
     290                295                300
Pro Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr 
 305                310                315                320
Thr Phe Phe Ile Asp Cys Met Ala Ala Leu Gly Leu Ala Tyr Asp Arg 
                 325                330                335
Lys Lys Val Ser Lys Ala Ala Ile Leu Ala Arg Ile Lys Arg Thr Gly 
             340                345                350
Asp Gly Asn Tyr Lys Ser Gly 
         355



<210> 760
<211> 639
<212> DNA
<213> Rattus norvegicus
<308> AF036761
<400> 760

cggctgccc  tgaggctct  tctcatcat  gccaacacc  tggcattcc  gaacgatgt  60
tacgaatgg  cccgggatc  ccgcgccca  cacaagttc  cagagacac  cgccgaccc  120
cacaactcc  gccgtggct  tttcttctc  cacgtgggt  ggctgcttg  gcgcaaaca  180
ccggctgtc  aagagaagg  cggaaagct  gacatgtct  acctgaaag  tgagaagct  240
gtgatgttc  agaggaggt  ttacaagcc  ggcctcctg  tcatgtgct  catcctgcc  300
acgctggtg  cctggtact  ctggggtga  acgtttgta  acagcctgt  cgtcagcac  360
ttcttacgg  acgctgtgg  gctcaacgc  acctggctg  tgaacagcg  cgcccacct  420
tatggatat  gcccctacg  caagaacat  agctctcgg  agaacatcc  ggtgtcgat  480
ggagctgtg  gcgagggct  ccacaacta  catcacgcc  tcccctatg  ctactctgc  540
agtgagtac  gctggcaca  caacttcac  acgttcttc  tcgactgca  ggccctcct  600
ggcctggct  atgaccgga  gagggtgtc  aaggccgct  639



<210> 761
<211> 213
<212> PRT
<213> Rattus norvegicus
<308> AAB88865
<400> 761

Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met Ala Phe 
  1               5                  10                  15
Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His His Lys 
             20                  25                  30
Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly Phe Phe 
         35                  40                  45
Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala Val Lys 
     50                  55                  60
Glu Lys Gly Gly Lys Leu Asp Met Ser Asp Leu Lys Ala Glu Lys Leu 
 65                  70                  75                  80
Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Leu Met Cys 
                 85                  90                  95
Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Cys Trp Gly Glu Thr Phe 
             100                105                110
Val Asn Ser Leu Cys Val Ser Thr Phe Leu Arg Tyr Ala Val Val Leu 
         115                120                125
Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Tyr Gly Tyr Arg 
     130                135                140
Pro Tyr Asp Lys Asn Ile Ser Ser Arg Glu Asn Ile Leu Val Ser Met 
 145                150                155                160
Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ala Phe Pro Tyr 
                 165                170                175
Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr Thr Phe 
             180                185                190
Phe Ile Asp Cys Met Ala Leu Leu Gly Leu Ala Tyr Asp Arg Lys Arg 
         195                200                205
Val Ser Lys Ala Ala 
     210



<210> 762
<211> 5221
<212> DNA
<213> Homo sapiens
<308> AF097514
<400> 762

ataaaaggg  gctgaggaa  taccggaca  ggtcacccg  tgccagctc  agcctttaa  60
ttcccggct  ggggacctc  acgcaccgc  gctagcgcc  acaaccagc  agcgtgcaa  120
gcgccgcgg  tcagcgcgt  ccggcgggc  tcgaaaccg  agtcctccg  cgaccccga  180
ctccgctcc  gagcctcag  cccctggaa  gtgatcccg  catccgaga  ccaagatgc  240
ggcccactt  ctgcaggac  atatctcta  ctcctatac  accaccacc  ccattacag  300
gcctccctc  agggtcctg  agaatggag  agataagtt  gagacgatg  ccctctact  360
ggaagacga  attcgccct  atataaaag  tgatatata  gaccccacc  acaaggata  420
ggaaggccc  agccccaag  ttgaatatg  ctggagaaa  atcatcctt  tgtctctgc  480
acacttggg  gccctgtat  ggatcactt  gattcctac  tgcaagttc  acacctggc  540
ttggggggt  ttctactat  ttgtcagtg  cctgggcat  acagcagga  ctcatcgtc  600
gtggagcca  cgctcttac  aagctcggc  gcccctacg  ctctttctg  tcattgcca  660
cacaatggc  ttccagaat  atgtctatg  atgggctcg  gaccaccgt  cccaccaca  720
gttttcaga  acacatgct  atcctcata  ttcccgacg  ggctttttc  tctctcacg  780
gggttggct  cttgtgcgc  aacacccag  tgtcaaaga  aaggggagt  cgctagact  840
gtctgacct  gaagctgag  aactggtga  gttccagag  aggtactac  aacctggct  900
gctgctgat  tgcttcatc  tgcccacgc  tgtgccctg  tatttctgg  gtgaaactt  960
tcaaaacag  gtgttcgtt  ccactttct  gcgatatgc  gtggtgctt  atgccacct  1020
gctggtgaa  agtgctgcc  acctcttcg  atatcgtcc  tatgacaag  acattagcc  1080
ccgggagaa  atcctggtt  cacttggag  tgtgggtga  ggcttccac  actaccacc  1140
ctcctttcc  tatgactac  ctgccagtg  gtaccgctg  cacatcaac  tcaccacat  1200
cttcattga  tgcatggcc  ccctcggtc  ggcctatga  cggaagaaa  tctccaagg  1260
cgccatctt  gccaggatt  aaagaaccg  agatggaaa  tacaagagt  gctgagttt  1320
gggtccctc  ggtttcctt  ttcaaaaac  agccaggca  aggttttaa  gtctgttta  1380
taactactg  ataatgcta  caggatgct  aagatgatg  tgttaaccc  ttccagtac  1440
gtattcttt  aaaattcaa  agtattgaa  gccaacaac  ctgccttta  gatgctaag  1500
tgatattat  tcttctctt  tcctctctc  cttctaggc  cattgtcct  cttttcact  1560
tattgctat  gccctcctt  cccttattg  ctcccaggc  agcagctgg  cagtctttg  1620
tcagtgtcc  gcttccaaa  cctagacaa  ctttctgta  cctaaaacg  atggtcttt  1680
ctccagata  ctctctttc  ttgagctgt  gtgagcttt  aagtaggtg  cttgagcta  1740
agataaaac  gaatcttct  ggtagtccc  tgttgatta  cttcagccc  ggcttttgc  1800
agatggaat  gaaaagcaa  ttcatttga  acaaagctt  taaagcagg  aaattgtcg  1860
gggagagag  tagcatgta  gaatgtaag  atgagggaa  cgaagcaag  ggaacctct  1920
gccatgatc  gacatacag  tgcctacct  atgaggact  caagcccca  cacatagca  1980
gcttccttt  tctcctggc  cggggtaaa  agtggctgc  gtgtttggc  atgctaatt  2040
aatgccgca  catatagtt  aggccgagg  taaagaaaa  acattttaa  tttgtagta  2100
aagtggtct  tgctgggga  gggttttct  ttctttttt  ctttaataa  aaggagatt  2160
cttagttca  atatcaaga  gtcttgaag  tgggtgttt  cagaattgg  aaaaacagc  2220
gctcatgga  ttttgagta  tccatgagc  gctcattac  gttctttcc  ctttctgct  2280
tgccatctt  aggatattg  ttcttcccc  catagtaat  agatggctg  ggcatttcc  2340
aacatccaa  aaaagggaa  gatttaagg  ggtgaagtc  ggtcaaaaa  aaaatatat  2400
tacatatat  cattgctta  aacgttaaa  tattagagt  tttcccttc  aaagaggga  2460
gtttggaaa  aactctgaa  gagaggagg  attagttgg  atgccaatt  cctctccac  2520
gctggacat  agatggaga  gctgaggga  aggatctat  ggcagcttc  aagagcgaa  2580
ttcacatag  aagggatct  agaacacgt  gccaggggc  tgagaaggt  actgagtga  2640
ttattggga  tcttaataa  ataaactag  tattaggtc  attcattaa  tagttccag  2700
ttctccttg  aatgagtaa  aactagaag  cttctctcc  cagtgttgt  ccccttcac  2760
cattttttt  tgaggagaa  ggggtctct  ttaacatct  gcctaaagt  tacaactgc  2820
tggggggca  ggttaggaa  ctcttcact  ccctgattc  tgattcctg  ctctaccct  2880
tctgtccct  ttctttgac  agatctttc  cttccctga  cgttttctt  tttccctgg  2940
caggcagcc  cctttgtgt  tattcagag  cagtgatga  ttgctgtcc  ggcagctcc  3000
tcctgcaca  agaatgctc  gggtcactg  accactgct  ctcttttga  agtagagct  3060
gctgccact  tcacgtggc  tccgcagtg  ctccaccta  acccctgtg  tcccctgcc  3120
cactgatgg  tcaagacaa  gctggcaaa  cctcccaga  acatctctg  cccagaaag  3180
ctctctctc  ctccctctc  catgaggca  agccaagcc  agcgctcat  ttgagccag  3240
gggccagcc  cagagcaaa  gagggttta  tttcagtcc  ctctctctg  gtcagaacc  3300
gagggcatg  tgaatgccc  ctgcttact  ggtgagggt  ccccgcctg  gtcagtgct  3360
tcagctggc  gtgcaatgc  tgtagaagt  ggaggaaac  gttctcact  ggaagaagc  3420
agggcaaga  cccaagtgc  tcacctcga  aggaggccc  gttccctgg  gtcagggtg  3480
actgcaaag  tttggctga  acctgggat  tgagatacc  caaaccctg  tgaacacag  3540
gtctgttca  caaactaac  agcattccc  acagcctag  gcagacaat  gtatagaag  3600
ctggaaaaa  acaaaaaca  aatttgaga  ccttggacc  ctcctgtcc  tgtagctca  3660
tcatcaaag  agaagtctg  ctttgctct  ttaagattg  aaatgtaca  taccaaaca  3720
tcagtccac  gttgagccc  agtgctgga  gggaggaag  cctttcttc  gtgttaatt  3780
cgtagaggc  acaggggtt  gcctggact  aaggcatcc  tgtcttttg  gctattcac  3840
tcagtagaa  aggatctaa  ggaagatca  tgtagttta  ttctgttga  ctgtgcacc  3900
accccttgg  aatgtctgc  ggtatttct  attccacag  tcatcagat  cctgcttga  3960
aatatataa  caataaaaa  aactttcac  tcttcctat  gtaatcgtg  gccatggat  4020
tgatctgta  catgaccct  cataaggct  gatggcacc  caggctgag  gccccaatg  4080
atgtgtggc  gtgggtgtg  gtgggagtg  gtctgctga  taaggaaca  gattttcaa  4140
attctaaag  tcaattcaa  tgacacatt  atgataaac  cagatctga  caagagtcc  4200
gatttctaa  agtccctgc  ttggggggt  tgctgacaa  ttagctcag  tgccttaca  4260
cttttctaa  cacagtgtt  catatgagc  tgccctcac  ccctctgca  aatcccttt  4320
cacctgaga  cctactgaa  tggctggta  aaaaagggg  ctgagtgga  gattatcag  4380
atcacgatt  gcaggattc  cttctgggc  tcattctgg  aacttttgt  agggctgct  4440
ttcttaagt  cccacattt  atggagggt  gaaataatt  gaatgtatt  gatttataa  4500
ttttttttt  tttttgggt  aaaagatgg  tgtagcatt  aaaatggaa  attttctcc  4560
tggtttgct  gtatcttgg  tgtattctc  gtaagtgta  ctcaaatag  tcatcatga  4620
aggttaaaa  agcgaggtg  ccatgttat  ctggtggtt  aggccaggg  ctctccaac  4680
actgtgcca  tgacttgct  tgtgaccct  ggcaagtca  ttaactata  ggtgcctca  4740
ttttccttc  gttaaaatg  ggataataa  actgaccta  ctcaaaggg  agttttgag  4800
catgactaa  gctttttag  aagcatttt  ggatccttc  gcacaggaa  tctcaagac  4860
tgagtattt  ttataatag  aatgtccac  atgaacttg  tacgtccgt  tgtcccaga  4920
gctgtcatt  gtctatatg  ttctccaag  aactgaatg  atccattgg  gaagcggtg  4980
ataactagc  agacaaaat  tgagaatac  taaacaacg  attgccacg  aaacataca  5040
aggatgcct  ttctgtgat  gggtgggat  ttttccctt  ttatgtggg  tatagtagt  5100
acttgtgac  aaaataatt  tggaataat  tctattaat  tcaactctg  agctaattg  5160
actaatctg  gattgtgtt  gttcataat  aaagtgaag  gaatctaaa  aaaaaaaaa  5220
a  5221



<210> 763
<211> 359
<212> PRT
<213> Homo sapiens
<308> O00767
<400> 763

Met Pro Ala His Leu Leu Gln Asp Asp Ile Ser Ser Ser Tyr Thr Thr 
  1               5                  10                  15
Thr Thr Thr Ile Thr Ala Pro Pro Ser Arg Val Leu Gln Asn Gly Gly 
             20                  25                  30
Asp Lys Leu Glu Thr Met Pro Leu Tyr Leu Glu Asp Asp Ile Arg Pro 
         35                  40                  45
Asp Ile Lys Asp Asp Ile Tyr Asp Pro Thr Tyr Lys Asp Lys Glu Gly 
     50                  55                  60
Pro Ser Pro Lys Val Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ser 
 65                  70                  75                  80
Leu Leu His Leu Gly Ala Leu Tyr Gly Ile Thr Leu Ile Pro Thr Cys 
                 85                  90                  95
Lys Phe Tyr Thr Trp Leu Trp Gly Val Phe Tyr Tyr Phe Val Ser Ala 
             100                105                110
Leu Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Ser Tyr 
         115                120                125
Lys Ala Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met 
     130                135                140
Ala Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His 
 145                150                155                160
His Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly 
                 165                170                175
Phe Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala 
             180                185                190
Val Lys Glu Lys Gly Ser Thr Leu Asp Leu Ser Asp Leu Glu Ala Glu 
         195                200                205
Lys Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Met 
     210                215                220
Met Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Phe Trp Gly Glu 
 225                230                235                240
Thr Phe Gln Asn Ser Val Phe Val Ala Thr Phe Leu Arg Tyr Ala Val 
                 245                250                255
Val Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Phe Gly 
             260                265                270
Tyr Arg Pro Tyr Asp Lys Asn Ile Ser Pro Arg Glu Asn Ile Leu Val 
         275                280                285
Ser Leu Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ser Phe 
     290                295                300
Pro Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr 
 305                310                315                320
Thr Phe Phe Ile Asp Cys Met Ala Ala Leu Gly Leu Ala Tyr Asp Arg 
                 325                330                335
Lys Lys Val Ser Lys Ala Ala Ile Leu Ala Arg Ile Lys Arg Thr Gly 
             340                345                350
Asp Gly Asn Tyr Lys Ser Gly 
         355



<210> 764
<211> 639
<212> DNA
<213> Rattus norvegicus
<308> AF036761
<400> 764

cggctgccc  tgaggctct  tctcatcat  gccaacacc  tggcattcc  gaacgatgt  60
tacgaatgg  cccgggatc  ccgcgccca  cacaagttc  cagagacac  cgccgaccc  120
cacaactcc  gccgtggct  tttcttctc  cacgtgggt  ggctgcttg  gcgcaaaca  180
ccggctgtc  aagagaagg  cggaaagct  gacatgtct  acctgaaag  tgagaagct  240
gtgatgttc  agaggaggt  ttacaagcc  ggcctcctg  tcatgtgct  catcctgcc  300
acgctggtg  cctggtact  ctggggtga  acgtttgta  acagcctgt  cgtcagcac  360
ttcttacgg  acgctgtgg  gctcaacgc  acctggctg  tgaacagcg  cgcccacct  420
tatggatat  gcccctacg  caagaacat  agctctcgg  agaacatcc  ggtgtcgat  480
ggagctgtg  gcgagggct  ccacaacta  catcacgcc  tcccctatg  ctactctgc  540
agtgagtac  gctggcaca  caacttcac  acgttcttc  tcgactgca  ggccctcct  600
ggcctggct  atgaccgga  gagggtgtc  aaggccgct  639



<210> 765
<211> 358
<212> PRT
<213> Rattus norvegicus
<308> BAA92436
<400> 765

Met Pro Ala His Ile Leu Gln Glu Ile Ser Gly Ser Tyr Ser Ala Thr 
  1               5                  10                  15
Thr Thr Ile Thr Ala Pro Pro Ser Gly Gly Gln Gln Asn Gly Gly Glu 
             20                  25                  30
Lys Phe Glu Lys Asn Pro His His Trp Gly Ala Asp Val Arg Pro Glu 
         35                  40                  45
Ile Lys Asp Asp Leu Tyr Asp Pro Ser Tyr Gln Asp Glu Glu Gly Pro 
     50                  55                  60
Pro Pro Lys Leu Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ala Leu 
 65                  70                  75                  80
Leu His Ile Gly Ala Leu Tyr Gly Ile Thr Leu Val Pro Ser Cys Lys 
                 85                  90                  95
Val Tyr Thr Cys Leu Phe Ala Tyr Leu Tyr Tyr Val Ile Ser Ala Leu 
             100                105                110
Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Thr Tyr Lys 
         115                120                125
Ala Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met Ala 
     130                135                140
Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His His 
 145                150                155                160
Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly Phe 
                 165                170                175
Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala Val 
             180                185                190
Lys Glu Lys Gly Gly Lys Leu Asp Met Ser Asp Leu Lys Ala Glu Lys 
         195                200                205
Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Leu Met 
     210                215                220
Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Cys Trp Gly Glu Thr 
 225                230                235                240
Phe Val Asn Ser Leu Cys Val Ser Thr Phe Leu Arg Tyr Ala Val Val 
                 245                250                255
Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Tyr Gly Tyr 
             260                265                270
Arg Pro Tyr Asp Lys Asn Ile Ser Ser Arg Glu Asn Ile Leu Val Ser 
         275                280                285
Met Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ala Phe Pro 
     290                295                300
Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr Thr 
 305                310                315                320
Phe Phe Ile Asp Cys Met Ala Leu Leu Gly Leu Ala Tyr Asp Arg Lys 
                 325                330                335
Arg Val Ser Lys Ala Ala Val Leu Ala Arg Ile Lys Arg Thr Gly Glu 
             340                345                350
Glu Ser Cys Lys Ser Gly 
         355



<210> 766
<211> 5221
<212> DNA
<213> Homo sapiens
<308> AF097514
<400> 766

ataaaaggg  gctgaggaa  taccggaca  ggtcacccg  tgccagctc  agcctttaa  60
ttcccggct  ggggacctc  acgcaccgc  gctagcgcc  acaaccagc  agcgtgcaa  120
gcgccgcgg  tcagcgcgt  ccggcgggc  tcgaaaccg  agtcctccg  cgaccccga  180
ctccgctcc  gagcctcag  cccctggaa  gtgatcccg  catccgaga  ccaagatgc  240
ggcccactt  ctgcaggac  atatctcta  ctcctatac  accaccacc  ccattacag  300
gcctccctc  agggtcctg  agaatggag  agataagtt  gagacgatg  ccctctact  360
ggaagacga  attcgccct  atataaaag  tgatatata  gaccccacc  acaaggata  420
ggaaggccc  agccccaag  ttgaatatg  ctggagaaa  atcatcctt  tgtctctgc  480
acacttggg  gccctgtat  ggatcactt  gattcctac  tgcaagttc  acacctggc  540
ttggggggt  ttctactat  ttgtcagtg  cctgggcat  acagcagga  ctcatcgtc  600
gtggagcca  cgctcttac  aagctcggc  gcccctacg  ctctttctg  tcattgcca  660
cacaatggc  ttccagaat  atgtctatg  atgggctcg  gaccaccgt  cccaccaca  720
gttttcaga  acacatgct  atcctcata  ttcccgacg  ggctttttc  tctctcacg  780
gggttggct  cttgtgcgc  aacacccag  tgtcaaaga  aaggggagt  cgctagact  840
gtctgacct  gaagctgag  aactggtga  gttccagag  aggtactac  aacctggct  900
gctgctgat  tgcttcatc  tgcccacgc  tgtgccctg  tatttctgg  gtgaaactt  960
tcaaaacag  gtgttcgtt  ccactttct  gcgatatgc  gtggtgctt  atgccacct  1020
gctggtgaa  agtgctgcc  acctcttcg  atatcgtcc  tatgacaag  acattagcc  1080
ccgggagaa  atcctggtt  cacttggag  tgtgggtga  ggcttccac  actaccacc  1140
ctcctttcc  tatgactac  ctgccagtg  gtaccgctg  cacatcaac  tcaccacat  1200
cttcattga  tgcatggcc  ccctcggtc  ggcctatga  cggaagaaa  tctccaagg  1260
cgccatctt  gccaggatt  aaagaaccg  agatggaaa  tacaagagt  gctgagttt  1320
gggtccctc  ggtttcctt  ttcaaaaac  agccaggca  aggttttaa  gtctgttta  1380
taactactg  ataatgcta  caggatgct  aagatgatg  tgttaaccc  ttccagtac  1440
gtattcttt  aaaattcaa  agtattgaa  gccaacaac  ctgccttta  gatgctaag  1500
tgatattat  tcttctctt  tcctctctc  cttctaggc  cattgtcct  cttttcact  1560
tattgctat  gccctcctt  cccttattg  ctcccaggc  agcagctgg  cagtctttg  1620
tcagtgtcc  gcttccaaa  cctagacaa  ctttctgta  cctaaaacg  atggtcttt  1680
ctccagata  ctctctttc  ttgagctgt  gtgagcttt  aagtaggtg  cttgagcta  1740
agataaaac  gaatcttct  ggtagtccc  tgttgatta  cttcagccc  ggcttttgc  1800
agatggaat  gaaaagcaa  ttcatttga  acaaagctt  taaagcagg  aaattgtcg  1860
gggagagag  tagcatgta  gaatgtaag  atgagggaa  cgaagcaag  ggaacctct  1920
gccatgatc  gacatacag  tgcctacct  atgaggact  caagcccca  cacatagca  1980
gcttccttt  tctcctggc  cggggtaaa  agtggctgc  gtgtttggc  atgctaatt  2040
aatgccgca  catatagtt  aggccgagg  taaagaaaa  acattttaa  tttgtagta  2100
aagtggtct  tgctgggga  gggttttct  ttctttttt  ctttaataa  aaggagatt  2160
cttagttca  atatcaaga  gtcttgaag  tgggtgttt  cagaattgg  aaaaacagc  2220
gctcatgga  ttttgagta  tccatgagc  gctcattac  gttctttcc  ctttctgct  2280
tgccatctt  aggatattg  ttcttcccc  catagtaat  agatggctg  ggcatttcc  2340
aacatccaa  aaaagggaa  gatttaagg  ggtgaagtc  ggtcaaaaa  aaaatatat  2400
tacatatat  cattgctta  aacgttaaa  tattagagt  tttcccttc  aaagaggga  2460
gtttggaaa  aactctgaa  gagaggagg  attagttgg  atgccaatt  cctctccac  2520
gctggacat  agatggaga  gctgaggga  aggatctat  ggcagcttc  aagagcgaa  2580
ttcacatag  aagggatct  agaacacgt  gccaggggc  tgagaaggt  actgagtga  2640
ttattggga  tcttaataa  ataaactag  tattaggtc  attcattaa  tagttccag  2700
ttctccttg  aatgagtaa  aactagaag  cttctctcc  cagtgttgt  ccccttcac  2760
cattttttt  tgaggagaa  ggggtctct  ttaacatct  gcctaaagt  tacaactgc  2820
tggggggca  ggttaggaa  ctcttcact  ccctgattc  tgattcctg  ctctaccct  2880
tctgtccct  ttctttgac  agatctttc  cttccctga  cgttttctt  tttccctgg  2940
caggcagcc  cctttgtgt  tattcagag  cagtgatga  ttgctgtcc  ggcagctcc  3000
tcctgcaca  agaatgctc  gggtcactg  accactgct  ctcttttga  agtagagct  3060
gctgccact  tcacgtggc  tccgcagtg  ctccaccta  acccctgtg  tcccctgcc  3120
cactgatgg  tcaagacaa  gctggcaaa  cctcccaga  acatctctg  cccagaaag  3180
ctctctctc  ctccctctc  catgaggca  agccaagcc  agcgctcat  ttgagccag  3240
gggccagcc  cagagcaaa  gagggttta  tttcagtcc  ctctctctg  gtcagaacc  3300
gagggcatg  tgaatgccc  ctgcttact  ggtgagggt  ccccgcctg  gtcagtgct  3360
tcagctggc  gtgcaatgc  tgtagaagt  ggaggaaac  gttctcact  ggaagaagc  3420
agggcaaga  cccaagtgc  tcacctcga  aggaggccc  gttccctgg  gtcagggtg  3480
actgcaaag  tttggctga  acctgggat  tgagatacc  caaaccctg  tgaacacag  3540
gtctgttca  caaactaac  agcattccc  acagcctag  gcagacaat  gtatagaag  3600
ctggaaaaa  acaaaaaca  aatttgaga  ccttggacc  ctcctgtcc  tgtagctca  3660
tcatcaaag  agaagtctg  ctttgctct  ttaagattg  aaatgtaca  taccaaaca  3720
tcagtccac  gttgagccc  agtgctgga  gggaggaag  cctttcttc  gtgttaatt  3780
cgtagaggc  acaggggtt  gcctggact  aaggcatcc  tgtcttttg  gctattcac  3840
tcagtagaa  aggatctaa  ggaagatca  tgtagttta  ttctgttga  ctgtgcacc  3900
accccttgg  aatgtctgc  ggtatttct  attccacag  tcatcagat  cctgcttga  3960
aatatataa  caataaaaa  aactttcac  tcttcctat  gtaatcgtg  gccatggat  4020
tgatctgta  catgaccct  cataaggct  gatggcacc  caggctgag  gccccaatg  4080
atgtgtggc  gtgggtgtg  gtgggagtg  gtctgctga  taaggaaca  gattttcaa  4140
attctaaag  tcaattcaa  tgacacatt  atgataaac  cagatctga  caagagtcc  4200
gatttctaa  agtccctgc  ttggggggt  tgctgacaa  ttagctcag  tgccttaca  4260
cttttctaa  cacagtgtt  catatgagc  tgccctcac  ccctctgca  aatcccttt  4320
cacctgaga  cctactgaa  tggctggta  aaaaagggg  ctgagtgga  gattatcag  4380
atcacgatt  gcaggattc  cttctgggc  tcattctgg  aacttttgt  agggctgct  4440
ttcttaagt  cccacattt  atggagggt  gaaataatt  gaatgtatt  gatttataa  4500
ttttttttt  tttttgggt  aaaagatgg  tgtagcatt  aaaatggaa  attttctcc  4560
tggtttgct  gtatcttgg  tgtattctc  gtaagtgta  ctcaaatag  tcatcatga  4620
aggttaaaa  agcgaggtg  ccatgttat  ctggtggtt  aggccaggg  ctctccaac  4680
actgtgcca  tgacttgct  tgtgaccct  ggcaagtca  ttaactata  ggtgcctca  4740
ttttccttc  gttaaaatg  ggataataa  actgaccta  ctcaaaggg  agttttgag  4800
catgactaa  gctttttag  aagcatttt  ggatccttc  gcacaggaa  tctcaagac  4860
tgagtattt  ttataatag  aatgtccac  atgaacttg  tacgtccgt  tgtcccaga  4920
gctgtcatt  gtctatatg  ttctccaag  aactgaatg  atccattgg  gaagcggtg  4980
ataactagc  agacaaaat  tgagaatac  taaacaacg  attgccacg  aaacataca  5040
aggatgcct  ttctgtgat  gggtgggat  ttttccctt  ttatgtggg  tatagtagt  5100
acttgtgac  aaaataatt  tggaataat  tctattaat  tcaactctg  agctaattg  5160
actaatctg  gattgtgtt  gttcataat  aaagtgaag  gaatctaaa  aaaaaaaaa  5220
a  5221



<210> 767
<211> 359
<212> PRT
<213> Homo sapiens
<308> O00767
<400> 767

Met Pro Ala His Leu Leu Gln Asp Asp Ile Ser Ser Ser Tyr Thr Thr 
  1               5                  10                  15
Thr Thr Thr Ile Thr Ala Pro Pro Ser Arg Val Leu Gln Asn Gly Gly 
             20                  25                  30
Asp Lys Leu Glu Thr Met Pro Leu Tyr Leu Glu Asp Asp Ile Arg Pro 
         35                  40                  45
Asp Ile Lys Asp Asp Ile Tyr Asp Pro Thr Tyr Lys Asp Lys Glu Gly 
     50                  55                  60
Pro Ser Pro Lys Val Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ser 
 65                  70                  75                  80
Leu Leu His Leu Gly Ala Leu Tyr Gly Ile Thr Leu Ile Pro Thr Cys 
                 85                  90                  95
Lys Phe Tyr Thr Trp Leu Trp Gly Val Phe Tyr Tyr Phe Val Ser Ala 
             100                105                110
Leu Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Ser Tyr 
         115                120                125
Lys Ala Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met 
     130                135                140
Ala Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His 
 145                150                155                160
His Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly 
                 165                170                175
Phe Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala 
             180                185                190
Val Lys Glu Lys Gly Ser Thr Leu Asp Leu Ser Asp Leu Glu Ala Glu 
         195                200                205
Lys Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Met 
     210                215                220
Met Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Phe Trp Gly Glu 
 225                230                235                240
Thr Phe Gln Asn Ser Val Phe Val Ala Thr Phe Leu Arg Tyr Ala Val 
                 245                250                255
Val Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Phe Gly 
             260                265                270
Tyr Arg Pro Tyr Asp Lys Asn Ile Ser Pro Arg Glu Asn Ile Leu Val 
         275                280                285
Ser Leu Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ser Phe 
     290                295                300
Pro Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr 
 305                310                315                320
Thr Phe Phe Ile Asp Cys Met Ala Ala Leu Gly Leu Ala Tyr Asp Arg 
                 325                330                335
Lys Lys Val Ser Lys Ala Ala Ile Leu Ala Arg Ile Lys Arg Thr Gly 
             340                345                350
Asp Gly Asn Tyr Lys Ser Gly 
         355



<210> 768
<211> 639
<212> DNA
<213> Rattus norvegicus
<308> AF036761
<400> 768

cggctgccc  tgaggctct  tctcatcat  gccaacacc  tggcattcc  gaacgatgt  60
tacgaatgg  cccgggatc  ccgcgccca  cacaagttc  cagagacac  cgccgaccc  120
cacaactcc  gccgtggct  tttcttctc  cacgtgggt  ggctgcttg  gcgcaaaca  180
ccggctgtc  aagagaagg  cggaaagct  gacatgtct  acctgaaag  tgagaagct  240
gtgatgttc  agaggaggt  ttacaagcc  ggcctcctg  tcatgtgct  catcctgcc  300
acgctggtg  cctggtact  ctggggtga  acgtttgta  acagcctgt  cgtcagcac  360
ttcttacgg  acgctgtgg  gctcaacgc  acctggctg  tgaacagcg  cgcccacct  420
tatggatat  gcccctacg  caagaacat  agctctcgg  agaacatcc  ggtgtcgat  480
ggagctgtg  gcgagggct  ccacaacta  catcacgcc  tcccctatg  ctactctgc  540
agtgagtac  gctggcaca  caacttcac  acgttcttc  tcgactgca  ggccctcct  600
ggcctggct  atgaccgga  gagggtgtc  aaggccgct  639



<210> 769
<211> 213
<212> PRT
<213> Rattus norvegicus
<308> AAB88865
<400> 769

Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met Ala Phe 
  1               5                  10                  15
Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His His Lys 
             20                  25                  30
Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly Phe Phe 
         35                  40                  45
Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala Val Lys 
     50                  55                  60
Glu Lys Gly Gly Lys Leu Asp Met Ser Asp Leu Lys Ala Glu Lys Leu 
 65                  70                  75                  80
Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Leu Met Cys 
                 85                  90                  95
Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Cys Trp Gly Glu Thr Phe 
             100                105                110
Val Asn Ser Leu Cys Val Ser Thr Phe Leu Arg Tyr Ala Val Val Leu 
         115                120                125
Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Tyr Gly Tyr Arg 
     130                135                140
Pro Tyr Asp Lys Asn Ile Ser Ser Arg Glu Asn Ile Leu Val Ser Met 
 145                150                155                160
Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ala Phe Pro Tyr 
                 165                170                175
Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr Thr Phe 
             180                185                190
Phe Ile Asp Cys Met Ala Leu Leu Gly Leu Ala Tyr Asp Arg Lys Arg 
         195                200                205
Val Ser Lys Ala Ala 
     210



<210> 770
<211> 5221
<212> DNA
<213> Homo sapiens
<308> AF097514
<400> 770

ataaaaggg  gctgaggaa  taccggaca  ggtcacccg  tgccagctc  agcctttaa  60
ttcccggct  ggggacctc  acgcaccgc  gctagcgcc  acaaccagc  agcgtgcaa  120
gcgccgcgg  tcagcgcgt  ccggcgggc  tcgaaaccg  agtcctccg  cgaccccga  180
ctccgctcc  gagcctcag  cccctggaa  gtgatcccg  catccgaga  ccaagatgc  240
ggcccactt  ctgcaggac  atatctcta  ctcctatac  accaccacc  ccattacag  300
gcctccctc  agggtcctg  agaatggag  agataagtt  gagacgatg  ccctctact  360
ggaagacga  attcgccct  atataaaag  tgatatata  gaccccacc  acaaggata  420
ggaaggccc  agccccaag  ttgaatatg  ctggagaaa  atcatcctt  tgtctctgc  480
acacttggg  gccctgtat  ggatcactt  gattcctac  tgcaagttc  acacctggc  540
ttggggggt  ttctactat  ttgtcagtg  cctgggcat  acagcagga  ctcatcgtc  600
gtggagcca  cgctcttac  aagctcggc  gcccctacg  ctctttctg  tcattgcca  660
cacaatggc  ttccagaat  atgtctatg  atgggctcg  gaccaccgt  cccaccaca  720
gttttcaga  acacatgct  atcctcata  ttcccgacg  ggctttttc  tctctcacg  780
gggttggct  cttgtgcgc  aacacccag  tgtcaaaga  aaggggagt  cgctagact  840
gtctgacct  gaagctgag  aactggtga  gttccagag  aggtactac  aacctggct  900
gctgctgat  tgcttcatc  tgcccacgc  tgtgccctg  tatttctgg  gtgaaactt  960
tcaaaacag  gtgttcgtt  ccactttct  gcgatatgc  gtggtgctt  atgccacct  1020
gctggtgaa  agtgctgcc  acctcttcg  atatcgtcc  tatgacaag  acattagcc  1080
ccgggagaa  atcctggtt  cacttggag  tgtgggtga  ggcttccac  actaccacc  1140
ctcctttcc  tatgactac  ctgccagtg  gtaccgctg  cacatcaac  tcaccacat  1200
cttcattga  tgcatggcc  ccctcggtc  ggcctatga  cggaagaaa  tctccaagg  1260
cgccatctt  gccaggatt  aaagaaccg  agatggaaa  tacaagagt  gctgagttt  1320
gggtccctc  ggtttcctt  ttcaaaaac  agccaggca  aggttttaa  gtctgttta  1380
taactactg  ataatgcta  caggatgct  aagatgatg  tgttaaccc  ttccagtac  1440
gtattcttt  aaaattcaa  agtattgaa  gccaacaac  ctgccttta  gatgctaag  1500
tgatattat  tcttctctt  tcctctctc  cttctaggc  cattgtcct  cttttcact  1560
tattgctat  gccctcctt  cccttattg  ctcccaggc  agcagctgg  cagtctttg  1620
tcagtgtcc  gcttccaaa  cctagacaa  ctttctgta  cctaaaacg  atggtcttt  1680
ctccagata  ctctctttc  ttgagctgt  gtgagcttt  aagtaggtg  cttgagcta  1740
agataaaac  gaatcttct  ggtagtccc  tgttgatta  cttcagccc  ggcttttgc  1800
agatggaat  gaaaagcaa  ttcatttga  acaaagctt  taaagcagg  aaattgtcg  1860
gggagagag  tagcatgta  gaatgtaag  atgagggaa  cgaagcaag  ggaacctct  1920
gccatgatc  gacatacag  tgcctacct  atgaggact  caagcccca  cacatagca  1980
gcttccttt  tctcctggc  cggggtaaa  agtggctgc  gtgtttggc  atgctaatt  2040
aatgccgca  catatagtt  aggccgagg  taaagaaaa  acattttaa  tttgtagta  2100
aagtggtct  tgctgggga  gggttttct  ttctttttt  ctttaataa  aaggagatt  2160
cttagttca  atatcaaga  gtcttgaag  tgggtgttt  cagaattgg  aaaaacagc  2220
gctcatgga  ttttgagta  tccatgagc  gctcattac  gttctttcc  ctttctgct  2280
tgccatctt  aggatattg  ttcttcccc  catagtaat  agatggctg  ggcatttcc  2340
aacatccaa  aaaagggaa  gatttaagg  ggtgaagtc  ggtcaaaaa  aaaatatat  2400
tacatatat  cattgctta  aacgttaaa  tattagagt  tttcccttc  aaagaggga  2460
gtttggaaa  aactctgaa  gagaggagg  attagttgg  atgccaatt  cctctccac  2520
gctggacat  agatggaga  gctgaggga  aggatctat  ggcagcttc  aagagcgaa  2580
ttcacatag  aagggatct  agaacacgt  gccaggggc  tgagaaggt  actgagtga  2640
ttattggga  tcttaataa  ataaactag  tattaggtc  attcattaa  tagttccag  2700
ttctccttg  aatgagtaa  aactagaag  cttctctcc  cagtgttgt  ccccttcac  2760
cattttttt  tgaggagaa  ggggtctct  ttaacatct  gcctaaagt  tacaactgc  2820
tggggggca  ggttaggaa  ctcttcact  ccctgattc  tgattcctg  ctctaccct  2880
tctgtccct  ttctttgac  agatctttc  cttccctga  cgttttctt  tttccctgg  2940
caggcagcc  cctttgtgt  tattcagag  cagtgatga  ttgctgtcc  ggcagctcc  3000
tcctgcaca  agaatgctc  gggtcactg  accactgct  ctcttttga  agtagagct  3060
gctgccact  tcacgtggc  tccgcagtg  ctccaccta  acccctgtg  tcccctgcc  3120
cactgatgg  tcaagacaa  gctggcaaa  cctcccaga  acatctctg  cccagaaag  3180
ctctctctc  ctccctctc  catgaggca  agccaagcc  agcgctcat  ttgagccag  3240
gggccagcc  cagagcaaa  gagggttta  tttcagtcc  ctctctctg  gtcagaacc  3300
gagggcatg  tgaatgccc  ctgcttact  ggtgagggt  ccccgcctg  gtcagtgct  3360
tcagctggc  gtgcaatgc  tgtagaagt  ggaggaaac  gttctcact  ggaagaagc  3420
agggcaaga  cccaagtgc  tcacctcga  aggaggccc  gttccctgg  gtcagggtg  3480
actgcaaag  tttggctga  acctgggat  tgagatacc  caaaccctg  tgaacacag  3540
gtctgttca  caaactaac  agcattccc  acagcctag  gcagacaat  gtatagaag  3600
ctggaaaaa  acaaaaaca  aatttgaga  ccttggacc  ctcctgtcc  tgtagctca  3660
tcatcaaag  agaagtctg  ctttgctct  ttaagattg  aaatgtaca  taccaaaca  3720
tcagtccac  gttgagccc  agtgctgga  gggaggaag  cctttcttc  gtgttaatt  3780
cgtagaggc  acaggggtt  gcctggact  aaggcatcc  tgtcttttg  gctattcac  3840
tcagtagaa  aggatctaa  ggaagatca  tgtagttta  ttctgttga  ctgtgcacc  3900
accccttgg  aatgtctgc  ggtatttct  attccacag  tcatcagat  cctgcttga  3960
aatatataa  caataaaaa  aactttcac  tcttcctat  gtaatcgtg  gccatggat  4020
tgatctgta  catgaccct  cataaggct  gatggcacc  caggctgag  gccccaatg  4080
atgtgtggc  gtgggtgtg  gtgggagtg  gtctgctga  taaggaaca  gattttcaa  4140
attctaaag  tcaattcaa  tgacacatt  atgataaac  cagatctga  caagagtcc  4200
gatttctaa  agtccctgc  ttggggggt  tgctgacaa  ttagctcag  tgccttaca  4260
cttttctaa  cacagtgtt  catatgagc  tgccctcac  ccctctgca  aatcccttt  4320
cacctgaga  cctactgaa  tggctggta  aaaaagggg  ctgagtgga  gattatcag  4380
atcacgatt  gcaggattc  cttctgggc  tcattctgg  aacttttgt  agggctgct  4440
ttcttaagt  cccacattt  atggagggt  gaaataatt  gaatgtatt  gatttataa  4500
ttttttttt  tttttgggt  aaaagatgg  tgtagcatt  aaaatggaa  attttctcc  4560
tggtttgct  gtatcttgg  tgtattctc  gtaagtgta  ctcaaatag  tcatcatga  4620
aggttaaaa  agcgaggtg  ccatgttat  ctggtggtt  aggccaggg  ctctccaac  4680
actgtgcca  tgacttgct  tgtgaccct  ggcaagtca  ttaactata  ggtgcctca  4740
ttttccttc  gttaaaatg  ggataataa  actgaccta  ctcaaaggg  agttttgag  4800
catgactaa  gctttttag  aagcatttt  ggatccttc  gcacaggaa  tctcaagac  4860
tgagtattt  ttataatag  aatgtccac  atgaacttg  tacgtccgt  tgtcccaga  4920
gctgtcatt  gtctatatg  ttctccaag  aactgaatg  atccattgg  gaagcggtg  4980
ataactagc  agacaaaat  tgagaatac  taaacaacg  attgccacg  aaacataca  5040
aggatgcct  ttctgtgat  gggtgggat  ttttccctt  ttatgtggg  tatagtagt  5100
acttgtgac  aaaataatt  tggaataat  tctattaat  tcaactctg  agctaattg  5160
actaatctg  gattgtgtt  gttcataat  aaagtgaag  gaatctaaa  aaaaaaaaa  5220
a  5221



<210> 771
<211> 359
<212> PRT
<213> Homo sapiens
<308> O00767
<400> 771

Met Pro Ala His Leu Leu Gln Asp Asp Ile Ser Ser Ser Tyr Thr Thr 
  1               5                  10                  15
Thr Thr Thr Ile Thr Ala Pro Pro Ser Arg Val Leu Gln Asn Gly Gly 
             20                  25                  30
Asp Lys Leu Glu Thr Met Pro Leu Tyr Leu Glu Asp Asp Ile Arg Pro 
         35                  40                  45
Asp Ile Lys Asp Asp Ile Tyr Asp Pro Thr Tyr Lys Asp Lys Glu Gly 
     50                  55                  60
Pro Ser Pro Lys Val Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ser 
 65                  70                  75                  80
Leu Leu His Leu Gly Ala Leu Tyr Gly Ile Thr Leu Ile Pro Thr Cys 
                 85                  90                  95
Lys Phe Tyr Thr Trp Leu Trp Gly Val Phe Tyr Tyr Phe Val Ser Ala 
             100                105                110
Leu Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Ser Tyr 
         115                120                125
Lys Ala Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met 
     130                135                140
Ala Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His 
 145                150                155                160
His Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly 
                 165                170                175
Phe Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala 
             180                185                190
Val Lys Glu Lys Gly Ser Thr Leu Asp Leu Ser Asp Leu Glu Ala Glu 
         195                200                205
Lys Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Met 
     210                215                220
Met Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Phe Trp Gly Glu 
 225                230                235                240
Thr Phe Gln Asn Ser Val Phe Val Ala Thr Phe Leu Arg Tyr Ala Val 
                 245                250                255
Val Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Phe Gly 
             260                265                270
Tyr Arg Pro Tyr Asp Lys Asn Ile Ser Pro Arg Glu Asn Ile Leu Val 
         275                280                285
Ser Leu Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ser Phe 
     290                295                300
Pro Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr 
 305                310                315                320
Thr Phe Phe Ile Asp Cys Met Ala Ala Leu Gly Leu Ala Tyr Asp Arg 
                 325                330                335
Lys Lys Val Ser Lys Ala Ala Ile Leu Ala Arg Ile Lys Arg Thr Gly 
             340                345                350
Asp Gly Asn Tyr Lys Ser Gly 
         355



<210> 772
<211> 639
<212> DNA
<213> Rattus norvegicus
<308> AF036761
<400> 772

cggctgccc  tgaggctct  tctcatcat  gccaacacc  tggcattcc  gaacgatgt  60
tacgaatgg  cccgggatc  ccgcgccca  cacaagttc  cagagacac  cgccgaccc  120
cacaactcc  gccgtggct  tttcttctc  cacgtgggt  ggctgcttg  gcgcaaaca  180
ccggctgtc  aagagaagg  cggaaagct  gacatgtct  acctgaaag  tgagaagct  240
gtgatgttc  agaggaggt  ttacaagcc  ggcctcctg  tcatgtgct  catcctgcc  300
acgctggtg  cctggtact  ctggggtga  acgtttgta  acagcctgt  cgtcagcac  360
ttcttacgg  acgctgtgg  gctcaacgc  acctggctg  tgaacagcg  cgcccacct  420
tatggatat  gcccctacg  caagaacat  agctctcgg  agaacatcc  ggtgtcgat  480
ggagctgtg  gcgagggct  ccacaacta  catcacgcc  tcccctatg  ctactctgc  540
agtgagtac  gctggcaca  caacttcac  acgttcttc  tcgactgca  ggccctcct  600
ggcctggct  atgaccgga  gagggtgtc  aaggccgct  639



<210> 773
<211> 213
<212> PRT
<213> Rattus norvegicus
<308> AAB88865
<400> 773

Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met Ala Phe 
  1               5                  10                  15
Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His His Lys 
             20                  25                  30
Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly Phe Phe 
         35                  40                  45
Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala Val Lys 
     50                  55                  60
Glu Lys Gly Gly Lys Leu Asp Met Ser Asp Leu Lys Ala Glu Lys Leu 
 65                  70                  75                  80
Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Leu Met Cys 
                 85                  90                  95
Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Cys Trp Gly Glu Thr Phe 
             100                105                110
Val Asn Ser Leu Cys Val Ser Thr Phe Leu Arg Tyr Ala Val Val Leu 
         115                120                125
Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Tyr Gly Tyr Arg 
     130                135                140
Pro Tyr Asp Lys Asn Ile Ser Ser Arg Glu Asn Ile Leu Val Ser Met 
 145                150                155                160
Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ala Phe Pro Tyr 
                 165                170                175
Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr Thr Phe 
             180                185                190
Phe Ile Asp Cys Met Ala Leu Leu Gly Leu Ala Tyr Asp Arg Lys Arg 
         195                200                205
Val Ser Lys Ala Ala 
     210



<210> 774
<211> 5221
<212> DNA
<213> Homo sapiens
<308> AF097514
<400> 774

ataaaaggg  gctgaggaa  taccggaca  ggtcacccg  tgccagctc  agcctttaa  60
ttcccggct  ggggacctc  acgcaccgc  gctagcgcc  acaaccagc  agcgtgcaa  120
gcgccgcgg  tcagcgcgt  ccggcgggc  tcgaaaccg  agtcctccg  cgaccccga  180
ctccgctcc  gagcctcag  cccctggaa  gtgatcccg  catccgaga  ccaagatgc  240
ggcccactt  ctgcaggac  atatctcta  ctcctatac  accaccacc  ccattacag  300
gcctccctc  agggtcctg  agaatggag  agataagtt  gagacgatg  ccctctact  360
ggaagacga  attcgccct  atataaaag  tgatatata  gaccccacc  acaaggata  420
ggaaggccc  agccccaag  ttgaatatg  ctggagaaa  atcatcctt  tgtctctgc  480
acacttggg  gccctgtat  ggatcactt  gattcctac  tgcaagttc  acacctggc  540
ttggggggt  ttctactat  ttgtcagtg  cctgggcat  acagcagga  ctcatcgtc  600
gtggagcca  cgctcttac  aagctcggc  gcccctacg  ctctttctg  tcattgcca  660
cacaatggc  ttccagaat  atgtctatg  atgggctcg  gaccaccgt  cccaccaca  720
gttttcaga  acacatgct  atcctcata  ttcccgacg  ggctttttc  tctctcacg  780
gggttggct  cttgtgcgc  aacacccag  tgtcaaaga  aaggggagt  cgctagact  840
gtctgacct  gaagctgag  aactggtga  gttccagag  aggtactac  aacctggct  900
gctgctgat  tgcttcatc  tgcccacgc  tgtgccctg  tatttctgg  gtgaaactt  960
tcaaaacag  gtgttcgtt  ccactttct  gcgatatgc  gtggtgctt  atgccacct  1020
gctggtgaa  agtgctgcc  acctcttcg  atatcgtcc  tatgacaag  acattagcc  1080
ccgggagaa  atcctggtt  cacttggag  tgtgggtga  ggcttccac  actaccacc  1140
ctcctttcc  tatgactac  ctgccagtg  gtaccgctg  cacatcaac  tcaccacat  1200
cttcattga  tgcatggcc  ccctcggtc  ggcctatga  cggaagaaa  tctccaagg  1260
cgccatctt  gccaggatt  aaagaaccg  agatggaaa  tacaagagt  gctgagttt  1320
gggtccctc  ggtttcctt  ttcaaaaac  agccaggca  aggttttaa  gtctgttta  1380
taactactg  ataatgcta  caggatgct  aagatgatg  tgttaaccc  ttccagtac  1440
gtattcttt  aaaattcaa  agtattgaa  gccaacaac  ctgccttta  gatgctaag  1500
tgatattat  tcttctctt  tcctctctc  cttctaggc  cattgtcct  cttttcact  1560
tattgctat  gccctcctt  cccttattg  ctcccaggc  agcagctgg  cagtctttg  1620
tcagtgtcc  gcttccaaa  cctagacaa  ctttctgta  cctaaaacg  atggtcttt  1680
ctccagata  ctctctttc  ttgagctgt  gtgagcttt  aagtaggtg  cttgagcta  1740
agataaaac  gaatcttct  ggtagtccc  tgttgatta  cttcagccc  ggcttttgc  1800
agatggaat  gaaaagcaa  ttcatttga  acaaagctt  taaagcagg  aaattgtcg  1860
gggagagag  tagcatgta  gaatgtaag  atgagggaa  cgaagcaag  ggaacctct  1920
gccatgatc  gacatacag  tgcctacct  atgaggact  caagcccca  cacatagca  1980
gcttccttt  tctcctggc  cggggtaaa  agtggctgc  gtgtttggc  atgctaatt  2040
aatgccgca  catatagtt  aggccgagg  taaagaaaa  acattttaa  tttgtagta  2100
aagtggtct  tgctgggga  gggttttct  ttctttttt  ctttaataa  aaggagatt  2160
cttagttca  atatcaaga  gtcttgaag  tgggtgttt  cagaattgg  aaaaacagc  2220
gctcatgga  ttttgagta  tccatgagc  gctcattac  gttctttcc  ctttctgct  2280
tgccatctt  aggatattg  ttcttcccc  catagtaat  agatggctg  ggcatttcc  2340
aacatccaa  aaaagggaa  gatttaagg  ggtgaagtc  ggtcaaaaa  aaaatatat  2400
tacatatat  cattgctta  aacgttaaa  tattagagt  tttcccttc  aaagaggga  2460
gtttggaaa  aactctgaa  gagaggagg  attagttgg  atgccaatt  cctctccac  2520
gctggacat  agatggaga  gctgaggga  aggatctat  ggcagcttc  aagagcgaa  2580
ttcacatag  aagggatct  agaacacgt  gccaggggc  tgagaaggt  actgagtga  2640
ttattggga  tcttaataa  ataaactag  tattaggtc  attcattaa  tagttccag  2700
ttctccttg  aatgagtaa  aactagaag  cttctctcc  cagtgttgt  ccccttcac  2760
cattttttt  tgaggagaa  ggggtctct  ttaacatct  gcctaaagt  tacaactgc  2820
tggggggca  ggttaggaa  ctcttcact  ccctgattc  tgattcctg  ctctaccct  2880
tctgtccct  ttctttgac  agatctttc  cttccctga  cgttttctt  tttccctgg  2940
caggcagcc  cctttgtgt  tattcagag  cagtgatga  ttgctgtcc  ggcagctcc  3000
tcctgcaca  agaatgctc  gggtcactg  accactgct  ctcttttga  agtagagct  3060
gctgccact  tcacgtggc  tccgcagtg  ctccaccta  acccctgtg  tcccctgcc  3120
cactgatgg  tcaagacaa  gctggcaaa  cctcccaga  acatctctg  cccagaaag  3180
ctctctctc  ctccctctc  catgaggca  agccaagcc  agcgctcat  ttgagccag  3240
gggccagcc  cagagcaaa  gagggttta  tttcagtcc  ctctctctg  gtcagaacc  3300
gagggcatg  tgaatgccc  ctgcttact  ggtgagggt  ccccgcctg  gtcagtgct  3360
tcagctggc  gtgcaatgc  tgtagaagt  ggaggaaac  gttctcact  ggaagaagc  3420
agggcaaga  cccaagtgc  tcacctcga  aggaggccc  gttccctgg  gtcagggtg  3480
actgcaaag  tttggctga  acctgggat  tgagatacc  caaaccctg  tgaacacag  3540
gtctgttca  caaactaac  agcattccc  acagcctag  gcagacaat  gtatagaag  3600
ctggaaaaa  acaaaaaca  aatttgaga  ccttggacc  ctcctgtcc  tgtagctca  3660
tcatcaaag  agaagtctg  ctttgctct  ttaagattg  aaatgtaca  taccaaaca  3720
tcagtccac  gttgagccc  agtgctgga  gggaggaag  cctttcttc  gtgttaatt  3780
cgtagaggc  acaggggtt  gcctggact  aaggcatcc  tgtcttttg  gctattcac  3840
tcagtagaa  aggatctaa  ggaagatca  tgtagttta  ttctgttga  ctgtgcacc  3900
accccttgg  aatgtctgc  ggtatttct  attccacag  tcatcagat  cctgcttga  3960
aatatataa  caataaaaa  aactttcac  tcttcctat  gtaatcgtg  gccatggat  4020
tgatctgta  catgaccct  cataaggct  gatggcacc  caggctgag  gccccaatg  4080
atgtgtggc  gtgggtgtg  gtgggagtg  gtctgctga  taaggaaca  gattttcaa  4140
attctaaag  tcaattcaa  tgacacatt  atgataaac  cagatctga  caagagtcc  4200
gatttctaa  agtccctgc  ttggggggt  tgctgacaa  ttagctcag  tgccttaca  4260
cttttctaa  cacagtgtt  catatgagc  tgccctcac  ccctctgca  aatcccttt  4320
cacctgaga  cctactgaa  tggctggta  aaaaagggg  ctgagtgga  gattatcag  4380
atcacgatt  gcaggattc  cttctgggc  tcattctgg  aacttttgt  agggctgct  4440
ttcttaagt  cccacattt  atggagggt  gaaataatt  gaatgtatt  gatttataa  4500
ttttttttt  tttttgggt  aaaagatgg  tgtagcatt  aaaatggaa  attttctcc  4560
tggtttgct  gtatcttgg  tgtattctc  gtaagtgta  ctcaaatag  tcatcatga  4620
aggttaaaa  agcgaggtg  ccatgttat  ctggtggtt  aggccaggg  ctctccaac  4680
actgtgcca  tgacttgct  tgtgaccct  ggcaagtca  ttaactata  ggtgcctca  4740
ttttccttc  gttaaaatg  ggataataa  actgaccta  ctcaaaggg  agttttgag  4800
catgactaa  gctttttag  aagcatttt  ggatccttc  gcacaggaa  tctcaagac  4860
tgagtattt  ttataatag  aatgtccac  atgaacttg  tacgtccgt  tgtcccaga  4920
gctgtcatt  gtctatatg  ttctccaag  aactgaatg  atccattgg  gaagcggtg  4980
ataactagc  agacaaaat  tgagaatac  taaacaacg  attgccacg  aaacataca  5040
aggatgcct  ttctgtgat  gggtgggat  ttttccctt  ttatgtggg  tatagtagt  5100
acttgtgac  aaaataatt  tggaataat  tctattaat  tcaactctg  agctaattg  5160
actaatctg  gattgtgtt  gttcataat  aaagtgaag  gaatctaaa  aaaaaaaaa  5220
a  5221



<210> 775
<211> 359
<212> PRT
<213> Homo sapiens
<308> O00767
<400> 775

Met Pro Ala His Leu Leu Gln Asp Asp Ile Ser Ser Ser Tyr Thr Thr 
  1               5                  10                  15
Thr Thr Thr Ile Thr Ala Pro Pro Ser Arg Val Leu Gln Asn Gly Gly 
             20                  25                  30
Asp Lys Leu Glu Thr Met Pro Leu Tyr Leu Glu Asp Asp Ile Arg Pro 
         35                  40                  45
Asp Ile Lys Asp Asp Ile Tyr Asp Pro Thr Tyr Lys Asp Lys Glu Gly 
     50                  55                  60
Pro Ser Pro Lys Val Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ser 
 65                  70                  75                  80
Leu Leu His Leu Gly Ala Leu Tyr Gly Ile Thr Leu Ile Pro Thr Cys 
                 85                  90                  95
Lys Phe Tyr Thr Trp Leu Trp Gly Val Phe Tyr Tyr Phe Val Ser Ala 
             100                105                110
Leu Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Ser Tyr 
         115                120                125
Lys Ala Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met 
     130                135                140
Ala Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His 
 145                150                155                160
His Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly 
                 165                170                175
Phe Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala 
             180                185                190
Val Lys Glu Lys Gly Ser Thr Leu Asp Leu Ser Asp Leu Glu Ala Glu 
         195                200                205
Lys Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Met 
     210                215                220
Met Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Phe Trp Gly Glu 
 225                230                235                240
Thr Phe Gln Asn Ser Val Phe Val Ala Thr Phe Leu Arg Tyr Ala Val 
                 245                250                255
Val Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Phe Gly 
             260                265                270
Tyr Arg Pro Tyr Asp Lys Asn Ile Ser Pro Arg Glu Asn Ile Leu Val 
         275                280                285
Ser Leu Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ser Phe 
     290                295                300
Pro Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr 
 305                310                315                320
Thr Phe Phe Ile Asp Cys Met Ala Ala Leu Gly Leu Ala Tyr Asp Arg 
                 325                330                335
Lys Lys Val Ser Lys Ala Ala Ile Leu Ala Arg Ile Lys Arg Thr Gly 
             340                345                350
Asp Gly Asn Tyr Lys Ser Gly 
         355



<210> 776
<211> 639
<212> DNA
<213> Rattus norvegicus
<308> AF036761
<400> 776

cggctgccc  tgaggctct  tctcatcat  gccaacacc  tggcattcc  gaacgatgt  60
tacgaatgg  cccgggatc  ccgcgccca  cacaagttc  cagagacac  cgccgaccc  120
cacaactcc  gccgtggct  tttcttctc  cacgtgggt  ggctgcttg  gcgcaaaca  180
ccggctgtc  aagagaagg  cggaaagct  gacatgtct  acctgaaag  tgagaagct  240
gtgatgttc  agaggaggt  ttacaagcc  ggcctcctg  tcatgtgct  catcctgcc  300
acgctggtg  cctggtact  ctggggtga  acgtttgta  acagcctgt  cgtcagcac  360
ttcttacgg  acgctgtgg  gctcaacgc  acctggctg  tgaacagcg  cgcccacct  420
tatggatat  gcccctacg  caagaacat  agctctcgg  agaacatcc  ggtgtcgat  480
ggagctgtg  gcgagggct  ccacaacta  catcacgcc  tcccctatg  ctactctgc  540
agtgagtac  gctggcaca  caacttcac  acgttcttc  tcgactgca  ggccctcct  600
ggcctggct  atgaccgga  gagggtgtc  aaggccgct  639



<210> 777
<211> 358
<212> PRT
<213> Rattus norvegicus
<308> BAA92436
<400> 777

Met Pro Ala His Ile Leu Gln Glu Ile Ser Gly Ser Tyr Ser Ala Thr 
  1               5                  10                  15
Thr Thr Ile Thr Ala Pro Pro Ser Gly Gly Gln Gln Asn Gly Gly Glu 
             20                  25                  30
Lys Phe Glu Lys Asn Pro His His Trp Gly Ala Asp Val Arg Pro Glu 
         35                  40                  45
Ile Lys Asp Asp Leu Tyr Asp Pro Ser Tyr Gln Asp Glu Glu Gly Pro 
     50                  55                  60
Pro Pro Lys Leu Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ala Leu 
 65                  70                  75                  80
Leu His Ile Gly Ala Leu Tyr Gly Ile Thr Leu Val Pro Ser Cys Lys 
                 85                  90                  95
Val Tyr Thr Cys Leu Phe Ala Tyr Leu Tyr Tyr Val Ile Ser Ala Leu 
             100                105                110
Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Thr Tyr Lys 
         115                120                125
Ala Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met Ala 
     130                135                140
Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His His 
 145                150                155                160
Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly Phe 
                 165                170                175
Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala Val 
             180                185                190
Lys Glu Lys Gly Gly Lys Leu Asp Met Ser Asp Leu Lys Ala Glu Lys 
         195                200                205
Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Leu Met 
     210                215                220
Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Cys Trp Gly Glu Thr 
 225                230                235                240
Phe Val Asn Ser Leu Cys Val Ser Thr Phe Leu Arg Tyr Ala Val Val 
                 245                250                255
Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Tyr Gly Tyr 
             260                265                270
Arg Pro Tyr Asp Lys Asn Ile Ser Ser Arg Glu Asn Ile Leu Val Ser 
         275                280                285
Met Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ala Phe Pro 
     290                295                300
Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr Thr 
 305                310                315                320
Phe Phe Ile Asp Cys Met Ala Leu Leu Gly Leu Ala Tyr Asp Arg Lys 
                 325                330                335
Arg Val Ser Lys Ala Ala Val Leu Ala Arg Ile Lys Arg Thr Gly Glu 
             340                345                350
Glu Ser Cys Lys Ser Gly 
         355



<210> 778
<211> 5221
<212> DNA
<213> Homo sapiens
<308> AF097514
<400> 778

ataaaaggg  gctgaggaa  taccggaca  ggtcacccg  tgccagctc  agcctttaa  60
ttcccggct  ggggacctc  acgcaccgc  gctagcgcc  acaaccagc  agcgtgcaa  120
gcgccgcgg  tcagcgcgt  ccggcgggc  tcgaaaccg  agtcctccg  cgaccccga  180
ctccgctcc  gagcctcag  cccctggaa  gtgatcccg  catccgaga  ccaagatgc  240
ggcccactt  ctgcaggac  atatctcta  ctcctatac  accaccacc  ccattacag  300
gcctccctc  agggtcctg  agaatggag  agataagtt  gagacgatg  ccctctact  360
ggaagacga  attcgccct  atataaaag  tgatatata  gaccccacc  acaaggata  420
ggaaggccc  agccccaag  ttgaatatg  ctggagaaa  atcatcctt  tgtctctgc  480
acacttggg  gccctgtat  ggatcactt  gattcctac  tgcaagttc  acacctggc  540
ttggggggt  ttctactat  ttgtcagtg  cctgggcat  acagcagga  ctcatcgtc  600
gtggagcca  cgctcttac  aagctcggc  gcccctacg  ctctttctg  tcattgcca  660
cacaatggc  ttccagaat  atgtctatg  atgggctcg  gaccaccgt  cccaccaca  720
gttttcaga  acacatgct  atcctcata  ttcccgacg  ggctttttc  tctctcacg  780
gggttggct  cttgtgcgc  aacacccag  tgtcaaaga  aaggggagt  cgctagact  840
gtctgacct  gaagctgag  aactggtga  gttccagag  aggtactac  aacctggct  900
gctgctgat  tgcttcatc  tgcccacgc  tgtgccctg  tatttctgg  gtgaaactt  960
tcaaaacag  gtgttcgtt  ccactttct  gcgatatgc  gtggtgctt  atgccacct  1020
gctggtgaa  agtgctgcc  acctcttcg  atatcgtcc  tatgacaag  acattagcc  1080
ccgggagaa  atcctggtt  cacttggag  tgtgggtga  ggcttccac  actaccacc  1140
ctcctttcc  tatgactac  ctgccagtg  gtaccgctg  cacatcaac  tcaccacat  1200
cttcattga  tgcatggcc  ccctcggtc  ggcctatga  cggaagaaa  tctccaagg  1260
cgccatctt  gccaggatt  aaagaaccg  agatggaaa  tacaagagt  gctgagttt  1320
gggtccctc  ggtttcctt  ttcaaaaac  agccaggca  aggttttaa  gtctgttta  1380
taactactg  ataatgcta  caggatgct  aagatgatg  tgttaaccc  ttccagtac  1440
gtattcttt  aaaattcaa  agtattgaa  gccaacaac  ctgccttta  gatgctaag  1500
tgatattat  tcttctctt  tcctctctc  cttctaggc  cattgtcct  cttttcact  1560
tattgctat  gccctcctt  cccttattg  ctcccaggc  agcagctgg  cagtctttg  1620
tcagtgtcc  gcttccaaa  cctagacaa  ctttctgta  cctaaaacg  atggtcttt  1680
ctccagata  ctctctttc  ttgagctgt  gtgagcttt  aagtaggtg  cttgagcta  1740
agataaaac  gaatcttct  ggtagtccc  tgttgatta  cttcagccc  ggcttttgc  1800
agatggaat  gaaaagcaa  ttcatttga  acaaagctt  taaagcagg  aaattgtcg  1860
gggagagag  tagcatgta  gaatgtaag  atgagggaa  cgaagcaag  ggaacctct  1920
gccatgatc  gacatacag  tgcctacct  atgaggact  caagcccca  cacatagca  1980
gcttccttt  tctcctggc  cggggtaaa  agtggctgc  gtgtttggc  atgctaatt  2040
aatgccgca  catatagtt  aggccgagg  taaagaaaa  acattttaa  tttgtagta  2100
aagtggtct  tgctgggga  gggttttct  ttctttttt  ctttaataa  aaggagatt  2160
cttagttca  atatcaaga  gtcttgaag  tgggtgttt  cagaattgg  aaaaacagc  2220
gctcatgga  ttttgagta  tccatgagc  gctcattac  gttctttcc  ctttctgct  2280
tgccatctt  aggatattg  ttcttcccc  catagtaat  agatggctg  ggcatttcc  2340
aacatccaa  aaaagggaa  gatttaagg  ggtgaagtc  ggtcaaaaa  aaaatatat  2400
tacatatat  cattgctta  aacgttaaa  tattagagt  tttcccttc  aaagaggga  2460
gtttggaaa  aactctgaa  gagaggagg  attagttgg  atgccaatt  cctctccac  2520
gctggacat  agatggaga  gctgaggga  aggatctat  ggcagcttc  aagagcgaa  2580
ttcacatag  aagggatct  agaacacgt  gccaggggc  tgagaaggt  actgagtga  2640
ttattggga  tcttaataa  ataaactag  tattaggtc  attcattaa  tagttccag  2700
ttctccttg  aatgagtaa  aactagaag  cttctctcc  cagtgttgt  ccccttcac  2760
cattttttt  tgaggagaa  ggggtctct  ttaacatct  gcctaaagt  tacaactgc  2820
tggggggca  ggttaggaa  ctcttcact  ccctgattc  tgattcctg  ctctaccct  2880
tctgtccct  ttctttgac  agatctttc  cttccctga  cgttttctt  tttccctgg  2940
caggcagcc  cctttgtgt  tattcagag  cagtgatga  ttgctgtcc  ggcagctcc  3000
tcctgcaca  agaatgctc  gggtcactg  accactgct  ctcttttga  agtagagct  3060
gctgccact  tcacgtggc  tccgcagtg  ctccaccta  acccctgtg  tcccctgcc  3120
cactgatgg  tcaagacaa  gctggcaaa  cctcccaga  acatctctg  cccagaaag  3180
ctctctctc  ctccctctc  catgaggca  agccaagcc  agcgctcat  ttgagccag  3240
gggccagcc  cagagcaaa  gagggttta  tttcagtcc  ctctctctg  gtcagaacc  3300
gagggcatg  tgaatgccc  ctgcttact  ggtgagggt  ccccgcctg  gtcagtgct  3360
tcagctggc  gtgcaatgc  tgtagaagt  ggaggaaac  gttctcact  ggaagaagc  3420
agggcaaga  cccaagtgc  tcacctcga  aggaggccc  gttccctgg  gtcagggtg  3480
actgcaaag  tttggctga  acctgggat  tgagatacc  caaaccctg  tgaacacag  3540
gtctgttca  caaactaac  agcattccc  acagcctag  gcagacaat  gtatagaag  3600
ctggaaaaa  acaaaaaca  aatttgaga  ccttggacc  ctcctgtcc  tgtagctca  3660
tcatcaaag  agaagtctg  ctttgctct  ttaagattg  aaatgtaca  taccaaaca  3720
tcagtccac  gttgagccc  agtgctgga  gggaggaag  cctttcttc  gtgttaatt  3780
cgtagaggc  acaggggtt  gcctggact  aaggcatcc  tgtcttttg  gctattcac  3840
tcagtagaa  aggatctaa  ggaagatca  tgtagttta  ttctgttga  ctgtgcacc  3900
accccttgg  aatgtctgc  ggtatttct  attccacag  tcatcagat  cctgcttga  3960
aatatataa  caataaaaa  aactttcac  tcttcctat  gtaatcgtg  gccatggat  4020
tgatctgta  catgaccct  cataaggct  gatggcacc  caggctgag  gccccaatg  4080
atgtgtggc  gtgggtgtg  gtgggagtg  gtctgctga  taaggaaca  gattttcaa  4140
attctaaag  tcaattcaa  tgacacatt  atgataaac  cagatctga  caagagtcc  4200
gatttctaa  agtccctgc  ttggggggt  tgctgacaa  ttagctcag  tgccttaca  4260
cttttctaa  cacagtgtt  catatgagc  tgccctcac  ccctctgca  aatcccttt  4320
cacctgaga  cctactgaa  tggctggta  aaaaagggg  ctgagtgga  gattatcag  4380
atcacgatt  gcaggattc  cttctgggc  tcattctgg  aacttttgt  agggctgct  4440
ttcttaagt  cccacattt  atggagggt  gaaataatt  gaatgtatt  gatttataa  4500
ttttttttt  tttttgggt  aaaagatgg  tgtagcatt  aaaatggaa  attttctcc  4560
tggtttgct  gtatcttgg  tgtattctc  gtaagtgta  ctcaaatag  tcatcatga  4620
aggttaaaa  agcgaggtg  ccatgttat  ctggtggtt  aggccaggg  ctctccaac  4680
actgtgcca  tgacttgct  tgtgaccct  ggcaagtca  ttaactata  ggtgcctca  4740
ttttccttc  gttaaaatg  ggataataa  actgaccta  ctcaaaggg  agttttgag  4800
catgactaa  gctttttag  aagcatttt  ggatccttc  gcacaggaa  tctcaagac  4860
tgagtattt  ttataatag  aatgtccac  atgaacttg  tacgtccgt  tgtcccaga  4920
gctgtcatt  gtctatatg  ttctccaag  aactgaatg  atccattgg  gaagcggtg  4980
ataactagc  agacaaaat  tgagaatac  taaacaacg  attgccacg  aaacataca  5040
aggatgcct  ttctgtgat  gggtgggat  ttttccctt  ttatgtggg  tatagtagt  5100
acttgtgac  aaaataatt  tggaataat  tctattaat  tcaactctg  agctaattg  5160
actaatctg  gattgtgtt  gttcataat  aaagtgaag  gaatctaaa  aaaaaaaaa  5220
a  5221



<210> 779
<211> 359
<212> PRT
<213> Homo sapiens
<308> O00767
<400> 779

Met Pro Ala His Leu Leu Gln Asp Asp Ile Ser Ser Ser Tyr Thr Thr 
  1               5                  10                  15
Thr Thr Thr Ile Thr Ala Pro Pro Ser Arg Val Leu Gln Asn Gly Gly 
             20                  25                  30
Asp Lys Leu Glu Thr Met Pro Leu Tyr Leu Glu Asp Asp Ile Arg Pro 
         35                  40                  45
Asp Ile Lys Asp Asp Ile Tyr Asp Pro Thr Tyr Lys Asp Lys Glu Gly 
     50                  55                  60
Pro Ser Pro Lys Val Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ser 
 65                  70                  75                  80
Leu Leu His Leu Gly Ala Leu Tyr Gly Ile Thr Leu Ile Pro Thr Cys 
                 85                  90                  95
Lys Phe Tyr Thr Trp Leu Trp Gly Val Phe Tyr Tyr Phe Val Ser Ala 
             100                105                110
Leu Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Ser Tyr 
         115                120                125
Lys Ala Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met 
     130                135                140
Ala Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His 
 145                150                155                160
His Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly 
                 165                170                175
Phe Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala 
             180                185                190
Val Lys Glu Lys Gly Ser Thr Leu Asp Leu Ser Asp Leu Glu Ala Glu 
         195                200                205
Lys Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Met 
     210                215                220
Met Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Phe Trp Gly Glu 
 225                230                235                240
Thr Phe Gln Asn Ser Val Phe Val Ala Thr Phe Leu Arg Tyr Ala Val 
                 245                250                255
Val Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Phe Gly 
             260                265                270
Tyr Arg Pro Tyr Asp Lys Asn Ile Ser Pro Arg Glu Asn Ile Leu Val 
         275                280                285
Ser Leu Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ser Phe 
     290                295                300
Pro Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr 
 305                310                315                320
Thr Phe Phe Ile Asp Cys Met Ala Ala Leu Gly Leu Ala Tyr Asp Arg 
                 325                330                335
Lys Lys Val Ser Lys Ala Ala Ile Leu Ala Arg Ile Lys Arg Thr Gly 
             340                345                350
Asp Gly Asn Tyr Lys Ser Gly 
         355



<210> 780
<211> 1053
<212> DNA
<213> Rattus norvegicus
<308> AF037072
<400> 780

ggagctgtc  agcgctgag  gacaggaaa  gccatggct  aggagtggg  ttacgccag  60
cacaatggt  ctgagcact  gcatgaact  tatccaatt  ccaaagggg  caaccagtc  120
cccattgaa  tgcatacta  agacatcag  catgatcct  ctctgcagc  ttggtcagt  180
tcttatgat  ctggctctg  taagaccat  ctgaacaat  ggaagacct  cagagttgt  240
tttgatgat  ccttcgaca  gtccatgct  agaggtggc  ctctctctg  accctaccg  300
cttcgccaa  tccatcttc  ctggggctc  tcggatgac  atggctctg  gcacacagt  360
gatggagtg  agtatgctg  tgagcttca  ctggttcac  ggaacccga  gtataacac  420
ttcggagag  ctctgaagc  gcccgatgg  attgctgtg  ttggcattt  tctgaagat  480
ggacgggag  aaggcgagt  ccaaattct  cttgatgcc  tggacaaaa  taagactaa  540
ggcaaggag  ctcctttta  tcacttcga  ccatcgtgc  tgttccctg  ttgccggga  600
tattggacc  accatggct  cttcaccac  ccaccctgc  aggagtgca  tgtgtggct  660
ctactgaaa  agcccatga  agtgagctc  gaccagatg  ccaagctgc  cagcctgtt  720
gccagtgca  agaatgagc  cccggtgcc  ctggtgggg  attggcgcc  tcctcagcc  780
atcaagggc  gggtggtga  ggcctcctt  aagtaaggc  ctggacgtg  cctcttcag  840
aaaggaatt  tgtccctga  gagccagct  gcctcctcc  ggtgctccc  gctccaagc  900
atcctacaa  actgagaga  agaagagac  cagtcagat  aaaccgcag  gccttttga  960
atgatctaa  ccagaagca  gaatttcac  cctaacctt  ttaataact  ccttttcta  1020
aaaaattag  atttctagt  taaattcag  gaa  1053



<210> 781
<211> 259
<212> PRT
<213> Rattus norvegicus
<308> P14141
<400> 781

Ala Lys Glu Trp Gly Tyr Ala Ser His Asn Gly Pro Glu His Trp His 
  1               5                  10                  15
Glu Leu Tyr Pro Ile Ala Lys Gly Asp Asn Gln Ser Pro Ile Glu Leu 
             20                  25                  30
His Thr Lys Asp Ile Arg His Asp Pro Ser Leu Gln Pro Trp Ser Val 
         35                  40                  45
Ser Tyr Asp Pro Gly Ser Ala Lys Thr Ile Leu Asn Asn Gly Lys Thr 
     50                  55                  60
Cys Arg Val Val Phe Asp Asp Thr Phe Asp Arg Ser Met Leu Arg Gly 
 65                  70                  75                  80
Gly Pro Leu Ser Gly Pro Tyr Arg Leu Arg Gln Phe His Leu His Trp 
                 85                  90                  95
Gly Ser Ser Asp Asp His Gly Ser Glu His Thr Val Asp Gly Val Lys 
             100                105                110
Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Pro Lys Tyr Asn Thr 
         115                120                125
Phe Gly Glu Ala Leu Lys Gln Pro Asp Gly Ile Ala Val Val Gly Ile 
     130                135                140
Phe Leu Lys Ile Gly Arg Glu Lys Gly Glu Phe Gln Ile Leu Leu Asp 
 145                150                155                160
Ala Leu Asp Lys Ile Lys Thr Lys Gly Lys Glu Ala Pro Phe Asn His 
                 165                170                175
Phe Asp Pro Ser Cys Leu Phe Pro Ala Cys Arg Asp Tyr Trp Thr Tyr 
             180                185                190
His Gly Ser Phe Thr Thr Pro Pro Cys Glu Glu Cys Ile Val Trp Leu 
         195                200                205
Leu Leu Lys Glu Pro Met Thr Val Ser Ser Asp Gln Met Ala Lys Leu 
     210                215                220
Arg Ser Leu Phe Ala Ser Ala Glu Asn Glu Pro Pro Val Pro Leu Val 
 225                230                235                240
Gly Asn Trp Arg Pro Pro Gln Pro Ile Lys Gly Arg Val Val Arg Ala 
                 245                250                255
Ser Phe Lys 
             260



<210> 782
<211> 495
<212> DNA
<213> Homo sapiens
<308> BM713112
<400> 782

ggcatttca  cttggaaac  ttttcctgg  catctaaaa  tattgtgga  ctgagacac  60
gtgcttaca  ggcctactg  ttttcactg  atgagaccg  gaatggatt  tggcagttc  120
tcttacctc  gctgcatac  tgactccat  cacggtgtg  tcagagcca  gatcatccg  180
agagcccca  tgaagatga  actggcgaa  tcggtaggg  ccagggaga  gaccccctc  240
cagcactgt  attcagata  gcttggtca  cagtgaatt  atgcttctt  tacagagct  300
tactttaac  aagtgctct  agagccaag  cttaatgga  aaaatgtgg  cagtttgct  360
ggtggatgg  gccactccc  ggacactgg  ctcctcaca  aatgaagtc  ggggatatg  420
caagataaa  gattgttct  ttctgtctt  cttattttg  ttgcttgtt  cattattat  480
gaaacatca  tttta  495



<210> 783
<211> 259
<212> PRT
<213> Homo sapiens
<308> AAH04897
<400> 783

Ala Lys Glu Trp Gly Tyr Ala Ser His Asn Gly Pro Asp His Trp His 
  1               5                  10                  15
Glu Leu Phe Pro Asn Ala Lys Gly Glu Asn Gln Ser Pro Ile Glu Leu 
             20                  25                  30
His Thr Lys Asp Ile Arg His Asp Pro Ser Leu Gln Pro Trp Ser Val 
         35                  40                  45
Ser Tyr Asp Gly Gly Ser Ala Lys Thr Ile Leu Asn Asn Gly Lys Thr 
     50                  55                  60
Cys Arg Val Val Phe Asp Asp Thr Tyr Asp Arg Ser Met Leu Arg Gly 
 65                  70                  75                  80
Gly Pro Leu Pro Gly Pro Tyr Arg Leu Arg Gln Phe His Leu His Trp 
                 85                  90                  95
Gly Ser Ser Asp Asp His Gly Ser Glu His Thr Val Asp Gly Val Lys 
             100                105                110
Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Pro Lys Tyr Asn Thr 
         115                120                125
Phe Lys Glu Ala Leu Lys Gln Arg Asp Gly Ile Ala Val Ile Gly Ile 
     130                135                140
Phe Leu Lys Ile Gly His Glu Asn Gly Glu Phe Gln Ile Phe Leu Asp 
 145                150                155                160
Ala Leu Asp Lys Ile Lys Thr Lys Gly Lys Glu Ala Pro Phe Thr Lys 
                 165                170                175
Phe Asp Pro Ser Cys Leu Phe Pro Ala Cys Arg Asp Tyr Trp Thr Tyr 
             180                185                190
Gln Gly Ser Phe Thr Thr Pro Pro Cys Glu Glu Cys Ile Val Trp Leu 
         195                200                205
Leu Leu Lys Glu Pro Met Thr Val Ser Ser Asp Gln Met Ala Lys Leu 
     210                215                220
Arg Ser Leu Leu Ser Ser Ala Glu Asn Glu Pro Pro Val Pro Leu Val 
 225                230                235                240
Ser Asn Trp Arg Pro Pro Gln Pro Ile Asn Asn Arg Val Val Arg Ala 
                 245                250                255
Ser Phe Lys 
             260



<210> 784
<211> 1071
<212> DNA
<213> Rattus norvegicus
<308> AF037272
<400> 784

cggcacgag  aggtcactc  tgcagaagg  aagcctgcc  ccagcctcg  gatgggtag  60
tgcgacagg  aagccctct  ggctctgag  ttcctactg  tgctactgg  ctccagctc  120
gttcagggc  cttgggagg  aatgttgcc  gtcaggctg  ctgagaagt  ccaagctga  180
gaggttgca  caacaggct  ccggcagcc  cacgcagac  gctgcccac  accgccacg  240
acgctaccc  cgggtgcct  tcaggccac  cgctgccag  ctgactctg  gtgcccacg  300
cacagacgc  gctgttaca  cggctgtgc  tatgcctgc  tggaggcgg  gccaccgcc  360
ccagttcta  actggctgg  gcagcccaa  ccacggtgg  ttggtggca  tggctggct  420
ctggatggt  cggaggaag  gttacaagc  gaggcctgc  gcaccactg  ggatggggc  480
gagccactc  tctgtccct  aggctatga  tgccacatc  tgcagccag  ggatgcggc  540
cagggcata  ccaaccatg  acggtgtgt  aagcaacgt  gacaagcag  ggggcgggt  600
ctgcgacag  agcttcaca  ggagtaccc  gaaggtgac  ccaagtatg  ggcagagcc  660
gggaaggga  aacagaggc  ctttccatg  agtggagac  ggctgcctt  gtggggcct  720
tcctgtgct  tccacacac  accccttgg  aacagcaaa  gaatttgac  ctagacgtc  780
aactccatt  cacagaacg  gactccaga  ctcctggga  acgggactt  agactccca  840
ccccagagt  gcccagcct  gtgcggcgg  aacttggcg  aagcccctg  ccacctctg  900
gtccccgct  agcatcctt  tcacaggaa  ccgcagctt  taggtgact  ttgcagatt  960
tgcctgcag  aggcatata  tcatctctt  ttttccccg  ataaatctg  ccaccatgt  1020
gcagaaata  gttccttta  caggctcaa  tccnaaaaa  aaaaaaaaa  a  1071



<210> 785
<211> 212
<212> PRT
<213> Rattus norvegicus
<308> AAC40055
<400> 785

Met Gly Ser Cys Asp Arg Lys Ala Leu Trp Ala Leu Ser Phe Leu Leu 
  1               5                  10                  15
Leu Leu Leu Gly Ser Ser Ser Val Gln Gly Thr Trp Glu Ala Met Leu 
             20                  25                  30
Pro Val Arg Leu Ala Glu Lys Ser Gln Ala Glu Glu Val Ala Ala Thr 
         35                  40                  45
Gly Ser Arg Gln Pro His Ala Asp Arg Cys Pro Pro Pro Pro Arg Thr 
     50                  55                  60
Leu Pro Pro Gly Ala Cys Gln Ala Thr Arg Cys Gln Ser Asp Ser Glu 
 65                  70                  75                  80
Cys Pro Arg His Arg Arg Cys Cys Tyr Asn Gly Cys Ala Tyr Ala Cys 
                 85                  90                  95
Leu Glu Ala Val Pro Pro Pro Pro Val Leu Asp Trp Leu Val Gln Pro 
             100                105                110
Lys Pro Arg Trp Leu Gly Gly Asn Gly Trp Leu Leu Asp Gly Pro Glu 
         115                120                125
Glu Val Leu Gln Ala Glu Ala Cys Ser Thr Thr Glu Asp Gly Ala Glu 
     130                135                140
Pro Leu Leu Cys Pro Ser Gly Tyr Glu Cys His Ile Leu Gln Pro Gly 
 145                150                155                160
Asp Ala Ala Gln Gly Ile Pro Asn His Gly Arg Cys Val Lys Gln Arg 
                 165                170                175
Arg Gln Ala Glu Gly Arg Val Leu Arg Gln Lys Leu His Lys Glu Tyr 
             180                185                190
Pro Glu Gly Asp Ser Lys Tyr Val Ala Glu Pro Gly Lys Gly Gln Gln 
         195                200                205
Arg His Phe Pro 
     210



<210> 786
<211> 1366
<212> DNA
<213> Homo sapiens
<308> AF169631
<400> 786

gtgctggac  cggacacat  atccgaggg  ccctgctgg  tggaactaa  aaagtccag  60
agactgtgc  cgctcctgt  cccactcac  ggcccacgc  gcgaggggg  cccctcttc  120
gtgtgcgtc  ggaaggtcg  tgcccaggg  ggaaatgcc  ttaaccggc  tggggccgg  180
cagctgcag  aggcagatc  tccgggctc  gtgcctctt  ctacttctc  tccacgccg  240
ctctgccaa  aatatctgg  aacgggcat  gcctgcgag  ctggccgag  aatcccgtg  300
cgaggaggc  ggcgcgccc  gcggccccc  gcagccccg  gcagaccgc  gcccgccgc  360
tccgcggac  ctgcccccc  gcgcctgcc  ggccgcgcg  tgtcaggcg  actccgagt  420
cccgcggca  cggcgctgc  gctacaacg  atgcgccta  gcctgccta  aagctgtgc  480
gcccccgcc  gtcttagac  ggctggtgc  gccgaaacc  cgatggctt  gtggcaatg  540
ctggctcct  gatggccct  aggaggtgt  acaagcaga  gcgtgcagc  ccacggagg  600
tggggccga  cccctgctc  gtccctcgg  ctatgagtg  cacatcctg  gcccaggtg  660
cgtggccga  ggtatcccc  accgtgggc  gtgcgtcaa  cagcgccgg  aagcagatg  720
gcgaatcct  cgacacaaa  tttacaaag  atatccaga  ggtgactca  agaatgtgg  780
agaacctgg  aggggacaa  agaggcact  tcagtaaag  aacggcaag  agctaggtt  840
caagaacat  cctctactt  ctgctaagc  ttggaaaca  ttgggaaaa  tagtttgac  900
ctcacagtt  acattcagc  cagcagagc  agaccccag  gatgcttag  gacaggaca  960
ctggccatc  aacccagtt  ggcccagcc  ggttgggtg  ctttgtggg  gccacttaa  1020
agctctggg  ccctgtttt  ccatcctgg  agcaaggcc  tgcagctcc  cgagacctt  1080
accccggga  gaagccgcc  cccatgaaa  catttctga  gcccctttc  aagacaagg  1140
tcagcatct  gatattttt  acagattcc  cccaagtct  gctctggga  gtatgtacc  1200
atctcaaat  ttcccaaga  aaattcatc  ttcaggaaa  ggaaatgaa  ttgcttact  1260
atgtgtgat  cctagttgt  gccaccgga  gtgctgagg  ctaaatgtt  gcaggtggg  1320
ggaggccac  gaacaataa  aacaaccaa  taaaaaaaa  aaaaaa  1366



<210> 787
<211> 221
<212> PRT
<213> Homo sapiens
<308> AF169631
<400> 787

Met Pro Leu Thr Gly Val Gly Pro Gly Ser Cys Arg Arg Gln Ile Ile 
  1               5                  10                  15
Arg Ala Leu Cys Leu Leu Leu Leu Leu Leu His Ala Gly Ser Ala Lys 
             20                  25                  30
Asn Ile Trp Lys Arg Ala Leu Pro Ala Arg Leu Ala Glu Lys Ser Arg 
         35                  40                  45
Ala Glu Glu Ala Gly Ala Pro Gly Gly Pro Arg Gln Pro Arg Ala Asp 
     50                  55                  60
Arg Cys Pro Pro Pro Pro Arg Thr Leu Pro Pro Gly Ala Cys Gln Ala 
 65                  70                  75                  80
Ala Arg Cys Gln Ala Asp Ser Glu Cys Pro Arg His Arg Arg Cys Cys 
                 85                  90                  95
Tyr Asn Gly Cys Ala Tyr Ala Cys Leu Glu Ala Val Pro Pro Pro Pro 
             100                105                110
Val Leu Asp Trp Leu Val Gln Pro Lys Pro Arg Trp Leu Gly Gly Asn 
         115                120                125
Gly Trp Leu Leu Asp Gly Pro Glu Glu Val Leu Gln Ala Glu Ala Cys 
     130                135                140
Ser Thr Thr Glu Asp Gly Ala Glu Pro Leu Leu Cys Pro Ser Gly Tyr 
 145                150                155                160
Glu Cys His Ile Leu Ser Pro Gly Asp Val Ala Glu Gly Ile Pro Asn 
                 165                170                175
Arg Gly Gln Cys Val Lys Gln Arg Arg Gln Ala Asp Gly Arg Ile Leu 
             180                185                190
Arg His Lys Leu Tyr Lys Glu Tyr Pro Glu Gly Asp Ser Lys Asn Val 
         195                200                205
Ala Glu Pro Gly Arg Gly Gln Gln Arg His Phe Gln Ter 
     210                215                220



<210> 788
<211> 1108
<212> DNA
<213> Rattus norvegicus
<308> AF039085
<400> 788

ttgctttta  taacactga  ccccatcag  gccagaagc  ggtgcccgc  gcagttttt  60
acacatgcc  ctttcccta  agctggagg  cttgggttc  atttacagt  ctggggtgg  120
gggataagg  ctagtaaaa  cctctcctc  aagatgccc  tgagggtcg  cggcgacgg  180
gacatggag  gcggggcct  tggcgcggc  aacgcgggc  gctccttcg  cctgcggcg  240
tatgtgtcc  agcctcagg  ggtgacacg  ctcgtgagc  tggtcttgg  cttgatcgt  300
ttctcctgc  tcttcggcg  gggctacat  aaccttcac  catctgacc  gctacactg  360
gtgttcaac  ggaacgaag  tgcctgccg  tacggcagt  ccattgggg  gctggcctt  420
ctggcctca  ccttcttcc  tgtggtgga  gcgtttttc  ctcagataa  caatgccac  480
gaccgcaag  atctggtca  tggtgacct  ctcttctca  ctctctgga  cttcctgtg  540
tttgtcggt  tctgctttc  gaccaacca  tgggcagcc  ccaaacctg  tgacgtgtt  600
gtgggagca  actcagccc  ggctgccat  accttcagt  tcttctcca  cttctcctg  660
ggtgtgctg  cctccctgg  ctaccagcg  tacaaggct  gagtggatg  cttcattca  720
aactatgtg  accccacgc  ggatcccac  acagcctac  cctcctacc  tagtgcctc  780
gtggaaaac  accagcagc  gcccttcac  cagaatgtg  agactactg  gggctacca  840
cctccccca  tgtactgag  agccaggga  aaagaggca  gagggtgct  ggtggggct  900
cccctccac  ctggacttc  ctcaaggtt  gctgtccag  actgtagtc  cttggctgt  960
acagttgac  gcccgagtc  atgcctttc  gcaccccag  agccagagc  cacctgaag  1020
gcccatgcc  agaggggct  caccgccac  cgcctgacc  tcaagggca  ctttgagga  1080
agggtttta  taggcctta  ccccccac  1108



<210> 789
<211> 234
<212> PRT
<213> Rattus norvegicus
<308> O54980
<400> 789

Met Pro Leu Arg Val Gly Gly Asp Gly Asp Met Glu Ser Gly Ala Tyr 
  1               5                  10                  15
Gly Ala Ala Asn Ala Gly Gly Ser Phe Asp Leu Arg Arg Tyr Val Ser 
             20                  25                  30
Gln Pro Gln Val Val Thr Arg Leu Val Ser Met Val Leu Ala Leu Ile 
         35                  40                  45
Val Phe Ser Cys Ile Phe Gly Glu Gly Tyr Ile Asn Leu His Ser Ser 
     50                  55                  60
Asp Gln Leu His Cys Val Phe Asn Arg Asn Glu Asp Ala Cys Arg Tyr 
 65                  70                  75                  80
Gly Ser Ala Ile Gly Val Leu Ala Phe Leu Ala Ser Ala Phe Phe Leu 
                 85                  90                  95
Val Val Asp Ala Phe Phe Ser Gln Ile Ser Asn Ala Thr Asp Arg Lys 
             100                105                110
Tyr Leu Val Ile Gly Asp Leu Leu Phe Ser Ala Leu Trp Thr Phe Leu 
         115                120                125
Trp Phe Val Gly Phe Cys Phe Leu Thr Asn Gln Trp Ala Ala Thr Lys 
     130                135                140
Pro Asp Asp Val Leu Val Gly Ala Asp Ser Ala Arg Ala Ala Ile Thr 
 145                150                155                160
Phe Ser Phe Phe Ser Ile Phe Ser Trp Gly Val Leu Ala Ser Leu Ala 
                 165                170                175
Tyr Gln Arg Tyr Lys Ala Gly Val Asp Ala Phe Ile Gln Asn Tyr Val 
             180                185                190
Asp Pro Thr Pro Asp Pro Thr Thr Ala Tyr Ala Ser Tyr Pro Ser Ala 
         195                200                205
Ser Val Glu Asn Tyr Gln Gln Pro Pro Phe Thr Gln Asn Val Glu Thr 
     210                215                220
Thr Glu Gly Tyr Gln Pro Pro Pro Val Tyr 
 225                230



<210> 790
<211> 1491
<212> DNA
<213> Homo sapiens
<308> AJ002308
<400> 790

gcggcggcg  cagcggcgg  gacggcgac  tggagagcg  ggcctacgg  gcggccaag  60
cgggcggct  cttcgacct  cggcgcttc  tgacgcagc  gcaggtggt  gcgcgcgcc  120
tgtgcttgg  cttcgcctt  atcgtgttc  cctgcatct  tggtgaggg  tacagcaat  180
cccacgagt  taagcagat  tactgcgtg  tcaaccgca  cgaggatgc  tgccgctat  240
gcagtgcca  cggggtgct  gccttcctg  cctcggctt  cttcttggt  gtcgacgcg  300
atttccccc  gatcagcaa  gccactgac  gcaagtacc  ggtcattgg  gacctgctc  360
tctcagctc  ctggacctt  ctgtggttt  ttggtttct  cttcctcac  aaccagtgg  420
cagtcacca  cccgaagga  gtgctggtg  gggccgact  tgtgagggc  gccatcacc  480
tcagcttct  ttccatctt  tcctggggt  tgctggcct  cctggccta  cagcgctac  540
aggctggcg  ggacgactt  atccagaat  acgttgacc  cactccgga  cccaacact  600
cctacgcct  ctacccagg  gcatctgtg  acaactacc  acagccacc  ttcacccag  660
acgcggaga  caccgaggg  taccagccg  cccctgtgt  ctgagcggc  gttagcgtg  720
gaaggggga  agagagggc  ctcccctct  ccctggact  tcccatgag  ctcctggaa  780
tgccagccc  tctctttca  ctgttccat  ctgtgcagc  gacacacag  taaggagcc  840
catagcctg  cgggggctg  cagagccac  ccccaagtg  ctgtgccca  agggcttca  900
tcagccgct  actcctcca  ggcactttt  ggaaagggt  tttagctag  gtttttcct  960
gcttttaat  acctcagcc  cgcctgcag  ggctagaag  cagcaggtg  ccatgtgct  1020
ctgacaagt  cctcagctt  cccccggcc  gggtcaggc  gtgggagcc  ctattatct  1080
cgttctctg  caaagactc  tgggggcca  cacacctgc  ctgtgcagc  gagccggac  1140
aggctcttg  gtcctcact  aggtttgct  cccctgtgc  cactgctgt  tgatctggg  1200
gccaccacc  tgtgccggt  gcctctggg  tgcctcccg  ggtgtgagg  cggggctgg  1260
gctcatggc  cttcctcct  gctcccacc  ctggcagca  ggaagggct  tgcctgaca  1320
cacccagct  tatgtaaat  ttctgcagt  gttacttag  aagcctggg  agggcaggg  1380
tgccccatg  ctcccagac  ctgtctgtg  cgagtgtat  ataaaatcg  gggggagat  1440
cccggcctg  gatgctgtt  ggagacgga  taaatgttt  ctcattcag  a  1491



<210> 791
<211> 224
<212> PRT
<213> Homo sapiens
<308> O43760
<400> 791

Met Glu Ser Gly Ala Tyr Gly Ala Ala Lys Ala Gly Gly Ser Phe Asp 
  1               5                  10                  15
Leu Arg Arg Phe Leu Thr Gln Pro Gln Val Val Ala Arg Ala Val Cys 
             20                  25                  30
Leu Val Phe Ala Leu Ile Val Phe Ser Cys Ile Tyr Gly Glu Gly Tyr 
         35                  40                  45
Ser Asn Ala His Glu Ser Lys Gln Met Tyr Cys Val Phe Asn Arg Asn 
     50                  55                  60
Glu Asp Ala Cys Arg Tyr Gly Ser Ala Ile Gly Val Leu Ala Phe Leu 
 65                  70                  75                  80
Ala Ser Ala Phe Phe Leu Val Val Asp Ala Tyr Phe Pro Gln Ile Ser 
                 85                  90                  95
Asn Ala Thr Asp Arg Lys Tyr Leu Val Ile Gly Asp Leu Leu Phe Ser 
             100                105                110
Ala Leu Trp Thr Phe Leu Trp Phe Val Gly Phe Cys Phe Leu Thr Asn 
         115                120                125
Gln Trp Ala Val Thr Asn Pro Lys Asp Val Leu Val Gly Ala Asp Ser 
     130                135                140
Val Arg Ala Ala Ile Thr Phe Ser Phe Phe Ser Ile Phe Ser Trp Gly 
 145                150                155                160
Val Leu Ala Ser Leu Ala Tyr Gln Arg Tyr Lys Ala Gly Val Asp Asp 
                 165                170                175
Phe Ile Gln Asn Tyr Val Asp Pro Thr Pro Asp Pro Asn Thr Ala Tyr 
             180                185                190
Ala Ser Tyr Pro Gly Ala Ser Val Asp Asn Tyr Gln Gln Pro Pro Phe 
         195                200                205
Thr Gln Asn Ala Glu Thr Thr Glu Gly Tyr Gln Pro Pro Pro Val Tyr 
     210                215                220



<210> 792
<211> 1514
<212> DNA
<213> Rattus norvegicus
<308> AF039583
<400> 792

atgatccgc  cgcgggcgc  ggggactcg  gctccgccg  cgccgccgc  gctgctgtc  60
ctgtcgctg  tgctgctgc  gctgtcccc  actgtaagc  gagactgcg  cccacctcc  120
gacattcct  atgccacgc  aaactcggg  aaacacacc  agtttgccc  ccaaagcca  180
gtgacatat  cgtgtaata  gggcttcaa  caaattcca  acaagccaa  cacagtggt  240
tgccttgaa  atgaccaat  gtctaacta  gaaactttc  gtaataaaa  ctgtagtgc  300
ccactgaga  tgaattatg  atccctcaa  aaggagtat  gtaacatga  ttttttccc  360
attggcacc  ctgtggaat  tgagtgtcg  ccaggattt  aaaaagtaa  ttcacgcac  420
ggaaaatca  cttgccttg  ggaattagt  tggtctcca  ttgttgaat  ttgtaaaaa  480
agagcatgc  ctaatccta  agaactgaa  aatggtcac  tcaacatac  aactgacat  540
ttattcgga  cagaaataa  cttctcatg  gacaaaggg  acaagctgg  cggtgtaac  600
tctacattc  gttctatta  ggggaatgc  gtggactgg  atgacgtat  tccagtgtg  660
acaacaatt  tttgtccag  cccaccaaa  atcaataat  gaagaattc  agaggaaag  720
gactcctac  catatagac  gtcggtgac  tattcctgt  accaaggct  cattctggt  780
ggaaattct  ccgttcatt  tactctgaa  ggtgaagta  gagaatgga  tagtgcacc  840
cccaagtgc  tagagagac  caaggtccc  actaagacc  caccagaag  tgatattcc  900
agtacaatg  ctcatgaat  caccttaat  aattttcca  gtacaagag  cccactgtc  960
cataaaccc  ctacagtta  agttccagg  acaagagtc  agccaacgt  tcacaagcc  1020
actgaagtt  aagttccag  aacacagca  gtacctgtt  ccaagacaa  ggtacgtca  1080
ccaacgaga  catctaaag  cagaggaga  tctaattca  gtggtgacc  ttttatata  1140
ggacataca  gtttaataa  catgacaat  ttgcatgtg  tgctcttac  cactggcta  1200
ttgacgtag  caacgaaga  ttaagaaga  agtatatac  accactgag  atacttcta  1260
tttgttaga  tgtccagga  gaatggata  aataaattt  atagtgttg  tggttctgt  1320
tgctgtcat  gtcttgaag  tgtgctaga  atgataaca  agcaagaag  aaggaggtt  1380
tctggaatg  tcttttcaa  gcatataag  ctcttgaaa  tatttcaaa  ctagacaaa  1440
tcacaatgt  gtgtagtat  ttttctaaa  aaaagtgtg  gaaagtgta  aaaattttt  1500
aggggagag  gaaa  1514



<210> 793
<211> 399
<212> PRT
<213> Rattus norvegicus
<308> AAC77438
<400> 793

Met Ile Arg Thr Arg Ala Pro Gly Thr Arg Ala Pro Pro Pro Pro Pro 
  1               5                  10                  15
Leu Leu Leu Ser Leu Ser Leu Leu Leu Leu Leu Leu Ser Pro Thr Val 
             20                  25                  30
Ser Gly Asp Cys Gly Pro Pro Pro Asp Ile Pro Asn Ala Thr Pro Asn 
         35                  40                  45
Ser Gly Lys His Thr Lys Phe Ala His Gln Ser Gln Val Thr Tyr Ser 
     50                  55                  60
Cys Asn Lys Gly Phe Lys Gln Ile Pro Asp Lys Pro Asn Thr Val Val 
 65                  70                  75                  80
Cys Leu Glu Asn Asp Gln Trp Ser Asn Tyr Glu Thr Phe Cys Asn Lys 
                 85                  90                  95
Thr Cys Ser Ala Pro Leu Arg Leu Asn Tyr Ala Ser Leu Lys Lys Glu 
             100                105                110
Tyr Arg Asn Met Asn Phe Phe Pro Ile Gly Thr Thr Val Glu Phe Glu 
         115                120                125
Cys Arg Pro Gly Phe Gln Lys Val Thr Ser Arg Thr Gly Lys Ser Thr 
     130                135                140
Cys Leu Glu Glu Leu Val Trp Ser Pro Val Val Glu Phe Cys Lys Lys 
 145                150                155                160
Arg Ala Cys Pro Asn Pro Arg Glu Leu Lys Asn Gly His Ile Asn Ile 
                 165                170                175
Pro Thr Asp Ile Leu Phe Gly Ser Glu Ile Ile Phe Ser Cys Asp Lys 
             180                185                190
Gly Tyr Lys Leu Val Gly Val Thr Ser Thr Phe Cys Ser Ile Thr Gly 
         195                200                205
Asn Ala Val Asp Trp Asp Asp Val Phe Pro Val Cys Thr Thr Ile Phe 
     210                215                220
Cys Pro Asp Pro Pro Lys Ile Asn Asn Gly Arg Ile Arg Glu Glu Ser 
 225                230                235                240
Asp Ser Tyr Ala Tyr Arg Gln Ser Val Thr Tyr Ser Cys Asp Gln Gly 
                 245                250                255
Phe Ile Leu Val Gly Asn Ser Ser Val His Cys Thr Leu Asn Gly Glu 
             260                265                270
Val Gly Glu Trp Ser Ser Ala Pro Pro Lys Cys Ile Glu Arg His Lys 
         275                280                285
Val Pro Thr Lys Thr Pro Pro Glu Val Asp Ile Pro Ser Thr Met Pro 
     290                295                300
His Glu Ser Thr Leu Ile Asn Phe Pro Ser Thr Arg Ala Pro Leu Ser 
 305                310                315                320
His Lys Pro Thr Thr Val Lys Val Pro Gly Thr Arg Val Lys Pro Thr 
                 325                330                335
Ser His Lys Pro Thr Glu Val Lys Val Pro Ala Thr Gln His Val Pro 
             340                345                350
Val Ser Lys Thr Thr Val Arg His Pro Thr Arg Thr Ser Lys Asp Arg 
         355                360                365
Gly Glu Ser Asn Ser Gly Gly Asp His Phe Ile Tyr Gly His Thr Cys 
     370                375                380
Leu Ile Thr Met Thr Ile Leu His Val Met Leu Leu Leu Thr Gly 
 385                390                395



<210> 794
<211> 2102
<212> DNA
<213> Homo sapiens
<308> NM_000574
<400> 794

ccgctgggc  tagctgcga  tcggcggag  cccggcggc  cgtccttgt  ctaacccgg  60
gcgccatga  cgtcgcgcg  ccgagcgtg  ccgcggcgc  gcccctcct  ggggagctg  120
cccggctgc  gctgctggt  ctgttgtgc  tgccggccg  gtggggtga  tgtggcctt  180
ccccagatg  acctaatgc  cagccagct  tggaaggcc  tacaagttt  cccgaggat  240
ctgtaataa  gtacaaatg  gaagaaagc  ttgtgaaaa  tcctggcga  aaggactca  300
tgatctgcc  taagggcag  caatggtca  atattgaag  gttctgcaa  cgtagctgc  360
aggtgccaa  aaggctaaa  tctgcatcc  tcaaacagc  ttatatcac  cagaattat  420
ttccagtcg  tactgttgt  gaatatgag  gccgtccag  ttacagaag  gaaccttct  480
tatcaccaa  actaacttg  cttcagaat  taaaatggt  cacagcagt  gaattttgt  540
aaaagaaat  atgccctaa  ccgggagaa  tacgaaatg  tcagattga  gtaccaggt  600
gcatattat  tggtgcaac  atctccttc  catgtaaca  agggtacaa  ttatttggc  660
cgacttcta  tttttgtct  atttcaggc  gctctgtcc  gtggagtga  ccgttgcca  720
agtgcagag  aatttattg  ccagcacca  cacaaattg  caatggaat  attcaaggg  780
aacgtgacc  ttatggata  agacagtct  taacgtatg  atgtaataa  ggattcacc  840
tgattggag  gcactctat  tattgtact  tgaataatg  tgaaggaga  tggagtggc  900
caccacctg  atgcagagg  aaatctcta  cttccaagg  cccaccaac  gttcagaaa  960
ctaccacag  aaatgttcc  actacagaa  tctcaccaa  ttctcagaa  accaccaca  1020
aaaccacca  accaaatgc  caagcaaca  ggagtacac  tgtttccag  acaaccaag  1080
attttcatg  aacaacccc  aataaagga  gtggaacca  ttcaggtac  acccgtctt  1140
tatctgggc  cacgtgttt  acgttgaca  gtttgcttg  gacgctagt  accatgggc  1200
tgctgactt  gccaaagaa  agttaagaa  aaaatacac  caagtatac  gactgttcc  1260
agtttctta  acttatctg  atattggat  aaataaatg  aattgtgct  ttcatttag  1320
atgctttca  tgtctttaa  atgtgttag  aatgtcaac  gagcaagga  aaaaaaggc  1380
gtcctggaa  cacattctt  gcacaccta  acctcttga  aatagaaca  cttgcagaa  1440
tgagagtga  tcctttcct  aaagtgtaa  aaagcatag  gatttgttc  tatttagaa  1500
gggatcacg  ggaaaagag  aggaaagtg  tttttttcc  caagatctg  aatgttatt  1560
ccacttata  aggaaataa  aaatgaaaa  cattatttg  atatcaaaa  caaataaaa  1620
cccaattca  tctcttcta  gcaaaattg  taaagagag  tgaaccaca  tataaagta  1680
tctttggct  taaggcatt  tcatctttc  ttcgggttg  caaaatatt  taaaggtaa  1740
acatgctgg  gaaccaggg  tgttgatgg  gataaggga  gaatataga  tgaaagact  1800
aatcttcct  tgttgcaca  atagagttt  gaaaaagcc  gtgaaaggt  tcttctttg  1860
cttaatgtc  ttaaaagta  ccagagata  tacaatatt  acataagaa  agattatat  1920
ttatttctg  atcgagatg  ccatagtca  atttgtaaa  cttattctt  tgtaatatt  1980
atttatatt  atttatgac  gtgaacatt  tgattttac  tgtaaaaca  gaaaagttg  2040
agaagatat  tgaagaaaa  tgtattttt  ctaaataga  ataaatgat  ccatttttt  2100
gt  2102



<210> 795
<211> 381
<212> PRT
<213> Homo sapiens
<308> P08174
<400> 795

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
  1               5                  10                  15
Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
             20                  25                  30
Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
         35                  40                  45
Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
     50                  55                  60
Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Thr 
 65                  70                  75                  80
Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                 85                  90                  95
Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
             100                105                110
Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
         115                120                125
Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
     130                135                140
Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
 145                150                155                160
Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                 165                170                175
Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
             180                185                190
Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
         195                200                205
Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
     210                215                220
Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
 225                230                235                240
Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                 245                250                255
Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
             260                265                270
Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
         275                280                285
Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
     290                295                300
Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
 305                310                315                320
Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                 325                330                335
Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
             340                345                350
Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
         355                360                365
Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
     370                375                380



<210> 796
<211> 1514
<212> DNA
<213> Rattus norvegicus
<308> AF039583
<400> 796

atgatccgc  cgcgggcgc  ggggactcg  gctccgccg  cgccgccgc  gctgctgtc  60
ctgtcgctg  tgctgctgc  gctgtcccc  actgtaagc  gagactgcg  cccacctcc  120
gacattcct  atgccacgc  aaactcggg  aaacacacc  agtttgccc  ccaaagcca  180
gtgacatat  cgtgtaata  gggcttcaa  caaattcca  acaagccaa  cacagtggt  240
tgccttgaa  atgaccaat  gtctaacta  gaaactttc  gtaataaaa  ctgtagtgc  300
ccactgaga  tgaattatg  atccctcaa  aaggagtat  gtaacatga  ttttttccc  360
attggcacc  ctgtggaat  tgagtgtcg  ccaggattt  aaaaagtaa  ttcacgcac  420
ggaaaatca  cttgccttg  ggaattagt  tggtctcca  ttgttgaat  ttgtaaaaa  480
agagcatgc  ctaatccta  agaactgaa  aatggtcac  tcaacatac  aactgacat  540
ttattcgga  cagaaataa  cttctcatg  gacaaaggg  acaagctgg  cggtgtaac  600
tctacattc  gttctatta  ggggaatgc  gtggactgg  atgacgtat  tccagtgtg  660
acaacaatt  tttgtccag  cccaccaaa  atcaataat  gaagaattc  agaggaaag  720
gactcctac  catatagac  gtcggtgac  tattcctgt  accaaggct  cattctggt  780
ggaaattct  ccgttcatt  tactctgaa  ggtgaagta  gagaatgga  tagtgcacc  840
cccaagtgc  tagagagac  caaggtccc  actaagacc  caccagaag  tgatattcc  900
agtacaatg  ctcatgaat  caccttaat  aattttcca  gtacaagag  cccactgtc  960
cataaaccc  ctacagtta  agttccagg  acaagagtc  agccaacgt  tcacaagcc  1020
actgaagtt  aagttccag  aacacagca  gtacctgtt  ccaagacaa  ggtacgtca  1080
ccaacgaga  catctaaag  cagaggaga  tctaattca  gtggtgacc  ttttatata  1140
ggacataca  gtttaataa  catgacaat  ttgcatgtg  tgctcttac  cactggcta  1200
ttgacgtag  caacgaaga  ttaagaaga  agtatatac  accactgag  atacttcta  1260
tttgttaga  tgtccagga  gaatggata  aataaattt  atagtgttg  tggttctgt  1320
tgctgtcat  gtcttgaag  tgtgctaga  atgataaca  agcaagaag  aaggaggtt  1380
tctggaatg  tcttttcaa  gcatataag  ctcttgaaa  tatttcaaa  ctagacaaa  1440
tcacaatgt  gtgtagtat  ttttctaaa  aaaagtgtg  gaaagtgta  aaaattttt  1500
aggggagag  gaaa  1514



<210> 797
<211> 399
<212> PRT
<213> Rattus norvegicus
<308> AAC77438
<400> 797

Met Ile Arg Thr Arg Ala Pro Gly Thr Arg Ala Pro Pro Pro Pro Pro 
  1               5                  10                  15
Leu Leu Leu Ser Leu Ser Leu Leu Leu Leu Leu Leu Ser Pro Thr Val 
             20                  25                  30
Ser Gly Asp Cys Gly Pro Pro Pro Asp Ile Pro Asn Ala Thr Pro Asn 
         35                  40                  45
Ser Gly Lys His Thr Lys Phe Ala His Gln Ser Gln Val Thr Tyr Ser 
     50                  55                  60
Cys Asn Lys Gly Phe Lys Gln Ile Pro Asp Lys Pro Asn Thr Val Val 
 65                  70                  75                  80
Cys Leu Glu Asn Asp Gln Trp Ser Asn Tyr Glu Thr Phe Cys Asn Lys 
                 85                  90                  95
Thr Cys Ser Ala Pro Leu Arg Leu Asn Tyr Ala Ser Leu Lys Lys Glu 
             100                105                110
Tyr Arg Asn Met Asn Phe Phe Pro Ile Gly Thr Thr Val Glu Phe Glu 
         115                120                125
Cys Arg Pro Gly Phe Gln Lys Val Thr Ser Arg Thr Gly Lys Ser Thr 
     130                135                140
Cys Leu Glu Glu Leu Val Trp Ser Pro Val Val Glu Phe Cys Lys Lys 
 145                150                155                160
Arg Ala Cys Pro Asn Pro Arg Glu Leu Lys Asn Gly His Ile Asn Ile 
                 165                170                175
Pro Thr Asp Ile Leu Phe Gly Ser Glu Ile Ile Phe Ser Cys Asp Lys 
             180                185                190
Gly Tyr Lys Leu Val Gly Val Thr Ser Thr Phe Cys Ser Ile Thr Gly 
         195                200                205
Asn Ala Val Asp Trp Asp Asp Val Phe Pro Val Cys Thr Thr Ile Phe 
     210                215                220
Cys Pro Asp Pro Pro Lys Ile Asn Asn Gly Arg Ile Arg Glu Glu Ser 
 225                230                235                240
Asp Ser Tyr Ala Tyr Arg Gln Ser Val Thr Tyr Ser Cys Asp Gln Gly 
                 245                250                255
Phe Ile Leu Val Gly Asn Ser Ser Val His Cys Thr Leu Asn Gly Glu 
             260                265                270
Val Gly Glu Trp Ser Ser Ala Pro Pro Lys Cys Ile Glu Arg His Lys 
         275                280                285
Val Pro Thr Lys Thr Pro Pro Glu Val Asp Ile Pro Ser Thr Met Pro 
     290                295                300
His Glu Ser Thr Leu Ile Asn Phe Pro Ser Thr Arg Ala Pro Leu Ser 
 305                310                315                320
His Lys Pro Thr Thr Val Lys Val Pro Gly Thr Arg Val Lys Pro Thr 
                 325                330                335
Ser His Lys Pro Thr Glu Val Lys Val Pro Ala Thr Gln His Val Pro 
             340                345                350
Val Ser Lys Thr Thr Val Arg His Pro Thr Arg Thr Ser Lys Asp Arg 
         355                360                365
Gly Glu Ser Asn Ser Gly Gly Asp His Phe Ile Tyr Gly His Thr Cys 
     370                375                380
Leu Ile Thr Met Thr Ile Leu His Val Met Leu Leu Leu Thr Gly 
 385                390                395



<210> 798
<211> 2102
<212> DNA
<213> Homo sapiens
<308> NM_000574
<400> 798

ccgctgggc  tagctgcga  tcggcggag  cccggcggc  cgtccttgt  ctaacccgg  60
gcgccatga  cgtcgcgcg  ccgagcgtg  ccgcggcgc  gcccctcct  ggggagctg  120
cccggctgc  gctgctggt  ctgttgtgc  tgccggccg  gtggggtga  tgtggcctt  180
ccccagatg  acctaatgc  cagccagct  tggaaggcc  tacaagttt  cccgaggat  240
ctgtaataa  gtacaaatg  gaagaaagc  ttgtgaaaa  tcctggcga  aaggactca  300
tgatctgcc  taagggcag  caatggtca  atattgaag  gttctgcaa  cgtagctgc  360
aggtgccaa  aaggctaaa  tctgcatcc  tcaaacagc  ttatatcac  cagaattat  420
ttccagtcg  tactgttgt  gaatatgag  gccgtccag  ttacagaag  gaaccttct  480
tatcaccaa  actaacttg  cttcagaat  taaaatggt  cacagcagt  gaattttgt  540
aaaagaaat  atgccctaa  ccgggagaa  tacgaaatg  tcagattga  gtaccaggt  600
gcatattat  tggtgcaac  atctccttc  catgtaaca  agggtacaa  ttatttggc  660
cgacttcta  tttttgtct  atttcaggc  gctctgtcc  gtggagtga  ccgttgcca  720
agtgcagag  aatttattg  ccagcacca  cacaaattg  caatggaat  attcaaggg  780
aacgtgacc  ttatggata  agacagtct  taacgtatg  atgtaataa  ggattcacc  840
tgattggag  gcactctat  tattgtact  tgaataatg  tgaaggaga  tggagtggc  900
caccacctg  atgcagagg  aaatctcta  cttccaagg  cccaccaac  gttcagaaa  960
ctaccacag  aaatgttcc  actacagaa  tctcaccaa  ttctcagaa  accaccaca  1020
aaaccacca  accaaatgc  caagcaaca  ggagtacac  tgtttccag  acaaccaag  1080
attttcatg  aacaacccc  aataaagga  gtggaacca  ttcaggtac  acccgtctt  1140
tatctgggc  cacgtgttt  acgttgaca  gtttgcttg  gacgctagt  accatgggc  1200
tgctgactt  gccaaagaa  agttaagaa  aaaatacac  caagtatac  gactgttcc  1260
agtttctta  acttatctg  atattggat  aaataaatg  aattgtgct  ttcatttag  1320
atgctttca  tgtctttaa  atgtgttag  aatgtcaac  gagcaagga  aaaaaaggc  1380
gtcctggaa  cacattctt  gcacaccta  acctcttga  aatagaaca  cttgcagaa  1440
tgagagtga  tcctttcct  aaagtgtaa  aaagcatag  gatttgttc  tatttagaa  1500
gggatcacg  ggaaaagag  aggaaagtg  tttttttcc  caagatctg  aatgttatt  1560
ccacttata  aggaaataa  aaatgaaaa  cattatttg  atatcaaaa  caaataaaa  1620
cccaattca  tctcttcta  gcaaaattg  taaagagag  tgaaccaca  tataaagta  1680
tctttggct  taaggcatt  tcatctttc  ttcgggttg  caaaatatt  taaaggtaa  1740
acatgctgg  gaaccaggg  tgttgatgg  gataaggga  gaatataga  tgaaagact  1800
aatcttcct  tgttgcaca  atagagttt  gaaaaagcc  gtgaaaggt  tcttctttg  1860
cttaatgtc  ttaaaagta  ccagagata  tacaatatt  acataagaa  agattatat  1920
ttatttctg  atcgagatg  ccatagtca  atttgtaaa  cttattctt  tgtaatatt  1980
atttatatt  atttatgac  gtgaacatt  tgattttac  tgtaaaaca  gaaaagttg  2040
agaagatat  tgaagaaaa  tgtattttt  ctaaataga  ataaatgat  ccatttttt  2100
gt  2102



<210> 799
<211> 381
<212> PRT
<213> Homo sapiens
<308> P08174
<400> 799

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
  1               5                  10                  15
Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
             20                  25                  30
Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
         35                  40                  45
Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
     50                  55                  60
Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Thr 
 65                  70                  75                  80
Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                 85                  90                  95
Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
             100                105                110
Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
         115                120                125
Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
     130                135                140
Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
 145                150                155                160
Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                 165                170                175
Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
             180                185                190
Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
         195                200                205
Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
     210                215                220
Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
 225                230                235                240
Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                 245                250                255
Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
             260                265                270
Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
         275                280                285
Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
     290                295                300
Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
 305                310                315                320
Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                 325                330                335
Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
             340                345                350
Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
         355                360                365
Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
     370                375                380



<210> 800
<211> 1807
<212> DNA
<213> Rattus norvegicus
<308> AF039584
<400> 800

atgatccgc  cgcgggcgc  ggggactcg  gctccgccg  cgccgccgc  gctgctgtc  60
ctgtcgctg  tgctgctgc  gctgtcccc  actgtaagc  gagactgcg  cccacctcc  120
gacattcct  atgccacgc  aaactcggg  aaacacacc  agtttgccc  ccaaagcca  180
gtgacatat  cgtgtaata  gggcttcaa  caaattcca  acaagccaa  cacagtggt  240
tgccttgaa  atgaccaat  gtctaacta  gaaactttc  gtaataaaa  ctgtagtgc  300
ccactgaga  tgaattatg  atccctcaa  aaggagtat  gtaacatga  ttttttccc  360
attggcacc  ctgtggaat  tgagtgtcg  ccaggattt  aaaaagtaa  ttcacgcac  420
ggaaaatca  cttgccttg  ggaattagt  tggtctcca  ttgttgaat  ttgtaaaaa  480
agagcatgc  ctaatccta  agaactgaa  aatggtcac  tcaacatac  aactgacat  540
ttattcgga  cagaaataa  cttctcatg  gacaaaggg  acaagctgg  cggtgtaac  600
tctacattc  gttctatta  ggggaatgc  gtggactgg  atgacgtat  tccagtgtg  660
acaacaatt  tttgtccag  cccaccaaa  atcaataat  gaagaattc  agaggaaag  720
gactcctac  catatagac  gtcggtgac  tattcctgt  accaaggct  cattctggt  780
ggaaattct  ccgttcatt  tactctgaa  ggtgaagta  gagaatgga  tagtgcacc  840
cccaagtgc  tagagagac  caaggtccc  actaagacc  caccagaag  tgatattcc  900
agtacaatg  ctcatgaat  caccttaat  aattttcca  gtacaagag  cccactgtc  960
cataaaccc  ctacagtta  agttccagc  acacagcat  tacctgttt  caagacaac  1020
gtacgtcat  caacgagaa  atctaaaga  agaggagag  ctaattcag  tggtgacca  1080
tttatatat  gaaagtttg  cccacaggg  gttaaaaga  attgccatc  ctgtgggag  1140
catagtcca  atttctgga  gagaatctt  tcttataac  gcctgagaa  aactatcaa  1200
atgcagtgc  tatgggtgc  taagggcag  tgggtaaag  cttttaatc  gctggtttt  1260
tggacaccg  taggcatcc  gcatggtcc  tcatatccc  aacagtgct  ctgctctaa  1320
gcagtctta  gacagcttc  ggtcatctg  ccaatcagt  aggtagcac  gagtgcccg  1380
tgtgtcagt  tgtcatttt  gtgacagaa  aaacccagg  acaacagtc  atacagttc  1440
tatccaaag  gcatagtta  cgccatctc  aaccatttt  aggtctctg  cataggcca  1500
acgtgacca  gagccccac  tttcattat  tctttcctt  atctctagt  aagctttaa  1560
cagagttct  ttagaatat  ccctctaca  gcnaatata  tcggcgaag  tacaaaact  1620
tctctgtgt  gtgattcct  ttagcattt  gtcagtatt  tttctttgt  cattatact  1680
actgttact  attaataag  tccacaaat  cctgaacga  atggtaagg  gcattgtta  1740
gtgggaaaa  agccaagta  tgtaccaaa  tcntgggcg  ctgtaaata  cctttcatg  1800
aaagatg  1807



<210> 801
<211> 466
<212> PRT
<213> Rattus norvegicus
<308> AAC77439
<400> 801

Met Ile Arg Thr Arg Ala Pro Gly Thr Arg Ala Pro Pro Pro Pro Pro 
  1               5                  10                  15
Leu Leu Leu Ser Leu Ser Leu Leu Leu Leu Leu Leu Ser Pro Thr Val 
             20                  25                  30
Ser Gly Asp Cys Gly Pro Pro Pro Asp Ile Pro Asn Ala Thr Pro Asn 
         35                  40                  45
Ser Gly Lys His Thr Lys Phe Ala His Gln Ser Gln Val Thr Tyr Ser 
     50                  55                  60
Cys Asn Lys Gly Phe Lys Gln Ile Pro Asp Lys Pro Asn Thr Val Val 
 65                  70                  75                  80
Cys Leu Glu Asn Asp Gln Trp Ser Asn Tyr Glu Thr Phe Cys Asn Lys 
                 85                  90                  95
Thr Cys Ser Ala Pro Leu Arg Leu Asn Tyr Ala Ser Leu Lys Lys Glu 
             100                105                110
Tyr Arg Asn Met Asn Phe Phe Pro Ile Gly Thr Thr Val Glu Phe Glu 
         115                120                125
Cys Arg Pro Gly Phe Gln Lys Val Thr Ser Arg Thr Gly Lys Ser Thr 
     130                135                140
Cys Leu Glu Glu Leu Val Trp Ser Pro Val Val Glu Phe Cys Lys Lys 
 145                150                155                160
Arg Ala Cys Pro Asn Pro Arg Glu Leu Lys Asn Gly His Ile Asn Ile 
                 165                170                175
Pro Thr Asp Ile Leu Phe Gly Ser Glu Ile Ile Phe Ser Cys Asp Lys 
             180                185                190
Gly Tyr Lys Leu Val Gly Val Thr Ser Thr Phe Cys Ser Ile Thr Gly 
         195                200                205
Asn Ala Val Asp Trp Asp Asp Val Phe Pro Val Cys Thr Thr Ile Phe 
     210                215                220
Cys Pro Asp Pro Pro Lys Ile Asn Asn Gly Arg Ile Arg Glu Glu Ser 
 225                230                235                240
Asp Ser Tyr Ala Tyr Arg Gln Ser Val Thr Tyr Ser Cys Asp Gln Gly 
                 245                250                255
Phe Ile Leu Val Gly Asn Ser Ser Val His Cys Thr Leu Asn Gly Glu 
             260                265                270
Val Gly Glu Trp Ser Ser Ala Pro Pro Lys Cys Ile Glu Arg His Lys 
         275                280                285
Val Pro Thr Lys Thr Pro Pro Glu Val Asp Ile Pro Ser Thr Met Pro 
     290                295                300
His Glu Ser Thr Leu Ile Asn Phe Pro Ser Thr Arg Ala Pro Leu Ser 
 305                310                315                320
His Lys Pro Thr Thr Val Lys Val Pro Ala Thr Gln His Val Pro Val 
                 325                330                335
Ser Lys Thr Thr Val Arg His Pro Thr Arg Thr Ser Lys Asp Arg Gly 
             340                345                350
Glu Ser Asn Ser Gly Gly Asp His Phe Ile Tyr Gly Lys Phe Asp Pro 
         355                360                365
Gln Gly Val Lys Arg Asn Cys His His Cys Gly Arg His Ser Pro Tyr 
     370                375                380
Phe Trp Lys Arg Ile Phe Ser Tyr Asn Cys Leu Arg Lys Thr Ile Lys 
 385                390                395                400
Met Gln Cys Leu Trp Val Pro Lys Gly Arg Trp Val Lys Pro Phe Asn 
                 405                410                415
Arg Leu Val Phe Trp Thr Pro Leu Gly Ile Gln His Gly Pro Ser Tyr 
             420                425                430
Pro Gln Gln Cys Ser Cys Ser Lys Ala Val Leu Gly Gln Leu Arg Val 
         435                440                445
Ile Trp Pro Ile Ser Gln Val Ala Leu Ser Ala Arg Cys Val Ser Val 
     450                455                460
Ser Phe 
 465



<210> 802
<211> 1686
<212> DNA
<213> Rattus norvegicus
<308> AF040261
<400> 802

gctccagaa  ccggcgcta  ctggggcgg  ttggcagct  ctggtagaa  cctcaggca  60
aaccatcta  cggctgctg  accagtcaa  tggacttta  gagtataaa  tgtttggag  120
cctggaaag  tgcatacca  ctctactcg  agacgttta  atggactta  actacagga  180
aaaatggga  cagtacgtg  aagaactct  tgagaagtc  tttgacgga  agatggtgg  240
atactggga  gtgaagtac  ctttccctc  gtccaacag  gattatgtc  acacccgcc  300
gcggcgaga  ctggatgtg  acgggagga  gatctacgt  gtcctggcc  agaatatct  360
tgtacctca  tttccggag  agtctgggg  aatccgagt  aagcagtac  agcagagcc  420
ggcgatcga  agcgatggc  agaagggga  cagagtttt  atgtactac  ttgataacc  480
gggtggcca  attccgtcc  ggctcatta  ctgggcagc  aagaatgga  ttccaagct  540
tttgaaaga  atggtgaaa  cgtgtcaga  ctaccacaa  aaaacctaa  gaggagacc  600
ggaccccgg  atccatgaa  gacacctct  gatgtgcta  accaactga  gctcgccct  660
ctgttccca  cttcaaagc  ctacacacc  ccaaggcat  cttgcctct  tccggctcc  720
tcactgact  ctttcccac  ggtcatagt  agagcctac  accttcttc  actgtcgaa  780
ggggggtcc  atacttgtg  atgtttcat  aggaaaatc  ttagtgggg  aaaggagct  840
ttctgttgt  ccatttttg  ggggatgag  gagaagagg  agggtggca  gatataaga  900
cggcccttc  tggaaagca  gctcacttc  gcattctct  ttgcaacta  aagtggctt  960
tggtccaca  ttgaccttc  aggttcgaa  cccacagtg  tgcctgttc  cttgatgcc  1020
cgctgactc  ggctgggat  tgaggtgac  agcaagtgt  gctgtgttt  tacttgggc  1080
tgatcagta  ttgctgtgg  atcagacca  tctgaggag  gtcccaggc  tgactgagc  1140
catgctgag  tgagcaagg  ttcctaatt  tcaacatct  gatcttttt  ctttcccat  1200
atccactga  aaaacgctg  ctatacctc  tgagcagtg  atttcactg  aagccccag  1260
tttccaaag  cagcgtgtg  gtagtacgc  gactgtatc  tactaaagt  acttcccct  1320
ctagagcgt  tggagatgt  gaagggaca  taatggttt  caacagagt  aaattgacg  1380
agtgatttg  tgtgctctc  acctttttt  cgggaattc  acctcttca  aacagggac  1440
ctcagaacc  tgcgtctga  cctcaattt  tgtaggaaa  tagattcag  ggccaagac  1500
cagccttaa  gatctcagg  aaaagttgt  gtcaatcac  ctgtgcaaa  cttgactaa  1560
ggatatgga  actcaagat  caaagacag  ggaaaggat  tgtttgagt  ggatttctt  1620
gagtgtgtg  tctttctgg  aagaaagtt  tgttccatg  ataaacaca  tgacttatg  1680
taaaaa  1686



<210> 803
<211> 214
<212> PRT
<213> Rattus norvegicus
<308> P53809
<400> 803

Met Ala Gly Pro Ala Ala His Phe Ser Asp Glu Gln Phe Arg Glu Ala 
  1               5                  10                  15
Cys Ala Glu Leu Gln Lys Pro Ala Leu Thr Gly Ala Asp Trp Gln Leu 
             20                  25                  30
Leu Val Glu Ala Ser Gly Ile Thr Ile Tyr Arg Leu Leu Asp Gln Ser 
         35                  40                  45
Thr Gly Leu Tyr Glu Tyr Lys Val Phe Gly Val Leu Glu Ser Cys Ile 
     50                  55                  60
Pro Ser Leu Leu Ala Asp Val Tyr Met Asp Leu Asp Tyr Arg Lys Lys 
 65                  70                  75                  80
Trp Asp Gln Tyr Val Lys Glu Leu Tyr Glu Lys Ser Phe Asp Gly Gln 
                 85                  90                  95
Met Val Ala Tyr Trp Glu Val Lys Tyr Pro Phe Pro Leu Ser Asn Arg 
             100                105                110
Asp Tyr Val Tyr Thr Arg Gln Arg Arg Asp Leu Asp Val Asp Gly Arg 
         115                120                125
Lys Ile Tyr Val Val Leu Ala Gln Asn Ile Ser Val Pro Gln Phe Pro 
     130                135                140
Glu Lys Ser Gly Val Ile Arg Val Lys Gln Tyr Lys Gln Ser Leu Ala 
 145                150                155                160
Ile Glu Ser Asp Gly Lys Lys Gly Ser Arg Val Phe Met Tyr Tyr Phe 
                 165                170                175
Asp Asn Pro Gly Gly Gln Ile Pro Ser Trp Leu Ile Asn Trp Ala Ala 
             180                185                190
Lys Asn Gly Val Pro Ser Phe Leu Lys Asp Met Val Lys Ala Cys Gln 
         195                200                205
Asn Tyr His Lys Lys Thr 
     210



<210> 804
<211> 2060
<212> DNA
<213> Homo sapiens
<308> AK058120
<400> 804

agaatgcgc  ggggtcgac  tccccgcag  gagtgcggg  cggcagtcg  ggaagggac  60
ggggcgggt  ttctccggc  caggaagga  ctccgcccg  accctgtct  aagctctgg  120
gctagcgca  gggcggtgc  tccaagtga  tgccgtgca  atccagggg  gttggaagg  180
cacaggagt  cagcctcag  agactggac  ttatgagta  aaagtcttt  gtgttctgg  240
ggactgctc  ccaactcta  tggcagaca  ctatatgga  tcagattac  gaaaacaat  300
ggaccagta  gttaaagaa  tctatgaac  agaatgcaa  ggagagact  tggtctact  360
ggaagtgaa  taccctttt  ccatgtcca  cagagacgt  tcctttcca  aagcttgtg  420
cgctttcct  ctgtctgtc  acaatgctg  cgttggtgt  ttgccttga  tggccatgc  480
gtatgtcta  cttcggcag  ggcgagacc  ggacatgga  gggaggaag  tccatgtga  540
cctggcccg  agcacctcc  tgcctcagc  tggcgagag  tctggggtg  tccgggtga  600
gcaatacaa  cagagcctg  cgattgaga  tgacggcaa  aaggggagc  aagttttca  660
gtattactt  gataacccg  gtggccaaa  tccgtcctg  ctcattaac  gggccgcca  720
gaatggagt  cctaacttc  tgaaagaca  ggcaagagc  tgtcagaac  acctcaaga  780
aacctaaga  agagaactg  gaacattgc  tccatgggt  gatgtctct  gaagtgcaa  840
cacccaatg  ctctggaag  gccacctgg  agtgccacc  ggaagtgtc  ctggaagag  900
acccaccac  gttcagcct  cccctgctg  ttctgtctt  agaggccta  acactacca  960
atcctttct  agcatgttt  cctgacatc  agctcactc  tctgcttcc  ttctcgctc  1020
ccccatcct  ggctgggct  ccttcttct  cagttcaat  tggggcaga  tagggaaac  1080
tttgcttgc  tactattag  aggggaagt  ttcagtagg  aacacgatc  ttccattgt  1140
caattttac  gggatgggt  ggcggaggg  cacaacaaa  tttaagaat  actatttgg  1200
cgggctggc  cttttgcag  ttgtgattt  ttccagctt  ggaggggct  ctggaagtg  1260
catttcgtt  agagctgac  ttcagtgca  ccaaactgg  tgacgtgcc  atgtccatt  1320
gccttatgc  ttgtggagc  gattaggct  ggatttgag  tgataatcc  gtaagtctt  1380
cctcgttcc  acttgtgga  gatcagtag  tgttatgat  ccagaccat  tggagaagt  1440
tcagaggcc  gaccggaca  ataatacga  aaccacatt  ttcctcatc  tccatgagg  1500
aatggatga  ttctctttt  catatgtca  tgggggaaa  gctgcctgt  cctctcaag  1560
tttgcattt  actggaaac  gaggcgtca  gatggctgt  gcagctagc  aaagcaaag  1620
tgctttgtg  atagccttg  gaaaaagta  ctttctatg  aataagatg  attttcctc  1680
cagaatatt  agaaatgta  aagggataa  agttcacag  caggtaaaa  ttaactggt  1740
gcttaatga  tctgcacct  tttctcagg  attctgcct  agttgtctg  cttttctac  1800
accaaaaag  cttttagtt  tctatgctt  ctcctgaat  ttggtaggg  aaggtattt  1860
tatgtcaaa  gcacagcct  gatgatctc  gggaaaaat  ttaatcact  tgtataatg  1920
tactgaacc  tgattaata  cagaaattc  ggatgtaaa  ccacagaat  ggatttatt  1980
atgtgggat  cctcagact  tttgttttc  ttctgggaa  aaaagtgtg  tctataatg  2040
ataaatata  agtggttttt  2060



<210> 805
<211> 214
<212> PRT
<213> Homo sapiens
<308> Q9UKL6
<400> 805

Met Glu Leu Ala Ala Gly Ser Phe Ser Glu Glu Gln Phe Trp Glu Ala 
  1               5                  10                  15
Cys Ala Glu Leu Gln Gln Pro Ala Leu Ala Gly Ala Asp Trp Gln Leu 
             20                  25                  30
Leu Val Glu Thr Ser Gly Ile Ser Ile Tyr Arg Leu Leu Asp Lys Lys 
         35                  40                  45
Thr Gly Leu Tyr Glu Tyr Lys Val Phe Gly Val Leu Glu Asp Cys Ser 
     50                  55                  60
Pro Thr Leu Leu Ala Asp Ile Tyr Met Asp Ser Asp Tyr Arg Lys Gln 
 65                  70                  75                  80
Trp Asp Gln Tyr Val Lys Glu Leu Tyr Glu Gln Glu Cys Asn Gly Glu 
                 85                  90                  95
Thr Val Val Tyr Trp Glu Val Lys Tyr Pro Phe Pro Met Ser Asn Arg 
             100                105                110
Asp Tyr Val Tyr Leu Arg Gln Arg Arg Asp Leu Asp Met Glu Gly Arg 
         115                120                125
Lys Ile His Val Ile Leu Ala Arg Ser Thr Ser Met Pro Gln Leu Gly 
     130                135                140
Glu Arg Ser Gly Val Ile Arg Val Lys Gln Tyr Lys Gln Ser Leu Ala 
 145                150                155                160
Ile Glu Ser Asp Gly Lys Lys Gly Ser Lys Val Phe Met Tyr Tyr Phe 
                 165                170                175
Asp Asn Pro Gly Gly Gln Ile Pro Ser Trp Leu Ile Asn Trp Ala Ala 
             180                185                190
Lys Asn Gly Val Pro Asn Phe Leu Lys Asp Met Ala Arg Ala Cys Gln 
         195                200                205
Asn Tyr Leu Lys Lys Thr 
     210



<210> 806
<211> 4258
<212> DNA
<213> Rattus norvegicus
<308> AF041106
<400> 806

ttttcgcgg  cctgaaatc  ggaacgtca  tgttgagcg  gccaaagta  ataaagagg  60
cacgagccc  aaactgcct  ctcttaata  tgagactgg  ggcagcagc  ctaatgttc  120
tgacctgat  gatgagttt  tcgcagagc  acttcgaag  ggcaatgcc  cgactatga  180
aagaagggg  agtagtcca  gcagccttg  aattccgaa  gaccttcct  atattctaa  240
caagcagaa  cagatgcgc  ctgttgatg  ccctggtgt  ccctcggaa  ggacgtctc  300
tgccagtgc  gggagcagt  atctcatga  ctcagatag  cactcggat  ccttcagtg  360
cttccagtg  gagggccga  aatttgaca  ctttggctt  gggactgac  ttgggatcc  420
atcttctgc  gatgtggat  caggctctg  ccatcatca  agcactgag  agcaggaag  480
ggctagcct  acgacgctt  atttagact  agagacaag  agccttaat  aacaagcat  540
ctctgctga  gttgcaact  tcactggtt  agaaagtgc  tcccctgtt  attcagctc  600
ggggtccag  tcacagaca  cttcccctt  tacgctgaa  atagatcac  tggaacaga  660
ggatctaca  cttgatgag  agctccacc  ctctgttct  cagacgcca  atgacctag  720
aatcagtga  tttccttct  aatgttgta  tgtgatggc  ggaggtacg  tcactgggt  780
gcatgctga  gttgctact  ttatgtggc  aagaatgct  ggcattttg  gagatgtca  840
tgctattat  gatcctgaa  tacatgctc  agtttttga  tacctctgt  aactttggc  900
gaatctagc  aagatcaga  ataatcttg  catttcagc  gataacctg  cttcacctt  960
tccacctgt  ttgattcct  cactaagaa  tcttacacc  tggcttttt  aggcaacca  1020
gttgactga  aagtataaa  aaggtaaat  acatgcatt  tggattgct  catattgac  1080
aggacatcg  caatacgat  atcaagcac  gctcacctc  gtttttttc  cttggtttg  1140
ctggggcca  aatgcttat  atggatttt  ttatagcgg  tgggagagt  gcttcttca  1200
cttttctta  tgcaccaag  gtggaagca  aggttcttc  gggatcttt  gtttgcttc  1260
ccaacttat  ctgtgagct  cctgctctg  atccaagca  gcctgacat  gctgtgtct  1320
agttcacag  cgtcaagga  cttataatt  aaactgtct  aagctcggc  agagacgaa  1380
cctctggcc  tgcacgatg  gtagcactt  gcagtttag  tatatggat  tgtgaagaa  1440
tagtccacg  atctcatca  cctcaaatt  aagaagcac  gaatgtaat  tgtgtttca  1500
taaagttta  taataaaac  gttgcccat  tagcttgta  catgcttca  atgctggtt  1560
attatgcac  tagacttca  acttaccag  ctgactctc  cttgaaaat  attcagatc  1620
taatagcaa  tatcacaca  cttttgcca  gtacagaag  ttcatcata  gaaatggac  1680
agaggttgg  tgtgtcatt  cttctttgc  ttctggact  gatcatggc  ttaccttta  1740
agacactac  ccaatcagt  cattctaca  gagcagaaa  tgagaagac  gaaaaatct  1800
tcctcaact  tatttataa  gttttacat  ggtgtgtat  tggagcaca  agttttagc  1860
atccaaagt  ctttccaat  agcctttct  atttggcat  tgtagatta  gaccctttt  1920
tgcatttgg  aagtctgag  gagcctgaa  ctctacact  tcctgattc  gaacggtct  1980
ctaaactgc  gccggtgac  gaagtgaaa  ctcagatgc  acaaggatt  atttctata  2040
cagcccgta  tgttattac  catctggtg  atcacctgg  ccattatcc  atgagtggt  2100
gtcctgcta  gctaacgag  caggtgtgt  agaatcatg  caatcatta  agcgaaagt  2160
ctgaacttt  tcctgagct  tttgacagt  caaatattc  gttctttgt  ctgaataat  2220
caaccttag  gtcttgtat  cagataaga  cagaagaga  tgtgcctgg  ggaggttta  2280
ctgctggcc  tgtgtcagc  aactcaaat  ttagaatca  agtacgtga  ctctctgga  2340
agtactcat  ggattctgc  atactgtat  ggccaccca  tgtaagtgg  ttgcctgaa  2400
ctacatctt  catactttc  atgtcttac  aagagaaac  agaagaacc  cctacatct  2460
atgaatgct  agaagacat  acagtaaaa  atggacttt  tctccagct  agaagattt  2520
gagaaactg  tccaacttg  tctacaata  gagaagaag  agatgttct  gatgagctc  2580
tgcagtatt  acgcactac  agtcctgaa  gtttacaga  aactggaat  tccctcaat  2640
ttcctgctc  acaacctgt  tgcatttct  aaaaacagg  gaatgatgt  attaatgct  2700
tccttaagc  atacacaga  gaaaaagag  ttgtagaaa  gcactttaa  gacttaaac  2760
tgaaagcct  agaacaaga  gaaccaaca  ctcagaaac  tcagtcagc  ttttattac  2820
gcagattgc  tcttagtat  ttgggaatg  attcctggg  caaacggag  agctttcat  2880
tcctgaaga  aaatgaaaa  ctgctcaga  aactgagga  cttggattc  aggcagtgc  2940
gagaaacac  caagattgc  gtattttac  ttgctgaag  acaagaaga  aaatactcc  3000
ttctcacca  tataggagg  agccaagca  atgaagatt  tgttgctgg  cttggttgg  3060
aggtaaacc  tacaaatca  tgtggcttc  tgggaggac  gcagaagaa  aaaagcact  3120
gactgacca  tccatattt  gctacctct  cagtagaag  aatatttca  gtatctaca  3180
gaatgcctt  tgaatctga  gactctctg  ccaaaaaaa  aaattggag  attgctctt  3240
ctttctcta  aaaggattc  gttggaatt  tgatgggga  tccattgac  ctgtagatt  3300
ctttagttg  gacatctag  aaatgatga  gtacacatt  tttggtctg  acatactag  3360
gactacagg  gaggaatta  tcctacaga  tttggtgat  tcctcattg  aatatatcc  3420
atgaaaaac  acatgttca  tatccagat  atgaaaaag  cagaggttc  cttctttgg  3480
ccccttttt  atggtgcta  tgtgaatgg  aaagttctg  ccattatgg  tcgatccac  3540
gcaataaat  ctagccgtg  tctgaaatc  ctgattcca  tgtatcaaa  cttctacga  3600
gagagagca  ggtacctgc  gacaattgt  cagcaccac  tagagccaa  gacatttga  3660
gactttgca  cccaggttt  ctctccagc  ccctaccat  atttccctg  tgatgcaga  3720
cattaagtg  cagttctgt  tatctgaag  atcctaccc  gagatcgca  ccagtgacg  3780
tcccacagc  gcacaggta  atggggctg  cctggcttc  cccatgtct  ctcgaacta  3840
caaaagccg  atgtccatg  agctgcgtc  gtcctctgg  tcagccaat  aatcctaag  3900
agacaggca  cctggcagc  cagcagcag  gttaactct  ccaggcctt  tgttcgcca  3960
gctccttcc  gtgcattta  ttgagaaaa  actggactt  aaataattt  caacttact  4020
ttttaaatt  ggactactt  tttaattca  tttttttcc  cactgcaag  tgccgtatt  4080
tgagggttg  gttttattc  atacttcac  ttcctagat  atcatgtct  agtagtgtt  4140
ccttcaagt  catgatgaa  gttgagcca  aatatgatt  gacagatag  ctcgtgtta  4200
ttattgtgc  tcattacaa  ctatgtgtt  attgaatct  gtgccgaat  cctgcagc  4258



<210> 807
<211> 747
<212> PRT
<213> Rattus norvegicus
<308> AAB97075
<400> 807

Met His Cys Gly Leu Leu His Ile Asp Gln Asp Ile Val Asn Thr Ile 
  1               5                  10                  15
Ile Lys His Cys Ser Pro Gln Phe Phe Ser Leu Gly Leu Pro Gly Ala 
             20                  25                  30
Thr Met Leu Ile Met Asp Phe Ile Ile Ala Ala Gly Arg Val Ala Ser 
         35                  40                  45
Ser Ala Phe Leu Asn Ala Pro Arg Val Glu Ala Gln Val Leu Leu Gly 
     50                  55                  60
Ser Leu Val Cys Phe Pro Asn Leu Tyr Cys Glu Leu Pro Ala Leu His 
 65                  70                  75                  80
Pro Ser Thr Pro Asp Ile Ala Val Ser Gln Phe Thr Asp Val Lys Glu 
                 85                  90                  95
Leu Ile Ile Lys Thr Val Leu Ser Ser Ala Arg Asp Glu Pro Ser Gly 
             100                105                110
Pro Ala Arg Cys Val Ala Leu Cys Ser Leu Gly Ile Trp Ile Cys Glu 
         115                120                125
Glu Leu Val His Glu Ser His His Pro Gln Ile Lys Glu Ala Leu Asn 
     130                135                140
Val Ile Cys Val Ser Leu Lys Phe Thr Asn Lys Thr Val Ala His Val 
 145                150                155                160
Ala Cys Asn Met Leu His Met Leu Val His Tyr Ala Pro Arg Leu Gln 
                 165                170                175
Thr Tyr Gln Pro Asp Ser Pro Leu Lys Ile Ile Gln Ile Leu Ile Ala 
             180                185                190
Thr Ile Thr His Leu Leu Pro Ser Thr Glu Ala Ser Ser Tyr Glu Met 
         195                200                205
Asp Lys Arg Leu Val Val Ser Leu Leu Leu Cys Leu Leu Asp Trp Ile 
     210                215                220
Met Ala Leu Pro Leu Lys Thr Leu Leu Gln Ser Val His Ser Thr Gly 
 225                230                235                240
Ala Glu Asn Glu Lys Thr Glu Lys Ser Val Leu Asn Cys Ile Tyr Lys 
                 245                250                255
Val Leu His Gly Cys Val Tyr Gly Ala Gln Ser Phe Ser His Pro Lys 
             260                265                270
Tyr Phe Pro Ile Ser Leu Ser Asp Leu Ala Ser Val Asp Tyr Asp Pro 
         275                280                285
Phe Met His Leu Glu Ser Leu Arg Glu Pro Glu Pro Leu His Ser Pro 
     290                295                300
Asp Ser Glu Arg Ser Ser Lys Leu Gln Pro Val Thr Glu Val Lys Thr 
 305                310                315                320
Gln Met Gln Gln Gly Leu Ile Ser Ile Ala Ala Arg Thr Val Ile Thr 
                 325                330                335
His Leu Val Asn His Leu Gly His Tyr Pro Met Ser Gly Gly Pro Ala 
             340                345                350
Met Leu Thr Ser Gln Val Cys Glu Asn His Asp Asn His Tyr Ser Glu 
         355                360                365
Ser Thr Glu Leu Ser Pro Glu Leu Phe Asp Ser Pro Asn Ile Gln Phe 
     370                375                380
Phe Val Leu Asn Asn Thr Thr Leu Val Ser Cys Ile Gln Ile Arg Ser 
 385                390                395                400
Glu Glu Ser Val Pro Gly Gly Gly Leu Ala Ala Gly Leu Val Ser Ala 
                 405                410                415
Asn Ser Asn Val Arg Ile Ile Val Arg Asp Leu Ser Gly Lys Tyr Ser 
             420                425                430
Trp Asp Ser Ala Ile Leu Tyr Gly Pro Pro Ile Val Ser Gly Leu Pro 
         435                440                445
Glu Pro Thr Ser Phe Ile Leu Ser Met Ser Tyr Gln Glu Lys Pro Glu 
     450                455                460
Glu Pro Pro Thr Ser Asn Glu Cys Leu Glu Asp Ile Thr Val Lys Asp 
 465                470                475                480
Gly Leu Ser Leu Gln Leu Arg Arg Phe Arg Glu Thr Val Pro Thr Trp 
                 485                490                495
Ser Thr Ile Arg Glu Glu Glu Asp Val Leu Asp Glu Leu Leu Gln Tyr 
             500                505                510
Leu Arg Thr Thr Ser Pro Glu Cys Leu Gln Arg Thr Gly Ile Ser Leu 
         515                520                525
Asn Val Pro Ala Pro Gln Pro Val Cys Ile Ser Glu Lys Gln Glu Asn 
     530                535                540
Asp Val Ile Asn Ala Ile Leu Lys Gln Tyr Thr Glu Glu Lys Glu Phe 
 545                550                555                560
Val Glu Lys His Phe Asn Asp Leu Asn Met Lys Ala Ser Glu Gln Asp 
                 565                570                575
Glu Pro Thr Pro Gln Lys Pro Gln Ser Ala Phe Tyr Tyr Cys Arg Leu 
             580                585                590
Leu Leu Ser Ile Leu Gly Met Asn Ser Trp Asp Lys Arg Arg Ser Phe 
         595                600                605
His Leu Leu Lys Lys Asn Glu Lys Leu Leu Arg Glu Leu Arg Asn Leu 
     610                615                620
Asp Ser Arg Gln Cys Arg Glu Thr His Lys Ile Ala Val Phe Tyr Val 
 625                630                635                640
Ala Glu Gly Gln Glu Asp Lys Tyr Ser Ile Leu Thr Asn Ile Gly Gly 
                 645                650                655
Ser Gln Ala Tyr Glu Asp Phe Val Ala Gly Leu Gly Trp Glu Val Asn 
             660                665                670
Leu Thr Asn His Cys Gly Phe Met Gly Gly Leu Gln Lys Asn Lys Ser 
         675                680                685
Thr Gly Leu Thr Thr Pro Tyr Phe Ala Thr Ser Thr Val Glu Val Ile 
     690                695                700
Phe His Val Ser Thr Arg Met Pro Ser Glu Ser Asp Asp Ser Leu Thr 
 705                710                715                720
Lys Lys Ile Asn Trp Arg Ile Ala Leu Ser Phe Ser Ile Lys Asp Ser 
                 725                730                735
Val Gly Ile Leu Met Gly Ile Pro Leu Thr Leu 
             740                745



<210> 808
<211> 2121
<212> DNA
<213> Homo sapiens
<308> AL050050
<400> 808

aaagatgga  tttccagtt  aaaagattt  gagaaactg  accaacttg  gatacaata  60
gagatgaag  agatgctct  gatgaactc  tgcagtatt  gggtgttac  agtcctgaa  120
gcttacaga  aactggaat  tcacttaat  ttcctgctc  acaacctgt  tgcatttct  180
aaaaacaag  aagtgatgt  attaatgct  tccttaagc  acatacaga  gaaaaagaa  240
ttgttgaga  gcactttaa  gacttaaac  tgaaagctg  ggaacaaga  gaaccaata  300
ctcaaaaac  tcagtcagc  ttttattat  gcagattgc  tcttagtat  ttgggaatg  360
attcctggg  caaacggag  agctttcat  tcctgaaga  aaatgaaaa  ctacttaga  420
aacttagga  cttggattc  aggcagtgc  gagagacac  caagattgc  gtattttat  480
ttgctgaag  acaagaaga  aaacactcc  ttctcacca  tacaggagg  agtcaagca  540
atgaagatt  tgtagctgg  cttggttgg  aggtaaatc  tacaaacca  tgtggtttt  600
tgggaggac  acaaaaaaa  aaaagcact  gattgacca  tccatattt  gctacctct  660
cagtagaag  aatatttca  atgtcaaca  gaatgcctt  tgattctga  gattctttg  720
ccaaaaaat  gagacattt  ggaaatgat  aagtgcaca  tgtttggtc  gagcatact  780
gagactaca  gagaggaat  attcccaca  aatttggtg  tgtccttat  gtaatatat  840
caatgaaaa  tcacatgtt  agtattcag  taatgagaa  accagaggt  cccttcttt  900
gtccccttt  tgatggtgc  attgtgaat  gaaaggttc  acccattat  gttagagca  960
cagctataa  tgcaagccg  gctctgaaa  ctctgattc  attgtatca  aacttctat  1020
aggagagag  acgatacct  caaacaatt  tccagcacc  cttagaacc  acaacattt  1080
aagattttg  agcacaggt  ttttctcca  ctccctacc  ccatttacc  tctggtgcc  1140
atcattaaa  atcagttct  tttatctga  ggctcctac  cagagattc  acccagtga  1200
actcccaca  cagcgcagg  agatggggc  gacctggcc  ctccaatgt  tcctcgaac  1260
agcaaaagc  gcatgtcca  gaagctgcg  cgttcctct  gctcagcca  taaatccta  1320
ggagacaag  agcccagca  tgatcagca  tagccacct  agcatggac  tagggttaa  1380
cctttcagg  cttcatgtc  gccataaca  gcatgtttc  tcctgtaca  ttatttgag  1440
aaacactgg  tttaaataa  tttaaataa  ttgtagctt  atattaaag  tttaagtta  1500
ttattgttt  atttttttc  cacaatcca  gctgccata  tttgagggc  gggggagtt  1560
tattctaca  cctttacct  cctagataa  tatgtctaa  tagttttat  tttaatttc  1620
tggttaact  tgagccaaa  tacaattgg  caattagtc  cattattta  tgtgctcca  1680
tgcaacttt  tggttcaat  aatatataa  tttttacaa  tgtaaaatt  tacatttaa  1740
catttgtaa  gttacagca  aagatgtac  tgttaatac  cagaatgtg  acagattat  1800
tgttatgac  ataaaacac  caaaataaa  ggtctttag  atctcaaat  ccaactgaa  1860
tcattttag  attaactct  cttcccaaa  caatgtctc  tttcttggc  gtgcaggtg  1920
tgccatgtt  tatccaata  ctagaaaaa  cactgtgct  aacttttat  tttagcttc  1980
aagtatttt  ctaatgttt  gcatttcaa  tggtatcac  gttaaatgc  atttgtttt  2040
agattgtgg  cttttatta  tggctgcta  atcctggtg  ttctatgtt  ttttttaag  2100
accaaaaaa  aaaaaaaaa  a  2121



<210> 809
<211> 1023
<212> PRT
<213> Homo sapiens
<308> BAA86586
<400> 809

Thr Ile Leu Val Arg Arg Ser Ser Ser Pro Ala Glu Leu Asp Leu Lys 
  1               5                  10                  15
Asp Asp Leu Gln Gln Thr Gln Gly Lys Cys Arg Glu Arg Gln Lys Ser 
             20                  25                  30
Glu Ser Thr Asn Ser Asp Thr Thr Leu Gly Cys Thr Asn Glu Ala Glu 
         35                  40                  45
Leu Ser Met Gly Pro Trp Gln Thr Cys Glu Glu Asp Pro Glu Leu Asn 
     50                  55                  60
Thr Pro Thr Asp Val Val Ala Asp Ala Asp Ala Arg His Trp Leu Gln 
 65                  70                  75                  80
Leu Ser Pro Thr Asp Ala Ser Asn Leu Thr Asp Ser Ser Glu Cys Leu 
                 85                  90                  95
Thr Asp Asp Cys Ser Ile Ile Ala Gly Gly Ser Leu Thr Gly Trp His 
             100                105                110
Pro Asp Ser Ala Ala Val Leu Trp Arg Arg Val Leu Gly Ile Leu Gly 
         115                120                125
Asp Val Asn Asn Ile Gln Ser Pro Lys Ile His Ala Arg Val Phe Cys 
     130                135                140
Tyr Leu Tyr Glu Leu Trp Tyr Lys Leu Ala Lys Ile Arg Asp Asn Leu 
 145                150                155                160
Ala Ile Ser Leu Asp Asn Gln Ser Ser Pro Ser Pro Pro Val Leu Ile 
                 165                170                175
Pro Pro Leu Arg Met Phe Ala Ser Trp Leu Phe Lys Ala Ala Thr Leu 
             180                185                190
Pro Asn Glu Tyr Lys Glu Gly Lys Leu Gln Ala Tyr Arg Leu Ile Cys 
         195                200                205
Ala Met Met Thr Arg Arg Gln Asp Val Leu Pro Asn Ser Asp Phe Leu 
     210                215                220
Val His Phe Tyr Leu Val Met His Leu Gly Leu Thr Ser Glu Asp Gln 
 225                230                235                240
Asp Ile Leu Asn Thr Ile Ile Arg His Cys Pro Pro Arg Phe Phe Ser 
                 245                250                255
Leu Gly Phe Pro Gly Phe Ser Met Leu Val Gly Asp Phe Ile Thr Ala 
             260                265                270
Ala Ala Arg Val Leu Ser Thr Asp Ile Leu Thr Ala Pro Arg Ser Glu 
         275                280                285
Ala Val Thr Val Leu Gly Ser Leu Val Cys Phe Pro Asn Thr Tyr Gln 
     290                295                300
Glu Ile Pro Leu Leu Gln Ser Val Pro Glu Val Asn Glu Ala Ile Thr 
 305                310                315                320
Gly Thr Glu Asp Val Lys His Tyr Leu Ile Asn Ile Leu Leu Lys Asn 
                 325                330                335
Ala Thr Glu Glu Pro Asn Glu Tyr Ala Arg Cys Ile Ala Val Cys Ser 
             340                345                350
Leu Gly Val Trp Ile Cys Glu Glu Leu Ala Gln Cys Thr Ser His Pro 
         355                360                365
Gln Val Lys Glu Ala Ile Asn Val Ile Gly Val Thr Leu Lys Phe Pro 
     370                375                380
Asn Lys Ile Val Ala Gln Val Ala Cys Asp Val Leu Gln Leu Leu Val 
 385                390                395                400
Ser Tyr Trp Glu Lys Leu Gln Met Phe Glu Thr Ser Leu Pro Arg Lys 
                 405                410                415
Met Ala Glu Ile Leu Val Ala Thr Val Ala Phe Leu Leu Pro Ser Ala 
             420                425                430
Glu Tyr Ser Ser Val Glu Thr Asp Lys Lys Phe Ile Val Ser Leu Leu 
         435                440                445
Leu Cys Leu Leu Asp Trp Cys Met Ala Leu Pro Val Ser Val Leu Leu 
     450                455                460
His Pro Val Ser Thr Ala Val Leu Glu Glu Gln His Ser Ala Arg Ala 
 465                470                475                480
Pro Leu Leu Asp Tyr Ile Tyr Arg Val Leu His Cys Cys Val Cys Gly 
                 485                490                495
Ser Ser Thr Tyr Thr Gln Gln Ser His Tyr Ile Leu Thr Leu Ala Asp 
             500                505                510
Leu Ser Ser Thr Asp Tyr Asp Pro Phe Leu Pro Leu Ala Asn Val Lys 
         515                520                525
Ser Ser Glu Pro Val Gln Tyr His Ser Ser Ala Glu Leu Gly Asn Leu 
     530                535                540
Leu Thr Val Glu Glu Glu Lys Lys Arg Arg Ser Leu Glu Leu Ile Pro 
 545                550                555                560
Leu Thr Ala Arg Met Val Met Ala His Leu Val Asn His Leu Gly His 
                 565                570                575
Tyr Pro Leu Ser Gly Gly Pro Ala Ile Leu His Ser Leu Val Ser Glu 
             580                585                590
Asn His Asp Asn Ala His Val Glu Gly Ser Glu Leu Ser Phe Glu Val 
         595                600                605
Phe Arg Ser Pro Asn Leu Gln Leu Phe Val Phe Asn Asp Ser Thr Leu 
     610                615                620
Ile Ser Tyr Leu Gln Thr Pro Thr Glu Gly Pro Val Gly Gly Ser Pro 
 625                630                635                640
Val Gly Ser Leu Ser Asp Val Arg Val Ile Val Arg Asp Ile Ser Gly 
                 645                650                655
Lys Tyr Ser Trp Asp Gly Lys Val Leu Tyr Gly Pro Leu Glu Gly Cys 
             660                665                670
Leu Ala Pro Ser Gly Arg Asn Pro Ser Phe Leu Ile Ser Ser Trp His 
         675                680                685
Arg Asp Thr Phe Gly Pro Gln Lys Asp Ser Ser Gln Val Glu Glu Gly 
     690                695                700
Asp Asp Val Leu Asp Lys Leu Leu Glu Asn Ile Gly His Thr Ser Pro 
 705                710                715                720
Glu Cys Leu Leu Pro Ser Gln Leu Asn Leu Asn Glu Pro Ser Leu Thr 
                 725                730                735
Pro Cys Gly Met Asn Tyr Asp Gln Glu Lys Glu Ile Ile Glu Val Ile 
             740                745                750
Leu Arg Gln Asn Ala Gln Glu Asp Glu Tyr Ile Gln Ser His Asn Phe 
         755                760                765
Asp Ser Ala Met Lys Val Thr Ser Gln Gly Gln Pro Ser Pro Val Glu 
     770                775                780
Pro Arg Gly Pro Phe Tyr Phe Cys Arg Leu Leu Leu Asp Asp Leu Gly 
 785                790                795                800
Met Asn Ser Trp Asp Arg Arg Lys Asn Phe His Leu Leu Lys Lys Asn 
                 805                810                815
Ser Lys Leu Leu Arg Glu Leu Lys Asn Leu Asp Ser Arg Gln Cys Arg 
             820                825                830
Glu Thr His Lys Ile Ala Val Phe Tyr Ile Ala Glu Gly Gln Glu Asp 
         835                840                845
Lys Cys Ser Ile Leu Ser Asn Glu Arg Gly Ser Gln Ala Tyr Glu Asp 
     850                855                860
Phe Val Ala Gly Leu Gly Trp Glu Val Asp Leu Ser Thr His Cys Gly 
 865                870                875                880
Phe Met Gly Gly Leu Gln Arg Asn Gly Ser Thr Gly Gln Thr Ala Pro 
                 885                890                895
Tyr Tyr Ala Thr Ser Thr Val Glu Val Ile Phe His Val Ser Thr Arg 
             900                905                910
Met Pro Ser Asp Ser Asp Asp Ser Leu Thr Lys Lys Leu Arg His Leu 
         915                920                925
Gly Asn Asp Glu Val His Ile Val Trp Ser Glu His Ser Arg Asp Tyr 
     930                935                940
Arg Arg Gly Ile Ile Pro Thr Ala Phe Gly Asp Val Ser Ile Ile Ile 
 945                950                955                960
Tyr Pro Met Lys Asn His Met Phe Phe Ile Ala Ile Thr Lys Lys Pro 
                 965                970                975
Glu Val Pro Phe Phe Gly Pro Leu Phe Asp Gly Ala Ile Val Ser Gly 
             980                985                990
Lys Leu Leu Pro Ser Leu Val Cys Ala Thr Cys Ile Asn Ala Ser Arg 
         995                1000                1005
Ala Val Lys Cys Leu Ile Pro Leu Tyr Gln Ser Pro Arg Val Arg 
     1010                1015                1020



<210> 810
<211> 3344
<212> DNA
<213> Rattus norvegicus
<308> AF041107
<400> 810

gcattatgg  gtagttatt  atngcaccc  ggcttaaaa  ttangttcc  gntngtatg  60
ggggggaat  ggagcggat  acaattcac  cnggaaaca  ttagaccat  attangatt  120
ctaacacct  ggcttttta  ggcaaccat  ttgactgat  agtataaac  agntaaatt  180
catgcatat  aatttattt  taatacaat  aagagagac  agatgtatc  ccaaataga  240
attttttaa  gcatttcta  aatataatg  attgtggat  gcttcatat  gaccaggac  300
tcgtcaata  gatcatcaa  cactgctca  ctcagtttt  ttcacttgg  ttgcctggg  360
ccacaatgc  tattatgga  tttattata  cggctggga  agtggcttc  tcagctttt  420
ttaatgcac  aagagtgga  gcacaggtt  ttctgggat  tttggtttg  ttccccaac  480
tatactgtg  gctgcctgc  ctgcatcca  gcacgcctg  catcgctgt  tctcagttc  540
cagacgtca  ggaacttat  attaaaact  tcttaagct  ggcaagaga  gaaccctct  600
gccctgcac  atgtgtagc  ctttgcagt  taggtatat  gatttgtga  gaattagtc  660
acgaatctc  tcatcctca  attaaagaa  cactgaatg  aatttgtgt  tcattaaag  720
ttactaata  aacagttgc  catgtagct  gtaacatgc  tcacatgct  gttcattat  780
cacctagac  tcagactta  cagcctgac  ctcccttga  aattattca  atcctaata  840
caactatca  acacctttt  ccaagtaca  aagcttcat  atatgaaat  gacaagagg  900
tggttgtgt  attacttct  tgccttctg  actggatca  ggccttacc  ttaaagaca  960
tactccaat  agtccattc  acaggagca  aaaatgaga  gacagaaaa  tctgtcctc  1020
actgtattt  taaggtttt  catgggtgt  tatatggag  acaaagttt  agccatcca  1080
agtactttc  aataagcct  tctgatttg  catctgtag  ttatgaccc  tttatgcat  1140
tggaaagtc  gagagagcc  gaacctcta  actctcctg  ttcagaacg  tcttctaaa  1200
tgcagccgg  gacagaagt  aaaactcag  tgcaacaag  attaatttc  atagcagcc  1260
gtactgtta  tacccatct  gtgaatcac  tgggccatt  tccaatgag  ggtggtcct  1320
ctatgctaa  gagtcaggt  tgtgagaat  atgacaatc  ttatagcga  agtactgaa  1380
tttctcctg  gctctttga  agtccaaat  ttcagttct  tgtgctgaa  aatacaacc  1440
tagtgtctt  tatccagat  agatcagaa  agagtgtgc  tggaggagg  ttagctgct  1500
gccttgtgt  agccaactc  aatgttaga  tcatagtac  tgatctctc  ggaaagtac  1560
catgggatt  tgccatact  tatgggcca  ccattgtaa  tggtttgcc  gaacctaca  1620
ctttcatac  ttcaatgtc  taccaagag  aaccagaag  acctcctac  tctaatgaa  1680
gcttagaag  cataacagt  aaagatgga  tttctctcc  gcttagaag  tttagagaa  1740
ctgttccaa  ttggtctac  ataagagaa  aagaagatg  tcttgatga  ctcctgcag  1800
atttacgca  tacaaatcc  gaatgttta  agagaactg  aatctccct  aatgttcct  1860
ctccacaac  tgtgtgcat  tctgaaaaa  aggagaatg  tgtcattaa  gctatcctt  1920
agcaataca  agaagaaaa  gagtttgta  aaaagcact  taatgactt  aacatgaaa  1980
cctcagaac  agatgaacc  acacctcag  aacctcagt  agcatttta  tactgcaga  2040
tgcttctta  tatattggg  atgaattcc  gggacaaac  gaggagctt  catctcctg  2100
agaaaaatg  aaagctgct  agagaactg  ggaacttgg  ttcaaggca  tgccgagaa  2160
cacacaaga  tgcagtatt  tacgttgct  aaggacaag  agataaata  tccattctc  2220
ccaatatag  aggaagcca  gcatatgaa  attttgttg  tggccttgg  tgggaggta  2280
accttacaa  tcactgtgg  ttcatggga  gactgcaga  gaacaaaag  actggactg  2340
ccactccat  ttttgctac  tctacagta  aagtaatat  tcatgtatc  acaagaatg  2400
cttctgaat  tgatgactc  ctgaccaaa  aattgagac  tctaggaaa  gatgaagta  2460
acattgttt  gtctgaaca  actagagac  acaggagag  aattattcc  acagagttt  2520
gtgatgtcc  cattgtaat  tatccaatg  aaaaccaca  gttcagtat  cagatcatg  2580
aaaagccag  ggttccctt  tttggtccc  tttttgatg  tgctattgt  aatggaaaa  2640
ttctgccca  tatggttcg  tccacagca  taaatgcta  ccgtgctct  aaatcactg  2700
ttccattgt  tcaaaactt  tacgaggag  gagcacggt  cctgcagac  attgtccag  2760
accacttag  gccaacgac  tttgaagac  ttgcagccc  ggttttctc  ccagctccc  2820
accatcatt  ccctgctga  gcaggtaag  ataaaagag  gtgttgatc  cttgtcaca  2880
acccaaaat  caataccct  ttcttctca  tcatggttg  ataaaattc  ggtcattga  2940
atatattat  catgactga  tttggcctg  aaatttcat  gtttccttt  atgtaaatg  3000
ggttgctta  atatccagt  atcctcatc  aagtgcatg  cccatatct  accacagtc  3060
ctggctcct  cttttcatg  gaatctgaa  tatctgcag  aagaactct  aacttcaga  3120
gatcaaatt  tatggccaa  aatacagtg  catcatctc  aantttaca  gtaaagcta  3180
accagtcta  attaaaagc  tttagtaca  caaattatg  tataatatt  aaagacttt  3240
agaaggtac  gcattaata  atttaacta  ttttaagga  atcagcaat  aaaatgctc  3300
tggctcgtg  cgaattcct  cagcccggg  ggatcacta  ttct  3344



<210> 811
<211> 1809
<212> PRT
<213> Rattus norvegicus
<308> P49816
<400> 811

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
  1               5                  10                  15
Ile Leu Leu Gly Leu Gly Thr Ser Arg Pro Asn Pro Arg Cys Ala Glu 
             20                  25                  30
Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
         35                  40                  45
Ser Gly Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
     50                  55                  60
Cys Asp Val Ala Lys Thr Lys Lys Leu Glu Glu His Ala Val Glu Ala 
 65                  70                  75                  80
Leu Trp Lys Ala Val Ser Asp Leu Leu Gln Pro Glu Arg Pro Pro Glu 
                 85                  90                  95
Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
             100                105                110
Gly Asp Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
         115                120                125
Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
     130                135                140
Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
 145                150                155                160
Ala Glu Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                 165                170                175
Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
             180                185                190
Glu Tyr Ile Ala Pro Met Val His Met Ile Cys Leu Leu Cys Ile Arg 
         195                200                205
Thr Val Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
     210                215                220
Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
 225                230                235                240
Ile Thr Leu Cys Arg Thr Val Asn Val Lys Glu Leu Cys Glu Pro Cys 
                 245                250                255
Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
             260                265                270
Ile Tyr Asn Met Cys Arg Ile Met Glu Asn Arg Ser Tyr Met Glu Asp 
         275                280                285
Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
     290                295                300
Gly Ala His Arg Leu Tyr Ser Leu Lys Asn Ser Pro Thr Ser Val Leu 
 305                310                315                320
Pro Ser Phe Tyr Glu Ala Met Thr Cys Pro Asn Glu Val Val Ser Tyr 
                 325                330                335
Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
             340                345                350
Leu Gln Ala Val Thr Trp Asp Ile Leu Leu Asp Ile Ile Glu Arg Leu 
         355                360                365
Leu Gln Gln Leu Gln Asn Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
     370                375                380
His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
 385                390                395                400
His Gly Ser Gln Glu Arg Tyr Tyr Glu Leu Val Glu Ser Tyr Ala Asp 
                 405                410                415
Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Thr Tyr Arg Ala Gln 
             420                425                430
Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Leu Leu 
         435                440                445
Met Glu Arg Phe Phe Arg Asn Glu Cys Arg Ser Ala Val Arg Ile Lys 
     450                455                460
Val Leu Asp Val Leu Ser Phe Val Leu Leu Ile Asn Arg Gln Phe Tyr 
 465                470                475                480
Glu Glu Glu Leu Ile Asn Ser Val Val Ile Ser Gln Leu Ser His Ile 
                 485                490                495
Pro Glu Asp Lys Asp His Gln Val Arg Lys Leu Ala Thr Gln Leu Leu 
             500                505                510
Val Asp Leu Ala Glu Gly Cys His Thr His His Phe Asn Ser Leu Leu 
         515                520                525
Asp Ile Ile Glu Lys Val Met Ala Arg Ser Leu Ser Pro Pro Leu Glu 
     530                535                540
Leu Glu Glu Arg Asp Leu Ala Val Tyr Ser Ala Ser Leu Glu Asp Val 
 545                550                555                560
Lys Thr Ala Val Leu Gly Leu Leu Val Ile Leu Gln Thr Lys Leu Tyr 
                 565                570                575
Thr Leu Pro Ala Ser His Ala Thr Arg Val Tyr Glu Thr Leu Ile Ser 
             580                585                590
His Ile Gln Leu His Tyr Lys His Gly Tyr Ser Leu Pro Ile Ala Ser 
         595                600                605
Ser Ile Arg Leu Gln Ala Phe Asp Phe Leu Leu Leu Leu Arg Ala Asp 
     610                615                620
Ser Leu His Arg Leu Gly Leu Pro Asn Lys Asp Gly Val Val Arg Phe 
 625                630                635                640
Ser Pro Tyr Cys Leu Cys Asp Cys Ala Glu Leu Asp Arg Ala Ser Glu 
                 645                650                655
Lys Lys Ala Ser Gly Pro Leu Ser Pro Pro Thr Gly Pro Pro Ser Pro 
             660                665                670
Val Pro Thr Gly Pro Ala Val Arg Leu Gly His Leu Pro Tyr Ser Leu 
         675                680                685
Leu Phe Arg Val Leu Leu Gln Cys Leu Lys Gln Glu Thr Asp Trp Lys 
     690                695                700
Val Leu Lys Leu Val Leu Ser Lys Leu Pro Glu Ser Leu Arg Tyr Lys 
 705                710                715                720
Val Leu Ile Phe Thr Ser Pro Cys Ser Val Asp Gln Leu Ser Ser Ala 
                 725                730                735
Leu Cys Ser Met Leu Ser Ala Pro Lys Thr Leu Glu Arg Leu Arg Gly 
             740                745                750
Thr Pro Glu Gly Phe Ser Arg Thr Asp Leu His Leu Ala Val Val Pro 
         755                760                765
Val Leu Thr Ala Leu Ile Ser Tyr His Asn Tyr Leu Asp Lys Thr Arg 
     770                775                780
Gln Arg Glu Met Val Tyr Cys Leu Glu Gln Gly Leu Ile Tyr Arg Cys 
 785                790                795                800
Ala Ser Gln Cys Val Val Ala Leu Ala Ile Cys Ser Val Glu Met Pro 
                 805                810                815
Asp Ile Ile Ile Lys Ala Leu Pro Val Leu Val Val Lys Leu Thr His 
             820                825                830
Ile Ser Ala Thr Ala Ser Met Ala Ile Pro Leu Leu Glu Phe Leu Ser 
         835                840                845
Thr Leu Ala Arg Leu Pro His Leu Tyr Arg Asn Phe Ala Ala Glu Gln 
     850                855                860
Tyr Ala Ser Val Phe Ala Ile Ser Leu Pro Tyr Thr Asn Pro Ser Lys 
 865                870                875                880
Phe Asn Gln Tyr Ile Val Cys Leu Ala His His Val Ile Ala Met Trp 
                 885                890                895
Phe Ile Arg Cys Arg Leu Pro Phe Arg Lys Asp Phe Val Pro Tyr Ile 
             900                905                910
Thr Lys Gly Leu Arg Ser Asn Val Leu Leu Ser Phe Asp Asp Thr Pro 
         915                920                925
Glu Lys Asp Lys Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro 
     930                935                940
Lys Ser Leu Arg Ile Ala Arg Ala Pro Lys Gln Gly Leu Asn Asn Ser 
 945                950                955                960
Pro Pro Val Lys Glu Phe Lys Glu Ser Cys Ala Ala Glu Ala Phe Arg 
                 965                970                975
Cys Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
             980                985                990
Thr Ser Leu Thr Ser Ala Ser Leu Gly Ser Ala Asp Glu Asn Ser Met 
         995                1000                1005
Ala Gln Ala Asp Asp Asn Leu Lys Asn Leu His Leu Glu Leu Thr Glu 
     1010                1015                1020
Thr Cys Leu Asp Met Met Ala Arg Tyr Val Phe Ser Asn Phe Thr Ala 
 1025                1030                1035                1040
Val Pro Lys Arg Ser Pro Val Gly Glu Phe Leu Leu Ala Gly Gly Arg 
                 1045                1050                1055
Thr Lys Thr Trp Leu Val Gly Asn Lys Leu Val Thr Val Thr Thr Ser 
             1060                1065                1070
Val Gly Thr Gly Thr Arg Ser Leu Leu Gly Leu Asp Ser Gly Asp Leu 
         1075                1080                1085
Gln Gly Gly Ser Ala Ser Ser Ser Asp Pro Gly Thr His Val Arg Gln 
     1090                1095                1100
Thr Lys Glu Ala Pro Ala Lys Leu Glu Ser Gln Ala Gly Gln Gln Val 
 1105                1110                1115                1120
Ser Arg Gly Ala Arg Asp Arg Val Arg Ser Met Ser Gly Gly His Gly 
                 1125                1130                1135
Leu Arg Val Gly Val Leu Asp Thr Ser Ala Pro Tyr Thr Pro Gly Gly 
             1140                1145                1150
Pro Ala Ser Leu Gly Ala Gln Ala Ala Pro Ala Ala Arg Pro Glu Lys 
         1155                1160                1165
Pro Cys Ala Gly Ala Gln Leu Pro Ala Ala Glu Lys Ala Asn Leu Ala 
     1170                1175                1180
Ala Tyr Val Pro Leu Leu Thr Gln Gly Trp Ala Glu Ile Leu Val Arg 
 1185                1190                1195                1200
Arg Pro Thr Gly Asn Thr Ser Trp Leu Met Ser Leu Glu Asn Pro Leu 
                 1205                1210                1215
Ser Pro Phe Ser Ser Asp Ile Asn Asn Met Pro Leu Gln Glu Leu Ser 
             1220                1225                1230
Asn Ala Leu Met Ala Ala Glu Arg Phe Lys Glu His Arg Asp Thr Ala 
         1235                1240                1245
Leu Tyr Lys Ser Leu Ser Val Pro Ala Ala Gly Thr Ala Lys Pro Pro 
     1250                1255                1260
Thr Leu Pro Arg Ser Asn Thr Val Ala Ser Phe Ser Ser Leu Tyr Gln 
 1265                1270                1275                1280
Pro Ser Cys Gln Gly Gln Leu His Arg Ser Val Ser Trp Ala Asp Ser 
                 1285                1290                1295
Ala Val Val Leu Glu Glu Gly Ser Pro Gly Glu Ala His Val Pro Val 
             1300                1305                1310
Glu Pro Pro Glu Leu Glu Asp Phe Glu Ala Ala Leu Gly Thr Asp Arg 
         1315                1320                1325
His Cys Gln Arg Pro Asp Ala Tyr Ser Arg Ser Ser Ser Ala Ser Ser 
     1330                1335                1340
Gln Glu Glu Lys Ser His Leu Glu Glu Leu Ala Ala Gly Gly Ile Pro 
 1345                1350                1355                1360
Ile Glu Arg Ala Ile Ser Ser Glu Gly Ala Arg Pro Thr Val Asp Leu 
                 1365                1370                1375
Ser Phe Gln Pro Ser Gln Pro Leu Ser Lys Ser Ser Ser Ser Pro Glu 
             1380                1385                1390
Leu Gln Thr Leu Gln Asp Ile Leu Gly Asp Leu Gly Asp Lys Thr Asp 
         1395                1400                1405
Ile Gly Arg Leu Ser Pro Glu Ala Lys Val Arg Ser Gln Ser Gly Ile 
     1410                1415                1420
Leu Asp Gly Glu Ala Ala Thr Trp Ser Ala Pro Gly Glu Glu Ser Arg 
 1425                1430                1435                1440
Ile Thr Val Pro Pro Glu Gly Pro Leu Pro Ser Ser Ser Pro Arg Ser 
                 1445                1450                1455
Pro Ser Gly Leu Arg Pro Arg Gly Tyr Thr Ile Ser Asp Ser Ala Pro 
             1460                1465                1470
Ser Arg Arg Gly Lys Arg Val Glu Arg Asp Asn Phe Lys Ser Arg Thr 
         1475                1480                1485
Ala Ala Ser Ser Ala Glu Lys Val Pro Gly Ile Asn Pro Ser Phe Val 
     1490                1495                1500
Phe Leu Gln Leu Tyr His Ser Pro Phe Cys Gly Asp Glu Ser Asn Lys 
 1505                1510                1515                1520
Pro Ile Leu Leu Pro Asn Glu Ser Phe Glu Arg Ser Val Gln Leu Leu 
                 1525                1530                1535
Asp Gln Ile Pro Ser Tyr Asp Thr His Lys Ile Ala Val Leu Tyr Val 
             1540                1545                1550
Gly Glu Gly Gln Ser Ser Ser Glu Leu Ala Ile Leu Ser Asn Glu His 
         1555                1560                1565
Gly Ser Tyr Arg Tyr Thr Glu Phe Leu Thr Gly Leu Gly Arg Leu Ile 
     1570                1575                1580
Glu Leu Lys Asp Cys Gln Pro Asp Lys Val Tyr Leu Gly Gly Leu Asp 
 1585                1590                1595                1600
Val Cys Gly Glu Asp Gly Gln Phe Thr Tyr Cys Trp His Asp Asp Ile 
                 1605                1610                1615
Met Gln Ala Val Phe His Ile Ala Thr Leu Met Pro Thr Lys Asp Val 
             1620                1625                1630
Asp Lys His Arg Cys Asp Lys Lys Arg His Leu Gly Asn Asp Phe Val 
         1635                1640                1645
Ser Ile Ile Tyr Asn Asp Ser Gly Glu Asp Phe Lys Leu Gly Thr Ile 
     1650                1655                1660
Lys Gly Gln Phe Asn Phe Val His Val Ile Ile Thr Pro Leu Asp Tyr 
 1665                1670                1675                1680
Lys Cys Asn Leu Leu Thr Leu Gln Cys Arg Lys Asp Met Glu Gly Leu 
                 1685                1690                1695
Val Asp Thr Ser Val Ala Lys Ile Val Ser Asp Arg Asn Leu Ser Phe 
             1700                1705                1710
Val Ala Arg Gln Met Ala Leu His Ala Asn Met Ala Ser Gln Val His 
         1715                1720                1725
His Arg Arg Ser Asn Pro Thr Asp Ile Tyr Pro Ser Lys Trp Ile Ala 
     1730                1735                1740
Arg Leu Arg His Ile Lys Arg Leu Arg Gln Arg Ile Arg Glu Glu Val 
 1745                1750                1755                1760
His Tyr Ser Asn Pro Ser Leu Pro Leu Met His Pro Pro Ala His Thr 
                 1765                1770                1775
Lys Val Pro Ala Gln Ala Pro Thr Glu Ala Thr Pro Thr Tyr Glu Thr 
             1780                1785                1790
Gly Gln Arg Lys Arg Leu Ile Ser Ser Val Asp Asp Phe Thr Glu Phe 
         1795                1800                1805
Val 
     1810



<210> 812
<211> 2121
<212> DNA
<213> Homo sapiens
<308> AL050050
<400> 812

aaagatgga  tttccagtt  aaaagattt  gagaaactg  accaacttg  gatacaata  60
gagatgaag  agatgctct  gatgaactc  tgcagtatt  gggtgttac  agtcctgaa  120
gcttacaga  aactggaat  tcacttaat  ttcctgctc  acaacctgt  tgcatttct  180
aaaaacaag  aagtgatgt  attaatgct  tccttaagc  acatacaga  gaaaaagaa  240
ttgttgaga  gcactttaa  gacttaaac  tgaaagctg  ggaacaaga  gaaccaata  300
ctcaaaaac  tcagtcagc  ttttattat  gcagattgc  tcttagtat  ttgggaatg  360
attcctggg  caaacggag  agctttcat  tcctgaaga  aaatgaaaa  ctacttaga  420
aacttagga  cttggattc  aggcagtgc  gagagacac  caagattgc  gtattttat  480
ttgctgaag  acaagaaga  aaacactcc  ttctcacca  tacaggagg  agtcaagca  540
atgaagatt  tgtagctgg  cttggttgg  aggtaaatc  tacaaacca  tgtggtttt  600
tgggaggac  acaaaaaaa  aaaagcact  gattgacca  tccatattt  gctacctct  660
cagtagaag  aatatttca  atgtcaaca  gaatgcctt  tgattctga  gattctttg  720
ccaaaaaat  gagacattt  ggaaatgat  aagtgcaca  tgtttggtc  gagcatact  780
gagactaca  gagaggaat  attcccaca  aatttggtg  tgtccttat  gtaatatat  840
caatgaaaa  tcacatgtt  agtattcag  taatgagaa  accagaggt  cccttcttt  900
gtccccttt  tgatggtgc  attgtgaat  gaaaggttc  acccattat  gttagagca  960
cagctataa  tgcaagccg  gctctgaaa  ctctgattc  attgtatca  aacttctat  1020
aggagagag  acgatacct  caaacaatt  tccagcacc  cttagaacc  acaacattt  1080
aagattttg  agcacaggt  ttttctcca  ctccctacc  ccatttacc  tctggtgcc  1140
atcattaaa  atcagttct  tttatctga  ggctcctac  cagagattc  acccagtga  1200
actcccaca  cagcgcagg  agatggggc  gacctggcc  ctccaatgt  tcctcgaac  1260
agcaaaagc  gcatgtcca  gaagctgcg  cgttcctct  gctcagcca  taaatccta  1320
ggagacaag  agcccagca  tgatcagca  tagccacct  agcatggac  tagggttaa  1380
cctttcagg  cttcatgtc  gccataaca  gcatgtttc  tcctgtaca  ttatttgag  1440
aaacactgg  tttaaataa  tttaaataa  ttgtagctt  atattaaag  tttaagtta  1500
ttattgttt  atttttttc  cacaatcca  gctgccata  tttgagggc  gggggagtt  1560
tattctaca  cctttacct  cctagataa  tatgtctaa  tagttttat  tttaatttc  1620
tggttaact  tgagccaaa  tacaattgg  caattagtc  cattattta  tgtgctcca  1680
tgcaacttt  tggttcaat  aatatataa  tttttacaa  tgtaaaatt  tacatttaa  1740
catttgtaa  gttacagca  aagatgtac  tgttaatac  cagaatgtg  acagattat  1800
tgttatgac  ataaaacac  caaaataaa  ggtctttag  atctcaaat  ccaactgaa  1860
tcattttag  attaactct  cttcccaaa  caatgtctc  tttcttggc  gtgcaggtg  1920
tgccatgtt  tatccaata  ctagaaaaa  cactgtgct  aacttttat  tttagcttc  1980
aagtatttt  ctaatgttt  gcatttcaa  tggtatcac  gttaaatgc  atttgtttt  2040
agattgtgg  cttttatta  tggctgcta  atcctggtg  ttctatgtt  ttttttaag  2100
accaaaaaa  aaaaaaaaa  a  2121



<210> 813
<211> 3344
<212> DNA
<213> Rattus norvegicus
<308> AF041107
<400> 813

gcattatgg  gtagttatt  atngcaccc  ggcttaaaa  ttangttcc  gntngtatg  60
ggggggaat  ggagcggat  acaattcac  cnggaaaca  ttagaccat  attangatt  120
ctaacacct  ggcttttta  ggcaaccat  ttgactgat  agtataaac  agntaaatt  180
catgcatat  aatttattt  taatacaat  aagagagac  agatgtatc  ccaaataga  240
attttttaa  gcatttcta  aatataatg  attgtggat  gcttcatat  gaccaggac  300
tcgtcaata  gatcatcaa  cactgctca  ctcagtttt  ttcacttgg  ttgcctggg  360
ccacaatgc  tattatgga  tttattata  cggctggga  agtggcttc  tcagctttt  420
ttaatgcac  aagagtgga  gcacaggtt  ttctgggat  tttggtttg  ttccccaac  480
tatactgtg  gctgcctgc  ctgcatcca  gcacgcctg  catcgctgt  tctcagttc  540
cagacgtca  ggaacttat  attaaaact  tcttaagct  ggcaagaga  gaaccctct  600
gccctgcac  atgtgtagc  ctttgcagt  taggtatat  gatttgtga  gaattagtc  660
acgaatctc  tcatcctca  attaaagaa  cactgaatg  aatttgtgt  tcattaaag  720
ttactaata  aacagttgc  catgtagct  gtaacatgc  tcacatgct  gttcattat  780
cacctagac  tcagactta  cagcctgac  ctcccttga  aattattca  atcctaata  840
caactatca  acacctttt  ccaagtaca  aagcttcat  atatgaaat  gacaagagg  900
tggttgtgt  attacttct  tgccttctg  actggatca  ggccttacc  ttaaagaca  960
tactccaat  agtccattc  acaggagca  aaaatgaga  gacagaaaa  tctgtcctc  1020
actgtattt  taaggtttt  catgggtgt  tatatggag  acaaagttt  agccatcca  1080
agtactttc  aataagcct  tctgatttg  catctgtag  ttatgaccc  tttatgcat  1140
tggaaagtc  gagagagcc  gaacctcta  actctcctg  ttcagaacg  tcttctaaa  1200
tgcagccgg  gacagaagt  aaaactcag  tgcaacaag  attaatttc  atagcagcc  1260
gtactgtta  tacccatct  gtgaatcac  tgggccatt  tccaatgag  ggtggtcct  1320
ctatgctaa  gagtcaggt  tgtgagaat  atgacaatc  ttatagcga  agtactgaa  1380
tttctcctg  gctctttga  agtccaaat  ttcagttct  tgtgctgaa  aatacaacc  1440
tagtgtctt  tatccagat  agatcagaa  agagtgtgc  tggaggagg  ttagctgct  1500
gccttgtgt  agccaactc  aatgttaga  tcatagtac  tgatctctc  ggaaagtac  1560
catgggatt  tgccatact  tatgggcca  ccattgtaa  tggtttgcc  gaacctaca  1620
ctttcatac  ttcaatgtc  taccaagag  aaccagaag  acctcctac  tctaatgaa  1680
gcttagaag  cataacagt  aaagatgga  tttctctcc  gcttagaag  tttagagaa  1740
ctgttccaa  ttggtctac  ataagagaa  aagaagatg  tcttgatga  ctcctgcag  1800
atttacgca  tacaaatcc  gaatgttta  agagaactg  aatctccct  aatgttcct  1860
ctccacaac  tgtgtgcat  tctgaaaaa  aggagaatg  tgtcattaa  gctatcctt  1920
agcaataca  agaagaaaa  gagtttgta  aaaagcact  taatgactt  aacatgaaa  1980
cctcagaac  agatgaacc  acacctcag  aacctcagt  agcatttta  tactgcaga  2040
tgcttctta  tatattggg  atgaattcc  gggacaaac  gaggagctt  catctcctg  2100
agaaaaatg  aaagctgct  agagaactg  ggaacttgg  ttcaaggca  tgccgagaa  2160
cacacaaga  tgcagtatt  tacgttgct  aaggacaag  agataaata  tccattctc  2220
ccaatatag  aggaagcca  gcatatgaa  attttgttg  tggccttgg  tgggaggta  2280
accttacaa  tcactgtgg  ttcatggga  gactgcaga  gaacaaaag  actggactg  2340
ccactccat  ttttgctac  tctacagta  aagtaatat  tcatgtatc  acaagaatg  2400
cttctgaat  tgatgactc  ctgaccaaa  aattgagac  tctaggaaa  gatgaagta  2460
acattgttt  gtctgaaca  actagagac  acaggagag  aattattcc  acagagttt  2520
gtgatgtcc  cattgtaat  tatccaatg  aaaaccaca  gttcagtat  cagatcatg  2580
aaaagccag  ggttccctt  tttggtccc  tttttgatg  tgctattgt  aatggaaaa  2640
ttctgccca  tatggttcg  tccacagca  taaatgcta  ccgtgctct  aaatcactg  2700
ttccattgt  tcaaaactt  tacgaggag  gagcacggt  cctgcagac  attgtccag  2760
accacttag  gccaacgac  tttgaagac  ttgcagccc  ggttttctc  ccagctccc  2820
accatcatt  ccctgctga  gcaggtaag  ataaaagag  gtgttgatc  cttgtcaca  2880
acccaaaat  caataccct  ttcttctca  tcatggttg  ataaaattc  ggtcattga  2940
atatattat  catgactga  tttggcctg  aaatttcat  gtttccttt  atgtaaatg  3000
ggttgctta  atatccagt  atcctcatc  aagtgcatg  cccatatct  accacagtc  3060
ctggctcct  cttttcatg  gaatctgaa  tatctgcag  aagaactct  aacttcaga  3120
gatcaaatt  tatggccaa  aatacagtg  catcatctc  aantttaca  gtaaagcta  3180
accagtcta  attaaaagc  tttagtaca  caaattatg  tataatatt  aaagacttt  3240
agaaggtac  gcattaata  atttaacta  ttttaagga  atcagcaat  aaaatgctc  3300
tggctcgtg  cgaattcct  cagcccggg  ggatcacta  ttct  3344



<210> 814
<211> 1809
<212> PRT
<213> Rattus norvegicus
<308> P49816
<400> 814

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
  1               5                  10                  15
Ile Leu Leu Gly Leu Gly Thr Ser Arg Pro Asn Pro Arg Cys Ala Glu 
             20                  25                  30
Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
         35                  40                  45
Ser Gly Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
     50                  55                  60
Cys Asp Val Ala Lys Thr Lys Lys Leu Glu Glu His Ala Val Glu Ala 
 65                  70                  75                  80
Leu Trp Lys Ala Val Ser Asp Leu Leu Gln Pro Glu Arg Pro Pro Glu 
                 85                  90                  95
Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
             100                105                110
Gly Asp Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
         115                120                125
Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
     130                135                140
Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
 145                150                155                160
Ala Glu Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                 165                170                175
Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
             180                185                190
Glu Tyr Ile Ala Pro Met Val His Met Ile Cys Leu Leu Cys Ile Arg 
         195                200                205
Thr Val Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
     210                215                220
Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
 225                230                235                240
Ile Thr Leu Cys Arg Thr Val Asn Val Lys Glu Leu Cys Glu Pro Cys 
                 245                250                255
Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
             260                265                270
Ile Tyr Asn Met Cys Arg Ile Met Glu Asn Arg Ser Tyr Met Glu Asp 
         275                280                285
Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
     290                295                300
Gly Ala His Arg Leu Tyr Ser Leu Lys Asn Ser Pro Thr Ser Val Leu 
 305                310                315                320
Pro Ser Phe Tyr Glu Ala Met Thr Cys Pro Asn Glu Val Val Ser Tyr 
                 325                330                335
Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
             340                345                350
Leu Gln Ala Val Thr Trp Asp Ile Leu Leu Asp Ile Ile Glu Arg Leu 
         355                360                365
Leu Gln Gln Leu Gln Asn Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
     370                375                380
His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
 385                390                395                400
His Gly Ser Gln Glu Arg Tyr Tyr Glu Leu Val Glu Ser Tyr Ala Asp 
                 405                410                415
Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Thr Tyr Arg Ala Gln 
             420                425                430
Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Leu Leu 
         435                440                445
Met Glu Arg Phe Phe Arg Asn Glu Cys Arg Ser Ala Val Arg Ile Lys 
     450                455                460
Val Leu Asp Val Leu Ser Phe Val Leu Leu Ile Asn Arg Gln Phe Tyr 
 465                470                475                480
Glu Glu Glu Leu Ile Asn Ser Val Val Ile Ser Gln Leu Ser His Ile 
                 485                490                495
Pro Glu Asp Lys Asp His Gln Val Arg Lys Leu Ala Thr Gln Leu Leu 
             500                505                510
Val Asp Leu Ala Glu Gly Cys His Thr His His Phe Asn Ser Leu Leu 
         515                520                525
Asp Ile Ile Glu Lys Val Met Ala Arg Ser Leu Ser Pro Pro Leu Glu 
     530                535                540
Leu Glu Glu Arg Asp Leu Ala Val Tyr Ser Ala Ser Leu Glu Asp Val 
 545                550                555                560
Lys Thr Ala Val Leu Gly Leu Leu Val Ile Leu Gln Thr Lys Leu Tyr 
                 565                570                575
Thr Leu Pro Ala Ser His Ala Thr Arg Val Tyr Glu Thr Leu Ile Ser 
             580                585                590
His Ile Gln Leu His Tyr Lys His Gly Tyr Ser Leu Pro Ile Ala Ser 
         595                600                605
Ser Ile Arg Leu Gln Ala Phe Asp Phe Leu Leu Leu Leu Arg Ala Asp 
     610                615                620
Ser Leu His Arg Leu Gly Leu Pro Asn Lys Asp Gly Val Val Arg Phe 
 625                630                635                640
Ser Pro Tyr Cys Leu Cys Asp Cys Ala Glu Leu Asp Arg Ala Ser Glu 
                 645                650                655
Lys Lys Ala Ser Gly Pro Leu Ser Pro Pro Thr Gly Pro Pro Ser Pro 
             660                665                670
Val Pro Thr Gly Pro Ala Val Arg Leu Gly His Leu Pro Tyr Ser Leu 
         675                680                685
Leu Phe Arg Val Leu Leu Gln Cys Leu Lys Gln Glu Thr Asp Trp Lys 
     690                695                700
Val Leu Lys Leu Val Leu Ser Lys Leu Pro Glu Ser Leu Arg Tyr Lys 
 705                710                715                720
Val Leu Ile Phe Thr Ser Pro Cys Ser Val Asp Gln Leu Ser Ser Ala 
                 725                730                735
Leu Cys Ser Met Leu Ser Ala Pro Lys Thr Leu Glu Arg Leu Arg Gly 
             740                745                750
Thr Pro Glu Gly Phe Ser Arg Thr Asp Leu His Leu Ala Val Val Pro 
         755                760                765
Val Leu Thr Ala Leu Ile Ser Tyr His Asn Tyr Leu Asp Lys Thr Arg 
     770                775                780
Gln Arg Glu Met Val Tyr Cys Leu Glu Gln Gly Leu Ile Tyr Arg Cys 
 785                790                795                800
Ala Ser Gln Cys Val Val Ala Leu Ala Ile Cys Ser Val Glu Met Pro 
                 805                810                815
Asp Ile Ile Ile Lys Ala Leu Pro Val Leu Val Val Lys Leu Thr His 
             820                825                830
Ile Ser Ala Thr Ala Ser Met Ala Ile Pro Leu Leu Glu Phe Leu Ser 
         835                840                845
Thr Leu Ala Arg Leu Pro His Leu Tyr Arg Asn Phe Ala Ala Glu Gln 
     850                855                860
Tyr Ala Ser Val Phe Ala Ile Ser Leu Pro Tyr Thr Asn Pro Ser Lys 
 865                870                875                880
Phe Asn Gln Tyr Ile Val Cys Leu Ala His His Val Ile Ala Met Trp 
                 885                890                895
Phe Ile Arg Cys Arg Leu Pro Phe Arg Lys Asp Phe Val Pro Tyr Ile 
             900                905                910
Thr Lys Gly Leu Arg Ser Asn Val Leu Leu Ser Phe Asp Asp Thr Pro 
         915                920                925
Glu Lys Asp Lys Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro 
     930                935                940
Lys Ser Leu Arg Ile Ala Arg Ala Pro Lys Gln Gly Leu Asn Asn Ser 
 945                950                955                960
Pro Pro Val Lys Glu Phe Lys Glu Ser Cys Ala Ala Glu Ala Phe Arg 
                 965                970                975
Cys Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
             980                985                990
Thr Ser Leu Thr Ser Ala Ser Leu Gly Ser Ala Asp Glu Asn Ser Met 
         995                1000                1005
Ala Gln Ala Asp Asp Asn Leu Lys Asn Leu His Leu Glu Leu Thr Glu 
     1010                1015                1020
Thr Cys Leu Asp Met Met Ala Arg Tyr Val Phe Ser Asn Phe Thr Ala 
 1025                1030                1035                1040
Val Pro Lys Arg Ser Pro Val Gly Glu Phe Leu Leu Ala Gly Gly Arg 
                 1045                1050                1055
Thr Lys Thr Trp Leu Val Gly Asn Lys Leu Val Thr Val Thr Thr Ser 
             1060                1065                1070
Val Gly Thr Gly Thr Arg Ser Leu Leu Gly Leu Asp Ser Gly Asp Leu 
         1075                1080                1085
Gln Gly Gly Ser Ala Ser Ser Ser Asp Pro Gly Thr His Val Arg Gln 
     1090                1095                1100
Thr Lys Glu Ala Pro Ala Lys Leu Glu Ser Gln Ala Gly Gln Gln Val 
 1105                1110                1115                1120
Ser Arg Gly Ala Arg Asp Arg Val Arg Ser Met Ser Gly Gly His Gly 
                 1125                1130                1135
Leu Arg Val Gly Val Leu Asp Thr Ser Ala Pro Tyr Thr Pro Gly Gly 
             1140                1145                1150
Pro Ala Ser Leu Gly Ala Gln Ala Ala Pro Ala Ala Arg Pro Glu Lys 
         1155                1160                1165
Pro Cys Ala Gly Ala Gln Leu Pro Ala Ala Glu Lys Ala Asn Leu Ala 
     1170                1175                1180
Ala Tyr Val Pro Leu Leu Thr Gln Gly Trp Ala Glu Ile Leu Val Arg 
 1185                1190                1195                1200
Arg Pro Thr Gly Asn Thr Ser Trp Leu Met Ser Leu Glu Asn Pro Leu 
                 1205                1210                1215
Ser Pro Phe Ser Ser Asp Ile Asn Asn Met Pro Leu Gln Glu Leu Ser 
             1220                1225                1230
Asn Ala Leu Met Ala Ala Glu Arg Phe Lys Glu His Arg Asp Thr Ala 
         1235                1240                1245
Leu Tyr Lys Ser Leu Ser Val Pro Ala Ala Gly Thr Ala Lys Pro Pro 
     1250                1255                1260
Thr Leu Pro Arg Ser Asn Thr Val Ala Ser Phe Ser Ser Leu Tyr Gln 
 1265                1270                1275                1280
Pro Ser Cys Gln Gly Gln Leu His Arg Ser Val Ser Trp Ala Asp Ser 
                 1285                1290                1295
Ala Val Val Leu Glu Glu Gly Ser Pro Gly Glu Ala His Val Pro Val 
             1300                1305                1310
Glu Pro Pro Glu Leu Glu Asp Phe Glu Ala Ala Leu Gly Thr Asp Arg 
         1315                1320                1325
His Cys Gln Arg Pro Asp Ala Tyr Ser Arg Ser Ser Ser Ala Ser Ser 
     1330                1335                1340
Gln Glu Glu Lys Ser His Leu Glu Glu Leu Ala Ala Gly Gly Ile Pro 
 1345                1350                1355                1360
Ile Glu Arg Ala Ile Ser Ser Glu Gly Ala Arg Pro Thr Val Asp Leu 
                 1365                1370                1375
Ser Phe Gln Pro Ser Gln Pro Leu Ser Lys Ser Ser Ser Ser Pro Glu 
             1380                1385                1390
Leu Gln Thr Leu Gln Asp Ile Leu Gly Asp Leu Gly Asp Lys Thr Asp 
         1395                1400                1405
Ile Gly Arg Leu Ser Pro Glu Ala Lys Val Arg Ser Gln Ser Gly Ile 
     1410                1415                1420
Leu Asp Gly Glu Ala Ala Thr Trp Ser Ala Pro Gly Glu Glu Ser Arg 
 1425                1430                1435                1440
Ile Thr Val Pro Pro Glu Gly Pro Leu Pro Ser Ser Ser Pro Arg Ser 
                 1445                1450                1455
Pro Ser Gly Leu Arg Pro Arg Gly Tyr Thr Ile Ser Asp Ser Ala Pro 
             1460                1465                1470
Ser Arg Arg Gly Lys Arg Val Glu Arg Asp Asn Phe Lys Ser Arg Thr 
         1475                1480                1485
Ala Ala Ser Ser Ala Glu Lys Val Pro Gly Ile Asn Pro Ser Phe Val 
     1490                1495                1500
Phe Leu Gln Leu Tyr His Ser Pro Phe Cys Gly Asp Glu Ser Asn Lys 
 1505                1510                1515                1520
Pro Ile Leu Leu Pro Asn Glu Ser Phe Glu Arg Ser Val Gln Leu Leu 
                 1525                1530                1535
Asp Gln Ile Pro Ser Tyr Asp Thr His Lys Ile Ala Val Leu Tyr Val 
             1540                1545                1550
Gly Glu Gly Gln Ser Ser Ser Glu Leu Ala Ile Leu Ser Asn Glu His 
         1555                1560                1565
Gly Ser Tyr Arg Tyr Thr Glu Phe Leu Thr Gly Leu Gly Arg Leu Ile 
     1570                1575                1580
Glu Leu Lys Asp Cys Gln Pro Asp Lys Val Tyr Leu Gly Gly Leu Asp 
 1585                1590                1595                1600
Val Cys Gly Glu Asp Gly Gln Phe Thr Tyr Cys Trp His Asp Asp Ile 
                 1605                1610                1615
Met Gln Ala Val Phe His Ile Ala Thr Leu Met Pro Thr Lys Asp Val 
             1620                1625                1630
Asp Lys His Arg Cys Asp Lys Lys Arg His Leu Gly Asn Asp Phe Val 
         1635                1640                1645
Ser Ile Ile Tyr Asn Asp Ser Gly Glu Asp Phe Lys Leu Gly Thr Ile 
     1650                1655                1660
Lys Gly Gln Phe Asn Phe Val His Val Ile Ile Thr Pro Leu Asp Tyr 
 1665                1670                1675                1680
Lys Cys Asn Leu Leu Thr Leu Gln Cys Arg Lys Asp Met Glu Gly Leu 
                 1685                1690                1695
Val Asp Thr Ser Val Ala Lys Ile Val Ser Asp Arg Asn Leu Ser Phe 
             1700                1705                1710
Val Ala Arg Gln Met Ala Leu His Ala Asn Met Ala Ser Gln Val His 
         1715                1720                1725
His Arg Arg Ser Asn Pro Thr Asp Ile Tyr Pro Ser Lys Trp Ile Ala 
     1730                1735                1740
Arg Leu Arg His Ile Lys Arg Leu Arg Gln Arg Ile Arg Glu Glu Val 
 1745                1750                1755                1760
His Tyr Ser Asn Pro Ser Leu Pro Leu Met His Pro Pro Ala His Thr 
                 1765                1770                1775
Lys Val Pro Ala Gln Ala Pro Thr Glu Ala Thr Pro Thr Tyr Glu Thr 
             1780                1785                1790
Gly Gln Arg Lys Arg Leu Ile Ser Ser Val Asp Asp Phe Thr Glu Phe 
         1795                1800                1805
Val 
     1810



<210> 815
<211> 2121
<212> DNA
<213> Homo sapiens
<308> AL050050
<400> 815

aaagatgga  tttccagtt  aaaagattt  gagaaactg  accaacttg  gatacaata  60
gagatgaag  agatgctct  gatgaactc  tgcagtatt  gggtgttac  agtcctgaa  120
gcttacaga  aactggaat  tcacttaat  ttcctgctc  acaacctgt  tgcatttct  180
aaaaacaag  aagtgatgt  attaatgct  tccttaagc  acatacaga  gaaaaagaa  240
ttgttgaga  gcactttaa  gacttaaac  tgaaagctg  ggaacaaga  gaaccaata  300
ctcaaaaac  tcagtcagc  ttttattat  gcagattgc  tcttagtat  ttgggaatg  360
attcctggg  caaacggag  agctttcat  tcctgaaga  aaatgaaaa  ctacttaga  420
aacttagga  cttggattc  aggcagtgc  gagagacac  caagattgc  gtattttat  480
ttgctgaag  acaagaaga  aaacactcc  ttctcacca  tacaggagg  agtcaagca  540
atgaagatt  tgtagctgg  cttggttgg  aggtaaatc  tacaaacca  tgtggtttt  600
tgggaggac  acaaaaaaa  aaaagcact  gattgacca  tccatattt  gctacctct  660
cagtagaag  aatatttca  atgtcaaca  gaatgcctt  tgattctga  gattctttg  720
ccaaaaaat  gagacattt  ggaaatgat  aagtgcaca  tgtttggtc  gagcatact  780
gagactaca  gagaggaat  attcccaca  aatttggtg  tgtccttat  gtaatatat  840
caatgaaaa  tcacatgtt  agtattcag  taatgagaa  accagaggt  cccttcttt  900
gtccccttt  tgatggtgc  attgtgaat  gaaaggttc  acccattat  gttagagca  960
cagctataa  tgcaagccg  gctctgaaa  ctctgattc  attgtatca  aacttctat  1020
aggagagag  acgatacct  caaacaatt  tccagcacc  cttagaacc  acaacattt  1080
aagattttg  agcacaggt  ttttctcca  ctccctacc  ccatttacc  tctggtgcc  1140
atcattaaa  atcagttct  tttatctga  ggctcctac  cagagattc  acccagtga  1200
actcccaca  cagcgcagg  agatggggc  gacctggcc  ctccaatgt  tcctcgaac  1260
agcaaaagc  gcatgtcca  gaagctgcg  cgttcctct  gctcagcca  taaatccta  1320
ggagacaag  agcccagca  tgatcagca  tagccacct  agcatggac  tagggttaa  1380
cctttcagg  cttcatgtc  gccataaca  gcatgtttc  tcctgtaca  ttatttgag  1440
aaacactgg  tttaaataa  tttaaataa  ttgtagctt  atattaaag  tttaagtta  1500
ttattgttt  atttttttc  cacaatcca  gctgccata  tttgagggc  gggggagtt  1560
tattctaca  cctttacct  cctagataa  tatgtctaa  tagttttat  tttaatttc  1620
tggttaact  tgagccaaa  tacaattgg  caattagtc  cattattta  tgtgctcca  1680
tgcaacttt  tggttcaat  aatatataa  tttttacaa  tgtaaaatt  tacatttaa  1740
catttgtaa  gttacagca  aagatgtac  tgttaatac  cagaatgtg  acagattat  1800
tgttatgac  ataaaacac  caaaataaa  ggtctttag  atctcaaat  ccaactgaa  1860
tcattttag  attaactct  cttcccaaa  caatgtctc  tttcttggc  gtgcaggtg  1920
tgccatgtt  tatccaata  ctagaaaaa  cactgtgct  aacttttat  tttagcttc  1980
aagtatttt  ctaatgttt  gcatttcaa  tggtatcac  gttaaatgc  atttgtttt  2040
agattgtgg  cttttatta  tggctgcta  atcctggtg  ttctatgtt  ttttttaag  2100
accaaaaaa  aaaaaaaaa  a  2121



<210> 816
<211> 3344
<212> DNA
<213> Rattus norvegicus
<308> AF041107
<400> 816

gcattatgg  gtagttatt  atngcaccc  ggcttaaaa  ttangttcc  gntngtatg  60
ggggggaat  ggagcggat  acaattcac  cnggaaaca  ttagaccat  attangatt  120
ctaacacct  ggcttttta  ggcaaccat  ttgactgat  agtataaac  agntaaatt  180
catgcatat  aatttattt  taatacaat  aagagagac  agatgtatc  ccaaataga  240
attttttaa  gcatttcta  aatataatg  attgtggat  gcttcatat  gaccaggac  300
tcgtcaata  gatcatcaa  cactgctca  ctcagtttt  ttcacttgg  ttgcctggg  360
ccacaatgc  tattatgga  tttattata  cggctggga  agtggcttc  tcagctttt  420
ttaatgcac  aagagtgga  gcacaggtt  ttctgggat  tttggtttg  ttccccaac  480
tatactgtg  gctgcctgc  ctgcatcca  gcacgcctg  catcgctgt  tctcagttc  540
cagacgtca  ggaacttat  attaaaact  tcttaagct  ggcaagaga  gaaccctct  600
gccctgcac  atgtgtagc  ctttgcagt  taggtatat  gatttgtga  gaattagtc  660
acgaatctc  tcatcctca  attaaagaa  cactgaatg  aatttgtgt  tcattaaag  720
ttactaata  aacagttgc  catgtagct  gtaacatgc  tcacatgct  gttcattat  780
cacctagac  tcagactta  cagcctgac  ctcccttga  aattattca  atcctaata  840
caactatca  acacctttt  ccaagtaca  aagcttcat  atatgaaat  gacaagagg  900
tggttgtgt  attacttct  tgccttctg  actggatca  ggccttacc  ttaaagaca  960
tactccaat  agtccattc  acaggagca  aaaatgaga  gacagaaaa  tctgtcctc  1020
actgtattt  taaggtttt  catgggtgt  tatatggag  acaaagttt  agccatcca  1080
agtactttc  aataagcct  tctgatttg  catctgtag  ttatgaccc  tttatgcat  1140
tggaaagtc  gagagagcc  gaacctcta  actctcctg  ttcagaacg  tcttctaaa  1200
tgcagccgg  gacagaagt  aaaactcag  tgcaacaag  attaatttc  atagcagcc  1260
gtactgtta  tacccatct  gtgaatcac  tgggccatt  tccaatgag  ggtggtcct  1320
ctatgctaa  gagtcaggt  tgtgagaat  atgacaatc  ttatagcga  agtactgaa  1380
tttctcctg  gctctttga  agtccaaat  ttcagttct  tgtgctgaa  aatacaacc  1440
tagtgtctt  tatccagat  agatcagaa  agagtgtgc  tggaggagg  ttagctgct  1500
gccttgtgt  agccaactc  aatgttaga  tcatagtac  tgatctctc  ggaaagtac  1560
catgggatt  tgccatact  tatgggcca  ccattgtaa  tggtttgcc  gaacctaca  1620
ctttcatac  ttcaatgtc  taccaagag  aaccagaag  acctcctac  tctaatgaa  1680
gcttagaag  cataacagt  aaagatgga  tttctctcc  gcttagaag  tttagagaa  1740
ctgttccaa  ttggtctac  ataagagaa  aagaagatg  tcttgatga  ctcctgcag  1800
atttacgca  tacaaatcc  gaatgttta  agagaactg  aatctccct  aatgttcct  1860
ctccacaac  tgtgtgcat  tctgaaaaa  aggagaatg  tgtcattaa  gctatcctt  1920
agcaataca  agaagaaaa  gagtttgta  aaaagcact  taatgactt  aacatgaaa  1980
cctcagaac  agatgaacc  acacctcag  aacctcagt  agcatttta  tactgcaga  2040
tgcttctta  tatattggg  atgaattcc  gggacaaac  gaggagctt  catctcctg  2100
agaaaaatg  aaagctgct  agagaactg  ggaacttgg  ttcaaggca  tgccgagaa  2160
cacacaaga  tgcagtatt  tacgttgct  aaggacaag  agataaata  tccattctc  2220
ccaatatag  aggaagcca  gcatatgaa  attttgttg  tggccttgg  tgggaggta  2280
accttacaa  tcactgtgg  ttcatggga  gactgcaga  gaacaaaag  actggactg  2340
ccactccat  ttttgctac  tctacagta  aagtaatat  tcatgtatc  acaagaatg  2400
cttctgaat  tgatgactc  ctgaccaaa  aattgagac  tctaggaaa  gatgaagta  2460
acattgttt  gtctgaaca  actagagac  acaggagag  aattattcc  acagagttt  2520
gtgatgtcc  cattgtaat  tatccaatg  aaaaccaca  gttcagtat  cagatcatg  2580
aaaagccag  ggttccctt  tttggtccc  tttttgatg  tgctattgt  aatggaaaa  2640
ttctgccca  tatggttcg  tccacagca  taaatgcta  ccgtgctct  aaatcactg  2700
ttccattgt  tcaaaactt  tacgaggag  gagcacggt  cctgcagac  attgtccag  2760
accacttag  gccaacgac  tttgaagac  ttgcagccc  ggttttctc  ccagctccc  2820
accatcatt  ccctgctga  gcaggtaag  ataaaagag  gtgttgatc  cttgtcaca  2880
acccaaaat  caataccct  ttcttctca  tcatggttg  ataaaattc  ggtcattga  2940
atatattat  catgactga  tttggcctg  aaatttcat  gtttccttt  atgtaaatg  3000
ggttgctta  atatccagt  atcctcatc  aagtgcatg  cccatatct  accacagtc  3060
ctggctcct  cttttcatg  gaatctgaa  tatctgcag  aagaactct  aacttcaga  3120
gatcaaatt  tatggccaa  aatacagtg  catcatctc  aantttaca  gtaaagcta  3180
accagtcta  attaaaagc  tttagtaca  caaattatg  tataatatt  aaagacttt  3240
agaaggtac  gcattaata  atttaacta  ttttaagga  atcagcaat  aaaatgctc  3300
tggctcgtg  cgaattcct  cagcccggg  ggatcacta  ttct  3344



<210> 817
<211> 1809
<212> PRT
<213> Rattus norvegicus
<308> P49816
<400> 817

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
  1               5                  10                  15
Ile Leu Leu Gly Leu Gly Thr Ser Arg Pro Asn Pro Arg Cys Ala Glu 
             20                  25                  30
Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
         35                  40                  45
Ser Gly Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
     50                  55                  60
Cys Asp Val Ala Lys Thr Lys Lys Leu Glu Glu His Ala Val Glu Ala 
 65                  70                  75                  80
Leu Trp Lys Ala Val Ser Asp Leu Leu Gln Pro Glu Arg Pro Pro Glu 
                 85                  90                  95
Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
             100                105                110
Gly Asp Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
         115                120                125
Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
     130                135                140
Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
 145                150                155                160
Ala Glu Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                 165                170                175
Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
             180                185                190
Glu Tyr Ile Ala Pro Met Val His Met Ile Cys Leu Leu Cys Ile Arg 
         195                200                205
Thr Val Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
     210                215                220
Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
 225                230                235                240
Ile Thr Leu Cys Arg Thr Val Asn Val Lys Glu Leu Cys Glu Pro Cys 
                 245                250                255
Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
             260                265                270
Ile Tyr Asn Met Cys Arg Ile Met Glu Asn Arg Ser Tyr Met Glu Asp 
         275                280                285
Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
     290                295                300
Gly Ala His Arg Leu Tyr Ser Leu Lys Asn Ser Pro Thr Ser Val Leu 
 305                310                315                320
Pro Ser Phe Tyr Glu Ala Met Thr Cys Pro Asn Glu Val Val Ser Tyr 
                 325                330                335
Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
             340                345                350
Leu Gln Ala Val Thr Trp Asp Ile Leu Leu Asp Ile Ile Glu Arg Leu 
         355                360                365
Leu Gln Gln Leu Gln Asn Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
     370                375                380
His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
 385                390                395                400
His Gly Ser Gln Glu Arg Tyr Tyr Glu Leu Val Glu Ser Tyr Ala Asp 
                 405                410                415
Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Thr Tyr Arg Ala Gln 
             420                425                430
Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Leu Leu 
         435                440                445
Met Glu Arg Phe Phe Arg Asn Glu Cys Arg Ser Ala Val Arg Ile Lys 
     450                455                460
Val Leu Asp Val Leu Ser Phe Val Leu Leu Ile Asn Arg Gln Phe Tyr 
 465                470                475                480
Glu Glu Glu Leu Ile Asn Ser Val Val Ile Ser Gln Leu Ser His Ile 
                 485                490                495
Pro Glu Asp Lys Asp His Gln Val Arg Lys Leu Ala Thr Gln Leu Leu 
             500                505                510
Val Asp Leu Ala Glu Gly Cys His Thr His His Phe Asn Ser Leu Leu 
         515                520                525
Asp Ile Ile Glu Lys Val Met Ala Arg Ser Leu Ser Pro Pro Leu Glu 
     530                535                540
Leu Glu Glu Arg Asp Leu Ala Val Tyr Ser Ala Ser Leu Glu Asp Val 
 545                550                555                560
Lys Thr Ala Val Leu Gly Leu Leu Val Ile Leu Gln Thr Lys Leu Tyr 
                 565                570                575
Thr Leu Pro Ala Ser His Ala Thr Arg Val Tyr Glu Thr Leu Ile Ser 
             580                585                590
His Ile Gln Leu His Tyr Lys His Gly Tyr Ser Leu Pro Ile Ala Ser 
         595                600                605
Ser Ile Arg Leu Gln Ala Phe Asp Phe Leu Leu Leu Leu Arg Ala Asp 
     610                615                620
Ser Leu His Arg Leu Gly Leu Pro Asn Lys Asp Gly Val Val Arg Phe 
 625                630                635                640
Ser Pro Tyr Cys Leu Cys Asp Cys Ala Glu Leu Asp Arg Ala Ser Glu 
                 645                650                655
Lys Lys Ala Ser Gly Pro Leu Ser Pro Pro Thr Gly Pro Pro Ser Pro 
             660                665                670
Val Pro Thr Gly Pro Ala Val Arg Leu Gly His Leu Pro Tyr Ser Leu 
         675                680                685
Leu Phe Arg Val Leu Leu Gln Cys Leu Lys Gln Glu Thr Asp Trp Lys 
     690                695                700
Val Leu Lys Leu Val Leu Ser Lys Leu Pro Glu Ser Leu Arg Tyr Lys 
 705                710                715                720
Val Leu Ile Phe Thr Ser Pro Cys Ser Val Asp Gln Leu Ser Ser Ala 
                 725                730                735
Leu Cys Ser Met Leu Ser Ala Pro Lys Thr Leu Glu Arg Leu Arg Gly 
             740                745                750
Thr Pro Glu Gly Phe Ser Arg Thr Asp Leu His Leu Ala Val Val Pro 
         755                760                765
Val Leu Thr Ala Leu Ile Ser Tyr His Asn Tyr Leu Asp Lys Thr Arg 
     770                775                780
Gln Arg Glu Met Val Tyr Cys Leu Glu Gln Gly Leu Ile Tyr Arg Cys 
 785                790                795                800
Ala Ser Gln Cys Val Val Ala Leu Ala Ile Cys Ser Val Glu Met Pro 
                 805                810                815
Asp Ile Ile Ile Lys Ala Leu Pro Val Leu Val Val Lys Leu Thr His 
             820                825                830
Ile Ser Ala Thr Ala Ser Met Ala Ile Pro Leu Leu Glu Phe Leu Ser 
         835                840                845
Thr Leu Ala Arg Leu Pro His Leu Tyr Arg Asn Phe Ala Ala Glu Gln 
     850                855                860
Tyr Ala Ser Val Phe Ala Ile Ser Leu Pro Tyr Thr Asn Pro Ser Lys 
 865                870                875                880
Phe Asn Gln Tyr Ile Val Cys Leu Ala His His Val Ile Ala Met Trp 
                 885                890                895
Phe Ile Arg Cys Arg Leu Pro Phe Arg Lys Asp Phe Val Pro Tyr Ile 
             900                905                910
Thr Lys Gly Leu Arg Ser Asn Val Leu Leu Ser Phe Asp Asp Thr Pro 
         915                920                925
Glu Lys Asp Lys Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro 
     930                935                940
Lys Ser Leu Arg Ile Ala Arg Ala Pro Lys Gln Gly Leu Asn Asn Ser 
 945                950                955                960
Pro Pro Val Lys Glu Phe Lys Glu Ser Cys Ala Ala Glu Ala Phe Arg 
                 965                970                975
Cys Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
             980                985                990
Thr Ser Leu Thr Ser Ala Ser Leu Gly Ser Ala Asp Glu Asn Ser Met 
         995                1000                1005
Ala Gln Ala Asp Asp Asn Leu Lys Asn Leu His Leu Glu Leu Thr Glu 
     1010                1015                1020
Thr Cys Leu Asp Met Met Ala Arg Tyr Val Phe Ser Asn Phe Thr Ala 
 1025                1030                1035                1040
Val Pro Lys Arg Ser Pro Val Gly Glu Phe Leu Leu Ala Gly Gly Arg 
                 1045                1050                1055
Thr Lys Thr Trp Leu Val Gly Asn Lys Leu Val Thr Val Thr Thr Ser 
             1060                1065                1070
Val Gly Thr Gly Thr Arg Ser Leu Leu Gly Leu Asp Ser Gly Asp Leu 
         1075                1080                1085
Gln Gly Gly Ser Ala Ser Ser Ser Asp Pro Gly Thr His Val Arg Gln 
     1090                1095                1100
Thr Lys Glu Ala Pro Ala Lys Leu Glu Ser Gln Ala Gly Gln Gln Val 
 1105                1110                1115                1120
Ser Arg Gly Ala Arg Asp Arg Val Arg Ser Met Ser Gly Gly His Gly 
                 1125                1130                1135
Leu Arg Val Gly Val Leu Asp Thr Ser Ala Pro Tyr Thr Pro Gly Gly 
             1140                1145                1150
Pro Ala Ser Leu Gly Ala Gln Ala Ala Pro Ala Ala Arg Pro Glu Lys 
         1155                1160                1165
Pro Cys Ala Gly Ala Gln Leu Pro Ala Ala Glu Lys Ala Asn Leu Ala 
     1170                1175                1180
Ala Tyr Val Pro Leu Leu Thr Gln Gly Trp Ala Glu Ile Leu Val Arg 
 1185                1190                1195                1200
Arg Pro Thr Gly Asn Thr Ser Trp Leu Met Ser Leu Glu Asn Pro Leu 
                 1205                1210                1215
Ser Pro Phe Ser Ser Asp Ile Asn Asn Met Pro Leu Gln Glu Leu Ser 
             1220                1225                1230
Asn Ala Leu Met Ala Ala Glu Arg Phe Lys Glu His Arg Asp Thr Ala 
         1235                1240                1245
Leu Tyr Lys Ser Leu Ser Val Pro Ala Ala Gly Thr Ala Lys Pro Pro 
     1250                1255                1260
Thr Leu Pro Arg Ser Asn Thr Val Ala Ser Phe Ser Ser Leu Tyr Gln 
 1265                1270                1275                1280
Pro Ser Cys Gln Gly Gln Leu His Arg Ser Val Ser Trp Ala Asp Ser 
                 1285                1290                1295
Ala Val Val Leu Glu Glu Gly Ser Pro Gly Glu Ala His Val Pro Val 
             1300                1305                1310
Glu Pro Pro Glu Leu Glu Asp Phe Glu Ala Ala Leu Gly Thr Asp Arg 
         1315                1320                1325
His Cys Gln Arg Pro Asp Ala Tyr Ser Arg Ser Ser Ser Ala Ser Ser 
     1330                1335                1340
Gln Glu Glu Lys Ser His Leu Glu Glu Leu Ala Ala Gly Gly Ile Pro 
 1345                1350                1355                1360
Ile Glu Arg Ala Ile Ser Ser Glu Gly Ala Arg Pro Thr Val Asp Leu 
                 1365                1370                1375
Ser Phe Gln Pro Ser Gln Pro Leu Ser Lys Ser Ser Ser Ser Pro Glu 
             1380                1385                1390
Leu Gln Thr Leu Gln Asp Ile Leu Gly Asp Leu Gly Asp Lys Thr Asp 
         1395                1400                1405
Ile Gly Arg Leu Ser Pro Glu Ala Lys Val Arg Ser Gln Ser Gly Ile 
     1410                1415                1420
Leu Asp Gly Glu Ala Ala Thr Trp Ser Ala Pro Gly Glu Glu Ser Arg 
 1425                1430                1435                1440
Ile Thr Val Pro Pro Glu Gly Pro Leu Pro Ser Ser Ser Pro Arg Ser 
                 1445                1450                1455
Pro Ser Gly Leu Arg Pro Arg Gly Tyr Thr Ile Ser Asp Ser Ala Pro 
             1460                1465                1470
Ser Arg Arg Gly Lys Arg Val Glu Arg Asp Asn Phe Lys Ser Arg Thr 
         1475                1480                1485
Ala Ala Ser Ser Ala Glu Lys Val Pro Gly Ile Asn Pro Ser Phe Val 
     1490                1495                1500
Phe Leu Gln Leu Tyr His Ser Pro Phe Cys Gly Asp Glu Ser Asn Lys 
 1505                1510                1515                1520
Pro Ile Leu Leu Pro Asn Glu Ser Phe Glu Arg Ser Val Gln Leu Leu 
                 1525                1530                1535
Asp Gln Ile Pro Ser Tyr Asp Thr His Lys Ile Ala Val Leu Tyr Val 
             1540                1545                1550
Gly Glu Gly Gln Ser Ser Ser Glu Leu Ala Ile Leu Ser Asn Glu His 
         1555                1560                1565
Gly Ser Tyr Arg Tyr Thr Glu Phe Leu Thr Gly Leu Gly Arg Leu Ile 
     1570                1575                1580
Glu Leu Lys Asp Cys Gln Pro Asp Lys Val Tyr Leu Gly Gly Leu Asp 
 1585                1590                1595                1600
Val Cys Gly Glu Asp Gly Gln Phe Thr Tyr Cys Trp His Asp Asp Ile 
                 1605                1610                1615
Met Gln Ala Val Phe His Ile Ala Thr Leu Met Pro Thr Lys Asp Val 
             1620                1625                1630
Asp Lys His Arg Cys Asp Lys Lys Arg His Leu Gly Asn Asp Phe Val 
         1635                1640                1645
Ser Ile Ile Tyr Asn Asp Ser Gly Glu Asp Phe Lys Leu Gly Thr Ile 
     1650                1655                1660
Lys Gly Gln Phe Asn Phe Val His Val Ile Ile Thr Pro Leu Asp Tyr 
 1665                1670                1675                1680
Lys Cys Asn Leu Leu Thr Leu Gln Cys Arg Lys Asp Met Glu Gly Leu 
                 1685                1690                1695
Val Asp Thr Ser Val Ala Lys Ile Val Ser Asp Arg Asn Leu Ser Phe 
             1700                1705                1710
Val Ala Arg Gln Met Ala Leu His Ala Asn Met Ala Ser Gln Val His 
         1715                1720                1725
His Arg Arg Ser Asn Pro Thr Asp Ile Tyr Pro Ser Lys Trp Ile Ala 
     1730                1735                1740
Arg Leu Arg His Ile Lys Arg Leu Arg Gln Arg Ile Arg Glu Glu Val 
 1745                1750                1755                1760
His Tyr Ser Asn Pro Ser Leu Pro Leu Met His Pro Pro Ala His Thr 
                 1765                1770                1775
Lys Val Pro Ala Gln Ala Pro Thr Glu Ala Thr Pro Thr Tyr Glu Thr 
             1780                1785                1790
Gly Gln Arg Lys Arg Leu Ile Ser Ser Val Asp Asp Phe Thr Glu Phe 
         1795                1800                1805
Val 
     1810



<210> 818
<211> 2121
<212> DNA
<213> Homo sapiens
<308> AL050050
<400> 818

aaagatgga  tttccagtt  aaaagattt  gagaaactg  accaacttg  gatacaata  60
gagatgaag  agatgctct  gatgaactc  tgcagtatt  gggtgttac  agtcctgaa  120
gcttacaga  aactggaat  tcacttaat  ttcctgctc  acaacctgt  tgcatttct  180
aaaaacaag  aagtgatgt  attaatgct  tccttaagc  acatacaga  gaaaaagaa  240
ttgttgaga  gcactttaa  gacttaaac  tgaaagctg  ggaacaaga  gaaccaata  300
ctcaaaaac  tcagtcagc  ttttattat  gcagattgc  tcttagtat  ttgggaatg  360
attcctggg  caaacggag  agctttcat  tcctgaaga  aaatgaaaa  ctacttaga  420
aacttagga  cttggattc  aggcagtgc  gagagacac  caagattgc  gtattttat  480
ttgctgaag  acaagaaga  aaacactcc  ttctcacca  tacaggagg  agtcaagca  540
atgaagatt  tgtagctgg  cttggttgg  aggtaaatc  tacaaacca  tgtggtttt  600
tgggaggac  acaaaaaaa  aaaagcact  gattgacca  tccatattt  gctacctct  660
cagtagaag  aatatttca  atgtcaaca  gaatgcctt  tgattctga  gattctttg  720
ccaaaaaat  gagacattt  ggaaatgat  aagtgcaca  tgtttggtc  gagcatact  780
gagactaca  gagaggaat  attcccaca  aatttggtg  tgtccttat  gtaatatat  840
caatgaaaa  tcacatgtt  agtattcag  taatgagaa  accagaggt  cccttcttt  900
gtccccttt  tgatggtgc  attgtgaat  gaaaggttc  acccattat  gttagagca  960
cagctataa  tgcaagccg  gctctgaaa  ctctgattc  attgtatca  aacttctat  1020
aggagagag  acgatacct  caaacaatt  tccagcacc  cttagaacc  acaacattt  1080
aagattttg  agcacaggt  ttttctcca  ctccctacc  ccatttacc  tctggtgcc  1140
atcattaaa  atcagttct  tttatctga  ggctcctac  cagagattc  acccagtga  1200
actcccaca  cagcgcagg  agatggggc  gacctggcc  ctccaatgt  tcctcgaac  1260
agcaaaagc  gcatgtcca  gaagctgcg  cgttcctct  gctcagcca  taaatccta  1320
ggagacaag  agcccagca  tgatcagca  tagccacct  agcatggac  tagggttaa  1380
cctttcagg  cttcatgtc  gccataaca  gcatgtttc  tcctgtaca  ttatttgag  1440
aaacactgg  tttaaataa  tttaaataa  ttgtagctt  atattaaag  tttaagtta  1500
ttattgttt  atttttttc  cacaatcca  gctgccata  tttgagggc  gggggagtt  1560
tattctaca  cctttacct  cctagataa  tatgtctaa  tagttttat  tttaatttc  1620
tggttaact  tgagccaaa  tacaattgg  caattagtc  cattattta  tgtgctcca  1680
tgcaacttt  tggttcaat  aatatataa  tttttacaa  tgtaaaatt  tacatttaa  1740
catttgtaa  gttacagca  aagatgtac  tgttaatac  cagaatgtg  acagattat  1800
tgttatgac  ataaaacac  caaaataaa  ggtctttag  atctcaaat  ccaactgaa  1860
tcattttag  attaactct  cttcccaaa  caatgtctc  tttcttggc  gtgcaggtg  1920
tgccatgtt  tatccaata  ctagaaaaa  cactgtgct  aacttttat  tttagcttc  1980
aagtatttt  ctaatgttt  gcatttcaa  tggtatcac  gttaaatgc  atttgtttt  2040
agattgtgg  cttttatta  tggctgcta  atcctggtg  ttctatgtt  ttttttaag  2100
accaaaaaa  aaaaaaaaa  a  2121



<210> 819
<211> 3344
<212> DNA
<213> Rattus norvegicus
<308> AF041107
<400> 819

gcattatgg  gtagttatt  atngcaccc  ggcttaaaa  ttangttcc  gntngtatg  60
ggggggaat  ggagcggat  acaattcac  cnggaaaca  ttagaccat  attangatt  120
ctaacacct  ggcttttta  ggcaaccat  ttgactgat  agtataaac  agntaaatt  180
catgcatat  aatttattt  taatacaat  aagagagac  agatgtatc  ccaaataga  240
attttttaa  gcatttcta  aatataatg  attgtggat  gcttcatat  gaccaggac  300
tcgtcaata  gatcatcaa  cactgctca  ctcagtttt  ttcacttgg  ttgcctggg  360
ccacaatgc  tattatgga  tttattata  cggctggga  agtggcttc  tcagctttt  420
ttaatgcac  aagagtgga  gcacaggtt  ttctgggat  tttggtttg  ttccccaac  480
tatactgtg  gctgcctgc  ctgcatcca  gcacgcctg  catcgctgt  tctcagttc  540
cagacgtca  ggaacttat  attaaaact  tcttaagct  ggcaagaga  gaaccctct  600
gccctgcac  atgtgtagc  ctttgcagt  taggtatat  gatttgtga  gaattagtc  660
acgaatctc  tcatcctca  attaaagaa  cactgaatg  aatttgtgt  tcattaaag  720
ttactaata  aacagttgc  catgtagct  gtaacatgc  tcacatgct  gttcattat  780
cacctagac  tcagactta  cagcctgac  ctcccttga  aattattca  atcctaata  840
caactatca  acacctttt  ccaagtaca  aagcttcat  atatgaaat  gacaagagg  900
tggttgtgt  attacttct  tgccttctg  actggatca  ggccttacc  ttaaagaca  960
tactccaat  agtccattc  acaggagca  aaaatgaga  gacagaaaa  tctgtcctc  1020
actgtattt  taaggtttt  catgggtgt  tatatggag  acaaagttt  agccatcca  1080
agtactttc  aataagcct  tctgatttg  catctgtag  ttatgaccc  tttatgcat  1140
tggaaagtc  gagagagcc  gaacctcta  actctcctg  ttcagaacg  tcttctaaa  1200
tgcagccgg  gacagaagt  aaaactcag  tgcaacaag  attaatttc  atagcagcc  1260
gtactgtta  tacccatct  gtgaatcac  tgggccatt  tccaatgag  ggtggtcct  1320
ctatgctaa  gagtcaggt  tgtgagaat  atgacaatc  ttatagcga  agtactgaa  1380
tttctcctg  gctctttga  agtccaaat  ttcagttct  tgtgctgaa  aatacaacc  1440
tagtgtctt  tatccagat  agatcagaa  agagtgtgc  tggaggagg  ttagctgct  1500
gccttgtgt  agccaactc  aatgttaga  tcatagtac  tgatctctc  ggaaagtac  1560
catgggatt  tgccatact  tatgggcca  ccattgtaa  tggtttgcc  gaacctaca  1620
ctttcatac  ttcaatgtc  taccaagag  aaccagaag  acctcctac  tctaatgaa  1680
gcttagaag  cataacagt  aaagatgga  tttctctcc  gcttagaag  tttagagaa  1740
ctgttccaa  ttggtctac  ataagagaa  aagaagatg  tcttgatga  ctcctgcag  1800
atttacgca  tacaaatcc  gaatgttta  agagaactg  aatctccct  aatgttcct  1860
ctccacaac  tgtgtgcat  tctgaaaaa  aggagaatg  tgtcattaa  gctatcctt  1920
agcaataca  agaagaaaa  gagtttgta  aaaagcact  taatgactt  aacatgaaa  1980
cctcagaac  agatgaacc  acacctcag  aacctcagt  agcatttta  tactgcaga  2040
tgcttctta  tatattggg  atgaattcc  gggacaaac  gaggagctt  catctcctg  2100
agaaaaatg  aaagctgct  agagaactg  ggaacttgg  ttcaaggca  tgccgagaa  2160
cacacaaga  tgcagtatt  tacgttgct  aaggacaag  agataaata  tccattctc  2220
ccaatatag  aggaagcca  gcatatgaa  attttgttg  tggccttgg  tgggaggta  2280
accttacaa  tcactgtgg  ttcatggga  gactgcaga  gaacaaaag  actggactg  2340
ccactccat  ttttgctac  tctacagta  aagtaatat  tcatgtatc  acaagaatg  2400
cttctgaat  tgatgactc  ctgaccaaa  aattgagac  tctaggaaa  gatgaagta  2460
acattgttt  gtctgaaca  actagagac  acaggagag  aattattcc  acagagttt  2520
gtgatgtcc  cattgtaat  tatccaatg  aaaaccaca  gttcagtat  cagatcatg  2580
aaaagccag  ggttccctt  tttggtccc  tttttgatg  tgctattgt  aatggaaaa  2640
ttctgccca  tatggttcg  tccacagca  taaatgcta  ccgtgctct  aaatcactg  2700
ttccattgt  tcaaaactt  tacgaggag  gagcacggt  cctgcagac  attgtccag  2760
accacttag  gccaacgac  tttgaagac  ttgcagccc  ggttttctc  ccagctccc  2820
accatcatt  ccctgctga  gcaggtaag  ataaaagag  gtgttgatc  cttgtcaca  2880
acccaaaat  caataccct  ttcttctca  tcatggttg  ataaaattc  ggtcattga  2940
atatattat  catgactga  tttggcctg  aaatttcat  gtttccttt  atgtaaatg  3000
ggttgctta  atatccagt  atcctcatc  aagtgcatg  cccatatct  accacagtc  3060
ctggctcct  cttttcatg  gaatctgaa  tatctgcag  aagaactct  aacttcaga  3120
gatcaaatt  tatggccaa  aatacagtg  catcatctc  aantttaca  gtaaagcta  3180
accagtcta  attaaaagc  tttagtaca  caaattatg  tataatatt  aaagacttt  3240
agaaggtac  gcattaata  atttaacta  ttttaagga  atcagcaat  aaaatgctc  3300
tggctcgtg  cgaattcct  cagcccggg  ggatcacta  ttct  3344



<210> 820
<211> 1809
<212> PRT
<213> Rattus norvegicus
<308> P49816
<400> 820

Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
  1               5                  10                  15
Ile Leu Leu Gly Leu Gly Thr Ser Arg Pro Asn Pro Arg Cys Ala Glu 
             20                  25                  30
Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
         35                  40                  45
Ser Gly Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
     50                  55                  60
Cys Asp Val Ala Lys Thr Lys Lys Leu Glu Glu His Ala Val Glu Ala 
 65                  70                  75                  80
Leu Trp Lys Ala Val Ser Asp Leu Leu Gln Pro Glu Arg Pro Pro Glu 
                 85                  90                  95
Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
             100                105                110
Gly Asp Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
         115                120                125
Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
     130                135                140
Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
 145                150                155                160
Ala Glu Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                 165                170                175
Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
             180                185                190
Glu Tyr Ile Ala Pro Met Val His Met Ile Cys Leu Leu Cys Ile Arg 
         195                200                205
Thr Val Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
     210                215                220
Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
 225                230                235                240
Ile Thr Leu Cys Arg Thr Val Asn Val Lys Glu Leu Cys Glu Pro Cys 
                 245                250                255
Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
             260                265                270
Ile Tyr Asn Met Cys Arg Ile Met Glu Asn Arg Ser Tyr Met Glu Asp 
         275                280                285
Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
     290                295                300
Gly Ala His Arg Leu Tyr Ser Leu Lys Asn Ser Pro Thr Ser Val Leu 
 305                310                315                320
Pro Ser Phe Tyr Glu Ala Met Thr Cys Pro Asn Glu Val Val Ser Tyr 
                 325                330                335
Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
             340                345                350
Leu Gln Ala Val Thr Trp Asp Ile Leu Leu Asp Ile Ile Glu Arg Leu 
         355                360                365
Leu Gln Gln Leu Gln Asn Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
     370                375                380
His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
 385                390                395                400
His Gly Ser Gln Glu Arg Tyr Tyr Glu Leu Val Glu Ser Tyr Ala Asp 
                 405                410                415
Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Thr Tyr Arg Ala Gln 
             420                425                430
Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Leu Leu 
         435                440                445
Met Glu Arg Phe Phe Arg Asn Glu Cys Arg Ser Ala Val Arg Ile Lys 
     450                455                460
Val Leu Asp Val Leu Ser Phe Val Leu Leu Ile Asn Arg Gln Phe Tyr 
 465                470                475                480
Glu Glu Glu Leu Ile Asn Ser Val Val Ile Ser Gln Leu Ser His Ile 
                 485                490                495
Pro Glu Asp Lys Asp His Gln Val Arg Lys Leu Ala Thr Gln Leu Leu 
             500                505                510
Val Asp Leu Ala Glu Gly Cys His Thr His His Phe Asn Ser Leu Leu 
         515                520                525
Asp Ile Ile Glu Lys Val Met Ala Arg Ser Leu Ser Pro Pro Leu Glu 
     530                535                540
Leu Glu Glu Arg Asp Leu Ala Val Tyr Ser Ala Ser Leu Glu Asp Val 
 545                550                555                560
Lys Thr Ala Val Leu Gly Leu Leu Val Ile Leu Gln Thr Lys Leu Tyr 
                 565                570                575
Thr Leu Pro Ala Ser His Ala Thr Arg Val Tyr Glu Thr Leu Ile Ser 
             580                585                590
His Ile Gln Leu His Tyr Lys His Gly Tyr Ser Leu Pro Ile Ala Ser 
         595                600                605
Ser Ile Arg Leu Gln Ala Phe Asp Phe Leu Leu Leu Leu Arg Ala Asp 
     610                615                620
Ser Leu His Arg Leu Gly Leu Pro Asn Lys Asp Gly Val Val Arg Phe 
 625                630                635                640
Ser Pro Tyr Cys Leu Cys Asp Cys Ala Glu Leu Asp Arg Ala Ser Glu 
                 645                650                655
Lys Lys Ala Ser Gly Pro Leu Ser Pro Pro Thr Gly Pro Pro Ser Pro 
             660                665                670
Val Pro Thr Gly Pro Ala Val Arg Leu Gly His Leu Pro Tyr Ser Leu 
         675                680                685
Leu Phe Arg Val Leu Leu Gln Cys Leu Lys Gln Glu Thr Asp Trp Lys 
     690                695                700
Val Leu Lys Leu Val Leu Ser Lys Leu Pro Glu Ser Leu Arg Tyr Lys 
 705                710                715                720
Val Leu Ile Phe Thr Ser Pro Cys Ser Val Asp Gln Leu Ser Ser Ala 
                 725                730                735
Leu Cys Ser Met Leu Ser Ala Pro Lys Thr Leu Glu Arg Leu Arg Gly 
             740                745                750
Thr Pro Glu Gly Phe Ser Arg Thr Asp Leu His Leu Ala Val Val Pro 
         755                760                765
Val Leu Thr Ala Leu Ile Ser Tyr His Asn Tyr Leu Asp Lys Thr Arg 
     770                775                780
Gln Arg Glu Met Val Tyr Cys Leu Glu Gln Gly Leu Ile Tyr Arg Cys 
 785                790                795                800
Ala Ser Gln Cys Val Val Ala Leu Ala Ile Cys Ser Val Glu Met Pro 
                 805                810                815
Asp Ile Ile Ile Lys Ala Leu Pro Val Leu Val Val Lys Leu Thr His 
             820                825                830
Ile Ser Ala Thr Ala Ser Met Ala Ile Pro Leu Leu Glu Phe Leu Ser 
         835                840                845
Thr Leu Ala Arg Leu Pro His Leu Tyr Arg Asn Phe Ala Ala Glu Gln 
     850                855                860
Tyr Ala Ser Val Phe Ala Ile Ser Leu Pro Tyr Thr Asn Pro Ser Lys 
 865                870                875                880
Phe Asn Gln Tyr Ile Val Cys Leu Ala His His Val Ile Ala Met Trp 
                 885                890                895
Phe Ile Arg Cys Arg Leu Pro Phe Arg Lys Asp Phe Val Pro Tyr Ile 
             900                905                910
Thr Lys Gly Leu Arg Ser Asn Val Leu Leu Ser Phe Asp Asp Thr Pro 
         915                920                925
Glu Lys Asp Lys Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro 
     930                935                940
Lys Ser Leu Arg Ile Ala Arg Ala Pro Lys Gln Gly Leu Asn Asn Ser 
 945                950                955                960
Pro Pro Val Lys Glu Phe Lys Glu Ser Cys Ala Ala Glu Ala Phe Arg 
                 965                970                975
Cys Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
             980                985                990
Thr Ser Leu Thr Ser Ala Ser Leu Gly Ser Ala Asp Glu Asn Ser Met 
         995                1000                1005
Ala Gln Ala Asp Asp Asn Leu Lys Asn Leu His Leu Glu Leu Thr Glu 
     1010                1015                1020
Thr Cys Leu Asp Met Met Ala Arg Tyr Val Phe Ser Asn Phe Thr Ala 
 1025                1030                1035                1040
Val Pro Lys Arg Ser Pro Val Gly Glu Phe Leu Leu Ala Gly Gly Arg 
                 1045                1050                1055
Thr Lys Thr Trp Leu Val Gly Asn Lys Leu Val Thr Val Thr Thr Ser 
             1060                1065                1070
Val Gly Thr Gly Thr Arg Ser Leu Leu Gly Leu Asp Ser Gly Asp Leu 
         1075                1080                1085
Gln Gly Gly Ser Ala Ser Ser Ser Asp Pro Gly Thr His Val Arg Gln 
     1090                1095                1100
Thr Lys Glu Ala Pro Ala Lys Leu Glu Ser Gln Ala Gly Gln Gln Val 
 1105                1110                1115                1120
Ser Arg Gly Ala Arg Asp Arg Val Arg Ser Met Ser Gly Gly His Gly 
                 1125                1130                1135
Leu Arg Val Gly Val Leu Asp Thr Ser Ala Pro Tyr Thr Pro Gly Gly 
             1140                1145                1150
Pro Ala Ser Leu Gly Ala Gln Ala Ala Pro Ala Ala Arg Pro Glu Lys 
         1155                1160                1165
Pro Cys Ala Gly Ala Gln Leu Pro Ala Ala Glu Lys Ala Asn Leu Ala 
     1170                1175                1180
Ala Tyr Val Pro Leu Leu Thr Gln Gly Trp Ala Glu Ile Leu Val Arg 
 1185                1190                1195                1200
Arg Pro Thr Gly Asn Thr Ser Trp Leu Met Ser Leu Glu Asn Pro Leu 
                 1205                1210                1215
Ser Pro Phe Ser Ser Asp Ile Asn Asn Met Pro Leu Gln Glu Leu Ser 
             1220                1225                1230
Asn Ala Leu Met Ala Ala Glu Arg Phe Lys Glu His Arg Asp Thr Ala 
         1235                1240                1245
Leu Tyr Lys Ser Leu Ser Val Pro Ala Ala Gly Thr Ala Lys Pro Pro 
     1250                1255                1260
Thr Leu Pro Arg Ser Asn Thr Val Ala Ser Phe Ser Ser Leu Tyr Gln 
 1265                1270                1275                1280
Pro Ser Cys Gln Gly Gln Leu His Arg Ser Val Ser Trp Ala Asp Ser 
                 1285                1290                1295
Ala Val Val Leu Glu Glu Gly Ser Pro Gly Glu Ala His Val Pro Val 
             1300                1305                1310
Glu Pro Pro Glu Leu Glu Asp Phe Glu Ala Ala Leu Gly Thr Asp Arg 
         1315                1320                1325
His Cys Gln Arg Pro Asp Ala Tyr Ser Arg Ser Ser Ser Ala Ser Ser 
     1330                1335                1340
Gln Glu Glu Lys Ser His Leu Glu Glu Leu Ala Ala Gly Gly Ile Pro 
 1345                1350                1355                1360
Ile Glu Arg Ala Ile Ser Ser Glu Gly Ala Arg Pro Thr Val Asp Leu 
                 1365                1370                1375
Ser Phe Gln Pro Ser Gln Pro Leu Ser Lys Ser Ser Ser Ser Pro Glu 
             1380                1385                1390
Leu Gln Thr Leu Gln Asp Ile Leu Gly Asp Leu Gly Asp Lys Thr Asp 
         1395                1400                1405
Ile Gly Arg Leu Ser Pro Glu Ala Lys Val Arg Ser Gln Ser Gly Ile 
     1410                1415                1420
Leu Asp Gly Glu Ala Ala Thr Trp Ser Ala Pro Gly Glu Glu Ser Arg 
 1425                1430                1435                1440
Ile Thr Val Pro Pro Glu Gly Pro Leu Pro Ser Ser Ser Pro Arg Ser 
                 1445                1450                1455
Pro Ser Gly Leu Arg Pro Arg Gly Tyr Thr Ile Ser Asp Ser Ala Pro 
             1460                1465                1470
Ser Arg Arg Gly Lys Arg Val Glu Arg Asp Asn Phe Lys Ser Arg Thr 
         1475                1480                1485
Ala Ala Ser Ser Ala Glu Lys Val Pro Gly Ile Asn Pro Ser Phe Val 
     1490                1495                1500
Phe Leu Gln Leu Tyr His Ser Pro Phe Cys Gly Asp Glu Ser Asn Lys 
 1505                1510                1515                1520
Pro Ile Leu Leu Pro Asn Glu Ser Phe Glu Arg Ser Val Gln Leu Leu 
                 1525                1530                1535
Asp Gln Ile Pro Ser Tyr Asp Thr His Lys Ile Ala Val Leu Tyr Val 
             1540                1545                1550
Gly Glu Gly Gln Ser Ser Ser Glu Leu Ala Ile Leu Ser Asn Glu His 
         1555                1560                1565
Gly Ser Tyr Arg Tyr Thr Glu Phe Leu Thr Gly Leu Gly Arg Leu Ile 
     1570                1575                1580
Glu Leu Lys Asp Cys Gln Pro Asp Lys Val Tyr Leu Gly Gly Leu Asp 
 1585                1590                1595                1600
Val Cys Gly Glu Asp Gly Gln Phe Thr Tyr Cys Trp His Asp Asp Ile 
                 1605                1610                1615
Met Gln Ala Val Phe His Ile Ala Thr Leu Met Pro Thr Lys Asp Val 
             1620                1625                1630
Asp Lys His Arg Cys Asp Lys Lys Arg His Leu Gly Asn Asp Phe Val 
         1635                1640                1645
Ser Ile Ile Tyr Asn Asp Ser Gly Glu Asp Phe Lys Leu Gly Thr Ile 
     1650                1655                1660
Lys Gly Gln Phe Asn Phe Val His Val Ile Ile Thr Pro Leu Asp Tyr 
 1665                1670                1675                1680
Lys Cys Asn Leu Leu Thr Leu Gln Cys Arg Lys Asp Met Glu Gly Leu 
                 1685                1690                1695
Val Asp Thr Ser Val Ala Lys Ile Val Ser Asp Arg Asn Leu Ser Phe 
             1700                1705                1710
Val Ala Arg Gln Met Ala Leu His Ala Asn Met Ala Ser Gln Val His 
         1715                1720                1725
His Arg Arg Ser Asn Pro Thr Asp Ile Tyr Pro Ser Lys Trp Ile Ala 
     1730                1735                1740
Arg Leu Arg His Ile Lys Arg Leu Arg Gln Arg Ile Arg Glu Glu Val 
 1745                1750                1755                1760
His Tyr Ser Asn Pro Ser Leu Pro Leu Met His Pro Pro Ala His Thr 
                 1765                1770                1775
Lys Val Pro Ala Gln Ala Pro Thr Glu Ala Thr Pro Thr Tyr Glu Thr 
             1780                1785                1790
Gly Gln Arg Lys Arg Leu Ile Ser Ser Val Asp Asp Phe Thr Glu Phe 
         1795                1800                1805
Val 
     1810



<210> 821
<211> 2121
<212> DNA
<213> Homo sapiens
<308> AL050050
<400> 821

aaagatgga  tttccagtt  aaaagattt  gagaaactg  accaacttg  gatacaata  60
gagatgaag  agatgctct  gatgaactc  tgcagtatt  gggtgttac  agtcctgaa  120
gcttacaga  aactggaat  tcacttaat  ttcctgctc  acaacctgt  tgcatttct  180
aaaaacaag  aagtgatgt  attaatgct  tccttaagc  acatacaga  gaaaaagaa  240
ttgttgaga  gcactttaa  gacttaaac  tgaaagctg  ggaacaaga  gaaccaata  300
ctcaaaaac  tcagtcagc  ttttattat  gcagattgc  tcttagtat  ttgggaatg  360
attcctggg  caaacggag  agctttcat  tcctgaaga  aaatgaaaa  ctacttaga  420
aacttagga  cttggattc  aggcagtgc  gagagacac  caagattgc  gtattttat  480
ttgctgaag  acaagaaga  aaacactcc  ttctcacca  tacaggagg  agtcaagca  540
atgaagatt  tgtagctgg  cttggttgg  aggtaaatc  tacaaacca  tgtggtttt  600
tgggaggac  acaaaaaaa  aaaagcact  gattgacca  tccatattt  gctacctct  660
cagtagaag  aatatttca  atgtcaaca  gaatgcctt  tgattctga  gattctttg  720
ccaaaaaat  gagacattt  ggaaatgat  aagtgcaca  tgtttggtc  gagcatact  780
gagactaca  gagaggaat  attcccaca  aatttggtg  tgtccttat  gtaatatat  840
caatgaaaa  tcacatgtt  agtattcag  taatgagaa  accagaggt  cccttcttt  900
gtccccttt  tgatggtgc  attgtgaat  gaaaggttc  acccattat  gttagagca  960
cagctataa  tgcaagccg  gctctgaaa  ctctgattc  attgtatca  aacttctat  1020
aggagagag  acgatacct  caaacaatt  tccagcacc  cttagaacc  acaacattt  1080
aagattttg  agcacaggt  ttttctcca  ctccctacc  ccatttacc  tctggtgcc  1140
atcattaaa  atcagttct  tttatctga  ggctcctac  cagagattc  acccagtga  1200
actcccaca  cagcgcagg  agatggggc  gacctggcc  ctccaatgt  tcctcgaac  1260
agcaaaagc  gcatgtcca  gaagctgcg  cgttcctct  gctcagcca  taaatccta  1320
ggagacaag  agcccagca  tgatcagca  tagccacct  agcatggac  tagggttaa  1380
cctttcagg  cttcatgtc  gccataaca  gcatgtttc  tcctgtaca  ttatttgag  1440
aaacactgg  tttaaataa  tttaaataa  ttgtagctt  atattaaag  tttaagtta  1500
ttattgttt  atttttttc  cacaatcca  gctgccata  tttgagggc  gggggagtt  1560
tattctaca  cctttacct  cctagataa  tatgtctaa  tagttttat  tttaatttc  1620
tggttaact  tgagccaaa  tacaattgg  caattagtc  cattattta  tgtgctcca  1680
tgcaacttt  tggttcaat  aatatataa  tttttacaa  tgtaaaatt  tacatttaa  1740
catttgtaa  gttacagca  aagatgtac  tgttaatac  cagaatgtg  acagattat  1800
tgttatgac  ataaaacac  caaaataaa  ggtctttag  atctcaaat  ccaactgaa  1860
tcattttag  attaactct  cttcccaaa  caatgtctc  tttcttggc  gtgcaggtg  1920
tgccatgtt  tatccaata  ctagaaaaa  cactgtgct  aacttttat  tttagcttc  1980
aagtatttt  ctaatgttt  gcatttcaa  tggtatcac  gttaaatgc  atttgtttt  2040
agattgtgg  cttttatta  tggctgcta  atcctggtg  ttctatgtt  ttttttaag  2100
accaaaaaa  aaaaaaaaa  a  2121



<210> 822
<211> 1921
<212> DNA
<213> Rattus norvegicus
<308> AF041373
<400> 822

gaggggtgg  ggacgagct  cagagatgt  tggccagag  ctgacggac  gaatcaccg  60
ggcccagca  agtgtcact  gctccgcgg  atctaagac  gtatgcaag  ccacgaccc  120
cgagatcat  ggccccaag  aaaagcacc  ggactactt  attcagtgt  caaatgaga  180
gaatgtgaa  atcccacag  tggcagaca  tttgtttga  agaactact  atagtagtt  240
ggtggtggt  ttcaaatca  tcattacaa  tcatcattt  atggtgtat  gaaacgagc  300
tttcattca  tatttggct  caagaaaca  attgtttaa  ttaagcaac  ttttggata  360
aagtggatt  caaggatat  atatgtcta  atttattag  cgatatagt  ggtacctaa  420
tgaaaaggc  gtttcatac  gacaagttg  attcgattt  acaaaagtg  agagaggag  480
tgatggagt  atgagaaca  tgaacacag  aaaactgtt  aaaactgta  caattatcc  540
aaatcaaat  gatgcactt  ttgatttta  tgttaatag  aatgaactt  caaatgggg  600
aataaatgc  gccttcatg  tcctgttca  agatgccat  agactattt  cagcataca  660
tgaaggaat  attaattta  tggaaaaat  ttttgatat  aaaaagaac  agtgcaaag  720
aggtcttga  atctataag  agtttttga  taggatgac  agaatctca  agtttctga  780
agttgcaga  caagttgga  ttgacagag  agatattcc  gatctttca  aggccccca  840
cagtcttct  gatgcttta  aacaacatt  agcttcctt  gaagggaag  aaatcaaag  900
ttccacagc  gcaagcagg  ctacaacac  ttccaatgc  gtctcttct  tggcaagca  960
tggcctatc  ctgaccaaa  tggatgaaa  ggaaaagca  gcagcatta  aggaagaac  1020
ggctcgatt  aaagcacta  aggaacagc  tctaaaaga  cttgcaaag  aaccgcata  1080
ctctttaac  actgcagcc  ctcctgtgt  cacctcagc  gggggaata  tgactgcac  1140
agccatcga  atattttct  cccctagtt  ttctaacag  acatccaag  tgccaaatg  1200
cctgcttga  ttgcagcag  caacctttc  tccatctgt  catgctatg  cagctgctc  1260
tcaggtagc  agtacatgg  gaggattca  tccttctcc  gttacacag  cacatcctt  1320
agctggcct  aatgttgac  ttgaatctg  gtttggaaa  aagtctacg  atgttgctg  1380
agattctgg  ggtggactt  tcaaaccaa  agtggcctc  cagaaccag  gtcttcctg  1440
tgccaaact  ccgcctaac  aattagtgt  tgatgactt  gattcatct  tagccaacc  1500
tgtgggcaa  cttggcatt  gaaatggaa  cactaagaa  gatgtaagt  gcagtcaac  1560
aggtgaaaa  aagttaact  gaggatcta  ctggcaacc  aaggtcgca  caacaactg  1620
ctggagtgc  gcaacaatg  caccccctg  aatggccta  cctgctact  caccaacgg  1680
catgatagg  tatggaatt  ctcctcaga  gggaagtgt  cctgtaatg  cacagccaa  1740
cttaatata  agccagcct  tcatgagac  gccaaaccc  tttggccct  taccaggag  1800
acagataca  tttatgtaa  tagatggaa  agaatggaa  tactccaag  atagaagtg  1860
acaggtggc  actccttac  tccagcaaa  tccaaactg  tgtctctaa  actcttcct  1920
c  1921



<210> 823
<211> 597
<212> PRT
<213> Rattus norvegicus
<308> AAB97078
<400> 823

Met Ser Gly Gln Ser Leu Thr Asp Arg Ile Thr Ala Ala Gln His Ser 
  1               5                  10                  15
Val Thr Gly Ser Ala Val Ser Lys Thr Val Cys Lys Ala Thr Thr His 
             20                  25                  30
Glu Ile Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Cys 
         35                  40                  45
Thr Asn Glu Met Asn Val Asn Ile Pro Gln Leu Ala Asp Ser Leu Phe 
     50                  55                  60
Glu Arg Thr Thr Asn Ser Ser Trp Val Val Val Phe Lys Ser Leu Ile 
 65                  70                  75                  80
Thr Thr His His Leu Met Val Tyr Gly Asn Glu Arg Phe Ile Gln Tyr 
                 85                  90                  95
Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys 
             100                105                110
Ser Gly Leu Gln Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser 
         115                120                125
Arg Tyr Leu Asn Glu Lys Ala Val Ser Tyr Arg Gln Val Ala Phe Asp 
     130                135                140
Phe Thr Lys Val Lys Arg Gly Ala Asp Gly Val Met Arg Thr Met Asn 
 145                150                155                160
Thr Glu Lys Leu Leu Lys Thr Val Pro Ile Ile Gln Asn Gln Met Asp 
                 165                170                175
Ala Leu Leu Asp Phe Asn Val Asn Ser Asn Glu Leu Thr Asn Gly Val 
             180                185                190
Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Ala Ile Arg Leu Phe 
         195                200                205
Ala Ala Tyr Asn Glu Gly Ile Ile Asn Leu Leu Glu Lys Tyr Phe Asp 
     210                215                220
Met Lys Lys Asn Gln Cys Lys Glu Gly Leu Asp Ile Tyr Lys Lys Phe 
 225                230                235                240
Leu Thr Arg Met Thr Arg Ile Ser Glu Phe Leu Lys Val Ala Glu Gln 
                 245                250                255
Val Gly Ile Asp Arg Gly Asp Ile Pro Asp Leu Ser Gln Ala Pro Ser 
             260                265                270
Ser Leu Leu Asp Ala Leu Glu Gln His Leu Ala Ser Leu Glu Gly Lys 
         275                280                285
Lys Ile Lys Asp Ser Thr Ala Ala Ser Arg Ala Thr Thr Leu Ser Asn 
     290                295                300
Ala Val Ser Ser Leu Ala Ser Thr Gly Leu Ser Leu Thr Lys Val Asp 
 305                310                315                320
Glu Arg Glu Lys Gln Ala Ala Leu Glu Glu Glu Gln Ala Arg Leu Lys 
                 325                330                335
Ala Leu Lys Glu Gln Arg Leu Lys Glu Leu Ala Lys Lys Pro His Thr 
             340                345                350
Ser Leu Thr Thr Ala Ala Ser Pro Val Ser Thr Ser Ala Gly Gly Ile 
         355                360                365
Met Thr Ala Pro Ala Ile Asp Ile Phe Ser Thr Pro Ser Ser Ser Asn 
     370                375                380
Ser Thr Ser Lys Leu Pro Asn Asp Leu Leu Asp Leu Gln Gln Pro Thr 
 385                390                395                400
Phe His Pro Ser Val His Ala Met Ser Ala Ala Pro Gln Val Ala Ser 
                 405                410                415
Thr Trp Gly Gly Phe Ser Pro Ser Pro Val Thr Gln Pro His Pro Ser 
             420                425                430
Ala Gly Leu Asn Val Asp Phe Glu Ser Val Phe Gly Asn Lys Ser Thr 
         435                440                445
Asn Val Ala Val Asp Ser Gly Gly Gly Leu Leu Lys Pro Thr Val Ala 
     450                455                460
Ser Gln Asn Gln Ser Leu Pro Val Ala Lys Leu Pro Pro Asn Lys Leu 
 465                470                475                480
Val Ser Asp Asp Leu Asp Ser Ser Leu Ala Asn Leu Val Gly Asn Leu 
                 485                490                495
Gly Ile Gly Asn Gly Thr Thr Lys Asn Asp Val Ser Cys Ser Gln Pro 
             500                505                510
Gly Glu Lys Lys Leu Thr Gly Gly Ser Asn Trp Gln Pro Lys Val Ala 
         515                520                525
Pro Thr Thr Ala Trp Ser Ala Ala Thr Met Ala Pro Pro Val Met Ala 
     530                535                540
Tyr Pro Ala Thr Thr Pro Thr Gly Met Ile Gly Tyr Gly Ile Pro Pro 
 545                550                555                560
Gln Met Gly Ser Val Pro Val Met Thr Gln Pro Thr Leu Ile Tyr Ser 
                 565                570                575
Gln Pro Val Met Arg Pro Pro Asn Pro Phe Gly Pro Val Pro Gly Ala 
             580                585                590
Gln Ile Gln Phe Met 
         595



<210> 824
<211> 2343
<212> DNA
<213> Homo sapiens
<308> NM_007166
<400> 824

gcgcggccc  gaaccgccg  caggccggc  cgggggaag  agccggtgg  ggtaggggg  60
gcggtgggg  gtggggacc  tccggctct  gggggtccc  gtccccgcc  gctgctgag  120
gggtggggt  gtggaggag  tgcagagat  tccggccag  gcctgacgg  ccgaatcac  180
gccgcccag  acagtgtca  cggctctgc  gtatccaag  cagtatgca  ggccacgac  240
cacgagatc  tggggccca  gaaaaagca  ctggactac  taattcagt  cacaaatga  300
atgaatgtg  acatcccac  gttggcaga  agtttattt  aaagaacta  taatagtag  360
tgggtggtg  tcttcaaat  tctcattac  actcatcat  tgatggtgt  tggaaatga  420
cgttttatt  agtatttgg  ttcaagaaa  acgttgttt  acttaagca  ttttttgga  480
aaaagtgga  tgcaaggat  tgacatgtc  acatttatt  ggcggtata  tagatattt  540
aatgagaaa  cagtttcat  cagacaagt  gcatttgat  tcacaaaag  gaagagagg  600
gctgatgga  ttatgagaa  aatgaacac  gaaaaactc  taaaaactg  accaattat  660
cagaatcaa  tggatgcac  tcttgattt  aatgttaat  gcaatgaac  tacaaatgg  720
gtaataaat  ctgccttca  gctcctgtt  aaagatgcc  ttagactgt  tgcagcata  780
catgaagga  ttattaatt  gttggaaaa  tattttgat  tgaaaaaga  ccaatgcaa  840
gaaggtctt  acatctata  gaagttcct  actaggatg  caagaatct  agagttcct  900
aaagttgca  agcaagttg  aattgacag  ggtgatata  cagaccttt  acaggcccc  960
agcagtctt  ttgatgctt  ggaacaaca  ttagcttcc  tggaaggaa  gaaaatcaa  1020
gattctaca  ctgcaagca  ggcaactac  ctttccaat  cagtgtctt  cctggcaag  1080
actggtcta  ctctgacca  agtggatga  agggaaaag  aggcagcat  agaggaaga  1140
caggcacgt  tgaaagctt  aaaggaaca  cgcctaaaa  aacttgcaa  gaaacctca  1200
acctcttta  caactgcag  ctctcctgt  tccacctca  caggaggga  aatgactgc  1260
ccagccatt  acatatttt  tacccctag  tcttctaac  gcacatcaa  gctgcccaa  1320
gatctgctt  atttgcagc  gccaacttt  cacccatct  tacatccta  gtcaactgc  1380
tctcaggta  caagtacat  gggagatcc  ttctctgct  ctgtagatg  tgttgatga  1440
gccattcca  gcttaaatc  tttcctcac  aaaagtagt  gtgatgttc  cctttccat  1500
tcttcagat  tatctactt  tactactag  acacctact  atgaaatgt  tgttggatt  1560
actccttct  cagttgcac  gccacaccc  tcagctggc  ttaatgttg  ctttgaatc  1620
gtgtttgga  ataaatcta  aaatgttat  gtagattct  ggggctttg  tgaactagg  1680
ggacttctc  aaccaacag  ggcctctca  aaccagaac  ttcctgttg  caaactccc  1740
cctagcaag  tagtatctg  tgacttgga  tcatcttta  ccaaccttg  gggcaatct  1800
ggcatcgga  atggaacca  taagaatga  gtaaattgg  gtcaaccag  tgaaaagaa  1860
ttaactggg  gatctaact  cgaaccaaa  gttgcacca  caaccgctt  gaatgctgc  1920
acaatggca  cccctgtaa  ggcctatcc  gctactaca  caacaggca  gataggata  1980
ggaattcct  cacaaatgg  aagtgttcc  gtaatgacg  aaccaacct  aatatacag  2040
cagcctgtc  tgagacctc  aaacccctt  ggccctgta  caggagcac  gatacagtt  2100
atgtaactt  atggaagaa  atggaatta  tccaaaaag  caagtgctc  agcagcaaa  2160
tccttactt  cagcaaaat  caaactgct  tctcttaaa  ctcttaaac  ctcttcttc  2220
attaggatg  tacaagtan  tcagtgaag  cccatgaag  gaattgggg  ctagtttat  2280
gggngaacg  attcattac  gtttataaa  gccaggatt  gnttggatt  taggattan  2340
ttc  2343



<210> 825
<211> 652
<212> PRT
<213> Homo sapiens
<308> NP_009097
<400> 825

Met Ser Gly Gln Ser Leu Thr Asp Arg Ile Thr Ala Ala Gln His Ser 
  1               5                  10                  15
Val Thr Gly Ser Ala Val Ser Lys Thr Val Cys Lys Ala Thr Thr His 
             20                  25                  30
Glu Ile Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Cys 
         35                  40                  45
Thr Asn Glu Met Asn Val Asn Ile Pro Gln Leu Ala Asp Ser Leu Phe 
     50                  55                  60
Glu Arg Thr Thr Asn Ser Ser Trp Val Val Val Phe Lys Ser Leu Ile 
 65                  70                  75                  80
Thr Thr His His Leu Met Val Tyr Gly Asn Glu Arg Phe Ile Gln Tyr 
                 85                  90                  95
Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys 
             100                105                110
Ser Gly Leu Gln Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser 
         115                120                125
Arg Tyr Leu Asn Glu Lys Ala Val Ser Tyr Arg Gln Val Ala Phe Asp 
     130                135                140
Phe Thr Lys Val Lys Arg Gly Ala Asp Gly Val Met Arg Thr Met Asn 
 145                150                155                160
Thr Glu Lys Leu Leu Lys Thr Val Pro Ile Ile Gln Asn Gln Met Asp 
                 165                170                175
Ala Leu Leu Asp Phe Asn Val Asn Ser Asn Glu Leu Thr Asn Gly Val 
             180                185                190
Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Ala Ile Arg Leu Phe 
         195                200                205
Ala Ala Tyr His Glu Gly Ile Ile Asn Leu Leu Glu Lys Tyr Phe Asp 
     210                215                220
Met Lys Lys Asn Gln Cys Lys Glu Gly Leu Asp Ile Tyr Lys Lys Phe 
 225                230                235                240
Leu Thr Arg Met Thr Arg Ile Ser Glu Phe Leu Lys Val Ala Glu Gln 
                 245                250                255
Val Gly Ile Asp Arg Gly Asp Ile Pro Asp Leu Ser Gln Ala Pro Ser 
             260                265                270
Ser Leu Leu Asp Ala Leu Glu Gln His Leu Ala Ser Leu Glu Gly Lys 
         275                280                285
Lys Ile Lys Asp Ser Thr Ala Ala Ser Arg Ala Thr Thr Leu Ser Asn 
     290                295                300
Ala Val Ser Ser Leu Ala Ser Thr Gly Leu Ser Leu Thr Lys Val Asp 
 305                310                315                320
Glu Arg Glu Lys Gln Ala Ala Leu Glu Glu Glu Gln Ala Arg Leu Lys 
                 325                330                335
Ala Leu Lys Glu Gln Arg Leu Lys Glu Leu Ala Lys Lys Pro His Thr 
             340                345                350
Ser Leu Thr Thr Ala Ala Ser Pro Val Ser Thr Ser Ala Gly Gly Ile 
         355                360                365
Met Thr Ala Pro Ala Ile Asp Ile Phe Ser Thr Pro Ser Ser Ser Asn 
     370                375                380
Ser Thr Ser Lys Leu Pro Asn Asp Leu Leu Asp Leu Gln Gln Pro Thr 
 385                390                395                400
Phe His Pro Ser Val His Pro Met Ser Thr Ala Ser Gln Val Ala Ser 
                 405                410                415
Thr Trp Gly Asp Pro Phe Ser Ala Thr Val Asp Ala Val Asp Asp Ala 
             420                425                430
Ile Pro Ser Leu Asn Pro Phe Leu Thr Lys Ser Ser Gly Asp Val His 
         435                440                445
Leu Ser Ile Ser Ser Asp Val Ser Thr Phe Thr Thr Arg Thr Pro Thr 
     450                455                460
His Glu Met Phe Val Gly Phe Thr Pro Ser Pro Val Ala Gln Pro His 
 465                470                475                480
Pro Ser Ala Gly Leu Asn Val Asp Phe Glu Ser Val Phe Gly Asn Lys 
                 485                490                495
Ser Thr Asn Val Ile Val Asp Ser Gly Gly Phe Asp Glu Leu Gly Gly 
             500                505                510
Leu Leu Lys Pro Thr Val Ala Ser Gln Asn Gln Asn Leu Pro Val Ala 
         515                520                525
Lys Leu Pro Pro Ser Lys Leu Val Ser Asp Asp Leu Asp Ser Ser Leu 
     530                535                540
Ala Asn Leu Val Gly Asn Leu Gly Ile Gly Asn Gly Thr Thr Lys Asn 
 545                550                555                560
Asp Val Asn Trp Ser Gln Pro Gly Glu Lys Lys Leu Thr Gly Gly Ser 
                 565                570                575
Asn Cys Glu Pro Lys Val Ala Pro Thr Thr Ala Trp Asn Ala Ala Thr 
             580                585                590
Met Ala Pro Pro Val Met Ala Tyr Pro Ala Thr Thr Pro Thr Gly Met 
         595                600                605
Ile Gly Tyr Gly Ile Pro Pro Gln Met Gly Ser Val Pro Val Met Thr 
     610                615                620
Gln Pro Thr Leu Ile Tyr Ser Gln Pro Val Met Arg Pro Pro Asn Pro 
 625                630                635                640
Phe Gly Pro Val Ser Gly Ala Gln Ile Gln Phe Met 
                 645                650



<210> 826
<211> 1272
<212> DNA
<213> Rattus norvegicus
<308> AF045464
<400> 826

gaattcgac  gctggaacc  acgtcctct  ttaccctcc  ccttcttct  ccacctcta  60
cacggtcac  atgtcgcaa  cccggcctg  cactgtgct  ggtgccatg  agatgggtc  120
ccgcatgga  gtgacctcc  gctccgcgt  ggtgcgcgc  ttcctgcag  gcggccaca  180
ggagataga  accgccttc  tgtatgcga  cggtcagtc  gagaccatc  taggagacc  240
ggggctcgg  ctgggccgc  gcggctgca  agtaaaaat  gccaccaag  ctgccccaa  300
gtttgggaa  acactgaag  cagccgatg  tcggttcca  ctggagacg  cactgaaga  360
gctgcagtg  ccccgggtg  acctcttct  tttacactt  ccagaccac  gcactccta  420
agaggagac  ctgcaggcc  gccaccagc  gcatcagga  ggcaagttt  tggagcttg  480
tctgtccaa  tatgtctcc  gggaagtgg  tgagatttg  accctctgc  agaaaaatg  540
ctggatcat  ccaactgtg  accagggca  gtacaacgc  atcaccagg  aggtggaga  600
tgagctctt  ccctgcctc  gacacttcg  actaaggtt  tacgccttc  accctttgg  660
tgggggcct  ctgactggc  gatataaat  ccaggataa  gatgggaag  atcctgaga  720
ccgcttctt  gggaatcca  tttctcaac  gtacatgga  cgctactgg  aggaggaac  780
cttcaatgg  atcgccttg  tggagaagg  tctgaagac  acctatggc  ccactgccc  840
cagtatgat  tcagctgcc  tacggtgga  gtaccatca  tcacagctc  agggcaccc  900
aggggatgc  gtcattctg  gcatgtcca  tctggaaca  ctggagcag  acttggcct  960
ggtcgagga  gggcctctg  agccagctg  tgtggatgc  tttgaccaa  cctggaacc  1020
agttgccca  gagtgtccc  actatttcc  ctaagatac  tctgccttg  ggatggcgc  1080
gcttactgc  tgccccgcc  tgtcctggg  tcgatctga  ctggttctt  cctttttag  1140
caggtcact  tctttttct  ccctgcttt  tatacagcc  gttgctttc  aagtgagag  1200
tggctgagc  ccaatacct  ctgctgaat  aaactgttc  ctgtcacag  ctgggctac  1260
actggcggc  ga  1272



<210> 827
<211> 327
<212> PRT
<213> Rattus norvegicus
<308> P38918
<400> 827

Met Ser Gln Ala Arg Pro Ala Thr Val Leu Gly Ala Met Glu Met Gly 
  1               5                  10                  15
Arg Arg Met Asp Val Thr Ser Ser Ser Ala Ser Val Arg Ala Phe Leu 
             20                  25                  30
Gln Arg Gly His Thr Glu Ile Asp Thr Ala Phe Val Tyr Ala Asn Gly 
         35                  40                  45
Gln Ser Glu Thr Ile Leu Gly Asp Leu Gly Leu Gly Leu Gly Arg Ser 
     50                  55                  60
Gly Cys Lys Val Lys Ile Ala Thr Lys Ala Ala Pro Met Phe Gly Lys 
 65                  70                  75                  80
Thr Leu Lys Pro Ala Asp Val Arg Phe Gln Leu Glu Thr Ser Leu Lys 
                 85                  90                  95
Arg Leu Gln Cys Pro Arg Val Asp Leu Phe Tyr Leu His Phe Pro Asp 
             100                105                110
His Gly Thr Pro Ile Glu Glu Thr Leu Gln Ala Cys His His Val His 
         115                120                125
Gln Glu Gly Lys Phe Val Glu Leu Gly Leu Ser Asn Tyr Val Ser Trp 
     130                135                140
Glu Val Ala Glu Ile Cys Thr Leu Cys Lys Lys Asn Gly Trp Ile Met 
 145                150                155                160
Pro Thr Val Tyr Gln Gly Met Tyr Asn Ala Ile Thr Arg Gln Val Glu 
                 165                170                175
Thr Glu Leu Phe Pro Cys Leu Arg His Phe Gly Leu Arg Phe Tyr Ala 
             180                185                190
Phe Asn Pro Leu Ala Gly Gly Leu Leu Thr Gly Arg Tyr Lys Tyr Gln 
         195                200                205
Asp Lys Asp Gly Lys Asn Pro Glu Ser Arg Phe Phe Gly Asn Pro Phe 
     210                215                220
Ser Gln Leu Tyr Met Asp Arg Tyr Trp Lys Glu Glu His Phe Asn Gly 
 225                230                235                240
Ile Ala Leu Val Glu Lys Ala Leu Lys Thr Thr Tyr Gly Pro Thr Ala 
                 245                250                255
Pro Ser Met Ile Ser Ala Ala Val Arg Trp Met Tyr His His Ser Gln 
             260                265                270
Leu Lys Gly Thr Gln Gly Asp Ala Val Ile Leu Gly Met Ser Ser Leu 
         275                280                285
Glu Gln Leu Glu Gln Asn Leu Ala Leu Val Glu Glu Gly Pro Leu Glu 
     290                295                300
Pro Ala Val Val Asp Ala Phe Asp Gln Ala Trp Asn Leu Val Ala His 
 305                310                315                320
Glu Cys Pro Asn Tyr Phe Arg 
                 325



<210> 828
<211> 1247
<212> DNA
<213> Homo sapiens
<308> NM_012067
<400> 828

ggaattcgc  gcccgctcc  agcctggtg  ttccgaccg  tgcgcgcgg  tcctgggct  60
tcacagtct  ccgttgccg  cgtcatgtc  cggcagctg  cgcgggccc  gccagccac  120
gtgctgggc  ccatggaga  ggggcgccg  atggacgcg  ccaccagcg  cgcagtcac  180
cgcgccttc  tggagcgcg  ccacaccga  atagacacg  ccttcgtgt  cagcgacgg  240
cagtccgag  ccatccttg  cggcctggg  ctccggctg  gcggcagcg  ctgcagagt  300
aaaattgat  ccaaggcca  tccactgtt  gggaactcc  tgaagcctg  cagtctccg  360
ttccagctg  agacgtcac  gaagcggct  cagtgtccc  gagtggacc  cttctacct  420
catatgcca  accacagca  cccggtgga  gagacactg  gtgcctgcc  ccagctgca  480
caggagggc  agttcatgg  gcttggcct  tccaactat  cagcctggg  agtggccga  540
atctgtacc  tctgcaaga  caacggctg  atcctgccc  ctgtgtacc  gggcatgta  600
aatgccatc  cccggcagg  ggaaacgga  ctcttcccc  gcctcaggc  ctttggact  660
aggttctat  ccttcaacc  tctggctgg  ggcctgctg  ccggcaagt  caagtatga  720
gacaaggat  ggaaacagc  tgtgggccg  ttctttggg  atacctggg  agagatgta  780
aggaatcgc  actggaagg  gcaccactt  gagggcatt  ccctggtgg  gaaggccct  840
caggccgcg  atggcgcca  cgcccccag  atgacctcg  ccaccctcc  gtggatgta  900
caccactca  agctgcagg  tgcccacgg  gacgcggtc  tcctgggca  gtccagcct  960
gagcagctg  agcagaact  ggcagcggc  gaggaaggg  ccctggagc  ggctgtcgt  1020
gacgccttt  atcaagcct  gcatttggt  gctcacgaa  gtcccaact  cttccgcta  1080
gcccatcgt  tctcaggct  cccaaggct  ttctgtaac  tcttttgtt  ctcacattt  1140
ctttaattt  gaactgcct  agtaaattc  tagggatgg  agtntttgg  caaaaacct  1200
atagaagag  caccaccaa  tgaagaata  aactcccaa  aaaaaaa  1247



<210> 829
<211> 331
<212> PRT
<213> Homo sapiens
<308> O95154
<400> 829

Met Ser Arg Gln Leu Ser Arg Ala Arg Pro Ala Thr Val Leu Gly Ala 
  1               5                  10                  15
Met Glu Met Gly Arg Arg Met Asp Ala Pro Thr Ser Ala Ala Val Thr 
             20                  25                  30
Arg Ala Phe Leu Glu Arg Gly His Thr Glu Ile Asp Thr Ala Phe Val 
         35                  40                  45
Tyr Ser Glu Gly Gln Ser Glu Thr Ile Leu Gly Gly Leu Gly Leu Arg 
     50                  55                  60
Leu Gly Gly Ser Asp Cys Arg Val Lys Ile Asp Thr Lys Ala Ile Pro 
 65                  70                  75                  80
Leu Phe Gly Asn Ser Leu Lys Pro Asp Ser Leu Arg Phe Gln Leu Glu 
                 85                  90                  95
Thr Ser Leu Lys Arg Leu Gln Cys Pro Arg Val Asp Leu Phe Tyr Leu 
             100                105                110
His Met Pro Asp His Ser Thr Pro Val Glu Glu Thr Leu Arg Ala Cys 
         115                120                125
His Gln Leu His Gln Glu Gly Lys Phe Val Glu Leu Gly Leu Ser Asn 
     130                135                140
Tyr Ala Ala Trp Glu Val Ala Glu Ile Cys Thr Leu Cys Lys Ser Asn 
 145                150                155                160
Gly Trp Ile Leu Pro Thr Val Tyr Gln Gly Met Tyr Asn Ala Ile Thr 
                 165                170                175
Arg Gln Val Glu Thr Glu Leu Phe Pro Cys Leu Arg His Phe Gly Leu 
             180                185                190
Arg Phe Tyr Ala Phe Asn Pro Leu Ala Gly Gly Leu Leu Thr Gly Lys 
         195                200                205
Tyr Lys Tyr Glu Asp Lys Asn Gly Lys Gln Pro Val Gly Arg Phe Phe 
     210                215                220
Gly Asn Thr Trp Ala Glu Met Tyr Arg Asn Arg Tyr Trp Lys Glu His 
 225                230                235                240
His Phe Glu Gly Ile Ala Leu Val Glu Lys Ala Leu Gln Ala Ala Tyr 
                 245                250                255
Gly Ala Ser Ala Pro Ser Met Thr Ser Ala Thr Leu Arg Trp Met Tyr 
             260                265                270
His His Ser Gln Leu Gln Gly Ala His Gly Asp Ala Val Ile Leu Gly 
         275                280                285
Met Ser Ser Leu Glu Gln Leu Glu Gln Asn Leu Ala Ala Ala Glu Glu 
     290                295                300
Gly Pro Leu Glu Pro Ala Val Val Asp Ala Phe Asn Gln Ala Trp His 
 305                310                315                320
Leu Val Thr His Glu Cys Pro Asn Tyr Phe Arg 
                 325                330



<210> 830
<211> 2718
<212> DNA
<213> Rattus norvegicus
<308> AF045564
<400> 830

gaccgagtg  ctcaggctt  tgtttgccc  ttctggttc  gcaaattcc  ttctcggca  60
gatgccgga  tgctgggat  gggaacatg  cattgagac  ccttatggc  tcctgcatg  120
ggtgatccg  ggctctccc  aagggaacc  cccagccat  cttacctac  acgatgtgg  180
tctcaatca  aagctgtgc  tcaacaccc  gttcaactt  gaggacatg  aggagatca  240
caaacactt  gtggtgtgc  atgtggacg  ccctgggca  caggtggga  cgtcacagt  300
ccctcaggg  taccagttc  cctccatgg  gcagctggc  accatgctc  cgaatgtgg  360
acagcactt  ggattcaag  acgtgattg  catcggagt  ggggccgga  cgtatgtgc  420
cgccaagtt  gcactcatc  tccctgatt  ggtggaggg  ctggtgttg  tgaacattg  480
ccccaatgg  aaaggctgg  ttgattggg  tgccacgaa  ctctccggc  tgaccagca  540
tttgccaga  actgtactc  cccatctct  cagccagga  gagctggtg  acaacacgg  600
gctggtgca  agctaccgg  agcagatct  gagcgtggt  aaccaggcc  accttcagc  660
cttctggaa  atgtacaat  gccgcagag  tcttgacat  aaccggcct  ggacagtgc  720
caatgccaa  acactccgc  gcccagtga  gctggtggt  ggtgacaat  cacctgctg  780
ggacggggt  gttgagtgt  actccaaac  ggacccaac  actacaacc  tcctgaaga  840
ggcagactc  ggtggtctt  ctcaggtga  ccagccagg  aagctgact  aggccttca  900
atacttcct  cagggcatg  gctacattg  acacttgaa  gaccgaagg  tcagtggag  960
agcagtgcc  tcagccagc  tgacccgcc  tgcgcgctc  cgtaccgcg  ccctcacca  1020
cgccagttc  gtggatggt  gccgccctc  gccctgcac  cactcagac  gcagtgagg  1080
gatgggcca  gtcaaccac  ccatggagg  gtcctgctg  agtcctcgt  ctgcccaag  1140
cacccgctt  cctgccccc  ggtcccact  ccatcttcg  accggctca  cttccctct  1200
gtttatttt  gtgagagtg  aggggagga  atggggtta  ttctctttt  cttaaaacg  1260
agggatcca  cttaggacg  cgcagaaca  cagtcttag  ggatgtgaa  ggctcacct  1320
atacactcg  atctcaccg  ccaccggtt  atacggccc  cttcgtctg  ccgtctggg  1380
tgtggccag  atgtaggac  tagtacgaa  gaaagcaca  cccaccccc  ggagctggc  1440
gatagggag  ttgaagatg  caggtgctg  gccaaggct  tgttgtgag  gggagtcag  1500
ccagtgggg  gccgtccct  ttctgtaac  cttgtacca  gcacaccta  cagtagagg  1560
gacagtcat  aggacagta  ccacaagag  gcgctctga  cagtcagcc  ttttcctgg  1620
gctctctgg  caggacatg  tagaaggct  gccaggctg  agacagaat  tggagaacc  1680
tgacatggg  gcaggaacc  catactctg  caccacagg  ccatgtccc  ccctgaggc  1740
aaggtcacc  ggtctctct  gtccccgtt  gtagaggtg  aatgttgat  gctttgtat  1800
ctgtgtaca  cccctgaga  cttcatggt  gcccctttg  gagctggca  gtactgtag  1860
tccctccta  cccaggttt  aaacagcga  tgtttgtca  agtgccctg  tcgacctgg  1920
ccggcgtgt  acagacatt  ttacttgag  agtgagcat  aggaagata  aagacagaa  1980
gatacaatg  cctctgctt  ctgaagggg  tggaaatgg  ctgctcctt  tgtgggaga  2040
gggttattc  ccagatgaa  aaaggctcc  tacctccta  agcccgcaa  tatgtctgc  2100
acctgacca  gtagactct  acagcccag  gctattgtg  cagccatcc  cagagaaga  2160
agagcactt  agtgtgaat  tggggtggg  gtgatgtat  tggtgttgt  tgggtgttc  2220
gaggcagga  gacacctac  tccgtgtgt  tgtggcata  gccacccct  ctttctgta  2280
ctgtaagcc  tttccagac  gctctgaag  ccagtggag  gtatcctat  cctggttct  2340
ttcactcac  tgcttccgt  aataccgag  gtgactgtt  aaagctggc  gaattaatc  2400
cttactgta  atagcactt  aagtattgg  catcttttt  ctgtgttct  aagatatct  2460
taaatacct  tacattata  atatatgta  gtatatcgg  tccttctgt  tgtggtttc  2520
cattgatgg  tgtcttctc  ttggtcagg  tgaactttt  atggagttc  ttacttccc  2580
ctctgtaca  agttaagag  ctaattttg  gtattctgg  ggctgataa  agactttga  2640
attacaaaa  gcaaaacaa  aatccttat  gatatagaa  gatatctgt  cagaaaaac  2700
aataaagaa  ttaagcgt  2718



<210> 831
<211> 352
<212> PRT
<213> Rattus norvegicus
<308> Q9Z2L9
<400> 831

Met Pro Glu Cys Trp Asp Gly Glu His Asp Ile Glu Thr Pro Tyr Gly 
  1               5                  10                  15
Leu Leu His Val Val Ile Arg Gly Ser Pro Lys Gly Asn Arg Pro Ala 
             20                  25                  30
Ile Leu Thr Tyr His Asp Val Gly Leu Asn His Lys Leu Cys Phe Asn 
         35                  40                  45
Thr Leu Phe Asn Leu Glu Asp Met Gln Glu Ile Thr Lys His Phe Val 
     50                  55                  60
Val Cys His Val Asp Ala Pro Gly Gln Gln Val Gly Ala Ser Gln Phe 
 65                  70                  75                  80
Pro Gln Gly Tyr Gln Phe Pro Ser Met Glu Gln Leu Ala Thr Met Leu 
                 85                  90                  95
Pro Asn Val Val Gln His Phe Gly Phe Lys Tyr Val Ile Gly Ile Gly 
             100                105                110
Val Gly Ala Gly Ala Tyr Val Leu Ala Lys Phe Ala Leu Ile Phe Pro 
         115                120                125
Asp Leu Val Glu Gly Leu Val Leu Met Asn Ile Asp Pro Asn Gly Lys 
     130                135                140
Gly Trp Ile Asp Trp Ala Ala Thr Lys Leu Ser Gly Leu Thr Ser Thr 
 145                150                155                160
Leu Pro Asp Thr Val Leu Ser His Leu Phe Ser Gln Glu Glu Leu Val 
                 165                170                175
Asn Asn Thr Glu Leu Val Gln Ser Tyr Arg Gln Gln Ile Ser Ser Val 
             180                185                190
Val Asn Gln Ala Asn Leu Gln Leu Phe Trp Asn Met Tyr Asn Ser Arg 
         195                200                205
Arg Asp Leu Asp Ile Asn Arg Pro Gly Thr Val Pro Asn Ala Lys Thr 
     210                215                220
Leu Arg Cys Pro Val Met Leu Val Val Gly Asp Asn Ala Pro Ala Glu 
 225                230                235                240
Asp Gly Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Thr Thr Thr 
                 245                250                255
Phe Leu Lys Met Ala Asp Ser Gly Gly Leu Pro Gln Val Thr Gln Pro 
             260                265                270
Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr 
         275                280                285
Ile Ala His Leu Lys Asp Arg Arg Leu Ser Gly Gly Ala Val Pro Ser 
     290                295                300
Ala Ser Met Thr Arg Leu Ala Arg Ser Arg Thr Ala Ser Leu Thr Ser 
 305                310                315                320
Ala Ser Ser Val Asp Gly Ser Arg Pro Gln Pro Cys Thr His Ser Asp 
                 325                330                335
Ser Ser Glu Gly Met Gly Gln Val Asn His Thr Met Glu Val Ser Cys 
             340                345                350



<210> 832
<211> 2994
<212> DNA
<213> Homo sapiens
<308> AB033006
<400> 832

ctcccactc  agctgcccc  gccctctgg  cccgagtga  tcaggcctt  gtttgtcct  60
cctggtaga  gcgggttcc  tccctcggc  agatgccgg  gtgctggga  ggggaacat  120
acatcgaga  accctacgg  cttctgcat  tagtgatcc  gggctcccc  aaggggaac  180
gcccagcca  cctcaccta  catgatgtg  gcctcaacc  caaactatg  ttcaacacc  240
tcttcaact  cgaggacat  caggagatc  ccaagcact  tgtggtgtg  cacgtggat  300
cccctggac  acaggtggg  gcgtcgcag  ttcctcagg  gtaccagtt  ccctccatg  360
agcagctgg  tgccatgct  cccagcgtg  tgcagcatt  cgggttcaa  tatgtgatt  420
gcatcggag  gggcgccgg  gcctatgtg  tggccaagt  tgcactcat  ttccccgac  480
tggtggagg  gctggtgct  gtgaacatc  accccaatg  caaaggctg  atagactgg  540
ctgccacca  gctctccgg  ctaactagc  ctttacccg  cacggtgct  tcccacctc  600
tcagccagg  ggagctggt  aacaacaca  agttggtgc  gagctaccg  cagcagatt  660
ggaacgtgg  gaaccaggc  aacctgcag  tcttctgga  catgtacaa  agccgcaga  720
acctggaca  taaccggcc  ggaacggtg  ccaatgcca  gacgctccg  tgccccgtg  780
tgctggtgg  tggggataa  gcacccgct  aggacgggg  ggtggagtg  aactccaaa  840
tggacccga  cactacaac  ttcctgaag  tggcagact  tggagggct  ccccaggtc  900
cacagccag  gaagctgac  gaagccttc  aatacttcc  gcaaggcat  ggctacatt  960
cgtacttga  ggaccgaag  ctgagtgga  gagcagtgc  ctcagccag  atgacccgc  1020
tggcacgct  ccgcactgc  tccctcacc  gtgccagct  ggtggatgg  agccgccca  1080
aggcctgca  ccactcgga  agcagcgag  ggctgggcc  ggtcaacca  accatggag  1140
tgtcctgtt  aagcccttg  tcccgctga  gacgcccac  tcgaggccc  accgccatc  1200
ttgcgccgg  tcatgttcc  tttagttta  ttttgtgag  gcaaagggg  ggaaatggg  1260
ttctgtttg  aaaaaatga  gggatctta  atgctgcag  agaacagtc  ccaggtgtt  1320
taaggggct  agtcctcct  atcccatct  actctccgt  gtaacttag  caacttgac  1380
cctctcatc  cactcccgg  ggcccaggc  cagaagggc  gggccatag  gagggagat  1440
cgctacgga  ccaggtcat  cctgggtga  cccttgggc  ggcatgttt  gagatgaga  1500
aggcttcga  agggtgggt  ctgggccac  ggggtgcgg  gccagctca  gcactggcg  1560
gggagccct  ggagacccc  tcccccacc  tccaccaag  acacctgtt  ctgtctcat  1620
gcacatgtg  caatcatct  gacaacagc  acaaggggg  gctcggacc  ggcagccac  1680
ttcctggtg  tctctgggc  cagctggtg  tgtagggcc  cgcaggcag  ggcgtcaag  1740
ggtttctct  cccaaggaa  acagaacat  gagaaccgt  agggcagga  ccccacaga  1800
tgtcccttc  agcccacac  ctgccacct  ctggccctg  cccaattct  agccaaggc  1860
tccccgagg  agaagttgc  tggtcctct  tccccacag  gacctgact  ggggtgagg  1920
agaaggagg  gagagccca  gtgtggtgt  tgtgcccct  agaactttg  ggtgactgc  1980
tttgggagc  cgcaggtgg  cagaggcag  ggtagctga  ttcctggag  ccccttttt  2040
gcccccagg  tccccagag  gcaacgcca  cagtagcag  gtggtgttt  aggcagagc  2100
ctggccagg  tgtgccagt  tgtcccgga  gcatcacta  ggaagagag  gtttattta  2160
tcaactggc  caaggcagc  aggcttcta  agtcccaca  cccatagcc  cctgggctg  2220
ggcttactg  gggctgaag  ttctggaca  gaacaaggg  caggtagaa  agaaaggct  2280
cccctacac  ccagcctcc  gctgtcccc  gaagcccag  actgcgttg  atgctttcc  2340
tccactcac  ttaccccat  gcatcttgc  gcccagaaa  cagagccat  tgtctcaga  2400
cctaaatca  taatcacaa  ccccaaaac  ggagagagc  gtgaaaaca  gcagggctg  2460
ggacggggg  agggttgtg  cgggtgttc  gaggctgag  ggacaccta  atgcgtatt  2520
cctctacac  catcacccc  cttctataa  cttaagcca  gactagcct  gtggcgtgt  2580
agtttctgc  cagttctac  ccctcatgt  cttcttctg  atactgaat  tgactgttt  2640
aaagctggt  gaattcatc  ctcttactg  agataacac  gcaaatctt  gaattttgt  2700
ttttgctgt  tccagatgt  tctataaat  tctatacat  atatgtgtg  gtgtgtgtg  2760
gtgtgtgtg  gtgtgtgta  atcgggtcc  cccatgtgt  gtgttcttc  ggaggttgt  2820
tctttggtc  aggtgaact  ttaatgttt  ttattttct  ctccgcaca  agtaaagag  2880
ctaattttg  gtattctgg  ggctgctgt  atgagatga  aaaatgtaa  acaaaactc  2940
agtcaacgt  gaaagagtt  actgtgctg  aaaactaat  aagaaccta  gaag  2994



<210> 833
<211> 352
<212> PRT
<213> Homo sapiens
<308> Q9ULP0
<400> 833

Met Pro Glu Cys Trp Asp Gly Glu His Asp Ile Glu Thr Pro Tyr Gly 
  1               5                  10                  15
Leu Leu His Val Val Ile Arg Gly Ser Pro Lys Gly Asn Arg Pro Ala 
             20                  25                  30
Ile Leu Thr Tyr His Asp Val Gly Leu Asn His Lys Leu Cys Phe Asn 
         35                  40                  45
Thr Phe Phe Asn Phe Glu Asp Met Gln Glu Ile Thr Lys His Phe Val 
     50                  55                  60
Val Cys His Val Asp Ala Pro Gly Gln Gln Val Gly Ala Ser Gln Phe 
 65                  70                  75                  80
Pro Gln Gly Tyr Gln Phe Pro Ser Met Glu Gln Leu Ala Ala Met Leu 
                 85                  90                  95
Pro Ser Val Val Gln His Phe Gly Phe Lys Tyr Val Ile Gly Ile Gly 
             100                105                110
Val Gly Ala Gly Ala Tyr Val Leu Ala Lys Phe Ala Leu Ile Phe Pro 
         115                120                125
Asp Leu Val Glu Gly Leu Val Leu Val Asn Ile Asp Pro Asn Gly Lys 
     130                135                140
Gly Trp Ile Asp Trp Ala Ala Thr Lys Leu Ser Gly Leu Thr Ser Thr 
 145                150                155                160
Leu Pro Asp Thr Val Leu Ser His Leu Phe Ser Gln Glu Glu Leu Val 
                 165                170                175
Asn Asn Thr Glu Leu Val Gln Ser Tyr Arg Gln Gln Ile Gly Asn Val 
             180                185                190
Val Asn Gln Ala Asn Leu Gln Leu Phe Trp Asn Met Tyr Asn Ser Arg 
         195                200                205
Arg Asp Leu Asp Ile Asn Arg Pro Gly Thr Val Pro Asn Ala Lys Thr 
     210                215                220
Leu Arg Cys Pro Val Met Leu Val Val Gly Asp Asn Ala Pro Ala Glu 
 225                230                235                240
Asp Gly Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Thr Thr Thr 
                 245                250                255
Phe Leu Lys Met Ala Asp Ser Gly Gly Leu Pro Gln Val Thr Gln Pro 
             260                265                270
Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr 
         275                280                285
Ile Ala Tyr Leu Lys Asp Arg Arg Leu Ser Gly Gly Ala Val Pro Ser 
     290                295                300
Ala Ser Met Thr Arg Leu Ala Arg Ser Arg Thr Ala Ser Leu Thr Ser 
 305                310                315                320
Ala Ser Ser Val Asp Gly Ser Arg Pro Gln Ala Cys Thr His Ser Glu 
                 325                330                335
Ser Ser Glu Gly Leu Gly Gln Val Asn His Thr Met Glu Val Ser Cys 
             340                345                350



<210> 834
<211> 2718
<212> DNA
<213> Rattus norvegicus
<308> AF045564
<400> 834

gaccgagtg  ctcaggctt  tgtttgccc  ttctggttc  gcaaattcc  ttctcggca  60
gatgccgga  tgctgggat  gggaacatg  cattgagac  ccttatggc  tcctgcatg  120
ggtgatccg  ggctctccc  aagggaacc  cccagccat  cttacctac  acgatgtgg  180
tctcaatca  aagctgtgc  tcaacaccc  gttcaactt  gaggacatg  aggagatca  240
caaacactt  gtggtgtgc  atgtggacg  ccctgggca  caggtggga  cgtcacagt  300
ccctcaggg  taccagttc  cctccatgg  gcagctggc  accatgctc  cgaatgtgg  360
acagcactt  ggattcaag  acgtgattg  catcggagt  ggggccgga  cgtatgtgc  420
cgccaagtt  gcactcatc  tccctgatt  ggtggaggg  ctggtgttg  tgaacattg  480
ccccaatgg  aaaggctgg  ttgattggg  tgccacgaa  ctctccggc  tgaccagca  540
tttgccaga  actgtactc  cccatctct  cagccagga  gagctggtg  acaacacgg  600
gctggtgca  agctaccgg  agcagatct  gagcgtggt  aaccaggcc  accttcagc  660
cttctggaa  atgtacaat  gccgcagag  tcttgacat  aaccggcct  ggacagtgc  720
caatgccaa  acactccgc  gcccagtga  gctggtggt  ggtgacaat  cacctgctg  780
ggacggggt  gttgagtgt  actccaaac  ggacccaac  actacaacc  tcctgaaga  840
ggcagactc  ggtggtctt  ctcaggtga  ccagccagg  aagctgact  aggccttca  900
atacttcct  cagggcatg  gctacattg  acacttgaa  gaccgaagg  tcagtggag  960
agcagtgcc  tcagccagc  tgacccgcc  tgcgcgctc  cgtaccgcg  ccctcacca  1020
cgccagttc  gtggatggt  gccgccctc  gccctgcac  cactcagac  gcagtgagg  1080
gatgggcca  gtcaaccac  ccatggagg  gtcctgctg  agtcctcgt  ctgcccaag  1140
cacccgctt  cctgccccc  ggtcccact  ccatcttcg  accggctca  cttccctct  1200
gtttatttt  gtgagagtg  aggggagga  atggggtta  ttctctttt  cttaaaacg  1260
agggatcca  cttaggacg  cgcagaaca  cagtcttag  ggatgtgaa  ggctcacct  1320
atacactcg  atctcaccg  ccaccggtt  atacggccc  cttcgtctg  ccgtctggg  1380
tgtggccag  atgtaggac  tagtacgaa  gaaagcaca  cccaccccc  ggagctggc  1440
gatagggag  ttgaagatg  caggtgctg  gccaaggct  tgttgtgag  gggagtcag  1500
ccagtgggg  gccgtccct  ttctgtaac  cttgtacca  gcacaccta  cagtagagg  1560
gacagtcat  aggacagta  ccacaagag  gcgctctga  cagtcagcc  ttttcctgg  1620
gctctctgg  caggacatg  tagaaggct  gccaggctg  agacagaat  tggagaacc  1680
tgacatggg  gcaggaacc  catactctg  caccacagg  ccatgtccc  ccctgaggc  1740
aaggtcacc  ggtctctct  gtccccgtt  gtagaggtg  aatgttgat  gctttgtat  1800
ctgtgtaca  cccctgaga  cttcatggt  gcccctttg  gagctggca  gtactgtag  1860
tccctccta  cccaggttt  aaacagcga  tgtttgtca  agtgccctg  tcgacctgg  1920
ccggcgtgt  acagacatt  ttacttgag  agtgagcat  aggaagata  aagacagaa  1980
gatacaatg  cctctgctt  ctgaagggg  tggaaatgg  ctgctcctt  tgtgggaga  2040
gggttattc  ccagatgaa  aaaggctcc  tacctccta  agcccgcaa  tatgtctgc  2100
acctgacca  gtagactct  acagcccag  gctattgtg  cagccatcc  cagagaaga  2160
agagcactt  agtgtgaat  tggggtggg  gtgatgtat  tggtgttgt  tgggtgttc  2220
gaggcagga  gacacctac  tccgtgtgt  tgtggcata  gccacccct  ctttctgta  2280
ctgtaagcc  tttccagac  gctctgaag  ccagtggag  gtatcctat  cctggttct  2340
ttcactcac  tgcttccgt  aataccgag  gtgactgtt  aaagctggc  gaattaatc  2400
cttactgta  atagcactt  aagtattgg  catcttttt  ctgtgttct  aagatatct  2460
taaatacct  tacattata  atatatgta  gtatatcgg  tccttctgt  tgtggtttc  2520
cattgatgg  tgtcttctc  ttggtcagg  tgaactttt  atggagttc  ttacttccc  2580
ctctgtaca  agttaagag  ctaattttg  gtattctgg  ggctgataa  agactttga  2640
attacaaaa  gcaaaacaa  aatccttat  gatatagaa  gatatctgt  cagaaaaac  2700
aataaagaa  ttaagcgt  2718



<210> 835
<211> 352
<212> PRT
<213> Rattus norvegicus
<308> Q9Z2L9
<400> 835

Met Pro Glu Cys Trp Asp Gly Glu His Asp Ile Glu Thr Pro Tyr Gly 
  1               5                  10                  15
Leu Leu His Val Val Ile Arg Gly Ser Pro Lys Gly Asn Arg Pro Ala 
             20                  25                  30
Ile Leu Thr Tyr His Asp Val Gly Leu Asn His Lys Leu Cys Phe Asn 
         35                  40                  45
Thr Leu Phe Asn Leu Glu Asp Met Gln Glu Ile Thr Lys His Phe Val 
     50                  55                  60
Val Cys His Val Asp Ala Pro Gly Gln Gln Val Gly Ala Ser Gln Phe 
 65                  70                  75                  80
Pro Gln Gly Tyr Gln Phe Pro Ser Met Glu Gln Leu Ala Thr Met Leu 
                 85                  90                  95
Pro Asn Val Val Gln His Phe Gly Phe Lys Tyr Val Ile Gly Ile Gly 
             100                105                110
Val Gly Ala Gly Ala Tyr Val Leu Ala Lys Phe Ala Leu Ile Phe Pro 
         115                120                125
Asp Leu Val Glu Gly Leu Val Leu Met Asn Ile Asp Pro Asn Gly Lys 
     130                135                140
Gly Trp Ile Asp Trp Ala Ala Thr Lys Leu Ser Gly Leu Thr Ser Thr 
 145                150                155                160
Leu Pro Asp Thr Val Leu Ser His Leu Phe Ser Gln Glu Glu Leu Val 
                 165                170                175
Asn Asn Thr Glu Leu Val Gln Ser Tyr Arg Gln Gln Ile Ser Ser Val 
             180                185                190
Val Asn Gln Ala Asn Leu Gln Leu Phe Trp Asn Met Tyr Asn Ser Arg 
         195                200                205
Arg Asp Leu Asp Ile Asn Arg Pro Gly Thr Val Pro Asn Ala Lys Thr 
     210                215                220
Leu Arg Cys Pro Val Met Leu Val Val Gly Asp Asn Ala Pro Ala Glu 
 225                230                235                240
Asp Gly Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Thr Thr Thr 
                 245                250                255
Phe Leu Lys Met Ala Asp Ser Gly Gly Leu Pro Gln Val Thr Gln Pro 
             260                265                270
Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr 
         275                280                285
Ile Ala His Leu Lys Asp Arg Arg Leu Ser Gly Gly Ala Val Pro Ser 
     290                295                300
Ala Ser Met Thr Arg Leu Ala Arg Ser Arg Thr Ala Ser Leu Thr Ser 
 305                310                315                320
Ala Ser Ser Val Asp Gly Ser Arg Pro Gln Pro Cys Thr His Ser Asp 
                 325                330                335
Ser Ser Glu Gly Met Gly Gln Val Asn His Thr Met Glu Val Ser Cys 
             340                345                350



<210> 836
<211> 2994
<212> DNA
<213> Homo sapiens
<308> AB033006
<400> 836

ctcccactc  agctgcccc  gccctctgg  cccgagtga  tcaggcctt  gtttgtcct  60
cctggtaga  gcgggttcc  tccctcggc  agatgccgg  gtgctggga  ggggaacat  120
acatcgaga  accctacgg  cttctgcat  tagtgatcc  gggctcccc  aaggggaac  180
gcccagcca  cctcaccta  catgatgtg  gcctcaacc  caaactatg  ttcaacacc  240
tcttcaact  cgaggacat  caggagatc  ccaagcact  tgtggtgtg  cacgtggat  300
cccctggac  acaggtggg  gcgtcgcag  ttcctcagg  gtaccagtt  ccctccatg  360
agcagctgg  tgccatgct  cccagcgtg  tgcagcatt  cgggttcaa  tatgtgatt  420
gcatcggag  gggcgccgg  gcctatgtg  tggccaagt  tgcactcat  ttccccgac  480
tggtggagg  gctggtgct  gtgaacatc  accccaatg  caaaggctg  atagactgg  540
ctgccacca  gctctccgg  ctaactagc  ctttacccg  cacggtgct  tcccacctc  600
tcagccagg  ggagctggt  aacaacaca  agttggtgc  gagctaccg  cagcagatt  660
ggaacgtgg  gaaccaggc  aacctgcag  tcttctgga  catgtacaa  agccgcaga  720
acctggaca  taaccggcc  ggaacggtg  ccaatgcca  gacgctccg  tgccccgtg  780
tgctggtgg  tggggataa  gcacccgct  aggacgggg  ggtggagtg  aactccaaa  840
tggacccga  cactacaac  ttcctgaag  tggcagact  tggagggct  ccccaggtc  900
cacagccag  gaagctgac  gaagccttc  aatacttcc  gcaaggcat  ggctacatt  960
cgtacttga  ggaccgaag  ctgagtgga  gagcagtgc  ctcagccag  atgacccgc  1020
tggcacgct  ccgcactgc  tccctcacc  gtgccagct  ggtggatgg  agccgccca  1080
aggcctgca  ccactcgga  agcagcgag  ggctgggcc  ggtcaacca  accatggag  1140
tgtcctgtt  aagcccttg  tcccgctga  gacgcccac  tcgaggccc  accgccatc  1200
ttgcgccgg  tcatgttcc  tttagttta  ttttgtgag  gcaaagggg  ggaaatggg  1260
ttctgtttg  aaaaaatga  gggatctta  atgctgcag  agaacagtc  ccaggtgtt  1320
taaggggct  agtcctcct  atcccatct  actctccgt  gtaacttag  caacttgac  1380
cctctcatc  cactcccgg  ggcccaggc  cagaagggc  gggccatag  gagggagat  1440
cgctacgga  ccaggtcat  cctgggtga  cccttgggc  ggcatgttt  gagatgaga  1500
aggcttcga  agggtgggt  ctgggccac  ggggtgcgg  gccagctca  gcactggcg  1560
gggagccct  ggagacccc  tcccccacc  tccaccaag  acacctgtt  ctgtctcat  1620
gcacatgtg  caatcatct  gacaacagc  acaaggggg  gctcggacc  ggcagccac  1680
ttcctggtg  tctctgggc  cagctggtg  tgtagggcc  cgcaggcag  ggcgtcaag  1740
ggtttctct  cccaaggaa  acagaacat  gagaaccgt  agggcagga  ccccacaga  1800
tgtcccttc  agcccacac  ctgccacct  ctggccctg  cccaattct  agccaaggc  1860
tccccgagg  agaagttgc  tggtcctct  tccccacag  gacctgact  ggggtgagg  1920
agaaggagg  gagagccca  gtgtggtgt  tgtgcccct  agaactttg  ggtgactgc  1980
tttgggagc  cgcaggtgg  cagaggcag  ggtagctga  ttcctggag  ccccttttt  2040
gcccccagg  tccccagag  gcaacgcca  cagtagcag  gtggtgttt  aggcagagc  2100
ctggccagg  tgtgccagt  tgtcccgga  gcatcacta  ggaagagag  gtttattta  2160
tcaactggc  caaggcagc  aggcttcta  agtcccaca  cccatagcc  cctgggctg  2220
ggcttactg  gggctgaag  ttctggaca  gaacaaggg  caggtagaa  agaaaggct  2280
cccctacac  ccagcctcc  gctgtcccc  gaagcccag  actgcgttg  atgctttcc  2340
tccactcac  ttaccccat  gcatcttgc  gcccagaaa  cagagccat  tgtctcaga  2400
cctaaatca  taatcacaa  ccccaaaac  ggagagagc  gtgaaaaca  gcagggctg  2460
ggacggggg  agggttgtg  cgggtgttc  gaggctgag  ggacaccta  atgcgtatt  2520
cctctacac  catcacccc  cttctataa  cttaagcca  gactagcct  gtggcgtgt  2580
agtttctgc  cagttctac  ccctcatgt  cttcttctg  atactgaat  tgactgttt  2640
aaagctggt  gaattcatc  ctcttactg  agataacac  gcaaatctt  gaattttgt  2700
ttttgctgt  tccagatgt  tctataaat  tctatacat  atatgtgtg  gtgtgtgtg  2760
gtgtgtgtg  gtgtgtgta  atcgggtcc  cccatgtgt  gtgttcttc  ggaggttgt  2820
tctttggtc  aggtgaact  ttaatgttt  ttattttct  ctccgcaca  agtaaagag  2880
ctaattttg  gtattctgg  ggctgctgt  atgagatga  aaaatgtaa  acaaaactc  2940
agtcaacgt  gaaagagtt  actgtgctg  aaaactaat  aagaaccta  gaag  2994



<210> 837
<211> 352
<212> PRT
<213> Homo sapiens
<308> Q9ULP0
<400> 837

Met Pro Glu Cys Trp Asp Gly Glu His Asp Ile Glu Thr Pro Tyr Gly 
  1               5                  10                  15
Leu Leu His Val Val Ile Arg Gly Ser Pro Lys Gly Asn Arg Pro Ala 
             20                  25                  30
Ile Leu Thr Tyr His Asp Val Gly Leu Asn His Lys Leu Cys Phe Asn 
         35                  40                  45
Thr Phe Phe Asn Phe Glu Asp Met Gln Glu Ile Thr Lys His Phe Val 
     50                  55                  60
Val Cys His Val Asp Ala Pro Gly Gln Gln Val Gly Ala Ser Gln Phe 
 65                  70                  75                  80
Pro Gln Gly Tyr Gln Phe Pro Ser Met Glu Gln Leu Ala Ala Met Leu 
                 85                  90                  95
Pro Ser Val Val Gln His Phe Gly Phe Lys Tyr Val Ile Gly Ile Gly 
             100                105                110
Val Gly Ala Gly Ala Tyr Val Leu Ala Lys Phe Ala Leu Ile Phe Pro 
         115                120                125
Asp Leu Val Glu Gly Leu Val Leu Val Asn Ile Asp Pro Asn Gly Lys 
     130                135                140
Gly Trp Ile Asp Trp Ala Ala Thr Lys Leu Ser Gly Leu Thr Ser Thr 
 145                150                155                160
Leu Pro Asp Thr Val Leu Ser His Leu Phe Ser Gln Glu Glu Leu Val 
                 165                170                175
Asn Asn Thr Glu Leu Val Gln Ser Tyr Arg Gln Gln Ile Gly Asn Val 
             180                185                190
Val Asn Gln Ala Asn Leu Gln Leu Phe Trp Asn Met Tyr Asn Ser Arg 
         195                200                205
Arg Asp Leu Asp Ile Asn Arg Pro Gly Thr Val Pro Asn Ala Lys Thr 
     210                215                220
Leu Arg Cys Pro Val Met Leu Val Val Gly Asp Asn Ala Pro Ala Glu 
 225                230                235                240
Asp Gly Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Thr Thr Thr 
                 245                250                255
Phe Leu Lys Met Ala Asp Ser Gly Gly Leu Pro Gln Val Thr Gln Pro 
             260                265                270
Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr 
         275                280                285
Ile Ala Tyr Leu Lys Asp Arg Arg Leu Ser Gly Gly Ala Val Pro Ser 
     290                295                300
Ala Ser Met Thr Arg Leu Ala Arg Ser Arg Thr Ala Ser Leu Thr Ser 
 305                310                315                320
Ala Ser Ser Val Asp Gly Ser Arg Pro Gln Ala Cys Thr His Ser Glu 
                 325                330                335
Ser Ser Glu Gly Leu Gly Gln Val Asn His Thr Met Glu Val Ser Cys 
             340                345                350



<210> 838
<211> 2611
<212> DNA
<213> Rattus norvegicus
<308> AF047707
<400> 838

atacgactc  ctatagggc  cgagcggtc  cccgggcag  tagcggccg  tgaattcta  60
aacagcggg  cgggggatg  cgctgctgg  cctggccca  gagggaatg  ccttgttcg  120
cttcgtgct  ttcgtggtg  tgtggctga  gcatttcat  tccatcatc  acacccggt  180
acacctcaa  aagaaggca  cagacaaac  gccgtacag  aagctccct  gagtctctc  240
tctgaaacc  ctgaagggg  tggacccta  cctaatcaa  aacttggag  cattctttg  300
actggatta  cccaaatat  aagtactcc  ttgtgtaca  gatcatgat  atccagcca  360
tgaggtgtg  aagaaactg  ttggaaaat  cccaaacgt  gatgctaga  tatttatag  420
tggtaaaaa  gttggcatt  atcctaaaa  taataattt  atgccagca  atgaagttg  480
aaagtatga  ctcatatgg  tttgtgata  cggaatacg  gtcattcca  acacattaa  540
tgacatggt  aatcagatg  cggagagag  ggggctggt  cacgggctt  catacgtag  600
tgacagaca  ggctttgct  ccaccttag  gcaggtata  tttggaact  cacacccaa  660
atcctatat  tctgccaat  tgaccggct  caagtgtgt  acggggatg  cttgcttga  720
gaggaagga  gtgctagat  aggcaggag  gctcatagc  tttgctcag  acattgcgg  780
agattactt  atggccaaa  caatagcgg  ccgaggctg  aagttttca  tgtctacgc  840
agttgccat  caaaactct  gttcatact  catttctca  tttcaatcc  gaatgatca  900
gtggaccaa  ttgaggatt  acatgcttc  tgccacaat  atttgtgag  caatttcag  960
atgctttgt  gccagttta  ttatcgggt  ggcagccca  cacgtgttc  gatgggata  1020
catggtttt  ttcatgtgt  actgcctgg  atggtttat  tttgactac  ttcaactca  1080
gggtgtcca  ggtggcaca  tatgctttt  aaaacttga  tatgctgtg  cttggttca  1140
ccgcgaatc  atgacaata  acattttct  gtcggcact  tgggaccct  ctataagct  1200
gagagccgg  cgctacagg  tgcgctgtg  agggacggc  gaggagatc  tggatgtgt  1260
acaaggcct  tgtggccga  tggacagga  ggaatggaa  tgttataga  tatgtttat  1320
gagactttc  aggacctgc  ttcagtggc  catccgtgt  tgtgtggta  ccgctcttt  1380
atttattcg  atggccctt  catctgtga  aagcaaaaa  acaaaagca  aacatgtct  1440
tagtcgtgg  caaacagtg  attttatgg  ggtagagaa  caagacaat  ggttctagg  1500
agtgggttt  gttgttgtt  attttttta  acaaatata  atatatatc  atcaataca  1560
acacacaca  acacacaca  acacacacg  ctgctctgc  gcagacact  tgacagtat  1620
cttcagtag  gaaagtttc  tacctgagt  actcactct  aggtccgca  gggcagaac  1680
gcagctctg  gagagggaa  gggcaggtg  tggccgccc  tgtgtgaag  gaatgggtt  1740
tacagggag  cgctgactg  gaaactttt  catgcttta  gcctacctc  tgtagttgt  1800
gcagagcaa  tagaagtta  aagttgtga  atggtagct  ggccttgca  aaacaaatg  1860
gaaacttta  taataaaag  gccgagtct  gtatttata  aaatctgtg  ggttttttt  1920
gttttgttt  tttgttttt  ttttgtttt  ttttatttt  tggtctcat  gcaatgaac  1980
aaaagtggt  gagattggt  tttagtggt  accatgaat  gaaggcatc  tttggacca  2040
ctgttgttg  ttctgtctt  aaccatatt  atcactgtg  tgtaattag  agagctgaa  2100
ctttccttc  ctgctcctc  cccagcccg  cccatcttt  cattaatat  cattctctc  2160
ctctctccc  ctctccctc  ctccttctc  ctctctccc  ccctctctc  ctctctctc  2220
ctctctctc  ccttctctc  ctctctctc  ctctctctc  ttctcgcct  atgatgaat  2280
tgtttgaag  gcattttct  cgtgagcaa  ggcttggat  catattcca  tttttattt  2340
tttttctgt  aaatgggta  tattacccc  tgaggaaaa  ttgcacagt  agaaccagt  2400
tagttatga  ccactacat  tttattttt  tacattact  tctcacgag  tgagttttg  2460
tgagtgcgt  tgtcggttt  tttagtggc  tttggtgga  gcccttctt  gcgctgctg  2520
agtgaaatc  tgctgacta  ttagctttt  tgttgatct  agtatgggc  aagaaacaa  2580
atccaaatg  ctggacaga  ttctgtaaa  a  2611



<210> 839
<211> 394
<212> PRT
<213> Rattus norvegicus
<308> AAD02464
<400> 839

Met Ala Leu Leu Asp Leu Ala Gln Glu Gly Met Ala Leu Phe Gly Phe 
  1               5                  10                  15
Val Leu Phe Val Val Leu Trp Leu Met His Phe Met Ser Ile Ile Tyr 
             20                  25                  30
Thr Arg Leu His Leu Asn Lys Lys Ala Thr Asp Lys Gln Pro Tyr Ser 
         35                  40                  45
Lys Leu Pro Gly Val Ser Leu Leu Lys Pro Leu Lys Gly Val Asp Pro 
     50                  55                  60
Asn Leu Ile Asn Asn Leu Glu Thr Phe Phe Glu Leu Asp Tyr Pro Lys 
 65                  70                  75                  80
Tyr Glu Val Leu Leu Cys Val Gln Asp His Asp Asp Pro Ala Ile Glu 
                 85                  90                  95
Val Cys Lys Lys Leu Leu Gly Lys Tyr Pro Asn Val Asp Ala Arg Leu 
             100                105                110
Phe Ile Gly Gly Lys Lys Val Gly Ile Asn Pro Lys Ile Asn Asn Leu 
         115                120                125
Met Pro Ala Tyr Glu Val Ala Lys Tyr Asp Leu Ile Trp Ile Cys Asp 
     130                135                140
Ser Gly Ile Arg Val Ile Pro Asp Thr Leu Thr Asp Met Val Asn Gln 
 145                150                155                160
Met Thr Glu Arg Val Gly Leu Val His Gly Leu Pro Tyr Val Ala Asp 
                 165                170                175
Arg Gln Gly Phe Ala Ala Thr Leu Glu Gln Val Tyr Phe Gly Thr Ser 
             180                185                190
His Pro Arg Ser Tyr Ile Ser Ala Asn Val Thr Gly Phe Lys Cys Val 
         195                200                205
Thr Gly Met Ser Cys Leu Met Arg Lys Asp Val Leu Asp Gln Ala Gly 
     210                215                220
Gly Leu Ile Ala Phe Ala Gln Tyr Ile Ala Glu Asp Tyr Phe Met Ala 
 225                230                235                240
Lys Ala Ile Ala Asp Arg Gly Trp Lys Phe Ser Met Ser Thr Gln Val 
                 245                250                255
Ala Met Gln Asn Ser Gly Ser Tyr Ser Ile Ser Gln Phe Gln Ser Arg 
             260                265                270
Met Ile Arg Trp Thr Lys Leu Arg Ile Asn Met Leu Pro Ala Thr Ile 
         275                280                285
Ile Cys Glu Pro Ile Ser Glu Cys Phe Val Ala Ser Leu Ile Ile Gly 
     290                295                300
Trp Ala Ala His His Val Phe Arg Trp Asp Ile Met Val Phe Phe Met 
 305                310                315                320
Cys His Cys Leu Ala Trp Phe Ile Phe Asp Tyr Ile Gln Leu Arg Gly 
                 325                330                335
Val Gln Gly Gly Thr Leu Cys Phe Ser Lys Leu Asp Tyr Ala Val Ala 
             340                345                350
Trp Phe Ile Arg Glu Ser Met Thr Ile Tyr Ile Phe Leu Ser Ala Leu 
         355                360                365
Trp Asp Pro Thr Ile Ser Trp Arg Ala Gly Arg Tyr Arg Leu Arg Cys 
     370                375                380
Gly Gly Thr Ala Glu Glu Ile Leu Asp Val 
 385                390



<210> 840
<211> 1637
<212> DNA
<213> Homo sapiens
<308> D50840
<400> 840

gaggcgaac  ggagcgcgg  gccgcggtc  ccccgacca  agccgggag  ccgcagcac  60
cgcagccgc  cgcgagcgc  ccgaagaca  cgcgcaggc  agagcgcgc  ggcgggggc  120
cgcaggccc  gcccgcccc  tccgtcccc  cccccctcc  ccctttcct  tccccacct  180
cctctcgcc  cccgcgccc  cgcaccggg  gcccaccct  tcctcctcc  gcgggagcg  240
tgtccgtgt  ggcggccgc  gcgggccgg  ccggtccgg  gggccgggg  atggcgctg  300
tggacctgg  cttggaggg  atggccgtc  tcgggttcg  cctcttctt  gtgctgtgg  360
tgatgcatt  catggctat  atctacacc  gattacacc  caacaagaa  gcaactgac  420
aacagcctt  tagcaagct  ccaggtgtc  ctcttctga  accactgaa  ggggtagat  480
ctaacttaa  caacaacct  gaaacattc  ttgaattgg  ttatcccaa  tatgaagtg  540
tcctttgtg  acaagatca  gatgatcca  ccattgatg  atgtaagaa  cttcttgga  600
aatatccaa  tgttgatgc  agattgttt  taggtggta  aaaagttgg  attaatcct  660
aaattaata  tttaatgcc  ggatatgaa  ttgcaaagt  tgatcttat  tggatttgt  720
atagtggaa  aagagtaat  ccagatacg  ttactgaca  ggtgaatca  atgacagaa  780
aagtaggct  ggttcacgg  ctgccttac  tagcagaca  acagggctt  gctgccacc  840
tagagcagg  atattttgg  acttcacat  caagatact  tatctctgc  aatgtaact  900
gtttcaaat  tgtgacagg  atgtcttgt  taatgagaa  agatgtgtt  gatcaagca  960
gaggactta  agcttttgc  cagtacatt  ccgaagatt  ctttatggc  aaagcgata  1020
ctgaccgag  ttggaggtt  gcaatgtcc  ctcaagttg  aatgcaaaa  tctggctca  1080
attcaattt  tcagtttca  tccagaatg  tcaggtgga  caaactacg  attaacatg  1140
ttcctgcta  aataatttg  gagccaatt  cagaatgct  tgttgccag  ttaattatt  1200
gatgggcag  ccaccatgt  ttcagatgg  atattatgg  atttttcat  tgtcattgc  1260
tggcatggt  tatatttga  tacattcaa  tcaggggtg  ccagggtgg  acactgtgt  1320
tttcaaaac  tgattatgc  gtcgcctgg  tcatccgcg  atccatgac  atatacatt  1380
ttttgtctg  attatggga  ccaactata  gctggagaa  tggtcgcta  agattacgc  1440
gtgggggta  agcagagga  atcctagat  tataactac  gctttgtga  tgtatataa  1500
ggaaaaaag  gaagtatta  aaattatgt  tatataaat  cttttaaaa  tctaccttc  1560
gtagtttta  cacatgtat  ttttggtat  tgttcttta  tttattttt  catggcact  1620
gcatctgtg  aaaaaaa  1637



<210> 841
<211> 394
<212> PRT
<213> Homo sapiens
<308> Q16739
<400> 841

Met Ala Leu Leu Asp Leu Ala Leu Glu Gly Met Ala Val Phe Gly Phe 
  1               5                  10                  15
Val Leu Phe Leu Val Leu Trp Leu Met His Phe Met Ala Ile Ile Tyr 
             20                  25                  30
Thr Arg Leu His Leu Asn Lys Lys Ala Thr Asp Lys Gln Pro Tyr Ser 
         35                  40                  45
Lys Leu Pro Gly Val Ser Leu Leu Lys Pro Leu Lys Gly Val Asp Pro 
     50                  55                  60
Asn Leu Ile Asn Asn Leu Glu Thr Phe Phe Glu Leu Asp Tyr Pro Lys 
 65                  70                  75                  80
Tyr Glu Val Leu Leu Cys Val Gln Asp His Asp Asp Pro Ala Ile Asp 
                 85                  90                  95
Val Cys Lys Lys Leu Leu Gly Lys Tyr Pro Asn Val Asp Ala Arg Leu 
             100                105                110
Phe Ile Gly Gly Lys Lys Val Gly Ile Asn Pro Lys Ile Asn Asn Leu 
         115                120                125
Met Pro Gly Tyr Glu Val Ala Lys Tyr Asp Leu Ile Trp Ile Cys Asp 
     130                135                140
Ser Gly Ile Arg Val Ile Pro Asp Thr Leu Thr Asp Met Val Asn Gln 
 145                150                155                160
Met Thr Glu Lys Val Gly Leu Val His Gly Leu Pro Tyr Val Ala Asp 
                 165                170                175
Arg Gln Gly Phe Ala Ala Thr Leu Glu Gln Val Tyr Phe Gly Thr Ser 
             180                185                190
His Pro Arg Tyr Tyr Ile Ser Ala Asn Val Thr Gly Phe Lys Cys Val 
         195                200                205
Thr Gly Met Ser Cys Leu Met Arg Lys Asp Val Leu Asp Gln Ala Gly 
     210                215                220
Gly Leu Ile Ala Phe Ala Gln Tyr Ile Ala Glu Asp Tyr Phe Met Ala 
 225                230                235                240
Lys Ala Ile Ala Asp Arg Gly Trp Arg Phe Ala Met Ser Thr Gln Val 
                 245                250                255
Ala Met Gln Asn Ser Gly Ser Tyr Ser Ile Ser Gln Phe Gln Ser Arg 
             260                265                270
Met Ile Arg Trp Thr Lys Leu Arg Ile Asn Met Leu Pro Ala Thr Ile 
         275                280                285
Ile Cys Glu Pro Ile Ser Glu Cys Phe Val Ala Ser Leu Ile Ile Gly 
     290                295                300
Trp Ala Ala His His Val Phe Arg Trp Asp Ile Met Val Phe Phe Met 
 305                310                315                320
Cys His Cys Leu Ala Trp Phe Ile Phe Asp Tyr Ile Gln Leu Arg Gly 
                 325                330                335
Val Gln Gly Gly Thr Leu Cys Phe Ser Lys Leu Asp Tyr Ala Val Ala 
             340                345                350
Trp Phe Ile Arg Glu Ser Met Thr Ile Tyr Ile Phe Leu Ser Ala Leu 
         355                360                365
Trp Asp Pro Thr Ile Ser Trp Arg Thr Gly Arg Tyr Arg Leu Arg Cys 
     370                375                380
Gly Gly Thr Ala Glu Glu Ile Leu Asp Val 
 385                390



<210> 842
<211> 2611
<212> DNA
<213> Rattus norvegicus
<308> AF047707
<400> 842

atacgactc  ctatagggc  cgagcggtc  cccgggcag  tagcggccg  tgaattcta  60
aacagcggg  cgggggatg  cgctgctgg  cctggccca  gagggaatg  ccttgttcg  120
cttcgtgct  ttcgtggtg  tgtggctga  gcatttcat  tccatcatc  acacccggt  180
acacctcaa  aagaaggca  cagacaaac  gccgtacag  aagctccct  gagtctctc  240
tctgaaacc  ctgaagggg  tggacccta  cctaatcaa  aacttggag  cattctttg  300
actggatta  cccaaatat  aagtactcc  ttgtgtaca  gatcatgat  atccagcca  360
tgaggtgtg  aagaaactg  ttggaaaat  cccaaacgt  gatgctaga  tatttatag  420
tggtaaaaa  gttggcatt  atcctaaaa  taataattt  atgccagca  atgaagttg  480
aaagtatga  ctcatatgg  tttgtgata  cggaatacg  gtcattcca  acacattaa  540
tgacatggt  aatcagatg  cggagagag  ggggctggt  cacgggctt  catacgtag  600
tgacagaca  ggctttgct  ccaccttag  gcaggtata  tttggaact  cacacccaa  660
atcctatat  tctgccaat  tgaccggct  caagtgtgt  acggggatg  cttgcttga  720
gaggaagga  gtgctagat  aggcaggag  gctcatagc  tttgctcag  acattgcgg  780
agattactt  atggccaaa  caatagcgg  ccgaggctg  aagttttca  tgtctacgc  840
agttgccat  caaaactct  gttcatact  catttctca  tttcaatcc  gaatgatca  900
gtggaccaa  ttgaggatt  acatgcttc  tgccacaat  atttgtgag  caatttcag  960
atgctttgt  gccagttta  ttatcgggt  ggcagccca  cacgtgttc  gatgggata  1020
catggtttt  ttcatgtgt  actgcctgg  atggtttat  tttgactac  ttcaactca  1080
gggtgtcca  ggtggcaca  tatgctttt  aaaacttga  tatgctgtg  cttggttca  1140
ccgcgaatc  atgacaata  acattttct  gtcggcact  tgggaccct  ctataagct  1200
gagagccgg  cgctacagg  tgcgctgtg  agggacggc  gaggagatc  tggatgtgt  1260
acaaggcct  tgtggccga  tggacagga  ggaatggaa  tgttataga  tatgtttat  1320
gagactttc  aggacctgc  ttcagtggc  catccgtgt  tgtgtggta  ccgctcttt  1380
atttattcg  atggccctt  catctgtga  aagcaaaaa  acaaaagca  aacatgtct  1440
tagtcgtgg  caaacagtg  attttatgg  ggtagagaa  caagacaat  ggttctagg  1500
agtgggttt  gttgttgtt  attttttta  acaaatata  atatatatc  atcaataca  1560
acacacaca  acacacaca  acacacacg  ctgctctgc  gcagacact  tgacagtat  1620
cttcagtag  gaaagtttc  tacctgagt  actcactct  aggtccgca  gggcagaac  1680
gcagctctg  gagagggaa  gggcaggtg  tggccgccc  tgtgtgaag  gaatgggtt  1740
tacagggag  cgctgactg  gaaactttt  catgcttta  gcctacctc  tgtagttgt  1800
gcagagcaa  tagaagtta  aagttgtga  atggtagct  ggccttgca  aaacaaatg  1860
gaaacttta  taataaaag  gccgagtct  gtatttata  aaatctgtg  ggttttttt  1920
gttttgttt  tttgttttt  ttttgtttt  ttttatttt  tggtctcat  gcaatgaac  1980
aaaagtggt  gagattggt  tttagtggt  accatgaat  gaaggcatc  tttggacca  2040
ctgttgttg  ttctgtctt  aaccatatt  atcactgtg  tgtaattag  agagctgaa  2100
ctttccttc  ctgctcctc  cccagcccg  cccatcttt  cattaatat  cattctctc  2160
ctctctccc  ctctccctc  ctccttctc  ctctctccc  ccctctctc  ctctctctc  2220
ctctctctc  ccttctctc  ctctctctc  ctctctctc  ttctcgcct  atgatgaat  2280
tgtttgaag  gcattttct  cgtgagcaa  ggcttggat  catattcca  tttttattt  2340
tttttctgt  aaatgggta  tattacccc  tgaggaaaa  ttgcacagt  agaaccagt  2400
tagttatga  ccactacat  tttattttt  tacattact  tctcacgag  tgagttttg  2460
tgagtgcgt  tgtcggttt  tttagtggc  tttggtgga  gcccttctt  gcgctgctg  2520
agtgaaatc  tgctgacta  ttagctttt  tgttgatct  agtatgggc  aagaaacaa  2580
atccaaatg  ctggacaga  ttctgtaaa  a  2611



<210> 843
<211> 394
<212> PRT
<213> Rattus norvegicus
<308> AAD02464
<400> 843

Met Ala Leu Leu Asp Leu Ala Gln Glu Gly Met Ala Leu Phe Gly Phe 
  1               5                  10                  15
Val Leu Phe Val Val Leu Trp Leu Met His Phe Met Ser Ile Ile Tyr 
             20                  25                  30
Thr Arg Leu His Leu Asn Lys Lys Ala Thr Asp Lys Gln Pro Tyr Ser 
         35                  40                  45
Lys Leu Pro Gly Val Ser Leu Leu Lys Pro Leu Lys Gly Val Asp Pro 
     50                  55                  60
Asn Leu Ile Asn Asn Leu Glu Thr Phe Phe Glu Leu Asp Tyr Pro Lys 
 65                  70                  75                  80
Tyr Glu Val Leu Leu Cys Val Gln Asp His Asp Asp Pro Ala Ile Glu 
                 85                  90                  95
Val Cys Lys Lys Leu Leu Gly Lys Tyr Pro Asn Val Asp Ala Arg Leu 
             100                105                110
Phe Ile Gly Gly Lys Lys Val Gly Ile Asn Pro Lys Ile Asn Asn Leu 
         115                120                125
Met Pro Ala Tyr Glu Val Ala Lys Tyr Asp Leu Ile Trp Ile Cys Asp 
     130                135                140
Ser Gly Ile Arg Val Ile Pro Asp Thr Leu Thr Asp Met Val Asn Gln 
 145                150                155                160
Met Thr Glu Arg Val Gly Leu Val His Gly Leu Pro Tyr Val Ala Asp 
                 165                170                175
Arg Gln Gly Phe Ala Ala Thr Leu Glu Gln Val Tyr Phe Gly Thr Ser 
             180                185                190
His Pro Arg Ser Tyr Ile Ser Ala Asn Val Thr Gly Phe Lys Cys Val 
         195                200                205
Thr Gly Met Ser Cys Leu Met Arg Lys Asp Val Leu Asp Gln Ala Gly 
     210                215                220
Gly Leu Ile Ala Phe Ala Gln Tyr Ile Ala Glu Asp Tyr Phe Met Ala 
 225                230                235                240
Lys Ala Ile Ala Asp Arg Gly Trp Lys Phe Ser Met Ser Thr Gln Val 
                 245                250                255
Ala Met Gln Asn Ser Gly Ser Tyr Ser Ile Ser Gln Phe Gln Ser Arg 
             260                265                270
Met Ile Arg Trp Thr Lys Leu Arg Ile Asn Met Leu Pro Ala Thr Ile 
         275                280                285
Ile Cys Glu Pro Ile Ser Glu Cys Phe Val Ala Ser Leu Ile Ile Gly 
     290                295                300
Trp Ala Ala His His Val Phe Arg Trp Asp Ile Met Val Phe Phe Met 
 305                310                315                320
Cys His Cys Leu Ala Trp Phe Ile Phe Asp Tyr Ile Gln Leu Arg Gly 
                 325                330                335
Val Gln Gly Gly Thr Leu Cys Phe Ser Lys Leu Asp Tyr Ala Val Ala 
             340                345                350
Trp Phe Ile Arg Glu Ser Met Thr Ile Tyr Ile Phe Leu Ser Ala Leu 
         355                360                365
Trp Asp Pro Thr Ile Ser Trp Arg Ala Gly Arg Tyr Arg Leu Arg Cys 
     370                375                380
Gly Gly Thr Ala Glu Glu Ile Leu Asp Val 
 385                390



<210> 844
<211> 1637
<212> DNA
<213> Homo sapiens
<308> D50840
<400> 844

gaggcgaac  ggagcgcgg  gccgcggtc  ccccgacca  agccgggag  ccgcagcac  60
cgcagccgc  cgcgagcgc  ccgaagaca  cgcgcaggc  agagcgcgc  ggcgggggc  120
cgcaggccc  gcccgcccc  tccgtcccc  cccccctcc  ccctttcct  tccccacct  180
cctctcgcc  cccgcgccc  cgcaccggg  gcccaccct  tcctcctcc  gcgggagcg  240
tgtccgtgt  ggcggccgc  gcgggccgg  ccggtccgg  gggccgggg  atggcgctg  300
tggacctgg  cttggaggg  atggccgtc  tcgggttcg  cctcttctt  gtgctgtgg  360
tgatgcatt  catggctat  atctacacc  gattacacc  caacaagaa  gcaactgac  420
aacagcctt  tagcaagct  ccaggtgtc  ctcttctga  accactgaa  ggggtagat  480
ctaacttaa  caacaacct  gaaacattc  ttgaattgg  ttatcccaa  tatgaagtg  540
tcctttgtg  acaagatca  gatgatcca  ccattgatg  atgtaagaa  cttcttgga  600
aatatccaa  tgttgatgc  agattgttt  taggtggta  aaaagttgg  attaatcct  660
aaattaata  tttaatgcc  ggatatgaa  ttgcaaagt  tgatcttat  tggatttgt  720
atagtggaa  aagagtaat  ccagatacg  ttactgaca  ggtgaatca  atgacagaa  780
aagtaggct  ggttcacgg  ctgccttac  tagcagaca  acagggctt  gctgccacc  840
tagagcagg  atattttgg  acttcacat  caagatact  tatctctgc  aatgtaact  900
gtttcaaat  tgtgacagg  atgtcttgt  taatgagaa  agatgtgtt  gatcaagca  960
gaggactta  agcttttgc  cagtacatt  ccgaagatt  ctttatggc  aaagcgata  1020
ctgaccgag  ttggaggtt  gcaatgtcc  ctcaagttg  aatgcaaaa  tctggctca  1080
attcaattt  tcagtttca  tccagaatg  tcaggtgga  caaactacg  attaacatg  1140
ttcctgcta  aataatttg  gagccaatt  cagaatgct  tgttgccag  ttaattatt  1200
gatgggcag  ccaccatgt  ttcagatgg  atattatgg  atttttcat  tgtcattgc  1260
tggcatggt  tatatttga  tacattcaa  tcaggggtg  ccagggtgg  acactgtgt  1320
tttcaaaac  tgattatgc  gtcgcctgg  tcatccgcg  atccatgac  atatacatt  1380
ttttgtctg  attatggga  ccaactata  gctggagaa  tggtcgcta  agattacgc  1440
gtgggggta  agcagagga  atcctagat  tataactac  gctttgtga  tgtatataa  1500
ggaaaaaag  gaagtatta  aaattatgt  tatataaat  cttttaaaa  tctaccttc  1560
gtagtttta  cacatgtat  ttttggtat  tgttcttta  tttattttt  catggcact  1620
gcatctgtg  aaaaaaa  1637



<210> 845
<211> 394
<212> PRT
<213> Homo sapiens
<308> Q16739
<400> 845

Met Ala Leu Leu Asp Leu Ala Leu Glu Gly Met Ala Val Phe Gly Phe 
  1               5                  10                  15
Val Leu Phe Leu Val Leu Trp Leu Met His Phe Met Ala Ile Ile Tyr 
             20                  25                  30
Thr Arg Leu His Leu Asn Lys Lys Ala Thr Asp Lys Gln Pro Tyr Ser 
         35                  40                  45
Lys Leu Pro Gly Val Ser Leu Leu Lys Pro Leu Lys Gly Val Asp Pro 
     50                  55                  60
Asn Leu Ile Asn Asn Leu Glu Thr Phe Phe Glu Leu Asp Tyr Pro Lys 
 65                  70                  75                  80
Tyr Glu Val Leu Leu Cys Val Gln Asp His Asp Asp Pro Ala Ile Asp 
                 85                  90                  95
Val Cys Lys Lys Leu Leu Gly Lys Tyr Pro Asn Val Asp Ala Arg Leu 
             100                105                110
Phe Ile Gly Gly Lys Lys Val Gly Ile Asn Pro Lys Ile Asn Asn Leu 
         115                120                125
Met Pro Gly Tyr Glu Val Ala Lys Tyr Asp Leu Ile Trp Ile Cys Asp 
     130                135                140
Ser Gly Ile Arg Val Ile Pro Asp Thr Leu Thr Asp Met Val Asn Gln 
 145                150                155                160
Met Thr Glu Lys Val Gly Leu Val His Gly Leu Pro Tyr Val Ala Asp 
                 165                170                175
Arg Gln Gly Phe Ala Ala Thr Leu Glu Gln Val Tyr Phe Gly Thr Ser 
             180                185                190
His Pro Arg Tyr Tyr Ile Ser Ala Asn Val Thr Gly Phe Lys Cys Val 
         195                200                205
Thr Gly Met Ser Cys Leu Met Arg Lys Asp Val Leu Asp Gln Ala Gly 
     210                215                220
Gly Leu Ile Ala Phe Ala Gln Tyr Ile Ala Glu Asp Tyr Phe Met Ala 
 225                230                235                240
Lys Ala Ile Ala Asp Arg Gly Trp Arg Phe Ala Met Ser Thr Gln Val 
                 245                250                255
Ala Met Gln Asn Ser Gly Ser Tyr Ser Ile Ser Gln Phe Gln Ser Arg 
             260                265                270
Met Ile Arg Trp Thr Lys Leu Arg Ile Asn Met Leu Pro Ala Thr Ile 
         275                280                285
Ile Cys Glu Pro Ile Ser Glu Cys Phe Val Ala Ser Leu Ile Ile Gly 
     290                295                300
Trp Ala Ala His His Val Phe Arg Trp Asp Ile Met Val Phe Phe Met 
 305                310                315                320
Cys His Cys Leu Ala Trp Phe Ile Phe Asp Tyr Ile Gln Leu Arg Gly 
                 325                330                335
Val Gln Gly Gly Thr Leu Cys Phe Ser Lys Leu Asp Tyr Ala Val Ala 
             340                345                350
Trp Phe Ile Arg Glu Ser Met Thr Ile Tyr Ile Phe Leu Ser Ala Leu 
         355                360                365
Trp Asp Pro Thr Ile Ser Trp Arg Thr Gly Arg Tyr Arg Leu Arg Cys 
     370                375                380
Gly Gly Thr Ala Glu Glu Ile Leu Asp Val 
 385                390



<210> 846
<211> 5729
<212> DNA
<213> Rattus norvegicus
<308> AF048687
<400> 846

agcctgcag  ggtctcggg  cgcacaggg  tgccgggat  gtcctcgtg  gtgtccgca  60
tccgagatc  ccgcgtgtc  gtcatctgt  tccttcgtc  tccgggccc  ggccgcgcg  120
atccgccgg  tagtccggg  tccgtgcgg  gggcggcgg  gcctctccc  cgggccggg  180
ggcgggaat  cggttgcct  ggccggctg  gcagcgggc  cggctgcaa  cggaacccg  240
gtgcactcg  cgctggccg  gacgccgcc  tggcctgct  tcggctccc  aggccgccc  300
gcgctctgg  gcccggcgc  gaatgaggt  caggccgcg  accgccgac  ccccctccg  360
ggccccctg  ttcaacgcg  ccgcccgcg  ctcgcgtgc  ccagcgccc  cgttagagc  420
tcgcactgg  agcgctcgc  gaggcacag  cctgcagag  gcacgccac  cggcccggg  480
cccgatcgc  gggactcgc  tcttggaca  cgccccagg  gcgggaccc  gacacgctg  540
aagcgcgcg  gccgcctcc  catcgcaga  ctcctctag  ctggcccgt  gctttggcc  600
ccacggagc  ggatctccc  gcctccctc  acatttctc  gcatccttt  aacaccctt  660
ccgctgctc  accacctcc  attcattgc  tccatttct  cttcccggc  cggttcttc  720
tcccataac  tccccggcc  gaccccgct  cccacccgg  acattcatg  aagtttagg  780
cctggaccg  ggctcggag  ctggcctga  agcgcagcg  agctgctgg  agggcagag  840
aagatgtct  cgctcaagc  gatgatgcg  gtctccaat  gctccctga  cgccttcat  900
ttcttcttc  ccctctcca  gtcctgtct  tatttcatc  atgtggctc  aggcatcgc  960
aacacatac  tctttatgg  acaagctag  ggcatcatg  tgagagaaa  tgtgaaaac  1020
attggacac  tgatcaggc  gtataccaa  aaaaacact  cgctcaatg  gacagatta  1080
cccgaaggc  ataatacaa  tgactatct  gttcaaaca  caacgtatc  tccgcagaa  1140
ttcacgtat  caccgcacc  cccctgtcc  gagaagctg  cttatatgc  gggattcct  1200
agtgtcaac  tgagtgaaa  cagctttga  gaagtccat  agctcttct  caaggactc  1260
gagattgag  cgggaggcc  ctggaggcc  caggactgc  agcctagat  gaaggtggc  1320
gttctcatc  ccttccgta  ccgccatga  cacctcccg  tctttttcc  gcacctgat  1380
ccgatgctc  agaaacaga  gctggaatt  gccttttat  tcatcgaac  gaccggcac  1440
caaccgttc  atcgtgcca  gctctttaa  gtgggtttc  aagaggcca  gaaggacag  1500
gcctgggac  gtgtgatct  ccacgacgt  gatcatctt  ctgagaacg  tcggaacta  1560
tacggatgc  gggagatgc  gcggcactt  gcagcgaag  tggacaagt  catgtacat  1620
cttccttat  aggagttct  tggtggggt  agtggcctg  cagtggagc  atttaggaa  1680
atcaatggc  ttcccaatg  cttctgggg  tggggagga  aggatgacg  cctttggaa  1740
agagttcac  actctggat  caatgtaac  cggccagag  gggacttgg  aaaatatac  1800
tctattccc  atcaccatc  aggggaagt  caattttta  gacggtata  attacttcg  1860
tattctaag  agcgtcagt  cattgatgg  ttgaacaat  tattataca  acccaaaat  1920
ctggttgac  ggctgtata  aaatatatc  gtaaacctc  tgccggagt  agctccagt  1980
gaagactat  aaaaagaag  cattcccgt  gtggggtag  ccacagcac  gaatcatga  2040
cttggcttg  aatgcactc  ccgtggaag  tagagattg  tgtgtatct  agtgtccca  2100
tctgtaaaa  gaaccagca  tccttaatg  ttacagcgt  ggctccatc  gtcacactc  2160
ccactctcc  ccctgctgg  agcacctcc  atggcgagc  ctgtcgaga  acaaaccca  2220
tgcttggga  tggaagtga  gaaaactcc  tacacagag  agatttttt  tatactgaa  2280
tctataatt  aattcaaga  aatgctttt  tttccgttc  aacatattt  gtacatatg  2340
gatgtaaat  aaatatgtt  aaattgttg  aaaataaga  gtcataatt  tgcatgtaa  2400
tggttatgc  ttcattgga  ttttataga  atttttttt  tttgcatgg  gggaaaaaa  2460
tgtaaattt  tgtcgccag  caaaggtta  gccttgtgt  aaatgaagg  actgtcagc  2520
acggacaaa  ataataccg  aactgtttc  ttgaactgg  gttcagctt  agccttcag  2580
ctcatggga  gaggcacag  cctctgagg  ctttgaagg  aggaaggaa  gactcgaat  2640
gcttttctt  ctgccagga  tacctgttt  gtttgtttg  ttttttcac  tgcttgcag  2700
ctcatcaga  cttgccaag  cagcagcca  attgtttat  catactgca  gagtattac  2760
aagaaaatc  tcagagttg  aaagtgaca  gctgtacag  acctcttcg  gttaaatgt  2820
tctatgtac  tctgctgtg  cagggatct  gtgcctcaa  aaaaaaatg  ccccaaggt  2880
gtgtttata  acggtctat  tttttttca  tctcataat  aacagcatt  ttatttcca  2940
tttagaaga  ccaaaagaa  gtatcttct  ttaaaaaca  tttttttaa  gaatgaatt  3000
atggaaaat  cagtagtgc  tatacagat  aattatact  ttagatgag  aattagatg  3060
tctattttt  tgaagataa  tgcttagat  aaaacagac  ttaacttta  ttctcaaac  3120
tacatagtt  cctttcaca  cagccagtc  cttgaactg  ttttttttt  tttttttcc  3180
ctttcaaga  atctctggt  ttattcaaa  ttttttttc  ctaccagta  aatttaatg  3240
ccccccccc  ccccgtccc  agtggagct  ggaattgaa  ctagggcct  tagacttac  3300
ttaaaatca  tattgtatg  gtggatgct  tgacttctg  actaggtct  acagcctaa  3360
gccaggtct  ctcatcctc  tcacttggg  gaggctttt  acaaccaaa  aacaacaaa  3420
cccaaacag  gttctgaaa  ttatcaatt  taaagattc  tgaaaaata  cttgtattc  3480
catgtaaga  cttatctcc  atatttaaa  aaattgaaa  catcgccta  ctgtcaagt  3540
aaccctccc  aagagcaaa  agtgagaga  ttctgaatg  ggggaagtt  gtccccttg  3600
ctgacgtga  agcttagct  gcagttgtc  ttgtctgtc  cagttttaa  gctgatggc  3660
acaagccaa  gtaattaga  ccttacacc  gagaagaca  acaccctat  tgttgtgac  3720
gcagtcttt  caggttctt  ttagacgtg  ttctaaaat  cttacctcc  aactttttt  3780
gttactcaa  gtagtgggg  gggggggaa  cacaacctg  ggaaatgaa  atttttgta  3840
gctatcagt  attctctgt  tcttgtggc  aatgaggtg  ttaattcga  ggaatgaca  3900
taaagtgta  tgttaatgt  aaggctggt  agacaggac  ctgggtgtg  ggtgagccc  3960
gccctggtc  ctcctcctg  ttctgtgga  tgtggtacc  cgtggattc  tactggggg  4020
aacacactt  ataaggtga  aggctatcc  cagtcagca  cttttgcat  gatatatag  4080
tcacagctt  aggaaaatt  agaactggt  aactgcctt  ctctcttag  gtaagtctg  4140
cattaacat  gctgcggga  tcggatgta  ttctgctaa  tcttcatgc  gaatctgct  4200
tgtcagctt  tgagaaccg  cttttctaa  tcagacctg  aattatttt  tttttcttt  4260
tcttttttt  ttttttttt  tttggagct  aggactgaa  ccagggcct  gagcttgct  4320
ggcaagagc  ctaccactg  gctaaatcc  caaccccct  gaattattt  cagtagtga  4380
tagtgatct  tatatgtca  cacaaatga  agttttgcc  tgttaccat  accacagtg  4440
atctcctcc  tctatatta  cccaagcag  cagtctgat  gaatcaaat  cacttggtg  4500
ctttgcact  tctgcccac  tccgctgcc  tgccaacgg  ggtatttaa  cgtggtttt  4560
gtttgcttt  gcctgaaca  gtcaaatcg  gacagttga  acttacctg  gattaggaa  4620
aatgtcctc  ggtaactta  ctgtcactt  tcttagact  ggagccagt  tggccacag  4680
tgctgggag  ccctcgtgg  actggggaa  tgatcgatg  ctttgaact  aagaaagaa  4740
gcatgactg  caggccgaa  gttcccacg  ccactgtaa  attctgtct  attttttaa  4800
gaagatgtc  tttaattat  tgccaaaac  agggtttta  tgaagtggc  tccccagtc  4860
cctttttat  gttattttc  ggtgtagac  cttgaggtg  ctcagggta  aaaggtgcc  4920
ctcccaagc  tgacaacct  cgcttgatc  ctggggttc  cactgtaga  ggagaggac  4980
accctggta  attgttctc  gacttctgt  tgtgtgcgg  tcgcgctca  acacacaca  5040
acacacaca  acacacgcg  gcgcgcaag  caaattaaa  ggtatataa  agttaaatt  5100
ctgttttat  aaacggtgt  taataagaa  atatttata  aatttaagt  caaaattat  5160
tattaaaaa  tcctattcc  gccagtcaa  ggtggagtt  gcctttaat  caagctctc  5220
ggaagcaag  caggttctc  gaattggag  ccagcctgg  ctgtggagt  agttccaag  5280
cagctgggg  gacacagag  aactgtctc  aaaacaaaa  caaatcaaa  caaaaactg  5340
tattccagt  gatactgat  accattgta  aagagagca  aaatatcat  aatacaata  5400
cgtcccttt  ggactccct  ggggggaag  agattgtat  tgtgtcatt  tatctgccc  5460
gtttcttta  aaataacac  ctagatttc  tgccttggg  ttgcagagt  gttgagaag  5520
aaactgtcg  cgtgttttt  ggaaggtgg  agtgtactt  agattattt  ttatgaaat  5580
gagtacttc  atgtaagtg  gttgatgta  acgctagtg  tttctcgct  ttttttttt  5640
tcttgtttt  cttctcatg  aaatgtttg  acttttttt  tcattgtct  ttatgaaat  5700
caatgttct  aagaaaaaa  aaaaaaaaa  5729



<210> 847
<211> 382
<212> PRT
<213> Rattus norvegicus
<308> AAC24515
<400> 847

Met Ser Ala Leu Lys Arg Met Met Arg Val Ser Asn Arg Ser Leu Ile 
  1               5                  10                  15
Ala Phe Ile Phe Phe Phe Ser Leu Ser Thr Ser Cys Leu Tyr Phe Ile 
             20                  25                  30
Tyr Val Ala Pro Gly Ile Ala Asn Thr Tyr Leu Phe Met Val Gln Ala 
         35                  40                  45
Arg Gly Ile Met Leu Arg Glu Asn Val Lys Thr Ile Gly His Met Ile 
     50                  55                  60
Arg Leu Tyr Thr Asn Lys Asn Thr Thr Leu Asn Gly Thr Asp Tyr Pro 
 65                  70                  75                  80
Glu Gly Asn Asn Thr Ser Asp Tyr Leu Val Gln Thr Thr Thr Tyr Leu 
                 85                  90                  95
Pro Gln Asn Phe Thr Tyr Ser Pro His Leu Pro Cys Pro Glu Lys Leu 
             100                105                110
Pro Tyr Met Arg Gly Phe Leu Ser Val Asn Val Ser Glu Ile Ser Phe 
         115                120                125
Asp Glu Val His Gln Leu Phe Ser Lys Asp Ser Glu Ile Glu Pro Gly 
     130                135                140
Gly His Trp Arg Pro Gln Asp Cys Lys Pro Arg Trp Lys Val Ala Val 
 145                150                155                160
Leu Ile Pro Phe Arg Asn Arg His Glu His Leu Pro Ile Phe Phe Leu 
                 165                170                175
His Leu Ile Pro Met Leu Gln Lys Gln Arg Leu Glu Phe Ala Phe Tyr 
             180                185                190
Val Ile Glu Gln Thr Gly Thr Gln Pro Phe Asn Arg Ala Met Leu Phe 
         195                200                205
Asn Val Gly Phe Lys Glu Ala Met Lys Asp Arg Ala Trp Asp Cys Val 
     210                215                220
Ile Phe His Asp Val Asp His Leu Pro Glu Asn Asp Arg Asn Tyr Tyr 
 225                230                235                240
Gly Cys Gly Glu Met Pro Arg His Phe Ala Ala Lys Leu Asp Lys Tyr 
                 245                250                255
Met Tyr Ile Leu Pro Tyr Lys Glu Phe Phe Gly Gly Val Ser Gly Leu 
             260                265                270
Thr Val Glu Gln Phe Arg Lys Ile Asn Gly Phe Pro Asn Ala Phe Trp 
         275                280                285
Gly Trp Gly Gly Glu Asp Asp Asp Leu Trp Asn Arg Val His Tyr Ser 
     290                295                300
Gly Tyr Asn Val Thr Arg Pro Glu Gly Asp Leu Gly Lys Tyr Thr Ser 
 305                310                315                320
Ile Pro His His His Arg Gly Glu Val Gln Phe Leu Gly Arg Tyr Lys 
                 325                330                335
Leu Leu Arg Tyr Ser Lys Glu Arg Gln Phe Ile Asp Gly Leu Asn Asn 
             340                345                350
Leu Leu Tyr Thr Pro Lys Ile Leu Val Asp Arg Leu Tyr Thr Asn Ile 
         355                360                365
Ser Val Asn Leu Met Pro Glu Leu Ala Pro Val Glu Asp Tyr 
     370                375                380



<210> 848
<211> 2147
<212> DNA
<213> Homo sapiens
<308> AF069054
<400> 848

ctcgggccc  ctccccaga  cctccccgc  cggaccccg  tgcagtgtc  gggttctca  60
cacatttat  gaagtttag  gcctggaca  tggccccga  tccggcctg  gagcgcagc  120
tgggctgct  gcagggaag  ggaagatgt  tgtgctcag  cggatgatg  gggtttcca  180
tcgctctct  ctcgccttc  tcttctttt  ctccctctc  tcgtcctgt  tgtacttca  240
ctatgtggc  ccaggcatc  attatcccg  aggcaataa  tcaagtgat  atcttgttc  300
aacaacaac  tatctcccg  aaaacttca  atactcacc  tacctcccc  gtccagaaa  360
gctgcctta  atgcgagga  tcctcaatg  caatgtaag  gaagtcagt  ttgatgaaa  420
tcatcaact  ttctccaag  atttagata  tgagccagg  ggtcattgg  ggccaaaag  480
ctgtaaacc  agatggaag  tggcagttc  cattccttt  cgtaatcgc  atgaacatc  540
tccaatttt  ttcttacat  tgattccaa  gctccagaa  cagcggctg  aatttgcgt  600
ttatgtcgt  gaacagact  gcacacaac  ttttaaccg  gcgatgctt  tcaatgtgg  660
cttcaaaga  gccatgaaa  acagtgtct  ggactgtgt  atcttccac  atgtggatc  720
tctacctga  aatgaccgg  actattacg  atgtggaga  atgccacgt  attttgctg  780
aaagctgga  aaatacatg  atattcttc  atataaaga  ttttttggt  gtgtaagtg  840
gctgacagt  gaacaattt  gaaagatca  tggttttcc  aatgccttc  ggggatggg  900
aggagaaga  gatgacctt  ggaacagag  tcactatgc  ggatataat  taaccagac  960
agagggaga  ttaggaaaa  acaagtcaa  tcctcatca  catagaggt  aagtccagt  1020
tttaggacg  tataaatta  taaggtatt  caaggagcg  cagtacatc  atggactga  1080
caatttaat  tataggcca  aaatactgg  tgataggtt  tatacaaac  tatctgtaa  1140
cctcatgcc  gagttagct  caatcgaag  ctattaaaa  aagtggctg  cgtggcaag  1200
tagaccaca  tgctggatc  taaacttgg  gcgcgctct  agtggaggt  agtgattgg  1260
tgtgtcaca  tgccctttt  tctgagaag  gccagcagt  cacagtgtt  acagagtgg  1320
actatatac  gtcaccctt  tctcacccc  tcctccctg  tctgagaca  acccctgtg  1380
cgagcaccg  agaaacggg  agccactac  taagatcgg  agttaagag  gctccctcc  1440
aagagaaaa  ttttatact  aaatctata  tttaattca  gagaatgct  ttatttccg  1500
ttaaacata  tttgtatat  tgtgatata  attaatgtg  gcaaattgt  taaaaatta  1560
atgtgttgc  gttttgcat  taatcggtt  tacctttat  ggactttta  agacatttt  1620
tatttgcat  aaaaaaact  actaaattt  catcactaa  caaaggtta  cccttgtgt  1680
aaatgaagg  actgtcaat  attgacagc  aactaatac  gtaaactgt  atactagtt  1740
tgagcttta  acctcagcc  tttgtgtgg  agaagtcac  gctttctta  gctttaaag  1800
aaaagaagg  aggacttaa  tagcttttc  tcctaccgg  attacctat  tttttcctt  1860
cttgcaatc  catctgatt  tgctagaaa  cacaaccat  ttgtttatg  atattgcat  1920
agtattacc  agaaaaatc  ttaaaagtt  tgatgtgac  tgatataaa  gatctcttt  1980
tgttaaatg  ctttccatg  acctctggt  tgtcaggga  tttgtgcct  aaaaaatgt  2040
tccaaggtt  tgtgtttat  ctgtgtatt  tttttaaat  cacggtgaa  agcactttt  2100
ttatttcca  ttcagaaga  ccaaaaaaa  aaaaaaaaa  aaaaaaa  2147



<210> 849
<211> 382
<212> PRT
<213> Homo sapiens
<308> Q9UBX8
<400> 849

Met Ser Val Leu Arg Arg Met Met Arg Val Ser Asn Arg Ser Leu Leu 
  1               5                  10                  15
Ala Phe Ile Phe Phe Phe Ser Leu Ser Ser Ser Cys Leu Tyr Phe Ile 
             20                  25                  30
Tyr Val Ala Pro Gly Ile Ala Asn Thr Tyr Leu Phe Met Val Gln Ala 
         35                  40                  45
Arg Gly Ile Met Leu Arg Glu Asn Val Lys Thr Ile Gly His Met Ile 
     50                  55                  60
Arg Leu Tyr Thr Asn Lys Asn Ser Thr Leu Asn Gly Thr Asp Tyr Pro 
 65                  70                  75                  80
Glu Gly Asn Asn Ser Ser Asp Tyr Leu Val Gln Thr Thr Thr Tyr Leu 
                 85                  90                  95
Pro Glu Asn Phe Thr Tyr Ser Pro Tyr Leu Pro Cys Pro Glu Lys Leu 
             100                105                110
Pro Tyr Met Arg Gly Phe Leu Asn Val Asn Val Ser Glu Val Ser Phe 
         115                120                125
Asp Glu Ile His Gln Leu Phe Ser Lys Asp Leu Asp Ile Glu Pro Gly 
     130                135                140
Gly His Trp Arg Pro Lys Asp Cys Lys Pro Arg Trp Lys Val Ala Val 
 145                150                155                160
Leu Ile Pro Phe Arg Asn Arg His Glu His Leu Pro Ile Phe Phe Leu 
                 165                170                175
His Leu Ile Pro Met Leu Gln Lys Gln Arg Leu Glu Phe Ala Phe Tyr 
             180                185                190
Val Ile Glu Gln Thr Gly Thr Gln Pro Phe Asn Arg Ala Met Leu Phe 
         195                200                205
Asn Val Gly Phe Lys Glu Ala Met Lys Asp Ser Val Trp Asp Cys Val 
     210                215                220
Ile Phe His Asp Val Asp His Leu Pro Glu Asn Asp Arg Asn Tyr Tyr 
 225                230                235                240
Gly Cys Gly Glu Met Pro Arg His Phe Ala Ala Lys Leu Asp Lys Tyr 
                 245                250                255
Met Tyr Ile Leu Pro Tyr Lys Glu Phe Phe Gly Gly Val Ser Gly Leu 
             260                265                270
Thr Val Glu Gln Phe Arg Lys Ile Asn Gly Phe Pro Asn Ala Phe Trp 
         275                280                285
Gly Trp Gly Gly Glu Asp Asp Asp Leu Trp Asn Arg Val His Tyr Ala 
     290                295                300
Gly Tyr Asn Val Thr Arg Pro Glu Gly Asp Leu Gly Lys Tyr Lys Ser 
 305                310                315                320
Ile Pro His His His Arg Gly Glu Val Gln Phe Leu Gly Arg Tyr Lys 
                 325                330                335
Leu Leu Arg Tyr Ser Lys Glu Arg Gln Tyr Ile Asp Gly Leu Asn Asn 
             340                345                350
Leu Ile Tyr Arg Pro Lys Ile Leu Val Asp Arg Leu Tyr Thr Asn Ile 
         355                360                365
Ser Val Asn Leu Met Pro Glu Leu Ala Pro Ile Glu Asp Tyr 
     370                375                380



<210> 850
<211> 1217
<212> DNA
<213> Rattus norvegicus
<308> AF048828
<400> 850

ctcggccaa  ccccgccgt  gctgccgct  ctcccgccg  caccgcctc  gagaacatg  60
ctgtgcctc  cacatatgc  gatcttggc  agtccgcca  ggatgtctt  accaagggc  120
acggctttg  cttaataaa  cttgatttg  aaacgaagt  cgagaatgg  ttggaattt  180
ctagctcag  ttctgccaa  acggagacc  ccaaagtga  gggcagtct  gaaaccaag  240
acagatgga  cgagtatgg  ctgacgttt  ctgagaagt  gaacacaga  aacaccctg  300
gctctgaga  caccgtgga  gaccagctt  ctcgtggac  gaagctgac  tttgattca  360
ctttctcgc  taacactgg  aaaaaaaat  ctaaaatca  gacagggta  aagagggag  420
atatcaacc  gggctgtga  atggacttt  acatcgctg  gccctcaat  cggggcgct  480
tggtgcttg  ctatgaggg  tttgacatc  ctgggccct  aatccgggg  gctctggtg  540
ttggctatg  gggttggct  gctggctac  agatgaatt  tgagacctc  aagtcccga  600
tgacccaga  caactttgc  gttggctac  agacggacg  attccagct  catactaat  660
tgaatgatg  gacggagtt  ggtggctcc  tttaccaga  ggtgaacaa  aagttggag  720
ctgctgtca  tctcgcctg  accgcagga  acagtaaca  tcgctttgg  atagcagcc  780
agtatcagg  cgaccctga  gcctgcttt  cggccaaag  gaacaactc  agtctaatt  840
gcttagggt  cactcagac  ctaaaacca  gtatcaaac  gacactgtc  gccctgctg  900
atggcaaga  cgtcaatgc  ggtggccac  agcttggtt  aggactgga  tttcaagcg  960
aaatgaata  tgtacaatc  ttaatttta  actattttg  agcatagct  ccttcagag  1020
ttagtgtac  ttttaatgt  atatgttgg  gatgcgaga  ttgattgat  ccacgttag  1080
cctccaggc  aaggatgac  cggctttaa  gtgtttacc  tttcagagg  acagcggaa  1140
ccccattcc  ggaagggtc  tttttagct  taggcgttg  gctggggag  agctcctct  1200
gagatccga  gctcgaa  1217



<210> 851
<211> 300
<212> PRT
<213> Rattus norvegicus
<308> Q9Z2L0
<400> 851

Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp Val 
  1               5                  10                  15
Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys Thr 
             20                  25                  30
Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr 
         35                  40                  45
Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr 
     50                  55                  60
Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu 
 65                  70                  75                  80
Gly Ser Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu 
                 85                  90                  95
Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala Lys 
             100                105                110
Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp Met 
         115                120                125
Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu Gly 
     130                135                140
Tyr Glu Gly Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val 
 145                150                155                160
Leu Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr 
                 165                170                175
Ser Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr 
             180                185                190
Asp Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly 
         195                200                205
Gly Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn 
     210                215                220
Leu Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala 
 225                230                235                240
Lys Tyr Gln Val Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn 
                 245                250                255
Ser Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile 
             260                265                270
Lys Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly 
         275                280                285
Gly His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
     290                295                300



<210> 852
<211> 614
<212> DNA
<213> Homo sapiens
<308> BI493778
<400> 852

tttttttaa  acaaacatt  tatttaatg  agaaattct  aggtacaaa  acattttgt  60
aatgtcagc  gtgatctac  ttcacctag  tacagagtt  tgtacaaat  aagtcatta  120
cattttcaa  gtcaaaaat  cagcacgct  ttaagagtt  tgtcagtgc  cattatccc  180
ctagatccc  caaagggca  actcaaaga  gaaacaaag  caacgccat  aataaccac  240
atattccac  ggctttctc  cctaggacg  actaacagg  agtttccac  gggaaaaat  300
ctcttttaa  aaattaaca  taaaaatag  agttactta  tatctagat  aacacaatt  360
gttttcaca  aagcttttg  tgctgtctg  actcaccat  cttttttct  gagagaaac  420
taccaaact  ttctcgagt  ttttttttt  ttttttttt  aggtttcaa  attttattc  480
agtttttta  gtgttgtta  ttacagcat  tgaagggga  gatctaatt  caacaaaat  540
gaagactct  aaatgtacc  attaaactg  taaaaaaca  attgagtgg  gagaataca  600
cagaagtcc  attt  614



<210> 853
<211> 282
<212> PRT
<213> Homo sapiens
<308> MMHUP3
<400> 853

Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp Val 
  1               5                  10                  15
Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys Thr 
             20                  25                  30
Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr 
         35                  40                  45
Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr 
     50                  55                  60
Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu 
 65                  70                  75                  80
Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu 
                 85                  90                  95
Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala Lys 
             100                105                110
Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp Met 
         115                120                125
Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu Gly 
     130                135                140
Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ala Lys 
 145                150                155                160
Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp Glu 
                 165                170                175
Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser 
             180                185                190
Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu Ala 
         195                200                205
Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys Tyr 
     210                215                220
Gln Ile Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser Ser 
 225                230                235                240
Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys Leu 
                 245                250                255
Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly His 
             260                265                270
Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
         275                280



<210> 854
<211> 1217
<212> DNA
<213> Rattus norvegicus
<308> AF048828
<400> 854

ctcggccaa  ccccgccgt  gctgccgct  ctcccgccg  caccgcctc  gagaacatg  60
ctgtgcctc  cacatatgc  gatcttggc  agtccgcca  ggatgtctt  accaagggc  120
acggctttg  cttaataaa  cttgatttg  aaacgaagt  cgagaatgg  ttggaattt  180
ctagctcag  ttctgccaa  acggagacc  ccaaagtga  gggcagtct  gaaaccaag  240
acagatgga  cgagtatgg  ctgacgttt  ctgagaagt  gaacacaga  aacaccctg  300
gctctgaga  caccgtgga  gaccagctt  ctcgtggac  gaagctgac  tttgattca  360
ctttctcgc  taacactgg  aaaaaaaat  ctaaaatca  gacagggta  aagagggag  420
atatcaacc  gggctgtga  atggacttt  acatcgctg  gccctcaat  cggggcgct  480
tggtgcttg  ctatgaggg  tttgacatc  ctgggccct  aatccgggg  gctctggtg  540
ttggctatg  gggttggct  gctggctac  agatgaatt  tgagacctc  aagtcccga  600
tgacccaga  caactttgc  gttggctac  agacggacg  attccagct  catactaat  660
tgaatgatg  gacggagtt  ggtggctcc  tttaccaga  ggtgaacaa  aagttggag  720
ctgctgtca  tctcgcctg  accgcagga  acagtaaca  tcgctttgg  atagcagcc  780
agtatcagg  cgaccctga  gcctgcttt  cggccaaag  gaacaactc  agtctaatt  840
gcttagggt  cactcagac  ctaaaacca  gtatcaaac  gacactgtc  gccctgctg  900
atggcaaga  cgtcaatgc  ggtggccac  agcttggtt  aggactgga  tttcaagcg  960
aaatgaata  tgtacaatc  ttaatttta  actattttg  agcatagct  ccttcagag  1020
ttagtgtac  ttttaatgt  atatgttgg  gatgcgaga  ttgattgat  ccacgttag  1080
cctccaggc  aaggatgac  cggctttaa  gtgtttacc  tttcagagg  acagcggaa  1140
ccccattcc  ggaagggtc  tttttagct  taggcgttg  gctggggag  agctcctct  1200
gagatccga  gctcgaa  1217



<210> 855
<211> 300
<212> PRT
<213> Rattus norvegicus
<308> Q9Z2L0
<400> 855

Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp Val 
  1               5                  10                  15
Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys Thr 
             20                  25                  30
Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr 
         35                  40                  45
Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr 
     50                  55                  60
Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu 
 65                  70                  75                  80
Gly Ser Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu 
                 85                  90                  95
Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala Lys 
             100                105                110
Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp Met 
         115                120                125
Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu Gly 
     130                135                140
Tyr Glu Gly Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val 
 145                150                155                160
Leu Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr 
                 165                170                175
Ser Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr 
             180                185                190
Asp Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly 
         195                200                205
Gly Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn 
     210                215                220
Leu Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala 
 225                230                235                240
Lys Tyr Gln Val Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn 
                 245                250                255
Ser Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile 
             260                265                270
Lys Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly 
         275                280                285
Gly His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
     290                295                300



<210> 856
<211> 614
<212> DNA
<213> Homo sapiens
<308> BI493778
<400> 856

tttttttaa  acaaacatt  tatttaatg  agaaattct  aggtacaaa  acattttgt  60
aatgtcagc  gtgatctac  ttcacctag  tacagagtt  tgtacaaat  aagtcatta  120
cattttcaa  gtcaaaaat  cagcacgct  ttaagagtt  tgtcagtgc  cattatccc  180
ctagatccc  caaagggca  actcaaaga  gaaacaaag  caacgccat  aataaccac  240
atattccac  ggctttctc  cctaggacg  actaacagg  agtttccac  gggaaaaat  300
ctcttttaa  aaattaaca  taaaaatag  agttactta  tatctagat  aacacaatt  360
gttttcaca  aagcttttg  tgctgtctg  actcaccat  cttttttct  gagagaaac  420
taccaaact  ttctcgagt  ttttttttt  ttttttttt  aggtttcaa  attttattc  480
agtttttta  gtgttgtta  ttacagcat  tgaagggga  gatctaatt  caacaaaat  540
gaagactct  aaatgtacc  attaaactg  taaaaaaca  attgagtgg  gagaataca  600
cagaagtcc  attt  614



<210> 857
<211> 282
<212> PRT
<213> Homo sapiens
<308> MMHUP3
<400> 857

Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp Val 
  1               5                  10                  15
Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys Thr 
             20                  25                  30
Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr 
         35                  40                  45
Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr 
     50                  55                  60
Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu 
 65                  70                  75                  80
Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu 
                 85                  90                  95
Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala Lys 
             100                105                110
Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp Met 
         115                120                125
Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu Gly 
     130                135                140
Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ala Lys 
 145                150                155                160
Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp Glu 
                 165                170                175
Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser 
             180                185                190
Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu Ala 
         195                200                205
Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys Tyr 
     210                215                220
Gln Ile Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser Ser 
 225                230                235                240
Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys Leu 
                 245                250                255
Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly His 
             260                265                270
Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
         275                280



<210> 858
<211> 1217
<212> DNA
<213> Rattus norvegicus
<308> AF048828
<400> 858

ctcggccaa  ccccgccgt  gctgccgct  ctcccgccg  caccgcctc  gagaacatg  60
ctgtgcctc  cacatatgc  gatcttggc  agtccgcca  ggatgtctt  accaagggc  120
acggctttg  cttaataaa  cttgatttg  aaacgaagt  cgagaatgg  ttggaattt  180
ctagctcag  ttctgccaa  acggagacc  ccaaagtga  gggcagtct  gaaaccaag  240
acagatgga  cgagtatgg  ctgacgttt  ctgagaagt  gaacacaga  aacaccctg  300
gctctgaga  caccgtgga  gaccagctt  ctcgtggac  gaagctgac  tttgattca  360
ctttctcgc  taacactgg  aaaaaaaat  ctaaaatca  gacagggta  aagagggag  420
atatcaacc  gggctgtga  atggacttt  acatcgctg  gccctcaat  cggggcgct  480
tggtgcttg  ctatgaggg  tttgacatc  ctgggccct  aatccgggg  gctctggtg  540
ttggctatg  gggttggct  gctggctac  agatgaatt  tgagacctc  aagtcccga  600
tgacccaga  caactttgc  gttggctac  agacggacg  attccagct  catactaat  660
tgaatgatg  gacggagtt  ggtggctcc  tttaccaga  ggtgaacaa  aagttggag  720
ctgctgtca  tctcgcctg  accgcagga  acagtaaca  tcgctttgg  atagcagcc  780
agtatcagg  cgaccctga  gcctgcttt  cggccaaag  gaacaactc  agtctaatt  840
gcttagggt  cactcagac  ctaaaacca  gtatcaaac  gacactgtc  gccctgctg  900
atggcaaga  cgtcaatgc  ggtggccac  agcttggtt  aggactgga  tttcaagcg  960
aaatgaata  tgtacaatc  ttaatttta  actattttg  agcatagct  ccttcagag  1020
ttagtgtac  ttttaatgt  atatgttgg  gatgcgaga  ttgattgat  ccacgttag  1080
cctccaggc  aaggatgac  cggctttaa  gtgtttacc  tttcagagg  acagcggaa  1140
ccccattcc  ggaagggtc  tttttagct  taggcgttg  gctggggag  agctcctct  1200
gagatccga  gctcgaa  1217



<210> 859
<211> 300
<212> PRT
<213> Rattus norvegicus
<308> Q9Z2L0
<400> 859

Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp Val 
  1               5                  10                  15
Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys Thr 
             20                  25                  30
Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr 
         35                  40                  45
Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr 
     50                  55                  60
Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu 
 65                  70                  75                  80
Gly Ser Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu 
                 85                  90                  95
Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala Lys 
             100                105                110
Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp Met 
         115                120                125
Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu Gly 
     130                135                140
Tyr Glu Gly Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val 
 145                150                155                160
Leu Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr 
                 165                170                175
Ser Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr 
             180                185                190
Asp Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly 
         195                200                205
Gly Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn 
     210                215                220
Leu Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala 
 225                230                235                240
Lys Tyr Gln Val Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn 
                 245                250                255
Ser Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile 
             260                265                270
Lys Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly 
         275                280                285
Gly His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
     290                295                300



<210> 860
<211> 614
<212> DNA
<213> Homo sapiens
<308> BI493778
<400> 860

tttttttaa  acaaacatt  tatttaatg  agaaattct  aggtacaaa  acattttgt  60
aatgtcagc  gtgatctac  ttcacctag  tacagagtt  tgtacaaat  aagtcatta  120
cattttcaa  gtcaaaaat  cagcacgct  ttaagagtt  tgtcagtgc  cattatccc  180
ctagatccc  caaagggca  actcaaaga  gaaacaaag  caacgccat  aataaccac  240
atattccac  ggctttctc  cctaggacg  actaacagg  agtttccac  gggaaaaat  300
ctcttttaa  aaattaaca  taaaaatag  agttactta  tatctagat  aacacaatt  360
gttttcaca  aagcttttg  tgctgtctg  actcaccat  cttttttct  gagagaaac  420
taccaaact  ttctcgagt  ttttttttt  ttttttttt  aggtttcaa  attttattc  480
agtttttta  gtgttgtta  ttacagcat  tgaagggga  gatctaatt  caacaaaat  540
gaagactct  aaatgtacc  attaaactg  taaaaaaca  attgagtgg  gagaataca  600
cagaagtcc  attt  614



<210> 861
<211> 282
<212> PRT
<213> Homo sapiens
<308> MMHUP3
<400> 861

Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp Val 
  1               5                  10                  15
Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys Thr 
             20                  25                  30
Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr 
         35                  40                  45
Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr 
     50                  55                  60
Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu 
 65                  70                  75                  80
Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu 
                 85                  90                  95
Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala Lys 
             100                105                110
Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp Met 
         115                120                125
Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu Gly 
     130                135                140
Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ala Lys 
 145                150                155                160
Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp Glu 
                 165                170                175
Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser 
             180                185                190
Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu Ala 
         195                200                205
Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys Tyr 
     210                215                220
Gln Ile Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser Ser 
 225                230                235                240
Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys Leu 
                 245                250                255
Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly His 
             260                265                270
Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
         275                280



<210> 862
<211> 1217
<212> DNA
<213> Rattus norvegicus
<308> AF048828
<400> 862

ctcggccaa  ccccgccgt  gctgccgct  ctcccgccg  caccgcctc  gagaacatg  60
ctgtgcctc  cacatatgc  gatcttggc  agtccgcca  ggatgtctt  accaagggc  120
acggctttg  cttaataaa  cttgatttg  aaacgaagt  cgagaatgg  ttggaattt  180
ctagctcag  ttctgccaa  acggagacc  ccaaagtga  gggcagtct  gaaaccaag  240
acagatgga  cgagtatgg  ctgacgttt  ctgagaagt  gaacacaga  aacaccctg  300
gctctgaga  caccgtgga  gaccagctt  ctcgtggac  gaagctgac  tttgattca  360
ctttctcgc  taacactgg  aaaaaaaat  ctaaaatca  gacagggta  aagagggag  420
atatcaacc  gggctgtga  atggacttt  acatcgctg  gccctcaat  cggggcgct  480
tggtgcttg  ctatgaggg  tttgacatc  ctgggccct  aatccgggg  gctctggtg  540
ttggctatg  gggttggct  gctggctac  agatgaatt  tgagacctc  aagtcccga  600
tgacccaga  caactttgc  gttggctac  agacggacg  attccagct  catactaat  660
tgaatgatg  gacggagtt  ggtggctcc  tttaccaga  ggtgaacaa  aagttggag  720
ctgctgtca  tctcgcctg  accgcagga  acagtaaca  tcgctttgg  atagcagcc  780
agtatcagg  cgaccctga  gcctgcttt  cggccaaag  gaacaactc  agtctaatt  840
gcttagggt  cactcagac  ctaaaacca  gtatcaaac  gacactgtc  gccctgctg  900
atggcaaga  cgtcaatgc  ggtggccac  agcttggtt  aggactgga  tttcaagcg  960
aaatgaata  tgtacaatc  ttaatttta  actattttg  agcatagct  ccttcagag  1020
ttagtgtac  ttttaatgt  atatgttgg  gatgcgaga  ttgattgat  ccacgttag  1080
cctccaggc  aaggatgac  cggctttaa  gtgtttacc  tttcagagg  acagcggaa  1140
ccccattcc  ggaagggtc  tttttagct  taggcgttg  gctggggag  agctcctct  1200
gagatccga  gctcgaa  1217



<210> 863
<211> 300
<212> PRT
<213> Rattus norvegicus
<308> Q9Z2L0
<400> 863

Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp Val 
  1               5                  10                  15
Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys Thr 
             20                  25                  30
Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr 
         35                  40                  45
Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr 
     50                  55                  60
Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu 
 65                  70                  75                  80
Gly Ser Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu 
                 85                  90                  95
Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala Lys 
             100                105                110
Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp Met 
         115                120                125
Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu Gly 
     130                135                140
Tyr Glu Gly Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val 
 145                150                155                160
Leu Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr 
                 165                170                175
Ser Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr 
             180                185                190
Asp Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly 
         195                200                205
Gly Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn 
     210                215                220
Leu Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala 
 225                230                235                240
Lys Tyr Gln Val Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn 
                 245                250                255
Ser Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile 
             260                265                270
Lys Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly 
         275                280                285
Gly His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
     290                295                300



<210> 864
<211> 614
<212> DNA
<213> Homo sapiens
<308> BI493778
<400> 864

tttttttaa  acaaacatt  tatttaatg  agaaattct  aggtacaaa  acattttgt  60
aatgtcagc  gtgatctac  ttcacctag  tacagagtt  tgtacaaat  aagtcatta  120
cattttcaa  gtcaaaaat  cagcacgct  ttaagagtt  tgtcagtgc  cattatccc  180
ctagatccc  caaagggca  actcaaaga  gaaacaaag  caacgccat  aataaccac  240
atattccac  ggctttctc  cctaggacg  actaacagg  agtttccac  gggaaaaat  300
ctcttttaa  aaattaaca  taaaaatag  agttactta  tatctagat  aacacaatt  360
gttttcaca  aagcttttg  tgctgtctg  actcaccat  cttttttct  gagagaaac  420
taccaaact  ttctcgagt  ttttttttt  ttttttttt  aggtttcaa  attttattc  480
agtttttta  gtgttgtta  ttacagcat  tgaagggga  gatctaatt  caacaaaat  540
gaagactct  aaatgtacc  attaaactg  taaaaaaca  attgagtgg  gagaataca  600
cagaagtcc  attt  614



<210> 865
<211> 282
<212> PRT
<213> Homo sapiens
<308> MMHUP3
<400> 865

Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp Val 
  1               5                  10                  15
Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys Thr 
             20                  25                  30
Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr 
         35                  40                  45
Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr 
     50                  55                  60
Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu 
 65                  70                  75                  80
Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu 
                 85                  90                  95
Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala Lys 
             100                105                110
Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp Met 
         115                120                125
Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu Gly 
     130                135                140
Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ala Lys 
 145                150                155                160
Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp Glu 
                 165                170                175
Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser 
             180                185                190
Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu Ala 
         195                200                205
Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys Tyr 
     210                215                220
Gln Ile Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser Ser 
 225                230                235                240
Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys Leu 
                 245                250                255
Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly His 
             260                265                270
Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
         275                280



<210> 866
<211> 1217
<212> DNA
<213> Rattus norvegicus
<308> AF048828
<400> 866

ctcggccaa  ccccgccgt  gctgccgct  ctcccgccg  caccgcctc  gagaacatg  60
ctgtgcctc  cacatatgc  gatcttggc  agtccgcca  ggatgtctt  accaagggc  120
acggctttg  cttaataaa  cttgatttg  aaacgaagt  cgagaatgg  ttggaattt  180
ctagctcag  ttctgccaa  acggagacc  ccaaagtga  gggcagtct  gaaaccaag  240
acagatgga  cgagtatgg  ctgacgttt  ctgagaagt  gaacacaga  aacaccctg  300
gctctgaga  caccgtgga  gaccagctt  ctcgtggac  gaagctgac  tttgattca  360
ctttctcgc  taacactgg  aaaaaaaat  ctaaaatca  gacagggta  aagagggag  420
atatcaacc  gggctgtga  atggacttt  acatcgctg  gccctcaat  cggggcgct  480
tggtgcttg  ctatgaggg  tttgacatc  ctgggccct  aatccgggg  gctctggtg  540
ttggctatg  gggttggct  gctggctac  agatgaatt  tgagacctc  aagtcccga  600
tgacccaga  caactttgc  gttggctac  agacggacg  attccagct  catactaat  660
tgaatgatg  gacggagtt  ggtggctcc  tttaccaga  ggtgaacaa  aagttggag  720
ctgctgtca  tctcgcctg  accgcagga  acagtaaca  tcgctttgg  atagcagcc  780
agtatcagg  cgaccctga  gcctgcttt  cggccaaag  gaacaactc  agtctaatt  840
gcttagggt  cactcagac  ctaaaacca  gtatcaaac  gacactgtc  gccctgctg  900
atggcaaga  cgtcaatgc  ggtggccac  agcttggtt  aggactgga  tttcaagcg  960
aaatgaata  tgtacaatc  ttaatttta  actattttg  agcatagct  ccttcagag  1020
ttagtgtac  ttttaatgt  atatgttgg  gatgcgaga  ttgattgat  ccacgttag  1080
cctccaggc  aaggatgac  cggctttaa  gtgtttacc  tttcagagg  acagcggaa  1140
ccccattcc  ggaagggtc  tttttagct  taggcgttg  gctggggag  agctcctct  1200
gagatccga  gctcgaa  1217



<210> 867
<211> 300
<212> PRT
<213> Rattus norvegicus
<308> Q9Z2L0
<400> 867

Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp Val 
  1               5                  10                  15
Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys Thr 
             20                  25                  30
Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr 
         35                  40                  45
Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr 
     50                  55                  60
Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu 
 65                  70                  75                  80
Gly Ser Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu 
                 85                  90                  95
Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala Lys 
             100                105                110
Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp Met 
         115                120                125
Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu Gly 
     130                135                140
Tyr Glu Gly Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val 
 145                150                155                160
Leu Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr 
                 165                170                175
Ser Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr 
             180                185                190
Asp Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly 
         195                200                205
Gly Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn 
     210                215                220
Leu Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala 
 225                230                235                240
Lys Tyr Gln Val Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn 
                 245                250                255
Ser Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile 
             260                265                270
Lys Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly 
         275                280                285
Gly His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
     290                295                300



<210> 868
<211> 614
<212> DNA
<213> Homo sapiens
<308> BI493778
<400> 868

tttttttaa  acaaacatt  tatttaatg  agaaattct  aggtacaaa  acattttgt  60
aatgtcagc  gtgatctac  ttcacctag  tacagagtt  tgtacaaat  aagtcatta  120
cattttcaa  gtcaaaaat  cagcacgct  ttaagagtt  tgtcagtgc  cattatccc  180
ctagatccc  caaagggca  actcaaaga  gaaacaaag  caacgccat  aataaccac  240
atattccac  ggctttctc  cctaggacg  actaacagg  agtttccac  gggaaaaat  300
ctcttttaa  aaattaaca  taaaaatag  agttactta  tatctagat  aacacaatt  360
gttttcaca  aagcttttg  tgctgtctg  actcaccat  cttttttct  gagagaaac  420
taccaaact  ttctcgagt  ttttttttt  ttttttttt  aggtttcaa  attttattc  480
agtttttta  gtgttgtta  ttacagcat  tgaagggga  gatctaatt  caacaaaat  540
gaagactct  aaatgtacc  attaaactg  taaaaaaca  attgagtgg  gagaataca  600
cagaagtcc  attt  614



<210> 869
<211> 282
<212> PRT
<213> Homo sapiens
<308> MMHUP3
<400> 869

Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp Val 
  1               5                  10                  15
Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys Thr 
             20                  25                  30
Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr 
         35                  40                  45
Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr 
     50                  55                  60
Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu 
 65                  70                  75                  80
Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu 
                 85                  90                  95
Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala Lys 
             100                105                110
Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp Met 
         115                120                125
Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu Gly 
     130                135                140
Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ala Lys 
 145                150                155                160
Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp Glu 
                 165                170                175
Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser 
             180                185                190
Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu Ala 
         195                200                205
Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys Tyr 
     210                215                220
Gln Ile Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser Ser 
 225                230                235                240
Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys Leu 
                 245                250                255
Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly His 
             260                265                270
Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
         275                280



<210> 870
<211> 1217
<212> DNA
<213> Rattus norvegicus
<308> AF048828
<400> 870

ctcggccaa  ccccgccgt  gctgccgct  ctcccgccg  caccgcctc  gagaacatg  60
ctgtgcctc  cacatatgc  gatcttggc  agtccgcca  ggatgtctt  accaagggc  120
acggctttg  cttaataaa  cttgatttg  aaacgaagt  cgagaatgg  ttggaattt  180
ctagctcag  ttctgccaa  acggagacc  ccaaagtga  gggcagtct  gaaaccaag  240
acagatgga  cgagtatgg  ctgacgttt  ctgagaagt  gaacacaga  aacaccctg  300
gctctgaga  caccgtgga  gaccagctt  ctcgtggac  gaagctgac  tttgattca  360
ctttctcgc  taacactgg  aaaaaaaat  ctaaaatca  gacagggta  aagagggag  420
atatcaacc  gggctgtga  atggacttt  acatcgctg  gccctcaat  cggggcgct  480
tggtgcttg  ctatgaggg  tttgacatc  ctgggccct  aatccgggg  gctctggtg  540
ttggctatg  gggttggct  gctggctac  agatgaatt  tgagacctc  aagtcccga  600
tgacccaga  caactttgc  gttggctac  agacggacg  attccagct  catactaat  660
tgaatgatg  gacggagtt  ggtggctcc  tttaccaga  ggtgaacaa  aagttggag  720
ctgctgtca  tctcgcctg  accgcagga  acagtaaca  tcgctttgg  atagcagcc  780
agtatcagg  cgaccctga  gcctgcttt  cggccaaag  gaacaactc  agtctaatt  840
gcttagggt  cactcagac  ctaaaacca  gtatcaaac  gacactgtc  gccctgctg  900
atggcaaga  cgtcaatgc  ggtggccac  agcttggtt  aggactgga  tttcaagcg  960
aaatgaata  tgtacaatc  ttaatttta  actattttg  agcatagct  ccttcagag  1020
ttagtgtac  ttttaatgt  atatgttgg  gatgcgaga  ttgattgat  ccacgttag  1080
cctccaggc  aaggatgac  cggctttaa  gtgtttacc  tttcagagg  acagcggaa  1140
ccccattcc  ggaagggtc  tttttagct  taggcgttg  gctggggag  agctcctct  1200
gagatccga  gctcgaa  1217



<210> 871
<211> 300
<212> PRT
<213> Rattus norvegicus
<308> Q9Z2L0
<400> 871

Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp Val 
  1               5                  10                  15
Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys Thr 
             20                  25                  30
Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr 
         35                  40                  45
Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr 
     50                  55                  60
Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu 
 65                  70                  75                  80
Gly Ser Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu 
                 85                  90                  95
Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala Lys 
             100                105                110
Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp Met 
         115                120                125
Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu Gly 
     130                135                140
Tyr Glu Gly Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val 
 145                150                155                160
Leu Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr 
                 165                170                175
Ser Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr 
             180                185                190
Asp Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly 
         195                200                205
Gly Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn 
     210                215                220
Leu Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala 
 225                230                235                240
Lys Tyr Gln Val Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn 
                 245                250                255
Ser Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile 
             260                265                270
Lys Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly 
         275                280                285
Gly His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
     290                295                300



<210> 872
<211> 614
<212> DNA
<213> Homo sapiens
<308> BI493778
<400> 872

tttttttaa  acaaacatt  tatttaatg  agaaattct  aggtacaaa  acattttgt  60
aatgtcagc  gtgatctac  ttcacctag  tacagagtt  tgtacaaat  aagtcatta  120
cattttcaa  gtcaaaaat  cagcacgct  ttaagagtt  tgtcagtgc  cattatccc  180
ctagatccc  caaagggca  actcaaaga  gaaacaaag  caacgccat  aataaccac  240
atattccac  ggctttctc  cctaggacg  actaacagg  agtttccac  gggaaaaat  300
ctcttttaa  aaattaaca  taaaaatag  agttactta  tatctagat  aacacaatt  360
gttttcaca  aagcttttg  tgctgtctg  actcaccat  cttttttct  gagagaaac  420
taccaaact  ttctcgagt  ttttttttt  ttttttttt  aggtttcaa  attttattc  480
agtttttta  gtgttgtta  ttacagcat  tgaagggga  gatctaatt  caacaaaat  540
gaagactct  aaatgtacc  attaaactg  taaaaaaca  attgagtgg  gagaataca  600
cagaagtcc  attt  614



<210> 873
<211> 282
<212> PRT
<213> Homo sapiens
<308> MMHUP3
<400> 873

Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp Val 
  1               5                  10                  15
Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys Thr 
             20                  25                  30
Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr 
         35                  40                  45
Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr 
     50                  55                  60
Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu 
 65                  70                  75                  80
Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu 
                 85                  90                  95
Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala Lys 
             100                105                110
Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp Met 
         115                120                125
Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu Gly 
     130                135                140
Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ala Lys 
 145                150                155                160
Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp Glu 
                 165                170                175
Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser 
             180                185                190
Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu Ala 
         195                200                205
Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys Tyr 
     210                215                220
Gln Ile Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser Ser 
 225                230                235                240
Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys Leu 
                 245                250                255
Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly His 
             260                265                270
Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
         275                280



<210> 874
<211> 3512
<212> DNA
<213> Rattus norvegicus
<308> AF049344
<400> 874

aagagaggg  ccttgctcc  gctgctgct  ctgctgctg  tactgttgc  acctcaact  60
tctctccac  ccaggtaag  agagggcaa  ctgcaaggc  agcctttgt  cgatgaaca  120
gatccgaaa  tttttccga  gaagtgggc  agtcttggc  tttatattt  tagcttctg  180
catctggct  ctctttgat  tggcagctc  ccgcctctc  ttcagtgag  tcaacacag  240
gatactcaa  gaagatatc  tgaggaggg  acagacagg  ttcagagtt  aggcagacc  300
aatgacgat  ctttccccc  gcagcagag  gatgaggcc  ccccggaat  gagcgggag  360
caaggagag  tttagaaag  ctgagaacc  tgtactcaa  gttgaggag  atgtggacc  420
agtccagag  aaagggaaa  tgcagttcc  cctgggaag  gggaaggct  tgtctttgt  480
gcatcgtac  catgtgcaa  ccctcccag  gacactccc  atgcagaag  cccagggga  540
agacagcaa  cctgaagtc  cctccttgc  catgatgtc  aagcagaca  cagtgttag  600
gtctgagaa  gactctttc  cagtgtcaa  aggagttcc  ttgaacaaa  cagcagaac  660
tacagaaac  ttagataaa  aacaagagg  cccagagaa  tataatctc  gcagtgata  720
atcaaagca  gcctcccaa  gggccctga  tgtgaccat  agtgtcagg  ctgacagat  780
aaagcagca  tcacagaca  taacaaaat  aagcataca  tttgccagc  taccaatcc  840
gaaacctga  gaagtcacg  tcacaaaga  aactgaggc  cagggcaaa  acctaaaat  900
tgaagccca  aaagcgcgc  ctcttctta  gttcactgc  gatgtgggt  atttaaaga  960
acaatctac  aatgagaca  gattgggag  attgccaga  gccgatggg  ccaaagtgg  1020
gccagggaa  aaactaaat  tctctgaaa  tcagattgt  attataact  aagaggaag  1080
ccagaagac  gacaccaaa  aggtaccta  ttctaaaat  caaactgtc  tccctaaat  1140
actgggtga  agccaagga  aacatatcc  caggagtca  agccagacc  tgtcctctc  1200
attagctcc  aagagagct  tgtctcagt  caagcccac  ttagctgag  aactccata  1260
agcaagaag  aacttgact  ccaaggcca  aactgtagg  caccagcaa  gccatgcaa  1320
tatctctga  aaccctgga  agcatcacg  gctcagaat  gatgtgacc  tctctccaa  1380
agatctcaa  gctccaggt  agttcgggc  ccctgtcgt  gttccccct  gaaagaaga  1440
ggaggctga  cagagatgg  aagaaggaa  cttcaatgt  taccttagc  atttgattc  1500
agtggacag  gccattgaa  acacaaggc  tgctgggtg  gcagagcaa  tagttcaca  1560
cgacctccc  accaccagc  tcatcatgt  cttcgtgga  gaggtgtgg  ctgctctcc  1620
gaggtctgt  cacagtgtc  tcaaccgct  ccctccaca  ctcatcaag  agattctgc  1680
ggtggatga  ttcagcacc  aagactacc  gaaagctaa  ttggataaa  acatgtctc  1740
gtttccaaa  gttcggatt  ttcgcctca  ggagagaca  ggcttgatc  gagcaaggc  1800
ggctggggc  cagaatgca  caggtgatg  gctgacatt  ctagactcc  atgtggaat  1860
taatgtggg  tggctggaa  cccttctgg  gagagttta  ttaaataga  agaaagtag  1920
ctgtccagt  attgaagtc  tcaatgaca  ggacatgag  tacatgaca  tggacaact  1980
ccaaagagg  gtcttcacc  ggcccatga  ctttggctg  agaacaatc  ctccagatg  2040
tattgcaaa  aatggaatt  aagaaacag  tataataag  tgcccagtc  tggcaggtg  2100
attattttc  attgacaaa  gttactttt  tgaacttgg  acttatgac  ctggtcttg  2160
tgtttgggg  ggagaaaat  tggagctat  attcaaggt  tggatgtgt  gtggtgaaa  2220
cgagatcat  ccctgttcc  gagtgggcc  catattcag  aatgacaat  cctactcct  2280
ccccaagga  cgcatgaag  cggtggaac  gaatctggt  cgggttgct  aggtctggc  2340
cgatgagta  aaggaactc  tctatggcc  cggggatca  ctcatagac  aagggctgg  2400
tgtgggcaa  ctcacccag  aaagggagt  gcgaaagaa  ctgaagtgc  aaagtttca  2460
gtggtactt  gacaatgtc  ttcccgact  gaaggcgcc  gttgtaaga  ctagtggtg  2520
gtttattaa  ctggccttg  gcaagtgtg  ttccatcaa  aatatcaca  ttgtcctgg  2580
ggactgcga  gggagcagt  agcttcaac  atttaatta  acctgggta  gacttatta  2640
gcatggaga  tggtgtgtg  cgcccatcc  tgataaagg  tccctgacg  tgtacccgt  2700
tgacaacag  aacaacagg  ttaaatggc  gcacagatc  gcatctgcc  ttcatccag  2760
actggtgga  cacattgtt  ttgaaagct  tcagcagtt  ttatgtatg  aagggaatt  2820
ctctcagaa  accctgaaa  tggctgctt  taacccgac  gaaccacaa  aaaagtgga  2880
atttgaaaa  tactacgat  tctaatgag  aatacttta  ctagttaaa  cactagatt  2940
tgtgaaaat  acacaaaaa  ttggtgact  tatttctct  catagtagt  taaattcca  3000
tttaatagc  tttgaatgg  aggcttttg  aaatgacta  atttgaatc  tcaaacaat  3060
actcaggga  agaagttgc  attgggctg  tgttcttca  ctctgggtg  cctttggaa  3120
tgtcttgtg  cccaccctg  attggggtg  atactgcaa  tcttccttc  ggactctca  3180
aggtaacca  aattggaaa  aaagaatga  gtcatgccc  tgactgctg  catggccca  3240
gaatggcgc  aaacccaac  acattctga  ttcaccaaa  tcatctgca  ggattccca  3300
acctggaag  catagctag  tgcacagag  caccacctt  ttgaaagag  tccatgttt  3360
cctggcagt  tagagcagt  tgctcaggt  tccatgact  ctccttttt  ttccatgac  3420
cctcctaat  gggggtctt  atctgaatg  tttcttaat  tgaagctat  gggggggga  3480
ttaatcaaa  aggaagaag  cttaatgta  tt  3512



<210> 875
<211> 930
<212> PRT
<213> Rattus norvegicus
<308> AAC69708
<400> 875

Met Asn Lys Ile Arg Lys Phe Phe Arg Gly Ser Gly Arg Val Leu Ala 
  1               5                  10                  15
Phe Ile Phe Val Ala Ser Val Ile Trp Leu Leu Phe Asp Met Ala Ala 
             20                  25                  30
Leu Arg Leu Ser Phe Ser Glu Ile Asn Thr Gly Ile Leu Lys Glu Asp 
         35                  40                  45
Ile Met Arg Arg Glu Gln Thr Gly Phe Arg Val Glu Ala Asp Gln Met 
     50                  55                  60
Thr Ile Leu Ser Pro Ser Ser Arg Gly Met Arg Pro Pro Arg Asn Gly 
 65                  70                  75                  80
Ala Gly Gly Lys Glu Ser Phe Arg Lys Ala Glu Asn Arg Val Leu Lys 
                 85                  90                  95
Val Glu Glu Asn Val Asp Gln Val Gln Arg Lys Gly Lys Met Gln Phe 
             100                105                110
Leu Leu Gly Arg Gly Lys Ala Val Ser Leu Trp His Arg Thr His Val 
         115                120                125
Gln Thr Leu Pro Val Thr Leu Pro Met Gln Lys Thr Gln Gly Arg Asp 
     130                135                140
Ser Lys Pro Glu Val Ser Ser Leu His Met Met Ser Lys Gln Thr Thr 
 145                150                155                160
Val Leu Gly Ser Glu Lys Asp Ser Phe Thr Val Ser Arg Gly Val Pro 
                 165                170                175
Leu Asn Lys Thr Ala Glu His Thr Glu Thr Leu Asp Lys Lys Gln Glu 
             180                185                190
Ala Pro Glu Asn Tyr Asn Leu Ser Ser Asp Thr Ser Lys Gln Ala Ser 
         195                200                205
Gln Arg Ala Leu Asn Val Thr Ile Ser Val Arg Thr Asp Arg Ser Lys 
     210                215                220
Gln Gln Ser Gln Thr Val Thr Lys Ser Ser Ile Gln Phe Ala Ser Leu 
 225                230                235                240
Pro Ile Leu Lys Pro Glu Glu Val Thr Val Thr Lys Lys Thr Glu Ala 
                 245                250                255
Gln Gly Lys Asp Leu Lys Tyr Glu Ala His Lys Ala Arg Pro Leu Leu 
             260                265                270
Lys Phe Thr Ala Asp Val Gly His Leu Lys Lys Gln Ser Thr Asn Glu 
         275                280                285
Thr Gly Leu Gly Val Leu Pro Glu Ala Asp Gly Ala Lys Val Ala Pro 
     290                295                300
Gly Lys Lys Leu Asn Phe Ser Glu Ser Gln Ile Val Ile Ile Thr Lys 
 305                310                315                320
Glu Glu Gly Gln Lys Thr Asp Thr Lys Glu Val Pro Asn Ser Lys Ile 
                 325                330                335
Gln Thr Val Phe Pro Lys Leu Leu Gly Glu Ser Gln Gly Lys His Ile 
             340                345                350
Pro Arg Ser Gln Ser Gln Thr Leu Ser Ser Pro Leu Ala Pro Lys Arg 
         355                360                365
Ala Val Ser Gln Ser Lys Pro Thr Leu Ala Glu Glu Leu His Thr Ala 
     370                375                380
Arg Ser Asn Leu Thr Ala Lys Ala Thr Thr Val Gly His Gln Gln Ser 
 385                390                395                400
His Ala Asn Ile Ser Glu Asn Pro Gly Lys His His Val Leu Arg Ile 
                 405                410                415
Asp Val Thr Leu Ser Pro Arg Asp Leu Asn Ala Pro Gly Gln Phe Gly 
             420                425                430
Arg Pro Val Val Val Pro Pro Gly Lys Lys Lys Glu Ala Glu Gln Arg 
         435                440                445
Trp Lys Glu Gly Asn Phe Asn Val Tyr Leu Ser Asp Leu Ile Pro Val 
     450                455                460
Asp Arg Ala Ile Glu Asp Thr Arg Pro Ala Gly Cys Ala Glu Gln Leu 
 465                470                475                480
Val His Asn Asp Leu Pro Thr Thr Ser Ile Ile Met Cys Phe Val Asp 
                 485                490                495
Glu Val Trp Ser Ala Leu Leu Arg Ser Val His Ser Val Leu Asn Arg 
             500                505                510
Ser Pro Pro His Leu Ile Lys Glu Ile Leu Leu Val Asp Asp Phe Ser 
         515                520                525
Thr Lys Asp Tyr Leu Lys Ala Asn Leu Asp Lys Tyr Met Ser Gln Phe 
     530                535                540
Pro Lys Val Arg Ile Leu Arg Leu Lys Glu Arg His Gly Leu Ile Arg 
 545                550                555                560
Ala Arg Leu Ala Gly Ala Gln Asn Ala Thr Gly Asp Val Leu Thr Phe 
                 565                570                575
Leu Asp Ser His Val Glu Cys Asn Val Gly Trp Leu Glu Pro Leu Leu 
             580                585                590
Glu Arg Val Tyr Leu Asn Arg Lys Lys Val Ala Cys Pro Val Ile Glu 
         595                600                605
Val Ile Asn Asp Lys Asp Met Ser Tyr Met Thr Val Asp Asn Phe Gln 
     610                615                620
Arg Gly Val Phe Thr Trp Pro Met Asn Phe Gly Trp Arg Thr Ile Pro 
 625                630                635                640
Pro Asp Val Ile Ala Lys Asn Gly Ile Lys Glu Thr Asp Ile Ile Arg 
                 645                650                655
Cys Pro Val Met Ala Gly Gly Leu Phe Ser Ile Asp Lys Ser Tyr Phe 
             660                665                670
Tyr Glu Leu Gly Thr Tyr Asp Pro Gly Leu Asp Val Trp Gly Gly Glu 
         675                680                685
Asn Met Glu Leu Ser Phe Lys Val Trp Met Cys Gly Gly Glu Ile Glu 
     690                695                700
Ile Ile Pro Cys Ser Arg Val Gly His Ile Phe Arg Asn Asp Asn Pro 
 705                710                715                720
Tyr Ser Phe Pro Lys Asp Arg Met Lys Thr Val Glu Arg Asn Leu Val 
                 725                730                735
Arg Val Ala Glu Val Trp Leu Asp Glu Tyr Lys Glu Leu Phe Tyr Gly 
             740                745                750
His Gly Asp His Leu Ile Asp Gln Gly Leu Asp Val Gly Asn Leu Thr 
         755                760                765
Gln Gln Arg Glu Leu Arg Lys Lys Leu Lys Cys Gln Ser Phe Lys Trp 
     770                775                780
Tyr Leu Asp Asn Val Phe Pro Asp Leu Lys Ala Pro Val Val Arg Ala 
 785                790                795                800
Ser Gly Val Phe Ile Asn Leu Ala Leu Gly Lys Cys Val Ser Ile Lys 
                 805                810                815
Asn Ile Thr Val Val Leu Glu Asp Cys Asp Gly Ser Ser Glu Leu Gln 
             820                825                830
Gln Phe Asn Tyr Thr Trp Val Arg Leu Ile Lys His Gly Glu Trp Cys 
         835                840                845
Val Ala Pro Ile Pro Asp Lys Gly Ser Leu Thr Leu Tyr Pro Cys Asp 
     850                855                860
Asn Arg Asn Asn Arg Leu Lys Trp Leu His Arg Ser Ala Ser Ala Phe 
 865                870                875                880
His Pro Glu Leu Val Asp His Ile Val Phe Glu Ser Tyr Gln Gln Leu 
                 885                890                895
Leu Cys Met Glu Gly Asn Phe Ser Gln Lys Thr Leu Lys Leu Ala Ala 
             900                905                910
Cys Asn Pro Thr Glu Pro Gln Gln Lys Trp Lys Phe Glu Lys Tyr Tyr 
         915                920                925
Asp Val 
     930



<210> 876
<211> 2007
<212> DNA
<213> Homo sapiens
<308> AJ245539
<400> 876

gccgagggt  ttccttttc  taagttcac  gtcaattca  atcgcttaa  gaagcaatc  60
attaatgag  cacctttgg  aagtttgtc  aaggatgat  gagctagag  ggctcatgg  120
aagaaactc  atttctctg  aagccatct  gtgattata  ccaaagagg  agagcaaaa  180
gcagacccc  aagaggtct  taattctaa  accaaaaca  tatttccta  agtattggg  240
aaaagccaa  gtaaacaca  ttccaggaa  agaagtgag  tgtcttcct  ttcacttgc  300
ccacataga  tgccactgt  ccaaactaa  catgcttta  ctggagggc  agagccagc  360
aaaatcaac  taactgcca  agccccctc  acagaatac  accagagtc  tataaaagc  420
cttttacct  aagacagtg  aacgcacca  gtgttaaga  ttgatgtga  actttctcc  480
agggacccc  aagctccag  gcagtttgg  cgtcctgta  ttgtccccc  tggaaagga  540
aaggaggca  aaagaagat  gaaagaagg  aacttcaat  tctacctta  cgatttgat  600
ccagtggat  gagccattg  agacaccag  cctgctgga  gtgcagagc  gctagttca  660
aataacctc  caaccacca  tgtcatcat  tgctttgtg  atgaagtgt  gtccactct  720
ctgagatct  ttcacagtg  catcaatcg  tctcctcca  acctcatca  ggagattct  780
ctggtagat  acttcagca  caaagacta  ctaaaagat  atttggata  atacatgtc  840
cagtttcca  aagttcgga  tcttcgcct  aaagagaga  atggcttaa  aagggccag  900
ctggcagga  cacagaatg  aacaggtga  gtgttgaca  ttttagatt  tcatgtgga  960
tgtaacgtt  gttggttgg  acctcttct  gaaagagtt  atttaagta  aaagaaagt  1020
gcctgtcca  taatcgaag  catcaatga  aaggatatg  gttacatga  agtggataa  1080
tttcaaaga  gcatctttg  gtggcccat  aactttggt  ggagaacaa  tcctccaga  1140
gtcattgca  aaaacagaa  taaagaaac  gatacaata  ggtgccctg  catggctgg  1200
ggattgttt  ctattgaca  aagttactt  tttgaactt  gaacatacg  ccctggcct  1260
gatgtttgg  gtggggaaa  tatggagct  tcattcaag  tgtggatgt  tggtggtga  1320
attgagatc  ttccctgct  ccgagtggg  catatattc  gaaatgaca  tccatattc  1380
ttccccaaa  accggatga  gacagtgga  cggaacttg  tgcgggttg  cgaggtctg  1440
ctggatgag  ataaggagc  gttctatgg  catggagac  acctcatcg  ccaagggct  1500
gatgttggc  acctcaccc  gcaaaggga  ctgcgaaag  aactgaagt  caaaagttt  1560
aaatggtac  tggagaatg  ctttcctga  ttaagggct  ccattgtga  agctagtgg  1620
gtgcttatt  atgtggctt  gggtaaatg  atttccatt  aaaacacta  agtcattct  1680
gaagactgc  atgggagca  agagcttca  caatttaat  acacctggt  aagacttat  1740
aaatgtgga  aatggtgta  agcccccat  cctgataaa  gagccgtaa  gctgcaccc  1800
tgtgataac  gaaacaaag  gctaaaatg  ctgcataaa  caacatcag  ctttcatcc  1860
gaactggtg  atcacattg  ttttgaaaa  aatcagcaa  tattatgct  ggaaggaaa  1920
ttttctcaa  agatcctga  agtagctgc  tgtgaccca  tgaagccat  tcaaaagtg  1980
aaatttgaa  aatattatg  agcctga  2007



<210> 877
<211> 610
<212> PRT
<213> Homo sapiens
<308> AAF15313
<400> 877

Gln Lys Ala Asp Pro Lys Glu Val Ser Asn Ser Lys Thr Lys Thr Ile 
  1               5                  10                  15
Phe Pro Lys Val Leu Gly Lys Ser Gln Ser Lys His Ile Ser Arg Asn 
             20                  25                  30
Arg Ser Glu Met Ser Ser Ser Ser Leu Ala Pro His Arg Val Pro Leu 
         35                  40                  45
Ser Gln Thr Asn His Ala Leu Thr Gly Gly Leu Glu Pro Ala Lys Ile 
     50                  55                  60
Asn Ile Thr Ala Lys Ala Pro Ser Thr Glu Tyr Asn Gln Ser His Ile 
 65                  70                  75                  80
Lys Ala Leu Leu Pro Glu Asp Ser Gly Thr His Gln Val Leu Arg Ile 
                 85                  90                  95
Asp Val Thr Leu Ser Pro Arg Asp Pro Lys Ala Pro Gly Gln Phe Gly 
             100                105                110
Arg Pro Val Val Val Pro His Gly Lys Glu Lys Glu Ala Glu Arg Arg 
         115                120                125
Trp Lys Glu Gly Asn Phe Asn Val Tyr Leu Ser Asp Leu Ile Pro Val 
     130                135                140
Asp Arg Ala Ile Glu Asp Thr Arg Pro Ala Gly Cys Ala Glu Gln Leu 
 145                150                155                160
Val Xaa Asn Asn Leu Pro Thr Thr Ser Val Ile Met Cys Phe Val Asp 
                 165                170                175
Glu Val Trp Ser Thr Leu Leu Arg Ser Val His Ser Val Ile Asn Arg 
             180                185                190
Ser Pro Pro His Leu Ile Lys Glu Ile Leu Leu Val Asp Asp Phe Ser 
         195                200                205
Thr Lys Asp Tyr Leu Lys Asp Asn Leu Asp Lys Tyr Met Ser Gln Phe 
     210                215                220
Pro Lys Val Arg Ile Leu Arg Leu Lys Glu Arg His Gly Leu Ile Arg 
 225                230                235                240
Ala Arg Leu Ala Gly Ala Gln Asn Ala Thr Gly Asp Val Leu Thr Phe 
                 245                250                255
Leu Asp Ser His Val Glu Cys Asn Val Gly Trp Leu Glu Pro Leu Leu 
             260                265                270
Glu Arg Val Tyr Leu Ser Arg Lys Lys Val Ala Cys Pro Val Ile Glu 
         275                280                285
Val Ile Asn Asp Lys Asp Met Ser Tyr Met Thr Val Asp Asn Phe Gln 
     290                295                300
Arg Gly Ile Phe Val Trp Pro Met Asn Phe Gly Trp Arg Thr Ile Pro 
 305                310                315                320
Pro Asp Val Ile Ala Lys Asn Arg Ile Lys Glu Thr Asp Thr Ile Arg 
                 325                330                335
Cys Pro Val Met Ala Gly Gly Leu Phe Ser Ile Asp Lys Ser Tyr Phe 
             340                345                350
Phe Glu Leu Gly Thr Tyr Asp Pro Gly Leu Asp Val Trp Gly Gly Glu 
         355                360                365
Asn Met Glu Leu Ser Phe Lys Val Trp Met Cys Gly Gly Glu Ile Glu 
     370                375                380
Ile Ile Pro Cys Ser Arg Val Gly His Ile Phe Arg Asn Asp Asn Pro 
 385                390                395                400
Tyr Ser Phe Pro Lys Asp Arg Met Lys Thr Val Glu Arg Asn Leu Val 
                 405                410                415
Arg Val Ala Glu Val Trp Leu Asp Glu Tyr Lys Glu Leu Phe Tyr Gly 
             420                425                430
His Gly Asp His Leu Ile Asp Gln Gly Leu Asp Val Gly Asn Leu Thr 
         435                440                445
Gln Gln Arg Glu Leu Arg Lys Lys Leu Lys Cys Lys Ser Phe Lys Trp 
     450                455                460
Tyr Leu Glu Asn Val Phe Pro Asp Leu Arg Ala Pro Ile Val Arg Ala 
 465                470                475                480
Ser Gly Val Leu Ile Asn Val Ala Leu Gly Lys Cys Ile Ser Ile Glu 
                 485                490                495
Asn Thr Thr Val Ile Leu Glu Asp Cys Asp Gly Ser Lys Glu Leu Gln 
             500                505                510
Gln Phe Asn Tyr Thr Trp Leu Arg Leu Ile Lys Cys Gly Glu Trp Cys 
         515                520                525
Ile Ala Pro Ile Pro Asp Lys Gly Ala Val Arg Leu His Pro Cys Asp 
     530                535                540
Asn Arg Asn Lys Gly Leu Lys Trp Leu His Lys Ser Thr Ser Val Phe 
 545                550                555                560
His Pro Glu Leu Val Asn His Ile Val Phe Glu Asn Asn Gln Gln Leu 
                 565                570                575
Leu Cys Leu Glu Gly Asn Phe Ser Gln Lys Ile Leu Lys Val Ala Ala 
             580                585                590
Cys Asp Pro Val Lys Pro Tyr Gln Lys Trp Lys Phe Glu Lys Tyr Tyr 
         595                600                605
Glu Ala 
     610



<210> 878
<211> 1421
<212> DNA
<213> Rattus norvegicus
<308> AF051425
<400> 878

ctactgctg  tgctgctac  gctgccgct  tgtgcaggg  gcattcact  tagggacaa  60
gggacagtt  ggacagtta  gacagcaag  cgggacctt  gagtatctt  ttctccgtc  120
tcagtcatg  cagagaact  ggacaaagt  cctatcacc  tggtaggac  tgaagacgt  180
gagttttgc  gtcccccgg  atatgccac  gtgaccgtg  agccctccg  gagccctac  240
cggctgctc  aggtgggag  tgtggttct  atttctggc  cggtgctgc  gctcttcgg  300
gccattggg  ccttctact  ctggaaggg  aatgacaat  acatttaca  cgtccatta  360
accatgagt  tcaatggga  actacaaga  gcgtccatg  agatagatg  tgccaacaa  420
ttggagacc  ttaaaatgg  aagcggagc  gaggaagcg  ttgaagtta  tgatttcca  480
aatggcatc  ctgggatcc  ttttgctgg  ggagagaag  gctacatca  agcacaggt  540
aaggctcgc  tccctgagg  cagcactgg  accaagcag  gcatctctg  actggaagg  600
aagatcatg  cagtcaaat  tgaagagaa  tctctgatt  gggtggccg  ggaccagcc  660
gtaaaggac  acagcttcc  gagttctaa  atcctcgaa  tctgtggcg  cctgcctat  720
ttctggctt  agcccatgt  tccgaaaga  atcccaaga  agagaagag  agtagtgag  780
agcagtgct  cctctacca  aaggagacc  cacagcgaa  ctcgaggca  cgcaggccc  840
ggaagactg  gtaacagaa  cagacccag  gttcaggat  acgaagaac  tttcaaccc  900
gacaatcct  accaccagc  ggaaggaga  agcatgacc  ttgacccta  actggatca  960
gaaggaatc  gctgtatag  gtgcagacg  agctacacc  actgccaga  gatctgcga  1020
ccgctggga  gttactacc  gtggcctta  aattaccaa  ggtgtcgct  agcctgcag  1080
gtggtcatg  cgtgcagct  gtgggttgc  cgcatcttg  gcatggtgt  aatccattt  1140
atctatcag  actgccaag  aagaattag  acgagagtt  agaaccaaa  aaccatgcc  1200
agggaccgc  aagtatttt  tactcaacc  gaataacgt  atcctaaac  ctgcagcag  1260
accttggtt  tgcaccgct  tgtgcaaat  tactgaaag  gtagtttta  gtctacagt  1320
actatccct  tactatttg  tttaccaat  aagtctact  caagtcttt  aaagctact  1380
ttgaaataa  catgaagtt  tttacaaaa  aaaaaaaaa  a  1421



<210> 879
<211> 334
<212> PRT
<213> Rattus norvegicus
<308> O70367
<400> 879

Met Thr Glu Asn Ser Asp Lys Val Pro Ile Thr Met Val Gly Pro Glu 
  1               5                  10                  15
Asp Val Glu Phe Cys Ser Pro Pro Ala Tyr Ala Thr Val Thr Val Lys 
             20                  25                  30
Pro Ser Gly Ser Pro Thr Arg Leu Leu Lys Val Gly Ala Val Val Leu 
         35                  40                  45
Ile Ser Gly Ala Val Leu Leu Leu Phe Gly Ala Ile Gly Ala Phe Tyr 
     50                  55                  60
Phe Trp Lys Gly Asn Asp Asn His Ile Tyr Asn Val His Tyr Thr Met 
 65                  70                  75                  80
Ser Ile Asn Gly Arg Leu Gln Asp Ala Ser Met Glu Ile Asp Ala Ala 
                 85                  90                  95
Asn Asn Leu Glu Thr Phe Lys Met Gly Ser Gly Ala Glu Glu Ala Ile 
             100                105                110
Glu Val Asn Asp Phe Gln Asn Gly Ile Thr Gly Ile Arg Phe Ala Gly 
         115                120                125
Gly Glu Lys Cys Tyr Ile Lys Ala Gln Val Lys Ala Arg Ile Pro Glu 
     130                135                140
Val Ser Thr Gly Thr Lys Gln Ser Ile Ser Glu Leu Glu Gly Lys Ile 
 145                150                155                160
Met Pro Val Lys Tyr Glu Glu Asn Ser Leu Ile Trp Val Ala Val Asp 
                 165                170                175
Gln Pro Val Lys Asp Asn Ser Phe Leu Ser Ser Lys Ile Leu Glu Phe 
             180                185                190
Cys Gly Asp Leu Pro Ile Phe Trp Leu Lys Pro Met Tyr Pro Lys Glu 
         195                200                205
Ile Pro Arg Glu Arg Arg Glu Val Val Arg Ser Ser Ala Pro Ser Thr 
     210                215                220
Thr Arg Arg Pro His Ser Glu Pro Arg Gly Asn Ala Gly Pro Gly Arg 
 225                230                235                240
Leu Ser Asn Arg Thr Arg Pro Ser Val Gln Asp Asp Glu Glu Pro Phe 
                 245                250                255
Asn Pro Asp Asn Pro Tyr His Gln Gln Glu Gly Glu Ser Met Thr Phe 
             260                265                270
Asp Pro Arg Leu Asp His Glu Gly Ile Cys Cys Ile Glu Cys Arg Arg 
         275                280                285
Ser Tyr Thr His Cys Gln Lys Ile Cys Glu Pro Leu Gly Gly Tyr Tyr 
     290                295                300
Pro Trp Pro Tyr Asn Tyr Gln Gly Cys Arg Ser Ala Cys Arg Val Val 
 305                310                315                320
Met Pro Cys Ser Trp Trp Val Ala Arg Ile Leu Gly Met Val 
                 325                330



<210> 880
<211> 363
<212> DNA
<213> Homo sapiens
<308> AB005999
<400> 880

gaagtggta  gaaaaattg  tccaactac  acaaaaaga  cacacagtg  accacggag  60
aacccaggc  ctggaagac  gaataatga  accagaccc  gtgttcaag  ggactcaca  120
gccttcaat  ctgataatc  ttatcatca  caggaaggg  aaagcatga  attcgaccc  180
agactggat  acgaaggaa  ctgttgtat  gaatgtagg  ggagctaca  ccactgcca  240
aagatctgt  aacccctgg  gggctatta  ccatggcct  ataattatc  aggctgccg  300
tcggcctgc  gagtcatca  gccatgtag  tggtgggtg  cccgtatct  gggcatggt  360
tga  363



<210> 881
<211> 334
<212> PRT
<213> Homo sapiens
<308> O75829
<400> 881

Met Thr Glu Asn Ser Asp Lys Val Pro Ile Ala Leu Val Gly Pro Asp 
  1               5                  10                  15
Asp Val Glu Phe Cys Ser Pro Pro Ala Tyr Ala Thr Leu Thr Val Lys 
             20                  25                  30
Pro Ser Ser Pro Ala Arg Leu Leu Lys Val Gly Ala Val Val Leu Ile 
         35                  40                  45
Ser Gly Ala Val Leu Leu Leu Phe Gly Ala Ile Gly Ala Phe Tyr Phe 
     50                  55                  60
Trp Lys Gly Ser Asp Ser His Ile Tyr Asn Val His Tyr Thr Met Ser 
 65                  70                  75                  80
Ile Asn Gly Lys Leu Gln Asp Gly Ser Met Glu Ile Asp Ala Gly Asn 
                 85                  90                  95
Asn Leu Glu Thr Phe Lys Met Gly Ser Gly Ala Glu Glu Ala Ile Ala 
             100                105                110
Val Asn Asp Phe Gln Asn Gly Ile Thr Gly Ile Arg Phe Ala Gly Gly 
         115                120                125
Glu Lys Cys Tyr Ile Lys Ala Gln Val Lys Ala Arg Ile Pro Glu Val 
     130                135                140
Gly Ala Val Thr Lys Gln Ser Ile Ser Ser Lys Leu Glu Gly Lys Ile 
 145                150                155                160
Met Pro Val Lys Tyr Glu Glu Asn Ser Leu Ile Trp Val Ala Val Asp 
                 165                170                175
Gln Pro Val Lys Asp Asn Ser Phe Leu Ser Ser Lys Val Leu Glu Leu 
             180                185                190
Cys Gly Asp Leu Pro Ile Phe Trp Leu Lys Pro Thr Tyr Pro Lys Glu 
         195                200                205
Ile Gln Arg Glu Arg Arg Glu Val Val Arg Lys Ile Val Pro Thr Thr 
     210                215                220
Thr Lys Arg Pro His Ser Gly Pro Arg Ser Asn Pro Gly Ala Gly Arg 
 225                230                235                240
Leu Asn Asn Glu Thr Arg Pro Ser Val Gln Glu Asp Ser Gln Ala Phe 
                 245                250                255
Asn Pro Asp Asn Pro Tyr His Gln Gln Glu Gly Glu Ser Met Thr Phe 
             260                265                270
Asp Pro Arg Leu Asp His Glu Gly Ile Cys Cys Ile Glu Cys Arg Arg 
         275                280                285
Ser Tyr Thr His Cys Gln Lys Ile Cys Glu Pro Leu Gly Gly Tyr Tyr 
     290                295                300
Pro Trp Pro Tyr Asn Tyr Gln Gly Cys Arg Ser Ala Cys Arg Val Ile 
 305                310                315                320
Met Pro Cys Ser Trp Trp Val Ala Arg Ile Leu Gly Met Val 
                 325                330



<210> 882
<211> 6402
<212> DNA
<213> Rattus norvegicus
<308> AF051561
<400> 882

tgtgaggca  cggcgctgc  actctctct  ccccggctc  ttagtggga  cgccggcca  60
ggacccgag  cgcgctgta  gcagcgtcc  cccgcccgc  ccgcaggtc  ccgagcgtc  120
ggcggcgat  gagcccggg  ccgcggcgc  ctcgtctgg  gccccgcgg  ccgcccggg  180
tggggacgc  ccgctgact  ccgccgggg  ggacctgcc  ggcacggcc  tactctccg  240
tcgagagga  gctaccgct  ggagccagg  cggcggcgg  gtgcgcgga  agggaaccc  300
ggccgctgg  gatgggctg  gcaaacctc  ggggcccac  cccagccag  gccgcttcc  360
ggtggaccc  gtttccgag  acgccgggc  ggccgcggc  gctgcagct  cagcggcgg  420
tgcggcggc  gccggggca  cgggcaagg  gacccccgc  gctgggaaa  ccggcactg  480
gagcggcgt  gccaagggc  gcgaggaag  caagggccg  ttccgcgtg  acttcgtgg  540
cccggctgc  tcctcgtcg  cggacgaca  cctgtcgga  gcggcggga  tcggtggcg  600
cgggcccaa  gtgagctcc  agaacggcg  ggacacggt  ctgagcgag  gcagcagcc  660
gcactcggg  ggtggcagt  gacaccacc  gcagtacta  tatgacacc  acaccaaca  720
ttactacct  cgcaccttc  gccacaaca  catggacgc  gtgcccagg  tcgaccact  780
ccggcacac  gccgcgcag  tgggcgaga  gctgctccg  cccagcctg  gagagttcc  840
cgatgagct  gaaaaggaa  cttttgagg  tggttttgc  aatggagaa  aaagtactc  900
aaccagaga  gctgtggtc  catacactg  cgaaagtaa  ggagttgta  agtttggct  960
gatcaaggg  gttttagta  gatgtatgt  gaatatttg  ggtgtgatg  tctttattc  1020
attgtcatg  attgtgggt  aggctggaa  aggtctctc  gttcttgta  tagcaatgg  1080
cactgttgt  acaaccatc  caggattgt  tacttcagc  atagctacc  atggattcg  1140
gagaggagg  ggagcatac  atttaatct  tagaagtct  gggccagaa  ttggcggtg  1200
gattggctt  atcttcgct  ttcccaatg  agtggcagt  gctatgtat  ttgttggat  1260
cgcagagac  gtagtggag  tgcttaagg  acattccat  cttatgata  atgaaatca  1320
tgacatccg  attattgga  ccattacag  ggtggttct  ctgggcatc  cagtggccg  1380
aatggagtg  gaagcaaag  ctcagatcg  ccttctggt  attcttctt  tggccatcg  1440
tgacttcgt  ataggaaca  ttatctcac  ggacagcaa  aagcccaag  gtttctttg  1500
ctataaatc  gaaatattt  gtgagaact  tggaccgga  tttcgagaa  aagagactt  1560
cttttctgt  ttcgccatc  tttttcctg  tgcaactgg  attctagct  gggcgaaca  1620
ctcgggtga  cttgcagat  ctcagtcag  catacccaa  ggaacgctc  tagccattt  1680
gattacgac  gtggtttac  taggaatcg  agtgtctgt  ggttcttgt  ttgtccggg  1740
tgccactgg  aacgttaat  acaccatta  aacagagct  actaactgt  cttctgcag  1800
ctgcaaatt  aactttgac  tttcctact  tgaaagcaa  acctgttct  atgggctaa  1860
gaacaactt  caggtgatg  gcatggtgt  aggatttgc  cccctgatc  ctgcgggta  1920
cttttcagc  acactctca  cagcactgg  atctcttgt  agtgctccc  aaatatttc  1980
ggctctatg  aaggacaat  tctacccag  tttccagat  tttgcgaaa  gttatggaa  2040
aaataatga  cctcttcgt  gttacatct  aacattctt  attgcactt  gattcatct  2100
aattgctga  ttgaatgtc  ttgctccaa  tatctctaa  ttctttctc  catcatacg  2160
cttaatcaa  ttttctgta  tccatgcgt  acttgcaaa  tctccaggg  ggcgtcctg  2220
gttcaagta  tacaacatg  ggatctccc  tactggagc  attctctgc  gcatagtga  2280
gttcgtcat  aactggtgg  ctgcactgc  cacatatgt  atagttctt  gactgtaca  2340
ttatgtcac  tacaaaaag  cagatgtga  ctggggatc  tccacacaa  cgctgactt  2400
cctcagcgc  ctgcagcat  caatccgtc  ttccggggt  gaggaccat  tgaaaaact  2460
caggccaca  tgtcttgta  tgacaggtt  tccaaactc  cggcctgct  tactgcatc  2520
tgttcatga  ttcacgaaa  atgttggtt  aatgatctg  ggccatgtg  atatgggtc  2580
ccgaagaca  gctatgaaa  agatgtcca  tgatcaagc  aaatatcag  gatggctca  2640
taaaaacaa  atgaaggct  tctacgctc  ggttcacgc  gatgacttg  gggaaggtg  2700
acagtacct  atgcaggct  ctggacttg  tcgtatgaa  ccaaacaca  ttgtcctcg  2760
atttaagaa  gattggtta  aagcagata  gagggatgt  gatatgtat  taaacttat  2820
tcatgatgc  tttgacata  agtatggag  tgtggtcat  cgcctaaag  aaggactgg  2880
tatatcaca  ctccaagga  aagaagaat  attgtcatc  caagaaaag  cacctggta  2940
caaggatgt  gtagtaaat  tggactaca  taagaagtc  gatcaagat  ctttcaaag  3000
atctggtga  aaacctatt  cacagaaag  tgaggaaga  gatggcaag  cttcaactc  3060
gccactgtt  aaaaaagaa  ccaagggcc  cgtggcacc  ttaaatgta  ctgaccaaa  3120
gcttcttga  gctagcaca  agtttcaga  aaaacaagg  aagaatact  tagatgtct  3180
gtggctttt  gatgatgga  gtttgacct  gttgatacc  tatcttctg  caaccaaga  3240
aaagtggaa  gattgtaag  tccgagtat  cattggtgg  aagataaac  gaatagacc  3300
tgaccggag  gcgatggct  ctttactca  taaattccg  atagacttc  ccgatatca  3360
ggtcctagg  gacatcaac  ccaaaccaa  aaaggaaaa  atcgtcgct  ttgatgaca  3420
gattgagcc  tacagactt  acgaggatg  taaagagca  gatattgca  acaaaatga  3480
agaggatga  ccctggcgc  tcacagaca  cgagctgga  ctctacaag  ccaagacat  3540
tcggcagat  aggttaaat  aattattaa  ggagcattc  agcacagct  atattattg  3600
catgagtct  ccagttgcc  ggaagggtg  tgtgtccag  gcgctgtac  tggcttggt  3660
agaagctct  tctaaggac  tgccaccaa  cctgctggt  cgtgggaat  atcagagcg  3720
ccttacctt  tactcttaa  tgtcctgcc  catggactc  ctctaagaa  ggtacttca  3780
tgcctagtc  gagtgactg  atcgtcagc  acaccgcag  atcacagtg  cgaactggg  3840
ctttgtttc  ctacttcat  ctttgaaag  acatggaca  gttgctcca  tgatagatc  3900
gtggagact  cggttttag  ctactccag  tctcagtct  atgactgct  attcttcct  3960
gttggactg  agttcttga  agtaaagtt  tcctttgct  cttgacagc  ataagagtg  4020
gttattttt  attgctgaa  ggagtacat  agcctttag  cttgaggtg  cttctgaaa  4080
taaccaaat  tcatccata  atctatcgt  ttttgtaca  ttatagaat  ttaaactct  4140
ccttcagac  ttattttta  ttctaatct  tgtcatcct  agtggacac  gcttgtctc  4200
tcccattga  cagttagtg  tgagagctg  gtgtttcgt  ttacttttg  aaaagcgtt  4260
gttggatac  gaagagggt  ggacaagct  ataaaatat  tggagaaag  atccaaaaa  4320
ggagcccaa  gttaggttt  tatgaatag  tacttagag  tagggaaga  aggcccgaa  4380
accgtttct  tctctcaat  agagttatc  attatttct  ttaaatcat  gagatgact  4440
acgatctac  cagtacttc  tttataaca  aaaaaaaaa  aatcacatt  ttttaaagc  4500
aaaccttga  gtcatttgt  ttgttttta  aagatctct  ttaatttag  atttcctct  4560
aaatgggag  gacttttaa  acatgctaa  tggtatttt  cgaggaaat  tagacaaag  4620
attgccatt  actagagca  ttcaataaa  actatgggg  tttcactat  ctatcgcat  4680
ctttattta  aaagaaaga  gacaatgtt  tcaatggtt  aatggacca  tgttttctt  4740
gtgaaatgg  tttaggctt  atttattca  gtatcaaga  catttagtc  taatacact  4800
aggtttgaa  agattattc  gaacattga  atttaatcc  ttcttaata  tttaaaact  4860
gcgttaaag  aaactgcca  tttgtgcat  tgaccttgt  gtctgcaag  gcacttgac  4920
gtgagcgtg  acacctgcg  tgtcctgaa  gctttatac  cagtcgtta  tgtgaagtg  4980
ctaagttca  ggaaggatc  tctaaacat  tcaagggat  catgtccac  tgtctgtct  5040
tgtgtatgt  ttgcataca  aggtgcata  gtgtatatg  aatgaaatt  atgttgcca  5100
tgtttcaga  tttaaagcg  tcatgattt  gtaggttac  gattttgtt  ttgttgttg  5160
tttagtttt  tcttttctt  tttaagtaa  cattcaagt  agatcaaga  attacagat  5220
tcatggagg  caaagacaa  tgaaagaac  tcgtgtagc  ttgtacagt  atccagtta  5280
gtaaagtag  tgatctgta  gtttcagtg  agaacatag  gcagacttt  atcatctta  5340
gggaaatgt  agaaaagca  ttcagtagt  tagtacttg  gctccatga  aacagactg  5400
gttaatacc  gctggatat  ttctcgttt  cactcagaa  attaaagaa  acaaggtta  5460
gtgattttt  ccaagttct  cttacatta  aatataata  tgttccatt  attgtaaat  5520
ttgcagagt  tagggcagt  tagaagaat  atattagca  accatatca  gtgtggatc  5580
tctgaatgg  tactagggc  tgggctgaa  gctgctatc  tgaaatgta  acagctaga  5640
ttgcctttt  tttttaaag  ttttccctc  ttcaggaaa  ttcattgtg  tctgtacta  5700
agaaactaa  tgtcataca  catacgtgt  tgttcaaag  acataaaat  gatctcaac  5760
cacctaaca  ggagggtgg  gacactgtg  agtgatgcc  gcagcagct  tctactctt  5820
aaaaccgcc  tccgtcgtc  gctaacacg  gctgccagg  cagacgttc  caaggttgc  5880
gtagtactc  aaaacgaaa  ttctcaatg  ttaattctt  gacatctag  tagtattag  5940
gctgttttc  ttttacgct  tttggatta  ttggatgcc  aattatgtt  tagtcctaa  6000
cattgataa  aacttaaaa  tacgcagtg  catttgagc  cattcttgg  ataagttaa  6060
aacttgagt  cgttcaaag  gaacgtcgt  gatgattaa  ggttcacta  atcagatat  6120
catttgtct  atcttttcc  tcctgcttt  ttttccttc  ctcttctca  atggctctc  6180
tgacgtgtg  gtggtttgt  ttgttttgt  tttttaaga  tatggaaat  atttaatga  6240
ttgagctcc  gtgatgatc  gctaagttt  aaaatgtaa  attttgata  tactgtact  6300
tacctgtcc  aaatgcttt  gtaatgttt  aaccccgag  attgcagtt  ctgctccgt  6360
cagaggtta  tgcaataaa  gaagtggaa  cattaaaac  tt  6402



<210> 883
<211> 1203
<212> PRT
<213> Rattus norvegicus
<308> AAC27557
<400> 883

Met Glu Pro Gly Pro Ala Ala Pro Ser Ser Gly Ala Pro Arg Pro Ala 
  1               5                  10                  15
Arg Asp Gly Asp Ala Pro Leu Thr Ala Ala Gly Val Asp Leu Pro Gly 
             20                  25                  30
Thr Ala Val Leu Ser Gly Arg Glu Asp Ala Thr Ala Gly Ser Gln Ala 
         35                  40                  45
Gly Gly Gly Val Arg Gly Glu Gly Thr Pro Ala Ala Gly Asp Gly Leu 
     50                  55                  60
Gly Lys Pro Leu Gly Pro Thr Pro Ser Gln Ser Arg Phe Gln Val Asp 
 65                  70                  75                  80
Pro Val Ser Glu Asn Ala Gly Arg Ala Ala Ala Ala Ala Ala Ala Ala 
                 85                  90                  95
Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly Lys Glu Thr Pro Ala Ala 
             100                105                110
Gly Lys Ala Gly Thr Glu Ser Gly Val Ala Lys Gly Ser Glu Glu Ala 
         115                120                125
Lys Gly Arg Phe Arg Val Asn Phe Val Asp Pro Ala Ala Ser Ser Ser 
     130                135                140
Ala Asp Asp Ser Leu Ser Asp Ala Ala Gly Val Gly Gly Asp Gly Pro 
 145                150                155                160
Asn Val Ser Ser Gln Asn Gly Gly Asp Thr Val Leu Ser Glu Gly Ser 
                 165                170                175
Ser Leu His Ser Gly Gly Gly Ser Gly His His Gln Gln Tyr Tyr Tyr 
             180                185                190
Asp Thr His Thr Asn Thr Tyr Tyr Leu Arg Thr Phe Gly His Asn Thr 
         195                200                205
Met Asp Ala Val Pro Arg Ile Asp His Tyr Arg His Thr Ala Ala Gln 
     210                215                220
Leu Gly Glu Lys Leu Leu Arg Pro Ser Leu Gly Glu Phe His Asp Glu 
 225                230                235                240
Leu Glu Lys Glu Pro Phe Glu Asp Gly Phe Ala Asn Gly Glu Glu Ser 
                 245                250                255
Thr Pro Thr Arg Asp Ala Val Val Thr Tyr Thr Ala Glu Ser Lys Gly 
             260                265                270
Val Val Lys Phe Gly Trp Ile Lys Gly Val Leu Val Arg Cys Met Leu 
         275                280                285
Asn Ile Trp Gly Val Met Leu Phe Ile Arg Leu Ser Trp Ile Val Gly 
     290                295                300
Gln Ala Gly Ile Gly Leu Ser Val Leu Val Ile Ala Met Ala Thr Val 
 305                310                315                320
Val Thr Thr Ile Thr Gly Leu Ser Thr Ser Ala Ile Ala Thr Asn Gly 
                 325                330                335
Phe Val Arg Gly Gly Gly Ala Tyr Tyr Leu Ile Ser Arg Ser Leu Gly 
             340                345                350
Pro Glu Phe Gly Gly Ala Ile Gly Leu Ile Phe Ala Phe Pro Asn Ala 
         355                360                365
Val Ala Val Ala Met Tyr Val Val Gly Phe Ala Glu Thr Val Val Glu 
     370                375                380
Leu Leu Lys Glu His Ser Ile Leu Met Ile Asp Glu Ile Asn Asp Ile 
 385                390                395                400
Arg Ile Ile Gly Ala Ile Thr Val Val Val Leu Leu Gly Ile Ser Val 
                 405                410                415
Ala Gly Met Glu Trp Glu Ala Lys Ala Gln Ile Val Leu Leu Val Ile 
             420                425                430
Leu Leu Leu Ala Ile Ala Asp Phe Val Ile Gly Thr Phe Ile Ser Leu 
         435                440                445
Asp Ser Lys Lys Pro Lys Gly Phe Phe Gly Tyr Lys Ser Glu Ile Phe 
     450                455                460
Ser Glu Asn Phe Gly Pro Asp Phe Arg Glu Glu Glu Thr Phe Phe Ser 
 465                470                475                480
Val Phe Ala Ile Phe Phe Pro Ala Ala Thr Gly Ile Leu Ala Gly Ala 
                 485                490                495
Asn Ile Ser Gly Asp Leu Ala Asp Pro Gln Ser Ala Ile Pro Lys Gly 
             500                505                510
Thr Leu Leu Ala Ile Leu Ile Thr Thr Val Val Tyr Ile Gly Ile Ala 
         515                520                525
Val Ser Val Gly Ser Cys Val Val Arg Asp Ala Thr Gly Asn Val Asn 
     530                535                540
Asp Thr Ile Thr Thr Glu Leu Thr Asn Cys Thr Ser Ala Ala Cys Lys 
 545                550                555                560
Leu Asn Phe Asp Phe Ser Tyr Cys Glu Ser Asn Thr Cys Ser Tyr Gly 
                 565                570                575
Leu Met Asn Asn Phe Gln Val Met Ser Met Val Ser Gly Phe Ala Pro 
             580                585                590
Leu Ile Ser Ala Gly Ile Phe Ser Ala Thr Leu Ser Ser Ala Leu Ala 
         595                600                605
Ser Leu Val Ser Ala Pro Lys Ile Phe Gln Ala Leu Cys Lys Asp Asn 
     610                615                620
Ile Tyr Pro Ala Phe Gln Met Phe Ala Lys Gly Tyr Gly Lys Asn Asn 
 625                630                635                640
Glu Pro Leu Arg Gly Tyr Ile Leu Thr Phe Leu Ile Ala Leu Gly Phe 
                 645                650                655
Ile Leu Ile Ala Glu Leu Asn Val Ile Ala Pro Ile Ile Ser Asn Phe 
             660                665                670
Phe Leu Ala Ser Tyr Ala Leu Ile Asn Phe Ser Val Phe His Ala Ser 
         675                680                685
Leu Ala Lys Ser Pro Gly Trp Arg Pro Ala Phe Lys Tyr Tyr Asn Met 
     690                695                700
Trp Ile Ser Leu Thr Gly Ala Ile Leu Cys Cys Ile Val Met Phe Val 
 705                710                715                720
Ile Asn Trp Trp Ala Ala Leu Leu Thr Tyr Val Ile Val Leu Gly Leu 
                 725                730                735
Tyr Ile Tyr Val Thr Tyr Lys Lys Pro Asp Val Asn Trp Gly Ser Ser 
             740                745                750
Thr Gln Ala Leu Thr Tyr Leu Ser Ala Leu Gln His Ser Ile Arg Leu 
         755                760                765
Ser Gly Val Glu Asp His Val Lys Asn Phe Arg Pro Gln Cys Leu Val 
     770                775                780
Met Thr Gly Ser Pro Asn Ser Arg Pro Ala Leu Leu His Leu Val His 
 785                790                795                800
Asp Phe Thr Lys Asn Val Gly Leu Met Ile Cys Gly His Val His Met 
                 805                810                815
Gly Pro Arg Arg Gln Ala Met Lys Glu Met Ser Ile Asp Gln Ala Lys 
             820                825                830
Tyr Gln Arg Trp Leu Ile Lys Asn Lys Met Lys Ala Phe Tyr Ala Pro 
         835                840                845
Val His Ala Asp Asp Leu Arg Glu Gly Ala Gln Tyr Leu Met Gln Ala 
     850                855                860
Ala Gly Leu Gly Arg Met Lys Pro Asn Thr Leu Val Leu Gly Phe Lys 
 865                870                875                880
Lys Asp Trp Leu Gln Ala Asp Met Arg Asp Val Asp Met Tyr Ile Asn 
                 885                890                895
Leu Phe His Asp Ala Phe Asp Ile Gln Tyr Gly Val Val Val Ile Arg 
             900                905                910
Leu Lys Glu Gly Leu Asp Ile Ser His Leu Gln Gly Gln Glu Glu Leu 
         915                920                925
Leu Ser Ser Gln Glu Lys Ser Pro Gly Thr Lys Asp Val Val Val Asn 
     930                935                940
Val Asp Tyr Ser Lys Lys Ser Asp Gln Asp Ala Phe Lys Ala Ser Gly 
 945                950                955                960
Glu Lys Pro Ile Thr Gln Lys Asp Glu Glu Glu Asp Gly Lys Thr Ser 
                 965                970                975
Thr Gln Pro Leu Leu Lys Lys Glu Ser Lys Gly Pro Val Ala Pro Leu 
             980                985                990
Asn Val Ala Asp Gln Lys Leu Leu Glu Ala Ser Thr Gln Phe Gln Lys 
         995                1000                1005
Lys Gln Gly Lys Asn Thr Ile Asp Val Trp Trp Leu Phe Asp Asp Gly 
     1010                1015                1020
Gly Leu Thr Leu Leu Ile Pro Tyr Leu Leu Thr Thr Lys Lys Lys Trp 
 1025                1030                1035                1040
Lys Asp Cys Lys Ile Arg Val Phe Ile Gly Gly Lys Ile Asn Arg Ile 
                 1045                1050                1055
Asp His Asp Arg Arg Ala Met Ala Thr Leu Leu Ser Lys Phe Arg Ile 
             1060                1065                1070
Asp Phe Ser Asp Ile Met Val Leu Gly Asp Ile Asn Thr Lys Pro Lys 
         1075                1080                1085
Lys Glu Asn Ile Val Ala Phe Asp Asp Met Ile Glu Pro Tyr Arg Leu 
     1090                1095                1100
His Glu Asp Asp Lys Glu Gln Asp Ile Ala Asp Lys Met Lys Glu Asp 
 1105                1110                1115                1120
Glu Pro Trp Arg Ile Thr Asp Asn Glu Leu Glu Leu Tyr Lys Thr Lys 
                 1125                1130                1135
Thr Tyr Arg Gln Ile Arg Leu Asn Glu Leu Leu Lys Glu His Ser Ser 
             1140                1145                1150
Thr Ala Asn Ile Ile Val Met Ser Leu Pro Val Ala Arg Lys Gly Ala 
         1155                1160                1165
Val Ser Ser Ala Leu Tyr Met Ala Trp Leu Glu Ala Leu Ser Lys Asp 
     1170                1175                1180
Leu Pro Pro Ile Leu Leu Val Arg Gly Asn His Gln Ser Val Leu Thr 
 1185                1190                1195                1200
Phe Tyr Ser 
                 1205



<210> 884
<211> 316
<212> DNA
<213> Homo sapiens
<308> BE933612
<400> 884

gtgtatctt  ccttgtttt  ctcgaaact  gtgctagct  caagaagct  ttggtcagc  60
acatttaaa  gcacaatag  gccttggat  cttttttca  cagtggttg  gttgcagtc  120
tgccatcct  ttcctcaac  ttgtgtgta  ttgattttt  ataatggct  catttaata  180
ccagctgtc  aaatgaaaa  tttacaatc  gcttttcta  gttggtatg  gccagctta  240
cataccact  cattagtat  ccaaagaga  caagattca  cttttcctt  tggtgtttg  300
gaatataga  aagcta  316



<210> 885
<211> 1099
<212> PRT
<213> Homo sapiens
<308> NP_000329
<400> 885

Met Ser Leu Asn Asn Ser Ser Asn Val Phe Leu Asp Ser Val Pro Ser 
  1               5                  10                  15
Asn Thr Asn Arg Phe Gln Val Ser Val Ile Asn Glu Asn His Glu Ser 
             20                  25                  30
Ser Ala Ala Ala Asp Asp Asn Thr Asp Pro Pro His Tyr Glu Glu Thr 
         35                  40                  45
Ser Phe Gly Asp Glu Ala Gln Lys Arg Leu Arg Ile Ser Phe Arg Pro 
     50                  55                  60
Gly Asn Gln Glu Cys Tyr Asp Asn Phe Leu His Ser Gly Glu Thr Ala 
 65                  70                  75                  80
Lys Thr Asp Ala Ser Phe His Ala Tyr Asp Ser His Thr Asn Thr Tyr 
                 85                  90                  95
Tyr Leu Gln Thr Phe Gly His Asn Thr Met Asp Ala Val Pro Lys Ile 
             100                105                110
Glu Tyr Tyr Arg Asn Thr Gly Ser Ile Ser Gly Pro Lys Val Asn Arg 
         115                120                125
Pro Ser Leu Leu Glu Ile His Glu Gln Leu Ala Lys Asn Val Ala Val 
     130                135                140
Thr Pro Ser Ser Ala Asp Arg Val Ala Asn Gly Asp Gly Ile Pro Gly 
 145                150                155                160
Asp Glu Gln Ala Glu Asn Lys Glu Asp Asp Gln Ala Gly Val Val Lys 
                 165                170                175
Phe Gly Trp Val Lys Gly Val Leu Val Arg Cys Met Leu Asn Ile Trp 
             180                185                190
Gly Val Met Leu Phe Ile Arg Leu Ser Trp Ile Val Gly Glu Ala Gly 
         195                200                205
Ile Gly Leu Gly Val Ile Ile Ile Gly Leu Ser Thr Ile Val Thr Thr 
     210                215                220
Ile Thr Gly Met Ser Thr Ser Ala Ile Ala Thr Asn Gly Val Val Arg 
 225                230                235                240
Gly Gly Gly Ala Tyr Tyr Leu Ile Ser Arg Ser Leu Gly Pro Glu Phe 
                 245                250                255
Gly Gly Ser Ile Gly Leu Ile Phe Ala Phe Ala Asn Ala Val Ala Val 
             260                265                270
Ala Met Tyr Val Val Gly Phe Ala Glu Thr Val Val Asp Leu Leu Lys 
         275                280                285
Glu Ser Asp Ser Met Met Val Asp Pro Thr Asn Asp Ile Arg Ile Ile 
     290                295                300
Gly Ser Ile Thr Val Val Ile Leu Leu Gly Ile Ser Val Ala Gly Met 
 305                310                315                320
Glu Trp Glu Ala Lys Ala Gln Val Ile Leu Leu Val Ile Leu Leu Ile 
                 325                330                335
Ala Ile Ala Asn Phe Phe Ile Gly Thr Val Ile Pro Ser Asn Asn Glu 
             340                345                350
Lys Lys Ser Arg Gly Phe Phe Asn Tyr Gln Ala Ser Ile Phe Ala Glu 
         355                360                365
Asn Phe Gly Pro Arg Phe Thr Lys Gly Glu Gly Phe Phe Ser Val Phe 
     370                375                380
Ala Ile Phe Phe Pro Ala Ala Thr Gly Ile Leu Ala Gly Ala Asn Ile 
 385                390                395                400
Ser Gly Asp Leu Glu Asp Pro Gln Asp Ala Ile Pro Arg Gly Thr Met 
                 405                410                415
Leu Ala Ile Phe Ile Thr Thr Val Ala Tyr Leu Gly Val Ala Ile Cys 
             420                425                430
Val Gly Ala Cys Val Val Arg Asp Ala Thr Gly Asn Met Asn Asp Thr 
         435                440                445
Ile Ile Ser Gly Met Asn Cys Asn Gly Ser Ala Ala Cys Gly Leu Gly 
     450                455                460
Tyr Asp Phe Ser Arg Cys Arg His Glu Pro Cys Gln Tyr Gly Leu Met 
 465                470                475                480
Asn Asn Phe Gln Val Met Ser Met Val Ser Gly Phe Gly Pro Leu Ile 
                 485                490                495
Thr Ala Gly Ile Phe Ser Ala Thr Leu Ser Ser Ala Leu Ala Ser Leu 
             500                505                510
Val Ser Ala Pro Lys Val Phe Gln Ala Leu Cys Lys Asp Asn Ile Tyr 
         515                520                525
Lys Ala Leu Gln Phe Phe Ala Lys Gly Tyr Gly Lys Asn Asn Glu Pro 
     530                535                540
Leu Arg Gly Tyr Ile Leu Thr Phe Leu Ile Ala Met Ala Phe Ile Leu 
 545                550                555                560
Ile Ala Glu Leu Asn Thr Ile Ala Pro Ile Ile Ser Asn Phe Phe Leu 
                 565                570                575
Ala Ser Tyr Ala Leu Ile Asn Phe Ser Cys Phe His Ala Ser Tyr Ala 
             580                585                590
Lys Ser Pro Gly Trp Arg Pro Ala Tyr Gly Ile Tyr Asn Met Trp Val 
         595                600                605
Ser Leu Phe Gly Ala Val Leu Cys Cys Ala Val Met Phe Val Ile Asn 
     610                615                620
Trp Trp Ala Ala Val Ile Thr Tyr Val Ile Glu Phe Phe Leu Tyr Val 
 625                630                635                640
Tyr Val Thr Cys Lys Lys Pro Asp Val Asn Trp Gly Ser Ser Thr Gln 
                 645                650                655
Ala Leu Ser Tyr Val Ser Ala Leu Asp Asn Ala Leu Glu Leu Thr Thr 
             660                665                670
Val Glu Asp His Val Lys Asn Phe Arg Pro Gln Cys Ile Val Leu Thr 
         675                680                685
Gly Gly Pro Met Thr Arg Pro Ala Leu Leu Asp Ile Thr His Ala Phe 
     690                695                700
Thr Lys Asn Ser Gly Leu Cys Ile Cys Cys Glu Val Phe Val Gly Pro 
 705                710                715                720
Arg Lys Leu Cys Val Lys Glu Met Asn Ser Gly Met Ala Lys Lys Gln 
                 725                730                735
Ala Trp Leu Ile Lys Asn Lys Ile Lys Ala Phe Tyr Ala Ala Val Ala 
             740                745                750
Ala Asp Cys Phe Arg Asp Gly Val Arg Ser Leu Leu Gln Ala Ser Gly 
         755                760                765
Leu Gly Arg Met Lys Pro Asn Thr Leu Val Ile Gly Tyr Lys Lys Asn 
     770                775                780
Trp Arg Lys Ala Pro Leu Thr Glu Ile Glu Asn Tyr Val Gly Ile Ile 
 785                790                795                800
His Asp Ala Phe Asp Phe Glu Ile Gly Val Val Ile Val Arg Ile Ser 
                 805                810                815
Gln Gly Phe Asp Ile Ser Gln Val Leu Gln Val Gln Glu Glu Leu Glu 
             820                825                830
Arg Leu Glu Gln Glu Arg Leu Ala Leu Glu Ala Thr Ile Lys Asp Asn 
         835                840                845
Glu Cys Glu Glu Glu Ser Gly Gly Ile Arg Gly Leu Phe Lys Lys Ala 
     850                855                860
Gly Lys Leu Asn Ile Thr Lys Thr Thr Pro Lys Lys Asp Gly Ser Ile 
 865                870                875                880
Asn Thr Ser Gln Ser Met His Val Gly Glu Phe Asn Gln Lys Leu Val 
                 885                890                895
Glu Ala Ser Thr Gln Phe Lys Lys Lys Gln Glu Lys Gly Thr Ile Asp 
             900                905                910
Val Trp Trp Leu Phe Asp Asp Gly Gly Leu Thr Leu Leu Ile Pro Tyr 
         915                920                925
Ile Leu Thr Leu Arg Lys Lys Trp Lys Asp Cys Lys Leu Arg Ile Tyr 
     930                935                940
Val Gly Gly Lys Ile Asn Arg Ile Glu Glu Glu Lys Ile Ala Met Ala 
 945                950                955                960
Ser Leu Leu Ser Lys Phe Arg Ile Lys Phe Ala Asp Ile His Ile Ile 
                 965                970                975
Gly Asp Ile Asn Ile Arg Pro Asn Lys Glu Ser Trp Lys Val Phe Glu 
             980                985                990
Glu Met Ile Glu Pro Tyr Arg Leu His Glu Ser Cys Lys Asp Leu Thr 
         995                1000                1005
Thr Ala Glu Lys Leu Lys Arg Glu Thr Pro Trp Lys Ile Thr Asp Ala 
     1010                1015                1020
Glu Leu Glu Ala Val Lys Glu Lys Ser Tyr Arg Gln Val Arg Leu Asn 
 1025                1030                1035                1040
Glu Leu Leu Gln Glu His Ser Arg Ala Ala Asn Leu Ile Val Leu Ser 
                 1045                1050                1055
Leu Pro Val Ala Arg Lys Gly Ser Ile Ser Asp Leu Leu Tyr Met Ala 
             1060                1065                1070
Trp Leu Glu Ile Leu Thr Lys Asn Leu Pro Pro Val Leu Leu Val Arg 
         1075                1080                1085
Gly Asn His Lys Asn Val Leu Thr Phe Tyr Ser 
     1090                1095



<210> 886
<211> 6402
<212> DNA
<213> Rattus norvegicus
<308> AF051561
<400> 886

tgtgaggca  cggcgctgc  actctctct  ccccggctc  ttagtggga  cgccggcca  60
ggacccgag  cgcgctgta  gcagcgtcc  cccgcccgc  ccgcaggtc  ccgagcgtc  120
ggcggcgat  gagcccggg  ccgcggcgc  ctcgtctgg  gccccgcgg  ccgcccggg  180
tggggacgc  ccgctgact  ccgccgggg  ggacctgcc  ggcacggcc  tactctccg  240
tcgagagga  gctaccgct  ggagccagg  cggcggcgg  gtgcgcgga  agggaaccc  300
ggccgctgg  gatgggctg  gcaaacctc  ggggcccac  cccagccag  gccgcttcc  360
ggtggaccc  gtttccgag  acgccgggc  ggccgcggc  gctgcagct  cagcggcgg  420
tgcggcggc  gccggggca  cgggcaagg  gacccccgc  gctgggaaa  ccggcactg  480
gagcggcgt  gccaagggc  gcgaggaag  caagggccg  ttccgcgtg  acttcgtgg  540
cccggctgc  tcctcgtcg  cggacgaca  cctgtcgga  gcggcggga  tcggtggcg  600
cgggcccaa  gtgagctcc  agaacggcg  ggacacggt  ctgagcgag  gcagcagcc  660
gcactcggg  ggtggcagt  gacaccacc  gcagtacta  tatgacacc  acaccaaca  720
ttactacct  cgcaccttc  gccacaaca  catggacgc  gtgcccagg  tcgaccact  780
ccggcacac  gccgcgcag  tgggcgaga  gctgctccg  cccagcctg  gagagttcc  840
cgatgagct  gaaaaggaa  cttttgagg  tggttttgc  aatggagaa  aaagtactc  900
aaccagaga  gctgtggtc  catacactg  cgaaagtaa  ggagttgta  agtttggct  960
gatcaaggg  gttttagta  gatgtatgt  gaatatttg  ggtgtgatg  tctttattc  1020
attgtcatg  attgtgggt  aggctggaa  aggtctctc  gttcttgta  tagcaatgg  1080
cactgttgt  acaaccatc  caggattgt  tacttcagc  atagctacc  atggattcg  1140
gagaggagg  ggagcatac  atttaatct  tagaagtct  gggccagaa  ttggcggtg  1200
gattggctt  atcttcgct  ttcccaatg  agtggcagt  gctatgtat  ttgttggat  1260
cgcagagac  gtagtggag  tgcttaagg  acattccat  cttatgata  atgaaatca  1320
tgacatccg  attattgga  ccattacag  ggtggttct  ctgggcatc  cagtggccg  1380
aatggagtg  gaagcaaag  ctcagatcg  ccttctggt  attcttctt  tggccatcg  1440
tgacttcgt  ataggaaca  ttatctcac  ggacagcaa  aagcccaag  gtttctttg  1500
ctataaatc  gaaatattt  gtgagaact  tggaccgga  tttcgagaa  aagagactt  1560
cttttctgt  ttcgccatc  tttttcctg  tgcaactgg  attctagct  gggcgaaca  1620
ctcgggtga  cttgcagat  ctcagtcag  catacccaa  ggaacgctc  tagccattt  1680
gattacgac  gtggtttac  taggaatcg  agtgtctgt  ggttcttgt  ttgtccggg  1740
tgccactgg  aacgttaat  acaccatta  aacagagct  actaactgt  cttctgcag  1800
ctgcaaatt  aactttgac  tttcctact  tgaaagcaa  acctgttct  atgggctaa  1860
gaacaactt  caggtgatg  gcatggtgt  aggatttgc  cccctgatc  ctgcgggta  1920
cttttcagc  acactctca  cagcactgg  atctcttgt  agtgctccc  aaatatttc  1980
ggctctatg  aaggacaat  tctacccag  tttccagat  tttgcgaaa  gttatggaa  2040
aaataatga  cctcttcgt  gttacatct  aacattctt  attgcactt  gattcatct  2100
aattgctga  ttgaatgtc  ttgctccaa  tatctctaa  ttctttctc  catcatacg  2160
cttaatcaa  ttttctgta  tccatgcgt  acttgcaaa  tctccaggg  ggcgtcctg  2220
gttcaagta  tacaacatg  ggatctccc  tactggagc  attctctgc  gcatagtga  2280
gttcgtcat  aactggtgg  ctgcactgc  cacatatgt  atagttctt  gactgtaca  2340
ttatgtcac  tacaaaaag  cagatgtga  ctggggatc  tccacacaa  cgctgactt  2400
cctcagcgc  ctgcagcat  caatccgtc  ttccggggt  gaggaccat  tgaaaaact  2460
caggccaca  tgtcttgta  tgacaggtt  tccaaactc  cggcctgct  tactgcatc  2520
tgttcatga  ttcacgaaa  atgttggtt  aatgatctg  ggccatgtg  atatgggtc  2580
ccgaagaca  gctatgaaa  agatgtcca  tgatcaagc  aaatatcag  gatggctca  2640
taaaaacaa  atgaaggct  tctacgctc  ggttcacgc  gatgacttg  gggaaggtg  2700
acagtacct  atgcaggct  ctggacttg  tcgtatgaa  ccaaacaca  ttgtcctcg  2760
atttaagaa  gattggtta  aagcagata  gagggatgt  gatatgtat  taaacttat  2820
tcatgatgc  tttgacata  agtatggag  tgtggtcat  cgcctaaag  aaggactgg  2880
tatatcaca  ctccaagga  aagaagaat  attgtcatc  caagaaaag  cacctggta  2940
caaggatgt  gtagtaaat  tggactaca  taagaagtc  gatcaagat  ctttcaaag  3000
atctggtga  aaacctatt  cacagaaag  tgaggaaga  gatggcaag  cttcaactc  3060
gccactgtt  aaaaaagaa  ccaagggcc  cgtggcacc  ttaaatgta  ctgaccaaa  3120
gcttcttga  gctagcaca  agtttcaga  aaaacaagg  aagaatact  tagatgtct  3180
gtggctttt  gatgatgga  gtttgacct  gttgatacc  tatcttctg  caaccaaga  3240
aaagtggaa  gattgtaag  tccgagtat  cattggtgg  aagataaac  gaatagacc  3300
tgaccggag  gcgatggct  ctttactca  taaattccg  atagacttc  ccgatatca  3360
ggtcctagg  gacatcaac  ccaaaccaa  aaaggaaaa  atcgtcgct  ttgatgaca  3420
gattgagcc  tacagactt  acgaggatg  taaagagca  gatattgca  acaaaatga  3480
agaggatga  ccctggcgc  tcacagaca  cgagctgga  ctctacaag  ccaagacat  3540
tcggcagat  aggttaaat  aattattaa  ggagcattc  agcacagct  atattattg  3600
catgagtct  ccagttgcc  ggaagggtg  tgtgtccag  gcgctgtac  tggcttggt  3660
agaagctct  tctaaggac  tgccaccaa  cctgctggt  cgtgggaat  atcagagcg  3720
ccttacctt  tactcttaa  tgtcctgcc  catggactc  ctctaagaa  ggtacttca  3780
tgcctagtc  gagtgactg  atcgtcagc  acaccgcag  atcacagtg  cgaactggg  3840
ctttgtttc  ctacttcat  ctttgaaag  acatggaca  gttgctcca  tgatagatc  3900
gtggagact  cggttttag  ctactccag  tctcagtct  atgactgct  attcttcct  3960
gttggactg  agttcttga  agtaaagtt  tcctttgct  cttgacagc  ataagagtg  4020
gttattttt  attgctgaa  ggagtacat  agcctttag  cttgaggtg  cttctgaaa  4080
taaccaaat  tcatccata  atctatcgt  ttttgtaca  ttatagaat  ttaaactct  4140
ccttcagac  ttattttta  ttctaatct  tgtcatcct  agtggacac  gcttgtctc  4200
tcccattga  cagttagtg  tgagagctg  gtgtttcgt  ttacttttg  aaaagcgtt  4260
gttggatac  gaagagggt  ggacaagct  ataaaatat  tggagaaag  atccaaaaa  4320
ggagcccaa  gttaggttt  tatgaatag  tacttagag  tagggaaga  aggcccgaa  4380
accgtttct  tctctcaat  agagttatc  attatttct  ttaaatcat  gagatgact  4440
acgatctac  cagtacttc  tttataaca  aaaaaaaaa  aatcacatt  ttttaaagc  4500
aaaccttga  gtcatttgt  ttgttttta  aagatctct  ttaatttag  atttcctct  4560
aaatgggag  gacttttaa  acatgctaa  tggtatttt  cgaggaaat  tagacaaag  4620
attgccatt  actagagca  ttcaataaa  actatgggg  tttcactat  ctatcgcat  4680
ctttattta  aaagaaaga  gacaatgtt  tcaatggtt  aatggacca  tgttttctt  4740
gtgaaatgg  tttaggctt  atttattca  gtatcaaga  catttagtc  taatacact  4800
aggtttgaa  agattattc  gaacattga  atttaatcc  ttcttaata  tttaaaact  4860
gcgttaaag  aaactgcca  tttgtgcat  tgaccttgt  gtctgcaag  gcacttgac  4920
gtgagcgtg  acacctgcg  tgtcctgaa  gctttatac  cagtcgtta  tgtgaagtg  4980
ctaagttca  ggaaggatc  tctaaacat  tcaagggat  catgtccac  tgtctgtct  5040
tgtgtatgt  ttgcataca  aggtgcata  gtgtatatg  aatgaaatt  atgttgcca  5100
tgtttcaga  tttaaagcg  tcatgattt  gtaggttac  gattttgtt  ttgttgttg  5160
tttagtttt  tcttttctt  tttaagtaa  cattcaagt  agatcaaga  attacagat  5220
tcatggagg  caaagacaa  tgaaagaac  tcgtgtagc  ttgtacagt  atccagtta  5280
gtaaagtag  tgatctgta  gtttcagtg  agaacatag  gcagacttt  atcatctta  5340
gggaaatgt  agaaaagca  ttcagtagt  tagtacttg  gctccatga  aacagactg  5400
gttaatacc  gctggatat  ttctcgttt  cactcagaa  attaaagaa  acaaggtta  5460
gtgattttt  ccaagttct  cttacatta  aatataata  tgttccatt  attgtaaat  5520
ttgcagagt  tagggcagt  tagaagaat  atattagca  accatatca  gtgtggatc  5580
tctgaatgg  tactagggc  tgggctgaa  gctgctatc  tgaaatgta  acagctaga  5640
ttgcctttt  tttttaaag  ttttccctc  ttcaggaaa  ttcattgtg  tctgtacta  5700
agaaactaa  tgtcataca  catacgtgt  tgttcaaag  acataaaat  gatctcaac  5760
cacctaaca  ggagggtgg  gacactgtg  agtgatgcc  gcagcagct  tctactctt  5820
aaaaccgcc  tccgtcgtc  gctaacacg  gctgccagg  cagacgttc  caaggttgc  5880
gtagtactc  aaaacgaaa  ttctcaatg  ttaattctt  gacatctag  tagtattag  5940
gctgttttc  ttttacgct  tttggatta  ttggatgcc  aattatgtt  tagtcctaa  6000
cattgataa  aacttaaaa  tacgcagtg  catttgagc  cattcttgg  ataagttaa  6060
aacttgagt  cgttcaaag  gaacgtcgt  gatgattaa  ggttcacta  atcagatat  6120
catttgtct  atcttttcc  tcctgcttt  ttttccttc  ctcttctca  atggctctc  6180
tgacgtgtg  gtggtttgt  ttgttttgt  tttttaaga  tatggaaat  atttaatga  6240
ttgagctcc  gtgatgatc  gctaagttt  aaaatgtaa  attttgata  tactgtact  6300
tacctgtcc  aaatgcttt  gtaatgttt  aaccccgag  attgcagtt  ctgctccgt  6360
cagaggtta  tgcaataaa  gaagtggaa  cattaaaac  tt  6402



<210> 887
<211> 1203
<212> PRT
<213> Rattus norvegicus
<308> AAC27557
<400> 887

Met Glu Pro Gly Pro Ala Ala Pro Ser Ser Gly Ala Pro Arg Pro Ala 
  1               5                  10                  15
Arg Asp Gly Asp Ala Pro Leu Thr Ala Ala Gly Val Asp Leu Pro Gly 
             20                  25                  30
Thr Ala Val Leu Ser Gly Arg Glu Asp Ala Thr Ala Gly Ser Gln Ala 
         35                  40                  45
Gly Gly Gly Val Arg Gly Glu Gly Thr Pro Ala Ala Gly Asp Gly Leu 
     50                  55                  60
Gly Lys Pro Leu Gly Pro Thr Pro Ser Gln Ser Arg Phe Gln Val Asp 
 65                  70                  75                  80
Pro Val Ser Glu Asn Ala Gly Arg Ala Ala Ala Ala Ala Ala Ala Ala 
                 85                  90                  95
Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly Lys Glu Thr Pro Ala Ala 
             100                105                110
Gly Lys Ala Gly Thr Glu Ser Gly Val Ala Lys Gly Ser Glu Glu Ala 
         115                120                125
Lys Gly Arg Phe Arg Val Asn Phe Val Asp Pro Ala Ala Ser Ser Ser 
     130                135                140
Ala Asp Asp Ser Leu Ser Asp Ala Ala Gly Val Gly Gly Asp Gly Pro 
 145                150                155                160
Asn Val Ser Ser Gln Asn Gly Gly Asp Thr Val Leu Ser Glu Gly Ser 
                 165                170                175
Ser Leu His Ser Gly Gly Gly Ser Gly His His Gln Gln Tyr Tyr Tyr 
             180                185                190
Asp Thr His Thr Asn Thr Tyr Tyr Leu Arg Thr Phe Gly His Asn Thr 
         195                200                205
Met Asp Ala Val Pro Arg Ile Asp His Tyr Arg His Thr Ala Ala Gln 
     210                215                220
Leu Gly Glu Lys Leu Leu Arg Pro Ser Leu Gly Glu Phe His Asp Glu 
 225                230                235                240
Leu Glu Lys Glu Pro Phe Glu Asp Gly Phe Ala Asn Gly Glu Glu Ser 
                 245                250                255
Thr Pro Thr Arg Asp Ala Val Val Thr Tyr Thr Ala Glu Ser Lys Gly 
             260                265                270
Val Val Lys Phe Gly Trp Ile Lys Gly Val Leu Val Arg Cys Met Leu 
         275                280                285
Asn Ile Trp Gly Val Met Leu Phe Ile Arg Leu Ser Trp Ile Val Gly 
     290                295                300
Gln Ala Gly Ile Gly Leu Ser Val Leu Val Ile Ala Met Ala Thr Val 
 305                310                315                320
Val Thr Thr Ile Thr Gly Leu Ser Thr Ser Ala Ile Ala Thr Asn Gly 
                 325                330                335
Phe Val Arg Gly Gly Gly Ala Tyr Tyr Leu Ile Ser Arg Ser Leu Gly 
             340                345                350
Pro Glu Phe Gly Gly Ala Ile Gly Leu Ile Phe Ala Phe Pro Asn Ala 
         355                360                365
Val Ala Val Ala Met Tyr Val Val Gly Phe Ala Glu Thr Val Val Glu 
     370                375                380
Leu Leu Lys Glu His Ser Ile Leu Met Ile Asp Glu Ile Asn Asp Ile 
 385                390                395                400
Arg Ile Ile Gly Ala Ile Thr Val Val Val Leu Leu Gly Ile Ser Val 
                 405                410                415
Ala Gly Met Glu Trp Glu Ala Lys Ala Gln Ile Val Leu Leu Val Ile 
             420                425                430
Leu Leu Leu Ala Ile Ala Asp Phe Val Ile Gly Thr Phe Ile Ser Leu 
         435                440                445
Asp Ser Lys Lys Pro Lys Gly Phe Phe Gly Tyr Lys Ser Glu Ile Phe 
     450                455                460
Ser Glu Asn Phe Gly Pro Asp Phe Arg Glu Glu Glu Thr Phe Phe Ser 
 465                470                475                480
Val Phe Ala Ile Phe Phe Pro Ala Ala Thr Gly Ile Leu Ala Gly Ala 
                 485                490                495
Asn Ile Ser Gly Asp Leu Ala Asp Pro Gln Ser Ala Ile Pro Lys Gly 
             500                505                510
Thr Leu Leu Ala Ile Leu Ile Thr Thr Val Val Tyr Ile Gly Ile Ala 
         515                520                525
Val Ser Val Gly Ser Cys Val Val Arg Asp Ala Thr Gly Asn Val Asn 
     530                535                540
Asp Thr Ile Thr Thr Glu Leu Thr Asn Cys Thr Ser Ala Ala Cys Lys 
 545                550                555                560
Leu Asn Phe Asp Phe Ser Tyr Cys Glu Ser Asn Thr Cys Ser Tyr Gly 
                 565                570                575
Leu Met Asn Asn Phe Gln Val Met Ser Met Val Ser Gly Phe Ala Pro 
             580                585                590
Leu Ile Ser Ala Gly Ile Phe Ser Ala Thr Leu Ser Ser Ala Leu Ala 
         595                600                605
Ser Leu Val Ser Ala Pro Lys Ile Phe Gln Ala Leu Cys Lys Asp Asn 
     610                615                620
Ile Tyr Pro Ala Phe Gln Met Phe Ala Lys Gly Tyr Gly Lys Asn Asn 
 625                630                635                640
Glu Pro Leu Arg Gly Tyr Ile Leu Thr Phe Leu Ile Ala Leu Gly Phe 
                 645                650                655
Ile Leu Ile Ala Glu Leu Asn Val Ile Ala Pro Ile Ile Ser Asn Phe 
             660                665                670
Phe Leu Ala Ser Tyr Ala Leu Ile Asn Phe Ser Val Phe His Ala Ser 
         675                680                685
Leu Ala Lys Ser Pro Gly Trp Arg Pro Ala Phe Lys Tyr Tyr Asn Met 
     690                695                700
Trp Ile Ser Leu Thr Gly Ala Ile Leu Cys Cys Ile Val Met Phe Val 
 705                710                715                720
Ile Asn Trp Trp Ala Ala Leu Leu Thr Tyr Val Ile Val Leu Gly Leu 
                 725                730                735
Tyr Ile Tyr Val Thr Tyr Lys Lys Pro Asp Val Asn Trp Gly Ser Ser 
             740                745                750
Thr Gln Ala Leu Thr Tyr Leu Ser Ala Leu Gln His Ser Ile Arg Leu 
         755                760                765
Ser Gly Val Glu Asp His Val Lys Asn Phe Arg Pro Gln Cys Leu Val 
     770                775                780
Met Thr Gly Ser Pro Asn Ser Arg Pro Ala Leu Leu His Leu Val His 
 785                790                795                800
Asp Phe Thr Lys Asn Val Gly Leu Met Ile Cys Gly His Val His Met 
                 805                810                815
Gly Pro Arg Arg Gln Ala Met Lys Glu Met Ser Ile Asp Gln Ala Lys 
             820                825                830
Tyr Gln Arg Trp Leu Ile Lys Asn Lys Met Lys Ala Phe Tyr Ala Pro 
         835                840                845
Val His Ala Asp Asp Leu Arg Glu Gly Ala Gln Tyr Leu Met Gln Ala 
     850                855                860
Ala Gly Leu Gly Arg Met Lys Pro Asn Thr Leu Val Leu Gly Phe Lys 
 865                870                875                880
Lys Asp Trp Leu Gln Ala Asp Met Arg Asp Val Asp Met Tyr Ile Asn 
                 885                890                895
Leu Phe His Asp Ala Phe Asp Ile Gln Tyr Gly Val Val Val Ile Arg 
             900                905                910
Leu Lys Glu Gly Leu Asp Ile Ser His Leu Gln Gly Gln Glu Glu Leu 
         915                920                925
Leu Ser Ser Gln Glu Lys Ser Pro Gly Thr Lys Asp Val Val Val Asn 
     930                935                940
Val Asp Tyr Ser Lys Lys Ser Asp Gln Asp Ala Phe Lys Ala Ser Gly 
 945                950                955                960
Glu Lys Pro Ile Thr Gln Lys Asp Glu Glu Glu Asp Gly Lys Thr Ser 
                 965                970                975
Thr Gln Pro Leu Leu Lys Lys Glu Ser Lys Gly Pro Val Ala Pro Leu 
             980                985                990
Asn Val Ala Asp Gln Lys Leu Leu Glu Ala Ser Thr Gln Phe Gln Lys 
         995                1000                1005
Lys Gln Gly Lys Asn Thr Ile Asp Val Trp Trp Leu Phe Asp Asp Gly 
     1010                1015                1020
Gly Leu Thr Leu Leu Ile Pro Tyr Leu Leu Thr Thr Lys Lys Lys Trp 
 1025                1030                1035                1040
Lys Asp Cys Lys Ile Arg Val Phe Ile Gly Gly Lys Ile Asn Arg Ile 
                 1045                1050                1055
Asp His Asp Arg Arg Ala Met Ala Thr Leu Leu Ser Lys Phe Arg Ile 
             1060                1065                1070
Asp Phe Ser Asp Ile Met Val Leu Gly Asp Ile Asn Thr Lys Pro Lys 
         1075                1080                1085
Lys Glu Asn Ile Val Ala Phe Asp Asp Met Ile Glu Pro Tyr Arg Leu 
     1090                1095                1100
His Glu Asp Asp Lys Glu Gln Asp Ile Ala Asp Lys Met Lys Glu Asp 
 1105                1110                1115                1120
Glu Pro Trp Arg Ile Thr Asp Asn Glu Leu Glu Leu Tyr Lys Thr Lys 
                 1125                1130                1135
Thr Tyr Arg Gln Ile Arg Leu Asn Glu Leu Leu Lys Glu His Ser Ser 
             1140                1145                1150
Thr Ala Asn Ile Ile Val Met Ser Leu Pro Val Ala Arg Lys Gly Ala 
         1155                1160                1165
Val Ser Ser Ala Leu Tyr Met Ala Trp Leu Glu Ala Leu Ser Lys Asp 
     1170                1175                1180
Leu Pro Pro Ile Leu Leu Val Arg Gly Asn His Gln Ser Val Leu Thr 
 1185                1190                1195                1200
Phe Tyr Ser 
                 1205



<210> 888
<211> 316
<212> DNA
<213> Homo sapiens
<308> BE933612
<400> 888

gtgtatctt  ccttgtttt  ctcgaaact  gtgctagct  caagaagct  ttggtcagc  60
acatttaaa  gcacaatag  gccttggat  cttttttca  cagtggttg  gttgcagtc  120
tgccatcct  ttcctcaac  ttgtgtgta  ttgattttt  ataatggct  catttaata  180
ccagctgtc  aaatgaaaa  tttacaatc  gcttttcta  gttggtatg  gccagctta  240
cataccact  cattagtat  ccaaagaga  caagattca  cttttcctt  tggtgtttg  300
gaatataga  aagcta  316



<210> 889
<211> 1099
<212> PRT
<213> Homo sapiens
<308> NP_000329
<400> 889

Met Ser Leu Asn Asn Ser Ser Asn Val Phe Leu Asp Ser Val Pro Ser 
  1               5                  10                  15
Asn Thr Asn Arg Phe Gln Val Ser Val Ile Asn Glu Asn His Glu Ser 
             20                  25                  30
Ser Ala Ala Ala Asp Asp Asn Thr Asp Pro Pro His Tyr Glu Glu Thr 
         35                  40                  45
Ser Phe Gly Asp Glu Ala Gln Lys Arg Leu Arg Ile Ser Phe Arg Pro 
     50                  55                  60
Gly Asn Gln Glu Cys Tyr Asp Asn Phe Leu His Ser Gly Glu Thr Ala 
 65                  70                  75                  80
Lys Thr Asp Ala Ser Phe His Ala Tyr Asp Ser His Thr Asn Thr Tyr 
                 85                  90                  95
Tyr Leu Gln Thr Phe Gly His Asn Thr Met Asp Ala Val Pro Lys Ile 
             100                105                110
Glu Tyr Tyr Arg Asn Thr Gly Ser Ile Ser Gly Pro Lys Val Asn Arg 
         115                120                125
Pro Ser Leu Leu Glu Ile His Glu Gln Leu Ala Lys Asn Val Ala Val 
     130                135                140
Thr Pro Ser Ser Ala Asp Arg Val Ala Asn Gly Asp Gly Ile Pro Gly 
 145                150                155                160
Asp Glu Gln Ala Glu Asn Lys Glu Asp Asp Gln Ala Gly Val Val Lys 
                 165                170                175
Phe Gly Trp Val Lys Gly Val Leu Val Arg Cys Met Leu Asn Ile Trp 
             180                185                190
Gly Val Met Leu Phe Ile Arg Leu Ser Trp Ile Val Gly Glu Ala Gly 
         195                200                205
Ile Gly Leu Gly Val Ile Ile Ile Gly Leu Ser Thr Ile Val Thr Thr 
     210                215                220
Ile Thr Gly Met Ser Thr Ser Ala Ile Ala Thr Asn Gly Val Val Arg 
 225                230                235                240
Gly Gly Gly Ala Tyr Tyr Leu Ile Ser Arg Ser Leu Gly Pro Glu Phe 
                 245                250                255
Gly Gly Ser Ile Gly Leu Ile Phe Ala Phe Ala Asn Ala Val Ala Val 
             260                265                270
Ala Met Tyr Val Val Gly Phe Ala Glu Thr Val Val Asp Leu Leu Lys 
         275                280                285
Glu Ser Asp Ser Met Met Val Asp Pro Thr Asn Asp Ile Arg Ile Ile 
     290                295                300
Gly Ser Ile Thr Val Val Ile Leu Leu Gly Ile Ser Val Ala Gly Met 
 305                310                315                320
Glu Trp Glu Ala Lys Ala Gln Val Ile Leu Leu Val Ile Leu Leu Ile 
                 325                330                335
Ala Ile Ala Asn Phe Phe Ile Gly Thr Val Ile Pro Ser Asn Asn Glu 
             340                345                350
Lys Lys Ser Arg Gly Phe Phe Asn Tyr Gln Ala Ser Ile Phe Ala Glu 
         355                360                365
Asn Phe Gly Pro Arg Phe Thr Lys Gly Glu Gly Phe Phe Ser Val Phe 
     370                375                380
Ala Ile Phe Phe Pro Ala Ala Thr Gly Ile Leu Ala Gly Ala Asn Ile 
 385                390                395                400
Ser Gly Asp Leu Glu Asp Pro Gln Asp Ala Ile Pro Arg Gly Thr Met 
                 405                410                415
Leu Ala Ile Phe Ile Thr Thr Val Ala Tyr Leu Gly Val Ala Ile Cys 
             420                425                430
Val Gly Ala Cys Val Val Arg Asp Ala Thr Gly Asn Met Asn Asp Thr 
         435                440                445
Ile Ile Ser Gly Met Asn Cys Asn Gly Ser Ala Ala Cys Gly Leu Gly 
     450                455                460
Tyr Asp Phe Ser Arg Cys Arg His Glu Pro Cys Gln Tyr Gly Leu Met 
 465                470                475                480
Asn Asn Phe Gln Val Met Ser Met Val Ser Gly Phe Gly Pro Leu Ile 
                 485                490                495
Thr Ala Gly Ile Phe Ser Ala Thr Leu Ser Ser Ala Leu Ala Ser Leu 
             500                505                510
Val Ser Ala Pro Lys Val Phe Gln Ala Leu Cys Lys Asp Asn Ile Tyr 
         515                520                525
Lys Ala Leu Gln Phe Phe Ala Lys Gly Tyr Gly Lys Asn Asn Glu Pro 
     530                535                540
Leu Arg Gly Tyr Ile Leu Thr Phe Leu Ile Ala Met Ala Phe Ile Leu 
 545                550                555                560
Ile Ala Glu Leu Asn Thr Ile Ala Pro Ile Ile Ser Asn Phe Phe Leu 
                 565                570                575
Ala Ser Tyr Ala Leu Ile Asn Phe Ser Cys Phe His Ala Ser Tyr Ala 
             580                585                590
Lys Ser Pro Gly Trp Arg Pro Ala Tyr Gly Ile Tyr Asn Met Trp Val 
         595                600                605
Ser Leu Phe Gly Ala Val Leu Cys Cys Ala Val Met Phe Val Ile Asn 
     610                615                620
Trp Trp Ala Ala Val Ile Thr Tyr Val Ile Glu Phe Phe Leu Tyr Val 
 625                630                635                640
Tyr Val Thr Cys Lys Lys Pro Asp Val Asn Trp Gly Ser Ser Thr Gln 
                 645                650                655
Ala Leu Ser Tyr Val Ser Ala Leu Asp Asn Ala Leu Glu Leu Thr Thr 
             660                665                670
Val Glu Asp His Val Lys Asn Phe Arg Pro Gln Cys Ile Val Leu Thr 
         675                680                685
Gly Gly Pro Met Thr Arg Pro Ala Leu Leu Asp Ile Thr His Ala Phe 
     690                695                700
Thr Lys Asn Ser Gly Leu Cys Ile Cys Cys Glu Val Phe Val Gly Pro 
 705                710                715                720
Arg Lys Leu Cys Val Lys Glu Met Asn Ser Gly Met Ala Lys Lys Gln 
                 725                730                735
Ala Trp Leu Ile Lys Asn Lys Ile Lys Ala Phe Tyr Ala Ala Val Ala 
             740                745                750
Ala Asp Cys Phe Arg Asp Gly Val Arg Ser Leu Leu Gln Ala Ser Gly 
         755                760                765
Leu Gly Arg Met Lys Pro Asn Thr Leu Val Ile Gly Tyr Lys Lys Asn 
     770                775                780
Trp Arg Lys Ala Pro Leu Thr Glu Ile Glu Asn Tyr Val Gly Ile Ile 
 785                790                795                800
His Asp Ala Phe Asp Phe Glu Ile Gly Val Val Ile Val Arg Ile Ser 
                 805                810                815
Gln Gly Phe Asp Ile Ser Gln Val Leu Gln Val Gln Glu Glu Leu Glu 
             820                825                830
Arg Leu Glu Gln Glu Arg Leu Ala Leu Glu Ala Thr Ile Lys Asp Asn 
         835                840                845
Glu Cys Glu Glu Glu Ser Gly Gly Ile Arg Gly Leu Phe Lys Lys Ala 
     850                855                860
Gly Lys Leu Asn Ile Thr Lys Thr Thr Pro Lys Lys Asp Gly Ser Ile 
 865                870                875                880
Asn Thr Ser Gln Ser Met His Val Gly Glu Phe Asn Gln Lys Leu Val 
                 885                890                895
Glu Ala Ser Thr Gln Phe Lys Lys Lys Gln Glu Lys Gly Thr Ile Asp 
             900                905                910
Val Trp Trp Leu Phe Asp Asp Gly Gly Leu Thr Leu Leu Ile Pro Tyr 
         915                920                925
Ile Leu Thr Leu Arg Lys Lys Trp Lys Asp Cys Lys Leu Arg Ile Tyr 
     930                935                940
Val Gly Gly Lys Ile Asn Arg Ile Glu Glu Glu Lys Ile Ala Met Ala 
 945                950                955                960
Ser Leu Leu Ser Lys Phe Arg Ile Lys Phe Ala Asp Ile His Ile Ile 
                 965                970                975
Gly Asp Ile Asn Ile Arg Pro Asn Lys Glu Ser Trp Lys Val Phe Glu 
             980                985                990
Glu Met Ile Glu Pro Tyr Arg Leu His Glu Ser Cys Lys Asp Leu Thr 
         995                1000                1005
Thr Ala Glu Lys Leu Lys Arg Glu Thr Pro Trp Lys Ile Thr Asp Ala 
     1010                1015                1020
Glu Leu Glu Ala Val Lys Glu Lys Ser Tyr Arg Gln Val Arg Leu Asn 
 1025                1030                1035                1040
Glu Leu Leu Gln Glu His Ser Arg Ala Ala Asn Leu Ile Val Leu Ser 
                 1045                1050                1055
Leu Pro Val Ala Arg Lys Gly Ser Ile Ser Asp Leu Leu Tyr Met Ala 
             1060                1065                1070
Trp Leu Glu Ile Leu Thr Lys Asn Leu Pro Pro Val Leu Leu Val Arg 
         1075                1080                1085
Gly Asn His Lys Asn Val Leu Thr Phe Tyr Ser 
     1090                1095



<210> 890
<211> 1028
<212> DNA
<213> Rattus norvegicus
<308> AF051895
<400> 890

gcggccgcg  cgacgttgc  cggagagta  tgcctgtct  tcggcgtgt  catctgtcc  60
gctctcaac  gcagcctgc  ccctacctt  tgcagctcc  gcctactcc  gaccgacag  120
atcatggct  tcagaggca  cgtgactga  ttctctgga  tcgacggca  ggctgatgc  180
gaagttctt  ggaaggcca  gaaaggctt  ggcaccgac  aggacagca  cctgaacct  240
ttgacagcc  ggagcaacg  tcagcgcca  cagattgct  aggagttta  gactctgtt  300
ggcagggac  ttgtgaatg  catgaagtc  gaactgacc  gaaagtttg  gaagttaat  360
gtggctttg  tgaagccct  ccggctcta  gacgcctac  agctgaaac  cgctcttaa  420
ggagctggg  cagatgaga  agtgttgac  gaaatcatt  cctcaagga  acctgaaga  480
ctcagggcc  taaaacaag  ttatgaaga  gaatatggt  ccaacctgg  agatgatgt  540
gtgggggat  cctcagggt  ctaccagag  atgttggtg  tcctccttc  ggccaatag  600
gaccctgac  ctgcaattg  tgatgctca  gttgaactg  atgctcagg  attgttcca  660
gctggagag  tgaagtggg  gacggatga  gaaaagttc  tcaccatcc  tgggacacg  720
agtgtgtct  atttaagaa  agtgtttga  aagtacatg  caatatcag  atttcagat  780
gaggaaacc  ttgaccgag  gacctcagg  aacttggag  acttactcc  ggctgtcgt  840
aagtctatt  ggagcatac  tgcctacct  gcagagacc  tctactatg  tatgaaggg  900
gctgggacg  acgatcaca  cctcatcag  gtcatagtg  cgaggagtg  gattgatct  960
tttaacatc  ggaaggagt  taggaagaa  ttcgccacg  ccctgtact  tatgatcaa  1020
ggcgacac  1028



<210> 891
<211> 302
<212> PRT
<213> Rattus norvegicus
<308> AAC06290
<400> 891

Met Ala Leu Arg Gly Thr Val Thr Asp Phe Ser Gly Phe Asp Gly Arg 
  1               5                  10                  15
Ala Asp Ala Glu Val Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp 
             20                  25                  30
Glu Asp Ser Ile Leu Asn Leu Leu Thr Ala Arg Ser Asn Ala Gln Arg 
         35                  40                  45
Gln Gln Ile Ala Glu Glu Phe Lys Thr Leu Phe Gly Arg Asp Leu Val 
     50                  55                  60
Asn Asp Met Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile Val 
 65                  70                  75                  80
Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys His 
                 85                  90                  95
Ala Leu Lys Gly Ala Gly Thr Asp Glu Lys Val Leu Thr Glu Ile Ile 
             100                105                110
Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Ala Tyr Glu 
         115                120                125
Glu Glu Tyr Gly Ser Asn Leu Glu Asp Asp Val Val Gly Asp Thr Ser 
     130                135                140
Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn Arg Asp 
 145                150                155                160
Pro Asp Thr Ala Ile Asp Asp Ala Gln Val Glu Leu Asp Ala Gln Ala 
                 165                170                175
Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu Lys Phe 
             180                185                190
Ile Thr Ile Leu Gly Thr Arg Ser Val Ser His Leu Arg Arg Val Phe 
         195                200                205
Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr Ile Asp 
     210                215                220
Arg Glu Thr Ser Gly Asn Leu Glu Asn Leu Leu Leu Ala Val Val Lys 
 225                230                235                240
Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr Tyr Ala 
                 245                250                255
Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val Ile Val 
             260                265                270
Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg Lys 
         275                280                285
Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
     290                295                300



<210> 892
<211> 1630
<212> DNA
<213> Homo sapiens
<308> NM_001154
<400> 892

agggccggg  tggggcgct  gcgtttccg  tgcttggat  agtctaggt  cagctgcgg  60
tccttcagc  tctgcatct  ggcgtcgcc  cgcgtaccg  cgcccggct  tccgccgct  120
tcccggggg  tcggggcac  tgggtccca  agtctggtc  tgcttcacc  tcccctgac  180
tgagtagtc  ccatggcac  ggttctcag  ggcactgtg  ctgacttcc  tggatttga  240
gagcgggct  atgcagaaa  tcttcggaa  gctatgaaa  gcttgggca  agatgagga  300
agcatcctg  ctctgttga  atcccgaag  aatgctcag  gccaggaaa  ctctgcagc  360
tttaagact  tgtttggca  ggatcttct  gatgacctg  aatcagaac  aactggaaa  420
tttgaaaaa  taattgtgg  tctgatgaa  ccctctcgg  tttatgatg  ttatgaact  480
aaacatgcc  tgaagggag  tggaacaaa  gaaaaagta  tgacagaaa  tattgcttc  540
aggacacct  aagaactga  agccatcaa  caagtttat  aagaagaat  tggctcaag  600
ctggaagat  acgtggtgg  ggacacttc  gggtactac  agcggatgt  ggtggttct  660
cttcaggct  acagagacc  tgatgctgg  attgatgaa  ctcaagttg  acaagatgc  720
caggcttta  ttcaggctg  agaacttaa  tgggggaca  atgaagaaa  gtttatcac  780
atctttgga  cacgaagtg  gtctcattt  agaaaggtg  ttgacaagt  catgactat  840
tcaggattt  aaattgagg  aaccattga  cgcgagact  ctggcaatt  agagcaact  900
ctccttgct  ttgtgaaat  tattcgaag  atacctgcc  accttgcag  gaccctcta  960
tatgctatg  agggagctg  gacagatga  cataccctc  tcagagtca  ggtttccag  1020
agtgagatt  atctgttta  catcaggaa  gagtttagg  agaattttg  cacctctct  1080
tattccatg  ttaagggag  tacatctgg  gactataag  aagctcttc  gctgctctg  1140
ggagaagat  actaacgtg  cacggggaa  agctccctg  tgtgtgcct  caccacccc  1200
ctgccttcc  tcagcacct  tagctgcat  tgtatgcca  tgcttaaca  attgcctta  1260
tcatactag  atgctcatg  ccaacacat  cacgtcata  aagaaaata  tggtgcttc  1320
ttctgatct  tagtggaga  ctctttgac  gctgtagta  taaagtgta  ttaatgtta  1380
taagtttaa  gcctggcca  tttccattt  tatatattt  ttaagaggc  agagtgctt  1440
tagcctttt  taaaaactc  atttatatt  catttgtaa  catgatact  taattagaa  1500
cttagcctt  aaattgtga  ctcttggaa  tgttattag  gaagttcgc  actaaacta  1560
acctgtaaa  ttatgatga  tgtattcaa  agattaatg  aaaataaac  tttctgtcc  1620
cctgaattat  1630



<210> 893
<211> 319
<212> PRT
<213> Homo sapiens
<308> P08758
<400> 893

Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp Glu 
  1               5                  10                  15
Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly Thr 
             20                  25                  30
Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala Gln 
         35                  40                  45
Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp Leu 
     50                  55                  60
Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile 
 65                  70                  75                  80
Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys 
                 85                  90                  95
His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu Ile 
             100                105                110
Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val Tyr 
         115                120                125
Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp Thr 
     130                135                140
Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn Arg 
 145                150                155                160
Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala Gln 
                 165                170                175
Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu Lys 
             180                185                190
Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys Val 
         195                200                205
Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr Ile 
     210                215                220
Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val Val 
 225                230                235                240
Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr Tyr 
                 245                250                255
Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val Met 
             260                265                270
Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg 
         275                280                285
Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr Ser 
     290                295                300
Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
 305                310                315



<210> 894
<211> 2472
<212> DNA
<213> Rattus norvegicus
<308> AF052042
<400> 894

gaactaaaa  gatcgtgtg  gcggatgtg  tgtgtctgt  gtgactttt  ccgggcctc  60
tttttggga  aaggtacca  tctgcctcg  tgaggcaga  aaggtccgt  atgccattg  120
gctttgccc  tctagaaaa  aagctctag  tggacggtc  agaggctcc  atggctgcg  180
gctctgggg  cgccccgcc  cctctcggc  ttgggcttt  tgcggtgaa  gtggaggag  240
actctcccg  gagtcagga  ccctccggt  ccggagatt  gcagaatcc  gaaacttct  300
gaaaacagt  cagacaatt  cgctaccag  aagtagccg  ccctgagga  gcgctgagc  360
gactttggg  gctctgtcg  cggtggctg  ggccggagc  gcgctccaa  gagcagatc  420
tggagctac  ggtgctgga  cagtttctt  ccatcctgc  tcgggagct  caggcctac  480
tgcgggacc  ctgccctga  agcggggag  aggctgcgg  tttggcgcg  actctgcaa  540
gagcactgg  cggggcctc  ctccagagc  ttgcaactt  caaggatgt  gctgaatct  600
tgacctggg  agagtggga  cagctggct  cagctcgga  gggtttctg  cgagagagc  660
caaaggacc  tgggagtac  gttggccct  gcttggaaa  caaagctgt  accacagac  720
tgattctaa  gcaagaaat  tcaaaggag  cagagtccc  ggcatggct  caagaagtg  780
cccagggaa  ggtcccagt  tttaccaaa  gtggtgata  ctgggagga  tgggaggaa  840
ggcttccaa  agctgccga  ttgctgccg  tccagagtt  tcctgaaga  caaggacgc  900
ctgccatcc  gcatctcct  ggcgtgtcc  aagatgaaa  cgattctaa  gataatgaa  960
ttgagaaca  cggcagctt  gtccttggt  agcacatcc  gacagcaga  ggtctggtc  1020
ccaatggtg  atgtgggga  gatcacaaa  aaggcttac  tgcgaaatg  cacacggtg  1080
agcctcaca  ctctgttga  aatgctttg  ggcttcttg  gagccagag  catttccaa  1140
aaggcagac  ttataagtg  gataactgc  agaagagat  cagacagcg  tcagacctc  1200
tcaaacacc  gaggactca  acaggtgag  aaccctatc  gtgccaaga  tgtgggaaa  1260
gcttcagtc  gagtgctgc  ctggtgaaa  accagcgga  acacacagg  gagaagcca  1320
atgcatgcc  agaatgcgg  gaatgcttc  ggcagagct  acacctcag  cggcatcag  1380
gaacccatg  cagcgagaa  tactgtaaa  gtgaggagt  tggggagat  tttcatatc  1440
ccagcttat  taaacatca  agactgcat  aaggggaga  accacacaa  tgtgaagtc  1500
gtgagaaga  ctttaaaca  cgctcagac  tctttaagc  ccagagaat  catacagga  1560
agaagccct  catgtgctt  gtctgtgag  gaagattca  tcagagtgc  accctcatt  1620
aacaccagc  aactcacac  ggagaaaaa  cttataaat  ttttcaatg  ggcgaaaga  1680
ttagacaga  tacacacct  gtccgacac  aaagaatcc  tcacaattc  gtctctggg  1740
ttagggtgg  gaagcaaca  ggtaacctc  tgagctggt  accctctgg  tgcaaagaa  1800
ggaaatgcc  cattcgcct  gcgcactga  ccatcgagg  agaaattga  ccctccaca  1860
ctgcagttt  tgcgccagg  acaactagc  cagtggcag  aaacactgc  acagcggcg  1920
acctggaac  tcgtgaccc  ccccccccc  gggcatcgg  gccctggtg  tagctattt  1980
tggttacac  ttctactca  tggcccagg  acatttcct  gatgagctg  aagatgaag  2040
caaagatgc  cgagcccga  ctcttgaga  agagagaga  catcaggac  ctaactgta  2100
ggaccatcc  gaaactgct  gagcccccg  acatgttga  tgatgcctg  tggtctcac  2160
gcatcactg  cataggaac  gtggactat  attgagccc  agaagccac  gactatgca  2220
ttggctact  ccaagggga  attgctcac  tcacatgca  tttgtacat  tactcagcc  2280
ctttttatt  ccttgtttg  gaggtatgc  cgaccttgc  tttccccaa  ctctgtggt  2340
tacctcttc  cctcccagg  gcccaactg  taaggggga  ggtgtggcc  aactgcaga  2400
ttggaacca  agtgggaaa  atagggtca  gtaaagagt  attaaaaaa  aaaaaaaaa  2460
aaaaaaaaa  aa  2472



<210> 895
<211> 536
<212> PRT
<213> Rattus norvegicus
<308> Q9Z2K3
<400> 895

Met Ala Ala Gly Ser Gly Val Ala Pro Pro Pro Leu Gly Val Gly Leu 
  1               5                  10                  15
Cys Ala Val Lys Val Glu Glu Asp Ser Pro Gly Ser Gln Glu Pro Ser 
             20                  25                  30
Gly Ser Gly Asp Trp Gln Asn Pro Glu Thr Ser Arg Lys Gln Phe Arg 
         35                  40                  45
Gln Leu Arg Tyr Gln Glu Val Ala Gly Pro Glu Glu Ala Leu Ser Arg 
     50                  55                  60
Leu Trp Glu Leu Cys Arg Arg Trp Leu Arg Pro Glu Leu Arg Ser Lys 
 65                  70                  75                  80
Glu Gln Ile Met Glu Leu Leu Val Leu Glu Gln Phe Leu Thr Ile Leu 
                 85                  90                  95
Pro Arg Glu Leu Gln Ala Tyr Val Arg Asp His Cys Pro Glu Ser Gly 
             100                105                110
Glu Glu Ala Ala Ala Leu Ala Arg Thr Leu Gln Arg Ala Leu Asp Gly 
         115                120                125
Ala Ser Leu Gln Ser Phe Ala Thr Phe Lys Asp Val Ala Glu Ser Leu 
     130                135                140
Thr Trp Glu Glu Trp Glu Gln Leu Ala Ala Ala Arg Lys Gly Phe Cys 
 145                150                155                160
Arg Glu Ser Thr Lys Asp Pro Gly Ser Thr Val Gly Pro Gly Leu Glu 
                 165                170                175
Thr Lys Ala Val Thr Thr Asp Val Ile Leu Lys Gln Glu Met Ser Lys 
             180                185                190
Glu Ala Glu Ser Gln Ala Trp Leu Gln Glu Val Ser Gln Gly Lys Val 
         195                200                205
Pro Val Phe Thr Lys Cys Gly Asp Thr Trp Glu Asp Trp Glu Glu Arg 
     210                215                220
Leu Pro Lys Ala Ala Glu Leu Leu Pro Leu Gln Ser Ser Pro Glu Glu 
 225                230                235                240
Gln Gly Arg Thr Ala Ile Pro His Leu Leu Gly Val Ser Lys Asp Glu 
                 245                250                255
Ser Asp Ser Lys Asp Asn Glu Phe Glu Asn Ser Gly Ser Leu Val Leu 
             260                265                270
Gly Gln His Ile Gln Thr Ala Glu Gly Leu Val Thr Asn Gly Glu Cys 
         275                280                285
Gly Glu Asp His Lys Gln Gly Leu His Ala Lys Cys His Thr Val Lys 
     290                295                300
Pro His Ser Ser Val Asp Asn Ala Leu Gly Leu Leu Glu Ser Gln Arg 
 305                310                315                320
His Phe Gln Glu Gly Arg Pro Tyr Lys Cys Asp Asn Cys Glu Lys Arg 
                 325                330                335
Phe Arg Gln Arg Ser Asp Leu Phe Lys His Gln Arg Thr His Thr Gly 
             340                345                350
Glu Lys Pro Tyr Gln Cys Gln Glu Cys Gly Lys Ser Phe Ser Gln Ser 
         355                360                365
Ala Ala Leu Val Lys His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
     370                375                380
Ala Cys Pro Glu Cys Gly Glu Cys Phe Arg Gln Ser Ser His Leu Ser 
 385                390                395                400
Arg His Gln Arg Thr His Gly Ser Glu Lys Tyr Cys Lys Cys Glu Glu 
                 405                410                415
Cys Gly Glu Ile Phe His Ile Ser Ser Leu Phe Lys His Gln Arg Leu 
             420                425                430
His Lys Gly Glu Arg Pro His Lys Cys Glu Val Cys Glu Lys Ser Phe 
         435                440                445
Lys Gln Arg Ser Asp Leu Phe Lys His Gln Arg Ile His Thr Gly Glu 
     450                455                460
Lys Pro Tyr Met Cys Phe Val Cys Glu Arg Arg Phe Ser Gln Ser Ala 
 465                470                475                480
Thr Leu Ile Lys His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys 
                 485                490                495
Cys Phe Gln Cys Gly Glu Arg Phe Arg Gln Ser Thr His Leu Val Arg 
             500                505                510
His Gln Arg Ile His His Asn Ser Val Ser Gly Leu Arg Val Glu Lys 
         515                520                525
Gln His Gly Asn Leu Leu Ser Trp 
     530                535



<210> 896
<211> 793
<212> DNA
<213> Homo sapiens
<308> NM_014019
<400> 896

gggaaggag  agtggcaac  tggcgtctt  gggagctgg  gaccctctg  attctaagc  60
tggagaggc  ccgttcgct  agcgtatcg  cccgactcg  gagaagctg  cacccgagc  120
actgcattc  atgcggcag  cggagcttg  ccagtggca  aaggtccta  cacggcggc  180
aacccggaa  atcgtgacc  gcctaggca  cggggccct  gtgttggct  tttatggtt  240
caccttcta  tcgatttcc  aggagcgtt  cctagatga  ctagaagac  aggccaaag  300
tgcccgagc  cgagctctg  caagggcgt  agggtccta  tctggatgg  tattgatca  360
gtccaacct  ctggagccc  ttcacatgg  ggatgatgc  ccatgaccc  gtagaaatt  420
aatcctgct  acaacattg  tggccttct  actaacctt  gaccgtgat  gagcccaag  480
aaccaggga  ttacgcatt  ggccaatgt  aaaagaaca  aactttgcc  actgcacac  540
tgctgtgta  aatgactga  ccctttctt  tagtttgtt  ccttgtttg  gaggtgtgc  600
tgcgaccgt  gcttttccc  aagtttctg  ctttgtggt  taccccctt  accttccag  660
gacgcagtt  ttacgaggt  agacgtggc  gctctgtgc  gtgtttgag  ctacagtgg  720
atacatagg  tcaaattga  aataataaa  tgagtcatt  tcctggaaa  aaaaaaaaa  780
aaaaaaaaa  aaa  793



<210> 897
<211> 561
<212> PRT
<213> Homo sapiens
<308> NP_115540
<400> 897

Met Asn Cys Ser Leu Thr Ala Gln Arg Arg Gly Ser Asp Ala Glu Leu 
  1               5                  10                  15
Gly Pro Trp Val Met Ala Ala Arg Ser Lys Asp Ala Ala Pro Ser Gln 
             20                  25                  30
Arg Asp Gly Leu Leu Pro Val Lys Val Glu Glu Asp Ser Pro Gly Ser 
         35                  40                  45
Trp Glu Pro Asn Tyr Pro Ala Ala Ser Pro Asp Pro Glu Thr Ser Arg 
     50                  55                  60
Leu His Phe Arg Gln Leu Arg Tyr Gln Glu Val Ala Gly Pro Glu Glu 
 65                  70                  75                  80
Ala Leu Ser Arg Leu Arg Glu Leu Cys Arg Arg Trp Leu Arg Pro Glu 
                 85                  90                  95
Leu Leu Ser Lys Glu Gln Ile Leu Glu Leu Leu Val Leu Glu Gln Phe 
             100                105                110
Leu Thr Ile Leu Pro Glu Glu Leu Gln Ala Trp Val Arg Glu His Cys 
         115                120                125
Pro Glu Ser Gly Glu Glu Ala Val Ala Val Val Arg Ala Leu Gln Arg 
     130                135                140
Ala Leu Asp Gly Thr Ser Ser Gln Gly Met Val Thr Phe Glu Asp Thr 
 145                150                155                160
Ala Val Ser Leu Thr Trp Glu Glu Trp Glu Arg Leu Asp Pro Ala Arg 
                 165                170                175
Arg Asp Phe Cys Arg Glu Ser Ala Gln Lys Asp Ser Gly Ser Thr Val 
             180                185                190
Pro Pro Ser Leu Glu Ser Arg Val Glu Asn Lys Glu Leu Ile Pro Met 
         195                200                205
Gln Gln Ile Leu Glu Glu Ala Glu Pro Gln Gly Gln Leu Gln Glu Ala 
     210                215                220
Phe Gln Gly Lys Arg Pro Leu Phe Ser Lys Cys Gly Ser Thr His Glu 
 225                230                235                240
Asp Arg Val Glu Lys Gln Ser Gly Asp Pro Leu Pro Leu Lys Leu Glu 
                 245                250                255
Asn Ser Pro Glu Ala Glu Gly Leu Asn Ser Ile Ser Asp Val Asn Lys 
             260                265                270
Asn Gly Ser Ile Glu Gly Glu Asp Ser Lys Asn Asn Glu Leu Gln Asn 
         275                280                285
Ser Ala Arg Cys Ser Asn Leu Val Leu Cys Gln His Ile Pro Lys Ala 
     290                295                300
Glu Arg Pro Thr Asp Ser Glu Glu His Gly Asn Lys Cys Lys Gln Ser 
 305                310                315                320
Phe His Met Val Thr Trp His Val Leu Lys Pro His Lys Ser Asp Ser 
                 325                330                335
Gly Asp Ser Phe His His Ser Ser Leu Phe Glu Thr Gln Arg Gln Leu 
             340                345                350
His Glu Glu Arg Pro Tyr Lys Cys Gly Asn Cys Gly Lys Ser Phe Lys 
         355                360                365
Gln Arg Ser Asp Leu Phe Arg His Gln Arg Ile His Thr Gly Glu Lys 
     370                375                380
Pro Tyr Gly Cys Gln Glu Cys Gly Lys Ser Phe Ser Gln Ser Ala Ala 
 385                390                395                400
Leu Thr Lys His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Thr Cys 
                 405                410                415
Leu Lys Cys Gly Glu Arg Phe Arg Gln Asn Ser His Leu Asn Arg His 
             420                425                430
Gln Ser Thr His Ser Arg Asp Lys His Phe Lys Cys Glu Glu Cys Gly 
         435                440                445
Glu Thr Cys His Ile Ser Asn Leu Phe Arg His Gln Arg Leu His Lys 
     450                455                460
Gly Glu Arg Pro Tyr Lys Cys Glu Glu Cys Glu Lys Ser Phe Lys Gln 
 465                470                475                480
Arg Ser Asp Leu Phe Lys His His Arg Ile His Thr Gly Glu Lys Pro 
                 485                490                495
Tyr Gly Cys Ser Val Cys Gly Lys Arg Phe Asn Gln Ser Ala Thr Leu 
             500                505                510
Ile Lys His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Leu 
         515                520                525
Glu Cys Gly Glu Arg Phe Arg Gln Ser Thr His Leu Ile Arg His Gln 
     530                535                540
Arg Ile His Gln Asn Lys Val Leu Ser Ala Gly Arg Gly Gly Ser Arg 
 545                550                555                560
Leu 
                 565



<210> 898
<211> 1416
<212> DNA
<213> Rattus norvegicus
<308> AF054618
<400> 898

atgtggaaa  cctctgcag  ccatgctgt  tccatcacc  aggatgatg  ggaagccga  60
gactgggag  ctgaccctg  ttttgtgaa  gatgtgagt  aaaaggaac  gagatgggg  120
gccaaaacc  tgcagggat  ggggcacca  gaacacatc  acatacaca  gcttcgaga  180
aatgtcttc  aagaacacc  gacactcaa  gagaatgag  tggaaacgg  acccaaggc  240
tcccatggc  atggcggga  gtttggtgt  gagcaagat  ggatggaca  atcagctgt  300
ggccatgag  accagtcaa  gctctccaa  cactgctca  aagtggact  agtccgggg  360
ttcggaggc  agttcggtg  ccagatgga  agggtggat  agtctgctg  aggctttga  420
taccagggg  agacggaga  gcacgcctc  cagaaagac  actccagtg  tttcggtgg  480
aaatatgga  tgcaagctg  ccgtgtaga  aagagtgct  tggggtttg  ctaccaggg  540
aagacggag  agcacgagt  acagaaaga  tactccaaa  gttttggtg  caaatacgg  600
attgacaag  acaaggtgg  taaaagcgc  gtgggcttt  agtatcaag  caaaacaga  660
aagcatgag  cccagaaag  ctatgtaaa  ggctttgga  gaaagtttg  tgtgcagaa  720
gatcggatg  acaagaacg  atccacctt  gaagaagtg  tccaggtgc  gtctgccta  780
cagaagact  tccccattg  ggctgtgac  agcaaaacc  gtaatattc  tgctaactt  840
gaaagcctg  caaaggaga  agagcagga  gacagacgg  aggcagaag  cgagagagc  900
cagcggatg  cccaagaaa  gcaggagca  gaggctcga  ggaagctgg  agagcaagc  960
agagccaag  agcagacac  ccctgcatc  cctagtcct  agccagctg  agacagacc  1020
ccatccagc  ccatctatg  ggatacagc  ccgttgaag  ccgagccca  ctacggaag  1080
agtgagcct  agcctgagt  cagcactga  gctgcaggc  ttcctgagg  cagcaacca  1140
caaggtctg  cctacacat  agagcctgt  tacgagacc  cagaggttc  tggccacta  1200
caagcagag  atgacacct  cgatgggta  gagagtgac  tgggcatca  agccatcgc  1260
ctgtatgac  accaggctg  tggcgatga  gaaatctcc  ttgaccctg  tgatgtcat  1320
accaacata  aaatgattg  cgatggctg  tggcgtggg  tgtgcaaag  cagatatgg  1380
ctcttcccg  ccaactatg  ggagctgcg  cagtag  1416



<210> 899
<211> 471
<212> PRT
<213> Rattus norvegicus
<308> AAC08424
<400> 899

Met Trp Lys Ala Ser Ala Gly His Ala Val Ser Ile Thr Gln Asp Asp 
  1               5                  10                  15
Gly Glu Ala Asp Asp Trp Glu Thr Asp Pro Asp Phe Val Asn Asp Val 
             20                  25                  30
Ser Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Val Gln Gly Ser Gly 
         35                  40                  45
His Gln Glu His Ile Asn Ile His Lys Leu Arg Glu Asn Val Phe Gln 
     50                  55                  60
Glu His Gln Thr Leu Lys Glu Asn Glu Leu Glu Thr Gly Pro Lys Ala 
 65                  70                  75                  80
Ser His Gly Tyr Gly Gly Lys Phe Gly Val Glu Gln Asp Arg Met Asp 
                 85                  90                  95
Lys Ser Ala Val Gly His Glu Tyr Gln Ser Lys Leu Ser Lys His Cys 
             100                105                110
Ser Gln Val Asp Ser Val Arg Gly Phe Gly Gly Lys Phe Gly Val Gln 
         115                120                125
Met Asp Arg Val Asp Gln Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys 
     130                135                140
Thr Glu Lys His Ala Ser Gln Lys Asp Tyr Ser Ser Gly Phe Gly Gly 
 145                150                155                160
Lys Tyr Gly Val Gln Ala Asp Arg Val Asp Lys Ser Ala Val Gly Phe 
                 165                170                175
Asp Tyr Gln Gly Lys Thr Glu Lys His Glu Ser Gln Lys Asp Tyr Ser 
             180                185                190
Lys Gly Phe Gly Gly Lys Tyr Gly Ile Asp Lys Asp Lys Val Asp Lys 
         195                200                205
Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys Thr Glu Lys His Glu Ser 
     210                215                220
Gln Lys Asp Tyr Val Lys Gly Phe Gly Gly Lys Phe Gly Val Gln Lys 
 225                230                235                240
Asp Arg Met Asp Lys Asn Ala Ser Thr Phe Glu Glu Val Val Gln Val 
                 245                250                255
Pro Ser Ala Tyr Gln Lys Thr Val Pro Ile Glu Ala Val Thr Ser Lys 
             260                265                270
Thr Ser Asn Ile Arg Ala Asn Phe Glu Ser Leu Ala Lys Glu Arg Glu 
         275                280                285
Gln Glu Asp Arg Arg Lys Ala Glu Ala Glu Arg Ala Gln Arg Met Ala 
     290                295                300
Gln Glu Arg Gln Glu Gln Glu Ala Arg Arg Lys Leu Glu Glu Gln Ala 
 305                310                315                320
Arg Ala Lys Lys Gln Thr Pro Pro Ala Ser Pro Ser Pro Gln Pro Ala 
                 325                330                335
Glu Asp Arg Pro Pro Ser Ser Pro Ile Tyr Glu Asp Thr Ala Pro Leu 
             340                345                350
Lys Ala Glu Pro Ser Tyr Gly Ser Ser Glu Pro Glu Pro Glu Tyr Ser 
         355                360                365
Thr Glu Ala Ala Gly Leu Pro Glu Ala Ser Asn Gln Gln Gly Leu Ala 
     370                375                380
Tyr Thr Ser Glu Pro Val Tyr Glu Thr Thr Glu Val Pro Gly His Tyr 
 385                390                395                400
Gln Ala Glu Asp Asp Thr Tyr Asp Gly Tyr Glu Ser Asp Leu Gly Ile 
                 405                410                415
Thr Ala Ile Ala Leu Tyr Asp Tyr Gln Ala Ala Gly Asp Asp Glu Ile 
             420                425                430
Ser Phe Asp Pro Asp Asp Val Ile Thr Asn Ile Glu Met Ile Asp Asp 
         435                440                445
Gly Trp Trp Arg Gly Val Cys Lys Gly Arg Tyr Gly Leu Phe Pro Ala 
     450                455                460
Asn Tyr Val Glu Leu Arg Gln 
 465                470



<210> 900
<211> 2067
<212> DNA
<213> Homo sapiens
<308> AK023333
<400> 900

attgatcgg  agaaagcta  cttcccccc  aggctagaa  ccagagttg  taaattctt  60
ttttcctta  acacatacg  tcttaactg  tggtgatta  tcttgatta  atcatgcag  120
ctcttttct  aaagaccaa  gcatatcgc  accttaaag  tctcagttt  ttttttgca  180
gcttattta  ttcttcctc  tttgtgtca  tgcatcatc  gcggaacaa  ctctcagtc  240
ttacgcagt  tcggtgcag  ctaggtgga  gtagctgtg  tgtgggcag  cggaggatc  300
gggtcttgt  tcccatgtt  agctgcatg  ctttcttca  atgaggctt  ctctttcca  360
ttttttcat  ttgttttgt  tgtttgttt  ttttgagac  gagtctcgc  ctgttgccc  420
ggctggagt  cagtggcac  atctcggct  actgcaacc  gcgcctcct  ggttcaaac  480
attctcctg  ctcagcctc  caagtagct  ggattacag  tgtgtgcca  tacccctgg  540
tagtttttc  attttttag  aaagatggg  ttttgccac  ttggccagg  tggtctcaa  600
ctcctggcc  caagtgatc  gcccacctc  gcctccaaa  tgctggttc  ttgtatgaa  660
ctttccagc  tttacctga  cagttgatt  tcaaagtgg  catgcagcg  catttctga  720
tacacaaag  aactgccct  taacagctg  cagggccca  aaccccccc  tgcacctgt  780
gtgaaacag  gtccagcgt  acctgtatg  agcagtggg  ggcttgttg  acattttaa  840
atgtgcgct  gatgtgttt  tgagttgta  cccctacac  cttttgctt  gtttaacaa  900
aggaacagt  tagttcgtc  tcaggcccc  gtgctaatt  ctgccctgt  tctccagac  960
actccagtg  ttttggcgg  aagtatggc  tgcaggccg  ccgagtaga  aagagcgcg  1020
tgggcttcg  ctaccaggg  aagacggag  agcacgagt  acagagagg  ggggcggac  1080
ccacggtct  taatcacgc  tttgctcca  aaacaccca  gagggcatt  tctctctgc  1140
cacgtgatt  ttgtagatt  tttaactga  aatgtttgg  gttcttttc  taccagtgt  1200
tgtgggctt  tcctaattc  aatggctgc  cagttcccc  tcgtatgag  attccatag  1260
ccatgtaac  attcctttt  tgaatgtgg  atttaggtt  tttatttat  tatttattt  1320
tttttggta  agatgaggt  ttgccgtgt  gcccggact  gtcttgatc  ccgtggtct  1380
aagcaatcc  ccccaacct  ggtttcctt  agtgctggg  ttacaggtg  gacctgtaa  1440
ttttttttt  tttttcttt  agacggagt  tcgctccgt  gcccaggct  gagtgtagt  1500
gcgtgatct  tgctcactg  aacctccac  tccctggtt  aagcaattc  cgtgcttca  1560
cctcccggc  agccgggat  acaagcaca  gccaccacg  ccagctaat  tttgtattt  1620
tagtagaga  ggagttctg  catgttgcc  aggctggtc  tgaattcct  acctcaggt  1680
atcgccctg  cttggcctc  caaagtgct  ggattacag  tgtgagcca  tgcgcccag  1740
tgaaacttg  ctgcaggga  cattcttgt  cctgtgttt  gttcacaag  gattattca  1800
aagaatcaa  tcctagaca  ggaattgct  ggtcgaagg  tattgaatg  aaaatttcc  1860
tagatactg  caagttgtc  ttggaggct  tgctgagtt  ttccttccc  actgcatag  1920
ctgtacacc  tcactcaga  cgtttccca  ggctgcaga  gccgtggcc  gcctgtttc  1980
ctgtgcctc  tgtttggcc  gcacattta  atttttaaa  atatttgcc  acatttgaa  2040
agtgagagc  tgactattt  aaaactc  2067



<210> 901
<211> 513
<212> PRT
<213> Homo sapiens
<308> AAH08799
<400> 901

Met Trp Lys Ala Ser Ala Gly His Ala Val Ser Ile Ala Gln Asp Asp 
  1               5                  10                  15
Ala Gly Ala Asp Asp Trp Glu Thr Asp Pro Asp Phe Val Asn Asp Val 
             20                  25                  30
Ser Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Val Gln Gly Ser Gly 
         35                  40                  45
His Gln Glu His Ile Asn Ile His Lys Leu Arg Glu Asn Val Phe Gln 
     50                  55                  60
Glu His Gln Thr Leu Lys Glu Lys Glu Leu Glu Thr Gly Pro Lys Ala 
 65                  70                  75                  80
Ser His Gly Tyr Gly Gly Lys Phe Gly Val Glu Gln Asp Arg Met Asp 
                 85                  90                  95
Lys Ser Ala Val Gly His Glu Tyr Gln Ser Lys Leu Ser Lys His Cys 
             100                105                110
Ser Gln Val Asp Ser Val Arg Gly Phe Gly Gly Lys Phe Gly Val Gln 
         115                120                125
Met Asp Arg Val Asp Gln Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys 
     130                135                140
Thr Glu Lys His Ala Ser Gln Lys Asp Tyr Ser Ser Gly Phe Gly Gly 
 145                150                155                160
Lys Tyr Gly Val Gln Ala Asp Arg Val Asp Lys Ser Ala Val Gly Phe 
                 165                170                175
Asp Tyr Gln Gly Lys Thr Glu Lys His Glu Ser Gln Arg Asp Tyr Ser 
             180                185                190
Lys Gly Phe Gly Gly Lys Tyr Gly Ile Asp Lys Asp Lys Val Asp Lys 
         195                200                205
Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys Thr Glu Lys His Glu Ser 
     210                215                220
Gln Lys Asp Tyr Val Lys Gly Phe Gly Gly Lys Phe Gly Val Gln Thr 
 225                230                235                240
Asp Arg Gln Asp Lys Cys Ala Leu Gly Trp Asp His Gln Glu Lys Leu 
                 245                250                255
Gln Leu His Glu Ser Gln Lys Asp Tyr Ser Lys Gly Phe Gly Gly Lys 
             260                265                270
Tyr Gly Val Gln Lys Asp Arg Met Asp Lys Asn Ala Ser Thr Phe Glu 
         275                280                285
Asp Val Thr Gln Val Ser Ser Ala Tyr Gln Lys Thr Val Pro Val Glu 
     290                295                300
Ala Val Thr Ser Lys Thr Ser Asn Ile Arg Ala Asn Phe Glu Asn Leu 
 305                310                315                320
Ala Lys Glu Lys Glu Gln Glu Asp Arg Arg Lys Ala Glu Ala Glu Arg 
                 325                330                335
Ala Gln Arg Met Ala Lys Glu Arg Gln Glu Gln Glu Glu Ala Arg Arg 
             340                345                350
Lys Leu Glu Glu Gln Ala Arg Ala Lys Thr Gln Thr Pro Pro Val Ser 
         355                360                365
Pro Ala Pro Gln Pro Thr Glu Glu Arg Leu Pro Ser Ser Pro Val Tyr 
     370                375                380
Glu Asp Ala Ala Ser Phe Lys Ala Glu Leu Ser Tyr Arg Gly Pro Val 
 385                390                395                400
Ser Gly Thr Glu Pro Glu Pro Val Tyr Ser Met Glu Ala Ala Asp Tyr 
                 405                410                415
Arg Glu Ala Ser Ser Gln Gln Gly Leu Ala Tyr Ala Thr Glu Ala Val 
             420                425                430
Tyr Glu Ser Ala Glu Ala Pro Gly His Tyr Pro Ala Glu Asp Ser Thr 
         435                440                445
Tyr Asp Glu Tyr Glu Asn Asp Leu Gly Ile Thr Ala Val Ala Leu Tyr 
     450                455                460
Asp Tyr Gln Ala Ala Gly Asp Asp Glu Ile Ser Phe Asp Pro Asp Asp 
 465                470                475                480
Ile Ile Thr Asn Ile Glu Met Ile Asp Asp Gly Trp Trp Arg Gly Val 
                 485                490                495
Cys Lys Gly Arg Tyr Gly Leu Phe Pro Ala Asn Tyr Val Glu Leu Arg 
             500                505                510
Gln 
         515



<210> 902
<211> 422
<212> DNA
<213> Rattus norvegicus
<308> AF055292
<400> 902

actctgaac  tcaagttta  ggctgaggt  gggaccagc  ggggactgc  accagaaca  60
ttcctgttc  tggcccaga  gatcttcaa  gacaacagc  ttagcatag  ggcctttca  120
caccgctgt  tgtcttggt  acagttcaa  aaggagatt  tactgggcc  aggcttcac  180
ttttggcag  ggtttgatg  tgtcctgga  ctcactaaa  gctgtcttc  gagctactg  240
tcagatcgg  tgatcatcg  ctttatcag  aagcaatat  tcactagcc  tctcctcaa  300
gagccagat  gaaccttcc  cctccgctt  agcgactct  agattgggg  catcaccat  360
gcccatgtc  tccggggtc  ggatggctc  tcacagata  agaacatcc  gccgttttc  420
gc  422



<210> 903
<211> 141
<212> PRT
<213> Rattus norvegicus
<308> AAC12759
<400> 903

Thr Leu Asn Leu Lys Phe Met Ala Glu Val Gly Thr Ser Arg Gly Leu 
  1               5                  10                  15
Leu Pro Glu His Phe Leu Phe Leu Ala Gln Lys Ile Phe Asn Asp Asn 
             20                  25                  30
Ser Leu Ser Ile Glu Ala Phe Gln His Arg Cys Val Ser Trp Ser Gln 
         35                  40                  45
Phe Asn Lys Glu Ile Leu Leu Gly Arg Gly Phe Thr Phe Trp Gln Trp 
     50                  55                  60
Phe Asp Gly Val Leu Asp Leu Thr Lys Arg Cys Leu Arg Ser Tyr Trp 
 65                  70                  75                  80
Ser Asp Arg Leu Ile Ile Gly Phe Ile Ser Lys Gln Tyr Val Thr Ser 
                 85                  90                  95
Leu Leu Leu Asn Glu Pro Asp Gly Thr Phe Leu Leu Arg Phe Ser Asp 
             100                105                110
Ser Glu Ile Gly Gly Ile Thr Ile Ala His Val Ile Arg Gly Gln Asp 
         115                120                125
Gly Ser Ser Gln Ile Glu Asn Ile Gln Pro Phe Ser Ala 
     130                135                140



<210> 904
<211> 2225
<212> DNA
<213> Rattus norvegicus
<308> AF058787
<400> 904

tttcaggga  ttttgcgat  cctctctgt  gacttctac  tgttctcta  gggagttct  60
catgtcttt  ttgaagtca  ccagcatca  gatcaaata  gattttgaa  ctagatctt  120
cttttctgg  gtgtttgga  attccatgt  tgttttggt  ggagaattg  gctccgatg  180
tggcatgta  tcttggttt  tgttgcttg  tttcctgcg  ttgcctctc  ccatcagat  240
atctctagt  ttactttgt  ctgctattt  tgacagtgg  tagactgtc  tataagcct  300
tgtgtcagg  gtgctgtag  ccttttttc  tctctttca  tcagttatg  gacagagtg  360
tctgctttt  ggcgtgtag  ttttcctct  tacaggtct  cagctgttc  tgtgggcct  420
tgtcttgag  tcaccaggc  gctttcttg  agcagaaaa  ttggtcata  ctgtgatcc  480
gaggctcaa  ttcgctcgt  gggtgctgt  caggggctc  ctgcagcgg  cacaaccag  540
aagacctgt  cggcccctt  cggagcttc  gtgcaccag  gttccagat  gcctttggc  600
ttttcctct  gcgtccgag  tgtatgtac  gagagcagt  tcttctggt  tcccaggct  660
gtctgcctc  ctgaaggtt  agctctccc  cccacggga  ttgggtgca  agaactgtt  720
atccggtct  tttctttca  gttccggtg  tgtctcagg  aggtgtcgt  cctgcgccc  780
cccccatgg  accagaggc  ttatacagt  tcctcttgg  ccagggatg  gggcagggg  840
gagcagtgt  ggtggtctc  tccgtctgc  gcctcagga  tgccacctg  ccaggcggt  900
gggtctctc  ctgagaatt  catttttaa  tcattcatt  aaatgtcat  acttgatgt  960
ctgctgtcc  tctcacgcc  tcagctgta  cagtgccga  ggagtcact  aagaagaga  1020
tgaatgacc  gagtatggg  agcacagac  actcaacaa  aatgtcttc  gaggtggag  1080
ctgcggagg  cgtagatga  tcagagaag  actctatgg  atcagagaa  gaaaaccat  1140
ccaaaatag  agacttttc  gatcttctg  aggaaggga  aaaggaagc  gatgaccgg  1200
cagaaaata  ccagtttgt  aaagacttc  tgaaaggaa  cattaagaa  gagctattt  1260
agctggcca  cactgcact  tcatactca  cccctgagg  ggaaatgga  tcactgacc  1320
aggacatgg  gtacttctt  ggtgaaaac  gggaggaaa  agtgaagtg  tctgaagct  1380
cccagacgt  tgtggatca  attcactat  tagggcaaa  tgagccaga  catctggtg  1440
cccatactt  ctctactta  atgggggga  acctttcag  ggaccaggt  ctgaagaag  1500
agacccagc  ggtcccctt  actagggaa  ggactcagt  ctacctgtt  gagcatgta  1560
acaatgcta  gcaattcaa  ctattctac  gcgctagat  gaatgcctt  gacctgaat  1620
tgaagacca  agagaggat  gtggaggaa  ccaccaaag  ctttgaata  aatatgcag  1680
tattcagtg  actggacca  gcaggctcc  taccagtaa  agaaaccct  aagaatggg  1740
tctcaatac  tgatgggaa  ggaggtgta  gcaaatgtc  ctttaatgc  gctcagcca  1800
acaaaggta  cctgggagg  agcaactgc  ctttccaga  gtccatggc  ttgctgagg  1860
agcctaact  gcagctcat  ctagttgcc  gtatggcct  ggtagctgg  cttttagcc  1920
ggtactaca  gtgaagggc  tgtcaagtt  tttgcatcc  atctcaaca  cctaccact  1980
gttccttcc  cacctccac  tctgcctag  actaccacc  caggtgaca  ttttaatgt  2040
gggtttgag  aaatgagca  ccaataaaa  acagaccct  gaaaaaagt  atgacttaa  2100
tggcacggg  acacctaaa  tcacacttt  tgcttcaga  atactttct  tctctattt  2160
aacactgaa  tcgggaagt  acctactac  attaataat  aatgctaca  aatgcataa  2220
aaaaa  2225



<210> 905
<211> 290
<212> PRT
<213> Rattus norvegicus
<308> O70453
<400> 905

Met Ser Ser Glu Val Glu Thr Ala Glu Ala Val Asp Glu Ser Glu Lys 
  1               5                  10                  15
Asn Ser Met Ala Ser Glu Lys Glu Asn His Ser Lys Ile Ala Asp Phe 
             20                  25                  30
Ser Asp Leu Leu Lys Glu Gly Thr Lys Glu Ala Asp Asp Arg Ala Glu 
         35                  40                  45
Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys Glu 
     50                  55                  60
Leu Phe Lys Leu Ala Thr Thr Ala Leu Ser Tyr Ser Ala Pro Glu Glu 
 65                  70                  75                  80
Glu Met Asp Ser Leu Thr Lys Asp Met Glu Tyr Phe Phe Gly Glu Asn 
                 85                  90                  95
Trp Glu Glu Lys Val Lys Cys Ser Glu Ala Ala Gln Thr Tyr Val Asp 
             100                105                110
Gln Ile His Tyr Val Gly Gln Asn Glu Pro Glu His Leu Val Ala His 
         115                120                125
Thr Tyr Ser Thr Tyr Met Gly Gly Asn Leu Ser Gly Asp Gln Val Leu 
     130                135                140
Lys Lys Glu Thr Gln Pro Val Pro Phe Thr Arg Glu Gly Thr Gln Phe 
 145                150                155                160
Tyr Leu Phe Glu His Val Asp Asn Ala Lys Gln Phe Lys Leu Phe Tyr 
                 165                170                175
Cys Ala Arg Leu Asn Ala Leu Asp Leu Asn Leu Lys Thr Lys Glu Arg 
             180                185                190
Ile Val Glu Glu Ala Thr Lys Ala Phe Glu Tyr Asn Met Gln Ile Phe 
         195                200                205
Ser Glu Leu Asp Gln Ala Gly Ser Ile Pro Val Arg Glu Thr Leu Lys 
     210                215                220
Asn Gly Leu Ser Ile Leu Asp Gly Lys Gly Gly Val Cys Lys Cys Pro 
 225                230                235                240
Phe Asn Ala Ala Gln Pro Asp Lys Gly Thr Leu Gly Gly Ser Asn Cys 
                 245                250                255
Pro Phe Gln Met Ser Met Ala Leu Leu Arg Lys Pro Asn Leu Gln Leu 
             260                265                270
Ile Leu Val Ala Ser Met Ala Leu Val Ala Gly Leu Leu Ala Trp Tyr 
         275                280                285
Tyr Met 
     290



<210> 906
<211> 977
<212> DNA
<213> Homo sapiens
<308> D21243
<400> 906

atgtcagcg  aagtggaaa  ctcagaggg  gtagacgag  cagaaaaaa  gaactctgg  60
gccctagaa  aggagaacc  aatgagaat  gctgacctc  cggagctcc  gaaggaagg  120
accaaggaa  cacacgacc  ggcagaaaa  acccagttt  tcaaggact  cttgaaagg  180
aacattaag  aggagctgt  taagctggc  accacggca  tttacttca  atactcagc  240
ctcgaggag  aaatggagc  caacaagga  catccagcc  ttgcccctt  gtacttccc  300
atggagctg  accggaagg  ggcgctgac  aaggacatg  agtatttct  tggtgaaaa  360
tgggaggag  aggtgcagt  ccccaaggc  gcccagaag  acgtggagc  gatccacta  420
atagggcag  acgagccgg  gctactggt  gcccatgca  acacccgct  catggggga  480
ctctcgggg  gccaggtgc  gaagaaggt  gcccagcga  cactgaaac  ccccagcac  540
ggggaaggg  cccagttct  cctgtttga  aatgtggac  atgcccagc  gttcaagca  600
ctctaccgg  ccaggatga  cgccctgga  ctgaacatg  agaccaaag  gaggatcgt  660
gaggaggcc  acaaggctt  tgagtataa  atgcagata  tcaatgaac  ggaccaggc  720
ggctccaca  tggccagag  gaccttgga  gatgggttc  ctgtacacg  tgggaaagg  780
gacatgcgt  aatgccctt  ctacgctgc  gaacaagac  aaggtgccc  ggagggcag  840
agctgtccc  tccgaacag  tatggctgt  ctgaggaag  ccagcctcc  gttcatcct  900
gccgctggt  tggccctag  tgctggact  ttggcctgg  actacatgt  aagcaccca  960
catgccaca  cggtacc  977



<210> 907
<211> 316
<212> PRT
<213> Homo sapiens
<308> P30519
<400> 907

Met Ser Ala Glu Val Glu Thr Ser Glu Gly Val Asp Glu Ser Glu Lys 
  1               5                  10                  15
Lys Asn Ser Gly Ala Leu Glu Lys Glu Asn Gln Met Arg Met Ala Asp 
             20                  25                  30
Leu Ser Glu Leu Leu Lys Glu Gly Thr Lys Glu Ala His Asp Arg Ala 
         35                  40                  45
Glu Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys 
     50                  55                  60
Glu Leu Phe Lys Leu Ala Thr Thr Ala Leu Tyr Phe Thr Tyr Ser Ala 
 65                  70                  75                  80
Leu Glu Glu Glu Met Glu Arg Asn Lys Asp His Pro Ala Phe Ala Pro 
                 85                  90                  95
Leu Tyr Phe Pro Met Glu Leu His Arg Lys Glu Ala Leu Thr Lys Asp 
             100                105                110
Met Glu Tyr Phe Phe Gly Glu Asn Trp Glu Glu Gln Val Gln Cys Pro 
         115                120                125
Lys Ala Ala Gln Lys Tyr Val Glu Arg Ile His Tyr Ile Gly Gln Asn 
     130                135                140
Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Met Gly Asp 
 145                150                155                160
Leu Ser Gly Gly Gln Val Leu Lys Lys Val Ala Gln Arg Ala Leu Lys 
                 165                170                175
Leu Pro Ser Thr Gly Glu Gly Thr Gln Phe Tyr Leu Phe Glu Asn Val 
             180                185                190
Asp Asn Ala Gln Gln Phe Lys Gln Leu Tyr Arg Ala Arg Met Asn Ala 
         195                200                205
Leu Asp Leu Asn Met Lys Thr Lys Glu Arg Ile Val Glu Glu Ala Asn 
     210                215                220
Lys Ala Phe Glu Tyr Asn Met Gln Ile Phe Asn Glu Leu Asp Gln Ala 
 225                230                235                240
Gly Ser Thr Leu Ala Arg Glu Thr Leu Glu Asp Gly Phe Pro Val His 
                 245                250                255
Asp Gly Lys Gly Asp Met Arg Lys Cys Pro Phe Tyr Ala Ala Glu Gln 
             260                265                270
Asp Lys Gly Ala Leu Glu Gly Ser Ser Cys Pro Phe Arg Thr Ala Met 
         275                280                285
Ala Val Leu Arg Lys Pro Ser Leu Gln Phe Ile Leu Ala Ala Gly Val 
     290                295                300
Ala Leu Ala Ala Gly Leu Leu Ala Trp Tyr Tyr Met 
 305                310                315



<210> 908
<211> 5905
<212> DNA
<213> Rattus norvegicus
<308> AF059030
<400> 908

tctggagcc  tacggtgcc  tgatcctct  taccaggaa  acagggtga  gatggagga  60
aggtactac  cggtgatct  cccggacga  cggaatttc  gccccttca  ttccgactc  120
ctggctgcc  tagagaagc  gattgctat  caaaaggag  ggaagaagt  caaagacaa  180
gcggcagct  agccccagc  tcggcctca  cttgaccta  aggcctcca  gaagttacc  240
aagctttat  gtgacattc  ccctgagct  gtagcgaag  ctctggaag  cctggaccc  300
ttctacaaa  accataaga  attcatggt  ttgaacaag  agagaacaa  ttatcgctt  360
agcgccaag  gggccttgt  cattctggg  ccttttaat  ccctcagaa  cttaatgat  420
cgtatctct  tccattcag  ctttagcat  ttcatcatc  gcacggtga  catcaactg  480
atgttcatg  cgaattcta  ggagagaag  ttcgacaac  acattcccg  atacgtctt  540
attgggatt  atattttag  agctgtgat  aaaatattg  caagaggct  cattgtgga  600
gagttttcc  tcctccgag  tccgtggaa  tggctggac  tcattgtca  tggaacagc  660
atcgcaact  gttttccgg  cagccaagt  aatctttca  ctcttcgta  cttccgagt  720
ttcagagct  tgaaggcga  ttcagttat  tcaggtctg  aggtcatcg  aggtgccct  780
ctgcgctcg  tgaagaagc  ggtagacgt  atggtcctc  ctctcttct  cctcagcat  840
tttgccctg  tcggtcagc  gctgttcat  ggaattctg  accagaagt  tattaagca  900
aactgtggc  ccaaccctg  atccaacaa  gattgcttt  aaaaggaaa  agatagcga  960
gacttcata  tgtgtggta  ctggctcgg  agcagaccc  gtcccaatg  ttctacgtg  1020
gataaaacc  cattgaacc  agacaataa  tatacaaag  ttgacaact  tggctggtc  1080
tttctcgcc  tgttccggg  tatgactca  gactcctgg  agaggcttt  ccgacagat  1140
ctgcggacc  ctgggatct  ctttgtctt  ttcttcgtg  tggtcatct  cctgggctc  1200
ttctacctg  ttaacctaa  cctggctgt  gtcaccatg  cttatgaag  acagaacag  1260
aatgtagct  ctgagacag  ggccaagga  aaaatgttt  aggaagccc  gcagctgtt  1320
agggaggag  aggaggctc  ggttgccat  ggaattgac  gaagttccc  taattccct  1380
caagcttca  ccttttccc  gaagaagag  aagtttttc  gtagtaaga  aagaaagtc  1440
ttctttatg  gagggtcca  gacggccca  gcctcagcg  ctgattcag  ggacgatgc  1500
tctaaaaat  cacagctcc  tgagcagac  aaacgactg  cccagaact  gccagtgga  1560
ctctttgat  agcacgtgg  ccccctcca  aggcagaga  cgctgagcg  tgtcagtat  1620
ttaaccatc  ccatgcagg  acaagaaaa  ttccaggag  cttgtttcc  atgtgggaa  1680
aatttggcc  ctaagtacc  ggtgtggga  tgtagccct  agtggctgt  cataaagaa  1740
gtcctgcgg  ccatcatga  ggatccctt  actgagctg  ccatcacca  ctgcatcat  1800
atcaatacc  ttttcttag  cgtggagca  cacaacatg  atgacaact  aaagaccat  1860
ctgaaaata  gaaactggg  tttcacggg  attttcata  cggaaatgt  tctcaagat  1920
atcgcgctc  acccttacc  ctacttccg  cacggctgg  atgtttttg  cagcatcgt  1980
gccctcctg  gtctcgctg  tgtgctcta  aacacactg  ctgataaca  taggtcttt  2040
ttggcttcc  tcagagtgc  gagggtctt  aagttagcc  aatcctggc  cacgttaaa  2100
actctcatt  agatcatcg  ccactccgt  ggcgcgctt  gaaacctga  tgtggtcct  2160
actatcgtg  tcttcatct  ttctgtggt  ggcatgcgg  tcttcggca  caagtttaa  2220
aagaccgcc  acgccaccc  ggagcggcc  aggcggcgc  ggcacatgg  taatttcta  2280
cactccttc  tggtggtgt  ccgcatcct  tgtggggaa  ggatcgaga  catgtgggg  2340
tgcatgcag  atatggacg  ctccccgtt  tgcatcatt  tctttgtcc  gataatggt  2400
atcgggaag  ttgtggtgc  taacctctt  attgccttg  tgctcaatt  cttcagcaa  2460
gaggagaag  atgggagcc  ggaaggaga  accaggaaa  ccaaagtgc  gctagccct  2520
gatcggttc  gccgggcct  ctccttcat  ctgcacgct  ttcagagtt  ttgttgcaa  2580
aaatgcagg  ggaaaaact  gccaaagcc  aaagagaca  cagaaagct  tgctggtga  2640
aataaagac  caatcctcc  ggatgcgag  ccctggaag  agtatgata  agacatggc  2700
ttgtacact  gacaggccg  ggctccgct  gccccactc  cagaggtag  ggacgatgt  2760
gaatattgt  gtgaaggcg  tgccctacc  acctcacaa  atagtgctg  agttcaggc  2820
ggtgacctc  ctccagaga  caagcagct  actagcccg  atgaccaag  ggttgaaat  2880
gaagtattt  ctgaagaag  tctgcattt  agcatacag  gtcctcgaa  gaagtctga  2940
gcagtgagc  tgctctcgg  atgcagcac  attgacctg  atgatatct  tagaaattt  3000
cagaaaaca  tttccccca  aaagcagcc  gatagatgc  ttcccaagg  ccttagttg  3060
cactttcta  gccacaaaa  agacaagag  aagtccccc  gggtcctgt  gtggaacat  3120
cggaaaacc  gctaccaaa  cgtgaagca  agctggttt  agagtttca  aatctttgt  3180
attctgctg  gcagtggag  gctgatatt  gaagatgtc  atctcccca  ccggcccca  3240
gttgagaaa  tactaaggt  taccgataa  attttcaca  ttattttcc  cctggaaat  3300
atcctgaag  gggtggcct  tggattccg  aggtatttc  ccagtgcct  gtgctggct  3360
gatttcctc  ttgtggtgg  gtctgtgct  agtctcatg  atctaccaa  cttgaagtc  3420
ttccggact  tgcgggccc  gagacctct  cgggcgctg  cccagtttg  aggaatgaa  3480
gttgtcgtc  acgccctga  cagcgccat  cctgccatt  tcaatgtct  gctggtctg  3540
ctcattttc  ggctcgtat  ttgtatctt  ggagtaaat  tattttctg  gaagtttgg  3600
aggtgcatt  acgggacag  cataaatat  tatttggat  ttaccgaag  tccgaaccg  3660
agccaatgt  acattagta  ttactcgtg  aaggtcccg  aggtcaact  tgacaacgt  3720
gggaatgcc  atctcgccc  gctgcaagt  gcaacctat  agggctggc  ggaaatcat  3780
aatgctgct  tcgattcca  agagaaaga  gagcagccg  actttgagg  gaacctcta  3840
gcgtatctc  actttgtgg  ttttatcat  ttcggctcc  tctttaccc  gaacctctt  3900
atcggtgtt  ttattgaca  cttcaatca  cagcagaaa  agttaggtg  ccaagacat  3960
tttatgaca  aagaacaga  gaaatatta  aatgcaatg  aaaagttag  aaccaagaa  4020
cctcaaaag  ccatcccaa  gcccctgaa  aaatgtcaa  cctttgtgt  cgacctggt  4080
acaagccag  tctttgacg  catcattct  ggtcttatt  tcttaaata  gattatcat  4140
atggctgaa  ctgccgacc  gcccaaaga  gtgaagaaa  cctttgata  cctcaacat  4200
gccttcgtg  tcatcttta  catagagtg  ctcatcaaa  tctttgctt  gaggcaaca  4260
tacttcacc  atggctgga  cttatttga  tgtgtggtc  tggttcttt  tatcattag  4320
accctggtt  cccgcttgg  ggacagtga  atttctttc  cgcccacgc  cttcagagt  4380
gtccgcttg  ctcggattg  tcgaatcct  aggctggtc  gggctgccc  gggaatcag  4440
accctcctc  ttgctttga  gatgtctct  ccctctctc  tcaacatcg  tctgctgct  4500
ttcctggtg  tgttcattt  cgccatctt  gggatgagc  ggttttcca  agtgaagaa  4560
ggctccggg  tcgacgaca  cttcaactt  gagaccttt  cgggcagca  gctgtgcct  4620
ttccagata  ccacttcgg  tggctggga  accctcctc  accccatgc  ggaggcaaa  4680
gaacactgc  actcctcct  ccaagacag  tgtcagcag  cgcagatag  cgtcgtcta  4740
ttcgtcagt  acatcatca  ctccttcct  atcgtggtc  acatgtaca  cgctgtgat  4800
ctcgagaac  tcaacacag  cacggagga  agcgaggac  ctctgggag  ggacgactt  4860
gaaatcttc  atgaggtct  ggagaagtt  gaccccgag  cgtcgcagt  catccagta  4920
tcggccctc  ctgactttg  ggacgccct  ccggagccg  tgcgtgtgg  caagccgaa  4980
aagtttcag  ttctagtga  ggacttgcc  atggtgatg  gcgaccgcc  ccattgcat  5040
gatgttctc  ttgctttca  taccagggt  ctcggggac  ccagcggct  ggataccat  5100
aaaaccatg  tggaggaga  gtttatgga  gccaaccct  ttaagaagc  ctacgagcc  5160
atagtcacc  ccaccaaga  gaaggagga  gagcaaggc  ccgccgtca  ccagagggc  5220
taccggaaa  acatggaga  gatggtcaa  ctgaggctg  aggacaggt  aagttcatc  5280
caccaggtg  tttgcaatg  agacttgtc  agcttggat  tggccaagg  caaggttca  5340
aatgactga  ccctcatct  cacccctac  tcactgcct  acagcttag  ctccagcct  5400
tggcgagca  gcggcagac  cactgaaca  aggccgttc  atctgtgtt  ttggctgaa  5460
gaggtgaca  gttggcgtc  atttttaaa  gactcttgg  aagatttca  gtagagaga  5520
gttagaagg  actgcaaag  acaccgacc  taacggaag  cctggagga  agtccaact  5580
acataaaga  gagaaacaa  aaggaaaga  cccaggaaa  cttcagatt  tgttctcag  5640
acattcccc  atgtgtctg  tcggtgttt  gagtatgtg  cctgccaca  gtagctctt  5700
tttgcatgt  cgtcaaaac  ctgcagtaa  ttaatagct  gctacgggt  ttcctacca  5760
catcacaga  ttgggtgta  gactcaaac  taaaagcat  actctgact  gtcagtcag  5820
accccgact  tcagacgct  caatctctg  cccaggtgt  taacgaata  ataggtaaa  5880
gaaaaaaaa  aaaaaaaaa  aaaaa  5905



<210> 909
<211> 1765
<212> PRT
<213> Rattus norvegicus
<308> AAC40199
<400> 909

Met Glu Glu Arg Tyr Tyr Pro Val Ile Phe Pro Asp Glu Arg Asn Phe 
  1               5                  10                  15
Arg Pro Phe Thr Ser Asp Ser Leu Ala Ala Ile Glu Lys Arg Ile Ala 
             20                  25                  30
Ile Gln Lys Glu Arg Lys Lys Ser Lys Asp Lys Ala Ala Ala Glu Pro 
         35                  40                  45
Gln Pro Arg Pro Gln Leu Asp Leu Lys Ala Ser Arg Lys Leu Pro Lys 
     50                  55                  60
Leu Tyr Gly Asp Ile Pro Pro Glu Leu Val Ala Lys Pro Leu Glu Asp 
 65                  70                  75                  80
Leu Asp Pro Phe Tyr Lys Asp His Lys Thr Phe Met Val Leu Asn Lys 
                 85                  90                  95
Lys Arg Thr Ile Tyr Arg Phe Ser Ala Lys Arg Ala Leu Phe Ile Leu 
             100                105                110
Gly Pro Phe Asn Pro Leu Arg Ser Leu Met Ile Arg Ile Ser Val His 
         115                120                125
Ser Val Phe Ser Met Phe Ile Ile Cys Thr Val Ile Ile Asn Cys Met 
     130                135                140
Phe Met Ala Asn Ser Met Glu Arg Ser Phe Asp Asn Asp Ile Pro Glu 
 145                150                155                160
Tyr Val Phe Ile Gly Ile Tyr Ile Leu Glu Ala Val Ile Lys Ile Leu 
                 165                170                175
Ala Arg Gly Phe Ile Val Asp Glu Phe Ser Phe Leu Arg Asp Pro Trp 
             180                185                190
Asn Trp Leu Asp Phe Ile Val Ile Gly Thr Ala Ile Ala Thr Cys Phe 
         195                200                205
Pro Gly Ser Gln Val Asn Leu Ser Ala Leu Arg Thr Phe Arg Val Phe 
     210                215                220
Arg Ala Leu Lys Ala Ile Ser Val Ile Ser Gly Leu Lys Val Ile Val 
 225                230                235                240
Gly Ala Leu Leu Arg Ser Val Lys Lys Leu Val Asp Val Met Val Leu 
                 245                250                255
Thr Leu Phe Cys Leu Ser Ile Phe Ala Leu Val Gly Gln Gln Leu Phe 
             260                265                270
Met Gly Ile Leu Asn Gln Lys Cys Ile Lys His Asn Cys Gly Pro Asn 
         275                280                285
Pro Ala Ser Asn Lys Asp Cys Phe Glu Lys Glu Lys Asp Ser Glu Asp 
     290                295                300
Phe Ile Met Cys Gly Thr Trp Leu Gly Ser Arg Pro Cys Pro Asn Gly 
 305                310                315                320
Ser Thr Cys Asp Lys Thr Thr Leu Asn Pro Asp Asn Asn Tyr Thr Lys 
                 325                330                335
Phe Asp Asn Phe Gly Trp Ser Phe Leu Ala Met Phe Arg Val Met Thr 
             340                345                350
Gln Asp Ser Trp Glu Arg Leu Tyr Arg Gln Ile Leu Arg Thr Ser Gly 
         355                360                365
Ile Tyr Phe Val Phe Phe Phe Val Val Val Ile Phe Leu Gly Ser Phe 
     370                375                380
Tyr Leu Leu Asn Leu Thr Leu Ala Val Val Thr Met Ala Tyr Glu Glu 
 385                390                395                400
Gln Asn Arg Asn Val Ala Ala Glu Thr Glu Ala Lys Glu Lys Met Phe 
                 405                410                415
Gln Glu Ala Gln Gln Leu Leu Arg Glu Glu Lys Glu Ala Leu Val Ala 
             420                425                430
Met Gly Ile Asp Arg Ser Ser Leu Asn Ser Leu Gln Ala Ser Ser Phe 
         435                440                445
Ser Pro Lys Lys Arg Lys Phe Phe Gly Ser Lys Thr Arg Lys Ser Phe 
     450                455                460
Phe Met Arg Gly Ser Lys Thr Ala Gln Ala Ser Ala Ser Asp Ser Glu 
 465                470                475                480
Asp Asp Ala Ser Lys Asn Pro Gln Leu Leu Glu Gln Thr Lys Arg Leu 
                 485                490                495
Ser Gln Asn Leu Pro Val Asp Leu Phe Asp Glu His Val Asp Pro Leu 
             500                505                510
His Arg Gln Arg Ala Leu Ser Ala Val Ser Ile Leu Thr Ile Thr Met 
         515                520                525
Gln Glu Gln Glu Lys Phe Gln Glu Pro Cys Phe Pro Cys Gly Lys Asn 
     530                535                540
Leu Ala Ser Lys Tyr Leu Val Trp Asp Cys Ser Pro Gln Trp Leu Cys 
 545                550                555                560
Ile Lys Lys Val Leu Arg Thr Ile Met Thr Asp Pro Phe Thr Glu Leu 
                 565                570                575
Ala Ile Thr Ile Cys Ile Ile Ile Asn Thr Val Phe Leu Ala Val Glu 
             580                585                590
His His Asn Met Asp Asp Asn Leu Lys Thr Ile Leu Lys Ile Gly Asn 
         595                600                605
Trp Val Phe Thr Gly Ile Phe Ile Ala Glu Met Cys Leu Lys Ile Ile 
     610                615                620
Ala Leu Asp Pro Tyr His Tyr Phe Arg His Gly Trp Asn Val Phe Asp 
 625                630                635                640
Ser Ile Val Ala Leu Leu Ser Leu Ala Asp Val Leu Tyr Asn Thr Leu 
                 645                650                655
Ser Asp Asn Asn Arg Ser Phe Leu Ala Ser Leu Arg Val Leu Arg Val 
             660                665                670
Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile 
         675                680                685
Ile Gly His Ser Val Gly Ala Leu Gly Asn Leu Thr Val Val Leu Thr 
     690                695                700
Ile Val Val Phe Ile Phe Ser Val Val Gly Met Arg Leu Phe Gly Thr 
 705                710                715                720
Lys Phe Asn Lys Thr Ala Tyr Ala Thr Gln Glu Arg Pro Arg Arg Arg 
                 725                730                735
Trp His Met Asp Asn Phe Tyr His Ser Phe Leu Val Val Phe Arg Ile 
             740                745                750
Leu Cys Gly Glu Trp Ile Glu Asn Met Trp Gly Cys Met Gln Asp Met 
         755                760                765
Asp Gly Ser Pro Leu Cys Ile Ile Val Phe Val Leu Ile Met Val Ile 
     770                775                780
Gly Lys Leu Val Val Leu Asn Leu Phe Ile Ala Leu Leu Leu Asn Ser 
 785                790                795                800
Phe Ser Asn Glu Glu Lys Asp Gly Ser Leu Glu Gly Glu Thr Arg Lys 
                 805                810                815
Thr Lys Val Gln Leu Ala Leu Asp Arg Phe Arg Arg Ala Phe Ser Phe 
             820                825                830
Met Leu His Ala Leu Gln Ser Phe Cys Cys Lys Lys Cys Arg Arg Lys 
         835                840                845
Asn Ser Pro Lys Pro Lys Glu Thr Thr Glu Ser Phe Ala Gly Glu Asn 
     850                855                860
Lys Asp Ser Ile Leu Pro Asp Ala Arg Pro Trp Lys Glu Tyr Asp Thr 
 865                870                875                880
Asp Met Ala Leu Tyr Thr Gly Gln Ala Gly Ala Pro Leu Ala Pro Leu 
                 885                890                895
Ala Glu Val Glu Asp Asp Val Glu Tyr Cys Gly Glu Gly Gly Ala Leu 
             900                905                910
Pro Thr Ser Gln His Ser Ala Gly Val Gln Ala Gly Asp Leu Pro Pro 
         915                920                925
Glu Thr Lys Gln Leu Thr Ser Pro Asp Asp Gln Gly Val Glu Met Glu 
     930                935                940
Val Phe Ser Glu Glu Asp Leu His Leu Ser Ile Gln Ser Pro Arg Lys 
 945                950                955                960
Lys Ser Asp Ala Val Ser Met Leu Ser Glu Cys Ser Thr Ile Asp Leu 
                 965                970                975
Asn Asp Ile Phe Arg Asn Leu Gln Lys Thr Val Ser Pro Lys Lys Gln 
             980                985                990
Pro Asp Arg Cys Phe Pro Lys Gly Leu Ser Cys His Phe Leu Cys His 
         995                1000                1005
Lys Thr Asp Lys Arg Lys Ser Pro Trp Val Leu Trp Trp Asn Ile Arg 
     1010                1015                1020
Lys Thr Cys Tyr Gln Ile Val Lys His Ser Trp Phe Glu Ser Phe Ile 
 1025                1030                1035                1040
Ile Phe Val Ile Leu Leu Ser Ser Gly Ala Leu Ile Phe Glu Asp Val 
                 1045                1050                1055
Asn Leu Pro Ser Arg Pro Gln Val Glu Lys Leu Leu Arg Cys Thr Asp 
             1060                1065                1070
Asn Ile Phe Thr Phe Ile Phe Leu Leu Glu Met Ile Leu Lys Trp Val 
         1075                1080                1085
Ala Phe Gly Phe Arg Arg Tyr Phe Thr Ser Ala Trp Cys Trp Leu Asp 
     1090                1095                1100
Phe Leu Ile Val Val Val Ser Val Leu Ser Leu Met Asn Leu Pro Ser 
 1105                1110                1115                1120
Leu Lys Ser Phe Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg Ala Leu 
                 1125                1130                1135
Ser Gln Phe Glu Gly Met Lys Val Val Val Tyr Ala Leu Ile Ser Ala 
             1140                1145                1150
Ile Pro Ala Ile Leu Asn Val Leu Leu Val Cys Leu Ile Phe Trp Leu 
         1155                1160                1165
Val Phe Cys Ile Leu Gly Val Asn Leu Phe Ser Gly Lys Phe Gly Arg 
     1170                1175                1180
Cys Ile Asn Gly Thr Asp Ile Asn Met Tyr Leu Asp Phe Thr Glu Val 
 1185                1190                1195                1200
Pro Asn Arg Ser Gln Cys Asn Ile Ser Asn Tyr Ser Trp Lys Val Pro 
                 1205                1210                1215
Gln Val Asn Phe Asp Asn Val Gly Asn Ala Tyr Leu Ala Leu Leu Gln 
             1220                1225                1230
Val Ala Thr Tyr Lys Gly Trp Leu Glu Ile Met Asn Ala Ala Val Asp 
         1235                1240                1245
Ser Arg Glu Lys Asp Glu Gln Pro Asp Phe Glu Ala Asn Leu Tyr Ala 
     1250                1255                1260
Tyr Leu Tyr Phe Val Val Phe Ile Ile Phe Gly Ser Phe Phe Thr Leu 
 1265                1270                1275                1280
Asn Leu Phe Ile Gly Val Ile Ile Asp Asn Phe Asn Gln Gln Gln Lys 
                 1285                1290                1295
Lys Leu Gly Gly Gln Asp Ile Phe Met Thr Glu Glu Gln Lys Lys Tyr 
             1300                1305                1310
Tyr Asn Ala Met Lys Lys Leu Gly Thr Lys Lys Pro Gln Lys Pro Ile 
         1315                1320                1325
Pro Arg Pro Leu Asn Lys Cys Gln Ala Phe Val Phe Asp Leu Val Thr 
     1330                1335                1340
Ser Gln Val Phe Asp Val Ile Ile Leu Gly Leu Ile Val Leu Asn Met 
 1345                1350                1355                1360
Ile Ile Met Met Ala Glu Ser Ala Asp Gln Pro Lys Asp Val Lys Lys 
                 1365                1370                1375
Thr Phe Asp Ile Leu Asn Ile Ala Phe Val Val Ile Phe Thr Ile Glu 
             1380                1385                1390
Cys Leu Ile Lys Val Phe Ala Leu Arg Gln His Tyr Phe Thr Asn Gly 
         1395                1400                1405
Trp Asn Leu Phe Asp Cys Val Val Val Val Leu Ser Ile Ile Ser Thr 
     1410                1415                1420
Leu Val Ser Arg Leu Glu Asp Ser Asp Ile Ser Phe Pro Pro Thr Leu 
 1425                1430                1435                1440
Phe Arg Val Val Arg Leu Ala Arg Ile Gly Arg Ile Leu Arg Leu Val 
                 1445                1450                1455
Arg Ala Ala Arg Gly Ile Arg Thr Leu Leu Phe Ala Leu Met Met Ser 
             1460                1465                1470
Leu Pro Ser Leu Phe Asn Ile Gly Leu Leu Leu Phe Leu Val Met Phe 
         1475                1480                1485
Ile Tyr Ala Ile Phe Gly Met Ser Trp Phe Ser Lys Val Lys Lys Gly 
     1490                1495                1500
Ser Gly Ile Asp Asp Ile Phe Asn Phe Glu Thr Phe Thr Gly Ser Met 
 1505                1510                1515                1520
Leu Cys Leu Phe Gln Ile Thr Thr Ser Ala Gly Trp Asp Thr Leu Leu 
                 1525                1530                1535
Asn Pro Met Leu Glu Ala Lys Glu His Cys Asn Ser Ser Ser Gln Asp 
             1540                1545                1550
Ser Cys Gln Gln Pro Gln Ile Ala Val Val Tyr Phe Val Ser Tyr Ile 
         1555                1560                1565
Ile Ile Ser Phe Leu Ile Val Val Asn Met Tyr Ile Ala Val Ile Leu 
     1570                1575                1580
Glu Asn Phe Asn Thr Ala Thr Glu Glu Ser Glu Asp Pro Leu Gly Glu 
 1585                1590                1595                1600
Asp Asp Phe Glu Ile Phe Tyr Glu Val Trp Glu Lys Phe Asp Pro Glu 
                 1605                1610                1615
Ala Ser Gln Phe Ile Gln Tyr Ser Ala Leu Ser Asp Phe Ala Asp Ala 
             1620                1625                1630
Leu Pro Glu Pro Leu Arg Val Ala Lys Pro Asn Lys Phe Gln Phe Leu 
         1635                1640                1645
Val Met Asp Leu Pro Met Val Met Gly Asp Arg Leu His Cys Met Asp 
     1650                1655                1660
Val Leu Phe Ala Phe Thr Thr Arg Val Leu Gly Asp Ser Ser Gly Leu 
 1665                1670                1675                1680
Asp Thr Met Lys Thr Met Met Glu Glu Lys Phe Met Glu Ala Asn Pro 
                 1685                1690                1695
Phe Lys Lys Leu Tyr Glu Pro Ile Val Thr Thr Thr Lys Arg Lys Glu 
             1700                1705                1710
Glu Glu Gln Gly Ala Ala Val Ile Gln Arg Ala Tyr Arg Lys His Met 
         1715                1720                1725
Glu Lys Met Val Lys Leu Arg Leu Lys Asp Arg Ser Ser Ser Ser His 
     1730                1735                1740
Gln Val Phe Cys Asn Gly Asp Leu Ser Ser Leu Asp Val Ala Lys Val 
 1745                1750                1755                1760
Lys Val His Asn Asp 
                 1765



<210> 910
<211> 5728
<212> DNA
<213> Homo sapiens
<308> AF150882
<400> 910

tcctgctat  cccacagtg  tggtcatct  ttctgatct  cacagccaa  cagctccca  60
ggcccctga  ctcagctca  cttttgtag  tccttatga  accatcctt  aagactgga  120
tcctagggc  ggctgtttt  ttcccgcct  ctgaggcct  tctgaggat  tgtggcttg  180
ctctgtcct  agggtgaag  tggatgaca  atgctaccc  gtaatcttt  cagatgagc  240
gaatttccg  cccttcact  ccgactctc  ggctgcaat  gagaagcgg  ttgccatcc  300
aaaggagaa  aagaagtct  aagaccaga  aggagaagt  ccccagcct  ggcctcagc  360
tgacctaaa  gcctccagg  agttgccca  gctctatgg  gacattcct  gtgagctca  420
aggaaagcc  ctggaagac  tggacccat  ctaccgaaa  cataagaca  ttatggtgt  480
aaacagaaa  aggacaatc  accgcttca  tgccaagca  gccttgttc  tttttgggc  540
tttcaattc  atcagaagt  tagccatta  agtctcagt  cattcattg  tcagcatgt  600
cattatcgg  accgttatc  tcaactgcg  gttcatggc  acagggcct  ctaaaaaca  660
caacagtaa  aatactgac  ttgcagagt  tgtcttcac  gggatttat  tttttgaag  720
tttgattaa  atattggca  gaggtttca  tctggatga  ttttctttc  ttcgagatc  780
atggaactg  ctggactcc  ttgtcattg  aatagcgat  gtgtcatat  ttccaggaa  840
caccatcaa  ctattgccc  tgcgtacct  ccgtgtgtt  agagctttg  aagcaattt  900
agtagtttc  cgtctgaag  tcatcgtgg  ggccttgct  cgctctgtg  agaagctgg  960
caacgtgat  atcctcacc  tcttttgcc  cagcatctt  gccctggta  gtcagcagc  1020
cttcatggg  agtctgaac  tgaaatgca  ctcgaggga  tgtaaaaat  tcagtaacc  1080
ggaagctta  gaccattgc  ttgaaaaga  agaaaattc  cctgaattc  aaatgtgtg  1140
catctggat  ggtaacagt  cctgttcca  acaatatga  tgtaagcac  ccaaaatta  1200
tcctgacta  aattatacg  attttgaca  ctttggctg  tcttttctt  ccatgttcc  1260
gctgatgac  caagattcc  gggagaagc  ttatcaaca  accctgcgt  ctactgggc  1320
ctactcagt  ttcttcttc  ttgtggtca  tttcctggg  tccttctac  tgattaact  1380
aaccctggc  gttgttacc  tggcatatg  ggagcagaa  aagaatgta  ctgcagaga  1440
agaggccaa  gaaaagatg  ttcaggaag  ccagcagct  ttaaaggag  aaaaggagg  1500
tctggttgc  atgggaatt  acagaagtt  acttacttc  cttgaaaca  catatttta  1560
cccaaaaaa  agaaagctc  ttggtaata  gaaaaggaa  tccttcttt  tgagagagt  1620
tgggaaaga  cagcctcct  ggtcagatt  tgatgaaga  tgccaaaaa  agccacagc  1680
cctagagca  accaaacga  tgtcccaga  tctatcact  gaccacttt  atgagcatg  1740
agatcctct  caaaggcag  gagcactga  tgccgtcag  atcctcacc  tcaccatga  1800
ggaacaaga  aaatcacaa  agccttgtc  cccttgcgg  gaaaacctg  catccaagt  1860
cctcgtgtg  aactgttgc  cccagtggc  gtgcgttaa  aaggtcctg  gaactgtga  1920
gactgaccc  tttactgag  tggccatca  catctgcat  atcatcaac  ctgtcttct  1980
ggccatgga  catcacaag  tggaggcca  ttttgagaa  atgttgaat  tagggaatt  2040
ggttttcac  agcattttt  tagcagaaa  gtgcctaaa  atcattgcg  tcgatccct  2100
ccactactt  cgccgaggc  ggaacattt  tgacagcat  gttgctctt  tgagttttg  2160
agatgtaat  aactgtgta  ttcaaaaga  aagctggcc  ttcttgcgt  ccttcaggg  2220
gctcagggt  ttcaagtta  ccaaatcct  gccaacttt  aacacacta  ttaagataa  2280
cggcaactc  gtcggagcc  ttggaaacc  gactgtggt  ctggtcatt  tgatcttta  2340
tttctcagt  gttggcatg  agctttttg  ccgtagctt  aattcccaa  agagtccaa  2400
actctgtaa  ccgacaggc  cgacagtct  atgtttacg  cactggcac  tgggggatt  2460
ctggcactc  ttcctagtg  tattccgca  cctctgcgg  gaatggatc  aaaatatgt  2520
ggaatgtat  caagaagcg  atgcatcat  atcattgtg  gttattgtc  tcatattga  2580
cacggtgat  ggaaaactt  tggtgctca  cctcttcat  gccttactg  tcaattcct  2640
tagcaatga  gaaagaaat  gaaacttag  aggagaggc  aggaaaact  aagtccagt  2700
agcactgga  cgattccgc  gggcttttt  ttttgtgag  cacactctt  agcatttct  2760
tcacaagtg  tgcaggaag  aaaacttac  acagcaaaa  gaggtggca  gaggctgtg  2820
tgcacaaag  aaagacatc  ttcccctgg  catggagat  aaaaggggc  cagagaccc  2880
ggaggagct  ggtatacta  cctctgtac  aaagaccct  ggcgtcagg  atgattgga  2940
ttggttggc  ccacttgcg  aggaggaag  tgacgttga  ttttctggt  aagataatg  3000
acagcgcat  acacaacct  agcctgaac  acaggccta  gagctccat  aggagaaca  3060
gaagcccac  agccagaga  ttcaaagtg  ggaaattga  atgttctct  aagatgagc  3120
tcatctgac  atacaggat  cccgaaaga  gtctgatgt  accagtata  tatcagaat  3180
tagcaccat  gatcttcag  atggctttg  atggttacc  gagatggtt  ccaaaaagc  3240
accagagag  tgtttgccc  aaggctttg  ttgctgctt  ccatgctgt  gcgtggaca  3300
gagaaagcc  ccctgggtc  tttggtgga  cctgcggaa  acctgctac  aaatagtga  3360
acacagctg  tttgagagc  ttattatct  tgtgattct  ctgagcagt  gggcactga  3420
atttgaaga  gttcacctt  agaaccaac  caaaatcca  gaattacta  attgtactg  3480
cattatttt  acacatatt  ttatcctgg  gatggtact  aaatgggta  ccttcggat  3540
tggaaagta  ttcaccagt  cctggtgct  ccttgattt  atcattgtg  ttgtctctg  3600
gaccaccct  attaactta  tggaattga  gtccttccg  actctacga  cactgaggc  3660
tcttcgtgc  ctgtcccag  ttgaaggaa  gaaggtggt  gtcaatgct  tcataggtg  3720
catacctgc  attctgaat  ttttgcttg  ctgcctcat  ttctggctc  tattttgta  3780
tctgggagt  tacttcttt  ctggaaaat  tgggaaatg  attaatgga  cagactcag  3840
tataaatta  accatcatt  caaataaaa  tcaatgtga  agtggcaat  tctcttgga  3900
caaccagaa  gtcaacttt  acaatgtgg  aaatgctta  ctcgctctg  tgcaagtgg  3960
aacatttaa  ggctggatg  atattatat  tgcagctgt  gattccaca  agaaagaac  4020
acagccaga  tttgagagc  attcactcg  ttacattta  ttcgtagtc  ttatcatct  4080
tggctcatt  ttcactctg  atctcttca  tggcgttat  attgacaac  tcaaccaac  4140
gcagaaaaa  ttaggtggc  aagacattt  tatgacaga  gaacagaag  aatactata  4200
tgcaatgaa  aaattagga  ccaaaaaac  tcaaaaacc  attccacgg  ctctgaaca  4260
atgtcaagg  ctcgtgttc  acatagtca  aagccagat  tttgacatc  tcatcataa  4320
tctcattat  ctaaacatg  ttagcatga  ggctgaatc  tacaaccaa  ccaaagcca  4380
gaaatccat  cttgaccat  tcaactggg  ctttgtggt  atctttacg  tagaatgtc  4440
catcaaaat  tttgctttg  ggcaatact  cttcaccaa  ggctggaat  tatttgact  4500
tgtggtcgt  cttctttcc  ttgttagta  gtaaaatca  cagtcagag  gactttaag  4560
accagaagt  agtttgtaa  tcttatcat  ttttgaagt  tgttcaaac  atccacaaa  4620
cagaaaact  ggccaagtg  actttctga  agaatagac  ggggtacta  tgccattct  4680
tactgggaa  ttgctagga  atagagagt  atttctgtt  ccttaactc  ctacacaac  4740
gaaatagag  tcaataatc  tgcagctaa  gtattcaat  gaaatagac  aaattaaaa  4800
gactcagaa  tttttgtgg  ggtaacctg  tttattcag  taattgagt  aaagttcta  4860
ctttcctgc  caactataa  ctctatgag  attttttag  tttaaggat  tactgccca  4920
gttttttcc  ttgttcaaa  tccacatgg  tgccagatc  caattattg  gcccctgtg  4980
cactgctgt  ccccctttc  acccctata  aaggcccca  ggcccactc  agattgggc  5040
ttcaagagt  tatcattca  acaatcaaa  ctttttttc  attctatat  ccatgttaa  5100
ttaaaccac  gtgtgaact  tgcttgtct  agattcttt  accccgctt  ccaaccagc  5160
tcattctct  atcagtata  ttttcctaa  cacacgcag  gttaactaa  aggcttata  5220
aagaataca  aagaaagga  gttattacc  tactccttc  ttataaaac  cacatacac  5280
catcaactt  aaaattaaa  tcttcatgg  taagccata  gtgcttact  tgggttttt  5340
aagtctggt  ttaattaaa  tgttaactt  acattttat  attatgtaa  actgtccag  5400
agcccttct  atagttcaa  acacaatga  gacaaagaa  actgatttt  caaatggaa  5460
cttttttgc  atctcagaa  gaatgcatc  aacagatat  ttggatcaa  atattttgg  5520
tcctaatgc  actgcagca  tgcagatgt  tcagagaac  acaacaaat  tgctacagt  5580
catagtgtg  tctggtttc  aagctatga  gttaatgta  ataaagctt  tnaatagat  5640
cttccatga  tttacagtt  agtagacct  taattttta  tattcaatt  caatcacaa  5700
tcttggtga  attgacagc  ggaaaaaa  5728



<210> 911
<211> 2016
<212> PRT
<213> Homo sapiens
<308> NP_000326
<400> 911

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
  1               5                  10                  15
Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
             20                  25                  30
Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
         35                  40                  45
Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
     50                  55                  60
Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
 65                  70                  75                  80
Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                 85                  90                  95
Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
             100                105                110
Val Leu Ser Pro Phe His Pro Val Arg Arg Ala Ala Val Lys Ile Leu 
         115                120                125
Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
     130                135                140
Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
 145                150                155                160
Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                 165                170                175
Leu Ala Arg Ala Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
             180                185                190
Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
         195                200                205
Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
     210                215                220
Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
 225                230                235                240
Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                 245                250                255
Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
             260                265                270
Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
         275                280                285
Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
     290                295                300
Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
 305                310                315                320
Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                 325                330                335
Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
             340                345                350
Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
         355                360                365
Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
     370                375                380
Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
 385                390                395                400
Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                 405                410                415
Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
             420                425                430
Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
         435                440                445
Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
     450                455                460
Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
 465                470                475                480
Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                 485                490                495
Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
             500                505                510
Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
         515                520                525
Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
     530                535                540
Asp Asp Glu Asn Ser Thr Ala Arg Glu Ser Glu Ser His His Thr Ser 
 545                550                555                560
Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                 565                570                575
Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
             580                585                590
Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
         595                600                605
Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
     610                615                620
Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
 625                630                635                640
Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                 645                650                655
Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
             660                665                670
Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
         675                680                685
Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
     690                695                700
Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
 705                710                715                720
Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                 725                730                735
Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
             740                745                750
Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
         755                760                765
Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
     770                775                780
Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
 785                790                795                800
Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                 805                810                815
Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
             820                825                830
Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
         835                840                845
Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
     850                855                860
Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
 865                870                875                880
Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                 885                890                895
Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
             900                905                910
Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
         915                920                925
Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
     930                935                940
Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
 945                950                955                960
Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                 965                970                975
Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg His Arg Pro Gln Lys Pro 
             980                985                990
Ala Ala Leu Ala Ala Gln Gly Gln Leu Pro Ser Cys Ile Ala Thr Pro 
         995                1000                1005
Tyr Ser Pro Pro Pro Pro Glu Thr Glu Lys Val Pro Pro Thr Arg Lys 
     1010                1015                1020
Glu Thr Gln Phe Glu Glu Gly Glu Gln Pro Gly Gln Gly Thr Pro Gly 
 1025                1030                1035                1040
Asp Pro Glu Pro Val Cys Val Pro Ile Ala Val Ala Glu Ser Asp Thr 
                 1045                1050                1055
Asp Asp Gln Glu Glu Asp Glu Glu Asn Ser Leu Gly Thr Glu Glu Glu 
             1060                1065                1070
Ser Ser Lys Gln Gln Glu Ser Gln Pro Val Ser Gly Trp Pro Arg Gly 
         1075                1080                1085
Pro Pro Asp Ser Arg Thr Trp Ser Gln Val Ser Ala Thr Ala Ser Ser 
     1090                1095                1100
Glu Ala Glu Ala Ser Ala Ser Gln Ala Asp Trp Arg Gln Gln Trp Lys 
 1105                1110                1115                1120
Ala Glu Pro Gln Ala Pro Gly Cys Gly Glu Thr Pro Glu Asp Ser Cys 
                 1125                1130                1135
Ser Glu Gly Ser Thr Ala Asp Met Thr Asn Thr Ala Glu Leu Leu Glu 
             1140                1145                1150
Gln Ile Pro Asp Leu Gly Gln Asp Val Lys Asp Pro Glu Asp Cys Phe 
         1155                1160                1165
Thr Glu Gly Cys Val Arg Arg Cys Pro Cys Cys Ala Val Asp Thr Thr 
     1170                1175                1180
Gln Ala Pro Gly Lys Val Trp Trp Arg Leu Arg Lys Thr Cys Tyr His 
 1185                1190                1195                1200
Ile Val Glu His Ser Trp Phe Glu Thr Phe Ile Ile Phe Met Ile Leu 
                 1205                1210                1215
Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Leu Glu Glu Arg 
             1220                1225                1230
Lys Thr Ile Lys Val Leu Leu Glu Tyr Ala Asp Lys Met Phe Thr Tyr 
         1235                1240                1245
Val Phe Val Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Phe Lys 
     1250                1255                1260
Lys Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile Val Asp 
 1265                1270                1275                1280
Val Ser Leu Val Ser Leu Val Ala Asn Thr Leu Gly Phe Ala Glu Met 
                 1285                1290                1295
Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg 
             1300                1305                1310
Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala Leu Val 
         1315                1320                1325
Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile Phe 
     1330                1335                1340
Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys Phe 
 1345                1350                1355                1360
Gly Arg Cys Ile Asn Gln Thr Glu Gly Asp Leu Pro Leu Asn Tyr Thr 
                 1365                1370                1375
Ile Val Asn Asn Lys Ser Gln Cys Glu Ser Leu Asn Leu Thr Gly Glu 
             1380                1385                1390
Leu Tyr Trp Thr Lys Val Lys Val Asn Phe Asp Asn Val Gly Ala Gly 
         1395                1400                1405
Tyr Leu Ala Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp Ile 
     1410                1415                1420
Met Tyr Ala Ala Val Asp Ser Arg Gly Tyr Glu Glu Gln Pro Gln Trp 
 1425                1430                1435                1440
Glu Tyr Asn Leu Tyr Met Tyr Ile Tyr Phe Val Ile Phe Ile Ile Phe 
                 1445                1450                1455
Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp Asn 
             1460                1465                1470
Phe Asn Gln Gln Lys Lys Lys Leu Gly Gly Gln Asp Ile Phe Met Thr 
         1475                1480                1485
Glu Glu Gln Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser Lys 
     1490                1495                1500
Lys Pro Gln Lys Pro Ile Pro Arg Pro Leu Asn Lys Tyr Gln Gly Phe 
 1505                1510                1515                1520
Ile Phe Asp Ile Val Thr Lys Gln Ala Phe Asp Val Thr Ile Met Phe 
                 1525                1530                1535
Leu Ile Cys Leu Asn Met Val Thr Met Met Val Glu Thr Asp Asp Gln 
             1540                1545                1550
Ser Pro Glu Lys Ile Asn Ile Leu Ala Lys Ile Asn Leu Leu Phe Val 
         1555                1560                1565
Ala Ile Phe Thr Gly Glu Cys Ile Val Lys Leu Ala Ala Leu Arg His 
     1570                1575                1580
Tyr Tyr Phe Thr Asn Ser Trp Asn Ile Phe Asp Phe Val Val Val Ile 
 1585                1590                1595                1600
Leu Ser Ile Val Gly Thr Val Leu Ser Asp Ile Ile Gln Lys Tyr Phe 
                 1605                1610                1615
Phe Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly Arg 
             1620                1625                1630
Ile Leu Arg Leu Ile Arg Gly Ala Lys Gly Ile Arg Thr Leu Leu Phe 
         1635                1640                1645
Ala Leu Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu Leu 
     1650                1655                1660
Phe Leu Val Met Phe Ile Tyr Ser Ile Phe Gly Met Ala Asn Phe Ala 
 1665                1670                1675                1680
Tyr Val Lys Trp Glu Ala Gly Ile Asp Asp Met Phe Asn Phe Gln Thr 
                 1685                1690                1695
Phe Ala Asn Ser Met Leu Cys Leu Phe Gln Ile Thr Thr Ser Ala Gly 
             1700                1705                1710
Trp Asp Gly Leu Leu Ser Pro Ile Leu Asn Thr Gly Pro Pro Tyr Cys 
         1715                1720                1725
Asp Pro Thr Leu Pro Asn Ser Asn Gly Ser Arg Gly Asp Cys Gly Ser 
     1730                1735                1740
Pro Ala Val Gly Ile Leu Phe Phe Thr Thr Tyr Ile Ile Ile Ser Phe 
 1745                1750                1755                1760
Leu Ile Val Val Asn Met Tyr Ile Ala Ile Ile Leu Glu Asn Phe Ser 
                 1765                1770                1775
Val Ala Thr Glu Glu Ser Thr Glu Pro Leu Ser Glu Asp Asp Phe Asp 
             1780                1785                1790
Met Phe Tyr Glu Ile Trp Glu Lys Phe Asp Pro Glu Ala Thr Gln Phe 
         1795                1800                1805
Ile Glu Tyr Ser Val Leu Ser Asp Phe Ala Asp Ala Leu Ser Glu Pro 
     1810                1815                1820
Leu Arg Ile Ala Lys Pro Asn Gln Ile Ser Leu Ile Asn Met Asp Leu 
 1825                1830                1835                1840
Pro Met Val Ser Gly Asp Arg Ile His Cys Met Asp Ile Leu Phe Ala 
                 1845                1850                1855
Phe Thr Lys Arg Val Leu Gly Glu Ser Gly Glu Met Asp Ala Leu Lys 
             1860                1865                1870
Ile Gln Met Glu Glu Lys Phe Met Ala Ala Asn Pro Ser Lys Ile Ser 
         1875                1880                1885
Tyr Glu Pro Ile Thr Thr Thr Leu Arg Arg Lys His Glu Glu Val Ser 
     1890                1895                1900
Ala Met Val Ile Gln Arg Ala Phe Arg Arg His Leu Leu Gln Arg Ser 
 1905                1910                1915                1920
Leu Lys His Ala Ser Phe Leu Phe Arg Gln Gln Ala Gly Ser Gly Leu 
                 1925                1930                1935
Ser Glu Glu Asp Ala Pro Glu Arg Glu Gly Leu Ile Ala Tyr Val Met 
             1940                1945                1950
Ser Glu Asn Phe Ser Arg Pro Leu Gly Pro Pro Ser Ser Ser Ser Ile 
         1955                1960                1965
Ser Ser Thr Ser Phe Pro Pro Ser Tyr Asp Ser Val Thr Arg Ala Thr 
     1970                1975                1980
Ser Asp Asn Leu Gln Val Arg Gly Ser Asp Tyr Ser His Ser Glu Asp 
 1985                1990                1995                2000
Leu Ala Asp Phe Pro Pro Ser Pro Asp Arg Asp Arg Glu Ser Ile Val 
                 2005                2010                2015



<210> 912
<211> 632
<212> DNA
<213> Rattus norvegicus
<308> AF061242
<400> 912

gcagcaact  agaaacttg  gagactttc  gttggtcta  aatcggatg  cagaactgt  60
cttccagcg  tgtgtgccc  gcctgcacc  ccgagctct  gacgctgag  aggaggcct  120
cctgcacag  tgtgctggg  agctcatcc  ttctaacca  cgcctcatg  ccgcttacg  180
gcacctcat  cccgccctg  tccagcgcc  catggcgga  tacgaggct  cctctgccg  240
gccaggtgt  cctgcagaa  agcccagag  ctcgccatc  ggcagctag  tagctgtcc  300
tgaccgcag  agagaaggt  gttttgctg  gggcacatt  gtcttcaat  cgatcctcc  360
gtctcagcc  cccaggtac  ggaattaca  acatgggct  caactggtt  ctagataat  420
ctttaggaa  ataaaaatt  ctgaccaga  gcttcccta  agagtgacc  gtgtacatg  480
ttaatttca  tccttgaca  gtacaaacg  gagtagagc  gcttgtgaa  ttaattccc  540
aaaccagga  ggtggagac  caggatatt  tgtgactgc  gaagagctc  aatcagcat  600
tgtatgtat  ccttcaata  acatgtgct  tg  632



<210> 913
<211> 100
<212> PRT
<213> Rattus norvegicus
<308> Q9R1B1
<400> 913

Met Glu His Gln Gln Gln Gln Leu Arg Asn Leu Arg Asp Phe Leu Leu 
  1               5                  10                  15
Val Tyr Asn Arg Met Thr Glu Leu Cys Phe Gln Arg Cys Val Pro Ser 
             20                  25                  30
Leu His His Arg Ala Leu Asp Ala Glu Glu Glu Ala Cys Leu His Ser 
         35                  40                  45
Cys Ala Gly Lys Leu Ile His Ser Asn His Arg Leu Met Ala Ala Tyr 
     50                  55                  60
Val His Leu Met Pro Ala Leu Val Gln Arg Arg Met Ala Asp Tyr Glu 
 65                  70                  75                  80
Ala Ala Ser Ala Val Pro Gly Val Pro Ala Glu Gln Pro Arg Asp Ser 
                 85                  90                  95
Pro Ser Gly Ser 
             100



<210> 914
<211> 421
<212> DNA
<213> Homo sapiens
<308> AI005112
<400> 914

tgtttaaag  ctttattgc  aatttcaca  aggcaggaa  tactaagag  gtaaattgg  60
gaaatggtc  acattcctg  attcttaga  gcttgtctt  gttctgttg  cactgacct  120
ctaggaagc  gtggctaaa  cctaagggg  tagagtttt  ttcctgctt  tgttgtttg  180
ttttacctt  ttcccctag  ttcacagca  ttctttttg  cagcttctc  ccaggggcc  240
gggacggct  gctgcctga  ggcgagtct  tggtctgtt  tgcaggaat  cctggcgcg  300
ccgaggcag  ctcgtagtc  gcgatgcgg  gctggacca  ggcgggcat  aggtgcacg  360
aagcggcca  gaggcggtg  ttagaatgg  tgagtttcc  agcacagct  tgcaggcag  420
c  421



<210> 915
<211> 103
<212> PRT
<213> Homo sapiens
<308> Q9Y5J6
<400> 915

Met Glu Arg Gln Gln Gln Gln Gln Gln Gln Leu Arg Asn Leu Arg Asp 
  1               5                  10                  15
Phe Leu Leu Val Tyr Asn Arg Met Thr Glu Leu Cys Phe Gln Arg Cys 
             20                  25                  30
Val Pro Ser Leu His His Arg Ala Leu Asp Ala Glu Glu Glu Ala Cys 
         35                  40                  45
Leu His Ser Cys Ala Gly Lys Leu Ile His Ser Asn His Arg Leu Met 
     50                  55                  60
Ala Ala Tyr Val Gln Leu Met Pro Ala Leu Val Gln Arg Arg Ile Ala 
 65                  70                  75                  80
Asp Tyr Glu Ala Ala Ser Ala Val Pro Gly Val Ala Ala Glu Gln Pro 
                 85                  90                  95
Gly Val Ser Pro Ser Gly Ser 
             100



<210> 916
<211> 4069
<212> DNA
<213> Rattus norvegicus
<308> AF061266
<400> 916

ggcttccat  ctaatacga  tcactatag  gctcgagcg  ccgcccggg  aggtctgcc  60
ccgtcctgg  ccgcgatga  ggcggccct  tacccgagc  cggacctct  tggcgtctc  120
tcctcctcc  tgccttcct  cccatcctc  tcatcgccc  acgaagtga  ggcgctgaa  180
gatgtgcga  aggtgaagg  ggagaacac  ttgaatgag  agcttttct  gctggcgtg  240
gacaagggt  actattata  ggttaaaaa  attttggag  aaaacagtt  aggtgactt  300
aacataaat  gcgtagatg  gcttgggag  aatgctgtt  ccataacta  tgaaaacga  360
agcttggat  tactgcagc  gcttttgga  tacggttgt  agaaactta  ggaacgaat  420
cagaatccg  aatactcaa  aacaatgga  gttgcacca  ttattttag  tgctcatcg  480
aacaactat  agatcctca  aatgcttct  aagcaggac  tggctttgc  caagcccca  540
gctgttggc  gtgaatgca  gctgtgttc  gcgaaaaac  aaaaggaca  cctcagaca  600
tccaggttt  gtcttgata  ctatagatg  ctggccagt  cagctctaa  aatgttaac  660
gaggaggat  caattctga  agcgtttga  cttagtgct  acttaaagg  actcagcct  720
gtggaggtg  aattctgga  tgactatga  gagctagcc  gtcagtgca  aatgtttgc  780
aaagatttg  ttgcgcaag  tcggaattc  cgtgaactg  aagttatcc  aaaccatac  840
tctagtgat  agcctcttg  caaacgagg  ctactagaa  aaagaatga  tttaagtcg  900
ctgaaactt  ctatcaaat  taaccagaa  gagtttgtc  cccagtcaa  ttgccagca  960
ttcctgaac  ccgtttggt  cggacagat  tcaggttac  gccgtaagc  cacctgtaa  1020
aagataatg  ctgttttga  agttggcat  ttctggcca  ttctgtcac  gtgttactt  1080
atagctccc  aatctcaat  cggcagaat  attcacaca  cgttcatga  gtttattat  1140
catggagct  catatttca  attcttgct  ttactcaat  tctactcac  tgtctacaa  1200
gaggacaag  aaaatacaa  ggggccagc  cttgagaga  tagactacc  tctcatact  1260
tggattatt  ggatgattt  gtcagacat  aagaggctg  ggtatgaag  gttggaaga  1320
ttcttagaa  aatctcgta  ccagctcag  tttgttatg  attcccttt  cttggcaac  1380
tttgccctc  aagtggtgg  tcacaacaa  tttcatgat  ttgccgacc  gaaggactg  1440
gatgcgttc  accccacac  ggtagcaga  gggcttttc  cctttgcaa  cgttctgag  1500
taccttcgg  tcttcttta  gtacacaac  agctctatt  tgggcccac  gcagatttc  1560
atgggacag  tgttacaag  ttttgggaa  tttctagga  tgttccttc  tgttctgtt  1620
tccttcacg  ttggactga  acagctcta  gacaaaggg  acacttcca  agagcagaa  1680
gactgcgta  gcatcttct  tgaacagca  agcaacgac  ccttccact  gttcattgg  1740
acctgcttt  ctctgttct  gtacatctt  tccttagcg  atgtggcca  ctttgtcac  1800
aggtttagc  atggggaag  actgcagtc  ttcgttggg  ctgtgattg  cggaactta  1860
aatgtcgtg  ttgtgatcg  gcttacaaa  ctactggta  cgatgcttc  taagagctt  1920
cagctgata  caaatcatg  ggataaaga  tggaagttt  ctcgagcga  gctatggct  1980
agctacttt  atgacaaat  cacactgcc  ccacctttc  acatcattc  ttctccgaa  2040
actatctgc  atatgatca  cagcctcag  aagtgggtg  gctcgcaca  ctccaaagg  2100
aaggtcaga  ggcagaaca  cttgaagga  tggagaaac  taaaacaaa  gagagatga  2160
aactaccag  aggtgatgt  ctgcctagt  catcgatac  tgacctcca  gcgacagaa  2220
atgcagagc  cagaccaag  caccgtgga  aatctcaat  aactgcgcc  agatctgtc  2280
aaattccga  atgaaataa  ggatttgct  ggctttcgg  cttctaaat  tgctatgtt  2340
tatcccaaa  attagccat  ttctaaatc  tgtagaaat  attttcttt  ataaatctg  2400
aagactgta  ttgcatacc  ttcaattaa  tcaataaga  atatatggg  ataaacaat  2460
acacagaag  cattcttta  atatttata  cataaacat  tgttgtgta  atatgtata  2520
agagctagt  ttttaaaac  tgtctgtga  tttttgtag  agcaaaacc  ttttgttag  2580
atgctactt  gttttctta  ttggtcagt  cttacattc  acgtgtgta  gaggggcag  2640
tctcagtgt  cgcatggcc  actccattt  tacgcgaag  tcagcaaac  cggctacct  2700
aagacacac  tgaagagct  atgctgttg  aatctcttg  tttaggagt  cacacagag  2760
tcagtatat  ttgtttagg  gtttagctt  atctaaaat  ccctacttt  tcttttgtt  2820
gaatcttaa  cagcagaga  aagtttata  taaatattt  aatttaacc  agtcatggt  2880
atgaatgcc  ttaatccca  cactcggga  gcagaggca  gcagatctc  gagttcaag  2940
tcagcctgg  ctacagagt  ggttccagg  tagccccgg  tacacagag  aaccctgtc  3000
tggaaaaat  aaaaacaac  aaaaaaaat  taaattatt  atttatgtc  atctaaatt  3060
acgttggta  ttgttgtgt  gtatattta  ttttacatg  ttataattt  tatttttaa  3120
tttgttttg  cataacatt  ttttatata  atttcccta  attaaggta  tttatatgt  3180
taaatattt  tagacgtct  tgaattttg  aaaatagta  ccatctttt  cccatagaa  3240
acttgtttc  atttatacc  tcgcagagg  acctcttaa  catttggct  agtttagct  3300
ttccttcca  tttttcaag  tggagtaaa  ctcatcgtt  caaagtaga  gctgcttat  3360
ttcatgtgc  gtcacagtg  gcttggccg  agagcactg  gccttgctt  cagaaggct  3420
ctttccgtt  actccaagg  tcttgagct  ctcttccaa  gtttctccc  cagagccta  3480
cacagcttc  acaaaactg  cctcgtgct  gcggcttga  atgtaaagc  ttgtttatt  3540
aatttgaaa  taaaaagaa  ttgactgct  ttcagtgtt  atgtaaagg  ggagctgaa  3600
gtttcccca  ctatggcac  gacattcct  cagcacgtt  ggtgagaaa  taccttcgg  3660
actgaacgt  agctggcat  gaggccaca  agtgcagac  gccctggtc  gtgagcgcc  3720
cccaccccg  ggcagctga  gatcccagt  taggtttca  cttgctttt  gcatttgtt  3780
ttaatgtcc  aggtttaag  gttccctct  ttgggcaaa  tcttataaa  atgtttatt  3840
taaaattat  tattttgtc  acaatggga  tatgcgctt  caagttgat  ttttacatc  3900
ggattttta  tcattctaa  aaaaatacc  aattattaa  aaatttata  agtacctat  3960
tgtgcatga  ttactgacg  ggtatattt  gaatgacag  atattgtaa  aaaagagtg  4020
ataaaattt  gcattagat  ataaaaaaa  aaaaaaaaa  aaaaaaaaa  4069



<210> 917
<211> 759
<212> PRT
<213> Rattus norvegicus
<308> Q9QX01
<400> 917

Met Met Ala Ala Leu Tyr Pro Ser Thr Asp Leu Ser Gly Val Ser Ser 
  1               5                  10                  15
Ser Ser Leu Pro Ser Ser Pro Ser Ser Ser Ser Pro Asn Glu Val Met 
             20                  25                  30
Ala Leu Lys Asp Val Arg Glu Val Lys Glu Glu Asn Thr Leu Asn Glu 
         35                  40                  45
Lys Leu Phe Leu Leu Ala Cys Asp Lys Gly Asp Tyr Tyr Met Val Lys 
     50                  55                  60
Lys Ile Leu Glu Glu Asn Ser Ser Gly Asp Leu Asn Ile Asn Cys Val 
 65                  70                  75                  80
Asp Val Leu Gly Arg Asn Ala Val Thr Ile Thr Ile Glu Asn Glu Ser 
                 85                  90                  95
Leu Asp Ile Leu Gln Leu Leu Leu Asp Tyr Gly Cys Gln Lys Leu Met 
             100                105                110
Glu Arg Ile Gln Asn Pro Glu Tyr Ser Thr Thr Met Asp Val Ala Pro 
         115                120                125
Val Ile Leu Ala Ala His Arg Asn Asn Tyr Glu Ile Leu Thr Met Leu 
     130                135                140
Leu Lys Gln Asp Val Ala Leu Pro Lys Pro His Ala Val Gly Cys Glu 
 145                150                155                160
Cys Thr Leu Cys Ser Ala Lys Asn Lys Lys Asp Ser Leu Arg His Ser 
                 165                170                175
Arg Phe Arg Leu Asp Ile Tyr Arg Cys Leu Ala Ser Pro Ala Leu Ile 
             180                185                190
Met Leu Thr Glu Glu Asp Pro Ile Leu Arg Ala Phe Glu Leu Ser Ala 
         195                200                205
Asp Leu Lys Glu Leu Ser Leu Val Glu Val Glu Phe Trp Asn Asp Tyr 
     210                215                220
Glu Glu Leu Ala Arg Gln Cys Lys Met Phe Ala Lys Asp Leu Leu Ala 
 225                230                235                240
Gln Ala Arg Asn Ser Arg Glu Leu Glu Val Ile Leu Asn His Thr Ser 
                 245                250                255
Ser Asp Glu Pro Leu Asp Lys Arg Gly Leu Leu Glu Glu Arg Met Asn 
             260                265                270
Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Asn Gln Lys Glu Phe Val 
         275                280                285
Ser Gln Ser Asn Cys Gln Gln Phe Leu Asn Thr Val Trp Phe Gly Gln 
     290                295                300
Met Ser Gly Tyr Arg Arg Lys Pro Thr Cys Lys Lys Ile Met Thr Val 
 305                310                315                320
Leu Thr Val Gly Ile Phe Trp Pro Val Leu Ser Leu Cys Tyr Leu Ile 
                 325                330                335
Ala Pro Lys Ser Gln Phe Gly Arg Ile Ile His Thr Pro Phe Met Lys 
             340                345                350
Phe Ile Ile His Gly Ala Ser Tyr Phe Thr Phe Leu Leu Leu Leu Asn 
         355                360                365
Leu Tyr Ser Leu Val Tyr Asn Glu Asp Lys Lys Asn Thr Met Gly Pro 
     370                375                380
Ala Leu Glu Arg Ile Asp Tyr Leu Leu Ile Leu Trp Ile Ile Gly Met 
 385                390                395                400
Ile Trp Ser Asp Ile Lys Arg Leu Trp Tyr Glu Gly Leu Glu Asp Phe 
                 405                410                415
Leu Glu Glu Ser Arg Asn Gln Leu Ser Phe Val Met Asn Ser Leu Tyr 
             420                425                430
Leu Ala Thr Phe Ala Leu Lys Val Val Ala His Asn Lys Phe His Asp 
         435                440                445
Phe Ala Asp Arg Lys Asp Trp Asp Ala Phe His Pro Thr Leu Val Ala 
     450                455                460
Glu Gly Leu Phe Ala Phe Ala Asn Val Leu Ser Tyr Leu Arg Leu Phe 
 465                470                475                480
Phe Met Tyr Thr Thr Ser Ser Ile Leu Gly Pro Leu Gln Ile Ser Met 
                 485                490                495
Gly Gln Met Leu Gln Asp Phe Gly Lys Phe Leu Gly Met Phe Leu Leu 
             500                505                510
Val Leu Phe Ser Phe Thr Ile Gly Leu Thr Gln Leu Tyr Asp Lys Gly 
         515                520                525
Tyr Thr Ser Lys Glu Gln Lys Asp Cys Val Gly Ile Phe Cys Glu Gln 
     530                535                540
Gln Ser Asn Asp Thr Phe His Ser Phe Ile Gly Thr Cys Phe Ala Leu 
 545                550                555                560
Phe Trp Tyr Ile Phe Ser Leu Ala His Val Ala Ile Phe Val Thr Arg 
                 565                570                575
Phe Ser Tyr Gly Glu Glu Leu Gln Ser Phe Val Gly Ala Val Ile Val 
             580                585                590
Gly Thr Tyr Asn Val Val Val Val Ile Val Leu Thr Lys Leu Leu Val 
         595                600                605
Ala Met Leu His Lys Ser Phe Gln Leu Ile Ala Asn His Glu Asp Lys 
     610                615                620
Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe Asp Asp 
 625                630                635                640
Lys Cys Thr Leu Pro Pro Pro Phe Asn Ile Ile Pro Ser Pro Lys Thr 
                 645                650                655
Ile Cys Tyr Met Ile Ser Ser Leu Ser Lys Trp Val Cys Ser His Thr 
             660                665                670
Ser Lys Gly Lys Val Arg Arg Gln Asn Ser Leu Lys Glu Trp Arg Asn 
         675                680                685
Leu Lys Gln Lys Arg Asp Glu Asn Tyr Gln Lys Val Met Cys Cys Leu 
     690                695                700
Val His Arg Tyr Leu Thr Ser Met Arg Gln Lys Met Gln Ser Thr Asp 
 705                710                715                720
Gln Ala Thr Val Glu Asn Leu Asn Glu Leu Arg Gln Asp Leu Ser Lys 
                 725                730                735
Phe Arg Asn Glu Ile Arg Asp Leu Leu Gly Phe Arg Thr Ser Lys Tyr 
             740                745                750
Ala Met Phe Tyr Pro Lys Asn 
         755



<210> 918
<211> 5554
<212> DNA
<213> Homo sapiens
<308> Z73903
<400> 918

gaattccga  ctctcgtcc  cttcctggg  taggccgcc  caggcgcgg  ccctgcgac  60
cctggcacg  ccccgtgct  ggctgccgc  ctggcgcgc  ccacactgt  gtccccgga  120
gggcgcgga  cggctcggc  ggggcgccg  cggctgggg  ggggtcgct  gccccgggg  180
cgcgcatgc  ccgccacca  cttggggct  tcagtggag  gcgagtgct  gttctcagg  240
gaggcgacg  cttcgggcc  acgggcctc  agccgaggc  gcagtggga  cgactcatc  300
tttttccag  cctggggcg  ggctggggt  ggggtcggg  tcggggccg  tgggggccc  360
gcccccgtc  cctggcctg  ccccttcat  ggccgcgat  atggcggcc  tgtacccga  420
cacggacct  tcgggcgcc  cctcctcct  cctgccttc  tctccatcc  cttcctcgc  480
gaacgaggt  atggcgctg  aggatgtgc  ggaggtgaa  gaggagaat  cgctgaatg  540
gaagctttt  ttgctggcg  gcgacaagg  tgactatta  atggttaaa  agattttgg  600
ggaaaacag  tcaggtgac  tgaacataa  ttgcgtaga  gtgcttggg  gaaatgctg  660
taccataac  attgaaaac  aaaacttgg  tatactgca  cttcttttg  actacggtt  720
tcagaaact  atggaacga  ttcagaatc  tgagtattc  acaactatg  atgttgcac  780
tgtcatttt  gctgctcat  gtaacaact  tgaaattct  acaatgctc  taaaacagg  840
tgtatctct  cccaagccc  atgcagttg  ctgtgaatg  acattgtgt  ctgcaaaaa  900
caaaaagga  agcctccgg  attccaggt  tcgtcttga  atatatcga  gtttggcca  960
tccagctct  ataatgtta  cagaggagg  tccaattct  agagcattt  aacttagtg  1020
tgatttaaa  gaactaagt  ttgtggagg  ggaattcag  aatgattat  aggaactag  1080
ccggcaatg  aaaatgttt  ctaaggatt  acttgcaca  gcccggaat  ctcgtgaat  1140
ggaagttat  ctaaaccat  cgtctagtg  cgagcctct  gacaaacgg  gattattag  1200
agaaagaat  aatttaagt  gtctaaaac  tgctatcaa  tataaccag  aagagtttg  1260
ctcccagtc  aactgccag  agttcctga  cactgtttg  tttggacag  tgtcgggtt  1320
ccgacgcaa  cccacctgt  agaagataa  gactgtttt  acagtaggc  tcttttggc  1380
agttttgtc  ctttgttat  tgatagctc  caaatctca  tttggcaga  tcattcaca  1440
accttttat  aaatttatc  ttcatggag  atcatattt  acatttctg  tgttgctta  1500
tctatactc  cttgtttac  atgaggata  gaaaaacac  atggggcca  cccttgaaa  1560
aatagacta  cttcttatt  tgtggatta  tgggatgat  tggtcagac  ttaaaagac  1620
ctggtatga  gggttggaa  actttttag  agaatctcg  aatcaactc  gttttgtca  1680
gaattctct  tatttggca  cctttgccc  caaagtggt  gctcacaac  agtttcatg  1740
ttttgctga  cggaaggat  gggatgcat  ccatcctac  ctggtggca  aagggcttt  1800
tgcatttgc  aatgttcta  gttatcttc  tctcttttt  atgtataca  ccagctcta  1860
cttgggtcc  ttacagatt  caatgggac  gatgttaca  gattttgga  aatttcttg  1920
gatgtttct  cttgttttg  tttctttca  aattggact  acacaactg  atgataaag  1980
atatacttc  aaggagcag  aggactgtg  aggcatctt  tgtgaacag  aaagcaatg  2040
taccttcca  tcgttcatt  gcacctgct  tgctttgtt  tggtatatt  tctccttag  2100
gcatgtggc  atctttgtc  caagattta  ctatggaga  gaactgcag  cctttgtgg  2160
agctgtcat  gttggtaca  acaatgtcg  ggttgtgat  gtgcttacc  aactgctgg  2220
ggcaatgct  cataaaagc  ttcagttga  agcaaatca  gaagacaaa  aatggaagt  2280
tgctcgagc  aaattatgg  ttagctact  tgatgacaa  tgtacgtta  ctccacctt  2340
caacatcat  ccctcacca  agactatct  ctatatgat  agtagcctc  gtaagtgga  2400
ttgctctca  acatcaaaa  gcaaggtca  acggcaaaa  agtttaaag  aatggagga  2460
tttgaaaca  aagagagat  aaaactatc  aaaagtgat  tgctgccta  tgcatcgtt  2520
cttgacttc  atgagacag  agatgcaaa  tacagatca  gcaactgtg  aaaatctaa  2580
cgaactgcg  caagatctg  caaaattcc  aaatgaaat  agggattta  ttggctttc  2640
gacttctaa  tatgctatg  tttatccaa  aaattaacc  ttttctaaa  catggagcg  2700
ataattttc  ataacagat  caaaagact  tattgcata  cttgcaatg  aattaatga  2760
atatatatt  aaataaaga  ttatgtaaa  gccattctt  aaaatattt  tagcataaa  2820
atatgttat  taaagtgtg  atatagaat  agtttttta  nccttctgt  agtggcttt  2880
tgcagaagc  aaacagatt  agtagatag  ttttgttag  atgctgctt  gttttctta  2940
ttagtgctt  aaaatgttt  tttttatgt  taagagggg  agttataaa  ggacacatt  3000
cccagaatn  tttgtaana  gaagaccag  aaatgtagg  tgatctcct  cacaggata  3060
acttgaaat  tagaagtta  gttttaaat  tctctgttt  aggagttca  atatagttc  3120
gcatttatt  tttaggagt  taattttat  ttatctaaa  taatagtct  ttttttctt  3180
tgtattttg  tataatctt  agcaacaaa  aaaaaaccc  aatatttga  tctatttat  3240
tctttcaat  taaattcac  tcagttttt  ttattgtaa  atatttact  ttacatggt  3300
ataatcact  tatattttt  atgtttttt  cacttaata  tttatatat  catttccat  3360
tattgatgt  gttagtcca  atttaaatt  ttatagaat  atatagttt  tgaaaaata  3420
agtcagtag  tgttttatt  tttagctat  cagttatgt  tataagttt  catagctac  3480
tctcgacat  tggtttgtt  taatttttt  gtatcataa  agtcctatt  ttttttcaa  3540
ttggagtga  tgtttttag  tttaagata  ataggagac  cttttttat  acatgtagt  3600
acaacctgt  ttgtttttg  aaaacatag  aagtctctt  aatgcaatg  tttgtttta  3660
atttggact  aggttcttg  gcttatctc  caaggtact  tccataatt  aacacagct  3720
ctataaaag  gacttcatg  ttacttgtg  atcattctt  ctgcttaag  tgaaaagca  3780
tggtttttt  aaattagag  ataaaatat  tatttaaat  tttggtgtg  tcacataaa  3840
ngatgtagc  aaaatgttt  cataggcta  tatatatnc  cgcagcatt  ccagttaag  3900
ggatattag  tatataatt  tcttcttaa  cgaatgtca  atggtctta  gccacaggg  3960
gcaggtaac  cttggcctg  aagcaccac  gatccaggg  tcattgtct  aataggtta  4020
tattgtttg  ttcatctgg  attccgagg  tgcacaaat  accagcagc  tgagggagg  4080
cttattgga  ggcttcctg  aggaggtgg  atctgatcc  ggcctagac  tgggagttg  4140
aattttcca  acagggaag  gcactgtgg  tggaaaaca  agcacgaac  aacgtatgg  4200
gtgggacca  gcctcacat  gtgcataaa  gatcagagg  gaggctgaa  cctaggtgt  4260
tgtcagggg  agagctaga  aggaaggtg  ggcagggaa  ctcagtgag  gtctgctac  4320
tgtgaggct  cattctgag  accaactct  cgcgctaat  ccacgaagt  gagtcatga  4380
tcttccatt  tccaggtga  gaaaccaaa  cacggggag  attagcttg  ccaagggct  4440
atggccagt  ggtggtgcc  ctgggattt  accagggat  ccagctgtg  aagctgcat  4500
ctgccagct  agcactccg  ctgtccacc  tggcaaatg  catgctgag  gctgggggc  4560
gtcatcttt  cagcagttg  cgaccagaa  taatgataa  gcatcagcc  ggtgggcaa  4620
aactcagac  ttgtggtca  acctcgctg  ggcagggag  ttagaaaag  cacttttcc  4680
ccacagctg  gtaacatgg  gaaaggggg  tgctcagct  acctctcat  gcccttgtg  4740
ggggatttc  agggtaaat  ctggaaaag  actgaatat  cagcactta  tagaggctt  4800
gcaagcggc  gtcctcacc  aaacggatc  ttccccagg  aagctctgc  aatggagcc  4860
cttggcttt  tgcctgatg  catattccg  tgtttaaaa  ggcgatccc  aacttaaga  4920
tatgaaagg  gtgttttgc  gacaatgca  aattaacca  ttctaaaca  agggtgtgc  4980
aggctccct  aaagctgtt  attattctt  attagtgat  ttaagttaa  gtaaaataa  5040
cctggagct  tgccagagg  tcgggcagg  gaaggagca  agccgctta  ttcaactag  5100
aaacggaaa  aaatcttca  ggggcgcct  tgcgttctg  cttggttgt  gggagatgc  5160
tctatagac  ctttagctc  gcccaaagg  cattgtggg  ggcggcaag  cctctccca  5220
gttcccaga  cccagccga  ctcagggta  tttggttaa  gaaatagtt  aggtgggaa  5280
aaaatatgg  ggagagtag  atacccatc  cccagcttc  aaaataagc  gttaatggt  5340
tggtggact  cccctgtgg  ccaccccac  aatcttatc  ctttcctgc  tccccagag  5400
taagcctaa  cagtccctc  tgtttggtg  gtagatttc  catgcacat  tttttaaat  5460
gctgtaggt  catagtaag  gtatatatt  atggggtac  tgagatgtt  tgacacagg  5520
acgcaatgt  aaatacaca  ttcatggag  attc  5554



<210> 919
<211> 793
<212> PRT
<213> Homo sapiens
<308> P48995
<400> 919

Met Met Ala Ala Leu Tyr Pro Ser Thr Asp Leu Ser Gly Ala Ser Ser 
  1               5                  10                  15
Ser Ser Leu Pro Ser Ser Pro Ser Ser Ser Ser Pro Asn Glu Val Met 
             20                  25                  30
Ala Leu Lys Asp Val Arg Glu Val Lys Glu Glu Asn Thr Leu Asn Glu 
         35                  40                  45
Lys Leu Phe Leu Leu Ala Cys Asp Lys Gly Asp Tyr Tyr Met Val Lys 
     50                  55                  60
Lys Ile Leu Glu Glu Asn Ser Ser Gly Asp Leu Asn Ile Asn Cys Val 
 65                  70                  75                  80
Asp Val Leu Gly Arg Asn Ala Val Thr Ile Thr Ile Glu Asn Glu Asn 
                 85                  90                  95
Leu Asp Ile Leu Gln Leu Leu Leu Asp Tyr Gly Cys Gln Ser Ala Asp 
             100                105                110
Ala Leu Leu Val Ala Ile Asp Ser Glu Val Val Gly Ala Val Asp Ile 
         115                120                125
Leu Leu Asn His Arg Pro Lys Arg Ser Ser Arg Pro Thr Ile Val Lys 
     130                135                140
Leu Met Glu Arg Ile Gln Asn Pro Glu Tyr Ser Thr Thr Met Asp Val 
 145                150                155                160
Ala Pro Val Ile Leu Ala Ala His Arg Asn Asn Tyr Glu Ile Leu Thr 
                 165                170                175
Met Leu Leu Lys Gln Asp Val Ser Leu Pro Lys Pro His Ala Val Gly 
             180                185                190
Cys Glu Cys Thr Leu Cys Ser Ala Lys Asn Lys Lys Asp Ser Leu Arg 
         195                200                205
His Ser Arg Phe Arg Leu Asp Ile Tyr Arg Cys Leu Ala Ser Pro Ala 
     210                215                220
Leu Ile Met Leu Thr Glu Glu Asp Pro Ile Leu Arg Ala Phe Glu Leu 
 225                230                235                240
Ser Ala Asp Leu Lys Glu Leu Ser Leu Val Glu Val Glu Phe Arg Asn 
                 245                250                255
Asp Tyr Glu Glu Leu Ala Arg Gln Cys Lys Met Phe Ala Lys Asp Leu 
             260                265                270
Leu Ala Gln Ala Arg Asn Ser Arg Glu Leu Glu Val Ile Leu Asn His 
         275                280                285
Thr Ser Ser Asp Glu Pro Leu Asp Lys Arg Gly Leu Leu Glu Glu Arg 
     290                295                300
Met Asn Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Asn Gln Lys Glu 
 305                310                315                320
Phe Val Ser Gln Ser Asn Cys Gln Gln Phe Leu Asn Thr Val Trp Phe 
                 325                330                335
Gly Gln Met Ser Gly Tyr Arg Arg Lys Pro Thr Cys Lys Lys Ile Met 
             340                345                350
Thr Val Leu Thr Val Gly Ile Phe Trp Pro Val Leu Ser Leu Cys Tyr 
         355                360                365
Leu Ile Ala Pro Lys Ser Gln Phe Gly Arg Ile Ile His Thr Pro Phe 
     370                375                380
Met Lys Phe Ile Ile His Gly Ala Ser Tyr Phe Thr Phe Leu Leu Leu 
 385                390                395                400
Leu Asn Leu Tyr Ser Leu Val Tyr Asn Glu Asp Lys Lys Asn Thr Met 
                 405                410                415
Gly Pro Ala Leu Glu Arg Ile Asp Tyr Leu Leu Ile Leu Trp Ile Ile 
             420                425                430
Gly Met Ile Trp Ser Asp Ile Lys Arg Leu Trp Tyr Glu Gly Leu Glu 
         435                440                445
Asp Phe Leu Glu Glu Ser Arg Asn Gln Leu Ser Phe Val Met Asn Ser 
     450                455                460
Leu Tyr Leu Ala Thr Phe Ala Leu Lys Val Val Ala His Asn Lys Phe 
 465                470                475                480
His Asp Phe Ala Asp Arg Lys Asp Trp Asp Ala Phe His Pro Thr Leu 
                 485                490                495
Val Ala Glu Gly Leu Phe Ala Phe Ala Asn Val Leu Ser Tyr Leu Arg 
             500                505                510
Leu Phe Phe Met Tyr Thr Thr Ser Ser Ile Leu Gly Pro Leu Gln Ile 
         515                520                525
Ser Met Gly Gln Met Leu Gln Asp Phe Gly Lys Phe Leu Gly Met Phe 
     530                535                540
Leu Leu Val Leu Phe Ser Phe Thr Ile Gly Leu Thr Gln Leu Tyr Asp 
 545                550                555                560
Lys Gly Tyr Thr Ser Lys Glu Gln Lys Asp Cys Val Gly Ile Phe Cys 
                 565                570                575
Glu Gln Gln Ser Asn Asp Thr Phe His Ser Phe Ile Gly Thr Cys Phe 
             580                585                590
Ala Leu Phe Trp Tyr Ile Phe Ser Leu Ala His Val Ala Ile Phe Val 
         595                600                605
Thr Arg Phe Ser Tyr Gly Glu Glu Leu Gln Ser Phe Val Gly Ala Val 
     610                615                620
Ile Val Gly Thr Tyr Asn Val Val Val Val Ile Val Leu Thr Lys Leu 
 625                630                635                640
Leu Val Ala Met Leu His Lys Ser Phe Gln Leu Ile Ala Asn His Glu 
                 645                650                655
Asp Lys Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe 
             660                665                670
Asp Asp Lys Cys Thr Leu Pro Pro Pro Phe Asn Ile Ile Pro Ser Pro 
         675                680                685
Lys Thr Ile Cys Tyr Met Ile Ser Ser Leu Ser Lys Trp Ile Cys Ser 
     690                695                700
His Thr Ser Lys Gly Lys Val Lys Arg Gln Asn Ser Leu Lys Glu Trp 
 705                710                715                720
Arg Asn Leu Lys Gln Lys Arg Asp Glu Asn Tyr Gln Lys Val Met Cys 
                 725                730                735
Cys Leu Val His Arg Tyr Leu Thr Ser Met Arg Gln Lys Met Gln Ser 
             740                745                750
Thr Asp Gln Ala Thr Val Glu Asn Leu Asn Glu Leu Arg Gln Asp Leu 
         755                760                765
Ser Lys Phe Arg Asn Glu Ile Arg Asp Leu Leu Gly Phe Arg Thr Ser 
     770                775                780
Lys Tyr Ala Met Phe Tyr Pro Arg Asn 
 785                790



<210> 920
<211> 3559
<212> DNA
<213> Rattus norvegicus
<308> AF061443
<400> 920

ccatctaag  ntaaanact  caaagcact  acatcgctc  gcaatgccg  gcccgctag  60
gctgctctg  ttcctcgcc  tggggctgc  cggctcggc  gggcccagc  gcgcggcgc  120
gcctctctg  gcggcgccc  gcagctgcg  cggcgaccg  cgggtggac  gctccggaa  180
ggggttgac  gccgtaccg  agggtctca  cgccttcac  caagcactg  atatcagta  240
gaacaatat  acccagtta  cagaagatg  atttaagag  ttcccattt  tagaggagc  300
acaactggc  ggtaacgac  tttctctta  ccatccaaa  gccttgtct  ggctgaaag  360
actcaaagt  ctaacactc  agaataatc  gttgagaac  gtgcccagt  aagccattc  420
cggactgag  gctttgcag  ctttacgct  agatgccaa  catattacc  cagtcccgg  480
ggacagttt  gaagggctt  tccagttac  ccatctgtg  ctggatgac  acagcttga  540
ggaagtgcc  gtgcgtccc  tcagcaacc  gccaaccct  caggcgctg  ccttggctc  600
caacaacat  tcaagcatc  ctgacttcg  tttcaccaa  ctttcaagc  tggtggttc  660
gcatctgca  aacaataaa  ttaaaagcc  cagtcaaca  tgttttgat  gactagata  720
cctggaaac  ttggacttg  attacaatt  cttggatga  tttcctcag  ctattaaag  780
ccttcccag  cttaaagag  tgggatttc  cagtaattc  atttctgtt  ttcctgatg  840
agcatttgg  ggtaatcca  tgctaagaa  tattcattt  tatgataat  ctctgtctt  900
tgtggggaa  tcagcattt  acaacctgt  tgatctgca  tgcttagtc  ttcgtggtg  960
aagcctggt  cagtggttc  ccaatctga  cggaactgt  catttggag  gtctaacct  1020
gacagggac  aaaataagc  gcatacctg  tgatctgtg  caaaaccaa  agatgctga  1080
gactctgga  ttatcttat  acaatataa  agaccttcc  agttttaat  gttgtcgtg  1140
attggaaga  atttcattg  agcgtaatc  aatctccct  ataaaggaa  atacttttc  1200
aggcctaac  tctctaagg  ttctagatc  gagtagaaa  ctgatccgt  aaattcaca  1260
tggagcttt  gcgaagctt  ggacaatta  taacctgga  gtaagtttc  atgaattaa  1320
ttcatttcc  acggaaggc  taaatgggc  caatcaact  aagcttgtg  gtaacttca  1380
gctgaaaga  gccttggca  ccagagact  tgctaatct  aggtctcta  cagtaccat  1440
tgcttatca  tgttgtgca  tttgggggt  tgactctta  gcaaattta  acacagaag  1500
taacagccc  caagaacac  gtgtgacaa  agagaaagg  gctacagat  cagcaaatg  1560
caccagcac  gctgagaac  aagaacata  ccaaataat  atccactgt  caccttcaa  1620
aggtgcttt  aagccctgt  aatatttac  gggaagctg  atgattcgc  ttacagtgt  1680
gttcatttt  ctggtcgcc  tgcttttca  cctgcttgt  attttaaca  tgtttgcgt  1740
ttgttcatc  ctgcctgcc  ccaaactct  cataggctt  atttctgtg  ctaacttac  1800
catgggcat  tatactggc  tccttactt  tcttgatgc  gtgtcctgg  gccgatttg  1860
cgaatttgg  atttggtgg  aaactggca  cggctgcaa  gtagccggg  ctctggcag  1920
cttctcctc  gagagcgct  tattcctat  aacactggc  gctgtggaa  gaagcgtat  1980
tgcaaagga  ttgatgaaa  acgggaaga  cagtcacct  agacagttc  aggtggccg  2040
cctcttagc  ttgctgggt  ccgcagtgg  aggctgctt  ccccttttc  acggagggc  2100
atattctgc  tcgcccttg  gtttgccgt  tcctacagg  gaaacccca  cgttaggat  2160
cactgtgac  ttagtgcta  taaactcac  ggcattttt  ctaatggcc  ttatctaca  2220
taaactata  tgcaactta  agaaggagg  cctgtcgga  aactcccag  ctagcgtga  2280
taagcacgt  gcctggctc  tcttcacaa  ctgcatctt  ttctgccct  ttgcatttt  2340
ctcatttgc  ccattgatc  cggcaatct  catcagccc  gagataatg  agtctgtta  2400
actgatatt  ttcccgttg  ctgcttgcc  gaatccggt  ctgtatgtt  tcttcaacc  2460
aaagtttaa  gaagactgg  agctactga  gcggcgtgt  accaggaaa  acggatctg  2520
ttcagtttc  atcagcagc  aaggcggtt  tggggaaca  gatttctac  atgactgtg  2580
catgtattc  cacttgcag  gtaacctga  tgtctgtga  tgctgtgag  catttcttt  2640
gacaaaacc  gtatcatgc  aacacttaa  aaaatcgca  agttgtcct  tattgacag  2700
ggcctcttg  cagaggcca  aggcctact  gtctgattg  ggtacacag  cagcccatt  2760
tgactatgc  gatgaagaa  attcctttg  ctcagacag  tctgaccag  tgcaggcct  2820
tggacgagc  tgcttctac  agagtcgtg  attccctct  gtgcgctat  cttacaatc  2880
acagagagt  agagactga  ctccagtgt  tgcctgcga  tgtttttcc  catcaacca  2940
atcacagtg  tggcatggg  gctatctgt  tttagacct  tcatctgga  agcacttgt  3000
gaatcactt  ctggtgtca  gcagaagag  aggaaggtg  cagtttatt  ctcagatca  3060
acatctgtg  agaatgggt  cctaaacta  aaattgttg  aaaaaaatt  tgatgcccc  3120
gtaatgtgt  ctctattct  aataaatgc  acttgaaaa  ggtttgatg  atggcatag  3180
aatataaaa  tagggtttt  ttttttttc  ttctgatcc  tcaggtgca  agttcaaac  3240
atttctgaa  taagcacaa  ataaaggac  gctgttaat  tattttaaa  gaaaatgng  3300
aattgtaaa  ctaagaaaa  gccttgcta  tttcaccta  tgattcatc  ttaatctca  3360
gntgactga  ttcagggcc  caaaagaga  tgtctccca  ctagagtta  gnagagttc  3420
aacaggcat  cccttcatg  gttttctgt  tccataaat  aaaggttct  ttcaaatga  3480
ttgtaaatc  aaaacctga  gatgtttta  ggactattg  cagctgtta  attttgggt  3540
ccgagctcg  attcgtaat  3559



<210> 921
<211> 951
<212> PRT
<213> Rattus norvegicus
<308> Q9Z2H4
<400> 921

Met Pro Gly Pro Leu Gly Leu Leu Cys Phe Leu Ala Leu Gly Leu Leu 
  1               5                  10                  15
Gly Ser Ala Gly Pro Ser Gly Ala Ala Pro Pro Leu Cys Ala Ala Pro 
             20                  25                  30
Cys Ser Cys Asp Gly Asp Arg Arg Val Asp Cys Ser Gly Lys Gly Leu 
         35                  40                  45
Thr Ala Val Pro Glu Gly Leu Ser Ala Phe Thr Gln Ala Leu Asp Ile 
     50                  55                  60
Ser Met Asn Asn Ile Thr Gln Leu Pro Glu Asp Ala Phe Lys Ser Phe 
 65                  70                  75                  80
Pro Phe Leu Glu Glu Leu Gln Leu Ala Gly Asn Asp Leu Ser Leu Ile 
                 85                  90                  95
His Pro Lys Ala Leu Ser Gly Leu Lys Glu Leu Lys Val Leu Thr Leu 
             100                105                110
Gln Asn Asn Gln Leu Arg Thr Val Pro Ser Glu Ala Ile His Gly Leu 
         115                120                125
Ser Ala Leu Gln Ser Leu Arg Leu Asp Ala Asn His Ile Thr Ser Val 
     130                135                140
Pro Glu Asp Ser Phe Glu Gly Leu Val Gln Leu Arg His Leu Trp Leu 
 145                150                155                160
Asp Asp Asn Ser Leu Thr Glu Val Pro Val Arg Pro Leu Ser Asn Leu 
                 165                170                175
Pro Thr Leu Gln Ala Leu Thr Leu Ala Leu Asn Asn Ile Ser Ser Ile 
             180                185                190
Pro Asp Phe Ala Phe Thr Asn Leu Ser Ser Leu Val Val Leu His Leu 
         195                200                205
His Asn Asn Lys Ile Lys Ser Leu Ser Gln His Cys Phe Asp Gly Leu 
     210                215                220
Asp Asn Leu Glu Thr Leu Asp Leu Asn Tyr Asn Tyr Leu Asp Glu Phe 
 225                230                235                240
Pro Gln Ala Ile Lys Ala Leu Pro Ser Leu Lys Glu Leu Gly Phe His 
                 245                250                255
Ser Asn Ser Ile Ser Val Ile Pro Asp Gly Ala Phe Gly Gly Asn Pro 
             260                265                270
Leu Leu Arg Thr Ile His Leu Tyr Asp Asn Pro Leu Ser Phe Val Gly 
         275                280                285
Asn Ser Ala Phe His Asn Leu Ser Asp Leu His Cys Leu Val Ile Arg 
     290                295                300
Gly Ala Ser Leu Val Gln Trp Phe Pro Asn Leu Thr Gly Thr Val His 
 305                310                315                320
Leu Glu Ser Leu Thr Leu Thr Gly Thr Lys Ile Ser Ser Ile Pro Asp 
                 325                330                335
Asp Leu Cys Gln Asn Gln Lys Met Leu Arg Thr Leu Asp Leu Ser Tyr 
             340                345                350
Asn Asn Ile Arg Asp Leu Pro Ser Phe Asn Gly Cys Arg Ala Leu Glu 
         355                360                365
Glu Ile Ser Leu Gln Arg Asn Gln Ile Ser Leu Ile Lys Glu Asn Thr 
     370                375                380
Phe Gln Gly Leu Thr Ser Leu Arg Ile Leu Asp Leu Ser Arg Asn Leu 
 385                390                395                400
Ile Arg Glu Ile His Ser Gly Ala Phe Ala Lys Leu Gly Thr Ile Thr 
                 405                410                415
Asn Leu Asp Val Ser Phe Asn Glu Leu Thr Ser Phe Pro Thr Glu Gly 
             420                425                430
Leu Asn Gly Leu Asn Gln Leu Lys Leu Val Gly Asn Phe Lys Leu Lys 
         435                440                445
Asp Ala Leu Ala Ala Arg Asp Phe Ala Asn Leu Arg Ser Leu Ser Val 
     450                455                460
Pro Tyr Ala Tyr Gln Cys Cys Ala Phe Trp Gly Cys Asp Ser Tyr Ala 
 465                470                475                480
Asn Leu Asn Thr Glu Asp Asn Ser Pro Gln Glu His Ser Val Thr Lys 
                 485                490                495
Glu Lys Gly Ala Thr Asp Ala Ala Asn Val Thr Ser Thr Ala Glu Asn 
             500                505                510
Glu Glu His Ser Gln Ile Ile Ile His Cys Thr Pro Ser Thr Gly Ala 
         515                520                525
Phe Lys Pro Cys Glu Tyr Leu Leu Gly Ser Trp Met Ile Arg Leu Thr 
     530                535                540
Val Trp Phe Ile Phe Leu Val Ala Leu Leu Phe Asn Leu Leu Val Ile 
 545                550                555                560
Leu Thr Val Phe Ala Ser Cys Ser Ser Leu Pro Ala Ser Lys Leu Phe 
                 565                570                575
Ile Gly Leu Ile Ser Val Ser Asn Leu Leu Met Gly Ile Tyr Thr Gly 
             580                585                590
Ile Leu Thr Phe Leu Asp Ala Val Ser Trp Gly Arg Phe Ala Glu Phe 
         595                600                605
Gly Ile Trp Trp Glu Thr Gly Ser Gly Cys Lys Val Ala Gly Ser Leu 
     610                615                620
Ala Val Phe Ser Ser Glu Ser Ala Val Phe Leu Leu Thr Leu Ala Ala 
 625                630                635                640
Val Glu Arg Ser Val Phe Ala Lys Asp Leu Met Lys His Gly Lys Ser 
                 645                650                655
Ser His Leu Arg Gln Phe Gln Val Ala Ala Leu Leu Ala Leu Leu Gly 
             660                665                670
Ala Ala Val Ala Gly Cys Phe Pro Leu Phe His Gly Gly Gln Tyr Ser 
         675                680                685
Ala Ser Pro Leu Cys Leu Pro Phe Pro Thr Gly Glu Thr Pro Ser Leu 
     690                695                700
Gly Phe Thr Val Thr Leu Val Leu Leu Asn Ser Leu Ala Phe Leu Leu 
 705                710                715                720
Met Ala Ile Ile Tyr Thr Lys Leu Tyr Cys Asn Leu Glu Lys Glu Asp 
                 725                730                735
Leu Ser Glu Asn Ser Gln Ser Ser Val Ile Lys His Val Ala Trp Leu 
             740                745                750
Ile Phe Thr Asn Cys Ile Phe Phe Cys Pro Val Ala Phe Phe Ser Phe 
         755                760                765
Ala Pro Leu Ile Thr Ala Ile Ser Ile Ser Pro Glu Ile Met Lys Ser 
     770                775                780
Val Thr Leu Ile Phe Phe Pro Leu Pro Ala Cys Leu Asn Pro Val Leu 
 785                790                795                800
Tyr Val Phe Phe Asn Pro Lys Phe Lys Glu Asp Trp Lys Leu Leu Lys 
                 805                810                815
Arg Arg Val Thr Arg Lys His Gly Ser Val Ser Val Ser Ile Ser Ser 
             820                825                830
Gln Gly Gly Cys Gly Glu Gln Asp Phe Tyr Tyr Asp Cys Gly Met Tyr 
         835                840                845
Ser His Leu Gln Gly Asn Leu Thr Val Cys Asp Cys Cys Glu Ser Phe 
     850                855                860
Leu Leu Thr Lys Pro Val Ser Cys Lys His Leu Ile Lys Ser His Ser 
 865                870                875                880
Cys Pro Val Leu Thr Ala Ala Ser Cys Gln Arg Pro Glu Ala Tyr Trp 
                 885                890                895
Ser Asp Cys Gly Thr Gln Ser Ala His Ser Asp Tyr Ala Asp Glu Glu 
             900                905                910
Asp Ser Phe Val Ser Asp Ser Ser Asp Gln Val Gln Ala Cys Gly Arg 
         915                920                925
Ala Cys Phe Tyr Gln Ser Arg Gly Phe Pro Leu Val Arg Tyr Ala Tyr 
     930                935                940
Asn Leu Gln Arg Val Arg Asp 
 945                950



<210> 922
<211> 4505
<212> DNA
<213> Homo sapiens
<308> XM_006549
<400> 922

acaattggc  ggcaacgac  tttctttta  ccacccaaa  gccttgtct  ggttgaaag  60
actcaaagt  ctaacgctc  agaataatc  gttgaaaac  gtacccagt  aagccattc  120
agggctgag  gctttgcag  ctttgcgtt  agatgccaa  catattacc  cagtccccg  180
ggacagttt  gaaggactt  ttcagttac  gcatctgtg  ctggatgac  acagcttga  240
ggaggtgcc  gtgcacccc  tcagcaatc  gcccaccct  caggcgctg  ccctggctc  300
caacaagat  tcaagcatc  ctgactttg  atttaccaa  ctttcaagc  tggtagttc  360
gcatcttca  aacaataaa  ttagaagcc  gagtcaaca  tgttttgat  gactagata  420
cctggagac  ttagacttg  attataata  cttggggga  tttcctcag  ctattaaag  480
ccttcctag  cttaaagag  taggatttc  tagtaattc  atttctgtt  tccctgatg  540
agcatttga  ggtaatcca  tcttaagaa  tatacattt  tatgataat  ctctgtctt  600
tgtggggaa  tcagcattt  acaatttat  tgatcttca  tccctagtc  ttcgtggtg  660
aagcatggt  cagcagttc  ccaatctta  aggaactgt  cacctggaa  gtctgactt  720
gacaggtac  aagataagc  gcataccta  taatttgtg  caagaacaa  agatgctta  780
gactttgga  ttgtcttac  ataatataa  agaccttcc  agttttaat  gttgccatg  840
tctggaaga  atttcttta  agcgtaatc  aatctacca  ataaaggaa  gcacctttc  900
aggcctgat  tctctaagg  ttctagatc  gagtagaaa  ctgatacat  aaattcaca  960
tagagcttt  gccacactt  ggccaataa  taacctaga  gtaagtttc  atgaattaa  1020
ttcctttcc  acggaaggc  tgaatgggc  aaatcaact  aaacttgtg  gcaacttca  1080
gctgaaaga  gccttagca  caaaagact  tgttaacct  aggtcttta  cagtaccat  1140
tgcttatca  tgctgtgca  tttggggtt  tgactctta  gcaaattta  acacagaag  1200
taacagcct  caggaccac  gtgtggcac  ggagaaagg  actgctgat  cagcaaatg  1260
cacaagcac  cttgaaaat  aagaacata  tcaaataat  atccattgt  caccttcaa  1320
aggtgcttt  aagccctgt  aatatttac  gggaagctg  atgattcgt  ttactgtgt  1380
gttcatttt  ttggttgca  tatttttca  cctgcttgt  attttaaca  catttgcat  1440
ttgtacatc  ctgccttcg  ccaaattgt  tataggctt  atttctgtg  ctaacttat  1500
catgggaat  tatactggc  tcctaactt  tcttgatgc  gtgtcctgg  gcagattcg  1560
tgaatttgg  atttggtgg  aaactggca  tggctgcaa  gtagctggg  ttcttgcag  1620
tttctcctc  gaaagtgcc  tatttttat  aatgctagc  actgtcgaa  gaagcttat  1680
tgcaaaaga  ataatgaaa  atgggaaga  caatcatct  aaacagttc  gggttgctg  1740
ccttttggc  ttcctaggt  ctacagtag  aggctgttt  ccccttttc  atagagggg  1800
atattctgc  tcacccctt  gtttgccat  tcctacagg  gaaacgcca  cattaggat  1860
cactgtaac  ttagtgcta  taaactcac  agcattttt  ttaatggcc  ttatctaca  1920
taaactata  tgcaacttg  aaaaagagg  cctctcaga  aactcacaa  ctagcatga  1980
taagcatgt  gcttggcta  tcttcacca  ttgcatctt  ttctgccct  tggcgtttt  2040
ttcatttgc  ccattgatc  ctgcaatct  tatcagccc  gaaataatg  agtctgtta  2100
tctgatatt  tttccattg  ctgcttgcc  gaatccagt  ctgtatgtt  tcttcaacc  2160
aaagtttaa  gaagactgg  agttactga  gcgacgtgt  accaagaaa  gtggatcag  2220
ttcagtttc  atcagtagc  aaggtggtt  tctggaaca  gatttctac  acgactgtg  2280
catgtactc  catttgcag  gcaacctga  tgtttgcga  tgctgcgaa  cgtttcttt  2340
aacaaagcc  gtatcatgc  aacacttga  aaaatcaca  agctgtcct  cattggcag  2400
ggcttcttg  caaagacct  agggctact  gtccgactg  ggcacacag  cggcccact  2460
tgattatgc  gatgaagaa  attcctttg  ctcagacag  tctgaccag  tgcaggcct  2520
tggacgagc  tgcttctac  agagtagag  attcccttt  gtgcgctat  cttacaatc  2580
accaagagt  aaagactga  ctactgtgt  tgtaaccgt  tcccccgtc  accaaaatc  2640
gtgtttata  agtgaaccc  attctcatc  ttcatctgg  aagcacttc  gtaatcact  2700
cctggtgtc  cttagaaga  ggagaggtg  cagtttatt  ctcaaacca  tcattttca  2760
agaacaggt  cctaaatta  aaattggtg  aaaatgcaa  gtccaagca  tgtatgatc  2820
gtttgaaac  aatatatga  ttgaaaagg  tcttaggtg  agtagagca  tataatgtt  2880
gttttttct  atccataag  agcaaattt  tacctattt  tgtattaag  acaagataa  2940
gaacagctg  taatatttt  taaaaatct  ttttaaaat  tgattttct  taactgaag  3000
aaatatctt  ctaatttta  ctaatgttt  atccttaat  tcaggacaa  ttactgcag  3060
gccaaaaaa  ggactgtcc  agctagaac  gtgagagta  acataggca  tactttatt  3120
tgttttcac  tgccatcct  gacataaga  aactataaa  tttgtttaa  caatttata  3180
atctaaaac  tgaagatgt  tttaaaaca  tattaacag  tgttaggtt  aaaaaatag  3240
tggacattt  ttttcagtc  ttatacatt  ctttggtcc  atcagtaat  ttttcttaa  3300
tgttttgtg  ttacactac  agaaaaaaa  taaaaggct  attgctgtg  gggtttagt  3360
gatttggct  aactactaa  taatgtggg  gtttaatag  atctgaggg  tttggtggc  3420
tcatgtaat  ttctcatta  tgaatactt  ctaatatcg  tggctctac  aatattttc  3480
aatttgctg  gatgtcacc  agcaatagc  tggattata  agaaagtaa  ctgtggtca  3540
tacttgcat  taattagac  aaacgggga  taattatga  acgaagtac  tatgtttat  3600
tcttagtga  ctggattat  ttgaacctg  gctattaaa  ggaaatttc  atacatctt  3660
cccatacta  tttttataa  agagcctat  caatagctc  gaggttgaa  tctggttaa  3720
caagataat  tgttattaa  aaaaataga  gaagaaaga  taaagctta  tcctgtgtc  3780
ttaaaaatt  aaaatttta  ttgattccc  tctatgggc  ttagaccta  tactgggtg  3840
agtcttaaa  ttataattg  tcaatatgt  ttttgaaca  tgtgctaaa  caatagcaa  3900
cccactgcc  tattagtta  tctgaatat  ctaaaaaaa  ccagctaga  tgcagttta  3960
taattaaac  gtacatact  tgcatataa  gaattttta  cttatgtaa  ttattttta  4020
aacacaagt  gggaaatgt  gcttctgtt  atttcgttt  attaaagct  cctcctaaa  4080
tatagtggc  gccagtagc  gactgttaa  ttgtggttt  tatactttt  gcattgtaa  4140
tagtctttg  tgtacattg  cagtgtaat  aaaacagaa  ctttgtata  caaaatcat  4200
tagtttgta  aaaatgtgg  aaggattta  ttacagtgt  ttgtaattt  gtaaggcca  4260
ctatttaca  gttttaaaa  ttgctatca  gtatattta  acatctgat  aatattaaa  4320
cataacttg  taagaaact  ctaattaaa  ggttttttc  aaaattcag  ttattgaaa  4380
cttttcatt  tattcattt  aaaactaga  taacagata  ataaaagtg  taatctttg  4440
gctatatgg  atgaaatac  atattgtac  cagtgtttt  aattattaa  gtttctaga  4500
agcaa  4505



<210> 923
<211> 644
<212> PRT
<213> Homo sapiens
<308> XP_006549
<400> 923

Met Val Gln Gln Phe Pro Asn Leu Thr Gly Thr Val His Leu Glu Ser 
  1               5                  10                  15
Leu Thr Leu Thr Gly Thr Lys Ile Ser Ser Ile Pro Asn Asn Leu Cys 
             20                  25                  30
Gln Glu Gln Lys Met Leu Arg Thr Leu Asp Leu Ser Tyr Asn Asn Ile 
         35                  40                  45
Arg Asp Leu Pro Ser Phe Asn Gly Cys His Ala Leu Glu Glu Ile Ser 
     50                  55                  60
Leu Gln Arg Asn Gln Ile Tyr Gln Ile Lys Glu Gly Thr Phe Gln Gly 
 65                  70                  75                  80
Leu Ile Ser Leu Arg Ile Leu Asp Leu Ser Arg Asn Leu Ile His Glu 
                 85                  90                  95
Ile His Ser Arg Ala Phe Ala Thr Leu Gly Pro Ile Thr Asn Leu Asp 
             100                105                110
Val Ser Phe Asn Glu Leu Thr Ser Phe Pro Thr Glu Gly Leu Asn Gly 
         115                120                125
Leu Asn Gln Leu Lys Leu Val Gly Asn Phe Lys Leu Lys Glu Ala Leu 
     130                135                140
Ala Ala Lys Asp Phe Val Asn Leu Arg Ser Leu Ser Val Pro Tyr Ala 
 145                150                155                160
Tyr Gln Cys Cys Ala Phe Trp Gly Cys Asp Ser Tyr Ala Asn Leu Asn 
                 165                170                175
Thr Glu Asp Asn Ser Leu Gln Asp His Ser Val Ala Gln Glu Lys Gly 
             180                185                190
Thr Ala Asp Ala Ala Asn Val Thr Ser Thr Leu Glu Asn Glu Glu His 
         195                200                205
Ser Gln Ile Ile Ile His Cys Thr Pro Ser Thr Gly Ala Phe Lys Pro 
     210                215                220
Cys Glu Tyr Leu Leu Gly Ser Trp Met Ile Arg Leu Thr Val Trp Phe 
 225                230                235                240
Ile Phe Leu Val Ala Leu Phe Phe Asn Leu Leu Val Ile Leu Thr Thr 
                 245                250                255
Phe Ala Ser Cys Thr Ser Leu Pro Ser Ser Lys Leu Phe Ile Gly Leu 
             260                265                270
Ile Ser Val Ser Asn Leu Phe Met Gly Ile Tyr Thr Gly Ile Leu Thr 
         275                280                285
Phe Leu Asp Ala Val Ser Trp Gly Arg Phe Ala Glu Phe Gly Ile Trp 
     290                295                300
Trp Glu Thr Gly Ser Gly Cys Lys Val Ala Gly Phe Leu Ala Val Phe 
 305                310                315                320
Ser Ser Glu Ser Ala Ile Phe Leu Leu Met Leu Ala Thr Val Glu Arg 
                 325                330                335
Ser Leu Ser Ala Lys Asp Ile Met Lys Asn Gly Lys Ser Asn His Leu 
             340                345                350
Lys Gln Phe Arg Val Ala Ala Leu Leu Ala Phe Leu Gly Ala Thr Val 
         355                360                365
Ala Gly Cys Phe Pro Leu Phe His Arg Gly Glu Tyr Ser Ala Ser Pro 
     370                375                380
Leu Cys Leu Pro Phe Pro Thr Gly Glu Thr Pro Ser Leu Gly Phe Thr 
 385                390                395                400
Val Thr Leu Val Leu Leu Asn Ser Leu Ala Phe Leu Leu Met Ala Val 
                 405                410                415
Ile Tyr Thr Lys Leu Tyr Cys Asn Leu Glu Lys Glu Asp Leu Ser Glu 
             420                425                430
Asn Ser Gln Ser Ser Met Ile Lys His Val Ala Trp Leu Ile Phe Thr 
         435                440                445
Asn Cys Ile Phe Phe Cys Pro Val Ala Phe Phe Ser Phe Ala Pro Leu 
     450                455                460
Ile Thr Ala Ile Ser Ile Ser Pro Glu Ile Met Lys Ser Val Thr Leu 
 465                470                475                480
Ile Phe Phe Pro Leu Pro Ala Cys Leu Asn Pro Val Leu Tyr Val Phe 
                 485                490                495
Phe Asn Pro Lys Phe Lys Glu Asp Trp Lys Leu Leu Lys Arg Arg Val 
             500                505                510
Thr Lys Lys Ser Gly Ser Val Ser Val Ser Ile Ser Ser Gln Gly Gly 
         515                520                525
Cys Leu Glu Gln Asp Phe Tyr Tyr Asp Cys Gly Met Tyr Ser His Leu 
     530                535                540
Gln Gly Asn Leu Thr Val Cys Asp Cys Cys Glu Ser Phe Leu Leu Thr 
 545                550                555                560
Lys Pro Val Ser Cys Lys His Leu Ile Lys Ser His Ser Cys Pro Ala 
                 565                570                575
Leu Ala Val Ala Ser Cys Gln Arg Pro Glu Gly Tyr Trp Ser Asp Cys 
             580                585                590
Gly Thr Gln Ser Ala His Ser Asp Tyr Ala Asp Glu Glu Asp Ser Phe 
         595                600                605
Val Ser Asp Ser Ser Asp Gln Val Gln Ala Cys Gly Arg Ala Cys Phe 
     610                615                620
Tyr Gln Ser Arg Gly Phe Pro Leu Val Arg Tyr Ala Tyr Asn Leu Pro 
 625                630                635                640
Arg Val Lys Asp 
                 645



<210> 924
<211> 2708
<212> DNA
<213> Rattus norvegicus
<308> AF061726
<400> 924

tcaggcctg  gctgagggt  cagcaggag  ggccgcagg  aaggccggg  tccactgct  60
gtcatcatg  cctacctgc  gccgggatt  ttctgtgac  gagtgatca  agaaaggga  120
aggagaaat  gagagggca  cgtctcaca  cctctcaag  ttgaggggc  ggattttgt  180
gttctcaaa  aacggtgtc  ggctcagaa  tgcctcttt  aagatcgag  cttcccagc  240
ggtacacag  cccttggct  acatgagct  agccagaaa  ccaagatga  ggccatcac  300
tggaagagg  caaaggaaa  ttgtgagaa  ccccgattt  tcattggtg  agccaacag  360
actgacatc  gccaaggag  tctagggga  tgctggttt  ttgcagcca  tgcctgtct  420
accctgaat  agcgactgc  tttccgagt  atacctcat  atcaaagtt  cactgaaaa  480
tacgcaggg  tcttccact  ccagttctg  cgctatgga  actgggtag  tgtggttat  540
gacgactgt  tgccgacat  caacaacca  ctggtcttc  ccaaatcca  ccaccgcaa  600
gagttctgg  gtgctctac  ggagaaagc  tatgccaag  tccatggtt  ctatgaagc  660
ctgaaaggt  ggaacacca  agaagccat  gaggacttc  caggagggg  gacagagtt  720
tttgagatc  aggatgctc  gagtgacat  tacaagatc  tgaggaaag  tatcgagag  780
ggctccctc  tgggctgct  cattgatga  ggcaccaac  tgacttatg  aacctctcc  840
tctggtctg  acatggggg  attgattgc  cggatggtg  gaaatatgg  taactcgct  900
ctcagagac  cagacctgg  ccccagggc  tcagatgac  gaccgtcac  gacaattgt  960
ccggtgcag  atgaaacaa  aatggcctg  ggactggtg  aagggcacg  ctattcagt  1020
actgggctg  aggaggccc  gttcaaagg  gagaaggtg  agctggtgc  gctgcggaa  1080
ccctggggc  aggtggagt  gaacggctc  tggagtgat  gttggaagg  ctggagctt  1140
gtggacaaa  acgagaagg  ccgtctgca  caccaggtc  ccgaggatg  agagttctg  1200
atgtcatat  atgactttg  ctaccattt  acaaagctg  agatctgca  cctcacagc  1260
gatgccctg  agtccgata  gcttcagac  tggacagtg  ctgtaaatg  gggccgctg  1320
gtgaggggc  gttctgctg  aggctgccg  aacttccca  acactttct  gaccaaccc  1380
cagtaccgt  tcaagctcc  ggaggagga  gatgaccct  atgactctg  ggtgatttg  1440
agcttcctc  tggctctga  gcagaaaaa  cggcgcaag  accggaagc  gggggccaa  1500
ctcttcacc  ttggcttcg  tatctacga  gttcccaaa  agatgcacg  gaataagca  1560
cacctgcag  aggacttct  cttgtacaa  gcctccaag  ccaggagca  aacctacat  1620
aacatgcgg  aggtgtccc  gcgcttccg  ctgccgccc  gcgagtatg  cattgtccc  1680
tccacttac  agccccatc  ggaggggga  ttcatcctc  gggtcttct  tgaaaagag  1740
aatctctct  aggaagctg  gaatacaat  tctgtggac  ggccagtgc  acggcctgg  1800
cacacagac  aggagagtg  ggagcagca  caattccgg  acatcttca  gcagattgc  1860
ggcgacgac  tggagatct  tgcggatga  ctcaagaat  tccttaata  ggtggtgaa  1920
aaacacaag  acctgaaga  acaagggtt  actctggag  cctgcagaa  catgatagc  1980
ctcatggat  cagatggct  tgggagact  aatcttcaa  agttccatc  cctctggaa  2040
aagatcaag  cctggcaga  aatcttcaa  cactatgac  ctgaccatt  tggtaccat  2100
aatagctat  agatgcgaa  tgcagtcaa  gatgcaggc  tccatctca  cagccaact  2160
tatgacatc  tcaccatgc  ctacgcaga  aaacacatg  acatcgact  tgacagctt  2220
atctgctgc  tcgtcaggc  ggaagggat  ttcagagct  ttcacgcat  tgacaagga  2280
ggagatggc  tcatcaaac  gaacgtact  gagtggctg  agcttacca  gtatgcctg  2340
accagatga  ctcatgtaa  atcaaccag  attccatct  aacacgaca  agccagggc  2400
gtttaccac  aggaaccca  taggcacac  tccaccaaa  tgggctcct  gtcacgttc  2460
ttctccact  tgacccaag  cttggtgca  agccacctc  agtgtctgg  ttgctggga  2520
ctctgcaga  gctgtctac  tagcttgta  ctgggttgt  cacagccct  tcaccatct  2580
cactcagtt  tgccagttt  agggtgggt  tactctggg  tccataggg  gtggatacc  2640
gacaaaaat  tggctacat  ctgaaagaa  ctatctaaa  aaaggcacg  acatggctg  2700
ttccacca  2708



<210> 925
<211> 821
<212> PRT
<213> Rattus norvegicus
<308> P16259
<400> 925

Met Pro Thr Val Ile Ser Pro Thr Val Ala Pro Arg Thr Gly Ala Glu 
  1               5                  10                  15
Pro Arg Ser Pro Gly Pro Val Pro His Pro Ala Gln Gly Lys Thr Thr 
             20                  25                  30
Glu Ala Gly Gly Gly His Pro Gly Gly Ile Tyr Ser Ala Ile Ile Ser 
         35                  40                  45
Arg Asn Phe Pro Ile Ile Gly Val Lys Glu Lys Thr Phe Glu Gln Leu 
     50                  55                  60
His Lys Lys Cys Leu Glu Lys Lys Val Leu Tyr Leu Asp Pro Glu Phe 
 65                  70                  75                  80
Pro Pro Asp Glu Thr Ser Leu Phe Tyr Ser Gln Lys Phe Pro Ile Gln 
                 85                  90                  95
Phe Val Trp Lys Arg Pro Pro Glu Ile Cys Glu Asn Pro Arg Phe Ile 
             100                105                110
Ile Gly Gly Ala Asn Arg Thr Asp Ile Cys Gln Gly Asp Leu Gly Asp 
         115                120                125
Cys Trp Leu Leu Ala Ala Ile Ala Cys Leu Thr Leu Asn Glu Arg Leu 
     130                135                140
Leu Phe Arg Val Ile Pro His Asp Gln Ser Phe Thr Glu Asn Tyr Ala 
 145                150                155                160
Gly Ile Phe His Phe Gln Phe Trp Arg Tyr Gly Asp Trp Val Asp Val 
                 165                170                175
Val Ile Asp Asp Cys Leu Pro Thr Tyr Asn Asn Gln Leu Val Phe Thr 
             180                185                190
Lys Ser Asn His Arg Asn Glu Phe Trp Ser Ala Leu Leu Glu Lys Ala 
         195                200                205
Tyr Ala Lys Leu His Gly Ser Tyr Glu Ala Leu Lys Gly Gly Asn Thr 
     210                215                220
Thr Glu Ala Met Glu Asp Phe Thr Gly Gly Val Thr Glu Phe Phe Glu 
 225                230                235                240
Ile Lys Asp Ala Pro Ser Asp Met Tyr Lys Ile Met Arg Lys Ala Ile 
                 245                250                255
Glu Arg Gly Ser Leu Met Gly Cys Ser Ile Asp Asp Gly Thr Asn Met 
             260                265                270
Thr Tyr Gly Thr Ser Pro Ser Gly Leu Asn Met Gly Glu Leu Ile Ala 
         275                280                285
Arg Met Val Arg Asn Met Asp Asn Ser Leu Leu Arg Asp Ser Asp Leu 
     290                295                300
Asp Pro Arg Ala Ser Asp Asp Arg Pro Ser Arg Thr Ile Val Pro Val 
 305                310                315                320
Gln Tyr Glu Thr Arg Met Ala Cys Gly Leu Val Lys Gly His Ala Tyr 
                 325                330                335
Ser Val Thr Gly Leu Glu Glu Ala Leu Phe Lys Gly Glu Lys Val Lys 
             340                345                350
Leu Val Arg Leu Arg Asn Pro Trp Gly Gln Val Glu Trp Asn Gly Ser 
         355                360                365
Trp Ser Asp Gly Trp Lys Asp Trp Ser Phe Val Asp Lys Asp Glu Lys 
     370                375                380
Ala Arg Leu Gln His Gln Val Thr Glu Asp Gly Glu Phe Trp Met Ser 
 385                390                395                400
Tyr Asp Asp Phe Val Tyr His Phe Thr Lys Leu Glu Ile Cys Asn Leu 
                 405                410                415
Thr Ala Asp Ala Leu Glu Ser Asp Lys Leu Gln Thr Trp Thr Val Ser 
             420                425                430
Val Asn Glu Gly Arg Trp Val Arg Gly Cys Ser Ala Gly Gly Cys Arg 
         435                440                445
Asn Phe Pro Asp Thr Phe Trp Thr Asn Pro Gln Tyr Arg Leu Lys Leu 
     450                455                460
Leu Glu Glu Asp Asp Asp Pro Asp Asp Ser Glu Val Ile Cys Ser Phe 
 465                470                475                480
Leu Val Ala Leu Met Gln Lys Asn Arg Arg Lys Asp Arg Lys Leu Gly 
                 485                490                495
Ala Asn Leu Phe Thr Ile Gly Phe Ala Ile Tyr Glu Val Pro Lys Glu 
             500                505                510
Met His Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn 
         515                520                525
Ala Ser Lys Ala Arg Ser Lys Thr Tyr Ile Asn Met Arg Glu Val Ser 
     530                535                540
Gln Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Thr 
 545                550                555                560
Tyr Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu 
                 565                570                575
Lys Arg Asn Leu Ser Glu Glu Ala Glu Asn Thr Ile Ser Val Asp Arg 
             580                585                590
Pro Val Lys Lys Lys Lys Asn Lys Pro Ile Ile Phe Val Ser Asp Arg 
         595                600                605
Ala Asn Ser Asn Lys Glu Leu Gly Val Asp Gln Glu Ala Glu Glu Gly 
     610                615                620
Lys Asp Lys Thr Gly Pro Asp Lys Gln Gly Glu Ser Pro Gln Pro Arg 
 625                630                635                640
Pro Gly His Thr Asp Gln Glu Ser Glu Glu Gln Gln Gln Phe Arg Asn 
                 645                650                655
Ile Phe Arg Gln Ile Ala Gly Asp Asp Met Glu Ile Cys Ala Asp Glu 
             660                665                670
Leu Lys Asn Val Leu Asn Thr Val Val Asn Lys His Lys Asp Leu Lys 
         675                680                685
Thr Gln Gly Phe Thr Leu Glu Ser Cys Arg Ser Met Ile Ala Leu Met 
     690                695                700
Asp Thr Asp Gly Ser Gly Arg Leu Asn Leu Gln Glu Phe His His Leu 
 705                710                715                720
Trp Lys Lys Ile Lys Ala Trp Gln Lys Ile Phe Lys His Tyr Asp Thr 
                 725                730                735
Asp His Ser Gly Thr Ile Asn Ser Tyr Glu Met Arg Asn Ala Val Asn 
             740                745                750
Asp Ala Gly Phe His Leu Asn Ser Gln Leu Tyr Asp Ile Ile Thr Met 
         755                760                765
Arg Tyr Ala Asp Lys His Met Asn Ile Asp Phe Asp Ser Phe Ile Cys 
     770                775                780
Cys Phe Val Arg Leu Glu Gly Met Phe Arg Ala Phe His Ala Phe Asp 
 785                790                795                800
Lys Asp Gly Asp Gly Ile Ile Lys Leu Asn Val Leu Glu Trp Leu Gln 
                 805                810                815
Leu Thr Met Tyr Ala 
             820



<210> 926
<211> 1661
<212> DNA
<213> Homo sapiens
<308> BC003169
<400> 926

ccctcctcc  cgcttacag  cacacacac  gtcacacag  cgcgttctg  gggtggctg  60
ccgcttggg  tggaggaat  acttccctc  gaacccagc  aagtcctct  ggcctcctt  120
ggggtcctt  cagcctgag  ggcttcgga  ctgaggagc  gctgttctg  tgcacggga  180
caagcagca  ctgcagaag  acttcttcc  gtacaacgc  tccaaggcc  ggagcaaaa  240
ctacatcaa  atgcgggag  tgtcccagc  cttccgcct  cctcccagc  agtacgtca  300
cgtgccctc  acctacgag  cccaccagg  gggggaatt  atcctccgg  tcttctctg  360
aaagaggaa  ctctctgag  aagttgaaa  taccatctc  gtggatcgg  cagtgaaaa  420
gaaaaaaac  aagcccatc  tcttcgttt  ggacagagc  aacagcaac  aggagctgg  480
tgtggacca  gagtcagag  agggcaaag  caaaacaag  cctgataag  aaaagcagt  540
cccacagcc  cagcctggc  gctctgatc  ggaaagtga  gaacagcaa  aattccgga  600
cattttcaa  cagatagca  gagatgaca  ggagatctg  gcagatgag  tcaagaagg  660
ccttaacac  gtcgtgaac  aacacaagg  cctgaagac  cacgggttc  cactggagt  720
ctgccgtag  atgattgcg  tcatggata  agatggctc  ggaaagctc  acctgcagg  780
gttccacca  ctctggaac  agattaagg  ctggcagaa  attttcaaa  actatgaca  840
agaccagtc  ggcaccatc  acagctacg  gatgcgaaa  gcagtcaac  acgcaggat  900
ccacctcaa  aaccagctc  atgacatca  taccatgcg  tacgcagac  aacacatga  960
catcgactt  gacagtttc  tctgctgct  cgttaggct  gagggcatg  tcagagctt  1020
tcatgcatt  gacaaggat  gagatggta  catcaagct  aacgttctg  agtggctgc  1080
gctcaccat  tatgcctga  ccaggctgg  ctcatccaa  gccatgcag  atcactcag  1140
atttcagtt  caccctcta  ttccaaagc  atttacctc  aaggaccca  cagctacac  1200
cctacaggc  tccaggcac  tcatcagtc  tgttcctcc  ccattttac  ccctaccca  1260
ccttgatcg  tcatgccta  cctgaccct  tagtaaagc  atgaggtag  aagaacaaa  1320
ccttgtccc  ttgccatgt  gaggaaagt  cctgcctct  gtccgagcc  cctcggttc  1380
gaagcgagt  ctcctgctt  ccttgctct  ggctgtctg  agaagcacc  gccggtggc  1440
ctcagcacc  ccttgtgct  gagccctcc  tcaccttca  gctgtccca  catgggcca  1500
gaaccaaac  agcactggg  tctactgct  tggggtaaa  taactcagt  gaatagggc  1560
ggttacttt  ggctgtcca  ctcataagt  tggctgcat  ttgaaaaaa  ctgatctaa  1620
taaaggcat  tgtatggct  gtcaaaaaa  aaaaaaaaa  a  1661



<210> 927
<211> 821
<212> PRT
<213> Homo sapiens
<308> P20807
<400> 927

Met Pro Thr Val Ile Ser Ala Ser Val Ala Pro Arg Thr Ala Ala Glu 
  1               5                  10                  15
Pro Arg Ser Pro Gly Pro Val Pro His Pro Ala Gln Ser Lys Ala Thr 
             20                  25                  30
Glu Ala Gly Gly Gly Asn Pro Ser Gly Ile Tyr Ser Ala Ile Ile Ser 
         35                  40                  45
Arg Asn Phe Pro Ile Ile Gly Val Lys Glu Lys Thr Phe Glu Gln Leu 
     50                  55                  60
His Lys Lys Cys Leu Glu Lys Lys Val Leu Tyr Val Asp Pro Glu Phe 
 65                  70                  75                  80
Pro Pro Asp Glu Thr Ser Leu Phe Tyr Ser Gln Lys Phe Pro Ile Gln 
                 85                  90                  95
Phe Val Trp Lys Arg Pro Pro Glu Ile Cys Glu Asn Pro Arg Phe Ile 
             100                105                110
Ile Asp Gly Ala Asn Arg Thr Asp Ile Cys Gln Gly Glu Leu Gly Asp 
         115                120                125
Cys Trp Phe Leu Ala Ala Ile Ala Cys Leu Thr Leu Asn Gln His Leu 
     130                135                140
Leu Phe Arg Val Ile Pro His Asp Gln Ser Phe Ile Glu Asn Tyr Ala 
 145                150                155                160
Gly Ile Phe His Phe Gln Phe Trp Arg Tyr Gly Glu Trp Val Asp Val 
                 165                170                175
Val Ile Asp Asp Cys Leu Pro Thr Tyr Asn Asn Gln Leu Val Phe Thr 
             180                185                190
Lys Ser Asn His Arg Asn Glu Phe Trp Ser Ala Leu Leu Glu Lys Ala 
         195                200                205
Tyr Ala Lys Leu His Gly Ser Tyr Glu Ala Leu Lys Gly Gly Asn Thr 
     210                215                220
Thr Glu Ala Met Glu Asp Phe Thr Gly Gly Val Ala Glu Phe Phe Glu 
 225                230                235                240
Ile Arg Asp Ala Pro Ser Asp Met Tyr Lys Ile Met Lys Lys Ala Ile 
                 245                250                255
Glu Arg Gly Ser Leu Met Gly Cys Ser Ile Asp Asp Gly Thr Asn Met 
             260                265                270
Thr Tyr Gly Thr Ser Pro Ser Gly Leu Asn Met Gly Glu Leu Ile Ala 
         275                280                285
Arg Met Val Arg Asn Met Asp Asn Ser Leu Leu Gln Asp Ser Asp Leu 
     290                295                300
Asp Pro Arg Gly Ser Asp Glu Arg Pro Thr Arg Thr Ile Ile Pro Val 
 305                310                315                320
Gln Tyr Glu Thr Arg Met Ala Cys Gly Leu Val Arg Gly His Ala Tyr 
                 325                330                335
Ser Val Thr Gly Leu Asp Glu Val Pro Phe Lys Gly Glu Lys Val Lys 
             340                345                350
Leu Val Arg Leu Arg Asn Pro Trp Gly Gln Val Glu Trp Asn Gly Ser 
         355                360                365
Trp Ser Asp Arg Trp Lys Asp Trp Ser Phe Val Asp Lys Asp Glu Lys 
     370                375                380
Ala Arg Leu Gln His Gln Val Thr Glu Asp Gly Glu Phe Trp Met Ser 
 385                390                395                400
Tyr Glu Asp Phe Ile Tyr His Phe Thr Lys Leu Glu Ile Cys Asn Leu 
                 405                410                415
Thr Ala Asp Ala Leu Gln Ser Asp Lys Leu Gln Thr Trp Thr Val Ser 
             420                425                430
Val Asn Glu Gly Arg Trp Val Arg Gly Cys Ser Ala Gly Gly Cys Arg 
         435                440                445
Asn Phe Pro Asp Thr Phe Trp Thr Asn Pro Gln Tyr Arg Leu Lys Leu 
     450                455                460
Leu Glu Glu Asp Asp Asp Pro Asp Asp Ser Glu Val Ile Cys Ser Phe 
 465                470                475                480
Leu Val Ala Leu Met Gln Lys Asn Arg Arg Lys Asp Arg Lys Leu Gly 
                 485                490                495
Ala Ser Leu Phe Thr Ile Gly Phe Ala Ile Tyr Glu Val Pro Lys Glu 
             500                505                510
Met His Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn 
         515                520                525
Ala Ser Lys Ala Arg Ser Lys Thr Tyr Ile Asn Met Arg Glu Val Ser 
     530                535                540
Gln Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Thr 
 545                550                555                560
Tyr Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu 
                 565                570                575
Lys Arg Asn Leu Ser Glu Glu Val Glu Asn Thr Ile Ser Val Asp Arg 
             580                585                590
Pro Val Lys Lys Lys Lys Thr Lys Pro Ile Ile Phe Val Ser Asp Arg 
         595                600                605
Ala Asn Ser Asn Lys Glu Leu Gly Val Asp Gln Glu Ser Glu Glu Gly 
     610                615                620
Lys Gly Lys Thr Ser Pro Asp Lys Gln Lys Gln Ser Pro Gln Pro Gln 
 625                630                635                640
Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu Gln Gln Gln Phe Arg Asn 
                 645                650                655
Ile Phe Lys Gln Ile Ala Gly Asp Asp Met Glu Ile Cys Ala Asp Glu 
             660                665                670
Leu Lys Lys Val Leu Asn Thr Val Val Asn Lys His Lys Asp Leu Lys 
         675                680                685
Thr His Gly Phe Thr Leu Glu Ser Cys Arg Ser Met Ile Ala Leu Met 
     690                695                700
Asp Thr Asp Gly Ser Gly Lys Leu Asn Leu Gln Glu Phe His His Leu 
 705                710                715                720
Trp Asn Lys Ile Lys Ala Trp Gln Lys Ile Phe Lys His Tyr Asp Thr 
                 725                730                735
Asp Gln Ser Gly Thr Ile Asn Ser Tyr Glu Met Arg Asn Ala Val Asn 
             740                745                750
Asp Ala Gly Phe His Leu Asn Asn Gln Leu Tyr Asp Ile Ile Thr Met 
         755                760                765
Arg Tyr Ala Asp Lys His Met Asn Ile Asp Phe Asp Ser Phe Ile Cys 
     770                775                780
Cys Phe Val Arg Leu Glu Gly Met Phe Arg Ala Phe His Ala Phe Asp 
 785                790                795                800
Lys Asp Gly Asp Gly Ile Ile Lys Leu Asn Val Leu Glu Trp Leu Gln 
                 805                810                815
Leu Thr Met Tyr Ala 
             820



<210> 928
<211> 7272
<212> DNA
<213> Rattus norvegicus
<308> AF061947
<400> 928

ggccgcctc  gaggtccgt  cagggctcc  gtgagcgcg  ggaggtggg  acacgcgac  60
cccgctctc  attacgggc  cggtgggcc  aagcctggc  cgagacccg  aggcgctga  120
aaggacctt  tggccacgc  tgctcctcc  cgcgccccg  cgctgcgcc  ggaggcgcc  180
agggtgggt  actgggacc  cagctcgaa  ccatccctt  ctgtgcgtc  tttcattca  240
cttcacagc  gcccagaga  ggactgtca  ctggcacat  ccccaccag  gatgggaag  300
gatcctcca  ggtggcgct  aatctctga  tatgattcg  attgcagcc  taaatgcca  360
ctccacaat  gaagatgac  atgaaggaa  ctttaaaag  cacaaaatc  agacaaagg  420
ggctcagga  gcagaagcc  ttgccctat  ccacaaggc  ctggatctg  agaaacatg  480
caggtttga  gagtctgcc  aggcctacc  tgaactcct  gaggctcgc  tgctgcgag  540
ggcagtttc  tccggagat  agaaggaag  gctgaagca  cctggactg  tactgaaat  600
ttctacgta  aagaacctg  cccagctgg  agcccagcg  gaggacctg  agacagcca  660
ggagtttta  ttggaggcc  tgatgctgg  ttccacaga  gtcaacctt  ggtacaaga  720
tggacatgt  gccctgagg  tcatccggc  tcccctggc  cgccatgct  ttgaggaag  780
gctccggtg  aatcctgac  actggccct  cttggacaa  ctcatcact  ttttgtaca  840
cctcagcga  tacacaaca  gtctttact  catctgcaa  gcactggag  aagactgcc  900
ctacagcaa  ggcctggtt  tcaaggaga  gatttttga  gagcaacct  gtctccgaa  960
ggactcact  cgaatgttc  tcaaatgtg  catgtcagt  cacgaggtg  cagtgaatg  1020
agcagagac  caggccatt  tagacgagg  tctggggct  cggaagaag  ggcaggcgt  1080
gatcgtgcg  gaaaaggag  cagacctga  actagtgca  cccatccct  tcttcacgt  1140
gaagtgcct  ggagagagc  tgcttgcca  gtacaatca  ctcaccacg  gtgagcctc  1200
caggcccag  ctgggcaag  ggattgacc  gtctgacta  caggatccc  gccagctgc  1260
tgccccctc  atcgtggtt  ctcctgtca  tgtggtcca  ccaagtcct  tttgcacca  1320
tccaactgt  gctgtggcc  agcctgtgc  ctcctacac  tctgtgacc  caaccagct  1380
cccactgca  agtcctggc  tgctggaca  gggcactcc  atgggtgat  tttccggag  1440
agataaatc  aaaaaaggg  tgaagcgta  gaagacttt  gaggaaagt  gggagacag  1500
aaagcggag  tctgcccgt  tccgcaaca  caagtgcaa  aaagaagag  aggtggatt  1560
ccaggggct  ctggtaaag  tcctgccgt  caggttaag  aaactggac  ctgaggagg  1620
agatgatcc  tttaacaac  atgaagttc  gtcagaagc  aaactggag  gcttctcga  1680
cgtgggacc  catcgactg  ccttcgatt  agccacatt  atggaatct  agaagcagg  1740
tgtgcatgc  ttcctgatg  agaacctga  caatggggg  gtcctggag  tcatgatgc  1800
ctacctgaa  agcatgggc  acaagttcc  gctgaagtg  cccccaggc  tggcggagg  1860
cgtacttag  gtctaccac  gctggagga  gcacagtac  agcctgccc  acccattgc  1920
gagggactg  agcaacaag  acatcaagg  catgatgct  atgtctctt  cctgcatgg  1980
gctccaact  gaccagtgg  ttctgacca  aggcagaag  tccacggtg  ctccccgga  2040
ctgccctgc  ggtgtggtg  caggcaggt  tgggccaga  ttcccagga  cccactgcc  2100
gggtgacct  ctgcagctg  catttgcgt  atctcagcg  gatctgttt  aggacggct  2160
gctggagtt  gtggtccgt  tttactggc  gaaggcacg  ttcttggca  tacagggcg  2220
tatggagca  gctttggag  actatgata  ctgcacaga  atactccag  gctccacgg  2280
tctccaagc  caggcaggg  ctgagcaaa  ggacattgt  atccggctg  ccaacctgc  2340
caatgactc  attgtttct  tggaggaaa  tgataagaa  ctgaagtct  tggaaaggt  2400
ccagtccct  gaggagatt  agcggctgt  tgaggcggg  gactacaag  ccgtggtgc  2460
gctgctccg  cccactctg  gcaccagtg  ctttgaccg  gccaaacac  tggagttta  2520
gacttccat  cccgagagg  cggcccagc  gcttctgct  caggactct  tgctccggc  2580
ggaggagca  aggcagtgc  ttgaatgct  tgacgtggc  ctcaatgaa  ctgtccagc  2640
gatgctgaa  tcgagtgac  ctgcggcca  ggaggagtg  gcggccaca  tgacgcagc  2700
gctgctagg  atggagcag  cactgtcat  agacagcag  ggcagcatc  tgaaggagt  2760
ctcctctcc  acgggcctt  tccggctca  caacaacct  attcaggtc  tcgactgca  2820
catggctgt  caggaggag  ccaaggagc  ctatgtctc  tccgtgctg  cctggatca  2880
cctccacag  atcatctgg  aggaggaag  cactttccg  tctctgtgc  accagcagc  2940
gctccagaa  ccaacggaa  aagggatct  ggagatgcc  atgctccca  cttccctca  3000
gctgctcaa  acagcacat  agtacctgg  caggaggtc  tggtgctgc  attcagatg  3060
agcgctgct  cgattctat  tgcacgttc  ccaaaagga  cttgctgcg  ctgcctctg  3120
ggacactca  ccctacaag  aggagctgg  gaccgcctt  gagcagtgt  tctactgcc  3180
ctacagctt  cccagcaag  agagcaagg  caggtacct  gaggagcac  cagcccagc  3240
ggtggacct  acctgggag  acgccctgt  catgtttga  tacttcaag  ccaagaccc  3300
ccctgagtt  gacagctac  agaccagca  cgtctctgc  gacttggca  acctgttga  3360
aagaatcgc  accattgtg  cgcgcacag  gaagcccgc  ctgagcatg  acaaagtct  3420
tgcctacat  gagggaacc  cagcggagg  gccctgcct  cctgacggg  cagaccccg  3480
ccctccagt  ctgaatgag  tctactacc  cctggctga  tatcacttc  aaaacaaag  3540
gcagtccaa  gccatcaag  tctacatgc  tgacatttg  atctgccct  acaggtttg  3600
ttcctgggc  ggcatggct  tggcccggg  cagccgaat  caggacaag  tgaactcaa  3660
tgagctgaa  agtgatgga  ccatctgga  acatgccac  cctgttctg  actgcttcc  3720
gagggccct  gagattgac  gctctaact  gtccttgtg  attgagtat  gcaccatgt  3780
ctatgcctt  cactcattc  cgtcccgtc  gctgaagca  tggcgagcc  agctgcctc  3840
tgaggttgt  cagcagatg  aggatcggc  agacagcat  ctggagaca  ccaggcact  3900
tttcacgtc  gcagcccac  gcgagggtg  tggcgatga  gaggagtgg  tcattcact  3960
catgctggg  aaagtggca  agaagcagc  gcagccgcc  accgtgtac  tgctgcact  4020
ccgtcaggc  ggccactac  tacacgagg  ggccgcccg  taccctaag  agattcact  4080
ccacaaccc  cccgagctg  ccatggaag  cctggaggt  tacttccgg  tccatgcgt  4140
catcctgaa  ctcctgggc  aacctgact  tggggttag  gcagaggtc  tggtcagct  4200
tatgaagga  gcagcagaa  gaccttttg  caggggcga  gagaagaat  cacctaaag  4260
ttcagaaaa  gagaaggcc  gcctggtgg  tgaggactc  cactcttca  ctgggacac  4320
gccgggccc  ggagcctcc  ttccctcct  ctctggccc  ggtctgaca  ccccacctt  4380
cacagccac  ccgattgac  acgattacg  caaatgtaa  aaaccccgt  agcaggcga  4440
gccggacga  cgaagccag  acagcacag  tgtggcact  tcagactcc  gctcaacac  4500
ggacttctt  aatgagccc  caagtttgc  ggacggttc  cgaaagctc  ttccagaga  4560
gaggatctc  gggctcagt  ctcaagcag  accaagtgg  aaagacctt  cagggccca  4620
agaggaaag  ggaaaaacg  aggagtctt  ggagagcac  gaggccttc  gggttgtag  4680
accaagcgt  cagaagcct  tggcagatt  ctcggcctc  gcttacatc  ccagcaagc  4740
cgcagtgtc  acgccccct  cgtgggatg  gaagaagag  agtgacccc  taggggagc  4800
agtggcttt  cctcagggg  tgccagcag  tgctgagga  cagcgccag  tcctcacag  4860
gcagtgcat  gcctccttc  gcctgtgct  gagtcgctt  ccacagcac  acaagagtc  4920
ctaccggct  gcctttctc  acacctaca  caagactca  cggaacctc  agtgggccc  4980
tgatgtgtt  ctaggcagc  gtatcccat  gcaacaact  cagcacatg  cggcacagg  5040
gctcttctg  gagaggaac  agaccaatt  cttcaacgg  atctggcgg  tccccgtgg  5100
tgagattga  cggcccggc  gcttcgcct  gcacatgaa  cgctccatc  tgctgctac  5160
caaggttct  gcccagctc  gggaccaca  caccctgtt  aaggtgtcc  ccatgctgc  5220
gcggacacc  gaccagggc  agaaatatc  gcgagatgc  gaccgccag  tgctggcac  5280
gcgcgcctt  atcctcact  tgaaggtgc  ggaggacac  ctgagtgag  ttgcagagg  5340
gttagagca  ccaggatcc  aggcctgtg  cctctctgg  gccaggatg  ccaccgatg  5400
ctcacacaa  gccagtccc  aggatggcc  ggaaagcct  ccacacccc  agaagctac  5460
tctagctga  ggctcagga  cagggcctg  gccaggggg  aaagtgggc  ctctccacc  5520
attgccagt  gccacagac  caagggaca  cacagagca  ggtggggag  cgaaagaca  5580
agagcgtcc  ccggtgggg  ccacagaac  catggacac  ggcgagact  ctgctcgcc  5640
cccagactt  gaaccgacg  cacgtctgt  gccaggccg  cccccaagg  accggggtc  5700
cgagagccg  tctgctgag  tttccctgg  ggagctgag  atcagcacc  ggcagcagc  5760
tgccccact  gtaccatcc  cagtaaccc  caccacagc  gctcccact  ccatggggg  5820
cagggcagc  gggcacccc  aggaggcac  gccaaggcc  aatcgaaag  ggaaactcc  5880
gcaggacac  gagtctggc  agacgctcc  tttggacgc  taccgtgtg  ggcagcagg  5940
ccagaaggc  atggcctat  acctgagcc  catcgagaa  atcatgtcg  agacttaca  6000
gctcatcaa  caggtggac  aggagactg  actggagca  gctgtgaag  tctgtcagg  6060
ccacctcgg  gctgctgcc  agagacagg  ctcaggaga  gcacccact  cccccaagc  6120
ccccaagga  agccgagag  atttcttcc  tgcaacagt  gccccctca  cacctgaca  6180
cacagcacc  gacgctctc  agcggccca  tgactccca  ctcaagcct  ggttggctg  6240
tgccatcac  tgccctccc  cagcatcag  ctctacccc  gaccctgga  ttccccagc  6300
acacaggcc  gaggctgtg  ccagcaggg  ccctctgag  cctgatgga  aagaggtgt  6360
aggagtgac  gagggtccc  gctttctat  ccaagaacc  cggcacagt  accagatga  6420
aatggctgc  actggtccc  tggccgagc  gcactgctg  ccagtggag  ctgcttgcc  6480
gacaggtgc  gagcccacc  tcagccaag  caccagcac  aaggtcccc  gcagtggaa  6540
tacccagac  cctgagagc  atcaaggca  aactgagtc  agcagagcc  agtcccgcc  6600
cctgcccaa  atgccaaag  tggtgatcc  ctcggccac  accaagttc  cccctgaga  6660
caccgtcac  ccacctacc  ccaccctgc  ctcccccaa  ggcagcatc  cagaggaga  6720
caagcagaa  ctgaagtct  ccatcctgt  tgcccaatc  gccgccaat  tgaggaagg  6780
gagcctgtg  cagccagcc  tggaggttc  ggagacatc  agccaggag  cctcattgg  6840
gagtgagac  gacgaggac  atgacttta  ggacgtatg  cgggttcac  cagaggcag  6900
gcctggggt  cctttggtc  agaccctgg  caaggccag  agcctattg  ggtatggtt  6960
cctgtggtc  cctaagcct  cccagcccc  tctttgcag  accctgccc  ggctcaggc  7020
gtccagagc  tgctggtcc  gaggacggt  cggcctgtc  taggcacat  cactgctgc  7080
gtctgcaca  ccgggatgc  gccgccgcc  ccgcttctt  ttttaatga  atactgact  7140
tctctacaa  cccgtgtgt  ctgaccagg  ccacagtcc  gtgccgagg  gacatcagg  7200
gcctagctc  ccccacacc  tttttygtc  ttgttgctt  tttttctaa  aaagatgga  7260
aatggtaaa  aa  7272



<210> 929
<211> 2182
<212> PRT
<213> Rattus norvegicus
<308> O88480
<400> 929

Met Ile Arg Ile Ala Ala Leu Asn Ala Ser Ser Thr Ile Glu Asp Asp 
  1               5                  10                  15
His Glu Gly Ser Phe Lys Ser His Lys Ile Gln Thr Lys Glu Ala Gln 
             20                  25                  30
Glu Ala Glu Ala Phe Ala Leu Tyr His Lys Ala Leu Asp Leu Gln Lys 
         35                  40                  45
His Asp Arg Phe Glu Glu Ser Ala Lys Ala Tyr His Glu Leu Leu Glu 
     50                  55                  60
Ala Arg Leu Leu Arg Glu Ala Val Ser Ser Gly Asp Glu Lys Glu Gly 
 65                  70                  75                  80
Leu Lys His Pro Gly Leu Ile Leu Lys Tyr Ser Thr Tyr Lys Asn Leu 
                 85                  90                  95
Ala Gln Leu Ala Ala Gln Arg Glu Asp Leu Glu Thr Ala Met Glu Phe 
             100                105                110
Tyr Leu Glu Ala Val Met Leu Asp Ser Thr Asp Val Asn Leu Trp Tyr 
         115                120                125
Lys Ile Gly His Val Ala Leu Arg Leu Ile Arg Leu Pro Leu Ala Arg 
     130                135                140
His Ala Phe Glu Glu Gly Leu Arg Cys Asn Pro Asp His Trp Pro Cys 
 145                150                155                160
Leu Asp Asn Leu Ile Thr Val Leu Tyr Thr Leu Ser Asp Tyr Thr Thr 
                 165                170                175
Cys Leu Tyr Phe Ile Cys Lys Ala Leu Glu Lys Asp Cys Arg Tyr Ser 
             180                185                190
Lys Gly Leu Val Leu Lys Glu Lys Ile Phe Glu Glu Gln Pro Cys Leu 
         195                200                205
Arg Lys Asp Ser Leu Arg Met Phe Leu Lys Cys Asp Met Ser Val His 
     210                215                220
Glu Val Ser Val Asn Ala Ala Glu Thr Gln Ala Ile Val Asp Glu Ala 
 225                230                235                240
Leu Gly Leu Arg Lys Lys Arg Gln Ala Leu Ile Val Arg Glu Lys Glu 
                 245                250                255
Pro Asp Leu Lys Leu Val Gln Pro Ile Pro Phe Phe Thr Trp Lys Cys 
             260                265                270
Leu Gly Glu Ser Leu Leu Ala Met Tyr Asn His Leu Thr Thr Cys Glu 
         275                280                285
Pro Pro Arg Pro Ser Leu Gly Lys Arg Ile Asp Leu Ser Asp Tyr Gln 
     290                295                300
Asp Pro Ser Gln Leu Leu Ala Pro Ser Ile Val Val Thr Pro Val Ser 
 305                310                315                320
Val Val Gln Pro Ser Pro Val Cys Thr Asn Pro Thr Val Ala Val Ala 
                 325                330                335
Glu Pro Val Leu Ser Tyr Thr Ser Val Thr Thr Thr Ser Phe Pro Leu 
             340                345                350
His Ser Pro Gly Leu Leu Asp Thr Gly Thr Pro Met Gly Asp Val Ser 
         355                360                365
Gly Gly Asp Lys Ser Lys Lys Gly Val Lys Arg Lys Lys Thr Leu Glu 
     370                375                380
Glu Ser Gly Glu Thr Ala Lys Arg Arg Ser Ala Arg Val Arg Asn Thr 
 385                390                395                400
Lys Cys Lys Lys Glu Glu Lys Val Asp Phe Gln Gly Leu Leu Val Lys 
                 405                410                415
Phe Leu Pro Ser Arg Leu Arg Lys Leu Asp Pro Glu Glu Glu Asp Asp 
             420                425                430
Pro Phe Asn Asn Tyr Glu Val Gln Ser Glu Ala Lys Leu Glu Ser Phe 
         435                440                445
Ser Asn Val Gly Pro His Arg Leu Ser Phe Asp Ser Ala Thr Phe Met 
     450                455                460
Glu Ser Glu Lys Gln Asp Val His Ala Phe Leu Met Glu Asn Leu Thr 
 465                470                475                480
Asn Gly Gly Val Leu Glu Leu Met Met Arg Tyr Leu Lys Ser Met Gly 
                 485                490                495
His Lys Phe Leu Leu Lys Trp Pro Pro Gly Leu Ala Glu Val Val Leu 
             500                505                510
Ser Val Tyr His Ser Trp Arg Arg His Ser Thr Ser Leu Pro Asn Pro 
         515                520                525
Leu Leu Arg Asp Cys Ser Asn Lys His Ile Lys Asp Met Met Leu Met 
     530                535                540
Ser Leu Ser Cys Met Glu Leu Gln Leu Asp Gln Trp Leu Leu Thr Lys 
 545                550                555                560
Gly Arg Ser Ser Thr Val Ser Pro Arg Asn Cys Pro Ala Gly Val Val 
                 565                570                575
Thr Gly Arg Phe Gly Pro Asp Phe Pro Gly Thr His Cys Leu Gly Asp 
             580                585                590
Leu Leu Gln Leu Ser Phe Ala Ser Ser Gln Arg Asp Leu Phe Glu Asp 
         595                600                605
Gly Trp Leu Glu Phe Val Val Arg Val Tyr Trp Leu Lys Ala Arg Phe 
     610                615                620
Leu Ala Leu Gln Gly Asp Met Glu Gln Ala Leu Glu Asn Tyr Asp Ile 
 625                630                635                640
Cys Thr Glu Ile Leu Gln Ser Ser Thr Ala Leu Gln Ala Gln Ala Gly 
                 645                650                655
Ala Glu Gln Arg Asp Ile Val Ile Arg Leu Pro Asn Leu His Asn Asp 
             660                665                670
Ser Ile Val Ser Leu Glu Glu Ile Asp Lys Asn Leu Lys Ser Leu Glu 
         675                680                685
Arg Cys Gln Ser Leu Glu Glu Ile Gln Arg Leu Phe Glu Ala Gly Asp 
     690                695                700
Tyr Lys Ala Val Val Gln Leu Leu Arg Pro Thr Leu Cys Thr Ser Gly 
 705                710                715                720
Phe Asp Arg Ala Lys His Leu Glu Phe Met Thr Ser Ile Pro Glu Arg 
                 725                730                735
Pro Ala Gln Leu Leu Leu Leu Gln Asp Ser Leu Leu Arg Leu Glu Glu 
             740                745                750
His Arg Gln Cys Phe Glu Cys Ser Asp Val Ala Leu Asn Glu Ala Val 
         755                760                765
Gln Gln Met Leu Asn Ser Ser Asp Ser Ala Ala Lys Glu Glu Trp Ala 
     770                775                780
Ala Thr Val Thr Gln Leu Leu Leu Gly Met Glu Gln Ala Leu Ser Ser 
 785                790                795                800
Asp Ser Arg Gly Ser Ile Leu Lys Glu Ser Ser Ser Pro Thr Gly Leu 
                 805                810                815
Val Arg Leu Thr Asn Asn Leu Ile Gln Val Ile Asp Cys Ser Met Ala 
             820                825                830
Val Gln Glu Glu Pro Lys Glu Pro Tyr Val Ser Ser Val Leu Pro Trp 
         835                840                845
Ile Ile Leu His Arg Ile Ile Trp Gln Glu Glu Asp Thr Phe Arg Ser 
     850                855                860
Leu Cys His Gln Gln Gln Leu Gln Asn Pro Thr Glu Glu Gly Ile Ser 
 865                870                875                880
Glu Met Pro Met Leu Pro Ser Ser Leu Met Leu Leu Asn Thr Ala His 
                 885                890                895
Glu Tyr Leu Gly Arg Arg Ser Trp Cys Cys Asn Ser Asp Gly Ala Leu 
             900                905                910
Leu Arg Phe Tyr Val His Val Leu Gln Lys Glu Leu Ala Ala Ser Ala 
         915                920                925
Ser Glu Asp Thr His Pro Tyr Lys Glu Glu Leu Glu Thr Ala Leu Glu 
     930                935                940
Gln Cys Phe Tyr Cys Leu Tyr Ser Phe Pro Ser Lys Lys Ser Lys Ala 
 945                950                955                960
Arg Tyr Leu Glu Glu His Ser Ala Gln Gln Val Asp Leu Thr Trp Glu 
                 965                970                975
Asp Ala Leu Phe Met Phe Glu Tyr Phe Lys Pro Lys Thr Leu Pro Glu 
             980                985                990
Phe Asp Ser Tyr Lys Thr Ser Thr Val Ser Ala Asp Leu Ala Asn Leu 
         995                1000                1005
Leu Lys Arg Ile Ala Thr Ile Val Pro Arg Thr Glu Lys Pro Ala Leu 
     1010                1015                1020
Ser Met Asp Lys Val Ser Ala Tyr Ile Glu Gly Thr Ser Ala Glu Val 
 1025                1030                1035                1040
Pro Cys Leu Pro Asp Gly Ala Asp Pro Ala Pro Pro Val Leu Asn Glu 
                 1045                1050                1055
Leu Tyr Tyr Leu Leu Ala Asp Tyr His Phe Lys Asn Lys Glu Gln Ser 
             1060                1065                1070
Lys Ala Ile Lys Phe Tyr Met His Asp Ile Cys Ile Cys Pro Asn Arg 
         1075                1080                1085
Phe Asp Ser Trp Ala Gly Met Ala Leu Ala Arg Ala Ser Arg Ile Gln 
     1090                1095                1100
Asp Lys Leu Asn Ser Asn Glu Leu Lys Ser Asp Gly Pro Ile Trp Arg 
 1105                1110                1115                1120
His Ala Thr Pro Val Leu Asn Cys Phe Arg Arg Ala Leu Glu Ile Asp 
                 1125                1130                1135
Ser Ser Asn Leu Ser Leu Trp Ile Glu Tyr Gly Thr Met Ser Tyr Ala 
             1140                1145                1150
Leu His Ser Phe Ala Ser Arg Gln Leu Lys Gln Trp Arg Ala Glu Leu 
         1155                1160                1165
Pro Pro Glu Val Val Gln Gln Met Glu Asp Arg Arg Asp Ser Met Leu 
     1170                1175                1180
Glu Thr Ala Arg His Cys Phe Thr Ser Ala Ala His Cys Glu Gly Asp 
 1185                1190                1195                1200
Gly Asp Glu Glu Glu Trp Leu Ile His Tyr Met Leu Gly Lys Val Ala 
                 1205                1210                1215
Glu Lys Gln Gln Gln Pro Pro Thr Val Tyr Leu Leu His Tyr Arg Gln 
             1220                1225                1230
Ala Gly His Tyr Leu His Glu Glu Ala Ala Arg Tyr Pro Lys Lys Ile 
         1235                1240                1245
His Tyr His Asn Pro Pro Glu Leu Ala Met Glu Ala Leu Glu Val Tyr 
     1250                1255                1260
Phe Arg Leu His Ala Ser Ile Leu Lys Leu Leu Gly Lys Pro Asp Ser 
 1265                1270                1275                1280
Gly Val Ser Ala Glu Val Leu Val Ser Phe Met Lys Glu Ala Ala Glu 
                 1285                1290                1295
Gly Pro Phe Ala Arg Gly Glu Glu Lys Asn Thr Pro Lys Ala Ser Glu 
             1300                1305                1310
Lys Glu Lys Ala Cys Leu Val Asp Glu Asp Ser His Ser Ser Ala Gly 
         1315                1320                1325
Thr Leu Pro Gly Pro Gly Ala Ser Leu Pro Ser Ser Ser Gly Pro Gly 
     1330                1335                1340
Leu Thr Ser Pro Pro Tyr Thr Ala Thr Pro Ile Asp His Asp Tyr Val 
 1345                1350                1355                1360
Lys Cys Lys Lys Pro Arg Gln Gln Ala Thr Pro Asp Asp Arg Ser Gln 
                 1365                1370                1375
Asp Ser Thr Ala Val Ala Leu Ser Asp Ser Ser Ser Thr Gln Asp Phe 
             1380                1385                1390
Phe Asn Glu Pro Thr Ser Leu Leu Asp Gly Ser Arg Lys Leu Leu Pro 
         1395                1400                1405
Glu Lys Arg Ile Ser Gly Leu Ser Ala Gln Ala Gly Pro Ser Gly Lys 
     1410                1415                1420
Asp Leu Pro Gly Pro Thr Glu Glu Arg Gly Lys Thr Glu Glu Ser Leu 
 1425                1430                1435                1440
Glu Ser Thr Glu Ala Phe Arg Val Val Glu Pro Ser Val Gln Lys Pro 
                 1445                1450                1455
Val Ala Asp Ser Ser Ala Ser Ala Tyr Ile Pro Ser Lys Pro Ala Val 
             1460                1465                1470
Ser Thr Pro Pro Pro Trp Asp Gly Lys Lys Arg Ser Asp Pro Leu Gly 
         1475                1480                1485
Glu Pro Val Ala Phe Pro Gln Gly Leu Pro Ala Gly Ala Glu Glu Gln 
     1490                1495                1500
Arg Gln Phe Leu Thr Glu Gln Cys Ile Ala Ser Phe Cys Leu Cys Leu 
 1505                1510                1515                1520
Ser Arg Phe Pro Gln His Tyr Lys Ser Leu Tyr Arg Leu Ala Phe Leu 
                 1525                1530                1535
Tyr Thr Tyr Ser Lys Thr His Arg Asn Leu Gln Trp Ala Arg Asp Val 
             1540                1545                1550
Leu Leu Gly Ser Ser Ile Pro Trp Gln Gln Leu Gln His Met Pro Ala 
         1555                1560                1565
Gln Gly Leu Phe Cys Glu Arg Asn Lys Thr Asn Phe Phe Asn Gly Ile 
     1570                1575                1580
Trp Arg Ile Pro Val Asp Glu Ile Asp Arg Pro Gly Ser Phe Ala Trp 
 1585                1590                1595                1600
His Met Asn Arg Ser Ile Val Leu Leu Leu Lys Val Leu Ala Gln Leu 
                 1605                1610                1615
Arg Asp His Ser Thr Leu Leu Lys Val Ser Ser Met Leu Gln Arg Thr 
             1620                1625                1630
Pro Asp Gln Gly Lys Lys Tyr Leu Arg Asp Ala Asp Arg Gln Val Leu 
         1635                1640                1645
Ala Gln Arg Ala Phe Ile Leu Thr Val Lys Val Leu Glu Asp Thr Leu 
     1650                1655                1660
Ser Glu Leu Ala Glu Gly Leu Glu His Pro Gly Ser Lys Ala Cys Gly 
 1665                1670                1675                1680
Leu Ser Gly Ala Arg Met Thr Thr Asp Val Ser His Lys Ala Ser Pro 
                 1685                1690                1695
Glu Asp Gly Gln Glu Ser Leu Pro His Pro Lys Lys Leu Pro Leu Ala 
             1700                1705                1710
Asp Gly Ser Gly Pro Gly Pro Glu Pro Gly Gly Lys Val Gly Pro Leu 
         1715                1720                1725
His Gln Leu Pro Val Ala Thr Asp Thr Arg Asp Asn Thr Glu Gln Gly 
     1730                1735                1740
Gly Glu Pro Lys Asp Lys Glu Arg Pro Pro Val Gly Pro Thr Glu Pro 
 1745                1750                1755                1760
Met Asp Thr Gly Glu Thr Ala Ala Arg His Pro Asp Leu Glu Pro Thr 
                 1765                1770                1775
Pro Arg Leu Leu Pro Gly Arg Pro Pro Arg Asp Arg Gly Pro Glu Ser 
             1780                1785                1790
Arg Ser Ala Glu Leu Ser Leu Glu Glu Leu Ser Ile Ser Thr Arg Gln 
         1795                1800                1805
Gln Pro Ala Pro Leu Val Pro Ser Pro Val Thr Pro Thr Thr Ala Ala 
     1810                1815                1820
Pro Thr Thr Met Gly Ala Arg Ala Ala Gly His Pro Glu Glu Ala Pro 
 1825                1830                1835                1840
Pro Arg Pro Asn Arg Lys Arg Lys Leu Leu Gln Asp Thr Glu Ser Gly 
                 1845                1850                1855
Lys Thr Leu Leu Leu Asp Ala Tyr Arg Val Trp Gln Gln Gly Gln Lys 
             1860                1865                1870
Ala Met Ala Tyr Asp Leu Ser Arg Ile Glu Lys Ile Met Ser Glu Thr 
         1875                1880                1885
Tyr Met Leu Ile Lys Gln Val Asp Glu Glu Thr Ala Leu Glu Gln Ala 
     1890                1895                1900
Val Lys Phe Cys Gln Val His Leu Gly Ala Ala Ala Gln Arg Gln Ala 
 1905                1910                1915                1920
Ser Gly Asp Ala Pro Thr Thr Pro Lys His Pro Lys Asp Ser Arg Glu 
                 1925                1930                1935
Asn Phe Phe Pro Ala Thr Val Ala Pro Ser Ala Pro Asp Thr Thr Ala 
             1940                1945                1950
Pro Asp Ala Leu Gln Arg Pro Ser Asp Ser His Leu Lys Pro Gly Leu 
         1955                1960                1965
Ala Ala Ala Ile Thr Cys Pro Pro Ser Ala Ser Ala Ser Thr Pro Asp 
     1970                1975                1980
Pro Gly Ile Pro Gln Pro His Arg Pro Glu Ala Val Pro Ser Arg Ala 
 1985                1990                1995                2000
Pro Leu Ser Pro Asp Gly Glu Glu Val Ser Gly Val Thr Glu Gly Pro 
                 2005                2010                2015
Ser Phe Leu Ser Gln Glu Pro Arg His Ser His Gln Met Lys Met Ala 
             2020                2025                2030
Ala Thr Gly Pro Leu Ala Glu Gln His Cys Trp Pro Val Glu Ala Ala 
         2035                2040                2045
Cys Gln Thr Gly Ala Glu Pro Thr Phe Ser Gln Ala Thr Ser Thr Lys 
     2050                2055                2060
Val Pro Ser Ser Gly Ser Thr Gln Thr Pro Glu Ser His Gln Gly Lys 
 2065                2070                2075                2080
Thr Glu Ser Ser Arg Ala Lys Ser Arg Leu Leu Pro Asn Met Pro Lys 
                 2085                2090                2095
Leu Val Ile Pro Ser Ala Thr Thr Lys Phe Pro Pro Glu Ile Thr Val 
             2100                2105                2110
Thr Pro Pro Thr Pro Thr Leu Leu Ser Pro Lys Gly Ser Ile Ser Glu 
         2115                2120                2125
Glu Thr Lys Gln Lys Leu Lys Ser Ala Ile Leu Ser Ala Gln Ser Ala 
     2130                2135                2140
Ala Asn Val Arg Lys Glu Ser Leu Cys Gln Pro Ala Leu Glu Val Leu 
 2145                2150                2155                2160
Glu Thr Ser Ser Gln Glu Ser Ser Leu Glu Ser Glu Thr Asp Glu Asp 
                 2165                2170                2175
Asp Asp Phe Met Asp Val 
             2180



<210> 930
<211> 6143
<212> DNA
<213> Homo sapiens
<308> AB002328
<400> 930

cagttaacg  gatccagcc  agcactgtc  gcaccaacc  agctgtggc  gtcgccgag  60
ctgtggtct  ctacacctc  gtggctaca  ccagcttcc  actgcacag  cctggtctg  120
tggagacag  cgctcctgt  ggtgatatt  ctgggggag  taaatccaa  aaaggggta  180
aacggaaga  gatttcaga  gagagtgga  aaacagcaa  gcggcggtc  gcccgtgtc  240
gaaacacca  gtgcaaaaa  gaagagaaa  tagacttcc  ggagcttct  atgaagttc  300
tgccgtcca  gttaagaaa  ctggaccct  aggaggaag  tgattcctt  aataactat  360
aagtccagt  agaagccaa  ctggaaagc  tcccaagca  tgggcctca  aggctgtca  420
ttgactcag  cacattcat  gaatctgaa  agcaggacg  gcatgagtt  ctgctggag  480
acctaacca  cgggggcat  ctggagctg  tgatgcgct  cctgaaagc  atgggccac  540
agttcttgg  aaggtggcc  ccaggcttg  cggaggtcg  gctcagcgt  taccacagc  600
ggaggaggc  cagcaccag  ctgcccaac  cgctgctga  ggactgcag  aacaagcac  660
tcaaggaca  gatgctgat  tctctctcc  gcatggaac  ccagctgga  cagtggctg  720
tgaccaaag  cagaagctc  gcagtgtct  ctcggaact  ccctgctgg  atggtgaat  780
gcagatttg  acctgactt  ccagggacc  actgcctgg  tgacctcct  cagctgtca  840
ttgcctcgt  ccagcgcga  ctgttcgag  atggttggc  ggagtttgt  gtccgtgtt  900
actggctga  ggctcgctt  ctggcgctg  agggagaca  ggagcaggc  ctggagaac  960
atgacatct  cacagaaat  ctccagagt  ccaccgcca  ccaggtgga  gcaggggct  1020
aacgaagag  cattgtcat  cggctgccc  acctccata  tgactctgt  gtttccctg  1080
aggagattg  taagaacct  aagtcgctg  agcggtgcc  gtccctgga  gagattcag  1140
ggctgtatg  agcaggcga  tacaaggct  ttgtgcatc  gctccgccc  actttgtgc  1200
ccagtgggt  tgaccgggc  aaacacctg  agtttatga  ttccattcc  gagaggcca  1260
cccagctgc  tcttctgca  gactccttg  tccggctga  ggactatcg  cagtgtttt  1320
agtgttccg  tgtggctct  aacgaggct  tccagcaga  ggtgaactc  ggtgaggct  1380
ccgccaagg  ggagtgggt  gccacagtg  cccaactgc  gatgggcat  gagcaggcc  1440
tctctgcgg  cagcagtgg  agcatcctg  aggtatcat  ctccaccac  ggccttgtg  1500
ggctcacca  caacctcat  caggtcatt  actgcagca  ggctgtgca  gaggaggcc  1560
aggagcccc  cgtctcttc  gtgctaccc  ggatcattc  acaccggat  atctggcag  1620
aggaagaca  cttccattc  ctgtgccac  agcagcagc  ccaaaaccc  gcggaggaa  1680
ggatgtcag  gacgcccat  ctcccatcc  ccctcatgc  gctgaacac  gcccacgag  1740
atttgggca  aaggtcctg  tgctgcaat  cagatgggg  tctgctgcg  ttctatgtg  1800
gagtactcc  gaaggaact  gctgcatcc  cctctgaag  cacgcaccc  tacaaggag  1860
agctggaga  agccttgga  cagtgcttc  actgcctgt  cagcttccc  agcaagaag  1920
gtaaggcca  gtacctgga  gaacactcg  cccagcagg  ggatcttat  tgggaggat  1980
cactgttca  gtttgagta  tttaagccc  agacccttc  tgaatttga  agctataag  2040
ccagcaccg  gtctgctga  ttggccaac  tactgaaga  aattgccac  attgtgcct  2100
gcacagaga  gccagccct  agcctggac  aagtctctg  ctacattga  ggaacttca  2160
ctgaggtac  ctgcctccc  gagggggct  acccctccc  tccagtggt  aacgagctt  2220
actacctcc  ggctgatta  catttcaaa  acaaggagc  gtccaaggc  atcaagttc  2280
acatgcatg  catctgcat  tgccccaat  ggtttgatt  ctgggcagg  atggctctg  2340
cccgggcca  ccgcattca  gacaagctg  actccaatg  gctgaagag  gatgggccc  2400
tttggaagc  tgccacgcc  gtcttgaac  gcttccgtc  ggccctgga  attgacagc  2460
ccaacttgt  cctatggat  gagtatggc  ccatgtcct  tgccttgca  tcattcgcc  2520
cacgtcaat  gaagcagtg  agaggcgag  tgccccctg  gctcgtgca  cagatggag  2580
gccggcgcg  cagcatgct  gagacagcc  agcactgtt  cacatcagc  gcccgctgc  2640
agggtgatg  tgacgagga  gagtggctc  tccactaca  gctgggcaa  gtggctgag  2700
agcagcagc  gccacccac  gtttacttg  tgcactaca  gcaggctgg  cactacctg  2760
acgaggagg  tgcccgcta  cccaagaag  tccactacc  caacccacc  gagctggcc  2820
tggaggccc  ggaggtgta  tttcggctc  atgcttcca  cctgaagct  ctggggaag  2880
ccgattctg  ggttggtgc  gaggtcctg  tcaacttta  gaaggaggc  gcagaagga  2940
cctttgcca  gggcgagga  aagaacaca  ccaaagctt  agaaaagga  aaggcctgc  3000
tggtggacg  ggactccca  tcttcagct  ggacactgc  gggccccgg  gcctccctc  3060
cctcctcct  tggcccagg  ctgacatcc  caccttaca  agccactcc  attgaccac  3120
attacgtca  atgtaaaaa  ccccaccag  aggcaacgc  ggacgaccg  agccaggac  3180
gcacagccg  agcactctc  gactctagc  caacgcagg  cttctttaa  gagcccacc  3240
gcttactgg  aggctccag  aaatcctac  cagagaaga  gctgcccat  ctcagttcc  3300
aagcaggag  gacgggtaa  gatcttcag  gggccacag  agaaagagg  aaaaacgag  3360
agtcattgg  gagtacaga  ggcttccgg  ctgcagagc  aggtgtcca  aagcctgct  3420
cagaaaccc  agcctctgc  tgcatccct  gcaagccct  agcatccac  cccaccctg  3480
gggatggga  gaagagagg  gacctccca  gggagccag  ggccttccc  caggggctg  3540
cggctggtg  tgaggagca  cggcagttt  tcacagagc  gtgcatcgc  tccttccgc  3600
tgtgcctga  ccgcttccc  cagcactat  agagtctct  ccgtctggc  ttcctctac  3660
cctacagca  gacccaccg  aacctccag  gggcccgcg  cgtgttgct  ggcagcagt  3720
tcccgtggc  acaactgca  cacatgccg  cacaggggc  cttctgcga  aggaacaag  3780
ccaatttct  caacggcat  tggcggatc  ccgtggacg  gattgaccg  ccgggcagc  3840
ttgcctggc  catgaaccg  tccatcgtg  tgctgctca  ggtgctggc  cagctgcgg  3900
accacagca  cctgctgaa  gtgtcctcc  tgcttcagc  gaccccaga  cagggcaag  3960
agtatctgc  agatgctga  cgccaggtc  tggcgcagc  ggccttcat  ctcactgtg  4020
aggtgctcg  agacacgct  agcgagctc  cagaggggt  agaacgccc  gggcccaag  4080
tctgtggcc  ccccggagc  aggatgacc  ccgatgtct  acacaaggc  agtcctgag  4140
atggccagg  gggcctccc  cagccgaag  agccccctc  ggctgatgg  tcagggcca  4200
ggcccgagc  aggaggcaa  gtgggcctc  tcaaccacc  gcctgtggc  atggatgca  4260
gagacagtg  agaccaaag  ggggagcgg  aggataaag  gagcccacg  gcagggccc  4320
ctgagccca  ggacacgag  gaggccact  tttgccact  agacttgga  cggacacca  4380
ccctgctgc  aggtcgccc  gcaagggac  ggggccccg  gagccggcc  actgagctg  4440
ccctggagg  gctgagcat  agtgcccgg  agcagccca  cccgctcac  ccagcccag  4500
cagcccccg  ccccgcccc  gccaccacc  cagggacca  ggcaggggg  cacccggag  4560
agccgctct  ccggctcag  cgcaagagg  agctcctgg  ggacacaga  tcaggcaag  4620
cacttctgt  ggatgccta  cgtgtgtgg  agcagggcc  gaagggtgt  gcctatgac  4680
tgggccgtg  ggagaggat  atgtcggag  cctacatgc  catcaagca  gtggatgag  4740
aggctgcgc  ggagcaggc  gtgaagttc  gccaggtcc  tcttggggc  gccgcccag  4800
gacaggcct  gggggacac  cccaccact  caaagcacc  caaagacag  cgagagaac  4860
tctttcctg  gacagtggt  cccacagcc  ctgaccctg  gccagctga  tctgtccag  4920
ggcccagtg  tgctcacac  aagcctcgc  ctgcactag  tgccgccac  actattatc  4980
cctgccctc  gtcagcatc  gcttccacc  tggaccagt  caaggaccc  gggcctccc  5040
ggccacaca  gcctgaagc  acccccagc  tggcctctc  gggcccaga  ggagaagag  5100
tggcgagag  ggcagaggg  accagcttc  cgcctcagg  gccacggca  agtccgcag  5160
tgaagatgg  ccccacaag  tccccggca  agccacact  ctggccggc  gaggctgcc  5220
tgggcacag  cgctgagcc  acctgcagc  aggagggga  actgaggcc  gagccgaga  5280
gggatgggg  ggctcagga  gctgcgagt  agactcagc  cctgagctc  cccccaaca  5340
ctgccagct  caaggcccc  agcagtggg  gtgcccagc  accagaggg  cacccaggc  5400
agcctgagc  cagccgggc  aagtcccgc  ccctgccca  catgccaaa  ctggtcatc  5460
cctccgccg  caccaagtt  ccccctgag  tcaccgtca  gccacccac  ccaaccctg  5520
tctccccca  aggcagcat  tcggaggag  ccaagcaga  gctgaagtc  gccatcctt  5580
ctgcccagt  tgctgccaa  gtgaggaag  agagcctat  ccagccagc  ctggaggtc  5640
tggagacat  cagccagga  tcctcgctg  agagcgaga  agacgagga  gacgactac  5700
tggacattt  aggggccac  gcagcccca  cgccacgcc  caggggacc  gccaggcct  5760
gaatgcccc  tgggcagga  cctgggcag  accagaggc  cacatggat  ccactcccc  5820
cacagcccc  aggcctgcc  agcccacct  ctcatggca  cctccctgt  cccaggtca  5880
gctgtccac  ccacatggg  gcccagagg  ggaggggcc  gccttagcc  tgtgaaggt  5940
gattggtcg  catctgcac  ccaggcggc  tccttttct  tgaagtgtt  actttgtaa  6000
tctgcccac  cccagctgg  catatccac  cctcgacgc  gggatgagc  ggctctgcc  6060
gtgtcacag  ggaggggtc  tttagggcc  ggctcaccc  tcacccttt  tttggttgc  6120
tttctaata  agatggaac  gtt  6143



<210> 931
<211> 2220
<212> PRT
<213> Homo sapiens
<308> Q9Y6J0
<400> 931

Met Ile Arg Ile Ala Ala Leu Asn Ala Ser Ser Thr Ile Glu Asp Asp 
  1               5                  10                  15
His Glu Gly Ser Phe Lys Ser His Lys Thr Gln Thr Lys Glu Ala Gln 
             20                  25                  30
Glu Ala Glu Ala Phe Ala Leu Tyr His Lys Ala Leu Asp Leu Gln Lys 
         35                  40                  45
His Asp Arg Phe Glu Glu Ser Ala Lys Ala Tyr His Glu Leu Leu Glu 
     50                  55                  60
Ala Ser Leu Leu Arg Glu Ala Val Ser Ser Gly Asp Glu Lys Glu Gly 
 65                  70                  75                  80
Leu Lys His Pro Gly Leu Ile Leu Lys Tyr Ser Thr Tyr Lys Asn Leu 
                 85                  90                  95
Ala Gln Leu Ala Ala Gln Arg Glu Asp Leu Glu Thr Ala Met Glu Phe 
             100                105                110
Tyr Leu Glu Ala Val Met Leu Asp Ser Thr Asp Val Asn Leu Trp Tyr 
         115                120                125
Lys Ile Gly His Val Ala Leu Arg Leu Ile Arg Ile Pro Leu Ala Arg 
     130                135                140
His Ala Phe Glu Glu Gly Leu Arg Cys Asn Pro Asp His Trp Pro Cys 
 145                150                155                160
Leu Asp Asn Leu Ile Thr Val Leu Tyr Thr Leu Ser Asp Tyr Thr Thr 
                 165                170                175
Cys Leu Tyr Phe Ile Cys Lys Ala Leu Glu Lys Asp Cys Arg Tyr Ser 
             180                185                190
Lys Gly Leu Val Leu Lys Glu Lys Ile Phe Glu Glu Gln Pro Cys Leu 
         195                200                205
Arg Lys Asp Ser Leu Arg Met Phe Leu Lys Cys Asp Met Ser Ile His 
     210                215                220
Asp Val Ser Val Ser Ala Ala Glu Thr Gln Ala Ile Val Asp Glu Ala 
 225                230                235                240
Leu Gly Leu Arg Lys Lys Arg Gln Ala Leu Ile Val Arg Glu Lys Glu 
                 245                250                255
Pro Asp Leu Lys Leu Val Gln Pro Ile Pro Phe Phe Thr Trp Lys Cys 
             260                265                270
Leu Gly Glu Ser Leu Leu Ala Met Tyr Asn His Leu Thr Thr Cys Glu 
         275                280                285
Pro Pro Arg Pro Ser Leu Gly Lys Arg Ile Asp Leu Ser Asp Tyr Gln 
     290                295                300
Asp Pro Ser Gln Pro Leu Glu Ser Ser Met Val Val Thr Pro Val Asn 
 305                310                315                320
Val Ile Gln Pro Ser Thr Val Ser Thr Asn Pro Ala Val Ala Val Ala 
                 325                330                335
Glu Pro Val Val Ser Tyr Thr Ser Val Ala Thr Thr Ser Phe Pro Leu 
             340                345                350
His Ser Pro Gly Leu Leu Glu Thr Gly Ala Pro Val Gly Asp Ile Ser 
         355                360                365
Gly Gly Asp Lys Ser Lys Lys Gly Val Lys Arg Lys Lys Ile Ser Glu 
     370                375                380
Glu Ser Gly Glu Thr Ala Lys Arg Arg Ser Ala Arg Val Arg Asn Thr 
 385                390                395                400
Lys Cys Lys Lys Glu Glu Lys Val Asp Phe Gln Glu Leu Leu Met Lys 
                 405                410                415
Phe Leu Pro Ser Arg Leu Arg Lys Leu Asp Pro Glu Glu Glu Asp Asp 
             420                425                430
Ser Phe Asn Asn Tyr Glu Val Gln Ser Glu Ala Lys Leu Glu Ser Phe 
         435                440                445
Pro Ser Ile Gly Pro Gln Arg Leu Ser Phe Asp Ser Ala Thr Phe Met 
     450                455                460
Glu Ser Glu Lys Gln Asp Val His Glu Phe Leu Leu Glu Asn Leu Thr 
 465                470                475                480
Asn Gly Gly Ile Leu Glu Leu Met Met Arg Tyr Leu Lys Ala Met Gly 
                 485                490                495
His Lys Phe Leu Val Arg Trp Pro Pro Gly Leu Ala Glu Val Val Leu 
             500                505                510
Ser Val Tyr His Ser Trp Arg Arg His Ser Thr Ser Leu Pro Asn Pro 
         515                520                525
Leu Leu Arg Asp Cys Ser Asn Lys His Ile Lys Asp Met Met Leu Met 
     530                535                540
Ser Leu Ser Cys Met Glu Leu Gln Leu Asp Gln Trp Leu Leu Thr Lys 
 545                550                555                560
Gly Arg Ser Ser Ala Val Ser Pro Arg Asn Cys Pro Ala Gly Met Val 
                 565                570                575
Asn Gly Arg Phe Gly Pro Asp Phe Pro Gly Thr His Cys Leu Gly Asp 
             580                585                590
Leu Leu Gln Leu Ser Phe Ala Ser Ser Gln Arg Asp Leu Phe Glu Asp 
         595                600                605
Gly Trp Leu Glu Phe Val Val Arg Val Tyr Trp Leu Lys Ala Arg Phe 
     610                615                620
Leu Ala Leu Gln Gly Asp Met Glu Gln Ala Leu Glu Asn Tyr Asp Ile 
 625                630                635                640
Cys Thr Glu Met Leu Gln Ser Ser Thr Ala Ile Gln Val Glu Ala Gly 
                 645                650                655
Ala Glu Arg Arg Asp Ile Val Ile Arg Leu Pro Asn Leu His Asn Asp 
             660                665                670
Ser Val Val Ser Leu Glu Glu Ile Asp Lys Asn Leu Lys Ser Leu Glu 
         675                680                685
Arg Cys Gln Ser Leu Glu Glu Ile Gln Arg Leu Tyr Glu Ala Gly Asp 
     690                695                700
Tyr Lys Ala Val Val His Leu Leu Arg Pro Thr Leu Cys Thr Ser Gly 
 705                710                715                720
Phe Asp Arg Ala Lys His Leu Glu Phe Met Thr Ser Ile Pro Glu Arg 
                 725                730                735
Pro Ala Gln Leu Leu Leu Leu Gln Asp Ser Leu Leu Arg Leu Lys Asp 
             740                745                750
Tyr Arg Gln Cys Phe Glu Cys Ser Asp Val Ala Leu Asn Glu Ala Val 
         755                760                765
Gln Gln Met Val Asn Ser Gly Glu Ala Ala Ala Lys Glu Glu Trp Val 
     770                775                780
Ala Thr Val Thr Gln Leu Leu Met Gly Ile Glu Gln Ala Leu Ser Ala 
 785                790                795                800
Asp Ser Ser Gly Ser Ile Leu Lys Val Ser Ser Ser Thr Thr Gly Leu 
                 805                810                815
Val Arg Leu Thr Asn Asn Leu Ile Gln Val Ile Asp Cys Ser Met Ala 
             820                825                830
Val Gln Glu Glu Ala Lys Glu Pro His Val Ser Ser Val Leu Pro Trp 
         835                840                845
Ile Ile Leu His Arg Ile Ile Trp Gln Glu Glu Asp Thr Phe His Ser 
     850                855                860
Leu Cys His Gln Gln Gln Leu Gln Asn Pro Ala Glu Glu Gly Met Ser 
 865                870                875                880
Glu Thr Pro Met Leu Pro Ser Ser Leu Met Leu Leu Asn Thr Ala His 
                 885                890                895
Glu Tyr Leu Gly Arg Arg Ser Trp Cys Cys Asn Ser Asp Gly Ala Leu 
             900                905                910
Leu Arg Phe Tyr Val Arg Val Leu Gln Lys Glu Leu Ala Ala Ser Thr 
         915                920                925
Ser Glu Asp Thr His Pro Tyr Lys Glu Glu Leu Glu Thr Ala Leu Glu 
     930                935                940
Gln Cys Phe Tyr Cys Leu Tyr Ser Phe Pro Ser Lys Lys Ser Lys Ala 
 945                950                955                960
Arg Tyr Leu Glu Glu His Ser Ala Gln Gln Val Asp Leu Ile Trp Glu 
                 965                970                975
Asp Ala Leu Phe Met Phe Glu Tyr Phe Lys Pro Lys Thr Leu Pro Glu 
             980                985                990
Phe Asp Ser Tyr Lys Thr Ser Thr Val Ser Ala Asp Leu Ala Asn Leu 
         995                1000                1005
Leu Lys Arg Ile Ala Thr Ile Val Pro Arg Thr Glu Arg Pro Ala Leu 
     1010                1015                1020
Ser Leu Asp Lys Val Ser Ala Tyr Ile Glu Gly Thr Ser Thr Glu Val 
 1025                1030                1035                1040
Pro Cys Leu Pro Glu Gly Ala Asp Pro Ser Pro Pro Val Val Asn Glu 
                 1045                1050                1055
Leu Tyr Tyr Leu Leu Ala Asp Tyr His Phe Lys Asn Lys Glu Gln Ser 
             1060                1065                1070
Lys Ala Ile Lys Phe Tyr Met His Asp Ile Cys Ile Cys Pro Asn Arg 
         1075                1080                1085
Phe Asp Ser Trp Ala Gly Met Ala Leu Ala Arg Ala Ser Arg Ile Gln 
     1090                1095                1100
Asp Lys Leu Asn Ser Asn Glu Leu Lys Ser Asp Gly Pro Ile Trp Lys 
 1105                1110                1115                1120
His Ala Thr Pro Val Leu Asn Cys Phe Arg Arg Ala Leu Glu Ile Asp 
                 1125                1130                1135
Ser Ser Asn Leu Ser Leu Trp Ile Glu Tyr Gly Thr Met Ser Tyr Ala 
             1140                1145                1150
Leu His Ser Phe Ala Ser Arg Gln Leu Lys Gln Trp Arg Gly Glu Leu 
         1155                1160                1165
Pro Pro Glu Leu Val Gln Gln Met Glu Gly Arg Arg Asp Ser Met Leu 
     1170                1175                1180
Glu Thr Ala Lys His Cys Phe Thr Ser Ala Ala Arg Cys Glu Gly Asp 
 1185                1190                1195                1200
Gly Asp Glu Glu Glu Trp Leu Ile His Tyr Met Leu Gly Lys Val Ala 
                 1205                1210                1215
Glu Lys Gln Gln Gln Pro Pro Thr Val Tyr Leu Leu His Tyr Arg Gln 
             1220                1225                1230
Ala Gly His Tyr Leu His Glu Glu Ala Ala Arg Tyr Pro Lys Lys Ile 
         1235                1240                1245
His Tyr His Asn Pro Pro Glu Leu Ala Met Glu Ala Leu Glu Val Tyr 
     1250                1255                1260
Phe Arg Leu His Ala Ser Ile Leu Lys Leu Leu Gly Lys Pro Asp Ser 
 1265                1270                1275                1280
Gly Val Gly Ala Glu Val Leu Val Asn Phe Met Lys Glu Ala Ala Glu 
                 1285                1290                1295
Gly Pro Phe Ala Arg Gly Glu Glu Lys Asn Thr Pro Lys Ala Ser Glu 
             1300                1305                1310
Lys Glu Lys Ala Cys Leu Val Asp Glu Asp Ser His Ser Ser Ala Gly 
         1315                1320                1325
Thr Leu Pro Gly Pro Gly Ala Ser Leu Pro Ser Ser Ser Gly Pro Gly 
     1330                1335                1340
Leu Thr Ser Pro Pro Tyr Thr Ala Thr Pro Ile Asp His Asp Tyr Val 
 1345                1350                1355                1360
Lys Cys Lys Lys Pro His Gln Gln Ala Thr Pro Asp Asp Arg Ser Gln 
                 1365                1370                1375
Asp Ser Thr Ala Val Ala Leu Ser Asp Ser Ser Ser Thr Gln Asp Phe 
             1380                1385                1390
Phe Asn Glu Pro Thr Ser Leu Leu Glu Gly Ser Arg Lys Ser Tyr Thr 
         1395                1400                1405
Glu Lys Arg Leu Pro Ile Leu Ser Ser Gln Ala Gly Ala Thr Gly Lys 
     1410                1415                1420
Asp Leu Gln Gly Ala Thr Glu Glu Arg Gly Lys Asn Glu Glu Ser Leu 
 1425                1430                1435                1440
Glu Ser Thr Glu Gly Phe Arg Ala Ala Glu Gln Gly Val Gln Lys Pro 
                 1445                1450                1455
Ala Ala Glu Thr Pro Ala Ser Ala Cys Ile Pro Gly Lys Pro Ser Ala 
             1460                1465                1470
Ser Thr Pro Thr Leu Trp Asp Gly Lys Lys Arg Gly Asp Leu Pro Gly 
         1475                1480                1485
Glu Pro Val Ala Phe Pro Gln Gly Leu Pro Ala Gly Ala Glu Glu Gln 
     1490                1495                1500
Arg Gln Phe Leu Thr Glu Gln Cys Ile Ala Ser Phe Arg Leu Cys Leu 
 1505                1510                1515                1520
Ser Arg Phe Pro Gln His Tyr Lys Ser Leu Tyr Arg Leu Ala Phe Leu 
                 1525                1530                1535
Tyr Thr Tyr Ser Lys Thr His Arg Asn Leu Gln Trp Ala Arg Asp Val 
             1540                1545                1550
Leu Leu Gly Ser Ser Ile Pro Trp Gln Gln Leu Gln His Met Pro Ala 
         1555                1560                1565
Gln Gly Leu Phe Cys Glu Arg Asn Lys Thr Asn Phe Phe Asn Gly Ile 
     1570                1575                1580
Trp Arg Ile Pro Val Asp Glu Ile Asp Arg Pro Gly Ser Phe Ala Trp 
 1585                1590                1595                1600
His Met Asn Arg Ser Ile Val Leu Leu Leu Lys Val Leu Ala Gln Leu 
                 1605                1610                1615
Arg Asp His Ser Thr Leu Leu Lys Val Ser Ser Met Leu Gln Arg Thr 
             1620                1625                1630
Pro Asp Gln Gly Lys Lys Tyr Leu Arg Asp Ala Asp Arg Gln Val Leu 
         1635                1640                1645
Ala Gln Arg Ala Phe Ile Leu Thr Val Lys Val Leu Glu Asp Thr Leu 
     1650                1655                1660
Ser Glu Leu Ala Glu Gly Ser Glu Arg Pro Gly Pro Lys Val Cys Gly 
 1665                1670                1675                1680
Leu Pro Gly Ala Arg Met Thr Thr Asp Val Ser His Lys Ala Ser Pro 
                 1685                1690                1695
Glu Asp Gly Gln Glu Gly Leu Pro Gln Pro Lys Lys Pro Pro Leu Ala 
             1700                1705                1710
Asp Gly Ser Gly Pro Gly Pro Glu Pro Gly Gly Lys Val Gly Leu Leu 
         1715                1720                1725
Asn His Arg Pro Val Ala Met Asp Ala Gly Asp Ser Ala Asp Gln Ser 
     1730                1735                1740
Gly Glu Arg Lys Asp Lys Glu Ser Pro Arg Ala Gly Pro Thr Glu Pro 
 1745                1750                1755                1760
Met Asp Thr Ser Glu Ala Thr Val Cys His Ser Asp Leu Glu Arg Thr 
                 1765                1770                1775
Pro Pro Leu Leu Pro Gly Arg Pro Ala Arg Asp Arg Gly Pro Glu Ser 
             1780                1785                1790
Arg Pro Thr Glu Leu Ser Leu Glu Glu Leu Ser Ile Ser Ala Arg Gln 
         1795                1800                1805
Gln Pro Thr Pro Leu Thr Pro Ala Gln Pro Ala Pro Ala Pro Ala Pro 
     1810                1815                1820
Ala Thr Thr Thr Gly Thr Arg Ala Gly Gly His Pro Glu Glu Pro Leu 
 1825                1830                1835                1840
Ser Arg Leu Ser Arg Lys Arg Lys Leu Leu Glu Asp Thr Glu Ser Gly 
                 1845                1850                1855
Lys Thr Leu Leu Leu Asp Ala Tyr Arg Val Trp Gln Gln Gly Gln Lys 
             1860                1865                1870
Gly Val Ala Tyr Asp Leu Gly Arg Val Glu Arg Ile Met Ser Glu Thr 
         1875                1880                1885
Tyr Met Leu Ile Lys Gln Val Asp Glu Glu Ala Ala Leu Glu Gln Ala 
     1890                1895                1900
Val Lys Phe Cys Gln Val His Leu Gly Ala Ala Ala Gln Arg Gln Ala 
 1905                1910                1915                1920
Ser Gly Asp Thr Pro Thr Thr Pro Lys His Pro Lys Asp Ser Arg Glu 
                 1925                1930                1935
Asn Phe Phe Pro Val Thr Val Val Pro Thr Ala Pro Asp Pro Val Pro 
             1940                1945                1950
Ala Asp Ser Val Gln Arg Pro Ser Asp Ala His Thr Lys Pro Arg Pro 
         1955                1960                1965
Ala Leu Ala Ala Ala Thr Thr Ile Ile Thr Cys Pro Pro Ser Ala Ser 
     1970                1975                1980
Ala Ser Thr Leu Asp Gln Ser Lys Asp Pro Gly Pro Pro Arg Pro His 
 1985                1990                1995                2000
Arg Pro Glu Ala Thr Pro Ser Met Ala Ser Leu Gly Pro Glu Gly Glu 
                 2005                2010                2015
Glu Leu Ala Arg Val Ala Glu Gly Thr Ser Phe Pro Pro Gln Glu Pro 
             2020                2025                2030
Arg His Ser Pro Gln Val Lys Met Ala Pro Thr Ser Ser Pro Ala Glu 
         2035                2040                2045
Pro His Cys Trp Pro Ala Glu Ala Ala Leu Gly Thr Gly Ala Glu Pro 
     2050                2055                2060
Thr Cys Ser Gln Glu Gly Lys Leu Arg Pro Glu Pro Arg Arg Asp Gly 
 2065                2070                2075                2080
Glu Ala Gln Glu Ala Ala Ser Glu Thr Gln Pro Leu Ser Ser Pro Pro 
                 2085                2090                2095
Thr Ala Ala Ser Ser Lys Ala Pro Ser Ser Gly Ser Ala Gln Pro Pro 
             2100                2105                2110
Glu Gly His Pro Gly Lys Pro Glu Pro Ser Arg Ala Lys Ser Arg Pro 
         2115                2120                2125
Leu Pro Asn Met Pro Lys Leu Val Ile Pro Ser Ala Ala Thr Lys Phe 
     2130                2135                2140
Pro Pro Glu Ile Thr Val Thr Pro Pro Thr Pro Thr Leu Leu Ser Pro 
 2145                2150                2155                2160
Lys Gly Ser Ile Ser Glu Glu Thr Lys Gln Lys Leu Lys Ser Ala Ile 
                 2165                2170                2175
Leu Ser Ala Gln Ser Ala Ala Asn Val Arg Lys Glu Ser Leu Cys Gln 
             2180                2185                2190
Pro Ala Leu Glu Val Leu Glu Thr Ser Ser Gln Glu Ser Ser Leu Glu 
         2195                2200                2205
Ser Glu Thr Asp Glu Asp Asp Asp Tyr Met Asp Ile 
     2210                2215                2220



<210> 932
<211> 7272
<212> DNA
<213> Rattus norvegicus
<308> AF061947
<400> 932

ggccgcctc  gaggtccgt  cagggctcc  gtgagcgcg  ggaggtggg  acacgcgac  60
cccgctctc  attacgggc  cggtgggcc  aagcctggc  cgagacccg  aggcgctga  120
aaggacctt  tggccacgc  tgctcctcc  cgcgccccg  cgctgcgcc  ggaggcgcc  180
agggtgggt  actgggacc  cagctcgaa  ccatccctt  ctgtgcgtc  tttcattca  240
cttcacagc  gcccagaga  ggactgtca  ctggcacat  ccccaccag  gatgggaag  300
gatcctcca  ggtggcgct  aatctctga  tatgattcg  attgcagcc  taaatgcca  360
ctccacaat  gaagatgac  atgaaggaa  ctttaaaag  cacaaaatc  agacaaagg  420
ggctcagga  gcagaagcc  ttgccctat  ccacaaggc  ctggatctg  agaaacatg  480
caggtttga  gagtctgcc  aggcctacc  tgaactcct  gaggctcgc  tgctgcgag  540
ggcagtttc  tccggagat  agaaggaag  gctgaagca  cctggactg  tactgaaat  600
ttctacgta  aagaacctg  cccagctgg  agcccagcg  gaggacctg  agacagcca  660
ggagtttta  ttggaggcc  tgatgctgg  ttccacaga  gtcaacctt  ggtacaaga  720
tggacatgt  gccctgagg  tcatccggc  tcccctggc  cgccatgct  ttgaggaag  780
gctccggtg  aatcctgac  actggccct  cttggacaa  ctcatcact  ttttgtaca  840
cctcagcga  tacacaaca  gtctttact  catctgcaa  gcactggag  aagactgcc  900
ctacagcaa  ggcctggtt  tcaaggaga  gatttttga  gagcaacct  gtctccgaa  960
ggactcact  cgaatgttc  tcaaatgtg  catgtcagt  cacgaggtg  cagtgaatg  1020
agcagagac  caggccatt  tagacgagg  tctggggct  cggaagaag  ggcaggcgt  1080
gatcgtgcg  gaaaaggag  cagacctga  actagtgca  cccatccct  tcttcacgt  1140
gaagtgcct  ggagagagc  tgcttgcca  gtacaatca  ctcaccacg  gtgagcctc  1200
caggcccag  ctgggcaag  ggattgacc  gtctgacta  caggatccc  gccagctgc  1260
tgccccctc  atcgtggtt  ctcctgtca  tgtggtcca  ccaagtcct  tttgcacca  1320
tccaactgt  gctgtggcc  agcctgtgc  ctcctacac  tctgtgacc  caaccagct  1380
cccactgca  agtcctggc  tgctggaca  gggcactcc  atgggtgat  tttccggag  1440
agataaatc  aaaaaaggg  tgaagcgta  gaagacttt  gaggaaagt  gggagacag  1500
aaagcggag  tctgcccgt  tccgcaaca  caagtgcaa  aaagaagag  aggtggatt  1560
ccaggggct  ctggtaaag  tcctgccgt  caggttaag  aaactggac  ctgaggagg  1620
agatgatcc  tttaacaac  atgaagttc  gtcagaagc  aaactggag  gcttctcga  1680
cgtgggacc  catcgactg  ccttcgatt  agccacatt  atggaatct  agaagcagg  1740
tgtgcatgc  ttcctgatg  agaacctga  caatggggg  gtcctggag  tcatgatgc  1800
ctacctgaa  agcatgggc  acaagttcc  gctgaagtg  cccccaggc  tggcggagg  1860
cgtacttag  gtctaccac  gctggagga  gcacagtac  agcctgccc  acccattgc  1920
gagggactg  agcaacaag  acatcaagg  catgatgct  atgtctctt  cctgcatgg  1980
gctccaact  gaccagtgg  ttctgacca  aggcagaag  tccacggtg  ctccccgga  2040
ctgccctgc  ggtgtggtg  caggcaggt  tgggccaga  ttcccagga  cccactgcc  2100
gggtgacct  ctgcagctg  catttgcgt  atctcagcg  gatctgttt  aggacggct  2160
gctggagtt  gtggtccgt  tttactggc  gaaggcacg  ttcttggca  tacagggcg  2220
tatggagca  gctttggag  actatgata  ctgcacaga  atactccag  gctccacgg  2280
tctccaagc  caggcaggg  ctgagcaaa  ggacattgt  atccggctg  ccaacctgc  2340
caatgactc  attgtttct  tggaggaaa  tgataagaa  ctgaagtct  tggaaaggt  2400
ccagtccct  gaggagatt  agcggctgt  tgaggcggg  gactacaag  ccgtggtgc  2460
gctgctccg  cccactctg  gcaccagtg  ctttgaccg  gccaaacac  tggagttta  2520
gacttccat  cccgagagg  cggcccagc  gcttctgct  caggactct  tgctccggc  2580
ggaggagca  aggcagtgc  ttgaatgct  tgacgtggc  ctcaatgaa  ctgtccagc  2640
gatgctgaa  tcgagtgac  ctgcggcca  ggaggagtg  gcggccaca  tgacgcagc  2700
gctgctagg  atggagcag  cactgtcat  agacagcag  ggcagcatc  tgaaggagt  2760
ctcctctcc  acgggcctt  tccggctca  caacaacct  attcaggtc  tcgactgca  2820
catggctgt  caggaggag  ccaaggagc  ctatgtctc  tccgtgctg  cctggatca  2880
cctccacag  atcatctgg  aggaggaag  cactttccg  tctctgtgc  accagcagc  2940
gctccagaa  ccaacggaa  aagggatct  ggagatgcc  atgctccca  cttccctca  3000
gctgctcaa  acagcacat  agtacctgg  caggaggtc  tggtgctgc  attcagatg  3060
agcgctgct  cgattctat  tgcacgttc  ccaaaagga  cttgctgcg  ctgcctctg  3120
ggacactca  ccctacaag  aggagctgg  gaccgcctt  gagcagtgt  tctactgcc  3180
ctacagctt  cccagcaag  agagcaagg  caggtacct  gaggagcac  cagcccagc  3240
ggtggacct  acctgggag  acgccctgt  catgtttga  tacttcaag  ccaagaccc  3300
ccctgagtt  gacagctac  agaccagca  cgtctctgc  gacttggca  acctgttga  3360
aagaatcgc  accattgtg  cgcgcacag  gaagcccgc  ctgagcatg  acaaagtct  3420
tgcctacat  gagggaacc  cagcggagg  gccctgcct  cctgacggg  cagaccccg  3480
ccctccagt  ctgaatgag  tctactacc  cctggctga  tatcacttc  aaaacaaag  3540
gcagtccaa  gccatcaag  tctacatgc  tgacatttg  atctgccct  acaggtttg  3600
ttcctgggc  ggcatggct  tggcccggg  cagccgaat  caggacaag  tgaactcaa  3660
tgagctgaa  agtgatgga  ccatctgga  acatgccac  cctgttctg  actgcttcc  3720
gagggccct  gagattgac  gctctaact  gtccttgtg  attgagtat  gcaccatgt  3780
ctatgcctt  cactcattc  cgtcccgtc  gctgaagca  tggcgagcc  agctgcctc  3840
tgaggttgt  cagcagatg  aggatcggc  agacagcat  ctggagaca  ccaggcact  3900
tttcacgtc  gcagcccac  gcgagggtg  tggcgatga  gaggagtgg  tcattcact  3960
catgctggg  aaagtggca  agaagcagc  gcagccgcc  accgtgtac  tgctgcact  4020
ccgtcaggc  ggccactac  tacacgagg  ggccgcccg  taccctaag  agattcact  4080
ccacaaccc  cccgagctg  ccatggaag  cctggaggt  tacttccgg  tccatgcgt  4140
catcctgaa  ctcctgggc  aacctgact  tggggttag  gcagaggtc  tggtcagct  4200
tatgaagga  gcagcagaa  gaccttttg  caggggcga  gagaagaat  cacctaaag  4260
ttcagaaaa  gagaaggcc  gcctggtgg  tgaggactc  cactcttca  ctgggacac  4320
gccgggccc  ggagcctcc  ttccctcct  ctctggccc  ggtctgaca  ccccacctt  4380
cacagccac  ccgattgac  acgattacg  caaatgtaa  aaaccccgt  agcaggcga  4440
gccggacga  cgaagccag  acagcacag  tgtggcact  tcagactcc  gctcaacac  4500
ggacttctt  aatgagccc  caagtttgc  ggacggttc  cgaaagctc  ttccagaga  4560
gaggatctc  gggctcagt  ctcaagcag  accaagtgg  aaagacctt  cagggccca  4620
agaggaaag  ggaaaaacg  aggagtctt  ggagagcac  gaggccttc  gggttgtag  4680
accaagcgt  cagaagcct  tggcagatt  ctcggcctc  gcttacatc  ccagcaagc  4740
cgcagtgtc  acgccccct  cgtgggatg  gaagaagag  agtgacccc  taggggagc  4800
agtggcttt  cctcagggg  tgccagcag  tgctgagga  cagcgccag  tcctcacag  4860
gcagtgcat  gcctccttc  gcctgtgct  gagtcgctt  ccacagcac  acaagagtc  4920
ctaccggct  gcctttctc  acacctaca  caagactca  cggaacctc  agtgggccc  4980
tgatgtgtt  ctaggcagc  gtatcccat  gcaacaact  cagcacatg  cggcacagg  5040
gctcttctg  gagaggaac  agaccaatt  cttcaacgg  atctggcgg  tccccgtgg  5100
tgagattga  cggcccggc  gcttcgcct  gcacatgaa  cgctccatc  tgctgctac  5160
caaggttct  gcccagctc  gggaccaca  caccctgtt  aaggtgtcc  ccatgctgc  5220
gcggacacc  gaccagggc  agaaatatc  gcgagatgc  gaccgccag  tgctggcac  5280
gcgcgcctt  atcctcact  tgaaggtgc  ggaggacac  ctgagtgag  ttgcagagg  5340
gttagagca  ccaggatcc  aggcctgtg  cctctctgg  gccaggatg  ccaccgatg  5400
ctcacacaa  gccagtccc  aggatggcc  ggaaagcct  ccacacccc  agaagctac  5460
tctagctga  ggctcagga  cagggcctg  gccaggggg  aaagtgggc  ctctccacc  5520
attgccagt  gccacagac  caagggaca  cacagagca  ggtggggag  cgaaagaca  5580
agagcgtcc  ccggtgggg  ccacagaac  catggacac  ggcgagact  ctgctcgcc  5640
cccagactt  gaaccgacg  cacgtctgt  gccaggccg  cccccaagg  accggggtc  5700
cgagagccg  tctgctgag  tttccctgg  ggagctgag  atcagcacc  ggcagcagc  5760
tgccccact  gtaccatcc  cagtaaccc  caccacagc  gctcccact  ccatggggg  5820
cagggcagc  gggcacccc  aggaggcac  gccaaggcc  aatcgaaag  ggaaactcc  5880
gcaggacac  gagtctggc  agacgctcc  tttggacgc  taccgtgtg  ggcagcagg  5940
ccagaaggc  atggcctat  acctgagcc  catcgagaa  atcatgtcg  agacttaca  6000
gctcatcaa  caggtggac  aggagactg  actggagca  gctgtgaag  tctgtcagg  6060
ccacctcgg  gctgctgcc  agagacagg  ctcaggaga  gcacccact  cccccaagc  6120
ccccaagga  agccgagag  atttcttcc  tgcaacagt  gccccctca  cacctgaca  6180
cacagcacc  gacgctctc  agcggccca  tgactccca  ctcaagcct  ggttggctg  6240
tgccatcac  tgccctccc  cagcatcag  ctctacccc  gaccctgga  ttccccagc  6300
acacaggcc  gaggctgtg  ccagcaggg  ccctctgag  cctgatgga  aagaggtgt  6360
aggagtgac  gagggtccc  gctttctat  ccaagaacc  cggcacagt  accagatga  6420
aatggctgc  actggtccc  tggccgagc  gcactgctg  ccagtggag  ctgcttgcc  6480
gacaggtgc  gagcccacc  tcagccaag  caccagcac  aaggtcccc  gcagtggaa  6540
tacccagac  cctgagagc  atcaaggca  aactgagtc  agcagagcc  agtcccgcc  6600
cctgcccaa  atgccaaag  tggtgatcc  ctcggccac  accaagttc  cccctgaga  6660
caccgtcac  ccacctacc  ccaccctgc  ctcccccaa  ggcagcatc  cagaggaga  6720
caagcagaa  ctgaagtct  ccatcctgt  tgcccaatc  gccgccaat  tgaggaagg  6780
gagcctgtg  cagccagcc  tggaggttc  ggagacatc  agccaggag  cctcattgg  6840
gagtgagac  gacgaggac  atgacttta  ggacgtatg  cgggttcac  cagaggcag  6900
gcctggggt  cctttggtc  agaccctgg  caaggccag  agcctattg  ggtatggtt  6960
cctgtggtc  cctaagcct  cccagcccc  tctttgcag  accctgccc  ggctcaggc  7020
gtccagagc  tgctggtcc  gaggacggt  cggcctgtc  taggcacat  cactgctgc  7080
gtctgcaca  ccgggatgc  gccgccgcc  ccgcttctt  ttttaatga  atactgact  7140
tctctacaa  cccgtgtgt  ctgaccagg  ccacagtcc  gtgccgagg  gacatcagg  7200
gcctagctc  ccccacacc  tttttygtc  ttgttgctt  tttttctaa  aaagatgga  7260
aatggtaaa  aa  7272



<210> 933
<211> 2182
<212> PRT
<213> Rattus norvegicus
<308> O88480
<400> 933

Met Ile Arg Ile Ala Ala Leu Asn Ala Ser Ser Thr Ile Glu Asp Asp 
  1               5                  10                  15
His Glu Gly Ser Phe Lys Ser His Lys Ile Gln Thr Lys Glu Ala Gln 
             20                  25                  30
Glu Ala Glu Ala Phe Ala Leu Tyr His Lys Ala Leu Asp Leu Gln Lys 
         35                  40                  45
His Asp Arg Phe Glu Glu Ser Ala Lys Ala Tyr His Glu Leu Leu Glu 
     50                  55                  60
Ala Arg Leu Leu Arg Glu Ala Val Ser Ser Gly Asp Glu Lys Glu Gly 
 65                  70                  75                  80
Leu Lys His Pro Gly Leu Ile Leu Lys Tyr Ser Thr Tyr Lys Asn Leu 
                 85                  90                  95
Ala Gln Leu Ala Ala Gln Arg Glu Asp Leu Glu Thr Ala Met Glu Phe 
             100                105                110
Tyr Leu Glu Ala Val Met Leu Asp Ser Thr Asp Val Asn Leu Trp Tyr 
         115                120                125
Lys Ile Gly His Val Ala Leu Arg Leu Ile Arg Leu Pro Leu Ala Arg 
     130                135                140
His Ala Phe Glu Glu Gly Leu Arg Cys Asn Pro Asp His Trp Pro Cys 
 145                150                155                160
Leu Asp Asn Leu Ile Thr Val Leu Tyr Thr Leu Ser Asp Tyr Thr Thr 
                 165                170                175
Cys Leu Tyr Phe Ile Cys Lys Ala Leu Glu Lys Asp Cys Arg Tyr Ser 
             180                185                190
Lys Gly Leu Val Leu Lys Glu Lys Ile Phe Glu Glu Gln Pro Cys Leu 
         195                200                205
Arg Lys Asp Ser Leu Arg Met Phe Leu Lys Cys Asp Met Ser Val His 
     210                215                220
Glu Val Ser Val Asn Ala Ala Glu Thr Gln Ala Ile Val Asp Glu Ala 
 225                230                235                240
Leu Gly Leu Arg Lys Lys Arg Gln Ala Leu Ile Val Arg Glu Lys Glu 
                 245                250                255
Pro Asp Leu Lys Leu Val Gln Pro Ile Pro Phe Phe Thr Trp Lys Cys 
             260                265                270
Leu Gly Glu Ser Leu Leu Ala Met Tyr Asn His Leu Thr Thr Cys Glu 
         275                280                285
Pro Pro Arg Pro Ser Leu Gly Lys Arg Ile Asp Leu Ser Asp Tyr Gln 
     290                295                300
Asp Pro Ser Gln Leu Leu Ala Pro Ser Ile Val Val Thr Pro Val Ser 
 305                310                315                320
Val Val Gln Pro Ser Pro Val Cys Thr Asn Pro Thr Val Ala Val Ala 
                 325                330                335
Glu Pro Val Leu Ser Tyr Thr Ser Val Thr Thr Thr Ser Phe Pro Leu 
             340                345                350
His Ser Pro Gly Leu Leu Asp Thr Gly Thr Pro Met Gly Asp Val Ser 
         355                360                365
Gly Gly Asp Lys Ser Lys Lys Gly Val Lys Arg Lys Lys Thr Leu Glu 
     370                375                380
Glu Ser Gly Glu Thr Ala Lys Arg Arg Ser Ala Arg Val Arg Asn Thr 
 385                390                395                400
Lys Cys Lys Lys Glu Glu Lys Val Asp Phe Gln Gly Leu Leu Val Lys 
                 405                410                415
Phe Leu Pro Ser Arg Leu Arg Lys Leu Asp Pro Glu Glu Glu Asp Asp 
             420                425                430
Pro Phe Asn Asn Tyr Glu Val Gln Ser Glu Ala Lys Leu Glu Ser Phe 
         435                440                445
Ser Asn Val Gly Pro His Arg Leu Ser Phe Asp Ser Ala Thr Phe Met 
     450                455                460
Glu Ser Glu Lys Gln Asp Val His Ala Phe Leu Met Glu Asn Leu Thr 
 465                470                475                480
Asn Gly Gly Val Leu Glu Leu Met Met Arg Tyr Leu Lys Ser Met Gly 
                 485                490                495
His Lys Phe Leu Leu Lys Trp Pro Pro Gly Leu Ala Glu Val Val Leu 
             500                505                510
Ser Val Tyr His Ser Trp Arg Arg His Ser Thr Ser Leu Pro Asn Pro 
         515                520                525
Leu Leu Arg Asp Cys Ser Asn Lys His Ile Lys Asp Met Met Leu Met 
     530                535                540
Ser Leu Ser Cys Met Glu Leu Gln Leu Asp Gln Trp Leu Leu Thr Lys 
 545                550                555                560
Gly Arg Ser Ser Thr Val Ser Pro Arg Asn Cys Pro Ala Gly Val Val 
                 565                570                575
Thr Gly Arg Phe Gly Pro Asp Phe Pro Gly Thr His Cys Leu Gly Asp 
             580                585                590
Leu Leu Gln Leu Ser Phe Ala Ser Ser Gln Arg Asp Leu Phe Glu Asp 
         595                600                605
Gly Trp Leu Glu Phe Val Val Arg Val Tyr Trp Leu Lys Ala Arg Phe 
     610                615                620
Leu Ala Leu Gln Gly Asp Met Glu Gln Ala Leu Glu Asn Tyr Asp Ile 
 625                630                635                640
Cys Thr Glu Ile Leu Gln Ser Ser Thr Ala Leu Gln Ala Gln Ala Gly 
                 645                650                655
Ala Glu Gln Arg Asp Ile Val Ile Arg Leu Pro Asn Leu His Asn Asp 
             660                665                670
Ser Ile Val Ser Leu Glu Glu Ile Asp Lys Asn Leu Lys Ser Leu Glu 
         675                680                685
Arg Cys Gln Ser Leu Glu Glu Ile Gln Arg Leu Phe Glu Ala Gly Asp 
     690                695                700
Tyr Lys Ala Val Val Gln Leu Leu Arg Pro Thr Leu Cys Thr Ser Gly 
 705                710                715                720
Phe Asp Arg Ala Lys His Leu Glu Phe Met Thr Ser Ile Pro Glu Arg 
                 725                730                735
Pro Ala Gln Leu Leu Leu Leu Gln Asp Ser Leu Leu Arg Leu Glu Glu 
             740                745                750
His Arg Gln Cys Phe Glu Cys Ser Asp Val Ala Leu Asn Glu Ala Val 
         755                760                765
Gln Gln Met Leu Asn Ser Ser Asp Ser Ala Ala Lys Glu Glu Trp Ala 
     770                775                780
Ala Thr Val Thr Gln Leu Leu Leu Gly Met Glu Gln Ala Leu Ser Ser 
 785                790                795                800
Asp Ser Arg Gly Ser Ile Leu Lys Glu Ser Ser Ser Pro Thr Gly Leu 
                 805                810                815
Val Arg Leu Thr Asn Asn Leu Ile Gln Val Ile Asp Cys Ser Met Ala 
             820                825                830
Val Gln Glu Glu Pro Lys Glu Pro Tyr Val Ser Ser Val Leu Pro Trp 
         835                840                845
Ile Ile Leu His Arg Ile Ile Trp Gln Glu Glu Asp Thr Phe Arg Ser 
     850                855                860
Leu Cys His Gln Gln Gln Leu Gln Asn Pro Thr Glu Glu Gly Ile Ser 
 865                870                875                880
Glu Met Pro Met Leu Pro Ser Ser Leu Met Leu Leu Asn Thr Ala His 
                 885                890                895
Glu Tyr Leu Gly Arg Arg Ser Trp Cys Cys Asn Ser Asp Gly Ala Leu 
             900                905                910
Leu Arg Phe Tyr Val His Val Leu Gln Lys Glu Leu Ala Ala Ser Ala 
         915                920                925
Ser Glu Asp Thr His Pro Tyr Lys Glu Glu Leu Glu Thr Ala Leu Glu 
     930                935                940
Gln Cys Phe Tyr Cys Leu Tyr Ser Phe Pro Ser Lys Lys Ser Lys Ala 
 945                950                955                960
Arg Tyr Leu Glu Glu His Ser Ala Gln Gln Val Asp Leu Thr Trp Glu 
                 965                970                975
Asp Ala Leu Phe Met Phe Glu Tyr Phe Lys Pro Lys Thr Leu Pro Glu 
             980                985                990
Phe Asp Ser Tyr Lys Thr Ser Thr Val Ser Ala Asp Leu Ala Asn Leu 
         995                1000                1005
Leu Lys Arg Ile Ala Thr Ile Val Pro Arg Thr Glu Lys Pro Ala Leu 
     1010                1015                1020
Ser Met Asp Lys Val Ser Ala Tyr Ile Glu Gly Thr Ser Ala Glu Val 
 1025                1030                1035                1040
Pro Cys Leu Pro Asp Gly Ala Asp Pro Ala Pro Pro Val Leu Asn Glu 
                 1045                1050                1055
Leu Tyr Tyr Leu Leu Ala Asp Tyr His Phe Lys Asn Lys Glu Gln Ser 
             1060                1065                1070
Lys Ala Ile Lys Phe Tyr Met His Asp Ile Cys Ile Cys Pro Asn Arg 
         1075                1080                1085
Phe Asp Ser Trp Ala Gly Met Ala Leu Ala Arg Ala Ser Arg Ile Gln 
     1090                1095                1100
Asp Lys Leu Asn Ser Asn Glu Leu Lys Ser Asp Gly Pro Ile Trp Arg 
 1105                1110                1115                1120
His Ala Thr Pro Val Leu Asn Cys Phe Arg Arg Ala Leu Glu Ile Asp 
                 1125                1130                1135
Ser Ser Asn Leu Ser Leu Trp Ile Glu Tyr Gly Thr Met Ser Tyr Ala 
             1140                1145                1150
Leu His Ser Phe Ala Ser Arg Gln Leu Lys Gln Trp Arg Ala Glu Leu 
         1155                1160                1165
Pro Pro Glu Val Val Gln Gln Met Glu Asp Arg Arg Asp Ser Met Leu 
     1170                1175                1180
Glu Thr Ala Arg His Cys Phe Thr Ser Ala Ala His Cys Glu Gly Asp 
 1185                1190                1195                1200
Gly Asp Glu Glu Glu Trp Leu Ile His Tyr Met Leu Gly Lys Val Ala 
                 1205                1210                1215
Glu Lys Gln Gln Gln Pro Pro Thr Val Tyr Leu Leu His Tyr Arg Gln 
             1220                1225                1230
Ala Gly His Tyr Leu His Glu Glu Ala Ala Arg Tyr Pro Lys Lys Ile 
         1235                1240                1245
His Tyr His Asn Pro Pro Glu Leu Ala Met Glu Ala Leu Glu Val Tyr 
     1250                1255                1260
Phe Arg Leu His Ala Ser Ile Leu Lys Leu Leu Gly Lys Pro Asp Ser 
 1265                1270                1275                1280
Gly Val Ser Ala Glu Val Leu Val Ser Phe Met Lys Glu Ala Ala Glu 
                 1285                1290                1295
Gly Pro Phe Ala Arg Gly Glu Glu Lys Asn Thr Pro Lys Ala Ser Glu 
             1300                1305                1310
Lys Glu Lys Ala Cys Leu Val Asp Glu Asp Ser His Ser Ser Ala Gly 
         1315                1320                1325
Thr Leu Pro Gly Pro Gly Ala Ser Leu Pro Ser Ser Ser Gly Pro Gly 
     1330                1335                1340
Leu Thr Ser Pro Pro Tyr Thr Ala Thr Pro Ile Asp His Asp Tyr Val 
 1345                1350                1355                1360
Lys Cys Lys Lys Pro Arg Gln Gln Ala Thr Pro Asp Asp Arg Ser Gln 
                 1365                1370                1375
Asp Ser Thr Ala Val Ala Leu Ser Asp Ser Ser Ser Thr Gln Asp Phe 
             1380                1385                1390
Phe Asn Glu Pro Thr Ser Leu Leu Asp Gly Ser Arg Lys Leu Leu Pro 
         1395                1400                1405
Glu Lys Arg Ile Ser Gly Leu Ser Ala Gln Ala Gly Pro Ser Gly Lys 
     1410                1415                1420
Asp Leu Pro Gly Pro Thr Glu Glu Arg Gly Lys Thr Glu Glu Ser Leu 
 1425                1430                1435                1440
Glu Ser Thr Glu Ala Phe Arg Val Val Glu Pro Ser Val Gln Lys Pro 
                 1445                1450                1455
Val Ala Asp Ser Ser Ala Ser Ala Tyr Ile Pro Ser Lys Pro Ala Val 
             1460                1465                1470
Ser Thr Pro Pro Pro Trp Asp Gly Lys Lys Arg Ser Asp Pro Leu Gly 
         1475                1480                1485
Glu Pro Val Ala Phe Pro Gln Gly Leu Pro Ala Gly Ala Glu Glu Gln 
     1490                1495                1500
Arg Gln Phe Leu Thr Glu Gln Cys Ile Ala Ser Phe Cys Leu Cys Leu 
 1505                1510                1515                1520
Ser Arg Phe Pro Gln His Tyr Lys Ser Leu Tyr Arg Leu Ala Phe Leu 
                 1525                1530                1535
Tyr Thr Tyr Ser Lys Thr His Arg Asn Leu Gln Trp Ala Arg Asp Val 
             1540                1545                1550
Leu Leu Gly Ser Ser Ile Pro Trp Gln Gln Leu Gln His Met Pro Ala 
         1555                1560                1565
Gln Gly Leu Phe Cys Glu Arg Asn Lys Thr Asn Phe Phe Asn Gly Ile 
     1570                1575                1580
Trp Arg Ile Pro Val Asp Glu Ile Asp Arg Pro Gly Ser Phe Ala Trp 
 1585                1590                1595                1600
His Met Asn Arg Ser Ile Val Leu Leu Leu Lys Val Leu Ala Gln Leu 
                 1605                1610                1615
Arg Asp His Ser Thr Leu Leu Lys Val Ser Ser Met Leu Gln Arg Thr 
             1620                1625                1630
Pro Asp Gln Gly Lys Lys Tyr Leu Arg Asp Ala Asp Arg Gln Val Leu 
         1635                1640                1645
Ala Gln Arg Ala Phe Ile Leu Thr Val Lys Val Leu Glu Asp Thr Leu 
     1650                1655                1660
Ser Glu Leu Ala Glu Gly Leu Glu His Pro Gly Ser Lys Ala Cys Gly 
 1665                1670                1675                1680
Leu Ser Gly Ala Arg Met Thr Thr Asp Val Ser His Lys Ala Ser Pro 
                 1685                1690                1695
Glu Asp Gly Gln Glu Ser Leu Pro His Pro Lys Lys Leu Pro Leu Ala 
             1700                1705                1710
Asp Gly Ser Gly Pro Gly Pro Glu Pro Gly Gly Lys Val Gly Pro Leu 
         1715                1720                1725
His Gln Leu Pro Val Ala Thr Asp Thr Arg Asp Asn Thr Glu Gln Gly 
     1730                1735                1740
Gly Glu Pro Lys Asp Lys Glu Arg Pro Pro Val Gly Pro Thr Glu Pro 
 1745                1750                1755                1760
Met Asp Thr Gly Glu Thr Ala Ala Arg His Pro Asp Leu Glu Pro Thr 
                 1765                1770                1775
Pro Arg Leu Leu Pro Gly Arg Pro Pro Arg Asp Arg Gly Pro Glu Ser 
             1780                1785                1790
Arg Ser Ala Glu Leu Ser Leu Glu Glu Leu Ser Ile Ser Thr Arg Gln 
         1795                1800                1805
Gln Pro Ala Pro Leu Val Pro Ser Pro Val Thr Pro Thr Thr Ala Ala 
     1810                1815                1820
Pro Thr Thr Met Gly Ala Arg Ala Ala Gly His Pro Glu Glu Ala Pro 
 1825                1830                1835                1840
Pro Arg Pro Asn Arg Lys Arg Lys Leu Leu Gln Asp Thr Glu Ser Gly 
                 1845                1850                1855
Lys Thr Leu Leu Leu Asp Ala Tyr Arg Val Trp Gln Gln Gly Gln Lys 
             1860                1865                1870
Ala Met Ala Tyr Asp Leu Ser Arg Ile Glu Lys Ile Met Ser Glu Thr 
         1875                1880                1885
Tyr Met Leu Ile Lys Gln Val Asp Glu Glu Thr Ala Leu Glu Gln Ala 
     1890                1895                1900
Val Lys Phe Cys Gln Val His Leu Gly Ala Ala Ala Gln Arg Gln Ala 
 1905                1910                1915                1920
Ser Gly Asp Ala Pro Thr Thr Pro Lys His Pro Lys Asp Ser Arg Glu 
                 1925                1930                1935
Asn Phe Phe Pro Ala Thr Val Ala Pro Ser Ala Pro Asp Thr Thr Ala 
             1940                1945                1950
Pro Asp Ala Leu Gln Arg Pro Ser Asp Ser His Leu Lys Pro Gly Leu 
         1955                1960                1965
Ala Ala Ala Ile Thr Cys Pro Pro Ser Ala Ser Ala Ser Thr Pro Asp 
     1970                1975                1980
Pro Gly Ile Pro Gln Pro His Arg Pro Glu Ala Val Pro Ser Arg Ala 
 1985                1990                1995                2000
Pro Leu Ser Pro Asp Gly Glu Glu Val Ser Gly Val Thr Glu Gly Pro 
                 2005                2010                2015
Ser Phe Leu Ser Gln Glu Pro Arg His Ser His Gln Met Lys Met Ala 
             2020                2025                2030
Ala Thr Gly Pro Leu Ala Glu Gln His Cys Trp Pro Val Glu Ala Ala 
         2035                2040                2045
Cys Gln Thr Gly Ala Glu Pro Thr Phe Ser Gln Ala Thr Ser Thr Lys 
     2050                2055                2060
Val Pro Ser Ser Gly Ser Thr Gln Thr Pro Glu Ser His Gln Gly Lys 
 2065                2070                2075                2080
Thr Glu Ser Ser Arg Ala Lys Ser Arg Leu Leu Pro Asn Met Pro Lys 
                 2085                2090                2095
Leu Val Ile Pro Ser Ala Thr Thr Lys Phe Pro Pro Glu Ile Thr Val 
             2100                2105                2110
Thr Pro Pro Thr Pro Thr Leu Leu Ser Pro Lys Gly Ser Ile Ser Glu 
         2115                2120                2125
Glu Thr Lys Gln Lys Leu Lys Ser Ala Ile Leu Ser Ala Gln Ser Ala 
     2130                2135                2140
Ala Asn Val Arg Lys Glu Ser Leu Cys Gln Pro Ala Leu Glu Val Leu 
 2145                2150                2155                2160
Glu Thr Ser Ser Gln Glu Ser Ser Leu Glu Ser Glu Thr Asp Glu Asp 
                 2165                2170                2175
Asp Asp Phe Met Asp Val 
             2180



<210> 934
<211> 6143
<212> DNA
<213> Homo sapiens
<308> AB002328
<400> 934

cagttaacg  gatccagcc  agcactgtc  gcaccaacc  agctgtggc  gtcgccgag  60
ctgtggtct  ctacacctc  gtggctaca  ccagcttcc  actgcacag  cctggtctg  120
tggagacag  cgctcctgt  ggtgatatt  ctgggggag  taaatccaa  aaaggggta  180
aacggaaga  gatttcaga  gagagtgga  aaacagcaa  gcggcggtc  gcccgtgtc  240
gaaacacca  gtgcaaaaa  gaagagaaa  tagacttcc  ggagcttct  atgaagttc  300
tgccgtcca  gttaagaaa  ctggaccct  aggaggaag  tgattcctt  aataactat  360
aagtccagt  agaagccaa  ctggaaagc  tcccaagca  tgggcctca  aggctgtca  420
ttgactcag  cacattcat  gaatctgaa  agcaggacg  gcatgagtt  ctgctggag  480
acctaacca  cgggggcat  ctggagctg  tgatgcgct  cctgaaagc  atgggccac  540
agttcttgg  aaggtggcc  ccaggcttg  cggaggtcg  gctcagcgt  taccacagc  600
ggaggaggc  cagcaccag  ctgcccaac  cgctgctga  ggactgcag  aacaagcac  660
tcaaggaca  gatgctgat  tctctctcc  gcatggaac  ccagctgga  cagtggctg  720
tgaccaaag  cagaagctc  gcagtgtct  ctcggaact  ccctgctgg  atggtgaat  780
gcagatttg  acctgactt  ccagggacc  actgcctgg  tgacctcct  cagctgtca  840
ttgcctcgt  ccagcgcga  ctgttcgag  atggttggc  ggagtttgt  gtccgtgtt  900
actggctga  ggctcgctt  ctggcgctg  agggagaca  ggagcaggc  ctggagaac  960
atgacatct  cacagaaat  ctccagagt  ccaccgcca  ccaggtgga  gcaggggct  1020
aacgaagag  cattgtcat  cggctgccc  acctccata  tgactctgt  gtttccctg  1080
aggagattg  taagaacct  aagtcgctg  agcggtgcc  gtccctgga  gagattcag  1140
ggctgtatg  agcaggcga  tacaaggct  ttgtgcatc  gctccgccc  actttgtgc  1200
ccagtgggt  tgaccgggc  aaacacctg  agtttatga  ttccattcc  gagaggcca  1260
cccagctgc  tcttctgca  gactccttg  tccggctga  ggactatcg  cagtgtttt  1320
agtgttccg  tgtggctct  aacgaggct  tccagcaga  ggtgaactc  ggtgaggct  1380
ccgccaagg  ggagtgggt  gccacagtg  cccaactgc  gatgggcat  gagcaggcc  1440
tctctgcgg  cagcagtgg  agcatcctg  aggtatcat  ctccaccac  ggccttgtg  1500
ggctcacca  caacctcat  caggtcatt  actgcagca  ggctgtgca  gaggaggcc  1560
aggagcccc  cgtctcttc  gtgctaccc  ggatcattc  acaccggat  atctggcag  1620
aggaagaca  cttccattc  ctgtgccac  agcagcagc  ccaaaaccc  gcggaggaa  1680
ggatgtcag  gacgcccat  ctcccatcc  ccctcatgc  gctgaacac  gcccacgag  1740
atttgggca  aaggtcctg  tgctgcaat  cagatgggg  tctgctgcg  ttctatgtg  1800
gagtactcc  gaaggaact  gctgcatcc  cctctgaag  cacgcaccc  tacaaggag  1860
agctggaga  agccttgga  cagtgcttc  actgcctgt  cagcttccc  agcaagaag  1920
gtaaggcca  gtacctgga  gaacactcg  cccagcagg  ggatcttat  tgggaggat  1980
cactgttca  gtttgagta  tttaagccc  agacccttc  tgaatttga  agctataag  2040
ccagcaccg  gtctgctga  ttggccaac  tactgaaga  aattgccac  attgtgcct  2100
gcacagaga  gccagccct  agcctggac  aagtctctg  ctacattga  ggaacttca  2160
ctgaggtac  ctgcctccc  gagggggct  acccctccc  tccagtggt  aacgagctt  2220
actacctcc  ggctgatta  catttcaaa  acaaggagc  gtccaaggc  atcaagttc  2280
acatgcatg  catctgcat  tgccccaat  ggtttgatt  ctgggcagg  atggctctg  2340
cccgggcca  ccgcattca  gacaagctg  actccaatg  gctgaagag  gatgggccc  2400
tttggaagc  tgccacgcc  gtcttgaac  gcttccgtc  ggccctgga  attgacagc  2460
ccaacttgt  cctatggat  gagtatggc  ccatgtcct  tgccttgca  tcattcgcc  2520
cacgtcaat  gaagcagtg  agaggcgag  tgccccctg  gctcgtgca  cagatggag  2580
gccggcgcg  cagcatgct  gagacagcc  agcactgtt  cacatcagc  gcccgctgc  2640
agggtgatg  tgacgagga  gagtggctc  tccactaca  gctgggcaa  gtggctgag  2700
agcagcagc  gccacccac  gtttacttg  tgcactaca  gcaggctgg  cactacctg  2760
acgaggagg  tgcccgcta  cccaagaag  tccactacc  caacccacc  gagctggcc  2820
tggaggccc  ggaggtgta  tttcggctc  atgcttcca  cctgaagct  ctggggaag  2880
ccgattctg  ggttggtgc  gaggtcctg  tcaacttta  gaaggaggc  gcagaagga  2940
cctttgcca  gggcgagga  aagaacaca  ccaaagctt  agaaaagga  aaggcctgc  3000
tggtggacg  ggactccca  tcttcagct  ggacactgc  gggccccgg  gcctccctc  3060
cctcctcct  tggcccagg  ctgacatcc  caccttaca  agccactcc  attgaccac  3120
attacgtca  atgtaaaaa  ccccaccag  aggcaacgc  ggacgaccg  agccaggac  3180
gcacagccg  agcactctc  gactctagc  caacgcagg  cttctttaa  gagcccacc  3240
gcttactgg  aggctccag  aaatcctac  cagagaaga  gctgcccat  ctcagttcc  3300
aagcaggag  gacgggtaa  gatcttcag  gggccacag  agaaagagg  aaaaacgag  3360
agtcattgg  gagtacaga  ggcttccgg  ctgcagagc  aggtgtcca  aagcctgct  3420
cagaaaccc  agcctctgc  tgcatccct  gcaagccct  agcatccac  cccaccctg  3480
gggatggga  gaagagagg  gacctccca  gggagccag  ggccttccc  caggggctg  3540
cggctggtg  tgaggagca  cggcagttt  tcacagagc  gtgcatcgc  tccttccgc  3600
tgtgcctga  ccgcttccc  cagcactat  agagtctct  ccgtctggc  ttcctctac  3660
cctacagca  gacccaccg  aacctccag  gggcccgcg  cgtgttgct  ggcagcagt  3720
tcccgtggc  acaactgca  cacatgccg  cacaggggc  cttctgcga  aggaacaag  3780
ccaatttct  caacggcat  tggcggatc  ccgtggacg  gattgaccg  ccgggcagc  3840
ttgcctggc  catgaaccg  tccatcgtg  tgctgctca  ggtgctggc  cagctgcgg  3900
accacagca  cctgctgaa  gtgtcctcc  tgcttcagc  gaccccaga  cagggcaag  3960
agtatctgc  agatgctga  cgccaggtc  tggcgcagc  ggccttcat  ctcactgtg  4020
aggtgctcg  agacacgct  agcgagctc  cagaggggt  agaacgccc  gggcccaag  4080
tctgtggcc  ccccggagc  aggatgacc  ccgatgtct  acacaaggc  agtcctgag  4140
atggccagg  gggcctccc  cagccgaag  agccccctc  ggctgatgg  tcagggcca  4200
ggcccgagc  aggaggcaa  gtgggcctc  tcaaccacc  gcctgtggc  atggatgca  4260
gagacagtg  agaccaaag  ggggagcgg  aggataaag  gagcccacg  gcagggccc  4320
ctgagccca  ggacacgag  gaggccact  tttgccact  agacttgga  cggacacca  4380
ccctgctgc  aggtcgccc  gcaagggac  ggggccccg  gagccggcc  actgagctg  4440
ccctggagg  gctgagcat  agtgcccgg  agcagccca  cccgctcac  ccagcccag  4500
cagcccccg  ccccgcccc  gccaccacc  cagggacca  ggcaggggg  cacccggag  4560
agccgctct  ccggctcag  cgcaagagg  agctcctgg  ggacacaga  tcaggcaag  4620
cacttctgt  ggatgccta  cgtgtgtgg  agcagggcc  gaagggtgt  gcctatgac  4680
tgggccgtg  ggagaggat  atgtcggag  cctacatgc  catcaagca  gtggatgag  4740
aggctgcgc  ggagcaggc  gtgaagttc  gccaggtcc  tcttggggc  gccgcccag  4800
gacaggcct  gggggacac  cccaccact  caaagcacc  caaagacag  cgagagaac  4860
tctttcctg  gacagtggt  cccacagcc  ctgaccctg  gccagctga  tctgtccag  4920
ggcccagtg  tgctcacac  aagcctcgc  ctgcactag  tgccgccac  actattatc  4980
cctgccctc  gtcagcatc  gcttccacc  tggaccagt  caaggaccc  gggcctccc  5040
ggccacaca  gcctgaagc  acccccagc  tggcctctc  gggcccaga  ggagaagag  5100
tggcgagag  ggcagaggg  accagcttc  cgcctcagg  gccacggca  agtccgcag  5160
tgaagatgg  ccccacaag  tccccggca  agccacact  ctggccggc  gaggctgcc  5220
tgggcacag  cgctgagcc  acctgcagc  aggagggga  actgaggcc  gagccgaga  5280
gggatgggg  ggctcagga  gctgcgagt  agactcagc  cctgagctc  cccccaaca  5340
ctgccagct  caaggcccc  agcagtggg  gtgcccagc  accagaggg  cacccaggc  5400
agcctgagc  cagccgggc  aagtcccgc  ccctgccca  catgccaaa  ctggtcatc  5460
cctccgccg  caccaagtt  ccccctgag  tcaccgtca  gccacccac  ccaaccctg  5520
tctccccca  aggcagcat  tcggaggag  ccaagcaga  gctgaagtc  gccatcctt  5580
ctgcccagt  tgctgccaa  gtgaggaag  agagcctat  ccagccagc  ctggaggtc  5640
tggagacat  cagccagga  tcctcgctg  agagcgaga  agacgagga  gacgactac  5700
tggacattt  aggggccac  gcagcccca  cgccacgcc  caggggacc  gccaggcct  5760
gaatgcccc  tgggcagga  cctgggcag  accagaggc  cacatggat  ccactcccc  5820
cacagcccc  aggcctgcc  agcccacct  ctcatggca  cctccctgt  cccaggtca  5880
gctgtccac  ccacatggg  gcccagagg  ggaggggcc  gccttagcc  tgtgaaggt  5940
gattggtcg  catctgcac  ccaggcggc  tccttttct  tgaagtgtt  actttgtaa  6000
tctgcccac  cccagctgg  catatccac  cctcgacgc  gggatgagc  ggctctgcc  6060
gtgtcacag  ggaggggtc  tttagggcc  ggctcaccc  tcacccttt  tttggttgc  6120
tttctaata  agatggaac  gtt  6143



<210> 935
<211> 2220
<212> PRT
<213> Homo sapiens
<308> Q9Y6J0
<400> 935

Met Ile Arg Ile Ala Ala Leu Asn Ala Ser Ser Thr Ile Glu Asp Asp 
  1               5                  10                  15
His Glu Gly Ser Phe Lys Ser His Lys Thr Gln Thr Lys Glu Ala Gln 
             20                  25                  30
Glu Ala Glu Ala Phe Ala Leu Tyr His Lys Ala Leu Asp Leu Gln Lys 
         35                  40                  45
His Asp Arg Phe Glu Glu Ser Ala Lys Ala Tyr His Glu Leu Leu Glu 
     50                  55                  60
Ala Ser Leu Leu Arg Glu Ala Val Ser Ser Gly Asp Glu Lys Glu Gly 
 65                  70                  75                  80
Leu Lys His Pro Gly Leu Ile Leu Lys Tyr Ser Thr Tyr Lys Asn Leu 
                 85                  90                  95
Ala Gln Leu Ala Ala Gln Arg Glu Asp Leu Glu Thr Ala Met Glu Phe 
             100                105                110
Tyr Leu Glu Ala Val Met Leu Asp Ser Thr Asp Val Asn Leu Trp Tyr 
         115                120                125
Lys Ile Gly His Val Ala Leu Arg Leu Ile Arg Ile Pro Leu Ala Arg 
     130                135                140
His Ala Phe Glu Glu Gly Leu Arg Cys Asn Pro Asp His Trp Pro Cys 
 145                150                155                160
Leu Asp Asn Leu Ile Thr Val Leu Tyr Thr Leu Ser Asp Tyr Thr Thr 
                 165                170                175
Cys Leu Tyr Phe Ile Cys Lys Ala Leu Glu Lys Asp Cys Arg Tyr Ser 
             180                185                190
Lys Gly Leu Val Leu Lys Glu Lys Ile Phe Glu Glu Gln Pro Cys Leu 
         195                200                205
Arg Lys Asp Ser Leu Arg Met Phe Leu Lys Cys Asp Met Ser Ile His 
     210                215                220
Asp Val Ser Val Ser Ala Ala Glu Thr Gln Ala Ile Val Asp Glu Ala 
 225                230                235                240
Leu Gly Leu Arg Lys Lys Arg Gln Ala Leu Ile Val Arg Glu Lys Glu 
                 245                250                255
Pro Asp Leu Lys Leu Val Gln Pro Ile Pro Phe Phe Thr Trp Lys Cys 
             260                265                270
Leu Gly Glu Ser Leu Leu Ala Met Tyr Asn His Leu Thr Thr Cys Glu 
         275                280                285
Pro Pro Arg Pro Ser Leu Gly Lys Arg Ile Asp Leu Ser Asp Tyr Gln 
     290                295                300
Asp Pro Ser Gln Pro Leu Glu Ser Ser Met Val Val Thr Pro Val Asn 
 305                310                315                320
Val Ile Gln Pro Ser Thr Val Ser Thr Asn Pro Ala Val Ala Val Ala 
                 325                330                335
Glu Pro Val Val Ser Tyr Thr Ser Val Ala Thr Thr Ser Phe Pro Leu 
             340                345                350
His Ser Pro Gly Leu Leu Glu Thr Gly Ala Pro Val Gly Asp Ile Ser 
         355                360                365
Gly Gly Asp Lys Ser Lys Lys Gly Val Lys Arg Lys Lys Ile Ser Glu 
     370                375                380
Glu Ser Gly Glu Thr Ala Lys Arg Arg Ser Ala Arg Val Arg Asn Thr 
 385                390                395                400
Lys Cys Lys Lys Glu Glu Lys Val Asp Phe Gln Glu Leu Leu Met Lys 
                 405                410                415
Phe Leu Pro Ser Arg Leu Arg Lys Leu Asp Pro Glu Glu Glu Asp Asp 
             420                425                430
Ser Phe Asn Asn Tyr Glu Val Gln Ser Glu Ala Lys Leu Glu Ser Phe 
         435                440                445
Pro Ser Ile Gly Pro Gln Arg Leu Ser Phe Asp Ser Ala Thr Phe Met 
     450                455                460
Glu Ser Glu Lys Gln Asp Val His Glu Phe Leu Leu Glu Asn Leu Thr 
 465                470                475                480
Asn Gly Gly Ile Leu Glu Leu Met Met Arg Tyr Leu Lys Ala Met Gly 
                 485                490                495
His Lys Phe Leu Val Arg Trp Pro Pro Gly Leu Ala Glu Val Val Leu 
             500                505                510
Ser Val Tyr His Ser Trp Arg Arg His Ser Thr Ser Leu Pro Asn Pro 
         515                520                525
Leu Leu Arg Asp Cys Ser Asn Lys His Ile Lys Asp Met Met Leu Met 
     530                535                540
Ser Leu Ser Cys Met Glu Leu Gln Leu Asp Gln Trp Leu Leu Thr Lys 
 545                550                555                560
Gly Arg Ser Ser Ala Val Ser Pro Arg Asn Cys Pro Ala Gly Met Val 
                 565                570                575
Asn Gly Arg Phe Gly Pro Asp Phe Pro Gly Thr His Cys Leu Gly Asp 
             580                585                590
Leu Leu Gln Leu Ser Phe Ala Ser Ser Gln Arg Asp Leu Phe Glu Asp 
         595                600                605
Gly Trp Leu Glu Phe Val Val Arg Val Tyr Trp Leu Lys Ala Arg Phe 
     610                615                620
Leu Ala Leu Gln Gly Asp Met Glu Gln Ala Leu Glu Asn Tyr Asp Ile 
 625                630                635                640
Cys Thr Glu Met Leu Gln Ser Ser Thr Ala Ile Gln Val Glu Ala Gly 
                 645                650                655
Ala Glu Arg Arg Asp Ile Val Ile Arg Leu Pro Asn Leu His Asn Asp 
             660                665                670
Ser Val Val Ser Leu Glu Glu Ile Asp Lys Asn Leu Lys Ser Leu Glu 
         675                680                685
Arg Cys Gln Ser Leu Glu Glu Ile Gln Arg Leu Tyr Glu Ala Gly Asp 
     690                695                700
Tyr Lys Ala Val Val His Leu Leu Arg Pro Thr Leu Cys Thr Ser Gly 
 705                710                715                720
Phe Asp Arg Ala Lys His Leu Glu Phe Met Thr Ser Ile Pro Glu Arg 
                 725                730                735
Pro Ala Gln Leu Leu Leu Leu Gln Asp Ser Leu Leu Arg Leu Lys Asp 
             740                745                750
Tyr Arg Gln Cys Phe Glu Cys Ser Asp Val Ala Leu Asn Glu Ala Val 
         755                760                765
Gln Gln Met Val Asn Ser Gly Glu Ala Ala Ala Lys Glu Glu Trp Val 
     770                775                780
Ala Thr Val Thr Gln Leu Leu Met Gly Ile Glu Gln Ala Leu Ser Ala 
 785                790                795                800
Asp Ser Ser Gly Ser Ile Leu Lys Val Ser Ser Ser Thr Thr Gly Leu 
                 805                810                815
Val Arg Leu Thr Asn Asn Leu Ile Gln Val Ile Asp Cys Ser Met Ala 
             820                825                830
Val Gln Glu Glu Ala Lys Glu Pro His Val Ser Ser Val Leu Pro Trp 
         835                840                845
Ile Ile Leu His Arg Ile Ile Trp Gln Glu Glu Asp Thr Phe His Ser 
     850                855                860
Leu Cys His Gln Gln Gln Leu Gln Asn Pro Ala Glu Glu Gly Met Ser 
 865                870                875                880
Glu Thr Pro Met Leu Pro Ser Ser Leu Met Leu Leu Asn Thr Ala His 
                 885                890                895
Glu Tyr Leu Gly Arg Arg Ser Trp Cys Cys Asn Ser Asp Gly Ala Leu 
             900                905                910
Leu Arg Phe Tyr Val Arg Val Leu Gln Lys Glu Leu Ala Ala Ser Thr 
         915                920                925
Ser Glu Asp Thr His Pro Tyr Lys Glu Glu Leu Glu Thr Ala Leu Glu 
     930                935                940
Gln Cys Phe Tyr Cys Leu Tyr Ser Phe Pro Ser Lys Lys Ser Lys Ala 
 945                950                955                960
Arg Tyr Leu Glu Glu His Ser Ala Gln Gln Val Asp Leu Ile Trp Glu 
                 965                970                975
Asp Ala Leu Phe Met Phe Glu Tyr Phe Lys Pro Lys Thr Leu Pro Glu 
             980                985                990
Phe Asp Ser Tyr Lys Thr Ser Thr Val Ser Ala Asp Leu Ala Asn Leu 
         995                1000                1005
Leu Lys Arg Ile Ala Thr Ile Val Pro Arg Thr Glu Arg Pro Ala Leu 
     1010                1015                1020
Ser Leu Asp Lys Val Ser Ala Tyr Ile Glu Gly Thr Ser Thr Glu Val 
 1025                1030                1035                1040
Pro Cys Leu Pro Glu Gly Ala Asp Pro Ser Pro Pro Val Val Asn Glu 
                 1045                1050                1055
Leu Tyr Tyr Leu Leu Ala Asp Tyr His Phe Lys Asn Lys Glu Gln Ser 
             1060                1065                1070
Lys Ala Ile Lys Phe Tyr Met His Asp Ile Cys Ile Cys Pro Asn Arg 
         1075                1080                1085
Phe Asp Ser Trp Ala Gly Met Ala Leu Ala Arg Ala Ser Arg Ile Gln 
     1090                1095                1100
Asp Lys Leu Asn Ser Asn Glu Leu Lys Ser Asp Gly Pro Ile Trp Lys 
 1105                1110                1115                1120
His Ala Thr Pro Val Leu Asn Cys Phe Arg Arg Ala Leu Glu Ile Asp 
                 1125                1130                1135
Ser Ser Asn Leu Ser Leu Trp Ile Glu Tyr Gly Thr Met Ser Tyr Ala 
             1140                1145                1150
Leu His Ser Phe Ala Ser Arg Gln Leu Lys Gln Trp Arg Gly Glu Leu 
         1155                1160                1165
Pro Pro Glu Leu Val Gln Gln Met Glu Gly Arg Arg Asp Ser Met Leu 
     1170                1175                1180
Glu Thr Ala Lys His Cys Phe Thr Ser Ala Ala Arg Cys Glu Gly Asp 
 1185                1190                1195                1200
Gly Asp Glu Glu Glu Trp Leu Ile His Tyr Met Leu Gly Lys Val Ala 
                 1205                1210                1215
Glu Lys Gln Gln Gln Pro Pro Thr Val Tyr Leu Leu His Tyr Arg Gln 
             1220                1225                1230
Ala Gly His Tyr Leu His Glu Glu Ala Ala Arg Tyr Pro Lys Lys Ile 
         1235                1240                1245
His Tyr His Asn Pro Pro Glu Leu Ala Met Glu Ala Leu Glu Val Tyr 
     1250                1255                1260
Phe Arg Leu His Ala Ser Ile Leu Lys Leu Leu Gly Lys Pro Asp Ser 
 1265                1270                1275                1280
Gly Val Gly Ala Glu Val Leu Val Asn Phe Met Lys Glu Ala Ala Glu 
                 1285                1290                1295
Gly Pro Phe Ala Arg Gly Glu Glu Lys Asn Thr Pro Lys Ala Ser Glu 
             1300                1305                1310
Lys Glu Lys Ala Cys Leu Val Asp Glu Asp Ser His Ser Ser Ala Gly 
         1315                1320                1325
Thr Leu Pro Gly Pro Gly Ala Ser Leu Pro Ser Ser Ser Gly Pro Gly 
     1330                1335                1340
Leu Thr Ser Pro Pro Tyr Thr Ala Thr Pro Ile Asp His Asp Tyr Val 
 1345                1350                1355                1360
Lys Cys Lys Lys Pro His Gln Gln Ala Thr Pro Asp Asp Arg Ser Gln 
                 1365                1370                1375
Asp Ser Thr Ala Val Ala Leu Ser Asp Ser Ser Ser Thr Gln Asp Phe 
             1380                1385                1390
Phe Asn Glu Pro Thr Ser Leu Leu Glu Gly Ser Arg Lys Ser Tyr Thr 
         1395                1400                1405
Glu Lys Arg Leu Pro Ile Leu Ser Ser Gln Ala Gly Ala Thr Gly Lys 
     1410                1415                1420
Asp Leu Gln Gly Ala Thr Glu Glu Arg Gly Lys Asn Glu Glu Ser Leu 
 1425                1430                1435                1440
Glu Ser Thr Glu Gly Phe Arg Ala Ala Glu Gln Gly Val Gln Lys Pro 
                 1445                1450                1455
Ala Ala Glu Thr Pro Ala Ser Ala Cys Ile Pro Gly Lys Pro Ser Ala 
             1460                1465                1470
Ser Thr Pro Thr Leu Trp Asp Gly Lys Lys Arg Gly Asp Leu Pro Gly 
         1475                1480                1485
Glu Pro Val Ala Phe Pro Gln Gly Leu Pro Ala Gly Ala Glu Glu Gln 
     1490                1495                1500
Arg Gln Phe Leu Thr Glu Gln Cys Ile Ala Ser Phe Arg Leu Cys Leu 
 1505                1510                1515                1520
Ser Arg Phe Pro Gln His Tyr Lys Ser Leu Tyr Arg Leu Ala Phe Leu 
                 1525                1530                1535
Tyr Thr Tyr Ser Lys Thr His Arg Asn Leu Gln Trp Ala Arg Asp Val 
             1540                1545                1550
Leu Leu Gly Ser Ser Ile Pro Trp Gln Gln Leu Gln His Met Pro Ala 
         1555                1560                1565
Gln Gly Leu Phe Cys Glu Arg Asn Lys Thr Asn Phe Phe Asn Gly Ile 
     1570                1575                1580
Trp Arg Ile Pro Val Asp Glu Ile Asp Arg Pro Gly Ser Phe Ala Trp 
 1585                1590                1595                1600
His Met Asn Arg Ser Ile Val Leu Leu Leu Lys Val Leu Ala Gln Leu 
                 1605                1610                1615
Arg Asp His Ser Thr Leu Leu Lys Val Ser Ser Met Leu Gln Arg Thr 
             1620                1625                1630
Pro Asp Gln Gly Lys Lys Tyr Leu Arg Asp Ala Asp Arg Gln Val Leu 
         1635                1640                1645
Ala Gln Arg Ala Phe Ile Leu Thr Val Lys Val Leu Glu Asp Thr Leu 
     1650                1655                1660
Ser Glu Leu Ala Glu Gly Ser Glu Arg Pro Gly Pro Lys Val Cys Gly 
 1665                1670                1675                1680
Leu Pro Gly Ala Arg Met Thr Thr Asp Val Ser His Lys Ala Ser Pro 
                 1685                1690                1695
Glu Asp Gly Gln Glu Gly Leu Pro Gln Pro Lys Lys Pro Pro Leu Ala 
             1700                1705                1710
Asp Gly Ser Gly Pro Gly Pro Glu Pro Gly Gly Lys Val Gly Leu Leu 
         1715                1720                1725
Asn His Arg Pro Val Ala Met Asp Ala Gly Asp Ser Ala Asp Gln Ser 
     1730                1735                1740
Gly Glu Arg Lys Asp Lys Glu Ser Pro Arg Ala Gly Pro Thr Glu Pro 
 1745                1750                1755                1760
Met Asp Thr Ser Glu Ala Thr Val Cys His Ser Asp Leu Glu Arg Thr 
                 1765                1770                1775
Pro Pro Leu Leu Pro Gly Arg Pro Ala Arg Asp Arg Gly Pro Glu Ser 
             1780                1785                1790
Arg Pro Thr Glu Leu Ser Leu Glu Glu Leu Ser Ile Ser Ala Arg Gln 
         1795                1800                1805
Gln Pro Thr Pro Leu Thr Pro Ala Gln Pro Ala Pro Ala Pro Ala Pro 
     1810                1815                1820
Ala Thr Thr Thr Gly Thr Arg Ala Gly Gly His Pro Glu Glu Pro Leu 
 1825                1830                1835                1840
Ser Arg Leu Ser Arg Lys Arg Lys Leu Leu Glu Asp Thr Glu Ser Gly 
                 1845                1850                1855
Lys Thr Leu Leu Leu Asp Ala Tyr Arg Val Trp Gln Gln Gly Gln Lys 
             1860                1865                1870
Gly Val Ala Tyr Asp Leu Gly Arg Val Glu Arg Ile Met Ser Glu Thr 
         1875                1880                1885
Tyr Met Leu Ile Lys Gln Val Asp Glu Glu Ala Ala Leu Glu Gln Ala 
     1890                1895                1900
Val Lys Phe Cys Gln Val His Leu Gly Ala Ala Ala Gln Arg Gln Ala 
 1905                1910                1915                1920
Ser Gly Asp Thr Pro Thr Thr Pro Lys His Pro Lys Asp Ser Arg Glu 
                 1925                1930                1935
Asn Phe Phe Pro Val Thr Val Val Pro Thr Ala Pro Asp Pro Val Pro 
             1940                1945                1950
Ala Asp Ser Val Gln Arg Pro Ser Asp Ala His Thr Lys Pro Arg Pro 
         1955                1960                1965
Ala Leu Ala Ala Ala Thr Thr Ile Ile Thr Cys Pro Pro Ser Ala Ser 
     1970                1975                1980
Ala Ser Thr Leu Asp Gln Ser Lys Asp Pro Gly Pro Pro Arg Pro His 
 1985                1990                1995                2000
Arg Pro Glu Ala Thr Pro Ser Met Ala Ser Leu Gly Pro Glu Gly Glu 
                 2005                2010                2015
Glu Leu Ala Arg Val Ala Glu Gly Thr Ser Phe Pro Pro Gln Glu Pro 
             2020                2025                2030
Arg His Ser Pro Gln Val Lys Met Ala Pro Thr Ser Ser Pro Ala Glu 
         2035                2040                2045
Pro His Cys Trp Pro Ala Glu Ala Ala Leu Gly Thr Gly Ala Glu Pro 
     2050                2055                2060
Thr Cys Ser Gln Glu Gly Lys Leu Arg Pro Glu Pro Arg Arg Asp Gly 
 2065                2070                2075                2080
Glu Ala Gln Glu Ala Ala Ser Glu Thr Gln Pro Leu Ser Ser Pro Pro 
                 2085                2090                2095
Thr Ala Ala Ser Ser Lys Ala Pro Ser Ser Gly Ser Ala Gln Pro Pro 
             2100                2105                2110
Glu Gly His Pro Gly Lys Pro Glu Pro Ser Arg Ala Lys Ser Arg Pro 
         2115                2120                2125
Leu Pro Asn Met Pro Lys Leu Val Ile Pro Ser Ala Ala Thr Lys Phe 
     2130                2135                2140
Pro Pro Glu Ile Thr Val Thr Pro Pro Thr Pro Thr Leu Leu Ser Pro 
 2145                2150                2155                2160
Lys Gly Ser Ile Ser Glu Glu Thr Lys Gln Lys Leu Lys Ser Ala Ile 
                 2165                2170                2175
Leu Ser Ala Gln Ser Ala Ala Asn Val Arg Lys Glu Ser Leu Cys Gln 
             2180                2185                2190
Pro Ala Leu Glu Val Leu Glu Thr Ser Ser Gln Glu Ser Ser Leu Glu 
         2195                2200                2205
Ser Glu Thr Asp Glu Asp Asp Asp Tyr Met Asp Ile 
     2210                2215                2220



<210> 936
<211> 1607
<212> DNA
<213> Rattus norvegicus
<308> AF062594
<400> 936

catgctgaa  tatcgcggt  taccatatg  ggatggtgg  gacaatctc  tggagcccg  60
cagatcgcg  aaattaccg  tgcctgcgc  gctccttcc  ctcagctcc  cgtccgagc  120
tcctggaac  atatttgga  ttcttaaaa  atggcagac  ttgacaaca  agaacagtc  180
gaacttgat  aagatttgg  agatgttga  gaagtagaa  aagaagaaa  gggtgaaga  240
acaaaaatc  aagcacgtc  gctaactgt  cagatgatg  aaaatcctc  gattcttgc  300
gctcttcag  aaagacttg  tggtctggt  gacacacca  caggataca  tgaaagctt  360
cctaaggta  tcaaaagac  ggtgaatgc  ctcaagaat  ttcaagtta  atgtgcaca  420
atagaagcc  aattctatg  ggaagttca  gaccttgag  gaaagtatg  tgttctcta  480
cagcctctg  ttgataagc  atttgagat  attaatgca  tttatgaac  tacagaaga  540
gaatgtgaa  ggaaaccag  tgaggaaga  gaagtttcg  aggagctga  agaaaaggc  600
aagattgaa  atgagaaaa  ggatgaaga  aaagaagac  ctaaaggaa  tcctgagtt  660
tggttgaca  tttttaaga  tgatttgct  agtgatatg  ttcaggaac  tgacgaacc  720
attctgaag  acttgaaag  tattaaagt  aagttttcg  acgctggcc  gcctatgag  780
tttatctta  aatttcact  tgaacccaa  gaatatttc  caaatgaag  gttaacaaa  840
acttacagg  tgaggtcag  accagatga  tctgatccc  tttcttttg  tggaccaga  900
attatgggt  gtacagggt  ccagataga  tggaaaaaa  gaaagaatg  tactttgaa  960
accattaag  agaagcaga  acacaaggg  cgtgggaca  ttcgtactg  gactaaaac  1020
gtttccaag  cttctttct  taacttttt  gctcctcct  aagttcctg  gaatggaga  1080
ctggatgac  atgntgagg  aatactggc  gcagacttt  aaattggtc  ctttttacg  1140
gagcgtata  tcccaagat  agtgttata  ttcactgga  aagctattg  ggacgatga  1200
gatgactat  atgaagaag  tgaagaagc  gatgaggaa  gggaagaag  aggagatga  1260
gaaaacgat  cagactatg  cccaaagaa  gatcaaaac  cagccgagt  caagcagca  1320
tgagcagtg  ctggccttg  ggacggcct  cctgtaata  cctaaacat  actcactta  1380
ttacagcct  atggttttg  attttcttg  tagaatcag  aagtttcta  gggaaagga  1440
attgatatt  tgcagacca  tttgttcta  ccagcatcc  aactctagc  ctgtagcca  1500
gttaccgag  ccagccctt  actgcatgc  caggtcgct  cagtctggt  ctcctgaga  1560
atttcatca  gtagctatt  gtacattat  aaaccactg  gaacaat  1607



<210> 937
<211> 391
<212> PRT
<213> Rattus norvegicus
<308> AF062594
<400> 937

Met Ala Asp Ile Asp Asn Lys Glu Gln Ser Glu Leu Asp Gln Asp Leu 
  1               5                  10                  15
Glu Asp Val Glu Glu Val Glu Glu Glu Glu Thr Gly Glu Glu Thr Lys 
             20                  25                  30
Ile Lys Ala Arg Gln Leu Thr Val Gln Met Met Gln Asn Pro Gln Ile 
         35                  40                  45
Leu Ala Ala Leu Gln Glu Arg Leu Asp Gly Leu Val Asp Thr Pro Thr 
     50                  55                  60
Gly Tyr Ile Glu Ser Leu Pro Lys Val Val Lys Arg Arg Val Asn Ala 
 65                  70                  75                  80
Leu Lys Asn Leu Gln Val Lys Cys Ala Gln Ile Glu Ala Lys Phe Tyr 
                 85                  90                  95
Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala Val Leu Tyr Gln Pro 
             100                105                110
Leu Phe Asp Lys Arg Phe Glu Ile Ile Asn Ala Ile Tyr Glu Pro Thr 
         115                120                125
Glu Glu Glu Cys Glu Trp Lys Pro Asp Glu Glu Asp Glu Val Ser Glu 
     130                135                140
Glu Leu Lys Glu Lys Ala Lys Ile Glu Asp Glu Lys Lys Asp Glu Glu 
 145                150                155                160
Lys Glu Asp Pro Lys Gly Ile Pro Glu Phe Trp Leu Thr Val Phe Lys 
                 165                170                175
Asn Asp Leu Leu Ser Asp Met Val Gln Glu His Asp Glu Pro Ile Leu 
             180                185                190
Lys His Leu Lys Asp Ile Lys Val Lys Phe Ser Asp Ala Gly Gln Pro 
         195                200                205
Met Ser Phe Ile Leu Glu Phe His Phe Glu Pro Asn Glu Tyr Phe Thr 
     210                215                220
Asn Glu Val Leu Thr Lys Thr Tyr Arg Met Arg Ser Glu Pro Asp Asp 
 225                230                235                240
Ser Asp Pro Phe Ser Phe Asp Gly Pro Glu Ile Met Gly Cys Thr Gly 
                 245                250                255
Cys Gln Ile Asp Trp Lys Lys Gly Lys Asn Val Thr Leu Lys Thr Ile 
             260                265                270
Lys Lys Lys Gln Lys His Lys Gly Arg Gly Thr Val Arg Thr Val Thr 
         275                280                285
Lys Thr Val Ser Lys Thr Ser Phe Phe Asn Phe Phe Ala Pro Pro Glu 
     290                295                300
Val Pro Glu Asn Gly Asp Leu Asp Asp Asp Xaa Glu Ala Ile Leu Ala 
 305                310                315                320
Ala Asp Phe Glu Ile Gly His Phe Leu Arg Glu Arg Ile Ile Pro Arg 
                 325                330                335
Ser Val Leu Tyr Phe Thr Gly Glu Ala Ile Glu Asp Asp Asp Asp Asp 
             340                345                350
Tyr Asp Glu Glu Gly Glu Glu Ala Asp Glu Glu Gly Glu Glu Glu Gly 
         355                360                365
Asp Glu Glu Asn Asp Pro Asp Tyr Asp Pro Lys Lys Asp Gln Asn Pro 
     370                375                380
Ala Glu Cys Lys Gln Gln Ter 
 385                390



<210> 938
<211> 269
<212> DNA
<213> Homo sapiens
<308> AI678881
<400> 938

tctgttggg  tttgatcct  ctttgggtc  tagtctgga  cattttcct  atctcctcc  60
tcttcccct  cctcatctg  ttcttcacc  tcttcatca  aatcatcac  ccatctctt  120
aaaataata  accaaaaat  ctcaggtgg  aaaactatg  ccttcacta  tgtgctgca  180
actacgcac  ggcaccggg  ggaaagagt  gccagccta  cccaactgc  cacctggga  240
gcccatcag  tgctctctc  aacacgtgc  269



<210> 939
<211> 1607
<212> DNA
<213> Rattus norvegicus
<308> AF062594
<400> 939

catgctgaa  tatcgcggt  taccatatg  ggatggtgg  gacaatctc  tggagcccg  60
cagatcgcg  aaattaccg  tgcctgcgc  gctccttcc  ctcagctcc  cgtccgagc  120
tcctggaac  atatttgga  ttcttaaaa  atggcagac  ttgacaaca  agaacagtc  180
gaacttgat  aagatttgg  agatgttga  gaagtagaa  aagaagaaa  gggtgaaga  240
acaaaaatc  aagcacgtc  gctaactgt  cagatgatg  aaaatcctc  gattcttgc  300
gctcttcag  aaagacttg  tggtctggt  gacacacca  caggataca  tgaaagctt  360
cctaaggta  tcaaaagac  ggtgaatgc  ctcaagaat  ttcaagtta  atgtgcaca  420
atagaagcc  aattctatg  ggaagttca  gaccttgag  gaaagtatg  tgttctcta  480
cagcctctg  ttgataagc  atttgagat  attaatgca  tttatgaac  tacagaaga  540
gaatgtgaa  ggaaaccag  tgaggaaga  gaagtttcg  aggagctga  agaaaaggc  600
aagattgaa  atgagaaaa  ggatgaaga  aaagaagac  ctaaaggaa  tcctgagtt  660
tggttgaca  tttttaaga  tgatttgct  agtgatatg  ttcaggaac  tgacgaacc  720
attctgaag  acttgaaag  tattaaagt  aagttttcg  acgctggcc  gcctatgag  780
tttatctta  aatttcact  tgaacccaa  gaatatttc  caaatgaag  gttaacaaa  840
acttacagg  tgaggtcag  accagatga  tctgatccc  tttcttttg  tggaccaga  900
attatgggt  gtacagggt  ccagataga  tggaaaaaa  gaaagaatg  tactttgaa  960
accattaag  agaagcaga  acacaaggg  cgtgggaca  ttcgtactg  gactaaaac  1020
gtttccaag  cttctttct  taacttttt  gctcctcct  aagttcctg  gaatggaga  1080
ctggatgac  atgntgagg  aatactggc  gcagacttt  aaattggtc  ctttttacg  1140
gagcgtata  tcccaagat  agtgttata  ttcactgga  aagctattg  ggacgatga  1200
gatgactat  atgaagaag  tgaagaagc  gatgaggaa  gggaagaag  aggagatga  1260
gaaaacgat  cagactatg  cccaaagaa  gatcaaaac  cagccgagt  caagcagca  1320
tgagcagtg  ctggccttg  ggacggcct  cctgtaata  cctaaacat  actcactta  1380
ttacagcct  atggttttg  attttcttg  tagaatcag  aagtttcta  gggaaagga  1440
attgatatt  tgcagacca  tttgttcta  ccagcatcc  aactctagc  ctgtagcca  1500
gttaccgag  ccagccctt  actgcatgc  caggtcgct  cagtctggt  ctcctgaga  1560
atttcatca  gtagctatt  gtacattat  aaaccactg  gaacaat  1607



<210> 940
<211> 391
<212> PRT
<213> Rattus norvegicus
<308> AF062594
<400> 940

Met Ala Asp Ile Asp Asn Lys Glu Gln Ser Glu Leu Asp Gln Asp Leu 
  1               5                  10                  15
Glu Asp Val Glu Glu Val Glu Glu Glu Glu Thr Gly Glu Glu Thr Lys 
             20                  25                  30
Ile Lys Ala Arg Gln Leu Thr Val Gln Met Met Gln Asn Pro Gln Ile 
         35                  40                  45
Leu Ala Ala Leu Gln Glu Arg Leu Asp Gly Leu Val Asp Thr Pro Thr 
     50                  55                  60
Gly Tyr Ile Glu Ser Leu Pro Lys Val Val Lys Arg Arg Val Asn Ala 
 65                  70                  75                  80
Leu Lys Asn Leu Gln Val Lys Cys Ala Gln Ile Glu Ala Lys Phe Tyr 
                 85                  90                  95
Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala Val Leu Tyr Gln Pro 
             100                105                110
Leu Phe Asp Lys Arg Phe Glu Ile Ile Asn Ala Ile Tyr Glu Pro Thr 
         115                120                125
Glu Glu Glu Cys Glu Trp Lys Pro Asp Glu Glu Asp Glu Val Ser Glu 
     130                135                140
Glu Leu Lys Glu Lys Ala Lys Ile Glu Asp Glu Lys Lys Asp Glu Glu 
 145                150                155                160
Lys Glu Asp Pro Lys Gly Ile Pro Glu Phe Trp Leu Thr Val Phe Lys 
                 165                170                175
Asn Asp Leu Leu Ser Asp Met Val Gln Glu His Asp Glu Pro Ile Leu 
             180                185                190
Lys His Leu Lys Asp Ile Lys Val Lys Phe Ser Asp Ala Gly Gln Pro 
         195                200                205
Met Ser Phe Ile Leu Glu Phe His Phe Glu Pro Asn Glu Tyr Phe Thr 
     210                215                220
Asn Glu Val Leu Thr Lys Thr Tyr Arg Met Arg Ser Glu Pro Asp Asp 
 225                230                235                240
Ser Asp Pro Phe Ser Phe Asp Gly Pro Glu Ile Met Gly Cys Thr Gly 
                 245                250                255
Cys Gln Ile Asp Trp Lys Lys Gly Lys Asn Val Thr Leu Lys Thr Ile 
             260                265                270
Lys Lys Lys Gln Lys His Lys Gly Arg Gly Thr Val Arg Thr Val Thr 
         275                280                285
Lys Thr Val Ser Lys Thr Ser Phe Phe Asn Phe Phe Ala Pro Pro Glu 
     290                295                300
Val Pro Glu Asn Gly Asp Leu Asp Asp Asp Xaa Glu Ala Ile Leu Ala 
 305                310                315                320
Ala Asp Phe Glu Ile Gly His Phe Leu Arg Glu Arg Ile Ile Pro Arg 
                 325                330                335
Ser Val Leu Tyr Phe Thr Gly Glu Ala Ile Glu Asp Asp Asp Asp Asp 
             340                345                350
Tyr Asp Glu Glu Gly Glu Glu Ala Asp Glu Glu Gly Glu Glu Glu Gly 
         355                360                365
Asp Glu Glu Asn Asp Pro Asp Tyr Asp Pro Lys Lys Asp Gln Asn Pro 
     370                375                380
Ala Glu Cys Lys Gln Gln Ter 
 385                390



<210> 941
<211> 269
<212> DNA
<213> Homo sapiens
<308> AI678881
<400> 941

tctgttggg  tttgatcct  ctttgggtc  tagtctgga  cattttcct  atctcctcc  60
tcttcccct  cctcatctg  ttcttcacc  tcttcatca  aatcatcac  ccatctctt  120
aaaataata  accaaaaat  ctcaggtgg  aaaactatg  ccttcacta  tgtgctgca  180
actacgcac  ggcaccggg  ggaaagagt  gccagccta  cccaactgc  cacctggga  240
gcccatcag  tgctctctc  aacacgtgc  269



<210> 942
<211> 1607
<212> DNA
<213> Rattus norvegicus
<308> AF062594
<400> 942

catgctgaa  tatcgcggt  taccatatg  ggatggtgg  gacaatctc  tggagcccg  60
cagatcgcg  aaattaccg  tgcctgcgc  gctccttcc  ctcagctcc  cgtccgagc  120
tcctggaac  atatttgga  ttcttaaaa  atggcagac  ttgacaaca  agaacagtc  180
gaacttgat  aagatttgg  agatgttga  gaagtagaa  aagaagaaa  gggtgaaga  240
acaaaaatc  aagcacgtc  gctaactgt  cagatgatg  aaaatcctc  gattcttgc  300
gctcttcag  aaagacttg  tggtctggt  gacacacca  caggataca  tgaaagctt  360
cctaaggta  tcaaaagac  ggtgaatgc  ctcaagaat  ttcaagtta  atgtgcaca  420
atagaagcc  aattctatg  ggaagttca  gaccttgag  gaaagtatg  tgttctcta  480
cagcctctg  ttgataagc  atttgagat  attaatgca  tttatgaac  tacagaaga  540
gaatgtgaa  ggaaaccag  tgaggaaga  gaagtttcg  aggagctga  agaaaaggc  600
aagattgaa  atgagaaaa  ggatgaaga  aaagaagac  ctaaaggaa  tcctgagtt  660
tggttgaca  tttttaaga  tgatttgct  agtgatatg  ttcaggaac  tgacgaacc  720
attctgaag  acttgaaag  tattaaagt  aagttttcg  acgctggcc  gcctatgag  780
tttatctta  aatttcact  tgaacccaa  gaatatttc  caaatgaag  gttaacaaa  840
acttacagg  tgaggtcag  accagatga  tctgatccc  tttcttttg  tggaccaga  900
attatgggt  gtacagggt  ccagataga  tggaaaaaa  gaaagaatg  tactttgaa  960
accattaag  agaagcaga  acacaaggg  cgtgggaca  ttcgtactg  gactaaaac  1020
gtttccaag  cttctttct  taacttttt  gctcctcct  aagttcctg  gaatggaga  1080
ctggatgac  atgntgagg  aatactggc  gcagacttt  aaattggtc  ctttttacg  1140
gagcgtata  tcccaagat  agtgttata  ttcactgga  aagctattg  ggacgatga  1200
gatgactat  atgaagaag  tgaagaagc  gatgaggaa  gggaagaag  aggagatga  1260
gaaaacgat  cagactatg  cccaaagaa  gatcaaaac  cagccgagt  caagcagca  1320
tgagcagtg  ctggccttg  ggacggcct  cctgtaata  cctaaacat  actcactta  1380
ttacagcct  atggttttg  attttcttg  tagaatcag  aagtttcta  gggaaagga  1440
attgatatt  tgcagacca  tttgttcta  ccagcatcc  aactctagc  ctgtagcca  1500
gttaccgag  ccagccctt  actgcatgc  caggtcgct  cagtctggt  ctcctgaga  1560
atttcatca  gtagctatt  gtacattat  aaaccactg  gaacaat  1607



<210> 943
<211> 391
<212> PRT
<213> Rattus norvegicus
<308> AF062594
<400> 943

Met Ala Asp Ile Asp Asn Lys Glu Gln Ser Glu Leu Asp Gln Asp Leu 
  1               5                  10                  15
Glu Asp Val Glu Glu Val Glu Glu Glu Glu Thr Gly Glu Glu Thr Lys 
             20                  25                  30
Ile Lys Ala Arg Gln Leu Thr Val Gln Met Met Gln Asn Pro Gln Ile 
         35                  40                  45
Leu Ala Ala Leu Gln Glu Arg Leu Asp Gly Leu Val Asp Thr Pro Thr 
     50                  55                  60
Gly Tyr Ile Glu Ser Leu Pro Lys Val Val Lys Arg Arg Val Asn Ala 
 65                  70                  75                  80
Leu Lys Asn Leu Gln Val Lys Cys Ala Gln Ile Glu Ala Lys Phe Tyr 
                 85                  90                  95
Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala Val Leu Tyr Gln Pro 
             100                105                110
Leu Phe Asp Lys Arg Phe Glu Ile Ile Asn Ala Ile Tyr Glu Pro Thr 
         115                120                125
Glu Glu Glu Cys Glu Trp Lys Pro Asp Glu Glu Asp Glu Val Ser Glu 
     130                135                140
Glu Leu Lys Glu Lys Ala Lys Ile Glu Asp Glu Lys Lys Asp Glu Glu 
 145                150                155                160
Lys Glu Asp Pro Lys Gly Ile Pro Glu Phe Trp Leu Thr Val Phe Lys 
                 165                170                175
Asn Asp Leu Leu Ser Asp Met Val Gln Glu His Asp Glu Pro Ile Leu 
             180                185                190
Lys His Leu Lys Asp Ile Lys Val Lys Phe Ser Asp Ala Gly Gln Pro 
         195                200                205
Met Ser Phe Ile Leu Glu Phe His Phe Glu Pro Asn Glu Tyr Phe Thr 
     210                215                220
Asn Glu Val Leu Thr Lys Thr Tyr Arg Met Arg Ser Glu Pro Asp Asp 
 225                230                235                240
Ser Asp Pro Phe Ser Phe Asp Gly Pro Glu Ile Met Gly Cys Thr Gly 
                 245                250                255
Cys Gln Ile Asp Trp Lys Lys Gly Lys Asn Val Thr Leu Lys Thr Ile 
             260                265                270
Lys Lys Lys Gln Lys His Lys Gly Arg Gly Thr Val Arg Thr Val Thr 
         275                280                285
Lys Thr Val Ser Lys Thr Ser Phe Phe Asn Phe Phe Ala Pro Pro Glu 
     290                295                300
Val Pro Glu Asn Gly Asp Leu Asp Asp Asp Xaa Glu Ala Ile Leu Ala 
 305                310                315                320
Ala Asp Phe Glu Ile Gly His Phe Leu Arg Glu Arg Ile Ile Pro Arg 
                 325                330                335
Ser Val Leu Tyr Phe Thr Gly Glu Ala Ile Glu Asp Asp Asp Asp Asp 
             340                345                350
Tyr Asp Glu Glu Gly Glu Glu Ala Asp Glu Glu Gly Glu Glu Glu Gly 
         355                360                365
Asp Glu Glu Asn Asp Pro Asp Tyr Asp Pro Lys Lys Asp Gln Asn Pro 
     370                375                380
Ala Glu Cys Lys Gln Gln Ter 
 385                390



<210> 944
<211> 269
<212> DNA
<213> Homo sapiens
<308> AI678881
<400> 944

tctgttggg  tttgatcct  ctttgggtc  tagtctgga  cattttcct  atctcctcc  60
tcttcccct  cctcatctg  ttcttcacc  tcttcatca  aatcatcac  ccatctctt  120
aaaataata  accaaaaat  ctcaggtgg  aaaactatg  ccttcacta  tgtgctgca  180
actacgcac  ggcaccggg  ggaaagagt  gccagccta  cccaactgc  cacctggga  240
gcccatcag  tgctctctc  aacacgtgc  269



<210> 945
<211> 1607
<212> DNA
<213> Rattus norvegicus
<308> AF062594
<400> 945

catgctgaa  tatcgcggt  taccatatg  ggatggtgg  gacaatctc  tggagcccg  60
cagatcgcg  aaattaccg  tgcctgcgc  gctccttcc  ctcagctcc  cgtccgagc  120
tcctggaac  atatttgga  ttcttaaaa  atggcagac  ttgacaaca  agaacagtc  180
gaacttgat  aagatttgg  agatgttga  gaagtagaa  aagaagaaa  gggtgaaga  240
acaaaaatc  aagcacgtc  gctaactgt  cagatgatg  aaaatcctc  gattcttgc  300
gctcttcag  aaagacttg  tggtctggt  gacacacca  caggataca  tgaaagctt  360
cctaaggta  tcaaaagac  ggtgaatgc  ctcaagaat  ttcaagtta  atgtgcaca  420
atagaagcc  aattctatg  ggaagttca  gaccttgag  gaaagtatg  tgttctcta  480
cagcctctg  ttgataagc  atttgagat  attaatgca  tttatgaac  tacagaaga  540
gaatgtgaa  ggaaaccag  tgaggaaga  gaagtttcg  aggagctga  agaaaaggc  600
aagattgaa  atgagaaaa  ggatgaaga  aaagaagac  ctaaaggaa  tcctgagtt  660
tggttgaca  tttttaaga  tgatttgct  agtgatatg  ttcaggaac  tgacgaacc  720
attctgaag  acttgaaag  tattaaagt  aagttttcg  acgctggcc  gcctatgag  780
tttatctta  aatttcact  tgaacccaa  gaatatttc  caaatgaag  gttaacaaa  840
acttacagg  tgaggtcag  accagatga  tctgatccc  tttcttttg  tggaccaga  900
attatgggt  gtacagggt  ccagataga  tggaaaaaa  gaaagaatg  tactttgaa  960
accattaag  agaagcaga  acacaaggg  cgtgggaca  ttcgtactg  gactaaaac  1020
gtttccaag  cttctttct  taacttttt  gctcctcct  aagttcctg  gaatggaga  1080
ctggatgac  atgntgagg  aatactggc  gcagacttt  aaattggtc  ctttttacg  1140
gagcgtata  tcccaagat  agtgttata  ttcactgga  aagctattg  ggacgatga  1200
gatgactat  atgaagaag  tgaagaagc  gatgaggaa  gggaagaag  aggagatga  1260
gaaaacgat  cagactatg  cccaaagaa  gatcaaaac  cagccgagt  caagcagca  1320
tgagcagtg  ctggccttg  ggacggcct  cctgtaata  cctaaacat  actcactta  1380
ttacagcct  atggttttg  attttcttg  tagaatcag  aagtttcta  gggaaagga  1440
attgatatt  tgcagacca  tttgttcta  ccagcatcc  aactctagc  ctgtagcca  1500
gttaccgag  ccagccctt  actgcatgc  caggtcgct  cagtctggt  ctcctgaga  1560
atttcatca  gtagctatt  gtacattat  aaaccactg  gaacaat  1607



<210> 946
<211> 391
<212> PRT
<213> Rattus norvegicus
<308> AF062594
<400> 946

Met Ala Asp Ile Asp Asn Lys Glu Gln Ser Glu Leu Asp Gln Asp Leu 
  1               5                  10                  15
Glu Asp Val Glu Glu Val Glu Glu Glu Glu Thr Gly Glu Glu Thr Lys 
             20                  25                  30
Ile Lys Ala Arg Gln Leu Thr Val Gln Met Met Gln Asn Pro Gln Ile 
         35                  40                  45
Leu Ala Ala Leu Gln Glu Arg Leu Asp Gly Leu Val Asp Thr Pro Thr 
     50                  55                  60
Gly Tyr Ile Glu Ser Leu Pro Lys Val Val Lys Arg Arg Val Asn Ala 
 65                  70                  75                  80
Leu Lys Asn Leu Gln Val Lys Cys Ala Gln Ile Glu Ala Lys Phe Tyr 
                 85                  90                  95
Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala Val Leu Tyr Gln Pro 
             100                105                110
Leu Phe Asp Lys Arg Phe Glu Ile Ile Asn Ala Ile Tyr Glu Pro Thr 
         115                120                125
Glu Glu Glu Cys Glu Trp Lys Pro Asp Glu Glu Asp Glu Val Ser Glu 
     130                135                140
Glu Leu Lys Glu Lys Ala Lys Ile Glu Asp Glu Lys Lys Asp Glu Glu 
 145                150                155                160
Lys Glu Asp Pro Lys Gly Ile Pro Glu Phe Trp Leu Thr Val Phe Lys 
                 165                170                175
Asn Asp Leu Leu Ser Asp Met Val Gln Glu His Asp Glu Pro Ile Leu 
             180                185                190
Lys His Leu Lys Asp Ile Lys Val Lys Phe Ser Asp Ala Gly Gln Pro 
         195                200                205
Met Ser Phe Ile Leu Glu Phe His Phe Glu Pro Asn Glu Tyr Phe Thr 
     210                215                220
Asn Glu Val Leu Thr Lys Thr Tyr Arg Met Arg Ser Glu Pro Asp Asp 
 225                230                235                240
Ser Asp Pro Phe Ser Phe Asp Gly Pro Glu Ile Met Gly Cys Thr Gly 
                 245                250                255
Cys Gln Ile Asp Trp Lys Lys Gly Lys Asn Val Thr Leu Lys Thr Ile 
             260                265                270
Lys Lys Lys Gln Lys His Lys Gly Arg Gly Thr Val Arg Thr Val Thr 
         275                280                285
Lys Thr Val Ser Lys Thr Ser Phe Phe Asn Phe Phe Ala Pro Pro Glu 
     290                295                300
Val Pro Glu Asn Gly Asp Leu Asp Asp Asp Xaa Glu Ala Ile Leu Ala 
 305                310                315                320
Ala Asp Phe Glu Ile Gly His Phe Leu Arg Glu Arg Ile Ile Pro Arg 
                 325                330                335
Ser Val Leu Tyr Phe Thr Gly Glu Ala Ile Glu Asp Asp Asp Asp Asp 
             340                345                350
Tyr Asp Glu Glu Gly Glu Glu Ala Asp Glu Glu Gly Glu Glu Glu Gly 
         355                360                365
Asp Glu Glu Asn Asp Pro Asp Tyr Asp Pro Lys Lys Asp Gln Asn Pro 
     370                375                380
Ala Glu Cys Lys Gln Gln Ter 
 385                390



<210> 947
<211> 269
<212> DNA
<213> Homo sapiens
<308> AI678881
<400> 947

tctgttggg  tttgatcct  ctttgggtc  tagtctgga  cattttcct  atctcctcc  60
tcttcccct  cctcatctg  ttcttcacc  tcttcatca  aatcatcac  ccatctctt  120
aaaataata  accaaaaat  ctcaggtgg  aaaactatg  ccttcacta  tgtgctgca  180
actacgcac  ggcaccggg  ggaaagagt  gccagccta  cccaactgc  cacctggga  240
gcccatcag  tgctctctc  aacacgtgc  269



<210> 948
<211> 1607
<212> DNA
<213> Rattus norvegicus
<308> AF062594
<400> 948

catgctgaa  tatcgcggt  taccatatg  ggatggtgg  gacaatctc  tggagcccg  60
cagatcgcg  aaattaccg  tgcctgcgc  gctccttcc  ctcagctcc  cgtccgagc  120
tcctggaac  atatttgga  ttcttaaaa  atggcagac  ttgacaaca  agaacagtc  180
gaacttgat  aagatttgg  agatgttga  gaagtagaa  aagaagaaa  gggtgaaga  240
acaaaaatc  aagcacgtc  gctaactgt  cagatgatg  aaaatcctc  gattcttgc  300
gctcttcag  aaagacttg  tggtctggt  gacacacca  caggataca  tgaaagctt  360
cctaaggta  tcaaaagac  ggtgaatgc  ctcaagaat  ttcaagtta  atgtgcaca  420
atagaagcc  aattctatg  ggaagttca  gaccttgag  gaaagtatg  tgttctcta  480
cagcctctg  ttgataagc  atttgagat  attaatgca  tttatgaac  tacagaaga  540
gaatgtgaa  ggaaaccag  tgaggaaga  gaagtttcg  aggagctga  agaaaaggc  600
aagattgaa  atgagaaaa  ggatgaaga  aaagaagac  ctaaaggaa  tcctgagtt  660
tggttgaca  tttttaaga  tgatttgct  agtgatatg  ttcaggaac  tgacgaacc  720
attctgaag  acttgaaag  tattaaagt  aagttttcg  acgctggcc  gcctatgag  780
tttatctta  aatttcact  tgaacccaa  gaatatttc  caaatgaag  gttaacaaa  840
acttacagg  tgaggtcag  accagatga  tctgatccc  tttcttttg  tggaccaga  900
attatgggt  gtacagggt  ccagataga  tggaaaaaa  gaaagaatg  tactttgaa  960
accattaag  agaagcaga  acacaaggg  cgtgggaca  ttcgtactg  gactaaaac  1020
gtttccaag  cttctttct  taacttttt  gctcctcct  aagttcctg  gaatggaga  1080
ctggatgac  atgntgagg  aatactggc  gcagacttt  aaattggtc  ctttttacg  1140
gagcgtata  tcccaagat  agtgttata  ttcactgga  aagctattg  ggacgatga  1200
gatgactat  atgaagaag  tgaagaagc  gatgaggaa  gggaagaag  aggagatga  1260
gaaaacgat  cagactatg  cccaaagaa  gatcaaaac  cagccgagt  caagcagca  1320
tgagcagtg  ctggccttg  ggacggcct  cctgtaata  cctaaacat  actcactta  1380
ttacagcct  atggttttg  attttcttg  tagaatcag  aagtttcta  gggaaagga  1440
attgatatt  tgcagacca  tttgttcta  ccagcatcc  aactctagc  ctgtagcca  1500
gttaccgag  ccagccctt  actgcatgc  caggtcgct  cagtctggt  ctcctgaga  1560
atttcatca  gtagctatt  gtacattat  aaaccactg  gaacaat  1607



<210> 949
<211> 391
<212> PRT
<213> Rattus norvegicus
<308> AF062594
<400> 949

Met Ala Asp Ile Asp Asn Lys Glu Gln Ser Glu Leu Asp Gln Asp Leu 
  1               5                  10                  15
Glu Asp Val Glu Glu Val Glu Glu Glu Glu Thr Gly Glu Glu Thr Lys 
             20                  25                  30
Ile Lys Ala Arg Gln Leu Thr Val Gln Met Met Gln Asn Pro Gln Ile 
         35                  40                  45
Leu Ala Ala Leu Gln Glu Arg Leu Asp Gly Leu Val Asp Thr Pro Thr 
     50                  55                  60
Gly Tyr Ile Glu Ser Leu Pro Lys Val Val Lys Arg Arg Val Asn Ala 
 65                  70                  75                  80
Leu Lys Asn Leu Gln Val Lys Cys Ala Gln Ile Glu Ala Lys Phe Tyr 
                 85                  90                  95
Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala Val Leu Tyr Gln Pro 
             100                105                110
Leu Phe Asp Lys Arg Phe Glu Ile Ile Asn Ala Ile Tyr Glu Pro Thr 
         115                120                125
Glu Glu Glu Cys Glu Trp Lys Pro Asp Glu Glu Asp Glu Val Ser Glu 
     130                135                140
Glu Leu Lys Glu Lys Ala Lys Ile Glu Asp Glu Lys Lys Asp Glu Glu 
 145                150                155                160
Lys Glu Asp Pro Lys Gly Ile Pro Glu Phe Trp Leu Thr Val Phe Lys 
                 165                170                175
Asn Asp Leu Leu Ser Asp Met Val Gln Glu His Asp Glu Pro Ile Leu 
             180                185                190
Lys His Leu Lys Asp Ile Lys Val Lys Phe Ser Asp Ala Gly Gln Pro 
         195                200                205
Met Ser Phe Ile Leu Glu Phe His Phe Glu Pro Asn Glu Tyr Phe Thr 
     210                215                220
Asn Glu Val Leu Thr Lys Thr Tyr Arg Met Arg Ser Glu Pro Asp Asp 
 225                230                235                240
Ser Asp Pro Phe Ser Phe Asp Gly Pro Glu Ile Met Gly Cys Thr Gly 
                 245                250                255
Cys Gln Ile Asp Trp Lys Lys Gly Lys Asn Val Thr Leu Lys Thr Ile 
             260                265                270
Lys Lys Lys Gln Lys His Lys Gly Arg Gly Thr Val Arg Thr Val Thr 
         275                280                285
Lys Thr Val Ser Lys Thr Ser Phe Phe Asn Phe Phe Ala Pro Pro Glu 
     290                295                300
Val Pro Glu Asn Gly Asp Leu Asp Asp Asp Xaa Glu Ala Ile Leu Ala 
 305                310                315                320
Ala Asp Phe Glu Ile Gly His Phe Leu Arg Glu Arg Ile Ile Pro Arg 
                 325                330                335
Ser Val Leu Tyr Phe Thr Gly Glu Ala Ile Glu Asp Asp Asp Asp Asp 
             340                345                350
Tyr Asp Glu Glu Gly Glu Glu Ala Asp Glu Glu Gly Glu Glu Glu Gly 
         355                360                365
Asp Glu Glu Asn Asp Pro Asp Tyr Asp Pro Lys Lys Asp Gln Asn Pro 
     370                375                380
Ala Glu Cys Lys Gln Gln Ter 
 385                390



<210> 950
<211> 269
<212> DNA
<213> Homo sapiens
<308> AI678881
<400> 950

tctgttggg  tttgatcct  ctttgggtc  tagtctgga  cattttcct  atctcctcc  60
tcttcccct  cctcatctg  ttcttcacc  tcttcatca  aatcatcac  ccatctctt  120
aaaataata  accaaaaat  ctcaggtgg  aaaactatg  ccttcacta  tgtgctgca  180
actacgcac  ggcaccggg  ggaaagagt  gccagccta  cccaactgc  cacctggga  240
gcccatcag  tgctctctc  aacacgtgc  269



<210> 951
<211> 1607
<212> DNA
<213> Rattus norvegicus
<308> AF062594
<400> 951

catgctgaa  tatcgcggt  taccatatg  ggatggtgg  gacaatctc  tggagcccg  60
cagatcgcg  aaattaccg  tgcctgcgc  gctccttcc  ctcagctcc  cgtccgagc  120
tcctggaac  atatttgga  ttcttaaaa  atggcagac  ttgacaaca  agaacagtc  180
gaacttgat  aagatttgg  agatgttga  gaagtagaa  aagaagaaa  gggtgaaga  240
acaaaaatc  aagcacgtc  gctaactgt  cagatgatg  aaaatcctc  gattcttgc  300
gctcttcag  aaagacttg  tggtctggt  gacacacca  caggataca  tgaaagctt  360
cctaaggta  tcaaaagac  ggtgaatgc  ctcaagaat  ttcaagtta  atgtgcaca  420
atagaagcc  aattctatg  ggaagttca  gaccttgag  gaaagtatg  tgttctcta  480
cagcctctg  ttgataagc  atttgagat  attaatgca  tttatgaac  tacagaaga  540
gaatgtgaa  ggaaaccag  tgaggaaga  gaagtttcg  aggagctga  agaaaaggc  600
aagattgaa  atgagaaaa  ggatgaaga  aaagaagac  ctaaaggaa  tcctgagtt  660
tggttgaca  tttttaaga  tgatttgct  agtgatatg  ttcaggaac  tgacgaacc  720
attctgaag  acttgaaag  tattaaagt  aagttttcg  acgctggcc  gcctatgag  780
tttatctta  aatttcact  tgaacccaa  gaatatttc  caaatgaag  gttaacaaa  840
acttacagg  tgaggtcag  accagatga  tctgatccc  tttcttttg  tggaccaga  900
attatgggt  gtacagggt  ccagataga  tggaaaaaa  gaaagaatg  tactttgaa  960
accattaag  agaagcaga  acacaaggg  cgtgggaca  ttcgtactg  gactaaaac  1020
gtttccaag  cttctttct  taacttttt  gctcctcct  aagttcctg  gaatggaga  1080
ctggatgac  atgntgagg  aatactggc  gcagacttt  aaattggtc  ctttttacg  1140
gagcgtata  tcccaagat  agtgttata  ttcactgga  aagctattg  ggacgatga  1200
gatgactat  atgaagaag  tgaagaagc  gatgaggaa  gggaagaag  aggagatga  1260
gaaaacgat  cagactatg  cccaaagaa  gatcaaaac  cagccgagt  caagcagca  1320
tgagcagtg  ctggccttg  ggacggcct  cctgtaata  cctaaacat  actcactta  1380
ttacagcct  atggttttg  attttcttg  tagaatcag  aagtttcta  gggaaagga  1440
attgatatt  tgcagacca  tttgttcta  ccagcatcc  aactctagc  ctgtagcca  1500
gttaccgag  ccagccctt  actgcatgc  caggtcgct  cagtctggt  ctcctgaga  1560
atttcatca  gtagctatt  gtacattat  aaaccactg  gaacaat  1607



<210> 952
<211> 391
<212> PRT
<213> Rattus norvegicus
<308> AF062594
<400> 952

Met Ala Asp Ile Asp Asn Lys Glu Gln Ser Glu Leu Asp Gln Asp Leu 
  1               5                  10                  15
Glu Asp Val Glu Glu Val Glu Glu Glu Glu Thr Gly Glu Glu Thr Lys 
             20                  25                  30
Ile Lys Ala Arg Gln Leu Thr Val Gln Met Met Gln Asn Pro Gln Ile 
         35                  40                  45
Leu Ala Ala Leu Gln Glu Arg Leu Asp Gly Leu Val Asp Thr Pro Thr 
     50                  55                  60
Gly Tyr Ile Glu Ser Leu Pro Lys Val Val Lys Arg Arg Val Asn Ala 
 65                  70                  75                  80
Leu Lys Asn Leu Gln Val Lys Cys Ala Gln Ile Glu Ala Lys Phe Tyr 
                 85                  90                  95
Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala Val Leu Tyr Gln Pro 
             100                105                110
Leu Phe Asp Lys Arg Phe Glu Ile Ile Asn Ala Ile Tyr Glu Pro Thr 
         115                120                125
Glu Glu Glu Cys Glu Trp Lys Pro Asp Glu Glu Asp Glu Val Ser Glu 
     130                135                140
Glu Leu Lys Glu Lys Ala Lys Ile Glu Asp Glu Lys Lys Asp Glu Glu 
 145                150                155                160
Lys Glu Asp Pro Lys Gly Ile Pro Glu Phe Trp Leu Thr Val Phe Lys 
                 165                170                175
Asn Asp Leu Leu Ser Asp Met Val Gln Glu His Asp Glu Pro Ile Leu 
             180                185                190
Lys His Leu Lys Asp Ile Lys Val Lys Phe Ser Asp Ala Gly Gln Pro 
         195                200                205
Met Ser Phe Ile Leu Glu Phe His Phe Glu Pro Asn Glu Tyr Phe Thr 
     210                215                220
Asn Glu Val Leu Thr Lys Thr Tyr Arg Met Arg Ser Glu Pro Asp Asp 
 225                230                235                240
Ser Asp Pro Phe Ser Phe Asp Gly Pro Glu Ile Met Gly Cys Thr Gly 
                 245                250                255
Cys Gln Ile Asp Trp Lys Lys Gly Lys Asn Val Thr Leu Lys Thr Ile 
             260                265                270
Lys Lys Lys Gln Lys His Lys Gly Arg Gly Thr Val Arg Thr Val Thr 
         275                280                285
Lys Thr Val Ser Lys Thr Ser Phe Phe Asn Phe Phe Ala Pro Pro Glu 
     290                295                300
Val Pro Glu Asn Gly Asp Leu Asp Asp Asp Xaa Glu Ala Ile Leu Ala 
 305                310                315                320
Ala Asp Phe Glu Ile Gly His Phe Leu Arg Glu Arg Ile Ile Pro Arg 
                 325                330                335
Ser Val Leu Tyr Phe Thr Gly Glu Ala Ile Glu Asp Asp Asp Asp Asp 
             340                345                350
Tyr Asp Glu Glu Gly Glu Glu Ala Asp Glu Glu Gly Glu Glu Glu Gly 
         355                360                365
Asp Glu Glu Asn Asp Pro Asp Tyr Asp Pro Lys Lys Asp Gln Asn Pro 
     370                375                380
Ala Glu Cys Lys Gln Gln Ter 
 385                390



<210> 953
<211> 269
<212> DNA
<213> Homo sapiens
<308> AI678881
<400> 953

tctgttggg  tttgatcct  ctttgggtc  tagtctgga  cattttcct  atctcctcc  60
tcttcccct  cctcatctg  ttcttcacc  tcttcatca  aatcatcac  ccatctctt  120
aaaataata  accaaaaat  ctcaggtgg  aaaactatg  ccttcacta  tgtgctgca  180
actacgcac  ggcaccggg  ggaaagagt  gccagccta  cccaactgc  cacctggga  240
gcccatcag  tgctctctc  aacacgtgc  269



<210> 954
<211> 2295
<212> DNA
<213> Rattus norvegicus
<308> AF062740
<400> 954

aatccgggc  gagagaagg  cgcgcacgg  gtggtgcgg  cgccacccg  ggcagacag  60
agcgggtgc  ctactgtgc  cggaatccc  gtcagaaca  ccagtctac  actgttctc  120
gatgccatg  cagcaccaa  tcaactgtt  tttcctctc  tccgtaact  tgaactgag  180
agaatctat  gcactgcat  ttactgcca  cacaaacat  tctgctgtt  accaccgta  240
attcctcag  atcgtctga  atacacacc  catccagca  atgctacct  ttgtaggcc  300
agggagaac  ggtggcagt  tactcaagg  aggagatat  cttctacgc  tcagaaatt  360
tacctcaca  ctccacaag  caacagcat  cttaaagct  atgaataca  cttcaaagt  420
ccagaattt  atggcaaaa  tgtcagttc  attcttgga  ttgacagca  tcgtctgcc  480
gcaaatgca  ccatagaag  ccggagaag  gcaacaacc  gcttgcaga  cagagggat  540
cttttgggc  tttttgatg  tcatgcagg  tgtgcttgc  cccaggcag  cagtgaaag  600
ctcttctat  atattgctg  ttccttgtt  ccccatgag  ctttgctag  gattgaaaa  660
gcagtggag  gtggtcggg  actgctacc  atccttcag  ggcacaagc  ccccaatga  720
tacttcagt  aggaggcat  caaattgta  ttcaacggc  tgaggactt  ctggcaaga  780
cttatagac  tcaatactg  agaatcagc  gatattgat  ttaaggagg  tttaattaa  840
gctttcaag  gacttgata  tgacatttc  ttggaggct  aagtcggtg  tcctaattc  900
tttctcaat  acctggtgc  tcgggtagc  ttttctggg  ctactgctt  tgtggccca  960
gtagatggt  ttgacctcc  tgtggctaa  actggcgat  gtagagcca  gctaggtgt  1020
caagaagaa  atggctcct  gtcagcagt  acgctctct  atgaccaca  tgctcagaa  1080
gaaagagaa  tacaacgtc  aaaactgga  cacccaaaa  atgaggcca  gagcgtggt  1140
aagcaggat  ggctgcttg  cttgctgat  ccctttagg  cttttgggg  tgtaaagtt  1200
aaatggagc  ttgaccttc  aaagagagt  atagagtct  gcccagacc  gttgaatga  1260
aatgaatac  ccaagttta  ccctcctaa  tatcataca  ctccttatc  cactgctga  1320
ccagaggta  cttatcacc  attaaggcc  caggataaa  tcctagtgt  agcaactga  1380
ggattgtgg  agactatgc  tagacagga  gtggttagg  ttgtgggtg  gtacttaac  1440
ggtatgcat  accaacagc  aatagcggt  ggggggtac  aggtgactc  gggacagat  1500
catggcctt  taacagaaa  gagagcaaa  atgtcatca  tctttgagg  tcagaatgc  1560
gcaacccat  tcattcgcc  tgctgtagg  aataatgaa  ttggagctg  tgatcatga  1620
cgactctct  aaatgctta  ccttcctga  gagcttgct  ggatgtata  agatgacat  1680
acaatcatt  tagttcagt  caattctca  gttgtagga  catatcaaa  ccaggaaca  1740
taagtgata  tatcctggc  gttcttcat  ttgaagggc  gatcaatgt  caaaagaaa  1800
taatacagt  aatatccca  tgggtcatt  taaacacat  atgtttagt  ctctagcta  1860
cccagtctt  atatctact  catcagatg  tagcatcat  agtgtctgt  ctgtcctgt  1920
ggacctcag  gtacctgca  ttgaggcag  ttgtttcct  acccaggtg  cttttaaca  1980
tgactcacc  actaagaat  tggataggt  gatacgatc  tgaataggt  aaaagcaag  2040
aacttctgg  agtattagt  aaggtagaa  acatcacca  gcccacctg  agactcctt  2100
catcataag  ctcctaatg  acatgagaa  agttattta  tgcattttt  agatgaaca  2160
ttcaggtat  cacatacat  tatgttagc  taaagtgca  gtccagtat  ttcagccat  2220
tatgaccat  aacaaagaa  tctggattt  taagttttt  tgattgtgt  ctaaagtat  2280
cttcctgaa  ggaaa  2295



<210> 955
<211> 538
<212> PRT
<213> Rattus norvegicus
<308> O88483
<400> 955

Met Pro Ala Pro Thr Gln Leu Phe Phe Pro Leu Val Arg Asn Cys Glu 
  1               5                  10                  15
Leu Ser Arg Ile Tyr Gly Thr Ala Cys Tyr Cys His His Lys His Leu 
             20                  25                  30
Cys Cys Ser Pro Pro Tyr Ile Pro Gln Asn Arg Leu Arg Tyr Thr Pro 
         35                  40                  45
His Pro Ala Tyr Ala Thr Phe Cys Arg Pro Arg Glu Asn Trp Trp Gln 
     50                  55                  60
Tyr Thr Gln Gly Arg Arg Tyr Ala Ser Thr Pro Gln Lys Phe Tyr Leu 
 65                  70                  75                  80
Thr Pro Pro Gln Val Asn Ser Ile Leu Lys Ala Asn Glu Tyr Ser Phe 
                 85                  90                  95
Lys Val Pro Glu Phe Asp Gly Lys Asn Val Ser Ser Ile Leu Gly Phe 
             100                105                110
Asp Ser Asn Arg Leu Pro Ala Asn Ala Pro Ile Glu Asp Arg Arg Ser 
         115                120                125
Ala Thr Thr Cys Leu Gln Thr Arg Gly Met Leu Leu Gly Val Phe Asp 
     130                135                140
Gly His Ala Gly Cys Ala Cys Ser Gln Ala Val Ser Glu Arg Leu Phe 
 145                150                155                160
Tyr Tyr Ile Ala Val Ser Leu Leu Pro His Glu Thr Leu Leu Glu Ile 
                 165                170                175
Glu Asn Ala Val Glu Ser Gly Arg Ala Leu Leu Pro Ile Leu Gln Trp 
             180                185                190
His Lys His Pro Asn Asp Tyr Phe Ser Lys Glu Ala Ser Lys Leu Tyr 
         195                200                205
Phe Asn Gly Leu Arg Thr Tyr Trp Gln Glu Leu Ile Asp Leu Asn Thr 
     210                215                220
Gly Glu Ser Ala Asp Ile Asp Val Lys Glu Ala Leu Ile Asn Ala Phe 
 225                230                235                240
Lys Arg Leu Asp Asn Asp Ile Ser Leu Glu Ala Gln Val Gly Asp Pro 
                 245                250                255
Asn Ser Phe Leu Asn Tyr Leu Val Leu Arg Val Ala Phe Ser Gly Ala 
             260                265                270
Thr Ala Cys Val Ala His Val Asp Gly Val Asp Leu His Val Ala Asn 
         275                280                285
Thr Gly Asp Ser Arg Ala Met Leu Gly Val Gln Glu Glu Asp Gly Ser 
     290                295                300
Trp Ser Ala Val Thr Leu Ser Asn Asp His Asn Ala Gln Asn Glu Arg 
 305                310                315                320
Glu Leu Gln Arg Leu Lys Leu Glu His Pro Lys Asn Glu Ala Lys Ser 
                 325                330                335
Val Val Lys Gln Asp Arg Leu Leu Gly Leu Leu Met Pro Phe Arg Ala 
             340                345                350
Phe Gly Asp Val Lys Phe Lys Trp Ser Ile Asp Leu Gln Lys Arg Val 
         355                360                365
Ile Glu Ser Gly Pro Asp Gln Leu Asn Asp Asn Glu Tyr Thr Lys Phe 
     370                375                380
Ile Pro Pro Asn Tyr His Thr Pro Pro Tyr Leu Thr Ala Glu Pro Glu 
 385                390                395                400
Val Thr Tyr His Arg Leu Arg Pro Gln Asp Lys Phe Leu Val Leu Ala 
                 405                410                415
Thr Asp Gly Leu Trp Glu Thr Met His Arg Gln Asp Val Val Arg Ile 
             420                425                430
Val Gly Glu Tyr Leu Thr Gly Met His His Gln Gln Pro Ile Ala Val 
         435                440                445
Gly Gly Tyr Lys Val Thr Leu Gly Gln Met His Gly Leu Leu Thr Glu 
     450                455                460
Arg Arg Ala Lys Met Ser Ser Val Phe Glu Asp Gln Asn Ala Ala Thr 
 465                470                475                480
His Leu Ile Arg His Ala Val Gly Asn Asn Glu Phe Gly Ala Val Asp 
                 485                490                495
His Glu Arg Leu Ser Lys Met Leu Ser Leu Pro Glu Glu Leu Ala Arg 
             500                505                510
Met Tyr Arg Asp Asp Ile Thr Ile Ile Val Val Gln Phe Asn Ser His 
         515                520                525
Val Val Gly Ala Tyr Gln Asn Gln Glu Gln 
     530                535



<210> 956
<211> 373
<212> DNA
<213> Homo sapiens
<308> AI024308
<400> 956

ttctggcac  ttgaaactg  attcattag  tttaaggat  ctattgact  gtggaggtg  60
gaggtaaaa  ttctgtggt  tggaagcat  tctccttcc  tgggtgtac  gccaccagt  120
ctcctttgg  ctgcaaaag  tagcatatg  tggatgagg  gtgtatctc  gtcgactct  180
aggaatgta  gatgaggaa  aacagagat  tttgtggtg  cagtaacat  cagtgccat  240
gatcctgct  agttcacag  tacggatga  aggaaaaaa  agttgagtt  gtgctggca  300
ggcatcaga  aacagtggc  ggctggaac  tctgactgg  attccgggc  cggcaggag  360
ccaaacgat  ctt  373



<210> 957
<211> 574
<212> PRT
<213> Homo sapiens
<308> NP_060914
<400> 957

Met Leu Ser Ala Pro Cys Cys Asp Asp Arg Arg Met Cys Val Cys Pro 
  1               5                  10                  15
Gly Pro Arg Arg Ile Gly Ile Pro Val Arg Ser Ser Ser Leu Pro Leu 
             20                  25                  30
Phe Ser Asp Ala Met Pro Ala Pro Thr Gln Leu Phe Phe Pro Leu Ile 
         35                  40                  45
Arg Asn Cys Glu Leu Ser Arg Ile Tyr Gly Thr Ala Cys Tyr Cys His 
     50                  55                  60
His Lys His Leu Cys Cys Ser Ser Ser Tyr Ile Pro Gln Ser Arg Leu 
 65                  70                  75                  80
Arg Tyr Thr Pro His Pro Ala Tyr Ala Thr Phe Cys Arg Pro Lys Glu 
                 85                  90                  95
Asn Trp Trp Gln Tyr Thr Gln Gly Arg Arg Tyr Ala Ser Thr Pro Gln 
             100                105                110
Lys Phe Tyr Leu Thr Pro Pro Gln Val Asn Ser Ile Leu Lys Ala Asn 
         115                120                125
Glu Tyr Ser Phe Lys Val Pro Glu Phe Asp Gly Lys Met Ser Val Leu 
     130                135                140
Ser Leu Asp Leu Thr Ala Ile Lys Leu Pro Ala Asn Ala Pro Ile Glu 
 145                150                155                160
Asp Arg Arg Ser Ala Ala Thr Cys Leu Gln Thr Arg Gly Met Leu Leu 
                 165                170                175
Gly Val Phe Asp Gly His Ala Gly Cys Ala Trp Ser Gln Ala Val Ser 
             180                185                190
Glu Arg Leu Phe Tyr Tyr Ile Ala Gly Ser Leu Val Pro His Glu Thr 
         195                200                205
Leu Leu Glu Ile Glu Asn Ala Val Glu Ser Gly Arg Ala Leu Leu Pro 
     210                215                220
Ile Leu Gln Trp His Lys His Pro Asn Asp Tyr Phe Ser Lys Glu Ala 
 225                230                235                240
Ser Lys Leu Tyr Phe Asn Ser Leu Arg Thr Tyr Trp Gln Glu Leu Ile 
                 245                250                255
Asp Leu Asn Thr Gly Glu Ser Thr Asp Ile Asp Val Lys Glu Ala Leu 
             260                265                270
Ile Asn Ala Phe Lys Arg Leu Asp Asn Asp Ile Ser Leu Glu Ala Gln 
         275                280                285
Val Gly Asp Pro Asn Ser Phe Leu Asn Tyr Leu Val Leu Arg Val Ala 
     290                295                300
Phe Ser Gly Ala Thr Ala Cys Val Ala His Val Asp Gly Val Asp Leu 
 305                310                315                320
His Val Ala Asn Thr Gly Asp Ser Arg Ala Met Leu Gly Val Gln Glu 
                 325                330                335
Glu Asp Gly Ser Trp Ser Ala Val Thr Leu Ser Asn Asp His Asn Ala 
             340                345                350
Gln Asn Glu Arg Glu Leu Glu Arg Leu Lys Leu Glu His Pro Lys Ser 
         355                360                365
Glu Ala Lys Ser Val Val Lys Gln Asp Arg Leu Leu Gly Leu Leu Met 
     370                375                380
Pro Phe Arg Ala Phe Gly Asp Val Lys Phe Lys Trp Ser Ile Asp Leu 
 385                390                395                400
Gln Lys Arg Val Ile Glu Ser Gly Pro Asp Gln Leu Asn Asp Asn Glu 
                 405                410                415
Tyr Thr Lys Phe Ile Pro Pro Asn Tyr His Thr Pro Pro Tyr Leu Thr 
             420                425                430
Ala Glu Pro Glu Val Thr Tyr His Arg Leu Arg Pro Gln Asp Lys Phe 
         435                440                445
Leu Val Leu Ala Thr Asp Gly Leu Trp Glu Thr Met His Arg Gln Asp 
     450                455                460
Val Val Arg Ile Val Gly Glu Tyr Leu Thr Gly Met His His Gln Gln 
 465                470                475                480
Pro Ile Ala Val Gly Gly Tyr Lys Val Thr Leu Gly Gln Met His Gly 
                 485                490                495
Leu Leu Thr Glu Arg Arg Thr Lys Met Ser Ser Val Phe Glu Asp Gln 
             500                505                510
Asn Ala Ala Thr His Leu Ile Arg His Ala Val Gly Asn Asn Glu Phe 
         515                520                525
Gly Thr Val Asp His Glu Arg Leu Ser Lys Met Leu Ser Leu Pro Glu 
     530                535                540
Glu Leu Ala Arg Met Tyr Arg Asp Asp Ile Thr Ile Ile Val Val Gln 
 545                550                555                560
Phe Asn Ser His Val Val Gly Ala Tyr Gln Asn Gln Glu Lys 
                 565                570



<210> 958
<211> 2295
<212> DNA
<213> Rattus norvegicus
<308> AF062740
<400> 958

aatccgggc  gagagaagg  cgcgcacgg  gtggtgcgg  cgccacccg  ggcagacag  60
agcgggtgc  ctactgtgc  cggaatccc  gtcagaaca  ccagtctac  actgttctc  120
gatgccatg  cagcaccaa  tcaactgtt  tttcctctc  tccgtaact  tgaactgag  180
agaatctat  gcactgcat  ttactgcca  cacaaacat  tctgctgtt  accaccgta  240
attcctcag  atcgtctga  atacacacc  catccagca  atgctacct  ttgtaggcc  300
agggagaac  ggtggcagt  tactcaagg  aggagatat  cttctacgc  tcagaaatt  360
tacctcaca  ctccacaag  caacagcat  cttaaagct  atgaataca  cttcaaagt  420
ccagaattt  atggcaaaa  tgtcagttc  attcttgga  ttgacagca  tcgtctgcc  480
gcaaatgca  ccatagaag  ccggagaag  gcaacaacc  gcttgcaga  cagagggat  540
cttttgggc  tttttgatg  tcatgcagg  tgtgcttgc  cccaggcag  cagtgaaag  600
ctcttctat  atattgctg  ttccttgtt  ccccatgag  ctttgctag  gattgaaaa  660
gcagtggag  gtggtcggg  actgctacc  atccttcag  ggcacaagc  ccccaatga  720
tacttcagt  aggaggcat  caaattgta  ttcaacggc  tgaggactt  ctggcaaga  780
cttatagac  tcaatactg  agaatcagc  gatattgat  ttaaggagg  tttaattaa  840
gctttcaag  gacttgata  tgacatttc  ttggaggct  aagtcggtg  tcctaattc  900
tttctcaat  acctggtgc  tcgggtagc  ttttctggg  ctactgctt  tgtggccca  960
gtagatggt  ttgacctcc  tgtggctaa  actggcgat  gtagagcca  gctaggtgt  1020
caagaagaa  atggctcct  gtcagcagt  acgctctct  atgaccaca  tgctcagaa  1080
gaaagagaa  tacaacgtc  aaaactgga  cacccaaaa  atgaggcca  gagcgtggt  1140
aagcaggat  ggctgcttg  cttgctgat  ccctttagg  cttttgggg  tgtaaagtt  1200
aaatggagc  ttgaccttc  aaagagagt  atagagtct  gcccagacc  gttgaatga  1260
aatgaatac  ccaagttta  ccctcctaa  tatcataca  ctccttatc  cactgctga  1320
ccagaggta  cttatcacc  attaaggcc  caggataaa  tcctagtgt  agcaactga  1380
ggattgtgg  agactatgc  tagacagga  gtggttagg  ttgtgggtg  gtacttaac  1440
ggtatgcat  accaacagc  aatagcggt  ggggggtac  aggtgactc  gggacagat  1500
catggcctt  taacagaaa  gagagcaaa  atgtcatca  tctttgagg  tcagaatgc  1560
gcaacccat  tcattcgcc  tgctgtagg  aataatgaa  ttggagctg  tgatcatga  1620
cgactctct  aaatgctta  ccttcctga  gagcttgct  ggatgtata  agatgacat  1680
acaatcatt  tagttcagt  caattctca  gttgtagga  catatcaaa  ccaggaaca  1740
taagtgata  tatcctggc  gttcttcat  ttgaagggc  gatcaatgt  caaaagaaa  1800
taatacagt  aatatccca  tgggtcatt  taaacacat  atgtttagt  ctctagcta  1860
cccagtctt  atatctact  catcagatg  tagcatcat  agtgtctgt  ctgtcctgt  1920
ggacctcag  gtacctgca  ttgaggcag  ttgtttcct  acccaggtg  cttttaaca  1980
tgactcacc  actaagaat  tggataggt  gatacgatc  tgaataggt  aaaagcaag  2040
aacttctgg  agtattagt  aaggtagaa  acatcacca  gcccacctg  agactcctt  2100
catcataag  ctcctaatg  acatgagaa  agttattta  tgcattttt  agatgaaca  2160
ttcaggtat  cacatacat  tatgttagc  taaagtgca  gtccagtat  ttcagccat  2220
tatgaccat  aacaaagaa  tctggattt  taagttttt  tgattgtgt  ctaaagtat  2280
cttcctgaa  ggaaa  2295



<210> 959
<211> 538
<212> PRT
<213> Rattus norvegicus
<308> O88483
<400> 959

Met Pro Ala Pro Thr Gln Leu Phe Phe Pro Leu Val Arg Asn Cys Glu 
  1               5                  10                  15
Leu Ser Arg Ile Tyr Gly Thr Ala Cys Tyr Cys His His Lys His Leu 
             20                  25                  30
Cys Cys Ser Pro Pro Tyr Ile Pro Gln Asn Arg Leu Arg Tyr Thr Pro 
         35                  40                  45
His Pro Ala Tyr Ala Thr Phe Cys Arg Pro Arg Glu Asn Trp Trp Gln 
     50                  55                  60
Tyr Thr Gln Gly Arg Arg Tyr Ala Ser Thr Pro Gln Lys Phe Tyr Leu 
 65                  70                  75                  80
Thr Pro Pro Gln Val Asn Ser Ile Leu Lys Ala Asn Glu Tyr Ser Phe 
                 85                  90                  95
Lys Val Pro Glu Phe Asp Gly Lys Asn Val Ser Ser Ile Leu Gly Phe 
             100                105                110
Asp Ser Asn Arg Leu Pro Ala Asn Ala Pro Ile Glu Asp Arg Arg Ser 
         115                120                125
Ala Thr Thr Cys Leu Gln Thr Arg Gly Met Leu Leu Gly Val Phe Asp 
     130                135                140
Gly His Ala Gly Cys Ala Cys Ser Gln Ala Val Ser Glu Arg Leu Phe 
 145                150                155                160
Tyr Tyr Ile Ala Val Ser Leu Leu Pro His Glu Thr Leu Leu Glu Ile 
                 165                170                175
Glu Asn Ala Val Glu Ser Gly Arg Ala Leu Leu Pro Ile Leu Gln Trp 
             180                185                190
His Lys His Pro Asn Asp Tyr Phe Ser Lys Glu Ala Ser Lys Leu Tyr 
         195                200                205
Phe Asn Gly Leu Arg Thr Tyr Trp Gln Glu Leu Ile Asp Leu Asn Thr 
     210                215                220
Gly Glu Ser Ala Asp Ile Asp Val Lys Glu Ala Leu Ile Asn Ala Phe 
 225                230                235                240
Lys Arg Leu Asp Asn Asp Ile Ser Leu Glu Ala Gln Val Gly Asp Pro 
                 245                250                255
Asn Ser Phe Leu Asn Tyr Leu Val Leu Arg Val Ala Phe Ser Gly Ala 
             260                265                270
Thr Ala Cys Val Ala His Val Asp Gly Val Asp Leu His Val Ala Asn 
         275                280                285
Thr Gly Asp Ser Arg Ala Met Leu Gly Val Gln Glu Glu Asp Gly Ser 
     290                295                300
Trp Ser Ala Val Thr Leu Ser Asn Asp His Asn Ala Gln Asn Glu Arg 
 305                310                315                320
Glu Leu Gln Arg Leu Lys Leu Glu His Pro Lys Asn Glu Ala Lys Ser 
                 325                330                335
Val Val Lys Gln Asp Arg Leu Leu Gly Leu Leu Met Pro Phe Arg Ala 
             340                345                350
Phe Gly Asp Val Lys Phe Lys Trp Ser Ile Asp Leu Gln Lys Arg Val 
         355                360                365
Ile Glu Ser Gly Pro Asp Gln Leu Asn Asp Asn Glu Tyr Thr Lys Phe 
     370                375                380
Ile Pro Pro Asn Tyr His Thr Pro Pro Tyr Leu Thr Ala Glu Pro Glu 
 385                390                395                400
Val Thr Tyr His Arg Leu Arg Pro Gln Asp Lys Phe Leu Val Leu Ala 
                 405                410                415
Thr Asp Gly Leu Trp Glu Thr Met His Arg Gln Asp Val Val Arg Ile 
             420                425                430
Val Gly Glu Tyr Leu Thr Gly Met His His Gln Gln Pro Ile Ala Val 
         435                440                445
Gly Gly Tyr Lys Val Thr Leu Gly Gln Met His Gly Leu Leu Thr Glu 
     450                455                460
Arg Arg Ala Lys Met Ser Ser Val Phe Glu Asp Gln Asn Ala Ala Thr 
 465                470                475                480
His Leu Ile Arg His Ala Val Gly Asn Asn Glu Phe Gly Ala Val Asp 
                 485                490                495
His Glu Arg Leu Ser Lys Met Leu Ser Leu Pro Glu Glu Leu Ala Arg 
             500                505                510
Met Tyr Arg Asp Asp Ile Thr Ile Ile Val Val Gln Phe Asn Ser His 
         515                520                525
Val Val Gly Ala Tyr Gln Asn Gln Glu Gln 
     530                535



<210> 960
<211> 373
<212> DNA
<213> Homo sapiens
<308> AI024308
<400> 960

ttctggcac  ttgaaactg  attcattag  tttaaggat  ctattgact  gtggaggtg  60
gaggtaaaa  ttctgtggt  tggaagcat  tctccttcc  tgggtgtac  gccaccagt  120
ctcctttgg  ctgcaaaag  tagcatatg  tggatgagg  gtgtatctc  gtcgactct  180
aggaatgta  gatgaggaa  aacagagat  tttgtggtg  cagtaacat  cagtgccat  240
gatcctgct  agttcacag  tacggatga  aggaaaaaa  agttgagtt  gtgctggca  300
ggcatcaga  aacagtggc  ggctggaac  tctgactgg  attccgggc  cggcaggag  360
ccaaacgat  ctt  373



<210> 961
<211> 574
<212> PRT
<213> Homo sapiens
<308> NP_060914
<400> 961

Met Leu Ser Ala Pro Cys Cys Asp Asp Arg Arg Met Cys Val Cys Pro 
  1               5                  10                  15
Gly Pro Arg Arg Ile Gly Ile Pro Val Arg Ser Ser Ser Leu Pro Leu 
             20                  25                  30
Phe Ser Asp Ala Met Pro Ala Pro Thr Gln Leu Phe Phe Pro Leu Ile 
         35                  40                  45
Arg Asn Cys Glu Leu Ser Arg Ile Tyr Gly Thr Ala Cys Tyr Cys His 
     50                  55                  60
His Lys His Leu Cys Cys Ser Ser Ser Tyr Ile Pro Gln Ser Arg Leu 
 65                  70                  75                  80
Arg Tyr Thr Pro His Pro Ala Tyr Ala Thr Phe Cys Arg Pro Lys Glu 
                 85                  90                  95
Asn Trp Trp Gln Tyr Thr Gln Gly Arg Arg Tyr Ala Ser Thr Pro Gln 
             100                105                110
Lys Phe Tyr Leu Thr Pro Pro Gln Val Asn Ser Ile Leu Lys Ala Asn 
         115                120                125
Glu Tyr Ser Phe Lys Val Pro Glu Phe Asp Gly Lys Met Ser Val Leu 
     130                135                140
Ser Leu Asp Leu Thr Ala Ile Lys Leu Pro Ala Asn Ala Pro Ile Glu 
 145                150                155                160
Asp Arg Arg Ser Ala Ala Thr Cys Leu Gln Thr Arg Gly Met Leu Leu 
                 165                170                175
Gly Val Phe Asp Gly His Ala Gly Cys Ala Trp Ser Gln Ala Val Ser 
             180                185                190
Glu Arg Leu Phe Tyr Tyr Ile Ala Gly Ser Leu Val Pro His Glu Thr 
         195                200                205
Leu Leu Glu Ile Glu Asn Ala Val Glu Ser Gly Arg Ala Leu Leu Pro 
     210                215                220
Ile Leu Gln Trp His Lys His Pro Asn Asp Tyr Phe Ser Lys Glu Ala 
 225                230                235                240
Ser Lys Leu Tyr Phe Asn Ser Leu Arg Thr Tyr Trp Gln Glu Leu Ile 
                 245                250                255
Asp Leu Asn Thr Gly Glu Ser Thr Asp Ile Asp Val Lys Glu Ala Leu 
             260                265                270
Ile Asn Ala Phe Lys Arg Leu Asp Asn Asp Ile Ser Leu Glu Ala Gln 
         275                280                285
Val Gly Asp Pro Asn Ser Phe Leu Asn Tyr Leu Val Leu Arg Val Ala 
     290                295                300
Phe Ser Gly Ala Thr Ala Cys Val Ala His Val Asp Gly Val Asp Leu 
 305                310                315                320
His Val Ala Asn Thr Gly Asp Ser Arg Ala Met Leu Gly Val Gln Glu 
                 325                330                335
Glu Asp Gly Ser Trp Ser Ala Val Thr Leu Ser Asn Asp His Asn Ala 
             340                345                350
Gln Asn Glu Arg Glu Leu Glu Arg Leu Lys Leu Glu His Pro Lys Ser 
         355                360                365
Glu Ala Lys Ser Val Val Lys Gln Asp Arg Leu Leu Gly Leu Leu Met 
     370                375                380
Pro Phe Arg Ala Phe Gly Asp Val Lys Phe Lys Trp Ser Ile Asp Leu 
 385                390                395                400
Gln Lys Arg Val Ile Glu Ser Gly Pro Asp Gln Leu Asn Asp Asn Glu 
                 405                410                415
Tyr Thr Lys Phe Ile Pro Pro Asn Tyr His Thr Pro Pro Tyr Leu Thr 
             420                425                430
Ala Glu Pro Glu Val Thr Tyr His Arg Leu Arg Pro Gln Asp Lys Phe 
         435                440                445
Leu Val Leu Ala Thr Asp Gly Leu Trp Glu Thr Met His Arg Gln Asp 
     450                455                460
Val Val Arg Ile Val Gly Glu Tyr Leu Thr Gly Met His His Gln Gln 
 465                470                475                480
Pro Ile Ala Val Gly Gly Tyr Lys Val Thr Leu Gly Gln Met His Gly 
                 485                490                495
Leu Leu Thr Glu Arg Arg Thr Lys Met Ser Ser Val Phe Glu Asp Gln 
             500                505                510
Asn Ala Ala Thr His Leu Ile Arg His Ala Val Gly Asn Asn Glu Phe 
         515                520                525
Gly Thr Val Asp His Glu Arg Leu Ser Lys Met Leu Ser Leu Pro Glu 
     530                535                540
Glu Leu Ala Arg Met Tyr Arg Asp Asp Ile Thr Ile Ile Val Val Gln 
 545                550                555                560
Phe Asn Ser His Val Val Gly Ala Tyr Gln Asn Gln Glu Lys 
                 565                570



<210> 962
<211> 1750
<212> DNA
<213> Rattus norvegicus
<308> AF062741
<400> 962

tggtgagga  aggacgagg  tactagaat  tcaagtact  cgtcctacc  gatcttcaa  60
tttgcaagg  atcgtattg  tgtattacg  gggggtaga  gcttgtact  cagggcagc  120
acgagtagg  atcaagtga  atggaggct  ttttctccc  catcattgg  cgtgaacga  180
agttctcca  atggtggct  tgctctgcg  aaagcttac  gacacacat  aaccgagga  240
gaggatttc  acttgcagc  cagccccga  caggtcagt  acctgctcc  agctggcga  300
tcatcccac  aggttctgg  tttcaacag  ggagttcca  attcagtgt  aaggtttga  360
agcaaccag  tggcggcca  ttccccagt  gaagaccga  aaggtgtgg  ttcctgcgt  420
cagacgagg  ggacggtgt  tggtatttt  gatgggcat  gtggccatg  gtgtgcaca  480
gcggtgagc  agaggcttt  ctattacat  gcggtgtcc  tcatgtccc  taagacctt  540
gagcagatg  aggaagcca  ggagaacat  aagcctttg  tgcccatcc  gcagtggct  600
aagcacccc  gagacagta  ttataaaga  atcacatcg  ttcatctgg  ccacctccg  660
gtctattgg  aggaactcc  tgacctaca  atggaaacg  gactaagca  tgaagaggc  720
ttgatgtac  ccttccaga  actggactc  gacatctcg  tagaaattc  ggctcctct  780
gaagatgag  taacgaaga  cttatccct  caggttgct  tttctgggg  gacagcctg  840
atggcccac  tcgacggag  tcacctgca  atagcaaat  ctggcgact  ccgagctat  900
ctgggtgtc  agggagaca  tggagcgtg  tcatgttta  ctcttacct  tgaccacaa  960
gcctggaat  aggcagagc  gtcccggct  aagagagaa  accccgagt  tgaggacag  1020
acactcatc  tagatgaca  gctgctggg  gtcctccta  cctgcaggg  cttcgggga  1080
gtccagcta  aatggagta  agagttgca  cggaacgtc  tagagaggg  atttgatac  1140
gaggccctc  acatctacc  gtttacccc  ccccactac  acactccac  ctacctgac  1200
gctaagcct  aggtcacat  ccacaggct  aggccccaa  ataagttcc  cgtgctggc  1260
tcagatggc  tctgggaca  gctggacaa  gaggatgtg  taaggctgg  ggtggggca  1320
ctgtccaag  tcggtcacc  gaagccagc  ctggatcaa  gaccagcca  cctgggcca  1380
atgcagagt  tgctgctgc  gaggaaagc  agcggactc  atgcagctg  ccagaatgc  1440
gccacacat  tgatcagac  tgccatcgg  agcaacgag  atggggaaa  ggagccaga  1500
cgtctggct  ccatgttga  gctgccaga  gatgtggcc  ggatgtacc  ggatgacat  1560
actgtcatg  tggtgtttt  taactcaga  tcaattgat  cctatttta  ggagggtta  1620
gagtctcac  ctgttgcca  ggctaactc  aatgccctt  atttagaac  tttccactc  1680
ttccttagt  agcaatcca  accttagta  agaacaggc  gacataggt  gctgagtaa  1740
tccggaattc  1750



<210> 963
<211> 530
<212> PRT
<213> Rattus norvegicus
<308> O88484
<400> 963

Met Ser Ser Thr Ala Ser Tyr Arg Ile Phe Asn Phe Ala Arg Asn Arg 
  1               5                  10                  15
Ile Ala Val Leu Arg Gly Gly Arg Arg Leu Tyr Ser Arg Ala Ala Thr 
             20                  25                  30
Ser Arg Asn Gln Val Lys Trp Arg Leu Phe Ser Pro Ala Ser Leu Ala 
         35                  40                  45
Val Asn Asp Ser Ser Pro His Gly Gly Phe Ala Leu Arg Lys Ala Tyr 
     50                  55                  60
Arg His Thr Ser Thr Glu Glu Glu Asp Phe His Leu Gln Leu Ser Pro 
 65                  70                  75                  80
Glu Gln Val Ser Asp Leu Leu Arg Ala Gly Glu Ser Ser His Lys Val 
                 85                  90                  95
Leu Asp Phe Asn Ser Gly Val Pro Asn Ser Val Leu Arg Phe Glu Ser 
             100                105                110
Asn Gln Leu Ala Ala Asn Ser Pro Val Glu Asp Arg Gln Gly Val Ala 
         115                120                125
Ser Cys Val Gln Thr Arg Gly Thr Val Phe Gly Ile Phe Asp Gly His 
     130                135                140
Gly Gly His Ala Cys Ala Gln Ala Val Ser Glu Arg Leu Phe Tyr Tyr 
 145                150                155                160
Met Ala Val Ser Leu Met Ser His Lys Thr Leu Glu Gln Met Glu Glu 
                 165                170                175
Ala Met Glu Asn Met Lys Pro Leu Leu Pro Ile Leu Gln Trp Leu Lys 
             180                185                190
His Pro Gly Asp Ser Ile Tyr Lys Asp Ile Thr Ser Val His Leu Asp 
         195                200                205
His Leu Arg Val Tyr Trp Gln Glu Leu Leu Asp Leu His Met Glu Thr 
     210                215                220
Gly Leu Ser Thr Glu Glu Ala Leu Met Tyr Ser Phe Gln Arg Leu Asp 
 225                230                235                240
Ser Asp Ile Ser Leu Glu Ile Gln Ala Pro Leu Glu Asp Glu Val Thr 
                 245                250                255
Lys Asn Leu Ser Leu Gln Val Ala Phe Ser Gly Ala Thr Ala Cys Met 
             260                265                270
Ala His Val Asp Gly Val His Leu His Ile Ala Asn Ala Gly Asp Cys 
         275                280                285
Arg Ala Ile Leu Gly Val Gln Gly Asp Asn Gly Ala Trp Ser Cys Leu 
     290                295                300
Pro Leu Thr Cys Asp His Asn Ala Trp Asn Glu Ala Glu Leu Ser Arg 
 305                310                315                320
Leu Lys Arg Glu His Pro Glu Ser Glu Asp Arg Thr Leu Ile Ile Asp 
                 325                330                335
Asp Arg Leu Leu Gly Val Leu Leu Pro Cys Arg Ala Phe Gly Asp Val 
             340                345                350
Gln Leu Lys Trp Ser Lys Glu Leu Gln Arg Asn Val Leu Glu Arg Gly 
         355                360                365
Phe Asp Thr Glu Ala Leu Asn Ile Tyr Gln Phe Thr Pro Pro His Tyr 
     370                375                380
His Thr Pro Pro Tyr Leu Thr Ala Lys Pro Glu Val Thr Tyr His Arg 
 385                390                395                400
Leu Arg Pro Gln Asp Lys Phe Leu Val Leu Ala Ser Asp Gly Leu Trp 
                 405                410                415
Asp Met Leu Asp Asn Glu Asp Val Val Arg Leu Val Val Gly His Leu 
             420                425                430
Ser Lys Val Gly His Gln Lys Pro Ala Leu Asp Gln Arg Pro Ala Asn 
         435                440                445
Leu Gly His Met Gln Ser Leu Leu Leu Gln Arg Lys Ala Ser Gly Leu 
     450                455                460
His Ala Ala Asp Gln Asn Ala Ala Thr His Leu Ile Arg His Ala Ile 
 465                470                475                480
Gly Ser Asn Glu Tyr Gly Glu Met Glu Pro Glu Arg Leu Ala Ala Met 
                 485                490                495
Leu Thr Leu Pro Glu Asp Val Ala Arg Met Tyr Arg Asp Asp Ile Thr 
             500                505                510
Val Met Val Val Phe Phe Asn Ser Glu Ser Ile Asp Thr Tyr Phe Lys 
         515                520                525
Glu Gly 
     530



<210> 964
<211> 3830
<212> DNA
<213> Homo sapiens
<308> AB037769
<400> 964

gactaggga  cgcctgggt  aggtgagga  ctggtggcc  cagttgtgg  actgtgcgc  60
ggcgctgaa  tgaccggac  gagcgggcg  ctgtggcct  gccagctgg  ttaaaaata  120
ccttttttg  tgaaggaac  catttgctg  tatagtttc  gaatgtcaa  tactgtgtc  180
tactggatc  taaattcta  aaggaacag  attgccaca  tgcaagggg  tagacgctt  240
tactccagg  atgtctcaa  taggaataa  ttaaaatgg  ggctctttt  ccgggtgcc  300
cccacccta  acagttccc  atgtggtgg  tttactctg  gcaaagcct  cagacacac  360
tcaacagag  aagatgatt  tcacttgca  ctcagccct  agcagataa  tgaagtgct  420
cgagctggc  agacaaccc  caagattct  gaccttgaa  gcagagtcc  aaattcagt  480
ttgcggttt  agagcaacc  gctggctgc  aattcccca  tggaggacc  gcgaggtgt  540
gcctcctgc  tgcaaacca  tggactgat  tttggcatc  tcgatggac  tggtggtca  600
gcatgtgcc  aagcagtga  cgagaggct  ttctactat  tggcagtgt  cctgatgtc  660
caccagacc  tggagcaca  ggagggagc  atggaaagc  tgaaaccct  gctgcccat  720
ctgcattgg  tcaagcacc  aggggacag  atctacaag  atgtcacat  tgtgcatct  780
gaccacctc  gtgtctatt  gcaggaact  cttgatttg  acatggaaa  gggactaag  840
attgaagaa  cattaatgt  ctccttcca  agactggat  ctgacatct  gctggaaat  900
caggccccc  tggaagatg  ggtgacaag  aacctgtca  tccaggttg  tttctctgg  960
gcaacagct  gcatggccc  tgttgatgg  attcacttg  acgtggcaa  tgctggtga  1020
tgccgagcc  tccttggtg  ccaagagga  aatggcatg  ggtcttgtc  gccccttac  1080
cgtgaccac  atgcctgga  ccaggccga  ctgtcccgg  taaagaggg  gcaccctga  1140
tcagaggac  ggacgatca  catggagga  aggctactg  gcgtcctca  cccctgcag  1200
gcctttggg  atgttcagc  gaagtggag  aaagagttg  agcgcagca  tctggagag  1260
ggcttcaat  ccgaggccc  caacattta  cagttcaca  ccccacact  ctacactcc  1320
ccctacctg  ctgctgagc  tgaggtcac  taccacagg  tgaggcccc  ggataagtt  1380
cttgtgctg  cctcagatg  cctgtggga  atgctgagc  atgaggacg  ggtaaggct  1440
gtggtgggg  acctggctg  ggcagattg  cacaagaca  acctggccc  gagacccgc  1500
aacttgggg  tcatgcaga  cctgctgct  cagaggaaa  ccagcgggc  ccacgaggc  1560
gaccaaaat  cagccacgc  gctgatcag  catgccatc  ggaacaatg  gtatgggga  1620
atggaggca  agcggctgg  ggcgatgct  acattgcca  aggacttgg  gaggatgta  1680
agggatgat  tcactgtca  tgtggtgta  tttaactca  aatcaatcg  tgcatatta  1740
aaggggggt  aagaatctc  catcctatt  tcaaggtta  cataaatgc  cttctaaaa  1800
gtttcactt  ctcctaaac  agctatcca  accttacta  taaaagcgc  ggcagattt  1860
atttgctaa  tagactaac  ggaggaaaa  aacaaacag  ctagcttta  aaaacagtg  1920
aatagcagt  atttcatgt  cctgtatgt  ctgattaag  cttatatgc  gagaggaca  1980
agcataaag  ctatagaat  ggcttgggc  tgtgtagcc  cagtcattt  ataaagatg  2040
tgttaaact  tgtcagcct  agccttcaa  gggtaaatt  aatcatgat  ctgagaata  2100
agaacttca  gagcttctt  ggtcttgcc  caaaaatct  caaatttga  aattctcct  2160
aattcacaa  catggactt  tagactatg  agagatatt  tatttgttt  tcttttatt  2220
aaattacta  ggtctaggt  tacaaagca  actacagga  ccttttcta  gcaatatcc  2280
aactttttt  tttgtgatt  tgcttgtga  aaattttgt  atactacat  ctagttctg  2340
tttcgttta  tttaaaact  aatccttaa  cttgcaaac  cgcctactg  aagcatgct  2400
ggaatgact  gttttggtt  tcagctgat  ggatctatg  ctctggacc  gctgaactt  2460
ctggtgcag  tttttgtgc  ctctactga  tcccattcc  gaaactttg  gccatgcta  2520
gaggtaact  gtctatgcc  taactcctg  cctttcctg  attagtaaa  tttcctcct  2580
ggctgagcc  ttgggggtt  attcacagc  tttaagctt  ctgattata  ctctcaaac  2640
ttcttctgt  aattccaca  aatccttct  cctctgcta  gctgaaccc  tcattcacc  2700
tgcacctgc  aactgcaaa  tattgtctg  aagaatctt  cacatgttc  tgcttccta  2760
ggctgcagg  aaggagaaa  tgtgattgc  tgtggtagt  gtggtgata  acgtttaga  2820
aggacaggt  aatttagcg  attgtggac  taagattca  cctctatct  gagaggtga  2880
aacacaaag  cttaaggac  acagtttct  accaagttt  tctgaatcc  ttcctgaga  2940
gtggtgggc  ggagggagg  gtgagactt  tcagatggg  cgcttgccc  aagactgtg  3000
gataaacca  cattgctag  cctcaggaa  tagaccata  ttagtatag  agttggggc  3060
aaaataaaa  tgtaatttg  aatggtttc  gtgggctgt  gactctttg  atttacttg  3120
aaattcagt  atgtggatc  attttggag  tgaatttca  ctcatgagt  gctgtggca  3180
ttaaacaac  ggaaatgtg  ccctaaatg  aaacaaata  aatcccaca  aaccaacaa  3240
tttatttgc  tctactacg  caggcagaa  tcttcaatt  agttgaact  catttgttg  3300
tcccttttc  catcttacc  ctttatgcc  cctactgaa  agaaaaaca  atagctagg  3360
ttggtttcc  gttttttgt  tatgtccca  ctgacattc  gtcaaatgt  gggatactt  3420
taatttggt  gtgtttctt  gtacatttt  cagtgcaac  gtttagtca  gtgttttca  3480
ctaagaaat  atcttttga  tatttaagc  ttgatcctt  tattctgaa  ccattaata  3540
tccttcttg  ctgggtgca  tggtttacg  ctgtaatcc  agcactgtg  gaggccgag  3600
cggatggat  acctgaggt  gggaattcg  gaccagcct  accaacatg  agaaactcc  3660
tctctacta  aaatacaaa  ttagccagg  gtggtggtg  atgcctgta  tcccagcta  3720
tcgggaggc  gaggcagga  aatcacttg  acccgggag  cggaggttg  ggtgagcca  3780
gatcgcacc  ttgcactcc  gcctgggca  caagagtga  actctgtctc  3830



<210> 965
<211> 529
<212> PRT
<213> Homo sapiens
<308> Q9P2J9
<400> 965

Met Ser Ser Thr Val Ser Tyr Trp Ile Leu Asn Ser Thr Arg Asn Ser 
  1               5                  10                  15
Ile Ala Thr Leu Gln Gly Gly Arg Arg Leu Tyr Ser Arg Tyr Val Ser 
             20                  25                  30
Asn Arg Asn Lys Leu Lys Trp Arg Leu Phe Ser Arg Val Pro Pro Thr 
         35                  40                  45
Leu Asn Ser Ser Pro Cys Gly Gly Phe Thr Leu Cys Lys Ala Tyr Arg 
     50                  55                  60
His Thr Ser Thr Glu Glu Asp Asp Phe His Leu Gln Leu Ser Pro Glu 
 65                  70                  75                  80
Gln Ile Asn Glu Val Leu Arg Ala Gly Glu Thr Thr His Lys Ile Leu 
                 85                  90                  95
Asp Leu Glu Ser Arg Val Pro Asn Ser Val Leu Arg Phe Glu Ser Asn 
             100                105                110
Gln Leu Ala Ala Asn Ser Pro Val Glu Asp Arg Arg Gly Val Ala Ser 
         115                120                125
Cys Leu Gln Thr Asn Gly Leu Met Phe Gly Ile Phe Asp Gly His Gly 
     130                135                140
Gly His Ala Cys Ala Gln Ala Val Ser Glu Arg Leu Phe Tyr Tyr Val 
 145                150                155                160
Ala Val Ser Leu Met Ser His Gln Thr Leu Glu His Met Glu Gly Ala 
                 165                170                175
Met Glu Ser Met Lys Pro Leu Leu Pro Ile Leu His Trp Leu Lys His 
             180                185                190
Pro Gly Asp Ser Ile Tyr Lys Asp Val Thr Ser Val His Leu Asp His 
         195                200                205
Leu Arg Val Tyr Trp Gln Glu Leu Leu Asp Leu His Met Glu Met Gly 
     210                215                220
Leu Ser Ile Glu Glu Ala Leu Met Tyr Ser Phe Gln Arg Leu Asp Ser 
 225                230                235                240
Asp Ile Ser Leu Glu Ile Gln Ala Pro Leu Glu Asp Glu Val Thr Arg 
                 245                250                255
Asn Leu Ser Leu Gln Val Ala Phe Ser Gly Ala Thr Ala Cys Met Ala 
             260                265                270
His Val Asp Gly Ile His Leu His Val Ala Asn Ala Gly Asp Cys Arg 
         275                280                285
Ala Ile Leu Gly Val Gln Glu Asp Asn Gly Met Trp Ser Cys Leu Pro 
     290                295                300
Leu Thr Arg Asp His Asn Ala Trp Asn Gln Ala Glu Leu Ser Arg Leu 
 305                310                315                320
Lys Arg Glu His Pro Glu Ser Glu Asp Arg Thr Ile Ile Met Glu Asp 
                 325                330                335
Arg Leu Leu Gly Val Leu Ile Pro Cys Arg Ala Phe Gly Asp Val Gln 
             340                345                350
Leu Lys Trp Ser Lys Glu Leu Gln Arg Ser Ile Leu Glu Arg Gly Phe 
         355                360                365
Asn Thr Glu Ala Leu Asn Ile Tyr Gln Phe Thr Pro Pro His Tyr Tyr 
     370                375                380
Thr Pro Pro Tyr Leu Thr Ala Glu Pro Glu Val Thr Tyr His Arg Leu 
 385                390                395                400
Arg Pro Gln Asp Lys Phe Leu Val Leu Ala Ser Asp Gly Leu Trp Asp 
                 405                410                415
Met Leu Ser Asn Glu Asp Val Val Arg Leu Val Val Gly His Leu Ala 
             420                425                430
Glu Ala Asp Trp His Lys Thr Asp Leu Ala Gln Arg Pro Ala Asn Leu 
         435                440                445
Gly Leu Met Gln Ser Leu Leu Leu Gln Arg Lys Ala Ser Gly Leu His 
     450                455                460
Glu Ala Asp Gln Asn Ala Ala Thr Arg Leu Ile Arg His Ala Ile Gly 
 465                470                475                480
Asn Asn Glu Tyr Gly Glu Met Glu Ala Glu Arg Leu Ala Ala Met Leu 
                 485                490                495
Thr Leu Pro Glu Asp Leu Ala Arg Met Tyr Arg Asp Asp Ile Thr Val 
             500                505                510
Thr Val Val Tyr Phe Asn Ser Glu Ser Ile Gly Ala Tyr Tyr Lys Gly 
         515                520                525
Gly 
     530



<210> 966
<211> 5602
<212> DNA
<213> Rattus norvegicus
<308> AF063102
<400> 966

gaaaatatt  aaagggatc  ataatggtg  cttctggtt  cagaatgcg  agtctctgg  60
ttatcatga  aatcagttt  tcaccgaat  ccgaaggtt  cagcagagc  gccttgcca  120
tcgggttag  tagacgaga  ctgtcctgt  aaggttatt  tatagacct  cgatgtccg  180
gcagtgacg  catcatgat  gagagcgca  actacggtc  gacggacga  aagatctgc  240
acgcagacc  ctttcagat  gagaacaca  actgctacc  ccctgatgc  ttcaaaatc  300
tgactcaaa  gtgcaacaa  cgaacacag  gtgtagtag  taccgggtc  gatgtattt  360
ctgatccat  tcccggaac  tacaaatac  ttgaagttc  atatgaatg  gtcccttac  420
tggagcaaa  agtytttgt  tgtcctgga  ccttgaaag  aattgtgga  tctccaagt  480
tctatgaag  tgagcaaaa  gcaggtgct  ggtgcaagg  cccccttca  gctgcagat  540
aaatttatt  tatgccctg  actccctac  gcaccgata  cttaataga  tatgcttct  600
tagaagatt  tcaaaacag  cgccagaca  caacataca  acttccaaa  cgagtggac  660
gtactggat  tgtggtgta  gacggggca  tcttcttca  caaagaaag  acgagaaac  720
ttgttaaat  tgacttgag  actagaatc  agagtgggg  ggccataat  aactacgcc  780
actaccatg  cacctcacc  tacagatgg  gggggaaga  tgacattga  ctggcagtg  840
atgaaaatg  cttgtgggt  atctacgcc  ccgagcaga  caacggaat  atcgtgatt  900
gccagctca  tccgtacac  ctccgattc  aagcaacct  ggagacgac  tatgacaag  960
gtgcggcgt  caatgcttt  atgatatgc  gggtcctct  cgtggtcag  tcagtgtac  1020
aagacaatg  aagcgaagc  ggcaagaac  tcatcgact  catttacaa  acaaggttg  1080
gccggggag  gcacgtgga  gttcccttc  ccaaccagt  ccagtacat  gctgcagtg  1140
attacaacc  aagagacaa  caactctac  tatggaaca  taactttat  ttacggtat  1200
ctctggagt  tggtccacc  gaccctgcc  aagtgccta  cacagctgt  acaataact  1260
cttcagctg  gctgttcaa  accacagtg  caaccacaa  cagtacttc  cagagaggc  1320
ccgtgagca  cacagtcgc  ggtcctcag  aaggaagcc  agggacaaa  ccacctcca  1380
cagtctcta  aaccaaaat  cctcctgta  caaatattt  tcccctgcc  gagagattc  1440
gcgaagcgt  agaaatgaa  gggataaag  ggcctcaga  acaaagggg  atgatggtt  1500
agcgaccgt  tcccaaggg  acaagagga  cggcctcgt  tctctgcat  gcttccaca  1560
gaacctgga  cccgaaggg  ccggatctt  gcaactgca  ctctcactg  gtgaatcag  1620
tggcccaga  gatcagaag  ggagagaat  ctgcaagtc  ggccaacga  ctggctaag  1680
acaccaagg  gacggtgtt  gctggggat  tgagctcct  tgtgaggct  atggaacag  1740
tggtggaca  cctggatgc  cagctgcag  agctgaaac  gagcgagaa  gactcggcc  1800
ggaggagtt  taacaagct  caaaaacga  agaagacat  cagggctta  cttaaggcc  1860
ttgtggaca  agtagataa  cttctgaga  ccgagactt  ggactgctg  aaacacatg  1920
attcctcag  gcaggcgca  acagccacc  tgctgttgg  caccttgga  gaaggagca  1980
ttgtcctgg  agacaacct  ttggaacca  cccgggtct  aatgccaac  gataatatt  2040
ttctagaag  cgctgtcct  agcacggaa  gacaggtcc  agacttcac  ttccatctc  2100
gcttcaagg  ggccttcag  tccatccag  tctcagcca  caccgtcaa  caaaacagc  2160
gaaacgggc  ggcaaaggt  gtattcatc  tttaccgga  tctgggacc  ttcctgagc  2220
ccgaaaatg  gaccgtcaa  ctgggcgca  acctcctgg  tcggaacag  accatcgca  2280
tgaactcgc  cgtcctttc  gtctccatc  ataaggagt  cagccgtgt  tacttgaca  2340
acccggtgc  tttttcaat  ccacacatt  attctgaca  ttatttcaa  gcaaactgc  2400
ccttctgga  ctactcaga  agaaccatg  tgggatatt  gtctaccca  ggctgcaag  2460
tggttgaca  taataaaac  cgcacgacg  gtgcatgca  ccacctaac  aattttgct  2520
ttctcatgg  ccacaggga  attgtgtac  aagatggcg  ccacaaatt  ctgctgaca  2580
tcatcacct  ggtgggcat  gttgtctcc  tcgtctgcc  ggctatctg  atcttcacc  2640
tctgcttct  ccgaggcct  caaagcgac  gcaacacga  ccacaagaa  ctgtgtatc  2700
acctcttca  cgctgagtt  attttccta  taggcattg  taaaacaca  tacacgatt  2760
cgtgccccg  gtttgcagg  ctcctgcac  ttttcttcc  ggctgcttt  tcctggatg  2820
gcctagaag  tgtgcagct  tacctcatg  tggttgaag  tttcgagag  gaatactca  2880
ggaagaagt  ttactatgt  gccgggtac  tcttccctg  cacagtggt  ggtgtttca  2940
ctgctatcg  ctccaagag  tacgggaca  tagaggctt  ctggcttca  gttgataac  3000
atttcatat  gagtttcat  gggcctgtt  ctttcatca  tctgctaaa  attattttc  3060
tggtgatca  gctgtgcaa  atggtgaaa  attcaaaca  tttgaaacc  gattctagc  3120
ggttggaaa  cattaataa  taccgtgtt  gtgatggat  ctataatac  gacttacct  3180
gctatgaag  taataagcc  tttatcaag  cttgggtgc  cggtgcgtt  gccctgctg  3240
gtctcctgg  cctaacctg  tcctttggg  tgctttttg  taacgagga  accgttgtc  3300
tggcttatc  cttcaccgc  tttaatgct  tccagggac  gtttatttt  atcttccac  3360
gtgctcttc  aaagaaagt  cggaaagag  atgccaagt  cttcagaca  tggtactgc  3420
gtggcggcc  cccgaccga  agcccgcac  gctctgtaa  ggcgtccac  tcccgcacc  3480
gtgctcgct  ctcctctgg  acacagagc  gtataagaa  gatgtggaa  gacaccgtg  3540
ggaagcagt  tgaatcgtc  tttatctca  gtgacatca  tagcacttc  acccttaat  3600
aaggaatga  tggcaatta  ctactaaca  accctcttc  tcgacccca  ggcactaac  3660
acccctata  cacattgct  gctgaaaca  ttgtatgta  tgccccttc  gcgcccgtg  3720
ttaactcac  aggacattc  ctgaacaat  cccgggaca  cagcgccat  gatactcta  3780
cgctaaatg  taacttcaa  aacagctac  ccctgcgca  ggccgacta  cacgacggc  3840
tgcaggttg  ggactgtgg  ctaagtctg  acgacaccg  gtttgagaa  atgatcatt  3900
cagagttag  gcacaacaa  ctccggggt  gcaacaaaa  ccacaactt  gagctcaag  3960
tcccagtta  acccgtgat  ggcggcagc  gcagcgaag  tgacgcgat  gtggccgac  4020
cctcatctt  gatgcacgg  gataaccca  ggctggaat  ccgccacaa  gagctggag  4080
caccgctca  ccctcagcg  actcactcg  ttctgtacc  accccagaa  aaagtgaaa  4140
ccgaggcaa  cgacagcta  gtctcccag  tgacggccg  ggccgacga  cacctccag  4200
cccccaaca  agactctct  tacacgagc  tgcccaacc  aagagactc  ccctacccg  4260
agagcagcc  ggacatggc  gaggacctg  ctccctcca  gaggagcga  aacgaggac  4320
tttactaca  aagtatgcc  aatcttggg  ctggccgcc  gctccagat  tgctaccag  4380
tcagcagag  caatagcga  ggctacatc  tccccatta  caaagaagg  tgcatccca  4440
agggggacg  cagggaagg  cagatgcag  tggtaacaa  tctttaata  tacagctaa  4500
gaattccta  ggccacatg  aagtattaa  tgctaaaga  tgtgccagc  ggccctgca  4560
ctctcccca  ctcggccag  agaaccggc  ctgctggcc  gcggttctc  actgtagga  4620
aaaaaaatg  actgaacct  gcggttctg  gaattttta  aaaacatgc  aaaactttg  4680
atatacaca  agtatacta  attgaatta  ttgttacaa  gaaaaaaga  atgccaacc  4740
ggtatttta  gtttctgct  ctgtgtaga  agattgtaa  acaaacagg  gaccctccc  4800
gccatgatc  cgcggcagt  ggtgaactg  gtctgtaaa  agaacccta  cgttttggg  4860
tttttttgt  tgtttgttt  tttttgttt  tgttttgta  gcctgcatt  tattatata  4920
aagacgtag  ctttaagat  ctgtgggac  aattgactg  atcttactt  tcctgacaa  4980
acttggaaa  gcaggagag  gattctgca  ccgtttgca  ttccctgca  accttttac  5040
ttaaggcag  caccgaaac  atgtttaac  agtagcaat  aagccacag  ccttatctc  5100
tgtttcctc  actgtacaa  gaactgttc  catgaagaa  aaaaaagtt  atggctaaa  5160
aaaattata  tttgttcta  tgctagggt  aaaataaat  catttgtgt  caactgaga  5220
atcattaaa  taattttaa  aagagtttg  agaaaatat  gtgtcaagc  cttggttgc  5280
caaaatagg  gatgtctct  ctcccaccc  ccatggtga  tttgtgccc  tctttgttg  5340
ttcccactg  agacggtgt  tgctctgac  gcttagccc  ctttcttac  cttaaattt  5400
ttattgcca  aagagtgtg  tttatgggg  gaaaactct  tgaagtcct  ccatgcctt  5460
cacaaatgt  gggaaatct  gaggtcttg  gtcaaccct  tgtttattc  ggaacagag  5520
gcgaagggg  cactgggca  ttctcacaa  ctttctagt  aacaaaagg  gcctattct  5580
ttataaaaa  aaaaaaaaa  aa  5602



<210> 967
<211> 1488
<212> PRT
<213> Rattus norvegicus
<308> AF063102
<400> 967

Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Met Ile 
  1               5                  10                  15
Ile Ser Phe Ser Pro Asn Thr Glu Gly Phe Ser Arg Ala Ala Leu Pro 
             20                  25                  30
Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp 
         35                  40                  45
Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr 
     50                  55                  60
Gly Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu 
 65                  70                  75                  80
Asn Thr Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Thr Gln Arg 
                 85                  90                  95
Cys Asn Asn Arg Thr Gln Cys Val Val Val Thr Gly Ser Asp Val Phe 
             100                105                110
Pro Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu 
         115                120                125
Cys Val Pro Tyr Met Glu Gln Lys Val Phe Val Cys Pro Gly Thr Leu 
     130                135                140
Lys Ala Ile Val Asp Ser Pro Ser Ile Tyr Glu Ala Glu Gln Lys Ala 
 145                150                155                160
Gly Ala Trp Cys Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe 
                 165                170                175
Met Pro Trp Thr Pro Tyr Arg Thr Asp Thr Leu Ile Glu Tyr Ala Ser 
             180                185                190
Leu Glu Asp Phe Gln Asn Ser Arg Gln Thr Thr Thr Tyr Lys Leu Pro 
         195                200                205
Asn Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe 
     210                215                220
Phe Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr 
 225                230                235                240
Arg Ile Lys Ser Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp 
                 245                250                255
Thr Ser Pro Tyr Arg Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val 
             260                265                270
Asp Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly 
         275                280                285
Met Ile Val Ile Ser Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Ala 
     290                295                300
Thr Trp Glu Thr Thr Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met 
 305                310                315                320
Ile Cys Gly Val Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu 
                 325                330                335
Ser Glu Ala Gly Lys Asn Val Ile Asp Tyr Ile Tyr Asn Thr Arg Leu 
             340                345                350
Ser Arg Gly Glu His Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr 
         355                360                365
Ile Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp 
     370                375                380
Asn Asn Asn Phe Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp 
 385                390                395                400
Pro Ala Gln Val Pro Thr Thr Ala Val Thr Ile Thr Ser Ser Ala Glu 
                 405                410                415
Leu Phe Lys Thr Thr Val Ser Thr Thr Ser Ser Thr Ser Gln Arg Gly 
             420                425                430
Pro Val Ser Ser Thr Val Ala Gly Pro Gln Glu Gly Ser Arg Gly Thr 
         435                440                445
Lys Pro Pro Pro Ala Val Ser Thr Thr Lys Ile Pro Pro Val Thr Asn 
     450                455                460
Ile Phe Pro Leu Pro Glu Arg Phe Cys Glu Ala Leu Glu Met Lys Gly 
 465                470                475                480
Ile Lys Trp Pro Gln Thr Gln Arg Gly Met Met Val Glu Arg Pro Cys 
                 485                490                495
Pro Lys Gly Thr Arg Gly Thr Ala Ser Tyr Leu Cys Met Ala Ser Thr 
             500                505                510
Gly Thr Trp Asn Pro Lys Gly Pro Asp Leu Ser Asn Cys Thr Ser His 
         515                520                525
Trp Val Asn Gln Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala 
     530                535                540
Ser Leu Ala Asn Glu Leu Ala Lys His Thr Lys Gly Thr Val Phe Ala 
 545                550                555                560
Gly Asp Val Ser Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile 
                 565                570                575
Leu Asp Ala Gln Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala 
             580                585                590
Gly Arg Ser Tyr Asn Lys Leu Gln Lys Arg Glu Lys Thr Cys Arg Ala 
         595                600                605
Tyr Leu Lys Ala Ile Val Asp Thr Val Asp Asn Leu Leu Arg Ala Glu 
     610                615                620
Thr Leu Asp Cys Trp Lys His Met Asn Ser Ser Glu Gln Ala His Thr 
 625                630                635                640
Ala Thr Met Leu Leu Asp Thr Leu Glu Glu Gly Ala Phe Val Leu Ala 
                 645                650                655
Asp Asn Leu Leu Glu Pro Thr Arg Val Ser Met Pro Thr Asp Asn Ile 
             660                665                670
Val Leu Glu Val Ala Val Leu Ser Thr Glu Gly Gln Val Gln Asp Phe 
         675                680                685
Thr Phe His Leu Gly Phe Lys Gly Ala Phe Ser Ser Ile Gln Leu Ser 
     690                695                700
Ala Asn Thr Val Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Val Val 
 705                710                715                720
Phe Ile Ile Tyr Arg Ser Leu Gly Pro Phe Leu Ser Thr Glu Asn Ala 
                 725                730                735
Thr Val Lys Leu Gly Ala Asp Leu Leu Gly Arg Asn Ser Thr Ile Ala 
             740                745                750
Val Asn Ser His Val Leu Ser Val Ser Ile Asn Lys Glu Ser Ser Arg 
         755                760                765
Val Tyr Leu Thr Asp Pro Val Leu Phe Ser Met Pro His Ile Asp Ser 
     770                775                780
Asp Asn Tyr Phe Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg 
 785                790                795                800
Thr Met Met Gly Tyr Trp Ser Thr Gln Gly Cys Lys Leu Val Asp Thr 
                 805                810                815
Asn Lys Thr Arg Thr Thr Cys Ala Cys Ser His Leu Thr Asn Phe Ala 
             820                825                830
Ile Leu Met Ala His Arg Glu Ile Val Tyr Lys Asp Gly Val His Lys 
         835                840                845
Leu Leu Leu Thr Val Ile Thr Trp Val Gly Ile Val Val Ser Leu Val 
     850                855                860
Cys Leu Ala Ile Cys Ile Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln 
 865                870                875                880
Ser Asp Arg Asn Thr Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile 
                 885                890                895
Ala Glu Phe Ile Phe Leu Ile Gly Ile Asp Lys Thr Gln Tyr Thr Ile 
             900                905                910
Ala Cys Pro Val Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala 
         915                920                925
Phe Ser Trp Met Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val 
     930                935                940
Glu Val Phe Glu Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala 
 945                950                955                960
Gly Tyr Leu Phe Pro Ala Thr Val Val Gly Val Ser Ala Ala Ile Asp 
                 965                970                975
Ser Lys Ser Tyr Gly Thr Leu Glu Ala Cys Trp Leu His Val Asp Asn 
             980                985                990
Tyr Phe Ile Trp Ser Phe Ile Gly Pro Val Thr Phe Ile Ile Leu Leu 
         995                1000                1005
Asn Ile Ile Phe Leu Val Ile Thr Leu Cys Lys Met Val Lys His Ser 
     1010                1015                1020
Asn Thr Leu Lys Pro Asp Ser Ser Arg Leu Glu Asn Ile Asn Asn Tyr 
 1025                1030                1035                1040
Arg Val Cys Asp Gly Tyr Tyr Asn Thr Asp Leu Pro Gly Tyr Glu Asp 
                 1045                1050                1055
Asn Lys Pro Phe Ile Lys Ser Trp Val Leu Gly Ala Phe Ala Leu Leu 
             1060                1065                1070
Cys Leu Leu Gly Leu Thr Trp Ser Phe Gly Leu Leu Phe Val Asn Glu 
         1075                1080                1085
Glu Thr Val Val Met Ala Tyr Leu Phe Thr Ala Phe Asn Ala Phe Gln 
     1090                1095                1100
Gly Leu Phe Ile Phe Ile Phe His Cys Ala Leu Gln Lys Lys Val Arg 
 1105                1110                1115                1120
Lys Glu Tyr Ala Lys Cys Phe Arg His Trp Tyr Cys Cys Gly Gly Leu 
                 1125                1130                1135
Pro Thr Glu Ser Pro His Ser Ser Val Lys Ala Ser Thr Ser Arg Thr 
             1140                1145                1150
Ser Ala Arg Tyr Ser Ser Gly Thr Gln Ser Arg Ile Arg Arg Met Trp 
         1155                1160                1165
Asn Asp Thr Val Arg Lys Gln Ser Glu Ser Ser Phe Ile Ser Gly Asp 
     1170                1175                1180
Ile Asn Ser Thr Ser Thr Leu Asn Gln Gly Met Thr Gly Asn Tyr Leu 
 1185                1190                1195                1200
Leu Thr Asn Pro Leu Leu Arg Pro His Gly Thr Asn Asn Pro Tyr Asn 
                 1205                1210                1215
Thr Leu Leu Ala Glu Thr Val Val Cys Asn Ala Pro Ser Ala Pro Val 
             1220                1225                1230
Phe Asn Ser Pro Gly His Ser Leu Asn Asn Thr Arg Asp Thr Ser Ala 
         1235                1240                1245
Met Asp Thr Leu Pro Leu Asn Gly Asn Phe Asn Asn Ser Tyr Ser Leu 
     1250                1255                1260
Arg Lys Ala Asp Tyr His Asp Gly Val Gln Val Val Asp Cys Gly Leu 
 1265                1270                1275                1280
Ser Leu Asn Asp Thr Ala Phe Glu Lys Met Ile Ile Ser Glu Leu Val 
                 1285                1290                1295
His Asn Asn Leu Arg Gly Ser Asn Lys Thr His Asn Leu Glu Leu Lys 
             1300                1305                1310
Leu Pro Val Lys Pro Val Ile Gly Gly Ser Ser Ser Glu Asp Asp Ala 
         1315                1320                1325
Ile Val Ala Asp Ala Ser Ser Leu Met His Gly Asp Asn Pro Gly Leu 
     1330                1335                1340
Glu Phe Arg His Lys Glu Leu Glu Ala Pro Leu Ile Pro Gln Arg Thr 
 1345                1350                1355                1360
His Ser Leu Leu Tyr Gln Pro Gln Lys Lys Val Lys Pro Glu Ala Thr 
                 1365                1370                1375
Asp Ser Tyr Val Ser Gln Leu Thr Ala Glu Ala Asp Glu His Leu Gln 
             1380                1385                1390
Ser Pro Asn Arg Asp Ser Leu Tyr Thr Ser Met Pro Asn Leu Arg Asp 
         1395                1400                1405
Ser Pro Tyr Pro Glu Ser Ser Pro Asp Met Ala Glu Asp Leu Ser Pro 
     1410                1415                1420
Ser Arg Arg Ser Glu Asn Glu Asp Ile Tyr Tyr Lys Ser Met Pro Asn 
 1425                1430                1435                1440
Leu Gly Ala Gly Arg Gln Leu Gln Met Cys Tyr Gln Ile Ser Arg Gly 
                 1445                1450                1455
Asn Ser Asp Gly Tyr Ile Ile Pro Ile Asn Lys Glu Gly Cys Ile Pro 
             1460                1465                1470
Glu Gly Asp Val Arg Glu Gly Gln Met Gln Leu Val Thr Ser Leu Ter 
         1475                1480                1485



<210> 968
<211> 172
<212> DNA
<213> Homo sapiens
<308> AW238191
<400> 968

gcgtcgaca  acatgcaaa  actttgtat  tacacagag  atactaaat  gaattattt  60
ttacaaaga  aaaagaaat  ccaaccagg  attttacgt  tctgctgct  tgtagagag  120
ttgtaaaac  aacaagaga  cctccctcc  gtcgacgcg  ccgcggtcg  cg  172



<210> 969
<211> 1021
<212> PRT
<213> Homo sapiens
<308> BAA34506
<400> 969

Glu Gly Ser Lys Gly Thr Lys Pro Pro Pro Ala Val Ser Thr Thr Lys 
  1               5                  10                  15
Ile Pro Pro Ile Thr Asn Ile Phe Pro Leu Pro Glu Arg Phe Cys Glu 
             20                  25                  30
Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro Gln Thr Gln Arg Gly Met 
         35                  40                  45
Met Val Glu Arg Pro Cys Pro Lys Gly Thr Arg Gly Thr Ala Ser Tyr 
     50                  55                  60
Leu Cys Met Ile Ser Thr Gly Thr Trp Asn Pro Lys Gly Pro Asp Leu 
 65                  70                  75                  80
Ser Asn Cys Thr Ser His Trp Val Asn Gln Leu Ala Gln Lys Ile Arg 
                 85                  90                  95
Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn Glu Leu Ala Lys His Thr 
             100                105                110
Lys Gly Pro Val Phe Ala Gly Asp Val Ser Ser Ser Val Arg Leu Met 
         115                120                125
Glu Gln Leu Val Asp Ile Leu Asp Ala Gln Leu Gln Glu Leu Lys Pro 
     130                135                140
Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr Asn Lys Leu Gln Lys Arg 
 145                150                155                160
Glu Lys Thr Cys Arg Ala Tyr Leu Lys Ala Ile Val Asp Thr Val Asp 
                 165                170                175
Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys His Met Asn Ser 
             180                185                190
Ser Glu Gln Ala His Thr Ala Thr Met Leu Leu Asp Thr Leu Glu Glu 
         195                200                205
Gly Ala Phe Val Leu Ala Asp Asn Leu Leu Glu Pro Thr Arg Val Ser 
     210                215                220
Met Pro Thr Glu Asn Ile Val Leu Glu Val Ala Val Leu Ser Thr Glu 
 225                230                235                240
Gly Gln Ile Gln Asp Phe Lys Phe Pro Leu Gly Ile Lys Gly Ala Gly 
                 245                250                255
Ser Ser Ile Gln Leu Ser Ala Asn Thr Val Lys Gln Asn Ser Arg Asn 
             260                265                270
Gly Leu Ala Lys Leu Val Phe Ile Ile Tyr Arg Ser Leu Gly Gln Phe 
         275                280                285
Leu Ser Thr Glu Asn Ala Thr Ile Lys Leu Gly Ala Asp Phe Ile Gly 
     290                295                300
Arg Asn Ser Thr Ile Ala Val Asn Ser His Val Ile Ser Val Ser Ile 
 305                310                315                320
Asn Lys Glu Ser Ser Arg Val Tyr Leu Thr Asp Pro Val Leu Phe Thr 
                 325                330                335
Leu Pro His Ile Asp Pro Asp Asn Tyr Phe Asn Ala Asn Cys Ser Phe 
             340                345                350
Trp Asn Tyr Ser Glu Arg Thr Met Met Gly Tyr Trp Ser Thr Gln Gly 
         355                360                365
Cys Lys Leu Val Asp Thr Asn Lys Thr Arg Thr Thr Cys Ala Cys Ser 
     370                375                380
His Leu Thr Asn Phe Ala Ile Leu Met Ala His Arg Glu Ile Ala Tyr 
 385                390                395                400
Lys Asp Gly Val His Glu Leu Leu Leu Thr Val Ile Thr Trp Val Gly 
                 405                410                415
Ile Val Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Phe Thr Phe Cys 
             420                425                430
Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Thr Ile His Lys Asn Leu 
         435                440                445
Cys Ile Asn Leu Phe Ile Ala Glu Phe Ile Phe Leu Ile Gly Ile Asp 
     450                455                460
Lys Thr Lys Tyr Ala Ile Ala Cys Pro Ile Phe Ala Gly Leu Leu His 
 465                470                475                480
Phe Phe Phe Leu Ala Ala Phe Ala Trp Met Cys Leu Glu Gly Val Gln 
                 485                490                495
Leu Tyr Leu Met Leu Val Glu Val Phe Glu Ser Glu Tyr Ser Arg Lys 
             500                505                510
Lys Tyr Tyr Tyr Val Ala Gly Tyr Leu Phe Pro Ala Thr Val Val Gly 
         515                520                525
Val Ser Ala Ala Ile Asp Tyr Lys Ser Tyr Gly Thr Glu Lys Ala Cys 
     530                535                540
Trp Leu His Val Asp Asn Tyr Phe Ile Trp Ser Phe Ile Gly Pro Val 
 545                550                555                560
Thr Phe Ile Ile Leu Leu Asn Ile Ile Phe Leu Val Ile Thr Leu Cys 
                 565                570                575
Lys Met Val Lys His Ser Asn Thr Leu Lys Pro Asp Ser Ser Arg Leu 
             580                585                590
Glu Asn Ile Lys Ser Trp Val Leu Gly Ala Phe Ala Leu Leu Cys Leu 
         595                600                605
Leu Gly Leu Thr Trp Ser Phe Gly Leu Leu Phe Ile Asn Glu Glu Thr 
     610                615                620
Ile Val Met Ala Tyr Leu Phe Thr Ile Phe Asn Ala Phe Gln Gly Val 
 625                630                635                640
Phe Ile Phe Ile Phe His Cys Ala Leu Gln Lys Lys Val Arg Lys Glu 
                 645                650                655
Tyr Gly Lys Cys Phe Arg His Ser Tyr Cys Cys Gly Gly Leu Pro Thr 
             660                665                670
Glu Ser Pro His Ser Ser Val Lys Ala Ser Thr Thr Arg Thr Ser Ala 
         675                680                685
Arg Tyr Ser Ser Gly Thr Gln Ser Arg Ile Arg Arg Met Trp Asn Asp 
     690                695                700
Thr Val Arg Lys Gln Ser Glu Ser Ser Phe Ile Ser Gly Asp Ile Asn 
 705                710                715                720
Ser Thr Ser Thr Leu Asn Gln Gly Met Thr Gly Asn Tyr Leu Leu Thr 
                 725                730                735
Asn Pro Leu Leu Arg Pro His Gly Thr Asn Asn Pro Tyr Asn Thr Leu 
             740                745                750
Leu Ala Glu Thr Val Val Cys Asn Ala Pro Ser Ala Pro Val Phe Asn 
         755                760                765
Ser Pro Gly His Ser Leu Asn Asn Ala Arg Asp Thr Ser Ala Met Asp 
     770                775                780
Thr Leu Pro Leu Asn Gly Asn Phe Asn Asn Ser Tyr Ser Leu His Lys 
 785                790                795                800
Gly Asp Tyr Asn Asp Ser Val Gln Val Val Asp Cys Gly Leu Ser Leu 
                 805                810                815
Asn Asp Thr Ala Phe Glu Lys Met Ile Ile Ser Glu Leu Val His Asn 
             820                825                830
Asn Leu Arg Gly Ser Ser Lys Thr His Asn Leu Glu Leu Thr Leu Pro 
         835                840                845
Val Lys Pro Val Ile Gly Gly Ser Ser Ser Glu Asp Asp Ala Ile Val 
     850                855                860
Ala Asp Ala Ser Ser Leu Met His Ser Asp Asn Pro Gly Leu Glu Leu 
 865                870                875                880
His His Lys Glu Leu Glu Ala Pro Leu Ile Pro Gln Arg Thr His Ser 
                 885                890                895
Leu Leu Tyr Gln Pro Gln Lys Lys Val Lys Ser Glu Gly Thr Asp Ser 
             900                905                910
Tyr Val Ser Gln Leu Thr Ala Glu Ala Glu Asp His Leu Gln Ser Pro 
         915                920                925
Asn Arg Asp Ser Leu Tyr Thr Ser Met Pro Asn Leu Arg Asp Ser Pro 
     930                935                940
Tyr Pro Glu Ser Ser Pro Asp Met Glu Glu Asp Leu Ser Pro Ser Arg 
 945                950                955                960
Arg Ser Glu Asn Glu Asp Ile Tyr Tyr Lys Ser Met Pro Asn Leu Gly 
                 965                970                975
Ala Gly His Gln Leu Gln Met Cys Tyr Gln Ile Ser Arg Gly Asn Ser 
             980                985                990
Asp Gly Tyr Ile Ile Pro Ile Asn Lys Glu Gly Cys Ile Pro Glu Gly 
         995                1000                1005
Asp Val Arg Glu Gly Gln Met Gln Leu Val Thr Ser Leu 
     1010                1015                1020



<210> 970
<211> 5602
<212> DNA
<213> Rattus norvegicus
<308> AF063102
<400> 970

gaaaatatt  aaagggatc  ataatggtg  cttctggtt  cagaatgcg  agtctctgg  60
ttatcatga  aatcagttt  tcaccgaat  ccgaaggtt  cagcagagc  gccttgcca  120
tcgggttag  tagacgaga  ctgtcctgt  aaggttatt  tatagacct  cgatgtccg  180
gcagtgacg  catcatgat  gagagcgca  actacggtc  gacggacga  aagatctgc  240
acgcagacc  ctttcagat  gagaacaca  actgctacc  ccctgatgc  ttcaaaatc  300
tgactcaaa  gtgcaacaa  cgaacacag  gtgtagtag  taccgggtc  gatgtattt  360
ctgatccat  tcccggaac  tacaaatac  ttgaagttc  atatgaatg  gtcccttac  420
tggagcaaa  agtytttgt  tgtcctgga  ccttgaaag  aattgtgga  tctccaagt  480
tctatgaag  tgagcaaaa  gcaggtgct  ggtgcaagg  cccccttca  gctgcagat  540
aaatttatt  tatgccctg  actccctac  gcaccgata  cttaataga  tatgcttct  600
tagaagatt  tcaaaacag  cgccagaca  caacataca  acttccaaa  cgagtggac  660
gtactggat  tgtggtgta  gacggggca  tcttcttca  caaagaaag  acgagaaac  720
ttgttaaat  tgacttgag  actagaatc  agagtgggg  ggccataat  aactacgcc  780
actaccatg  cacctcacc  tacagatgg  gggggaaga  tgacattga  ctggcagtg  840
atgaaaatg  cttgtgggt  atctacgcc  ccgagcaga  caacggaat  atcgtgatt  900
gccagctca  tccgtacac  ctccgattc  aagcaacct  ggagacgac  tatgacaag  960
gtgcggcgt  caatgcttt  atgatatgc  gggtcctct  cgtggtcag  tcagtgtac  1020
aagacaatg  aagcgaagc  ggcaagaac  tcatcgact  catttacaa  acaaggttg  1080
gccggggag  gcacgtgga  gttcccttc  ccaaccagt  ccagtacat  gctgcagtg  1140
attacaacc  aagagacaa  caactctac  tatggaaca  taactttat  ttacggtat  1200
ctctggagt  tggtccacc  gaccctgcc  aagtgccta  cacagctgt  acaataact  1260
cttcagctg  gctgttcaa  accacagtg  caaccacaa  cagtacttc  cagagaggc  1320
ccgtgagca  cacagtcgc  ggtcctcag  aaggaagcc  agggacaaa  ccacctcca  1380
cagtctcta  aaccaaaat  cctcctgta  caaatattt  tcccctgcc  gagagattc  1440
gcgaagcgt  agaaatgaa  gggataaag  ggcctcaga  acaaagggg  atgatggtt  1500
agcgaccgt  tcccaaggg  acaagagga  cggcctcgt  tctctgcat  gcttccaca  1560
gaacctgga  cccgaaggg  ccggatctt  gcaactgca  ctctcactg  gtgaatcag  1620
tggcccaga  gatcagaag  ggagagaat  ctgcaagtc  ggccaacga  ctggctaag  1680
acaccaagg  gacggtgtt  gctggggat  tgagctcct  tgtgaggct  atggaacag  1740
tggtggaca  cctggatgc  cagctgcag  agctgaaac  gagcgagaa  gactcggcc  1800
ggaggagtt  taacaagct  caaaaacga  agaagacat  cagggctta  cttaaggcc  1860
ttgtggaca  agtagataa  cttctgaga  ccgagactt  ggactgctg  aaacacatg  1920
attcctcag  gcaggcgca  acagccacc  tgctgttgg  caccttgga  gaaggagca  1980
ttgtcctgg  agacaacct  ttggaacca  cccgggtct  aatgccaac  gataatatt  2040
ttctagaag  cgctgtcct  agcacggaa  gacaggtcc  agacttcac  ttccatctc  2100
gcttcaagg  ggccttcag  tccatccag  tctcagcca  caccgtcaa  caaaacagc  2160
gaaacgggc  ggcaaaggt  gtattcatc  tttaccgga  tctgggacc  ttcctgagc  2220
ccgaaaatg  gaccgtcaa  ctgggcgca  acctcctgg  tcggaacag  accatcgca  2280
tgaactcgc  cgtcctttc  gtctccatc  ataaggagt  cagccgtgt  tacttgaca  2340
acccggtgc  tttttcaat  ccacacatt  attctgaca  ttatttcaa  gcaaactgc  2400
ccttctgga  ctactcaga  agaaccatg  tgggatatt  gtctaccca  ggctgcaag  2460
tggttgaca  taataaaac  cgcacgacg  gtgcatgca  ccacctaac  aattttgct  2520
ttctcatgg  ccacaggga  attgtgtac  aagatggcg  ccacaaatt  ctgctgaca  2580
tcatcacct  ggtgggcat  gttgtctcc  tcgtctgcc  ggctatctg  atcttcacc  2640
tctgcttct  ccgaggcct  caaagcgac  gcaacacga  ccacaagaa  ctgtgtatc  2700
acctcttca  cgctgagtt  attttccta  taggcattg  taaaacaca  tacacgatt  2760
cgtgccccg  gtttgcagg  ctcctgcac  ttttcttcc  ggctgcttt  tcctggatg  2820
gcctagaag  tgtgcagct  tacctcatg  tggttgaag  tttcgagag  gaatactca  2880
ggaagaagt  ttactatgt  gccgggtac  tcttccctg  cacagtggt  ggtgtttca  2940
ctgctatcg  ctccaagag  tacgggaca  tagaggctt  ctggcttca  gttgataac  3000
atttcatat  gagtttcat  gggcctgtt  ctttcatca  tctgctaaa  attattttc  3060
tggtgatca  gctgtgcaa  atggtgaaa  attcaaaca  tttgaaacc  gattctagc  3120
ggttggaaa  cattaataa  taccgtgtt  gtgatggat  ctataatac  gacttacct  3180
gctatgaag  taataagcc  tttatcaag  cttgggtgc  cggtgcgtt  gccctgctg  3240
gtctcctgg  cctaacctg  tcctttggg  tgctttttg  taacgagga  accgttgtc  3300
tggcttatc  cttcaccgc  tttaatgct  tccagggac  gtttatttt  atcttccac  3360
gtgctcttc  aaagaaagt  cggaaagag  atgccaagt  cttcagaca  tggtactgc  3420
gtggcggcc  cccgaccga  agcccgcac  gctctgtaa  ggcgtccac  tcccgcacc  3480
gtgctcgct  ctcctctgg  acacagagc  gtataagaa  gatgtggaa  gacaccgtg  3540
ggaagcagt  tgaatcgtc  tttatctca  gtgacatca  tagcacttc  acccttaat  3600
aaggaatga  tggcaatta  ctactaaca  accctcttc  tcgacccca  ggcactaac  3660
acccctata  cacattgct  gctgaaaca  ttgtatgta  tgccccttc  gcgcccgtg  3720
ttaactcac  aggacattc  ctgaacaat  cccgggaca  cagcgccat  gatactcta  3780
cgctaaatg  taacttcaa  aacagctac  ccctgcgca  ggccgacta  cacgacggc  3840
tgcaggttg  ggactgtgg  ctaagtctg  acgacaccg  gtttgagaa  atgatcatt  3900
cagagttag  gcacaacaa  ctccggggt  gcaacaaaa  ccacaactt  gagctcaag  3960
tcccagtta  acccgtgat  ggcggcagc  gcagcgaag  tgacgcgat  gtggccgac  4020
cctcatctt  gatgcacgg  gataaccca  ggctggaat  ccgccacaa  gagctggag  4080
caccgctca  ccctcagcg  actcactcg  ttctgtacc  accccagaa  aaagtgaaa  4140
ccgaggcaa  cgacagcta  gtctcccag  tgacggccg  ggccgacga  cacctccag  4200
cccccaaca  agactctct  tacacgagc  tgcccaacc  aagagactc  ccctacccg  4260
agagcagcc  ggacatggc  gaggacctg  ctccctcca  gaggagcga  aacgaggac  4320
tttactaca  aagtatgcc  aatcttggg  ctggccgcc  gctccagat  tgctaccag  4380
tcagcagag  caatagcga  ggctacatc  tccccatta  caaagaagg  tgcatccca  4440
agggggacg  cagggaagg  cagatgcag  tggtaacaa  tctttaata  tacagctaa  4500
gaattccta  ggccacatg  aagtattaa  tgctaaaga  tgtgccagc  ggccctgca  4560
ctctcccca  ctcggccag  agaaccggc  ctgctggcc  gcggttctc  actgtagga  4620
aaaaaaatg  actgaacct  gcggttctg  gaattttta  aaaacatgc  aaaactttg  4680
atatacaca  agtatacta  attgaatta  ttgttacaa  gaaaaaaga  atgccaacc  4740
ggtatttta  gtttctgct  ctgtgtaga  agattgtaa  acaaacagg  gaccctccc  4800
gccatgatc  cgcggcagt  ggtgaactg  gtctgtaaa  agaacccta  cgttttggg  4860
tttttttgt  tgtttgttt  tttttgttt  tgttttgta  gcctgcatt  tattatata  4920
aagacgtag  ctttaagat  ctgtgggac  aattgactg  atcttactt  tcctgacaa  4980
acttggaaa  gcaggagag  gattctgca  ccgtttgca  ttccctgca  accttttac  5040
ttaaggcag  caccgaaac  atgtttaac  agtagcaat  aagccacag  ccttatctc  5100
tgtttcctc  actgtacaa  gaactgttc  catgaagaa  aaaaaagtt  atggctaaa  5160
aaaattata  tttgttcta  tgctagggt  aaaataaat  catttgtgt  caactgaga  5220
atcattaaa  taattttaa  aagagtttg  agaaaatat  gtgtcaagc  cttggttgc  5280
caaaatagg  gatgtctct  ctcccaccc  ccatggtga  tttgtgccc  tctttgttg  5340
ttcccactg  agacggtgt  tgctctgac  gcttagccc  ctttcttac  cttaaattt  5400
ttattgcca  aagagtgtg  tttatgggg  gaaaactct  tgaagtcct  ccatgcctt  5460
cacaaatgt  gggaaatct  gaggtcttg  gtcaaccct  tgtttattc  ggaacagag  5520
gcgaagggg  cactgggca  ttctcacaa  ctttctagt  aacaaaagg  gcctattct  5580
ttataaaaa  aaaaaaaaa  aa  5602



<210> 971
<211> 1488
<212> PRT
<213> Rattus norvegicus
<308> AF063102
<400> 971

Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Met Ile 
  1               5                  10                  15
Ile Ser Phe Ser Pro Asn Thr Glu Gly Phe Ser Arg Ala Ala Leu Pro 
             20                  25                  30
Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp 
         35                  40                  45
Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr 
     50                  55                  60
Gly Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu 
 65                  70                  75                  80
Asn Thr Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Thr Gln Arg 
                 85                  90                  95
Cys Asn Asn Arg Thr Gln Cys Val Val Val Thr Gly Ser Asp Val Phe 
             100                105                110
Pro Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu 
         115                120                125
Cys Val Pro Tyr Met Glu Gln Lys Val Phe Val Cys Pro Gly Thr Leu 
     130                135                140
Lys Ala Ile Val Asp Ser Pro Ser Ile Tyr Glu Ala Glu Gln Lys Ala 
 145                150                155                160
Gly Ala Trp Cys Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe 
                 165                170                175
Met Pro Trp Thr Pro Tyr Arg Thr Asp Thr Leu Ile Glu Tyr Ala Ser 
             180                185                190
Leu Glu Asp Phe Gln Asn Ser Arg Gln Thr Thr Thr Tyr Lys Leu Pro 
         195                200                205
Asn Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe 
     210                215                220
Phe Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr 
 225                230                235                240
Arg Ile Lys Ser Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp 
                 245                250                255
Thr Ser Pro Tyr Arg Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val 
             260                265                270
Asp Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly 
         275                280                285
Met Ile Val Ile Ser Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Ala 
     290                295                300
Thr Trp Glu Thr Thr Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met 
 305                310                315                320
Ile Cys Gly Val Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu 
                 325                330                335
Ser Glu Ala Gly Lys Asn Val Ile Asp Tyr Ile Tyr Asn Thr Arg Leu 
             340                345                350
Ser Arg Gly Glu His Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr 
         355                360                365
Ile Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp 
     370                375                380
Asn Asn Asn Phe Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp 
 385                390                395                400
Pro Ala Gln Val Pro Thr Thr Ala Val Thr Ile Thr Ser Ser Ala Glu 
                 405                410                415
Leu Phe Lys Thr Thr Val Ser Thr Thr Ser Ser Thr Ser Gln Arg Gly 
             420                425                430
Pro Val Ser Ser Thr Val Ala Gly Pro Gln Glu Gly Ser Arg Gly Thr 
         435                440                445
Lys Pro Pro Pro Ala Val Ser Thr Thr Lys Ile Pro Pro Val Thr Asn 
     450                455                460
Ile Phe Pro Leu Pro Glu Arg Phe Cys Glu Ala Leu Glu Met Lys Gly 
 465                470                475                480
Ile Lys Trp Pro Gln Thr Gln Arg Gly Met Met Val Glu Arg Pro Cys 
                 485                490                495
Pro Lys Gly Thr Arg Gly Thr Ala Ser Tyr Leu Cys Met Ala Ser Thr 
             500                505                510
Gly Thr Trp Asn Pro Lys Gly Pro Asp Leu Ser Asn Cys Thr Ser His 
         515                520                525
Trp Val Asn Gln Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala 
     530                535                540
Ser Leu Ala Asn Glu Leu Ala Lys His Thr Lys Gly Thr Val Phe Ala 
 545                550                555                560
Gly Asp Val Ser Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile 
                 565                570                575
Leu Asp Ala Gln Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala 
             580                585                590
Gly Arg Ser Tyr Asn Lys Leu Gln Lys Arg Glu Lys Thr Cys Arg Ala 
         595                600                605
Tyr Leu Lys Ala Ile Val Asp Thr Val Asp Asn Leu Leu Arg Ala Glu 
     610                615                620
Thr Leu Asp Cys Trp Lys His Met Asn Ser Ser Glu Gln Ala His Thr 
 625                630                635                640
Ala Thr Met Leu Leu Asp Thr Leu Glu Glu Gly Ala Phe Val Leu Ala 
                 645                650                655
Asp Asn Leu Leu Glu Pro Thr Arg Val Ser Met Pro Thr Asp Asn Ile 
             660                665                670
Val Leu Glu Val Ala Val Leu Ser Thr Glu Gly Gln Val Gln Asp Phe 
         675                680                685
Thr Phe His Leu Gly Phe Lys Gly Ala Phe Ser Ser Ile Gln Leu Ser 
     690                695                700
Ala Asn Thr Val Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Val Val 
 705                710                715                720
Phe Ile Ile Tyr Arg Ser Leu Gly Pro Phe Leu Ser Thr Glu Asn Ala 
                 725                730                735
Thr Val Lys Leu Gly Ala Asp Leu Leu Gly Arg Asn Ser Thr Ile Ala 
             740                745                750
Val Asn Ser His Val Leu Ser Val Ser Ile Asn Lys Glu Ser Ser Arg 
         755                760                765
Val Tyr Leu Thr Asp Pro Val Leu Phe Ser Met Pro His Ile Asp Ser 
     770                775                780
Asp Asn Tyr Phe Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg 
 785                790                795                800
Thr Met Met Gly Tyr Trp Ser Thr Gln Gly Cys Lys Leu Val Asp Thr 
                 805                810                815
Asn Lys Thr Arg Thr Thr Cys Ala Cys Ser His Leu Thr Asn Phe Ala 
             820                825                830
Ile Leu Met Ala His Arg Glu Ile Val Tyr Lys Asp Gly Val His Lys 
         835                840                845
Leu Leu Leu Thr Val Ile Thr Trp Val Gly Ile Val Val Ser Leu Val 
     850                855                860
Cys Leu Ala Ile Cys Ile Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln 
 865                870                875                880
Ser Asp Arg Asn Thr Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile 
                 885                890                895
Ala Glu Phe Ile Phe Leu Ile Gly Ile Asp Lys Thr Gln Tyr Thr Ile 
             900                905                910
Ala Cys Pro Val Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala 
         915                920                925
Phe Ser Trp Met Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val 
     930                935                940
Glu Val Phe Glu Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala 
 945                950                955                960
Gly Tyr Leu Phe Pro Ala Thr Val Val Gly Val Ser Ala Ala Ile Asp 
                 965                970                975
Ser Lys Ser Tyr Gly Thr Leu Glu Ala Cys Trp Leu His Val Asp Asn 
             980                985                990
Tyr Phe Ile Trp Ser Phe Ile Gly Pro Val Thr Phe Ile Ile Leu Leu 
         995                1000                1005
Asn Ile Ile Phe Leu Val Ile Thr Leu Cys Lys Met Val Lys His Ser 
     1010                1015                1020
Asn Thr Leu Lys Pro Asp Ser Ser Arg Leu Glu Asn Ile Asn Asn Tyr 
 1025                1030                1035                1040
Arg Val Cys Asp Gly Tyr Tyr Asn Thr Asp Leu Pro Gly Tyr Glu Asp 
                 1045                1050                1055
Asn Lys Pro Phe Ile Lys Ser Trp Val Leu Gly Ala Phe Ala Leu Leu 
             1060                1065                1070
Cys Leu Leu Gly Leu Thr Trp Ser Phe Gly Leu Leu Phe Val Asn Glu 
         1075                1080                1085
Glu Thr Val Val Met Ala Tyr Leu Phe Thr Ala Phe Asn Ala Phe Gln 
     1090                1095                1100
Gly Leu Phe Ile Phe Ile Phe His Cys Ala Leu Gln Lys Lys Val Arg 
 1105                1110                1115                1120
Lys Glu Tyr Ala Lys Cys Phe Arg His Trp Tyr Cys Cys Gly Gly Leu 
                 1125                1130                1135
Pro Thr Glu Ser Pro His Ser Ser Val Lys Ala Ser Thr Ser Arg Thr 
             1140                1145                1150
Ser Ala Arg Tyr Ser Ser Gly Thr Gln Ser Arg Ile Arg Arg Met Trp 
         1155                1160                1165
Asn Asp Thr Val Arg Lys Gln Ser Glu Ser Ser Phe Ile Ser Gly Asp 
     1170                1175                1180
Ile Asn Ser Thr Ser Thr Leu Asn Gln Gly Met Thr Gly Asn Tyr Leu 
 1185                1190                1195                1200
Leu Thr Asn Pro Leu Leu Arg Pro His Gly Thr Asn Asn Pro Tyr Asn 
                 1205                1210                1215
Thr Leu Leu Ala Glu Thr Val Val Cys Asn Ala Pro Ser Ala Pro Val 
             1220                1225                1230
Phe Asn Ser Pro Gly His Ser Leu Asn Asn Thr Arg Asp Thr Ser Ala 
         1235                1240                1245
Met Asp Thr Leu Pro Leu Asn Gly Asn Phe Asn Asn Ser Tyr Ser Leu 
     1250                1255                1260
Arg Lys Ala Asp Tyr His Asp Gly Val Gln Val Val Asp Cys Gly Leu 
 1265                1270                1275                1280
Ser Leu Asn Asp Thr Ala Phe Glu Lys Met Ile Ile Ser Glu Leu Val 
                 1285                1290                1295
His Asn Asn Leu Arg Gly Ser Asn Lys Thr His Asn Leu Glu Leu Lys 
             1300                1305                1310
Leu Pro Val Lys Pro Val Ile Gly Gly Ser Ser Ser Glu Asp Asp Ala 
         1315                1320                1325
Ile Val Ala Asp Ala Ser Ser Leu Met His Gly Asp Asn Pro Gly Leu 
     1330                1335                1340
Glu Phe Arg His Lys Glu Leu Glu Ala Pro Leu Ile Pro Gln Arg Thr 
 1345                1350                1355                1360
His Ser Leu Leu Tyr Gln Pro Gln Lys Lys Val Lys Pro Glu Ala Thr 
                 1365                1370                1375
Asp Ser Tyr Val Ser Gln Leu Thr Ala Glu Ala Asp Glu His Leu Gln 
             1380                1385                1390
Ser Pro Asn Arg Asp Ser Leu Tyr Thr Ser Met Pro Asn Leu Arg Asp 
         1395                1400                1405
Ser Pro Tyr Pro Glu Ser Ser Pro Asp Met Ala Glu Asp Leu Ser Pro 
     1410                1415                1420
Ser Arg Arg Ser Glu Asn Glu Asp Ile Tyr Tyr Lys Ser Met Pro Asn 
 1425                1430                1435                1440
Leu Gly Ala Gly Arg Gln Leu Gln Met Cys Tyr Gln Ile Ser Arg Gly 
                 1445                1450                1455
Asn Ser Asp Gly Tyr Ile Ile Pro Ile Asn Lys Glu Gly Cys Ile Pro 
             1460                1465                1470
Glu Gly Asp Val Arg Glu Gly Gln Met Gln Leu Val Thr Ser Leu Ter 
         1475                1480                1485



<210> 972
<211> 172
<212> DNA
<213> Homo sapiens
<308> AW238191
<400> 972

gcgtcgaca  acatgcaaa  actttgtat  tacacagag  atactaaat  gaattattt  60
ttacaaaga  aaaagaaat  ccaaccagg  attttacgt  tctgctgct  tgtagagag  120
ttgtaaaac  aacaagaga  cctccctcc  gtcgacgcg  ccgcggtcg  cg  172



<210> 973
<211> 1021
<212> PRT
<213> Homo sapiens
<308> BAA34506
<400> 973

Glu Gly Ser Lys Gly Thr Lys Pro Pro Pro Ala Val Ser Thr Thr Lys 
  1               5                  10                  15
Ile Pro Pro Ile Thr Asn Ile Phe Pro Leu Pro Glu Arg Phe Cys Glu 
             20                  25                  30
Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro Gln Thr Gln Arg Gly Met 
         35                  40                  45
Met Val Glu Arg Pro Cys Pro Lys Gly Thr Arg Gly Thr Ala Ser Tyr 
     50                  55                  60
Leu Cys Met Ile Ser Thr Gly Thr Trp Asn Pro Lys Gly Pro Asp Leu 
 65                  70                  75                  80
Ser Asn Cys Thr Ser His Trp Val Asn Gln Leu Ala Gln Lys Ile Arg 
                 85                  90                  95
Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn Glu Leu Ala Lys His Thr 
             100                105                110
Lys Gly Pro Val Phe Ala Gly Asp Val Ser Ser Ser Val Arg Leu Met 
         115                120                125
Glu Gln Leu Val Asp Ile Leu Asp Ala Gln Leu Gln Glu Leu Lys Pro 
     130                135                140
Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr Asn Lys Leu Gln Lys Arg 
 145                150                155                160
Glu Lys Thr Cys Arg Ala Tyr Leu Lys Ala Ile Val Asp Thr Val Asp 
                 165                170                175
Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys His Met Asn Ser 
             180                185                190
Ser Glu Gln Ala His Thr Ala Thr Met Leu Leu Asp Thr Leu Glu Glu 
         195                200                205
Gly Ala Phe Val Leu Ala Asp Asn Leu Leu Glu Pro Thr Arg Val Ser 
     210                215                220
Met Pro Thr Glu Asn Ile Val Leu Glu Val Ala Val Leu Ser Thr Glu 
 225                230                235                240
Gly Gln Ile Gln Asp Phe Lys Phe Pro Leu Gly Ile Lys Gly Ala Gly 
                 245                250                255
Ser Ser Ile Gln Leu Ser Ala Asn Thr Val Lys Gln Asn Ser Arg Asn 
             260                265                270
Gly Leu Ala Lys Leu Val Phe Ile Ile Tyr Arg Ser Leu Gly Gln Phe 
         275                280                285
Leu Ser Thr Glu Asn Ala Thr Ile Lys Leu Gly Ala Asp Phe Ile Gly 
     290                295                300
Arg Asn Ser Thr Ile Ala Val Asn Ser His Val Ile Ser Val Ser Ile 
 305                310                315                320
Asn Lys Glu Ser Ser Arg Val Tyr Leu Thr Asp Pro Val Leu Phe Thr 
                 325                330                335
Leu Pro His Ile Asp Pro Asp Asn Tyr Phe Asn Ala Asn Cys Ser Phe 
             340                345                350
Trp Asn Tyr Ser Glu Arg Thr Met Met Gly Tyr Trp Ser Thr Gln Gly 
         355                360                365
Cys Lys Leu Val Asp Thr Asn Lys Thr Arg Thr Thr Cys Ala Cys Ser 
     370                375                380
His Leu Thr Asn Phe Ala Ile Leu Met Ala His Arg Glu Ile Ala Tyr 
 385                390                395                400
Lys Asp Gly Val His Glu Leu Leu Leu Thr Val Ile Thr Trp Val Gly 
                 405                410                415
Ile Val Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Phe Thr Phe Cys 
             420                425                430
Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Thr Ile His Lys Asn Leu 
         435                440                445
Cys Ile Asn Leu Phe Ile Ala Glu Phe Ile Phe Leu Ile Gly Ile Asp 
     450                455                460
Lys Thr Lys Tyr Ala Ile Ala Cys Pro Ile Phe Ala Gly Leu Leu His 
 465                470                475                480
Phe Phe Phe Leu Ala Ala Phe Ala Trp Met Cys Leu Glu Gly Val Gln 
                 485                490                495
Leu Tyr Leu Met Leu Val Glu Val Phe Glu Ser Glu Tyr Ser Arg Lys 
             500                505                510
Lys Tyr Tyr Tyr Val Ala Gly Tyr Leu Phe Pro Ala Thr Val Val Gly 
         515                520                525
Val Ser Ala Ala Ile Asp Tyr Lys Ser Tyr Gly Thr Glu Lys Ala Cys 
     530                535                540
Trp Leu His Val Asp Asn Tyr Phe Ile Trp Ser Phe Ile Gly Pro Val 
 545                550                555                560
Thr Phe Ile Ile Leu Leu Asn Ile Ile Phe Leu Val Ile Thr Leu Cys 
                 565                570                575
Lys Met Val Lys His Ser Asn Thr Leu Lys Pro Asp Ser Ser Arg Leu 
             580                585                590
Glu Asn Ile Lys Ser Trp Val Leu Gly Ala Phe Ala Leu Leu Cys Leu 
         595                600                605
Leu Gly Leu Thr Trp Ser Phe Gly Leu Leu Phe Ile Asn Glu Glu Thr 
     610                615                620
Ile Val Met Ala Tyr Leu Phe Thr Ile Phe Asn Ala Phe Gln Gly Val 
 625                630                635                640
Phe Ile Phe Ile Phe His Cys Ala Leu Gln Lys Lys Val Arg Lys Glu 
                 645                650                655
Tyr Gly Lys Cys Phe Arg His Ser Tyr Cys Cys Gly Gly Leu Pro Thr 
             660                665                670
Glu Ser Pro His Ser Ser Val Lys Ala Ser Thr Thr Arg Thr Ser Ala 
         675                680                685
Arg Tyr Ser Ser Gly Thr Gln Ser Arg Ile Arg Arg Met Trp Asn Asp 
     690                695                700
Thr Val Arg Lys Gln Ser Glu Ser Ser Phe Ile Ser Gly Asp Ile Asn 
 705                710                715                720
Ser Thr Ser Thr Leu Asn Gln Gly Met Thr Gly Asn Tyr Leu Leu Thr 
                 725                730                735
Asn Pro Leu Leu Arg Pro His Gly Thr Asn Asn Pro Tyr Asn Thr Leu 
             740                745                750
Leu Ala Glu Thr Val Val Cys Asn Ala Pro Ser Ala Pro Val Phe Asn 
         755                760                765
Ser Pro Gly His Ser Leu Asn Asn Ala Arg Asp Thr Ser Ala Met Asp 
     770                775                780
Thr Leu Pro Leu Asn Gly Asn Phe Asn Asn Ser Tyr Ser Leu His Lys 
 785                790                795                800
Gly Asp Tyr Asn Asp Ser Val Gln Val Val Asp Cys Gly Leu Ser Leu 
                 805                810                815
Asn Asp Thr Ala Phe Glu Lys Met Ile Ile Ser Glu Leu Val His Asn 
             820                825                830
Asn Leu Arg Gly Ser Ser Lys Thr His Asn Leu Glu Leu Thr Leu Pro 
         835                840                845
Val Lys Pro Val Ile Gly Gly Ser Ser Ser Glu Asp Asp Ala Ile Val 
     850                855                860
Ala Asp Ala Ser Ser Leu Met His Ser Asp Asn Pro Gly Leu Glu Leu 
 865                870                875                880
His His Lys Glu Leu Glu Ala Pro Leu Ile Pro Gln Arg Thr His Ser 
                 885                890                895
Leu Leu Tyr Gln Pro Gln Lys Lys Val Lys Ser Glu Gly Thr Asp Ser 
             900                905                910
Tyr Val Ser Gln Leu Thr Ala Glu Ala Glu Asp His Leu Gln Ser Pro 
         915                920                925
Asn Arg Asp Ser Leu Tyr Thr Ser Met Pro Asn Leu Arg Asp Ser Pro 
     930                935                940
Tyr Pro Glu Ser Ser Pro Asp Met Glu Glu Asp Leu Ser Pro Ser Arg 
 945                950                955                960
Arg Ser Glu Asn Glu Asp Ile Tyr Tyr Lys Ser Met Pro Asn Leu Gly 
                 965                970                975
Ala Gly His Gln Leu Gln Met Cys Tyr Gln Ile Ser Arg Gly Asn Ser 
             980                985                990
Asp Gly Tyr Ile Ile Pro Ile Asn Lys Glu Gly Cys Ile Pro Glu Gly 
         995                1000                1005
Asp Val Arg Glu Gly Gln Met Gln Leu Val Thr Ser Leu 
     1010                1015                1020



<210> 974
<211> 5602
<212> DNA
<213> Rattus norvegicus
<308> AF063102
<400> 974

gaaaatatt  aaagggatc  ataatggtg  cttctggtt  cagaatgcg  agtctctgg  60
ttatcatga  aatcagttt  tcaccgaat  ccgaaggtt  cagcagagc  gccttgcca  120
tcgggttag  tagacgaga  ctgtcctgt  aaggttatt  tatagacct  cgatgtccg  180
gcagtgacg  catcatgat  gagagcgca  actacggtc  gacggacga  aagatctgc  240
acgcagacc  ctttcagat  gagaacaca  actgctacc  ccctgatgc  ttcaaaatc  300
tgactcaaa  gtgcaacaa  cgaacacag  gtgtagtag  taccgggtc  gatgtattt  360
ctgatccat  tcccggaac  tacaaatac  ttgaagttc  atatgaatg  gtcccttac  420
tggagcaaa  agtytttgt  tgtcctgga  ccttgaaag  aattgtgga  tctccaagt  480
tctatgaag  tgagcaaaa  gcaggtgct  ggtgcaagg  cccccttca  gctgcagat  540
aaatttatt  tatgccctg  actccctac  gcaccgata  cttaataga  tatgcttct  600
tagaagatt  tcaaaacag  cgccagaca  caacataca  acttccaaa  cgagtggac  660
gtactggat  tgtggtgta  gacggggca  tcttcttca  caaagaaag  acgagaaac  720
ttgttaaat  tgacttgag  actagaatc  agagtgggg  ggccataat  aactacgcc  780
actaccatg  cacctcacc  tacagatgg  gggggaaga  tgacattga  ctggcagtg  840
atgaaaatg  cttgtgggt  atctacgcc  ccgagcaga  caacggaat  atcgtgatt  900
gccagctca  tccgtacac  ctccgattc  aagcaacct  ggagacgac  tatgacaag  960
gtgcggcgt  caatgcttt  atgatatgc  gggtcctct  cgtggtcag  tcagtgtac  1020
aagacaatg  aagcgaagc  ggcaagaac  tcatcgact  catttacaa  acaaggttg  1080
gccggggag  gcacgtgga  gttcccttc  ccaaccagt  ccagtacat  gctgcagtg  1140
attacaacc  aagagacaa  caactctac  tatggaaca  taactttat  ttacggtat  1200
ctctggagt  tggtccacc  gaccctgcc  aagtgccta  cacagctgt  acaataact  1260
cttcagctg  gctgttcaa  accacagtg  caaccacaa  cagtacttc  cagagaggc  1320
ccgtgagca  cacagtcgc  ggtcctcag  aaggaagcc  agggacaaa  ccacctcca  1380
cagtctcta  aaccaaaat  cctcctgta  caaatattt  tcccctgcc  gagagattc  1440
gcgaagcgt  agaaatgaa  gggataaag  ggcctcaga  acaaagggg  atgatggtt  1500
agcgaccgt  tcccaaggg  acaagagga  cggcctcgt  tctctgcat  gcttccaca  1560
gaacctgga  cccgaaggg  ccggatctt  gcaactgca  ctctcactg  gtgaatcag  1620
tggcccaga  gatcagaag  ggagagaat  ctgcaagtc  ggccaacga  ctggctaag  1680
acaccaagg  gacggtgtt  gctggggat  tgagctcct  tgtgaggct  atggaacag  1740
tggtggaca  cctggatgc  cagctgcag  agctgaaac  gagcgagaa  gactcggcc  1800
ggaggagtt  taacaagct  caaaaacga  agaagacat  cagggctta  cttaaggcc  1860
ttgtggaca  agtagataa  cttctgaga  ccgagactt  ggactgctg  aaacacatg  1920
attcctcag  gcaggcgca  acagccacc  tgctgttgg  caccttgga  gaaggagca  1980
ttgtcctgg  agacaacct  ttggaacca  cccgggtct  aatgccaac  gataatatt  2040
ttctagaag  cgctgtcct  agcacggaa  gacaggtcc  agacttcac  ttccatctc  2100
gcttcaagg  ggccttcag  tccatccag  tctcagcca  caccgtcaa  caaaacagc  2160
gaaacgggc  ggcaaaggt  gtattcatc  tttaccgga  tctgggacc  ttcctgagc  2220
ccgaaaatg  gaccgtcaa  ctgggcgca  acctcctgg  tcggaacag  accatcgca  2280
tgaactcgc  cgtcctttc  gtctccatc  ataaggagt  cagccgtgt  tacttgaca  2340
acccggtgc  tttttcaat  ccacacatt  attctgaca  ttatttcaa  gcaaactgc  2400
ccttctgga  ctactcaga  agaaccatg  tgggatatt  gtctaccca  ggctgcaag  2460
tggttgaca  taataaaac  cgcacgacg  gtgcatgca  ccacctaac  aattttgct  2520
ttctcatgg  ccacaggga  attgtgtac  aagatggcg  ccacaaatt  ctgctgaca  2580
tcatcacct  ggtgggcat  gttgtctcc  tcgtctgcc  ggctatctg  atcttcacc  2640
tctgcttct  ccgaggcct  caaagcgac  gcaacacga  ccacaagaa  ctgtgtatc  2700
acctcttca  cgctgagtt  attttccta  taggcattg  taaaacaca  tacacgatt  2760
cgtgccccg  gtttgcagg  ctcctgcac  ttttcttcc  ggctgcttt  tcctggatg  2820
gcctagaag  tgtgcagct  tacctcatg  tggttgaag  tttcgagag  gaatactca  2880
ggaagaagt  ttactatgt  gccgggtac  tcttccctg  cacagtggt  ggtgtttca  2940
ctgctatcg  ctccaagag  tacgggaca  tagaggctt  ctggcttca  gttgataac  3000
atttcatat  gagtttcat  gggcctgtt  ctttcatca  tctgctaaa  attattttc  3060
tggtgatca  gctgtgcaa  atggtgaaa  attcaaaca  tttgaaacc  gattctagc  3120
ggttggaaa  cattaataa  taccgtgtt  gtgatggat  ctataatac  gacttacct  3180
gctatgaag  taataagcc  tttatcaag  cttgggtgc  cggtgcgtt  gccctgctg  3240
gtctcctgg  cctaacctg  tcctttggg  tgctttttg  taacgagga  accgttgtc  3300
tggcttatc  cttcaccgc  tttaatgct  tccagggac  gtttatttt  atcttccac  3360
gtgctcttc  aaagaaagt  cggaaagag  atgccaagt  cttcagaca  tggtactgc  3420
gtggcggcc  cccgaccga  agcccgcac  gctctgtaa  ggcgtccac  tcccgcacc  3480
gtgctcgct  ctcctctgg  acacagagc  gtataagaa  gatgtggaa  gacaccgtg  3540
ggaagcagt  tgaatcgtc  tttatctca  gtgacatca  tagcacttc  acccttaat  3600
aaggaatga  tggcaatta  ctactaaca  accctcttc  tcgacccca  ggcactaac  3660
acccctata  cacattgct  gctgaaaca  ttgtatgta  tgccccttc  gcgcccgtg  3720
ttaactcac  aggacattc  ctgaacaat  cccgggaca  cagcgccat  gatactcta  3780
cgctaaatg  taacttcaa  aacagctac  ccctgcgca  ggccgacta  cacgacggc  3840
tgcaggttg  ggactgtgg  ctaagtctg  acgacaccg  gtttgagaa  atgatcatt  3900
cagagttag  gcacaacaa  ctccggggt  gcaacaaaa  ccacaactt  gagctcaag  3960
tcccagtta  acccgtgat  ggcggcagc  gcagcgaag  tgacgcgat  gtggccgac  4020
cctcatctt  gatgcacgg  gataaccca  ggctggaat  ccgccacaa  gagctggag  4080
caccgctca  ccctcagcg  actcactcg  ttctgtacc  accccagaa  aaagtgaaa  4140
ccgaggcaa  cgacagcta  gtctcccag  tgacggccg  ggccgacga  cacctccag  4200
cccccaaca  agactctct  tacacgagc  tgcccaacc  aagagactc  ccctacccg  4260
agagcagcc  ggacatggc  gaggacctg  ctccctcca  gaggagcga  aacgaggac  4320
tttactaca  aagtatgcc  aatcttggg  ctggccgcc  gctccagat  tgctaccag  4380
tcagcagag  caatagcga  ggctacatc  tccccatta  caaagaagg  tgcatccca  4440
agggggacg  cagggaagg  cagatgcag  tggtaacaa  tctttaata  tacagctaa  4500
gaattccta  ggccacatg  aagtattaa  tgctaaaga  tgtgccagc  ggccctgca  4560
ctctcccca  ctcggccag  agaaccggc  ctgctggcc  gcggttctc  actgtagga  4620
aaaaaaatg  actgaacct  gcggttctg  gaattttta  aaaacatgc  aaaactttg  4680
atatacaca  agtatacta  attgaatta  ttgttacaa  gaaaaaaga  atgccaacc  4740
ggtatttta  gtttctgct  ctgtgtaga  agattgtaa  acaaacagg  gaccctccc  4800
gccatgatc  cgcggcagt  ggtgaactg  gtctgtaaa  agaacccta  cgttttggg  4860
tttttttgt  tgtttgttt  tttttgttt  tgttttgta  gcctgcatt  tattatata  4920
aagacgtag  ctttaagat  ctgtgggac  aattgactg  atcttactt  tcctgacaa  4980
acttggaaa  gcaggagag  gattctgca  ccgtttgca  ttccctgca  accttttac  5040
ttaaggcag  caccgaaac  atgtttaac  agtagcaat  aagccacag  ccttatctc  5100
tgtttcctc  actgtacaa  gaactgttc  catgaagaa  aaaaaagtt  atggctaaa  5160
aaaattata  tttgttcta  tgctagggt  aaaataaat  catttgtgt  caactgaga  5220
atcattaaa  taattttaa  aagagtttg  agaaaatat  gtgtcaagc  cttggttgc  5280
caaaatagg  gatgtctct  ctcccaccc  ccatggtga  tttgtgccc  tctttgttg  5340
ttcccactg  agacggtgt  tgctctgac  gcttagccc  ctttcttac  cttaaattt  5400
ttattgcca  aagagtgtg  tttatgggg  gaaaactct  tgaagtcct  ccatgcctt  5460
cacaaatgt  gggaaatct  gaggtcttg  gtcaaccct  tgtttattc  ggaacagag  5520
gcgaagggg  cactgggca  ttctcacaa  ctttctagt  aacaaaagg  gcctattct  5580
ttataaaaa  aaaaaaaaa  aa  5602



<210> 975
<211> 1488
<212> PRT
<213> Rattus norvegicus
<308> AF063102
<400> 975

Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Met Ile 
  1               5                  10                  15
Ile Ser Phe Ser Pro Asn Thr Glu Gly Phe Ser Arg Ala Ala Leu Pro 
             20                  25                  30
Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp 
         35                  40                  45
Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr 
     50                  55                  60
Gly Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu 
 65                  70                  75                  80
Asn Thr Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Thr Gln Arg 
                 85                  90                  95
Cys Asn Asn Arg Thr Gln Cys Val Val Val Thr Gly Ser Asp Val Phe 
             100                105                110
Pro Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu 
         115                120                125
Cys Val Pro Tyr Met Glu Gln Lys Val Phe Val Cys Pro Gly Thr Leu 
     130                135                140
Lys Ala Ile Val Asp Ser Pro Ser Ile Tyr Glu Ala Glu Gln Lys Ala 
 145                150                155                160
Gly Ala Trp Cys Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe 
                 165                170                175
Met Pro Trp Thr Pro Tyr Arg Thr Asp Thr Leu Ile Glu Tyr Ala Ser 
             180                185                190
Leu Glu Asp Phe Gln Asn Ser Arg Gln Thr Thr Thr Tyr Lys Leu Pro 
         195                200                205
Asn Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe 
     210                215                220
Phe Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr 
 225                230                235                240
Arg Ile Lys Ser Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp 
                 245                250                255
Thr Ser Pro Tyr Arg Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val 
             260                265                270
Asp Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly 
         275                280                285
Met Ile Val Ile Ser Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Ala 
     290                295                300
Thr Trp Glu Thr Thr Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met 
 305                310                315                320
Ile Cys Gly Val Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu 
                 325                330                335
Ser Glu Ala Gly Lys Asn Val Ile Asp Tyr Ile Tyr Asn Thr Arg Leu 
             340                345                350
Ser Arg Gly Glu His Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr 
         355                360                365
Ile Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp 
     370                375                380
Asn Asn Asn Phe Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp 
 385                390                395                400
Pro Ala Gln Val Pro Thr Thr Ala Val Thr Ile Thr Ser Ser Ala Glu 
                 405                410                415
Leu Phe Lys Thr Thr Val Ser Thr Thr Ser Ser Thr Ser Gln Arg Gly 
             420                425                430
Pro Val Ser Ser Thr Val Ala Gly Pro Gln Glu Gly Ser Arg Gly Thr 
         435                440                445
Lys Pro Pro Pro Ala Val Ser Thr Thr Lys Ile Pro Pro Val Thr Asn 
     450                455                460
Ile Phe Pro Leu Pro Glu Arg Phe Cys Glu Ala Leu Glu Met Lys Gly 
 465                470                475                480
Ile Lys Trp Pro Gln Thr Gln Arg Gly Met Met Val Glu Arg Pro Cys 
                 485                490                495
Pro Lys Gly Thr Arg Gly Thr Ala Ser Tyr Leu Cys Met Ala Ser Thr 
             500                505                510
Gly Thr Trp Asn Pro Lys Gly Pro Asp Leu Ser Asn Cys Thr Ser His 
         515                520                525
Trp Val Asn Gln Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala 
     530                535                540
Ser Leu Ala Asn Glu Leu Ala Lys His Thr Lys Gly Thr Val Phe Ala 
 545                550                555                560
Gly Asp Val Ser Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile 
                 565                570                575
Leu Asp Ala Gln Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala 
             580                585                590
Gly Arg Ser Tyr Asn Lys Leu Gln Lys Arg Glu Lys Thr Cys Arg Ala 
         595                600                605
Tyr Leu Lys Ala Ile Val Asp Thr Val Asp Asn Leu Leu Arg Ala Glu 
     610                615                620
Thr Leu Asp Cys Trp Lys His Met Asn Ser Ser Glu Gln Ala His Thr 
 625                630                635                640
Ala Thr Met Leu Leu Asp Thr Leu Glu Glu Gly Ala Phe Val Leu Ala 
                 645                650                655
Asp Asn Leu Leu Glu Pro Thr Arg Val Ser Met Pro Thr Asp Asn Ile 
             660                665                670
Val Leu Glu Val Ala Val Leu Ser Thr Glu Gly Gln Val Gln Asp Phe 
         675                680                685
Thr Phe His Leu Gly Phe Lys Gly Ala Phe Ser Ser Ile Gln Leu Ser 
     690                695                700
Ala Asn Thr Val Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Val Val 
 705                710                715                720
Phe Ile Ile Tyr Arg Ser Leu Gly Pro Phe Leu Ser Thr Glu Asn Ala 
                 725                730                735
Thr Val Lys Leu Gly Ala Asp Leu Leu Gly Arg Asn Ser Thr Ile Ala 
             740                745                750
Val Asn Ser His Val Leu Ser Val Ser Ile Asn Lys Glu Ser Ser Arg 
         755                760                765
Val Tyr Leu Thr Asp Pro Val Leu Phe Ser Met Pro His Ile Asp Ser 
     770                775                780
Asp Asn Tyr Phe Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg 
 785                790                795                800
Thr Met Met Gly Tyr Trp Ser Thr Gln Gly Cys Lys Leu Val Asp Thr 
                 805                810                815
Asn Lys Thr Arg Thr Thr Cys Ala Cys Ser His Leu Thr Asn Phe Ala 
             820                825                830
Ile Leu Met Ala His Arg Glu Ile Val Tyr Lys Asp Gly Val His Lys 
         835                840                845
Leu Leu Leu Thr Val Ile Thr Trp Val Gly Ile Val Val Ser Leu Val 
     850                855                860
Cys Leu Ala Ile Cys Ile Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln 
 865                870                875                880
Ser Asp Arg Asn Thr Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile 
                 885                890                895
Ala Glu Phe Ile Phe Leu Ile Gly Ile Asp Lys Thr Gln Tyr Thr Ile 
             900                905                910
Ala Cys Pro Val Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala 
         915                920                925
Phe Ser Trp Met Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val 
     930                935                940
Glu Val Phe Glu Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala 
 945                950                955                960
Gly Tyr Leu Phe Pro Ala Thr Val Val Gly Val Ser Ala Ala Ile Asp 
                 965                970                975
Ser Lys Ser Tyr Gly Thr Leu Glu Ala Cys Trp Leu His Val Asp Asn 
             980                985                990
Tyr Phe Ile Trp Ser Phe Ile Gly Pro Val Thr Phe Ile Ile Leu Leu 
         995                1000                1005
Asn Ile Ile Phe Leu Val Ile Thr Leu Cys Lys Met Val Lys His Ser 
     1010                1015                1020
Asn Thr Leu Lys Pro Asp Ser Ser Arg Leu Glu Asn Ile Asn Asn Tyr 
 1025                1030                1035                1040
Arg Val Cys Asp Gly Tyr Tyr Asn Thr Asp Leu Pro Gly Tyr Glu Asp 
                 1045                1050                1055
Asn Lys Pro Phe Ile Lys Ser Trp Val Leu Gly Ala Phe Ala Leu Leu 
             1060                1065                1070
Cys Leu Leu Gly Leu Thr Trp Ser Phe Gly Leu Leu Phe Val Asn Glu 
         1075                1080                1085
Glu Thr Val Val Met Ala Tyr Leu Phe Thr Ala Phe Asn Ala Phe Gln 
     1090                1095                1100
Gly Leu Phe Ile Phe Ile Phe His Cys Ala Leu Gln Lys Lys Val Arg 
 1105                1110                1115                1120
Lys Glu Tyr Ala Lys Cys Phe Arg His Trp Tyr Cys Cys Gly Gly Leu 
                 1125                1130                1135
Pro Thr Glu Ser Pro His Ser Ser Val Lys Ala Ser Thr Ser Arg Thr 
             1140                1145                1150
Ser Ala Arg Tyr Ser Ser Gly Thr Gln Ser Arg Ile Arg Arg Met Trp 
         1155                1160                1165
Asn Asp Thr Val Arg Lys Gln Ser Glu Ser Ser Phe Ile Ser Gly Asp 
     1170                1175                1180
Ile Asn Ser Thr Ser Thr Leu Asn Gln Gly Met Thr Gly Asn Tyr Leu 
 1185                1190                1195                1200
Leu Thr Asn Pro Leu Leu Arg Pro His Gly Thr Asn Asn Pro Tyr Asn 
                 1205                1210                1215
Thr Leu Leu Ala Glu Thr Val Val Cys Asn Ala Pro Ser Ala Pro Val 
             1220                1225                1230
Phe Asn Ser Pro Gly His Ser Leu Asn Asn Thr Arg Asp Thr Ser Ala 
         1235                1240                1245
Met Asp Thr Leu Pro Leu Asn Gly Asn Phe Asn Asn Ser Tyr Ser Leu 
     1250                1255                1260
Arg Lys Ala Asp Tyr His Asp Gly Val Gln Val Val Asp Cys Gly Leu 
 1265                1270                1275                1280
Ser Leu Asn Asp Thr Ala Phe Glu Lys Met Ile Ile Ser Glu Leu Val 
                 1285                1290                1295
His Asn Asn Leu Arg Gly Ser Asn Lys Thr His Asn Leu Glu Leu Lys 
             1300                1305                1310
Leu Pro Val Lys Pro Val Ile Gly Gly Ser Ser Ser Glu Asp Asp Ala 
         1315                1320                1325
Ile Val Ala Asp Ala Ser Ser Leu Met His Gly Asp Asn Pro Gly Leu 
     1330                1335                1340
Glu Phe Arg His Lys Glu Leu Glu Ala Pro Leu Ile Pro Gln Arg Thr 
 1345                1350                1355                1360
His Ser Leu Leu Tyr Gln Pro Gln Lys Lys Val Lys Pro Glu Ala Thr 
                 1365                1370                1375
Asp Ser Tyr Val Ser Gln Leu Thr Ala Glu Ala Asp Glu His Leu Gln 
             1380                1385                1390
Ser Pro Asn Arg Asp Ser Leu Tyr Thr Ser Met Pro Asn Leu Arg Asp 
         1395                1400                1405
Ser Pro Tyr Pro Glu Ser Ser Pro Asp Met Ala Glu Asp Leu Ser Pro 
     1410                1415                1420
Ser Arg Arg Ser Glu Asn Glu Asp Ile Tyr Tyr Lys Ser Met Pro Asn 
 1425                1430                1435                1440
Leu Gly Ala Gly Arg Gln Leu Gln Met Cys Tyr Gln Ile Ser Arg Gly 
                 1445                1450                1455
Asn Ser Asp Gly Tyr Ile Ile Pro Ile Asn Lys Glu Gly Cys Ile Pro 
             1460                1465                1470
Glu Gly Asp Val Arg Glu Gly Gln Met Gln Leu Val Thr Ser Leu Ter 
         1475                1480                1485



<210> 976
<211> 172
<212> DNA
<213> Homo sapiens
<308> AW238191
<400> 976

gcgtcgaca  acatgcaaa  actttgtat  tacacagag  atactaaat  gaattattt  60
ttacaaaga  aaaagaaat  ccaaccagg  attttacgt  tctgctgct  tgtagagag  120
ttgtaaaac  aacaagaga  cctccctcc  gtcgacgcg  ccgcggtcg  cg  172



<210> 977
<211> 1021
<212> PRT
<213> Homo sapiens
<308> BAA34506
<400> 977

Glu Gly Ser Lys Gly Thr Lys Pro Pro Pro Ala Val Ser Thr Thr Lys 
  1               5                  10                  15
Ile Pro Pro Ile Thr Asn Ile Phe Pro Leu Pro Glu Arg Phe Cys Glu 
             20                  25                  30
Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro Gln Thr Gln Arg Gly Met 
         35                  40                  45
Met Val Glu Arg Pro Cys Pro Lys Gly Thr Arg Gly Thr Ala Ser Tyr 
     50                  55                  60
Leu Cys Met Ile Ser Thr Gly Thr Trp Asn Pro Lys Gly Pro Asp Leu 
 65                  70                  75                  80
Ser Asn Cys Thr Ser His Trp Val Asn Gln Leu Ala Gln Lys Ile Arg 
                 85                  90                  95
Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn Glu Leu Ala Lys His Thr 
             100                105                110
Lys Gly Pro Val Phe Ala Gly Asp Val Ser Ser Ser Val Arg Leu Met 
         115                120                125
Glu Gln Leu Val Asp Ile Leu Asp Ala Gln Leu Gln Glu Leu Lys Pro 
     130                135                140
Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr Asn Lys Leu Gln Lys Arg 
 145                150                155                160
Glu Lys Thr Cys Arg Ala Tyr Leu Lys Ala Ile Val Asp Thr Val Asp 
                 165                170                175
Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys His Met Asn Ser 
             180                185                190
Ser Glu Gln Ala His Thr Ala Thr Met Leu Leu Asp Thr Leu Glu Glu 
         195                200                205
Gly Ala Phe Val Leu Ala Asp Asn Leu Leu Glu Pro Thr Arg Val Ser 
     210                215                220
Met Pro Thr Glu Asn Ile Val Leu Glu Val Ala Val Leu Ser Thr Glu 
 225                230                235                240
Gly Gln Ile Gln Asp Phe Lys Phe Pro Leu Gly Ile Lys Gly Ala Gly 
                 245                250                255
Ser Ser Ile Gln Leu Ser Ala Asn Thr Val Lys Gln Asn Ser Arg Asn 
             260                265                270
Gly Leu Ala Lys Leu Val Phe Ile Ile Tyr Arg Ser Leu Gly Gln Phe 
         275                280                285
Leu Ser Thr Glu Asn Ala Thr Ile Lys Leu Gly Ala Asp Phe Ile Gly 
     290                295                300
Arg Asn Ser Thr Ile Ala Val Asn Ser His Val Ile Ser Val Ser Ile 
 305                310                315                320
Asn Lys Glu Ser Ser Arg Val Tyr Leu Thr Asp Pro Val Leu Phe Thr 
                 325                330                335
Leu Pro His Ile Asp Pro Asp Asn Tyr Phe Asn Ala Asn Cys Ser Phe 
             340                345                350
Trp Asn Tyr Ser Glu Arg Thr Met Met Gly Tyr Trp Ser Thr Gln Gly 
         355                360                365
Cys Lys Leu Val Asp Thr Asn Lys Thr Arg Thr Thr Cys Ala Cys Ser 
     370                375                380
His Leu Thr Asn Phe Ala Ile Leu Met Ala His Arg Glu Ile Ala Tyr 
 385                390                395                400
Lys Asp Gly Val His Glu Leu Leu Leu Thr Val Ile Thr Trp Val Gly 
                 405                410                415
Ile Val Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Phe Thr Phe Cys 
             420                425                430
Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Thr Ile His Lys Asn Leu 
         435                440                445
Cys Ile Asn Leu Phe Ile Ala Glu Phe Ile Phe Leu Ile Gly Ile Asp 
     450                455                460
Lys Thr Lys Tyr Ala Ile Ala Cys Pro Ile Phe Ala Gly Leu Leu His 
 465                470                475                480
Phe Phe Phe Leu Ala Ala Phe Ala Trp Met Cys Leu Glu Gly Val Gln 
                 485                490                495
Leu Tyr Leu Met Leu Val Glu Val Phe Glu Ser Glu Tyr Ser Arg Lys 
             500                505                510
Lys Tyr Tyr Tyr Val Ala Gly Tyr Leu Phe Pro Ala Thr Val Val Gly 
         515                520                525
Val Ser Ala Ala Ile Asp Tyr Lys Ser Tyr Gly Thr Glu Lys Ala Cys 
     530                535                540
Trp Leu His Val Asp Asn Tyr Phe Ile Trp Ser Phe Ile Gly Pro Val 
 545                550                555                560
Thr Phe Ile Ile Leu Leu Asn Ile Ile Phe Leu Val Ile Thr Leu Cys 
                 565                570                575
Lys Met Val Lys His Ser Asn Thr Leu Lys Pro Asp Ser Ser Arg Leu 
             580                585                590
Glu Asn Ile Lys Ser Trp Val Leu Gly Ala Phe Ala Leu Leu Cys Leu 
         595                600                605
Leu Gly Leu Thr Trp Ser Phe Gly Leu Leu Phe Ile Asn Glu Glu Thr 
     610                615                620
Ile Val Met Ala Tyr Leu Phe Thr Ile Phe Asn Ala Phe Gln Gly Val 
 625                630                635                640
Phe Ile Phe Ile Phe His Cys Ala Leu Gln Lys Lys Val Arg Lys Glu 
                 645                650                655
Tyr Gly Lys Cys Phe Arg His Ser Tyr Cys Cys Gly Gly Leu Pro Thr 
             660                665                670
Glu Ser Pro His Ser Ser Val Lys Ala Ser Thr Thr Arg Thr Ser Ala 
         675                680                685
Arg Tyr Ser Ser Gly Thr Gln Ser Arg Ile Arg Arg Met Trp Asn Asp 
     690                695                700
Thr Val Arg Lys Gln Ser Glu Ser Ser Phe Ile Ser Gly Asp Ile Asn 
 705                710                715                720
Ser Thr Ser Thr Leu Asn Gln Gly Met Thr Gly Asn Tyr Leu Leu Thr 
                 725                730                735
Asn Pro Leu Leu Arg Pro His Gly Thr Asn Asn Pro Tyr Asn Thr Leu 
             740                745                750
Leu Ala Glu Thr Val Val Cys Asn Ala Pro Ser Ala Pro Val Phe Asn 
         755                760                765
Ser Pro Gly His Ser Leu Asn Asn Ala Arg Asp Thr Ser Ala Met Asp 
     770                775                780
Thr Leu Pro Leu Asn Gly Asn Phe Asn Asn Ser Tyr Ser Leu His Lys 
 785                790                795                800
Gly Asp Tyr Asn Asp Ser Val Gln Val Val Asp Cys Gly Leu Ser Leu 
                 805                810                815
Asn Asp Thr Ala Phe Glu Lys Met Ile Ile Ser Glu Leu Val His Asn 
             820                825                830
Asn Leu Arg Gly Ser Ser Lys Thr His Asn Leu Glu Leu Thr Leu Pro 
         835                840                845
Val Lys Pro Val Ile Gly Gly Ser Ser Ser Glu Asp Asp Ala Ile Val 
     850                855                860
Ala Asp Ala Ser Ser Leu Met His Ser Asp Asn Pro Gly Leu Glu Leu 
 865                870                875                880
His His Lys Glu Leu Glu Ala Pro Leu Ile Pro Gln Arg Thr His Ser 
                 885                890                895
Leu Leu Tyr Gln Pro Gln Lys Lys Val Lys Ser Glu Gly Thr Asp Ser 
             900                905                910
Tyr Val Ser Gln Leu Thr Ala Glu Ala Glu Asp His Leu Gln Ser Pro 
         915                920                925
Asn Arg Asp Ser Leu Tyr Thr Ser Met Pro Asn Leu Arg Asp Ser Pro 
     930                935                940
Tyr Pro Glu Ser Ser Pro Asp Met Glu Glu Asp Leu Ser Pro Ser Arg 
 945                950                955                960
Arg Ser Glu Asn Glu Asp Ile Tyr Tyr Lys Ser Met Pro Asn Leu Gly 
                 965                970                975
Ala Gly His Gln Leu Gln Met Cys Tyr Gln Ile Ser Arg Gly Asn Ser 
             980                985                990
Asp Gly Tyr Ile Ile Pro Ile Asn Lys Glu Gly Cys Ile Pro Glu Gly 
         995                1000                1005
Asp Val Arg Glu Gly Gln Met Gln Leu Val Thr Ser Leu 
     1010                1015                1020



<210> 978
<211> 5602
<212> DNA
<213> Rattus norvegicus
<308> AF063102
<400> 978

gaaaatatt  aaagggatc  ataatggtg  cttctggtt  cagaatgcg  agtctctgg  60
ttatcatga  aatcagttt  tcaccgaat  ccgaaggtt  cagcagagc  gccttgcca  120
tcgggttag  tagacgaga  ctgtcctgt  aaggttatt  tatagacct  cgatgtccg  180
gcagtgacg  catcatgat  gagagcgca  actacggtc  gacggacga  aagatctgc  240
acgcagacc  ctttcagat  gagaacaca  actgctacc  ccctgatgc  ttcaaaatc  300
tgactcaaa  gtgcaacaa  cgaacacag  gtgtagtag  taccgggtc  gatgtattt  360
ctgatccat  tcccggaac  tacaaatac  ttgaagttc  atatgaatg  gtcccttac  420
tggagcaaa  agtytttgt  tgtcctgga  ccttgaaag  aattgtgga  tctccaagt  480
tctatgaag  tgagcaaaa  gcaggtgct  ggtgcaagg  cccccttca  gctgcagat  540
aaatttatt  tatgccctg  actccctac  gcaccgata  cttaataga  tatgcttct  600
tagaagatt  tcaaaacag  cgccagaca  caacataca  acttccaaa  cgagtggac  660
gtactggat  tgtggtgta  gacggggca  tcttcttca  caaagaaag  acgagaaac  720
ttgttaaat  tgacttgag  actagaatc  agagtgggg  ggccataat  aactacgcc  780
actaccatg  cacctcacc  tacagatgg  gggggaaga  tgacattga  ctggcagtg  840
atgaaaatg  cttgtgggt  atctacgcc  ccgagcaga  caacggaat  atcgtgatt  900
gccagctca  tccgtacac  ctccgattc  aagcaacct  ggagacgac  tatgacaag  960
gtgcggcgt  caatgcttt  atgatatgc  gggtcctct  cgtggtcag  tcagtgtac  1020
aagacaatg  aagcgaagc  ggcaagaac  tcatcgact  catttacaa  acaaggttg  1080
gccggggag  gcacgtgga  gttcccttc  ccaaccagt  ccagtacat  gctgcagtg  1140
attacaacc  aagagacaa  caactctac  tatggaaca  taactttat  ttacggtat  1200
ctctggagt  tggtccacc  gaccctgcc  aagtgccta  cacagctgt  acaataact  1260
cttcagctg  gctgttcaa  accacagtg  caaccacaa  cagtacttc  cagagaggc  1320
ccgtgagca  cacagtcgc  ggtcctcag  aaggaagcc  agggacaaa  ccacctcca  1380
cagtctcta  aaccaaaat  cctcctgta  caaatattt  tcccctgcc  gagagattc  1440
gcgaagcgt  agaaatgaa  gggataaag  ggcctcaga  acaaagggg  atgatggtt  1500
agcgaccgt  tcccaaggg  acaagagga  cggcctcgt  tctctgcat  gcttccaca  1560
gaacctgga  cccgaaggg  ccggatctt  gcaactgca  ctctcactg  gtgaatcag  1620
tggcccaga  gatcagaag  ggagagaat  ctgcaagtc  ggccaacga  ctggctaag  1680
acaccaagg  gacggtgtt  gctggggat  tgagctcct  tgtgaggct  atggaacag  1740
tggtggaca  cctggatgc  cagctgcag  agctgaaac  gagcgagaa  gactcggcc  1800
ggaggagtt  taacaagct  caaaaacga  agaagacat  cagggctta  cttaaggcc  1860
ttgtggaca  agtagataa  cttctgaga  ccgagactt  ggactgctg  aaacacatg  1920
attcctcag  gcaggcgca  acagccacc  tgctgttgg  caccttgga  gaaggagca  1980
ttgtcctgg  agacaacct  ttggaacca  cccgggtct  aatgccaac  gataatatt  2040
ttctagaag  cgctgtcct  agcacggaa  gacaggtcc  agacttcac  ttccatctc  2100
gcttcaagg  ggccttcag  tccatccag  tctcagcca  caccgtcaa  caaaacagc  2160
gaaacgggc  ggcaaaggt  gtattcatc  tttaccgga  tctgggacc  ttcctgagc  2220
ccgaaaatg  gaccgtcaa  ctgggcgca  acctcctgg  tcggaacag  accatcgca  2280
tgaactcgc  cgtcctttc  gtctccatc  ataaggagt  cagccgtgt  tacttgaca  2340
acccggtgc  tttttcaat  ccacacatt  attctgaca  ttatttcaa  gcaaactgc  2400
ccttctgga  ctactcaga  agaaccatg  tgggatatt  gtctaccca  ggctgcaag  2460
tggttgaca  taataaaac  cgcacgacg  gtgcatgca  ccacctaac  aattttgct  2520
ttctcatgg  ccacaggga  attgtgtac  aagatggcg  ccacaaatt  ctgctgaca  2580
tcatcacct  ggtgggcat  gttgtctcc  tcgtctgcc  ggctatctg  atcttcacc  2640
tctgcttct  ccgaggcct  caaagcgac  gcaacacga  ccacaagaa  ctgtgtatc  2700
acctcttca  cgctgagtt  attttccta  taggcattg  taaaacaca  tacacgatt  2760
cgtgccccg  gtttgcagg  ctcctgcac  ttttcttcc  ggctgcttt  tcctggatg  2820
gcctagaag  tgtgcagct  tacctcatg  tggttgaag  tttcgagag  gaatactca  2880
ggaagaagt  ttactatgt  gccgggtac  tcttccctg  cacagtggt  ggtgtttca  2940
ctgctatcg  ctccaagag  tacgggaca  tagaggctt  ctggcttca  gttgataac  3000
atttcatat  gagtttcat  gggcctgtt  ctttcatca  tctgctaaa  attattttc  3060
tggtgatca  gctgtgcaa  atggtgaaa  attcaaaca  tttgaaacc  gattctagc  3120
ggttggaaa  cattaataa  taccgtgtt  gtgatggat  ctataatac  gacttacct  3180
gctatgaag  taataagcc  tttatcaag  cttgggtgc  cggtgcgtt  gccctgctg  3240
gtctcctgg  cctaacctg  tcctttggg  tgctttttg  taacgagga  accgttgtc  3300
tggcttatc  cttcaccgc  tttaatgct  tccagggac  gtttatttt  atcttccac  3360
gtgctcttc  aaagaaagt  cggaaagag  atgccaagt  cttcagaca  tggtactgc  3420
gtggcggcc  cccgaccga  agcccgcac  gctctgtaa  ggcgtccac  tcccgcacc  3480
gtgctcgct  ctcctctgg  acacagagc  gtataagaa  gatgtggaa  gacaccgtg  3540
ggaagcagt  tgaatcgtc  tttatctca  gtgacatca  tagcacttc  acccttaat  3600
aaggaatga  tggcaatta  ctactaaca  accctcttc  tcgacccca  ggcactaac  3660
acccctata  cacattgct  gctgaaaca  ttgtatgta  tgccccttc  gcgcccgtg  3720
ttaactcac  aggacattc  ctgaacaat  cccgggaca  cagcgccat  gatactcta  3780
cgctaaatg  taacttcaa  aacagctac  ccctgcgca  ggccgacta  cacgacggc  3840
tgcaggttg  ggactgtgg  ctaagtctg  acgacaccg  gtttgagaa  atgatcatt  3900
cagagttag  gcacaacaa  ctccggggt  gcaacaaaa  ccacaactt  gagctcaag  3960
tcccagtta  acccgtgat  ggcggcagc  gcagcgaag  tgacgcgat  gtggccgac  4020
cctcatctt  gatgcacgg  gataaccca  ggctggaat  ccgccacaa  gagctggag  4080
caccgctca  ccctcagcg  actcactcg  ttctgtacc  accccagaa  aaagtgaaa  4140
ccgaggcaa  cgacagcta  gtctcccag  tgacggccg  ggccgacga  cacctccag  4200
cccccaaca  agactctct  tacacgagc  tgcccaacc  aagagactc  ccctacccg  4260
agagcagcc  ggacatggc  gaggacctg  ctccctcca  gaggagcga  aacgaggac  4320
tttactaca  aagtatgcc  aatcttggg  ctggccgcc  gctccagat  tgctaccag  4380
tcagcagag  caatagcga  ggctacatc  tccccatta  caaagaagg  tgcatccca  4440
agggggacg  cagggaagg  cagatgcag  tggtaacaa  tctttaata  tacagctaa  4500
gaattccta  ggccacatg  aagtattaa  tgctaaaga  tgtgccagc  ggccctgca  4560
ctctcccca  ctcggccag  agaaccggc  ctgctggcc  gcggttctc  actgtagga  4620
aaaaaaatg  actgaacct  gcggttctg  gaattttta  aaaacatgc  aaaactttg  4680
atatacaca  agtatacta  attgaatta  ttgttacaa  gaaaaaaga  atgccaacc  4740
ggtatttta  gtttctgct  ctgtgtaga  agattgtaa  acaaacagg  gaccctccc  4800
gccatgatc  cgcggcagt  ggtgaactg  gtctgtaaa  agaacccta  cgttttggg  4860
tttttttgt  tgtttgttt  tttttgttt  tgttttgta  gcctgcatt  tattatata  4920
aagacgtag  ctttaagat  ctgtgggac  aattgactg  atcttactt  tcctgacaa  4980
acttggaaa  gcaggagag  gattctgca  ccgtttgca  ttccctgca  accttttac  5040
ttaaggcag  caccgaaac  atgtttaac  agtagcaat  aagccacag  ccttatctc  5100
tgtttcctc  actgtacaa  gaactgttc  catgaagaa  aaaaaagtt  atggctaaa  5160
aaaattata  tttgttcta  tgctagggt  aaaataaat  catttgtgt  caactgaga  5220
atcattaaa  taattttaa  aagagtttg  agaaaatat  gtgtcaagc  cttggttgc  5280
caaaatagg  gatgtctct  ctcccaccc  ccatggtga  tttgtgccc  tctttgttg  5340
ttcccactg  agacggtgt  tgctctgac  gcttagccc  ctttcttac  cttaaattt  5400
ttattgcca  aagagtgtg  tttatgggg  gaaaactct  tgaagtcct  ccatgcctt  5460
cacaaatgt  gggaaatct  gaggtcttg  gtcaaccct  tgtttattc  ggaacagag  5520
gcgaagggg  cactgggca  ttctcacaa  ctttctagt  aacaaaagg  gcctattct  5580
ttataaaaa  aaaaaaaaa  aa  5602



<210> 979
<211> 1488
<212> PRT
<213> Rattus norvegicus
<308> AF063102
<400> 979

Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Met Ile 
  1               5                  10                  15
Ile Ser Phe Ser Pro Asn Thr Glu Gly Phe Ser Arg Ala Ala Leu Pro 
             20                  25                  30
Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp 
         35                  40                  45
Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr 
     50                  55                  60
Gly Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu 
 65                  70                  75                  80
Asn Thr Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Thr Gln Arg 
                 85                  90                  95
Cys Asn Asn Arg Thr Gln Cys Val Val Val Thr Gly Ser Asp Val Phe 
             100                105                110
Pro Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu 
         115                120                125
Cys Val Pro Tyr Met Glu Gln Lys Val Phe Val Cys Pro Gly Thr Leu 
     130                135                140
Lys Ala Ile Val Asp Ser Pro Ser Ile Tyr Glu Ala Glu Gln Lys Ala 
 145                150                155                160
Gly Ala Trp Cys Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe 
                 165                170                175
Met Pro Trp Thr Pro Tyr Arg Thr Asp Thr Leu Ile Glu Tyr Ala Ser 
             180                185                190
Leu Glu Asp Phe Gln Asn Ser Arg Gln Thr Thr Thr Tyr Lys Leu Pro 
         195                200                205
Asn Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe 
     210                215                220
Phe Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr 
 225                230                235                240
Arg Ile Lys Ser Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp 
                 245                250                255
Thr Ser Pro Tyr Arg Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val 
             260                265                270
Asp Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly 
         275                280                285
Met Ile Val Ile Ser Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Ala 
     290                295                300
Thr Trp Glu Thr Thr Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met 
 305                310                315                320
Ile Cys Gly Val Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu 
                 325                330                335
Ser Glu Ala Gly Lys Asn Val Ile Asp Tyr Ile Tyr Asn Thr Arg Leu 
             340                345                350
Ser Arg Gly Glu His Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr 
         355                360                365
Ile Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp 
     370                375                380
Asn Asn Asn Phe Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp 
 385                390                395                400
Pro Ala Gln Val Pro Thr Thr Ala Val Thr Ile Thr Ser Ser Ala Glu 
                 405                410                415
Leu Phe Lys Thr Thr Val Ser Thr Thr Ser Ser Thr Ser Gln Arg Gly 
             420                425                430
Pro Val Ser Ser Thr Val Ala Gly Pro Gln Glu Gly Ser Arg Gly Thr 
         435                440                445
Lys Pro Pro Pro Ala Val Ser Thr Thr Lys Ile Pro Pro Val Thr Asn 
     450                455                460
Ile Phe Pro Leu Pro Glu Arg Phe Cys Glu Ala Leu Glu Met Lys Gly 
 465                470                475                480
Ile Lys Trp Pro Gln Thr Gln Arg Gly Met Met Val Glu Arg Pro Cys 
                 485                490                495
Pro Lys Gly Thr Arg Gly Thr Ala Ser Tyr Leu Cys Met Ala Ser Thr 
             500                505                510
Gly Thr Trp Asn Pro Lys Gly Pro Asp Leu Ser Asn Cys Thr Ser His 
         515                520                525
Trp Val Asn Gln Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala 
     530                535                540
Ser Leu Ala Asn Glu Leu Ala Lys His Thr Lys Gly Thr Val Phe Ala 
 545                550                555                560
Gly Asp Val Ser Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile 
                 565                570                575
Leu Asp Ala Gln Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala 
             580                585                590
Gly Arg Ser Tyr Asn Lys Leu Gln Lys Arg Glu Lys Thr Cys Arg Ala 
         595                600                605
Tyr Leu Lys Ala Ile Val Asp Thr Val Asp Asn Leu Leu Arg Ala Glu 
     610                615                620
Thr Leu Asp Cys Trp Lys His Met Asn Ser Ser Glu Gln Ala His Thr 
 625                630                635                640
Ala Thr Met Leu Leu Asp Thr Leu Glu Glu Gly Ala Phe Val Leu Ala 
                 645                650                655
Asp Asn Leu Leu Glu Pro Thr Arg Val Ser Met Pro Thr Asp Asn Ile 
             660                665                670
Val Leu Glu Val Ala Val Leu Ser Thr Glu Gly Gln Val Gln Asp Phe 
         675                680                685
Thr Phe His Leu Gly Phe Lys Gly Ala Phe Ser Ser Ile Gln Leu Ser 
     690                695                700
Ala Asn Thr Val Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Val Val 
 705                710                715                720
Phe Ile Ile Tyr Arg Ser Leu Gly Pro Phe Leu Ser Thr Glu Asn Ala 
                 725                730                735
Thr Val Lys Leu Gly Ala Asp Leu Leu Gly Arg Asn Ser Thr Ile Ala 
             740                745                750
Val Asn Ser His Val Leu Ser Val Ser Ile Asn Lys Glu Ser Ser Arg 
         755                760                765
Val Tyr Leu Thr Asp Pro Val Leu Phe Ser Met Pro His Ile Asp Ser 
     770                775                780
Asp Asn Tyr Phe Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg 
 785                790                795                800
Thr Met Met Gly Tyr Trp Ser Thr Gln Gly Cys Lys Leu Val Asp Thr 
                 805                810                815
Asn Lys Thr Arg Thr Thr Cys Ala Cys Ser His Leu Thr Asn Phe Ala 
             820                825                830
Ile Leu Met Ala His Arg Glu Ile Val Tyr Lys Asp Gly Val His Lys 
         835                840                845
Leu Leu Leu Thr Val Ile Thr Trp Val Gly Ile Val Val Ser Leu Val 
     850                855                860
Cys Leu Ala Ile Cys Ile Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln 
 865                870                875                880
Ser Asp Arg Asn Thr Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile 
                 885                890                895
Ala Glu Phe Ile Phe Leu Ile Gly Ile Asp Lys Thr Gln Tyr Thr Ile 
             900                905                910
Ala Cys Pro Val Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala 
         915                920                925
Phe Ser Trp Met Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val 
     930                935                940
Glu Val Phe Glu Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala 
 945                950                955                960
Gly Tyr Leu Phe Pro Ala Thr Val Val Gly Val Ser Ala Ala Ile Asp 
                 965                970                975
Ser Lys Ser Tyr Gly Thr Leu Glu Ala Cys Trp Leu His Val Asp Asn 
             980                985                990
Tyr Phe Ile Trp Ser Phe Ile Gly Pro Val Thr Phe Ile Ile Leu Leu 
         995                1000                1005
Asn Ile Ile Phe Leu Val Ile Thr Leu Cys Lys Met Val Lys His Ser 
     1010                1015                1020
Asn Thr Leu Lys Pro Asp Ser Ser Arg Leu Glu Asn Ile Asn Asn Tyr 
 1025                1030                1035                1040
Arg Val Cys Asp Gly Tyr Tyr Asn Thr Asp Leu Pro Gly Tyr Glu Asp 
                 1045                1050                1055
Asn Lys Pro Phe Ile Lys Ser Trp Val Leu Gly Ala Phe Ala Leu Leu 
             1060                1065                1070
Cys Leu Leu Gly Leu Thr Trp Ser Phe Gly Leu Leu Phe Val Asn Glu 
         1075                1080                1085
Glu Thr Val Val Met Ala Tyr Leu Phe Thr Ala Phe Asn Ala Phe Gln 
     1090                1095                1100
Gly Leu Phe Ile Phe Ile Phe His Cys Ala Leu Gln Lys Lys Val Arg 
 1105                1110                1115                1120
Lys Glu Tyr Ala Lys Cys Phe Arg His Trp Tyr Cys Cys Gly Gly Leu 
                 1125                1130                1135
Pro Thr Glu Ser Pro His Ser Ser Val Lys Ala Ser Thr Ser Arg Thr 
             1140                1145                1150
Ser Ala Arg Tyr Ser Ser Gly Thr Gln Ser Arg Ile Arg Arg Met Trp 
         1155                1160                1165
Asn Asp Thr Val Arg Lys Gln Ser Glu Ser Ser Phe Ile Ser Gly Asp 
     1170                1175                1180
Ile Asn Ser Thr Ser Thr Leu Asn Gln Gly Met Thr Gly Asn Tyr Leu 
 1185                1190                1195                1200
Leu Thr Asn Pro Leu Leu Arg Pro His Gly Thr Asn Asn Pro Tyr Asn 
                 1205                1210                1215
Thr Leu Leu Ala Glu Thr Val Val Cys Asn Ala Pro Ser Ala Pro Val 
             1220                1225                1230
Phe Asn Ser Pro Gly His Ser Leu Asn Asn Thr Arg Asp Thr Ser Ala 
         1235                1240                1245
Met Asp Thr Leu Pro Leu Asn Gly Asn Phe Asn Asn Ser Tyr Ser Leu 
     1250                1255                1260
Arg Lys Ala Asp Tyr His Asp Gly Val Gln Val Val Asp Cys Gly Leu 
 1265                1270                1275                1280
Ser Leu Asn Asp Thr Ala Phe Glu Lys Met Ile Ile Ser Glu Leu Val 
                 1285                1290                1295
His Asn Asn Leu Arg Gly Ser Asn Lys Thr His Asn Leu Glu Leu Lys 
             1300                1305                1310
Leu Pro Val Lys Pro Val Ile Gly Gly Ser Ser Ser Glu Asp Asp Ala 
         1315                1320                1325
Ile Val Ala Asp Ala Ser Ser Leu Met His Gly Asp Asn Pro Gly Leu 
     1330                1335                1340
Glu Phe Arg His Lys Glu Leu Glu Ala Pro Leu Ile Pro Gln Arg Thr 
 1345                1350                1355                1360
His Ser Leu Leu Tyr Gln Pro Gln Lys Lys Val Lys Pro Glu Ala Thr 
                 1365                1370                1375
Asp Ser Tyr Val Ser Gln Leu Thr Ala Glu Ala Asp Glu His Leu Gln 
             1380                1385                1390
Ser Pro Asn Arg Asp Ser Leu Tyr Thr Ser Met Pro Asn Leu Arg Asp 
         1395                1400                1405
Ser Pro Tyr Pro Glu Ser Ser Pro Asp Met Ala Glu Asp Leu Ser Pro 
     1410                1415                1420
Ser Arg Arg Ser Glu Asn Glu Asp Ile Tyr Tyr Lys Ser Met Pro Asn 
 1425                1430                1435                1440
Leu Gly Ala Gly Arg Gln Leu Gln Met Cys Tyr Gln Ile Ser Arg Gly 
                 1445                1450                1455
Asn Ser Asp Gly Tyr Ile Ile Pro Ile Asn Lys Glu Gly Cys Ile Pro 
             1460                1465                1470
Glu Gly Asp Val Arg Glu Gly Gln Met Gln Leu Val Thr Ser Leu Ter 
         1475                1480                1485



<210> 980
<211> 172
<212> DNA
<213> Homo sapiens
<308> AW238191
<400> 980

gcgtcgaca  acatgcaaa  actttgtat  tacacagag  atactaaat  gaattattt  60
ttacaaaga  aaaagaaat  ccaaccagg  attttacgt  tctgctgct  tgtagagag  120
ttgtaaaac  aacaagaga  cctccctcc  gtcgacgcg  ccgcggtcg  cg  172



<210> 981
<211> 1021
<212> PRT
<213> Homo sapiens
<308> BAA34506
<400> 981

Glu Gly Ser Lys Gly Thr Lys Pro Pro Pro Ala Val Ser Thr Thr Lys 
  1               5                  10                  15
Ile Pro Pro Ile Thr Asn Ile Phe Pro Leu Pro Glu Arg Phe Cys Glu 
             20                  25                  30
Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro Gln Thr Gln Arg Gly Met 
         35                  40                  45
Met Val Glu Arg Pro Cys Pro Lys Gly Thr Arg Gly Thr Ala Ser Tyr 
     50                  55                  60
Leu Cys Met Ile Ser Thr Gly Thr Trp Asn Pro Lys Gly Pro Asp Leu 
 65                  70                  75                  80
Ser Asn Cys Thr Ser His Trp Val Asn Gln Leu Ala Gln Lys Ile Arg 
                 85                  90                  95
Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn Glu Leu Ala Lys His Thr 
             100                105                110
Lys Gly Pro Val Phe Ala Gly Asp Val Ser Ser Ser Val Arg Leu Met 
         115                120                125
Glu Gln Leu Val Asp Ile Leu Asp Ala Gln Leu Gln Glu Leu Lys Pro 
     130                135                140
Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr Asn Lys Leu Gln Lys Arg 
 145                150                155                160
Glu Lys Thr Cys Arg Ala Tyr Leu Lys Ala Ile Val Asp Thr Val Asp 
                 165                170                175
Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys His Met Asn Ser 
             180                185                190
Ser Glu Gln Ala His Thr Ala Thr Met Leu Leu Asp Thr Leu Glu Glu 
         195                200                205
Gly Ala Phe Val Leu Ala Asp Asn Leu Leu Glu Pro Thr Arg Val Ser 
     210                215                220
Met Pro Thr Glu Asn Ile Val Leu Glu Val Ala Val Leu Ser Thr Glu 
 225                230                235                240
Gly Gln Ile Gln Asp Phe Lys Phe Pro Leu Gly Ile Lys Gly Ala Gly 
                 245                250                255
Ser Ser Ile Gln Leu Ser Ala Asn Thr Val Lys Gln Asn Ser Arg Asn 
             260                265                270
Gly Leu Ala Lys Leu Val Phe Ile Ile Tyr Arg Ser Leu Gly Gln Phe 
         275                280                285
Leu Ser Thr Glu Asn Ala Thr Ile Lys Leu Gly Ala Asp Phe Ile Gly 
     290                295                300
Arg Asn Ser Thr Ile Ala Val Asn Ser His Val Ile Ser Val Ser Ile 
 305                310                315                320
Asn Lys Glu Ser Ser Arg Val Tyr Leu Thr Asp Pro Val Leu Phe Thr 
                 325                330                335
Leu Pro His Ile Asp Pro Asp Asn Tyr Phe Asn Ala Asn Cys Ser Phe 
             340                345                350
Trp Asn Tyr Ser Glu Arg Thr Met Met Gly Tyr Trp Ser Thr Gln Gly 
         355                360                365
Cys Lys Leu Val Asp Thr Asn Lys Thr Arg Thr Thr Cys Ala Cys Ser 
     370                375                380
His Leu Thr Asn Phe Ala Ile Leu Met Ala His Arg Glu Ile Ala Tyr 
 385                390                395                400
Lys Asp Gly Val His Glu Leu Leu Leu Thr Val Ile Thr Trp Val Gly 
                 405                410                415
Ile Val Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Phe Thr Phe Cys 
             420                425                430
Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Thr Ile His Lys Asn Leu 
         435                440                445
Cys Ile Asn Leu Phe Ile Ala Glu Phe Ile Phe Leu Ile Gly Ile Asp 
     450                455                460
Lys Thr Lys Tyr Ala Ile Ala Cys Pro Ile Phe Ala Gly Leu Leu His 
 465                470                475                480
Phe Phe Phe Leu Ala Ala Phe Ala Trp Met Cys Leu Glu Gly Val Gln 
                 485                490                495
Leu Tyr Leu Met Leu Val Glu Val Phe Glu Ser Glu Tyr Ser Arg Lys 
             500                505                510
Lys Tyr Tyr Tyr Val Ala Gly Tyr Leu Phe Pro Ala Thr Val Val Gly 
         515                520                525
Val Ser Ala Ala Ile Asp Tyr Lys Ser Tyr Gly Thr Glu Lys Ala Cys 
     530                535                540
Trp Leu His Val Asp Asn Tyr Phe Ile Trp Ser Phe Ile Gly Pro Val 
 545                550                555                560
Thr Phe Ile Ile Leu Leu Asn Ile Ile Phe Leu Val Ile Thr Leu Cys 
                 565                570                575
Lys Met Val Lys His Ser Asn Thr Leu Lys Pro Asp Ser Ser Arg Leu 
             580                585                590
Glu Asn Ile Lys Ser Trp Val Leu Gly Ala Phe Ala Leu Leu Cys Leu 
         595                600                605
Leu Gly Leu Thr Trp Ser Phe Gly Leu Leu Phe Ile Asn Glu Glu Thr 
     610                615                620
Ile Val Met Ala Tyr Leu Phe Thr Ile Phe Asn Ala Phe Gln Gly Val 
 625                630                635                640
Phe Ile Phe Ile Phe His Cys Ala Leu Gln Lys Lys Val Arg Lys Glu 
                 645                650                655
Tyr Gly Lys Cys Phe Arg His Ser Tyr Cys Cys Gly Gly Leu Pro Thr 
             660                665                670
Glu Ser Pro His Ser Ser Val Lys Ala Ser Thr Thr Arg Thr Ser Ala 
         675                680                685
Arg Tyr Ser Ser Gly Thr Gln Ser Arg Ile Arg Arg Met Trp Asn Asp 
     690                695                700
Thr Val Arg Lys Gln Ser Glu Ser Ser Phe Ile Ser Gly Asp Ile Asn 
 705                710                715                720
Ser Thr Ser Thr Leu Asn Gln Gly Met Thr Gly Asn Tyr Leu Leu Thr 
                 725                730                735
Asn Pro Leu Leu Arg Pro His Gly Thr Asn Asn Pro Tyr Asn Thr Leu 
             740                745                750
Leu Ala Glu Thr Val Val Cys Asn Ala Pro Ser Ala Pro Val Phe Asn 
         755                760                765
Ser Pro Gly His Ser Leu Asn Asn Ala Arg Asp Thr Ser Ala Met Asp 
     770                775                780
Thr Leu Pro Leu Asn Gly Asn Phe Asn Asn Ser Tyr Ser Leu His Lys 
 785                790                795                800
Gly Asp Tyr Asn Asp Ser Val Gln Val Val Asp Cys Gly Leu Ser Leu 
                 805                810                815
Asn Asp Thr Ala Phe Glu Lys Met Ile Ile Ser Glu Leu Val His Asn 
             820                825                830
Asn Leu Arg Gly Ser Ser Lys Thr His Asn Leu Glu Leu Thr Leu Pro 
         835                840                845
Val Lys Pro Val Ile Gly Gly Ser Ser Ser Glu Asp Asp Ala Ile Val 
     850                855                860
Ala Asp Ala Ser Ser Leu Met His Ser Asp Asn Pro Gly Leu Glu Leu 
 865                870                875                880
His His Lys Glu Leu Glu Ala Pro Leu Ile Pro Gln Arg Thr His Ser 
                 885                890                895
Leu Leu Tyr Gln Pro Gln Lys Lys Val Lys Ser Glu Gly Thr Asp Ser 
             900                905                910
Tyr Val Ser Gln Leu Thr Ala Glu Ala Glu Asp His Leu Gln Ser Pro 
         915                920                925
Asn Arg Asp Ser Leu Tyr Thr Ser Met Pro Asn Leu Arg Asp Ser Pro 
     930                935                940
Tyr Pro Glu Ser Ser Pro Asp Met Glu Glu Asp Leu Ser Pro Ser Arg 
 945                950                955                960
Arg Ser Glu Asn Glu Asp Ile Tyr Tyr Lys Ser Met Pro Asn Leu Gly 
                 965                970                975
Ala Gly His Gln Leu Gln Met Cys Tyr Gln Ile Ser Arg Gly Asn Ser 
             980                985                990
Asp Gly Tyr Ile Ile Pro Ile Asn Lys Glu Gly Cys Ile Pro Glu Gly 
         995                1000                1005
Asp Val Arg Glu Gly Gln Met Gln Leu Val Thr Ser Leu 
     1010                1015                1020



<210> 982
<211> 5413
<212> DNA
<213> Rattus norvegicus
<308> AF063103
<400> 982

aatcattga  attggaata  agaagagga  ccagaagta  actgatttg  cttcacctc  60
gaacagcca  tcttgaggc  ttctcctcc  agaacacag  catgtgtcc  cctcagctg  120
tcatcctca  gatgctttt  gcacctgta  ttcatggtg  caagcacaa  gagagacat  180
cagccctcg  tgctccact  cgacatgct  agcacagcc  aggaggccc  ctccctccc  240
gacatcttc  tcagcagcc  gctgcagag  gctctacag  tcatcgagg  caagggcca  300
gtggaactg  cagaggagt  cgcggaccc  gtgccccag  agcacagat  gcagcccaa  360
ctttcagcc  tgccccaat  cccatggca  tggtccgca  agagctctc  tgtgagagc  420
accccattg  gctacgctg  ccaggcaca  acgtcatca  gatcgaaag  gccaactac  480
ggaggacag  tgacaagat  tgtgactcg  accctgctc  gatggagaa  attcggtgt  540
atctgccag  tgcctataa  attatgtct  aaagatgca  taacagaac  cagtgtgca  600
tggtggcag  tcctgatgt  tttccagac  catgtccgg  aacatataa  taccttgaa  660
tgcagtatg  atgtgtccc  tacaaagtg  aacaaaaag  ttttctttg  cccggactg  720
tcaaaggag  gtaccagag  gaacacttg  ttgaatctg  ccaccaatc  ggggcatgg  780
gcaaagacc  tctacaggc  tctgacaag  tttactata  gccctggac  ccctacaga  840
ccgataccc  gacagagta  tcatccaaa  atgacttca  tgctggaag  ccgacaact  900
catacaagc  ccctcacag  gtggatggt  ctggatttg  agtatatga  ggtgccctg  960
tcttcaaca  ggagcgtac  aggaacata  taaagtttg  tttgaggac  aggataaag  1020
gtggagagg  aatcatagc  aatgctaac  accatgata  ctccccata  cgatggggt  1080
gcaagtccg  catagactt  gcagtggat  aaaacggat  atgggtaat  tatgcaaca  1140
aacagaaca  tggcaaaat  gttattagc  agttgaacc  ttacaccct  cggattgag  1200
ggacatggg  cactgccta  gataaaagg  ctgcttcca  tgcatttat  atttgtggg  1260
ttctgtatg  ggtcaagtc  gtatatgag  atgacgaca  tgaggccac  ggtaataag  1320
ttgactaca  ttacaatac  gaccaaagc  aggatagcc  ggtggatgt  ccctttccc  1380
actcatacc  gtacatagc  gccgtggac  acaatccca  ggacaatct  ctgtacgtg  1440
ggaacaact  ccatgttgt  aaatactcc  tggacttcg  gcctctgga  agcagatca  1500
ggccagtgc  tcatggaca  gtttcctac  tctctccac  gattcacct  gactctgac  1560
tggaaaggc  ccctgtcag  gggatttct  ccacaggac  cctgggtat  ggaagcacg  1620
ccaccagca  caccctccg  actaccacc  ggaacctag  gaggagtac  acgccatcc  1680
tgcctggca  aagaaaccg  agtaccagt  cgccgtccc  agcgattga  gtgctggat  1740
ttaccacac  cctgccatc  gcagcctcc  aaatcccag  gatggaaga  agctgcgag  1800
ctgtggaag  ccgagagat  atgtggttt  agacccgac  ggggcaagt  gcaaagcag  1860
catgcccag  aggaaccat  ggtgtatca  cttacctgt  tcttgctcc  gatggaata  1920
gggatcccc  aggaccaga  ctcagcaac  gctcttctc  ttgggtcaa  cacataaca  1980
agaagctga  atctggaga  acagctgcc  atattgcca  agagctagc  gaacagacc  2040
gaaatcatt  gaacgccgg  gatatcacc  actcagttc  tgccatgga  caactggtt  2100
gcctcctgg  cgtacagct  aggaatttg  caccagggg  gaaggacag  gctgcccga  2160
gcttgaaca  gcttcagaa  agagagcgc  cttgcagag  ctatgtcca  gcgatggtg  2220
agacagtta  caatctcct  cagccacaa  ctctgaatg  gtggaggga  ctgacgaca  2280
gtgatcaac  acgcgcagc  accatgttg  tcgacactg  ggaggagag  gctttcgtg  2340
tagccgata  ccttttgaa  accgacatt  tcagggaga  tacagacaa  attcagttg  2400
aggttgcaa  gctgagcac  gaaggaaac  tagaagatc  aaaatttcc  gaaaacacg  2460
gccacggaa  cactataca  ctttccgca  acacgttaa  gcaaaatgg  cggaatgga  2520
agattagag  ggcctttgt  ctgtataac  acctgggtc  ttatttatc  acggagaat  2580
ccagtatga  gttgggcac  gaagctatg  ccacaaatc  ctcagttat  gtcaattcc  2640
ctgttatta  agcagcaat  aataaggaa  tcagtaata  agtgtattt  gctgatcct  2700
tggtattta  tgttaaaca  atcaagcag  cagaggaaa  tttcaaccc  aactgttca  2760
tttggagct  ttccaagcg  acaatgaca  gttattggt  aacacaagg  tgtcgactc  2820
tgacaacga  caagacaca  actacgtgc  cctgtaacc  cctcaccaa  ttcgcagta  2880
taatggcac  tgtggaagt  aagcacagc  atgccgtcc  cgatcttct  ctggatgtg  2940
tcacgtggg  cggaatcct  ttgtctctt  tttgtctcc  gatctgcat  ttcacattc  3000
gcttcttcc  tgggcttca  agcgaccgt  acaccattc  caagaacct  tgcatcagc  3060
tgtttgtgg  agaactgct  ttcctgatt  ggatcaaca  aaccgacca  ccgattgcc  3120
gtgcagtgt  tgcggctct  ttgcatttc  tcttcttgg  ggccttcac  tggatgttt  3180
tagaagggg  acagctgta  atcatgctg  tggaggtct  tgagagtga  cattcccgt  3240
ggaagtact  ctatctggt  ggctacggg  tgcccgcac  catcgtggc  gtttctgct  3300
cagtcgact  caggagcta  ggaacagac  aagtatgtt  gcttcgcct  gacacctac  3360
tcatttgga  ttttatagg  ccagcgacc  tgataatta  gctgaatgt  atcttcctc  3420
ggattgctt  atacaaaat  tttcaccat  ctgccatac  gaaacctga  tcaggctgt  3480
ttgataata  caactatga  gataacaga  ccttcatca  gtcatgggt  ataggtgca  3540
tagcgctgc  ctgcctatt  ggattgacc  gggcctttg  actcatgta  attaatgaa  3600
gcacagtca  catggcgta  ctcttcacc  ttttcaatt  tctacaggg  atgtttata  3660
tcattttcc  ctgtgtcct  cagaagaag  tacggaaag  gtatgggaa  tgcctacgg  3720
cgcattgct  tagtgggaa  agcacggag  gttcgattg  ctcagggaa  acatctggt  3780
ctcgaactc  aggacggta  tccacaggc  cacagagcc  gattcggag  atgtggaat  3840
acaccgtcc  aaagcagtc  gagtcatcc  tcatcactg  agacataaa  agctcagcg  3900
cgctcaaca  aggatccta  cttccctgc  ttcaggcgt  tgtaacata  ttagagggg  3960
ttctgaaca  tgccaggga  acaagtgtc  tggatactc  accactgaa  ggtaaccat  4020
gcaacagtt  cagcattgc  ggcggcgaa  acctgagca  ctgtgtgca  attatagac  4080
gtggctata  ccacaacga  accgcccta  aaaaaaaga  cctaaagga  ctcacttcc  4140
actatatcc  ttcatacct  aacaaccac  agcgctcca  cgaacagaa  cggaacatg  4200
tgaacaaac  ggtggacaa  ttaggcagt  ggagtgaag  tgacgccat  gtcctggat  4260
acgcagcgt  ctttaacca  gaggagagt  tgggcctgg  actcattca  gaggaatcg  4320
atgctccct  gctgccccc  agggtttac  ccaccgata  ccaccagcc  caccattac  4380
gcaggaggc  gctccccca  gaccacagc  agagcttct  ccctctgct  accgacgag  4440
acacagaag  cccgcagtc  ccgcacagg  actctctgt  caccagcat  ccggccctg  4500
ccggtgtgc  cgctgcaga  agtgtgacc  ccagcaccc  gaccgaagc  gcagcggcc  4560
agggtggtg  cgccgaaga  gtttactac  aaagcatgc  aaacctggg  tccagaaac  4620
atgtgcacc  gctgcacgc  tactaccag  tagggcgag  cagcagcga  ggattcata  4680
ttcctccca  taaagatgg  gcctctccg  aggggactt  caaaggacc  gcgcacttg  4740
tcactagtc  atagaaggt  acacgggga  gacaaccaa  gggacagct  acacccggt  4800
gcccattct  agtcgatat  agcagtggt  atcgtgtgt  acacgtgtg  gacatctga  4860
gctgatctc  aaagagaga  tctgacatt  ggttttttt  ttttttttt  aacttgaat  4920
tttaggtca  cgcagggga  aaagctccc  ctgtgcccc  gtctttccc  tctttcccc  4980
cagatggac  cttcattat  ttaatgaac  agataagat  aaaatggcg  tcattgtgg  5040
cctgttgag  taggttgtg  ttaacagct  tgatgctct  ttactagaa  cacgaggac  5100
tgatttttc  ttctttttt  tttttttaa  aaaaaagag  ccggaacta  tgtttggaa  5160
tagtaacaa  gctgcatct  gattggagt  ctgcccagc  gtagaagca  agcagaact  5220
tatcccata  cggtgcgcg  tcactcgca  cctgagttc  ccacagcga  catagctgt  5280
aaaagcaaa  gcaaaacaa  agaattaat  atctgacgg  ggggaattc  agaattata  5340
gctaaatgc  tattttatg  tttgctgta  taactgatg  taaaactaa  ggcagaaaa  5400
aaaaaaaaa  aaa  5413



<210> 983
<211> 1550
<212> PRT
<213> Rattus norvegicus
<308> AAC77816
<400> 983

Met Cys Pro Pro Gln Leu Phe Ile Leu Met Met Leu Leu Ala Pro Val 
  1               5                  10                  15
Val His Gly Gly Lys His Asn Glu Arg His Pro Ala Leu Ala Ala Pro 
             20                  25                  30
Leu Arg His Ala Glu His Ser Pro Gly Gly Pro Leu Pro Pro Arg His 
         35                  40                  45
Leu Leu Gln Gln Pro Ala Ala Glu Arg Ser Thr Ala His Arg Gly Gln 
     50                  55                  60
Gly Pro Arg Gly Thr Ala Arg Gly Val Arg Gly Pro Gly Ala Pro Gly 
 65                  70                  75                  80
Ala Gln Ile Ala Ala Gln Ala Phe Ser Arg Ala Pro Ile Pro Met Ala 
                 85                  90                  95
Val Val Arg Arg Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg 
             100                105                110
Cys Pro Gly Thr Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg 
         115                120                125
Thr Asp Asp Lys Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile 
     130                135                140
Arg Cys Tyr Leu Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn 
 145                150                155                160
Asn Arg Thr Gln Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp 
                 165                170                175
Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val 
             180                185                190
Pro Tyr Lys Val Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys 
         195                200                205
Gly Val Tyr Gln Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly 
     210                215                220
Ala Trp Cys Lys Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met 
 225                230                235                240
Pro Trp Thr Pro Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ser Ser Lys 
                 245                250                255
Asp Asp Phe Ile Ala Gly Arg Pro Thr Thr Thr Tyr Lys Leu Pro His 
             260                265                270
Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe 
         275                280                285
Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr Arg 
     290                295                300
Ile Lys Ser Gly Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Thr 
 305                310                315                320
Ser Pro Tyr Arg Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp 
                 325                330                335
Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly Lys 
             340                345                350
Ile Val Ile Ser Gln Leu Asn Pro Tyr Thr Leu Arg Ile Glu Gly Thr 
         355                360                365
Trp Asp Thr Ala Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile 
     370                375                380
Cys Gly Ile Leu Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn 
 385                390                395                400
Glu Ala Thr Gly Asn Lys Ile Asp Tyr Ile Tyr Asn Thr Asp Gln Ser 
                 405                410                415
Lys Asp Ser Leu Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile 
             420                425                430
Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn 
         435                440                445
Asn Tyr His Val Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser 
     450                455                460
Arg Ser Gly Pro Val His His Gly Gln Val Ser Tyr Ile Ser Pro Pro 
 465                470                475                480
Ile His Leu Asp Ser Asp Leu Glu Arg Pro Pro Val Arg Gly Ile Ser 
                 485                490                495
Thr Thr Gly Pro Leu Gly Met Gly Ser Thr Thr Thr Ser Thr Thr Leu 
             500                505                510
Arg Thr Thr Thr Trp Asn Leu Gly Arg Ser Thr Thr Pro Ser Leu Pro 
         515                520                525
Gly Arg Arg Asn Arg Ser Thr Ser Thr Pro Ser Pro Ala Ile Glu Val 
     530                535                540
Leu Asp Val Thr Thr His Leu Pro Ser Ala Ala Ser Gln Ile Pro Ala 
 545                550                555                560
Met Glu Glu Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe 
                 565                570                575
Lys Thr Arg Gln Gly Gln Val Ala Lys Gln Ser Cys Pro Ala Gly Thr 
             580                585                590
Ile Gly Val Ser Thr Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp 
         595                600                605
Pro Gln Gly Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His 
     610                615                620
Ile Thr Gln Lys Leu Lys Ser Gly Glu Thr Ala Ala Asn Ile Ala Arg 
 625                630                635                640
Glu Leu Ala Glu Gln Thr Arg Asn His Leu Asn Ala Gly Asp Ile Thr 
                 645                650                655
Tyr Ser Val Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln 
             660                665                670
Leu Arg Asn Leu Thr Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu 
         675                680                685
Asn Lys Leu Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala 
     690                695                700
Met Val Glu Thr Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala 
 705                710                715                720
Trp Arg Asp Leu Thr Thr Ser Asp Gln Leu Arg Ala Ala Thr Met Leu 
                 725                730                735
Leu Asp Thr Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu 
             740                745                750
Lys Thr Asp Ile Val Arg Glu Asn Thr Asp Asn Ile Gln Leu Glu Val 
         755                760                765
Ala Arg Leu Ser Thr Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu 
     770                775                780
Asn Thr Gly His Gly Ser Thr Ile Gln Leu Ser Ala Asn Thr Leu Lys 
 785                790                795                800
Gln Asn Gly Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn 
                 805                810                815
Asn Leu Gly Pro Tyr Leu Ser Thr Glu Asn Ala Ser Met Lys Leu Gly 
             820                825                830
Thr Glu Ala Met Ser Thr Asn His Ser Val Ile Val Asn Ser Pro Val 
         835                840                845
Ile Thr Ala Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala 
     850                855                860
Asp Pro Val Val Phe Thr Val Lys His Ile Lys Gln Ser Glu Glu Asn 
 865                870                875                880
Phe Asn Pro Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Thr Met Thr 
                 885                890                895
Gly Tyr Trp Ser Thr Gln Gly Cys Arg Leu Leu Thr Thr Asn Lys Thr 
             900                905                910
His Thr Thr Cys Ser Cys Asn His Leu Thr Asn Phe Ala Val Leu Met 
         915                920                925
Ala His Val Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu 
     930                935                940
Asp Val Ile Thr Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu 
 945                950                955                960
Ile Cys Ile Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg 
                 965                970                975
Asn Thr Ile His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu 
             980                985                990
Leu Phe Leu Ile Gly Ile Asn Arg Thr Asp Gln Pro Ile Ala Cys Ala 
         995                1000                1005
Val Phe Ala Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Thr Trp 
     1010                1015                1020
Met Phe Leu Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe 
 1025                1030                1035                1040
Glu Ser Glu His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly 
                 1045                1050                1055
Met Pro Ala Leu Ile Val Ala Val Ser Ala Ala Val Asp Tyr Arg Ser 
             1060                1065                1070
Tyr Gly Thr Asp Lys Val Cys Trp Leu Arg Leu Asp Thr Tyr Phe Ile 
         1075                1080                1085
Trp Ser Phe Ile Gly Pro Ala Thr Leu Ile Ile Met Leu Asn Val Ile 
     1090                1095                1100
Phe Leu Gly Ile Ala Leu Tyr Lys Met Phe His His Thr Ala Ile Leu 
 1105                1110                1115                1120
Lys Pro Glu Ser Gly Cys Leu Asp Asn Ile Asn Tyr Glu Asp Asn Arg 
                 1125                1130                1135
Pro Phe Ile Lys Ser Trp Val Ile Gly Ala Ile Ala Leu Leu Cys Leu 
             1140                1145                1150
Leu Gly Leu Thr Trp Ala Phe Gly Leu Met Tyr Ile Asn Glu Ser Thr 
         1155                1160                1165
Val Ile Met Ala Tyr Leu Phe Thr Ile Phe Asn Ser Leu Gln Gly Met 
     1170                1175                1180
Phe Ile Phe Ile Phe His Cys Val Leu Gln Lys Lys Val Arg Lys Glu 
 1185                1190                1195                1200
Tyr Gly Lys Cys Leu Arg Thr His Cys Cys Ser Gly Lys Ser Thr Glu 
                 1205                1210                1215
Ser Ser Ile Gly Ser Gly Lys Thr Ser Gly Ser Arg Thr Pro Gly Arg 
             1220                1225                1230
Tyr Ser Thr Gly Ser Gln Ser Arg Ile Arg Arg Met Trp Asn Asp Thr 
         1235                1240                1245
Val Arg Lys Gln Ser Glu Ser Ser Phe Ile Thr Gly Asp Ile Asn Ser 
     1250                1255                1260
Ser Ala Ser Leu Asn Arg Gly Ser Tyr Leu Pro Cys Ile Gln Ala Cys 
 1265                1270                1275                1280
Val Thr Tyr Leu Glu Gly Leu Leu Asn Asn Ala Arg Asp Thr Ser Val 
                 1285                1290                1295
Met Asp Thr Leu Pro Leu Asn Gly Asn His Gly Asn Ser Tyr Ser Ile 
             1300                1305                1310
Ala Gly Gly Glu Tyr Leu Ser Asn Cys Val Gln Ile Ile Asp Arg Gly 
         1315                1320                1325
Tyr Asn His Asn Glu Thr Ala Leu Glu Lys Lys Ile Leu Lys Glu Leu 
     1330                1335                1340
Thr Ser Asn Tyr Ile Pro Ser Tyr Leu Asn Asn His Glu Arg Ser Ser 
 1345                1350                1355                1360
Glu Gln Asn Arg Asn Met Met Asn Lys Leu Val Asp Asn Leu Gly Ser 
                 1365                1370                1375
Gly Ser Glu Asp Asp Ala Ile Val Leu Asp Asp Ala Ala Ser Phe Asn 
             1380                1385                1390
His Glu Glu Ser Leu Gly Leu Glu Leu Ile His Glu Glu Ser Asp Ala 
         1395                1400                1405
Pro Leu Leu Pro Pro Arg Val Tyr Ser Thr Asp Asn His Gln Pro His 
     1410                1415                1420
His Tyr Ser Arg Arg Arg Leu Pro Gln Asp His Ser Glu Ser Phe Phe 
 1425                1430                1435                1440
Pro Leu Leu Thr Asp Glu His Thr Glu Asp Pro Gln Ser Pro His Arg 
                 1445                1450                1455
Asp Ser Leu Tyr Thr Ser Met Pro Ala Leu Ala Gly Val Pro Ala Ala 
             1460                1465                1470
Asp Ser Val Thr Thr Ser Thr Gln Thr Glu Ala Ala Ala Ala Lys Gly 
         1475                1480                1485
Gly Asp Ala Glu Asp Val Tyr Tyr Lys Ser Met Pro Asn Leu Gly Ser 
     1490                1495                1500
Arg Asn His Val His Pro Leu His Ala Tyr Tyr Gln Leu Gly Arg Gly 
 1505                1510                1515                1520
Ser Ser Asp Gly Phe Ile Val Pro Pro Asn Lys Asp Gly Ala Ser Pro 
                 1525                1530                1535
Glu Gly Thr Ser Lys Gly Pro Ala His Leu Val Thr Ser Leu 
             1540                1545                1550



<210> 984
<211> 6533
<212> DNA
<213> Homo sapiens
<308> AF307080
<400> 984

gaaaaacac  agccgtgtt  tatgtggag  ccccggtgt  tgggtgtaa  tctcgttcc  60
tctgtgagg  gaggcagat  aagccattt  gtggttctg  tgagcatgg  cttggcagt  120
tttttggga  catcacact  tgccccttt  gttaacttg  tagcccggc  tgtcttttg  180
cccgggctc  atggctgga  tgtggaaac  gcacccgcc  tcaggttgt  gagcaactg  240
tgggacgat  tcagggacc  gcgtttacg  aagaaatgt  taatttggt  aattggagg  300
aaaaaacat  gatttttag  aattgaaga  caaattaag  tttcagatt  gggatattg  360
tgtttctgt  ttggagaaa  tattctttt  ctttttaat  tgaagaaaa  tcatcagtc  420
tggaataca  aagagaaac  agaaatata  gtattttgt  tcacatttg  acagtcatt  480
ttgaggaat  ctccatacc  gagtagaca  ccatgtggc  atcgcagct  ctaattttc  540
tgatgctct  agctccaat  attcatgct  tcagccgtg  cccaattcc  atggctgtg  600
tccgcagag  gctatcctg  gagagctat  ctatagagc  tcgctgtcc  ggaacagac  660
tcatcatga  agaaagtgc  aactatggc  ggactgatg  caaaatttg  gactctgac  720
ctgctcaga  ggagaatat  cgatgttat  tgccagatg  ctataagat  atgtctcaa  780
gatgcaata  cagaaccca  tgtgcagtg  tggcaggtc  tgatgtttt  ccagacccg  840
gtccaggaa  ctataaata  cttgaagtg  agtatgaat  tgtccctta  aaagtggaa  900
aaaaagttt  tctttgtcc  ggactacta  aaggagtat  ccagagtga  catttgttt  960
agtccgacc  ccaatctgg  gcgtggtgc  aagaccctc  gcaggcatc  gacaagatt  1020
attatatgc  ctggactcc  tacagaact  ataccctga  tgagtattc  tccaaggat  1080
acttcattg  tggaagacc  actacaacc  acaagctcc  tcatagggt  gatggcaca  1140
gatttgtag  gtatgatgg  gctttgttc  tcaacaaag  gcgcaccag  aacatagta  1200
agtttgatt  gcggactag  ataaagagt  gagaggcta  catagcaaa  gccaattac  1260
atgatacct  cccttaccg  tggggaggc  aatctgaca  agacctggc  gtagatgag  1320
atgggctat  ggtaatcta  gcaacagaa  aaaacaatg  taaaattgt  attagtcaa  1380
tgaaccctt  caccctacg  atcgaagga  catgggata  tgcatatga  aaaaggtca  1440
cttccaatg  ctttatgat  tgtggaatt  tgtatgtgg  caaatctgt  tatgaggat  1500
atgacaatg  ggctactgg  aataagatt  actacattt  caacactga  caaagcaag  1560
atagtttgg  ggatgtacc  tttcctaat  cataccagt  cattgcagc  gtggattac  1620
accccaggg  caacctact  tatgtatgg  ataactatc  cgtcgtgaa  tattctttg  1680
attttggac  tctggatag  agatcaggg  aggcacatc  tggacaagt  tcatacatt  1740
ctccgccaa  tcaccttga  tctgagcta  aaagaccct  tgttaaaga  atctctacc  1800
caggacctc  tggcatggg  agcactacc  ccagtacca  ccttcggac  acaactttg  1860
gcccaggaa  gagtaccac  ccgtcagtg  caggaagaa  aaaccggag  actagtacc  1920
catctccag  tgtcgaggt  cttgatgac  tgaccacac  ccttccatc  gcatcgtcc  1980
aaatcccag  tctcgaaga  agctgtgag  ctgtggaag  ccgagaaat  atgtggttt  2040
agactcgtc  aggacagat  gcaaagcag  catgccctg  aggaactat  ggtgtatca  2100
cttatctat  ccttgctcc  gatggaatt  gggatcccc  aggtccaga  ctcagcaac  2160
gttcttctc  ttgggtcaa  catataaca  agaagttga  atctggtga  acagctgcc  2220
acattgcta  agagctggc  gaacagaca  gaaatcact  gaatgctgg  gacatcacc  2280
actctgtcc  ggccatgga  cagctggta  gcctcctag  tgtacagct  cggaacttg  2340
ccccaggtg  aaaagatag  gctgcccgg  gtttgaaca  gcttcagaa  agagagcgc  2400
cttgcagag  ctatgtcca  gcaatggtc  agacagtta  caacctcct  cagccacaa  2460
ctttgaatg  atggagaga  ctgactacg  gtgatcagc  gcgtgcggc  accatgttg  2520
ttcatactg  ggaggaaag  gcttttgtg  tggctgata  ccttttgaa  actgacatt  2580
tcagggaga  tacagacaa  attaaattg  aagttgcaa  actgagcac  gaaggaaac  2640
tagaagacc  aaaatttcc  gaaaacatg  gccatggaa  cactatcca  ctgtctgca  2700
ataccttaa  gcaaaatgg  cgaaatgga  agatcagag  ggcctttgt  ctgtataac  2760
acttgggtc  ttatttatc  acggagaat  ccagtatga  gttgggaac  gaagctttg  2820
ccacaaatc  ttctgttat  gtcaattcc  ctgttatta  ggcagcaat  aacaaagag  2880
tcagtaaca  ggtttattt  gctgatcct  tggtattta  tgttaaaca  atcaagcag  2940
cagaggaaa  tttcaaccc  aactgttca  tttggagct  ctccaagcg  acaatgaca  3000
gttattggt  aacacaagg  tgtcggctc  tgacaacaa  taagacaca  actacatgc  3060
cttgtaacc  cctaacaaa  tttgcagta  tgatggcac  tgtggaagt  aagcacagt  3120
atgcggtcc  tgacctcct  ctggatgtg  tcacgtggg  tggaatttt  ctgtccctt  3180
tttgtctcc  gatttgcat  ttcacattt  gctttttcc  cgggctcca  agtgaccgt  3240
acaccatcc  caagaacct  tgcatcagt  tctttgtag  agagctgct  ttcctgatt  3300
ggatcaacc  aactgacca  ccaattgcc  gtgctgttt  cgctgccct  ttacatttc  3360
tcttcttgg  tgccttcac  tggatgttc  tggaggggg  gcagcttta  atcatgctg  3420
tggaggttt  tgagagtga  cattcacgt  ggaaatact  ttatctggt  ggctatggg  3480
tgcctgcac  cattgtggc  gtgtcagct  cagtagact  caggagtta  ggaacagat  3540
aagtatgtt  gctccgact  gacacctac  tcatttgga  ttttatagg  ccagcaact  3600
tgataatta  gcttaatgt  atcttcctt  ggattgctt  atataaaat  tttcatcat  3660
ctgctatac  gaaacctga  tcaggctgt  ttgataaca  caactatga  gataacaga  3720
ccttcatca  gtcatgggt  ataggtgca  tagctcttc  ctgcctatt  ggattgacc  3780
gggcctttg  actcatgta  attaatgaa  gcacagtca  catggccta  ctcttcacc  3840
ttttcaatt  tctacaggg  atgtttata  ttattttcc  ttgtgtcct  cagaagaag  3900
tacgaaaag  gtatgggaa  tgcctgcga  cacattgct  tagtggcaa  agtacagag  3960
gttccattg  ttcagggaa  acatctggt  ctcgaactc  tggacgcta  tccacaggc  4020
cacagagcc  aatccgtag  atgtggaat  acacggttc  aaagcagtc  gagtcttcc  4080
ttattactg  agacataaa  agttcagcg  cactcaaca  agagcccta  agagagaca  4140
gtatgggag  aaagctaaa  attgcatat  aaatagggg  ttctgaaca  tgccaggga  4200
acaagtgtc  tggatactc  accactgaa  ggtaaccat  gcaatagtt  cagcattgc  4260
agcggcgaa  acctgagca  ctgtgtgca  atcatagac  gtggctata  ccataacga  4320
accgcccta  agaaaaaga  tctgaagga  ctcactccc  actatatcc  ttcttacct  4380
aacaaccat  agcgctcca  tgaacagaa  aggaatctg  tgaacaagc  ggtgaataa  4440
cttggcagt  gaagggaag  tgatgccat  gtcctggat  atgccacct  gtttaacca  4500
gaggagagt  tgggcctgg  actcattca  gaggaatct  atgctcctt  gctgccccc  4560
agagtatac  ccaccgaga  ccaccagcc  caccattat  ccagaaggc  gatccccca  4620
gaccacagt  agagctttt  ccctttgct  accaacgag  acacagaag  tctccagtc  4680
ccccataga  actctctct  taccagcat  ccgacactg  ctggtgtgg  cgccacaga  4740
agtgttacc  ccagcaccc  gaccgaacc  ccaccggcc  aatgtggtg  tgccgaaga  4800
gtttactac  aaagcatgc  aaacctagg  tccagaaac  acgtccatc  gctgcatac  4860
tactaccag  taggtcgcg  cagcagtga  ggatttata  ttcctccaa  caaagatgg  4920
acccctccc  agggaagtt  aaaaggacc  gctcatttg  tcactagtc  atagaagat  4980
acacagaaa  tggaaccaa  aaaactgct  acaccttgt  gactgttct  agttgatat  5040
agcagtggt  ataatgtgt  tactcctaa  tctttatgc  gtcctctaa  gacaaacac  5100
aactctcag  ctttttttt  tttaatggg  tttttaggt  agcccaggg  agaaagata  5160
ctgctaaaa  tcccctgta  cccatcctt  cttgtcctt  ccccttcag  tggagactt  5220
attatgtta  tgaacaaga  atgaagaaa  tggcactca  tgtggcctt  ttgaattat  5280
ttgtgtatg  tttaacatc  ctgatgctg  gttactaaa  ttacaagga  ctgcttttt  5340
aaaggccag  acaattgtc  gaaattagt  acaatgctg  atctagatt  gagtgctgc  5400
caaacaaac  taagagcaa  gcaaaactg  atcacatag  gtttttggt  actcacaac  5460
tgaattcac  acagctgga  tagctgtgg  aaacaaaat  aaacaacaa  attaataat  5520
aaatggagg  gaattctag  attatatgc  aaatgcata  tttatgatt  gctgtatta  5580
ctgatgata  aactaatgg  agaaaaaga  gttgagcaa  ttctatgta  tgtacagat  5640
ctagcattg  acatatagt  tgctttctg  tcctccaga  tttgagtcc  gttaatgta  5700
tagaaaaaa  aaaaagaaa  tttcttttt  ttttgtgct  gtcttgcaa  tttgtctac  5760
agtaagaga  caaagtttc  ttcctttct  ctctttctt  attttcttt  tttcttttt  5820
gccttttat  cctttaaaa  ttcgcctgg  aaaaaataa  taaatggaa  tatcacttt  5880
taagaatca  tttctagta  tgcaaacaa  ttatttttt  caaaaaaac  aaataaata  5940
aattagact  ccttccctc  ctatatatc  ttatgcagt  agaatattt  caacagtgt  6000
ttttgcaaa  tagagcagg  caaactttt  tgtttacag  gcacgtctg  tgtaatgca  6060
agcatattt  gcaagcagt  catcaccag  acactagct  tgattctag  agtcaaaag  6120
tgtctatag  actagtggg  cttctgcat  tgaaaaacg  ttttccata  gcattaaag  6180
gctgaatgc  cagtctgat  aacaagtgg  cacctgcac  accactttt  agaggaaat  6240
cactccctc  taagcattg  aaggtcaaa  tattttgaa  tgatttttt  taaaaaaaa  6300
tcttctgtt  attaacagg  aaatttatt  atttgacag  attttgagt  atgtaggaa  6360
acaaaaggt  aattagcag  acatataat  tttttttaa  ttatgatcc  ttttgtatg  6420
tctcaaagt  ggatgacct  attactaat  tttgttgta  aagtgaaac  tgtttgcca  6480
ccaataaac  actgattga  atttagaag  tattgtaaa  aaaaaaaaa  aaa  6533



<210> 985
<211> 1241
<212> PRT
<213> Homo sapiens
<308> AF307080
<400> 985

Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
  1               5                  10                  15
Ile His Ala Phe Ser Arg Ala Pro Ile Pro Met Ala Val Val Arg Arg 
             20                  25                  30
Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg Cys Pro Gly Thr 
         35                  40                  45
Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg Thr Asp Asp Lys 
     50                  55                  60
Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile Arg Cys Tyr Leu 
 65                  70                  75                  80
Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn Asn Arg Thr Gln 
                 85                  90                  95
Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp Pro Cys Pro Gly 
             100                105                110
Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val Pro Tyr Lys Val 
         115                120                125
Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys Gly Val Tyr Gln 
     130                135                140
Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly Ala Trp Cys Lys 
 145                150                155                160
Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met Pro Trp Thr Pro 
                 165                170                175
Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ser Ser Lys Asp Asp Phe Ile 
             180                185                190
Ala Gly Arg Pro Thr Thr Thr Tyr Lys Leu Pro His Arg Val Asp Gly 
         195                200                205
Thr Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe Asn Lys Glu Arg 
     210                215                220
Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr Arg Ile Lys Ser Gly 
 225                230                235                240
Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Thr Ser Pro Tyr Arg 
                 245                250                255
Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu 
             260                265                270
Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly Lys Ile Val Ile Ser 
         275                280                285
Gln Leu Asn Pro Tyr Thr Leu Arg Ile Glu Gly Thr Trp Asp Thr Ala 
     290                295                300
Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile Cys Gly Ile Leu 
 305                310                315                320
Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn Glu Ala Thr Gly 
                 325                330                335
Asn Lys Ile Asp Tyr Ile Tyr Asn Thr Asp Gln Ser Lys Asp Ser Leu 
             340                345                350
Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile Ala Ala Val Asp 
         355                360                365
Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn Asn Tyr His Val 
     370                375                380
Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser Arg Ser Gly Gln 
 385                390                395                400
Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro Ile His Leu Asp 
                 405                410                415
Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser Thr Thr Gly Pro 
             420                425                430
Leu Gly Met Gly Ser Thr Thr Thr Ser Thr Thr Leu Arg Thr Thr Thr 
         435                440                445
Leu Ser Pro Gly Arg Ser Thr Thr Pro Ser Val Ser Gly Arg Arg Asn 
     450                455                460
Arg Ser Thr Ser Thr Pro Ser Pro Ala Val Glu Val Leu Asp Asp Met 
 465                470                475                480
Thr Thr His Leu Pro Ser Ala Ser Ser Gln Ile Pro Ala Leu Glu Glu 
                 485                490                495
Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe Lys Thr Arg 
             500                505                510
Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly Thr Ile Gly Val 
         515                520                525
Ser Thr Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp Pro Gln Gly 
     530                535                540
Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His Ile Thr Gln 
 545                550                555                560
Lys Leu Lys Ser Gly Glu Thr Ala Ala Asn Ile Ala Arg Glu Leu Ala 
                 565                570                575
Glu Gln Thr Arg Asn His Leu Asn Ala Gly Asp Ile Thr Tyr Ser Val 
             580                585                590
Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln Leu Arg Asn 
         595                600                605
Leu Thr Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu Asn Lys Leu 
     610                615                620
Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala Met Val Glu 
 625                630                635                640
Thr Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala Trp Arg Asp 
                 645                650                655
Leu Thr Thr Ser Asp Gln Leu Arg Ala Ala Thr Met Leu Leu His Thr 
             660                665                670
Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu Lys Thr Asp 
         675                680                685
Ile Val Arg Glu Asn Thr Asp Asn Ile Lys Leu Glu Val Ala Arg Leu 
     690                695                700
Ser Thr Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu Asn Met Gly 
 705                710                715                720
His Gly Ser Thr Ile Gln Leu Ser Ala Asn Thr Leu Lys Gln Asn Gly 
                 725                730                735
Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn Asn Leu Gly 
             740                745                750
Pro Tyr Leu Ser Thr Glu Asn Ala Ser Met Lys Leu Gly Thr Glu Ala 
         755                760                765
Leu Ser Thr Asn His Ser Val Ile Val Asn Ser Pro Val Ile Thr Ala 
     770                775                780
Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala Asp Pro Val 
 785                790                795                800
Val Phe Thr Val Lys His Ile Lys Gln Ser Glu Glu Asn Phe Asn Pro 
                 805                810                815
Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Thr Met Thr Gly Tyr Trp 
             820                825                830
Ser Thr Gln Gly Cys Arg Leu Leu Thr Thr Asn Lys Thr His Thr Thr 
         835                840                845
Cys Ser Cys Asn His Leu Thr Asn Phe Ala Val Leu Met Ala His Val 
     850                855                860
Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu Asp Val Ile 
 865                870                875                880
Thr Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu Ile Cys Ile 
                 885                890                895
Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Thr Ile 
             900                905                910
His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu Leu Phe Leu 
         915                920                925
Ile Gly Ile Asn Arg Thr Asp Gln Pro Ile Ala Cys Ala Val Phe Ala 
     930                935                940
Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Thr Trp Met Phe Leu 
 945                950                955                960
Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe Glu Ser Glu 
                 965                970                975
His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly Met Pro Ala 
             980                985                990
Leu Ile Val Ala Val Ser Ala Ala Val Asp Tyr Arg Ser Tyr Gly Thr 
         995                1000                1005
Asp Lys Val Cys Trp Leu Arg Leu Asp Thr Tyr Phe Ile Trp Ser Phe 
     1010                1015                1020
Ile Gly Pro Ala Thr Leu Ile Ile Met Leu Asn Val Ile Phe Leu Gly 
 1025                1030                1035                1040
Ile Ala Leu Tyr Lys Met Phe His His Thr Ala Ile Leu Lys Pro Glu 
                 1045                1050                1055
Ser Gly Cys Leu Asp Asn Ile Asn Tyr Glu Asp Asn Arg Pro Phe Ile 
             1060                1065                1070
Lys Ser Trp Val Ile Gly Ala Ile Ala Leu Leu Cys Leu Leu Gly Leu 
         1075                1080                1085
Thr Trp Ala Phe Gly Leu Met Tyr Ile Asn Glu Ser Thr Val Ile Met 
     1090                1095                1100
Ala Tyr Leu Phe Thr Ile Phe Asn Ser Leu Gln Gly Met Phe Ile Phe 
 1105                1110                1115                1120
Ile Phe His Cys Val Leu Gln Lys Lys Val Arg Lys Glu Tyr Gly Lys 
                 1125                1130                1135
Cys Leu Arg Thr His Cys Cys Ser Gly Lys Ser Thr Glu Ser Ser Ile 
             1140                1145                1150
Gly Ser Gly Lys Thr Ser Gly Ser Arg Thr Pro Gly Arg Tyr Ser Thr 
         1155                1160                1165
Gly Ser Gln Ser Arg Ile Arg Arg Met Trp Asn Asp Thr Val Arg Lys 
     1170                1175                1180
Gln Ser Glu Ser Ser Phe Ile Thr Gly Asp Ile Asn Ser Ser Ala Ser 
 1185                1190                1195                1200
Leu Asn Arg Glu Pro Tyr Arg Glu Thr Ser Met Gly Val Lys Leu Asn 
                 1205                1210                1215
Ile Ala Tyr Gln Ile Gly Ala Ser Glu Gln Cys Gln Gly Tyr Lys Cys 
             1220                1225                1230
His Gly Tyr Ser Thr Thr Glu Trp Ter 
         1235                1240



<210> 986
<211> 5413
<212> DNA
<213> Rattus norvegicus
<308> AF063103
<400> 986

aatcattga  attggaata  agaagagga  ccagaagta  actgatttg  cttcacctc  60
gaacagcca  tcttgaggc  ttctcctcc  agaacacag  catgtgtcc  cctcagctg  120
tcatcctca  gatgctttt  gcacctgta  ttcatggtg  caagcacaa  gagagacat  180
cagccctcg  tgctccact  cgacatgct  agcacagcc  aggaggccc  ctccctccc  240
gacatcttc  tcagcagcc  gctgcagag  gctctacag  tcatcgagg  caagggcca  300
gtggaactg  cagaggagt  cgcggaccc  gtgccccag  agcacagat  gcagcccaa  360
ctttcagcc  tgccccaat  cccatggca  tggtccgca  agagctctc  tgtgagagc  420
accccattg  gctacgctg  ccaggcaca  acgtcatca  gatcgaaag  gccaactac  480
ggaggacag  tgacaagat  tgtgactcg  accctgctc  gatggagaa  attcggtgt  540
atctgccag  tgcctataa  attatgtct  aaagatgca  taacagaac  cagtgtgca  600
tggtggcag  tcctgatgt  tttccagac  catgtccgg  aacatataa  taccttgaa  660
tgcagtatg  atgtgtccc  tacaaagtg  aacaaaaag  ttttctttg  cccggactg  720
tcaaaggag  gtaccagag  gaacacttg  ttgaatctg  ccaccaatc  ggggcatgg  780
gcaaagacc  tctacaggc  tctgacaag  tttactata  gccctggac  ccctacaga  840
ccgataccc  gacagagta  tcatccaaa  atgacttca  tgctggaag  ccgacaact  900
catacaagc  ccctcacag  gtggatggt  ctggatttg  agtatatga  ggtgccctg  960
tcttcaaca  ggagcgtac  aggaacata  taaagtttg  tttgaggac  aggataaag  1020
gtggagagg  aatcatagc  aatgctaac  accatgata  ctccccata  cgatggggt  1080
gcaagtccg  catagactt  gcagtggat  aaaacggat  atgggtaat  tatgcaaca  1140
aacagaaca  tggcaaaat  gttattagc  agttgaacc  ttacaccct  cggattgag  1200
ggacatggg  cactgccta  gataaaagg  ctgcttcca  tgcatttat  atttgtggg  1260
ttctgtatg  ggtcaagtc  gtatatgag  atgacgaca  tgaggccac  ggtaataag  1320
ttgactaca  ttacaatac  gaccaaagc  aggatagcc  ggtggatgt  ccctttccc  1380
actcatacc  gtacatagc  gccgtggac  acaatccca  ggacaatct  ctgtacgtg  1440
ggaacaact  ccatgttgt  aaatactcc  tggacttcg  gcctctgga  agcagatca  1500
ggccagtgc  tcatggaca  gtttcctac  tctctccac  gattcacct  gactctgac  1560
tggaaaggc  ccctgtcag  gggatttct  ccacaggac  cctgggtat  ggaagcacg  1620
ccaccagca  caccctccg  actaccacc  ggaacctag  gaggagtac  acgccatcc  1680
tgcctggca  aagaaaccg  agtaccagt  cgccgtccc  agcgattga  gtgctggat  1740
ttaccacac  cctgccatc  gcagcctcc  aaatcccag  gatggaaga  agctgcgag  1800
ctgtggaag  ccgagagat  atgtggttt  agacccgac  ggggcaagt  gcaaagcag  1860
catgcccag  aggaaccat  ggtgtatca  cttacctgt  tcttgctcc  gatggaata  1920
gggatcccc  aggaccaga  ctcagcaac  gctcttctc  ttgggtcaa  cacataaca  1980
agaagctga  atctggaga  acagctgcc  atattgcca  agagctagc  gaacagacc  2040
gaaatcatt  gaacgccgg  gatatcacc  actcagttc  tgccatgga  caactggtt  2100
gcctcctgg  cgtacagct  aggaatttg  caccagggg  gaaggacag  gctgcccga  2160
gcttgaaca  gcttcagaa  agagagcgc  cttgcagag  ctatgtcca  gcgatggtg  2220
agacagtta  caatctcct  cagccacaa  ctctgaatg  gtggaggga  ctgacgaca  2280
gtgatcaac  acgcgcagc  accatgttg  tcgacactg  ggaggagag  gctttcgtg  2340
tagccgata  ccttttgaa  accgacatt  tcagggaga  tacagacaa  attcagttg  2400
aggttgcaa  gctgagcac  gaaggaaac  tagaagatc  aaaatttcc  gaaaacacg  2460
gccacggaa  cactataca  ctttccgca  acacgttaa  gcaaaatgg  cggaatgga  2520
agattagag  ggcctttgt  ctgtataac  acctgggtc  ttatttatc  acggagaat  2580
ccagtatga  gttgggcac  gaagctatg  ccacaaatc  ctcagttat  gtcaattcc  2640
ctgttatta  agcagcaat  aataaggaa  tcagtaata  agtgtattt  gctgatcct  2700
tggtattta  tgttaaaca  atcaagcag  cagaggaaa  tttcaaccc  aactgttca  2760
tttggagct  ttccaagcg  acaatgaca  gttattggt  aacacaagg  tgtcgactc  2820
tgacaacga  caagacaca  actacgtgc  cctgtaacc  cctcaccaa  ttcgcagta  2880
taatggcac  tgtggaagt  aagcacagc  atgccgtcc  cgatcttct  ctggatgtg  2940
tcacgtggg  cggaatcct  ttgtctctt  tttgtctcc  gatctgcat  ttcacattc  3000
gcttcttcc  tgggcttca  agcgaccgt  acaccattc  caagaacct  tgcatcagc  3060
tgtttgtgg  agaactgct  ttcctgatt  ggatcaaca  aaccgacca  ccgattgcc  3120
gtgcagtgt  tgcggctct  ttgcatttc  tcttcttgg  ggccttcac  tggatgttt  3180
tagaagggg  acagctgta  atcatgctg  tggaggtct  tgagagtga  cattcccgt  3240
ggaagtact  ctatctggt  ggctacggg  tgcccgcac  catcgtggc  gtttctgct  3300
cagtcgact  caggagcta  ggaacagac  aagtatgtt  gcttcgcct  gacacctac  3360
tcatttgga  ttttatagg  ccagcgacc  tgataatta  gctgaatgt  atcttcctc  3420
ggattgctt  atacaaaat  tttcaccat  ctgccatac  gaaacctga  tcaggctgt  3480
ttgataata  caactatga  gataacaga  ccttcatca  gtcatgggt  ataggtgca  3540
tagcgctgc  ctgcctatt  ggattgacc  gggcctttg  actcatgta  attaatgaa  3600
gcacagtca  catggcgta  ctcttcacc  ttttcaatt  tctacaggg  atgtttata  3660
tcattttcc  ctgtgtcct  cagaagaag  tacggaaag  gtatgggaa  tgcctacgg  3720
cgcattgct  tagtgggaa  agcacggag  gttcgattg  ctcagggaa  acatctggt  3780
ctcgaactc  aggacggta  tccacaggc  cacagagcc  gattcggag  atgtggaat  3840
acaccgtcc  aaagcagtc  gagtcatcc  tcatcactg  agacataaa  agctcagcg  3900
cgctcaaca  aggatccta  cttccctgc  ttcaggcgt  tgtaacata  ttagagggg  3960
ttctgaaca  tgccaggga  acaagtgtc  tggatactc  accactgaa  ggtaaccat  4020
gcaacagtt  cagcattgc  ggcggcgaa  acctgagca  ctgtgtgca  attatagac  4080
gtggctata  ccacaacga  accgcccta  aaaaaaaga  cctaaagga  ctcacttcc  4140
actatatcc  ttcatacct  aacaaccac  agcgctcca  cgaacagaa  cggaacatg  4200
tgaacaaac  ggtggacaa  ttaggcagt  ggagtgaag  tgacgccat  gtcctggat  4260
acgcagcgt  ctttaacca  gaggagagt  tgggcctgg  actcattca  gaggaatcg  4320
atgctccct  gctgccccc  agggtttac  ccaccgata  ccaccagcc  caccattac  4380
gcaggaggc  gctccccca  gaccacagc  agagcttct  ccctctgct  accgacgag  4440
acacagaag  cccgcagtc  ccgcacagg  actctctgt  caccagcat  ccggccctg  4500
ccggtgtgc  cgctgcaga  agtgtgacc  ccagcaccc  gaccgaagc  gcagcggcc  4560
agggtggtg  cgccgaaga  gtttactac  aaagcatgc  aaacctggg  tccagaaac  4620
atgtgcacc  gctgcacgc  tactaccag  tagggcgag  cagcagcga  ggattcata  4680
ttcctccca  taaagatgg  gcctctccg  aggggactt  caaaggacc  gcgcacttg  4740
tcactagtc  atagaaggt  acacgggga  gacaaccaa  gggacagct  acacccggt  4800
gcccattct  agtcgatat  agcagtggt  atcgtgtgt  acacgtgtg  gacatctga  4860
gctgatctc  aaagagaga  tctgacatt  ggttttttt  ttttttttt  aacttgaat  4920
tttaggtca  cgcagggga  aaagctccc  ctgtgcccc  gtctttccc  tctttcccc  4980
cagatggac  cttcattat  ttaatgaac  agataagat  aaaatggcg  tcattgtgg  5040
cctgttgag  taggttgtg  ttaacagct  tgatgctct  ttactagaa  cacgaggac  5100
tgatttttc  ttctttttt  tttttttaa  aaaaaagag  ccggaacta  tgtttggaa  5160
tagtaacaa  gctgcatct  gattggagt  ctgcccagc  gtagaagca  agcagaact  5220
tatcccata  cggtgcgcg  tcactcgca  cctgagttc  ccacagcga  catagctgt  5280
aaaagcaaa  gcaaaacaa  agaattaat  atctgacgg  ggggaattc  agaattata  5340
gctaaatgc  tattttatg  tttgctgta  taactgatg  taaaactaa  ggcagaaaa  5400
aaaaaaaaa  aaa  5413



<210> 987
<211> 1550
<212> PRT
<213> Rattus norvegicus
<308> AAC77816
<400> 987

Met Cys Pro Pro Gln Leu Phe Ile Leu Met Met Leu Leu Ala Pro Val 
  1               5                  10                  15
Val His Gly Gly Lys His Asn Glu Arg His Pro Ala Leu Ala Ala Pro 
             20                  25                  30
Leu Arg His Ala Glu His Ser Pro Gly Gly Pro Leu Pro Pro Arg His 
         35                  40                  45
Leu Leu Gln Gln Pro Ala Ala Glu Arg Ser Thr Ala His Arg Gly Gln 
     50                  55                  60
Gly Pro Arg Gly Thr Ala Arg Gly Val Arg Gly Pro Gly Ala Pro Gly 
 65                  70                  75                  80
Ala Gln Ile Ala Ala Gln Ala Phe Ser Arg Ala Pro Ile Pro Met Ala 
                 85                  90                  95
Val Val Arg Arg Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg 
             100                105                110
Cys Pro Gly Thr Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg 
         115                120                125
Thr Asp Asp Lys Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile 
     130                135                140
Arg Cys Tyr Leu Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn 
 145                150                155                160
Asn Arg Thr Gln Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp 
                 165                170                175
Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val 
             180                185                190
Pro Tyr Lys Val Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys 
         195                200                205
Gly Val Tyr Gln Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly 
     210                215                220
Ala Trp Cys Lys Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met 
 225                230                235                240
Pro Trp Thr Pro Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ser Ser Lys 
                 245                250                255
Asp Asp Phe Ile Ala Gly Arg Pro Thr Thr Thr Tyr Lys Leu Pro His 
             260                265                270
Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe 
         275                280                285
Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr Arg 
     290                295                300
Ile Lys Ser Gly Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Thr 
 305                310                315                320
Ser Pro Tyr Arg Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp 
                 325                330                335
Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly Lys 
             340                345                350
Ile Val Ile Ser Gln Leu Asn Pro Tyr Thr Leu Arg Ile Glu Gly Thr 
         355                360                365
Trp Asp Thr Ala Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile 
     370                375                380
Cys Gly Ile Leu Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn 
 385                390                395                400
Glu Ala Thr Gly Asn Lys Ile Asp Tyr Ile Tyr Asn Thr Asp Gln Ser 
                 405                410                415
Lys Asp Ser Leu Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile 
             420                425                430
Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn 
         435                440                445
Asn Tyr His Val Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser 
     450                455                460
Arg Ser Gly Pro Val His His Gly Gln Val Ser Tyr Ile Ser Pro Pro 
 465                470                475                480
Ile His Leu Asp Ser Asp Leu Glu Arg Pro Pro Val Arg Gly Ile Ser 
                 485                490                495
Thr Thr Gly Pro Leu Gly Met Gly Ser Thr Thr Thr Ser Thr Thr Leu 
             500                505                510
Arg Thr Thr Thr Trp Asn Leu Gly Arg Ser Thr Thr Pro Ser Leu Pro 
         515                520                525
Gly Arg Arg Asn Arg Ser Thr Ser Thr Pro Ser Pro Ala Ile Glu Val 
     530                535                540
Leu Asp Val Thr Thr His Leu Pro Ser Ala Ala Ser Gln Ile Pro Ala 
 545                550                555                560
Met Glu Glu Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe 
                 565                570                575
Lys Thr Arg Gln Gly Gln Val Ala Lys Gln Ser Cys Pro Ala Gly Thr 
             580                585                590
Ile Gly Val Ser Thr Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp 
         595                600                605
Pro Gln Gly Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His 
     610                615                620
Ile Thr Gln Lys Leu Lys Ser Gly Glu Thr Ala Ala Asn Ile Ala Arg 
 625                630                635                640
Glu Leu Ala Glu Gln Thr Arg Asn His Leu Asn Ala Gly Asp Ile Thr 
                 645                650                655
Tyr Ser Val Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln 
             660                665                670
Leu Arg Asn Leu Thr Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu 
         675                680                685
Asn Lys Leu Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala 
     690                695                700
Met Val Glu Thr Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala 
 705                710                715                720
Trp Arg Asp Leu Thr Thr Ser Asp Gln Leu Arg Ala Ala Thr Met Leu 
                 725                730                735
Leu Asp Thr Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu 
             740                745                750
Lys Thr Asp Ile Val Arg Glu Asn Thr Asp Asn Ile Gln Leu Glu Val 
         755                760                765
Ala Arg Leu Ser Thr Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu 
     770                775                780
Asn Thr Gly His Gly Ser Thr Ile Gln Leu Ser Ala Asn Thr Leu Lys 
 785                790                795                800
Gln Asn Gly Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn 
                 805                810                815
Asn Leu Gly Pro Tyr Leu Ser Thr Glu Asn Ala Ser Met Lys Leu Gly 
             820                825                830
Thr Glu Ala Met Ser Thr Asn His Ser Val Ile Val Asn Ser Pro Val 
         835                840                845
Ile Thr Ala Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala 
     850                855                860
Asp Pro Val Val Phe Thr Val Lys His Ile Lys Gln Ser Glu Glu Asn 
 865                870                875                880
Phe Asn Pro Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Thr Met Thr 
                 885                890                895
Gly Tyr Trp Ser Thr Gln Gly Cys Arg Leu Leu Thr Thr Asn Lys Thr 
             900                905                910
His Thr Thr Cys Ser Cys Asn His Leu Thr Asn Phe Ala Val Leu Met 
         915                920                925
Ala His Val Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu 
     930                935                940
Asp Val Ile Thr Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu 
 945                950                955                960
Ile Cys Ile Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg 
                 965                970                975
Asn Thr Ile His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu 
             980                985                990
Leu Phe Leu Ile Gly Ile Asn Arg Thr Asp Gln Pro Ile Ala Cys Ala 
         995                1000                1005
Val Phe Ala Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Thr Trp 
     1010                1015                1020
Met Phe Leu Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe 
 1025                1030                1035                1040
Glu Ser Glu His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly 
                 1045                1050                1055
Met Pro Ala Leu Ile Val Ala Val Ser Ala Ala Val Asp Tyr Arg Ser 
             1060                1065                1070
Tyr Gly Thr Asp Lys Val Cys Trp Leu Arg Leu Asp Thr Tyr Phe Ile 
         1075                1080                1085
Trp Ser Phe Ile Gly Pro Ala Thr Leu Ile Ile Met Leu Asn Val Ile 
     1090                1095                1100
Phe Leu Gly Ile Ala Leu Tyr Lys Met Phe His His Thr Ala Ile Leu 
 1105                1110                1115                1120
Lys Pro Glu Ser Gly Cys Leu Asp Asn Ile Asn Tyr Glu Asp Asn Arg 
                 1125                1130                1135
Pro Phe Ile Lys Ser Trp Val Ile Gly Ala Ile Ala Leu Leu Cys Leu 
             1140                1145                1150
Leu Gly Leu Thr Trp Ala Phe Gly Leu Met Tyr Ile Asn Glu Ser Thr 
         1155                1160                1165
Val Ile Met Ala Tyr Leu Phe Thr Ile Phe Asn Ser Leu Gln Gly Met 
     1170                1175                1180
Phe Ile Phe Ile Phe His Cys Val Leu Gln Lys Lys Val Arg Lys Glu 
 1185                1190                1195                1200
Tyr Gly Lys Cys Leu Arg Thr His Cys Cys Ser Gly Lys Ser Thr Glu 
                 1205                1210                1215
Ser Ser Ile Gly Ser Gly Lys Thr Ser Gly Ser Arg Thr Pro Gly Arg 
             1220                1225                1230
Tyr Ser Thr Gly Ser Gln Ser Arg Ile Arg Arg Met Trp Asn Asp Thr 
         1235                1240                1245
Val Arg Lys Gln Ser Glu Ser Ser Phe Ile Thr Gly Asp Ile Asn Ser 
     1250                1255                1260
Ser Ala Ser Leu Asn Arg Gly Ser Tyr Leu Pro Cys Ile Gln Ala Cys 
 1265                1270                1275                1280
Val Thr Tyr Leu Glu Gly Leu Leu Asn Asn Ala Arg Asp Thr Ser Val 
                 1285                1290                1295
Met Asp Thr Leu Pro Leu Asn Gly Asn His Gly Asn Ser Tyr Ser Ile 
             1300                1305                1310
Ala Gly Gly Glu Tyr Leu Ser Asn Cys Val Gln Ile Ile Asp Arg Gly 
         1315                1320                1325
Tyr Asn His Asn Glu Thr Ala Leu Glu Lys Lys Ile Leu Lys Glu Leu 
     1330                1335                1340
Thr Ser Asn Tyr Ile Pro Ser Tyr Leu Asn Asn His Glu Arg Ser Ser 
 1345                1350                1355                1360
Glu Gln Asn Arg Asn Met Met Asn Lys Leu Val Asp Asn Leu Gly Ser 
                 1365                1370                1375
Gly Ser Glu Asp Asp Ala Ile Val Leu Asp Asp Ala Ala Ser Phe Asn 
             1380                1385                1390
His Glu Glu Ser Leu Gly Leu Glu Leu Ile His Glu Glu Ser Asp Ala 
         1395                1400                1405
Pro Leu Leu Pro Pro Arg Val Tyr Ser Thr Asp Asn His Gln Pro His 
     1410                1415                1420
His Tyr Ser Arg Arg Arg Leu Pro Gln Asp His Ser Glu Ser Phe Phe 
 1425                1430                1435                1440
Pro Leu Leu Thr Asp Glu His Thr Glu Asp Pro Gln Ser Pro His Arg 
                 1445                1450                1455
Asp Ser Leu Tyr Thr Ser Met Pro Ala Leu Ala Gly Val Pro Ala Ala 
             1460                1465                1470
Asp Ser Val Thr Thr Ser Thr Gln Thr Glu Ala Ala Ala Ala Lys Gly 
         1475                1480                1485
Gly Asp Ala Glu Asp Val Tyr Tyr Lys Ser Met Pro Asn Leu Gly Ser 
     1490                1495                1500
Arg Asn His Val His Pro Leu His Ala Tyr Tyr Gln Leu Gly Arg Gly 
 1505                1510                1515                1520
Ser Ser Asp Gly Phe Ile Val Pro Pro Asn Lys Asp Gly Ala Ser Pro 
                 1525                1530                1535
Glu Gly Thr Ser Lys Gly Pro Ala His Leu Val Thr Ser Leu 
             1540                1545                1550



<210> 988
<211> 6533
<212> DNA
<213> Homo sapiens
<308> AF307080
<400> 988

gaaaaacac  agccgtgtt  tatgtggag  ccccggtgt  tgggtgtaa  tctcgttcc  60
tctgtgagg  gaggcagat  aagccattt  gtggttctg  tgagcatgg  cttggcagt  120
tttttggga  catcacact  tgccccttt  gttaacttg  tagcccggc  tgtcttttg  180
cccgggctc  atggctgga  tgtggaaac  gcacccgcc  tcaggttgt  gagcaactg  240
tgggacgat  tcagggacc  gcgtttacg  aagaaatgt  taatttggt  aattggagg  300
aaaaaacat  gatttttag  aattgaaga  caaattaag  tttcagatt  gggatattg  360
tgtttctgt  ttggagaaa  tattctttt  ctttttaat  tgaagaaaa  tcatcagtc  420
tggaataca  aagagaaac  agaaatata  gtattttgt  tcacatttg  acagtcatt  480
ttgaggaat  ctccatacc  gagtagaca  ccatgtggc  atcgcagct  ctaattttc  540
tgatgctct  agctccaat  attcatgct  tcagccgtg  cccaattcc  atggctgtg  600
tccgcagag  gctatcctg  gagagctat  ctatagagc  tcgctgtcc  ggaacagac  660
tcatcatga  agaaagtgc  aactatggc  ggactgatg  caaaatttg  gactctgac  720
ctgctcaga  ggagaatat  cgatgttat  tgccagatg  ctataagat  atgtctcaa  780
gatgcaata  cagaaccca  tgtgcagtg  tggcaggtc  tgatgtttt  ccagacccg  840
gtccaggaa  ctataaata  cttgaagtg  agtatgaat  tgtccctta  aaagtggaa  900
aaaaagttt  tctttgtcc  ggactacta  aaggagtat  ccagagtga  catttgttt  960
agtccgacc  ccaatctgg  gcgtggtgc  aagaccctc  gcaggcatc  gacaagatt  1020
attatatgc  ctggactcc  tacagaact  ataccctga  tgagtattc  tccaaggat  1080
acttcattg  tggaagacc  actacaacc  acaagctcc  tcatagggt  gatggcaca  1140
gatttgtag  gtatgatgg  gctttgttc  tcaacaaag  gcgcaccag  aacatagta  1200
agtttgatt  gcggactag  ataaagagt  gagaggcta  catagcaaa  gccaattac  1260
atgatacct  cccttaccg  tggggaggc  aatctgaca  agacctggc  gtagatgag  1320
atgggctat  ggtaatcta  gcaacagaa  aaaacaatg  taaaattgt  attagtcaa  1380
tgaaccctt  caccctacg  atcgaagga  catgggata  tgcatatga  aaaaggtca  1440
cttccaatg  ctttatgat  tgtggaatt  tgtatgtgg  caaatctgt  tatgaggat  1500
atgacaatg  ggctactgg  aataagatt  actacattt  caacactga  caaagcaag  1560
atagtttgg  ggatgtacc  tttcctaat  cataccagt  cattgcagc  gtggattac  1620
accccaggg  caacctact  tatgtatgg  ataactatc  cgtcgtgaa  tattctttg  1680
attttggac  tctggatag  agatcaggg  aggcacatc  tggacaagt  tcatacatt  1740
ctccgccaa  tcaccttga  tctgagcta  aaagaccct  tgttaaaga  atctctacc  1800
caggacctc  tggcatggg  agcactacc  ccagtacca  ccttcggac  acaactttg  1860
gcccaggaa  gagtaccac  ccgtcagtg  caggaagaa  aaaccggag  actagtacc  1920
catctccag  tgtcgaggt  cttgatgac  tgaccacac  ccttccatc  gcatcgtcc  1980
aaatcccag  tctcgaaga  agctgtgag  ctgtggaag  ccgagaaat  atgtggttt  2040
agactcgtc  aggacagat  gcaaagcag  catgccctg  aggaactat  ggtgtatca  2100
cttatctat  ccttgctcc  gatggaatt  gggatcccc  aggtccaga  ctcagcaac  2160
gttcttctc  ttgggtcaa  catataaca  agaagttga  atctggtga  acagctgcc  2220
acattgcta  agagctggc  gaacagaca  gaaatcact  gaatgctgg  gacatcacc  2280
actctgtcc  ggccatgga  cagctggta  gcctcctag  tgtacagct  cggaacttg  2340
ccccaggtg  aaaagatag  gctgcccgg  gtttgaaca  gcttcagaa  agagagcgc  2400
cttgcagag  ctatgtcca  gcaatggtc  agacagtta  caacctcct  cagccacaa  2460
ctttgaatg  atggagaga  ctgactacg  gtgatcagc  gcgtgcggc  accatgttg  2520
ttcatactg  ggaggaaag  gcttttgtg  tggctgata  ccttttgaa  actgacatt  2580
tcagggaga  tacagacaa  attaaattg  aagttgcaa  actgagcac  gaaggaaac  2640
tagaagacc  aaaatttcc  gaaaacatg  gccatggaa  cactatcca  ctgtctgca  2700
ataccttaa  gcaaaatgg  cgaaatgga  agatcagag  ggcctttgt  ctgtataac  2760
acttgggtc  ttatttatc  acggagaat  ccagtatga  gttgggaac  gaagctttg  2820
ccacaaatc  ttctgttat  gtcaattcc  ctgttatta  ggcagcaat  aacaaagag  2880
tcagtaaca  ggtttattt  gctgatcct  tggtattta  tgttaaaca  atcaagcag  2940
cagaggaaa  tttcaaccc  aactgttca  tttggagct  ctccaagcg  acaatgaca  3000
gttattggt  aacacaagg  tgtcggctc  tgacaacaa  taagacaca  actacatgc  3060
cttgtaacc  cctaacaaa  tttgcagta  tgatggcac  tgtggaagt  aagcacagt  3120
atgcggtcc  tgacctcct  ctggatgtg  tcacgtggg  tggaatttt  ctgtccctt  3180
tttgtctcc  gatttgcat  ttcacattt  gctttttcc  cgggctcca  agtgaccgt  3240
acaccatcc  caagaacct  tgcatcagt  tctttgtag  agagctgct  ttcctgatt  3300
ggatcaacc  aactgacca  ccaattgcc  gtgctgttt  cgctgccct  ttacatttc  3360
tcttcttgg  tgccttcac  tggatgttc  tggaggggg  gcagcttta  atcatgctg  3420
tggaggttt  tgagagtga  cattcacgt  ggaaatact  ttatctggt  ggctatggg  3480
tgcctgcac  cattgtggc  gtgtcagct  cagtagact  caggagtta  ggaacagat  3540
aagtatgtt  gctccgact  gacacctac  tcatttgga  ttttatagg  ccagcaact  3600
tgataatta  gcttaatgt  atcttcctt  ggattgctt  atataaaat  tttcatcat  3660
ctgctatac  gaaacctga  tcaggctgt  ttgataaca  caactatga  gataacaga  3720
ccttcatca  gtcatgggt  ataggtgca  tagctcttc  ctgcctatt  ggattgacc  3780
gggcctttg  actcatgta  attaatgaa  gcacagtca  catggccta  ctcttcacc  3840
ttttcaatt  tctacaggg  atgtttata  ttattttcc  ttgtgtcct  cagaagaag  3900
tacgaaaag  gtatgggaa  tgcctgcga  cacattgct  tagtggcaa  agtacagag  3960
gttccattg  ttcagggaa  acatctggt  ctcgaactc  tggacgcta  tccacaggc  4020
cacagagcc  aatccgtag  atgtggaat  acacggttc  aaagcagtc  gagtcttcc  4080
ttattactg  agacataaa  agttcagcg  cactcaaca  agagcccta  agagagaca  4140
gtatgggag  aaagctaaa  attgcatat  aaatagggg  ttctgaaca  tgccaggga  4200
acaagtgtc  tggatactc  accactgaa  ggtaaccat  gcaatagtt  cagcattgc  4260
agcggcgaa  acctgagca  ctgtgtgca  atcatagac  gtggctata  ccataacga  4320
accgcccta  agaaaaaga  tctgaagga  ctcactccc  actatatcc  ttcttacct  4380
aacaaccat  agcgctcca  tgaacagaa  aggaatctg  tgaacaagc  ggtgaataa  4440
cttggcagt  gaagggaag  tgatgccat  gtcctggat  atgccacct  gtttaacca  4500
gaggagagt  tgggcctgg  actcattca  gaggaatct  atgctcctt  gctgccccc  4560
agagtatac  ccaccgaga  ccaccagcc  caccattat  ccagaaggc  gatccccca  4620
gaccacagt  agagctttt  ccctttgct  accaacgag  acacagaag  tctccagtc  4680
ccccataga  actctctct  taccagcat  ccgacactg  ctggtgtgg  cgccacaga  4740
agtgttacc  ccagcaccc  gaccgaacc  ccaccggcc  aatgtggtg  tgccgaaga  4800
gtttactac  aaagcatgc  aaacctagg  tccagaaac  acgtccatc  gctgcatac  4860
tactaccag  taggtcgcg  cagcagtga  ggatttata  ttcctccaa  caaagatgg  4920
acccctccc  agggaagtt  aaaaggacc  gctcatttg  tcactagtc  atagaagat  4980
acacagaaa  tggaaccaa  aaaactgct  acaccttgt  gactgttct  agttgatat  5040
agcagtggt  ataatgtgt  tactcctaa  tctttatgc  gtcctctaa  gacaaacac  5100
aactctcag  ctttttttt  tttaatggg  tttttaggt  agcccaggg  agaaagata  5160
ctgctaaaa  tcccctgta  cccatcctt  cttgtcctt  ccccttcag  tggagactt  5220
attatgtta  tgaacaaga  atgaagaaa  tggcactca  tgtggcctt  ttgaattat  5280
ttgtgtatg  tttaacatc  ctgatgctg  gttactaaa  ttacaagga  ctgcttttt  5340
aaaggccag  acaattgtc  gaaattagt  acaatgctg  atctagatt  gagtgctgc  5400
caaacaaac  taagagcaa  gcaaaactg  atcacatag  gtttttggt  actcacaac  5460
tgaattcac  acagctgga  tagctgtgg  aaacaaaat  aaacaacaa  attaataat  5520
aaatggagg  gaattctag  attatatgc  aaatgcata  tttatgatt  gctgtatta  5580
ctgatgata  aactaatgg  agaaaaaga  gttgagcaa  ttctatgta  tgtacagat  5640
ctagcattg  acatatagt  tgctttctg  tcctccaga  tttgagtcc  gttaatgta  5700
tagaaaaaa  aaaaagaaa  tttcttttt  ttttgtgct  gtcttgcaa  tttgtctac  5760
agtaagaga  caaagtttc  ttcctttct  ctctttctt  attttcttt  tttcttttt  5820
gccttttat  cctttaaaa  ttcgcctgg  aaaaaataa  taaatggaa  tatcacttt  5880
taagaatca  tttctagta  tgcaaacaa  ttatttttt  caaaaaaac  aaataaata  5940
aattagact  ccttccctc  ctatatatc  ttatgcagt  agaatattt  caacagtgt  6000
ttttgcaaa  tagagcagg  caaactttt  tgtttacag  gcacgtctg  tgtaatgca  6060
agcatattt  gcaagcagt  catcaccag  acactagct  tgattctag  agtcaaaag  6120
tgtctatag  actagtggg  cttctgcat  tgaaaaacg  ttttccata  gcattaaag  6180
gctgaatgc  cagtctgat  aacaagtgg  cacctgcac  accactttt  agaggaaat  6240
cactccctc  taagcattg  aaggtcaaa  tattttgaa  tgatttttt  taaaaaaaa  6300
tcttctgtt  attaacagg  aaatttatt  atttgacag  attttgagt  atgtaggaa  6360
acaaaaggt  aattagcag  acatataat  tttttttaa  ttatgatcc  ttttgtatg  6420
tctcaaagt  ggatgacct  attactaat  tttgttgta  aagtgaaac  tgtttgcca  6480
ccaataaac  actgattga  atttagaag  tattgtaaa  aaaaaaaaa  aaa  6533



<210> 989
<211> 1550
<212> PRT
<213> Homo sapiens
<308> AAC77816
<400> 989

Met Cys Pro Pro Gln Leu Phe Ile Leu Met Met Leu Leu Ala Pro Val 
  1               5                  10                  15
Val His Gly Gly Lys His Asn Glu Arg His Pro Ala Leu Ala Ala Pro 
             20                  25                  30
Leu Arg His Ala Glu His Ser Pro Gly Gly Pro Leu Pro Pro Arg His 
         35                  40                  45
Leu Leu Gln Gln Pro Ala Ala Glu Arg Ser Thr Ala His Arg Gly Gln 
     50                  55                  60
Gly Pro Arg Gly Thr Ala Arg Gly Val Arg Gly Pro Gly Ala Pro Gly 
 65                  70                  75                  80
Ala Gln Ile Ala Ala Gln Ala Phe Ser Arg Ala Pro Ile Pro Met Ala 
                 85                  90                  95
Val Val Arg Arg Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg 
             100                105                110
Cys Pro Gly Thr Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg 
         115                120                125
Thr Asp Asp Lys Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile 
     130                135                140
Arg Cys Tyr Leu Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn 
 145                150                155                160
Asn Arg Thr Gln Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp 
                 165                170                175
Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val 
             180                185                190
Pro Tyr Lys Val Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys 
         195                200                205
Gly Val Tyr Gln Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly 
     210                215                220
Ala Trp Cys Lys Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met 
 225                230                235                240
Pro Trp Thr Pro Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ser Ser Lys 
                 245                250                255
Asp Asp Phe Ile Ala Gly Arg Pro Thr Thr Thr Tyr Lys Leu Pro His 
             260                265                270
Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe 
         275                280                285
Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr Arg 
     290                295                300
Ile Lys Ser Gly Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Thr 
 305                310                315                320
Ser Pro Tyr Arg Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp 
                 325                330                335
Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly Lys 
             340                345                350
Ile Val Ile Ser Gln Leu Asn Pro Tyr Thr Leu Arg Ile Glu Gly Thr 
         355                360                365
Trp Asp Thr Ala Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile 
     370                375                380
Cys Gly Ile Leu Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn 
 385                390                395                400
Glu Ala Thr Gly Asn Lys Ile Asp Tyr Ile Tyr Asn Thr Asp Gln Ser 
                 405                410                415
Lys Asp Ser Leu Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile 
             420                425                430
Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn 
         435                440                445
Asn Tyr His Val Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser 
     450                455                460
Arg Ser Gly Pro Val His His Gly Gln Val Ser Tyr Ile Ser Pro Pro 
 465                470                475                480
Ile His Leu Asp Ser Asp Leu Glu Arg Pro Pro Val Arg Gly Ile Ser 
                 485                490                495
Thr Thr Gly Pro Leu Gly Met Gly Ser Thr Thr Thr Ser Thr Thr Leu 
             500                505                510
Arg Thr Thr Thr Trp Asn Leu Gly Arg Ser Thr Thr Pro Ser Leu Pro 
         515                520                525
Gly Arg Arg Asn Arg Ser Thr Ser Thr Pro Ser Pro Ala Ile Glu Val 
     530                535                540
Leu Asp Val Thr Thr His Leu Pro Ser Ala Ala Ser Gln Ile Pro Ala 
 545                550                555                560
Met Glu Glu Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe 
                 565                570                575
Lys Thr Arg Gln Gly Gln Val Ala Lys Gln Ser Cys Pro Ala Gly Thr 
             580                585                590
Ile Gly Val Ser Thr Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp 
         595                600                605
Pro Gln Gly Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His 
     610                615                620
Ile Thr Gln Lys Leu Lys Ser Gly Glu Thr Ala Ala Asn Ile Ala Arg 
 625                630                635                640
Glu Leu Ala Glu Gln Thr Arg Asn His Leu Asn Ala Gly Asp Ile Thr 
                 645                650                655
Tyr Ser Val Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln 
             660                665                670
Leu Arg Asn Leu Thr Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu 
         675                680                685
Asn Lys Leu Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala 
     690                695                700
Met Val Glu Thr Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala 
 705                710                715                720
Trp Arg Asp Leu Thr Thr Ser Asp Gln Leu Arg Ala Ala Thr Met Leu 
                 725                730                735
Leu Asp Thr Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu 
             740                745                750
Lys Thr Asp Ile Val Arg Glu Asn Thr Asp Asn Ile Gln Leu Glu Val 
         755                760                765
Ala Arg Leu Ser Thr Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu 
     770                775                780
Asn Thr Gly His Gly Ser Thr Ile Gln Leu Ser Ala Asn Thr Leu Lys 
 785                790                795                800
Gln Asn Gly Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn 
                 805                810                815
Asn Leu Gly Pro Tyr Leu Ser Thr Glu Asn Ala Ser Met Lys Leu Gly 
             820                825                830
Thr Glu Ala Met Ser Thr Asn His Ser Val Ile Val Asn Ser Pro Val 
         835                840                845
Ile Thr Ala Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala 
     850                855                860
Asp Pro Val Val Phe Thr Val Lys His Ile Lys Gln Ser Glu Glu Asn 
 865                870                875                880
Phe Asn Pro Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Thr Met Thr 
                 885                890                895
Gly Tyr Trp Ser Thr Gln Gly Cys Arg Leu Leu Thr Thr Asn Lys Thr 
             900                905                910
His Thr Thr Cys Ser Cys Asn His Leu Thr Asn Phe Ala Val Leu Met 
         915                920                925
Ala His Val Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu 
     930                935                940
Asp Val Ile Thr Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu 
 945                950                955                960
Ile Cys Ile Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg 
                 965                970                975
Asn Thr Ile His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu 
             980                985                990
Leu Phe Leu Ile Gly Ile Asn Arg Thr Asp Gln Pro Ile Ala Cys Ala 
         995                1000                1005
Val Phe Ala Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Thr Trp 
     1010                1015                1020
Met Phe Leu Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe 
 1025                1030                1035                1040
Glu Ser Glu His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly 
                 1045                1050                1055
Met Pro Ala Leu Ile Val Ala Val Ser Ala Ala Val Asp Tyr Arg Ser 
             1060                1065                1070
Tyr Gly Thr Asp Lys Val Cys Trp Leu Arg Leu Asp Thr Tyr Phe Ile 
         1075                1080                1085
Trp Ser Phe Ile Gly Pro Ala Thr Leu Ile Ile Met Leu Asn Val Ile 
     1090                1095                1100
Phe Leu Gly Ile Ala Leu Tyr Lys Met Phe His His Thr Ala Ile Leu 
 1105                1110                1115                1120
Lys Pro Glu Ser Gly Cys Leu Asp Asn Ile Asn Tyr Glu Asp Asn Arg 
                 1125                1130                1135
Pro Phe Ile Lys Ser Trp Val Ile Gly Ala Ile Ala Leu Leu Cys Leu 
             1140                1145                1150
Leu Gly Leu Thr Trp Ala Phe Gly Leu Met Tyr Ile Asn Glu Ser Thr 
         1155                1160                1165
Val Ile Met Ala Tyr Leu Phe Thr Ile Phe Asn Ser Leu Gln Gly Met 
     1170                1175                1180
Phe Ile Phe Ile Phe His Cys Val Leu Gln Lys Lys Val Arg Lys Glu 
 1185                1190                1195                1200
Tyr Gly Lys Cys Leu Arg Thr His Cys Cys Ser Gly Lys Ser Thr Glu 
                 1205                1210                1215
Ser Ser Ile Gly Ser Gly Lys Thr Ser Gly Ser Arg Thr Pro Gly Arg 
             1220                1225                1230
Tyr Ser Thr Gly Ser Gln Ser Arg Ile Arg Arg Met Trp Asn Asp Thr 
         1235                1240                1245
Val Arg Lys Gln Ser Glu Ser Ser Phe Ile Thr Gly Asp Ile Asn Ser 
     1250                1255                1260
Ser Ala Ser Leu Asn Arg Gly Ser Tyr Leu Pro Cys Ile Gln Ala Cys 
 1265                1270                1275                1280
Val Thr Tyr Leu Glu Gly Leu Leu Asn Asn Ala Arg Asp Thr Ser Val 
                 1285                1290                1295
Met Asp Thr Leu Pro Leu Asn Gly Asn His Gly Asn Ser Tyr Ser Ile 
             1300                1305                1310
Ala Gly Gly Glu Tyr Leu Ser Asn Cys Val Gln Ile Ile Asp Arg Gly 
         1315                1320                1325
Tyr Asn His Asn Glu Thr Ala Leu Glu Lys Lys Ile Leu Lys Glu Leu 
     1330                1335                1340
Thr Ser Asn Tyr Ile Pro Ser Tyr Leu Asn Asn His Glu Arg Ser Ser 
 1345                1350                1355                1360
Glu Gln Asn Arg Asn Met Met Asn Lys Leu Val Asp Asn Leu Gly Ser 
                 1365                1370                1375
Gly Ser Glu Asp Asp Ala Ile Val Leu Asp Asp Ala Ala Ser Phe Asn 
             1380                1385                1390
His Glu Glu Ser Leu Gly Leu Glu Leu Ile His Glu Glu Ser Asp Ala 
         1395                1400                1405
Pro Leu Leu Pro Pro Arg Val Tyr Ser Thr Asp Asn His Gln Pro His 
     1410                1415                1420
His Tyr Ser Arg Arg Arg Leu Pro Gln Asp His Ser Glu Ser Phe Phe 
 1425                1430                1435                1440
Pro Leu Leu Thr Asp Glu His Thr Glu Asp Pro Gln Ser Pro His Arg 
                 1445                1450                1455
Asp Ser Leu Tyr Thr Ser Met Pro Ala Leu Ala Gly Val Pro Ala Ala 
             1460                1465                1470
Asp Ser Val Thr Thr Ser Thr Gln Thr Glu Ala Ala Ala Ala Lys Gly 
         1475                1480                1485
Gly Asp Ala Glu Asp Val Tyr Tyr Lys Ser Met Pro Asn Leu Gly Ser 
     1490                1495                1500
Arg Asn His Val His Pro Leu His Ala Tyr Tyr Gln Leu Gly Arg Gly 
 1505                1510                1515                1520
Ser Ser Asp Gly Phe Ile Val Pro Pro Asn Lys Asp Gly Ala Ser Pro 
                 1525                1530                1535
Glu Gly Thr Ser Lys Gly Pro Ala His Leu Val Thr Ser Leu 
             1540                1545                1550



<210> 990
<211> 1511
<212> DNA
<213> Rattus norvegicus
<308> AF063447
<400> 990

tgggctcaa  gaaggaagc  ttgtagctc  cgtccaggg  cgcggcgtg  acgggtggc  60
ctcttcgca  ctcgcggag  cgaaccggg  aacagtgac  tggcagaac  ggatgtgga  120
aatgagctt  tggattatg  tgaagatga  gagccccag  taccccagg  gagcactcc  180
gctcccccg  agaaagatg  caaaggatc  tatgtctcc  tccacagtt  tggcttccg  240
gactttctg  tgaagccgg  gctcctgag  gctatagtt  actgtggct  tgaacatcc  300
tcagaggtc  agcatgaat  tattcccca  gccattctg  gtatggatg  cctgtgcca  360
gccaagtct  ggatgggca  gacagctgt  tttgtgctg  ccaccctgc  gcagattga  420
cccatcaat  gccaggtat  agtactggt  atgtgccac  caagggagc  ggccttcca  480
atcagcacg  agtatgagc  cttctcgaa  tacatgccc  gtgtcaagg  atctgtgtt  540
tttggaggc  tctccatta  gaaagatga  gatgtgtta  agaagaact  tccccatgt  600
gtggtgggg  caccaggcc  gatcctggc  ctcgtgcgg  gcaggagcc  caacctgag  660
aatgtgaag  actttgtgc  agatgaatg  gacaagatg  tggaacagc  ggacatgcg  720
cgggatgta  aggagatct  tcgtctgac  ccccatgag  agcaatgta  gatgttcag  780
gccaccctg  gcaaggaga  ccggccagt  tgcaggaag  tcatgcagg  tcctatgga  840
gtgtttgtg  acgacgaga  caagctcac  ctgcatggg  tgcagcagt  ttacgtcaa  900
ctcaaggac  gtgagaaga  tcgtaaact  ttcgacctc  ttgacgtgc  agagtttaa  960
caggtggtg  tctttgtca  gtctgtgca  cgctgcatg  ccctggccc  gctcctagt  1020
gaacagaat  ttccggcta  cgctattca  agaggcatg  cccaggagg  gcgcctgtc  1080
cgataccag  agttcaagg  cttccagcg  cgcatccta  tggctacta  tctgtttgg  1140
agaggcatg  acattgaga  agtcaacat  gtcttcaac  atgacatgc  agaggactc  1200
gatacctac  tgcaccgag  ggctcgtgc  ggtcgcttt  gtaccaagg  tctggcagt  1260
acttttgtg  cagatgaga  tgatgccaa  atccttaat  acgttcagg  ccggtttga  1320
gtgaatgtg  ctgagcttc  agaagaaat  gatatctcc  catacattg  gcagagccg  1380
taaccatgt  tgtagccag  cacatggct  tctctcctg  tgcttcaga  cctcctcct  1440
ggtggcaat  ggcggcctc  ctttttatt  ttccaaagc  ttagctatg  taagaataa  1500
cttttattg  g  1511



<210> 991
<211> 427
<212> PRT
<213> Rattus norvegicus
<308> AAC16391
<400> 991

Met Ala Glu Gln Asp Val Glu Asn Glu Leu Leu Asp Tyr Asp Glu Asp 
  1               5                  10                  15
Glu Glu Pro Gln Val Pro Gln Glu Ser Thr Pro Ala Pro Pro Lys Lys 
             20                  25                  30
Asp Val Lys Gly Ser Tyr Val Ser Ile His Ser Ser Gly Phe Arg Asp 
         35                  40                  45
Phe Leu Leu Lys Pro Glu Leu Leu Arg Ala Ile Val Asp Cys Gly Phe 
     50                  55                  60
Glu His Pro Ser Glu Val Gln His Glu Cys Ile Pro Gln Ala Ile Leu 
 65                  70                  75                  80
Gly Met Asp Val Leu Cys Gln Ala Lys Ser Gly Met Gly Lys Thr Ala 
                 85                  90                  95
Val Phe Val Leu Ala Thr Leu Gln Gln Ile Glu Pro Ile Asn Gly Gln 
             100                105                110
Val Ser Val Leu Val Met Cys His Thr Arg Glu Leu Ala Phe Gln Ile 
         115                120                125
Ser Thr Glu Tyr Glu Arg Phe Ser Lys Tyr Met Pro Ser Val Lys Val 
     130                135                140
Ser Val Phe Phe Gly Gly Leu Ser Ile Lys Lys Asp Glu Asp Val Leu 
 145                150                155                160
Lys Lys Asn Cys Pro His Val Val Val Gly Thr Pro Gly Arg Ile Leu 
                 165                170                175
Ala Leu Val Arg Ser Arg Ser Leu Asn Leu Arg Asn Val Lys His Phe 
             180                185                190
Val Leu Asp Glu Cys Asp Lys Met Leu Glu Gln Leu Asp Met Arg Arg 
         195                200                205
Asp Val Gln Glu Ile Phe Arg Leu Thr Pro His Glu Lys Gln Cys Met 
     210                215                220
Met Phe Ser Ala Thr Leu Ser Lys Glu Ile Arg Pro Val Cys Arg Lys 
 225                230                235                240
Phe Met Gln Asp Pro Met Glu Val Phe Val Asp Asp Glu Thr Lys Leu 
                 245                250                255
Thr Leu His Gly Leu Gln Gln Tyr Tyr Val Lys Leu Lys Asp Ser Glu 
             260                265                270
Lys Asn Arg Lys Leu Phe Asp Leu Leu Asp Val Leu Glu Phe Asn Gln 
         275                280                285
Val Val Ile Phe Val Lys Ser Val Gln Arg Cys Met Ala Leu Ala Gln 
     290                295                300
Leu Leu Val Glu Gln Asn Phe Pro Ala Ile Ala Ile His Arg Gly Met 
 305                310                315                320
Ala Gln Glu Glu Arg Leu Ser Arg Tyr Gln Gln Phe Lys Asp Phe Gln 
                 325                330                335
Arg Arg Ile Leu Val Ala Thr Asn Leu Phe Gly Arg Gly Met Asp Ile 
             340                345                350
Glu Arg Val Asn Ile Val Phe Asn Tyr Asp Met Pro Glu Asp Ser Asp 
         355                360                365
Thr Tyr Leu His Arg Val Ala Arg Ala Gly Arg Phe Gly Thr Lys Gly 
     370                375                380
Leu Ala Val Thr Phe Val Ser Asp Glu Asn Asp Ala Lys Ile Leu Asn 
 385                390                395                400
Asp Val Gln Asp Arg Phe Glu Val Asn Val Ala Glu Leu Pro Glu Glu 
                 405                410                415
Ile Asp Ile Ser Thr Tyr Ile Glu Gln Ser Arg 
             420                425



<210> 992
<211> 1504
<212> DNA
<213> Homo sapiens
<308> BC001009
<400> 992

ggcacgagg  cgaagttgg  agtgtctct  agcagcgcg  ggagaagaa  ggggagcca  60
catcatggc  gaacaggat  tggaaaacg  tcttttgga  tacgatgaa  aggaagagc  120
ccaggctcc  caagagagc  caccagctc  ccctaagaa  gacatcaag  gatcctacg  180
ttccatcca  agctctggc  tccgggact  tctgctgaa  ccggagctc  tgcgggcca  240
cgtggactg  ggctttgag  atccttctg  ggtccagca  gagtgcatt  cccaggcca  300
cctgggcat  gacgtcctg  gccaggcca  gtccgggat  ggcaagaca  cggtcttcg  360
gctggccac  ctacagcag  ttgagcctg  caacggaca  gtgacggtc  tggtcatgt  420
ccacacgag  gagctggcc  tccagatca  caaggaata  gagcgcttt  ccaagtaca  480
gcccagcgt  aaggtgtct  tgttcttcg  tggtctctc  atcaagaag  atgaagaag  540
gttgaagaa  aactgtccc  atgtcgtgg  ggggacccc  ggccgcatc  tggcgctcg  600
gcggaatag  agcttcagc  taaagaatg  gaagcactt  gtgctggac  agtgtgaca  660
gatgctgga  cagctggac  tgcggcggg  tgtgcagga  atcttccgc  tgacaccac  720
cgagaagca  tgcatgatg  tcagcgcca  cctgagcaa  gacatccgg  ctgtgtgca  780
gaagttcat  caggatccc  tggaggtgt  tgtggacga  gagaccaag  tcacgctgc  840
cggcctgca  cagtactac  tcaaactca  agacagtga  aagaaccgc  agctctttg  900
tctcttgga  gtgctggag  ttaaccagg  gataatctt  gtcaagtca  tgcagcgct  960
catggccct  gcccagctc  tcgtggagc  gaacttccc  gccatcgcc  tccaccggg  1020
catggccca  gaggagcgc  tgtcacgct  tcagcagtt  aaggatttc  agcggcgga  1080
cctggtggc  accaatctg  ttggccggg  gatggacat  gagcgagtc  acatcgtct  1140
taactacga  atgcctgag  actcggaca  ctacctgca  cgggtggcc  gggcgggtc  1200
ctttggcac  aaaggccta  ccatcactt  tgtgtctga  gagaatgat  ccaaaatcc  1260
caatgacgt  caggaccgg  ttgaagtta  tgtggcaga  cttccagag  aaatcgaca  1320
ctccacata  atcgagcag  gccggtaac  accacgtgc  agagccgcc  acccggagc  1380
gcccgcatg  agcttcacc  cccctttcc  ggcgccact  ttgagaagc  agagattgt  1440
tgagaataa  cttgttatt  tggaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1500
aaaa  1504



<210> 993
<211> 427
<212> PRT
<213> Homo sapiens
<308> AAH01009
<400> 993

Met Ala Glu Gln Asp Val Glu Asn Asp Leu Leu Asp Tyr Asp Glu Glu 
  1               5                  10                  15
Glu Glu Pro Gln Ala Pro Gln Glu Ser Thr Pro Ala Pro Pro Lys Lys 
             20                  25                  30
Asp Ile Lys Gly Ser Tyr Val Ser Ile His Ser Ser Gly Phe Arg Asp 
         35                  40                  45
Phe Leu Leu Lys Pro Glu Leu Leu Arg Ala Ile Val Asp Cys Gly Phe 
     50                  55                  60
Glu His Pro Ser Glu Val Gln His Glu Cys Ile Pro Gln Ala Ile Leu 
 65                  70                  75                  80
Gly Met Asp Val Leu Cys Gln Ala Lys Ser Gly Met Gly Lys Thr Ala 
                 85                  90                  95
Val Phe Val Leu Ala Thr Leu Gln Gln Ile Glu Pro Val Asn Gly Gln 
             100                105                110
Val Thr Val Leu Val Met Cys His Thr Arg Glu Leu Ala Phe Gln Ile 
         115                120                125
Ser Lys Glu Tyr Glu Arg Phe Ser Lys Tyr Met Pro Ser Val Lys Val 
     130                135                140
Ser Val Phe Phe Gly Gly Leu Ser Ile Lys Lys Asp Glu Glu Val Leu 
 145                150                155                160
Lys Lys Asn Cys Pro His Val Val Val Gly Thr Pro Gly Arg Ile Leu 
                 165                170                175
Ala Leu Val Arg Asn Arg Ser Phe Ser Leu Lys Asn Val Lys His Phe 
             180                185                190
Val Leu Asp Glu Cys Asp Lys Met Leu Glu Gln Leu Asp Met Arg Arg 
         195                200                205
Asp Val Gln Glu Ile Phe Arg Leu Thr Pro His Glu Lys Gln Cys Met 
     210                215                220
Met Phe Ser Ala Thr Leu Ser Lys Asp Ile Arg Pro Val Cys Arg Lys 
 225                230                235                240
Phe Met Gln Asp Pro Met Glu Val Phe Val Asp Asp Glu Thr Lys Leu 
                 245                250                255
Thr Leu His Gly Leu Gln Gln Tyr Tyr Val Lys Leu Lys Asp Ser Glu 
             260                265                270
Lys Asn Arg Lys Leu Phe Asp Leu Leu Asp Val Leu Glu Phe Asn Gln 
         275                280                285
Val Ile Ile Phe Val Lys Ser Val Gln Arg Cys Met Ala Leu Ala Gln 
     290                295                300
Leu Leu Val Glu Gln Asn Phe Pro Ala Ile Ala Ile His Arg Gly Met 
 305                310                315                320
Ala Gln Glu Glu Arg Leu Ser Arg Tyr Gln Gln Phe Lys Asp Phe Gln 
                 325                330                335
Arg Arg Ile Leu Val Ala Thr Asn Leu Phe Gly Arg Gly Met Asp Ile 
             340                345                350
Glu Arg Val Asn Ile Val Phe Asn Tyr Asp Met Pro Glu Asp Ser Asp 
         355                360                365
Thr Tyr Leu His Arg Val Ala Arg Ala Gly Arg Phe Gly Thr Lys Gly 
     370                375                380
Leu Ala Ile Thr Phe Val Ser Asp Glu Asn Asp Ala Lys Ile Leu Asn 
 385                390                395                400
Asp Val Gln Asp Arg Phe Glu Val Asn Val Ala Glu Leu Pro Glu Glu 
                 405                410                415
Ile Asp Ile Ser Thr Tyr Ile Glu Gln Ser Arg 
             420                425



<210> 994
<211> 623
<212> DNA
<213> Rattus norvegicus
<308> AF064541
<400> 994

ctccctgaa  ttctaacta  gaattctga  ccttcttgg  ctgccaccc  ctcccctgg  60
ggcaccctg  ctgtcccca  tgctaccac  ccgtggcta  gtagggatg  agagctagc  120
aaggtggag  tcggtatcc  agctactgt  ctggttctg  ccacaggag  caacctggc  180
gtacttctg  ctctgggcc  ccatggcca  aagccgtcc  gcatgcatc  gttcgtgct  240
cacttggcc  tgaccgacc  gggcgtggc  cttttccag  ttctaccaa  gtggctttc  300
ccatctcca  gcttctggg  aacctcagc  gctgctgca  cccctggat  tacatgggc  360
tcaacagtc  cctgttgcc  cgttccttg  gccaccatg  ctgctgcac  ggctctaag  420
cccaagtgc  caggcaact  tccaccagc  gcctcacta  ccgtcgcac  acgctgctg  480
cccatgcct  tggttcccc  actctccga  tcagcctta  cctcagcct  cgtgcaaag  540
ccagacctg  aggctcact  aaggattta  agcaggtgg  cggggaagc  actatggag  600
ccagcatct  ttagagaag  ttc  623



<210> 995
<211> 425
<212> PRT
<213> Rattus norvegicus
<308> P48974
<400> 995

Met Asn Ser Glu Pro Ser Trp Thr Ala Thr Pro Ser Pro Gly Gly Thr 
  1               5                  10                  15
Leu Pro Val Pro Asn Ala Thr Thr Pro Trp Leu Gly Arg Asp Glu Glu 
             20                  25                  30
Leu Ala Lys Val Glu Ile Gly Ile Leu Ala Thr Val Leu Val Leu Ala 
         35                  40                  45
Thr Gly Gly Asn Leu Ala Val Leu Leu Thr Leu Gly Arg His Gly His 
     50                  55                  60
Lys Arg Ser Arg Met His Leu Phe Val Leu His Leu Ala Leu Thr Asp 
 65                  70                  75                  80
Leu Gly Val Ala Leu Phe Gln Val Leu Pro Gln Leu Leu Trp Asp Ile 
                 85                  90                  95
Thr Tyr Arg Phe Gln Gly Ser Asp Leu Leu Cys Arg Ala Val Lys Tyr 
             100                105                110
Leu Gln Val Leu Ser Met Phe Ala Ser Thr Tyr Met Leu Leu Ala Met 
         115                120                125
Thr Leu Asp Arg Tyr Leu Ala Val Cys His Pro Leu Arg Ser Leu Arg 
     130                135                140
Gln Pro Ser Gln Ser Thr Tyr Pro Leu Ile Ala Ala Pro Trp Leu Leu 
 145                150                155                160
Ala Ala Ile Leu Ser Leu Pro Gln Val Phe Ile Phe Ser Leu Arg Glu 
                 165                170                175
Val Ile Gln Gly Ser Gly Val Leu Asp Cys Trp Ala Asp Phe Tyr Phe 
             180                185                190
Ser Trp Gly Pro Arg Ala Tyr Ile Thr Trp Thr Thr Met Ala Ile Phe 
         195                200                205
Val Leu Pro Val Ala Val Leu Ser Ala Cys Tyr Gly Leu Ile Cys His 
     210                215                220
Glu Ile Tyr Lys Asn Leu Lys Val Lys Thr Gln Ala Gly Arg Glu Glu 
 225                230                235                240
Arg Arg Gly Trp Arg Thr Trp Asp Lys Ser Ser Ser Ser Ala Val Ala 
                 245                250                255
Thr Ala Ala Thr Arg Gly Leu Pro Ser Arg Val Ser Ser Ile Ser Thr 
             260                265                270
Ile Ser Arg Ala Lys Ile Arg Thr Val Lys Met Thr Phe Val Ile Val 
         275                280                285
Leu Ala Tyr Ile Ala Cys Trp Ala Pro Phe Phe Ser Val Gln Met Trp 
     290                295                300
Ser Val Trp Asp Glu Asn Ala Pro Asn Glu Asp Ser Thr Asn Val Ala 
 305                310                315                320
Phe Thr Ile Ser Met Leu Leu Gly Asn Leu Ser Ser Cys Cys Asn Pro 
                 325                330                335
Trp Ile Tyr Met Gly Phe Asn Ser Arg Leu Leu Pro Arg Ser Leu Ser 
             340                345                350
His His Ala Cys Cys Thr Gly Ser Lys Pro Gln Val His Arg Gln Leu 
         355                360                365
Ser Thr Ser Ser Leu Thr Ser Arg Arg Thr Thr Leu Leu Thr His Ala 
     370                375                380
Cys Gly Ser Pro Thr Leu Arg Leu Ser Leu Asn Leu Ser Leu Arg Ala 
 385                390                395                400
Lys Pro Arg Pro Ala Gly Ser Leu Lys Asp Leu Glu Gln Val Asp Gly 
                 405                410                415
Glu Ala Thr Met Glu Thr Ser Ile Phe 
             420                425



<210> 996
<211> 1869
<212> DNA
<213> Homo sapiens
<308> L37112
<400> 996

tctccacct  ccctgccac  ccattttat  catcaaacc  ctccacttg  atccacacc  60
tcccttcat  cttccctcc  agcaaacct  gctcatgga  tctgggcct  tgtgggatg  120
caaccccac  cctcggggc  ccctctctg  ccccaatgc  acaacaccc  ggctgggcc  180
ggatgagga  ctggccaag  tggagatcg  agtcctggc  actgtcctg  tgctggcga  240
cgggggcaa  ctggctgtg  tgctgaccc  gggccagct  ggccgcaag  gctcccgca  300
gcacctgtt  gtgctgcac  tagccctga  agacctggc  gtggcgctc  tccaggtgc  360
gccacagct  ctgtgggac  tcacctacc  cttccaggg  cccgacctc  tgtgcaggg  420
cgtcaagta  ctgcaggtg  tcagcatgt  tgcctccac  tacatgctg  tggccatga  480
gctggaccg  tacctggct  tctgtcacc  cctgcgcag  ctccagcag  caggccagt  540
cacctacct  ctcatcgct  ctccctggc  gctggccgc  atcttcagc  tccctcaag  600
cttcatttt  tccctgcgg  aggtgatcc  gggctcagg  gtgctggac  gctgggcag  660
cttcggctt  ccttggggg  cacgggcct  cctcacctg  accaccctg  ctatcttcg  720
tctgccggt  accatgctc  cggcctgct  cagcctcat  tgccacgag  tctgtaaaa  780
cctaaaagt  aagacacag  cctggcggg  gggaggagg  ggctggagg  cttgggaca  840
gccctcacc  tccacctta  ctgccacca  tcgggggct  ccatctcgg  tcagcagca  900
caacaccat  tcacgggcc  agatccgaa  agtgaagat  acctttgtc  tcgtgctgg  960
ctacatcgc  tgctgggct  ccttcttca  tgtccagat  tggtccgtg  gggacaaga  1020
tgcccctga  gaagattcc  ccaatgtgg  tttcaccat  tctatgctt  tgggcaacc  1080
caacagctg  tgcaacccc  ggatctaca  gggcttcaa  agccacctg  taccgcggc  1140
cctgcgtca  cttgcctgc  gtgggggtc  ccagcccag  atgcgccgg  ggctctccg  1200
cggcagcct  tcaagccgc  acaccacgc  gctgacccg  tccagctgc  cggccaccc  1260
cagcctcag  ctcagccta  ccctcagtg  gaggcccag  cctgaagag  caccaaggg  1320
cttggagct  gcagatggg  aaggcaccg  tgagaccat  atcttttag  aagactcgc  1380
ggggtctgg  actgccccc  ggactagtg  aggttctct  cccacctca  gcactggaa  1440
tgagagctg  gagggtaag  gttggagtt  gaggaggcc  tgtctgaag  agagccaaa  1500
ggccagaat  ggtccccta  cctggtgtc  cagctgccc  tagtgtgag  gctgcctca  1560
aagctccca  tctcagaca  tggcagtca  ggagaatca  actgcctgt  tccctggtc  1620
tgccatatt  atagggtgt  cathcacac  tggtgtccc  gatctaggc  ggcctagga  1680
ggtgctgtc  aggggtcca  gggtggcag  aattcagag  ctggccttg  gccctggct  1740
cctgtctcc  ttctaacct  actggcaca  ctcagccta  ccaggagag  ggagaagtg  1800
aaaaccgtg  ggaggactc  atttggatc  tggatttgt  gttgttgtt  ttgttgttg  1860
tagagagaa  1869



<210> 997
<211> 424
<212> PRT
<213> Homo sapiens
<308> P47901
<400> 997

Met Asp Ser Gly Pro Leu Trp Asp Ala Asn Pro Thr Pro Arg Gly Thr 
  1               5                  10                  15
Leu Ser Ala Pro Asn Ala Thr Thr Pro Trp Leu Gly Arg Asp Glu Glu 
             20                  25                  30
Leu Ala Lys Val Glu Ile Gly Val Leu Ala Thr Val Leu Val Leu Ala 
         35                  40                  45
Thr Gly Gly Asn Leu Ala Val Leu Leu Thr Leu Gly Gln Leu Gly Arg 
     50                  55                  60
Lys Arg Ser Arg Met His Leu Phe Val Leu His Leu Ala Leu Thr Asp 
 65                  70                  75                  80
Leu Ala Val Ala Leu Phe Gln Val Leu Pro Gln Leu Leu Trp Asp Ile 
                 85                  90                  95
Thr Tyr Arg Phe Gln Gly Pro Asp Leu Leu Cys Arg Ala Val Lys Tyr 
             100                105                110
Leu Gln Val Leu Ser Met Phe Ala Ser Thr Tyr Met Leu Leu Ala Met 
         115                120                125
Thr Leu Asp Arg Tyr Leu Ala Val Cys His Pro Leu Arg Ser Leu Gln 
     130                135                140
Gln Pro Gly Gln Ser Thr Tyr Leu Leu Ile Ala Ala Pro Trp Leu Leu 
 145                150                155                160
Ala Ala Ile Phe Ser Leu Pro Gln Val Phe Ile Phe Ser Leu Arg Glu 
                 165                170                175
Val Ile Gln Gly Ser Gly Val Leu Asp Cys Trp Ala Asp Phe Gly Phe 
             180                185                190
Pro Trp Gly Pro Arg Ala Tyr Leu Thr Trp Thr Thr Leu Ala Ile Phe 
         195                200                205
Val Leu Pro Val Thr Met Leu Thr Ala Cys Tyr Ser Leu Ile Cys His 
     210                215                220
Glu Ile Cys Lys Asn Leu Lys Val Lys Thr Gln Ala Trp Arg Val Gly 
 225                230                235                240
Gly Gly Gly Trp Arg Thr Trp Asp Arg Pro Ser Pro Ser Thr Leu Ala 
                 245                250                255
Ala Thr Thr Arg Gly Leu Pro Ser Arg Val Ser Ser Ile Asn Thr Ile 
             260                265                270
Ser Arg Ala Lys Ile Arg Thr Val Lys Met Thr Phe Val Ile Val Leu 
         275                280                285
Ala Tyr Ile Ala Cys Trp Ala Pro Phe Phe Ser Val Gln Met Trp Ser 
     290                295                300
Val Trp Asp Lys Asn Ala Pro Asp Glu Asp Ser Thr Asn Val Ala Phe 
 305                310                315                320
Thr Ile Ser Met Leu Leu Gly Asn Leu Asn Ser Cys Cys Asn Pro Trp 
                 325                330                335
Ile Tyr Met Gly Phe Asn Ser His Leu Leu Pro Arg Pro Leu Arg His 
             340                345                350
Leu Ala Cys Cys Gly Gly Pro Gln Pro Arg Met Arg Arg Arg Leu Ser 
         355                360                365
Asp Gly Ser Leu Ser Ser Arg His Thr Thr Leu Leu Thr Arg Ser Ser 
     370                375                380
Cys Pro Ala Thr Leu Ser Leu Ser Leu Ser Leu Thr Leu Ser Gly Arg 
 385                390                395                400
Pro Arg Pro Glu Glu Ser Pro Arg Asp Leu Glu Leu Ala Asp Gly Glu 
                 405                410                415
Gly Thr Ala Glu Thr Ile Ile Phe 
             420



<210> 999
<211> 611
<212> PRT
<213> Rattus norvegicus
<308> AAC63267
<400> 999

Met Trp Thr Gly Gly Arg Arg Pro Gly Arg Leu Arg Arg Ala Ala Ser 
  1               5                  10                  15
Ala Ala Asp Met Glu Lys Leu Ser Ala Leu Gln Glu Gln Lys Gly Glu 
             20                  25                  30
Leu Arg Lys Arg Leu Ser Tyr Thr Thr His Lys Leu Glu Lys Leu Glu 
         35                  40                  45
Thr Glu Phe Asp Ser Thr Arg His Tyr Leu Glu Ile Glu Leu Arg Arg 
     50                  55                  60
Ala Gln Glu Glu Leu Asp Lys Val Thr Glu Lys Leu Arg Arg Ile Gln 
 65                  70                  75                  80
Ser Asn Tyr Met Ala Leu Gln Arg Ile Asn Gln Glu Leu Glu Asp Lys 
                 85                  90                  95
Leu Tyr Arg Met Gly Gln His Tyr Glu Glu Glu Lys Arg Ala Met Ser 
             100                105                110
His Glu Ile Val Ala Leu Asn Ser His Leu Leu Glu Ala Lys Val Thr 
         115                120                125
Ile Asp Lys Leu Ser Glu Asp Asn Glu Leu Tyr Arg Lys Asp Cys Asn 
     130                135                140
Leu Ala Ala Gln Leu Leu Gln Cys Ser Gln Thr Tyr Gly Arg Val His 
 145                150                155                160
Lys Val Ser Glu Leu Pro Ser Asp Phe Gln Gln Arg Val Ser Leu His 
                 165                170                175
Met Glu Lys His Gly Cys Ser Leu Pro Ser Pro Leu Cys His Pro Ser 
             180                185                190
Tyr Ala Asp Ser Val Pro Thr Cys Val Ile Ala Lys Val Leu Glu Lys 
         195                200                205
Pro Asp Pro Gly Ser Leu Ser Ser Arg Met Ser Asp Ala Ser Ala Arg 
     210                215                220
Asp Leu Ala Tyr Arg Asp Gly Val Glu Asn Pro Gly Pro Arg Pro Pro 
 225                230                235                240
Tyr Lys Gly Asp Ile Tyr Cys Ser Asp Thr Ala Leu Tyr Cys Pro Asp 
                 245                250                255
Glu Arg Asp His Asp Arg Arg Pro Ser Val Asp Thr Pro Val Thr Asp 
             260                265                270
Val Gly Phe Leu Arg Ala Gln Asn Ser Thr Asp Ser Leu Ala Glu Glu 
         275                280                285
Glu Glu Ala Glu Ala Ala Ala Phe Pro Glu Ala Tyr Arg Arg Glu Ala 
     290                295                300
Phe Gln Gly Tyr Ala Ala Ser Leu Pro Thr Ser Ser Ser Tyr Ser Ser 
 305                310                315                320
Phe Ser Ala Thr Ser Glu Glu Lys Glu His Ala Gln Ala Ser Thr Leu 
                 325                330                335
Thr Ala Ser Gln Gln Ala Ile Tyr Leu Asn Ser Arg Glu Glu Leu Phe 
             340                345                350
Ser Arg Lys Pro Pro Ser Ala Thr Tyr Gly Ser Ser Pro Arg Tyr Ala 
         355                360                365
Lys Ala Ala Ala Thr Leu Gly Ser Pro Leu Glu Ala Gln Val Ala Pro 
     370                375                380
Gly Phe Ala Arg Thr Val Ser Pro Tyr Pro Ala Glu Pro Tyr Arg Tyr 
 385                390                395                400
Pro Ala Ser Gln Gln Ala Leu Met Pro Pro Asn Leu Trp Ser Leu Arg 
                 405                410                415
Ala Lys Pro Ser Gly Asn Arg Leu Ala Ala Arg Glu Asp Ile Arg Gly 
             420                425                430
Gln Trp Arg Pro Leu Ser Val Glu Asp Val Gly Ala Tyr Ser Tyr Gln 
         435                440                445
Ala Gly Ala Ala Gly Arg Ala Ala Ser Pro Cys Asn Phe Ser Glu Arg 
     450                455                460
Phe Tyr Gly Gly Gly Gly Gly Gly Gly Ser Pro Gly Lys Asn Ala Glu 
 465                470                475                480
Gly Arg Ala Ser Pro Leu Tyr Ala Ser Tyr Lys Ala Asp Ser Phe Ser 
                 485                490                495
Glu Gly Asp Asp Leu Ser Gln Gly His Leu Ala Glu Pro Cys Phe Leu 
             500                505                510
Arg Ala Gly Gly Asp Leu Ser Leu Ser Pro Ser Arg Ser Ala Asp Pro 
         515                520                525
Leu Pro Gly Tyr Ala Thr Ser Asp Gly Asp Gly Asp Arg Leu Gly Val 
     530                535                540
Gln Leu Cys Gly Pro Gly Ser Ser Pro Glu Pro Glu His Gly Ser Arg 
 545                550                555                560
Asp Ser Leu Glu Pro Ser Ser Met Glu Ala Ser Pro Glu Met His Pro 
                 565                570                575
Pro Thr Arg Leu Ser Pro Gln Gln Ala Phe Pro Arg Thr Gly Gly Ser 
             580                585                590
Gly Leu Ser Arg Lys Asp Ser Leu Thr Lys Ala Gln Leu Tyr Gly Thr 
         595                600                605
Leu Leu Asn 
     610



<210> 1001
<211> 593
<212> PRT
<213> Homo sapiens
<308> NP_065887
<400> 1001

Met Glu Lys Leu Ser Ala Leu Gln Glu Gln Lys Gly Glu Leu Arg Lys 
  1               5                  10                  15
Arg Leu Ser Tyr Thr Thr His Lys Leu Glu Lys Leu Glu Thr Glu Phe 
             20                  25                  30
Asp Ser Thr Arg His Tyr Leu Glu Ile Glu Leu Arg Arg Ala Gln Glu 
         35                  40                  45
Glu Leu Glu Lys Val Thr Glu Lys Leu Arg Arg Ile Gln Ser Asn Tyr 
     50                  55                  60
Met Ala Leu Gln Arg Ile Asn Gln Glu Leu Glu Asp Lys Leu Tyr Arg 
 65                  70                  75                  80
Met Gly Gln His Tyr Glu Glu Glu Lys Arg Ala Leu Ser His Glu Ile 
                 85                  90                  95
Val Ala Leu Asn Ser His Leu Leu Glu Ala Lys Val Thr Ile Asp Lys 
             100                105                110
Leu Ser Glu Asp Asn Glu Leu Tyr Arg Lys Asp Cys Asn Leu Ala Ala 
         115                120                125
Gln Leu Leu Gln Cys Ser Gln Thr Tyr Gly Arg Val His Lys Val Ser 
     130                135                140
Glu Leu Pro Ser Asp Phe Gln Glu Arg Val Ser Leu His Met Glu Lys 
 145                150                155                160
His Gly Cys Ser Leu Pro Ser Pro Leu Cys His Pro Ala Tyr Ala Asp 
                 165                170                175
Ser Val Pro Thr Cys Val Ile Ala Lys Val Leu Glu Lys Pro Asp Pro 
             180                185                190
Ala Ser Leu Ser Ser Arg Leu Ser Asp Ala Ser Ala Arg Asp Leu Ala 
         195                200                205
Phe Cys Asp Gly Val Glu Lys Pro Gly Pro Arg Pro Pro Tyr Lys Gly 
     210                215                220
Asp Ile Tyr Cys Ser Asp Thr Ala Leu Tyr Cys Pro Glu Glu Arg Arg 
 225                230                235                240
Arg Asp Arg Arg Pro Ser Val Asp Ala Pro Val Thr Asp Val Gly Phe 
                 245                250                255
Leu Arg Ala Gln Asn Ser Thr Asp Ser Ala Ala Glu Glu Glu Glu Glu 
             260                265                270
Ala Glu Ala Ala Ala Phe Pro Ala Gly Phe Gln His Glu Ala Phe Pro 
         275                280                285
Ser Tyr Ala Gly Ser Leu Pro Thr Ser Ser Ser Tyr Ser Ser Phe Ser 
     290                295                300
Ala Thr Ser Glu Glu Lys Glu His Ala Gln Ala Ser Thr Leu Thr Ala 
 305                310                315                320
Ser Gln Gln Ala Ile Tyr Leu Asn Ser Arg Asp Glu Leu Phe Asp Arg 
                 325                330                335
Lys Pro Pro Ala Thr Thr Tyr Glu Gly Ser Pro Arg Phe Ala Lys Ala 
             340                345                350
Thr Ala Ala Val Ala Ala Pro Leu Glu Ala Glu Val Ala Pro Gly Phe 
         355                360                365
Gly Arg Thr Met Ser Pro Tyr Pro Ala Glu Thr Phe Arg Phe Pro Ala 
     370                375                380
Ser Pro Gly Pro Gln Gln Ala Leu Met Pro Pro Asn Leu Trp Ser Leu 
 385                390                395                400
Arg Ala Lys Pro Gly Thr Ala Arg Leu Pro Gly Glu Asp Met Arg Gly 
                 405                410                415
Gln Trp Arg Pro Leu Ser Val Glu Asp Ile Gly Ala Tyr Ser Tyr Pro 
             420                425                430
Val Ser Ala Ala Gly Arg Ala Ser Pro Cys Ser Phe Ser Glu Arg Tyr 
         435                440                445
Tyr Gly Gly Ala Gly Gly Ser Pro Gly Lys Lys Ala Asp Gly Arg Ala 
     450                455                460
Ser Pro Leu Tyr Ala Ser Tyr Lys Ala Asp Ser Phe Ser Glu Gly Asp 
 465                470                475                480
Asp Leu Ser Gln Gly His Leu Ala Glu Pro Cys Phe Leu Arg Ala Gly 
                 485                490                495
Gly Asp Leu Ser Leu Ser Pro Gly Arg Ser Ala Asp Pro Leu Pro Gly 
             500                505                510
Tyr Ala Pro Ser Glu Gly Gly Asp Gly Asp Arg Leu Gly Val Gln Leu 
         515                520                525
Cys Gly Thr Ala Ser Ser Pro Glu Pro Glu Gln Gly Ser Arg Asp Ser 
     530                535                540
Leu Glu Pro Ser Ser Met Glu Ala Ser Pro Glu Met His Pro Ala Ala 
 545                550                555                560
Arg Leu Ser Pro Gln Gln Ala Phe Pro Arg Thr Gly Gly Ser Gly Leu 
                 565                570                575
Ser Arg Lys Asp Ser Leu Thr Lys Ala Gln Leu Tyr Gly Thr Leu Leu 
             580                585                590
Asn 
         595



<210> 1002
<211> 2754
<212> DNA
<213> Rattus norvegicus
<308> AF065387
<400> 1002

aaaaaaaaa  aaaaagacagcaa  tctaagtct  gaggttcca  tgattcgga  ctggctgca  agaggttca  60
ctattccct  cagtcatgg  tgtccaccg  ggctctgca  gagctgctc  cgcctcaga  120
aaagtacag  aaaacaagc  tgcacagac  tcggggctg  aacagggca  ccgaatggc  180
agaattttt  ggtttgaat  ggcagattt  tccagctgg  agagtgtcg  gaccctact  240
aaccgacca  cggaccctg  aaacctggc  gtcttccgt  ttctctttg  attcttgat  300
ctgctggac  tcccccagg  acggggcct  agctccctg  accgaaaat  cttggatgg  360
ctggatgtg  gccgcttcc  cttgctgga  gccttgcgc  cactgccac  tgactggat  420
tatctcgtc  acaccatca  gtttctggg  gcactgggc  tgatgctgg  cctgtggta  480
cggctaagc  gtatgttat  cctgctacc  tactggtac  tgtttctcc  ggacaagac  540
tcgtggaac  atcactcct  tctgtatgg  ttgttggcc  ttcagttga  attcatgga  600
gcaaaccac  actggtctg  ggatggcct  ctgagtgcc  aaaagaaga  tgctcacgt  660
cccctttgg  actacacag  cctgcgtgg  cagatcttc  ttgtgtatt  cattgcggg  720
gtgaaaaag  tggatgctg  ctgggttga  ggctactcc  tggagcatt  gtcccggca  780
tggcttttt  gtcccttca  gctagtgtt  tcggaggag  tgacaagcc  gctggtggt  840
cactggtgt  ggcttctcc  tgacctctc  gctggcttc  tgctcttct  cgatgcctc  900
agacccatt  gcctcgtct  cgtgtccta  tttcactgc  tgaactcgc  gctcttcag  960
ataggtatg  tcccctatg  catgctggc  agcagccct  tcttctgct  agctgaatg  1020
cctcggaag  tggtagccc  atgcccgaa  aggctgcaa  agctgctgc  tgccaaagc  1080
gctcctcgg  ctagtgctt  ctgtgtgta  aagagggcc  gggcgaaag  tggtcaaaa  1140
ccaggccta  gccaccatc  gggaactgt  ttcaccctg  tctaccttc  ggagcagct  1200
ttcctgccc  attcccatt  cctcacgca  ggttacaac  actggacga  tgggctgta  1260
ggctattcc  gggacatga  ggtgcactc  cgctcccac  agcatgtaa  gatcaccta  1320
cgtgatggc  tcactggag  gctgggcta  cttaaccct  gggtattca  acagagccg  1380
cgctggaag  accatgcag  catgctgaa  caatatgcc  cttgcctga  cctcctgct  1440
cccaagtac  atgtcactg  gccccagat  tactttgat  tctgggtct  catcaatga  1500
cgcttccag  agaggcttt  tgaccctcg  gtggacatc  tgcaggccg  gtggtcccc  1560
ttccggcgc  cgccttggg  gcagccact  ttgatggac  tatctccct  gaggaccaa  1620
ttacaagac  ttaagagca  tctggacaa  cacactgag  tggtcttca  tgcagattt  1680
cctgggctt  acttggaga  ttttgtgag  gaagacctg  gcaacacca  catccagct  1740
ctgcaggga  aagtcactg  ggaattggt  gcagaacag  aaaaccaga  tcttcgaga  1800
ggagagaaa  tgcagttgc  tgctggaga  taccataaa  tctatactg  atcatctag  1860
ccttcctgc  acatgtaca  ctatgtcaa  actacagag  tcgcactgg  gcaagacct  1920
gcatatctg  aagaattaa  ggagaaggt  gagaacgga  gtgaaacag  gcccctgcc  1980
ccagaactt  agcctcttt  ggaagggga  gtaaaaggg  gccctgagc  aacacctct  2040
gtccaaacc  ttctgagac  gcagaggaa  ctccaagaa  ttgaacgaa  gcgaaatag  2100
cctttgcat  agcgcttcc  ccgctttgt  ctgcggaag  tgtatgtct  tcgacgcag  2160
ttcctgatg  ctcgaattt  acttcgaaa  ctgctattt  gccgccctt  cctagagca  2220
ttagcccaa  aggtgacat  tgcaaactt  cgaccattt  aaccagttg  tgagtcaag  2280
gcttcaaac  cagattctt  cgatcctca  ccttcagag  cagattctg  gcatgttca  2340
tctgagctc  gaggagtcc  gatgctgtg  agctacggg  gaaggctgt  acaggctta  2400
tgtctgtgc  aaggacagt  tttgggaga  aaatgattt  gagagaggc  ttcacagta  2460
agcccaggc  ggcctcaag  tcatggtgg  ccctgtttc  gcctgtttt  tcattacat  2520
tatatctcc  gacttagtt  tttttccct  tacatttta  cccctttta  gttctttaa  2580
attatagct  acaggatcc  aggtaaaag  gaagaattt  aatcccaag  tttgaggtg  2640
ttttagttt  tatacagga  ttctctgtg  agacaagac  ggccttgct  acagattta  2700
cagcctctg  ctcctggga  taaaggaat  ggacatcaa  aaaaaaaaa  aaaa  2754



<210> 1003
<211> 758
<212> PRT
<213> Rattus norvegicus
<308> O88496
<400> 1003

Met Ala Val His Arg Gly Ser Ala Arg Ala Ala Pro Ala Ser Asp Lys 
  1               5                  10                  15
Val Gln Lys Asn Lys Pro Ala Gln Thr Ser Gly Leu Glu Gln Gly Ser 
             20                  25                  30
Arg Met Ala Arg Ile Phe Gly Phe Glu Trp Ala Asp Leu Ser Ser Trp 
         35                  40                  45
Gln Ser Val Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Asn Leu 
     50                  55                  60
Ala Val Phe Arg Phe Leu Phe Ala Phe Leu Met Leu Leu Asp Ile Pro 
 65                  70                  75                  80
Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                 85                  90                  95
Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
             100                105                110
Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
         115                120                125
Met Met Leu Gly Leu Trp Tyr Arg Leu Ser Cys Met Leu Phe Leu Leu 
     130                135                140
Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
 145                150                155                160
Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                 165                170                175
Asn His Tyr Trp Ser Val Asp Gly Leu Leu Ser Ala Gln Lys Lys Asn 
             180                185                190
Ala His Val Pro Leu Trp Asn Tyr Thr Val Leu Arg Gly Gln Ile Phe 
         195                200                205
Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
     210                215                220
Glu Gly Tyr Ser Met Glu His Leu Ser Arg His Trp Leu Phe Ser Pro 
 225                230                235                240
Phe Lys Leu Val Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                 245                250                255
Trp Cys Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
             260                265                270
Asp Ala Ser Arg Pro Ile Gly Leu Val Phe Val Ser Tyr Phe His Cys 
         275                280                285
Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Pro Tyr Val Met Leu 
     290                295                300
Ala Ser Ser Pro Leu Phe Cys Ser Ala Glu Trp Pro Arg Lys Leu Val 
 305                310                315                320
Ala Arg Cys Pro Lys Arg Leu Gln Glu Leu Leu Pro Ala Lys Ala Ala 
                 325                330                335
Pro Arg Pro Ser Ala Ser Cys Val Tyr Lys Arg Ala Arg Ala Lys Ala 
             340                345                350
Gly Gln Lys Pro Gly Leu Arg His His Leu Gly Thr Val Phe Thr Leu 
         355                360                365
Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
     370                375                380
Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
 385                390                395                400
Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                 405                410                415
Asp Gly Leu Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
             420                425                430
Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
         435                440                445
Thr Cys Leu Ser Leu Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
     450                455                460
Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
 465                470                475                480
Leu Phe Asp Pro Arg Val Asp Ile Val Gln Ala Val Trp Ser Pro Phe 
                 485                490                495
Arg Arg Thr Pro Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
             500                505                510
Arg Thr Lys Leu Gln Asp Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
         515                520                525
Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
     530                535                540
Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
 545                550                555                560
Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                 565                570                575
Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Val 
             580                585                590
Ser Ser Ser Pro Ser Cys Tyr Met Tyr Ile Tyr Val Asn Thr Thr Glu 
         595                600                605
Val Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
     610                615                620
Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
 625                630                635                640
Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                 645                650                655
Gln Thr Phe Leu Arg Arg Gln Arg Lys Leu Gln Glu Ile Glu Arg Arg 
             660                665                670
Arg Asn Ser Pro Leu His Glu Arg Phe Leu Arg Phe Val Leu Arg Lys 
         675                680                685
Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Arg Ile Ser Leu Arg 
     690                695                700
Asn Leu Leu Phe Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
 705                710                715                720
Thr Tyr Ala Asn Leu Arg Pro Phe Glu Pro Val Asp Glu Ser Ser Ala 
                 725                730                735
Ser Asn Thr Asp Ser Ser Asp Pro His Pro Ser Glu Pro Asp Ser Glu 
             740                745                750
His Val His Ser Glu Leu 
         755



<210> 1005
<211> 758
<212> PRT
<213> Homo sapiens
<308> P38435
<400> 1005

Met Ala Val Ser Ala Gly Ser Ala Arg Thr Ser Pro Ser Ser Asp Lys 
  1               5                  10                  15
Val Gln Lys Asp Lys Ala Glu Leu Ile Ser Gly Pro Arg Gln Asp Ser 
             20                  25                  30
Arg Ile Gly Lys Leu Leu Gly Phe Glu Trp Thr Asp Leu Ser Ser Trp 
         35                  40                  45
Arg Arg Leu Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Ser Leu 
     50                  55                  60
Ala Val Phe Arg Phe Leu Phe Gly Phe Leu Met Val Leu Asp Ile Pro 
 65                  70                  75                  80
Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                 85                  90                  95
Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
             100                105                110
Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
         115                120                125
Met Met Leu Gly Leu Cys Tyr Arg Ile Ser Cys Val Leu Phe Leu Leu 
     130                135                140
Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
 145                150                155                160
Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                 165                170                175
Asn His Tyr Trp Ser Val Asp Gly Leu Leu Asn Ala His Arg Arg Asn 
             180                185                190
Ala His Val Pro Leu Trp Asn Tyr Ala Val Leu Arg Gly Gln Ile Phe 
         195                200                205
Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
     210                215                220
Glu Gly Tyr Ser Met Glu Tyr Leu Ser Arg His Trp Leu Phe Ser Pro 
 225                230                235                240
Phe Lys Leu Leu Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                 245                250                255
Trp Gly Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
             260                265                270
Asp Val Ser Arg Ser Ile Gly Leu Phe Phe Val Ser Tyr Phe His Cys 
         275                280                285
Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Ser Tyr Val Met Leu 
     290                295                300
Ala Ser Ser Pro Leu Phe Cys Ser Pro Glu Trp Pro Arg Lys Leu Val 
 305                310                315                320
Ser Tyr Cys Pro Gln Arg Leu Gln Gln Leu Leu Pro Leu Lys Ala Ala 
                 325                330                335
Pro Gln Pro Ser Val Ser Cys Val Tyr Lys Arg Ser Arg Gly Lys Ser 
             340                345                350
Gly Gln Lys Pro Gly Leu Arg His Gln Leu Gly Ala Ala Phe Thr Leu 
         355                360                365
Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
     370                375                380
Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
 385                390                395                400
Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                 405                410                415
Asp Gly Arg Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
             420                425                430
Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
         435                440                445
Thr Cys Leu Ser Arg Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
     450                455                460
Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
 465                470                475                480
Ile Phe Asp Pro Arg Val Asp Ile Val Gln Ala Ala Trp Ser Pro Phe 
                 485                490                495
Gln Arg Thr Ser Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
             500                505                510
Arg Ala Lys Leu Gln Glu Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
         515                520                525
Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
     530                535                540
Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
 545                550                555                560
Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                 565                570                575
Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Thr 
             580                585                590
Ser Pro Ser Pro Ser Cys Tyr Met Tyr Val Tyr Val Asn Thr Thr Glu 
         595                600                605
Leu Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
     610                615                620
Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
 625                630                635                640
Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                 645                650                655
Gln Thr Phe Leu Arg Arg Gln Gln Arg Leu Gln Glu Ile Glu Arg Arg 
             660                665                670
Arg Asn Thr Pro Phe His Glu Arg Phe Phe Arg Phe Leu Leu Arg Lys 
         675                680                685
Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Cys Ile Ser Leu Arg 
     690                695                700
Asn Leu Ile Leu Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
 705                710                715                720
Thr Tyr Ala Asn Leu Arg Pro Phe Glu Ala Val Gly Glu Leu Asn Pro 
                 725                730                735
Ser Asn Thr Asp Ser Ser His Ser Asn Pro Pro Glu Ser Asn Pro Asp 
             740                745                750
Pro Val His Ser Glu Phe 
         755



<210> 1006
<211> 2754
<212> DNA
<213> Rattus norvegicus
<308> AF065387
<400> 1006

agacagcaa  tctaagtct  gaggttcca  tgattcgga  ctggctgca  agaggttca  60
ctattccct  cagtcatgg  tgtccaccg  ggctctgca  gagctgctc  cgcctcaga  120
aaagtacag  aaaacaagc  tgcacagac  tcggggctg  aacagggca  ccgaatggc  180
agaattttt  ggtttgaat  ggcagattt  tccagctgg  agagtgtcg  gaccctact  240
aaccgacca  cggaccctg  aaacctggc  gtcttccgt  ttctctttg  attcttgat  300
ctgctggac  tcccccagg  acggggcct  agctccctg  accgaaaat  cttggatgg  360
ctggatgtg  gccgcttcc  cttgctgga  gccttgcgc  cactgccac  tgactggat  420
tatctcgtc  acaccatca  gtttctggg  gcactgggc  tgatgctgg  cctgtggta  480
cggctaagc  gtatgttat  cctgctacc  tactggtac  tgtttctcc  ggacaagac  540
tcgtggaac  atcactcct  tctgtatgg  ttgttggcc  ttcagttga  attcatgga  600
gcaaaccac  actggtctg  ggatggcct  ctgagtgcc  aaaagaaga  tgctcacgt  660
cccctttgg  actacacag  cctgcgtgg  cagatcttc  ttgtgtatt  cattgcggg  720
gtgaaaaag  tggatgctg  ctgggttga  ggctactcc  tggagcatt  gtcccggca  780
tggcttttt  gtcccttca  gctagtgtt  tcggaggag  tgacaagcc  gctggtggt  840
cactggtgt  ggcttctcc  tgacctctc  gctggcttc  tgctcttct  cgatgcctc  900
agacccatt  gcctcgtct  cgtgtccta  tttcactgc  tgaactcgc  gctcttcag  960
ataggtatg  tcccctatg  catgctggc  agcagccct  tcttctgct  agctgaatg  1020
cctcggaag  tggtagccc  atgcccgaa  aggctgcaa  agctgctgc  tgccaaagc  1080
gctcctcgg  ctagtgctt  ctgtgtgta  aagagggcc  gggcgaaag  tggtcaaaa  1140
ccaggccta  gccaccatc  gggaactgt  ttcaccctg  tctaccttc  ggagcagct  1200
ttcctgccc  attcccatt  cctcacgca  ggttacaac  actggacga  tgggctgta  1260
ggctattcc  gggacatga  ggtgcactc  cgctcccac  agcatgtaa  gatcaccta  1320
cgtgatggc  tcactggag  gctgggcta  cttaaccct  gggtattca  acagagccg  1380
cgctggaag  accatgcag  catgctgaa  caatatgcc  cttgcctga  cctcctgct  1440
cccaagtac  atgtcactg  gccccagat  tactttgat  tctgggtct  catcaatga  1500
cgcttccag  agaggcttt  tgaccctcg  gtggacatc  tgcaggccg  gtggtcccc  1560
ttccggcgc  cgccttggg  gcagccact  ttgatggac  tatctccct  gaggaccaa  1620
ttacaagac  ttaagagca  tctggacaa  cacactgag  tggtcttca  tgcagattt  1680
cctgggctt  acttggaga  ttttgtgag  gaagacctg  gcaacacca  catccagct  1740
ctgcaggga  aagtcactg  ggaattggt  gcagaacag  aaaaccaga  tcttcgaga  1800
ggagagaaa  tgcagttgc  tgctggaga  taccataaa  tctatactg  atcatctag  1860
ccttcctgc  acatgtaca  ctatgtcaa  actacagag  tcgcactgg  gcaagacct  1920
gcatatctg  aagaattaa  ggagaaggt  gagaacgga  gtgaaacag  gcccctgcc  1980
ccagaactt  agcctcttt  ggaagggga  gtaaaaggg  gccctgagc  aacacctct  2040
gtccaaacc  ttctgagac  gcagaggaa  ctccaagaa  ttgaacgaa  gcgaaatag  2100
cctttgcat  agcgcttcc  ccgctttgt  ctgcggaag  tgtatgtct  tcgacgcag  2160
ttcctgatg  ctcgaattt  acttcgaaa  ctgctattt  gccgccctt  cctagagca  2220
ttagcccaa  aggtgacat  tgcaaactt  cgaccattt  aaccagttg  tgagtcaag  2280
gcttcaaac  cagattctt  cgatcctca  ccttcagag  cagattctg  gcatgttca  2340
tctgagctc  gaggagtcc  gatgctgtg  agctacggg  gaaggctgt  acaggctta  2400
tgtctgtgc  aaggacagt  tttgggaga  aaatgattt  gagagaggc  ttcacagta  2460
agcccaggc  ggcctcaag  tcatggtgg  ccctgtttc  gcctgtttt  tcattacat  2520
tatatctcc  gacttagtt  tttttccct  tacatttta  cccctttta  gttctttaa  2580
attatagct  acaggatcc  aggtaaaag  gaagaattt  aatcccaag  tttgaggtg  2640
ttttagttt  tatacagga  ttctctgtg  agacaagac  ggccttgct  acagattta  2700
cagcctctg  ctcctggga  taaaggaat  ggacatcaa  aaaaaaaaa  aaaa  2754



<210> 1007
<211> 758
<212> PRT
<213> Rattus norvegicus
<308> O88496
<400> 1007

Met Ala Val His Arg Gly Ser Ala Arg Ala Ala Pro Ala Ser Asp Lys 
  1               5                  10                  15
Val Gln Lys Asn Lys Pro Ala Gln Thr Ser Gly Leu Glu Gln Gly Ser 
             20                  25                  30
Arg Met Ala Arg Ile Phe Gly Phe Glu Trp Ala Asp Leu Ser Ser Trp 
         35                  40                  45
Gln Ser Val Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Asn Leu 
     50                  55                  60
Ala Val Phe Arg Phe Leu Phe Ala Phe Leu Met Leu Leu Asp Ile Pro 
 65                  70                  75                  80
Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                 85                  90                  95
Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
             100                105                110
Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
         115                120                125
Met Met Leu Gly Leu Trp Tyr Arg Leu Ser Cys Met Leu Phe Leu Leu 
     130                135                140
Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
 145                150                155                160
Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                 165                170                175
Asn His Tyr Trp Ser Val Asp Gly Leu Leu Ser Ala Gln Lys Lys Asn 
             180                185                190
Ala His Val Pro Leu Trp Asn Tyr Thr Val Leu Arg Gly Gln Ile Phe 
         195                200                205
Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
     210                215                220
Glu Gly Tyr Ser Met Glu His Leu Ser Arg His Trp Leu Phe Ser Pro 
 225                230                235                240
Phe Lys Leu Val Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                 245                250                255
Trp Cys Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
             260                265                270
Asp Ala Ser Arg Pro Ile Gly Leu Val Phe Val Ser Tyr Phe His Cys 
         275                280                285
Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Pro Tyr Val Met Leu 
     290                295                300
Ala Ser Ser Pro Leu Phe Cys Ser Ala Glu Trp Pro Arg Lys Leu Val 
 305                310                315                320
Ala Arg Cys Pro Lys Arg Leu Gln Glu Leu Leu Pro Ala Lys Ala Ala 
                 325                330                335
Pro Arg Pro Ser Ala Ser Cys Val Tyr Lys Arg Ala Arg Ala Lys Ala 
             340                345                350
Gly Gln Lys Pro Gly Leu Arg His His Leu Gly Thr Val Phe Thr Leu 
         355                360                365
Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
     370                375                380
Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
 385                390                395                400
Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                 405                410                415
Asp Gly Leu Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
             420                425                430
Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
         435                440                445
Thr Cys Leu Ser Leu Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
     450                455                460
Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
 465                470                475                480
Leu Phe Asp Pro Arg Val Asp Ile Val Gln Ala Val Trp Ser Pro Phe 
                 485                490                495
Arg Arg Thr Pro Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
             500                505                510
Arg Thr Lys Leu Gln Asp Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
         515                520                525
Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
     530                535                540
Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
 545                550                555                560
Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                 565                570                575
Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Val 
             580                585                590
Ser Ser Ser Pro Ser Cys Tyr Met Tyr Ile Tyr Val Asn Thr Thr Glu 
         595                600                605
Val Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
     610                615                620
Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
 625                630                635                640
Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                 645                650                655
Gln Thr Phe Leu Arg Arg Gln Arg Lys Leu Gln Glu Ile Glu Arg Arg 
             660                665                670
Arg Asn Ser Pro Leu His Glu Arg Phe Leu Arg Phe Val Leu Arg Lys 
         675                680                685
Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Arg Ile Ser Leu Arg 
     690                695                700
Asn Leu Leu Phe Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
 705                710                715                720
Thr Tyr Ala Asn Leu Arg Pro Phe Glu Pro Val Asp Glu Ser Ser Ala 
                 725                730                735
Ser Asn Thr Asp Ser Ser Asp Pro His Pro Ser Glu Pro Asp Ser Glu 
             740                745                750
His Val His Ser Glu Leu 
         755



<210> 1009
<211> 758
<212> PRT
<213> Homo sapiens
<308> P38435
<400> 1009

Met Ala Val Ser Ala Gly Ser Ala Arg Thr Ser Pro Ser Ser Asp Lys 
  1               5                  10                  15
Val Gln Lys Asp Lys Ala Glu Leu Ile Ser Gly Pro Arg Gln Asp Ser 
             20                  25                  30
Arg Ile Gly Lys Leu Leu Gly Phe Glu Trp Thr Asp Leu Ser Ser Trp 
         35                  40                  45
Arg Arg Leu Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Ser Leu 
     50                  55                  60
Ala Val Phe Arg Phe Leu Phe Gly Phe Leu Met Val Leu Asp Ile Pro 
 65                  70                  75                  80
Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                 85                  90                  95
Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
             100                105                110
Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
         115                120                125
Met Met Leu Gly Leu Cys Tyr Arg Ile Ser Cys Val Leu Phe Leu Leu 
     130                135                140
Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
 145                150                155                160
Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                 165                170                175
Asn His Tyr Trp Ser Val Asp Gly Leu Leu Asn Ala His Arg Arg Asn 
             180                185                190
Ala His Val Pro Leu Trp Asn Tyr Ala Val Leu Arg Gly Gln Ile Phe 
         195                200                205
Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
     210                215                220
Glu Gly Tyr Ser Met Glu Tyr Leu Ser Arg His Trp Leu Phe Ser Pro 
 225                230                235                240
Phe Lys Leu Leu Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                 245                250                255
Trp Gly Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
             260                265                270
Asp Val Ser Arg Ser Ile Gly Leu Phe Phe Val Ser Tyr Phe His Cys 
         275                280                285
Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Ser Tyr Val Met Leu 
     290                295                300
Ala Ser Ser Pro Leu Phe Cys Ser Pro Glu Trp Pro Arg Lys Leu Val 
 305                310                315                320
Ser Tyr Cys Pro Gln Arg Leu Gln Gln Leu Leu Pro Leu Lys Ala Ala 
                 325                330                335
Pro Gln Pro Ser Val Ser Cys Val Tyr Lys Arg Ser Arg Gly Lys Ser 
             340                345                350
Gly Gln Lys Pro Gly Leu Arg His Gln Leu Gly Ala Ala Phe Thr Leu 
         355                360                365
Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
     370                375                380
Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
 385                390                395                400
Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                 405                410                415
Asp Gly Arg Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
             420                425                430
Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
         435                440                445
Thr Cys Leu Ser Arg Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
     450                455                460
Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
 465                470                475                480
Ile Phe Asp Pro Arg Val Asp Ile Val Gln Ala Ala Trp Ser Pro Phe 
                 485                490                495
Gln Arg Thr Ser Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
             500                505                510
Arg Ala Lys Leu Gln Glu Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
         515                520                525
Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
     530                535                540
Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
 545                550                555                560
Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                 565                570                575
Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Thr 
             580                585                590
Ser Pro Ser Pro Ser Cys Tyr Met Tyr Val Tyr Val Asn Thr Thr Glu 
         595                600                605
Leu Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
     610                615                620
Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
 625                630                635                640
Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                 645                650                655
Gln Thr Phe Leu Arg Arg Gln Gln Arg Leu Gln Glu Ile Glu Arg Arg 
             660                665                670
Arg Asn Thr Pro Phe His Glu Arg Phe Phe Arg Phe Leu Leu Arg Lys 
         675                680                685
Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Cys Ile Ser Leu Arg 
     690                695                700
Asn Leu Ile Leu Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
 705                710                715                720
Thr Tyr Ala Asn Leu Arg Pro Phe Glu Ala Val Gly Glu Leu Asn Pro 
                 725                730                735
Ser Asn Thr Asp Ser Ser His Ser Asn Pro Pro Glu Ser Asn Pro Asp 
             740                745                750
Pro Val His Ser Glu Phe 
         755



<210> 1010
<211> 2754
<212> DNA
<213> Rattus norvegicus
<308> AF065387
<400> 1010

agacagcaa  tctaagtct  gaggttcca  tgattcgga  ctggctgca  agaggttca  60
ctattccct  cagtcatgg  tgtccaccg  ggctctgca  gagctgctc  cgcctcaga  120
aaagtacag  aaaacaagc  tgcacagac  tcggggctg  aacagggca  ccgaatggc  180
agaattttt  ggtttgaat  ggcagattt  tccagctgg  agagtgtcg  gaccctact  240
aaccgacca  cggaccctg  aaacctggc  gtcttccgt  ttctctttg  attcttgat  300
ctgctggac  tcccccagg  acggggcct  agctccctg  accgaaaat  cttggatgg  360
ctggatgtg  gccgcttcc  cttgctgga  gccttgcgc  cactgccac  tgactggat  420
tatctcgtc  acaccatca  gtttctggg  gcactgggc  tgatgctgg  cctgtggta  480
cggctaagc  gtatgttat  cctgctacc  tactggtac  tgtttctcc  ggacaagac  540
tcgtggaac  atcactcct  tctgtatgg  ttgttggcc  ttcagttga  attcatgga  600
gcaaaccac  actggtctg  ggatggcct  ctgagtgcc  aaaagaaga  tgctcacgt  660
cccctttgg  actacacag  cctgcgtgg  cagatcttc  ttgtgtatt  cattgcggg  720
gtgaaaaag  tggatgctg  ctgggttga  ggctactcc  tggagcatt  gtcccggca  780
tggcttttt  gtcccttca  gctagtgtt  tcggaggag  tgacaagcc  gctggtggt  840
cactggtgt  ggcttctcc  tgacctctc  gctggcttc  tgctcttct  cgatgcctc  900
agacccatt  gcctcgtct  cgtgtccta  tttcactgc  tgaactcgc  gctcttcag  960
ataggtatg  tcccctatg  catgctggc  agcagccct  tcttctgct  agctgaatg  1020
cctcggaag  tggtagccc  atgcccgaa  aggctgcaa  agctgctgc  tgccaaagc  1080
gctcctcgg  ctagtgctt  ctgtgtgta  aagagggcc  gggcgaaag  tggtcaaaa  1140
ccaggccta  gccaccatc  gggaactgt  ttcaccctg  tctaccttc  ggagcagct  1200
ttcctgccc  attcccatt  cctcacgca  ggttacaac  actggacga  tgggctgta  1260
ggctattcc  gggacatga  ggtgcactc  cgctcccac  agcatgtaa  gatcaccta  1320
cgtgatggc  tcactggag  gctgggcta  cttaaccct  gggtattca  acagagccg  1380
cgctggaag  accatgcag  catgctgaa  caatatgcc  cttgcctga  cctcctgct  1440
cccaagtac  atgtcactg  gccccagat  tactttgat  tctgggtct  catcaatga  1500
cgcttccag  agaggcttt  tgaccctcg  gtggacatc  tgcaggccg  gtggtcccc  1560
ttccggcgc  cgccttggg  gcagccact  ttgatggac  tatctccct  gaggaccaa  1620
ttacaagac  ttaagagca  tctggacaa  cacactgag  tggtcttca  tgcagattt  1680
cctgggctt  acttggaga  ttttgtgag  gaagacctg  gcaacacca  catccagct  1740
ctgcaggga  aagtcactg  ggaattggt  gcagaacag  aaaaccaga  tcttcgaga  1800
ggagagaaa  tgcagttgc  tgctggaga  taccataaa  tctatactg  atcatctag  1860
ccttcctgc  acatgtaca  ctatgtcaa  actacagag  tcgcactgg  gcaagacct  1920
gcatatctg  aagaattaa  ggagaaggt  gagaacgga  gtgaaacag  gcccctgcc  1980
ccagaactt  agcctcttt  ggaagggga  gtaaaaggg  gccctgagc  aacacctct  2040
gtccaaacc  ttctgagac  gcagaggaa  ctccaagaa  ttgaacgaa  gcgaaatag  2100
cctttgcat  agcgcttcc  ccgctttgt  ctgcggaag  tgtatgtct  tcgacgcag  2160
ttcctgatg  ctcgaattt  acttcgaaa  ctgctattt  gccgccctt  cctagagca  2220
ttagcccaa  aggtgacat  tgcaaactt  cgaccattt  aaccagttg  tgagtcaag  2280
gcttcaaac  cagattctt  cgatcctca  ccttcagag  cagattctg  gcatgttca  2340
tctgagctc  gaggagtcc  gatgctgtg  agctacggg  gaaggctgt  acaggctta  2400
tgtctgtgc  aaggacagt  tttgggaga  aaatgattt  gagagaggc  ttcacagta  2460
agcccaggc  ggcctcaag  tcatggtgg  ccctgtttc  gcctgtttt  tcattacat  2520
tatatctcc  gacttagtt  tttttccct  tacatttta  cccctttta  gttctttaa  2580
attatagct  acaggatcc  aggtaaaag  gaagaattt  aatcccaag  tttgaggtg  2640
ttttagttt  tatacagga  ttctctgtg  agacaagac  ggccttgct  acagattta  2700
cagcctctg  ctcctggga  taaaggaat  ggacatcaa  aaaaaaaaa  aaaa  2754



<210> 1011
<211> 758
<212> PRT
<213> Rattus norvegicus
<308> O88496
<400> 1011

Met Ala Val His Arg Gly Ser Ala Arg Ala Ala Pro Ala Ser Asp Lys 
  1               5                  10                  15
Val Gln Lys Asn Lys Pro Ala Gln Thr Ser Gly Leu Glu Gln Gly Ser 
             20                  25                  30
Arg Met Ala Arg Ile Phe Gly Phe Glu Trp Ala Asp Leu Ser Ser Trp 
         35                  40                  45
Gln Ser Val Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Asn Leu 
     50                  55                  60
Ala Val Phe Arg Phe Leu Phe Ala Phe Leu Met Leu Leu Asp Ile Pro 
 65                  70                  75                  80
Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                 85                  90                  95
Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
             100                105                110
Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
         115                120                125
Met Met Leu Gly Leu Trp Tyr Arg Leu Ser Cys Met Leu Phe Leu Leu 
     130                135                140
Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
 145                150                155                160
Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                 165                170                175
Asn His Tyr Trp Ser Val Asp Gly Leu Leu Ser Ala Gln Lys Lys Asn 
             180                185                190
Ala His Val Pro Leu Trp Asn Tyr Thr Val Leu Arg Gly Gln Ile Phe 
         195                200                205
Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
     210                215                220
Glu Gly Tyr Ser Met Glu His Leu Ser Arg His Trp Leu Phe Ser Pro 
 225                230                235                240
Phe Lys Leu Val Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                 245                250                255
Trp Cys Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
             260                265                270
Asp Ala Ser Arg Pro Ile Gly Leu Val Phe Val Ser Tyr Phe His Cys 
         275                280                285
Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Pro Tyr Val Met Leu 
     290                295                300
Ala Ser Ser Pro Leu Phe Cys Ser Ala Glu Trp Pro Arg Lys Leu Val 
 305                310                315                320
Ala Arg Cys Pro Lys Arg Leu Gln Glu Leu Leu Pro Ala Lys Ala Ala 
                 325                330                335
Pro Arg Pro Ser Ala Ser Cys Val Tyr Lys Arg Ala Arg Ala Lys Ala 
             340                345                350
Gly Gln Lys Pro Gly Leu Arg His His Leu Gly Thr Val Phe Thr Leu 
         355                360                365
Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
     370                375                380
Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
 385                390                395                400
Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                 405                410                415
Asp Gly Leu Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
             420                425                430
Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
         435                440                445
Thr Cys Leu Ser Leu Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
     450                455                460
Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
 465                470                475                480
Leu Phe Asp Pro Arg Val Asp Ile Val Gln Ala Val Trp Ser Pro Phe 
                 485                490                495
Arg Arg Thr Pro Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
             500                505                510
Arg Thr Lys Leu Gln Asp Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
         515                520                525
Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
     530                535                540
Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
 545                550                555                560
Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                 565                570                575
Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Val 
             580                585                590
Ser Ser Ser Pro Ser Cys Tyr Met Tyr Ile Tyr Val Asn Thr Thr Glu 
         595                600                605
Val Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
     610                615                620
Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
 625                630                635                640
Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                 645                650                655
Gln Thr Phe Leu Arg Arg Gln Arg Lys Leu Gln Glu Ile Glu Arg Arg 
             660                665                670
Arg Asn Ser Pro Leu His Glu Arg Phe Leu Arg Phe Val Leu Arg Lys 
         675                680                685
Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Arg Ile Ser Leu Arg 
     690                695                700
Asn Leu Leu Phe Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
 705                710                715                720
Thr Tyr Ala Asn Leu Arg Pro Phe Glu Pro Val Asp Glu Ser Ser Ala 
                 725                730                735
Ser Asn Thr Asp Ser Ser Asp Pro His Pro Ser Glu Pro Asp Ser Glu 
             740                745                750
His Val His Ser Glu Leu 
         755



<210> 1013
<211> 758
<212> PRT
<213> Homo sapiens
<308> P38435
<400> 1013

Met Ala Val Ser Ala Gly Ser Ala Arg Thr Ser Pro Ser Ser Asp Lys 
  1               5                  10                  15
Val Gln Lys Asp Lys Ala Glu Leu Ile Ser Gly Pro Arg Gln Asp Ser 
             20                  25                  30
Arg Ile Gly Lys Leu Leu Gly Phe Glu Trp Thr Asp Leu Ser Ser Trp 
         35                  40                  45
Arg Arg Leu Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Ser Leu 
     50                  55                  60
Ala Val Phe Arg Phe Leu Phe Gly Phe Leu Met Val Leu Asp Ile Pro 
 65                  70                  75                  80
Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                 85                  90                  95
Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
             100                105                110
Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
         115                120                125
Met Met Leu Gly Leu Cys Tyr Arg Ile Ser Cys Val Leu Phe Leu Leu 
     130                135                140
Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
 145                150                155                160
Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                 165                170                175
Asn His Tyr Trp Ser Val Asp Gly Leu Leu Asn Ala His Arg Arg Asn 
             180                185                190
Ala His Val Pro Leu Trp Asn Tyr Ala Val Leu Arg Gly Gln Ile Phe 
         195                200                205
Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
     210                215                220
Glu Gly Tyr Ser Met Glu Tyr Leu Ser Arg His Trp Leu Phe Ser Pro 
 225                230                235                240
Phe Lys Leu Leu Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                 245                250                255
Trp Gly Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
             260                265                270
Asp Val Ser Arg Ser Ile Gly Leu Phe Phe Val Ser Tyr Phe His Cys 
         275                280                285
Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Ser Tyr Val Met Leu 
     290                295                300
Ala Ser Ser Pro Leu Phe Cys Ser Pro Glu Trp Pro Arg Lys Leu Val 
 305                310                315                320
Ser Tyr Cys Pro Gln Arg Leu Gln Gln Leu Leu Pro Leu Lys Ala Ala 
                 325                330                335
Pro Gln Pro Ser Val Ser Cys Val Tyr Lys Arg Ser Arg Gly Lys Ser 
             340                345                350
Gly Gln Lys Pro Gly Leu Arg His Gln Leu Gly Ala Ala Phe Thr Leu 
         355                360                365
Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
     370                375                380
Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
 385                390                395                400
Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                 405                410                415
Asp Gly Arg Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
             420                425                430
Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
         435                440                445
Thr Cys Leu Ser Arg Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
     450                455                460
Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
 465                470                475                480
Ile Phe Asp Pro Arg Val Asp Ile Val Gln Ala Ala Trp Ser Pro Phe 
                 485                490                495
Gln Arg Thr Ser Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
             500                505                510
Arg Ala Lys Leu Gln Glu Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
         515                520                525
Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
     530                535                540
Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
 545                550                555                560
Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                 565                570                575
Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Thr 
             580                585                590
Ser Pro Ser Pro Ser Cys Tyr Met Tyr Val Tyr Val Asn Thr Thr Glu 
         595                600                605
Leu Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
     610                615                620
Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
 625                630                635                640
Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                 645                650                655
Gln Thr Phe Leu Arg Arg Gln Gln Arg Leu Gln Glu Ile Glu Arg Arg 
             660                665                670
Arg Asn Thr Pro Phe His Glu Arg Phe Phe Arg Phe Leu Leu Arg Lys 
         675                680                685
Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Cys Ile Ser Leu Arg 
     690                695                700
Asn Leu Ile Leu Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
 705                710                715                720
Thr Tyr Ala Asn Leu Arg Pro Phe Glu Ala Val Gly Glu Leu Asn Pro 
                 725                730                735
Ser Asn Thr Asp Ser Ser His Ser Asn Pro Pro Glu Ser Asn Pro Asp 
             740                745                750
Pro Val His Ser Glu Phe 
         755



<210> 1014
<211> 2754
<212> DNA
<213> Rattus norvegicus
<308> AF065387
<400> 1014

agacagcaa  tctaagtct  gaggttcca  tgattcgga  ctggctgca  agaggttca  60
ctattccct  cagtcatgg  tgtccaccg  ggctctgca  gagctgctc  cgcctcaga  120
aaagtacag  aaaacaagc  tgcacagac  tcggggctg  aacagggca  ccgaatggc  180
agaattttt  ggtttgaat  ggcagattt  tccagctgg  agagtgtcg  gaccctact  240
aaccgacca  cggaccctg  aaacctggc  gtcttccgt  ttctctttg  attcttgat  300
ctgctggac  tcccccagg  acggggcct  agctccctg  accgaaaat  cttggatgg  360
ctggatgtg  gccgcttcc  cttgctgga  gccttgcgc  cactgccac  tgactggat  420
tatctcgtc  acaccatca  gtttctggg  gcactgggc  tgatgctgg  cctgtggta  480
cggctaagc  gtatgttat  cctgctacc  tactggtac  tgtttctcc  ggacaagac  540
tcgtggaac  atcactcct  tctgtatgg  ttgttggcc  ttcagttga  attcatgga  600
gcaaaccac  actggtctg  ggatggcct  ctgagtgcc  aaaagaaga  tgctcacgt  660
cccctttgg  actacacag  cctgcgtgg  cagatcttc  ttgtgtatt  cattgcggg  720
gtgaaaaag  tggatgctg  ctgggttga  ggctactcc  tggagcatt  gtcccggca  780
tggcttttt  gtcccttca  gctagtgtt  tcggaggag  tgacaagcc  gctggtggt  840
cactggtgt  ggcttctcc  tgacctctc  gctggcttc  tgctcttct  cgatgcctc  900
agacccatt  gcctcgtct  cgtgtccta  tttcactgc  tgaactcgc  gctcttcag  960
ataggtatg  tcccctatg  catgctggc  agcagccct  tcttctgct  agctgaatg  1020
cctcggaag  tggtagccc  atgcccgaa  aggctgcaa  agctgctgc  tgccaaagc  1080
gctcctcgg  ctagtgctt  ctgtgtgta  aagagggcc  gggcgaaag  tggtcaaaa  1140
ccaggccta  gccaccatc  gggaactgt  ttcaccctg  tctaccttc  ggagcagct  1200
ttcctgccc  attcccatt  cctcacgca  ggttacaac  actggacga  tgggctgta  1260
ggctattcc  gggacatga  ggtgcactc  cgctcccac  agcatgtaa  gatcaccta  1320
cgtgatggc  tcactggag  gctgggcta  cttaaccct  gggtattca  acagagccg  1380
cgctggaag  accatgcag  catgctgaa  caatatgcc  cttgcctga  cctcctgct  1440
cccaagtac  atgtcactg  gccccagat  tactttgat  tctgggtct  catcaatga  1500
cgcttccag  agaggcttt  tgaccctcg  gtggacatc  tgcaggccg  gtggtcccc  1560
ttccggcgc  cgccttggg  gcagccact  ttgatggac  tatctccct  gaggaccaa  1620
ttacaagac  ttaagagca  tctggacaa  cacactgag  tggtcttca  tgcagattt  1680
cctgggctt  acttggaga  ttttgtgag  gaagacctg  gcaacacca  catccagct  1740
ctgcaggga  aagtcactg  ggaattggt  gcagaacag  aaaaccaga  tcttcgaga  1800
ggagagaaa  tgcagttgc  tgctggaga  taccataaa  tctatactg  atcatctag  1860
ccttcctgc  acatgtaca  ctatgtcaa  actacagag  tcgcactgg  gcaagacct  1920
gcatatctg  aagaattaa  ggagaaggt  gagaacgga  gtgaaacag  gcccctgcc  1980
ccagaactt  agcctcttt  ggaagggga  gtaaaaggg  gccctgagc  aacacctct  2040
gtccaaacc  ttctgagac  gcagaggaa  ctccaagaa  ttgaacgaa  gcgaaatag  2100
cctttgcat  agcgcttcc  ccgctttgt  ctgcggaag  tgtatgtct  tcgacgcag  2160
ttcctgatg  ctcgaattt  acttcgaaa  ctgctattt  gccgccctt  cctagagca  2220
ttagcccaa  aggtgacat  tgcaaactt  cgaccattt  aaccagttg  tgagtcaag  2280
gcttcaaac  cagattctt  cgatcctca  ccttcagag  cagattctg  gcatgttca  2340
tctgagctc  gaggagtcc  gatgctgtg  agctacggg  gaaggctgt  acaggctta  2400
tgtctgtgc  aaggacagt  tttgggaga  aaatgattt  gagagaggc  ttcacagta  2460
agcccaggc  ggcctcaag  tcatggtgg  ccctgtttc  gcctgtttt  tcattacat  2520
tatatctcc  gacttagtt  tttttccct  tacatttta  cccctttta  gttctttaa  2580
attatagct  acaggatcc  aggtaaaag  gaagaattt  aatcccaag  tttgaggtg  2640
ttttagttt  tatacagga  ttctctgtg  agacaagac  ggccttgct  acagattta  2700
cagcctctg  ctcctggga  taaaggaat  ggacatcaa  aaaaaaaaa  aaaa  2754



<210> 1015
<211> 758
<212> PRT
<213> Rattus norvegicus
<308> O88496
<400> 1015

Met Ala Val His Arg Gly Ser Ala Arg Ala Ala Pro Ala Ser Asp Lys 
  1               5                  10                  15
Val Gln Lys Asn Lys Pro Ala Gln Thr Ser Gly Leu Glu Gln Gly Ser 
             20                  25                  30
Arg Met Ala Arg Ile Phe Gly Phe Glu Trp Ala Asp Leu Ser Ser Trp 
         35                  40                  45
Gln Ser Val Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Asn Leu 
     50                  55                  60
Ala Val Phe Arg Phe Leu Phe Ala Phe Leu Met Leu Leu Asp Ile Pro 
 65                  70                  75                  80
Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                 85                  90                  95
Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
             100                105                110
Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
         115                120                125
Met Met Leu Gly Leu Trp Tyr Arg Leu Ser Cys Met Leu Phe Leu Leu 
     130                135                140
Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
 145                150                155                160
Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                 165                170                175
Asn His Tyr Trp Ser Val Asp Gly Leu Leu Ser Ala Gln Lys Lys Asn 
             180                185                190
Ala His Val Pro Leu Trp Asn Tyr Thr Val Leu Arg Gly Gln Ile Phe 
         195                200                205
Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
     210                215                220
Glu Gly Tyr Ser Met Glu His Leu Ser Arg His Trp Leu Phe Ser Pro 
 225                230                235                240
Phe Lys Leu Val Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                 245                250                255
Trp Cys Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
             260                265                270
Asp Ala Ser Arg Pro Ile Gly Leu Val Phe Val Ser Tyr Phe His Cys 
         275                280                285
Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Pro Tyr Val Met Leu 
     290                295                300
Ala Ser Ser Pro Leu Phe Cys Ser Ala Glu Trp Pro Arg Lys Leu Val 
 305                310                315                320
Ala Arg Cys Pro Lys Arg Leu Gln Glu Leu Leu Pro Ala Lys Ala Ala 
                 325                330                335
Pro Arg Pro Ser Ala Ser Cys Val Tyr Lys Arg Ala Arg Ala Lys Ala 
             340                345                350
Gly Gln Lys Pro Gly Leu Arg His His Leu Gly Thr Val Phe Thr Leu 
         355                360                365
Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
     370                375                380
Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
 385                390                395                400
Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                 405                410                415
Asp Gly Leu Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
             420                425                430
Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
         435                440                445
Thr Cys Leu Ser Leu Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
     450                455                460
Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
 465                470                475                480
Leu Phe Asp Pro Arg Val Asp Ile Val Gln Ala Val Trp Ser Pro Phe 
                 485                490                495
Arg Arg Thr Pro Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
             500                505                510
Arg Thr Lys Leu Gln Asp Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
         515                520                525
Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
     530                535                540
Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
 545                550                555                560
Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                 565                570                575
Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Val 
             580                585                590
Ser Ser Ser Pro Ser Cys Tyr Met Tyr Ile Tyr Val Asn Thr Thr Glu 
         595                600                605
Val Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
     610                615                620
Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
 625                630                635                640
Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                 645                650                655
Gln Thr Phe Leu Arg Arg Gln Arg Lys Leu Gln Glu Ile Glu Arg Arg 
             660                665                670
Arg Asn Ser Pro Leu His Glu Arg Phe Leu Arg Phe Val Leu Arg Lys 
         675                680                685
Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Arg Ile Ser Leu Arg 
     690                695                700
Asn Leu Leu Phe Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
 705                710                715                720
Thr Tyr Ala Asn Leu Arg Pro Phe Glu Pro Val Asp Glu Ser Ser Ala 
                 725                730                735
Ser Asn Thr Asp Ser Ser Asp Pro His Pro Ser Glu Pro Asp Ser Glu 
             740                745                750
His Val His Ser Glu Leu 
         755



<210> 1017
<211> 758
<212> PRT
<213> Homo sapiens
<308> P38435
<400> 1017

Met Ala Val Ser Ala Gly Ser Ala Arg Thr Ser Pro Ser Ser Asp Lys 
  1               5                  10                  15
Val Gln Lys Asp Lys Ala Glu Leu Ile Ser Gly Pro Arg Gln Asp Ser 
             20                  25                  30
Arg Ile Gly Lys Leu Leu Gly Phe Glu Trp Thr Asp Leu Ser Ser Trp 
         35                  40                  45
Arg Arg Leu Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Ser Leu 
     50                  55                  60
Ala Val Phe Arg Phe Leu Phe Gly Phe Leu Met Val Leu Asp Ile Pro 
 65                  70                  75                  80
Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                 85                  90                  95
Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
             100                105                110
Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
         115                120                125
Met Met Leu Gly Leu Cys Tyr Arg Ile Ser Cys Val Leu Phe Leu Leu 
     130                135                140
Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
 145                150                155                160
Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                 165                170                175
Asn His Tyr Trp Ser Val Asp Gly Leu Leu Asn Ala His Arg Arg Asn 
             180                185                190
Ala His Val Pro Leu Trp Asn Tyr Ala Val Leu Arg Gly Gln Ile Phe 
         195                200                205
Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
     210                215                220
Glu Gly Tyr Ser Met Glu Tyr Leu Ser Arg His Trp Leu Phe Ser Pro 
 225                230                235                240
Phe Lys Leu Leu Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                 245                250                255
Trp Gly Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
             260                265                270
Asp Val Ser Arg Ser Ile Gly Leu Phe Phe Val Ser Tyr Phe His Cys 
         275                280                285
Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Ser Tyr Val Met Leu 
     290                295                300
Ala Ser Ser Pro Leu Phe Cys Ser Pro Glu Trp Pro Arg Lys Leu Val 
 305                310                315                320
Ser Tyr Cys Pro Gln Arg Leu Gln Gln Leu Leu Pro Leu Lys Ala Ala 
                 325                330                335
Pro Gln Pro Ser Val Ser Cys Val Tyr Lys Arg Ser Arg Gly Lys Ser 
             340                345                350
Gly Gln Lys Pro Gly Leu Arg His Gln Leu Gly Ala Ala Phe Thr Leu 
         355                360                365
Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
     370                375                380
Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
 385                390                395                400
Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                 405                410                415
Asp Gly Arg Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
             420                425                430
Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
         435                440                445
Thr Cys Leu Ser Arg Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
     450                455                460
Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
 465                470                475                480
Ile Phe Asp Pro Arg Val Asp Ile Val Gln Ala Ala Trp Ser Pro Phe 
                 485                490                495
Gln Arg Thr Ser Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
             500                505                510
Arg Ala Lys Leu Gln Glu Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
         515                520                525
Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
     530                535                540
Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
 545                550                555                560
Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                 565                570                575
Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Thr 
             580                585                590
Ser Pro Ser Pro Ser Cys Tyr Met Tyr Val Tyr Val Asn Thr Thr Glu 
         595                600                605
Leu Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
     610                615                620
Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
 625                630                635                640
Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                 645                650                655
Gln Thr Phe Leu Arg Arg Gln Gln Arg Leu Gln Glu Ile Glu Arg Arg 
             660                665                670
Arg Asn Thr Pro Phe His Glu Arg Phe Phe Arg Phe Leu Leu Arg Lys 
         675                680                685
Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Cys Ile Ser Leu Arg 
     690                695                700
Asn Leu Ile Leu Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
 705                710                715                720
Thr Tyr Ala Asn Leu Arg Pro Phe Glu Ala Val Gly Glu Leu Asn Pro 
                 725                730                735
Ser Asn Thr Asp Ser Ser His Ser Asn Pro Pro Glu Ser Asn Pro Asp 
             740                745                750
Pro Val His Ser Glu Phe 
         755



<210> 1018
<211> 2754
<212> DNA
<213> Rattus norvegicus
<308> AF065387
<400> 1018

agacagcaa  tctaagtct  gaggttcca  tgattcgga  ctggctgca  agaggttca  60
ctattccct  cagtcatgg  tgtccaccg  ggctctgca  gagctgctc  cgcctcaga  120
aaagtacag  aaaacaagc  tgcacagac  tcggggctg  aacagggca  ccgaatggc  180
agaattttt  ggtttgaat  ggcagattt  tccagctgg  agagtgtcg  gaccctact  240
aaccgacca  cggaccctg  aaacctggc  gtcttccgt  ttctctttg  attcttgat  300
ctgctggac  tcccccagg  acggggcct  agctccctg  accgaaaat  cttggatgg  360
ctggatgtg  gccgcttcc  cttgctgga  gccttgcgc  cactgccac  tgactggat  420
tatctcgtc  acaccatca  gtttctggg  gcactgggc  tgatgctgg  cctgtggta  480
cggctaagc  gtatgttat  cctgctacc  tactggtac  tgtttctcc  ggacaagac  540
tcgtggaac  atcactcct  tctgtatgg  ttgttggcc  ttcagttga  attcatgga  600
gcaaaccac  actggtctg  ggatggcct  ctgagtgcc  aaaagaaga  tgctcacgt  660
cccctttgg  actacacag  cctgcgtgg  cagatcttc  ttgtgtatt  cattgcggg  720
gtgaaaaag  tggatgctg  ctgggttga  ggctactcc  tggagcatt  gtcccggca  780
tggcttttt  gtcccttca  gctagtgtt  tcggaggag  tgacaagcc  gctggtggt  840
cactggtgt  ggcttctcc  tgacctctc  gctggcttc  tgctcttct  cgatgcctc  900
agacccatt  gcctcgtct  cgtgtccta  tttcactgc  tgaactcgc  gctcttcag  960
ataggtatg  tcccctatg  catgctggc  agcagccct  tcttctgct  agctgaatg  1020
cctcggaag  tggtagccc  atgcccgaa  aggctgcaa  agctgctgc  tgccaaagc  1080
gctcctcgg  ctagtgctt  ctgtgtgta  aagagggcc  gggcgaaag  tggtcaaaa  1140
ccaggccta  gccaccatc  gggaactgt  ttcaccctg  tctaccttc  ggagcagct  1200
ttcctgccc  attcccatt  cctcacgca  ggttacaac  actggacga  tgggctgta  1260
ggctattcc  gggacatga  ggtgcactc  cgctcccac  agcatgtaa  gatcaccta  1320
cgtgatggc  tcactggag  gctgggcta  cttaaccct  gggtattca  acagagccg  1380
cgctggaag  accatgcag  catgctgaa  caatatgcc  cttgcctga  cctcctgct  1440
cccaagtac  atgtcactg  gccccagat  tactttgat  tctgggtct  catcaatga  1500
cgcttccag  agaggcttt  tgaccctcg  gtggacatc  tgcaggccg  gtggtcccc  1560
ttccggcgc  cgccttggg  gcagccact  ttgatggac  tatctccct  gaggaccaa  1620
ttacaagac  ttaagagca  tctggacaa  cacactgag  tggtcttca  tgcagattt  1680
cctgggctt  acttggaga  ttttgtgag  gaagacctg  gcaacacca  catccagct  1740
ctgcaggga  aagtcactg  ggaattggt  gcagaacag  aaaaccaga  tcttcgaga  1800
ggagagaaa  tgcagttgc  tgctggaga  taccataaa  tctatactg  atcatctag  1860
ccttcctgc  acatgtaca  ctatgtcaa  actacagag  tcgcactgg  gcaagacct  1920
gcatatctg  aagaattaa  ggagaaggt  gagaacgga  gtgaaacag  gcccctgcc  1980
ccagaactt  agcctcttt  ggaagggga  gtaaaaggg  gccctgagc  aacacctct  2040
gtccaaacc  ttctgagac  gcagaggaa  ctccaagaa  ttgaacgaa  gcgaaatag  2100
cctttgcat  agcgcttcc  ccgctttgt  ctgcggaag  tgtatgtct  tcgacgcag  2160
ttcctgatg  ctcgaattt  acttcgaaa  ctgctattt  gccgccctt  cctagagca  2220
ttagcccaa  aggtgacat  tgcaaactt  cgaccattt  aaccagttg  tgagtcaag  2280
gcttcaaac  cagattctt  cgatcctca  ccttcagag  cagattctg  gcatgttca  2340
tctgagctc  gaggagtcc  gatgctgtg  agctacggg  gaaggctgt  acaggctta  2400
tgtctgtgc  aaggacagt  tttgggaga  aaatgattt  gagagaggc  ttcacagta  2460
agcccaggc  ggcctcaag  tcatggtgg  ccctgtttc  gcctgtttt  tcattacat  2520
tatatctcc  gacttagtt  tttttccct  tacatttta  cccctttta  gttctttaa  2580
attatagct  acaggatcc  aggtaaaag  gaagaattt  aatcccaag  tttgaggtg  2640
ttttagttt  tatacagga  ttctctgtg  agacaagac  ggccttgct  acagattta  2700
cagcctctg  ctcctggga  taaaggaat  ggacatcaa  aaaaaaaaa  aaaa  2754



<210> 1019
<211> 758
<212> PRT
<213> Rattus norvegicus
<308> O88496
<400> 1019

Met Ala Val His Arg Gly Ser Ala Arg Ala Ala Pro Ala Ser Asp Lys 
  1               5                  10                  15
Val Gln Lys Asn Lys Pro Ala Gln Thr Ser Gly Leu Glu Gln Gly Ser 
             20                  25                  30
Arg Met Ala Arg Ile Phe Gly Phe Glu Trp Ala Asp Leu Ser Ser Trp 
         35                  40                  45
Gln Ser Val Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Asn Leu 
     50                  55                  60
Ala Val Phe Arg Phe Leu Phe Ala Phe Leu Met Leu Leu Asp Ile Pro 
 65                  70                  75                  80
Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                 85                  90                  95
Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
             100                105                110
Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
         115                120                125
Met Met Leu Gly Leu Trp Tyr Arg Leu Ser Cys Met Leu Phe Leu Leu 
     130                135                140
Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
 145                150                155                160
Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                 165                170                175
Asn His Tyr Trp Ser Val Asp Gly Leu Leu Ser Ala Gln Lys Lys Asn 
             180                185                190
Ala His Val Pro Leu Trp Asn Tyr Thr Val Leu Arg Gly Gln Ile Phe 
         195                200                205
Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
     210                215                220
Glu Gly Tyr Ser Met Glu His Leu Ser Arg His Trp Leu Phe Ser Pro 
 225                230                235                240
Phe Lys Leu Val Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                 245                250                255
Trp Cys Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
             260                265                270
Asp Ala Ser Arg Pro Ile Gly Leu Val Phe Val Ser Tyr Phe His Cys 
         275                280                285
Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Pro Tyr Val Met Leu 
     290                295                300
Ala Ser Ser Pro Leu Phe Cys Ser Ala Glu Trp Pro Arg Lys Leu Val 
 305                310                315                320
Ala Arg Cys Pro Lys Arg Leu Gln Glu Leu Leu Pro Ala Lys Ala Ala 
                 325                330                335
Pro Arg Pro Ser Ala Ser Cys Val Tyr Lys Arg Ala Arg Ala Lys Ala 
             340                345                350
Gly Gln Lys Pro Gly Leu Arg His His Leu Gly Thr Val Phe Thr Leu 
         355                360                365
Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
     370                375                380
Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
 385                390                395                400
Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                 405                410                415
Asp Gly Leu Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
             420                425                430
Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
         435                440                445
Thr Cys Leu Ser Leu Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
     450                455                460
Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
 465                470                475                480
Leu Phe Asp Pro Arg Val Asp Ile Val Gln Ala Val Trp Ser Pro Phe 
                 485                490                495
Arg Arg Thr Pro Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
             500                505                510
Arg Thr Lys Leu Gln Asp Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
         515                520                525
Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
     530                535                540
Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
 545                550                555                560
Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                 565                570                575
Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Val 
             580                585                590
Ser Ser Ser Pro Ser Cys Tyr Met Tyr Ile Tyr Val Asn Thr Thr Glu 
         595                600                605
Val Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
     610                615                620
Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
 625                630                635                640
Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                 645                650                655
Gln Thr Phe Leu Arg Arg Gln Arg Lys Leu Gln Glu Ile Glu Arg Arg 
             660                665                670
Arg Asn Ser Pro Leu His Glu Arg Phe Leu Arg Phe Val Leu Arg Lys 
         675                680                685
Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Arg Ile Ser Leu Arg 
     690                695                700
Asn Leu Leu Phe Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
 705                710                715                720
Thr Tyr Ala Asn Leu Arg Pro Phe Glu Pro Val Asp Glu Ser Ser Ala 
                 725                730                735
Ser Asn Thr Asp Ser Ser Asp Pro His Pro Ser Glu Pro Asp Ser Glu 
             740                745                750
His Val His Ser Glu Leu 
         755



<210> 1021
<211> 758
<212> PRT
<213> Homo sapiens
<308> P38435
<400> 1021

Met Ala Val Ser Ala Gly Ser Ala Arg Thr Ser Pro Ser Ser Asp Lys 
  1               5                  10                  15
Val Gln Lys Asp Lys Ala Glu Leu Ile Ser Gly Pro Arg Gln Asp Ser 
             20                  25                  30
Arg Ile Gly Lys Leu Leu Gly Phe Glu Trp Thr Asp Leu Ser Ser Trp 
         35                  40                  45
Arg Arg Leu Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Ser Leu 
     50                  55                  60
Ala Val Phe Arg Phe Leu Phe Gly Phe Leu Met Val Leu Asp Ile Pro 
 65                  70                  75                  80
Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                 85                  90                  95
Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
             100                105                110
Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
         115                120                125
Met Met Leu Gly Leu Cys Tyr Arg Ile Ser Cys Val Leu Phe Leu Leu 
     130                135                140
Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
 145                150                155                160
Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                 165                170                175
Asn His Tyr Trp Ser Val Asp Gly Leu Leu Asn Ala His Arg Arg Asn 
             180                185                190
Ala His Val Pro Leu Trp Asn Tyr Ala Val Leu Arg Gly Gln Ile Phe 
         195                200                205
Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
     210                215                220
Glu Gly Tyr Ser Met Glu Tyr Leu Ser Arg His Trp Leu Phe Ser Pro 
 225                230                235                240
Phe Lys Leu Leu Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                 245                250                255
Trp Gly Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
             260                265                270
Asp Val Ser Arg Ser Ile Gly Leu Phe Phe Val Ser Tyr Phe His Cys 
         275                280                285
Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Ser Tyr Val Met Leu 
     290                295                300
Ala Ser Ser Pro Leu Phe Cys Ser Pro Glu Trp Pro Arg Lys Leu Val 
 305                310                315                320
Ser Tyr Cys Pro Gln Arg Leu Gln Gln Leu Leu Pro Leu Lys Ala Ala 
                 325                330                335
Pro Gln Pro Ser Val Ser Cys Val Tyr Lys Arg Ser Arg Gly Lys Ser 
             340                345                350
Gly Gln Lys Pro Gly Leu Arg His Gln Leu Gly Ala Ala Phe Thr Leu 
         355                360                365
Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
     370                375                380
Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
 385                390                395                400
Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                 405                410                415
Asp Gly Arg Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
             420                425                430
Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
         435                440                445
Thr Cys Leu Ser Arg Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
     450                455                460
Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
 465                470                475                480
Ile Phe Asp Pro Arg Val Asp Ile Val Gln Ala Ala Trp Ser Pro Phe 
                 485                490                495
Gln Arg Thr Ser Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
             500                505                510
Arg Ala Lys Leu Gln Glu Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
         515                520                525
Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
     530                535                540
Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
 545                550                555                560
Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                 565                570                575
Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Thr 
             580                585                590
Ser Pro Ser Pro Ser Cys Tyr Met Tyr Val Tyr Val Asn Thr Thr Glu 
         595                600                605
Leu Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
     610                615                620
Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
 625                630                635                640
Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                 645                650                655
Gln Thr Phe Leu Arg Arg Gln Gln Arg Leu Gln Glu Ile Glu Arg Arg 
             660                665                670
Arg Asn Thr Pro Phe His Glu Arg Phe Phe Arg Phe Leu Leu Arg Lys 
         675                680                685
Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Cys Ile Ser Leu Arg 
     690                695                700
Asn Leu Ile Leu Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
 705                710                715                720
Thr Tyr Ala Asn Leu Arg Pro Phe Glu Ala Val Gly Glu Leu Asn Pro 
                 725                730                735
Ser Asn Thr Asp Ser Ser His Ser Asn Pro Pro Glu Ser Asn Pro Asp 
             740                745                750
Pro Val His Ser Glu Phe 
         755



<210> 1022
<211> 2754
<212> DNA
<213> Rattus norvegicus
<308> AF065387
<400> 1022

agacagcaa  tctaagtct  gaggttcca  tgattcgga  ctggctgca  agaggttca  60
ctattccct  cagtcatgg  tgtccaccg  ggctctgca  gagctgctc  cgcctcaga  120
aaagtacag  aaaacaagc  tgcacagac  tcggggctg  aacagggca  ccgaatggc  180
agaattttt  ggtttgaat  ggcagattt  tccagctgg  agagtgtcg  gaccctact  240
aaccgacca  cggaccctg  aaacctggc  gtcttccgt  ttctctttg  attcttgat  300
ctgctggac  tcccccagg  acggggcct  agctccctg  accgaaaat  cttggatgg  360
ctggatgtg  gccgcttcc  cttgctgga  gccttgcgc  cactgccac  tgactggat  420
tatctcgtc  acaccatca  gtttctggg  gcactgggc  tgatgctgg  cctgtggta  480
cggctaagc  gtatgttat  cctgctacc  tactggtac  tgtttctcc  ggacaagac  540
tcgtggaac  atcactcct  tctgtatgg  ttgttggcc  ttcagttga  attcatgga  600
gcaaaccac  actggtctg  ggatggcct  ctgagtgcc  aaaagaaga  tgctcacgt  660
cccctttgg  actacacag  cctgcgtgg  cagatcttc  ttgtgtatt  cattgcggg  720
gtgaaaaag  tggatgctg  ctgggttga  ggctactcc  tggagcatt  gtcccggca  780
tggcttttt  gtcccttca  gctagtgtt  tcggaggag  tgacaagcc  gctggtggt  840
cactggtgt  ggcttctcc  tgacctctc  gctggcttc  tgctcttct  cgatgcctc  900
agacccatt  gcctcgtct  cgtgtccta  tttcactgc  tgaactcgc  gctcttcag  960
ataggtatg  tcccctatg  catgctggc  agcagccct  tcttctgct  agctgaatg  1020
cctcggaag  tggtagccc  atgcccgaa  aggctgcaa  agctgctgc  tgccaaagc  1080
gctcctcgg  ctagtgctt  ctgtgtgta  aagagggcc  gggcgaaag  tggtcaaaa  1140
ccaggccta  gccaccatc  gggaactgt  ttcaccctg  tctaccttc  ggagcagct  1200
ttcctgccc  attcccatt  cctcacgca  ggttacaac  actggacga  tgggctgta  1260
ggctattcc  gggacatga  ggtgcactc  cgctcccac  agcatgtaa  gatcaccta  1320
cgtgatggc  tcactggag  gctgggcta  cttaaccct  gggtattca  acagagccg  1380
cgctggaag  accatgcag  catgctgaa  caatatgcc  cttgcctga  cctcctgct  1440
cccaagtac  atgtcactg  gccccagat  tactttgat  tctgggtct  catcaatga  1500
cgcttccag  agaggcttt  tgaccctcg  gtggacatc  tgcaggccg  gtggtcccc  1560
ttccggcgc  cgccttggg  gcagccact  ttgatggac  tatctccct  gaggaccaa  1620
ttacaagac  ttaagagca  tctggacaa  cacactgag  tggtcttca  tgcagattt  1680
cctgggctt  acttggaga  ttttgtgag  gaagacctg  gcaacacca  catccagct  1740
ctgcaggga  aagtcactg  ggaattggt  gcagaacag  aaaaccaga  tcttcgaga  1800
ggagagaaa  tgcagttgc  tgctggaga  taccataaa  tctatactg  atcatctag  1860
ccttcctgc  acatgtaca  ctatgtcaa  actacagag  tcgcactgg  gcaagacct  1920
gcatatctg  aagaattaa  ggagaaggt  gagaacgga  gtgaaacag  gcccctgcc  1980
ccagaactt  agcctcttt  ggaagggga  gtaaaaggg  gccctgagc  aacacctct  2040
gtccaaacc  ttctgagac  gcagaggaa  ctccaagaa  ttgaacgaa  gcgaaatag  2100
cctttgcat  agcgcttcc  ccgctttgt  ctgcggaag  tgtatgtct  tcgacgcag  2160
ttcctgatg  ctcgaattt  acttcgaaa  ctgctattt  gccgccctt  cctagagca  2220
ttagcccaa  aggtgacat  tgcaaactt  cgaccattt  aaccagttg  tgagtcaag  2280
gcttcaaac  cagattctt  cgatcctca  ccttcagag  cagattctg  gcatgttca  2340
tctgagctc  gaggagtcc  gatgctgtg  agctacggg  gaaggctgt  acaggctta  2400
tgtctgtgc  aaggacagt  tttgggaga  aaatgattt  gagagaggc  ttcacagta  2460
agcccaggc  ggcctcaag  tcatggtgg  ccctgtttc  gcctgtttt  tcattacat  2520
tatatctcc  gacttagtt  tttttccct  tacatttta  cccctttta  gttctttaa  2580
attatagct  acaggatcc  aggtaaaag  gaagaattt  aatcccaag  tttgaggtg  2640
ttttagttt  tatacagga  ttctctgtg  agacaagac  ggccttgct  acagattta  2700
cagcctctg  ctcctggga  taaaggaat  ggacatcaa  aaaaaaaaa  aaaa  2754



<210> 1023
<211> 758
<212> PRT
<213> Rattus norvegicus
<308> O88496
<400> 1023

Met Ala Val His Arg Gly Ser Ala Arg Ala Ala Pro Ala Ser Asp Lys 
  1               5                  10                  15
Val Gln Lys Asn Lys Pro Ala Gln Thr Ser Gly Leu Glu Gln Gly Ser 
             20                  25                  30
Arg Met Ala Arg Ile Phe Gly Phe Glu Trp Ala Asp Leu Ser Ser Trp 
         35                  40                  45
Gln Ser Val Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Asn Leu 
     50                  55                  60
Ala Val Phe Arg Phe Leu Phe Ala Phe Leu Met Leu Leu Asp Ile Pro 
 65                  70                  75                  80
Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                 85                  90                  95
Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
             100                105                110
Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
         115                120                125
Met Met Leu Gly Leu Trp Tyr Arg Leu Ser Cys Met Leu Phe Leu Leu 
     130                135                140
Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
 145                150                155                160
Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                 165                170                175
Asn His Tyr Trp Ser Val Asp Gly Leu Leu Ser Ala Gln Lys Lys Asn 
             180                185                190
Ala His Val Pro Leu Trp Asn Tyr Thr Val Leu Arg Gly Gln Ile Phe 
         195                200                205
Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
     210                215                220
Glu Gly Tyr Ser Met Glu His Leu Ser Arg His Trp Leu Phe Ser Pro 
 225                230                235                240
Phe Lys Leu Val Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                 245                250                255
Trp Cys Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
             260                265                270
Asp Ala Ser Arg Pro Ile Gly Leu Val Phe Val Ser Tyr Phe His Cys 
         275                280                285
Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Pro Tyr Val Met Leu 
     290                295                300
Ala Ser Ser Pro Leu Phe Cys Ser Ala Glu Trp Pro Arg Lys Leu Val 
 305                310                315                320
Ala Arg Cys Pro Lys Arg Leu Gln Glu Leu Leu Pro Ala Lys Ala Ala 
                 325                330                335
Pro Arg Pro Ser Ala Ser Cys Val Tyr Lys Arg Ala Arg Ala Lys Ala 
             340                345                350
Gly Gln Lys Pro Gly Leu Arg His His Leu Gly Thr Val Phe Thr Leu 
         355                360                365
Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
     370                375                380
Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
 385                390                395                400
Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                 405                410                415
Asp Gly Leu Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
             420                425                430
Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
         435                440                445
Thr Cys Leu Ser Leu Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
     450                455                460
Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
 465                470                475                480
Leu Phe Asp Pro Arg Val Asp Ile Val Gln Ala Val Trp Ser Pro Phe 
                 485                490                495
Arg Arg Thr Pro Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
             500                505                510
Arg Thr Lys Leu Gln Asp Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
         515                520                525
Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
     530                535                540
Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
 545                550                555                560
Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                 565                570                575
Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Val 
             580                585                590
Ser Ser Ser Pro Ser Cys Tyr Met Tyr Ile Tyr Val Asn Thr Thr Glu 
         595                600                605
Val Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
     610                615                620
Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
 625                630                635                640
Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                 645                650                655
Gln Thr Phe Leu Arg Arg Gln Arg Lys Leu Gln Glu Ile Glu Arg Arg 
             660                665                670
Arg Asn Ser Pro Leu His Glu Arg Phe Leu Arg Phe Val Leu Arg Lys 
         675                680                685
Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Arg Ile Ser Leu Arg 
     690                695                700
Asn Leu Leu Phe Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
 705                710                715                720
Thr Tyr Ala Asn Leu Arg Pro Phe Glu Pro Val Asp Glu Ser Ser Ala 
                 725                730                735
Ser Asn Thr Asp Ser Ser Asp Pro His Pro Ser Glu Pro Asp Ser Glu 
             740                745                750
His Val His Ser Glu Leu 
         755



<210> 1025
<211> 758
<212> PRT
<213> Homo sapiens
<308> P38435
<400> 1025

Met Ala Val Ser Ala Gly Ser Ala Arg Thr Ser Pro Ser Ser Asp Lys 
  1               5                  10                  15
Val Gln Lys Asp Lys Ala Glu Leu Ile Ser Gly Pro Arg Gln Asp Ser 
             20                  25                  30
Arg Ile Gly Lys Leu Leu Gly Phe Glu Trp Thr Asp Leu Ser Ser Trp 
         35                  40                  45
Arg Arg Leu Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Ser Leu 
     50                  55                  60
Ala Val Phe Arg Phe Leu Phe Gly Phe Leu Met Val Leu Asp Ile Pro 
 65                  70                  75                  80
Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                 85                  90                  95
Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
             100                105                110
Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
         115                120                125
Met Met Leu Gly Leu Cys Tyr Arg Ile Ser Cys Val Leu Phe Leu Leu 
     130                135                140
Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
 145                150                155                160
Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                 165                170                175
Asn His Tyr Trp Ser Val Asp Gly Leu Leu Asn Ala His Arg Arg Asn 
             180                185                190
Ala His Val Pro Leu Trp Asn Tyr Ala Val Leu Arg Gly Gln Ile Phe 
         195                200                205
Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
     210                215                220
Glu Gly Tyr Ser Met Glu Tyr Leu Ser Arg His Trp Leu Phe Ser Pro 
 225                230                235                240
Phe Lys Leu Leu Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                 245                250                255
Trp Gly Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
             260                265                270
Asp Val Ser Arg Ser Ile Gly Leu Phe Phe Val Ser Tyr Phe His Cys 
         275                280                285
Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Ser Tyr Val Met Leu 
     290                295                300
Ala Ser Ser Pro Leu Phe Cys Ser Pro Glu Trp Pro Arg Lys Leu Val 
 305                310                315                320
Ser Tyr Cys Pro Gln Arg Leu Gln Gln Leu Leu Pro Leu Lys Ala Ala 
                 325                330                335
Pro Gln Pro Ser Val Ser Cys Val Tyr Lys Arg Ser Arg Gly Lys Ser 
             340                345                350
Gly Gln Lys Pro Gly Leu Arg His Gln Leu Gly Ala Ala Phe Thr Leu 
         355                360                365
Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
     370                375                380
Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
 385                390                395                400
Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                 405                410                415
Asp Gly Arg Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
             420                425                430
Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
         435                440                445
Thr Cys Leu Ser Arg Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
     450                455                460
Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
 465                470                475                480
Ile Phe Asp Pro Arg Val Asp Ile Val Gln Ala Ala Trp Ser Pro Phe 
                 485                490                495
Gln Arg Thr Ser Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
             500                505                510
Arg Ala Lys Leu Gln Glu Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
         515                520                525
Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
     530                535                540
Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
 545                550                555                560
Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                 565                570                575
Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Thr 
             580                585                590
Ser Pro Ser Pro Ser Cys Tyr Met Tyr Val Tyr Val Asn Thr Thr Glu 
         595                600                605
Leu Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
     610                615                620
Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
 625                630                635                640
Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                 645                650                655
Gln Thr Phe Leu Arg Arg Gln Gln Arg Leu Gln Glu Ile Glu Arg Arg 
             660                665                670
Arg Asn Thr Pro Phe His Glu Arg Phe Phe Arg Phe Leu Leu Arg Lys 
         675                680                685
Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Cys Ile Ser Leu Arg 
     690                695                700
Asn Leu Ile Leu Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
 705                710                715                720
Thr Tyr Ala Asn Leu Arg Pro Phe Glu Ala Val Gly Glu Leu Asn Pro 
                 725                730                735
Ser Asn Thr Asp Ser Ser His Ser Asn Pro Pro Glu Ser Asn Pro Asp 
             740                745                750
Pro Val His Ser Glu Phe 
         755



<210> 1026
<211> 2151
<212> DNA
<213> Rattus norvegicus
<308> AF065438
<400> 1026

ggaaaacac  tggtggggc  tttctcagc  gaacagtct  cagaaagct  cgagctgca  60
ccagcaagg  ggctccagg  ccatctgca  cagctgcct  gacaggtga  tgactacct  120
tctcttgct  ccaggttgg  cttccaggt  aggcaatgg  tcttctgtg  ctcctctct  180
tgttcttgc  ggttccagg  actcaaggt  caaaggatg  agacatgcg  ctggttaat  240
gggcctcag  cagtgaggg  cgcgtggag  tcttctaca  aggccggtg  gggacagtg  300
gcgacaacc  ctggaacct  ttggatgcc  acgtcgtct  ccgggccct  ggctatgag  360
atgctactc  agcactgag  agagccgcc  tcgggccag  aaagggacc  atcatgctg  420
atgaggtgg  atgcacagg  aacgagtcg  cactggcca  ttgcagctc  ctgggctgg  480
tggtgagcc  ctgcgggca  gagaaggac  cgggcgtgg  ctgctccaa  gattccagg  540
gcattcaca  cctagacct  tctggagag  tcccagatg  gctgggcca  atctttgac  600
gccagcagg  ctgcgacct  ttcatccag  tgacagggc  gggacatgg  gacctgagc  660
tctgtgccc  cacactgat  ctgcgcacc  accccgagg  ccaggccct  tggcaagtg  720
tgggcagca  tgtcatcat  agagtggac  ctgagtgca  gcctgtcgt  agagacttc  780
tcaggtact  ttactcccg  agaatcgag  tcagcatgt  ttctgtcaa  tgtctgcac  840
agctggcct  cgcctatgg  gccacagag  tccagggtt  ctgtggacg  ctttttgtc  900
ccctcctcc  ccaggaccc  actttccat  cgcccctgg  actttacga  tatgcgcag  960
ccaccgggg  ctctgtgct  gaagatctg  gtgtgcaat  cctggcctg  aacttcgag  1020
ctctgacac  ggccgaggc  tggttgtct  ttcccaatg  cttgatcca  gctctcctc  1080
ccaagagcg  gctggctgt  tccagtgaa  tggatttgc  gaaggcagt  gaccagtgg  1140
gcacagcga  cggcgcctc  cacggggat  tagagcgcc  ggtggaaca  atccgcttt  1200
ctatgatgc  gccccagga  ctgtttgag  tacagttca  cctgtcctt  taccaaggt  1260
accaggccc  gttccagag  aagaccatg  aggccctgg  gttccacac  gtgcctctc  1320
aagtgctgg  caagtacag  agcctgaac  tcaccgagg  tgtctacaa  ccccggctt  1380
acacctctt  tacctggag  agcctgctg  tggccggtg  ctggagtac  caaagctac  1440
aatacagac  gttctacac  tacaactat  gctcacaat  ccgctacag  agctaccag  1500
acttccaga  cccacaaca  cccagcttc  tcttcaagg  caagctgat  tcctggtca  1560
ccacctacc  ccccaccat  cagagttgc  ggaactatg  cttctcgtg  acctctgac  1620
agctccctg  actgggcct  accacatcc  gttactccg  tccaactat  ggctacgag  1680
acaaagcgc  gatcctctg  ggaggctac  gtgtggtag  tgtcaccac  tttataggc  1740
ctaaggccc  tattccagg  acccaggag  ccaatagtt  caagacccc  tccctcttt  1800
cctgtgcct  aggggcctt  agcagcttc  gcgaggtca  ccgcccctt  tacctcacc  1860
actccactg  cacggagta  atggtacat  tcagcggtg  ggactcaga  attcctgtg  1920
tccctcctt  gcctccagc  tctctgtag  aacctccag  agcctgcca  cagatttcc  1980
ttagcttcc  ctgtctcca  gagctttaa  atgtactag  aggtttcag  cagtactca  2040
tccagatct  agagtctca  ggcccccaa  tgtaggcac  aggaggtcc  gtgggattc  2100
ccatcagtc  cagtcacta  tctgaaatc  ttaaagtgg  acgtgcttc  c  2151



<210> 1027
<211> 574
<212> PRT
<213> Rattus norvegicus
<308> AAC17177
<400> 1027

Met Ala Leu Leu Trp Leu Leu Ser Val Phe Leu Leu Val Pro Gly Thr 
  1               5                  10                  15
Gln Gly Ala Lys Asp Gly Asp Met Arg Leu Val Asn Gly Ala Ser Ala 
             20                  25                  30
Ser Glu Gly Arg Val Glu Ile Phe Tyr Arg Gly Arg Trp Gly Thr Val 
         35                  40                  45
Cys Asp Asn Leu Trp Asn Leu Leu Asp Ala His Val Val Cys Arg Ala 
     50                  55                  60
Leu Gly Tyr Glu Asn Ala Thr Gln Ala Leu Ser Arg Ala Ala Phe Gly 
 65                  70                  75                  80
Pro Gly Lys Gly Pro Ile Met Leu Asp Glu Val Glu Cys Thr Gly Asn 
                 85                  90                  95
Glu Ser Ser Leu Ala Asn Cys Ser Ser Leu Gly Trp Met Val Ser His 
             100                105                110
Cys Gly His Glu Lys Asp Ala Gly Val Val Cys Ser Asn Asp Ser Arg 
         115                120                125
Gly Ile His Ile Leu Asp Leu Ser Gly Glu Leu Pro Asp Ala Leu Gly 
     130                135                140
Gln Ile Phe Asp Ser Gln Gln Asp Cys Asp Leu Phe Ile Gln Val Thr 
 145                150                155                160
Gly Gln Gly His Gly Asp Leu Ser Leu Cys Ala His Thr Leu Ile Leu 
                 165                170                175
Arg Thr Asn Pro Glu Ala Gln Ala Leu Trp Gln Val Val Gly Ser Ser 
             180                185                190
Val Ile Met Arg Val Asp Ala Glu Cys Met Pro Val Val Arg Asp Phe 
         195                200                205
Leu Arg Tyr Phe Tyr Ser Arg Arg Ile Glu Val Ser Met Ser Ser Val 
     210                215                220
Lys Cys Leu His Lys Leu Ala Ser Ala Tyr Gly Ala Thr Glu Leu Gln 
 225                230                235                240
Gly Tyr Cys Gly Arg Leu Phe Val Thr Leu Leu Pro Gln Asp Pro Thr 
                 245                250                255
Phe His Thr Pro Leu Glu Leu Tyr Glu Tyr Ala Gln Ala Thr Gly Asp 
             260                265                270
Ser Val Leu Glu Asp Leu Cys Val Gln Phe Leu Ala Trp Asn Phe Glu 
         275                280                285
Pro Leu Thr Gln Ala Glu Ala Trp Leu Ser Val Pro Asn Ala Leu Ile 
     290                295                300
Gln Ala Leu Leu Pro Lys Ser Glu Leu Ala Val Ser Ser Glu Leu Asp 
 305                310                315                320
Leu Leu Lys Ala Val Asp Gln Trp Ser Thr Ala Thr Gly Ala Ser His 
                 325                330                335
Gly Asp Val Glu Arg Leu Val Glu Gln Ile Arg Phe Pro Met Met Leu 
             340                345                350
Pro Gln Glu Leu Phe Glu Leu Gln Phe Asn Leu Ser Leu Tyr Gln Gly 
         355                360                365
His Gln Ala Leu Phe Gln Arg Lys Thr Met Glu Ala Leu Glu Phe His 
     370                375                380
Thr Val Pro Leu Lys Val Leu Ala Lys Tyr Arg Ser Leu Asn Leu Thr 
 385                390                395                400
Glu Asp Val Tyr Lys Pro Arg Leu Tyr Thr Ser Ser Thr Trp Ser Ser 
                 405                410                415
Leu Leu Met Ala Gly Ala Trp Ser Thr Gln Ser Tyr Lys Tyr Arg Gln 
             420                425                430
Phe Tyr Thr Tyr Asn Tyr Gly Ser Gln Ser Arg Tyr Ser Ser Tyr Gln 
         435                440                445
Asn Phe Gln Thr Pro Gln His Pro Ser Phe Leu Phe Lys Asp Lys Leu 
     450                455                460
Ile Ser Trp Ser Ala Thr Tyr Leu Pro Thr Ile Gln Ser Cys Trp Asn 
 465                470                475                480
Tyr Gly Phe Ser Cys Thr Ser Asp Glu Leu Pro Val Leu Gly Leu Thr 
                 485                490                495
Thr Ser Ser Tyr Ser Asp Pro Thr Ile Gly Tyr Glu Asn Lys Ala Leu 
             500                505                510
Ile Leu Cys Gly Gly Tyr Ser Val Val Asp Val Thr Thr Phe Ile Gly 
         515                520                525
Ser Lys Ala Pro Ile Pro Gly Thr Gln Glu Thr Asn Ser Ser Lys Thr 
     530                535                540
Pro Ser Leu Phe Pro Cys Ala Ser Gly Ala Phe Ser Ser Phe Arg Glu 
 545                550                555                560
Val Ile Arg Pro Phe Tyr Leu Thr Asn Ser Thr Asp Thr Glu 
                 565                570



<210> 1028
<211> 2254
<212> DNA
<213> Homo sapiens
<308> NM_005567
<400> 1028

aatcgaaag  agactcttt  ctgaagcat  tcctgggat  agcctgacc  cgctccata  60
tgggagagg  ttctgggtc  aaggaccag  ctgcagagg  atcctgtgg  tggaagcga  120
gaggctcca  acggccgtt  cagctaccg  agccaggat  tgggcatcc  ggcacggcc  180
tgacccctc  gaggctctt  tgggtgtgg  tgctggttg  aggaaccca  ggcgtgaac  240
atggtgaca  gcggctggc  gatgggggc  ccaccaacc  gggccgcgt  gagatcttc  300
acagaggcc  gtggggcac  gtgtgtgac  acctgtggg  cctgactga  gccagcgtc  360
tctgccggg  cctgggctt  gagaacgcc  cccaggctc  gggcagagc  gccttcggg  420
aaggatcag  ccccatcat  ctggacgag  tccagtgca  gggaaccga  gcctcactg  480
ccgactgca  gtccctggg  tggctgaag  gcaactgca  gcacgagag  gacgctggt  540
tggtctgca  caatgaaac  aggagcacc  acaccctgg  cctctccag  gagctctcg  600
aggcccttg  ccagatctt  gacagccag  ggggctgcg  cctgtccat  agcgtgaat  660
tgcagggcg  ggacgccct  ggcttctgt  gccacacgg  catcctgac  gccaacctg  720
aggcccagg  cctgtggaa  gagccgggc  gcaatgtca  catgagtgt  gatgctgag  780
gtgtgccca  ggtcaggga  cttctcagg  acttctact  ccgaaggat  gacatcacc  840
tgtcgtcag  caagtgctt  cacaagctg  cctctgcct  tggggccag  cagctgcag  900
gctactgcg  aagcctctt  gccatcctc  tcccccagg  cccctcgtt  cagatgccc  960
tggacctgt  tgcctatgc  gtggccaca  gggacgccc  gctggagaa  ctctgccta  1020
agttcctgg  ctggaactt  gaggccttg  cgcaggccg  ggcctggcc  agtgtcccc  1080
cagacctgc  ccaactgct  ctgcccagg  gcgacctgg  ggtgcccag  gagctggcc  1140
tactgaagg  cgtggacac  tggagctgg  gggagcgtg  ctcccatga  gaggtggag  1200
gcttggtgg  gaagatccg  ttccccatg  tgctccctg  ggagctctt  gagctgcag  1260
tcaacctgt  cctgtactg  agccacgag  ccctgttcc  gaagaagac  ctgcaggcc  1320
tggaattcc  cactgtgcc  ttccagttg  tggcccggt  caaaggcct  aacctcacc  1380
aggatacct  caagccccg  atttacacc  cgcccacct  gagtgcctt  gtgacagac  1440
gttcctgga  tgcacggaa  tcacaactg  tctatcagt  cagacgggg  cctttggtc  1500
aatattctt  tgattactt  caagccccc  ctgactaca  atactaccc  taccagtcc  1560
tccagactc  acaacaccc  agcttcctc  tccaggaca  gagggtgtc  tggtccctg  1620
tctacctcc  caccatcca  agctgctgg  actacggct  ctcctgctc  tcggacgag  1680
tccctgtcc  gggcctcac  aagtctggc  gctcagatc  caccattgc  tacgaaaac  1740
aagccctga  gctctgcga  gggctcttc  tggcagacg  caccgattt  gagggctgg  1800
aggctgcga  tcccagtgc  ctggacacc  acagctcga  gagcacctc  tccttcccc  1860
gcccggcag  gcacttcaa  ggcttccgc  cggtcatcc  ccccttcta  ctgaccaac  1920
cctcaggtg  ggactagac  cgtggccaa  ggtggtgag  accggagaa  cccaggacg  1980
cctcactgc  ggctcccct  ctcggcttc  ttcctctct  caatgacct  caacaaccg  2040
ccaccagat  tcgccctac  cacctgagg  tcagcttca  gaaattact  gaaggcttc  2100
actagggtc  accaggagt  ctcccacca  ctcaccagt  tccaggtgg  aagcaccag  2160
aggccctcg  ggttgctct  gatcccccc  cagcccctg  tcagtctgc  cttgtcact  2220
gtctgaggt  attaaaatt  cattgaggt  ccta  2254



<210> 1029
<211> 585
<212> PRT
<213> Homo sapiens
<308> NP_005558
<400> 1029

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
  1               5                  10                  15
Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
             20                  25                  30
Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
         35                  40                  45
Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
     50                  55                  60
Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
 65                  70                  75                  80
Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr 
                 85                  90                  95
Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn 
             100                105                110
Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Glu Thr Arg 
         115                120                125
Ser Thr His Thr Leu Asp Leu Ser Arg Glu Leu Ser Glu Ala Leu Gly 
     130                135                140
Gln Ile Phe Asp Ser Gln Arg Gly Cys Asp Leu Ser Ile Ser Val Asn 
 145                150                155                160
Val Gln Gly Glu Asp Ala Leu Gly Phe Cys Gly His Thr Val Ile Leu 
                 165                170                175
Thr Ala Asn Leu Glu Ala Gln Ala Leu Trp Lys Glu Pro Gly Ser Asn 
             180                185                190
Val Thr Met Ser Val Asp Ala Glu Cys Val Pro Met Val Arg Asp Leu 
         195                200                205
Leu Arg Tyr Phe Tyr Ser Arg Arg Ile Asp Ile Thr Leu Ser Ser Val 
     210                215                220
Lys Cys Phe His Lys Leu Ala Ser Ala Tyr Gly Ala Arg Gln Leu Gln 
 225                230                235                240
Gly Tyr Cys Ala Ser Leu Phe Ala Ile Leu Leu Pro Gln Asp Pro Ser 
                 245                250                255
Phe Gln Met Pro Leu Asp Leu Tyr Ala Tyr Ala Val Ala Thr Gly Asp 
             260                265                270
Ala Leu Leu Glu Lys Leu Cys Leu Gln Phe Leu Ala Trp Asn Phe Glu 
         275                280                285
Ala Leu Thr Gln Ala Glu Ala Trp Pro Ser Val Pro Thr Asp Leu Leu 
     290                295                300
Gln Leu Leu Leu Pro Arg Ser Asp Leu Ala Val Pro Ser Glu Leu Ala 
 305                310                315                320
Leu Leu Lys Ala Val Asp Thr Trp Ser Trp Gly Glu Arg Ala Ser His 
                 325                330                335
Glu Glu Val Glu Gly Leu Val Glu Lys Ile Arg Phe Pro Met Met Leu 
             340                345                350
Pro Glu Glu Leu Phe Glu Leu Gln Phe Asn Leu Ser Leu Tyr Trp Ser 
         355                360                365
His Glu Ala Leu Phe Gln Lys Lys Thr Leu Gln Ala Leu Glu Phe His 
     370                375                380
Thr Val Pro Phe Gln Leu Leu Ala Arg Tyr Lys Gly Leu Asn Leu Thr 
 385                390                395                400
Glu Asp Thr Tyr Lys Pro Arg Ile Tyr Thr Ser Pro Thr Trp Ser Ala 
                 405                410                415
Phe Val Thr Asp Ser Ser Trp Ser Ala Arg Lys Ser Gln Leu Val Tyr 
             420                425                430
Gln Ser Arg Arg Gly Pro Leu Val Lys Tyr Ser Ser Asp Tyr Phe Gln 
         435                440                445
Ala Pro Ser Asp Tyr Arg Tyr Tyr Pro Tyr Gln Ser Phe Gln Thr Pro 
     450                455                460
Gln His Pro Ser Phe Leu Phe Gln Asp Lys Arg Val Ser Trp Ser Leu 
 465                470                475                480
Val Tyr Leu Pro Thr Ile Gln Ser Cys Trp Asn Tyr Gly Phe Ser Cys 
                 485                490                495
Ser Ser Asp Glu Leu Pro Val Leu Gly Leu Thr Lys Ser Gly Gly Ser 
             500                505                510
Asp Arg Thr Ile Ala Tyr Glu Asn Lys Ala Leu Met Leu Cys Glu Gly 
         515                520                525
Leu Phe Val Ala Asp Val Thr Asp Phe Glu Gly Trp Lys Ala Ala Ile 
     530                535                540
Pro Ser Ala Leu Asp Thr Asn Ser Ser Lys Ser Thr Ser Ser Phe Pro 
 545                550                555                560
Cys Pro Ala Gly His Phe Asn Gly Phe Arg Thr Val Ile Arg Pro Phe 
                 565                570                575
Tyr Leu Thr Asn Ser Ser Gly Val Asp 
             580                585



<210> 1030
<211> 2151
<212> DNA
<213> Rattus norvegicus
<308> AF065438
<400> 1030

ggaaaacac  tggtggggc  tttctcagc  gaacagtct  cagaaagct  cgagctgca  60
ccagcaagg  ggctccagg  ccatctgca  cagctgcct  gacaggtga  tgactacct  120
tctcttgct  ccaggttgg  cttccaggt  aggcaatgg  tcttctgtg  ctcctctct  180
tgttcttgc  ggttccagg  actcaaggt  caaaggatg  agacatgcg  ctggttaat  240
gggcctcag  cagtgaggg  cgcgtggag  tcttctaca  aggccggtg  gggacagtg  300
gcgacaacc  ctggaacct  ttggatgcc  acgtcgtct  ccgggccct  ggctatgag  360
atgctactc  agcactgag  agagccgcc  tcgggccag  aaagggacc  atcatgctg  420
atgaggtgg  atgcacagg  aacgagtcg  cactggcca  ttgcagctc  ctgggctgg  480
tggtgagcc  ctgcgggca  gagaaggac  cgggcgtgg  ctgctccaa  gattccagg  540
gcattcaca  cctagacct  tctggagag  tcccagatg  gctgggcca  atctttgac  600
gccagcagg  ctgcgacct  ttcatccag  tgacagggc  gggacatgg  gacctgagc  660
tctgtgccc  cacactgat  ctgcgcacc  accccgagg  ccaggccct  tggcaagtg  720
tgggcagca  tgtcatcat  agagtggac  ctgagtgca  gcctgtcgt  agagacttc  780
tcaggtact  ttactcccg  agaatcgag  tcagcatgt  ttctgtcaa  tgtctgcac  840
agctggcct  cgcctatgg  gccacagag  tccagggtt  ctgtggacg  ctttttgtc  900
ccctcctcc  ccaggaccc  actttccat  cgcccctgg  actttacga  tatgcgcag  960
ccaccgggg  ctctgtgct  gaagatctg  gtgtgcaat  cctggcctg  aacttcgag  1020
ctctgacac  ggccgaggc  tggttgtct  ttcccaatg  cttgatcca  gctctcctc  1080
ccaagagcg  gctggctgt  tccagtgaa  tggatttgc  gaaggcagt  gaccagtgg  1140
gcacagcga  cggcgcctc  cacggggat  tagagcgcc  ggtggaaca  atccgcttt  1200
ctatgatgc  gccccagga  ctgtttgag  tacagttca  cctgtcctt  taccaaggt  1260
accaggccc  gttccagag  aagaccatg  aggccctgg  gttccacac  gtgcctctc  1320
aagtgctgg  caagtacag  agcctgaac  tcaccgagg  tgtctacaa  ccccggctt  1380
acacctctt  tacctggag  agcctgctg  tggccggtg  ctggagtac  caaagctac  1440
aatacagac  gttctacac  tacaactat  gctcacaat  ccgctacag  agctaccag  1500
acttccaga  cccacaaca  cccagcttc  tcttcaagg  caagctgat  tcctggtca  1560
ccacctacc  ccccaccat  cagagttgc  ggaactatg  cttctcgtg  acctctgac  1620
agctccctg  actgggcct  accacatcc  gttactccg  tccaactat  ggctacgag  1680
acaaagcgc  gatcctctg  ggaggctac  gtgtggtag  tgtcaccac  tttataggc  1740
ctaaggccc  tattccagg  acccaggag  ccaatagtt  caagacccc  tccctcttt  1800
cctgtgcct  aggggcctt  agcagcttc  gcgaggtca  ccgcccctt  tacctcacc  1860
actccactg  cacggagta  atggtacat  tcagcggtg  ggactcaga  attcctgtg  1920
tccctcctt  gcctccagc  tctctgtag  aacctccag  agcctgcca  cagatttcc  1980
ttagcttcc  ctgtctcca  gagctttaa  atgtactag  aggtttcag  cagtactca  2040
tccagatct  agagtctca  ggcccccaa  tgtaggcac  aggaggtcc  gtgggattc  2100
ccatcagtc  cagtcacta  tctgaaatc  ttaaagtgg  acgtgcttc  c  2151



<210> 1031
<211> 574
<212> PRT
<213> Rattus norvegicus
<308> AAC17177
<400> 1031

Met Ala Leu Leu Trp Leu Leu Ser Val Phe Leu Leu Val Pro Gly Thr 
  1               5                  10                  15
Gln Gly Ala Lys Asp Gly Asp Met Arg Leu Val Asn Gly Ala Ser Ala 
             20                  25                  30
Ser Glu Gly Arg Val Glu Ile Phe Tyr Arg Gly Arg Trp Gly Thr Val 
         35                  40                  45
Cys Asp Asn Leu Trp Asn Leu Leu Asp Ala His Val Val Cys Arg Ala 
     50                  55                  60
Leu Gly Tyr Glu Asn Ala Thr Gln Ala Leu Ser Arg Ala Ala Phe Gly 
 65                  70                  75                  80
Pro Gly Lys Gly Pro Ile Met Leu Asp Glu Val Glu Cys Thr Gly Asn 
                 85                  90                  95
Glu Ser Ser Leu Ala Asn Cys Ser Ser Leu Gly Trp Met Val Ser His 
             100                105                110
Cys Gly His Glu Lys Asp Ala Gly Val Val Cys Ser Asn Asp Ser Arg 
         115                120                125
Gly Ile His Ile Leu Asp Leu Ser Gly Glu Leu Pro Asp Ala Leu Gly 
     130                135                140
Gln Ile Phe Asp Ser Gln Gln Asp Cys Asp Leu Phe Ile Gln Val Thr 
 145                150                155                160
Gly Gln Gly His Gly Asp Leu Ser Leu Cys Ala His Thr Leu Ile Leu 
                 165                170                175
Arg Thr Asn Pro Glu Ala Gln Ala Leu Trp Gln Val Val Gly Ser Ser 
             180                185                190
Val Ile Met Arg Val Asp Ala Glu Cys Met Pro Val Val Arg Asp Phe 
         195                200                205
Leu Arg Tyr Phe Tyr Ser Arg Arg Ile Glu Val Ser Met Ser Ser Val 
     210                215                220
Lys Cys Leu His Lys Leu Ala Ser Ala Tyr Gly Ala Thr Glu Leu Gln 
 225                230                235                240
Gly Tyr Cys Gly Arg Leu Phe Val Thr Leu Leu Pro Gln Asp Pro Thr 
                 245                250                255
Phe His Thr Pro Leu Glu Leu Tyr Glu Tyr Ala Gln Ala Thr Gly Asp 
             260                265                270
Ser Val Leu Glu Asp Leu Cys Val Gln Phe Leu Ala Trp Asn Phe Glu 
         275                280                285
Pro Leu Thr Gln Ala Glu Ala Trp Leu Ser Val Pro Asn Ala Leu Ile 
     290                295                300
Gln Ala Leu Leu Pro Lys Ser Glu Leu Ala Val Ser Ser Glu Leu Asp 
 305                310                315                320
Leu Leu Lys Ala Val Asp Gln Trp Ser Thr Ala Thr Gly Ala Ser His 
                 325                330                335
Gly Asp Val Glu Arg Leu Val Glu Gln Ile Arg Phe Pro Met Met Leu 
             340                345                350
Pro Gln Glu Leu Phe Glu Leu Gln Phe Asn Leu Ser Leu Tyr Gln Gly 
         355                360                365
His Gln Ala Leu Phe Gln Arg Lys Thr Met Glu Ala Leu Glu Phe His 
     370                375                380
Thr Val Pro Leu Lys Val Leu Ala Lys Tyr Arg Ser Leu Asn Leu Thr 
 385                390                395                400
Glu Asp Val Tyr Lys Pro Arg Leu Tyr Thr Ser Ser Thr Trp Ser Ser 
                 405                410                415
Leu Leu Met Ala Gly Ala Trp Ser Thr Gln Ser Tyr Lys Tyr Arg Gln 
             420                425                430
Phe Tyr Thr Tyr Asn Tyr Gly Ser Gln Ser Arg Tyr Ser Ser Tyr Gln 
         435                440                445
Asn Phe Gln Thr Pro Gln His Pro Ser Phe Leu Phe Lys Asp Lys Leu 
     450                455                460
Ile Ser Trp Ser Ala Thr Tyr Leu Pro Thr Ile Gln Ser Cys Trp Asn 
 465                470                475                480
Tyr Gly Phe Ser Cys Thr Ser Asp Glu Leu Pro Val Leu Gly Leu Thr 
                 485                490                495
Thr Ser Ser Tyr Ser Asp Pro Thr Ile Gly Tyr Glu Asn Lys Ala Leu 
             500                505                510
Ile Leu Cys Gly Gly Tyr Ser Val Val Asp Val Thr Thr Phe Ile Gly 
         515                520                525
Ser Lys Ala Pro Ile Pro Gly Thr Gln Glu Thr Asn Ser Ser Lys Thr 
     530                535                540
Pro Ser Leu Phe Pro Cys Ala Ser Gly Ala Phe Ser Ser Phe Arg Glu 
 545                550                555                560
Val Ile Arg Pro Phe Tyr Leu Thr Asn Ser Thr Asp Thr Glu 
                 565                570



<210> 1032
<211> 2254
<212> DNA
<213> Homo sapiens
<308> NM_005567
<400> 1032

aatcgaaag  agactcttt  ctgaagcat  tcctgggat  agcctgacc  cgctccata  60
tgggagagg  ttctgggtc  aaggaccag  ctgcagagg  atcctgtgg  tggaagcga  120
gaggctcca  acggccgtt  cagctaccg  agccaggat  tgggcatcc  ggcacggcc  180
tgacccctc  gaggctctt  tgggtgtgg  tgctggttg  aggaaccca  ggcgtgaac  240
atggtgaca  gcggctggc  gatgggggc  ccaccaacc  gggccgcgt  gagatcttc  300
acagaggcc  gtggggcac  gtgtgtgac  acctgtggg  cctgactga  gccagcgtc  360
tctgccggg  cctgggctt  gagaacgcc  cccaggctc  gggcagagc  gccttcggg  420
aaggatcag  ccccatcat  ctggacgag  tccagtgca  gggaaccga  gcctcactg  480
ccgactgca  gtccctggg  tggctgaag  gcaactgca  gcacgagag  gacgctggt  540
tggtctgca  caatgaaac  aggagcacc  acaccctgg  cctctccag  gagctctcg  600
aggcccttg  ccagatctt  gacagccag  ggggctgcg  cctgtccat  agcgtgaat  660
tgcagggcg  ggacgccct  ggcttctgt  gccacacgg  catcctgac  gccaacctg  720
aggcccagg  cctgtggaa  gagccgggc  gcaatgtca  catgagtgt  gatgctgag  780
gtgtgccca  ggtcaggga  cttctcagg  acttctact  ccgaaggat  gacatcacc  840
tgtcgtcag  caagtgctt  cacaagctg  cctctgcct  tggggccag  cagctgcag  900
gctactgcg  aagcctctt  gccatcctc  tcccccagg  cccctcgtt  cagatgccc  960
tggacctgt  tgcctatgc  gtggccaca  gggacgccc  gctggagaa  ctctgccta  1020
agttcctgg  ctggaactt  gaggccttg  cgcaggccg  ggcctggcc  agtgtcccc  1080
cagacctgc  ccaactgct  ctgcccagg  gcgacctgg  ggtgcccag  gagctggcc  1140
tactgaagg  cgtggacac  tggagctgg  gggagcgtg  ctcccatga  gaggtggag  1200
gcttggtgg  gaagatccg  ttccccatg  tgctccctg  ggagctctt  gagctgcag  1260
tcaacctgt  cctgtactg  agccacgag  ccctgttcc  gaagaagac  ctgcaggcc  1320
tggaattcc  cactgtgcc  ttccagttg  tggcccggt  caaaggcct  aacctcacc  1380
aggatacct  caagccccg  atttacacc  cgcccacct  gagtgcctt  gtgacagac  1440
gttcctgga  tgcacggaa  tcacaactg  tctatcagt  cagacgggg  cctttggtc  1500
aatattctt  tgattactt  caagccccc  ctgactaca  atactaccc  taccagtcc  1560
tccagactc  acaacaccc  agcttcctc  tccaggaca  gagggtgtc  tggtccctg  1620
tctacctcc  caccatcca  agctgctgg  actacggct  ctcctgctc  tcggacgag  1680
tccctgtcc  gggcctcac  aagtctggc  gctcagatc  caccattgc  tacgaaaac  1740
aagccctga  gctctgcga  gggctcttc  tggcagacg  caccgattt  gagggctgg  1800
aggctgcga  tcccagtgc  ctggacacc  acagctcga  gagcacctc  tccttcccc  1860
gcccggcag  gcacttcaa  ggcttccgc  cggtcatcc  ccccttcta  ctgaccaac  1920
cctcaggtg  ggactagac  cgtggccaa  ggtggtgag  accggagaa  cccaggacg  1980
cctcactgc  ggctcccct  ctcggcttc  ttcctctct  caatgacct  caacaaccg  2040
ccaccagat  tcgccctac  cacctgagg  tcagcttca  gaaattact  gaaggcttc  2100
actagggtc  accaggagt  ctcccacca  ctcaccagt  tccaggtgg  aagcaccag  2160
aggccctcg  ggttgctct  gatcccccc  cagcccctg  tcagtctgc  cttgtcact  2220
gtctgaggt  attaaaatt  cattgaggt  ccta  2254



<210> 1033
<211> 585
<212> PRT
<213> Homo sapiens
<308> NP_005558
<400> 1033

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
  1               5                  10                  15
Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
             20                  25                  30
Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
         35                  40                  45
Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
     50                  55                  60
Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
 65                  70                  75                  80
Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr 
                 85                  90                  95
Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn 
             100                105                110
Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Glu Thr Arg 
         115                120                125
Ser Thr His Thr Leu Asp Leu Ser Arg Glu Leu Ser Glu Ala Leu Gly 
     130                135                140
Gln Ile Phe Asp Ser Gln Arg Gly Cys Asp Leu Ser Ile Ser Val Asn 
 145                150                155                160
Val Gln Gly Glu Asp Ala Leu Gly Phe Cys Gly His Thr Val Ile Leu 
                 165                170                175
Thr Ala Asn Leu Glu Ala Gln Ala Leu Trp Lys Glu Pro Gly Ser Asn 
             180                185                190
Val Thr Met Ser Val Asp Ala Glu Cys Val Pro Met Val Arg Asp Leu 
         195                200                205
Leu Arg Tyr Phe Tyr Ser Arg Arg Ile Asp Ile Thr Leu Ser Ser Val 
     210                215                220
Lys Cys Phe His Lys Leu Ala Ser Ala Tyr Gly Ala Arg Gln Leu Gln 
 225                230                235                240
Gly Tyr Cys Ala Ser Leu Phe Ala Ile Leu Leu Pro Gln Asp Pro Ser 
                 245                250                255
Phe Gln Met Pro Leu Asp Leu Tyr Ala Tyr Ala Val Ala Thr Gly Asp 
             260                265                270
Ala Leu Leu Glu Lys Leu Cys Leu Gln Phe Leu Ala Trp Asn Phe Glu 
         275                280                285
Ala Leu Thr Gln Ala Glu Ala Trp Pro Ser Val Pro Thr Asp Leu Leu 
     290                295                300
Gln Leu Leu Leu Pro Arg Ser Asp Leu Ala Val Pro Ser Glu Leu Ala 
 305                310                315                320
Leu Leu Lys Ala Val Asp Thr Trp Ser Trp Gly Glu Arg Ala Ser His 
                 325                330                335
Glu Glu Val Glu Gly Leu Val Glu Lys Ile Arg Phe Pro Met Met Leu 
             340                345                350
Pro Glu Glu Leu Phe Glu Leu Gln Phe Asn Leu Ser Leu Tyr Trp Ser 
         355                360                365
His Glu Ala Leu Phe Gln Lys Lys Thr Leu Gln Ala Leu Glu Phe His 
     370                375                380
Thr Val Pro Phe Gln Leu Leu Ala Arg Tyr Lys Gly Leu Asn Leu Thr 
 385                390                395                400
Glu Asp Thr Tyr Lys Pro Arg Ile Tyr Thr Ser Pro Thr Trp Ser Ala 
                 405                410                415
Phe Val Thr Asp Ser Ser Trp Ser Ala Arg Lys Ser Gln Leu Val Tyr 
             420                425                430
Gln Ser Arg Arg Gly Pro Leu Val Lys Tyr Ser Ser Asp Tyr Phe Gln 
         435                440                445
Ala Pro Ser Asp Tyr Arg Tyr Tyr Pro Tyr Gln Ser Phe Gln Thr Pro 
     450                455                460
Gln His Pro Ser Phe Leu Phe Gln Asp Lys Arg Val Ser Trp Ser Leu 
 465                470                475                480
Val Tyr Leu Pro Thr Ile Gln Ser Cys Trp Asn Tyr Gly Phe Ser Cys 
                 485                490                495
Ser Ser Asp Glu Leu Pro Val Leu Gly Leu Thr Lys Ser Gly Gly Ser 
             500                505                510
Asp Arg Thr Ile Ala Tyr Glu Asn Lys Ala Leu Met Leu Cys Glu Gly 
         515                520                525
Leu Phe Val Ala Asp Val Thr Asp Phe Glu Gly Trp Lys Ala Ala Ile 
     530                535                540
Pro Ser Ala Leu Asp Thr Asn Ser Ser Lys Ser Thr Ser Ser Phe Pro 
 545                550                555                560
Cys Pro Ala Gly His Phe Asn Gly Phe Arg Thr Val Ile Arg Pro Phe 
                 565                570                575
Tyr Leu Thr Asn Ser Ser Gly Val Asp 
             580                585



<210> 1034
<211> 1099
<212> DNA
<213> Rattus norvegicus
<308> AF067790
<400> 1034

cgcagggat  tgagcagca  atcgttggg  ttgctcagg  tttcagact  gtggaaatc  60
tgtggtgag  ccttgaagc  tacgggggc  ccacgccca  agaaggtgg  agcatgccg  120
ggctatgga  gcagaggct  ccttcggct  gggctttgc  tctcctgcc  ttcctgccg  180
tgctgttgc  cgcagcccc  gcaccccac  gcgggtcct  caagccagt  atcgtggtg  240
atgggctct  tgacagttc  tacagcttc  gccacctgc  ggactacat  aatgagaca  300
accccggga  tgtggtgac  gtgcttgat  tcttcgatg  cagagagag  ttgcgaccc  360
tgtgggaac  ggttcaagg  ttccgagag  ctgtggtcc  catcatgga  aaggcccct  420
agggggtac  cctcatctg  tactcccag  gaggcctgg  gtgccgcgc  ttgctgtct  480
tcatggatg  gcacaatgt  gattccttc  tctcccttt  ttctccaca  atgggacag  540
atggagaca  ggactattt  aagtggctg  tccctttct  ccatggctg  ggttgggaa  600
caagcacca  gtttttaac  gtggcttca  cgctgctgc  gttgcttct  cgggtctgg  660
tgtaccgga  gagaaccca  cccctgccc  cctcagggg  cttccaggc  actcaggac  720
tttttagct  gttattccc  tgcccctct  ttctgtccc  gtggccagc  tccccaccg  780
gaggggcgc  cgtacaagg  ggttctgag  ctcccctat  gggacagtt  cacttttga  840
gtgtcagtg  tggggaata  ctgtggcct  caaggccca  ctcaggttt  gggatcccc  900
agtccctat  atcagtgtt  gggtatccc  tgggagcct  ggttctttg  ggccccagc  960
cctctttta  ccacccttg  gtgggtggt  cccgtattt  tagaaataa  agttccatt  1020
cctcaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1080
aaaaaaaaa  aaaaaaaaa  1099



<210> 1035
<211> 302
<212> PRT
<213> Rattus norvegicus
<308> O70489
<400> 1035

Met Pro Gly Leu Trp Arg Gln Arg Leu Pro Ser Ala Trp Ala Leu Leu 
  1               5                  10                  15
Leu Leu Pro Phe Leu Pro Leu Leu Leu Pro Ala Ala Pro Ala Pro His 
             20                  25                  30
Arg Gly Ser Tyr Lys Pro Val Ile Val Val His Gly Leu Phe Asp Ser 
         35                  40                  45
Ser Tyr Ser Phe Arg His Leu Leu Asp Tyr Ile Asn Glu Thr His Pro 
     50                  55                  60
Gly Thr Val Val Thr Val Leu Asp Leu Phe Asp Gly Arg Glu Ser Leu 
 65                  70                  75                  80
Arg Pro Leu Trp Glu Gln Val Gln Gly Phe Arg Glu Ala Val Val Pro 
                 85                  90                  95
Ile Met Glu Lys Ala Pro Glu Gly Val His Leu Ile Cys Tyr Ser Gln 
             100                105                110
Gly Gly Leu Val Cys Arg Ala Leu Leu Ser Val Met Asp Glu His Asn 
         115                120                125
Val Asp Ser Phe Ile Ser Leu Ser Ser Pro Gln Met Gly Gln Tyr Gly 
     130                135                140
Asp Thr Asp Tyr Leu Lys Trp Leu Phe Pro Thr Ser Met Arg Ser Asn 
 145                150                155                160
Leu Tyr Arg Ile Cys Tyr Ser Pro Trp Gly Gln Glu Phe Ser Ile Cys 
                 165                170                175
Asn Tyr Trp His Asp Pro His His Asp Asp Leu Tyr Leu Asn Ala Ser 
             180                185                190
Ser Phe Leu Ala Leu Ile Asn Gly Glu Arg Asp His Pro Asn Ala Thr 
         195                200                205
Ala Trp Arg Lys Asn Phe Leu Arg Val Gly Arg Leu Val Leu Ile Gly 
     210                215                220
Gly Pro Asp Asp Gly Val Ile Thr Pro Trp Gln Ser Ser Phe Phe Gly 
 225                230                235                240
Phe Tyr Asp Ala Asn Glu Thr Val Leu Glu Met Glu Glu Gln Pro Val 
                 245                250                255
Tyr Leu Arg Asp Ser Phe Gly Leu Lys Thr Leu Leu Ala Arg Gly Ala 
             260                265                270
Ile Val Arg Cys Pro Met Ala Gly Val Ser His Thr Thr Trp His Ser 
         275                280                285
Asn Arg Thr Leu Tyr Asp Ala Cys Ile Glu Pro Trp Leu Ser 
     290                295                300



<210> 1036
<211> 2202
<212> DNA
<213> Homo sapiens
<308> NM_005155
<400> 1036

ggaagtggg  agaatcaag  cggggaaat  ggactttcg  gtcgctggg  gcaacgaag  60
ctggagagg  cttctttcc  ttcccagaa  atgtttgct  ctttttcct  tccccactg  120
cctaaatgg  tcgctccgc  tgtttcctc  ccagcacct  gggcgcaat  gaatattcc  180
ttgcccctc  tgtcctggg  ctgtgttgc  gggaacgct  gcgcggttg  cagagaaag  240
cccggacgt  acggatttg  gcgacccca  gcagcccgc  cttccccct  ccatccgtc  300
ttcccctgc  ttctctttc  tcacccttc  ccccgccac  gtgggttcc  gacttggga  360
aagtaaaca  cgggtggag  gaggcctac  gacccaggc  aggtgggag  ctgcactct  420
caaggggcc  gggctgctg  tcacgggta  taaagaact  cgcgttgtt  atggctgag  480
cgatgcatt  ggaagatcc  ggacctaga  aacaagtcc  ccgaacgct  agttggagg  540
gggacttcg  gtgcgcgtt  gcgggagca  gctggggct  tgggggcag  ggctccccg  600
ggcgtgggt  ctgcttctg  tgcctttcc  gccgctgct  ctgcttgca  cccccgcgc  660
ccaccgcgc  tcctacaag  cggtcatcg  ggtgcatgg  ctcttcgac  gctcgtaca  720
cttccgcca  ctgctggaa  acatcaatg  gacacaccc  gggactgtg  tgacagtgc  780
cgatctctt  gatgggaga  agagcttgc  acccctgtg  gaacaggtg  aagggttcc  840
agaggctgt  gtccccatc  tggcaaagg  ccctcaagg  gtgcatctc  tctgctact  900
gcagggggg  cttgtgtgc  gggctctgc  ttctgtcat  gatgatcac  acgtggatt  960
tttcatctc  ctctcctct  cacagatgg  acagtatgg  gacacggac  acttgaagt  1020
gctgttccc  acctccatg  ggtctaacc  ctatcggat  tgctatagc  cctggggcc  1080
ggaattctc  atctgcaac  actggcatg  tccccacca  gatgacttg  acctcaatg  1140
cagcagctt  ctggccctg  tcaatgggg  aagagacca  cccaatgcc  cagtatggc  1200
gaagaactt  ctgcgtgtg  gccacctgg  gctgattgg  ggccctgat  atggtgtta  1260
tactccctg  cagtccagc  tctttggtt  ctatgatgc  aatgagacc  tcctggaga  1320
ggaggagca  ctggtttat  tgcgggatt  ttttgggtt  aagactcta  tggcccggg  1380
ggccatagt  aggtgtcca  tggccggta  ctcccacac  gcctggcac  ccaaccgta  1440
cctttatga  acctgcatt  aaccttggc  ctcctgagg  tatattcag  ggtccccag  1500
aactcctcg  tccagagac  aagtggtgg  cttggaaag  agatgtcag  ctttggtgt  1560
cctgtgacc  cctcattgc  cccatatta  cccccattt  tagtagaga  ggggtttta  1620
tagagactt  gcctcccag  acccccttc  tctgctcct  catgaatga  aattccagg  1680
ctcccctac  tcatgtcct  tcatttggg  gattgctcc  tgctgtccc  ttctctcaa  1740
gccgaagtt  ggaagtgag  aaccatgtt  ttaacttgt  gctgctttt  ctgctgctg  1800
tcctccgta  ctggctgta  gggtggaga  cccaccccc  gcccaccac  ggggtctcc  1860
tccaggcca  tcaggacat  tttagcttc  ctcctcccc  tgttccctt  tttctctaa  1920
gtcccctga  atcagccct  ccaactcct  agagggact  cccatgaga  tggggttct  1980
aggctcccc  atggggaca  ttccgttct  gaagtgtca  tgttgggga  tatctgtgg  2040
ctatgaggc  catctcagg  ttggggatc  cccagtccc  atgatcagt  ttggagtac  2100
cccctggga  agcctagtt  ctttgaggc  ccaggccct  ttttaacta  ctttgaata  2160
gtgttatcc  tgtatttat  gaaataaag  tccatttcc  ca  2202



<210> 1037
<211> 302
<212> PRT
<213> Homo sapiens
<308> Q9UMR5
<400> 1037

Met Leu Gly Leu Trp Gly Gln Arg Leu Pro Ala Ala Trp Val Leu Leu 
  1               5                  10                  15
Leu Leu Pro Phe Leu Pro Leu Leu Leu Leu Ala Ala Pro Ala Pro His 
             20                  25                  30
Arg Ala Ser Tyr Lys Pro Val Ile Val Val His Gly Leu Phe Asp Ser 
         35                  40                  45
Ser Tyr Ser Phe Arg His Leu Leu Glu Tyr Ile Asn Glu Thr His Pro 
     50                  55                  60
Gly Thr Val Val Thr Val Leu Asp Leu Phe Asp Gly Arg Glu Ser Leu 
 65                  70                  75                  80
Arg Pro Leu Trp Glu Gln Val Gln Gly Phe Arg Glu Ala Val Val Pro 
                 85                  90                  95
Ile Met Ala Lys Ala Pro Gln Gly Val His Leu Ile Cys Tyr Ser Gln 
             100                105                110
Gly Gly Leu Val Cys Arg Ala Leu Leu Ser Val Met Asp Asp His Asn 
         115                120                125
Val Asp Ser Phe Ile Ser Leu Ser Ser Pro Gln Met Gly Gln Tyr Gly 
     130                135                140
Asp Thr Asp Tyr Leu Lys Trp Leu Phe Pro Thr Ser Met Arg Ser Asn 
 145                150                155                160
Leu Tyr Arg Ile Cys Tyr Ser Pro Trp Gly Gln Glu Phe Ser Ile Cys 
                 165                170                175
Asn Tyr Trp His Asp Pro His His Asp Asp Leu Tyr Leu Asn Ala Ser 
             180                185                190
Ser Phe Leu Ala Leu Ile Asn Gly Glu Arg Asp His Pro Asn Ala Thr 
         195                200                205
Val Trp Arg Lys Asn Phe Leu Arg Val Gly His Leu Val Leu Ile Gly 
     210                215                220
Gly Pro Asp Asp Gly Val Ile Thr Pro Trp Gln Ser Ser Phe Phe Gly 
 225                230                235                240
Phe Tyr Asp Ala Asn Glu Thr Val Leu Glu Met Glu Glu Gln Leu Val 
                 245                250                255
Tyr Leu Arg Asp Ser Phe Gly Leu Lys Thr Leu Leu Ala Arg Gly Ala 
             260                265                270
Ile Val Arg Cys Pro Met Ala Gly Ile Ser His Thr Ala Trp His Ser 
         275                280                285
Asn Arg Thr Leu Tyr Glu Thr Cys Ile Glu Pro Trp Leu Ser 
     290                295                300



<210> 1038
<211> 312
<212> DNA
<213> Rattus norvegicus
<308> AF068860
<400> 1038

gtctcacgt  ctctctgca  tctggaccc  gacttcacc  acatgaaaa  tcattactt  60
ctcctggtg  tgttatttt  tctcttctc  cagatggag  tgggtgctg  cattctcac  120
agtcttgga  gcagaacag  tcaataccg  tgcctccaa  atggaggat  ctgtctccg  180
tccagctgc  catctcata  caaactaca  ggaacatgt  aaccagata  gcccaactg  240
tgcaggagt  gacagtggt  tgaagaatg  acataaagg  caagcaagg  attgtaaaa  300
tagtgtttt  at  312



<210> 1039
<211> 69
<212> PRT
<213> Rattus norvegicus
<308> O89117
<400> 1039

Met Lys Thr His Tyr Phe Leu Leu Val Met Leu Phe Phe Leu Phe Ser 
  1               5                  10                  15
Gln Met Glu Leu Gly Ala Gly Ile Leu Thr Ser Leu Gly Arg Arg Thr 
             20                  25                  30
Asp Gln Tyr Arg Cys Leu Gln Asn Gly Gly Phe Cys Leu Arg Ser Ser 
         35                  40                  45
Cys Pro Ser His Thr Lys Leu Gln Gly Thr Cys Lys Pro Asp Lys Pro 
     50                  55                  60
Asn Cys Cys Arg Ser 
 65



<210> 1040
<211> 366
<212> DNA
<213> Homo sapiens
<308> NM_005218
<400> 1040

gtcagctca  cctccaaag  agccagcct  tccccagtt  ctgaaatcc  gagtgttgc  60
tgccagtcg  catgagaac  tcctacctt  tgctgttta  tctctgctt  cttttgtct  120
agatggcct  aggtggtaa  tttctcaca  gccttggcc  cagatctga  cattacaat  180
gcgtcagca  tggagggca  tgtctctat  ctgcctgcc  gatctttac  aaaattcaa  240
gcacctgtt  cagagggaa  gccaagtgc  gcaagtgag  tgggagtga  cagaagaaa  300
gacgcagaa  tgaaatgaa  tttttataa  cattctttt  ataaaggaa  attgctttt  360
aagtat  366



<210> 1041
<211> 68
<212> PRT
<213> Homo sapiens
<308> Q09753
<400> 1041

Met Arg Thr Ser Tyr Leu Leu Leu Phe Thr Leu Cys Leu Leu Leu Ser 
  1               5                  10                  15
Glu Met Ala Ser Gly Gly Asn Phe Leu Thr Gly Leu Gly His Arg Ser 
             20                  25                  30
Asp His Tyr Asn Cys Val Ser Ser Gly Gly Gln Cys Leu Tyr Ser Ala 
         35                  40                  45
Cys Pro Ile Phe Thr Lys Ile Gln Gly Thr Cys Tyr Arg Gly Lys Ala 
     50                  55                  60
Lys Cys Cys Lys 
 65



<210> 1042
<211> 6207
<212> DNA
<213> Rattus norvegicus
<308> AF069525
<400> 1042

cacgagcgg  tcccgggtt  aggagacgc  gacccgggc  cagagccga  ttcctggaa  60
gaggagcgc  cgggacccc  ccgtatggc  agctccggc  cttcgtccc  agtgggcgc  120
gggagcccc  atcttgagc  gggtgactt  ggatcctgt  attcacgaa  ctctcaaaa  180
tcggatgcc  atgcaagtt  cttgagagc  gctcgggcg  ggcacctgg  aaaggccct  240
gactacatc  aaaatggag  ggacgtcaa  atctgtaac  agaatgggt  gaatgcgct  300
catcttgct  ccaaagaag  gcatgtgga  gtggtctcc  agctgctgc  gagagaagc  360
aacgtcgat  agccaacaa  gaaaggaaa  acagcctta  acatcgcat  cttggctgg  420
caagcggaa  tggtcaagg  cttggttac  aacggagcg  acgtcaacg  acagtctca  480
aatggcttc  cgccgctgt  tatggcggc  caggagaac  acctggaag  cgtcaggtt  540
cttctggac  atggtgcca  ccaaagcct  gctacagag  atggcttca  gccattggc  600
gtggctctt  aacaaggtc  cgaccaagt  gtatccctc  tgctcgaga  cgacacgaa  660
ggaaaagtg  gcctcccag  cctccacat  gcggcccgg  aagatgaca  caaagcggc  720
gctctgctc  tacagaacg  caccaatgc  gacatagag  caaagagtg  cttcacccc  780
ctccacata  ctgcccact  cgggaatat  aatgtggcc  cgttgctgt  aaaccgagc  840
gctgccgtg  acttcaccg  acggaatga  atcactcct  tgcatgttg  ctcgaaacg  900
ggaaacgca  atatggtaa  gctgttgct  gaccggggt  cgaagatcg  cgccaagac  960
agggacggt  tgaccccgc  gcactgcgg  gcgagaagt  gccacgaac  ggtggtaga  1020
atgttgctg  acagagccg  ccccatcct  tcgaaaacc  agaatggac  gtccccact  1080
cacatggcc  cacaaggag  ccatttaaa  tgcgtccaa  tcctcctcc  gcacaacgt  1140
cccgtggat  acgtcacca  cgactacct  accgccctc  acgtggcgg  ccactgcgg  1200
cattacaaa  ttgccaagg  tcttttgga  aagaaagct  accccaatg  caaagctct  1260
aatggcttc  cccccctcc  tatcgcctg  aaaaagaac  gaatccgag  aatggaact  1320
cttttgaag  acggtgcat  tattcaagc  gtaaccgag  cgggcctta  cccaatcca  1380
gtcgctgcc  tcatgggac  tgtaaatat  gtgtcacag  taatgcatc  tggagcctc  1440
ccaaacacc  ccaacgtga  aggagaaac  gcattgcat  tggcggctc  gtcggggca  1500
gcagaagtg  tgcggtatt  ggtacaaga  ggagctcag  tagaagcaa  agctaagga  1560
gagcaacac  ccactccac  tttcagccg  ctcgggaag  ctgagatag  gcaacaagt  1620
ttacagcaa  gagcgtccc  gaatgcagc  acaacttcc  ggtacaccc  ccttcacct  1680
tcggccaga  aggggcatg  ggatgtagc  gccttcctt  tggaccatg  agcattctt  1740
tccataaca  caaagaagg  attcacgcc  ctgcatgtg  ctgcaaagt  tgggaagct  1800
gaagtggca  gtctcctgc  gcagaagag  gcgtctcct  atgccgctg  gaagagcgg  1860
ctaactcca  tgcatgtag  agcacatta  gataatcag  aagtggccc  tctgctttt  1920
gaccaggga  cctcacccc  cgcagctgc  aagaacggt  atacgccac  gcacatcgc  1980
gccaagaag  accagatgg  catagccac  tccctgctg  agtacggtg  tgatgcaaa  2040
gccgttacc  ggcaaggga  tgcgtccgt  caccttgca  cgcaggaag  gcacgtgga  2100
atggtgtcg  tgctcctca  tagaaatgc  aacgtcaac  tgagcaata  gaggggcct  2160
aacccactc  acctggggg  tcaagaaga  cgagtgaac  tggctgagg  ccttgtcaa  2220
caaggggcc  acgtggatg  acagacaaa  atgggctac  cgccgctcc  tgtgggctg  2280
cactatgga  acatcaaaa  agtcaattt  ctgctgcag  attctgcga  agttaatgc  2340
aagacaaag  atggataca  gccactgca  caggcagcc  agcaggggc  cacacacat  2400
atcaacgtc  tgctccaga  caacgcttc  cccaatgaa  tcactgtga  tgggaacac  2460
gccctggcc  tcgcccgac  ccttggcta  atctcggtg  ttgacaccc  aaaggtcgt  2520
acagaggaa  ttatgacca  cactaccat  acggagaag  acaaaatga  tgtcccaga  2580
acaatgaat  aagtcctcg  catgtcaga  gatgaagtt  gtaaaggca  cgcccccga  2640
aagctcagt  atggggaat  tatctcaga  ggtgaagaa  gtgaagatg  catcacagg  2700
gacactgac  aatctctcg  cccacagga  ctcaaggag  tgggcgatg  ctccctgcc  2760
gccgagggc  atgtgggct  cagtctcgg  gcccgttct  gcagtcttc  ctccttcag  2820
tcggatagg  cctacaccc  gaacagaag  tcctatgcg  gggacagca  gatgatcga  2880
gagcttctg  tgccatcca  agagcagca  ctcccattc  cgagggagt  tgactccga  2940
tccctcaga  actacagtt  gccagcaga  acactggac  atgtgaacc  ggtctccag  3000
cctgtgcat  ctgggtttc  ggttagctt  atggtggac  cgagagggg  ctccatgcg  3060
ggaagccgc  accacggga  gcggatcat  atccctccc  gcaagtgta  ggcccccac  3120
cgcatcact  gccgcctgg  aaagagaca  aaactggcc  acccacccc  ccatggtgg  3180
aggagaggg  ttagcagta  gctggtaga  atgggtcct  cgggggcac  atttttagg  3240
ccggtcata  tggaaatcc  tcattttgg  tccatgaga  gaaaggaga  ggaactcat  3300
gtcctccgg  gcgagaacg  agagacctg  aaggaacac  agtttgaca  caaaaacga  3360
gacctctcg  agctcctca  tggcatgga  gaagaactt  acagcccag  agagttggg  3420
acaaagcgc  tctgcagaa  catcacgaa  gatttcccc  agtatttcg  tgtggtttc  3480
cggattaag  aggaaagca  ccagattgg  cccgaaggt  ggattctga  cagcaccac  3540
gtccccctc  tccaggcgt  tttcccaga  ggtgcctta  ccaaaagga  ccgtgtggg  3600
ctgcaggct  agcccgtac  agaggagac  gtgaaaaag  tccttggaa  caaagcaac  3660
tttagccca  ttgtcacgg  ggagccgag  aggaggaaa  ataagccga  caccatgac  3720
atcccgatc  ccatgacca  cccggtgcc  ccaccctcg  gagaagggg  gtccaatgg  3780
tacaaaggg  gaaacacgc  cagcctgcg  ttcctctgc  ggattacag  agggacttc  3840
ccggctcag  gggaagaca  cacaggcac  acccctctg  ccttcataa  ggactgtgt  3900
tctttcaca  ccaatgttt  agccaggtt  tggctggcg  actgccatc  ggtgttaga  3960
accgtaggc  tagcctcgc  gctgtacag  gagttgata  gtgtccctt  catggccaa  4020
tttgttgtt  ttgccaaaa  aaacgaccc  gtggaagcc  ccctaaggt  cttctgtat  4080
acagacgac  gagtggaca  aaccctgga  cagcaggag  atttcgagg  ggttgccag  4140
agcaaagac  tcgaggttc  ggaaggaaa  cccatctat  ttgattgct  tggaaacct  4200
gctcctctg  ccaaaggag  gcagcagct  gtttttaac  tctattctt  caaagaaaa  4260
agactgcca  tttccatca  ggttagaga  accagccaa  agccctgcg  cgtctgtct  4320
ttcctgaag  agccgaaaa  aacaaaagg  ttaccccaa  cggctgttt  caacttaaa  4380
attactcta  cggcgcata  aaaggctga  aaggcagac  gacgccaga  cttcacatc  4440
ctagcctta  gtaagcgct  cagctactt  actgagccc  gcatgagtc  gcagagtcc  4500
tgtgagcgg  cggatatca  gatggcaat  gtagccgat  acctgggac  tagttggac  4560
gagctggca  gggaactga  tttttcagt  gatgaaatc  accaaatac  agtggaaaa  4620
cccaattct  taatttctc  gagcttcat  ttattaaaa  agtgggtga  gagagacgg  4680
aagaatgcc  caactgatg  cttaacttc  gtcttaaca  aaattaacc  aatagacat  4740
gtaactctg  tggaaggac  aatatttga  tatgggaat  tttcaggca  cagaagctt  4800
gcagatgaa  acaatgttt  ccatgaccc  gttgatggt  ggcagaacg  gacgccaag  4860
ggaagccta  agtccccgg  gcaagcgcg  agaatcacc  gtgggttac  ggaccgtct  4920
gacgacagg  ctgaccagg  tcgggatcc  attacctca  acctcacag  agaagctgg  4980
aagttcgaa  caaacggaa  ccacgcaga  gtcattcca  aagcaaagg  caaggccta  5040
tttcctgaa  cccaaaacg  tatagggaa  cagagcatc  aggagaact  gaaaccaaa  5100
acacacgga  gtggtcgcg  tgaggaacc  gtgtcaccc  tcacaggct  ccagaaatc  5160
ctggaagaa  ccagcaagc  tgtcataga  gacgcacct  aaccctgtg  gcctgtcgg  5220
atgaaaaag  tgaccagga  tccggctga  ggcaaagcc  ggctcaacc  ccaggaaga  5280
gaggggtcc  ccaggtcag  gcctaagca  ggagaaggc  ataaggtga  aacaaagaa  5340
gaaatccgg  atgtggaga  gaaagccca  tagtgacgg  gacgtcagt  caggaccac  5400
cgttcgtac  gccagtatt  agaaactca  cagagatca  cagggagga  aatctctag  5460
aagagcgga  tgtggatct  ccaccccac  catcagtga  atgtttggg  ttttgggtt  5520
ttttggttt  tttttttaa  gcagaagga  aaagaaaat  acctttttt  tatttagca  5580
gagccaatt  acagagcat  gagactcac  ttcattccc  gcgctgaca  gcgtgcact  5640
agcaagtgc  atgtaagat  caagaagcc  tgttgttca  actcagcct  aagtaattt  5700
gtgtcactt  cggagaagg  cagacaacc  acgacacct  tgccaccgg  aggaggggg  5760
ccagcacca  gtggagcgg  cccaatcca  gaagacacc  ttgaaatta  taaaaccca  5820
cacaagctc  ccttatttt  cttggaccc  aactaactg  cagggtata  acactgttt  5880
tttcttttt  ttttttaaa  gtttaaata  taataagag  aatcaatag  tttgctgta  5940
ataataaca  tgtaaattc  aacagaaga  actacaata  agaattata  ggcacctgc  6000
tcacggaac  caaagatac  acaaacgcg  ccaatgaca  gcgtaccaa  tggcctcac  6060
ctggacaag  acgggaatc  ggcgcgtgc  ggacgctct  tcactgact  ctgtatatt  6120
gcaattatg  tgtttgtac  cgccaaact  ctggcttgg  tttaaaaag  aaatgcaaa  6180
ctttaaaaa  aaaaaaaaa  aaaaaaa  6207



<210> 1043
<211> 751
<212> PRT
<213> Rattus norvegicus
<308> P97570
<400> 1043

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
  1               5                  10                  15
Leu Phe Ser Asn Pro Phe Arg Ala Lys Glu Val Ser Leu Ala Asp Tyr 
             20                  25                  30
Ala Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
         35                  40                  45
Asn Ala Ser Asn Arg Thr Trp Asp Cys Asp Leu Val Ser Pro Arg Asn 
     50                  55                  60
Pro Gln Ser Asp Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Val 
 65                  70                  75                  80
Leu Val Asn Phe Gln Gln Tyr Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                 85                  90                  95
Ser Ser Glu Gln Val Leu His Val Glu Val Leu Gln Leu Thr Asp Leu 
             100                105                110
Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu Leu 
         115                120                125
Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Thr Cys Ala Asn 
     130                135                140
Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys Arg 
 145                150                155                160
Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His Ala 
                 165                170                175
Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr Ala 
             180                185                190
Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn Ala 
         195                200                205
Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu His 
     210                215                220
Leu Ala Cys Gln Met Gly Lys Gln Glu Met Val Arg Val Leu Leu Leu 
 225                230                235                240
Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile His 
                 245                250                255
Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile Ser 
             260                265                270
Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala Ser 
         275                280                285
Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu Lys 
     290                295                300
Arg Gly Cys Asp Val Asp Ser Thr Ser Ala Ser Gly Asn Thr Ala Leu 
 305                310                315                320
His Val Ala Val Thr Arg Asn Arg Phe Asp Cys Val Met Val Leu Leu 
                 325                330                335
Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr Pro 
             340                345                350
Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala Leu 
         355                360                365
Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu Thr 
     370                375                380
Pro Ala Phe Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu Met 
 385                390                395                400
Pro Val Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met Arg 
                 405                410                415
Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly Gly 
             420                425                430
Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys Ala 
         435                440                445
Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr Ser 
     450                455                460
Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met Ala 
 465                470                475                480
Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg Gly 
                 485                490                495
Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg Glu 
             500                505                510
Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val Met 
         515                520                525
Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu Phe 
     530                535                540
Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Thr Pro 
 545                550                555                560
Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val Trp 
                 565                570                575
Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro Asn 
             580                585                590
Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu Asp 
         595                600                605
Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys Gly 
     610                615                620
Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly Thr 
 625                630                635                640
Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg Pro 
                 645                650                655
Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu Leu 
             660                665                670
Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala Val 
         675                680                685
Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe Arg 
     690                695                700
Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser Asp 
 705                710                715                720
Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr Glu 
                 725                730                735
Tyr Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
             740                745                750



<210> 1044
<211> 3470
<212> DNA
<213> Homo sapiens
<308> AL136710
<400> 1044

agctttaaa  ggatgtctg  gaagtggtc  aaaggatct  aacctcaat  aagtggggt  60
ttttaaaaa  attttttgg  gggcctgaa  ttttgaaaa  cttcgaact  tgagtgggg  120
aagatgtat  attcctcaa  tgcctacga  gatatcaag  tgctgagag  aattcagcg  180
tggtgaaga  agtggatac  aaccaggga  tggtttcct  gagctgttt  ggaggttga  240
tctaaatca  tgcttaagg  attcctgga  acatcagga  aacatttga  catccaagc  300
tagtggaaa  ggctttacc  cagagtgaa  atgcaatga  cggggacac  gacaaatat  360
ttgggccac  ggaccttaa  gaattgggt  atgattccc  gcctgcaga  ggttacatg  420
gctttagtc  cggagcgcg  tctgccagc  tccgctcct  cagttcgga  gggtcttac  480
ccttgaaca  aagctccta  gcacgggac  gcatgatga  tgaagaact  ctcgtgcca  540
ccaaagagc  gcatctaac  ttcacaagg  aatttgatt  agattctct  agacattac  600
gctgggctg  agacacctt  gacaatgtc  atcttgttc  aagccccat  cattctggg  660
ttctggtta  ctttatggt  gacgcgaga  ggggctcca  gagaggaag  cgtcatcac  720
ggatgagaa  catcattcc  ccacgcaag  gtacggccc  cactcgaat  acctgccgt  780
tggtaaaga  acataaact  gccaaccca  cccccatgg  ggaaggaga  ggattagcc  840
gtaggctgg  agaaatggg  cctgcaggg  cacaatttt  aggccctgt  atagtggaa  900
tccctcact  tgggtccat  agaggaaaa  agagagaac  cattgttct  cgaagtgaa  960
atggtgaaa  ttggaagga  catcagttt  acagcaaaa  tgaagattt  accgagtta  1020
ttaatggca  ggatgaaga  cttgatagc  cagaagagt  agggaaaaa  cgtatctgc  1080
ggattatca  gaaagattt  ccccagtat  ttgcagtgg  ttcccggat  aagcaggaa  1140
gcaaccaga  tggtcctga  ggtggaatt  tgagcagca  cacagtgcc  cttgttcaa  1200
catctttcc  agagggtgc  ctaactaaa  gaattcgag  gggcctcca  gcccagcct  1260
ttccagatg  aattgtgaa  aagatcctt  gaaacaaag  aacttttag  ccaattgtc  1320
ctgtggaac  aagaagacg  aaattccat  aaccaatca  aatgaccat  ccggtgccc  1380
cgccctcag  agaaggtgt  tccaatgga  acaaagggg  cactacacc  aatctgcgt  1440
ttctctgta  cattacagg  ggcacttcg  ctgctcagt  ggaagacat  acaggaaca  1500
ctcctttga  gtttataaa  gattgtgtc  cctttacaa  caatgtttc  gccagattt  1560
ggcttgcag  ctgccatca  gttttagaa  ctgtggggt  agccacgca  ctgtacaga  1620
aattgatat  tgttccata  atggccaag  ttgttgttt  tgccaaaat  aatgatccc  1680
tagaatctt  cttgcgatg  ttctgcatg  cagatgaca  agtggacaa  actttagag  1740
aacaagaga  ttttgagga  gtcgcaaga  gcaaagata  tgaggttct  gaaggaaaa  1800
ctatttatg  tgattgtta  ggaaatttg  ccccactta  caaaggagg  cagcaactt  1860
tttttaact  ttattcttt  aaagaaaat  gactgccat  ttccatcaa  attagagac  1920
ccagccaag  gccctgtgg  cgtctgtct  ttctgaaag  accaaagac  acaaaagga  1980
tgcctcaaa  agcggtttg  aacttaaat  tcactctgc  agcacataa  aagattgag  2040
aaacagatg  acgacagag  ttcgcatcc  tagctttac  taagcgcta  agctacttg  2100
ctgagcctg  aatgagtcc  cagagtcca  gtgaacgga  agatatcag  atggcaata  2160
tagccgatc  cctgggact  agttggaca  aactggcaa  ggaactgaa  ttttcagtg  2220
atgaaatca  tcaaatacg  gtggaaaat  caaattctt  aatttctca  agcttcatg  2280
ttttaaaaa  atgggttac  agagacgga  aaaatgcca  aactgatgc  ttaacttcg  2340
tcttgacaa  aattaatcg  atagatata  tgacactgc  agaaggacc  atatttgat  2400
atggaaata  ttcaggcac  agaagtttt  cagatgaga  caatgtttt  catgaccct  2460
ttgatggtt  tccttccct  caagtggaa  tggaaaccc  cacagggtt  cactacaca  2520
cacctaccc  tttccagca  gatgattat  ttagtgata  ctctagcat  gaatctccc  2580
ttagaaccc  tagtagact  agtgatggg  tagtgcctt  ccaggggaa  atagagcat  2640
ccgcagatg  acctccagt  gtaactgca  aagacgctt  cttagaaga  agcaaactg  2700
aagactcag  gcctttaac  gaaatgcct  aagcagtga  gtagatgag  gccagttgg  2760
gaatgtatg  ctgagttgg  agaatgaga  atcaagtgg  aacctagag  cctgcgctc  2820
agctcgaag  gtaactggt  ggttactag  tcgactgga  gacagccct  accagtgta  2880
agattccat  acctcatat  tcaaaggag  agctggcaa  tttgaagca  atggaagcc  2940
tacagaaat  actccagaa  caaagacaa  atcttactt  ccagaatcc  aaaatgatg  3000
aggaaaaca  agtaccaag  aaactctga  accaaaaat  catggatct  gtcatgttg  3060
agaaccagc  tcaccacta  cagcatatc  gaaatctct  gaagaaacc  gcaagctta  3120
aatagaaga  actaaaccc  gtgtgcctg  cagtatgaa  aagatgagt  ggacttctc  3180
agcagatgg  aagccaagg  ttagcctcc  tgaagaaga  gggtccagt  ggtctgagc  3240
aaagcaggg  gaaggtttt  aggtgaaaa  gaagaaaga  atccggcat  tggaaaaga  3300
gagccactc  taacagcga  cggtcagtc  aggatcata  gtttttact  ccagtattg  3360
gaaattcgt  gaagaaatg  cagcaggaa  taaaaattc  ccgagaagt  tgtgtgtgt  3420
cgctgcttc  acacattaa  ggcatgatt  tttttatgc  aaaaaaaaaa  3470



<210> 1045
<211> 812
<212> PRT
<213> Homo sapiens
<308> AL136710
<400> 1045

Met Ala Leu Pro Gln Ser Glu Asp Ala Met Thr Gly Asp Thr Asp Lys 
  1               5                  10                  15
Tyr Leu Gly Pro Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro 
             20                  25                  30
Ala Glu Gly Tyr Met Gly Phe Ser Leu Gly Ala Arg Ser Ala Ser Leu 
         35                  40                  45
Arg Ser Phe Ser Ser Asp Gly Ser Tyr Thr Leu Asn Arg Ser Ser Tyr 
     50                  55                  60
Ala Arg Asp Ser Met Met Ile Glu Glu Leu Leu Val Pro Ser Lys Glu 
 65                  70                  75                  80
Gln His Leu Thr Phe Thr Arg Glu Phe Asp Ser Asp Ser Leu Arg His 
                 85                  90                  95
Tyr Ser Trp Ala Ala Asp Thr Leu Asp Asn Val Asn Leu Val Pro Ser 
             100                105                110
Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly 
         115                120                125
Gly Ser Met Arg Gly Ser Arg His His Gly Met Arg Ile Ile Ile Pro 
     130                135                140
Pro Arg Lys Cys Thr Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys 
 145                150                155                160
Arg His Lys Leu Ala Asn Pro Pro Pro Met Val Glu Gly Glu Gly Leu 
                 165                170                175
Ala Ser Arg Leu Val Glu Met Gly Pro Ala Gly Ala Gln Phe Leu Gly 
             180                185                190
Pro Val Ile Val Glu Ile Pro His Phe Gly Ser Met Arg Gly Lys Glu 
         195                200                205
Arg Glu Leu Ile Val Leu Arg Ser Glu Asn Gly Glu Thr Trp Lys Glu 
     210                215                220
His Gln Phe Asp Ser Lys Asn Glu Asp Leu Thr Glu Leu Leu Asn Gly 
 225                230                235                240
Met Asp Glu Glu Leu Asp Ser Pro Glu Glu Leu Gly Lys Lys Arg Ile 
                 245                250                255
Cys Arg Ile Ile Thr Lys Asp Phe Pro Gln Tyr Phe Ala Val Val Ser 
             260                265                270
Arg Ile Lys Gln Glu Ser Asn Gln Ile Gly Pro Glu Gly Gly Ile Leu 
         275                280                285
Ser Ser Thr Thr Val Pro Leu Val Gln Ala Ser Phe Pro Glu Gly Ala 
     290                295                300
Leu Thr Lys Arg Ile Arg Val Gly Leu Gln Ala Gln Pro Val Pro Asp 
 305                310                315                320
Glu Ile Val Lys Lys Ile Leu Gly Asn Lys Ala Thr Phe Ser Pro Ile 
                 325                330                335
Val Thr Val Glu Pro Arg Arg Arg Lys Phe His Lys Pro Ile Thr Met 
             340                345                350
Thr Ile Pro Val Pro Pro Pro Ser Gly Glu Gly Val Ser Asn Gly Tyr 
         355                360                365
Lys Gly Asp Thr Thr Pro Asn Leu Arg Leu Leu Cys Ser Ile Thr Gly 
     370                375                380
Gly Thr Ser Pro Ala Gln Trp Glu Asp Ile Thr Gly Thr Thr Pro Leu 
 385                390                395                400
Thr Phe Ile Lys Asp Cys Val Ser Phe Thr Thr Asn Val Ser Ala Arg 
                 405                410                415
Phe Trp Leu Ala Asp Cys His Gln Val Leu Glu Thr Val Gly Leu Ala 
             420                425                430
Thr Gln Leu Tyr Arg Glu Leu Ile Cys Val Pro Tyr Met Ala Lys Phe 
         435                440                445
Val Val Phe Ala Lys Met Asn Asp Pro Val Glu Ser Ser Leu Arg Cys 
     450                455                460
Phe Cys Met Thr Asp Asp Lys Val Asp Lys Thr Leu Glu Gln Gln Glu 
 465                470                475                480
Asn Phe Glu Glu Val Ala Arg Ser Lys Asp Ile Glu Val Leu Glu Gly 
                 485                490                495
Lys Pro Ile Tyr Val Asp Cys Tyr Gly Asn Leu Ala Pro Leu Thr Lys 
             500                505                510
Gly Gly Gln Gln Leu Val Phe Asn Phe Tyr Ser Phe Lys Glu Asn Arg 
         515                520                525
Leu Pro Phe Ser Ile Lys Ile Arg Asp Thr Ser Gln Glu Pro Cys Gly 
     530                535                540
Arg Leu Ser Phe Leu Lys Glu Pro Lys Thr Thr Lys Gly Leu Pro Gln 
 545                550                555                560
Thr Ala Val Cys Asn Leu Asn Ile Thr Leu Pro Ala His Lys Lys Ile 
                 565                570                575
Glu Lys Thr Asp Gly Arg Gln Ser Phe Ala Ser Leu Ala Leu Arg Lys 
             580                585                590
Arg Tyr Ser Tyr Leu Thr Glu Pro Gly Met Ser Pro Gln Ser Pro Cys 
         595                600                605
Glu Arg Thr Asp Ile Arg Met Ala Ile Val Ala Asp His Leu Gly Leu 
     610                615                620
Ser Trp Thr Glu Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile 
 625                630                635                640
Asn Gln Ile Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe 
                 645                650                655
Met Phe Leu Lys Lys Trp Val Thr Arg Asp Gly Lys Asn Ala Thr Thr 
             660                665                670
Asp Ala Leu Thr Ser Val Leu Thr Lys Ile Asn Arg Ile Asp Ile Val 
         675                680                685
Thr Leu Leu Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Thr 
     690                695                700
Arg Ser Phe Ala Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Gly 
 705                710                715                720
Tyr Pro Ser Leu Gln Val Glu Leu Glu Thr Pro Thr Gly Leu His Tyr 
                 725                730                735
Thr Pro Pro Thr Pro Phe Gln Gln Asp Asp Tyr Phe Ser Asp Ile Ser 
             740                745                750
Ser Ile Glu Ser Pro Leu Arg Thr Pro Ser Arg Leu Ser Asp Gly Leu 
         755                760                765
Val Pro Ser Gln Gly Asn Ile Glu His Ser Ala Asp Gly Pro Pro Val 
     770                775                780
Val Thr Ala Glu Asp Ala Ser Leu Glu Asp Ser Lys Leu Glu Asp Ser 
 785                790                795                800
Val Pro Leu Thr Glu Met Pro Glu Ala Val Met Ter 
                 805                810



<210> 1046
<211> 432
<212> DNA
<213> Rattus norvegicus
<308> AF069775
<400> 1046

tattatcgc  gcacagcca  caatttgtt  gggaaagcc  gtcacgatt  tcacgtcat  60
gtagaagag  ctccccgct  gaaaaagaa  cctcagagt  ccgtgtaca  cacagggag  120
aacggtatc  tgttgtgtg  agcagaagg  gaaccccag  ccacaatca  atggagagt  180
aatggcttg  cgattgaaa  tcatccatt  cctggtgac  ttatgttcc  cagggaaat  240
agttttaca  acttacagc  aaatcatac  gctgtatat  agtgcgaag  ctcaaatat  300
catggaacc  ttttggcca  cgccaatat  gatgttgta  atgttgttc  actgataca  360
actaagaat  aagaaaact  tgaaactgt  gttgggtac  gcgctttct  acattgcga  420
ttctttgct  ca  432



<210> 1047
<211> 144
<212> PRT
<213> Rattus norvegicus
<308> AAC21580
<400> 1047

Tyr Tyr Arg Cys Thr Ala Ser Asn Leu Leu Gly Lys Ala Ser His Asp 
  1               5                  10                  15
Phe His Val Ile Val Glu Glu Pro Pro Arg Trp Lys Lys Lys Pro Gln 
             20                  25                  30
Ser Ala Val Tyr Ser Thr Gly Ser Asn Gly Ile Leu Leu Cys Glu Ala 
         35                  40                  45
Glu Gly Glu Pro Gln Pro Thr Ile Lys Trp Arg Val Asn Gly Leu Pro 
     50                  55                  60
Ile Glu Asn His Pro Phe Pro Gly Asp Val Met Phe Pro Arg Glu Ile 
 65                  70                  75                  80
Ser Phe Thr Asn Leu Gln Pro Asn His Thr Ala Val Tyr Gln Cys Glu 
                 85                  90                  95
Ala Ser Asn Ile His Gly Thr Ile Leu Ala Asn Ala Asn Ile Asp Val 
             100                105                110
Val Asp Val Val Pro Leu Ile Gln Thr Lys Asn Glu Glu Asn Tyr Glu 
         115                120                125
Thr Val Val Gly Tyr Ser Ala Phe Leu His Cys Glu Phe Phe Ala Ser 
     130                135                140



<210> 1048
<211> 7642
<212> DNA
<213> Homo sapiens
<308> AF002246
<400> 1048

cggaccctg  gcgcccccg  cccggctcc  ggccggctc  ggggagaag  cgcccgagg  60
gaggcgccg  acagatcgc  tttcggagg  ggcgcaggt  ctgtaaact  caaaccata  120
tcctgtctt  atactgcaa  caaatcata  tggaactaa  gggaactta  tttactgtt  180
ccaggttaa  taaggtctc  gctgtaaac  aaaagtgag  ggagacatt  agattttca  240
tcttaccgg  ttgtcttct  cctgaagag  aatggagcc  cttttactt  gaagaggac  300
aatcgtata  ctaatgttc  tcctgttaa  attctcaaa  gcaattgaa  taccatctt  360
agttcaaca  gttccaaca  tcataaaac  gtcaaaagt  caagttgcc  ttcccttcg  420
tgagtattt  caaattgaa  gtgaagcta  aggaaatcc  gaaccaaca  tttcgtgga  480
taaggatgg  aaccctttt  atttcactg  ccatcggat  attccatcg  acaattcag  540
aacattcag  atcccaaac  aggggcaca  atctcactt  caagggaaa  accgctgct  600
tgcttcaaa  aaactggga  tcgctatgt  agaagaaat  gaatttata  ttccaagtg  660
tccaaaatt  ccaaaagaa  aaattgacc  tcttgaagt  gaggaggga  atccaattg  720
cctcccatg  aatcctccc  aaggcctcc  acctttaca  atttattgg  tgaatattg  780
attagaaca  atcgaacaa  atgaaagag  atacatgag  caaaaggga  atctatact  840
cgcaaacgt  gaagaaaag  acagtcgca  tgactactg  tgctttgct  catttccaa  900
attaaggac  attgtacag  aaatgccaa  gaaactaac  gttaacagt  taaagcatg  960
taatgactc  agttcatcc  cagaaattg  ttccaaggc  aattccatc  agcaaagaa  1020
acccaaact  ctgttgcct  ccactgaga  tggcagtga  tcttcaatt  ccatcctca  1080
aggggaaat  ttgctgctt  agtgttttg  tgaaggctt  ccaactcca  aggttgatt  1140
gaacaaaat  ggtggtgac  taccaaagg  gagagaagc  aaagaaaat  atggcaaga  1200
tttgaagat  gagaatgtc  cctaccagg  caaaggaaa  tatcgctgc  cagccagca  1260
tttcttggg  acagccact  acgattttc  cgttatagt  gaagagcct  ctcgctgga  1320
aaagaagcc  cagagtgct  tgtatagca  cggaagcaa  ggcatcttg  tatgtgagg  1380
tgaaggaga  cctcaaccc  caatcaagt  gagagtcaa  ggctcccca  ttgacaatc  1440
tccatttgc  ggtgatgtt  tcttcccca  ggaaatcag  tttaccaac  ttcaaccaa  1500
tcatactgc  gtgtaccag  gtgaagcct  aaatgtcca  ggaactatc  ttgccaatg  1560
caatattga  gttgtggat  tccgtccat  gatacaaac  aaagatgga  aaaattacg  1620
tacagtggt  gggtacagt  ctttcttac  ttgcgagtt  tttgcttca  ctgaggcag  1680
cgtgtcctg  cagaaggtg  aagaagtga  acccctgga  ggcaggcgg  atcatatct  1740
tgaaaatgg  acattgcag  tcaacagaa  caccgaaga  gatgctggg  cttactcat  1800
ttgggtaga  aatgctata  gaaaaactg  agtcacagc  aatttggat  ttagaaatg  1860
tacaaaact  agagtttct  ctaagaatc  tcgtatccc  aaattgcat  tgcttgaat  1920
acattgtga  agcaaatgt  actcacatt  gaaacacag  ttgaagttg  cctggagta  1980
agatggaga  gcctttgaa  ttaatggca  agaagatgg  aggataatt  ttgatggag  2040
taatttgac  atatctaat  taactttag  ggaccaagg  atttactgc  gttcagctc  2100
tactgctct  gacagtgct  ccgatataa  tcaagtaac  gttcttgat  ttccggatc  2160
accagaaaa  cttcacttg  ctgaaagac  gaacaggag  gttcggctg  cctgggaag  2220
tggagctga  cacaacagc  atattagcg  gtatattgt  gaatttgaa  gaaacaaag  2280
agagcctgg  aggtgggag  aactgacca  agtccaagg  aagaaaacc  cagttatct  2340
acctttggc  ccatttgtg  gataccagt  cagggtcat  gccgtgaac  aagtaggga  2400
aagtcagcc  agccagccg  cagaccatc  tgaaacacc  ccagcagct  cagatagga  2460
tccacaaaa  ataagggtt  aagcctctc  acccaagga  atgattata  agtgggagc  2520
tttgaaatc  atggagcag  atggaccag  cctagagta  agagtgacc  ggaagccac  2580
gggagcccc  gtggagtgg  aagaagaaa  agtcacaaa  cacacattg  gggtgatga  2640
gcctgctgt  tatgcccct  atgatgtca  ggtccaggc  atcaatcaa  taggatctg  2700
gcctgaccc  cagtcagtg  ctctctatt  tggagaaga  tatcctgat  cagctccag  2760
gatccatgg  gtggacgtt  taaacagta  attagttaa  gttacctgg  caacagttc  2820
aaaggacag  gtacatgga  gtctgaaag  ctatcagat  aattggtgg  aaacaaaaa  2880
tctgttgga  ggaagaaca  atcccaaag  agtgaacat  ctaagattt  caggacaaa  2940
aaactctgg  atggttcct  ccttagatg  ctttagtga  tttcattta  cagtcttag  3000
ctataactc  aaaggagct  gtcctgaaa  tgagcctta  atatttcaa  caccagaag  3060
agtacctga  cagccaact  ttctaaagg  catcaaagt  gataaagac  ctgccactt  3120
atcttgggg  ctacctaag  aattaaatg  aaacttaac  ggctatctt  tgcaatatc  3180
gataataaa  gacacctac  agattggag  attaaatga  attaacatt  caactccat  3240
aaagcccag  tggcacctc  caaacctga  tgcaactac  aagtacaaa  tctacttga  3300
ggcttgcac  tcacagggc  gtggaaaac  gatcacgga  gaaagctcc  ccttaggag  3360
agggagtaa  ggtatcggg  agatatcag  agtaaatct  actcaaaag  ctcacccag  3420
agaggtatt  gagccggga  ctgaacata  agttcgcct  atgactaag  attggggcg  3480
taacgatag  atttttcaa  atgtaattg  gacaagagg  agagaatat  ctggtttat  3540
tgatgacat  tccactcaa  gctggttta  tggactgat  tgtgcgatt  ctcttctca  3600
actactatt  ttaactgtt  gctttgtga  gaggaatag  ggtggaaag  actcagtta  3660
agaaaagga  gatttgcat  cagacccag  aattcagtc  gtaaaagat  aaacctttg  3720
tgaatacag  gacagtgat  aaaagcctc  caaaggaag  cttcggtcc  ttaataggg  3780
tatgcagcc  actgaaagt  ctgacagct  agtcgaata  ggagaggga  accatggtc  3840
cttcagtga  gatggatca  ttattggtg  ctacgctgg  tctaaggag  agggatctg  3900
tgaaagcaa  ggaagttct  cagcaactt  tccccttcg  gcataaaca  aacatatgt  3960
agcaacgct  ctggttcac  ccaaccttc  atatttatc  gttcaaagg  gcaagaact  4020
tcatatagg  atagaaaca  gctggccga  gatttcatc  agaagtcaa  atcctgcaa  4080
tatgttgaa  agagtagta  tttcttcaa  atataaaat  ccaagcact  caggcctat  4140
ttttgctta  attgttttc  ggtgctcaa  atgcaaaac  caaaacaaa  cctgcattt  4200
gatacacct  aactaaatc  aaagtcccc  ttcagtata  tccatattt  cctgatttt  4260
ctattcggt  tgtttgcat  gatgttgct  cttggtggg  ttttctccg  atgcacatt  4320
gtatacagt  tctgagaac  ggcttggtg  ctttgcttc  ctacaggtt  aaagaccat  4380
agcaaactg  ttatttaaa  tgtaaaaag  aatatgaaa  tcttattaa  acacttcat  4440
gaaaatata  agtctaaat  tattattta  attttacta  caaaagtct  aggtgaaca  4500
tcaactagt  tttgttgag  tcctatttg  ccagagatg  tcatattta  acagaagta  4560
acgtttttc  gtttcaaca  gaatttttt  atttctgtc  gttatgaca  ccacgagca  4620
cactttttg  gtctgtttt  ttttttttc  tggactaaa  tcaactgca  ggaagcggt  4680
gtcagaagg  tgttttata  gagaacagg  agaaagtgc  cattgttca  gattctaat  4740
gctacatct  cttaatatc  tcatttcta  attgactgc  tttaccttt  tctcatgtt  4800
atataatgg  atgcttgca  atatttcat  aatacattg  acatattat  ttaatattt  4860
cacaattta  aatatagat  tgttttatt  tgaagtgag  aaatgaaca  taacaggca  4920
gtttgtaca  ctagaatat  ttagtaaga  actgttttt  gtcattcca  agctacaac  4980
aataacacg  ggttccaaa  ctgaagact  tgtataaag  atttgggtt  tgttcttgt  5040
ttgctttct  tcaacagtt  caaaataaa  tatcataca  atattgagg  aaatgtttt  5100
atatttttc  aaataggtt  ttattgttg  atgtacatc  accccagcc  ctcaaaaga  5160
aaactgttt  catagaaat  cctacacat  cgtttgcgt  tatgttatt  taaacatct  5220
tgtggtgag  attttttcc  cgatattct  cttctgtca  agtcagaac  aattcaggg  5280
atttatttt  tggcagttg  gctccagtc  ttttaaaat  gtacatgaa  atgttttag  5340
aacaatatg  aggatgatg  atacatgtc  gtcaagttc  gcgctcgac  ttttatgga  5400
agatttttt  aaccttacc  cgaaatact  aactactgt  taagtgaat  gacttattt  5460
actttagtt  ttgaactgt  attattggt  tactgttat  tcctcaact  ggatttatg  5520
taacccctt  tagttcatg  agaccaaaa  ttggggtat  tataatagt  agcgcagga  5580
tgcacatgg  atatctact  gtccttttg  acctcacga  tcatccaga  tgtatagac  5640
ggaaaagca  gtcttattt  aaactgtaa  ttatgggct  aggatctga  cgcagtccc  5700
ggagtaagc  tttcaaagg  ggaaggcag  gtggtccct  ccctgtgtg  atgtgagga  5760
gtagacatc  atcagtgca  ctcgagctc  atcctcctc  gatttctaa  gttccagtt  5820
tctggaggg  cagtcatca  gttttgatt  atctgggag  aaactgtgg  gcacagctt  5880
tgaggaggg  aaggttgtg  cgttcgagc  tagttctgg  gttattctg  ctcctcttc  5940
ttgtcatca  ccaaaacgt  gtttttaaa  agagtcatg  aggttagaa  taatgtcaa  6000
aatatttag  aatttaata  cctttaagt  agaaactaa  acaaatact  aaatattag  6060
tcttcctac  cttcgtgtt  ccctttagc  gcctgaaaa  caagattgc  cctactcag  6120
tcttctgag  ggctaaaac  tatggatat  aaaaatgag  ttgaatgat  actatgctt  6180
gctatcatt  ttacctttc  tcaatacta  ttggcaact  ctgggactc  tcagcacaa  6240
aggaataga  ctatgattg  ccctgattt  aattgtgaa  ttatatgat  catatattt  6300
atgaatcag  ataaccttc  aataaaata  atctaagtc  gttaaaatg  atttcatga  6360
tttccctca  aaaatgagt  acggagtcc  acggcgtgc  atggtaatt  taaattggt  6420
atgcttgtt  gcaaattgc  cactcgtga  aagtcaaca  ccaatattt  aaactttgt  6480
cgttactgg  tttacccta  ctttctcta  tctactgtc  atatcattt  aatgtaatt  6540
attgtatat  gtctcaaga  tggttggtg  gcatgagtt  ctagagaac  gtccaaggg  6600
tgggaaaat  caaattctc  tcctggctc  agcactgat  ttgtacata  acattaggc  6660
ggttgctta  cctttttat  tcaaactct  tcaactcta  agtgctaat  ataatctca  6720
ttaccttat  tttgtcaca  ggtgttctt  tttatgaag  aaaatttga  aatgataaa  6780
gctaagatg  cttctaact  cataagcaa  cctttaact  attatgtat  tgaaagtca  6840
ccccacata  caactcaac  tttttcctg  gaacacata  atatatttt  atagaaaaa  6900
aaatctaca  aaaataaat  tactgttta  tgagcagta  gacttgtac  tgccattga  6960
aattattaa  cagaagaaa  ttaagcagg  tctttgcta  acaaaagtg  tttccacta  7020
ttttgcatg  gtatttata  gaaaaatgt  aatttggtg  ttttattct  tcggtataa  7080
ggcatcgat  ttttagatg  acccgtgtt  gtaaaaatg  agagcacaa  ggaattatg  7140
tggaagtct  aaataatat  tttttccta  tttatactc  tggaagaga  aagctaaag  7200
ggggacaat  atgagaaat  ttggtgtgc  tttctaagc  tttaaaaca  aattgccaa  7260
tgaaaccct  aatatgttt  cataccatt  agatatgat  catgtaaca  tgttaaatt  7320
attataatg  gattgggtt  gttatctgt  gtagtatat  tcctagtgt  cctatagtg  7380
aataagtag  gttcagcca  agctttctt  gttttgtac  ttaaattgt  cgattacgt  7440
atcaaaaga  atgaaaggt  tgtagaaca  gttcacgtg  ttacctttt  cttttggct  7500
ggattaata  tcatagtag  actttataa  acgtgtttg  attgtaggt  gtgtttgta  7560
tatgcttat  actatgtat  gtttgaaaa  attttcatt  tacatgaaa  tcaactttc  7620
aaataaaag  tctacttca  gt  7642



<210> 1049
<211> 1224
<212> PRT
<213> Homo sapiens
<308> AAB60937
<400> 1049

Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
  1               5                  10                  15
Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
             20                  25                  30
Gln Val Pro Thr Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
         35                  40                  45
Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
     50                  55                  60
Pro Thr Phe Ser Trp Thr Lys Asp Gly Asn Pro Phe Tyr Phe Thr Asp 
 65                  70                  75                  80
His Arg Ile Ile Pro Ser Asn Asn Ser Gly Thr Phe Arg Ile Pro Asn 
                 85                  90                  95
Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser 
             100                105                110
Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro 
         115                120                125
Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu 
     130                135                140
Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro 
 145                150                155                160
Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln 
                 165                170                175
Asp Glu Arg Val Tyr Met Ser Gln Lys Gly Asp Leu Tyr Phe Ala Asn 
             180                185                190
Val Glu Glu Lys Asp Ser Arg Asn Asp Tyr Cys Cys Phe Ala Ala Phe 
         195                200                205
Pro Arg Leu Arg Thr Ile Val Gln Lys Met Pro Met Lys Leu Thr Val 
     210                215                220
Asn Ser Leu Lys His Ala Asn Asp Ser Ser Ser Ser Thr Glu Ile Gly 
 225                230                235                240
Ser Lys Ala Asn Ser Ile Lys Gln Arg Lys Pro Lys Leu Leu Leu Pro 
                 245                250                255
Pro Thr Glu Ser Gly Ser Glu Ser Ser Ile Thr Ile Leu Lys Gly Glu 
             260                265                270
Ile Leu Leu Leu Glu Cys Phe Ala Glu Gly Leu Pro Thr Pro Gln Val 
         275                280                285
Asp Trp Asn Lys Ile Gly Gly Asp Leu Pro Lys Gly Arg Glu Ala Lys 
     290                295                300
Glu Asn Tyr Gly Lys Thr Leu Lys Ile Glu Asn Val Ser Tyr Gln Asp 
 305                310                315                320
Lys Gly Asn Tyr Arg Cys Thr Ala Ser Asn Phe Leu Gly Thr Ala Thr 
                 325                330                335
His Asp Phe His Val Ile Val Glu Glu Pro Pro Arg Trp Thr Lys Lys 
             340                345                350
Pro Gln Ser Ala Val Tyr Ser Thr Gly Ser Asn Gly Ile Leu Leu Cys 
         355                360                365
Glu Ala Glu Gly Glu Pro Gln Pro Thr Ile Lys Trp Arg Val Asn Gly 
     370                375                380
Ser Pro Val Asp Asn His Pro Phe Ala Gly Asp Val Val Phe Pro Arg 
 385                390                395                400
Glu Ile Ser Phe Thr Asn Leu Gln Pro Asn His Thr Ala Val Tyr Gln 
                 405                410                415
Cys Glu Ala Ser Asn Val His Gly Thr Ile Leu Ala Asn Ala Asn Ile 
             420                425                430
Asp Val Val Asp Val Arg Pro Leu Ile Gln Thr Lys Asp Gly Glu Asn 
         435                440                445
Tyr Ala Thr Val Val Gly Tyr Ser Ala Phe Leu His Cys Glu Phe Phe 
     450                455                460
Ala Ser Pro Glu Ala Val Val Ser Trp Gln Lys Val Glu Glu Val Lys 
 465                470                475                480
Pro Leu Glu Gly Arg Arg Tyr His Ile Tyr Glu Asn Gly Thr Leu Gln 
                 485                490                495
Ile Asn Arg Thr Thr Glu Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val 
             500                505                510
Glu Asn Ala Ile Gly Lys Thr Ala Val Thr Ala Asn Leu Asp Ile Arg 
         515                520                525
Asn Ala Thr Lys Leu Arg Val Ser Pro Lys Asn Pro Arg Ile Pro Lys 
     530                535                540
Leu His Met Leu Glu Leu His Cys Glu Ser Lys Cys Asp Ser His Leu 
 545                550                555                560
Lys His Ser Leu Lys Leu Ser Trp Ser Lys Asp Gly Glu Ala Phe Glu 
                 565                570                575
Ile Asn Gly Thr Glu Asp Gly Arg Ile Ile Ile Asp Gly Ala Asn Leu 
             580                585                590
Thr Ile Ser Asn Val Thr Leu Glu Asp Gln Gly Ile Tyr Cys Cys Ser 
         595                600                605
Ala His Thr Ala Leu Asp Ser Ala Ala Asp Ile Thr Gln Val Thr Val 
     610                615                620
Leu Asp Val Pro Asp Pro Pro Glu Asn Leu His Leu Ser Glu Arg Gln 
 625                630                635                640
Asn Arg Ser Val Arg Leu Thr Trp Glu Ala Gly Ala Asp His Asn Ser 
                 645                650                655
Asn Ile Ser Glu Tyr Ile Val Glu Phe Glu Gly Asn Lys Glu Glu Pro 
             660                665                670
Gly Arg Trp Glu Glu Leu Thr Arg Val Gln Gly Lys Lys Thr Thr Val 
         675                680                685
Ile Leu Pro Leu Ala Pro Phe Val Arg Tyr Gln Phe Arg Val Ile Ala 
     690                695                700
Val Asn Glu Val Gly Arg Ser Gln Pro Ser Gln Pro Ser Asp His His 
 705                710                715                720
Glu Thr Pro Pro Ala Ala Pro Asp Arg Asn Pro Gln Asn Ile Arg Val 
                 725                730                735
Gln Ala Ser Gln Pro Lys Glu Met Ile Ile Lys Trp Glu Pro Leu Lys 
             740                745                750
Ser Met Glu Gln Asn Gly Pro Gly Leu Glu Tyr Arg Val Thr Trp Lys 
         755                760                765
Pro Gln Gly Ala Pro Val Glu Trp Glu Glu Glu Thr Val Thr Asn His 
     770                775                780
Thr Leu Arg Val Met Thr Pro Ala Val Tyr Ala Pro Tyr Asp Val Lys 
 785                790                795                800
Val Gln Ala Ile Asn Gln Leu Gly Ser Gly Pro Asp Pro Gln Ser Val 
                 805                810                815
Thr Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Thr Ala Pro Val Ile His 
             820                825                830
Gly Val Asp Val Ile Asn Ser Thr Leu Val Lys Val Thr Trp Ser Thr 
         835                840                845
Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr Gln Ile Asn 
     850                855                860
Trp Trp Lys Thr Lys Ser Leu Leu Asp Gly Arg Thr His Pro Lys Glu 
 865                870                875                880
Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly Met Val Pro 
                 885                890                895
Ser Leu Asp Ala Phe Ser Glu Phe His Leu Thr Val Leu Ala Tyr Asn 
             900                905                910
Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe Gln Thr Pro 
         915                920                925
Glu Gly Val Pro Glu Gln Pro Thr Phe Leu Lys Val Ile Lys Val Asp 
     930                935                940
Lys Asp Thr Ala Thr Leu Ser Trp Gly Leu Pro Lys Lys Leu Asn Gly 
 945                950                955                960
Asn Leu Thr Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn Asp Thr Tyr 
                 965                970                975
Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Thr Thr Pro Ser Lys Pro 
             980                985                990
Ser Trp His Leu Ser Asn Leu Asn Ala Thr Thr Lys Tyr Lys Phe Tyr 
         995                1000                1005
Leu Arg Ala Cys Thr Ser Gln Gly Cys Gly Lys Pro Ile Thr Glu Glu 
     1010                1015                1020
Ser Ser Thr Leu Gly Glu Gly Ser Lys Gly Ile Gly Lys Ile Ser Gly 
 1025                1030                1035                1040
Val Asn Leu Thr Gln Lys Thr His Pro Val Glu Val Phe Glu Pro Gly 
                 1045                1050                1055
Ala Glu His Ile Val Arg Leu Met Thr Lys Asn Trp Gly Asp Asn Asp 
             1060                1065                1070
Ser Ile Phe Gln Asp Val Ile Glu Thr Arg Gly Arg Glu Tyr Ala Gly 
         1075                1080                1085
Leu Tyr Asp Asp Ile Ser Thr Gln Gly Trp Phe Ile Gly Leu Met Cys 
     1090                1095                1100
Ala Ile Ala Leu Leu Thr Leu Leu Leu Leu Thr Val Cys Phe Val Lys 
 1105                1110                1115                1120
Arg Asn Arg Gly Gly Lys Tyr Ser Val Lys Glu Lys Glu Asp Leu His 
                 1125                1130                1135
Pro Asp Pro Glu Ile Gln Ser Val Lys Asp Glu Thr Phe Gly Glu Tyr 
             1140                1145                1150
Ser Asp Ser Asp Glu Lys Pro Leu Lys Gly Ser Leu Arg Ser Leu Asn 
         1155                1160                1165
Arg Asp Met Gln Pro Thr Glu Ser Ala Asp Ser Leu Val Glu Tyr Gly 
     1170                1175                1180
Glu Gly Asp His Gly Leu Phe Ser Glu Asp Gly Ser Phe Ile Gly Ala 
 1185                1190                1195                1200
Tyr Ala Gly Ser Lys Glu Lys Gly Ser Val Glu Ser Asn Gly Ser Ser 
                 1205                1210                1215
Thr Ala Thr Phe Pro Leu Arg Ala 
             1220



<210> 1051
<211> 208
<212> PRT
<213> Rattus norvegicus
<308> AAC25590
<400> 1051

Met Lys Val Leu Phe Ala Ala Ala Leu Ile Val Gly Ser Val Val Phe 
  1               5                  10                  15
Leu Leu Leu Pro Gly Pro Ser Val Ala Asn Asp Lys Lys Lys Gly Pro 
             20                  25                  30
Lys Val Thr Val Lys Val Tyr Phe Asp Phe Gln Ile Gly Asp Glu Pro 
         35                  40                  45
Val Gly Arg Val Thr Phe Gly Leu Phe Gly Lys Thr Val Pro Lys Thr 
     50                  55                  60
Val Asp Asn Phe Val Ala Leu Ala Thr Gly Glu Lys Gly Phe Gly Tyr 
 65                  70                  75                  80
Lys Asn Ser Lys Phe His Arg Val Ile Lys Asp Phe Met Ile Gln Gly 
                 85                  90                  95
Gly Asp Phe Thr Arg Gly Asp Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
             100                105                110
Glu Arg Phe Pro Asp Glu Asn Phe Lys Leu Lys His Tyr Gly Pro Gly 
         115                120                125
Trp Val Ser Met Ala Asn Ala Gly Lys Asp Thr Asn Gly Ser Gln Phe 
     130                135                140
Phe Ile Thr Thr Val Lys Thr Ser Trp Leu Asp Gly Lys His Val Val 
 145                150                155                160
Phe Gly Lys Val Leu Glu Gly Met Asp Val Val Arg Lys Val Glu Asn 
                 165                170                175
Thr Lys Thr Asp Ser Arg Asp Lys Pro Leu Lys Asp Val Ile Ile Val 
             180                185                190
Asp Cys Gly Lys Ile Glu Val Glu Lys Pro Phe Ala Ile Ala Lys Glu 
         195                200                205



<210> 1052
<211> 1028
<212> DNA
<213> Homo sapiens
<308> NM_000942
<400> 1052

ggcacgagg  cggcgcccg  cgcccgccc  gagcccgcg  gcaacccca  tccccccca  900
ccgcgcgtg  cggcgccgg  tccctagcc  ccgcggccc  accctcttc  ggcctcagc  960
gtccgggct  ctttcgcct  cgcctgtgg  tgctgcgcc  ctccgaacg  aacatgaag  1020
tgctcctt  1028



<210> 1053
<211> 208
<212> PRT
<213> Homo sapiens
<308> P23284
<400> 1053

Met Lys Val Leu Leu Ala Ala Ala Leu Ile Ala Gly Ser Val Phe Phe 
  1               5                  10                  15
Leu Leu Leu Pro Gly Pro Ser Ala Ala Asp Glu Lys Lys Lys Gly Pro 
             20                  25                  30
Lys Val Thr Val Lys Val Tyr Phe Asp Leu Arg Ile Gly Asp Glu Asp 
         35                  40                  45
Val Gly Arg Val Ile Phe Gly Leu Phe Gly Lys Thr Val Pro Lys Thr 
     50                  55                  60
Val Asp Asn Phe Val Ala Leu Ala Thr Gly Glu Lys Gly Phe Gly Tyr 
 65                  70                  75                  80
Lys Asn Ser Lys Phe His Arg Val Ile Lys Asp Phe Met Ile Gln Gly 
                 85                  90                  95
Gly Asp Phe Thr Arg Gly Asp Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
             100                105                110
Glu Arg Phe Pro Asp Glu Asn Phe Lys Leu Lys His Tyr Gly Pro Gly 
         115                120                125
Trp Val Ser Met Ala Asn Ala Gly Lys Asp Thr Asn Gly Ser Gln Phe 
     130                135                140
Phe Ile Thr Thr Val Lys Thr Ala Trp Leu Asp Gly Lys His Val Val 
 145                150                155                160
Phe Gly Lys Val Leu Glu Gly Met Glu Val Val Arg Lys Val Glu Ser 
                 165                170                175
Thr Lys Thr Asp Ser Arg Asp Lys Pro Leu Lys Asp Val Ile Ile Ala 
             180                185                190
Asp Cys Gly Lys Ile Glu Val Glu Lys Pro Phe Ala Ile Ala Lys Glu 
         195                200                205



<210> 1054
<211> 1590
<212> DNA
<213> Rattus norvegicus
<308> AF071495
<400> 1054

cacgcggac  tgggcggca  ctccagggc  cgctgggtg  ccttggggc  gggcgttct  60
gggctgctg  gtgctgcgc  cggcgttat  gtgattctc  tggtgccct  gctcatcaa  120
cagcaggtg  tcaagaatg  ccgcataga  cccagcagc  tgtcctttg  gatgtggaa  180
gagatccct  ttcccttct  cttgtccgt  tacttcttc  aggtggtca  ccccagcga  240
gtcctaaat  gccagaagc  agtagtccg  gagcgcgga  cctatgtct  cagggagtt  300
agacaaaag  ttaacatca  cttcaatga  aatgacacg  tgtcctaca  agagaaccg  360
agccttcat  tccagccag  caggtccca  ggctcagag  gtgactaca  tgtactgcc  420
aacatcctg  tcctgggag  ggcagtgat  atggaggac  agcccacaa  cctgaagct  480
ctaatgacc  tggggttgg  caccatggg  cagcgggcc  ttatgaacc  cacggttgg  540
gagatcctg  ggggctatg  ggatccgtt  gtgaatttc  tcagcaaat  tttcccaga  600
atgttcccc  tcaaaggca  atttggcct  ttcgttggg  tgaaccact  agagttctg  660
ctcttcacc  tcttacagg  tgtccagaa  ttcagcaag  tccatctgg  ggataagtg  720
aacggcctc  gcgaggtca  atattggca  tcggaacag  gcaacatga  caatggtac  780
gccgggcag  tgtgggcac  attcatgac  cccgaatcc  cactggaat  cttcagccc  840
gaagcctgc  gatctatga  gctcaccta  caggaatca  gggtgttcg  aggcatccc  900
acttatcgc  tcacggccc  cgatacttt  tttgccaac  ggtccgtct  cccacctaa  960
gaaggcttc  gcccgtgcc  cgagtccgg  attcagaat  tcagcacct  caggtttgg  1020
gcgcccctg  ttctctccc  gccccactt  tacaatgct  accccgtgc  gtcagaagc  1080
gttcttggt  tgaaccctg  cccaaggga  cattctttg  tccttgaca  ccacccggt  1140
actgggatc  ccatgaact  ttccgtgaa  atgcagctg  gtctgtaca  caaatccgt  1200
aagggcgtc  ggcaaacag  gaagatcga  ccagtagtc  tgccattgc  gtggttcga  1260
cagagcggg  tgatgggtg  caagaccct  aacacgttc  acacgcagc  ggtgctgat  1320
ccccaggtt  ttcactacg  gcagtatgt  ctgctgggg  ttggaggcc  cctgctgct  1380
gtgcccatc  tttaccaac  gcgcagcca  gagaaatgc  ttttatttt  gagtggtag  1440
aaaaagggc  cgcaggata  ggaggccat  caggcctac  ctgagtctc  gatgtcacc  1500
gctgccaag  gcacggtag  gcaagaagc  aagctgtag  gcccagaag  caccacgag  1560
cccccaaac  tgatagctt  gtcagaccag  1590



<210> 1055
<211> 509
<212> PRT
<213> Rattus norvegicus
<308> AAC23892
<400> 1055

Met Gly Gly Ser Ser Arg Ala Arg Trp Val Ala Leu Gly Leu Gly Val 
  1               5                  10                  15
Leu Gly Leu Leu Cys Ala Ala Leu Gly Val Ile Val Ile Leu Met Val 
             20                  25                  30
Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
         35                  40                  45
Ser Ser Leu Ser Phe Gly Met Trp Lys Glu Ile Pro Val Pro Phe Tyr 
     50                  55                  60
Leu Ser Val Tyr Phe Phe Glu Val Val Asn Pro Ser Glu Val Leu Asn 
 65                  70                  75                  80
Gly Gln Lys Pro Val Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                 85                  90                  95
Phe Arg Gln Lys Val Asn Ile Thr Phe Asn Asp Asn Asp Thr Val Ser 
             100                105                110
Tyr Ile Glu Asn Arg Ser Leu His Phe Gln Pro Asp Arg Ser Gln Gly 
         115                120                125
Ser Glu Ser Asp Tyr Ile Val Leu Pro Asn Ile Leu Val Leu Gly Gly 
     130                135                140
Ala Val Met Met Glu Asp Lys Pro Thr Ser Leu Lys Leu Leu Met Thr 
 145                150                155                160
Leu Gly Leu Val Thr Met Gly Gln Arg Ala Phe Met Asn Arg Thr Val 
                 165                170                175
Gly Glu Ile Leu Trp Gly Tyr Glu Asp Pro Phe Val Asn Phe Leu Ser 
             180                185                190
Lys Tyr Phe Pro Asp Met Phe Pro Ile Lys Gly Lys Phe Gly Leu Phe 
         195                200                205
Val Gly Met Asn His Ser Glu Phe Trp Leu Phe Thr Val Leu Gln Gly 
     210                215                220
Val Gln Asn Phe Ser Lys Ile His Leu Val Asp Lys Trp Asn Gly Leu 
 225                230                235                240
Ser Glu Val Lys Tyr Trp His Ser Glu Gln Cys Asn Met Ile Asn Gly 
                 245                250                255
Thr Ala Gly Gln Met Trp Ala Pro Phe Met Thr Pro Glu Ser Ser Leu 
             260                265                270
Glu Phe Phe Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Thr Tyr Gln 
         275                280                285
Glu Ser Arg Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Thr Ala Pro 
     290                295                300
Asp Thr Leu Phe Ala Asn Gly Ser Val Tyr Pro Pro Asn Glu Gly Phe 
 305                310                315                320
Cys Pro Cys Arg Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                 325                330                335
Gly Ala Pro Leu Phe Leu Ser Gln Pro His Phe Tyr Asn Ala Asp Pro 
             340                345                350
Val Leu Ser Glu Ala Val Leu Gly Leu Asn Pro Asp Pro Arg Glu His 
         355                360                365
Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
     370                375                380
Ser Val Lys Met Gln Leu Ser Leu Tyr Ile Lys Ser Val Lys Gly Val 
 385                390                395                400
Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                 405                410                415
Glu Gln Ser Gly Met Met Gly Gly Lys Thr Leu Asn Thr Phe Tyr Thr 
             420                425                430
Gln Leu Val Leu Met Pro Gln Val Leu His Tyr Ala Gln Tyr Val Leu 
         435                440                445
Leu Gly Leu Gly Gly Leu Leu Leu Leu Val Pro Ile Ile Tyr Gln Leu 
     450                455                460
Arg Ser Gln Glu Lys Cys Phe Leu Phe Trp Ser Gly Ser Lys Lys Gly 
 465                470                475                480
Ser Gln Asp Lys Glu Ala Met Gln Ala Tyr Ser Glu Ser Leu Met Ser 
                 485                490                495
Pro Ala Ala Lys Gly Thr Val Val Gln Glu Ala Lys Leu 
             500                505



<210> 1056
<211> 2751
<212> DNA
<213> Homo sapiens
<308> NM_005505
<400> 1056

ggcacgagg  cggatccac  gtgcctctg  ggcctgcgt  cccggagtc  ccgcctgtg  60
cgtctctgt  gccgtcccc  tctcctgcc  ggcgcggag  cctgcgagc  gcgggtggg  120
cccaggcgc  cagacatgg  ctgctccgc  aaagcgcgc  gggctgccg  ggcgctggg  180
gtcgcgggg  tactgtgcg  tgtgctggg  gctgtcatg  tcgtgatgg  gccgtcgct  240
atcaagcag  aggtcctta  gaacgtgcg  atcgacccc  gtagcctgt  cttcaacat  300
tggaaggag  tccctatcc  cttctatct  tccgtctac  tctttgacg  catgaaccc  360
agcgagatc  tgaagggcg  gaagccgca  gtgcgggag  gcgggccct  cgtgtacag  420
gagttcagg  acaaaagca  catcacctt  aacaacaac  acaccgtgt  cttcctcga  480
taccgcacc  tccagttcc  gccctccaa  tcccacggc  cggagagcg  ctacatcgt  540
atgcccaac  tcctggtct  gggtgcggc  gtgatgatg  agaataagc  catgaccct  600
aagctcatc  tgaccttgg  attcaccac  ctcggcgaa  gtgccttca  gaaccgcac  660
gtgggtgag  tcatgtggg  ctacaagga  ccccttgtg  atctcatca  caagtactt  720
ccaggcatg  tccccttca  ggacaagtt  ggattattt  ctgagctca  caactccga  780
tctgggctc  tcacggtgt  cacgggggt  cagaacatc  gcaggatcc  cctcgtgga  840
aagtggaac  ggctgagca  ggttgactt  tggcattcc  atcagtgca  catgatcaa  900
ggaacttct  ggcaaatgt  gccgccctt  atgactcct  agtcctcgc  ggagttcta  960
agcccggag  cctgccgat  catgaagct  atgtacaag  agtcagggg  gtttgaagg  1020
atccccacc  atcgcttcg  ggctcccaa  accctgttt  ccaacgggt  catctaccc  1080
cccaacgaa  gcttctgcc  gtgcctgga  tctggaatt  agaacgtca  cacctgcag  1140
ttcagtgcc  ccttgtttc  ctcccatcc  cacttcctc  acgccgacc  ggttctggc  1200
gaagcggtg  ctggcctgc  ccctaacca  gaggcacac  ccttgttcc  ggacatcca  1260
ccggtcacg  gaatcccca  gaactgctc  gtgaaactg  agctgagcc  ctacatgaa  1320
tctgtcgca  gcattggac  aactgggaa  attgagcct  tggtcctgc  gctgctctg  1380
tttgcagag  gcggggcca  ggaggggga  actcttcac  cattctaca  tcagctggt  1440
ttgatgccc  aggtgatgc  ctatgccca  tacgtcctc  tggcgctgg  ctgcgtcct  1500
ctgctggtc  ctgtcatct  ccaaatccg  agccaagta  gtgctggcc  gagggcagc  1560
cgggctgac  gccattcgc  tgcctgctg  gggaaaggg  cctcagatc  gaccctctg  1620
ccaaccgca  cctggagcc  acctccagc  gcagtcctg  gtctctgcc  gagtgggag  1680
ggtcactgc  gggggctgc  cagcacgct  gcgtctttt  catgccgcg  tgccactac  1740
ctgcctgtt  tggaaggcc  gggaccctc  cttggaggg  gcacagggt  ctgaggaca  1800
cgtgagcca  ccaggcctg  ccgctgggc  tgaccggcc  cccagcccc  acaccccgc  1860
tctcccgga  tctcccagc  gacagcccc  cagccccac  gcctgagcc  cccagctgc  1920
atgtgcctg  tgcacacct  cacacacgc  ctggcacac  tacacacat  cgtgcaggc  1980
tgtgcagac  ctcagggat  gagctgctg  tgaagggac  tgtagggag  ggctcgtca  2040
caagcactg  tctggaacc  tctctccac  tggcccaca  gcctgacca  aggggctgt  2100
ggtcctgcg  ccccttcct  gggtgagcc  ggcctgtcc  gttcagccg  tgggcccag  2160
cttcctccc  tccaaggtg  aacactgca  tcccggtgt  gtggctccc  atgcaggac  2220
ggccaggct  ggagtgccg  cttcctgtg  caaattcag  ggggactca  tgcccaggc  2280
ctggccacg  gctttggcc  tggtctacc  gccaggcca  gcaaagcgc  tttacacag  2340
cctcggaaa  caatggagt  agcacaaga  gccctgtgc  gctgcccga  ggtctccgc  2400
caccccggc  ggactttga  ccccccgaa  tcttcacag  cactgcatc  ggttgtctg  2460
cgccctttt  ctccagcct  aactgacat  atcctatgg  ctgagccgg  cactctctg  2520
ccgaagtgg  cgcaggctg  gcccccgag  tgcccccac  ccctcacag  gtccctcag  2580
ttataggtg  ccaggctga  gtgaagagg  ctgggggcc  tgccttccg  gcgctcctg  2640
accctgggg  aaacctgtg  cccttttct  ctggaatag  aatgagttt  atcatcttt  2700
aaaaataat  cactcttga  gtaataaac  tttaaaaaa  aaaaaaaaa  a  2751



<210> 1057
<211> 552
<212> PRT
<213> Homo sapiens
<308> NP_005496
<400> 1057

Met Gly Cys Ser Ala Lys Ala Arg Trp Ala Ala Gly Ala Leu Gly Val 
  1               5                  10                  15
Ala Gly Leu Leu Cys Ala Val Leu Gly Ala Val Met Ile Val Met Val 
             20                  25                  30
Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
         35                  40                  45
Ser Ser Leu Ser Phe Asn Met Trp Lys Glu Ile Pro Ile Pro Phe Tyr 
     50                  55                  60
Leu Ser Val Tyr Phe Phe Asp Val Met Asn Pro Ser Glu Ile Leu Lys 
 65                  70                  75                  80
Gly Glu Lys Pro Gln Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                 85                  90                  95
Phe Arg His Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp Thr Val Ser 
             100                105                110
Phe Leu Glu Tyr Arg Thr Phe Gln Phe Gln Pro Ser Lys Ser His Gly 
         115                120                125
Ser Glu Ser Asp Tyr Ile Val Met Pro Asn Ile Leu Val Leu Gly Ala 
     130                135                140
Ala Val Met Met Glu Asn Lys Pro Met Thr Leu Lys Leu Ile Met Thr 
 145                150                155                160
Leu Ala Phe Thr Thr Leu Gly Glu Arg Ala Phe Met Asn Arg Thr Val 
                 165                170                175
Gly Glu Ile Met Trp Gly Tyr Lys Asp Pro Leu Val Asn Leu Ile Asn 
             180                185                190
Lys Tyr Phe Pro Gly Met Phe Pro Phe Lys Asp Lys Phe Gly Leu Phe 
         195                200                205
Ala Glu Leu Asn Asn Ser Asp Ser Gly Leu Phe Thr Val Phe Thr Gly 
     210                215                220
Val Gln Asn Ile Ser Arg Ile His Leu Val Asp Lys Trp Asn Gly Leu 
 225                230                235                240
Ser Lys Val Asp Phe Trp His Ser Asp Gln Cys Asn Met Ile Asn Gly 
                 245                250                255
Thr Ser Gly Gln Met Trp Pro Pro Phe Met Thr Pro Glu Ser Ser Leu 
             260                265                270
Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Met Tyr Lys 
         275                280                285
Glu Ser Gly Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Val Ala Pro 
     290                295                300
Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn Glu Gly Phe 
 305                310                315                320
Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                 325                330                335
Ser Ala Pro Leu Phe Leu Ser His Pro His Phe Leu Asn Ala Asp Pro 
             340                345                350
Val Leu Ala Glu Ala Val Thr Gly Leu His Pro Asn Gln Glu Ala His 
         355                360                365
Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
     370                375                380
Ser Val Lys Leu Gln Leu Ser Leu Tyr Met Lys Ser Val Ala Gly Ile 
 385                390                395                400
Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                 405                410                415
Ala Glu Ser Gly Ala Met Glu Gly Glu Thr Leu His Thr Phe Tyr Thr 
             420                425                430
Gln Leu Val Leu Met Pro Lys Val Met His Tyr Ala Gln Tyr Val Leu 
         435                440                445
Leu Ala Leu Gly Cys Val Leu Leu Leu Val Pro Val Ile Cys Gln Ile 
     450                455                460
Arg Ser Gln Val Gly Ala Gly Gln Arg Ala Ala Arg Ala Asp Ser His 
 465                470                475                480
Ser Leu Ala Cys Trp Gly Lys Gly Ala Ser Asp Arg Thr Leu Trp Pro 
                 485                490                495
Thr Ala Ala Trp Ser Pro Pro Pro Ala Ala Val Leu Arg Leu Cys Arg 
             500                505                510
Ser Gly Ser Gly His Cys Trp Gly Leu Arg Ser Thr Leu Ala Ser Phe 
         515                520                525
Ala Cys Arg Val Ala Thr Thr Leu Pro Val Leu Glu Gly Leu Gly Pro 
     530                535                540
Ser Leu Gly Gly Gly Thr Gly Ser 
 545                550



<210> 1058
<211> 1469
<212> DNA
<213> Rattus norvegicus
<308> AF072411
<400> 1058

tgattctgc  gcacgagga  gagaatggg  tgcgatcgg  actgtgggc  cattactgg  60
gccgttatt  gtgctgtcc  ggctgtgtt  ggaggcatt  tcatgccgg  tggagacct  120
ctcattgag  agacaatca  aagggaagt  gtccttgaa  aaggaacca  tgctttcaa  180
aactgggtg  aaacgggca  cactgtgta  agacagttt  ggatctttg  cgtgcaaaa  240
ccagaggaa  tggcaaaga  tagcagcaa  atcaaggtt  aacagagag  tccttacac  300
tacagagtt  gttatttag  caaggaaaa  ataactcag  accccaagg  cagcactgt  360
tcttttgta  aacccaatg  agccatctt  gagccttca  tgtctgttg  aacagagaa  420
gacaacttc  cagttctca  tctggctgt  gcagctgca  cacatatct  cacaaactc  480
tttgttcaa  gtgtgctca  cagccttat  aaaaagtcc  agtcttcta  gttccaaac  540
cgaagtttg  aggaactct  gtggggtta  aaagatcca  tcttgagtt  ggttccata  600
cctataagt  ccacagttg  tgtgtttta  ccttacaat  acactgtag  tggagttta  660
aaagttttc  atggaaagg  taacataag  aaggttgcc  taattgata  ctataaagg  720
aaaaggaat  tgtcctatt  ggaaagtta  tgcgacatg  ttaatggca  agatgcagc  780
tcctttcca  cttttgttg  gaagtctca  acactgagg  tcttttcct  tgacatttg  840
aggtccatc  atgctgtgt  tgaatctga  gtgaacctt  aaggaatcc  cgtatacag  900
tttgttctt  cagccaacg  ctttgcctc  ccactccag  acccagaca  ccactgttt  960
tgcactgaa  aagtaatct  aaataactg  acgtcgtat  gtgtgctgg  cattggcaa  1020
tgcaaagaa  gaaagcctg  gtacatttc  cttccacat  tcctacatg  aagtcctga  1080
gtctcagaa  ctatcgaag  cttgaatcc  aacgaagat  agcatagga  atacttgga  1140
gtggaaccc  taactggat  cactctaca  tttgcaaaa  gactgcagg  caacatact  1200
gtcaagcca  ctagaaaaa  agaagcact  aagaatctg  agagacctt  cattgtacc  1260
atactgtgg  taaatgaga  tgggaccat  ggcgatgag  aagcagaaa  gttcagaaa  1320
caagtgacc  ggaaaataa  gctcctggg  ctggttgag  tggtcttac  tggtgttgg  1380
gtagtgatg  ttgttgctt  tatgatttc  tactgtgct  gcagatcta  gaatggaaa  1440
taagtagtg  atgagccta  attatgcac  1469



<210> 1059
<211> 471
<212> PRT
<213> Rattus norvegicus
<308> Q07969
<400> 1059

Gly Cys Asp Arg Asn Cys Gly Leu Ile Thr Gly Ala Val Ile Gly Ala 
  1               5                  10                  15
Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu Leu 
             20                  25                  30
Ile Glu Lys Thr Ile Lys Arg Glu Val Val Leu Glu Glu Gly Thr Ile 
         35                  40                  45
Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Thr Val Tyr Arg Gln Phe 
     50                  55                  60
Trp Val Phe Asp Val Gln Asn Pro Glu Glu Val Ala Lys Asn Ser Ser 
 65                  70                  75                  80
Lys Ile Lys Val Ile Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg Tyr 
                 85                  90                  95
Leu Ala Lys Glu Asn Ile Thr Gln Asp Pro Lys Asp Ser Thr Val Ser 
             100                105                110
Phe Val Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val Gly 
         115                120                125
Thr Glu Asn Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala Ala 
     130                135                140
Pro His Ile Tyr Thr Asn Ser Phe Val Gln Gly Val Leu Asn Ser Leu 
 145                150                155                160
Ile Lys Lys Ser Lys Ser Ser Met Phe Gln Thr Arg Ser Leu Lys Glu 
                 165                170                175
Leu Leu Trp Gly Tyr Lys Asp Pro Phe Leu Ser Leu Val Pro Tyr Pro 
             180                185                190
Ile Ser Thr Thr Val Gly Val Phe Tyr Pro Tyr Asn Asn Thr Val Asp 
         195                200                205
Gly Val Tyr Lys Val Ser Asn Gly Lys Asp Asn Ile Ser Lys Val Ala 
     210                215                220
Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu Ser 
 225                230                235                240
Tyr Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro Leu 
                 245                250                255
Gly Glu Lys Ser Arg Thr Leu Arg Phe Phe Ser Ser Asp Ile Cys Arg 
             260                265                270
Ser Ile Tyr Ala Val Phe Glu Ser Glu Val Asn Leu Lys Gly Ile Pro 
         275                280                285
Val Tyr Arg Phe Val Leu Pro Ala Asn Ala Phe Ala Ser Pro Leu Gln 
     290                295                300
Asn Pro Asp Asn His Cys Phe Cys Thr Glu Lys Val Ile Ser Asn Asn 
 305                310                315                320
Cys Thr Ser Tyr Gly Val Leu Asp Ile Gly Lys Cys Lys Glu Gly Lys 
                 325                330                335
Pro Val Tyr Asn Ser Leu Pro His Phe Leu His Ala Ser Pro Asp Val 
             340                345                350
Ser Glu Pro Ile Glu Gly Leu Asn Pro Thr Glu Asp Glu His Arg Thr 
         355                360                365
Tyr Leu Asp Val Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ser Lys 
     370                375                380
Arg Leu Gln Val Asn Ile Leu Val Lys Pro Ala Arg Lys Ile Glu Ala 
 385                390                395                400
Leu Lys Asn Leu Lys Arg Pro Tyr Ile Val Pro Ile Leu Trp Leu Asn 
                 405                410                415
Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Glu Met Phe Arg Asn Gln 
             420                425                430
Val Thr Gly Lys Ile Lys Leu Leu Gly Leu Val Glu Met Val Leu Leu 
         435                440                445
Gly Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys Ala 
     450                455                460
Cys Arg Ser Lys Asn Gly Lys 
 465                470



<210> 1060
<211> 1749
<212> DNA
<213> Homo sapiens
<308> BC008406
<400> 1060

gaggactgc  gtgtaggac  ttcctgcag  ataccattt  atcctatta  gaattgtcc  60
aatgttgga  catttgatt  aaaaatcct  cttagccat  ttaaagata  ctttccaat  120
attagacga  ttgattctt  ctgtgactc  tcagttcat  tcctgtaaa  ttcatgtct  180
gctgttgat  tgtgaataa  aaccagagc  tgtagaaac  actttaatc  tatccagga  240
tttgcaaga  acaggtgct  aacactaat  cacctcctg  acaagaaaa  tgggctgtg  300
ccggaactg  gggctcatc  ctggggctg  cattggtgc  gtcctggct  tgtttggag  360
tattctaat  ccagttgga  acctgctta  ccagaagac  attaaaaag  aagttgtcc  420
cgaagaagg  acaattgct  ttaaaaatt  ggttaaaac  ggcacagaa  tttacagac  480
gttttggat  tttgatgtg  aaaatccac  ggaagtgat  atgaacagc  gcaacattc  540
agttaagca  agaggtcct  atacgtaca  agttcgttt  ctagccaag  aaaatgtaa  600
ccaggacgc  gaggacaac  cagtctctt  cctgcagcc  aatggtgcc  tcttcgaac  660
ttcactatc  gttggaaca  aggctgaca  cttcacagt  ctcaatctg  ctgtggcag  720
tgcatccca  atctatcaa  atcaatttg  tcaaatgat  ctcaattca  ttattaaca  780
gtcaaaatc  tctatgttc  aagtcagaa  tttgagaga  ctgttatgg  gctataggg  840
tccattttt  agtttggtt  cataccctg  tactaccac  gttggtctg  tttatcctt  900
caacaatac  gcagatgga  tttataaag  tttcaatgg  aaagataac  taagtaaag  960
tgccataat  gacacatat  aaggtaaaa  gaatctgtc  tattgggaa  gtcactgcg  1020
catgattaa  ggtacagat  cagcctcat  tccaccttt  gttgagaaa  gccaggtat  1080
gcagttctt  tcttctgat  tttgcaggt  aatctatgc  gtatttgaa  ccgacgtta  1140
tctgaaagg  atccctgtg  atagatttg  tcttccatc  aaggccttt  cctctccag  1200
tgaaaaccc  gacaactat  gtttctgca  agaaaaaat  atctcaaaa  attgtacat  1260
atatggtgt  ctagacatc  gcaaatgca  agaagggag  cctgtgtac  tttcacttc  1320
tcattttct  tatgcaagt  ctgatgttt  agaacctat  gatggatta  acccaaatg  1380
agaagaaca  aggacatac  tggatattg  acctataac  ggattcact  tacaatttg  1440
aaaacggct  caggtcaac  tattggtca  gccatcaga  aaaattcaa  tattaaaga  1500
tctgaagag  aactatatt  tgcctattc  ttggcttaa  gagactggg  ccattggtg  1560
tgagaaggc  aacatgttc  gaagtcaag  aactggaaa  ataaacctc  ttggcctga  1620
agaaatgat  ttactcagt  ttggtgtgg  gatgtttgt  gcttttatg  tttcatatt  1680
tgcatgcag  tcgaaaaca  taaaataag  aagtatgta  caaaaaaaa  aaaaaaaaa  1740
aaaaaaaaa  1749



<210> 1061
<211> 471
<212> PRT
<213> Homo sapiens
<308> P16671
<400> 1061

Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly Ala 
  1               5                  10                  15
Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu Leu 
             20                  25                  30
Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr Ile 
         35                  40                  45
Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln Phe 
     50                  55                  60
Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser Ser 
 65                  70                  75                  80
Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg Phe 
                 85                  90                  95
Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val Ser 
             100                105                110
Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val Gly 
         115                120                125
Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala Ala 
     130                135                140
Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser Leu 
 145                150                155                160
Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg Glu 
                 165                170                175
Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr Pro 
             180                185                190
Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala Asp 
         195                200                205
Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val Ala 
     210                215                220
Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu Ser 
 225                230                235                240
His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro Phe 
                 245                250                255
Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys Arg 
             260                265                270
Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile Pro 
         275                280                285
Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val Glu 
     290                295                300
Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys Asn 
 305                310                315                320
Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly Arg 
                 325                330                335
Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp Val 
             340                345                350
Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg Thr 
         355                360                365
Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala Lys 
     370                375                380
Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln Val 
 385                390                395                400
Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu Asn 
                 405                410                415
Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser Gln 
             420                425                430
Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu Leu 
         435                440                445
Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys Ala 
     450                455                460
Cys Arg Ser Lys Thr Ile Lys 
 465                470



<210> 1062
<211> 1469
<212> DNA
<213> Rattus norvegicus
<308> AF072411
<400> 1062

tgattctgc  gcacgagga  gagaatggg  tgcgatcgg  actgtgggc  cattactgg  60
gccgttatt  gtgctgtcc  ggctgtgtt  ggaggcatt  tcatgccgg  tggagacct  120
ctcattgag  agacaatca  aagggaagt  gtccttgaa  aaggaacca  tgctttcaa  180
aactgggtg  aaacgggca  cactgtgta  agacagttt  ggatctttg  cgtgcaaaa  240
ccagaggaa  tggcaaaga  tagcagcaa  atcaaggtt  aacagagag  tccttacac  300
tacagagtt  gttatttag  caaggaaaa  ataactcag  accccaagg  cagcactgt  360
tcttttgta  aacccaatg  agccatctt  gagccttca  tgtctgttg  aacagagaa  420
gacaacttc  cagttctca  tctggctgt  gcagctgca  cacatatct  cacaaactc  480
tttgttcaa  gtgtgctca  cagccttat  aaaaagtcc  agtcttcta  gttccaaac  540
cgaagtttg  aggaactct  gtggggtta  aaagatcca  tcttgagtt  ggttccata  600
cctataagt  ccacagttg  tgtgtttta  ccttacaat  acactgtag  tggagttta  660
aaagttttc  atggaaagg  taacataag  aaggttgcc  taattgata  ctataaagg  720
aaaaggaat  tgtcctatt  ggaaagtta  tgcgacatg  ttaatggca  agatgcagc  780
tcctttcca  cttttgttg  gaagtctca  acactgagg  tcttttcct  tgacatttg  840
aggtccatc  atgctgtgt  tgaatctga  gtgaacctt  aaggaatcc  cgtatacag  900
tttgttctt  cagccaacg  ctttgcctc  ccactccag  acccagaca  ccactgttt  960
tgcactgaa  aagtaatct  aaataactg  acgtcgtat  gtgtgctgg  cattggcaa  1020
tgcaaagaa  gaaagcctg  gtacatttc  cttccacat  tcctacatg  aagtcctga  1080
gtctcagaa  ctatcgaag  cttgaatcc  aacgaagat  agcatagga  atacttgga  1140
gtggaaccc  taactggat  cactctaca  tttgcaaaa  gactgcagg  caacatact  1200
gtcaagcca  ctagaaaaa  agaagcact  aagaatctg  agagacctt  cattgtacc  1260
atactgtgg  taaatgaga  tgggaccat  ggcgatgag  aagcagaaa  gttcagaaa  1320
caagtgacc  ggaaaataa  gctcctggg  ctggttgag  tggtcttac  tggtgttgg  1380
gtagtgatg  ttgttgctt  tatgatttc  tactgtgct  gcagatcta  gaatggaaa  1440
taagtagtg  atgagccta  attatgcac  1469



<210> 1063
<211> 471
<212> PRT
<213> Rattus norvegicus
<308> Q07969
<400> 1063

Gly Cys Asp Arg Asn Cys Gly Leu Ile Thr Gly Ala Val Ile Gly Ala 
  1               5                  10                  15
Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu Leu 
             20                  25                  30
Ile Glu Lys Thr Ile Lys Arg Glu Val Val Leu Glu Glu Gly Thr Ile 
         35                  40                  45
Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Thr Val Tyr Arg Gln Phe 
     50                  55                  60
Trp Val Phe Asp Val Gln Asn Pro Glu Glu Val Ala Lys Asn Ser Ser 
 65                  70                  75                  80
Lys Ile Lys Val Ile Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg Tyr 
                 85                  90                  95
Leu Ala Lys Glu Asn Ile Thr Gln Asp Pro Lys Asp Ser Thr Val Ser 
             100                105                110
Phe Val Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val Gly 
         115                120                125
Thr Glu Asn Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala Ala 
     130                135                140
Pro His Ile Tyr Thr Asn Ser Phe Val Gln Gly Val Leu Asn Ser Leu 
 145                150                155                160
Ile Lys Lys Ser Lys Ser Ser Met Phe Gln Thr Arg Ser Leu Lys Glu 
                 165                170                175
Leu Leu Trp Gly Tyr Lys Asp Pro Phe Leu Ser Leu Val Pro Tyr Pro 
             180                185                190
Ile Ser Thr Thr Val Gly Val Phe Tyr Pro Tyr Asn Asn Thr Val Asp 
         195                200                205
Gly Val Tyr Lys Val Ser Asn Gly Lys Asp Asn Ile Ser Lys Val Ala 
     210                215                220
Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu Ser 
 225                230                235                240
Tyr Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro Leu 
                 245                250                255
Gly Glu Lys Ser Arg Thr Leu Arg Phe Phe Ser Ser Asp Ile Cys Arg 
             260                265                270
Ser Ile Tyr Ala Val Phe Glu Ser Glu Val Asn Leu Lys Gly Ile Pro 
         275                280                285
Val Tyr Arg Phe Val Leu Pro Ala Asn Ala Phe Ala Ser Pro Leu Gln 
     290                295                300
Asn Pro Asp Asn His Cys Phe Cys Thr Glu Lys Val Ile Ser Asn Asn 
 305                310                315                320
Cys Thr Ser Tyr Gly Val Leu Asp Ile Gly Lys Cys Lys Glu Gly Lys 
                 325                330                335
Pro Val Tyr Asn Ser Leu Pro His Phe Leu His Ala Ser Pro Asp Val 
             340                345                350
Ser Glu Pro Ile Glu Gly Leu Asn Pro Thr Glu Asp Glu His Arg Thr 
         355                360                365
Tyr Leu Asp Val Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ser Lys 
     370                375                380
Arg Leu Gln Val Asn Ile Leu Val Lys Pro Ala Arg Lys Ile Glu Ala 
 385                390                395                400
Leu Lys Asn Leu Lys Arg Pro Tyr Ile Val Pro Ile Leu Trp Leu Asn 
                 405                410                415
Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Glu Met Phe Arg Asn Gln 
             420                425                430
Val Thr Gly Lys Ile Lys Leu Leu Gly Leu Val Glu Met Val Leu Leu 
         435                440                445
Gly Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys Ala 
     450                455                460
Cys Arg Ser Lys Asn Gly Lys 
 465                470



<210> 1064
<211> 1749
<212> DNA
<213> Homo sapiens
<308> BC008406
<400> 1064

gaggactgc  gtgtaggac  ttcctgcag  ataccattt  atcctatta  gaattgtcc  60
aatgttgga  catttgatt  aaaaatcct  cttagccat  ttaaagata  ctttccaat  120
attagacga  ttgattctt  ctgtgactc  tcagttcat  tcctgtaaa  ttcatgtct  180
gctgttgat  tgtgaataa  aaccagagc  tgtagaaac  actttaatc  tatccagga  240
tttgcaaga  acaggtgct  aacactaat  cacctcctg  acaagaaaa  tgggctgtg  300
ccggaactg  gggctcatc  ctggggctg  cattggtgc  gtcctggct  tgtttggag  360
tattctaat  ccagttgga  acctgctta  ccagaagac  attaaaaag  aagttgtcc  420
cgaagaagg  acaattgct  ttaaaaatt  ggttaaaac  ggcacagaa  tttacagac  480
gttttggat  tttgatgtg  aaaatccac  ggaagtgat  atgaacagc  gcaacattc  540
agttaagca  agaggtcct  atacgtaca  agttcgttt  ctagccaag  aaaatgtaa  600
ccaggacgc  gaggacaac  cagtctctt  cctgcagcc  aatggtgcc  tcttcgaac  660
ttcactatc  gttggaaca  aggctgaca  cttcacagt  ctcaatctg  ctgtggcag  720
tgcatccca  atctatcaa  atcaatttg  tcaaatgat  ctcaattca  ttattaaca  780
gtcaaaatc  tctatgttc  aagtcagaa  tttgagaga  ctgttatgg  gctataggg  840
tccattttt  agtttggtt  cataccctg  tactaccac  gttggtctg  tttatcctt  900
caacaatac  gcagatgga  tttataaag  tttcaatgg  aaagataac  taagtaaag  960
tgccataat  gacacatat  aaggtaaaa  gaatctgtc  tattgggaa  gtcactgcg  1020
catgattaa  ggtacagat  cagcctcat  tccaccttt  gttgagaaa  gccaggtat  1080
gcagttctt  tcttctgat  tttgcaggt  aatctatgc  gtatttgaa  ccgacgtta  1140
tctgaaagg  atccctgtg  atagatttg  tcttccatc  aaggccttt  cctctccag  1200
tgaaaaccc  gacaactat  gtttctgca  agaaaaaat  atctcaaaa  attgtacat  1260
atatggtgt  ctagacatc  gcaaatgca  agaagggag  cctgtgtac  tttcacttc  1320
tcattttct  tatgcaagt  ctgatgttt  agaacctat  gatggatta  acccaaatg  1380
agaagaaca  aggacatac  tggatattg  acctataac  ggattcact  tacaatttg  1440
aaaacggct  caggtcaac  tattggtca  gccatcaga  aaaattcaa  tattaaaga  1500
tctgaagag  aactatatt  tgcctattc  ttggcttaa  gagactggg  ccattggtg  1560
tgagaaggc  aacatgttc  gaagtcaag  aactggaaa  ataaacctc  ttggcctga  1620
agaaatgat  ttactcagt  ttggtgtgg  gatgtttgt  gcttttatg  tttcatatt  1680
tgcatgcag  tcgaaaaca  taaaataag  aagtatgta  caaaaaaaa  aaaaaaaaa  1740
aaaaaaaaa  1749



<210> 1065
<211> 471
<212> PRT
<213> Homo sapiens
<308> P16671
<400> 1065

Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly Ala 
  1               5                  10                  15
Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu Leu 
             20                  25                  30
Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr Ile 
         35                  40                  45
Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln Phe 
     50                  55                  60
Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser Ser 
 65                  70                  75                  80
Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg Phe 
                 85                  90                  95
Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val Ser 
             100                105                110
Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val Gly 
         115                120                125
Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala Ala 
     130                135                140
Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser Leu 
 145                150                155                160
Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg Glu 
                 165                170                175
Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr Pro 
             180                185                190
Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala Asp 
         195                200                205
Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val Ala 
     210                215                220
Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu Ser 
 225                230                235                240
His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro Phe 
                 245                250                255
Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys Arg 
             260                265                270
Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile Pro 
         275                280                285
Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val Glu 
     290                295                300
Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys Asn 
 305                310                315                320
Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly Arg 
                 325                330                335
Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp Val 
             340                345                350
Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg Thr 
         355                360                365
Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala Lys 
     370                375                380
Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln Val 
 385                390                395                400
Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu Asn 
                 405                410                415
Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser Gln 
             420                425                430
Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu Leu 
         435                440                445
Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys Ala 
     450                455                460
Cys Arg Ser Lys Thr Ile Lys 
 465                470



<210> 1066
<211> 2971
<212> DNA
<213> Rattus norvegicus
<308> AF072439
<400> 1066

tactcacta  agggctcga  cggccgccc  ggcaggttc  gactccaac  aggacctga  60
aaagccaga  gcggtgggc  ggaggagta  ggacaaagc  aggcgtccg  aggagatgg  120
tacacccga  cctgcagag  gcgatgcgg  atgggagca  ctggaacct  ggcagagaa  180
cttgtacaa  gatacaaag  tagagacct  cagcaatcc  gcctcgatg  gaaatcaag  240
tcccaaaca  ggcctagtc  ctaagttgg  tggagaaga  gagcggtgg  cttcagtga  300
ggcaaataa  aacagctca  gtagtctgc  cagactcaa  aaaacagga  ccagtgcaa  360
ggtccaaca  gatggtgca  agacggagg  gaagcagaa  ttccaaagg  aactcactt  420
agaagtgac  ttcaggaag  aaagttcaa  cagtaagaa  agcagtgag  gtacattgt  480
ggagaagaa  aatgtccat  caaaacatg  tccttctga  aaaagattg  ataaatcca  540
tttgtatgg  aagaacttg  atcagaatt  agacttacc  agtcagatt  aaatctctg  600
gaaaaagaa  cccgataca  ctaatgaat  taggaaatc  ctcagccat  ctgcatccg  660
tgtgaacag  gatgaaatt  caactagaa  gaaatgtga  aagtcaccc  acaataaat  720
gtttggtaa  ggtgacaaa  accaaacag  caagaaatg  gagaaagta  gccgtcata  780
cgcatccca  accaaggaa  acaaaattc  taccgggga  aaacggaaa  caccctgcc  840
tagtccatc  aaatctgac  aggctccag  ctctgggaa  ccttatgaa  gtaatcaat  900
tgggaaggt  ctcagccat  aacaggggc  ccttgacca  caaagaact  atgccgggg  960
agaaccata  gaatgttac  aatgcggga  agctttcag  caaaagtcc  accttgtcg  1020
acatcagaa  actcccact  gggaaaagg  gccatacga  tgtgtccag  gtggcaaag  1080
ccacggtca  aaacatgcc  tcactgacc  cctgagaat  tcccatacc  gagaaaagc  1140
ctacaaatg  aatgaatgt  gcaaaacct  taggcacag  tcaaacctt  tgcaacaca  1200
aagatctca  acgggcgag  agccgtacg  gtgtaagga  tgtggcaaa  ccttcagat  1260
taattcatc  ttcaccgaa  atgtgagaa  acacacagg  gaaataccc  atgaatgta  1320
tgaatgtgg  aaagctttt  agtatggct  atccctgac  aaacacatg  gaattcata  1380
aggcgagaa  ccatttgaa  gtactgagt  tgggaagac  tttagcaaa  agtcacacc  1440
agttataca  cagagaact  acacgaagg  gaaacctta  aaatgtaag  agtgtggca  1500
agcctttgg  catagctca  ctcttactt  tcacatgag  actcacacc  gggattgcc  1560
ttttgaatg  aataaatgt  gcaaggctt  caagcaaat  gagggcctt  ctcaacacc  1620
gagagttca  acaggagag  aaccctatg  gtgtgttga  tgtggaaaa  ccttcagtc  1680
gaagtcaca  ctcatcgta  atcagagaa  tcatacagg  gagaagccc  ttgaatgtt  1740
tgagtgcgg  aaggccttc  atgcaaaat  acaacttgt  attcatcag  gatcccaca  1800
tggagagaa  ccctataaa  cctatgagt  tgttgaatg  ggcaaggcc  tcaaacaaa  1860
tgcttctct  accagacat  tgaagactc  ctcggaaga  caatctcag  aggaagatt  1920
atgtgggaa  tctgacagg  gactggttt  aaatgttta  ccctcaaga  gtatttagt  1980
tgatgatgt  agagtcttt  tttaagagt  tgaatcttt  catgagatc  ttagatggt  2040
ataaagttt  aacttcatc  taaactttc  ttccaggaa  tagtgtgtt  tactgtaca  2100
tggccatat  gataatgat  ggccaggta  tctcaggga  tctcttagc  tcactttcc  2160
agttatgag  ttgcaagat  cacagcagc  aaatcaaaa  cccacccct  ggaaccaca  2220
caaaatcta  atacgacga  gcgctcacg  aacatcata  ctacgaaac  ccagattaa  2280
gaataaaga  gaccacatg  ccaaaatat  gtttaattt  caagccaaa  ggcaaaaca  2340
aaacttcca  aaaaaggga  caggactca  caaaaaggg  actcgtgtt  cacacacac  2400
cacacacac  cacacacac  cacacaaat  tgtgaaaat  ttaattaga  caacaaaca  2460
taaaataca  taattcatg  actttttac  cgtgtgctt  gccaccaca  ttagtattt  2520
ttttgcatt  atgtttact  aaatactag  gcctgtgta  aatacaggc  agggtatcc  2580
ctggtatcg  ctagcttcc  ttgttaatg  cttcgttag  ttctgaagt  ataaaaaat  2640
ttagggagg  cttttgttt  gttttgttt  aacagaatc  taccatatt  gtgctggct  2700
accaagaac  tgttatgtt  aaccatgct  accttgaag  ttttatgtt  aacaggctg  2760
ccttgaact  cccaaaaat  tgcctgtct  tgcctcccc  agttgccta  aattaaaaa  2820
ttccaaaga  aaacttgga  ggaattttt  ctaaaattt  ggtttaaat  aaaaattca  2880
attaaaaat  ttggaaaaa  aactgggca  tgttttttg  taatgaaat  gtactggtt  2940
atatcggtt  aaacttcca  aaatcccaa  a  2971



<210> 1067
<211> 601
<212> PRT
<213> Rattus norvegicus
<308> O88553
<400> 1067

Met Ala Thr Pro Glu Pro Ala Glu Ser Asp Ala Glu Trp Glu Gln Leu 
  1               5                  10                  15
Glu Pro Gly Gln Arg Asn Leu Tyr Lys Asp Thr Lys Leu Glu Thr Cys 
             20                  25                  30
Ser Asn Pro Ala Ser Met Gly Asn Gln Asp Pro Lys Gln Gly Leu Val 
         35                  40                  45
Ser Lys Leu Asp Gly Glu Glu Glu Arg Trp Ser Ser Val Arg Ala Asn 
     50                  55                  60
Lys Asn Ser Ser Ser Ser Leu His Arg Leu Lys Lys Thr Gly Thr Ser 
 65                  70                  75                  80
Ala Lys Val Gln Gln Asp Gly Ala Gln Thr Glu Gly Lys Gln Lys Phe 
                 85                  90                  95
Gln Arg Lys Leu Thr Ser Glu Val Thr Phe Arg Lys Lys Ser Ser Asn 
             100                105                110
Ser Lys Lys Ser Ser Glu Cys Thr Leu Leu Glu Lys Lys Asn Val His 
         115                120                125
Ser Lys His Asp Pro Ser Glu Lys Arg Leu His Lys Ser Asn Leu Tyr 
     130                135                140
Gly Lys Asn Leu Asn Gln Asn Leu Asp Leu Pro Ser Gln Ile Lys Ile 
 145                150                155                160
Ser Ala Lys Lys Lys Pro Asp Thr Ala Asn Glu Tyr Arg Lys Ser Leu 
                 165                170                175
Ser His Ser Ala Ser Asp Val Asn Arg Asp Glu Ile Ser Thr Arg Lys 
             180                185                190
Lys Cys Asp Lys Ser Pro Asn Asn Lys Leu Phe Gly Lys Gly Asp Lys 
         195                200                205
Asn Gln Thr Gly Lys Lys Cys Glu Lys Val Cys Arg His Thr Ala Ser 
     210                215                220
His Thr Lys Glu Asp Lys Ile His Thr Gly Glu Lys Arg Lys Ser Pro 
 225                230                235                240
Cys Arg Ser Pro Ser Lys Ser Asp Lys Ala Pro Gly Ser Gly Lys Pro 
                 245                250                255
Tyr Glu Cys Asn Gln Cys Gly Lys Val Leu Ser His Lys Gln Gly Leu 
             260                265                270
Leu Asp His Gln Arg Thr His Ala Gly Glu Glu Pro Tyr Glu Cys Tyr 
         275                280                285
Glu Cys Gly Ile Ala Phe Ser Gln Lys Ser His Leu Val Val His Gln 
     290                295                300
Lys Thr Pro Thr Gly Glu Lys Ala Pro Tyr Glu Cys Val Gln Cys Gly 
 305                310                315                320
Lys Ala His Gly His Lys His Ala Leu Thr Asp His Leu Arg Ile Ser 
                 325                330                335
His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe 
             340                345                350
Arg His Ser Ser Asn Leu Met Gln His Ile Arg Ser His Thr Gly Glu 
         355                360                365
Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ser Phe Arg Tyr Asn Ser 
     370                375                380
Ser Phe Thr Glu His Val Arg Thr His Thr Gly Glu Ile Pro Tyr Glu 
 385                390                395                400
Cys Asn Glu Cys Gly Lys Ala Phe Lys Tyr Gly Ser Ser Leu Thr Lys 
                 405                410                415
His Met Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys Thr Glu Cys 
             420                425                430
Gly Lys Thr Phe Ser Lys Lys Ser His Leu Val Ile His Gln Arg Thr 
         435                440                445
His Thr Lys Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe 
     450                455                460
Gly His Ser Ser Ser Leu Thr Tyr His Met Arg Thr His Thr Gly Asp 
 465                470                475                480
Cys Pro Phe Glu Cys Asn Lys Cys Gly Lys Ala Phe Lys Gln Ile Glu 
                 485                490                495
Gly Leu Thr Gln His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Glu 
             500                505                510
Cys Val Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser His Leu Ile Val 
         515                520                525
His Gln Arg Thr His Thr Gly Glu Lys Pro Phe Glu Cys Tyr Glu Cys 
     530                535                540
Gly Lys Ala Phe Asn Ala Lys Ser Gln Leu Val Ile His Gln Arg Ser 
 545                550                555                560
His Thr Gly Glu Lys Pro Tyr Lys Pro Tyr Glu Cys Val Glu Cys Gly 
                 565                570                575
Lys Ala Phe Lys Gln Asn Ala Ser Leu Thr Arg His Met Lys Thr His 
             580                585                590
Ser Glu Glu Gln Ser Gln Glu Glu Asp 
         595                600



<210> 1068
<211> 2308
<212> DNA
<213> Homo sapiens
<308> AK000351
<400> 1068

gttttcagg  tcttggcgg  gaaggtcag  gtgcagacc  gagaccact  ctcaccgac  60
tcagactcc  gtttatctg  gccccagct  cctcactta  tctcagaag  cttaggctg  120
ggcctcaga  ggagatctc  atcctttgt  cagagcaga  caggatggc  atgtcccag  180
aatcattga  cttcaagga  gtgtttgtg  acttcaccc  ggaggagtg  cagcaactg  240
actctgccc  gaagaacct  tacagggat  tcatgcttg  gaactacag  cacctggtg  300
ccgtggggt  tctagttgc  aagcctgat  tgatcttca  gttgggacc  ggtggagag  360
cctggatgg  agatggggg  accccggta  ggacctgtg  agaagtctg  caagttgat  420
agcagatag  tcactacaa  gaaagccaa  acaaacttc  ttggcaagc  gcattcata  480
gcaaggaaa  actgaagga  gaaagcggt  aagaatcca  aacatgtag  aaaagcatt  540
atctgagca  agaatttga  tctgtaagg  aaagactcc  taaatatta  tcgtgggaa  600
aggcattca  aacatcatt  aaactttct  ggtcaaaat  gaagctatg  aagaaagaa  660
gatgatgga  gtaaagcat  ttggaaagt  tgcttccat  ataatcttc  taaagctca  720
cctgcagag  gattttttg  ccctaatca  cgagggaaa  ccctccacc  aaagcaagc  780
cttagaaaa  gtcagagaa  tcaaactgg  gagaaactc  acaaatgta  tgaatgtgg  840
aaagtgttt  tccagaaag  aaacttagt  gtacatcaa  gaactcaca  cggagagaa  900
ccttatgaa  gctgcgaat  tgcaaaagc  ttcagccag  agtcaaccc  catagcaca  960
cagagaact  acacagggg  gaagcccta  gaatgcagt  aatgtggaa  aacctttat  1020
cagaagtca  ctctgatta  acataagaa  attcatatg  agagagacc  tataaatgc  1080
gtgtctgtg  gaaagcctt  agtaggaag  caactctca  taaacatca  ataattcat  1140
tgggagaaa  cttatgaat  taataaatg  gggaaatct  ttagtgtta  atcaactct  1200
attgtatgt  acagaacat  aatgcataa  ttgcatgct  ttgtgaata  tgtgatgaa  1260
ttttgcact  tcctgctct  tcctgctca  gatgcaaat  agtgaatct  ttttttttt  1320
tttttttga  acagagtct  gctctgtca  ccaaactgg  gtgcagtgg  acaatcttg  1380
ctcactgca  cctccgcct  ttgggttca  ccgattctc  tgcctcaac  tcccaaata  1440
ttgggatta  aggcacatg  caccatacg  agctaattt  tatttttag  agagacagg  1500
tttcaccat  ttggccagc  tggtcttga  ctcctgacc  caagtgatc  gcctgcctc  1560
gcctcccaa  gtgctggga  tacaggcat  agccactgc  cccggcttg  atcatcctt  1620
tgtccagta  tatatccat  ctgtatatg  tacccgccc  ctagtccct  agctgtctc  1680
gttgtcaga  tgactgtca  gggattgca  tgcttgcat  aaagctacc  ttattgtat  1740
atgacccca  agtgcaaga  tagtgatgt  ggcaatttg  atacaccaa  aataagtta  1800
aaagtgctt  cttaaagtg  aatggttaa  gttcttgac  taataaaga  aaaaaatgt  1860
tgctgaggt  gttaagatt  acagtaaga  tgaatcttc  atccagaaa  tgtgaagga  1920
gaaaaagaa  cttgtgcta  ttttgctgt  acatctgaa  ctgcaaaag  tgtggccac  1980
gtgcatcat  agtgctaag  cgaaaaaga  attaaattt  cggatggaa  gcgtgaata  2040
aaatgggtt  tgacagcaa  caggttcgg  actattcac  gtttcaggc  tccgctagg  2100
atcttggaa  atatccccc  tggataagg  aggggtact  taccttgtc  tattgtgca  2160
taaagaatt  attgagtgt  atcatgtaa  tctaacaca  atttaaaaa  ctctcagat  2220
tcatttcgc  ttcggttga  gtaagaaaa  tcaaagcta  tcaaatcat  caataaatg  2280
taaaattat  taaaaaaaa  aaaaaaaa  2308



<210> 1069
<211> 597
<212> PRT
<213> Homo sapiens
<308> Q9Y6Q3
<400> 1069

Met Ala Val Ser Glu Pro Glu Ala Ser Ala Ala Glu Trp Lys Gln Leu 
  1               5                  10                  15
Asp Pro Ala Gln Ser Asn Leu Tyr Asn Asp Val Met Leu Glu Asn Tyr 
             20                  25                  30
Cys Asn Gln Ala Ser Met Gly Cys Gln Ala Pro Lys Pro Asp Met Ile 
         35                  40                  45
Ser Lys Leu Glu Lys Gly Glu Ala Pro Trp Leu Gly Lys Gly Lys Arg 
     50                  55                  60
Pro Ser Gln Gly Cys Pro Ser Lys Ile Ala Arg Pro Lys Gln Lys Glu 
 65                  70                  75                  80
Thr Asp Gly Lys Val Gln Lys Asp Asp Asp Gln Leu Glu Asn Ile Gln 
                 85                  90                  95
Lys Ser Gln Asn Lys Leu Leu Arg Glu Val Ala Val Lys Lys Lys Thr 
             100                105                110
Gln Ala Lys Lys Asn Gly Ser Asp Cys Gly Ser Leu Gly Lys Lys Asn 
         115                120                125
Asn Leu His Lys Lys His Val Pro Ser Lys Lys Arg Leu Leu Lys Phe 
     130                135                140
Glu Ser Cys Gly Lys Ile Leu Lys Gln Asn Leu Asp Leu Pro Asp His 
 145                150                155                160
Ser Arg Asn Cys Val Lys Arg Lys Ser Asp Ala Ala Lys Glu His Lys 
                 165                170                175
Lys Ser Phe Asn His Ser Leu Ser Asp Thr Arg Lys Gly Lys Lys Gln 
             180                185                190
Thr Gly Lys Lys His Glu Lys Leu Ser Ser His Ser Ser Ser Asp Lys 
         195                200                205
Cys Asn Lys Thr Gly Lys Lys His Asp Lys Leu Cys Cys His Ser Ser 
     210                215                220
Ser His Ile Lys Gln Asp Lys Ile Gln Thr Gly Glu Lys His Glu Lys 
 225                230                235                240
Ser Pro Ser Leu Ser Ser Ser Thr Lys His Glu Lys Pro Gln Ala Cys 
                 245                250                255
Val Lys Pro Tyr Glu Cys Asn Gln Cys Gly Lys Val Leu Ser His Lys 
             260                265                270
Gln Gly Leu Ile Asp His Gln Arg Val His Thr Gly Glu Lys Pro Tyr 
         275                280                285
Glu Cys Asn Glu Cys Gly Ile Ala Phe Ser Gln Lys Ser His Leu Val 
     290                295                300
Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Gln 
 305                310                315                320
Cys Gly Lys Ala His Gly His Lys His Ala Leu Thr Asp His Leu Arg 
                 325                330                335
Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ala Glu Cys Gly Lys Thr 
             340                345                350
Phe Arg His Ser Ser Asn Leu Ile Gln His Val Arg Ser His Thr Gly 
         355                360                365
Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ser Phe Arg Tyr Asn 
     370                375                380
Ser Ser Leu Thr Glu His Val Arg Thr His Thr Gly Glu Ile Pro Tyr 
 385                390                395                400
Glu Cys Asn Glu Cys Gly Lys Ala Phe Lys Tyr Ser Ser Ser Leu Thr 
                 405                410                415
Lys His Met Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys Asn Glu 
             420                425                430
Cys Gly Lys Ala Phe Ser Lys Lys Ser His Leu Ile Ile His Gln Arg 
         435                440                445
Thr His Thr Lys Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala 
     450                455                460
Phe Gly His Ser Ser Ser Leu Thr Tyr His Met Arg Thr His Thr Gly 
 465                470                475                480
Glu Ser Pro Phe Glu Cys Asn Gln Cys Gly Lys Gly Phe Lys Gln Ile 
                 485                490                495
Glu Gly Leu Thr Gln His Gln Arg Val His Thr Gly Glu Lys Pro Tyr 
             500                505                510
Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser His Leu Ile 
         515                520                525
Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu 
     530                535                540
Cys Glu Lys Ala Phe Asn Ala Lys Ser Gln Leu Val Ile His Gln Arg 
 545                550                555                560
Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Thr 
                 565                570                575
Phe Lys Gln Asn Ala Ser Leu Thr Lys His Val Lys Thr His Ser Glu 
             580                585                590
Asp Lys Ser His Glu 
         595



<210> 1070
<211> 2971
<212> DNA
<213> Rattus norvegicus
<308> AF072439
<400> 1070

tactcacta  agggctcga  cggccgccc  ggcaggttc  gactccaac  aggacctga  60
aaagccaga  gcggtgggc  ggaggagta  ggacaaagc  aggcgtccg  aggagatgg  120
tacacccga  cctgcagag  gcgatgcgg  atgggagca  ctggaacct  ggcagagaa  180
cttgtacaa  gatacaaag  tagagacct  cagcaatcc  gcctcgatg  gaaatcaag  240
tcccaaaca  ggcctagtc  ctaagttgg  tggagaaga  gagcggtgg  cttcagtga  300
ggcaaataa  aacagctca  gtagtctgc  cagactcaa  aaaacagga  ccagtgcaa  360
ggtccaaca  gatggtgca  agacggagg  gaagcagaa  ttccaaagg  aactcactt  420
agaagtgac  ttcaggaag  aaagttcaa  cagtaagaa  agcagtgag  gtacattgt  480
ggagaagaa  aatgtccat  caaaacatg  tccttctga  aaaagattg  ataaatcca  540
tttgtatgg  aagaacttg  atcagaatt  agacttacc  agtcagatt  aaatctctg  600
gaaaaagaa  cccgataca  ctaatgaat  taggaaatc  ctcagccat  ctgcatccg  660
tgtgaacag  gatgaaatt  caactagaa  gaaatgtga  aagtcaccc  acaataaat  720
gtttggtaa  ggtgacaaa  accaaacag  caagaaatg  gagaaagta  gccgtcata  780
cgcatccca  accaaggaa  acaaaattc  taccgggga  aaacggaaa  caccctgcc  840
tagtccatc  aaatctgac  aggctccag  ctctgggaa  ccttatgaa  gtaatcaat  900
tgggaaggt  ctcagccat  aacaggggc  ccttgacca  caaagaact  atgccgggg  960
agaaccata  gaatgttac  aatgcggga  agctttcag  caaaagtcc  accttgtcg  1020
acatcagaa  actcccact  gggaaaagg  gccatacga  tgtgtccag  gtggcaaag  1080
ccacggtca  aaacatgcc  tcactgacc  cctgagaat  tcccatacc  gagaaaagc  1140
ctacaaatg  aatgaatgt  gcaaaacct  taggcacag  tcaaacctt  tgcaacaca  1200
aagatctca  acgggcgag  agccgtacg  gtgtaagga  tgtggcaaa  ccttcagat  1260
taattcatc  ttcaccgaa  atgtgagaa  acacacagg  gaaataccc  atgaatgta  1320
tgaatgtgg  aaagctttt  agtatggct  atccctgac  aaacacatg  gaattcata  1380
aggcgagaa  ccatttgaa  gtactgagt  tgggaagac  tttagcaaa  agtcacacc  1440
agttataca  cagagaact  acacgaagg  gaaacctta  aaatgtaag  agtgtggca  1500
agcctttgg  catagctca  ctcttactt  tcacatgag  actcacacc  gggattgcc  1560
ttttgaatg  aataaatgt  gcaaggctt  caagcaaat  gagggcctt  ctcaacacc  1620
gagagttca  acaggagag  aaccctatg  gtgtgttga  tgtggaaaa  ccttcagtc  1680
gaagtcaca  ctcatcgta  atcagagaa  tcatacagg  gagaagccc  ttgaatgtt  1740
tgagtgcgg  aaggccttc  atgcaaaat  acaacttgt  attcatcag  gatcccaca  1800
tggagagaa  ccctataaa  cctatgagt  tgttgaatg  ggcaaggcc  tcaaacaaa  1860
tgcttctct  accagacat  tgaagactc  ctcggaaga  caatctcag  aggaagatt  1920
atgtgggaa  tctgacagg  gactggttt  aaatgttta  ccctcaaga  gtatttagt  1980
tgatgatgt  agagtcttt  tttaagagt  tgaatcttt  catgagatc  ttagatggt  2040
ataaagttt  aacttcatc  taaactttc  ttccaggaa  tagtgtgtt  tactgtaca  2100
tggccatat  gataatgat  ggccaggta  tctcaggga  tctcttagc  tcactttcc  2160
agttatgag  ttgcaagat  cacagcagc  aaatcaaaa  cccacccct  ggaaccaca  2220
caaaatcta  atacgacga  gcgctcacg  aacatcata  ctacgaaac  ccagattaa  2280
gaataaaga  gaccacatg  ccaaaatat  gtttaattt  caagccaaa  ggcaaaaca  2340
aaacttcca  aaaaaggga  caggactca  caaaaaggg  actcgtgtt  cacacacac  2400
cacacacac  cacacacac  cacacaaat  tgtgaaaat  ttaattaga  caacaaaca  2460
taaaataca  taattcatg  actttttac  cgtgtgctt  gccaccaca  ttagtattt  2520
ttttgcatt  atgtttact  aaatactag  gcctgtgta  aatacaggc  agggtatcc  2580
ctggtatcg  ctagcttcc  ttgttaatg  cttcgttag  ttctgaagt  ataaaaaat  2640
ttagggagg  cttttgttt  gttttgttt  aacagaatc  taccatatt  gtgctggct  2700
accaagaac  tgttatgtt  aaccatgct  accttgaag  ttttatgtt  aacaggctg  2760
ccttgaact  cccaaaaat  tgcctgtct  tgcctcccc  agttgccta  aattaaaaa  2820
ttccaaaga  aaacttgga  ggaattttt  ctaaaattt  ggtttaaat  aaaaattca  2880
attaaaaat  ttggaaaaa  aactgggca  tgttttttg  taatgaaat  gtactggtt  2940
atatcggtt  aaacttcca  aaatcccaa  a  2971



<210> 1071
<211> 601
<212> PRT
<213> Rattus norvegicus
<308> O88553
<400> 1071

Met Ala Thr Pro Glu Pro Ala Glu Ser Asp Ala Glu Trp Glu Gln Leu 
  1               5                  10                  15
Glu Pro Gly Gln Arg Asn Leu Tyr Lys Asp Thr Lys Leu Glu Thr Cys 
             20                  25                  30
Ser Asn Pro Ala Ser Met Gly Asn Gln Asp Pro Lys Gln Gly Leu Val 
         35                  40                  45
Ser Lys Leu Asp Gly Glu Glu Glu Arg Trp Ser Ser Val Arg Ala Asn 
     50                  55                  60
Lys Asn Ser Ser Ser Ser Leu His Arg Leu Lys Lys Thr Gly Thr Ser 
 65                  70                  75                  80
Ala Lys Val Gln Gln Asp Gly Ala Gln Thr Glu Gly Lys Gln Lys Phe 
                 85                  90                  95
Gln Arg Lys Leu Thr Ser Glu Val Thr Phe Arg Lys Lys Ser Ser Asn 
             100                105                110
Ser Lys Lys Ser Ser Glu Cys Thr Leu Leu Glu Lys Lys Asn Val His 
         115                120                125
Ser Lys His Asp Pro Ser Glu Lys Arg Leu His Lys Ser Asn Leu Tyr 
     130                135                140
Gly Lys Asn Leu Asn Gln Asn Leu Asp Leu Pro Ser Gln Ile Lys Ile 
 145                150                155                160
Ser Ala Lys Lys Lys Pro Asp Thr Ala Asn Glu Tyr Arg Lys Ser Leu 
                 165                170                175
Ser His Ser Ala Ser Asp Val Asn Arg Asp Glu Ile Ser Thr Arg Lys 
             180                185                190
Lys Cys Asp Lys Ser Pro Asn Asn Lys Leu Phe Gly Lys Gly Asp Lys 
         195                200                205
Asn Gln Thr Gly Lys Lys Cys Glu Lys Val Cys Arg His Thr Ala Ser 
     210                215                220
His Thr Lys Glu Asp Lys Ile His Thr Gly Glu Lys Arg Lys Ser Pro 
 225                230                235                240
Cys Arg Ser Pro Ser Lys Ser Asp Lys Ala Pro Gly Ser Gly Lys Pro 
                 245                250                255
Tyr Glu Cys Asn Gln Cys Gly Lys Val Leu Ser His Lys Gln Gly Leu 
             260                265                270
Leu Asp His Gln Arg Thr His Ala Gly Glu Glu Pro Tyr Glu Cys Tyr 
         275                280                285
Glu Cys Gly Ile Ala Phe Ser Gln Lys Ser His Leu Val Val His Gln 
     290                295                300
Lys Thr Pro Thr Gly Glu Lys Ala Pro Tyr Glu Cys Val Gln Cys Gly 
 305                310                315                320
Lys Ala His Gly His Lys His Ala Leu Thr Asp His Leu Arg Ile Ser 
                 325                330                335
His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe 
             340                345                350
Arg His Ser Ser Asn Leu Met Gln His Ile Arg Ser His Thr Gly Glu 
         355                360                365
Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ser Phe Arg Tyr Asn Ser 
     370                375                380
Ser Phe Thr Glu His Val Arg Thr His Thr Gly Glu Ile Pro Tyr Glu 
 385                390                395                400
Cys Asn Glu Cys Gly Lys Ala Phe Lys Tyr Gly Ser Ser Leu Thr Lys 
                 405                410                415
His Met Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys Thr Glu Cys 
             420                425                430
Gly Lys Thr Phe Ser Lys Lys Ser His Leu Val Ile His Gln Arg Thr 
         435                440                445
His Thr Lys Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe 
     450                455                460
Gly His Ser Ser Ser Leu Thr Tyr His Met Arg Thr His Thr Gly Asp 
 465                470                475                480
Cys Pro Phe Glu Cys Asn Lys Cys Gly Lys Ala Phe Lys Gln Ile Glu 
                 485                490                495
Gly Leu Thr Gln His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Glu 
             500                505                510
Cys Val Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser His Leu Ile Val 
         515                520                525
His Gln Arg Thr His Thr Gly Glu Lys Pro Phe Glu Cys Tyr Glu Cys 
     530                535                540
Gly Lys Ala Phe Asn Ala Lys Ser Gln Leu Val Ile His Gln Arg Ser 
 545                550                555                560
His Thr Gly Glu Lys Pro Tyr Lys Pro Tyr Glu Cys Val Glu Cys Gly 
                 565                570                575
Lys Ala Phe Lys Gln Asn Ala Ser Leu Thr Arg His Met Lys Thr His 
             580                585                590
Ser Glu Glu Gln Ser Gln Glu Glu Asp 
         595                600



<210> 1072
<211> 2308
<212> DNA
<213> Homo sapiens
<308> AK000351
<400> 1072

gttttcagg  tcttggcgg  gaaggtcag  gtgcagacc  gagaccact  ctcaccgac  60
tcagactcc  gtttatctg  gccccagct  cctcactta  tctcagaag  cttaggctg  120
ggcctcaga  ggagatctc  atcctttgt  cagagcaga  caggatggc  atgtcccag  180
aatcattga  cttcaagga  gtgtttgtg  acttcaccc  ggaggagtg  cagcaactg  240
actctgccc  gaagaacct  tacagggat  tcatgcttg  gaactacag  cacctggtg  300
ccgtggggt  tctagttgc  aagcctgat  tgatcttca  gttgggacc  ggtggagag  360
cctggatgg  agatggggg  accccggta  ggacctgtg  agaagtctg  caagttgat  420
agcagatag  tcactacaa  gaaagccaa  acaaacttc  ttggcaagc  gcattcata  480
gcaaggaaa  actgaagga  gaaagcggt  aagaatcca  aacatgtag  aaaagcatt  540
atctgagca  agaatttga  tctgtaagg  aaagactcc  taaatatta  tcgtgggaa  600
aggcattca  aacatcatt  aaactttct  ggtcaaaat  gaagctatg  aagaaagaa  660
gatgatgga  gtaaagcat  ttggaaagt  tgcttccat  ataatcttc  taaagctca  720
cctgcagag  gattttttg  ccctaatca  cgagggaaa  ccctccacc  aaagcaagc  780
cttagaaaa  gtcagagaa  tcaaactgg  gagaaactc  acaaatgta  tgaatgtgg  840
aaagtgttt  tccagaaag  aaacttagt  gtacatcaa  gaactcaca  cggagagaa  900
ccttatgaa  gctgcgaat  tgcaaaagc  ttcagccag  agtcaaccc  catagcaca  960
cagagaact  acacagggg  gaagcccta  gaatgcagt  aatgtggaa  aacctttat  1020
cagaagtca  ctctgatta  acataagaa  attcatatg  agagagacc  tataaatgc  1080
gtgtctgtg  gaaagcctt  agtaggaag  caactctca  taaacatca  ataattcat  1140
tgggagaaa  cttatgaat  taataaatg  gggaaatct  ttagtgtta  atcaactct  1200
attgtatgt  acagaacat  aatgcataa  ttgcatgct  ttgtgaata  tgtgatgaa  1260
ttttgcact  tcctgctct  tcctgctca  gatgcaaat  agtgaatct  ttttttttt  1320
tttttttga  acagagtct  gctctgtca  ccaaactgg  gtgcagtgg  acaatcttg  1380
ctcactgca  cctccgcct  ttgggttca  ccgattctc  tgcctcaac  tcccaaata  1440
ttgggatta  aggcacatg  caccatacg  agctaattt  tatttttag  agagacagg  1500
tttcaccat  ttggccagc  tggtcttga  ctcctgacc  caagtgatc  gcctgcctc  1560
gcctcccaa  gtgctggga  tacaggcat  agccactgc  cccggcttg  atcatcctt  1620
tgtccagta  tatatccat  ctgtatatg  tacccgccc  ctagtccct  agctgtctc  1680
gttgtcaga  tgactgtca  gggattgca  tgcttgcat  aaagctacc  ttattgtat  1740
atgacccca  agtgcaaga  tagtgatgt  ggcaatttg  atacaccaa  aataagtta  1800
aaagtgctt  cttaaagtg  aatggttaa  gttcttgac  taataaaga  aaaaaatgt  1860
tgctgaggt  gttaagatt  acagtaaga  tgaatcttc  atccagaaa  tgtgaagga  1920
gaaaaagaa  cttgtgcta  ttttgctgt  acatctgaa  ctgcaaaag  tgtggccac  1980
gtgcatcat  agtgctaag  cgaaaaaga  attaaattt  cggatggaa  gcgtgaata  2040
aaatgggtt  tgacagcaa  caggttcgg  actattcac  gtttcaggc  tccgctagg  2100
atcttggaa  atatccccc  tggataagg  aggggtact  taccttgtc  tattgtgca  2160
taaagaatt  attgagtgt  atcatgtaa  tctaacaca  atttaaaaa  ctctcagat  2220
tcatttcgc  ttcggttga  gtaagaaaa  tcaaagcta  tcaaatcat  caataaatg  2280
taaaattat  taaaaaaaa  aaaaaaaa  2308



<210> 1073
<211> 597
<212> PRT
<213> Homo sapiens
<308> Q9Y6Q3
<400> 1073

Met Ala Val Ser Glu Pro Glu Ala Ser Ala Ala Glu Trp Lys Gln Leu 
  1               5                  10                  15
Asp Pro Ala Gln Ser Asn Leu Tyr Asn Asp Val Met Leu Glu Asn Tyr 
             20                  25                  30
Cys Asn Gln Ala Ser Met Gly Cys Gln Ala Pro Lys Pro Asp Met Ile 
         35                  40                  45
Ser Lys Leu Glu Lys Gly Glu Ala Pro Trp Leu Gly Lys Gly Lys Arg 
     50                  55                  60
Pro Ser Gln Gly Cys Pro Ser Lys Ile Ala Arg Pro Lys Gln Lys Glu 
 65                  70                  75                  80
Thr Asp Gly Lys Val Gln Lys Asp Asp Asp Gln Leu Glu Asn Ile Gln 
                 85                  90                  95
Lys Ser Gln Asn Lys Leu Leu Arg Glu Val Ala Val Lys Lys Lys Thr 
             100                105                110
Gln Ala Lys Lys Asn Gly Ser Asp Cys Gly Ser Leu Gly Lys Lys Asn 
         115                120                125
Asn Leu His Lys Lys His Val Pro Ser Lys Lys Arg Leu Leu Lys Phe 
     130                135                140
Glu Ser Cys Gly Lys Ile Leu Lys Gln Asn Leu Asp Leu Pro Asp His 
 145                150                155                160
Ser Arg Asn Cys Val Lys Arg Lys Ser Asp Ala Ala Lys Glu His Lys 
                 165                170                175
Lys Ser Phe Asn His Ser Leu Ser Asp Thr Arg Lys Gly Lys Lys Gln 
             180                185                190
Thr Gly Lys Lys His Glu Lys Leu Ser Ser His Ser Ser Ser Asp Lys 
         195                200                205
Cys Asn Lys Thr Gly Lys Lys His Asp Lys Leu Cys Cys His Ser Ser 
     210                215                220
Ser His Ile Lys Gln Asp Lys Ile Gln Thr Gly Glu Lys His Glu Lys 
 225                230                235                240
Ser Pro Ser Leu Ser Ser Ser Thr Lys His Glu Lys Pro Gln Ala Cys 
                 245                250                255
Val Lys Pro Tyr Glu Cys Asn Gln Cys Gly Lys Val Leu Ser His Lys 
             260                265                270
Gln Gly Leu Ile Asp His Gln Arg Val His Thr Gly Glu Lys Pro Tyr 
         275                280                285
Glu Cys Asn Glu Cys Gly Ile Ala Phe Ser Gln Lys Ser His Leu Val 
     290                295                300
Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Gln 
 305                310                315                320
Cys Gly Lys Ala His Gly His Lys His Ala Leu Thr Asp His Leu Arg 
                 325                330                335
Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ala Glu Cys Gly Lys Thr 
             340                345                350
Phe Arg His Ser Ser Asn Leu Ile Gln His Val Arg Ser His Thr Gly 
         355                360                365
Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ser Phe Arg Tyr Asn 
     370                375                380
Ser Ser Leu Thr Glu His Val Arg Thr His Thr Gly Glu Ile Pro Tyr 
 385                390                395                400
Glu Cys Asn Glu Cys Gly Lys Ala Phe Lys Tyr Ser Ser Ser Leu Thr 
                 405                410                415
Lys His Met Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys Asn Glu 
             420                425                430
Cys Gly Lys Ala Phe Ser Lys Lys Ser His Leu Ile Ile His Gln Arg 
         435                440                445
Thr His Thr Lys Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala 
     450                455                460
Phe Gly His Ser Ser Ser Leu Thr Tyr His Met Arg Thr His Thr Gly 
 465                470                475                480
Glu Ser Pro Phe Glu Cys Asn Gln Cys Gly Lys Gly Phe Lys Gln Ile 
                 485                490                495
Glu Gly Leu Thr Gln His Gln Arg Val His Thr Gly Glu Lys Pro Tyr 
             500                505                510
Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser His Leu Ile 
         515                520                525
Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu 
     530                535                540
Cys Glu Lys Ala Phe Asn Ala Lys Ser Gln Leu Val Ile His Gln Arg 
 545                550                555                560
Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Thr 
                 565                570                575
Phe Lys Gln Asn Ala Ser Leu Thr Lys His Val Lys Thr His Ser Glu 
             580                585                590
Asp Lys Ser His Glu 
         595



<210> 1074
<211> 4527
<212> DNA
<213> Rattus norvegicus
<308> AF074609
<400> 1074

ggttcgaca  atcttagtc  gcttccatg  gatcagtgg  gggctggga  tccccatct  60
ctcctagtt  cacttctgc  cctaacctg  tgattcctt  tgcctggat  acgccttgg  120
aaatctcac  cccatttgt  tgctgcgat  cttgtgaac  aatcagctt  gcctcagac  180
gtggttata  agttcacgc  gccctggag  ctcagaagc  tctggaatc  cagatggca  240
aggtggcgc  ccccacgct  cccctgctg  tggcggcca  cctggcccc  acccagacc  300
gcgcgggtg  gtgcgggat  aggagggaa  aggcctctg  ggggcaggg  ggggtcggc  360
ttggagaag  cgggtcccc  ggtcgcaca  cagaccctc  gtcccttct  cacctggga  420
tcgaacact  cgccctgct  cccaaccgg  ccgcgcatc  gcccgggtt  ccagaagga  480
gtcggggtc  caccgcgcg  cgcccctag  ctcacactc  ctgcggtat  tctacaccg  540
tgtgtcccg  cccggcctt  gggagcccc  tttcattgc  gtcggctac  tggacgaca  600
gccgttcgt  cgctacgac  gcgatgcgg  gaatccgag  atggagccg  gggtgacgt  660
gatggagcg  gaggggccg  agtattggg  ggaggagac  cggagaatc  aggaaaccg  720
gcagtggtt  caaatggac  tgaggaccc  gcgcggcta  tacaaccag  acgaggacg  780
tgagtgacc  cgggtcggg  gtcaagacc  ctccgcgtt  ccacaccac  tgcggagac  840
tccctagtc  ctagtccga  gttcaggag  tgaacctac  gggtccggt  tacctgggt  900
ggtgggcgg  gctgaccgc  aggtcctca  gctctcaca  catccagag  atctttggc  960
gtgacttgg  atcggacgg  aaactccgc  gcgggtatg  tcagctcgc  tatgatggc  1020
tcgatcaca  cgcccttaa  gaagacctg  aaaagtgga  ggtggcaga  aaggtggca  1080
ggattaccc  aagcaggtt  gagcagact  gtgaaacag  gagacgaag  gcctacctg  1140
agggtgaat  cgtggagtc  ctccacaga  acctggagc  tgggaagga  cgctctgcg  1200
cgtcaggtg  gggggccgc  ggcttctcc  cctcctgcc  tcgggctgg  gctcagtcc  1260
ggggaagaa  aaaccctca  ctgggtatg  ccctgtctc  gagggggag  cagtgtccc  1320
gggtctcct  atctctcat  acagtgact  cactgcctc  cccagggcc  agcttctcc  1380
tggagagtt  tgagtccct  tcaggaagg  aggagagaa  ttcctgtct  aacagcagg  1440
gctccctgc  atcagccat  gcctctccc  ggccaggtt  tctgcccac  cccactctc  1500
gaggacact  actcctgtc  tgctgagtg  gtcagccct  acacctgag  accagaagt  1560
tcctttacc  cataggaga  atggactcc  ctacactag  ctggttctc  cgagtttcc  1620
gaactttcc  tagaataca  tctcacaga  ccctccctg  tgtggggtt  gcttctctt  1680
cacacccca  ttctctcta  tcctacagt  gagaatggt  ccatgagcc  ttatggggt  1740
ccccagagg  acataaatt  tgggatttc  ctttgtttt  tcttttttt  ctctctttt  1800
cttcttact  tcttttttc  ttccttttt  tttttgaag  gattatttt  cttctagtc  1860
ggttttctc  gcaaacaca  attaaacca  ttattttcc  ttccctctt  cgttctatg  1920
ccacccatc  catgctata  aacatcaca  aaggacggc  atgttgacc  actggctca  1980
gtggattcc  tcttagctt  tgagtccct  aggaaagtg  gcagttctg  gctgagggc  2040
ccagctctc  ctgcagctc  ctagttgat  acagttgaa  tgtcagaca  acacagttc  2100
gtgtcatcc  tgatttaac  gtgtcttgt  tagatttca  tttgtcttg  taactgtgt  2160
atttcttaa  tcttccaca  agatcccct  aaggtgcat  tgactcttc  ccccagacc  2220
gaaggtggt  tcaccctga  gtgctgggc  ctgggcttc  accctgctg  aatcaccct  2280
tcctggcag  tgaatgggg  ggacctgac  caggacgtg  agattgtgg  gaccaggcc  2340
gcaggggat  gaaccttcc  gaagtgggc  tctgtggtg  tgcctcctg  gaaggagca  2400
aagtacaca  gccatgtgg  tcatgaggg  ctgcctgag  cgattaccc  gagatgggg  2460
aaggatgga  ccttctgta  accctgagc  ggtcagggc  gagaggtgg  gtcatgacc  2520
ccaccttca  ttcttgaac  tgtacttcc  agagccttc  ccatccacc  actccaaca  2580
ggaaaccta  gtcatttat  tcgtccttg  agctgtggc  atcattgca  ctgtgatca  2640
tggagctgt  gtggctgtt  tgaggaaga  gaggagaaa  acaggtagg  aagagcagg  2700
tctgtttcc  ctcagcttc  tttagaaga  cgctctgct  attaatggg  aacatggcc  2760
cacccctca  tgctgctgt  tccaactag  tcctctgtc  gttctggaa  cttcctcct  2820
tcaagatct  ccttgaact  tcacagctt  tcttctcac  ggaggaaca  gaggagact  2880
cacccctgc  ccaggttag  gtgggggca  gagtgtccc  gaggttatt  gagtgaagc  2940
ggagatgct  ggagctctg  gaatccata  tagctcctc  agagaaatc  tctgggggt  3000
tcagttgta  catgatatg  atctataca  acacataca  atacatttt  catatatac  3060
tatacatat  ttttgtttt  ccctaggca  ggacagctc  tagagctct  atgtgtccc  3120
cccagattg  aaaggtgac  ctgggtctg  ctggggagg  ataatgtgg  catgattgg  3180
tttcaggga  tcccagaat  ccctgtgag  ggagggttg  tgggctgtt  tcttcacag  3240
gatggtttg  gactctcgt  ctccagcat  aagacagct  cctggagtg  actgagtga  3300
agacgatgt  ttcaggtct  tcctgtgac  tccagagcc  tcagttctc  ttagacacc  3360
gtgtctgaa  ttccctgtg  ttctatggc  tcagtgtga  gaactgtgg  gcccagcct  3420
ccctgcaca  caggaccct  tccctgcac  gcctgtgtt  ccctccaca  tcagccttg  3480
tggtccagc  tagggttca  gggtgggga  atctgcatc  tgtccccct  tgccaccct  3540
agcttcagc  cctcactcc  cactgagaa  aagaatctg  gtgtgaact  gattgtcca  3600
atccttgac  cagtgtgga  ggcttttta  attactgga  ggaatattt  gtggttttt  3660
gttttgggg  tttgctttg  ttcgttttg  ttttgaaaa  ataaatgga  gatggagaa  3720
cttccagaa  ctgtgtcac  aagctgtgt  tctggtggg  cagggtgag  tggtgggag  3780
tgagtgtgg  cagggctgt  cccaggtgt  ctcagtcag  tcttgtctt  gatgggctc  3840
ggcctcagc  ctgtcacct  caggctgtg  cctctccat  actgtgaag  catggggag  3900
gtctgtgat  acaaggaca  agggaaggc  agagccttg  cctgacccc  ggattatga  3960
ccccccagg  ctgaagatc  gagactcaa  tggggtcct  taaagtgca  ggtgcacaa  4020
atgagtcca  tacatttcc  cccacccac  taatttagc  gctaatgat  tggtcggga  4080
gctgccctg  tctctccct  tggccatgc  gctgtggtg  tttctgctt  tcctctccc  4140
gtgcaggga  ctgccggta  aggaagtgc  tttttgttg  actttcaga  gcacatcca  4200
agctggaga  aactggatt  gacttttca  aacctattt  cagtaatgg  tttcttaaa  4260
atgtaacct  ccttctcat  caaacccca  caaaggaca  ggaaaagaa  tgttatgag  4320
atactggag  ggtgggctt  tttagaaat  gttctctgg  gcaaattaa  ctgcagctc  4380
gttcacaag  atcagcaat  gctggtcag  tcagaagaa  ctgggaggc  gagctgttt  4440
ctgtgtagt  gttcctggg  tcaactcca  tctctaatt  acagtacag  agccgtcca  4500
gtccgtagt  tcaggatgg  agacacg  4527



<210> 1075
<211> 363
<212> PRT
<213> Rattus norvegicus
<308> AAC33332
<400> 1075

Met Ala Glu Val Ala His Pro Thr Leu Pro Leu Leu Leu Ala Ala Thr 
  1               5                  10                  15
Leu Ala Pro Thr Gln Thr Arg Ala Gly Ser His Ser Leu Arg Tyr Phe 
             20                  25                  30
Tyr Thr Ala Val Ser Arg Pro Gly Leu Gly Glu Pro Leu Phe Ile Ala 
         35                  40                  45
Val Gly Tyr Val Asp Asp Thr Pro Phe Val Arg Tyr Asp Ser Asp Ala 
     50                  55                  60
Glu Asn Pro Arg Met Glu Pro Arg Val Thr Trp Met Glu Arg Glu Gly 
 65                  70                  75                  80
Pro Glu Tyr Trp Glu Glu Glu Thr Arg Arg Ile Gln Glu Thr Glu Gln 
                 85                  90                  95
Trp Phe Gln Met Asp Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Asn 
             100                105                110
Glu Asp Gly Ser His Thr Ile Gln Arg Ile Phe Gly Cys Asp Leu Gly 
         115                120                125
Ser Asp Gly Lys Leu Arg Arg Gly Tyr Asp Gln Leu Ala Tyr Asp Gly 
     130                135                140
Leu Asp His Ile Ala Leu Lys Glu Asp Leu Lys Lys Trp Thr Val Ala 
 145                150                155                160
Asp Lys Val Ala Trp Ile Thr Arg Ser Arg Leu Glu Gln Thr Gly Glu 
                 165                170                175
Thr Glu Arg Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Ser Leu 
             180                185                190
His Arg Tyr Leu Glu Leu Gly Lys Glu Arg Ser Ala Ala Ser Asp Pro 
         195                200                205
Leu Lys Val His Val Thr Leu His Pro Arg Pro Glu Gly Gly Val Thr 
     210                215                220
Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Ser 
 225                230                235                240
Trp Gln Leu Asn Gly Glu Asp Leu Thr Gln Asp Val Glu Ile Val Glu 
                 245                250                255
Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val 
             260                265                270
Val Pro Pro Gly Lys Glu Gln Lys Tyr Thr Cys His Val Asp His Glu 
         275                280                285
Gly Leu Pro Glu Pro Ile Thr Gln Arg Trp Glu Pro Ser Pro Ser Thr 
     290                295                300
Asp Ser Asn Met Glu Thr Tyr Val Ile Tyr Val Val Leu Gly Ala Val 
 305                310                315                320
Ala Ile Ile Ala Ala Val Ile Ile Gly Ala Val Val Ala Val Val Arg 
                 325                330                335
Lys Arg Arg Arg Asn Thr Ala Phe Leu Leu Thr Gly Gly Thr Gly Gly 
             340                345                350
Asp Tyr Thr Pro Ala Pro Gly Arg Asp Ser Ser 
         355                360



<210> 1076
<211> 4198
<212> DNA
<213> Rattus norvegicus
<308> AF076183
<400> 1076

gacgcgctg  gccgctgcc  ccgcggggg  gaagcctgc  agtagctcg  gtgcccgca  60
tccgcgtaa  ccccgcgcc  cttccaccc  tggccaggc  atggcggaa  gtggagggg  120
gggcggtgg  cccggaggc  ccgggggcg  cagcagtca  cggggctct  gggttgccc  180
gtccccgca  cagcagccg  cgcagcagc  atctcagcc  caacagcca  cgcccccca  240
actggccca  gccacctcg  cctcctcgt  cacctcggc  gcggccgcc  cctcctcgt  300
ctcctccac  tccacctcc  tggccgtcg  ggtggcctc  ggctctgcg  ctcccggcg  360
tccgggacc  ggccgcacc  ccgccccag  gcagatgaa  ttgtatgct  cctgggagg  420
ggaccggag  tcatccagc  gcgtgccca  actcttcag  ttgactctg  agaaacttg  480
tatgcttaa  gaaatggac  aagatctta  ctcagtagt  attgctgtg  agctgcagg  540
ttcaaaaag  attcttcgc  ctaatgaga  catccttcc  gccagtggc  tggtggaaa  600
agagctcca  ttaaccttc  ccctccagt  ccctcattt  cttaagcga  atgccaaca  660
actgcagat  atgttgcaa  ggaggaagc  gtacaagaa  cggactatc  tgggctata  720
aaccttggc  gtgggactc  tcaacatgg  agaggtgat  caacaccct  acgagggtg  780
tttagtact  ggcctgcat  gcaacgtaa  ggatgtctc  gtgcctgtg  cagaaataa  840
aatctactc  ttatccagc  agcccattg  ccatgaagg  atcaagtct  agctgtctg  900
tcgctcccc  gatattgac  actactctg  agaagagga  gaaagcttc  cctcagagc  960
ggaaggcag  gatgaccca  tacatggac  ggacctatt  tatgaagat  aagatcttc  1020
gaaagtaaa  aagactcga  ggaaactga  ctcaacctc  gccatcact  ggcaaccga  1080
catcaaaca  aagtttgtg  ccctcctga  acgattcaa  gtttctgat  aggtgggct  1140
tgggctaga  catgtgtca  gggagcaga  tcgggaagt  gaagaggac  tggatgaac  1200
atacgacag  ctagaaatg  acaacccca  cgacagtgg  cctgagatg  aagaaacag  1260
aagcatcct  agcacccca  agcccaagc  caagccctt  tttgagggg  tgtctcagt  1320
cagctcaca  acggagatc  gcagtctca  cagcaaggg  agccttgga  aagacacca  1380
cagccctat  gaattggca  ctttagaaa  agttaagtc  acttggatt  aaaaccaag  1440
tgacagctt  actgaaaca  acactttag  aatcactga  caggacatg  ttggagatg  1500
gagcacaag  ctggttgta  cagaaaaag  caaaactcc  atgaagtcc  gcaaagctg  1560
tctgcaggg  tccgcctcg  cgagcaagg  ggaagggac  cacacacct  gccaaaaga  1620
gagcactcc  ctgaaggag  ggcagctct  caagcccct  agtgagagg  ccaacagct  1680
tgacagtga  cgctctcct  acctagggc  cagcacaca  attccacga  aggtggtat  1740
cgatcaact  aatcagatc  tggtttccg  tgcagcgct  cctgagaat  tcatcctgg  1800
gaacaccac  gactggcag  gccagtatg  ggccgaatt  cttcaagac  agaggaagc  1860
tgttgtgtg  acctgctca  cagtggagg  ccaggccgt  ttgtctgcc  tgctcacta  1920
gattcagcg  tactgcaac  gcaactcat  tatgccgag  ccagtcaag  tggcagctg  1980
gggcagcca  agttacctg  gctccatcc  tcggttttt  gtcaagtcc  ttgccagca  2040
gaccccgga  tggctgggc  acatgcgct  cctcatcgt  cccctaggt  ctcatccag  2100
ggccaaata  ttgggctca  tagatagta  atatagcag  acctttctt  attctgctt  2160
gagagacct  ttcagtcgc  cagagcctc  agtgtcaga  ccactggat  tggtgggtc  2220
tgtgatgca  tatgtcaat  gagctacca  aacgcacca  ctgcctgtg  ctgaagcca  2280
gttgacctg  aggcataag  tccctgatg  agactccta  cagaagttt  tccccttca  2340
tggtgttgt  aaagtgggc  ttgttgaag  ctcgccctc  actgcaggt  atggggacg  2400
ttcacctgt  gtcagcctt  ctgtgccct  cacatcacc  ccctcaagc  cgggcctga  2460
ccgagatgc  acagctacc  ctccctcat  cccatccat  agcagtgcc  tcgccatcg  2520
ggggagccc  aatagccct  atggggatg  gattggcct  caggtggat  actggctgg  2580
ccaccctgg  gagcgaagg  gagaaggtg  taagaggga  gccagttca  agaataccc  2640
caagagtgt  ttccgctca  tgcaggttt  tcgcctgcc  catgcaggg  aagcccagc  2700
ttctggcac  atggcaatg  ctgtggtca  caaagagaa  aacaagaaa  tgcccacta  2760
cttcctgag  aagaagccc  gggaaaagg  ggtggattc  aagagccaa  tcatcgagg  2820
catcagccg  ctcatctgt  ctgcaaagc  gcagcaaac  atgctgaga  tgtccattg  2880
tggagttga  tggagtgac  tcaagttct  ccagctggc  gctcagtgg  ccactcatg  2940
caagcactt  ccagtggga  tcttcagtg  cagcaaacc  acctgagac  tgcctccca  3000
ccactccct  ctggcactg  cacccagcc  agcctcctt  cctagcact  gggcttgcc  3060
ccacttgcc  agtcctgaa  gacactgcc  ctggggatg  agtcctccc  gctcactgc  3120
cagccatct  tgcccagct  ccccctgtt  caggcccag  gctgggtga  cctgccttc  3180
ggtgcccat  attcctgta  ttgaataat  tgggccttc  ttcacctca  ccctgcagc  3240
ctggtaccc  ttctagaaa  gaaacacct  gagttctgg  acacaggga  acagcccag  3300
atcctacat  agctggcca  ccagctctg  atttctaag  ctctgttgc  tgttgtact  3360
accctgcct  cctccagca  ggctggggc  tcctgccat  cctcacctg  ctcacagtt  3420
cccagtagg  ggaaggagg  tggcacctg  gcatcctgg  gtttctggg  ttgaaggga  3480
cttcccagt  tcccatgca  gatttcctg  cacttcaag  cgcttggat  tcctgtgtt  3540
tgtgtgttt  tagttgttt  ggtaacttg  cctgtgcac  ggtccttaa  gctccttct  3600
cctctgcct  ccagcctcc  acctaacat  gctctgtgg  ttcatgagg  aggagacag  3660
aaacccacc  acccaccca  cccttcacc  ctcaacaca  acatcatct  tggctctca  3720
ccagtcata  tgtccccct  tcctgtgtc  gcttgcctc  tggctctgc  ctgtcatcc  3780
acttccttc  tggcagggc  gcagaatga  gcccttctc  accaggtct  cctccagca  3840
cctccttcc  tctctcagc  atgaatggg  cccagacct  cctcagcct  cttatcagt  3900
tcttcatga  aggctgagg  caagggaca  atctggccc  gcctccatg  cctctgtgt  3960
ctatggcac  tcagagctt  tccgttgcc  ctcagtgtt  cctagcagt  tggcacgga  4020
ctgcacttg  aacctagtt  tggtgttct  cacatccaa  actcttaag  ccctcccgc  4080
gcccagcct  tccagagta  ctcctgggc  tgagaataa  tggggtggg  agactgggg  4140
catgttggg  tttttcatt  aataaactg  tgatttctt  ccaaaaaaa  aaaaaaaa  4198



<210> 1077
<211> 961
<212> PRT
<213> Rattus norvegicus
<308> AAC31815
<400> 1077

Met Ala Glu Arg Gly Gly Ala Gly Gly Gly Pro Gly Gly Ala Gly Gly 
  1               5                  10                  15
Gly Ser Ser Gln Arg Gly Ser Gly Val Ala Gln Ser Pro Gln Gln Gln 
             20                  25                  30
Pro Pro Gln Gln Pro Ser Gln Pro Gln Gln Pro Thr Pro Pro Lys Leu 
         35                  40                  45
Ala Gln Ala Thr Ser Ser Ser Ser Ser Thr Ser Ala Ala Ala Ala Ser 
     50                  55                  60
Ser Ser Ser Ser Ser Thr Ser Thr Ser Met Ala Val Ala Val Ala Ser 
 65                  70                  75                  80
Gly Ser Ala Pro Pro Gly Gly Pro Gly Pro Gly Arg Thr Pro Ala Pro 
                 85                  90                  95
Val Gln Met Asn Leu Tyr Ala Thr Trp Glu Val Asp Arg Ser Ser Ser 
             100                105                110
Ser Cys Val Pro Arg Leu Phe Ser Leu Thr Leu Lys Lys Leu Val Met 
         115                120                125
Leu Lys Glu Met Asp Lys Asp Leu Asn Ser Val Val Ile Ala Val Lys 
     130                135                140
Leu Gln Gly Ser Lys Arg Ile Leu Arg Ser Asn Glu Ile Ile Leu Pro 
 145                150                155                160
Ala Ser Gly Leu Val Glu Thr Glu Leu Gln Leu Thr Phe Ser Leu Gln 
                 165                170                175
Tyr Pro His Phe Leu Lys Arg Asp Ala Asn Lys Leu Gln Ile Met Leu 
             180                185                190
Gln Arg Arg Lys Arg Tyr Lys Asn Arg Thr Ile Leu Gly Tyr Lys Thr 
         195                200                205
Leu Ala Val Gly Leu Ile Asn Met Ala Glu Val Met Gln His Pro Asn 
     210                215                220
Glu Gly Ala Leu Val Leu Gly Leu His Ser Asn Val Lys Asp Val Ser 
 225                230                235                240
Val Pro Val Ala Glu Ile Lys Ile Tyr Ser Leu Ser Ser Gln Pro Ile 
                 245                250                255
Asp His Glu Gly Ile Lys Ser Lys Leu Ser Asp Arg Ser Pro Asp Ile 
             260                265                270
Asp Asn Tyr Ser Glu Glu Glu Glu Glu Ser Phe Ser Ser Glu Gln Glu 
         275                280                285
Gly Ser Asp Asp Pro Leu His Gly Gln Asp Leu Phe Tyr Glu Asp Glu 
     290                295                300
Asp Leu Arg Lys Val Lys Lys Thr Arg Arg Lys Leu Thr Ser Thr Ser 
 305                310                315                320
Ala Ile Thr Arg Gln Pro Asn Ile Lys Gln Lys Phe Val Ala Leu Leu 
                 325                330                335
Lys Arg Phe Lys Val Ser Asp Glu Val Gly Phe Gly Leu Glu His Val 
             340                345                350
Ser Arg Glu Gln Ile Arg Glu Val Glu Glu Asp Leu Asp Glu Leu Tyr 
         355                360                365
Asp Ser Leu Glu Met Tyr Asn Pro Ser Asp Ser Gly Pro Glu Met Glu 
     370                375                380
Glu Thr Glu Ser Ile Leu Ser Thr Pro Lys Pro Lys Leu Lys Pro Phe 
 385                390                395                400
Phe Glu Gly Met Ser Gln Ser Ser Ser Gln Thr Glu Ile Gly Ser Leu 
                 405                410                415
Asn Ser Lys Gly Ser Leu Gly Lys Asp Thr Thr Ser Pro Met Glu Leu 
             420                425                430
Ala Ala Leu Glu Lys Val Lys Ser Thr Trp Ile Lys Asn Gln Asp Asp 
         435                440                445
Ser Leu Thr Glu Thr Asp Thr Leu Glu Ile Thr Asp Gln Asp Met Phe 
     450                455                460
Gly Asp Ala Ser Thr Ser Leu Val Val Pro Glu Lys Val Lys Thr Pro 
 465                470                475                480
Met Lys Ser Ser Lys Ala Asp Leu Gln Gly Ser Ala Ser Pro Ser Lys 
                 485                490                495
Val Glu Gly Thr His Thr Pro Arg Gln Lys Arg Ser Thr Pro Leu Lys 
             500                505                510
Glu Arg Gln Leu Ser Lys Pro Leu Ser Glu Arg Thr Asn Ser Ser Asp 
         515                520                525
Ser Glu Arg Ser Pro Asp Leu Gly His Ser Thr Gln Ile Pro Arg Lys 
     530                535                540
Val Val Tyr Asp Gln Leu Asn Gln Ile Leu Val Ser Asp Ala Ala Leu 
 545                550                555                560
Pro Glu Asn Val Ile Leu Val Asn Thr Thr Asp Trp Gln Gly Gln Tyr 
                 565                570                575
Val Ala Glu Leu Leu Gln Asp Gln Arg Lys Pro Val Val Cys Thr Cys 
             580                585                590
Ser Thr Val Glu Val Gln Ala Val Leu Ser Ala Leu Leu Thr Arg Ile 
         595                600                605
Gln Arg Tyr Cys Asn Cys Asn Ser Ser Met Pro Arg Pro Val Lys Val 
     610                615                620
Ala Ala Val Gly Ser Gln Ser Tyr Leu Ser Ser Ile Leu Arg Phe Phe 
 625                630                635                640
Val Lys Ser Leu Ala Ser Lys Thr Pro Asp Trp Leu Gly His Met Arg 
                 645                650                655
Phe Leu Ile Val Pro Leu Gly Ser His Pro Val Ala Lys Tyr Leu Gly 
             660                665                670
Ser Val Asp Ser Arg Tyr Ser Ser Thr Phe Leu Asp Ser Ala Trp Arg 
         675                680                685
Asp Leu Phe Ser Arg Ser Glu Pro Pro Val Ser Glu Pro Leu Asp Val 
     690                695                700
Val Gly Arg Val Met Gln Tyr Val Asn Gly Ala Thr Thr Thr His Gln 
 705                710                715                720
Leu Pro Val Ala Glu Ala Met Leu Thr Cys Arg His Lys Phe Pro Asp 
                 725                730                735
Glu Asp Ser Tyr Gln Lys Phe Ile Pro Phe Ile Gly Val Val Lys Val 
             740                745                750
Gly Leu Val Glu Asp Ser Pro Ser Thr Ala Gly Asp Gly Asp Asp Ser 
         755                760                765
Pro Val Val Ser Leu Thr Val Pro Ser Thr Ser Pro Pro Ser Ser Ser 
     770                775                780
Gly Leu Ser Arg Asp Ala Thr Ala Thr Pro Pro Ser Ser Pro Ser Met 
 785                790                795                800
Ser Ser Ala Leu Ala Ile Val Gly Ser Pro Asn Ser Pro Tyr Gly Asp 
                 805                810                815
Val Ile Gly Leu Gln Val Asp Tyr Trp Leu Gly His Pro Gly Glu Arg 
             820                825                830
Arg Arg Glu Gly Asp Lys Arg Asp Ala Ser Ser Lys Asn Thr Leu Lys 
         835                840                845
Ser Val Phe Arg Ser Val Gln Val Ser Arg Leu Pro His Ala Gly Glu 
     850                855                860
Ala Gln Leu Ser Gly Thr Met Ala Met Thr Val Val Thr Lys Glu Lys 
 865                870                875                880
Asn Lys Lys Val Pro Thr Ile Phe Leu Ser Lys Lys Pro Arg Glu Lys 
                 885                890                895
Glu Val Asp Ser Lys Ser Gln Val Ile Glu Gly Ile Ser Arg Leu Ile 
             900                905                910
Cys Ser Ala Lys Gln Gln Gln Thr Met Leu Arg Val Ser Ile Asp Gly 
         915                920                925
Val Glu Trp Ser Asp Ile Lys Phe Phe Gln Leu Ala Ala Gln Trp Pro 
     930                935                940
Thr His Val Lys His Phe Pro Val Gly Leu Phe Ser Gly Ser Lys Pro 
 945                950                955                960
Thr 
                 965



<210> 1078
<211> 1765
<212> DNA
<213> Homo sapiens
<308> AL137271
<400> 1078

gaaaccccg  gaaaaggag  tggattcta  gagccaggt  attgaaggc  tcagccgcc  60
catctgctc  gccaagcag  agcagacta  gctgagagt  tccatcgat  gggtcgagt  120
gagtgacat  aagttcttc  agctggcag  ccagtggcc  acccatgtc  agcactttc  180
agtgggact  ttcagtggc  gcaaggcca  ctgaggccc  gtctcccag  cactttccc  240
cctggcact  ccaccagcc  caccgcctg  gggcagggg  aggccagca  gcccgggcc  300
agcacccct  ccctggcac  agggtctgc  tctcactcg  ccaggtccc  aaggacact  360
ccacaggga  gccttccct  ccctcccct  cagcccacc  ctgcacagc  cctcctcct  420
cccgctttt  cccttctcc  tcctgctcc  ggcccaagg  gtgttggtt  tgccttctg  480
tgcccatag  cccctggac  gagtccccc  ggccttcct  cacccgact  ccaaactct  540
ccttgtggt  tcagtttcc  tctcggaaa  gagaaagct  gaatcctgg  ccccagcag  600
agagcctag  cctccccca  cccctccag  caccagggt  tcctctagg  tgcagctgc  660
agatccact  actctgctg  ctccagcag  acccaaggc  actttcaac  cttatgggg  720
tctccacct  ccccagagc  tctcaaggg  gggtaaggg  gcaccctga  cccacagga  780
ccctacttc  cagctcaca  gggcaggag  cagctcccc  gcctccagg  ccctgttgc  840
atggtgaca  agcgtttct  ggacagagg  gcctcccag  ctcccccca  cacccgtgc  900
cgacttcct  accaccccc  ggttccctg  agatgtcgt  tgtgtcctg  gtgtttctt  960
ggttctttg  acgccaagt  tcttggttg  accatgtga  acaccctgt  cactggtcg  1020
tgtcttcgt  gcttccacc  ttgttaatg  tgctcctgc  tctgcctcc  agcccctca  1080
ccagcacag  tctgcctgg  cttggagag  tgggaggca  acccccacc  ccatacatg  1140
tgtctgtgg  ccctcagac  ttctgtttc  tctcccatt  atctccctc  tcccaccgt  1200
tcagttttt  tgcctttcc  tgctctgtt  ttccccctc  ttaggcccc  gcctgggcc  1260
agacccatc  tcccagcca  gtttccctc  agcaggctc  ttccctccc  gtcacctcc  1320
tctcaccaa  ccggggtct  agcccctca  tcctgaccg  ccgtgttct  aggagtggt  1380
gaggacaca  ggccccagc  cagccctct  cacccccca  cccggccat  tgcgcccca  1440
agccccttt  gagcttttc  cttgtcctc  cactccttc  cagaagttt  tgcacagaa  1500
ttcattttg  aagtgtttt  ctcattctc  atacctccc  caagctctc  tccagccct  1560
cccagggct  agccctgct  tcctgagcg  ctcctgggc  agagagagg  gatgggggt  1620
ggagggact  agttgatgt  gggtttttc  ttcaataaa  tggtgattt  tttaaaaaa  1680
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1740
aaaaaaaaa  aaaaaaaaa  aaaaa  1765



<210> 1079
<211> 4198
<212> DNA
<213> Rattus norvegicus
<308> AF076183
<400> 1079

gacgcgctg  gccgctgcc  ccgcggggg  gaagcctgc  agtagctcg  gtgcccgca  60
tccgcgtaa  ccccgcgcc  cttccaccc  tggccaggc  atggcggaa  gtggagggg  120
gggcggtgg  cccggaggc  ccgggggcg  cagcagtca  cggggctct  gggttgccc  180
gtccccgca  cagcagccg  cgcagcagc  atctcagcc  caacagcca  cgcccccca  240
actggccca  gccacctcg  cctcctcgt  cacctcggc  gcggccgcc  cctcctcgt  300
ctcctccac  tccacctcc  tggccgtcg  ggtggcctc  ggctctgcg  ctcccggcg  360
tccgggacc  ggccgcacc  ccgccccag  gcagatgaa  ttgtatgct  cctgggagg  420
ggaccggag  tcatccagc  gcgtgccca  actcttcag  ttgactctg  agaaacttg  480
tatgcttaa  gaaatggac  aagatctta  ctcagtagt  attgctgtg  agctgcagg  540
ttcaaaaag  attcttcgc  ctaatgaga  catccttcc  gccagtggc  tggtggaaa  600
agagctcca  ttaaccttc  ccctccagt  ccctcattt  cttaagcga  atgccaaca  660
actgcagat  atgttgcaa  ggaggaagc  gtacaagaa  cggactatc  tgggctata  720
aaccttggc  gtgggactc  tcaacatgg  agaggtgat  caacaccct  acgagggtg  780
tttagtact  ggcctgcat  gcaacgtaa  ggatgtctc  gtgcctgtg  cagaaataa  840
aatctactc  ttatccagc  agcccattg  ccatgaagg  atcaagtct  agctgtctg  900
tcgctcccc  gatattgac  actactctg  agaagagga  gaaagcttc  cctcagagc  960
ggaaggcag  gatgaccca  tacatggac  ggacctatt  tatgaagat  aagatcttc  1020
gaaagtaaa  aagactcga  ggaaactga  ctcaacctc  gccatcact  ggcaaccga  1080
catcaaaca  aagtttgtg  ccctcctga  acgattcaa  gtttctgat  aggtgggct  1140
tgggctaga  catgtgtca  gggagcaga  tcgggaagt  gaagaggac  tggatgaac  1200
atacgacag  ctagaaatg  acaacccca  cgacagtgg  cctgagatg  aagaaacag  1260
aagcatcct  agcacccca  agcccaagc  caagccctt  tttgagggg  tgtctcagt  1320
cagctcaca  acggagatc  gcagtctca  cagcaaggg  agccttgga  aagacacca  1380
cagccctat  gaattggca  ctttagaaa  agttaagtc  acttggatt  aaaaccaag  1440
tgacagctt  actgaaaca  acactttag  aatcactga  caggacatg  ttggagatg  1500
gagcacaag  ctggttgta  cagaaaaag  caaaactcc  atgaagtcc  gcaaagctg  1560
tctgcaggg  tccgcctcg  cgagcaagg  ggaagggac  cacacacct  gccaaaaga  1620
gagcactcc  ctgaaggag  ggcagctct  caagcccct  agtgagagg  ccaacagct  1680
tgacagtga  cgctctcct  acctagggc  cagcacaca  attccacga  aggtggtat  1740
cgatcaact  aatcagatc  tggtttccg  tgcagcgct  cctgagaat  tcatcctgg  1800
gaacaccac  gactggcag  gccagtatg  ggccgaatt  cttcaagac  agaggaagc  1860
tgttgtgtg  acctgctca  cagtggagg  ccaggccgt  ttgtctgcc  tgctcacta  1920
gattcagcg  tactgcaac  gcaactcat  tatgccgag  ccagtcaag  tggcagctg  1980
gggcagcca  agttacctg  gctccatcc  tcggttttt  gtcaagtcc  ttgccagca  2040
gaccccgga  tggctgggc  acatgcgct  cctcatcgt  cccctaggt  ctcatccag  2100
ggccaaata  ttgggctca  tagatagta  atatagcag  acctttctt  attctgctt  2160
gagagacct  ttcagtcgc  cagagcctc  agtgtcaga  ccactggat  tggtgggtc  2220
tgtgatgca  tatgtcaat  gagctacca  aacgcacca  ctgcctgtg  ctgaagcca  2280
gttgacctg  aggcataag  tccctgatg  agactccta  cagaagttt  tccccttca  2340
tggtgttgt  aaagtgggc  ttgttgaag  ctcgccctc  actgcaggt  atggggacg  2400
ttcacctgt  gtcagcctt  ctgtgccct  cacatcacc  ccctcaagc  cgggcctga  2460
ccgagatgc  acagctacc  ctccctcat  cccatccat  agcagtgcc  tcgccatcg  2520
ggggagccc  aatagccct  atggggatg  gattggcct  caggtggat  actggctgg  2580
ccaccctgg  gagcgaagg  gagaaggtg  taagaggga  gccagttca  agaataccc  2640
caagagtgt  ttccgctca  tgcaggttt  tcgcctgcc  catgcaggg  aagcccagc  2700
ttctggcac  atggcaatg  ctgtggtca  caaagagaa  aacaagaaa  tgcccacta  2760
cttcctgag  aagaagccc  gggaaaagg  ggtggattc  aagagccaa  tcatcgagg  2820
catcagccg  ctcatctgt  ctgcaaagc  gcagcaaac  atgctgaga  tgtccattg  2880
tggagttga  tggagtgac  tcaagttct  ccagctggc  gctcagtgg  ccactcatg  2940
caagcactt  ccagtggga  tcttcagtg  cagcaaacc  acctgagac  tgcctccca  3000
ccactccct  ctggcactg  cacccagcc  agcctcctt  cctagcact  gggcttgcc  3060
ccacttgcc  agtcctgaa  gacactgcc  ctggggatg  agtcctccc  gctcactgc  3120
cagccatct  tgcccagct  ccccctgtt  caggcccag  gctgggtga  cctgccttc  3180
ggtgcccat  attcctgta  ttgaataat  tgggccttc  ttcacctca  ccctgcagc  3240
ctggtaccc  ttctagaaa  gaaacacct  gagttctgg  acacaggga  acagcccag  3300
atcctacat  agctggcca  ccagctctg  atttctaag  ctctgttgc  tgttgtact  3360
accctgcct  cctccagca  ggctggggc  tcctgccat  cctcacctg  ctcacagtt  3420
cccagtagg  ggaaggagg  tggcacctg  gcatcctgg  gtttctggg  ttgaaggga  3480
cttcccagt  tcccatgca  gatttcctg  cacttcaag  cgcttggat  tcctgtgtt  3540
tgtgtgttt  tagttgttt  ggtaacttg  cctgtgcac  ggtccttaa  gctccttct  3600
cctctgcct  ccagcctcc  acctaacat  gctctgtgg  ttcatgagg  aggagacag  3660
aaacccacc  acccaccca  cccttcacc  ctcaacaca  acatcatct  tggctctca  3720
ccagtcata  tgtccccct  tcctgtgtc  gcttgcctc  tggctctgc  ctgtcatcc  3780
acttccttc  tggcagggc  gcagaatga  gcccttctc  accaggtct  cctccagca  3840
cctccttcc  tctctcagc  atgaatggg  cccagacct  cctcagcct  cttatcagt  3900
tcttcatga  aggctgagg  caagggaca  atctggccc  gcctccatg  cctctgtgt  3960
ctatggcac  tcagagctt  tccgttgcc  ctcagtgtt  cctagcagt  tggcacgga  4020
ctgcacttg  aacctagtt  tggtgttct  cacatccaa  actcttaag  ccctcccgc  4080
gcccagcct  tccagagta  ctcctgggc  tgagaataa  tggggtggg  agactgggg  4140
catgttggg  tttttcatt  aataaactg  tgatttctt  ccaaaaaaa  aaaaaaaa  4198



<210> 1080
<211> 961
<212> PRT
<213> Rattus norvegicus
<308> AAC31815
<400> 1080

Met Ala Glu Arg Gly Gly Ala Gly Gly Gly Pro Gly Gly Ala Gly Gly 
  1               5                  10                  15
Gly Ser Ser Gln Arg Gly Ser Gly Val Ala Gln Ser Pro Gln Gln Gln 
             20                  25                  30
Pro Pro Gln Gln Pro Ser Gln Pro Gln Gln Pro Thr Pro Pro Lys Leu 
         35                  40                  45
Ala Gln Ala Thr Ser Ser Ser Ser Ser Thr Ser Ala Ala Ala Ala Ser 
     50                  55                  60
Ser Ser Ser Ser Ser Thr Ser Thr Ser Met Ala Val Ala Val Ala Ser 
 65                  70                  75                  80
Gly Ser Ala Pro Pro Gly Gly Pro Gly Pro Gly Arg Thr Pro Ala Pro 
                 85                  90                  95
Val Gln Met Asn Leu Tyr Ala Thr Trp Glu Val Asp Arg Ser Ser Ser 
             100                105                110
Ser Cys Val Pro Arg Leu Phe Ser Leu Thr Leu Lys Lys Leu Val Met 
         115                120                125
Leu Lys Glu Met Asp Lys Asp Leu Asn Ser Val Val Ile Ala Val Lys 
     130                135                140
Leu Gln Gly Ser Lys Arg Ile Leu Arg Ser Asn Glu Ile Ile Leu Pro 
 145                150                155                160
Ala Ser Gly Leu Val Glu Thr Glu Leu Gln Leu Thr Phe Ser Leu Gln 
                 165                170                175
Tyr Pro His Phe Leu Lys Arg Asp Ala Asn Lys Leu Gln Ile Met Leu 
             180                185                190
Gln Arg Arg Lys Arg Tyr Lys Asn Arg Thr Ile Leu Gly Tyr Lys Thr 
         195                200                205
Leu Ala Val Gly Leu Ile Asn Met Ala Glu Val Met Gln His Pro Asn 
     210                215                220
Glu Gly Ala Leu Val Leu Gly Leu His Ser Asn Val Lys Asp Val Ser 
 225                230                235                240
Val Pro Val Ala Glu Ile Lys Ile Tyr Ser Leu Ser Ser Gln Pro Ile 
                 245                250                255
Asp His Glu Gly Ile Lys Ser Lys Leu Ser Asp Arg Ser Pro Asp Ile 
             260                265                270
Asp Asn Tyr Ser Glu Glu Glu Glu Glu Ser Phe Ser Ser Glu Gln Glu 
         275                280                285
Gly Ser Asp Asp Pro Leu His Gly Gln Asp Leu Phe Tyr Glu Asp Glu 
     290                295                300
Asp Leu Arg Lys Val Lys Lys Thr Arg Arg Lys Leu Thr Ser Thr Ser 
 305                310                315                320
Ala Ile Thr Arg Gln Pro Asn Ile Lys Gln Lys Phe Val Ala Leu Leu 
                 325                330                335
Lys Arg Phe Lys Val Ser Asp Glu Val Gly Phe Gly Leu Glu His Val 
             340                345                350
Ser Arg Glu Gln Ile Arg Glu Val Glu Glu Asp Leu Asp Glu Leu Tyr 
         355                360                365
Asp Ser Leu Glu Met Tyr Asn Pro Ser Asp Ser Gly Pro Glu Met Glu 
     370                375                380
Glu Thr Glu Ser Ile Leu Ser Thr Pro Lys Pro Lys Leu Lys Pro Phe 
 385                390                395                400
Phe Glu Gly Met Ser Gln Ser Ser Ser Gln Thr Glu Ile Gly Ser Leu 
                 405                410                415
Asn Ser Lys Gly Ser Leu Gly Lys Asp Thr Thr Ser Pro Met Glu Leu 
             420                425                430
Ala Ala Leu Glu Lys Val Lys Ser Thr Trp Ile Lys Asn Gln Asp Asp 
         435                440                445
Ser Leu Thr Glu Thr Asp Thr Leu Glu Ile Thr Asp Gln Asp Met Phe 
     450                455                460
Gly Asp Ala Ser Thr Ser Leu Val Val Pro Glu Lys Val Lys Thr Pro 
 465                470                475                480
Met Lys Ser Ser Lys Ala Asp Leu Gln Gly Ser Ala Ser Pro Ser Lys 
                 485                490                495
Val Glu Gly Thr His Thr Pro Arg Gln Lys Arg Ser Thr Pro Leu Lys 
             500                505                510
Glu Arg Gln Leu Ser Lys Pro Leu Ser Glu Arg Thr Asn Ser Ser Asp 
         515                520                525
Ser Glu Arg Ser Pro Asp Leu Gly His Ser Thr Gln Ile Pro Arg Lys 
     530                535                540
Val Val Tyr Asp Gln Leu Asn Gln Ile Leu Val Ser Asp Ala Ala Leu 
 545                550                555                560
Pro Glu Asn Val Ile Leu Val Asn Thr Thr Asp Trp Gln Gly Gln Tyr 
                 565                570                575
Val Ala Glu Leu Leu Gln Asp Gln Arg Lys Pro Val Val Cys Thr Cys 
             580                585                590
Ser Thr Val Glu Val Gln Ala Val Leu Ser Ala Leu Leu Thr Arg Ile 
         595                600                605
Gln Arg Tyr Cys Asn Cys Asn Ser Ser Met Pro Arg Pro Val Lys Val 
     610                615                620
Ala Ala Val Gly Ser Gln Ser Tyr Leu Ser Ser Ile Leu Arg Phe Phe 
 625                630                635                640
Val Lys Ser Leu Ala Ser Lys Thr Pro Asp Trp Leu Gly His Met Arg 
                 645                650                655
Phe Leu Ile Val Pro Leu Gly Ser His Pro Val Ala Lys Tyr Leu Gly 
             660                665                670
Ser Val Asp Ser Arg Tyr Ser Ser Thr Phe Leu Asp Ser Ala Trp Arg 
         675                680                685
Asp Leu Phe Ser Arg Ser Glu Pro Pro Val Ser Glu Pro Leu Asp Val 
     690                695                700
Val Gly Arg Val Met Gln Tyr Val Asn Gly Ala Thr Thr Thr His Gln 
 705                710                715                720
Leu Pro Val Ala Glu Ala Met Leu Thr Cys Arg His Lys Phe Pro Asp 
                 725                730                735
Glu Asp Ser Tyr Gln Lys Phe Ile Pro Phe Ile Gly Val Val Lys Val 
             740                745                750
Gly Leu Val Glu Asp Ser Pro Ser Thr Ala Gly Asp Gly Asp Asp Ser 
         755                760                765
Pro Val Val Ser Leu Thr Val Pro Ser Thr Ser Pro Pro Ser Ser Ser 
     770                775                780
Gly Leu Ser Arg Asp Ala Thr Ala Thr Pro Pro Ser Ser Pro Ser Met 
 785                790                795                800
Ser Ser Ala Leu Ala Ile Val Gly Ser Pro Asn Ser Pro Tyr Gly Asp 
                 805                810                815
Val Ile Gly Leu Gln Val Asp Tyr Trp Leu Gly His Pro Gly Glu Arg 
             820                825                830
Arg Arg Glu Gly Asp Lys Arg Asp Ala Ser Ser Lys Asn Thr Leu Lys 
         835                840                845
Ser Val Phe Arg Ser Val Gln Val Ser Arg Leu Pro His Ala Gly Glu 
     850                855                860
Ala Gln Leu Ser Gly Thr Met Ala Met Thr Val Val Thr Lys Glu Lys 
 865                870                875                880
Asn Lys Lys Val Pro Thr Ile Phe Leu Ser Lys Lys Pro Arg Glu Lys 
                 885                890                895
Glu Val Asp Ser Lys Ser Gln Val Ile Glu Gly Ile Ser Arg Leu Ile 
             900                905                910
Cys Ser Ala Lys Gln Gln Gln Thr Met Leu Arg Val Ser Ile Asp Gly 
         915                920                925
Val Glu Trp Ser Asp Ile Lys Phe Phe Gln Leu Ala Ala Gln Trp Pro 
     930                935                940
Thr His Val Lys His Phe Pro Val Gly Leu Phe Ser Gly Ser Lys Pro 
 945                950                955                960
Thr 
                 965



<210> 1081
<211> 1765
<212> DNA
<213> Homo sapiens
<308> AL137271
<400> 1081

gaaaccccg  gaaaaggag  tggattcta  gagccaggt  attgaaggc  tcagccgcc  60
catctgctc  gccaagcag  agcagacta  gctgagagt  tccatcgat  gggtcgagt  120
gagtgacat  aagttcttc  agctggcag  ccagtggcc  acccatgtc  agcactttc  180
agtgggact  ttcagtggc  gcaaggcca  ctgaggccc  gtctcccag  cactttccc  240
cctggcact  ccaccagcc  caccgcctg  gggcagggg  aggccagca  gcccgggcc  300
agcacccct  ccctggcac  agggtctgc  tctcactcg  ccaggtccc  aaggacact  360
ccacaggga  gccttccct  ccctcccct  cagcccacc  ctgcacagc  cctcctcct  420
cccgctttt  cccttctcc  tcctgctcc  ggcccaagg  gtgttggtt  tgccttctg  480
tgcccatag  cccctggac  gagtccccc  ggccttcct  cacccgact  ccaaactct  540
ccttgtggt  tcagtttcc  tctcggaaa  gagaaagct  gaatcctgg  ccccagcag  600
agagcctag  cctccccca  cccctccag  caccagggt  tcctctagg  tgcagctgc  660
agatccact  actctgctg  ctccagcag  acccaaggc  actttcaac  cttatgggg  720
tctccacct  ccccagagc  tctcaaggg  gggtaaggg  gcaccctga  cccacagga  780
ccctacttc  cagctcaca  gggcaggag  cagctcccc  gcctccagg  ccctgttgc  840
atggtgaca  agcgtttct  ggacagagg  gcctcccag  ctcccccca  cacccgtgc  900
cgacttcct  accaccccc  ggttccctg  agatgtcgt  tgtgtcctg  gtgtttctt  960
ggttctttg  acgccaagt  tcttggttg  accatgtga  acaccctgt  cactggtcg  1020
tgtcttcgt  gcttccacc  ttgttaatg  tgctcctgc  tctgcctcc  agcccctca  1080
ccagcacag  tctgcctgg  cttggagag  tgggaggca  acccccacc  ccatacatg  1140
tgtctgtgg  ccctcagac  ttctgtttc  tctcccatt  atctccctc  tcccaccgt  1200
tcagttttt  tgcctttcc  tgctctgtt  ttccccctc  ttaggcccc  gcctgggcc  1260
agacccatc  tcccagcca  gtttccctc  agcaggctc  ttccctccc  gtcacctcc  1320
tctcaccaa  ccggggtct  agcccctca  tcctgaccg  ccgtgttct  aggagtggt  1380
gaggacaca  ggccccagc  cagccctct  cacccccca  cccggccat  tgcgcccca  1440
agccccttt  gagcttttc  cttgtcctc  cactccttc  cagaagttt  tgcacagaa  1500
ttcattttg  aagtgtttt  ctcattctc  atacctccc  caagctctc  tccagccct  1560
cccagggct  agccctgct  tcctgagcg  ctcctgggc  agagagagg  gatgggggt  1620
ggagggact  agttgatgt  gggtttttc  ttcaataaa  tggtgattt  tttaaaaaa  1680
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1740
aaaaaaaaa  aaaaaaaaa  aaaaa  1765



<210> 1082
<211> 4521
<212> DNA
<213> Rattus norvegicus
<308> AF077354
<400> 1082

cggcgcctc  tctgcggcc  tggagccgg  gccggcctg  gcggtagag  cccgtcttt  60
tcaaggacc  aagcatcct  gtggacggt  gtccggctt  gcccgccca  ccgcggtgc  120
ccatcagcc  acgcggcgc  ccctctcca  gcgccaacc  cgtcgggtt  cgtgtgcag  180
gtcggcggc  ggccctggg  ccgagcccg  gcagtagcc  gcgccatgt  ggtggtggg  240
atagacctg  gctttcaga  ctgctatgt  gctgtggcc  gcgccggcg  cattgagac  300
atcgctaat  agtatagcg  ccgctgcac  ccggcttgt  tttctttcg  tcctaagaa  360
cgttcagtt  gagcagcag  aaagagcca  gtaatttcc  atgccaaga  cacagttca  420
gggtttaaa  gatttcatg  gcgtgcatt  tcagatcca  ttgtggaag  agaaaaatc  480
aaccttgca  atgatattg  acagttgcc  actggatta  cgggcataa  ggttacata  540
atggaagaa  agaggaatt  taccactga  caagtgact  ccatgctct  gtcaaaact  600
aaggagaca  cagaaagtg  tcttaagaa  cctgttgta  actgtgttg  ttcggttcc  660
agtttctac  ctgatgcag  acgacggtc  gtgatggat  ccacacaga  tgctggtct  720
aattgcttg  ggttaatga  tgaaacaac  gcagttgct  ttgcttatg  aatctataa  780
caagacctt  ctgccttag  agaaaaacc  agaaatgta  tttttgtag  tatgggaca  840
tctgcctat  aagtttctg  atgtgcatt  aatagagga  aactgaaag  tttggccac  900
gcttttgat  caacattgg  aggcagaaa  tttgatgag  tgttggtaa  tcacttctg  960
gaagaattt  gaaagaaat  caagctaga  ataaaatct  aagttcgtg  tttattgcg  1020
ctctctcaa  agtgtgaga  actcaagaa  ttaatgagt  cgaatgctt  agacctccc  1080
ttgagtatt  aatgcttta  gaacgatat  gatgtatcg  gaaccatga  tagaggcaa  1140
tttttggag  tgtgtgatg  tctcttagc  agagtggag  cgccacttc  tagcatctt  1200
gaccaatcc  agttaaaga  agaagatat  tatgcagtg  agatagttg  tggagccac  1260
cggatccct  ccgtgaaag  gaagatcag  aagttcttt  gtaaagaac  cagcacaac  1320
ttaaatgcg  atgaagcag  cactcgagg  tgtgctctg  agtgtgcaa  cttatcacc  1380
gctttcaaa  tcagagaat  ttctatcac  gatgtggta  catatccaa  atctttgag  1440
tggaattct  cagctgaag  ggggtcaag  gactgtgaa  tcttcccca  aaaccatgc  1500
gctcctttc  ccaaagtcc  cacctttta  agaaaggaa  cgttcactc  ggaggccta  1560
tatagttct  ctcaggatt  gccctatcc  gatcctgct  tagctcagt  ttcagttca  1620
aaagtcact  cacagtctg  tggctccag  tcaaaagtg  aagtcaagg  ccgggtaaa  1680
gtgcatggc  ttttcagtg  gtccagtgc  gccttagta  aggtgcaca  gtccgagga  1740
agcgaggag  caatggaga  tgatcagaa  gcaaaggaa  aagagaaga  gcaggtgga  1800
caggaagaa  cacatactg  agagcaaca  ccacagaca  cagcagaaa  caaggcgga  1860
tctgaggag  tggagacct  tcaagctgg  tcaaaagat  aaaagatgg  ccaaccacc  1920
caagcaaag  aggcaaaag  gaagaccag  accgtggac  tgcccattg  gagccagct  1980
ctgtggcag  tggaccggg  aatgctcgg  ctgtacaca  agaatgagg  taagatgat  2040
atgcaggat  aactggaga  ggaacggaa  gacgccaaa  atgcggtgg  agagtatgt  2100
tatgagatg  gagacaaac  tagtggtga  tatgagaag  ttgtgagtg  agatgatcg  2160
aataatttt  ctttgaaat  agaggatac  gaaaactgg  tgtatgaag  tggagaaga  2220
caaccaaag  aagtttatg  agacaaatt  gctgagtta  gaactttag  tcaacctat  2280
aagacacgg  tccaggaat  tgaagaaag  ccaaaatta  ttgaagaat  agggaagca  2340
atccaacag  atatgaaag  gatcagctc  ttcaaaaac  aggaggacc  gtatgaaca  2400
ttggatgct  ctgacatga  aaaggtaga  aaaagcacc  atgaggcga  ggagtggat  2460
aatagtaag  tgaacctgc  gaacaaaca  agcctgacg  cggatccag  tgtcaagac  2520
aaagagatt  aagctaaaa  taaggagct  acaaatatt  gcagtccta  aatttcaaa  2580
cccaaaccc  aagtggaac  ccctaagga  gaaccaaaa  atgctgagc  gaatggacc  2640
gtggatggc  aaggagaca  cccaggcac  caagctgct  agcacggtg  agacacagc  2700
gtgccttct  atggtgaca  gaagcttcc  gagatggac  ttgattgat  ccaacactt  2760
tttatatta  aacagacta  tataaagct  taagttgtc  actttgttc  gaatatcaa  2820
tagagcaag  aaatactgg  gatttctta  tcagttttt  ggggatctc  gggtggggt  2880
tataggtaa  atacagagc  ttttgactt  taaatagtt  gatccagag  tgaagtgca  2940
tgttctctc  tcattatga  cctgtttaa  agcccagct  gtctttctg  gctcttgcc  3000
ccctccttg  tttaatcat  cttctacaa  gtgaagtgt  tttggggaa  ctgagctct  3060
acaaaagct  tgagagcca  taggcaggc  tttcctcaa  catgacaga  gttcaaatt  3120
tgcttggaa  ggctgagtg  agatcacca  cagcattct  tgcctgtgg  gctgtggga  3180
tgtggggct  gtgcttcct  catttctga  ggtctgaga  tggcccagc  tgcattaac  3240
caggagagc  cagagcgca  cagggcctg  tctcattgc  ctctattcc  agccctgtc  3300
tcctcttcc  tccgcaagc  gtataaatg  catgtgccc  ctgcactta  agtgagcct  3360
agcgtatca  ggggctttg  cgtggctcc  cgtacttcc  gaaagtatt  actgacact  3420
aagcgtcag  gtctagtgt  accttaagg  aggttgtaa  taacagttg  ctgtaggca  3480
ggtaagtct  agcagccca  ccttagtgt  gtgggaagg  ctgtaccct  acctgctcc  3540
cggtagatg  tgtatgtaa  ttagaggtt  cgatggaac  ggatgagag  tcaaggttc  3600
ttgtttggt  ttatttgtg  taatgtgtc  tgaatctgc  aatctgtat  ttaaaacag  3660
tgacagatt  taaagctat  gccctggac  agtctgaaa  tagtgtaaa  gaaaacctc  3720
tcgttaact  cagccgctg  cagggtacc  tatattcct  gaacaagtc  atggggaag  3780
gatgttctg  agacaaagg  acggatgcc  atggtagag  tcagagttg  ttacctgcc  3840
tagttacaa  tgttacgtt  tgggtcttt  taatcactg  tctctgtaa  agagcctct  3900
tttattctt  cttgttgga  ataagctta  accatgcat  gttagaatt  ctatgcttc  3960
gtctacaca  gaagtgctg  agctctcaa  tgctctaga  gccattggt  ggagaggaa  4020
gaatgcatg  ttatgttat  taagcaact  gactcccgc  cagtacagg  ctggagctc  4080
aggccgagt  catactctg  tgctttgag  gctgcagga  tgcccactg  cctggctgt  4140
aggctgata  ctttttcaa  tgcaggctg  aggattaag  caactctta  gcaactgac  4200
gtccttaat  atgatctca  aaacatttg  gtgtggggg  gggagggtt  gggtgtcgg  4260
atggggaat  aatttgaag  ctaaagtta  agctagaaa  cagatgatc  gcttctgct  4320
tgtctatat  gacgattgg  tttatgtgg  ggcaggcca  atggcaact  atgacttgt  4380
tgcaaacaa  catttatcc  ggttgcaat  tccaaattg  tttgttaaa  actctaggt  4440
acattctta  actaagaaa  acagtaaac  tgagacaaa  tttaggaaa  actaataaa  4500
gaaacctgt  ttaacttga  a  4521



<210> 1083
<211> 999
<212> PRT
<213> Rattus norvegicus
<308> Q63617
<400> 1083

Met Ala Ala Thr Val Arg Arg Gln Arg Pro Arg Arg Leu Leu Cys Trp 
  1               5                  10                  15
Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
             20                  25                  30
Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
         35                  40                  45
Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
     50                  55                  60
Arg Arg Lys Thr Pro Val Thr Val Thr Leu Lys Glu Asn Glu Arg Phe 
 65                  70                  75                  80
Leu Gly Asp Ser Ala Ala Gly Met Ala Ile Lys Asn Pro Lys Ala Thr 
                 85                  90                  95
Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
             100                105                110
Val Ala Leu Tyr Arg Ser Arg Phe Pro Glu His Glu Leu Asn Val Asp 
         115                120                125
Pro Gln Arg Gln Thr Val Arg Phe Gln Ile Ser Pro Gln Leu Gln Phe 
     130                135                140
Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
 145                150                155                160
Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                 165                170                175
Pro Ala Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
             180                185                190
Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
         195                200                205
Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Ser Thr 
     210                215                220
Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
 225                230                235                240
Thr Ile Val Thr Tyr Gln Thr Val Lys Thr Lys Glu Ala Gly Thr Gln 
                 245                250                255
Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
             260                265                270
Leu Glu Met Glu Leu Arg Leu Arg Glu His Leu Ala Lys Leu Phe Asn 
         275                280                285
Glu Gln Arg Lys Gly Gln Lys Ala Lys Asp Val Arg Glu Asn Pro Arg 
     290                295                300
Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
 305                310                315                320
Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                 325                330                335
Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
             340                345                350
Ala Asp Leu Phe Asp Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
         355                360                365
Ser Ala Glu Met Ser Leu Asp Gln Ile Glu Gln Val Ile Leu Val Gly 
     370                375                380
Gly Pro Thr Arg Val Pro Lys Val Gln Glu Val Leu Leu Lys Pro Val 
 385                390                395                400
Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                 405                410                415
Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
             420                425                430
Lys Pro Phe Val Val Arg Asp Ala Val Ile Tyr Pro Ile Leu Val Glu 
         435                440                445
Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Leu Arg Ser Leu Lys His 
     450                455                460
Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
 465                470                475                480
Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                 485                490                495
Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
             500                505                510
Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Glu Ser Phe 
         515                520                525
Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
     530                535                540
Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
 545                550                555                560
Glu Thr Leu Val Glu Asp Ser Pro Glu Glu Glu Ser Thr Leu Thr Lys 
                 565                570                575
Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Ser Ser Asp 
             580                585                590
Ala Lys Glu Asn Gly Thr Asp Ala Val Gln Glu Glu Glu Glu Ser Pro 
         595                600                605
Ala Glu Gly Ser Lys Asp Glu Pro Ala Glu Gln Gly Glu Leu Lys Glu 
     610                615                620
Glu Ala Glu Ala Pro Met Glu Asp Thr Ser Gln Pro Pro Pro Ser Glu 
 625                630                635                640
Pro Lys Gly Asp Ala Ala Arg Glu Gly Glu Thr Pro Asp Glu Lys Glu 
                 645                650                655
Ser Gly Asp Lys Ser Glu Ala Gln Lys Pro Asn Glu Lys Gly Gln Ala 
             660                665                670
Gly Pro Glu Gly Val Pro Pro Ala Pro Glu Glu Glu Lys Lys Gln Lys 
         675                680                685
Pro Ala Arg Lys Gln Lys Met Val Glu Glu Ile Gly Val Glu Leu Ala 
     690                695                700
Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Glu Leu Ala His Ser Val 
 705                710                715                720
Gln Lys Leu Glu Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg 
                 725                730                735
Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp 
             740                745                750
Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg 
         755                760                765
Glu Glu Ile Ser Gly Lys Leu Ser Ala Thr Ser Thr Trp Leu Glu Asp 
     770                775                780
Glu Gly Phe Gly Ala Thr Thr Val Met Leu Lys Asp Lys Leu Ala Glu 
 785                790                795                800
Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Arg 
                 805                810                815
Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser 
             820                825                830
Ser Ile Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile 
         835                840                845
Phe Thr Asp Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Asp Thr 
     850                855                860
Trp Thr Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala 
 865                870                875                880
Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met 
                 885                890                895
Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr 
             900                905                910
Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Thr Glu Pro 
         915                920                925
Pro Leu Asn Ala Ser Ala Gly Asp Gln Glu Glu Lys Val Ile Pro Pro 
     930                935                940
Thr Gly Gln Thr Glu Glu Ala Lys Ala Ile Leu Glu Pro Asp Lys Glu 
 945                950                955                960
Gly Leu Gly Thr Glu Ala Ala Asp Ser Glu Pro Leu Glu Leu Gly Gly 
                 965                970                975
Pro Gly Ala Glu Ser Glu Gln Ala Glu Gln Thr Ala Gly Gln Lys Arg 
             980                985                990
Pro Leu Lys Asn Asp Glu Leu 
         995



<210> 1084
<211> 715
<212> DNA
<213> Homo sapiens
<308> BC002526
<400> 1084

ggcacgagg  gccactgag  cggagccgg  ctgagcagc  ctctcggtt  cagtaccca  60
tggaaggac  taggcgctc  cgtggacac  gcaagcccc  cagtagcct  ggcccaaga  120
gcctgcttt  cactcgcta  ccccgccgg  ggtccgtgt  ctgtctcgg  ggccggacc  180
gggcccgag  ccgagcagt  gccggcgcc  tgtcggtgg  gggcataga  ctgggcttc  240
agagctgct  cgtcgctgt  gcccgcgcc  gcggcatcg  gactatcgc  aatgagtat  300
gcgaccgct  cacgccggc  tgcatttct  ttggtccta  gaatcgttc  attggagca  360
cagctaaaa  ccaggtaat  tctaatgca  agaacacag  ccaaggatt  aaaagattc  420
atggccgag  attctctga  ccatttgtg  aggcagaaa  atctaacct  gcatatgat  480
ttgtgcagt  gcctacagg  ttaacaggt  taaaggtga  atatatgga  gaagagcag  540
atggaccag  ggatggaca  ggagacaac  caggccccc  ggctgctga  cagggtaca  600
acacagctg  gccttcgga  tcagacaag  agcttcctg  aatggacat  gattgattc  660
aacacttgt  tctattaaa  cagactatt  taaaaaaaa  aaaaaaaaa  aaaaa  715



<210> 1085
<211> 840
<212> PRT
<213> Homo sapiens
<308> P34932
<400> 1085

Met Ser Val Val Gly Ile Asp Leu Gly Phe Gln Ser Cys Tyr Val Ala 
  1               5                  10                  15
Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Tyr Ser Asp 
             20                  25                  30
Arg Cys Thr Pro Ala Cys Ile Ser Phe Gly Pro Lys Asn Arg Ser Ile 
         35                  40                  45
Gly Ala Ala Ala Lys Ser Gln Val Ile Ser Asn Ala Lys Asn Thr Val 
     50                  55                  60
Gln Gly Phe Lys Arg Phe His Gly Arg Ala Phe Ser Asp Pro Phe Val 
 65                  70                  75                  80
Glu Ala Glu Lys Ser Asn Leu Ala Tyr Asp Ile Val Gln Leu Pro Thr 
                 85                  90                  95
Gly Leu Thr Gly Ile Lys Val Thr Tyr Met Glu Glu Glu Arg Asn Phe 
             100                105                110
Thr Thr Glu Gln Val Thr Ala Met Leu Leu Ser Lys Leu Lys Glu Thr 
         115                120                125
Ala Glu Ser Val Leu Lys Lys Pro Val Val Asp Cys Val Val Ser Val 
     130                135                140
Pro Cys Phe Tyr Thr Asp Ala Glu Arg Arg Ser Val Met Asp Ala Thr 
 145                150                155                160
Gln Ile Ala Gly Leu Asn Cys Leu Arg Leu Met Asn Glu Thr Thr Ala 
                 165                170                175
Val Ala Leu Ala Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ala Leu Glu 
             180                185                190
Glu Lys Pro Arg Asn Val Val Phe Val Asp Met Gly His Ser Ala Tyr 
         195                200                205
Gln Val Ser Val Cys Ala Phe Asn Arg Gly Lys Leu Lys Val Leu Ala 
     210                215                220
Thr Ala Phe Asp Thr Thr Leu Gly Gly Arg Lys Phe Asp Glu Val Leu 
 225                230                235                240
Val Asn His Phe Cys Glu Glu Phe Gly Lys Lys Tyr Lys Leu Asp Ile 
                 245                250                255
Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Ser Gln Glu Cys Glu Lys 
             260                265                270
Leu Lys Lys Leu Met Ser Ala Asn Ala Ser Asp Leu Pro Leu Ser Ile 
         275                280                285
Glu Cys Phe Met Asn Asp Val Asp Val Ser Gly Thr Met Asn Arg Gly 
     290                295                300
Lys Phe Leu Glu Met Cys Asn Asp Leu Leu Ala Arg Val Glu Pro Pro 
 305                310                315                320
Leu Arg Ser Val Leu Glu Gln Thr Lys Leu Lys Lys Glu Asp Ile Tyr 
                 325                330                335
Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
             340                345                350
Lys Ile Ser Lys Phe Phe Gly Lys Glu Leu Ser Thr Thr Leu Asn Ala 
         355                360                365
Asp Glu Ala Val Thr Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
     370                375                380
Pro Ala Phe Lys Val Arg Glu Phe Ser Ile Thr Asp Val Val Pro Tyr 
 385                390                395                400
Pro Ile Ser Leu Arg Trp Asn Ser Pro Ala Glu Glu Gly Ser Ser Asp 
                 405                410                415
Cys Glu Val Phe Ser Lys Asn His Ala Ala Pro Phe Ser Lys Val Leu 
             420                425                430
Thr Phe Tyr Arg Lys Glu Pro Phe Thr Leu Glu Ala Tyr Tyr Ser Ser 
         435                440                445
Pro Gln Asp Leu Pro Tyr Pro Asp Pro Ala Ile Ala Gln Phe Ser Val 
     450                455                460
Gln Lys Val Thr Pro Gln Ser Asp Gly Ser Ser Ser Lys Val Lys Val 
 465                470                475                480
Lys Val Arg Val Asn Val His Gly Ile Phe Ser Val Ser Ser Ala Ser 
                 485                490                495
Leu Val Glu Val His Lys Ser Glu Glu Asn Glu Glu Pro Met Glu Thr 
             500                505                510
Asp Gln Asn Ala Lys Glu Glu Glu Lys Met Gln Val Asp Gln Glu Glu 
         515                520                525
Pro His Val Glu Glu Gln Gln Gln Gln Thr Pro Ala Glu Asn Lys Ala 
     530                535                540
Glu Ser Glu Glu Met Glu Thr Ser Gln Ala Gly Ser Lys Asp Lys Lys 
 545                550                555                560
Met Asp Gln Pro Pro Gln Ala Lys Lys Ala Lys Val Lys Thr Ser Thr 
                 565                570                575
Val Asp Leu Pro Ile Glu Asn Gln Leu Leu Trp Gln Ile Asp Arg Glu 
             580                585                590
Met Leu Asn Leu Tyr Ile Glu Asn Glu Gly Lys Met Ile Met Gln Asp 
         595                600                605
Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Arg Glu Tyr 
     610                615                620
Val Tyr Glu Met Arg Asp Lys Leu Ser Gly Glu Tyr Glu Lys Phe Val 
 625                630                635                640
Ser Glu Asp Gly Arg Asn Ser Phe Thr Leu Lys Leu Glu Asp Thr Glu 
                 645                650                655
Asn Trp Leu Tyr Glu Asp Gly Glu Asp Gln Pro Lys Gln Val Tyr Val 
             660                665                670
Asp Lys Leu Ala Glu Leu Lys Asn Leu Gly Gln Pro Ile Lys Ile Arg 
         675                680                685
Phe Gln Glu Ser Glu Glu Arg Pro Lys Leu Phe Glu Glu Leu Gly Lys 
     690                695                700
Gln Ile Gln Gln Tyr Met Lys Ile Ile Ser Ser Phe Lys Asn Lys Glu 
 705                710                715                720
Asp Gln Tyr Asp His Leu Asp Ala Ala Asp Met Thr Lys Val Glu Lys 
                 725                730                735
Ser Thr Asn Glu Ala Met Glu Trp Met Asn Asn Lys Leu Asn Leu Gln 
             740                745                750
Asn Lys Gln Ser Leu Thr Met Asp Pro Val Val Lys Ser Lys Glu Ile 
         755                760                765
Glu Ala Lys Ile Lys Glu Leu Thr Ser Thr Cys Ser Pro Ile Ile Ser 
     770                775                780
Lys Pro Lys Pro Lys Val Glu Pro Pro Lys Glu Glu Gln Lys Asn Ala 
 785                790                795                800
Glu Gln Asn Gly Pro Val Asp Gly Gln Gly Asp Asn Pro Gly Pro Gln 
                 805                810                815
Ala Ala Glu Gln Gly Thr Asp Thr Ala Val Pro Ser Asp Ser Asp Lys 
             820                825                830
Lys Leu Pro Glu Met Asp Ile Asp 
         835                840



<210> 1086
<211> 4521
<212> DNA
<213> Rattus norvegicus
<308> AF077354
<400> 1086

cggcgcctc  tctgcggcc  tggagccgg  gccggcctg  gcggtagag  cccgtcttt  60
tcaaggacc  aagcatcct  gtggacggt  gtccggctt  gcccgccca  ccgcggtgc  120
ccatcagcc  acgcggcgc  ccctctcca  gcgccaacc  cgtcgggtt  cgtgtgcag  180
gtcggcggc  ggccctggg  ccgagcccg  gcagtagcc  gcgccatgt  ggtggtggg  240
atagacctg  gctttcaga  ctgctatgt  gctgtggcc  gcgccggcg  cattgagac  300
atcgctaat  agtatagcg  ccgctgcac  ccggcttgt  tttctttcg  tcctaagaa  360
cgttcagtt  gagcagcag  aaagagcca  gtaatttcc  atgccaaga  cacagttca  420
gggtttaaa  gatttcatg  gcgtgcatt  tcagatcca  ttgtggaag  agaaaaatc  480
aaccttgca  atgatattg  acagttgcc  actggatta  cgggcataa  ggttacata  540
atggaagaa  agaggaatt  taccactga  caagtgact  ccatgctct  gtcaaaact  600
aaggagaca  cagaaagtg  tcttaagaa  cctgttgta  actgtgttg  ttcggttcc  660
agtttctac  ctgatgcag  acgacggtc  gtgatggat  ccacacaga  tgctggtct  720
aattgcttg  ggttaatga  tgaaacaac  gcagttgct  ttgcttatg  aatctataa  780
caagacctt  ctgccttag  agaaaaacc  agaaatgta  tttttgtag  tatgggaca  840
tctgcctat  aagtttctg  atgtgcatt  aatagagga  aactgaaag  tttggccac  900
gcttttgat  caacattgg  aggcagaaa  tttgatgag  tgttggtaa  tcacttctg  960
gaagaattt  gaaagaaat  caagctaga  ataaaatct  aagttcgtg  tttattgcg  1020
ctctctcaa  agtgtgaga  actcaagaa  ttaatgagt  cgaatgctt  agacctccc  1080
ttgagtatt  aatgcttta  gaacgatat  gatgtatcg  gaaccatga  tagaggcaa  1140
tttttggag  tgtgtgatg  tctcttagc  agagtggag  cgccacttc  tagcatctt  1200
gaccaatcc  agttaaaga  agaagatat  tatgcagtg  agatagttg  tggagccac  1260
cggatccct  ccgtgaaag  gaagatcag  aagttcttt  gtaaagaac  cagcacaac  1320
ttaaatgcg  atgaagcag  cactcgagg  tgtgctctg  agtgtgcaa  cttatcacc  1380
gctttcaaa  tcagagaat  ttctatcac  gatgtggta  catatccaa  atctttgag  1440
tggaattct  cagctgaag  ggggtcaag  gactgtgaa  tcttcccca  aaaccatgc  1500
gctcctttc  ccaaagtcc  cacctttta  agaaaggaa  cgttcactc  ggaggccta  1560
tatagttct  ctcaggatt  gccctatcc  gatcctgct  tagctcagt  ttcagttca  1620
aaagtcact  cacagtctg  tggctccag  tcaaaagtg  aagtcaagg  ccgggtaaa  1680
gtgcatggc  ttttcagtg  gtccagtgc  gccttagta  aggtgcaca  gtccgagga  1740
agcgaggag  caatggaga  tgatcagaa  gcaaaggaa  aagagaaga  gcaggtgga  1800
caggaagaa  cacatactg  agagcaaca  ccacagaca  cagcagaaa  caaggcgga  1860
tctgaggag  tggagacct  tcaagctgg  tcaaaagat  aaaagatgg  ccaaccacc  1920
caagcaaag  aggcaaaag  gaagaccag  accgtggac  tgcccattg  gagccagct  1980
ctgtggcag  tggaccggg  aatgctcgg  ctgtacaca  agaatgagg  taagatgat  2040
atgcaggat  aactggaga  ggaacggaa  gacgccaaa  atgcggtgg  agagtatgt  2100
tatgagatg  gagacaaac  tagtggtga  tatgagaag  ttgtgagtg  agatgatcg  2160
aataatttt  ctttgaaat  agaggatac  gaaaactgg  tgtatgaag  tggagaaga  2220
caaccaaag  aagtttatg  agacaaatt  gctgagtta  gaactttag  tcaacctat  2280
aagacacgg  tccaggaat  tgaagaaag  ccaaaatta  ttgaagaat  agggaagca  2340
atccaacag  atatgaaag  gatcagctc  ttcaaaaac  aggaggacc  gtatgaaca  2400
ttggatgct  ctgacatga  aaaggtaga  aaaagcacc  atgaggcga  ggagtggat  2460
aatagtaag  tgaacctgc  gaacaaaca  agcctgacg  cggatccag  tgtcaagac  2520
aaagagatt  aagctaaaa  taaggagct  acaaatatt  gcagtccta  aatttcaaa  2580
cccaaaccc  aagtggaac  ccctaagga  gaaccaaaa  atgctgagc  gaatggacc  2640
gtggatggc  aaggagaca  cccaggcac  caagctgct  agcacggtg  agacacagc  2700
gtgccttct  atggtgaca  gaagcttcc  gagatggac  ttgattgat  ccaacactt  2760
tttatatta  aacagacta  tataaagct  taagttgtc  actttgttc  gaatatcaa  2820
tagagcaag  aaatactgg  gatttctta  tcagttttt  ggggatctc  gggtggggt  2880
tataggtaa  atacagagc  ttttgactt  taaatagtt  gatccagag  tgaagtgca  2940
tgttctctc  tcattatga  cctgtttaa  agcccagct  gtctttctg  gctcttgcc  3000
ccctccttg  tttaatcat  cttctacaa  gtgaagtgt  tttggggaa  ctgagctct  3060
acaaaagct  tgagagcca  taggcaggc  tttcctcaa  catgacaga  gttcaaatt  3120
tgcttggaa  ggctgagtg  agatcacca  cagcattct  tgcctgtgg  gctgtggga  3180
tgtggggct  gtgcttcct  catttctga  ggtctgaga  tggcccagc  tgcattaac  3240
caggagagc  cagagcgca  cagggcctg  tctcattgc  ctctattcc  agccctgtc  3300
tcctcttcc  tccgcaagc  gtataaatg  catgtgccc  ctgcactta  agtgagcct  3360
agcgtatca  ggggctttg  cgtggctcc  cgtacttcc  gaaagtatt  actgacact  3420
aagcgtcag  gtctagtgt  accttaagg  aggttgtaa  taacagttg  ctgtaggca  3480
ggtaagtct  agcagccca  ccttagtgt  gtgggaagg  ctgtaccct  acctgctcc  3540
cggtagatg  tgtatgtaa  ttagaggtt  cgatggaac  ggatgagag  tcaaggttc  3600
ttgtttggt  ttatttgtg  taatgtgtc  tgaatctgc  aatctgtat  ttaaaacag  3660
tgacagatt  taaagctat  gccctggac  agtctgaaa  tagtgtaaa  gaaaacctc  3720
tcgttaact  cagccgctg  cagggtacc  tatattcct  gaacaagtc  atggggaag  3780
gatgttctg  agacaaagg  acggatgcc  atggtagag  tcagagttg  ttacctgcc  3840
tagttacaa  tgttacgtt  tgggtcttt  taatcactg  tctctgtaa  agagcctct  3900
tttattctt  cttgttgga  ataagctta  accatgcat  gttagaatt  ctatgcttc  3960
gtctacaca  gaagtgctg  agctctcaa  tgctctaga  gccattggt  ggagaggaa  4020
gaatgcatg  ttatgttat  taagcaact  gactcccgc  cagtacagg  ctggagctc  4080
aggccgagt  catactctg  tgctttgag  gctgcagga  tgcccactg  cctggctgt  4140
aggctgata  ctttttcaa  tgcaggctg  aggattaag  caactctta  gcaactgac  4200
gtccttaat  atgatctca  aaacatttg  gtgtggggg  gggagggtt  gggtgtcgg  4260
atggggaat  aatttgaag  ctaaagtta  agctagaaa  cagatgatc  gcttctgct  4320
tgtctatat  gacgattgg  tttatgtgg  ggcaggcca  atggcaact  atgacttgt  4380
tgcaaacaa  catttatcc  ggttgcaat  tccaaattg  tttgttaaa  actctaggt  4440
acattctta  actaagaaa  acagtaaac  tgagacaaa  tttaggaaa  actaataaa  4500
gaaacctgt  ttaacttga  a  4521



<210> 1087
<211> 999
<212> PRT
<213> Rattus norvegicus
<308> Q63617
<400> 1087

Met Ala Ala Thr Val Arg Arg Gln Arg Pro Arg Arg Leu Leu Cys Trp 
  1               5                  10                  15
Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
             20                  25                  30
Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
         35                  40                  45
Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
     50                  55                  60
Arg Arg Lys Thr Pro Val Thr Val Thr Leu Lys Glu Asn Glu Arg Phe 
 65                  70                  75                  80
Leu Gly Asp Ser Ala Ala Gly Met Ala Ile Lys Asn Pro Lys Ala Thr 
                 85                  90                  95
Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
             100                105                110
Val Ala Leu Tyr Arg Ser Arg Phe Pro Glu His Glu Leu Asn Val Asp 
         115                120                125
Pro Gln Arg Gln Thr Val Arg Phe Gln Ile Ser Pro Gln Leu Gln Phe 
     130                135                140
Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
 145                150                155                160
Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                 165                170                175
Pro Ala Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
             180                185                190
Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
         195                200                205
Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Ser Thr 
     210                215                220
Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
 225                230                235                240
Thr Ile Val Thr Tyr Gln Thr Val Lys Thr Lys Glu Ala Gly Thr Gln 
                 245                250                255
Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
             260                265                270
Leu Glu Met Glu Leu Arg Leu Arg Glu His Leu Ala Lys Leu Phe Asn 
         275                280                285
Glu Gln Arg Lys Gly Gln Lys Ala Lys Asp Val Arg Glu Asn Pro Arg 
     290                295                300
Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
 305                310                315                320
Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                 325                330                335
Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
             340                345                350
Ala Asp Leu Phe Asp Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
         355                360                365
Ser Ala Glu Met Ser Leu Asp Gln Ile Glu Gln Val Ile Leu Val Gly 
     370                375                380
Gly Pro Thr Arg Val Pro Lys Val Gln Glu Val Leu Leu Lys Pro Val 
 385                390                395                400
Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                 405                410                415
Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
             420                425                430
Lys Pro Phe Val Val Arg Asp Ala Val Ile Tyr Pro Ile Leu Val Glu 
         435                440                445
Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Leu Arg Ser Leu Lys His 
     450                455                460
Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
 465                470                475                480
Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                 485                490                495
Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
             500                505                510
Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Glu Ser Phe 
         515                520                525
Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
     530                535                540
Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
 545                550                555                560
Glu Thr Leu Val Glu Asp Ser Pro Glu Glu Glu Ser Thr Leu Thr Lys 
                 565                570                575
Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Ser Ser Asp 
             580                585                590
Ala Lys Glu Asn Gly Thr Asp Ala Val Gln Glu Glu Glu Glu Ser Pro 
         595                600                605
Ala Glu Gly Ser Lys Asp Glu Pro Ala Glu Gln Gly Glu Leu Lys Glu 
     610                615                620
Glu Ala Glu Ala Pro Met Glu Asp Thr Ser Gln Pro Pro Pro Ser Glu 
 625                630                635                640
Pro Lys Gly Asp Ala Ala Arg Glu Gly Glu Thr Pro Asp Glu Lys Glu 
                 645                650                655
Ser Gly Asp Lys Ser Glu Ala Gln Lys Pro Asn Glu Lys Gly Gln Ala 
             660                665                670
Gly Pro Glu Gly Val Pro Pro Ala Pro Glu Glu Glu Lys Lys Gln Lys 
         675                680                685
Pro Ala Arg Lys Gln Lys Met Val Glu Glu Ile Gly Val Glu Leu Ala 
     690                695                700
Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Glu Leu Ala His Ser Val 
 705                710                715                720
Gln Lys Leu Glu Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg 
                 725                730                735
Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp 
             740                745                750
Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg 
         755                760                765
Glu Glu Ile Ser Gly Lys Leu Ser Ala Thr Ser Thr Trp Leu Glu Asp 
     770                775                780
Glu Gly Phe Gly Ala Thr Thr Val Met Leu Lys Asp Lys Leu Ala Glu 
 785                790                795                800
Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Arg 
                 805                810                815
Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser 
             820                825                830
Ser Ile Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile 
         835                840                845
Phe Thr Asp Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Asp Thr 
     850                855                860
Trp Thr Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala 
 865                870                875                880
Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met 
                 885                890                895
Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr 
             900                905                910
Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Thr Glu Pro 
         915                920                925
Pro Leu Asn Ala Ser Ala Gly Asp Gln Glu Glu Lys Val Ile Pro Pro 
     930                935                940
Thr Gly Gln Thr Glu Glu Ala Lys Ala Ile Leu Glu Pro Asp Lys Glu 
 945                950                955                960
Gly Leu Gly Thr Glu Ala Ala Asp Ser Glu Pro Leu Glu Leu Gly Gly 
                 965                970                975
Pro Gly Ala Glu Ser Glu Gln Ala Glu Gln Thr Ala Gly Gln Lys Arg 
             980                985                990
Pro Leu Lys Asn Asp Glu Leu 
         995



<210> 1088
<211> 715
<212> DNA
<213> Homo sapiens
<308> BC002526
<400> 1088

ggcacgagg  gccactgag  cggagccgg  ctgagcagc  ctctcggtt  cagtaccca  60
tggaaggac  taggcgctc  cgtggacac  gcaagcccc  cagtagcct  ggcccaaga  120
gcctgcttt  cactcgcta  ccccgccgg  ggtccgtgt  ctgtctcgg  ggccggacc  180
gggcccgag  ccgagcagt  gccggcgcc  tgtcggtgg  gggcataga  ctgggcttc  240
agagctgct  cgtcgctgt  gcccgcgcc  gcggcatcg  gactatcgc  aatgagtat  300
gcgaccgct  cacgccggc  tgcatttct  ttggtccta  gaatcgttc  attggagca  360
cagctaaaa  ccaggtaat  tctaatgca  agaacacag  ccaaggatt  aaaagattc  420
atggccgag  attctctga  ccatttgtg  aggcagaaa  atctaacct  gcatatgat  480
ttgtgcagt  gcctacagg  ttaacaggt  taaaggtga  atatatgga  gaagagcag  540
atggaccag  ggatggaca  ggagacaac  caggccccc  ggctgctga  cagggtaca  600
acacagctg  gccttcgga  tcagacaag  agcttcctg  aatggacat  gattgattc  660
aacacttgt  tctattaaa  cagactatt  taaaaaaaa  aaaaaaaaa  aaaaa  715



<210> 1089
<211> 840
<212> PRT
<213> Homo sapiens
<308> P34932
<400> 1089

Met Ser Val Val Gly Ile Asp Leu Gly Phe Gln Ser Cys Tyr Val Ala 
  1               5                  10                  15
Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Tyr Ser Asp 
             20                  25                  30
Arg Cys Thr Pro Ala Cys Ile Ser Phe Gly Pro Lys Asn Arg Ser Ile 
         35                  40                  45
Gly Ala Ala Ala Lys Ser Gln Val Ile Ser Asn Ala Lys Asn Thr Val 
     50                  55                  60
Gln Gly Phe Lys Arg Phe His Gly Arg Ala Phe Ser Asp Pro Phe Val 
 65                  70                  75                  80
Glu Ala Glu Lys Ser Asn Leu Ala Tyr Asp Ile Val Gln Leu Pro Thr 
                 85                  90                  95
Gly Leu Thr Gly Ile Lys Val Thr Tyr Met Glu Glu Glu Arg Asn Phe 
             100                105                110
Thr Thr Glu Gln Val Thr Ala Met Leu Leu Ser Lys Leu Lys Glu Thr 
         115                120                125
Ala Glu Ser Val Leu Lys Lys Pro Val Val Asp Cys Val Val Ser Val 
     130                135                140
Pro Cys Phe Tyr Thr Asp Ala Glu Arg Arg Ser Val Met Asp Ala Thr 
 145                150                155                160
Gln Ile Ala Gly Leu Asn Cys Leu Arg Leu Met Asn Glu Thr Thr Ala 
                 165                170                175
Val Ala Leu Ala Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ala Leu Glu 
             180                185                190
Glu Lys Pro Arg Asn Val Val Phe Val Asp Met Gly His Ser Ala Tyr 
         195                200                205
Gln Val Ser Val Cys Ala Phe Asn Arg Gly Lys Leu Lys Val Leu Ala 
     210                215                220
Thr Ala Phe Asp Thr Thr Leu Gly Gly Arg Lys Phe Asp Glu Val Leu 
 225                230                235                240
Val Asn His Phe Cys Glu Glu Phe Gly Lys Lys Tyr Lys Leu Asp Ile 
                 245                250                255
Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Ser Gln Glu Cys Glu Lys 
             260                265                270
Leu Lys Lys Leu Met Ser Ala Asn Ala Ser Asp Leu Pro Leu Ser Ile 
         275                280                285
Glu Cys Phe Met Asn Asp Val Asp Val Ser Gly Thr Met Asn Arg Gly 
     290                295                300
Lys Phe Leu Glu Met Cys Asn Asp Leu Leu Ala Arg Val Glu Pro Pro 
 305                310                315                320
Leu Arg Ser Val Leu Glu Gln Thr Lys Leu Lys Lys Glu Asp Ile Tyr 
                 325                330                335
Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
             340                345                350
Lys Ile Ser Lys Phe Phe Gly Lys Glu Leu Ser Thr Thr Leu Asn Ala 
         355                360                365
Asp Glu Ala Val Thr Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
     370                375                380
Pro Ala Phe Lys Val Arg Glu Phe Ser Ile Thr Asp Val Val Pro Tyr 
 385                390                395                400
Pro Ile Ser Leu Arg Trp Asn Ser Pro Ala Glu Glu Gly Ser Ser Asp 
                 405                410                415
Cys Glu Val Phe Ser Lys Asn His Ala Ala Pro Phe Ser Lys Val Leu 
             420                425                430
Thr Phe Tyr Arg Lys Glu Pro Phe Thr Leu Glu Ala Tyr Tyr Ser Ser 
         435                440                445
Pro Gln Asp Leu Pro Tyr Pro Asp Pro Ala Ile Ala Gln Phe Ser Val 
     450                455                460
Gln Lys Val Thr Pro Gln Ser Asp Gly Ser Ser Ser Lys Val Lys Val 
 465                470                475                480
Lys Val Arg Val Asn Val His Gly Ile Phe Ser Val Ser Ser Ala Ser 
                 485                490                495
Leu Val Glu Val His Lys Ser Glu Glu Asn Glu Glu Pro Met Glu Thr 
             500                505                510
Asp Gln Asn Ala Lys Glu Glu Glu Lys Met Gln Val Asp Gln Glu Glu 
         515                520                525
Pro His Val Glu Glu Gln Gln Gln Gln Thr Pro Ala Glu Asn Lys Ala 
     530                535                540
Glu Ser Glu Glu Met Glu Thr Ser Gln Ala Gly Ser Lys Asp Lys Lys 
 545                550                555                560
Met Asp Gln Pro Pro Gln Ala Lys Lys Ala Lys Val Lys Thr Ser Thr 
                 565                570                575
Val Asp Leu Pro Ile Glu Asn Gln Leu Leu Trp Gln Ile Asp Arg Glu 
             580                585                590
Met Leu Asn Leu Tyr Ile Glu Asn Glu Gly Lys Met Ile Met Gln Asp 
         595                600                605
Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Arg Glu Tyr 
     610                615                620
Val Tyr Glu Met Arg Asp Lys Leu Ser Gly Glu Tyr Glu Lys Phe Val 
 625                630                635                640
Ser Glu Asp Gly Arg Asn Ser Phe Thr Leu Lys Leu Glu Asp Thr Glu 
                 645                650                655
Asn Trp Leu Tyr Glu Asp Gly Glu Asp Gln Pro Lys Gln Val Tyr Val 
             660                665                670
Asp Lys Leu Ala Glu Leu Lys Asn Leu Gly Gln Pro Ile Lys Ile Arg 
         675                680                685
Phe Gln Glu Ser Glu Glu Arg Pro Lys Leu Phe Glu Glu Leu Gly Lys 
     690                695                700
Gln Ile Gln Gln Tyr Met Lys Ile Ile Ser Ser Phe Lys Asn Lys Glu 
 705                710                715                720
Asp Gln Tyr Asp His Leu Asp Ala Ala Asp Met Thr Lys Val Glu Lys 
                 725                730                735
Ser Thr Asn Glu Ala Met Glu Trp Met Asn Asn Lys Leu Asn Leu Gln 
             740                745                750
Asn Lys Gln Ser Leu Thr Met Asp Pro Val Val Lys Ser Lys Glu Ile 
         755                760                765
Glu Ala Lys Ile Lys Glu Leu Thr Ser Thr Cys Ser Pro Ile Ile Ser 
     770                775                780
Lys Pro Lys Pro Lys Val Glu Pro Pro Lys Glu Glu Gln Lys Asn Ala 
 785                790                795                800
Glu Gln Asn Gly Pro Val Asp Gly Gln Gly Asp Asn Pro Gly Pro Gln 
                 805                810                815
Ala Ala Glu Gln Gly Thr Asp Thr Ala Val Pro Ser Asp Ser Asp Lys 
             820                825                830
Lys Leu Pro Glu Met Asp Ile Asp 
         835                840



<210> 1090
<211> 4521
<212> DNA
<213> Rattus norvegicus
<308> AF077354
<400> 1090

cggcgcctc  tctgcggcc  tggagccgg  gccggcctg  gcggtagag  cccgtcttt  60
tcaaggacc  aagcatcct  gtggacggt  gtccggctt  gcccgccca  ccgcggtgc  120
ccatcagcc  acgcggcgc  ccctctcca  gcgccaacc  cgtcgggtt  cgtgtgcag  180
gtcggcggc  ggccctggg  ccgagcccg  gcagtagcc  gcgccatgt  ggtggtggg  240
atagacctg  gctttcaga  ctgctatgt  gctgtggcc  gcgccggcg  cattgagac  300
atcgctaat  agtatagcg  ccgctgcac  ccggcttgt  tttctttcg  tcctaagaa  360
cgttcagtt  gagcagcag  aaagagcca  gtaatttcc  atgccaaga  cacagttca  420
gggtttaaa  gatttcatg  gcgtgcatt  tcagatcca  ttgtggaag  agaaaaatc  480
aaccttgca  atgatattg  acagttgcc  actggatta  cgggcataa  ggttacata  540
atggaagaa  agaggaatt  taccactga  caagtgact  ccatgctct  gtcaaaact  600
aaggagaca  cagaaagtg  tcttaagaa  cctgttgta  actgtgttg  ttcggttcc  660
agtttctac  ctgatgcag  acgacggtc  gtgatggat  ccacacaga  tgctggtct  720
aattgcttg  ggttaatga  tgaaacaac  gcagttgct  ttgcttatg  aatctataa  780
caagacctt  ctgccttag  agaaaaacc  agaaatgta  tttttgtag  tatgggaca  840
tctgcctat  aagtttctg  atgtgcatt  aatagagga  aactgaaag  tttggccac  900
gcttttgat  caacattgg  aggcagaaa  tttgatgag  tgttggtaa  tcacttctg  960
gaagaattt  gaaagaaat  caagctaga  ataaaatct  aagttcgtg  tttattgcg  1020
ctctctcaa  agtgtgaga  actcaagaa  ttaatgagt  cgaatgctt  agacctccc  1080
ttgagtatt  aatgcttta  gaacgatat  gatgtatcg  gaaccatga  tagaggcaa  1140
tttttggag  tgtgtgatg  tctcttagc  agagtggag  cgccacttc  tagcatctt  1200
gaccaatcc  agttaaaga  agaagatat  tatgcagtg  agatagttg  tggagccac  1260
cggatccct  ccgtgaaag  gaagatcag  aagttcttt  gtaaagaac  cagcacaac  1320
ttaaatgcg  atgaagcag  cactcgagg  tgtgctctg  agtgtgcaa  cttatcacc  1380
gctttcaaa  tcagagaat  ttctatcac  gatgtggta  catatccaa  atctttgag  1440
tggaattct  cagctgaag  ggggtcaag  gactgtgaa  tcttcccca  aaaccatgc  1500
gctcctttc  ccaaagtcc  cacctttta  agaaaggaa  cgttcactc  ggaggccta  1560
tatagttct  ctcaggatt  gccctatcc  gatcctgct  tagctcagt  ttcagttca  1620
aaagtcact  cacagtctg  tggctccag  tcaaaagtg  aagtcaagg  ccgggtaaa  1680
gtgcatggc  ttttcagtg  gtccagtgc  gccttagta  aggtgcaca  gtccgagga  1740
agcgaggag  caatggaga  tgatcagaa  gcaaaggaa  aagagaaga  gcaggtgga  1800
caggaagaa  cacatactg  agagcaaca  ccacagaca  cagcagaaa  caaggcgga  1860
tctgaggag  tggagacct  tcaagctgg  tcaaaagat  aaaagatgg  ccaaccacc  1920
caagcaaag  aggcaaaag  gaagaccag  accgtggac  tgcccattg  gagccagct  1980
ctgtggcag  tggaccggg  aatgctcgg  ctgtacaca  agaatgagg  taagatgat  2040
atgcaggat  aactggaga  ggaacggaa  gacgccaaa  atgcggtgg  agagtatgt  2100
tatgagatg  gagacaaac  tagtggtga  tatgagaag  ttgtgagtg  agatgatcg  2160
aataatttt  ctttgaaat  agaggatac  gaaaactgg  tgtatgaag  tggagaaga  2220
caaccaaag  aagtttatg  agacaaatt  gctgagtta  gaactttag  tcaacctat  2280
aagacacgg  tccaggaat  tgaagaaag  ccaaaatta  ttgaagaat  agggaagca  2340
atccaacag  atatgaaag  gatcagctc  ttcaaaaac  aggaggacc  gtatgaaca  2400
ttggatgct  ctgacatga  aaaggtaga  aaaagcacc  atgaggcga  ggagtggat  2460
aatagtaag  tgaacctgc  gaacaaaca  agcctgacg  cggatccag  tgtcaagac  2520
aaagagatt  aagctaaaa  taaggagct  acaaatatt  gcagtccta  aatttcaaa  2580
cccaaaccc  aagtggaac  ccctaagga  gaaccaaaa  atgctgagc  gaatggacc  2640
gtggatggc  aaggagaca  cccaggcac  caagctgct  agcacggtg  agacacagc  2700
gtgccttct  atggtgaca  gaagcttcc  gagatggac  ttgattgat  ccaacactt  2760
tttatatta  aacagacta  tataaagct  taagttgtc  actttgttc  gaatatcaa  2820
tagagcaag  aaatactgg  gatttctta  tcagttttt  ggggatctc  gggtggggt  2880
tataggtaa  atacagagc  ttttgactt  taaatagtt  gatccagag  tgaagtgca  2940
tgttctctc  tcattatga  cctgtttaa  agcccagct  gtctttctg  gctcttgcc  3000
ccctccttg  tttaatcat  cttctacaa  gtgaagtgt  tttggggaa  ctgagctct  3060
acaaaagct  tgagagcca  taggcaggc  tttcctcaa  catgacaga  gttcaaatt  3120
tgcttggaa  ggctgagtg  agatcacca  cagcattct  tgcctgtgg  gctgtggga  3180
tgtggggct  gtgcttcct  catttctga  ggtctgaga  tggcccagc  tgcattaac  3240
caggagagc  cagagcgca  cagggcctg  tctcattgc  ctctattcc  agccctgtc  3300
tcctcttcc  tccgcaagc  gtataaatg  catgtgccc  ctgcactta  agtgagcct  3360
agcgtatca  ggggctttg  cgtggctcc  cgtacttcc  gaaagtatt  actgacact  3420
aagcgtcag  gtctagtgt  accttaagg  aggttgtaa  taacagttg  ctgtaggca  3480
ggtaagtct  agcagccca  ccttagtgt  gtgggaagg  ctgtaccct  acctgctcc  3540
cggtagatg  tgtatgtaa  ttagaggtt  cgatggaac  ggatgagag  tcaaggttc  3600
ttgtttggt  ttatttgtg  taatgtgtc  tgaatctgc  aatctgtat  ttaaaacag  3660
tgacagatt  taaagctat  gccctggac  agtctgaaa  tagtgtaaa  gaaaacctc  3720
tcgttaact  cagccgctg  cagggtacc  tatattcct  gaacaagtc  atggggaag  3780
gatgttctg  agacaaagg  acggatgcc  atggtagag  tcagagttg  ttacctgcc  3840
tagttacaa  tgttacgtt  tgggtcttt  taatcactg  tctctgtaa  agagcctct  3900
tttattctt  cttgttgga  ataagctta  accatgcat  gttagaatt  ctatgcttc  3960
gtctacaca  gaagtgctg  agctctcaa  tgctctaga  gccattggt  ggagaggaa  4020
gaatgcatg  ttatgttat  taagcaact  gactcccgc  cagtacagg  ctggagctc  4080
aggccgagt  catactctg  tgctttgag  gctgcagga  tgcccactg  cctggctgt  4140
aggctgata  ctttttcaa  tgcaggctg  aggattaag  caactctta  gcaactgac  4200
gtccttaat  atgatctca  aaacatttg  gtgtggggg  gggagggtt  gggtgtcgg  4260
atggggaat  aatttgaag  ctaaagtta  agctagaaa  cagatgatc  gcttctgct  4320
tgtctatat  gacgattgg  tttatgtgg  ggcaggcca  atggcaact  atgacttgt  4380
tgcaaacaa  catttatcc  ggttgcaat  tccaaattg  tttgttaaa  actctaggt  4440
acattctta  actaagaaa  acagtaaac  tgagacaaa  tttaggaaa  actaataaa  4500
gaaacctgt  ttaacttga  a  4521



<210> 1091
<211> 999
<212> PRT
<213> Rattus norvegicus
<308> Q63617
<400> 1091

Met Ala Ala Thr Val Arg Arg Gln Arg Pro Arg Arg Leu Leu Cys Trp 
  1               5                  10                  15
Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
             20                  25                  30
Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
         35                  40                  45
Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
     50                  55                  60
Arg Arg Lys Thr Pro Val Thr Val Thr Leu Lys Glu Asn Glu Arg Phe 
 65                  70                  75                  80
Leu Gly Asp Ser Ala Ala Gly Met Ala Ile Lys Asn Pro Lys Ala Thr 
                 85                  90                  95
Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
             100                105                110
Val Ala Leu Tyr Arg Ser Arg Phe Pro Glu His Glu Leu Asn Val Asp 
         115                120                125
Pro Gln Arg Gln Thr Val Arg Phe Gln Ile Ser Pro Gln Leu Gln Phe 
     130                135                140
Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
 145                150                155                160
Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                 165                170                175
Pro Ala Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
             180                185                190
Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
         195                200                205
Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Ser Thr 
     210                215                220
Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
 225                230                235                240
Thr Ile Val Thr Tyr Gln Thr Val Lys Thr Lys Glu Ala Gly Thr Gln 
                 245                250                255
Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
             260                265                270
Leu Glu Met Glu Leu Arg Leu Arg Glu His Leu Ala Lys Leu Phe Asn 
         275                280                285
Glu Gln Arg Lys Gly Gln Lys Ala Lys Asp Val Arg Glu Asn Pro Arg 
     290                295                300
Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
 305                310                315                320
Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                 325                330                335
Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
             340                345                350
Ala Asp Leu Phe Asp Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
         355                360                365
Ser Ala Glu Met Ser Leu Asp Gln Ile Glu Gln Val Ile Leu Val Gly 
     370                375                380
Gly Pro Thr Arg Val Pro Lys Val Gln Glu Val Leu Leu Lys Pro Val 
 385                390                395                400
Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                 405                410                415
Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
             420                425                430
Lys Pro Phe Val Val Arg Asp Ala Val Ile Tyr Pro Ile Leu Val Glu 
         435                440                445
Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Leu Arg Ser Leu Lys His 
     450                455                460
Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
 465                470                475                480
Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                 485                490                495
Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
             500                505                510
Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Glu Ser Phe 
         515                520                525
Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
     530                535                540
Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
 545                550                555                560
Glu Thr Leu Val Glu Asp Ser Pro Glu Glu Glu Ser Thr Leu Thr Lys 
                 565                570                575
Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Ser Ser Asp 
             580                585                590
Ala Lys Glu Asn Gly Thr Asp Ala Val Gln Glu Glu Glu Glu Ser Pro 
         595                600                605
Ala Glu Gly Ser Lys Asp Glu Pro Ala Glu Gln Gly Glu Leu Lys Glu 
     610                615                620
Glu Ala Glu Ala Pro Met Glu Asp Thr Ser Gln Pro Pro Pro Ser Glu 
 625                630                635                640
Pro Lys Gly Asp Ala Ala Arg Glu Gly Glu Thr Pro Asp Glu Lys Glu 
                 645                650                655
Ser Gly Asp Lys Ser Glu Ala Gln Lys Pro Asn Glu Lys Gly Gln Ala 
             660                665                670
Gly Pro Glu Gly Val Pro Pro Ala Pro Glu Glu Glu Lys Lys Gln Lys 
         675                680                685
Pro Ala Arg Lys Gln Lys Met Val Glu Glu Ile Gly Val Glu Leu Ala 
     690                695                700
Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Glu Leu Ala His Ser Val 
 705                710                715                720
Gln Lys Leu Glu Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg 
                 725                730                735
Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp 
             740                745                750
Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg 
         755                760                765
Glu Glu Ile Ser Gly Lys Leu Ser Ala Thr Ser Thr Trp Leu Glu Asp 
     770                775                780
Glu Gly Phe Gly Ala Thr Thr Val Met Leu Lys Asp Lys Leu Ala Glu 
 785                790                795                800
Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Arg 
                 805                810                815
Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser 
             820                825                830
Ser Ile Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile 
         835                840                845
Phe Thr Asp Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Asp Thr 
     850                855                860
Trp Thr Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala 
 865                870                875                880
Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met 
                 885                890                895
Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr 
             900                905                910
Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Thr Glu Pro 
         915                920                925
Pro Leu Asn Ala Ser Ala Gly Asp Gln Glu Glu Lys Val Ile Pro Pro 
     930                935                940
Thr Gly Gln Thr Glu Glu Ala Lys Ala Ile Leu Glu Pro Asp Lys Glu 
 945                950                955                960
Gly Leu Gly Thr Glu Ala Ala Asp Ser Glu Pro Leu Glu Leu Gly Gly 
                 965                970                975
Pro Gly Ala Glu Ser Glu Gln Ala Glu Gln Thr Ala Gly Gln Lys Arg 
             980                985                990
Pro Leu Lys Asn Asp Glu Leu 
         995



<210> 1092
<211> 715
<212> DNA
<213> Homo sapiens
<308> BC002526
<400> 1092

ggcacgagg  gccactgag  cggagccgg  ctgagcagc  ctctcggtt  cagtaccca  60
tggaaggac  taggcgctc  cgtggacac  gcaagcccc  cagtagcct  ggcccaaga  120
gcctgcttt  cactcgcta  ccccgccgg  ggtccgtgt  ctgtctcgg  ggccggacc  180
gggcccgag  ccgagcagt  gccggcgcc  tgtcggtgg  gggcataga  ctgggcttc  240
agagctgct  cgtcgctgt  gcccgcgcc  gcggcatcg  gactatcgc  aatgagtat  300
gcgaccgct  cacgccggc  tgcatttct  ttggtccta  gaatcgttc  attggagca  360
cagctaaaa  ccaggtaat  tctaatgca  agaacacag  ccaaggatt  aaaagattc  420
atggccgag  attctctga  ccatttgtg  aggcagaaa  atctaacct  gcatatgat  480
ttgtgcagt  gcctacagg  ttaacaggt  taaaggtga  atatatgga  gaagagcag  540
atggaccag  ggatggaca  ggagacaac  caggccccc  ggctgctga  cagggtaca  600
acacagctg  gccttcgga  tcagacaag  agcttcctg  aatggacat  gattgattc  660
aacacttgt  tctattaaa  cagactatt  taaaaaaaa  aaaaaaaaa  aaaaa  715



<210> 1093
<211> 840
<212> PRT
<213> Homo sapiens
<308> P34932
<400> 1093

Met Ser Val Val Gly Ile Asp Leu Gly Phe Gln Ser Cys Tyr Val Ala 
  1               5                  10                  15
Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Tyr Ser Asp 
             20                  25                  30
Arg Cys Thr Pro Ala Cys Ile Ser Phe Gly Pro Lys Asn Arg Ser Ile 
         35                  40                  45
Gly Ala Ala Ala Lys Ser Gln Val Ile Ser Asn Ala Lys Asn Thr Val 
     50                  55                  60
Gln Gly Phe Lys Arg Phe His Gly Arg Ala Phe Ser Asp Pro Phe Val 
 65                  70                  75                  80
Glu Ala Glu Lys Ser Asn Leu Ala Tyr Asp Ile Val Gln Leu Pro Thr 
                 85                  90                  95
Gly Leu Thr Gly Ile Lys Val Thr Tyr Met Glu Glu Glu Arg Asn Phe 
             100                105                110
Thr Thr Glu Gln Val Thr Ala Met Leu Leu Ser Lys Leu Lys Glu Thr 
         115                120                125
Ala Glu Ser Val Leu Lys Lys Pro Val Val Asp Cys Val Val Ser Val 
     130                135                140
Pro Cys Phe Tyr Thr Asp Ala Glu Arg Arg Ser Val Met Asp Ala Thr 
 145                150                155                160
Gln Ile Ala Gly Leu Asn Cys Leu Arg Leu Met Asn Glu Thr Thr Ala 
                 165                170                175
Val Ala Leu Ala Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ala Leu Glu 
             180                185                190
Glu Lys Pro Arg Asn Val Val Phe Val Asp Met Gly His Ser Ala Tyr 
         195                200                205
Gln Val Ser Val Cys Ala Phe Asn Arg Gly Lys Leu Lys Val Leu Ala 
     210                215                220
Thr Ala Phe Asp Thr Thr Leu Gly Gly Arg Lys Phe Asp Glu Val Leu 
 225                230                235                240
Val Asn His Phe Cys Glu Glu Phe Gly Lys Lys Tyr Lys Leu Asp Ile 
                 245                250                255
Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Ser Gln Glu Cys Glu Lys 
             260                265                270
Leu Lys Lys Leu Met Ser Ala Asn Ala Ser Asp Leu Pro Leu Ser Ile 
         275                280                285
Glu Cys Phe Met Asn Asp Val Asp Val Ser Gly Thr Met Asn Arg Gly 
     290                295                300
Lys Phe Leu Glu Met Cys Asn Asp Leu Leu Ala Arg Val Glu Pro Pro 
 305                310                315                320
Leu Arg Ser Val Leu Glu Gln Thr Lys Leu Lys Lys Glu Asp Ile Tyr 
                 325                330                335
Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
             340                345                350
Lys Ile Ser Lys Phe Phe Gly Lys Glu Leu Ser Thr Thr Leu Asn Ala 
         355                360                365
Asp Glu Ala Val Thr Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
     370                375                380
Pro Ala Phe Lys Val Arg Glu Phe Ser Ile Thr Asp Val Val Pro Tyr 
 385                390                395                400
Pro Ile Ser Leu Arg Trp Asn Ser Pro Ala Glu Glu Gly Ser Ser Asp 
                 405                410                415
Cys Glu Val Phe Ser Lys Asn His Ala Ala Pro Phe Ser Lys Val Leu 
             420                425                430
Thr Phe Tyr Arg Lys Glu Pro Phe Thr Leu Glu Ala Tyr Tyr Ser Ser 
         435                440                445
Pro Gln Asp Leu Pro Tyr Pro Asp Pro Ala Ile Ala Gln Phe Ser Val 
     450                455                460
Gln Lys Val Thr Pro Gln Ser Asp Gly Ser Ser Ser Lys Val Lys Val 
 465                470                475                480
Lys Val Arg Val Asn Val His Gly Ile Phe Ser Val Ser Ser Ala Ser 
                 485                490                495
Leu Val Glu Val His Lys Ser Glu Glu Asn Glu Glu Pro Met Glu Thr 
             500                505                510
Asp Gln Asn Ala Lys Glu Glu Glu Lys Met Gln Val Asp Gln Glu Glu 
         515                520                525
Pro His Val Glu Glu Gln Gln Gln Gln Thr Pro Ala Glu Asn Lys Ala 
     530                535                540
Glu Ser Glu Glu Met Glu Thr Ser Gln Ala Gly Ser Lys Asp Lys Lys 
 545                550                555                560
Met Asp Gln Pro Pro Gln Ala Lys Lys Ala Lys Val Lys Thr Ser Thr 
                 565                570                575
Val Asp Leu Pro Ile Glu Asn Gln Leu Leu Trp Gln Ile Asp Arg Glu 
             580                585                590
Met Leu Asn Leu Tyr Ile Glu Asn Glu Gly Lys Met Ile Met Gln Asp 
         595                600                605
Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Arg Glu Tyr 
     610                615                620
Val Tyr Glu Met Arg Asp Lys Leu Ser Gly Glu Tyr Glu Lys Phe Val 
 625                630                635                640
Ser Glu Asp Gly Arg Asn Ser Phe Thr Leu Lys Leu Glu Asp Thr Glu 
                 645                650                655
Asn Trp Leu Tyr Glu Asp Gly Glu Asp Gln Pro Lys Gln Val Tyr Val 
             660                665                670
Asp Lys Leu Ala Glu Leu Lys Asn Leu Gly Gln Pro Ile Lys Ile Arg 
         675                680                685
Phe Gln Glu Ser Glu Glu Arg Pro Lys Leu Phe Glu Glu Leu Gly Lys 
     690                695                700
Gln Ile Gln Gln Tyr Met Lys Ile Ile Ser Ser Phe Lys Asn Lys Glu 
 705                710                715                720
Asp Gln Tyr Asp His Leu Asp Ala Ala Asp Met Thr Lys Val Glu Lys 
                 725                730                735
Ser Thr Asn Glu Ala Met Glu Trp Met Asn Asn Lys Leu Asn Leu Gln 
             740                745                750
Asn Lys Gln Ser Leu Thr Met Asp Pro Val Val Lys Ser Lys Glu Ile 
         755                760                765
Glu Ala Lys Ile Lys Glu Leu Thr Ser Thr Cys Ser Pro Ile Ile Ser 
     770                775                780
Lys Pro Lys Pro Lys Val Glu Pro Pro Lys Glu Glu Gln Lys Asn Ala 
 785                790                795                800
Glu Gln Asn Gly Pro Val Asp Gly Gln Gly Asp Asn Pro Gly Pro Gln 
                 805                810                815
Ala Ala Glu Gln Gly Thr Asp Thr Ala Val Pro Ser Asp Ser Asp Lys 
             820                825                830
Lys Leu Pro Glu Met Asp Ile Asp 
         835                840



<210> 1094
<211> 4521
<212> DNA
<213> Rattus norvegicus
<308> AF077354
<400> 1094

cggcgcctc  tctgcggcc  tggagccgg  gccggcctg  gcggtagag  cccgtcttt  60
tcaaggacc  aagcatcct  gtggacggt  gtccggctt  gcccgccca  ccgcggtgc  120
ccatcagcc  acgcggcgc  ccctctcca  gcgccaacc  cgtcgggtt  cgtgtgcag  180
gtcggcggc  ggccctggg  ccgagcccg  gcagtagcc  gcgccatgt  ggtggtggg  240
atagacctg  gctttcaga  ctgctatgt  gctgtggcc  gcgccggcg  cattgagac  300
atcgctaat  agtatagcg  ccgctgcac  ccggcttgt  tttctttcg  tcctaagaa  360
cgttcagtt  gagcagcag  aaagagcca  gtaatttcc  atgccaaga  cacagttca  420
gggtttaaa  gatttcatg  gcgtgcatt  tcagatcca  ttgtggaag  agaaaaatc  480
aaccttgca  atgatattg  acagttgcc  actggatta  cgggcataa  ggttacata  540
atggaagaa  agaggaatt  taccactga  caagtgact  ccatgctct  gtcaaaact  600
aaggagaca  cagaaagtg  tcttaagaa  cctgttgta  actgtgttg  ttcggttcc  660
agtttctac  ctgatgcag  acgacggtc  gtgatggat  ccacacaga  tgctggtct  720
aattgcttg  ggttaatga  tgaaacaac  gcagttgct  ttgcttatg  aatctataa  780
caagacctt  ctgccttag  agaaaaacc  agaaatgta  tttttgtag  tatgggaca  840
tctgcctat  aagtttctg  atgtgcatt  aatagagga  aactgaaag  tttggccac  900
gcttttgat  caacattgg  aggcagaaa  tttgatgag  tgttggtaa  tcacttctg  960
gaagaattt  gaaagaaat  caagctaga  ataaaatct  aagttcgtg  tttattgcg  1020
ctctctcaa  agtgtgaga  actcaagaa  ttaatgagt  cgaatgctt  agacctccc  1080
ttgagtatt  aatgcttta  gaacgatat  gatgtatcg  gaaccatga  tagaggcaa  1140
tttttggag  tgtgtgatg  tctcttagc  agagtggag  cgccacttc  tagcatctt  1200
gaccaatcc  agttaaaga  agaagatat  tatgcagtg  agatagttg  tggagccac  1260
cggatccct  ccgtgaaag  gaagatcag  aagttcttt  gtaaagaac  cagcacaac  1320
ttaaatgcg  atgaagcag  cactcgagg  tgtgctctg  agtgtgcaa  cttatcacc  1380
gctttcaaa  tcagagaat  ttctatcac  gatgtggta  catatccaa  atctttgag  1440
tggaattct  cagctgaag  ggggtcaag  gactgtgaa  tcttcccca  aaaccatgc  1500
gctcctttc  ccaaagtcc  cacctttta  agaaaggaa  cgttcactc  ggaggccta  1560
tatagttct  ctcaggatt  gccctatcc  gatcctgct  tagctcagt  ttcagttca  1620
aaagtcact  cacagtctg  tggctccag  tcaaaagtg  aagtcaagg  ccgggtaaa  1680
gtgcatggc  ttttcagtg  gtccagtgc  gccttagta  aggtgcaca  gtccgagga  1740
agcgaggag  caatggaga  tgatcagaa  gcaaaggaa  aagagaaga  gcaggtgga  1800
caggaagaa  cacatactg  agagcaaca  ccacagaca  cagcagaaa  caaggcgga  1860
tctgaggag  tggagacct  tcaagctgg  tcaaaagat  aaaagatgg  ccaaccacc  1920
caagcaaag  aggcaaaag  gaagaccag  accgtggac  tgcccattg  gagccagct  1980
ctgtggcag  tggaccggg  aatgctcgg  ctgtacaca  agaatgagg  taagatgat  2040
atgcaggat  aactggaga  ggaacggaa  gacgccaaa  atgcggtgg  agagtatgt  2100
tatgagatg  gagacaaac  tagtggtga  tatgagaag  ttgtgagtg  agatgatcg  2160
aataatttt  ctttgaaat  agaggatac  gaaaactgg  tgtatgaag  tggagaaga  2220
caaccaaag  aagtttatg  agacaaatt  gctgagtta  gaactttag  tcaacctat  2280
aagacacgg  tccaggaat  tgaagaaag  ccaaaatta  ttgaagaat  agggaagca  2340
atccaacag  atatgaaag  gatcagctc  ttcaaaaac  aggaggacc  gtatgaaca  2400
ttggatgct  ctgacatga  aaaggtaga  aaaagcacc  atgaggcga  ggagtggat  2460
aatagtaag  tgaacctgc  gaacaaaca  agcctgacg  cggatccag  tgtcaagac  2520
aaagagatt  aagctaaaa  taaggagct  acaaatatt  gcagtccta  aatttcaaa  2580
cccaaaccc  aagtggaac  ccctaagga  gaaccaaaa  atgctgagc  gaatggacc  2640
gtggatggc  aaggagaca  cccaggcac  caagctgct  agcacggtg  agacacagc  2700
gtgccttct  atggtgaca  gaagcttcc  gagatggac  ttgattgat  ccaacactt  2760
tttatatta  aacagacta  tataaagct  taagttgtc  actttgttc  gaatatcaa  2820
tagagcaag  aaatactgg  gatttctta  tcagttttt  ggggatctc  gggtggggt  2880
tataggtaa  atacagagc  ttttgactt  taaatagtt  gatccagag  tgaagtgca  2940
tgttctctc  tcattatga  cctgtttaa  agcccagct  gtctttctg  gctcttgcc  3000
ccctccttg  tttaatcat  cttctacaa  gtgaagtgt  tttggggaa  ctgagctct  3060
acaaaagct  tgagagcca  taggcaggc  tttcctcaa  catgacaga  gttcaaatt  3120
tgcttggaa  ggctgagtg  agatcacca  cagcattct  tgcctgtgg  gctgtggga  3180
tgtggggct  gtgcttcct  catttctga  ggtctgaga  tggcccagc  tgcattaac  3240
caggagagc  cagagcgca  cagggcctg  tctcattgc  ctctattcc  agccctgtc  3300
tcctcttcc  tccgcaagc  gtataaatg  catgtgccc  ctgcactta  agtgagcct  3360
agcgtatca  ggggctttg  cgtggctcc  cgtacttcc  gaaagtatt  actgacact  3420
aagcgtcag  gtctagtgt  accttaagg  aggttgtaa  taacagttg  ctgtaggca  3480
ggtaagtct  agcagccca  ccttagtgt  gtgggaagg  ctgtaccct  acctgctcc  3540
cggtagatg  tgtatgtaa  ttagaggtt  cgatggaac  ggatgagag  tcaaggttc  3600
ttgtttggt  ttatttgtg  taatgtgtc  tgaatctgc  aatctgtat  ttaaaacag  3660
tgacagatt  taaagctat  gccctggac  agtctgaaa  tagtgtaaa  gaaaacctc  3720
tcgttaact  cagccgctg  cagggtacc  tatattcct  gaacaagtc  atggggaag  3780
gatgttctg  agacaaagg  acggatgcc  atggtagag  tcagagttg  ttacctgcc  3840
tagttacaa  tgttacgtt  tgggtcttt  taatcactg  tctctgtaa  agagcctct  3900
tttattctt  cttgttgga  ataagctta  accatgcat  gttagaatt  ctatgcttc  3960
gtctacaca  gaagtgctg  agctctcaa  tgctctaga  gccattggt  ggagaggaa  4020
gaatgcatg  ttatgttat  taagcaact  gactcccgc  cagtacagg  ctggagctc  4080
aggccgagt  catactctg  tgctttgag  gctgcagga  tgcccactg  cctggctgt  4140
aggctgata  ctttttcaa  tgcaggctg  aggattaag  caactctta  gcaactgac  4200
gtccttaat  atgatctca  aaacatttg  gtgtggggg  gggagggtt  gggtgtcgg  4260
atggggaat  aatttgaag  ctaaagtta  agctagaaa  cagatgatc  gcttctgct  4320
tgtctatat  gacgattgg  tttatgtgg  ggcaggcca  atggcaact  atgacttgt  4380
tgcaaacaa  catttatcc  ggttgcaat  tccaaattg  tttgttaaa  actctaggt  4440
acattctta  actaagaaa  acagtaaac  tgagacaaa  tttaggaaa  actaataaa  4500
gaaacctgt  ttaacttga  a  4521



<210> 1095
<211> 999
<212> PRT
<213> Rattus norvegicus
<308> Q63617
<400> 1095

Met Ala Ala Thr Val Arg Arg Gln Arg Pro Arg Arg Leu Leu Cys Trp 
  1               5                  10                  15
Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
             20                  25                  30
Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
         35                  40                  45
Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
     50                  55                  60
Arg Arg Lys Thr Pro Val Thr Val Thr Leu Lys Glu Asn Glu Arg Phe 
 65                  70                  75                  80
Leu Gly Asp Ser Ala Ala Gly Met Ala Ile Lys Asn Pro Lys Ala Thr 
                 85                  90                  95
Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
             100                105                110
Val Ala Leu Tyr Arg Ser Arg Phe Pro Glu His Glu Leu Asn Val Asp 
         115                120                125
Pro Gln Arg Gln Thr Val Arg Phe Gln Ile Ser Pro Gln Leu Gln Phe 
     130                135                140
Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
 145                150                155                160
Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                 165                170                175
Pro Ala Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
             180                185                190
Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
         195                200                205
Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Ser Thr 
     210                215                220
Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
 225                230                235                240
Thr Ile Val Thr Tyr Gln Thr Val Lys Thr Lys Glu Ala Gly Thr Gln 
                 245                250                255
Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
             260                265                270
Leu Glu Met Glu Leu Arg Leu Arg Glu His Leu Ala Lys Leu Phe Asn 
         275                280                285
Glu Gln Arg Lys Gly Gln Lys Ala Lys Asp Val Arg Glu Asn Pro Arg 
     290                295                300
Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
 305                310                315                320
Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                 325                330                335
Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
             340                345                350
Ala Asp Leu Phe Asp Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
         355                360                365
Ser Ala Glu Met Ser Leu Asp Gln Ile Glu Gln Val Ile Leu Val Gly 
     370                375                380
Gly Pro Thr Arg Val Pro Lys Val Gln Glu Val Leu Leu Lys Pro Val 
 385                390                395                400
Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                 405                410                415
Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
             420                425                430
Lys Pro Phe Val Val Arg Asp Ala Val Ile Tyr Pro Ile Leu Val Glu 
         435                440                445
Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Leu Arg Ser Leu Lys His 
     450                455                460
Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
 465                470                475                480
Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                 485                490                495
Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
             500                505                510
Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Glu Ser Phe 
         515                520                525
Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
     530                535                540
Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
 545                550                555                560
Glu Thr Leu Val Glu Asp Ser Pro Glu Glu Glu Ser Thr Leu Thr Lys 
                 565                570                575
Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Ser Ser Asp 
             580                585                590
Ala Lys Glu Asn Gly Thr Asp Ala Val Gln Glu Glu Glu Glu Ser Pro 
         595                600                605
Ala Glu Gly Ser Lys Asp Glu Pro Ala Glu Gln Gly Glu Leu Lys Glu 
     610                615                620
Glu Ala Glu Ala Pro Met Glu Asp Thr Ser Gln Pro Pro Pro Ser Glu 
 625                630                635                640
Pro Lys Gly Asp Ala Ala Arg Glu Gly Glu Thr Pro Asp Glu Lys Glu 
                 645                650                655
Ser Gly Asp Lys Ser Glu Ala Gln Lys Pro Asn Glu Lys Gly Gln Ala 
             660                665                670
Gly Pro Glu Gly Val Pro Pro Ala Pro Glu Glu Glu Lys Lys Gln Lys 
         675                680                685
Pro Ala Arg Lys Gln Lys Met Val Glu Glu Ile Gly Val Glu Leu Ala 
     690                695                700
Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Glu Leu Ala His Ser Val 
 705                710                715                720
Gln Lys Leu Glu Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg 
                 725                730                735
Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp 
             740                745                750
Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg 
         755                760                765
Glu Glu Ile Ser Gly Lys Leu Ser Ala Thr Ser Thr Trp Leu Glu Asp 
     770                775                780
Glu Gly Phe Gly Ala Thr Thr Val Met Leu Lys Asp Lys Leu Ala Glu 
 785                790                795                800
Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Arg 
                 805                810                815
Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser 
             820                825                830
Ser Ile Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile 
         835                840                845
Phe Thr Asp Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Asp Thr 
     850                855                860
Trp Thr Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala 
 865                870                875                880
Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met 
                 885                890                895
Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr 
             900                905                910
Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Thr Glu Pro 
         915                920                925
Pro Leu Asn Ala Ser Ala Gly Asp Gln Glu Glu Lys Val Ile Pro Pro 
     930                935                940
Thr Gly Gln Thr Glu Glu Ala Lys Ala Ile Leu Glu Pro Asp Lys Glu 
 945                950                955                960
Gly Leu Gly Thr Glu Ala Ala Asp Ser Glu Pro Leu Glu Leu Gly Gly 
                 965                970                975
Pro Gly Ala Glu Ser Glu Gln Ala Glu Gln Thr Ala Gly Gln Lys Arg 
             980                985                990
Pro Leu Lys Asn Asp Glu Leu 
         995



<210> 1096
<211> 715
<212> DNA
<213> Homo sapiens
<308> BC002526
<400> 1096

ggcacgagg  gccactgag  cggagccgg  ctgagcagc  ctctcggtt  cagtaccca  60
tggaaggac  taggcgctc  cgtggacac  gcaagcccc  cagtagcct  ggcccaaga  120
gcctgcttt  cactcgcta  ccccgccgg  ggtccgtgt  ctgtctcgg  ggccggacc  180
gggcccgag  ccgagcagt  gccggcgcc  tgtcggtgg  gggcataga  ctgggcttc  240
agagctgct  cgtcgctgt  gcccgcgcc  gcggcatcg  gactatcgc  aatgagtat  300
gcgaccgct  cacgccggc  tgcatttct  ttggtccta  gaatcgttc  attggagca  360
cagctaaaa  ccaggtaat  tctaatgca  agaacacag  ccaaggatt  aaaagattc  420
atggccgag  attctctga  ccatttgtg  aggcagaaa  atctaacct  gcatatgat  480
ttgtgcagt  gcctacagg  ttaacaggt  taaaggtga  atatatgga  gaagagcag  540
atggaccag  ggatggaca  ggagacaac  caggccccc  ggctgctga  cagggtaca  600
acacagctg  gccttcgga  tcagacaag  agcttcctg  aatggacat  gattgattc  660
aacacttgt  tctattaaa  cagactatt  taaaaaaaa  aaaaaaaaa  aaaaa  715



<210> 1097
<211> 840
<212> PRT
<213> Homo sapiens
<308> P34932
<400> 1097

Met Ser Val Val Gly Ile Asp Leu Gly Phe Gln Ser Cys Tyr Val Ala 
  1               5                  10                  15
Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Tyr Ser Asp 
             20                  25                  30
Arg Cys Thr Pro Ala Cys Ile Ser Phe Gly Pro Lys Asn Arg Ser Ile 
         35                  40                  45
Gly Ala Ala Ala Lys Ser Gln Val Ile Ser Asn Ala Lys Asn Thr Val 
     50                  55                  60
Gln Gly Phe Lys Arg Phe His Gly Arg Ala Phe Ser Asp Pro Phe Val 
 65                  70                  75                  80
Glu Ala Glu Lys Ser Asn Leu Ala Tyr Asp Ile Val Gln Leu Pro Thr 
                 85                  90                  95
Gly Leu Thr Gly Ile Lys Val Thr Tyr Met Glu Glu Glu Arg Asn Phe 
             100                105                110
Thr Thr Glu Gln Val Thr Ala Met Leu Leu Ser Lys Leu Lys Glu Thr 
         115                120                125
Ala Glu Ser Val Leu Lys Lys Pro Val Val Asp Cys Val Val Ser Val 
     130                135                140
Pro Cys Phe Tyr Thr Asp Ala Glu Arg Arg Ser Val Met Asp Ala Thr 
 145                150                155                160
Gln Ile Ala Gly Leu Asn Cys Leu Arg Leu Met Asn Glu Thr Thr Ala 
                 165                170                175
Val Ala Leu Ala Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ala Leu Glu 
             180                185                190
Glu Lys Pro Arg Asn Val Val Phe Val Asp Met Gly His Ser Ala Tyr 
         195                200                205
Gln Val Ser Val Cys Ala Phe Asn Arg Gly Lys Leu Lys Val Leu Ala 
     210                215                220
Thr Ala Phe Asp Thr Thr Leu Gly Gly Arg Lys Phe Asp Glu Val Leu 
 225                230                235                240
Val Asn His Phe Cys Glu Glu Phe Gly Lys Lys Tyr Lys Leu Asp Ile 
                 245                250                255
Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Ser Gln Glu Cys Glu Lys 
             260                265                270
Leu Lys Lys Leu Met Ser Ala Asn Ala Ser Asp Leu Pro Leu Ser Ile 
         275                280                285
Glu Cys Phe Met Asn Asp Val Asp Val Ser Gly Thr Met Asn Arg Gly 
     290                295                300
Lys Phe Leu Glu Met Cys Asn Asp Leu Leu Ala Arg Val Glu Pro Pro 
 305                310                315                320
Leu Arg Ser Val Leu Glu Gln Thr Lys Leu Lys Lys Glu Asp Ile Tyr 
                 325                330                335
Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
             340                345                350
Lys Ile Ser Lys Phe Phe Gly Lys Glu Leu Ser Thr Thr Leu Asn Ala 
         355                360                365
Asp Glu Ala Val Thr Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
     370                375                380
Pro Ala Phe Lys Val Arg Glu Phe Ser Ile Thr Asp Val Val Pro Tyr 
 385                390                395                400
Pro Ile Ser Leu Arg Trp Asn Ser Pro Ala Glu Glu Gly Ser Ser Asp 
                 405                410                415
Cys Glu Val Phe Ser Lys Asn His Ala Ala Pro Phe Ser Lys Val Leu 
             420                425                430
Thr Phe Tyr Arg Lys Glu Pro Phe Thr Leu Glu Ala Tyr Tyr Ser Ser 
         435                440                445
Pro Gln Asp Leu Pro Tyr Pro Asp Pro Ala Ile Ala Gln Phe Ser Val 
     450                455                460
Gln Lys Val Thr Pro Gln Ser Asp Gly Ser Ser Ser Lys Val Lys Val 
 465                470                475                480
Lys Val Arg Val Asn Val His Gly Ile Phe Ser Val Ser Ser Ala Ser 
                 485                490                495
Leu Val Glu Val His Lys Ser Glu Glu Asn Glu Glu Pro Met Glu Thr 
             500                505                510
Asp Gln Asn Ala Lys Glu Glu Glu Lys Met Gln Val Asp Gln Glu Glu 
         515                520                525
Pro His Val Glu Glu Gln Gln Gln Gln Thr Pro Ala Glu Asn Lys Ala 
     530                535                540
Glu Ser Glu Glu Met Glu Thr Ser Gln Ala Gly Ser Lys Asp Lys Lys 
 545                550                555                560
Met Asp Gln Pro Pro Gln Ala Lys Lys Ala Lys Val Lys Thr Ser Thr 
                 565                570                575
Val Asp Leu Pro Ile Glu Asn Gln Leu Leu Trp Gln Ile Asp Arg Glu 
             580                585                590
Met Leu Asn Leu Tyr Ile Glu Asn Glu Gly Lys Met Ile Met Gln Asp 
         595                600                605
Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Arg Glu Tyr 
     610                615                620
Val Tyr Glu Met Arg Asp Lys Leu Ser Gly Glu Tyr Glu Lys Phe Val 
 625                630                635                640
Ser Glu Asp Gly Arg Asn Ser Phe Thr Leu Lys Leu Glu Asp Thr Glu 
                 645                650                655
Asn Trp Leu Tyr Glu Asp Gly Glu Asp Gln Pro Lys Gln Val Tyr Val 
             660                665                670
Asp Lys Leu Ala Glu Leu Lys Asn Leu Gly Gln Pro Ile Lys Ile Arg 
         675                680                685
Phe Gln Glu Ser Glu Glu Arg Pro Lys Leu Phe Glu Glu Leu Gly Lys 
     690                695                700
Gln Ile Gln Gln Tyr Met Lys Ile Ile Ser Ser Phe Lys Asn Lys Glu 
 705                710                715                720
Asp Gln Tyr Asp His Leu Asp Ala Ala Asp Met Thr Lys Val Glu Lys 
                 725                730                735
Ser Thr Asn Glu Ala Met Glu Trp Met Asn Asn Lys Leu Asn Leu Gln 
             740                745                750
Asn Lys Gln Ser Leu Thr Met Asp Pro Val Val Lys Ser Lys Glu Ile 
         755                760                765
Glu Ala Lys Ile Lys Glu Leu Thr Ser Thr Cys Ser Pro Ile Ile Ser 
     770                775                780
Lys Pro Lys Pro Lys Val Glu Pro Pro Lys Glu Glu Gln Lys Asn Ala 
 785                790                795                800
Glu Gln Asn Gly Pro Val Asp Gly Gln Gly Asp Asn Pro Gly Pro Gln 
                 805                810                815
Ala Ala Glu Gln Gly Thr Asp Thr Ala Val Pro Ser Asp Ser Asp Lys 
             820                825                830
Lys Leu Pro Glu Met Asp Ile Asp 
         835                840



<210> 1098
<211> 6779
<212> DNA
<213> Rattus norvegicus
<308> AF078779
<400> 1098

cgggcgcgc  gcggttaca  actgtggtt  tgtacctgc  tcccacagc  aacttcacc  60
tgctcaaaa  aaagcagag  tccagggtg  aagcccagc  agtaactga  tttggtcct  120
acgaatctc  gtcagacaa  gctgacata  tctggatta  taagccatg  gtgcactct  180
tgctgcgca  ctgtgccat  atcagcgtc  tctcagtgt  catgaacac  cctatgacc  240
tcgagcact  tcctcccct  cagtatgtg  ccttcaccc  ggacacttt  ctgatgttt  300
tctacactg  agagatgat  gcaaagatg  acatacggg  aattgtcaa  ggcgatagc  360
cctatgtga  ggaccgctg  tgtgttttt  atggattca  ggtcttttg  ctttgggtt  420
ctctcgtgt  acaggtgtt  gaaatagct  acatagttg  tcagatgtc  ccttggggc  480
tgctgcgga  cccacggcc  ctcattatg  tccgggctt  caggattta  ttccgattc  540
aactgccaa  gacccgaat  acaaacatt  taaagcggt  aggagaaca  atatggagt  600
tctcaatct  cctcctctt  ttccttctt  tgtatggga  tttaggagt  cagatgttt  660
gaacattta  ctaccactg  gtagtcaat  acacaaagc  agggaatgt  acctggaat  720
gcttagcta  cccagatac  cactgctcg  cagagctag  agaaggcta  cagtgcccc  780
caggattta  atgcatgga  ctggaagac  tgggactta  caggcaaga  ctgggctac  840
gtggcttta  tgagatagg  acgagtata  tcacagtct  tgaggcttc  tctcaggaa  900
gctgggtat  cctcatgta  agagcaatc  acagtttcc  ccgttggcg  tcctacttc  960
acttcatca  gctgatttt  ttccttgcc  ggcttgtca  gaatgtgtt  attgctgtc  1020
tcattgaga  atttgcaga  atcagagta  aatttcaac  aatgtgggg  actcggagc  1080
gcacaactt  cactgccac  acgcagatg  tccatgaag  tgctgccgg  ggctggcag  1140
tggtagctg  ggatgtcaa  aagccccag  gacgtgccc  agcctgcct  cagaaaatg  1200
tgcggtcat  agttttcca  atgtttatc  tgagcatgg  gactgtgga  gtaatagtt  1260
ctgccagca  ctactacaa  ggagagaac  tcagaaggc  gtatgacga  ttctacctt  1320
cagaggtgg  ttttacagt  ctttttgat  tggaagcac  tctgaagat  tggtgtttg  1380
ggtttactg  ctacatcag  tcatctctc  acaagtttg  actacttct  gttattggg  1440
caactctcc  tgtataccc  gatctttat  attctcaat  tacctactt  caggttctt  1500
gggtagtcc  gcttattaa  atttcccca  cattggaag  ttttgtgta  aagatattt  1560
gtcccggga  aaaacttgg  agcttggtg  tgttcactg  cagtctcct  atagttatg  1620
ccgccatca  tttgcagat  ttctgcttc  tcgaagaac  ggacagatt  accacattt  1680
caagggcat  tatgtccat  ttccagatc  tcacccagg  aggatgggt  gatgtgatg  1740
atcagactc  gaatgctgt  gggcatatg  gggctccac  ggttgccat  tatttcatc  1800
tctaccatc  ctttgcaac  ctgatcctc  tgagtttgt  tgttgctgt  attttggac  1860
acttagaac  tgatgaaga  ctaaagaag  tcaaacaat  aaaacaaag  gaagcgaac  1920
cagatacca  agaaaaact  cctttgcgc  tgagaatct  cgaaaaatt  ccaaacaga  1980
cgcaaatgg  gaaaatctc  aaacttcct  cagatttta  agttcctaa  atcagggaa  2040
gcttcatga  gcagttcat  gaccgccag  aacaggaca  ctgctgtct  ttcagaatt  2100
tcccctcta  ctcttcctc  tcctgtgac  accccaagc  gcccacagt  gaagacaac  2160
aatacattg  tcaaaaact  cgcaagtct  ttttcagca  aagggcaag  aaccttctg  2220
aaaaggaga  cgcagtcac  aaaatctta  gagcttgca  tcgacagcg  atgctgagc  2280
gatcattcg  ggggcagcc  gcaaaggag  ggtcgatcc  cagcgtgca  catcacatc  2340
gccaggagc  caggtcact  agacatgga  ccaacagcc  gaggatcag  aggggcaaa  2400
ctcttgaaa  gttaactca  gatcattcc  atacggtgc  ctacagaaa  gcacaaaga  2460
aagacagtg  aataaagat  atccaggag  agaaggagc  agcagagat  aaaaggaag  2520
tgcaagaag  ggagctgcg  gagaaccac  catactttg  caagcctct  ttcatcgtg  2580
gtcgagaac  caggttcag  aacttctgc  gcgtggtgg  tcgagcacg  ttcaatgca  2640
ccaaaacag  ccctgtcac  ggagctgtg  aaaatacaa  gtaccacca  ctttatgat  2700
tgctgggac  tgtcaccta  ctggactgg  tcatgatca  tgtaaccat  tgctcttgc  2760
tttctatga  gttcgaatc  cccttccgg  gagtcatgc  tgcacccac  ttacagatc  2820
ctgaatatg  gtttgtgat  ttcatgagc  ttgagctta  tctgaagat  atggcagat  2880
gcttgtttt  cactccaac  gctgtcatc  gggactttg  tggcgtcat  gacatattt  2940
tctatcttg  gagcttgat  tttctttgt  ggatgcctc  aaatgtgcc  gctgagtca  3000
gagcccagc  cctgatggt  cttcggtgc  taagacctc  tcggatatt  aaactggtg  3060
cacaaatga  gaaagttgt  cgagaactt  tcagtggtt  caaggaaat  tttttggtc  3120
ccattctgt  gctgacact  atgcttgtt  ttgcaagct  tggtgttca  ctctttgcc  3180
gaaagctag  caagtgcaa  gaccccaac  ttatcagaa  ggaagactg  aacggcatc  3240
tcagaatta  tgtaagtgt  tccaagaac  taaatttaa  actaagacc  ggagagaaa  3300
aacctggat  ttgggtgcc  cgtgtttgg  caaatcctc  taactttaa  tttgacaat  3360
tgggaaatg  tatgctggc  ttgtttgaa  ttctgtcct  gaaaggctg  gtagaagtg  3420
gagatgtca  tattcatcg  gtggggccg  tccatggaa  ctatattca  gttttcgta  3480
tcctgggtt  catgattgg  ctgactctt  ttgtcggtg  agttattgc  aacttcaat  3540
aaaacaagg  gacagccct  ctgacggta  atcagagaa  atgggaaga  ctcaagagc  3600
gattgaaga  cgcacagcc  cttcatctc  cacctcggc  ggataatga  ggatttaga  3660
ctaaaatgt  tgacataac  cagcatccg  tttttaaaa  gacaattgc  ttgctggtt  3720
tggcccagt  tgtgttgct  tctgtcaag  gggatgttg  ggatcctgt  acagttcct  3780
tggcaacca  gtcggtcgt  ttcaccttc  tctttgtct  agaggttac  atgaagatc  3840
tagcaatgt  accagctgg  ttctggcaa  gcagaagaa  ccgatatga  ctcttggtg  3900
cgtctcttg  tgttgtgtg  gtggtgctc  attttgctc  gctgaatgc  tacacctac  3960
tgatgggag  ctgtgtgat  gtctttaga  ttttctcca  ctgtggaaa  catgtgaca  4020
taaagatgc  ccttttgac  gtggttgtc  gcatgtaca  gagcttctt  atcatcgta  4080
gaatgtttc  cttgctgct  tgctatgcc  ttgctgggg  ggttctgtt  ggcactgta  4140
agtatggag  gaacattaa  aggcatgcc  atttttctt  agctggcaa  gccattact  4200
tattgttcc  aattgtcac  ggggaagac  ggaataaga  tatgcatga  tgtatggtt  4260
agcctccat  ttgtactcc  gatgaattt  catattggg  aacagactg  ggcaattat  4320
caggggcac  tatgtactt  tgctcattc  atgtcatca  cgcctacat  atgctgaat  4380
tacttgtag  cataattgt  gagaatttc  ctttgtttt  ttccactga  gaggaccag  4440
ttttgagtt  caatgatct  cgccatttt  aaatcatat  gaatatggt  gatgataac  4500
agaggtgtg  tcccacctt  cgagtgaag  tcctgctac  gctactgcg  gggaggcta  4560
aagtggacc  tgataaaga  aagctcctg  ttaagcaca  gtgctatga  atggagagg  4620
tgcacaatg  tggtgatgt  accttccat  atgtcttga  catgctgtc  taccgctct  4680
tagacatca  gaagagcct  cagctagag  aactgctgg  aagggagca  ctggagtac  4740
ccatagagg  ggaggtggc  aagcagact  ttcgcatgt  gctgaagaa  tgcttaaaa  4800
gcatccggg  taaacagca  cagtcatgc  gcatcatcc  cagcctgag  gagagccag  4860
agcaagagt  gagccgatt  ctgaatcct  ccagcattg  gaccaccca  ccaagcgaa  4920
ataccaacg  caacagcca  gaccacaat  cgcaacctg  gtcaagcag  cagcagcag  4980
tcttgagcc  tactctgtc  gacagagga  gaagtcgac  ggatgcagc  gatactggg  5040
aaccccaaa  aaagattgg  caatggcgt  tgccctcag  tcccaaacc  ataagccat  5100
ctgtgtctt  ggttaacct  cggtttgga  gaaggacaa  aatgaagtc  gtggtgtgc  5160
agatgaacc  catgccaga  acagcttcc  gtggctccg  agttaaaaa  tggtggacc  5220
gacagctga  tgtggagag  gacgagagt  gagatgacc  cctagatat  tagagggga  5280
gcaaagcat  gggatttat  gggtgaaaa  cactgccta  tctcttgtt  tatctctga  5340
agagcaaac  gtagttgcc  aaccctaaa  ttcacccga  catggcatt  tcagaatta  5400
cttttgttc  tttattgga  tggtccctc  aagagtatg  agtttcaga  tactctcat  5460
tattaaaga  aatctgggg  ttgggatgt  agtcagtga  agaccactt  tccaaccta  5520
gaaaacccg  gtgtttaaa  cccagaaat  caagaaaag  aggaaaata  gtataatgc  5580
gtattgata  tattagaag  tgcatcaat  gtagatgtg  attaaatat  catgtattc  5640
gtctgtgta  gataagctg  actcacctg  actcctgta  tttgttact  ctcctctca  5700
agagtgcta  gcccatact  gcccatatt  atagtacag  agttgtagc  ctagttcac  5760
tttttttcc  atttccaat  gaaatactt  ccttgggag  aattattta  gattgatct  5820
aaaaggtca  tcatgctaa  atgacagca  cttcaaaac  acagattct  gatttttaa  5880
aacattcct  ttctcatat  atttaaaaa  tatgcctga  gttaaaaaa  ttagacaat  5940
tgatttttt  tttcaagta  tctaattga  ctgtggcct  cttccaaga  agttatata  6000
gtaggtccc  tgtaaagga  ctggctata  atataattg  tatataaca  acctgtagg  6060
atattattc  tggacttga  gagacaaaa  tattttgaa  tctttaaaa  ccctttaaa  6120
aactgagtt  ataaaaaaa  aataaaagt  ttggagtca  catagctaa  agtttacac  6180
tgagactta  tgtggactt  atggcttat  cttgctgta  ccattttgc  atgaatcag  6240
aggaacatt  tgggttggc  ttaatacac  attactatg  agattgaaa  taatttccc  6300
gcttccaga  ttatctatt  aaataataa  agaagggtg  caaaacttc  ctctaaacc  6360
cattgggaa  accacaaca  aattatatt  tcccacaca  caatgctcc  ggttctctg  6420
gaaaagtgg  aatataaaa  tattggaaa  tattgatgg  ccctggctg  gcagagtct  6480
ccctgagtt  tcattatca  ttgcatatt  gatgatcag  ttattttaa  agattgagt  6540
tgtaaaaat  ccctgatgc  taggttgct  tatgatatc  ttttgtcta  ttaaccttc  6600
tcaaatagc  aaacattgt  tccttccta  acagaagat  tgatataat  tgcccatct  6660
ctgctttta  gattacttg  gactattag  taataggca  ttcaagttc  tgccgccaa  6720
gggcctttt  attgggttt  atgtttggt  agaatttga  ttttggata  aaaagccgg  6779



<210> 1099
<211> 1737
<212> PRT
<213> Rattus norvegicus
<308> AAC68885
<400> 1099

Met Leu Lys Arg Lys Gln Ser Ser Arg Val Glu Ala Gln Pro Val Thr 
  1               5                  10                  15
Asp Phe Gly Pro Asp Glu Ser Leu Ser Asp Asn Ala Asp Ile Leu Trp 
             20                  25                  30
Ile Asn Lys Pro Trp Val His Ser Leu Leu Arg Ile Cys Ala Ile Ile 
         35                  40                  45
Ser Val Ile Ser Val Cys Met Asn Thr Pro Met Thr Phe Glu His Tyr 
     50                  55                  60
Pro Pro Leu Gln Tyr Val Thr Phe Thr Leu Asp Thr Leu Leu Met Phe 
 65                  70                  75                  80
Leu Tyr Thr Ala Glu Met Ile Ala Lys Met His Ile Arg Gly Ile Val 
                 85                  90                  95
Lys Gly Asp Ser Ser Tyr Val Lys Asp Arg Trp Cys Val Phe Asp Gly 
             100                105                110
Phe Met Val Phe Cys Leu Trp Val Ser Leu Val Leu Gln Val Phe Glu 
         115                120                125
Ile Ala Asp Ile Val Asp Gln Met Ser Pro Trp Gly Met Leu Arg Ile 
     130                135                140
Pro Arg Pro Leu Ile Met Ile Arg Ala Phe Arg Ile Tyr Phe Arg Phe 
 145                150                155                160
Glu Leu Pro Arg Thr Arg Ile Thr Asn Ile Leu Lys Arg Ser Gly Glu 
                 165                170                175
Gln Ile Trp Ser Val Ser Ile Phe Leu Leu Phe Phe Leu Leu Leu Tyr 
             180                185                190
Gly Ile Leu Gly Val Gln Met Phe Gly Thr Phe Thr Tyr His Cys Val 
         195                200                205
Val Asn Asp Thr Lys Pro Gly Asn Val Thr Trp Asn Ser Leu Ala Ile 
     210                215                220
Pro Asp Thr His Cys Ser Pro Glu Leu Glu Glu Gly Tyr Gln Cys Pro 
 225                230                235                240
Pro Gly Phe Lys Cys Met Asp Leu Glu Asp Leu Gly Leu Ser Arg Gln 
                 245                250                255
Glu Leu Gly Tyr Ser Gly Phe Asn Glu Ile Gly Thr Ser Ile Phe Thr 
             260                265                270
Val Tyr Glu Ala Ser Ser Gln Glu Gly Trp Val Phe Leu Met Tyr Arg 
         275                280                285
Ala Ile Asp Ser Phe Pro Arg Trp Arg Ser Tyr Phe Tyr Phe Ile Thr 
     290                295                300
Leu Ile Phe Phe Leu Ala Trp Leu Val Lys Asn Val Phe Ile Ala Val 
 305                310                315                320
Ile Ile Glu Thr Phe Ala Glu Ile Arg Val Gln Phe Gln Gln Met Trp 
                 325                330                335
Gly Thr Arg Ser Ser Thr Thr Ser Thr Ala Thr Thr Gln Met Phe His 
             340                345                350
Glu Asp Ala Ala Gly Gly Trp Gln Leu Val Ala Val Asp Val Asn Lys 
         355                360                365
Pro Gln Gly Arg Ala Pro Ala Cys Leu Gln Lys Met Met Arg Ser Ser 
     370                375                380
Val Phe His Met Phe Ile Leu Ser Met Val Thr Val Asp Val Ile Val 
 385                390                395                400
Ala Ala Ser Asn Tyr Tyr Lys Gly Glu Asn Phe Arg Arg Gln Tyr Asp 
                 405                410                415
Glu Phe Tyr Leu Ala Glu Val Ala Phe Thr Val Leu Phe Asp Leu Glu 
             420                425                430
Ala Leu Leu Lys Ile Trp Cys Leu Gly Phe Thr Gly Tyr Ile Ser Ser 
         435                440                445
Ser Leu His Lys Phe Glu Leu Leu Leu Val Ile Gly Thr Thr Leu His 
     450                455                460
Val Tyr Pro Asp Leu Tyr His Ser Gln Phe Thr Tyr Phe Gln Val Leu 
 465                470                475                480
Arg Val Val Arg Leu Ile Lys Ile Ser Pro Ala Leu Glu Asp Phe Val 
                 485                490                495
Tyr Lys Ile Phe Gly Pro Gly Lys Lys Leu Gly Ser Leu Val Val Phe 
             500                505                510
Thr Ala Ser Leu Leu Ile Val Met Ser Ala Ile Ser Leu Gln Met Phe 
         515                520                525
Cys Phe Val Glu Glu Leu Asp Arg Phe Thr Thr Phe Pro Arg Ala Phe 
     530                535                540
Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val Met 
 545                550                555                560
Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Leu Val Ala 
                 565                570                575
Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu Ser 
             580                585                590
Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp Leu 
         595                600                605
Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr Lys 
     610                615                620
Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn Arg 
 625                630                635                640
Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val Pro 
                 645                650                655
Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln Gln 
             660                665                670
Asp Thr Cys Cys Leu Phe Arg Ile Leu Pro Ser Thr Ser Ser Ser Ser 
         675                680                685
Cys Asp Asn Pro Lys Arg Pro Thr Val Glu Asp Asn Lys Tyr Ile Asp 
     690                695                700
Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu Leu 
 705                710                715                720
Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg Gln 
                 725                730                735
Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg Ser 
             740                745                750
Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu Arg 
         755                760                765
His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu Thr 
     770                775                780
Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln Arg 
 785                790                795                800
Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala Glu 
                 805                810                815
Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro Tyr 
             820                825                830
Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg Asn 
         835                840                845
Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr Asp 
     850                855                860
Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr Asp 
 865                870                875                880
Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Thr Val Thr 
                 885                890                895
Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg Val 
             900                905                910
Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile Phe 
         915                920                925
Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe Phe 
     930                935                940
Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile Phe 
 945                950                955                960
Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn Val 
                 965                970                975
Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu Arg 
             980                985                990
Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val Arg 
         995                1000                1005
Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu Leu 
     1010                1015                1020
Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe Ala 
 1025                1030                1035                1040
Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu Asp 
                 1045                1050                1055
Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu Asn 
             1060                1065                1070
Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro Arg 
         1075                1080                1085
Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn Ala 
     1090                1095                1100
Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu Val 
 1105                1110                1115                1120
Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr Ile 
                 1125                1130                1135
His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe Val 
             1140                1145                1150
Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu Leu 
         1155                1160                1165
Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys Ile 
     1170                1175                1180
Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe Arg 
 1185                1190                1195                1200
Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr Ile 
                 1205                1210                1215
Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp Asp 
             1220                1225                1230
Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val Phe 
         1235                1240                1245
Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met Ser 
     1250                1255                1260
Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu Val 
 1265                1270                1275                1280
Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu Asn 
                 1285                1290                1295
Ala Tyr Thr Tyr Met Met Gly Ala Cys Val Ile Val Phe Arg Phe Phe 
             1300                1305                1310
Ser Ile Cys Gly Lys His Val Thr Leu Lys Met Leu Leu Leu Thr Val 
         1315                1320                1325
Val Val Ser Met Tyr Lys Ser Phe Phe Ile Ile Val Gly Met Phe Leu 
     1330                1335                1340
Leu Leu Leu Cys Tyr Ala Phe Ala Gly Val Val Leu Phe Gly Thr Val 
 1345                1350                1355                1360
Lys Tyr Gly Glu Asn Ile Asn Arg His Ala Asn Phe Ser Ser Ala Gly 
                 1365                1370                1375
Lys Ala Ile Thr Val Leu Phe Arg Ile Val Thr Gly Glu Asp Trp Asn 
             1380                1385                1390
Lys Ile Met His Asp Cys Met Val Gln Pro Pro Phe Cys Thr Pro Asp 
         1395                1400                1405
Glu Phe Thr Tyr Trp Ala Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu 
     1410                1415                1420
Met Tyr Phe Cys Ser Phe Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn 
 1425                1430                1435                1440
Leu Leu Val Ala Ile Ile Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr 
                 1445                1450                1455
Glu Glu Asp Gln Leu Leu Ser Tyr Asn Asp Leu Arg His Phe Gln Ile 
             1460                1465                1470
Ile Trp Asn Met Val Asp Asp Asn Glu Arg Cys Asp Pro Thr Phe Arg 
         1475                1480                1485
Val Lys Phe Leu Leu Arg Leu Leu Arg Gly Arg Leu Glu Val Asp Leu 
     1490                1495                1500
Asp Lys Asp Lys Leu Leu Phe Lys His Met Cys Tyr Glu Met Glu Arg 
 1505                1510                1515                1520
Leu His Asn Gly Gly Asp Val Thr Phe His Asp Val Leu Ser Met Leu 
                 1525                1530                1535
Ser Tyr Arg Ser Val Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu Leu 
             1540                1545                1550
Leu Ala Arg Glu Gln Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala Lys 
         1555                1560                1565
Gln Thr Ile Arg Met Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg Ala 
     1570                1575                1580
Lys Gln Gln Gln Ser Cys Ser Ile Ile His Ser Leu Arg Glu Ser Gln 
 1585                1590                1595                1600
Gln Gln Glu Leu Ser Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr Thr 
                 1605                1610                1615
Gln Pro Ser Glu Asp Thr Asn Ala Asn Ser Gln Asp His Asn Thr Gln 
             1620                1625                1630
Pro Glu Ser Ser Ser Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser Asp 
         1635                1640                1645
Arg Gly Gly Ser Arg Gln Asp Ala Ala Asp Thr Gly Lys Pro Gln Arg 
     1650                1655                1660
Lys Ile Gly Gln Trp Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser His 
 1665                1670                1675                1680
Ser Val Ser Ser Val Asn Leu Arg Phe Gly Gly Arg Thr Thr Met Lys 
                 1685                1690                1695
Ser Val Val Cys Lys Met Asn Pro Met Pro Asp Thr Ala Ser Cys Gly 
             1700                1705                1710
Ser Glu Val Lys Lys Trp Trp Thr Arg Gln Leu Thr Val Glu Ser Asp 
         1715                1720                1725
Glu Ser Gly Asp Asp Leu Leu Asp Ile 
     1730                1735



<210> 1100
<211> 380
<212> DNA
<213> Homo sapiens
<308> AW295007
<400> 1100

ttttttttt  tttttatca  agagatcat  gaagcttta  tagccttta  acaccagca  60
gttgattag  gacacagta  cagggggtc  ccggttctt  tcttctttg  ctccatgtc  120
tctttctta  tgtcccaga  caaggctgt  gaaaattcc  atacattct  actccacta  180
agtgacaat  tgatcttcc  aagtagaga  aacagcgga  gctaatggg  gagctcgtc  240
gtaatggac  cttgcttaa  attttagtg  ctgcggtct  cttttccag  aggttcctt  300
ccctgatgc  gaaaacaga  ttgcgaagt  tttggtcga  gtatttgtt  tcctcaatt  360
ctgaacgtt  ggagtggtcg  380



<210> 1101
<211> 1172
<212> PRT
<213> Homo sapiens
<308> CAC40696
<400> 1101

Phe Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val 
  1               5                  10                  15
Met Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Val Val 
             20                  25                  30
Ala Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu 
         35                  40                  45
Ser Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp 
     50                  55                  60
Leu Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr 
 65                  70                  75                  80
Lys Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn 
                 85                  90                  95
Arg Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val 
             100                105                110
Pro Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln 
         115                120                125
Gln Asp Thr Cys Cys Leu Leu Arg Ser Leu Pro Thr Thr Ser Ser Ser 
     130                135                140
Ser Cys Asp His Ser Lys Arg Ser Ala Ile Glu Asp Asn Lys Tyr Ile 
 145                150                155                160
Asp Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu 
                 165                170                175
Leu Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg 
             180                185                190
Gln Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg 
         195                200                205
Ser Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu 
     210                215                220
Arg His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu 
 225                230                235                240
Thr Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln 
                 245                250                255
Arg Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala 
             260                265                270
Glu Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro 
         275                280                285
Tyr Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg 
     290                295                300
Asn Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr 
 305                310                315                320
Asp Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr 
                 325                330                335
Asp Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Ile Val 
             340                345                350
Thr Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg 
         355                360                365
Val Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile 
     370                375                380
Phe Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe 
 385                390                395                400
Phe Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile 
                 405                410                415
Phe Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn 
             420                425                430
Val Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu 
         435                440                445
Arg Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val 
     450                455                460
Arg Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu 
 465                470                475                480
Leu Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe 
                 485                490                495
Ala Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu 
             500                505                510
Asp Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu 
         515                520                525
Asn Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro 
     530                535                540
Arg Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn 
 545                550                555                560
Ala Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu 
                 565                570                575
Val Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr 
             580                585                590
Ile His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe 
         595                600                605
Val Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu 
     610                615                620
Leu Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys 
 625                630                635                640
Ile Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe 
                 645                650                655
Arg Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr 
             660                665                670
Ile Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp 
         675                680                685
Asp Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val 
     690                695                700
Phe Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met 
 705                710                715                720
Ser Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu 
                 725                730                735
Val Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu 
             740                745                750
Val Thr Leu Lys Met Leu Leu Leu Thr Val Val Val Ser Met Tyr Lys 
         755                760                765
Ser Phe Phe Ile Ile Val Gly Met Phe Leu Leu Leu Leu Cys Tyr Ala 
     770                775                780
Phe Ala Gly Val Val Leu Phe Gly Thr Val Lys Tyr Gly Glu Asn Ile 
 785                790                795                800
Asn Arg His Ala Asn Phe Ser Ser Ala Gly Lys Ala Ile Thr Val Leu 
                 805                810                815
Phe Arg Ile Val Thr Gly Glu Asp Trp Asn Lys Ile Met His Asp Cys 
             820                825                830
Met Val Gln Pro Pro Phe Cys Thr Pro Asp Glu Phe Thr Tyr Trp Ala 
         835                840                845
Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu Met Tyr Phe Cys Ser Phe 
     850                855                860
Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn Leu Leu Val Ala Ile Ile 
 865                870                875                880
Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr Glu Glu Asp Gln Leu Leu 
                 885                890                895
Ser Tyr Asn Asp Leu Arg His Phe Gln Ile Ile Trp Asn Met Val Asp 
             900                905                910
Asp Lys Arg Glu Gly Val Ile Pro Thr Phe Arg Val Lys Phe Leu Leu 
         915                920                925
Arg Leu Leu Arg Gly Arg Leu Glu Val Asp Leu Asp Lys Asp Lys Leu 
     930                935                940
Leu Phe Lys His Met Cys Tyr Glu Met Glu Arg Leu His Asn Gly Gly 
 945                950                955                960
Asp Val Thr Phe His Asp Val Leu Ser Met Leu Ser Tyr Arg Ser Val 
                 965                970                975
Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu Leu Leu Ala Arg Glu Gln 
             980                985                990
Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala Lys Gln Thr Ile Arg Met 
         995                1000                1005
Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg Ala Lys Gln Gln Gln Ser 
     1010                1015                1020
Cys Ser Ile Ile His Ser Leu Arg Glu Ser Gln Gln Gln Glu Leu Ser 
 1025                1030                1035                1040
Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr Thr Gln Pro Ser Glu Asp 
                 1045                1050                1055
Thr Asn Ala Asn Ser Gln Asp Asn Ser Met Gln Pro Glu Thr Ser Ser 
             1060                1065                1070
Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser Asp Arg Gly Gly Ser Arg 
         1075                1080                1085
Gln Asp Ala Ala Asp Ala Gly Lys Pro Gln Arg Lys Phe Gly Gln Trp 
     1090                1095                1100
Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser His Ser Val Ser Ser Val 
 1105                1110                1115                1120
Asn Leu Arg Phe Gly Gly Arg Thr Thr Met Lys Ser Val Val Cys Lys 
                 1125                1130                1135
Met Asn Pro Met Thr Asp Ala Ala Ser Cys Gly Ser Glu Val Lys Lys 
             1140                1145                1150
Trp Trp Thr Arg Gln Leu Thr Val Glu Ser Asp Glu Ser Gly Asp Asp 
         1155                1160                1165
Leu Leu Asp Ile 
     1170



<210> 1102
<211> 6779
<212> DNA
<213> Rattus norvegicus
<308> AF078779
<400> 1102

cgggcgcgc  gcggttaca  actgtggtt  tgtacctgc  tcccacagc  aacttcacc  60
tgctcaaaa  aaagcagag  tccagggtg  aagcccagc  agtaactga  tttggtcct  120
acgaatctc  gtcagacaa  gctgacata  tctggatta  taagccatg  gtgcactct  180
tgctgcgca  ctgtgccat  atcagcgtc  tctcagtgt  catgaacac  cctatgacc  240
tcgagcact  tcctcccct  cagtatgtg  ccttcaccc  ggacacttt  ctgatgttt  300
tctacactg  agagatgat  gcaaagatg  acatacggg  aattgtcaa  ggcgatagc  360
cctatgtga  ggaccgctg  tgtgttttt  atggattca  ggtcttttg  ctttgggtt  420
ctctcgtgt  acaggtgtt  gaaatagct  acatagttg  tcagatgtc  ccttggggc  480
tgctgcgga  cccacggcc  ctcattatg  tccgggctt  caggattta  ttccgattc  540
aactgccaa  gacccgaat  acaaacatt  taaagcggt  aggagaaca  atatggagt  600
tctcaatct  cctcctctt  ttccttctt  tgtatggga  tttaggagt  cagatgttt  660
gaacattta  ctaccactg  gtagtcaat  acacaaagc  agggaatgt  acctggaat  720
gcttagcta  cccagatac  cactgctcg  cagagctag  agaaggcta  cagtgcccc  780
caggattta  atgcatgga  ctggaagac  tgggactta  caggcaaga  ctgggctac  840
gtggcttta  tgagatagg  acgagtata  tcacagtct  tgaggcttc  tctcaggaa  900
gctgggtat  cctcatgta  agagcaatc  acagtttcc  ccgttggcg  tcctacttc  960
acttcatca  gctgatttt  ttccttgcc  ggcttgtca  gaatgtgtt  attgctgtc  1020
tcattgaga  atttgcaga  atcagagta  aatttcaac  aatgtgggg  actcggagc  1080
gcacaactt  cactgccac  acgcagatg  tccatgaag  tgctgccgg  ggctggcag  1140
tggtagctg  ggatgtcaa  aagccccag  gacgtgccc  agcctgcct  cagaaaatg  1200
tgcggtcat  agttttcca  atgtttatc  tgagcatgg  gactgtgga  gtaatagtt  1260
ctgccagca  ctactacaa  ggagagaac  tcagaaggc  gtatgacga  ttctacctt  1320
cagaggtgg  ttttacagt  ctttttgat  tggaagcac  tctgaagat  tggtgtttg  1380
ggtttactg  ctacatcag  tcatctctc  acaagtttg  actacttct  gttattggg  1440
caactctcc  tgtataccc  gatctttat  attctcaat  tacctactt  caggttctt  1500
gggtagtcc  gcttattaa  atttcccca  cattggaag  ttttgtgta  aagatattt  1560
gtcccggga  aaaacttgg  agcttggtg  tgttcactg  cagtctcct  atagttatg  1620
ccgccatca  tttgcagat  ttctgcttc  tcgaagaac  ggacagatt  accacattt  1680
caagggcat  tatgtccat  ttccagatc  tcacccagg  aggatgggt  gatgtgatg  1740
atcagactc  gaatgctgt  gggcatatg  gggctccac  ggttgccat  tatttcatc  1800
tctaccatc  ctttgcaac  ctgatcctc  tgagtttgt  tgttgctgt  attttggac  1860
acttagaac  tgatgaaga  ctaaagaag  tcaaacaat  aaaacaaag  gaagcgaac  1920
cagatacca  agaaaaact  cctttgcgc  tgagaatct  cgaaaaatt  ccaaacaga  1980
cgcaaatgg  gaaaatctc  aaacttcct  cagatttta  agttcctaa  atcagggaa  2040
gcttcatga  gcagttcat  gaccgccag  aacaggaca  ctgctgtct  ttcagaatt  2100
tcccctcta  ctcttcctc  tcctgtgac  accccaagc  gcccacagt  gaagacaac  2160
aatacattg  tcaaaaact  cgcaagtct  ttttcagca  aagggcaag  aaccttctg  2220
aaaaggaga  cgcagtcac  aaaatctta  gagcttgca  tcgacagcg  atgctgagc  2280
gatcattcg  ggggcagcc  gcaaaggag  ggtcgatcc  cagcgtgca  catcacatc  2340
gccaggagc  caggtcact  agacatgga  ccaacagcc  gaggatcag  aggggcaaa  2400
ctcttgaaa  gttaactca  gatcattcc  atacggtgc  ctacagaaa  gcacaaaga  2460
aagacagtg  aataaagat  atccaggag  agaaggagc  agcagagat  aaaaggaag  2520
tgcaagaag  ggagctgcg  gagaaccac  catactttg  caagcctct  ttcatcgtg  2580
gtcgagaac  caggttcag  aacttctgc  gcgtggtgg  tcgagcacg  ttcaatgca  2640
ccaaaacag  ccctgtcac  ggagctgtg  aaaatacaa  gtaccacca  ctttatgat  2700
tgctgggac  tgtcaccta  ctggactgg  tcatgatca  tgtaaccat  tgctcttgc  2760
tttctatga  gttcgaatc  cccttccgg  gagtcatgc  tgcacccac  ttacagatc  2820
ctgaatatg  gtttgtgat  ttcatgagc  ttgagctta  tctgaagat  atggcagat  2880
gcttgtttt  cactccaac  gctgtcatc  gggactttg  tggcgtcat  gacatattt  2940
tctatcttg  gagcttgat  tttctttgt  ggatgcctc  aaatgtgcc  gctgagtca  3000
gagcccagc  cctgatggt  cttcggtgc  taagacctc  tcggatatt  aaactggtg  3060
cacaaatga  gaaagttgt  cgagaactt  tcagtggtt  caaggaaat  tttttggtc  3120
ccattctgt  gctgacact  atgcttgtt  ttgcaagct  tggtgttca  ctctttgcc  3180
gaaagctag  caagtgcaa  gaccccaac  ttatcagaa  ggaagactg  aacggcatc  3240
tcagaatta  tgtaagtgt  tccaagaac  taaatttaa  actaagacc  ggagagaaa  3300
aacctggat  ttgggtgcc  cgtgtttgg  caaatcctc  taactttaa  tttgacaat  3360
tgggaaatg  tatgctggc  ttgtttgaa  ttctgtcct  gaaaggctg  gtagaagtg  3420
gagatgtca  tattcatcg  gtggggccg  tccatggaa  ctatattca  gttttcgta  3480
tcctgggtt  catgattgg  ctgactctt  ttgtcggtg  agttattgc  aacttcaat  3540
aaaacaagg  gacagccct  ctgacggta  atcagagaa  atgggaaga  ctcaagagc  3600
gattgaaga  cgcacagcc  cttcatctc  cacctcggc  ggataatga  ggatttaga  3660
ctaaaatgt  tgacataac  cagcatccg  tttttaaaa  gacaattgc  ttgctggtt  3720
tggcccagt  tgtgttgct  tctgtcaag  gggatgttg  ggatcctgt  acagttcct  3780
tggcaacca  gtcggtcgt  ttcaccttc  tctttgtct  agaggttac  atgaagatc  3840
tagcaatgt  accagctgg  ttctggcaa  gcagaagaa  ccgatatga  ctcttggtg  3900
cgtctcttg  tgttgtgtg  gtggtgctc  attttgctc  gctgaatgc  tacacctac  3960
tgatgggag  ctgtgtgat  gtctttaga  ttttctcca  ctgtggaaa  catgtgaca  4020
taaagatgc  ccttttgac  gtggttgtc  gcatgtaca  gagcttctt  atcatcgta  4080
gaatgtttc  cttgctgct  tgctatgcc  ttgctgggg  ggttctgtt  ggcactgta  4140
agtatggag  gaacattaa  aggcatgcc  atttttctt  agctggcaa  gccattact  4200
tattgttcc  aattgtcac  ggggaagac  ggaataaga  tatgcatga  tgtatggtt  4260
agcctccat  ttgtactcc  gatgaattt  catattggg  aacagactg  ggcaattat  4320
caggggcac  tatgtactt  tgctcattc  atgtcatca  cgcctacat  atgctgaat  4380
tacttgtag  cataattgt  gagaatttc  ctttgtttt  ttccactga  gaggaccag  4440
ttttgagtt  caatgatct  cgccatttt  aaatcatat  gaatatggt  gatgataac  4500
agaggtgtg  tcccacctt  cgagtgaag  tcctgctac  gctactgcg  gggaggcta  4560
aagtggacc  tgataaaga  aagctcctg  ttaagcaca  gtgctatga  atggagagg  4620
tgcacaatg  tggtgatgt  accttccat  atgtcttga  catgctgtc  taccgctct  4680
tagacatca  gaagagcct  cagctagag  aactgctgg  aagggagca  ctggagtac  4740
ccatagagg  ggaggtggc  aagcagact  ttcgcatgt  gctgaagaa  tgcttaaaa  4800
gcatccggg  taaacagca  cagtcatgc  gcatcatcc  cagcctgag  gagagccag  4860
agcaagagt  gagccgatt  ctgaatcct  ccagcattg  gaccaccca  ccaagcgaa  4920
ataccaacg  caacagcca  gaccacaat  cgcaacctg  gtcaagcag  cagcagcag  4980
tcttgagcc  tactctgtc  gacagagga  gaagtcgac  ggatgcagc  gatactggg  5040
aaccccaaa  aaagattgg  caatggcgt  tgccctcag  tcccaaacc  ataagccat  5100
ctgtgtctt  ggttaacct  cggtttgga  gaaggacaa  aatgaagtc  gtggtgtgc  5160
agatgaacc  catgccaga  acagcttcc  gtggctccg  agttaaaaa  tggtggacc  5220
gacagctga  tgtggagag  gacgagagt  gagatgacc  cctagatat  tagagggga  5280
gcaaagcat  gggatttat  gggtgaaaa  cactgccta  tctcttgtt  tatctctga  5340
agagcaaac  gtagttgcc  aaccctaaa  ttcacccga  catggcatt  tcagaatta  5400
cttttgttc  tttattgga  tggtccctc  aagagtatg  agtttcaga  tactctcat  5460
tattaaaga  aatctgggg  ttgggatgt  agtcagtga  agaccactt  tccaaccta  5520
gaaaacccg  gtgtttaaa  cccagaaat  caagaaaag  aggaaaata  gtataatgc  5580
gtattgata  tattagaag  tgcatcaat  gtagatgtg  attaaatat  catgtattc  5640
gtctgtgta  gataagctg  actcacctg  actcctgta  tttgttact  ctcctctca  5700
agagtgcta  gcccatact  gcccatatt  atagtacag  agttgtagc  ctagttcac  5760
tttttttcc  atttccaat  gaaatactt  ccttgggag  aattattta  gattgatct  5820
aaaaggtca  tcatgctaa  atgacagca  cttcaaaac  acagattct  gatttttaa  5880
aacattcct  ttctcatat  atttaaaaa  tatgcctga  gttaaaaaa  ttagacaat  5940
tgatttttt  tttcaagta  tctaattga  ctgtggcct  cttccaaga  agttatata  6000
gtaggtccc  tgtaaagga  ctggctata  atataattg  tatataaca  acctgtagg  6060
atattattc  tggacttga  gagacaaaa  tattttgaa  tctttaaaa  ccctttaaa  6120
aactgagtt  ataaaaaaa  aataaaagt  ttggagtca  catagctaa  agtttacac  6180
tgagactta  tgtggactt  atggcttat  cttgctgta  ccattttgc  atgaatcag  6240
aggaacatt  tgggttggc  ttaatacac  attactatg  agattgaaa  taatttccc  6300
gcttccaga  ttatctatt  aaataataa  agaagggtg  caaaacttc  ctctaaacc  6360
cattgggaa  accacaaca  aattatatt  tcccacaca  caatgctcc  ggttctctg  6420
gaaaagtgg  aatataaaa  tattggaaa  tattgatgg  ccctggctg  gcagagtct  6480
ccctgagtt  tcattatca  ttgcatatt  gatgatcag  ttattttaa  agattgagt  6540
tgtaaaaat  ccctgatgc  taggttgct  tatgatatc  ttttgtcta  ttaaccttc  6600
tcaaatagc  aaacattgt  tccttccta  acagaagat  tgatataat  tgcccatct  6660
ctgctttta  gattacttg  gactattag  taataggca  ttcaagttc  tgccgccaa  6720
gggcctttt  attgggttt  atgtttggt  agaatttga  ttttggata  aaaagccgg  6779



<210> 1103
<211> 1737
<212> PRT
<213> Rattus norvegicus
<308> AAC68885
<400> 1103

Met Leu Lys Arg Lys Gln Ser Ser Arg Val Glu Ala Gln Pro Val Thr 
  1               5                  10                  15
Asp Phe Gly Pro Asp Glu Ser Leu Ser Asp Asn Ala Asp Ile Leu Trp 
             20                  25                  30
Ile Asn Lys Pro Trp Val His Ser Leu Leu Arg Ile Cys Ala Ile Ile 
         35                  40                  45
Ser Val Ile Ser Val Cys Met Asn Thr Pro Met Thr Phe Glu His Tyr 
     50                  55                  60
Pro Pro Leu Gln Tyr Val Thr Phe Thr Leu Asp Thr Leu Leu Met Phe 
 65                  70                  75                  80
Leu Tyr Thr Ala Glu Met Ile Ala Lys Met His Ile Arg Gly Ile Val 
                 85                  90                  95
Lys Gly Asp Ser Ser Tyr Val Lys Asp Arg Trp Cys Val Phe Asp Gly 
             100                105                110
Phe Met Val Phe Cys Leu Trp Val Ser Leu Val Leu Gln Val Phe Glu 
         115                120                125
Ile Ala Asp Ile Val Asp Gln Met Ser Pro Trp Gly Met Leu Arg Ile 
     130                135                140
Pro Arg Pro Leu Ile Met Ile Arg Ala Phe Arg Ile Tyr Phe Arg Phe 
 145                150                155                160
Glu Leu Pro Arg Thr Arg Ile Thr Asn Ile Leu Lys Arg Ser Gly Glu 
                 165                170                175
Gln Ile Trp Ser Val Ser Ile Phe Leu Leu Phe Phe Leu Leu Leu Tyr 
             180                185                190
Gly Ile Leu Gly Val Gln Met Phe Gly Thr Phe Thr Tyr His Cys Val 
         195                200                205
Val Asn Asp Thr Lys Pro Gly Asn Val Thr Trp Asn Ser Leu Ala Ile 
     210                215                220
Pro Asp Thr His Cys Ser Pro Glu Leu Glu Glu Gly Tyr Gln Cys Pro 
 225                230                235                240
Pro Gly Phe Lys Cys Met Asp Leu Glu Asp Leu Gly Leu Ser Arg Gln 
                 245                250                255
Glu Leu Gly Tyr Ser Gly Phe Asn Glu Ile Gly Thr Ser Ile Phe Thr 
             260                265                270
Val Tyr Glu Ala Ser Ser Gln Glu Gly Trp Val Phe Leu Met Tyr Arg 
         275                280                285
Ala Ile Asp Ser Phe Pro Arg Trp Arg Ser Tyr Phe Tyr Phe Ile Thr 
     290                295                300
Leu Ile Phe Phe Leu Ala Trp Leu Val Lys Asn Val Phe Ile Ala Val 
 305                310                315                320
Ile Ile Glu Thr Phe Ala Glu Ile Arg Val Gln Phe Gln Gln Met Trp 
                 325                330                335
Gly Thr Arg Ser Ser Thr Thr Ser Thr Ala Thr Thr Gln Met Phe His 
             340                345                350
Glu Asp Ala Ala Gly Gly Trp Gln Leu Val Ala Val Asp Val Asn Lys 
         355                360                365
Pro Gln Gly Arg Ala Pro Ala Cys Leu Gln Lys Met Met Arg Ser Ser 
     370                375                380
Val Phe His Met Phe Ile Leu Ser Met Val Thr Val Asp Val Ile Val 
 385                390                395                400
Ala Ala Ser Asn Tyr Tyr Lys Gly Glu Asn Phe Arg Arg Gln Tyr Asp 
                 405                410                415
Glu Phe Tyr Leu Ala Glu Val Ala Phe Thr Val Leu Phe Asp Leu Glu 
             420                425                430
Ala Leu Leu Lys Ile Trp Cys Leu Gly Phe Thr Gly Tyr Ile Ser Ser 
         435                440                445
Ser Leu His Lys Phe Glu Leu Leu Leu Val Ile Gly Thr Thr Leu His 
     450                455                460
Val Tyr Pro Asp Leu Tyr His Ser Gln Phe Thr Tyr Phe Gln Val Leu 
 465                470                475                480
Arg Val Val Arg Leu Ile Lys Ile Ser Pro Ala Leu Glu Asp Phe Val 
                 485                490                495
Tyr Lys Ile Phe Gly Pro Gly Lys Lys Leu Gly Ser Leu Val Val Phe 
             500                505                510
Thr Ala Ser Leu Leu Ile Val Met Ser Ala Ile Ser Leu Gln Met Phe 
         515                520                525
Cys Phe Val Glu Glu Leu Asp Arg Phe Thr Thr Phe Pro Arg Ala Phe 
     530                535                540
Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val Met 
 545                550                555                560
Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Leu Val Ala 
                 565                570                575
Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu Ser 
             580                585                590
Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp Leu 
         595                600                605
Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr Lys 
     610                615                620
Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn Arg 
 625                630                635                640
Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val Pro 
                 645                650                655
Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln Gln 
             660                665                670
Asp Thr Cys Cys Leu Phe Arg Ile Leu Pro Ser Thr Ser Ser Ser Ser 
         675                680                685
Cys Asp Asn Pro Lys Arg Pro Thr Val Glu Asp Asn Lys Tyr Ile Asp 
     690                695                700
Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu Leu 
 705                710                715                720
Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg Gln 
                 725                730                735
Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg Ser 
             740                745                750
Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu Arg 
         755                760                765
His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu Thr 
     770                775                780
Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln Arg 
 785                790                795                800
Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala Glu 
                 805                810                815
Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro Tyr 
             820                825                830
Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg Asn 
         835                840                845
Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr Asp 
     850                855                860
Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr Asp 
 865                870                875                880
Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Thr Val Thr 
                 885                890                895
Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg Val 
             900                905                910
Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile Phe 
         915                920                925
Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe Phe 
     930                935                940
Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile Phe 
 945                950                955                960
Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn Val 
                 965                970                975
Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu Arg 
             980                985                990
Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val Arg 
         995                1000                1005
Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu Leu 
     1010                1015                1020
Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe Ala 
 1025                1030                1035                1040
Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu Asp 
                 1045                1050                1055
Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu Asn 
             1060                1065                1070
Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro Arg 
         1075                1080                1085
Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn Ala 
     1090                1095                1100
Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu Val 
 1105                1110                1115                1120
Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr Ile 
                 1125                1130                1135
His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe Val 
             1140                1145                1150
Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu Leu 
         1155                1160                1165
Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys Ile 
     1170                1175                1180
Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe Arg 
 1185                1190                1195                1200
Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr Ile 
                 1205                1210                1215
Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp Asp 
             1220                1225                1230
Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val Phe 
         1235                1240                1245
Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met Ser 
     1250                1255                1260
Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu Val 
 1265                1270                1275                1280
Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu Asn 
                 1285                1290                1295
Ala Tyr Thr Tyr Met Met Gly Ala Cys Val Ile Val Phe Arg Phe Phe 
             1300                1305                1310
Ser Ile Cys Gly Lys His Val Thr Leu Lys Met Leu Leu Leu Thr Val 
         1315                1320                1325
Val Val Ser Met Tyr Lys Ser Phe Phe Ile Ile Val Gly Met Phe Leu 
     1330                1335                1340
Leu Leu Leu Cys Tyr Ala Phe Ala Gly Val Val Leu Phe Gly Thr Val 
 1345                1350                1355                1360
Lys Tyr Gly Glu Asn Ile Asn Arg His Ala Asn Phe Ser Ser Ala Gly 
                 1365                1370                1375
Lys Ala Ile Thr Val Leu Phe Arg Ile Val Thr Gly Glu Asp Trp Asn 
             1380                1385                1390
Lys Ile Met His Asp Cys Met Val Gln Pro Pro Phe Cys Thr Pro Asp 
         1395                1400                1405
Glu Phe Thr Tyr Trp Ala Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu 
     1410                1415                1420
Met Tyr Phe Cys Ser Phe Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn 
 1425                1430                1435                1440
Leu Leu Val Ala Ile Ile Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr 
                 1445                1450                1455
Glu Glu Asp Gln Leu Leu Ser Tyr Asn Asp Leu Arg His Phe Gln Ile 
             1460                1465                1470
Ile Trp Asn Met Val Asp Asp Asn Glu Arg Cys Asp Pro Thr Phe Arg 
         1475                1480                1485
Val Lys Phe Leu Leu Arg Leu Leu Arg Gly Arg Leu Glu Val Asp Leu 
     1490                1495                1500
Asp Lys Asp Lys Leu Leu Phe Lys His Met Cys Tyr Glu Met Glu Arg 
 1505                1510                1515                1520
Leu His Asn Gly Gly Asp Val Thr Phe His Asp Val Leu Ser Met Leu 
                 1525                1530                1535
Ser Tyr Arg Ser Val Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu Leu 
             1540                1545                1550
Leu Ala Arg Glu Gln Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala Lys 
         1555                1560                1565
Gln Thr Ile Arg Met Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg Ala 
     1570                1575                1580
Lys Gln Gln Gln Ser Cys Ser Ile Ile His Ser Leu Arg Glu Ser Gln 
 1585                1590                1595                1600
Gln Gln Glu Leu Ser Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr Thr 
                 1605                1610                1615
Gln Pro Ser Glu Asp Thr Asn Ala Asn Ser Gln Asp His Asn Thr Gln 
             1620                1625                1630
Pro Glu Ser Ser Ser Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser Asp 
         1635                1640                1645
Arg Gly Gly Ser Arg Gln Asp Ala Ala Asp Thr Gly Lys Pro Gln Arg 
     1650                1655                1660
Lys Ile Gly Gln Trp Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser His 
 1665                1670                1675                1680
Ser Val Ser Ser Val Asn Leu Arg Phe Gly Gly Arg Thr Thr Met Lys 
                 1685                1690                1695
Ser Val Val Cys Lys Met Asn Pro Met Pro Asp Thr Ala Ser Cys Gly 
             1700                1705                1710
Ser Glu Val Lys Lys Trp Trp Thr Arg Gln Leu Thr Val Glu Ser Asp 
         1715                1720                1725
Glu Ser Gly Asp Asp Leu Leu Asp Ile 
     1730                1735



<210> 1104
<211> 380
<212> DNA
<213> Homo sapiens
<308> AW295007
<400> 1104

ttttttttt  tttttatca  agagatcat  gaagcttta  tagccttta  acaccagca  60
gttgattag  gacacagta  cagggggtc  ccggttctt  tcttctttg  ctccatgtc  120
tctttctta  tgtcccaga  caaggctgt  gaaaattcc  atacattct  actccacta  180
agtgacaat  tgatcttcc  aagtagaga  aacagcgga  gctaatggg  gagctcgtc  240
gtaatggac  cttgcttaa  attttagtg  ctgcggtct  cttttccag  aggttcctt  300
ccctgatgc  gaaaacaga  ttgcgaagt  tttggtcga  gtatttgtt  tcctcaatt  360
ctgaacgtt  ggagtggtcg  380



<210> 1105
<211> 1172
<212> PRT
<213> Homo sapiens
<308> CAC40696
<400> 1105

Phe Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val 
  1               5                  10                  15
Met Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Val Val 
             20                  25                  30
Ala Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu 
         35                  40                  45
Ser Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp 
     50                  55                  60
Leu Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr 
 65                  70                  75                  80
Lys Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn 
                 85                  90                  95
Arg Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val 
             100                105                110
Pro Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln 
         115                120                125
Gln Asp Thr Cys Cys Leu Leu Arg Ser Leu Pro Thr Thr Ser Ser Ser 
     130                135                140
Ser Cys Asp His Ser Lys Arg Ser Ala Ile Glu Asp Asn Lys Tyr Ile 
 145                150                155                160
Asp Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu 
                 165                170                175
Leu Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg 
             180                185                190
Gln Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg 
         195                200                205
Ser Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu 
     210                215                220
Arg His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu 
 225                230                235                240
Thr Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln 
                 245                250                255
Arg Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala 
             260                265                270
Glu Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro 
         275                280                285
Tyr Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg 
     290                295                300
Asn Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr 
 305                310                315                320
Asp Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr 
                 325                330                335
Asp Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Ile Val 
             340                345                350
Thr Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg 
         355                360                365
Val Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile 
     370                375                380
Phe Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe 
 385                390                395                400
Phe Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile 
                 405                410                415
Phe Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn 
             420                425                430
Val Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu 
         435                440                445
Arg Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val 
     450                455                460
Arg Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu 
 465                470                475                480
Leu Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe 
                 485                490                495
Ala Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu 
             500                505                510
Asp Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu 
         515                520                525
Asn Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro 
     530                535                540
Arg Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn 
 545                550                555                560
Ala Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu 
                 565                570                575
Val Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr 
             580                585                590
Ile His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe 
         595                600                605
Val Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu 
     610                615                620
Leu Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys 
 625                630                635                640
Ile Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe 
                 645                650                655
Arg Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr 
             660                665                670
Ile Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp 
         675                680                685
Asp Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val 
     690                695                700
Phe Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met 
 705                710                715                720
Ser Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu 
                 725                730                735
Val Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu 
             740                745                750
Val Thr Leu Lys Met Leu Leu Leu Thr Val Val Val Ser Met Tyr Lys 
         755                760                765
Ser Phe Phe Ile Ile Val Gly Met Phe Leu Leu Leu Leu Cys Tyr Ala 
     770                775                780
Phe Ala Gly Val Val Leu Phe Gly Thr Val Lys Tyr Gly Glu Asn Ile 
 785                790                795                800
Asn Arg His Ala Asn Phe Ser Ser Ala Gly Lys Ala Ile Thr Val Leu 
                 805                810                815
Phe Arg Ile Val Thr Gly Glu Asp Trp Asn Lys Ile Met His Asp Cys 
             820                825                830
Met Val Gln Pro Pro Phe Cys Thr Pro Asp Glu Phe Thr Tyr Trp Ala 
         835                840                845
Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu Met Tyr Phe Cys Ser Phe 
     850                855                860
Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn Leu Leu Val Ala Ile Ile 
 865                870                875                880
Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr Glu Glu Asp Gln Leu Leu 
                 885                890                895
Ser Tyr Asn Asp Leu Arg His Phe Gln Ile Ile Trp Asn Met Val Asp 
             900                905                910
Asp Lys Arg Glu Gly Val Ile Pro Thr Phe Arg Val Lys Phe Leu Leu 
         915                920                925
Arg Leu Leu Arg Gly Arg Leu Glu Val Asp Leu Asp Lys Asp Lys Leu 
     930                935                940
Leu Phe Lys His Met Cys Tyr Glu Met Glu Arg Leu His Asn Gly Gly 
 945                950                955                960
Asp Val Thr Phe His Asp Val Leu Ser Met Leu Ser Tyr Arg Ser Val 
                 965                970                975
Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu Leu Leu Ala Arg Glu Gln 
             980                985                990
Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala Lys Gln Thr Ile Arg Met 
         995                1000                1005
Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg Ala Lys Gln Gln Gln Ser 
     1010                1015                1020
Cys Ser Ile Ile His Ser Leu Arg Glu Ser Gln Gln Gln Glu Leu Ser 
 1025                1030                1035                1040
Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr Thr Gln Pro Ser Glu Asp 
                 1045                1050                1055
Thr Asn Ala Asn Ser Gln Asp Asn Ser Met Gln Pro Glu Thr Ser Ser 
             1060                1065                1070
Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser Asp Arg Gly Gly Ser Arg 
         1075                1080                1085
Gln Asp Ala Ala Asp Ala Gly Lys Pro Gln Arg Lys Phe Gly Gln Trp 
     1090                1095                1100
Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser His Ser Val Ser Ser Val 
 1105                1110                1115                1120
Asn Leu Arg Phe Gly Gly Arg Thr Thr Met Lys Ser Val Val Cys Lys 
                 1125                1130                1135
Met Asn Pro Met Thr Asp Ala Ala Ser Cys Gly Ser Glu Val Lys Lys 
             1140                1145                1150
Trp Trp Thr Arg Gln Leu Thr Val Glu Ser Asp Glu Ser Gly Asp Asp 
         1155                1160                1165
Leu Leu Asp Ile 
     1170



<210> 1106
<211> 6779
<212> DNA
<213> Rattus norvegicus
<308> AF078779
<400> 1106

cgggcgcgc  gcggttaca  actgtggtt  tgtacctgc  tcccacagc  aacttcacc  60
tgctcaaaa  aaagcagag  tccagggtg  aagcccagc  agtaactga  tttggtcct  120
acgaatctc  gtcagacaa  gctgacata  tctggatta  taagccatg  gtgcactct  180
tgctgcgca  ctgtgccat  atcagcgtc  tctcagtgt  catgaacac  cctatgacc  240
tcgagcact  tcctcccct  cagtatgtg  ccttcaccc  ggacacttt  ctgatgttt  300
tctacactg  agagatgat  gcaaagatg  acatacggg  aattgtcaa  ggcgatagc  360
cctatgtga  ggaccgctg  tgtgttttt  atggattca  ggtcttttg  ctttgggtt  420
ctctcgtgt  acaggtgtt  gaaatagct  acatagttg  tcagatgtc  ccttggggc  480
tgctgcgga  cccacggcc  ctcattatg  tccgggctt  caggattta  ttccgattc  540
aactgccaa  gacccgaat  acaaacatt  taaagcggt  aggagaaca  atatggagt  600
tctcaatct  cctcctctt  ttccttctt  tgtatggga  tttaggagt  cagatgttt  660
gaacattta  ctaccactg  gtagtcaat  acacaaagc  agggaatgt  acctggaat  720
gcttagcta  cccagatac  cactgctcg  cagagctag  agaaggcta  cagtgcccc  780
caggattta  atgcatgga  ctggaagac  tgggactta  caggcaaga  ctgggctac  840
gtggcttta  tgagatagg  acgagtata  tcacagtct  tgaggcttc  tctcaggaa  900
gctgggtat  cctcatgta  agagcaatc  acagtttcc  ccgttggcg  tcctacttc  960
acttcatca  gctgatttt  ttccttgcc  ggcttgtca  gaatgtgtt  attgctgtc  1020
tcattgaga  atttgcaga  atcagagta  aatttcaac  aatgtgggg  actcggagc  1080
gcacaactt  cactgccac  acgcagatg  tccatgaag  tgctgccgg  ggctggcag  1140
tggtagctg  ggatgtcaa  aagccccag  gacgtgccc  agcctgcct  cagaaaatg  1200
tgcggtcat  agttttcca  atgtttatc  tgagcatgg  gactgtgga  gtaatagtt  1260
ctgccagca  ctactacaa  ggagagaac  tcagaaggc  gtatgacga  ttctacctt  1320
cagaggtgg  ttttacagt  ctttttgat  tggaagcac  tctgaagat  tggtgtttg  1380
ggtttactg  ctacatcag  tcatctctc  acaagtttg  actacttct  gttattggg  1440
caactctcc  tgtataccc  gatctttat  attctcaat  tacctactt  caggttctt  1500
gggtagtcc  gcttattaa  atttcccca  cattggaag  ttttgtgta  aagatattt  1560
gtcccggga  aaaacttgg  agcttggtg  tgttcactg  cagtctcct  atagttatg  1620
ccgccatca  tttgcagat  ttctgcttc  tcgaagaac  ggacagatt  accacattt  1680
caagggcat  tatgtccat  ttccagatc  tcacccagg  aggatgggt  gatgtgatg  1740
atcagactc  gaatgctgt  gggcatatg  gggctccac  ggttgccat  tatttcatc  1800
tctaccatc  ctttgcaac  ctgatcctc  tgagtttgt  tgttgctgt  attttggac  1860
acttagaac  tgatgaaga  ctaaagaag  tcaaacaat  aaaacaaag  gaagcgaac  1920
cagatacca  agaaaaact  cctttgcgc  tgagaatct  cgaaaaatt  ccaaacaga  1980
cgcaaatgg  gaaaatctc  aaacttcct  cagatttta  agttcctaa  atcagggaa  2040
gcttcatga  gcagttcat  gaccgccag  aacaggaca  ctgctgtct  ttcagaatt  2100
tcccctcta  ctcttcctc  tcctgtgac  accccaagc  gcccacagt  gaagacaac  2160
aatacattg  tcaaaaact  cgcaagtct  ttttcagca  aagggcaag  aaccttctg  2220
aaaaggaga  cgcagtcac  aaaatctta  gagcttgca  tcgacagcg  atgctgagc  2280
gatcattcg  ggggcagcc  gcaaaggag  ggtcgatcc  cagcgtgca  catcacatc  2340
gccaggagc  caggtcact  agacatgga  ccaacagcc  gaggatcag  aggggcaaa  2400
ctcttgaaa  gttaactca  gatcattcc  atacggtgc  ctacagaaa  gcacaaaga  2460
aagacagtg  aataaagat  atccaggag  agaaggagc  agcagagat  aaaaggaag  2520
tgcaagaag  ggagctgcg  gagaaccac  catactttg  caagcctct  ttcatcgtg  2580
gtcgagaac  caggttcag  aacttctgc  gcgtggtgg  tcgagcacg  ttcaatgca  2640
ccaaaacag  ccctgtcac  ggagctgtg  aaaatacaa  gtaccacca  ctttatgat  2700
tgctgggac  tgtcaccta  ctggactgg  tcatgatca  tgtaaccat  tgctcttgc  2760
tttctatga  gttcgaatc  cccttccgg  gagtcatgc  tgcacccac  ttacagatc  2820
ctgaatatg  gtttgtgat  ttcatgagc  ttgagctta  tctgaagat  atggcagat  2880
gcttgtttt  cactccaac  gctgtcatc  gggactttg  tggcgtcat  gacatattt  2940
tctatcttg  gagcttgat  tttctttgt  ggatgcctc  aaatgtgcc  gctgagtca  3000
gagcccagc  cctgatggt  cttcggtgc  taagacctc  tcggatatt  aaactggtg  3060
cacaaatga  gaaagttgt  cgagaactt  tcagtggtt  caaggaaat  tttttggtc  3120
ccattctgt  gctgacact  atgcttgtt  ttgcaagct  tggtgttca  ctctttgcc  3180
gaaagctag  caagtgcaa  gaccccaac  ttatcagaa  ggaagactg  aacggcatc  3240
tcagaatta  tgtaagtgt  tccaagaac  taaatttaa  actaagacc  ggagagaaa  3300
aacctggat  ttgggtgcc  cgtgtttgg  caaatcctc  taactttaa  tttgacaat  3360
tgggaaatg  tatgctggc  ttgtttgaa  ttctgtcct  gaaaggctg  gtagaagtg  3420
gagatgtca  tattcatcg  gtggggccg  tccatggaa  ctatattca  gttttcgta  3480
tcctgggtt  catgattgg  ctgactctt  ttgtcggtg  agttattgc  aacttcaat  3540
aaaacaagg  gacagccct  ctgacggta  atcagagaa  atgggaaga  ctcaagagc  3600
gattgaaga  cgcacagcc  cttcatctc  cacctcggc  ggataatga  ggatttaga  3660
ctaaaatgt  tgacataac  cagcatccg  tttttaaaa  gacaattgc  ttgctggtt  3720
tggcccagt  tgtgttgct  tctgtcaag  gggatgttg  ggatcctgt  acagttcct  3780
tggcaacca  gtcggtcgt  ttcaccttc  tctttgtct  agaggttac  atgaagatc  3840
tagcaatgt  accagctgg  ttctggcaa  gcagaagaa  ccgatatga  ctcttggtg  3900
cgtctcttg  tgttgtgtg  gtggtgctc  attttgctc  gctgaatgc  tacacctac  3960
tgatgggag  ctgtgtgat  gtctttaga  ttttctcca  ctgtggaaa  catgtgaca  4020
taaagatgc  ccttttgac  gtggttgtc  gcatgtaca  gagcttctt  atcatcgta  4080
gaatgtttc  cttgctgct  tgctatgcc  ttgctgggg  ggttctgtt  ggcactgta  4140
agtatggag  gaacattaa  aggcatgcc  atttttctt  agctggcaa  gccattact  4200
tattgttcc  aattgtcac  ggggaagac  ggaataaga  tatgcatga  tgtatggtt  4260
agcctccat  ttgtactcc  gatgaattt  catattggg  aacagactg  ggcaattat  4320
caggggcac  tatgtactt  tgctcattc  atgtcatca  cgcctacat  atgctgaat  4380
tacttgtag  cataattgt  gagaatttc  ctttgtttt  ttccactga  gaggaccag  4440
ttttgagtt  caatgatct  cgccatttt  aaatcatat  gaatatggt  gatgataac  4500
agaggtgtg  tcccacctt  cgagtgaag  tcctgctac  gctactgcg  gggaggcta  4560
aagtggacc  tgataaaga  aagctcctg  ttaagcaca  gtgctatga  atggagagg  4620
tgcacaatg  tggtgatgt  accttccat  atgtcttga  catgctgtc  taccgctct  4680
tagacatca  gaagagcct  cagctagag  aactgctgg  aagggagca  ctggagtac  4740
ccatagagg  ggaggtggc  aagcagact  ttcgcatgt  gctgaagaa  tgcttaaaa  4800
gcatccggg  taaacagca  cagtcatgc  gcatcatcc  cagcctgag  gagagccag  4860
agcaagagt  gagccgatt  ctgaatcct  ccagcattg  gaccaccca  ccaagcgaa  4920
ataccaacg  caacagcca  gaccacaat  cgcaacctg  gtcaagcag  cagcagcag  4980
tcttgagcc  tactctgtc  gacagagga  gaagtcgac  ggatgcagc  gatactggg  5040
aaccccaaa  aaagattgg  caatggcgt  tgccctcag  tcccaaacc  ataagccat  5100
ctgtgtctt  ggttaacct  cggtttgga  gaaggacaa  aatgaagtc  gtggtgtgc  5160
agatgaacc  catgccaga  acagcttcc  gtggctccg  agttaaaaa  tggtggacc  5220
gacagctga  tgtggagag  gacgagagt  gagatgacc  cctagatat  tagagggga  5280
gcaaagcat  gggatttat  gggtgaaaa  cactgccta  tctcttgtt  tatctctga  5340
agagcaaac  gtagttgcc  aaccctaaa  ttcacccga  catggcatt  tcagaatta  5400
cttttgttc  tttattgga  tggtccctc  aagagtatg  agtttcaga  tactctcat  5460
tattaaaga  aatctgggg  ttgggatgt  agtcagtga  agaccactt  tccaaccta  5520
gaaaacccg  gtgtttaaa  cccagaaat  caagaaaag  aggaaaata  gtataatgc  5580
gtattgata  tattagaag  tgcatcaat  gtagatgtg  attaaatat  catgtattc  5640
gtctgtgta  gataagctg  actcacctg  actcctgta  tttgttact  ctcctctca  5700
agagtgcta  gcccatact  gcccatatt  atagtacag  agttgtagc  ctagttcac  5760
tttttttcc  atttccaat  gaaatactt  ccttgggag  aattattta  gattgatct  5820
aaaaggtca  tcatgctaa  atgacagca  cttcaaaac  acagattct  gatttttaa  5880
aacattcct  ttctcatat  atttaaaaa  tatgcctga  gttaaaaaa  ttagacaat  5940
tgatttttt  tttcaagta  tctaattga  ctgtggcct  cttccaaga  agttatata  6000
gtaggtccc  tgtaaagga  ctggctata  atataattg  tatataaca  acctgtagg  6060
atattattc  tggacttga  gagacaaaa  tattttgaa  tctttaaaa  ccctttaaa  6120
aactgagtt  ataaaaaaa  aataaaagt  ttggagtca  catagctaa  agtttacac  6180
tgagactta  tgtggactt  atggcttat  cttgctgta  ccattttgc  atgaatcag  6240
aggaacatt  tgggttggc  ttaatacac  attactatg  agattgaaa  taatttccc  6300
gcttccaga  ttatctatt  aaataataa  agaagggtg  caaaacttc  ctctaaacc  6360
cattgggaa  accacaaca  aattatatt  tcccacaca  caatgctcc  ggttctctg  6420
gaaaagtgg  aatataaaa  tattggaaa  tattgatgg  ccctggctg  gcagagtct  6480
ccctgagtt  tcattatca  ttgcatatt  gatgatcag  ttattttaa  agattgagt  6540
tgtaaaaat  ccctgatgc  taggttgct  tatgatatc  ttttgtcta  ttaaccttc  6600
tcaaatagc  aaacattgt  tccttccta  acagaagat  tgatataat  tgcccatct  6660
ctgctttta  gattacttg  gactattag  taataggca  ttcaagttc  tgccgccaa  6720
gggcctttt  attgggttt  atgtttggt  agaatttga  ttttggata  aaaagccgg  6779



<210> 1107
<211> 1737
<212> PRT
<213> Rattus norvegicus
<308> AAC68885
<400> 1107

Met Leu Lys Arg Lys Gln Ser Ser Arg Val Glu Ala Gln Pro Val Thr 
  1               5                  10                  15
Asp Phe Gly Pro Asp Glu Ser Leu Ser Asp Asn Ala Asp Ile Leu Trp 
             20                  25                  30
Ile Asn Lys Pro Trp Val His Ser Leu Leu Arg Ile Cys Ala Ile Ile 
         35                  40                  45
Ser Val Ile Ser Val Cys Met Asn Thr Pro Met Thr Phe Glu His Tyr 
     50                  55                  60
Pro Pro Leu Gln Tyr Val Thr Phe Thr Leu Asp Thr Leu Leu Met Phe 
 65                  70                  75                  80
Leu Tyr Thr Ala Glu Met Ile Ala Lys Met His Ile Arg Gly Ile Val 
                 85                  90                  95
Lys Gly Asp Ser Ser Tyr Val Lys Asp Arg Trp Cys Val Phe Asp Gly 
             100                105                110
Phe Met Val Phe Cys Leu Trp Val Ser Leu Val Leu Gln Val Phe Glu 
         115                120                125
Ile Ala Asp Ile Val Asp Gln Met Ser Pro Trp Gly Met Leu Arg Ile 
     130                135                140
Pro Arg Pro Leu Ile Met Ile Arg Ala Phe Arg Ile Tyr Phe Arg Phe 
 145                150                155                160
Glu Leu Pro Arg Thr Arg Ile Thr Asn Ile Leu Lys Arg Ser Gly Glu 
                 165                170                175
Gln Ile Trp Ser Val Ser Ile Phe Leu Leu Phe Phe Leu Leu Leu Tyr 
             180                185                190
Gly Ile Leu Gly Val Gln Met Phe Gly Thr Phe Thr Tyr His Cys Val 
         195                200                205
Val Asn Asp Thr Lys Pro Gly Asn Val Thr Trp Asn Ser Leu Ala Ile 
     210                215                220
Pro Asp Thr His Cys Ser Pro Glu Leu Glu Glu Gly Tyr Gln Cys Pro 
 225                230                235                240
Pro Gly Phe Lys Cys Met Asp Leu Glu Asp Leu Gly Leu Ser Arg Gln 
                 245                250                255
Glu Leu Gly Tyr Ser Gly Phe Asn Glu Ile Gly Thr Ser Ile Phe Thr 
             260                265                270
Val Tyr Glu Ala Ser Ser Gln Glu Gly Trp Val Phe Leu Met Tyr Arg 
         275                280                285
Ala Ile Asp Ser Phe Pro Arg Trp Arg Ser Tyr Phe Tyr Phe Ile Thr 
     290                295                300
Leu Ile Phe Phe Leu Ala Trp Leu Val Lys Asn Val Phe Ile Ala Val 
 305                310                315                320
Ile Ile Glu Thr Phe Ala Glu Ile Arg Val Gln Phe Gln Gln Met Trp 
                 325                330                335
Gly Thr Arg Ser Ser Thr Thr Ser Thr Ala Thr Thr Gln Met Phe His 
             340                345                350
Glu Asp Ala Ala Gly Gly Trp Gln Leu Val Ala Val Asp Val Asn Lys 
         355                360                365
Pro Gln Gly Arg Ala Pro Ala Cys Leu Gln Lys Met Met Arg Ser Ser 
     370                375                380
Val Phe His Met Phe Ile Leu Ser Met Val Thr Val Asp Val Ile Val 
 385                390                395                400
Ala Ala Ser Asn Tyr Tyr Lys Gly Glu Asn Phe Arg Arg Gln Tyr Asp 
                 405                410                415
Glu Phe Tyr Leu Ala Glu Val Ala Phe Thr Val Leu Phe Asp Leu Glu 
             420                425                430
Ala Leu Leu Lys Ile Trp Cys Leu Gly Phe Thr Gly Tyr Ile Ser Ser 
         435                440                445
Ser Leu His Lys Phe Glu Leu Leu Leu Val Ile Gly Thr Thr Leu His 
     450                455                460
Val Tyr Pro Asp Leu Tyr His Ser Gln Phe Thr Tyr Phe Gln Val Leu 
 465                470                475                480
Arg Val Val Arg Leu Ile Lys Ile Ser Pro Ala Leu Glu Asp Phe Val 
                 485                490                495
Tyr Lys Ile Phe Gly Pro Gly Lys Lys Leu Gly Ser Leu Val Val Phe 
             500                505                510
Thr Ala Ser Leu Leu Ile Val Met Ser Ala Ile Ser Leu Gln Met Phe 
         515                520                525
Cys Phe Val Glu Glu Leu Asp Arg Phe Thr Thr Phe Pro Arg Ala Phe 
     530                535                540
Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val Met 
 545                550                555                560
Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Leu Val Ala 
                 565                570                575
Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu Ser 
             580                585                590
Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp Leu 
         595                600                605
Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr Lys 
     610                615                620
Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn Arg 
 625                630                635                640
Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val Pro 
                 645                650                655
Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln Gln 
             660                665                670
Asp Thr Cys Cys Leu Phe Arg Ile Leu Pro Ser Thr Ser Ser Ser Ser 
         675                680                685
Cys Asp Asn Pro Lys Arg Pro Thr Val Glu Asp Asn Lys Tyr Ile Asp 
     690                695                700
Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu Leu 
 705                710                715                720
Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg Gln 
                 725                730                735
Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg Ser 
             740                745                750
Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu Arg 
         755                760                765
His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu Thr 
     770                775                780
Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln Arg 
 785                790                795                800
Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala Glu 
                 805                810                815
Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro Tyr 
             820                825                830
Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg Asn 
         835                840                845
Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr Asp 
     850                855                860
Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr Asp 
 865                870                875                880
Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Thr Val Thr 
                 885                890                895
Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg Val 
             900                905                910
Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile Phe 
         915                920                925
Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe Phe 
     930                935                940
Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile Phe 
 945                950                955                960
Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn Val 
                 965                970                975
Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu Arg 
             980                985                990
Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val Arg 
         995                1000                1005
Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu Leu 
     1010                1015                1020
Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe Ala 
 1025                1030                1035                1040
Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu Asp 
                 1045                1050                1055
Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu Asn 
             1060                1065                1070
Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro Arg 
         1075                1080                1085
Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn Ala 
     1090                1095                1100
Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu Val 
 1105                1110                1115                1120
Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr Ile 
                 1125                1130                1135
His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe Val 
             1140                1145                1150
Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu Leu 
         1155                1160                1165
Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys Ile 
     1170                1175                1180
Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe Arg 
 1185                1190                1195                1200
Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr Ile 
                 1205                1210                1215
Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp Asp 
             1220                1225                1230
Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val Phe 
         1235                1240                1245
Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met Ser 
     1250                1255                1260
Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu Val 
 1265                1270                1275                1280
Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu Asn 
                 1285                1290                1295
Ala Tyr Thr Tyr Met Met Gly Ala Cys Val Ile Val Phe Arg Phe Phe 
             1300                1305                1310
Ser Ile Cys Gly Lys His Val Thr Leu Lys Met Leu Leu Leu Thr Val 
         1315                1320                1325
Val Val Ser Met Tyr Lys Ser Phe Phe Ile Ile Val Gly Met Phe Leu 
     1330                1335                1340
Leu Leu Leu Cys Tyr Ala Phe Ala Gly Val Val Leu Phe Gly Thr Val 
 1345                1350                1355                1360
Lys Tyr Gly Glu Asn Ile Asn Arg His Ala Asn Phe Ser Ser Ala Gly 
                 1365                1370                1375
Lys Ala Ile Thr Val Leu Phe Arg Ile Val Thr Gly Glu Asp Trp Asn 
             1380                1385                1390
Lys Ile Met His Asp Cys Met Val Gln Pro Pro Phe Cys Thr Pro Asp 
         1395                1400                1405
Glu Phe Thr Tyr Trp Ala Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu 
     1410                1415                1420
Met Tyr Phe Cys Ser Phe Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn 
 1425                1430                1435                1440
Leu Leu Val Ala Ile Ile Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr 
                 1445                1450                1455
Glu Glu Asp Gln Leu Leu Ser Tyr Asn Asp Leu Arg His Phe Gln Ile 
             1460                1465                1470
Ile Trp Asn Met Val Asp Asp Asn Glu Arg Cys Asp Pro Thr Phe Arg 
         1475                1480                1485
Val Lys Phe Leu Leu Arg Leu Leu Arg Gly Arg Leu Glu Val Asp Leu 
     1490                1495                1500
Asp Lys Asp Lys Leu Leu Phe Lys His Met Cys Tyr Glu Met Glu Arg 
 1505                1510                1515                1520
Leu His Asn Gly Gly Asp Val Thr Phe His Asp Val Leu Ser Met Leu 
                 1525                1530                1535
Ser Tyr Arg Ser Val Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu Leu 
             1540                1545                1550
Leu Ala Arg Glu Gln Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala Lys 
         1555                1560                1565
Gln Thr Ile Arg Met Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg Ala 
     1570                1575                1580
Lys Gln Gln Gln Ser Cys Ser Ile Ile His Ser Leu Arg Glu Ser Gln 
 1585                1590                1595                1600
Gln Gln Glu Leu Ser Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr Thr 
                 1605                1610                1615
Gln Pro Ser Glu Asp Thr Asn Ala Asn Ser Gln Asp His Asn Thr Gln 
             1620                1625                1630
Pro Glu Ser Ser Ser Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser Asp 
         1635                1640                1645
Arg Gly Gly Ser Arg Gln Asp Ala Ala Asp Thr Gly Lys Pro Gln Arg 
     1650                1655                1660
Lys Ile Gly Gln Trp Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser His 
 1665                1670                1675                1680
Ser Val Ser Ser Val Asn Leu Arg Phe Gly Gly Arg Thr Thr Met Lys 
                 1685                1690                1695
Ser Val Val Cys Lys Met Asn Pro Met Pro Asp Thr Ala Ser Cys Gly 
             1700                1705                1710
Ser Glu Val Lys Lys Trp Trp Thr Arg Gln Leu Thr Val Glu Ser Asp 
         1715                1720                1725
Glu Ser Gly Asp Asp Leu Leu Asp Ile 
     1730                1735



<210> 1108
<211> 380
<212> DNA
<213> Homo sapiens
<308> AW295007
<400> 1108

ttttttttt  tttttatca  agagatcat  gaagcttta  tagccttta  acaccagca  60
gttgattag  gacacagta  cagggggtc  ccggttctt  tcttctttg  ctccatgtc  120
tctttctta  tgtcccaga  caaggctgt  gaaaattcc  atacattct  actccacta  180
agtgacaat  tgatcttcc  aagtagaga  aacagcgga  gctaatggg  gagctcgtc  240
gtaatggac  cttgcttaa  attttagtg  ctgcggtct  cttttccag  aggttcctt  300
ccctgatgc  gaaaacaga  ttgcgaagt  tttggtcga  gtatttgtt  tcctcaatt  360
ctgaacgtt  ggagtggtcg  380



<210> 1109
<211> 1172
<212> PRT
<213> Homo sapiens
<308> CAC40696
<400> 1109

Phe Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val 
  1               5                  10                  15
Met Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Val Val 
             20                  25                  30
Ala Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu 
         35                  40                  45
Ser Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp 
     50                  55                  60
Leu Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr 
 65                  70                  75                  80
Lys Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn 
                 85                  90                  95
Arg Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val 
             100                105                110
Pro Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln 
         115                120                125
Gln Asp Thr Cys Cys Leu Leu Arg Ser Leu Pro Thr Thr Ser Ser Ser 
     130                135                140
Ser Cys Asp His Ser Lys Arg Ser Ala Ile Glu Asp Asn Lys Tyr Ile 
 145                150                155                160
Asp Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu 
                 165                170                175
Leu Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg 
             180                185                190
Gln Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg 
         195                200                205
Ser Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu 
     210                215                220
Arg His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu 
 225                230                235                240
Thr Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln 
                 245                250                255
Arg Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala 
             260                265                270
Glu Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro 
         275                280                285
Tyr Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg 
     290                295                300
Asn Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr 
 305                310                315                320
Asp Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr 
                 325                330                335
Asp Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Ile Val 
             340                345                350
Thr Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg 
         355                360                365
Val Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile 
     370                375                380
Phe Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe 
 385                390                395                400
Phe Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile 
                 405                410                415
Phe Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn 
             420                425                430
Val Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu 
         435                440                445
Arg Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val 
     450                455                460
Arg Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu 
 465                470                475                480
Leu Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe 
                 485                490                495
Ala Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu 
             500                505                510
Asp Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu 
         515                520                525
Asn Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro 
     530                535                540
Arg Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn 
 545                550                555                560
Ala Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu 
                 565                570                575
Val Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr 
             580                585                590
Ile His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe 
         595                600                605
Val Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu 
     610                615                620
Leu Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys 
 625                630                635                640
Ile Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe 
                 645                650                655
Arg Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr 
             660                665                670
Ile Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp 
         675                680                685
Asp Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val 
     690                695                700
Phe Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met 
 705                710                715                720
Ser Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu 
                 725                730                735
Val Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu 
             740                745                750
Val Thr Leu Lys Met Leu Leu Leu Thr Val Val Val Ser Met Tyr Lys 
         755                760                765
Ser Phe Phe Ile Ile Val Gly Met Phe Leu Leu Leu Leu Cys Tyr Ala 
     770                775                780
Phe Ala Gly Val Val Leu Phe Gly Thr Val Lys Tyr Gly Glu Asn Ile 
 785                790                795                800
Asn Arg His Ala Asn Phe Ser Ser Ala Gly Lys Ala Ile Thr Val Leu 
                 805                810                815
Phe Arg Ile Val Thr Gly Glu Asp Trp Asn Lys Ile Met His Asp Cys 
             820                825                830
Met Val Gln Pro Pro Phe Cys Thr Pro Asp Glu Phe Thr Tyr Trp Ala 
         835                840                845
Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu Met Tyr Phe Cys Ser Phe 
     850                855                860
Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn Leu Leu Val Ala Ile Ile 
 865                870                875                880
Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr Glu Glu Asp Gln Leu Leu 
                 885                890                895
Ser Tyr Asn Asp Leu Arg His Phe Gln Ile Ile Trp Asn Met Val Asp 
             900                905                910
Asp Lys Arg Glu Gly Val Ile Pro Thr Phe Arg Val Lys Phe Leu Leu 
         915                920                925
Arg Leu Leu Arg Gly Arg Leu Glu Val Asp Leu Asp Lys Asp Lys Leu 
     930                935                940
Leu Phe Lys His Met Cys Tyr Glu Met Glu Arg Leu His Asn Gly Gly 
 945                950                955                960
Asp Val Thr Phe His Asp Val Leu Ser Met Leu Ser Tyr Arg Ser Val 
                 965                970                975
Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu Leu Leu Ala Arg Glu Gln 
             980                985                990
Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala Lys Gln Thr Ile Arg Met 
         995                1000                1005
Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg Ala Lys Gln Gln Gln Ser 
     1010                1015                1020
Cys Ser Ile Ile His Ser Leu Arg Glu Ser Gln Gln Gln Glu Leu Ser 
 1025                1030                1035                1040
Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr Thr Gln Pro Ser Glu Asp 
                 1045                1050                1055
Thr Asn Ala Asn Ser Gln Asp Asn Ser Met Gln Pro Glu Thr Ser Ser 
             1060                1065                1070
Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser Asp Arg Gly Gly Ser Arg 
         1075                1080                1085
Gln Asp Ala Ala Asp Ala Gly Lys Pro Gln Arg Lys Phe Gly Gln Trp 
     1090                1095                1100
Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser His Ser Val Ser Ser Val 
 1105                1110                1115                1120
Asn Leu Arg Phe Gly Gly Arg Thr Thr Met Lys Ser Val Val Cys Lys 
                 1125                1130                1135
Met Asn Pro Met Thr Asp Ala Ala Ser Cys Gly Ser Glu Val Lys Lys 
             1140                1145                1150
Trp Trp Thr Arg Gln Leu Thr Val Glu Ser Asp Glu Ser Gly Asp Asp 
         1155                1160                1165
Leu Leu Asp Ile 
     1170



<210> 1110
<211> 6779
<212> DNA
<213> Rattus norvegicus
<308> AF078779
<400> 1110

cgggcgcgc  gcggttaca  actgtggtt  tgtacctgc  tcccacagc  aacttcacc  60
tgctcaaaa  aaagcagag  tccagggtg  aagcccagc  agtaactga  tttggtcct  120
acgaatctc  gtcagacaa  gctgacata  tctggatta  taagccatg  gtgcactct  180
tgctgcgca  ctgtgccat  atcagcgtc  tctcagtgt  catgaacac  cctatgacc  240
tcgagcact  tcctcccct  cagtatgtg  ccttcaccc  ggacacttt  ctgatgttt  300
tctacactg  agagatgat  gcaaagatg  acatacggg  aattgtcaa  ggcgatagc  360
cctatgtga  ggaccgctg  tgtgttttt  atggattca  ggtcttttg  ctttgggtt  420
ctctcgtgt  acaggtgtt  gaaatagct  acatagttg  tcagatgtc  ccttggggc  480
tgctgcgga  cccacggcc  ctcattatg  tccgggctt  caggattta  ttccgattc  540
aactgccaa  gacccgaat  acaaacatt  taaagcggt  aggagaaca  atatggagt  600
tctcaatct  cctcctctt  ttccttctt  tgtatggga  tttaggagt  cagatgttt  660
gaacattta  ctaccactg  gtagtcaat  acacaaagc  agggaatgt  acctggaat  720
gcttagcta  cccagatac  cactgctcg  cagagctag  agaaggcta  cagtgcccc  780
caggattta  atgcatgga  ctggaagac  tgggactta  caggcaaga  ctgggctac  840
gtggcttta  tgagatagg  acgagtata  tcacagtct  tgaggcttc  tctcaggaa  900
gctgggtat  cctcatgta  agagcaatc  acagtttcc  ccgttggcg  tcctacttc  960
acttcatca  gctgatttt  ttccttgcc  ggcttgtca  gaatgtgtt  attgctgtc  1020
tcattgaga  atttgcaga  atcagagta  aatttcaac  aatgtgggg  actcggagc  1080
gcacaactt  cactgccac  acgcagatg  tccatgaag  tgctgccgg  ggctggcag  1140
tggtagctg  ggatgtcaa  aagccccag  gacgtgccc  agcctgcct  cagaaaatg  1200
tgcggtcat  agttttcca  atgtttatc  tgagcatgg  gactgtgga  gtaatagtt  1260
ctgccagca  ctactacaa  ggagagaac  tcagaaggc  gtatgacga  ttctacctt  1320
cagaggtgg  ttttacagt  ctttttgat  tggaagcac  tctgaagat  tggtgtttg  1380
ggtttactg  ctacatcag  tcatctctc  acaagtttg  actacttct  gttattggg  1440
caactctcc  tgtataccc  gatctttat  attctcaat  tacctactt  caggttctt  1500
gggtagtcc  gcttattaa  atttcccca  cattggaag  ttttgtgta  aagatattt  1560
gtcccggga  aaaacttgg  agcttggtg  tgttcactg  cagtctcct  atagttatg  1620
ccgccatca  tttgcagat  ttctgcttc  tcgaagaac  ggacagatt  accacattt  1680
caagggcat  tatgtccat  ttccagatc  tcacccagg  aggatgggt  gatgtgatg  1740
atcagactc  gaatgctgt  gggcatatg  gggctccac  ggttgccat  tatttcatc  1800
tctaccatc  ctttgcaac  ctgatcctc  tgagtttgt  tgttgctgt  attttggac  1860
acttagaac  tgatgaaga  ctaaagaag  tcaaacaat  aaaacaaag  gaagcgaac  1920
cagatacca  agaaaaact  cctttgcgc  tgagaatct  cgaaaaatt  ccaaacaga  1980
cgcaaatgg  gaaaatctc  aaacttcct  cagatttta  agttcctaa  atcagggaa  2040
gcttcatga  gcagttcat  gaccgccag  aacaggaca  ctgctgtct  ttcagaatt  2100
tcccctcta  ctcttcctc  tcctgtgac  accccaagc  gcccacagt  gaagacaac  2160
aatacattg  tcaaaaact  cgcaagtct  ttttcagca  aagggcaag  aaccttctg  2220
aaaaggaga  cgcagtcac  aaaatctta  gagcttgca  tcgacagcg  atgctgagc  2280
gatcattcg  ggggcagcc  gcaaaggag  ggtcgatcc  cagcgtgca  catcacatc  2340
gccaggagc  caggtcact  agacatgga  ccaacagcc  gaggatcag  aggggcaaa  2400
ctcttgaaa  gttaactca  gatcattcc  atacggtgc  ctacagaaa  gcacaaaga  2460
aagacagtg  aataaagat  atccaggag  agaaggagc  agcagagat  aaaaggaag  2520
tgcaagaag  ggagctgcg  gagaaccac  catactttg  caagcctct  ttcatcgtg  2580
gtcgagaac  caggttcag  aacttctgc  gcgtggtgg  tcgagcacg  ttcaatgca  2640
ccaaaacag  ccctgtcac  ggagctgtg  aaaatacaa  gtaccacca  ctttatgat  2700
tgctgggac  tgtcaccta  ctggactgg  tcatgatca  tgtaaccat  tgctcttgc  2760
tttctatga  gttcgaatc  cccttccgg  gagtcatgc  tgcacccac  ttacagatc  2820
ctgaatatg  gtttgtgat  ttcatgagc  ttgagctta  tctgaagat  atggcagat  2880
gcttgtttt  cactccaac  gctgtcatc  gggactttg  tggcgtcat  gacatattt  2940
tctatcttg  gagcttgat  tttctttgt  ggatgcctc  aaatgtgcc  gctgagtca  3000
gagcccagc  cctgatggt  cttcggtgc  taagacctc  tcggatatt  aaactggtg  3060
cacaaatga  gaaagttgt  cgagaactt  tcagtggtt  caaggaaat  tttttggtc  3120
ccattctgt  gctgacact  atgcttgtt  ttgcaagct  tggtgttca  ctctttgcc  3180
gaaagctag  caagtgcaa  gaccccaac  ttatcagaa  ggaagactg  aacggcatc  3240
tcagaatta  tgtaagtgt  tccaagaac  taaatttaa  actaagacc  ggagagaaa  3300
aacctggat  ttgggtgcc  cgtgtttgg  caaatcctc  taactttaa  tttgacaat  3360
tgggaaatg  tatgctggc  ttgtttgaa  ttctgtcct  gaaaggctg  gtagaagtg  3420
gagatgtca  tattcatcg  gtggggccg  tccatggaa  ctatattca  gttttcgta  3480
tcctgggtt  catgattgg  ctgactctt  ttgtcggtg  agttattgc  aacttcaat  3540
aaaacaagg  gacagccct  ctgacggta  atcagagaa  atgggaaga  ctcaagagc  3600
gattgaaga  cgcacagcc  cttcatctc  cacctcggc  ggataatga  ggatttaga  3660
ctaaaatgt  tgacataac  cagcatccg  tttttaaaa  gacaattgc  ttgctggtt  3720
tggcccagt  tgtgttgct  tctgtcaag  gggatgttg  ggatcctgt  acagttcct  3780
tggcaacca  gtcggtcgt  ttcaccttc  tctttgtct  agaggttac  atgaagatc  3840
tagcaatgt  accagctgg  ttctggcaa  gcagaagaa  ccgatatga  ctcttggtg  3900
cgtctcttg  tgttgtgtg  gtggtgctc  attttgctc  gctgaatgc  tacacctac  3960
tgatgggag  ctgtgtgat  gtctttaga  ttttctcca  ctgtggaaa  catgtgaca  4020
taaagatgc  ccttttgac  gtggttgtc  gcatgtaca  gagcttctt  atcatcgta  4080
gaatgtttc  cttgctgct  tgctatgcc  ttgctgggg  ggttctgtt  ggcactgta  4140
agtatggag  gaacattaa  aggcatgcc  atttttctt  agctggcaa  gccattact  4200
tattgttcc  aattgtcac  ggggaagac  ggaataaga  tatgcatga  tgtatggtt  4260
agcctccat  ttgtactcc  gatgaattt  catattggg  aacagactg  ggcaattat  4320
caggggcac  tatgtactt  tgctcattc  atgtcatca  cgcctacat  atgctgaat  4380
tacttgtag  cataattgt  gagaatttc  ctttgtttt  ttccactga  gaggaccag  4440
ttttgagtt  caatgatct  cgccatttt  aaatcatat  gaatatggt  gatgataac  4500
agaggtgtg  tcccacctt  cgagtgaag  tcctgctac  gctactgcg  gggaggcta  4560
aagtggacc  tgataaaga  aagctcctg  ttaagcaca  gtgctatga  atggagagg  4620
tgcacaatg  tggtgatgt  accttccat  atgtcttga  catgctgtc  taccgctct  4680
tagacatca  gaagagcct  cagctagag  aactgctgg  aagggagca  ctggagtac  4740
ccatagagg  ggaggtggc  aagcagact  ttcgcatgt  gctgaagaa  tgcttaaaa  4800
gcatccggg  taaacagca  cagtcatgc  gcatcatcc  cagcctgag  gagagccag  4860
agcaagagt  gagccgatt  ctgaatcct  ccagcattg  gaccaccca  ccaagcgaa  4920
ataccaacg  caacagcca  gaccacaat  cgcaacctg  gtcaagcag  cagcagcag  4980
tcttgagcc  tactctgtc  gacagagga  gaagtcgac  ggatgcagc  gatactggg  5040
aaccccaaa  aaagattgg  caatggcgt  tgccctcag  tcccaaacc  ataagccat  5100
ctgtgtctt  ggttaacct  cggtttgga  gaaggacaa  aatgaagtc  gtggtgtgc  5160
agatgaacc  catgccaga  acagcttcc  gtggctccg  agttaaaaa  tggtggacc  5220
gacagctga  tgtggagag  gacgagagt  gagatgacc  cctagatat  tagagggga  5280
gcaaagcat  gggatttat  gggtgaaaa  cactgccta  tctcttgtt  tatctctga  5340
agagcaaac  gtagttgcc  aaccctaaa  ttcacccga  catggcatt  tcagaatta  5400
cttttgttc  tttattgga  tggtccctc  aagagtatg  agtttcaga  tactctcat  5460
tattaaaga  aatctgggg  ttgggatgt  agtcagtga  agaccactt  tccaaccta  5520
gaaaacccg  gtgtttaaa  cccagaaat  caagaaaag  aggaaaata  gtataatgc  5580
gtattgata  tattagaag  tgcatcaat  gtagatgtg  attaaatat  catgtattc  5640
gtctgtgta  gataagctg  actcacctg  actcctgta  tttgttact  ctcctctca  5700
agagtgcta  gcccatact  gcccatatt  atagtacag  agttgtagc  ctagttcac  5760
tttttttcc  atttccaat  gaaatactt  ccttgggag  aattattta  gattgatct  5820
aaaaggtca  tcatgctaa  atgacagca  cttcaaaac  acagattct  gatttttaa  5880
aacattcct  ttctcatat  atttaaaaa  tatgcctga  gttaaaaaa  ttagacaat  5940
tgatttttt  tttcaagta  tctaattga  ctgtggcct  cttccaaga  agttatata  6000
gtaggtccc  tgtaaagga  ctggctata  atataattg  tatataaca  acctgtagg  6060
atattattc  tggacttga  gagacaaaa  tattttgaa  tctttaaaa  ccctttaaa  6120
aactgagtt  ataaaaaaa  aataaaagt  ttggagtca  catagctaa  agtttacac  6180
tgagactta  tgtggactt  atggcttat  cttgctgta  ccattttgc  atgaatcag  6240
aggaacatt  tgggttggc  ttaatacac  attactatg  agattgaaa  taatttccc  6300
gcttccaga  ttatctatt  aaataataa  agaagggtg  caaaacttc  ctctaaacc  6360
cattgggaa  accacaaca  aattatatt  tcccacaca  caatgctcc  ggttctctg  6420
gaaaagtgg  aatataaaa  tattggaaa  tattgatgg  ccctggctg  gcagagtct  6480
ccctgagtt  tcattatca  ttgcatatt  gatgatcag  ttattttaa  agattgagt  6540
tgtaaaaat  ccctgatgc  taggttgct  tatgatatc  ttttgtcta  ttaaccttc  6600
tcaaatagc  aaacattgt  tccttccta  acagaagat  tgatataat  tgcccatct  6660
ctgctttta  gattacttg  gactattag  taataggca  ttcaagttc  tgccgccaa  6720
gggcctttt  attgggttt  atgtttggt  agaatttga  ttttggata  aaaagccgg  6779



<210> 1111
<211> 1737
<212> PRT
<213> Rattus norvegicus
<308> AAC68885
<400> 1111

Met Leu Lys Arg Lys Gln Ser Ser Arg Val Glu Ala Gln Pro Val Thr 
  1               5                  10                  15
Asp Phe Gly Pro Asp Glu Ser Leu Ser Asp Asn Ala Asp Ile Leu Trp 
             20                  25                  30
Ile Asn Lys Pro Trp Val His Ser Leu Leu Arg Ile Cys Ala Ile Ile 
         35                  40                  45
Ser Val Ile Ser Val Cys Met Asn Thr Pro Met Thr Phe Glu His Tyr 
     50                  55                  60
Pro Pro Leu Gln Tyr Val Thr Phe Thr Leu Asp Thr Leu Leu Met Phe 
 65                  70                  75                  80
Leu Tyr Thr Ala Glu Met Ile Ala Lys Met His Ile Arg Gly Ile Val 
                 85                  90                  95
Lys Gly Asp Ser Ser Tyr Val Lys Asp Arg Trp Cys Val Phe Asp Gly 
             100                105                110
Phe Met Val Phe Cys Leu Trp Val Ser Leu Val Leu Gln Val Phe Glu 
         115                120                125
Ile Ala Asp Ile Val Asp Gln Met Ser Pro Trp Gly Met Leu Arg Ile 
     130                135                140
Pro Arg Pro Leu Ile Met Ile Arg Ala Phe Arg Ile Tyr Phe Arg Phe 
 145                150                155                160
Glu Leu Pro Arg Thr Arg Ile Thr Asn Ile Leu Lys Arg Ser Gly Glu 
                 165                170                175
Gln Ile Trp Ser Val Ser Ile Phe Leu Leu Phe Phe Leu Leu Leu Tyr 
             180                185                190
Gly Ile Leu Gly Val Gln Met Phe Gly Thr Phe Thr Tyr His Cys Val 
         195                200                205
Val Asn Asp Thr Lys Pro Gly Asn Val Thr Trp Asn Ser Leu Ala Ile 
     210                215                220
Pro Asp Thr His Cys Ser Pro Glu Leu Glu Glu Gly Tyr Gln Cys Pro 
 225                230                235                240
Pro Gly Phe Lys Cys Met Asp Leu Glu Asp Leu Gly Leu Ser Arg Gln 
                 245                250                255
Glu Leu Gly Tyr Ser Gly Phe Asn Glu Ile Gly Thr Ser Ile Phe Thr 
             260                265                270
Val Tyr Glu Ala Ser Ser Gln Glu Gly Trp Val Phe Leu Met Tyr Arg 
         275                280                285
Ala Ile Asp Ser Phe Pro Arg Trp Arg Ser Tyr Phe Tyr Phe Ile Thr 
     290                295                300
Leu Ile Phe Phe Leu Ala Trp Leu Val Lys Asn Val Phe Ile Ala Val 
 305                310                315                320
Ile Ile Glu Thr Phe Ala Glu Ile Arg Val Gln Phe Gln Gln Met Trp 
                 325                330                335
Gly Thr Arg Ser Ser Thr Thr Ser Thr Ala Thr Thr Gln Met Phe His 
             340                345                350
Glu Asp Ala Ala Gly Gly Trp Gln Leu Val Ala Val Asp Val Asn Lys 
         355                360                365
Pro Gln Gly Arg Ala Pro Ala Cys Leu Gln Lys Met Met Arg Ser Ser 
     370                375                380
Val Phe His Met Phe Ile Leu Ser Met Val Thr Val Asp Val Ile Val 
 385                390                395                400
Ala Ala Ser Asn Tyr Tyr Lys Gly Glu Asn Phe Arg Arg Gln Tyr Asp 
                 405                410                415
Glu Phe Tyr Leu Ala Glu Val Ala Phe Thr Val Leu Phe Asp Leu Glu 
             420                425                430
Ala Leu Leu Lys Ile Trp Cys Leu Gly Phe Thr Gly Tyr Ile Ser Ser 
         435                440                445
Ser Leu His Lys Phe Glu Leu Leu Leu Val Ile Gly Thr Thr Leu His 
     450                455                460
Val Tyr Pro Asp Leu Tyr His Ser Gln Phe Thr Tyr Phe Gln Val Leu 
 465                470                475                480
Arg Val Val Arg Leu Ile Lys Ile Ser Pro Ala Leu Glu Asp Phe Val 
                 485                490                495
Tyr Lys Ile Phe Gly Pro Gly Lys Lys Leu Gly Ser Leu Val Val Phe 
             500                505                510
Thr Ala Ser Leu Leu Ile Val Met Ser Ala Ile Ser Leu Gln Met Phe 
         515                520                525
Cys Phe Val Glu Glu Leu Asp Arg Phe Thr Thr Phe Pro Arg Ala Phe 
     530                535                540
Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val Met 
 545                550                555                560
Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Leu Val Ala 
                 565                570                575
Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu Ser 
             580                585                590
Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp Leu 
         595                600                605
Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr Lys 
     610                615                620
Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn Arg 
 625                630                635                640
Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val Pro 
                 645                650                655
Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln Gln 
             660                665                670
Asp Thr Cys Cys Leu Phe Arg Ile Leu Pro Ser Thr Ser Ser Ser Ser 
         675                680                685
Cys Asp Asn Pro Lys Arg Pro Thr Val Glu Asp Asn Lys Tyr Ile Asp 
     690                695                700
Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu Leu 
 705                710                715                720
Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg Gln 
                 725                730                735
Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg Ser 
             740                745                750
Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu Arg 
         755                760                765
His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu Thr 
     770                775                780
Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln Arg 
 785                790                795                800
Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala Glu 
                 805                810                815
Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro Tyr 
             820                825                830
Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg Asn 
         835                840                845
Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr Asp 
     850                855                860
Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr Asp 
 865                870                875                880
Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Thr Val Thr 
                 885                890                895
Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg Val 
             900                905                910
Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile Phe 
         915                920                925
Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe Phe 
     930                935                940
Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile Phe 
 945                950                955                960
Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn Val 
                 965                970                975
Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu Arg 
             980                985                990
Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val Arg 
         995                1000                1005
Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu Leu 
     1010                1015                1020
Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe Ala 
 1025                1030                1035                1040
Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu Asp 
                 1045                1050                1055
Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu Asn 
             1060                1065                1070
Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro Arg 
         1075                1080                1085
Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn Ala 
     1090                1095                1100
Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu Val 
 1105                1110                1115                1120
Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr Ile 
                 1125                1130                1135
His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe Val 
             1140                1145                1150
Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu Leu 
         1155                1160                1165
Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys Ile 
     1170                1175                1180
Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe Arg 
 1185                1190                1195                1200
Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr Ile 
                 1205                1210                1215
Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp Asp 
             1220                1225                1230
Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val Phe 
         1235                1240                1245
Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met Ser 
     1250                1255                1260
Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu Val 
 1265                1270                1275                1280
Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu Asn 
                 1285                1290                1295
Ala Tyr Thr Tyr Met Met Gly Ala Cys Val Ile Val Phe Arg Phe Phe 
             1300                1305                1310
Ser Ile Cys Gly Lys His Val Thr Leu Lys Met Leu Leu Leu Thr Val 
         1315                1320                1325
Val Val Ser Met Tyr Lys Ser Phe Phe Ile Ile Val Gly Met Phe Leu 
     1330                1335                1340
Leu Leu Leu Cys Tyr Ala Phe Ala Gly Val Val Leu Phe Gly Thr Val 
 1345                1350                1355                1360
Lys Tyr Gly Glu Asn Ile Asn Arg His Ala Asn Phe Ser Ser Ala Gly 
                 1365                1370                1375
Lys Ala Ile Thr Val Leu Phe Arg Ile Val Thr Gly Glu Asp Trp Asn 
             1380                1385                1390
Lys Ile Met His Asp Cys Met Val Gln Pro Pro Phe Cys Thr Pro Asp 
         1395                1400                1405
Glu Phe Thr Tyr Trp Ala Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu 
     1410                1415                1420
Met Tyr Phe Cys Ser Phe Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn 
 1425                1430                1435                1440
Leu Leu Val Ala Ile Ile Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr 
                 1445                1450                1455
Glu Glu Asp Gln Leu Leu Ser Tyr Asn Asp Leu Arg His Phe Gln Ile 
             1460                1465                1470
Ile Trp Asn Met Val Asp Asp Asn Glu Arg Cys Asp Pro Thr Phe Arg 
         1475                1480                1485
Val Lys Phe Leu Leu Arg Leu Leu Arg Gly Arg Leu Glu Val Asp Leu 
     1490                1495                1500
Asp Lys Asp Lys Leu Leu Phe Lys His Met Cys Tyr Glu Met Glu Arg 
 1505                1510                1515                1520
Leu His Asn Gly Gly Asp Val Thr Phe His Asp Val Leu Ser Met Leu 
                 1525                1530                1535
Ser Tyr Arg Ser Val Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu Leu 
             1540                1545                1550
Leu Ala Arg Glu Gln Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala Lys 
         1555                1560                1565
Gln Thr Ile Arg Met Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg Ala 
     1570                1575                1580
Lys Gln Gln Gln Ser Cys Ser Ile Ile His Ser Leu Arg Glu Ser Gln 
 1585                1590                1595                1600
Gln Gln Glu Leu Ser Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr Thr 
                 1605                1610                1615
Gln Pro Ser Glu Asp Thr Asn Ala Asn Ser Gln Asp His Asn Thr Gln 
             1620                1625                1630
Pro Glu Ser Ser Ser Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser Asp 
         1635                1640                1645
Arg Gly Gly Ser Arg Gln Asp Ala Ala Asp Thr Gly Lys Pro Gln Arg 
     1650                1655                1660
Lys Ile Gly Gln Trp Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser His 
 1665                1670                1675                1680
Ser Val Ser Ser Val Asn Leu Arg Phe Gly Gly Arg Thr Thr Met Lys 
                 1685                1690                1695
Ser Val Val Cys Lys Met Asn Pro Met Pro Asp Thr Ala Ser Cys Gly 
             1700                1705                1710
Ser Glu Val Lys Lys Trp Trp Thr Arg Gln Leu Thr Val Glu Ser Asp 
         1715                1720                1725
Glu Ser Gly Asp Asp Leu Leu Asp Ile 
     1730                1735



<210> 1112
<211> 380
<212> DNA
<213> Homo sapiens
<308> AW295007
<400> 1112

ttttttttt  tttttatca  agagatcat  gaagcttta  tagccttta  acaccagca  60
gttgattag  gacacagta  cagggggtc  ccggttctt  tcttctttg  ctccatgtc  120
tctttctta  tgtcccaga  caaggctgt  gaaaattcc  atacattct  actccacta  180
agtgacaat  tgatcttcc  aagtagaga  aacagcgga  gctaatggg  gagctcgtc  240
gtaatggac  cttgcttaa  attttagtg  ctgcggtct  cttttccag  aggttcctt  300
ccctgatgc  gaaaacaga  ttgcgaagt  tttggtcga  gtatttgtt  tcctcaatt  360
ctgaacgtt  ggagtggtcg  380



<210> 1113
<211> 1172
<212> PRT
<213> Homo sapiens
<308> CAC40696
<400> 1113

Phe Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val 
  1               5                  10                  15
Met Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Val Val 
             20                  25                  30
Ala Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu 
         35                  40                  45
Ser Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp 
     50                  55                  60
Leu Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr 
 65                  70                  75                  80
Lys Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn 
                 85                  90                  95
Arg Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val 
             100                105                110
Pro Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln 
         115                120                125
Gln Asp Thr Cys Cys Leu Leu Arg Ser Leu Pro Thr Thr Ser Ser Ser 
     130                135                140
Ser Cys Asp His Ser Lys Arg Ser Ala Ile Glu Asp Asn Lys Tyr Ile 
 145                150                155                160
Asp Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu 
                 165                170                175
Leu Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg 
             180                185                190
Gln Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg 
         195                200                205
Ser Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu 
     210                215                220
Arg His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu 
 225                230                235                240
Thr Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln 
                 245                250                255
Arg Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala 
             260                265                270
Glu Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro 
         275                280                285
Tyr Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg 
     290                295                300
Asn Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr 
 305                310                315                320
Asp Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr 
                 325                330                335
Asp Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Ile Val 
             340                345                350
Thr Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg 
         355                360                365
Val Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile 
     370                375                380
Phe Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe 
 385                390                395                400
Phe Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile 
                 405                410                415
Phe Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn 
             420                425                430
Val Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu 
         435                440                445
Arg Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val 
     450                455                460
Arg Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu 
 465                470                475                480
Leu Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe 
                 485                490                495
Ala Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu 
             500                505                510
Asp Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu 
         515                520                525
Asn Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro 
     530                535                540
Arg Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn 
 545                550                555                560
Ala Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu 
                 565                570                575
Val Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr 
             580                585                590
Ile His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe 
         595                600                605
Val Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu 
     610                615                620
Leu Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys 
 625                630                635                640
Ile Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe 
                 645                650                655
Arg Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr 
             660                665                670
Ile Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp 
         675                680                685
Asp Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val 
     690                695                700
Phe Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met 
 705                710                715                720
Ser Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu 
                 725                730                735
Val Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu 
             740                745                750
Val Thr Leu Lys Met Leu Leu Leu Thr Val Val Val Ser Met Tyr Lys 
         755                760                765
Ser Phe Phe Ile Ile Val Gly Met Phe Leu Leu Leu Leu Cys Tyr Ala 
     770                775                780
Phe Ala Gly Val Val Leu Phe Gly Thr Val Lys Tyr Gly Glu Asn Ile 
 785                790                795                800
Asn Arg His Ala Asn Phe Ser Ser Ala Gly Lys Ala Ile Thr Val Leu 
                 805                810                815
Phe Arg Ile Val Thr Gly Glu Asp Trp Asn Lys Ile Met His Asp Cys 
             820                825                830
Met Val Gln Pro Pro Phe Cys Thr Pro Asp Glu Phe Thr Tyr Trp Ala 
         835                840                845
Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu Met Tyr Phe Cys Ser Phe 
     850                855                860
Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn Leu Leu Val Ala Ile Ile 
 865                870                875                880
Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr Glu Glu Asp Gln Leu Leu 
                 885                890                895
Ser Tyr Asn Asp Leu Arg His Phe Gln Ile Ile Trp Asn Met Val Asp 
             900                905                910
Asp Lys Arg Glu Gly Val Ile Pro Thr Phe Arg Val Lys Phe Leu Leu 
         915                920                925
Arg Leu Leu Arg Gly Arg Leu Glu Val Asp Leu Asp Lys Asp Lys Leu 
     930                935                940
Leu Phe Lys His Met Cys Tyr Glu Met Glu Arg Leu His Asn Gly Gly 
 945                950                955                960
Asp Val Thr Phe His Asp Val Leu Ser Met Leu Ser Tyr Arg Ser Val 
                 965                970                975
Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu Leu Leu Ala Arg Glu Gln 
             980                985                990
Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala Lys Gln Thr Ile Arg Met 
         995                1000                1005
Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg Ala Lys Gln Gln Gln Ser 
     1010                1015                1020
Cys Ser Ile Ile His Ser Leu Arg Glu Ser Gln Gln Gln Glu Leu Ser 
 1025                1030                1035                1040
Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr Thr Gln Pro Ser Glu Asp 
                 1045                1050                1055
Thr Asn Ala Asn Ser Gln Asp Asn Ser Met Gln Pro Glu Thr Ser Ser 
             1060                1065                1070
Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser Asp Arg Gly Gly Ser Arg 
         1075                1080                1085
Gln Asp Ala Ala Asp Ala Gly Lys Pro Gln Arg Lys Phe Gly Gln Trp 
     1090                1095                1100
Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser His Ser Val Ser Ser Val 
 1105                1110                1115                1120
Asn Leu Arg Phe Gly Gly Arg Thr Thr Met Lys Ser Val Val Cys Lys 
                 1125                1130                1135
Met Asn Pro Met Thr Asp Ala Ala Ser Cys Gly Ser Glu Val Lys Lys 
             1140                1145                1150
Trp Trp Thr Arg Gln Leu Thr Val Glu Ser Asp Glu Ser Gly Asp Asp 
         1155                1160                1165
Leu Leu Asp Ile 
     1170



<210> 1114
<211> 6779
<212> DNA
<213> Rattus norvegicus
<308> AF078779
<400> 1114

cgggcgcgc  gcggttaca  actgtggtt  tgtacctgc  tcccacagc  aacttcacc  60
tgctcaaaa  aaagcagag  tccagggtg  aagcccagc  agtaactga  tttggtcct  120
acgaatctc  gtcagacaa  gctgacata  tctggatta  taagccatg  gtgcactct  180
tgctgcgca  ctgtgccat  atcagcgtc  tctcagtgt  catgaacac  cctatgacc  240
tcgagcact  tcctcccct  cagtatgtg  ccttcaccc  ggacacttt  ctgatgttt  300
tctacactg  agagatgat  gcaaagatg  acatacggg  aattgtcaa  ggcgatagc  360
cctatgtga  ggaccgctg  tgtgttttt  atggattca  ggtcttttg  ctttgggtt  420
ctctcgtgt  acaggtgtt  gaaatagct  acatagttg  tcagatgtc  ccttggggc  480
tgctgcgga  cccacggcc  ctcattatg  tccgggctt  caggattta  ttccgattc  540
aactgccaa  gacccgaat  acaaacatt  taaagcggt  aggagaaca  atatggagt  600
tctcaatct  cctcctctt  ttccttctt  tgtatggga  tttaggagt  cagatgttt  660
gaacattta  ctaccactg  gtagtcaat  acacaaagc  agggaatgt  acctggaat  720
gcttagcta  cccagatac  cactgctcg  cagagctag  agaaggcta  cagtgcccc  780
caggattta  atgcatgga  ctggaagac  tgggactta  caggcaaga  ctgggctac  840
gtggcttta  tgagatagg  acgagtata  tcacagtct  tgaggcttc  tctcaggaa  900
gctgggtat  cctcatgta  agagcaatc  acagtttcc  ccgttggcg  tcctacttc  960
acttcatca  gctgatttt  ttccttgcc  ggcttgtca  gaatgtgtt  attgctgtc  1020
tcattgaga  atttgcaga  atcagagta  aatttcaac  aatgtgggg  actcggagc  1080
gcacaactt  cactgccac  acgcagatg  tccatgaag  tgctgccgg  ggctggcag  1140
tggtagctg  ggatgtcaa  aagccccag  gacgtgccc  agcctgcct  cagaaaatg  1200
tgcggtcat  agttttcca  atgtttatc  tgagcatgg  gactgtgga  gtaatagtt  1260
ctgccagca  ctactacaa  ggagagaac  tcagaaggc  gtatgacga  ttctacctt  1320
cagaggtgg  ttttacagt  ctttttgat  tggaagcac  tctgaagat  tggtgtttg  1380
ggtttactg  ctacatcag  tcatctctc  acaagtttg  actacttct  gttattggg  1440
caactctcc  tgtataccc  gatctttat  attctcaat  tacctactt  caggttctt  1500
gggtagtcc  gcttattaa  atttcccca  cattggaag  ttttgtgta  aagatattt  1560
gtcccggga  aaaacttgg  agcttggtg  tgttcactg  cagtctcct  atagttatg  1620
ccgccatca  tttgcagat  ttctgcttc  tcgaagaac  ggacagatt  accacattt  1680
caagggcat  tatgtccat  ttccagatc  tcacccagg  aggatgggt  gatgtgatg  1740
atcagactc  gaatgctgt  gggcatatg  gggctccac  ggttgccat  tatttcatc  1800
tctaccatc  ctttgcaac  ctgatcctc  tgagtttgt  tgttgctgt  attttggac  1860
acttagaac  tgatgaaga  ctaaagaag  tcaaacaat  aaaacaaag  gaagcgaac  1920
cagatacca  agaaaaact  cctttgcgc  tgagaatct  cgaaaaatt  ccaaacaga  1980
cgcaaatgg  gaaaatctc  aaacttcct  cagatttta  agttcctaa  atcagggaa  2040
gcttcatga  gcagttcat  gaccgccag  aacaggaca  ctgctgtct  ttcagaatt  2100
tcccctcta  ctcttcctc  tcctgtgac  accccaagc  gcccacagt  gaagacaac  2160
aatacattg  tcaaaaact  cgcaagtct  ttttcagca  aagggcaag  aaccttctg  2220
aaaaggaga  cgcagtcac  aaaatctta  gagcttgca  tcgacagcg  atgctgagc  2280
gatcattcg  ggggcagcc  gcaaaggag  ggtcgatcc  cagcgtgca  catcacatc  2340
gccaggagc  caggtcact  agacatgga  ccaacagcc  gaggatcag  aggggcaaa  2400
ctcttgaaa  gttaactca  gatcattcc  atacggtgc  ctacagaaa  gcacaaaga  2460
aagacagtg  aataaagat  atccaggag  agaaggagc  agcagagat  aaaaggaag  2520
tgcaagaag  ggagctgcg  gagaaccac  catactttg  caagcctct  ttcatcgtg  2580
gtcgagaac  caggttcag  aacttctgc  gcgtggtgg  tcgagcacg  ttcaatgca  2640
ccaaaacag  ccctgtcac  ggagctgtg  aaaatacaa  gtaccacca  ctttatgat  2700
tgctgggac  tgtcaccta  ctggactgg  tcatgatca  tgtaaccat  tgctcttgc  2760
tttctatga  gttcgaatc  cccttccgg  gagtcatgc  tgcacccac  ttacagatc  2820
ctgaatatg  gtttgtgat  ttcatgagc  ttgagctta  tctgaagat  atggcagat  2880
gcttgtttt  cactccaac  gctgtcatc  gggactttg  tggcgtcat  gacatattt  2940
tctatcttg  gagcttgat  tttctttgt  ggatgcctc  aaatgtgcc  gctgagtca  3000
gagcccagc  cctgatggt  cttcggtgc  taagacctc  tcggatatt  aaactggtg  3060
cacaaatga  gaaagttgt  cgagaactt  tcagtggtt  caaggaaat  tttttggtc  3120
ccattctgt  gctgacact  atgcttgtt  ttgcaagct  tggtgttca  ctctttgcc  3180
gaaagctag  caagtgcaa  gaccccaac  ttatcagaa  ggaagactg  aacggcatc  3240
tcagaatta  tgtaagtgt  tccaagaac  taaatttaa  actaagacc  ggagagaaa  3300
aacctggat  ttgggtgcc  cgtgtttgg  caaatcctc  taactttaa  tttgacaat  3360
tgggaaatg  tatgctggc  ttgtttgaa  ttctgtcct  gaaaggctg  gtagaagtg  3420
gagatgtca  tattcatcg  gtggggccg  tccatggaa  ctatattca  gttttcgta  3480
tcctgggtt  catgattgg  ctgactctt  ttgtcggtg  agttattgc  aacttcaat  3540
aaaacaagg  gacagccct  ctgacggta  atcagagaa  atgggaaga  ctcaagagc  3600
gattgaaga  cgcacagcc  cttcatctc  cacctcggc  ggataatga  ggatttaga  3660
ctaaaatgt  tgacataac  cagcatccg  tttttaaaa  gacaattgc  ttgctggtt  3720
tggcccagt  tgtgttgct  tctgtcaag  gggatgttg  ggatcctgt  acagttcct  3780
tggcaacca  gtcggtcgt  ttcaccttc  tctttgtct  agaggttac  atgaagatc  3840
tagcaatgt  accagctgg  ttctggcaa  gcagaagaa  ccgatatga  ctcttggtg  3900
cgtctcttg  tgttgtgtg  gtggtgctc  attttgctc  gctgaatgc  tacacctac  3960
tgatgggag  ctgtgtgat  gtctttaga  ttttctcca  ctgtggaaa  catgtgaca  4020
taaagatgc  ccttttgac  gtggttgtc  gcatgtaca  gagcttctt  atcatcgta  4080
gaatgtttc  cttgctgct  tgctatgcc  ttgctgggg  ggttctgtt  ggcactgta  4140
agtatggag  gaacattaa  aggcatgcc  atttttctt  agctggcaa  gccattact  4200
tattgttcc  aattgtcac  ggggaagac  ggaataaga  tatgcatga  tgtatggtt  4260
agcctccat  ttgtactcc  gatgaattt  catattggg  aacagactg  ggcaattat  4320
caggggcac  tatgtactt  tgctcattc  atgtcatca  cgcctacat  atgctgaat  4380
tacttgtag  cataattgt  gagaatttc  ctttgtttt  ttccactga  gaggaccag  4440
ttttgagtt  caatgatct  cgccatttt  aaatcatat  gaatatggt  gatgataac  4500
agaggtgtg  tcccacctt  cgagtgaag  tcctgctac  gctactgcg  gggaggcta  4560
aagtggacc  tgataaaga  aagctcctg  ttaagcaca  gtgctatga  atggagagg  4620
tgcacaatg  tggtgatgt  accttccat  atgtcttga  catgctgtc  taccgctct  4680
tagacatca  gaagagcct  cagctagag  aactgctgg  aagggagca  ctggagtac  4740
ccatagagg  ggaggtggc  aagcagact  ttcgcatgt  gctgaagaa  tgcttaaaa  4800
gcatccggg  taaacagca  cagtcatgc  gcatcatcc  cagcctgag  gagagccag  4860
agcaagagt  gagccgatt  ctgaatcct  ccagcattg  gaccaccca  ccaagcgaa  4920
ataccaacg  caacagcca  gaccacaat  cgcaacctg  gtcaagcag  cagcagcag  4980
tcttgagcc  tactctgtc  gacagagga  gaagtcgac  ggatgcagc  gatactggg  5040
aaccccaaa  aaagattgg  caatggcgt  tgccctcag  tcccaaacc  ataagccat  5100
ctgtgtctt  ggttaacct  cggtttgga  gaaggacaa  aatgaagtc  gtggtgtgc  5160
agatgaacc  catgccaga  acagcttcc  gtggctccg  agttaaaaa  tggtggacc  5220
gacagctga  tgtggagag  gacgagagt  gagatgacc  cctagatat  tagagggga  5280
gcaaagcat  gggatttat  gggtgaaaa  cactgccta  tctcttgtt  tatctctga  5340
agagcaaac  gtagttgcc  aaccctaaa  ttcacccga  catggcatt  tcagaatta  5400
cttttgttc  tttattgga  tggtccctc  aagagtatg  agtttcaga  tactctcat  5460
tattaaaga  aatctgggg  ttgggatgt  agtcagtga  agaccactt  tccaaccta  5520
gaaaacccg  gtgtttaaa  cccagaaat  caagaaaag  aggaaaata  gtataatgc  5580
gtattgata  tattagaag  tgcatcaat  gtagatgtg  attaaatat  catgtattc  5640
gtctgtgta  gataagctg  actcacctg  actcctgta  tttgttact  ctcctctca  5700
agagtgcta  gcccatact  gcccatatt  atagtacag  agttgtagc  ctagttcac  5760
tttttttcc  atttccaat  gaaatactt  ccttgggag  aattattta  gattgatct  5820
aaaaggtca  tcatgctaa  atgacagca  cttcaaaac  acagattct  gatttttaa  5880
aacattcct  ttctcatat  atttaaaaa  tatgcctga  gttaaaaaa  ttagacaat  5940
tgatttttt  tttcaagta  tctaattga  ctgtggcct  cttccaaga  agttatata  6000
gtaggtccc  tgtaaagga  ctggctata  atataattg  tatataaca  acctgtagg  6060
atattattc  tggacttga  gagacaaaa  tattttgaa  tctttaaaa  ccctttaaa  6120
aactgagtt  ataaaaaaa  aataaaagt  ttggagtca  catagctaa  agtttacac  6180
tgagactta  tgtggactt  atggcttat  cttgctgta  ccattttgc  atgaatcag  6240
aggaacatt  tgggttggc  ttaatacac  attactatg  agattgaaa  taatttccc  6300
gcttccaga  ttatctatt  aaataataa  agaagggtg  caaaacttc  ctctaaacc  6360
cattgggaa  accacaaca  aattatatt  tcccacaca  caatgctcc  ggttctctg  6420
gaaaagtgg  aatataaaa  tattggaaa  tattgatgg  ccctggctg  gcagagtct  6480
ccctgagtt  tcattatca  ttgcatatt  gatgatcag  ttattttaa  agattgagt  6540
tgtaaaaat  ccctgatgc  taggttgct  tatgatatc  ttttgtcta  ttaaccttc  6600
tcaaatagc  aaacattgt  tccttccta  acagaagat  tgatataat  tgcccatct  6660
ctgctttta  gattacttg  gactattag  taataggca  ttcaagttc  tgccgccaa  6720
gggcctttt  attgggttt  atgtttggt  agaatttga  ttttggata  aaaagccgg  6779



<210> 1115
<211> 1737
<212> PRT
<213> Rattus norvegicus
<308> AAC68885
<400> 1115

Met Leu Lys Arg Lys Gln Ser Ser Arg Val Glu Ala Gln Pro Val Thr 
  1               5                  10                  15
Asp Phe Gly Pro Asp Glu Ser Leu Ser Asp Asn Ala Asp Ile Leu Trp 
             20                  25                  30
Ile Asn Lys Pro Trp Val His Ser Leu Leu Arg Ile Cys Ala Ile Ile 
         35                  40                  45
Ser Val Ile Ser Val Cys Met Asn Thr Pro Met Thr Phe Glu His Tyr 
     50                  55                  60
Pro Pro Leu Gln Tyr Val Thr Phe Thr Leu Asp Thr Leu Leu Met Phe 
 65                  70                  75                  80
Leu Tyr Thr Ala Glu Met Ile Ala Lys Met His Ile Arg Gly Ile Val 
                 85                  90                  95
Lys Gly Asp Ser Ser Tyr Val Lys Asp Arg Trp Cys Val Phe Asp Gly 
             100                105                110
Phe Met Val Phe Cys Leu Trp Val Ser Leu Val Leu Gln Val Phe Glu 
         115                120                125
Ile Ala Asp Ile Val Asp Gln Met Ser Pro Trp Gly Met Leu Arg Ile 
     130                135                140
Pro Arg Pro Leu Ile Met Ile Arg Ala Phe Arg Ile Tyr Phe Arg Phe 
 145                150                155                160
Glu Leu Pro Arg Thr Arg Ile Thr Asn Ile Leu Lys Arg Ser Gly Glu 
                 165                170                175
Gln Ile Trp Ser Val Ser Ile Phe Leu Leu Phe Phe Leu Leu Leu Tyr 
             180                185                190
Gly Ile Leu Gly Val Gln Met Phe Gly Thr Phe Thr Tyr His Cys Val 
         195                200                205
Val Asn Asp Thr Lys Pro Gly Asn Val Thr Trp Asn Ser Leu Ala Ile 
     210                215                220
Pro Asp Thr His Cys Ser Pro Glu Leu Glu Glu Gly Tyr Gln Cys Pro 
 225                230                235                240
Pro Gly Phe Lys Cys Met Asp Leu Glu Asp Leu Gly Leu Ser Arg Gln 
                 245                250                255
Glu Leu Gly Tyr Ser Gly Phe Asn Glu Ile Gly Thr Ser Ile Phe Thr 
             260                265                270
Val Tyr Glu Ala Ser Ser Gln Glu Gly Trp Val Phe Leu Met Tyr Arg 
         275                280                285
Ala Ile Asp Ser Phe Pro Arg Trp Arg Ser Tyr Phe Tyr Phe Ile Thr 
     290                295                300
Leu Ile Phe Phe Leu Ala Trp Leu Val Lys Asn Val Phe Ile Ala Val 
 305                310                315                320
Ile Ile Glu Thr Phe Ala Glu Ile Arg Val Gln Phe Gln Gln Met Trp 
                 325                330                335
Gly Thr Arg Ser Ser Thr Thr Ser Thr Ala Thr Thr Gln Met Phe His 
             340                345                350
Glu Asp Ala Ala Gly Gly Trp Gln Leu Val Ala Val Asp Val Asn Lys 
         355                360                365
Pro Gln Gly Arg Ala Pro Ala Cys Leu Gln Lys Met Met Arg Ser Ser 
     370                375                380
Val Phe His Met Phe Ile Leu Ser Met Val Thr Val Asp Val Ile Val 
 385                390                395                400
Ala Ala Ser Asn Tyr Tyr Lys Gly Glu Asn Phe Arg Arg Gln Tyr Asp 
                 405                410                415
Glu Phe Tyr Leu Ala Glu Val Ala Phe Thr Val Leu Phe Asp Leu Glu 
             420                425                430
Ala Leu Leu Lys Ile Trp Cys Leu Gly Phe Thr Gly Tyr Ile Ser Ser 
         435                440                445
Ser Leu His Lys Phe Glu Leu Leu Leu Val Ile Gly Thr Thr Leu His 
     450                455                460
Val Tyr Pro Asp Leu Tyr His Ser Gln Phe Thr Tyr Phe Gln Val Leu 
 465                470                475                480
Arg Val Val Arg Leu Ile Lys Ile Ser Pro Ala Leu Glu Asp Phe Val 
                 485                490                495
Tyr Lys Ile Phe Gly Pro Gly Lys Lys Leu Gly Ser Leu Val Val Phe 
             500                505                510
Thr Ala Ser Leu Leu Ile Val Met Ser Ala Ile Ser Leu Gln Met Phe 
         515                520                525
Cys Phe Val Glu Glu Leu Asp Arg Phe Thr Thr Phe Pro Arg Ala Phe 
     530                535                540
Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val Met 
 545                550                555                560
Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Leu Val Ala 
                 565                570                575
Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu Ser 
             580                585                590
Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp Leu 
         595                600                605
Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr Lys 
     610                615                620
Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn Arg 
 625                630                635                640
Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val Pro 
                 645                650                655
Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln Gln 
             660                665                670
Asp Thr Cys Cys Leu Phe Arg Ile Leu Pro Ser Thr Ser Ser Ser Ser 
         675                680                685
Cys Asp Asn Pro Lys Arg Pro Thr Val Glu Asp Asn Lys Tyr Ile Asp 
     690                695                700
Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu Leu 
 705                710                715                720
Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg Gln 
                 725                730                735
Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg Ser 
             740                745                750
Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu Arg 
         755                760                765
His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu Thr 
     770                775                780
Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln Arg 
 785                790                795                800
Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala Glu 
                 805                810                815
Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro Tyr 
             820                825                830
Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg Asn 
         835                840                845
Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr Asp 
     850                855                860
Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr Asp 
 865                870                875                880
Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Thr Val Thr 
                 885                890                895
Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg Val 
             900                905                910
Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile Phe 
         915                920                925
Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe Phe 
     930                935                940
Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile Phe 
 945                950                955                960
Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn Val 
                 965                970                975
Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu Arg 
             980                985                990
Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val Arg 
         995                1000                1005
Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu Leu 
     1010                1015                1020
Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe Ala 
 1025                1030                1035                1040
Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu Asp 
                 1045                1050                1055
Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu Asn 
             1060                1065                1070
Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro Arg 
         1075                1080                1085
Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn Ala 
     1090                1095                1100
Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu Val 
 1105                1110                1115                1120
Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr Ile 
                 1125                1130                1135
His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe Val 
             1140                1145                1150
Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu Leu 
         1155                1160                1165
Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys Ile 
     1170                1175                1180
Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe Arg 
 1185                1190                1195                1200
Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr Ile 
                 1205                1210                1215
Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp Asp 
             1220                1225                1230
Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val Phe 
         1235                1240                1245
Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met Ser 
     1250                1255                1260
Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu Val 
 1265                1270                1275                1280
Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu Asn 
                 1285                1290                1295
Ala Tyr Thr Tyr Met Met Gly Ala Cys Val Ile Val Phe Arg Phe Phe 
             1300                1305                1310
Ser Ile Cys Gly Lys His Val Thr Leu Lys Met Leu Leu Leu Thr Val 
         1315                1320                1325
Val Val Ser Met Tyr Lys Ser Phe Phe Ile Ile Val Gly Met Phe Leu 
     1330                1335                1340
Leu Leu Leu Cys Tyr Ala Phe Ala Gly Val Val Leu Phe Gly Thr Val 
 1345                1350                1355                1360
Lys Tyr Gly Glu Asn Ile Asn Arg His Ala Asn Phe Ser Ser Ala Gly 
                 1365                1370                1375
Lys Ala Ile Thr Val Leu Phe Arg Ile Val Thr Gly Glu Asp Trp Asn 
             1380                1385                1390
Lys Ile Met His Asp Cys Met Val Gln Pro Pro Phe Cys Thr Pro Asp 
         1395                1400                1405
Glu Phe Thr Tyr Trp Ala Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu 
     1410                1415                1420
Met Tyr Phe Cys Ser Phe Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn 
 1425                1430                1435                1440
Leu Leu Val Ala Ile Ile Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr 
                 1445                1450                1455
Glu Glu Asp Gln Leu Leu Ser Tyr Asn Asp Leu Arg His Phe Gln Ile 
             1460                1465                1470
Ile Trp Asn Met Val Asp Asp Asn Glu Arg Cys Asp Pro Thr Phe Arg 
         1475                1480                1485
Val Lys Phe Leu Leu Arg Leu Leu Arg Gly Arg Leu Glu Val Asp Leu 
     1490                1495                1500
Asp Lys Asp Lys Leu Leu Phe Lys His Met Cys Tyr Glu Met Glu Arg 
 1505                1510                1515                1520
Leu His Asn Gly Gly Asp Val Thr Phe His Asp Val Leu Ser Met Leu 
                 1525                1530                1535
Ser Tyr Arg Ser Val Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu Leu 
             1540                1545                1550
Leu Ala Arg Glu Gln Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala Lys 
         1555                1560                1565
Gln Thr Ile Arg Met Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg Ala 
     1570                1575                1580
Lys Gln Gln Gln Ser Cys Ser Ile Ile His Ser Leu Arg Glu Ser Gln 
 1585                1590                1595                1600
Gln Gln Glu Leu Ser Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr Thr 
                 1605                1610                1615
Gln Pro Ser Glu Asp Thr Asn Ala Asn Ser Gln Asp His Asn Thr Gln 
             1620                1625                1630
Pro Glu Ser Ser Ser Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser Asp 
         1635                1640                1645
Arg Gly Gly Ser Arg Gln Asp Ala Ala Asp Thr Gly Lys Pro Gln Arg 
     1650                1655                1660
Lys Ile Gly Gln Trp Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser His 
 1665                1670                1675                1680
Ser Val Ser Ser Val Asn Leu Arg Phe Gly Gly Arg Thr Thr Met Lys 
                 1685                1690                1695
Ser Val Val Cys Lys Met Asn Pro Met Pro Asp Thr Ala Ser Cys Gly 
             1700                1705                1710
Ser Glu Val Lys Lys Trp Trp Thr Arg Gln Leu Thr Val Glu Ser Asp 
         1715                1720                1725
Glu Ser Gly Asp Asp Leu Leu Asp Ile 
     1730                1735



<210> 1116
<211> 380
<212> DNA
<213> Homo sapiens
<308> AW295007
<400> 1116

ttttttttt  tttttatca  agagatcat  gaagcttta  tagccttta  acaccagca  60
gttgattag  gacacagta  cagggggtc  ccggttctt  tcttctttg  ctccatgtc  120
tctttctta  tgtcccaga  caaggctgt  gaaaattcc  atacattct  actccacta  180
agtgacaat  tgatcttcc  aagtagaga  aacagcgga  gctaatggg  gagctcgtc  240
gtaatggac  cttgcttaa  attttagtg  ctgcggtct  cttttccag  aggttcctt  300
ccctgatgc  gaaaacaga  ttgcgaagt  tttggtcga  gtatttgtt  tcctcaatt  360
ctgaacgtt  ggagtggtcg  380



<210> 1117
<211> 1172
<212> PRT
<213> Homo sapiens
<308> CAC40696
<400> 1117

Phe Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val 
  1               5                  10                  15
Met Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Val Val 
             20                  25                  30
Ala Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu 
         35                  40                  45
Ser Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp 
     50                  55                  60
Leu Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr 
 65                  70                  75                  80
Lys Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn 
                 85                  90                  95
Arg Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val 
             100                105                110
Pro Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln 
         115                120                125
Gln Asp Thr Cys Cys Leu Leu Arg Ser Leu Pro Thr Thr Ser Ser Ser 
     130                135                140
Ser Cys Asp His Ser Lys Arg Ser Ala Ile Glu Asp Asn Lys Tyr Ile 
 145                150                155                160
Asp Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu 
                 165                170                175
Leu Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg 
             180                185                190
Gln Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg 
         195                200                205
Ser Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu 
     210                215                220
Arg His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu 
 225                230                235                240
Thr Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln 
                 245                250                255
Arg Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala 
             260                265                270
Glu Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro 
         275                280                285
Tyr Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg 
     290                295                300
Asn Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr 
 305                310                315                320
Asp Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr 
                 325                330                335
Asp Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Ile Val 
             340                345                350
Thr Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg 
         355                360                365
Val Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile 
     370                375                380
Phe Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe 
 385                390                395                400
Phe Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile 
                 405                410                415
Phe Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn 
             420                425                430
Val Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu 
         435                440                445
Arg Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val 
     450                455                460
Arg Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu 
 465                470                475                480
Leu Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe 
                 485                490                495
Ala Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu 
             500                505                510
Asp Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu 
         515                520                525
Asn Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro 
     530                535                540
Arg Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn 
 545                550                555                560
Ala Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu 
                 565                570                575
Val Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr 
             580                585                590
Ile His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe 
         595                600                605
Val Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu 
     610                615                620
Leu Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys 
 625                630                635                640
Ile Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe 
                 645                650                655
Arg Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr 
             660                665                670
Ile Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp 
         675                680                685
Asp Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val 
     690                695                700
Phe Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met 
 705                710                715                720
Ser Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu 
                 725                730                735
Val Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu 
             740                745                750
Val Thr Leu Lys Met Leu Leu Leu Thr Val Val Val Ser Met Tyr Lys 
         755                760                765
Ser Phe Phe Ile Ile Val Gly Met Phe Leu Leu Leu Leu Cys Tyr Ala 
     770                775                780
Phe Ala Gly Val Val Leu Phe Gly Thr Val Lys Tyr Gly Glu Asn Ile 
 785                790                795                800
Asn Arg His Ala Asn Phe Ser Ser Ala Gly Lys Ala Ile Thr Val Leu 
                 805                810                815
Phe Arg Ile Val Thr Gly Glu Asp Trp Asn Lys Ile Met His Asp Cys 
             820                825                830
Met Val Gln Pro Pro Phe Cys Thr Pro Asp Glu Phe Thr Tyr Trp Ala 
         835                840                845
Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu Met Tyr Phe Cys Ser Phe 
     850                855                860
Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn Leu Leu Val Ala Ile Ile 
 865                870                875                880
Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr Glu Glu Asp Gln Leu Leu 
                 885                890                895
Ser Tyr Asn Asp Leu Arg His Phe Gln Ile Ile Trp Asn Met Val Asp 
             900                905                910
Asp Lys Arg Glu Gly Val Ile Pro Thr Phe Arg Val Lys Phe Leu Leu 
         915                920                925
Arg Leu Leu Arg Gly Arg Leu Glu Val Asp Leu Asp Lys Asp Lys Leu 
     930                935                940
Leu Phe Lys His Met Cys Tyr Glu Met Glu Arg Leu His Asn Gly Gly 
 945                950                955                960
Asp Val Thr Phe His Asp Val Leu Ser Met Leu Ser Tyr Arg Ser Val 
                 965                970                975
Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu Leu Leu Ala Arg Glu Gln 
             980                985                990
Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala Lys Gln Thr Ile Arg Met 
         995                1000                1005
Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg Ala Lys Gln Gln Gln Ser 
     1010                1015                1020
Cys Ser Ile Ile His Ser Leu Arg Glu Ser Gln Gln Gln Glu Leu Ser 
 1025                1030                1035                1040
Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr Thr Gln Pro Ser Glu Asp 
                 1045                1050                1055
Thr Asn Ala Asn Ser Gln Asp Asn Ser Met Gln Pro Glu Thr Ser Ser 
             1060                1065                1070
Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser Asp Arg Gly Gly Ser Arg 
         1075                1080                1085
Gln Asp Ala Ala Asp Ala Gly Lys Pro Gln Arg Lys Phe Gly Gln Trp 
     1090                1095                1100
Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser His Ser Val Ser Ser Val 
 1105                1110                1115                1120
Asn Leu Arg Phe Gly Gly Arg Thr Thr Met Lys Ser Val Val Cys Lys 
                 1125                1130                1135
Met Asn Pro Met Thr Asp Ala Ala Ser Cys Gly Ser Glu Val Lys Lys 
             1140                1145                1150
Trp Trp Thr Arg Gln Leu Thr Val Glu Ser Asp Glu Ser Gly Asp Asp 
         1155                1160                1165
Leu Leu Asp Ile 
     1170



<210> 1118
<211> 6779
<212> DNA
<213> Rattus norvegicus
<308> AF078779
<400> 1118

cgggcgcgc  gcggttaca  actgtggtt  tgtacctgc  tcccacagc  aacttcacc  60
tgctcaaaa  aaagcagag  tccagggtg  aagcccagc  agtaactga  tttggtcct  120
acgaatctc  gtcagacaa  gctgacata  tctggatta  taagccatg  gtgcactct  180
tgctgcgca  ctgtgccat  atcagcgtc  tctcagtgt  catgaacac  cctatgacc  240
tcgagcact  tcctcccct  cagtatgtg  ccttcaccc  ggacacttt  ctgatgttt  300
tctacactg  agagatgat  gcaaagatg  acatacggg  aattgtcaa  ggcgatagc  360
cctatgtga  ggaccgctg  tgtgttttt  atggattca  ggtcttttg  ctttgggtt  420
ctctcgtgt  acaggtgtt  gaaatagct  acatagttg  tcagatgtc  ccttggggc  480
tgctgcgga  cccacggcc  ctcattatg  tccgggctt  caggattta  ttccgattc  540
aactgccaa  gacccgaat  acaaacatt  taaagcggt  aggagaaca  atatggagt  600
tctcaatct  cctcctctt  ttccttctt  tgtatggga  tttaggagt  cagatgttt  660
gaacattta  ctaccactg  gtagtcaat  acacaaagc  agggaatgt  acctggaat  720
gcttagcta  cccagatac  cactgctcg  cagagctag  agaaggcta  cagtgcccc  780
caggattta  atgcatgga  ctggaagac  tgggactta  caggcaaga  ctgggctac  840
gtggcttta  tgagatagg  acgagtata  tcacagtct  tgaggcttc  tctcaggaa  900
gctgggtat  cctcatgta  agagcaatc  acagtttcc  ccgttggcg  tcctacttc  960
acttcatca  gctgatttt  ttccttgcc  ggcttgtca  gaatgtgtt  attgctgtc  1020
tcattgaga  atttgcaga  atcagagta  aatttcaac  aatgtgggg  actcggagc  1080
gcacaactt  cactgccac  acgcagatg  tccatgaag  tgctgccgg  ggctggcag  1140
tggtagctg  ggatgtcaa  aagccccag  gacgtgccc  agcctgcct  cagaaaatg  1200
tgcggtcat  agttttcca  atgtttatc  tgagcatgg  gactgtgga  gtaatagtt  1260
ctgccagca  ctactacaa  ggagagaac  tcagaaggc  gtatgacga  ttctacctt  1320
cagaggtgg  ttttacagt  ctttttgat  tggaagcac  tctgaagat  tggtgtttg  1380
ggtttactg  ctacatcag  tcatctctc  acaagtttg  actacttct  gttattggg  1440
caactctcc  tgtataccc  gatctttat  attctcaat  tacctactt  caggttctt  1500
gggtagtcc  gcttattaa  atttcccca  cattggaag  ttttgtgta  aagatattt  1560
gtcccggga  aaaacttgg  agcttggtg  tgttcactg  cagtctcct  atagttatg  1620
ccgccatca  tttgcagat  ttctgcttc  tcgaagaac  ggacagatt  accacattt  1680
caagggcat  tatgtccat  ttccagatc  tcacccagg  aggatgggt  gatgtgatg  1740
atcagactc  gaatgctgt  gggcatatg  gggctccac  ggttgccat  tatttcatc  1800
tctaccatc  ctttgcaac  ctgatcctc  tgagtttgt  tgttgctgt  attttggac  1860
acttagaac  tgatgaaga  ctaaagaag  tcaaacaat  aaaacaaag  gaagcgaac  1920
cagatacca  agaaaaact  cctttgcgc  tgagaatct  cgaaaaatt  ccaaacaga  1980
cgcaaatgg  gaaaatctc  aaacttcct  cagatttta  agttcctaa  atcagggaa  2040
gcttcatga  gcagttcat  gaccgccag  aacaggaca  ctgctgtct  ttcagaatt  2100
tcccctcta  ctcttcctc  tcctgtgac  accccaagc  gcccacagt  gaagacaac  2160
aatacattg  tcaaaaact  cgcaagtct  ttttcagca  aagggcaag  aaccttctg  2220
aaaaggaga  cgcagtcac  aaaatctta  gagcttgca  tcgacagcg  atgctgagc  2280
gatcattcg  ggggcagcc  gcaaaggag  ggtcgatcc  cagcgtgca  catcacatc  2340
gccaggagc  caggtcact  agacatgga  ccaacagcc  gaggatcag  aggggcaaa  2400
ctcttgaaa  gttaactca  gatcattcc  atacggtgc  ctacagaaa  gcacaaaga  2460
aagacagtg  aataaagat  atccaggag  agaaggagc  agcagagat  aaaaggaag  2520
tgcaagaag  ggagctgcg  gagaaccac  catactttg  caagcctct  ttcatcgtg  2580
gtcgagaac  caggttcag  aacttctgc  gcgtggtgg  tcgagcacg  ttcaatgca  2640
ccaaaacag  ccctgtcac  ggagctgtg  aaaatacaa  gtaccacca  ctttatgat  2700
tgctgggac  tgtcaccta  ctggactgg  tcatgatca  tgtaaccat  tgctcttgc  2760
tttctatga  gttcgaatc  cccttccgg  gagtcatgc  tgcacccac  ttacagatc  2820
ctgaatatg  gtttgtgat  ttcatgagc  ttgagctta  tctgaagat  atggcagat  2880
gcttgtttt  cactccaac  gctgtcatc  gggactttg  tggcgtcat  gacatattt  2940
tctatcttg  gagcttgat  tttctttgt  ggatgcctc  aaatgtgcc  gctgagtca  3000
gagcccagc  cctgatggt  cttcggtgc  taagacctc  tcggatatt  aaactggtg  3060
cacaaatga  gaaagttgt  cgagaactt  tcagtggtt  caaggaaat  tttttggtc  3120
ccattctgt  gctgacact  atgcttgtt  ttgcaagct  tggtgttca  ctctttgcc  3180
gaaagctag  caagtgcaa  gaccccaac  ttatcagaa  ggaagactg  aacggcatc  3240
tcagaatta  tgtaagtgt  tccaagaac  taaatttaa  actaagacc  ggagagaaa  3300
aacctggat  ttgggtgcc  cgtgtttgg  caaatcctc  taactttaa  tttgacaat  3360
tgggaaatg  tatgctggc  ttgtttgaa  ttctgtcct  gaaaggctg  gtagaagtg  3420
gagatgtca  tattcatcg  gtggggccg  tccatggaa  ctatattca  gttttcgta  3480
tcctgggtt  catgattgg  ctgactctt  ttgtcggtg  agttattgc  aacttcaat  3540
aaaacaagg  gacagccct  ctgacggta  atcagagaa  atgggaaga  ctcaagagc  3600
gattgaaga  cgcacagcc  cttcatctc  cacctcggc  ggataatga  ggatttaga  3660
ctaaaatgt  tgacataac  cagcatccg  tttttaaaa  gacaattgc  ttgctggtt  3720
tggcccagt  tgtgttgct  tctgtcaag  gggatgttg  ggatcctgt  acagttcct  3780
tggcaacca  gtcggtcgt  ttcaccttc  tctttgtct  agaggttac  atgaagatc  3840
tagcaatgt  accagctgg  ttctggcaa  gcagaagaa  ccgatatga  ctcttggtg  3900
cgtctcttg  tgttgtgtg  gtggtgctc  attttgctc  gctgaatgc  tacacctac  3960
tgatgggag  ctgtgtgat  gtctttaga  ttttctcca  ctgtggaaa  catgtgaca  4020
taaagatgc  ccttttgac  gtggttgtc  gcatgtaca  gagcttctt  atcatcgta  4080
gaatgtttc  cttgctgct  tgctatgcc  ttgctgggg  ggttctgtt  ggcactgta  4140
agtatggag  gaacattaa  aggcatgcc  atttttctt  agctggcaa  gccattact  4200
tattgttcc  aattgtcac  ggggaagac  ggaataaga  tatgcatga  tgtatggtt  4260
agcctccat  ttgtactcc  gatgaattt  catattggg  aacagactg  ggcaattat  4320
caggggcac  tatgtactt  tgctcattc  atgtcatca  cgcctacat  atgctgaat  4380
tacttgtag  cataattgt  gagaatttc  ctttgtttt  ttccactga  gaggaccag  4440
ttttgagtt  caatgatct  cgccatttt  aaatcatat  gaatatggt  gatgataac  4500
agaggtgtg  tcccacctt  cgagtgaag  tcctgctac  gctactgcg  gggaggcta  4560
aagtggacc  tgataaaga  aagctcctg  ttaagcaca  gtgctatga  atggagagg  4620
tgcacaatg  tggtgatgt  accttccat  atgtcttga  catgctgtc  taccgctct  4680
tagacatca  gaagagcct  cagctagag  aactgctgg  aagggagca  ctggagtac  4740
ccatagagg  ggaggtggc  aagcagact  ttcgcatgt  gctgaagaa  tgcttaaaa  4800
gcatccggg  taaacagca  cagtcatgc  gcatcatcc  cagcctgag  gagagccag  4860
agcaagagt  gagccgatt  ctgaatcct  ccagcattg  gaccaccca  ccaagcgaa  4920
ataccaacg  caacagcca  gaccacaat  cgcaacctg  gtcaagcag  cagcagcag  4980
tcttgagcc  tactctgtc  gacagagga  gaagtcgac  ggatgcagc  gatactggg  5040
aaccccaaa  aaagattgg  caatggcgt  tgccctcag  tcccaaacc  ataagccat  5100
ctgtgtctt  ggttaacct  cggtttgga  gaaggacaa  aatgaagtc  gtggtgtgc  5160
agatgaacc  catgccaga  acagcttcc  gtggctccg  agttaaaaa  tggtggacc  5220
gacagctga  tgtggagag  gacgagagt  gagatgacc  cctagatat  tagagggga  5280
gcaaagcat  gggatttat  gggtgaaaa  cactgccta  tctcttgtt  tatctctga  5340
agagcaaac  gtagttgcc  aaccctaaa  ttcacccga  catggcatt  tcagaatta  5400
cttttgttc  tttattgga  tggtccctc  aagagtatg  agtttcaga  tactctcat  5460
tattaaaga  aatctgggg  ttgggatgt  agtcagtga  agaccactt  tccaaccta  5520
gaaaacccg  gtgtttaaa  cccagaaat  caagaaaag  aggaaaata  gtataatgc  5580
gtattgata  tattagaag  tgcatcaat  gtagatgtg  attaaatat  catgtattc  5640
gtctgtgta  gataagctg  actcacctg  actcctgta  tttgttact  ctcctctca  5700
agagtgcta  gcccatact  gcccatatt  atagtacag  agttgtagc  ctagttcac  5760
tttttttcc  atttccaat  gaaatactt  ccttgggag  aattattta  gattgatct  5820
aaaaggtca  tcatgctaa  atgacagca  cttcaaaac  acagattct  gatttttaa  5880
aacattcct  ttctcatat  atttaaaaa  tatgcctga  gttaaaaaa  ttagacaat  5940
tgatttttt  tttcaagta  tctaattga  ctgtggcct  cttccaaga  agttatata  6000
gtaggtccc  tgtaaagga  ctggctata  atataattg  tatataaca  acctgtagg  6060
atattattc  tggacttga  gagacaaaa  tattttgaa  tctttaaaa  ccctttaaa  6120
aactgagtt  ataaaaaaa  aataaaagt  ttggagtca  catagctaa  agtttacac  6180
tgagactta  tgtggactt  atggcttat  cttgctgta  ccattttgc  atgaatcag  6240
aggaacatt  tgggttggc  ttaatacac  attactatg  agattgaaa  taatttccc  6300
gcttccaga  ttatctatt  aaataataa  agaagggtg  caaaacttc  ctctaaacc  6360
cattgggaa  accacaaca  aattatatt  tcccacaca  caatgctcc  ggttctctg  6420
gaaaagtgg  aatataaaa  tattggaaa  tattgatgg  ccctggctg  gcagagtct  6480
ccctgagtt  tcattatca  ttgcatatt  gatgatcag  ttattttaa  agattgagt  6540
tgtaaaaat  ccctgatgc  taggttgct  tatgatatc  ttttgtcta  ttaaccttc  6600
tcaaatagc  aaacattgt  tccttccta  acagaagat  tgatataat  tgcccatct  6660
ctgctttta  gattacttg  gactattag  taataggca  ttcaagttc  tgccgccaa  6720
gggcctttt  attgggttt  atgtttggt  agaatttga  ttttggata  aaaagccgg  6779



<210> 1119
<211> 1737
<212> PRT
<213> Rattus norvegicus
<308> AAC68885
<400> 1119

Met Leu Lys Arg Lys Gln Ser Ser Arg Val Glu Ala Gln Pro Val Thr 
  1               5                  10                  15
Asp Phe Gly Pro Asp Glu Ser Leu Ser Asp Asn Ala Asp Ile Leu Trp 
             20                  25                  30
Ile Asn Lys Pro Trp Val His Ser Leu Leu Arg Ile Cys Ala Ile Ile 
         35                  40                  45
Ser Val Ile Ser Val Cys Met Asn Thr Pro Met Thr Phe Glu His Tyr 
     50                  55                  60
Pro Pro Leu Gln Tyr Val Thr Phe Thr Leu Asp Thr Leu Leu Met Phe 
 65                  70                  75                  80
Leu Tyr Thr Ala Glu Met Ile Ala Lys Met His Ile Arg Gly Ile Val 
                 85                  90                  95
Lys Gly Asp Ser Ser Tyr Val Lys Asp Arg Trp Cys Val Phe Asp Gly 
             100                105                110
Phe Met Val Phe Cys Leu Trp Val Ser Leu Val Leu Gln Val Phe Glu 
         115                120                125
Ile Ala Asp Ile Val Asp Gln Met Ser Pro Trp Gly Met Leu Arg Ile 
     130                135                140
Pro Arg Pro Leu Ile Met Ile Arg Ala Phe Arg Ile Tyr Phe Arg Phe 
 145                150                155                160
Glu Leu Pro Arg Thr Arg Ile Thr Asn Ile Leu Lys Arg Ser Gly Glu 
                 165                170                175
Gln Ile Trp Ser Val Ser Ile Phe Leu Leu Phe Phe Leu Leu Leu Tyr 
             180                185                190
Gly Ile Leu Gly Val Gln Met Phe Gly Thr Phe Thr Tyr His Cys Val 
         195                200                205
Val Asn Asp Thr Lys Pro Gly Asn Val Thr Trp Asn Ser Leu Ala Ile 
     210                215                220
Pro Asp Thr His Cys Ser Pro Glu Leu Glu Glu Gly Tyr Gln Cys Pro 
 225                230                235                240
Pro Gly Phe Lys Cys Met Asp Leu Glu Asp Leu Gly Leu Ser Arg Gln 
                 245                250                255
Glu Leu Gly Tyr Ser Gly Phe Asn Glu Ile Gly Thr Ser Ile Phe Thr 
             260                265                270
Val Tyr Glu Ala Ser Ser Gln Glu Gly Trp Val Phe Leu Met Tyr Arg 
         275                280                285
Ala Ile Asp Ser Phe Pro Arg Trp Arg Ser Tyr Phe Tyr Phe Ile Thr 
     290                295                300
Leu Ile Phe Phe Leu Ala Trp Leu Val Lys Asn Val Phe Ile Ala Val 
 305                310                315                320
Ile Ile Glu Thr Phe Ala Glu Ile Arg Val Gln Phe Gln Gln Met Trp 
                 325                330                335
Gly Thr Arg Ser Ser Thr Thr Ser Thr Ala Thr Thr Gln Met Phe His 
             340                345                350
Glu Asp Ala Ala Gly Gly Trp Gln Leu Val Ala Val Asp Val Asn Lys 
         355                360                365
Pro Gln Gly Arg Ala Pro Ala Cys Leu Gln Lys Met Met Arg Ser Ser 
     370                375                380
Val Phe His Met Phe Ile Leu Ser Met Val Thr Val Asp Val Ile Val 
 385                390                395                400
Ala Ala Ser Asn Tyr Tyr Lys Gly Glu Asn Phe Arg Arg Gln Tyr Asp 
                 405                410                415
Glu Phe Tyr Leu Ala Glu Val Ala Phe Thr Val Leu Phe Asp Leu Glu 
             420                425                430
Ala Leu Leu Lys Ile Trp Cys Leu Gly Phe Thr Gly Tyr Ile Ser Ser 
         435                440                445
Ser Leu His Lys Phe Glu Leu Leu Leu Val Ile Gly Thr Thr Leu His 
     450                455                460
Val Tyr Pro Asp Leu Tyr His Ser Gln Phe Thr Tyr Phe Gln Val Leu 
 465                470                475                480
Arg Val Val Arg Leu Ile Lys Ile Ser Pro Ala Leu Glu Asp Phe Val 
                 485                490                495
Tyr Lys Ile Phe Gly Pro Gly Lys Lys Leu Gly Ser Leu Val Val Phe 
             500                505                510
Thr Ala Ser Leu Leu Ile Val Met Ser Ala Ile Ser Leu Gln Met Phe 
         515                520                525
Cys Phe Val Glu Glu Leu Asp Arg Phe Thr Thr Phe Pro Arg Ala Phe 
     530                535                540
Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val Met 
 545                550                555                560
Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Leu Val Ala 
                 565                570                575
Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu Ser 
             580                585                590
Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp Leu 
         595                600                605
Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr Lys 
     610                615                620
Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn Arg 
 625                630                635                640
Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val Pro 
                 645                650                655
Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln Gln 
             660                665                670
Asp Thr Cys Cys Leu Phe Arg Ile Leu Pro Ser Thr Ser Ser Ser Ser 
         675                680                685
Cys Asp Asn Pro Lys Arg Pro Thr Val Glu Asp Asn Lys Tyr Ile Asp 
     690                695                700
Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu Leu 
 705                710                715                720
Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg Gln 
                 725                730                735
Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg Ser 
             740                745                750
Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu Arg 
         755                760                765
His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu Thr 
     770                775                780
Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln Arg 
 785                790                795                800
Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala Glu 
                 805                810                815
Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro Tyr 
             820                825                830
Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg Asn 
         835                840                845
Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr Asp 
     850                855                860
Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr Asp 
 865                870                875                880
Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Thr Val Thr 
                 885                890                895
Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg Val 
             900                905                910
Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile Phe 
         915                920                925
Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe Phe 
     930                935                940
Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile Phe 
 945                950                955                960
Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn Val 
                 965                970                975
Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu Arg 
             980                985                990
Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val Arg 
         995                1000                1005
Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu Leu 
     1010                1015                1020
Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe Ala 
 1025                1030                1035                1040
Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu Asp 
                 1045                1050                1055
Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu Asn 
             1060                1065                1070
Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro Arg 
         1075                1080                1085
Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn Ala 
     1090                1095                1100
Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu Val 
 1105                1110                1115                1120
Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr Ile 
                 1125                1130                1135
His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe Val 
             1140                1145                1150
Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu Leu 
         1155                1160                1165
Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys Ile 
     1170                1175                1180
Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe Arg 
 1185                1190                1195                1200
Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr Ile 
                 1205                1210                1215
Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp Asp 
             1220                1225                1230
Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val Phe 
         1235                1240                1245
Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met Ser 
     1250                1255                1260
Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu Val 
 1265                1270                1275                1280
Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu Asn 
                 1285                1290                1295
Ala Tyr Thr Tyr Met Met Gly Ala Cys Val Ile Val Phe Arg Phe Phe 
             1300                1305                1310
Ser Ile Cys Gly Lys His Val Thr Leu Lys Met Leu Leu Leu Thr Val 
         1315                1320                1325
Val Val Ser Met Tyr Lys Ser Phe Phe Ile Ile Val Gly Met Phe Leu 
     1330                1335                1340
Leu Leu Leu Cys Tyr Ala Phe Ala Gly Val Val Leu Phe Gly Thr Val 
 1345                1350                1355                1360
Lys Tyr Gly Glu Asn Ile Asn Arg His Ala Asn Phe Ser Ser Ala Gly 
                 1365                1370                1375
Lys Ala Ile Thr Val Leu Phe Arg Ile Val Thr Gly Glu Asp Trp Asn 
             1380                1385                1390
Lys Ile Met His Asp Cys Met Val Gln Pro Pro Phe Cys Thr Pro Asp 
         1395                1400                1405
Glu Phe Thr Tyr Trp Ala Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu 
     1410                1415                1420
Met Tyr Phe Cys Ser Phe Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn 
 1425                1430                1435                1440
Leu Leu Val Ala Ile Ile Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr 
                 1445                1450                1455
Glu Glu Asp Gln Leu Leu Ser Tyr Asn Asp Leu Arg His Phe Gln Ile 
             1460                1465                1470
Ile Trp Asn Met Val Asp Asp Asn Glu Arg Cys Asp Pro Thr Phe Arg 
         1475                1480                1485
Val Lys Phe Leu Leu Arg Leu Leu Arg Gly Arg Leu Glu Val Asp Leu 
     1490                1495                1500
Asp Lys Asp Lys Leu Leu Phe Lys His Met Cys Tyr Glu Met Glu Arg 
 1505                1510                1515                1520
Leu His Asn Gly Gly Asp Val Thr Phe His Asp Val Leu Ser Met Leu 
                 1525                1530                1535
Ser Tyr Arg Ser Val Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu Leu 
             1540                1545                1550
Leu Ala Arg Glu Gln Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala Lys 
         1555                1560                1565
Gln Thr Ile Arg Met Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg Ala 
     1570                1575                1580
Lys Gln Gln Gln Ser Cys Ser Ile Ile His Ser Leu Arg Glu Ser Gln 
 1585                1590                1595                1600
Gln Gln Glu Leu Ser Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr Thr 
                 1605                1610                1615
Gln Pro Ser Glu Asp Thr Asn Ala Asn Ser Gln Asp His Asn Thr Gln 
             1620                1625                1630
Pro Glu Ser Ser Ser Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser Asp 
         1635                1640                1645
Arg Gly Gly Ser Arg Gln Asp Ala Ala Asp Thr Gly Lys Pro Gln Arg 
     1650                1655                1660
Lys Ile Gly Gln Trp Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser His 
 1665                1670                1675                1680
Ser Val Ser Ser Val Asn Leu Arg Phe Gly Gly Arg Thr Thr Met Lys 
                 1685                1690                1695
Ser Val Val Cys Lys Met Asn Pro Met Pro Asp Thr Ala Ser Cys Gly 
             1700                1705                1710
Ser Glu Val Lys Lys Trp Trp Thr Arg Gln Leu Thr Val Glu Ser Asp 
         1715                1720                1725
Glu Ser Gly Asp Asp Leu Leu Asp Ile 
     1730                1735



<210> 1120
<211> 380
<212> DNA
<213> Homo sapiens
<308> AW295007
<400> 1120

ttttttttt  tttttatca  agagatcat  gaagcttta  tagccttta  acaccagca  60
gttgattag  gacacagta  cagggggtc  ccggttctt  tcttctttg  ctccatgtc  120
tctttctta  tgtcccaga  caaggctgt  gaaaattcc  atacattct  actccacta  180
agtgacaat  tgatcttcc  aagtagaga  aacagcgga  gctaatggg  gagctcgtc  240
gtaatggac  cttgcttaa  attttagtg  ctgcggtct  cttttccag  aggttcctt  300
ccctgatgc  gaaaacaga  ttgcgaagt  tttggtcga  gtatttgtt  tcctcaatt  360
ctgaacgtt  ggagtggtcg  380



<210> 1121
<211> 1172
<212> PRT
<213> Homo sapiens
<308> CAC40696
<400> 1121

Phe Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val 
  1               5                  10                  15
Met Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Val Val 
             20                  25                  30
Ala Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu 
         35                  40                  45
Ser Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp 
     50                  55                  60
Leu Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr 
 65                  70                  75                  80
Lys Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn 
                 85                  90                  95
Arg Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val 
             100                105                110
Pro Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln 
         115                120                125
Gln Asp Thr Cys Cys Leu Leu Arg Ser Leu Pro Thr Thr Ser Ser Ser 
     130                135                140
Ser Cys Asp His Ser Lys Arg Ser Ala Ile Glu Asp Asn Lys Tyr Ile 
 145                150                155                160
Asp Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu 
                 165                170                175
Leu Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg 
             180                185                190
Gln Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg 
         195                200                205
Ser Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu 
     210                215                220
Arg His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu 
 225                230                235                240
Thr Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln 
                 245                250                255
Arg Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala 
             260                265                270
Glu Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro 
         275                280                285
Tyr Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg 
     290                295                300
Asn Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr 
 305                310                315                320
Asp Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr 
                 325                330                335
Asp Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Ile Val 
             340                345                350
Thr Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg 
         355                360                365
Val Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile 
     370                375                380
Phe Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe 
 385                390                395                400
Phe Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile 
                 405                410                415
Phe Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn 
             420                425                430
Val Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu 
         435                440                445
Arg Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val 
     450                455                460
Arg Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu 
 465                470                475                480
Leu Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe 
                 485                490                495
Ala Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu 
             500                505                510
Asp Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu 
         515                520                525
Asn Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro 
     530                535                540
Arg Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn 
 545                550                555                560
Ala Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu 
                 565                570                575
Val Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr 
             580                585                590
Ile His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe 
         595                600                605
Val Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu 
     610                615                620
Leu Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys 
 625                630                635                640
Ile Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe 
                 645                650                655
Arg Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr 
             660                665                670
Ile Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp 
         675                680                685
Asp Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val 
     690                695                700
Phe Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met 
 705                710                715                720
Ser Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu 
                 725                730                735
Val Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu 
             740                745                750
Val Thr Leu Lys Met Leu Leu Leu Thr Val Val Val Ser Met Tyr Lys 
         755                760                765
Ser Phe Phe Ile Ile Val Gly Met Phe Leu Leu Leu Leu Cys Tyr Ala 
     770                775                780
Phe Ala Gly Val Val Leu Phe Gly Thr Val Lys Tyr Gly Glu Asn Ile 
 785                790                795                800
Asn Arg His Ala Asn Phe Ser Ser Ala Gly Lys Ala Ile Thr Val Leu 
                 805                810                815
Phe Arg Ile Val Thr Gly Glu Asp Trp Asn Lys Ile Met His Asp Cys 
             820                825                830
Met Val Gln Pro Pro Phe Cys Thr Pro Asp Glu Phe Thr Tyr Trp Ala 
         835                840                845
Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu Met Tyr Phe Cys Ser Phe 
     850                855                860
Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn Leu Leu Val Ala Ile Ile 
 865                870                875                880
Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr Glu Glu Asp Gln Leu Leu 
                 885                890                895
Ser Tyr Asn Asp Leu Arg His Phe Gln Ile Ile Trp Asn Met Val Asp 
             900                905                910
Asp Lys Arg Glu Gly Val Ile Pro Thr Phe Arg Val Lys Phe Leu Leu 
         915                920                925
Arg Leu Leu Arg Gly Arg Leu Glu Val Asp Leu Asp Lys Asp Lys Leu 
     930                935                940
Leu Phe Lys His Met Cys Tyr Glu Met Glu Arg Leu His Asn Gly Gly 
 945                950                955                960
Asp Val Thr Phe His Asp Val Leu Ser Met Leu Ser Tyr Arg Ser Val 
                 965                970                975
Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu Leu Leu Ala Arg Glu Gln 
             980                985                990
Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala Lys Gln Thr Ile Arg Met 
         995                1000                1005
Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg Ala Lys Gln Gln Gln Ser 
     1010                1015                1020
Cys Ser Ile Ile His Ser Leu Arg Glu Ser Gln Gln Gln Glu Leu Ser 
 1025                1030                1035                1040
Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr Thr Gln Pro Ser Glu Asp 
                 1045                1050                1055
Thr Asn Ala Asn Ser Gln Asp Asn Ser Met Gln Pro Glu Thr Ser Ser 
             1060                1065                1070
Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser Asp Arg Gly Gly Ser Arg 
         1075                1080                1085
Gln Asp Ala Ala Asp Ala Gly Lys Pro Gln Arg Lys Phe Gly Gln Trp 
     1090                1095                1100
Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser His Ser Val Ser Ser Val 
 1105                1110                1115                1120
Asn Leu Arg Phe Gly Gly Arg Thr Thr Met Lys Ser Val Val Cys Lys 
                 1125                1130                1135
Met Asn Pro Met Thr Asp Ala Ala Ser Cys Gly Ser Glu Val Lys Lys 
             1140                1145                1150
Trp Trp Thr Arg Gln Leu Thr Val Glu Ser Asp Glu Ser Gly Asp Asp 
         1155                1160                1165
Leu Leu Asp Ile 
     1170



<210> 1122
<211> 519
<212> DNA
<213> Rattus norvegicus
<308> AF079873
<400> 1122

ctcattacg  agatggttg  tctcaaccc  gactttaaa  cacctgcag  ttacaagcc  60
ccagcaaca  gtgtgagcg  taaagtaat  atcccccaa  acgagtatc  agaaatcaa  120
tttgtgggt  tcctaattg  gcccagagg  aacaccctg  agaacattg  gaaggaatg  180
aacgccaag  tcatgatac  gggaaaggg  tcagtaaaa  aagggaaag  tgggcgtaa  240
gatggtcag  tgttgccag  agaagatga  cctcttcat  ctctagtca  tgccaatac  300
atggagaat  tcaaaaagg  agtggaaca  atcagaaac  tcctgaagc  gggtattga  360
accccagag  accagaatg  cctaaggaa  atgcagctt  gagagttag  tcgcttgaa  420
ggcactcta  gggaagatg  taacaggat  ttgagaccc  ggcagagct  agagacacg  480
agcattacc  acacgactg  gtgtactaa  tgtggaggg  519



<210> 1123
<211> 173
<212> PRT
<213> Rattus norvegicus
<308> AAC29484
<400> 1123

Leu Ile Thr Glu Met Val Ala Leu Asn Pro Asp Phe Lys Pro Pro Ala 
  1               5                  10                  15
Asp Tyr Lys Pro Pro Ala Thr Arg Val Ser Asp Lys Val Met Ile Pro 
             20                  25                  30
Gln Asp Glu Tyr Pro Glu Ile Asn Phe Val Gly Leu Leu Ile Gly Pro 
         35                  40                  45
Arg Gly Asn Thr Leu Lys Asn Ile Glu Lys Glu Cys Asn Ala Lys Ile 
     50                  55                  60
Met Ile Arg Gly Lys Gly Ser Val Lys Glu Gly Lys Val Gly Arg Lys 
 65                  70                  75                  80
Asp Gly Gln Met Leu Pro Gly Glu Asp Glu Pro Leu His Ala Leu Val 
                 85                  90                  95
Thr Ala Asn Thr Met Glu Asn Val Lys Lys Ala Val Glu Gln Ile Arg 
             100                105                110
Asn Ile Leu Lys Gln Gly Ile Glu Thr Pro Glu Asp Gln Asn Asp Leu 
         115                120                125
Arg Lys Met Gln Leu Arg Glu Leu Ala Arg Leu Asn Gly Thr Leu Arg 
     130                135                140
Glu Asp Asp Asn Arg Ile Leu Arg Pro Trp Gln Ser Ser Glu Thr Arg 
 145                150                155                160
Ser Ile Thr Asn Thr Thr Val Cys Thr Lys Cys Gly Gly 
                 165                170



<210> 1124
<211> 1930
<212> DNA
<213> Rattus norvegicus
<308> AF080468
<400> 1124

aaaaacaca  ctcagcaga  ccgggcact  gagagggag  tgcaagcag  agcagtcaa  60
agtgtggtc  gaagcaccg  gagtggacc  gcagggccg  ctttttcta  catggcggc  120
caaggctat  gctattacc  cactgtcat  ttcacagcc  tgttcggag  ctacagcct  180
tactacttc  accgcaaaa  cttctcttt  gtcatgccc  ccttggtgg  tgagatcgc  240
ctggacaag  acgatttgg  gctcatcac  agcagccag  cggcagcct  cgccatcag  300
aagtttgtg  gcggggtgc  gtctgatca  atgagtgcc  gttggctct  ctcctctgg  360
ctgctcctg  ttggtctgg  caacgtagt  ttctcgtgg  gctctacag  accggcttt  420
gctgctctc  ggtttctta  tggtctggc  caggggcta  gctggcccc  ctgtgggaa  480
atcctgagg  agtggtttg  gccatccca  tttggtact  ggtgggctg  gttgtcaac  540
agcatgaac  tggctggaa  cctgggacc  atcttggcg  caatccttg  tcagagcta  600
agctggcgc  gcaccctgg  cctgtctgg  tcactgtgt  tggttgtct  cttcttctg  660
ctcctgctc  tccacaacg  acctgctga  gttggactc  gaaatctgg  ccctcgccc  720
tccaagggc  aaaagggct  gtcaaagga  gagagcacc  tacaggacc  gctgctgtc  780
ccctatctc  gggtgctct  cactggcta  ctcgtggtc  ttggggtaa  gacttgctg  840
acagactgg  gccagttct  ccttatcca  gagagaggg  agtcggccc  tgtgggtag  900
tcctacatc  gtgccctag  ggttggagg  cttgtaggc  gcattgcag  tggctatct  960
tcagacagg  ctatggcaa  ggcagggct  tctgtgtat  ggaaccctc  ccacagcct  1020
ttgctgctc  tgatggctg  catggcagc  tccatgttc  tcttccggg  aacagtgac  1080
agcgactct  ccaagatct  gatcctggt  ttgggagct  tatttggtt  ctcttctta  1140
ggtcccatt  ccttgtttg  agtcatagc  aatgagagt  cacctccca  cttgtgtgg  1200
acctctcat  ctattgtgg  gctcatggc  aatgtgggt  gatttctgg  tgggttacc  1260
ttcagtacc  tcgccaagc  ctatagctg  agcacagcc  tctgggtgg  agaagtgat  1320
tgtatagcc  gcacagttg  cttcttctt  cttcgaaat  tccgcacca  gatgggccg  1380
gtatccaag  aggcagagt  aaaagagca  tcactatag  gcatcccca  ctgcaacct  1440
attggcagg  cacagaaag  aagagaggc  gctctggct  gaacagagc  tttacatat  1500
tgtgtctac  ctgtctctc  ggacctccg  ggtgctgca  gttaccagt  gctaatgag  1560
tcctatgct  tatttaaat  atgtttggt  ttaggctcc  ttggcttct  tttctacct  1620
ctagcagac  gacaactcc  aaattcagg  tgtctccta  acccctctt  ctctcctga  1680
tccccatct  ctagtgagg  ggttctatc  ctgcagctg  agaatatta  tggcctgtg  1740
tttctgctg  accccaagg  ttcttgtta  gggtcaaca  tgttgccaa  acctcagtc  1800
ctaagggag  agaggaggc  accactctc  tcagttacc  ggggacaaa  gggaggaat  1860
tagagagca  actgtcttg  atagactaa  aaaactaga  ttgatacta  aaaaaaaaa  1920
aaaaaaaaaa  1930



<210> 1125
<211> 429
<212> PRT
<213> Rattus norvegicus
<308> AAC79839
<400> 1125

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Thr Ala 
  1               5                  10                  15
Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
             20                  25                  30
Phe Val Met Pro Ser Leu Val Asp Glu Ile Ala Leu Asp Lys Asp Asp 
         35                  40                  45
Leu Gly Leu Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
     50                  55                  60
Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
 65                  70                  75                  80
Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Val Val Phe Ser Trp 
                 85                  90                  95
Ser Ser Thr Val Pro Ala Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
             100                105                110
Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Ile Leu Arg Lys Trp 
         115                120                125
Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Val Leu Ser Thr Ser 
     130                135                140
Met Asn Leu Ala Gly Ser Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
 145                150                155                160
Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ser Leu Cys 
                 165                170                175
Val Val Val Ser Phe Phe Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
             180                185                190
Asp Val Gly Leu Arg Asn Leu Asp Pro Arg Pro Ser Lys Gly Lys Lys 
         195                200                205
Gly Ser Ser Lys Glu Glu Ser Thr Leu Gln Asp Leu Leu Leu Ser Pro 
     210                215                220
Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
 225                230                235                240
Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Arg Gly 
                 245                250                255
Gln Ser Ala Leu Val Gly Ser Ser Tyr Ile Ser Ala Leu Glu Val Gly 
             260                265                270
Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
         275                280                285
Ala Lys Ala Gly Leu Ser Val Tyr Gly Asn Pro Arg His Ser Leu Leu 
     290                295                300
Leu Leu Met Met Ala Gly Met Ala Ala Ser Met Phe Leu Phe Arg Val 
 305                310                315                320
Thr Val Thr Ser Asp Ser Pro Lys Ile Trp Ile Leu Val Leu Gly Ala 
                 325                330                335
Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
             340                345                350
Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
         355                360                365
Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
     370                375                380
Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
 385                390                395                400
Glu Val Ile Cys Ile Ala Ser Thr Val Val Phe Phe Leu Leu Arg Asn 
                 405                410                415
Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
             420                425



<210> 1126
<211> 2560
<212> DNA
<213> Homo sapiens
<308> NM_001467
<400> 1126

ggcacgagg  gccaccgag  cgctgtccc  gaccaccag  acgagaccc  tttctatcg  60
gccagtcct  tggtctccg  acctctcca  ctcctgcac  cccggcccc  gtggttccc  120
gccgcacag  agcgtgtcc  gggtagcgt  aggacccac  gggctgagc  ggtgccacg  180
gcccgccgc  tcttcgccg  ccgccgcct  tcctcctct  ccgcccgcc  cctggccct  240
ccctaccag  ctgagcctc  ggctgccag  agcgcgggg  ctccgggag  atacgtgcg  300
tcgcccgct  cgcgtgcgc  tacgccttc  gctccagtt  ctttcccaa  tgagcggaa  360
agccggggc  tgttgccgg  gccctgggc  ggacggttg  gccctgcag  ccgaagccc  420
ccggggcac  ttcccgccc  cgagctgcc  agtccctct  cttgcggcc  ctgccaacg  480
cccacagga  actgggtcc  cttggagcc  ccccaggct  aatgattgt  cagaaggcg  540
ctataaagg  agcctggga  gctgggtgg  ggagggagc  gaaaaaacc  aactcagca  600
atctgggaa  tgtgagagc  gcaagcagg  actgtggtc  gaggctgtg  gtcttggct  660
gtagggcct  ctcttttct  ccatggcag  ccagggcta  ggctattat  gcactgtga  720
cttctcagc  atgtttggg  gctacagcc  gtattactt  aatcgcaag  ccttctcct  780
tgtcatgcc  tcattggtg  aagagatcc  tttggacaa  gatgatttg  ggttcatca  840
cagcagcca  tcggcagct  atgctatca  caagtttgt  agtggggtg  tgtctgacc  900
gatgagtgc  cgctggctc  tctcttctg  gctgctcct  gttggcctg  tcaacatat  960
ctttgcctg  agctccaca  tacctgtct  tgctgccct  tggttcctt  atggcctgg  1020
ccaggggct  ggctggccc  catgtggga  ggtcctgcg  aagtggttt  agccatctc  1080
gtttggcac  tggtgggcc  tcctgtcaa  cagcatgaa  ctggctgga  ggctgggcc  1140
tatcctggc  accatcctt  cccagagct  cagctggcg  agcacgctg  ccctatctg  1200
ggcactgtg  gtggttgtc  ccttcctct  tctcctgct  atccacaat  aacctgctg  1260
tgttggact  cgcaacctg  accccatgc  ctctgaggg  aagaagggc  ccttgaagg  1320
ggagagcac  ctgcaggag  tgctgctgt  cccttacct  tgggtgctc  ccactggtt  1380
ccttgtggt  tttggagta  agacctgct  tactgactg  ggccagttc  tccttatcc  1440
ggagaaagg  cagtcagcc  ttgtaggta  ctcctacat  agtgccctg  aagttgggg  1500
ccttgtagg  agcatcgca  ctggctacc  gtcagaccg  gccatggca  aggcgggac  1560
gtccaacta  gggaaccct  gccatggcc  gttgctgtt  atgatggct  gcatgacag  1620
gtccatgta  ctcttccgg  taacagtga  cagtgactc  cccaagctc  ggatcctgg  1680
attgggagc  gtatttggt  tctcctcgt  tggccccat  gccctgttt  gagtcatag  1740
caacgagag  gcccctccc  acttgtgtg  cacctccca  gccattgtg  gactcatgg  1800
caatgtggg  ggctttctg  ctgggctgc  cttcagcac  attgccaag  actacagtt  1860
gagcacagc  ttctgggtg  ctgaagtga  ttgtgcggc  agcacggct  ccttcttcc  1920
cctacgaaa  atccgcacc  agatgggcc  agtgtccaa  aaggctgag  gaagagagt  1980
caggttccg  agcaccatc  cacggtggc  ttccccctg  acgctctgc  gggagaaaa  2040
gaggggcct  cctggctag  cctgaacct  tcactttcc  tttctgcgc  ttttctgtc  2100
cccgggtgg  gctggaagt  atcagtggc  agtgaggtc  cagctccct  atcctatgc  2160
ctatttaaa  gataacctt  ggccttaga  tccgttagc  cctatttcc  gccttcaga  2220
aaacaggaa  cttctgcag  caggaaggc  cctgtaccc  tcttctttt  ctaggccct  2280
tcctgcccg  atcctaccc  atccccacc  gaagtgagg  tatccctgc  gctgcaggg  2340
actaatgac  cttgacttc  gctgggtcc  aagtcctct  agcagtggg  gactgctgt  2400
gccaatacc  cagactcca  ggaaagaga  gaggccatc  ttctcactg  accactagg  2460
gcagttgga  ataggtggg  agaaaaggt  acttgttat  gaagattaa  actagattt  2520
atactgaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  2560



<210> 1127
<211> 429
<212> PRT
<213> Homo sapiens
<308> O43826
<400> 1127

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Ser Ala 
  1               5                  10                  15
Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
             20                  25                  30
Phe Val Met Pro Ser Leu Val Glu Glu Ile Pro Leu Asp Lys Asp Asp 
         35                  40                  45
Leu Gly Phe Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
     50                  55                  60
Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
 65                  70                  75                  80
Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Ile Phe Phe Ala Trp 
                 85                  90                  95
Ser Ser Thr Val Pro Val Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
             100                105                110
Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Val Leu Arg Lys Trp 
         115                120                125
Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Ile Leu Ser Thr Ser 
     130                135                140
Met Asn Leu Ala Gly Gly Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
 145                150                155                160
Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ala Leu Cys 
                 165                170                175
Val Val Val Ser Phe Leu Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
             180                185                190
Asp Val Gly Leu Arg Asn Leu Asp Pro Met Pro Ser Glu Gly Lys Lys 
         195                200                205
Gly Ser Leu Lys Glu Glu Ser Thr Leu Gln Glu Leu Leu Leu Ser Pro 
     210                215                220
Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
 225                230                235                240
Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Lys Gly 
                 245                250                255
Gln Ser Ala Leu Val Gly Ser Ser Tyr Met Ser Ala Leu Glu Val Gly 
             260                265                270
Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
         275                280                285
Ala Lys Ala Gly Leu Ser Asn Tyr Gly Asn Pro Arg His Gly Leu Leu 
     290                295                300
Leu Phe Met Met Ala Gly Met Thr Val Ser Met Tyr Leu Phe Arg Val 
 305                310                315                320
Thr Val Thr Ser Asp Ser Pro Lys Leu Trp Ile Leu Val Leu Gly Ala 
                 325                330                335
Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
             340                345                350
Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
         355                360                365
Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
     370                375                380
Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
 385                390                395                400
Glu Val Ile Cys Ala Ala Ser Thr Ala Ala Phe Phe Leu Leu Arg Asn 
                 405                410                415
Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
             420                425



<210> 1128
<211> 1930
<212> DNA
<213> Rattus norvegicus
<308> AF080468
<400> 1128

aaaaacaca  ctcagcaga  ccgggcact  gagagggag  tgcaagcag  agcagtcaa  60
agtgtggtc  gaagcaccg  gagtggacc  gcagggccg  ctttttcta  catggcggc  120
caaggctat  gctattacc  cactgtcat  ttcacagcc  tgttcggag  ctacagcct  180
tactacttc  accgcaaaa  cttctcttt  gtcatgccc  ccttggtgg  tgagatcgc  240
ctggacaag  acgatttgg  gctcatcac  agcagccag  cggcagcct  cgccatcag  300
aagtttgtg  gcggggtgc  gtctgatca  atgagtgcc  gttggctct  ctcctctgg  360
ctgctcctg  ttggtctgg  caacgtagt  ttctcgtgg  gctctacag  accggcttt  420
gctgctctc  ggtttctta  tggtctggc  caggggcta  gctggcccc  ctgtgggaa  480
atcctgagg  agtggtttg  gccatccca  tttggtact  ggtgggctg  gttgtcaac  540
agcatgaac  tggctggaa  cctgggacc  atcttggcg  caatccttg  tcagagcta  600
agctggcgc  gcaccctgg  cctgtctgg  tcactgtgt  tggttgtct  cttcttctg  660
ctcctgctc  tccacaacg  acctgctga  gttggactc  gaaatctgg  ccctcgccc  720
tccaagggc  aaaagggct  gtcaaagga  gagagcacc  tacaggacc  gctgctgtc  780
ccctatctc  gggtgctct  cactggcta  ctcgtggtc  ttggggtaa  gacttgctg  840
acagactgg  gccagttct  ccttatcca  gagagaggg  agtcggccc  tgtgggtag  900
tcctacatc  gtgccctag  ggttggagg  cttgtaggc  gcattgcag  tggctatct  960
tcagacagg  ctatggcaa  ggcagggct  tctgtgtat  ggaaccctc  ccacagcct  1020
ttgctgctc  tgatggctg  catggcagc  tccatgttc  tcttccggg  aacagtgac  1080
agcgactct  ccaagatct  gatcctggt  ttgggagct  tatttggtt  ctcttctta  1140
ggtcccatt  ccttgtttg  agtcatagc  aatgagagt  cacctccca  cttgtgtgg  1200
acctctcat  ctattgtgg  gctcatggc  aatgtgggt  gatttctgg  tgggttacc  1260
ttcagtacc  tcgccaagc  ctatagctg  agcacagcc  tctgggtgg  agaagtgat  1320
tgtatagcc  gcacagttg  cttcttctt  cttcgaaat  tccgcacca  gatgggccg  1380
gtatccaag  aggcagagt  aaaagagca  tcactatag  gcatcccca  ctgcaacct  1440
attggcagg  cacagaaag  aagagaggc  gctctggct  gaacagagc  tttacatat  1500
tgtgtctac  ctgtctctc  ggacctccg  ggtgctgca  gttaccagt  gctaatgag  1560
tcctatgct  tatttaaat  atgtttggt  ttaggctcc  ttggcttct  tttctacct  1620
ctagcagac  gacaactcc  aaattcagg  tgtctccta  acccctctt  ctctcctga  1680
tccccatct  ctagtgagg  ggttctatc  ctgcagctg  agaatatta  tggcctgtg  1740
tttctgctg  accccaagg  ttcttgtta  gggtcaaca  tgttgccaa  acctcagtc  1800
ctaagggag  agaggaggc  accactctc  tcagttacc  ggggacaaa  gggaggaat  1860
tagagagca  actgtcttg  atagactaa  aaaactaga  ttgatacta  aaaaaaaaa  1920
aaaaaaaaaa  1930



<210> 1129
<211> 429
<212> PRT
<213> Rattus norvegicus
<308> AAC79839
<400> 1129

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Thr Ala 
  1               5                  10                  15
Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
             20                  25                  30
Phe Val Met Pro Ser Leu Val Asp Glu Ile Ala Leu Asp Lys Asp Asp 
         35                  40                  45
Leu Gly Leu Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
     50                  55                  60
Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
 65                  70                  75                  80
Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Val Val Phe Ser Trp 
                 85                  90                  95
Ser Ser Thr Val Pro Ala Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
             100                105                110
Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Ile Leu Arg Lys Trp 
         115                120                125
Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Val Leu Ser Thr Ser 
     130                135                140
Met Asn Leu Ala Gly Ser Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
 145                150                155                160
Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ser Leu Cys 
                 165                170                175
Val Val Val Ser Phe Phe Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
             180                185                190
Asp Val Gly Leu Arg Asn Leu Asp Pro Arg Pro Ser Lys Gly Lys Lys 
         195                200                205
Gly Ser Ser Lys Glu Glu Ser Thr Leu Gln Asp Leu Leu Leu Ser Pro 
     210                215                220
Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
 225                230                235                240
Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Arg Gly 
                 245                250                255
Gln Ser Ala Leu Val Gly Ser Ser Tyr Ile Ser Ala Leu Glu Val Gly 
             260                265                270
Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
         275                280                285
Ala Lys Ala Gly Leu Ser Val Tyr Gly Asn Pro Arg His Ser Leu Leu 
     290                295                300
Leu Leu Met Met Ala Gly Met Ala Ala Ser Met Phe Leu Phe Arg Val 
 305                310                315                320
Thr Val Thr Ser Asp Ser Pro Lys Ile Trp Ile Leu Val Leu Gly Ala 
                 325                330                335
Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
             340                345                350
Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
         355                360                365
Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
     370                375                380
Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
 385                390                395                400
Glu Val Ile Cys Ile Ala Ser Thr Val Val Phe Phe Leu Leu Arg Asn 
                 405                410                415
Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
             420                425



<210> 1130
<211> 2560
<212> DNA
<213> Homo sapiens
<308> NM_001467
<400> 1130

ggcacgagg  gccaccgag  cgctgtccc  gaccaccag  acgagaccc  tttctatcg  60
gccagtcct  tggtctccg  acctctcca  ctcctgcac  cccggcccc  gtggttccc  120
gccgcacag  agcgtgtcc  gggtagcgt  aggacccac  gggctgagc  ggtgccacg  180
gcccgccgc  tcttcgccg  ccgccgcct  tcctcctct  ccgcccgcc  cctggccct  240
ccctaccag  ctgagcctc  ggctgccag  agcgcgggg  ctccgggag  atacgtgcg  300
tcgcccgct  cgcgtgcgc  tacgccttc  gctccagtt  ctttcccaa  tgagcggaa  360
agccggggc  tgttgccgg  gccctgggc  ggacggttg  gccctgcag  ccgaagccc  420
ccggggcac  ttcccgccc  cgagctgcc  agtccctct  cttgcggcc  ctgccaacg  480
cccacagga  actgggtcc  cttggagcc  ccccaggct  aatgattgt  cagaaggcg  540
ctataaagg  agcctggga  gctgggtgg  ggagggagc  gaaaaaacc  aactcagca  600
atctgggaa  tgtgagagc  gcaagcagg  actgtggtc  gaggctgtg  gtcttggct  660
gtagggcct  ctcttttct  ccatggcag  ccagggcta  ggctattat  gcactgtga  720
cttctcagc  atgtttggg  gctacagcc  gtattactt  aatcgcaag  ccttctcct  780
tgtcatgcc  tcattggtg  aagagatcc  tttggacaa  gatgatttg  ggttcatca  840
cagcagcca  tcggcagct  atgctatca  caagtttgt  agtggggtg  tgtctgacc  900
gatgagtgc  cgctggctc  tctcttctg  gctgctcct  gttggcctg  tcaacatat  960
ctttgcctg  agctccaca  tacctgtct  tgctgccct  tggttcctt  atggcctgg  1020
ccaggggct  ggctggccc  catgtggga  ggtcctgcg  aagtggttt  agccatctc  1080
gtttggcac  tggtgggcc  tcctgtcaa  cagcatgaa  ctggctgga  ggctgggcc  1140
tatcctggc  accatcctt  cccagagct  cagctggcg  agcacgctg  ccctatctg  1200
ggcactgtg  gtggttgtc  ccttcctct  tctcctgct  atccacaat  aacctgctg  1260
tgttggact  cgcaacctg  accccatgc  ctctgaggg  aagaagggc  ccttgaagg  1320
ggagagcac  ctgcaggag  tgctgctgt  cccttacct  tgggtgctc  ccactggtt  1380
ccttgtggt  tttggagta  agacctgct  tactgactg  ggccagttc  tccttatcc  1440
ggagaaagg  cagtcagcc  ttgtaggta  ctcctacat  agtgccctg  aagttgggg  1500
ccttgtagg  agcatcgca  ctggctacc  gtcagaccg  gccatggca  aggcgggac  1560
gtccaacta  gggaaccct  gccatggcc  gttgctgtt  atgatggct  gcatgacag  1620
gtccatgta  ctcttccgg  taacagtga  cagtgactc  cccaagctc  ggatcctgg  1680
attgggagc  gtatttggt  tctcctcgt  tggccccat  gccctgttt  gagtcatag  1740
caacgagag  gcccctccc  acttgtgtg  cacctccca  gccattgtg  gactcatgg  1800
caatgtggg  ggctttctg  ctgggctgc  cttcagcac  attgccaag  actacagtt  1860
gagcacagc  ttctgggtg  ctgaagtga  ttgtgcggc  agcacggct  ccttcttcc  1920
cctacgaaa  atccgcacc  agatgggcc  agtgtccaa  aaggctgag  gaagagagt  1980
caggttccg  agcaccatc  cacggtggc  ttccccctg  acgctctgc  gggagaaaa  2040
gaggggcct  cctggctag  cctgaacct  tcactttcc  tttctgcgc  ttttctgtc  2100
cccgggtgg  gctggaagt  atcagtggc  agtgaggtc  cagctccct  atcctatgc  2160
ctatttaaa  gataacctt  ggccttaga  tccgttagc  cctatttcc  gccttcaga  2220
aaacaggaa  cttctgcag  caggaaggc  cctgtaccc  tcttctttt  ctaggccct  2280
tcctgcccg  atcctaccc  atccccacc  gaagtgagg  tatccctgc  gctgcaggg  2340
actaatgac  cttgacttc  gctgggtcc  aagtcctct  agcagtggg  gactgctgt  2400
gccaatacc  cagactcca  ggaaagaga  gaggccatc  ttctcactg  accactagg  2460
gcagttgga  ataggtggg  agaaaaggt  acttgttat  gaagattaa  actagattt  2520
atactgaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  2560



<210> 1131
<211> 429
<212> PRT
<213> Homo sapiens
<308> O43826
<400> 1131

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Ser Ala 
  1               5                  10                  15
Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
             20                  25                  30
Phe Val Met Pro Ser Leu Val Glu Glu Ile Pro Leu Asp Lys Asp Asp 
         35                  40                  45
Leu Gly Phe Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
     50                  55                  60
Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
 65                  70                  75                  80
Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Ile Phe Phe Ala Trp 
                 85                  90                  95
Ser Ser Thr Val Pro Val Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
             100                105                110
Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Val Leu Arg Lys Trp 
         115                120                125
Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Ile Leu Ser Thr Ser 
     130                135                140
Met Asn Leu Ala Gly Gly Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
 145                150                155                160
Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ala Leu Cys 
                 165                170                175
Val Val Val Ser Phe Leu Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
             180                185                190
Asp Val Gly Leu Arg Asn Leu Asp Pro Met Pro Ser Glu Gly Lys Lys 
         195                200                205
Gly Ser Leu Lys Glu Glu Ser Thr Leu Gln Glu Leu Leu Leu Ser Pro 
     210                215                220
Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
 225                230                235                240
Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Lys Gly 
                 245                250                255
Gln Ser Ala Leu Val Gly Ser Ser Tyr Met Ser Ala Leu Glu Val Gly 
             260                265                270
Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
         275                280                285
Ala Lys Ala Gly Leu Ser Asn Tyr Gly Asn Pro Arg His Gly Leu Leu 
     290                295                300
Leu Phe Met Met Ala Gly Met Thr Val Ser Met Tyr Leu Phe Arg Val 
 305                310                315                320
Thr Val Thr Ser Asp Ser Pro Lys Leu Trp Ile Leu Val Leu Gly Ala 
                 325                330                335
Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
             340                345                350
Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
         355                360                365
Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
     370                375                380
Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
 385                390                395                400
Glu Val Ile Cys Ala Ala Ser Thr Ala Ala Phe Phe Leu Leu Arg Asn 
                 405                410                415
Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
             420                425



<210> 1132
<211> 1930
<212> DNA
<213> Rattus norvegicus
<308> AF080468
<400> 1132

aaaaacaca  ctcagcaga  ccgggcact  gagagggag  tgcaagcag  agcagtcaa  60
agtgtggtc  gaagcaccg  gagtggacc  gcagggccg  ctttttcta  catggcggc  120
caaggctat  gctattacc  cactgtcat  ttcacagcc  tgttcggag  ctacagcct  180
tactacttc  accgcaaaa  cttctcttt  gtcatgccc  ccttggtgg  tgagatcgc  240
ctggacaag  acgatttgg  gctcatcac  agcagccag  cggcagcct  cgccatcag  300
aagtttgtg  gcggggtgc  gtctgatca  atgagtgcc  gttggctct  ctcctctgg  360
ctgctcctg  ttggtctgg  caacgtagt  ttctcgtgg  gctctacag  accggcttt  420
gctgctctc  ggtttctta  tggtctggc  caggggcta  gctggcccc  ctgtgggaa  480
atcctgagg  agtggtttg  gccatccca  tttggtact  ggtgggctg  gttgtcaac  540
agcatgaac  tggctggaa  cctgggacc  atcttggcg  caatccttg  tcagagcta  600
agctggcgc  gcaccctgg  cctgtctgg  tcactgtgt  tggttgtct  cttcttctg  660
ctcctgctc  tccacaacg  acctgctga  gttggactc  gaaatctgg  ccctcgccc  720
tccaagggc  aaaagggct  gtcaaagga  gagagcacc  tacaggacc  gctgctgtc  780
ccctatctc  gggtgctct  cactggcta  ctcgtggtc  ttggggtaa  gacttgctg  840
acagactgg  gccagttct  ccttatcca  gagagaggg  agtcggccc  tgtgggtag  900
tcctacatc  gtgccctag  ggttggagg  cttgtaggc  gcattgcag  tggctatct  960
tcagacagg  ctatggcaa  ggcagggct  tctgtgtat  ggaaccctc  ccacagcct  1020
ttgctgctc  tgatggctg  catggcagc  tccatgttc  tcttccggg  aacagtgac  1080
agcgactct  ccaagatct  gatcctggt  ttgggagct  tatttggtt  ctcttctta  1140
ggtcccatt  ccttgtttg  agtcatagc  aatgagagt  cacctccca  cttgtgtgg  1200
acctctcat  ctattgtgg  gctcatggc  aatgtgggt  gatttctgg  tgggttacc  1260
ttcagtacc  tcgccaagc  ctatagctg  agcacagcc  tctgggtgg  agaagtgat  1320
tgtatagcc  gcacagttg  cttcttctt  cttcgaaat  tccgcacca  gatgggccg  1380
gtatccaag  aggcagagt  aaaagagca  tcactatag  gcatcccca  ctgcaacct  1440
attggcagg  cacagaaag  aagagaggc  gctctggct  gaacagagc  tttacatat  1500
tgtgtctac  ctgtctctc  ggacctccg  ggtgctgca  gttaccagt  gctaatgag  1560
tcctatgct  tatttaaat  atgtttggt  ttaggctcc  ttggcttct  tttctacct  1620
ctagcagac  gacaactcc  aaattcagg  tgtctccta  acccctctt  ctctcctga  1680
tccccatct  ctagtgagg  ggttctatc  ctgcagctg  agaatatta  tggcctgtg  1740
tttctgctg  accccaagg  ttcttgtta  gggtcaaca  tgttgccaa  acctcagtc  1800
ctaagggag  agaggaggc  accactctc  tcagttacc  ggggacaaa  gggaggaat  1860
tagagagca  actgtcttg  atagactaa  aaaactaga  ttgatacta  aaaaaaaaa  1920
aaaaaaaaaa  1930



<210> 1133
<211> 429
<212> PRT
<213> Rattus norvegicus
<308> AAC79839
<400> 1133

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Thr Ala 
  1               5                  10                  15
Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
             20                  25                  30
Phe Val Met Pro Ser Leu Val Asp Glu Ile Ala Leu Asp Lys Asp Asp 
         35                  40                  45
Leu Gly Leu Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
     50                  55                  60
Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
 65                  70                  75                  80
Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Val Val Phe Ser Trp 
                 85                  90                  95
Ser Ser Thr Val Pro Ala Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
             100                105                110
Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Ile Leu Arg Lys Trp 
         115                120                125
Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Val Leu Ser Thr Ser 
     130                135                140
Met Asn Leu Ala Gly Ser Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
 145                150                155                160
Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ser Leu Cys 
                 165                170                175
Val Val Val Ser Phe Phe Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
             180                185                190
Asp Val Gly Leu Arg Asn Leu Asp Pro Arg Pro Ser Lys Gly Lys Lys 
         195                200                205
Gly Ser Ser Lys Glu Glu Ser Thr Leu Gln Asp Leu Leu Leu Ser Pro 
     210                215                220
Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
 225                230                235                240
Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Arg Gly 
                 245                250                255
Gln Ser Ala Leu Val Gly Ser Ser Tyr Ile Ser Ala Leu Glu Val Gly 
             260                265                270
Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
         275                280                285
Ala Lys Ala Gly Leu Ser Val Tyr Gly Asn Pro Arg His Ser Leu Leu 
     290                295                300
Leu Leu Met Met Ala Gly Met Ala Ala Ser Met Phe Leu Phe Arg Val 
 305                310                315                320
Thr Val Thr Ser Asp Ser Pro Lys Ile Trp Ile Leu Val Leu Gly Ala 
                 325                330                335
Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
             340                345                350
Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
         355                360                365
Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
     370                375                380
Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
 385                390                395                400
Glu Val Ile Cys Ile Ala Ser Thr Val Val Phe Phe Leu Leu Arg Asn 
                 405                410                415
Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
             420                425



<210> 1134
<211> 2560
<212> DNA
<213> Homo sapiens
<308> NM_001467
<400> 1134

ggcacgagg  gccaccgag  cgctgtccc  gaccaccag  acgagaccc  tttctatcg  60
gccagtcct  tggtctccg  acctctcca  ctcctgcac  cccggcccc  gtggttccc  120
gccgcacag  agcgtgtcc  gggtagcgt  aggacccac  gggctgagc  ggtgccacg  180
gcccgccgc  tcttcgccg  ccgccgcct  tcctcctct  ccgcccgcc  cctggccct  240
ccctaccag  ctgagcctc  ggctgccag  agcgcgggg  ctccgggag  atacgtgcg  300
tcgcccgct  cgcgtgcgc  tacgccttc  gctccagtt  ctttcccaa  tgagcggaa  360
agccggggc  tgttgccgg  gccctgggc  ggacggttg  gccctgcag  ccgaagccc  420
ccggggcac  ttcccgccc  cgagctgcc  agtccctct  cttgcggcc  ctgccaacg  480
cccacagga  actgggtcc  cttggagcc  ccccaggct  aatgattgt  cagaaggcg  540
ctataaagg  agcctggga  gctgggtgg  ggagggagc  gaaaaaacc  aactcagca  600
atctgggaa  tgtgagagc  gcaagcagg  actgtggtc  gaggctgtg  gtcttggct  660
gtagggcct  ctcttttct  ccatggcag  ccagggcta  ggctattat  gcactgtga  720
cttctcagc  atgtttggg  gctacagcc  gtattactt  aatcgcaag  ccttctcct  780
tgtcatgcc  tcattggtg  aagagatcc  tttggacaa  gatgatttg  ggttcatca  840
cagcagcca  tcggcagct  atgctatca  caagtttgt  agtggggtg  tgtctgacc  900
gatgagtgc  cgctggctc  tctcttctg  gctgctcct  gttggcctg  tcaacatat  960
ctttgcctg  agctccaca  tacctgtct  tgctgccct  tggttcctt  atggcctgg  1020
ccaggggct  ggctggccc  catgtggga  ggtcctgcg  aagtggttt  agccatctc  1080
gtttggcac  tggtgggcc  tcctgtcaa  cagcatgaa  ctggctgga  ggctgggcc  1140
tatcctggc  accatcctt  cccagagct  cagctggcg  agcacgctg  ccctatctg  1200
ggcactgtg  gtggttgtc  ccttcctct  tctcctgct  atccacaat  aacctgctg  1260
tgttggact  cgcaacctg  accccatgc  ctctgaggg  aagaagggc  ccttgaagg  1320
ggagagcac  ctgcaggag  tgctgctgt  cccttacct  tgggtgctc  ccactggtt  1380
ccttgtggt  tttggagta  agacctgct  tactgactg  ggccagttc  tccttatcc  1440
ggagaaagg  cagtcagcc  ttgtaggta  ctcctacat  agtgccctg  aagttgggg  1500
ccttgtagg  agcatcgca  ctggctacc  gtcagaccg  gccatggca  aggcgggac  1560
gtccaacta  gggaaccct  gccatggcc  gttgctgtt  atgatggct  gcatgacag  1620
gtccatgta  ctcttccgg  taacagtga  cagtgactc  cccaagctc  ggatcctgg  1680
attgggagc  gtatttggt  tctcctcgt  tggccccat  gccctgttt  gagtcatag  1740
caacgagag  gcccctccc  acttgtgtg  cacctccca  gccattgtg  gactcatgg  1800
caatgtggg  ggctttctg  ctgggctgc  cttcagcac  attgccaag  actacagtt  1860
gagcacagc  ttctgggtg  ctgaagtga  ttgtgcggc  agcacggct  ccttcttcc  1920
cctacgaaa  atccgcacc  agatgggcc  agtgtccaa  aaggctgag  gaagagagt  1980
caggttccg  agcaccatc  cacggtggc  ttccccctg  acgctctgc  gggagaaaa  2040
gaggggcct  cctggctag  cctgaacct  tcactttcc  tttctgcgc  ttttctgtc  2100
cccgggtgg  gctggaagt  atcagtggc  agtgaggtc  cagctccct  atcctatgc  2160
ctatttaaa  gataacctt  ggccttaga  tccgttagc  cctatttcc  gccttcaga  2220
aaacaggaa  cttctgcag  caggaaggc  cctgtaccc  tcttctttt  ctaggccct  2280
tcctgcccg  atcctaccc  atccccacc  gaagtgagg  tatccctgc  gctgcaggg  2340
actaatgac  cttgacttc  gctgggtcc  aagtcctct  agcagtggg  gactgctgt  2400
gccaatacc  cagactcca  ggaaagaga  gaggccatc  ttctcactg  accactagg  2460
gcagttgga  ataggtggg  agaaaaggt  acttgttat  gaagattaa  actagattt  2520
atactgaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  2560



<210> 1135
<211> 429
<212> PRT
<213> Homo sapiens
<308> O43826
<400> 1135

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Ser Ala 
  1               5                  10                  15
Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
             20                  25                  30
Phe Val Met Pro Ser Leu Val Glu Glu Ile Pro Leu Asp Lys Asp Asp 
         35                  40                  45
Leu Gly Phe Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
     50                  55                  60
Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
 65                  70                  75                  80
Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Ile Phe Phe Ala Trp 
                 85                  90                  95
Ser Ser Thr Val Pro Val Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
             100                105                110
Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Val Leu Arg Lys Trp 
         115                120                125
Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Ile Leu Ser Thr Ser 
     130                135                140
Met Asn Leu Ala Gly Gly Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
 145                150                155                160
Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ala Leu Cys 
                 165                170                175
Val Val Val Ser Phe Leu Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
             180                185                190
Asp Val Gly Leu Arg Asn Leu Asp Pro Met Pro Ser Glu Gly Lys Lys 
         195                200                205
Gly Ser Leu Lys Glu Glu Ser Thr Leu Gln Glu Leu Leu Leu Ser Pro 
     210                215                220
Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
 225                230                235                240
Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Lys Gly 
                 245                250                255
Gln Ser Ala Leu Val Gly Ser Ser Tyr Met Ser Ala Leu Glu Val Gly 
             260                265                270
Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
         275                280                285
Ala Lys Ala Gly Leu Ser Asn Tyr Gly Asn Pro Arg His Gly Leu Leu 
     290                295                300
Leu Phe Met Met Ala Gly Met Thr Val Ser Met Tyr Leu Phe Arg Val 
 305                310                315                320
Thr Val Thr Ser Asp Ser Pro Lys Leu Trp Ile Leu Val Leu Gly Ala 
                 325                330                335
Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
             340                345                350
Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
         355                360                365
Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
     370                375                380
Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
 385                390                395                400
Glu Val Ile Cys Ala Ala Ser Thr Ala Ala Phe Phe Leu Leu Arg Asn 
                 405                410                415
Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
             420                425



<210> 1136
<211> 1930
<212> DNA
<213> Rattus norvegicus
<308> AF080468
<400> 1136

aaaaacaca  ctcagcaga  ccgggcact  gagagggag  tgcaagcag  agcagtcaa  60
agtgtggtc  gaagcaccg  gagtggacc  gcagggccg  ctttttcta  catggcggc  120
caaggctat  gctattacc  cactgtcat  ttcacagcc  tgttcggag  ctacagcct  180
tactacttc  accgcaaaa  cttctcttt  gtcatgccc  ccttggtgg  tgagatcgc  240
ctggacaag  acgatttgg  gctcatcac  agcagccag  cggcagcct  cgccatcag  300
aagtttgtg  gcggggtgc  gtctgatca  atgagtgcc  gttggctct  ctcctctgg  360
ctgctcctg  ttggtctgg  caacgtagt  ttctcgtgg  gctctacag  accggcttt  420
gctgctctc  ggtttctta  tggtctggc  caggggcta  gctggcccc  ctgtgggaa  480
atcctgagg  agtggtttg  gccatccca  tttggtact  ggtgggctg  gttgtcaac  540
agcatgaac  tggctggaa  cctgggacc  atcttggcg  caatccttg  tcagagcta  600
agctggcgc  gcaccctgg  cctgtctgg  tcactgtgt  tggttgtct  cttcttctg  660
ctcctgctc  tccacaacg  acctgctga  gttggactc  gaaatctgg  ccctcgccc  720
tccaagggc  aaaagggct  gtcaaagga  gagagcacc  tacaggacc  gctgctgtc  780
ccctatctc  gggtgctct  cactggcta  ctcgtggtc  ttggggtaa  gacttgctg  840
acagactgg  gccagttct  ccttatcca  gagagaggg  agtcggccc  tgtgggtag  900
tcctacatc  gtgccctag  ggttggagg  cttgtaggc  gcattgcag  tggctatct  960
tcagacagg  ctatggcaa  ggcagggct  tctgtgtat  ggaaccctc  ccacagcct  1020
ttgctgctc  tgatggctg  catggcagc  tccatgttc  tcttccggg  aacagtgac  1080
agcgactct  ccaagatct  gatcctggt  ttgggagct  tatttggtt  ctcttctta  1140
ggtcccatt  ccttgtttg  agtcatagc  aatgagagt  cacctccca  cttgtgtgg  1200
acctctcat  ctattgtgg  gctcatggc  aatgtgggt  gatttctgg  tgggttacc  1260
ttcagtacc  tcgccaagc  ctatagctg  agcacagcc  tctgggtgg  agaagtgat  1320
tgtatagcc  gcacagttg  cttcttctt  cttcgaaat  tccgcacca  gatgggccg  1380
gtatccaag  aggcagagt  aaaagagca  tcactatag  gcatcccca  ctgcaacct  1440
attggcagg  cacagaaag  aagagaggc  gctctggct  gaacagagc  tttacatat  1500
tgtgtctac  ctgtctctc  ggacctccg  ggtgctgca  gttaccagt  gctaatgag  1560
tcctatgct  tatttaaat  atgtttggt  ttaggctcc  ttggcttct  tttctacct  1620
ctagcagac  gacaactcc  aaattcagg  tgtctccta  acccctctt  ctctcctga  1680
tccccatct  ctagtgagg  ggttctatc  ctgcagctg  agaatatta  tggcctgtg  1740
tttctgctg  accccaagg  ttcttgtta  gggtcaaca  tgttgccaa  acctcagtc  1800
ctaagggag  agaggaggc  accactctc  tcagttacc  ggggacaaa  gggaggaat  1860
tagagagca  actgtcttg  atagactaa  aaaactaga  ttgatacta  aaaaaaaaa  1920
aaaaaaaaaa  1930



<210> 1137
<211> 429
<212> PRT
<213> Rattus norvegicus
<308> AAC79839
<400> 1137

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Thr Ala 
  1               5                  10                  15
Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
             20                  25                  30
Phe Val Met Pro Ser Leu Val Asp Glu Ile Ala Leu Asp Lys Asp Asp 
         35                  40                  45
Leu Gly Leu Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
     50                  55                  60
Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
 65                  70                  75                  80
Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Val Val Phe Ser Trp 
                 85                  90                  95
Ser Ser Thr Val Pro Ala Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
             100                105                110
Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Ile Leu Arg Lys Trp 
         115                120                125
Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Val Leu Ser Thr Ser 
     130                135                140
Met Asn Leu Ala Gly Ser Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
 145                150                155                160
Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ser Leu Cys 
                 165                170                175
Val Val Val Ser Phe Phe Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
             180                185                190
Asp Val Gly Leu Arg Asn Leu Asp Pro Arg Pro Ser Lys Gly Lys Lys 
         195                200                205
Gly Ser Ser Lys Glu Glu Ser Thr Leu Gln Asp Leu Leu Leu Ser Pro 
     210                215                220
Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
 225                230                235                240
Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Arg Gly 
                 245                250                255
Gln Ser Ala Leu Val Gly Ser Ser Tyr Ile Ser Ala Leu Glu Val Gly 
             260                265                270
Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
         275                280                285
Ala Lys Ala Gly Leu Ser Val Tyr Gly Asn Pro Arg His Ser Leu Leu 
     290                295                300
Leu Leu Met Met Ala Gly Met Ala Ala Ser Met Phe Leu Phe Arg Val 
 305                310                315                320
Thr Val Thr Ser Asp Ser Pro Lys Ile Trp Ile Leu Val Leu Gly Ala 
                 325                330                335
Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
             340                345                350
Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
         355                360                365
Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
     370                375                380
Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
 385                390                395                400
Glu Val Ile Cys Ile Ala Ser Thr Val Val Phe Phe Leu Leu Arg Asn 
                 405                410                415
Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
             420                425



<210> 1138
<211> 2560
<212> DNA
<213> Homo sapiens
<308> NM_001467
<400> 1138

ggcacgagg  gccaccgag  cgctgtccc  gaccaccag  acgagaccc  tttctatcg  60
gccagtcct  tggtctccg  acctctcca  ctcctgcac  cccggcccc  gtggttccc  120
gccgcacag  agcgtgtcc  gggtagcgt  aggacccac  gggctgagc  ggtgccacg  180
gcccgccgc  tcttcgccg  ccgccgcct  tcctcctct  ccgcccgcc  cctggccct  240
ccctaccag  ctgagcctc  ggctgccag  agcgcgggg  ctccgggag  atacgtgcg  300
tcgcccgct  cgcgtgcgc  tacgccttc  gctccagtt  ctttcccaa  tgagcggaa  360
agccggggc  tgttgccgg  gccctgggc  ggacggttg  gccctgcag  ccgaagccc  420
ccggggcac  ttcccgccc  cgagctgcc  agtccctct  cttgcggcc  ctgccaacg  480
cccacagga  actgggtcc  cttggagcc  ccccaggct  aatgattgt  cagaaggcg  540
ctataaagg  agcctggga  gctgggtgg  ggagggagc  gaaaaaacc  aactcagca  600
atctgggaa  tgtgagagc  gcaagcagg  actgtggtc  gaggctgtg  gtcttggct  660
gtagggcct  ctcttttct  ccatggcag  ccagggcta  ggctattat  gcactgtga  720
cttctcagc  atgtttggg  gctacagcc  gtattactt  aatcgcaag  ccttctcct  780
tgtcatgcc  tcattggtg  aagagatcc  tttggacaa  gatgatttg  ggttcatca  840
cagcagcca  tcggcagct  atgctatca  caagtttgt  agtggggtg  tgtctgacc  900
gatgagtgc  cgctggctc  tctcttctg  gctgctcct  gttggcctg  tcaacatat  960
ctttgcctg  agctccaca  tacctgtct  tgctgccct  tggttcctt  atggcctgg  1020
ccaggggct  ggctggccc  catgtggga  ggtcctgcg  aagtggttt  agccatctc  1080
gtttggcac  tggtgggcc  tcctgtcaa  cagcatgaa  ctggctgga  ggctgggcc  1140
tatcctggc  accatcctt  cccagagct  cagctggcg  agcacgctg  ccctatctg  1200
ggcactgtg  gtggttgtc  ccttcctct  tctcctgct  atccacaat  aacctgctg  1260
tgttggact  cgcaacctg  accccatgc  ctctgaggg  aagaagggc  ccttgaagg  1320
ggagagcac  ctgcaggag  tgctgctgt  cccttacct  tgggtgctc  ccactggtt  1380
ccttgtggt  tttggagta  agacctgct  tactgactg  ggccagttc  tccttatcc  1440
ggagaaagg  cagtcagcc  ttgtaggta  ctcctacat  agtgccctg  aagttgggg  1500
ccttgtagg  agcatcgca  ctggctacc  gtcagaccg  gccatggca  aggcgggac  1560
gtccaacta  gggaaccct  gccatggcc  gttgctgtt  atgatggct  gcatgacag  1620
gtccatgta  ctcttccgg  taacagtga  cagtgactc  cccaagctc  ggatcctgg  1680
attgggagc  gtatttggt  tctcctcgt  tggccccat  gccctgttt  gagtcatag  1740
caacgagag  gcccctccc  acttgtgtg  cacctccca  gccattgtg  gactcatgg  1800
caatgtggg  ggctttctg  ctgggctgc  cttcagcac  attgccaag  actacagtt  1860
gagcacagc  ttctgggtg  ctgaagtga  ttgtgcggc  agcacggct  ccttcttcc  1920
cctacgaaa  atccgcacc  agatgggcc  agtgtccaa  aaggctgag  gaagagagt  1980
caggttccg  agcaccatc  cacggtggc  ttccccctg  acgctctgc  gggagaaaa  2040
gaggggcct  cctggctag  cctgaacct  tcactttcc  tttctgcgc  ttttctgtc  2100
cccgggtgg  gctggaagt  atcagtggc  agtgaggtc  cagctccct  atcctatgc  2160
ctatttaaa  gataacctt  ggccttaga  tccgttagc  cctatttcc  gccttcaga  2220
aaacaggaa  cttctgcag  caggaaggc  cctgtaccc  tcttctttt  ctaggccct  2280
tcctgcccg  atcctaccc  atccccacc  gaagtgagg  tatccctgc  gctgcaggg  2340
actaatgac  cttgacttc  gctgggtcc  aagtcctct  agcagtggg  gactgctgt  2400
gccaatacc  cagactcca  ggaaagaga  gaggccatc  ttctcactg  accactagg  2460
gcagttgga  ataggtggg  agaaaaggt  acttgttat  gaagattaa  actagattt  2520
atactgaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  2560



<210> 1139
<211> 429
<212> PRT
<213> Homo sapiens
<308> O43826
<400> 1139

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Ser Ala 
  1               5                  10                  15
Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
             20                  25                  30
Phe Val Met Pro Ser Leu Val Glu Glu Ile Pro Leu Asp Lys Asp Asp 
         35                  40                  45
Leu Gly Phe Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
     50                  55                  60
Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
 65                  70                  75                  80
Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Ile Phe Phe Ala Trp 
                 85                  90                  95
Ser Ser Thr Val Pro Val Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
             100                105                110
Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Val Leu Arg Lys Trp 
         115                120                125
Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Ile Leu Ser Thr Ser 
     130                135                140
Met Asn Leu Ala Gly Gly Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
 145                150                155                160
Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ala Leu Cys 
                 165                170                175
Val Val Val Ser Phe Leu Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
             180                185                190
Asp Val Gly Leu Arg Asn Leu Asp Pro Met Pro Ser Glu Gly Lys Lys 
         195                200                205
Gly Ser Leu Lys Glu Glu Ser Thr Leu Gln Glu Leu Leu Leu Ser Pro 
     210                215                220
Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
 225                230                235                240
Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Lys Gly 
                 245                250                255
Gln Ser Ala Leu Val Gly Ser Ser Tyr Met Ser Ala Leu Glu Val Gly 
             260                265                270
Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
         275                280                285
Ala Lys Ala Gly Leu Ser Asn Tyr Gly Asn Pro Arg His Gly Leu Leu 
     290                295                300
Leu Phe Met Met Ala Gly Met Thr Val Ser Met Tyr Leu Phe Arg Val 
 305                310                315                320
Thr Val Thr Ser Asp Ser Pro Lys Leu Trp Ile Leu Val Leu Gly Ala 
                 325                330                335
Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
             340                345                350
Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
         355                360                365
Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
     370                375                380
Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
 385                390                395                400
Glu Val Ile Cys Ala Ala Ser Thr Ala Ala Phe Phe Leu Leu Arg Asn 
                 405                410                415
Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
             420                425



<210> 1140
<211> 1930
<212> DNA
<213> Rattus norvegicus
<308> AF080468
<400> 1140

aaaaacaca  ctcagcaga  ccgggcact  gagagggag  tgcaagcag  agcagtcaa  60
agtgtggtc  gaagcaccg  gagtggacc  gcagggccg  ctttttcta  catggcggc  120
caaggctat  gctattacc  cactgtcat  ttcacagcc  tgttcggag  ctacagcct  180
tactacttc  accgcaaaa  cttctcttt  gtcatgccc  ccttggtgg  tgagatcgc  240
ctggacaag  acgatttgg  gctcatcac  agcagccag  cggcagcct  cgccatcag  300
aagtttgtg  gcggggtgc  gtctgatca  atgagtgcc  gttggctct  ctcctctgg  360
ctgctcctg  ttggtctgg  caacgtagt  ttctcgtgg  gctctacag  accggcttt  420
gctgctctc  ggtttctta  tggtctggc  caggggcta  gctggcccc  ctgtgggaa  480
atcctgagg  agtggtttg  gccatccca  tttggtact  ggtgggctg  gttgtcaac  540
agcatgaac  tggctggaa  cctgggacc  atcttggcg  caatccttg  tcagagcta  600
agctggcgc  gcaccctgg  cctgtctgg  tcactgtgt  tggttgtct  cttcttctg  660
ctcctgctc  tccacaacg  acctgctga  gttggactc  gaaatctgg  ccctcgccc  720
tccaagggc  aaaagggct  gtcaaagga  gagagcacc  tacaggacc  gctgctgtc  780
ccctatctc  gggtgctct  cactggcta  ctcgtggtc  ttggggtaa  gacttgctg  840
acagactgg  gccagttct  ccttatcca  gagagaggg  agtcggccc  tgtgggtag  900
tcctacatc  gtgccctag  ggttggagg  cttgtaggc  gcattgcag  tggctatct  960
tcagacagg  ctatggcaa  ggcagggct  tctgtgtat  ggaaccctc  ccacagcct  1020
ttgctgctc  tgatggctg  catggcagc  tccatgttc  tcttccggg  aacagtgac  1080
agcgactct  ccaagatct  gatcctggt  ttgggagct  tatttggtt  ctcttctta  1140
ggtcccatt  ccttgtttg  agtcatagc  aatgagagt  cacctccca  cttgtgtgg  1200
acctctcat  ctattgtgg  gctcatggc  aatgtgggt  gatttctgg  tgggttacc  1260
ttcagtacc  tcgccaagc  ctatagctg  agcacagcc  tctgggtgg  agaagtgat  1320
tgtatagcc  gcacagttg  cttcttctt  cttcgaaat  tccgcacca  gatgggccg  1380
gtatccaag  aggcagagt  aaaagagca  tcactatag  gcatcccca  ctgcaacct  1440
attggcagg  cacagaaag  aagagaggc  gctctggct  gaacagagc  tttacatat  1500
tgtgtctac  ctgtctctc  ggacctccg  ggtgctgca  gttaccagt  gctaatgag  1560
tcctatgct  tatttaaat  atgtttggt  ttaggctcc  ttggcttct  tttctacct  1620
ctagcagac  gacaactcc  aaattcagg  tgtctccta  acccctctt  ctctcctga  1680
tccccatct  ctagtgagg  ggttctatc  ctgcagctg  agaatatta  tggcctgtg  1740
tttctgctg  accccaagg  ttcttgtta  gggtcaaca  tgttgccaa  acctcagtc  1800
ctaagggag  agaggaggc  accactctc  tcagttacc  ggggacaaa  gggaggaat  1860
tagagagca  actgtcttg  atagactaa  aaaactaga  ttgatacta  aaaaaaaaa  1920
aaaaaaaaaa  1930



<210> 1141
<211> 429
<212> PRT
<213> Rattus norvegicus
<308> AAC79839
<400> 1141

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Thr Ala 
  1               5                  10                  15
Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
             20                  25                  30
Phe Val Met Pro Ser Leu Val Asp Glu Ile Ala Leu Asp Lys Asp Asp 
         35                  40                  45
Leu Gly Leu Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
     50                  55                  60
Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
 65                  70                  75                  80
Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Val Val Phe Ser Trp 
                 85                  90                  95
Ser Ser Thr Val Pro Ala Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
             100                105                110
Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Ile Leu Arg Lys Trp 
         115                120                125
Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Val Leu Ser Thr Ser 
     130                135                140
Met Asn Leu Ala Gly Ser Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
 145                150                155                160
Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ser Leu Cys 
                 165                170                175
Val Val Val Ser Phe Phe Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
             180                185                190
Asp Val Gly Leu Arg Asn Leu Asp Pro Arg Pro Ser Lys Gly Lys Lys 
         195                200                205
Gly Ser Ser Lys Glu Glu Ser Thr Leu Gln Asp Leu Leu Leu Ser Pro 
     210                215                220
Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
 225                230                235                240
Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Arg Gly 
                 245                250                255
Gln Ser Ala Leu Val Gly Ser Ser Tyr Ile Ser Ala Leu Glu Val Gly 
             260                265                270
Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
         275                280                285
Ala Lys Ala Gly Leu Ser Val Tyr Gly Asn Pro Arg His Ser Leu Leu 
     290                295                300
Leu Leu Met Met Ala Gly Met Ala Ala Ser Met Phe Leu Phe Arg Val 
 305                310                315                320
Thr Val Thr Ser Asp Ser Pro Lys Ile Trp Ile Leu Val Leu Gly Ala 
                 325                330                335
Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
             340                345                350
Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
         355                360                365
Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
     370                375                380
Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
 385                390                395                400
Glu Val Ile Cys Ile Ala Ser Thr Val Val Phe Phe Leu Leu Arg Asn 
                 405                410                415
Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
             420                425



<210> 1142
<211> 2560
<212> DNA
<213> Homo sapiens
<308> NM_001467
<400> 1142

ggcacgagg  gccaccgag  cgctgtccc  gaccaccag  acgagaccc  tttctatcg  60
gccagtcct  tggtctccg  acctctcca  ctcctgcac  cccggcccc  gtggttccc  120
gccgcacag  agcgtgtcc  gggtagcgt  aggacccac  gggctgagc  ggtgccacg  180
gcccgccgc  tcttcgccg  ccgccgcct  tcctcctct  ccgcccgcc  cctggccct  240
ccctaccag  ctgagcctc  ggctgccag  agcgcgggg  ctccgggag  atacgtgcg  300
tcgcccgct  cgcgtgcgc  tacgccttc  gctccagtt  ctttcccaa  tgagcggaa  360
agccggggc  tgttgccgg  gccctgggc  ggacggttg  gccctgcag  ccgaagccc  420
ccggggcac  ttcccgccc  cgagctgcc  agtccctct  cttgcggcc  ctgccaacg  480
cccacagga  actgggtcc  cttggagcc  ccccaggct  aatgattgt  cagaaggcg  540
ctataaagg  agcctggga  gctgggtgg  ggagggagc  gaaaaaacc  aactcagca  600
atctgggaa  tgtgagagc  gcaagcagg  actgtggtc  gaggctgtg  gtcttggct  660
gtagggcct  ctcttttct  ccatggcag  ccagggcta  ggctattat  gcactgtga  720
cttctcagc  atgtttggg  gctacagcc  gtattactt  aatcgcaag  ccttctcct  780
tgtcatgcc  tcattggtg  aagagatcc  tttggacaa  gatgatttg  ggttcatca  840
cagcagcca  tcggcagct  atgctatca  caagtttgt  agtggggtg  tgtctgacc  900
gatgagtgc  cgctggctc  tctcttctg  gctgctcct  gttggcctg  tcaacatat  960
ctttgcctg  agctccaca  tacctgtct  tgctgccct  tggttcctt  atggcctgg  1020
ccaggggct  ggctggccc  catgtggga  ggtcctgcg  aagtggttt  agccatctc  1080
gtttggcac  tggtgggcc  tcctgtcaa  cagcatgaa  ctggctgga  ggctgggcc  1140
tatcctggc  accatcctt  cccagagct  cagctggcg  agcacgctg  ccctatctg  1200
ggcactgtg  gtggttgtc  ccttcctct  tctcctgct  atccacaat  aacctgctg  1260
tgttggact  cgcaacctg  accccatgc  ctctgaggg  aagaagggc  ccttgaagg  1320
ggagagcac  ctgcaggag  tgctgctgt  cccttacct  tgggtgctc  ccactggtt  1380
ccttgtggt  tttggagta  agacctgct  tactgactg  ggccagttc  tccttatcc  1440
ggagaaagg  cagtcagcc  ttgtaggta  ctcctacat  agtgccctg  aagttgggg  1500
ccttgtagg  agcatcgca  ctggctacc  gtcagaccg  gccatggca  aggcgggac  1560
gtccaacta  gggaaccct  gccatggcc  gttgctgtt  atgatggct  gcatgacag  1620
gtccatgta  ctcttccgg  taacagtga  cagtgactc  cccaagctc  ggatcctgg  1680
attgggagc  gtatttggt  tctcctcgt  tggccccat  gccctgttt  gagtcatag  1740
caacgagag  gcccctccc  acttgtgtg  cacctccca  gccattgtg  gactcatgg  1800
caatgtggg  ggctttctg  ctgggctgc  cttcagcac  attgccaag  actacagtt  1860
gagcacagc  ttctgggtg  ctgaagtga  ttgtgcggc  agcacggct  ccttcttcc  1920
cctacgaaa  atccgcacc  agatgggcc  agtgtccaa  aaggctgag  gaagagagt  1980
caggttccg  agcaccatc  cacggtggc  ttccccctg  acgctctgc  gggagaaaa  2040
gaggggcct  cctggctag  cctgaacct  tcactttcc  tttctgcgc  ttttctgtc  2100
cccgggtgg  gctggaagt  atcagtggc  agtgaggtc  cagctccct  atcctatgc  2160
ctatttaaa  gataacctt  ggccttaga  tccgttagc  cctatttcc  gccttcaga  2220
aaacaggaa  cttctgcag  caggaaggc  cctgtaccc  tcttctttt  ctaggccct  2280
tcctgcccg  atcctaccc  atccccacc  gaagtgagg  tatccctgc  gctgcaggg  2340
actaatgac  cttgacttc  gctgggtcc  aagtcctct  agcagtggg  gactgctgt  2400
gccaatacc  cagactcca  ggaaagaga  gaggccatc  ttctcactg  accactagg  2460
gcagttgga  ataggtggg  agaaaaggt  acttgttat  gaagattaa  actagattt  2520
atactgaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  2560



<210> 1143
<211> 429
<212> PRT
<213> Homo sapiens
<308> O43826
<400> 1143

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Ser Ala 
  1               5                  10                  15
Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
             20                  25                  30
Phe Val Met Pro Ser Leu Val Glu Glu Ile Pro Leu Asp Lys Asp Asp 
         35                  40                  45
Leu Gly Phe Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
     50                  55                  60
Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
 65                  70                  75                  80
Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Ile Phe Phe Ala Trp 
                 85                  90                  95
Ser Ser Thr Val Pro Val Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
             100                105                110
Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Val Leu Arg Lys Trp 
         115                120                125
Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Ile Leu Ser Thr Ser 
     130                135                140
Met Asn Leu Ala Gly Gly Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
 145                150                155                160
Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ala Leu Cys 
                 165                170                175
Val Val Val Ser Phe Leu Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
             180                185                190
Asp Val Gly Leu Arg Asn Leu Asp Pro Met Pro Ser Glu Gly Lys Lys 
         195                200                205
Gly Ser Leu Lys Glu Glu Ser Thr Leu Gln Glu Leu Leu Leu Ser Pro 
     210                215                220
Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
 225                230                235                240
Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Lys Gly 
                 245                250                255
Gln Ser Ala Leu Val Gly Ser Ser Tyr Met Ser Ala Leu Glu Val Gly 
             260                265                270
Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
         275                280                285
Ala Lys Ala Gly Leu Ser Asn Tyr Gly Asn Pro Arg His Gly Leu Leu 
     290                295                300
Leu Phe Met Met Ala Gly Met Thr Val Ser Met Tyr Leu Phe Arg Val 
 305                310                315                320
Thr Val Thr Ser Asp Ser Pro Lys Leu Trp Ile Leu Val Leu Gly Ala 
                 325                330                335
Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
             340                345                350
Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
         355                360                365
Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
     370                375                380
Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
 385                390                395                400
Glu Val Ile Cys Ala Ala Ser Thr Ala Ala Phe Phe Leu Leu Arg Asn 
                 405                410                415
Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
             420                425



<210> 1144
<211> 1930
<212> DNA
<213> Rattus norvegicus
<308> AF080468
<400> 1144

aaaaacaca  ctcagcaga  ccgggcact  gagagggag  tgcaagcag  agcagtcaa  60
agtgtggtc  gaagcaccg  gagtggacc  gcagggccg  ctttttcta  catggcggc  120
caaggctat  gctattacc  cactgtcat  ttcacagcc  tgttcggag  ctacagcct  180
tactacttc  accgcaaaa  cttctcttt  gtcatgccc  ccttggtgg  tgagatcgc  240
ctggacaag  acgatttgg  gctcatcac  agcagccag  cggcagcct  cgccatcag  300
aagtttgtg  gcggggtgc  gtctgatca  atgagtgcc  gttggctct  ctcctctgg  360
ctgctcctg  ttggtctgg  caacgtagt  ttctcgtgg  gctctacag  accggcttt  420
gctgctctc  ggtttctta  tggtctggc  caggggcta  gctggcccc  ctgtgggaa  480
atcctgagg  agtggtttg  gccatccca  tttggtact  ggtgggctg  gttgtcaac  540
agcatgaac  tggctggaa  cctgggacc  atcttggcg  caatccttg  tcagagcta  600
agctggcgc  gcaccctgg  cctgtctgg  tcactgtgt  tggttgtct  cttcttctg  660
ctcctgctc  tccacaacg  acctgctga  gttggactc  gaaatctgg  ccctcgccc  720
tccaagggc  aaaagggct  gtcaaagga  gagagcacc  tacaggacc  gctgctgtc  780
ccctatctc  gggtgctct  cactggcta  ctcgtggtc  ttggggtaa  gacttgctg  840
acagactgg  gccagttct  ccttatcca  gagagaggg  agtcggccc  tgtgggtag  900
tcctacatc  gtgccctag  ggttggagg  cttgtaggc  gcattgcag  tggctatct  960
tcagacagg  ctatggcaa  ggcagggct  tctgtgtat  ggaaccctc  ccacagcct  1020
ttgctgctc  tgatggctg  catggcagc  tccatgttc  tcttccggg  aacagtgac  1080
agcgactct  ccaagatct  gatcctggt  ttgggagct  tatttggtt  ctcttctta  1140
ggtcccatt  ccttgtttg  agtcatagc  aatgagagt  cacctccca  cttgtgtgg  1200
acctctcat  ctattgtgg  gctcatggc  aatgtgggt  gatttctgg  tgggttacc  1260
ttcagtacc  tcgccaagc  ctatagctg  agcacagcc  tctgggtgg  agaagtgat  1320
tgtatagcc  gcacagttg  cttcttctt  cttcgaaat  tccgcacca  gatgggccg  1380
gtatccaag  aggcagagt  aaaagagca  tcactatag  gcatcccca  ctgcaacct  1440
attggcagg  cacagaaag  aagagaggc  gctctggct  gaacagagc  tttacatat  1500
tgtgtctac  ctgtctctc  ggacctccg  ggtgctgca  gttaccagt  gctaatgag  1560
tcctatgct  tatttaaat  atgtttggt  ttaggctcc  ttggcttct  tttctacct  1620
ctagcagac  gacaactcc  aaattcagg  tgtctccta  acccctctt  ctctcctga  1680
tccccatct  ctagtgagg  ggttctatc  ctgcagctg  agaatatta  tggcctgtg  1740
tttctgctg  accccaagg  ttcttgtta  gggtcaaca  tgttgccaa  acctcagtc  1800
ctaagggag  agaggaggc  accactctc  tcagttacc  ggggacaaa  gggaggaat  1860
tagagagca  actgtcttg  atagactaa  aaaactaga  ttgatacta  aaaaaaaaa  1920
aaaaaaaaaa  1930



<210> 1145
<211> 429
<212> PRT
<213> Rattus norvegicus
<308> AAC79839
<400> 1145

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Thr Ala 
  1               5                  10                  15
Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
             20                  25                  30
Phe Val Met Pro Ser Leu Val Asp Glu Ile Ala Leu Asp Lys Asp Asp 
         35                  40                  45
Leu Gly Leu Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
     50                  55                  60
Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
 65                  70                  75                  80
Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Val Val Phe Ser Trp 
                 85                  90                  95
Ser Ser Thr Val Pro Ala Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
             100                105                110
Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Ile Leu Arg Lys Trp 
         115                120                125
Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Val Leu Ser Thr Ser 
     130                135                140
Met Asn Leu Ala Gly Ser Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
 145                150                155                160
Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ser Leu Cys 
                 165                170                175
Val Val Val Ser Phe Phe Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
             180                185                190
Asp Val Gly Leu Arg Asn Leu Asp Pro Arg Pro Ser Lys Gly Lys Lys 
         195                200                205
Gly Ser Ser Lys Glu Glu Ser Thr Leu Gln Asp Leu Leu Leu Ser Pro 
     210                215                220
Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
 225                230                235                240
Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Arg Gly 
                 245                250                255
Gln Ser Ala Leu Val Gly Ser Ser Tyr Ile Ser Ala Leu Glu Val Gly 
             260                265                270
Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
         275                280                285
Ala Lys Ala Gly Leu Ser Val Tyr Gly Asn Pro Arg His Ser Leu Leu 
     290                295                300
Leu Leu Met Met Ala Gly Met Ala Ala Ser Met Phe Leu Phe Arg Val 
 305                310                315                320
Thr Val Thr Ser Asp Ser Pro Lys Ile Trp Ile Leu Val Leu Gly Ala 
                 325                330                335
Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
             340                345                350
Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
         355                360                365
Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
     370                375                380
Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
 385                390                395                400
Glu Val Ile Cys Ile Ala Ser Thr Val Val Phe Phe Leu Leu Arg Asn 
                 405                410                415
Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
             420                425



<210> 1146
<211> 2560
<212> DNA
<213> Homo sapiens
<308> NM_001467
<400> 1146

ggcacgagg  gccaccgag  cgctgtccc  gaccaccag  acgagaccc  tttctatcg  60
gccagtcct  tggtctccg  acctctcca  ctcctgcac  cccggcccc  gtggttccc  120
gccgcacag  agcgtgtcc  gggtagcgt  aggacccac  gggctgagc  ggtgccacg  180
gcccgccgc  tcttcgccg  ccgccgcct  tcctcctct  ccgcccgcc  cctggccct  240
ccctaccag  ctgagcctc  ggctgccag  agcgcgggg  ctccgggag  atacgtgcg  300
tcgcccgct  cgcgtgcgc  tacgccttc  gctccagtt  ctttcccaa  tgagcggaa  360
agccggggc  tgttgccgg  gccctgggc  ggacggttg  gccctgcag  ccgaagccc  420
ccggggcac  ttcccgccc  cgagctgcc  agtccctct  cttgcggcc  ctgccaacg  480
cccacagga  actgggtcc  cttggagcc  ccccaggct  aatgattgt  cagaaggcg  540
ctataaagg  agcctggga  gctgggtgg  ggagggagc  gaaaaaacc  aactcagca  600
atctgggaa  tgtgagagc  gcaagcagg  actgtggtc  gaggctgtg  gtcttggct  660
gtagggcct  ctcttttct  ccatggcag  ccagggcta  ggctattat  gcactgtga  720
cttctcagc  atgtttggg  gctacagcc  gtattactt  aatcgcaag  ccttctcct  780
tgtcatgcc  tcattggtg  aagagatcc  tttggacaa  gatgatttg  ggttcatca  840
cagcagcca  tcggcagct  atgctatca  caagtttgt  agtggggtg  tgtctgacc  900
gatgagtgc  cgctggctc  tctcttctg  gctgctcct  gttggcctg  tcaacatat  960
ctttgcctg  agctccaca  tacctgtct  tgctgccct  tggttcctt  atggcctgg  1020
ccaggggct  ggctggccc  catgtggga  ggtcctgcg  aagtggttt  agccatctc  1080
gtttggcac  tggtgggcc  tcctgtcaa  cagcatgaa  ctggctgga  ggctgggcc  1140
tatcctggc  accatcctt  cccagagct  cagctggcg  agcacgctg  ccctatctg  1200
ggcactgtg  gtggttgtc  ccttcctct  tctcctgct  atccacaat  aacctgctg  1260
tgttggact  cgcaacctg  accccatgc  ctctgaggg  aagaagggc  ccttgaagg  1320
ggagagcac  ctgcaggag  tgctgctgt  cccttacct  tgggtgctc  ccactggtt  1380
ccttgtggt  tttggagta  agacctgct  tactgactg  ggccagttc  tccttatcc  1440
ggagaaagg  cagtcagcc  ttgtaggta  ctcctacat  agtgccctg  aagttgggg  1500
ccttgtagg  agcatcgca  ctggctacc  gtcagaccg  gccatggca  aggcgggac  1560
gtccaacta  gggaaccct  gccatggcc  gttgctgtt  atgatggct  gcatgacag  1620
gtccatgta  ctcttccgg  taacagtga  cagtgactc  cccaagctc  ggatcctgg  1680
attgggagc  gtatttggt  tctcctcgt  tggccccat  gccctgttt  gagtcatag  1740
caacgagag  gcccctccc  acttgtgtg  cacctccca  gccattgtg  gactcatgg  1800
caatgtggg  ggctttctg  ctgggctgc  cttcagcac  attgccaag  actacagtt  1860
gagcacagc  ttctgggtg  ctgaagtga  ttgtgcggc  agcacggct  ccttcttcc  1920
cctacgaaa  atccgcacc  agatgggcc  agtgtccaa  aaggctgag  gaagagagt  1980
caggttccg  agcaccatc  cacggtggc  ttccccctg  acgctctgc  gggagaaaa  2040
gaggggcct  cctggctag  cctgaacct  tcactttcc  tttctgcgc  ttttctgtc  2100
cccgggtgg  gctggaagt  atcagtggc  agtgaggtc  cagctccct  atcctatgc  2160
ctatttaaa  gataacctt  ggccttaga  tccgttagc  cctatttcc  gccttcaga  2220
aaacaggaa  cttctgcag  caggaaggc  cctgtaccc  tcttctttt  ctaggccct  2280
tcctgcccg  atcctaccc  atccccacc  gaagtgagg  tatccctgc  gctgcaggg  2340
actaatgac  cttgacttc  gctgggtcc  aagtcctct  agcagtggg  gactgctgt  2400
gccaatacc  cagactcca  ggaaagaga  gaggccatc  ttctcactg  accactagg  2460
gcagttgga  ataggtggg  agaaaaggt  acttgttat  gaagattaa  actagattt  2520
atactgaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  2560



<210> 1147
<211> 429
<212> PRT
<213> Homo sapiens
<308> O43826
<400> 1147

Met Ala Ala Gln Gly Tyr Gly Tyr Tyr Arg Thr Val Ile Phe Ser Ala 
  1               5                  10                  15
Met Phe Gly Gly Tyr Ser Leu Tyr Tyr Phe Asn Arg Lys Thr Phe Ser 
             20                  25                  30
Phe Val Met Pro Ser Leu Val Glu Glu Ile Pro Leu Asp Lys Asp Asp 
         35                  40                  45
Leu Gly Phe Ile Thr Ser Ser Gln Ser Ala Ala Tyr Ala Ile Ser Lys 
     50                  55                  60
Phe Val Ser Gly Val Leu Ser Asp Gln Met Ser Ala Arg Trp Leu Phe 
 65                  70                  75                  80
Ser Ser Gly Leu Leu Leu Val Gly Leu Val Asn Ile Phe Phe Ala Trp 
                 85                  90                  95
Ser Ser Thr Val Pro Val Phe Ala Ala Leu Trp Phe Leu Asn Gly Leu 
             100                105                110
Ala Gln Gly Leu Gly Trp Pro Pro Cys Gly Lys Val Leu Arg Lys Trp 
         115                120                125
Phe Glu Pro Ser Gln Phe Gly Thr Trp Trp Ala Ile Leu Ser Thr Ser 
     130                135                140
Met Asn Leu Ala Gly Gly Leu Gly Pro Ile Leu Ala Thr Ile Leu Ala 
 145                150                155                160
Gln Ser Tyr Ser Trp Arg Ser Thr Leu Ala Leu Ser Gly Ala Leu Cys 
                 165                170                175
Val Val Val Ser Phe Leu Cys Leu Leu Leu Ile His Asn Glu Pro Ala 
             180                185                190
Asp Val Gly Leu Arg Asn Leu Asp Pro Met Pro Ser Glu Gly Lys Lys 
         195                200                205
Gly Ser Leu Lys Glu Glu Ser Thr Leu Gln Glu Leu Leu Leu Ser Pro 
     210                215                220
Tyr Leu Trp Val Leu Ser Thr Gly Tyr Leu Val Val Phe Gly Val Lys 
 225                230                235                240
Thr Cys Cys Thr Asp Trp Gly Gln Phe Phe Leu Ile Gln Glu Lys Gly 
                 245                250                255
Gln Ser Ala Leu Val Gly Ser Ser Tyr Met Ser Ala Leu Glu Val Gly 
             260                265                270
Gly Leu Val Gly Ser Ile Ala Ala Gly Tyr Leu Ser Asp Arg Ala Met 
         275                280                285
Ala Lys Ala Gly Leu Ser Asn Tyr Gly Asn Pro Arg His Gly Leu Leu 
     290                295                300
Leu Phe Met Met Ala Gly Met Thr Val Ser Met Tyr Leu Phe Arg Val 
 305                310                315                320
Thr Val Thr Ser Asp Ser Pro Lys Leu Trp Ile Leu Val Leu Gly Ala 
                 325                330                335
Val Phe Gly Phe Ser Ser Tyr Gly Pro Ile Ala Leu Phe Gly Val Ile 
             340                345                350
Ala Asn Glu Ser Ala Pro Pro Asn Leu Cys Gly Thr Ser His Ala Ile 
         355                360                365
Val Gly Leu Met Ala Asn Val Gly Gly Phe Leu Ala Gly Leu Pro Phe 
     370                375                380
Ser Thr Ile Ala Lys His Tyr Ser Trp Ser Thr Ala Phe Trp Val Ala 
 385                390                395                400
Glu Val Ile Cys Ala Ala Ser Thr Ala Ala Phe Phe Leu Leu Arg Asn 
                 405                410                415
Ile Arg Thr Lys Met Gly Arg Val Ser Lys Lys Ala Glu 
             420                425



<210> 1148
<211> 5564
<212> DNA
<213> Rattus norvegicus
<308> AF081144
<400> 1148

ttttaaatt  tggttggtg  cggcagtgc  gggccggag  aaagaaggg  cacggagtc  60
tccctcgct  agccacccc  tccccgctt  cccctgggc  gggctccgg  agatgtgcc  120
ggcgggggg  ccggcttcg  ggagccgcg  gaggagcgc  cacggccga  cccgaagcg  180
cgctggaca  gctggtggg  caggccttg  taccctggt  atgcggggc  aggcccccc  240
cacagtccg  tgagatcac  gtgcccgcc  ctggccttc  ccatggccc  cttggctgc  300
gcactctgg  gtctctgtg  gacgactgt  ctcgtcacc  ctgctaccc  aggcctgag  360
cgggctgga  tcccatttg  attgatgcg  cgggagcta  catgcgaag  ctaccccat  420
gagctgcgg  gcccgggca  tgacgtcat  atggtggag  atgcaaact  tgggcgcac  480
gatgacaag  tctgcgatg  cgacccttt  cagatggag  acgtgcagt  ctacctgcc  540
gacgccttc  aaatcatgt  acagagatg  aataaccga  cccagtgtg  ggtggtggc  600
ggctctgac  cctttcctg  cccctgtcc  ggaacctac  agtacctgg  ggtgcagta  660
gactgtgtc  cttacatct  cgtgtgccc  gggacactg  agaaggtgc  ggagcccac  720
tccacacat  aatcggagc  ccagtctgg  gcatggtgc  aggacccac  gcaggcagg  780
gaccgtatc  acgttatgc  ctggatccc  taccgcacg  acacactga  cgagtatgc  840
tcctgggag  actatgtgg  tgcacgcca  accaccacg  acagactgc  caaccgtgt  900
gatggcact  gctttgtgg  atatgatgg  gccgtcttc  ataacaagg  acgtactcg  960
aacattgtc  aatatgacc  gcggacccg  atcaagagc  gagaaacag  cataaacac  1020
gccaactac  acgacacct  accttatcg  tggggaggc  aaaccgaca  tgacctggc  1080
gtggatgag  acgggctgt  ggtcatcta  gccaccgag  ggaacaacg  gcgtctggt  1140
gtgagccag  tcaacccct  cacactgcg  ttcgagggc  cctgggaaa  aggctatga  1200
aagcgctca  cctccaatg  cttcatggt  tgtggtgtc  tctatgtgc  gcgctctgt  1260
tatgtggat  acgacagtg  ggcagcagg  aaccgcgtg  actatgcct  taacaccaa  1320
gcaaaccga  aggagcccg  cagtctcgc  ttccccaac  cctaccagt  tgtatcttc  1380
gttgactac  atccccggg  caaccagct  tatgtgtgg  acaactatt  cgtggtgcg  1440
tacagcctg  agtttggac  cccagatcc  agtgctggc  cagccactt  cccacctct  1500
agtaccacc  ccacagctc  gcctacgcc  ctcaccagc  cagcctcac  tgcagccac  1560
actccactc  gccgggcgc  cctcaccac  cacccagta  gtgccatca  ccagctggg  1620
cctgacctg  ctccagcca  agccccagc  cccagtacc  ggcggcctc  agcccccaa  1680
ctgcatgtg  cccctgagc  cttctgtga  ccccgagag  tccggcggg  ccagtggcc  1740
gctacccag  agggtatgc  ggtagagag  ccttgcccc  agggaactc  aggaattgc  1800
tcgttccag  gcctcccag  tctggggct  tggaatcct  ggggccctg  cctcagcaa  1860
tgcacttcc  cctgggtca  ccaagtcgc  cagaagatc  agagtggag  gaatgcagc  1920
aacattgct  gtgagctgg  ccgccacac  cggggctcc  tctatgctg  ggacgtgtc  1980
tcatcggtg  agctgatgg  gcaactgct  gatatcctg  atgcccagc  ccaggccct  2040
cggcccatt  aacgagagt  agctggcaa  aactacaat  agatgcaca  gcgagagag  2100
acctgcaag  actatatca  ggctgtggt  gagacagtg  acaacctgc  tcggccaga  2160
gcacttgag  catggaaag  catgaatgc  accgaacag  tccatacgg  caccatgct  2220
ctagatgtc  tagaggagg  tgccttcct  ctggccgac  atgtcagag  acctgctcg  2280
ttcttggct  ccaagcaga  tgtggtcct  gaggtcact  tcctgagca  agagggtca  2340
gtgcaggag  tggtgttcc  ccaggagta  gccagtgag  gctccattc  gctgtccgc  2400
aacaccatc  agcagaaca  ccgcaatgg  gtggtgaag  ttgtcttca  tctctacaa  2460
aacctgggc  tcttcttgt  cacggagaa  gccacagtg  agctggcag  tgaggcagg  2520
accggtggc  ctggaggtg  ctccctggt  gttaactca  aggtcatcg  agcatccat  2580
aataaggag  ccagccgtg  cttcctcat  gaccctgtc  tctttactg  ggcccactt  2640
gaggccaag  accacttca  tgcaaactg  tccttctgg  actactcag  gcgctccat  2700
ctgggctac  ggtcaaccc  gggctgccg  ctggtggag  ccaataaga  ccataccac  2760
tgtgcctgc  gccacctca  caacttcgc  gtgctcatg  ctcaccgag  gatctacca  2820
ggccgtatt  atgagctgt  gctgtcagt  atcacctgg  ttggcattg  catctccct  2880
gtctgtctg  ctatctgca  ctccacctt  tgcttcctg  ggggcctgc  gaccgaccg  2940
aacaccatc  acaagaacc  gtgcatcaa  ctcttcctt  cagagctgc  cttcctggt  3000
ggaatagac  aaactcagt  tgaggtcgc  tgccctatc  ttgcgggcc  gctgcacta  3060
ttcttcctg  ccgccttct  ctggctgtg  ctagagggc  tgcacctct  cctcctgct  3120
gtcgaggtg  tcgagagcg  atattcacg  accaagtac  attacctgg  cggctactg  3180
ttcccagcc  tggtggtag  catcgcagc  gccattgac  accgaagct  cggcactga  3240
aaggcctgc  ggctgaggg  ggataacta  ttcatctgg  gcttcattg  gcccgtctc  3300
tttgttatt  tggtgaacc  ggtgttcct  atggtgacc  tgcacaaga  gatccgaag  3360
tcatccgtg  tcaagcctg  ctccagccg  cttgacaac  tcaagtcct  ggcgctggg  3420
gccattgca  tgctcttcc  gctgggcct  acctgggct  tcggcctcc  cttcatcaa  3480
aaggagtca  tagtaatgg  ttacctctt  acaaccttc  acgccttcc  gggggtctt  3540
atctttgtc  ttcactgcg  cttacagaa  aaggtgcac  aggagtaca  caagtgcct  3600
cgtcactcc  actgctgca  tcgctcccc  cctgggggg  ctcacggct  ccttaagac  3660
tcagccatg  gaagtaaca  ccgctacta  acagggacc  agagccgaa  ccggaggat  3720
tggaatgac  ccgtgagga  gcagacaga  tcgtccttt  tggcagggg  catcaacag  3780
acccccacc  tgaaccgag  taccatggg  aaccaccta  tgaccaacc  tgtgctaca  3840
ccccgtggg  gcactagcc  atacaatac  ctcattgca  agtctgtgg  cttcaatcc  3900
tcctcgccc  cagtcttca  ctccccagg  agctacagg  aacctaagc  ccccttggg  3960
ggccgggaa  cctgtggca  ggacacact  ccccttaat  gcaacttca  caacagcta  4020
tccttgcga  gtggtgatt  ccctccggg  gatgggggt  ctgagccac  ccgaggccg  4080
aacctagcg  atgctgcgg  ctttgagaa  atgatcatc  cagagctgg  gcacaacaa  4140
cttcggggg  ccagtgggg  cgccaaagg  cctccacca  agcctcctg  gccacccgt  4200
ccaggagtc  gtgaggacg  ggctggtgg  cctgggggt  ctgaccggg  tgagattga  4260
cttctctac  aggccctgg  ggagccact  ctgctgccc  gggcccagt  ggtgctgta  4320
cagagtgat  tggatgagt  ggagagctg  acggcagag  atggggcca  cagccggcc  4380
ctctcctcc  ctcccggcc  ggactccct  tatgccagc  gggccaacc  gcgggactc  4440
ccctcctac  cggacagca  ccccgaagg  cctaatgag  ccctgcccc  tcccccacc  4500
gctccccct  ggcccccag  aatctacta  acctctcgc  cgccggccc  ggtggctcg  4560
aatccccta  agggctact  ccaggtgcg  cggcccagc  atgagggct  cctggcagc  4620
cccagcctt  aggggccag  gcccgatgg  gatgggcaa  tgcagttgg  cactagtct  4680
tgaggggcc  catggacca  aggcctggc  agggaggga  tccaggagg  gctctggtg  4740
gagcagaga  tgatggagg  agtggctgg  gggccactc  ctccaggtg  ccctctgcc  4800
gtgggcccc  cagtcccct  ggggactat  acctgggcc  caggtgcca  ggttagtag  4860
cagggtttc  accagccac  agccccagc  tctttaggg  agtgcattg  ggagaagcc  4920
ccagggccc  aggagtgag  gagaagctg  taggtgtga  caacgtcca  agctccctc  4980
ctttggagg  agaaagcaa  ggataaggc  tccctaggt  tacaggggt  gccactttt  5040
aggtggccg  agccttgca  gatacaccc  atctgctgc  cactcttct  cgtccacca  5100
aaaggagca  tgggacaga  ggacagggt  cttccatgc  acagttcct  gcttcttgg  5160
gactgggcc  tacatcctg  gagagccca  gcccagggg  tggatgggg  tgtgagggc  5220
ggtggttaa  ggtggaact  tctctgaag  tcctttctc  cttgctatt  gtccctatc  5280
cccgagcaa  cctacccta  acccccaga  tgcacccaa  gaccccctc  cttggggtg  5340
ctcctgatg  agcacaact  cccgcaggg  cccaaccca  tgcagtggc  atatttggg  5400
agttcccag  cctgtgggc  gggctatct  gggagcaga  gtggggtct  gggctccct  5460
aggagtggg  cctgggttt  gatctttcc  tagggggtc  tcttaccct  ctcttcctc  5520
cctattgct  taaatattt  aacaaaatg  aaaaaaaaa  aaaa  5564



<210> 1149
<211> 1515
<212> PRT
<213> Rattus norvegicus
<308> AAC62650
<400> 1149

Met Ala Arg Leu Ala Ala Ala Leu Trp Ser Leu Cys Val Thr Thr Val 
  1               5                  10                  15
Leu Val Thr Ser Ala Thr Gln Gly Leu Ser Arg Ala Gly Leu Pro Phe 
             20                  25                  30
Gly Leu Met Arg Arg Glu Leu Ala Cys Glu Gly Tyr Pro Ile Glu Leu 
         35                  40                  45
Arg Cys Pro Gly Ser Asp Val Ile Met Val Glu Asn Ala Asn Tyr Gly 
     50                  55                  60
Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu Asn 
 65                  70                  75                  80
Val Gln Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Ser Gln Arg Cys 
                 85                  90                  95
Asn Asn Arg Thr Gln Cys Val Val Val Ala Gly Ser Asp Ala Phe Pro 
             100                105                110
Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Asp Cys 
         115                120                125
Val Pro Tyr Lys Val Glu Gln Lys Val Phe Val Cys Pro Gly Thr Leu 
     130                135                140
Gln Lys Val Leu Glu Pro Thr Ser Thr His Glu Ser Glu His Gln Ser 
 145                150                155                160
Gly Ala Trp Cys Lys Asp Pro Leu Gln Ala Gly Asp Arg Ile Tyr Val 
                 165                170                175
Met Pro Trp Ile Pro Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ala Ser 
             180                185                190
Trp Glu Asp Tyr Val Ala Ala Arg His Thr Thr Thr Tyr Arg Leu Pro 
         195                200                205
Asn Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe 
     210                215                220
Tyr Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Tyr Asp Leu Arg Thr 
 225                230                235                240
Arg Ile Lys Ser Gly Glu Thr Val Ile Asn Thr Ala Asn Tyr His Asp 
                 245                250                255
Thr Ser Pro Tyr Arg Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val 
             260                265                270
Asp Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gly Asn Asn Gly 
         275                280                285
Arg Leu Val Val Ser Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Gly 
     290                295                300
Thr Trp Glu Thr Gly Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met 
 305                310                315                320
Val Cys Gly Val Leu Tyr Val Leu Arg Ser Val Tyr Val Asp Asp Asp 
                 325                330                335
Ser Glu Ala Ala Gly Asn Arg Val Asp Tyr Ala Phe Asn Thr Asn Ala 
             340                345                350
Asn Arg Glu Glu Pro Val Ser Leu Ala Phe Pro Asn Pro Tyr Gln Phe 
         355                360                365
Val Ser Ser Val Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp 
     370                375                380
Asn Asn Tyr Phe Val Val Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp 
 385                390                395                400
Pro Ser Ala Gly Pro Ala Thr Ser Pro Pro Leu Ser Thr Thr Thr Thr 
                 405                410                415
Ala Arg Pro Thr Pro Leu Thr Ser Thr Ala Ser Pro Ala Ala Thr Thr 
             420                425                430
Pro Leu Arg Arg Ala Pro Leu Thr Thr His Pro Val Gly Ala Ile Asn 
         435                440                445
Gln Leu Gly Pro Asp Leu Pro Pro Ala Thr Ala Pro Ala Pro Ser Thr 
     450                455                460
Arg Arg Pro Pro Ala Pro Asn Leu His Val Ser Pro Glu Leu Phe Cys 
 465                470                475                480
Glu Pro Arg Glu Val Arg Arg Val Gln Trp Pro Ala Thr Gln Gln Gly 
                 485                490                495
Met Leu Val Glu Arg Pro Cys Pro Lys Gly Thr Arg Gly Ile Ala Ser 
             500                505                510
Phe Gln Cys Leu Pro Ala Leu Gly Leu Trp Asn Pro Arg Gly Pro Asp 
         515                520                525
Leu Ser Asn Cys Thr Ser Pro Trp Val Asn Gln Val Ala Gln Lys Ile 
     530                535                540
Lys Ser Gly Glu Asn Ala Ala Asn Ile Ala Ser Glu Leu Ala Arg His 
 545                550                555                560
Thr Arg Gly Ser Ile Tyr Ala Gly Asp Val Ser Ser Ser Val Lys Leu 
                 565                570                575
Met Glu Gln Leu Leu Asp Ile Leu Asp Ala Gln Leu Gln Ala Leu Arg 
             580                585                590
Pro Ile Glu Arg Glu Ser Ala Gly Lys Asn Tyr Asn Lys Met His Lys 
         595                600                605
Arg Glu Arg Thr Cys Lys Asp Tyr Ile Lys Ala Val Val Glu Thr Val 
     610                615                620
Asp Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys Asp Met Asn 
 625                630                635                640
Ala Thr Glu Gln Val His Thr Ala Thr Met Leu Leu Asp Val Leu Glu 
                 645                650                655
Glu Gly Ala Phe Leu Leu Ala Asp Asn Val Arg Glu Pro Ala Arg Phe 
             660                665                670
Leu Ala Ala Lys Gln Asn Val Val Leu Glu Val Thr Val Leu Ser Thr 
         675                680                685
Glu Gly Gln Val Gln Glu Leu Val Phe Pro Gln Glu Tyr Ala Ser Glu 
     690                695                700
Ser Ser Ile Gln Leu Ser Ala Asn Thr Ile Lys Gln Asn Ser Arg Asn 
 705                710                715                720
Gly Val Val Lys Val Val Phe Ile Leu Tyr Asn Asn Leu Gly Leu Phe 
                 725                730                735
Leu Ser Thr Glu Asn Ala Thr Val Lys Leu Ala Gly Glu Ala Gly Thr 
             740                745                750
Gly Gly Pro Gly Gly Ala Ser Leu Val Val Asn Ser Gln Val Ile Ala 
         755                760                765
Ala Ser Ile Asn Lys Glu Ser Ser Arg Val Phe Leu Met Asp Pro Val 
     770                775                780
Ile Phe Thr Val Ala His Leu Glu Ala Lys Asn His Phe Asn Ala Asn 
 785                790                795                800
Cys Ser Phe Trp Asn Tyr Ser Glu Arg Ser Met Leu Gly Tyr Trp Ser 
                 805                810                815
Thr Gln Gly Cys Arg Leu Val Glu Ser Asn Lys Thr His Thr Thr Cys 
             820                825                830
Ala Cys Ser His Leu Thr Asn Phe Ala Val Leu Met Ala His Arg Glu 
         835                840                845
Ile Tyr Gln Gly Arg Ile Asn Glu Leu Leu Leu Ser Val Ile Thr Trp 
     850                855                860
Val Gly Ile Val Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Ser Thr 
 865                870                875                880
Phe Cys Phe Leu Arg Gly Leu Gln Thr Asp Arg Asn Thr Ile His Lys 
                 885                890                895
Asn Leu Cys Ile Asn Leu Phe Leu Ala Glu Leu Leu Phe Leu Val Gly 
             900                905                910
Ile Asp Lys Thr Gln Tyr Glu Val Ala Cys Pro Ile Phe Ala Gly Leu 
         915                920                925
Leu His Tyr Phe Phe Leu Ala Ala Phe Ser Trp Leu Cys Leu Glu Gly 
     930                935                940
Val His Leu Tyr Leu Leu Leu Val Glu Val Phe Glu Ser Glu Tyr Ser 
 945                950                955                960
Arg Thr Lys Tyr Tyr Tyr Leu Gly Gly Tyr Cys Phe Pro Ala Leu Val 
                 965                970                975
Val Gly Ile Ala Ala Ala Ile Asp Tyr Arg Ser Tyr Gly Thr Glu Lys 
             980                985                990
Ala Cys Trp Leu Arg Val Asp Asn Tyr Phe Ile Trp Ser Phe Ile Gly 
         995                1000                1005
Pro Val Ser Phe Val Ile Val Val Asn Leu Val Phe Leu Met Val Thr 
     1010                1015                1020
Leu His Lys Met Ile Arg Ser Ser Ser Val Leu Lys Pro Asp Ser Ser 
 1025                1030                1035                1040
Arg Leu Asp Asn Ile Lys Ser Trp Ala Leu Gly Ala Ile Ala Leu Leu 
                 1045                1050                1055
Phe Leu Leu Gly Leu Thr Trp Ala Phe Gly Leu Leu Phe Ile Asn Lys 
             1060                1065                1070
Glu Ser Val Val Met Ala Tyr Leu Phe Thr Thr Phe Asn Ala Phe Gln 
         1075                1080                1085
Gly Val Phe Ile Phe Val Phe His Cys Ala Leu Gln Lys Lys Val His 
     1090                1095                1100
Lys Glu Tyr Ser Lys Cys Leu Arg His Ser Tyr Cys Cys Ile Arg Ser 
 1105                1110                1115                1120
Pro Pro Gly Gly Ala His Gly Ser Leu Lys Thr Ser Ala Met Arg Ser 
                 1125                1130                1135
Asn Thr Arg Tyr Tyr Thr Gly Thr Gln Val Pro Gly Gln Gly Arg His 
             1140                1145                1150
Ile His Gln Val Ser Leu Gly Pro Arg Gly Arg Ser Ala Leu Pro Glu 
         1155                1160                1165
Ser Gln Lys Asp Pro Gly Gly Gln Ser Gly Pro Gly Asp Pro Leu Thr 
     1170                1175                1180
Phe Gly Leu Cys Pro Ser Arg Ile Arg Arg Met Trp Asn Asp Thr Val 
 1185                1190                1195                1200
Arg Lys Gln Thr Glu Ser Ser Phe Met Ala Gly Asp Ile Asn Ser Thr 
                 1205                1210                1215
Pro Thr Leu Asn Arg Gly Thr Met Gly Asn His Leu Leu Thr Asn Pro 
             1220                1225                1230
Val Leu Gln Pro Arg Gly Gly Thr Ser Pro Tyr Asn Thr Leu Ile Ala 
         1235                1240                1245
Glu Ser Val Gly Phe Asn Pro Ser Ser Pro Pro Val Phe Asn Ser Pro 
     1250                1255                1260
Gly Ser Tyr Arg Glu Pro Lys His Pro Leu Gly Gly Arg Glu Ala Cys 
 1265                1270                1275                1280
Gly Met Asp Thr Leu Pro Leu Asn Gly Asn Phe Asn Asn Ser Tyr Ser 
                 1285                1290                1295
Leu Arg Ser Gly Asp Phe Pro Pro Gly Asp Gly Gly Pro Glu Pro Pro 
             1300                1305                1310
Arg Gly Arg Asn Leu Ala Asp Ala Ala Ala Phe Glu Lys Met Ile Ile 
         1315                1320                1325
Ser Glu Leu Val His Asn Asn Leu Arg Gly Ala Ser Gly Gly Ala Lys 
     1330                1335                1340
Gly Pro Pro Pro Glu Pro Pro Val Pro Pro Val Pro Gly Val Ser Glu 
 1345                1350                1355                1360
Asp Glu Ala Gly Gly Pro Gly Gly Ala Asp Arg Ala Glu Ile Glu Leu 
                 1365                1370                1375
Leu Tyr Lys Ala Leu Glu Glu Pro Leu Leu Leu Pro Arg Ala Gln Ser 
             1380                1385                1390
Val Leu Tyr Gln Ser Asp Leu Asp Glu Ser Glu Ser Cys Thr Ala Glu 
         1395                1400                1405
Asp Gly Ala Thr Ser Arg Pro Leu Ser Ser Pro Pro Gly Arg Asp Ser 
     1410                1415                1420
Leu Tyr Ala Ser Gly Ala Asn Leu Arg Asp Ser Pro Ser Tyr Pro Asp 
 1425                1430                1435                1440
Ser Ser Pro Glu Gly Pro Asn Glu Ala Leu Pro Pro Pro Pro Pro Ala 
                 1445                1450                1455
Pro Pro Gly Pro Pro Glu Ile Tyr Tyr Thr Ser Arg Pro Pro Ala Leu 
             1460                1465                1470
Val Ala Arg Asn Pro Leu Gln Gly Tyr Tyr Gln Val Arg Arg Pro Ser 
         1475                1480                1485
His Glu Gly Tyr Leu Ala Ala Pro Ser Leu Glu Gly Pro Gly Pro Asp 
     1490                1495                1500
Gly Asp Gly Gln Met Gln Leu Val Thr Ser Leu 
 1505                1510                1515



<210> 1150
<211> 31737
<212> DNA
<213> Homo sapiens
<308> AL157903
<400> 1150

gatcttttc  cactcataa  ctttcaaaa  cacaaaatc  tgatttgtt  tggttgggt  60
gctactcca  cattctttc  tcacattct  ccgtggcat  gaaaacttg  catttcagt  120
ttcatggct  cctttggaa  caacttaat  atgtgaaat  gtcatgtag  tttaagccc  180
tctgaagat  ataggtcaa  ctgaaaatt  aaggggacc  ttgctttat  gtgtcagtt  240
taccttttg  aaccttggc  gaatattga  taaacattt  accaataag  ttcagattg  300
tttacatat  gtgtaaaat  tatcaaaag  aacagtcaa  atctgatgg  attatgaag  360
tgatgggat  atgaaggta  ctagaggta  ctgcctctt  tcctcttaa  gaaattagt  420
ataaattaa  ttgttactg  aacttaaaa  caagataaa  ctgaaagtg  atccttgag  480
ttttctgaa  tgtttctcc  cttgctttc  tcctgatct  agttttctt  ctttctgtc  540
gtcttgtct  gtcttgttt  tcttgtctt  tcctgtcct  tcctgtcct  tcctgtcct  600
tcgtgtctt  cctcttcgc  tctcttctc  tctcttttt  ttttttttt  tgagatgga  660
tcttgctct  taccccagg  tagagtaca  tggcaccat  tcagcttac  gcaacctct  720
cctcctggg  tcaagtgat  ctcctgctt  agcctctct  gtagctgtg  ttataggca  780
acaccactg  gcccggcta  tttttgcat  tttattaga  attggggtc  caccacatt  840
gccaggctg  tctcaaact  ctggtctta  gtgatccac  cacctcagc  tcccaatgt  900
ctgggatta  tggtatgag  catcgaacc  gaccttctt  tttaagttt  aatttgctt  960
tgctgccag  ggaaaaatg  ctggattgc  tgtgtctta  actcttaac  tctataggc  1020
gcacactct  tctccccaa  atccctgca  caagtgacc  tgtcaaaca  aagtgtgga  1080
taatgggag  cagcccagt  atggtgggt  gtttataag  agctgtttg  tactgtcag  1140
acaaaggca  atcagagtt  cattaaagg  atatgacag  gtgaacaac  gctggccca  1200
ttccctaat  atacttgtc  tctagtgtt  gattgaaaa  tgagtggct  gagtagtta  1260
tcgtatggg  ttgggatga  aaatatata  gaaaataaa  atctatttc  gtcatttaa  1320
aaaatacag  atttaggaa  caaaatttg  ttaaagcag  tttataatg  ttttgagtg  1380
cagaaacat  atgagtatg  tatgttcta  tacattgtt  atagcattg  tcattgtta  1440
ataggattt  taactgtga  atatttgaa  ctgtttaat  ttgcaccat  ttgtgacca  1500
attcttgat  tacttgtgt  aatttggaa  aacaattaa  tcttactct  taaaatact  1560
gttaagtgt  gcactcttc  tacatgtcc  taatggaaa  acacttgcc  tttatttgt  1620
gcttgatat  tagtctgtc  ttttgttat  gtttttgga  ggggcttag  gtttatgtg  1680
gacttaggt  ctgctgtga  atggagagc  tcacctata  ctggcattt  catttttgt  1740
atattgttt  caaaatgtt  cagagaggt  cattttctt  caccccgtc  ctctaatgc  1800
cagttaaca  tatgtcctt  acttgaact  tctcccttg  aaatcaatt  tgcatttgc  1860
atagtagtt  agcttttta  agtgcataa  gagaatact  tataaaaag  gcttgtaaa  1920
caagtcttt  tctaagagt  tagaccttg  gaattatgt  tttgttttt  aataaatgg  1980
taaggtatt  taaaaagtt  gacatttta  cagagttac  atatttgag  taattttta  2040
aatattttt  aaagagtta  gttatagtg  tttccacgc  agactttat  tgaaataaa  2100
acattaaga  tgtagagtt  ttgatgcct  gtcaaaagt  gaattaagg  tggttttat  2160
atatgcttt  aatgtgttt  tgaaatatt  tttgaagcg  atacttgta  gttaaatac  2220
ttttatcat  tatttttat  ataatttta  atatactct  tcagggaat  atatttaag  2280
atcccaaca  ttgttttta  ggtatatct  tacattgta  tctgtagta  tttaatttc  2340
tataaacct  ttaataata  tagacaata  gtgaccttt  acactcatt  atatgtgct  2400
taaaattac  ttttccttt  attctatta  atcctttca  accactaga  aaatccctg  2460
tttgtactt  acagaggtt  tcatgtatt  acaagtaga  ttacctggc  atcaataag  2520
acttgttta  ctagagtga  taagttaaa  acttgtaga  gttaggact  tctgaagct  2580
ataatccaa  accctaatt  gtgactcga  ggatcagat  cacagtagt  caagacttg  2640
tgtttttgt  cagggtaag  tagtaattt  gtgacagaa  ccagataac  caaatcctc  2700
gactagaga  aaattatta  gatttcttg  catttattg  tattcccta  ctttagctt  2760
tacacagct  aatctactt  tggaagttc  gcttcaaaa  gttttagcc  tagtttcaa  2820
gctgttgac  gtggttgag  tttattaac  accttggtt  tctaatgta  tggaattca  2880
agtagatca  attccttcc  tgagccagg  ttctctgag  gctcttctt  accactcct  2940
cccaaccgc  cattctaca  tattgagcc  taactcctg  tcctgtctc  tggccatcc  3000
ttttaatag  tttgtatta  attgtccat  atcaacaac  ttttgtttt  atagatatt  3060
tcacttcaa  gtggcataa  atagtatat  tttctcagg  ttgactttc  caattaaga  3120
tatttgcct  catctctgt  cattaaaat  tattgctgc  attgacatg  ctaaggtgg  3180
ataacagtg  tgtgagcat  atctagagc  agtctgaat  agtctgaat  atagctctt  3240
tgttcatga  cttgggcca  ttacccttt  tgtgctttg  tttacatat  tttaaaatg  3300
ggattaaaa  attactatt  ggattaaag  aattataat  ttattcata  agtactgag  3360
atcttgcct  atatatata  taagatgct  catcagtgt  aaatcatag  aggagccag  3420
aaattgttt  agtatttta  tgtgtgtac  tgaggttct  gagatattc  aagaacaac  3480
cacattcct  gtttgacct  aatgaacca  gaatattta  atacatagc  tttattttt  3540
gagccacat  ttactgaaa  taaacctag  aacaatacg  ggctttttt  ggggagggg  3600
gaggttgtt  tttgcttta  gaaccttgc  ttgttaaaa  aaaagccta  cttgccttt  3660
tgggaaggc  agttagacg  agaccttaa  agaaatcta  ctactgcca  ttataggtg  3720
ttatatgga  accttacct  tagaagtta  tgagtgtga  ttatctgct  aatagcgat  3780
aaatccgtt  aaaatgttt  ccaggtgtt  atcataagt  aaggttgac  tagccagtt  3840
aatcttatt  gaaagaaag  aaaatctct  taaatcatg  ttacagatt  tttaaaaac  3900
ggctggcaa  gtttattat  aaaatccat  attttccat  tgtttgcta  attagaata  3960
tatgcagtt  taatgaata  acatttata  tttctgctc  taaaaattg  actacagtt  4020
cgtgagttt  gtctcatct  gtaagcttt  caagagatt  agggaagcc  tagctttcc  4080
agtatgcaa  tctcttaca  tcaaagcac  tccctcagg  acaagaaga  tatttcagt  4140
gcatgcttt  ctcttttcc  ttaacatat  taacatgag  aacatagat  ggggacagc  4200
tatctatgt  tgaatagat  ttgaagaaa  tatatgaga  gaattgata  aaagtttta  4260
ttttaattg  ttgctttgt  atatattta  ttggtgact  taaaaagta  atttcagaa  4320
atttattta  actatcaat  catgtttta  aattattcg  ttgagttgt  aataattaa  4380
gaaaaaggc  ttttatgtg  cactgaatc  acctgttag  ttcagttgt  caccctgga  4440
ttctttcat  taatcgtct  cttcttact  caaaggagg  catttattc  ttactttgc  4500
caaataata  taacacact  gcagatggt  actttccaa  tggtttgtc  tcagaaaag  4560
aattaaaat  ttatagtgc  agagagaga  gttgtaatg  gtccctttc  aattaacag  4620
tcattcttt  caactattt  gtaactgta  aatagctca  tgtcacata  aaggctaaa  4680
gctagagta  atggtgtca  gggaaacat  aaataaaca  agtgtaatg  tttatagtc  4740
tgtcttgaa  acactaaga  tatttcttt  ctaaaaaga  acaaattat  tgctacggt  4800
gtattttgg  tttactgga  tctagttta  ttagttcat  tcaaaagtt  gcacttgtt  4860
taaaacgtg  atacattct  aaagaagat  cttccccca  aacatttaa  aataccttg  4920
atatattct  aaacaaata  gttagccta  caaacaatg  aatgaaaac  aaatatgaa  4980
ataatgtat  ttcttcctt  accccttca  tgaatgatc  gtaactctg  taaaaagat  5040
agtttagag  ttattgaat  attttaata  taggaccag  ctgaaagta  cattgtgca  5100
ttagaaatg  aacatataa  tgagtagaa  tggagcccc  catgattgg  aaataagct  5160
gagaaactg  agtatgctt  aaacacaga  taattagcg  gcaagctca  gaaaaaaaa  5220
atctcagaa  acttagaag  agtgtttga  gaactagaa  catcacagt  taaattatt  5280
gttttgacc  ttctctgcc  ctgaattgc  gtgtatctt  gggcagtca  ttagatcat  5340
tccttgact  gaacagtag  aagttggct  agacaactc  taagccctt  ttttaaagt  5400
ttatagcta  ttggttggt  atgaattac  taacccaga  tttaaaaaa  aaaaaaaca  5460
cttaaaatg  atttgccta  gtgagccag  tagatttat  atgagaaag  aagaagttt  5520
tataatatt  tttattctt  ttctgaaaa  aatcaagtg  taatagaaa  ccaaataca  5580
aataactga  ttcgatttg  attcctcct  attactagc  ctgtgaaca  aaacaggtc  5640
tttaaatat  ttgtatggg  ttggtgcag  ggctcacac  tgtaatcct  gcactttgg  5700
aggccgagg  gggctgatc  cttgaggcc  ggagtcctg  ggccaggag  ttgagacca  5760
cctggccaa  gtggtgaaa  cctgtctct  ttaaaatta  aaaaattag  cgggcttgt  5820
ggcacgcac  tgtaatccc  gctactcag  tggctgagg  atgagaatc  cttgaatcc  5880
ggaggtgga  gttgcagtg  gccaagatc  tgtcactgt  ctccaatct  ggcgataga  5940
tgagacatt  tatctaaat  aataaataa  taagttgta  tttggatcc  caataaata  6000
gttgtattt  ggatcctca  ccgaacaat  gaaattata  tttttctgg  tatctcact  6060
tgtctaaag  gatgtccta  tgtgttgcc  ttttcaaag  gtgatcatt  gactattcc  6120
ataagagcc  ttattggaa  gctttctag  atattattt  cctcagata  tccatctgt  6180
tggggagtt  tttctcaaa  agttggaca  tttctgtct  tttaagggt  aaatatatg  6240
gacagcctt  tctaatttg  acagagatg  aaaattaag  cagccttaa  ttctttctt  6300
actgagagt  tttcttaga  agtaatttt  agatattga  gcaggttat  ttcctcctt  6360
gcttaacaa  gttcaggtt  ttgtctcag  accaggaag  agtaggcat  cggacactt  6420
aagagtgag  ggtgtagat  ttattaagc  aaaggaaag  tctcagcaa  gagaggggt  6480
ctgaaacca  gttgccggg  tctcccttt  cagttgaat  cgagggctt  tatatctgc  6540
tgatggggc  gggttttct  tttgtataa  gcatgaatt  cttctccct  ccaccgccc  6600
ccgccccat  ccgtccagt  cacacgcgg  cccttagtc  gagccattc  acattgatt  6660
atttccctt  ctgtgcatg  gttaaggga  agaattttt  accacgggc  tgtttaggc  6720
agccccctg  gcacaatga  attggtggg  tggatgttg  cctgggacc  ttccctatc  6780
gcctaggca  ttggctgtc  cctgcctct  tcaatatct  tttgtcctt  cctctcaaa  6840
ccctacttt  accagcgaa  tggaatatt  gtcttaaac  ttgtggtgt  attactcat  6900
ccaccccat  tcttcctat  tttgtttga  atgccagta  actcatatt  cataatata  6960
gataaacag  tttatatgt  gaagtgtga  attatatat  gttatgaat  gtaggggaa  7020
tggtagatc  gggactcaa  atgattgct  gaactttat  tatatatat  tttggtaag  7080
cattaattc  ctgagtact  caaatattt  attttattt  tgagacgga  tcttgctct  7140
tcacccagg  tggagtgca  tggcgcgat  ttggctcac  gcaagctcc  cctcccggg  7200
tcacgccat  ctcctgcct  agcctcccg  gtagctgag  ctacaggag  ccgccgcca  7260
gcccggcta  ttttttgta  tttttagta  aaacggggt  tcaccatgt  agccaggat  7320
gtctcgatc  cctgacctc  tgatccacc  gcctcggca  cccaaagtg  tgggattac  7380
ggcgtgagc  accaagcct  gtcgtactt  aaatattag  cccatgttc  tgtttgaaa  7440
tgtttaatc  aaagttgtt  caaatagta  tgaaaaagg  aagaaacct  cccttgtga  7500
tgttcttgc  catggttat  ctctctgtt  tgtctgttc  tcctgccag  gtaagctga  7560
atctccctt  ctccataat  tattttaca  ctccagttc  cattagtct  tactctgag  7620
tcctacacc  cttacagta  gcaccacat  attgagtat  tacttatat  tccttccgt  7680
tatggattg  tgatgtttc  tctgtttct  tgcttcccc  gtagacctc  gactataca  7740
ggtgaagac  atattttgt  taatctttc  ctaaatgtt  ctaagaatg  gttagagca  7800
ctaagtggt  ctcagtgaa  actagattg  tttgttttt  tccttttct  catttcctt  7860
cactgagtg  gaaaattgc  agaaatcac  caccatccc  ccttttttt  ctgagtcta  7920
ctttttaat  ggcctctct  ctttcctgg  atgccaaga  agatgtact  caaaagtct  7980
tatatagaa  ttgtacaat  tgtttcttg  ttttaagta  atgaagaaa  acgtggaca  8040
agagaaatg  tgattcata  tatgttcta  ttagaaatg  gaaagttgg  taaacatta  8100
aaaatcagc  tggtgttac  gatgtgttt  ttttccctt  cttaattgt  tgaagtttg  8160
agaatttac  gttttctac  gtaactaag  gatatgctt  ctggcagac  tattgaaga  8220
tttggttta  gccaaatat  ctactaata  tttaaatgt  ccacatagt  aggatcttt  8280
ggtattcat  agagtaaaa  ttaatttta  cttaaaaac  agagtaaaa  acctttttt  8340
aaacagtaa  aaatctgct  tctgcaaac  gtgtccaga  aaccagagc  gtttagctg  8400
ataatgaaa  agtaaatgt  aaagcaatt  gaagaacat  cacattaac  ttatggtta  8460
aagagtgag  gatggaatg  cttttgtat  catgacata  ttcaaacag  aaaatatgc  8520
atctgtttt  atagttcat  agatgctcc  caatcccct  tcaaccagt  ctggtagat  8580
attaagacc  aacacattt  ttgtatgta  tgaataatt  ctctaatgc  tctagaatt  8640
aacagaatt  ggaaatagc  ctcaaataa  tttatgtgg  gctttattt  cttgtggaa  8700
cctagttga  aaaggctat  caatctctt  taacctcta  ttgaacaga  tcttatttt  8760
tcacgtata  gtttgaaga  cttaaccct  ctagattat  tttacttga  ccaattact  8820
agtggttaa  aatgtattg  ctatacaat  cagtccaaa  ctggttggc  ctatttgtt  8880
tctaaagtt  taaatgtag  tatgtttta  tgacagcat  tttgctact  aattatgtc  8940
tttcttgac  gctcaaact  tctctgttt  ctcttattt  gaatgcagc  ggcaacagc  9000
gttggtttg  gaaacccag  catataatt  acttcccca  ttaaggtat  gtttgtttc  9060
ttggaagag  aagaatttt  ggggtatgt  tctttagtc  gagaagtaa  gcagtttat  9120
ttcagtatg  tatatttta  gtgacagaa  ataagcaga  aatttttta  aaaattata  9180
cattctaac  ttacttgag  actaaagtg  tacaaaaaa  actttgtta  tatttgaac  9240
acgaaaatc  gatattagc  ttcagcgta  atgtcaaat  aacacaggc  agtaggaac  9300
tttgtgatc  tgttcttct  acatctact  gcatggata  tgaagcttt  actattgct  9360
tgatgtaga  ttttggagg  aatcctcct  ctatttcca  gacactttg  agttactaa  9420
tctaagaga  tataagcga  tccatttat  taaaataaa  taaaaatgg  gggaaagat  9480
tttaagcaa  aaatttcat  ccatgagat  ttttatatc  tggttactt  aaaacccag  9540
aagctgccc  gggttctct  ctgatactg  acagaactt  tgttttaca  cctcgtctt  9600
ctattatta  ttcaactat  ttgtttttc  ctttccagc  ctctatctg  atttttgta  9660
ttattactg  cttcctatt  ctagttcaa  tatattgtt  ttctctttc  agcactcta  9720
ctggatttt  gtaattatt  ctgtcttcc  ttatcagtt  taaaagtta  gatatgtgg  9780
atttttgag  tcagaattg  agccattat  ttgatgtgc  gcagatatt  agagaaaaa  9840
tccttagtt  ccagctttt  gtatactca  gtgttatgg  ttcttaaga  taaatgttt  9900
tttgttttc  tatgaaatt  tcttttttt  ttttttagg  tacatgtct  actttgtca  9960
ccagtctag  gtgcagtgg  ttggttccc  tcagccttg  tctcctggg  tcaagtgat  10020
ctcccccct  agcccccag  atagccggg  ctttaggca  gtgcgacaa  tcccaacta  10080
cttttgtac  ttttgtaga  acggggttt  gccacatta  ccaggctgg  cttgaactc  10140
tgagctcaa  ctttgtaat  ccaaagtac  ggaattaca  gcacgagcc  ccgcgccca  10200
cccaaactg  cttcctttt  gcccagccc  tgagaacaa  ctgtgctag  gaatgattt  10260
taaagaatc  tgctacttt  ttctgcctg  gattatgtg  tgactgaat  tagtttcct  10320
agagatact  ttgattttt  taaactaaa  gtctaccag  ctttctgct  tgttgttcc  10380
aaattggac  atttcctgc  tggtatttt  tttttaagt  gaaaatggg  aaattgcta  10440
tgatgttga  agcaaaaat  gtattgaat  ctttctgac  aaacatata  tgaacaaag  10500
aaaacacta  gtatctgct  tttcatata  cattcggaa  ctcttgtga  ataatcagg  10560
ctattttct  tataagatg  ggaggtagg  ttataaata  gctacgtaa  tgaccagct  10620
tagaggaac  tgatacgaa  gtgacccca  actgagttt  agtaaataa  acagaaata  10680
tgaatatat  gaatcatga  ccttcctgc  gatgaagaa  atcattttg  tttttgata  10740
agagtgata  aatgaaaac  atattggta  tattgctta  attatatag  agttgaagt  10800
agtagagat  aattcataa  tgagtgatc  gtaaaagag  gttccagaa  aacatatgg  10860
aaaatgaac  gaaggagga  ttttgaaaa  aaatagaat  atgttggaa  acaagtgtc  10920
ttaatggat  agttaagga  gtaaaaata  ttaatataa  gcaagggaa  cagtgtatg  10980
agttagaga  ataaaattg  caatttatt  attgatttt  ttttataat  gttattatt  11040
gaaaaacga  caatacgaa  aaatagaag  aaggagggg  aagtgaagg  aaactgttt  11100
tagctggta  catctattt  gcaatgtct  tactgttat  cttataata  ttgatttat  11160
aatgttaac  gtaacatat  catgtaaat  tttgtgttt  ttttatata  gactctttt  11220
acctgatgt  tcatctcta  tttcagagg  atttaaaaa  aatgtttaa  tttagacat  11280
agcgattac  ggttcagaa  caagtcttc  aatgataaa  taattcatt  gtaaaaact  11340
cccataaac  cagctgcta  ggcctgcca  attggcacc  tggttccac  tcttatcca  11400
ggcttgaca  gaatatact  ctgcttact  agttaatta  tgctcacag  tagaaaagg  11460
aaggccttt  attcagcat  tgtatcgtc  catggccct  ttcagtcaa  ctgagtgca  11520
gttacatga  tgcctgaga  gaacagaaa  gctagtttc  cagtctcta  ccagaatgc  11580
tgataaggc  tggtgtcaa  aagggcaag  tggggatca  agcaattat  gcagaggca  11640
agtagttac  ttgacaacc  gattgagga  tcattgcga  ttattattt  ctacttgaa  11700
atctcactc  gatttaatt  agggttgag  tttccatga  gtctgtctt  tctaaattt  11760
agcaccctg  tactgttgt  tatgtgtgc  ctgaaataa  ctcaaactg  tgttactcc  11820
aaactgtga  gaattaggc  taacatgta  ttttttgaa  atttagaca  gtcagataa  11880
agttaactg  aattaactg  atcttatat  gggcgatgg  aatcaatgc  tactagtaa  11940
ttagtaaca  tgactccct  ggtatcttc  aagcagcct  gttgtaata  gtgaatttt  12000
tcttttttg  tgaaagcag  tttaaataa  ttatacctg  tttgtattt  agtgtatca  12060
tttagatat  cacgttatt  ctttgcagt  acttaatgg  acacttttt  gggtgggga  12120
acaaagtct  gcttttgtc  ccaggctgg  gtgcagtgg  gcgatctca  ctcactgca  12180
tctctgcct  ccaggttca  gcgattccc  tgcctcagc  tcccaagta  ctgggacta  12240
aggcatgca  caccacacc  ggctaattt  ttgtgtttt  gtagagaca  ggtttcacc  12300
tgttggcca  gaaagtttc  atctcctga  ctcgtgatc  gcccgtctc  gcttcccaa  12360
gtgctggga  tacaggcat  agccaccat  cccagctgg  acacctttt  tattgccca  12420
attatagtc  ataaaatgt  attgtaatc  gataattct  ggccagaaa  cgaaagttc  12480
ccttcttag  gtgagttaa  cattaggta  ttttgtatt  tatgttttt  tcttcccaa  12540
tattcctga  atgcttttt  cctttgcag  tgtaactca  ttgactact  attcagcat  12600
aattaataa  aaaatatga  aggcttttc  acctatgat  tttatttaa  caaaacctt  12660
caaataaaa  taattttaa  cctgtattt  atttctatt  aaaatggag  gttttcata  12720
actctttta  attaaaata  tgtctgctt  gctcgttta  attctttct  tcagaatgt  12780
tgcctcagg  ttctatata  aattaatgt  agaaaaaca  gagggtaat  ccttggtag  12840
aaactggta  tggattaaa  gaccatagc  ctgaaattc  agtaatgtg  cacattttc  12900
ctgaaagat  cacttaggc  cgatatcta  agatattaa  aagtgcccc  tattttaat  12960
agctaaaga  agacattcc  aatatattt  gttgtatgt  taatatgga  tattataag  13020
aaattcata  actgatact  aatacgatt  gagaagaat  actgctttg  tgagaagag  13080
gctttgagt  tcacttgaa  cttcaaatt  cttactgaa  caattgata  aatgtacaa  13140
atgtgtatt  agaatgtgc  gaacagcca  ccaggtagt  tgatcagtg  ctttctaca  13200
agtgcctaa  atgaactag  ttaagaaac  tgaggaatc  acataacta  ccttggttc  13260
aatttttta  ttaaaaagt  tagactaga  cagtgcttt  caaattgtg  tttccaacc  13320
attatcagt  tgtaagcac  gtatttagt  ggttacaat  atcacttat  aaagagagc  13380
aatatcaga  cacagttta  ataatgagt  ttatttcat  aaatttgca  taattatat  13440
ttcatatct  aagggtaca  tgttttgat  taacatgtc  tacttaagg  atgcagtaa  13500
aatatataa  aggaaacac  gggctgcat  atcctaaaa  tctctccca  ttccaacat  13560
cccgagtga  attttaaac  tgtagctct  ccttaagta  cattatatc  ttatgttat  13620
tcaatagaa  ttgtcacat  cagatgcat  ttgggagaa  aagaggaga  aggtgcaag  13680
cttgatatt  tgagagact  atacctata  aaattgtaa  tattcctaa  tgctatgtg  13740
gataattta  gcctgcaca  aattgctga  agcatatca  acaaatgat  agttctcat  13800
gtcaggccc  gaaaatacc  cgtgactaa  attagagta  atcctttaa  gatgagtat  13860
atttcattc  tttgggata  agaattcag  gaaagagtc  ggatacttt  gctgtggct  13920
gacagtcaa  cggccttct  tgccatact  aggcatttg  aatttatct  aaaagacca  13980
ggaaagctg  caaacccat  cagcctgct  ggattagct  tccttttag  acgatgaaa  14040
tagtaatgt  attgttgaa  tcaagtaga  aaaaattca  ggtatggag  caataagtt  14100
caagaattt  agaaggtca  ctataaacg  agaaactcc  cttttgata  agagtgaaa  14160
acaactctt  atcaaaagc  tgacagtgc  catacaaca  acgaattga  tttcacttt  14220
gtattttgg  aatactgga  cagctttca  tacctttgc  aaatgccca  gtaaatgta  14280
gtgaaatgt  gaaagactt  aatgagtcc  gcatatagg  aaaccttgt  ttattgagc  14340
ttgtagata  tgcattgtt  ttttatttt  tttatttat  tttttgaga  ggagtcttg  14400
tctgtaacc  aggctggag  gcagtggtg  aatctcgct  actgcaagc  ctgcctcct  14460
ggttcacgc  attctcccg  ctcagcctc  cgagtagct  ggactacag  cgcccgcca  14520
cgcgcccgg  taattttgt  tttgtattt  tagtagaga  ggggtttca  cttggcacc  14580
tagtagacc  aggatgttc  cgatctcct  acctcgtga  ctgcccccc  tggcctccc  14640
aagtgctgg  attacaagt  tgaaccact  cgcccggcc  gcttttttt  taaattgaa  14700
gtttatgga  accttgttt  ccacaagtc  tatcagcac  atttttcca  cagtatgtg  14760
tcacttcat  tgtctgtgt  acattttgt  aattcccac  atatttcaa  tttttctat  14820
atatctgtt  tggtgatct  taatcagtg  tctttgata  tattataac  atttgatgt  14880
tattattgt  attggagtg  catgaatca  gcccattcc  gacgatgaa  ttaaggaat  14940
ttaggtttt  tgactgctc  accaactgg  ccttccctg  ctctccccc  ctcatcagg  15000
ctccctatt  cctgagaca  aaaaatttt  aaattaacc  attaataat  ctacaacgg  15060
ctatatatg  tcaagtgaa  tgaaaagtt  cacatttct  catattaaa  caaaagata  15120
aaatgatta  gcttagtga  gaaggcata  caaaagctt  gacagaacg  aatctcggc  15180
tcttgtgcc  gttagccaa  tcgtgaatg  aaggaaaaa  ttcttgaag  aaattaaaa  15240
tgctacttc  gtgaacaca  agatgataa  aaagtgaaa  agcttttgt  gcttatatg  15300
agaaagttt  agtggtctg  agagaagat  aaaccagtc  caagattct  ttaagccaa  15360
gcataatcc  gagcaaggc  ccaactgtc  tcaattcta  gaacgctga  aggtgagga  15420
gatgtggag  aaagtttac  gttaccaga  gttagctca  ggggctgaa  gaaagaagc  15480
attgttccc  taacataga  gtgggaggt  aagcagcaa  tgttgatat  gaagctgca  15540
caagttatg  agaagatct  gctaagatc  ttgatggag  tggctacac  aaacaacag  15600
ttttaaata  agacaaaac  gccttctgt  ggaagaaga  gccctctag  ctcttcata  15660
ctgaagaga  gtcagtgtc  ggcttcaga  tttcaaagg  cagactgtc  tgttagggg  15720
taatgcagc  ggtgacttt  agttgaagc  aatattcat  taccatttc  aaaatcctt  15780
ggccattag  aattatgtt  agtctgagg  atacagatg  acccaccct  ctctttgcc  15840
ttttatcaa  actcagtgt  caaggattg  atgtgtggg  cacctcggt  tcctctgct  15900
taatgctcc  catctctgg  aataaatta  ttctctttg  aaaacttaa  atttattaa  15960
gtgaatttt  ggatcttat  cacataatt  atacgagca  taacttgtc  tcctgtctc  16020
gaattgaat  ttttgatag  ttcctgata  agtttatgc  gtgtcttct  ttagaggag  16080
ctttaaaag  agggagctc  tgatcccta  aggagaagc  gagcagata  aagggcatt  16140
caagtgggg  gaatactgt  aagaacgct  caaagacag  aattcacat  ccagatttt  16200
tatagtgaa  atttaagac  caattccat  gtgtaaaca  attaacttt  ttatttaaa  16260
aaattatat  gaaaaaatt  attttggaa  tttctacta  agcagcttg  tgccacagg  16320
accatttgt  tcttttata  aaaatttat  tttggaaaa  cagttcatc  atctacctt  16380
cagcatgtc  aggttaact  aacagccaa  tgccagccg  gggagatac  gggaagaaa  16440
ttggactaa  ttgggggtc  gggagaatt  ggaacaaac  gcaagaagg  aattaagag  16500
tgggagagg  ggggattag  aaaaatgta  gcaatatat  ggaatattt  gcttgagca  16560
aatatctct  attgaatca  tgtgttggg  cacacatca  gcaggggaa  tgtatctta  16620
ctgtgataa  ggaactgtg  tgtagggtg  agagataca  ggcagtctt  gaaaaaact  16680
gcccatctc  atgttcacc  aggtctaca  tctggtagc  ctgaaccag  aagattata  16740
aaatcttga  atcttctct  tggttctca  ggtgagaaa  tgtatattt  tagattgtt  16800
ccacaaagg  gacagaatt  ctgttattc  cctgggccg  gtgcctttt  gttcatcta  16860
tcaccttaa  ccaagtccc  tttcttggt  cctcagggt  ggcagccat  ttcattagc  16920
ctcttatta  tgaacctag  tggtttaga  gaactggtc  ctgttagtc  aaaaagggt  16980
tccagttct  gtttttgtt  tttatttcc  cccatgcat  tatatagaa  tataatttt  17040
gtcttttac  tacttttct  ggaacccat  cccaaatca  taaatatta  tatagtatt  17100
tttctaata  ttattttta  tgtatttat  ttatttaac  ttatattgt  ttttattct  17160
ttacattgt  ttatgatgt  ttgcatcat  ttccatttt  tcaatatag  tttaaaata  17220
ttctttact  tggaccttc  gtttgtctc  acattttta  tcataaatt  tatctaaat  17280
ttagtcaag  tttttggtt  ttgttagag  atgttgttc  tgcaaatgg  atttggtaa  17340
gctcttctc  gaaagactg  accgcctca  aatttcaga  atatatgat  ctgtctgtt  17400
taaaacagc  atacaaaca  atccttggt  atttgatag  agaaaatgt  accatattt  17460
aaatttttg  tgccttttt  tccttgcca  ttaaattga  cattacatg  ttatttcct  17520
cttaaattt  tttcatttt  cctttccat  tcttaccta  tttgaaatt  atactcttt  17580
tttgtaagc  cttttatgt  gagtattta  ccttgagtt  ctcgtttag  cagctgatc  17640
ttttttgct  cactacacg  cttttcaat  tagaatgct  cagtttgag  tagatcgat  17700
tatctgtct  ttggtggtt  ttatttcat  aatccgaat  tattgctat  ttgagatca  17760
atttaccca  attttcttg  tagtattat  gttattcta  cactgaaat  attaacgca  17820
ttatgtttg  aggtctttt  taactagaa  ttagtcctt  gcagaacat  ataagtgtg  17880
ctaataagt  tgtgtgtgt  tgtgtgtgt  tatgtgtgt  tggttttat  tcagagttg  17940
tttatttta  tttatgatg  atttcagtt  ctattagag  agtgctttt  ggttgagat  18000
cattttttt  tccatcaat  tttgtacca  cactgtgaa  taatttaat  tcatgactg  18060
ttttcaaat  aagagattg  ggactgata  ttgaagtga  ttatccaat  tcacagagc  18120
ctttaaggg  tagaacaag  attccaagc  aagtcagtt  actccttgt  cggaattac  18180
tttcactgt  aaatagtta  ccattttag  attaaacac  tcagattta  gtagtttga  18240
ctcaataat  tctgtacag  ttaaattaa  atcttaggg  gaagtaata  ttaagagga  18300
catttaaaa  atgtagtta  tgacctaat  atttcccca  ccaccacac  ccctgtagg  18360
ttttcataa  cagagaatt  tattctaag  ttgtgttct  atttcatta  cactgtgat  18420
agccataag  attgtgttt  actatcttt  atctgttct  ctccatatc  aaacattca  18480
tgacaagag  agattgtag  ctattcact  attttgtcc  aaccagttg  aatagtggt  18540
agcaactgt  ttccataaa  ggctagatg  taaattttt  agactttgt  ggccaaatt  18600
aagggtgtt  tatagatat  tatataatg  gagaaatga  tatccaaca  atttattga  18660
aattttcag  tcttattac  tgacactga  aatttcata  atttttatg  gtcatgaaa  18720
attgttctt  tgattttgt  tgaacatta  aaaatgtaa  tggaccatg  gaacactag  18780
agtccaacc  ttatttaga  gggactgtt  tgggtatct  gtagatcag  tttgaattc  18840
atttgtaaa  catttgagt  tttacttta  aataatatt  aatataaat  aacatcaca  18900
ttttctgag  aaactgaag  tcatttgta  agaaacttc  tcaagtttt  ccaagtcag  18960
aaatggcag  actagaatt  aaaacctta  ctatttttc  gtgcctggg  tctttcatg  19020
gttcattgt  acatcttct  tgccaggca  ggagatagg  acagtgcat  ctggcatga  19080
ttagatgag  tcctgcttc  acatagtcc  tagtcatga  gctgcacag  tttgggaaa  19140
gtaattttc  aaaacctgc  tgtcattat  aatcagatt  atctacact  actctcatt  19200
tctgataaa  agtatttgc  tgtttttgt  acttatcaa  cctgtcttg  atttttctt  19260
ttttcttga  tagtacagg  actttttta  ctggtaaca  tcagcttct  aaggatgaa  19320
ttaaaacta  ttgaggttg  aaggggaat  aacatttaa  gtaccaagg  aggggctat  19380
agagtagtg  accagggca  ggcaacaat  gctctcaag  aggattcct  tgagccttt  19440
ttcctgcaa  tccttgtaa  ttgtcagaa  ctgtgtatc  agaagttgg  actgctctg  19500
ttcctctgc  ttgttggta  ctgtaggga  caagtatga  agactacaa  gggctgtag  19560
gtgtagggg  agagcttat  ccattggtt  tgctaccgt  ctgttcctt  gttcccttg  19620
tgttcagct  gcagttaaa  acaagaaag  atataattt  aactctgca  aaaagtagt  19680
ttacttctt  tttaaggta  cattttgta  ctttacaat  ttaaaataa  ctccctgct  19740
tcccctttc  ccaaatgtt  tgttgacaa  attggaaaa  agtttgtgt  ctttaataa  19800
aaccttatc  tttcattaa  aattgaaca  acctcaata  caaacacaa  aatggtaac  19860
ctgaaacca  ccacgaaat  aaagtcatt  cattgtcat  taaggaatg  ctttataac  19920
ttcatacga  ttttgggaa  tggtttctg  ccaactcat  gtatcacag  taatagact  19980
cttctgtaa  tcagctctt  gcttcagga  gagctttta  aactggatg  actttctgt  20040
gtttctgga  gtggtagag  tgtctccaa  ttgtattgt  agtttcttt  ggttattcc  20100
gcattgtct  aaggaggaa  tcaaatgtg  taaggacac  gatacataa  gaatgaagc  20160
ataaattag  gctattttc  gtttggtgg  gtttttttt  aattatttt  agtttgcat  20220
tattgtgtt  tgaggtaga  ttcacagag  gggttcctt  ctgcatttt  ttttattta  20280
tcttctatt  tgcaatttt  aattggtcc  agagcattc  ttgagaaaa  taatagcac  20340
atagtcaca  cattcacta  agtattttt  tttcttttg  gtgtatcat  ttacccact  20400
gattagttg  tcccacaag  tctgtatat  ttttggaaa  ctatcttta  atctgtgag  20460
taaaaataa  cttcagtta  taaaaaaga  tcatctgtg  tagtagtga  aatgtatat  20520
ttagaaatt  catgtatgt  gcatcattg  gaatcaaat  tgaaacatt  tttaaagga  20580
aaagagtag  aattaaaaa  aaactttga  tgtataagt  attttttga  atgagaaat  20640
atttcaata  gtttttttt  tctctagaa  cctgttgga  aatgccttg  tactccagc  20700
gaaaagcat  tctattatt  ccaatagaa  tagtgtgtt  agaaaaaga  aaggcttaa  20760
ttacagcct  ttgaagttt  agggaaaat  cctttttta  agcatgcag  aggaaagac  20820
tgacatcac  gccttaagt  ggtaaaagg  tacatggct  atacttttt  agtgattga  20880
ttattagca  gggtaataa  ttgtggaag  tgaagaggt  ccactagtt  cagtgtgtt  20940
atcttcccc  cttaaagtg  gaaataaat  cctcataag  atatatatg  ggatatagt  21000
tctttcctt  ctaagacac  tgcttgagt  agcagtggt  gcgtgtggt  acctttgga  21060
tagtcttcg  attcagaga  atgagtggg  ggtttcagt  cagtttcaa  gttgttaac  21120
caaataagt  ctagagttg  tattaattg  cccccttat  gaaaccttt  aggaggaag  21180
tgttgttac  caggtaact  tataccttt  gagtttatt  ttgcctagt  aaaattaat  21240
tggaaatat  ataaaaatt  gtagggaac  ctttcattc  tctacattg  ggtcactca  21300
gtgattcaa  ttaaatgta  ctttttttt  ttttttttt  tttgagatg  agtttcact  21360
ttgttgccc  ggctggagt  cagtggtgc  gtctcggct  actacaacc  ccgccacct  21420
ggttcaagc  tttctcctg  ctcagcctc  tgagtaact  ggattatag  tgcccacag  21480
tagctaatt  ttttgtatt  ttagtagag  cggggtttc  ccatgttgg  caggctggt  21540
tcaaactcc  gacctcagg  gatccacct  cctcggcct  ccaaagtgc  gggattaca  21600
gcgtgagcc  ccgccccag  cctgaaagt  cctttttaa  aaggaaatt  tggttaaga  21660
ttttttttg  gttagtgct  taaaaaaat  gcttatatt  aaatacaac  acgtattaa  21720
taaaaagac  taaaatcca  atttttact  tgtttgatc  gggaaacct  cctgggaaa  21780
acttaaaat  aagtctcca  cctaatgag  tttagcatc  gtgacaaaa  aggagtgga  21840
acctttacc  agcaatgtt  gagtgactc  ctggatatg  gaacaaata  ctcatttct  21900
catttttgc  tcttattta  ttattttta  gaataaata  atactcagg  tggatggag  21960
tgggagtga  ttaatgaaa  ttctaataa  aaaaggata  taaaaatta  aagagatta  22020
attaaataa  atagagttg  aaataaatt  tacctgcgg  gatgatgaa  ttgtcgttt  22080
cttattctg  aattgtttg  tagtttctt  gttgacagt  aatacatta  acagagtta  22140
ttaagaatt  taatttgct  ggacaatgc  aatgacttc  gatattaaa  ttttgttag  22200
aacttattg  tgttaaact  gttttaact  gttataaaa  aaaataata  ttgtaaaga  22260
tatttcctg  ttccctgtg  gggtgggag  gggacggag  ctctggaat  attttgaac  22320
ctagcaggt  gtcagtcat  taagagcat  ttttcatag  tgagtccca  tgattaggg  22380
actctgatg  aaatgtcat  tttgtcctg  ttgtattct  tatctcttg  tatctggat  22440
tttgaaaaa  cattttctg  tgatgttca  gtcttaaat  tataaactc  aaactttaa  22500
atatatata  aagttaaaa  tgtggtctt  ttgtttctt  tcctcttaa  acaactttt  22560
tgttcttga  tatgtttaa  atcttctgg  acataagaa  tatagtaat  aataaagca  22620
aaagtaaaa  aaagtaaaa  taaaatgcc  actgtgtcc  tgaataact  atattcagt  22680
tttgttgaa  agctcagag  ccagtaagg  ggtaatata  gtacaaaga  ccttagaat  22740
tgttacctg  tctgataga  gagctcata  ttgttcatt  attcatata  ccatttatt  22800
aacatcttt  ttttgtcac  ccataaaga  caccgtaaa  tggtccttt  ctacgtttt  22860
gcattatag  agtgaacca  ataaatgac  cttgtcctg  aggaggtct  atcccccat  22920
tttgttact  aggaacagg  attattgta  ttttgttcc  agtatccca  gtgtctaga  22980
gagtgctag  cacatagta  ttactcagt  gatgttaat  ggaggaaac  aaacaaatg  23040
cccaaacct  agctcaggt  ctcctttcc  tgttttcaa  acctggtgt  ttgaactgg  23100
ttttgaaga  taattgttg  ctaacagaa  aatgagtgg  acatcctgt  cggaggaga  23160
agtttaaac  gaggcactg  ataattggg  aatattgaa  ctcagtgtg  aagtcactt  23220
tttttttta  gtaaatcgg  attaaagta  tctgccttt  tgaacttag  agttgtaac  23280
atatactga  actaatagc  tctctttgt  gcatatatt  tttttaata  atgtgctta  23340
caggaattt  tttaagtta  gtattaaac  taatatttt  taactgaaa  atgttttca  23400
ggtacttgt  aattattaa  tagtggtag  taatttaga  gtttttagg  aggagaaat  23460
aatttcttt  tagtaagga  tttaacccc  cagtgtttt  gactcataa  gtgtacttt  23520
tttttaaaa  gtcaaaagg  ttttcagaa  tagtagtat  tgaaactat  agctaatgg  23580
tttctaaaa  tatattttt  ccttagagc  tctagagtg  ccagaattt  gtgactctt  23640
gcaagtccc  aagttgaaa  tttttacct  gtagcttgc  taattggat  taaatatgt  23700
ttttcatta  gcatgtatt  gttagaaaa  attggtgta  ttcttagtg  aacactatt  23760
tgtatttaa  ttgatttta  ttaagattt  aaataaact  ttaacattc  tcttagaaa  23820
aattttttt  aagtacttc  ttatttaaa  tatttccaa  ataatcaac  gcttattta  23880
ctgggcatg  tggcatgag  ctgcagtcc  aactactct  gggtgagga  gaggctgat  23940
tcgagccca  atgcttgag  ctagaagct  ggggctgca  tgaactatg  ttgtaccac  24000
gcactccag  tggacaaca  agtgagact  tctccctaa  gcagacaaa  aaaaaaaca  24060
cttctaaac  aaaatgaca  ataaaacta  ggcatatca  ttatttgga  tgagttgat  24120
attgtgtag  tatatgatc  taaattgtt  gaacacttt  ttttgcaac  gtttcatat  24180
tctgtaagc  tttgttggg  atttcatgc  caccccact  atatacaaa  tacaacatt  24240
tctaggcca  tgtgcttat  ctggaaaat  acattgcat  cttttattt  ctgaattat  24300
tgcataaga  caatttcaa  ggtgacagt  gtaggtctt  tttactttc  acgtgtcgt  24360
gtttaggtt  gtaacataa  acagacagg  gaaaggaat  acgtataag  aagcacaaa  24420
aagtagatg  tttagggtt  gattgataa  ggcatttct  aagtggatc  aattaagta  24480
ttaaaacaa  aggatcttc  acaaattta  acgaaatag  tttttaaca  tctgccttg  24540
ggtataaaa  agccttatt  cgcatcctt  attttaaaa  ttgtgctta  ttggctcca  24600
gaatatgca  agatgagtg  aaaagttgg  ctatcagtg  caacttatc  tttaggttt  24660
cttttaaca  tattttcat  taagttaag  tgaaattga  ataagcttt  tggatgctt  24720
taaatttca  ttcagcctg  ttgaaatca  gtcccctcc  ccttaagta  ttttctcat  24780
tccatttta  gaagaaatt  tgctaacat  tataaacag  agtaataaa  agatttcat  24840
tgccagcac  ggtaataga  tatggcttg  gttaatgtt  cagcacggc  tagagtcac  24900
gcctcactc  catagaggt  cctgataat  aaaaagcat  gtgcttcct  ggaccctca  24960
acagcatga  cagtagcaa  catgacagt  tttagttca  agtaattaa  aaaaacagt  25020
caagaaaag  tgaattctt  atagtacag  gtagtaaga  cacttttat  ggaatgtgt  25080
attttacag  aatgtttta  ggaacagag  taatggaga  tttgttaga  aagcaaatg  25140
tcctcaaca  gcacttaaa  tttatcaca  caaaatgta  tgtttgttg  cagagcagc  25200
tattttctt  cagaaatgc  tataagtga  gccaaattt  atgatagaa  ttcaattct  25260
gtcttacaa  ttcccatcc  gtagcagtg  atctgttta  taggaatta  ccctgaatg  25320
gaatgattt  agtcttaag  tgctgcacc  gttgccggg  ggtatttat  ccgatcagt  25380
gcctaaagc  gagagagtt  tatcttgac  ttttatagc  tggggggaa  aactgtctt  25440
tcaaaatca  ttgttcaga  aggagaaaa  ggagcaaaa  agttcattt  actctaagc  25500
ccgctattt  gtggtattc  catttgcac  gcacaaagc  gcaatattg  ttttttgct  25560
acagagcct  ccaccagtt  tctcttcaa  tgtcagggt  gcaagatgg  ttagattac  25620
ttttgctgg  tgggatgct  atttttttg  tgttgttga  atagaaata  actgaaaat  25680
cggcttgga  tgaatatca  agtaatagt  tggttaaaa  gctttaatt  gaggatttc  25740
ttatgttga  tatgttcac  aagccattt  cctgaccat  agacacagt  tcctttcct  25800
ttccttttc  tccccaaga  tagtagcag  cagcatacc  taacgatgt  ctttacaac  25860
ctgtcccca  acctgctgc  gatggccat  atcgtttgg  gaggcatta  agtaacatt  25920
aagaacatg  acccaggag  tgaattact  ggtttgaaa  cttaatttc  tttttattg  25980
atataactg  agaaaactt  atctttctc  gcctcaact  cctcctctg  aaaatgttg  26040
taataatgt  acctatctt  tatggttgt  ttgaggatt  ataatcagg  aatatttat  26100
cagtcctta  agggacttc  gagggtggc  aattccctc  aaaacaagt  taaaattag  26160
attgtcaac  acaaccatt  tgggagctg  aaagtaacc  aacaacaaa  ggggaaaca  26220
tatttatga  aatctacta  aacttctag  agatgttta  agccttcta  catcgggct  26280
ctccttatc  cccgcaatc  ctccatctc  tactcctta  ctatgtcat  gtggaagtt  26340
catcagggc  agattggcc  tcaaaacca  tggctttac  gccatgaag  gctgacatg  26400
tttggagta  agagtggaa  ctcatgccc  gcagtgttg  caatgaaag  aaacactgt  26460
gggaaaaaa  aaaatgggg  aaacctgta  ctctgctat  ctttggttg  agttccagt  26520
gggatgact  gaaaccatt  tgaaactta  cagggaaat  ttggaaatg  agaaaccat  26580
aactttctg  gcattctta  ctaactggg  agctaaaca  atgtacaga  gagacatga  26640
aggacttgg  agcaagtaa  taactgagt  tgacttgta  actacttga  cttttaata  26700
tctttctaa  atacaatca  atcagcaaa  agtggagac  taataatgg  cctatggtt  26760
ttgtgcaaa  tctctgccc  gtcattggc  gaccactaa  ccatgcaga  agaggtgat  26820
tctaggagc  gaggctaaa  aataaaaat  agaattcaa  cgaattaaa  taaaacagt  26880
agcaaaggt  taagcagcc  cacactgtg  gggcagaga  tctgcatat  aaatacagc  26940
gaggtatta  aaagaaacc  cgacagcag  agcaattct  aggggaaag  aatctgaaa  27000
cggagttgc  aatggtgta  tatttaaaa  gtatagttt  caacaacaa  acatttata  27060
gatacataa  gaaacagaa  agttgatcc  taaaataga  attgcctca  atgtggacc  27120
agtgttaga  ttagcatat  aggatttta  accagctat  acaaatacg  tcaaaaatc  27180
aagtaaaac  atcttggag  attaagagg  aatatgatg  caatgacaa  aaatacgta  27240
tcagagaaa  aaaaactat  tttcaaagg  cttagagac  ttctttgca  atcttagtt  27300
ttataccag  gtgctataa  taaattaat  ttttgttgt  caaattaca  atagtgtag  27360
ttcatctga  ccagagatt  tgattcagt  ggtctggga  agagcttca  gatttgtct  27420
tataaaaag  ttactaggt  attctgatg  aaccatatt  gggaatcaa  tatgtagac  27480
tggcaaagg  ttaaaacat  tatatatat  ttttttttt  tgatgattt  ttcccgtga  27540
tcagtattc  agatcatta  tgtgataca  ataaaggaa  aaataaatg  tttcaggaa  27600
gggttttta  gtcttttat  agatttatt  agtgaaaat  ttgggtttt  aaagttgat  27660
ctaattgca  taattttat  aaaggcttt  caaagttcc  ttaaagtag  attgttggt  27720
gaagaggtt  agctatatc  cttgaagtt  tcaggaaaa  agtgtaaaa  ggtcaaaga  27780
ggcacaaca  tttatattt  tcttaaaaa  gtgtgtaaa  tttttattt  ccatcagtt  27840
ttttgccaa  attaaggac  tgcccgtgc  acagcctca  gagctcctg  caacatgtg  27900
ccaaggcgg  tgggctaca  cttggtttt  tacatttta  ggagacata  gtcagaaat  27960
agtacatga  tgatgttca  tggttcagt  tggaaaggt  agacaaccc  aagggtaga  28020
ttaggattc  aggtaatag  tagattcaa  gatttcccg  ttggcaact  gttgaaggg  28080
tttgtctat  aataaagac  cgaatcaat  gaagaaagt  tctgggtta  gataggggt  28140
gtgaggacc  gggttctta  tatgcagat  aagcctcta  gtagcaggt  ttaagagag  28200
atagattgg  aatatttct  accatattt  aagaggcag  tctggccaa  cgtggtggc  28260
cacacctgt  atcccagca  tttaggagg  caaagtggg  agatcacct  aggtcagga  28320
tttgagacc  gcctggcca  catggcgaa  cctcatctc  actaaaaat  caaaaatta  28380
ccggtcatg  tggtgcgca  ctgtggtcc  atctactgg  gaggctgaa  tggaagaat  28440
acttgaacc  ggtgggtgg  ggttgcagt  agccaaaat  gcaccactg  actcctgca  28500
tccagcctg  gtgacagag  aagactcca  ctcagaaaa  aaagggtgg  gggcagttc  28560
gtcagtctt  aggtctctg  tttaatgtt  aggatagtc  gactgtgtc  gaattccaa  28620
gaaaggaaa  tacaatgag  catgtctga  cacccattc  catcatggc  acaactaga  28680
aacttttcc  taattgatt  atgtttatt  tctcttttc  actaagtca  tgattaaaa  28740
agttaacct  ggaagatgt  ttcctgtga  ttgtgtgaa  tctgcttag  ttgtcacat  28800
gacttttga  aattatttt  acagtacct  acaatctat  tggatgtgc  cagcacatc  28860
atgttaaca  tgttgttat  tttatattt  aagaaaaca  agcaagttg  ttattaatt  28920
tcgatcact  gaaatgttg  aatagcatg  gtacttgat  aaaaggagc  tgcctgttt  28980
gacttacag  ttgaggaaa  tttataaga  tttgaaatg  ctttaattc  tcagaaaag  29040
ttttaatta  aacccagag  agtaaaatg  ctttgccca  agtcacaag  ctgacccat  29100
tactcatac  tcagtgttc  gtgctcttt  catgtgtac  tacagtata  catttgctg  29160
ctttatatt  atggtacac  tgtttacat  tctacaaat  tgattttca  tactattca  29220
gtagttttg  gaaccttta  aataattat  tcttgtcag  tttactaat  tattctttg  29280
tgattttca  attgtatga  gacttataa  ataaatctt  ttattttat  agcaaaatg  29340
cttgagtag  cagagttga  cagagaagg  ttctggagt  taagctccc  gcatgggtt  29400
gaatctaac  tgtggtaag  ttgagaccc  aaatttact  ctatttgat  ccttagttt  29460
atactctgt  aaattggta  tataacagc  actattcca  tgtttattt  ttatgttgt  29520
gaacataaa  caaagtgat  catataaag  atttaagcc  gtgccagca  atagtaatt  29580
ctttgcaag  aatacttat  tctctcttc  tatttgttt  ttaaagaat  tatatatat  29640
cattatata  atatataca  tatatatac  cattatata  atacacatt  tatatacac  29700
ttatatata  acacattat  tatatatac  cattttata  acacacaca  acacacaca  29760
acacacaca  acacatatt  ggttggaaa  acagacttt  gataagaga  atgtataaa  29820
atgtaaccc  tctgtctta  gacaattcc  gtgatacat  tataataat  aattgacaa  29880
ttaaatatt  ttttggtgg  ggagatggc  tataatttt  attgataag  agtttgcct  29940
gtttttaat  ttcaccatt  gttttcact  ccaaaggaa  tagacatta  aaaggaaag  30000
acattgcaa  ttatgttgt  ttaatcact  gtttaattc  acaatttgg  tccacattt  30060
taagaatta  gtatcatgt  ctattgtag  cattgagat  ataactaag  gccttacta  30120
agtctagca  ggtagatat  tatatatac  aaaagtgaa  atgcactgt  tcacatgtt  30180
ataagcaca  tagtaaaga  taatatatc  gcatatata  agtttaatc  aaacaggta  30240
gagaaagaa  ttagaaaag  acattaatg  tttaaatca  aatacattg  aggattaaa  30300
aaagtggta  ttgctatta  gaactctta  tgcaatttc  gttgctata  gaaaatact  30360
agactgggt  atttataaa  aaaagagtt  tatttagct  atggttctg  ggttctggg  30420
tcgaaggtg  gcagccaca  ctggtgagg  cctcatgct  cttcctaga  tggttgaaa  30480
gtggaagga  aagggaatg  aaaaaacta  ttaattcct  tgagaacta  cccagtctt  30540
aaacaaaaa  tttggggct  ggcacagtg  ctcatgcct  taaccacag  actttggga  30600
gcggaggtg  gcggatcac  aggtcaagg  ttcgagacc  gcctggcca  catggtgaa  30660
ccttgtctc  actaagaat  caaaattag  ctggcgtga  ggcacatgc  tgtaatcct  30720
gctactcag  aggctgagg  aggagaatt  cttgaaccg  cgaggcaga  gttgcagtg  30780
gccaagact  tgtctcggg  tgggggcag  gggaaagaa  gagttataa  gacccagtc  30840
cctgttaaa  gcacgacct  ccagtatgg  cacactgag  actaagcct  tacttgagt  30900
tgatgggaa  aagccatat  cgaacgata  caagtacca  gatctcttt  ctccagtag  30960
ttctgtatt  gcaatctac  aaattatta  agtgcactg  tctttcttt  ctttttcct  31020
actatactt  ttttttttt  tgagatggg  gtttggctc  ttttgccca  gctagagtg  31080
agtggtgcc  tcttggctc  ctgcaaccc  cgcctccca  gttcaaatg  ttctcctgc  31140
ccagcctcc  tagtaactg  gattacagg  atgcgccac  acacccggc  agttttgta  31200
ttttagtag  gatggggtt  caccatgtt  gccaggctg  tcctgaatc  cctgacgtc  31260
ggtgatcca  ccgcctcag  ctcccaaag  gctgggatt  caagcgtga  ccacagcgc  31320
agaccttac  gtacttttc  ggatgactg  gaccaaagc  ttaagactg  catccctga  31380
ttatcaaaa  ggtaacaca  tcaactatg  caattccca  ataggtttc  aaagcagag  31440
aaaattcac  tagaatgat  actctaatc  tgcaaacta  caacaacaa  agttaaagg  31500
cttgggttt  aaaaaccac  gtgcttcat  atcagttct  tgttttgac  aaatagtaa  31560
aattgcgag  gtggctcca  gccagtctt  taataatgt  ttccaatat  cctagcatt  31620
tctaataat  gatttattc  gttttatta  agaattgta  ttgcaaatt  cctctgtat  31680
taaaatagg  tgcatttca  aattttatt  gatgtcgtt  gtttgaatt  tcacata  31737



<210> 1151
<211> 1318
<212> PRT
<213> Homo sapiens
<308> CAC19796
<400> 1151

Phe Ser Arg Ala Ala Leu Pro Phe Gly Leu Val Arg Arg Glu Leu Ser 
  1               5                  10                  15
Cys Glu Gly Tyr Ser Ile Asp Leu Arg Cys Pro Gly Ser Asp Val Ile 
             20                  25                  30
Met Ile Glu Ser Ala Asn Tyr Gly Arg Thr Asp Asp Lys Ile Cys Asp 
         35                  40                  45
Ala Asp Pro Phe Gln Met Glu Asn Thr Asp Cys Tyr Leu Pro Asp Ala 
     50                  55                  60
Phe Lys Ile Met Thr Gln Arg Cys Asn Asn Arg Thr Gln Cys Ile Val 
 65                  70                  75                  80
Val Thr Gly Ser Asp Val Phe Pro Asp Pro Cys Pro Gly Thr Tyr Lys 
                 85                  90                  95
Tyr Leu Glu Val Gln Tyr Glu Cys Val Pro Tyr Ile Phe Val Cys Pro 
             100                105                110
Gly Thr Leu Lys Ala Ile Val Asp Ser Pro Cys Ile Tyr Glu Ala Glu 
         115                120                125
Gln Lys Ala Gly Ala Trp Cys Lys Asp Pro Leu Gln Ala Ala Asp Lys 
     130                135                140
Ile Tyr Phe Met Pro Trp Thr Pro Tyr Arg Thr Asp Thr Leu Ile Glu 
 145                150                155                160
Tyr Ala Ser Leu Glu Asp Phe Gln Asn Ser Arg Gln Thr Thr Thr Tyr 
                 165                170                175
Lys Leu Pro Asn Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly 
             180                185                190
Ala Val Phe Phe Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Phe Asp 
         195                200                205
Leu Arg Thr Arg Ile Lys Ser Gly Glu Ala Ile Ile Asn Tyr Ala Asn 
     210                215                220
Tyr His Asp Thr Ser Pro Tyr Arg Trp Gly Gly Lys Thr Asp Ile Asp 
 225                230                235                240
Leu Ala Val Asp Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gln 
                 245                250                255
Asn Asn Gly Met Ile Val Ile Ser Gln Leu Asn Pro Tyr Thr Leu Arg 
             260                265                270
Phe Glu Ala Thr Trp Glu Thr Val Tyr Asp Lys Arg Ala Ala Ser Asn 
         275                280                285
Ala Phe Met Ile Cys Gly Val Leu Tyr Val Val Arg Ser Val Tyr Gln 
     290                295                300
Asp Asn Glu Ser Glu Thr Gly Lys Asn Ser Ile Asp Tyr Ile Tyr Asn 
 305                310                315                320
Thr Arg Leu Asn Arg Gly Glu Tyr Val Asp Val Pro Phe Pro Asn Gln 
                 325                330                335
Tyr Gln Tyr Ile Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Gln Leu 
             340                345                350
Tyr Val Trp Asn Asn Asn Phe Ile Leu Arg Tyr Ser Leu Glu Phe Gly 
         355                360                365
Pro Pro Asp Pro Ala Gln Val Pro Thr Thr Ala Val Thr Ile Thr Ser 
     370                375                380
Ser Ala Glu Leu Phe Lys Thr Ile Ile Ser Thr Thr Ser Thr Thr Ser 
 385                390                395                400
Gln Lys Gly Pro Met Ser Thr Thr Val Ala Gly Ser Gln Glu Gly Ser 
                 405                410                415
Lys Gly Thr Lys Pro Pro Pro Ala Val Ser Thr Thr Lys Ile Pro Pro 
             420                425                430
Ile Thr Asn Ile Phe Pro Leu Pro Glu Arg Phe Cys Glu Ala Leu Asp 
         435                440                445
Ser Lys Gly Ile Lys Trp Pro Gln Thr Gln Arg Gly Met Met Val Glu 
     450                455                460
Arg Pro Cys Pro Lys Gly Thr Arg Gly Thr Ala Ser Tyr Leu Cys Met 
 465                470                475                480
Ile Ser Thr Gly Thr Trp Asn Pro Lys Gly Pro Asp Leu Ser Asn Cys 
                 485                490                495
Thr Ser His Trp Val Asn Gln Leu Ala Gln Lys Ile Arg Ser Gly Glu 
             500                505                510
Asn Ala Ala Ser Leu Ala Asn Glu Leu Ala Lys His Thr Lys Gly Pro 
         515                520                525
Val Phe Ala Gly Asp Val Ser Ser Ser Val Arg Leu Met Glu Gln Leu 
     530                535                540
Val Asp Ile Leu Asp Ala Gln Leu Gln Glu Leu Lys Pro Ser Glu Lys 
 545                550                555                560
Asp Ser Ala Gly Arg Ser Tyr Asn Lys Ala Ile Val Asp Thr Val Asp 
                 565                570                575
Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys His Met Asn Ser 
             580                585                590
Ser Glu Gln Ala His Thr Ala Thr Met Leu Leu Asp Thr Leu Glu Glu 
         595                600                605
Gly Ala Phe Val Leu Ala Asp Asn Leu Leu Glu Pro Thr Arg Val Ser 
     610                615                620
Met Pro Thr Glu Asn Ile Val Leu Glu Val Ala Val Leu Ser Thr Glu 
 625                630                635                640
Gly Gln Ile Gln Asp Phe Lys Phe Pro Leu Gly Ile Lys Gly Ala Gly 
                 645                650                655
Ser Ser Ile Gln Leu Ser Ala Asn Thr Val Lys Gln Asn Ser Arg Asn 
             660                665                670
Gly Leu Ala Lys Leu Val Phe Ile Ile Tyr Arg Ser Leu Gly Gln Phe 
         675                680                685
Leu Ser Thr Glu Asn Ala Thr Ile Lys Leu Gly Ala Asp Phe Ile Gly 
     690                695                700
Arg Asn Ser Thr Ile Ala Val Asn Ser His Val Ile Ser Val Ser Ile 
 705                710                715                720
Asn Lys Glu Ser Ser Arg Val Tyr Leu Thr Asp Pro Val Leu Phe Thr 
                 725                730                735
Leu Pro His Ile Asp Pro Asp Asn Tyr Phe Asn Ala Asn Cys Ser Phe 
             740                745                750
Trp Asn Tyr Ser Glu Arg Thr Met Met Gly Tyr Trp Ser Thr Gln Gly 
         755                760                765
Cys Lys Leu Val Asp Thr Asn Lys Thr Arg Thr Thr Cys Ala Cys Ser 
     770                775                780
His Leu Thr Asn Phe Ala Ile Leu Met Ala His Arg Glu Ile Ala Tyr 
 785                790                795                800
Lys Asp Gly Val His Glu Leu Leu Leu Ile Ala Cys Pro Ile Phe Ala 
                 805                810                815
Gly Leu Leu His Phe Phe Phe Leu Ala Ala Phe Ala Trp Met Cys Leu 
             820                825                830
Glu Gly Val Gln Leu Tyr Leu Met Leu Val Glu Val Phe Glu Ser Glu 
         835                840                845
Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala Gly Tyr Leu Phe Pro Ala 
     850                855                860
Thr Val Val Gly Val Ser Ala Ala Ile Asp Tyr Lys Ser Tyr Gly Thr 
 865                870                875                880
Glu Lys Ala Cys Trp Leu His Val Asp Asn Tyr Phe Ile Trp Ser Phe 
                 885                890                895
Ile Gly Pro Val Thr Phe Ile Ile Leu Leu Asn Ile Ile Phe Leu Val 
             900                905                910
Ile Thr Leu Cys Lys Met Val Lys His Ser Asn Thr Leu Lys Pro Asp 
         915                920                925
Ser Ser Arg Leu Glu Asn Ile Lys Ser Trp Val Leu Gly Ala Phe Ala 
     930                935                940
Leu Leu Cys Leu Leu Gly Leu Thr Trp Ser Phe Gly Leu Leu Phe Ile 
 945                950                955                960
Asn Glu Glu Thr Ile Val Met Ala Tyr Leu Phe Thr Ile Phe Asn Ala 
                 965                970                975
Phe Gln Gly Val Phe Ile Phe Ile Phe His Cys Ala Leu Gln Lys Lys 
             980                985                990
Val Arg Lys Glu Tyr Gly Lys Cys Phe Arg His Ser Tyr Cys Cys Gly 
         995                1000                1005
Gly Leu Pro Thr Glu Ser Pro His Ser Ser Val Lys Ala Ser Thr Thr 
     1010                1015                1020
Arg Thr Ser Ala Arg Tyr Ser Ser Gly Thr Gln Ser Arg Ile Arg Arg 
 1025                1030                1035                1040
Met Trp Asn Asp Thr Val Arg Lys Gln Ser Glu Ser Ser Phe Ile Ser 
                 1045                1050                1055
Gly Asp Ile Asn Ser Thr Ser Thr Leu Asn Gln Gly His Ser Leu Asn 
             1060                1065                1070
Asn Ala Arg Asp Thr Ser Ala Met Asp Thr Leu Pro Leu Asn Gly Asn 
         1075                1080                1085
Phe Asn Asn Ser Tyr Ser Leu His Lys Gly Asp Tyr Asn Asp Ser Val 
     1090                1095                1100
Gln Val Val Asp Cys Gly Leu Ser Leu Asn Asp Thr Ala Phe Glu Lys 
 1105                1110                1115                1120
Met Ile Ile Ser Glu Leu Val His Asn Asn Leu Arg Gly Ser Ser Lys 
                 1125                1130                1135
Thr His Asn Leu Glu Leu Thr Leu Pro Val Lys Pro Val Ile Gly Gly 
             1140                1145                1150
Ser Ser Ser Glu Asp Asp Ala Ile Val Ala Asp Ala Ser Ser Leu Met 
         1155                1160                1165
His Ser Asp Asn Pro Gly Leu Glu Leu His His Lys Glu Leu Glu Ala 
     1170                1175                1180
Pro Leu Ile Pro Gln Arg Thr His Ser Leu Leu Tyr Gln Pro Gln Lys 
 1185                1190                1195                1200
Lys Val Lys Ser Glu Gly Thr Asp Ser Tyr Val Ser Gln Leu Thr Ala 
                 1205                1210                1215
Glu Ala Glu Asp His Leu Gln Ser Pro Asn Arg Asp Ser Leu Tyr Thr 
             1220                1225                1230
Ser Met Pro Asn Leu Arg Asp Ser Pro Tyr Pro Glu Ser Ser Pro Asp 
         1235                1240                1245
Met Glu Glu Asp Leu Ser Pro Ser Arg Arg Ser Glu Asn Glu Asp Ile 
     1250                1255                1260
Tyr Tyr Lys Ser Met Pro Asn Leu Gly Ala Gly His Gln Leu Gln Met 
 1265                1270                1275                1280
Cys Tyr Gln Ile Ser Arg Gly Asn Ser Asp Gly Tyr Ile Ile Pro Ile 
                 1285                1290                1295
Asn Lys Glu Gly Cys Ile Pro Glu Gly Asp Val Arg Glu Gly Gln Met 
             1300                1305                1310
Gln Leu Val Thr Ser Leu 
         1315



<210> 1152
<211> 5564
<212> DNA
<213> Rattus norvegicus
<308> AF081144
<400> 1152

ttttaaatt  tggttggtg  cggcagtgc  gggccggag  aaagaaggg  cacggagtc  60
tccctcgct  agccacccc  tccccgctt  cccctgggc  gggctccgg  agatgtgcc  120
ggcgggggg  ccggcttcg  ggagccgcg  gaggagcgc  cacggccga  cccgaagcg  180
cgctggaca  gctggtggg  caggccttg  taccctggt  atgcggggc  aggcccccc  240
cacagtccg  tgagatcac  gtgcccgcc  ctggccttc  ccatggccc  cttggctgc  300
gcactctgg  gtctctgtg  gacgactgt  ctcgtcacc  ctgctaccc  aggcctgag  360
cgggctgga  tcccatttg  attgatgcg  cgggagcta  catgcgaag  ctaccccat  420
gagctgcgg  gcccgggca  tgacgtcat  atggtggag  atgcaaact  tgggcgcac  480
gatgacaag  tctgcgatg  cgacccttt  cagatggag  acgtgcagt  ctacctgcc  540
gacgccttc  aaatcatgt  acagagatg  aataaccga  cccagtgtg  ggtggtggc  600
ggctctgac  cctttcctg  cccctgtcc  ggaacctac  agtacctgg  ggtgcagta  660
gactgtgtc  cttacatct  cgtgtgccc  gggacactg  agaaggtgc  ggagcccac  720
tccacacat  aatcggagc  ccagtctgg  gcatggtgc  aggacccac  gcaggcagg  780
gaccgtatc  acgttatgc  ctggatccc  taccgcacg  acacactga  cgagtatgc  840
tcctgggag  actatgtgg  tgcacgcca  accaccacg  acagactgc  caaccgtgt  900
gatggcact  gctttgtgg  atatgatgg  gccgtcttc  ataacaagg  acgtactcg  960
aacattgtc  aatatgacc  gcggacccg  atcaagagc  gagaaacag  cataaacac  1020
gccaactac  acgacacct  accttatcg  tggggaggc  aaaccgaca  tgacctggc  1080
gtggatgag  acgggctgt  ggtcatcta  gccaccgag  ggaacaacg  gcgtctggt  1140
gtgagccag  tcaacccct  cacactgcg  ttcgagggc  cctgggaaa  aggctatga  1200
aagcgctca  cctccaatg  cttcatggt  tgtggtgtc  tctatgtgc  gcgctctgt  1260
tatgtggat  acgacagtg  ggcagcagg  aaccgcgtg  actatgcct  taacaccaa  1320
gcaaaccga  aggagcccg  cagtctcgc  ttccccaac  cctaccagt  tgtatcttc  1380
gttgactac  atccccggg  caaccagct  tatgtgtgg  acaactatt  cgtggtgcg  1440
tacagcctg  agtttggac  cccagatcc  agtgctggc  cagccactt  cccacctct  1500
agtaccacc  ccacagctc  gcctacgcc  ctcaccagc  cagcctcac  tgcagccac  1560
actccactc  gccgggcgc  cctcaccac  cacccagta  gtgccatca  ccagctggg  1620
cctgacctg  ctccagcca  agccccagc  cccagtacc  ggcggcctc  agcccccaa  1680
ctgcatgtg  cccctgagc  cttctgtga  ccccgagag  tccggcggg  ccagtggcc  1740
gctacccag  agggtatgc  ggtagagag  ccttgcccc  agggaactc  aggaattgc  1800
tcgttccag  gcctcccag  tctggggct  tggaatcct  ggggccctg  cctcagcaa  1860
tgcacttcc  cctgggtca  ccaagtcgc  cagaagatc  agagtggag  gaatgcagc  1920
aacattgct  gtgagctgg  ccgccacac  cggggctcc  tctatgctg  ggacgtgtc  1980
tcatcggtg  agctgatgg  gcaactgct  gatatcctg  atgcccagc  ccaggccct  2040
cggcccatt  aacgagagt  agctggcaa  aactacaat  agatgcaca  gcgagagag  2100
acctgcaag  actatatca  ggctgtggt  gagacagtg  acaacctgc  tcggccaga  2160
gcacttgag  catggaaag  catgaatgc  accgaacag  tccatacgg  caccatgct  2220
ctagatgtc  tagaggagg  tgccttcct  ctggccgac  atgtcagag  acctgctcg  2280
ttcttggct  ccaagcaga  tgtggtcct  gaggtcact  tcctgagca  agagggtca  2340
gtgcaggag  tggtgttcc  ccaggagta  gccagtgag  gctccattc  gctgtccgc  2400
aacaccatc  agcagaaca  ccgcaatgg  gtggtgaag  ttgtcttca  tctctacaa  2460
aacctgggc  tcttcttgt  cacggagaa  gccacagtg  agctggcag  tgaggcagg  2520
accggtggc  ctggaggtg  ctccctggt  gttaactca  aggtcatcg  agcatccat  2580
aataaggag  ccagccgtg  cttcctcat  gaccctgtc  tctttactg  ggcccactt  2640
gaggccaag  accacttca  tgcaaactg  tccttctgg  actactcag  gcgctccat  2700
ctgggctac  ggtcaaccc  gggctgccg  ctggtggag  ccaataaga  ccataccac  2760
tgtgcctgc  gccacctca  caacttcgc  gtgctcatg  ctcaccgag  gatctacca  2820
ggccgtatt  atgagctgt  gctgtcagt  atcacctgg  ttggcattg  catctccct  2880
gtctgtctg  ctatctgca  ctccacctt  tgcttcctg  ggggcctgc  gaccgaccg  2940
aacaccatc  acaagaacc  gtgcatcaa  ctcttcctt  cagagctgc  cttcctggt  3000
ggaatagac  aaactcagt  tgaggtcgc  tgccctatc  ttgcgggcc  gctgcacta  3060
ttcttcctg  ccgccttct  ctggctgtg  ctagagggc  tgcacctct  cctcctgct  3120
gtcgaggtg  tcgagagcg  atattcacg  accaagtac  attacctgg  cggctactg  3180
ttcccagcc  tggtggtag  catcgcagc  gccattgac  accgaagct  cggcactga  3240
aaggcctgc  ggctgaggg  ggataacta  ttcatctgg  gcttcattg  gcccgtctc  3300
tttgttatt  tggtgaacc  ggtgttcct  atggtgacc  tgcacaaga  gatccgaag  3360
tcatccgtg  tcaagcctg  ctccagccg  cttgacaac  tcaagtcct  ggcgctggg  3420
gccattgca  tgctcttcc  gctgggcct  acctgggct  tcggcctcc  cttcatcaa  3480
aaggagtca  tagtaatgg  ttacctctt  acaaccttc  acgccttcc  gggggtctt  3540
atctttgtc  ttcactgcg  cttacagaa  aaggtgcac  aggagtaca  caagtgcct  3600
cgtcactcc  actgctgca  tcgctcccc  cctgggggg  ctcacggct  ccttaagac  3660
tcagccatg  gaagtaaca  ccgctacta  acagggacc  agagccgaa  ccggaggat  3720
tggaatgac  ccgtgagga  gcagacaga  tcgtccttt  tggcagggg  catcaacag  3780
acccccacc  tgaaccgag  taccatggg  aaccaccta  tgaccaacc  tgtgctaca  3840
ccccgtggg  gcactagcc  atacaatac  ctcattgca  agtctgtgg  cttcaatcc  3900
tcctcgccc  cagtcttca  ctccccagg  agctacagg  aacctaagc  ccccttggg  3960
ggccgggaa  cctgtggca  ggacacact  ccccttaat  gcaacttca  caacagcta  4020
tccttgcga  gtggtgatt  ccctccggg  gatgggggt  ctgagccac  ccgaggccg  4080
aacctagcg  atgctgcgg  ctttgagaa  atgatcatc  cagagctgg  gcacaacaa  4140
cttcggggg  ccagtgggg  cgccaaagg  cctccacca  agcctcctg  gccacccgt  4200
ccaggagtc  gtgaggacg  ggctggtgg  cctgggggt  ctgaccggg  tgagattga  4260
cttctctac  aggccctgg  ggagccact  ctgctgccc  gggcccagt  ggtgctgta  4320
cagagtgat  tggatgagt  ggagagctg  acggcagag  atggggcca  cagccggcc  4380
ctctcctcc  ctcccggcc  ggactccct  tatgccagc  gggccaacc  gcgggactc  4440
ccctcctac  cggacagca  ccccgaagg  cctaatgag  ccctgcccc  tcccccacc  4500
gctccccct  ggcccccag  aatctacta  acctctcgc  cgccggccc  ggtggctcg  4560
aatccccta  agggctact  ccaggtgcg  cggcccagc  atgagggct  cctggcagc  4620
cccagcctt  aggggccag  gcccgatgg  gatgggcaa  tgcagttgg  cactagtct  4680
tgaggggcc  catggacca  aggcctggc  agggaggga  tccaggagg  gctctggtg  4740
gagcagaga  tgatggagg  agtggctgg  gggccactc  ctccaggtg  ccctctgcc  4800
gtgggcccc  cagtcccct  ggggactat  acctgggcc  caggtgcca  ggttagtag  4860
cagggtttc  accagccac  agccccagc  tctttaggg  agtgcattg  ggagaagcc  4920
ccagggccc  aggagtgag  gagaagctg  taggtgtga  caacgtcca  agctccctc  4980
ctttggagg  agaaagcaa  ggataaggc  tccctaggt  tacaggggt  gccactttt  5040
aggtggccg  agccttgca  gatacaccc  atctgctgc  cactcttct  cgtccacca  5100
aaaggagca  tgggacaga  ggacagggt  cttccatgc  acagttcct  gcttcttgg  5160
gactgggcc  tacatcctg  gagagccca  gcccagggg  tggatgggg  tgtgagggc  5220
ggtggttaa  ggtggaact  tctctgaag  tcctttctc  cttgctatt  gtccctatc  5280
cccgagcaa  cctacccta  acccccaga  tgcacccaa  gaccccctc  cttggggtg  5340
ctcctgatg  agcacaact  cccgcaggg  cccaaccca  tgcagtggc  atatttggg  5400
agttcccag  cctgtgggc  gggctatct  gggagcaga  gtggggtct  gggctccct  5460
aggagtggg  cctgggttt  gatctttcc  tagggggtc  tcttaccct  ctcttcctc  5520
cctattgct  taaatattt  aacaaaatg  aaaaaaaaa  aaaa  5564



<210> 1153
<211> 1515
<212> PRT
<213> Rattus norvegicus
<308> AAC62650
<400> 1153

Met Ala Arg Leu Ala Ala Ala Leu Trp Ser Leu Cys Val Thr Thr Val 
  1               5                  10                  15
Leu Val Thr Ser Ala Thr Gln Gly Leu Ser Arg Ala Gly Leu Pro Phe 
             20                  25                  30
Gly Leu Met Arg Arg Glu Leu Ala Cys Glu Gly Tyr Pro Ile Glu Leu 
         35                  40                  45
Arg Cys Pro Gly Ser Asp Val Ile Met Val Glu Asn Ala Asn Tyr Gly 
     50                  55                  60
Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu Asn 
 65                  70                  75                  80
Val Gln Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Ser Gln Arg Cys 
                 85                  90                  95
Asn Asn Arg Thr Gln Cys Val Val Val Ala Gly Ser Asp Ala Phe Pro 
             100                105                110
Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Asp Cys 
         115                120                125
Val Pro Tyr Lys Val Glu Gln Lys Val Phe Val Cys Pro Gly Thr Leu 
     130                135                140
Gln Lys Val Leu Glu Pro Thr Ser Thr His Glu Ser Glu His Gln Ser 
 145                150                155                160
Gly Ala Trp Cys Lys Asp Pro Leu Gln Ala Gly Asp Arg Ile Tyr Val 
                 165                170                175
Met Pro Trp Ile Pro Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ala Ser 
             180                185                190
Trp Glu Asp Tyr Val Ala Ala Arg His Thr Thr Thr Tyr Arg Leu Pro 
         195                200                205
Asn Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe 
     210                215                220
Tyr Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Tyr Asp Leu Arg Thr 
 225                230                235                240
Arg Ile Lys Ser Gly Glu Thr Val Ile Asn Thr Ala Asn Tyr His Asp 
                 245                250                255
Thr Ser Pro Tyr Arg Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val 
             260                265                270
Asp Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gly Asn Asn Gly 
         275                280                285
Arg Leu Val Val Ser Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Gly 
     290                295                300
Thr Trp Glu Thr Gly Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met 
 305                310                315                320
Val Cys Gly Val Leu Tyr Val Leu Arg Ser Val Tyr Val Asp Asp Asp 
                 325                330                335
Ser Glu Ala Ala Gly Asn Arg Val Asp Tyr Ala Phe Asn Thr Asn Ala 
             340                345                350
Asn Arg Glu Glu Pro Val Ser Leu Ala Phe Pro Asn Pro Tyr Gln Phe 
         355                360                365
Val Ser Ser Val Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp 
     370                375                380
Asn Asn Tyr Phe Val Val Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp 
 385                390                395                400
Pro Ser Ala Gly Pro Ala Thr Ser Pro Pro Leu Ser Thr Thr Thr Thr 
                 405                410                415
Ala Arg Pro Thr Pro Leu Thr Ser Thr Ala Ser Pro Ala Ala Thr Thr 
             420                425                430
Pro Leu Arg Arg Ala Pro Leu Thr Thr His Pro Val Gly Ala Ile Asn 
         435                440                445
Gln Leu Gly Pro Asp Leu Pro Pro Ala Thr Ala Pro Ala Pro Ser Thr 
     450                455                460
Arg Arg Pro Pro Ala Pro Asn Leu His Val Ser Pro Glu Leu Phe Cys 
 465                470                475                480
Glu Pro Arg Glu Val Arg Arg Val Gln Trp Pro Ala Thr Gln Gln Gly 
                 485                490                495
Met Leu Val Glu Arg Pro Cys Pro Lys Gly Thr Arg Gly Ile Ala Ser 
             500                505                510
Phe Gln Cys Leu Pro Ala Leu Gly Leu Trp Asn Pro Arg Gly Pro Asp 
         515                520                525
Leu Ser Asn Cys Thr Ser Pro Trp Val Asn Gln Val Ala Gln Lys Ile 
     530                535                540
Lys Ser Gly Glu Asn Ala Ala Asn Ile Ala Ser Glu Leu Ala Arg His 
 545                550                555                560
Thr Arg Gly Ser Ile Tyr Ala Gly Asp Val Ser Ser Ser Val Lys Leu 
                 565                570                575
Met Glu Gln Leu Leu Asp Ile Leu Asp Ala Gln Leu Gln Ala Leu Arg 
             580                585                590
Pro Ile Glu Arg Glu Ser Ala Gly Lys Asn Tyr Asn Lys Met His Lys 
         595                600                605
Arg Glu Arg Thr Cys Lys Asp Tyr Ile Lys Ala Val Val Glu Thr Val 
     610                615                620
Asp Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys Asp Met Asn 
 625                630                635                640
Ala Thr Glu Gln Val His Thr Ala Thr Met Leu Leu Asp Val Leu Glu 
                 645                650                655
Glu Gly Ala Phe Leu Leu Ala Asp Asn Val Arg Glu Pro Ala Arg Phe 
             660                665                670
Leu Ala Ala Lys Gln Asn Val Val Leu Glu Val Thr Val Leu Ser Thr 
         675                680                685
Glu Gly Gln Val Gln Glu Leu Val Phe Pro Gln Glu Tyr Ala Ser Glu 
     690                695                700
Ser Ser Ile Gln Leu Ser Ala Asn Thr Ile Lys Gln Asn Ser Arg Asn 
 705                710                715                720
Gly Val Val Lys Val Val Phe Ile Leu Tyr Asn Asn Leu Gly Leu Phe 
                 725                730                735
Leu Ser Thr Glu Asn Ala Thr Val Lys Leu Ala Gly Glu Ala Gly Thr 
             740                745                750
Gly Gly Pro Gly Gly Ala Ser Leu Val Val Asn Ser Gln Val Ile Ala 
         755                760                765
Ala Ser Ile Asn Lys Glu Ser Ser Arg Val Phe Leu Met Asp Pro Val 
     770                775                780
Ile Phe Thr Val Ala His Leu Glu Ala Lys Asn His Phe Asn Ala Asn 
 785                790                795                800
Cys Ser Phe Trp Asn Tyr Ser Glu Arg Ser Met Leu Gly Tyr Trp Ser 
                 805                810                815
Thr Gln Gly Cys Arg Leu Val Glu Ser Asn Lys Thr His Thr Thr Cys 
             820                825                830
Ala Cys Ser His Leu Thr Asn Phe Ala Val Leu Met Ala His Arg Glu 
         835                840                845
Ile Tyr Gln Gly Arg Ile Asn Glu Leu Leu Leu Ser Val Ile Thr Trp 
     850                855                860
Val Gly Ile Val Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Ser Thr 
 865                870                875                880
Phe Cys Phe Leu Arg Gly Leu Gln Thr Asp Arg Asn Thr Ile His Lys 
                 885                890                895
Asn Leu Cys Ile Asn Leu Phe Leu Ala Glu Leu Leu Phe Leu Val Gly 
             900                905                910
Ile Asp Lys Thr Gln Tyr Glu Val Ala Cys Pro Ile Phe Ala Gly Leu 
         915                920                925
Leu His Tyr Phe Phe Leu Ala Ala Phe Ser Trp Leu Cys Leu Glu Gly 
     930                935                940
Val His Leu Tyr Leu Leu Leu Val Glu Val Phe Glu Ser Glu Tyr Ser 
 945                950                955                960
Arg Thr Lys Tyr Tyr Tyr Leu Gly Gly Tyr Cys Phe Pro Ala Leu Val 
                 965                970                975
Val Gly Ile Ala Ala Ala Ile Asp Tyr Arg Ser Tyr Gly Thr Glu Lys 
             980                985                990
Ala Cys Trp Leu Arg Val Asp Asn Tyr Phe Ile Trp Ser Phe Ile Gly 
         995                1000                1005
Pro Val Ser Phe Val Ile Val Val Asn Leu Val Phe Leu Met Val Thr 
     1010                1015                1020
Leu His Lys Met Ile Arg Ser Ser Ser Val Leu Lys Pro Asp Ser Ser 
 1025                1030                1035                1040
Arg Leu Asp Asn Ile Lys Ser Trp Ala Leu Gly Ala Ile Ala Leu Leu 
                 1045                1050                1055
Phe Leu Leu Gly Leu Thr Trp Ala Phe Gly Leu Leu Phe Ile Asn Lys 
             1060                1065                1070
Glu Ser Val Val Met Ala Tyr Leu Phe Thr Thr Phe Asn Ala Phe Gln 
         1075                1080                1085
Gly Val Phe Ile Phe Val Phe His Cys Ala Leu Gln Lys Lys Val His 
     1090                1095                1100
Lys Glu Tyr Ser Lys Cys Leu Arg His Ser Tyr Cys Cys Ile Arg Ser 
 1105                1110                1115                1120
Pro Pro Gly Gly Ala His Gly Ser Leu Lys Thr Ser Ala Met Arg Ser 
                 1125                1130                1135
Asn Thr Arg Tyr Tyr Thr Gly Thr Gln Val Pro Gly Gln Gly Arg His 
             1140                1145                1150
Ile His Gln Val Ser Leu Gly Pro Arg Gly Arg Ser Ala Leu Pro Glu 
         1155                1160                1165
Ser Gln Lys Asp Pro Gly Gly Gln Ser Gly Pro Gly Asp Pro Leu Thr 
     1170                1175                1180
Phe Gly Leu Cys Pro Ser Arg Ile Arg Arg Met Trp Asn Asp Thr Val 
 1185                1190                1195                1200
Arg Lys Gln Thr Glu Ser Ser Phe Met Ala Gly Asp Ile Asn Ser Thr 
                 1205                1210                1215
Pro Thr Leu Asn Arg Gly Thr Met Gly Asn His Leu Leu Thr Asn Pro 
             1220                1225                1230
Val Leu Gln Pro Arg Gly Gly Thr Ser Pro Tyr Asn Thr Leu Ile Ala 
         1235                1240                1245
Glu Ser Val Gly Phe Asn Pro Ser Ser Pro Pro Val Phe Asn Ser Pro 
     1250                1255                1260
Gly Ser Tyr Arg Glu Pro Lys His Pro Leu Gly Gly Arg Glu Ala Cys 
 1265                1270                1275                1280
Gly Met Asp Thr Leu Pro Leu Asn Gly Asn Phe Asn Asn Ser Tyr Ser 
                 1285                1290                1295
Leu Arg Ser Gly Asp Phe Pro Pro Gly Asp Gly Gly Pro Glu Pro Pro 
             1300                1305                1310
Arg Gly Arg Asn Leu Ala Asp Ala Ala Ala Phe Glu Lys Met Ile Ile 
         1315                1320                1325
Ser Glu Leu Val His Asn Asn Leu Arg Gly Ala Ser Gly Gly Ala Lys 
     1330                1335                1340
Gly Pro Pro Pro Glu Pro Pro Val Pro Pro Val Pro Gly Val Ser Glu 
 1345                1350                1355                1360
Asp Glu Ala Gly Gly Pro Gly Gly Ala Asp Arg Ala Glu Ile Glu Leu 
                 1365                1370                1375
Leu Tyr Lys Ala Leu Glu Glu Pro Leu Leu Leu Pro Arg Ala Gln Ser 
             1380                1385                1390
Val Leu Tyr Gln Ser Asp Leu Asp Glu Ser Glu Ser Cys Thr Ala Glu 
         1395                1400                1405
Asp Gly Ala Thr Ser Arg Pro Leu Ser Ser Pro Pro Gly Arg Asp Ser 
     1410                1415                1420
Leu Tyr Ala Ser Gly Ala Asn Leu Arg Asp Ser Pro Ser Tyr Pro Asp 
 1425                1430                1435                1440
Ser Ser Pro Glu Gly Pro Asn Glu Ala Leu Pro Pro Pro Pro Pro Ala 
                 1445                1450                1455
Pro Pro Gly Pro Pro Glu Ile Tyr Tyr Thr Ser Arg Pro Pro Ala Leu 
             1460                1465                1470
Val Ala Arg Asn Pro Leu Gln Gly Tyr Tyr Gln Val Arg Arg Pro Ser 
         1475                1480                1485
His Glu Gly Tyr Leu Ala Ala Pro Ser Leu Glu Gly Pro Gly Pro Asp 
     1490                1495                1500
Gly Asp Gly Gln Met Gln Leu Val Thr Ser Leu 
 1505                1510                1515



<210> 1154
<211> 3624
<212> DNA
<213> Rattus norvegicus
<308> AF081196
<400> 1154

gcgcctggg  cggctcgcc  ggctccgag  gtggccggc  ccgggctgc  agggccggc  60
gcggccgag  gatgcgccg  tcccggccg  gccgatccc  ccgctccag  tgagacggc  120
ccaggggcg  agagagccg  ggccatggg  accctgggc  aggcgagag  ggctccgcg  180
aaaccttgc  atggctcca  agctggccc  aaaggaaga  tagaggcca  atcaaccaa  240
agtcctctc  ctgcccagc  cagcttggc  cagatcacc  agttccgaa  gatggtgtc  300
ctgggacat  tggccaaag  agccagcct  gatgatctt  ttgacagct  cattcaatc  360
ttcgatgca  atggaaacc  gtgtcgaag  aaccagctg  tacaagtca  gctaaccat  420
caccgaatc  tcatctcct  ggccgagct  ctgcaaaaa  tcatgaatc  atataagga  480
gccctggaa  agaattctc  aggaatttg  ttgaagatc  gctattttg  caggtattg  540
ataacagaa  tctggatca  gttcaaaat  gatgccagc  tgaccagca  catggaaga  600
tttcaggac  tggtgaaag  caatggtga  gagtcccac  gccacctca  cgacacgac  660
caaattaat  ctcgagact  gtccaggaa  ctgactcag  ggataaaat  aaataccag  720
aagaagcgg  aagtgtccc  gctgtttga  catcttgaa  ctgaagaac  gtctgaaca  780
ctcacctac  ttgagttca  gtccttccg  cggatatct  tctctgatt  tcagaatta  840
cttgtaaac  gctgcgtaa  ggagaaccc  accatggag  ggtccattg  cctgtgcaa  900
ggcatctcc  agtgggtac  actgatggt  ctcagccgt  ccaccccac  gctccgggc  960
gaggtcttc  tcaagttca  ccatgtggc  cagaagctc  accagctac  gaacttcaa  1020
acgctaatg  ctgtgatcg  gggactgtg  cacagctcc  tctccaggc  caaggagac  1080
agttcacat  tcccacatg  gatcaataa  gttctgggt  agatgactg  actgctgtc  1140
tcctgcaga  actatgaca  ctacaggcg  gcctatggt  agtgcaccc  cttcaaaat  1200
cccatactg  gtgtgcacc  caaggacct  atatcccta  atgaagcca  gcctgacta  1260
ctggaagac  ggaaggtga  tgtccaaaa  ctcctggcc  tttacaatc  catcaatga  1320
ttggtccag  tgcaggacg  ggccccacc  ttggatgcc  acaaggacc  ggtgcacct  1380
ctgacgtta  ccctggatc  atactacac  gaagatgaa  tctatgagc  ttcctacgc  1440
cgtgaacca  ggaaccaca  ggccccgcc  ctgacacct  cgaagccac  agttgtagt  1500
gactgggcc  ctggagtgt  tcccaaacc  gacccgaag  ccatcagca  acacgtcca  1560
aggatggtg  attctgtct  taagaacta  gatctcgac  aggatggat  tatctctca  1620
gaggagttt  aaaagattg  tgcgagctt  ccattttcc  tctgtgtga  ggacaaaga  1680
agggagggc  tcatcagca  agacgagat  acagcctac  tcatgaggg  cagctccat  1740
tattccaag  tgggcctag  ctttccaca  aactttcaa  agaccactt  cctgaagcc  1800
accttctgt  acaactgtg  tggctttct  tggggtgtg  tcaagcaag  ctatcgctg  1860
aaagactgt  ggatgaact  ccacaaaca  tgcaaagac  tggtagtgt  tgagtgcaa  1920
aaacgatcc  agagcccgg  ggtatccac  gaaaacatc  gctctgtgg  gccaatgtc  1980
actctttgt  cactgggaa  caaagatct  ctccatgca  ccgaagaag  atctttcat  2040
ttccagaat  gagaggttg  ggaccacag  gaggagagc  aggatagga  catcatgct  2100
ttgggcgta  cctcacaga  aatttcagt  cggctgaag  ggactgttg  ccacaagac  2160
acccagaca  aatcatttc  ttgggttgg  ggcgagatg  cccctggtc  ctttgtgct  2220
acttctcca  gaaagtcag  acaaggggc  ctttatgtg  acagtccag  atctccgtg  2280
cccagccca  cactggtcc  gaagcgggc  ttcgtcaag  gggagaaca  agagtccct  2340
atcaaacca  aaccagagc  tcacctcag  ctccggacc  accaagaac  ggaacagga  2400
gtaaatacc  tgagggcag  taacgatgc  ctgaagatc  agctgaagt  tgcacagaa  2460
caaatagaa  ccctgcagc  tggcaaaag  aatcacgtc  tagcacaga  ggaccacgg  2520
gatggtact  aatccagaa  ttcaaggaa  agaatctgc  gacgggttt  ctgggatct  2580
acttcaaaa  tgattgcag  ggttcagca  ctttagact  attgacttt  aaagggcag  2640
gatagccac  gttattggt  tccttggtt  tttccctaa  tgtctttaa  gtgagtcgt  2700
ggttttcag  cagttgagt  aaagggaag  aaagttcca  catgtaaaa  actgagcag  2760
catattcta  ccttttctt  cttttactg  aaccaatac  aaacatgtg  taaaataag  2820
gtatagttt  ctgacagtg  ctcaggcag  ctgctttac  gattcgcac  tagataaag  2880
gcccctggt  aatcaattt  ctgccttcc  cagggtttc  gcaaactgg  agttacttt  2940
ttctacccg  aaacctgct  ataatggaa  caataccct  aaagtggtg  ctttgacat  3000
cctgcattg  ttgtgaagc  gatccctac  ttattcact  cctcagatc  caagagcct  3060
tttccctgt  ctttacttg  cccctattt  ctcccttgc  tgtaggcac  tcagcatat  3120
tacctagaa  tgacctcct  gagatgtag  ctgtgttta  atccagagc  tcttaattg  3180
acttgacat  gtctgattg  aggccaact  atagctcta  gtcttagtc  ttatgaaat  3240
caaaataaa  ctacccata  tcatcaatt  ccatgtcat  cacagaact  attatctaa  3300
tcaaacgac  taaacacgc  tgtccagat  gtctttctt  agtggatag  attaacaat  3360
tgtgacctt  taaaagaca  ggtctgtga  cagtgttta  ttcttcacg  tctagtctc  3420
ctctctctc  ctctctctc  ctctctctc  ctctctctc  ctctcaagt  aactatcgt  3480
aggtcctct  ttgaactga  tctgtgctt  aaattgtct  cacttttat  atctacaaa  3540
aagctatgg  aggcgatgg  tttaacagc  gacagcatt  acctatgtg  agaatatgt  3600
tatatagta  caggcatgc  tgga  3624



<210> 1155
<211> 795
<212> PRT
<213> Rattus norvegicus
<308> AAC79700
<400> 1155

Met Gly Thr Leu Gly Lys Ala Arg Glu Ala Pro Arg Lys Pro Cys His 
  1               5                  10                  15
Gly Ser Arg Ala Gly Pro Lys Gly Arg Leu Glu Ala Lys Ser Thr Asn 
             20                  25                  30
Ser Pro Leu Pro Ala Gln Pro Ser Leu Ala Gln Ile Thr Gln Phe Arg 
         35                  40                  45
Met Met Val Ser Leu Gly His Leu Ala Lys Gly Ala Ser Leu Asp Asp 
     50                  55                  60
Leu Ile Asp Ser Cys Ile Gln Ser Phe Asp Ala Asp Gly Asn Leu Cys 
 65                  70                  75                  80
Arg Ser Asn Gln Leu Leu Gln Val Met Leu Thr Met His Arg Ile Ile 
                 85                  90                  95
Ile Ser Ser Ala Glu Leu Leu Gln Lys Leu Met Asn Leu Tyr Lys Asp 
             100                105                110
Ala Leu Glu Lys Asn Ser Pro Gly Ile Cys Leu Lys Ile Cys Tyr Phe 
         115                120                125
Val Arg Tyr Trp Ile Thr Glu Phe Trp Ile Met Phe Lys Met Asp Ala 
     130                135                140
Ser Leu Thr Ser Thr Met Glu Glu Phe Gln Asp Leu Val Lys Ala Asn 
 145                150                155                160
Gly Glu Glu Ser His Cys His Leu Ile Asp Thr Thr Gln Ile Asn Ser 
                 165                170                175
Arg Asp Trp Ser Arg Lys Leu Thr Gln Arg Ile Lys Ser Asn Thr Ser 
             180                185                190
Lys Lys Arg Lys Val Ser Leu Leu Phe Asp His Leu Glu Pro Glu Glu 
         195                200                205
Leu Ser Glu His Leu Thr Tyr Leu Glu Phe Lys Ser Phe Arg Arg Ile 
     210                215                220
Ser Phe Ser Asp Tyr Gln Asn Tyr Leu Val Asn Ser Cys Val Lys Glu 
 225                230                235                240
Asn Pro Thr Met Glu Arg Ser Ile Ala Leu Cys Asn Gly Ile Ser Gln 
                 245                250                255
Trp Val Gln Leu Met Val Leu Ser Arg Pro Thr Pro Gln Leu Arg Ala 
             260                265                270
Glu Val Phe Ile Lys Phe Ile His Val Ala Gln Lys Leu His Gln Leu 
         275                280                285
Gln Asn Phe Asn Thr Leu Met Ala Val Ile Gly Gly Leu Cys His Ser 
     290                295                300
Ser Ile Ser Arg Leu Lys Glu Thr Ser Ser His Val Pro His Glu Ile 
 305                310                315                320
Asn Lys Val Leu Gly Glu Met Thr Glu Leu Leu Ser Ser Cys Arg Asn 
                 325                330                335
Tyr Asp Asn Tyr Arg Arg Ala Tyr Gly Glu Cys Thr His Phe Lys Ile 
             340                345                350
Pro Ile Leu Gly Val His Leu Lys Asp Leu Ile Ser Leu Tyr Glu Ala 
         355                360                365
Met Pro Asp Tyr Leu Glu Asp Gly Lys Val Asn Val Gln Lys Leu Leu 
     370                375                380
Ala Leu Tyr Asn His Ile Asn Glu Leu Val Gln Leu Gln Asp Val Ala 
 385                390                395                400
Pro Pro Leu Asp Ala Asn Lys Asp Leu Val His Leu Leu Thr Leu Ser 
                 405                410                415
Leu Asp Leu Tyr Tyr Thr Glu Asp Glu Ile Tyr Glu Leu Ser Tyr Ala 
             420                425                430
Arg Glu Pro Arg Asn His Arg Ala Pro Pro Leu Thr Pro Ser Lys Pro 
         435                440                445
Pro Val Val Val Asp Trp Ala Ser Gly Val Ser Pro Lys Pro Asp Pro 
     450                455                460
Lys Thr Ile Ser Lys His Val Gln Arg Met Val Asp Ser Val Phe Lys 
 465                470                475                480
Asn Tyr Asp Leu Asp Gln Asp Gly Tyr Ile Ser Gln Glu Glu Phe Glu 
                 485                490                495
Lys Ile Ala Ala Ser Phe Pro Phe Ser Phe Cys Val Met Asp Lys Asp 
             500                505                510
Arg Glu Gly Leu Ile Ser Arg Asp Glu Ile Thr Ala Tyr Phe Met Arg 
         515                520                525
Ala Ser Ser Ile Tyr Ser Lys Leu Gly Leu Gly Phe Pro His Asn Phe 
     530                535                540
Gln Glu Thr Thr Tyr Leu Lys Pro Thr Phe Cys Asp Asn Cys Ala Gly 
 545                550                555                560
Phe Leu Trp Gly Val Ile Lys Gln Gly Tyr Arg Cys Lys Asp Cys Gly 
                 565                570                575
Met Asn Cys His Lys Gln Cys Lys Asp Leu Val Val Phe Glu Cys Lys 
             580                585                590
Lys Arg Ser Lys Ser Pro Ala Val Ser Thr Glu Asn Ile Ser Ser Val 
         595                600                605
Val Pro Met Ser Thr Leu Cys Pro Leu Gly Thr Lys Asp Leu Leu His 
     610                615                620
Ala Pro Glu Glu Gly Ser Phe Ile Phe Gln Asn Gly Glu Val Val Asp 
 625                630                635                640
His Ser Glu Glu Ser Lys Asp Arg Thr Ile Met Leu Leu Gly Val Ser 
                 645                650                655
Ser Gln Lys Ile Ser Val Arg Leu Lys Arg Thr Val Ala His Lys Thr 
             660                665                670
Thr Gln Thr Glu Ser Phe Pro Trp Val Gly Gly Glu Met Pro Pro Gly 
         675                680                685
His Phe Val Leu Thr Ser Pro Arg Lys Ser Ala Gln Gly Ala Leu Tyr 
     690                695                700
Val His Ser Pro Ala Ser Pro Cys Pro Ser Pro Ala Leu Val Arg Lys 
 705                710                715                720
Arg Ala Phe Val Lys Trp Glu Asn Lys Glu Ser Leu Ile Lys Pro Lys 
                 725                730                735
Pro Glu Leu His Leu Arg Leu Arg Thr Tyr Gln Glu Leu Glu Gln Glu 
             740                745                750
Val Asn Thr Leu Arg Ala Asp Asn Asp Ala Leu Lys Ile Gln Leu Lys 
         755                760                765
Tyr Ala Gln Lys Gln Ile Glu Ser Leu Gln Leu Gly Lys Ser Asn His 
     770                775                780
Val Leu Ala Gln Met Asp His Gly Asp Gly Thr 
 785                790                795



<210> 1156
<211> 2139
<212> DNA
<213> Homo sapiens
<308> AF131853
<400> 1156

tgtgagttg  ccacgagga  acatgcata  gtatgagaa  atatacccc  tcctcagca  60
ttagcacag  gaattgaat  aagcagtac  aaggttttc  gttttaggt  tacctgatt  120
ccccttact  tactcaaat  catcccaat  cttctgtac  cttaaatca  ctgacaacc  180
ttaagcata  gctcttttg  taggtcttg  agaggaggc  caactgcct  catatgagt  240
cagtgtgtg  tgtcaaaat  taacttttg  attgttcta  agccacagt  agagaagta  300
gtggttcaa  tttcgtgcc  ttacatttc  accattgtg  tttcctctc  ctttacccc  360
catacaaaa  tgagccagg  aatgcctag  ttttgtgtg  tgaacacag  tgtacttac  420
tccaccatc  tctggacgt  tttgctaat  gtttttgga  caggtttgg  agacactcc  480
gaagcccag  ccactacta  tggtggctt  gaaggtgtt  gtggctaaa  tgaaatatt  540
agagaaatc  tcatgacta  aatgcaata  tataaccta  agctctttc  tttcccact  600
cctgacggt  acatttatg  acaatcttc  attatgttc  gtggcaagg  gcagagaac  660
cacaggcaa  tgaaatctc  actaataat  ttggctaac  aggcattgt  cttacggtt  720
ccagagtgc  cttcacata  attatctgc  gctacagat  atttgaaat  ctcaatctg  780
ctgagttgc  attccctct  cattaaacc  tttgtcaga  ctatcaaca  agagtaaag  840
ggatcattt  tgtttcctc  ctattctcc  gtcacattt  gcagtagaa  tgtgaataa  900
gaaaagctt  gctaaaagg  aggaaggca  aagaaaaat  atcggaagc  tggacaagc  960
cttttctaa  tacagtcat  catcactta  tgactggga  atgttctga  aaatgtgtc  1020
tgaggtgat  ttgtcattg  atgagcacc  cagtgtgta  ttacacaaa  ctagatggt  1080
tagcctgct  cacacctag  ctatttggt  tagcctact  ctcctaggc  acataccta  1140
acagcaggt  attatactc  gtactgtag  caattgtaa  gatggtatt  gtgtatctt  1200
acatatcta  acatagaaa  ggtaaaaat  tggtataga  atttttttt  aatgttaca  1260
ctgtatagg  cacttaacc  tgaatagag  tttcaagat  agaaattac  gtggcaagt  1320
gtgagtggt  agtgaatgt  gaggcctaa  attactgta  actcctata  actttataa  1380
tactgtaca  ttagactac  ctaagtttc  taaattttt  cttcaatga  aaattacct  1440
attttactg  aaaagcttt  aattttttt  acttttact  ttttgttat  acacttagc  1500
taaagcaca  attgtatag  ttatagctg  accagttat  tcctttata  ccatattct  1560
taaactttt  tctatttta  aaatgttta  ttttttaaa  ctttgttat  aactaaggt  1620
caattacac  cattggcct  tgtctatat  gagtcaaga  catcaatat  actgtcttc  1680
actccacat  ttgtcctat  ggaaggtct  taggggcaa  aacatgcat  gagctgtca  1740
cttctggag  acttgcctg  ggctgtttt  cagttaatt  ttctaagta  aaggaatgc  1800
ctctaaaat  atgataaaa  gtattgtat  gtaagtgca  aaaccggta  tacttacta  1860
caagtatta  gtactgtac  taagtgtat  acctagact  tttacagct  agtaggttt  1920
tttacacca  tataatcac  gacatagta  tgtgttgtg  tacaatgtt  caattgttc  1980
gtcactagg  agtagtaat  tttctgctc  attataatc  taagggacc  ctgtggtat  2040
tgaggtcta  cactgacca  aatgtcatt  tgtggtgca  gactgtatt  gaaactcag  2100
ccaaattaa  atctctctg  aaaaaaaaa  aaaaaaaaa  2139



<210> 1157
<211> 797
<212> PRT
<213> Homo sapiens
<308> AAC79699
<400> 1157

Met Gly Thr Leu Gly Lys Ala Arg Glu Ala Pro Arg Lys Pro Ser His 
  1               5                  10                  15
Gly Cys Arg Ala Ala Ser Lys Ala Arg Leu Glu Ala Lys Pro Ala Asn 
             20                  25                  30
Ser Pro Phe Pro Ser His Pro Ser Leu Ala His Ile Thr Gln Phe Arg 
         35                  40                  45
Met Met Val Ser Leu Gly His Leu Ala Lys Gly Ala Ser Leu Asp Asp 
     50                  55                  60
Leu Ile Asp Ser Cys Ile Gln Ser Phe Asp Ala Asp Gly Asn Leu Cys 
 65                  70                  75                  80
Arg Ser Asn Gln Leu Leu Gln Val Met Leu Thr Met His Arg Ile Val 
                 85                  90                  95
Ile Ser Ser Ala Glu Leu Leu Gln Lys Val Ile Thr Leu Tyr Lys Asp 
             100                105                110
Ala Leu Ala Lys Asn Ser Pro Gly Leu Cys Leu Lys Ile Cys Tyr Phe 
         115                120                125
Val Arg Tyr Trp Ile Thr Glu Phe Trp Val Met Phe Lys Met Asp Ala 
     130                135                140
Ser Leu Thr Asp Thr Met Glu Glu Phe Gln Glu Leu Val Lys Ala Lys 
 145                150                155                160
Gly Glu Glu Leu His Cys Arg Leu Ile Asp Thr Thr Gln Ile Asn Ala 
                 165                170                175
Arg Asp Trp Ser Arg Lys Leu Thr Gln Arg Ile Lys Ser Asn Thr Ser 
             180                185                190
Lys Lys Arg Lys Val Ser Leu Leu Phe Asp His Leu Glu Pro Glu Glu 
         195                200                205
Leu Ser Glu His Leu Thr Tyr Leu Glu Phe Lys Ser Phe Arg Arg Ile 
     210                215                220
Ser Phe Ser Asp Tyr Gln Asn Tyr Leu Val Asn Ser Cys Val Lys Glu 
 225                230                235                240
Asn Pro Thr Met Glu Arg Ser Ile Ala Leu Cys Asn Gly Ile Ser Gln 
                 245                250                255
Trp Val Gln Leu Met Val Leu Ser Arg Pro Thr Pro Gln Leu Arg Ala 
             260                265                270
Glu Val Phe Ile Lys Phe Ile Gln Val Ala Gln Lys Leu His Gln Leu 
         275                280                285
Gln Asn Phe Asn Thr Leu Met Ala Val Ile Gly Gly Leu Cys His Ser 
     290                295                300
Ser Ile Ser Arg Leu Lys Glu Thr Ser Ser His Val Pro His Glu Ile 
 305                310                315                320
Asn Lys Val Leu Gly Glu Met Thr Glu Leu Leu Ser Ser Ser Arg Asn 
                 325                330                335
Tyr Asp Asn Tyr Arg Arg Ala Tyr Gly Glu Cys Thr Asp Phe Lys Ile 
             340                345                350
Pro Ile Leu Gly Val His Leu Lys Asp Leu Ile Ser Leu Tyr Glu Ala 
         355                360                365
Met Pro Asp Tyr Leu Gly Asp Gly Lys Val Asn Val His Lys Leu Leu 
     370                375                380
Ala Leu Tyr Asn His Ile Ser Glu Leu Val Gln Leu Gln Glu Val Ala 
 385                390                395                400
Pro Pro Leu Glu Ala Asn Lys Asp Leu Val His Leu Leu Thr Leu Ser 
                 405                410                415
Leu Asp Leu Tyr Tyr Thr Glu Asp Glu Ile Tyr Glu Leu Ser Tyr Ala 
             420                425                430
Arg Glu Pro Arg Asn His Arg Ala Pro Pro Leu Thr Pro Ser Lys Pro 
         435                440                445
Pro Val Val Val Asp Trp Ala Ser Gly Val Ser Pro Lys Pro Asp Pro 
     450                455                460
Lys Thr Ile Ser Lys His Val Gln Arg Met Val Asp Ser Val Phe Lys 
 465                470                475                480
Asn Tyr Asp His Asp Gln Asp Gly Tyr Ile Ser Gln Glu Glu Phe Glu 
                 485                490                495
Lys Ile Ala Ala Ser Phe Pro Phe Ser Phe Cys Val Met Asp Lys Asp 
             500                505                510
Arg Glu Gly Leu Ile Ser Arg Asp Glu Ile Thr Ala Tyr Phe Met Arg 
         515                520                525
Ala Ser Ser Ile Tyr Ser Lys Leu Gly Leu Gly Phe Pro His Asn Phe 
     530                535                540
Gln Glu Thr Thr Tyr Leu Lys Pro Thr Phe Cys Asp Asn Cys Ala Gly 
 545                550                555                560
Phe Leu Trp Gly Val Ile Lys Gln Gly Tyr Arg Cys Lys Asp Cys Gly 
                 565                570                575
Met Asn Cys His Lys Gln Cys Lys Asp Leu Val Val Phe Glu Cys Lys 
             580                585                590
Lys Arg Ala Lys Asn Pro Val Ala Pro Thr Glu Asn Asn Thr Ser Val 
         595                600                605
Gly Pro Val Ser Asn Leu Cys Ser Leu Gly Ala Lys Asp Leu Leu His 
     610                615                620
Ala Pro Glu Glu Gly Pro Phe Thr Phe Pro Asn Gly Glu Ala Val Glu 
 625                630                635                640
His Gly Glu Glu Ser Lys Asp Arg Thr Ile Met Leu Met Gly Val Ser 
                 645                650                655
Ser Gln Lys Ile Ser Leu Arg Leu Lys Arg Ala Val Ala His Lys Ala 
             660                665                670
Thr Gln Thr Glu Ser Gln Pro Trp Ile Gly Ser Glu Gly Pro Ser Gly 
         675                680                685
Pro Phe Val Leu Ser Ser Pro Arg Lys Thr Ala Gln Asp Thr Leu Tyr 
     690                695                700
Val Leu Pro Ser Pro Thr Ser Pro Cys Pro Ser Pro Val Leu Val Arg 
 705                710                715                720
Lys Arg Ala Phe Val Lys Trp Glu Asn Lys Asp Ser Leu Ile Lys Ser 
                 725                730                735
Lys Glu Glu Leu Arg His Leu Arg Leu Pro Thr Tyr Gln Glu Leu Glu 
             740                745                750
Gln Glu Ile Asn Thr Leu Lys Ala Asp Asn Asp Ala Leu Lys Ile Gln 
         755                760                765
Leu Lys Tyr Ala Gln Lys Lys Ile Glu Ser Leu Gln Leu Glu Lys Ser 
     770                775                780
Asn His Val Leu Ala Gln Met Glu Gln Gly Asp Cys Ser 
 785                790                795



<210> 1158
<211> 1893
<212> DNA
<213> Rattus norvegicus
<308> AF081365
<400> 1158

caatcacac  actccactc  agttagcca  tgaaagcca  tgcaagtaa  tgtcattcc  60
aagcttaag  ttcattaag  tgggcctaa  agaagacag  tgctgtgca  acaacgtcg  120
acaagcacc  cttgcttgc  ttgcccagc  tgggcgctt  ggaacggag  gtgttcaga  180
tgctgatca  ggcactgac  gaaaggatg  tcaaacacc  ccgaagatg  tttatcact  240
acatatttg  gcgttcccg  caacgggca  ggctggtct  taaagaagg  agatgtaac  300
tcgagtttg  caatgtgga  gcacagtca  ggtttatat  ctttgtgga  atctggaca  360
ctgtgctgg  cctgaaatg  agagactca  gtgaccata  gttacggat  caggtttgt  420
acagaacag  gcgccactg  cattttcct  cttatcttc  agtctattc  tggagtgat  480
atcaattcc  tcatgtgtg  tgccatttt  gccaagatc  ctagaccca  aaaacgtgc  540
aaaaccatt  cgttcagca  gaatgcggt  atcagcaag  gtggcggga  gctctgcct  600
ctcatccga  tggccaatc  taggaagag  cttctgatt  gcagccaca  atatggcaa  660
cttctaaag  caaccatca  tcctgaagg  gagaccatc  ttttggatc  gaccaacat  720
aactttgtc  tcgacgctg  caatgaaaa  ttgttcttc  tatccccac  gacgatcta  780
cacattatt  accacaaca  ccctttctt  cacatggca  cagaaactc  ttcccaaca  840
gactttgag  tggtggtct  tttagatgg  acagtggaa  ccaccagtg  aacctgcca  900
gtccgcacg  catacgtcc  agaggaggt  ctttggggc  accgtttcg  tcctattgt  960
tccaagacc  aggaaggga  ataccgagt  gattttcat  acttcggta  gacagtgga  1020
gtggagacc  ctcactgtg  catgtgcct  tataatgag  aagatgcca  ggccaggat  1080
aagagaggc  atgacaacc  taactttgt  ttgtcagaa  ttgatgaaa  ggacgacac  1140
cagatgtag  agtggcttt  ccacctaca  aaagcctcc  aaggaccta  gggttgact  1200
tgttcagaa  catctgacg  gggtctgaa  gcaggatga  aacatgcga  atctgctag  1260
acagtcacc  ctgaacccc  gggctatgg  tctacaaga  acatagctc  ataaggctg  1320
atacggtgc  tgcatgtga  tgaaactgt  gaagccaaa  gggcccact  ggatcctca  1380
tatgactgt  taagctcat  tcgtgttga  ggaaacaaa  tcattcaag  acaaaactt  1440
ggagcttta  aaagcttca  gaactagcc  catttcctg  ttgattcta  ggatgagaa  1500
gatgccatt  ttatcttaa  gtagacttc  atcaatgga  aatctgccc  ctgcgctgg  1560
aagtgagcc  gccaatcag  gacaataag  gactgtcat  caaagaatc  gtaaagact  1620
taaccttct  aagctctgg  gtttgaagc  tttgtctga  tctgggtcc  tgcttcaga  1680
ggggtaagg  gacatccac  gactgtacc  ctctgaacc  aaggtacag  agaacagga  1740
gccccaatc  acttcataa  caacccaga  gctgcagcc  atacagaat  tggcctgaa  1800
gatttcctg  ggagcatta  atggaggcc  agtccactc  ttagatatt  aatgaatat  1860
cttttgcaa  ggaaaaaaa  aaaaaaaaa  aaa  1893



<210> 1159
<211> 391
<212> PRT
<213> Rattus norvegicus
<308> P35560
<400> 1159

Met Gly Ala Ser Glu Arg Ser Val Phe Arg Val Leu Ile Arg Ala Leu 
  1               5                  10                  15
Thr Glu Arg Met Phe Lys His Leu Arg Arg Trp Phe Ile Thr His Ile 
             20                  25                  30
Phe Gly Arg Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Glu Gly Arg 
         35                  40                  45
Cys Asn Ile Glu Phe Gly Asn Val Asp Ala Gln Ser Arg Phe Ile Phe 
     50                  55                  60
Phe Val Asp Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys 
 65                  70                  75                  80
Met Thr Val Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Leu Phe Gly 
                 85                  90                  95
Leu Leu Trp Tyr Val Val Ala Tyr Val His Lys Asp Leu Pro Glu Phe 
             100                105                110
Tyr Pro Pro Asp Asn Arg Thr Pro Cys Val Glu Asn Ile Asn Gly Met 
         115                120                125
Thr Ser Ala Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr 
     130                135                140
Gly Phe Arg Phe Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu 
 145                150                155                160
Ile Phe Gln Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly 
                 165                170                175
Ala Ile Leu Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile 
             180                185                190
Thr Phe Ser Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys 
         195                200                205
Leu Leu Ile Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser 
     210                215                220
His Ile Tyr Gly Lys Leu Leu Lys Thr Thr Ile Thr Pro Glu Gly Glu 
 225                230                235                240
Thr Ile Ile Leu Asp Gln Thr Asn Ile Asn Phe Val Val Asp Ala Gly 
                 245                250                255
Asn Glu Asn Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Ile Ile 
             260                265                270
Asp His Asn Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Ser Gln 
         275                280                285
Gln Asp Phe Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr 
     290                295                300
Ser Ala Thr Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu 
 305                310                315                320
Trp Gly Tyr Arg Phe Val Pro Ile Val Ser Lys Thr Lys Glu Gly Lys 
                 325                330                335
Tyr Arg Val Asp Phe His Asn Phe Gly Lys Thr Val Glu Val Glu Thr 
             340                345                350
Pro His Cys Ala Met Cys Leu Tyr Asn Glu Lys Asp Ala Arg Ala Arg 
         355                360                365
Met Lys Arg Gly Tyr Asp Asn Pro Asn Phe Val Leu Ser Glu Val Asp 
     370                375                380
Glu Thr Asp Asp Thr Gln Met 
 385                390



<210> 1160
<211> 2227
<212> DNA
<213> Homo sapiens
<308> NM_000220
<400> 1160

gaggcacta  agaaaaagt  gcagtaatg  aatccgctt  ttttgccaa  ccactaaaa  60
taccttggt  aatattagc  aatgtgcag  cctttgctt  ctattaaga  ttactgatt  120
caatagaaa  gaacctaaa  actgagcat  ttatataac  cagacacca  ggacaatct  180
taatcacct  agagttcat  aaatacata  tggctctgt  tgtggttag  ttaaatgcc  240
ttatctaaa  aaagtagga  ctgtgcaat  ataggtctg  catgtgaat  acagttttg  300
ttagtggat  aatttatcc  gtatcattg  attctctaa  aataatccc  ctcactctg  360
acaaataaa  caatagcat  ggctaaccc  gtgcatgta  aaaacacct  cagtaaatg  420
caggttttc  cgaataata  agacttcca  caataaaga  ttcttttaa  tctgtttct  480
acataactg  tgtatggag  gattaacat  gtatcttgt  tcttcctgg  gtgatctta  540
ttttgtctt  taaatatgt  cttatgtct  tatgttcac  tgtatcttt  tgaaccctt  600
gaaaactca  tatttcagt  ggtttcaga  aataggccg  gagattgat  ataagtaag  660
gtttccggc  agttgttat  aggcacaac  tttaggaga  acaagtgag  gatagagcg  720
ggccaagga  aggaaggca  tgctggaac  caatccacg  ctgctgccc  gagacctta  780
ctgatggct  gtcatgtct  agcatgttg  tattcaagc  atgtgatgt  ggaaagaaa  840
aatacctat  cagcttggg  cttggtctg  gaacaacca  ttgccttgg  ttaaatcac  900
cgactccac  atcaaatta  gtgtttcca  gtttacaca  attagcgtc  gtccactga  960
tgtcgccta  aataaatta  gctgagtct  aaagaaatc  gtctgcata  aaagaccaa  1020
aaccagcac  acttccttg  tttttccag  catgaatgc  tccagtcgg  atgtgtttg  1080
cacgttgat  agggtgttg  cagaaagta  gttcaaaca  cttcggaaa  gggtcgtca  1140
tcgcttttt  gggcattct  ggcaaagag  aaggctagt  tccaaagat  gaaggtgca  1200
catagaatt  ggcaatgtg  aggcacagt  aaggtttat  ttctttgtg  acatctgga  1260
aacggtact  gacctcaag  ggagataca  aatgaccat  ttcatcaca  ccttcttgg  1320
gagttggtt  ttctttggt  tcctgtggt  tgcagtagc  tacattcac  aagacctcc  1380
ggaattcca  ccttctgcc  atcacactc  ctgtgtgga  aatattaat  gcttgacct  1440
agcttttct  ttttctctg  agactcaag  gaccattgg  tatggattc  ggtgtgtga  1500
agaacagtg  gccactgcc  tttttctgc  tatctttca  tctatactt  gagttataa  1560
caattcttt  atgtgtggg  ccatcttag  caagatctc  aggcccaaa  aacgtgcca  1620
gaccattac  ttcagcaag  acgcagtga  cagcaaacg  ggagggaag  tttgcctcc  1680
aatccgagt  gctaatctc  ggaagagcc  tcttattgg  agtcacatt  atggaaagc  1740
tctgaagac  acagtcact  ctgaaggag  gaccattat  ttggaccag  tcaatatca  1800
ctttgtagt  gacgctggg  atgaaaatt  attcttcat  tccccattg  caatttacc  1860
tgtcattga  cacaacagc  ctttcttcc  catggcagc  gagaccctt  tccagcagg  1920
ctttgaatt  gtggtgttt  tagatggca  agtggagtc  accagtgct  cctgccaag  1980
ccggacatc  tatgtccca  aggaggtgc  ttggggcta  cgttttgct  ccatagtat  2040
caagacaaa  gaagggaaa  accgagtgg  tttccataa  tttagcaag  cagtggaag  2100
ggagacccc  cactgtgcc  tgtgccttt  taatgagaa  gatgttaga  ccaggatga  2160
gagaggcta  gacaacccc  acttcatct  gtcagaagt  aatgaaaca  atgacacca  2220
aatgtaa  2227



<210> 1161
<211> 391
<212> PRT
<213> Homo sapiens
<308> P48048
<400> 1161

Met Asn Ala Ser Ser Arg Asn Val Phe Asp Thr Leu Ile Arg Val Leu 
  1               5                  10                  15
Thr Glu Ser Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe 
             20                  25                  30
Phe Gly His Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg 
         35                  40                  45
Cys Asn Ile Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe 
     50                  55                  60
Phe Val Asp Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys 
 65                  70                  75                  80
Met Thr Ile Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly 
                 85                  90                  95
Leu Leu Trp Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe 
             100                105                110
His Pro Ser Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu 
         115                120                125
Thr Ser Ala Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr 
     130                135                140
Gly Phe Arg Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu 
 145                150                155                160
Ile Phe Gln Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly 
                 165                170                175
Ala Ile Leu Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile 
             180                185                190
Thr Phe Ser Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys 
         195                200                205
Leu Leu Ile Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser 
     210                215                220
His Ile Tyr Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu 
 225                230                235                240
Thr Ile Ile Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly 
                 245                250                255
Asn Glu Asn Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile 
             260                265                270
Asp His Asn Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln 
         275                280                285
Gln Asp Phe Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr 
     290                295                300
Ser Ala Thr Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu 
 305                310                315                320
Trp Gly Tyr Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys 
                 325                330                335
Tyr Arg Val Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr 
             340                345                350
Pro His Cys Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg 
         355                360                365
Met Lys Arg Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn 
     370                375                380
Glu Thr Asp Asp Thr Lys Met 
 385                390



<210> 1162
<211> 2473
<212> DNA
<213> Rattus norvegicus
<308> AF083330
<400> 1162

cgcccaagc  gcagagcgg  ccacctgga  ggacagagc  gcaagatgg  cagtaagac  60
aaggccagc  aggccctga  ggtggtggc  cggtgccgc  ccctcagta  gaaggagga  120
gctgctggt  atgagcaga  tctgaccat  gacgtgaaa  tgggccagg  gactctgcg  180
aacccccgc  cggcacccg  ggagctgcc  aagaccttc  cttttgatg  tgtgtatga  240
gctagctcc  agcaggccg  cctgtatga  gaaacggtg  ggcccctga  agactcggt  300
cttcagggt  tcaatggca  cgtatttgc  tatggccag  ctggcactg  caagaccta  360
accatgcag  ggacctggg  ggagccaga  ctccgcggg  ttatcccca  tgcctttga  420
cacatcttc  cccacattt  ccgctccca  aaccagcag  acctggttc  tgcctccta  480
ttggagatc  accaggagg  gattcgaga  ctgctatcc  aggagccag  caaaaggct  540
gaactgaag  agaatcctg  aacaggggt  tacatcaag  acctctctt  ctttgtcac  600
aagaatgtc  aggagattg  acacgtgat  aacctgggg  accaagccc  ggcagtagg  660
agcacccac  tgaatgagg  cagctcccg  tcccatgcc  tctttgtta  cacagtgga  720
tgcagtgag  gtggctccg  tggacagga  catatccga  taggcaagc  caacctggt  780
gacctggcc  gcagtgaga  gcagaacaa  gcaggtccc  acacacctg  agggccagc  840
acacagtca  cagctggtg  tggcggcgg  ggtggcggc  ctagtggtt  tggcagtag  900
ggagagagg  ctaaggaag  ttctaaaat  aatctttca  tgtccgccc  gggcaatgt  960
attgctgct  tggctggca  caggagcac  cacatcccc  accgggact  caagctgac  1020
cggctgctc  aagactcat  ggggggcaa  gccaagacc  tcatggtgg  cacactggg  1080
ccagcttct  atagctacg  cgacgagag  ctctccacc  tgcgctttg  gaaccgagc  1140
aagaacatc  agaacaaac  gcgggtgaa  gaggacccc  aggacacgc  gcttaggga  1200
ttccaggaa  agatcgccc  cttgaaggc  cagcttgag  agaagggga  gctgggaaa  1260
cgacctcgg  gaaagagca  tcgcagaaa  aaggccgtg  ctgctccgg  cggctatcc  1320
gagggggcc  taattgagg  ttgggtggc  gaagaggaa  atgataaca  caataatca  1380
cgcccaccc  agcccaccc  ggaggccgc  ttggagaaa  acatggaga  ttacctgca  1440
gaacagaaa  agcggctgg  ggaggagaa  gcggccatc  aggatgacc  cagcctcgt  1500
agtgaggag  agcagaagc  tctagaaga  aaggagaag  tgctggagg  tctgaagcg  1560
gagcagcag  ccacagagc  gcttgcagc  aagtacaag  ccatggaaa  caagctact  1620
attgggggg  ggaacatca  ggatcacac  aacgaacaa  agaagatgt  ggaactgaa  1680
cgacaggag  ttgcagaac  gaaacggcg  gaacgggaa  tgcagcagg  gatcgtgct  1740
cgagatgaa  agaccatgg  gctacgtgg  acctactcg  ccctgcagc  ggaggtgga  1800
gttaaaacc  agaaactca  gaagctcta  gccaagcta  aggcggtga  ggcagagat  1860
caggaccaa  atgaggagt  catccgcgt  cggcaggac  tggaggagg  gcagaatga  1920
cagacccgg  aactcaagc  caagtacct  atcattgag  acttcatcc  ccctgagga  1980
aagaacaag  tcatgaacc  gcttttcct  gactgtgag  aggagcagt  gaagttcca  2040
cccctggtg  cagctggag  gaataacag  caaatgaag  agcgtccaa  ttctgcagt  2100
ggctacaag  gacctatca  ccagtatgc  cgggttgcc  tggcaatgg  gtcccatcc  2160
agatacagg  ctgaaaata  aatgttttt  gaactggat  tatccccgc  ggccatctt  2220
gagatggaa  tttctcatg  ccaagaaca  gatccacga  tactacaca  ggagaggct  2280
atgcggttg  acagctttc  ggagagacc  tccacgtct  aagtgcgaa  gtcgagatc  2340
tggtgccag  gtcctcagc  gcctccacc  ccctccaca  ttcatgcct  catggcctc  2400
gctcctctg  accctgcaa  agtggtaga  catgactga  accttagtc  ggctgccat  2460
acaaagact  tag  2473



<210> 1163
<211> 796
<212> PRT
<213> Rattus norvegicus
<308> O55165
<400> 1163

Met Ala Ser Lys Thr Lys Ala Ser Glu Ala Leu Lys Val Val Ala Arg 
  1               5                  10                  15
Cys Arg Pro Leu Ser Arg Lys Glu Glu Ala Ala Gly His Glu Gln Ile 
             20                  25                  30
Leu Thr Met Asp Val Lys Leu Gly Gln Val Thr Leu Arg Asn Pro Arg 
         35                  40                  45
Ala Ala Pro Gly Glu Leu Pro Lys Thr Phe Thr Phe Asp Ala Val Tyr 
     50                  55                  60
Asp Ala Ser Ser Lys Gln Ala Asp Leu Tyr Asp Glu Thr Val Arg Pro 
 65                  70                  75                  80
Leu Ile Asp Ser Val Leu Gln Gly Phe Asn Gly Thr Val Phe Ala Tyr 
                 85                  90                  95
Gly Gln Thr Gly Thr Gly Lys Thr Tyr Thr Met Gln Gly Thr Trp Val 
             100                105                110
Glu Pro Glu Leu Arg Gly Val Ile Pro Asn Ala Phe Glu His Ile Phe 
         115                120                125
Thr His Ile Ser Arg Ser Gln Asn Gln Gln Tyr Leu Val Arg Ala Ser 
     130                135                140
Tyr Leu Glu Ile Tyr Gln Glu Glu Ile Arg Asp Leu Leu Ser Lys Glu 
 145                150                155                160
Pro Gly Lys Arg Leu Glu Leu Lys Glu Asn Pro Glu Thr Gly Val Tyr 
                 165                170                175
Ile Lys Asp Leu Ser Ser Phe Val Thr Lys Asn Val Lys Glu Ile Glu 
             180                185                190
His Val Met Asn Leu Gly Asn Gln Ala Arg Ala Val Gly Ser Thr His 
         195                200                205
Met Asn Glu Val Ser Ser Arg Ser His Ala Ile Phe Val Ile Thr Val 
     210                215                220
Glu Cys Ser Glu Arg Gly Ser Asp Gly Gln Asp His Ile Arg Val Gly 
 225                230                235                240
Lys Leu Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Gln Asn Lys Ala 
                 245                250                255
Gly Pro Asn Thr Pro Gly Gly Pro Ala Thr Gln Ser Thr Ala Gly Gly 
             260                265                270
Gly Gly Gly Gly Gly Gly Thr Ser Gly Ser Gly Ser Ser Gly Glu Arg 
         275                280                285
Pro Lys Glu Ala Ser Lys Ile Asn Leu Ser Leu Ser Ala Leu Gly Asn 
     290                295                300
Val Ile Ala Ala Leu Ala Gly Asn Arg Ser Thr His Ile Pro Tyr Arg 
 305                310                315                320
Asp Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser Leu Gly Gly Asn Ala 
                 325                330                335
Lys Thr Ile Met Val Ala Thr Leu Gly Pro Ala Ser His Ser Tyr Asp 
             340                345                350
Glu Ser Leu Ser Thr Leu Arg Phe Ala Asn Arg Ala Lys Asn Ile Lys 
         355                360                365
Asn Lys Pro Arg Val Asn Glu Asp Pro Lys Asp Thr Leu Leu Arg Glu 
     370                375                380
Phe Gln Glu Glu Ile Ala Arg Leu Lys Ala Gln Leu Glu Lys Lys Gly 
 385                390                395                400
Met Leu Gly Lys Arg Pro Arg Arg Lys Ser Ser Arg Arg Lys Lys Ala 
                 405                410                415
Val Ser Ala Pro Ala Gly Tyr Pro Glu Gly Ala Val Ile Glu Ala Trp 
             420                425                430
Val Ala Glu Glu Glu Asp Asp Asn Asn Asn Asn His Arg Pro Pro Gln 
         435                440                445
Pro Thr Leu Glu Ala Ala Leu Glu Lys Asn Met Glu Asn Tyr Leu Gln 
     450                455                460
Glu Gln Lys Glu Arg Leu Glu Glu Glu Lys Ala Ala Ile Gln Asp Asp 
 465                470                475                480
Arg Ser Leu Val Ser Glu Glu Lys Gln Lys Leu Leu Glu Glu Lys Glu 
                 485                490                495
Lys Met Leu Glu Asp Leu Lys Arg Glu Gln Gln Ala Thr Glu Leu Leu 
             500                505                510
Ala Ala Lys Tyr Lys Ala Met Glu Ser Lys Leu Leu Ile Gly Gly Arg 
         515                520                525
Asn Ile Met Asp His Thr Asn Glu Gln Gln Lys Met Leu Glu Leu Lys 
     530                535                540
Arg Gln Glu Ile Ala Glu Gln Lys Arg Arg Glu Arg Glu Met Gln Gln 
 545                550                555                560
Glu Met Leu Leu Arg Asp Glu Glu Thr Met Glu Leu Arg Gly Thr Tyr 
                 565                570                575
Ser Ser Leu Gln Gln Glu Val Glu Val Lys Thr Lys Lys Leu Lys Lys 
             580                585                590
Leu Tyr Ala Lys Leu Gln Ala Val Lys Ala Glu Ile Gln Asp Gln His 
         595                600                605
Glu Glu Tyr Ile Arg Val Arg Gln Asp Leu Glu Glu Ala Gln Asn Glu 
     610                615                620
Gln Thr Arg Glu Leu Lys Leu Lys Tyr Leu Ile Ile Glu Asn Phe Ile 
 625                630                635                640
Pro Pro Glu Glu Lys Asn Lys Ile Met Asn Arg Leu Phe Leu Asp Cys 
                 645                650                655
Glu Glu Glu Gln Trp Lys Phe Gln Pro Leu Val Pro Ala Gly Val Asn 
             660                665                670
Asn Ser Gln Met Lys Lys Arg Pro Thr Ser Ala Val Gly Tyr Lys Arg 
         675                680                685
Pro Ile Ser Gln Tyr Ala Arg Val Ala Met Ala Met Gly Ser His Pro 
     690                695                700
Arg Tyr Arg Ala Glu Asn Ile Met Phe Leu Glu Leu Asp Val Ser Pro 
 705                710                715                720
Pro Ala Ile Phe Glu Met Glu Phe Ser His Asp Gln Glu Gln Asp Pro 
                 725                730                735
Arg Val Leu His Met Glu Arg Leu Met Arg Leu Asp Ser Phe Leu Glu 
             740                745                750
Arg Pro Ser Thr Ser Lys Val Arg Lys Ser Arg Ser Trp Cys Gln Ser 
         755                760                765
Pro Gln Arg Pro Pro Pro Pro Ser Thr Val His Ala Ser Met Ala Ser 
     770                775                780
Ala Pro Leu His Pro Ala Thr Val Val Asp His Asp 
 785                790                795



<210> 1164
<211> 7420
<212> DNA
<213> Rattus norvegicus
<308> AF084186
<400> 1164

atggatcca  gtggggtca  agtgctgga  acagccgag  acatccagg  gagacgaca  60
caggttctg  atcggtacc  ccgcttcaa  gagctctct  ccttgcggc  gcagaaact  120
gaggattcc  atcgcttcc  gttttttca  agagatgct  aggagctgg  gaagtggat  180
caggagaag  ttcaagttg  ctctgatga  aactacaaa  accccacca  cttgcaggg  240
aagctccag  aacaccaag  ctttgaagc  gaagtacag  ccaactcag  agccattgt  300
aagctggat  agacaggaa  cttgatgat  tctgaaggg  actttgcat  tgagaccat  360
cggacacgt  taatggagc  gcaccgcca  tgggagttg  ttttggaga  gatgcggga  420
aaaggaatc  aactgctgc  ggcacagaa  ctggtgcag  atttgcggg  gtgtgagga  480
gtaatggac  ggatcaatg  caaggaagc  attgtgacg  ctgaggagc  gggccagga  540
ttggagcat  tagaggtac  acagaagaa  tttgaagag  ttcaaactg  tctggctgc  600
catgaagaa  gagttaatg  agtaaacca  tttgctgcc  aacttatcc  ggagcagca  660
ccggaagag  agctgatca  gaccaagca  gaggaggtg  atgcagctt  gcagcgact  720
aaaggcctg  ctcttcaaa  gcaggggaa  ctctttggt  ctgccgagg  tcagcgctt  780
aacagggat  tagatgaga  cattggttg  attaaggag  aagagcagt  aatggcctc  840
gatgacttt  gcagagact  agcaagtgt  caagctctg  ttcggaagc  tgagggtct  900
gagagagat  ttgctgctc  agaggacaa  gtgaaagcc  tgtgtgccg  ggctgaccg  960
ctgcaacag  cacaccctc  gagtgccaa  cagatccag  tgaagcgag  ggaactaat  1020
accaactgg  agcagatcc  aactctggc  gcagagaga  atgcacggc  tgatgactc  1080
tacaggctt  agcgctttc  tgctgactt  cgtgacctc  cgagctggg  gactgaaat  1140
aaagccctc  tcaatgcag  cgagcttgc  aatgacgtg  ctggtgctg  ggccctgct  1200
gacaggcat  aagagcaca  gggtgaaat  gatgctcat  aagatagct  taagtctgc  1260
gatgagtct  ggcaggccc  actcgctgc  ggtcactat  cctcagatg  agtgaggga  1320
aagctgagc  tcctctctg  ggagagagc  gccctgctg  agctgtggg  gcttcggag  1380
cagcagtat  agcagtgca  ggacttgca  ctcttctac  gagacactg  gcaggtgga  1440
aactggatg  gcaaacagg  ggcattcct  ctaaatgaa  atttgggtg  ctccttaga  1500
agtgtggaa  ctcttttga  gaagcatga  gactttgag  aatctctca  tgcccagga  1560
gaaaaaatc  cagcacttg  tgagtttgc  accaagctt  ttcagaaca  ccactacgc  1620
atggaagat  tagccactc  acgagatgc  ctcctgagc  gccgcaatg  cctccatga  1680
cgagccatg  atcgccggg  acagctggc  gattccttc  acctgcagc  gttcttccg  1740
gattccgat  agctcaaaa  ttgggtcaa  gagaagatg  aaacggcca  tgatgaagc  1800
tacaaagat  cgtccaacc  gcaagggaa  gtccaaaag  accaggctt  tgaggctga  1860
ctctcagcc  accagagcc  tattgatgc  ctagagaaa  ctgggcaaa  actaataga  1920
gtgaaccac  atgccaagg  agaagtagc  gctcggatg  atgaggtca  cagtttgtg  1980
aagaaactt  tagaggcca  agaactgaa  ggagtcaag  tccgagaag  caaccagca  2040
caacaattt  atcgcaatg  tgaggacat  gagttgtgg  tgtatgaag  tgaaggtca  2100
ttggcttca  atgattatg  taaagacct  actaatgtc  agaacctcc  gaagaagca  2160
gctctgcta  aggcagatg  tgctgctca  caggatcga  ttgacggca  cacaattca  2220
gcccgccag  tccaagatg  tggccattt  gatgccgaa  acattaaaa  gaagcaaga  2280
gcccttgta  ctcgctatg  ggctctcaa  gaacccatg  tggcccgga  gcagaagct  2340
gcagattct  ttcgtctgc  gcagctctt  cgagatgtg  aggatgagg  aacctggat  2400
cgagaaaag  agcctattg  tgcgtccac  aacagaggc  aagatctta  tggagtcca  2460
aatctgcta  agaagcacc  agctttaca  gcagaaatt  ctggccatg  acctcgcat  2520
aaagcagtg  cacaaaagg  caatgccat  gtggaggaa  gccattttg  tgctgagga  2580
gtgaaggcc  aactgagtg  gctcaacca  aagtgggag  cactgaaag  caaagcctc  2640
cagcggagg  aggatctgg  ggactcact  caggcccag  agtactttg  cgacgccaa  2700
gaagctgag  cctggatgc  ggagaagga  cccattgtg  gcagtaccg  ctatgggaa  2760
gatgaagac  ctgctgagg  tctgctcaa  aagcatgaa  ctttgatgt  cgatctcag  2820
gcctacggc  gcagcattc  agctttgcg  gagcaggct  agtcatgcc  gcaacaagt  2880
gcccccatg  atgatgaga  tggcaagga  ctggtcttg  ctctctatg  ctatcaaga  2940
aagagccct  gtgaggtca  catgaagaa  ggggatatc  tcaccttgc  caacagcac  3000
aacaaggac  ggtggaaag  ggaagtgaa  gaccgtcag  gttttgtgc  agctgcgta  3060
gtgaagaag  tggaccccg  ccagtcagc  tcaagggag  acctcctgg  agaacaggg  3120
agcattgct  tgcggcagg  gcagatcga  aaccagaca  gcataacta  ggaggccgg  3180
agtgtatct  tgcgtatga  acaggtgga  gaactgtat  agtctctgc  ggagctggg  3240
gagaagaga  aaggcatgt  ggagaagag  tgcaagaag  tcatgttgt  ccgggaagc  3300
aacgagcta  agcagtgga  caacgagaa  gaagctgct  taacgagtg  agaggttgg  3360
gctgacttg  agcaggtcg  ggtgctgca  aagaagttc  atgacttcc  gaaggatct  3420
aaagccaat  agtcccggc  gaaggacat  aacaaagtg  ccgaggacc  ggagtctga  3480
ggtctcatg  cggaagaag  gcaggccgt  cagcagcag  aggtgtatg  tatgatgcc  3540
agggatgaa  cagattcca  gaccgcctc  ccatggaag  ctgctcgac  gatggtcca  3600
acagtggcc  ccttcaact  catcaagga  ctgaatgag  gctggcggt  cctgcaaca  3660
ctggctgag  aacgtagcc  gctcctggg  agtgcacac  aagtacaga  gttccacag  3720
gatgcggat  aaaccaaag  atggattga  gagaagaac  aggctctga  cacagacaa  3780
tatggccat  atctagcta  cgtccaggc  ctgcagcgc  aacacgaag  cttcgagag  3840
gaccttgca  ctcttggtg  caaggtgaa  tcccttggg  aaacagccc  gaggctgat  3900
cagtcccac  ctgaatctg  agaggactt  aaggaaaag  gcacagagt  aaaccaggc  3960
tggaccagc  tagggaagc  tgcagacca  cgcaaggcc  aactgggtg  ctcccatga  4020
ctgcagcgc  tccttagcg  tttccggga  ctcatgtct  ggatcaatg  aatacgagg  4080
ttggtatct  cagatgaac  ggccaagga  gtcactgga  ctgaggctt  gctggagcg  4140
caccaggaa  accggacag  aattgatgc  agggctggc  ctttccagg  atttgagca  4200
tttgggcag  agctgttgg  tcatgggca  tatgccagc  cagagatca  ggagaaact  4260
gatattctt  accaggagc  cacagacct  gagaaggcc  gggttcagc  cagaatgat  4320
ctggaccac  gcctggagt  gcagctgtt  catcgagac  gtgagcaag  agagaactg  4380
atggctgcc  gggaagcct  cctaaacac  gaagacaaa  gagactcgc  ggacagtgt  4440
gaggctctg  tcaaaaaac  tgaagactt  gacaaagct  tcaatgtcc  ggaggagaa  4500
atagctgcc  tgcaggcct  tgccgacca  ctcattgct  tggaccact  tgccaaggg  4560
gacattgca  accgacgca  tgaggtcct  gacaggtgg  gccgcctaa  agcccagat  4620
attgagaaa  ggtcaaagc  cggagaatc  caaacactt  agcagttca  ccgggatgt  4680
gatgagatt  aagcctgga  cagtgagaa  ttacaaaca  ccagcgatg  gtcatacaa  4740
gaccccacc  acatccaga  caagcacca  aagcaccaa  cctttgagg  agaactgca  4800
gccaatgct  accgaatcc  tggagttat  gacatgggc  actccctca  tgagcgtgg  4860
gcctgtgct  gcagtgagg  tgctgtcaa  gcccgcctg  ctgcccttg  agaccagtg  4920
cagttcctg  tgcagaagt  agctgagaa  agccagaag  tgaaagagg  caataagca  4980
cagaacttc  acaccggga  caaagactt  gacttctgg  tttctgagg  ggaggctct  5040
ctggcatct  aagactacg  caaagacct  gcttccgtg  acaacctgc  caaaaagca  5100
cagctgctg  aggcagaca  atcggccca  gaggatcgt  tgaaggacc  gaacagcca  5160
gctgacagc  tgatgacta  cagtgcctt  gacacctcc  aagtgaaag  gaagcggga  5220
accatcaat  gacgctttc  gaagatcaa  agcatggca  cctcccgaa  agcaaaact  5280
agcgagtcc  atcgcctgc  ccagttttt  cgagacatg  atgacgagg  gtcctggat  5340
aaggagaag  agttgttag  gagctctga  gactatggc  gagacctca  tggtgttca  5400
aatctgagg  agaaacaca  gcggctaga  gccgaactg  ccgcacacg  accagccat  5460
cagggtgtc  tggacacgg  gaagaagct  tctgatgac  acaccatcg  gcaggagga  5520
atccagcag  gtctcgcac  gtttgtgga  cactggaag  aactgaaac  gctagcagc  5580
gcacggggc  agcggctgg  ggagtcctt  gagtatcag  agtttgtgg  caacgtgga  5640
gaggaggag  cttggatca  tgagaagat  accctggtg  ccagcgaag  ctacgggga  5700
actcttgct  ccatccagg  cttactgaa  aaacatgaa  cttttgaga  agacttcac  5760
gtccacaag  atcgagtga  tgatgtctg  actaatgga  aagacctca  taagaagaa  5820
aatcaccat  aggagaaca  ctcttcaaa  atgaagggt  tgaatggta  agtgtctga  5880
ctggagaaa  cagcagctc  gaggaaagc  aagctggat  agaactcgg  cttccttca  5940
ttcaattgg  aggctgacg  ggtggagtc  tggattggt  aaaaggaga  cagcttgaa  6000
acagatgat  atggccgag  tctgtcttc  gtccaaact  tgctcacca  gcaggagac  6060
tttgatgct  gcctgcagg  cttccagca  gagggcatt  ccaatatca  tgccctcaa  6120
gaccagctg  tagctgcca  gcacattca  tcgaaggcc  tcgaggccc  acatgcctc  6180
ctcatgaag  ggtggaccc  gctgttggc  aattcagct  cccgcaaga  gaagttgct  6240
gaggcccag  gtcatttcc  aaaggtaga  gacctcttc  tgacctttg  caaaaaggc  6300
tcggctttc  acagctggt  tgagaatgc  gaagaggac  tcacagacc  agtgcgctg  6360
aactctctg  aagaaatca  agccctccg  gaggctcat  atgccttcc  ctcatcgct  6420
agctctgcg  aggccgact  caaccagct  gccgagctg  accgtcaga  caagagttt  6480
cgagtggcc  ccaatccct  cacctggtt  accatggag  ccctggaag  gacgtggag  6540
aacctacag  agatcatta  ggagcgaga  ctggagctg  agaaggaac  gcggcggca  6600
gaggagaat  acaagctac  ccaagagtt  gcccagcat  ccaacgcgt  ccaccagtg  6660
atccaggaa  caagaacgt  tctcctcga  gggtcctgc  tggtcgaag  gtcgggaac  6720
ctggaatct  agcttgaag  taccaaacg  aagcaccag  agattcggg  catgagaag  6780
cagctgaag  agattgagg  cctgggggc  gccatggag  aagccctca  cctggacaa  6840
aagtacact  agcacagca  tgtgggcct  gcccagcag  gggaccagt  agaccagct  6900
ggcatgcgc  tgcagcaca  cctggagca  cagatccag  ccaggaaca  aacaggagt  6960
actgaggag  ccctcaagg  gttcagcat  atgttcaaa  acttcgaca  ggacaagtc  7020
ggccggctg  atcatcaag  gttcaaatc  tgccttcgt  ctctgggtt  cgacctgcc  7080
atggttgag  aaggagagc  tgatcctga  tttgaggcc  tactggaca  tgttgatcc  7140
aacagggac  gccacgtct  cctgcaaga  tacatggct  tcatgatca  ccgtgaaac  7200
gagaatgtc  agtccagtg  agagatcga  agtgctttc  gggccctca  ctccgaggg  7260
aagccttat  tgaccaagg  ggagctcta  cagaacctg  cccgggaac  agctgacta  7320
tgtgtctcc  acatgaagc  ctatgtgga  ggcaagggc  gcgaacttc  aactgcctt  7380
gactacgtg  agttcaccc  ctctctctt  gtgaattgat  7420



<210> 1165
<211> 2472
<212> PRT
<213> Rattus norvegicus
<308> P16086
<400> 1165

Met Asp Pro Ser Gly Val Lys Val Leu Glu Thr Ala Glu Asp Ile Gln 
  1               5                  10                  15
Glu Arg Arg Gln Gln Val Leu Asp Arg Tyr His Arg Phe Lys Glu Leu 
             20                  25                  30
Ser Thr Leu Arg Arg Gln Lys Leu Glu Asp Ser Tyr Arg Phe Gln Phe 
         35                  40                  45
Phe Gln Arg Asp Ala Glu Glu Leu Glu Lys Trp Ile Gln Glu Lys Leu 
     50                  55                  60
Gln Val Ala Ser Asp Glu Asn Tyr Lys Asp Pro Thr Asn Leu Gln Gly 
 65                  70                  75                  80
Lys Leu Gln Lys His Gln Ala Phe Glu Ala Glu Val Gln Ala Asn Ser 
                 85                  90                  95
Gly Ala Ile Val Lys Leu Asp Glu Thr Gly Asn Leu Met Ile Ser Glu 
             100                105                110
Gly His Phe Ala Ser Glu Thr Ile Arg Thr Arg Leu Met Glu Leu His 
         115                120                125
Arg Gln Trp Glu Leu Leu Leu Glu Lys Met Arg Glu Lys Gly Ile Lys 
     130                135                140
Leu Leu Gln Ala Gln Lys Leu Val Gln Tyr Leu Arg Glu Cys Glu Asp 
 145                150                155                160
Val Met Asp Trp Ile Asn Asp Lys Glu Ala Ile Val Thr Ser Glu Glu 
                 165                170                175
Leu Gly Gln Asp Leu Glu His Val Glu Val Leu Gln Lys Lys Phe Glu 
             180                185                190
Glu Phe Gln Thr Asp Leu Ala Ala His Glu Glu Arg Val Asn Glu Val 
         195                200                205
Asn Gln Phe Ala Ala Lys Leu Ile Gln Glu Gln His Pro Glu Glu Glu 
     210                215                220
Leu Ile Lys Thr Lys Gln Glu Glu Val Asn Ala Ala Trp Gln Arg Leu 
 225                230                235                240
Lys Gly Leu Ala Leu Gln Arg Gln Gly Lys Leu Phe Gly Ala Ala Glu 
                 245                250                255
Val Gln Arg Phe Asn Arg Asp Val Asp Glu Thr Ile Gly Trp Ile Lys 
             260                265                270
Glu Lys Glu Gln Leu Met Ala Ser Asp Asp Phe Gly Arg Asp Leu Ala 
         275                280                285
Ser Val Gln Ala Leu Leu Arg Lys His Glu Gly Leu Glu Arg Asp Leu 
     290                295                300
Ala Ala Leu Glu Asp Lys Val Lys Ala Leu Cys Ala Glu Ala Asp Arg 
 305                310                315                320
Leu Gln Gln Ser His Pro Leu Ser Ala Asn Gln Ile Gln Val Lys Arg 
                 325                330                335
Glu Glu Leu Ile Thr Asn Trp Glu Gln Ile Arg Thr Leu Ala Ala Glu 
             340                345                350
Arg His Ala Arg Leu Asp Asp Ser Tyr Arg Leu Gln Arg Phe Leu Ala 
         355                360                365
Asp Phe Arg Asp Leu Thr Ser Trp Val Thr Glu Met Lys Ala Leu Ile 
     370                375                380
Asn Ala Asp Glu Leu Ala Asn Asp Val Ala Gly Ala Glu Ala Leu Leu 
 385                390                395                400
Asp Arg His Gln Glu His Lys Gly Glu Ile Asp Ala His Glu Asp Ser 
                 405                410                415
Phe Lys Ser Ala Asp Glu Ser Gly Gln Ala Leu Leu Ala Ala Gly His 
             420                425                430
Tyr Ala Ser Asp Glu Val Arg Glu Lys Leu Ser Ile Leu Ser Glu Glu 
         435                440                445
Arg Ala Ala Leu Leu Glu Leu Trp Glu Leu Arg Arg Gln Gln Tyr Glu 
     450                455                460
Gln Cys Met Asp Leu Gln Leu Phe Tyr Arg Asp Thr Glu Gln Val Asp 
 465                470                475                480
Asn Trp Met Ser Lys Gln Glu Ala Phe Leu Leu Asn Glu Asp Leu Gly 
                 485                490                495
Asp Ser Leu Asp Ser Val Glu Ala Leu Leu Lys Lys His Glu Asp Phe 
             500                505                510
Glu Lys Ser Leu Ser Ala Gln Glu Glu Lys Ile Thr Ala Leu Asp Glu 
         515                520                525
Phe Ala Thr Lys Leu Ile Gln Asn Asn His Tyr Ala Met Glu Asp Val 
     530                535                540
Ala Thr Arg Arg Asp Ala Leu Leu Ser Arg Arg Asn Ala Leu His Glu 
 545                550                555                560
Arg Ala Met His Arg Arg Ala Gln Leu Ala Asp Ser Phe His Leu Gln 
                 565                570                575
Gln Phe Phe Arg Asp Ser Asp Glu Leu Lys Ser Trp Val Asn Glu Lys 
             580                585                590
Met Lys Thr Ala Thr Asp Glu Ala Tyr Lys Asp Pro Ser Asn Leu Gln 
         595                600                605
Gly Lys Val Gln Lys His Gln Ala Phe Glu Ala Glu Leu Ser Ala Asn 
     610                615                620
Gln Ser Arg Ile Asp Ala Leu Glu Lys Ala Gly Gln Lys Leu Ile Asp 
 625                630                635                640
Val Asn His Tyr Ala Lys Glu Glu Val Ala Ala Arg Met Asn Glu Val 
                 645                650                655
Ile Ser Leu Trp Lys Lys Leu Leu Glu Ala Thr Glu Leu Lys Gly Val 
             660                665                670
Lys Leu Arg Glu Ala Asn Gln Gln Gln Gln Phe Asn Arg Asn Val Glu 
         675                680                685
Asp Ile Glu Leu Trp Leu Tyr Glu Val Glu Gly His Leu Ala Ser Asp 
     690                695                700
Asp Tyr Gly Lys Asp Leu Thr Asn Val Gln Asn Leu Gln Lys Lys His 
 705                710                715                720
Ala Leu Leu Glu Ala Asp Val Ala Ala His Gln Asp Arg Ile Asp Gly 
                 725                730                735
Ile Thr Ile Gln Ala Arg Gln Phe Gln Asp Ala Gly His Phe Asp Ala 
             740                745                750
Glu Asn Ile Lys Lys Lys Gln Glu Ala Leu Val Ala Arg Tyr Glu Ala 
         755                760                765
Leu Lys Glu Pro Met Val Ala Arg Lys Gln Lys Leu Ala Asp Ser Leu 
     770                775                780
Arg Leu Gln Gln Leu Phe Arg Asp Val Glu Asp Glu Glu Thr Trp Ile 
 785                790                795                800
Arg Glu Lys Glu Pro Ile Ala Ala Ser Thr Asn Arg Gly Lys Asp Leu 
                 805                810                815
Ile Gly Val Gln Asn Leu Leu Lys Lys His Gln Ala Leu Gln Ala Glu 
             820                825                830
Ile Ala Gly His Glu Pro Arg Ile Lys Ala Val Thr Gln Lys Gly Asn 
         835                840                845
Ala Met Val Glu Glu Gly His Phe Ala Ala Glu Asp Val Lys Ala Lys 
     850                855                860
Leu Ser Glu Leu Asn Gln Lys Trp Glu Ala Leu Lys Ala Lys Ala Ser 
 865                870                875                880
Gln Arg Arg Gln Asp Leu Glu Asp Ser Leu Gln Ala Gln Gln Tyr Phe 
                 885                890                895
Ala Asp Ala Asn Glu Ala Glu Ser Trp Met Arg Glu Lys Glu Pro Ile 
             900                905                910
Val Gly Ser Thr Asp Tyr Gly Lys Asp Glu Asp Ser Ala Glu Ala Leu 
         915                920                925
Leu Lys Lys His Glu Ala Leu Met Ser Asp Leu Ser Ala Tyr Gly Ser 
     930                935                940
Ser Ile Gln Ala Leu Arg Glu Gln Ala Gln Ser Cys Arg Gln Gln Val 
 945                950                955                960
Ala Pro Met Asp Asp Glu Thr Gly Lys Glu Leu Val Leu Ala Leu Tyr 
                 965                970                975
Asp Tyr Gln Glu Lys Ser Pro Arg Glu Val Thr Met Lys Lys Gly Asp 
             980                985                990
Ile Leu Thr Leu Leu Asn Ser Thr Asn Lys Asp Trp Trp Lys Val Glu 
         995                1000                1005
Val Asn Asp Arg Gln Gly Phe Val Pro Ala Ala Tyr Val Lys Lys Leu 
     1010                1015                1020
Asp Pro Ala Gln Ser Ala Ser Arg Glu Asn Leu Leu Glu Glu Gln Gly 
 1025                1030                1035                1040
Ser Ile Ala Leu Arg Gln Gly Gln Ile Asp Asn Gln Thr Arg Ile Thr 
                 1045                1050                1055
Lys Glu Ala Gly Ser Val Ser Leu Arg Met Lys Gln Val Glu Glu Leu 
             1060                1065                1070
Tyr Gln Ser Leu Leu Glu Leu Gly Glu Lys Arg Lys Gly Met Leu Glu 
         1075                1080                1085
Lys Ser Cys Lys Lys Phe Met Leu Phe Arg Glu Ala Asn Glu Leu Gln 
     1090                1095                1100
Gln Trp Ile Asn Glu Lys Glu Ala Ala Leu Thr Ser Glu Glu Val Gly 
 1105                1110                1115                1120
Ala Asp Leu Glu Gln Val Glu Val Leu Gln Lys Lys Phe Asp Asp Phe 
                 1125                1130                1135
Gln Lys Asp Leu Lys Ala Asn Glu Ser Arg Leu Lys Asp Ile Asn Lys 
             1140                1145                1150
Val Ala Glu Asp Leu Glu Ser Glu Gly Leu Met Ala Glu Glu Val Gln 
         1155                1160                1165
Ala Val Gln Gln Gln Glu Val Tyr Gly Met Met Pro Arg Asp Glu Ala 
     1170                1175                1180
Asp Ser Lys Thr Ala Ser Pro Trp Lys Ser Ala Arg Leu Met Val His 
 1185                1190                1195                1200
Thr Val Ala Thr Phe Asn Ser Ile Lys Glu Leu Asn Glu Arg Trp Arg 
                 1205                1210                1215
Ser Leu Gln Gln Leu Ala Glu Glu Arg Ser Gln Leu Leu Gly Ser Ala 
             1220                1225                1230
His Glu Val Gln Arg Phe His Arg Asp Ala Asp Glu Thr Lys Glu Trp 
         1235                1240                1245
Ile Glu Glu Lys Asn Gln Ala Leu Asn Thr Asp Asn Tyr Gly His Asp 
     1250                1255                1260
Leu Ala Ser Val Gln Ala Leu Gln Arg Lys His Glu Gly Phe Glu Arg 
 1265                1270                1275                1280
Asp Leu Ala Ala Leu Gly Asp Lys Val Asn Ser Leu Gly Glu Thr Ala 
                 1285                1290                1295
Gln Arg Leu Ile Gln Ser His Pro Glu Ser Ala Glu Asp Leu Lys Glu 
             1300                1305                1310
Lys Cys Thr Glu Leu Asn Gln Ala Trp Thr Ser Leu Gly Lys Arg Ala 
         1315                1320                1325
Asp Gln Arg Lys Ala Lys Leu Gly Asp Ser His Asp Leu Gln Arg Phe 
     1330                1335                1340
Leu Ser Asp Phe Arg Asp Leu Met Ser Trp Ile Asn Gly Ile Arg Gly 
 1345                1350                1355                1360
Leu Val Ser Ser Asp Glu Leu Ala Lys Asp Val Thr Gly Ala Glu Ala 
                 1365                1370                1375
Leu Leu Glu Arg His Gln Glu His Arg Thr Glu Ile Asp Ala Arg Ala 
             1380                1385                1390
Gly Thr Phe Gln Ala Phe Glu Gln Phe Gly Gln Gln Leu Leu Ala His 
         1395                1400                1405
Gly His Tyr Ala Ser Pro Glu Ile Lys Glu Lys Leu Asp Ile Leu Asp 
     1410                1415                1420
Gln Glu Arg Thr Asp Leu Glu Lys Ala Trp Val Gln Arg Arg Met Met 
 1425                1430                1435                1440
Leu Asp His Cys Leu Glu Leu Gln Leu Phe His Arg Asp Cys Glu Gln 
                 1445                1450                1455
Ala Glu Asn Trp Met Ala Ala Arg Glu Ala Phe Leu Asn Thr Glu Asp 
             1460                1465                1470
Lys Gly Asp Ser Leu Asp Ser Val Glu Ala Leu Ile Lys Lys His Glu 
         1475                1480                1485
Asp Phe Asp Lys Ala Ile Asn Val Gln Glu Glu Lys Ile Ala Ala Leu 
     1490                1495                1500
Gln Ala Phe Ala Asp Gln Leu Ile Ala Val Asp His Tyr Ala Lys Gly 
 1505                1510                1515                1520
Asp Ile Ala Asn Arg Arg Asn Glu Val Leu Asp Arg Trp Arg Arg Leu 
                 1525                1530                1535
Lys Ala Gln Met Ile Glu Lys Arg Ser Lys Leu Gly Glu Ser Gln Thr 
             1540                1545                1550
Leu Gln Gln Phe Ser Arg Asp Val Asp Glu Ile Glu Ala Trp Ile Ser 
         1555                1560                1565
Glu Lys Leu Gln Thr Ala Ser Asp Glu Ser Tyr Lys Asp Pro Thr Asn 
     1570                1575                1580
Ile Gln Ser Lys His Gln Lys His Gln Ala Phe Glu Ala Glu Leu His 
 1585                1590                1595                1600
Ala Asn Ala Asp Arg Ile Arg Gly Val Ile Asp Met Gly Asn Ser Leu 
                 1605                1610                1615
Ile Glu Arg Gly Ala Cys Ala Gly Ser Glu Asp Ala Val Lys Ala Arg 
             1620                1625                1630
Leu Ala Ala Leu Ala Asp Gln Trp Gln Phe Leu Val Gln Lys Ser Ala 
         1635                1640                1645
Glu Lys Ser Gln Lys Leu Lys Glu Ala Asn Lys Gln Gln Asn Phe Asn 
     1650                1655                1660
Thr Gly Ile Lys Asp Phe Asp Phe Trp Leu Ser Glu Val Glu Ala Leu 
 1665                1670                1675                1680
Leu Ala Ser Glu Asp Tyr Gly Lys Asp Leu Ala Ser Val Asn Asn Leu 
                 1685                1690                1695
Leu Lys Lys His Gln Leu Leu Glu Ala Asp Ile Ser Ala His Glu Asp 
             1700                1705                1710
Arg Leu Lys Asp Leu Asn Ser Gln Ala Asp Ser Leu Met Thr Ser Ser 
         1715                1720                1725
Ala Phe Asp Thr Ser Gln Val Lys Glu Lys Arg Asp Thr Ile Asn Gly 
     1730                1735                1740
Arg Phe Gln Lys Ile Lys Ser Met Ala Thr Ser Arg Arg Ala Lys Leu 
 1745                1750                1755                1760
Ser Glu Ser His Arg Leu His Gln Phe Phe Arg Asp Met Asp Asp Glu 
                 1765                1770                1775
Glu Ser Trp Ile Lys Glu Lys Lys Leu Leu Val Ser Ser Glu Asp Tyr 
             1780                1785                1790
Gly Arg Asp Leu Thr Gly Val Gln Asn Leu Arg Lys Lys His Lys Arg 
         1795                1800                1805
Leu Glu Ala Glu Leu Ala Ala His Glu Pro Ala Ile Gln Gly Val Leu 
     1810                1815                1820
Asp Thr Gly Lys Lys Leu Ser Asp Asp Asn Thr Ile Gly Gln Glu Glu 
 1825                1830                1835                1840
Ile Gln Gln Arg Leu Ala Gln Phe Val Glu His Trp Lys Glu Leu Lys 
                 1845                1850                1855
Gln Leu Ala Ala Ala Arg Gly Gln Arg Leu Glu Glu Ser Leu Glu Tyr 
             1860                1865                1870
Gln Gln Phe Val Ala Asn Val Glu Glu Glu Glu Ala Trp Ile Asn Glu 
         1875                1880                1885
Lys Met Thr Leu Val Ala Ser Glu Asp Tyr Gly Asp Thr Leu Ala Ala 
     1890                1895                1900
Ile Gln Gly Leu Leu Lys Lys His Glu Ala Phe Glu Thr Asp Phe Thr 
 1905                1910                1915                1920
Val His Lys Asp Arg Val Asn Asp Val Cys Thr Asn Gly Gln Asp Leu 
                 1925                1930                1935
Ile Lys Lys Asn Asn His His Glu Glu Asn Ile Ser Ser Lys Met Lys 
             1940                1945                1950
Gly Leu Asn Gly Lys Val Ser Asp Leu Glu Lys Ala Ala Ala Gln Arg 
         1955                1960                1965
Lys Ala Lys Leu Asp Glu Asn Ser Ala Phe Leu Gln Phe Asn Trp Lys 
     1970                1975                1980
Ala Asp Val Val Glu Ser Trp Ile Gly Glu Lys Glu Asn Ser Leu Lys 
 1985                1990                1995                2000
Thr Asp Asp Tyr Gly Arg Asp Leu Ser Ser Val Gln Thr Leu Leu Thr 
                 2005                2010                2015
Lys Gln Glu Thr Phe Asp Ala Gly Leu Gln Ala Phe Gln Gln Glu Gly 
             2020                2025                2030
Ile Ala Asn Ile Thr Ala Leu Lys Asp Gln Leu Leu Ala Ala Lys His 
         2035                2040                2045
Ile Gln Ser Lys Ala Ile Glu Ala Arg His Ala Ser Leu Met Lys Arg 
     2050                2055                2060
Trp Thr Gln Leu Leu Ala Asn Ser Ala Thr Arg Lys Lys Lys Leu Leu 
 2065                2070                2075                2080
Glu Ala Gln Ser His Phe Arg Lys Val Glu Asp Leu Phe Leu Thr Phe 
                 2085                2090                2095
Ala Lys Lys Ala Ser Ala Phe Asn Ser Trp Phe Glu Asn Ala Glu Glu 
             2100                2105                2110
Asp Leu Thr Asp Pro Val Arg Cys Asn Ser Leu Glu Glu Ile Lys Ala 
         2115                2120                2125
Leu Arg Glu Ala His Asp Ala Phe Arg Ser Ser Leu Ser Ser Ala Gln 
     2130                2135                2140
Ala Asp Phe Asn Gln Leu Ala Glu Leu Asp Arg Gln Ile Lys Ser Phe 
 2145                2150                2155                2160
Arg Val Ala Ser Asn Pro Tyr Thr Trp Phe Thr Met Glu Ala Leu Glu 
                 2165                2170                2175
Glu Thr Trp Arg Asn Leu Gln Lys Ile Ile Lys Glu Arg Glu Leu Glu 
             2180                2185                2190
Leu Gln Lys Glu Gln Arg Arg Gln Glu Glu Asn Asp Lys Leu Arg Gln 
         2195                2200                2205
Glu Phe Ala Gln His Ala Asn Ala Phe His Gln Trp Ile Gln Glu Thr 
     2210                2215                2220
Arg Thr Tyr Leu Leu Asp Gly Ser Cys Met Val Glu Glu Ser Gly Thr 
 2225                2230                2235                2240
Leu Glu Ser Gln Leu Glu Ala Thr Lys Arg Lys His Gln Glu Ile Arg 
                 2245                2250                2255
Ala Met Arg Ser Gln Leu Lys Lys Ile Glu Asp Leu Gly Ala Ala Met 
             2260                2265                2270
Glu Glu Ala Leu Ile Leu Asp Asn Lys Tyr Thr Glu His Ser Thr Val 
         2275                2280                2285
Gly Leu Ala Gln Gln Trp Asp Gln Leu Asp Gln Leu Gly Met Arg Met 
     2290                2295                2300
Gln His Asn Leu Glu Gln Gln Ile Gln Ala Arg Asn Thr Thr Gly Val 
 2305                2310                2315                2320
Thr Glu Glu Ala Leu Lys Glu Phe Ser Met Met Phe Lys His Phe Asp 
                 2325                2330                2335
Lys Asp Lys Ser Gly Arg Leu Asn His Gln Glu Phe Lys Ser Cys Leu 
             2340                2345                2350
Arg Ser Leu Gly Tyr Asp Leu Pro Met Val Glu Glu Gly Glu Pro Asp 
         2355                2360                2365
Pro Glu Phe Glu Ala Ile Leu Asp Thr Val Asp Pro Asn Arg Asp Gly 
     2370                2375                2380
His Val Ser Leu Gln Glu Tyr Met Ala Phe Met Ile Ser Arg Glu Thr 
 2385                2390                2395                2400
Glu Asn Val Lys Ser Ser Glu Glu Ile Glu Ser Ala Phe Arg Ala Leu 
                 2405                2410                2415
Ser Ser Glu Gly Lys Pro Tyr Val Thr Lys Glu Glu Leu Tyr Gln Asn 
             2420                2425                2430
Leu Thr Arg Glu Gln Ala Asp Tyr Cys Val Ser His Met Lys Pro Tyr 
         2435                2440                2445
Val Asp Gly Lys Gly Arg Glu Leu Pro Thr Ala Phe Asp Tyr Val Glu 
     2450                2455                2460
Phe Thr Arg Ser Leu Phe Val Asn 
 2465                2470



<210> 1166
<211> 4734
<212> DNA
<213> Homo sapiens
<308> AL110273
<400> 1166

gagatatcc  taccttact  aacagcacc  acaaggatt  gtggaaggt  gaagtgaac  60
atcgtcagg  ttttgtgcc  gctgcgtac  tgaagaaat  ggaccccgc  cagtcagcc  120
cccgggaga  tctcctgga  gagcaaggc  gcatagcac  gcggcagga  cagattgac  180
atcaatatc  ttctctgct  gaactgggt  agaagcgta  aggcatgtt  gagaagagt  240
gcaagaagt  tatgttgtt  cgtgaagcg  atgaactac  gcaatggat  aatgagaag  300
aagccgctc  gacaagtga  gaggtggga  cagacttgg  gcaggttga  gtgctccag  360
agaagtttg  tgacttcca  aaggacctg  aggccaatg  gtcacggtt  aaggacatt  420
acaaggtag  tgaagacct  gagtctgaa  gtcttatgg  agaggaggt  caggctgtg  480
aacaacagg  agtgtatgg  atgatgccc  gggatgaaa  tgattccaa  acagcctcc  540
cgtggaagt  tgctcgtct  atggttcac  ccgtggcca  ctttaattc  atcaaggag  600
tgaatgagc  ctggcggtc  ctacagcag  tggccgagg  acggagcca  ctcttgggc  660
gcgcccatg  agtacagag  ttccacaga  atgctgatg  aaccaaaga  tggattgaa  720
agaagaatc  agctctaaa  acagacaat  atggacatg  tctcgccag  gtccaggcc  780
tgcaacgca  gcatgaggg  ttcgagagg  accttgcgg  tctcggtga  aaggtaaac  840
cccttggtg  aacagcaga  cgcctgatc  agtcccatc  cgagtcagc  gaagacctg  900
aggaaaagt  cacagagtt  aaccaggcc  ggagcagcc  ggggaaacg  gcagatcag  960
gcaaggcaa  gttgggtga  tcccacgac  tgcagcgct  ccttagcga  ttccgggac  1020
tcatgtctt  gatcaatgg  atacggggg  tggtgtcct  agatgagct  gccaaggat  1080
tcaccggag  tgaggcatt  ctggagcga  accagggac  ccggacaga  atcgatgcc  1140
gggctggca  tttccaggc  tttgagcag  ttggacagc  gctgttggc  cacggacac  1200
atgccagcc  tgagatcaa  cagaaactt  atattcttg  ccaggagcg  gcagacctg  1260
agaaggcct  ggttcagcg  aggatgatg  tggatcagt  ccttgaact  cagctgttc  1320
atcgggact  tgagcaagc  gagaactgg  tggctgccc  ggaggcctt  ttgaatacc  1380
aagacaaag  agactcact  gacagcgta  aggctctga  caaaaaaca  gaagacttt  1440
acaaagcga  taacgtcca  gaagagaag  ttgctgctc  gcaggcctt  gccgaccag  1500
tcatcgctg  cggccatta  gccaaggga  acatttcta  ccggcgcaa  gaggtcttg  1560
acaggtggc  acgtctgaa  gcccagatg  ttgagaaaa  gtcaaagct  ggagaatct  1620
aaaccctcc  acagttcag  cgggatgtg  atgagattg  ggcttggat  agtgaaaaa  1680
tgcaaacag  gagtgatga  tcgtacaag  atcccacca  catccagag  aagcaccag  1740
agcaccagg  ttttgaagc  gagctgcat  ccaacgctg  ccggatccg  ggggttatc  1800
acatgggca  ctccctcat  gaacgtgga  cctgtgccg  cagtgagga  gctgtcaag  1860
cccgcctgg  tgccttagc  gaccagtgg  agttcttgg  gcaaaagtc  gcggaaaag  1920
gccagaaac  gaaagaagc  aacaagcag  agaacttca  cacagggat  aaggacttt  1980
acttctggc  gtctgaggt  gaggccctg  tggcatccg  agattatgg  aaagacctg  2040
cttctgtga  caacctgct  aaaaagcat  aactgctgg  agcagatat  tctgcccat  2100
aggatcgcc  gaaggacct  aacagccag  cagacagcc  gatgaccag  agtgccttc  2160
acacctccc  agtaaagga  aagagggac  ccatcaacg  gcgcttcca  aagatcaag  2220
gcatggcgg  ctcccggcg  gccaagctg  atgaatccc  tcgcctgca  cagttcttc  2280
gggacatgg  tgacgagga  tcctggatc  aggagaaga  gctgctggt  ggctcagag  2340
actacggcc  ggacctaac  ggcgtgcag  acctgagga  gaagcacaa  cggctggaa  2400
cagaactgg  tgcgcatga  ccggctatt  agggtgtcc  ggacactgg  aagaagctg  2460
ccgatgaca  caccatcgg  aaagaggag  tccagcagc  gctggcgca  tttgtggag  2520
actggaaag  gctgaagca  ctggcagct  cccggggtc  gcggctgga  gagtccttg  2580
aatatcagc  gtttgtagc  aatgtggaa  aggaagaag  ctggatcaa  gagaaaatg  2640
ccctggtgg  cagcgaaga  tatggcgac  ctcttgccg  catccaggg  ttactgaag  2700
aacatgaag  ttttgagac  gacttcacc  tccacaagg  tcgcgtgaa  gatgtctgc  2760
ccaatggac  agacctcat  aagaagaac  atcaccatg  ggagaacat  tcttcaaag  2820
tgaagggcc  gaacgggaa  gtgtcagac  tggagaaag  tgcagccca  agaaaggcg  2880
agctggatg  gaactcggc  ttccttcag  tcaactgga  ggcggacgt  gtggagtcc  2940
ggatcggtg  aaaggagaa  agcttgaag  cagatgatt  tggccgaga  ctgtcttct  3000
tgcagacgc  cctcaccaa  caggaaact  ttgacgctg  gctgcaggc  ttccagcag  3060
aaggcattg  caacatcac  gccctcaaa  atcagcttc  cgccgccaa  cacgttcag  3120
ccaaggcca  cgaggcccg  cacgcctcc  tcatgaaga  gtggagcca  cttctggcc  3180
actcagccg  ccgcaagaa  aagcttctg  aggctcaga  tcacttccg  aaggtggag  3240
acctcttcc  gaccttcgc  aaaaaggct  ctgccttca  cagctggtt  gaaaatgca  3300
aggaggact  aacagaccc  gtgcgctgc  actccttgg  agaaatcaa  gctttgcgc  3360
aggcccacg  cgccttccg  tcctccctc  gctctgccc  ggctgactt  aaccagctg  3420
ccgagctgg  ccgccagat  aagagcttc  gcgtagcct  caaccccta  acctggttt  3480
ccatggagg  cctggagga  acctggagg  acctacaga  aatcatcaa  gagagggag  3540
tggagctgc  gaaggagca  cggcggcag  aggagaacg  caagctgcg  caggagttt  3600
cccagcacg  caacgcctt  caccagtgg  tccaagaga  caggacata  ctcctcgat  3660
ggtcctgta  ggtggaaga  tcggggacc  tcgaatccc  gcttgaagc  accaaacgc  3720
agcaccagg  aatccgagc  atgagaagt  agctcaaaa  gatcgagga  ctgggggcc  3780
ccatggagg  ggccctcat  ctggacaac  agtacacgg  gcacagcac  gtgggcctc  3840
cccagcagt  ggaccagct  gaccagctg  gcatgcgca  gcagcacaa  ctggagcag  3900
agatccagg  caggaacac  acaggtgtg  ctgaggagg  cctcaaaga  ttcagcatg  3960
tgtttaaac  ctttgacta  gacaagtct  gcaggctga  ccatcagga  ttcaaatct  4020
gcctgcgct  cctgggcta  gacctgccc  tggtggagg  aggggaacc  gaccctgag  4080
tcgaggcaa  cctggacac  gtggatccg  acagagatg  ccatgtctc  ttgcaagaa  4140
acatggctt  catgatcag  cgcgaaact  agaacgtca  gtccagcga  gagattgag  4200
gcgccttcc  ggccctctg  tcagaggga  agccttacg  gaccaagga  gagctctac  4260
agaacctga  ccgggaaca  gccgactac  gcgtctccc  catgaagcc  tacgtggac  4320
gcaagggcc  cgagctccc  accgcgttc  actacgtgg  gttcacccg  tcgcttttc  4380
tgaactgag  cactccctg  gtcacccac  cctcgctgc  tgccctgcg  cgccttgct  4440
catgtccgc  cctctgtgt  ctctcactt  ccactgtaa  cttaagcct  cttagcttg  4500
aataagact  aggagaata  ggtgcttca  taacccgct  ccggtccag  cacaatcat  4560
atgtcactg  ggggaccca  atctgtgtc  tgaagcagc  gccctcatt  cgacttcag  4620
aaatcgaag  agctggctc  tccccttgt  ctctctccc  ccctccccc  aatctgttt  4680
catgtaaaa  acaaataaa  gatgacttc  cccaaaaaa  aaaaaaaaa  aaac  4734



<210> 1167
<211> 2472
<212> PRT
<213> Homo sapiens
<308> Q13813
<400> 1167

Met Asp Pro Ser Gly Val Lys Val Leu Glu Thr Ala Glu Asp Ile Gln 
  1               5                  10                  15
Glu Arg Arg Gln Gln Val Leu Asp Arg Tyr His Arg Phe Lys Glu Leu 
             20                  25                  30
Ser Thr Leu Arg Arg Gln Lys Leu Glu Asp Ser Tyr Arg Phe Gln Phe 
         35                  40                  45
Phe Gln Arg Asp Ala Glu Glu Leu Glu Lys Trp Ile Gln Glu Lys Leu 
     50                  55                  60
Gln Ile Ala Ser Asp Glu Asn Tyr Lys Asp Pro Thr Asn Leu Gln Gly 
 65                  70                  75                  80
Lys Leu Gln Lys His Gln Ala Phe Glu Ala Glu Val Gln Ala Asn Ser 
                 85                  90                  95
Gly Ala Ile Val Lys Leu Asp Glu Thr Gly Asn Leu Met Ile Ser Glu 
             100                105                110
Gly His Phe Ala Ser Glu Thr Ile Arg Thr Arg Leu Met Glu Leu His 
         115                120                125
Arg Gln Trp Glu Leu Leu Leu Glu Lys Met Arg Glu Lys Gly Ile Lys 
     130                135                140
Leu Leu Gln Ala Gln Asn Leu Val Gln Tyr Leu Arg Glu Cys Glu Asp 
 145                150                155                160
Val Met Asp Trp Ile Asn Asp Lys Glu Ala Ile Val Thr Ser Glu Glu 
                 165                170                175
Leu Gly Gln Asp Leu Glu His Val Glu Val Leu Gln Lys Lys Phe Glu 
             180                185                190
Glu Phe Gln Thr Asp Met Ala Ala His Glu Glu Arg Val Asn Glu Val 
         195                200                205
Asn Gln Phe Ala Ala Lys Leu Ile Gln Glu Gln His Pro Glu Glu Glu 
     210                215                220
Leu Ile Lys Thr Lys Gln Asp Glu Val Asn Ala Ala Trp Gln Arg Leu 
 225                230                235                240
Lys Gly Leu Ala Leu Gln Arg Gln Gly Lys Leu Phe Gly Ala Ala Glu 
                 245                250                255
Val Gln Arg Phe Asn Arg Asp Val Asp Glu Thr Ile Ser Trp Ile Lys 
             260                265                270
Glu Lys Glu Gln Leu Met Ala Ser Asp Asp Phe Gly Arg Asp Leu Ala 
         275                280                285
Ser Val Gln Ala Leu Leu Arg Lys His Glu Gly Leu Glu Arg Asp Leu 
     290                295                300
Ala Ala Leu Glu Asp Lys Val Lys Ala Leu Cys Ala Glu Ala Asp Arg 
 305                310                315                320
Leu Gln Gln Ser His Pro Leu Ser Ala Thr Gln Ile Gln Val Lys Arg 
                 325                330                335
Glu Glu Leu Ile Thr Asn Trp Glu Gln Ile Arg Thr Leu Ala Ala Glu 
             340                345                350
Arg His Ala Arg Leu Asn Asp Ser Tyr Arg Leu Gln Arg Phe Leu Ala 
         355                360                365
Asp Phe Arg Asp Leu Thr Ser Trp Val Thr Glu Met Lys Ala Leu Ile 
     370                375                380
Asn Ala Asp Glu Leu Ala Ser Asp Val Ala Gly Ala Glu Ala Leu Leu 
 385                390                395                400
Asp Arg His Gln Glu His Lys Gly Glu Ile Asp Ala His Glu Asp Ser 
                 405                410                415
Phe Lys Ser Ala Asp Glu Ser Gly Gln Ala Leu Leu Ala Ala Gly His 
             420                425                430
Tyr Ala Ser Asp Glu Val Arg Glu Lys Leu Thr Val Leu Ser Glu Glu 
         435                440                445
Arg Ala Ala Leu Leu Glu Leu Trp Glu Leu Arg Arg Gln Gln Tyr Glu 
     450                455                460
Gln Cys Met Asp Leu Gln Leu Phe Tyr Arg Asp Thr Glu Gln Val Asp 
 465                470                475                480
Asn Trp Met Ser Lys Gln Glu Ala Phe Leu Leu Asn Glu Asp Leu Gly 
                 485                490                495
Asp Phe Leu Asp Ser Val Glu Ala Leu Leu Lys Lys His Glu Asp Phe 
             500                505                510
Glu Lys Ser Leu Ser Ala Gln Glu Glu Lys Ile Thr Ala Leu Asp Glu 
         515                520                525
Phe Ala Thr Lys Leu Ile Gln Asn Asn His Tyr Ala Met Glu Asp Val 
     530                535                540
Ala Thr Arg Arg Asp Ala Leu Leu Ser Arg Arg Asn Ala Leu His Glu 
 545                550                555                560
Arg Ala Met Arg Arg Arg Ala Gln Leu Ala Asp Ser Phe His Leu Gln 
                 565                570                575
Gln Phe Phe Arg Asp Ser Asp Glu Leu Lys Ser Trp Val Asn Glu Lys 
             580                585                590
Met Lys Thr Ala Thr Asp Glu Ala Tyr Lys Asp Pro Ser Asn Leu Gln 
         595                600                605
Gly Lys Val Gln Lys His Gln Ala Phe Glu Ala Glu Leu Ser Ala Asn 
     610                615                620
Gln Ser Arg Ile Asp Ala Leu Glu Lys Ala Gly Gln Lys Leu Ile Asp 
 625                630                635                640
Val Asn His Tyr Ala Lys Asp Glu Val Ala Ala Arg Met Asn Glu Val 
                 645                650                655
Ile Ser Leu Trp Lys Lys Leu Leu Glu Ala Thr Glu Leu Lys Gly Ile 
             660                665                670
Lys Leu Arg Glu Ala Asn Gln Gln Gln Gln Phe Asn Arg Asn Val Glu 
         675                680                685
Asp Ile Glu Leu Trp Leu Tyr Glu Val Glu Gly His Leu Ala Ser Asp 
     690                695                700
Asp Tyr Gly Lys Asp Leu Thr Asn Val Gln Asn Leu Gln Lys Lys His 
 705                710                715                720
Ala Leu Leu Glu Ala Asp Val Ala Ala His Gln Asp Arg Ile Asp Gly 
                 725                730                735
Val Thr Ile Gln Ala Arg Gln Phe Gln Asp Ala Gly His Phe Asp Ala 
             740                745                750
Glu Asn Ile Lys Lys Lys Gln Glu Ala Leu Val Ala Arg Tyr Glu Ala 
         755                760                765
Leu Lys Glu Pro Met Val Ala Arg Lys Gln Lys Leu Ala Asp Ser Leu 
     770                775                780
Arg Leu Gln Gln Leu Phe Arg Asp Val Glu Asp Glu Glu Thr Trp Ile 
 785                790                795                800
Arg Glu Lys Glu Pro Ile Ala Ala Ser Thr Asn Arg Gly Lys Asp Leu 
                 805                810                815
Ile Gly Val Gln Asn Leu Leu Lys Lys His Gln Ala Leu Gln Ala Glu 
             820                825                830
Ile Ala Gly His Glu Pro Arg Ile Lys Ala Val Thr Gln Lys Gly Asn 
         835                840                845
Ala Met Val Glu Glu Gly His Phe Ala Ala Glu Asp Val Lys Ala Lys 
     850                855                860
Leu His Glu Leu Asn Gln Lys Trp Glu Ala Leu Lys Ala Lys Ala Ser 
 865                870                875                880
Gln Arg Arg Gln Asp Leu Glu Asp Ser Leu Gln Ala Gln Gln Tyr Phe 
                 885                890                895
Ala Asp Ala Asn Glu Ala Glu Ser Trp Met Arg Glu Lys Glu Pro Ile 
             900                905                910
Val Gly Ser Thr Asp Tyr Gly Lys Asp Glu Asp Ser Ala Glu Ala Leu 
         915                920                925
Leu Lys Lys His Glu Ala Leu Met Ser Asp Leu Ser Ala Tyr Gly Ser 
     930                935                940
Ser Ile Gln Ala Leu Arg Glu Gln Ala Gln Ser Cys Arg Gln Gln Val 
 945                950                955                960
Ala Pro Thr Asp Asp Glu Thr Gly Lys Glu Leu Val Leu Ala Leu Tyr 
                 965                970                975
Asp Tyr Gln Glu Lys Ser Pro Arg Glu Val Thr Met Lys Lys Gly Asp 
             980                985                990
Ile Leu Thr Leu Leu Asn Ser Thr Asn Lys Asp Trp Trp Lys Val Glu 
         995                1000                1005
Val Asn Asp Arg Gln Gly Phe Val Pro Ala Ala Tyr Val Lys Lys Leu 
     1010                1015                1020
Asp Pro Ala Gln Ser Ala Ser Arg Glu Asn Leu Leu Glu Glu Gln Gly 
 1025                1030                1035                1040
Ser Ile Ala Leu Arg Gln Glu Gln Ile Asp Asn Gln Thr Arg Ile Thr 
                 1045                1050                1055
Lys Glu Ala Gly Ser Val Ser Leu Arg Met Lys Gln Val Glu Glu Leu 
             1060                1065                1070
Tyr His Ser Leu Leu Glu Leu Gly Glu Lys Arg Lys Gly Met Leu Glu 
         1075                1080                1085
Lys Ser Cys Lys Lys Phe Met Leu Phe Arg Glu Ala Asn Glu Leu Gln 
     1090                1095                1100
Gln Trp Ile Asn Glu Lys Glu Ala Ala Leu Thr Ser Glu Glu Val Gly 
 1105                1110                1115                1120
Ala Asp Leu Glu Gln Val Glu Val Leu Gln Lys Lys Phe Asp Asp Phe 
                 1125                1130                1135
Gln Lys Asp Leu Lys Ala Asn Glu Ser Arg Leu Lys Asp Ile Asn Lys 
             1140                1145                1150
Val Ala Glu Asp Leu Glu Ser Glu Gly Leu Met Ala Glu Glu Val Gln 
         1155                1160                1165
Ala Val Gln Gln Gln Glu Val Tyr Gly Met Met Pro Arg Asp Glu Thr 
     1170                1175                1180
Asp Ser Lys Thr Ala Ser Pro Trp Lys Ser Ala Arg Leu Met Val His 
 1185                1190                1195                1200
Thr Val Ala Thr Phe Asn Ser Ile Lys Glu Leu Asn Glu Arg Trp Arg 
                 1205                1210                1215
Ser Leu Gln Gln Leu Ala Glu Glu Arg Ser Gln Leu Leu Gly Ser Ala 
             1220                1225                1230
His Glu Val Gln Arg Phe His Arg Asp Ala Asp Glu Thr Lys Glu Trp 
         1235                1240                1245
Ile Glu Glu Lys Asn Gln Ala Leu Asn Thr Asp Asn Tyr Gly His Asp 
     1250                1255                1260
Leu Ala Ser Val Gln Ala Leu Gln Arg Lys His Glu Gly Phe Glu Arg 
 1265                1270                1275                1280
Asp Leu Ala Ala Leu Gly Asp Lys Val Asn Ser Leu Gly Glu Thr Ala 
                 1285                1290                1295
Glu Arg Leu Thr Gln Ser His Pro Glu Ser Ala Glu Asp Leu Gln Glu 
             1300                1305                1310
Lys Cys Thr Glu Leu Asn Gln Ala Trp Ser Ser Leu Gly Lys Arg Ala 
         1315                1320                1325
Asp Gln Arg Lys Ala Lys Leu Gly Asp Ser His Asp Leu Gln Arg Phe 
     1330                1335                1340
Leu Ser Asp Phe Arg Asp Leu Met Ser Trp Ile Asn Gly Ile Arg Gly 
 1345                1350                1355                1360
Leu Val Ser Ser Asp Glu Leu Ala Lys Asp Val Thr Gly Ala Glu Ala 
                 1365                1370                1375
Leu Leu Glu Arg His Gln Glu His Arg Thr Glu Ile Asp Ala Arg Ala 
             1380                1385                1390
Gly Thr Phe Gln Ala Phe Glu Gln Phe Gly Gln Gln Leu Leu Ala His 
         1395                1400                1405
Gly His Tyr Ala Ser Pro Glu Ile Lys Gln Lys Leu Asp Ile Leu Asp 
     1410                1415                1420
Gln Glu Arg Ala Asp Leu Glu Lys Ala Trp Val Gln Arg Arg Met Met 
 1425                1430                1435                1440
Leu Asp Gln Cys Leu Glu Leu Gln Leu Phe His Arg Asp Cys Glu Gln 
                 1445                1450                1455
Ala Glu Asn Trp Met Ala Ala Arg Glu Ala Phe Leu Asn Thr Glu Asp 
             1460                1465                1470
Lys Gly Asp Ser Leu Asp Ser Val Glu Ala Leu Ile Lys Lys His Glu 
         1475                1480                1485
Asp Phe Asp Lys Ala Ile Asn Val Gln Glu Glu Lys Ile Ala Ala Leu 
     1490                1495                1500
Gln Ala Phe Ala Asp Gln Leu Ile Ala Ala Gly His Tyr Ala Lys Gly 
 1505                1510                1515                1520
Asp Ile Ser Ser Arg Arg Asn Glu Val Leu Asp Arg Trp Arg Arg Leu 
                 1525                1530                1535
Lys Ala Gln Met Ile Glu Lys Arg Ser Lys Leu Gly Glu Ser Gln Thr 
             1540                1545                1550
Leu Gln Gln Phe Ser Arg Asp Val Asp Glu Ile Glu Ala Trp Ile Ser 
         1555                1560                1565
Glu Lys Leu Gln Thr Ala Ser Asp Glu Ser Tyr Lys Asp Pro Thr Asn 
     1570                1575                1580
Ile Gln Ser Lys His Gln Lys His Gln Ala Phe Glu Ala Glu Leu His 
 1585                1590                1595                1600
Ala Asn Ala Asp Arg Ile Arg Gly Val Ile Asp Met Gly Asn Ser Leu 
                 1605                1610                1615
Ile Glu Arg Gly Ala Cys Ala Gly Asn Glu Asp Ala Val Lys Ala Arg 
             1620                1625                1630
Leu Ala Ala Leu Ala Asp Gln Trp Gln Phe Leu Val Gln Lys Ser Ala 
         1635                1640                1645
Glu Lys Ser Gln Lys Leu Lys Glu Ala Asn Lys Gln Gln Asn Phe Asn 
     1650                1655                1660
Thr Gly Ile Lys Asp Ile Ala Phe Trp Leu Ser Glu Val Glu Ala Leu 
 1665                1670                1675                1680
Leu Ala Ser Glu Asp Tyr Gly Lys Asp Leu Ala Ser Val Asn Asn Leu 
                 1685                1690                1695
Leu Lys Lys His Gln Leu Leu Glu Ala Asp Ile Ser Ala His Glu Asp 
             1700                1705                1710
Arg Leu Lys Asp Leu Asn Ser Gln Ala Asp Ser Leu Met Thr Ser Ser 
         1715                1720                1725
Ala Phe Asp Thr Ser Gln Val Lys Asp Lys Arg Asp Thr Ile Asn Gly 
     1730                1735                1740
Arg Phe Gln Lys Ile Lys Ser Met Ala Ala Ser Arg Arg Ala Lys Leu 
 1745                1750                1755                1760
Asn Glu Ser His Arg Leu His Gln Phe Phe Arg Asp Met Asp Asp Glu 
                 1765                1770                1775
Glu Ser Trp Ile Lys Glu Lys Lys Leu Leu Val Gly Ser Glu Asp Tyr 
             1780                1785                1790
Gly Arg Asp Leu Thr Gly Val Gln Asn Leu Arg Lys Lys His Lys Arg 
         1795                1800                1805
Leu Glu Ala Glu Leu Ala Ala His Glu Pro Ala Ile Gln Gly Val Leu 
     1810                1815                1820
Asp Thr Gly Lys Lys Leu Ser Asp Asp Asn Thr Ile Gly Lys Glu Glu 
 1825                1830                1835                1840
Ile Gln Gln Arg Leu Ala Gln Phe Val Glu His Trp Lys Glu Leu Lys 
                 1845                1850                1855
Gln Leu Ala Ala Ala Arg Gly Gln Arg Leu Glu Glu Ser Leu Glu Tyr 
             1860                1865                1870
Gln Gln Phe Val Ala Asn Val Glu Glu Glu Glu Ala Trp Ile Asn Glu 
         1875                1880                1885
Lys Met Thr Leu Val Ala Ser Glu Asp Tyr Gly Asp Thr Leu Ala Ala 
     1890                1895                1900
Ile Gln Gly Leu Leu Lys Lys His Glu Ala Phe Glu Thr Ala Phe Thr 
 1905                1910                1915                1920
Val His Lys Asp Arg Val Asn Asp Val Cys Thr Asn Gly Gln Asp Leu 
                 1925                1930                1935
Ile Lys Lys Asn Asn His His Glu Glu Asn Ile Ser Ser Lys Met Lys 
             1940                1945                1950
Gly Leu Asn Gly Lys Val Ser Asp Leu Glu Lys Ala Ala Ala Gln Arg 
         1955                1960                1965
Lys Ala Asn Val Asp Glu Asn Ser Ala Phe Leu Gln Phe Asn Trp Lys 
     1970                1975                1980
Ala Asp Val Val Glu Ser Trp Ile Gly Glu Lys Glu Asn Ser Leu Lys 
 1985                1990                1995                2000
Thr Asp Asp Tyr Gly Arg Asp Leu Ser Ser Val Gln Thr Leu Leu Thr 
                 2005                2010                2015
Lys Gln Glu Thr Phe Asp Ala Gly Leu Gln Ala Phe Gln Gln Glu Gly 
             2020                2025                2030
Ile Ala Asn Ile Thr Ala Leu Lys Asp Gln Leu Leu Ala Ala Lys His 
         2035                2040                2045
Val Gln Ser Lys Ala Ile Glu Ala Arg His Ala Ser Leu Met Lys Arg 
     2050                2055                2060
Trp Ser Gln Leu Leu Ala Asn Ser Ala Ala Arg Lys Lys Lys Leu Leu 
 2065                2070                2075                2080
Glu Ala Gln Ser His Phe Arg Lys Val Glu Asp Leu Phe Leu Thr Phe 
                 2085                2090                2095
Ala Lys Lys Ala Ser Ala Phe Asn Ser Trp Phe Glu Asn Ala Glu Glu 
             2100                2105                2110
Asp Leu Thr Asp Pro Val Arg Cys Asn Ser Leu Glu Glu Ile Lys Ala 
         2115                2120                2125
Leu Arg Glu Ala His Asp Ala Phe Arg Ser Ser Leu Ser Ser Ala Gln 
     2130                2135                2140
Ala Asp Phe Asn Gln Leu Ala Glu Leu Asp Arg Gln Ile Lys Ser Phe 
 2145                2150                2155                2160
Arg Val Ala Ser Asn Pro Tyr Thr Trp Phe Thr Met Glu Ala Leu Glu 
                 2165                2170                2175
Glu Thr Trp Arg Asn Leu Gln Lys Ile Ile Lys Glu Arg Glu Leu Glu 
             2180                2185                2190
Leu Gln Lys Glu Gln Arg Arg Gln Glu Glu Asn Asp Lys Leu Arg Gln 
         2195                2200                2205
Glu Phe Ala Gln His Ala Asn Ala Phe His Gln Trp Ile Gln Glu Thr 
     2210                2215                2220
Arg Thr Tyr Leu Leu Asp Gly Ser Cys Met Val Glu Glu Ser Gly Thr 
 2225                2230                2235                2240
Leu Glu Ser Gln Leu Glu Ala Thr Lys Arg Lys His Gln Glu Ile Arg 
                 2245                2250                2255
Ala Met Arg Ser Gln Leu Lys Lys Ile Glu Asp Leu Gly Ala Ala Met 
             2260                2265                2270
Glu Glu Ala Leu Ile Leu Asp Asn Lys Tyr Thr Glu His Ser Thr Val 
         2275                2280                2285
Gly Leu Ala Gln Gln Trp Asp Gln Leu Asp Gln Leu Gly Met Arg Met 
     2290                2295                2300
Gln His Asn Leu Glu Gln Gln Ile Gln Ala Arg Asn Thr Thr Gly Val 
 2305                2310                2315                2320
Thr Glu Glu Ala Leu Lys Glu Phe Ser Met Met Phe Lys His Phe Asp 
                 2325                2330                2335
Lys Asp Lys Ser Gly Arg Leu Asn His Gln Asp Gly Lys Ser Cys Leu 
             2340                2345                2350
Arg Ser Leu Gly Tyr Asp Leu Pro Met Val Glu Glu Gly Glu Pro Asp 
         2355                2360                2365
Pro Glu Phe Glu Ala Ile Leu Asp Thr Val Asp Pro Asn Arg Asp Gly 
     2370                2375                2380
His Val Ser Leu Gln Glu Tyr Met Ala Phe Met Ile Ser Arg Glu Thr 
 2385                2390                2395                2400
Glu Asn Val Lys Ser Ser Glu Glu Ile Glu Ser Ala Phe Arg Ala Leu 
                 2405                2410                2415
Ser Ser Glu Gly Lys Pro Tyr Val Thr Lys Glu Glu Leu Tyr Gln Asn 
             2420                2425                2430
Leu Thr Arg Glu Gln Ala Asp Tyr Cys Val Ser His Met Lys Pro Ile 
         2435                2440                2445
Val Asp Gly Lys Gly Arg Glu Leu Pro Thr Ala Phe Asp Tyr Val Glu 
     2450                2455                2460
Phe Thr Arg Ser Leu Phe Val Asn 
 2465                2470



<210> 1168
<211> 3312
<212> DNA
<213> Rattus norvegicus
<308> AF084205
<400> 1168

tctgcagta  ggtagatta  tatttatgc  tttatgcca  tgtggcttc  ttcatacag  60
tgaaccaag  tttgggata  cagtataaa  ttagaatca  acagctgac  gctcagcag  120
atgccatca  ctaacagag  aggcagtct  aaggaccct  aaatcgcag  gctcttctt  180
aaagaagat  cggaaaaac  cttcacaga  ctcagagaa  tcggccatg  gagctttgg  240
gcagtttat  ttgcacgag  tgtgcgtac  aatgaagtg  tggccatca  gaaaatgtc  300
tatagtgga  agcagtcta  tgagaaatg  caggatatt  ttaaggaag  caagtttct  360
caaagaata  aacatccca  cagtataga  tacaaaggc  gctatttac  tgaacacac  420
gcatggctt  taatggaat  ttgtttagg  tctgcttcg  atttactag  agttcataa  480
aagccatta  aagaagtgg  aatagcagc  attacacat  gtgctctcc  gggattagc  540
tatttacat  ctcatacca  gatccatag  gatatcaaa  caggaaata  ccttctgac  600
gaaccaggc  aagtgaaac  tgctgactt  ggatctgct  ccatggcct  ccctgccaa  660
tcttttgtg  gaacaccat  ttggatggc  ccagaagta  ttttagcca  ggatgaagg  720
caatatgat  gcaaagttg  tgtatggtc  cttggaata  catgtattg  attagccga  780
aggaagcct  ctttattta  tatgaatgc  atgagtgcc  tatatcaca  agcccaaaa  840
gaatcccct  cactacagt  taatgaatg  tctgattat  ttcgaaact  tgtagattc  900
tgcctccag  aaatccctc  agatcgccc  acatcagag  aacttttaa  gcacatgtt  960
gttcttcga  agcgccctg  aacagtgtt  atagatctt  ttcaaagga  aaaggatgc  1020
gtaagagag  tggacaatc  acaatatcg  aagatgaag  aactccttt  ccaggaggc  1080
cataatgga  cagcagtag  agcacagga  gaagaggag  agcaagatc  tggtggtgg  1140
cggacagga  cagtaaata  tgttggaag  aatcagtct  tccccagta  gtctatcag  1200
gccagtagc  aaagcagca  tgttaatag  cttccagat  catcggatg  caagagtga  1260
ctagacatg  tggagggag  ccatacagt  atgtctaac  gttctgtca  ccacttaaa  1320
cctgaggag  aaaattacc  agaagaagg  gatcctaga  caagagcat  agctccaca  1380
tctccacct  aagtgtctc  tcacaaatc  cattatcgt  atagagaac  ctttgcaac  1440
atacgaaca  catcactgg  tacaagaca  atgcaagaa  atgagcagg  ctctgaact  1500
agagaacag  tgtctggtt  taagcggat  aggcgacag  atcagaagc  gctgatgac  1560
ctggaaaat  aactgaagg  agaaatgga  gaacatcgg  tcagattag  caaagatct  1620
gaaactcag  gcaacaatt  cgctgcaga  atggagaaa  ttattaaga  acaccaagc  1680
tctatggaa  aagaggcta  agtgatggc  aacgaggag  aaaaattcc  acaacacat  1740
caggctcaa  agaagaaag  actgaatag  tttttggag  ctcaaaaaa  agaatataa  1800
cttcgaaaa  agcagctta  ggaggagct  aatgaaaac  agagcacac  taaaaaaga  1860
aagcaggaa  ggctttcaa  gcagaagga  aatattcaa  attttcagg  agaagaaga  1920
gctaatctt  ttcgacgtc  aaggcagta  ctagagcta  aatgtcgtc  cttcaaaag  1980
agaatgtta  ttggtcggc  taacttgga  caggacctt  tcagggagg  gttaaacaa  2040
aggcagact  agaaggact  agaacatgc  atgttactg  gacagcatg  atccatgca  2100
gaactggag  ttcgccacc  caacactat  cagaagatg  gctgtgagt  gatcagact  2160
caacatcaa  ctgagctta  taaccagct  gaatacaat  agagaaggg  acgggaact  2220
agacggaaa  atgtcatgg  agttcgaca  cagcctaag  gtttgaagt  taaagaact  2280
caaataaaa  agcagtttc  ggatacctg  aaaattcaa  ccagacagt  caaagcatt  2340
aggaatcac  tactggaga  tacaccaaa  agtgagcac  aagctgttc  gaaaagact  2400
aaggaggaa  agactcgga  gttagccat  ttggctgag  agtatgatc  tagcattaa  2460
gaaatgctc  ccacacaag  tctgcgttt  gatgaagca  aggaagcag  atgccaggt  2520
ttgaagatg  agctacagc  ggaactgga  ctgttgaat  catatcaga  caaaatcaa  2580
atgcaggct  aggcccaac  tgatcgaga  cttcgagag  tggaacaaa  ggtctccct  2640
cggagagca  tcttagaac  gaagattga  gaagagatg  tggctttgc  gaatgaacg  2700
acagaacga  tacgtagcc  gctcgagcg  caggccaga  aaattgaag  ttttgactc  2760
gaaagcatg  gattaggtt  tagtaacat  gtcctttct  atctctccc  tgaggcatt  2820
agccacagc  acccaggag  ttctagctg  tctcacaat  ctactgggg  ttcaggacc  2880
cactggggt  atcccatgg  tggcacacc  caagcttgg  gtcatccga  gcaaggcgg  2940
ccccaacca  ggggtcacc  ctcagggcc  atgcaaggg  tacctcgag  tagcagtat  3000
ggagtccgc  atagccccc  ggctctgag  cggacagct  ctgggggac  gacggaaca  3060
ggcatgagc  gaagcacga  tgtcacttc  caaatatcc  atgggtcac  catgtctta  3120
acataataa  tgaaagtgg  aattccgct  gagctgtct  ccaaaagaa  ctgcctaca  3180
acatcagca  agcagcctc  tcacttggg  actaccggg  ggaagctgt  catatggta  3240
attttattc  tctttgtaa  gcgttatgt  ttgtgttta  taattggga  gtcatagta  3300
ttggctgcc  gg  3312



<210> 1169
<211> 1001
<212> PRT
<213> Rattus norvegicus
<308> AAC71014
<400> 1169

Met Pro Ser Thr Asn Arg Ala Gly Ser Leu Lys Asp Pro Glu Ile Ala 
  1               5                  10                  15
Glu Leu Phe Phe Lys Glu Asp Pro Glu Lys Leu Phe Thr Asp Leu Arg 
             20                  25                  30
Glu Ile Gly His Gly Ser Phe Gly Ala Val Tyr Phe Ala Arg Asp Val 
         35                  40                  45
Arg Thr Asn Glu Val Val Ala Ile Lys Lys Met Ser Tyr Ser Gly Lys 
     50                  55                  60
Gln Ser Thr Glu Lys Trp Gln Asp Ile Ile Lys Glu Val Lys Phe Leu 
 65                  70                  75                  80
Gln Arg Ile Lys His Pro Asn Ser Ile Glu Tyr Lys Gly Cys Tyr Leu 
                 85                  90                  95
Arg Glu His Thr Ala Trp Leu Val Met Glu Tyr Cys Leu Gly Ser Ala 
             100                105                110
Ser Asp Leu Leu Glu Val His Lys Lys Pro Leu Gln Glu Val Glu Ile 
         115                120                125
Ala Ala Ile Thr His Gly Ala Leu Gln Gly Leu Ala Tyr Leu His Ser 
     130                135                140
His Thr Met Ile His Arg Asp Ile Lys Ala Gly Asn Ile Leu Leu Thr 
 145                150                155                160
Glu Pro Gly Gln Val Lys Leu Ala Asp Phe Gly Ser Ala Ser Met Ala 
                 165                170                175
Ser Pro Ala Asn Ser Phe Val Gly Thr Pro Tyr Trp Met Ala Pro Glu 
             180                185                190
Val Ile Leu Ala Met Asp Glu Gly Gln Tyr Asp Gly Lys Val Asp Val 
         195                200                205
Trp Ser Leu Gly Ile Thr Cys Ile Glu Leu Ala Glu Arg Lys Pro Pro 
     210                215                220
Leu Phe Asn Met Asn Ala Met Ser Ala Leu Tyr His Ile Ala Gln Asn 
 225                230                235                240
Glu Ser Pro Thr Leu Gln Ser Asn Glu Trp Ser Asp Tyr Phe Arg Asn 
                 245                250                255
Phe Val Asp Ser Cys Leu Gln Lys Ile Pro Gln Asp Arg Pro Thr Ser 
             260                265                270
Glu Glu Leu Leu Lys His Met Phe Val Leu Arg Glu Arg Pro Glu Thr 
         275                280                285
Val Leu Ile Asp Leu Ile Gln Arg Thr Lys Asp Ala Val Arg Glu Leu 
     290                295                300
Asp Asn Leu Gln Tyr Arg Lys Met Lys Lys Leu Leu Phe Gln Glu Ala 
 305                310                315                320
His Asn Gly Pro Ala Val Glu Ala Gln Glu Glu Glu Glu Glu Gln Asp 
                 325                330                335
His Gly Gly Gly Arg Thr Gly Thr Val Asn Ser Val Gly Ser Asn Gln 
             340                345                350
Ser Ile Pro Ser Met Ser Ile Ser Ala Ser Ser Gln Ser Ser Ser Val 
         355                360                365
Asn Ser Leu Pro Asp Ala Ser Asp Asp Lys Ser Glu Leu Asp Met Met 
     370                375                380
Glu Gly Asp His Thr Val Met Ser Asn Ser Ser Val Ile His Leu Lys 
 385                390                395                400
Pro Glu Glu Glu Asn Tyr Gln Glu Glu Gly Asp Pro Arg Thr Arg Ala 
                 405                410                415
Ser Ala Pro Gln Ser Pro Pro Gln Val Ser Arg His Lys Ser His Tyr 
             420                425                430
Arg Asn Arg Glu His Phe Ala Thr Ile Arg Thr Ala Ser Leu Val Thr 
         435                440                445
Arg Gln Met Gln Glu His Glu Gln Asp Ser Glu Leu Arg Glu Gln Met 
     450                455                460
Ser Gly Tyr Lys Arg Met Arg Arg Gln His Gln Lys Gln Leu Met Thr 
 465                470                475                480
Leu Glu Asn Lys Leu Lys Ala Glu Met Asp Glu His Arg Leu Arg Leu 
                 485                490                495
Asp Lys Asp Leu Glu Thr Gln Arg Asn Asn Phe Ala Ala Glu Met Glu 
             500                505                510
Lys Leu Ile Lys Lys His Gln Ala Ser Met Glu Lys Glu Ala Lys Val 
         515                520                525
Met Ala Asn Glu Glu Lys Lys Phe Gln Gln His Ile Gln Ala Gln Gln 
     530                535                540
Lys Lys Glu Leu Asn Ser Phe Leu Glu Ser Gln Lys Arg Glu Tyr Lys 
 545                550                555                560
Leu Arg Lys Glu Gln Leu Lys Glu Glu Leu Asn Glu Asn Gln Ser Thr 
                 565                570                575
Pro Lys Lys Glu Lys Gln Glu Trp Leu Ser Lys Gln Lys Glu Asn Ile 
             580                585                590
Gln His Phe Gln Ala Glu Glu Glu Ala Asn Leu Leu Arg Arg Gln Arg 
         595                600                605
Gln Tyr Leu Glu Leu Glu Cys Arg Arg Phe Lys Arg Arg Met Leu Leu 
     610                615                620
Gly Arg His Asn Leu Glu Gln Asp Leu Val Arg Glu Glu Leu Asn Lys 
 625                630                635                640
Arg Gln Thr Gln Lys Asp Leu Glu His Ala Met Leu Leu Arg Gln His 
                 645                650                655
Glu Ser Met Gln Glu Leu Glu Phe Arg His Leu Asn Thr Ile Gln Lys 
             660                665                670
Met Arg Cys Glu Leu Ile Arg Leu Gln His Gln Thr Glu Leu Thr Asn 
         675                680                685
Gln Leu Glu Tyr Asn Lys Arg Arg Glu Arg Glu Leu Arg Arg Lys His 
     690                695                700
Val Met Glu Val Arg Gln Gln Pro Lys Ser Leu Lys Ser Lys Glu Leu 
 705                710                715                720
Gln Ile Lys Lys Gln Phe Gln Asp Thr Cys Lys Ile Gln Thr Arg Gln 
                 725                730                735
Tyr Lys Ala Leu Arg Asn His Leu Leu Glu Thr Thr Pro Lys Ser Glu 
             740                745                750
His Lys Ala Val Leu Lys Arg Leu Lys Glu Glu Gln Thr Arg Lys Leu 
         755                760                765
Ala Ile Leu Ala Glu Gln Tyr Asp His Ser Ile Asn Glu Met Leu Ser 
     770                775                780
Thr Gln Ala Leu Arg Leu Asp Glu Ala Gln Glu Ala Glu Cys Gln Val 
 785                790                795                800
Leu Lys Met Gln Leu Gln Gln Glu Leu Glu Leu Leu Asn Ala Tyr Gln 
                 805                810                815
Ser Lys Ile Lys Met Gln Ala Glu Ala Gln His Asp Arg Glu Leu Arg 
             820                825                830
Glu Leu Glu Gln Arg Val Ser Leu Arg Arg Ala Leu Leu Glu Gln Lys 
         835                840                845
Ile Glu Glu Glu Met Leu Ala Leu Gln Asn Glu Arg Thr Glu Arg Ile 
     850                855                860
Arg Ser Leu Leu Glu Arg Gln Ala Arg Glu Ile Glu Ala Phe Asp Ser 
 865                870                875                880
Glu Ser Met Arg Leu Gly Phe Ser Asn Met Val Leu Ser Asn Leu Ser 
                 885                890                895
Pro Glu Ala Phe Ser His Ser Tyr Pro Gly Ala Ser Ser Trp Ser His 
             900                905                910
Asn Pro Thr Gly Gly Ser Gly Pro His Trp Gly His Pro Met Gly Gly 
         915                920                925
Thr Pro Gln Ala Trp Gly His Pro Met Gln Gly Gly Pro Gln Pro Trp 
     930                935                940
Gly His Pro Ser Gly Pro Met Gln Gly Val Pro Arg Gly Ser Ser Ile 
 945                950                955                960
Gly Val Arg Asn Ser Pro Gln Ala Leu Arg Arg Thr Ala Ser Gly Gly 
                 965                970                975
Arg Thr Glu Gln Gly Met Ser Arg Ser Thr Ser Val Thr Ser Gln Ile 
             980                985                990
Ser Asn Gly Ser His Met Ser Tyr Thr 
         995                1000



<210> 1171
<211> 1001
<212> PRT
<213> Homo sapiens
<308> XP_030845
<400> 1171

Met Pro Ser Thr Asn Arg Ala Gly Ser Leu Lys Asp Pro Glu Ile Ala 
  1               5                  10                  15
Glu Leu Phe Phe Lys Glu Asp Pro Glu Lys Leu Phe Thr Asp Leu Arg 
             20                  25                  30
Glu Ile Gly His Gly Ser Phe Gly Ala Val Tyr Phe Ala Arg Asp Val 
         35                  40                  45
Arg Thr Asn Glu Val Val Ala Ile Lys Lys Met Ser Tyr Ser Gly Lys 
     50                  55                  60
Gln Ser Thr Glu Lys Trp Gln Asp Ile Ile Lys Glu Val Lys Phe Leu 
 65                  70                  75                  80
Gln Arg Ile Lys His Pro Asn Ser Ile Glu Tyr Lys Gly Cys Tyr Leu 
                 85                  90                  95
Arg Glu His Thr Ala Trp Leu Val Met Glu Tyr Cys Leu Gly Ser Ala 
             100                105                110
Ser Asp Leu Leu Glu Val His Lys Lys Pro Leu Gln Glu Val Glu Ile 
         115                120                125
Ala Ala Ile Thr His Gly Ala Leu Gln Gly Leu Ala Tyr Leu His Ser 
     130                135                140
His Thr Met Ile His Arg Asp Ile Lys Ala Gly Asn Ile Leu Leu Thr 
 145                150                155                160
Glu Pro Gly Gln Val Lys Leu Ala Asp Phe Gly Ser Ala Ser Met Ala 
                 165                170                175
Ser Pro Ala Asn Ser Phe Val Gly Thr Pro Tyr Trp Met Ala Pro Glu 
             180                185                190
Val Ile Leu Ala Met Asp Glu Gly Gln Tyr Asp Gly Lys Val Asp Val 
         195                200                205
Trp Ser Leu Gly Ile Thr Cys Ile Glu Leu Ala Glu Arg Lys Pro Pro 
     210                215                220
Leu Phe Asn Met Asn Ala Met Ser Ala Leu Tyr His Ile Ala Gln Asn 
 225                230                235                240
Glu Ser Pro Thr Leu Gln Ser Asn Glu Trp Ser Asp Tyr Phe Arg Asn 
                 245                250                255
Phe Val Asp Ser Cys Leu Gln Lys Ile Pro Gln Asp Arg Pro Thr Ser 
             260                265                270
Glu Glu Leu Leu Lys His Ile Phe Val Leu Arg Glu Arg Pro Glu Thr 
         275                280                285
Val Leu Ile Asp Leu Ile Gln Arg Thr Lys Asp Ala Val Arg Glu Leu 
     290                295                300
Asp Asn Leu Gln Tyr Arg Lys Met Lys Lys Leu Leu Phe Gln Glu Ala 
 305                310                315                320
His Asn Gly Pro Ala Val Glu Ala Gln Glu Glu Glu Glu Glu Gln Asp 
                 325                330                335
His Gly Val Gly Arg Thr Gly Thr Val Asn Ser Val Gly Ser Asn Gln 
             340                345                350
Ser Ile Pro Ser Met Ser Ile Ser Ala Ser Ser Gln Ser Ser Ser Val 
         355                360                365
Asn Ser Leu Pro Asp Val Ser Asp Asp Lys Ser Glu Leu Asp Met Met 
     370                375                380
Glu Gly Asp His Thr Val Met Ser Asn Ser Ser Val Ile His Leu Lys 
 385                390                395                400
Pro Glu Glu Glu Asn Tyr Arg Glu Glu Gly Asp Pro Arg Thr Arg Ala 
                 405                410                415
Ser Asp Pro Gln Ser Pro Pro Gln Val Ser Arg His Lys Ser His Tyr 
             420                425                430
Arg Asn Arg Glu His Phe Ala Thr Ile Arg Thr Ala Ser Leu Val Thr 
         435                440                445
Arg Gln Met Gln Glu His Glu Gln Asp Ser Glu Leu Arg Glu Gln Met 
     450                455                460
Ser Gly Tyr Lys Arg Met Arg Arg Gln His Gln Lys Gln Leu Met Thr 
 465                470                475                480
Leu Glu Asn Lys Leu Lys Ala Glu Met Asp Glu His Arg Leu Arg Leu 
                 485                490                495
Asp Lys Asp Leu Glu Thr Gln Arg Asn Asn Phe Ala Ala Glu Met Glu 
             500                505                510
Lys Leu Ile Lys Lys His Gln Ala Ala Met Glu Lys Glu Ala Lys Val 
         515                520                525
Met Ser Asn Glu Glu Lys Lys Phe Gln Gln His Ile Gln Ala Gln Gln 
     530                535                540
Lys Lys Glu Leu Asn Ser Phe Leu Glu Ser Gln Lys Arg Glu Tyr Lys 
 545                550                555                560
Leu Arg Lys Glu Gln Leu Lys Glu Glu Leu Asn Glu Asn Gln Ser Thr 
                 565                570                575
Pro Lys Lys Glu Lys Gln Glu Trp Leu Ser Lys Gln Lys Glu Asn Ile 
             580                585                590
Gln His Phe Gln Ala Glu Glu Glu Ala Asn Leu Leu Arg Arg Gln Arg 
         595                600                605
Gln Tyr Leu Glu Leu Glu Cys Arg Arg Phe Lys Arg Arg Met Leu Leu 
     610                615                620
Gly Arg His Asn Leu Glu Gln Asp Leu Val Arg Glu Glu Leu Asn Lys 
 625                630                635                640
Arg Gln Thr Gln Lys Asp Leu Glu His Ala Met Leu Leu Arg Gln His 
                 645                650                655
Glu Ser Met Gln Glu Leu Glu Phe Arg His Leu Asn Thr Ile Gln Lys 
             660                665                670
Met Arg Cys Glu Leu Ile Arg Leu Gln His Gln Thr Glu Leu Thr Asn 
         675                680                685
Gln Leu Glu Tyr Asn Lys Arg Arg Glu Arg Glu Leu Arg Arg Lys His 
     690                695                700
Val Met Glu Val Arg Gln Gln Pro Lys Ser Leu Lys Ser Lys Glu Leu 
 705                710                715                720
Gln Ile Lys Lys Gln Phe Gln Asp Thr Cys Lys Ile Gln Thr Arg Gln 
                 725                730                735
Tyr Lys Ala Leu Arg Asn His Leu Leu Glu Thr Thr Pro Lys Ser Glu 
             740                745                750
His Lys Ala Val Leu Lys Arg Leu Lys Glu Glu Gln Thr Arg Lys Leu 
         755                760                765
Ala Ile Leu Ala Glu Gln Tyr Asp His Ser Ile Asn Glu Met Leu Ser 
     770                775                780
Thr Gln Ala Leu Arg Leu Asp Glu Ala Gln Glu Ala Glu Cys Gln Val 
 785                790                795                800
Leu Lys Met Gln Leu Gln Gln Glu Leu Glu Leu Leu Asn Ala Tyr Gln 
                 805                810                815
Ser Lys Ile Lys Met Gln Ala Glu Ala Gln His Asp Arg Glu Leu Arg 
             820                825                830
Glu Leu Glu Gln Arg Val Ser Leu Arg Arg Ala Leu Leu Glu Gln Lys 
         835                840                845
Ile Glu Glu Glu Met Leu Ala Leu Gln Asn Glu Arg Thr Glu Arg Ile 
     850                855                860
Arg Ser Leu Leu Glu Arg Gln Ala Arg Glu Ile Glu Ala Phe Asp Ser 
 865                870                875                880
Glu Ser Met Arg Leu Gly Phe Ser Asn Met Val Leu Ser Asn Leu Ser 
                 885                890                895
Pro Glu Ala Phe Ser His Ser Tyr Pro Gly Ala Ser Gly Trp Ser His 
             900                905                910
Asn Pro Thr Gly Gly Pro Gly Pro His Trp Gly His Pro Met Gly Gly 
         915                920                925
Pro Pro Gln Ala Trp Gly His Pro Met Gln Gly Gly Pro Gln Pro Trp 
     930                935                940
Gly His Pro Ser Gly Pro Met Gln Gly Val Pro Arg Gly Ser Ser Met 
 945                950                955                960
Gly Val Arg Asn Ser Pro Gln Ala Leu Arg Arg Thr Ala Ser Gly Gly 
                 965                970                975
Arg Thr Glu Gln Gly Met Ser Arg Ser Thr Ser Val Thr Ser Gln Ile 
             980                985                990
Ser Asn Gly Ser His Met Ser Tyr Thr 
         995                1000



<210> 1172
<211> 3236
<212> DNA
<213> Rattus norvegicus
<308> AF085693
<400> 1172

gcccgcgcc  cccacgctg  cccagaggg  tgcggccgc  tcgccgctg  ggatgtccc  60
gaaggggcc  cgagcggag  tgtgtgcgg  ctgcagcgc  cctgaccct  gctgggcat  120
tatcagcag  ggtgtgctg  tttgtgacg  gtgctgcag  gtgcaccgg  gcctgggac  180
acacatctc  attgtcaaa  accttcgcc  cagcgcctg  cctcctacg  tgctacaga  240
ggtgcacac  cttgccagc  acggggcca  ctctatctg  gagcattcc  tgctggacc  300
tgcacaagt  caaagtggc  ggcgcaaag  caaccccca  gacaaagtc  accccatca  360
gtcagagtt  atcagggca  agtaccaga  gctggcgtt  gtgcacaag  ttccctgcc  420
tgatgatga  ggggtcacc  ccaaagacc  cagcaagca  ctgcactcg  gtgtgcgaa  480
aggcaacct  gagacctgt  tgcgcctgc  ttccctggg  gcccaggcc  acttcttcc  540
cccagaaaa  ggcactaca  ctctacacg  ggctgccaa  gcagggcag  cactgcagg  600
tgagctgct  gtagtgtat  gggctgacc  aggctcccc  gatgtcaat  gccgcacac  660
cattgacta  gccaggcag  cggggcacc  tgaactggc  gaaaggcta  ttgagtgcc  720
gtatgagct  actgaccgg  tggccttct  cctctgtgg  cggaagcct  atcacaaga  780
tgggcatta  atcatacca  agatggctg  cagatctcg  caaaagtgc  tgtctcaga  840
tttggatct  tctgaattg  ccaaagctg  caagaagaa  ctacaagca  tcagcaacc  900
gctctttga  gagctcgcc  tggatgtgt  tgacgaagt  gaccggaga  aaaatgatg  960
agtgtggct  gctacccag  atcatagca  cctggtgac  gaacgcagt  ctgtgccct  1020
cctgccagt  aaccctgaa  actcagcca  tcggaatca  ggacgacag  aattggctc  1080
ttttaatgc  cgagagttt  ccaccttga  catcgacat  ctcagtgag  ccaaacgga  1140
gcagcaggg  aagagtctg  gcagcccca  agacaacct  gagctgtct  cacggaacc  1200
aagtgacct  gacgaccag  acgactacg  tagtgtggc  tctgacgaa  acacagacc  1260
ggagccctt  cccagtgct  gcgccacgc  gaacaatcg  gccaggagc  tggactcct  1320
agatctgtc  gatggggct  tgacgctgc  ggagtacct  gagctgaag  aggctctgg  1380
tacctccga  gccaaagtg  agcagctca  gaaagtcaa  agcagtctg  gtgacgagc  1440
tcggaagct  cagagggag  tccacaaac  gcaggcaga  aacctgcag  tccggcagc  1500
accaggacc  gtgcctgta  cctcacttc  cagtgaacg  gcagaacac  cactcatgg  1560
ccctggtgg  agtacccat  gcagggacc  ccaggcctt  tctatgtat  agccaggct  1620
cgccctgaa  ccctttgga  gtgcacctg  ggatgagct  gccacacgg  tccagcctt  1680
ccacagcac  gagctggaa  atgatgcca  ctattcagt  catgtccct  ctggccttt  1740
ccggatccg  aagggggtg  ctgcctctt  tgtgacctt  actccctcc  ccccactgc  1800
gtcaagctc  caagaagga  gtcgccatg  gagcaagct  tcacgccac  gcagtggcg  1860
agagagtga  tatgagaac  cacagagtg  agagcctct  ctgggactt  aagggaagc  1920
attcctaga  ctgagcaag  aggatgagc  gcacgctga  ctggagagc  tagatggag  1980
cccagaccc  gggctcccc  gcacagaag  tgtcatcct  aagacagag  aggtcacca  2040
gaacattca  gagctattg  gggcagccc  ggagttcaa  catgacagc  ttgtgccct  2100
ttcagaaaa  atccatttg  ctgtgactg  gatggcctc  ctcttccca  agaggccag  2160
cctggagcc  gtgcgcagt  cactgcggc  gctcaacgc  agcgcctac  ggctgcaga  2220
tgaatgccg  aagacagtg  ctccagaac  tggcgcccc  gtggacttc  agctactga  2280
tcagcaggt  atccagtgc  cctatgaca  cgccaaggc  gccaagcag  tggtcacca  2340
caccacccg  gagaagaaa  agtgaccac  ttccctgcc  ttacccaca  cctgggacc  2400
cactggcca  gggagctgg  ccactccag  cactaaccc  cccccaaca  agccactgg  2460
acaagtgcc  ttagtgcca  cattctcct  tggcatcca  gtgccctgg  gtccacacc  2520
ccttaagcc  caaggatgg  aatgtgagg  gacaggacc  tctgtcccc  acattccac  2580
cccctccct  tgtacatag  atccctgcc  tgctgatac  caggagcct  aaggagtcc  2640
tcccagctc  tcacctgcc  tccagggcc  cctcagcaa  gggtgggac  gggacactc  2700
aagtggggc  gccccgcct  ctgcaccct  tccccatga  ccagttcag  cctgggggg  2760
cgagcagag  caccccctc  tttgtgcat  atctmtggg  gtytytgcc  cgtagccag  2820
agccccccc  ctgctcttt  atgacaaat  gcccctgcc  gagcacagg  cccaacttg  2880
gtgccaggg  ccccagcag  aaacactgg  acgtctttc  ctcccctac  ccttaattt  2940
aactttgtg  taactgagt  tccctgcgt  cttacaact  agtgtgtga  cggcagtgc  3000
gtgccagag  cctggtcca  ctggagctc  gaggggcag  ggaaccaga  tagtgggac  3060
agcattgga  gtcagcttc  ctctaccca  cctgggacg  ggactgtca  ggtcaccag  3120
tgtggtcca  ttgctaccc  tacttgtat  cctatccta  aaacttaaa  ggaaaacca  3180
ttccctcca  ctctcccca  cccctgtgg  aagtgtgct  accaggcag  ggacag  3236



<210> 1173
<211> 770
<212> PRT
<213> Rattus norvegicus
<308> Q9Z272
<400> 1173

Met Ser Arg Lys Gly Pro Arg Ala Glu Val Cys Ala Asp Cys Ser Ala 
  1               5                  10                  15
Pro Asp Pro Gly Trp Ala Ser Ile Ser Arg Gly Val Leu Val Cys Asp 
             20                  25                  30
Glu Cys Cys Ser Val His Arg Ser Leu Gly Arg His Ile Ser Ile Val 
         35                  40                  45
Lys His Leu Arg His Ser Ala Trp Pro Pro Thr Leu Leu Gln Met Val 
     50                  55                  60
His Thr Leu Ala Ser Asn Gly Ala Asn Ser Ile Trp Glu His Ser Leu 
 65                  70                  75                  80
Leu Asp Pro Ala Gln Val Gln Ser Gly Arg Arg Lys Ala Asn Pro Gln 
                 85                  90                  95
Asp Lys Val His Pro Ile Lys Ser Glu Phe Ile Arg Ala Lys Tyr Gln 
             100                105                110
Met Leu Ala Phe Val His Lys Leu Pro Cys Arg Asp Asp Asp Gly Val 
         115                120                125
Thr Ala Lys Asp Leu Ser Lys Gln Leu His Ser Ser Val Arg Thr Gly 
     130                135                140
Asn Leu Glu Thr Cys Leu Arg Leu Leu Ser Leu Gly Ala Gln Ala Asn 
 145                150                155                160
Phe Phe His Pro Glu Lys Gly Thr Thr Pro Leu His Val Ala Ala Lys 
                 165                170                175
Ala Gly Gln Thr Leu Gln Ala Glu Leu Leu Val Val Tyr Gly Ala Asp 
             180                185                190
Pro Gly Ser Pro Asp Val Asn Gly Arg Thr Pro Ile Asp Tyr Ala Arg 
         195                200                205
Gln Ala Gly His His Glu Leu Ala Glu Arg Leu Val Glu Cys Gln Tyr 
     210                215                220
Glu Leu Thr Asp Arg Leu Ala Phe Tyr Leu Cys Gly Arg Lys Pro Asp 
 225                230                235                240
His Lys Asn Gly His Tyr Ile Ile Pro Gln Met Ala Asp Arg Ser Arg 
                 245                250                255
Gln Lys Cys Met Ser Gln Ser Leu Asp Leu Ser Glu Leu Ala Lys Ala 
             260                265                270
Ala Lys Lys Lys Leu Gln Ala Leu Ser Asn Arg Leu Phe Glu Glu Leu 
         275                280                285
Ala Met Asp Val Tyr Asp Glu Val Asp Arg Arg Glu Asn Asp Ala Val 
     290                295                300
Trp Leu Ala Thr Gln Asn His Ser Thr Leu Val Thr Glu Arg Ser Ala 
 305                310                315                320
Val Pro Phe Leu Pro Val Asn Pro Glu Tyr Ser Ala Thr Arg Asn Gln 
                 325                330                335
Gly Arg Gln Lys Leu Ala Arg Phe Asn Ala Arg Glu Phe Ala Thr Leu 
             340                345                350
Ile Ile Asp Ile Leu Ser Glu Ala Lys Arg Arg Gln Gln Gly Lys Ser 
         355                360                365
Leu Ser Ser Pro Thr Asp Asn Leu Glu Leu Ser Ala Arg Asn Gln Ser 
     370                375                380
Asp Leu Asp Asp Gln His Asp Tyr Asp Ser Val Ala Ser Asp Glu Asp 
 385                390                395                400
Thr Asp Gln Glu Pro Leu Pro Ser Ala Gly Ala Thr Arg Asn Asn Arg 
                 405                410                415
Ala Arg Ser Met Asp Ser Ser Asp Leu Ser Asp Gly Ala Val Thr Leu 
             420                425                430
Gln Glu Tyr Leu Glu Leu Lys Lys Ala Leu Ala Thr Ser Glu Ala Lys 
         435                440                445
Val Gln Gln Leu Met Lys Val Asn Ser Ser Leu Ser Asp Glu Leu Arg 
     450                455                460
Lys Leu Gln Arg Glu Ile His Lys Leu Gln Ala Glu Asn Leu Gln Leu 
 465                470                475                480
Arg Gln Pro Pro Gly Pro Val Pro Val Pro Ser Leu Pro Ser Glu Arg 
                 485                490                495
Ala Glu His Thr Leu Met Gly Pro Gly Gly Ser Thr His Arg Arg Asp 
             500                505                510
Arg Gln Ala Phe Ser Met Tyr Glu Pro Gly Ser Ala Leu Lys Pro Phe 
         515                520                525
Gly Gly Ala Pro Gly Asp Glu Leu Ala Thr Arg Leu Gln Pro Phe His 
     530                535                540
Ser Thr Glu Leu Glu Asp Asp Ala Ile Tyr Ser Val His Val Pro Ala 
 545                550                555                560
Gly Leu Tyr Arg Ile Arg Lys Gly Val Ser Ala Ser Ser Val Thr Phe 
                 565                570                575
Thr Pro Ser Ser Pro Leu Leu Ser Ser Ser Gln Glu Gly Ser Arg His 
             580                585                590
Ala Ser Lys Leu Ser Arg His Gly Ser Gly Ala Glu Ser Asp Tyr Glu 
         595                600                605
Asn Thr Gln Ser Gly Glu Pro Leu Leu Gly Leu Glu Gly Lys Arg Phe 
     610                615                620
Leu Glu Leu Ser Lys Glu Asp Glu Leu His Ala Glu Leu Glu Ser Leu 
 625                630                635                640
Asp Gly Asp Pro Asp Pro Gly Leu Pro Ser Thr Glu Asp Val Ile Leu 
                 645                650                655
Lys Thr Glu Gln Val Thr Lys Asn Ile Gln Glu Leu Leu Arg Ala Ala 
             660                665                670
Gln Glu Phe Lys His Asp Ser Phe Val Pro Cys Ser Glu Lys Ile His 
         675                680                685
Leu Ala Val Thr Glu Met Ala Ser Leu Phe Pro Lys Arg Pro Ala Leu 
     690                695                700
Glu Pro Val Arg Ser Ser Leu Arg Leu Leu Asn Ala Ser Ala Tyr Arg 
 705                710                715                720
Leu Gln Ser Glu Cys Arg Lys Thr Val Pro Pro Glu Pro Gly Ala Pro 
                 725                730                735
Val Asp Phe Gln Leu Leu Thr Gln Gln Val Ile Gln Cys Ala Tyr Asp 
             740                745                750
Ile Ala Lys Ala Ala Lys Gln Leu Val Thr Ile Thr Thr Arg Glu Lys 
         755                760                765
Lys Gln 
     770



<210> 1174
<211> 497
<212> DNA
<213> Homo sapiens
<308> BG984848
<400> 1174

aagactctc  aggatcccc  ccgagatgg  ctccctctt  ccaaaggta  aggtttcaa  60
gagaggacc  ggagtggga  ggcctcgag  tgggtcagg  gtggagaat  ccatctgat  120
gctacctgg  tggagacac  gacaaactg  gccctgatc  cagctggcg  cttaaagtc  180
aaggtccag  ctcactcct  ccccctcca  aggccagcc  tggagccag  gcggagctc  240
ctgcggctg  tcaacgcca  cgcctaccg  ctgcagagt  agtgccgga  gacagtgcc  300
ccagagccc  gcgccccag  ggacttcca  ctgccgact  agcaggtga  ccagtgcgc  360
tatgacatc  ccaaggctg  caagcagct  gtcaccatc  ccacccgag  gaagaagca  420
tgacctctc  ccccacacc  tcacctgca  cctaggacc  cactggcca  aggagctgg  480
ccactccag  ctctggg  497



<210> 1175
<211> 761
<212> PRT
<213> Homo sapiens
<308> NP_054749
<400> 1175

Met Ser Arg Lys Gly Pro Arg Ala Glu Val Cys Ala Asp Cys Ser Ala 
  1               5                  10                  15
Pro Asp Pro Gly Trp Ala Ser Ile Ser Arg Gly Val Leu Val Cys Asp 
             20                  25                  30
Glu Cys Cys Ser Val His Arg Ser Leu Gly Arg His Ile Ser Ile Val 
         35                  40                  45
Lys His Leu Arg His Ser Ala Trp Pro Pro Thr Leu Leu Gln Met Val 
     50                  55                  60
His Thr Leu Ala Ser Asn Gly Ala Asn Ser Ile Trp Glu His Ser Leu 
 65                  70                  75                  80
Leu Asp Pro Ala Gln Val Gln Ser Gly Arg Arg Lys Ala Asn Pro Gln 
                 85                  90                  95
Asp Lys Val His Pro Ile Lys Ser Glu Phe Ile Arg Ala Lys Tyr Gln 
             100                105                110
Met Leu Ala Phe Val His Lys Leu Ser Cys Arg Asp Asp Asp Gly Val 
         115                120                125
Thr Ala Lys Asp Leu Ser Lys Gln Leu His Ser Ser Val Arg Thr Gly 
     130                135                140
Asn Leu Glu Thr Cys Leu Arg Leu Leu Ser Leu Gly Ala Gln Ala Asn 
 145                150                155                160
Phe Phe His Pro Glu Lys Gly Thr Thr Pro Leu His Val Ala Ala Lys 
                 165                170                175
Ala Gly Gln Thr Leu Gln Ala Glu Leu Leu Val Val Tyr Gly Ala Asp 
             180                185                190
Pro Gly Ser Pro Asp Val Asn Gly Arg Thr Pro Ile Asp Tyr Ala Arg 
         195                200                205
Gln Ala Gly His His Glu Leu Ala Glu Arg Leu Val Glu Cys Gln Tyr 
     210                215                220
Glu Leu Thr Asp Arg Leu Ala Phe Tyr Leu Cys Gly Arg Lys Pro Asp 
 225                230                235                240
His Lys Asn Gly His Tyr Ile Ile Pro Gln Met Ala Asp Ser Leu Asp 
                 245                250                255
Leu Ser Glu Leu Ala Lys Ala Ala Lys Lys Lys Leu Gln Ala Leu Ser 
             260                265                270
Asn Arg Leu Phe Glu Glu Leu Ala Met Asp Val Tyr Asp Glu Val Asp 
         275                280                285
Arg Arg Glu Asn Asp Ala Val Trp Leu Ala Thr Gln Asn His Ser Thr 
     290                295                300
Leu Val Thr Glu Arg Ser Ala Val Pro Phe Leu Pro Val Asn Pro Glu 
 305                310                315                320
Tyr Ser Ala Thr Arg Asn Gln Gly Arg Gln Lys Leu Ala Arg Phe Asn 
                 325                330                335
Ala Arg Glu Phe Ala Thr Leu Ile Ile Asp Ile Leu Ser Glu Ala Lys 
             340                345                350
Arg Arg Gln Gln Gly Lys Ser Leu Ser Ser Pro Thr Asp Asn Leu Glu 
         355                360                365
Leu Ser Leu Arg Ser Gln Ser Asp Leu Asp Asp Gln His Asp Tyr Asp 
     370                375                380
Ser Val Ala Ser Asp Glu Asp Thr Asp Gln Glu Pro Leu Arg Ser Thr 
 385                390                395                400
Gly Ala Thr Arg Ser Asn Arg Ala Arg Ser Met Asp Ser Ser Asp Leu 
                 405                410                415
Ser Asp Gly Ala Val Thr Leu Gln Glu Tyr Leu Glu Leu Lys Lys Ala 
             420                425                430
Leu Ala Thr Ser Glu Ala Lys Val Gln Gln Leu Met Lys Val Asn Ser 
         435                440                445
Ser Leu Ser Asp Glu Leu Arg Arg Leu Gln Arg Glu Ile His Lys Leu 
     450                455                460
Gln Ala Glu Asn Leu Gln Leu Arg Gln Pro Pro Gly Pro Val Pro Thr 
 465                470                475                480
Pro Pro Leu Pro Ser Glu Arg Ala Glu His Thr Pro Met Ala Pro Gly 
                 485                490                495
Gly Ser Thr His Arg Arg Asp Arg Gln Ala Phe Ser Met Tyr Glu Pro 
             500                505                510
Gly Ser Ala Leu Lys Pro Phe Gly Gly Pro Pro Gly Asp Glu Leu Thr 
         515                520                525
Thr Arg Leu Gln Pro Phe His Ser Thr Glu Leu Glu Asp Asp Ala Ile 
     530                535                540
Tyr Ser Val His Val Pro Ala Gly Leu Tyr Arg Ile Arg Lys Gly Val 
 545                550                555                560
Ser Ala Ser Ala Val Pro Phe Thr Pro Ser Ser Pro Leu Leu Ser Cys 
                 565                570                575
Ser Gln Glu Gly Ser Arg His Thr Ser Lys Leu Ser Arg His Gly Ser 
             580                585                590
Gly Ala Asp Ser Asp Tyr Glu Asn Thr Gln Ser Gly Asp Pro Leu Leu 
         595                600                605
Gly Leu Glu Gly Lys Arg Phe Leu Glu Leu Gly Lys Glu Glu Asp Phe 
     610                615                620
His Pro Glu Leu Glu Ser Leu Asp Gly Asp Leu Asp Pro Gly Leu Pro 
 625                630                635                640
Ser Thr Glu Asp Val Ile Leu Lys Thr Glu Gln Val Thr Lys Asn Ile 
                 645                650                655
Gln Glu Leu Leu Arg Ala Ala Gln Glu Phe Lys His Asp Ser Phe Val 
             660                665                670
Pro Cys Ser Glu Lys Ile His Leu Ala Val Thr Glu Met Ala Ser Leu 
         675                680                685
Phe Pro Lys Arg Pro Ala Leu Glu Pro Val Arg Ser Ser Leu Arg Leu 
     690                695                700
Leu Asn Ala Ser Ala Tyr Arg Leu Gln Ser Glu Cys Arg Lys Thr Val 
 705                710                715                720
Pro Pro Glu Pro Gly Ala Pro Val Asp Phe Gln Leu Leu Thr Gln Gln 
                 725                730                735
Val Ile Gln Cys Ala Tyr Asp Ile Ala Lys Ala Ala Lys Gln Leu Val 
             740                745                750
Thr Ile Thr Thr Arg Glu Lys Lys Gln 
         755                760



<210> 1176
<211> 3236
<212> DNA
<213> Rattus norvegicus
<308> AF085693
<400> 1176

gcccgcgcc  cccacgctg  cccagaggg  tgcggccgc  tcgccgctg  ggatgtccc  60
gaaggggcc  cgagcggag  tgtgtgcgg  ctgcagcgc  cctgaccct  gctgggcat  120
tatcagcag  ggtgtgctg  tttgtgacg  gtgctgcag  gtgcaccgg  gcctgggac  180
acacatctc  attgtcaaa  accttcgcc  cagcgcctg  cctcctacg  tgctacaga  240
ggtgcacac  cttgccagc  acggggcca  ctctatctg  gagcattcc  tgctggacc  300
tgcacaagt  caaagtggc  ggcgcaaag  caaccccca  gacaaagtc  accccatca  360
gtcagagtt  atcagggca  agtaccaga  gctggcgtt  gtgcacaag  ttccctgcc  420
tgatgatga  ggggtcacc  ccaaagacc  cagcaagca  ctgcactcg  gtgtgcgaa  480
aggcaacct  gagacctgt  tgcgcctgc  ttccctggg  gcccaggcc  acttcttcc  540
cccagaaaa  ggcactaca  ctctacacg  ggctgccaa  gcagggcag  cactgcagg  600
tgagctgct  gtagtgtat  gggctgacc  aggctcccc  gatgtcaat  gccgcacac  660
cattgacta  gccaggcag  cggggcacc  tgaactggc  gaaaggcta  ttgagtgcc  720
gtatgagct  actgaccgg  tggccttct  cctctgtgg  cggaagcct  atcacaaga  780
tgggcatta  atcatacca  agatggctg  cagatctcg  caaaagtgc  tgtctcaga  840
tttggatct  tctgaattg  ccaaagctg  caagaagaa  ctacaagca  tcagcaacc  900
gctctttga  gagctcgcc  tggatgtgt  tgacgaagt  gaccggaga  aaaatgatg  960
agtgtggct  gctacccag  atcatagca  cctggtgac  gaacgcagt  ctgtgccct  1020
cctgccagt  aaccctgaa  actcagcca  tcggaatca  ggacgacag  aattggctc  1080
ttttaatgc  cgagagttt  ccaccttga  catcgacat  ctcagtgag  ccaaacgga  1140
gcagcaggg  aagagtctg  gcagcccca  agacaacct  gagctgtct  cacggaacc  1200
aagtgacct  gacgaccag  acgactacg  tagtgtggc  tctgacgaa  acacagacc  1260
ggagccctt  cccagtgct  gcgccacgc  gaacaatcg  gccaggagc  tggactcct  1320
agatctgtc  gatggggct  tgacgctgc  ggagtacct  gagctgaag  aggctctgg  1380
tacctccga  gccaaagtg  agcagctca  gaaagtcaa  agcagtctg  gtgacgagc  1440
tcggaagct  cagagggag  tccacaaac  gcaggcaga  aacctgcag  tccggcagc  1500
accaggacc  gtgcctgta  cctcacttc  cagtgaacg  gcagaacac  cactcatgg  1560
ccctggtgg  agtacccat  gcagggacc  ccaggcctt  tctatgtat  agccaggct  1620
cgccctgaa  ccctttgga  gtgcacctg  ggatgagct  gccacacgg  tccagcctt  1680
ccacagcac  gagctggaa  atgatgcca  ctattcagt  catgtccct  ctggccttt  1740
ccggatccg  aagggggtg  ctgcctctt  tgtgacctt  actccctcc  ccccactgc  1800
gtcaagctc  caagaagga  gtcgccatg  gagcaagct  tcacgccac  gcagtggcg  1860
agagagtga  tatgagaac  cacagagtg  agagcctct  ctgggactt  aagggaagc  1920
attcctaga  ctgagcaag  aggatgagc  gcacgctga  ctggagagc  tagatggag  1980
cccagaccc  gggctcccc  gcacagaag  tgtcatcct  aagacagag  aggtcacca  2040
gaacattca  gagctattg  gggcagccc  ggagttcaa  catgacagc  ttgtgccct  2100
ttcagaaaa  atccatttg  ctgtgactg  gatggcctc  ctcttccca  agaggccag  2160
cctggagcc  gtgcgcagt  cactgcggc  gctcaacgc  agcgcctac  ggctgcaga  2220
tgaatgccg  aagacagtg  ctccagaac  tggcgcccc  gtggacttc  agctactga  2280
tcagcaggt  atccagtgc  cctatgaca  cgccaaggc  gccaagcag  tggtcacca  2340
caccacccg  gagaagaaa  agtgaccac  ttccctgcc  ttacccaca  cctgggacc  2400
cactggcca  gggagctgg  ccactccag  cactaaccc  cccccaaca  agccactgg  2460
acaagtgcc  ttagtgcca  cattctcct  tggcatcca  gtgccctgg  gtccacacc  2520
ccttaagcc  caaggatgg  aatgtgagg  gacaggacc  tctgtcccc  acattccac  2580
cccctccct  tgtacatag  atccctgcc  tgctgatac  caggagcct  aaggagtcc  2640
tcccagctc  tcacctgcc  tccagggcc  cctcagcaa  gggtgggac  gggacactc  2700
aagtggggc  gccccgcct  ctgcaccct  tccccatga  ccagttcag  cctgggggg  2760
cgagcagag  caccccctc  tttgtgcat  atctmtggg  gtytytgcc  cgtagccag  2820
agccccccc  ctgctcttt  atgacaaat  gcccctgcc  gagcacagg  cccaacttg  2880
gtgccaggg  ccccagcag  aaacactgg  acgtctttc  ctcccctac  ccttaattt  2940
aactttgtg  taactgagt  tccctgcgt  cttacaact  agtgtgtga  cggcagtgc  3000
gtgccagag  cctggtcca  ctggagctc  gaggggcag  ggaaccaga  tagtgggac  3060
agcattgga  gtcagcttc  ctctaccca  cctgggacg  ggactgtca  ggtcaccag  3120
tgtggtcca  ttgctaccc  tacttgtat  cctatccta  aaacttaaa  ggaaaacca  3180
ttccctcca  ctctcccca  cccctgtgg  aagtgtgct  accaggcag  ggacag  3236



<210> 1177
<211> 770
<212> PRT
<213> Rattus norvegicus
<308> Q9Z272
<400> 1177

Met Ser Arg Lys Gly Pro Arg Ala Glu Val Cys Ala Asp Cys Ser Ala 
  1               5                  10                  15
Pro Asp Pro Gly Trp Ala Ser Ile Ser Arg Gly Val Leu Val Cys Asp 
             20                  25                  30
Glu Cys Cys Ser Val His Arg Ser Leu Gly Arg His Ile Ser Ile Val 
         35                  40                  45
Lys His Leu Arg His Ser Ala Trp Pro Pro Thr Leu Leu Gln Met Val 
     50                  55                  60
His Thr Leu Ala Ser Asn Gly Ala Asn Ser Ile Trp Glu His Ser Leu 
 65                  70                  75                  80
Leu Asp Pro Ala Gln Val Gln Ser Gly Arg Arg Lys Ala Asn Pro Gln 
                 85                  90                  95
Asp Lys Val His Pro Ile Lys Ser Glu Phe Ile Arg Ala Lys Tyr Gln 
             100                105                110
Met Leu Ala Phe Val His Lys Leu Pro Cys Arg Asp Asp Asp Gly Val 
         115                120                125
Thr Ala Lys Asp Leu Ser Lys Gln Leu His Ser Ser Val Arg Thr Gly 
     130                135                140
Asn Leu Glu Thr Cys Leu Arg Leu Leu Ser Leu Gly Ala Gln Ala Asn 
 145                150                155                160
Phe Phe His Pro Glu Lys Gly Thr Thr Pro Leu His Val Ala Ala Lys 
                 165                170                175
Ala Gly Gln Thr Leu Gln Ala Glu Leu Leu Val Val Tyr Gly Ala Asp 
             180                185                190
Pro Gly Ser Pro Asp Val Asn Gly Arg Thr Pro Ile Asp Tyr Ala Arg 
         195                200                205
Gln Ala Gly His His Glu Leu Ala Glu Arg Leu Val Glu Cys Gln Tyr 
     210                215                220
Glu Leu Thr Asp Arg Leu Ala Phe Tyr Leu Cys Gly Arg Lys Pro Asp 
 225                230                235                240
His Lys Asn Gly His Tyr Ile Ile Pro Gln Met Ala Asp Arg Ser Arg 
                 245                250                255
Gln Lys Cys Met Ser Gln Ser Leu Asp Leu Ser Glu Leu Ala Lys Ala 
             260                265                270
Ala Lys Lys Lys Leu Gln Ala Leu Ser Asn Arg Leu Phe Glu Glu Leu 
         275                280                285
Ala Met Asp Val Tyr Asp Glu Val Asp Arg Arg Glu Asn Asp Ala Val 
     290                295                300
Trp Leu Ala Thr Gln Asn His Ser Thr Leu Val Thr Glu Arg Ser Ala 
 305                310                315                320
Val Pro Phe Leu Pro Val Asn Pro Glu Tyr Ser Ala Thr Arg Asn Gln 
                 325                330                335
Gly Arg Gln Lys Leu Ala Arg Phe Asn Ala Arg Glu Phe Ala Thr Leu 
             340                345                350
Ile Ile Asp Ile Leu Ser Glu Ala Lys Arg Arg Gln Gln Gly Lys Ser 
         355                360                365
Leu Ser Ser Pro Thr Asp Asn Leu Glu Leu Ser Ala Arg Asn Gln Ser 
     370                375                380
Asp Leu Asp Asp Gln His Asp Tyr Asp Ser Val Ala Ser Asp Glu Asp 
 385                390                395                400
Thr Asp Gln Glu Pro Leu Pro Ser Ala Gly Ala Thr Arg Asn Asn Arg 
                 405                410                415
Ala Arg Ser Met Asp Ser Ser Asp Leu Ser Asp Gly Ala Val Thr Leu 
             420                425                430
Gln Glu Tyr Leu Glu Leu Lys Lys Ala Leu Ala Thr Ser Glu Ala Lys 
         435                440                445
Val Gln Gln Leu Met Lys Val Asn Ser Ser Leu Ser Asp Glu Leu Arg 
     450                455                460
Lys Leu Gln Arg Glu Ile His Lys Leu Gln Ala Glu Asn Leu Gln Leu 
 465                470                475                480
Arg Gln Pro Pro Gly Pro Val Pro Val Pro Ser Leu Pro Ser Glu Arg 
                 485                490                495
Ala Glu His Thr Leu Met Gly Pro Gly Gly Ser Thr His Arg Arg Asp 
             500                505                510
Arg Gln Ala Phe Ser Met Tyr Glu Pro Gly Ser Ala Leu Lys Pro Phe 
         515                520                525
Gly Gly Ala Pro Gly Asp Glu Leu Ala Thr Arg Leu Gln Pro Phe His 
     530                535                540
Ser Thr Glu Leu Glu Asp Asp Ala Ile Tyr Ser Val His Val Pro Ala 
 545                550                555                560
Gly Leu Tyr Arg Ile Arg Lys Gly Val Ser Ala Ser Ser Val Thr Phe 
                 565                570                575
Thr Pro Ser Ser Pro Leu Leu Ser Ser Ser Gln Glu Gly Ser Arg His 
             580                585                590
Ala Ser Lys Leu Ser Arg His Gly Ser Gly Ala Glu Ser Asp Tyr Glu 
         595                600                605
Asn Thr Gln Ser Gly Glu Pro Leu Leu Gly Leu Glu Gly Lys Arg Phe 
     610                615                620
Leu Glu Leu Ser Lys Glu Asp Glu Leu His Ala Glu Leu Glu Ser Leu 
 625                630                635                640
Asp Gly Asp Pro Asp Pro Gly Leu Pro Ser Thr Glu Asp Val Ile Leu 
                 645                650                655
Lys Thr Glu Gln Val Thr Lys Asn Ile Gln Glu Leu Leu Arg Ala Ala 
             660                665                670
Gln Glu Phe Lys His Asp Ser Phe Val Pro Cys Ser Glu Lys Ile His 
         675                680                685
Leu Ala Val Thr Glu Met Ala Ser Leu Phe Pro Lys Arg Pro Ala Leu 
     690                695                700
Glu Pro Val Arg Ser Ser Leu Arg Leu Leu Asn Ala Ser Ala Tyr Arg 
 705                710                715                720
Leu Gln Ser Glu Cys Arg Lys Thr Val Pro Pro Glu Pro Gly Ala Pro 
                 725                730                735
Val Asp Phe Gln Leu Leu Thr Gln Gln Val Ile Gln Cys Ala Tyr Asp 
             740                745                750
Ile Ala Lys Ala Ala Lys Gln Leu Val Thr Ile Thr Thr Arg Glu Lys 
         755                760                765
Lys Gln 
     770



<210> 1178
<211> 497
<212> DNA
<213> Homo sapiens
<308> BG984848
<400> 1178

aagactctc  aggatcccc  ccgagatgg  ctccctctt  ccaaaggta  aggtttcaa  60
gagaggacc  ggagtggga  ggcctcgag  tgggtcagg  gtggagaat  ccatctgat  120
gctacctgg  tggagacac  gacaaactg  gccctgatc  cagctggcg  cttaaagtc  180
aaggtccag  ctcactcct  ccccctcca  aggccagcc  tggagccag  gcggagctc  240
ctgcggctg  tcaacgcca  cgcctaccg  ctgcagagt  agtgccgga  gacagtgcc  300
ccagagccc  gcgccccag  ggacttcca  ctgccgact  agcaggtga  ccagtgcgc  360
tatgacatc  ccaaggctg  caagcagct  gtcaccatc  ccacccgag  gaagaagca  420
tgacctctc  ccccacacc  tcacctgca  cctaggacc  cactggcca  aggagctgg  480
ccactccag  ctctggg  497



<210> 1179
<211> 761
<212> PRT
<213> Homo sapiens
<308> NP_054749
<400> 1179

Met Ser Arg Lys Gly Pro Arg Ala Glu Val Cys Ala Asp Cys Ser Ala 
  1               5                  10                  15
Pro Asp Pro Gly Trp Ala Ser Ile Ser Arg Gly Val Leu Val Cys Asp 
             20                  25                  30
Glu Cys Cys Ser Val His Arg Ser Leu Gly Arg His Ile Ser Ile Val 
         35                  40                  45
Lys His Leu Arg His Ser Ala Trp Pro Pro Thr Leu Leu Gln Met Val 
     50                  55                  60
His Thr Leu Ala Ser Asn Gly Ala Asn Ser Ile Trp Glu His Ser Leu 
 65                  70                  75                  80
Leu Asp Pro Ala Gln Val Gln Ser Gly Arg Arg Lys Ala Asn Pro Gln 
                 85                  90                  95
Asp Lys Val His Pro Ile Lys Ser Glu Phe Ile Arg Ala Lys Tyr Gln 
             100                105                110
Met Leu Ala Phe Val His Lys Leu Ser Cys Arg Asp Asp Asp Gly Val 
         115                120                125
Thr Ala Lys Asp Leu Ser Lys Gln Leu His Ser Ser Val Arg Thr Gly 
     130                135                140
Asn Leu Glu Thr Cys Leu Arg Leu Leu Ser Leu Gly Ala Gln Ala Asn 
 145                150                155                160
Phe Phe His Pro Glu Lys Gly Thr Thr Pro Leu His Val Ala Ala Lys 
                 165                170                175
Ala Gly Gln Thr Leu Gln Ala Glu Leu Leu Val Val Tyr Gly Ala Asp 
             180                185                190
Pro Gly Ser Pro Asp Val Asn Gly Arg Thr Pro Ile Asp Tyr Ala Arg 
         195                200                205
Gln Ala Gly His His Glu Leu Ala Glu Arg Leu Val Glu Cys Gln Tyr 
     210                215                220
Glu Leu Thr Asp Arg Leu Ala Phe Tyr Leu Cys Gly Arg Lys Pro Asp 
 225                230                235                240
His Lys Asn Gly His Tyr Ile Ile Pro Gln Met Ala Asp Ser Leu Asp 
                 245                250                255
Leu Ser Glu Leu Ala Lys Ala Ala Lys Lys Lys Leu Gln Ala Leu Ser 
             260                265                270
Asn Arg Leu Phe Glu Glu Leu Ala Met Asp Val Tyr Asp Glu Val Asp 
         275                280                285
Arg Arg Glu Asn Asp Ala Val Trp Leu Ala Thr Gln Asn His Ser Thr 
     290                295                300
Leu Val Thr Glu Arg Ser Ala Val Pro Phe Leu Pro Val Asn Pro Glu 
 305                310                315                320
Tyr Ser Ala Thr Arg Asn Gln Gly Arg Gln Lys Leu Ala Arg Phe Asn 
                 325                330                335
Ala Arg Glu Phe Ala Thr Leu Ile Ile Asp Ile Leu Ser Glu Ala Lys 
             340                345                350
Arg Arg Gln Gln Gly Lys Ser Leu Ser Ser Pro Thr Asp Asn Leu Glu 
         355                360                365
Leu Ser Leu Arg Ser Gln Ser Asp Leu Asp Asp Gln His Asp Tyr Asp 
     370                375                380
Ser Val Ala Ser Asp Glu Asp Thr Asp Gln Glu Pro Leu Arg Ser Thr 
 385                390                395                400
Gly Ala Thr Arg Ser Asn Arg Ala Arg Ser Met Asp Ser Ser Asp Leu 
                 405                410                415
Ser Asp Gly Ala Val Thr Leu Gln Glu Tyr Leu Glu Leu Lys Lys Ala 
             420                425                430
Leu Ala Thr Ser Glu Ala Lys Val Gln Gln Leu Met Lys Val Asn Ser 
         435                440                445
Ser Leu Ser Asp Glu Leu Arg Arg Leu Gln Arg Glu Ile His Lys Leu 
     450                455                460
Gln Ala Glu Asn Leu Gln Leu Arg Gln Pro Pro Gly Pro Val Pro Thr 
 465                470                475                480
Pro Pro Leu Pro Ser Glu Arg Ala Glu His Thr Pro Met Ala Pro Gly 
                 485                490                495
Gly Ser Thr His Arg Arg Asp Arg Gln Ala Phe Ser Met Tyr Glu Pro 
             500                505                510
Gly Ser Ala Leu Lys Pro Phe Gly Gly Pro Pro Gly Asp Glu Leu Thr 
         515                520                525
Thr Arg Leu Gln Pro Phe His Ser Thr Glu Leu Glu Asp Asp Ala Ile 
     530                535                540
Tyr Ser Val His Val Pro Ala Gly Leu Tyr Arg Ile Arg Lys Gly Val 
 545                550                555                560
Ser Ala Ser Ala Val Pro Phe Thr Pro Ser Ser Pro Leu Leu Ser Cys 
                 565                570                575
Ser Gln Glu Gly Ser Arg His Thr Ser Lys Leu Ser Arg His Gly Ser 
             580                585                590
Gly Ala Asp Ser Asp Tyr Glu Asn Thr Gln Ser Gly Asp Pro Leu Leu 
         595                600                605
Gly Leu Glu Gly Lys Arg Phe Leu Glu Leu Gly Lys Glu Glu Asp Phe 
     610                615                620
His Pro Glu Leu Glu Ser Leu Asp Gly Asp Leu Asp Pro Gly Leu Pro 
 625                630                635                640
Ser Thr Glu Asp Val Ile Leu Lys Thr Glu Gln Val Thr Lys Asn Ile 
                 645                650                655
Gln Glu Leu Leu Arg Ala Ala Gln Glu Phe Lys His Asp Ser Phe Val 
             660                665                670
Pro Cys Ser Glu Lys Ile His Leu Ala Val Thr Glu Met Ala Ser Leu 
         675                680                685
Phe Pro Lys Arg Pro Ala Leu Glu Pro Val Arg Ser Ser Leu Arg Leu 
     690                695                700
Leu Asn Ala Ser Ala Tyr Arg Leu Gln Ser Glu Cys Arg Lys Thr Val 
 705                710                715                720
Pro Pro Glu Pro Gly Ala Pro Val Asp Phe Gln Leu Leu Thr Gln Gln 
                 725                730                735
Val Ile Gln Cys Ala Tyr Asp Ile Ala Lys Ala Ala Lys Gln Leu Val 
             740                745                750
Thr Ile Thr Thr Arg Glu Lys Lys Gln 
         755                760



<210> 1180
<211> 2335
<212> DNA
<213> Rattus norvegicus
<308> AF086624
<400> 1180

gtccccaag  tccaccagc  cttggtgaa  cgacaggga  cgtccggct  tcccagcac  60
actttgcca  actcaaaac  gccacaccg  aaagtgagc  tcgggcgga  ggaggcgga  120
ctacaggcg  ccccgcctc  gcggaggga  acgtgtctc  gcggtccaa  accccgggg  180
gaggcggcc  gggcgtgtg  gccgctcgg  cagctgccg  ctacgggct  ccgcgcggc  240
accgggcaa  tgcgccgcg  ggctgcccc  ctgagcgct  ggcctcggg  ccgtgggat  300
cgccgcgct  tctgcggtc  ggaagaccg  cctcccgcg  ccgtgccgg  cgggtcaga  360
gcggcgccg  acgcgaggc  acccgcgat  ctgctgtcc  agttcggct  cctggcgca  420
ctctgcggg  ctggcggcg  ggaccacct  ccagtgaag  tcctacagc  agccaaggc  480
gacaaggag  gcttcgaga  ggtgtacca  gtgggcgcc  tgctcggca  cggcggctt  540
ggcacggtc  acgcgggca  ccgcatcgc  gacggactc  cggtggctg  gaagcacgt  600
gtgaaggag  gggtgaccg  gtggggcag  ctcggcgga  tggccgtgc  cctggaggt  660
gtgctgctg  gcaaggtgg  cgcggcggg  ggcgcgcgc  gcgtcatcc  cctgctgga  720
tggttcgag  ggcccgacg  cttcctgct  gtgctggag  gacccgagc  ggcacagga  780
ctcttcgac  tcatcactg  acgcggcgc  ctggacgag  ctctggctc  tcgcttctt  840
gcgcaggtg  tcgccgctg  gcggcactg  cacaattgt  gggtcgtgc  ccgcgacat  900
aaggacgag  acctgctgg  ggacttgcg  tcgggcgag  tgaagctca  cgacttcgg  960
tcgggcgcg  tgctcaagg  cacggtcta  actgacttt  atggcaccc  tgtgtacag  1020
cccccagag  ggatccggt  tcatcgata  cacgggcgg  ctgccactg  gtggtctct  1080
ggtgtactg  tctacgaca  ggtgtgtgg  gacattccc  ttgagcagg  tgaggagat  1140
ttgcgcggc  ggctctttt  ccggaggag  gtctcccca  agtgccagc  gcttattga  1200
tggtgtctc  ccctgcggc  ctcagagag  ccctcgctg  accaaattg  tgcccatcc  1260
tggatgctg  ggacagagg  cagcgttcc  gagaactgt  accttcggc  ctgtgccct  1320
gatactgat  acggagcca  taccacttc  agcagtgag  gcttgtgag  aggaggagg  1380
gcctggact  cacactggg  gcctgggct  agcctagcc  gccctctcc  agaatgaac  1440
ttttctgcc  gggatgtct  ctgcaaaag  agtgacctc  gacccctgg  gacctttgc  1500
ctcggcacc  ggcctgttt  ctttgcttt  agtgccttt  tgaacgctg  tccacaggg  1560
ctgggtttt  ttgagctct  ctgtccaaa  atggctgcg  gctaagcaa  gtcccgcct  1620
ccctgggtg  atacttgaa  ccgagaccc  accctgctg  tccatcttg  ggcagcctt  1680
ctgaccaag  gtgtttgac  tggagcgcc  tgtggtgcc  acctccaac  ctccagtct  1740
ctggtcttc  tctgggcat  tctgcacaa  caatgcaac  ctgggccac  gctgcccgc  1800
tgcctccct  gcaccgcac  caacgagcg  gccacggtc  cttatttat  gtgtgatca  1860
cctggaggg  gcccctgcc  tgctggggc  atttattgt  taatttatt  gctgaggtt  1920
cttcctcca  gcaaccacc  tctccaggc  cctggggtg  tcaggaaag  caagggtgg  1980
cgttcagtc  acagacggc  tcctggttc  tgcacctgc  gtaggtccc  aaccccatg  2040
ttgtgggag  aggaatttg  acagtggct  atttaaggg  agtgggaga  cctgtcacc  2100
tgggcactc  gcgctgggg  gggggttta  attattgac  ttgtacagt  tgcttgctg  2160
ctctgaaag  tggggtggg  gacagagtc  caagccctt  atttatttt  gcaactgtg  2220
tctgtgacc  tggtgtgag  aggcatcag  ggtggggtt  tataagttc  aaagtgtga  2280
atgtctgga  atcatattt  ttatacagg  atttcaatt  aatgttttg  tatat  2335



<210> 1181
<211> 455
<212> PRT
<213> Rattus norvegicus
<308> AAC68900
<400> 1181

Met Pro Lys Leu His Gln Pro Leu Val Asn Arg Gln Gly Ala Ser Gly 
  1               5                  10                  15
Phe Pro Ser Thr Thr Leu Pro Asp Ser Lys Gln Pro His Arg Lys Val 
             20                  25                  30
Ser Leu Gly Arg Lys Glu Ala Glu Leu Gln Ala Ala Pro Pro Pro Arg 
         35                  40                  45
Arg Asp Thr Cys Leu Arg Gly Pro Lys Pro Arg Gly Glu Ala Ala Gly 
     50                  55                  60
Ala Cys Glu Pro Leu Gly Gln Leu Pro Ser Thr Gly Phe Arg Ala Ala 
 65                  70                  75                  80
Thr Gly Gln Leu Arg Arg Ala Ala Ala Pro Leu Ser Ala Arg Pro Arg 
                 85                  90                  95
Gly Arg Gly Ile Arg Arg Ala Val Cys Gly Gln Glu Asp Arg Pro Pro 
             100                105                110
Ala Ser Val Pro Asp Gly Ser Glu Ala Ala Pro His Ala Arg Pro Pro 
         115                120                125
Ala Met Leu Leu Ser Lys Phe Gly Ser Leu Ala His Leu Cys Gly Pro 
     130                135                140
Gly Gly Val Asp His Leu Pro Val Lys Ile Leu Gln Pro Ala Lys Ala 
 145                150                155                160
Asp Lys Glu Ser Phe Glu Lys Val Tyr Gln Val Gly Ala Val Leu Gly 
                 165                170                175
Ser Gly Gly Phe Gly Thr Val Tyr Ala Gly Ser Arg Ile Ala Asp Gly 
             180                185                190
Leu Pro Val Ala Val Lys His Val Val Lys Glu Arg Val Thr Glu Trp 
         195                200                205
Gly Ser Leu Gly Gly Met Ala Val Pro Leu Glu Val Val Leu Leu Arg 
     210                215                220
Lys Val Gly Ala Ala Gly Gly Ala Arg Gly Val Ile Arg Leu Leu Asp 
 225                230                235                240
Trp Phe Glu Arg Pro Asp Gly Phe Leu Leu Val Leu Glu Arg Pro Glu 
                 245                250                255
Pro Ala Gln Asp Leu Phe Asp Phe Ile Thr Glu Arg Gly Ala Leu Asp 
             260                265                270
Glu Pro Leu Ala Arg Arg Phe Phe Ala Gln Val Leu Ala Ala Val Arg 
         275                280                285
His Cys His Asn Cys Gly Val Val His Arg Asp Ile Lys Asp Glu Asn 
     290                295                300
Leu Leu Val Asp Leu Arg Ser Gly Glu Leu Lys Leu Ile Asp Phe Gly 
 305                310                315                320
Ser Gly Ala Val Leu Lys Asp Thr Val Tyr Thr Asp Phe Asp Gly Thr 
                 325                330                335
Arg Val Tyr Ser Pro Pro Glu Trp Ile Arg Tyr His Arg Tyr His Gly 
             340                345                350
Arg Ser Ala Thr Val Trp Ser Leu Gly Val Leu Leu Tyr Asp Met Val 
         355                360                365
Cys Gly Asp Ile Pro Phe Glu Gln Asp Glu Glu Ile Leu Arg Gly Arg 
     370                375                380
Leu Phe Phe Arg Arg Arg Val Ser Pro Glu Cys Gln Gln Leu Ile Glu 
 385                390                395                400
Trp Cys Leu Ser Leu Arg Pro Ser Glu Arg Pro Ser Leu Asp Gln Ile 
                 405                410                415
Ala Ala His Pro Trp Met Leu Gly Thr Glu Gly Ser Val Pro Glu Asn 
             420                425                430
Cys Asp Leu Arg Leu Cys Ala Leu Asp Thr Asp Asp Gly Ala Ser Thr 
         435                440                445
Thr Ser Ser Ser Glu Ser Leu 
     450                455



<210> 1182
<211> 811
<212> DNA
<213> Homo sapiens
<308> AL526992
<400> 1182

ggaccgacg  gacacgccg  gcgcctccg  ggctgcgct  cgaaaacga  tcccggagc  60
gccccgcgc  cgccgcacc  ggccctcgc  cgcccgaag  caggcgcca  gctgccccg  120
cgtctcccc  gctagcgcc  ggccgccgc  gcctcgcgg  ccccgggcg  aagggggcg  180
ggtcccgat  cgccccgcc  ccgcggagg  atacgcggc  ccgcggccc  aaacccccg  240
gcgaggcgg  cggggcggg  gaggcgctc  gcctgctgc  cgtctacgc  gtccccgcg  300
gccttccgg  cccactgcg  cgcgcggac  gcctcgggc  cggacggcc  gtgtccccg  360
cgcgccgct  gcccggatc  gccgcggct  cggcgcctg  ggctcgggg  tccggggag  420
ccgtcgccc  cgatgctgc  ctccaagtt  ggctccctg  cgcacctct  cgggcccgg  480
ggcgtggac  acctcccgg  gaagatcct  cagccagcc  aggcggaca  ggagagctt  540
gagaaggcg  accaggtgg  cgccgtgct  ggtagcggc  gcttcggca  ggtctacgc  600
ggtagccgc  tcgccgacg  gctcccggt  gctgtgaag  acgtggtga  ggagcgggt  660
accgagtgg  gcagcctgg  cggcgcgac  gtgcccctg  aggtggtgc  gctgcgcaa  720
gtgggcgcg  cgggcggcg  gcgcggcgt  atccgcctg  tggactggt  cgagcggcc  780
gacggcttc  tgctggtgc  ggagcggcc  a  811



<210> 1183
<211> 313
<212> PRT
<213> Homo sapiens
<308> AAA60089
<400> 1183

Met Leu Leu Ser Lys Ile Asn Ser Leu Ala His Leu Arg Ala Ala Pro 
  1               5                  10                  15
Cys Asn Asp Leu His Ala Thr Lys Leu Ala Pro Gly Lys Glu Lys Glu 
             20                  25                  30
Pro Leu Glu Ser Gln Tyr Gln Val Gly Pro Leu Leu Gly Ser Gly Gly 
         35                  40                  45
Phe Gly Ser Val Tyr Ser Gly Ile Arg Val Ser Asp Asn Leu Pro Val 
     50                  55                  60
Ala Ile Lys His Val Glu Lys Asp Arg Ile Ser Asp Trp Gly Glu Leu 
 65                  70                  75                  80
Pro Asn Gly Thr Arg Val Pro Met Glu Val Val Leu Leu Lys Lys Val 
                 85                  90                  95
Ser Ser Gly Phe Ser Gly Val Ile Arg Leu Leu Asp Trp Phe Glu Arg 
             100                105                110
Pro Asp Ser Phe Val Leu Ile Leu Glu Arg Pro Glu Pro Val Gln Asp 
         115                120                125
Leu Phe Asp Phe Ile Thr Glu Arg Gly Ala Leu Gln Glu Glu Leu Ala 
     130                135                140
Arg Ser Phe Phe Trp Gln Val Leu Glu Ala Val Arg His Cys His Asn 
 145                150                155                160
Cys Gly Val Leu His Arg Asp Ile Lys Asp Glu Asn Ile Leu Ile Asp 
                 165                170                175
Leu Asn Arg Gly Glu Leu Lys Leu Ile Asp Phe Gly Ser Gly Ala Leu 
             180                185                190
Leu Lys Asp Thr Val Tyr Thr Asp Phe Asp Gly Thr Arg Val Tyr Ser 
         195                200                205
Pro Pro Glu Trp Ile Arg Tyr His Arg Tyr His Gly Arg Ser Ala Ala 
     210                215                220
Val Trp Ser Leu Gly Ile Leu Leu Tyr Asp Met Val Cys Gly Asp Ile 
 225                230                235                240
Pro Phe Glu His Asp Glu Glu Ile Ile Arg Gly Gln Val Phe Phe Arg 
                 245                250                255
Gln Arg Val Ser Ser Glu Cys Gln His Leu Ile Arg Trp Cys Leu Ala 
             260                265                270
Leu Arg Pro Ser Asp Arg Pro Thr Phe Glu Glu Ile Gln Asn His Pro 
         275                280                285
Trp Met Gln Asp Val Leu Leu Pro Gln Glu Thr Ala Glu Ile His Leu 
     290                295                300
His Ser Leu Ser Pro Gly Pro Ser Lys 
 305                310



<210> 1184
<211> 1234
<212> DNA
<213> Rattus norvegicus
<308> AF086758
<400> 1184

gttctttct  ccctcactc  tgtagctcc  acccccaat  ctacagacc  agtccagac  60
accgcaagc  tcagccaca  tgtcacaaa  ttgacacac  ctgtcacaa  cgctaccaa  120
aagcccatg  cctctactc  catgaccgc  ggccctaca  ccagtgcca  aggtccagt  180
cagactacc  ctagcccca  ccacaccaa  acctactac  tgcgcacct  cggccacaa  240
accatggac  cggtgccca  gatcgacca  taccggcac  cggccgcgc  gctgggcga  300
aagctgctc  ggcccagcc  ggcagagct  cacgatgag  tggaaaagg  accttttga  360
gatggcttt  cgaatggag  agaaagtac  ccaaccaga  atgctgtgg  cacatacac  420
gccgaaagt  aaggagttg  aaagtttgg  tggatcaag  gtgtattag  acgatgtat  480
ttgaacatt  ggggtgtga  gctctttat  cgattgtca  ggattgtgg  tcaagctgg  540
ataggtctc  ccgttcttg  aataccaat  gccactgtt  tgacatccc  tcccggatt  600
tctacttca  caatatcta  caatgggat  ctgacagga  gaggaactt  ctctttaat  660
tccaagtct  gggcccaaa  ttggcggtg  aattggctt  atcttccct  tgcccaatg  720
aggggcagg  ggaaagaaa  tggtgggat  cacagagac  gtaaggtgg  gctgcttaa  780
gaacattcc  aacttatga  agatgaatt  aatgacatc  gaattattg  agccataac  840
gtggtggtt  ttgtgggca  ctcagtggc  ggaatggag  gggaaacaa  ggctcagat  900
gtcattctg  tgattcttc  tctggccat  gctgacttc  tcataggga  atttatctc  960
ctggacagc  agaagccca  gggtttctt  ggctataaa  ctgaaatat  tagtgagaa  1020
tttggaccg  attttcgag  agaagagac  ttcttttct  tattcgcca  cttttttcc  1080
gctgcaact  gtattctag  tggggcgaa  atctcgggt  accttgcag  tcctcagtc  1140
gccataccc  aaggaacgc  cttagccat  ttgattacg  cagtggttt  cataggaat  1200
gcagtgtct  taggttcgt  tgctgttcg  gatg  1234



<210> 1185
<211> 369
<212> PRT
<213> Rattus norvegicus
<308> AAD09008
<400> 1185

Met Ala Ser Thr Leu Met Thr Ala Gly Pro Thr Ala Ser Ala Thr Gly 
  1               5                  10                  15
Pro Val Gln Thr Thr Thr Ser Pro Thr His Thr Asn Thr Tyr Tyr Leu 
             20                  25                  30
Arg Thr Phe Gly His Asn Thr Met Asp Ala Val Pro Arg Ile Asp His 
         35                  40                  45
Tyr Arg His Thr Ala Ala Gln Leu Gly Glu Lys Leu Leu Arg Pro Ser 
     50                  55                  60
Leu Ala Glu Leu His Asp Glu Leu Glu Lys Glu Pro Phe Glu Asp Gly 
 65                  70                  75                  80
Phe Ala Asn Gly Glu Glu Ser Thr Pro Thr Arg Asp Ala Val Val Thr 
                 85                  90                  95
Tyr Thr Ala Glu Ser Lys Gly Val Val Lys Phe Gly Trp Ile Lys Gly 
             100                105                110
Val Leu Val Arg Cys Met Leu Asn Ile Trp Gly Val Met Leu Phe Ile 
         115                120                125
Arg Leu Ser Trp Ile Val Gly Gln Ala Gly Ile Gly Leu Ser Val Leu 
     130                135                140
Val Ile Pro Met Ala Thr Val Val Thr Ser Leu Pro Gly Leu Ser Thr 
 145                150                155                160
Ser Pro Ile Ser Thr Asn Gly Ile Leu Thr Gly Gly Gly Thr Phe Ser 
                 165                170                175
Leu Ile Ser Lys Ser Gly Ala Gln Ile Trp Arg Cys Asn Trp Leu Asp 
             180                185                190
Leu Pro Phe Ala Gln Cys Arg Gly Arg Trp Lys Glu Ser Gly Gly Ile 
         195                200                205
His Arg Asp Gly Lys Val Glu Leu Leu Lys Glu His Ser Lys Leu Met 
     210                215                220
Ile Asp Glu Phe Asn Asp Ile Arg Ile Ile Gly Ala Ile Thr Val Val 
 225                230                235                240
Val Phe Val Gly Ile Ser Val Ala Gly Met Glu Trp Glu Thr Lys Ala 
                 245                250                255
Gln Met Val Ile Leu Val Ile Leu Leu Leu Ala Ile Ala Asp Phe Val 
             260                265                270
Ile Gly Thr Phe Ile Ser Leu Asp Ser Lys Lys Pro Lys Gly Phe Phe 
         275                280                285
Gly Tyr Lys Ser Glu Ile Phe Ser Glu Asn Phe Gly Pro Asp Phe Arg 
     290                295                300
Glu Glu Glu Thr Phe Phe Ser Val Phe Ala Ile Phe Phe Pro Ala Ala 
 305                310                315                320
Thr Gly Ile Leu Ala Gly Ala Asn Ile Ser Gly Asp Leu Ala Asp Pro 
                 325                330                335
Gln Ser Ala Ile Pro Lys Gly Thr Leu Leu Ala Ile Leu Ile Thr Thr 
             340                345                350
Val Val Tyr Ile Gly Ile Ala Val Ser Val Gly Ser Cys Ala Val Arg 
         355                360                365
Asp 
     370



<210> 1186
<211> 4098
<212> DNA
<213> Homo sapiens
<308> NM_001046
<400> 1186

ggtggcctc  gtggccgtc  aggctagcg  cggcccgca  gcggcgggg  gaaagactc  60
ctcacctgg  cttgcggct  tggccaccg  cggccaggg  tgtggaggg  gtgctgccg  120
agacgtccg  cgggctctg  agttccgcc  ggggtcggg  agctatgga  ccgcggccc  180
cggcgccct  ctccggcgc  ccgggactg  ccggggtcg  ggagacgcc  tcagccgct  240
cgctggccg  agccagggt  gaactgccc  gcacggctg  gccctcggt  ccggaggat  300
ctgcgcccg  gagccggga  ggcggcggg  tccgcgatg  gggccccgc  gcggccggg  360
acgggctgg  cagaccctt  gggcccacc  cgagccaga  ccgtttcca  gtggacctg  420
tttccgaga  cgccgggcg  gccgctgct  cggcggcgg  ggcggcggc  gcagcggcg  480
cggctggtg  tggggcggg  gccaagcag  cccccgcgg  cggggaagc  agcggcgag  540
gcgagccag  taaaggcag  gaggaagcc  agggccgct  ccgcgtgaa  ttcgtggac  600
cagctgcct  ctcgtcggc  gaagacagc  tgtcagatg  tgccggggt  ggagtcgac  660
ggcccaacg  gagcttcca  aacggcggg  acacggtgc  gagcgaggg  agcagcctg  720
actccggcg  cggcggcgg  agtgggcac  accagcact  ctattatga  acccacacc  780
acacctact  cctgcgcac  ttcggccac  acaccatgg  cgctgtgcc  aggatcgat  840
actaccggc  cacagccgc  cagctgggc  agaagctgc  ccggcctag  ctggcggag  900
tccacgacg  gctggaaaa  gaacctttt  aggatggct  tgcaaatgg  gaagaaagt  960
ctccaacca  agatgctgt  gtcacgtat  ctgcagaaa  taaaggagt  gtgaagttt  1020
gctggatca  gggtgtatt  gtacgttgt  tgttaaaca  ttggggtgt  atgcttttc  1080
ttagattgt  atggattgt  ggtcaagct  gaataggtc  atcagtcct  gtaataatg  1140
tggccactg  tgtgacaac  atcacagga  tgtctactt  agcaatagc  actaatgga  1200
ttgtaagag  aggaggagc  tattattta  tatctagaa  tctagggcc  gaatttggt  1260
gtgcaattg  tctaatctt  gcctttgcc  acgctgttg  agttgctat  tatgtggtt  1320
gatttgcag  aaccgtggt  gagttgctt  aggaacatt  catacttat  atagatgaa  1380
tcaatgata  ccgaattat  ggagccatt  cagtcgtga  tcttttagg  atctcagta  1440
ctggaatgg  gtgggaagc  aaagctcag  ttgttcttt  ggtgatcct  cttcttgct  1500
ttggtgatt  cgtcatagg  acatttatc  cactggaga  caagaagcc  aaagggttt  1560
ttggttata  atctgaaat  tttaatgag  actttgggc  cgattttcg  gaggaagag  1620
ctttctttt  tgtatttgc  atctttttt  ctgctgcaa  tggtattct  gctggagca  1680
atatctcag  tgatcttgc  gatcctcag  cagccatac  caaaggaac  ctcctagcc  1740
ttttaatta  tacattggt  tacgtagga  ttgcagtat  tgtaggttc  tgtgttgtt  1800
gagatgcca  tggaaacgt  aatgacact  tcgtaacag  gctaacaaa  tgtacttct  1860
cagcctgca  attaaactt  gatttttca  cttgtgaaa  cagtccttg  tcctatggc  1920
taatgaaca  cttccaggt  atgagtatg  tgtcaggat  tacaccact  atttctgca  1980
gtatatttt  agccactct  tcttcagca  tagcatccc  agtgagtgc  cccaaaata  2040
ttcaggctc  atgtaagga  aacatctac  cagctttcc  gatgtttgc  aaaggttat  2100
ggaaaaata  tgaacctct  cgtggctac  tcttaacat  cttaattgc  cttggattc  2160
tcttaattg  tgaactgaa  gttattgca  caattatct  aaacttctt  cttgcatca  2220
atgcattga  caatttttc  gtattccat  catcacttg  aaaatctcc  ggatggcgt  2280
ctgcattca  atactacaa  atgtggata  cacttcttg  agcaattct  tgttgcata  2340
taatgttcg  cattaactg  tgggctgca  tgctaacat  tgtgatagt  cttgggctg  2400
atatttatg  tacctacaa  aaaccagat  tgaattggg  atcctctac  caagccctg  2460
cttacctga  tgcactgca  cattcaatt  gtctttctg  agtggaaga  cacgtgaaa  2520
actttaggc  acagtgtct  gttatgaca  gtgctccaa  ctcacgtcc  gctttactt  2580
atcttgttc  tgatttcac  aaaaatgtt  gtttgatga  ctgtggcca  gtacatatg  2640
gtcctcgaa  acaagccat  aaagagatg  ccatcgatc  agccaaata  cagcgatgg  2700
ttattaaga  caaaatgaa  gcattttat  ctccagtac  tgcagatga  ttgagagaa  2760
gtgcacagt  tttgatgca  gctgctggt  ttggtcgta  gaagccaaa  acacttgtc  2820
ttggattta  gaaagattg  ttgcaagca  atatgaggg  tgtggatat  tatataaac  2880
tatttcatg  tgcttttga  atacaatat  gagtagtgg  tattcgcct  aaagaaggt  2940
tggatatat  tcatcttca  ggacaagaa  aattattgt  atcacaaga  aaatctcct  3000
gcaccaagg  tgtggtagt  agtgtggaa  atagtaaaa  gtccgattt  gatacttcc  3060
aaccactca  tgaaaaacc  attacacac  aagttgagg  agaggatgg  aagactgca  3120
ctcaaccac  gttgaaaaa  gaatccaaa  gccctattg  gcctttaaa  gtagctgac  3180
aaaagcttc  tgaagctag  acacagttt  agaaaaaac  aggaaagaa  actattgat  3240
tctggtggc  ttttgatga  ggaggtttg  ccttattga  accttacct  ctgacgacc  3300
agaaaaaat  gaaagactg  aagatcaga  tattcattg  tggaaagat  aacagaata  3360
accatgacc  gagagcgat  gctactttg  ttagcaagt  ccggataga  ttttctgat  3420
tcatggttc  aggagatat  aataccaaa  caaagaaag  aaatattat  gcttttgag  3480
aaatcattg  gccatacag  cttcatgaa  atgataaag  gcaagatat  gcagataaa  3540
tgaaagaag  tgaaccatg  cgaataaca  ataatgagc  tgaacttta  aagaccaag  3600
cataccggc  gatcaggtt  aatgagtta  taaaggaac  ttcaagcac  gctaatatt  3660
ttgtcatga  tctcccagt  gcacgaaaa  gtgctgtgt  tagtgctct  tacatggca  3720
ggttagaag  tctatctaa  gacctacca  caatcctcc  agttcgtgg  aatcatcag  3780
gtgtcctta  cttctattc  taaatgttc  atacagtgg  cagccctcc  gaatggtac  3840
tcagtgcct  gtgtagtaa  ctgaaatct  caatgacac  ttaacatca  aatggcgaa  3900
ggtgacttt  ctttcacga  ttcattaat  tgaaagcac  caggaaagc  tgctccatt  3960
ataacgtgt  tggagactt  ggttttagt  aattccata  ctcaatctt  atggtgatt  4020
ttctctgtt  aactgaagt  tgtgagagt  gttttcctt  gctacttga  tagcaataa  4080
agcgtgtta  ctttttgg  4098



<210> 1187
<211> 1212
<212> PRT
<213> Homo sapiens
<308> P55011
<400> 1187

Met Glu Pro Arg Pro Thr Ala Pro Ser Ser Gly Ala Pro Gly Leu Ala 
  1               5                  10                  15
Gly Val Gly Glu Thr Pro Ser Ala Ala Ala Leu Ala Ala Ala Arg Val 
             20                  25                  30
Glu Leu Pro Gly Thr Ala Val Pro Ser Val Pro Glu Asp Ala Ala Pro 
         35                  40                  45
Ala Ser Arg Asp Gly Gly Gly Val Arg Asp Glu Gly Pro Ala Ala Ala 
     50                  55                  60
Gly Asp Gly Leu Gly Arg Pro Leu Gly Pro Thr Pro Ser Gln Ser Arg 
 65                  70                  75                  80
Phe Gln Val Asp Leu Val Ser Glu Asn Ala Gly Arg Ala Ala Ala Ala 
                 85                  90                  95
Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Ala Gly Ala Gly 
             100                105                110
Ala Lys Gln Thr Pro Ala Asp Gly Glu Ala Ser Gly Glu Ser Glu Pro 
         115                120                125
Ala Lys Gly Ser Glu Glu Ala Lys Gly Arg Phe Arg Val Asn Phe Val 
     130                135                140
Asp Pro Ala Ala Ser Ser Ser Ala Glu Asp Ser Leu Ser Asp Ala Ala 
 145                150                155                160
Gly Val Gly Val Asp Gly Pro Asn Val Ser Phe Gln Asn Gly Gly Asp 
                 165                170                175
Thr Val Leu Ser Glu Gly Ser Ser Leu His Ser Gly Gly Gly Gly Gly 
             180                185                190
Ser Gly His His Gln His Tyr Tyr Tyr Asp Thr His Thr Asn Thr Tyr 
         195                200                205
Tyr Leu Arg Thr Phe Gly His Asn Thr Met Asp Ala Val Pro Arg Ile 
     210                215                220
Asp His Tyr Arg His Thr Ala Ala Gln Leu Gly Glu Lys Leu Leu Arg 
 225                230                235                240
Pro Ser Leu Ala Glu Leu His Asp Glu Leu Glu Lys Glu Pro Phe Glu 
                 245                250                255
Asp Gly Phe Ala Asn Gly Glu Glu Ser Thr Pro Thr Arg Asp Ala Val 
             260                265                270
Val Thr Tyr Thr Ala Glu Ser Lys Gly Val Val Lys Phe Gly Trp Ile 
         275                280                285
Lys Gly Val Leu Val Arg Cys Met Leu Asn Ile Trp Gly Val Met Leu 
     290                295                300
Phe Ile Arg Leu Ser Trp Ile Val Gly Gln Ala Gly Ile Gly Leu Ser 
 305                310                315                320
Val Leu Val Ile Met Met Ala Thr Val Val Thr Thr Ile Thr Gly Leu 
                 325                330                335
Ser Thr Ser Ala Ile Ala Thr Asn Gly Phe Val Arg Gly Gly Gly Ala 
             340                345                350
Tyr Tyr Leu Ile Ser Arg Ser Leu Gly Pro Glu Phe Gly Gly Ala Ile 
         355                360                365
Gly Leu Ile Phe Ala Phe Ala Asn Ala Val Ala Val Ala Met Tyr Val 
     370                375                380
Val Gly Phe Ala Glu Thr Val Val Glu Leu Leu Lys Glu His Ser Ile 
 385                390                395                400
Leu Met Ile Asp Glu Ile Asn Asp Ile Arg Ile Ile Gly Ala Ile Thr 
                 405                410                415
Val Val Ile Leu Leu Gly Ile Ser Val Ala Gly Met Glu Trp Glu Ala 
             420                425                430
Lys Ala Gln Ile Val Leu Leu Val Ile Leu Leu Leu Ala Ile Gly Asp 
         435                440                445
Phe Val Ile Gly Thr Phe Ile Pro Leu Glu Ser Lys Lys Pro Lys Gly 
     450                455                460
Phe Phe Gly Tyr Lys Ser Glu Ile Phe Asn Glu Asn Phe Gly Pro Asp 
 465                470                475                480
Phe Arg Glu Glu Glu Thr Phe Phe Ser Val Phe Ala Ile Phe Phe Pro 
                 485                490                495
Ala Ala Thr Gly Ile Leu Ala Gly Ala Asn Ile Ser Gly Asp Leu Ala 
             500                505                510
Asp Pro Gln Ser Ala Ile Pro Lys Gly Thr Leu Leu Ala Ile Leu Ile 
         515                520                525
Thr Thr Leu Val Tyr Val Gly Ile Ala Val Ser Val Gly Ser Cys Val 
     530                535                540
Val Arg Asp Ala Thr Gly Asn Val Asn Asp Thr Ile Val Thr Glu Leu 
 545                550                555                560
Thr Asn Cys Thr Ser Ala Ala Cys Lys Leu Asn Phe Asp Phe Ser Ser 
                 565                570                575
Cys Glu Ser Ser Pro Cys Ser Tyr Gly Leu Met Asn Asn Phe Gln Val 
             580                585                590
Met Ser Met Val Ser Gly Phe Thr Pro Leu Ile Ser Ala Gly Ile Phe 
         595                600                605
Ser Ala Thr Leu Ser Ser Ala Leu Ala Ser Leu Val Ser Ala Pro Lys 
     610                615                620
Ile Phe Gln Ala Leu Cys Lys Asp Asn Ile Tyr Pro Ala Phe Gln Met 
 625                630                635                640
Phe Ala Lys Gly Tyr Gly Lys Asn Asn Glu Pro Leu Arg Gly Tyr Ile 
                 645                650                655
Leu Thr Phe Leu Ile Ala Leu Gly Phe Ile Leu Ile Ala Glu Leu Asn 
             660                665                670
Val Ile Ala Pro Ile Ile Ser Asn Phe Phe Leu Ala Ser Tyr Ala Leu 
         675                680                685
Ile Asn Phe Ser Val Phe His Ala Ser Leu Ala Lys Ser Pro Gly Trp 
     690                695                700
Arg Pro Ala Phe Lys Tyr Tyr Asn Met Trp Ile Ser Leu Leu Gly Ala 
 705                710                715                720
Ile Leu Cys Cys Ile Val Met Phe Val Ile Asn Trp Trp Ala Ala Leu 
                 725                730                735
Leu Thr Tyr Val Ile Val Leu Gly Leu Tyr Ile Tyr Val Thr Tyr Lys 
             740                745                750
Lys Pro Asp Val Asn Trp Gly Ser Ser Thr Gln Ala Leu Thr Tyr Leu 
         755                760                765
Asn Ala Leu Gln His Ser Ile Arg Leu Ser Gly Val Glu Asp His Val 
     770                775                780
Lys Asn Phe Arg Pro Gln Cys Leu Val Met Thr Gly Ala Pro Asn Ser 
 785                790                795                800
Arg Pro Ala Leu Leu His Leu Val His Asp Phe Thr Lys Asn Val Gly 
                 805                810                815
Leu Met Ile Cys Gly His Val His Met Gly Pro Arg Arg Gln Ala Met 
             820                825                830
Lys Glu Met Ser Ile Asp Gln Ala Lys Tyr Gln Arg Trp Leu Ile Lys 
         835                840                845
Asn Lys Met Lys Ala Phe Tyr Ala Pro Val His Ala Asp Asp Leu Arg 
     850                855                860
Glu Gly Ala Gln Tyr Leu Met Gln Ala Ala Gly Leu Gly Arg Met Lys 
 865                870                875                880
Pro Asn Thr Leu Val Leu Gly Phe Lys Lys Asp Trp Leu Gln Ala Asp 
                 885                890                895
Met Arg Asp Val Asp Met Tyr Ile Asn Leu Phe His Asp Ala Phe Asp 
             900                905                910
Ile Gln Tyr Gly Val Val Val Ile Arg Leu Lys Glu Gly Leu Asp Ile 
         915                920                925
Ser His Leu Gln Gly Gln Glu Glu Leu Leu Ser Ser Gln Glu Lys Ser 
     930                935                940
Pro Gly Thr Lys Asp Val Val Val Ser Val Glu Tyr Ser Lys Lys Ser 
 945                950                955                960
Asp Leu Asp Thr Ser Lys Pro Leu Ser Glu Lys Pro Ile Thr His Lys 
                 965                970                975
Val Glu Glu Glu Asp Gly Lys Thr Ala Thr Gln Pro Leu Leu Lys Lys 
             980                985                990
Glu Ser Lys Gly Pro Ile Val Pro Leu Asn Val Ala Asp Gln Lys Leu 
         995                1000                1005
Leu Glu Ala Ser Thr Gln Phe Gln Lys Lys Gln Gly Lys Asn Thr Ile 
     1010                1015                1020
Asp Val Trp Trp Leu Phe Asp Asp Gly Gly Leu Thr Leu Leu Ile Pro 
 1025                1030                1035                1040
Tyr Leu Leu Thr Thr Lys Lys Lys Trp Lys Asp Cys Lys Ile Arg Val 
                 1045                1050                1055
Phe Ile Gly Gly Lys Ile Asn Arg Ile Asp His Asp Arg Arg Ala Met 
             1060                1065                1070
Ala Thr Leu Leu Ser Lys Phe Arg Ile Asp Phe Ser Asp Ile Met Val 
         1075                1080                1085
Leu Gly Asp Ile Asn Thr Lys Pro Lys Lys Glu Asn Ile Ile Ala Phe 
     1090                1095                1100
Glu Glu Ile Ile Glu Pro Tyr Arg Leu His Glu Asp Asp Lys Glu Gln 
 1105                1110                1115                1120
Asp Ile Ala Asp Lys Met Lys Glu Asp Glu Pro Trp Arg Ile Thr Asp 
                 1125                1130                1135
Asn Glu Leu Glu Leu Tyr Lys Thr Lys Thr Tyr Arg Gln Ile Arg Leu 
             1140                1145                1150
Asn Glu Leu Leu Lys Glu His Ser Ser Thr Ala Asn Ile Ile Val Met 
         1155                1160                1165
Ser Leu Pro Val Ala Arg Lys Gly Ala Val Ser Ser Ala Leu Tyr Met 
     1170                1175                1180
Ala Trp Leu Glu Ala Leu Ser Lys Asp Leu Pro Pro Ile Leu Leu Val 
 1185                1190                1195                1200
Arg Gly Asn His Gln Ser Val Leu Thr Phe Tyr Ser 
                 1205                1210



<210> 1188
<211> 2703
<212> DNA
<213> Rattus norvegicus
<308> AF087431
<400> 1188

cgcccgcat  gcccggggc  agaggcgac  gcgcgctgc  gccgcagag  gggcgcgcc  60
gctggagag  gcgcggggt  cgggccggc  ggatggcag  gccggcggg  cgcgcggct  120
ggcgggcgg  gcggccctg  ccgtggtgg  tttggcgct  gccttcggc  tgtcggggc  180
ctgggtgct  gcgtggctg  gtgtgcgcc  cgcgctcac  ctgcacccc  ctccgtcag  240
gctaccgcc  gactcctcc  gtcctgccg  ggccccgga  tttttttgg  gtacctatc  300
cccacacgt  tatttcggc  tgaagactc  cagccccaa  ccactgctc  cgggactga  360
gtgggcgca  caaggcgcc  ccccgggga  ccctcctaa  ctcaggcac  catgcgaac  420
aggagacgg  gtgggtccc  atggctggg  gttccatga  ggactctcc  ttggtcggc  480
acatatcta  gatggggcc  taaggctca  cactgagtt  gtcaagaga  ctgggggtc  540
tcacggagg  gattggagc  ggagagtta  cgtagagcc  caggcctca  gtacacctt  600
cttcccttt  gtctccctg  tcttctacg  ggtaacaga  gggcaagag  tcctactac  660
agaggttgg  gccaaagga  agttgaagt  catcagtgg  cacaccagt  aacttggtg  720
cttccgcct  acacttctg  caccaacca  tccaggaga  actgtccct  agcatggca  780
ctacaatgt  ttctggtcc  ccaacccag  gctgcctct  ctcacagac  tggtaaaga  840
ccacctaaa  agctggttt  atcaccggc  cccaggagc  tctccggaa  gataccttg  900
cttgcctgg  tctcttaag  gggaagaga  aggccctag  gggcaaggg  agttcttgg  960
ccagcaggt  acactgaaa  cccctttct  tgtggagtt  gtgtttgaa  ctggcagtg  1020
caggacagg  agagaccaa  cctctgagc  gctggtagg  ggccaactg  cccgggccc  1080
ggagagcca  gctgcagca  tcaaggagc  ttttgagag  accttccag  taaaggaga  1140
gggcctgag  cctgaggag  aggctctgg  tcaggttgc  ctcagtggc  tacttggtg  1200
gattggtta  ttctatgga  agggtttgg  gttgccaga  actggcatg  aagggtctg  1260
acagaaaat  gacccttcc  tatttccgc  tgtccccct  ttctctggg  tcccttccc  1320
gtcattctt  ccacgaggc  tcctctggg  tgaaggctt  caccagcta  tggtccagc  1380
atgggatcc  cacctcacc  gggaggccc  aggacactg  ctggggctg  tcaatgctg  1440
cggttggat  gggcgagag  agattctgg  ggatgaggc  agagcccga  tgcccccgg  1500
attcctagt  caacgtgca  cccatgcca  ccctccaac  ctgctcctg  cagtcatac  1560
catgctaga  ggccgggcc  ctgaggact  ggccttcct  cgcagggct  tcccccgct  1620
gcatgcctg  ttctcttgg  tccatcaaa  tcaggcagg  ccagtgcca  tttcctacc  1680
ctggcgggg  agggatcta  ctttgccta  cctacttaa  cccaagaca  tgccctcgg  1740
cctggatga  taccccagg  cctcacatc  ttctgcagc  gagcggcac  tggacctgc  1800
gtgctgggt  acattgggt  cccgggtgc  gtcacagct  gcagaagag  ttggggaga  1860
tgaagctgc  gcagagttg  gcccattgg  tgcctctct  gaagcagct  gaagtctcg  1920
tgagctgca  tgggctcct  agctgggtg  ctttgccga  tttgggaac  acacaaaag  1980
agtacagct  aagtctagg  ccccacagg  gctggttag  gtggtaggc  ggcctccag  2040
tcgactgca  tatgtggat  ccctgggct  tgtctctct  tttcctttg  tgctacaac  2100
gctggagcc  agctcaccc  gcttgggac  cctgctgga  gttctagct  atagccgcc  2160
tctctggag  ccctttggg  tgcgctccc  ttcagcctc  agtctcttt  ataaacagc  2220
aaatacgga  cacgatcca  cttactggc  aggtgcggt  tggctgaat  tcaactacc  2280
ggctttggg  gcactacac  actatgggc  tgtggaggg  cctcacaag  ttcaggctg  2340
caaactcta  cgtgaactt  gggccaatg  agtaagcaa  gtacggcag  aataccagg  2400
tacagggtt  ctgtgggaa  agtacagtg  ccaggatgg  cggggcatg  gctgccgcc  2460
cttccaagg  tggaccagt  ttgttttac  gatcatggc  gaagagtac  agtgggaca  2520
aaggaaagc  aggcctttg  gtcacttgg  atatgcaga  aagggcttg  gtttctggt  2580
tcagtgttt  agatcccgt  agctcatct  aggtgtctc  ttattgtca  cccatacag  2640
tctggggtg  acgtgaact  aaagagtct  tttttctaa  taaactgga  aacaacgga  2700
ttc  2703



<210> 1189
<211> 834
<212> PRT
<213> Rattus norvegicus
<308> AAC36477
<400> 1189

Met Ala Arg Gly Glu Arg Arg Arg Arg Ala Ala Ala Ala Glu Gly Ala 
  1               5                  10                  15
Arg Pro Leu Glu Arg Ala Arg Gly Ala Gly Arg Arg Asp Gly Arg Ala 
             20                  25                  30
Gly Gly Ala Arg Gly Ser Ala Gly Gly Ala Ala Leu Ala Val Val Val 
         35                  40                  45
Leu Ala Leu Ala Phe Gly Leu Ser Gly Arg Trp Val Leu Ala Trp Leu 
     50                  55                  60
Gly Val Arg Arg Ala Leu Thr Leu His Pro Ala Pro Ser Ala Leu Pro 
 65                  70                  75                  80
Pro Asp Ser Ser Ser Pro Ala Val Ala Pro Glu Phe Phe Trp Gly Thr 
                 85                  90                  95
Tyr Arg Pro His Val Tyr Phe Gly Met Lys Thr Arg Ser Pro Lys Pro 
             100                105                110
Leu Leu Thr Gly Leu Met Trp Ala Gln Gln Gly Ala Thr Pro Gly Thr 
         115                120                125
Pro Pro Lys Leu Arg His Thr Cys Glu Gln Gly Asp Gly Val Gly Pro 
     130                135                140
Tyr Gly Trp Glu Phe His Asp Gly Leu Ser Phe Gly Arg Gln His Ile 
 145                150                155                160
Tyr Asp Gly Ala Leu Arg Leu Thr Thr Glu Phe Val Lys Arg Ser Gly 
                 165                170                175
Gly His His Gly Gly Asp Trp Ser Trp Arg Val Thr Val Glu Pro Gln 
             180                185                190
Ala Ser Gly Thr Pro Ser Phe Pro Leu Val Ser Leu Phe Phe Tyr Val 
         195                200                205
Val Thr Asp Gly Gln Glu Val Leu Leu Pro Glu Val Gly Ala Lys Gly 
     210                215                220
Gln Leu Lys Phe Ile Ser Gly His Thr Ser Glu Leu Gly Asp Phe Arg 
 225                230                235                240
Leu Thr Leu Leu Pro Pro Thr Thr Pro Gly Asp Thr Val Pro Lys His 
                 245                250                255
Gly Ser Tyr Asn Val Phe Trp Ser Ser Asn Pro Gly Leu Pro Leu Leu 
             260                265                270
Thr Asp Met Val Lys Ser His Leu Asn Ser Trp Phe His His Arg Pro 
         275                280                285
Pro Gly Ala Ser Pro Glu Arg Tyr Leu Gly Leu Pro Gly Ser Leu Lys 
     290                295                300
Trp Glu Glu Arg Gly Pro Ser Gly Gln Gly Gln Phe Leu Val Gln Gln 
 305                310                315                320
Val Thr Leu Lys Ala Pro Phe Ser Val Glu Phe Val Phe Glu Ser Gly 
                 325                330                335
Ser Ala Arg Thr Gly Arg Asp Gln Ala Ser Glu Gln Leu Val Gly Gly 
             340                345                350
Gln Leu Thr Arg Ala Leu Glu Ser His Ala Ala Ala Phe Lys Glu Arg 
         355                360                365
Phe Glu Arg Thr Phe Gln Leu Lys Glu Lys Gly Leu Ser Pro Glu Glu 
     370                375                380
Gln Ala Leu Gly Gln Val Ala Leu Ser Gly Leu Leu Gly Gly Ile Gly 
 385                390                395                400
Tyr Phe Tyr Gly Gln Gly Leu Val Leu Pro Asp Thr Gly Met Glu Gly 
                 405                410                415
Ser Glu Gln Lys Met Asp Pro Ser Leu Phe Pro Pro Val Pro Leu Phe 
             420                425                430
Ser Gly Val Pro Ser Arg Ser Phe Phe Pro Arg Gly Phe Leu Trp Asp 
         435                440                445
Glu Gly Phe His Gln Leu Val Val Gln Arg Trp Asp Pro His Leu Thr 
     450                455                460
Arg Glu Ala Leu Gly His Trp Leu Gly Leu Leu Asn Ala Asp Gly Trp 
 465                470                475                480
Ile Gly Arg Glu Gln Ile Leu Gly Asp Glu Ala Arg Ala Arg Val Pro 
                 485                490                495
Pro Glu Phe Leu Val Gln Arg Ala Ala His Ala Asn Pro Pro Thr Leu 
             500                505                510
Leu Leu Pro Val Ile His Met Leu Glu Gly Arg Ala Pro Glu Asp Leu 
         515                520                525
Ala Phe Leu Arg Arg Ala Phe Pro Arg Leu His Ala Trp Phe Ser Trp 
     530                535                540
Leu His Gln Ser Gln Ala Gly Pro Val Pro Leu Ser Tyr Arg Trp Arg 
 545                550                555                560
Gly Arg Asp Leu Ala Leu Pro Thr Leu Leu Asn Pro Lys Thr Leu Pro 
                 565                570                575
Ser Gly Leu Asp Asp Tyr Pro Arg Ala Ser His Pro Ser Ala Ala Glu 
             580                585                590
Arg His Leu Asp Leu Arg Cys Trp Val Thr Leu Gly Ala Arg Val Leu 
         595                600                605
Ser Gln Leu Ala Glu Glu Leu Gly Glu Thr Glu Ala Ala Ala Glu Leu 
     610                615                620
Gly Pro Leu Ala Ala Ser Leu Glu Ala Ala Gly Ser Leu Asp Glu Leu 
 625                630                635                640
His Trp Ala Pro Glu Leu Gly Val Phe Ala Asp Phe Gly Asn His Thr 
                 645                650                655
Lys Ala Val Gln Leu Lys Ser Arg Pro Pro Gln Gly Leu Val Arg Val 
             660                665                670
Val Gly Arg Pro Pro Ala Arg Leu Gln Tyr Val Asp Ala Leu Gly Tyr 
         675                680                685
Val Ser Leu Phe Pro Leu Leu Leu Gln Leu Leu Glu Pro Ser Ser Pro 
     690                695                700
Arg Leu Gly Pro Leu Leu Asp Val Leu Ala Asp Ser Arg His Leu Trp 
 705                710                715                720
Ser Pro Phe Gly Leu Arg Ser Leu Ser Ala Ser Ser Leu Phe Tyr Lys 
                 725                730                735
Gln Arg Asn Thr Glu His Asp Pro Pro Tyr Trp Arg Gly Ala Val Trp 
             740                745                750
Leu Asn Ile Asn Tyr Leu Ala Leu Gly Ala Leu His His Tyr Gly Arg 
         755                760                765
Val Glu Gly Pro His Lys Val Gln Ala Ala Lys Leu Tyr Arg Glu Leu 
     770                775                780
Arg Ala Asn Val Val Ser Asn Val Arg Gln Gln Tyr Gln Ala Thr Gly 
 785                790                795                800
Phe Leu Trp Glu Gln Tyr Ser Asp Gln Asp Gly Arg Gly Met Gly Cys 
                 805                810                815
Arg Pro Phe Gln Gly Trp Thr Ser Leu Val Leu Leu Ile Met Ala Glu 
             820                825                830
Glu Tyr 
         835



<210> 1190
<211> 2866
<212> DNA
<213> Homo sapiens
<308> XM_035229
<400> 1190

ggaggcgga  gcgcaggcg  tggctggca  gtgtcgcta  ccggacggt  gtcgccagg  60
cgagaggcg  gagccggag  ggtgaggca  gacccgggc  ccactgccg  ctctccgag  120
tcttgtgac  cggacctca  tgccaggat  gctcggggc  agcggcggc  ccgcgcagt  180
ccggcagag  gagtgcgga  agccgagag  gcggctcgg  gaggccccg  gcgacggga  240
ggccggggc  gcgggccgc  tagcacggc  ggaggagtg  ctctggccg  cgtggtcct  300
tctttggcc  tgggtatgt  ggggcgctg  gtgctggcg  ggtaccgtg  gcggcgggc  360
gtcacgctg  actccgcgc  tcctgtgtt  cctgccgac  cctccagcc  cgccgtggc  420
ccggacctc  tctggggaa  ctaccgccc  cacgtctac  tcggcatga  gacccgcag  480
ccgaagccc  tcctcaccg  actgatgtg  gcgcagcag  gcaccaccc  ggggactcc  540
aagctcagg  acacgtgtg  gcaggggga  ggtgtgggt  cctatggct  ggagttcca  600
gacggcctc  ccttcgggc  ccaacacat  caggatggg  ccttaaggc  caccactga  660
ttcgtcaag  ggcctgggg  tcagcacgg  ggggactgg  gctggagag  gactgtaga  720
cctcaggac  caggtactt  tgccctccc  ttggtctcc  tgttcttct  tgtggtgac  780
gatggcaag  aagtcctac  accagaggt  ggggccaag  ggcagttga  gtttatcag  840
gggcacacc  gtgaacttg  tgacttccg  tttacactt  tgccaccaa  cagtccagg  900
gatacagcc  ccaagtatg  cagctacaa  gtcttctgg  cctccaacc  aggactgcc  960
ctgctgaca  agatggtaa  gagtcgcct  aatagctgg  ttcagcatc  gcccccagg  1020
gccccccct  aacgctacc  cggcttgcc  ggatccctg  agtgggagg  cagaggtcc  1080
agtgggcaa  ggcaggggc  gttcttgat  cagcaggtg  ccctgaaaa  tcccatttc  1140
atagagttt  tgtttgaat  aggcagtgc  caggcagga  gaaatcaag  cctgccaag  1200
ctggcaggc  gtctactga  ccaggccct  gagagccat  ctgaaggct  tagagagcg  1260
tttgagaag  ccttccagc  gaaggagaa  ggcctgagc  ctggcgagc  ggttttggg  1320
caggctgcc  tcagcggcc  ccttggtgg  attggctac  tctacggac  agggctggt  1380
ttgccagac  tcggggtgg  agggtctga  cagaaggtg  acccagccc  ctttccacc  1440
gtacctctt  ttacagcag  gccctcccg  tcattcttc  cacgaggct  cctttggga  1500
gaaggcttt  accagctgg  ggttcagcg  tgggatccc  ccctcaccc  ggaagccct  1560
ggccactgg  tggggctgc  aaatgctga  ggctggatt  ggagggagc  gatactggg  1620
gatgaggcc  gagcccggg  gcctccaga  ttcctagta  aacgagcag  ccacgccaa  1680
cccccaacc  tacttttgc  tgtagccca  atgctagag  ttggtgacc  tgacgactt  1740
gctttcctc  gaaaggcct  gccccgcct  catgcctgg  tttcctggc  ccatcagag  1800
caggcaggc  cactgccac  atcttaccg  tggcgggga  gggaccctg  cttaccaac  1860
ttactgaac  ccaagaccc  accctctgg  ctggatgac  acccccggg  ttcacaccc  1920
tcagtaacc  agcggcacc  ggacctgcg  tgttgggtg  cactgggtg  ccgtgtgct  1980
acgcggctg  cagagcatc  gggtgaggc  gaggtagct  ctgagctgg  cccactggc  2040
gcctcactg  aggcagcag  gagcctgga  gagctgcac  gggccccag  gctaggagt  2100
tttgcagac  ttgggaacc  cacaaaagc  gtacagctg  agcccaggc  ccctcaggg  2160
ctcgttcgg  tggtgggtc  gccccaacc  caactgcag  atgtagatg  tcttggcta  2220
gtcagtctt  ttcccttgc  gctgcgact  ctggacccc  cctcatccc  ccttgggcc  2280
ctgctggac  ttctagccg  cagccgcca  ctctggagc  cctttggtt  acgctccct  2340
gcagcctcc  gctcctttt  tggccagcg  aattcagag  atgatcccc  ctactggcg  2400
ggtgctgtg  ggctcaatg  caactacct  gctttggga  cactccacc  ctatgggca  2460
ctggagggt  ctcaccagg  tcgggctgc  aaactccac  gtgagctcc  tgccaacgt  2520
gtaggcaat  tatggcgcc  gtaccaggc  acaggcttt  tttgggagc  gtacagtga  2580
cgcgatggg  gaggcatgg  ctgccgccc  ttccacggc  ggaccagcc  tgtcttact  2640
gccatggct  aagactact  aagggaggg  gaggagggg  gccaagaca  tcatgccac  2700
ctggctctg  agggacaaa  gcttctggc  tttgccccc  gccccttgg  taccagtaa  2760
tcaaacctt  ctcatttca  ctcaggtgt  tccttgctg  catcccaca  agccctggg  2820
tgaatgtga  tccagagtc  atttttcta  ataaattgg  aaaaac  2866



<210> 1191
<211> 837
<212> PRT
<213> Homo sapiens
<308> XP_035229
<400> 1191

Met Ala Arg Gly Glu Arg Arg Arg Arg Ala Val Pro Ala Glu Gly Val 
  1               5                  10                  15
Arg Thr Ala Glu Arg Ala Ala Arg Gly Gly Pro Gly Arg Arg Asp Gly 
             20                  25                  30
Arg Gly Gly Gly Pro Arg Ser Thr Ala Gly Gly Val Ala Leu Ala Val 
         35                  40                  45
Val Val Leu Ser Leu Ala Leu Gly Met Ser Gly Arg Trp Val Leu Ala 
     50                  55                  60
Trp Tyr Arg Ala Arg Arg Ala Val Thr Leu His Ser Ala Pro Pro Val 
 65                  70                  75                  80
Leu Pro Ala Asp Ser Ser Ser Pro Ala Val Ala Pro Asp Leu Phe Trp 
                 85                  90                  95
Gly Thr Tyr Arg Pro His Val Tyr Phe Gly Met Lys Thr Arg Ser Pro 
             100                105                110
Lys Pro Leu Leu Thr Gly Leu Met Trp Ala Gln Gln Gly Thr Thr Pro 
         115                120                125
Gly Thr Pro Lys Leu Arg His Thr Cys Glu Gln Gly Asp Gly Val Gly 
     130                135                140
Pro Tyr Gly Trp Glu Phe His Asp Gly Leu Ser Phe Gly Arg Gln His 
 145                150                155                160
Ile Gln Asp Gly Ala Leu Arg Leu Thr Thr Glu Phe Val Lys Arg Pro 
                 165                170                175
Gly Gly Gln His Gly Gly Asp Trp Ser Trp Arg Val Thr Val Glu Pro 
             180                185                190
Gln Asp Ser Gly Thr Ser Ala Leu Pro Leu Val Ser Leu Phe Phe Tyr 
         195                200                205
Val Val Thr Asp Gly Lys Glu Val Leu Leu Pro Glu Val Gly Ala Lys 
     210                215                220
Gly Gln Leu Lys Phe Ile Ser Gly His Thr Ser Glu Leu Gly Asp Phe 
 225                230                235                240
Arg Phe Thr Leu Leu Pro Pro Thr Ser Pro Gly Asp Thr Ala Pro Lys 
                 245                250                255
Tyr Gly Ser Tyr Asn Val Phe Trp Thr Ser Asn Pro Gly Leu Pro Leu 
             260                265                270
Leu Thr Glu Met Val Lys Ser Arg Leu Asn Ser Trp Phe Gln His Arg 
         275                280                285
Pro Pro Gly Ala Pro Pro Glu Arg Tyr Leu Gly Leu Pro Gly Ser Leu 
     290                295                300
Lys Trp Glu Asp Arg Gly Pro Ser Gly Gln Gly Gln Gly Gln Phe Leu 
 305                310                315                320
Ile Gln Gln Val Thr Leu Lys Ile Pro Ile Ser Ile Glu Phe Val Phe 
                 325                330                335
Glu Ser Gly Ser Ala Gln Ala Gly Gly Asn Gln Ala Leu Pro Arg Leu 
             340                345                350
Ala Gly Ser Leu Leu Thr Gln Ala Leu Glu Ser His Ala Glu Gly Phe 
         355                360                365
Arg Glu Arg Phe Glu Lys Thr Phe Gln Leu Lys Glu Lys Gly Leu Ser 
     370                375                380
Ser Gly Glu Gln Val Leu Gly Gln Ala Ala Leu Ser Gly Leu Leu Gly 
 385                390                395                400
Gly Ile Gly Tyr Phe Tyr Gly Gln Gly Leu Val Leu Pro Asp Ile Gly 
                 405                410                415
Val Glu Gly Ser Glu Gln Lys Val Asp Pro Ala Leu Phe Pro Pro Val 
             420                425                430
Pro Leu Phe Thr Ala Val Pro Ser Arg Ser Phe Phe Pro Arg Gly Phe 
         435                440                445
Leu Trp Asp Glu Gly Phe His Gln Leu Val Val Gln Arg Trp Asp Pro 
     450                455                460
Ser Leu Thr Arg Glu Ala Leu Gly His Trp Leu Gly Leu Leu Asn Ala 
 465                470                475                480
Asp Gly Trp Ile Gly Arg Glu Gln Ile Leu Gly Asp Glu Ala Arg Ala 
                 485                490                495
Arg Val Pro Pro Glu Phe Leu Val Gln Arg Ala Val His Ala Asn Pro 
             500                505                510
Pro Thr Leu Leu Leu Pro Val Ala His Met Leu Glu Val Gly Asp Pro 
         515                520                525
Asp Asp Leu Ala Phe Leu Arg Lys Ala Leu Pro Arg Leu His Ala Trp 
     530                535                540
Phe Ser Trp Leu His Gln Ser Gln Ala Gly Pro Leu Pro Leu Ser Tyr 
 545                550                555                560
Arg Trp Arg Gly Arg Asp Pro Ala Leu Pro Thr Leu Leu Asn Pro Lys 
                 565                570                575
Thr Leu Pro Ser Gly Leu Asp Asp Tyr Pro Arg Ala Ser His Pro Ser 
             580                585                590
Val Thr Glu Arg His Leu Asp Leu Arg Cys Trp Val Ala Leu Gly Ala 
         595                600                605
Arg Val Leu Thr Arg Leu Ala Glu His Leu Gly Glu Ala Glu Val Ala 
     610                615                620
Ala Glu Leu Gly Pro Leu Ala Ala Ser Leu Glu Ala Ala Glu Ser Leu 
 625                630                635                640
Asp Glu Leu His Trp Ala Pro Glu Leu Gly Val Phe Ala Asp Phe Gly 
                 645                650                655
Asn His Thr Lys Ala Val Gln Leu Lys Pro Arg Pro Pro Gln Gly Leu 
             660                665                670
Val Arg Val Val Gly Arg Pro Gln Pro Gln Leu Gln Tyr Val Asp Ala 
         675                680                685
Leu Gly Tyr Val Ser Leu Phe Pro Leu Leu Leu Arg Leu Leu Asp Pro 
     690                695                700
Thr Ser Ser Arg Leu Gly Pro Leu Leu Asp Ile Leu Ala Asp Ser Arg 
 705                710                715                720
His Leu Trp Ser Pro Phe Gly Leu Arg Ser Leu Ala Ala Ser Ser Ser 
                 725                730                735
Phe Tyr Gly Gln Arg Asn Ser Glu His Asp Pro Pro Tyr Trp Arg Gly 
             740                745                750
Ala Val Trp Leu Asn Val Asn Tyr Leu Ala Leu Gly Ala Leu His His 
         755                760                765
Tyr Gly His Leu Glu Gly Pro His Gln Ala Arg Ala Ala Lys Leu His 
     770                775                780
Gly Glu Leu Arg Ala Asn Val Val Gly Asn Val Trp Arg Gln Tyr Gln 
 785                790                795                800
Ala Thr Gly Phe Leu Trp Glu Gln Tyr Ser Asp Arg Asp Gly Arg Gly 
                 805                810                815
Met Gly Cys Arg Pro Phe His Gly Trp Thr Ser Leu Val Leu Leu Ala 
             820                825                830
Met Ala Glu Asp Tyr 
         835



<210> 1192
<211> 2703
<212> DNA
<213> Rattus norvegicus
<308> AF087431
<400> 1192

cgcccgcat  gcccggggc  agaggcgac  gcgcgctgc  gccgcagag  gggcgcgcc  60
gctggagag  gcgcggggt  cgggccggc  ggatggcag  gccggcggg  cgcgcggct  120
ggcgggcgg  gcggccctg  ccgtggtgg  tttggcgct  gccttcggc  tgtcggggc  180
ctgggtgct  gcgtggctg  gtgtgcgcc  cgcgctcac  ctgcacccc  ctccgtcag  240
gctaccgcc  gactcctcc  gtcctgccg  ggccccgga  tttttttgg  gtacctatc  300
cccacacgt  tatttcggc  tgaagactc  cagccccaa  ccactgctc  cgggactga  360
gtgggcgca  caaggcgcc  ccccgggga  ccctcctaa  ctcaggcac  catgcgaac  420
aggagacgg  gtgggtccc  atggctggg  gttccatga  ggactctcc  ttggtcggc  480
acatatcta  gatggggcc  taaggctca  cactgagtt  gtcaagaga  ctgggggtc  540
tcacggagg  gattggagc  ggagagtta  cgtagagcc  caggcctca  gtacacctt  600
cttcccttt  gtctccctg  tcttctacg  ggtaacaga  gggcaagag  tcctactac  660
agaggttgg  gccaaagga  agttgaagt  catcagtgg  cacaccagt  aacttggtg  720
cttccgcct  acacttctg  caccaacca  tccaggaga  actgtccct  agcatggca  780
ctacaatgt  ttctggtcc  ccaacccag  gctgcctct  ctcacagac  tggtaaaga  840
ccacctaaa  agctggttt  atcaccggc  cccaggagc  tctccggaa  gataccttg  900
cttgcctgg  tctcttaag  gggaagaga  aggccctag  gggcaaggg  agttcttgg  960
ccagcaggt  acactgaaa  cccctttct  tgtggagtt  gtgtttgaa  ctggcagtg  1020
caggacagg  agagaccaa  cctctgagc  gctggtagg  ggccaactg  cccgggccc  1080
ggagagcca  gctgcagca  tcaaggagc  ttttgagag  accttccag  taaaggaga  1140
gggcctgag  cctgaggag  aggctctgg  tcaggttgc  ctcagtggc  tacttggtg  1200
gattggtta  ttctatgga  agggtttgg  gttgccaga  actggcatg  aagggtctg  1260
acagaaaat  gacccttcc  tatttccgc  tgtccccct  ttctctggg  tcccttccc  1320
gtcattctt  ccacgaggc  tcctctggg  tgaaggctt  caccagcta  tggtccagc  1380
atgggatcc  cacctcacc  gggaggccc  aggacactg  ctggggctg  tcaatgctg  1440
cggttggat  gggcgagag  agattctgg  ggatgaggc  agagcccga  tgcccccgg  1500
attcctagt  caacgtgca  cccatgcca  ccctccaac  ctgctcctg  cagtcatac  1560
catgctaga  ggccgggcc  ctgaggact  ggccttcct  cgcagggct  tcccccgct  1620
gcatgcctg  ttctcttgg  tccatcaaa  tcaggcagg  ccagtgcca  tttcctacc  1680
ctggcgggg  agggatcta  ctttgccta  cctacttaa  cccaagaca  tgccctcgg  1740
cctggatga  taccccagg  cctcacatc  ttctgcagc  gagcggcac  tggacctgc  1800
gtgctgggt  acattgggt  cccgggtgc  gtcacagct  gcagaagag  ttggggaga  1860
tgaagctgc  gcagagttg  gcccattgg  tgcctctct  gaagcagct  gaagtctcg  1920
tgagctgca  tgggctcct  agctgggtg  ctttgccga  tttgggaac  acacaaaag  1980
agtacagct  aagtctagg  ccccacagg  gctggttag  gtggtaggc  ggcctccag  2040
tcgactgca  tatgtggat  ccctgggct  tgtctctct  tttcctttg  tgctacaac  2100
gctggagcc  agctcaccc  gcttgggac  cctgctgga  gttctagct  atagccgcc  2160
tctctggag  ccctttggg  tgcgctccc  ttcagcctc  agtctcttt  ataaacagc  2220
aaatacgga  cacgatcca  cttactggc  aggtgcggt  tggctgaat  tcaactacc  2280
ggctttggg  gcactacac  actatgggc  tgtggaggg  cctcacaag  ttcaggctg  2340
caaactcta  cgtgaactt  gggccaatg  agtaagcaa  gtacggcag  aataccagg  2400
tacagggtt  ctgtgggaa  agtacagtg  ccaggatgg  cggggcatg  gctgccgcc  2460
cttccaagg  tggaccagt  ttgttttac  gatcatggc  gaagagtac  agtgggaca  2520
aaggaaagc  aggcctttg  gtcacttgg  atatgcaga  aagggcttg  gtttctggt  2580
tcagtgttt  agatcccgt  agctcatct  aggtgtctc  ttattgtca  cccatacag  2640
tctggggtg  acgtgaact  aaagagtct  tttttctaa  taaactgga  aacaacgga  2700
ttc  2703



<210> 1193
<211> 834
<212> PRT
<213> Rattus norvegicus
<308> AAC36477
<400> 1193

Met Ala Arg Gly Glu Arg Arg Arg Arg Ala Ala Ala Ala Glu Gly Ala 
  1               5                  10                  15
Arg Pro Leu Glu Arg Ala Arg Gly Ala Gly Arg Arg Asp Gly Arg Ala 
             20                  25                  30
Gly Gly Ala Arg Gly Ser Ala Gly Gly Ala Ala Leu Ala Val Val Val 
         35                  40                  45
Leu Ala Leu Ala Phe Gly Leu Ser Gly Arg Trp Val Leu Ala Trp Leu 
     50                  55                  60
Gly Val Arg Arg Ala Leu Thr Leu His Pro Ala Pro Ser Ala Leu Pro 
 65                  70                  75                  80
Pro Asp Ser Ser Ser Pro Ala Val Ala Pro Glu Phe Phe Trp Gly Thr 
                 85                  90                  95
Tyr Arg Pro His Val Tyr Phe Gly Met Lys Thr Arg Ser Pro Lys Pro 
             100                105                110
Leu Leu Thr Gly Leu Met Trp Ala Gln Gln Gly Ala Thr Pro Gly Thr 
         115                120                125
Pro Pro Lys Leu Arg His Thr Cys Glu Gln Gly Asp Gly Val Gly Pro 
     130                135                140
Tyr Gly Trp Glu Phe His Asp Gly Leu Ser Phe Gly Arg Gln His Ile 
 145                150                155                160
Tyr Asp Gly Ala Leu Arg Leu Thr Thr Glu Phe Val Lys Arg Ser Gly 
                 165                170                175
Gly His His Gly Gly Asp Trp Ser Trp Arg Val Thr Val Glu Pro Gln 
             180                185                190
Ala Ser Gly Thr Pro Ser Phe Pro Leu Val Ser Leu Phe Phe Tyr Val 
         195                200                205
Val Thr Asp Gly Gln Glu Val Leu Leu Pro Glu Val Gly Ala Lys Gly 
     210                215                220
Gln Leu Lys Phe Ile Ser Gly His Thr Ser Glu Leu Gly Asp Phe Arg 
 225                230                235                240
Leu Thr Leu Leu Pro Pro Thr Thr Pro Gly Asp Thr Val Pro Lys His 
                 245                250                255
Gly Ser Tyr Asn Val Phe Trp Ser Ser Asn Pro Gly Leu Pro Leu Leu 
             260                265                270
Thr Asp Met Val Lys Ser His Leu Asn Ser Trp Phe His His Arg Pro 
         275                280                285
Pro Gly Ala Ser Pro Glu Arg Tyr Leu Gly Leu Pro Gly Ser Leu Lys 
     290                295                300
Trp Glu Glu Arg Gly Pro Ser Gly Gln Gly Gln Phe Leu Val Gln Gln 
 305                310                315                320
Val Thr Leu Lys Ala Pro Phe Ser Val Glu Phe Val Phe Glu Ser Gly 
                 325                330                335
Ser Ala Arg Thr Gly Arg Asp Gln Ala Ser Glu Gln Leu Val Gly Gly 
             340                345                350
Gln Leu Thr Arg Ala Leu Glu Ser His Ala Ala Ala Phe Lys Glu Arg 
         355                360                365
Phe Glu Arg Thr Phe Gln Leu Lys Glu Lys Gly Leu Ser Pro Glu Glu 
     370                375                380
Gln Ala Leu Gly Gln Val Ala Leu Ser Gly Leu Leu Gly Gly Ile Gly 
 385                390                395                400
Tyr Phe Tyr Gly Gln Gly Leu Val Leu Pro Asp Thr Gly Met Glu Gly 
                 405                410                415
Ser Glu Gln Lys Met Asp Pro Ser Leu Phe Pro Pro Val Pro Leu Phe 
             420                425                430
Ser Gly Val Pro Ser Arg Ser Phe Phe Pro Arg Gly Phe Leu Trp Asp 
         435                440                445
Glu Gly Phe His Gln Leu Val Val Gln Arg Trp Asp Pro His Leu Thr 
     450                455                460
Arg Glu Ala Leu Gly His Trp Leu Gly Leu Leu Asn Ala Asp Gly Trp 
 465                470                475                480
Ile Gly Arg Glu Gln Ile Leu Gly Asp Glu Ala Arg Ala Arg Val Pro 
                 485                490                495
Pro Glu Phe Leu Val Gln Arg Ala Ala His Ala Asn Pro Pro Thr Leu 
             500                505                510
Leu Leu Pro Val Ile His Met Leu Glu Gly Arg Ala Pro Glu Asp Leu 
         515                520                525
Ala Phe Leu Arg Arg Ala Phe Pro Arg Leu His Ala Trp Phe Ser Trp 
     530                535                540
Leu His Gln Ser Gln Ala Gly Pro Val Pro Leu Ser Tyr Arg Trp Arg 
 545                550                555                560
Gly Arg Asp Leu Ala Leu Pro Thr Leu Leu Asn Pro Lys Thr Leu Pro 
                 565                570                575
Ser Gly Leu Asp Asp Tyr Pro Arg Ala Ser His Pro Ser Ala Ala Glu 
             580                585                590
Arg His Leu Asp Leu Arg Cys Trp Val Thr Leu Gly Ala Arg Val Leu 
         595                600                605
Ser Gln Leu Ala Glu Glu Leu Gly Glu Thr Glu Ala Ala Ala Glu Leu 
     610                615                620
Gly Pro Leu Ala Ala Ser Leu Glu Ala Ala Gly Ser Leu Asp Glu Leu 
 625                630                635                640
His Trp Ala Pro Glu Leu Gly Val Phe Ala Asp Phe Gly Asn His Thr 
                 645                650                655
Lys Ala Val Gln Leu Lys Ser Arg Pro Pro Gln Gly Leu Val Arg Val 
             660                665                670
Val Gly Arg Pro Pro Ala Arg Leu Gln Tyr Val Asp Ala Leu Gly Tyr 
         675                680                685
Val Ser Leu Phe Pro Leu Leu Leu Gln Leu Leu Glu Pro Ser Ser Pro 
     690                695                700
Arg Leu Gly Pro Leu Leu Asp Val Leu Ala Asp Ser Arg His Leu Trp 
 705                710                715                720
Ser Pro Phe Gly Leu Arg Ser Leu Ser Ala Ser Ser Leu Phe Tyr Lys 
                 725                730                735
Gln Arg Asn Thr Glu His Asp Pro Pro Tyr Trp Arg Gly Ala Val Trp 
             740                745                750
Leu Asn Ile Asn Tyr Leu Ala Leu Gly Ala Leu His His Tyr Gly Arg 
         755                760                765
Val Glu Gly Pro His Lys Val Gln Ala Ala Lys Leu Tyr Arg Glu Leu 
     770                775                780
Arg Ala Asn Val Val Ser Asn Val Arg Gln Gln Tyr Gln Ala Thr Gly 
 785                790                795                800
Phe Leu Trp Glu Gln Tyr Ser Asp Gln Asp Gly Arg Gly Met Gly Cys 
                 805                810                815
Arg Pro Phe Gln Gly Trp Thr Ser Leu Val Leu Leu Ile Met Ala Glu 
             820                825                830
Glu Tyr 
         835



<210> 1194
<211> 2866
<212> DNA
<213> Homo sapiens
<308> XM_035229
<400> 1194

ggaggcgga  gcgcaggcg  tggctggca  gtgtcgcta  ccggacggt  gtcgccagg  60
cgagaggcg  gagccggag  ggtgaggca  gacccgggc  ccactgccg  ctctccgag  120
tcttgtgac  cggacctca  tgccaggat  gctcggggc  agcggcggc  ccgcgcagt  180
ccggcagag  gagtgcgga  agccgagag  gcggctcgg  gaggccccg  gcgacggga  240
ggccggggc  gcgggccgc  tagcacggc  ggaggagtg  ctctggccg  cgtggtcct  300
tctttggcc  tgggtatgt  ggggcgctg  gtgctggcg  ggtaccgtg  gcggcgggc  360
gtcacgctg  actccgcgc  tcctgtgtt  cctgccgac  cctccagcc  cgccgtggc  420
ccggacctc  tctggggaa  ctaccgccc  cacgtctac  tcggcatga  gacccgcag  480
ccgaagccc  tcctcaccg  actgatgtg  gcgcagcag  gcaccaccc  ggggactcc  540
aagctcagg  acacgtgtg  gcaggggga  ggtgtgggt  cctatggct  ggagttcca  600
gacggcctc  ccttcgggc  ccaacacat  caggatggg  ccttaaggc  caccactga  660
ttcgtcaag  ggcctgggg  tcagcacgg  ggggactgg  gctggagag  gactgtaga  720
cctcaggac  caggtactt  tgccctccc  ttggtctcc  tgttcttct  tgtggtgac  780
gatggcaag  aagtcctac  accagaggt  ggggccaag  ggcagttga  gtttatcag  840
gggcacacc  gtgaacttg  tgacttccg  tttacactt  tgccaccaa  cagtccagg  900
gatacagcc  ccaagtatg  cagctacaa  gtcttctgg  cctccaacc  aggactgcc  960
ctgctgaca  agatggtaa  gagtcgcct  aatagctgg  ttcagcatc  gcccccagg  1020
gccccccct  aacgctacc  cggcttgcc  ggatccctg  agtgggagg  cagaggtcc  1080
agtgggcaa  ggcaggggc  gttcttgat  cagcaggtg  ccctgaaaa  tcccatttc  1140
atagagttt  tgtttgaat  aggcagtgc  caggcagga  gaaatcaag  cctgccaag  1200
ctggcaggc  gtctactga  ccaggccct  gagagccat  ctgaaggct  tagagagcg  1260
tttgagaag  ccttccagc  gaaggagaa  ggcctgagc  ctggcgagc  ggttttggg  1320
caggctgcc  tcagcggcc  ccttggtgg  attggctac  tctacggac  agggctggt  1380
ttgccagac  tcggggtgg  agggtctga  cagaaggtg  acccagccc  ctttccacc  1440
gtacctctt  ttacagcag  gccctcccg  tcattcttc  cacgaggct  cctttggga  1500
gaaggcttt  accagctgg  ggttcagcg  tgggatccc  ccctcaccc  ggaagccct  1560
ggccactgg  tggggctgc  aaatgctga  ggctggatt  ggagggagc  gatactggg  1620
gatgaggcc  gagcccggg  gcctccaga  ttcctagta  aacgagcag  ccacgccaa  1680
cccccaacc  tacttttgc  tgtagccca  atgctagag  ttggtgacc  tgacgactt  1740
gctttcctc  gaaaggcct  gccccgcct  catgcctgg  tttcctggc  ccatcagag  1800
caggcaggc  cactgccac  atcttaccg  tggcgggga  gggaccctg  cttaccaac  1860
ttactgaac  ccaagaccc  accctctgg  ctggatgac  acccccggg  ttcacaccc  1920
tcagtaacc  agcggcacc  ggacctgcg  tgttgggtg  cactgggtg  ccgtgtgct  1980
acgcggctg  cagagcatc  gggtgaggc  gaggtagct  ctgagctgg  cccactggc  2040
gcctcactg  aggcagcag  gagcctgga  gagctgcac  gggccccag  gctaggagt  2100
tttgcagac  ttgggaacc  cacaaaagc  gtacagctg  agcccaggc  ccctcaggg  2160
ctcgttcgg  tggtgggtc  gccccaacc  caactgcag  atgtagatg  tcttggcta  2220
gtcagtctt  ttcccttgc  gctgcgact  ctggacccc  cctcatccc  ccttgggcc  2280
ctgctggac  ttctagccg  cagccgcca  ctctggagc  cctttggtt  acgctccct  2340
gcagcctcc  gctcctttt  tggccagcg  aattcagag  atgatcccc  ctactggcg  2400
ggtgctgtg  ggctcaatg  caactacct  gctttggga  cactccacc  ctatgggca  2460
ctggagggt  ctcaccagg  tcgggctgc  aaactccac  gtgagctcc  tgccaacgt  2520
gtaggcaat  tatggcgcc  gtaccaggc  acaggcttt  tttgggagc  gtacagtga  2580
cgcgatggg  gaggcatgg  ctgccgccc  ttccacggc  ggaccagcc  tgtcttact  2640
gccatggct  aagactact  aagggaggg  gaggagggg  gccaagaca  tcatgccac  2700
ctggctctg  agggacaaa  gcttctggc  tttgccccc  gccccttgg  taccagtaa  2760
tcaaacctt  ctcatttca  ctcaggtgt  tccttgctg  catcccaca  agccctggg  2820
tgaatgtga  tccagagtc  atttttcta  ataaattgg  aaaaac  2866



<210> 1195
<211> 837
<212> PRT
<213> Homo sapiens
<308> XP_035229
<400> 1195

Met Ala Arg Gly Glu Arg Arg Arg Arg Ala Val Pro Ala Glu Gly Val 
  1               5                  10                  15
Arg Thr Ala Glu Arg Ala Ala Arg Gly Gly Pro Gly Arg Arg Asp Gly 
             20                  25                  30
Arg Gly Gly Gly Pro Arg Ser Thr Ala Gly Gly Val Ala Leu Ala Val 
         35                  40                  45
Val Val Leu Ser Leu Ala Leu Gly Met Ser Gly Arg Trp Val Leu Ala 
     50                  55                  60
Trp Tyr Arg Ala Arg Arg Ala Val Thr Leu His Ser Ala Pro Pro Val 
 65                  70                  75                  80
Leu Pro Ala Asp Ser Ser Ser Pro Ala Val Ala Pro Asp Leu Phe Trp 
                 85                  90                  95
Gly Thr Tyr Arg Pro His Val Tyr Phe Gly Met Lys Thr Arg Ser Pro 
             100                105                110
Lys Pro Leu Leu Thr Gly Leu Met Trp Ala Gln Gln Gly Thr Thr Pro 
         115                120                125
Gly Thr Pro Lys Leu Arg His Thr Cys Glu Gln Gly Asp Gly Val Gly 
     130                135                140
Pro Tyr Gly Trp Glu Phe His Asp Gly Leu Ser Phe Gly Arg Gln His 
 145                150                155                160
Ile Gln Asp Gly Ala Leu Arg Leu Thr Thr Glu Phe Val Lys Arg Pro 
                 165                170                175
Gly Gly Gln His Gly Gly Asp Trp Ser Trp Arg Val Thr Val Glu Pro 
             180                185                190
Gln Asp Ser Gly Thr Ser Ala Leu Pro Leu Val Ser Leu Phe Phe Tyr 
         195                200                205
Val Val Thr Asp Gly Lys Glu Val Leu Leu Pro Glu Val Gly Ala Lys 
     210                215                220
Gly Gln Leu Lys Phe Ile Ser Gly His Thr Ser Glu Leu Gly Asp Phe 
 225                230                235                240
Arg Phe Thr Leu Leu Pro Pro Thr Ser Pro Gly Asp Thr Ala Pro Lys 
                 245                250                255
Tyr Gly Ser Tyr Asn Val Phe Trp Thr Ser Asn Pro Gly Leu Pro Leu 
             260                265                270
Leu Thr Glu Met Val Lys Ser Arg Leu Asn Ser Trp Phe Gln His Arg 
         275                280                285
Pro Pro Gly Ala Pro Pro Glu Arg Tyr Leu Gly Leu Pro Gly Ser Leu 
     290                295                300
Lys Trp Glu Asp Arg Gly Pro Ser Gly Gln Gly Gln Gly Gln Phe Leu 
 305                310                315                320
Ile Gln Gln Val Thr Leu Lys Ile Pro Ile Ser Ile Glu Phe Val Phe 
                 325                330                335
Glu Ser Gly Ser Ala Gln Ala Gly Gly Asn Gln Ala Leu Pro Arg Leu 
             340                345                350
Ala Gly Ser Leu Leu Thr Gln Ala Leu Glu Ser His Ala Glu Gly Phe 
         355                360                365
Arg Glu Arg Phe Glu Lys Thr Phe Gln Leu Lys Glu Lys Gly Leu Ser 
     370                375                380
Ser Gly Glu Gln Val Leu Gly Gln Ala Ala Leu Ser Gly Leu Leu Gly 
 385                390                395                400
Gly Ile Gly Tyr Phe Tyr Gly Gln Gly Leu Val Leu Pro Asp Ile Gly 
                 405                410                415
Val Glu Gly Ser Glu Gln Lys Val Asp Pro Ala Leu Phe Pro Pro Val 
             420                425                430
Pro Leu Phe Thr Ala Val Pro Ser Arg Ser Phe Phe Pro Arg Gly Phe 
         435                440                445
Leu Trp Asp Glu Gly Phe His Gln Leu Val Val Gln Arg Trp Asp Pro 
     450                455                460
Ser Leu Thr Arg Glu Ala Leu Gly His Trp Leu Gly Leu Leu Asn Ala 
 465                470                475                480
Asp Gly Trp Ile Gly Arg Glu Gln Ile Leu Gly Asp Glu Ala Arg Ala 
                 485                490                495
Arg Val Pro Pro Glu Phe Leu Val Gln Arg Ala Val His Ala Asn Pro 
             500                505                510
Pro Thr Leu Leu Leu Pro Val Ala His Met Leu Glu Val Gly Asp Pro 
         515                520                525
Asp Asp Leu Ala Phe Leu Arg Lys Ala Leu Pro Arg Leu His Ala Trp 
     530                535                540
Phe Ser Trp Leu His Gln Ser Gln Ala Gly Pro Leu Pro Leu Ser Tyr 
 545                550                555                560
Arg Trp Arg Gly Arg Asp Pro Ala Leu Pro Thr Leu Leu Asn Pro Lys 
                 565                570                575
Thr Leu Pro Ser Gly Leu Asp Asp Tyr Pro Arg Ala Ser His Pro Ser 
             580                585                590
Val Thr Glu Arg His Leu Asp Leu Arg Cys Trp Val Ala Leu Gly Ala 
         595                600                605
Arg Val Leu Thr Arg Leu Ala Glu His Leu Gly Glu Ala Glu Val Ala 
     610                615                620
Ala Glu Leu Gly Pro Leu Ala Ala Ser Leu Glu Ala Ala Glu Ser Leu 
 625                630                635                640
Asp Glu Leu His Trp Ala Pro Glu Leu Gly Val Phe Ala Asp Phe Gly 
                 645                650                655
Asn His Thr Lys Ala Val Gln Leu Lys Pro Arg Pro Pro Gln Gly Leu 
             660                665                670
Val Arg Val Val Gly Arg Pro Gln Pro Gln Leu Gln Tyr Val Asp Ala 
         675                680                685
Leu Gly Tyr Val Ser Leu Phe Pro Leu Leu Leu Arg Leu Leu Asp Pro 
     690                695                700
Thr Ser Ser Arg Leu Gly Pro Leu Leu Asp Ile Leu Ala Asp Ser Arg 
 705                710                715                720
His Leu Trp Ser Pro Phe Gly Leu Arg Ser Leu Ala Ala Ser Ser Ser 
                 725                730                735
Phe Tyr Gly Gln Arg Asn Ser Glu His Asp Pro Pro Tyr Trp Arg Gly 
             740                745                750
Ala Val Trp Leu Asn Val Asn Tyr Leu Ala Leu Gly Ala Leu His His 
         755                760                765
Tyr Gly His Leu Glu Gly Pro His Gln Ala Arg Ala Ala Lys Leu His 
     770                775                780
Gly Glu Leu Arg Ala Asn Val Val Gly Asn Val Trp Arg Gln Tyr Gln 
 785                790                795                800
Ala Thr Gly Phe Leu Trp Glu Gln Tyr Ser Asp Arg Asp Gly Arg Gly 
                 805                810                815
Met Gly Cys Arg Pro Phe His Gly Trp Thr Ser Leu Val Leu Leu Ala 
             820                825                830
Met Ala Glu Asp Tyr 
         835



<210> 1196
<211> 708
<212> DNA
<213> Rattus norvegicus
<308> AF087697
<400> 1196

atgccagtg  tatcagaag  ctcgggttt  catgagacc  tggcactcc  cacctctca  60
ctcaggcct  actccaacc  cagggagga  atgggcttc  tgagggatg  cttcagtga  120
aagagcctc  gttacttaa  gaagattca  gagaaactc  gctattatg  gaggcagag  180
ccgaccccg  tcctacaca  cgccatggc  cttgctgag  atgtgatgg  ggaactgca  240
gctgcctcg  tgcacagcg  tgaacggga  ctgctacag  tgctgtcca  cccccacct  300
agggctgtg  tcatggtac  cgacacagt  gcccagaag  acttcgatc  tgttctgcc  360
cctctgcct  ataatatcg  cgaggattt  gaagaggaa  cagtgaaga  tgttcgcct  420
gtcaagaat  aggagcccc  gggtgccac  atccgaagg  atgagcatt  gggggctgt  480
gtggtggcc  ggatcatgc  agggggtgc  gcggatcgg  gcggtctgg  ccacgttgg  540
gacgagctc  gggaggtga  tgggatcac  gtcctgcac  aacgtccag  cgagatcag  600
caaattctg  cccaatccc  gggatccat  accctcaag  tcatccctg  cacccagga  660
gaagaccgc  tcaaagaga  caaggtgtt  atgcgtgcc  tcttctag  708



<210> 1197
<211> 235
<212> PRT
<213> Rattus norvegicus
<308> AAC78485
<400> 1197

Met Pro Val Leu Ser Glu Asp Ser Gly Leu His Glu Thr Leu Ala Leu 
  1               5                  10                  15
Leu Thr Ser Gln Leu Arg Pro Asp Ser Asn His Arg Glu Glu Met Gly 
             20                  25                  30
Phe Leu Arg Asp Val Phe Ser Glu Lys Ser Leu Gly Tyr Leu Met Lys 
         35                  40                  45
Ile His Glu Lys Leu Arg Tyr Tyr Glu Arg Gln Ser Pro Thr Pro Val 
     50                  55                  60
Leu His Ser Ala Met Ala Leu Ala Glu Asp Val Met Glu Glu Leu Gln 
 65                  70                  75                  80
Ala Ala Ser Val His Ser Asp Glu Arg Glu Leu Leu Gln Leu Leu Ser 
                 85                  90                  95
Thr Pro His Leu Arg Ala Val Leu Met Val His Asp Thr Val Ala Gln 
             100                105                110
Lys Asn Phe Asp Pro Val Leu Pro Pro Leu Pro Asp Asn Ile Asp Glu 
         115                120                125
Asp Phe Glu Glu Glu Ser Val Lys Ile Val Arg Leu Val Lys Asn Lys 
     130                135                140
Glu Pro Leu Gly Ala Thr Ile Arg Arg Asp Glu His Ser Gly Ala Val 
 145                150                155                160
Val Val Ala Arg Ile Met Arg Gly Gly Ala Ala Asp Arg Ser Gly Leu 
                 165                170                175
Val His Val Gly Asp Glu Leu Arg Glu Val Asn Gly Ile Thr Val Leu 
             180                185                190
His Lys Arg Pro Asp Glu Ile Ser Gln Ile Leu Ala Gln Ser Gln Gly 
         195                200                205
Ser Ile Thr Leu Lys Ile Ile Pro Ala Thr Gln Glu Glu Asp Arg Phe 
     210                215                220
Lys Glu Ser Lys Val Phe Met Arg Ala Leu Phe 
 225                230                235



<210> 1198
<211> 3012
<212> DNA
<213> Homo sapiens
<308> U37707
<400> 1198

agcttccac  ccgctgttt  ttcatcaat  aaatgggaa  attcgcagt  atttctcag  60
actttgtgc  gacaaaaag  ttatcatag  aatcacccc  cacaatgct  ggcacatcg  120
ggacactca  cacatctta  ctttatttc  ttcctctct  aaaaaagta  gcagagtta  180
ttgttccca  cctctctgt  cacagcctg  tctcagaga  cacagtaga  gtgtagtca  240
tttgttcaa  aaatatgct  gatggagct  caataccca  ctccacccc  ttctnccag  300
atctgcagg  agaggtcgg  aggtgacaa  gccagcatg  cagtgctat  ggaggactc  360
ggtttgcat  aaaccctgg  cctgctgac  tcccagctc  gacctgact  caaccacaa  420
gaggagatg  gcttcctga  ggatgattt  agtgaaaaa  gcctcagtt  cttaatgaa  480
attcatgag  agcttcgct  ttatgaaag  caaagtcca  ccccagttc  gcacagcgc  540
gtggccctc  ctgaggacg  gatggagga  ttgcaggcc  cctccgtgc  cagtgatga  600
agggagctg  tccagctgc  gtccacccc  cacctgagg  ctgtgctca  ggtacatga  660
acggttgcc  agaagaatt  tgaccccgt  ctcccgcct  tgcctgaca  tatcgatga  720
gattttgat  aggaatcgg  gaagatcgt  cgcttggtg  agaacaagg  acccctggg  780
gccaccatc  ggcgggacg  gcactcagg  gctgttgtg  tggccagga  catgcgagg  840
ggcgcagca  acaggagcg  cctggtcca  gttggagat  agctccgag  agtgaacgg  900
atcgcagtc  tgcacaagc  gcccgacga  atcagccag  ttctggccc  gtcccaggg  960
tccatcacc  taaaaatca  cccagccac  caggaggaa  atcgcttaa  ggagagcaa  1020
gtgttcatg  gcgccctct  ccactacaa  cctcgggag  accgggcca  cccttgcca  1080
gaggcgggc  tgcccttcc  gcgcaggca  gtcctggag  tggtgagcc  ggacgaccc  1140
acgtggtgg  aggccaagc  agtcgggga  accaacctt  gagccggsc  catcccctc  1200
aaggggttc  aggagagac  actaagcta  cggagagcc  cgggcaccc  gccgagccc  1260
cagagcctc  ggaagcccc  ctatgatca  ccttgtgac  aagagacct  tgactgtga  1320
ggctacctc  aagggcact  tgtggctgg  cttcggagg  gcttccggc  gggctgtag  1380
gagagactg  gtggctcgc  ggaaggaaa  atgtcctcc  gagctgagt  tccggagct  1440
ctgacttac  aagaggtgg  caggtacca  caccagccc  gagagcggc  ccgcctggt  1500
gttctgatc  ggtctctgg  agcccgact  cacgagctg  agcaaaagg  ggtggctga  1560
aacccacag  actttggcg  cgctgttcc  cataccacc  ggccccgaa  gagccatga  1620
aaggaagga  tggaatatc  ctttgtgtc  aagcaagca  ttgaggccg  cttacatca  1680
aacaagttc  tggaacatg  tgaatataa  gaaaatctg  atggaacca  cctggaggc  1740
attcaggct  ttatggcca  aaacaaagt  tgtttggtg  atgtggagc  agaagcact  1800
aaacaactg  ggacctcag  atttaaacc  tatattata  ttgtaaagc  tgcaattca  1860
gaaaaaaga  aaacgccac  tatgtcccc  gcttgtgag  acacagcag  cccatttga  1920
gagcagcag  aagagatgg  cgcttctgc  gccttcata  accggcatt  cgggcacct  1980
gtagacgcc  tgctggtga  ggaggatct  cagggtgcc  acagccagc  caaagtggt  2040
ttagagaag  tgagcaagg  cactcactg  gtacctgtt  gttgggtca  gtaacttta  2100
cccagaaca  ccaagctgg  cgggacctt  aagatcatc  agtccagac  ccctcattt  2160
accatcaag  aatctcaag  gcagagagg  agagaattc  ccacaaatt  catcatcga  2220
aagagtata  gtgggaagt  ttgtttgtt  ttggttttt  tctgttgtt  ttcactgca  2280
ctctttgga  catgatttg  aaggggcat  tcagaaaac  acacatttc  tttattaaa  2340
tatcacagg  aagctgacc  tgattcttt  taccaaagt  aagtagcca  tgtcttttg  2400
gggtggtag  ggttaattt  tacagtact  attcgcaga  tgtttaagc  ttttaaaca  2460
agtgacgct  agtagtttt  ttggaagct  acttgtttt  tccaggggg  ttttacatg  2520
aactgaagt  cccctgtct  caagcacta  aacgttgat  ttaaccttt  ttttgaagt  2580
cttgcctgg  aatagaaaa  gggttctct  cctatttta  aatagtgaa  atacgtaaa  2640
tttctctgg  aggctgagg  acacttcac  atcaacatg  attactgta  tatcctgta  2700
tgcagtggt  ccttcaggg  ctcgaggaa  gtaaggttg  ctttcccct  tctaaatac  2760
ctcagattc  taacatcga  cccatgctt  gtttgattt  ttctattcc  tccattgtc  2820
cttttgtta  tgacagttg  cttggtcct  gccagtccc  gccatgaga  cataggggt  2880
cccattgtg  tagatcttg  gaaaccaga  gactctccc  gtcaaaact  tggctacgt  2940
actgtaaac  atttctgtc  agaataaaa  tatgtagac  cagagtgtg  gcctaaaaa  3000
aaaaaaaaa  aa  3012



<210> 1199
<211> 585
<212> PRT
<213> Homo sapiens
<308> Q13368
<400> 1199

Met Pro Val Leu Ser Glu Asp Ser Gly Leu His Glu Thr Leu Ala Leu 
  1               5                  10                  15
Leu Thr Ser Gln Leu Arg Pro Asp Ser Asn His Lys Glu Glu Met Gly 
             20                  25                  30
Phe Leu Arg Asp Asp Phe Ser Glu Lys Ser Leu Ser Tyr Leu Met Lys 
         35                  40                  45
Ile His Glu Lys Leu Arg Tyr Tyr Glu Arg Gln Ser Pro Thr Pro Val 
     50                  55                  60
Leu His Ser Ala Val Ala Leu Ala Glu Asp Val Met Glu Glu Leu Gln 
 65                  70                  75                  80
Ala Ala Ser Val His Ser Asp Glu Arg Glu Leu Leu Gln Leu Leu Ser 
                 85                  90                  95
Thr Pro His Leu Arg Ala Val Leu Met Val His Asp Thr Val Ala Gln 
             100                105                110
Lys Asn Phe Asp Pro Val Leu Pro Pro Leu Pro Asp Asn Ile Asp Glu 
         115                120                125
Asp Phe Asp Glu Glu Ser Val Lys Ile Val Arg Leu Val Lys Asn Lys 
     130                135                140
Glu Pro Leu Gly Ala Thr Ile Arg Arg Asp Glu His Ser Gly Ala Val 
 145                150                155                160
Val Val Ala Arg Ile Met Arg Gly Gly Ala Ala Asp Arg Ser Gly Leu 
                 165                170                175
Val His Val Gly Asp Glu Leu Arg Glu Val Asn Gly Ile Ala Val Leu 
             180                185                190
His Lys Arg Pro Asp Glu Ile Ser Gln Ile Leu Ala Gln Ser Gln Gly 
         195                200                205
Ser Ile Thr Leu Lys Ile Ile Pro Ala Thr Gln Glu Glu Asp Arg Leu 
     210                215                220
Lys Glu Ser Lys Val Phe Met Arg Ala Leu Phe His Tyr Asn Pro Arg 
 225                230                235                240
Glu Asp Arg Ala Ile Pro Cys Gln Glu Ala Gly Leu Pro Phe Gln Arg 
                 245                250                255
Arg Gln Val Leu Glu Val Val Ser Gln Asp Asp Pro Thr Trp Trp Gln 
             260                265                270
Ala Lys Arg Val Gly Asp Thr Asn Leu Arg Ala Gly Leu Ile Pro Ser 
         275                280                285
Lys Gly Phe Gln Glu Arg Arg Leu Ser Tyr Arg Arg Ala Ala Gly Thr 
     290                295                300
Leu Pro Ser Pro Gln Ser Leu Arg Lys Pro Pro Tyr Asp Gln Pro Cys 
 305                310                315                320
Asp Lys Glu Thr Cys Asp Cys Glu Gly Tyr Leu Lys Gly His Tyr Val 
                 325                330                335
Ala Gly Leu Arg Arg Ser Phe Arg Leu Gly Cys Arg Glu Arg Leu Gly 
             340                345                350
Gly Ser Gln Glu Gly Lys Met Ser Ser Gly Ala Glu Ser Pro Glu Leu 
         355                360                365
Leu Thr Tyr Glu Glu Val Ala Arg Tyr Gln His Gln Pro Gly Glu Arg 
     370                375                380
Pro Arg Leu Val Val Leu Ile Gly Ser Leu Gly Ala Arg Leu His Glu 
 385                390                395                400
Leu Lys Gln Lys Val Val Ala Glu Asn Pro Gln His Phe Gly Val Ala 
                 405                410                415
Val Pro His Thr Thr Arg Pro Arg Lys Ser His Glu Lys Glu Gly Val 
             420                425                430
Glu Tyr His Phe Val Ser Lys Gln Ala Phe Glu Ala Asp Leu His His 
         435                440                445
Asn Lys Phe Leu Glu His Gly Glu Tyr Lys Glu Asn Leu Tyr Gly Thr 
     450                455                460
Ser Leu Glu Ala Ile Gln Ala Val Met Ala Lys Asn Lys Val Cys Leu 
 465                470                475                480
Val Asp Val Glu Pro Glu Ala Leu Lys Gln Leu Arg Thr Ser Glu Phe 
                 485                490                495
Lys Pro Tyr Ile Ile Phe Val Lys Pro Ala Ile Gln Glu Lys Arg Lys 
             500                505                510
Thr Pro Pro Met Ser Pro Ala Cys Glu Asp Thr Ala Ala Pro Phe Asp 
         515                520                525
Glu Gln Gln Gln Glu Met Ala Ala Ser Ala Ala Phe Ile Asp Arg His 
     530                535                540
Tyr Gly His Leu Val Asp Ala Val Leu Val Lys Glu Asp Leu Gln Gly 
 545                550                555                560
Ala Tyr Ser Gln Leu Lys Val Val Leu Glu Lys Leu Ser Lys Asp Thr 
                 565                570                575
His Trp Val Pro Val Ser Trp Val Arg 
             580                585



<210> 1200
<211> 1450
<212> DNA
<213> Rattus norvegicus
<308> AF087944
<400> 1200

ctcgagctg  cctgcctct  cctcctaaa  gctgggatt  aaggcatgc  cctctagcc  60
agctagctt  ttaaagaaa  gtattgaac  agctggaca  ggcgactca  acctataat  120
ctagcgttt  ggaggcaga  gcaggagga  aattgccag  tccaggcta  gctagactg  180
gctactaga  tgagagacc  tggggagaa  ggagaggta  agagtgaga  aagaatgaa  240
taataaaca  cggagtgaa  agggagaag  gagaactgt  tttcatatt  actctcaac  300
ttgagctgt  ttctgcctc  ggaacccat  gatgagttc  caatctttc  acaagtgtc  360
agttacact  aaaaaaaaa  aaaaatcaa  ggcttggat  cggacggtg  aaaattgct  420
gtactatga  tatggggga  atggagttg  actgatggg  ctgagcaaa  gaatactga  480
ctaggggct  gggatttag  tcagtggta  agcgcttac  taggaagcg  aaggccctg  540
gttcggtcc  cagctccga  aaaaagaac  aaaaaaaaa  aaaaaaaaa  gaatactga  600
ctaaggcac  gtgtgattc  cccttttcc  gtatgtacc  gacaagccc  gggcgcctc  660
gtcatcctc  tggcacaga  tgccctaat  ccacttaga  ttcttcctg  ttccgtccc  720
ccctgcaaa  catttcatt  caatattta  tagaagtga  tagggttgt  aggaggaag  780
gaagtgggg  agcaagttg  gttcacaga  gaagggaca  ggtgacatc  caggattac  840
taaacttac  ggggctgcc  aattggtca  accagcctg  gtaacctag  agccagaga  900
cgctgctgt  aaggaaaga  actgaagcc  ttctcggag  ctgtctggg  tgctcccac  960
ctcagaatc  accgaccat  gtgagtcag  ctgtcttgg  gtggaactg  agccaacct  1020
aggaattca  gatctggct  gaatttctg  ccctttctt  ctctcagaa  cttatgctc  1080
gcttgttgc  gttgccttt  acactggtg  atgcctctc  cgccacacc  gaaccctgt  1140
agctggacc  ggacgagga  agtgtccgc  gctactgca  cttctcaga  ccgcagccc  1200
attggtcca  cgcttttct  tgcgcgggg  cggaagacg  ggagttcta  ggcggcggt  1260
gcagcctgg  gtaccttct  aagcgtgtg  acacggaag  aaatctggg  cagtacact  1320
atattatca  gtctctgcc  ttgaagagg  ttactgtgc  gtccgcgcg  gttcctact  1380
agattctat  cggaaccct  cgtgtgctc  gatattctg  cctccggga  ctgactctt  1440
aaaactcgag  1450



<210> 1201
<211> 128
<212> PRT
<213> Rattus norvegicus
<308> AAC35372
<400> 1201

Met Lys Leu Met Leu Gly Leu Leu Leu Leu Pro Leu Thr Leu Val His 
  1               5                  10                  15
Ala Ser Pro Ala Thr Pro Glu Pro Cys Glu Leu Asp Gln Asp Glu Glu 
             20                  25                  30
Ser Val Arg Cys Tyr Cys Asn Phe Ser Asp Pro Gln Pro Asn Trp Ser 
         35                  40                  45
Ser Ala Phe Leu Cys Ala Gly Ala Glu Asp Val Glu Phe Tyr Gly Gly 
     50                  55                  60
Gly Arg Ser Leu Glu Tyr Leu Leu Lys Arg Val Asp Thr Glu Ala Asn 
 65                  70                  75                  80
Leu Gly Gln Tyr Thr Asp Ile Ile Arg Ser Leu Pro Leu Lys Arg Leu 
                 85                  90                  95
Thr Val Arg Ser Ala Arg Val Pro Thr Gln Ile Leu Phe Gly Thr Leu 
             100                105                110
Arg Val Leu Gly Tyr Ser Gly Leu Arg Glu Leu Thr Leu Glu Asn Ser 
         115                120                125



<210> 1202
<211> 1570
<212> DNA
<213> Homo sapiens
<308> X06882
<400> 1202

cagaatgac  tcccaggat  acataaact  tcagaggca  ccgaagagt  cacaagtgt  60
aagcctgga  gccggcggg  gccgctgtg  aggaaagaa  ctaaagcac  tccagagcc  120
gtccggagc  cagaggttc  gaagactta  cgaccatgg  gagtgtagg  tcttggggt  180
gaacgcgtg  cactcggga  ccacagggg  tggatgggg  ctcctagac  tctgctctc  240
ccccaggag  gcgcgtcct  cttgttgct  ctgctgctg  cgctggtgc  cgtctctgc  300
accacgcca  aaccttgtg  gctggacga  gaagatttc  gctgcgtct  caacttctc  360
gaacctcag  ccgactggt  cgaagcctt  cagtgtgtg  ctgcagtag  ggtggagat  420
catgccggc  gtctcaacc  agagccgtt  ctaaagcgc  tcgatgcgg  cgccgaccc  480
cggcagtat  ctgacacgg  caaggctct  cgcgtgcgg  ggctcacag  gggagccgc  540
caggttcct  ctcagctac  ggtaggcgc  ctgcgtgtg  tagcgtact  ccgcctcaa  600
gaactgacg  tcgaggacc  aaagataac  ggcaccatg  ctccgctgc  tctggaagc  660
acaggactt  cactttcca  cttgcgcct  cgcaacgtg  cgtgggcga  agggcgttc  720
tggctcgcc  agctgcagc  gtggctcaa  ccaggcctc  aggtactga  cattgccca  780
gcacactcg  ctgcctttt  ctacgaaca  gttcgcgcc  tcccggccc  taccagcct  840
gacctgtct  acaatcctg  actgggcga  cgcggactg  tggcggctc  ctgtcccca  900
aagttcccg  ccatccaga  tctagcgct  cgcaacaca  gaatggaga  gcccacagg  960
gtgtgcgcc  cactggcgg  ggcaggtgt  cagccccac  gcctagacc  cagccacaa  1020
tcgctgcgc  ccaccgtaa  ccctagcgc  ccgagatgc  tgtggtcca  cgccctgaa  1080
tccctcaat  tgtcgttcg  tgggctgga  caggtgcct  aaggactgc  agccaagct  1140
agagtgctc  atctcagct  caacagact  aacagggcg  cgcagcctg  cgagctgcc  1200
gaggtggat  acctgacac  ggacgggaa  cccttcctg  tccctggaa  tgccctccc  1260
cacgagggc  caatgaact  cggcgtggt  ccagcctgt  cacgttcga  cctgtcggt  1320
ggggtgtcg  gaaccctgg  gctgctcca  ggggcccgg  gctttgcct  agatccaag  1380
cagaataat  aatggactc  aactgcctt  gcttcaggg  agtcccgtc  ggacgttga  1440
gacttttcg  ccaattcaa  cctttgccc  acctttatt  aaatcttaa  caacggttc  1500
gtgtcattc  tttaacaga  ctttattgg  tgtctgcta  gtgctgggc  cagtactgg  1560
tggggaattc  1570



<210> 1203
<211> 375
<212> PRT
<213> Homo sapiens
<308> CAA29999
<400> 1203

Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
  1               5                  10                  15
Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
             20                  25                  30
Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
         35                  40                  45
Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
     50                  55                  60
Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
 65                  70                  75                  80
Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 
                 85                  90                  95
Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
             100                105                110
Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile 
         115                120                125
Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu 
     130                135                140
Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp 
 145                150                155                160
Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 
                 165                170                175
Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 
             180                185                190
Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 
         195                200                205
Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile 
     210                215                220
Gln Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val 
 225                230                235                240
Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu 
                 245                250                255
Ser His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys 
             260                265                270
Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu 
         275                280                285
Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu 
     290                295                300
Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu 
 305                310                315                320
Val Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr 
                 325                330                335
Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys 
             340                345                350
Ala Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu 
         355                360                365
Gln Gly Ala Arg Gly Phe Ala 
     370                375



<210> 1204
<211> 570
<212> DNA
<213> Rattus norvegicus
<308> AF090134
<400> 1204

atggcgaca  tgacagtgg  ccagccgct  actctggac  gagatgttg  aagagcaat  60
gaactacta  aaaagctac  agaatccgg  gaagtacca  tgcacaagc  gcagtctct  120
aaaaaggtg  ttcagagtg  gttttgtac  gcaatccga  aggtgtatc  atacatgca  180
gaaacgatt  ctgttaatg  ctgccctga  ttccgtgcg  gggccacag  aaaggcaac  240
gttgcggct  ttgcagcca  cgaaggcca  tcccaccct  gggtagtcg  actgccaaa  300
actgatgaa  gcctgggtt  taacgtgat  ggaggaaag  aacagaatt  tccaattta  360
atctcccgc  tcatccctg  aggggtggc  gaaagacac  gaggcctca  aagaggaga  420
cagttgcta  cagtgaacg  agtggccct  gaagaaaag  tagcaggtc  atcatccaa  480
agtcacaaa  ttgggaacc  gtgctccgg  atcccagca  atagaaaaa  gaaaagaaa  540
taccagtaa  cacctgtca  aaaactgtga  570



<210> 1205
<211> 182
<212> PRT
<213> Rattus norvegicus
<308> AAC78073
<400> 1205

Met Ala Thr Leu Thr Val Val Gln Pro Leu Thr Leu Asp Arg Asp Val 
  1               5                  10                  15
Ala Arg Ala Ile Glu Leu Leu Glu Lys Leu Gln Glu Ser Gly Glu Val 
             20                  25                  30
Pro Val His Lys Leu Gln Ser Leu Lys Lys Val Leu Gln Ser Glu Phe 
         35                  40                  45
Cys Thr Ala Ile Arg Glu Val Tyr Gln Tyr Met His Glu Thr Ile Thr 
     50                  55                  60
Val Asn Gly Cys Pro Glu Phe Arg Ala Arg Ala Thr Ala Lys Ala Thr 
 65                  70                  75                  80
Val Ala Ala Phe Ala Ala Ser Glu Gly His Ser His Pro Arg Val Val 
                 85                  90                  95
Glu Leu Pro Lys Thr Asp Glu Gly Leu Gly Phe Asn Val Met Gly Gly 
             100                105                110
Lys Glu Gln Asn Ser Pro Ile Tyr Ile Ser Arg Ile Ile Pro Gly Gly 
         115                120                125
Val Ala Glu Arg His Gly Gly Leu Lys Arg Gly Asp Gln Leu Leu Ser 
     130                135                140
Val Asn Gly Val Ala Leu Glu Glu Lys Leu Ala Gly Gln Ser Ser Asn 
 145                150                155                160
Ser His Lys Phe Gly Asn Pro Cys Ser Gly Ile Pro Ala His Arg Lys 
                 165                170                175
Arg Lys Arg Lys Tyr Gln 
             180



<210> 1206
<211> 1176
<212> DNA
<213> Homo sapiens
<308> AF087693
<400> 1206

gccgcggaa  agttgcgtc  ccatctggc  accaaccca  ccaagcttt  ttctccacc  60
ccaccacct  ccttccttc  ccctcctcc  cctcctttc  gtcttccct  tccaccccc  120
cccccaatc  cctcctttt  ttctcacta  gagcggttg  tgatgctga  gccgagcgt  180
acttcggct  ccacggcag  catggcgac  ttgacagtg  tccagccgc  caccctgga  240
agagatgtt  caagagcaa  tgaattact  gaaaaacta  aggaatctg  agaagtacc  300
gtgcacaag  tacaatccc  caaaaaagt  cttcagagt  agttttgta  agctattcg  360
gaggtgtat  aatatatgc  tgaaacgat  actgttaat  gctgtcccg  attccgtgc  420
agggcaaca  caaaggcaa  agttgcagc  tttgcagct  gtgaaggcc  ctcccaccc  480
cgagtagtt  aactgccaa  gactgatga  ggccttggt  ttaatgtga  gggaggaaa  540
gagcaaaat  cccccattt  tatctctcg  ataattcct  gaggggtgg  tgaaagaca  600
ggaggcctc  aaagaggag  ccagctgct  tcagtgaac  gagtgagtg  ggaaggaga  660
caccatgag  aagctgtgg  actactcaa  gctgctaaa  acagcgtca  gctggtggt  720
cgatacacc  caaaagttc  ggaagaaat  gaggctcgc  ttgaaaagc  acgaacagc  780
aggcgtcgg  agcagcagc  attgctaat  cagcagcag  aacagcagc  gcagcaaca  840
acacaacaa  accacatgt  ataggccct  gagggaaag  tacttgatc  aacatccga  900
agtcacaaa  ttgaaaccg  gcttcagaa  cccagcaca  agtaaaaga  aacactgat  960
attatacct  tcaagaagc  gtgaacaca  ggtgtataa  ttctttacc  aggcaactc  1020
acaccttct  tctctgggc  tgaaccgcc  ctgctcacg  gggctttac  tacattgac  1080
ttccattca  tgcagtggg  attctcagt  tgcagaggg  gaggttttc  agtctgcaa  1140
ctgaaacag  gtaagaaga  taaagtcta  gacttt  1176



<210> 1207
<211> 233
<212> PRT
<213> Homo sapiens
<308> NP_004655
<400> 1207

Met Leu Lys Pro Ser Val Thr Ser Ala Pro Thr Ala Asp Met Ala Thr 
  1               5                  10                  15
Leu Thr Val Val Gln Pro Leu Thr Leu Asp Arg Asp Val Ala Arg Ala 
             20                  25                  30
Ile Glu Leu Leu Glu Lys Leu Gln Glu Ser Gly Glu Val Pro Val His 
         35                  40                  45
Lys Leu Gln Ser Leu Lys Lys Val Leu Gln Ser Glu Phe Cys Thr Ala 
     50                  55                  60
Ile Arg Glu Val Tyr Gln Tyr Met His Glu Thr Ile Thr Val Asn Gly 
 65                  70                  75                  80
Cys Pro Glu Phe Arg Ala Arg Ala Thr Ala Lys Ala Thr Val Ala Ala 
                 85                  90                  95
Phe Ala Ala Ser Glu Gly His Ser His Pro Arg Val Val Glu Leu Pro 
             100                105                110
Lys Thr Asp Glu Gly Leu Gly Phe Asn Val Met Gly Gly Lys Glu Gln 
         115                120                125
Asn Ser Pro Ile Tyr Ile Ser Arg Ile Ile Pro Gly Gly Val Ala Glu 
     130                135                140
Arg His Gly Gly Leu Lys Arg Gly Asp Gln Leu Leu Ser Val Asn Gly 
 145                150                155                160
Val Ser Val Glu Gly Glu His His Glu Lys Ala Val Glu Leu Leu Lys 
                 165                170                175
Ala Ala Lys Asp Ser Val Lys Leu Val Val Arg Tyr Thr Pro Lys Val 
             180                185                190
Leu Glu Glu Met Glu Ala Arg Phe Glu Lys Leu Arg Thr Ala Arg Arg 
         195                200                205
Arg Gln Gln Gln Gln Leu Leu Ile Gln Gln Gln Gln Gln Gln Gln Gln 
     210                215                220
Gln Gln Thr Gln Gln Asn His Met Ser 
 225                230



<210> 1208
<211> 2766
<212> DNA
<213> Rattus norvegicus
<308> AF091247
<400> 1208

tgactcccc  tccgacctc  cctgccccc  gggaggccc  cctttgcct  cttttgggg  60
ggtgggcgg  gaggggcgc  cggatcatg  cattggagt  cccgggctt  cagccgccg  120
cgccgcctc  tccacgtac  ccaagcgct  cttcttccc  gagcagcag  ggagaaggc  180
aagcgccca  tgggggcga  gcagatggg  ctcaaggct  gcagggcat  gggctcctg  240
caaagaccc  cctgagccg  ccagttaag  ggaacaacg  caagtacag  cgcatccaa  300
ctttgatct  tgacgccct  gagagaccg  ggggctggg  gctgctcta  cacgcgctt  360
tgttcctga  tgtcctggg  tgcttgatt  tggccgtgc  caccacttt  aaggagtat  420
agactgtgt  tggagactg  cttttgctg  tggaaacat  tgctatttt  atctttgga  480
ctgagtttg  tttgaggat  tgggctgca  gatgttgct  tcgatacaa  ggctggcgt  540
gacggctga  gtttgccag  aagcccctg  gcatgttgg  tatcttcgt  ctgattgct  600
ctgtgccag  ggttgccgt  ggaaaccag  gcaatgtcc  ggctacctc  ctgcgaagc  660
tccgcttcc  gcagatcct  cgcatgctt  gaatggata  gaggggtgg  acctggaag  720
tcctgggct  agctatctg  gcccacagc  aagaactca  caccgcctg  tacatcggc  780
tcctgacac  catcctttc  tcatttctt  tctacctgg  ggagaagga  gtgccagag  840
tggatgccc  aggagagga  atgaaagag  agtttgaga  ctatgctga  gccctgtgg  900
ggggcctga  cacactggc  accattggt  atggagaca  gacacctaa  acctgggaa  960
gacgtctga  tgctgccac  ttttcttta  tcggcgtct  cttttttgc  cttccggca  1020
gcatccttg  ctcaggact  gcattgaag  ttcaggaac  gcaccgtca  aagcacttt  1080
agaagagaa  gaagccagc  gctgaactc  tccaggctg  ctggagata  tatgctacc  1140
accccaaca  gcttgacct  gtggcaacc  ggagatttt  tgaatcagt  gtctctttc  1200
cattcttca  gaaagaaca  ctggaagca  cagccagcc  aaagctggg  ctcttggat  1260
gggttcgcc  ttctaatcc  cgtggtagc  atactaaag  aaagctatt  acccctctg  1320
atgtagatg  catagaaga  agcccttcc  aagagccaa  gcccgttgg  ttaaacaat  1380
aagagcgtt  ccgcaccgc  ttccgcatg  aagcctacg  tttctggca  agttctgaa  1440
atgccggga  aggagaccc  atgacagaa  acaggggct  tggaaatga  ttcctcatt  1500
aagacatga  ccccaccct  aaggctgcc  tccgagctg  cagaattct  caattccgt  1560
tgtataaaa  aaaattcaa  gagacattg  ggccttatg  tgtaaaaga  gtaattgag  1620
agtattccg  tggacatct  gacatgctt  ccaggataa  gtaccttca  acaagaata  1680
atatgattt  cacccctgg  cctccatcc  ctccaaaac  taagaagtc  cagaaaggg  1740
cagcattta  ctacccatc  cagcagtct  caaggaatg  accatatgt  gccagggca  1800
ccacatcag  aactgaaga  caaagcatg  tggggaagt  tgtaaaagt  gaaagacag  1860
ttcacgaca  ggggaagaa  ctggacttc  tcgtggaca  gcacatgca  catatggag  1920
gtctgcagg  gcgcgtcac  gagtactac  caacaaagg  ggcctcctc  ccagcagaa  1980
gggagaaga  agaggacaa  aggtattct  acttgaaaa  catcatctg  aactactca  2040
aatcaggcc  ccccgaccc  ccctacagc  tccaccagg  gcccatcga  agagttggt  2100
cctatgggt  ttttgcaca  gaccccgtg  aactgacca  agggggacc  agttctaca  2160
aggctcagg  caaccttcc  tcctcggga  gtacatatg  agagaggcc  acagtcctg  2220
ccatcttga  tcttctgga  tcatgtgtg  gctaccact  ccagacaga  ctgcaaggc  2280
cctattcgg  ccacatctc  ccccgccag  gacgcagca  cactaggga  agtgacaca  2340
cactgtccc  catgtccgt  aaccacgag  aactggaac  gtctccaag  ggcttcagc  2400
tctcccaag  cagagatga  tatgtattt  gccccagtg  gggttcgag  tggatgagg  2460
aaaagcggt  cctggcaga  ggagaaaca  acacagata  agacccctt  acgcccagt  2520
gatccatgc  tatgtcatc  actggagat  gtatttcag  ttccatatg  accccttcc  2580
acaagccca  ttagaaggg  tcactggct  actcctggt  ctgtagtca  actttgtac  2640
gctcactta  tctcacatc  agtgcttaa  aatgaggac  ccagtggct  tgtcaagcg  2700
atgcatgtg  gcggtggcc  ccctgcaag  aggggcttc  cacagcctt  ttcctcccc  2760
tgtcac  2766



<210> 1209
<211> 873
<212> PRT
<213> Rattus norvegicus
<308> O88944
<400> 1209

Met Gly Leu Lys Ala Arg Arg Ala Ala Gly Ala Ala Gly Gly Gly Gly 
  1               5                  10                  15
Gly Glu Gly Gly Gly Gly Gly Gly Gly Ala Ala Asn Pro Ala Gly Gly 
             20                  25                  30
Asp Ser Ala Val Ala Gly Asp Glu Glu Arg Lys Val Gly Leu Ala Pro 
         35                  40                  45
Gly Asp Val Glu Gln Val Thr Leu Ala Leu Gly Thr Gly Ala Asp Lys 
     50                  55                  60
Asp Gly Thr Leu Leu Leu Glu Gly Gly Gly Arg Glu Glu Gly Gln Arg 
 65                  70                  75                  80
Arg Thr Pro Gln Gly Ile Gly Leu Leu Ala Lys Thr Pro Leu Ser Arg 
                 85                  90                  95
Pro Val Lys Arg Asn Asn Ala Lys Tyr Arg Arg Ile Gln Thr Leu Ile 
             100                105                110
Tyr Asp Ala Leu Glu Arg Pro Arg Gly Trp Ala Leu Leu Tyr His Ala 
         115                120                125
Leu Val Phe Leu Ile Val Leu Gly Cys Leu Ile Leu Ala Val Leu Thr 
     130                135                140
Thr Phe Lys Glu Tyr Glu Thr Val Ser Gly Asp Trp Leu Leu Leu Leu 
 145                150                155                160
Glu Thr Phe Ala Ile Phe Ile Phe Gly Ala Glu Phe Ala Leu Arg Ile 
                 165                170                175
Trp Ala Ala Gly Cys Cys Cys Arg Tyr Lys Gly Trp Arg Gly Arg Leu 
             180                185                190
Lys Phe Ala Arg Lys Pro Leu Cys Met Leu Asp Ile Phe Val Leu Ile 
         195                200                205
Ala Ser Val Pro Val Val Ala Val Gly Asn Gln Gly Asn Val Leu Ala 
     210                215                220
Thr Ser Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met Leu Arg 
 225                230                235                240
Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Ala Ile Cys 
                 245                250                255
Ala His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile Gly Phe Leu Thr 
             260                265                270
Leu Ile Leu Ser Ser Phe Leu Val Tyr Leu Val Glu Lys Asp Val Pro 
         275                280                285
Glu Met Asp Ala Gln Gly Glu Glu Met Lys Glu Glu Phe Glu Thr Tyr 
     290                295                300
Ala Asp Ala Leu Trp Trp Gly Leu Ile Thr Leu Ala Thr Ile Gly Tyr 
 305                310                315                320
Gly Asp Lys Thr Pro Lys Thr Trp Glu Gly Arg Leu Ile Ala Ala Thr 
                 325                330                335
Phe Ser Leu Ile Gly Val Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu 
             340                345                350
Gly Ser Gly Leu Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His 
         355                360                365
Phe Glu Lys Arg Arg Lys Pro Ala Ala Glu Leu Ile Gln Ala Ala Trp 
     370                375                380
Arg Tyr Tyr Ala Thr Asn Pro Asn Arg Leu Asp Leu Val Ala Thr Trp 
 385                390                395                400
Arg Phe Tyr Glu Ser Val Val Ser Phe Pro Phe Phe Arg Lys Glu Gln 
                 405                410                415
Leu Glu Ala Ala Ala Ser Gln Lys Leu Gly Leu Leu Asp Arg Val Arg 
             420                425                430
Leu Ser Asn Pro Arg Gly Ser Asn Thr Lys Gly Lys Leu Phe Thr Pro 
         435                440                445
Leu Asn Val Asp Ala Ile Glu Glu Ser Pro Ser Lys Glu Pro Lys Pro 
     450                455                460
Val Gly Leu Asn Asn Lys Glu Arg Phe Arg Thr Ala Phe Arg Met Lys 
 465                470                475                480
Ala Tyr Ala Phe Trp Gln Ser Ser Glu Asp Ala Gly Thr Gly Asp Pro 
                 485                490                495
Met Thr Glu Asp Arg Gly Tyr Gly Asn Asp Phe Leu Ile Glu Asp Met 
             500                505                510
Ile Pro Thr Leu Lys Ala Ala Ile Arg Ala Val Arg Ile Leu Gln Phe 
         515                520                525
Arg Leu Tyr Lys Lys Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val 
     530                535                540
Lys Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Ser 
 545                550                555                560
Arg Ile Lys Tyr Leu Gln Thr Arg Ile Asp Met Ile Phe Thr Pro Gly 
                 565                570                575
Pro Pro Ser Thr Pro Lys His Lys Lys Ser Gln Lys Gly Ser Ala Phe 
             580                585                590
Thr Tyr Pro Ser Gln Gln Ser Pro Arg Asn Glu Pro Tyr Val Ala Arg 
         595                600                605
Ala Ala Thr Ser Glu Thr Glu Asp Gln Ser Met Met Gly Lys Phe Val 
     610                615                620
Lys Val Glu Arg Gln Val His Asp Met Gly Lys Lys Leu Asp Phe Leu 
 625                630                635                640
Val Asp Met His Met Gln His Met Glu Arg Leu Gln Val His Val Thr 
                 645                650                655
Glu Tyr Tyr Pro Thr Lys Gly Ala Ser Ser Pro Ala Glu Gly Glu Lys 
             660                665                670
Lys Glu Asp Asn Arg Tyr Ser Asp Leu Lys Thr Ile Ile Cys Asn Tyr 
         675                680                685
Ser Glu Ser Gly Pro Pro Asp Pro Pro Tyr Ser Phe His Gln Val Pro 
     690                695                700
Ile Asp Arg Val Gly Pro Tyr Gly Phe Phe Ala His Asp Pro Val Lys 
 705                710                715                720
Leu Thr Arg Gly Gly Pro Ser Ser Thr Lys Ala Gln Ala Asn Leu Pro 
                 725                730                735
Ser Ser Gly Ser Thr Tyr Ala Glu Arg Pro Thr Val Leu Pro Ile Leu 
             740                745                750
Thr Leu Leu Asp Ser Cys Val Ser Tyr His Ser Gln Thr Glu Leu Gln 
         755                760                765
Gly Pro Tyr Ser Asp His Ile Ser Pro Arg Gln Arg Arg Ser Ile Thr 
     770                775                780
Arg Asp Ser Asp Thr Pro Leu Ser Leu Met Ser Val Asn His Glu Glu 
 785                790                795                800
Leu Glu Arg Ser Pro Ser Gly Phe Ser Ile Ser Gln Asp Arg Asp Asp 
                 805                810                815
Tyr Val Phe Gly Pro Ser Gly Gly Ser Ser Trp Met Arg Glu Lys Arg 
             820                825                830
Tyr Leu Ala Glu Gly Glu Thr Asp Thr Asp Thr Asp Pro Phe Thr Pro 
         835                840                845
Ser Gly Ser Met Pro Met Ser Ser Thr Gly Asp Gly Ile Ser Asp Ser 
     850                855                860
Ile Trp Thr Pro Ser Asn Lys Pro Thr 
 865                870



<210> 1210
<211> 2926
<212> DNA
<213> Homo sapiens
<308> NM_004519
<400> 1210

gacccgcgc  ggatgtgac  ccctgaccc  ctgcctggc  tcccctgcc  cccaggggg  60
ccgcctttg  ctgcttttg  gggtgggtg  ggaggggcg  gcggatcat  gcattggag  120
tcccgggct  gcagccgcc  ccgccgcct  gttcacgca  cccgagcgc  ccttcttcc  180
agagcagca  cggagaagg  gaagcggcc  gcgggggcg  ggcagatgg  gctcaaggc  240
cgcagggcg  cgggggcgg  tggcggcgg  ggcgacggg  gcggcggag  cggcggggc  300
gctaaccca  ccggagggg  cgcggcggc  gccggcgac  aggagcgga  agtggggct  360
gcgcccggc  acgtggagc  agtcacctt  gcgctcggg  ccggagccg  caaagacgg  420
accctgctg  tggagggcg  cggccgcga  gaggggcag  ggaggaccc  gcagggcat  480
gggctcctg  ccaagaccc  gctgagccg  ccagtcaag  gaaacaacg  caagtaccg  540
cgcatccaa  ctttgatct  cgacgccct  gagagaccg  ggggctggg  gctgcttta  600
cacgcgttg  tgttcctga  tgtcctggg  tgcttgatt  tggctgtcc  gaccacatt  660
aaggagtat  agactgtct  gggagactg  cttctgtta  tggagacat  tgctatttt  720
atctttgga  ccgagtttg  tttgaggat  tgggctgct  gatgttgct  ccgatacaa  780
ggctggcgg  gccgactga  gtttgccag  aagcccctg  gcatgttgg  catctttgt  840
ctgattgcc  ctgtgccag  ggttgctgt  ggaaaccaa  gcaatgttc  ggccacctc  900
ctgcgaagc  tgcgcttcc  gcagatcct  cgcatgctg  ggatggacc  gagaggtgg  960
acctggaag  ttctgggct  agccatctg  gcccacagc  aagaactca  cacggcctg  1020
tacatcggt  tcctgacac  catcctttc  tcatttctt  tctacctgg  tgagaaaga  1080
gtcccagag  tggatgcac  aggagagga  atgaaagag  agtttgaga  ctatgcaga  1140
gccctgtgg  ggggcctga  cacactggc  accattggc  atggagaca  gacacccaa  1200
acgtgggaa  gccgtctga  tgccgccac  ttttcctta  ttggcgtct  cttttttgc  1260
cttccagcg  gcatcctgg  gtccgggct  gccctcaag  tgcaggagc  acaccgtca  1320
aagcacttt  agaaaagga  gaagccagc  gctgagctc  ttcaggctg  ctggaggta  1380
tatgctacc  accccaaca  gattgacct  gtggcgaca  ggagatttt  tgaatcagt  1440
gtctctttt  ctttcttca  gaaagaaca  ctggaggca  catccagcc  aaagctggg  1500
ctcttggat  gggttcgcc  ttctaatcc  cgtggtagc  atactaaag  aaagctatt  1560
acccctctg  atgtagatg  catagaaga  agtccttct  aagaaccaa  gcctgttgg  1620
ttaaacaat  aagagcgtt  ccgcacggc  ttccgcatg  aagcctacg  tttctggca  1680
agttctgaa  atgccggga  aggtgaccc  atggcggaa  acaggggct  tgggaatga  1740
ttccccatc  aagacatga  ccccaccct  aaggccgcc  tccgagccg  cagaattct  1800
caattccgt  tctataaaa  aaaattcaa  gagactttg  ggccttacg  tgtgaagga  1860
gtgattgag  agtattctg  cgggcatct  gacatgctt  ccaggataa  gtaccttca  1920
acgagaata  atatgattt  cacccctgg  cctccctcc  cgccaaaac  caagaagtc  1980
cagaaaggg  cagcattca  cttcccatc  cagcaatct  ccaggaatg  accatatgt  2040
gccagacca  ccacatcag  aatcgaaga  caaagcatg  tggggaagt  tgtaaaagt  2100
gaaagacag  ttcaggaca  ggggaagaa  ctggacttc  tcgtggata  gcacatgca  2160
cacatggaa  ggttgcagg  gcaggtcac  gagtattac  caaccaagg  cacctcctc  2220
ccagctgaa  cagagaaga  ggaggacaa  aggtattcc  atttgaaaa  catcatctg  2280
aactattct  agacaggcc  cccggaacc  ccctacagc  tccaccagg  gaccattga  2340
aaagtcagc  cctatgggt  ttttgcaca  gaccctgtg  acctgcccc  agggggacc  2400
agttctgga  aggttcagg  aactcctcc  tcctcagca  caacgtatg  ggagaggcc  2460
acggtcctg  ctatcttga  tcttctcga  tcccgagtg  gctgccact  ccaggctga  2520
ctgcagggc  cctactcgg  ccgaatctc  ccccggcag  gacgtagca  cacgcgaga  2580
agtgacaca  ctctgtccc  gatgtcggt  aaccacgag  agctggaga  gtctccaag  2640
ggcttcagc  tctcccagg  cagagatga  tatgtgttc  gccccaatg  ggggtcgag  2700
tggatgagg  agaagcggt  cctcgccga  ggtgagacg  acacagaca  ggacccctt  2760
acgcccagc  gctccatgc  tctgtcgtc  acaggggat  ggatttctg  ttcagtatg  2820
accccttcc  ataagccca  ttaaaagag  tcactggct  acccctcct  gtaatgtag  2880
cagactttg  atagttcac  tactcttac  cccgacgct  accagc  2926



<210> 1211
<211> 872
<212> PRT
<213> Homo sapiens
<308> O43525
<400> 1211

Met Gly Leu Lys Ala Arg Arg Ala Ala Gly Ala Ala Gly Gly Gly Gly 
  1               5                  10                  15
Asp Gly Gly Gly Gly Gly Gly Gly Ala Ala Asn Pro Ala Gly Gly Asp 
             20                  25                  30
Ala Ala Ala Ala Gly Asp Glu Glu Arg Lys Val Gly Leu Ala Pro Gly 
         35                  40                  45
Asp Val Glu Gln Val Thr Leu Ala Leu Gly Ala Gly Ala Asp Lys Asp 
     50                  55                  60
Gly Thr Leu Leu Leu Glu Gly Gly Gly Arg Asp Glu Gly Gln Arg Arg 
 65                  70                  75                  80
Thr Pro Gln Gly Ile Gly Leu Leu Ala Lys Thr Pro Leu Ser Arg Pro 
                 85                  90                  95
Val Lys Arg Asn Asn Ala Lys Tyr Arg Arg Ile Gln Thr Leu Ile Tyr 
             100                105                110
Asp Ala Leu Glu Arg Pro Arg Gly Trp Ala Leu Leu Tyr His Ala Leu 
         115                120                125
Val Phe Leu Ile Val Leu Gly Cys Leu Ile Leu Ala Val Leu Thr Thr 
     130                135                140
Phe Lys Glu Tyr Glu Thr Val Ser Gly Asp Trp Leu Leu Leu Leu Glu 
 145                150                155                160
Thr Phe Ala Ile Phe Ile Phe Gly Ala Glu Phe Ala Leu Arg Ile Trp 
                 165                170                175
Ala Ala Gly Cys Cys Cys Arg Tyr Lys Gly Trp Arg Gly Arg Leu Lys 
             180                185                190
Phe Ala Arg Lys Pro Leu Cys Met Leu Asp Ile Phe Val Leu Ile Ala 
         195                200                205
Ser Val Pro Val Val Ala Val Gly Asn Gln Gly Asn Val Leu Ala Thr 
     210                215                220
Ser Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met Leu Arg Met 
 225                230                235                240
Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Ala Ile Cys Ala 
                 245                250                255
His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile Gly Phe Leu Thr Leu 
             260                265                270
Ile Leu Ser Ser Phe Leu Val Tyr Leu Val Glu Lys Asp Val Pro Glu 
         275                280                285
Val Asp Ala Gln Gly Glu Glu Met Lys Glu Glu Phe Glu Thr Tyr Ala 
     290                295                300
Asp Ala Leu Trp Trp Gly Leu Ile Thr Leu Ala Thr Ile Gly Tyr Gly 
 305                310                315                320
Asp Lys Thr Pro Lys Thr Trp Glu Gly Arg Leu Ile Ala Ala Thr Phe 
                 325                330                335
Ser Leu Ile Gly Val Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly 
             340                345                350
Ser Gly Leu Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe 
         355                360                365
Glu Lys Arg Arg Lys Pro Ala Ala Glu Leu Ile Gln Ala Ala Trp Arg 
     370                375                380
Tyr Tyr Ala Thr Asn Pro Asn Arg Ile Asp Leu Val Ala Thr Trp Arg 
 385                390                395                400
Phe Tyr Glu Ser Val Val Ser Phe Pro Phe Phe Arg Lys Glu Gln Leu 
                 405                410                415
Glu Ala Ala Ser Ser Gln Lys Leu Gly Leu Leu Asp Arg Val Arg Leu 
             420                425                430
Ser Asn Pro Arg Gly Ser Asn Thr Lys Gly Lys Leu Phe Thr Pro Leu 
         435                440                445
Asn Val Asp Ala Ile Glu Glu Ser Pro Ser Lys Glu Pro Lys Pro Val 
     450                455                460
Gly Leu Asn Asn Lys Glu Arg Phe Arg Thr Ala Phe Arg Met Lys Ala 
 465                470                475                480
Tyr Ala Phe Trp Gln Ser Ser Glu Asp Ala Gly Thr Gly Asp Pro Met 
                 485                490                495
Ala Glu Asp Arg Gly Tyr Gly Asn Asp Phe Pro Ile Glu Asp Met Ile 
             500                505                510
Pro Thr Leu Lys Ala Ala Ile Arg Ala Val Arg Ile Leu Gln Phe Arg 
         515                520                525
Leu Tyr Lys Lys Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys 
     530                535                540
Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Ser Arg 
 545                550                555                560
Ile Lys Tyr Leu Gln Thr Arg Ile Asp Met Ile Phe Thr Pro Gly Pro 
                 565                570                575
Pro Ser Thr Pro Lys His Lys Lys Ser Gln Lys Gly Ser Ala Phe Thr 
             580                585                590
Phe Pro Ser Gln Gln Ser Pro Arg Asn Glu Pro Tyr Val Ala Arg Pro 
         595                600                605
Ser Thr Ser Glu Ile Glu Asp Gln Ser Met Met Gly Lys Phe Val Lys 
     610                615                620
Val Glu Arg Gln Val Gln Asp Met Gly Lys Lys Leu Asp Phe Leu Val 
 625                630                635                640
Asp Met His Met Gln His Met Glu Arg Leu Gln Val Gln Val Thr Glu 
                 645                650                655
Tyr Tyr Pro Thr Lys Gly Thr Ser Ser Pro Ala Glu Ala Glu Lys Lys 
             660                665                670
Glu Asp Asn Arg Tyr Ser Asp Leu Lys Thr Ile Ile Cys Asn Tyr Ser 
         675                680                685
Glu Thr Gly Pro Pro Glu Pro Pro Tyr Ser Phe His Gln Val Thr Ile 
     690                695                700
Asp Lys Val Ser Pro Tyr Gly Phe Phe Ala His Asp Pro Val Asn Leu 
 705                710                715                720
Pro Arg Gly Gly Pro Ser Ser Gly Lys Val Gln Ala Thr Pro Pro Ser 
                 725                730                735
Ser Ala Thr Thr Tyr Val Glu Arg Pro Thr Val Leu Pro Ile Leu Thr 
             740                745                750
Leu Leu Asp Ser Arg Val Ser Cys His Ser Gln Ala Asp Leu Gln Gly 
         755                760                765
Pro Tyr Ser Asp Arg Ile Ser Pro Arg Gln Arg Arg Ser Ile Thr Arg 
     770                775                780
Asp Ser Asp Thr Pro Leu Ser Leu Met Ser Val Asn His Glu Glu Leu 
 785                790                795                800
Glu Arg Ser Pro Ser Gly Phe Ser Ile Ser Gln Asp Arg Asp Asp Tyr 
                 805                810                815
Val Phe Gly Pro Asn Gly Gly Ser Ser Trp Met Arg Glu Lys Arg Tyr 
             820                825                830
Leu Ala Glu Gly Glu Thr Asp Thr Asp Thr Asp Pro Phe Thr Pro Ser 
         835                840                845
Gly Ser Met Pro Leu Ser Ser Thr Gly Asp Gly Ile Ser Asp Ser Val 
     850                855                860
Trp Thr Pro Ser Asn Lys Pro Ile 
 865                870



<210> 1212
<211> 663
<212> DNA
<213> Rattus norvegicus
<308> AF091561
<400> 1212

ggtaatctg  cagctctag  catcctctt  accaccacc  ctgtcccga  gatgctgtc  60
ctactcctg  tgggagacc  cttgctcag  ttccctgcc  gcttcctgc  gatgcatct  120
ttccacagc  tctccagct  agaagcctt  atcttggtg  tcatggcct  tgaccgcta  180
gtggctatc  gccgccctc  gcactaccc  gtccacatg  ccccacaga  aaacactgc  240
ctggcagcc  gtgcctgga  caccgccct  ctcctgccc  tcccagcag  ggtacagac  300
tcccacatg  catttgaca  catcgccta  atctaccac  gcttctgtg  ccacctggc  360
gtggtccag  cttcctgct  agacaccag  ccccagacg  tcatgggct  ctgcattgc  420
atggtggtg  ctttcctcc  cctcctcct  gtgctcctc  cctatgtgc  aatcctgat  480
tcagtgctt  agatcaact  caaggaagg  cgttccaaa  ccttctcca  ctgcagctc  540
cacctcctg  tggtgggca  ctactactt  tccattgcc  tatcctatg  ggcctacag  600
gctgacctc  ccgtagact  cctcatcat  gggaacgtg  tctatgcca  tctcacacc  660
gtg  663



<210> 1213
<211> 221
<212> PRT
<213> Rattus norvegicus
<308> AAC64584
<400> 1213

Gly Asn Leu Ser Ala Leu Asp Ile Leu Phe Thr Thr Thr Thr Val Pro 
  1               5                  10                  15
Lys Met Leu Ser Leu Leu Leu Leu Gly Asp Arg Leu Leu Ser Phe Pro 
             20                  25                  30
Ala Cys Phe Leu Gln Met His Leu Phe His Ser Phe Ser Ser Ser Glu 
         35                  40                  45
Ala Phe Ile Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 
     50                  55                  60
Arg Pro Leu His Tyr Pro Val His Met Thr Pro Gln Thr Asn Thr Ala 
 65                  70                  75                  80
Leu Ala Ala Ser Ala Trp Ile Thr Ala Leu Leu Leu Pro Ile Pro Ala 
                 85                  90                  95
Val Val Gln Thr Ser His Met Ala Phe Asp Asn Ile Ala Tyr Ile Tyr 
             100                105                110
His Cys Phe Cys Asp His Leu Ala Val Val Gln Ala Ser Cys Ser Asp 
         115                120                125
Thr Ser Pro Gln Thr Leu Met Gly Phe Cys Ile Ala Met Val Val Ser 
     130                135                140
Phe Leu Pro Leu Leu Leu Val Leu Leu Ser Tyr Val Arg Ile Leu Ile 
 145                150                155                160
Ser Val Leu Gln Ile Asn Ser Lys Glu Gly Arg Ser Lys Ala Phe Ser 
                 165                170                175
Thr Cys Ser Ser His Leu Leu Val Val Gly Thr Tyr Tyr Leu Ser Ile 
             180                185                190
Ala Ile Ser Tyr Val Ala Tyr Arg Ala Asp Leu Pro Val Asp Phe Leu 
         195                200                205
Ile Met Gly Asn Val Val Tyr Ala Ile Leu Thr Pro Val 
     210                215                220



<210> 1214
<211> 31737
<212> DNA
<213> Homo sapiens
<308> AF321237
<400> 1214

ctgagctga  ccaaatccc  gagcctcta  gaactaacc  gatagcacc  tccaccaga  60
ggacggcaa  tcaaaatgt  gcaatgttt  aattacctg  attctcgaa  tttattttt  120
tatcagctg  tttgataat  cactatttt  ctctttaga  gcaattctc  attagtttg  180
tgtgattga  tatatagat  ccttaaacc  atattggct  tgaatctat  atattccaa  240
gaccactgt  ggcactggg  atgaaacaa  ttggcccct  ccctctgga  ttctttagt  300
ttaggaact  ggttttcag  ctgtatccc  agtctttag  atatgcttg  tacacagta  360
ttgctcaaa  aataagatt  attgaatat  caaagtatg  tgggtgccc  aggaaagta  420
tgatacctt  atttagtgg  catgtcttt  agtagaggg  ctatgcgga  caaaaaaca  480
tggggtgta  aaatgcagt  tgttctagt  agttggtat  ggataaggc  ggtaaggtt  540
cctgcagat  gatacggga  ggtggaatt  atctatatt  agtgtgggg  cgtaagtaa  600
catcaagca  agatgtaat  attcataat  atgttttat  tatcagtta  tgaatgagt  660
gatttccct  gaaataaag  taggcactt  tataactgc  aggcactac  gtttttaga  720
attggcagc  tctatcaaa  gtaaagata  gcctaccct  atatattcc  tcttggata  780
agctcgtat  tagcaattc  aatgtttgt  gtttaccct  acaggtata  tggtaacag  840
gaaaaacaa  atatgtata  gaatgttca  aacataatt  tttgtggta  cataaattg  900
ccccaatat  aatgttcat  aataagaga  tagttaact  agttttggt  taactgtag  960
ttaactgta  ttaaactgt  gtgtggaat  taatgaaat  aatagcaag  cataggtat  1020
gctatatat  ttggtcaag  agtgtctcc  agataatag  gattgttgg  aaaattaag  1080
cattaaatc  tatgttaac  acaaaagtg  gcatactca  gtacataca  atatgcata  1140
ttgaattaa  agacatctg  aaagatgta  accaacctg  gatctatgg  tactaatgg  1200
aagggtatt  ggcttgagg  tgtttggaa  gagacttac  attaccata  atttgggcg  1260
tgcatgttg  acacaccac  caacttacc  tttaaagtg  ataattcaa  ggcttttag  1320
atattcaca  agttatgca  ccatcacca  aatcaattt  agaactttt  cgttactcc  1380
aaaagaaac  atacattcc  tagtcatca  catccagtc  tcctataac  ccagcccta  1440
gcaacaacc  atctacttt  tttctctat  gatttgcct  ttcttgaca  ttaatataa  1500
tgaaatcat  caatatgtc  tcctttgtg  ctacttttt  cacttaata  aatgttttt  1560
acgtttatt  atgttgtac  atgttcaat  ctttatatg  atatatcac  gtttttttt  1620
tttgtttgt  tgtttgttt  tttttgagg  ggggtctct  tctctcaca  ggactgaag  1680
gcagtggag  gatctcagc  cactgcaac  tctgcctac  ctgttcaaa  gattcttct  1740
cctcagcct  ccaactatt  gggactata  gcatgtgcc  tgatgccca  ctaattttt  1800
tatttttag  agagacggg  tttcaccac  ttggccagg  tggcctcga  ctcctgacc  1860
taagtgata  acctgcctt  gtctctcaa  gtactggga  tacaggcgt  agccaccac  1920
cccagctga  atatcacct  ttctttata  attcaaaga  atttcactt  ttgtctttg  1980
atcactgca  tttttgagt  ttatgaata  tgttgccat  aacattcat  tataagttt  2040
tgtgtgcaa  atatgcttt  agttctctt  ggtatatac  tactggtgg  gtggctgat  2100
catatggta  cctgctagc  atcctagta  gtgtaaagt  gtatgctat  gtggttttg  2160
tttgcattt  ctttatggc  aatgacatt  aacatattt  catgtgcct  ctggccatt  2220
gcatacctc  tctggaaac  atgtctatt  agattcttt  cccagttat  aattatatt  2280
ttggccttt  tattaccag  ttatgtttc  tatatattc  aaatataag  cccttatca  2340
atacagaat  tgcaaaaat  ttctcccac  ctgtgggtt  tcttttcac  tccttaatg  2400
tgtcttttg  agcacaaac  tttttaatt  tgatgatgt  caatttatt  atttttttc  2460
tttgttctg  aaaatatat  tttgatgta  atttaaaat  caattaagc  aacaaaatg  2520
taaaattaa  taacttatc  tcaaaactg  ggaggaata  agagttcct  ttaaggatt  2580
ggtaagagg  ttttatcct  tcaaagatt  tagagtttg  tggcactgg  ttttatttt  2640
ccattgaat  aacatccac  cctccattt  cctgatata  tggtaatat  gtgtaacca  2700
tacatttat  tgatttgat  tgagactgt  tttgttttg  cagattttc  tagatgtgt  2760
aaagaggag  ataacataa  gaataatct  tattttgag  taaaaaaga  ccttttaag  2820
aattaatct  tacattgta  agtaaaaca  taaggtgaa  ttgttttca  gcttcttcc  2880
ctggtggtt  aaataaaag  ggagaagag  aaagaaatt  ggtcaaact  ttcccagat  2940
ggttgttag  ggtaacttt  gcccaggac  gctacattc  tgtctggag  aaagatgtt  3000
caggagaaa  cccaggaag  gaggaaagg  gtgtagagt  catggctta  cagtagtgg  3060
caaaggtgg  agggttata  attggattt  gtcatacag  tgatgcatg  tggactgag  3120
tgtttgctt  aggccttct  cctgcaaag  gagcaggga  caatgctaa  aatctaaag  3180
accaaacag  taagtagaa  tgcaaaggg  ccttcctcc  aatgccaaa  tccaacttt  3240
gtctgaaga  cagttagga  ttgaaatct  tcatttctt  gactcacag  ccaatccag  3300
tgctgagac  ctgttacta  attatgtag  gtgtaatta  gtctttttt  tttttttaa  3360
aaatctcct  gggattcct  taacccaag  gagttctgc  acttggagt  aaatgttac  3420
tctttattt  tattttccc  taactgaaa  ttgatgttt  cttccaatt  gaatgcaag  3480
aaccaaccc  caccaatat  agaagtatt  atgactttg  cagcagtag  aattataag  3540
atttttata  tgtattgca  ttgttggag  gatctccaa  tatttaaac  catcattat  3600
ttgaaatga  gatggttat  agacccacc  ctacatttc  aaattttag  gtattaata  3660
agaagcaca  atattgctg  ttacaaatc  gttttctaa  attatttcg  taactgtat  3720
ttgatataa  tggtttcct  agtaatcct  tacatttta  ttgatgtat  taaaacgtt  3780
ttctgagat  ctttcacca  acagttaaa  gattgatag  ccaacccgt  tataggatc  3840
taaacttta  actttaaag  aaatttatt  cccttcttt  tggaacagc  ccacaaaat  3900
ggattatta  ttcaaatct  tctagggat  ttggcaaaa  ttctaaatg  ctctgctta  3960
ctatgtgat  aaattatta  ttgtttaat  aattatggt  atttatgaa  tgaagttct  4020
tgctatgtc  tgtaaagga  acagaggtg  aaaagacat  gaaactatt  tcaaaggaa  4080
ttttacttt  gcgggggga  tggacagat  atgcatata  tttttagca  agagagctg  4140
ggagtagtg  tgtttgggc  gagtatgaa  ctagtcacg  tggtggctt  aaatgaaaa  4200
tctgttttg  tggtgtgtc  gttatgttg  aagttcatt  acagttgag  ctgaacaga  4260
ctcaagctg  ggcttcaga  aggattccc  agggtatcc  gagttaatc  ttggtttcc  4320
agctcctgt  agacaggtt  gtttcttaa  taaaacata  cagtacttt  gctctttct  4380
atttcttat  ccttcgtgt  tgtcctttc  cggaaaata  aacagaaaa  tatattatc  4440
taagcgggg  agaggagat  tgacaagag  acttacgac  caggggttt  agttaagaa  4500
aaacagaaa  taaatggca  gactttata  atgaactca  tctgtattt  atattgtat  4560
attaaaagt  tggtattca  agtgagaaa  ataatttta  aaatctatt  ttgccagat  4620
acaccaaca  tgaatgcaa  atcttttaa  gtttgtttt  caacactga  aatgttcca  4680
tgaaagaaa  atgatcatc  tatgaaggg  gttcttgaa  ttttcagta  aaattgggg  4740
agttcctaa  cctgcactt  tgaattata  aattttata  gtatgcctg  ctatggtta  4800
cacatagtg  cttcttact  aaaaggaca  caaactatg  gacagataa  tcagacaca  4860
gtgacagaa  tcctccttc  gggactctc  gatgggcca  acaccgagc  gctgctatt  4920
atcgtatta  tgggtgtct  cctggtcac  gtgcttgga  atctgcttc  aatctccct  4980
gttcatgtt  actcccaac  tcacacacc  atgtatttt  ttctctgca  cttgtctct  5040
gctgacctc  gtttctcta  caacatagt  cctcaggca  tagtccacc  gctttccag  5100
aagaaggtc  ttgcattca  actttgcgc  gctcgactt  tctttttcc  catttttgg  5160
tgtacccag  gcgcccttc  tgcagtgat  tcctatgat  gctatgttg  aatctgcaa  5220
cctctgcgt  accctaaca  catgacctg  aaagtgtgt  tccagctgg  aacaggatc  5280
tggaccagt  gcattctgg  gtctgtggt  gacaccacc  tcacactga  gctacccta  5340
cgaggcagt  acagcattg  tcatttctt  tgtgaggcc  ctgcactat  gatcttagc  5400
tccacagac  cccatgcat  agagatggc  atttttctt  cgggggttg  gattctcct  5460
atacctgtt  ttctgattc  ggtatccta  ggccgtatc  tagtaactg  ggtcaagat  5520
aagtcaact  tggggagtc  caaggcatt  tctacctgt  gctcccacc  catggtggt  5580
atacttttt  atggatcag  aattatcac  tacatgaca  ccaagtctt  caaacagca  5640
gaaaaatcg  tgtctgttt  ctatgcaat  gtgactccc  tgcttaatc  cctcatcta  5700
agcctgaga  acaaggatg  gaaggcagc  ctgaggaaa  tagccacaa  gaatttccc  5760
tgaaggctt  gaatctcac  ctgacagtg  gctcagaga  ccttttggc  tcctacttc  5820
aagacttgc  gggaagaca  ggaatcaac  caggtggat  ggattttta  aaatgtaca  5880
tggcacact  ggtttctca  gtcacctgc  tggccccct  ccaagttgt  ctttccttc  5940
ttttcctcc  ttccttttc  ttccttact  ttctaaagc  ttttaataa  ctttctcct  6000
ctttgaaaa  aaaagtaca  atacaccat  gaatactat  cagccacag  atagaatga  6060
atcatgtca  tcgcagaaa  atagatgca  cttgaaacc  ttatcctaa  tgaactagc  6120
caaaaacag  aaaccaaat  cttcatgtt  tcactcata  gtaggaact  aacattggg  6180
acatatgaa  acaaaggtg  gaacaatag  cattgggga  tactagatt  tgggaggga  6240
ggggaaggg  taaaaaaac  acctattac  tactcacta  ctgggtgat  gattcattt  6300
tactccgta  ctcagcatc  catgatata  ctctgtaac  aacctgcgt  tgtaccctc  6360
attttaaaa  aaaagttga  aagaagaaa  aatgcacat  agatttcaa  ttttcacac  6420
tatatgaaa  tagaattta  atcatgtca  tagtaattt  atatggatg  catgacaat  6480
aaataatat  ttaatatat  ggataaaat  aacttatat  attaaagaa  acttgctgg  6540
tagccctct  ctttgtgaa  ctaaaatat  gtaagactt  aagtgatgg  tatggtaat  6600
accctgatt  gattattat  caatgtttc  atgcattga  acatcacac  gtattccca  6660
actatatat  attatgtca  ttgtaaatt  aaaattaat  aaaaatatg  taagattct  6720
attcttggg  cttatccat  gacacaccc  ctatccttc  tcctgcatt  ctttcatag  6780
aggagaagg  caataattc  tggagcaat  ggaaggagg  tatgcttcc  tctggttgg  6840
cctttgaca  ctaagggtt  agaaatccc  cgagaaaca  acatatttt  taagccttg  6900
aaaatctac  tttttaata  tgctgtgta  tatcacctg  ctatttcag  tcttacttc  6960
agtcctttt  cttttggta  ttctgaatc  ctctgcatc  tcaaatgat  aataaatag  7020
cattactga  tcacttact  tgagctagg  gctacatgt  tgttggcat  tgcacctgt  7080
tgtgtgctt  acatgggta  tgaagagca  gggtacaat  aagcagaat  tatgagctc  7140
gctctcctt  tcacactct  ttagaaaca  aaggatcat  tttatcagg  tacatcttc  7200
taaagatga  tataggagt  gtggaaacc  gcaagaaat  gtgacacat  ccaagaata  7260
tgacacata  caagagtga  aagctgtaa  taacgataa  cctgaatga  caagaggag  7320
gaactagaa  ctggagagg  tagaaatat  ctaagggca  aaggcagta  ctgtggact  7380
aggctatgt  aaggcaagg  agccatggg  agaaatatt  ctcaagccc  ttttccacc  7440
gccttctga  cccccacta  tgtattcca  ttagaagcc  gggaacaag  agccttttg  7500
tataatcca  aaaagatgt  aaacattct  aagcacata  caagctgaa  aaggataga  7560
ggtagatct  gaaaggtca  ctggtgaag  acacacctt  tgccctcag  atccacttc  7620
ttcagtgat  aattcatat  tctaataca  ggaacacat  aagttccat  aagaactat  7680
tcatagcgg  atgatatca  gtagctcac  cttctactt  ctacataaa  gaatagctc  7740
tgtcatgat  atttatgta  gttgaaaga  gaagagcaa  aaaggcaaa  aattagcag  7800
aaacatagc  attgtagct  ctaatcctg  cccagacat  agttgataa  tatagcttg  7860
tctttcact  ccctttcat  gatttctta  tttctacct  aaactcagc  cactggagt  7920
ttttaacaa  gtgtggcaa  ctaaaactt  ttacctgta  tatttgagt  attgatgat  7980
ctgttcctt  ttttttaac  tttagtttc  cgggtacat  tgcaggttt  ttatatagg  8040
caattgcgt  tcacaaggg  ttggtgtac  gattacttc  tcacccagg  aataagcat  8100
gtacctgat  ggcagttta  tttatattc  cccttctct  accctcaac  ctccagtag  8160
ccacaatat  tgttgttct  ttatttgta  ccatgtgta  tcaatattt  gctccaact  8220
ataagtgag  acacacagt  tttggtttt  tgttcctgt  ttaagatag  ataatagcc  8280
ctagctcca  ttatgttgc  gcaaaagac  tgatctcgg  ctttttcat  gctgtatag  8340
attccatgg  gtatatgta  cacatttcc  gctattgat  ggcatttag  ttgattcca  8400
gcctttgct  tgtgaatag  gctgcgatg  acataaccg  gcacgtgtc  ttatggtag  8460
gtaatttat  ttcctctgg  tatataccc  gtaatggca  tgttgggtc  aatagtagt  8520
ctgttttaa  ttattcaag  aatcaccaa  ctgctttcc  cagtggctg  actaattta  8580
attcccacc  gaaaagtgt  cccttttct  tacaatttt  ccagcatct  ttttgttgt  8640
gttgttttg  ctttttaat  gtagccatt  tgactggtg  gagatggta  ctcattgtg  8700
ttttgattt  cacttctct  atgattagt  atgttgagc  ttttttcat  tgcttattt  8760
ccacttgta  gtcttcttt  gaaaagtgt  tgttcggca  cctatagaa  gggagaaaa  8820
ttttgcaat  tatccatct  acaaaggtt  aatatccag  atctacaag  tccttaaac  8880
aattttcaa  aaaaagcaa  caagcccat  aaaaagtgg  tgaaggata  gaacagaca  8940
ttctcaaaa  aagacattg  tgtggccaa  aaacatatg  aaaaaaaaa  ctcatcatc  9000
ctggtcgtt  gagaaatgc  aatcaaaac  ataatgaga  accatctca  accagtgat  9060
atggtgatt  ttaaaaagt  aggaaacaa  agatgctgt  gtgactgtg  agaaatagg  9120
atgcttttt  gtgggagtg  aaattcact  attcaacca  tgtgttcaa  cattgtgga  9180
gacagtgtg  caattcctc  aggatctag  accagaaat  ccatttgac  cagaaatac  9240
attactagg  atatactca  aggattata  atcattcta  tataaagat  catgcccac  9300
tacgtttat  gcagcactg  tcacaatag  aaagacttg  aaccaaccc  aatgcccat  9360
agtgataga  tggattaag  aaatgtggc  catatacac  atagaatac  atgcagcca  9420
gaaaaagga  gagttcatg  cctttgcag  gacatggat  aagctggaa  ccatcattc  9480
cagcaaact  tcacaggaa  aaaaaacta  acaccgcct  ttctcactc  taagtggga  9540
ttgaacaat  aggacacat  gacacaggg  ggggaacat  acccaccgg  gcctgtcgg  9600
ggatggagg  ctaggggaa  gatagcatt  ggagaaata  ctaatgtag  tgactggtt  9660
atggccaca  caaaccacc  tggcacgtg  atacctatg  aacaaacct  cacgttctg  9720
acatgtatc  cagaactta  tatgtgtgt  tgtgtgtgt  tgtgtgtgt  tgtgtgtgt  9780
tgtgtgtgt  tatagatgt  gtgggatat  gaaatctcc  actattgtt  tgttgtttt  9840
tatttctct  ttataattg  catatcttc  tggtaaatt  actttttta  cattaaata  9900
tgttgtttc  ggtaaaaaa  aatttggat  ctaagtaaa  ttttaaata  atttactta  9960
attactact  tttttatgg  ctccatttc  ttaaatacc  gattttcct  tggtatctt  10020
tttttttta  gagagagag  atctccctc  gttgcccag  ctggagtgc  atggtgtga  10080
cttgtctca  tgcaacctc  gccttccag  ttcaagcaa  tcttctgcc  cagcctccg  10140
agtagctgg  attacaagc  tacgccacc  tgcccagct  atttttgta  ttttagtag  10200
gatggggtt  cgccatgtt  gacaggctg  tcttgaact  ctgacctca  atgagtcgc  10260
tgccttagc  tcccaaagt  ctgggattt  gaggcgtga  ccaccacac  tggcccgtg  10320
atcattttt  tttctgcca  caggacatt  tttaatatt  ctcatggtg  gggttctgc  10380
ggtgataaa  ctttgaggt  ttgtatgcc  gaagacatc  ttatttccc  ttctttctg  10440
aagatattt  tccaagtgt  gaatttcag  ttgaaaaat  gttattctc  tgaatacca  10500
aaaagtctt  cttcatttt  acttacctg  attgttttt  atgagaaat  tgatgttat  10560
cttatcttt  tacctctat  catagaatg  ctcgcctcc  tcccactgg  cacttttga  10620
attttctct  tatcattgt  ttttgagca  tttgataat  acatacctt  agttatgtg  10680
cttcatttt  ttgtgctta  catttactg  gtttcttga  ctgtggttt  tagttttaa  10740
taagtttgg  aaattttca  ccattattt  ttcaatttt  ttttctgtc  tctcctctg  10800
cttggtgac  acaactacc  tcatgttac  cagtgtgaa  ctgtcccat  gttcactga  10860
tttcttctc  tattttgta  tcatttttc  gttttattt  gcattttct  tggctattc  10920
tcaaactca  taatctttc  tctgtaata  ttaacctgc  gtgaatccc  ttcagcata  10980
tttttatct  agatatttt  gttttcatc  ctagaagtt  aatttgtct  ttatttata  11040
ctttcatgt  tctacttaa  tttttaaac  tatgcaata  cataacttt  aatattttt  11100
tctgttaat  gtaacattt  agtcagttc  gggttgatt  atactgatt  ttctcctca  11160
tatataagt  gttatttcc  tgcctcttt  cataactca  aatatttta  tgaatgcca  11220
acttggtga  ttgtactcc  gtggattct  ggtattttt  gtattccta  aaatcttct  11280
gagctctgt  ttagaattc  gttaattca  ttggagata  ttttgtcct  ttgtgtttt  11340
ctgtatgaa  tgttaggtg  gtctgaagc  gtgctcagt  tagggacaa  tattcccca  11400
tactgaaac  ggaccttcc  gtatcttct  cccactatt  catgaatta  gagtttttc  11460
agcctgaat  ttgggaaca  gaactacta  ggacgctgt  ttcatgcca  gcacctctg  11520
tgcttcctt  gattctttc  gatggctat  tccccagcc  tggacagtt  cttcagatg  11580
atatgcttg  ctctattga  caggcaaaa  ggaaccctt  tagatcttt  gggttctct  11640
tctctgcag  tctctcttc  ctgttatac  ttcataagg  ttacctcat  tgtttccag  11700
ctctcagca  ctactttcc  ttgttgctt  atgcctgtg  cttgaagga  cattgtttc  11760
tgtatttta  gtgtttctt  ttttattgt  ttaggtgag  ggtaaatcc  attcctgtt  11820
ttcaatttt  gctaaaagt  gaagtcctt  agagtagtt  tgaatgaca  ttttgttca  11880
tacaaaaat  tatacagcc  gtattttct  tcagcagtt  aaaagtatt  tcccactgt  11940
ttctgtctt  cactgattt  gtgattgta  agatgcttt  tacatattc  ctatatctt  12000
ctcagcatt  tgatgtgat  atttatttg  ttgttttag  tatccgatc  gtgttcact  12060
agctagtat  tttttcaga  attgcatct  ttttacttt  ttgttttct  ctggaaatc  12120
gactatcca  gatttagac  tttttgctt  gttgaactt  tatgctcat  tctttattt  12180
ccctccttt  tgttctgtg  ttctgtctc  atactttct  ctgaacaag  ctacagttt  12240
taaattatc  cttctgctt  gtggacttt  ctattgagc  tacctaatg  attttcagt  12300
cagtttatt  tttagtttt  tgtctgttt  tctttttat  aattgtagt  atctcatga  12360
aaaatcttt  tctctcttt  cttaaaaat  ttagtaata  ttattttga  cttagaact  12420
taatatcta  atcacctct  aatctttta  gaataatgg  aatatatct  aacatagac  12480
aataaatta  ccataaaag  ttggcaaac  aatgtcaca  atgtcacaa  tatttatag  12540
taaatttcc  attttttct  tcggttttc  gtcattttt  acccttttt  attagcatg  12600
tttataatt  tttcattaa  tagtccccc  gtagaggct  tggatgatt  ttttctttc  12660
aagaggatg  agttttctt  tgacagggt  aaaacataa  cagatcaat  caatcctat  12720
gatggttgg  tttaggctt  tttaggctt  ttctatcta  ttttgcatt  gttcctaaa  12780
tattacctt  gtgggatct  agctgaaag  acagagtga  ctacctcac  agacttaaa  12840
cctaccctc  atctcccag  accaatcgg  tagtaaatg  tcagctcat  tatatatat  12900
tttttagcc  ttcatatgc  gctttcttt  gagtttcct  gagtctttt  ttgtgcata  12960
accgtttag  agtgacaaa  aacttataa  tatattgca  gcaaatttt  ggacttgtt  13020
atctgtggt  ccctcatct  tgtgatttg  ttctcaatg  taatatgtt  ggcaacccc  13080
aattctaat  tctaccctc  tatttcagt  actgctact  tatgctaac  ctctctttt  13140
ctcttagag  aatgacaaa  gcccttggg  aaaacactt  ggtgaatgt  gcacttacc  13200
tattgttct  ccctcctct  accttttct  ttcaagtcc  gcatttgct  ctctcctgt  13260
tctctaagc  cttgttttg  gtgttttgt  aatctttta  agttgtgta  ttgttttgg  13320
gagaattat  taaattcaa  ctacttctc  gtggccaaa  gagaagtgc  gacattaag  13380
gtgtcttta  agttatcca  gtgattctg  tccacagtt  aaaatcatt  tactatatc  13440
atgtaattg  gaggccagg  gattttaag  gaggctgga  aggtggata  agactagca  13500
aagttggga  tgtagaatt  gtaaaggtt  tgcatttta  tttaatagt  atgggaagc  13560
gtgaaaagt  ttcaagcaa  ggaatgaca  aatcttgtt  acatattga  aagactact  13620
aggatcctc  acggatagt  gattatagg  aagcaagat  gaaatagga  gatatgtta  13680
gaagtactg  agtagtcaa  gtaaagaac  attgtgtct  ggtctagga  aatagcagc  13740
tagatcaaa  aaaattgga  atagcatat  ttttggaaa  catttgtca  gtttgctga  13800
aggttcaat  tgagggatg  aaggtagtg  gtaaataag  atggctctt  aggttttgg  13860
ttgagtcac  gaataaatg  tgataatat  tgctggtga  tagaagagg  gaataaaaa  13920
gcaagtttt  tggaagtgt  ttggatgaa  taagtttga  ctgcctact  gacataaat  13980
cagagggat  aagaataca  ttggatatt  gatttgagc  caggggaga  atcacattt  14040
aagataaaa  tttggggat  agtactctg  acatagtat  taaaggcat  aaaccagat  14100
aaatctttt  gatgatctc  aacatggga  taataataa  aatagttat  tcaaagggc  14160
gttttaaag  taaaagtag  attttataa  tgtaactta  aaactatag  aatgtatat  14220
ttttgttat  ttttctaat  caaccctat  atgtaattt  catagaaat  attaactgc  14280
ggcagggag  agatagaaa  gttatgtat  ttacacatt  tcttggata  tacagacac  14340
cttcagatg  acagatata  agtttttat  atttttaat  cccacattt  atcataaat  14400
tagaattgt  ttaaatatt  gaaacctaa  atattgata  gtcagcatt  ctctgcagg  14460
attatatat  gatatctgt  agggatcct  gatagttga  tgtttggac  tatttagca  14520
ttccaattt  tttcatggg  aatcaaatg  atattaatt  catttttcc  atgctcaag  14580
cactgtgct  ggccatgta  gagatataa  tatgttata  accctgtcc  tacaagaaa  14640
cagtataat  aaggagcaa  gaagtagga  agaataaaa  tagatcata  gtttgtgtg  14700
atgtgtttt  agagaagaa  atactgtca  gttggaagc  attgaaccc  cgccatgaa  14760
gaggtaata  ctgaaatac  tcttgaagg  tggtcagtt  atgaatata  cacaatatt  14820
tgaatgagc  gaatagtaa  aaaattttt  aataggcaa  aaaaagttt  aggaagaag  14880
aaacttaac  cttctttgt  aacagtatt  ctaaattat  atccagaaa  agaatcata  14940
agtccttgt  gaatttagt  aagattatg  gtaatgtag  attgtggca  aaagtaact  15000
acaacgtgc  gattaggtg  ggacttttt  ttggacttt  tggtatgaa  gatgagcct  15060
atttgatta  cagatttct  attttgttg  ctaggtagt  ctagtgaca  tctttgaaa  15120
aggaattca  ttcaagaag  aggatttga  aaagaaaat  agttaagtt  ttgacatga  15180
ttaaaagat  cctttgagg  gccttttgg  aatcaatgt  gatatgtct  atggacact  15240
gcaaatatc  gactctcaa  cttagagtg  tgaggtttc  ctctctctt  ctctctctc  15300
ttctctcac  ttgttcatg  gtgtatggt  tgggtatat  actttgtac  aactcatca  15360
attgtatac  ttaaatata  gcagtttct  tatattact  atacttcaa  atagctatt  15420
tttaaaaaa  caacagagt  aaaaaaagc  ccaaggtta  tattggaac  ttggggaac  15480
tagtgtttc  aatggttaa  tgtttgtga  aaaactcct  gaagattga  aacgagtgt  15540
cagagatgc  gaaagaaaa  cagaacaga  tggtatttg  gaaataaca  gtgtagaaa  15600
tttcaaaag  aatacatga  caatgtaag  gttgtaata  agtagcaaa  tcaagatta  15660
acactggac  ggttaatat  gaggccatt  atgattttg  aagatctat  gcaatgaag  15720
gatagggga  gaaactaga  ttcagtgaa  aaatagtaa  tttaatgaa  ataaaatag  15780
aattataaa  tttttttcc  caagaagtt  tctgatgct  atgggtgtg  gttttcttt  15840
aggggtgat  aaactgtaa  attagattg  ggtgatggt  gcacaacat  gtgaatatg  15900
taaaaaaat  gaattataa  ctttaaatg  gtgagttgt  taatatgta  gttatttca  15960
taaagatgg  acaaaagta  tccaagcgt  aatgagaaa  ataagagaa  cgtgatcaa  16020
attgtaatt  gtttttgtt  taaggatca  ggcctgttt  cagcttgag  caaaagagg  16080
gaagagatt  aagttacag  tgaaacaga  gagatactc  aagaagcat  gttcataga  16140
aagaggcta  gcaatcaag  atttctcag  ttaagagaa  taggcatag  tgtgggcat  16200
gatggaaac  tttttagat  taagggcat  agtaaaagt  atttaaatc  gatcacccc  16260
attttcttg  tgaagtgga  gttgttttc  tgaataaaa  aaggaagag  ggtacaggg  16320
aaagtagca  aaacttgga  attagctga  aagaataaa  taagaccaa  tgcattaat  16380
tcgtattgc  gctgtaaca  attaccaca  acctagtag  ttaaaacaa  ctagatttg  16440
tatctgaga  ttctagagt  caaaagacc  aaatcagtt  cactgtgct  aaattaagg  16500
gtcagctag  cctacatta  tttctgaag  ctctagggg  aaattttgt  cccttgact  16560
tttcagctt  cacaggctg  ctacattcc  ggatcatgg  cctgtcttc  aatttcaaa  16620
tcagtggca  atcaccttc  gtcttctct  acctctgcc  atgcttaca  ctttctgtc  16680
ctccttctg  tcatcttgc  tccctctta  aaggatgtt  gtgattaga  tgggtccat  16740
cagatagca  aagataatc  ccctatata  gaatcctta  gtcaatcac  tctgcagcc  16800
ttttaccat  gaaggtacc  ccttcacag  ttccaggga  tagaatata  atatcttcg  16860
ggggggggc  actatttac  ttacccacc  aggtcaaga  aaaggaatg  gaacaagtg  16920
ttaaaattt  actgaaatt  gagactacc  atatttaat  gtgacaatc  gtttaactg  16980
gtgattgcc  tcatgcaaa  agaacccca  gatctgcct  ttcttttga  aattcttat  17040
gtcatttta  agaatgagc  atctttctg  agcccttgt  tcacgagag  tgaaggaca  17100
tttgtgcag  aaaggaaac  ggtcctggt  cttctatgg  acacagaga  agggttgtt  17160
acagagttg  tgaggtgga  atgcctgtg  agtaaaata  ttttgccct  taattatca  17220
tgaattgcc  ggagtaagt  tacacacag  tatgttgcc  atacacaac  ttgctgttt  17280
ctgagtcca  agttggact  tgttcacta  ataaaatca  aaagagagg  tactgtgtg  17340
ttgaaagat  cacaagctt  aaaaagaca  ttgattcca  ccaatcaca  taagattac  17400
gaaaaaaat  tcgtaagca  agaatcttt  ggttcttta  accagttcc  cataatttc  17460
ccacttata  ttgactggg  gttctttat  cctttgcta  caagcagtt  tcatacacc  17520
ggtgaataa  gtgagattt  gacagttgt  gttgtggag  agcctttct  cagataagg  17580
acagactga  tggtagcag  gacagaact  ttcagtcgc  agtcctcta  acacgtata  17640
tttataaac  actggagga  tgaagtatc  ttttattat  tgttttatc  ctagaatgt  17700
tattctatg  ggtaagaaa  ttatctgtt  tattcacca  ggtgtcttc  gggcctaaa  17760
gaatctgaa  catgctgag  gctgaataa  aatttgtta  aattttgag  tcaaactca  17820
atttgttga  aaacatgag  aaaagaata  aacaaaact  tacaattta  tagcattat  17880
atttttatt  taattactt  gtaaacaaa  acagcctag  aatatgcag  taggttttg  17940
acaaataga  gaaattaaa  cagaaaatt  taaaatgaa  tggatgtgg  agttcaaga  18000
agattaaaa  aaattttaa  acatggtgg  ttatagtta  cgatcttct  aggatccta  18060
tttatataa  ctagcagca  ctccagaga  attggtacc  ccatcccat  gatactatg  18120
gatactata  tgctttctt  cattactca  gttctttct  ttatacata  atatatata  18180
tttattata  ttcaagttc  agggtacat  tgcacaacg  gcaggtttg  tacgtatgt  18240
tacatgtgc  tagttggtg  gctgcaccc  ttaactcgt  atttacatt  ggtatatct  18300
ctaatgcta  ccctctccc  tccccccac  ccacaacag  ccccagtgt  tgatgttcc  18360
cttcctgtg  ccatgtgtt  tcattgttc  attcccacc  ctgagtgag  acaagcggt  18420
tttggtttt  tgtccttgt  atagtttgc  gagaatgat  gtttccagc  tcatccatg  18480
ccctgcaaa  gacatgaac  catcatttt  tatggctgc  tagtattcc  tggtgtata  18540
gtgccacat  ttcttaatc  agtctatca  tgttggaca  ttgggttgg  tccaagtct  18600
gctattgtg  atagtgctg  aataaatgt  cgtgtgcat  tgtctttac  gcagcatga  18660
ttataatcc  ttggtatta  tataatcct  tgggtatat  cccagtaat  ggatggctg  18720
gtcaaatgg  atttctggt  ctagatccc  gaggacttg  cacactgac  tccacaatg  18780
ttgaactag  tttcagtcc  accaacagt  taaaagtgt  cctgtttct  cacaccctc  18840
ccagcacct  ttgtttcct  actttttaa  gatcaccat  ctaactggt  tgagatggt  18900
tctcattgt  gttttgatt  gcgtttctc  gatggccag  gatgatgag  attttttca  18960
gtgtctgtt  gctgcataa  tgtcttctt  tgagaagtg  ctgttcata  ccttcgccc  19020
cttgttgat  gggttgttt  tttttttct  gtaaatttt  ttgagttct  tgtggattc  19080
ggatattag  cctttgtca  atgagtaga  tgcaaaaat  ttctttcat  ctgtaggtt  19140
cctgttcac  ctgatggta  tttctttag  tgtgcagaa  ctctttagt  taattagat  19200
ccatttgtc  attttggct  ttgttgcca  tgcttttgg  gttttagac  tgaagtcct  19260
gcccatgcc  atgtcctga  tggtattgc  taggttttc  tctagggtt  ttatggttt  19320
aggtctaac  tgtaagtct  taatccatc  tgaattaat  tttgtgtaa  gtataagga  19380
gggatccag  ttcagcttt  tacatatgg  tagccagat  tcccagcac  atttattaa  19440
tagggaatc  tttccccat  tcttgtttt  gtcaggttt  tgaaagatc  tatggttgt  19500
gatgtgtgg  attatttct  agggctctg  tgtgttcca  tggtctata  gtctgtttt  19560
gtaccagta  catgctgtt  tggttactg  agccttgta  tatagtttg  agtcaggta  19620
cacattact  atgttcttt  tttcagaaa  aggtcttag  agaaagtaa  aaatttcag  19680
aggcatacc  tgtcacctg  aaagagtag  aacacaaaa  ccacttgag  aattcattt  19740
tctattttt  gtgtgtgta  ttacatttt  ccccttcag  ttccatcta  gccaatcat  19800
gtttctgag  gcccagggt  ctgtggata  gccgcttca  tgcagcctt  acttcttta  19860
tccttgagc  gtagatgat  gggttcaac  tgggagtca  cactgtgga  gagagtgac  19920
gcagcttct  gctctcaga  gaggcactg  attggggtc  gaaatacgt  aggatggca  19980
tgctataga  gagagagac  accaagagg  gggcggaac  ggtggagaa  gcctgatgt  20040
tcccctcag  tgacggcat  ctgaagata  tggagagga  gcggacata  gatcccagg  20100
tcagcaaga  aggaaagag  atgaatggg  cagtggctg  cagagcctc  agttcaaac  20160
cagaggtgt  agcacagac  agtgcaata  caggagggc  gtcacagaa  aagtggttc  20220
ccctgttgg  gccacaaaa  gggaaactg  aaatccatg  ggtttgcac  gtggccact  20280
aaaaccctg  gaaccaaga  gcagctgcc  gctgggcac  ggatatgtg  cccatgatg  20340
ctgggtagt  caaggggtc  cagatggcc  cgtagcggt  atatgccat  gtggccagg  20400
ggcagcact  agcagcccc  aaaaagaag  agaaataca  ctgagtggc  catccaagg  20460
aggagatgg  tgtgtcttg  atgatcagg  tccccagca  cttgggcac  atgaccaag  20520
tgaaaccta  ctccaggaa  gacaagttt  tgaggaaga  gtacatagg  ctttgtagt  20580
cagagtcag  tatagtgac  aggatgatg  ggacattgc  cattaaagt  accaagtaa  20640
tggtcaaga  aaggagaaa  agtagagcc  gaagctcag  ggacagggc  gagaagctc  20700
cgagaacaa  ttcactgac  attgtccag  tttcccaca  cattcttct  cccaggact  20760
cactgggca  tcaaaatct  ggaaggtag  agaaatctc  tatgttatt  ataccttta  20820
tatattctt  taaagggga  ctcctgtgg  ctcattctt  actttcctt  ttagagttg  20880
tgaggatca  acatctata  tctccaaaa  ataataaaa  aaatttgac  attagattc  20940
caatttttg  ggaaagaat  ctacttttc  agacttaat  aacatacta  atatatcta  21000
acatgtcct  atttttctg  tctctgtag  gaatgggca  aatcacagc  ttatgttca  21060
gctcctacc  tatctctct  caataatgg  gctaagaaa  gcaggccaa  catttatga  21120
gagagaggt  gtgacacat  atgaaaagt  gtgaggtca  gcaggtata  tttttgcaa  21180
acaaaaatg  aggaaggag  aaatcaaag  aactgattc  gcaattact  aatgattcc  21240
gaggaggag  tccgaatgt  tctcaatct  aagaagccc  tactcagga  ggtttcact  21300
tattgtgag  atctcaatt  ctacactct  aaaattgca  tgtaaacaa  aagacacac  21360
acatagtca  tgtggctta  cttgatccc  gggatgagt  ttttccaag  ggttgtatg  21420
gtcaagata  catcagaac  atggacaga  tctagatgg  ttaagcatg  actttttca  21480
cagctctct  ggttgactt  tgtcttgac  ctcaagaaa  ttgaagctc  cattttaca  21540
gttaataaa  tacaactta  atatgcaag  gtgactaat  tgaaatccc  tgaaaagga  21600
acaaaagat  tcatcattg  attaataac  aagcttcaa  attgggacc  tgaaattct  21660
tgtgatgac  ataaacata  ggaggaata  aatctgaag  acttagcat  ttgtctgct  21720
tactgtaca  gttccatga  tgttaacca  tataattat  gatataatg  tagacctat  21780
ttctaaatc  tcttatcca  ctcattgcc  aaactcact  tagccccta  tattcaatc  21840
ctaaaataa  ataattaat  cagtaaata  tgattatca  aagataatt  tgtatgcta  21900
gctctgttt  agatactga  gataataca  tagtaaata  aacaagcaa  aatctctgc  21960
ctcataaaa  tcatcatag  gaagacagg  tataaacaa  ttctgttaa  ccaggcacg  22020
aggctcacg  ctgtaatca  agctctttg  gaggtggag  ctggctgat  acctgagat  22080
gggagttca  gaccagcct  accaacata  agaaaccct  tctctacta  aaatacaaa  22140
ttagctcgg  gtggtggtg  atgcctgta  tcccagcta  tcaggaggc  gaggcagga  22200
aatcgctgg  acacgggag  cggaagttg  ggtgagccg  gatcacacc  ttgcactcc  22260
gcatgggca  caagagcaa  attccactc  aaaattaat  aattaatta  ttatgttag  22320
agaaagtat  gtatataag  gcaatggag  agaataaag  agtagagaa  gagacaaac  22380
tttagaggt  gaaagtgtc  gggaaagct  cactgagaa  atgatattt  agtaaagtt  22440
tgagcaggt  caagaagtg  atttaggtt  gtgaaggaa  gagggcggt  aagagaaaa  22500
aatgagaaa  tgctatttt  atttttttg  tgattcata  tcatttaaa  caattcaac  22560
aaggaatca  ttctcttat  aaaacatcc  tgatacctc  tctactttc  tagtaagaa  22620
gagcattta  gaagcagca  ataagcacc  cacaccgtt  taagtgttt  gcatgtatt  22680
tcttatttg  ttctcacaa  acctgaaga  acagatagt  ttataccca  tttacagtc  22740
aggaatctg  gacacagat  agttgagta  ttttttcag  aagtgttgg  atcctgggt  22800
gctgagtcc  agtcaggga  ttggccgac  agtgacact  gcactcact  tttcagaat  22860
ggaataaat  tgagccaca  gtgaggaca  gccagtatc  agtacaggg  ggtagtaag  22920
acaaagcaa  acaatttct  aagatgggc  gaaaatttc  atatattag  aacattgga  22980
aactggaat  ccactttca  agttcttat  ttagaataa  cattattgt  tgtatttgt  23040
tcatacagt  gatgacatg  tccttgaaa  agaaattgt  ttattcatt  ttttacccc  23100
atgcctaga  aggtagatg  ccagtaaat  gttattgaa  aatttaata  ataatgaag  23160
aaatgtggt  aataatcag  gaaacatct  cacagacac  aagtaagta  agtgagccc  23220
attcataag  aatttagac  aaggcacaa  agaatataa  atagcatca  acaattcac  23280
cggactgaa  caatgataa  agatataaa  gtgcttgtc  gcttcctcc  cctcaaacc  23340
cctctttgt  gatacccca  ttcagtaaa  ggcaccacc  caaagtaca  gccaggaac  23400
gggatataa  cctttaatt  gtgccccaa  tttgattat  tttactcct  aacactaat  23460
cagtgtcac  ttctccagc  ctaccacca  tgcctttag  ttctggatt  attttctct  23520
gcctagagt  tggtaggaa  ctgcttctg  ttcattctc  tcaaaccat  cttggtttg  23580
atgtgatct  tcttatcag  aactgtctt  ccagttgct  tcttaacca  caactctgg  23640
taagtcact  acctgctta  tgtctttca  ttactccgt  tggcccctg  gataaagta  23700
atcctttaa  aaggtcttt  cctgtgatc  ctgcttatt  ttccagttt  aaatcccca  23760
tgtagctga  ttttcagtc  cacaaaaat  ctttgtgtt  cttacacac  tcatagtct  23820
tcagcactc  tgtgtttgt  catgtggca  tcttctgtt  gaatccttt  cctgaaact  23880
tgtacaact  tttctttag  ttttgggtt  ttcttgttt  ctttacttc  aattcttta  23940
ccatactaa  gactacccc  taccccagt  caaattgtc  cagcatcaa  catcattgt  24000
ctaatccaa  cattgttgg  attttcatt  tactgttgt  gtatatttt  aatatctac  24060
gtggcaacc  ccagcctca  tgagctgcc  gcctgggca  tctacattg  ctctctggg  24120
accaaatgt  gtttctact  atgccttgt  tttaaagtt  catgtattt  gagtctagc  24180
ctaacccta  ccctacttc  ccataatat  tttaatgta  aggtttgca  tacataagc  24240
tttcaggaa  gcctacgtc  tattaaaag  gaaatactt  gcctggcat  gtggcccac  24300
tctgtaatc  cagcccttg  gaggctgag  caggcagat  acttgaggc  aggagctcc  24360
acatggtaa  actgcatct  tactaaaaa  tacaaaaaa  aaaattagt  gggcatggc  24420
tggcacgcc  gtaatccca  ctactcaag  ggctgaggc  tgagaattg  ttgaaccca  24480
aaggcagaa  ttgcagtga  ccaagattg  gccattgca  cccagcagc  tgagtaata  24540
agcagacct  tgtctcaaa  aaaaaaaaa  aaagaaaga  agaaaagaa  agagaaaca  24600
ttgtgttgc  tgcaatggc  cacacttat  atcccagca  tttgagagg  tcaggcaga  24660
ggattgctt  aactcagaa  ttcgatacc  gactgggta  catagcaag  cctcgtctc  24720
actaaaaaa  aatttttaa  tggccaggc  tggtgatgt  cgcctatag  cccagccac  24780
agggagact  aggcaggaa  atggcctga  cccaggtgt  tgaggctac  gtgagccat  24840
attctgcta  cgcagtcca  cctgggtga  agagagaga  accctgtct  aaacacaaa  24900
caaaacacc  gaaacactt  aacaattct  atttttgaa  agttacaga  aagttggag  24960
aagacaaac  tgtaaaaat  agtacatgt  cagtttcta  atgtagtat  tacaaaatt  25020
aacgtattt  ttaataaac  tgaaatggg  gcatacaga  agagtgatt  ctgcttctt  25080
aggaatcac  gtggggtct  gagagatgg  atagatttg  ctaaaataa  agtgaaaaa  25140
aacctttca  gaagagaaa  taaaacacc  agacatcac  aattgctaa  cgtctaatc  25200
ataactcaa  tttcaatga  atgcacacc  ttcctctga  ttgatcatc  gtttctttc  25260
tattcttca  aatttattt  attcaaatt  aaatttcat  gagttttta  aaaatatta  25320
ataatcgaa  ttctaaata  ttcatgaga  atgttattg  tgagttgtg  ggaaacaaa  25380
acctcataa  ttgctggtg  gagcataaa  tggtgcaat  agttcagag  ggagctaga  25440
agacaatca  tatatatag  aacattatg  atgtattta  cttttgccc  agaaactca  25500
tttctagat  tctatttgt  aggtacact  gcaaaaata  aaaaacaga  atatggata  25560
gtccattat  tacagcatg  tttgtagta  taaaagact  gctaaataa  ttagggcac  25620
tctacaaat  gagtactac  agattataa  aaggagaaa  cttgtggtt  aagaagact  25680
attctggag  tttgttctc  tcaaagcaa  gctatgact  aaatttacg  tattacttc  25740
acaaaacat  agaacttga  tatggaata  agatcttag  gaagctcag  ttgtttttc  25800
tgggaagaa  ctagtgtga  ggaaataat  attggggtt  taaaggcat  tgcatgtga  25860
cttttgatc  actctcata  atgcatact  cataccagt  agcttaaaa  aactaacac  25920
gcttaaggg  atgagaatg  agtaagatg  tgaggagag  tatgtgttg  gaaagatca  25980
gagattttc  gtcatgaat  tagagtcag  tctgcccag  agaggaaaa  tgacaagat  26040
atttttatt  ggttttacc  tctgttact  tgtgtgccc  catgttata  tgactagca  26100
tttcatatt  tgcacaatg  acgtcacac  gaaatataa  caccggcca  gcgcggtgg  26160
tcacgcctg  aatcccagc  ctttgggag  ccgaggcgg  tggatcacg  ggtcaggag  26220
tcgagacca  cctggctaa  acggtgaaa  cctgtctct  ctaaaaaaa  acaaaaaat  26280
agccgggca  ggtggcggg  atctgtagt  ccagctact  gggaggctg  ggcaggaga  26340
cagcgtgaa  ccaggaggc  gagcttgca  tgagcagag  tgcgccact  cactccagc  26400
tgggggaca  agcgagact  cgtctcaaa  aaaaaaaaa  aaaagaaat  taacacctg  26460
aaatagttg  ccacagaag  gctgtcata  cagttgaaa  aaggaaaac  atgtaagtc  26520
acaatgggc  ggcagagga  ttttcatag  tggtggtgc  aggtcgaaa  tacttctct  26580
ctcctttct  tccactcag  tttccaaaa  ccatttcag  aacaggact  catcttatt  26640
gagatgtgg  aagatgcag  gaggaatct  aaatctggg  ctgattgtt  ctcatccag  26700
aaaatgtag  cttacttcc  aaggtctat  ggatacagt  tctgagggc  agggcctta  26760
agaccgtcc  gctgagggc  ttcttcacc  cgttatttc  caggctgta  ataatgggg  26820
tcaacatgg  agtcataac  gtgtaggac  atgatagca  cttcttgcc  tcaggtgaa  26880
tatttgatt  aggccggaa  taggtgagg  ttaatgata  atagaaaag  gagacaaca  26940
ggaggtgtg  ggaacatgt  gaaaaggct  tattcttcc  tttagctga  gggatcttg  27000
ggatggcag  agcaatgtg  gtataggaa  acaagatca  caagcaggg  atcatgacc  27060
ccagaatgg  tccgacgat  gcgtagatc  caaagagtg  tgtgtctgc  cagaccagc  27120
tcagcacag  tgggctgtc  cagaagaag  ggttcacct  gttggtgcc  cagaatgga  27180
aactgaaga  ccatgtggt  tgcacagta  ctacaggaa  gcctgggaa  caggaggta  27240
cagccagtt  ggcacgagt  ctttggttc  tgatgactg  gtagtgcaa  ggactgcag  27300
tggccacat  gcggtcata  gccatggta  ccaggagga  gcattcagc  actccaaag  27360
agaagaaga  atacatctg  gtggcacag  caaggaagg  gatggttgt  tcctgggca  27420
gcagggtcc  cagcatttt  ggcacaatg  ctaggttga  gccaatctc  aggaaagat  27480
agtttctga  gaagaagta  atggggctg  gtagcatgg  gtcagctag  gtaaccaga  27540
tgatgaggc  gtttcccat  agggtgacc  ggtagatgg  tagaaatgt  agaaagagt  27600
atgactgta  ttcagtagg  agggaagag  agctcatga  gataaactc  cttattctt  27660
tccagtttc  tgtagctat  agtgtgggc  gaagtcccc  actgtggtc  tggagaaag  27720
ttattgatt  gaagtcaga  tctcaattt  tttttcaga  tcgttctta  tgtcaggga  27780
agaggcaag  tcagcacct  aggcagagg  agtgccttg  gttgtctaa  aataaaaca  27840
aataaatag  agccagagc  taatctctg  gatgggcct  aatcagctt  tagaggagc  27900
gatatttct  ttcacacct  aagttattc  gaaagggca  gcaaagtca  aatcacaag  27960
ttctgaagg  tccatcaaa  gatacattt  gggagaaag  gatgtttct  aaaacactt  28020
aacttatga  acacaccaa  tgtttataa  ctcgtaaaa  aacacatac  tttaaattt  28080
tcaaaactt  agaaatata  ttataacta  catgaagaa  gcatataat  tgttttcta  28140
tcttcatga  cctttcttg  ctggctaga  tttgagagg  gggtgaaag  ttagcatgt  28200
ttgaggacc  tttacatat  catgttttt  ttcttttat  tctctggtt  atacatgag  28260
aaactgatc  cagataatt  aagaaacac  aatcacatg  aagatcttg  atccaaacc  28320
catctattg  attacaaaa  ccttcagat  tttactaaa  catgctttg  tggactgtc  28380
tgccttatc  gatgactaa  ttattaatt  gtaggagaa  tagaattgg  atttctgca  28440
aatcacagt  aagacagac  aagataagc  cgagaacca  catcattag  attaagatg  28500
ttaggagat  tcctagaca  aactgaatc  caattttgt  ttactggtt  ctaatttgc  28560
gttggttat  tagaggctc  tcttattgt  ttcgtaatc  agaatattg  agtctagtg  28620
agaaatggt  atattaagc  ggaaaatga  attgagagg  tgggataaa  aaaaaaaga  28680
atgaatgtg  ttagcaaac  atggttaaa  aaaattaat  ataaaaatt  aaaacttta  28740
taggaacag  aaaaaccag  actgacaca  agtaaaaga  aaacaaaga  atggtcagt  28800
ttttggata  attacatta  tagacttat  ttacatgct  agaattttg  actttattt  28860
atagatgag  agattcacc  gaatatttg  agctgcaga  tgacattgt  ataatgcta  28920
ttagaagga  cactctgac  ttgttgata  aatgggata  agaagggat  aaaagctgt  28980
ggcctcgga  caagaagac  aggtggtat  tctataatt  ccctccgtc  ttacgcaca  29040
tccattttc  agcagcaga  aacttattt  aaagaggct  aatattagt  aggtcttgg  29100
gaataattt  aacttcaag  ttatgttta  aattccaga  aatctatga  ggaaaaaac  29160
ccattctta  aaaagaatt  taatcaaac  gatctaaga  ttctcagaa  tgctaaaca  29220
taaatgaag  aatgtctac  gtttttagc  cggtttcag  aaaacaaat  taagtttaa  29280
aaataataa  agaaccaat  atgaaaaga  agatcatct  aactagaaa  tctttcact  29340
taggccagg  gtggtggct  atgcctgta  tcccaggac  ttgggagcc  gaggcaggt  29400
gatcacttg  gcctaggag  ttgagacca  cctcagcaa  gtggcgaaa  cccatctct  29460
caaaaaatg  agaaaatat  cagttgtgg  ggcatatgc  tgttgtcct  gctactcag  29520
aggctgagg  gggaggatc  ccagagctc  ggaggttga  gctacattg  gctgtgatt  29580
tgccactgc  ctccagcct  ggtgacaga  tgagactca  tctcaacaa  aaagaaaaa  29640
aaagtaaag  aaaaaatag  aactctctt  ctgtcattc  aaggcaagc  agcccataa  29700
taaacagaa  aggttatgg  agatatgaa  acaaaacac  ttaggttaa  gagatgaaa  29760
ccaagatat  aaatcaatt  tttcccttt  caaaaacaa  agtctgaaa  gaagttgaa  29820
gacattaaa  tgtctttat  acttactct  aacaaagcc  tataaaata  tgaatatcg  29880
ggccaggca  ggtggctca  gcctgtaat  ccagcactt  gggaggcca  ggcaggagg  29940
tcacttgag  ccaggagtt  gaaaacagc  tggccaaca  gctgaaaca  cctctctac  30000
aaaaataca  aaattagct  gccgtggtg  cacatggct  taatctcag  tacttggga  30060
gctgaggca  gagaattgc  tgaactggg  aggcagagg  tgcagtgag  caagactgc  30120
ccgctgcat  ctagcctgg  tgacagaag  agactctgt  ttaataata  taataataa  30180
atagaatat  gaataagta  tcatgaaaa  gacagtgtg  ggccagaaa  gaccacctg  30240
gggacaaaa  aaagccatg  ttattgaag  taaaccttg  ggagcaaaa  gccagaaac  30300
taagaaaac  gagtcaatt  gaatacaaa  ttgaaaaat  acacccaag  tactgggaa  30360
aattatgaa  acataacaa  tataagagg  ataatgaag  aaaatacaa  aaataaaat  30420
actataaca  gtattccag  atgacagaa  gaatggaga  gggtagaaa  aatatccaa  30480
gaagtacca  aggaagaat  aatgtctct  atctaatgg  agagatgac  ttttgaacc  30540
aaagaatcc  taagtatga  agaaaattt  aatatattc  cacaaacat  tttttattt  30600
actgaaaga  tttttttta  ttctgaaaa  agagaaaag  tctgataag  aaccaaact  30660
gaaaatgat  aaaacaaaa  aaaacaaaa  aaaaatacc  cctataaac  acaaccaaa  30720
aaaaaaata  agtattcac  attagggaa  tgcatatat  cttataaag  ccccaatga  30780
atatcacta  acacatata  gaatgggtt  aaaaaaaag  gacaacacc  aatgctggt  30840
aggatttga  gaattggat  attcataca  tgctcatga  aatgtaaat  gtatcagag  30900
tgttcaatc  tttggcttc  ctgggccac  tgggaagaa  aattggctg  taagctaaa  30960
ttaaaaaaa  agaaatctc  taaaggttt  agaaagttt  caaatttgt  ttgggccac  31020
tgcaaagcc  tcctggtct  catgcagcc  gcagggttg  acaagcttg  tatagccac  31080
gcagaaaac  gtttgacag  tctttaaaa  aactaagca  gtaactgtg  tacaaccag  31140
aattgtacc  ttgggtatt  atccctgag  aatgaagac  atgttcata  aaaaacatg  31200
atattcctc  gtgctgtat  cataatagc  tcaaattgt  aaaaaccca  atgatgaaa  31260
aaattatga  gcatttata  cttagtaaa  tcagcaata  agaggatga  ctattgata  31320
atgcaataa  atgaatgaa  ttacagata  ttctgagtg  ataaaacag  cacatattt  31380
attattcca  ttacataac  tttctgtaa  gacaaaatt  taggaatgg  aaagagatt  31440
gtgattgcc  gtgactaac  agagggtgg  gacaagagg  aagcaggtc  ggatataaa  31500
gaccaaggt  ggagatttt  ctagcaatg  aatcctctg  tatggaggg  catttggat  31560
tttgcaaat  ctttcatca  tacatgatt  tgttgacag  aatgattat  tctcctgta  31620
aactccata  ttactcaca  aaaaaactg  taaaaagaa  tgctaatga  tttttttaa  31680
tctgctaaa  atagagttg  aataagctt  gaacacatt  tttaaaata  taaaaga  31737



<210> 1215
<211> 317
<212> PRT
<213> Homo sapiens
<308> AAG45206
<400> 1215

Met Ala Ile Gly Asn Trp Thr Glu Ile Ser Glu Phe Ile Leu Met Ser 
  1               5                  10                  15
Phe Ser Ser Leu Pro Thr Glu Ile Gln Ser Leu Leu Phe Leu Thr Phe 
             20                  25                  30
Leu Thr Ile Tyr Leu Val Thr Leu Lys Gly Asn Ser Leu Ile Ile Leu 
         35                  40                  45
Val Thr Leu Ala Asp Pro Met Leu His Ser Pro Met Tyr Phe Phe Leu 
     50                  55                  60
Arg Asn Leu Ser Phe Leu Glu Ile Gly Phe Asn Leu Val Ile Val Pro 
 65                  70                  75                  80
Lys Met Leu Gly Thr Leu Leu Ala Gln Asp Thr Thr Ile Ser Phe Leu 
                 85                  90                  95
Gly Cys Ala Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Val Ala Glu 
             100                105                110
Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 
         115                120                125
Ser Pro Leu His Tyr Pro Val Ile Met Asn Gln Arg Thr Arg Ala Lys 
     130                135                140
Leu Ala Ala Ala Ser Trp Phe Pro Gly Phe Pro Val Ala Thr Val Gln 
 145                150                155                160
Thr Thr Trp Leu Phe Ser Phe Pro Phe Cys Gly Thr Asn Lys Val Asn 
                 165                170                175
His Phe Phe Cys Asp Ser Pro Pro Val Leu Lys Leu Val Cys Ala Asp 
             180                185                190
Thr Ala Leu Phe Glu Ile Tyr Ala Ile Val Gly Thr Ile Leu Val Val 
         195                200                205
Met Ile Pro Cys Leu Leu Ile Leu Cys Ser Tyr Thr Arg Ile Ala Ala 
     210                215                220
Ala Ile Leu Lys Ile Pro Ser Ala Lys Gly Lys His Lys Ala Phe Ser 
 225                230                235                240
Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Tyr Ile Ser Ser 
                 245                250                255
Ser Leu Thr Tyr Phe Trp Pro Lys Ser Asn Asn Ser Pro Glu Ser Lys 
             260                265                270
Lys Leu Leu Ser Leu Ser Tyr Thr Val Val Thr Pro Met Leu Asn Pro 
         275                280                285
Ile Ile Tyr Ser Leu Arg Asn Ser Glu Val Lys Asn Ala Leu Ser Arg 
     290                295                300
Thr Phe His Lys Val Leu Ala Leu Arg Asn Cys Ile Pro 
 305                310                315



<210> 1216
<211> 669
<212> DNA
<213> Rattus norvegicus
<308> AF091563
<400> 1216

ggcaacatg  ctctcctgg  gattggcta  actttttct  tcataccca  gatgctgca  60
agccttgtg  gtgaggccc  agggatctc  cgggaggga  gtgccacac  gatgttttt  120
ttcacactt  ttggtataa  tgagtgctg  ctattggcg  ccatggcct  tgaccgctg  180
atagccata  gctccccac  ccactatgc  acccgaatg  gtcgtgggg  atgtgccca  240
ttggcaatt  tttcatggg  aacaggttg  attgtgggg  tgggacaaa  caattttat  300
ttctcctta  acttttgtg  gccctgtga  atagaccac  tcttctgtg  ccctttcca  360
cttttcctg  gcacttgcc  gtgggagat  catcccaaa  cggaggctg  catctttgt  420
gtagcaatc  tctgtatat  tagtccgtt  ttactgatc  tttattctt  tgtcagaat  480
ctggtcgca  tgctcgtga  gccttcacc  gaggggcgc  ataaagctt  ttccacctg  540
tcgtcccac  tacttgtag  cacactctt  tatggctca  gatccatta  ctacttgag  600
cccaaatct  gccattcac  aggaattga  agactcttg  ctctcttnt  cacagcagt  660
acatccatg  669



<210> 1217
<211> 223
<212> PRT
<213> Rattus norvegicus
<308> AAC64586
<400> 1217

Gly Asn Met Ser Leu Leu Glu Ile Gly Tyr Thr Phe Ser Val Ile Pro 
  1               5                  10                  15
Lys Met Leu Gln Ser Leu Val Ser Glu Ala Arg Gly Ile Ser Arg Glu 
             20                  25                  30
Gly Cys Ala Thr Gln Met Phe Phe Phe Thr Leu Phe Gly Ile Ser Glu 
         35                  40                  45
Cys Cys Leu Leu Ala Ala Met Ala Phe Asp Arg Cys Ile Ala Ile Cys 
     50                  55                  60
Ser Pro Leu His Tyr Ala Thr Arg Met Ser Arg Gly Val Cys Ala His 
 65                  70                  75                  80
Leu Ala Ile Val Ser Trp Gly Thr Gly Cys Ile Val Gly Leu Gly Gln 
                 85                  90                  95
Thr Asn Phe Ile Phe Ser Leu Asn Phe Cys Gly Pro Cys Glu Ile Asp 
             100                105                110
His Phe Phe Cys Asp Pro Phe Gln Leu Phe Leu Gly Thr Cys Leu Trp 
         115                120                125
Glu Ile His Pro Lys Thr Glu Ala Ala Ile Phe Val Val Ala Ile Leu 
     130                135                140
Cys Ile Ser Ser Pro Phe Leu Leu Ile Ile Tyr Ser Tyr Val Arg Ile 
 145                150                155                160
Leu Val Ala Val Leu Val Met Pro Ser Pro Glu Gly Arg His Lys Ala 
                 165                170                175
Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Thr Leu Phe Tyr Gly 
             180                185                190
Ser Gly Ser Ile Asn Tyr Leu Arg Pro Lys Ser Ser His Ser Pro Gly 
         195                200                205
Ile Asp Arg Leu Leu Ala Leu Xaa Tyr Thr Ala Val Thr Ser Met 
     210                215                220



<210> 1218
<211> 31737
<212> DNA
<213> Homo sapiens
<308> AF321237
<400> 1218

ctgagctga  ccaaatccc  gagcctcta  gaactaacc  gatagcacc  tccaccaga  60
ggacggcaa  tcaaaatgt  gcaatgttt  aattacctg  attctcgaa  tttattttt  120
tatcagctg  tttgataat  cactatttt  ctctttaga  gcaattctc  attagtttg  180
tgtgattga  tatatagat  ccttaaacc  atattggct  tgaatctat  atattccaa  240
gaccactgt  ggcactggg  atgaaacaa  ttggcccct  ccctctgga  ttctttagt  300
ttaggaact  ggttttcag  ctgtatccc  agtctttag  atatgcttg  tacacagta  360
ttgctcaaa  aataagatt  attgaatat  caaagtatg  tgggtgccc  aggaaagta  420
tgatacctt  atttagtgg  catgtcttt  agtagaggg  ctatgcgga  caaaaaaca  480
tggggtgta  aaatgcagt  tgttctagt  agttggtat  ggataaggc  ggtaaggtt  540
cctgcagat  gatacggga  ggtggaatt  atctatatt  agtgtgggg  cgtaagtaa  600
catcaagca  agatgtaat  attcataat  atgttttat  tatcagtta  tgaatgagt  660
gatttccct  gaaataaag  taggcactt  tataactgc  aggcactac  gtttttaga  720
attggcagc  tctatcaaa  gtaaagata  gcctaccct  atatattcc  tcttggata  780
agctcgtat  tagcaattc  aatgtttgt  gtttaccct  acaggtata  tggtaacag  840
gaaaaacaa  atatgtata  gaatgttca  aacataatt  tttgtggta  cataaattg  900
ccccaatat  aatgttcat  aataagaga  tagttaact  agttttggt  taactgtag  960
ttaactgta  ttaaactgt  gtgtggaat  taatgaaat  aatagcaag  cataggtat  1020
gctatatat  ttggtcaag  agtgtctcc  agataatag  gattgttgg  aaaattaag  1080
cattaaatc  tatgttaac  acaaaagtg  gcatactca  gtacataca  atatgcata  1140
ttgaattaa  agacatctg  aaagatgta  accaacctg  gatctatgg  tactaatgg  1200
aagggtatt  ggcttgagg  tgtttggaa  gagacttac  attaccata  atttgggcg  1260
tgcatgttg  acacaccac  caacttacc  tttaaagtg  ataattcaa  ggcttttag  1320
atattcaca  agttatgca  ccatcacca  aatcaattt  agaactttt  cgttactcc  1380
aaaagaaac  atacattcc  tagtcatca  catccagtc  tcctataac  ccagcccta  1440
gcaacaacc  atctacttt  tttctctat  gatttgcct  ttcttgaca  ttaatataa  1500
tgaaatcat  caatatgtc  tcctttgtg  ctacttttt  cacttaata  aatgttttt  1560
acgtttatt  atgttgtac  atgttcaat  ctttatatg  atatatcac  gtttttttt  1620
tttgtttgt  tgtttgttt  tttttgagg  ggggtctct  tctctcaca  ggactgaag  1680
gcagtggag  gatctcagc  cactgcaac  tctgcctac  ctgttcaaa  gattcttct  1740
cctcagcct  ccaactatt  gggactata  gcatgtgcc  tgatgccca  ctaattttt  1800
tatttttag  agagacggg  tttcaccac  ttggccagg  tggcctcga  ctcctgacc  1860
taagtgata  acctgcctt  gtctctcaa  gtactggga  tacaggcgt  agccaccac  1920
cccagctga  atatcacct  ttctttata  attcaaaga  atttcactt  ttgtctttg  1980
atcactgca  tttttgagt  ttatgaata  tgttgccat  aacattcat  tataagttt  2040
tgtgtgcaa  atatgcttt  agttctctt  ggtatatac  tactggtgg  gtggctgat  2100
catatggta  cctgctagc  atcctagta  gtgtaaagt  gtatgctat  gtggttttg  2160
tttgcattt  ctttatggc  aatgacatt  aacatattt  catgtgcct  ctggccatt  2220
gcatacctc  tctggaaac  atgtctatt  agattcttt  cccagttat  aattatatt  2280
ttggccttt  tattaccag  ttatgtttc  tatatattc  aaatataag  cccttatca  2340
atacagaat  tgcaaaaat  ttctcccac  ctgtgggtt  tcttttcac  tccttaatg  2400
tgtcttttg  agcacaaac  tttttaatt  tgatgatgt  caatttatt  atttttttc  2460
tttgttctg  aaaatatat  tttgatgta  atttaaaat  caattaagc  aacaaaatg  2520
taaaattaa  taacttatc  tcaaaactg  ggaggaata  agagttcct  ttaaggatt  2580
ggtaagagg  ttttatcct  tcaaagatt  tagagtttg  tggcactgg  ttttatttt  2640
ccattgaat  aacatccac  cctccattt  cctgatata  tggtaatat  gtgtaacca  2700
tacatttat  tgatttgat  tgagactgt  tttgttttg  cagattttc  tagatgtgt  2760
aaagaggag  ataacataa  gaataatct  tattttgag  taaaaaaga  ccttttaag  2820
aattaatct  tacattgta  agtaaaaca  taaggtgaa  ttgttttca  gcttcttcc  2880
ctggtggtt  aaataaaag  ggagaagag  aaagaaatt  ggtcaaact  ttcccagat  2940
ggttgttag  ggtaacttt  gcccaggac  gctacattc  tgtctggag  aaagatgtt  3000
caggagaaa  cccaggaag  gaggaaagg  gtgtagagt  catggctta  cagtagtgg  3060
caaaggtgg  agggttata  attggattt  gtcatacag  tgatgcatg  tggactgag  3120
tgtttgctt  aggccttct  cctgcaaag  gagcaggga  caatgctaa  aatctaaag  3180
accaaacag  taagtagaa  tgcaaaggg  ccttcctcc  aatgccaaa  tccaacttt  3240
gtctgaaga  cagttagga  ttgaaatct  tcatttctt  gactcacag  ccaatccag  3300
tgctgagac  ctgttacta  attatgtag  gtgtaatta  gtctttttt  tttttttaa  3360
aaatctcct  gggattcct  taacccaag  gagttctgc  acttggagt  aaatgttac  3420
tctttattt  tattttccc  taactgaaa  ttgatgttt  cttccaatt  gaatgcaag  3480
aaccaaccc  caccaatat  agaagtatt  atgactttg  cagcagtag  aattataag  3540
atttttata  tgtattgca  ttgttggag  gatctccaa  tatttaaac  catcattat  3600
ttgaaatga  gatggttat  agacccacc  ctacatttc  aaattttag  gtattaata  3660
agaagcaca  atattgctg  ttacaaatc  gttttctaa  attatttcg  taactgtat  3720
ttgatataa  tggtttcct  agtaatcct  tacatttta  ttgatgtat  taaaacgtt  3780
ttctgagat  ctttcacca  acagttaaa  gattgatag  ccaacccgt  tataggatc  3840
taaacttta  actttaaag  aaatttatt  cccttcttt  tggaacagc  ccacaaaat  3900
ggattatta  ttcaaatct  tctagggat  ttggcaaaa  ttctaaatg  ctctgctta  3960
ctatgtgat  aaattatta  ttgtttaat  aattatggt  atttatgaa  tgaagttct  4020
tgctatgtc  tgtaaagga  acagaggtg  aaaagacat  gaaactatt  tcaaaggaa  4080
ttttacttt  gcgggggga  tggacagat  atgcatata  tttttagca  agagagctg  4140
ggagtagtg  tgtttgggc  gagtatgaa  ctagtcacg  tggtggctt  aaatgaaaa  4200
tctgttttg  tggtgtgtc  gttatgttg  aagttcatt  acagttgag  ctgaacaga  4260
ctcaagctg  ggcttcaga  aggattccc  agggtatcc  gagttaatc  ttggtttcc  4320
agctcctgt  agacaggtt  gtttcttaa  taaaacata  cagtacttt  gctctttct  4380
atttcttat  ccttcgtgt  tgtcctttc  cggaaaata  aacagaaaa  tatattatc  4440
taagcgggg  agaggagat  tgacaagag  acttacgac  caggggttt  agttaagaa  4500
aaacagaaa  taaatggca  gactttata  atgaactca  tctgtattt  atattgtat  4560
attaaaagt  tggtattca  agtgagaaa  ataatttta  aaatctatt  ttgccagat  4620
acaccaaca  tgaatgcaa  atcttttaa  gtttgtttt  caacactga  aatgttcca  4680
tgaaagaaa  atgatcatc  tatgaaggg  gttcttgaa  ttttcagta  aaattgggg  4740
agttcctaa  cctgcactt  tgaattata  aattttata  gtatgcctg  ctatggtta  4800
cacatagtg  cttcttact  aaaaggaca  caaactatg  gacagataa  tcagacaca  4860
gtgacagaa  tcctccttc  gggactctc  gatgggcca  acaccgagc  gctgctatt  4920
atcgtatta  tgggtgtct  cctggtcac  gtgcttgga  atctgcttc  aatctccct  4980
gttcatgtt  actcccaac  tcacacacc  atgtatttt  ttctctgca  cttgtctct  5040
gctgacctc  gtttctcta  caacatagt  cctcaggca  tagtccacc  gctttccag  5100
aagaaggtc  ttgcattca  actttgcgc  gctcgactt  tctttttcc  catttttgg  5160
tgtacccag  gcgcccttc  tgcagtgat  tcctatgat  gctatgttg  aatctgcaa  5220
cctctgcgt  accctaaca  catgacctg  aaagtgtgt  tccagctgg  aacaggatc  5280
tggaccagt  gcattctgg  gtctgtggt  gacaccacc  tcacactga  gctacccta  5340
cgaggcagt  acagcattg  tcatttctt  tgtgaggcc  ctgcactat  gatcttagc  5400
tccacagac  cccatgcat  agagatggc  atttttctt  cgggggttg  gattctcct  5460
atacctgtt  ttctgattc  ggtatccta  ggccgtatc  tagtaactg  ggtcaagat  5520
aagtcaact  tggggagtc  caaggcatt  tctacctgt  gctcccacc  catggtggt  5580
atacttttt  atggatcag  aattatcac  tacatgaca  ccaagtctt  caaacagca  5640
gaaaaatcg  tgtctgttt  ctatgcaat  gtgactccc  tgcttaatc  cctcatcta  5700
agcctgaga  acaaggatg  gaaggcagc  ctgaggaaa  tagccacaa  gaatttccc  5760
tgaaggctt  gaatctcac  ctgacagtg  gctcagaga  ccttttggc  tcctacttc  5820
aagacttgc  gggaagaca  ggaatcaac  caggtggat  ggattttta  aaatgtaca  5880
tggcacact  ggtttctca  gtcacctgc  tggccccct  ccaagttgt  ctttccttc  5940
ttttcctcc  ttccttttc  ttccttact  ttctaaagc  ttttaataa  ctttctcct  6000
ctttgaaaa  aaaagtaca  atacaccat  gaatactat  cagccacag  atagaatga  6060
atcatgtca  tcgcagaaa  atagatgca  cttgaaacc  ttatcctaa  tgaactagc  6120
caaaaacag  aaaccaaat  cttcatgtt  tcactcata  gtaggaact  aacattggg  6180
acatatgaa  acaaaggtg  gaacaatag  cattgggga  tactagatt  tgggaggga  6240
ggggaaggg  taaaaaaac  acctattac  tactcacta  ctgggtgat  gattcattt  6300
tactccgta  ctcagcatc  catgatata  ctctgtaac  aacctgcgt  tgtaccctc  6360
attttaaaa  aaaagttga  aagaagaaa  aatgcacat  agatttcaa  ttttcacac  6420
tatatgaaa  tagaattta  atcatgtca  tagtaattt  atatggatg  catgacaat  6480
aaataatat  ttaatatat  ggataaaat  aacttatat  attaaagaa  acttgctgg  6540
tagccctct  ctttgtgaa  ctaaaatat  gtaagactt  aagtgatgg  tatggtaat  6600
accctgatt  gattattat  caatgtttc  atgcattga  acatcacac  gtattccca  6660
actatatat  attatgtca  ttgtaaatt  aaaattaat  aaaaatatg  taagattct  6720
attcttggg  cttatccat  gacacaccc  ctatccttc  tcctgcatt  ctttcatag  6780
aggagaagg  caataattc  tggagcaat  ggaaggagg  tatgcttcc  tctggttgg  6840
cctttgaca  ctaagggtt  agaaatccc  cgagaaaca  acatatttt  taagccttg  6900
aaaatctac  tttttaata  tgctgtgta  tatcacctg  ctatttcag  tcttacttc  6960
agtcctttt  cttttggta  ttctgaatc  ctctgcatc  tcaaatgat  aataaatag  7020
cattactga  tcacttact  tgagctagg  gctacatgt  tgttggcat  tgcacctgt  7080
tgtgtgctt  acatgggta  tgaagagca  gggtacaat  aagcagaat  tatgagctc  7140
gctctcctt  tcacactct  ttagaaaca  aaggatcat  tttatcagg  tacatcttc  7200
taaagatga  tataggagt  gtggaaacc  gcaagaaat  gtgacacat  ccaagaata  7260
tgacacata  caagagtga  aagctgtaa  taacgataa  cctgaatga  caagaggag  7320
gaactagaa  ctggagagg  tagaaatat  ctaagggca  aaggcagta  ctgtggact  7380
aggctatgt  aaggcaagg  agccatggg  agaaatatt  ctcaagccc  ttttccacc  7440
gccttctga  cccccacta  tgtattcca  ttagaagcc  gggaacaag  agccttttg  7500
tataatcca  aaaagatgt  aaacattct  aagcacata  caagctgaa  aaggataga  7560
ggtagatct  gaaaggtca  ctggtgaag  acacacctt  tgccctcag  atccacttc  7620
ttcagtgat  aattcatat  tctaataca  ggaacacat  aagttccat  aagaactat  7680
tcatagcgg  atgatatca  gtagctcac  cttctactt  ctacataaa  gaatagctc  7740
tgtcatgat  atttatgta  gttgaaaga  gaagagcaa  aaaggcaaa  aattagcag  7800
aaacatagc  attgtagct  ctaatcctg  cccagacat  agttgataa  tatagcttg  7860
tctttcact  ccctttcat  gatttctta  tttctacct  aaactcagc  cactggagt  7920
ttttaacaa  gtgtggcaa  ctaaaactt  ttacctgta  tatttgagt  attgatgat  7980
ctgttcctt  ttttttaac  tttagtttc  cgggtacat  tgcaggttt  ttatatagg  8040
caattgcgt  tcacaaggg  ttggtgtac  gattacttc  tcacccagg  aataagcat  8100
gtacctgat  ggcagttta  tttatattc  cccttctct  accctcaac  ctccagtag  8160
ccacaatat  tgttgttct  ttatttgta  ccatgtgta  tcaatattt  gctccaact  8220
ataagtgag  acacacagt  tttggtttt  tgttcctgt  ttaagatag  ataatagcc  8280
ctagctcca  ttatgttgc  gcaaaagac  tgatctcgg  ctttttcat  gctgtatag  8340
attccatgg  gtatatgta  cacatttcc  gctattgat  ggcatttag  ttgattcca  8400
gcctttgct  tgtgaatag  gctgcgatg  acataaccg  gcacgtgtc  ttatggtag  8460
gtaatttat  ttcctctgg  tatataccc  gtaatggca  tgttgggtc  aatagtagt  8520
ctgttttaa  ttattcaag  aatcaccaa  ctgctttcc  cagtggctg  actaattta  8580
attcccacc  gaaaagtgt  cccttttct  tacaatttt  ccagcatct  ttttgttgt  8640
gttgttttg  ctttttaat  gtagccatt  tgactggtg  gagatggta  ctcattgtg  8700
ttttgattt  cacttctct  atgattagt  atgttgagc  ttttttcat  tgcttattt  8760
ccacttgta  gtcttcttt  gaaaagtgt  tgttcggca  cctatagaa  gggagaaaa  8820
ttttgcaat  tatccatct  acaaaggtt  aatatccag  atctacaag  tccttaaac  8880
aattttcaa  aaaaagcaa  caagcccat  aaaaagtgg  tgaaggata  gaacagaca  8940
ttctcaaaa  aagacattg  tgtggccaa  aaacatatg  aaaaaaaaa  ctcatcatc  9000
ctggtcgtt  gagaaatgc  aatcaaaac  ataatgaga  accatctca  accagtgat  9060
atggtgatt  ttaaaaagt  aggaaacaa  agatgctgt  gtgactgtg  agaaatagg  9120
atgcttttt  gtgggagtg  aaattcact  attcaacca  tgtgttcaa  cattgtgga  9180
gacagtgtg  caattcctc  aggatctag  accagaaat  ccatttgac  cagaaatac  9240
attactagg  atatactca  aggattata  atcattcta  tataaagat  catgcccac  9300
tacgtttat  gcagcactg  tcacaatag  aaagacttg  aaccaaccc  aatgcccat  9360
agtgataga  tggattaag  aaatgtggc  catatacac  atagaatac  atgcagcca  9420
gaaaaagga  gagttcatg  cctttgcag  gacatggat  aagctggaa  ccatcattc  9480
cagcaaact  tcacaggaa  aaaaaacta  acaccgcct  ttctcactc  taagtggga  9540
ttgaacaat  aggacacat  gacacaggg  ggggaacat  acccaccgg  gcctgtcgg  9600
ggatggagg  ctaggggaa  gatagcatt  ggagaaata  ctaatgtag  tgactggtt  9660
atggccaca  caaaccacc  tggcacgtg  atacctatg  aacaaacct  cacgttctg  9720
acatgtatc  cagaactta  tatgtgtgt  tgtgtgtgt  tgtgtgtgt  tgtgtgtgt  9780
tgtgtgtgt  tatagatgt  gtgggatat  gaaatctcc  actattgtt  tgttgtttt  9840
tatttctct  ttataattg  catatcttc  tggtaaatt  actttttta  cattaaata  9900
tgttgtttc  ggtaaaaaa  aatttggat  ctaagtaaa  ttttaaata  atttactta  9960
attactact  tttttatgg  ctccatttc  ttaaatacc  gattttcct  tggtatctt  10020
tttttttta  gagagagag  atctccctc  gttgcccag  ctggagtgc  atggtgtga  10080
cttgtctca  tgcaacctc  gccttccag  ttcaagcaa  tcttctgcc  cagcctccg  10140
agtagctgg  attacaagc  tacgccacc  tgcccagct  atttttgta  ttttagtag  10200
gatggggtt  cgccatgtt  gacaggctg  tcttgaact  ctgacctca  atgagtcgc  10260
tgccttagc  tcccaaagt  ctgggattt  gaggcgtga  ccaccacac  tggcccgtg  10320
atcattttt  tttctgcca  caggacatt  tttaatatt  ctcatggtg  gggttctgc  10380
ggtgataaa  ctttgaggt  ttgtatgcc  gaagacatc  ttatttccc  ttctttctg  10440
aagatattt  tccaagtgt  gaatttcag  ttgaaaaat  gttattctc  tgaatacca  10500
aaaagtctt  cttcatttt  acttacctg  attgttttt  atgagaaat  tgatgttat  10560
cttatcttt  tacctctat  catagaatg  ctcgcctcc  tcccactgg  cacttttga  10620
attttctct  tatcattgt  ttttgagca  tttgataat  acatacctt  agttatgtg  10680
cttcatttt  ttgtgctta  catttactg  gtttcttga  ctgtggttt  tagttttaa  10740
taagtttgg  aaattttca  ccattattt  ttcaatttt  ttttctgtc  tctcctctg  10800
cttggtgac  acaactacc  tcatgttac  cagtgtgaa  ctgtcccat  gttcactga  10860
tttcttctc  tattttgta  tcatttttc  gttttattt  gcattttct  tggctattc  10920
tcaaactca  taatctttc  tctgtaata  ttaacctgc  gtgaatccc  ttcagcata  10980
tttttatct  agatatttt  gttttcatc  ctagaagtt  aatttgtct  ttatttata  11040
ctttcatgt  tctacttaa  tttttaaac  tatgcaata  cataacttt  aatattttt  11100
tctgttaat  gtaacattt  agtcagttc  gggttgatt  atactgatt  ttctcctca  11160
tatataagt  gttatttcc  tgcctcttt  cataactca  aatatttta  tgaatgcca  11220
acttggtga  ttgtactcc  gtggattct  ggtattttt  gtattccta  aaatcttct  11280
gagctctgt  ttagaattc  gttaattca  ttggagata  ttttgtcct  ttgtgtttt  11340
ctgtatgaa  tgttaggtg  gtctgaagc  gtgctcagt  tagggacaa  tattcccca  11400
tactgaaac  ggaccttcc  gtatcttct  cccactatt  catgaatta  gagtttttc  11460
agcctgaat  ttgggaaca  gaactacta  ggacgctgt  ttcatgcca  gcacctctg  11520
tgcttcctt  gattctttc  gatggctat  tccccagcc  tggacagtt  cttcagatg  11580
atatgcttg  ctctattga  caggcaaaa  ggaaccctt  tagatcttt  gggttctct  11640
tctctgcag  tctctcttc  ctgttatac  ttcataagg  ttacctcat  tgtttccag  11700
ctctcagca  ctactttcc  ttgttgctt  atgcctgtg  cttgaagga  cattgtttc  11760
tgtatttta  gtgtttctt  ttttattgt  ttaggtgag  ggtaaatcc  attcctgtt  11820
ttcaatttt  gctaaaagt  gaagtcctt  agagtagtt  tgaatgaca  ttttgttca  11880
tacaaaaat  tatacagcc  gtattttct  tcagcagtt  aaaagtatt  tcccactgt  11940
ttctgtctt  cactgattt  gtgattgta  agatgcttt  tacatattc  ctatatctt  12000
ctcagcatt  tgatgtgat  atttatttg  ttgttttag  tatccgatc  gtgttcact  12060
agctagtat  tttttcaga  attgcatct  ttttacttt  ttgttttct  ctggaaatc  12120
gactatcca  gatttagac  tttttgctt  gttgaactt  tatgctcat  tctttattt  12180
ccctccttt  tgttctgtg  ttctgtctc  atactttct  ctgaacaag  ctacagttt  12240
taaattatc  cttctgctt  gtggacttt  ctattgagc  tacctaatg  attttcagt  12300
cagtttatt  tttagtttt  tgtctgttt  tctttttat  aattgtagt  atctcatga  12360
aaaatcttt  tctctcttt  cttaaaaat  ttagtaata  ttattttga  cttagaact  12420
taatatcta  atcacctct  aatctttta  gaataatgg  aatatatct  aacatagac  12480
aataaatta  ccataaaag  ttggcaaac  aatgtcaca  atgtcacaa  tatttatag  12540
taaatttcc  attttttct  tcggttttc  gtcattttt  acccttttt  attagcatg  12600
tttataatt  tttcattaa  tagtccccc  gtagaggct  tggatgatt  ttttctttc  12660
aagaggatg  agttttctt  tgacagggt  aaaacataa  cagatcaat  caatcctat  12720
gatggttgg  tttaggctt  tttaggctt  ttctatcta  ttttgcatt  gttcctaaa  12780
tattacctt  gtgggatct  agctgaaag  acagagtga  ctacctcac  agacttaaa  12840
cctaccctc  atctcccag  accaatcgg  tagtaaatg  tcagctcat  tatatatat  12900
tttttagcc  ttcatatgc  gctttcttt  gagtttcct  gagtctttt  ttgtgcata  12960
accgtttag  agtgacaaa  aacttataa  tatattgca  gcaaatttt  ggacttgtt  13020
atctgtggt  ccctcatct  tgtgatttg  ttctcaatg  taatatgtt  ggcaacccc  13080
aattctaat  tctaccctc  tatttcagt  actgctact  tatgctaac  ctctctttt  13140
ctcttagag  aatgacaaa  gcccttggg  aaaacactt  ggtgaatgt  gcacttacc  13200
tattgttct  ccctcctct  accttttct  ttcaagtcc  gcatttgct  ctctcctgt  13260
tctctaagc  cttgttttg  gtgttttgt  aatctttta  agttgtgta  ttgttttgg  13320
gagaattat  taaattcaa  ctacttctc  gtggccaaa  gagaagtgc  gacattaag  13380
gtgtcttta  agttatcca  gtgattctg  tccacagtt  aaaatcatt  tactatatc  13440
atgtaattg  gaggccagg  gattttaag  gaggctgga  aggtggata  agactagca  13500
aagttggga  tgtagaatt  gtaaaggtt  tgcatttta  tttaatagt  atgggaagc  13560
gtgaaaagt  ttcaagcaa  ggaatgaca  aatcttgtt  acatattga  aagactact  13620
aggatcctc  acggatagt  gattatagg  aagcaagat  gaaatagga  gatatgtta  13680
gaagtactg  agtagtcaa  gtaaagaac  attgtgtct  ggtctagga  aatagcagc  13740
tagatcaaa  aaaattgga  atagcatat  ttttggaaa  catttgtca  gtttgctga  13800
aggttcaat  tgagggatg  aaggtagtg  gtaaataag  atggctctt  aggttttgg  13860
ttgagtcac  gaataaatg  tgataatat  tgctggtga  tagaagagg  gaataaaaa  13920
gcaagtttt  tggaagtgt  ttggatgaa  taagtttga  ctgcctact  gacataaat  13980
cagagggat  aagaataca  ttggatatt  gatttgagc  caggggaga  atcacattt  14040
aagataaaa  tttggggat  agtactctg  acatagtat  taaaggcat  aaaccagat  14100
aaatctttt  gatgatctc  aacatggga  taataataa  aatagttat  tcaaagggc  14160
gttttaaag  taaaagtag  attttataa  tgtaactta  aaactatag  aatgtatat  14220
ttttgttat  ttttctaat  caaccctat  atgtaattt  catagaaat  attaactgc  14280
ggcagggag  agatagaaa  gttatgtat  ttacacatt  tcttggata  tacagacac  14340
cttcagatg  acagatata  agtttttat  atttttaat  cccacattt  atcataaat  14400
tagaattgt  ttaaatatt  gaaacctaa  atattgata  gtcagcatt  ctctgcagg  14460
attatatat  gatatctgt  agggatcct  gatagttga  tgtttggac  tatttagca  14520
ttccaattt  tttcatggg  aatcaaatg  atattaatt  catttttcc  atgctcaag  14580
cactgtgct  ggccatgta  gagatataa  tatgttata  accctgtcc  tacaagaaa  14640
cagtataat  aaggagcaa  gaagtagga  agaataaaa  tagatcata  gtttgtgtg  14700
atgtgtttt  agagaagaa  atactgtca  gttggaagc  attgaaccc  cgccatgaa  14760
gaggtaata  ctgaaatac  tcttgaagg  tggtcagtt  atgaatata  cacaatatt  14820
tgaatgagc  gaatagtaa  aaaattttt  aataggcaa  aaaaagttt  aggaagaag  14880
aaacttaac  cttctttgt  aacagtatt  ctaaattat  atccagaaa  agaatcata  14940
agtccttgt  gaatttagt  aagattatg  gtaatgtag  attgtggca  aaagtaact  15000
acaacgtgc  gattaggtg  ggacttttt  ttggacttt  tggtatgaa  gatgagcct  15060
atttgatta  cagatttct  attttgttg  ctaggtagt  ctagtgaca  tctttgaaa  15120
aggaattca  ttcaagaag  aggatttga  aaagaaaat  agttaagtt  ttgacatga  15180
ttaaaagat  cctttgagg  gccttttgg  aatcaatgt  gatatgtct  atggacact  15240
gcaaatatc  gactctcaa  cttagagtg  tgaggtttc  ctctctctt  ctctctctc  15300
ttctctcac  ttgttcatg  gtgtatggt  tgggtatat  actttgtac  aactcatca  15360
attgtatac  ttaaatata  gcagtttct  tatattact  atacttcaa  atagctatt  15420
tttaaaaaa  caacagagt  aaaaaaagc  ccaaggtta  tattggaac  ttggggaac  15480
tagtgtttc  aatggttaa  tgtttgtga  aaaactcct  gaagattga  aacgagtgt  15540
cagagatgc  gaaagaaaa  cagaacaga  tggtatttg  gaaataaca  gtgtagaaa  15600
tttcaaaag  aatacatga  caatgtaag  gttgtaata  agtagcaaa  tcaagatta  15660
acactggac  ggttaatat  gaggccatt  atgattttg  aagatctat  gcaatgaag  15720
gatagggga  gaaactaga  ttcagtgaa  aaatagtaa  tttaatgaa  ataaaatag  15780
aattataaa  tttttttcc  caagaagtt  tctgatgct  atgggtgtg  gttttcttt  15840
aggggtgat  aaactgtaa  attagattg  ggtgatggt  gcacaacat  gtgaatatg  15900
taaaaaaat  gaattataa  ctttaaatg  gtgagttgt  taatatgta  gttatttca  15960
taaagatgg  acaaaagta  tccaagcgt  aatgagaaa  ataagagaa  cgtgatcaa  16020
attgtaatt  gtttttgtt  taaggatca  ggcctgttt  cagcttgag  caaaagagg  16080
gaagagatt  aagttacag  tgaaacaga  gagatactc  aagaagcat  gttcataga  16140
aagaggcta  gcaatcaag  atttctcag  ttaagagaa  taggcatag  tgtgggcat  16200
gatggaaac  tttttagat  taagggcat  agtaaaagt  atttaaatc  gatcacccc  16260
attttcttg  tgaagtgga  gttgttttc  tgaataaaa  aaggaagag  ggtacaggg  16320
aaagtagca  aaacttgga  attagctga  aagaataaa  taagaccaa  tgcattaat  16380
tcgtattgc  gctgtaaca  attaccaca  acctagtag  ttaaaacaa  ctagatttg  16440
tatctgaga  ttctagagt  caaaagacc  aaatcagtt  cactgtgct  aaattaagg  16500
gtcagctag  cctacatta  tttctgaag  ctctagggg  aaattttgt  cccttgact  16560
tttcagctt  cacaggctg  ctacattcc  ggatcatgg  cctgtcttc  aatttcaaa  16620
tcagtggca  atcaccttc  gtcttctct  acctctgcc  atgcttaca  ctttctgtc  16680
ctccttctg  tcatcttgc  tccctctta  aaggatgtt  gtgattaga  tgggtccat  16740
cagatagca  aagataatc  ccctatata  gaatcctta  gtcaatcac  tctgcagcc  16800
ttttaccat  gaaggtacc  ccttcacag  ttccaggga  tagaatata  atatcttcg  16860
ggggggggc  actatttac  ttacccacc  aggtcaaga  aaaggaatg  gaacaagtg  16920
ttaaaattt  actgaaatt  gagactacc  atatttaat  gtgacaatc  gtttaactg  16980
gtgattgcc  tcatgcaaa  agaacccca  gatctgcct  ttcttttga  aattcttat  17040
gtcatttta  agaatgagc  atctttctg  agcccttgt  tcacgagag  tgaaggaca  17100
tttgtgcag  aaaggaaac  ggtcctggt  cttctatgg  acacagaga  agggttgtt  17160
acagagttg  tgaggtgga  atgcctgtg  agtaaaata  ttttgccct  taattatca  17220
tgaattgcc  ggagtaagt  tacacacag  tatgttgcc  atacacaac  ttgctgttt  17280
ctgagtcca  agttggact  tgttcacta  ataaaatca  aaagagagg  tactgtgtg  17340
ttgaaagat  cacaagctt  aaaaagaca  ttgattcca  ccaatcaca  taagattac  17400
gaaaaaaat  tcgtaagca  agaatcttt  ggttcttta  accagttcc  cataatttc  17460
ccacttata  ttgactggg  gttctttat  cctttgcta  caagcagtt  tcatacacc  17520
ggtgaataa  gtgagattt  gacagttgt  gttgtggag  agcctttct  cagataagg  17580
acagactga  tggtagcag  gacagaact  ttcagtcgc  agtcctcta  acacgtata  17640
tttataaac  actggagga  tgaagtatc  ttttattat  tgttttatc  ctagaatgt  17700
tattctatg  ggtaagaaa  ttatctgtt  tattcacca  ggtgtcttc  gggcctaaa  17760
gaatctgaa  catgctgag  gctgaataa  aatttgtta  aattttgag  tcaaactca  17820
atttgttga  aaacatgag  aaaagaata  aacaaaact  tacaattta  tagcattat  17880
atttttatt  taattactt  gtaaacaaa  acagcctag  aatatgcag  taggttttg  17940
acaaataga  gaaattaaa  cagaaaatt  taaaatgaa  tggatgtgg  agttcaaga  18000
agattaaaa  aaattttaa  acatggtgg  ttatagtta  cgatcttct  aggatccta  18060
tttatataa  ctagcagca  ctccagaga  attggtacc  ccatcccat  gatactatg  18120
gatactata  tgctttctt  cattactca  gttctttct  ttatacata  atatatata  18180
tttattata  ttcaagttc  agggtacat  tgcacaacg  gcaggtttg  tacgtatgt  18240
tacatgtgc  tagttggtg  gctgcaccc  ttaactcgt  atttacatt  ggtatatct  18300
ctaatgcta  ccctctccc  tccccccac  ccacaacag  ccccagtgt  tgatgttcc  18360
cttcctgtg  ccatgtgtt  tcattgttc  attcccacc  ctgagtgag  acaagcggt  18420
tttggtttt  tgtccttgt  atagtttgc  gagaatgat  gtttccagc  tcatccatg  18480
ccctgcaaa  gacatgaac  catcatttt  tatggctgc  tagtattcc  tggtgtata  18540
gtgccacat  ttcttaatc  agtctatca  tgttggaca  ttgggttgg  tccaagtct  18600
gctattgtg  atagtgctg  aataaatgt  cgtgtgcat  tgtctttac  gcagcatga  18660
ttataatcc  ttggtatta  tataatcct  tgggtatat  cccagtaat  ggatggctg  18720
gtcaaatgg  atttctggt  ctagatccc  gaggacttg  cacactgac  tccacaatg  18780
ttgaactag  tttcagtcc  accaacagt  taaaagtgt  cctgtttct  cacaccctc  18840
ccagcacct  ttgtttcct  actttttaa  gatcaccat  ctaactggt  tgagatggt  18900
tctcattgt  gttttgatt  gcgtttctc  gatggccag  gatgatgag  attttttca  18960
gtgtctgtt  gctgcataa  tgtcttctt  tgagaagtg  ctgttcata  ccttcgccc  19020
cttgttgat  gggttgttt  tttttttct  gtaaatttt  ttgagttct  tgtggattc  19080
ggatattag  cctttgtca  atgagtaga  tgcaaaaat  ttctttcat  ctgtaggtt  19140
cctgttcac  ctgatggta  tttctttag  tgtgcagaa  ctctttagt  taattagat  19200
ccatttgtc  attttggct  ttgttgcca  tgcttttgg  gttttagac  tgaagtcct  19260
gcccatgcc  atgtcctga  tggtattgc  taggttttc  tctagggtt  ttatggttt  19320
aggtctaac  tgtaagtct  taatccatc  tgaattaat  tttgtgtaa  gtataagga  19380
gggatccag  ttcagcttt  tacatatgg  tagccagat  tcccagcac  atttattaa  19440
tagggaatc  tttccccat  tcttgtttt  gtcaggttt  tgaaagatc  tatggttgt  19500
gatgtgtgg  attatttct  agggctctg  tgtgttcca  tggtctata  gtctgtttt  19560
gtaccagta  catgctgtt  tggttactg  agccttgta  tatagtttg  agtcaggta  19620
cacattact  atgttcttt  tttcagaaa  aggtcttag  agaaagtaa  aaatttcag  19680
aggcatacc  tgtcacctg  aaagagtag  aacacaaaa  ccacttgag  aattcattt  19740
tctattttt  gtgtgtgta  ttacatttt  ccccttcag  ttccatcta  gccaatcat  19800
gtttctgag  gcccagggt  ctgtggata  gccgcttca  tgcagcctt  acttcttta  19860
tccttgagc  gtagatgat  gggttcaac  tgggagtca  cactgtgga  gagagtgac  19920
gcagcttct  gctctcaga  gaggcactg  attggggtc  gaaatacgt  aggatggca  19980
tgctataga  gagagagac  accaagagg  gggcggaac  ggtggagaa  gcctgatgt  20040
tcccctcag  tgacggcat  ctgaagata  tggagagga  gcggacata  gatcccagg  20100
tcagcaaga  aggaaagag  atgaatggg  cagtggctg  cagagcctc  agttcaaac  20160
cagaggtgt  agcacagac  agtgcaata  caggagggc  gtcacagaa  aagtggttc  20220
ccctgttgg  gccacaaaa  gggaaactg  aaatccatg  ggtttgcac  gtggccact  20280
aaaaccctg  gaaccaaga  gcagctgcc  gctgggcac  ggatatgtg  cccatgatg  20340
ctgggtagt  caaggggtc  cagatggcc  cgtagcggt  atatgccat  gtggccagg  20400
ggcagcact  agcagcccc  aaaaagaag  agaaataca  ctgagtggc  catccaagg  20460
aggagatgg  tgtgtcttg  atgatcagg  tccccagca  cttgggcac  atgaccaag  20520
tgaaaccta  ctccaggaa  gacaagttt  tgaggaaga  gtacatagg  ctttgtagt  20580
cagagtcag  tatagtgac  aggatgatg  ggacattgc  cattaaagt  accaagtaa  20640
tggtcaaga  aaggagaaa  agtagagcc  gaagctcag  ggacagggc  gagaagctc  20700
cgagaacaa  ttcactgac  attgtccag  tttcccaca  cattcttct  cccaggact  20760
cactgggca  tcaaaatct  ggaaggtag  agaaatctc  tatgttatt  ataccttta  20820
tatattctt  taaagggga  ctcctgtgg  ctcattctt  actttcctt  ttagagttg  20880
tgaggatca  acatctata  tctccaaaa  ataataaaa  aaatttgac  attagattc  20940
caatttttg  ggaaagaat  ctacttttc  agacttaat  aacatacta  atatatcta  21000
acatgtcct  atttttctg  tctctgtag  gaatgggca  aatcacagc  ttatgttca  21060
gctcctacc  tatctctct  caataatgg  gctaagaaa  gcaggccaa  catttatga  21120
gagagaggt  gtgacacat  atgaaaagt  gtgaggtca  gcaggtata  tttttgcaa  21180
acaaaaatg  aggaaggag  aaatcaaag  aactgattc  gcaattact  aatgattcc  21240
gaggaggag  tccgaatgt  tctcaatct  aagaagccc  tactcagga  ggtttcact  21300
tattgtgag  atctcaatt  ctacactct  aaaattgca  tgtaaacaa  aagacacac  21360
acatagtca  tgtggctta  cttgatccc  gggatgagt  ttttccaag  ggttgtatg  21420
gtcaagata  catcagaac  atggacaga  tctagatgg  ttaagcatg  actttttca  21480
cagctctct  ggttgactt  tgtcttgac  ctcaagaaa  ttgaagctc  cattttaca  21540
gttaataaa  tacaactta  atatgcaag  gtgactaat  tgaaatccc  tgaaaagga  21600
acaaaagat  tcatcattg  attaataac  aagcttcaa  attgggacc  tgaaattct  21660
tgtgatgac  ataaacata  ggaggaata  aatctgaag  acttagcat  ttgtctgct  21720
tactgtaca  gttccatga  tgttaacca  tataattat  gatataatg  tagacctat  21780
ttctaaatc  tcttatcca  ctcattgcc  aaactcact  tagccccta  tattcaatc  21840
ctaaaataa  ataattaat  cagtaaata  tgattatca  aagataatt  tgtatgcta  21900
gctctgttt  agatactga  gataataca  tagtaaata  aacaagcaa  aatctctgc  21960
ctcataaaa  tcatcatag  gaagacagg  tataaacaa  ttctgttaa  ccaggcacg  22020
aggctcacg  ctgtaatca  agctctttg  gaggtggag  ctggctgat  acctgagat  22080
gggagttca  gaccagcct  accaacata  agaaaccct  tctctacta  aaatacaaa  22140
ttagctcgg  gtggtggtg  atgcctgta  tcccagcta  tcaggaggc  gaggcagga  22200
aatcgctgg  acacgggag  cggaagttg  ggtgagccg  gatcacacc  ttgcactcc  22260
gcatgggca  caagagcaa  attccactc  aaaattaat  aattaatta  ttatgttag  22320
agaaagtat  gtatataag  gcaatggag  agaataaag  agtagagaa  gagacaaac  22380
tttagaggt  gaaagtgtc  gggaaagct  cactgagaa  atgatattt  agtaaagtt  22440
tgagcaggt  caagaagtg  atttaggtt  gtgaaggaa  gagggcggt  aagagaaaa  22500
aatgagaaa  tgctatttt  atttttttg  tgattcata  tcatttaaa  caattcaac  22560
aaggaatca  ttctcttat  aaaacatcc  tgatacctc  tctactttc  tagtaagaa  22620
gagcattta  gaagcagca  ataagcacc  cacaccgtt  taagtgttt  gcatgtatt  22680
tcttatttg  ttctcacaa  acctgaaga  acagatagt  ttataccca  tttacagtc  22740
aggaatctg  gacacagat  agttgagta  ttttttcag  aagtgttgg  atcctgggt  22800
gctgagtcc  agtcaggga  ttggccgac  agtgacact  gcactcact  tttcagaat  22860
ggaataaat  tgagccaca  gtgaggaca  gccagtatc  agtacaggg  ggtagtaag  22920
acaaagcaa  acaatttct  aagatgggc  gaaaatttc  atatattag  aacattgga  22980
aactggaat  ccactttca  agttcttat  ttagaataa  cattattgt  tgtatttgt  23040
tcatacagt  gatgacatg  tccttgaaa  agaaattgt  ttattcatt  ttttacccc  23100
atgcctaga  aggtagatg  ccagtaaat  gttattgaa  aatttaata  ataatgaag  23160
aaatgtggt  aataatcag  gaaacatct  cacagacac  aagtaagta  agtgagccc  23220
attcataag  aatttagac  aaggcacaa  agaatataa  atagcatca  acaattcac  23280
cggactgaa  caatgataa  agatataaa  gtgcttgtc  gcttcctcc  cctcaaacc  23340
cctctttgt  gatacccca  ttcagtaaa  ggcaccacc  caaagtaca  gccaggaac  23400
gggatataa  cctttaatt  gtgccccaa  tttgattat  tttactcct  aacactaat  23460
cagtgtcac  ttctccagc  ctaccacca  tgcctttag  ttctggatt  attttctct  23520
gcctagagt  tggtaggaa  ctgcttctg  ttcattctc  tcaaaccat  cttggtttg  23580
atgtgatct  tcttatcag  aactgtctt  ccagttgct  tcttaacca  caactctgg  23640
taagtcact  acctgctta  tgtctttca  ttactccgt  tggcccctg  gataaagta  23700
atcctttaa  aaggtcttt  cctgtgatc  ctgcttatt  ttccagttt  aaatcccca  23760
tgtagctga  ttttcagtc  cacaaaaat  ctttgtgtt  cttacacac  tcatagtct  23820
tcagcactc  tgtgtttgt  catgtggca  tcttctgtt  gaatccttt  cctgaaact  23880
tgtacaact  tttctttag  ttttgggtt  ttcttgttt  ctttacttc  aattcttta  23940
ccatactaa  gactacccc  taccccagt  caaattgtc  cagcatcaa  catcattgt  24000
ctaatccaa  cattgttgg  attttcatt  tactgttgt  gtatatttt  aatatctac  24060
gtggcaacc  ccagcctca  tgagctgcc  gcctgggca  tctacattg  ctctctggg  24120
accaaatgt  gtttctact  atgccttgt  tttaaagtt  catgtattt  gagtctagc  24180
ctaacccta  ccctacttc  ccataatat  tttaatgta  aggtttgca  tacataagc  24240
tttcaggaa  gcctacgtc  tattaaaag  gaaatactt  gcctggcat  gtggcccac  24300
tctgtaatc  cagcccttg  gaggctgag  caggcagat  acttgaggc  aggagctcc  24360
acatggtaa  actgcatct  tactaaaaa  tacaaaaaa  aaaattagt  gggcatggc  24420
tggcacgcc  gtaatccca  ctactcaag  ggctgaggc  tgagaattg  ttgaaccca  24480
aaggcagaa  ttgcagtga  ccaagattg  gccattgca  cccagcagc  tgagtaata  24540
agcagacct  tgtctcaaa  aaaaaaaaa  aaagaaaga  agaaaagaa  agagaaaca  24600
ttgtgttgc  tgcaatggc  cacacttat  atcccagca  tttgagagg  tcaggcaga  24660
ggattgctt  aactcagaa  ttcgatacc  gactgggta  catagcaag  cctcgtctc  24720
actaaaaaa  aatttttaa  tggccaggc  tggtgatgt  cgcctatag  cccagccac  24780
agggagact  aggcaggaa  atggcctga  cccaggtgt  tgaggctac  gtgagccat  24840
attctgcta  cgcagtcca  cctgggtga  agagagaga  accctgtct  aaacacaaa  24900
caaaacacc  gaaacactt  aacaattct  atttttgaa  agttacaga  aagttggag  24960
aagacaaac  tgtaaaaat  agtacatgt  cagtttcta  atgtagtat  tacaaaatt  25020
aacgtattt  ttaataaac  tgaaatggg  gcatacaga  agagtgatt  ctgcttctt  25080
aggaatcac  gtggggtct  gagagatgg  atagatttg  ctaaaataa  agtgaaaaa  25140
aacctttca  gaagagaaa  taaaacacc  agacatcac  aattgctaa  cgtctaatc  25200
ataactcaa  tttcaatga  atgcacacc  ttcctctga  ttgatcatc  gtttctttc  25260
tattcttca  aatttattt  attcaaatt  aaatttcat  gagttttta  aaaatatta  25320
ataatcgaa  ttctaaata  ttcatgaga  atgttattg  tgagttgtg  ggaaacaaa  25380
acctcataa  ttgctggtg  gagcataaa  tggtgcaat  agttcagag  ggagctaga  25440
agacaatca  tatatatag  aacattatg  atgtattta  cttttgccc  agaaactca  25500
tttctagat  tctatttgt  aggtacact  gcaaaaata  aaaaacaga  atatggata  25560
gtccattat  tacagcatg  tttgtagta  taaaagact  gctaaataa  ttagggcac  25620
tctacaaat  gagtactac  agattataa  aaggagaaa  cttgtggtt  aagaagact  25680
attctggag  tttgttctc  tcaaagcaa  gctatgact  aaatttacg  tattacttc  25740
acaaaacat  agaacttga  tatggaata  agatcttag  gaagctcag  ttgtttttc  25800
tgggaagaa  ctagtgtga  ggaaataat  attggggtt  taaaggcat  tgcatgtga  25860
cttttgatc  actctcata  atgcatact  cataccagt  agcttaaaa  aactaacac  25920
gcttaaggg  atgagaatg  agtaagatg  tgaggagag  tatgtgttg  gaaagatca  25980
gagattttc  gtcatgaat  tagagtcag  tctgcccag  agaggaaaa  tgacaagat  26040
atttttatt  ggttttacc  tctgttact  tgtgtgccc  catgttata  tgactagca  26100
tttcatatt  tgcacaatg  acgtcacac  gaaatataa  caccggcca  gcgcggtgg  26160
tcacgcctg  aatcccagc  ctttgggag  ccgaggcgg  tggatcacg  ggtcaggag  26220
tcgagacca  cctggctaa  acggtgaaa  cctgtctct  ctaaaaaaa  acaaaaaat  26280
agccgggca  ggtggcggg  atctgtagt  ccagctact  gggaggctg  ggcaggaga  26340
cagcgtgaa  ccaggaggc  gagcttgca  tgagcagag  tgcgccact  cactccagc  26400
tgggggaca  agcgagact  cgtctcaaa  aaaaaaaaa  aaaagaaat  taacacctg  26460
aaatagttg  ccacagaag  gctgtcata  cagttgaaa  aaggaaaac  atgtaagtc  26520
acaatgggc  ggcagagga  ttttcatag  tggtggtgc  aggtcgaaa  tacttctct  26580
ctcctttct  tccactcag  tttccaaaa  ccatttcag  aacaggact  catcttatt  26640
gagatgtgg  aagatgcag  gaggaatct  aaatctggg  ctgattgtt  ctcatccag  26700
aaaatgtag  cttacttcc  aaggtctat  ggatacagt  tctgagggc  agggcctta  26760
agaccgtcc  gctgagggc  ttcttcacc  cgttatttc  caggctgta  ataatgggg  26820
tcaacatgg  agtcataac  gtgtaggac  atgatagca  cttcttgcc  tcaggtgaa  26880
tatttgatt  aggccggaa  taggtgagg  ttaatgata  atagaaaag  gagacaaca  26940
ggaggtgtg  ggaacatgt  gaaaaggct  tattcttcc  tttagctga  gggatcttg  27000
ggatggcag  agcaatgtg  gtataggaa  acaagatca  caagcaggg  atcatgacc  27060
ccagaatgg  tccgacgat  gcgtagatc  caaagagtg  tgtgtctgc  cagaccagc  27120
tcagcacag  tgggctgtc  cagaagaag  ggttcacct  gttggtgcc  cagaatgga  27180
aactgaaga  ccatgtggt  tgcacagta  ctacaggaa  gcctgggaa  caggaggta  27240
cagccagtt  ggcacgagt  ctttggttc  tgatgactg  gtagtgcaa  ggactgcag  27300
tggccacat  gcggtcata  gccatggta  ccaggagga  gcattcagc  actccaaag  27360
agaagaaga  atacatctg  gtggcacag  caaggaagg  gatggttgt  tcctgggca  27420
gcagggtcc  cagcatttt  ggcacaatg  ctaggttga  gccaatctc  aggaaagat  27480
agtttctga  gaagaagta  atggggctg  gtagcatgg  gtcagctag  gtaaccaga  27540
tgatgaggc  gtttcccat  agggtgacc  ggtagatgg  tagaaatgt  agaaagagt  27600
atgactgta  ttcagtagg  agggaagag  agctcatga  gataaactc  cttattctt  27660
tccagtttc  tgtagctat  agtgtgggc  gaagtcccc  actgtggtc  tggagaaag  27720
ttattgatt  gaagtcaga  tctcaattt  tttttcaga  tcgttctta  tgtcaggga  27780
agaggcaag  tcagcacct  aggcagagg  agtgccttg  gttgtctaa  aataaaaca  27840
aataaatag  agccagagc  taatctctg  gatgggcct  aatcagctt  tagaggagc  27900
gatatttct  ttcacacct  aagttattc  gaaagggca  gcaaagtca  aatcacaag  27960
ttctgaagg  tccatcaaa  gatacattt  gggagaaag  gatgtttct  aaaacactt  28020
aacttatga  acacaccaa  tgtttataa  ctcgtaaaa  aacacatac  tttaaattt  28080
tcaaaactt  agaaatata  ttataacta  catgaagaa  gcatataat  tgttttcta  28140
tcttcatga  cctttcttg  ctggctaga  tttgagagg  gggtgaaag  ttagcatgt  28200
ttgaggacc  tttacatat  catgttttt  ttcttttat  tctctggtt  atacatgag  28260
aaactgatc  cagataatt  aagaaacac  aatcacatg  aagatcttg  atccaaacc  28320
catctattg  attacaaaa  ccttcagat  tttactaaa  catgctttg  tggactgtc  28380
tgccttatc  gatgactaa  ttattaatt  gtaggagaa  tagaattgg  atttctgca  28440
aatcacagt  aagacagac  aagataagc  cgagaacca  catcattag  attaagatg  28500
ttaggagat  tcctagaca  aactgaatc  caattttgt  ttactggtt  ctaatttgc  28560
gttggttat  tagaggctc  tcttattgt  ttcgtaatc  agaatattg  agtctagtg  28620
agaaatggt  atattaagc  ggaaaatga  attgagagg  tgggataaa  aaaaaaaga  28680
atgaatgtg  ttagcaaac  atggttaaa  aaaattaat  ataaaaatt  aaaacttta  28740
taggaacag  aaaaaccag  actgacaca  agtaaaaga  aaacaaaga  atggtcagt  28800
ttttggata  attacatta  tagacttat  ttacatgct  agaattttg  actttattt  28860
atagatgag  agattcacc  gaatatttg  agctgcaga  tgacattgt  ataatgcta  28920
ttagaagga  cactctgac  ttgttgata  aatgggata  agaagggat  aaaagctgt  28980
ggcctcgga  caagaagac  aggtggtat  tctataatt  ccctccgtc  ttacgcaca  29040
tccattttc  agcagcaga  aacttattt  aaagaggct  aatattagt  aggtcttgg  29100
gaataattt  aacttcaag  ttatgttta  aattccaga  aatctatga  ggaaaaaac  29160
ccattctta  aaaagaatt  taatcaaac  gatctaaga  ttctcagaa  tgctaaaca  29220
taaatgaag  aatgtctac  gtttttagc  cggtttcag  aaaacaaat  taagtttaa  29280
aaataataa  agaaccaat  atgaaaaga  agatcatct  aactagaaa  tctttcact  29340
taggccagg  gtggtggct  atgcctgta  tcccaggac  ttgggagcc  gaggcaggt  29400
gatcacttg  gcctaggag  ttgagacca  cctcagcaa  gtggcgaaa  cccatctct  29460
caaaaaatg  agaaaatat  cagttgtgg  ggcatatgc  tgttgtcct  gctactcag  29520
aggctgagg  gggaggatc  ccagagctc  ggaggttga  gctacattg  gctgtgatt  29580
tgccactgc  ctccagcct  ggtgacaga  tgagactca  tctcaacaa  aaagaaaaa  29640
aaagtaaag  aaaaaatag  aactctctt  ctgtcattc  aaggcaagc  agcccataa  29700
taaacagaa  aggttatgg  agatatgaa  acaaaacac  ttaggttaa  gagatgaaa  29760
ccaagatat  aaatcaatt  tttcccttt  caaaaacaa  agtctgaaa  gaagttgaa  29820
gacattaaa  tgtctttat  acttactct  aacaaagcc  tataaaata  tgaatatcg  29880
ggccaggca  ggtggctca  gcctgtaat  ccagcactt  gggaggcca  ggcaggagg  29940
tcacttgag  ccaggagtt  gaaaacagc  tggccaaca  gctgaaaca  cctctctac  30000
aaaaataca  aaattagct  gccgtggtg  cacatggct  taatctcag  tacttggga  30060
gctgaggca  gagaattgc  tgaactggg  aggcagagg  tgcagtgag  caagactgc  30120
ccgctgcat  ctagcctgg  tgacagaag  agactctgt  ttaataata  taataataa  30180
atagaatat  gaataagta  tcatgaaaa  gacagtgtg  ggccagaaa  gaccacctg  30240
gggacaaaa  aaagccatg  ttattgaag  taaaccttg  ggagcaaaa  gccagaaac  30300
taagaaaac  gagtcaatt  gaatacaaa  ttgaaaaat  acacccaag  tactgggaa  30360
aattatgaa  acataacaa  tataagagg  ataatgaag  aaaatacaa  aaataaaat  30420
actataaca  gtattccag  atgacagaa  gaatggaga  gggtagaaa  aatatccaa  30480
gaagtacca  aggaagaat  aatgtctct  atctaatgg  agagatgac  ttttgaacc  30540
aaagaatcc  taagtatga  agaaaattt  aatatattc  cacaaacat  tttttattt  30600
actgaaaga  tttttttta  ttctgaaaa  agagaaaag  tctgataag  aaccaaact  30660
gaaaatgat  aaaacaaaa  aaaacaaaa  aaaaatacc  cctataaac  acaaccaaa  30720
aaaaaaata  agtattcac  attagggaa  tgcatatat  cttataaag  ccccaatga  30780
atatcacta  acacatata  gaatgggtt  aaaaaaaag  gacaacacc  aatgctggt  30840
aggatttga  gaattggat  attcataca  tgctcatga  aatgtaaat  gtatcagag  30900
tgttcaatc  tttggcttc  ctgggccac  tgggaagaa  aattggctg  taagctaaa  30960
ttaaaaaaa  agaaatctc  taaaggttt  agaaagttt  caaatttgt  ttgggccac  31020
tgcaaagcc  tcctggtct  catgcagcc  gcagggttg  acaagcttg  tatagccac  31080
gcagaaaac  gtttgacag  tctttaaaa  aactaagca  gtaactgtg  tacaaccag  31140
aattgtacc  ttgggtatt  atccctgag  aatgaagac  atgttcata  aaaaacatg  31200
atattcctc  gtgctgtat  cataatagc  tcaaattgt  aaaaaccca  atgatgaaa  31260
aaattatga  gcatttata  cttagtaaa  tcagcaata  agaggatga  ctattgata  31320
atgcaataa  atgaatgaa  ttacagata  ttctgagtg  ataaaacag  cacatattt  31380
attattcca  ttacataac  tttctgtaa  gacaaaatt  taggaatgg  aaagagatt  31440
gtgattgcc  gtgactaac  agagggtgg  gacaagagg  aagcaggtc  ggatataaa  31500
gaccaaggt  ggagatttt  ctagcaatg  aatcctctg  tatggaggg  catttggat  31560
tttgcaaat  ctttcatca  tacatgatt  tgttgacag  aatgattat  tctcctgta  31620
aactccata  ttactcaca  aaaaaactg  taaaaagaa  tgctaatga  tttttttaa  31680
tctgctaaa  atagagttg  aataagctt  gaacacatt  tttaaaata  taaaaga  31737



<210> 1219
<211> 315
<212> PRT
<213> Homo sapiens
<308> AAG45205
<400> 1219

Met Met Trp Glu Asn Trp Thr Ile Val Ser Glu Phe Val Leu Val Ser 
  1               5                  10                  15
Phe Ser Ala Leu Ser Thr Glu Leu Gln Ala Leu Leu Phe Leu Leu Phe 
             20                  25                  30
Leu Thr Ile Tyr Leu Val Thr Leu Met Gly Asn Val Leu Ile Ile Leu 
         35                  40                  45
Val Thr Ile Ala Asp Ser Ala Leu Gln Ser Pro Met Tyr Phe Phe Leu 
     50                  55                  60
Arg Asn Leu Ser Phe Leu Glu Ile Gly Phe Asn Leu Val Ile Val Pro 
 65                  70                  75                  80
Lys Met Leu Gly Thr Leu Ile Ile Gln Asp Thr Thr Ile Ser Phe Leu 
                 85                  90                  95
Gly Cys Ala Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Ala Ala Glu 
             100                105                110
Cys Cys Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 
         115                120                125
Asp Pro Leu His Tyr Pro Val Ile Met Gly His Ile Ser Cys Ala Gln 
     130                135                140
Leu Ala Ala Ala Ser Trp Phe Ser Gly Phe Ser Val Ala Thr Val Gln 
 145                150                155                160
Thr Thr Trp Ile Phe Ser Phe Pro Phe Cys Gly Pro Asn Arg Val Asn 
                 165                170                175
His Phe Phe Cys Asp Ser Pro Pro Val Ile Ala Leu Val Cys Ala Asp 
             180                185                190
Thr Ser Val Phe Glu Leu Glu Ala Leu Thr Ala Thr Val Pro Phe Ile 
         195                200                205
Leu Phe Pro Phe Leu Leu Ile Leu Gly Ser Tyr Val Arg Ile Leu Ser 
     210                215                220
Thr Ile Phe Arg Met Pro Ser Ala Glu Gly Lys His Gln Ala Phe Ser 
 225                230                235                240
Thr Cys Ser Ala His Leu Leu Val Val Ser Leu Phe Tyr Ser Thr Ala 
                 245                250                255
Ile Leu Thr Tyr Phe Arg Pro Gln Ser Ser Ala Ser Ser Glu Ser Lys 
             260                265                270
Lys Leu Leu Ser Leu Ser Ser Thr Val Val Thr Pro Met Leu Asn Pro 
         275                280                285
Ile Ile Tyr Ser Ser Arg Asn Lys Glu Val Lys Ala Ala Leu Lys Arg 
     290                295                300
Leu Ile His Arg Thr Leu Gly Ser Gln Lys Leu 
 305                310                315



<210> 1220
<211> 669
<212> DNA
<213> Rattus norvegicus
<308> AF091563
<400> 1220

ggcaacatg  ctctcctgg  gattggcta  actttttct  tcataccca  gatgctgca  60
agccttgtg  gtgaggccc  agggatctc  cgggaggga  gtgccacac  gatgttttt  120
ttcacactt  ttggtataa  tgagtgctg  ctattggcg  ccatggcct  tgaccgctg  180
atagccata  gctccccac  ccactatgc  acccgaatg  gtcgtgggg  atgtgccca  240
ttggcaatt  tttcatggg  aacaggttg  attgtgggg  tgggacaaa  caattttat  300
ttctcctta  acttttgtg  gccctgtga  atagaccac  tcttctgtg  ccctttcca  360
cttttcctg  gcacttgcc  gtgggagat  catcccaaa  cggaggctg  catctttgt  420
gtagcaatc  tctgtatat  tagtccgtt  ttactgatc  tttattctt  tgtcagaat  480
ctggtcgca  tgctcgtga  gccttcacc  gaggggcgc  ataaagctt  ttccacctg  540
tcgtcccac  tacttgtag  cacactctt  tatggctca  gatccatta  ctacttgag  600
cccaaatct  gccattcac  aggaattga  agactcttg  ctctcttnt  cacagcagt  660
acatccatg  669



<210> 1221
<211> 223
<212> PRT
<213> Rattus norvegicus
<308> AAC64586
<400> 1221

Gly Asn Met Ser Leu Leu Glu Ile Gly Tyr Thr Phe Ser Val Ile Pro 
  1               5                  10                  15
Lys Met Leu Gln Ser Leu Val Ser Glu Ala Arg Gly Ile Ser Arg Glu 
             20                  25                  30
Gly Cys Ala Thr Gln Met Phe Phe Phe Thr Leu Phe Gly Ile Ser Glu 
         35                  40                  45
Cys Cys Leu Leu Ala Ala Met Ala Phe Asp Arg Cys Ile Ala Ile Cys 
     50                  55                  60
Ser Pro Leu His Tyr Ala Thr Arg Met Ser Arg Gly Val Cys Ala His 
 65                  70                  75                  80
Leu Ala Ile Val Ser Trp Gly Thr Gly Cys Ile Val Gly Leu Gly Gln 
                 85                  90                  95
Thr Asn Phe Ile Phe Ser Leu Asn Phe Cys Gly Pro Cys Glu Ile Asp 
             100                105                110
His Phe Phe Cys Asp Pro Phe Gln Leu Phe Leu Gly Thr Cys Leu Trp 
         115                120                125
Glu Ile His Pro Lys Thr Glu Ala Ala Ile Phe Val Val Ala Ile Leu 
     130                135                140
Cys Ile Ser Ser Pro Phe Leu Leu Ile Ile Tyr Ser Tyr Val Arg Ile 
 145                150                155                160
Leu Val Ala Val Leu Val Met Pro Ser Pro Glu Gly Arg His Lys Ala 
                 165                170                175
Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Thr Leu Phe Tyr Gly 
             180                185                190
Ser Gly Ser Ile Asn Tyr Leu Arg Pro Lys Ser Ser His Ser Pro Gly 
         195                200                205
Ile Asp Arg Leu Leu Ala Leu Xaa Tyr Thr Ala Val Thr Ser Met 
     210                215                220



<210> 1222
<211> 31737
<212> DNA
<213> Homo sapiens
<308> AF321237
<400> 1222

ctgagctga  ccaaatccc  gagcctcta  gaactaacc  gatagcacc  tccaccaga  60
ggacggcaa  tcaaaatgt  gcaatgttt  aattacctg  attctcgaa  tttattttt  120
tatcagctg  tttgataat  cactatttt  ctctttaga  gcaattctc  attagtttg  180
tgtgattga  tatatagat  ccttaaacc  atattggct  tgaatctat  atattccaa  240
gaccactgt  ggcactggg  atgaaacaa  ttggcccct  ccctctgga  ttctttagt  300
ttaggaact  ggttttcag  ctgtatccc  agtctttag  atatgcttg  tacacagta  360
ttgctcaaa  aataagatt  attgaatat  caaagtatg  tgggtgccc  aggaaagta  420
tgatacctt  atttagtgg  catgtcttt  agtagaggg  ctatgcgga  caaaaaaca  480
tggggtgta  aaatgcagt  tgttctagt  agttggtat  ggataaggc  ggtaaggtt  540
cctgcagat  gatacggga  ggtggaatt  atctatatt  agtgtgggg  cgtaagtaa  600
catcaagca  agatgtaat  attcataat  atgttttat  tatcagtta  tgaatgagt  660
gatttccct  gaaataaag  taggcactt  tataactgc  aggcactac  gtttttaga  720
attggcagc  tctatcaaa  gtaaagata  gcctaccct  atatattcc  tcttggata  780
agctcgtat  tagcaattc  aatgtttgt  gtttaccct  acaggtata  tggtaacag  840
gaaaaacaa  atatgtata  gaatgttca  aacataatt  tttgtggta  cataaattg  900
ccccaatat  aatgttcat  aataagaga  tagttaact  agttttggt  taactgtag  960
ttaactgta  ttaaactgt  gtgtggaat  taatgaaat  aatagcaag  cataggtat  1020
gctatatat  ttggtcaag  agtgtctcc  agataatag  gattgttgg  aaaattaag  1080
cattaaatc  tatgttaac  acaaaagtg  gcatactca  gtacataca  atatgcata  1140
ttgaattaa  agacatctg  aaagatgta  accaacctg  gatctatgg  tactaatgg  1200
aagggtatt  ggcttgagg  tgtttggaa  gagacttac  attaccata  atttgggcg  1260
tgcatgttg  acacaccac  caacttacc  tttaaagtg  ataattcaa  ggcttttag  1320
atattcaca  agttatgca  ccatcacca  aatcaattt  agaactttt  cgttactcc  1380
aaaagaaac  atacattcc  tagtcatca  catccagtc  tcctataac  ccagcccta  1440
gcaacaacc  atctacttt  tttctctat  gatttgcct  ttcttgaca  ttaatataa  1500
tgaaatcat  caatatgtc  tcctttgtg  ctacttttt  cacttaata  aatgttttt  1560
acgtttatt  atgttgtac  atgttcaat  ctttatatg  atatatcac  gtttttttt  1620
tttgtttgt  tgtttgttt  tttttgagg  ggggtctct  tctctcaca  ggactgaag  1680
gcagtggag  gatctcagc  cactgcaac  tctgcctac  ctgttcaaa  gattcttct  1740
cctcagcct  ccaactatt  gggactata  gcatgtgcc  tgatgccca  ctaattttt  1800
tatttttag  agagacggg  tttcaccac  ttggccagg  tggcctcga  ctcctgacc  1860
taagtgata  acctgcctt  gtctctcaa  gtactggga  tacaggcgt  agccaccac  1920
cccagctga  atatcacct  ttctttata  attcaaaga  atttcactt  ttgtctttg  1980
atcactgca  tttttgagt  ttatgaata  tgttgccat  aacattcat  tataagttt  2040
tgtgtgcaa  atatgcttt  agttctctt  ggtatatac  tactggtgg  gtggctgat  2100
catatggta  cctgctagc  atcctagta  gtgtaaagt  gtatgctat  gtggttttg  2160
tttgcattt  ctttatggc  aatgacatt  aacatattt  catgtgcct  ctggccatt  2220
gcatacctc  tctggaaac  atgtctatt  agattcttt  cccagttat  aattatatt  2280
ttggccttt  tattaccag  ttatgtttc  tatatattc  aaatataag  cccttatca  2340
atacagaat  tgcaaaaat  ttctcccac  ctgtgggtt  tcttttcac  tccttaatg  2400
tgtcttttg  agcacaaac  tttttaatt  tgatgatgt  caatttatt  atttttttc  2460
tttgttctg  aaaatatat  tttgatgta  atttaaaat  caattaagc  aacaaaatg  2520
taaaattaa  taacttatc  tcaaaactg  ggaggaata  agagttcct  ttaaggatt  2580
ggtaagagg  ttttatcct  tcaaagatt  tagagtttg  tggcactgg  ttttatttt  2640
ccattgaat  aacatccac  cctccattt  cctgatata  tggtaatat  gtgtaacca  2700
tacatttat  tgatttgat  tgagactgt  tttgttttg  cagattttc  tagatgtgt  2760
aaagaggag  ataacataa  gaataatct  tattttgag  taaaaaaga  ccttttaag  2820
aattaatct  tacattgta  agtaaaaca  taaggtgaa  ttgttttca  gcttcttcc  2880
ctggtggtt  aaataaaag  ggagaagag  aaagaaatt  ggtcaaact  ttcccagat  2940
ggttgttag  ggtaacttt  gcccaggac  gctacattc  tgtctggag  aaagatgtt  3000
caggagaaa  cccaggaag  gaggaaagg  gtgtagagt  catggctta  cagtagtgg  3060
caaaggtgg  agggttata  attggattt  gtcatacag  tgatgcatg  tggactgag  3120
tgtttgctt  aggccttct  cctgcaaag  gagcaggga  caatgctaa  aatctaaag  3180
accaaacag  taagtagaa  tgcaaaggg  ccttcctcc  aatgccaaa  tccaacttt  3240
gtctgaaga  cagttagga  ttgaaatct  tcatttctt  gactcacag  ccaatccag  3300
tgctgagac  ctgttacta  attatgtag  gtgtaatta  gtctttttt  tttttttaa  3360
aaatctcct  gggattcct  taacccaag  gagttctgc  acttggagt  aaatgttac  3420
tctttattt  tattttccc  taactgaaa  ttgatgttt  cttccaatt  gaatgcaag  3480
aaccaaccc  caccaatat  agaagtatt  atgactttg  cagcagtag  aattataag  3540
atttttata  tgtattgca  ttgttggag  gatctccaa  tatttaaac  catcattat  3600
ttgaaatga  gatggttat  agacccacc  ctacatttc  aaattttag  gtattaata  3660
agaagcaca  atattgctg  ttacaaatc  gttttctaa  attatttcg  taactgtat  3720
ttgatataa  tggtttcct  agtaatcct  tacatttta  ttgatgtat  taaaacgtt  3780
ttctgagat  ctttcacca  acagttaaa  gattgatag  ccaacccgt  tataggatc  3840
taaacttta  actttaaag  aaatttatt  cccttcttt  tggaacagc  ccacaaaat  3900
ggattatta  ttcaaatct  tctagggat  ttggcaaaa  ttctaaatg  ctctgctta  3960
ctatgtgat  aaattatta  ttgtttaat  aattatggt  atttatgaa  tgaagttct  4020
tgctatgtc  tgtaaagga  acagaggtg  aaaagacat  gaaactatt  tcaaaggaa  4080
ttttacttt  gcgggggga  tggacagat  atgcatata  tttttagca  agagagctg  4140
ggagtagtg  tgtttgggc  gagtatgaa  ctagtcacg  tggtggctt  aaatgaaaa  4200
tctgttttg  tggtgtgtc  gttatgttg  aagttcatt  acagttgag  ctgaacaga  4260
ctcaagctg  ggcttcaga  aggattccc  agggtatcc  gagttaatc  ttggtttcc  4320
agctcctgt  agacaggtt  gtttcttaa  taaaacata  cagtacttt  gctctttct  4380
atttcttat  ccttcgtgt  tgtcctttc  cggaaaata  aacagaaaa  tatattatc  4440
taagcgggg  agaggagat  tgacaagag  acttacgac  caggggttt  agttaagaa  4500
aaacagaaa  taaatggca  gactttata  atgaactca  tctgtattt  atattgtat  4560
attaaaagt  tggtattca  agtgagaaa  ataatttta  aaatctatt  ttgccagat  4620
acaccaaca  tgaatgcaa  atcttttaa  gtttgtttt  caacactga  aatgttcca  4680
tgaaagaaa  atgatcatc  tatgaaggg  gttcttgaa  ttttcagta  aaattgggg  4740
agttcctaa  cctgcactt  tgaattata  aattttata  gtatgcctg  ctatggtta  4800
cacatagtg  cttcttact  aaaaggaca  caaactatg  gacagataa  tcagacaca  4860
gtgacagaa  tcctccttc  gggactctc  gatgggcca  acaccgagc  gctgctatt  4920
atcgtatta  tgggtgtct  cctggtcac  gtgcttgga  atctgcttc  aatctccct  4980
gttcatgtt  actcccaac  tcacacacc  atgtatttt  ttctctgca  cttgtctct  5040
gctgacctc  gtttctcta  caacatagt  cctcaggca  tagtccacc  gctttccag  5100
aagaaggtc  ttgcattca  actttgcgc  gctcgactt  tctttttcc  catttttgg  5160
tgtacccag  gcgcccttc  tgcagtgat  tcctatgat  gctatgttg  aatctgcaa  5220
cctctgcgt  accctaaca  catgacctg  aaagtgtgt  tccagctgg  aacaggatc  5280
tggaccagt  gcattctgg  gtctgtggt  gacaccacc  tcacactga  gctacccta  5340
cgaggcagt  acagcattg  tcatttctt  tgtgaggcc  ctgcactat  gatcttagc  5400
tccacagac  cccatgcat  agagatggc  atttttctt  cgggggttg  gattctcct  5460
atacctgtt  ttctgattc  ggtatccta  ggccgtatc  tagtaactg  ggtcaagat  5520
aagtcaact  tggggagtc  caaggcatt  tctacctgt  gctcccacc  catggtggt  5580
atacttttt  atggatcag  aattatcac  tacatgaca  ccaagtctt  caaacagca  5640
gaaaaatcg  tgtctgttt  ctatgcaat  gtgactccc  tgcttaatc  cctcatcta  5700
agcctgaga  acaaggatg  gaaggcagc  ctgaggaaa  tagccacaa  gaatttccc  5760
tgaaggctt  gaatctcac  ctgacagtg  gctcagaga  ccttttggc  tcctacttc  5820
aagacttgc  gggaagaca  ggaatcaac  caggtggat  ggattttta  aaatgtaca  5880
tggcacact  ggtttctca  gtcacctgc  tggccccct  ccaagttgt  ctttccttc  5940
ttttcctcc  ttccttttc  ttccttact  ttctaaagc  ttttaataa  ctttctcct  6000
ctttgaaaa  aaaagtaca  atacaccat  gaatactat  cagccacag  atagaatga  6060
atcatgtca  tcgcagaaa  atagatgca  cttgaaacc  ttatcctaa  tgaactagc  6120
caaaaacag  aaaccaaat  cttcatgtt  tcactcata  gtaggaact  aacattggg  6180
acatatgaa  acaaaggtg  gaacaatag  cattgggga  tactagatt  tgggaggga  6240
ggggaaggg  taaaaaaac  acctattac  tactcacta  ctgggtgat  gattcattt  6300
tactccgta  ctcagcatc  catgatata  ctctgtaac  aacctgcgt  tgtaccctc  6360
attttaaaa  aaaagttga  aagaagaaa  aatgcacat  agatttcaa  ttttcacac  6420
tatatgaaa  tagaattta  atcatgtca  tagtaattt  atatggatg  catgacaat  6480
aaataatat  ttaatatat  ggataaaat  aacttatat  attaaagaa  acttgctgg  6540
tagccctct  ctttgtgaa  ctaaaatat  gtaagactt  aagtgatgg  tatggtaat  6600
accctgatt  gattattat  caatgtttc  atgcattga  acatcacac  gtattccca  6660
actatatat  attatgtca  ttgtaaatt  aaaattaat  aaaaatatg  taagattct  6720
attcttggg  cttatccat  gacacaccc  ctatccttc  tcctgcatt  ctttcatag  6780
aggagaagg  caataattc  tggagcaat  ggaaggagg  tatgcttcc  tctggttgg  6840
cctttgaca  ctaagggtt  agaaatccc  cgagaaaca  acatatttt  taagccttg  6900
aaaatctac  tttttaata  tgctgtgta  tatcacctg  ctatttcag  tcttacttc  6960
agtcctttt  cttttggta  ttctgaatc  ctctgcatc  tcaaatgat  aataaatag  7020
cattactga  tcacttact  tgagctagg  gctacatgt  tgttggcat  tgcacctgt  7080
tgtgtgctt  acatgggta  tgaagagca  gggtacaat  aagcagaat  tatgagctc  7140
gctctcctt  tcacactct  ttagaaaca  aaggatcat  tttatcagg  tacatcttc  7200
taaagatga  tataggagt  gtggaaacc  gcaagaaat  gtgacacat  ccaagaata  7260
tgacacata  caagagtga  aagctgtaa  taacgataa  cctgaatga  caagaggag  7320
gaactagaa  ctggagagg  tagaaatat  ctaagggca  aaggcagta  ctgtggact  7380
aggctatgt  aaggcaagg  agccatggg  agaaatatt  ctcaagccc  ttttccacc  7440
gccttctga  cccccacta  tgtattcca  ttagaagcc  gggaacaag  agccttttg  7500
tataatcca  aaaagatgt  aaacattct  aagcacata  caagctgaa  aaggataga  7560
ggtagatct  gaaaggtca  ctggtgaag  acacacctt  tgccctcag  atccacttc  7620
ttcagtgat  aattcatat  tctaataca  ggaacacat  aagttccat  aagaactat  7680
tcatagcgg  atgatatca  gtagctcac  cttctactt  ctacataaa  gaatagctc  7740
tgtcatgat  atttatgta  gttgaaaga  gaagagcaa  aaaggcaaa  aattagcag  7800
aaacatagc  attgtagct  ctaatcctg  cccagacat  agttgataa  tatagcttg  7860
tctttcact  ccctttcat  gatttctta  tttctacct  aaactcagc  cactggagt  7920
ttttaacaa  gtgtggcaa  ctaaaactt  ttacctgta  tatttgagt  attgatgat  7980
ctgttcctt  ttttttaac  tttagtttc  cgggtacat  tgcaggttt  ttatatagg  8040
caattgcgt  tcacaaggg  ttggtgtac  gattacttc  tcacccagg  aataagcat  8100
gtacctgat  ggcagttta  tttatattc  cccttctct  accctcaac  ctccagtag  8160
ccacaatat  tgttgttct  ttatttgta  ccatgtgta  tcaatattt  gctccaact  8220
ataagtgag  acacacagt  tttggtttt  tgttcctgt  ttaagatag  ataatagcc  8280
ctagctcca  ttatgttgc  gcaaaagac  tgatctcgg  ctttttcat  gctgtatag  8340
attccatgg  gtatatgta  cacatttcc  gctattgat  ggcatttag  ttgattcca  8400
gcctttgct  tgtgaatag  gctgcgatg  acataaccg  gcacgtgtc  ttatggtag  8460
gtaatttat  ttcctctgg  tatataccc  gtaatggca  tgttgggtc  aatagtagt  8520
ctgttttaa  ttattcaag  aatcaccaa  ctgctttcc  cagtggctg  actaattta  8580
attcccacc  gaaaagtgt  cccttttct  tacaatttt  ccagcatct  ttttgttgt  8640
gttgttttg  ctttttaat  gtagccatt  tgactggtg  gagatggta  ctcattgtg  8700
ttttgattt  cacttctct  atgattagt  atgttgagc  ttttttcat  tgcttattt  8760
ccacttgta  gtcttcttt  gaaaagtgt  tgttcggca  cctatagaa  gggagaaaa  8820
ttttgcaat  tatccatct  acaaaggtt  aatatccag  atctacaag  tccttaaac  8880
aattttcaa  aaaaagcaa  caagcccat  aaaaagtgg  tgaaggata  gaacagaca  8940
ttctcaaaa  aagacattg  tgtggccaa  aaacatatg  aaaaaaaaa  ctcatcatc  9000
ctggtcgtt  gagaaatgc  aatcaaaac  ataatgaga  accatctca  accagtgat  9060
atggtgatt  ttaaaaagt  aggaaacaa  agatgctgt  gtgactgtg  agaaatagg  9120
atgcttttt  gtgggagtg  aaattcact  attcaacca  tgtgttcaa  cattgtgga  9180
gacagtgtg  caattcctc  aggatctag  accagaaat  ccatttgac  cagaaatac  9240
attactagg  atatactca  aggattata  atcattcta  tataaagat  catgcccac  9300
tacgtttat  gcagcactg  tcacaatag  aaagacttg  aaccaaccc  aatgcccat  9360
agtgataga  tggattaag  aaatgtggc  catatacac  atagaatac  atgcagcca  9420
gaaaaagga  gagttcatg  cctttgcag  gacatggat  aagctggaa  ccatcattc  9480
cagcaaact  tcacaggaa  aaaaaacta  acaccgcct  ttctcactc  taagtggga  9540
ttgaacaat  aggacacat  gacacaggg  ggggaacat  acccaccgg  gcctgtcgg  9600
ggatggagg  ctaggggaa  gatagcatt  ggagaaata  ctaatgtag  tgactggtt  9660
atggccaca  caaaccacc  tggcacgtg  atacctatg  aacaaacct  cacgttctg  9720
acatgtatc  cagaactta  tatgtgtgt  tgtgtgtgt  tgtgtgtgt  tgtgtgtgt  9780
tgtgtgtgt  tatagatgt  gtgggatat  gaaatctcc  actattgtt  tgttgtttt  9840
tatttctct  ttataattg  catatcttc  tggtaaatt  actttttta  cattaaata  9900
tgttgtttc  ggtaaaaaa  aatttggat  ctaagtaaa  ttttaaata  atttactta  9960
attactact  tttttatgg  ctccatttc  ttaaatacc  gattttcct  tggtatctt  10020
tttttttta  gagagagag  atctccctc  gttgcccag  ctggagtgc  atggtgtga  10080
cttgtctca  tgcaacctc  gccttccag  ttcaagcaa  tcttctgcc  cagcctccg  10140
agtagctgg  attacaagc  tacgccacc  tgcccagct  atttttgta  ttttagtag  10200
gatggggtt  cgccatgtt  gacaggctg  tcttgaact  ctgacctca  atgagtcgc  10260
tgccttagc  tcccaaagt  ctgggattt  gaggcgtga  ccaccacac  tggcccgtg  10320
atcattttt  tttctgcca  caggacatt  tttaatatt  ctcatggtg  gggttctgc  10380
ggtgataaa  ctttgaggt  ttgtatgcc  gaagacatc  ttatttccc  ttctttctg  10440
aagatattt  tccaagtgt  gaatttcag  ttgaaaaat  gttattctc  tgaatacca  10500
aaaagtctt  cttcatttt  acttacctg  attgttttt  atgagaaat  tgatgttat  10560
cttatcttt  tacctctat  catagaatg  ctcgcctcc  tcccactgg  cacttttga  10620
attttctct  tatcattgt  ttttgagca  tttgataat  acatacctt  agttatgtg  10680
cttcatttt  ttgtgctta  catttactg  gtttcttga  ctgtggttt  tagttttaa  10740
taagtttgg  aaattttca  ccattattt  ttcaatttt  ttttctgtc  tctcctctg  10800
cttggtgac  acaactacc  tcatgttac  cagtgtgaa  ctgtcccat  gttcactga  10860
tttcttctc  tattttgta  tcatttttc  gttttattt  gcattttct  tggctattc  10920
tcaaactca  taatctttc  tctgtaata  ttaacctgc  gtgaatccc  ttcagcata  10980
tttttatct  agatatttt  gttttcatc  ctagaagtt  aatttgtct  ttatttata  11040
ctttcatgt  tctacttaa  tttttaaac  tatgcaata  cataacttt  aatattttt  11100
tctgttaat  gtaacattt  agtcagttc  gggttgatt  atactgatt  ttctcctca  11160
tatataagt  gttatttcc  tgcctcttt  cataactca  aatatttta  tgaatgcca  11220
acttggtga  ttgtactcc  gtggattct  ggtattttt  gtattccta  aaatcttct  11280
gagctctgt  ttagaattc  gttaattca  ttggagata  ttttgtcct  ttgtgtttt  11340
ctgtatgaa  tgttaggtg  gtctgaagc  gtgctcagt  tagggacaa  tattcccca  11400
tactgaaac  ggaccttcc  gtatcttct  cccactatt  catgaatta  gagtttttc  11460
agcctgaat  ttgggaaca  gaactacta  ggacgctgt  ttcatgcca  gcacctctg  11520
tgcttcctt  gattctttc  gatggctat  tccccagcc  tggacagtt  cttcagatg  11580
atatgcttg  ctctattga  caggcaaaa  ggaaccctt  tagatcttt  gggttctct  11640
tctctgcag  tctctcttc  ctgttatac  ttcataagg  ttacctcat  tgtttccag  11700
ctctcagca  ctactttcc  ttgttgctt  atgcctgtg  cttgaagga  cattgtttc  11760
tgtatttta  gtgtttctt  ttttattgt  ttaggtgag  ggtaaatcc  attcctgtt  11820
ttcaatttt  gctaaaagt  gaagtcctt  agagtagtt  tgaatgaca  ttttgttca  11880
tacaaaaat  tatacagcc  gtattttct  tcagcagtt  aaaagtatt  tcccactgt  11940
ttctgtctt  cactgattt  gtgattgta  agatgcttt  tacatattc  ctatatctt  12000
ctcagcatt  tgatgtgat  atttatttg  ttgttttag  tatccgatc  gtgttcact  12060
agctagtat  tttttcaga  attgcatct  ttttacttt  ttgttttct  ctggaaatc  12120
gactatcca  gatttagac  tttttgctt  gttgaactt  tatgctcat  tctttattt  12180
ccctccttt  tgttctgtg  ttctgtctc  atactttct  ctgaacaag  ctacagttt  12240
taaattatc  cttctgctt  gtggacttt  ctattgagc  tacctaatg  attttcagt  12300
cagtttatt  tttagtttt  tgtctgttt  tctttttat  aattgtagt  atctcatga  12360
aaaatcttt  tctctcttt  cttaaaaat  ttagtaata  ttattttga  cttagaact  12420
taatatcta  atcacctct  aatctttta  gaataatgg  aatatatct  aacatagac  12480
aataaatta  ccataaaag  ttggcaaac  aatgtcaca  atgtcacaa  tatttatag  12540
taaatttcc  attttttct  tcggttttc  gtcattttt  acccttttt  attagcatg  12600
tttataatt  tttcattaa  tagtccccc  gtagaggct  tggatgatt  ttttctttc  12660
aagaggatg  agttttctt  tgacagggt  aaaacataa  cagatcaat  caatcctat  12720
gatggttgg  tttaggctt  tttaggctt  ttctatcta  ttttgcatt  gttcctaaa  12780
tattacctt  gtgggatct  agctgaaag  acagagtga  ctacctcac  agacttaaa  12840
cctaccctc  atctcccag  accaatcgg  tagtaaatg  tcagctcat  tatatatat  12900
tttttagcc  ttcatatgc  gctttcttt  gagtttcct  gagtctttt  ttgtgcata  12960
accgtttag  agtgacaaa  aacttataa  tatattgca  gcaaatttt  ggacttgtt  13020
atctgtggt  ccctcatct  tgtgatttg  ttctcaatg  taatatgtt  ggcaacccc  13080
aattctaat  tctaccctc  tatttcagt  actgctact  tatgctaac  ctctctttt  13140
ctcttagag  aatgacaaa  gcccttggg  aaaacactt  ggtgaatgt  gcacttacc  13200
tattgttct  ccctcctct  accttttct  ttcaagtcc  gcatttgct  ctctcctgt  13260
tctctaagc  cttgttttg  gtgttttgt  aatctttta  agttgtgta  ttgttttgg  13320
gagaattat  taaattcaa  ctacttctc  gtggccaaa  gagaagtgc  gacattaag  13380
gtgtcttta  agttatcca  gtgattctg  tccacagtt  aaaatcatt  tactatatc  13440
atgtaattg  gaggccagg  gattttaag  gaggctgga  aggtggata  agactagca  13500
aagttggga  tgtagaatt  gtaaaggtt  tgcatttta  tttaatagt  atgggaagc  13560
gtgaaaagt  ttcaagcaa  ggaatgaca  aatcttgtt  acatattga  aagactact  13620
aggatcctc  acggatagt  gattatagg  aagcaagat  gaaatagga  gatatgtta  13680
gaagtactg  agtagtcaa  gtaaagaac  attgtgtct  ggtctagga  aatagcagc  13740
tagatcaaa  aaaattgga  atagcatat  ttttggaaa  catttgtca  gtttgctga  13800
aggttcaat  tgagggatg  aaggtagtg  gtaaataag  atggctctt  aggttttgg  13860
ttgagtcac  gaataaatg  tgataatat  tgctggtga  tagaagagg  gaataaaaa  13920
gcaagtttt  tggaagtgt  ttggatgaa  taagtttga  ctgcctact  gacataaat  13980
cagagggat  aagaataca  ttggatatt  gatttgagc  caggggaga  atcacattt  14040
aagataaaa  tttggggat  agtactctg  acatagtat  taaaggcat  aaaccagat  14100
aaatctttt  gatgatctc  aacatggga  taataataa  aatagttat  tcaaagggc  14160
gttttaaag  taaaagtag  attttataa  tgtaactta  aaactatag  aatgtatat  14220
ttttgttat  ttttctaat  caaccctat  atgtaattt  catagaaat  attaactgc  14280
ggcagggag  agatagaaa  gttatgtat  ttacacatt  tcttggata  tacagacac  14340
cttcagatg  acagatata  agtttttat  atttttaat  cccacattt  atcataaat  14400
tagaattgt  ttaaatatt  gaaacctaa  atattgata  gtcagcatt  ctctgcagg  14460
attatatat  gatatctgt  agggatcct  gatagttga  tgtttggac  tatttagca  14520
ttccaattt  tttcatggg  aatcaaatg  atattaatt  catttttcc  atgctcaag  14580
cactgtgct  ggccatgta  gagatataa  tatgttata  accctgtcc  tacaagaaa  14640
cagtataat  aaggagcaa  gaagtagga  agaataaaa  tagatcata  gtttgtgtg  14700
atgtgtttt  agagaagaa  atactgtca  gttggaagc  attgaaccc  cgccatgaa  14760
gaggtaata  ctgaaatac  tcttgaagg  tggtcagtt  atgaatata  cacaatatt  14820
tgaatgagc  gaatagtaa  aaaattttt  aataggcaa  aaaaagttt  aggaagaag  14880
aaacttaac  cttctttgt  aacagtatt  ctaaattat  atccagaaa  agaatcata  14940
agtccttgt  gaatttagt  aagattatg  gtaatgtag  attgtggca  aaagtaact  15000
acaacgtgc  gattaggtg  ggacttttt  ttggacttt  tggtatgaa  gatgagcct  15060
atttgatta  cagatttct  attttgttg  ctaggtagt  ctagtgaca  tctttgaaa  15120
aggaattca  ttcaagaag  aggatttga  aaagaaaat  agttaagtt  ttgacatga  15180
ttaaaagat  cctttgagg  gccttttgg  aatcaatgt  gatatgtct  atggacact  15240
gcaaatatc  gactctcaa  cttagagtg  tgaggtttc  ctctctctt  ctctctctc  15300
ttctctcac  ttgttcatg  gtgtatggt  tgggtatat  actttgtac  aactcatca  15360
attgtatac  ttaaatata  gcagtttct  tatattact  atacttcaa  atagctatt  15420
tttaaaaaa  caacagagt  aaaaaaagc  ccaaggtta  tattggaac  ttggggaac  15480
tagtgtttc  aatggttaa  tgtttgtga  aaaactcct  gaagattga  aacgagtgt  15540
cagagatgc  gaaagaaaa  cagaacaga  tggtatttg  gaaataaca  gtgtagaaa  15600
tttcaaaag  aatacatga  caatgtaag  gttgtaata  agtagcaaa  tcaagatta  15660
acactggac  ggttaatat  gaggccatt  atgattttg  aagatctat  gcaatgaag  15720
gatagggga  gaaactaga  ttcagtgaa  aaatagtaa  tttaatgaa  ataaaatag  15780
aattataaa  tttttttcc  caagaagtt  tctgatgct  atgggtgtg  gttttcttt  15840
aggggtgat  aaactgtaa  attagattg  ggtgatggt  gcacaacat  gtgaatatg  15900
taaaaaaat  gaattataa  ctttaaatg  gtgagttgt  taatatgta  gttatttca  15960
taaagatgg  acaaaagta  tccaagcgt  aatgagaaa  ataagagaa  cgtgatcaa  16020
attgtaatt  gtttttgtt  taaggatca  ggcctgttt  cagcttgag  caaaagagg  16080
gaagagatt  aagttacag  tgaaacaga  gagatactc  aagaagcat  gttcataga  16140
aagaggcta  gcaatcaag  atttctcag  ttaagagaa  taggcatag  tgtgggcat  16200
gatggaaac  tttttagat  taagggcat  agtaaaagt  atttaaatc  gatcacccc  16260
attttcttg  tgaagtgga  gttgttttc  tgaataaaa  aaggaagag  ggtacaggg  16320
aaagtagca  aaacttgga  attagctga  aagaataaa  taagaccaa  tgcattaat  16380
tcgtattgc  gctgtaaca  attaccaca  acctagtag  ttaaaacaa  ctagatttg  16440
tatctgaga  ttctagagt  caaaagacc  aaatcagtt  cactgtgct  aaattaagg  16500
gtcagctag  cctacatta  tttctgaag  ctctagggg  aaattttgt  cccttgact  16560
tttcagctt  cacaggctg  ctacattcc  ggatcatgg  cctgtcttc  aatttcaaa  16620
tcagtggca  atcaccttc  gtcttctct  acctctgcc  atgcttaca  ctttctgtc  16680
ctccttctg  tcatcttgc  tccctctta  aaggatgtt  gtgattaga  tgggtccat  16740
cagatagca  aagataatc  ccctatata  gaatcctta  gtcaatcac  tctgcagcc  16800
ttttaccat  gaaggtacc  ccttcacag  ttccaggga  tagaatata  atatcttcg  16860
ggggggggc  actatttac  ttacccacc  aggtcaaga  aaaggaatg  gaacaagtg  16920
ttaaaattt  actgaaatt  gagactacc  atatttaat  gtgacaatc  gtttaactg  16980
gtgattgcc  tcatgcaaa  agaacccca  gatctgcct  ttcttttga  aattcttat  17040
gtcatttta  agaatgagc  atctttctg  agcccttgt  tcacgagag  tgaaggaca  17100
tttgtgcag  aaaggaaac  ggtcctggt  cttctatgg  acacagaga  agggttgtt  17160
acagagttg  tgaggtgga  atgcctgtg  agtaaaata  ttttgccct  taattatca  17220
tgaattgcc  ggagtaagt  tacacacag  tatgttgcc  atacacaac  ttgctgttt  17280
ctgagtcca  agttggact  tgttcacta  ataaaatca  aaagagagg  tactgtgtg  17340
ttgaaagat  cacaagctt  aaaaagaca  ttgattcca  ccaatcaca  taagattac  17400
gaaaaaaat  tcgtaagca  agaatcttt  ggttcttta  accagttcc  cataatttc  17460
ccacttata  ttgactggg  gttctttat  cctttgcta  caagcagtt  tcatacacc  17520
ggtgaataa  gtgagattt  gacagttgt  gttgtggag  agcctttct  cagataagg  17580
acagactga  tggtagcag  gacagaact  ttcagtcgc  agtcctcta  acacgtata  17640
tttataaac  actggagga  tgaagtatc  ttttattat  tgttttatc  ctagaatgt  17700
tattctatg  ggtaagaaa  ttatctgtt  tattcacca  ggtgtcttc  gggcctaaa  17760
gaatctgaa  catgctgag  gctgaataa  aatttgtta  aattttgag  tcaaactca  17820
atttgttga  aaacatgag  aaaagaata  aacaaaact  tacaattta  tagcattat  17880
atttttatt  taattactt  gtaaacaaa  acagcctag  aatatgcag  taggttttg  17940
acaaataga  gaaattaaa  cagaaaatt  taaaatgaa  tggatgtgg  agttcaaga  18000
agattaaaa  aaattttaa  acatggtgg  ttatagtta  cgatcttct  aggatccta  18060
tttatataa  ctagcagca  ctccagaga  attggtacc  ccatcccat  gatactatg  18120
gatactata  tgctttctt  cattactca  gttctttct  ttatacata  atatatata  18180
tttattata  ttcaagttc  agggtacat  tgcacaacg  gcaggtttg  tacgtatgt  18240
tacatgtgc  tagttggtg  gctgcaccc  ttaactcgt  atttacatt  ggtatatct  18300
ctaatgcta  ccctctccc  tccccccac  ccacaacag  ccccagtgt  tgatgttcc  18360
cttcctgtg  ccatgtgtt  tcattgttc  attcccacc  ctgagtgag  acaagcggt  18420
tttggtttt  tgtccttgt  atagtttgc  gagaatgat  gtttccagc  tcatccatg  18480
ccctgcaaa  gacatgaac  catcatttt  tatggctgc  tagtattcc  tggtgtata  18540
gtgccacat  ttcttaatc  agtctatca  tgttggaca  ttgggttgg  tccaagtct  18600
gctattgtg  atagtgctg  aataaatgt  cgtgtgcat  tgtctttac  gcagcatga  18660
ttataatcc  ttggtatta  tataatcct  tgggtatat  cccagtaat  ggatggctg  18720
gtcaaatgg  atttctggt  ctagatccc  gaggacttg  cacactgac  tccacaatg  18780
ttgaactag  tttcagtcc  accaacagt  taaaagtgt  cctgtttct  cacaccctc  18840
ccagcacct  ttgtttcct  actttttaa  gatcaccat  ctaactggt  tgagatggt  18900
tctcattgt  gttttgatt  gcgtttctc  gatggccag  gatgatgag  attttttca  18960
gtgtctgtt  gctgcataa  tgtcttctt  tgagaagtg  ctgttcata  ccttcgccc  19020
cttgttgat  gggttgttt  tttttttct  gtaaatttt  ttgagttct  tgtggattc  19080
ggatattag  cctttgtca  atgagtaga  tgcaaaaat  ttctttcat  ctgtaggtt  19140
cctgttcac  ctgatggta  tttctttag  tgtgcagaa  ctctttagt  taattagat  19200
ccatttgtc  attttggct  ttgttgcca  tgcttttgg  gttttagac  tgaagtcct  19260
gcccatgcc  atgtcctga  tggtattgc  taggttttc  tctagggtt  ttatggttt  19320
aggtctaac  tgtaagtct  taatccatc  tgaattaat  tttgtgtaa  gtataagga  19380
gggatccag  ttcagcttt  tacatatgg  tagccagat  tcccagcac  atttattaa  19440
tagggaatc  tttccccat  tcttgtttt  gtcaggttt  tgaaagatc  tatggttgt  19500
gatgtgtgg  attatttct  agggctctg  tgtgttcca  tggtctata  gtctgtttt  19560
gtaccagta  catgctgtt  tggttactg  agccttgta  tatagtttg  agtcaggta  19620
cacattact  atgttcttt  tttcagaaa  aggtcttag  agaaagtaa  aaatttcag  19680
aggcatacc  tgtcacctg  aaagagtag  aacacaaaa  ccacttgag  aattcattt  19740
tctattttt  gtgtgtgta  ttacatttt  ccccttcag  ttccatcta  gccaatcat  19800
gtttctgag  gcccagggt  ctgtggata  gccgcttca  tgcagcctt  acttcttta  19860
tccttgagc  gtagatgat  gggttcaac  tgggagtca  cactgtgga  gagagtgac  19920
gcagcttct  gctctcaga  gaggcactg  attggggtc  gaaatacgt  aggatggca  19980
tgctataga  gagagagac  accaagagg  gggcggaac  ggtggagaa  gcctgatgt  20040
tcccctcag  tgacggcat  ctgaagata  tggagagga  gcggacata  gatcccagg  20100
tcagcaaga  aggaaagag  atgaatggg  cagtggctg  cagagcctc  agttcaaac  20160
cagaggtgt  agcacagac  agtgcaata  caggagggc  gtcacagaa  aagtggttc  20220
ccctgttgg  gccacaaaa  gggaaactg  aaatccatg  ggtttgcac  gtggccact  20280
aaaaccctg  gaaccaaga  gcagctgcc  gctgggcac  ggatatgtg  cccatgatg  20340
ctgggtagt  caaggggtc  cagatggcc  cgtagcggt  atatgccat  gtggccagg  20400
ggcagcact  agcagcccc  aaaaagaag  agaaataca  ctgagtggc  catccaagg  20460
aggagatgg  tgtgtcttg  atgatcagg  tccccagca  cttgggcac  atgaccaag  20520
tgaaaccta  ctccaggaa  gacaagttt  tgaggaaga  gtacatagg  ctttgtagt  20580
cagagtcag  tatagtgac  aggatgatg  ggacattgc  cattaaagt  accaagtaa  20640
tggtcaaga  aaggagaaa  agtagagcc  gaagctcag  ggacagggc  gagaagctc  20700
cgagaacaa  ttcactgac  attgtccag  tttcccaca  cattcttct  cccaggact  20760
cactgggca  tcaaaatct  ggaaggtag  agaaatctc  tatgttatt  ataccttta  20820
tatattctt  taaagggga  ctcctgtgg  ctcattctt  actttcctt  ttagagttg  20880
tgaggatca  acatctata  tctccaaaa  ataataaaa  aaatttgac  attagattc  20940
caatttttg  ggaaagaat  ctacttttc  agacttaat  aacatacta  atatatcta  21000
acatgtcct  atttttctg  tctctgtag  gaatgggca  aatcacagc  ttatgttca  21060
gctcctacc  tatctctct  caataatgg  gctaagaaa  gcaggccaa  catttatga  21120
gagagaggt  gtgacacat  atgaaaagt  gtgaggtca  gcaggtata  tttttgcaa  21180
acaaaaatg  aggaaggag  aaatcaaag  aactgattc  gcaattact  aatgattcc  21240
gaggaggag  tccgaatgt  tctcaatct  aagaagccc  tactcagga  ggtttcact  21300
tattgtgag  atctcaatt  ctacactct  aaaattgca  tgtaaacaa  aagacacac  21360
acatagtca  tgtggctta  cttgatccc  gggatgagt  ttttccaag  ggttgtatg  21420
gtcaagata  catcagaac  atggacaga  tctagatgg  ttaagcatg  actttttca  21480
cagctctct  ggttgactt  tgtcttgac  ctcaagaaa  ttgaagctc  cattttaca  21540
gttaataaa  tacaactta  atatgcaag  gtgactaat  tgaaatccc  tgaaaagga  21600
acaaaagat  tcatcattg  attaataac  aagcttcaa  attgggacc  tgaaattct  21660
tgtgatgac  ataaacata  ggaggaata  aatctgaag  acttagcat  ttgtctgct  21720
tactgtaca  gttccatga  tgttaacca  tataattat  gatataatg  tagacctat  21780
ttctaaatc  tcttatcca  ctcattgcc  aaactcact  tagccccta  tattcaatc  21840
ctaaaataa  ataattaat  cagtaaata  tgattatca  aagataatt  tgtatgcta  21900
gctctgttt  agatactga  gataataca  tagtaaata  aacaagcaa  aatctctgc  21960
ctcataaaa  tcatcatag  gaagacagg  tataaacaa  ttctgttaa  ccaggcacg  22020
aggctcacg  ctgtaatca  agctctttg  gaggtggag  ctggctgat  acctgagat  22080
gggagttca  gaccagcct  accaacata  agaaaccct  tctctacta  aaatacaaa  22140
ttagctcgg  gtggtggtg  atgcctgta  tcccagcta  tcaggaggc  gaggcagga  22200
aatcgctgg  acacgggag  cggaagttg  ggtgagccg  gatcacacc  ttgcactcc  22260
gcatgggca  caagagcaa  attccactc  aaaattaat  aattaatta  ttatgttag  22320
agaaagtat  gtatataag  gcaatggag  agaataaag  agtagagaa  gagacaaac  22380
tttagaggt  gaaagtgtc  gggaaagct  cactgagaa  atgatattt  agtaaagtt  22440
tgagcaggt  caagaagtg  atttaggtt  gtgaaggaa  gagggcggt  aagagaaaa  22500
aatgagaaa  tgctatttt  atttttttg  tgattcata  tcatttaaa  caattcaac  22560
aaggaatca  ttctcttat  aaaacatcc  tgatacctc  tctactttc  tagtaagaa  22620
gagcattta  gaagcagca  ataagcacc  cacaccgtt  taagtgttt  gcatgtatt  22680
tcttatttg  ttctcacaa  acctgaaga  acagatagt  ttataccca  tttacagtc  22740
aggaatctg  gacacagat  agttgagta  ttttttcag  aagtgttgg  atcctgggt  22800
gctgagtcc  agtcaggga  ttggccgac  agtgacact  gcactcact  tttcagaat  22860
ggaataaat  tgagccaca  gtgaggaca  gccagtatc  agtacaggg  ggtagtaag  22920
acaaagcaa  acaatttct  aagatgggc  gaaaatttc  atatattag  aacattgga  22980
aactggaat  ccactttca  agttcttat  ttagaataa  cattattgt  tgtatttgt  23040
tcatacagt  gatgacatg  tccttgaaa  agaaattgt  ttattcatt  ttttacccc  23100
atgcctaga  aggtagatg  ccagtaaat  gttattgaa  aatttaata  ataatgaag  23160
aaatgtggt  aataatcag  gaaacatct  cacagacac  aagtaagta  agtgagccc  23220
attcataag  aatttagac  aaggcacaa  agaatataa  atagcatca  acaattcac  23280
cggactgaa  caatgataa  agatataaa  gtgcttgtc  gcttcctcc  cctcaaacc  23340
cctctttgt  gatacccca  ttcagtaaa  ggcaccacc  caaagtaca  gccaggaac  23400
gggatataa  cctttaatt  gtgccccaa  tttgattat  tttactcct  aacactaat  23460
cagtgtcac  ttctccagc  ctaccacca  tgcctttag  ttctggatt  attttctct  23520
gcctagagt  tggtaggaa  ctgcttctg  ttcattctc  tcaaaccat  cttggtttg  23580
atgtgatct  tcttatcag  aactgtctt  ccagttgct  tcttaacca  caactctgg  23640
taagtcact  acctgctta  tgtctttca  ttactccgt  tggcccctg  gataaagta  23700
atcctttaa  aaggtcttt  cctgtgatc  ctgcttatt  ttccagttt  aaatcccca  23760
tgtagctga  ttttcagtc  cacaaaaat  ctttgtgtt  cttacacac  tcatagtct  23820
tcagcactc  tgtgtttgt  catgtggca  tcttctgtt  gaatccttt  cctgaaact  23880
tgtacaact  tttctttag  ttttgggtt  ttcttgttt  ctttacttc  aattcttta  23940
ccatactaa  gactacccc  taccccagt  caaattgtc  cagcatcaa  catcattgt  24000
ctaatccaa  cattgttgg  attttcatt  tactgttgt  gtatatttt  aatatctac  24060
gtggcaacc  ccagcctca  tgagctgcc  gcctgggca  tctacattg  ctctctggg  24120
accaaatgt  gtttctact  atgccttgt  tttaaagtt  catgtattt  gagtctagc  24180
ctaacccta  ccctacttc  ccataatat  tttaatgta  aggtttgca  tacataagc  24240
tttcaggaa  gcctacgtc  tattaaaag  gaaatactt  gcctggcat  gtggcccac  24300
tctgtaatc  cagcccttg  gaggctgag  caggcagat  acttgaggc  aggagctcc  24360
acatggtaa  actgcatct  tactaaaaa  tacaaaaaa  aaaattagt  gggcatggc  24420
tggcacgcc  gtaatccca  ctactcaag  ggctgaggc  tgagaattg  ttgaaccca  24480
aaggcagaa  ttgcagtga  ccaagattg  gccattgca  cccagcagc  tgagtaata  24540
agcagacct  tgtctcaaa  aaaaaaaaa  aaagaaaga  agaaaagaa  agagaaaca  24600
ttgtgttgc  tgcaatggc  cacacttat  atcccagca  tttgagagg  tcaggcaga  24660
ggattgctt  aactcagaa  ttcgatacc  gactgggta  catagcaag  cctcgtctc  24720
actaaaaaa  aatttttaa  tggccaggc  tggtgatgt  cgcctatag  cccagccac  24780
agggagact  aggcaggaa  atggcctga  cccaggtgt  tgaggctac  gtgagccat  24840
attctgcta  cgcagtcca  cctgggtga  agagagaga  accctgtct  aaacacaaa  24900
caaaacacc  gaaacactt  aacaattct  atttttgaa  agttacaga  aagttggag  24960
aagacaaac  tgtaaaaat  agtacatgt  cagtttcta  atgtagtat  tacaaaatt  25020
aacgtattt  ttaataaac  tgaaatggg  gcatacaga  agagtgatt  ctgcttctt  25080
aggaatcac  gtggggtct  gagagatgg  atagatttg  ctaaaataa  agtgaaaaa  25140
aacctttca  gaagagaaa  taaaacacc  agacatcac  aattgctaa  cgtctaatc  25200
ataactcaa  tttcaatga  atgcacacc  ttcctctga  ttgatcatc  gtttctttc  25260
tattcttca  aatttattt  attcaaatt  aaatttcat  gagttttta  aaaatatta  25320
ataatcgaa  ttctaaata  ttcatgaga  atgttattg  tgagttgtg  ggaaacaaa  25380
acctcataa  ttgctggtg  gagcataaa  tggtgcaat  agttcagag  ggagctaga  25440
agacaatca  tatatatag  aacattatg  atgtattta  cttttgccc  agaaactca  25500
tttctagat  tctatttgt  aggtacact  gcaaaaata  aaaaacaga  atatggata  25560
gtccattat  tacagcatg  tttgtagta  taaaagact  gctaaataa  ttagggcac  25620
tctacaaat  gagtactac  agattataa  aaggagaaa  cttgtggtt  aagaagact  25680
attctggag  tttgttctc  tcaaagcaa  gctatgact  aaatttacg  tattacttc  25740
acaaaacat  agaacttga  tatggaata  agatcttag  gaagctcag  ttgtttttc  25800
tgggaagaa  ctagtgtga  ggaaataat  attggggtt  taaaggcat  tgcatgtga  25860
cttttgatc  actctcata  atgcatact  cataccagt  agcttaaaa  aactaacac  25920
gcttaaggg  atgagaatg  agtaagatg  tgaggagag  tatgtgttg  gaaagatca  25980
gagattttc  gtcatgaat  tagagtcag  tctgcccag  agaggaaaa  tgacaagat  26040
atttttatt  ggttttacc  tctgttact  tgtgtgccc  catgttata  tgactagca  26100
tttcatatt  tgcacaatg  acgtcacac  gaaatataa  caccggcca  gcgcggtgg  26160
tcacgcctg  aatcccagc  ctttgggag  ccgaggcgg  tggatcacg  ggtcaggag  26220
tcgagacca  cctggctaa  acggtgaaa  cctgtctct  ctaaaaaaa  acaaaaaat  26280
agccgggca  ggtggcggg  atctgtagt  ccagctact  gggaggctg  ggcaggaga  26340
cagcgtgaa  ccaggaggc  gagcttgca  tgagcagag  tgcgccact  cactccagc  26400
tgggggaca  agcgagact  cgtctcaaa  aaaaaaaaa  aaaagaaat  taacacctg  26460
aaatagttg  ccacagaag  gctgtcata  cagttgaaa  aaggaaaac  atgtaagtc  26520
acaatgggc  ggcagagga  ttttcatag  tggtggtgc  aggtcgaaa  tacttctct  26580
ctcctttct  tccactcag  tttccaaaa  ccatttcag  aacaggact  catcttatt  26640
gagatgtgg  aagatgcag  gaggaatct  aaatctggg  ctgattgtt  ctcatccag  26700
aaaatgtag  cttacttcc  aaggtctat  ggatacagt  tctgagggc  agggcctta  26760
agaccgtcc  gctgagggc  ttcttcacc  cgttatttc  caggctgta  ataatgggg  26820
tcaacatgg  agtcataac  gtgtaggac  atgatagca  cttcttgcc  tcaggtgaa  26880
tatttgatt  aggccggaa  taggtgagg  ttaatgata  atagaaaag  gagacaaca  26940
ggaggtgtg  ggaacatgt  gaaaaggct  tattcttcc  tttagctga  gggatcttg  27000
ggatggcag  agcaatgtg  gtataggaa  acaagatca  caagcaggg  atcatgacc  27060
ccagaatgg  tccgacgat  gcgtagatc  caaagagtg  tgtgtctgc  cagaccagc  27120
tcagcacag  tgggctgtc  cagaagaag  ggttcacct  gttggtgcc  cagaatgga  27180
aactgaaga  ccatgtggt  tgcacagta  ctacaggaa  gcctgggaa  caggaggta  27240
cagccagtt  ggcacgagt  ctttggttc  tgatgactg  gtagtgcaa  ggactgcag  27300
tggccacat  gcggtcata  gccatggta  ccaggagga  gcattcagc  actccaaag  27360
agaagaaga  atacatctg  gtggcacag  caaggaagg  gatggttgt  tcctgggca  27420
gcagggtcc  cagcatttt  ggcacaatg  ctaggttga  gccaatctc  aggaaagat  27480
agtttctga  gaagaagta  atggggctg  gtagcatgg  gtcagctag  gtaaccaga  27540
tgatgaggc  gtttcccat  agggtgacc  ggtagatgg  tagaaatgt  agaaagagt  27600
atgactgta  ttcagtagg  agggaagag  agctcatga  gataaactc  cttattctt  27660
tccagtttc  tgtagctat  agtgtgggc  gaagtcccc  actgtggtc  tggagaaag  27720
ttattgatt  gaagtcaga  tctcaattt  tttttcaga  tcgttctta  tgtcaggga  27780
agaggcaag  tcagcacct  aggcagagg  agtgccttg  gttgtctaa  aataaaaca  27840
aataaatag  agccagagc  taatctctg  gatgggcct  aatcagctt  tagaggagc  27900
gatatttct  ttcacacct  aagttattc  gaaagggca  gcaaagtca  aatcacaag  27960
ttctgaagg  tccatcaaa  gatacattt  gggagaaag  gatgtttct  aaaacactt  28020
aacttatga  acacaccaa  tgtttataa  ctcgtaaaa  aacacatac  tttaaattt  28080
tcaaaactt  agaaatata  ttataacta  catgaagaa  gcatataat  tgttttcta  28140
tcttcatga  cctttcttg  ctggctaga  tttgagagg  gggtgaaag  ttagcatgt  28200
ttgaggacc  tttacatat  catgttttt  ttcttttat  tctctggtt  atacatgag  28260
aaactgatc  cagataatt  aagaaacac  aatcacatg  aagatcttg  atccaaacc  28320
catctattg  attacaaaa  ccttcagat  tttactaaa  catgctttg  tggactgtc  28380
tgccttatc  gatgactaa  ttattaatt  gtaggagaa  tagaattgg  atttctgca  28440
aatcacagt  aagacagac  aagataagc  cgagaacca  catcattag  attaagatg  28500
ttaggagat  tcctagaca  aactgaatc  caattttgt  ttactggtt  ctaatttgc  28560
gttggttat  tagaggctc  tcttattgt  ttcgtaatc  agaatattg  agtctagtg  28620
agaaatggt  atattaagc  ggaaaatga  attgagagg  tgggataaa  aaaaaaaga  28680
atgaatgtg  ttagcaaac  atggttaaa  aaaattaat  ataaaaatt  aaaacttta  28740
taggaacag  aaaaaccag  actgacaca  agtaaaaga  aaacaaaga  atggtcagt  28800
ttttggata  attacatta  tagacttat  ttacatgct  agaattttg  actttattt  28860
atagatgag  agattcacc  gaatatttg  agctgcaga  tgacattgt  ataatgcta  28920
ttagaagga  cactctgac  ttgttgata  aatgggata  agaagggat  aaaagctgt  28980
ggcctcgga  caagaagac  aggtggtat  tctataatt  ccctccgtc  ttacgcaca  29040
tccattttc  agcagcaga  aacttattt  aaagaggct  aatattagt  aggtcttgg  29100
gaataattt  aacttcaag  ttatgttta  aattccaga  aatctatga  ggaaaaaac  29160
ccattctta  aaaagaatt  taatcaaac  gatctaaga  ttctcagaa  tgctaaaca  29220
taaatgaag  aatgtctac  gtttttagc  cggtttcag  aaaacaaat  taagtttaa  29280
aaataataa  agaaccaat  atgaaaaga  agatcatct  aactagaaa  tctttcact  29340
taggccagg  gtggtggct  atgcctgta  tcccaggac  ttgggagcc  gaggcaggt  29400
gatcacttg  gcctaggag  ttgagacca  cctcagcaa  gtggcgaaa  cccatctct  29460
caaaaaatg  agaaaatat  cagttgtgg  ggcatatgc  tgttgtcct  gctactcag  29520
aggctgagg  gggaggatc  ccagagctc  ggaggttga  gctacattg  gctgtgatt  29580
tgccactgc  ctccagcct  ggtgacaga  tgagactca  tctcaacaa  aaagaaaaa  29640
aaagtaaag  aaaaaatag  aactctctt  ctgtcattc  aaggcaagc  agcccataa  29700
taaacagaa  aggttatgg  agatatgaa  acaaaacac  ttaggttaa  gagatgaaa  29760
ccaagatat  aaatcaatt  tttcccttt  caaaaacaa  agtctgaaa  gaagttgaa  29820
gacattaaa  tgtctttat  acttactct  aacaaagcc  tataaaata  tgaatatcg  29880
ggccaggca  ggtggctca  gcctgtaat  ccagcactt  gggaggcca  ggcaggagg  29940
tcacttgag  ccaggagtt  gaaaacagc  tggccaaca  gctgaaaca  cctctctac  30000
aaaaataca  aaattagct  gccgtggtg  cacatggct  taatctcag  tacttggga  30060
gctgaggca  gagaattgc  tgaactggg  aggcagagg  tgcagtgag  caagactgc  30120
ccgctgcat  ctagcctgg  tgacagaag  agactctgt  ttaataata  taataataa  30180
atagaatat  gaataagta  tcatgaaaa  gacagtgtg  ggccagaaa  gaccacctg  30240
gggacaaaa  aaagccatg  ttattgaag  taaaccttg  ggagcaaaa  gccagaaac  30300
taagaaaac  gagtcaatt  gaatacaaa  ttgaaaaat  acacccaag  tactgggaa  30360
aattatgaa  acataacaa  tataagagg  ataatgaag  aaaatacaa  aaataaaat  30420
actataaca  gtattccag  atgacagaa  gaatggaga  gggtagaaa  aatatccaa  30480
gaagtacca  aggaagaat  aatgtctct  atctaatgg  agagatgac  ttttgaacc  30540
aaagaatcc  taagtatga  agaaaattt  aatatattc  cacaaacat  tttttattt  30600
actgaaaga  tttttttta  ttctgaaaa  agagaaaag  tctgataag  aaccaaact  30660
gaaaatgat  aaaacaaaa  aaaacaaaa  aaaaatacc  cctataaac  acaaccaaa  30720
aaaaaaata  agtattcac  attagggaa  tgcatatat  cttataaag  ccccaatga  30780
atatcacta  acacatata  gaatgggtt  aaaaaaaag  gacaacacc  aatgctggt  30840
aggatttga  gaattggat  attcataca  tgctcatga  aatgtaaat  gtatcagag  30900
tgttcaatc  tttggcttc  ctgggccac  tgggaagaa  aattggctg  taagctaaa  30960
ttaaaaaaa  agaaatctc  taaaggttt  agaaagttt  caaatttgt  ttgggccac  31020
tgcaaagcc  tcctggtct  catgcagcc  gcagggttg  acaagcttg  tatagccac  31080
gcagaaaac  gtttgacag  tctttaaaa  aactaagca  gtaactgtg  tacaaccag  31140
aattgtacc  ttgggtatt  atccctgag  aatgaagac  atgttcata  aaaaacatg  31200
atattcctc  gtgctgtat  cataatagc  tcaaattgt  aaaaaccca  atgatgaaa  31260
aaattatga  gcatttata  cttagtaaa  tcagcaata  agaggatga  ctattgata  31320
atgcaataa  atgaatgaa  ttacagata  ttctgagtg  ataaaacag  cacatattt  31380
attattcca  ttacataac  tttctgtaa  gacaaaatt  taggaatgg  aaagagatt  31440
gtgattgcc  gtgactaac  agagggtgg  gacaagagg  aagcaggtc  ggatataaa  31500
gaccaaggt  ggagatttt  ctagcaatg  aatcctctg  tatggaggg  catttggat  31560
tttgcaaat  ctttcatca  tacatgatt  tgttgacag  aatgattat  tctcctgta  31620
aactccata  ttactcaca  aaaaaactg  taaaaagaa  tgctaatga  tttttttaa  31680
tctgctaaa  atagagttg  aataagctt  gaacacatt  tttaaaata  taaaaga  31737



<210> 1223
<211> 315
<212> PRT
<213> Homo sapiens
<308> AAG45205
<400> 1223

Met Met Trp Glu Asn Trp Thr Ile Val Ser Glu Phe Val Leu Val Ser 
  1               5                  10                  15
Phe Ser Ala Leu Ser Thr Glu Leu Gln Ala Leu Leu Phe Leu Leu Phe 
             20                  25                  30
Leu Thr Ile Tyr Leu Val Thr Leu Met Gly Asn Val Leu Ile Ile Leu 
         35                  40                  45
Val Thr Ile Ala Asp Ser Ala Leu Gln Ser Pro Met Tyr Phe Phe Leu 
     50                  55                  60
Arg Asn Leu Ser Phe Leu Glu Ile Gly Phe Asn Leu Val Ile Val Pro 
 65                  70                  75                  80
Lys Met Leu Gly Thr Leu Ile Ile Gln Asp Thr Thr Ile Ser Phe Leu 
                 85                  90                  95
Gly Cys Ala Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Ala Ala Glu 
             100                105                110
Cys Cys Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 
         115                120                125
Asp Pro Leu His Tyr Pro Val Ile Met Gly His Ile Ser Cys Ala Gln 
     130                135                140
Leu Ala Ala Ala Ser Trp Phe Ser Gly Phe Ser Val Ala Thr Val Gln 
 145                150                155                160
Thr Thr Trp Ile Phe Ser Phe Pro Phe Cys Gly Pro Asn Arg Val Asn 
                 165                170                175
His Phe Phe Cys Asp Ser Pro Pro Val Ile Ala Leu Val Cys Ala Asp 
             180                185                190
Thr Ser Val Phe Glu Leu Glu Ala Leu Thr Ala Thr Val Pro Phe Ile 
         195                200                205
Leu Phe Pro Phe Leu Leu Ile Leu Gly Ser Tyr Val Arg Ile Leu Ser 
     210                215                220
Thr Ile Phe Arg Met Pro Ser Ala Glu Gly Lys His Gln Ala Phe Ser 
 225                230                235                240
Thr Cys Ser Ala His Leu Leu Val Val Ser Leu Phe Tyr Ser Thr Ala 
                 245                250                255
Ile Leu Thr Tyr Phe Arg Pro Gln Ser Ser Ala Ser Ser Glu Ser Lys 
             260                265                270
Lys Leu Leu Ser Leu Ser Ser Thr Val Val Thr Pro Met Leu Asn Pro 
         275                280                285
Ile Ile Tyr Ser Ser Arg Asn Lys Glu Val Lys Ala Ala Leu Lys Arg 
     290                295                300
Leu Ile His Arg Thr Leu Gly Ser Gln Lys Leu 
 305                310                315



<210> 1224
<211> 663
<212> DNA
<213> Rattus norvegicus
<308> AF091569
<400> 1224

cttaacctg  cctttgccg  cctctgctt  tcctctgtc  caatgccca  gttgttgca  60
aacatgcag  gccaagttc  atccatccc  tatgcaggg  gcctggcac  gatatactt  120
tttctgttt  ttggagacc  tggaaactt  ctgcttgtg  ccatggcct  tgaccgcta  180
gtggccatc  gcttccccc  tcattacat  agcatcatg  gccccaagc  ctgtgtgag  240
ctggtggtg  tgtcctggg  gctgaccac  ttccatgcc  tgctgcaca  cctgctcat  300
gccagattg  cattccgtg  ggacagtgt  atccctcac  atttctgtg  tatgtctac  360
ctgctgaaa  tggcttgtc  tgacaccca  gataatgaa  tagcaatat  tatcttagg  420
ggccctata  ttgtactac  tttccttct  atcattgtt  cttatgcaa  aattgtttc  480
tccatcttc  aggtccctt  ttctcaaag  atccataaa  ccttctcca  ctgtggctc  540
cacctgtct  tggtgtcac  gatctatgg  acagtcatt  gtctctact  atgtccttc  600
gctaataac  ccactgtga  ggagactgt  atgtctttg  tgtacacaa  ggtgacacc  660
atg  663



<210> 1225
<211> 221
<212> PRT
<213> Rattus norvegicus
<308> AAC64591
<400> 1225

Leu Asn Leu Ser Phe Ala Asp Leu Cys Phe Ser Ser Val Thr Met Pro 
  1               5                  10                  15
Lys Leu Leu Gln Asn Met Gln Ser Gln Val Pro Ser Ile Pro Tyr Ala 
             20                  25                  30
Gly Cys Leu Ala Gln Ile Tyr Phe Phe Leu Phe Phe Gly Asp Leu Gly 
         35                  40                  45
Asn Phe Leu Leu Val Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 
     50                  55                  60
Phe Pro Leu His Tyr Met Ser Ile Met Ser Pro Lys Leu Cys Val Ser 
 65                  70                  75                  80
Leu Val Val Leu Ser Trp Val Leu Thr Thr Phe His Ala Met Leu His 
                 85                  90                  95
Thr Leu Leu Met Ala Arg Leu Ser Phe Arg Glu Asp Ser Val Ile Pro 
             100                105                110
His Tyr Phe Cys Asp Met Ser Thr Leu Leu Lys Val Ala Cys Pro Asp 
         115                120                125
Thr His Asp Asn Glu Leu Ala Ile Phe Ile Leu Gly Gly Pro Ile Val 
     130                135                140
Val Leu Pro Phe Leu Leu Ile Ile Val Ser Tyr Ala Arg Ile Val Ser 
 145                150                155                160
Ser Ile Phe Lys Val Pro Ser Ser Gln Ser Ile His Lys Ala Phe Ser 
                 165                170                175
Thr Cys Gly Ser His Leu Ser Val Val Ser Leu Ile Tyr Gly Thr Val 
             180                185                190
Ile Gly Leu Tyr Leu Cys Pro Ser Ala Asn Asn Ser Thr Val Lys Glu 
         195                200                205
Thr Val Met Ser Leu Met Tyr Thr Met Val Thr Pro Met 
     210                215                220



<210> 1226
<211> 945
<212> DNA
<213> Homo sapiens
<308> AF087916
<400> 1226

atgatggga  aaaatcaaa  cagcatctc  gacttcctg  tcctgggcc  gcccatcca  60
ccagagcag  aaaacctgt  ctatgccct  ttcttggcc  tgtatctta  caccctcct  120
gggaacctc  tcatcattg  cctcattcg  ctggactcc  atctccaca  gcctatgta  180
ttgtttctc  gcaacttgt  cttctctga  ctctgcttc  cttccgtga  cattcccaa  240
ttgttacag  acatgcaga  ccaggaccc  tccatcccc  atgcggact  cctgaccca  300
atgtacttc  tcctgttat  tggagacct  gagagcttc  tccttgtgg  catggccta  360
gaccgctat  tggccatct  cttccccct  cactacacc  ccatcatga  ccccatgct  420
tgtctcgcc  tggtggcgc  gtcctgggt  ctgaccacc  tccatgcca  gttacacac  480
ttactcatg  ccaggttgt  tttttgtgc  gacaatgtg  tcccccact  tttctgtga  540
atgtctgct  tgctgaagc  ggccttctc  gacactcga  ttaatgaat  ggtgatatt  600
atcatggga  ggctcattc  tgtcatccc  ttcctactc  tccttgggt  ctatgcaag  660
attgtctcc  ccatcctca  ggtcccttc  tctaagggt  tctgcaagg  cttctctac  720
tgtggctcc  acctgtctg  ggtgtcact  ttctatgga  ccgttattg  tctctactt  780
tgctcatca  ctaatagtt  tactctaaa  gacactgtc  tggctatga  gtacactgt  840
gtgaccccc  tgctgaacc  cttcatcta  agcctgagg  acagagaca  gaagggagc  900
ctgagcaga  tcattcatc  gaagaaaac  ttcttctct  tctga  945



<210> 1227
<211> 314
<212> PRT
<213> Homo sapiens
<308> AAF37309
<400> 1227

Met Met Gly Gln Asn Gln Thr Ser Ile Ser Asp Phe Leu Leu Leu Gly 
  1               5                  10                  15
Leu Pro Ile Gln Pro Glu Gln Gln Asn Leu Cys Tyr Ala Leu Phe Leu 
             20                  25                  30
Ala Met Tyr Leu Thr Thr Leu Leu Gly Asn Leu Leu Ile Ile Val Leu 
         35                  40                  45
Ile Arg Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ser 
     50                  55                  60
Asn Leu Ser Phe Ser Asp Leu Cys Phe Ser Ser Val Thr Ile Pro Lys 
 65                  70                  75                  80
Leu Leu Gln Asn Met Gln Asn Gln Asp Pro Ser Ile Pro Tyr Ala Asp 
                 85                  90                  95
Cys Leu Thr Gln Met Tyr Phe Phe Leu Leu Phe Gly Asp Leu Glu Ser 
             100                105                110
Phe Leu Leu Val Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe 
         115                120                125
Pro Leu His Tyr Thr Ala Ile Met Ser Pro Met Leu Cys Leu Ala Leu 
     130                135                140
Val Ala Leu Ser Trp Val Leu Thr Thr Phe His Ala Met Leu His Thr 
 145                150                155                160
Leu Leu Met Ala Arg Leu Cys Phe Cys Ala Asp Asn Val Ile Pro His 
                 165                170                175
Phe Phe Cys Asp Met Ser Ala Leu Leu Lys Leu Ala Phe Ser Asp Thr 
             180                185                190
Arg Val Asn Glu Trp Val Ile Phe Ile Met Gly Gly Leu Ile Leu Val 
         195                200                205
Ile Pro Phe Leu Leu Ile Leu Gly Ser Tyr Ala Arg Ile Val Ser Ser 
     210                215                220
Ile Leu Lys Val Pro Ser Ser Lys Gly Ile Cys Lys Ala Phe Ser Thr 
 225                230                235                240
Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Val Ile 
                 245                250                255
Gly Leu Tyr Leu Cys Ser Ser Ala Asn Ser Ser Thr Leu Lys Asp Thr 
             260                265                270
Val Met Ala Met Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 
         275                280                285
Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Gly Ala Leu Ser Arg Val 
     290                295                300
Ile His Gln Lys Lys Thr Phe Phe Ser Leu 
 305                310



<210> 1228
<211> 663
<212> DNA
<213> Rattus norvegicus
<308> AF091570
<400> 1228

ggcaatatg  ccttctctg  cctctgctt  tcctctgtt  cgatgccca  gttgttgca  60
aacatgcag  gccaagttc  atccatccc  tatgtaggc  gcctgtcac  aatatactt  120
tttctgttt  ttggagacc  cgggaactt  ctgcttgtg  ccatggcct  tgaccgcta  180
gtggccacc  gcttccccc  tcattacat  agcatcatg  gccccaagc  ctgtgtgag  240
ctggtggtg  tgtcctggg  gcggactac  ttccatgcc  tgctgcaca  cctgctcca  300
ggccagatt  tcattctgt  aggacaatg  gatccccac  ttttctgtg  catgtctgc  360
ctgctaaag  tggcctgct  tgacacccg  gttaatgag  ttgtgatat  tattgtggt  420
agcctcttt  ttgtccttc  atttgccct  attatcatg  cctatgtaa  aattgtgtc  480
tccattctc  aggtccctt  ttctcaagg  atttacaaa  ccttttcca  atgtggatc  540
cacctgtct  tagtgtcac  gttctatgg  acagtcatt  gtctctatt  atgtccttc  600
agtaataat  ctactgtga  ggagactgt  atgtctttg  tgtacacag  ggtgactcc  660
atg  663



<210> 1229
<211> 314
<212> PRT
<213> Rattus norvegicus
<308> CAA68842
<400> 1229

Met Thr Glu Arg Asn Gln Thr Val Ile Ser Gln Phe Leu Leu Leu Gly 
  1               5                  10                  15
Leu Pro Ile Pro Pro Glu His Gln His Val Phe Tyr Ala Leu Phe Leu 
             20                  25                  30
Ser Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Ile Ile Ile Ile Leu 
         35                  40                  45
Ile Leu Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ser 
     50                  55                  60
Asn Leu Ser Phe Ser Asp Leu Cys Phe Ser Ser Val Thr Met Pro Lys 
 65                  70                  75                  80
Leu Leu Gln Asn Met Gln Ser Gln Val Pro Ser Ile Pro Tyr Ala Gly 
                 85                  90                  95
Cys Leu Ser Gln Ile Tyr Phe Phe Leu Phe Phe Gly Asp Leu Gly Asn 
             100                105                110
Phe Leu Leu Val Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe 
         115                120                125
Pro Leu His Tyr Met Ser Ile Met Ser Pro Lys Leu Cys Val Ser Leu 
     130                135                140
Val Val Leu Ser Trp Val Leu Thr Thr Phe His Ala Met Leu His Thr 
 145                150                155                160
Leu Leu Met Ala Arg Leu Ser Phe Cys Glu Asp Asn Val Ile Pro His 
                 165                170                175
Phe Phe Cys Asp Met Ser Ala Leu Leu Lys Leu Ala Cys Ser Asp Thr 
             180                185                190
Arg Val Asn Glu Val Val Ile Phe Ile Val Val Ser Leu Phe Leu Val 
         195                200                205
Leu Pro Phe Ala Leu Ile Ile Met Ser Tyr Val Arg Ile Val Ser Ser 
     210                215                220
Ile Leu Lys Val Pro Ser Ser Gln Gly Ile Tyr Lys Ala Phe Ser Thr 
 225                230                235                240
Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Val Ile 
                 245                250                255
Gly Leu Tyr Leu Cys Pro Ser Ser Asn Asn Ser Thr Val Lys Glu Thr 
             260                265                270
Val Met Ser Leu Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 
         275                280                285
Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Gly Ala Met Glu Arg Ile 
     290                295                300
Phe Cys Lys Arg Lys Ile Gln Leu Asn Leu 
 305                310



<210> 1230
<211> 945
<212> DNA
<213> Homo sapiens
<308> AF087916
<400> 1230

atgatggga  aaaatcaaa  cagcatctc  gacttcctg  tcctgggcc  gcccatcca  60
ccagagcag  aaaacctgt  ctatgccct  ttcttggcc  tgtatctta  caccctcct  120
gggaacctc  tcatcattg  cctcattcg  ctggactcc  atctccaca  gcctatgta  180
ttgtttctc  gcaacttgt  cttctctga  ctctgcttc  cttccgtga  cattcccaa  240
ttgttacag  acatgcaga  ccaggaccc  tccatcccc  atgcggact  cctgaccca  300
atgtacttc  tcctgttat  tggagacct  gagagcttc  tccttgtgg  catggccta  360
gaccgctat  tggccatct  cttccccct  cactacacc  ccatcatga  ccccatgct  420
tgtctcgcc  tggtggcgc  gtcctgggt  ctgaccacc  tccatgcca  gttacacac  480
ttactcatg  ccaggttgt  tttttgtgc  gacaatgtg  tcccccact  tttctgtga  540
atgtctgct  tgctgaagc  ggccttctc  gacactcga  ttaatgaat  ggtgatatt  600
atcatggga  ggctcattc  tgtcatccc  ttcctactc  tccttgggt  ctatgcaag  660
attgtctcc  ccatcctca  ggtcccttc  tctaagggt  tctgcaagg  cttctctac  720
tgtggctcc  acctgtctg  ggtgtcact  ttctatgga  ccgttattg  tctctactt  780
tgctcatca  ctaatagtt  tactctaaa  gacactgtc  tggctatga  gtacactgt  840
gtgaccccc  tgctgaacc  cttcatcta  agcctgagg  acagagaca  gaagggagc  900
ctgagcaga  tcattcatc  gaagaaaac  ttcttctct  tctga  945



<210> 1231
<211> 314
<212> PRT
<213> Homo sapiens
<308> P30953
<400> 1231

Met Met Gly Gln Asn Gln Thr Ser Ile Ser Asp Phe Leu Leu Leu Gly 
  1               5                  10                  15
Leu Pro Ile Gln Pro Glu Gln Gln Asn Leu Cys Tyr Ala Leu Phe Leu 
             20                  25                  30
Ala Met Tyr Leu Thr Thr Leu Leu Gly Asn Leu Leu Ile Ile Val Leu 
         35                  40                  45
Ile Arg Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ser 
     50                  55                  60
Asn Leu Ser Phe Ser Asp Leu Cys Phe Ser Ser Val Thr Ile Pro Lys 
 65                  70                  75                  80
Leu Leu Gln Asn Met Gln Asn Gln Asp Pro Ser Ile Pro Tyr Ala Asp 
                 85                  90                  95
Cys Leu Thr Gln Met Tyr Phe Phe Leu Leu Phe Gly Asp Leu Glu Ser 
             100                105                110
Phe Leu Leu Val Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe 
         115                120                125
Pro Leu His Tyr Thr Ala Ile Met Ser Pro Met Leu Cys Leu Ala Leu 
     130                135                140
Val Ala Leu Ser Trp Val Leu Thr Thr Phe His Ala Met Leu His Thr 
 145                150                155                160
Leu Leu Met Ala Arg Leu Cys Phe Cys Ala Asp Asn Val Ile Pro His 
                 165                170                175
Phe Phe Cys Asp Met Ser Ala Leu Leu Lys Leu Ala Phe Ser Asp Thr 
             180                185                190
Arg Val Asn Glu Trp Val Ile Phe Ile Met Gly Gly Leu Ile Leu Val 
         195                200                205
Ile Pro Phe Leu Leu Ile Leu Gly Ser Tyr Ala Arg Ile Val Ser Ser 
     210                215                220
Ile Leu Lys Val Pro Ser Ser Lys Gly Ile Cys Lys Ala Phe Ser Thr 
 225                230                235                240
Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Val Ile 
                 245                250                255
Gly Leu Tyr Leu Cys Ser Ser Ala Asn Ser Ser Thr Leu Lys Asp Thr 
             260                265                270
Val Met Ala Met Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 
         275                280                285
Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Gly Ala Leu Ser Arg Val 
     290                295                300
Ile His Gln Lys Lys Thr Phe Phe Ser Leu 
 305                310



<210> 1232
<211> 663
<212> DNA
<213> Rattus norvegicus
<308> AF091578
<400> 1232

ggtaatctg  ccttcgttg  cctctgtta  tcttctgtt  ttgtcccca  agccatggc  60
aacttactt  cttccacta  ggccatcag  tttgcagga  gtgccactc  gttcttcct  120
ttctccctt  tggttacta  tgaaagctt  ctattggca  tcatggcct  cgatcgctt  180
atggccatc  gcagtcccc  gaggtaccc  gtgaccatg  gccctatgg  atgtgcccg  240
ctggtcctg  gtgcctact  tggtggctg  ctgcactcc  tcatagaga  cagcctcac  300
ttccggctg  ccttctgca  ctccaaccg  atcaaccac  tctactgtg  tgtgccccc  360
ttgctccag  tggcctgtg  tgacacaac  ctcaatgag  ttgtcatgt  tggcatctg  420
ggactcatc  tcgtgtcta  cactctcgt  gtcctggtc  cctatggct  catcacagt  480
accattctc  ggatgcgct  tgggtcagg  cggcacaag  tcttctcta  ttgtggctc  540
cacatgaca  ctgtgtcct  gttttatgg  actgtgttt  tcatgtatg  tcagccagg  600
gctctaaca  ccatggagc  ggggaaagt  gcctctgtc  tctacgccc  ggttatccc  660
atg  663



<210> 1233
<211> 221
<212> PRT
<213> Rattus norvegicus
<308> AAC64598
<400> 1233

Gly Asn Leu Ser Phe Val Asp Leu Cys Tyr Ser Ser Val Ile Val Pro 
  1               5                  10                  15
Lys Ala Met Ala Asn Leu Leu Ser Ser Thr Lys Ala Ile Ser Phe Ala 
             20                  25                  30
Gly Cys Ala Thr Gln Phe Phe Leu Phe Ser Leu Leu Val Thr Thr Glu 
         35                  40                  45
Ser Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Met Ala Ile Cys 
     50                  55                  60
Ser Pro Leu Arg Tyr Pro Val Thr Met Cys Pro Met Ala Cys Ala Arg 
 65                  70                  75                  80
Leu Val Leu Gly Ala Tyr Cys Gly Gly Cys Leu His Ser Ile Ile Glu 
                 85                  90                  95
Ser Ser Leu Thr Phe Arg Leu Pro Phe Cys Ser Ser Asn Arg Ile Asn 
             100                105                110
His Phe Tyr Cys Asp Val Pro Pro Leu Leu Gln Leu Ala Cys Ala Asp 
         115                120                125
Thr Thr Leu Asn Glu Leu Val Met Phe Gly Ile Cys Gly Leu Ile Ile 
     130                135                140
Val Ser Thr Thr Leu Val Val Leu Val Ser Tyr Gly Tyr Ile Thr Val 
 145                150                155                160
Thr Ile Leu Arg Met Arg Ser Gly Ser Gly Arg His Lys Leu Phe Ser 
                 165                170                175
Thr Cys Gly Ser His Met Thr Ala Val Ser Leu Phe Tyr Gly Thr Val 
             180                185                190
Phe Val Met Tyr Ala Gln Pro Gly Ala Leu Thr Ser Met Glu Gln Gly 
         195                200                205
Lys Val Ala Ser Val Phe Tyr Ala Leu Val Ile Pro Met 
     210                215                220



<210> 1234
<211> 945
<212> DNA
<213> Homo sapiens
<308> NM_006637
<400> 1234

atggaattt  cagatagaa  ctacacgtt  gtcactgag  ttattctat  aggttttcc  60
actcgccct  aactgcaga  tgtcctgtt  ctcatgttt  tgacattgt  tgctataat  120
ctgataggg  acattggat  gatgctgtt  atcaggatt  atcctcacc  tcaaacccc  180
atgtatttt  tccttagca  cctatcatt  gtagacctt  gctatttct  agacattgt  240
cccaaaatg  tggtcaatt  cctctcgga  aacaaatct  tttcctatt  tgggtgtgc  300
ctgcagttt  attttttct  tacttttgc  gatacagaa  ccttcatcc  ggccgccat  360
gcctatgat  gctatgtcg  catctgtaa  cctttattg  acacagttg  gatgtctag  420
ggcatctgt  tgcggttga  tgtcttgtc  taccttgga  gcaacatga  ttccctggt  480
cacacatcc  ttgccttta  tctgaaata  tgtgacaaa  atgttatta  tcatttttt  540
tgtgacctc  ctcccctgc  taaactatc  tgcactgac  caacaatta  tgagtggct  600
ctctccaca  acggcagct  agtggaaat  atttgtttt  tcatcatca  catctccta  660
tttttcatt  ttctctcag  cttaaagat  cgctctttc  gtgggagga  gaagacctt  720
tctacatgc  cctctcacc  gacttcagt  acgatctac  aagggactc  cctctttat  780
tactcacgg  ccagctacc  gtattctcc  aacactgat  aaattatct  agtgttcta  840
accattttc  ttccagtgc  gaatccgtt  atttatagt  tgagaaata  agatgtaaa  900
gatgcagct  agaaagttc  aagatcaaa  gtagattct  catga  945



<210> 1235
<211> 314
<212> PRT
<213> Homo sapiens
<308> NP_006628
<400> 1235

Met Glu Phe Thr Asp Arg Asn Tyr Thr Leu Val Thr Glu Phe Ile Leu 
  1               5                  10                  15
Leu Gly Phe Pro Thr Arg Pro Glu Leu Gln Ile Val Leu Phe Leu Met 
             20                  25                  30
Phe Leu Thr Leu Tyr Ala Ile Ile Leu Ile Gly Asn Ile Gly Leu Met 
         35                  40                  45
Leu Leu Ile Arg Ile Asp Pro His Leu Gln Thr Pro Met Tyr Phe Phe 
     50                  55                  60
Leu Ser Asn Leu Ser Phe Val Asp Leu Cys Tyr Phe Ser Asp Ile Val 
 65                  70                  75                  80
Pro Lys Met Leu Val Asn Phe Leu Ser Glu Asn Lys Ser Ile Ser Tyr 
                 85                  90                  95
Tyr Gly Cys Ala Leu Gln Phe Tyr Phe Phe Cys Thr Phe Ala Asp Thr 
             100                105                110
Glu Ser Phe Ile Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 
         115                120                125
Cys Asn Pro Leu Leu Tyr Thr Val Val Met Ser Arg Gly Ile Cys Met 
     130                135                140
Arg Leu Ile Val Leu Ser Tyr Leu Gly Gly Asn Met Ser Ser Leu Val 
 145                150                155                160
His Thr Ser Phe Ala Phe Ile Leu Lys Tyr Cys Asp Lys Asn Val Ile 
                 165                170                175
Asn His Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ser Cys Thr 
             180                185                190
Asp Thr Thr Ile Asn Glu Trp Leu Leu Ser Thr Tyr Gly Ser Ser Val 
         195                200                205
Glu Ile Ile Cys Phe Ile Ile Ile Ile Ile Ser Tyr Phe Phe Ile Leu 
     210                215                220
Leu Ser Val Leu Lys Ile Arg Ser Phe Ser Gly Arg Lys Lys Thr Phe 
 225                230                235                240
Ser Thr Cys Ala Ser His Leu Thr Ser Val Thr Ile Tyr Gln Gly Thr 
                 245                250                255
Leu Leu Phe Ile Tyr Ser Arg Pro Ser Tyr Leu Tyr Ser Pro Asn Thr 
             260                265                270
Asp Lys Ile Ile Ser Val Phe Tyr Thr Ile Phe Ile Pro Val Leu Asn 
         275                280                285
Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Ala Glu 
     290                295                300
Lys Val Leu Arg Ser Lys Val Asp Ser Ser 
 305                310



<210> 1236
<211> 534
<212> DNA
<213> Rattus norvegicus
<308> AF091834
<400> 1236

gagcagaga  ggctcggtg  caacagcgg  ctgcacatc  tcatctttg  tgaaatcga  60
gccatctgc  agcagagag  gagcatggc  ggcagcacc  gggtgcacg  cactgtggt  120
aaccagctg  tgtccaaga  cgatggcgt  gagcagctg  acaacatcc  cgttattgg  180
atgaccaat  gaccagatt  gattgatga  gctctcctt  gacctggaa  actggaagt  240
aagatggag  taggcttac  agatgagaa  ggccgactg  agatccttc  catccacac  300
gcaaggatg  gagggcacc  gctactgtc  gcggatgtg  acatcaagg  actggctgt  360
gagactaag  atttcagtg  cgccgagct  gagggcctg  tgcgagcag  gcagtccac  420
gccatgaac  gacacataa  ggccagcac  aaagtggaa  tagacatgg  gaaggcaga  480
agcctgcag  tgacaagag  ggacttcct  gcttccctg  agaatgata  caag  534



<210> 1237
<211> 178
<212> PRT
<213> Rattus norvegicus
<308> AAC61595
<400> 1237

Glu Gln Arg Arg Leu Gly Ala Asn Ser Gly Leu His Ile Ile Ile Phe 
  1               5                  10                  15
Asp Glu Ile Asp Ala Ile Cys Lys Gln Arg Gly Ser Met Ala Gly Ser 
             20                  25                  30
Thr Gly Val His Asp Thr Val Val Asn Gln Leu Leu Ser Lys Ile Asp 
         35                  40                  45
Gly Val Glu Gln Leu Asn Asn Ile Leu Val Ile Gly Met Thr Asn Arg 
     50                  55                  60
Pro Asp Leu Ile Asp Glu Ala Leu Leu Arg Pro Gly Arg Leu Glu Val 
 65                  70                  75                  80
Lys Met Glu Ile Gly Leu Pro Asp Glu Lys Gly Arg Leu Gln Ile Leu 
                 85                  90                  95
His Ile His Thr Ala Arg Met Arg Gly His Gln Leu Leu Ser Ala Asp 
             100                105                110
Val Asp Ile Lys Glu Leu Ala Val Glu Thr Lys Asn Phe Ser Gly Ala 
         115                120                125
Glu Leu Glu Gly Leu Val Arg Ala Ala Gln Ser Thr Ala Met Asn Arg 
     130                135                140
His Ile Lys Ala Ser Thr Lys Val Glu Val Asp Met Glu Lys Ala Glu 
 145                150                155                160
Ser Leu Gln Val Thr Arg Gly Asp Phe Leu Ala Ser Leu Glu Asn Asp 
                 165                170                175
Ile Lys 
             180



<210> 1239
<211> 744
<212> PRT
<213> Homo sapiens
<308> P46459
<400> 1239

Met Ala Gly Arg Ser Met Gln Ala Ala Arg Cys Pro Thr Asp Glu Leu 
  1               5                  10                  15
Ser Leu Thr Asn Cys Ser Val Val Asn Glu Lys Asp Phe Gln Ser Gly 
             20                  25                  30
Gln His Val Ile Val Arg Thr Ser Pro Asn His Arg Tyr Thr Phe Thr 
         35                  40                  45
Leu Lys Thr His Pro Ser Val Val Pro Gly Ser Ile Ala Phe Ser Leu 
     50                  55                  60
Pro Gln Arg Lys Trp Ala Gly Leu Ser Ile Gly Gln Glu Ile Glu Val 
 65                  70                  75                  80
Ser Leu Tyr Thr Phe Asp Lys Ala Lys Gln Cys Ile Gly Thr Met Thr 
                 85                  90                  95
Ile Glu Ile Asp Phe Leu Gln Lys Lys Ser Asn Asp Ser Asn Pro Tyr 
             100                105                110
Asp Thr Asp Lys Met Ala Ala Glu Phe Ile Gln Gln Phe Asn Asn Gln 
         115                120                125
Ala Tyr Ser Val Gly Gln Gln Leu Val Phe Ser Phe Asn Glu Lys Leu 
     130                135                140
Phe Gly Leu Leu Val Lys Asp Ile Glu Ser Met Asp Pro Ser Ile Leu 
 145                150                155                160
Lys Gly Glu Pro Ala Thr Gly Lys Arg Gln Lys Ile Glu Val Gly Leu 
                 165                170                175
Val Val Gly Asn Ser Gln Val Ala Phe Glu Lys Ala Glu Asn Ser Ser 
             180                185                190
Leu Asn Leu Ile Gly Lys Ala Lys Thr Lys Glu Asn Arg Gln Ser Ile 
         195                200                205
Ile Asn Pro Asp Trp Asn Phe Glu Lys Met Gly Ile Gly Gly Leu Asp 
     210                215                220
Lys Glu Phe Ser Asp Ile Phe Arg Arg Ala Phe Ala Phe Arg Val Phe 
 225                230                235                240
Pro Pro Glu Ile Val Glu Gln Met Gly Cys Ile His Val Lys Gly Ile 
                 245                250                255
Leu Leu Tyr Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala Arg Gln 
             260                265                270
Ile Gly Lys Met Leu Asn Ala Arg Glu Pro Lys Val Val Asn Gly Pro 
         275                280                285
Glu Ile Leu Asn Lys Tyr Val Gly Glu Ser Glu Ala Asn Ile Arg Lys 
     290                295                300
Leu Phe Ala Asp Ala Glu Glu Glu Gln Arg Arg Leu Gly Ala Asn Ser 
 305                310                315                320
Gly Leu His Ile Ile Ile Phe Asp Glu Ile Asp Ala Ile Cys Lys Gln 
                 325                330                335
Arg Gly Ser Met Ala Gly Ser Thr Gly Val His Asp Thr Val Val Asn 
             340                345                350
Gln Leu Leu Ser Lys Ile Asp Gly Val Glu Gln Leu Asn Asn Ile Leu 
         355                360                365
Val Ile Gly Met Thr Asn Arg Pro Asp Leu Ile Asp Glu Ala Leu Leu 
     370                375                380
Arg Pro Gly Arg Leu Glu Val Lys Met Glu Ile Gly Leu Pro Asp Glu 
 385                390                395                400
Lys Gly Arg Leu Gln Ile Leu His Ile His Thr Ala Arg Met Arg Gly 
                 405                410                415
His Gln Leu Leu Ser Ala Asp Val Asp Ile Lys Glu Leu Ala Val Glu 
             420                425                430
Thr Lys Asn Phe Ser Gly Ala Glu Leu Glu Gly Leu Val Arg Ala Ala 
         435                440                445
Gln Ser Thr Ala Met Asn Arg His Ile Lys Ala Ser Thr Lys Val Glu 
     450                455                460
Val Asp Met Glu Lys Ala Glu Ser Leu Gln Val Thr Arg Gly Asp Phe 
 465                470                475                480
Leu Ala Ser Leu Glu Asn Asp Ile Lys Pro Ala Phe Gly Thr Asn Gln 
                 485                490                495
Glu Asp Tyr Ala Ser Tyr Ile Met Asn Gly Ile Ile Lys Trp Gly Asp 
             500                505                510
Pro Val Thr Arg Val Leu Asp Asp Gly Glu Leu Leu Val Gln Gln Thr 
         515                520                525
Lys Asn Ser Asp Arg Thr Pro Leu Val Ser Val Leu Leu Glu Gly Pro 
     530                535                540
Pro His Ser Gly Lys Thr Ala Leu Ala Ala Lys Ile Ala Glu Glu Ser 
 545                550                555                560
Asn Phe Pro Phe Ile Lys Ile Cys Ser Pro Asp Lys Met Ile Gly Phe 
                 565                570                575
Ser Glu Thr Ala Lys Cys Gln Ala Met Lys Lys Ile Phe Asp Asp Ala 
             580                585                590
Tyr Lys Ser Gln Leu Ser Cys Val Val Val Asp Asp Ile Glu Arg Leu 
         595                600                605
Leu Asp Tyr Val Pro Ile Gly Pro Arg Phe Ser Asn Leu Val Leu Gln 
     610                615                620
Ala Leu Leu Val Leu Leu Lys Lys Ala Pro Pro Gln Gly Arg Lys Leu 
 625                630                635                640
Leu Ile Ile Gly Thr Thr Ser Arg Lys Asp Val Leu Gln Glu Met Glu 
                 645                650                655
Met Leu Asn Ala Phe Ser Thr Thr Ile His Val Pro Asn Ile Ala Thr 
             660                665                670
Gly Glu Gln Leu Leu Glu Ala Leu Glu Leu Leu Gly Asn Leu Lys Asp 
         675                680                685
Lys Glu Arg Thr Thr Ile Ala Gln Gln Val Lys Gly Lys Lys Val Trp 
     690                695                700
Ile Gly Ile Lys Lys Leu Leu Met Leu Ile Glu Met Ser Leu Gln Met 
 705                710                715                720
Asp Pro Glu Tyr Arg Val Arg Lys Phe Leu Ala Leu Leu Arg Glu Glu 
                 725                730                735
Gly Ala Ser Pro Leu Asp Phe Asp 
             740



<210> 1240
<211> 534
<212> DNA
<213> Rattus norvegicus
<308> AF091834
<400> 1240

gagcagaga  ggctcggtg  caacagcgg  ctgcacatc  tcatctttg  tgaaatcga  60
gccatctgc  agcagagag  gagcatggc  ggcagcacc  gggtgcacg  cactgtggt  120
aaccagctg  tgtccaaga  cgatggcgt  gagcagctg  acaacatcc  cgttattgg  180
atgaccaat  gaccagatt  gattgatga  gctctcctt  gacctggaa  actggaagt  240
aagatggag  taggcttac  agatgagaa  ggccgactg  agatccttc  catccacac  300
gcaaggatg  gagggcacc  gctactgtc  gcggatgtg  acatcaagg  actggctgt  360
gagactaag  atttcagtg  cgccgagct  gagggcctg  tgcgagcag  gcagtccac  420
gccatgaac  gacacataa  ggccagcac  aaagtggaa  tagacatgg  gaaggcaga  480
agcctgcag  tgacaagag  ggacttcct  gcttccctg  agaatgata  caag  534



<210> 1241
<211> 178
<212> PRT
<213> Rattus norvegicus
<308> AAC61595
<400> 1241

Glu Gln Arg Arg Leu Gly Ala Asn Ser Gly Leu His Ile Ile Ile Phe 
  1               5                  10                  15
Asp Glu Ile Asp Ala Ile Cys Lys Gln Arg Gly Ser Met Ala Gly Ser 
             20                  25                  30
Thr Gly Val His Asp Thr Val Val Asn Gln Leu Leu Ser Lys Ile Asp 
         35                  40                  45
Gly Val Glu Gln Leu Asn Asn Ile Leu Val Ile Gly Met Thr Asn Arg 
     50                  55                  60
Pro Asp Leu Ile Asp Glu Ala Leu Leu Arg Pro Gly Arg Leu Glu Val 
 65                  70                  75                  80
Lys Met Glu Ile Gly Leu Pro Asp Glu Lys Gly Arg Leu Gln Ile Leu 
                 85                  90                  95
His Ile His Thr Ala Arg Met Arg Gly His Gln Leu Leu Ser Ala Asp 
             100                105                110
Val Asp Ile Lys Glu Leu Ala Val Glu Thr Lys Asn Phe Ser Gly Ala 
         115                120                125
Glu Leu Glu Gly Leu Val Arg Ala Ala Gln Ser Thr Ala Met Asn Arg 
     130                135                140
His Ile Lys Ala Ser Thr Lys Val Glu Val Asp Met Glu Lys Ala Glu 
 145                150                155                160
Ser Leu Gln Val Thr Arg Gly Asp Phe Leu Ala Ser Leu Glu Asn Asp 
                 165                170                175
Ile Lys 
             180



<210> 1243
<211> 744
<212> PRT
<213> Homo sapiens
<308> P46459
<400> 1243

Met Ala Gly Arg Ser Met Gln Ala Ala Arg Cys Pro Thr Asp Glu Leu 
  1               5                  10                  15
Ser Leu Thr Asn Cys Ser Val Val Asn Glu Lys Asp Phe Gln Ser Gly 
             20                  25                  30
Gln His Val Ile Val Arg Thr Ser Pro Asn His Arg Tyr Thr Phe Thr 
         35                  40                  45
Leu Lys Thr His Pro Ser Val Val Pro Gly Ser Ile Ala Phe Ser Leu 
     50                  55                  60
Pro Gln Arg Lys Trp Ala Gly Leu Ser Ile Gly Gln Glu Ile Glu Val 
 65                  70                  75                  80
Ser Leu Tyr Thr Phe Asp Lys Ala Lys Gln Cys Ile Gly Thr Met Thr 
                 85                  90                  95
Ile Glu Ile Asp Phe Leu Gln Lys Lys Ser Asn Asp Ser Asn Pro Tyr 
             100                105                110
Asp Thr Asp Lys Met Ala Ala Glu Phe Ile Gln Gln Phe Asn Asn Gln 
         115                120                125
Ala Tyr Ser Val Gly Gln Gln Leu Val Phe Ser Phe Asn Glu Lys Leu 
     130                135                140
Phe Gly Leu Leu Val Lys Asp Ile Glu Ser Met Asp Pro Ser Ile Leu 
 145                150                155                160
Lys Gly Glu Pro Ala Thr Gly Lys Arg Gln Lys Ile Glu Val Gly Leu 
                 165                170                175
Val Val Gly Asn Ser Gln Val Ala Phe Glu Lys Ala Glu Asn Ser Ser 
             180                185                190
Leu Asn Leu Ile Gly Lys Ala Lys Thr Lys Glu Asn Arg Gln Ser Ile 
         195                200                205
Ile Asn Pro Asp Trp Asn Phe Glu Lys Met Gly Ile Gly Gly Leu Asp 
     210                215                220
Lys Glu Phe Ser Asp Ile Phe Arg Arg Ala Phe Ala Phe Arg Val Phe 
 225                230                235                240
Pro Pro Glu Ile Val Glu Gln Met Gly Cys Ile His Val Lys Gly Ile 
                 245                250                255
Leu Leu Tyr Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala Arg Gln 
             260                265                270
Ile Gly Lys Met Leu Asn Ala Arg Glu Pro Lys Val Val Asn Gly Pro 
         275                280                285
Glu Ile Leu Asn Lys Tyr Val Gly Glu Ser Glu Ala Asn Ile Arg Lys 
     290                295                300
Leu Phe Ala Asp Ala Glu Glu Glu Gln Arg Arg Leu Gly Ala Asn Ser 
 305                310                315                320
Gly Leu His Ile Ile Ile Phe Asp Glu Ile Asp Ala Ile Cys Lys Gln 
                 325                330                335
Arg Gly Ser Met Ala Gly Ser Thr Gly Val His Asp Thr Val Val Asn 
             340                345                350
Gln Leu Leu Ser Lys Ile Asp Gly Val Glu Gln Leu Asn Asn Ile Leu 
         355                360                365
Val Ile Gly Met Thr Asn Arg Pro Asp Leu Ile Asp Glu Ala Leu Leu 
     370                375                380
Arg Pro Gly Arg Leu Glu Val Lys Met Glu Ile Gly Leu Pro Asp Glu 
 385                390                395                400
Lys Gly Arg Leu Gln Ile Leu His Ile His Thr Ala Arg Met Arg Gly 
                 405                410                415
His Gln Leu Leu Ser Ala Asp Val Asp Ile Lys Glu Leu Ala Val Glu 
             420                425                430
Thr Lys Asn Phe Ser Gly Ala Glu Leu Glu Gly Leu Val Arg Ala Ala 
         435                440                445
Gln Ser Thr Ala Met Asn Arg His Ile Lys Ala Ser Thr Lys Val Glu 
     450                455                460
Val Asp Met Glu Lys Ala Glu Ser Leu Gln Val Thr Arg Gly Asp Phe 
 465                470                475                480
Leu Ala Ser Leu Glu Asn Asp Ile Lys Pro Ala Phe Gly Thr Asn Gln 
                 485                490                495
Glu Asp Tyr Ala Ser Tyr Ile Met Asn Gly Ile Ile Lys Trp Gly Asp 
             500                505                510
Pro Val Thr Arg Val Leu Asp Asp Gly Glu Leu Leu Val Gln Gln Thr 
         515                520                525
Lys Asn Ser Asp Arg Thr Pro Leu Val Ser Val Leu Leu Glu Gly Pro 
     530                535                540
Pro His Ser Gly Lys Thr Ala Leu Ala Ala Lys Ile Ala Glu Glu Ser 
 545                550                555                560
Asn Phe Pro Phe Ile Lys Ile Cys Ser Pro Asp Lys Met Ile Gly Phe 
                 565                570                575
Ser Glu Thr Ala Lys Cys Gln Ala Met Lys Lys Ile Phe Asp Asp Ala 
             580                585                590
Tyr Lys Ser Gln Leu Ser Cys Val Val Val Asp Asp Ile Glu Arg Leu 
         595                600                605
Leu Asp Tyr Val Pro Ile Gly Pro Arg Phe Ser Asn Leu Val Leu Gln 
     610                615                620
Ala Leu Leu Val Leu Leu Lys Lys Ala Pro Pro Gln Gly Arg Lys Leu 
 625                630                635                640
Leu Ile Ile Gly Thr Thr Ser Arg Lys Asp Val Leu Gln Glu Met Glu 
                 645                650                655
Met Leu Asn Ala Phe Ser Thr Thr Ile His Val Pro Asn Ile Ala Thr 
             660                665                670
Gly Glu Gln Leu Leu Glu Ala Leu Glu Leu Leu Gly Asn Leu Lys Asp 
         675                680                685
Lys Glu Arg Thr Thr Ile Ala Gln Gln Val Lys Gly Lys Lys Val Trp 
     690                695                700
Ile Gly Ile Lys Lys Leu Leu Met Leu Ile Glu Met Ser Leu Gln Met 
 705                710                715                720
Asp Pro Glu Tyr Arg Val Arg Lys Phe Leu Ala Leu Leu Arg Glu Glu 
                 725                730                735
Gly Ala Ser Pro Leu Asp Phe Asp 
             740



<210> 1244
<211> 2148
<212> DNA
<213> Rattus norvegicus
<308> AF092450
<400> 1244

atggcggag  gagagagcg  cctgagcgg  ggtgccgcg  ccccaccgg  cgcttcccc  60
ttcctggga  tgcacatcg  gtcgcctcc  aatttcagg  tcacccatg  tgtcagcct  120
gaggagttt  aggatgaag  cctttcgga  atcactgat  agtgtggca  cagcctgca  180
tgcaaagac  ccttgtctc  ccggatgga  ctgatcgac  cggcaagtg  cactccggg  240
gccgaggac  acgaagagg  cgacgacga  ctcgctgcc  aacggccag  agtggggcc  300
tccaaagcc  agtctggcc  ggagccggc  tctcgcagc  agggtcagg  ccagggccc  360
ggcacaggc  gcggagaca  ctaccggcc  aagaggcct  ccacgctca  ccttttccc  420
caggtgccg  ggtctcagg  cacgctgaa  aataactct  taggcaaaa  gcacagttg  480
caggaccgt  tgtctcgat  atcctcccc  ctgaagaca  gggagcaga  gcctccaca  540
gaacatatc  gcctgagtg  tgagctgcc  ccccagggc  gtcctgttc  cacccagga  600
cgtggcact  ccaccgaca  cccttgtcg  cgtactgca  ccacccaga  ggcacctcc  660
agtggtccc  ctgccactg  acctggtgg  cggggccac  cccatcgag  tcgaatcca  720
tatcaggca  atgtgcggc  cgaggcgac  gaggagatc  acctgaccc  agtgcagag  780
cccccagac  ctgcagaac  cacctccac  ttcttgcca  ccactgaga  ccggatgtc  840
gtcagctcg  atcctgacc  tgccgctta  tctgtaact  cagggcgac  gcacccttc  900
atcagtgaa  aggatgagg  cttcgactg  ctgtcatcc  cagagcaag  tgagccacc  960
ggtggaggg  ggcggggaa  cctcgggga  ccaccaccg  ctccacggg  ctcactgag  1020
tcggacacc  gcgcactgt  ctacgactc  gtcaagtac  cactggtgg  ggatgagca  1080
gcccagctt  agttggtga  cctgcggcc  tgttttgga  attacagtg  cgaaagcga  1140
tctgccact  tctatgaca  ctgtgcctc  gcctcctcg  cctacgagt  agccattgg  1200
gaggaatat  aggaggccc  tcaaccccg  cctcccacc  gcctgtcag  ggactccac  1260
ccggatgag  ctgacgtcc  cttctctaa  aagtttctg  atgtcttca  gagtggtcg  1320
tctcgttcc  ccagtgccg  gtcctttgg  ctgttctcc  gtgtcatca  tggggagga  1380
catgagcaa  cccatcggg  tatattcag  tttgtgcct  ggcatgaag  tgaacttga  1440
ctggaagtg  acgaccctc  gctggtgga  ctgcaggca  aagactatt  gtatgaggc  1500
tataacatg  gcactggag  ccgtggtgt  tttcctgcc  actatgcca  tgaggtcac  1560
aaggagcct  agcacatgg  agcccttgc  aaaaacagc  actggattg  ccagttccg  1620
gtgaagttc  tgggctctg  ccaggttcc  tatcacaag  gcaatgatg  cctctgtgc  1680
gctatgcaa  agatcgcca  cacccgccg  ctcaccgtg  actttaacc  gccctccag  1740
tgtgtcctt  aaatcagcg  taggggtgt  aagataggt  tcaaagctg  tgaagctca  1800
gaggccaag  gaaataaat  tagccactt  ttccagcta  aaaacatct  tttctgtgg  1860
taccatcca  agaacaaca  gtactttgg  tttatcact  agcaccctg  tgaccaccg  1920
tttgcctgc  atgtctttg  gtctgaaga  tccaccaaa  ccctggcag  gtctgtggg  1980
cgtgcattt  agcagttct  caagcaatt  gtggaatat  cctgtccta  agaagatat  2040
tacttggag  ccatggccc  ggtgcagct  caggtcgac  tcgagatca  acgggcggc  2100
gcagaacaa  aactcatct  agaagagga  ctgaatggg  ccgcatag  2148



<210> 1245
<211> 708
<212> PRT
<213> Rattus norvegicus
<308> Q9R237
<400> 1245

Met Ala Glu Arg Glu Ser Gly Leu Ser Gly Gly Ala Ala Ser Pro Pro 
  1               5                  10                  15
Ala Ala Ser Pro Phe Leu Gly Leu His Ile Ala Ser Pro Pro Asn Phe 
             20                  25                  30
Arg Leu Thr His Asp Ile Ser Leu Glu Glu Phe Glu Asp Glu Asp Leu 
         35                  40                  45
Ser Glu Ile Thr Asp Glu Cys Gly Ile Ser Leu Gln Cys Lys Asp Thr 
     50                  55                  60
Leu Ser Leu Arg Pro Pro Arg Ala Gly Leu Leu Ser Ala Gly Ser Ser 
 65                  70                  75                  80
Gly Ser Ala Gly Ser Arg Leu Gln Ala Glu Met Leu Gln Met Asp Leu 
                 85                  90                  95
Ile Asp Ala Ala Ser Asp Thr Pro Gly Ala Glu Asp Asp Glu Glu Asp 
             100                105                110
Asp Asp Glu Leu Ala Ala Gln Arg Pro Gly Val Gly Pro Ser Lys Ala 
         115                120                125
Glu Ser Gly Gln Glu Pro Ala Ser Arg Ser Gln Gly Gln Gly Gln Gly 
     130                135                140
Pro Gly Thr Gly Ser Gly Asp Thr Tyr Arg Pro Lys Arg Pro Thr Thr 
 145                150                155                160
Leu Asn Leu Phe Pro Gln Val Pro Arg Ser Gln Asp Thr Leu Asn Asn 
                 165                170                175
Asn Ser Leu Gly Lys Lys His Ser Trp Gln Asp Arg Val Ser Arg Ser 
             180                185                190
Ser Ser Pro Leu Lys Thr Gly Glu Gln Thr Pro Pro His Glu His Ile 
         195                200                205
Cys Leu Ser Asp Glu Leu Pro Pro Gln Gly Ser Pro Val Pro Thr Gln 
     210                215                220
Asp Arg Gly Thr Ser Thr Asp Ser Pro Cys Arg Arg Thr Ala Ala Thr 
 225                230                235                240
Gln Met Ala Pro Pro Ser Gly Pro Pro Ala Thr Ala Pro Gly Gly Arg 
                 245                250                255
Gly His Ser His Arg Asp Arg Ile His Tyr Gln Ala Asp Val Arg Leu 
             260                265                270
Glu Ala Thr Glu Glu Ile Tyr Leu Thr Pro Val Gln Arg Pro Pro Asp 
         275                280                285
Pro Ala Glu Pro Thr Ser Thr Phe Leu Pro Pro Thr Glu Ser Arg Met 
     290                295                300
Ser Val Ser Ser Asp Pro Asp Pro Ala Ala Tyr Ser Val Thr Ala Gly 
 305                310                315                320
Arg Pro His Pro Ser Ile Ser Glu Glu Asp Glu Gly Phe Asp Cys Leu 
                 325                330                335
Ser Ser Pro Glu Gln Ala Glu Pro Pro Gly Gly Gly Trp Arg Gly Ser 
             340                345                350
Leu Gly Glu Pro Pro Pro Pro Pro Arg Ala Ser Leu Ser Ser Asp Thr 
         355                360                365
Ser Ala Leu Ser Tyr Asp Ser Val Lys Tyr Thr Leu Val Val Asp Glu 
     370                375                380
His Ala Gln Leu Glu Leu Val Ser Leu Arg Pro Cys Phe Gly Asp Tyr 
 385                390                395                400
Ser Asp Glu Ser Asp Ser Ala Thr Val Tyr Asp Asn Cys Ala Ser Ala 
                 405                410                415
Ser Ser Pro Tyr Glu Ser Ala Ile Gly Glu Glu Tyr Glu Glu Ala Pro 
             420                425                430
Gln Pro Arg Pro Pro Thr Cys Leu Ser Glu Asp Ser Thr Pro Asp Glu 
         435                440                445
Pro Asp Val His Phe Ser Lys Lys Phe Leu Asn Val Phe Met Ser Gly 
     450                455                460
Arg Ser Arg Ser Ser Ser Ala Glu Ser Phe Gly Leu Phe Ser Cys Val 
 465                470                475                480
Ile Asn Gly Glu Glu His Glu Gln Thr His Arg Ala Ile Phe Arg Phe 
                 485                490                495
Val Pro Arg His Glu Asp Glu Leu Glu Leu Glu Val Asp Asp Pro Leu 
             500                505                510
Leu Val Glu Leu Gln Ala Glu Asp Tyr Trp Tyr Glu Ala Tyr Asn Met 
         515                520                525
Arg Thr Gly Ala Arg Gly Val Phe Pro Ala Tyr Tyr Ala Ile Glu Val 
     530                535                540
Thr Lys Glu Pro Glu His Met Ala Ala Leu Ala Lys Asn Ser Asp Trp 
 545                550                555                560
Ile Asp Gln Phe Arg Val Lys Phe Leu Gly Ser Val Gln Val Pro Tyr 
                 565                570                575
His Lys Gly Asn Asp Val Leu Cys Ala Ala Met Gln Lys Ile Ala Thr 
             580                585                590
Thr Arg Arg Leu Thr Val His Phe Asn Pro Pro Ser Ser Cys Val Leu 
         595                600                605
Glu Ile Ser Val Arg Gly Val Lys Ile Gly Val Lys Ala Asp Glu Ala 
     610                615                620
Gln Glu Ala Lys Gly Asn Lys Cys Ser His Phe Phe Gln Leu Lys Asn 
 625                630                635                640
Ile Ser Phe Cys Gly Tyr His Pro Lys Asn Asn Lys Tyr Phe Gly Phe 
                 645                650                655
Ile Thr Lys His Pro Ala Asp His Arg Phe Ala Cys His Val Phe Val 
             660                665                670
Ser Glu Asp Ser Thr Lys Ala Leu Ala Glu Ser Val Gly Arg Ala Phe 
         675                680                685
Gln Gln Phe Tyr Lys Gln Phe Val Glu Tyr Thr Cys Pro Thr Glu Asp 
     690                695                700
Ile Tyr Leu Glu 
 705



<210> 1246
<211> 1510
<212> DNA
<213> Homo sapiens
<308> AF007134
<400> 1246

gccgctccc  ctcctccag  gctgagtcc  tcgggctgt  ctcctgcat  atcaacggg  60
aggagcagg  gcagaccca  cgggccata  tcaggtttg  gcctcgaca  gaagacgaa  120
ttgagctgg  agtggatga  cctctgcta  tggagctcc  ggctgaaga  tactggtac  180
aggcctaca  catgcgcac  ggtgcccgg  gtgtctttc  tgcctatta  gccatcgag  240
tcaccaagg  gcccgagca  atggcagcc  tggccaaaa  cagtgactg  gtggaccag  300
tccgggtga  gttcctggg  tcagtccag  ttccctatc  caagggcaa  gacgtcctc  360
gtgctgcta  gcaaaagat  gccaccacc  gccggctca  cgtgcactt  aacccgccc  420
ccagctgtg  cctggagat  agcgtgcgg  gtgtgaaga  aggcgtcaa  gccgatgac  480
cccaggagg  caaggggaa  aaatgtagc  actttttcc  gttaaaaaa  atctctttc  540
gcggatatc  tccaaagaa  aacaagtac  ttgggttca  caccaagca  cccgccgac  600
accggtttg  ctgccacgt  tttgtgtct  aagactcca  caaagccct  gcagagtcc  660
tggggagag  attccagca  ttctacaag  agtttgtgg  gtacacctg  cccacagaa  720
atatctacc  ggagtagct  tgcagcccc  ccctctgcg  cccccagcc  tcaggccag  780
gccaggaca  ctggctgct  acaggatgt  gcactgctt  aggaggggc  cctgccacc  840
ccagaggac  aggaagtgg  ggccgctgg  ccagggtag  ggagggtgg  gcaatgggg  900
gaggcaaat  cagtttatt  taatatatg  gattagatt  atctatgga  ggcagagtg  960
gctgcctgg  gattgggag  gacagggct  ggggagcag  tctctggca  agaaggatg  1020
ccgttccag  agcacacgg  cctgcccca  cctgggcct  acctcccct  ccagggctc  1080
ggcgctgtg  ctcctgcct  gatgaagcc  gtgtcctgc  ttgatgaag  ctgtgccac  1140
tgcaagtgc  cgccctgcc  ctgccccaa  ccccaccga  gagccctga  ctcaggctg  1200
gcccagcca  ctcccaagg  ctttccagt  aggaaatgg  aacacgtgg  ggtgaagtc  1260
ctgttctca  ctccgtcat  tgcggggct  ctgggtggc  cctgccact  acctcaccg  1320
catgctggc  tgtggcagg  ctaggacct  aggcgggga  gaggagctg  cgcaaggcc  1380
tgtcccagc  gaagaggga  gcttcctga  tgacacagg  cagccccat  ttggtcctg  1440
caccctggc  ccaactatt  aagtgccat  tcctgtctg  aaaaaaaaa  aaaaaaaaa  1500
aaaaaaaaaa  1510



<210> 1247
<211> 711
<212> PRT
<213> Homo sapiens
<308> Q9UQF2
<400> 1247

Met Ala Glu Arg Glu Ser Gly Gly Leu Gly Gly Gly Ala Ala Ser Pro 
  1               5                  10                  15
Pro Ala Ala Ser Pro Phe Leu Gly Leu His Ile Ala Ser Pro Pro Asn 
             20                  25                  30
Phe Arg Leu Thr His Asp Ile Ser Leu Glu Glu Phe Glu Asp Glu Asp 
         35                  40                  45
Leu Ser Glu Ile Thr Asp Glu Cys Gly Ile Ser Leu Gln Cys Lys Asp 
     50                  55                  60
Thr Leu Ser Leu Arg Pro Pro Arg Ala Gly Leu Leu Ser Ala Gly Gly 
 65                  70                  75                  80
Gly Gly Ala Gly Ser Arg Leu Gln Ala Glu Met Leu Gln Met Asp Leu 
                 85                  90                  95
Ile Asp Ala Thr Gly Asp Thr Pro Gly Ala Glu Asp Asp Glu Glu Asp 
             100                105                110
Asp Asp Glu Glu Arg Ala Ala Arg Arg Pro Gly Ala Gly Pro Pro Lys 
         115                120                125
Ala Glu Ser Gly Gln Glu Pro Ala Ser Arg Gly Gln Gly Gln Ser Gln 
     130                135                140
Gly Gln Ser Gln Gly Pro Gly Ser Gly Asp Thr Tyr Arg Pro Lys Arg 
 145                150                155                160
Pro Thr Thr Leu Asn Leu Phe Pro Gln Val Pro Arg Ser Gln Asp Thr 
                 165                170                175
Leu Asn Asn Asn Ser Leu Gly Lys Lys His Ser Trp Gln Asp Arg Val 
             180                185                190
Ser Arg Ser Ser Ser Pro Leu Lys Thr Gly Glu Gln Thr Pro Pro His 
         195                200                205
Glu His Ile Cys Leu Ser Asp Glu Leu Pro Pro Gln Ser Gly Pro Ala 
     210                215                220
Pro Thr Thr Asp Arg Gly Thr Ser Thr Asp Ser Pro Cys Arg Arg Ser 
 225                230                235                240
Thr Ala Thr Gln Met Ala Pro Pro Gly Gly Pro Pro Ala Ala Pro Pro 
                 245                250                255
Gly Gly Arg Gly His Ser His Arg Asp Arg Ile His Tyr Gln Ala Asp 
             260                265                270
Val Arg Leu Glu Ala Thr Glu Glu Ile Tyr Leu Thr Pro Val Gln Arg 
         275                280                285
Pro Pro Asp Ala Ala Glu Pro Thr Ser Ala Phe Leu Pro Pro Thr Glu 
     290                295                300
Ser Arg Met Ser Val Ser Ser Asp Pro Asp Pro Ala Ala Tyr Pro Ser 
 305                310                315                320
Thr Ala Gly Arg Pro His Pro Ser Ile Ser Glu Glu Glu Glu Gly Phe 
                 325                330                335
Asp Cys Leu Ser Ser Pro Glu Arg Ala Glu Pro Pro Gly Gly Gly Trp 
             340                345                350
Arg Gly Ser Leu Gly Glu Pro Pro Pro Pro Pro Arg Ala Ser Leu Ser 
         355                360                365
Ser Asp Thr Ser Ala Leu Ser Tyr Asp Ser Val Lys Tyr Thr Leu Val 
     370                375                380
Val Asp Glu His Ala Gln Leu Glu Leu Val Ser Leu Arg Pro Cys Phe 
 385                390                395                400
Gly Asp Tyr Ser Asp Glu Ser Asp Ser Ala Thr Val Tyr Asp Asn Cys 
                 405                410                415
Ala Ser Val Ser Ser Pro Tyr Glu Ser Ala Ile Gly Glu Glu Tyr Glu 
             420                425                430
Glu Ala Pro Arg Pro Gln Pro Pro Ala Cys Leu Ser Glu Asp Ser Thr 
         435                440                445
Pro Asp Glu Pro Asp Val His Phe Ser Lys Lys Phe Leu Asn Val Phe 
     450                455                460
Met Ser Gly Arg Ser Arg Ser Ser Ser Ala Glu Ser Phe Gly Leu Phe 
 465                470                475                480
Ser Cys Ile Ile Asn Gly Glu Glu Gln Glu Gln Thr His Arg Ala Ile 
                 485                490                495
Phe Arg Phe Val Pro Arg His Glu Asp Glu Leu Glu Leu Glu Val Asp 
             500                505                510
Asp Pro Leu Leu Val Glu Leu Gln Ala Glu Asp Tyr Trp Tyr Glu Ala 
         515                520                525
Tyr Asn Met Arg Thr Gly Ala Arg Gly Val Phe Pro Ala Tyr Tyr Ala 
     530                535                540
Ile Glu Val Thr Lys Glu Pro Glu His Met Ala Ala Leu Ala Lys Asn 
 545                550                555                560
Ser Asp Trp Val Asp Gln Phe Arg Val Lys Phe Leu Gly Ser Val Gln 
                 565                570                575
Val Pro Tyr His Lys Gly Asn Asp Val Leu Cys Ala Ala Met Gln Lys 
             580                585                590
Ile Ala Thr Thr Arg Arg Leu Thr Val His Phe Asn Pro Pro Ser Ser 
         595                600                605
Cys Val Leu Glu Ile Ser Val Arg Gly Val Lys Ile Gly Val Lys Ala 
     610                615                620
Asp Asp Ser Gln Glu Ala Lys Gly Asn Lys Cys Ser His Phe Phe Gln 
 625                630                635                640
Leu Lys Asn Ile Ser Phe Cys Gly Tyr His Pro Lys Asn Asn Lys Tyr 
                 645                650                655
Phe Gly Phe Ile Thr Lys His Pro Ala Asp His Arg Phe Ala Cys His 
             660                665                670
Val Phe Val Ser Glu Asp Ser Thr Lys Ala Leu Ala Glu Ser Val Gly 
         675                680                685
Arg Ala Phe Gln Gln Phe Tyr Lys Gln Phe Val Glu Tyr Thr Cys Pro 
     690                695                700
Thr Glu Asp Ile Tyr Leu Glu 
 705                710



<210> 1248
<211> 1660
<212> DNA
<213> Rattus norvegicus
<308> AF092523
<400> 1248

atggcaatc  agttccgct  actcttccc  ttggccttg  ctggaatgc  agcactcct  60
ggctggtgg  ggtttttct  tcgtaaaaa  gatcggctc  gcagcaatg  caagcaggt  120
gggacattg  aggttggcc  tgccatcga  gaccgactg  ccactgaag  ggcctgtcc  180
ggagtcctg  ctgtgaccc  cagtgtcac  cagcctcct  gaaaggaag  gcagcgctc  240
atggacagg  ctctttcag  tcccccagc  ttgccaagg  cccgtcaag  tcgccgaag  300
tcagagtcc  caggcaacc  ccccagcat  gtagacaca  ggttgcagg  aggacagtg  360
agcgatgag  attcaaaag  ggtactctc  ctgatgggg  acgaagcca  atctattcc  420
cttggacgt  cgcttttcc  aaaggatct  tccttcccc  atgaagcag  ggaagggtg  480
aagcaagag  ctgccctgg  cagaactcc  gggagaggc  ggctaagcc  gtgtgcagc  540
tctggagag  acgcgagag  gacgggtgg  gcggaaggg  ctggagatg  tgtgttggg  600
gaaagtgta  ttgaggaag  cctattgcc  caggagtgt  tttcagaag  agagaagag  660
gagtttccg  tcctagctc  cgggggagg  gggggagag  aggtgagaa  tggcccacc  720
caggtagat  agcttttaa  gaaggaaga  tatattgtt  ggaagttgc  aagtagctt  780
gtggggcca  ttcactcgg  gctggttaa  gatgagggt  cgctggtac  ccaagtcaa  840
ggtagccag  acagaagcc  ggctagaga  ctggacaaa  acaagacct  gcctgaaaa  900
gaccagatt  agcagactg  cttccagat  acctcccag  tgatcttgg  agcgactga  960
gagatacgg  ccaccacag  gggcaagac  gtggcacaa  tgcatccaa  cccgggcac  1020
cagcctcag  ggcaggagg  gagctgtgt  ccagccagc  aggaaacta  cttgggaca  1080
gaaatccca  atcctgctt  caccagaac  ggtgccact  ccagccctt  agcaggagc  1140
ccaccacca  agacctatg  gagctgtct  agcagtcct  tgtcaggcc  caccaagga  1200
cagaagcca  agaactctg  acaccacat  tccctggct  cctgcccac  gccagttac  1260
ccccagagg  agtctctgg  tggggcaag  aacccgaga  gtgatgaca  ctttgccac  1320
tgtacgtcc  acaacagcc  gagtgtcct  tcagttacc  ccttggggc  gtgctcaga  1380
cctgtcagt  cttcgaggc  tgaagactc  tgcacagag  ccatctcaa  ctccggaga  1440
aaagctgtc  ccccaccac  gccagacag  actgagccc  tcagcaatg  ggtgctgaa  1500
gaggagttg  cagacttgg  gaccgagga  ggatggacc  tggatacag  agcagatca  1560
tcaggagtt  cagctccac  ccaggaaag  gggcacttt  gtaacggag  gtgcgctgg  1620
tttttcgag  gctgacccc  gcgtagaca  ttcagaccgc  1660



<210> 1249
<211> 854
<212> PRT
<213> Rattus norvegicus
<308> O88884
<400> 1249

Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
  1               5                  10                  15
Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys Lys Asp Arg 
             20                  25                  30
Leu Ser Ser Asn Gly Lys Gln Val Gly Thr Leu Lys Val Gly Pro Ala 
         35                  40                  45
Ile Glu Asp Arg Leu Pro Thr Glu Glu Ala Cys Pro Gly Val Leu Ser 
     50                  55                  60
Val Thr Pro Ser Val Thr Gln Pro Pro Gly Lys Glu Glu Gln Arg Ser 
 65                  70                  75                  80
Met Asp Arg Pro Leu Ser Asp Pro Pro Ala Leu Pro Arg Thr Arg Gln 
                 85                  90                  95
Val Arg Arg Arg Ser Glu Ser Ser Gly Asn Leu Pro Ser Ile Val Asp 
             100                105                110
Thr Arg Leu Gln Ala Gly Gln Cys Ser Asp Glu Asn Ser Lys Val Val 
         115                120                125
Leu Ser Leu Met Gly Asp Glu Ala Lys Ser Ile Pro Leu Gly Arg Pro 
     130                135                140
Leu Phe Pro Lys Asp Leu Ser Phe Pro Tyr Glu Ala Val Glu Gly Cys 
 145                150                155                160
Lys Gln Glu Ser Ala Leu Gly Arg Thr Pro Gly Arg Gly Trp Leu Ser 
                 165                170                175
Gln Cys Ala Ala Ser Gly Glu Asn Ala Arg Glu Thr Gly Gly Ala Glu 
             180                185                190
Gly Thr Gly Asp Ala Val Leu Gly Glu Ser Val Leu Glu Glu Gly Leu 
         195                200                205
Leu Pro Gln Glu Cys Val Ser Glu Val Glu Lys Ser Glu Phe Pro Ile 
     210                215                220
Leu Ala Pro Gly Gly Gly Gly Gly Glu Lys Val Arg Ser Gly Pro Pro 
 225                230                235                240
Gln Val Asp Glu Leu Leu Lys Lys Glu Glu Tyr Ile Val Gly Lys Leu 
                 245                250                255
Pro Ser Ser Phe Val Gly Pro Val His Ser Glu Leu Val Lys Asp Glu 
             260                265                270
Gly Ala Leu Val Pro Gln Val Lys Gly Ser Gln Asp Arg Ser Leu Ala 
         275                280                285
Arg Glu Leu Asp Lys Asp Lys Thr Leu Pro Glu Lys Asp Gln Ile Glu 
     290                295                300
Gln Thr Ala Phe Gln Ile Ile Ser Gln Val Ile Leu Glu Ala Thr Glu 
 305                310                315                320
Glu Ile Arg Ala Thr Thr Val Gly Lys Thr Val Ala Gln Val His Pro 
                 325                330                335
Thr Pro Gly Thr Gln Pro Gln Gly Gln Glu Glu Ser Cys Val Pro Ala 
             340                345                350
Ser Gln Glu Thr Ser Leu Gly Gln Glu Ile Pro Asp Pro Ala Ser Thr 
         355                360                365
Arg Thr Gly Ala Thr Ala Ser Pro Ser Ala Gly Ala Pro Pro Pro Lys 
     370                375                380
Thr Tyr Val Ser Cys Leu Ser Ser Pro Leu Ser Gly Pro Thr Lys Asp 
 385                390                395                400
Gln Lys Pro Lys Asn Ser Ala His His Ile Ser Leu Ala Pro Cys Pro 
                 405                410                415
Pro Pro Val Thr Pro Gln Arg Gln Ser Leu Asp Gly Ala Ser Asn Pro 
             420                425                430
Arg Gly Asp Asp Thr Phe Val Thr Cys Thr Ser Asn Asn Ser Gln Ser 
         435                440                445
Val Leu Ser Val Thr Ser Leu Gly Leu Cys Ser Asp Pro Val Ser Thr 
     450                455                460
Ser Arg Leu Glu Asp Ser Cys Thr Glu Thr Ile Ser Ser Ser Gly Asp 
 465                470                475                480
Lys Ala Val Thr Pro Pro Leu Pro Asp Ser Thr Glu Pro Phe Ser Asn 
                 485                490                495
Gly Val Leu Lys Glu Glu Leu Ser Asp Leu Gly Thr Glu Asp Gly Trp 
             500                505                510
Thr Met Asp Thr Glu Ala Asp His Ser Gly Gly Ser Asp Gly Asn Ser 
         515                520                525
Met Asp Ser Val Asp Ser Cys Cys Gly Leu Thr Lys Pro Asp Ser Pro 
     530                535                540
Gln Thr Val Gln Ala Gly Ser Asn Pro Lys Lys Val Asp Leu Ile Ile 
 545                550                555                560
Trp Glu Ile Glu Val Pro Lys His Leu Val Gly Arg Leu Ile Gly Lys 
                 565                570                575
Gln Gly Arg Tyr Val Ser Phe Leu Lys Gln Thr Ser Gly Ala Lys Ile 
             580                585                590
Tyr Ile Ser Thr Leu Pro Tyr Thr Gln Asn Ile Gln Ile Cys His Ile 
         595                600                605
Glu Gly Ser Gln His His Val Asp Lys Ala Leu Asn Leu Ile Gly Lys 
     610                615                620
Lys Phe Lys Glu Leu Asn Leu Thr Asn Ile Tyr Ala Pro Pro Leu Pro 
 625                630                635                640
Ser Leu Ala Leu Pro Ser Leu Pro Met Thr Ser Trp Leu Met Leu Pro 
                 645                650                655
Asp Gly Ile Thr Val Glu Val Ile Val Val Asn Gln Val Asn Ala Gly 
             660                665                670
His Leu Phe Val Gln Gln His Thr His Pro Thr Phe His Ala Leu Arg 
         675                680                685
Ser Leu Asp Gln Gln Met Tyr Leu Cys Tyr Ser Gln Pro Gly Ile Pro 
     690                695                700
Thr Leu Pro Thr Pro Val Glu Ile Thr Val Ile Cys Ala Ala Pro Gly 
 705                710                715                720
Ala Asp Gly Ala Trp Trp Arg Ala Gln Val Val Ala Ser Tyr Glu Glu 
                 725                730                735
Thr Asn Glu Val Glu Ile Arg Tyr Val Asp Tyr Gly Gly Tyr Lys Arg 
             740                745                750
Val Lys Val Asp Val Leu Arg Gln Ile Arg Ser Asp Phe Val Thr Leu 
         755                760                765
Pro Phe Gln Gly Ala Glu Val Leu Leu Asp Ser Val Val Pro Leu Ser 
     770                775                780
Asp Asp Asp His Phe Ser Pro Glu Ala Asp Ala Ala Met Ser Glu Met 
 785                790                795                800
Thr Gly Asn Thr Ala Leu Leu Ala Gln Val Thr Ser Tyr Ser Ala Thr 
                 805                810                815
Gly Leu Pro Leu Ile Gln Leu Trp Ser Val Val Gly Asp Glu Val Val 
             820                825                830
Leu Ile Asn Arg Ser Leu Val Glu Arg Gly Leu Ala Gln Trp Val Asp 
         835                840                845
Ser Cys Tyr Ala Ser Leu 
     850



<210> 1250
<211> 3149
<212> DNA
<213> Homo sapiens
<308> BC000729
<400> 1250

ggcacgagg  tgtgttcca  ccgcctggg  tagcacgtg  gggagctgc  gaagcgcgg  60
gctgcgggc  gggccgcgg  gcacagccg  gggccggcg  cggcgcgcg  actccgcat  120
ccgcacccc  atggtagcc  aggagctgg  gtaattact  caagcctcc  ggatggcaa  180
ccagttccg  tcgctcttc  ccttggcat  gcctgggat  ctggcgctc  tcggctggt  240
gtggttttt  tctcgtaaa  aaggccatg  cagcagcca  gatgagcag  aggtggagg  300
tggtgctgt  cagctgagg  ctgaccctg  catcaagga  cctctcccc  tggaagacg  360
ctgtcccaa  gtagtgtcc  cacccccca  tgtcacaga  cctccagaa  aggaactgt  420
caccgtgag  aagctgcct  cagagcccc  agcattgct  cagacacac  caccttgcc  480
aagatcaga  tcctcgggc  ttcttccta  caccacaga  atgagattg  gaccaggaa  540
acgcagaga  gacagtaca  agctggagc  agccctgac  ggtggtgaa  ccaaatcga  600
tcctctaga  tgccccctt  catccccaa  gggtgtact  ttctccagc  aatcagctg  660
ggtgtgtaa  caagattcc  ccttcagca  ggtgccaag  aaggtccag  caggctacc  720
cgtagtccc  gcagagaag  gtagctctg  ggagagggc  agagagaca  gtggggccg  780
agggactgg  gatgccgtg  tgggggaaa  ggtgcttga  gaagctctg  tgtctcggg  840
gcatgtctt  gaattggag  acagcaagg  ccccagcct  gcctcttta  agggggaag  900
agataaggg  aagagcagc  catcccagg  ggtggggcc  gtgcaggag  aagagtatg  960
agcagagaa  ttgccaagt  ggttcatcg  gtcggctca  acagagctg  caaaggacg  1020
tgcggcgcc  gcaccccca  tcgcagacg  caaagccca  gatagaggt  tcgagggag  1080
actgggcaa  gaggagagc  tggatagaa  tgaggaggg  ttggataga  atgaggagg  1140
cttggatag  aatgaggag  gcttggata  aaatgagga  ggcttggat  gaaatgagg  1200
gattaagcg  gctgccttc  agataatct  ccaagtgat  tcagaagca  ccgaacagg  1260
gctggccac  acggttggc  aggttgcag  tcgtgtgtg  caggccagt  agctccaag  1320
gcagaagga  gagagctgt  tcccagttc  ccagaaaac  gtcttgggc  cagacactg  1380
ggagcctgc  acagcagag  cagctgttg  cccgccgga  gctggcctc  ccttgccag  1440
cctaccagc  gagggctca  caccaccaa  gacctacgt  agctgcctg  agagccttc  1500
gtccagccc  accaaggac  gtaagccaa  tatctctgc  caccacatc  ccctggcct  1560
ctgcctggc  ctgaccacc  ccagtgaag  gttgccgga  cgggcaggc  tcctggtgg  1620
agatgccac  tgtgtcacc  gcatgtcag  cagcagcca  agtgtccct  tggtggctt  1680
tccaggaca  tgctcagat  ctttcagca  ttcagggct  gaagactct  gcacagaga  1740
cagctcgag  cccagggac  aggccatca  cccgccact  ccagaaagt  ctgtgccct  1800
cagcaatgg  gtgctgaag  gggagttgt  agacttggg  gctgaggat  gatggacca  1860
ggatgcgga  gcagatcat  caggaggtt  tgacaggaa  agcatggat  ccgtggata  1920
ctgttgcag  ctcaagaag  ctgagagct  ccaaaatgc  caggcaggc  ccaacccta  1980
gaaggtcga  ctcatcatc  gggagatcg  ggtgccaaa  cacttagtc  gtcggctaa  2040
tggcaagca  gggcgctat  tgagttttc  gaagcaaac  tctggtgcc  agatctaca  2100
ttcaaccct  ccttacacc  agagcgtcc  gatctgcca  atagaaggc  ctcaacatc  2160
tgtagacaa  gcgctgaac  tgattggga  gaagttcaa  gagctgaac  tcaccaata  2220
ctacgctcc  ccattgcct  cactggcac  gccttctct  ccgatgaca  cctggctca  2280
gctgcctga  ggcatcacc  tggaggtca  tgtggtcaa  caggtcaat  ccgggcacc  2340
gttcgtgca  cagcacaca  accctacct  ccacgcgct  cgcagcctc  accagcaga  2400
gtacctctg  tactctcag  ctggaatcc  caccttgcc  accccagtg  aaataacgg  2460
catctgtgc  gcccctggt  cggacgggg  ctggtggcg  gcccaagtg  ttgcctcct  2520
cgaggagac  aacgaagtg  agattcgat  cgtgcacta  ggcggatat  agagggtga  2580
agtagacgt  ctccggcaa  tcaggtctg  ctttgtcac  ctgccgttt  agggagcag  2640
agtccttct  gacagtgtg  tgcccctgt  agacgatga  cagttttca  cggaagcag  2700
tgccgccat  agcgagatg  cggggaata  agcactgct  gctcaggtg  caagttaca  2760
tccaactgg  cttcctctg  ttcagctgt  gagtgtggt  ggagatgaa  tggtgttga  2820
aaaccggtc  ctggtggag  gaggccttg  ccagtgggt  gacagctac  acacaagcc  2880
ttgaccccc  tgctgcttc  tgagagtct  tttttgcac  gttgaaatt  ggcttggca  2940
tcaagtcaa  gatgaacat  ggaataaca  acattgtcc  ctccagaaa  tcctttctt  3000
ctccatact  tagtcctat  gagaagaca  ttcgtctct  agaaaaaag  atggaacta  3060
gggttctct  cgcaaagcc  aaggatagt  tttaacaag  cagctggct  atgctggtt  3120
tcagctgtt  aaaaaaaaa  aaaaaaaaa  3149



<210> 1251
<211> 903
<212> PRT
<213> Homo sapiens
<308> Q92667
<400> 1251

Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
  1               5                  10                  15
Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys Lys Gly His 
             20                  25                  30
Val Ser Ser His Asp Glu Gln Gln Val Glu Ala Gly Ala Val Gln Leu 
         35                  40                  45
Arg Ala Asp Pro Ala Ile Lys Glu Pro Leu Pro Val Glu Asp Val Cys 
     50                  55                  60
Pro Lys Val Val Ser Thr Pro Pro Ser Val Thr Glu Pro Pro Glu Lys 
 65                  70                  75                  80
Glu Leu Ser Thr Val Ser Lys Leu Pro Ala Glu Pro Pro Ala Leu Leu 
                 85                  90                  95
Gln Thr His Pro Pro Cys Arg Arg Ser Glu Ser Ser Gly Ile Leu Pro 
             100                105                110
Asn Thr Thr Asp Met Arg Leu Arg Pro Gly Thr Arg Arg Asp Asp Ser 
         115                120                125
Thr Lys Leu Glu Leu Ala Leu Thr Gly Gly Glu Ala Lys Ser Ile Pro 
     130                135                140
Leu Glu Cys Pro Leu Ser Ser Pro Lys Gly Val Leu Phe Ser Ser Lys 
 145                150                155                160
Ser Ala Glu Val Cys Lys Gln Asp Ser Pro Phe Ser Arg Val Pro Arg 
                 165                170                175
Lys Val Gln Pro Gly Tyr Pro Val Val Pro Ala Glu Lys Arg Ser Ser 
             180                185                190
Gly Glu Arg Ala Arg Glu Thr Gly Gly Ala Glu Gly Thr Gly Asp Ala 
         195                200                205
Val Leu Gly Glu Lys Val Leu Glu Glu Ala Leu Leu Ser Arg Glu His 
     210                215                220
Val Leu Glu Leu Glu Asn Ser Lys Gly Pro Ser Leu Ala Ser Leu Glu 
 225                230                235                240
Gly Glu Glu Asp Lys Gly Lys Ser Ser Ser Ser Gln Val Val Gly Pro 
                 245                250                255
Val Gln Glu Glu Glu Tyr Val Ala Glu Lys Leu Pro Ser Arg Phe Ile 
             260                265                270
Glu Ser Ala His Thr Glu Leu Ala Lys Asp Asp Ala Ala Pro Ala Pro 
         275                280                285
Pro Val Ala Asp Ala Lys Ala Gln Asp Arg Gly Val Glu Gly Glu Leu 
     290                295                300
Gly Asn Glu Glu Ser Leu Asp Arg Asn Glu Glu Gly Leu Asp Arg Asn 
 305                310                315                320
Glu Glu Gly Leu Asp Arg Asn Glu Glu Ser Leu Asp Arg Asn Glu Glu 
                 325                330                335
Gly Leu Asp Arg Asn Glu Glu Ile Lys Arg Ala Ala Phe Gln Ile Ile 
             340                345                350
Ser Gln Val Ile Ser Glu Ala Thr Glu Gln Val Leu Ala Thr Thr Val 
         355                360                365
Gly Lys Val Ala Gly Arg Val Cys Gln Ala Ser Gln Leu Gln Gly Gln 
     370                375                380
Lys Glu Glu Ser Cys Val Pro Val His Gln Lys Thr Val Leu Gly Pro 
 385                390                395                400
Asp Thr Ala Glu Pro Ala Thr Ala Glu Ala Ala Val Ala Pro Pro Asp 
                 405                410                415
Ala Gly Leu Pro Leu Pro Gly Leu Pro Ala Glu Gly Ser Pro Pro Pro 
             420                425                430
Lys Thr Tyr Val Ser Cys Leu Lys Ser Leu Leu Ser Ser Pro Thr Lys 
         435                440                445
Asp Ser Lys Pro Asn Ile Ser Ala His His Ile Ser Leu Ala Ser Cys 
     450                455                460
Leu Ala Leu Thr Thr Pro Ser Glu Glu Leu Pro Asp Arg Ala Gly Ile 
 465                470                475                480
Leu Val Glu Asp Ala Thr Cys Val Thr Cys Met Ser Asp Ser Ser Gln 
                 485                490                495
Ser Val Pro Leu Val Ala Ser Pro Gly His Cys Ser Asp Ser Phe Ser 
             500                505                510
Thr Ser Gly Leu Glu Asp Ser Cys Thr Glu Thr Ser Ser Ser Pro Arg 
         515                520                525
Asp Lys Ala Ile Thr Pro Pro Leu Pro Glu Ser Thr Val Pro Phe Ser 
     530                535                540
Asn Gly Val Leu Lys Gly Glu Leu Ser Asp Leu Gly Ala Glu Asp Gly 
 545                550                555                560
Trp Thr Met Asp Ala Glu Ala Asp His Ser Gly Gly Ser Asp Arg Asn 
                 565                570                575
Ser Met Asp Ser Val Asp Ser Cys Cys Ser Leu Lys Lys Thr Glu Ser 
             580                585                590
Phe Gln Asn Ala Gln Ala Gly Ser Asn Pro Lys Lys Val Asp Leu Ile 
         595                600                605
Ile Trp Glu Ile Glu Val Pro Lys His Leu Val Gly Arg Leu Ile Gly 
     610                615                620
Lys Gln Gly Arg Tyr Val Ser Phe Leu Lys Gln Thr Ser Gly Ala Lys 
 625                630                635                640
Ile Tyr Ile Ser Thr Leu Pro Tyr Thr Gln Ser Val Gln Ile Cys His 
                 645                650                655
Ile Glu Gly Ser Gln His His Val Asp Lys Ala Leu Asn Leu Ile Gly 
             660                665                670
Lys Lys Phe Lys Glu Leu Asn Leu Thr Asn Ile Tyr Ala Pro Pro Leu 
         675                680                685
Pro Ser Leu Ala Leu Pro Ser Leu Pro Met Thr Ser Trp Leu Met Leu 
     690                695                700
Pro Asp Gly Ile Thr Val Glu Val Ile Val Val Asn Gln Val Asn Ala 
 705                710                715                720
Gly His Leu Phe Val Gln Gln His Thr His Pro Thr Phe His Ala Leu 
                 725                730                735
Arg Ser Leu Asp Gln Gln Met Tyr Leu Cys Tyr Ser Gln Pro Gly Ile 
             740                745                750
Pro Thr Leu Pro Thr Pro Val Glu Ile Thr Val Ile Cys Ala Ala Pro 
         755                760                765
Gly Ala Asp Gly Ala Trp Trp Arg Ala Gln Val Val Ala Ser Tyr Glu 
     770                775                780
Glu Thr Asn Glu Val Glu Ile Arg Tyr Val Asp Tyr Gly Gly Tyr Lys 
 785                790                795                800
Arg Val Lys Val Asp Val Leu Arg Gln Ile Arg Ser Asp Phe Val Thr 
                 805                810                815
Leu Pro Phe Gln Gly Ala Glu Val Leu Leu Asp Ser Val Met Pro Leu 
             820                825                830
Ser Asp Asp Asp Gln Phe Ser Pro Glu Ala Asp Ala Ala Met Ser Glu 
         835                840                845
Met Thr Gly Asn Thr Ala Leu Leu Ala Gln Val Thr Ser Tyr Ser Pro 
     850                855                860
Thr Gly Leu Pro Leu Ile Gln Leu Trp Ser Val Val Gly Asp Glu Val 
 865                870                875                880
Val Leu Ile Asn Arg Ser Leu Val Glu Arg Gly Leu Ala Gln Trp Val 
                 885                890                895
Asp Ser Tyr Tyr Thr Ser Leu 
             900



<210> 1252
<211> 3706
<212> DNA
<213> Rattus norvegicus
<308> AF093268
<400> 1252

gcggccgcg  cgactacgg  tgcgagaag  cgacagaag  gggctccgc  gatgctcct  60
gtgagaacg  atcgatcct  cccagcctt  tctgcctgc  ctccacctc  tctctgctc  120
gagtcttag  agaacgaac  ttcaaagga  agattccaa  gtggtgtgc  gtgcacatc  180
cgagcggct  gggtttgca  ttcgagatt  cttctttat  atttttttt  tttaatgta  240
gggagacag  ggaattgct  cccgtagaa  ttttattca  gtgcacgtc  cgttgggtt  300
cacgctcca  ccccaggga  ctggtgtgg  gaaatttga  cccaccgcc  tagcccaaa  360
gccgagtaa  ctggctgct  gagtgtcgt  gaagacgtg  gcgaaatga  cagcgaact  420
attttttat  agactcact  aagctggct  ttgcgtttt  ctacacgta  actaatttt  480
tggaatagt  aaagtgcta  attctccgc  caacctttt  aaattccaa  tgtttgaac  540
ttttggtgt  agcgcgagt  aaatcattt  accgacaag  actaactga  ttgtctgcc  600
cgttgagtt  cctccggaa  agatctcgg  ggtggaaaa  caactgcaa  ataacagac  660
gagaaaatt  cttggaagt  atttctgta  cataagagc  gaaacttca  agcaagttt  720
cattgggca  aatggggga  caacctatc  tcagcactc  agctcatgt  ttccagatc  780
acccaaaca  aaagaagaa  tgggtaccc  ccagcaagc  tgcagttac  gtgtcttat  840
tctatgaca  cacaaggaa  gtgtatagg  taatcagtc  agacggctc  aaggcaata  900
taaatagca  catcactcc  aacatgaca  ttactaaaa  atctcaaaa  tttggccaa  960
gggctgata  ccgggcaaa  actgtttat  gactgggat  ctcctctga  catcatctc  1020
caaaatttg  agaaaagtt  caggaattt  aagaagctg  tcggctggc  aaggagaag  1080
cgcaggaga  gatggaact  accagtacc  cttcacagg  atcagcagg  ggagatctt  1140
agtctcctt  aacaccaga  agtatcaat  ggacagatg  tgagagaac  cccgatgtg  1200
cacagaact  agagccaag  gctgagcca  ctcagaatg  attgccatt  tcacatagt  1260
ccggggatc  aacccaggg  ctctctcat  ctagttcag  catcagcaa  cactgggag  1320
ctgaactag  cacgctcaa  gggaacaat  ccaagctca  cgcagcgct  ctggagtcc  1380
ctgccaacg  gaagcagtg  aagcaacag  tggctgcct  ccaggagga  gcagagcgg  1440
tgcacaagc  ggtcacgga  ctggaatgt  ttagtagtc  agcaaacgc  gtgcacagc  1500
acaagacag  gctgagtca  acagtgcag  agctggaag  gaccctaaa  gtaaaggaa  1560
aggaaatag  aagattaaa  caagaaatt  ataacgcca  agaacttca  gaacagagg  1620
actctttga  tcagaaact  caggaagtt  agattcgaa  taaagacct  gaggggcag  1680
tgtcggagc  ggagcagcg  ctggagaag  gccagagcg  gcaggacgc  ttccgcagt  1740
acctgaaga  tctcctaga  attctggac  ggaaaatat  tgaactaac  gaattgcgg  1800
ataatttgg  caagctact  gaatgcagc  aaagaaagt  aaatttcag  gccaataga  1860
gaagagata  tgtctgtct  cgtaggact  tttgggctc  gtaccaaga  tgcaaaaaa  1920
tttttgaat  tcattcctc  agaaggagg  tgttttgaa  attggaatt  tatatttca  1980
tataaattt  agaatttag  ttatagcta  ttgggggaa  aaaagacat  aaaaacttg  2040
accacaaat  atgcaatct  ttcccctga  agtagccaa  gggagaatt  acaatgtct  2100
ggtcccttc  cctttttct  ttcaacaca  tgaagatta  ctgcttttt  aatttattt  2160
cgatatcta  agctgtgtt  tgtgtaaaa  cttagtaat  gaagccctg  ctttgttgt  2220
atctgaata  tttctcagg  tattttttt  ctgctgaga  agggccatt  ccaattaat  2280
cttgccagg  gttggggag  tatgtctct  attggaatc  ctataactg  gtgtctgga  2340
ttcttccct  ttcgtactg  gagtgttct  actctagtg  ctactctgg  acactccgt  2400
ttctccaat  ttgtctgtt  tactttact  ttccatatt  actccatgt  tttatgaga  2460
gatattatc  cccatttta  tatacattt  gaagccaac  aaacaaagg  agctgagtc  2520
ttcagatat  tttcttttt  aatttatag  aaatttgac  cagaactga  attcagcag  2580
ccgtctttg  cggtttagt  tagcaatgt  aaggatatt  agagaaaat  tgcagttac  2640
tttatttat  tatttggca  gaaattttt  ctggatgat  aatgctttt  aatttatga  2700
aaataatgg  taggggcgc  gtttattat  gataatttt  aggtgtata  ctgttttca  2760
ggaggtcca  tcccgtcta  cagccaagc  gaggactgt  tctaaatcg  gatcgtggc  2820
gatgggtct  catagaaac  atgtcttta  tcaaacttc  tagggcaat  ttttgaact  2880
ttacctagg  atttcaaaa  aggaaatac  gtcaacaga  tcttctcca  gagcaggtt  2940
tactgttgt  ttgatgtaa  tttaagaca  ttagcaaac  tgcatttct  tatatgata  3000
atttctttc  caaaacaat  taaaagtaa  ccacgtgct  tctgctctg  ccgggtagg  3060
attgcatca  aatacatat  tcttgctgt  caatgcctg  gatattgaa  agggttctt  3120
tcatgtatg  ttgagtatc  aactctgga  tcaatgaat  cactgactt  tttttttgt  3180
cgtacccca  atgattgaa  tgttaagta  aaattaagc  gattaactc  ttttttcac  3240
cataaacag  ttcttagta  tagttttgt  ttatattta  gtgtatgta  gtaaataca  3300
acatattaa  ttatattag  gtgaaaaat  aattgtttg  ttctaacat  agtttctac  3360
gtaaggtgt  tctgaaaca  gtgtgtcag  cacttagcc  ccatgcatt  tatgtgcta  3420
cccatcatg  cagtcacct  catcgacgt  agggtattt  ccttacctg  ctattataa  3480
gagaataac  taggtacac  tgctcagag  cgagatatt  ctctgataa  tcaggtaat  3540
aaatctatt  gatgggtag  attttgaaa  cagacatga  tttatctat  agtttctga  3600
tatcaaaga  caccaggtt  tcatttaaa  agaggtcta  cactaggga  cagggaatt  3660
agttatgaa  agttgaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaa  3706



<210> 1253
<211> 366
<212> PRT
<213> Rattus norvegicus
<308> AAC71032
<400> 1253

Met Gly Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val Phe Gln Ile 
  1               5                  10                  15
Asp Pro Asn Thr Lys Lys Asn Trp Val Pro Thr Ser Lys His Ala Val 
             20                  25                  30
Thr Val Ser Tyr Phe Tyr Asp Ser Thr Arg Asn Val Tyr Arg Ile Ile 
         35                  40                  45
Ser Leu Asp Gly Ser Lys Ala Ile Ile Asn Ser Thr Ile Thr Pro Asn 
     50                  55                  60
Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp Ala Asp Ser 
 65                  70                  75                  80
Arg Ala Asn Thr Val Tyr Gly Leu Gly Phe Ser Ser Glu His His Leu 
                 85                  90                  95
Ser Lys Phe Ala Glu Lys Phe Gln Glu Phe Lys Glu Ala Ala Arg Leu 
             100                105                110
Ala Lys Glu Lys Ser Gln Glu Lys Met Glu Leu Thr Ser Thr Pro Ser 
         115                120                125
Gln Glu Ser Ala Gly Gly Asp Leu Gln Ser Pro Leu Thr Pro Glu Ser 
     130                135                140
Ile Asn Gly Thr Asp Asp Glu Arg Thr Pro Asp Val Thr Gln Asn Ser 
 145                150                155                160
Glu Pro Arg Ala Glu Pro Ala Gln Asn Ala Leu Pro Phe Ser His Ser 
                 165                170                175
Ala Gly Asp Arg Thr Gln Gly Leu Ser His Ala Ser Ser Ala Ile Ser 
             180                185                190
Lys His Trp Glu Ala Glu Leu Ala Thr Leu Lys Gly Asn Asn Ala Lys 
         195                200                205
Leu Thr Ala Ala Leu Leu Glu Ser Thr Ala Asn Val Lys Gln Trp Lys 
     210                215                220
Gln Gln Leu Ala Ala Tyr Gln Glu Glu Ala Glu Arg Leu His Lys Arg 
 225                230                235                240
Val Thr Glu Leu Glu Cys Val Ser Ser Gln Ala Asn Ala Val His Ser 
                 245                250                255
His Lys Thr Glu Leu Ser Gln Thr Val Gln Glu Leu Glu Glu Thr Leu 
             260                265                270
Lys Val Lys Glu Glu Glu Ile Glu Arg Leu Lys Gln Glu Ile Asp Asn 
         275                280                285
Ala Arg Glu Leu Gln Glu Gln Arg Asp Ser Leu Thr Gln Lys Leu Gln 
     290                295                300
Glu Val Glu Ile Arg Asn Lys Asp Leu Glu Gly Gln Leu Ser Glu Leu 
 305                310                315                320
Glu Gln Arg Leu Glu Lys Ser Gln Ser Glu Gln Asp Ala Phe Arg Ser 
                 325                330                335
Asn Leu Lys Thr Leu Leu Glu Ile Leu Asp Gly Lys Ile Phe Glu Leu 
             340                345                350
Thr Glu Leu Arg Asp Asn Leu Ala Lys Leu Leu Glu Cys Ser 
         355                360                365



<210> 1254
<211> 1225
<212> DNA
<213> Homo sapiens
<308> Y17829
<400> 1254

agacggaga  attcctttg  aagttattc  gtagcataa  agctgaaac  tcagagcaa  60
ttttcattg  gcaaaatgg  ggaacaacc  atcttcagc  ctcgagctc  tgtcttcca  120
attgaccca  acacaaaga  gaactgggt  cccaccagc  agcatgcag  tactgtgtc  180
tatttctat  acagcacaa  aaatgtgta  aggataatc  gtttagatg  ctcaaaggc  240
ataataaat  gtaccatca  cccaaacat  acatttact  aaacatctc  gaagtttgg  300
cagtgggct  atagccggg  aaacaccgt  tatggattg  gattctcct  tgagcatca  360
ctttcgaaa  ttgcagaaa  gtttcagga  tttaaagaa  ctgctcgac  agcaaagga  420
aaatcacaa  agaagatgg  acttaccag  acaccttca  aggaatccg  aggcgggga  480
cttcagtct  ctttaacac  ggaaagtat  aacgggaca  atgatgaaa  aacacctga  540
gtgacacag  actcagagc  aagggctga  ccaactcag  atgcattgc  attttcaca  600
agttcagca  tcagcaaac  ttgggaggc  gaactggct  ccctcaaag  aaataatgc  660
aaactcact  cagccctgc  ggagtccac  gccaatgtg  aacaatgga  acagcaact  720
gctgcctat  aagaggaag  agaacgtct  cacaagcgg  tgactgaac  tgaatgtgt  780
agtagccaa  caaatgcag  acatactca  aagacagaa  taaatcaga  aatacaaga  840
ctggaagag  cactgaaac  gaaggaaga  gaaatagaa  ggttaaaac  agaaattga  900
aatgccaga  aactacaag  acagaggga  tctttgact  agaaactac  ggaagtaga  960
attcggaac  aagacctgg  gggacaact  tctgactta  agcaacgtc  ggagaaaag  1020
cagaatgaa  aagaagctt  tcgcaataa  ctgaagaca  tcttagaaa  tctggatgg  1080
aagatattt  aactaacag  attacgaga  aacttggcc  agctactag  atgcagcta  1140
ggaaagtga  atttcagtg  caattaatt  aaagataca  tgtctctct  cataggact  1200
tttaggctc  gcatcaaga  tgcac  1225



<210> 1255
<211> 354
<212> PRT
<213> Homo sapiens
<308> NP_004263
<400> 1255

Met Gly Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val Phe Gln Ile 
  1               5                  10                  15
Asp Pro Asn Thr Lys Lys Asn Trp Val Pro Thr Ser Lys His Ala Val 
             20                  25                  30
Thr Val Ser Tyr Phe Tyr Asp Ser Thr Arg Asn Val Tyr Arg Ile Ile 
         35                  40                  45
Ser Leu Asp Gly Ser Lys Ala Ile Ile Asn Ser Thr Ile Thr Pro Asn 
     50                  55                  60
Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp Ala Asp Ser 
 65                  70                  75                  80
Arg Ala Asn Thr Val Tyr Gly Leu Gly Phe Ser Ser Glu His His Leu 
                 85                  90                  95
Ser Lys Phe Ala Glu Lys Phe Gln Glu Phe Lys Glu Ala Ala Arg Leu 
             100                105                110
Ala Lys Glu Lys Ser Gln Glu Lys Met Glu Leu Thr Ser Thr Pro Ser 
         115                120                125
Gln Glu Ser Ala Gly Gly Asp Leu Gln Ser Pro Leu Thr Pro Glu Ser 
     130                135                140
Ile Asn Gly Thr Asp Asp Glu Arg Thr Pro Asp Val Thr Gln Asn Ser 
 145                150                155                160
Glu Pro Arg Ala Glu Pro Thr Gln Asn Ala Leu Pro Phe Ser His Ser 
                 165                170                175
Ser Ala Ile Ser Lys His Trp Glu Ala Glu Leu Ala Thr Leu Lys Gly 
             180                185                190
Asn Asn Ala Lys Leu Thr Ala Ala Leu Leu Glu Ser Thr Ala Asn Val 
         195                200                205
Lys Gln Trp Lys Gln Gln Leu Ala Ala Tyr Gln Glu Glu Ala Glu Arg 
     210                215                220
Leu His Lys Arg Val Thr Glu Leu Glu Cys Val Ser Ser Gln Ala Asn 
 225                230                235                240
Ala Val His Thr His Lys Thr Glu Leu Asn Gln Thr Ile Gln Glu Leu 
                 245                250                255
Glu Glu Thr Leu Lys Leu Lys Glu Glu Glu Ile Glu Arg Leu Lys Gln 
             260                265                270
Glu Ile Asp Asn Ala Arg Glu Leu Gln Glu Gln Arg Asp Ser Leu Thr 
         275                280                285
Gln Lys Leu Gln Glu Val Glu Ile Arg Asn Lys Asp Leu Glu Gly Gln 
     290                295                300
Leu Ser Asp Leu Glu Gln Arg Leu Glu Lys Ser Gln Asn Glu Gln Glu 
 305                310                315                320
Ala Phe Arg Asn Asn Leu Lys Thr Leu Leu Glu Ile Leu Asp Gly Lys 
                 325                330                335
Ile Phe Glu Leu Thr Glu Leu Arg Asp Asn Leu Ala Lys Leu Leu Glu 
             340                345                350
Cys Ser 
         355



<210> 1256
<211> 2856
<212> DNA
<213> Rattus norvegicus
<308> AF095576
<400> 1256

ggcacgagc  aagagggag  gaacctcaa  gggcccgcc  cgggactgc  aagagcgca  60
gagcctcgc  gactgcagg  cagggaagc  ggagccagc  cccgccgcc  ccgccacca  120
cggccacca  gggcggagc  acggcccgg  gggccatgc  ccaccgggt  cgaggatcc  180
ggccgcggt  cgggcagcg  ttctccggc  ccccggccg  cgcggccga  gctgcgcgc  240
tgtagtccg  ggctgccat  ggaccaaag  catgaatgg  gccaccccc  gctcggcag  300
cgcccccgc  ccagtcccc  actggaggc  attctgcga  ctgcacgct  aggtagctg  360
tgtggactt  gctcacaag  tctgccgct  ccttcggga  aacccgacc  acgacacgc  420
tgacgctgg  acctcgttc  cccgccact  tgcagccaa  ttcttggca  tcttcagcg  480
ggaagtgcg  cgcgtgctg  ggacagcag  tgacaccat  gaacccgag  ctgcggtga  540
ctccgtgac  tcggcgctc  agactgcaa  ctatggcca  tctcgcagc  ccgaagatg  600
gtctgctca  gtggctacc  aggcccgtg  ccgcaaagg  ttctcactg  gtaacatga  660
cctgtgtgt  gtggacgga  tgcgcgacc  atggcaccg  cgcgcatcc  cagagcccg  720
gggtggggc  accccgaaa  ccaccgagc  tgtgtccga  cctcgtgac  aatggacgc  780
acgtctgcg  ctggcacga  ccctggcag  caaagtgga  ttagtggac  tccagcgcg  840
gggcgcact  cgcttcatg  tggcagatg  tgcagcctc  ggccctggg  gcacggcac  900
gtggcagaa  tgtcgcctg  tcctccgaa  ggctgtggc  ggagagcgc  tccgcctgg  960
gttcttcgt  ccacccaag  cttccagac  caaggtcag  atccccctg  cggccatca  1020
cgaggtccg  accaccatg  ccctggaaa  gcctgagaa  gacaacaca  ttgtgctca  1080
ggtggagaa  ggagcggag  acattctgg  gacgataga  tcactacag  agcactcgt  1140
ggtggctga  atccagggc  gtgtggatc  tggggacag  gaggaagac  cagggctgt  1200
ttgtgcacg  ggaggctgt  tggccagcc  cgtgacctc  tgcagctgt  agctcctga  1260
agaagcaga  atgccccgg  ccccagaga  gatgacagc  gtgggtgct  tggttacag  1320
tccacatgg  cgagctcgt  acaccgtgg  agagtccct  gctcacgtt  ccctggaga  1380
tttcctgca  accctggag  cttcaggtg  tgtcagtga  agcaataac  caggggatg  1440
aggagctga  ctggacccc  atgctgagg  tgagctgga  ctctccgac  acccctggt  1500
ccatgggac  ctgtcccgg  tgaaggccg  ccagctggt  ttggctggt  ggccccgga  1560
tcacggcct  tttgtgatc  gccaaagcg  gactcggcc  ggggagtgt  tgctgacct  1620
caacttcca  ggcaaggcc  agcaccttc  cctttctct  aatggtcac  gccagtgtc  1680
tgtccaaca  ctgtggttc  agtcggtgt  tgacatgct  cgacacttc  acacccacc  1740
cattcccct  gagtcagga  gatccgctg  catcaccct  cgaagctac  tgcgtgccc  1800
aggtccacc  cctgatcca  gaccagcgc  caacactgc  gccccggtc  cggcctgct  1860
gacggagcc  gctggccag  actacttct  cagcctggc  acggccacc  gcccaccca  1920
ttcaccctc  aatggcgct  gagcatcgt  gtcatccgg  tcatcatcc  ctgctacgt  1980
cgtgccccc  cgcccagcc  aggggccac  cagtgcgcg  agtcgcagc  acagcacag  2040
gcacctgct  gaggctgca  ccggagcca  tgaggagcc  gcagatgcc  cgctgggcc  2100
cgctcgcgc  gtggagaat  agtactcct  ttactagct  ccatgccta  tacccacgg  2160
tgtcacgca  aacacagca  gccacgaac  cctgctgtc  gtcctgccc  cccacagcc  2220
ggctagccc  tgacggtca  caacaccta  caaatggct  gacacacct  tccatggtc  2280
agcatggcc  agacagatg  ccagcctag  cacttcaaa  cccaggggc  cattatgac  2340
gtgtgtggc  ggccaaggc  aagtccatg  tcgatcaaa  ccatgatag  cctccaatg  2400
tttcacgcc  cgcccactg  tggttggcc  cgcccacca  cagctattt  tatacagtc  2460
atcgtatcc  cgacaggca  ctcactgac  actaaccac  tttggtgac  tcaggccct  2520
cctactgtt  gttggttac  cctacagtg  catcatggc  aacccactg  ctgcctgct  2580
tgctcgagg  tagcaagcc  cgtctatca  gcccatgaa  gcttaccca  tgattccta  2640
caacctcag  ccctgccca  ccatgttgg  tcacatact  caatagccc  ccaggctgt  2700
gtccgccta  cctaggaca  cctgtcacg  ccaccagcc  cagcccaac  ctgggggga  2760
aagccaagc  cttcagtga  gacaaacat  attaaagag  ctgttttag  gactaaaaa  2820
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaa  2856



<210> 1257
<211> 621
<212> PRT
<213> Rattus norvegicus
<308> AAC64408
<400> 1257

Met Asn Gly Ala Thr Pro Gly Ser Ala Ala Ala Pro Ala Pro Val Pro 
  1               5                  10                  15
Asp Trp Arg Gln Phe Cys Glu Leu His Ala Gln Val Ala Ala Val Asp 
             20                  25                  30
Phe Ala His Lys Phe Cys Arg Phe Leu Arg Asp Asn Pro Thr Tyr Asp 
         35                  40                  45
Thr Pro Asp Ala Gly Thr Ser Phe Ser Arg His Phe Ala Ala Asn Phe 
     50                  55                  60
Leu Ala Val Phe Ser Glu Glu Val Arg Arg Val Leu Gly Thr Ala Ala 
 65                  70                  75                  80
Asp Thr Met Glu Pro Glu Pro Ala Val Thr Ser Val Thr Ser Ala Leu 
                 85                  90                  95
Lys Thr Ala Thr Tyr Gly His Ser Arg Ser Ser Glu Asp Val Ser Ala 
             100                105                110
His Val Ala Thr Lys Ala Arg Val Arg Lys Gly Phe Ser Leu Arg Asn 
         115                120                125
Met Ser Leu Cys Val Val Asp Gly Val Arg Asp Leu Trp His Arg Arg 
     130                135                140
Ala Ser Pro Glu Pro Glu Gly Gly Ala Thr Pro Lys Thr Thr Glu Pro 
 145                150                155                160
Val Ser Glu Pro Arg Asp Lys Trp Thr Arg Arg Leu Arg Leu Ala Arg 
                 165                170                175
Thr Leu Ala Ala Lys Val Glu Leu Val Asp Ile Gln Arg Glu Gly Ala 
             180                185                190
Leu Arg Phe Met Val Ala Asp Asp Ala Ala Ser Gly Pro Gly Gly Thr 
         195                200                205
Ala Gln Trp Gln Lys Cys Arg Leu Leu Leu Arg Arg Ala Val Ala Gly 
     210                215                220
Glu Arg Phe Arg Leu Glu Phe Phe Val Pro Pro Lys Ala Ser Arg Pro 
 225                230                235                240
Lys Val Ser Ile Pro Leu Ser Ala Ile Ile Glu Val Arg Thr Thr Met 
                 245                250                255
Pro Leu Glu Met Pro Glu Lys Asp Asn Thr Phe Val Leu Lys Val Glu 
             260                265                270
Asn Gly Ala Glu Tyr Ile Leu Glu Thr Ile Asp Ser Leu Gln Lys His 
         275                280                285
Ser Trp Val Ala Asp Ile Gln Gly Cys Val Asp Pro Gly Asp Ser Glu 
     290                295                300
Glu Asp Thr Gly Leu Ser Cys Ala Arg Gly Gly Cys Leu Ala Ser Arg 
 305                310                315                320
Val Thr Ser Cys Ser Cys Glu Leu Leu Thr Glu Ala Asp Met Pro Arg 
                 325                330                335
Pro Pro Glu Thr Met Thr Ala Val Gly Ala Val Val Thr Ala Pro His 
             340                345                350
Gly Arg Ala Arg Asp Thr Val Gly Glu Ser Leu Ala His Val Pro Leu 
         355                360                365
Glu Thr Phe Leu Gln Thr Leu Glu Ser Ser Gly Gly Val Ser Glu Ser 
     370                375                380
Asn Asn Thr Gly Asp Glu Gly Ala Glu Leu Asp Pro Asp Ala Glu Ala 
 385                390                395                400
Glu Leu Glu Leu Ser Asp Tyr Pro Trp Phe His Gly Thr Leu Ser Arg 
                 405                410                415
Val Lys Ala Ala Gln Leu Val Leu Ala Gly Gly Pro Arg Ser His Gly 
             420                425                430
Leu Phe Val Ile Arg Gln Ser Glu Thr Arg Pro Gly Glu Cys Val Leu 
         435                440                445
Thr Phe Asn Phe Gln Gly Lys Ala Lys His Leu Arg Leu Ser Leu Asn 
     450                455                460
Gly His Gly Gln Cys His Val Gln His Leu Trp Phe Gln Ser Val Phe 
 465                470                475                480
Asp Met Leu Arg His Phe His Thr His Pro Ile Pro Leu Glu Ser Gly 
                 485                490                495
Gly Ser Ala Asp Ile Thr Leu Arg Ser Tyr Val Arg Ala Gln Gly Pro 
             500                505                510
Pro Pro Asp Pro Gly Pro Ala Pro Asn Thr Ala Ala Pro Val Pro Ala 
         515                520                525
Cys Trp Thr Glu Pro Ala Gly Gln His Tyr Phe Ser Ser Leu Ala Thr 
     530                535                540
Ala Thr Cys Pro Pro Thr Ser Pro Ser Asn Gly Ala Gly Ala Ser Ser 
 545                550                555                560
Ser Ser Gly Ser Ser Ser Ser Ala Thr Ser Val Pro Pro Arg Pro Ala 
                 565                570                575
Glu Gly Pro Leu Ser Ala Arg Ser Arg Ser Asn Ser Thr Glu His Leu 
             580                585                590
Leu Glu Ala Ala Ser Gly Ala Thr Glu Glu Pro Ala Asp Ala Thr Leu 
         595                600                605
Gly Arg Ala Arg Ala Val Glu Asn Gln Tyr Ser Phe Tyr 
     610                615                620



<210> 1258
<211> 2110
<212> DNA
<213> Homo sapiens
<308> AB000520
<400> 1258

ggatccaag  tattgtcct  cccatggct  cccatctca  gacgctctc  ggccgctat  60
atcccagca  tggagttca  cccactact  tgaaccagc  gcaggtggc  gctatggga  120
tgaagccat  aatggtgcc  gccctggcc  cgccgcagc  gccccggtc  cagtcccgg  180
cccggtccc  gactggcgg  agttctgcg  gctgcatgc  caggcggcc  ccgtggact  240
tgcgcacaa  ttctgccgt  tcctgcggg  caacccagc  tacgacacg  ccgacgccg  300
cgcctcctt  tcccgccac  tcgccgcca  cttcctgga  gtcttcggc  aggaggtgc  360
ccgcgtgct  gtggctggg  cgacgactc  gggcgcggc  gtgagcgca  aggccatgg  420
gccggagct  gcggacacc  ctgcactca  ggcggcgtc  tacggccac  cgcggagct  480
ggaggacgt  tccacgcac  cggccacca  ggcccgcgt  cgcaagggc  tctcgctgc  540
caacatgag  ctgtgcgtg  tggacggcg  gcgcgacat  tggcaccgg  gcgcctcgc  600
cgagcccga  gcggcagct  ccccgcgca  cgccgagcc  cgcgacaag  ggacgcggc  660
cctgaggct  tcgcggacg  tggctgcca  ggtggagct  gtggacatt  aacgcgagg  720
ggcgctgcg  ttcatggtg  ccgacgacg  ggccgcggg  tccgggggc  cggctcagt  780
gcagaagtg  cgcctgctc  tgcgcaggg  tgtggccga  gaacgcttc  gcctggagt  840
cttcgtgcc  cccaaagcc  ccaggccca  ggtcagcat  ccactgtca  ccatcattg  900
ggtccgcac  accatgccc  tggaaatgc  agagaagga  aacacattc  tcctcaagg  960
agagaatgg  gccgaatac  tcttggaga  catcgactc  ctgcagaag  actcgtggg  1020
agctgacat  cagggctgc  tggaccccg  tgacagtga  gaagacacc  agctctcct  1080
tacccgagg  ggctgtctg  ccagccgcg  ggcctcctg  agctgtgag  tcctgactg  1140
tgcagtcga  ctgccccgc  ccccagaga  gacagccgt  ggtgcagtg  tgacagccc  1200
ccacagccg  ggtcgagat  ccgtcagag  atccctgat  cacgtcccg  tagagacct  1260
tctgcagac  ctggaatcc  cgggcggca  cggcagtga  agcaataac  caggggaac  1320
gggtgcaga  acggatccc  aggctgaac  cgagctgga  ctatccgac  acccatggt  1380
ccacgggac  ctgtcccgg  tcaaggctg  tcaactggt  ctggcaggg  ggccccgga  1440
ccacggcct  ttcgtgatc  gccaaagtg  gactcggcc  ggggagtac  tgctgacct  1500
caacttcca  ggcaaggcc  agcacctgc  cctgtccct  aacggccac  gccagtgtc  1560
cgtacagca  ctgtggttc  agtctgtgc  tgacatgct  cgccacttc  acacacacc  1620
catcccact  gagtcaggg  gctcggccg  catcaccct  cgcagctat  tgcgggccc  1680
ggacccccc  ccagagccg  gccccacgc  ccctgccgc  cccgcgtcc  cggcctgct  1740
gagcgactc  cccggccag  actacttct  cagcctcgc  gcggccgcc  gcccgcctg  1800
ctcgccctc  gacgccgcc  gcgcctcct  gtcttccgc  tcgtcgtcc  ctgccgcgt  1860
ggggcccgc  cccccgcgc  ccgtcgagg  ccagctcag  gcgcggagc  gcagcaaca  1920
cgccgagcg  ctgctggag  ccgtggccg  caccgccgc  gaggagccc  cggaggccg  1980
gcccggccg  gcgcgcgcc  tggagaacc  gtactcctt  tactagccc  cggcgccgc  2040
cgggtggga  acgccaagc  cttcagtga  gacacgatg  tattaaaag  ctgttttag  2100
gactgcaaaa  2110



<210> 1259
<211> 632
<212> PRT
<213> Homo sapiens
<308> BAA22514
<400> 1259

Met Asn Gly Ala Gly Pro Gly Pro Ala Ala Ala Ala Pro Val Pro Val 
  1               5                  10                  15
Pro Val Pro Val Pro Asp Trp Arg Gln Phe Cys Glu Leu His Ala Gln 
             20                  25                  30
Ala Ala Ala Val Asp Phe Ala His Lys Phe Cys Arg Phe Leu Arg Asp 
         35                  40                  45
Asn Pro Ala Tyr Asp Thr Pro Asp Ala Gly Ala Ser Phe Ser Arg His 
     50                  55                  60
Phe Ala Ala Asn Phe Leu Asp Val Phe Gly Glu Glu Val Arg Arg Val 
 65                  70                  75                  80
Leu Val Ala Gly Pro Thr Thr Arg Gly Ala Ala Val Ser Ala Glu Ala 
                 85                  90                  95
Met Glu Pro Glu Leu Ala Asp Thr Ser Ala Leu Lys Ala Ala Ser Tyr 
             100                105                110
Gly His Ser Arg Ser Ser Glu Asp Val Ser Thr His Ala Ala Thr Lys 
         115                120                125
Ala Arg Val Arg Lys Gly Phe Ser Leu Arg Asn Met Ser Leu Cys Val 
     130                135                140
Val Asp Gly Val Arg Asp Met Trp His Arg Arg Ala Ser Pro Glu Pro 
 145                150                155                160
Asp Ala Ala Ala Ala Pro Arg Thr Ala Glu Pro Arg Asp Lys Trp Thr 
                 165                170                175
Arg Arg Leu Arg Leu Ser Arg Thr Leu Ala Ala Lys Val Glu Leu Val 
             180                185                190
Asp Ile Gln Arg Glu Gly Ala Leu Arg Phe Met Val Ala Asp Asp Ala 
         195                200                205
Ala Ala Gly Ser Gly Gly Ser Ala Gln Trp Gln Lys Cys Arg Leu Leu 
     210                215                220
Leu Arg Arg Ala Val Ala Glu Glu Arg Phe Arg Leu Glu Phe Phe Val 
 225                230                235                240
Pro Pro Lys Ala Ser Arg Pro Lys Val Ser Ile Pro Leu Ser Ala Ile 
                 245                250                255
Ile Glu Val Arg Thr Thr Met Pro Leu Glu Met Pro Glu Lys Asp Asn 
             260                265                270
Thr Phe Val Leu Lys Val Glu Asn Gly Ala Glu Tyr Ile Leu Glu Thr 
         275                280                285
Ile Asp Ser Leu Gln Lys His Ser Trp Val Ala Asp Ile Gln Gly Cys 
     290                295                300
Val Asp Pro Gly Asp Ser Glu Glu Asp Thr Glu Leu Ser Cys Thr Arg 
 305                310                315                320
Gly Gly Cys Leu Ala Ser Arg Val Ala Ser Cys Ser Cys Glu Leu Leu 
                 325                330                335
Thr Asp Ala Val Asp Leu Pro Arg Pro Pro Glu Thr Thr Ala Val Gly 
             340                345                350
Ala Val Val Thr Ala Pro His Ser Arg Gly Arg Asp Ala Val Arg Glu 
         355                360                365
Ser Leu Ile His Val Pro Leu Glu Thr Phe Leu Gln Thr Leu Glu Ser 
     370                375                380
Pro Gly Gly Ser Gly Ser Asp Ser Asn Asn Thr Gly Glu Gln Gly Ala 
 385                390                395                400
Glu Thr Asp Pro Glu Ala Glu Pro Glu Leu Glu Leu Ser Asp Tyr Pro 
                 405                410                415
Trp Phe His Gly Thr Leu Ser Arg Val Lys Ala Ala Gln Leu Val Leu 
             420                425                430
Ala Gly Gly Pro Arg Asn His Gly Leu Phe Val Ile Arg Gln Ser Glu 
         435                440                445
Thr Arg Pro Gly Glu Tyr Val Leu Thr Phe Asn Phe Gln Gly Lys Ala 
     450                455                460
Lys His Leu Arg Leu Ser Leu Asn Gly His Gly Gln Cys His Val Gln 
 465                470                475                480
His Leu Trp Phe Gln Ser Val Leu Asp Met Leu Arg His Phe His Thr 
                 485                490                495
His Pro Ile Pro Leu Glu Ser Gly Gly Ser Ala Asp Ile Thr Leu Arg 
             500                505                510
Ser Tyr Val Arg Ala Gln Asp Pro Pro Pro Glu Pro Gly Pro Thr Pro 
         515                520                525
Pro Ala Ala Pro Ala Ser Pro Ala Cys Trp Ser Asp Ser Pro Gly Gln 
     530                535                540
His Tyr Phe Ser Ser Leu Ala Ala Ala Ala Cys Pro Pro Ala Ser Pro 
 545                550                555                560
Ser Asp Ala Ala Gly Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala 
                 565                570                575
Ala Ser Gly Pro Ala Pro Pro Arg Pro Val Glu Gly Gln Leu Ser Ala 
             580                585                590
Arg Ser Arg Ser Asn Ser Ala Glu Arg Leu Leu Glu Ala Val Ala Ala 
         595                600                605
Thr Ala Ala Glu Glu Pro Pro Glu Ala Ala Pro Gly Arg Ala Arg Ala 
     610                615                620
Val Glu Asn Gln Tyr Ser Phe Tyr 
 625                630



<210> 1260
<211> 1330
<212> DNA
<213> Rattus norvegicus
<308> AF095741
<400> 1260

gggttagtt  aacatgggt  cctccagct  caccgctct  gctcgcctt  gactccccg  60
gcagccgcg  tccacctgg  tcggcgtcg  cgcgctggg  ctggccgca  tggcgctgg  120
gaccgtggc  tggcgtcgc  cgcgtcccc  gcggcgccg  cagctgcag  aagtgggca  180
ggtgtcgaa  gtttggatc  acccgatca  gtcctgcaa  ggggtgtcg  tgtgcgaga  240
tgagtgcac  gacatgggg  tgcgctgcg  caaagtgcg  gacaggttt  ggatggtgg  300
taaggaaga  ggtcacatg  tcactgccc  ccaggagcc  cgccttgtg  tggtcacca  360
caccttgga  aacaattac  tgatgctcg  agctccagg  atggagccg  tagttctgc  420
tatcaagct  ccctcttcg  ataagatcc  cgactgcag  ttgtttggc  tcgacatta  480
aggcaggga  tgtggcgat  aggtggccc  gtggttcac  agctaccta  agacgcaag  540
ctacaggtt  gttcagttt  ataccaaaa  gaaaggaag  acaacaaag  aactctacc  600
gtcggagag  taccttcag  actatgagg  cgcctaccc  gactgcagc  ctatccacc  660
gatttctga  gcctcctta  tggatctca  caccaggct  cagaagaaa  tgaagatgg  720
gtatttcag  ccgaacatc  tggtgtcag  ctgcgaggc  ttcgaggag  acacctggg  780
tgagctctt  attggtgac  tagagatga  gagggtgtt  agctgcccc  ggtgcgtgt  840
gactacagt  gacccagac  ccggcatca  agacaggaa  gagccgctg  agaccctga  900
gagctatcg  ctgtgtgat  cttctgtga  gagtttata  cagtcgtct  cactctttg  960
gatgtattt  tcagtggaa  aaattggaa  cctgagagt  ggtgaccct  tgtatcgga  1020
ggtggatta  tggatcccg  ggactgact  ggtttggat  attcacaac  gacagtctg  1080
gtaacagag  gatggggaa  cttgtcatt  actcggctt  cctgggaga  gacgcatct  1140
caagtcctc  cggccatct  cctggaaat  gatctctgt  cttcctctg  agctgcaca  1200
gcccgagtt  attcaagaa  gctaccaga  gtggtttgg  aatgtgacg  tgtataaat  1260
ttagataat  aggttttaa  aaattaaac  gaattgtta  tcccacggt  aaaaaaaaa  1320
aaaaaaaaaa  1330



<210> 1261
<211> 338
<212> PRT
<213> Rattus norvegicus
<308> AAC64190
<400> 1261

Met Gly Ser Ser Ser Ser Thr Ala Leu Ala Arg Leu Gly Leu Pro Gly 
  1               5                  10                  15
Gln Pro Arg Ser Thr Trp Leu Gly Val Ala Ala Leu Gly Leu Ala Ala 
             20                  25                  30
Val Ala Leu Gly Thr Val Ala Trp Arg Arg Ala Arg Pro Arg Arg Arg 
         35                  40                  45
Arg Gln Leu Gln Gln Val Gly Thr Val Ser Lys Val Trp Ile Tyr Pro 
     50                  55                  60
Ile Lys Ser Cys Lys Gly Val Ser Val Cys Glu Thr Glu Cys Thr Asp 
 65                  70                  75                  80
Met Gly Leu Arg Cys Gly Lys Val Arg Asp Arg Phe Trp Met Val Val 
                 85                  90                  95
Lys Glu Asp Gly His Met Ile Thr Ala Arg Gln Glu Pro Arg Leu Val 
             100                105                110
Leu Val Thr Ile Thr Leu Glu Asn Asn Tyr Leu Met Leu Glu Ala Pro 
         115                120                125
Gly Met Glu Pro Ile Val Leu Pro Ile Lys Leu Pro Ser Ser Asn Lys 
     130                135                140
Ile His Asp Cys Arg Leu Phe Gly Leu Asp Ile Lys Gly Arg Asp Cys 
 145                150                155                160
Gly Asp Glu Val Ala Arg Trp Phe Thr Ser Tyr Leu Lys Thr Gln Ala 
                 165                170                175
Tyr Arg Leu Val Gln Phe Asp Thr Lys Met Lys Gly Arg Thr Thr Lys 
             180                185                190
Lys Leu Tyr Pro Ser Glu Ser Tyr Leu Gln Asn Tyr Glu Val Ala Tyr 
         195                200                205
Pro Asp Cys Ser Pro Ile His Leu Ile Ser Glu Ala Ser Leu Val Asp 
     210                215                220
Leu Asn Thr Arg Leu Gln Lys Lys Val Lys Met Glu Tyr Phe Arg Pro 
 225                230                235                240
Asn Ile Val Val Ser Gly Cys Glu Ala Phe Glu Glu Asp Thr Trp Asp 
                 245                250                255
Glu Leu Leu Ile Gly Asp Val Glu Met Lys Arg Val Leu Ser Cys Pro 
             260                265                270
Arg Cys Val Leu Thr Thr Val Asp Pro Asp Thr Gly Ile Ile Asp Arg 
         275                280                285
Lys Glu Pro Leu Glu Thr Leu Lys Ser Tyr Arg Leu Cys Asp Pro Ser 
     290                295                300
Val Lys Ser Leu Tyr Gln Ser Ser Pro Leu Phe Gly Met Tyr Phe Ser 
 305                310                315                320
Val Glu Lys Ile Gly Ser Leu Arg Val Gly Asp Pro Val Tyr Arg Met 
                 325                330                335
Val Asp 
             340



<210> 1262
<211> 853
<212> DNA
<213> Homo sapiens
<308> AK000612
<400> 1262

aaaacttct  cccactctt  atcagaatt  ccaggtggc  tacccagac  actgcccgc  60
cctgatcat  acagatgcc  ccctggtag  tttgaatac  aggatggag  agaaaatga  120
aatggagaa  ttcaggcca  atattgtgg  gaccggctg  gatgctttt  aggaggata  180
ctgggatga  ctcctaatt  gtagtgtag  agtgaaaaa  gtaatggca  gccccaggt  240
tattttgac  acggtggac  cagacactg  agtcataga  aggaaacag  cactggaca  300
cctgaagag  taccgcctg  gtgatcctt  tgagaggga  ttgtacaag  tgtctccac  360
ttttgggat  tattattca  tggaaaaaa  tggaagcct  agagttggt  accctgtgt  420
tcggatggt  tagtgatga  tgatggatc  actagggtg  tatggcttc  gcaaccagg  480
gggattgac  gagatctta  caacagcag  aacgataca  cagcaaatc  ttattatcc  540
gccttcaac  atctttacc  tggaaaaca  tctcgattt  tgacttttc  aagttgtgt  600
tgctccagg  taatgcaag  aaagtatta  aggggggaa  atgaaagta  atatataaa  660
tttaggtac  gaaggcttt  aaaataatt  agatcatca  aaatgctat  ttgaatgtt  720
tcatggcta  tacactttt  cttcctgac  ttaatattg  tgaataaag  aagtttaat  780
aatcaacta  aaaaaaaaa  aaaaaaaaa  acaaacaaa  aaaaaaaaa  aaaaaaaaa  840
aaaaaaaaa  aaa  853



<210> 1263
<211> 122
<212> PRT
<213> Homo sapiens
<308> AK000612
<400> 1263

Met Thr Asp Ala Ser Leu Val Asp Leu Asn Thr Arg Met Glu Lys Lys 
  1               5                  10                  15
Met Lys Met Glu Asn Phe Arg Pro Asn Ile Val Val Thr Gly Cys Asp 
             20                  25                  30
Ala Phe Glu Glu Asp Thr Trp Asp Glu Leu Leu Ile Gly Ser Val Glu 
         35                  40                  45
Val Lys Lys Val Met Ala Cys Pro Arg Cys Ile Leu Thr Thr Val Asp 
     50                  55                  60
Pro Asp Thr Gly Val Ile Asp Arg Lys Gln Pro Leu Asp Thr Leu Lys 
 65                  70                  75                  80
Ser Tyr Arg Leu Cys Asp Pro Ser Glu Arg Glu Leu Tyr Lys Leu Ser 
                 85                  90                  95
Pro Leu Phe Gly Ile Tyr Tyr Ser Val Glu Lys Ile Gly Ser Leu Arg 
             100                105                110
Val Gly Asp Pro Val Tyr Arg Met Val Ter 
         115                120



<210> 1264
<211> 1330
<212> DNA
<213> Rattus norvegicus
<308> AF095741
<400> 1264

gggttagtt  aacatgggt  cctccagct  caccgctct  gctcgcctt  gactccccg  60
gcagccgcg  tccacctgg  tcggcgtcg  cgcgctggg  ctggccgca  tggcgctgg  120
gaccgtggc  tggcgtcgc  cgcgtcccc  gcggcgccg  cagctgcag  aagtgggca  180
ggtgtcgaa  gtttggatc  acccgatca  gtcctgcaa  ggggtgtcg  tgtgcgaga  240
tgagtgcac  gacatgggg  tgcgctgcg  caaagtgcg  gacaggttt  ggatggtgg  300
taaggaaga  ggtcacatg  tcactgccc  ccaggagcc  cgccttgtg  tggtcacca  360
caccttgga  aacaattac  tgatgctcg  agctccagg  atggagccg  tagttctgc  420
tatcaagct  ccctcttcg  ataagatcc  cgactgcag  ttgtttggc  tcgacatta  480
aggcaggga  tgtggcgat  aggtggccc  gtggttcac  agctaccta  agacgcaag  540
ctacaggtt  gttcagttt  ataccaaaa  gaaaggaag  acaacaaag  aactctacc  600
gtcggagag  taccttcag  actatgagg  cgcctaccc  gactgcagc  ctatccacc  660
gatttctga  gcctcctta  tggatctca  caccaggct  cagaagaaa  tgaagatgg  720
gtatttcag  ccgaacatc  tggtgtcag  ctgcgaggc  ttcgaggag  acacctggg  780
tgagctctt  attggtgac  tagagatga  gagggtgtt  agctgcccc  ggtgcgtgt  840
gactacagt  gacccagac  ccggcatca  agacaggaa  gagccgctg  agaccctga  900
gagctatcg  ctgtgtgat  cttctgtga  gagtttata  cagtcgtct  cactctttg  960
gatgtattt  tcagtggaa  aaattggaa  cctgagagt  ggtgaccct  tgtatcgga  1020
ggtggatta  tggatcccg  ggactgact  ggtttggat  attcacaac  gacagtctg  1080
gtaacagag  gatggggaa  cttgtcatt  actcggctt  cctgggaga  gacgcatct  1140
caagtcctc  cggccatct  cctggaaat  gatctctgt  cttcctctg  agctgcaca  1200
gcccgagtt  attcaagaa  gctaccaga  gtggtttgg  aatgtgacg  tgtataaat  1260
ttagataat  aggttttaa  aaattaaac  gaattgtta  tcccacggt  aaaaaaaaa  1320
aaaaaaaaaa  1330



<210> 1265
<211> 338
<212> PRT
<213> Rattus norvegicus
<308> AAC64190
<400> 1265

Met Gly Ser Ser Ser Ser Thr Ala Leu Ala Arg Leu Gly Leu Pro Gly 
  1               5                  10                  15
Gln Pro Arg Ser Thr Trp Leu Gly Val Ala Ala Leu Gly Leu Ala Ala 
             20                  25                  30
Val Ala Leu Gly Thr Val Ala Trp Arg Arg Ala Arg Pro Arg Arg Arg 
         35                  40                  45
Arg Gln Leu Gln Gln Val Gly Thr Val Ser Lys Val Trp Ile Tyr Pro 
     50                  55                  60
Ile Lys Ser Cys Lys Gly Val Ser Val Cys Glu Thr Glu Cys Thr Asp 
 65                  70                  75                  80
Met Gly Leu Arg Cys Gly Lys Val Arg Asp Arg Phe Trp Met Val Val 
                 85                  90                  95
Lys Glu Asp Gly His Met Ile Thr Ala Arg Gln Glu Pro Arg Leu Val 
             100                105                110
Leu Val Thr Ile Thr Leu Glu Asn Asn Tyr Leu Met Leu Glu Ala Pro 
         115                120                125
Gly Met Glu Pro Ile Val Leu Pro Ile Lys Leu Pro Ser Ser Asn Lys 
     130                135                140
Ile His Asp Cys Arg Leu Phe Gly Leu Asp Ile Lys Gly Arg Asp Cys 
 145                150                155                160
Gly Asp Glu Val Ala Arg Trp Phe Thr Ser Tyr Leu Lys Thr Gln Ala 
                 165                170                175
Tyr Arg Leu Val Gln Phe Asp Thr Lys Met Lys Gly Arg Thr Thr Lys 
             180                185                190
Lys Leu Tyr Pro Ser Glu Ser Tyr Leu Gln Asn Tyr Glu Val Ala Tyr 
         195                200                205
Pro Asp Cys Ser Pro Ile His Leu Ile Ser Glu Ala Ser Leu Val Asp 
     210                215                220
Leu Asn Thr Arg Leu Gln Lys Lys Val Lys Met Glu Tyr Phe Arg Pro 
 225                230                235                240
Asn Ile Val Val Ser Gly Cys Glu Ala Phe Glu Glu Asp Thr Trp Asp 
                 245                250                255
Glu Leu Leu Ile Gly Asp Val Glu Met Lys Arg Val Leu Ser Cys Pro 
             260                265                270
Arg Cys Val Leu Thr Thr Val Asp Pro Asp Thr Gly Ile Ile Asp Arg 
         275                280                285
Lys Glu Pro Leu Glu Thr Leu Lys Ser Tyr Arg Leu Cys Asp Pro Ser 
     290                295                300
Val Lys Ser Leu Tyr Gln Ser Ser Pro Leu Phe Gly Met Tyr Phe Ser 
 305                310                315                320
Val Glu Lys Ile Gly Ser Leu Arg Val Gly Asp Pro Val Tyr Arg Met 
                 325                330                335
Val Asp 
             340



<210> 1266
<211> 853
<212> DNA
<213> Homo sapiens
<308> AK000612
<400> 1266

aaaacttct  cccactctt  atcagaatt  ccaggtggc  tacccagac  actgcccgc  60
cctgatcat  acagatgcc  ccctggtag  tttgaatac  aggatggag  agaaaatga  120
aatggagaa  ttcaggcca  atattgtgg  gaccggctg  gatgctttt  aggaggata  180
ctgggatga  ctcctaatt  gtagtgtag  agtgaaaaa  gtaatggca  gccccaggt  240
tattttgac  acggtggac  cagacactg  agtcataga  aggaaacag  cactggaca  300
cctgaagag  taccgcctg  gtgatcctt  tgagaggga  ttgtacaag  tgtctccac  360
ttttgggat  tattattca  tggaaaaaa  tggaagcct  agagttggt  accctgtgt  420
tcggatggt  tagtgatga  tgatggatc  actagggtg  tatggcttc  gcaaccagg  480
gggattgac  gagatctta  caacagcag  aacgataca  cagcaaatc  ttattatcc  540
gccttcaac  atctttacc  tggaaaaca  tctcgattt  tgacttttc  aagttgtgt  600
tgctccagg  taatgcaag  aaagtatta  aggggggaa  atgaaagta  atatataaa  660
tttaggtac  gaaggcttt  aaaataatt  agatcatca  aaatgctat  ttgaatgtt  720
tcatggcta  tacactttt  cttcctgac  ttaatattg  tgaataaag  aagtttaat  780
aatcaacta  aaaaaaaaa  aaaaaaaaa  acaaacaaa  aaaaaaaaa  aaaaaaaaa  840
aaaaaaaaa  aaa  853



<210> 1267
<211> 122
<212> PRT
<213> Homo sapiens
<308> AK000612
<400> 1267

Met Thr Asp Ala Ser Leu Val Asp Leu Asn Thr Arg Met Glu Lys Lys 
  1               5                  10                  15
Met Lys Met Glu Asn Phe Arg Pro Asn Ile Val Val Thr Gly Cys Asp 
             20                  25                  30
Ala Phe Glu Glu Asp Thr Trp Asp Glu Leu Leu Ile Gly Ser Val Glu 
         35                  40                  45
Val Lys Lys Val Met Ala Cys Pro Arg Cys Ile Leu Thr Thr Val Asp 
     50                  55                  60
Pro Asp Thr Gly Val Ile Asp Arg Lys Gln Pro Leu Asp Thr Leu Lys 
 65                  70                  75                  80
Ser Tyr Arg Leu Cys Asp Pro Ser Glu Arg Glu Leu Tyr Lys Leu Ser 
                 85                  90                  95
Pro Leu Phe Gly Ile Tyr Tyr Ser Val Glu Lys Ile Gly Ser Leu Arg 
             100                105                110
Val Gly Asp Pro Val Tyr Arg Met Val Ter 
         115                120



<210> 1268
<211> 1318
<212> DNA
<213> Rattus norvegicus
<308> AF095927
<400> 1268

cgccgccca  gctagcgcg  gcctccgct  catcgcccc  ccgccatgg  cctattcgg  60
gacttgccg  agcccgagc  cccgccgcg  ccgtctgcc  ggaaagaag  acaggaagg  120
cccgtgctc  tcgaggacc  gcccccgac  agcagtact  actcaggat  tgggggacc  180
ttactcttt  atggtcttc  acctgctgg  agcggcaat  caggttctc  tgccacatc  240
ggctcccag  tggtgaaga  cgaaggaaa  ggagcaaag  ggaaagccc  tgaggaaga  300
aagaatggc  gtgaagagc  tgtggaaaa  aaagtttgt  aagcctctt  ggtgatctt  360
ggtttgaaa  gctacgtgg  agagcggaa  ggtgagagg  aggagatgc  ggacgccca  420
gtcatcctg  atgatatca  tcaggagtg  aatcctcca  catctctca  tactcgggt  480
tcatacttt  ctgtttttg  tggacatgg  ggaattcga  cctcgaaat  tgctgcaca  540
aatttgcac  agaacttaa  caggaaatt  cctaaagga  atgtaatca  tgtggagaa  600
actgtgaag  ggtgcctgc  agatacttt  aagcacacc  atgaagagt  cctgaaaca  660
gcttcaagc  agaagcctg  ctggaaaga  gggtccact  ccacgtgtg  cctggctgt  720
gacaacatc  tgtatatcg  caaccttgg  gatagtcgg  caatcctgt  tcgatataa  780
gaggaaagt  aaaagcatg  agccttaag  ctcagcaaa  agcacaatc  aactcagta  840
gaagagcgc  tgaggatac  gaaggctgg  ggcaatgtc  gagatggcc  tgtcttggg  900
gtgctggag  tatcccgct  cattggaga  gggcagtac  agcgttgcg  ggtcacatc  960
gtgcctgat  tcagacgct  ccagttgac  cccaatgac  ggttcattt  gctggcttg  1020
gatgggctc  tcaaggtct  taccccaga  gaagctgtg  acttcatct  gtcctgcct  1080
gaggatgag  agatccaga  ccgagaagg  aagcctgct  ttgatgccc  ctatgaagc  1140
gcatgcaac  ggctggcta  caaggcagt  cagcggggc  cggcagata  cgtgacggt  1200
atggtggtg  ggataggac  ctgaggccg  acactgcac  tgtgctctt  acttgcagg  1260
tcatcttgt  tgtgcacgc  gtgtgtact  ctgtggggc  tctatggtt  taaataaa  1318



<210> 1269
<211> 392
<212> PRT
<213> Rattus norvegicus
<308> AAC97497
<400> 1269

Met Asp Leu Phe Gly Asp Leu Pro Glu Pro Glu Arg Pro Pro Arg Pro 
  1               5                  10                  15
Ser Ala Gly Lys Glu Ala Gln Glu Gly Pro Val Leu Phe Glu Asp Leu 
             20                  25                  30
Pro Pro Thr Ser Ser Thr Asp Ser Gly Ser Gly Gly Pro Leu Leu Phe 
         35                  40                  45
Asp Gly Leu Pro Pro Ala Gly Ser Gly Asn Ser Gly Ser Leu Ala Thr 
     50                  55                  60
Ser Gly Ser Gln Val Val Lys Asn Glu Gly Lys Gly Ala Lys Arg Lys 
 65                  70                  75                  80
Ala Pro Glu Glu Glu Lys Asn Gly Gly Glu Glu Leu Val Glu Lys Lys 
                 85                  90                  95
Val Cys Lys Ala Ser Ser Val Ile Phe Gly Leu Lys Gly Tyr Val Ala 
             100                105                110
Glu Arg Lys Gly Glu Arg Glu Glu Met Gln Asp Ala His Val Ile Leu 
         115                120                125
Asn Asp Ile Thr Gln Glu Cys Asn Pro Pro Ser Ser Leu Ile Thr Arg 
     130                135                140
Val Ser Tyr Phe Ala Val Phe Asp Gly His Gly Gly Ile Arg Ala Ser 
 145                150                155                160
Lys Phe Ala Ala Gln Asn Leu His Gln Asn Leu Ile Arg Lys Phe Pro 
                 165                170                175
Lys Gly Asp Val Ile Ser Val Glu Lys Thr Val Lys Arg Cys Leu Leu 
             180                185                190
Asp Thr Phe Lys His Thr Asp Glu Glu Phe Leu Lys Gln Ala Ser Ser 
         195                200                205
Gln Lys Pro Ala Trp Lys Asp Gly Ser Thr Ala Thr Cys Val Leu Ala 
     210                215                220
Val Asp Asn Ile Leu Tyr Ile Ala Asn Leu Gly Asp Ser Arg Ala Ile 
 225                230                235                240
Leu Cys Arg Tyr Asn Glu Glu Ser Gln Lys His Ala Ala Leu Ser Leu 
                 245                250                255
Ser Lys Glu His Asn Pro Thr Gln Tyr Glu Glu Arg Met Arg Ile Gln 
             260                265                270
Lys Ala Gly Gly Asn Val Arg Asp Gly Arg Val Leu Gly Val Leu Glu 
         275                280                285
Val Ser Arg Ser Ile Gly Asp Gly Gln Tyr Lys Arg Cys Gly Val Thr 
     290                295                300
Ser Val Pro Asp Ile Arg Arg Cys Gln Leu Thr Pro Asn Asp Arg Phe 
 305                310                315                320
Ile Leu Leu Ala Cys Asp Gly Leu Phe Lys Val Phe Thr Pro Glu Glu 
                 325                330                335
Ala Val Asn Phe Ile Leu Ser Cys Leu Glu Asp Glu Lys Ile Gln Thr 
             340                345                350
Arg Glu Gly Lys Pro Ala Val Asp Ala Arg Tyr Glu Ala Ala Cys Asn 
         355                360                365
Arg Leu Ala Asn Lys Ala Val Gln Arg Gly Ser Ala Asp Asn Val Thr 
     370                375                380
Val Met Val Val Arg Ile Gly His 
 385                390



<210> 1270
<211> 2654
<212> DNA
<213> Homo sapiens
<308> AK055417
<400> 1270

cttgtctca  agtcctggg  tcaagccat  ttcccacct  ggtctccca  agtgccagg  60
ttactcgca  gagccacca  acccagcct  ggatttgca  taaaaccag  aaagggacc  120
ctggagccc  agaaggcag  tccattgag  gtaaattta  ttgggaaca  tacatcatg  180
cttgcaaat  acaggcagt  agaacagct  tgagttata  accagacga  gtttttttt  240
tcatggctc  ggatgtcct  aattgaaaa  gaattccaa  aaacttgaa  gaaaagcag  300
tctctagaa  aaatgtcat  tctcgtggg  atttttgtt  ttttttttt  cttgaaata  360
tttatttga  gtcttttat  ccatatatg  gggttttct  gcaaaattt  aaaggggaa  420
gggaataag  gtagtaaga  aggttttaa  aatgagata  ttagaattt  tttgagtaa  480
aattctgta  tatcctccc  gctcttatg  agtcatgtg  tgaataaca  catcaagtc  540
gtgatggac  gcatatatg  cggtgctcc  ataagatta  aaattttgt  gagatgggg  600
tctcgctat  ttgcccagg  tggtcttga  ctcctggcc  caagtgatc  tcctgcctt  660
gccacctcc  gaagtgttg  gattaacag  cgtgagctg  cgtgttcag  cataatacc  720
tgtttactg  accttttct  tgtttaggt  tgtttaaat  cacaaatac  accagtgtg  780
tacaactgc  tatggtatt  agtgcagta  catgctgtg  agtttagcc  aggagcaat  840
ggctctacc  tgtatgtag  ttaggtgtg  agtaagctg  gccgcgtta  tttctgtaa  900
tatgttcta  gatgttcac  caacaaagt  acctaacaa  gcatttctg  taagtgatg  960
atgactgta  tttttactg  tttcgataa  taacttgat  tgtttgtta  tgtttaaaa  1020
caaatccga  ttaaatagg  acggagttc  gaattttag  tttgttgtc  gtgaaaaat  1080
agaattaac  gatcttgat  tttgaagca  atgtgagtt  taaacattt  atgtaaaat  1140
ctgggaaaa  tgttacatc  cttttagaa  attagacct  tagcaggtc  tgcagtctt  1200
accagaaac  ctcccacac  tacacacac  cagtgtttt  gtttttttt  tttttttta  1260
acagaatct  gctctgtca  cccggctga  gtgcagtgg  gcgatctca  ttcactgca  1320
gctccgcct  ctgggttca  gccattctc  tgcctcagc  tcccgagta  ctgggactg  1380
aggtgcctg  caccgcgcc  ggctaattt  tttgtattg  tagtagaga  ggggtttca  1440
cgtgttagc  aggatggtc  tgatctcct  atctcgtga  ccgcctgcc  cggcctccc  1500
aagcgctgg  attacaggc  tgagccccc  cacctggcc  acacacaag  atttttttt  1560
taaaaaaag  taaaatgct  tgaaagtta  ttaaatatt  gtctcagtt  aagcctttt  1620
tttcccatt  gtaacagtg  gactggtgt  ttaaccagt  tgacttcct  tgacttatt  1680
atgttcact  tttgagacg  aatttaaaa  ctttaatgg  aaagtgtgg  ttttgctgt  1740
agaatttga  taactctca  ttcgttctt  cagtactcg  gtttcatat  ttgctgttt  1800
tgatggaca  ggaggaatt  gagcctcaa  atttgctgc  cagaatttg  atcaaaact  1860
aatcagaaa  tttcctaaa  gagatgtaa  cagtgtaga  aaaaccgtg  agagatgcc  1920
tttggacac  ttcaagcat  ctgatgaag  gttccttaa  caagcttcc  gccagaagc  1980
tgcctggaa  gatgggtcc  ctgccacgt  tgttctggc  gtagacaac  ttctttata  2040
tgccaacct  ggagatagt  gggcaatct  gtgtcgtta  aatgaggag  gtcaaaaac  2100
tgcagcctt  agcctcagc  aagagcata  tccaactca  tatgaagag  ggatgagga  2160
acagaaggc  ggaggaaac  tcagggatg  gcgtgtttt  ggcgtgcta  aggtgtcac  2220
ctccattgg  gacgggcag  acaagcgct  cggtgtcac  tctgtgccc  acatcagac  2280
ctgccagct  acccccaat  acaggttca  tttgttggc  tgtgatggg  tcttcaagg  2340
ctttacccc  gaagaagcc  tgaacttca  cttgtcctg  ctcgaggat  aaaagatcc  2400
gacccggga  gggaagtcc  cagccgacg  ccgctacga  gcagcctgc  acaggctgg  2460
caacaaggc  gtgcagcgg  gctcggccg  caacgtcac  gtgatggtg  tgcggatag  2520
gcactgagg  gtggcgcgc  gccaggagc  cgcatggta  tgacttaaa  ggttcattt  2580
gtgtgtgtg  acattgtgt  ttttgtgta  tcctgtggg  ctcccatgg  tgtaaataa  2640
ggtttctct  tttt  2654



<210> 1271
<211> 392
<212> PRT
<213> Homo sapiens
<308> NP_110395
<400> 1271

Met Asp Leu Phe Gly Asp Leu Pro Glu Pro Glu Arg Ser Pro Arg Pro 
  1               5                  10                  15
Ala Ala Gly Lys Glu Ala Gln Lys Gly Pro Leu Leu Phe Asp Asp Leu 
             20                  25                  30
Pro Pro Ala Ser Ser Thr Asp Ser Gly Ser Gly Gly Pro Leu Leu Phe 
         35                  40                  45
Asp Asp Leu Pro Pro Ala Ser Ser Gly Asp Ser Gly Ser Leu Ala Thr 
     50                  55                  60
Ser Ile Ser Gln Met Val Lys Thr Glu Gly Lys Gly Ala Lys Arg Lys 
 65                  70                  75                  80
Thr Ser Glu Glu Glu Lys Asn Gly Ser Glu Glu Leu Val Glu Lys Lys 
                 85                  90                  95
Val Cys Lys Ala Ser Ser Val Ile Phe Gly Leu Lys Gly Tyr Val Ala 
             100                105                110
Glu Arg Lys Gly Glu Arg Glu Glu Met Gln Asp Ala His Val Ile Leu 
         115                120                125
Asn Asp Ile Thr Glu Glu Cys Arg Pro Pro Ser Ser Leu Ile Thr Arg 
     130                135                140
Val Ser Tyr Phe Ala Val Phe Asp Gly His Gly Gly Ile Arg Ala Ser 
 145                150                155                160
Lys Phe Ala Ala Gln Asn Leu His Gln Asn Leu Ile Arg Lys Phe Pro 
                 165                170                175
Lys Gly Asp Val Ile Ser Val Glu Lys Thr Val Lys Arg Cys Leu Leu 
             180                185                190
Asp Thr Phe Lys His Thr Asp Glu Glu Phe Leu Lys Gln Ala Ser Ser 
         195                200                205
Gln Lys Pro Ala Trp Lys Asp Gly Ser Thr Ala Thr Cys Val Leu Ala 
     210                215                220
Val Asp Asn Ile Leu Tyr Ile Ala Asn Leu Gly Asp Ser Arg Ala Ile 
 225                230                235                240
Leu Cys Arg Tyr Asn Glu Glu Ser Gln Lys His Ala Ala Leu Ser Leu 
                 245                250                255
Ser Lys Glu His Asn Pro Thr Gln Tyr Glu Glu Arg Met Arg Ile Gln 
             260                265                270
Lys Ala Gly Gly Asn Val Arg Asp Gly Arg Val Leu Gly Val Leu Glu 
         275                280                285
Val Ser Arg Ser Ile Gly Asp Gly Gln Tyr Lys Arg Cys Gly Val Thr 
     290                295                300
Ser Val Pro Asp Ile Arg Arg Cys Gln Leu Thr Pro Asn Asp Arg Phe 
 305                310                315                320
Ile Leu Leu Ala Cys Asp Gly Leu Phe Lys Val Phe Thr Pro Glu Glu 
                 325                330                335
Ala Val Asn Phe Ile Leu Ser Cys Leu Glu Asp Glu Lys Ile Gln Thr 
             340                345                350
Arg Glu Gly Lys Ser Ala Ala Asp Ala Arg Tyr Glu Ala Ala Cys Asn 
         355                360                365
Arg Leu Ala Asn Lys Ala Val Gln Arg Gly Ser Ala Asp Asn Val Thr 
     370                375                380
Val Met Val Val Arg Ile Gly His 
 385                390



<210> 1272
<211> 1318
<212> DNA
<213> Rattus norvegicus
<308> AF095927
<400> 1272

cgccgccca  gctagcgcg  gcctccgct  catcgcccc  ccgccatgg  cctattcgg  60
gacttgccg  agcccgagc  cccgccgcg  ccgtctgcc  ggaaagaag  acaggaagg  120
cccgtgctc  tcgaggacc  gcccccgac  agcagtact  actcaggat  tgggggacc  180
ttactcttt  atggtcttc  acctgctgg  agcggcaat  caggttctc  tgccacatc  240
ggctcccag  tggtgaaga  cgaaggaaa  ggagcaaag  ggaaagccc  tgaggaaga  300
aagaatggc  gtgaagagc  tgtggaaaa  aaagtttgt  aagcctctt  ggtgatctt  360
ggtttgaaa  gctacgtgg  agagcggaa  ggtgagagg  aggagatgc  ggacgccca  420
gtcatcctg  atgatatca  tcaggagtg  aatcctcca  catctctca  tactcgggt  480
tcatacttt  ctgtttttg  tggacatgg  ggaattcga  cctcgaaat  tgctgcaca  540
aatttgcac  agaacttaa  caggaaatt  cctaaagga  atgtaatca  tgtggagaa  600
actgtgaag  ggtgcctgc  agatacttt  aagcacacc  atgaagagt  cctgaaaca  660
gcttcaagc  agaagcctg  ctggaaaga  gggtccact  ccacgtgtg  cctggctgt  720
gacaacatc  tgtatatcg  caaccttgg  gatagtcgg  caatcctgt  tcgatataa  780
gaggaaagt  aaaagcatg  agccttaag  ctcagcaaa  agcacaatc  aactcagta  840
gaagagcgc  tgaggatac  gaaggctgg  ggcaatgtc  gagatggcc  tgtcttggg  900
gtgctggag  tatcccgct  cattggaga  gggcagtac  agcgttgcg  ggtcacatc  960
gtgcctgat  tcagacgct  ccagttgac  cccaatgac  ggttcattt  gctggcttg  1020
gatgggctc  tcaaggtct  taccccaga  gaagctgtg  acttcatct  gtcctgcct  1080
gaggatgag  agatccaga  ccgagaagg  aagcctgct  ttgatgccc  ctatgaagc  1140
gcatgcaac  ggctggcta  caaggcagt  cagcggggc  cggcagata  cgtgacggt  1200
atggtggtg  ggataggac  ctgaggccg  acactgcac  tgtgctctt  acttgcagg  1260
tcatcttgt  tgtgcacgc  gtgtgtact  ctgtggggc  tctatggtt  taaataaa  1318



<210> 1273
<211> 392
<212> PRT
<213> Rattus norvegicus
<308> AAC97497
<400> 1273

Met Asp Leu Phe Gly Asp Leu Pro Glu Pro Glu Arg Pro Pro Arg Pro 
  1               5                  10                  15
Ser Ala Gly Lys Glu Ala Gln Glu Gly Pro Val Leu Phe Glu Asp Leu 
             20                  25                  30
Pro Pro Thr Ser Ser Thr Asp Ser Gly Ser Gly Gly Pro Leu Leu Phe 
         35                  40                  45
Asp Gly Leu Pro Pro Ala Gly Ser Gly Asn Ser Gly Ser Leu Ala Thr 
     50                  55                  60
Ser Gly Ser Gln Val Val Lys Asn Glu Gly Lys Gly Ala Lys Arg Lys 
 65                  70                  75                  80
Ala Pro Glu Glu Glu Lys Asn Gly Gly Glu Glu Leu Val Glu Lys Lys 
                 85                  90                  95
Val Cys Lys Ala Ser Ser Val Ile Phe Gly Leu Lys Gly Tyr Val Ala 
             100                105                110
Glu Arg Lys Gly Glu Arg Glu Glu Met Gln Asp Ala His Val Ile Leu 
         115                120                125
Asn Asp Ile Thr Gln Glu Cys Asn Pro Pro Ser Ser Leu Ile Thr Arg 
     130                135                140
Val Ser Tyr Phe Ala Val Phe Asp Gly His Gly Gly Ile Arg Ala Ser 
 145                150                155                160
Lys Phe Ala Ala Gln Asn Leu His Gln Asn Leu Ile Arg Lys Phe Pro 
                 165                170                175
Lys Gly Asp Val Ile Ser Val Glu Lys Thr Val Lys Arg Cys Leu Leu 
             180                185                190
Asp Thr Phe Lys His Thr Asp Glu Glu Phe Leu Lys Gln Ala Ser Ser 
         195                200                205
Gln Lys Pro Ala Trp Lys Asp Gly Ser Thr Ala Thr Cys Val Leu Ala 
     210                215                220
Val Asp Asn Ile Leu Tyr Ile Ala Asn Leu Gly Asp Ser Arg Ala Ile 
 225                230                235                240
Leu Cys Arg Tyr Asn Glu Glu Ser Gln Lys His Ala Ala Leu Ser Leu 
                 245                250                255
Ser Lys Glu His Asn Pro Thr Gln Tyr Glu Glu Arg Met Arg Ile Gln 
             260                265                270
Lys Ala Gly Gly Asn Val Arg Asp Gly Arg Val Leu Gly Val Leu Glu 
         275                280                285
Val Ser Arg Ser Ile Gly Asp Gly Gln Tyr Lys Arg Cys Gly Val Thr 
     290                295                300
Ser Val Pro Asp Ile Arg Arg Cys Gln Leu Thr Pro Asn Asp Arg Phe 
 305                310                315                320
Ile Leu Leu Ala Cys Asp Gly Leu Phe Lys Val Phe Thr Pro Glu Glu 
                 325                330                335
Ala Val Asn Phe Ile Leu Ser Cys Leu Glu Asp Glu Lys Ile Gln Thr 
             340                345                350
Arg Glu Gly Lys Pro Ala Val Asp Ala Arg Tyr Glu Ala Ala Cys Asn 
         355                360                365
Arg Leu Ala Asn Lys Ala Val Gln Arg Gly Ser Ala Asp Asn Val Thr 
     370                375                380
Val Met Val Val Arg Ile Gly His 
 385                390



<210> 1274
<211> 2654
<212> DNA
<213> Homo sapiens
<308> AK055417
<400> 1274

cttgtctca  agtcctggg  tcaagccat  ttcccacct  ggtctccca  agtgccagg  60
ttactcgca  gagccacca  acccagcct  ggatttgca  taaaaccag  aaagggacc  120
ctggagccc  agaaggcag  tccattgag  gtaaattta  ttgggaaca  tacatcatg  180
cttgcaaat  acaggcagt  agaacagct  tgagttata  accagacga  gtttttttt  240
tcatggctc  ggatgtcct  aattgaaaa  gaattccaa  aaacttgaa  gaaaagcag  300
tctctagaa  aaatgtcat  tctcgtggg  atttttgtt  ttttttttt  cttgaaata  360
tttatttga  gtcttttat  ccatatatg  gggttttct  gcaaaattt  aaaggggaa  420
gggaataag  gtagtaaga  aggttttaa  aatgagata  ttagaattt  tttgagtaa  480
aattctgta  tatcctccc  gctcttatg  agtcatgtg  tgaataaca  catcaagtc  540
gtgatggac  gcatatatg  cggtgctcc  ataagatta  aaattttgt  gagatgggg  600
tctcgctat  ttgcccagg  tggtcttga  ctcctggcc  caagtgatc  tcctgcctt  660
gccacctcc  gaagtgttg  gattaacag  cgtgagctg  cgtgttcag  cataatacc  720
tgtttactg  accttttct  tgtttaggt  tgtttaaat  cacaaatac  accagtgtg  780
tacaactgc  tatggtatt  agtgcagta  catgctgtg  agtttagcc  aggagcaat  840
ggctctacc  tgtatgtag  ttaggtgtg  agtaagctg  gccgcgtta  tttctgtaa  900
tatgttcta  gatgttcac  caacaaagt  acctaacaa  gcatttctg  taagtgatg  960
atgactgta  tttttactg  tttcgataa  taacttgat  tgtttgtta  tgtttaaaa  1020
caaatccga  ttaaatagg  acggagttc  gaattttag  tttgttgtc  gtgaaaaat  1080
agaattaac  gatcttgat  tttgaagca  atgtgagtt  taaacattt  atgtaaaat  1140
ctgggaaaa  tgttacatc  cttttagaa  attagacct  tagcaggtc  tgcagtctt  1200
accagaaac  ctcccacac  tacacacac  cagtgtttt  gtttttttt  tttttttta  1260
acagaatct  gctctgtca  cccggctga  gtgcagtgg  gcgatctca  ttcactgca  1320
gctccgcct  ctgggttca  gccattctc  tgcctcagc  tcccgagta  ctgggactg  1380
aggtgcctg  caccgcgcc  ggctaattt  tttgtattg  tagtagaga  ggggtttca  1440
cgtgttagc  aggatggtc  tgatctcct  atctcgtga  ccgcctgcc  cggcctccc  1500
aagcgctgg  attacaggc  tgagccccc  cacctggcc  acacacaag  atttttttt  1560
taaaaaaag  taaaatgct  tgaaagtta  ttaaatatt  gtctcagtt  aagcctttt  1620
tttcccatt  gtaacagtg  gactggtgt  ttaaccagt  tgacttcct  tgacttatt  1680
atgttcact  tttgagacg  aatttaaaa  ctttaatgg  aaagtgtgg  ttttgctgt  1740
agaatttga  taactctca  ttcgttctt  cagtactcg  gtttcatat  ttgctgttt  1800
tgatggaca  ggaggaatt  gagcctcaa  atttgctgc  cagaatttg  atcaaaact  1860
aatcagaaa  tttcctaaa  gagatgtaa  cagtgtaga  aaaaccgtg  agagatgcc  1920
tttggacac  ttcaagcat  ctgatgaag  gttccttaa  caagcttcc  gccagaagc  1980
tgcctggaa  gatgggtcc  ctgccacgt  tgttctggc  gtagacaac  ttctttata  2040
tgccaacct  ggagatagt  gggcaatct  gtgtcgtta  aatgaggag  gtcaaaaac  2100
tgcagcctt  agcctcagc  aagagcata  tccaactca  tatgaagag  ggatgagga  2160
acagaaggc  ggaggaaac  tcagggatg  gcgtgtttt  ggcgtgcta  aggtgtcac  2220
ctccattgg  gacgggcag  acaagcgct  cggtgtcac  tctgtgccc  acatcagac  2280
ctgccagct  acccccaat  acaggttca  tttgttggc  tgtgatggg  tcttcaagg  2340
ctttacccc  gaagaagcc  tgaacttca  cttgtcctg  ctcgaggat  aaaagatcc  2400
gacccggga  gggaagtcc  cagccgacg  ccgctacga  gcagcctgc  acaggctgg  2460
caacaaggc  gtgcagcgg  gctcggccg  caacgtcac  gtgatggtg  tgcggatag  2520
gcactgagg  gtggcgcgc  gccaggagc  cgcatggta  tgacttaaa  ggttcattt  2580
gtgtgtgtg  acattgtgt  ttttgtgta  tcctgtggg  ctcccatgg  tgtaaataa  2640
ggtttctct  tttt  2654



<210> 1275
<211> 392
<212> PRT
<213> Homo sapiens
<308> NP_110395
<400> 1275

Met Asp Leu Phe Gly Asp Leu Pro Glu Pro Glu Arg Ser Pro Arg Pro 
  1               5                  10                  15
Ala Ala Gly Lys Glu Ala Gln Lys Gly Pro Leu Leu Phe Asp Asp Leu 
             20                  25                  30
Pro Pro Ala Ser Ser Thr Asp Ser Gly Ser Gly Gly Pro Leu Leu Phe 
         35                  40                  45
Asp Asp Leu Pro Pro Ala Ser Ser Gly Asp Ser Gly Ser Leu Ala Thr 
     50                  55                  60
Ser Ile Ser Gln Met Val Lys Thr Glu Gly Lys Gly Ala Lys Arg Lys 
 65                  70                  75                  80
Thr Ser Glu Glu Glu Lys Asn Gly Ser Glu Glu Leu Val Glu Lys Lys 
                 85                  90                  95
Val Cys Lys Ala Ser Ser Val Ile Phe Gly Leu Lys Gly Tyr Val Ala 
             100                105                110
Glu Arg Lys Gly Glu Arg Glu Glu Met Gln Asp Ala His Val Ile Leu 
         115                120                125
Asn Asp Ile Thr Glu Glu Cys Arg Pro Pro Ser Ser Leu Ile Thr Arg 
     130                135                140
Val Ser Tyr Phe Ala Val Phe Asp Gly His Gly Gly Ile Arg Ala Ser 
 145                150                155                160
Lys Phe Ala Ala Gln Asn Leu His Gln Asn Leu Ile Arg Lys Phe Pro 
                 165                170                175
Lys Gly Asp Val Ile Ser Val Glu Lys Thr Val Lys Arg Cys Leu Leu 
             180                185                190
Asp Thr Phe Lys His Thr Asp Glu Glu Phe Leu Lys Gln Ala Ser Ser 
         195                200                205
Gln Lys Pro Ala Trp Lys Asp Gly Ser Thr Ala Thr Cys Val Leu Ala 
     210                215                220
Val Asp Asn Ile Leu Tyr Ile Ala Asn Leu Gly Asp Ser Arg Ala Ile 
 225                230                235                240
Leu Cys Arg Tyr Asn Glu Glu Ser Gln Lys His Ala Ala Leu Ser Leu 
                 245                250                255
Ser Lys Glu His Asn Pro Thr Gln Tyr Glu Glu Arg Met Arg Ile Gln 
             260                265                270
Lys Ala Gly Gly Asn Val Arg Asp Gly Arg Val Leu Gly Val Leu Glu 
         275                280                285
Val Ser Arg Ser Ile Gly Asp Gly Gln Tyr Lys Arg Cys Gly Val Thr 
     290                295                300
Ser Val Pro Asp Ile Arg Arg Cys Gln Leu Thr Pro Asn Asp Arg Phe 
 305                310                315                320
Ile Leu Leu Ala Cys Asp Gly Leu Phe Lys Val Phe Thr Pro Glu Glu 
                 325                330                335
Ala Val Asn Phe Ile Leu Ser Cys Leu Glu Asp Glu Lys Ile Gln Thr 
             340                345                350
Arg Glu Gly Lys Ser Ala Ala Asp Ala Arg Tyr Glu Ala Ala Cys Asn 
         355                360                365
Arg Leu Ala Asn Lys Ala Val Gln Arg Gly Ser Ala Asp Asn Val Thr 
     370                375                380
Val Met Val Val Arg Ile Gly His 
 385                390



<210> 1276
<211> 1318
<212> DNA
<213> Rattus norvegicus
<308> AF095927
<400> 1276

cgccgccca  gctagcgcg  gcctccgct  catcgcccc  ccgccatgg  cctattcgg  60
gacttgccg  agcccgagc  cccgccgcg  ccgtctgcc  ggaaagaag  acaggaagg  120
cccgtgctc  tcgaggacc  gcccccgac  agcagtact  actcaggat  tgggggacc  180
ttactcttt  atggtcttc  acctgctgg  agcggcaat  caggttctc  tgccacatc  240
ggctcccag  tggtgaaga  cgaaggaaa  ggagcaaag  ggaaagccc  tgaggaaga  300
aagaatggc  gtgaagagc  tgtggaaaa  aaagtttgt  aagcctctt  ggtgatctt  360
ggtttgaaa  gctacgtgg  agagcggaa  ggtgagagg  aggagatgc  ggacgccca  420
gtcatcctg  atgatatca  tcaggagtg  aatcctcca  catctctca  tactcgggt  480
tcatacttt  ctgtttttg  tggacatgg  ggaattcga  cctcgaaat  tgctgcaca  540
aatttgcac  agaacttaa  caggaaatt  cctaaagga  atgtaatca  tgtggagaa  600
actgtgaag  ggtgcctgc  agatacttt  aagcacacc  atgaagagt  cctgaaaca  660
gcttcaagc  agaagcctg  ctggaaaga  gggtccact  ccacgtgtg  cctggctgt  720
gacaacatc  tgtatatcg  caaccttgg  gatagtcgg  caatcctgt  tcgatataa  780
gaggaaagt  aaaagcatg  agccttaag  ctcagcaaa  agcacaatc  aactcagta  840
gaagagcgc  tgaggatac  gaaggctgg  ggcaatgtc  gagatggcc  tgtcttggg  900
gtgctggag  tatcccgct  cattggaga  gggcagtac  agcgttgcg  ggtcacatc  960
gtgcctgat  tcagacgct  ccagttgac  cccaatgac  ggttcattt  gctggcttg  1020
gatgggctc  tcaaggtct  taccccaga  gaagctgtg  acttcatct  gtcctgcct  1080
gaggatgag  agatccaga  ccgagaagg  aagcctgct  ttgatgccc  ctatgaagc  1140
gcatgcaac  ggctggcta  caaggcagt  cagcggggc  cggcagata  cgtgacggt  1200
atggtggtg  ggataggac  ctgaggccg  acactgcac  tgtgctctt  acttgcagg  1260
tcatcttgt  tgtgcacgc  gtgtgtact  ctgtggggc  tctatggtt  taaataaa  1318



<210> 1277
<211> 392
<212> PRT
<213> Rattus norvegicus
<308> AAC97497
<400> 1277

Met Asp Leu Phe Gly Asp Leu Pro Glu Pro Glu Arg Pro Pro Arg Pro 
  1               5                  10                  15
Ser Ala Gly Lys Glu Ala Gln Glu Gly Pro Val Leu Phe Glu Asp Leu 
             20                  25                  30
Pro Pro Thr Ser Ser Thr Asp Ser Gly Ser Gly Gly Pro Leu Leu Phe 
         35                  40                  45
Asp Gly Leu Pro Pro Ala Gly Ser Gly Asn Ser Gly Ser Leu Ala Thr 
     50                  55                  60
Ser Gly Ser Gln Val Val Lys Asn Glu Gly Lys Gly Ala Lys Arg Lys 
 65                  70                  75                  80
Ala Pro Glu Glu Glu Lys Asn Gly Gly Glu Glu Leu Val Glu Lys Lys 
                 85                  90                  95
Val Cys Lys Ala Ser Ser Val Ile Phe Gly Leu Lys Gly Tyr Val Ala 
             100                105                110
Glu Arg Lys Gly Glu Arg Glu Glu Met Gln Asp Ala His Val Ile Leu 
         115                120                125
Asn Asp Ile Thr Gln Glu Cys Asn Pro Pro Ser Ser Leu Ile Thr Arg 
     130                135                140
Val Ser Tyr Phe Ala Val Phe Asp Gly His Gly Gly Ile Arg Ala Ser 
 145                150                155                160
Lys Phe Ala Ala Gln Asn Leu His Gln Asn Leu Ile Arg Lys Phe Pro 
                 165                170                175
Lys Gly Asp Val Ile Ser Val Glu Lys Thr Val Lys Arg Cys Leu Leu 
             180                185                190
Asp Thr Phe Lys His Thr Asp Glu Glu Phe Leu Lys Gln Ala Ser Ser 
         195                200                205
Gln Lys Pro Ala Trp Lys Asp Gly Ser Thr Ala Thr Cys Val Leu Ala 
     210                215                220
Val Asp Asn Ile Leu Tyr Ile Ala Asn Leu Gly Asp Ser Arg Ala Ile 
 225                230                235                240
Leu Cys Arg Tyr Asn Glu Glu Ser Gln Lys His Ala Ala Leu Ser Leu 
                 245                250                255
Ser Lys Glu His Asn Pro Thr Gln Tyr Glu Glu Arg Met Arg Ile Gln 
             260                265                270
Lys Ala Gly Gly Asn Val Arg Asp Gly Arg Val Leu Gly Val Leu Glu 
         275                280                285
Val Ser Arg Ser Ile Gly Asp Gly Gln Tyr Lys Arg Cys Gly Val Thr 
     290                295                300
Ser Val Pro Asp Ile Arg Arg Cys Gln Leu Thr Pro Asn Asp Arg Phe 
 305                310                315                320
Ile Leu Leu Ala Cys Asp Gly Leu Phe Lys Val Phe Thr Pro Glu Glu 
                 325                330                335
Ala Val Asn Phe Ile Leu Ser Cys Leu Glu Asp Glu Lys Ile Gln Thr 
             340                345                350
Arg Glu Gly Lys Pro Ala Val Asp Ala Arg Tyr Glu Ala Ala Cys Asn 
         355                360                365
Arg Leu Ala Asn Lys Ala Val Gln Arg Gly Ser Ala Asp Asn Val Thr 
     370                375                380
Val Met Val Val Arg Ile Gly His 
 385                390



<210> 1278
<211> 2654
<212> DNA
<213> Homo sapiens
<308> AK055417
<400> 1278

cttgtctca  agtcctggg  tcaagccat  ttcccacct  ggtctccca  agtgccagg  60
ttactcgca  gagccacca  acccagcct  ggatttgca  taaaaccag  aaagggacc  120
ctggagccc  agaaggcag  tccattgag  gtaaattta  ttgggaaca  tacatcatg  180
cttgcaaat  acaggcagt  agaacagct  tgagttata  accagacga  gtttttttt  240
tcatggctc  ggatgtcct  aattgaaaa  gaattccaa  aaacttgaa  gaaaagcag  300
tctctagaa  aaatgtcat  tctcgtggg  atttttgtt  ttttttttt  cttgaaata  360
tttatttga  gtcttttat  ccatatatg  gggttttct  gcaaaattt  aaaggggaa  420
gggaataag  gtagtaaga  aggttttaa  aatgagata  ttagaattt  tttgagtaa  480
aattctgta  tatcctccc  gctcttatg  agtcatgtg  tgaataaca  catcaagtc  540
gtgatggac  gcatatatg  cggtgctcc  ataagatta  aaattttgt  gagatgggg  600
tctcgctat  ttgcccagg  tggtcttga  ctcctggcc  caagtgatc  tcctgcctt  660
gccacctcc  gaagtgttg  gattaacag  cgtgagctg  cgtgttcag  cataatacc  720
tgtttactg  accttttct  tgtttaggt  tgtttaaat  cacaaatac  accagtgtg  780
tacaactgc  tatggtatt  agtgcagta  catgctgtg  agtttagcc  aggagcaat  840
ggctctacc  tgtatgtag  ttaggtgtg  agtaagctg  gccgcgtta  tttctgtaa  900
tatgttcta  gatgttcac  caacaaagt  acctaacaa  gcatttctg  taagtgatg  960
atgactgta  tttttactg  tttcgataa  taacttgat  tgtttgtta  tgtttaaaa  1020
caaatccga  ttaaatagg  acggagttc  gaattttag  tttgttgtc  gtgaaaaat  1080
agaattaac  gatcttgat  tttgaagca  atgtgagtt  taaacattt  atgtaaaat  1140
ctgggaaaa  tgttacatc  cttttagaa  attagacct  tagcaggtc  tgcagtctt  1200
accagaaac  ctcccacac  tacacacac  cagtgtttt  gtttttttt  tttttttta  1260
acagaatct  gctctgtca  cccggctga  gtgcagtgg  gcgatctca  ttcactgca  1320
gctccgcct  ctgggttca  gccattctc  tgcctcagc  tcccgagta  ctgggactg  1380
aggtgcctg  caccgcgcc  ggctaattt  tttgtattg  tagtagaga  ggggtttca  1440
cgtgttagc  aggatggtc  tgatctcct  atctcgtga  ccgcctgcc  cggcctccc  1500
aagcgctgg  attacaggc  tgagccccc  cacctggcc  acacacaag  atttttttt  1560
taaaaaaag  taaaatgct  tgaaagtta  ttaaatatt  gtctcagtt  aagcctttt  1620
tttcccatt  gtaacagtg  gactggtgt  ttaaccagt  tgacttcct  tgacttatt  1680
atgttcact  tttgagacg  aatttaaaa  ctttaatgg  aaagtgtgg  ttttgctgt  1740
agaatttga  taactctca  ttcgttctt  cagtactcg  gtttcatat  ttgctgttt  1800
tgatggaca  ggaggaatt  gagcctcaa  atttgctgc  cagaatttg  atcaaaact  1860
aatcagaaa  tttcctaaa  gagatgtaa  cagtgtaga  aaaaccgtg  agagatgcc  1920
tttggacac  ttcaagcat  ctgatgaag  gttccttaa  caagcttcc  gccagaagc  1980
tgcctggaa  gatgggtcc  ctgccacgt  tgttctggc  gtagacaac  ttctttata  2040
tgccaacct  ggagatagt  gggcaatct  gtgtcgtta  aatgaggag  gtcaaaaac  2100
tgcagcctt  agcctcagc  aagagcata  tccaactca  tatgaagag  ggatgagga  2160
acagaaggc  ggaggaaac  tcagggatg  gcgtgtttt  ggcgtgcta  aggtgtcac  2220
ctccattgg  gacgggcag  acaagcgct  cggtgtcac  tctgtgccc  acatcagac  2280
ctgccagct  acccccaat  acaggttca  tttgttggc  tgtgatggg  tcttcaagg  2340
ctttacccc  gaagaagcc  tgaacttca  cttgtcctg  ctcgaggat  aaaagatcc  2400
gacccggga  gggaagtcc  cagccgacg  ccgctacga  gcagcctgc  acaggctgg  2460
caacaaggc  gtgcagcgg  gctcggccg  caacgtcac  gtgatggtg  tgcggatag  2520
gcactgagg  gtggcgcgc  gccaggagc  cgcatggta  tgacttaaa  ggttcattt  2580
gtgtgtgtg  acattgtgt  ttttgtgta  tcctgtggg  ctcccatgg  tgtaaataa  2640
ggtttctct  tttt  2654



<210> 1279
<211> 392
<212> PRT
<213> Homo sapiens
<308> NP_110395
<400> 1279

Met Asp Leu Phe Gly Asp Leu Pro Glu Pro Glu Arg Ser Pro Arg Pro 
  1               5                  10                  15
Ala Ala Gly Lys Glu Ala Gln Lys Gly Pro Leu Leu Phe Asp Asp Leu 
             20                  25                  30
Pro Pro Ala Ser Ser Thr Asp Ser Gly Ser Gly Gly Pro Leu Leu Phe 
         35                  40                  45
Asp Asp Leu Pro Pro Ala Ser Ser Gly Asp Ser Gly Ser Leu Ala Thr 
     50                  55                  60
Ser Ile Ser Gln Met Val Lys Thr Glu Gly Lys Gly Ala Lys Arg Lys 
 65                  70                  75                  80
Thr Ser Glu Glu Glu Lys Asn Gly Ser Glu Glu Leu Val Glu Lys Lys 
                 85                  90                  95
Val Cys Lys Ala Ser Ser Val Ile Phe Gly Leu Lys Gly Tyr Val Ala 
             100                105                110
Glu Arg Lys Gly Glu Arg Glu Glu Met Gln Asp Ala His Val Ile Leu 
         115                120                125
Asn Asp Ile Thr Glu Glu Cys Arg Pro Pro Ser Ser Leu Ile Thr Arg 
     130                135                140
Val Ser Tyr Phe Ala Val Phe Asp Gly His Gly Gly Ile Arg Ala Ser 
 145                150                155                160
Lys Phe Ala Ala Gln Asn Leu His Gln Asn Leu Ile Arg Lys Phe Pro 
                 165                170                175
Lys Gly Asp Val Ile Ser Val Glu Lys Thr Val Lys Arg Cys Leu Leu 
             180                185                190
Asp Thr Phe Lys His Thr Asp Glu Glu Phe Leu Lys Gln Ala Ser Ser 
         195                200                205
Gln Lys Pro Ala Trp Lys Asp Gly Ser Thr Ala Thr Cys Val Leu Ala 
     210                215                220
Val Asp Asn Ile Leu Tyr Ile Ala Asn Leu Gly Asp Ser Arg Ala Ile 
 225                230                235                240
Leu Cys Arg Tyr Asn Glu Glu Ser Gln Lys His Ala Ala Leu Ser Leu 
                 245                250                255
Ser Lys Glu His Asn Pro Thr Gln Tyr Glu Glu Arg Met Arg Ile Gln 
             260                265                270
Lys Ala Gly Gly Asn Val Arg Asp Gly Arg Val Leu Gly Val Leu Glu 
         275                280                285
Val Ser Arg Ser Ile Gly Asp Gly Gln Tyr Lys Arg Cys Gly Val Thr 
     290                295                300
Ser Val Pro Asp Ile Arg Arg Cys Gln Leu Thr Pro Asn Asp Arg Phe 
 305                310                315                320
Ile Leu Leu Ala Cys Asp Gly Leu Phe Lys Val Phe Thr Pro Glu Glu 
                 325                330                335
Ala Val Asn Phe Ile Leu Ser Cys Leu Glu Asp Glu Lys Ile Gln Thr 
             340                345                350
Arg Glu Gly Lys Ser Ala Ala Asp Ala Arg Tyr Glu Ala Ala Cys Asn 
         355                360                365
Arg Leu Ala Asn Lys Ala Val Gln Arg Gly Ser Ala Asp Asn Val Thr 
     370                375                380
Val Met Val Val Arg Ile Gly His 
 385                390



<210> 1280
<211> 1318
<212> DNA
<213> Rattus norvegicus
<308> AF095927
<400> 1280

cgccgccca  gctagcgcg  gcctccgct  catcgcccc  ccgccatgg  cctattcgg  60
gacttgccg  agcccgagc  cccgccgcg  ccgtctgcc  ggaaagaag  acaggaagg  120
cccgtgctc  tcgaggacc  gcccccgac  agcagtact  actcaggat  tgggggacc  180
ttactcttt  atggtcttc  acctgctgg  agcggcaat  caggttctc  tgccacatc  240
ggctcccag  tggtgaaga  cgaaggaaa  ggagcaaag  ggaaagccc  tgaggaaga  300
aagaatggc  gtgaagagc  tgtggaaaa  aaagtttgt  aagcctctt  ggtgatctt  360
ggtttgaaa  gctacgtgg  agagcggaa  ggtgagagg  aggagatgc  ggacgccca  420
gtcatcctg  atgatatca  tcaggagtg  aatcctcca  catctctca  tactcgggt  480
tcatacttt  ctgtttttg  tggacatgg  ggaattcga  cctcgaaat  tgctgcaca  540
aatttgcac  agaacttaa  caggaaatt  cctaaagga  atgtaatca  tgtggagaa  600
actgtgaag  ggtgcctgc  agatacttt  aagcacacc  atgaagagt  cctgaaaca  660
gcttcaagc  agaagcctg  ctggaaaga  gggtccact  ccacgtgtg  cctggctgt  720
gacaacatc  tgtatatcg  caaccttgg  gatagtcgg  caatcctgt  tcgatataa  780
gaggaaagt  aaaagcatg  agccttaag  ctcagcaaa  agcacaatc  aactcagta  840
gaagagcgc  tgaggatac  gaaggctgg  ggcaatgtc  gagatggcc  tgtcttggg  900
gtgctggag  tatcccgct  cattggaga  gggcagtac  agcgttgcg  ggtcacatc  960
gtgcctgat  tcagacgct  ccagttgac  cccaatgac  ggttcattt  gctggcttg  1020
gatgggctc  tcaaggtct  taccccaga  gaagctgtg  acttcatct  gtcctgcct  1080
gaggatgag  agatccaga  ccgagaagg  aagcctgct  ttgatgccc  ctatgaagc  1140
gcatgcaac  ggctggcta  caaggcagt  cagcggggc  cggcagata  cgtgacggt  1200
atggtggtg  ggataggac  ctgaggccg  acactgcac  tgtgctctt  acttgcagg  1260
tcatcttgt  tgtgcacgc  gtgtgtact  ctgtggggc  tctatggtt  taaataaa  1318



<210> 1281
<211> 392
<212> PRT
<213> Rattus norvegicus
<308> AAC97497
<400> 1281

Met Asp Leu Phe Gly Asp Leu Pro Glu Pro Glu Arg Pro Pro Arg Pro 
  1               5                  10                  15
Ser Ala Gly Lys Glu Ala Gln Glu Gly Pro Val Leu Phe Glu Asp Leu 
             20                  25                  30
Pro Pro Thr Ser Ser Thr Asp Ser Gly Ser Gly Gly Pro Leu Leu Phe 
         35                  40                  45
Asp Gly Leu Pro Pro Ala Gly Ser Gly Asn Ser Gly Ser Leu Ala Thr 
     50                  55                  60
Ser Gly Ser Gln Val Val Lys Asn Glu Gly Lys Gly Ala Lys Arg Lys 
 65                  70                  75                  80
Ala Pro Glu Glu Glu Lys Asn Gly Gly Glu Glu Leu Val Glu Lys Lys 
                 85                  90                  95
Val Cys Lys Ala Ser Ser Val Ile Phe Gly Leu Lys Gly Tyr Val Ala 
             100                105                110
Glu Arg Lys Gly Glu Arg Glu Glu Met Gln Asp Ala His Val Ile Leu 
         115                120                125
Asn Asp Ile Thr Gln Glu Cys Asn Pro Pro Ser Ser Leu Ile Thr Arg 
     130                135                140
Val Ser Tyr Phe Ala Val Phe Asp Gly His Gly Gly Ile Arg Ala Ser 
 145                150                155                160
Lys Phe Ala Ala Gln Asn Leu His Gln Asn Leu Ile Arg Lys Phe Pro 
                 165                170                175
Lys Gly Asp Val Ile Ser Val Glu Lys Thr Val Lys Arg Cys Leu Leu 
             180                185                190
Asp Thr Phe Lys His Thr Asp Glu Glu Phe Leu Lys Gln Ala Ser Ser 
         195                200                205
Gln Lys Pro Ala Trp Lys Asp Gly Ser Thr Ala Thr Cys Val Leu Ala 
     210                215                220
Val Asp Asn Ile Leu Tyr Ile Ala Asn Leu Gly Asp Ser Arg Ala Ile 
 225                230                235                240
Leu Cys Arg Tyr Asn Glu Glu Ser Gln Lys His Ala Ala Leu Ser Leu 
                 245                250                255
Ser Lys Glu His Asn Pro Thr Gln Tyr Glu Glu Arg Met Arg Ile Gln 
             260                265                270
Lys Ala Gly Gly Asn Val Arg Asp Gly Arg Val Leu Gly Val Leu Glu 
         275                280                285
Val Ser Arg Ser Ile Gly Asp Gly Gln Tyr Lys Arg Cys Gly Val Thr 
     290                295                300
Ser Val Pro Asp Ile Arg Arg Cys Gln Leu Thr Pro Asn Asp Arg Phe 
 305                310                315                320
Ile Leu Leu Ala Cys Asp Gly Leu Phe Lys Val Phe Thr Pro Glu Glu 
                 325                330                335
Ala Val Asn Phe Ile Leu Ser Cys Leu Glu Asp Glu Lys Ile Gln Thr 
             340                345                350
Arg Glu Gly Lys Pro Ala Val Asp Ala Arg Tyr Glu Ala Ala Cys Asn 
         355                360                365
Arg Leu Ala Asn Lys Ala Val Gln Arg Gly Ser Ala Asp Asn Val Thr 
     370                375                380
Val Met Val Val Arg Ile Gly His 
 385                390



<210> 1282
<211> 2654
<212> DNA
<213> Homo sapiens
<308> AK055417
<400> 1282

cttgtctca  agtcctggg  tcaagccat  ttcccacct  ggtctccca  agtgccagg  60
ttactcgca  gagccacca  acccagcct  ggatttgca  taaaaccag  aaagggacc  120
ctggagccc  agaaggcag  tccattgag  gtaaattta  ttgggaaca  tacatcatg  180
cttgcaaat  acaggcagt  agaacagct  tgagttata  accagacga  gtttttttt  240
tcatggctc  ggatgtcct  aattgaaaa  gaattccaa  aaacttgaa  gaaaagcag  300
tctctagaa  aaatgtcat  tctcgtggg  atttttgtt  ttttttttt  cttgaaata  360
tttatttga  gtcttttat  ccatatatg  gggttttct  gcaaaattt  aaaggggaa  420
gggaataag  gtagtaaga  aggttttaa  aatgagata  ttagaattt  tttgagtaa  480
aattctgta  tatcctccc  gctcttatg  agtcatgtg  tgaataaca  catcaagtc  540
gtgatggac  gcatatatg  cggtgctcc  ataagatta  aaattttgt  gagatgggg  600
tctcgctat  ttgcccagg  tggtcttga  ctcctggcc  caagtgatc  tcctgcctt  660
gccacctcc  gaagtgttg  gattaacag  cgtgagctg  cgtgttcag  cataatacc  720
tgtttactg  accttttct  tgtttaggt  tgtttaaat  cacaaatac  accagtgtg  780
tacaactgc  tatggtatt  agtgcagta  catgctgtg  agtttagcc  aggagcaat  840
ggctctacc  tgtatgtag  ttaggtgtg  agtaagctg  gccgcgtta  tttctgtaa  900
tatgttcta  gatgttcac  caacaaagt  acctaacaa  gcatttctg  taagtgatg  960
atgactgta  tttttactg  tttcgataa  taacttgat  tgtttgtta  tgtttaaaa  1020
caaatccga  ttaaatagg  acggagttc  gaattttag  tttgttgtc  gtgaaaaat  1080
agaattaac  gatcttgat  tttgaagca  atgtgagtt  taaacattt  atgtaaaat  1140
ctgggaaaa  tgttacatc  cttttagaa  attagacct  tagcaggtc  tgcagtctt  1200
accagaaac  ctcccacac  tacacacac  cagtgtttt  gtttttttt  tttttttta  1260
acagaatct  gctctgtca  cccggctga  gtgcagtgg  gcgatctca  ttcactgca  1320
gctccgcct  ctgggttca  gccattctc  tgcctcagc  tcccgagta  ctgggactg  1380
aggtgcctg  caccgcgcc  ggctaattt  tttgtattg  tagtagaga  ggggtttca  1440
cgtgttagc  aggatggtc  tgatctcct  atctcgtga  ccgcctgcc  cggcctccc  1500
aagcgctgg  attacaggc  tgagccccc  cacctggcc  acacacaag  atttttttt  1560
taaaaaaag  taaaatgct  tgaaagtta  ttaaatatt  gtctcagtt  aagcctttt  1620
tttcccatt  gtaacagtg  gactggtgt  ttaaccagt  tgacttcct  tgacttatt  1680
atgttcact  tttgagacg  aatttaaaa  ctttaatgg  aaagtgtgg  ttttgctgt  1740
agaatttga  taactctca  ttcgttctt  cagtactcg  gtttcatat  ttgctgttt  1800
tgatggaca  ggaggaatt  gagcctcaa  atttgctgc  cagaatttg  atcaaaact  1860
aatcagaaa  tttcctaaa  gagatgtaa  cagtgtaga  aaaaccgtg  agagatgcc  1920
tttggacac  ttcaagcat  ctgatgaag  gttccttaa  caagcttcc  gccagaagc  1980
tgcctggaa  gatgggtcc  ctgccacgt  tgttctggc  gtagacaac  ttctttata  2040
tgccaacct  ggagatagt  gggcaatct  gtgtcgtta  aatgaggag  gtcaaaaac  2100
tgcagcctt  agcctcagc  aagagcata  tccaactca  tatgaagag  ggatgagga  2160
acagaaggc  ggaggaaac  tcagggatg  gcgtgtttt  ggcgtgcta  aggtgtcac  2220
ctccattgg  gacgggcag  acaagcgct  cggtgtcac  tctgtgccc  acatcagac  2280
ctgccagct  acccccaat  acaggttca  tttgttggc  tgtgatggg  tcttcaagg  2340
ctttacccc  gaagaagcc  tgaacttca  cttgtcctg  ctcgaggat  aaaagatcc  2400
gacccggga  gggaagtcc  cagccgacg  ccgctacga  gcagcctgc  acaggctgg  2460
caacaaggc  gtgcagcgg  gctcggccg  caacgtcac  gtgatggtg  tgcggatag  2520
gcactgagg  gtggcgcgc  gccaggagc  cgcatggta  tgacttaaa  ggttcattt  2580
gtgtgtgtg  acattgtgt  ttttgtgta  tcctgtggg  ctcccatgg  tgtaaataa  2640
ggtttctct  tttt  2654



<210> 1283
<211> 392
<212> PRT
<213> Homo sapiens
<308> NP_110395
<400> 1283

Met Asp Leu Phe Gly Asp Leu Pro Glu Pro Glu Arg Ser Pro Arg Pro 
  1               5                  10                  15
Ala Ala Gly Lys Glu Ala Gln Lys Gly Pro Leu Leu Phe Asp Asp Leu 
             20                  25                  30
Pro Pro Ala Ser Ser Thr Asp Ser Gly Ser Gly Gly Pro Leu Leu Phe 
         35                  40                  45
Asp Asp Leu Pro Pro Ala Ser Ser Gly Asp Ser Gly Ser Leu Ala Thr 
     50                  55                  60
Ser Ile Ser Gln Met Val Lys Thr Glu Gly Lys Gly Ala Lys Arg Lys 
 65                  70                  75                  80
Thr Ser Glu Glu Glu Lys Asn Gly Ser Glu Glu Leu Val Glu Lys Lys 
                 85                  90                  95
Val Cys Lys Ala Ser Ser Val Ile Phe Gly Leu Lys Gly Tyr Val Ala 
             100                105                110
Glu Arg Lys Gly Glu Arg Glu Glu Met Gln Asp Ala His Val Ile Leu 
         115                120                125
Asn Asp Ile Thr Glu Glu Cys Arg Pro Pro Ser Ser Leu Ile Thr Arg 
     130                135                140
Val Ser Tyr Phe Ala Val Phe Asp Gly His Gly Gly Ile Arg Ala Ser 
 145                150                155                160
Lys Phe Ala Ala Gln Asn Leu His Gln Asn Leu Ile Arg Lys Phe Pro 
                 165                170                175
Lys Gly Asp Val Ile Ser Val Glu Lys Thr Val Lys Arg Cys Leu Leu 
             180                185                190
Asp Thr Phe Lys His Thr Asp Glu Glu Phe Leu Lys Gln Ala Ser Ser 
         195                200                205
Gln Lys Pro Ala Trp Lys Asp Gly Ser Thr Ala Thr Cys Val Leu Ala 
     210                215                220
Val Asp Asn Ile Leu Tyr Ile Ala Asn Leu Gly Asp Ser Arg Ala Ile 
 225                230                235                240
Leu Cys Arg Tyr Asn Glu Glu Ser Gln Lys His Ala Ala Leu Ser Leu 
                 245                250                255
Ser Lys Glu His Asn Pro Thr Gln Tyr Glu Glu Arg Met Arg Ile Gln 
             260                265                270
Lys Ala Gly Gly Asn Val Arg Asp Gly Arg Val Leu Gly Val Leu Glu 
         275                280                285
Val Ser Arg Ser Ile Gly Asp Gly Gln Tyr Lys Arg Cys Gly Val Thr 
     290                295                300
Ser Val Pro Asp Ile Arg Arg Cys Gln Leu Thr Pro Asn Asp Arg Phe 
 305                310                315                320
Ile Leu Leu Ala Cys Asp Gly Leu Phe Lys Val Phe Thr Pro Glu Glu 
                 325                330                335
Ala Val Asn Phe Ile Leu Ser Cys Leu Glu Asp Glu Lys Ile Gln Thr 
             340                345                350
Arg Glu Gly Lys Ser Ala Ala Asp Ala Arg Tyr Glu Ala Ala Cys Asn 
         355                360                365
Arg Leu Ala Asn Lys Ala Val Gln Arg Gly Ser Ala Asp Asn Val Thr 
     370                375                380
Val Met Val Val Arg Ile Gly His 
 385                390



<210> 1284
<211> 4510
<212> DNA
<213> Rattus norvegicus
<308> AF096835
<400> 1284

gcggaaccc  cgctcaatg  gcgatgtct  tacaaggct  tcactcagg  ggcagtggc  60
gagacgtgg  cgggcagct  tgctgctgc  gcgtgaagt  gagaggcgt  ggggtccgt  120
gtgcgcgct  tcggtgctc  aaggctcct  gcggcgaga  gggccggcg  cgaccgcag  180
gtctccatg  ccgctcgtg  ggcgggccg  tgatggagc  cgccaccca  ccccgaccg  240
gcgcgctgc  gctgctgtt  ctgctgctg  gctgcgcgg  ggggatctc  gcggtcgcg  300
gcgcccgca  cttgcttgc  cccacatcg  atacggcat  tggcttggg  gcagcagcc  360
cccctactt  agccgcgcg  gtgcctgcg  tggctacgg  cgaagtgac  gtggaagac  420
ccgaggcat  gcccgctgc  tccggcgaa  aggagtcac  cgcgaccga  tccgatgac  480
acgtggaac  gcggcctcg  ggcaggtcc  tagtaatca  cagcacttt  gatggacga  540
ttgccgcac  ggatgccga  aatcatggg  aaaagcagt  ggatttgga  gtgggatct  600
gttccttgg  ttcatctag  cttagcaag  cagaggtgt  tgggaacaa  atgatcatt  660
cttccctgg  cggagacct  ttccagtgg  accgagacc  agagagcat  gaggccgtc  720
ctttcactg  ggagtccct  ctcgaatct  catacaagt  tggagatga  gttgttctg  780
ttggaggaa  gtctctgac  acatacggg  tcagtgcat  tagtggaaa  ctgaggtat  840
tctgttctg  cttgggatg  cgccgatgg  atagtgatg  aatggaaga  gaggaagac  900
tcttgcttc  gcaacgcac  cagaagact  tgcgagctg  cgggcctcg  agcggcagt  960
agaagtgga  tttcagtgt  ggccacttt  aacttcggt  tattccaga  atggaaact  1020
gagccggat  cattgaaag  acctttaaa  tgggtggaa  caaagaaga  tctaaaatc  1080
tttcagatg  ggaagaaca  gatgtggac  cagtgataa  agtttccgt  gctgattgg  1140
aggtcatgg  gtttagtaa  aagggaggc  gcctagaat  ggagtacca  ttttgtact  1200
ccattgcgt  tgcctggct  gtgagggat  gtaaagtca  ccccatcag  ctgtttgat  1260
acacaagtt  cacagccaa  gaggaagtt  tggaagatg  agaagacat  gtagaggct  1320
ctcggggag  cacagagaa  agcgtgtac  tagggatgt  cagaggcca  ctgtacctg  1380
aatcatccg  cagggtctc  gaaaagttc  ctacaaggc  gaaggcctt  gagtctgta  1440
atggagaaa  tgccattat  cctctgccg  cgatcaaat  gaagccctt  atccattct  1500
cgtctagga  tcctgtctt  gttgggtct  atgaatttg  caagtgtct  agtaatgat  1560
aatattccc  tgaagaata  agtaatggt  cgctttcaa  cctacagta  ccatatgac  1620
acggttact  tctgcctta  tacaagaga  aaaggaata  gcggagcac  cagatcacg  1680
tcaggttcc  ggacagccc  cactacagc  agaacatcc  caagaagga  cccatcctc  1740
tcctgcact  gtggaagga  atatttgga  cgatcttgc  ttgcattgt  gccacgacc  1800
ttatcgtgc  caggctttt  catcctcag  cccacaggc  acggaagga  tctgaaact  1860
agtgccaaa  tgaaagtaa  tacgactct  tgagtgctg  taacagcga  aacagctgg  1920
acgacatta  acactcagg  tacgtgtcc  gatacctaa  agattttga  ccaattcag  1980
gcatgggtc  aggcggctt  ggcgttgtc  ttgaagcta  gaacaaagt  gatgactgc  2040
attacgcca  caagaggat  cgtctccca  acagggagc  ggcacggga  aaggtaatg  2100
gggaagtca  agccttggc  aagctggag  acccaggca  cgtgaggta  ttcaatgcg  2160
ggctggaaa  accaccaga  aagtggcaa  aggagatgg  tgaaatctg  ctgaaggac  2220
aaagcacag  ctggccact  agctcccct  gcccaatgg  tgccccatc  gttaagatc  2280
ggcagatgg  tcctttctc  acaaaagaa  agattgaag  catagctcc  tctcctgaa  2340
gaagtcggt  tttctcagt  ggcatttcc  gtggccgga  aagctcatc  gagagccag  2400
tctctcccc  ggagttctc  gggacagac  gtggagaca  cagtgactc  gaggacgca  2460
cccacaacc  ccaggacag  tgcctgaca  attgcgaca  ggaagatgg  acagtggac  2520
gcgatgatg  gggacactc  tttgaactt  gtccttctg  agcttctcc  tataccagg  2580
caagggagg  aacgtcctc  tccatagtg  ttgaagact  tggctgtga  aatgcgtcc  2640
gtaaggagg  ccccagaat  aatcggctg  ataatggcc  ccattacgt  aataagcta  2700
ctgagttca  gcactccag  agcaggtct  cttccgaag  caccttgtc  acctctcct  2760
ccaggccaa  caccctaag  ttagatttc  ccaggaaca  ggtggaccg  ctccagccc  2820
gctccccca  ggtgtacct  tacatccag  tgcagctgt  caggaagga  aaccttaaa  2880
actggatga  ccggcgctg  agcatggag  acagggagc  cagagtgtg  ctgcacatc  2940
ttctgcaga  cgcagaggc  gtgcagttt  tgcacagca  gggactcat  cacagggac  3000
tcaagcctt  caacatatt  ttcacaatg  atgatgtgg  caaagttgg  gactttggg  3060
tagtgactg  aatggacca  gatgaagaa  agcagacag  actgactcc  atgccagcc  3120
atgctacac  cacgggaca  gtcgggacc  agctgtaca  gagcccaga  cagattcat  3180
gaaacaact  ctcccataa  gtggacatc  tctctttag  cttgattct  tttgaactc  3240
tttacccat  cagcactca  atggaacga  ttaggactt  aactgatgt  agaaatctc  3300
agtttccac  actgttcac  cagaaatat  cccaagagc  tatgatggt  caagacatg  3360
tttctccat  ccccatgga  cggcctgaa  ccacagaca  cattgaaaa  gctgtgttt  3420
agaacttgg  gtttcctgg  aaaacggtt  tgagacagc  gtcccgctc  ttgagttca  3480
ccggaacta  acattccag  cagcccagc  gcacattca  cccactgcc  ggcaactag  3540
ctccagctg  gcctgcggc  ctcagaggt  gcacaggac  ggcaccttg  ggaatgtgg  3600
tctccgtgg  ggcggactc  ttttatgct  tgatcaact  gacttagga  caatttttc  3660
aagtcagac  ggattatgg  cctaaccca  tttgatctt  actaaactt  aaggaaagg  3720
ctatataaa  gacaagtgg  tttgtttct  gttggtgtc  caaaactag  tggtcaagc  3780
acagaacct  cacttttca  caggaggca  aagacagcc  gaaaccatc  gaactggaa  3840
tgactttaa  gcacaaagg  gtgaaagac  ctctcacat  ggaactaca  gttctagaa  3900
cgtgctttc  agaaataca  gggtgatta  ggaagcgac  gttataaag  tgactccat  3960
tttgtccct  gtgagcatg  gacccatct  cactatttt  gaaggcgca  cacaggctg  4020
gtggccatt  atgtcagta  tgccatagt  tgcagcagt  aataacttc  ctttttagg  4080
ggtctaggg  gcacggtga  ctttttgta  ttttttatc  ccagtaatg  gaaaatgaa  4140
ctttttagg  attggtcaa  agatctgat  ggagggttt  aaaagaagt  tagtaagaa  4200
tgggtcacc  attacacct  acttattcc  ttatggagt  tttgtccta  tagaagtct  4260
ccttatgtg  aatactaca  gtcagcata  cccccaaac  gattatagg  aagtttaat  4320
atctcaact  gctaacatg  tctcatttt  cctgtaaat  tctttattt  ttatttata  4380
aaattctga  atcaatcca  ttgggttgg  ggtgtacag  atgcacata  gtgtgttaa  4440
tattatgac  tctttcaag  ctaaatgat  taataaaac  tttttaaat  ataaaaaaa  4500
aaaaaaaaaa  4510



<210> 1285
<211> 1108
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1Z1
<400> 1285

Met Glu Arg Ala Thr Gln Pro Arg Pro Arg Ala Leu Leu Leu Leu Phe 
  1               5                  10                  15
Leu Leu Leu Gly Cys Ala Ala Gly Ile Ser Ala Val Ala Arg Ala Arg 
             20                  25                  30
Ser Leu Leu Ala Pro Thr Ser Asp Thr Ala Phe Gly Leu Gly Ala Ala 
         35                  40                  45
Ala Ala Pro Thr Ser Ala Ala Arg Val Pro Ala Val Ala Thr Ala Glu 
     50                  55                  60
Val Thr Val Glu Asp Ala Glu Ala Leu Pro Ala Ala Ser Gly Glu Gln 
 65                  70                  75                  80
Glu Ser Arg Ala Thr Glu Ser Asp Asp Asp Val Glu Leu Arg Pro Arg 
                 85                  90                  95
Gly Arg Ser Leu Val Ile Ile Ser Thr Leu Asp Gly Arg Ile Ala Ala 
             100                105                110
Leu Asp Ala Glu Asn His Gly Lys Lys Gln Trp Asp Leu Asp Val Gly 
         115                120                125
Ser Gly Ser Leu Val Ser Ser Ser Leu Ser Lys Pro Glu Val Phe Gly 
     130                135                140
Asn Lys Met Ile Ile Pro Ser Leu Asp Gly Asp Leu Phe Gln Trp Asp 
 145                150                155                160
Arg Asp Arg Glu Ser Met Glu Ala Val Pro Phe Thr Val Glu Ser Leu 
                 165                170                175
Leu Glu Ser Ser Tyr Lys Phe Gly Asp Asp Val Val Leu Val Gly Gly 
             180                185                190
Lys Ser Leu Thr Thr Tyr Gly Leu Ser Ala Tyr Ser Gly Lys Leu Arg 
         195                200                205
Tyr Ile Cys Ser Ala Leu Gly Cys Arg Arg Trp Asp Ser Asp Glu Met 
     210                215                220
Glu Glu Glu Glu Asp Ile Leu Leu Leu Gln Arg Thr Gln Lys Thr Val 
 225                230                235                240
Arg Ala Val Gly Pro Arg Ser Gly Ser Glu Lys Trp Asn Phe Ser Val 
                 245                250                255
Gly His Phe Glu Leu Arg Tyr Ile Pro Asp Met Glu Thr Arg Ala Gly 
             260                265                270
Phe Ile Glu Ser Thr Phe Lys Leu Gly Gly Asn Lys Glu Asp Ser Lys 
         275                280                285
Ile Ile Ser Asp Val Glu Glu Gln Asp Val Asp Thr Val Ile Lys Val 
     290                295                300
Ser Val Ala Asp Trp Lys Val Met Ala Phe Ser Lys Lys Gly Gly Arg 
 305                310                315                320
Leu Glu Trp Glu Tyr Gln Phe Cys Thr Pro Ile Ala Ser Ala Trp Leu 
                 325                330                335
Val Arg Asp Gly Lys Val Ile Pro Ile Ser Leu Phe Asp Asp Thr Ser 
             340                345                350
Tyr Thr Ala Asn Glu Glu Val Leu Glu Asp Glu Glu Asp Ile Val Glu 
         355                360                365
Ala Ala Arg Gly Ala Thr Glu Asn Ser Val Tyr Leu Gly Met Tyr Arg 
     370                375                380
Gly Gln Leu Tyr Leu Gln Ser Ser Val Arg Val Ser Glu Lys Phe Pro 
 385                390                395                400
Thr Arg Pro Lys Ala Leu Glu Ser Val Asn Gly Glu Ser Ala Ile Ile 
                 405                410                415
Pro Leu Pro Thr Ile Lys Trp Lys Pro Leu Ile His Ser Pro Ser Arg 
             420                425                430
Thr Pro Val Leu Val Gly Ser Asp Glu Phe Asp Lys Cys Leu Ser Asn 
         435                440                445
Asp Lys Tyr Ser His Glu Glu Tyr Ser Asn Gly Ala Leu Ser Ile Leu 
     450                455                460
Gln Tyr Pro Tyr Asp Asn Gly Tyr Tyr Leu Pro Tyr Tyr Lys Arg Glu 
 465                470                475                480
Arg Asn Lys Arg Ser Thr Gln Ile Thr Val Arg Phe Leu Asp Ser Pro 
                 485                490                495
His Tyr Ser Lys Asn Ile Arg Lys Lys Asp Pro Ile Leu Leu Leu His 
             500                505                510
Trp Trp Lys Glu Ile Phe Gly Thr Ile Leu Leu Cys Ile Val Ala Thr 
         515                520                525
Thr Phe Ile Val Arg Arg Leu Phe His Pro Gln Pro His Arg Gln Arg 
     530                535                540
Lys Glu Ser Glu Thr Gln Cys Gln Thr Glu Ser Lys Tyr Asp Ser Val 
 545                550                555                560
Ser Ala Asp Asn Ser Asp Asn Ser Trp Asn Asp Ile Lys His Ser Gly 
                 565                570                575
Tyr Val Ser Arg Tyr Leu Thr Asp Phe Glu Pro Ile Gln Cys Met Gly 
             580                585                590
Arg Gly Gly Phe Gly Val Val Phe Glu Ala Lys Asn Lys Val Asp Asp 
         595                600                605
Cys Asn Tyr Ala Ile Lys Arg Ile Arg Leu Pro Asn Arg Glu Leu Ala 
     610                615                620
Arg Glu Lys Val Met Arg Glu Val Lys Ala Leu Ala Lys Leu Glu His 
 625                630                635                640
Pro Gly Ile Val Arg Tyr Phe Asn Ala Trp Leu Glu Thr Pro Pro Glu 
                 645                650                655
Lys Trp Gln Glu Glu Met Asp Glu Ile Trp Leu Lys Asp Glu Ser Thr 
             660                665                670
Asp Trp Pro Leu Ser Ser Pro Ser Pro Met Asp Ala Pro Ser Val Lys 
         675                680                685
Ile Arg Gln Met Asp Pro Phe Ser Thr Lys Glu Gln Ile Glu Val Ile 
     690                695                700
Ala Pro Ser Pro Glu Arg Ser Arg Ser Phe Ser Val Gly Ile Ser Cys 
 705                710                715                720
Gly Arg Thr Ser Ser Ser Glu Ser Gln Phe Ser Pro Leu Glu Phe Ser 
                 725                730                735
Gly Thr Asp Cys Gly Asp Asn Ser Asp Ser Glu Asp Ala Ala His Asn 
             740                745                750
Leu Gln Asp Ser Cys Leu Thr Asp Cys Asp Met Glu Asp Gly Thr Val 
         755                760                765
Asp Gly Asp Asp Glu Gly His Ser Phe Glu Leu Cys Pro Ser Glu Ala 
     770                775                780
Ser Pro Tyr Thr Arg Ser Arg Glu Gly Thr Ser Ser Ser Ile Val Phe 
 785                790                795                800
Glu Asp Ser Gly Cys Asp Asn Ala Ser Ser Lys Glu Asp Pro Arg Met 
                 805                810                815
Asn Arg Leu His Asn Gly His His Tyr Val Asn Lys Leu Thr Glu Phe 
             820                825                830
Lys His Ser Ser Ser Arg Ser Ser Ser Glu Ala Thr Leu Ser Thr Ser 
         835                840                845
Pro Thr Arg Pro Thr Thr Leu Ser Leu Asp Phe Thr Arg Asn Thr Val 
     850                855                860
Asp Arg Leu Gln Pro Ser Ser Pro Lys Val Tyr Leu Tyr Ile Gln Met 
 865                870                875                880
Gln Leu Cys Arg Lys Glu Asn Leu Lys Asp Trp Met Asn Arg Arg Cys 
                 885                890                895
Ser Met Glu Asp Arg Glu His Arg Val Cys Leu His Ile Phe Leu Gln 
             900                905                910
Ile Ala Glu Ala Val Gln Phe Leu His Ser Lys Gly Leu Met His Arg 
         915                920                925
Asp Leu Lys Pro Ser Asn Ile Phe Phe Thr Met Asp Asp Val Val Lys 
     930                935                940
Val Gly Asp Phe Gly Leu Val Thr Ala Met Asp Gln Asp Glu Glu Glu 
 945                950                955                960
Gln Thr Val Leu Thr Pro Met Pro Ala Tyr Ala Thr His Thr Gly Gln 
                 965                970                975
Val Gly Thr Lys Leu Tyr Met Ser Pro Glu Gln Ile His Gly Asn Asn 
             980                985                990
Tyr Ser His Lys Val Asp Ile Phe Ser Leu Gly Leu Ile Leu Phe Glu 
         995                1000                1005
Leu Leu Tyr Pro Phe Ser Thr Gln Met Glu Arg Val Arg Thr Leu Thr 
     1010                1015                1020
Asp Val Arg Asn Leu Lys Phe Pro Pro Leu Phe Thr Gln Lys Tyr Pro 
 1025                1030                1035                1040
Gln Glu His Met Met Val Gln Asp Met Leu Ser Pro Ser Pro Met Glu 
                 1045                1050                1055
Arg Pro Glu Ala Thr Asp Ile Ile Glu Asn Ala Val Phe Glu Asn Leu 
             1060                1065                1070
Glu Phe Pro Gly Lys Thr Val Leu Arg Gln Arg Ser Arg Ser Leu Ser 
         1075                1080                1085
Ser Ser Gly Thr Lys His Ser Arg Gln Pro Ser Ser Thr Phe Ser Pro 
     1090                1095                1100
Leu Pro Gly Asn 
 1105



<210> 1286
<211> 4325
<212> DNA
<213> Homo sapiens
<308> AF110146
<400> 1286

ggagctcca  gcggcggga  aggcaggcg  cagtggctg  gcctccatg  ctgcgcgcg  60
ggcgggacg  tgatggagc  cgccatcag  ccggggctg  tggtacggg  gctgctgct  120
ctgctgctg  tggggctcg  ggcaaggac  gtggccgcg  ggcgcgccc  tggcctccc  180
gcgccgacg  cggaggcgg  gttcggcct  ggggcggcc  ctgctccca  ctcagcgac  240
cgagtaccg  cggcgggcg  cgtggctgc  gccgaggtg  ctgtggagg  cgctgaggc  300
ctgccggca  ccgcgggag  gcaggagcc  cggggtccg  aaccagacg  tgagacaga  360
ttgcgaccg  gcggcaggt  attagtaat  atcagcact  tagatggga  aattgctgc  420
ttggatcct  aaaatcatg  taaaaagca  tgggatttg  atgtgggat  cggttcctt  480
gtgtcatcc  gccttagca  accagaggt  tttgggaat  agatgatca  tccttccct  540
gatggagcc  tcttccagt  ggaccgaga  cgtgaaagc  tggaaacag  tcctttcac  600
gttgaatca  ttcttgaat  ttcttataa  tttggagat  atgttgttt  ggttggagg  660
aaatctctg  ctacatatg  actcagtgc  tatagtgga  aggtgaggt  tatctgttc  720
gctctgggt  gtcgccaat  ggatagtga  gaaatggaa  aagaggaag  catcctgct  780
ctacagcgt  cccaaaaaa  tgttagagc  gtcggacct  gcagtggca  tgagaagtg  840
aatttcagt  ttggccact  tgaacttcg  tatattcca  acatggaaa  gagagccgg  900
tttattgaa  gcaccttta  gcccaatga  aacacagaa  agtctaaaa  tatttcaga  960
gtggaagaa  aggaagctg  cataatgga  atagtgata  aggtttcgg  tgctgactg  1020
aaagttatg  cattcagta  gaagggagg  catctggaa  gggagtacc  gttttgtac  1080
ccaattgca  ctgcctggt  acttaagga  gggaaagtc  ttcccatca  tctttttga  1140
gatacaagt  atacatcta  tgatgatgt  ttagaagat  aagaagaca  tgtagaagc  1200
gccagagga  ccacagaaa  cagtgttta  ttgggaatg  atagaggcc  gctgtatct  1260
cagtcatca  tcagaattt  agaaaagtt  ccttcaagt  ccaaggctt  ggaatctgt  1320
actaatgaa  acgcaatta  tcctttacc  acaatcaaa  ggaaaccct  aattcattc  1380
ccttccaga  ctcctgtct  ggtaggatc  gatgaattt  acaaatgtc  cagtaatga  1440
aagttttct  atgaagaat  tagtaatgg  gcactttca  tcttgcagt  tccatatga  1500
aatggttat  atctaccat  ctacaagag  gagaggaac  aacgaagca  acagattac  1560
gtcagattc  tcgacaacc  acattacaa  aagaatatc  gcaaaaagg  tcctgttct  1620
cttttacac  ggtggaaag  aatagttgc  acgattttg  tttgtatca  agcaacaac  1680
tttattgtg  gcaggcttt  ccatcctca  cctcacagg  aaaggaagg  gtctgaaac  1740
cagtgtcaa  ctgaaaata  atatgattc  gtaagtggt  aagccaatg  cagtagctg  1800
aatgacata  aaaactctg  atatatatc  cgatatcta  ctgattttg  gccaattca  1860
tgcctggga  gtggtggct  tggagttgt  tttgaagct  aaaacaaag  agatgactg  1920
aattatgct  tcaagagga  ccgtctccc  aatagggaa  tggctcggg  aaaggtaat  1980
cgagaagtt  aagccttag  caagcttga  cacccgggc  ttgttagat  tttcaatgc  2040
tggctcgaa  caccaccag  gaagtggca  gaaaagatg  atgaaattt  gctgaaaga  2100
gaaagcaca  actggccac  cagctctcc  agcccaatg  atgcaccat  agttaaaat  2160
cgcagaatg  atcctttct  tacaaaaga  catattgaa  tcatagctc  ttcaccaca  2220
agaagcagg  ctttttcag  agggatttc  tgtgaccag  caagttcat  tgagagcca  2280
ttctcacca  tggaattct  aggaatgga  catgaggac  tcagtgagt  agtggatgc  2340
gcatacaac  tccaggaca  ttgccttac  gactgtgat  tggaagatg  gactatgga  2400
ggcaatgat  aggggcact  ctttgaact  tgtccttct  aagcttctc  ttatgtaag  2460
tcaagggag  gaacctcct  ttcaatagt  tttgaagat  ctggctgtg  taatgcttc  2520
agtaaagaa  agccgaaaa  taatcgatt  catattggc  accattgtg  taataaact  2580
actgctttc  agcccacca  tagcaaatc  tcttctgaa  ctacattgt  tatttctcc  2640
ccaagacca  ccactttaa  tttagatct  actaaaaac  ccacagaaa  actccagcc  2700
agttcacca  aggtgtatc  ttacattca  atgcagctg  gcagaaaag  aaacctcaa  2760
gactggatg  atggacgat  taccataga  gagagagag  ggagcgtgt  tctgcacat  2820
ttcctgcag  tcgcagagg  agtggagtt  cttcacagt  aaggactga  gcacaggga  2880
ctcaagcca  ccaacatat  ctttacaat  gatgatgtg  tcaaggttg  agactttgg  2940
ttagtgact  caatggacc  ggatgagga  gagcagacg  ttctgaccc  aatgccagc  3000
tatgccaga  acacaggac  agtagggac  aaactgtat  tgagcccag  gcagattca  3060
ggaaacagc  attctcata  agtggacat  ttttcttta  gcctgattc  atttgaatt  3120
ctgtatcca  tcagcactc  gatggagag  gtcaggacc  taactgatg  aagaaatct  3180
aaatttcca  cattattta  tcagaaata  ccttgtgag  acgtgatgg  tcaagacat  3240
ctctctcca  cccccatgg  acgacctga  gctataaac  tcattgaaa  tgctgtatt  3300
gaggacttg  actttccag  aaaaacagt  ctcagacag  ggtctcgct  cttgagttc  3360
tcgggaaca  aacattcaa  acagtccaa  aactcccat  gccctttgc  aagcaatta  3420
ccttaagtt  tgctagcaa  cctaatagg  gatgcagat  atagcctac  tcttagaat  3480
tgcctgtcc  aaattgcag  cttgaaaag  ttgttcttc  ctcaatttt  ttgtggact  3540
cttttttta  atcaaattt  agctggatt  gggggcata  cctaatttg  gccaactcc  3600
gagttttgc  atacttaag  aaagggcta  ctttgttct  tgttagtct  ttgaaactg  3660
ctgctggcc  agctttata  ccctcacca  ttgcctaag  aggtagcag  aatccctaa  3720
atatatata  agtgagaac  aaaatggat  tatttttat  atgcagaag  aggaaagtc  3780
ccctgtgtg  taactgtat  gttctagaa  tatgctttc  agagatatg  tgattttga  3840
actgatttc  agaaaaagc  gactccatt  ttgtccctg  cgggtaaat  aggaatctg  3900
actattttg  aggacaagt  gcacaaact  tataacggt  tatgtccgt  gttttatag  3960
cctatttgt  gcattcaat  gctttattc  ttagatggt  ctagggtgg  tttacagct  4020
tttgtactt  tacctccaa  aaagggaaa  tgaagcttt  tatgtaaat  ggttgaaag  4080
tctagtttt  ggaggaaaa  agccgtagt  agaaatgga  catatatat  acaactaac  4140
tcttcaact  tggactttt  aagcctaat  aaatcttaa  tgtcttata  gtaatcctg  4200
aggttggta  ttcccccaa  ctgattata  gtaacagtt  aatcatctc  cttgctaac  4260
tgtttttat  tttcactgt  aatatgttt  tgttttatt  ataaaaatt  tgaaatcaa  4320
ccatg  4325



<210> 1287
<211> 1115
<212> PRT
<213> Homo sapiens
<308> Q9NZJ5
<400> 1287

Met Glu Arg Ala Ile Ser Pro Gly Leu Leu Val Arg Ala Leu Leu Leu 
  1               5                  10                  15
Leu Leu Leu Leu Gly Leu Ala Ala Arg Thr Val Ala Ala Gly Arg Ala 
             20                  25                  30
Arg Gly Leu Pro Ala Pro Thr Ala Glu Ala Ala Phe Gly Leu Gly Ala 
         35                  40                  45
Ala Ala Ala Pro Thr Ser Ala Thr Arg Val Pro Ala Ala Gly Ala Val 
     50                  55                  60
Ala Ala Ala Glu Val Thr Val Glu Asp Ala Glu Ala Leu Pro Ala Ala 
 65                  70                  75                  80
Ala Gly Glu Gln Glu Pro Arg Gly Pro Glu Pro Asp Asp Glu Thr Glu 
                 85                  90                  95
Leu Arg Pro Arg Gly Arg Ser Leu Val Ile Ile Ser Thr Leu Asp Gly 
             100                105                110
Arg Ile Ala Ala Leu Asp Pro Glu Asn His Gly Lys Lys Gln Trp Asp 
         115                120                125
Leu Asp Val Gly Ser Gly Ser Leu Val Ser Ser Ser Leu Ser Lys Pro 
     130                135                140
Glu Val Phe Gly Asn Lys Met Ile Ile Pro Ser Leu Asp Gly Ala Leu 
 145                150                155                160
Phe Gln Trp Asp Arg Asp Arg Glu Ser Met Glu Thr Val Pro Phe Thr 
                 165                170                175
Val Glu Ser Leu Leu Glu Ser Ser Tyr Lys Phe Gly Asp Asp Val Val 
             180                185                190
Leu Val Gly Gly Lys Ser Leu Thr Thr Tyr Gly Leu Ser Ala Tyr Ser 
         195                200                205
Gly Lys Val Arg Tyr Ile Cys Ser Ala Leu Gly Cys Arg Gln Trp Asp 
     210                215                220
Ser Asp Glu Met Glu Gln Glu Glu Asp Ile Leu Leu Leu Gln Arg Thr 
 225                230                235                240
Gln Lys Thr Val Arg Ala Val Gly Pro Arg Ser Gly Asn Glu Lys Trp 
                 245                250                255
Asn Phe Ser Val Gly His Phe Glu Leu Arg Tyr Ile Pro Asp Met Glu 
             260                265                270
Thr Arg Ala Gly Phe Ile Glu Ser Thr Phe Lys Pro Asn Glu Asn Thr 
         275                280                285
Glu Glu Ser Lys Ile Ile Ser Asp Val Glu Glu Gln Glu Ala Ala Ile 
     290                295                300
Met Asp Ile Val Ile Lys Val Ser Val Ala Asp Trp Lys Val Met Ala 
 305                310                315                320
Phe Ser Lys Lys Gly Gly His Leu Glu Trp Glu Tyr Gln Phe Cys Thr 
                 325                330                335
Pro Ile Ala Ser Ala Trp Leu Leu Lys Asp Gly Lys Val Ile Pro Ile 
             340                345                350
Ser Leu Phe Asp Asp Thr Ser Tyr Thr Ser Asn Asp Asp Val Leu Glu 
         355                360                365
Asp Glu Glu Asp Ile Val Glu Ala Ala Arg Gly Ala Thr Glu Asn Ser 
     370                375                380
Val Tyr Leu Gly Met Tyr Arg Gly Gln Leu Tyr Leu Gln Ser Ser Val 
 385                390                395                400
Arg Ile Ser Glu Lys Phe Pro Ser Ser Pro Lys Ala Leu Glu Ser Val 
                 405                410                415
Thr Asn Glu Asn Ala Ile Ile Pro Leu Pro Thr Ile Lys Trp Lys Pro 
             420                425                430
Leu Ile His Ser Pro Ser Arg Thr Pro Val Leu Val Gly Ser Asp Glu 
         435                440                445
Phe Asp Lys Cys Leu Ser Asn Asp Lys Phe Ser His Glu Glu Tyr Ser 
     450                455                460
Asn Gly Ala Leu Ser Ile Leu Gln Tyr Pro Tyr Asp Asn Gly Tyr Tyr 
 465                470                475                480
Leu Pro Tyr Tyr Lys Arg Glu Arg Asn Lys Arg Ser Thr Gln Ile Thr 
                 485                490                495
Val Arg Phe Leu Asp Asn Pro His Tyr Asn Lys Asn Ile Arg Lys Lys 
             500                505                510
Asp Pro Val Leu Leu Leu His Trp Trp Lys Glu Ile Val Ala Thr Ile 
         515                520                525
Leu Phe Cys Ile Ile Ala Thr Thr Phe Ile Val Arg Arg Leu Phe His 
     530                535                540
Pro His Pro His Arg Gln Arg Lys Glu Ser Glu Thr Gln Cys Gln Thr 
 545                550                555                560
Glu Asn Lys Tyr Asp Ser Val Ser Gly Glu Ala Asn Asp Ser Ser Trp 
                 565                570                575
Asn Asp Ile Lys Asn Ser Gly Tyr Ile Ser Arg Tyr Leu Thr Asp Phe 
             580                585                590
Glu Pro Ile Gln Cys Leu Gly Arg Gly Gly Phe Gly Val Val Phe Glu 
         595                600                605
Ala Lys Asn Lys Val Asp Asp Cys Asn Tyr Ala Ile Lys Arg Ile Arg 
     610                615                620
Leu Pro Asn Arg Glu Leu Ala Arg Glu Lys Val Met Arg Glu Val Lys 
 625                630                635                640
Ala Leu Ala Lys Leu Glu His Pro Gly Ile Val Arg Tyr Phe Asn Ala 
                 645                650                655
Trp Leu Glu Ala Pro Pro Glu Lys Trp Gln Glu Lys Met Asp Glu Ile 
             660                665                670
Trp Leu Lys Asp Glu Ser Thr Asp Trp Pro Leu Ser Ser Pro Ser Pro 
         675                680                685
Met Asp Ala Pro Ser Val Lys Ile Arg Arg Met Asp Pro Phe Ser Thr 
     690                695                700
Lys Glu His Ile Glu Ile Ile Ala Pro Ser Pro Gln Arg Ser Arg Ser 
 705                710                715                720
Phe Ser Val Gly Ile Ser Cys Asp Gln Thr Ser Ser Ser Glu Ser Gln 
                 725                730                735
Phe Ser Pro Leu Glu Phe Ser Gly Met Asp His Glu Asp Ile Ser Glu 
             740                745                750
Ser Val Asp Ala Ala Tyr Asn Leu Gln Asp Ser Cys Leu Thr Asp Cys 
         755                760                765
Asp Val Glu Asp Gly Thr Met Asp Gly Asn Asp Glu Gly His Ser Phe 
     770                775                780
Glu Leu Cys Pro Ser Glu Ala Ser Pro Tyr Val Arg Ser Arg Glu Arg 
 785                790                795                800
Thr Ser Ser Ser Ile Val Phe Glu Asp Ser Gly Cys Asp Asn Ala Ser 
                 805                810                815
Ser Lys Glu Glu Pro Lys Thr Asn Arg Leu His Ile Gly Asn His Cys 
             820                825                830
Ala Asn Lys Leu Thr Ala Phe Lys Pro Thr Ser Ser Lys Ser Ser Ser 
         835                840                845
Glu Ala Thr Leu Ser Ile Ser Pro Pro Arg Pro Thr Thr Leu Ser Leu 
     850                855                860
Asp Leu Thr Lys Asn Thr Thr Glu Lys Leu Gln Pro Ser Ser Pro Lys 
 865                870                875                880
Val Tyr Leu Tyr Ile Gln Met Gln Leu Cys Arg Lys Glu Asn Leu Lys 
                 885                890                895
Asp Trp Met Asn Gly Arg Cys Thr Ile Glu Glu Arg Glu Arg Ser Val 
             900                905                910
Cys Leu His Ile Phe Leu Gln Ile Ala Glu Ala Val Glu Phe Leu His 
         915                920                925
Ser Lys Gly Leu Met His Arg Asp Leu Lys Pro Ser Asn Ile Phe Phe 
     930                935                940
Thr Met Asp Asp Val Val Lys Val Gly Asp Phe Gly Leu Val Thr Ala 
 945                950                955                960
Met Asp Gln Asp Glu Glu Glu Gln Thr Val Leu Thr Pro Met Pro Ala 
                 965                970                975
Tyr Ala Arg His Thr Gly Gln Val Gly Thr Lys Leu Tyr Met Ser Pro 
             980                985                990
Glu Gln Ile His Gly Asn Ser Tyr Ser His Lys Val Asp Ile Phe Ser 
         995                1000                1005
Leu Gly Leu Ile Leu Phe Glu Leu Leu Tyr Pro Phe Ser Thr Gln Met 
     1010                1015                1020
Glu Arg Val Arg Thr Leu Thr Asp Val Arg Asn Leu Lys Phe Pro Pro 
 1025                1030                1035                1040
Leu Phe Thr Gln Lys Tyr Pro Cys Glu Tyr Val Met Val Gln Asp Met 
                 1045                1050                1055
Leu Ser Pro Ser Pro Met Glu Arg Pro Glu Ala Ile Asn Ile Ile Glu 
             1060                1065                1070
Asn Ala Val Phe Glu Asp Leu Asp Phe Pro Gly Lys Thr Val Leu Arg 
         1075                1080                1085
Gln Arg Ser Arg Ser Leu Ser Ser Ser Gly Thr Lys His Ser Arg Gln 
     1090                1095                1100
Ser Asn Asn Ser His Ser Pro Leu Pro Ser Asn 
 1105                1110                1115



<210> 1288
<211> 4510
<212> DNA
<213> Rattus norvegicus
<308> AF096835
<400> 1288

gcggaaccc  cgctcaatg  gcgatgtct  tacaaggct  tcactcagg  ggcagtggc  60
gagacgtgg  cgggcagct  tgctgctgc  gcgtgaagt  gagaggcgt  ggggtccgt  120
gtgcgcgct  tcggtgctc  aaggctcct  gcggcgaga  gggccggcg  cgaccgcag  180
gtctccatg  ccgctcgtg  ggcgggccg  tgatggagc  cgccaccca  ccccgaccg  240
gcgcgctgc  gctgctgtt  ctgctgctg  gctgcgcgg  ggggatctc  gcggtcgcg  300
gcgcccgca  cttgcttgc  cccacatcg  atacggcat  tggcttggg  gcagcagcc  360
cccctactt  agccgcgcg  gtgcctgcg  tggctacgg  cgaagtgac  gtggaagac  420
ccgaggcat  gcccgctgc  tccggcgaa  aggagtcac  cgcgaccga  tccgatgac  480
acgtggaac  gcggcctcg  ggcaggtcc  tagtaatca  cagcacttt  gatggacga  540
ttgccgcac  ggatgccga  aatcatggg  aaaagcagt  ggatttgga  gtgggatct  600
gttccttgg  ttcatctag  cttagcaag  cagaggtgt  tgggaacaa  atgatcatt  660
cttccctgg  cggagacct  ttccagtgg  accgagacc  agagagcat  gaggccgtc  720
ctttcactg  ggagtccct  ctcgaatct  catacaagt  tggagatga  gttgttctg  780
ttggaggaa  gtctctgac  acatacggg  tcagtgcat  tagtggaaa  ctgaggtat  840
tctgttctg  cttgggatg  cgccgatgg  atagtgatg  aatggaaga  gaggaagac  900
tcttgcttc  gcaacgcac  cagaagact  tgcgagctg  cgggcctcg  agcggcagt  960
agaagtgga  tttcagtgt  ggccacttt  aacttcggt  tattccaga  atggaaact  1020
gagccggat  cattgaaag  acctttaaa  tgggtggaa  caaagaaga  tctaaaatc  1080
tttcagatg  ggaagaaca  gatgtggac  cagtgataa  agtttccgt  gctgattgg  1140
aggtcatgg  gtttagtaa  aagggaggc  gcctagaat  ggagtacca  ttttgtact  1200
ccattgcgt  tgcctggct  gtgagggat  gtaaagtca  ccccatcag  ctgtttgat  1260
acacaagtt  cacagccaa  gaggaagtt  tggaagatg  agaagacat  gtagaggct  1320
ctcggggag  cacagagaa  agcgtgtac  tagggatgt  cagaggcca  ctgtacctg  1380
aatcatccg  cagggtctc  gaaaagttc  ctacaaggc  gaaggcctt  gagtctgta  1440
atggagaaa  tgccattat  cctctgccg  cgatcaaat  gaagccctt  atccattct  1500
cgtctagga  tcctgtctt  gttgggtct  atgaatttg  caagtgtct  agtaatgat  1560
aatattccc  tgaagaata  agtaatggt  cgctttcaa  cctacagta  ccatatgac  1620
acggttact  tctgcctta  tacaagaga  aaaggaata  gcggagcac  cagatcacg  1680
tcaggttcc  ggacagccc  cactacagc  agaacatcc  caagaagga  cccatcctc  1740
tcctgcact  gtggaagga  atatttgga  cgatcttgc  ttgcattgt  gccacgacc  1800
ttatcgtgc  caggctttt  catcctcag  cccacaggc  acggaagga  tctgaaact  1860
agtgccaaa  tgaaagtaa  tacgactct  tgagtgctg  taacagcga  aacagctgg  1920
acgacatta  acactcagg  tacgtgtcc  gatacctaa  agattttga  ccaattcag  1980
gcatgggtc  aggcggctt  ggcgttgtc  ttgaagcta  gaacaaagt  gatgactgc  2040
attacgcca  caagaggat  cgtctccca  acagggagc  ggcacggga  aaggtaatg  2100
gggaagtca  agccttggc  aagctggag  acccaggca  cgtgaggta  ttcaatgcg  2160
ggctggaaa  accaccaga  aagtggcaa  aggagatgg  tgaaatctg  ctgaaggac  2220
aaagcacag  ctggccact  agctcccct  gcccaatgg  tgccccatc  gttaagatc  2280
ggcagatgg  tcctttctc  acaaaagaa  agattgaag  catagctcc  tctcctgaa  2340
gaagtcggt  tttctcagt  ggcatttcc  gtggccgga  aagctcatc  gagagccag  2400
tctctcccc  ggagttctc  gggacagac  gtggagaca  cagtgactc  gaggacgca  2460
cccacaacc  ccaggacag  tgcctgaca  attgcgaca  ggaagatgg  acagtggac  2520
gcgatgatg  gggacactc  tttgaactt  gtccttctg  agcttctcc  tataccagg  2580
caagggagg  aacgtcctc  tccatagtg  ttgaagact  tggctgtga  aatgcgtcc  2640
gtaaggagg  ccccagaat  aatcggctg  ataatggcc  ccattacgt  aataagcta  2700
ctgagttca  gcactccag  agcaggtct  cttccgaag  caccttgtc  acctctcct  2760
ccaggccaa  caccctaag  ttagatttc  ccaggaaca  ggtggaccg  ctccagccc  2820
gctccccca  ggtgtacct  tacatccag  tgcagctgt  caggaagga  aaccttaaa  2880
actggatga  ccggcgctg  agcatggag  acagggagc  cagagtgtg  ctgcacatc  2940
ttctgcaga  cgcagaggc  gtgcagttt  tgcacagca  gggactcat  cacagggac  3000
tcaagcctt  caacatatt  ttcacaatg  atgatgtgg  caaagttgg  gactttggg  3060
tagtgactg  aatggacca  gatgaagaa  agcagacag  actgactcc  atgccagcc  3120
atgctacac  cacgggaca  gtcgggacc  agctgtaca  gagcccaga  cagattcat  3180
gaaacaact  ctcccataa  gtggacatc  tctctttag  cttgattct  tttgaactc  3240
tttacccat  cagcactca  atggaacga  ttaggactt  aactgatgt  agaaatctc  3300
agtttccac  actgttcac  cagaaatat  cccaagagc  tatgatggt  caagacatg  3360
tttctccat  ccccatgga  cggcctgaa  ccacagaca  cattgaaaa  gctgtgttt  3420
agaacttgg  gtttcctgg  aaaacggtt  tgagacagc  gtcccgctc  ttgagttca  3480
ccggaacta  acattccag  cagcccagc  gcacattca  cccactgcc  ggcaactag  3540
ctccagctg  gcctgcggc  ctcagaggt  gcacaggac  ggcaccttg  ggaatgtgg  3600
tctccgtgg  ggcggactc  ttttatgct  tgatcaact  gacttagga  caatttttc  3660
aagtcagac  ggattatgg  cctaaccca  tttgatctt  actaaactt  aaggaaagg  3720
ctatataaa  gacaagtgg  tttgtttct  gttggtgtc  caaaactag  tggtcaagc  3780
acagaacct  cacttttca  caggaggca  aagacagcc  gaaaccatc  gaactggaa  3840
tgactttaa  gcacaaagg  gtgaaagac  ctctcacat  ggaactaca  gttctagaa  3900
cgtgctttc  agaaataca  gggtgatta  ggaagcgac  gttataaag  tgactccat  3960
tttgtccct  gtgagcatg  gacccatct  cactatttt  gaaggcgca  cacaggctg  4020
gtggccatt  atgtcagta  tgccatagt  tgcagcagt  aataacttc  ctttttagg  4080
ggtctaggg  gcacggtga  ctttttgta  ttttttatc  ccagtaatg  gaaaatgaa  4140
ctttttagg  attggtcaa  agatctgat  ggagggttt  aaaagaagt  tagtaagaa  4200
tgggtcacc  attacacct  acttattcc  ttatggagt  tttgtccta  tagaagtct  4260
ccttatgtg  aatactaca  gtcagcata  cccccaaac  gattatagg  aagtttaat  4320
atctcaact  gctaacatg  tctcatttt  cctgtaaat  tctttattt  ttatttata  4380
aaattctga  atcaatcca  ttgggttgg  ggtgtacag  atgcacata  gtgtgttaa  4440
tattatgac  tctttcaag  ctaaatgat  taataaaac  tttttaaat  ataaaaaaa  4500
aaaaaaaaaa  4510



<210> 1289
<211> 1108
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1Z1
<400> 1289

Met Glu Arg Ala Thr Gln Pro Arg Pro Arg Ala Leu Leu Leu Leu Phe 
  1               5                  10                  15
Leu Leu Leu Gly Cys Ala Ala Gly Ile Ser Ala Val Ala Arg Ala Arg 
             20                  25                  30
Ser Leu Leu Ala Pro Thr Ser Asp Thr Ala Phe Gly Leu Gly Ala Ala 
         35                  40                  45
Ala Ala Pro Thr Ser Ala Ala Arg Val Pro Ala Val Ala Thr Ala Glu 
     50                  55                  60
Val Thr Val Glu Asp Ala Glu Ala Leu Pro Ala Ala Ser Gly Glu Gln 
 65                  70                  75                  80
Glu Ser Arg Ala Thr Glu Ser Asp Asp Asp Val Glu Leu Arg Pro Arg 
                 85                  90                  95
Gly Arg Ser Leu Val Ile Ile Ser Thr Leu Asp Gly Arg Ile Ala Ala 
             100                105                110
Leu Asp Ala Glu Asn His Gly Lys Lys Gln Trp Asp Leu Asp Val Gly 
         115                120                125
Ser Gly Ser Leu Val Ser Ser Ser Leu Ser Lys Pro Glu Val Phe Gly 
     130                135                140
Asn Lys Met Ile Ile Pro Ser Leu Asp Gly Asp Leu Phe Gln Trp Asp 
 145                150                155                160
Arg Asp Arg Glu Ser Met Glu Ala Val Pro Phe Thr Val Glu Ser Leu 
                 165                170                175
Leu Glu Ser Ser Tyr Lys Phe Gly Asp Asp Val Val Leu Val Gly Gly 
             180                185                190
Lys Ser Leu Thr Thr Tyr Gly Leu Ser Ala Tyr Ser Gly Lys Leu Arg 
         195                200                205
Tyr Ile Cys Ser Ala Leu Gly Cys Arg Arg Trp Asp Ser Asp Glu Met 
     210                215                220
Glu Glu Glu Glu Asp Ile Leu Leu Leu Gln Arg Thr Gln Lys Thr Val 
 225                230                235                240
Arg Ala Val Gly Pro Arg Ser Gly Ser Glu Lys Trp Asn Phe Ser Val 
                 245                250                255
Gly His Phe Glu Leu Arg Tyr Ile Pro Asp Met Glu Thr Arg Ala Gly 
             260                265                270
Phe Ile Glu Ser Thr Phe Lys Leu Gly Gly Asn Lys Glu Asp Ser Lys 
         275                280                285
Ile Ile Ser Asp Val Glu Glu Gln Asp Val Asp Thr Val Ile Lys Val 
     290                295                300
Ser Val Ala Asp Trp Lys Val Met Ala Phe Ser Lys Lys Gly Gly Arg 
 305                310                315                320
Leu Glu Trp Glu Tyr Gln Phe Cys Thr Pro Ile Ala Ser Ala Trp Leu 
                 325                330                335
Val Arg Asp Gly Lys Val Ile Pro Ile Ser Leu Phe Asp Asp Thr Ser 
             340                345                350
Tyr Thr Ala Asn Glu Glu Val Leu Glu Asp Glu Glu Asp Ile Val Glu 
         355                360                365
Ala Ala Arg Gly Ala Thr Glu Asn Ser Val Tyr Leu Gly Met Tyr Arg 
     370                375                380
Gly Gln Leu Tyr Leu Gln Ser Ser Val Arg Val Ser Glu Lys Phe Pro 
 385                390                395                400
Thr Arg Pro Lys Ala Leu Glu Ser Val Asn Gly Glu Ser Ala Ile Ile 
                 405                410                415
Pro Leu Pro Thr Ile Lys Trp Lys Pro Leu Ile His Ser Pro Ser Arg 
             420                425                430
Thr Pro Val Leu Val Gly Ser Asp Glu Phe Asp Lys Cys Leu Ser Asn 
         435                440                445
Asp Lys Tyr Ser His Glu Glu Tyr Ser Asn Gly Ala Leu Ser Ile Leu 
     450                455                460
Gln Tyr Pro Tyr Asp Asn Gly Tyr Tyr Leu Pro Tyr Tyr Lys Arg Glu 
 465                470                475                480
Arg Asn Lys Arg Ser Thr Gln Ile Thr Val Arg Phe Leu Asp Ser Pro 
                 485                490                495
His Tyr Ser Lys Asn Ile Arg Lys Lys Asp Pro Ile Leu Leu Leu His 
             500                505                510
Trp Trp Lys Glu Ile Phe Gly Thr Ile Leu Leu Cys Ile Val Ala Thr 
         515                520                525
Thr Phe Ile Val Arg Arg Leu Phe His Pro Gln Pro His Arg Gln Arg 
     530                535                540
Lys Glu Ser Glu Thr Gln Cys Gln Thr Glu Ser Lys Tyr Asp Ser Val 
 545                550                555                560
Ser Ala Asp Asn Ser Asp Asn Ser Trp Asn Asp Ile Lys His Ser Gly 
                 565                570                575
Tyr Val Ser Arg Tyr Leu Thr Asp Phe Glu Pro Ile Gln Cys Met Gly 
             580                585                590
Arg Gly Gly Phe Gly Val Val Phe Glu Ala Lys Asn Lys Val Asp Asp 
         595                600                605
Cys Asn Tyr Ala Ile Lys Arg Ile Arg Leu Pro Asn Arg Glu Leu Ala 
     610                615                620
Arg Glu Lys Val Met Arg Glu Val Lys Ala Leu Ala Lys Leu Glu His 
 625                630                635                640
Pro Gly Ile Val Arg Tyr Phe Asn Ala Trp Leu Glu Thr Pro Pro Glu 
                 645                650                655
Lys Trp Gln Glu Glu Met Asp Glu Ile Trp Leu Lys Asp Glu Ser Thr 
             660                665                670
Asp Trp Pro Leu Ser Ser Pro Ser Pro Met Asp Ala Pro Ser Val Lys 
         675                680                685
Ile Arg Gln Met Asp Pro Phe Ser Thr Lys Glu Gln Ile Glu Val Ile 
     690                695                700
Ala Pro Ser Pro Glu Arg Ser Arg Ser Phe Ser Val Gly Ile Ser Cys 
 705                710                715                720
Gly Arg Thr Ser Ser Ser Glu Ser Gln Phe Ser Pro Leu Glu Phe Ser 
                 725                730                735
Gly Thr Asp Cys Gly Asp Asn Ser Asp Ser Glu Asp Ala Ala His Asn 
             740                745                750
Leu Gln Asp Ser Cys Leu Thr Asp Cys Asp Met Glu Asp Gly Thr Val 
         755                760                765
Asp Gly Asp Asp Glu Gly His Ser Phe Glu Leu Cys Pro Ser Glu Ala 
     770                775                780
Ser Pro Tyr Thr Arg Ser Arg Glu Gly Thr Ser Ser Ser Ile Val Phe 
 785                790                795                800
Glu Asp Ser Gly Cys Asp Asn Ala Ser Ser Lys Glu Asp Pro Arg Met 
                 805                810                815
Asn Arg Leu His Asn Gly His His Tyr Val Asn Lys Leu Thr Glu Phe 
             820                825                830
Lys His Ser Ser Ser Arg Ser Ser Ser Glu Ala Thr Leu Ser Thr Ser 
         835                840                845
Pro Thr Arg Pro Thr Thr Leu Ser Leu Asp Phe Thr Arg Asn Thr Val 
     850                855                860
Asp Arg Leu Gln Pro Ser Ser Pro Lys Val Tyr Leu Tyr Ile Gln Met 
 865                870                875                880
Gln Leu Cys Arg Lys Glu Asn Leu Lys Asp Trp Met Asn Arg Arg Cys 
                 885                890                895
Ser Met Glu Asp Arg Glu His Arg Val Cys Leu His Ile Phe Leu Gln 
             900                905                910
Ile Ala Glu Ala Val Gln Phe Leu His Ser Lys Gly Leu Met His Arg 
         915                920                925
Asp Leu Lys Pro Ser Asn Ile Phe Phe Thr Met Asp Asp Val Val Lys 
     930                935                940
Val Gly Asp Phe Gly Leu Val Thr Ala Met Asp Gln Asp Glu Glu Glu 
 945                950                955                960
Gln Thr Val Leu Thr Pro Met Pro Ala Tyr Ala Thr His Thr Gly Gln 
                 965                970                975
Val Gly Thr Lys Leu Tyr Met Ser Pro Glu Gln Ile His Gly Asn Asn 
             980                985                990
Tyr Ser His Lys Val Asp Ile Phe Ser Leu Gly Leu Ile Leu Phe Glu 
         995                1000                1005
Leu Leu Tyr Pro Phe Ser Thr Gln Met Glu Arg Val Arg Thr Leu Thr 
     1010                1015                1020
Asp Val Arg Asn Leu Lys Phe Pro Pro Leu Phe Thr Gln Lys Tyr Pro 
 1025                1030                1035                1040
Gln Glu His Met Met Val Gln Asp Met Leu Ser Pro Ser Pro Met Glu 
                 1045                1050                1055
Arg Pro Glu Ala Thr Asp Ile Ile Glu Asn Ala Val Phe Glu Asn Leu 
             1060                1065                1070
Glu Phe Pro Gly Lys Thr Val Leu Arg Gln Arg Ser Arg Ser Leu Ser 
         1075                1080                1085
Ser Ser Gly Thr Lys His Ser Arg Gln Pro Ser Ser Thr Phe Ser Pro 
     1090                1095                1100
Leu Pro Gly Asn 
 1105



<210> 1290
<211> 4325
<212> DNA
<213> Homo sapiens
<308> AF110146
<400> 1290

ggagctcca  gcggcggga  aggcaggcg  cagtggctg  gcctccatg  ctgcgcgcg  60
ggcgggacg  tgatggagc  cgccatcag  ccggggctg  tggtacggg  gctgctgct  120
ctgctgctg  tggggctcg  ggcaaggac  gtggccgcg  ggcgcgccc  tggcctccc  180
gcgccgacg  cggaggcgg  gttcggcct  ggggcggcc  ctgctccca  ctcagcgac  240
cgagtaccg  cggcgggcg  cgtggctgc  gccgaggtg  ctgtggagg  cgctgaggc  300
ctgccggca  ccgcgggag  gcaggagcc  cggggtccg  aaccagacg  tgagacaga  360
ttgcgaccg  gcggcaggt  attagtaat  atcagcact  tagatggga  aattgctgc  420
ttggatcct  aaaatcatg  taaaaagca  tgggatttg  atgtgggat  cggttcctt  480
gtgtcatcc  gccttagca  accagaggt  tttgggaat  agatgatca  tccttccct  540
gatggagcc  tcttccagt  ggaccgaga  cgtgaaagc  tggaaacag  tcctttcac  600
gttgaatca  ttcttgaat  ttcttataa  tttggagat  atgttgttt  ggttggagg  660
aaatctctg  ctacatatg  actcagtgc  tatagtgga  aggtgaggt  tatctgttc  720
gctctgggt  gtcgccaat  ggatagtga  gaaatggaa  aagaggaag  catcctgct  780
ctacagcgt  cccaaaaaa  tgttagagc  gtcggacct  gcagtggca  tgagaagtg  840
aatttcagt  ttggccact  tgaacttcg  tatattcca  acatggaaa  gagagccgg  900
tttattgaa  gcaccttta  gcccaatga  aacacagaa  agtctaaaa  tatttcaga  960
gtggaagaa  aggaagctg  cataatgga  atagtgata  aggtttcgg  tgctgactg  1020
aaagttatg  cattcagta  gaagggagg  catctggaa  gggagtacc  gttttgtac  1080
ccaattgca  ctgcctggt  acttaagga  gggaaagtc  ttcccatca  tctttttga  1140
gatacaagt  atacatcta  tgatgatgt  ttagaagat  aagaagaca  tgtagaagc  1200
gccagagga  ccacagaaa  cagtgttta  ttgggaatg  atagaggcc  gctgtatct  1260
cagtcatca  tcagaattt  agaaaagtt  ccttcaagt  ccaaggctt  ggaatctgt  1320
actaatgaa  acgcaatta  tcctttacc  acaatcaaa  ggaaaccct  aattcattc  1380
ccttccaga  ctcctgtct  ggtaggatc  gatgaattt  acaaatgtc  cagtaatga  1440
aagttttct  atgaagaat  tagtaatgg  gcactttca  tcttgcagt  tccatatga  1500
aatggttat  atctaccat  ctacaagag  gagaggaac  aacgaagca  acagattac  1560
gtcagattc  tcgacaacc  acattacaa  aagaatatc  gcaaaaagg  tcctgttct  1620
cttttacac  ggtggaaag  aatagttgc  acgattttg  tttgtatca  agcaacaac  1680
tttattgtg  gcaggcttt  ccatcctca  cctcacagg  aaaggaagg  gtctgaaac  1740
cagtgtcaa  ctgaaaata  atatgattc  gtaagtggt  aagccaatg  cagtagctg  1800
aatgacata  aaaactctg  atatatatc  cgatatcta  ctgattttg  gccaattca  1860
tgcctggga  gtggtggct  tggagttgt  tttgaagct  aaaacaaag  agatgactg  1920
aattatgct  tcaagagga  ccgtctccc  aatagggaa  tggctcggg  aaaggtaat  1980
cgagaagtt  aagccttag  caagcttga  cacccgggc  ttgttagat  tttcaatgc  2040
tggctcgaa  caccaccag  gaagtggca  gaaaagatg  atgaaattt  gctgaaaga  2100
gaaagcaca  actggccac  cagctctcc  agcccaatg  atgcaccat  agttaaaat  2160
cgcagaatg  atcctttct  tacaaaaga  catattgaa  tcatagctc  ttcaccaca  2220
agaagcagg  ctttttcag  agggatttc  tgtgaccag  caagttcat  tgagagcca  2280
ttctcacca  tggaattct  aggaatgga  catgaggac  tcagtgagt  agtggatgc  2340
gcatacaac  tccaggaca  ttgccttac  gactgtgat  tggaagatg  gactatgga  2400
ggcaatgat  aggggcact  ctttgaact  tgtccttct  aagcttctc  ttatgtaag  2460
tcaagggag  gaacctcct  ttcaatagt  tttgaagat  ctggctgtg  taatgcttc  2520
agtaaagaa  agccgaaaa  taatcgatt  catattggc  accattgtg  taataaact  2580
actgctttc  agcccacca  tagcaaatc  tcttctgaa  ctacattgt  tatttctcc  2640
ccaagacca  ccactttaa  tttagatct  actaaaaac  ccacagaaa  actccagcc  2700
agttcacca  aggtgtatc  ttacattca  atgcagctg  gcagaaaag  aaacctcaa  2760
gactggatg  atggacgat  taccataga  gagagagag  ggagcgtgt  tctgcacat  2820
ttcctgcag  tcgcagagg  agtggagtt  cttcacagt  aaggactga  gcacaggga  2880
ctcaagcca  ccaacatat  ctttacaat  gatgatgtg  tcaaggttg  agactttgg  2940
ttagtgact  caatggacc  ggatgagga  gagcagacg  ttctgaccc  aatgccagc  3000
tatgccaga  acacaggac  agtagggac  aaactgtat  tgagcccag  gcagattca  3060
ggaaacagc  attctcata  agtggacat  ttttcttta  gcctgattc  atttgaatt  3120
ctgtatcca  tcagcactc  gatggagag  gtcaggacc  taactgatg  aagaaatct  3180
aaatttcca  cattattta  tcagaaata  ccttgtgag  acgtgatgg  tcaagacat  3240
ctctctcca  cccccatgg  acgacctga  gctataaac  tcattgaaa  tgctgtatt  3300
gaggacttg  actttccag  aaaaacagt  ctcagacag  ggtctcgct  cttgagttc  3360
tcgggaaca  aacattcaa  acagtccaa  aactcccat  gccctttgc  aagcaatta  3420
ccttaagtt  tgctagcaa  cctaatagg  gatgcagat  atagcctac  tcttagaat  3480
tgcctgtcc  aaattgcag  cttgaaaag  ttgttcttc  ctcaatttt  ttgtggact  3540
cttttttta  atcaaattt  agctggatt  gggggcata  cctaatttg  gccaactcc  3600
gagttttgc  atacttaag  aaagggcta  ctttgttct  tgttagtct  ttgaaactg  3660
ctgctggcc  agctttata  ccctcacca  ttgcctaag  aggtagcag  aatccctaa  3720
atatatata  agtgagaac  aaaatggat  tatttttat  atgcagaag  aggaaagtc  3780
ccctgtgtg  taactgtat  gttctagaa  tatgctttc  agagatatg  tgattttga  3840
actgatttc  agaaaaagc  gactccatt  ttgtccctg  cgggtaaat  aggaatctg  3900
actattttg  aggacaagt  gcacaaact  tataacggt  tatgtccgt  gttttatag  3960
cctatttgt  gcattcaat  gctttattc  ttagatggt  ctagggtgg  tttacagct  4020
tttgtactt  tacctccaa  aaagggaaa  tgaagcttt  tatgtaaat  ggttgaaag  4080
tctagtttt  ggaggaaaa  agccgtagt  agaaatgga  catatatat  acaactaac  4140
tcttcaact  tggactttt  aagcctaat  aaatcttaa  tgtcttata  gtaatcctg  4200
aggttggta  ttcccccaa  ctgattata  gtaacagtt  aatcatctc  cttgctaac  4260
tgtttttat  tttcactgt  aatatgttt  tgttttatt  ataaaaatt  tgaaatcaa  4320
ccatg  4325



<210> 1291
<211> 1115
<212> PRT
<213> Homo sapiens
<308> Q9NZJ5
<400> 1291

Met Glu Arg Ala Ile Ser Pro Gly Leu Leu Val Arg Ala Leu Leu Leu 
  1               5                  10                  15
Leu Leu Leu Leu Gly Leu Ala Ala Arg Thr Val Ala Ala Gly Arg Ala 
             20                  25                  30
Arg Gly Leu Pro Ala Pro Thr Ala Glu Ala Ala Phe Gly Leu Gly Ala 
         35                  40                  45
Ala Ala Ala Pro Thr Ser Ala Thr Arg Val Pro Ala Ala Gly Ala Val 
     50                  55                  60
Ala Ala Ala Glu Val Thr Val Glu Asp Ala Glu Ala Leu Pro Ala Ala 
 65                  70                  75                  80
Ala Gly Glu Gln Glu Pro Arg Gly Pro Glu Pro Asp Asp Glu Thr Glu 
                 85                  90                  95
Leu Arg Pro Arg Gly Arg Ser Leu Val Ile Ile Ser Thr Leu Asp Gly 
             100                105                110
Arg Ile Ala Ala Leu Asp Pro Glu Asn His Gly Lys Lys Gln Trp Asp 
         115                120                125
Leu Asp Val Gly Ser Gly Ser Leu Val Ser Ser Ser Leu Ser Lys Pro 
     130                135                140
Glu Val Phe Gly Asn Lys Met Ile Ile Pro Ser Leu Asp Gly Ala Leu 
 145                150                155                160
Phe Gln Trp Asp Arg Asp Arg Glu Ser Met Glu Thr Val Pro Phe Thr 
                 165                170                175
Val Glu Ser Leu Leu Glu Ser Ser Tyr Lys Phe Gly Asp Asp Val Val 
             180                185                190
Leu Val Gly Gly Lys Ser Leu Thr Thr Tyr Gly Leu Ser Ala Tyr Ser 
         195                200                205
Gly Lys Val Arg Tyr Ile Cys Ser Ala Leu Gly Cys Arg Gln Trp Asp 
     210                215                220
Ser Asp Glu Met Glu Gln Glu Glu Asp Ile Leu Leu Leu Gln Arg Thr 
 225                230                235                240
Gln Lys Thr Val Arg Ala Val Gly Pro Arg Ser Gly Asn Glu Lys Trp 
                 245                250                255
Asn Phe Ser Val Gly His Phe Glu Leu Arg Tyr Ile Pro Asp Met Glu 
             260                265                270
Thr Arg Ala Gly Phe Ile Glu Ser Thr Phe Lys Pro Asn Glu Asn Thr 
         275                280                285
Glu Glu Ser Lys Ile Ile Ser Asp Val Glu Glu Gln Glu Ala Ala Ile 
     290                295                300
Met Asp Ile Val Ile Lys Val Ser Val Ala Asp Trp Lys Val Met Ala 
 305                310                315                320
Phe Ser Lys Lys Gly Gly His Leu Glu Trp Glu Tyr Gln Phe Cys Thr 
                 325                330                335
Pro Ile Ala Ser Ala Trp Leu Leu Lys Asp Gly Lys Val Ile Pro Ile 
             340                345                350
Ser Leu Phe Asp Asp Thr Ser Tyr Thr Ser Asn Asp Asp Val Leu Glu 
         355                360                365
Asp Glu Glu Asp Ile Val Glu Ala Ala Arg Gly Ala Thr Glu Asn Ser 
     370                375                380
Val Tyr Leu Gly Met Tyr Arg Gly Gln Leu Tyr Leu Gln Ser Ser Val 
 385                390                395                400
Arg Ile Ser Glu Lys Phe Pro Ser Ser Pro Lys Ala Leu Glu Ser Val 
                 405                410                415
Thr Asn Glu Asn Ala Ile Ile Pro Leu Pro Thr Ile Lys Trp Lys Pro 
             420                425                430
Leu Ile His Ser Pro Ser Arg Thr Pro Val Leu Val Gly Ser Asp Glu 
         435                440                445
Phe Asp Lys Cys Leu Ser Asn Asp Lys Phe Ser His Glu Glu Tyr Ser 
     450                455                460
Asn Gly Ala Leu Ser Ile Leu Gln Tyr Pro Tyr Asp Asn Gly Tyr Tyr 
 465                470                475                480
Leu Pro Tyr Tyr Lys Arg Glu Arg Asn Lys Arg Ser Thr Gln Ile Thr 
                 485                490                495
Val Arg Phe Leu Asp Asn Pro His Tyr Asn Lys Asn Ile Arg Lys Lys 
             500                505                510
Asp Pro Val Leu Leu Leu His Trp Trp Lys Glu Ile Val Ala Thr Ile 
         515                520                525
Leu Phe Cys Ile Ile Ala Thr Thr Phe Ile Val Arg Arg Leu Phe His 
     530                535                540
Pro His Pro His Arg Gln Arg Lys Glu Ser Glu Thr Gln Cys Gln Thr 
 545                550                555                560
Glu Asn Lys Tyr Asp Ser Val Ser Gly Glu Ala Asn Asp Ser Ser Trp 
                 565                570                575
Asn Asp Ile Lys Asn Ser Gly Tyr Ile Ser Arg Tyr Leu Thr Asp Phe 
             580                585                590
Glu Pro Ile Gln Cys Leu Gly Arg Gly Gly Phe Gly Val Val Phe Glu 
         595                600                605
Ala Lys Asn Lys Val Asp Asp Cys Asn Tyr Ala Ile Lys Arg Ile Arg 
     610                615                620
Leu Pro Asn Arg Glu Leu Ala Arg Glu Lys Val Met Arg Glu Val Lys 
 625                630                635                640
Ala Leu Ala Lys Leu Glu His Pro Gly Ile Val Arg Tyr Phe Asn Ala 
                 645                650                655
Trp Leu Glu Ala Pro Pro Glu Lys Trp Gln Glu Lys Met Asp Glu Ile 
             660                665                670
Trp Leu Lys Asp Glu Ser Thr Asp Trp Pro Leu Ser Ser Pro Ser Pro 
         675                680                685
Met Asp Ala Pro Ser Val Lys Ile Arg Arg Met Asp Pro Phe Ser Thr 
     690                695                700
Lys Glu His Ile Glu Ile Ile Ala Pro Ser Pro Gln Arg Ser Arg Ser 
 705                710                715                720
Phe Ser Val Gly Ile Ser Cys Asp Gln Thr Ser Ser Ser Glu Ser Gln 
                 725                730                735
Phe Ser Pro Leu Glu Phe Ser Gly Met Asp His Glu Asp Ile Ser Glu 
             740                745                750
Ser Val Asp Ala Ala Tyr Asn Leu Gln Asp Ser Cys Leu Thr Asp Cys 
         755                760                765
Asp Val Glu Asp Gly Thr Met Asp Gly Asn Asp Glu Gly His Ser Phe 
     770                775                780
Glu Leu Cys Pro Ser Glu Ala Ser Pro Tyr Val Arg Ser Arg Glu Arg 
 785                790                795                800
Thr Ser Ser Ser Ile Val Phe Glu Asp Ser Gly Cys Asp Asn Ala Ser 
                 805                810                815
Ser Lys Glu Glu Pro Lys Thr Asn Arg Leu His Ile Gly Asn His Cys 
             820                825                830
Ala Asn Lys Leu Thr Ala Phe Lys Pro Thr Ser Ser Lys Ser Ser Ser 
         835                840                845
Glu Ala Thr Leu Ser Ile Ser Pro Pro Arg Pro Thr Thr Leu Ser Leu 
     850                855                860
Asp Leu Thr Lys Asn Thr Thr Glu Lys Leu Gln Pro Ser Ser Pro Lys 
 865                870                875                880
Val Tyr Leu Tyr Ile Gln Met Gln Leu Cys Arg Lys Glu Asn Leu Lys 
                 885                890                895
Asp Trp Met Asn Gly Arg Cys Thr Ile Glu Glu Arg Glu Arg Ser Val 
             900                905                910
Cys Leu His Ile Phe Leu Gln Ile Ala Glu Ala Val Glu Phe Leu His 
         915                920                925
Ser Lys Gly Leu Met His Arg Asp Leu Lys Pro Ser Asn Ile Phe Phe 
     930                935                940
Thr Met Asp Asp Val Val Lys Val Gly Asp Phe Gly Leu Val Thr Ala 
 945                950                955                960
Met Asp Gln Asp Glu Glu Glu Gln Thr Val Leu Thr Pro Met Pro Ala 
                 965                970                975
Tyr Ala Arg His Thr Gly Gln Val Gly Thr Lys Leu Tyr Met Ser Pro 
             980                985                990
Glu Gln Ile His Gly Asn Ser Tyr Ser His Lys Val Asp Ile Phe Ser 
         995                1000                1005
Leu Gly Leu Ile Leu Phe Glu Leu Leu Tyr Pro Phe Ser Thr Gln Met 
     1010                1015                1020
Glu Arg Val Arg Thr Leu Thr Asp Val Arg Asn Leu Lys Phe Pro Pro 
 1025                1030                1035                1040
Leu Phe Thr Gln Lys Tyr Pro Cys Glu Tyr Val Met Val Gln Asp Met 
                 1045                1050                1055
Leu Ser Pro Ser Pro Met Glu Arg Pro Glu Ala Ile Asn Ile Ile Glu 
             1060                1065                1070
Asn Ala Val Phe Glu Asp Leu Asp Phe Pro Gly Lys Thr Val Leu Arg 
         1075                1080                1085
Gln Arg Ser Arg Ser Leu Ser Ser Ser Gly Thr Lys His Ser Arg Gln 
     1090                1095                1100
Ser Asn Asn Ser His Ser Pro Leu Pro Ser Asn 
 1105                1110                1115



<210> 1292
<211> 3036
<212> DNA
<213> Rattus norvegicus
<308> AF097593
<400> 1292

ccgcctccg  ctcctcgct  ggcccctct  cgcctcatg  gccggatag  gggagggcc  60
cggaccctg  tgccgcttc  ggcggcctt  cttcaggca  ctctggagg  ttctggtga  120
cttgcatta  gcaagactg  atttcctga  gatgtttac  gcgcagtct  accgaagac  180
gtgcacgaa  gccagcctc  tctcaatgt  aaattcagc  actgcaata  aaaaaggaa  240
gttcagtat  aaagcagtg  accagcaga  tttaaggtg  atgaggacg  cacagtgta  300
gctgtgaga  gcttccctc  ctctgcaga  caggcaaag  tcctgatat  tgcccaaga  360
aaagaaacc  aggaaaagt  gcaggtagc  gttaacctg  gcctggagc  cagcctgac  420
gaggagccg  tgaaggaac  acatgaaat  gaagaaata  tattcccta  acaactcgc  480
aagcacagc  gagctctac  aaggcagaa  agagactgg  tcatccctc  gatcaactt  540
ccagaaaac  ccagaggac  ctttccgca  gagcttgtc  gaatcaggt  tgatagaga  600
aagaaccta  ctctgagat  cagtgtcac  gggccagga  ctgaccagc  tccaacggg  660
atcttcatc  tcaacccca  ctctggaca  ctgtcagtc  caaagcctc  ggacagaga  720
ctgatagcc  ggtttcacc  gagggcaca  gcagttgac  tcaatggca  tcaagtgga  780
aaccccatt  acatcgtca  caatgtcat  gacatgaat  ataacagac  tgagtttct  840
caccaggtt  ggaatgggt  tgttccaga  ggatcaaag  ctgggacgt  tgtgatgac  900
gtcactgcc  ttgatgcag  tgacccaaa  gccctgaat  ggatgctga  gtacaggat  960
ctctcccag  cacccagca  cccttctcc  aacatgttt  caatcaaca  cgagaccgg  1020
gacatcatc  ctgtggcag  tggtctgga  cgagagaaa  tgcaacagt  tacgttaat  1080
attcaagcc  ctgacatgg  aggcaatcc  acttacggc  tttcaaaca  agccacagc  1140
gtcatcaca  tgacagatg  caatgacaa  cctccagag  ttactgcca  gactttcta  1200
ggagaagtc  ctgagaaca  agtggatgt  attgtagcc  acctgactg  caccgacaa  1260
gaccagccc  acacaccag  ctggaatgc  gcatacaga  tcagtggtg  agaccccac  1320
ggaaggttc  ccatcctga  agaccccaa  agcaatgat  ggctagtca  agtggtaaa  1380
ccaattgac  ttgaaacga  taggatgtt  gtccttact  ttgctgcag  aaaccaagt  1440
ccattagct  aggggatcc  gcacccacc  cagtcgaca  ccacggtgt  tgtgacagt  1500
attgatgtc  atgaaaatc  ttattttgc  ccaaatcct  aaatcattc  ccaagagga  1560
ggcctccac  caggtacca  gctgaccac  ctcactgct  aggaccccg  tcgatatat  1620
caacagaat  tcagataca  aaagttatc  gaccctgcc  actggctga  aatagaccc  1680
gtgaacggg  agatcacca  tatcgctgt  ctggacaga  agtcgccaa  tgtcaaaaa  1740
aacatctat  atgctacct  ccttgcttc  gacaatgga  tccctccta  gagtggaac  1800
ggaacgctg  aaatctatt  acttgatat  aatgacaac  cccctcagg  gttacctca  1860
gaggccgag  cttgtgaaa  tccagaacc  aattcaatt  acatcacag  gcttgatta  1920
gacatagac  ccaatgcag  gccctttgc  tttgacctt  ccttatccc  agcgaccat  1980
aaaagaaac  ggaccatca  ccggcttaa  ggtgatttt  ctcagctca  tttaaagat  2040
aagtttttg  aagctggca  ctatgaagt  cccatcgtt  tcacagatt  agggaatcc  2100
cccaagtcc  atatttcca  cctgcgtgt  aaagtttgc  aatgtgact  caatggaga  2160
tgcaccgac  tagacagga  cgtgggtgc  gggcttggc  cgggcacca  catcgcgat  2220
cttctgtgt  tcatcatcc  gctgatcct  gtcctcatg  tcgtggtat  gatgaaacg  2280
cgggataaa  agcgccagg  caagcagct  ttaatagac  cagaagatg  tgtaagaga  2340
aacatattg  aatatgatg  agaaggtgg  ggagaggaa  accaggact  tgacttgag  2400
cagctccag  aaccagata  cgtggagcc  gatgccatc  aacctgtgg  aatcagacg  2460
ctagacgag  ggcctatcc  cgctgagcc  cagtatcca  tccgatccg  agccccaca  2520
cctggggat  ttggggact  cattaatga  ggccttaaa  ctgctgaca  tgaccccac  2580
gcgccacca  atgactccc  cttagtctt  gactatgag  gcagcggct  cacggctgg  2640
tccttgagc  ctctcaact  ctccagcag  ggcggggac  aggactatg  ctacctgaa  2700
gactgggga  cccgcttca  gaagctggc  gacatgtat  gtggtggtg  tgactgaac  2760
gcaggacgg  cttggcttt  ggacacgta  gaacagttt  acctgatat  cccaaaaag  2820
atacagaag  taggcttta  ctctgtagt  cactagcac  gtgcttgct  gaggctttg  2880
cgtaggctg  gaaccagtt  gggctccca  ggaatatca  tgatccgat  ctgtctgga  2940
aacaccgag  tcagctaca  ttgaatttt  cagtacaga  gcactggga  tttatgtgc  3000
tttttgtac  tttttcaga  tggaattag  tttctg  3036



<210> 1293
<211> 906
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1Y3
<400> 1293

Met Cys Arg Ile Ala Gly Gly Pro Arg Thr Leu Leu Pro Leu Leu Ala 
  1               5                  10                  15
Ala Leu Leu Gln Ala Ser Leu Glu Ala Ser Gly Glu Leu Ala Leu Cys 
             20                  25                  30
Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Pro Lys Thr 
         35                  40                  45
Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
     50                  55                  60
Arg Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
 65                  70                  75                  80
Val Asp Glu Asp Gly Thr Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                 85                  90                  95
Ala Glu Gln Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
             100                105                110
Glu Lys Trp Gln Val Ala Val Asn Leu Ser Leu Glu Pro Ser Leu Thr 
         115                120                125
Glu Glu Pro Met Lys Glu Pro His Glu Ile Glu Glu Ile Val Phe Pro 
     130                135                140
Arg Gln Leu Ala Lys His Ser Gly Ala Leu Gln Arg Gln Lys Arg Asp 
 145                150                155                160
Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                 165                170                175
Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
             180                185                190
Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
         195                200                205
Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
     210                215                220
Leu Asp Arg Glu Leu Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
 225                230                235                240
Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                 245                250                255
Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
             260                265                270
Asn Gly Ser Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
         275                280                285
Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
     290                295                300
Arg Tyr Arg Ile Leu Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
 305                310                315                320
Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                 325                330                335
Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
             340                345                350
Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
         355                360                365
Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
     370                375                380
Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Val Ile Val 
 385                390                395                400
Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                 405                410                415
Asn Ala Ala Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
             420                425                430
Ile Leu Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
         435                440                445
Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
     450                455                460
Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
 465                470                475                480
Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                 485                490                495
Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
             500                505                510
Gly Thr Met Leu Thr Thr Leu Thr Ala Gln Asp Pro Asp Arg Tyr Met 
         515                520                525
Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
     530                535                540
Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
 545                550                555                560
Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                 565                570                575
Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
             580                585                590
Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
         595                600                605
Glu Ala Glu Thr Cys Glu Thr Pro Glu Pro Asn Ser Ile Asn Ile Thr 
     610                615                620
Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
 625                630                635                640
Leu Pro Leu Ser Pro Ala Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg 
                 645                650                655
Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
             660                665                670
Ala Gly Ile Tyr Glu Val Pro Ile Val Ile Thr Asp Ser Gly Asn Pro 
         675                680                685
Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
     690                695                700
Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
 705                710                715                720
Gly Thr Gly Thr Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                 725                730                735
Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
             740                745                750
Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
         755                760                765
Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
     770                775                780
Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
 785                790                795                800
Ile Lys Pro Val Gly Ile Arg Arg Leu Asp Glu Arg Pro Ile His Ala 
                 805                810                815
Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
             820                825                830
Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
         835                840                845
Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
     850                855                860
Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
 865                870                875                880
Asp Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                 885                890                895
Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
             900                905



<210> 1294
<211> 4122
<212> DNA
<213> Homo sapiens
<308> NM_001792
<400> 1294

tttgtcatc  gctcgctct  cattggcgg  gagcggaga  cagcgaaga  gggggtggg  60
aggggaggg  aagggaagg  ggtggaaac  gcctggagc  gtttctccg  gccgctgtt  120
gtgctgccg  tgcctcctc  tcctccgcc  ccgccgccg  cgccgccgc  tcctccggc  180
cttcgctcg  cccctctcc  cctccatgt  ccggatagc  ggagcgctg  ggaccctgc  240
gccgctgct  gcggccctg  ttcaggcgt  tgtagaggc  tctggtgaa  tcgcattat  300
caagactgg  tttcctgaa  atgtttaca  tgcagtctt  tcgaaggat  tgcatgaag  360
acagcctct  ctcaatgtg  agtttagca  ctgcaatgg  aaaagaaaa  tacaatatg  420
gagcagtga  cctgcagat  ttaaggtgg  tgaagatgg  atggtgtat  ccgtgagaa  480
ctttccact  tcttctgag  atgccaagt  cctgatata  gcccaagac  aagagaccc  540
ggaaaagtg  caagtggca  taaaattga  cctgaagcc  accttaact  aggagtcag  600
gaaggagtc  gcagaagtt  aagaaatag  gttcccaag  caattcagt  agcacagtg  660
ccacctaca  aggcagaag  gagactggg  catccctcc  atcaacttg  cagaaaact  720
caggggacc  tttcctcaa  agcttgtca  gatcaggtc  gatagagat  aaaaccttt  780
actgcggta  agtgtaact  ggccaggag  tgaccagcc  ccaactggt  tcttcatta  840
caaccccat  tcgggtcag  tgtcggtga  aaagcccct  gatcgcgag  agatagccc  900
gtttcattt  agggcacat  cagtagata  taatggaaa  caagtggag  accccattg  960
cattgtcat  aatgttatt  acatgaatg  caacagacc  gagttctta  accaggttt  1020
gaatgggac  gttcctgag  gatcaaagc  tggaacata  gtgatgacc  taacagcaa  1080
tgatgctga  gatcccaat  ccctcaatg  gatgttgag  tacagaatc  tgtctcagg  1140
tccaagcac  ccttcaccc  acatgttta  aatcaacaa  gagactggt  acatcatca  1200
agtggcagc  ggacttgat  gagaaaaag  gcaacagta  acgttaata  ttcaagcta  1260
agacatgga  ggcaatccc  catatggcc  ttcaaacac  gccacggcc  tcatcacag  1320
gacagatgt  aatgacaat  ctccagagt  tactgccat  acgttttat  gtgaagttc  1380
tgagaacag  gtagacatc  tagtagcta  tctaactgt  accgataag  atcaacccc  1440
tacaccagc  tggaacgca  tgtacagaa  cagtggcgg  gatcctact  gacggttcg  1500
catccagac  gacccaaac  gcaacgacg  gttagtcac  gtggtcaaa  caatcgact  1560
tgaaacaaa  aggatgttt  tccttactg  tgctgcaga  aatcaagtg  cattagcca  1620
gggaattca  cacccgcct  agtcaactg  aaccgtgtc  gttacagtt  ttgacgtaa  1680
tgaaaaccc  tattttgcc  ccaatccta  gatcattcg  caagaagaa  ggcttcatg  1740
cggtaccat  ttgacaaca  tcactgctc  ggacccaga  cgatatatg  agcaaaata  1800
tagatacac  aaattatct  atcctgcca  ttggctaaa  atagatcct  tgaatggac  1860
aataactac  attgctgtt  tggaccgag  atcaccaaa  gtgaaaaac  atatatata  1920
tgctacttt  cttgcttct  acaatggaa  tcctcctat  agtggaaca  gaacgctgc  1980
gatctattt  cttgatatt  atgacaatg  ccctcaagt  ttacctcaa  aggcagaga  2040
ttgcgaaac  ccagacccc  attcaatta  tattacagc  cttgattat  acattgatc  2100
aaatgctgg  ccatttgct  ttgatcttc  tttatctcc  gtgactatt  agagaaatt  2160
gaccatcac  cggcttaat  gtgattttg  tcagcttaa  ttaaagata  aatttcttg  2220
agctggtat  tatgaagtt  ccatcataa  cacagattc  ggtaatcct  ccaaatcaa  2280
tatttccat  ctgcgcgtg  aggtttgcc  gtgtgactc  aacggggac  gcacagatg  2340
ggacaggat  gtgggtgcg  ggcttggca  cggtgccat  attgccatc  tgctctgca  2400
catcatcct  cttatcctt  tgctgatgt  tgtggtatg  atgaaacgc  gggataaag  2460
acgccaggc  aaacaactt  taattgatc  agaagatga  gtaagagat  atattttaa  2520
atatgatga  gaaggtgga  gagaagaag  ccaggacta  gacttgagc  agctgcagc  2580
gcctgacac  gtggagcct  atgccatca  gcctgtggg  atccgacga  tggatgaaa  2640
acccatcca  gctgagccc  agtatccgg  ccgatctgc  gccccacac  ctggagaca  2700
tggggactt  attaatgag  gccttaaag  ggctgacaa  gaccccaca  ctccaccat  2760
tgactccct  ttagtgttt  actatgaag  cagtggctc  actgctggg  ccttgagct  2820
ccttaattc  tcaagtagt  gtggtgagc  ggactatga  tacctgaac  actgggggc  2880
acggttcaa  aaacttgct  acatgtatg  tggaggtga  gactgaact  cagggtgaa  2940
ttggttttt  gacaagtac  aacaatttc  actgatatt  ccaaaaagc  ttcagaagc  3000
aggctttaa  tttgtagtc  actagcaca  tgcttgctg  aggctttgg  ataggctgc  3060
aaccaattt  ggctcagag  gaatatcag  gatccatac  gtttggaaa  acactgagc  3120
cagttacac  tgaatttta  agtacagaa  cactgggat  ttatgtgcc  ttttgtacc  3180
ttttcagat  ggaattagt  ttctgttta  ggctttaat  gtactgatt  ctgaaacga  3240
aagtaaaag  caaaatatt  tgtggtggg  gcagtaagt  aaaccatga  atgcttcaa  3300
acgcttttg  tacattgca  ttgctttta  taaaataca  aattaaaca  acaaaaaaa  3360
tcatggagc  attttatta  cttggggga  gagaccatg  gattggaaa  tgtacatta  3420
ttctagttt  agactttag  ttgtttttt  tttttcact  aaatcttaa  acttactca  3480
ctggttgca  ataaaggga  ttttcatat  accaatttg  agcaaaatt  aattttttc  3540
taaactaga  tgttagaca  attttggtc  taatccatg  acacttttt  atttctgta  3600
ttttccact  cactgtaaa  atagtatgt  tacataatg  tttattggc  tagtctatg  3660
agaagtgca  aaacttcag  acatgtgta  gtattattt  gactatgga  tcaggtttt  3720
tgcatgttt  tatctttcg  tatggataa  gtatttaca  aacagtgac  tttgattca  3780
ttgttgagc  gtagttaga  tactcaatt  ttaattttt  taatttttt  attttttat  3840
ttctttttg  tttggggag  gagaaaagt  cttagcaca  atgttttac  taatttgta  3900
caaaaaaaa  aaaaaggaa  ggaaagaaa  gggtggcct  acactggtg  cactactaa  3960
tgtgtgttt  ttaaaaaaa  aaatggaaa  aaaaaagct  ttaaactgg  gagacttct  4020
acaacagct  tgcctctgt  ttgtgtacc  gaatataaa  gatacacct  tgaccccag  4080
gttctgaat  aaatgctaa  tttggaaaa  aaaaaaaaa  aa  4122



<210> 1295
<211> 906
<212> PRT
<213> Homo sapiens
<308> P19022
<400> 1295

Met Cys Arg Ile Ala Gly Ala Leu Arg Thr Leu Leu Pro Leu Leu Leu 
  1               5                  10                  15
Ala Leu Leu Gln Ala Ser Val Glu Ala Ser Gly Glu Ile Ala Leu Cys 
             20                  25                  30
Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Ser Lys Asp 
         35                  40                  45
Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
     50                  55                  60
Gly Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
 65                  70                  75                  80
Val Asp Glu Asp Gly Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                 85                  90                  95
Ser Glu His Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
             100                105                110
Glu Lys Trp Gln Val Ala Val Lys Leu Ser Leu Lys Pro Thr Leu Thr 
         115                120                125
Glu Glu Ser Val Lys Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro 
     130                135                140
Arg Gln Phe Ser Lys His Ser Gly His Leu Gln Arg Gln Lys Arg Asp 
 145                150                155                160
Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                 165                170                175
Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
             180                185                190
Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
         195                200                205
Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
     210                215                220
Leu Asp Arg Glu Gln Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
 225                230                235                240
Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                 245                250                255
Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
             260                265                270
Asn Gly Thr Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
         275                280                285
Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
     290                295                300
Arg Tyr Arg Ile Val Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
 305                310                315                320
Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                 325                330                335
Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
             340                345                350
Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
         355                360                365
Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
     370                375                380
Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Ile Ile Val 
 385                390                395                400
Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                 405                410                415
Asn Ala Val Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
             420                425                430
Ile Gln Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
         435                440                445
Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
     450                455                460
Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
 465                470                475                480
Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                 485                490                495
Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
             500                505                510
Gly Thr Met Leu Thr Thr Phe Thr Ala Gln Asp Pro Asp Arg Tyr Met 
         515                520                525
Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
     530                535                540
Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
 545                550                555                560
Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                 565                570                575
Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
             580                585                590
Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
         595                600                605
Glu Ala Glu Thr Cys Glu Thr Pro Asp Pro Asn Ser Ile Asn Ile Thr 
     610                615                620
Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
 625                630                635                640
Leu Pro Leu Ser Pro Val Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg 
                 645                650                655
Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
             660                665                670
Ala Gly Ile Tyr Glu Val Pro Ile Ile Ile Thr Asp Ser Gly Asn Pro 
         675                680                685
Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
     690                695                700
Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
 705                710                715                720
Gly Thr Gly Ala Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                 725                730                735
Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
             740                745                750
Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
         755                760                765
Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
     770                775                780
Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
 785                790                795                800
Ile Lys Pro Val Gly Ile Arg Arg Met Asp Glu Arg Pro Ile His Ala 
                 805                810                815
Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
             820                825                830
Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
         835                840                845
Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
     850                855                860
Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
 865                870                875                880
Glu Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                 885                890                895
Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
             900                905



<210> 1296
<211> 3036
<212> DNA
<213> Rattus norvegicus
<308> AF097593
<400> 1296

ccgcctccg  ctcctcgct  ggcccctct  cgcctcatg  gccggatag  gggagggcc  60
cggaccctg  tgccgcttc  ggcggcctt  cttcaggca  ctctggagg  ttctggtga  120
cttgcatta  gcaagactg  atttcctga  gatgtttac  gcgcagtct  accgaagac  180
gtgcacgaa  gccagcctc  tctcaatgt  aaattcagc  actgcaata  aaaaaggaa  240
gttcagtat  aaagcagtg  accagcaga  tttaaggtg  atgaggacg  cacagtgta  300
gctgtgaga  gcttccctc  ctctgcaga  caggcaaag  tcctgatat  tgcccaaga  360
aaagaaacc  aggaaaagt  gcaggtagc  gttaacctg  gcctggagc  cagcctgac  420
gaggagccg  tgaaggaac  acatgaaat  gaagaaata  tattcccta  acaactcgc  480
aagcacagc  gagctctac  aaggcagaa  agagactgg  tcatccctc  gatcaactt  540
ccagaaaac  ccagaggac  ctttccgca  gagcttgtc  gaatcaggt  tgatagaga  600
aagaaccta  ctctgagat  cagtgtcac  gggccagga  ctgaccagc  tccaacggg  660
atcttcatc  tcaacccca  ctctggaca  ctgtcagtc  caaagcctc  ggacagaga  720
ctgatagcc  ggtttcacc  gagggcaca  gcagttgac  tcaatggca  tcaagtgga  780
aaccccatt  acatcgtca  caatgtcat  gacatgaat  ataacagac  tgagtttct  840
caccaggtt  ggaatgggt  tgttccaga  ggatcaaag  ctgggacgt  tgtgatgac  900
gtcactgcc  ttgatgcag  tgacccaaa  gccctgaat  ggatgctga  gtacaggat  960
ctctcccag  cacccagca  cccttctcc  aacatgttt  caatcaaca  cgagaccgg  1020
gacatcatc  ctgtggcag  tggtctgga  cgagagaaa  tgcaacagt  tacgttaat  1080
attcaagcc  ctgacatgg  aggcaatcc  acttacggc  tttcaaaca  agccacagc  1140
gtcatcaca  tgacagatg  caatgacaa  cctccagag  ttactgcca  gactttcta  1200
ggagaagtc  ctgagaaca  agtggatgt  attgtagcc  acctgactg  caccgacaa  1260
gaccagccc  acacaccag  ctggaatgc  gcatacaga  tcagtggtg  agaccccac  1320
ggaaggttc  ccatcctga  agaccccaa  agcaatgat  ggctagtca  agtggtaaa  1380
ccaattgac  ttgaaacga  taggatgtt  gtccttact  ttgctgcag  aaaccaagt  1440
ccattagct  aggggatcc  gcacccacc  cagtcgaca  ccacggtgt  tgtgacagt  1500
attgatgtc  atgaaaatc  ttattttgc  ccaaatcct  aaatcattc  ccaagagga  1560
ggcctccac  caggtacca  gctgaccac  ctcactgct  aggaccccg  tcgatatat  1620
caacagaat  tcagataca  aaagttatc  gaccctgcc  actggctga  aatagaccc  1680
gtgaacggg  agatcacca  tatcgctgt  ctggacaga  agtcgccaa  tgtcaaaaa  1740
aacatctat  atgctacct  ccttgcttc  gacaatgga  tccctccta  gagtggaac  1800
ggaacgctg  aaatctatt  acttgatat  aatgacaac  cccctcagg  gttacctca  1860
gaggccgag  cttgtgaaa  tccagaacc  aattcaatt  acatcacag  gcttgatta  1920
gacatagac  ccaatgcag  gccctttgc  tttgacctt  ccttatccc  agcgaccat  1980
aaaagaaac  ggaccatca  ccggcttaa  ggtgatttt  ctcagctca  tttaaagat  2040
aagtttttg  aagctggca  ctatgaagt  cccatcgtt  tcacagatt  agggaatcc  2100
cccaagtcc  atatttcca  cctgcgtgt  aaagtttgc  aatgtgact  caatggaga  2160
tgcaccgac  tagacagga  cgtgggtgc  gggcttggc  cgggcacca  catcgcgat  2220
cttctgtgt  tcatcatcc  gctgatcct  gtcctcatg  tcgtggtat  gatgaaacg  2280
cgggataaa  agcgccagg  caagcagct  ttaatagac  cagaagatg  tgtaagaga  2340
aacatattg  aatatgatg  agaaggtgg  ggagaggaa  accaggact  tgacttgag  2400
cagctccag  aaccagata  cgtggagcc  gatgccatc  aacctgtgg  aatcagacg  2460
ctagacgag  ggcctatcc  cgctgagcc  cagtatcca  tccgatccg  agccccaca  2520
cctggggat  ttggggact  cattaatga  ggccttaaa  ctgctgaca  tgaccccac  2580
gcgccacca  atgactccc  cttagtctt  gactatgag  gcagcggct  cacggctgg  2640
tccttgagc  ctctcaact  ctccagcag  ggcggggac  aggactatg  ctacctgaa  2700
gactgggga  cccgcttca  gaagctggc  gacatgtat  gtggtggtg  tgactgaac  2760
gcaggacgg  cttggcttt  ggacacgta  gaacagttt  acctgatat  cccaaaaag  2820
atacagaag  taggcttta  ctctgtagt  cactagcac  gtgcttgct  gaggctttg  2880
cgtaggctg  gaaccagtt  gggctccca  ggaatatca  tgatccgat  ctgtctgga  2940
aacaccgag  tcagctaca  ttgaatttt  cagtacaga  gcactggga  tttatgtgc  3000
tttttgtac  tttttcaga  tggaattag  tttctg  3036



<210> 1297
<211> 906
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1Y3
<400> 1297

Met Cys Arg Ile Ala Gly Gly Pro Arg Thr Leu Leu Pro Leu Leu Ala 
  1               5                  10                  15
Ala Leu Leu Gln Ala Ser Leu Glu Ala Ser Gly Glu Leu Ala Leu Cys 
             20                  25                  30
Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Pro Lys Thr 
         35                  40                  45
Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
     50                  55                  60
Arg Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
 65                  70                  75                  80
Val Asp Glu Asp Gly Thr Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                 85                  90                  95
Ala Glu Gln Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
             100                105                110
Glu Lys Trp Gln Val Ala Val Asn Leu Ser Leu Glu Pro Ser Leu Thr 
         115                120                125
Glu Glu Pro Met Lys Glu Pro His Glu Ile Glu Glu Ile Val Phe Pro 
     130                135                140
Arg Gln Leu Ala Lys His Ser Gly Ala Leu Gln Arg Gln Lys Arg Asp 
 145                150                155                160
Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                 165                170                175
Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
             180                185                190
Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
         195                200                205
Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
     210                215                220
Leu Asp Arg Glu Leu Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
 225                230                235                240
Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                 245                250                255
Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
             260                265                270
Asn Gly Ser Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
         275                280                285
Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
     290                295                300
Arg Tyr Arg Ile Leu Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
 305                310                315                320
Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                 325                330                335
Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
             340                345                350
Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
         355                360                365
Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
     370                375                380
Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Val Ile Val 
 385                390                395                400
Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                 405                410                415
Asn Ala Ala Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
             420                425                430
Ile Leu Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
         435                440                445
Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
     450                455                460
Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
 465                470                475                480
Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                 485                490                495
Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
             500                505                510
Gly Thr Met Leu Thr Thr Leu Thr Ala Gln Asp Pro Asp Arg Tyr Met 
         515                520                525
Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
     530                535                540
Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
 545                550                555                560
Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                 565                570                575
Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
             580                585                590
Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
         595                600                605
Glu Ala Glu Thr Cys Glu Thr Pro Glu Pro Asn Ser Ile Asn Ile Thr 
     610                615                620
Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
 625                630                635                640
Leu Pro Leu Ser Pro Ala Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg 
                 645                650                655
Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
             660                665                670
Ala Gly Ile Tyr Glu Val Pro Ile Val Ile Thr Asp Ser Gly Asn Pro 
         675                680                685
Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
     690                695                700
Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
 705                710                715                720
Gly Thr Gly Thr Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                 725                730                735
Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
             740                745                750
Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
         755                760                765
Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
     770                775                780
Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
 785                790                795                800
Ile Lys Pro Val Gly Ile Arg Arg Leu Asp Glu Arg Pro Ile His Ala 
                 805                810                815
Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
             820                825                830
Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
         835                840                845
Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
     850                855                860
Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
 865                870                875                880
Asp Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                 885                890                895
Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
             900                905



<210> 1298
<211> 4122
<212> DNA
<213> Homo sapiens
<308> NM_001792
<400> 1298

tttgtcatc  gctcgctct  cattggcgg  gagcggaga  cagcgaaga  gggggtggg  60
aggggaggg  aagggaagg  ggtggaaac  gcctggagc  gtttctccg  gccgctgtt  120
gtgctgccg  tgcctcctc  tcctccgcc  ccgccgccg  cgccgccgc  tcctccggc  180
cttcgctcg  cccctctcc  cctccatgt  ccggatagc  ggagcgctg  ggaccctgc  240
gccgctgct  gcggccctg  ttcaggcgt  tgtagaggc  tctggtgaa  tcgcattat  300
caagactgg  tttcctgaa  atgtttaca  tgcagtctt  tcgaaggat  tgcatgaag  360
acagcctct  ctcaatgtg  agtttagca  ctgcaatgg  aaaagaaaa  tacaatatg  420
gagcagtga  cctgcagat  ttaaggtgg  tgaagatgg  atggtgtat  ccgtgagaa  480
ctttccact  tcttctgag  atgccaagt  cctgatata  gcccaagac  aagagaccc  540
ggaaaagtg  caagtggca  taaaattga  cctgaagcc  accttaact  aggagtcag  600
gaaggagtc  gcagaagtt  aagaaatag  gttcccaag  caattcagt  agcacagtg  660
ccacctaca  aggcagaag  gagactggg  catccctcc  atcaacttg  cagaaaact  720
caggggacc  tttcctcaa  agcttgtca  gatcaggtc  gatagagat  aaaaccttt  780
actgcggta  agtgtaact  ggccaggag  tgaccagcc  ccaactggt  tcttcatta  840
caaccccat  tcgggtcag  tgtcggtga  aaagcccct  gatcgcgag  agatagccc  900
gtttcattt  agggcacat  cagtagata  taatggaaa  caagtggag  accccattg  960
cattgtcat  aatgttatt  acatgaatg  caacagacc  gagttctta  accaggttt  1020
gaatgggac  gttcctgag  gatcaaagc  tggaacata  gtgatgacc  taacagcaa  1080
tgatgctga  gatcccaat  ccctcaatg  gatgttgag  tacagaatc  tgtctcagg  1140
tccaagcac  ccttcaccc  acatgttta  aatcaacaa  gagactggt  acatcatca  1200
agtggcagc  ggacttgat  gagaaaaag  gcaacagta  acgttaata  ttcaagcta  1260
agacatgga  ggcaatccc  catatggcc  ttcaaacac  gccacggcc  tcatcacag  1320
gacagatgt  aatgacaat  ctccagagt  tactgccat  acgttttat  gtgaagttc  1380
tgagaacag  gtagacatc  tagtagcta  tctaactgt  accgataag  atcaacccc  1440
tacaccagc  tggaacgca  tgtacagaa  cagtggcgg  gatcctact  gacggttcg  1500
catccagac  gacccaaac  gcaacgacg  gttagtcac  gtggtcaaa  caatcgact  1560
tgaaacaaa  aggatgttt  tccttactg  tgctgcaga  aatcaagtg  cattagcca  1620
gggaattca  cacccgcct  agtcaactg  aaccgtgtc  gttacagtt  ttgacgtaa  1680
tgaaaaccc  tattttgcc  ccaatccta  gatcattcg  caagaagaa  ggcttcatg  1740
cggtaccat  ttgacaaca  tcactgctc  ggacccaga  cgatatatg  agcaaaata  1800
tagatacac  aaattatct  atcctgcca  ttggctaaa  atagatcct  tgaatggac  1860
aataactac  attgctgtt  tggaccgag  atcaccaaa  gtgaaaaac  atatatata  1920
tgctacttt  cttgcttct  acaatggaa  tcctcctat  agtggaaca  gaacgctgc  1980
gatctattt  cttgatatt  atgacaatg  ccctcaagt  ttacctcaa  aggcagaga  2040
ttgcgaaac  ccagacccc  attcaatta  tattacagc  cttgattat  acattgatc  2100
aaatgctgg  ccatttgct  ttgatcttc  tttatctcc  gtgactatt  agagaaatt  2160
gaccatcac  cggcttaat  gtgattttg  tcagcttaa  ttaaagata  aatttcttg  2220
agctggtat  tatgaagtt  ccatcataa  cacagattc  ggtaatcct  ccaaatcaa  2280
tatttccat  ctgcgcgtg  aggtttgcc  gtgtgactc  aacggggac  gcacagatg  2340
ggacaggat  gtgggtgcg  ggcttggca  cggtgccat  attgccatc  tgctctgca  2400
catcatcct  cttatcctt  tgctgatgt  tgtggtatg  atgaaacgc  gggataaag  2460
acgccaggc  aaacaactt  taattgatc  agaagatga  gtaagagat  atattttaa  2520
atatgatga  gaaggtgga  gagaagaag  ccaggacta  gacttgagc  agctgcagc  2580
gcctgacac  gtggagcct  atgccatca  gcctgtggg  atccgacga  tggatgaaa  2640
acccatcca  gctgagccc  agtatccgg  ccgatctgc  gccccacac  ctggagaca  2700
tggggactt  attaatgag  gccttaaag  ggctgacaa  gaccccaca  ctccaccat  2760
tgactccct  ttagtgttt  actatgaag  cagtggctc  actgctggg  ccttgagct  2820
ccttaattc  tcaagtagt  gtggtgagc  ggactatga  tacctgaac  actgggggc  2880
acggttcaa  aaacttgct  acatgtatg  tggaggtga  gactgaact  cagggtgaa  2940
ttggttttt  gacaagtac  aacaatttc  actgatatt  ccaaaaagc  ttcagaagc  3000
aggctttaa  tttgtagtc  actagcaca  tgcttgctg  aggctttgg  ataggctgc  3060
aaccaattt  ggctcagag  gaatatcag  gatccatac  gtttggaaa  acactgagc  3120
cagttacac  tgaatttta  agtacagaa  cactgggat  ttatgtgcc  ttttgtacc  3180
ttttcagat  ggaattagt  ttctgttta  ggctttaat  gtactgatt  ctgaaacga  3240
aagtaaaag  caaaatatt  tgtggtggg  gcagtaagt  aaaccatga  atgcttcaa  3300
acgcttttg  tacattgca  ttgctttta  taaaataca  aattaaaca  acaaaaaaa  3360
tcatggagc  attttatta  cttggggga  gagaccatg  gattggaaa  tgtacatta  3420
ttctagttt  agactttag  ttgtttttt  tttttcact  aaatcttaa  acttactca  3480
ctggttgca  ataaaggga  ttttcatat  accaatttg  agcaaaatt  aattttttc  3540
taaactaga  tgttagaca  attttggtc  taatccatg  acacttttt  atttctgta  3600
ttttccact  cactgtaaa  atagtatgt  tacataatg  tttattggc  tagtctatg  3660
agaagtgca  aaacttcag  acatgtgta  gtattattt  gactatgga  tcaggtttt  3720
tgcatgttt  tatctttcg  tatggataa  gtatttaca  aacagtgac  tttgattca  3780
ttgttgagc  gtagttaga  tactcaatt  ttaattttt  taatttttt  attttttat  3840
ttctttttg  tttggggag  gagaaaagt  cttagcaca  atgttttac  taatttgta  3900
caaaaaaaa  aaaaaggaa  ggaaagaaa  gggtggcct  acactggtg  cactactaa  3960
tgtgtgttt  ttaaaaaaa  aaatggaaa  aaaaaagct  ttaaactgg  gagacttct  4020
acaacagct  tgcctctgt  ttgtgtacc  gaatataaa  gatacacct  tgaccccag  4080
gttctgaat  aaatgctaa  tttggaaaa  aaaaaaaaa  aa  4122



<210> 1299
<211> 906
<212> PRT
<213> Homo sapiens
<308> P19022
<400> 1299

Met Cys Arg Ile Ala Gly Ala Leu Arg Thr Leu Leu Pro Leu Leu Leu 
  1               5                  10                  15
Ala Leu Leu Gln Ala Ser Val Glu Ala Ser Gly Glu Ile Ala Leu Cys 
             20                  25                  30
Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Ser Lys Asp 
         35                  40                  45
Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
     50                  55                  60
Gly Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
 65                  70                  75                  80
Val Asp Glu Asp Gly Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                 85                  90                  95
Ser Glu His Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
             100                105                110
Glu Lys Trp Gln Val Ala Val Lys Leu Ser Leu Lys Pro Thr Leu Thr 
         115                120                125
Glu Glu Ser Val Lys Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro 
     130                135                140
Arg Gln Phe Ser Lys His Ser Gly His Leu Gln Arg Gln Lys Arg Asp 
 145                150                155                160
Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                 165                170                175
Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
             180                185                190
Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
         195                200                205
Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
     210                215                220
Leu Asp Arg Glu Gln Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
 225                230                235                240
Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                 245                250                255
Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
             260                265                270
Asn Gly Thr Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
         275                280                285
Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
     290                295                300
Arg Tyr Arg Ile Val Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
 305                310                315                320
Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                 325                330                335
Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
             340                345                350
Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
         355                360                365
Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
     370                375                380
Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Ile Ile Val 
 385                390                395                400
Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                 405                410                415
Asn Ala Val Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
             420                425                430
Ile Gln Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
         435                440                445
Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
     450                455                460
Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
 465                470                475                480
Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                 485                490                495
Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
             500                505                510
Gly Thr Met Leu Thr Thr Phe Thr Ala Gln Asp Pro Asp Arg Tyr Met 
         515                520                525
Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
     530                535                540
Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
 545                550                555                560
Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                 565                570                575
Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
             580                585                590
Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
         595                600                605
Glu Ala Glu Thr Cys Glu Thr Pro Asp Pro Asn Ser Ile Asn Ile Thr 
     610                615                620
Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
 625                630                635                640
Leu Pro Leu Ser Pro Val Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg 
                 645                650                655
Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
             660                665                670
Ala Gly Ile Tyr Glu Val Pro Ile Ile Ile Thr Asp Ser Gly Asn Pro 
         675                680                685
Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
     690                695                700
Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
 705                710                715                720
Gly Thr Gly Ala Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                 725                730                735
Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
             740                745                750
Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
         755                760                765
Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
     770                775                780
Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
 785                790                795                800
Ile Lys Pro Val Gly Ile Arg Arg Met Asp Glu Arg Pro Ile His Ala 
                 805                810                815
Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
             820                825                830
Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
         835                840                845
Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
     850                855                860
Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
 865                870                875                880
Glu Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                 885                890                895
Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
             900                905



<210> 1300
<211> 3036
<212> DNA
<213> Rattus norvegicus
<308> AF097593
<400> 1300

ccgcctccg  ctcctcgct  ggcccctct  cgcctcatg  gccggatag  gggagggcc  60
cggaccctg  tgccgcttc  ggcggcctt  cttcaggca  ctctggagg  ttctggtga  120
cttgcatta  gcaagactg  atttcctga  gatgtttac  gcgcagtct  accgaagac  180
gtgcacgaa  gccagcctc  tctcaatgt  aaattcagc  actgcaata  aaaaaggaa  240
gttcagtat  aaagcagtg  accagcaga  tttaaggtg  atgaggacg  cacagtgta  300
gctgtgaga  gcttccctc  ctctgcaga  caggcaaag  tcctgatat  tgcccaaga  360
aaagaaacc  aggaaaagt  gcaggtagc  gttaacctg  gcctggagc  cagcctgac  420
gaggagccg  tgaaggaac  acatgaaat  gaagaaata  tattcccta  acaactcgc  480
aagcacagc  gagctctac  aaggcagaa  agagactgg  tcatccctc  gatcaactt  540
ccagaaaac  ccagaggac  ctttccgca  gagcttgtc  gaatcaggt  tgatagaga  600
aagaaccta  ctctgagat  cagtgtcac  gggccagga  ctgaccagc  tccaacggg  660
atcttcatc  tcaacccca  ctctggaca  ctgtcagtc  caaagcctc  ggacagaga  720
ctgatagcc  ggtttcacc  gagggcaca  gcagttgac  tcaatggca  tcaagtgga  780
aaccccatt  acatcgtca  caatgtcat  gacatgaat  ataacagac  tgagtttct  840
caccaggtt  ggaatgggt  tgttccaga  ggatcaaag  ctgggacgt  tgtgatgac  900
gtcactgcc  ttgatgcag  tgacccaaa  gccctgaat  ggatgctga  gtacaggat  960
ctctcccag  cacccagca  cccttctcc  aacatgttt  caatcaaca  cgagaccgg  1020
gacatcatc  ctgtggcag  tggtctgga  cgagagaaa  tgcaacagt  tacgttaat  1080
attcaagcc  ctgacatgg  aggcaatcc  acttacggc  tttcaaaca  agccacagc  1140
gtcatcaca  tgacagatg  caatgacaa  cctccagag  ttactgcca  gactttcta  1200
ggagaagtc  ctgagaaca  agtggatgt  attgtagcc  acctgactg  caccgacaa  1260
gaccagccc  acacaccag  ctggaatgc  gcatacaga  tcagtggtg  agaccccac  1320
ggaaggttc  ccatcctga  agaccccaa  agcaatgat  ggctagtca  agtggtaaa  1380
ccaattgac  ttgaaacga  taggatgtt  gtccttact  ttgctgcag  aaaccaagt  1440
ccattagct  aggggatcc  gcacccacc  cagtcgaca  ccacggtgt  tgtgacagt  1500
attgatgtc  atgaaaatc  ttattttgc  ccaaatcct  aaatcattc  ccaagagga  1560
ggcctccac  caggtacca  gctgaccac  ctcactgct  aggaccccg  tcgatatat  1620
caacagaat  tcagataca  aaagttatc  gaccctgcc  actggctga  aatagaccc  1680
gtgaacggg  agatcacca  tatcgctgt  ctggacaga  agtcgccaa  tgtcaaaaa  1740
aacatctat  atgctacct  ccttgcttc  gacaatgga  tccctccta  gagtggaac  1800
ggaacgctg  aaatctatt  acttgatat  aatgacaac  cccctcagg  gttacctca  1860
gaggccgag  cttgtgaaa  tccagaacc  aattcaatt  acatcacag  gcttgatta  1920
gacatagac  ccaatgcag  gccctttgc  tttgacctt  ccttatccc  agcgaccat  1980
aaaagaaac  ggaccatca  ccggcttaa  ggtgatttt  ctcagctca  tttaaagat  2040
aagtttttg  aagctggca  ctatgaagt  cccatcgtt  tcacagatt  agggaatcc  2100
cccaagtcc  atatttcca  cctgcgtgt  aaagtttgc  aatgtgact  caatggaga  2160
tgcaccgac  tagacagga  cgtgggtgc  gggcttggc  cgggcacca  catcgcgat  2220
cttctgtgt  tcatcatcc  gctgatcct  gtcctcatg  tcgtggtat  gatgaaacg  2280
cgggataaa  agcgccagg  caagcagct  ttaatagac  cagaagatg  tgtaagaga  2340
aacatattg  aatatgatg  agaaggtgg  ggagaggaa  accaggact  tgacttgag  2400
cagctccag  aaccagata  cgtggagcc  gatgccatc  aacctgtgg  aatcagacg  2460
ctagacgag  ggcctatcc  cgctgagcc  cagtatcca  tccgatccg  agccccaca  2520
cctggggat  ttggggact  cattaatga  ggccttaaa  ctgctgaca  tgaccccac  2580
gcgccacca  atgactccc  cttagtctt  gactatgag  gcagcggct  cacggctgg  2640
tccttgagc  ctctcaact  ctccagcag  ggcggggac  aggactatg  ctacctgaa  2700
gactgggga  cccgcttca  gaagctggc  gacatgtat  gtggtggtg  tgactgaac  2760
gcaggacgg  cttggcttt  ggacacgta  gaacagttt  acctgatat  cccaaaaag  2820
atacagaag  taggcttta  ctctgtagt  cactagcac  gtgcttgct  gaggctttg  2880
cgtaggctg  gaaccagtt  gggctccca  ggaatatca  tgatccgat  ctgtctgga  2940
aacaccgag  tcagctaca  ttgaatttt  cagtacaga  gcactggga  tttatgtgc  3000
tttttgtac  tttttcaga  tggaattag  tttctg  3036



<210> 1301
<211> 906
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1Y3
<400> 1301

Met Cys Arg Ile Ala Gly Gly Pro Arg Thr Leu Leu Pro Leu Leu Ala 
  1               5                  10                  15
Ala Leu Leu Gln Ala Ser Leu Glu Ala Ser Gly Glu Leu Ala Leu Cys 
             20                  25                  30
Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Pro Lys Thr 
         35                  40                  45
Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
     50                  55                  60
Arg Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
 65                  70                  75                  80
Val Asp Glu Asp Gly Thr Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                 85                  90                  95
Ala Glu Gln Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
             100                105                110
Glu Lys Trp Gln Val Ala Val Asn Leu Ser Leu Glu Pro Ser Leu Thr 
         115                120                125
Glu Glu Pro Met Lys Glu Pro His Glu Ile Glu Glu Ile Val Phe Pro 
     130                135                140
Arg Gln Leu Ala Lys His Ser Gly Ala Leu Gln Arg Gln Lys Arg Asp 
 145                150                155                160
Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                 165                170                175
Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
             180                185                190
Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
         195                200                205
Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
     210                215                220
Leu Asp Arg Glu Leu Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
 225                230                235                240
Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                 245                250                255
Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
             260                265                270
Asn Gly Ser Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
         275                280                285
Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
     290                295                300
Arg Tyr Arg Ile Leu Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
 305                310                315                320
Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                 325                330                335
Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
             340                345                350
Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
         355                360                365
Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
     370                375                380
Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Val Ile Val 
 385                390                395                400
Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                 405                410                415
Asn Ala Ala Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
             420                425                430
Ile Leu Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
         435                440                445
Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
     450                455                460
Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
 465                470                475                480
Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                 485                490                495
Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
             500                505                510
Gly Thr Met Leu Thr Thr Leu Thr Ala Gln Asp Pro Asp Arg Tyr Met 
         515                520                525
Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
     530                535                540
Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
 545                550                555                560
Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                 565                570                575
Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
             580                585                590
Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
         595                600                605
Glu Ala Glu Thr Cys Glu Thr Pro Glu Pro Asn Ser Ile Asn Ile Thr 
     610                615                620
Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
 625                630                635                640
Leu Pro Leu Ser Pro Ala Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg 
                 645                650                655
Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
             660                665                670
Ala Gly Ile Tyr Glu Val Pro Ile Val Ile Thr Asp Ser Gly Asn Pro 
         675                680                685
Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
     690                695                700
Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
 705                710                715                720
Gly Thr Gly Thr Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                 725                730                735
Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
             740                745                750
Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
         755                760                765
Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
     770                775                780
Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
 785                790                795                800
Ile Lys Pro Val Gly Ile Arg Arg Leu Asp Glu Arg Pro Ile His Ala 
                 805                810                815
Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
             820                825                830
Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
         835                840                845
Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
     850                855                860
Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
 865                870                875                880
Asp Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                 885                890                895
Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
             900                905



<210> 1302
<211> 4122
<212> DNA
<213> Homo sapiens
<308> NM_001792
<400> 1302

tttgtcatc  gctcgctct  cattggcgg  gagcggaga  cagcgaaga  gggggtggg  60
aggggaggg  aagggaagg  ggtggaaac  gcctggagc  gtttctccg  gccgctgtt  120
gtgctgccg  tgcctcctc  tcctccgcc  ccgccgccg  cgccgccgc  tcctccggc  180
cttcgctcg  cccctctcc  cctccatgt  ccggatagc  ggagcgctg  ggaccctgc  240
gccgctgct  gcggccctg  ttcaggcgt  tgtagaggc  tctggtgaa  tcgcattat  300
caagactgg  tttcctgaa  atgtttaca  tgcagtctt  tcgaaggat  tgcatgaag  360
acagcctct  ctcaatgtg  agtttagca  ctgcaatgg  aaaagaaaa  tacaatatg  420
gagcagtga  cctgcagat  ttaaggtgg  tgaagatgg  atggtgtat  ccgtgagaa  480
ctttccact  tcttctgag  atgccaagt  cctgatata  gcccaagac  aagagaccc  540
ggaaaagtg  caagtggca  taaaattga  cctgaagcc  accttaact  aggagtcag  600
gaaggagtc  gcagaagtt  aagaaatag  gttcccaag  caattcagt  agcacagtg  660
ccacctaca  aggcagaag  gagactggg  catccctcc  atcaacttg  cagaaaact  720
caggggacc  tttcctcaa  agcttgtca  gatcaggtc  gatagagat  aaaaccttt  780
actgcggta  agtgtaact  ggccaggag  tgaccagcc  ccaactggt  tcttcatta  840
caaccccat  tcgggtcag  tgtcggtga  aaagcccct  gatcgcgag  agatagccc  900
gtttcattt  agggcacat  cagtagata  taatggaaa  caagtggag  accccattg  960
cattgtcat  aatgttatt  acatgaatg  caacagacc  gagttctta  accaggttt  1020
gaatgggac  gttcctgag  gatcaaagc  tggaacata  gtgatgacc  taacagcaa  1080
tgatgctga  gatcccaat  ccctcaatg  gatgttgag  tacagaatc  tgtctcagg  1140
tccaagcac  ccttcaccc  acatgttta  aatcaacaa  gagactggt  acatcatca  1200
agtggcagc  ggacttgat  gagaaaaag  gcaacagta  acgttaata  ttcaagcta  1260
agacatgga  ggcaatccc  catatggcc  ttcaaacac  gccacggcc  tcatcacag  1320
gacagatgt  aatgacaat  ctccagagt  tactgccat  acgttttat  gtgaagttc  1380
tgagaacag  gtagacatc  tagtagcta  tctaactgt  accgataag  atcaacccc  1440
tacaccagc  tggaacgca  tgtacagaa  cagtggcgg  gatcctact  gacggttcg  1500
catccagac  gacccaaac  gcaacgacg  gttagtcac  gtggtcaaa  caatcgact  1560
tgaaacaaa  aggatgttt  tccttactg  tgctgcaga  aatcaagtg  cattagcca  1620
gggaattca  cacccgcct  agtcaactg  aaccgtgtc  gttacagtt  ttgacgtaa  1680
tgaaaaccc  tattttgcc  ccaatccta  gatcattcg  caagaagaa  ggcttcatg  1740
cggtaccat  ttgacaaca  tcactgctc  ggacccaga  cgatatatg  agcaaaata  1800
tagatacac  aaattatct  atcctgcca  ttggctaaa  atagatcct  tgaatggac  1860
aataactac  attgctgtt  tggaccgag  atcaccaaa  gtgaaaaac  atatatata  1920
tgctacttt  cttgcttct  acaatggaa  tcctcctat  agtggaaca  gaacgctgc  1980
gatctattt  cttgatatt  atgacaatg  ccctcaagt  ttacctcaa  aggcagaga  2040
ttgcgaaac  ccagacccc  attcaatta  tattacagc  cttgattat  acattgatc  2100
aaatgctgg  ccatttgct  ttgatcttc  tttatctcc  gtgactatt  agagaaatt  2160
gaccatcac  cggcttaat  gtgattttg  tcagcttaa  ttaaagata  aatttcttg  2220
agctggtat  tatgaagtt  ccatcataa  cacagattc  ggtaatcct  ccaaatcaa  2280
tatttccat  ctgcgcgtg  aggtttgcc  gtgtgactc  aacggggac  gcacagatg  2340
ggacaggat  gtgggtgcg  ggcttggca  cggtgccat  attgccatc  tgctctgca  2400
catcatcct  cttatcctt  tgctgatgt  tgtggtatg  atgaaacgc  gggataaag  2460
acgccaggc  aaacaactt  taattgatc  agaagatga  gtaagagat  atattttaa  2520
atatgatga  gaaggtgga  gagaagaag  ccaggacta  gacttgagc  agctgcagc  2580
gcctgacac  gtggagcct  atgccatca  gcctgtggg  atccgacga  tggatgaaa  2640
acccatcca  gctgagccc  agtatccgg  ccgatctgc  gccccacac  ctggagaca  2700
tggggactt  attaatgag  gccttaaag  ggctgacaa  gaccccaca  ctccaccat  2760
tgactccct  ttagtgttt  actatgaag  cagtggctc  actgctggg  ccttgagct  2820
ccttaattc  tcaagtagt  gtggtgagc  ggactatga  tacctgaac  actgggggc  2880
acggttcaa  aaacttgct  acatgtatg  tggaggtga  gactgaact  cagggtgaa  2940
ttggttttt  gacaagtac  aacaatttc  actgatatt  ccaaaaagc  ttcagaagc  3000
aggctttaa  tttgtagtc  actagcaca  tgcttgctg  aggctttgg  ataggctgc  3060
aaccaattt  ggctcagag  gaatatcag  gatccatac  gtttggaaa  acactgagc  3120
cagttacac  tgaatttta  agtacagaa  cactgggat  ttatgtgcc  ttttgtacc  3180
ttttcagat  ggaattagt  ttctgttta  ggctttaat  gtactgatt  ctgaaacga  3240
aagtaaaag  caaaatatt  tgtggtggg  gcagtaagt  aaaccatga  atgcttcaa  3300
acgcttttg  tacattgca  ttgctttta  taaaataca  aattaaaca  acaaaaaaa  3360
tcatggagc  attttatta  cttggggga  gagaccatg  gattggaaa  tgtacatta  3420
ttctagttt  agactttag  ttgtttttt  tttttcact  aaatcttaa  acttactca  3480
ctggttgca  ataaaggga  ttttcatat  accaatttg  agcaaaatt  aattttttc  3540
taaactaga  tgttagaca  attttggtc  taatccatg  acacttttt  atttctgta  3600
ttttccact  cactgtaaa  atagtatgt  tacataatg  tttattggc  tagtctatg  3660
agaagtgca  aaacttcag  acatgtgta  gtattattt  gactatgga  tcaggtttt  3720
tgcatgttt  tatctttcg  tatggataa  gtatttaca  aacagtgac  tttgattca  3780
ttgttgagc  gtagttaga  tactcaatt  ttaattttt  taatttttt  attttttat  3840
ttctttttg  tttggggag  gagaaaagt  cttagcaca  atgttttac  taatttgta  3900
caaaaaaaa  aaaaaggaa  ggaaagaaa  gggtggcct  acactggtg  cactactaa  3960
tgtgtgttt  ttaaaaaaa  aaatggaaa  aaaaaagct  ttaaactgg  gagacttct  4020
acaacagct  tgcctctgt  ttgtgtacc  gaatataaa  gatacacct  tgaccccag  4080
gttctgaat  aaatgctaa  tttggaaaa  aaaaaaaaa  aa  4122



<210> 1303
<211> 906
<212> PRT
<213> Homo sapiens
<308> P19022
<400> 1303

Met Cys Arg Ile Ala Gly Ala Leu Arg Thr Leu Leu Pro Leu Leu Leu 
  1               5                  10                  15
Ala Leu Leu Gln Ala Ser Val Glu Ala Ser Gly Glu Ile Ala Leu Cys 
             20                  25                  30
Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Ser Lys Asp 
         35                  40                  45
Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
     50                  55                  60
Gly Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
 65                  70                  75                  80
Val Asp Glu Asp Gly Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                 85                  90                  95
Ser Glu His Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
             100                105                110
Glu Lys Trp Gln Val Ala Val Lys Leu Ser Leu Lys Pro Thr Leu Thr 
         115                120                125
Glu Glu Ser Val Lys Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro 
     130                135                140
Arg Gln Phe Ser Lys His Ser Gly His Leu Gln Arg Gln Lys Arg Asp 
 145                150                155                160
Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                 165                170                175
Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
             180                185                190
Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
         195                200                205
Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
     210                215                220
Leu Asp Arg Glu Gln Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
 225                230                235                240
Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                 245                250                255
Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
             260                265                270
Asn Gly Thr Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
         275                280                285
Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
     290                295                300
Arg Tyr Arg Ile Val Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
 305                310                315                320
Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                 325                330                335
Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
             340                345                350
Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
         355                360                365
Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
     370                375                380
Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Ile Ile Val 
 385                390                395                400
Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                 405                410                415
Asn Ala Val Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
             420                425                430
Ile Gln Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
         435                440                445
Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
     450                455                460
Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
 465                470                475                480
Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                 485                490                495
Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
             500                505                510
Gly Thr Met Leu Thr Thr Phe Thr Ala Gln Asp Pro Asp Arg Tyr Met 
         515                520                525
Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
     530                535                540
Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
 545                550                555                560
Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                 565                570                575
Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
             580                585                590
Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
         595                600                605
Glu Ala Glu Thr Cys Glu Thr Pro Asp Pro Asn Ser Ile Asn Ile Thr 
     610                615                620
Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
 625                630                635                640
Leu Pro Leu Ser Pro Val Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg 
                 645                650                655
Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
             660                665                670
Ala Gly Ile Tyr Glu Val Pro Ile Ile Ile Thr Asp Ser Gly Asn Pro 
         675                680                685
Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
     690                695                700
Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
 705                710                715                720
Gly Thr Gly Ala Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                 725                730                735
Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
             740                745                750
Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
         755                760                765
Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
     770                775                780
Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
 785                790                795                800
Ile Lys Pro Val Gly Ile Arg Arg Met Asp Glu Arg Pro Ile His Ala 
                 805                810                815
Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
             820                825                830
Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
         835                840                845
Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
     850                855                860
Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
 865                870                875                880
Glu Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                 885                890                895
Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
             900                905



<210> 1304
<211> 3036
<212> DNA
<213> Rattus norvegicus
<308> AF097593
<400> 1304

ccgcctccg  ctcctcgct  ggcccctct  cgcctcatg  gccggatag  gggagggcc  60
cggaccctg  tgccgcttc  ggcggcctt  cttcaggca  ctctggagg  ttctggtga  120
cttgcatta  gcaagactg  atttcctga  gatgtttac  gcgcagtct  accgaagac  180
gtgcacgaa  gccagcctc  tctcaatgt  aaattcagc  actgcaata  aaaaaggaa  240
gttcagtat  aaagcagtg  accagcaga  tttaaggtg  atgaggacg  cacagtgta  300
gctgtgaga  gcttccctc  ctctgcaga  caggcaaag  tcctgatat  tgcccaaga  360
aaagaaacc  aggaaaagt  gcaggtagc  gttaacctg  gcctggagc  cagcctgac  420
gaggagccg  tgaaggaac  acatgaaat  gaagaaata  tattcccta  acaactcgc  480
aagcacagc  gagctctac  aaggcagaa  agagactgg  tcatccctc  gatcaactt  540
ccagaaaac  ccagaggac  ctttccgca  gagcttgtc  gaatcaggt  tgatagaga  600
aagaaccta  ctctgagat  cagtgtcac  gggccagga  ctgaccagc  tccaacggg  660
atcttcatc  tcaacccca  ctctggaca  ctgtcagtc  caaagcctc  ggacagaga  720
ctgatagcc  ggtttcacc  gagggcaca  gcagttgac  tcaatggca  tcaagtgga  780
aaccccatt  acatcgtca  caatgtcat  gacatgaat  ataacagac  tgagtttct  840
caccaggtt  ggaatgggt  tgttccaga  ggatcaaag  ctgggacgt  tgtgatgac  900
gtcactgcc  ttgatgcag  tgacccaaa  gccctgaat  ggatgctga  gtacaggat  960
ctctcccag  cacccagca  cccttctcc  aacatgttt  caatcaaca  cgagaccgg  1020
gacatcatc  ctgtggcag  tggtctgga  cgagagaaa  tgcaacagt  tacgttaat  1080
attcaagcc  ctgacatgg  aggcaatcc  acttacggc  tttcaaaca  agccacagc  1140
gtcatcaca  tgacagatg  caatgacaa  cctccagag  ttactgcca  gactttcta  1200
ggagaagtc  ctgagaaca  agtggatgt  attgtagcc  acctgactg  caccgacaa  1260
gaccagccc  acacaccag  ctggaatgc  gcatacaga  tcagtggtg  agaccccac  1320
ggaaggttc  ccatcctga  agaccccaa  agcaatgat  ggctagtca  agtggtaaa  1380
ccaattgac  ttgaaacga  taggatgtt  gtccttact  ttgctgcag  aaaccaagt  1440
ccattagct  aggggatcc  gcacccacc  cagtcgaca  ccacggtgt  tgtgacagt  1500
attgatgtc  atgaaaatc  ttattttgc  ccaaatcct  aaatcattc  ccaagagga  1560
ggcctccac  caggtacca  gctgaccac  ctcactgct  aggaccccg  tcgatatat  1620
caacagaat  tcagataca  aaagttatc  gaccctgcc  actggctga  aatagaccc  1680
gtgaacggg  agatcacca  tatcgctgt  ctggacaga  agtcgccaa  tgtcaaaaa  1740
aacatctat  atgctacct  ccttgcttc  gacaatgga  tccctccta  gagtggaac  1800
ggaacgctg  aaatctatt  acttgatat  aatgacaac  cccctcagg  gttacctca  1860
gaggccgag  cttgtgaaa  tccagaacc  aattcaatt  acatcacag  gcttgatta  1920
gacatagac  ccaatgcag  gccctttgc  tttgacctt  ccttatccc  agcgaccat  1980
aaaagaaac  ggaccatca  ccggcttaa  ggtgatttt  ctcagctca  tttaaagat  2040
aagtttttg  aagctggca  ctatgaagt  cccatcgtt  tcacagatt  agggaatcc  2100
cccaagtcc  atatttcca  cctgcgtgt  aaagtttgc  aatgtgact  caatggaga  2160
tgcaccgac  tagacagga  cgtgggtgc  gggcttggc  cgggcacca  catcgcgat  2220
cttctgtgt  tcatcatcc  gctgatcct  gtcctcatg  tcgtggtat  gatgaaacg  2280
cgggataaa  agcgccagg  caagcagct  ttaatagac  cagaagatg  tgtaagaga  2340
aacatattg  aatatgatg  agaaggtgg  ggagaggaa  accaggact  tgacttgag  2400
cagctccag  aaccagata  cgtggagcc  gatgccatc  aacctgtgg  aatcagacg  2460
ctagacgag  ggcctatcc  cgctgagcc  cagtatcca  tccgatccg  agccccaca  2520
cctggggat  ttggggact  cattaatga  ggccttaaa  ctgctgaca  tgaccccac  2580
gcgccacca  atgactccc  cttagtctt  gactatgag  gcagcggct  cacggctgg  2640
tccttgagc  ctctcaact  ctccagcag  ggcggggac  aggactatg  ctacctgaa  2700
gactgggga  cccgcttca  gaagctggc  gacatgtat  gtggtggtg  tgactgaac  2760
gcaggacgg  cttggcttt  ggacacgta  gaacagttt  acctgatat  cccaaaaag  2820
atacagaag  taggcttta  ctctgtagt  cactagcac  gtgcttgct  gaggctttg  2880
cgtaggctg  gaaccagtt  gggctccca  ggaatatca  tgatccgat  ctgtctgga  2940
aacaccgag  tcagctaca  ttgaatttt  cagtacaga  gcactggga  tttatgtgc  3000
tttttgtac  tttttcaga  tggaattag  tttctg  3036



<210> 1305
<211> 906
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1Y3
<400> 1305

Met Cys Arg Ile Ala Gly Gly Pro Arg Thr Leu Leu Pro Leu Leu Ala 
  1               5                  10                  15
Ala Leu Leu Gln Ala Ser Leu Glu Ala Ser Gly Glu Leu Ala Leu Cys 
             20                  25                  30
Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Pro Lys Thr 
         35                  40                  45
Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
     50                  55                  60
Arg Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
 65                  70                  75                  80
Val Asp Glu Asp Gly Thr Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                 85                  90                  95
Ala Glu Gln Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
             100                105                110
Glu Lys Trp Gln Val Ala Val Asn Leu Ser Leu Glu Pro Ser Leu Thr 
         115                120                125
Glu Glu Pro Met Lys Glu Pro His Glu Ile Glu Glu Ile Val Phe Pro 
     130                135                140
Arg Gln Leu Ala Lys His Ser Gly Ala Leu Gln Arg Gln Lys Arg Asp 
 145                150                155                160
Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                 165                170                175
Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
             180                185                190
Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
         195                200                205
Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
     210                215                220
Leu Asp Arg Glu Leu Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
 225                230                235                240
Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                 245                250                255
Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
             260                265                270
Asn Gly Ser Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
         275                280                285
Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
     290                295                300
Arg Tyr Arg Ile Leu Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
 305                310                315                320
Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                 325                330                335
Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
             340                345                350
Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
         355                360                365
Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
     370                375                380
Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Val Ile Val 
 385                390                395                400
Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                 405                410                415
Asn Ala Ala Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
             420                425                430
Ile Leu Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
         435                440                445
Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
     450                455                460
Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
 465                470                475                480
Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                 485                490                495
Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
             500                505                510
Gly Thr Met Leu Thr Thr Leu Thr Ala Gln Asp Pro Asp Arg Tyr Met 
         515                520                525
Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
     530                535                540
Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
 545                550                555                560
Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                 565                570                575
Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
             580                585                590
Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
         595                600                605
Glu Ala Glu Thr Cys Glu Thr Pro Glu Pro Asn Ser Ile Asn Ile Thr 
     610                615                620
Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
 625                630                635                640
Leu Pro Leu Ser Pro Ala Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg 
                 645                650                655
Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
             660                665                670
Ala Gly Ile Tyr Glu Val Pro Ile Val Ile Thr Asp Ser Gly Asn Pro 
         675                680                685
Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
     690                695                700
Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
 705                710                715                720
Gly Thr Gly Thr Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                 725                730                735
Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
             740                745                750
Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
         755                760                765
Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
     770                775                780
Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
 785                790                795                800
Ile Lys Pro Val Gly Ile Arg Arg Leu Asp Glu Arg Pro Ile His Ala 
                 805                810                815
Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
             820                825                830
Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
         835                840                845
Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
     850                855                860
Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
 865                870                875                880
Asp Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                 885                890                895
Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
             900                905



<210> 1306
<211> 4122
<212> DNA
<213> Homo sapiens
<308> NM_001792
<400> 1306

tttgtcatc  gctcgctct  cattggcgg  gagcggaga  cagcgaaga  gggggtggg  60
aggggaggg  aagggaagg  ggtggaaac  gcctggagc  gtttctccg  gccgctgtt  120
gtgctgccg  tgcctcctc  tcctccgcc  ccgccgccg  cgccgccgc  tcctccggc  180
cttcgctcg  cccctctcc  cctccatgt  ccggatagc  ggagcgctg  ggaccctgc  240
gccgctgct  gcggccctg  ttcaggcgt  tgtagaggc  tctggtgaa  tcgcattat  300
caagactgg  tttcctgaa  atgtttaca  tgcagtctt  tcgaaggat  tgcatgaag  360
acagcctct  ctcaatgtg  agtttagca  ctgcaatgg  aaaagaaaa  tacaatatg  420
gagcagtga  cctgcagat  ttaaggtgg  tgaagatgg  atggtgtat  ccgtgagaa  480
ctttccact  tcttctgag  atgccaagt  cctgatata  gcccaagac  aagagaccc  540
ggaaaagtg  caagtggca  taaaattga  cctgaagcc  accttaact  aggagtcag  600
gaaggagtc  gcagaagtt  aagaaatag  gttcccaag  caattcagt  agcacagtg  660
ccacctaca  aggcagaag  gagactggg  catccctcc  atcaacttg  cagaaaact  720
caggggacc  tttcctcaa  agcttgtca  gatcaggtc  gatagagat  aaaaccttt  780
actgcggta  agtgtaact  ggccaggag  tgaccagcc  ccaactggt  tcttcatta  840
caaccccat  tcgggtcag  tgtcggtga  aaagcccct  gatcgcgag  agatagccc  900
gtttcattt  agggcacat  cagtagata  taatggaaa  caagtggag  accccattg  960
cattgtcat  aatgttatt  acatgaatg  caacagacc  gagttctta  accaggttt  1020
gaatgggac  gttcctgag  gatcaaagc  tggaacata  gtgatgacc  taacagcaa  1080
tgatgctga  gatcccaat  ccctcaatg  gatgttgag  tacagaatc  tgtctcagg  1140
tccaagcac  ccttcaccc  acatgttta  aatcaacaa  gagactggt  acatcatca  1200
agtggcagc  ggacttgat  gagaaaaag  gcaacagta  acgttaata  ttcaagcta  1260
agacatgga  ggcaatccc  catatggcc  ttcaaacac  gccacggcc  tcatcacag  1320
gacagatgt  aatgacaat  ctccagagt  tactgccat  acgttttat  gtgaagttc  1380
tgagaacag  gtagacatc  tagtagcta  tctaactgt  accgataag  atcaacccc  1440
tacaccagc  tggaacgca  tgtacagaa  cagtggcgg  gatcctact  gacggttcg  1500
catccagac  gacccaaac  gcaacgacg  gttagtcac  gtggtcaaa  caatcgact  1560
tgaaacaaa  aggatgttt  tccttactg  tgctgcaga  aatcaagtg  cattagcca  1620
gggaattca  cacccgcct  agtcaactg  aaccgtgtc  gttacagtt  ttgacgtaa  1680
tgaaaaccc  tattttgcc  ccaatccta  gatcattcg  caagaagaa  ggcttcatg  1740
cggtaccat  ttgacaaca  tcactgctc  ggacccaga  cgatatatg  agcaaaata  1800
tagatacac  aaattatct  atcctgcca  ttggctaaa  atagatcct  tgaatggac  1860
aataactac  attgctgtt  tggaccgag  atcaccaaa  gtgaaaaac  atatatata  1920
tgctacttt  cttgcttct  acaatggaa  tcctcctat  agtggaaca  gaacgctgc  1980
gatctattt  cttgatatt  atgacaatg  ccctcaagt  ttacctcaa  aggcagaga  2040
ttgcgaaac  ccagacccc  attcaatta  tattacagc  cttgattat  acattgatc  2100
aaatgctgg  ccatttgct  ttgatcttc  tttatctcc  gtgactatt  agagaaatt  2160
gaccatcac  cggcttaat  gtgattttg  tcagcttaa  ttaaagata  aatttcttg  2220
agctggtat  tatgaagtt  ccatcataa  cacagattc  ggtaatcct  ccaaatcaa  2280
tatttccat  ctgcgcgtg  aggtttgcc  gtgtgactc  aacggggac  gcacagatg  2340
ggacaggat  gtgggtgcg  ggcttggca  cggtgccat  attgccatc  tgctctgca  2400
catcatcct  cttatcctt  tgctgatgt  tgtggtatg  atgaaacgc  gggataaag  2460
acgccaggc  aaacaactt  taattgatc  agaagatga  gtaagagat  atattttaa  2520
atatgatga  gaaggtgga  gagaagaag  ccaggacta  gacttgagc  agctgcagc  2580
gcctgacac  gtggagcct  atgccatca  gcctgtggg  atccgacga  tggatgaaa  2640
acccatcca  gctgagccc  agtatccgg  ccgatctgc  gccccacac  ctggagaca  2700
tggggactt  attaatgag  gccttaaag  ggctgacaa  gaccccaca  ctccaccat  2760
tgactccct  ttagtgttt  actatgaag  cagtggctc  actgctggg  ccttgagct  2820
ccttaattc  tcaagtagt  gtggtgagc  ggactatga  tacctgaac  actgggggc  2880
acggttcaa  aaacttgct  acatgtatg  tggaggtga  gactgaact  cagggtgaa  2940
ttggttttt  gacaagtac  aacaatttc  actgatatt  ccaaaaagc  ttcagaagc  3000
aggctttaa  tttgtagtc  actagcaca  tgcttgctg  aggctttgg  ataggctgc  3060
aaccaattt  ggctcagag  gaatatcag  gatccatac  gtttggaaa  acactgagc  3120
cagttacac  tgaatttta  agtacagaa  cactgggat  ttatgtgcc  ttttgtacc  3180
ttttcagat  ggaattagt  ttctgttta  ggctttaat  gtactgatt  ctgaaacga  3240
aagtaaaag  caaaatatt  tgtggtggg  gcagtaagt  aaaccatga  atgcttcaa  3300
acgcttttg  tacattgca  ttgctttta  taaaataca  aattaaaca  acaaaaaaa  3360
tcatggagc  attttatta  cttggggga  gagaccatg  gattggaaa  tgtacatta  3420
ttctagttt  agactttag  ttgtttttt  tttttcact  aaatcttaa  acttactca  3480
ctggttgca  ataaaggga  ttttcatat  accaatttg  agcaaaatt  aattttttc  3540
taaactaga  tgttagaca  attttggtc  taatccatg  acacttttt  atttctgta  3600
ttttccact  cactgtaaa  atagtatgt  tacataatg  tttattggc  tagtctatg  3660
agaagtgca  aaacttcag  acatgtgta  gtattattt  gactatgga  tcaggtttt  3720
tgcatgttt  tatctttcg  tatggataa  gtatttaca  aacagtgac  tttgattca  3780
ttgttgagc  gtagttaga  tactcaatt  ttaattttt  taatttttt  attttttat  3840
ttctttttg  tttggggag  gagaaaagt  cttagcaca  atgttttac  taatttgta  3900
caaaaaaaa  aaaaaggaa  ggaaagaaa  gggtggcct  acactggtg  cactactaa  3960
tgtgtgttt  ttaaaaaaa  aaatggaaa  aaaaaagct  ttaaactgg  gagacttct  4020
acaacagct  tgcctctgt  ttgtgtacc  gaatataaa  gatacacct  tgaccccag  4080
gttctgaat  aaatgctaa  tttggaaaa  aaaaaaaaa  aa  4122



<210> 1307
<211> 906
<212> PRT
<213> Homo sapiens
<308> P19022
<400> 1307

Met Cys Arg Ile Ala Gly Ala Leu Arg Thr Leu Leu Pro Leu Leu Leu 
  1               5                  10                  15
Ala Leu Leu Gln Ala Ser Val Glu Ala Ser Gly Glu Ile Ala Leu Cys 
             20                  25                  30
Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Ser Lys Asp 
         35                  40                  45
Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
     50                  55                  60
Gly Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
 65                  70                  75                  80
Val Asp Glu Asp Gly Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                 85                  90                  95
Ser Glu His Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
             100                105                110
Glu Lys Trp Gln Val Ala Val Lys Leu Ser Leu Lys Pro Thr Leu Thr 
         115                120                125
Glu Glu Ser Val Lys Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro 
     130                135                140
Arg Gln Phe Ser Lys His Ser Gly His Leu Gln Arg Gln Lys Arg Asp 
 145                150                155                160
Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                 165                170                175
Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
             180                185                190
Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
         195                200                205
Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
     210                215                220
Leu Asp Arg Glu Gln Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
 225                230                235                240
Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                 245                250                255
Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
             260                265                270
Asn Gly Thr Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
         275                280                285
Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
     290                295                300
Arg Tyr Arg Ile Val Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
 305                310                315                320
Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                 325                330                335
Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
             340                345                350
Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
         355                360                365
Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
     370                375                380
Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Ile Ile Val 
 385                390                395                400
Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                 405                410                415
Asn Ala Val Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
             420                425                430
Ile Gln Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
         435                440                445
Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
     450                455                460
Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
 465                470                475                480
Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                 485                490                495
Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
             500                505                510
Gly Thr Met Leu Thr Thr Phe Thr Ala Gln Asp Pro Asp Arg Tyr Met 
         515                520                525
Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
     530                535                540
Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
 545                550                555                560
Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                 565                570                575
Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
             580                585                590
Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
         595                600                605
Glu Ala Glu Thr Cys Glu Thr Pro Asp Pro Asn Ser Ile Asn Ile Thr 
     610                615                620
Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
 625                630                635                640
Leu Pro Leu Ser Pro Val Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg 
                 645                650                655
Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
             660                665                670
Ala Gly Ile Tyr Glu Val Pro Ile Ile Ile Thr Asp Ser Gly Asn Pro 
         675                680                685
Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
     690                695                700
Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
 705                710                715                720
Gly Thr Gly Ala Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                 725                730                735
Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
             740                745                750
Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
         755                760                765
Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
     770                775                780
Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
 785                790                795                800
Ile Lys Pro Val Gly Ile Arg Arg Met Asp Glu Arg Pro Ile His Ala 
                 805                810                815
Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
             820                825                830
Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
         835                840                845
Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
     850                855                860
Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
 865                870                875                880
Glu Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                 885                890                895
Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
             900                905



<210> 1308
<211> 931
<212> DNA
<213> Rattus norvegicus
<308> AF099093
<400> 1308

agctccacc  cggtgngcc  ctctagaac  agtggatcc  cgggctnca  gaattcctt  60
cccttccgg  cgtgacgcc  gagaggaaa  ccgagcgga  atctcgcat  ggcagcgag  120
tgcttctcg  gtctcccaa  accggcctc  cgcggcttc  gcgctccag  cgcggggcc  180
gggttcctc  acacacnta  cttcagcca  cgtcagagc  tgtccccca  ccgtcgaag  240
cccggcggc  ccgggcttc  tggtgggga  gatgacgga  ctgcagtcg  cactgctac  300
gcgaagaca  ctggcagaa  tcaacaaaa  tccagtgga  ggcttttca  caggtttaa  360
agacgacaa  gatctctat  gttgggaag  ccttattat  ggtcctcca  atacacttt  420
tgaaggtgg  gtttttaag  ctcatctca  tttcccaaa  gattatccc  tccgacctc  480
taaaatgaa  ttcattaca  agatttggc  cccaaatgt  gataaaaat  gtgatgttt  540
catttctat  cttcatgaa  ctggagagg  taaatatgg  tatgagaag  cagaggaac  600
ctggctgcc  atccatact  tggaaacca  catgattag  gtcatttct  tgctggcag  660
tcctaatgg  gactcacct  caaatgtag  tgctgcgaa  gaatggagg  aagacagaa  720
tggagaatt  aaaaggaaa  ttgcccgct  tgtaagaaa  agccaagaa  ctgcttttg  780
gtgatgttt  ttcaatagc  agtaacttc  cttatttca  ggtctccaa  tgagaaaca  840
ggcactgtt  ttycttgca  ctctaccca  cttattgct  ggacttctg  tgtaacaag  900
tggcaaact  tggctggaa  tgggctgca  t  931



<210> 1309
<211> 170
<212> PRT
<213> Rattus norvegicus
<308> Q99462
<400> 1309

Met Thr Glu Leu Gln Ser Ala Leu Leu Leu Arg Arg Gln Leu Ala Glu 
  1               5                  10                  15
Leu Asn Lys Asn Pro Val Glu Gly Phe Ser Ala Gly Leu Ile Asp Asp 
             20                  25                  30
Asn Asp Leu Tyr Arg Trp Glu Val Leu Ile Ile Gly Pro Pro Asp Thr 
         35                  40                  45
Leu Tyr Glu Gly Gly Val Phe Lys Ala His Leu Thr Phe Pro Lys Asp 
     50                  55                  60
Tyr Pro Leu Arg Pro Pro Lys Met Lys Phe Ile Thr Glu Ile Trp His 
 65                  70                  75                  80
Pro Asn Val Asp Lys Asn Gly Asp Val Cys Ile Ser Ile Leu His Glu 
                 85                  90                  95
Pro Gly Glu Asp Lys Tyr Gly Tyr Glu Lys Pro Glu Glu Arg Trp Leu 
             100                105                110
Pro Ile His Thr Val Glu Thr Ile Met Ile Ser Val Ile Ser Met Leu 
         115                120                125
Ala Asp Pro Asn Gly Asp Ser Pro Ala Asn Val Asp Ala Ala Lys Glu 
     130                135                140
Trp Arg Glu Asp Arg Asn Gly Glu Phe Lys Arg Lys Val Ala Arg Cys 
 145                150                155                160
Val Arg Lys Ser Gln Glu Thr Ala Phe Glu 
                 165                170



<210> 1310
<211> 2430
<212> DNA
<213> Homo sapiens
<308> NM_003342
<400> 1310

accggcagc  aggcgccgc  cccgccgcc  cagcccggc  ttcctcggc  ccggcgctc  60
ggtcgcggg  cccgggttc  tcggcacac  ccgctccag  cgcccccag  gcctgtccc  120
agcccttcg  aagccccgg  gccagcccg  gccctcggc  gggaggatg  cggagctgc  180
gtcggcact  ctactgcga  gacagctgg  agaactcaa  aaaaatcca  tggaaggct  240
ttctgcagg  ttaatagat  acaatgatc  ctaccgatg  gaagtcctt  ttattggcc  300
tccagatac  ctttatgaa  gtggtgttt  taaggctca  cttactttc  caaaagatt  360
tcccctccg  cctcctaaa  tgaaattca  tacagaaat  tggcaccca  atgttgata  420
aaatggtga  gtgtgcatt  ctattcttc  tgagcctgg  gaagataag  atggttatg  480
aaagccaga  gaacgctgg  tccctatcc  cactgtgga  accatcatg  ttagtgtca  540
ttctatgct  gcagaccct  atggagact  acctgctaa  gttgatgct  cgaaagaat  600
gagggaaga  agaaatgga  aatttaaaa  aaaagttgc  cgctgtgta  gaaaaagcc  660
agagactgc  tttgagtga  atttattta  cagctagta  cttcactta  ttcagggtc  720
ccaattgag  aacatggca  tgtttttcc  gcactctac  cacctattg  tggacttct  780
ttgtacaag  tggcaaaca  tggctggaa  tgggctgca  taaaacatg  cagttatca  840
tgctgacaa  agcctaaca  gtgccaact  acagatgat  acgcatttt  aattctaat  900
aactgtttt  accttcagg  agaattgta  agacctgta  atagcacaa  atgatccgg  960
taatatata  actgttcat  tacatccac  aatacacct  gtaccaaat  atgctttct  1020
gtagtagaa  aagaatcgt  taaattcta  gagatttta  caggttttc  ttcctattc  1080
ttgtttctt  tcagtttaa  aggattcct  taagcatgt  agatgaaaa  caattagga  1140
taaaagttt  catttaatt  cccttaaac  cttgaggct  cattaaact  ttttcactt  1200
ctaaacttt  gtatcttct  tgttttgac  cactcccct  tgcttttat  tcttacctg  1260
cagaatgtt  tcaaatgat  tagttcaaa  actgaaata  ttaatgagc  attacttga  1320
ttttaatga  gacttcgaa  gagtcatca  taggtgctt  gtccttttt  tattctagt  1380
gcacccacc  cttggattg  atatagcaa  aacatttat  ggccgttgt  agctcttga  1440
cccagtcat  acccctgag  actaaaaat  gatggttct  aattcaact  actgaaaat  1500
tccccaaac  atagcaaat  tgacttttc  ctcttcagt  gcctggtat  aaggttgga  1560
aaatgaagc  tgcacagct  caggctttc  acttaactt  tgggtttgc  attacaaat  1620
ctatttact  tcataccct  ctccttagt  cttcatatt  ctctgcctc  attcttcta  1680
actgcagat  tttctcacc  attgtacaa  gaaattgcg  tgtatattt  catgtaatt  1740
gattttgga  ttctgtcac  ttatgtagt  agttcttcc  aaatataat  ttttttcaa  1800
aattgtcaa  ttgttggct  ttattgtat  gaatgaagg  tataatact  agtgccaga  1860
aagtggttt  ggaaaatct  aggttgatt  cttatgcaa  tgaactttt  atacttgaa  1920
atcacatgg  catggcagt  tatgtattt  gttctatct  gattcttct  tgaatctaa  1980
agcattaca  gggtaaatg  tttgctatt  gacgtatag  tcccgtcac  aacaatagt  2040
cacttggat  tgattaatg  ttgagcttc  atatatttc  tatcataca  ttttctaaa  2100
caacttcag  aaatggtaa  atgaacatg  gcagtgtta  aggcaggcc  taggctcct  2160
catgtttgt  gtgaggttg  gtgtgggaa  tagtctttg  cttataagg  atagaactt  2220
agacagtag  agatgggac  tggtgtttg  ttgtgagaa  cagtgagaa  tcgtgcatc  2280
ctgctctgt  gggtttgga  aaatgcttt  gcagaagag  gaaagaact  ctgccaaga  2340
cccagacct  tacaaacgt  gtatgtcct  ttttaagca  aaataaaat  gttgaggac  2400
aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  2430



<210> 1311
<211> 170
<212> PRT
<213> Homo sapiens
<308> Q99462
<400> 1311

Met Thr Glu Leu Gln Ser Ala Leu Leu Leu Arg Arg Gln Leu Ala Glu 
  1               5                  10                  15
Leu Asn Lys Asn Pro Val Glu Gly Phe Ser Ala Gly Leu Ile Asp Asp 
             20                  25                  30
Asn Asp Leu Tyr Arg Trp Glu Val Leu Ile Ile Gly Pro Pro Asp Thr 
         35                  40                  45
Leu Tyr Glu Gly Gly Val Phe Lys Ala His Leu Thr Phe Pro Lys Asp 
     50                  55                  60
Tyr Pro Leu Arg Pro Pro Lys Met Lys Phe Ile Thr Glu Ile Trp His 
 65                  70                  75                  80
Pro Asn Val Asp Lys Asn Gly Asp Val Cys Ile Ser Ile Leu His Glu 
                 85                  90                  95
Pro Gly Glu Asp Lys Tyr Gly Tyr Glu Lys Pro Glu Glu Arg Trp Leu 
             100                105                110
Pro Ile His Thr Val Glu Thr Ile Met Ile Ser Val Ile Ser Met Leu 
         115                120                125
Ala Asp Pro Asn Gly Asp Ser Pro Ala Asn Val Asp Ala Ala Lys Glu 
     130                135                140
Trp Arg Glu Asp Arg Asn Gly Glu Phe Lys Arg Lys Val Ala Arg Cys 
 145                150                155                160
Val Arg Lys Ser Gln Glu Thr Ala Phe Glu 
                 165                170



<210> 1312
<211> 931
<212> DNA
<213> Rattus norvegicus
<308> AF099093
<400> 1312

agctccacc  cggtgngcc  ctctagaac  agtggatcc  cgggctnca  gaattcctt  60
cccttccgg  cgtgacgcc  gagaggaaa  ccgagcgga  atctcgcat  ggcagcgag  120
tgcttctcg  gtctcccaa  accggcctc  cgcggcttc  gcgctccag  cgcggggcc  180
gggttcctc  acacacnta  cttcagcca  cgtcagagc  tgtccccca  ccgtcgaag  240
cccggcggc  ccgggcttc  tggtgggga  gatgacgga  ctgcagtcg  cactgctac  300
gcgaagaca  ctggcagaa  tcaacaaaa  tccagtgga  ggcttttca  caggtttaa  360
agacgacaa  gatctctat  gttgggaag  ccttattat  ggtcctcca  atacacttt  420
tgaaggtgg  gtttttaag  ctcatctca  tttcccaaa  gattatccc  tccgacctc  480
taaaatgaa  ttcattaca  agatttggc  cccaaatgt  gataaaaat  gtgatgttt  540
catttctat  cttcatgaa  ctggagagg  taaatatgg  tatgagaag  cagaggaac  600
ctggctgcc  atccatact  tggaaacca  catgattag  gtcatttct  tgctggcag  660
tcctaatgg  gactcacct  caaatgtag  tgctgcgaa  gaatggagg  aagacagaa  720
tggagaatt  aaaaggaaa  ttgcccgct  tgtaagaaa  agccaagaa  ctgcttttg  780
gtgatgttt  ttcaatagc  agtaacttc  cttatttca  ggtctccaa  tgagaaaca  840
ggcactgtt  ttycttgca  ctctaccca  cttattgct  ggacttctg  tgtaacaag  900
tggcaaact  tggctggaa  tgggctgca  t  931



<210> 1313
<211> 170
<212> PRT
<213> Rattus norvegicus
<308> Q99462
<400> 1313

Met Thr Glu Leu Gln Ser Ala Leu Leu Leu Arg Arg Gln Leu Ala Glu 
  1               5                  10                  15
Leu Asn Lys Asn Pro Val Glu Gly Phe Ser Ala Gly Leu Ile Asp Asp 
             20                  25                  30
Asn Asp Leu Tyr Arg Trp Glu Val Leu Ile Ile Gly Pro Pro Asp Thr 
         35                  40                  45
Leu Tyr Glu Gly Gly Val Phe Lys Ala His Leu Thr Phe Pro Lys Asp 
     50                  55                  60
Tyr Pro Leu Arg Pro Pro Lys Met Lys Phe Ile Thr Glu Ile Trp His 
 65                  70                  75                  80
Pro Asn Val Asp Lys Asn Gly Asp Val Cys Ile Ser Ile Leu His Glu 
                 85                  90                  95
Pro Gly Glu Asp Lys Tyr Gly Tyr Glu Lys Pro Glu Glu Arg Trp Leu 
             100                105                110
Pro Ile His Thr Val Glu Thr Ile Met Ile Ser Val Ile Ser Met Leu 
         115                120                125
Ala Asp Pro Asn Gly Asp Ser Pro Ala Asn Val Asp Ala Ala Lys Glu 
     130                135                140
Trp Arg Glu Asp Arg Asn Gly Glu Phe Lys Arg Lys Val Ala Arg Cys 
 145                150                155                160
Val Arg Lys Ser Gln Glu Thr Ala Phe Glu 
                 165                170



<210> 1314
<211> 2430
<212> DNA
<213> Homo sapiens
<308> NM_003342
<400> 1314

accggcagc  aggcgccgc  cccgccgcc  cagcccggc  ttcctcggc  ccggcgctc  60
ggtcgcggg  cccgggttc  tcggcacac  ccgctccag  cgcccccag  gcctgtccc  120
agcccttcg  aagccccgg  gccagcccg  gccctcggc  gggaggatg  cggagctgc  180
gtcggcact  ctactgcga  gacagctgg  agaactcaa  aaaaatcca  tggaaggct  240
ttctgcagg  ttaatagat  acaatgatc  ctaccgatg  gaagtcctt  ttattggcc  300
tccagatac  ctttatgaa  gtggtgttt  taaggctca  cttactttc  caaaagatt  360
tcccctccg  cctcctaaa  tgaaattca  tacagaaat  tggcaccca  atgttgata  420
aaatggtga  gtgtgcatt  ctattcttc  tgagcctgg  gaagataag  atggttatg  480
aaagccaga  gaacgctgg  tccctatcc  cactgtgga  accatcatg  ttagtgtca  540
ttctatgct  gcagaccct  atggagact  acctgctaa  gttgatgct  cgaaagaat  600
gagggaaga  agaaatgga  aatttaaaa  aaaagttgc  cgctgtgta  gaaaaagcc  660
agagactgc  tttgagtga  atttattta  cagctagta  cttcactta  ttcagggtc  720
ccaattgag  aacatggca  tgtttttcc  gcactctac  cacctattg  tggacttct  780
ttgtacaag  tggcaaaca  tggctggaa  tgggctgca  taaaacatg  cagttatca  840
tgctgacaa  agcctaaca  gtgccaact  acagatgat  acgcatttt  aattctaat  900
aactgtttt  accttcagg  agaattgta  agacctgta  atagcacaa  atgatccgg  960
taatatata  actgttcat  tacatccac  aatacacct  gtaccaaat  atgctttct  1020
gtagtagaa  aagaatcgt  taaattcta  gagatttta  caggttttc  ttcctattc  1080
ttgtttctt  tcagtttaa  aggattcct  taagcatgt  agatgaaaa  caattagga  1140
taaaagttt  catttaatt  cccttaaac  cttgaggct  cattaaact  ttttcactt  1200
ctaaacttt  gtatcttct  tgttttgac  cactcccct  tgcttttat  tcttacctg  1260
cagaatgtt  tcaaatgat  tagttcaaa  actgaaata  ttaatgagc  attacttga  1320
ttttaatga  gacttcgaa  gagtcatca  taggtgctt  gtccttttt  tattctagt  1380
gcacccacc  cttggattg  atatagcaa  aacatttat  ggccgttgt  agctcttga  1440
cccagtcat  acccctgag  actaaaaat  gatggttct  aattcaact  actgaaaat  1500
tccccaaac  atagcaaat  tgacttttc  ctcttcagt  gcctggtat  aaggttgga  1560
aaatgaagc  tgcacagct  caggctttc  acttaactt  tgggtttgc  attacaaat  1620
ctatttact  tcataccct  ctccttagt  cttcatatt  ctctgcctc  attcttcta  1680
actgcagat  tttctcacc  attgtacaa  gaaattgcg  tgtatattt  catgtaatt  1740
gattttgga  ttctgtcac  ttatgtagt  agttcttcc  aaatataat  ttttttcaa  1800
aattgtcaa  ttgttggct  ttattgtat  gaatgaagg  tataatact  agtgccaga  1860
aagtggttt  ggaaaatct  aggttgatt  cttatgcaa  tgaactttt  atacttgaa  1920
atcacatgg  catggcagt  tatgtattt  gttctatct  gattcttct  tgaatctaa  1980
agcattaca  gggtaaatg  tttgctatt  gacgtatag  tcccgtcac  aacaatagt  2040
cacttggat  tgattaatg  ttgagcttc  atatatttc  tatcataca  ttttctaaa  2100
caacttcag  aaatggtaa  atgaacatg  gcagtgtta  aggcaggcc  taggctcct  2160
catgtttgt  gtgaggttg  gtgtgggaa  tagtctttg  cttataagg  atagaactt  2220
agacagtag  agatgggac  tggtgtttg  ttgtgagaa  cagtgagaa  tcgtgcatc  2280
ctgctctgt  gggtttgga  aaatgcttt  gcagaagag  gaaagaact  ctgccaaga  2340
cccagacct  tacaaacgt  gtatgtcct  ttttaagca  aaataaaat  gttgaggac  2400
aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  2430



<210> 1315
<211> 170
<212> PRT
<213> Homo sapiens
<308> Q99462
<400> 1315

Met Thr Glu Leu Gln Ser Ala Leu Leu Leu Arg Arg Gln Leu Ala Glu 
  1               5                  10                  15
Leu Asn Lys Asn Pro Val Glu Gly Phe Ser Ala Gly Leu Ile Asp Asp 
             20                  25                  30
Asn Asp Leu Tyr Arg Trp Glu Val Leu Ile Ile Gly Pro Pro Asp Thr 
         35                  40                  45
Leu Tyr Glu Gly Gly Val Phe Lys Ala His Leu Thr Phe Pro Lys Asp 
     50                  55                  60
Tyr Pro Leu Arg Pro Pro Lys Met Lys Phe Ile Thr Glu Ile Trp His 
 65                  70                  75                  80
Pro Asn Val Asp Lys Asn Gly Asp Val Cys Ile Ser Ile Leu His Glu 
                 85                  90                  95
Pro Gly Glu Asp Lys Tyr Gly Tyr Glu Lys Pro Glu Glu Arg Trp Leu 
             100                105                110
Pro Ile His Thr Val Glu Thr Ile Met Ile Ser Val Ile Ser Met Leu 
         115                120                125
Ala Asp Pro Asn Gly Asp Ser Pro Ala Asn Val Asp Ala Ala Lys Glu 
     130                135                140
Trp Arg Glu Asp Arg Asn Gly Glu Phe Lys Arg Lys Val Ala Arg Cys 
 145                150                155                160
Val Arg Lys Ser Gln Glu Thr Ala Phe Glu 
                 165                170



<210> 1316
<211> 931
<212> DNA
<213> Rattus norvegicus
<308> AF099093
<400> 1316

agctccacc  cggtgngcc  ctctagaac  agtggatcc  cgggctnca  gaattcctt  60
cccttccgg  cgtgacgcc  gagaggaaa  ccgagcgga  atctcgcat  ggcagcgag  120
tgcttctcg  gtctcccaa  accggcctc  cgcggcttc  gcgctccag  cgcggggcc  180
gggttcctc  acacacnta  cttcagcca  cgtcagagc  tgtccccca  ccgtcgaag  240
cccggcggc  ccgggcttc  tggtgggga  gatgacgga  ctgcagtcg  cactgctac  300
gcgaagaca  ctggcagaa  tcaacaaaa  tccagtgga  ggcttttca  caggtttaa  360
agacgacaa  gatctctat  gttgggaag  ccttattat  ggtcctcca  atacacttt  420
tgaaggtgg  gtttttaag  ctcatctca  tttcccaaa  gattatccc  tccgacctc  480
taaaatgaa  ttcattaca  agatttggc  cccaaatgt  gataaaaat  gtgatgttt  540
catttctat  cttcatgaa  ctggagagg  taaatatgg  tatgagaag  cagaggaac  600
ctggctgcc  atccatact  tggaaacca  catgattag  gtcatttct  tgctggcag  660
tcctaatgg  gactcacct  caaatgtag  tgctgcgaa  gaatggagg  aagacagaa  720
tggagaatt  aaaaggaaa  ttgcccgct  tgtaagaaa  agccaagaa  ctgcttttg  780
gtgatgttt  ttcaatagc  agtaacttc  cttatttca  ggtctccaa  tgagaaaca  840
ggcactgtt  ttycttgca  ctctaccca  cttattgct  ggacttctg  tgtaacaag  900
tggcaaact  tggctggaa  tgggctgca  t  931



<210> 1317
<211> 170
<212> PRT
<213> Rattus norvegicus
<308> Q99462
<400> 1317

Met Thr Glu Leu Gln Ser Ala Leu Leu Leu Arg Arg Gln Leu Ala Glu 
  1               5                  10                  15
Leu Asn Lys Asn Pro Val Glu Gly Phe Ser Ala Gly Leu Ile Asp Asp 
             20                  25                  30
Asn Asp Leu Tyr Arg Trp Glu Val Leu Ile Ile Gly Pro Pro Asp Thr 
         35                  40                  45
Leu Tyr Glu Gly Gly Val Phe Lys Ala His Leu Thr Phe Pro Lys Asp 
     50                  55                  60
Tyr Pro Leu Arg Pro Pro Lys Met Lys Phe Ile Thr Glu Ile Trp His 
 65                  70                  75                  80
Pro Asn Val Asp Lys Asn Gly Asp Val Cys Ile Ser Ile Leu His Glu 
                 85                  90                  95
Pro Gly Glu Asp Lys Tyr Gly Tyr Glu Lys Pro Glu Glu Arg Trp Leu 
             100                105                110
Pro Ile His Thr Val Glu Thr Ile Met Ile Ser Val Ile Ser Met Leu 
         115                120                125
Ala Asp Pro Asn Gly Asp Ser Pro Ala Asn Val Asp Ala Ala Lys Glu 
     130                135                140
Trp Arg Glu Asp Arg Asn Gly Glu Phe Lys Arg Lys Val Ala Arg Cys 
 145                150                155                160
Val Arg Lys Ser Gln Glu Thr Ala Phe Glu 
                 165                170



<210> 1318
<211> 2430
<212> DNA
<213> Homo sapiens
<308> NM_003342
<400> 1318

accggcagc  aggcgccgc  cccgccgcc  cagcccggc  ttcctcggc  ccggcgctc  60
ggtcgcggg  cccgggttc  tcggcacac  ccgctccag  cgcccccag  gcctgtccc  120
agcccttcg  aagccccgg  gccagcccg  gccctcggc  gggaggatg  cggagctgc  180
gtcggcact  ctactgcga  gacagctgg  agaactcaa  aaaaatcca  tggaaggct  240
ttctgcagg  ttaatagat  acaatgatc  ctaccgatg  gaagtcctt  ttattggcc  300
tccagatac  ctttatgaa  gtggtgttt  taaggctca  cttactttc  caaaagatt  360
tcccctccg  cctcctaaa  tgaaattca  tacagaaat  tggcaccca  atgttgata  420
aaatggtga  gtgtgcatt  ctattcttc  tgagcctgg  gaagataag  atggttatg  480
aaagccaga  gaacgctgg  tccctatcc  cactgtgga  accatcatg  ttagtgtca  540
ttctatgct  gcagaccct  atggagact  acctgctaa  gttgatgct  cgaaagaat  600
gagggaaga  agaaatgga  aatttaaaa  aaaagttgc  cgctgtgta  gaaaaagcc  660
agagactgc  tttgagtga  atttattta  cagctagta  cttcactta  ttcagggtc  720
ccaattgag  aacatggca  tgtttttcc  gcactctac  cacctattg  tggacttct  780
ttgtacaag  tggcaaaca  tggctggaa  tgggctgca  taaaacatg  cagttatca  840
tgctgacaa  agcctaaca  gtgccaact  acagatgat  acgcatttt  aattctaat  900
aactgtttt  accttcagg  agaattgta  agacctgta  atagcacaa  atgatccgg  960
taatatata  actgttcat  tacatccac  aatacacct  gtaccaaat  atgctttct  1020
gtagtagaa  aagaatcgt  taaattcta  gagatttta  caggttttc  ttcctattc  1080
ttgtttctt  tcagtttaa  aggattcct  taagcatgt  agatgaaaa  caattagga  1140
taaaagttt  catttaatt  cccttaaac  cttgaggct  cattaaact  ttttcactt  1200
ctaaacttt  gtatcttct  tgttttgac  cactcccct  tgcttttat  tcttacctg  1260
cagaatgtt  tcaaatgat  tagttcaaa  actgaaata  ttaatgagc  attacttga  1320
ttttaatga  gacttcgaa  gagtcatca  taggtgctt  gtccttttt  tattctagt  1380
gcacccacc  cttggattg  atatagcaa  aacatttat  ggccgttgt  agctcttga  1440
cccagtcat  acccctgag  actaaaaat  gatggttct  aattcaact  actgaaaat  1500
tccccaaac  atagcaaat  tgacttttc  ctcttcagt  gcctggtat  aaggttgga  1560
aaatgaagc  tgcacagct  caggctttc  acttaactt  tgggtttgc  attacaaat  1620
ctatttact  tcataccct  ctccttagt  cttcatatt  ctctgcctc  attcttcta  1680
actgcagat  tttctcacc  attgtacaa  gaaattgcg  tgtatattt  catgtaatt  1740
gattttgga  ttctgtcac  ttatgtagt  agttcttcc  aaatataat  ttttttcaa  1800
aattgtcaa  ttgttggct  ttattgtat  gaatgaagg  tataatact  agtgccaga  1860
aagtggttt  ggaaaatct  aggttgatt  cttatgcaa  tgaactttt  atacttgaa  1920
atcacatgg  catggcagt  tatgtattt  gttctatct  gattcttct  tgaatctaa  1980
agcattaca  gggtaaatg  tttgctatt  gacgtatag  tcccgtcac  aacaatagt  2040
cacttggat  tgattaatg  ttgagcttc  atatatttc  tatcataca  ttttctaaa  2100
caacttcag  aaatggtaa  atgaacatg  gcagtgtta  aggcaggcc  taggctcct  2160
catgtttgt  gtgaggttg  gtgtgggaa  tagtctttg  cttataagg  atagaactt  2220
agacagtag  agatgggac  tggtgtttg  ttgtgagaa  cagtgagaa  tcgtgcatc  2280
ctgctctgt  gggtttgga  aaatgcttt  gcagaagag  gaaagaact  ctgccaaga  2340
cccagacct  tacaaacgt  gtatgtcct  ttttaagca  aaataaaat  gttgaggac  2400
aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  2430



<210> 1319
<211> 170
<212> PRT
<213> Homo sapiens
<308> Q99462
<400> 1319

Met Thr Glu Leu Gln Ser Ala Leu Leu Leu Arg Arg Gln Leu Ala Glu 
  1               5                  10                  15
Leu Asn Lys Asn Pro Val Glu Gly Phe Ser Ala Gly Leu Ile Asp Asp 
             20                  25                  30
Asn Asp Leu Tyr Arg Trp Glu Val Leu Ile Ile Gly Pro Pro Asp Thr 
         35                  40                  45
Leu Tyr Glu Gly Gly Val Phe Lys Ala His Leu Thr Phe Pro Lys Asp 
     50                  55                  60
Tyr Pro Leu Arg Pro Pro Lys Met Lys Phe Ile Thr Glu Ile Trp His 
 65                  70                  75                  80
Pro Asn Val Asp Lys Asn Gly Asp Val Cys Ile Ser Ile Leu His Glu 
                 85                  90                  95
Pro Gly Glu Asp Lys Tyr Gly Tyr Glu Lys Pro Glu Glu Arg Trp Leu 
             100                105                110
Pro Ile His Thr Val Glu Thr Ile Met Ile Ser Val Ile Ser Met Leu 
         115                120                125
Ala Asp Pro Asn Gly Asp Ser Pro Ala Asn Val Asp Ala Ala Lys Glu 
     130                135                140
Trp Arg Glu Asp Arg Asn Gly Glu Phe Lys Arg Lys Val Ala Arg Cys 
 145                150                155                160
Val Arg Lys Ser Gln Glu Thr Ala Phe Glu 
                 165                170



<210> 1320
<211> 931
<212> DNA
<213> Rattus norvegicus
<308> AF099093
<400> 1320

agctccacc  cggtgngcc  ctctagaac  agtggatcc  cgggctnca  gaattcctt  60
cccttccgg  cgtgacgcc  gagaggaaa  ccgagcgga  atctcgcat  ggcagcgag  120
tgcttctcg  gtctcccaa  accggcctc  cgcggcttc  gcgctccag  cgcggggcc  180
gggttcctc  acacacnta  cttcagcca  cgtcagagc  tgtccccca  ccgtcgaag  240
cccggcggc  ccgggcttc  tggtgggga  gatgacgga  ctgcagtcg  cactgctac  300
gcgaagaca  ctggcagaa  tcaacaaaa  tccagtgga  ggcttttca  caggtttaa  360
agacgacaa  gatctctat  gttgggaag  ccttattat  ggtcctcca  atacacttt  420
tgaaggtgg  gtttttaag  ctcatctca  tttcccaaa  gattatccc  tccgacctc  480
taaaatgaa  ttcattaca  agatttggc  cccaaatgt  gataaaaat  gtgatgttt  540
catttctat  cttcatgaa  ctggagagg  taaatatgg  tatgagaag  cagaggaac  600
ctggctgcc  atccatact  tggaaacca  catgattag  gtcatttct  tgctggcag  660
tcctaatgg  gactcacct  caaatgtag  tgctgcgaa  gaatggagg  aagacagaa  720
tggagaatt  aaaaggaaa  ttgcccgct  tgtaagaaa  agccaagaa  ctgcttttg  780
gtgatgttt  ttcaatagc  agtaacttc  cttatttca  ggtctccaa  tgagaaaca  840
ggcactgtt  ttycttgca  ctctaccca  cttattgct  ggacttctg  tgtaacaag  900
tggcaaact  tggctggaa  tgggctgca  t  931



<210> 1321
<211> 170
<212> PRT
<213> Rattus norvegicus
<308> Q99462
<400> 1321

Met Thr Glu Leu Gln Ser Ala Leu Leu Leu Arg Arg Gln Leu Ala Glu 
  1               5                  10                  15
Leu Asn Lys Asn Pro Val Glu Gly Phe Ser Ala Gly Leu Ile Asp Asp 
             20                  25                  30
Asn Asp Leu Tyr Arg Trp Glu Val Leu Ile Ile Gly Pro Pro Asp Thr 
         35                  40                  45
Leu Tyr Glu Gly Gly Val Phe Lys Ala His Leu Thr Phe Pro Lys Asp 
     50                  55                  60
Tyr Pro Leu Arg Pro Pro Lys Met Lys Phe Ile Thr Glu Ile Trp His 
 65                  70                  75                  80
Pro Asn Val Asp Lys Asn Gly Asp Val Cys Ile Ser Ile Leu His Glu 
                 85                  90                  95
Pro Gly Glu Asp Lys Tyr Gly Tyr Glu Lys Pro Glu Glu Arg Trp Leu 
             100                105                110
Pro Ile His Thr Val Glu Thr Ile Met Ile Ser Val Ile Ser Met Leu 
         115                120                125
Ala Asp Pro Asn Gly Asp Ser Pro Ala Asn Val Asp Ala Ala Lys Glu 
     130                135                140
Trp Arg Glu Asp Arg Asn Gly Glu Phe Lys Arg Lys Val Ala Arg Cys 
 145                150                155                160
Val Arg Lys Ser Gln Glu Thr Ala Phe Glu 
                 165                170



<210> 1322
<211> 2430
<212> DNA
<213> Homo sapiens
<308> NM_003342
<400> 1322

accggcagc  aggcgccgc  cccgccgcc  cagcccggc  ttcctcggc  ccggcgctc  60
ggtcgcggg  cccgggttc  tcggcacac  ccgctccag  cgcccccag  gcctgtccc  120
agcccttcg  aagccccgg  gccagcccg  gccctcggc  gggaggatg  cggagctgc  180
gtcggcact  ctactgcga  gacagctgg  agaactcaa  aaaaatcca  tggaaggct  240
ttctgcagg  ttaatagat  acaatgatc  ctaccgatg  gaagtcctt  ttattggcc  300
tccagatac  ctttatgaa  gtggtgttt  taaggctca  cttactttc  caaaagatt  360
tcccctccg  cctcctaaa  tgaaattca  tacagaaat  tggcaccca  atgttgata  420
aaatggtga  gtgtgcatt  ctattcttc  tgagcctgg  gaagataag  atggttatg  480
aaagccaga  gaacgctgg  tccctatcc  cactgtgga  accatcatg  ttagtgtca  540
ttctatgct  gcagaccct  atggagact  acctgctaa  gttgatgct  cgaaagaat  600
gagggaaga  agaaatgga  aatttaaaa  aaaagttgc  cgctgtgta  gaaaaagcc  660
agagactgc  tttgagtga  atttattta  cagctagta  cttcactta  ttcagggtc  720
ccaattgag  aacatggca  tgtttttcc  gcactctac  cacctattg  tggacttct  780
ttgtacaag  tggcaaaca  tggctggaa  tgggctgca  taaaacatg  cagttatca  840
tgctgacaa  agcctaaca  gtgccaact  acagatgat  acgcatttt  aattctaat  900
aactgtttt  accttcagg  agaattgta  agacctgta  atagcacaa  atgatccgg  960
taatatata  actgttcat  tacatccac  aatacacct  gtaccaaat  atgctttct  1020
gtagtagaa  aagaatcgt  taaattcta  gagatttta  caggttttc  ttcctattc  1080
ttgtttctt  tcagtttaa  aggattcct  taagcatgt  agatgaaaa  caattagga  1140
taaaagttt  catttaatt  cccttaaac  cttgaggct  cattaaact  ttttcactt  1200
ctaaacttt  gtatcttct  tgttttgac  cactcccct  tgcttttat  tcttacctg  1260
cagaatgtt  tcaaatgat  tagttcaaa  actgaaata  ttaatgagc  attacttga  1320
ttttaatga  gacttcgaa  gagtcatca  taggtgctt  gtccttttt  tattctagt  1380
gcacccacc  cttggattg  atatagcaa  aacatttat  ggccgttgt  agctcttga  1440
cccagtcat  acccctgag  actaaaaat  gatggttct  aattcaact  actgaaaat  1500
tccccaaac  atagcaaat  tgacttttc  ctcttcagt  gcctggtat  aaggttgga  1560
aaatgaagc  tgcacagct  caggctttc  acttaactt  tgggtttgc  attacaaat  1620
ctatttact  tcataccct  ctccttagt  cttcatatt  ctctgcctc  attcttcta  1680
actgcagat  tttctcacc  attgtacaa  gaaattgcg  tgtatattt  catgtaatt  1740
gattttgga  ttctgtcac  ttatgtagt  agttcttcc  aaatataat  ttttttcaa  1800
aattgtcaa  ttgttggct  ttattgtat  gaatgaagg  tataatact  agtgccaga  1860
aagtggttt  ggaaaatct  aggttgatt  cttatgcaa  tgaactttt  atacttgaa  1920
atcacatgg  catggcagt  tatgtattt  gttctatct  gattcttct  tgaatctaa  1980
agcattaca  gggtaaatg  tttgctatt  gacgtatag  tcccgtcac  aacaatagt  2040
cacttggat  tgattaatg  ttgagcttc  atatatttc  tatcataca  ttttctaaa  2100
caacttcag  aaatggtaa  atgaacatg  gcagtgtta  aggcaggcc  taggctcct  2160
catgtttgt  gtgaggttg  gtgtgggaa  tagtctttg  cttataagg  atagaactt  2220
agacagtag  agatgggac  tggtgtttg  ttgtgagaa  cagtgagaa  tcgtgcatc  2280
ctgctctgt  gggtttgga  aaatgcttt  gcagaagag  gaaagaact  ctgccaaga  2340
cccagacct  tacaaacgt  gtatgtcct  ttttaagca  aaataaaat  gttgaggac  2400
aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  2430



<210> 1323
<211> 170
<212> PRT
<213> Homo sapiens
<308> Q99462
<400> 1323

Met Thr Glu Leu Gln Ser Ala Leu Leu Leu Arg Arg Gln Leu Ala Glu 
  1               5                  10                  15
Leu Asn Lys Asn Pro Val Glu Gly Phe Ser Ala Gly Leu Ile Asp Asp 
             20                  25                  30
Asn Asp Leu Tyr Arg Trp Glu Val Leu Ile Ile Gly Pro Pro Asp Thr 
         35                  40                  45
Leu Tyr Glu Gly Gly Val Phe Lys Ala His Leu Thr Phe Pro Lys Asp 
     50                  55                  60
Tyr Pro Leu Arg Pro Pro Lys Met Lys Phe Ile Thr Glu Ile Trp His 
 65                  70                  75                  80
Pro Asn Val Asp Lys Asn Gly Asp Val Cys Ile Ser Ile Leu His Glu 
                 85                  90                  95
Pro Gly Glu Asp Lys Tyr Gly Tyr Glu Lys Pro Glu Glu Arg Trp Leu 
             100                105                110
Pro Ile His Thr Val Glu Thr Ile Met Ile Ser Val Ile Ser Met Leu 
         115                120                125
Ala Asp Pro Asn Gly Asp Ser Pro Ala Asn Val Asp Ala Ala Lys Glu 
     130                135                140
Trp Arg Glu Asp Arg Asn Gly Glu Phe Lys Arg Lys Val Ala Arg Cys 
 145                150                155                160
Val Arg Lys Ser Gln Glu Thr Ala Phe Glu 
                 165                170



<210> 1324
<211> 7867
<212> DNA
<213> Rattus norvegicus
<308> AF102552
<400> 1324

atggctcat  ccgcttccc  gttaaagaa  aacagggat  tagaaatca  tgcggaaga  60
gagaccgag  aaaaaaaga  gcaccgtaa  cggtcccgg  atcgcaaga  aaagtcgga  120
gccaatgca  gttacttga  agcagctcg  gcggggcac  tggaaaagg  ccttgacta  180
atcaaaaat  gagtggacg  caacatctg  aaccagaat  ggttgaatg  gctccatct  240
gcttccaaa  aaggccatg  ggaagtggt  tccgagctg  tgcagagag  agccaacgt  300
gatgcagcc  caaagaaag  aaacacagc  ttacacatc  catccttgg  tggacaagc  360
gaagtggtc  aggtcttgg  tacgaacgg  gcgaacgtc  acgcacagt  tcagaatgg  420
ttcacgccg  tgtatatgg  ggcccagga  aaccacctg  aagtcgtca  gtttcttct  480
gacaatggt  ccagccaaa  cctggctac  gaggatggc  tcacgccat  ggccgtggc  540
cttcaacaa  gtcacgacc  agtcgtatc  ctcctgctc  agaacgaca  gaagggaaa  600
gtgcgcctc  cagccctcc  catcgcggc  cggaaagat  acaccaaag  ggcagctct  660
ctcctacag  acgacacca  tgcagacat  gagtcaaag  tggtggtga  tagagcaac  720
gagagtggc  tcacctcac  ccacatagc  gcccactac  ggaatatca  tgtggccac  780
ttgctgtta  accgagcgg  tgccgtgga  ttcaccgca  ggaatgaca  cactccttt  840
catgttgcc  cgaaacggg  aaacgcaaa  atggtaaag  tgttgctcg  ccggggtgc  900
aagatcgac  ccaagacca  ggacggtct  accccgctg  actgcgggg  gagaagtgg  960
cacgagcag  tggtagaga  gttgctgga  agagccgcc  ccatccttt  gaaaaccaa  1020
aatggactg  ccccactgc  catggccac  caaggagac  atttaaact  cgtccaact  1080
ctcctccag  acaacgtgc  cgtggatga  gtcaccaac  actacctga  cgccctcca  1140
gtggcggcc  actgcggcc  ttacaaagt  gccaaggtt  ttttggata  gaaagctaa  1200
cccaatgcc  aagccctga  tggcttcac  cctctccat  tcgcctgca  aaagaaccg  1260
atccgagta  tggaactcc  tttgaagca  ggtgcatct  ttcaagccg  aaccgagtc  1320
ggccttacc  caatccatg  cgctgcctt  atgggacat  taaatatcg  gtcacagct  1380
atgcatcat  gagcctccc  aaacaccac  aacgtgaga  gagaaacag  attgcatat  1440
gcggctcgg  cggggcaag  agaagtggt  cggtatttg  tacaagatg  agctcaggt  1500
gaagcaaaa  ctaaggatg  ccagacccc  ctccacatt  cagcccgac  cgggaaggc  1560
gacatagtg  aacaactgt  acagcaagg  gcgtccccg  atgcagcaa  aacttccgg  1620
tacaccccc  ttcaccttt  ggccagaga  gggcatgag  atgtagctg  cttccttct  1680
gaccatgga  catctttat  cataacaac  aagaaggga  tcacgcctc  gcatgtggc  1740
gcaaagtat  ggaagcttg  agtggcaag  ctcctgctg  agaagagtg  gtctcctga  1800
gccgctggg  agagcgggc  aactccact  catgtagca  cacattacg  taatcagaa  1860
gtggccctt  tgcttttgg  ccagggagc  tcaccccac  cagctgcaa  gaacggtta  1920
acgccactg  acatcgccg  caagaagaa  cagatggac  tagccacgt  cctgctgga  1980
tacggtgct  atgcaaacc  ggttacccg  caagggatt  cgtccgtcc  ccttgcagc  2040
caggaaggg  acgtggaca  ggtgtcgct  ctcctcagt  gaaatgcga  cgtcaactt  2100
agcaataag  gcggcctca  cccactcca  ctggcggct  aagaagacc  agtgaacgt  2160
gctgaggtc  ttgtcaacc  aggggccca  gtggatgca  agacaaaga  gggctacac  2220
ccgctccat  tgggctgtc  ctatggaaa  atcaaaata  tcaattttc  gctgcagca  2280
tctgcgaaa  ttaatgcca  gacaaagaa  ggatacacg  cactgcacc  ggcagccca  2340
cagggccac  cacacatca  caacgtcct  ctccagaac  acgcttccc  caatgaact  2400
actgtgaat  ggaacacag  cctggccat  gcccgacgc  ttggctaca  ctcggtggt  2460
gacacccta  aggtcgtga  agaggaaat  atgaccacc  ctaccatca  ggagaagca  2520
aaaatgaat  tcccagaaa  aatgaatga  gtcctcgac  tgtcagacg  tgaagttgg  2580
aaagccagc  cccccgaaa  gctcagtga  ggggaatat  tctcagatg  tgaagaagg  2640
gaagatgcc  tcacagggg  cactgacaa  tatctcggg  cacaggacc  caaggagct  2700
ggcgatgac  ccctgcctg  cgagggcta  gtgggcttc  gtctcggag  ccgttctgc  2760
agccttcgc  ccttcagtt  ggataggtc  tacaccctg  acagaagct  ctatgcgcg  2820
gacagcatg  tgatcgagg  gcttctggt  ccatccaaa  agcagcacc  tccattcac  2880
agggagttt  actccgact  cctcagaca  tacagttgg  cagcagaca  actggacaa  2940
gtgaacctg  tctccagcc  tgtgcattc  gggtttctg  ttagcttta  ggtggacgc  3000
agagggggc  ccatgcgag  aagccgcca  cacgggatg  ggatcatca  ccctccgcg  3060
aagtgtacg  cccccaccc  catcacttg  cgcctggta  agagacata  actggccaa  3120
ccacccccc  tggtggaag  agagggatt  gccagtagg  tggtagaaa  gggtcctgc  3180
ggggcacaa  ttttaggcc  ggtcatagt  gaaatccct  attttgggt  catgagagg  3240
aaggagagg  aactcattg  cctccggag  gagaacgga  agacctgga  ggaacacca  3300
tttgacagc  aaaacgaag  cctctcgga  ctcctcaat  gcatggacg  agaacttga  3360
agcccagaa  agttgggca  aaagcgcat  tgcagaatc  tcacgaagg  tttccccca  3420
tatttcgct  tggtttccc  gattaagca  gaaagcaac  agattggtc  cgaaggtgg  3480
attctgagc  gcaccacgg  ccccctcgt  caggcgtct  tcccagagg  tgccttaac  3540
aaaaggatc  gtgtgggtc  gcaggctca  cccgtacca  aggagactg  gaaaaagat  3600
cttggaaac  aagcaacgt  tagcccaat  gtcacggtg  agccgagga  gaggaaatt  3660
cataagccg  tcaccatga  catcccggt  cccccaccc  cgggagaag  cgtgtccaa  3720
gggtacaag  gggacacca  gcccagcct  cgactcctc  gcagcatta  aggagggac  3780
tcgccggct  agtgggaag  catcacagg  acaaccccg  tgaccttca  aaaggactg  3840
gtgtctttc  caaccaatg  ttcagccag  ttctggctg  cggactgcc  tcaggtgtt  3900
gaaaccgta  ggctagcct  gcagctgta  agagagttg  tatgtgtcc  ctacatggc  3960
aagtttgtt  tttttgcca  aacaaacga  ccagtggaa  cctccctaa  gtgcttctg  4020
atgacagac  acagagtgg  caaaaccct  gagcagcag  agaatttcg  ggaggttgc  4080
agaagcaaa  acatcgagg  tctggaagg  aagcccatc  atgttgatt  ctatggaaa  4140
ctggctcct  tgaccaaag  agggcagca  cttgttttt  acttctatt  tttcaaaga  4200
aacagactg  cattttcca  caaggttag  gacaccagc  aagagccct  cggccgtct  4260
tctttcctg  aggagccga  aacaacaaa  ggattaccc  aaacggctg  ttgcaactt  4320
aatattact  taccggcgc  taaaaaggc  gagaaggca  acagacgcc  gagcttcac  4380
tccctagcc  tacgtaagc  ctacagcta  ttgactgag  ccagcatga  aacagttga  4440
cggagttca  gaacagcaa  atcccttcc  actacttat  cacacaagc  attcttttc  4500
acaagacca  accagtcct  gactacgac  cccataaca  tgcccgggc  ggccaaatc  4560
ggctcctta  ccagctccc  ctctaacac  ccgtcagcg  ctccgttaa  atccatatg  4620
tctgtttca  cgccttctc  gatcaaatc  acgctaggc  cctcaacta  gtcatcagt  4680
aaatccatt  gtgatgtgg  gtctcctat  agatctttc  ggacaattt  ttcgccaat  4740
agaacggtg  catcgccgt  tccatacaa  acccaagta  cctctggta  ccttgggag  4800
gtacccacc  tcacagagg  cacacctat  aagggggtg  ctcccaact  aactttgtc  4860
tctcgaact  ctcctgtga  gaccgcagg  tctctgttg  agaagtcgt  catcaccat  4920
acaccccct  cctccccca  agccaacat  accatgtat  cctccagct  gccatttaa  4980
tccattatc  cgtcagcgg  accgctgat  tcctcccct  taaagtcag  ggtgtctcc  5040
accaagtct  cagctgatg  catctcaac  gctaaagct  cgatggcat  gactctctc  5100
tccccctta  agcagatgt  tggacatgc  gaagtagcg  tagtcaatg  gtctgtttc  5160
cctctgaag  atccttcct  ttccgcttt  attaacgga  gcaaagcca  tgccacatt  5220
caggacaaa  tttctacag  cacaaatgc  gtgagctcg  tggtgagcg  ggcccctga  5280
acggtggag  aagcgctct  caccacaac  gccatgccc  tttccccac  caggtctta  5340
gtttccgct  cagcgccct  tgcttttca  tcccttaga  ctccctctg  cagtgcact  5400
tacaactcc  tcgggcctt  agtaggtgt  actacctca  ccgtaactt  atcgataat  5460
acagtgcca  tatactcgg  aggcaatgt  ttggcagaa  cagcattga  gaaacttcc  5520
gactctaac  cgctcacaa  atcggcagc  gctttgctg  cgcccatta  aacattgac  5580
acggagaca  gtcctcagc  ccatttcaa  cgaacgtca  ctcccgtca  gtcctctct  5640
ttcctggca  cctcggccc  taagccgtc  gtaccatct  ctttatctt  cagtcagga  5700
atcttaaaa  atgtggccg  gatgaagga  gacctcatg  gaatgaccg  catactgca  5760
acggatgtg  ctgaggaga  gccattcca  accgacctc  cccgagaag  gaggataga  5820
gacgaagag  ctttcaaaa  cgttgagaa  gtgaaggaa  acttagtca  agtcagtga  5880
atactcaaa  aggacgtgt  tgtcgagag  aaagggcca  ccaagtccc  aaagagtga  5940
aaaggacac  ctccagaag  tgactggac  gaatttagt  ctgaggaaa  acgagaagc  6000
aggcaggct  ctgccagtc  cgccccatc  ctgcccgag  gagtacatg  aaaggccaa  6060
ctcaccaga  tcatagact  cctgaccaa  gacatcggg  gcagttcac  gaccaactt  6120
aagtacaag  ttgaagagg  taagaagga  ggagaggag  gacagaaga  aattttaaa  6180
ccagccatg  ccttgcagg  gcataaact  aaaatgccg  cagcctcca  gagaccttc  6240
acctccgag  aggaactgt  caagatggc  gactccttt  ttggaacag  tgccatcct  6300
gagtctccc  atgactttt  tcaacatga  caagacaaa  gtcccttgt  cgacagtgg  6360
tttgaaacc  gaagtgaga  aacaccttc  gccccccaa  gtgccgaga  caccggccc  6420
aagccacta  ttcatgaag  ccccatccc  cctgtcatc  cagagacga  aactgaagt  6480
gtccacgtg  tcaggagct  cgagccctc  actggggag  tcccccagt  ccagccaga  6540
gaccccgtg  ctcccaaac  tccccctac  tttatggag  tggaaccaa  gcccaccgc  6600
cttagcatt  aggaaaaag  gaaagcatt  caaatgaaa  ccagtagcg  ggaagagga  6660
cacagtcgg  ttttaagca  aggcatgcg  gtcaaagaa  agactcaca  caccacaac  6720
acgaggatg  tgtatcact  cccgcctgg  agtgagtgt  cctccgaga  gattgagga  6780
accatgtca  tccatgaca  tatgaaggc  tttcagtcc  ggcgagacc  ttccaaaga  6840
ctggcgggg  tgtttgaac  caagtcggc  atgtctccg  atgttgcca  gtctgctgc  6900
gagacctcg  cccagcacg  agagaagga  aaccaaatg  aacccaaac  ggagcgtat  6960
atagaggtc  acatcgaaa  aggtccaca  agtccttgt  agcggacgg  tatcaggat  7020
gcaatagta  ccgatcacc  gggacttag  tggacagag  tggcaaggg  actgaattt  7080
tcagtggat  aaatcaacc  aatacgagt  gaaaatccc  attctttaa  ttctcagag  7140
ttcatgtta  taaaaaagt  ggtgacgag  gacgggaag  atgccacaa  tgatgcctt  7200
acttcggtc  taacaaaaa  taaccgaat  gacatagta  ctctgctgg  aggaccaat  7260
tttgattat  ggaatattt  aggcaccag  agctttgca  atgaaaaca  tgttttcca  7320
gacccagtt  atggttggc  gaacgagac  ccaagtgga  gcctagagt  cccggcgca  7380
gcgcgaaga  taaccggtg  gttactgga  cgtctggac  acagctctg  ccaggttcg  7440
gatcccatt  cctcatacc  cacaggaga  gctgggaag  tcgaagcaa  cggaaacca  7500
gcagaagtc  ttccagaag  aaaggccaa  gcctacttt  ctgaatccc  aaacgatat  7560
gggaaacag  gcatcaagg  gaacttgaa  ccaaaaaca  acggatgtg  tcgcgctga  7620
gaaccagtg  cgcccctca  agcctacca  aaatctcta  aagaaacca  caagcttgt  7680
atagaagac  cacctaaac  ctgtgtgcc  gtcggcatg  aaaagatga  caggactcc  7740
gctgacggc  aagccaggc  caacctcca  gaagaggag  ggtccgcca  gtcagagcc  7800
aagcaggga  aaggctata  ggtgaaaac  aagaaggaa  tccggaatg  ggagaagaa  7860
gcccact  7867



<210> 1325
<211> 2622
<212> PRT
<213> Rattus norvegicus
<308> AAC78143
<400> 1325

Met Ala His Ala Ala Ser Gln Leu Lys Lys Asn Arg Asp Leu Glu Ile 
  1               5                  10                  15
Asn Ala Glu Glu Glu Thr Glu Lys Lys Lys Lys His Arg Lys Arg Ser 
             20                  25                  30
Arg Asp Arg Lys Lys Lys Ser Asp Ala Asn Ala Ser Tyr Leu Arg Ala 
         35                  40                  45
Ala Arg Ala Gly His Leu Glu Lys Ala Leu Asp Tyr Ile Lys Asn Gly 
     50                  55                  60
Val Asp Val Asn Ile Cys Asn Gln Asn Gly Leu Asn Ala Leu His Leu 
 65                  70                  75                  80
Ala Ser Lys Glu Gly His Val Glu Val Val Ser Glu Leu Leu Gln Arg 
                 85                  90                  95
Glu Ala Asn Val Asp Ala Ala Thr Lys Lys Gly Asn Thr Ala Leu His 
             100                105                110
Ile Ala Ser Leu Ala Gly Gln Ala Glu Val Val Lys Val Leu Val Thr 
         115                120                125
Asn Gly Ala Asn Val Asn Ala Gln Ser Gln Asn Gly Phe Thr Pro Leu 
     130                135                140
Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Arg Phe Leu Leu 
 145                150                155                160
Asp Asn Gly Ala Ser Gln Ser Leu Ala Thr Glu Asp Gly Phe Thr Pro 
                 165                170                175
Leu Ala Val Ala Leu Gln Gln Gly His Asp Gln Val Val Ser Leu Leu 
             180                185                190
Leu Glu Asn Asp Thr Lys Gly Lys Val Arg Leu Pro Ala Leu His Ile 
         195                200                205
Ala Ala Arg Lys Asp Asp Thr Lys Ala Ala Ala Leu Leu Leu Gln Asn 
     210                215                220
Asp Thr Asn Ala Asp Ile Glu Ser Lys Met Val Val Asn Arg Ala Thr 
 225                230                235                240
Glu Ser Gly Phe Thr Ser Leu His Ile Ala Ala His Tyr Gly Asn Ile 
                 245                250                255
Asn Val Ala Thr Leu Leu Leu Asn Arg Ala Ala Ala Val Asp Phe Thr 
             260                265                270
Ala Arg Asn Asp Ile Thr Pro Leu His Val Ala Ser Lys Arg Gly Asn 
         275                280                285
Ala Asn Met Val Lys Leu Leu Leu Asp Arg Gly Ala Lys Ile Asp Ala 
     290                295                300
Lys Thr Arg Asp Gly Leu Thr Pro Leu His Cys Gly Ala Arg Ser Gly 
 305                310                315                320
His Glu Gln Val Val Glu Met Leu Leu Asp Arg Ala Ala Pro Ile Leu 
                 325                330                335
Ser Lys Thr Lys Asn Gly Leu Ser Pro Leu His Met Ala Thr Gln Gly 
             340                345                350
Asp His Leu Asn Cys Val Gln Leu Leu Leu Gln His Asn Val Pro Val 
         355                360                365
Asp Asp Val Thr Asn Asp Tyr Leu Thr Ala Leu His Val Ala Ala His 
     370                375                380
Cys Gly His Tyr Lys Val Ala Lys Val Leu Leu Asp Lys Lys Ala Asn 
 385                390                395                400
Pro Asn Ala Lys Ala Leu Asn Gly Phe Thr Pro Leu His Ile Ala Cys 
                 405                410                415
Lys Lys Asn Arg Ile Arg Val Met Glu Leu Leu Leu Lys His Gly Ala 
             420                425                430
Ser Ile Gln Ala Val Thr Glu Ser Gly Leu Thr Pro Ile His Val Ala 
         435                440                445
Ala Phe Met Gly His Val Asn Ile Val Ser Gln Leu Met His His Gly 
     450                455                460
Ala Ser Pro Asn Thr Thr Asn Val Arg Gly Glu Thr Ala Leu His Met 
 465                470                475                480
Ala Ala Arg Ser Gly Gln Ala Glu Val Val Arg Tyr Leu Val Gln Asp 
                 485                490                495
Gly Ala Gln Val Glu Ala Lys Ala Lys Asp Asp Gln Thr Pro Leu His 
             500                505                510
Ile Ser Ala Arg Leu Gly Lys Ala Asp Ile Val Gln Gln Leu Leu Gln 
         515                520                525
Gln Gly Ala Ser Pro Asn Ala Ala Thr Thr Ser Gly Tyr Thr Pro Leu 
     530                535                540
His Leu Ser Ala Arg Glu Gly His Glu Asp Val Ala Ala Phe Leu Leu 
 545                550                555                560
Asp His Gly Ala Ser Leu Ser Ile Thr Thr Lys Lys Gly Phe Thr Pro 
                 565                570                575
Leu His Val Ala Ala Lys Tyr Gly Lys Leu Glu Val Ala Ser Leu Leu 
             580                585                590
Leu Gln Lys Ser Ala Ser Pro Asp Ala Ala Gly Lys Ser Gly Leu Thr 
         595                600                605
Pro Leu His Val Ala Ala His Tyr Asp Asn Gln Lys Val Ala Leu Leu 
     610                615                620
Leu Leu Asp Gln Gly Ala Ser Pro His Ala Ala Ala Lys Asn Gly Tyr 
 625                630                635                640
Thr Pro Leu His Ile Ala Ala Lys Lys Asn Gln Met Asp Ile Ala Thr 
                 645                650                655
Ser Leu Leu Glu Tyr Gly Ala Asp Ala Asn Pro Val Thr Arg Gln Gly 
             660                665                670
Ile Ala Ser Val His Leu Ala Ala Gln Glu Gly His Val Asp Met Val 
         675                680                685
Ser Leu Leu Leu Ser Arg Asn Ala Asn Val Asn Leu Ser Asn Lys Ser 
     690                695                700
Gly Leu Thr Pro Leu His Leu Ala Ala Gln Glu Asp Arg Val Asn Val 
 705                710                715                720
Ala Glu Val Leu Val Asn Gln Gly Ala His Val Asp Ala Gln Thr Lys 
                 725                730                735
Met Gly Tyr Thr Pro Leu His Val Gly Cys His Tyr Gly Asn Ile Lys 
             740                745                750
Ile Val Asn Phe Leu Leu Gln His Ser Ala Lys Val Asn Ala Lys Thr 
         755                760                765
Lys Asn Gly Tyr Thr Pro Leu His Gln Ala Ala Gln Gln Gly His Thr 
     770                775                780
His Ile Ile Asn Val Leu Leu Gln Asn Asn Ala Ser Pro Asn Glu Leu 
 785                790                795                800
Thr Val Asn Gly Asn Thr Ala Leu Ala Ile Ala Arg Arg Leu Gly Tyr 
                 805                810                815
Ile Ser Val Val Asp Thr Leu Lys Val Val Thr Glu Glu Ile Met Thr 
             820                825                830
Thr Thr Thr Ile Thr Glu Lys His Lys Met Asn Val Pro Glu Thr Met 
         835                840                845
Asn Glu Val Leu Asp Met Ser Asp Asp Glu Val Gly Lys Ala Ser Ala 
     850                855                860
Pro Glu Lys Leu Ser Asp Gly Glu Tyr Ile Ser Asp Gly Glu Glu Gly 
 865                870                875                880
Glu Asp Ala Ile Thr Gly Asp Thr Asp Lys Tyr Leu Gly Pro Gln Asp 
                 885                890                895
Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr Val Gly 
             900                905                910
Phe Ser Leu Gly Ala Arg Ser Ala Ser Leu Arg Ser Phe Ser Ser Asp 
         915                920                925
Arg Ser Tyr Thr Leu Asn Arg Ser Ser Tyr Ala Arg Asp Ser Met Met 
     930                935                940
Ile Glu Glu Leu Leu Val Pro Ser Lys Glu Gln His Leu Pro Phe Thr 
 945                950                955                960
Arg Glu Phe Asp Ser Asp Ser Leu Arg His Tyr Ser Trp Ala Ala Asp 
                 965                970                975
Thr Leu Asp Asn Val Asn Leu Val Ser Ser Pro Val His Ser Gly Phe 
             980                985                990
Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly Ser 
         995                1000                1005
Arg His His Gly Met Arg Ile Ile Ile Pro Pro Arg Lys Cys Thr Ala 
     1010                1015                1020
Pro Thr Arg Ile Thr Cys Arg Leu Val Lys Arg His Lys Leu Ala Asn 
 1025                1030                1035                1040
Pro Pro Pro Met Val Glu Gly Glu Gly Leu Ala Ser Arg Leu Val Glu 
                 1045                1050                1055
Met Gly Pro Ala Gly Ala Gln Phe Leu Gly Pro Val Ile Val Glu Ile 
             1060                1065                1070
Pro His Phe Gly Ser Met Arg Gly Lys Glu Arg Glu Leu Ile Val Leu 
         1075                1080                1085
Arg Ser Glu Asn Gly Glu Thr Trp Lys Glu His Gln Phe Asp Ser Lys 
     1090                1095                1100
Asn Glu Asp Leu Ser Glu Leu Leu Asn Gly Met Asp Glu Glu Leu Asp 
 1105                1110                1115                1120
Ser Pro Glu Glu Leu Gly Thr Lys Arg Ile Cys Arg Ile Ile Thr Lys 
                 1125                1130                1135
Asp Phe Pro Gln Tyr Phe Ala Val Val Ser Arg Ile Lys Gln Glu Ser 
             1140                1145                1150
Asn Gln Ile Gly Pro Glu Gly Gly Ile Leu Ser Ser Thr Thr Val Pro 
         1155                1160                1165
Leu Val Gln Ala Ser Phe Pro Glu Gly Ala Leu Thr Lys Arg Ile Arg 
     1170                1175                1180
Val Gly Leu Gln Ala Gln Pro Val Pro Glu Glu Thr Val Lys Lys Ile 
 1185                1190                1195                1200
Leu Gly Asn Lys Ala Thr Phe Ser Pro Ile Val Thr Val Glu Pro Arg 
                 1205                1210                1215
Arg Arg Lys Phe His Lys Pro Ile Thr Met Thr Ile Pro Val Pro Pro 
             1220                1225                1230
Pro Ser Gly Glu Gly Val Ser Asn Gly Tyr Lys Gly Asp Thr Thr Pro 
         1235                1240                1245
Ser Leu Arg Leu Leu Cys Ser Ile Thr Gly Gly Thr Ser Pro Ala Gln 
     1250                1255                1260
Trp Glu Asp Ile Thr Gly Thr Thr Pro Leu Thr Phe Ile Lys Asp Cys 
 1265                1270                1275                1280
Val Ser Phe Thr Thr Asn Val Ser Ala Arg Phe Trp Leu Ala Asp Cys 
                 1285                1290                1295
His Gln Val Leu Glu Thr Val Gly Leu Ala Ser Gln Leu Tyr Arg Glu 
             1300                1305                1310
Leu Ile Cys Val Pro Tyr Met Ala Lys Phe Val Val Phe Ala Lys Thr 
         1315                1320                1325
Asn Asp Pro Val Glu Ser Ser Leu Arg Cys Phe Cys Met Thr Asp Asp 
     1330                1335                1340
Arg Val Asp Lys Thr Leu Glu Gln Gln Glu Asn Phe Glu Glu Val Ala 
 1345                1350                1355                1360
Arg Ser Lys Asp Ile Glu Val Leu Glu Gly Lys Pro Ile Tyr Val Asp 
                 1365                1370                1375
Cys Tyr Gly Asn Leu Ala Pro Leu Thr Lys Gly Gly Gln Gln Leu Val 
             1380                1385                1390
Phe Asn Phe Tyr Ser Phe Lys Glu Asn Arg Leu Pro Phe Ser Ile Lys 
         1395                1400                1405
Val Arg Asp Thr Ser Gln Glu Pro Cys Gly Arg Leu Ser Phe Leu Lys 
     1410                1415                1420
Glu Pro Lys Thr Thr Lys Gly Leu Pro Gln Thr Ala Val Cys Asn Leu 
 1425                1430                1435                1440
Asn Ile Thr Leu Pro Ala His Lys Lys Ala Glu Lys Ala Asp Arg Arg 
                 1445                1450                1455
Gln Ser Phe Thr Ser Leu Ala Leu Arg Lys Arg Tyr Ser Tyr Leu Thr 
             1460                1465                1470
Glu Pro Ser Met Lys Thr Val Glu Arg Ser Ser Gly Thr Ala Arg Ser 
         1475                1480                1485
Leu Pro Thr Thr Tyr Ser His Lys Pro Phe Phe Ser Thr Arg Pro Tyr 
     1490                1495                1500
Gln Ser Trp Thr Thr Thr Pro Ile Thr Val Pro Gly Pro Ala Lys Ser 
 1505                1510                1515                1520
Gly Ser Leu Ser Ser Ser Pro Ser Asn Thr Pro Ser Ala Ser Pro Leu 
                 1525                1530                1535
Lys Ser Ile Trp Ser Val Ser Thr Pro Ser Pro Ile Lys Ser Thr Leu 
             1540                1545                1550
Gly Ala Ser Thr Thr Ser Ser Val Lys Ser Ile Ser Asp Val Ala Ser 
         1555                1560                1565
Pro Ile Arg Ser Phe Arg Thr Ile Ser Ser Pro Ile Arg Thr Val Ala 
     1570                1575                1580
Ser Pro Ser Pro Tyr Asn Thr Gln Val Ala Ser Gly Thr Leu Gly Arg 
 1585                1590                1595                1600
Val Pro Thr Ile Thr Glu Ala Thr Pro Ile Lys Gly Val Ala Pro Asn 
                 1605                1610                1615
Ser Thr Leu Ser Ser Arg Thr Ser Pro Val Thr Thr Ala Gly Ser Leu 
             1620                1625                1630
Leu Glu Lys Ser Ser Ile Thr Met Thr Pro Pro Ala Ser Pro Lys Ala 
         1635                1640                1645
Asn Ile Thr Met Tyr Ser Ser Ser Leu Pro Phe Lys Ser Ile Ile Thr 
     1650                1655                1660
Ser Ala Ala Pro Leu Ile Ser Ser Pro Leu Lys Ser Val Val Ser Pro 
 1665                1670                1675                1680
Thr Lys Ser Ala Ala Asp Val Ile Ser Thr Ala Lys Ala Ala Met Ala 
                 1685                1690                1695
Ser Thr Leu Ser Ser Pro Leu Lys Gln Met Ser Gly His Ala Glu Val 
             1700                1705                1710
Ala Leu Val Asn Gly Ser Val Ser Pro Leu Lys Tyr Pro Ser Ser Ser 
         1715                1720                1725
Ala Leu Ile Asn Gly Cys Lys Ala Thr Ala Thr Leu Gln Asp Lys Ile 
     1730                1735                1740
Ser Thr Ala Thr Asn Ala Val Ser Ser Val Val Ser Ala Ala Pro Asp 
 1745                1750                1755                1760
Thr Val Glu Lys Ala Leu Ser Thr Thr Thr Ala Met Pro Phe Ser Pro 
                 1765                1770                1775
Leu Arg Ser Tyr Val Ser Ala Ala Ala Pro Ser Ala Phe Gln Ser Leu 
             1780                1785                1790
Arg Ala Pro Ser Ala Ser Ala Leu Tyr Asn Ser Leu Gly Pro Ser Val 
         1795                1800                1805
Gly Val Thr Thr Ser Ser Val Thr Ser Ser Ile Ile Thr Val Pro Val 
     1810                1815                1820
Tyr Ser Val Gly Asn Val Leu Ala Glu Pro Ala Leu Lys Lys Leu Pro 
 1825                1830                1835                1840
Asp Ser Asn Ser Leu Thr Lys Ser Ala Ala Ala Leu Leu Ser Pro Ile 
                 1845                1850                1855
Lys Thr Leu Thr Thr Glu Thr Arg Pro Gln Pro His Phe Asn Arg Thr 
             1860                1865                1870
Ser Ser Pro Val Lys Ser Ser Leu Phe Leu Ala Ser Ser Ala Leu Lys 
         1875                1880                1885
Pro Ser Val Pro Ser Ser Leu Ser Ser Ser Gln Glu Ile Leu Lys Asp 
     1890                1895                1900
Val Ala Glu Met Lys Glu Asp Leu Met Arg Met Thr Ala Ile Leu Gln 
 1905                1910                1915                1920
Thr Asp Val Pro Glu Glu Lys Pro Phe Gln Thr Asp Leu Pro Arg Glu 
                 1925                1930                1935
Gly Arg Ile Asp Asp Glu Glu Pro Phe Lys Ile Val Glu Lys Val Lys 
             1940                1945                1950
Glu Asp Leu Val Lys Val Ser Glu Ile Leu Lys Lys Asp Val Cys Val 
         1955                1960                1965
Glu Ser Lys Gly Pro Pro Lys Ser Pro Lys Ser Asp Lys Gly His Ser 
     1970                1975                1980
Pro Glu Asp Asp Trp Thr Glu Phe Ser Ser Glu Glu Ile Arg Glu Ala 
 1985                1990                1995                2000
Arg Gln Ala Ala Ala Ser His Ala Pro Ser Leu Pro Glu Arg Val His 
                 2005                2010                2015
Gly Lys Ala Asn Leu Thr Arg Val Ile Asp Tyr Leu Thr Asn Asp Ile 
             2020                2025                2030
Gly Ser Ser Ser Leu Thr Asn Leu Lys Tyr Lys Phe Glu Glu Ala Lys 
         2035                2040                2045
Lys Glu Gly Glu Glu Arg Gln Lys Arg Ile Leu Lys Pro Ala Met Ala 
     2050                2055                2060
Leu Gln Glu His Lys Leu Lys Met Pro Pro Ala Ser Met Arg Pro Ser 
 2065                2070                2075                2080
Thr Ser Glu Lys Glu Leu Cys Lys Met Ala Asp Ser Phe Phe Gly Thr 
                 2085                2090                2095
Asp Ala Ile Leu Glu Ser Pro Asp Asp Phe Ser Gln His Asp Gln Asp 
             2100                2105                2110
Lys Ser Pro Leu Ser Asp Ser Gly Phe Glu Thr Arg Ser Glu Lys Thr 
         2115                2120                2125
Pro Ser Ala Pro Gln Ser Ala Glu Ser Thr Gly Pro Lys Pro Leu Phe 
     2130                2135                2140
His Glu Val Pro Ile Pro Pro Val Ile Thr Glu Thr Arg Thr Glu Val 
 2145                2150                2155                2160
Val His Val Ile Arg Ser Tyr Glu Pro Ser Thr Gly Glu Ile Pro Gln 
                 2165                2170                2175
Ser Gln Pro Glu Asp Pro Val Ser Pro Lys Pro Pro Pro Thr Phe Met 
             2180                2185                2190
Glu Leu Glu Pro Lys Pro Thr Ala Leu Ser Ile Lys Glu Lys Val Lys 
         2195                2200                2205
Ala Phe Gln Met Lys Ala Ser Ser Glu Glu Glu Asp His Ser Arg Val 
     2210                2215                2220
Leu Ser Lys Gly Met Arg Val Lys Glu Glu Thr His Ile Thr Thr Thr 
 2225                2230                2235                2240
Thr Arg Met Val Tyr His Ser Pro Pro Gly Ser Glu Cys Ala Ser Glu 
                 2245                2250                2255
Arg Ile Glu Glu Thr Met Ser Val His Asp Ile Met Lys Ala Phe Gln 
             2260                2265                2270
Ser Gly Arg Asp Pro Ser Lys Glu Leu Ala Gly Leu Phe Glu His Lys 
         2275                2280                2285
Ser Ala Met Ser Pro Asp Val Ala Lys Ser Ala Ala Glu Thr Ser Ala 
     2290                2295                2300
Gln His Ala Glu Lys Asp Asn Gln Met Lys Pro Lys Leu Glu Arg Ile 
 2305                2310                2315                2320
Ile Glu Val His Ile Glu Lys Gly Pro Gln Ser Pro Cys Glu Arg Thr 
                 2325                2330                2335
Asp Ile Arg Met Ala Ile Val Ala Asp His Leu Gly Leu Ser Trp Thr 
             2340                2345                2350
Glu Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile Asn Gln Ile 
         2355                2360                2365
Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe Met Leu Leu 
     2370                2375                2380
Lys Lys Trp Val Thr Arg Asp Gly Lys Asn Ala Thr Thr Asp Ala Leu 
 2385                2390                2395                2400
Thr Ser Val Leu Thr Lys Ile Asn Arg Ile Asp Ile Val Thr Leu Leu 
                 2405                2410                2415
Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Thr Arg Ser Phe 
             2420                2425                2430
Ala Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Gly Trp Gln Asn 
         2435                2440                2445
Glu Thr Pro Ser Gly Ser Leu Glu Ser Pro Ala Gln Ala Arg Arg Ile 
     2450                2455                2460
Thr Gly Gly Leu Leu Asp Arg Leu Asp Asp Ser Ser Asp Gln Val Arg 
 2465                2470                2475                2480
Asp Pro Ile Thr Ser Tyr Leu Thr Gly Glu Ala Gly Lys Phe Glu Ala 
                 2485                2490                2495
Asn Gly Asn His Ala Glu Val Ile Pro Glu Ala Lys Ala Lys Ala Tyr 
             2500                2505                2510
Phe Pro Glu Ser Gln Asn Asp Ile Gly Lys Gln Ser Ile Lys Glu Asn 
         2515                2520                2525
Leu Lys Pro Lys Thr His Gly Cys Gly Arg Ala Glu Glu Pro Val Ser 
     2530                2535                2540
Pro Leu Thr Ala Tyr Gln Lys Ser Leu Glu Glu Thr Ser Lys Leu Val 
 2545                2550                2555                2560
Ile Glu Asp Ala Pro Lys Pro Cys Val Pro Val Gly Met Lys Lys Met 
                 2565                2570                2575
Thr Arg Thr Pro Ala Asp Gly Lys Ala Arg Leu Asn Leu Gln Glu Glu 
             2580                2585                2590
Glu Gly Ser Ala Arg Ser Glu Pro Lys Gln Gly Glu Gly Tyr Lys Val 
         2595                2600                2605
Lys Thr Lys Lys Glu Ile Arg Asn Val Glu Lys Lys Ala His 
     2610                2615                2620



<210> 1326
<211> 753
<212> DNA
<213> Homo sapiens
<308> NM_021130
<400> 1326

gttttgcag  cgccaccgc  gaggaaaac  gtgtactat  agccatggt  aaccccacc  60
tgttcttcg  cattgccgt  gacggcgag  ccttgggcc  cgtctcctt  gagctgttt  120
cagacaagg  cccaaagac  gcagaaaat  ttcgtgctc  gagcactgg  gagaaagga  180
ttggttata  gggttcctg  tttcacaga  ttattccag  gtttatgtg  cagggtggt  240
acttcacac  ccataatgg  actggtggc  agtccatct  tggggagaa  tttgaagat  300
agaacttca  cctaaagca  acgggtcct  gcatcttgt  catggcaaa  gctggaccc  360
acacaaatg  ttcccagtt  ttcatctgc  ctgccaaga  tgagtggtt  gatggcaag  420
atgtggtgt  tggcaaagt  aaagaaggc  tgaatattg  ggaggccat  gagcgcttt  480
ggtccagga  tggcaagac  agcaagaag  tcaccattg  tgactgtgg  caactcgaa  540
aagtttgac  tgtgtttta  cttaaccac  agatcattc  ttctgtagc  caggagagc  600
cccctccac  ccatttgct  gcagtatcc  agaatcttt  tgctctcgc  gcagttccc  660
ttgggttcc  tgttttcct  gttccctcc  atgcctagc  ggattgcag  gttaagttt  720
tgattatga  ataaaaact  aataacaat  gtc  753



<210> 1327
<211> 164
<212> PRT
<213> Homo sapiens
<308> P05092
<400> 1327

Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro Leu 
  1               5                  10                  15
Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala 
             20                  25                  30
Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys 
         35                  40                  45
Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly 
     50                  55                  60
Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu 
 65                  70                  75                  80
Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile 
                 85                  90                  95
Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe 
             100                105                110
Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val Phe 
         115                120                125
Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg Phe 
     130                135                140
Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys 
 145                150                155                160
Gly Gln Leu Glu 
                 165



<210> 1328
<211> 1215
<212> DNA
<213> Rattus norvegicus
<308> AF106563
<400> 1328

gatatagtg  ttacaggcc  tatgaggat  gtaaagtaa  taatgatta  ggtgattgg  60
tttgggctc  ttgctggct  cttgctttg  gcatacttc  tcagcgagc  acggctaca  120
gttggggac  ttgtgcttt  ggcacttat  tcacccaac  gtacatgcc  ctcaactgg  180
tcggcacct  ctacagaat  atccagact  acttcattg  catggagaa  atgtttgac  240
tgttgaaag  ggaaacaga  gtgaaggac  tccctggag  agggcccct  cgttttcat  300
agggccggg  tgagtttga  aatgtgcac  tcagctacg  tgatgggcg  gagacctta  360
aagatgtgt  cttcactgt  atgcctgga  agacggtgg  tctggtagg  ccatctggg  420
caggaaaga  cacaatttt  cgcctgctg  ttcgcttct  tgacatcag  tctggctgc  480
tccgaatag  tggacagga  atttcacag  taacccaga  ctctctccg  tctcacatt  540
gagttgtgc  caggacact  tctcttcaa  gacaccatt  ccaacaata  ccgctatgg  600
cgtgttaca  ctgggacag  gagatacag  ctgctgctc  ggctgcggg  atccatgat  660
ccatcctgt  tttccctga  gggtatgag  cacaggttg  ggagcgggg  ctgaagctg  720
gtggtggcg  gaagcagcg  gtggccatt  cccgcacca  ccttaaggc  cctgacatc  780
ctctgctgg  tgaggcaac  tcagcactg  atacatcta  tgagagagc  atccaggcc  840
ctctggcca  agtctgcac  acccgcaac  accatcgta  tagcacaca  gctctcaac  900
gtgtcaatg  tgaccagat  cttgtcatc  aggatggct  catcataga  agaggaagg  960
tcgaagccc  gctatcccg  ggtggcgtg  atgctgaga  gtggcagct  cagcaccaa  1020
gacaagaaa  tgtccctga  gactcttaa  ctcaggaca  ggcgtagta  tgaaaggga  1080
gacctcttt  ctctctaaa  gctaactca  gagtgaaag  tgtcccctc  ccttggctt  1140
agttcattc  ggtatagga  tttggtgct  gctattgta  tgggactgt  cagaaagca  1200
caaaggaaa  aaacg  1215



<210> 1329
<211> 294
<212> PRT
<213> Rattus norvegicus
<308> AAC83936
<400> 1329

Met Pro Leu Asn Trp Phe Gly Thr Tyr Tyr Arg Met Ile Gln Thr Asn 
  1               5                  10                  15
Phe Ile Asp Met Glu Asn Met Phe Asp Leu Leu Lys Glu Glu Thr Glu 
             20                  25                  30
Val Lys Asp Val Pro Gly Ala Gly Pro Leu Arg Phe His Lys Gly Arg 
         35                  40                  45
Val Glu Phe Glu Asn Val His Phe Ser Tyr Ala Asp Gly Arg Glu Thr 
     50                  55                  60
Leu Gln Asp Val Ser Phe Thr Val Met Pro Gly Gln Thr Val Ala Leu 
 65                  70                  75                  80
Val Gly Pro Ser Gly Ala Gly Lys Ser Thr Ile Leu Arg Leu Leu Phe 
                 85                  90                  95
Arg Phe Tyr Asp Ile Ser Ser Gly Cys Ile Arg Ile Asp Gly Gln Asp 
             100                105                110
Ile Ser Gln Val Thr Gln Ile Ser Leu Arg Ser His Ile Gly Val Val 
         115                120                125
Pro Arg Thr Leu Ser Leu Gln Arg His His Cys Gln Gln Tyr Pro Leu 
     130                135                140
Trp Pro Cys Tyr Ser Trp Asp Ser Glu Ile Gln Ala Ala Ala Gln Ala 
 145                150                155                160
Ala Gly Ile His Asp Ala Ile Leu Ser Phe Pro Glu Gly Tyr Glu Thr 
                 165                170                175
Gln Val Gly Glu Arg Gly Leu Lys Leu Ser Gly Gly Glu Lys Gln Arg 
             180                185                190
Val Ala Ile Ala Arg Thr Ile Leu Lys Ala Pro Asp Ile Thr Leu Leu 
         195                200                205
Asp Glu Ala Thr Ser Ala Leu Asp Thr Ser Asn Glu Arg Ala Ile Gln 
     210                215                220
Ala Ser Leu Ala Lys Val Cys Thr Thr Arg Asn His His Arg Ser Ser 
 225                230                235                240
Thr Gln Ala Leu Asn Cys Val Asn Ala Asp Gln Ile Leu Val Ile Lys 
                 245                250                255
Asp Gly Cys Ile Ile Glu Arg Gly Arg Leu Glu Ala Leu Leu Ser Arg 
             260                265                270
Gly Gly Val Tyr Ala Glu Met Trp Gln Leu Gln His Gln Gly Gln Glu 
         275                280                285
Thr Val Pro Glu Asp Ser 
     290



<210> 1330
<211> 1725
<212> DNA
<213> Homo sapiens
<308> AF070598
<400> 1330

ccttcctgt  gatccgggt  cagcagttc  cgtctcggc  ggtggagct  ctcatcttc  60
cccacctgc  cgagctctc  ctgcgctgg  acctggggc  ccgcacagg  gaggtgctg  120
ggatcgcgg  tcggggcac  tccagtgtc  cagggctgc  cagctacct  gtgttcaat  180
tcatcccca  gctggccga  atcatcatt  gcatcatct  cttcagcat  ttcttcaac  240
cctggtttg  cctcattgt  ttcctgtgc  tgagtcttt  cctcaccct  accattgtg  300
tcactgagt  gagaaccaa  tttcgtcgt  ctatgaaca  acaggagaa  gctacccgg  360
cacgagcag  ggactctct  ctaaacttc  agacggtga  gtattacaa  gccgagagt  420
acgaagtgg  acgctatcg  gaggccatc  tcaaatatc  gggtttgga  tggaagtcg  480
gcgcttcac  ggttttact  aatcagacc  agaacctgg  gattgggct  gggctcctc  540
ccggctccc  gctttgcgc  tactttgtc  ctgagcaga  gctacaggt  ggggactat  600
tgctctttg  cacctacat  atccagctg  acatgcccc  caattggtt  ggcacctac  660
acaggatga  ccagaccaa  ttcattgac  tggagaaca  gtttgactt  ctgaaagag  720
agacagaag  gaaggacct  cctggagca  ggccccttc  ctttcagaa  ggccgtatt  780
agtttgaga  cgtgcactt  agctatgcc  atgggcggg  gactctgca  gacgtgtct  840
tcactgtga  gcctggaca  acacttgcc  tggtgggcc  atctggggc  gggaagagc  900
caattttgc  cctgctgtt  cgcttctac  acatcagct  tggctgcat  cgaatagat  960
ggcaggaca  ttcacaggt  acccaggcc  ctctccggt  tcacattgg  gttgtgccc  1020
aagacactg  cctctttaa  gacaccatc  ccgacaata  ccgttacgg  cgtgtcaca  1080
ctgggaatg  tgaggtgga  gctgctgct  aggctgcag  catccatga  gccattatg  1140
ctttccctg  agggtacag  acacaggtg  gcgagcggg  actgaagct  agcggcggg  1200
agaagcagc  cgtcgccat  gcccgcacc  tcctcaagg  tccgggcat  attctgctg  1260
atgaggcaa  gtcagcgct  gatacatct  atgagaggg  catccaggc  tctctggcc  1320
aagtctgtg  caaccgcac  accatcgta  tggcacaca  gctctcaac  gtggtcaat  1380
ctgaccaga  cctcgtcat  aaggatggc  gcatcgtgg  gaggggacg  cacgaggct  1440
tgttgtccc  aggtggggt  tatgctgac  tgtggcagc  gcagcaggg  caggaagaa  1500
cctctgaag  cactaagcc  cagaccatg  aacggtgac  aaagtttgg  cacttccct  1560
tcaaagact  acccagaag  gaataagat  tgtctcctt  ccctggctt  tttcatcct  1620
gtcttgggg  atggtgcta  ctatggtaa  ggaaaggga  ctttccgaa  aacatcttt  1680
ggggaaata  aaatgtgga  tgtgaaaaa  aaaaaaaaa  aaaaa  1725



<210> 1331
<211> 842
<212> PRT
<213> Homo sapiens
<308> Q9NP58
<400> 1331

Met Val Thr Val Gly Asn Tyr Cys Glu Ala Glu Gly Pro Val Gly Pro 
  1               5                  10                  15
Ala Trp Met Gln Asp Gly Leu Ser Pro Cys Phe Phe Phe Thr Leu Val 
             20                  25                  30
Pro Ser Thr Arg Met Ala Leu Gly Thr Leu Ala Leu Val Leu Ala Leu 
         35                  40                  45
Pro Cys Arg Arg Arg Glu Arg Pro Ala Gly Ala Asp Ser Leu Ser Trp 
     50                  55                  60
Gly Ala Gly Pro Arg Ile Ser Pro Tyr Val Leu Gln Leu Leu Leu Ala 
 65                  70                  75                  80
Thr Leu Gln Ala Ala Leu Pro Leu Ala Gly Leu Ala Gly Arg Val Gly 
                 85                  90                  95
Thr Ala Arg Gly Ala Pro Leu Pro Ser Tyr Leu Leu Leu Ala Ser Val 
             100                105                110
Leu Glu Ser Leu Ala Gly Ala Cys Gly Leu Trp Leu Leu Val Val Glu 
         115                120                125
Arg Ser Gln Ala Arg Gln Arg Leu Ala Met Gly Ile Trp Ile Lys Phe 
     130                135                140
Arg His Ser Pro Gly Leu Leu Leu Leu Trp Thr Val Ala Phe Ala Ala 
 145                150                155                160
Glu Asn Leu Ala Leu Val Ser Trp Asn Ser Pro Gln Trp Trp Trp Ala 
                 165                170                175
Arg Ala Asp Leu Gly Gln Gln Val Gln Phe Ser Leu Trp Val Leu Arg 
             180                185                190
Tyr Val Val Ser Gly Gly Leu Phe Val Leu Gly Leu Trp Ala Pro Gly 
         195                200                205
Leu Arg Pro Gln Ser Tyr Thr Leu Gln Val His Glu Glu Asp Gln Asp 
     210                215                220
Val Glu Arg Ser Gln Val Arg Ser Ala Ala Gln Gln Ser Thr Trp Arg 
 225                230                235                240
Asp Phe Gly Arg Lys Leu Arg Leu Leu Ser Gly Tyr Leu Trp Pro Arg 
                 245                250                255
Gly Ser Pro Ala Leu Gln Leu Val Val Leu Ile Cys Leu Gly Leu Met 
             260                265                270
Gly Leu Glu Arg Ala Leu Asn Val Leu Val Pro Ile Phe Tyr Arg Asn 
         275                280                285
Ile Val Asn Leu Leu Thr Glu Lys Ala Pro Trp Asn Ser Leu Ala Trp 
     290                295                300
Thr Val Thr Ser Tyr Val Phe Leu Lys Phe Leu Gln Gly Gly Gly Thr 
 305                310                315                320
Gly Ser Thr Gly Phe Val Ser Asn Leu Arg Thr Phe Leu Trp Ile Arg 
                 325                330                335
Val Gln Gln Phe Thr Ser Arg Arg Val Glu Leu Leu Ile Phe Ser His 
             340                345                350
Leu His Glu Leu Ser Leu Arg Trp His Leu Gly Arg Arg Thr Gly Glu 
         355                360                365
Val Leu Arg Ile Ala Asp Arg Gly Thr Ser Ser Val Thr Gly Leu Leu 
     370                375                380
Ser Tyr Leu Val Phe Asn Val Ile Pro Thr Leu Ala Asp Ile Ile Ile 
 385                390                395                400
Gly Ile Ile Tyr Phe Ser Met Phe Phe Asn Ala Trp Phe Gly Leu Ile 
                 405                410                415
Val Phe Leu Cys Met Ser Leu Tyr Leu Thr Leu Thr Ile Val Val Thr 
             420                425                430
Glu Trp Arg Thr Lys Phe Arg Arg Ala Met Asn Thr Gln Glu Asn Ala 
         435                440                445
Thr Arg Ala Arg Ala Val Asp Ser Leu Leu Asn Phe Glu Thr Val Lys 
     450                455                460
Tyr Tyr Asn Ala Glu Ser Tyr Glu Val Glu Arg Tyr Arg Glu Ala Ile 
 465                470                475                480
Ile Lys Tyr Gln Gly Leu Glu Trp Lys Ser Ser Ala Ser Leu Val Leu 
                 485                490                495
Leu Asn Gln Thr Gln Asn Leu Val Ile Gly Leu Gly Leu Leu Ala Gly 
             500                505                510
Ser Leu Leu Cys Ala Tyr Phe Val Thr Glu Gln Lys Leu Gln Val Gly 
         515                520                525
Asp Tyr Val Leu Phe Gly Thr Tyr Ile Ile Gln Leu Tyr Met Pro Leu 
     530                535                540
Asn Trp Phe Gly Thr Tyr Tyr Arg Met Ile Gln Thr Asn Phe Ile Asp 
 545                550                555                560
Met Glu Asn Met Phe Asp Leu Leu Lys Glu Glu Thr Glu Val Lys Asp 
                 565                570                575
Leu Pro Gly Ala Gly Pro Leu Arg Phe Gln Lys Gly Arg Ile Glu Phe 
             580                585                590
Glu Asn Val His Phe Ser Tyr Ala Asp Gly Arg Glu Thr Leu Gln Asp 
         595                600                605
Val Ser Phe Thr Val Met Pro Gly Gln Thr Leu Ala Leu Val Gly Pro 
     610                615                620
Ser Gly Ala Gly Lys Ser Thr Ile Leu Arg Leu Leu Phe Arg Phe Tyr 
 625                630                635                640
Asp Ile Ser Ser Gly Cys Ile Arg Ile Asp Gly Gln Asp Ile Ser Gln 
                 645                650                655
Val Thr Gln Ala Ser Leu Arg Ser His Ile Gly Val Val Pro Gln Asp 
             660                665                670
Thr Val Leu Phe Asn Asp Thr Ile Ala Asp Asn Ile Arg Tyr Gly Arg 
         675                680                685
Val Thr Ala Gly Asn Asp Glu Val Glu Ala Ala Ala Gln Ala Ala Gly 
     690                695                700
Ile His Asp Ala Ile Met Ala Phe Pro Glu Gly Tyr Arg Thr Gln Val 
 705                710                715                720
Gly Glu Arg Gly Leu Lys Leu Ser Gly Gly Glu Lys Gln Arg Val Ala 
                 725                730                735
Ile Ala Arg Thr Ile Leu Lys Ala Pro Gly Ile Ile Leu Leu Asp Glu 
             740                745                750
Ala Thr Ser Ala Leu Asp Thr Ser Asn Glu Arg Ala Ile Gln Ala Ser 
         755                760                765
Leu Ala Lys Val Cys Ala Asn Arg Thr Thr Ile Val Val Ala His Arg 
     770                775                780
Leu Ser Thr Val Val Asn Ala Asp Gln Ile Leu Val Ile Lys Asp Gly 
 785                790                795                800
Cys Ile Val Glu Arg Gly Arg His Glu Ala Leu Leu Ser Arg Gly Gly 
                 805                810                815
Val Tyr Ala Asp Met Trp Gln Leu Gln Gln Gly Gln Glu Glu Thr Ser 
             820                825                830
Glu Asp Thr Lys Pro Gln Thr Met Glu Arg 
         835                840



<210> 1332
<211> 3288
<212> DNA
<213> Rattus norvegicus
<308> AF109405
<400> 1332

ccggggccc  tgccggcgc  attgcgcgg  agccgcggg  aaagctcgg  gccgggcgg  60
gggccgggc  aggccatgc  ggccgagtg  gctggcgcc  gcagcccgc  gcgcggcat  120
gcttccccg  cgagctccg  gcagccccg  ccgccgccg  cgccgccgc  gcccgcgcg  180
ctgctgctg  ccctgctgc  gtcgctgct  ctgtggttg  cgcccgggg  ctggggctg  240
acgcggggc  ccccccggc  gccgcccag  agcccgccg  tctccatca  gggcctcat  300
ccgctcacc  aggaggtgg  caagggcag  atcgggcgc  gcgtgctcc  cgccgtgga  360
ctagccatc  agcagatcc  caacgagtc  ctcctgcgc  cctacttcc  ggacctgcg  420
ctctatgac  ccgagtgtg  caatgcaaa  ggactgaaa  ccttctatg  cgcaataaa  480
tatgggccg  accatttga  ggtgtttgg  ggcgtctgt  cgtctgtca  atctattat  540
gcggagtcc  tccaaggct  gaatctggt  cagctttcc  tcgccgcca  cacgcctgt  600
cttgcggat  agaagaagt  cccgtattt  ttccggacg  tgccgtcag  caacgcggt  660
aaccccgcc  tcctgaagc  cctgaagca  ttccgctgg  ggcgtgtgg  cacactcac  720
caggacgtg  agcgcttct  cgaggtgag  aatgacctg  ctggggttc  gtatgggga  780
gatattgag  tctcagaca  agagagctt  tccaatgat  cctgcacca  cgtcaaaaa  840
ctcaagggg  atgacgtgc  gatcatcct  ggccagttt  accagaata  ggcagcaaa  900
gtcttctgt  gtgccttcg  ggagagcat  tttggcagc  agtaccagt  gatcatccc  960
ggatggtac  agcctgcgt  gtgggagca  gtgcatgtg  aggccaatt  ctcacgctg  1020
ctgcgcaga  gcctcctgg  tgccatgga  ggttacatc  gagtggact  tgagcccct  1080
agctccaaa  aaatcaaga  catttcagg  aagactcca  agcagtatg  aagagagta  1140
aacagcaaa  gttcaggcg  ggggcccag  aagttccat  ggtacgcct  cgatgggat  1200
tgggtcatc  ccaagaccc  acagagggc  atggagaca  tgcatgcca  tagcaggca  1260
cagcggatc  aggacttca  ctacacaga  cacacgctg  gcaaaatca  cctcaatgc  1320
atgaacgag  ccaacttct  cggggtcac  ggtcaagtt  tgttccgga  cggggagag  1380
atgggaacc  ttaaattta  tcaatttca  gacagcaga  aggtgaagg  cggcgaata  1440
aacgcggtg  ctgacacac  ggagatcat  aatgacacc  taaggttcc  ggggtccga  1500
ccacccaag  acaagacca  cattctgga  cagcttcgg  agatctcgc  tccactgta  1560
agcatcctg  ccgctctca  catcctcgg  atgatcatg  ccagcgcct  cctcttctt  1620
aacatcaag  accggaacc  aaagctgat  aagatgtca  gcccctaca  gaacaacct  1680
atcatcctg  gaggaatgc  gtcctatgc  tccatcttc  tctttggcc  cgatgggtc  1740
ttcgtctca  aaaagacct  tgaaacact  tgcacggtc  ggacctgga  tctcaccgt  1800
ggctacaca  ctgcctttg  ggccatgtt  gcaaagacc  ggagggtcc  tgccatctt  1860
aaaaatgtg  agatgaaga  gaagatcat  aaagaccag  agctgcttg  gattgtggg  1920
ggcatgctg  tcatcgacc  gtgcatcct  atctgttgg  aggctgtgg  ccccctgcg  1980
aggacagtg  agaggtaca  catggagcc  gacccagca  gccgggaca  ctccatccg  2040
ccattgctg  aacactgcg  aaacaccca  atgaccatc  ggcttggca  tgtctacgc  2100
tacaagggg  tcctcatgc  attcggttg  ttcttggca  gggaaaccc  caatgtgag  2160
atccctgcc  tcaacgaca  caagtacat  ggcatgagt  tgtacaatg  ggggatcat  2220
tgcatcatc  gggctgctg  ctccttcct  acgcgtgac  agcccaacg  gcagttctg  2280
atcgtggcc  tggtcatca  cttctgcag  accatcact  tctgcctgg  gtttgtgcc  2340
aagctcatc  ctctgagga  aaaccctga  gcagccact  agaacaggc  gttccagtt  2400
acacagaac  agaagaaag  agattcgaa  acctccact  cagtcacca  cgtgaacca  2460
gcgagcacg  cacgcctgg  gggactgca  tcagaaaac  accgccttc  aatgaagat  2520
acagagctg  acaaagact  ggaagaagt  accatgcag  tacaagaca  accagagaa  2580
accacatac  tcaaacaga  tcactacca  gagctcaac  acatcctca  cttgggcaa  2640
ttcacagag  gcacagatg  aggaaaggc  attctaaaa  atcacctcg  tcaaaaccc  2700
cagctccag  ggaacacga  agagccctc  agaacatgc  aagacccca  agaagacat  2760
aactccccg  agcacatcc  gcgccggct  tcgctccag  tccccatcc  tcaccacgc  2820
tacctccca  ccatcggag  cgtggatgc  agctgcgtc  gcccctgtg  cagccctac  2880
gccagccct  gccacagac  cgtaccacc  tccttccga  tcatggtct  gggcctgta  2940
gggtgggag  cctggggcc  gggcctccc  gggacagca  catgctggg  caaggcgcc  3000
gccacaggc  cactgacgg  ggcgagaag  tgggcacca  gctgcctct  cagactgct  3060
gaatggcgc  caggcagag  gggactcgg  accgacctc  agccttatc  gtgaaggtc  3120
tactctcac  gaggagagg  atgacaatg  cttctcctt  ttggcgtct  caaacaaag  3180
ggagttggg  tgtctgaaa  ttgcaaaaa  aaatcaaac  ctagacaaa  gagagaggc  3240
tcggactcc  gctgtcctc  ccaagtggc  agagcaagg  ctctgcag  3288



<210> 1333
<211> 940
<212> PRT
<213> Rattus norvegicus
<308> O88871
<400> 1333

Met Ala Ser Pro Pro Ser Ser Gly Gln Pro Arg Pro Pro Pro Pro Pro 
  1               5                  10                  15
Pro Pro Pro Ala Arg Leu Leu Leu Pro Leu Leu Leu Ser Leu Leu Leu 
             20                  25                  30
Trp Leu Ala Pro Gly Ala Trp Gly Trp Thr Arg Gly Ala Pro Arg Pro 
         35                  40                  45
Pro Pro Ser Ser Pro Pro Leu Ser Ile Met Gly Leu Met Pro Leu Thr 
     50                  55                  60
Lys Glu Val Ala Lys Gly Ser Ile Gly Arg Gly Val Leu Pro Ala Val 
 65                  70                  75                  80
Glu Leu Ala Ile Glu Gln Ile Arg Asn Glu Ser Leu Leu Arg Pro Tyr 
                 85                  90                  95
Phe Leu Asp Leu Arg Leu Tyr Asp Thr Glu Cys Asp Asn Ala Lys Gly 
             100                105                110
Leu Lys Ala Phe Tyr Asp Ala Ile Lys Tyr Gly Pro Asn His Leu Met 
         115                120                125
Val Phe Gly Gly Val Cys Pro Ser Val Thr Ser Ile Ile Ala Glu Ser 
     130                135                140
Leu Gln Gly Trp Asn Leu Val Gln Leu Ser Phe Ala Ala Thr Thr Pro 
 145                150                155                160
Val Leu Ala Asp Lys Lys Lys Tyr Pro Tyr Phe Phe Arg Thr Val Pro 
                 165                170                175
Ser Asp Asn Ala Val Asn Pro Ala Ile Leu Lys Leu Leu Lys His Phe 
             180                185                190
Arg Trp Arg Arg Val Gly Thr Leu Thr Gln Asp Val Gln Arg Phe Ser 
         195                200                205
Glu Val Arg Asn Asp Leu Thr Gly Val Leu Tyr Gly Glu Asp Ile Glu 
     210                215                220
Ile Ser Asp Thr Glu Ser Phe Ser Asn Asp Pro Cys Thr Ser Val Lys 
 225                230                235                240
Lys Leu Lys Gly Asn Asp Val Arg Ile Ile Leu Gly Gln Phe Asp Gln 
                 245                250                255
Asn Met Ala Ala Lys Val Phe Cys Cys Ala Phe Glu Glu Ser Met Phe 
             260                265                270
Gly Ser Lys Tyr Gln Trp Ile Ile Pro Gly Trp Tyr Glu Pro Ala Trp 
         275                280                285
Trp Glu Gln Val His Val Glu Ala Asn Ser Ser Arg Cys Leu Arg Arg 
     290                295                300
Ser Leu Leu Ala Ala Met Glu Gly Tyr Ile Gly Val Asp Phe Glu Pro 
 305                310                315                320
Leu Ser Ser Lys Gln Ile Lys Thr Ile Ser Gly Lys Thr Pro Gln Gln 
                 325                330                335
Phe Glu Arg Glu Tyr Asn Ser Lys Arg Ser Gly Val Gly Pro Ser Lys 
             340                345                350
Phe His Gly Tyr Ala Tyr Asp Gly Ile Trp Val Ile Ala Lys Thr Leu 
         355                360                365
Gln Arg Ala Met Glu Thr Leu His Ala Ser Ser Arg His Gln Arg Ile 
     370                375                380
Gln Asp Phe Asn Tyr Thr Asp His Thr Leu Gly Lys Ile Ile Leu Asn 
 385                390                395                400
Ala Met Asn Glu Thr Asn Phe Phe Gly Val Thr Gly Gln Val Val Phe 
                 405                410                415
Arg Asn Gly Glu Arg Met Gly Thr Ile Lys Phe Thr Gln Phe Gln Asp 
             420                425                430
Ser Arg Glu Val Lys Val Gly Glu Tyr Asn Ala Val Ala Asp Thr Leu 
         435                440                445
Glu Ile Ile Asn Asp Thr Ile Arg Phe Gln Gly Ser Glu Pro Pro Lys 
     450                455                460
Asp Lys Thr Ile Ile Leu Glu Gln Leu Arg Lys Ile Ser Leu Pro Leu 
 465                470                475                480
Tyr Ser Ile Leu Ser Ala Leu Thr Ile Leu Gly Met Ile Met Ala Ser 
                 485                490                495
Ala Phe Leu Phe Phe Asn Ile Lys Asn Arg Asn Gln Lys Leu Ile Lys 
             500                505                510
Met Ser Ser Pro Tyr Met Asn Asn Leu Ile Ile Leu Gly Gly Met Leu 
         515                520                525
Ser Tyr Ala Ser Ile Phe Leu Phe Gly Leu Asp Gly Ser Phe Val Ser 
     530                535                540
Glu Lys Thr Phe Glu Thr Leu Cys Thr Val Arg Thr Trp Ile Leu Thr 
 545                550                555                560
Val Gly Tyr Thr Thr Ala Phe Gly Ala Met Phe Ala Lys Thr Trp Arg 
                 565                570                575
Val His Ala Ile Phe Lys Asn Val Lys Met Lys Lys Lys Ile Ile Lys 
             580                585                590
Asp Gln Lys Leu Leu Val Ile Val Gly Gly Met Leu Leu Ile Asp Leu 
         595                600                605
Cys Ile Leu Ile Cys Trp Gln Ala Val Asp Pro Leu Arg Arg Thr Val 
     610                615                620
Glu Arg Tyr Ser Met Glu Pro Asp Pro Ala Gly Arg Asp Ile Ser Ile 
 625                630                635                640
Arg Pro Leu Leu Glu His Cys Glu Asn Thr His Met Thr Ile Trp Leu 
                 645                650                655
Gly Ile Val Tyr Ala Tyr Lys Gly Leu Leu Met Leu Phe Gly Cys Phe 
             660                665                670
Leu Ala Trp Glu Thr Arg Asn Val Ser Ile Pro Ala Leu Asn Asp Ser 
         675                680                685
Lys Tyr Ile Gly Met Ser Val Tyr Asn Val Gly Ile Met Cys Ile Ile 
     690                695                700
Gly Ala Ala Val Ser Phe Leu Thr Arg Asp Gln Pro Asn Val Gln Phe 
 705                710                715                720
Cys Ile Val Ala Leu Val Ile Ile Phe Cys Ser Thr Ile Thr Leu Cys 
                 725                730                735
Leu Val Phe Val Pro Lys Leu Ile Thr Leu Arg Thr Asn Pro Asp Ala 
             740                745                750
Ala Thr Gln Asn Arg Arg Phe Gln Phe Thr Gln Asn Gln Lys Lys Glu 
         755                760                765
Asp Ser Lys Thr Ser Thr Ser Val Thr Ser Val Asn Gln Ala Ser Thr 
     770                775                780
Ser Arg Leu Glu Gly Leu Gln Ser Glu Asn His Arg Leu Arg Met Lys 
 785                790                795                800
Ile Thr Glu Leu Asp Lys Asp Leu Glu Glu Val Thr Met Gln Leu Gln 
                 805                810                815
Asp Thr Pro Glu Lys Thr Thr Tyr Ile Lys Gln Asn His Tyr Gln Glu 
             820                825                830
Leu Asn Asp Ile Leu Ser Leu Gly Asn Phe Thr Glu Ser Thr Asp Gly 
         835                840                845
Gly Lys Ala Ile Leu Lys Asn His Leu Asp Gln Asn Pro Gln Leu Gln 
     850                855                860
Trp Asn Thr Thr Glu Pro Ser Arg Thr Cys Lys Asp Pro Ile Glu Asp 
 865                870                875                880
Ile Asn Ser Pro Glu His Ile Gln Arg Arg Leu Ser Leu Gln Leu Pro 
                 885                890                895
Ile Leu His His Ala Tyr Leu Pro Ser Ile Gly Gly Val Asp Ala Ser 
             900                905                910
Cys Val Ser Pro Cys Val Ser Pro Thr Ala Ser Pro Arg His Arg His 
         915                920                925
Val Pro Pro Ser Phe Arg Val Met Val Ser Gly Leu 
     930                935                940



<210> 1334
<211> 465
<212> DNA
<213> Homo sapiens
<308> AB015334
<400> 1334

gacgcgtgg  ccagcgtcg  ctgtccctc  agctcccca  cctccacca  gcctacctc  60
catccatcg  aggcgtgga  gccagctgt  tcagcccct  cgtcagccc  accgccagc  120
cccgccaca  acatgtgcc  ccctccttc  gagtcatgg  ctcgggcct  taagggtgg  180
aggcctggg  ccggggcct  ccccgtgac  gaaccacac  gggcagagg  gtctgctgc  240
gaaacactg  cggctctgg  tgcggagaa  ctgggcacc  tggctggcc  ctcaggacc  300
ctcggatgg  actcaggtg  acaggacgg  gcaggggga  acttggcac  tgacctcga  360
ccttatttg  gaagtcctt  tttcttcac  aagaagagg  acggaaatg  gacgtcttc  420
ttaacatct  caaacaagg  ggcgctggg  tatcaaact  gcaat  465



<210> 1335
<211> 941
<212> PRT
<213> Homo sapiens
<308> O75899
<400> 1335

Met Ala Ser Pro Arg Ser Ser Gly Gln Pro Gly Pro Pro Pro Pro Pro 
  1               5                  10                  15
Pro Pro Pro Pro Ala Arg Leu Leu Leu Leu Leu Leu Leu Pro Leu Leu 
             20                  25                  30
Leu Pro Leu Ala Pro Gly Ala Trp Gly Trp Ala Arg Gly Ala Pro Arg 
         35                  40                  45
Pro Pro Pro Ser Ser Pro Pro Leu Ser Ile Met Gly Leu Met Pro Leu 
     50                  55                  60
Thr Lys Glu Val Ala Lys Gly Ser Ile Gly Arg Gly Val Leu Pro Ala 
 65                  70                  75                  80
Val Glu Leu Ala Ile Glu Gln Ile Arg Asn Glu Ser Leu Leu Arg Pro 
                 85                  90                  95
Tyr Phe Leu Asp Leu Arg Leu Tyr Asp Thr Glu Cys Asp Asn Ala Lys 
             100                105                110
Gly Leu Lys Ala Phe Tyr Asp Ala Ile Lys Tyr Gly Pro Asn His Leu 
         115                120                125
Met Val Phe Gly Gly Val Cys Pro Ser Val Thr Ser Ile Ile Ala Glu 
     130                135                140
Ser Leu Gln Gly Trp Asn Leu Val Gln Leu Ser Phe Ala Ala Thr Thr 
 145                150                155                160
Pro Val Leu Ala Asp Lys Lys Lys Tyr Pro Tyr Phe Phe Arg Thr Val 
                 165                170                175
Pro Ser Asp Asn Ala Val Asn Pro Ala Ile Leu Lys Leu Leu Lys His 
             180                185                190
Tyr Gln Trp Lys Arg Val Gly Thr Leu Thr Gln Asp Val Gln Arg Phe 
         195                200                205
Ser Glu Val Arg Asn Asp Leu Thr Gly Val Leu Tyr Gly Glu Asp Ile 
     210                215                220
Glu Ile Ser Asp Thr Glu Ser Phe Ser Asn Asp Pro Cys Thr Ser Val 
 225                230                235                240
Lys Lys Leu Lys Gly Asn Asp Val Arg Ile Ile Leu Gly Gln Phe Asp 
                 245                250                255
Gln Asn Met Ala Ala Lys Val Phe Cys Cys Ala Tyr Glu Glu Asn Met 
             260                265                270
Tyr Gly Ser Lys Tyr Gln Trp Ile Ile Pro Gly Trp Tyr Glu Pro Ser 
         275                280                285
Trp Trp Glu Gln Val His Thr Glu Ala Asn Ser Ser Arg Cys Leu Arg 
     290                295                300
Lys Asn Leu Leu Ala Ala Met Glu Gly Tyr Ile Gly Val Asp Phe Glu 
 305                310                315                320
Pro Leu Ser Ser Lys Gln Ile Lys Thr Ile Ser Gly Lys Thr Pro Gln 
                 325                330                335
Gln Tyr Glu Arg Glu Tyr Asn Asn Lys Arg Ser Gly Val Gly Pro Ser 
             340                345                350
Lys Phe His Gly Tyr Ala Tyr Asp Gly Ile Trp Val Ile Ala Lys Thr 
         355                360                365
Leu Gln Arg Ala Met Glu Thr Leu His Ala Ser Ser Arg His Gln Arg 
     370                375                380
Ile Gln Asp Phe Asn Tyr Thr Asp His Thr Leu Gly Arg Ile Ile Leu 
 385                390                395                400
Asn Ala Met Asn Glu Thr Asn Phe Phe Gly Val Thr Gly Gln Val Val 
                 405                410                415
Phe Arg Asn Gly Glu Arg Met Gly Thr Ile Lys Phe Thr Gln Phe Gln 
             420                425                430
Asp Ser Arg Glu Val Lys Val Gly Glu Tyr Asn Ala Val Ala Asp Thr 
         435                440                445
Leu Glu Ile Ile Asn Asp Thr Ile Arg Phe Gln Gly Ser Glu Pro Pro 
     450                455                460
Lys Asp Lys Thr Ile Ile Leu Glu Gln Leu Arg Lys Ile Ser Leu Pro 
 465                470                475                480
Leu Tyr Ser Ile Leu Ser Ala Leu Thr Ile Leu Gly Met Ile Met Ala 
                 485                490                495
Ser Ala Phe Leu Phe Phe Asn Ile Lys Asn Arg Asn Gln Lys Leu Ile 
             500                505                510
Lys Met Ser Ser Pro Tyr Met Asn Asn Leu Ile Ile Leu Gly Gly Met 
         515                520                525
Leu Ser Tyr Ala Ser Ile Phe Leu Phe Gly Leu Asp Gly Ser Phe Val 
     530                535                540
Ser Glu Lys Thr Phe Glu Thr Leu Cys Thr Val Arg Thr Trp Ile Leu 
 545                550                555                560
Thr Val Gly Tyr Thr Thr Ala Phe Gly Ala Met Phe Ala Lys Thr Trp 
                 565                570                575
Arg Val His Ala Ile Phe Lys Asn Val Lys Met Lys Lys Lys Ile Ile 
             580                585                590
Lys Asp Gln Lys Leu Leu Val Ile Val Gly Gly Met Leu Leu Ile Asp 
         595                600                605
Leu Cys Ile Leu Ile Cys Trp Gln Ala Val Asp Pro Leu Arg Arg Thr 
     610                615                620
Val Glu Lys Tyr Ser Met Glu Pro Asp Pro Ala Gly Arg Asp Ile Ser 
 625                630                635                640
Ile Arg Pro Leu Leu Glu His Cys Glu Asn Thr His Met Thr Ile Trp 
                 645                650                655
Leu Gly Ile Val Tyr Ala Tyr Lys Gly Leu Leu Met Leu Phe Gly Cys 
             660                665                670
Phe Leu Ala Trp Glu Thr Arg Asn Val Ser Ile Pro Ala Leu Asn Asp 
         675                680                685
Ser Lys Tyr Ile Gly Met Ser Val Tyr Asn Val Gly Ile Met Cys Ile 
     690                695                700
Ile Gly Ala Ala Val Ser Phe Leu Thr Arg Asp Gln Pro Asn Val Gln 
 705                710                715                720
Phe Cys Ile Val Ala Leu Val Ile Ile Phe Cys Ser Thr Ile Thr Leu 
                 725                730                735
Cys Leu Val Phe Val Pro Lys Leu Ile Thr Leu Arg Thr Asn Pro Asp 
             740                745                750
Ala Ala Thr Gln Asn Arg Arg Phe Gln Phe Thr Gln Asn Gln Lys Lys 
         755                760                765
Glu Asp Ser Lys Thr Ser Thr Ser Val Thr Ser Val Asn Gln Ala Ser 
     770                775                780
Thr Ser Arg Leu Glu Gly Leu Gln Ser Glu Asn His Arg Leu Arg Met 
 785                790                795                800
Lys Ile Thr Glu Leu Asp Lys Asp Leu Glu Glu Val Thr Met Gln Leu 
                 805                810                815
Gln Asp Thr Pro Glu Lys Thr Thr Tyr Ile Lys Gln Asn His Tyr Gln 
             820                825                830
Glu Leu Asn Asp Ile Leu Asn Leu Gly Asn Phe Thr Glu Ser Thr Asp 
         835                840                845
Gly Gly Lys Ala Ile Leu Lys Asn His Leu Asp Gln Asn Pro Gln Leu 
     850                855                860
Gln Trp Asn Thr Thr Glu Pro Ser Arg Thr Cys Lys Asp Pro Ile Glu 
 865                870                875                880
Asp Ile Asn Ser Pro Glu His Ile Gln Arg Arg Leu Ser Leu Gln Leu 
                 885                890                895
Pro Ile Leu His His Ala Tyr Leu Pro Ser Ile Gly Gly Val Asp Ala 
             900                905                910
Ser Cys Val Ser Pro Cys Val Ser Pro Thr Ala Ser Pro Arg His Arg 
         915                920                925
His Val Pro Pro Ser Phe Arg Val Met Val Ser Gly Leu 
     930                935                940



<210> 1336
<211> 2597
<212> DNA
<213> Rattus norvegicus
<308> AJ000556
<400> 1336

cattctcca  agaagcaga  aaatggcta  gagaagaaa  gggttccag  agcaacccc  60
ctccttgat  ccagttcac  ggagtatct  tttgcgcag  gacagtatg  tttgatcaa  120
tgcctggct  ccattcggg  ccccaagac  gagcaagat  gacatgata  tgagaatga  180
tgcctgggc  tggctgtcc  ggccatctc  cactatgcc  tgatgaaga  gatgcagtt  240
ccagagctt  ccaaagaca  cagctacaa  cgatatatt  cagaaacat  gaataaatc  300
atcagacag  ggaatcttc  taccaggat  cgaataaat  atgttttca  ggatttctt  360
aaggaattt  acaacaaga  catctgtga  agcagtgtg  ctacacacg  cctgaaggt  420
aagtacctg  ctaccttgg  aaccttaac  aagcattat  gagccgaga  atttgagac  480
tctatgctc  tgatttcat  agaaaatga  ccgagtcgg  gccattcca  cgacagtgg  540
aatgttctc  atgaagtca  ggtaacagg  aatctcggg  tccagtggc  gcagaaacc  600
aatgttctt  ctgttgaaa  ggaaaaaaa  aaactgaag  ggaaaaaac  ggactatat  660
aaacacaag  aggaggatg  cagaaacaa  ctccgggaa  agtggaaca  tttttccta  720
ttccccgag  ttacccaca  tgttatcaa  gagtctgtg  tcagcatta  caaacagga  780
aacaagaac  tggaactaa  gctctcttc  catgaggga  ccttgtcct  cgtgtccct  840
gtagatggc  acttccggc  cactgcaga  gctcaccat  acctctgta  tgatgtggc  900
cccccgctg  ttgtccaca  catacagaa  ggctgtcac  gtccaatct  cacagatat  960
gcattcaat  agctgcggc  ggaggggag  gaggagggg  tgtacgtgc  gaggtggag  1020
tgcaccgac  ttgacaaca  tcttattgc  gtcagctgc  tcgaaaagt  cgaggtatt  1080
ggtaatcag  agcagttca  gaactttca  attgaggtg  agaagggcc  ctacagcct  1140
catggctct  ttgaccact  tcccagcct  agagacctc  tgaaccacc  caagaagca  1200
atcctgcgc  cggacaata  aagctttgt  ctgaaacgc  gctgtcagt  taagcctcg  1260
gaaatctcc  acctactag  agccactaa  aaagcccag  agtggcagc  tgtctactc  1320
atgagccag  tgagtttcg  tcggatcct  aagaaagat  ttatccaag  tgagcacct  1380
ggcagaggc  caagaacac  tatctattc  gggaccctg  tggattaca  ggacgatga  1440
ggaattgct  aagaaaaga  gataaaagt  attctcaaa  tcctagacc  tagccaccg  1500
gacatttca  tggccttct  tgaggcagc  agcatgatg  gacaggttt  ccacaaaca  1560
atcgtgtac  tctacggcg  ctgtgtccg  gatgtagaa  atatcatgg  ggaagagtt  1620
gtggagggg  ggccattgg  tctcttcat  caccggaaa  gtgatgcac  tactacccc  1680
tggaagttt  aagttgcca  acagctggc  agcgccctg  gttacttgg  agataaaga  1740
ctcgttcat  gaaatgtgt  cactaaaaa  ctcctcctg  cccgtgagg  cattgacag  1800
gacattggc  cgttcatca  gcttagtga  cttggcatc  cagtctctg  gctgaccag  1860
caagagtgc  tagagcgaa  tccctggat  gctcctgag  gtgttgaag  ctccaagaa  1920
ctgagtgtg  ctgctgaca  gtggagctt  ggaaccaca  tctgggaaa  ccgctacga  1980
ggcgagatc  cactcaagg  caagaccct  attgagaaa  agaggtttt  tgaaagccg  2040
tgcaggcca  tgacaccat  ttgcaagga  ctagctgac  tcatgactc  ctgcatgaa  2100
tatgatccc  accagagac  tttcttccg  gccatcatg  gggacatta  caagctgga  2160
gagcagaat  cagacattg  ttcagaaaa  cacccaata  cagaggtgg  tcccactca  2220
tttgaaaag  gtttcctaa  gaggattcg  gacttggga  agggtcact  tgggaaggt  2280
gagctctgc  gatatgatc  tgagggaga  aacacaggg  aacaggtag  tgtcaagtc  2340
ctgaagcct  agagtggag  taaccacat  gctgatctg  agaaggaga  agagatctt  2400
cggaacctc  accacgaga  cattgtgaa  tataaagga  tctgcatgg  agacggggg  2460
aatggtatc  agctcatca  ggagtttct  ccttcggga  gcctaaagg  atatctgcc  2520
aagaataag  acaaaatca  cctcaaaca  cagctaaaa  atgccatcc  gatttgtaa  2580
gggatggac  atctggg  2597



<210> 1337
<211> 866
<212> PRT
<213> Rattus norvegicus
<308> CAA04187
<400> 1337

His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Arg Val Pro 
  1               5                  10                  15
Glu Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
             20                  25                  30
Gln Gly Gln Tyr Asp Leu Ile Lys Cys Leu Ala Pro Ile Arg Asp Pro 
         35                  40                  45
Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
     50                  55                  60
Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
 65                  70                  75                  80
Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 
                 85                  90                  95
Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 
             100                105                110
Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 
         115                120                125
Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 
     130                135                140
Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 
 145                150                155                160
Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Pro Ser Arg Cys His Ser 
                 165                170                175
Asn Asp Ser Gly Asn Val Leu Tyr Glu Val Met Val Thr Gly Asn Leu 
             180                185                190
Gly Ile Gln Trp Arg Gln Lys Pro Asn Val Leu Pro Val Glu Lys Glu 
         195                200                205
Lys Asn Lys Leu Lys Arg Lys Lys Leu Asp Tyr Ile Lys His Lys Lys 
     210                215                220
Glu Asp Ala Arg Asn Lys Leu Arg Glu Glu Trp Asn Ser Phe Ser Tyr 
 225                230                235                240
Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile 
                 245                250                255
Asn Lys Gln Asp Asn Lys Asn Met Glu Leu Lys Leu Ser Ser His Glu 
             260                265                270
Gly Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr 
         275                280                285
Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile 
     290                295                300
Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile Cys Thr Asp Ile 
 305                310                315                320
Ala Phe Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val 
                 325                330                335
Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu Ile Ala Val Ser 
             340                345                350
Cys Phe Glu Lys Ser Glu Val Leu Gly Asn Gln Lys Gln Phe Lys Asn 
         355                360                365
Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser Val 
     370                375                380
Asp His Phe Pro Ser Leu Arg Asp Leu Met Asn His Leu Lys Lys Gln 
 385                390                395                400
Ile Leu Arg Thr Asp Asn Ile Ser Phe Val Leu Lys Arg Cys Cys Gln 
                 405                410                415
Ser Lys Pro Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys Ala 
             420                425                430
Gln Glu Trp Gln Pro Val Tyr Ser Met Ser Gln Leu Ser Phe Asp Arg 
         435                440                445
Ile Leu Lys Lys Asp Ile Ile Gln Gly Glu His Leu Gly Arg Gly Thr 
     450                455                460
Arg Thr His Ile Tyr Ser Gly Thr Leu Leu Asp Tyr Lys Asp Asp Glu 
 465                470                475                480
Gly Ile Ala Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu Asp 
                 485                490                495
Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser Met 
             500                505                510
Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val Cys 
         515                520                525
Val Arg Asp Val Glu Asn Ile Met Val Glu Glu Phe Val Glu Gly Gly 
     530                535                540
Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp Ala Leu Thr Thr Pro 
 545                550                555                560
Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser Ala Leu Ser Tyr Leu 
                 565                570                575
Glu Asp Lys Asp Leu Val His Gly Asn Val Cys Thr Lys Asn Leu Leu 
             580                585                590
Leu Ala Arg Glu Gly Ile Asp Ser Asp Ile Gly Pro Phe Ile Lys Leu 
         595                600                605
Ser Asp Leu Gly Ile Pro Val Ser Val Leu Thr Arg Gln Glu Cys Ile 
     610                615                620
Glu Arg Asn Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser Lys Asn 
 625                630                635                640
Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly Thr Thr Leu Trp Glu 
                 645                650                655
Ile Arg Tyr Asp Gly Glu Ile Pro Leu Lys Asp Lys Thr Leu Ile Glu 
             660                665                670
Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro Val Thr Pro Ser Cys 
         675                680                685
Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met Asn Tyr Asp Pro Asn 
     690                695                700
Gln Arg Pro Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu Glu 
 705                710                715                720
Glu Gln Asn Pro Asp Ile Val Ser Glu Lys His Pro Ile Thr Glu Val 
                 725                730                735
Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg Asp Leu 
             740                745                750
Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg Tyr Asp Pro Glu 
         755                760                765
Gly Asp Asn Thr Gly Glu Gln Val Ala Val Lys Ser Leu Lys Pro Glu 
     770                775                780
Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys Glu Ile Glu Ile Leu 
 785                790                795                800
Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr Lys Gly Ile Cys Met 
                 805                810                815
Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met Glu Phe Leu Pro Ser 
             820                825                830
Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn Leu 
         835                840                845
Lys Gln Gln Leu Lys Tyr Ala Ile Gln Ile Cys Lys Gly Met Asp Tyr 
     850                855                860
Leu Gly 
 865



<210> 1338
<211> 3030
<212> DNA
<213> Rattus norvegicus
<308> AJ001029
<400> 1338

cggacacta  actgtagag  tgagaccaa  gataggagc  ctcgggcaa  gggaggaag  60
acatagaat  gccttgaag  gcagaaaag  gggaggggg  cttttctca  tggggaaga  120
tgactgagg  acttcacta  atccagggc  gagaccctt  cccaggaga  gaagagctc  180
gcatggaag  gagacccct  cccccaacc  aatgtcctc  tcacccttc  tgaagagta  240
ccactcccc  ccccctcct  ccttcccca  ccgtctgca  cggctcagt  gctcagtca  300
tctcgggct  tccagccag  gtgtttggt  gtgaggatt  aggctccgt  cagacaagg  360
agtggcctg  ggctcaggg  cccccagcc  ctccctccc  gtccatcag  gtcactccc  420
agccccgag  tggaccgca  accttggga  acggttttc  acttcctca  gacgagccc  480
agactggag  agaggtcgg  ggaggtggg  gttgggctc  tcacgagga  cccggcggc  540
ggcccgggg  aggcggccg  agcggcggc  gccgggagc  acatggccg  ggagcaaga  600
ctatcagag  tggagctga  ccccgtggg  tcggaggaa  ctcgctgcc  gtccccaag  660
agcgcgccg  cgctgggac  cgacggcgg  ggcggtggc  caggcctgc  agccagccc  720
gggcccggc  aattgggca  ggtcaagaa  gaacagcag  acggcgagg  agacgatga  780
aagttcccg  tgtgcatcc  cgaggcggt  agccaggtg  tcagcggct  cgactggac  840
ctggtgccc  tgcccgtgc  ggtcaacgg  gccagcaag  gcaagccgc  cgtcaaacg  900
cccatgaac  cctttatgg  gtgggcaca  gcggcacgc  gaaagttag  cgaccagta  960
ccgcacctc  acaatgctg  gctcagcaa  acgctgggc  agctctgga  gttgctgaa  1020
gagagtgac  agcgcccct  cattgagga  gccgagcgg  tccggatgc  gcacaaaaa  1080
gaccatccg  actacaagt  ccaacctcg  cggcggaag  atgggaagg  agcccaggg  1140
gaggcagag  gcccaggcg  ggagaccga  caaggaggg  ctgctgcta  ccaggctca  1200
tacaagagt  cccacctgg  ccaccggca  ccagaagaa  gctccccca  gtcagatgg  1260
aacccagag  acccctcag  ccagagcca  ggccctcct  cccctccaa  caccccaaa  1320
acagagctg  agtccggca  ggcagatcc  aaaagggat  ggcgctcct  gggggaggg  1380
gggaagccc  acatcgact  cggcaatgt  gacatcggg  agatcagcc  tgaggtaat  1440
tccaacatg  agacctttg  tgtgactga  ctggaccaa  acctgccgc  caatgggca  1500
ccaggccac  tgggcagct  ctcggcagc  ggctacggg  tgagcagtg  cctggctgt  1560
gccagtgga  actctgcct  gatctccaa  ccaccaggt  tggctctgc  cacggtctc  1620
ccccctgct  tggatgcca  agcccaggt  aagacagag  ccacagggc  ccagggacc  1680
ccacactac  ccgaccagc  gtccacttc  cagatcgcc  acacctccc  cagtctgcc  1740
cactacggc  ccgccttcc  ctccatctc  cgcccccag  ttgactact  tgaccatca  1800
ccctcagga  cctattatg  ccacgcagg  caggcctct  gcctctact  agctttttc  1860
tacatgggc  cctctcagc  gcccctcta  acggccatc  ctgacccca  cccctcagg  1920
ccccagtcc  acagtccca  acactggga  cagccagta  atacgactc  atcccgacc  1980
tagaggggc  ctgtcacca  tggtgccca  gtggcccag  gccccttcc  ccagcctgt  2040
tgccctgct  ctcatcagc  tcatgccca  cagtggcag  ggaggaggc  gcagaggct  2100
acagcagca  gcaggcttc  gccagctcc  gccctgatg  cctccaccc  ccctggctc  2160
ggaggccaa  ccctgactg  gctggcaaa  gaggagttt  gtggccatc  cagactgag  2220
gtgaggggc  acccatccc  agaaataac  ctctatccc  ggacctgag  agtcgttct  2280
aagtctttc  gggaggcag  aaagggtat  gtgggaaac  tcactgctc  tgttctctc  2340
tgggagagc  aggggctca  gggcctgtg  gccactgtg  cactgtgcc  aaaagctag  2400
ctgcctagg  acctgcttc  aagcctgga  ctggctctg  cctgtcact  aggactcac  2460
gaggacagc  ttgaacagc  ttgtgaaga  cagggtggg  cactcaatg  acactctga  2520
cctttcacc  ccctcctca  ctgaatggg  actggccga  gtccccaga  ccagttctg  2580
attagtaac  tcatccctc  cctaactga  gagagtcct  atgttcttc  ccacgacct  2640
cactcctca  ggcccaccc  aggtgagga  gcaggggct  caggaaaga  tcagaggtg  2700
ccagccttc  tctcgcctt  tgtcagcct  agttagcac  gcacgggcc  tagccccag  2760
gcccagtac  tgggttgct  gcagcaggc  ggacactaa  ccccttcca  gtacagtct  2820
cctttgcct  gcacccttt  ctccagcga  atcttaata  agtacgtag  tctgtctcc  2880
catctcctg  ctgcagccc  gtccacacg  aacacatcg  tgccccttt  tctccacag  2940
caccatgtt  ccatccctc  agctactcc  gccccaatt  acttgcatt  agcactcca  3000
gtaataaaa  caaagcttc  ggttgcctgc  3030



<210> 1339
<211> 466
<212> PRT
<213> Rattus norvegicus
<308> O55170
<400> 1339

Met Ala Glu Glu Gln Asp Leu Ser Glu Val Glu Leu Ser Pro Val Gly 
  1               5                  10                  15
Ser Glu Glu Pro Arg Cys Leu Ser Pro Ser Ser Ala Pro Ser Leu Gly 
             20                  25                  30
Pro Asp Gly Gly Gly Gly Gly Ser Gly Leu Arg Ala Ser Pro Gly Pro 
         35                  40                  45
Gly Glu Leu Gly Lys Val Lys Lys Glu Gln Gln Asp Gly Glu Ala Asp 
     50                  55                  60
Asp Asp Lys Phe Pro Val Cys Ile Arg Glu Ala Val Ser Gln Val Leu 
 65                  70                  75                  80
Ser Gly Tyr Asp Trp Thr Leu Val Pro Met Pro Val Arg Val Asn Gly 
                 85                  90                  95
Ala Ser Lys Ser Lys Pro His Val Lys Arg Pro Met Asn Ala Phe Met 
             100                105                110
Val Trp Ala Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro His 
         115                120                125
Leu His Asn Ala Glu Leu Ser Lys Thr Leu Gly Lys Leu Trp Arg Leu 
     130                135                140
Leu Asn Glu Ser Asp Lys Arg Pro Phe Ile Glu Glu Ala Glu Arg Leu 
 145                150                155                160
Arg Met Gln His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro Arg 
                 165                170                175
Arg Arg Lys Asn Gly Lys Ala Ala Gln Gly Glu Ala Glu Cys Pro Gly 
             180                185                190
Gly Glu Thr Asp Gln Gly Gly Ala Ala Ala Ile Gln Ala His Tyr Lys 
         195                200                205
Ser Ala His Leu Asp His Arg His Pro Glu Glu Gly Ser Pro Met Ser 
     210                215                220
Asp Gly Asn Pro Glu His Pro Ser Gly Gln Ser His Gly Pro Pro Thr 
 225                230                235                240
Pro Pro Thr Thr Pro Lys Thr Glu Leu Gln Ser Gly Lys Ala Asp Pro 
                 245                250                255
Lys Arg Asp Gly Arg Ser Leu Gly Glu Gly Gly Lys Pro His Ile Asp 
             260                265                270
Phe Gly Asn Val Asp Ile Gly Glu Ile Ser His Glu Val Met Ser Asn 
         275                280                285
Met Glu Thr Phe Asp Val Thr Glu Leu Asp Gln Tyr Leu Pro Pro Asn 
     290                295                300
Gly His Pro Gly His Val Gly Ser Tyr Ser Ala Ala Gly Tyr Gly Leu 
 305                310                315                320
Ser Ser Ala Leu Ala Val Ala Ser Gly His Ser Ala Trp Ile Ser Lys 
                 325                330                335
Pro Pro Gly Val Ala Leu Pro Thr Val Ser Pro Pro Ala Val Asp Ala 
             340                345                350
Lys Ala Gln Val Lys Thr Glu Thr Thr Gly Pro Gln Gly Pro Pro His 
         355                360                365
Tyr Thr Asp Gln Pro Ser Thr Ser Gln Ile Ala Tyr Thr Ser Leu Ser 
     370                375                380
Leu Pro His Tyr Gly Ser Ala Phe Pro Ser Ile Ser Arg Pro Gln Phe 
 385                390                395                400
Asp Tyr Ser Asp His Gln Pro Ser Gly Pro Tyr Tyr Gly His Ala Gly 
                 405                410                415
Gln Ala Ser Gly Leu Tyr Ser Ala Phe Ser Tyr Met Gly Pro Ser Gln 
             420                425                430
Arg Pro Leu Tyr Thr Ala Ile Ser Asp Pro Ser Pro Ser Gly Pro Gln 
         435                440                445
Ser His Ser Pro Thr His Trp Glu Gln Pro Val Tyr Thr Thr Leu Ser 
     450                455                460
Arg Pro 
 465



<210> 1340
<211> 2882
<212> DNA
<213> Homo sapiens
<308> BC007595
<400> 1340

gtccggcca  ggtggttgg  ggtaaggat  caggctccg  cctaacgag  ccgtggcct  60
aggctcagg  ccccccgcc  ctccctccc  gcccaccag  gtcacctcc  agccccgag  120
tggaccgca  accttggga  acggttttc  acttcctaa  gacgagccc  agactggag  180
agaggtccg  ggaggtggg  gttggactc  ttgcgagga  cccggcggc  ggcccgggg  240
aggcggccg  ggcggcggc  gcggcggcc  ggggcgaca  ggcggagga  caggaccta  300
cggaggtgg  gctgagccc  gtgggctcg  aggagcccc  ctgcctgtc  ccggggagc  360
cgccctcgc  agggcccga  ggcggcggc  gcggatcgg  cctgcgagc  agcccgggg  420
caggcgagc  gggcaaggt  aagaaggag  agcaggacg  cgaggcgga  gatgacaag  480
tccccgtgt  catccgcga  gccgtcagc  aggtgctca  cggctacga  tggacgctg  540
tgcccatgc  cgtgcgcgt  aacggcgcc  gcaaaagca  gccgcacgt  aagcggccc  600
tgaacgcct  catggtgtg  gctcaggca  cgcgcagga  gctcgcgga  cagtacccg  660
acctgcaca  cgctgagct  agcaagacg  tgggcaagc  ctggaggct  ctgaacgaa  720
gtgacaagc  ccccttcat  gaggaggct  agcggctcc  tatgcagca  aagaaagac  780
acccggact  caagtacca  cccaggcgg  ggaagaacg  gaaggccgc  cagggcgag  840
cggagtgcc  cggtgggga  gccgagcaa  gtgggaccg  cgccatcca  gcccactac  900
agagcgccc  cttggacca  cggcaccca  gagagggct  ccccatgtc  gatggtaac  960
ccgagcacc  ctcaggcca  agccatggc  cacccaccc  tccaaccac  ccgaagaca  1020
agctgcagt  gggcaaggc  gacccgaag  gggacgggc  ctccatggg  gagggcggg  1080
agcctcaca  cgacttcgg  aacgtggac  ttggtgaga  cagccacga  gtaatgtcc  1140
acatggaga  ctttgatgt  gctgagttg  accagtacc  gccgcccaa  gggcaccca  1200
gccatgtga  cagctactc  gcagccggc  atgggctgg  cagtgccct  gccgtggcc  1260
gtggacact  cgcctggat  tccaagcca  caggcgtgg  tctgcccac  gtctcacca  1320
ctggtgtgg  tgccaaagc  caggtgaag  cagagaccg  ggggcccca  gggccccca  1380
actacaccg  ccagccatc  acctcacag  tcgcctaca  ctccctcag  ctgccccac  1440
atggctcag  cttcccctc  atctcccgc  cccagtttg  ctactctga  catcagccc  1500
caggaccct  ttatggcca  tcgggccag  cctctggcc  ctactcggc  ttctcctat  1560
tggggccct  gcagcggcc  ctctacacg  ccatctctg  ccccagccc  tcagggccc  1620
agtcccaca  ccccacaca  tgggagcag  cagtatata  gacactgtc  cggccctaa  1680
gggggccct  tcgccacca  cccccgccc  gcccctgcc  ccagcctgt  tgccctgtt  1740
cttgcccac  tcaggcctg  tggtggcag  ggaggaggc  gaggaggct  aagaggctg  1800
caggtcggg  ggctttctg  ctggctcac  gccctgatg  cccacccgc  ccatccagg  1860
tccagcagc  aagccccag  agaacaggc  ggacagagg  gaaggaggt  gactgttgc  1920
cccacactg  aagatgagg  gctgcacct  cccccagga  tgaccctct  tcccaggac  1980
tgagaaggg  ctgctcacc  tcctcgggg  ggggaagca  cagggttgg  ggcatcgga  2040
gccttacca  tcctatgac  cctgttttc  ctctcacag  tagtgaggg  ctgacatgc  2100
catgccacc  atgccacag  gcctaaggg  taggccacc  agagactgt  cccggagct  2160
gccgtgtct  ccactcagg  gctgagagt  gctttgagg  gcctcattg  ggagtgggg  2220
gttcgaggg  cttagtgga  ttctcatcc  ttcaatgcc  cctcccttt  tgaaggcag  2280
aaggagttg  cacagaggc  ccctgatcc  attctgtgc  aataacctc  ttctttgtc  2340
gagaaacag  ccccagtcc  cctccacta  aacctccat  accttgaga  gcatcccag  2400
aggtgacga  gcaggggct  caggaaagg  atcagagac  attcacaga  cctccctcc  2460
tgggctcct  gccagctcc  tcttccctt  ctaggctct  tggcccctg  tcagtcagc  2520
ccactccct  ggcttccca  agagtgaca  ctgctcagg  cctaaccct  ggctccagg  2580
gacacaggg  ccagcaccc  ggttgctgt  ggcaggctg  agacactag  atcctgacc  2640
gtacattct  cccttgcct  ttacccctt  cctcccagt  gtatttgaa  aaagtatgt  2700
gctatatct  cccctattt  cctgttctg  agcccccca  atccacatg  aactcatta  2760
tgtctcctg  tatttatct  agtagtccc  tctcctagc  actctagcc  ctattaact  2820
tgcattaag  attccacat  ataaaatta  aggttccgg  taaaaaaaa  aaaaaaaaa  2880
aa  2882



<210> 1341
<211> 466
<212> PRT
<213> Homo sapiens
<308> P56693
<400> 1341

Met Ala Glu Glu Gln Asp Leu Ser Glu Val Glu Leu Ser Pro Val Gly 
  1               5                  10                  15
Ser Glu Glu Pro Arg Cys Leu Ser Pro Gly Ser Ala Pro Ser Leu Gly 
             20                  25                  30
Pro Asp Gly Gly Gly Gly Gly Ser Gly Leu Arg Ala Ser Pro Gly Pro 
         35                  40                  45
Gly Glu Leu Gly Lys Val Lys Lys Glu Gln Gln Asp Gly Glu Ala Asp 
     50                  55                  60
Asp Asp Lys Phe Pro Val Cys Ile Arg Glu Ala Val Ser Gln Val Leu 
 65                  70                  75                  80
Ser Gly Tyr Asp Trp Thr Leu Val Pro Met Pro Val Arg Val Asn Gly 
                 85                  90                  95
Ala Ser Lys Ser Lys Pro His Val Lys Arg Pro Met Asn Ala Phe Met 
             100                105                110
Val Trp Ala Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro His 
         115                120                125
Leu His Asn Ala Glu Leu Ser Lys Thr Leu Gly Lys Leu Trp Arg Leu 
     130                135                140
Leu Asn Glu Ser Asp Lys Arg Pro Phe Ile Glu Glu Ala Glu Arg Leu 
 145                150                155                160
Arg Met Gln His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro Arg 
                 165                170                175
Arg Arg Lys Asn Gly Lys Ala Ala Gln Gly Glu Ala Glu Cys Pro Gly 
             180                185                190
Gly Glu Ala Glu Gln Gly Gly Thr Ala Ala Ile Gln Ala His Tyr Lys 
         195                200                205
Ser Ala His Leu Asp His Arg His Pro Gly Glu Gly Ser Pro Met Ser 
     210                215                220
Asp Gly Asn Pro Glu His Pro Ser Gly Gln Ser His Gly Pro Pro Thr 
 225                230                235                240
Pro Pro Thr Thr Pro Lys Thr Glu Leu Gln Ser Gly Lys Ala Asp Pro 
                 245                250                255
Lys Arg Asp Gly Arg Ser Met Gly Glu Gly Gly Lys Pro His Ile Asp 
             260                265                270
Phe Gly Asn Val Asp Ile Gly Glu Ile Ser His Glu Val Met Ser Asn 
         275                280                285
Met Glu Thr Phe Asp Val Ala Glu Leu Asp Gln Tyr Leu Pro Pro Asn 
     290                295                300
Gly His Pro Gly His Val Ser Ser Tyr Ser Ala Ala Gly Tyr Gly Leu 
 305                310                315                320
Gly Ser Ala Leu Ala Val Ala Ser Gly His Ser Ala Trp Ile Ser Lys 
                 325                330                335
Pro Pro Gly Val Ala Leu Pro Thr Val Ser Pro Pro Gly Val Asp Ala 
             340                345                350
Lys Ala Gln Val Lys Thr Glu Thr Ala Gly Pro Gln Gly Pro Pro His 
         355                360                365
Tyr Thr Asp Gln Pro Ser Thr Ser Gln Ile Ala Tyr Thr Ser Leu Ser 
     370                375                380
Leu Pro His Tyr Gly Ser Ala Phe Pro Ser Ile Ser Arg Pro Gln Phe 
 385                390                395                400
Asp Tyr Ser Asp His Gln Pro Ser Gly Pro Tyr Tyr Gly His Ser Gly 
                 405                410                415
Gln Ala Ser Gly Leu Tyr Ser Ala Phe Ser Tyr Met Gly Pro Ser Gln 
             420                425                430
Arg Pro Leu Tyr Thr Ala Ile Ser Asp Pro Ser Pro Ser Gly Pro Gln 
         435                440                445
Ser His Ser Pro Thr His Trp Glu Gln Pro Val Tyr Thr Thr Leu Ser 
     450                455                460
Arg Pro 
 465



<210> 1342
<211> 1214
<212> DNA
<213> Rattus norvegicus
<308> AJ001290
<400> 1342

aagtattaa  aagctggac  cttctgtca  tcggacatt  ttactcaca  gttcccaga  60
tgagggctg  gctggagac  gcagacatt  ccatagtgg  cctgtattt  gtcctggtc  120
tgtgcattg  tttctttgc  atgtggaaa  ctaatagaa  cactgtgag  ggatacttc  180
tggccgggc  ctctatgac  tgggtggcc  ttggtgcct  tctgtttgt  agcaatatt  240
ggagtgaac  cttcattgg  ctggtaggg  ctggagctg  aagtggatt  gcagtgggc  300
catgggagt  caatgcctt  ctgctcttg  aacttctgg  atgggtttt  atccctatt  360
acatccgct  aggggtgta  accatgcct  aatatttgt  caagaggtt  ggtggccat  420
ggattcagg  ctattttgc  gccttgtcc  tgctcctct  tatcttcac  aagctctcg  480
tggatctgt  ctcaggggc  ctctttatc  aggagtcct  gggttggaa  ctttatgtg  540
ctgtcatcc  gctcattgg  atgactgct  tgctgaccg  cactggagg  cttgttgca  600
tgatctaca  agacactct  caggctctg  tcatgatca  tggggcact  acacttatg  660
ttattagca  gatgaaggt  ggagggttt  aggaagtta  gagaaggta  atgttggcc  720
cacccaatg  tgcttccat  ttgttgaca  acaaccttt  caacacaaa  tcttgtatg  780
tgcatccta  gcaagatgc  ctaaagatg  tgagagatc  aacagatga  gacgtccca  840
ggcctggat  cattcttgg  cagacccca  cctcggtat  gtactggtg  gctgaccag  900
tcatcgtgc  gagggttct  gcagccaaa  acattgctc  tgccaaagg  tctactctg  960
tggctggct  cttgaagct  ctaccaatg  ttatcatag  cgtacccgg  atgatttcc  1020
ggatactgt  tgttgatga  atagcttgc  tcaacccag  acactgcat  caagtgtgt  1080
gaagcagag  tgggtgctc  aatattgct  acccacgcc  ggtgatgga  ttggttccc  1140
tgggccttc  gggcctgat  atggcagtg  tgattgcag  tctgatgag  gacttggcc  1200
ccatcttca  cagt  1214



<210> 1343
<211> 385
<212> PRT
<213> Rattus norvegicus
<308> CAA04650
<400> 1343

Met Arg Ala Ala Leu Glu Thr Ala Asp Ile Ala Ile Val Ala Leu Tyr 
  1               5                  10                  15
Phe Val Leu Val Val Cys Ile Gly Phe Phe Ala Met Trp Lys Ser Asn 
             20                  25                  30
Arg Ser Thr Val Ser Gly Tyr Phe Leu Ala Gly Arg Ser Met Thr Trp 
         35                  40                  45
Val Ala Ile Gly Ala Ser Leu Phe Val Ser Asn Ile Gly Ser Glu His 
     50                  55                  60
Phe Ile Gly Leu Val Gly Thr Gly Ala Ala Ser Gly Phe Ala Val Gly 
 65                  70                  75                  80
Ala Trp Glu Phe Asn Ala Leu Leu Leu Leu Gln Leu Leu Gly Trp Val 
                 85                  90                  95
Phe Ile Pro Ile Tyr Ile Arg Ser Gly Val Tyr Thr Met Pro Glu Tyr 
             100                105                110
Leu Ser Lys Arg Phe Gly Gly His Arg Ile Gln Val Tyr Phe Ala Ala 
         115                120                125
Leu Ser Leu Leu Leu Tyr Ile Phe Thr Lys Leu Ser Val Asp Leu Tyr 
     130                135                140
Ser Gly Ala Leu Phe Ile Gln Glu Ser Leu Gly Trp Asn Leu Tyr Val 
 145                150                155                160
Ser Val Ile Leu Leu Ile Gly Met Thr Ala Leu Leu Thr Val Thr Gly 
                 165                170                175
Gly Leu Val Ala Val Ile Tyr Thr Asp Thr Leu Gln Ala Leu Leu Met 
             180                185                190
Ile Ile Gly Ala Leu Thr Leu Met Val Ile Ser Met Met Lys Val Gly 
         195                200                205
Gly Phe Glu Glu Val Lys Arg Arg Tyr Met Leu Ala Ser Pro Asn Val 
     210                215                220
Ala Ser Ile Leu Leu Thr His Asn Leu Ser Asn Thr Asn Ser Cys Met 
 225                230                235                240
Val His Pro Lys Gln Asp Ala Leu Lys Met Leu Arg Asp Pro Thr Asp 
                 245                250                255
Glu Asp Val Pro Trp Pro Gly Phe Ile Leu Gly Gln Thr Pro Ala Ser 
             260                265                270
Val Trp Tyr Trp Cys Ala Asp Gln Val Ile Val Gln Arg Val Leu Ala 
         275                280                285
Ala Lys Asn Ile Ala His Ala Lys Gly Ser Thr Leu Met Ala Gly Phe 
     290                295                300
Leu Lys Leu Leu Pro Met Phe Ile Ile Val Val Pro Gly Met Ile Ser 
 305                310                315                320
Arg Ile Leu Phe Val Asp Asp Ile Ala Cys Ile Asn Pro Glu His Cys 
                 325                330                335
Met Gln Val Cys Gly Ser Arg Ala Gly Cys Ser Asn Ile Ala Tyr Pro 
             340                345                350
Arg Leu Val Met Glu Leu Val Pro Val Gly Leu Arg Gly Leu Met Met 
         355                360                365
Ala Val Met Ile Ala Ala Leu Met Ser Asp Leu Ala Ser Ile Phe Asn 
     370                375                380
Ser 
 385



<210> 1344
<211> 7516
<212> DNA
<213> Rattus norvegicus
<308> AJ001320
<400> 1344

gccgcgggc  ccagttccc  ggctacgcg  gagcgttcc  gccacaccg  gctcttggg  60
ccgtggtta  agcggagag  agccgagcg  tctacccac  ctgggagtc  cctccaggc  120
ggcgagcag  agtctcctt  tagttggtg  ttggcatca  tatagtttg  catcttgaa  180
aagatgttg  aaaccatag  caaaaaccg  gccctgcag  cagcagagc  cttgcaaag  240
aagctgaag  aacgcgggg  tgttgcaaa  gaagacaaa  tgagcctcc  gaagtctgt  300
ctgcagagt  cactcttca  tcagatcct  agccttcag  cttctctac  gcagctgaa  360
gaccaggta  acgttgcta  tttggcaac  gcaaatgct  accatgccc  cacaccgca  420
ttcagctct  ccatcatct  taatctgca  agtgagtca  ttttgctgt  tccaagtaa  480
gggaacctc  aagcaattt  tggacctgg  gctccacct  ccatggatg  aaagcctgc  540
tgtgaagaa  ttgatcagc  catcaaaag  atggcccag  gtcgccatg  ggaaatatt  600
gagctcctc  aacctccat  tggaggcct  ggcttcagt  tcgttgggc  cagaagtga  660
aacagggga  agctgggga  ttttgttca  gagattcaa  agggcagtg  ggctcacag  720
gatggcaga  ttaaggaga  tgaccagat  cttgccatt  atggccagg  cctagatca  780
acgatcaca  accagcagg  catcagcat  ctgcagaag  ccaaagaca  tatacagct  840
gttattgcc  gggggtctt  gccgcatat  tccagccca  gaatttccc  ttctccatc  900
gcagccagc  cagtttcag  ccactcgaa  ccaactcac  ggcagcatg  ggaaactat  960
gaacttgtg  atgatgggt  tggtctggg  tttggcatc  taggaggaa  agcaactgg  1020
gtgatagtc  agacaattt  gcctggagg  gtagctgac  agcatggtc  actatgcag  1080
ggagaccac  ttctgaaga  tggtgacac  gacctagca  ggatgagca  tgagcaagt  1140
gcacaagtc  tcaggcagt  tggaaacag  gttaaactg  tgattgcca  aggcgctgt  1200
gaagaaact  cagcacctt  ctctttggg  atcaccctc  cctcttcca  atctacttc  1260
gagatgcga  ttgatgctt  tactcagaa  aatgaagaa  gtgagacgt  cgatgtgga  1320
ctcactaaa  atgtccaag  attaggaat  accattgct  gctatattg  agataaaaa  1380
ttagagcct  caggaatct  tgtaaagag  attacaaag  gcagtgctg  ggagcttga  1440
ggaagaatc  agattggag  ccaaattgt  gcagtcgat  gcaccaacc  tcagggttt  1500
accaatcaa  aagcagtag  ggtgttacg  cacacggga  agacagtgc  tctgacact  1560
atgaggaag  gagccagcc  ggaagcaga  attacgtca  gagaagaca  cgcaaaaga  1620
gtggacctc  cagctgaaa  ttatgaaaa  gatgaagag  ctttgtcac  gaagagaag  1680
accagcata  tgccgattg  agaggaagg  tatccactg  tgtcaactg  gctggaaga  1740
actgaagat  tgcagcaag  agctgcctt  ctgacaaag  ggcagagga  tatgggaat  1800
aactatgaa  tagtggtgg  tcatgtgag  aagtttagt  agaacagtg  gctgggaat  1860
agtctggaa  caacagtgg  ccaccactt  atccggtct  tgctaccag  aggccctgt  1920
ggacacagc  ggaagctct  cagtggaga  gagctattg  aagtcaatg  tataaattt  1980
cttggggaa  accatcaag  tgtggtcaa  attttaaaa  aacttccta  cgatgtgac  2040
atggtatgt  gccgtcgga  tgtgccacc  accgccctg  cagaagtgg  tagcctgga  2100
atacatgat  ttgaactaa  agagaagcc  catatagac  taggagagt  cattggatc  2160
tcggagaca  aggatccca  gctggcgat  tccgatgtg  atcagaatg  cgaggagat  2220
cagaccccg  tggccatgt  ggaggcagg  attcaggcc  tagagctgg  gaaagggag  2280
aggggcctg  gcttcagca  cttagacta  caggacccc  tcgatccag  aaacacagt  2340
atagtcatt  gttctctgg  gcctggcgg  attgctgaa  aggatggac  gctttttcc  2400
ggagacagg  tcatgtttg  caatgacat  aacctggaa  acagcactc  ggaagaggc  2460
gtggaagcc  tgaagggag  gccctcagg  atggtgcgt  taggagtag  caagccttt  2520
cctctttca  cagaagaag  gtatgtttc  gccaaggaa  acacttttc  ctgctcacc  2580
cacacctgc  aggagatgg  cctgtctga  aaagccctc  tcagggctg  cttggctct  2640
atagataca  ctgatgctg  gtccgtagc  gaatcaaga  ttgagtctc  gttctctcc  2700
gataacgac  gtgtctact  tacacaagc  tctgtctta  ctcttcatg  tggtgcttg  2760
agtgatggc  tgaactacg  cccctctct  ccctcatct  ctcccaagg  cgtgaccaa  2820
agttctgac  tagtgctcg  tctgcattt  tccctggaa  aactctaca  acagaacct  2880
cttcagaga  agcatgctg  ctctcctcc  acagacatg  gcccagcag  cacctctgg  2940
ttcaccgtc  gtgactaca  acctgcaaa  gctgttgaa  aaaaatatg  gtgtgcaaa  3000
acagtagcg  ggactccct  gcagttgcc  agtggccta  gcaccacag  gctcgctcc  3060
gcactgcct  ctgtggctc  gaagtattt  acagagcag  gctctctgg  gtctgatgc  3120
gagtctgtc  ccctgcaga  catgtccca  gaagccttt  agaggacgg  tactatagc  3180
aaaggcagc  ccagtctag  catgacagt  agtgctaat  aagatggcc  gggagtgat  3240
gtgcgaagc  ttattcacg  aggcgccat  agtcgggat  gccgaattg  tgttggtga  3300
tgcattttg  ccattaatg  agaatccac  atcagttta  ccaatgccc  ggcacgggc  3360
atgctgaga  gacattctc  aattggacc  gacataaaa  ttacttacg  gcctgcaga  3420
catttggaa  agttcagag  aagttttgg  caacaagcc  gaggaataa  ggcactgga  3480
attttttct  catacactg  cagagatat  ccagaactc  cagagcgag  agaaggaga  3540
ggggaagaa  gtgaactgc  gaatgctgc  tatagcagc  ggagccagc  ccggagggt  3600
gaactttgg  gagagccca  caagtcctt  ggcatcagc  ttgttggtg  tcgggggat  3660
gggagccgg  tgagcaacg  cgaggtgat  aggggcatc  tcattaaac  tgttcttga  3720
gacagtcca  ctggcaaaa  tggaacttt  aagccggga  acagaatag  tgaggtgga  3780
gggatggac  tcagagatg  aagccatga  caagctgtg  aagccattc  gaaagcagg  3840
agccctgta  tgtttatgg  acagagcat  gtaaacaga  caaggaaat  ccctttgcc  3900
tccttgccg  acagccttt  ccctaagtg  agcttcagc  gcactaacc  atttgcaga  3960
tctctccag  tcacctctg  caaggcacc  agccagtca  aatccgagt  ggagaaggc  4020
acattgtgc  gtgtccctt  ctcctctcc  tcagtgttc  cagaaatga  cagtgatta  4080
gcacagcca  ctgcaacca  agtcgcaga  gatgaggac  aagaggatg  gtttgggta  4140
agctggaaa  atatccaag  gcgttatgg  acccttaca  gccagctcc  tatgattga  4200
ctggagaaa  gtcatagcg  tttgggtct  agtcttgct  ggaacaaag  ccgaaccag  4260
atgagtgtg  ttatagtgg  gattgatcc  actggagca  cagggagag  tggccgact  4320
cagattgcc  acgagcttt  agagatcaa  ggccaaata  tatatggca  aagtcatca  4380
aatgcttca  caatcatta  atgtgctcc  tctaaagta  aaatcattt  tatcagaaa  4440
gcagatgca  tgaatcaga  ggctgtatg  ccaggaagt  cagcagacc  tctaccttc  4500
acctcagaa  gtcctcaaa  taaggaggt  gaaccaagt  ttactacat  tgcttcagc  4560
gtggacctc  gctcactta  aaatgtgta  catctggag  ttcccaagg  tcaaggagg  4620
ttaggcatt  ctatctgtg  ggaagacac  ctcaatgga  tcacgatca  gagcctaac  4680
gagcgtggg  gagcagcca  ggatggaag  ctcaaacct  gggatcgca  cttggctgt  4740
gatgatgaa  ttgttgctg  ctgtcctat  gaaaagttc  tcagtcttc  gaagacggc  4800
aagacaact  taaaactga  tgttggagc  gagaacccg  gctgtcagg  tgtcccttc  4860
gcagctgtc  cagccagcg  agaaaggaa  gacagctcc  agacccctg  agtcccagc  4920
ccagacctg  aacccattc  aagtacgag  aggtcatcc  caccagcaa  ttttgcttc  4980
gaccctgcc  cctgcccca  catccctgg  tgtgaaaca  caattgaga  ttccaaagg  5040
caaacaggc  tgggactga  cattgtcgg  gggtcagac  cgttgctgg  tgctattat  5100
atccatgaa  tttatgaag  gggagcagc  tgtaaagat  gaagactgt  ggctggaga  5160
cagatttta  aggtaaatg  gattgacct  agaaaggct  cacatgatg  agcaatcaa  5220
gtcctgagg  agactccgc  aagagtacg  ctgacgctc  accgagatg  ggccccata  5280
aaagaggag  atgtatgtg  caccttcac  gtcgagctg  agaagaggc  gggcaaagg  5340
cttgggttg  gtattgttg  caaaagaaa  gacactgga  tgtttgtat  agacattgt  5400
aaaggaggc  ttgcagacg  cgatgggag  ctgatgcaa  gggaccaga  tttaatggt  5460
aatggagaa  atgtccgta  tgccaccca  gaagcagtt  ctgccctgc  caagtgttc  5520
ctaggcaca  taaccctcg  ggttggaag  atcaaagcc  ctccattcc  ctcagagag  5580
aggccttct  aaagcagtc  ggtgagtga  agcagcctg  catccttca  tctcccacg  5640
tctggaata  atacatcag  atcgtcaga  agtagtgcc  agaagaatg  gttagcatc  5700
gaaattcag  gattaagga  agtcgaaat  aaaaagggg  ctgctgacg  gctgggact  5760
agcattgcc  gaggagtgg  cagcccgct  ggcgacgtc  cgatattta  tgccatgat  5820
cacccaaat  gtgttgcag  tcaaaccca  aaactcaga  ttggggata  gattgtcac  5880
atctgtggc  catccactg  tgggatgac  cacacacag  cggttaact  gatgaaaaa  5940
gcctcaggc  ccattgaag  gcaggtggt  gctggagga  atgtgagtg  ggtcacggg  6000
catcagcaa  agcttgcca  tccttgcct  gctttcact  ggctgactt  cagcactat  6060
tttccggat  acttaggcc  tccacagtc  aagaccata  cactagacc  aggaccaga  6120
ggcttaggc  tcagcattg  aggtggcta  ggcagccct  atggagact  accaattta  6180
gttaaaaca  tgttcgcaa  gggagcagc  gcagaagat  ggcgtctaa  gaggggtga  6240
cagatcatt  ctgtcaacg  gcaaagtct  gaaggcgtg  cccatgaag  agctgttgc  6300
atccttaag  ggacaaagg  cactgtcac  ctcatggtt  tctcttgaa  tggctgtca  6360
agccgaagc  gccagctac  tgcccacct  ctactgtaa  ggagtggaa  tgttcacat  6420
acctgttga  tggggaaga  tacgcgggg  cgagaaaca  actgatttg  tcctaacaa  6480
caaacagca  ttttccttt  ccgtggcat  tcatagtct  atgctcaaa  agaagggag  6540
tttgcagag  taaacctca  ttttatctt  aagatatct  acaatttat  gtcatgtgg  6600
cagaattat  gtatgctca  tttgttagt  tggaaacaa  ataatgcaa  gttagccaa  6660
ggagatggc  tcagaaaaa  taagataaa  ggtggaaat  tagaaaaaa  aaggcagtc  6720
tgagtctta  agaacttcc  caatctaga  gtctacaaa  agaaaataa  gtgcccgca  6780
tactcttga  tagtccact  ttttaaaat  gtgaacatt  tgatgtact  gttctcctt  6840
cctcttatg  gtatttttt  tgctaaaat  gttcagcag  cttcataag  tttaaaaag  6900
aattgtgtt  aatgcatat  tcagtgttc  tttttagtt  tgacctgct  tattttcat  6960
ttgttgtat  taaaataat  ttgctaccc  gtgttggcc  cagttcttc  aagaaacat  7020
cactccacg  agtcatgga  gacagagaa  aagcccaga  ccttctaat  ctgatttaa  7080
ggactgata  aacgttgaa  acacgttca  taccatgct  ttgttttta  attagtatt  7140
atcttaatg  catagaaaa  gacaatgtg  tagtaatta  tttggttgt  tgccattag  7200
aaattgaca  aaaaattaa  ggggttaat  tgacttcat  tcactgctg  atattaaca  7260
cttacaata  aatagttta  gtctaaggg  aacagatgg  gctgtttac  gagcaactg  7320
tgaggaatt  tgtgttcaa  cccatttta  agcgtgaaa  tcctacatt  gaatagata  7380
agtcacttt  aatattatc  atatttgta  cagaagtcg  atacatata  tttattata  7440
cattcttgt  taaatgcag  attaaagtg  ataaataag  tttttgtgg  gtacagcaa  7500
aaaaaaaaa  aaaaaa  7516



<210> 1345
<211> 2054
<212> PRT
<213> Rattus norvegicus
<308> CAA04681
<400> 1345

Met Leu Glu Thr Ile Asp Lys Asn Arg Ala Leu Gln Ala Ala Glu Arg 
  1               5                  10                  15
Leu Gln Ser Lys Leu Lys Glu Arg Gly Asp Val Ala Asn Glu Asp Lys 
             20                  25                  30
Leu Ser Leu Leu Lys Ser Val Leu Gln Ser Pro Leu Phe Ser Gln Ile 
         35                  40                  45
Leu Ser Leu Gln Thr Ser Leu Gln Gln Leu Lys Asp Gln Val Asn Val 
     50                  55                  60
Ala Thr Leu Ala Thr Ala Asn Ala Asp His Ala His Thr Pro Gln Phe 
 65                  70                  75                  80
Ser Ser Ala Ile Ile Ser Asn Leu Gln Ser Glu Ser Leu Leu Leu Ser 
                 85                  90                  95
Pro Ser Asn Gly Asn Leu Glu Ala Ile Ser Gly Pro Gly Ala Pro Pro 
             100                105                110
Ala Met Asp Gly Lys Pro Ala Cys Glu Glu Leu Asp Gln Leu Ile Lys 
         115                120                125
Ser Met Ala Gln Gly Arg His Val Glu Ile Phe Glu Leu Leu Lys Pro 
     130                135                140
Pro Cys Gly Gly Leu Gly Phe Ser Val Val Gly Leu Arg Ser Glu Asn 
 145                150                155                160
Arg Gly Glu Leu Gly Ile Phe Val Gln Glu Ile Gln Glu Gly Ser Val 
                 165                170                175
Ala His Arg Asp Gly Arg Leu Lys Glu Thr Asp Gln Ile Leu Ala Ile 
             180                185                190
Asn Gly Gln Val Leu Asp Gln Thr Ile Thr His Gln Gln Ala Ile Ser 
         195                200                205
Ile Leu Gln Lys Ala Lys Asp Thr Ile Gln Leu Val Ile Ala Arg Gly 
     210                215                220
Ser Leu Pro His Ile Ser Ser Pro Arg Ile Ser Arg Ser Pro Ser Ala 
 225                230                235                240
Ala Ser Thr Val Ser Ala His Ser Asn Pro Thr His Trp Gln His Val 
                 245                250                255
Glu Thr Ile Glu Leu Val Asn Asp Gly Ser Gly Leu Gly Phe Gly Ile 
             260                265                270
Ile Gly Gly Lys Ala Thr Gly Val Ile Val Lys Thr Ile Leu Pro Gly 
         275                280                285
Gly Val Ala Asp Gln His Gly Arg Leu Cys Ser Gly Asp His Ile Leu 
     290                295                300
Lys Ile Gly Asp Thr Asp Leu Ala Gly Met Ser Ser Glu Gln Val Ala 
 305                310                315                320
Gln Val Leu Arg Gln Cys Gly Asn Arg Val Lys Leu Met Ile Ala Arg 
                 325                330                335
Gly Ala Val Glu Glu Thr Pro Ala Pro Ser Ser Leu Gly Ile Thr Leu 
             340                345                350
Ser Ser Ser Thr Ser Thr Ser Glu Met Arg Val Asp Ala Ser Thr Gln 
         355                360                365
Lys Asn Glu Glu Ser Glu Thr Phe Asp Val Glu Leu Thr Lys Asn Val 
     370                375                380
Gln Gly Leu Gly Ile Thr Ile Ala Gly Tyr Ile Gly Asp Lys Lys Leu 
 385                390                395                400
Glu Pro Ser Gly Ile Phe Val Lys Ser Ile Thr Lys Ser Ser Ala Val 
                 405                410                415
Glu Leu Asp Gly Arg Ile Gln Ile Gly Asp Gln Ile Val Ala Val Asp 
             420                425                430
Gly Thr Asn Leu Gln Gly Phe Thr Asn Gln Gln Ala Val Glu Val Leu 
         435                440                445
Arg His Thr Gly Gln Thr Val Arg Leu Thr Leu Met Arg Lys Gly Ala 
     450                455                460
Ser Gln Glu Ala Glu Ile Thr Ser Arg Glu Asp Thr Ala Lys Asp Val 
 465                470                475                480
Asp Leu Pro Ala Glu Asn Tyr Glu Lys Asp Glu Glu Ser Leu Ser Leu 
                 485                490                495
Lys Arg Ser Thr Ser Ile Leu Pro Ile Glu Glu Glu Gly Tyr Pro Leu 
             500                505                510
Leu Ser Thr Glu Leu Glu Glu Thr Glu Asp Val Gln Gln Glu Ala Ala 
         515                520                525
Leu Leu Thr Lys Trp Gln Arg Ile Met Gly Ile Asn Tyr Glu Ile Val 
     530                535                540
Val Ala His Val Ser Lys Phe Ser Glu Asn Ser Gly Leu Gly Ile Ser 
 545                550                555                560
Leu Glu Ala Thr Val Gly His His Phe Ile Arg Ser Val Leu Pro Glu 
                 565                570                575
Gly Pro Val Gly His Ser Gly Lys Leu Phe Ser Gly Asp Glu Leu Leu 
             580                585                590
Glu Val Asn Gly Ile Asn Leu Leu Gly Glu Asn His Gln Asp Val Val 
         595                600                605
Asn Ile Leu Lys Glu Leu Pro Ile Asp Val Thr Met Val Cys Cys Arg 
     610                615                620
Arg Thr Val Pro Pro Thr Ala Leu Ser Glu Val Asp Ser Leu Asp Ile 
 625                630                635                640
His Asp Leu Glu Leu Thr Glu Lys Pro His Ile Asp Leu Gly Glu Phe 
                 645                650                655
Ile Gly Ser Ser Glu Thr Glu Asp Pro Met Leu Ala Met Ser Asp Val 
             660                665                670
Asp Gln Asn Ala Glu Glu Ile Gln Thr Pro Leu Ala Met Trp Glu Ala 
         675                680                685
Gly Ile Gln Ala Ile Glu Leu Glu Lys Gly Ser Arg Gly Leu Gly Phe 
     690                695                700
Ser Ile Leu Asp Tyr Gln Asp Pro Ile Asp Pro Ala Asn Thr Val Ile 
 705                710                715                720
Val Ile Arg Ser Leu Val Pro Gly Gly Ile Ala Glu Lys Asp Gly Arg 
                 725                730                735
Leu Phe Pro Gly Asp Arg Leu Met Phe Val Asn Asp Ile Asn Leu Glu 
             740                745                750
Asn Ser Thr Leu Glu Glu Ala Val Glu Ala Leu Lys Gly Ala Pro Ser 
         755                760                765
Gly Met Val Arg Ile Gly Val Ala Lys Pro Leu Pro Leu Ser Pro Glu 
     770                775                780
Glu Gly Tyr Val Ser Ala Lys Glu Asp Thr Phe Leu Cys Ser Pro His 
 785                790                795                800
Thr Cys Lys Glu Met Gly Leu Ser Asp Lys Ala Leu Phe Arg Ala Asp 
                 805                810                815
Leu Ala Leu Ile Asp Thr Pro Asp Ala Glu Ser Val Ala Glu Ser Arg 
             820                825                830
Phe Glu Ser Gln Phe Ser Pro Asp Asn Asp Ser Val Tyr Ser Thr Gln 
         835                840                845
Ala Ser Val Leu Ser Leu His Asp Gly Ala Cys Ser Asp Gly Met Asn 
     850                855                860
Tyr Gly Pro Ser Leu Pro Ser Ser Pro Pro Lys Asp Val Thr Asn Ser 
 865                870                875                880
Ser Asp Leu Val Leu Gly Leu His Leu Ser Leu Glu Glu Leu Tyr Thr 
                 885                890                895
Gln Asn Leu Leu Gln Arg Gln His Ala Gly Ser Pro Pro Thr Asp Met 
             900                905                910
Ser Pro Ala Ala Thr Ser Gly Phe Thr Val Ser Asp Tyr Thr Pro Ala 
         915                920                925
Asn Ala Val Glu Gln Lys Tyr Glu Cys Ala Asn Thr Val Ala Trp Thr 
     930                935                940
Pro Ser Gln Leu Pro Ser Gly Leu Ser Thr Thr Glu Leu Ala Pro Ala 
 945                950                955                960
Leu Pro Ala Val Ala Pro Lys Tyr Leu Thr Glu Gln Ser Ser Leu Val 
                 965                970                975
Ser Asp Ala Glu Ser Val Thr Leu Gln Ser Met Ser Gln Glu Ala Phe 
             980                985                990
Glu Arg Thr Val Thr Ile Ala Lys Gly Ser Ser Ser Leu Gly Met Thr 
         995                1000                1005
Val Ser Ala Asn Lys Asp Gly Leu Gly Val Ile Val Arg Ser Ile Ile 
     1010                1015                1020
His Gly Gly Ala Ile Ser Arg Asp Gly Arg Ile Ala Val Gly Asp Cys 
 1025                1030                1035                1040
Ile Leu Ser Ile Asn Glu Glu Ser Thr Ile Ser Leu Thr Asn Ala Gln 
                 1045                1050                1055
Ala Arg Ala Met Leu Arg Arg His Ser Leu Ile Gly Pro Asp Ile Lys 
             1060                1065                1070
Ile Thr Tyr Val Pro Ala Glu His Leu Glu Glu Phe Arg Val Ser Phe 
         1075                1080                1085
Gly Gln Gln Ala Gly Gly Ile Met Ala Leu Asp Ile Phe Ser Ser Tyr 
     1090                1095                1100
Thr Gly Arg Asp Ile Pro Glu Leu Pro Glu Arg Glu Glu Gly Glu Gly 
 1105                1110                1115                1120
Glu Glu Ser Glu Leu Gln Asn Ala Ala Tyr Ser Ser Trp Ser Gln Pro 
                 1125                1130                1135
Arg Arg Val Glu Leu Trp Arg Glu Pro Ser Lys Ser Leu Gly Ile Ser 
             1140                1145                1150
Ile Val Gly Gly Arg Gly Met Gly Ser Arg Leu Ser Asn Gly Glu Val 
         1155                1160                1165
Met Arg Gly Ile Phe Ile Lys His Val Leu Glu Asp Ser Pro Ala Gly 
     1170                1175                1180
Lys Asn Gly Thr Leu Lys Pro Gly Asp Arg Ile Val Glu Val Asp Gly 
 1185                1190                1195                1200
Met Asp Leu Arg Asp Ala Ser His Glu Gln Ala Val Glu Ala Ile Arg 
                 1205                1210                1215
Lys Ala Gly Ser Pro Val Val Phe Met Val Gln Ser Ile Val Asn Arg 
             1220                1225                1230
Pro Arg Lys Ser Pro Leu Pro Ser Leu Pro His Ser Leu Tyr Pro Lys 
         1235                1240                1245
Cys Ser Phe Ser Ser Thr Asn Pro Phe Ala Glu Ser Leu Gln Leu Thr 
     1250                1255                1260
Ser Asp Lys Ala Pro Ser Gln Ser Glu Ser Glu Ser Glu Lys Ala Thr 
 1265                1270                1275                1280
Leu Cys Ser Val Pro Ser Ser Ser Pro Ser Val Phe Ser Glu Met Ser 
                 1285                1290                1295
Ser Asp Tyr Ala Gln Pro Ser Ala Thr Thr Val Ala Glu Asp Glu Asp 
             1300                1305                1310
Lys Glu Asp Glu Phe Gly Tyr Ser Trp Lys Asn Ile Gln Glu Arg Tyr 
         1315                1320                1325
Gly Thr Leu Thr Gly Gln Leu His Met Ile Glu Leu Glu Lys Gly His 
     1330                1335                1340
Ser Gly Leu Gly Leu Ser Leu Ala Gly Asn Lys Asp Arg Thr Arg Met 
 1345                1350                1355                1360
Ser Val Phe Ile Val Gly Ile Asp Pro Thr Gly Ala Ala Gly Arg Asp 
                 1365                1370                1375
Gly Arg Leu Gln Ile Ala Asp Glu Leu Leu Glu Ile Asn Gly Gln Ile 
             1380                1385                1390
Leu Tyr Gly Arg Ser His Gln Asn Ala Ser Ser Ile Ile Lys Cys Ala 
         1395                1400                1405
Pro Ser Lys Val Lys Ile Ile Phe Ile Arg Asn Ala Asp Ala Val Asn 
     1410                1415                1420
Gln Met Ala Val Cys Pro Gly Ser Ala Ala Asp Pro Leu Pro Ser Thr 
 1425                1430                1435                1440
Ser Glu Ser Pro Gln Asn Lys Glu Val Glu Pro Ser Ile Thr Thr Ser 
                 1445                1450                1455
Ala Ser Ala Val Asp Leu Ser Ser Leu Thr Asn Val Tyr His Leu Glu 
             1460                1465                1470
Leu Pro Lys Asp Gln Gly Gly Leu Gly Ile Ala Ile Cys Glu Glu Asp 
         1475                1480                1485
Thr Leu Asn Gly Val Thr Ile Lys Ser Leu Thr Glu Arg Gly Gly Ala 
     1490                1495                1500
Ala Lys Asp Gly Arg Leu Lys Pro Gly Asp Arg Ile Leu Ala Val Asp 
 1505                1510                1515                1520
Asp Glu Leu Val Ala Gly Cys Pro Ile Glu Lys Phe Ile Ser Leu Leu 
                 1525                1530                1535
Lys Thr Ala Lys Thr Thr Val Lys Leu Thr Val Gly Ala Glu Asn Pro 
             1540                1545                1550
Gly Cys Gln Ala Val Pro Ser Ala Ala Val Thr Ala Ser Gly Glu Arg 
         1555                1560                1565
Lys Asp Ser Ser Gln Thr Pro Ala Val Pro Ala Pro Asp Leu Glu Pro 
     1570                1575                1580
Ile Pro Ser Thr Ser Arg Ser Ser Thr Pro Ala Ile Phe Ala Ser Asp 
 1585                1590                1595                1600
Pro Ala Thr Cys Pro Ile Ile Pro Gly Cys Glu Thr Thr Ile Glu Ile 
                 1605                1610                1615
Ser Lys Gly Gln Thr Gly Leu Gly Leu Ser Ile Val Gly Gly Ser Asp 
             1620                1625                1630
Thr Leu Leu Gly Ala Ile Ile Ile His Glu Val Tyr Glu Glu Gly Ala 
         1635                1640                1645
Ala Cys Lys Asp Gly Arg Leu Trp Ala Gly Asp Gln Ile Leu Glu Val 
     1650                1655                1660
Asn Gly Ile Asp Leu Arg Lys Ala Thr His Asp Glu Ala Ile Asn Val 
 1665                1670                1675                1680
Leu Arg Gln Thr Pro Gln Arg Val Arg Leu Thr Leu Tyr Arg Asp Glu 
                 1685                1690                1695
Ala Pro Tyr Lys Glu Glu Asp Val Cys Asp Thr Phe Thr Val Glu Leu 
             1700                1705                1710
Gln Lys Arg Pro Gly Lys Gly Leu Gly Leu Ser Ile Val Gly Lys Arg 
         1715                1720                1725
Asn Asp Thr Gly Val Phe Val Ser Asp Ile Val Lys Gly Gly Ile Ala 
     1730                1735                1740
Asp Ala Asp Gly Arg Leu Met Gln Gly Asp Gln Ile Leu Met Val Asn 
 1745                1750                1755                1760
Gly Glu Asp Val Arg Asn Ala Thr Gln Glu Ala Val Ala Ala Leu Leu 
                 1765                1770                1775
Lys Cys Ser Leu Gly Thr Val Thr Leu Glu Val Gly Arg Ile Lys Ala 
             1780                1785                1790
Ala Pro Phe His Ser Glu Arg Arg Pro Ser Gln Ser Ser Gln Val Ser 
         1795                1800                1805
Glu Ser Ser Leu Ser Ser Phe Ser Leu Pro Arg Ser Gly Ile His Thr 
     1810                1815                1820
Ser Glu Ser Ser Glu Ser Ser Ala Lys Lys Asn Ala Leu Ala Ser Glu 
 1825                1830                1835                1840
Ile Gln Gly Leu Arg Thr Val Glu Ile Lys Lys Gly Pro Ala Asp Ala 
                 1845                1850                1855
Leu Gly Leu Ser Ile Ala Gly Gly Val Gly Ser Pro Leu Gly Asp Val 
             1860                1865                1870
Pro Ile Phe Ile Ala Met Met His Pro Asn Gly Val Ala Ala Gln Thr 
         1875                1880                1885
Gln Lys Leu Arg Val Gly Asp Arg Ile Val Thr Ile Cys Gly Thr Ser 
     1890                1895                1900
Thr Asp Gly Met Thr His Thr Gln Ala Val Asn Leu Met Lys Asn Ala 
 1905                1910                1915                1920
Ser Gly Ser Ile Glu Val Gln Val Val Ala Gly Gly Asp Val Ser Val 
                 1925                1930                1935
Val Thr Gly His Gln Gln Glu Leu Ala Asn Pro Cys Leu Ala Phe Thr 
             1940                1945                1950
Gly Leu Thr Ser Ser Thr Ile Phe Pro Asp Asp Leu Gly Pro Pro Gln 
         1955                1960                1965
Ser Lys Thr Ile Thr Leu Asp Arg Gly Pro Asp Gly Leu Gly Phe Ser 
     1970                1975                1980
Ile Val Gly Gly Tyr Gly Ser Pro His Gly Asp Leu Pro Ile Tyr Val 
 1985                1990                1995                2000
Lys Thr Val Phe Ala Lys Gly Ala Ala Ala Glu Asp Gly Arg Leu Lys 
                 2005                2010                2015
Arg Gly Asp Gln Ile Ile Ala Val Asn Gly Gln Ser Leu Glu Gly Val 
             2020                2025                2030
Thr His Glu Glu Ala Val Ala Ile Leu Lys Arg Thr Lys Gly Thr Val 
         2035                2040                2045
Thr Leu Met Val Leu Ser 
     2050



<210> 1346
<211> 3034
<212> DNA
<213> Homo sapiens
<308> AK058011
<400> 1346

ggcagctaa  ggctaatta  ttttaaaca  agaaagaat  tagcatatt  tttgagtgt  60
agtgggaat  tgtctaaaa  atagacttt  tttggaata  agtatcagt  gtctagttc  120
catgaaata  gacatgggt  acatggcta  tataggatg  ggggtcacc  ggtcatcat  180
aaaaccacc  ttaatgaac  ctaaactct  tgccttggg  agaccatac  aagaccgtc  240
aatccaata  cctgtttct  aagatggga  agcggagga  caaatggtg  aatgatttg  300
tgtcatgac  ttggcaaga  caagtgata  agttcagct  ttactatat  tttctattt  360
tggttatct  cgtatcttt  gaagttttg  gtttttttt  tatagtttt  tgaaagaaa  420
gatgggaat  agatttgtg  ttattttgc  taaacctat  tcgtgtgga  gatgtgtaa  480
gatttcaaa  aaaagacat  acagcaatg  tacttagat  ttgagttaa  aaatggtgt  540
tagtttgag  tacacatct  ttatgattt  cagtaatat  aatgatggt  atagcaaca  600
ttatgtaac  acaagttaa  attattcaa  gctccattc  gatttggaa  gaacagcag  660
ttttgcatc  aaggactga  tcttaagtc  tacttttgc  acttagtag  cgagtgacc  720
ataaaatga  aatggtaat  cacgcttct  ctcagtgta  ataaatgat  aagaataaa  780
atgcttatt  gagatcatt  taatctatg  agcactgta  gacataagc  gttatttat  840
aaaaaatat  attctaatg  tgccccagt  ttgctccaa  taacaaaac  tttaaagtc  900
taaaaacaa  taaaaattt  gggtaaaaa  gtaactttt  attaaataa  cattgcatt  960
cagttgagc  aaagataat  ttgaaattc  aaattgtgt  tagaaacga  actggagta  1020
ttgtgtcag  cattgtcaa  ggaggaatt  cagatgccg  tggaagact  atgcaggga  1080
accagatat  aatggtgaa  ggggaagac  ttcgtaatg  cacccaaga  gcggttgcc  1140
ctttgctaa  ggtgagtga  ggcagcctg  catctttca  ttttccact  tctggatcc  1200
gtacatctg  gtcactgga  agtagctca  agaagaatg  attggcatc  gaaatacag  1260
gattaagaa  agtcgaaat  aaaaaggtt  gggatagga  tgtcaccat  tgtggcaca  1320
ccactgagg  catgactca  acccaagca  ttaacctac  gaaaaatgc  tctggctcc  1380
ttgaaatgc  ggtggttgc  ggaggagac  tgagtgtgg  cacaggtca  cagcaggag  1440
ctgcaagtt  cagtctttc  ttcactggg  tgacgtcaa  cagtatatt  caggatgat  1500
taggacctc  tcaatgtaa  tctattaca  tagagcgag  accagatgg  ttaggcttc  1560
gtatagttg  aggatatgg  agccctcat  gagacttac  catttatgt  aaaacagtg  1620
ttgcaaagg  agcagcctc  gaagacgga  gtctgaaaa  gggcgatca  atcattgct  1680
tcaatgggc  gagtctaga  ggagtcacc  atgaagaag  tgttgccat  cttaaacgg  1740
caaaaggca  tgtcacttt  atggttctc  cttgaattg  ctgccagaa  tgaaccaac  1800
caaccccta  ctcacctcc  actgtaaag  gaatgcact  gtcctgaca  tttttatgc  1860
gtgttcagc  gggtcttca  aactgtagg  gggaaataa  acttaagtt  ctttttctc  1920
tctagaaat  ctttcctta  tgacaacct  acatcattt  tcttttctt  ttgcatttt  1980
tgaacttaa  gagaaggaa  atttgtgta  gtgaatctc  tttttattt  tggagatat  2040
taatgtttt  tagtcacat  ggcaagaat  attacatgc  aagctggtt  gtataaaga  2100
agataattc  aaagctaac  aaagaaaat  gcttcagta  gttaggatg  aaaatgaaa  2160
tataaaata  agaagaaaa  ctcggggag  ttaaaaaaa  tgcctcaat  tggcaatct  2220
cctcctccc  ccaccccaa  ctaaaaaaa  aaaaaaagg  tttctaatg  aaatcttta  2280
aaatactgt  agtatttta  aattttcaa  agtattata  aaacattgc  tctccccac  2340
tctaatatg  atatatatt  ttcctgcta  aattggttt  tacaattga  taaatggca  2400
atacatgaa  caatgtccc  aaattttat  aagaaatta  atttaatgc  catttcaat  2460
ttcattctt  tttttgacc  tttgtaaaa  attttcatg  tgctataag  aaatgatga  2520
gccacccca  gttgactat  gtttttcta  aaagcaact  tgctgctaa  catagagga  2580
catagaagg  ttccagaat  tttagtgct  gttttaaca  ccgatgcaa  attaaaaat  2640
tgttagtgt  ctgtgcaat  ggttttcaa  tcatattaa  cttaatgac  gagaacaat  2700
tgttactaa  tattttggt  gtatgccat  agtaaattg  tagaaaaat  aaggggatt  2760
acataactt  atttcattg  cttatatta  catcttata  tacaatagt  taagactaa  2820
ggaaacaga  ggagctgtt  attgagaca  ctggtgagg  attatcatg  gttcattcc  2880
attttagag  gtgaaactc  tacattaga  tatataaag  cactttaaa  atctatatt  2940
gtaacagaa  tagtgtaca  atattttat  acagcattt  tgtgtaaat  cagaattaa  3000
gtgaataaa  aagaatttt  agtggtgca  aaat  3034



<210> 1347
<211> 2042
<212> PRT
<213> Homo sapiens
<308> NP_003820
<400> 1347

Met Leu Glu Ala Ile Asp Lys Asn Arg Ala Leu His Ala Ala Glu Arg 
  1               5                  10                  15
Leu Gln Thr Lys Leu Arg Glu Arg Gly Asp Val Ala Asn Glu Asp Lys 
             20                  25                  30
Leu Ser Leu Leu Lys Ser Val Leu Gln Ser Pro Leu Phe Ser Gln Ile 
         35                  40                  45
Leu Ser Leu Gln Thr Ser Val Gln Gln Leu Lys Asp Gln Val Asn Ile 
     50                  55                  60
Ala Thr Ser Ala Thr Ser Asn Ile Glu Tyr Ala His Val Pro His Leu 
 65                  70                  75                  80
Ser Pro Ala Val Ile Pro Thr Leu Gln Asn Glu Ser Phe Leu Leu Ser 
                 85                  90                  95
Pro Asn Asn Gly Asn Leu Glu Ala Leu Thr Gly Pro Gly Ile Pro His 
             100                105                110
Ile Asn Gly Lys Pro Ala Cys Asp Glu Phe Asp Gln Leu Ile Lys Asn 
         115                120                125
Met Ala Gln Gly Arg His Val Glu Val Phe Glu Leu Leu Lys Pro Pro 
     130                135                140
Ser Gly Gly Leu Gly Phe Ser Val Val Gly Leu Arg Ser Glu Asn Arg 
 145                150                155                160
Gly Glu Leu Gly Ile Phe Val Gln Glu Ile Gln Glu Gly Ser Val Ala 
                 165                170                175
His Arg Asp Gly Arg Leu Lys Glu Thr Asp Gln Ile Leu Ala Ile Asn 
             180                185                190
Gly Gln Ala Leu Asp Gln Thr Ile Thr His Gln Gln Ala Ile Ser Ile 
         195                200                205
Leu Gln Lys Ala Lys Asp Thr Val Gln Leu Val Ile Ala Arg Gly Ser 
     210                215                220
Leu Pro Gln Leu Val Ser Pro Ile Val Ser Arg Ser Pro Ser Ala Ala 
 225                230                235                240
Ser Thr Ile Ser Ala His Ser Asn Pro Val His Trp Gln His Met Glu 
                 245                250                255
Thr Ile Glu Leu Val Asn Asp Gly Ser Gly Leu Gly Phe Gly Ile Ile 
             260                265                270
Gly Gly Lys Ala Thr Gly Val Ile Val Lys Thr Ile Leu Pro Gly Gly 
         275                280                285
Val Ala Asp Gln His Gly Arg Leu Cys Ser Gly Asp His Ile Leu Lys 
     290                295                300
Ile Gly Asp Thr Asp Leu Ala Gly Met Ser Ser Glu Gln Val Ala Gln 
 305                310                315                320
Val Leu Arg Gln Cys Gly Asn Arg Val Lys Leu Met Ile Ala Arg Gly 
                 325                330                335
Ala Ile Glu Glu Arg Thr Ala Pro Thr Ala Leu Gly Ile Thr Leu Ser 
             340                345                350
Ser Ser Pro Thr Ser Thr Pro Glu Leu Arg Val Asp Ala Ser Thr Gln 
         355                360                365
Lys Gly Glu Glu Ser Glu Thr Phe Asp Val Glu Leu Thr Lys Asn Val 
     370                375                380
Gln Gly Leu Gly Ile Thr Ile Ala Gly Tyr Ile Gly Asp Lys Lys Leu 
 385                390                395                400
Glu Pro Ser Gly Ile Phe Val Lys Ser Ile Thr Lys Ser Ser Ala Val 
                 405                410                415
Glu His Asp Gly Arg Ile Gln Ile Gly Asp Gln Ile Ile Ala Val Asp 
             420                425                430
Gly Thr Asn Leu Gln Gly Phe Thr Asn Gln Gln Ala Val Glu Val Leu 
         435                440                445
Arg His Thr Gly Gln Thr Val Leu Leu Thr Leu Met Arg Arg Gly Met 
     450                455                460
Lys Gln Glu Ala Glu Leu Met Ser Arg Glu Asp Val Thr Lys Asp Ala 
 465                470                475                480
Asp Leu Ser Pro Val Asn Ala Ser Ile Ile Lys Glu Asn Tyr Glu Lys 
                 485                490                495
Asp Glu Asp Phe Leu Ser Ser Thr Arg Asn Thr Asn Ile Leu Pro Thr 
             500                505                510
Glu Glu Glu Gly Tyr Pro Leu Leu Ser Ala Glu Ile Glu Glu Ile Glu 
         515                520                525
Asp Ala Gln Lys Gln Glu Ala Ala Leu Leu Thr Lys Trp Gln Arg Ile 
     530                535                540
Met Gly Ile Asn Tyr Glu Ile Val Val Ala His Val Ser Lys Phe Ser 
 545                550                555                560
Glu Asn Ser Gly Leu Gly Ile Ser Leu Glu Ala Thr Val Gly His His 
                 565                570                575
Phe Ile Arg Ser Val Leu Pro Glu Gly Pro Val Gly His Ser Gly Lys 
             580                585                590
Leu Phe Ser Gly Asp Glu Leu Leu Glu Val Asn Gly Ile Thr Leu Leu 
         595                600                605
Gly Glu Asn His Gln Asp Val Val Asn Ile Leu Lys Glu Leu Pro Ile 
     610                615                620
Glu Val Thr Met Val Cys Cys Arg Arg Thr Val Pro Pro Thr Thr Gln 
 625                630                635                640
Ser Glu Leu Asp Ser Leu Asp Leu Cys Asp Ile Glu Leu Thr Glu Lys 
                 645                650                655
Pro His Val Asp Leu Gly Glu Phe Ile Gly Ser Ser Glu Thr Glu Asp 
             660                665                670
Pro Val Leu Ala Met Thr Asp Ala Gly Gln Ser Thr Glu Glu Val Gln 
         675                680                685
Ala Pro Leu Ala Met Trp Glu Ala Gly Ile Gln His Ile Glu Leu Glu 
     690                695                700
Lys Gly Ser Lys Gly Leu Gly Phe Ser Ile Leu Asp Tyr Gln Asp Pro 
 705                710                715                720
Ile Asp Pro Ala Ser Thr Val Ile Ile Ile Arg Ser Leu Val Pro Gly 
                 725                730                735
Gly Ile Ala Glu Lys Asp Gly Arg Leu Leu Pro Gly Asp Arg Leu Met 
             740                745                750
Phe Val Asn Asp Val Asn Leu Glu Asn Ser Ser Leu Glu Glu Ala Val 
         755                760                765
Glu Ala Leu Lys Gly Ala Pro Ser Gly Thr Val Arg Ile Gly Val Ala 
     770                775                780
Lys Pro Leu Pro Leu Ser Pro Glu Glu Gly Tyr Val Ser Ala Lys Glu 
 785                790                795                800
Asp Ser Phe Leu Tyr Pro Pro His Ser Cys Glu Glu Ala Gly Leu Ala 
                 805                810                815
Asp Lys Pro Leu Phe Arg Ala Asp Leu Ala Leu Val Gly Thr Asn Asp 
             820                825                830
Ala Asp Leu Val Asp Glu Ser Thr Phe Glu Ser Pro Tyr Ser Pro Glu 
         835                840                845
Asn Asp Ser Ile Tyr Ser Thr Gln Ala Ser Ile Leu Ser Leu His Gly 
     850                855                860
Ser Ser Cys Gly Asp Gly Leu Asn Tyr Gly Ser Ser Leu Pro Ser Ser 
 865                870                875                880
Pro Pro Lys Asp Val Ile Glu Asn Ser Cys Asp Pro Val Leu Asp Leu 
                 885                890                895
His Met Ser Leu Glu Glu Leu Tyr Thr Gln Asn Leu Leu Gln Arg Gln 
             900                905                910
Asp Glu Asn Thr Pro Ser Val Asp Ile Ser Met Gly Pro Ala Ser Gly 
         915                920                925
Phe Thr Ile Asn Asp Tyr Thr Pro Ala Asn Ala Ile Glu Gln Gln Tyr 
     930                935                940
Glu Cys Glu Asn Thr Ile Val Trp Thr Glu Ser His Leu Pro Ser Glu 
 945                950                955                960
Val Ile Ser Ser Ala Glu Leu Pro Ser Val Leu Pro Asp Ser Ala Gly 
                 965                970                975
Lys Gly Ser Glu Tyr Leu Leu Glu Gln Ser Ser Leu Ala Cys Asn Ala 
             980                985                990
Glu Cys Val Met Leu Gln Asn Val Ser Lys Glu Ser Phe Glu Arg Thr 
         995                1000                1005
Ile Asn Ile Ala Lys Gly Asn Ser Ser Leu Gly Met Thr Val Ser Ala 
     1010                1015                1020
Asn Lys Asp Gly Leu Gly Met Ile Val Arg Ser Ile Ile His Gly Gly 
 1025                1030                1035                1040
Ala Ile Ser Arg Asp Gly Arg Ile Ala Ile Gly Asp Cys Ile Leu Ser 
                 1045                1050                1055
Ile Asn Glu Glu Ser Thr Ile Ser Val Thr Asn Ala Gln Ala Arg Ala 
             1060                1065                1070
Met Leu Arg Arg His Ser Leu Ile Gly Pro Asp Ile Lys Ile Thr Tyr 
         1075                1080                1085
Val Pro Ala Glu His Leu Glu Glu Phe Lys Ile Ser Leu Gly Gln Gln 
     1090                1095                1100
Ser Gly Arg Val Met Ala Leu Asp Ile Phe Ser Ser Tyr Thr Gly Arg 
 1105                1110                1115                1120
Asp Ile Pro Glu Leu Pro Glu Arg Glu Glu Gly Glu Gly Glu Glu Ser 
                 1125                1130                1135
Glu Leu Gln Asn Thr Ala Tyr Ser Asn Trp Asn Gln Pro Arg Arg Val 
             1140                1145                1150
Glu Leu Trp Arg Glu Pro Ser Lys Ser Leu Gly Ile Ser Ile Val Gly 
         1155                1160                1165
Gly Arg Gly Met Gly Ser Arg Leu Ser Asn Gly Glu Val Met Arg Gly 
     1170                1175                1180
Ile Phe Ile Lys His Val Leu Glu Asp Ser Pro Ala Gly Lys Asn Gly 
 1185                1190                1195                1200
Thr Leu Lys Pro Gly Asp Arg Ile Val Glu Val Asp Gly Met Asp Leu 
                 1205                1210                1215
Arg Asp Ala Ser His Glu Gln Ala Val Glu Ala Ile Arg Lys Ala Gly 
             1220                1225                1230
Asn Pro Val Val Phe Met Val Gln Ser Ile Ile Asn Arg Pro Arg Lys 
         1235                1240                1245
Ser Pro Leu Pro Ser Leu Leu His Asn Leu Tyr Pro Lys Tyr Asn Phe 
     1250                1255                1260
Ser Ser Thr Asn Pro Phe Ala Asp Ser Leu Gln Ile Asn Ala Asp Lys 
 1265                1270                1275                1280
Ala Pro Ser Gln Ser Glu Ser Glu Pro Glu Lys Ala Pro Leu Cys Ser 
                 1285                1290                1295
Val Pro Pro Pro Pro Pro Ser Ala Phe Ala Glu Met Gly Ser Asp His 
             1300                1305                1310
Thr Gln Ser Ser Ala Ser Lys Ile Ser Gln Asp Val Asp Lys Glu Asp 
         1315                1320                1325
Glu Phe Gly Tyr Ser Trp Lys Asn Ile Arg Glu Arg Tyr Gly Thr Leu 
     1330                1335                1340
Thr Gly Glu Leu His Met Ile Glu Leu Glu Lys Gly His Ser Gly Leu 
 1345                1350                1355                1360
Gly Leu Ser Leu Ala Gly Asn Lys Asp Arg Ser Arg Met Ser Val Phe 
                 1365                1370                1375
Ile Val Gly Ile Asp Pro Asn Gly Ala Ala Gly Lys Asp Gly Arg Leu 
             1380                1385                1390
Gln Ile Ala Asp Glu Leu Leu Glu Ile Asn Gly Gln Ile Leu Tyr Gly 
         1395                1400                1405
Arg Ser His Gln Asn Ala Ser Ser Ile Ile Lys Cys Ala Pro Ser Lys 
     1410                1415                1420
Val Lys Ile Ile Phe Ile Arg Asn Lys Asp Ala Val Asn Gln Met Ala 
 1425                1430                1435                1440
Val Cys Pro Gly Asn Ala Val Glu Pro Leu Pro Ser Asn Ser Glu Asn 
                 1445                1450                1455
Leu Gln Asn Lys Glu Thr Glu Pro Thr Val Thr Thr Ser Asp Ala Ala 
             1460                1465                1470
Val Asp Leu Ser Ser Phe Lys Asn Val Gln His Leu Glu Leu Pro Lys 
         1475                1480                1485
Asp Gln Gly Gly Leu Gly Ile Ala Ile Ser Glu Glu Asp Thr Leu Ser 
     1490                1495                1500
Gly Val Ile Ile Lys Ser Leu Thr Glu His Gly Val Ala Ala Thr Asp 
 1505                1510                1515                1520
Gly Arg Leu Lys Val Gly Asp Gln Ile Leu Ala Val Asp Asp Glu Ile 
                 1525                1530                1535
Val Val Gly Tyr Pro Ile Glu Lys Phe Ile Ser Leu Leu Lys Thr Ala 
             1540                1545                1550
Lys Met Thr Val Lys Leu Thr Ile His Ala Glu Asn Pro Asp Ser Gln 
         1555                1560                1565
Ala Val Pro Ser Ala Ala Gly Ala Ala Ser Gly Glu Lys Lys Asn Ser 
     1570                1575                1580
Ser Gln Ser Leu Met Val Pro Gln Ser Gly Ser Pro Glu Pro Glu Ser 
 1585                1590                1595                1600
Ile Arg Asn Thr Ser Arg Ser Ser Thr Pro Ala Ile Phe Ala Ser Asp 
                 1605                1610                1615
Pro Ala Thr Cys Pro Ile Ile Pro Gly Cys Glu Thr Thr Ile Glu Ile 
             1620                1625                1630
Ser Lys Gly Arg Thr Gly Leu Gly Leu Ser Ile Val Gly Gly Ser Asp 
         1635                1640                1645
Thr Leu Leu Gly Ala Ile Ile Ile His Glu Val Tyr Glu Glu Gly Ala 
     1650                1655                1660
Ala Cys Lys Asp Gly Arg Leu Trp Ala Gly Asp Gln Ile Leu Glu Val 
 1665                1670                1675                1680
Asn Gly Ile Asp Leu Arg Lys Ala Thr His Asp Glu Ala Ile Asn Val 
                 1685                1690                1695
Leu Arg Gln Thr Pro Gln Arg Val Arg Leu Thr Leu Tyr Arg Asp Glu 
             1700                1705                1710
Ala Pro Tyr Lys Glu Glu Glu Val Cys Asp Thr Leu Thr Ile Glu Leu 
         1715                1720                1725
Gln Lys Lys Pro Gly Lys Gly Leu Gly Leu Ser Ile Val Gly Lys Arg 
     1730                1735                1740
Asn Asp Thr Gly Val Phe Val Ser Asp Ile Val Lys Gly Gly Ile Ala 
 1745                1750                1755                1760
Asp Ala Asp Gly Arg Leu Met Gln Gly Asp Gln Ile Leu Met Val Asn 
                 1765                1770                1775
Gly Glu Asp Val Arg Asn Ala Thr Gln Glu Ala Val Ala Ala Leu Leu 
             1780                1785                1790
Lys Cys Ser Leu Gly Thr Val Thr Leu Glu Val Gly Arg Ile Lys Ala 
         1795                1800                1805
Gly Ser Ser Thr Ser Glu Ser Leu Glu Ser Ser Ser Lys Lys Asn Ala 
     1810                1815                1820
Leu Ala Ser Glu Ile Gln Gly Leu Arg Thr Val Glu Met Lys Lys Gly 
 1825                1830                1835                1840
Pro Thr Asp Ser Leu Gly Ile Ser Ile Ala Gly Gly Val Gly Ser Pro 
                 1845                1850                1855
Leu Gly Asp Val Pro Ile Phe Ile Ala Met Met His Pro Thr Gly Val 
             1860                1865                1870
Ala Ala Gln Thr Gln Lys Leu Arg Val Gly Asp Arg Ile Val Thr Ile 
         1875                1880                1885
Cys Gly Thr Ser Thr Glu Gly Met Thr His Thr Gln Ala Val Asn Leu 
     1890                1895                1900
Leu Lys Asn Ala Ser Gly Ser Ile Glu Met Gln Val Val Ala Gly Gly 
 1905                1910                1915                1920
Asp Val Ser Val Val Thr Gly His Gln Gln Glu Pro Ala Ser Ser Ser 
                 1925                1930                1935
Leu Ser Phe Thr Gly Leu Thr Ser Ser Ser Ile Phe Gln Asp Asp Leu 
             1940                1945                1950
Gly Pro Pro Gln Cys Lys Ser Ile Thr Leu Glu Arg Gly Pro Asp Gly 
         1955                1960                1965
Leu Gly Phe Ser Ile Val Gly Gly Tyr Gly Ser Pro His Gly Asp Leu 
     1970                1975                1980
Pro Ile Tyr Val Lys Thr Val Phe Ala Lys Gly Ala Ala Ser Glu Asp 
 1985                1990                1995                2000
Gly Arg Leu Lys Arg Gly Asp Gln Ile Ile Ala Val Asn Gly Gln Ser 
                 2005                2010                2015
Leu Glu Gly Val Thr His Glu Glu Ala Val Ala Ile Leu Lys Arg Thr 
             2020                2025                2030
Lys Gly Thr Val Thr Leu Met Val Leu Ser 
         2035                2040



<210> 1348
<211> 7516
<212> DNA
<213> Rattus norvegicus
<308> AJ001320
<400> 1348

gccgcgggc  ccagttccc  ggctacgcg  gagcgttcc  gccacaccg  gctcttggg  60
ccgtggtta  agcggagag  agccgagcg  tctacccac  ctgggagtc  cctccaggc  120
ggcgagcag  agtctcctt  tagttggtg  ttggcatca  tatagtttg  catcttgaa  180
aagatgttg  aaaccatag  caaaaaccg  gccctgcag  cagcagagc  cttgcaaag  240
aagctgaag  aacgcgggg  tgttgcaaa  gaagacaaa  tgagcctcc  gaagtctgt  300
ctgcagagt  cactcttca  tcagatcct  agccttcag  cttctctac  gcagctgaa  360
gaccaggta  acgttgcta  tttggcaac  gcaaatgct  accatgccc  cacaccgca  420
ttcagctct  ccatcatct  taatctgca  agtgagtca  ttttgctgt  tccaagtaa  480
gggaacctc  aagcaattt  tggacctgg  gctccacct  ccatggatg  aaagcctgc  540
tgtgaagaa  ttgatcagc  catcaaaag  atggcccag  gtcgccatg  ggaaatatt  600
gagctcctc  aacctccat  tggaggcct  ggcttcagt  tcgttgggc  cagaagtga  660
aacagggga  agctgggga  ttttgttca  gagattcaa  agggcagtg  ggctcacag  720
gatggcaga  ttaaggaga  tgaccagat  cttgccatt  atggccagg  cctagatca  780
acgatcaca  accagcagg  catcagcat  ctgcagaag  ccaaagaca  tatacagct  840
gttattgcc  gggggtctt  gccgcatat  tccagccca  gaatttccc  ttctccatc  900
gcagccagc  cagtttcag  ccactcgaa  ccaactcac  ggcagcatg  ggaaactat  960
gaacttgtg  atgatgggt  tggtctggg  tttggcatc  taggaggaa  agcaactgg  1020
gtgatagtc  agacaattt  gcctggagg  gtagctgac  agcatggtc  actatgcag  1080
ggagaccac  ttctgaaga  tggtgacac  gacctagca  ggatgagca  tgagcaagt  1140
gcacaagtc  tcaggcagt  tggaaacag  gttaaactg  tgattgcca  aggcgctgt  1200
gaagaaact  cagcacctt  ctctttggg  atcaccctc  cctcttcca  atctacttc  1260
gagatgcga  ttgatgctt  tactcagaa  aatgaagaa  gtgagacgt  cgatgtgga  1320
ctcactaaa  atgtccaag  attaggaat  accattgct  gctatattg  agataaaaa  1380
ttagagcct  caggaatct  tgtaaagag  attacaaag  gcagtgctg  ggagcttga  1440
ggaagaatc  agattggag  ccaaattgt  gcagtcgat  gcaccaacc  tcagggttt  1500
accaatcaa  aagcagtag  ggtgttacg  cacacggga  agacagtgc  tctgacact  1560
atgaggaag  gagccagcc  ggaagcaga  attacgtca  gagaagaca  cgcaaaaga  1620
gtggacctc  cagctgaaa  ttatgaaaa  gatgaagag  ctttgtcac  gaagagaag  1680
accagcata  tgccgattg  agaggaagg  tatccactg  tgtcaactg  gctggaaga  1740
actgaagat  tgcagcaag  agctgcctt  ctgacaaag  ggcagagga  tatgggaat  1800
aactatgaa  tagtggtgg  tcatgtgag  aagtttagt  agaacagtg  gctgggaat  1860
agtctggaa  caacagtgg  ccaccactt  atccggtct  tgctaccag  aggccctgt  1920
ggacacagc  ggaagctct  cagtggaga  gagctattg  aagtcaatg  tataaattt  1980
cttggggaa  accatcaag  tgtggtcaa  attttaaaa  aacttccta  cgatgtgac  2040
atggtatgt  gccgtcgga  tgtgccacc  accgccctg  cagaagtgg  tagcctgga  2100
atacatgat  ttgaactaa  agagaagcc  catatagac  taggagagt  cattggatc  2160
tcggagaca  aggatccca  gctggcgat  tccgatgtg  atcagaatg  cgaggagat  2220
cagaccccg  tggccatgt  ggaggcagg  attcaggcc  tagagctgg  gaaagggag  2280
aggggcctg  gcttcagca  cttagacta  caggacccc  tcgatccag  aaacacagt  2340
atagtcatt  gttctctgg  gcctggcgg  attgctgaa  aggatggac  gctttttcc  2400
ggagacagg  tcatgtttg  caatgacat  aacctggaa  acagcactc  ggaagaggc  2460
gtggaagcc  tgaagggag  gccctcagg  atggtgcgt  taggagtag  caagccttt  2520
cctctttca  cagaagaag  gtatgtttc  gccaaggaa  acacttttc  ctgctcacc  2580
cacacctgc  aggagatgg  cctgtctga  aaagccctc  tcagggctg  cttggctct  2640
atagataca  ctgatgctg  gtccgtagc  gaatcaaga  ttgagtctc  gttctctcc  2700
gataacgac  gtgtctact  tacacaagc  tctgtctta  ctcttcatg  tggtgcttg  2760
agtgatggc  tgaactacg  cccctctct  ccctcatct  ctcccaagg  cgtgaccaa  2820
agttctgac  tagtgctcg  tctgcattt  tccctggaa  aactctaca  acagaacct  2880
cttcagaga  agcatgctg  ctctcctcc  acagacatg  gcccagcag  cacctctgg  2940
ttcaccgtc  gtgactaca  acctgcaaa  gctgttgaa  aaaaatatg  gtgtgcaaa  3000
acagtagcg  ggactccct  gcagttgcc  agtggccta  gcaccacag  gctcgctcc  3060
gcactgcct  ctgtggctc  gaagtattt  acagagcag  gctctctgg  gtctgatgc  3120
gagtctgtc  ccctgcaga  catgtccca  gaagccttt  agaggacgg  tactatagc  3180
aaaggcagc  ccagtctag  catgacagt  agtgctaat  aagatggcc  gggagtgat  3240
gtgcgaagc  ttattcacg  aggcgccat  agtcgggat  gccgaattg  tgttggtga  3300
tgcattttg  ccattaatg  agaatccac  atcagttta  ccaatgccc  ggcacgggc  3360
atgctgaga  gacattctc  aattggacc  gacataaaa  ttacttacg  gcctgcaga  3420
catttggaa  agttcagag  aagttttgg  caacaagcc  gaggaataa  ggcactgga  3480
attttttct  catacactg  cagagatat  ccagaactc  cagagcgag  agaaggaga  3540
ggggaagaa  gtgaactgc  gaatgctgc  tatagcagc  ggagccagc  ccggagggt  3600
gaactttgg  gagagccca  caagtcctt  ggcatcagc  ttgttggtg  tcgggggat  3660
gggagccgg  tgagcaacg  cgaggtgat  aggggcatc  tcattaaac  tgttcttga  3720
gacagtcca  ctggcaaaa  tggaacttt  aagccggga  acagaatag  tgaggtgga  3780
gggatggac  tcagagatg  aagccatga  caagctgtg  aagccattc  gaaagcagg  3840
agccctgta  tgtttatgg  acagagcat  gtaaacaga  caaggaaat  ccctttgcc  3900
tccttgccg  acagccttt  ccctaagtg  agcttcagc  gcactaacc  atttgcaga  3960
tctctccag  tcacctctg  caaggcacc  agccagtca  aatccgagt  ggagaaggc  4020
acattgtgc  gtgtccctt  ctcctctcc  tcagtgttc  cagaaatga  cagtgatta  4080
gcacagcca  ctgcaacca  agtcgcaga  gatgaggac  aagaggatg  gtttgggta  4140
agctggaaa  atatccaag  gcgttatgg  acccttaca  gccagctcc  tatgattga  4200
ctggagaaa  gtcatagcg  tttgggtct  agtcttgct  ggaacaaag  ccgaaccag  4260
atgagtgtg  ttatagtgg  gattgatcc  actggagca  cagggagag  tggccgact  4320
cagattgcc  acgagcttt  agagatcaa  ggccaaata  tatatggca  aagtcatca  4380
aatgcttca  caatcatta  atgtgctcc  tctaaagta  aaatcattt  tatcagaaa  4440
gcagatgca  tgaatcaga  ggctgtatg  ccaggaagt  cagcagacc  tctaccttc  4500
acctcagaa  gtcctcaaa  taaggaggt  gaaccaagt  ttactacat  tgcttcagc  4560
gtggacctc  gctcactta  aaatgtgta  catctggag  ttcccaagg  tcaaggagg  4620
ttaggcatt  ctatctgtg  ggaagacac  ctcaatgga  tcacgatca  gagcctaac  4680
gagcgtggg  gagcagcca  ggatggaag  ctcaaacct  gggatcgca  cttggctgt  4740
gatgatgaa  ttgttgctg  ctgtcctat  gaaaagttc  tcagtcttc  gaagacggc  4800
aagacaact  taaaactga  tgttggagc  gagaacccg  gctgtcagg  tgtcccttc  4860
gcagctgtc  cagccagcg  agaaaggaa  gacagctcc  agacccctg  agtcccagc  4920
ccagacctg  aacccattc  aagtacgag  aggtcatcc  caccagcaa  ttttgcttc  4980
gaccctgcc  cctgcccca  catccctgg  tgtgaaaca  caattgaga  ttccaaagg  5040
caaacaggc  tgggactga  cattgtcgg  gggtcagac  cgttgctgg  tgctattat  5100
atccatgaa  tttatgaag  gggagcagc  tgtaaagat  gaagactgt  ggctggaga  5160
cagatttta  aggtaaatg  gattgacct  agaaaggct  cacatgatg  agcaatcaa  5220
gtcctgagg  agactccgc  aagagtacg  ctgacgctc  accgagatg  ggccccata  5280
aaagaggag  atgtatgtg  caccttcac  gtcgagctg  agaagaggc  gggcaaagg  5340
cttgggttg  gtattgttg  caaaagaaa  gacactgga  tgtttgtat  agacattgt  5400
aaaggaggc  ttgcagacg  cgatgggag  ctgatgcaa  gggaccaga  tttaatggt  5460
aatggagaa  atgtccgta  tgccaccca  gaagcagtt  ctgccctgc  caagtgttc  5520
ctaggcaca  taaccctcg  ggttggaag  atcaaagcc  ctccattcc  ctcagagag  5580
aggccttct  aaagcagtc  ggtgagtga  agcagcctg  catccttca  tctcccacg  5640
tctggaata  atacatcag  atcgtcaga  agtagtgcc  agaagaatg  gttagcatc  5700
gaaattcag  gattaagga  agtcgaaat  aaaaagggg  ctgctgacg  gctgggact  5760
agcattgcc  gaggagtgg  cagcccgct  ggcgacgtc  cgatattta  tgccatgat  5820
cacccaaat  gtgttgcag  tcaaaccca  aaactcaga  ttggggata  gattgtcac  5880
atctgtggc  catccactg  tgggatgac  cacacacag  cggttaact  gatgaaaaa  5940
gcctcaggc  ccattgaag  gcaggtggt  gctggagga  atgtgagtg  ggtcacggg  6000
catcagcaa  agcttgcca  tccttgcct  gctttcact  ggctgactt  cagcactat  6060
tttccggat  acttaggcc  tccacagtc  aagaccata  cactagacc  aggaccaga  6120
ggcttaggc  tcagcattg  aggtggcta  ggcagccct  atggagact  accaattta  6180
gttaaaaca  tgttcgcaa  gggagcagc  gcagaagat  ggcgtctaa  gaggggtga  6240
cagatcatt  ctgtcaacg  gcaaagtct  gaaggcgtg  cccatgaag  agctgttgc  6300
atccttaag  ggacaaagg  cactgtcac  ctcatggtt  tctcttgaa  tggctgtca  6360
agccgaagc  gccagctac  tgcccacct  ctactgtaa  ggagtggaa  tgttcacat  6420
acctgttga  tggggaaga  tacgcgggg  cgagaaaca  actgatttg  tcctaacaa  6480
caaacagca  ttttccttt  ccgtggcat  tcatagtct  atgctcaaa  agaagggag  6540
tttgcagag  taaacctca  ttttatctt  aagatatct  acaatttat  gtcatgtgg  6600
cagaattat  gtatgctca  tttgttagt  tggaaacaa  ataatgcaa  gttagccaa  6660
ggagatggc  tcagaaaaa  taagataaa  ggtggaaat  tagaaaaaa  aaggcagtc  6720
tgagtctta  agaacttcc  caatctaga  gtctacaaa  agaaaataa  gtgcccgca  6780
tactcttga  tagtccact  ttttaaaat  gtgaacatt  tgatgtact  gttctcctt  6840
cctcttatg  gtatttttt  tgctaaaat  gttcagcag  cttcataag  tttaaaaag  6900
aattgtgtt  aatgcatat  tcagtgttc  tttttagtt  tgacctgct  tattttcat  6960
ttgttgtat  taaaataat  ttgctaccc  gtgttggcc  cagttcttc  aagaaacat  7020
cactccacg  agtcatgga  gacagagaa  aagcccaga  ccttctaat  ctgatttaa  7080
ggactgata  aacgttgaa  acacgttca  taccatgct  ttgttttta  attagtatt  7140
atcttaatg  catagaaaa  gacaatgtg  tagtaatta  tttggttgt  tgccattag  7200
aaattgaca  aaaaattaa  ggggttaat  tgacttcat  tcactgctg  atattaaca  7260
cttacaata  aatagttta  gtctaaggg  aacagatgg  gctgtttac  gagcaactg  7320
tgaggaatt  tgtgttcaa  cccatttta  agcgtgaaa  tcctacatt  gaatagata  7380
agtcacttt  aatattatc  atatttgta  cagaagtcg  atacatata  tttattata  7440
cattcttgt  taaatgcag  attaaagtg  ataaataag  tttttgtgg  gtacagcaa  7500
aaaaaaaaa  aaaaaa  7516



<210> 1349
<211> 2054
<212> PRT
<213> Rattus norvegicus
<308> CAA04681
<400> 1349

Met Leu Glu Thr Ile Asp Lys Asn Arg Ala Leu Gln Ala Ala Glu Arg 
  1               5                  10                  15
Leu Gln Ser Lys Leu Lys Glu Arg Gly Asp Val Ala Asn Glu Asp Lys 
             20                  25                  30
Leu Ser Leu Leu Lys Ser Val Leu Gln Ser Pro Leu Phe Ser Gln Ile 
         35                  40                  45
Leu Ser Leu Gln Thr Ser Leu Gln Gln Leu Lys Asp Gln Val Asn Val 
     50                  55                  60
Ala Thr Leu Ala Thr Ala Asn Ala Asp His Ala His Thr Pro Gln Phe 
 65                  70                  75                  80
Ser Ser Ala Ile Ile Ser Asn Leu Gln Ser Glu Ser Leu Leu Leu Ser 
                 85                  90                  95
Pro Ser Asn Gly Asn Leu Glu Ala Ile Ser Gly Pro Gly Ala Pro Pro 
             100                105                110
Ala Met Asp Gly Lys Pro Ala Cys Glu Glu Leu Asp Gln Leu Ile Lys 
         115                120                125
Ser Met Ala Gln Gly Arg His Val Glu Ile Phe Glu Leu Leu Lys Pro 
     130                135                140
Pro Cys Gly Gly Leu Gly Phe Ser Val Val Gly Leu Arg Ser Glu Asn 
 145                150                155                160
Arg Gly Glu Leu Gly Ile Phe Val Gln Glu Ile Gln Glu Gly Ser Val 
                 165                170                175
Ala His Arg Asp Gly Arg Leu Lys Glu Thr Asp Gln Ile Leu Ala Ile 
             180                185                190
Asn Gly Gln Val Leu Asp Gln Thr Ile Thr His Gln Gln Ala Ile Ser 
         195                200                205
Ile Leu Gln Lys Ala Lys Asp Thr Ile Gln Leu Val Ile Ala Arg Gly 
     210                215                220
Ser Leu Pro His Ile Ser Ser Pro Arg Ile Ser Arg Ser Pro Ser Ala 
 225                230                235                240
Ala Ser Thr Val Ser Ala His Ser Asn Pro Thr His Trp Gln His Val 
                 245                250                255
Glu Thr Ile Glu Leu Val Asn Asp Gly Ser Gly Leu Gly Phe Gly Ile 
             260                265                270
Ile Gly Gly Lys Ala Thr Gly Val Ile Val Lys Thr Ile Leu Pro Gly 
         275                280                285
Gly Val Ala Asp Gln His Gly Arg Leu Cys Ser Gly Asp His Ile Leu 
     290                295                300
Lys Ile Gly Asp Thr Asp Leu Ala Gly Met Ser Ser Glu Gln Val Ala 
 305                310                315                320
Gln Val Leu Arg Gln Cys Gly Asn Arg Val Lys Leu Met Ile Ala Arg 
                 325                330                335
Gly Ala Val Glu Glu Thr Pro Ala Pro Ser Ser Leu Gly Ile Thr Leu 
             340                345                350
Ser Ser Ser Thr Ser Thr Ser Glu Met Arg Val Asp Ala Ser Thr Gln 
         355                360                365
Lys Asn Glu Glu Ser Glu Thr Phe Asp Val Glu Leu Thr Lys Asn Val 
     370                375                380
Gln Gly Leu Gly Ile Thr Ile Ala Gly Tyr Ile Gly Asp Lys Lys Leu 
 385                390                395                400
Glu Pro Ser Gly Ile Phe Val Lys Ser Ile Thr Lys Ser Ser Ala Val 
                 405                410                415
Glu Leu Asp Gly Arg Ile Gln Ile Gly Asp Gln Ile Val Ala Val Asp 
             420                425                430
Gly Thr Asn Leu Gln Gly Phe Thr Asn Gln Gln Ala Val Glu Val Leu 
         435                440                445
Arg His Thr Gly Gln Thr Val Arg Leu Thr Leu Met Arg Lys Gly Ala 
     450                455                460
Ser Gln Glu Ala Glu Ile Thr Ser Arg Glu Asp Thr Ala Lys Asp Val 
 465                470                475                480
Asp Leu Pro Ala Glu Asn Tyr Glu Lys Asp Glu Glu Ser Leu Ser Leu 
                 485                490                495
Lys Arg Ser Thr Ser Ile Leu Pro Ile Glu Glu Glu Gly Tyr Pro Leu 
             500                505                510
Leu Ser Thr Glu Leu Glu Glu Thr Glu Asp Val Gln Gln Glu Ala Ala 
         515                520                525
Leu Leu Thr Lys Trp Gln Arg Ile Met Gly Ile Asn Tyr Glu Ile Val 
     530                535                540
Val Ala His Val Ser Lys Phe Ser Glu Asn Ser Gly Leu Gly Ile Ser 
 545                550                555                560
Leu Glu Ala Thr Val Gly His His Phe Ile Arg Ser Val Leu Pro Glu 
                 565                570                575
Gly Pro Val Gly His Ser Gly Lys Leu Phe Ser Gly Asp Glu Leu Leu 
             580                585                590
Glu Val Asn Gly Ile Asn Leu Leu Gly Glu Asn His Gln Asp Val Val 
         595                600                605
Asn Ile Leu Lys Glu Leu Pro Ile Asp Val Thr Met Val Cys Cys Arg 
     610                615                620
Arg Thr Val Pro Pro Thr Ala Leu Ser Glu Val Asp Ser Leu Asp Ile 
 625                630                635                640
His Asp Leu Glu Leu Thr Glu Lys Pro His Ile Asp Leu Gly Glu Phe 
                 645                650                655
Ile Gly Ser Ser Glu Thr Glu Asp Pro Met Leu Ala Met Ser Asp Val 
             660                665                670
Asp Gln Asn Ala Glu Glu Ile Gln Thr Pro Leu Ala Met Trp Glu Ala 
         675                680                685
Gly Ile Gln Ala Ile Glu Leu Glu Lys Gly Ser Arg Gly Leu Gly Phe 
     690                695                700
Ser Ile Leu Asp Tyr Gln Asp Pro Ile Asp Pro Ala Asn Thr Val Ile 
 705                710                715                720
Val Ile Arg Ser Leu Val Pro Gly Gly Ile Ala Glu Lys Asp Gly Arg 
                 725                730                735
Leu Phe Pro Gly Asp Arg Leu Met Phe Val Asn Asp Ile Asn Leu Glu 
             740                745                750
Asn Ser Thr Leu Glu Glu Ala Val Glu Ala Leu Lys Gly Ala Pro Ser 
         755                760                765
Gly Met Val Arg Ile Gly Val Ala Lys Pro Leu Pro Leu Ser Pro Glu 
     770                775                780
Glu Gly Tyr Val Ser Ala Lys Glu Asp Thr Phe Leu Cys Ser Pro His 
 785                790                795                800
Thr Cys Lys Glu Met Gly Leu Ser Asp Lys Ala Leu Phe Arg Ala Asp 
                 805                810                815
Leu Ala Leu Ile Asp Thr Pro Asp Ala Glu Ser Val Ala Glu Ser Arg 
             820                825                830
Phe Glu Ser Gln Phe Ser Pro Asp Asn Asp Ser Val Tyr Ser Thr Gln 
         835                840                845
Ala Ser Val Leu Ser Leu His Asp Gly Ala Cys Ser Asp Gly Met Asn 
     850                855                860
Tyr Gly Pro Ser Leu Pro Ser Ser Pro Pro Lys Asp Val Thr Asn Ser 
 865                870                875                880
Ser Asp Leu Val Leu Gly Leu His Leu Ser Leu Glu Glu Leu Tyr Thr 
                 885                890                895
Gln Asn Leu Leu Gln Arg Gln His Ala Gly Ser Pro Pro Thr Asp Met 
             900                905                910
Ser Pro Ala Ala Thr Ser Gly Phe Thr Val Ser Asp Tyr Thr Pro Ala 
         915                920                925
Asn Ala Val Glu Gln Lys Tyr Glu Cys Ala Asn Thr Val Ala Trp Thr 
     930                935                940
Pro Ser Gln Leu Pro Ser Gly Leu Ser Thr Thr Glu Leu Ala Pro Ala 
 945                950                955                960
Leu Pro Ala Val Ala Pro Lys Tyr Leu Thr Glu Gln Ser Ser Leu Val 
                 965                970                975
Ser Asp Ala Glu Ser Val Thr Leu Gln Ser Met Ser Gln Glu Ala Phe 
             980                985                990
Glu Arg Thr Val Thr Ile Ala Lys Gly Ser Ser Ser Leu Gly Met Thr 
         995                1000                1005
Val Ser Ala Asn Lys Asp Gly Leu Gly Val Ile Val Arg Ser Ile Ile 
     1010                1015                1020
His Gly Gly Ala Ile Ser Arg Asp Gly Arg Ile Ala Val Gly Asp Cys 
 1025                1030                1035                1040
Ile Leu Ser Ile Asn Glu Glu Ser Thr Ile Ser Leu Thr Asn Ala Gln 
                 1045                1050                1055
Ala Arg Ala Met Leu Arg Arg His Ser Leu Ile Gly Pro Asp Ile Lys 
             1060                1065                1070
Ile Thr Tyr Val Pro Ala Glu His Leu Glu Glu Phe Arg Val Ser Phe 
         1075                1080                1085
Gly Gln Gln Ala Gly Gly Ile Met Ala Leu Asp Ile Phe Ser Ser Tyr 
     1090                1095                1100
Thr Gly Arg Asp Ile Pro Glu Leu Pro Glu Arg Glu Glu Gly Glu Gly 
 1105                1110                1115                1120
Glu Glu Ser Glu Leu Gln Asn Ala Ala Tyr Ser Ser Trp Ser Gln Pro 
                 1125                1130                1135
Arg Arg Val Glu Leu Trp Arg Glu Pro Ser Lys Ser Leu Gly Ile Ser 
             1140                1145                1150
Ile Val Gly Gly Arg Gly Met Gly Ser Arg Leu Ser Asn Gly Glu Val 
         1155                1160                1165
Met Arg Gly Ile Phe Ile Lys His Val Leu Glu Asp Ser Pro Ala Gly 
     1170                1175                1180
Lys Asn Gly Thr Leu Lys Pro Gly Asp Arg Ile Val Glu Val Asp Gly 
 1185                1190                1195                1200
Met Asp Leu Arg Asp Ala Ser His Glu Gln Ala Val Glu Ala Ile Arg 
                 1205                1210                1215
Lys Ala Gly Ser Pro Val Val Phe Met Val Gln Ser Ile Val Asn Arg 
             1220                1225                1230
Pro Arg Lys Ser Pro Leu Pro Ser Leu Pro His Ser Leu Tyr Pro Lys 
         1235                1240                1245
Cys Ser Phe Ser Ser Thr Asn Pro Phe Ala Glu Ser Leu Gln Leu Thr 
     1250                1255                1260
Ser Asp Lys Ala Pro Ser Gln Ser Glu Ser Glu Ser Glu Lys Ala Thr 
 1265                1270                1275                1280
Leu Cys Ser Val Pro Ser Ser Ser Pro Ser Val Phe Ser Glu Met Ser 
                 1285                1290                1295
Ser Asp Tyr Ala Gln Pro Ser Ala Thr Thr Val Ala Glu Asp Glu Asp 
             1300                1305                1310
Lys Glu Asp Glu Phe Gly Tyr Ser Trp Lys Asn Ile Gln Glu Arg Tyr 
         1315                1320                1325
Gly Thr Leu Thr Gly Gln Leu His Met Ile Glu Leu Glu Lys Gly His 
     1330                1335                1340
Ser Gly Leu Gly Leu Ser Leu Ala Gly Asn Lys Asp Arg Thr Arg Met 
 1345                1350                1355                1360
Ser Val Phe Ile Val Gly Ile Asp Pro Thr Gly Ala Ala Gly Arg Asp 
                 1365                1370                1375
Gly Arg Leu Gln Ile Ala Asp Glu Leu Leu Glu Ile Asn Gly Gln Ile 
             1380                1385                1390
Leu Tyr Gly Arg Ser His Gln Asn Ala Ser Ser Ile Ile Lys Cys Ala 
         1395                1400                1405
Pro Ser Lys Val Lys Ile Ile Phe Ile Arg Asn Ala Asp Ala Val Asn 
     1410                1415                1420
Gln Met Ala Val Cys Pro Gly Ser Ala Ala Asp Pro Leu Pro Ser Thr 
 1425                1430                1435                1440
Ser Glu Ser Pro Gln Asn Lys Glu Val Glu Pro Ser Ile Thr Thr Ser 
                 1445                1450                1455
Ala Ser Ala Val Asp Leu Ser Ser Leu Thr Asn Val Tyr His Leu Glu 
             1460                1465                1470
Leu Pro Lys Asp Gln Gly Gly Leu Gly Ile Ala Ile Cys Glu Glu Asp 
         1475                1480                1485
Thr Leu Asn Gly Val Thr Ile Lys Ser Leu Thr Glu Arg Gly Gly Ala 
     1490                1495                1500
Ala Lys Asp Gly Arg Leu Lys Pro Gly Asp Arg Ile Leu Ala Val Asp 
 1505                1510                1515                1520
Asp Glu Leu Val Ala Gly Cys Pro Ile Glu Lys Phe Ile Ser Leu Leu 
                 1525                1530                1535
Lys Thr Ala Lys Thr Thr Val Lys Leu Thr Val Gly Ala Glu Asn Pro 
             1540                1545                1550
Gly Cys Gln Ala Val Pro Ser Ala Ala Val Thr Ala Ser Gly Glu Arg 
         1555                1560                1565
Lys Asp Ser Ser Gln Thr Pro Ala Val Pro Ala Pro Asp Leu Glu Pro 
     1570                1575                1580
Ile Pro Ser Thr Ser Arg Ser Ser Thr Pro Ala Ile Phe Ala Ser Asp 
 1585                1590                1595                1600
Pro Ala Thr Cys Pro Ile Ile Pro Gly Cys Glu Thr Thr Ile Glu Ile 
                 1605                1610                1615
Ser Lys Gly Gln Thr Gly Leu Gly Leu Ser Ile Val Gly Gly Ser Asp 
             1620                1625                1630
Thr Leu Leu Gly Ala Ile Ile Ile His Glu Val Tyr Glu Glu Gly Ala 
         1635                1640                1645
Ala Cys Lys Asp Gly Arg Leu Trp Ala Gly Asp Gln Ile Leu Glu Val 
     1650                1655                1660
Asn Gly Ile Asp Leu Arg Lys Ala Thr His Asp Glu Ala Ile Asn Val 
 1665                1670                1675                1680
Leu Arg Gln Thr Pro Gln Arg Val Arg Leu Thr Leu Tyr Arg Asp Glu 
                 1685                1690                1695
Ala Pro Tyr Lys Glu Glu Asp Val Cys Asp Thr Phe Thr Val Glu Leu 
             1700                1705                1710
Gln Lys Arg Pro Gly Lys Gly Leu Gly Leu Ser Ile Val Gly Lys Arg 
         1715                1720                1725
Asn Asp Thr Gly Val Phe Val Ser Asp Ile Val Lys Gly Gly Ile Ala 
     1730                1735                1740
Asp Ala Asp Gly Arg Leu Met Gln Gly Asp Gln Ile Leu Met Val Asn 
 1745                1750                1755                1760
Gly Glu Asp Val Arg Asn Ala Thr Gln Glu Ala Val Ala Ala Leu Leu 
                 1765                1770                1775
Lys Cys Ser Leu Gly Thr Val Thr Leu Glu Val Gly Arg Ile Lys Ala 
             1780                1785                1790
Ala Pro Phe His Ser Glu Arg Arg Pro Ser Gln Ser Ser Gln Val Ser 
         1795                1800                1805
Glu Ser Ser Leu Ser Ser Phe Ser Leu Pro Arg Ser Gly Ile His Thr 
     1810                1815                1820
Ser Glu Ser Ser Glu Ser Ser Ala Lys Lys Asn Ala Leu Ala Ser Glu 
 1825                1830                1835                1840
Ile Gln Gly Leu Arg Thr Val Glu Ile Lys Lys Gly Pro Ala Asp Ala 
                 1845                1850                1855
Leu Gly Leu Ser Ile Ala Gly Gly Val Gly Ser Pro Leu Gly Asp Val 
             1860                1865                1870
Pro Ile Phe Ile Ala Met Met His Pro Asn Gly Val Ala Ala Gln Thr 
         1875                1880                1885
Gln Lys Leu Arg Val Gly Asp Arg Ile Val Thr Ile Cys Gly Thr Ser 
     1890                1895                1900
Thr Asp Gly Met Thr His Thr Gln Ala Val Asn Leu Met Lys Asn Ala 
 1905                1910                1915                1920
Ser Gly Ser Ile Glu Val Gln Val Val Ala Gly Gly Asp Val Ser Val 
                 1925                1930                1935
Val Thr Gly His Gln Gln Glu Leu Ala Asn Pro Cys Leu Ala Phe Thr 
             1940                1945                1950
Gly Leu Thr Ser Ser Thr Ile Phe Pro Asp Asp Leu Gly Pro Pro Gln 
         1955                1960                1965
Ser Lys Thr Ile Thr Leu Asp Arg Gly Pro Asp Gly Leu Gly Phe Ser 
     1970                1975                1980
Ile Val Gly Gly Tyr Gly Ser Pro His Gly Asp Leu Pro Ile Tyr Val 
 1985                1990                1995                2000
Lys Thr Val Phe Ala Lys Gly Ala Ala Ala Glu Asp Gly Arg Leu Lys 
                 2005                2010                2015
Arg Gly Asp Gln Ile Ile Ala Val Asn Gly Gln Ser Leu Glu Gly Val 
             2020                2025                2030
Thr His Glu Glu Ala Val Ala Ile Leu Lys Arg Thr Lys Gly Thr Val 
         2035                2040                2045
Thr Leu Met Val Leu Ser 
     2050



<210> 1350
<211> 3034
<212> DNA
<213> Homo sapiens
<308> AK058011
<400> 1350

ggcagctaa  ggctaatta  ttttaaaca  agaaagaat  tagcatatt  tttgagtgt  60
agtgggaat  tgtctaaaa  atagacttt  tttggaata  agtatcagt  gtctagttc  120
catgaaata  gacatgggt  acatggcta  tataggatg  ggggtcacc  ggtcatcat  180
aaaaccacc  ttaatgaac  ctaaactct  tgccttggg  agaccatac  aagaccgtc  240
aatccaata  cctgtttct  aagatggga  agcggagga  caaatggtg  aatgatttg  300
tgtcatgac  ttggcaaga  caagtgata  agttcagct  ttactatat  tttctattt  360
tggttatct  cgtatcttt  gaagttttg  gtttttttt  tatagtttt  tgaaagaaa  420
gatgggaat  agatttgtg  ttattttgc  taaacctat  tcgtgtgga  gatgtgtaa  480
gatttcaaa  aaaagacat  acagcaatg  tacttagat  ttgagttaa  aaatggtgt  540
tagtttgag  tacacatct  ttatgattt  cagtaatat  aatgatggt  atagcaaca  600
ttatgtaac  acaagttaa  attattcaa  gctccattc  gatttggaa  gaacagcag  660
ttttgcatc  aaggactga  tcttaagtc  tacttttgc  acttagtag  cgagtgacc  720
ataaaatga  aatggtaat  cacgcttct  ctcagtgta  ataaatgat  aagaataaa  780
atgcttatt  gagatcatt  taatctatg  agcactgta  gacataagc  gttatttat  840
aaaaaatat  attctaatg  tgccccagt  ttgctccaa  taacaaaac  tttaaagtc  900
taaaaacaa  taaaaattt  gggtaaaaa  gtaactttt  attaaataa  cattgcatt  960
cagttgagc  aaagataat  ttgaaattc  aaattgtgt  tagaaacga  actggagta  1020
ttgtgtcag  cattgtcaa  ggaggaatt  cagatgccg  tggaagact  atgcaggga  1080
accagatat  aatggtgaa  ggggaagac  ttcgtaatg  cacccaaga  gcggttgcc  1140
ctttgctaa  ggtgagtga  ggcagcctg  catctttca  ttttccact  tctggatcc  1200
gtacatctg  gtcactgga  agtagctca  agaagaatg  attggcatc  gaaatacag  1260
gattaagaa  agtcgaaat  aaaaaggtt  gggatagga  tgtcaccat  tgtggcaca  1320
ccactgagg  catgactca  acccaagca  ttaacctac  gaaaaatgc  tctggctcc  1380
ttgaaatgc  ggtggttgc  ggaggagac  tgagtgtgg  cacaggtca  cagcaggag  1440
ctgcaagtt  cagtctttc  ttcactggg  tgacgtcaa  cagtatatt  caggatgat  1500
taggacctc  tcaatgtaa  tctattaca  tagagcgag  accagatgg  ttaggcttc  1560
gtatagttg  aggatatgg  agccctcat  gagacttac  catttatgt  aaaacagtg  1620
ttgcaaagg  agcagcctc  gaagacgga  gtctgaaaa  gggcgatca  atcattgct  1680
tcaatgggc  gagtctaga  ggagtcacc  atgaagaag  tgttgccat  cttaaacgg  1740
caaaaggca  tgtcacttt  atggttctc  cttgaattg  ctgccagaa  tgaaccaac  1800
caaccccta  ctcacctcc  actgtaaag  gaatgcact  gtcctgaca  tttttatgc  1860
gtgttcagc  gggtcttca  aactgtagg  gggaaataa  acttaagtt  ctttttctc  1920
tctagaaat  ctttcctta  tgacaacct  acatcattt  tcttttctt  ttgcatttt  1980
tgaacttaa  gagaaggaa  atttgtgta  gtgaatctc  tttttattt  tggagatat  2040
taatgtttt  tagtcacat  ggcaagaat  attacatgc  aagctggtt  gtataaaga  2100
agataattc  aaagctaac  aaagaaaat  gcttcagta  gttaggatg  aaaatgaaa  2160
tataaaata  agaagaaaa  ctcggggag  ttaaaaaaa  tgcctcaat  tggcaatct  2220
cctcctccc  ccaccccaa  ctaaaaaaa  aaaaaaagg  tttctaatg  aaatcttta  2280
aaatactgt  agtatttta  aattttcaa  agtattata  aaacattgc  tctccccac  2340
tctaatatg  atatatatt  ttcctgcta  aattggttt  tacaattga  taaatggca  2400
atacatgaa  caatgtccc  aaattttat  aagaaatta  atttaatgc  catttcaat  2460
ttcattctt  tttttgacc  tttgtaaaa  attttcatg  tgctataag  aaatgatga  2520
gccacccca  gttgactat  gtttttcta  aaagcaact  tgctgctaa  catagagga  2580
catagaagg  ttccagaat  tttagtgct  gttttaaca  ccgatgcaa  attaaaaat  2640
tgttagtgt  ctgtgcaat  ggttttcaa  tcatattaa  cttaatgac  gagaacaat  2700
tgttactaa  tattttggt  gtatgccat  agtaaattg  tagaaaaat  aaggggatt  2760
acataactt  atttcattg  cttatatta  catcttata  tacaatagt  taagactaa  2820
ggaaacaga  ggagctgtt  attgagaca  ctggtgagg  attatcatg  gttcattcc  2880
attttagag  gtgaaactc  tacattaga  tatataaag  cactttaaa  atctatatt  2940
gtaacagaa  tagtgtaca  atattttat  acagcattt  tgtgtaaat  cagaattaa  3000
gtgaataaa  aagaatttt  agtggtgca  aaat  3034



<210> 1351
<211> 2042
<212> PRT
<213> Homo sapiens
<308> NP_003820
<400> 1351

Met Leu Glu Ala Ile Asp Lys Asn Arg Ala Leu His Ala Ala Glu Arg 
  1               5                  10                  15
Leu Gln Thr Lys Leu Arg Glu Arg Gly Asp Val Ala Asn Glu Asp Lys 
             20                  25                  30
Leu Ser Leu Leu Lys Ser Val Leu Gln Ser Pro Leu Phe Ser Gln Ile 
         35                  40                  45
Leu Ser Leu Gln Thr Ser Val Gln Gln Leu Lys Asp Gln Val Asn Ile 
     50                  55                  60
Ala Thr Ser Ala Thr Ser Asn Ile Glu Tyr Ala His Val Pro His Leu 
 65                  70                  75                  80
Ser Pro Ala Val Ile Pro Thr Leu Gln Asn Glu Ser Phe Leu Leu Ser 
                 85                  90                  95
Pro Asn Asn Gly Asn Leu Glu Ala Leu Thr Gly Pro Gly Ile Pro His 
             100                105                110
Ile Asn Gly Lys Pro Ala Cys Asp Glu Phe Asp Gln Leu Ile Lys Asn 
         115                120                125
Met Ala Gln Gly Arg His Val Glu Val Phe Glu Leu Leu Lys Pro Pro 
     130                135                140
Ser Gly Gly Leu Gly Phe Ser Val Val Gly Leu Arg Ser Glu Asn Arg 
 145                150                155                160
Gly Glu Leu Gly Ile Phe Val Gln Glu Ile Gln Glu Gly Ser Val Ala 
                 165                170                175
His Arg Asp Gly Arg Leu Lys Glu Thr Asp Gln Ile Leu Ala Ile Asn 
             180                185                190
Gly Gln Ala Leu Asp Gln Thr Ile Thr His Gln Gln Ala Ile Ser Ile 
         195                200                205
Leu Gln Lys Ala Lys Asp Thr Val Gln Leu Val Ile Ala Arg Gly Ser 
     210                215                220
Leu Pro Gln Leu Val Ser Pro Ile Val Ser Arg Ser Pro Ser Ala Ala 
 225                230                235                240
Ser Thr Ile Ser Ala His Ser Asn Pro Val His Trp Gln His Met Glu 
                 245                250                255
Thr Ile Glu Leu Val Asn Asp Gly Ser Gly Leu Gly Phe Gly Ile Ile 
             260                265                270
Gly Gly Lys Ala Thr Gly Val Ile Val Lys Thr Ile Leu Pro Gly Gly 
         275                280                285
Val Ala Asp Gln His Gly Arg Leu Cys Ser Gly Asp His Ile Leu Lys 
     290                295                300
Ile Gly Asp Thr Asp Leu Ala Gly Met Ser Ser Glu Gln Val Ala Gln 
 305                310                315                320
Val Leu Arg Gln Cys Gly Asn Arg Val Lys Leu Met Ile Ala Arg Gly 
                 325                330                335
Ala Ile Glu Glu Arg Thr Ala Pro Thr Ala Leu Gly Ile Thr Leu Ser 
             340                345                350
Ser Ser Pro Thr Ser Thr Pro Glu Leu Arg Val Asp Ala Ser Thr Gln 
         355                360                365
Lys Gly Glu Glu Ser Glu Thr Phe Asp Val Glu Leu Thr Lys Asn Val 
     370                375                380
Gln Gly Leu Gly Ile Thr Ile Ala Gly Tyr Ile Gly Asp Lys Lys Leu 
 385                390                395                400
Glu Pro Ser Gly Ile Phe Val Lys Ser Ile Thr Lys Ser Ser Ala Val 
                 405                410                415
Glu His Asp Gly Arg Ile Gln Ile Gly Asp Gln Ile Ile Ala Val Asp 
             420                425                430
Gly Thr Asn Leu Gln Gly Phe Thr Asn Gln Gln Ala Val Glu Val Leu 
         435                440                445
Arg His Thr Gly Gln Thr Val Leu Leu Thr Leu Met Arg Arg Gly Met 
     450                455                460
Lys Gln Glu Ala Glu Leu Met Ser Arg Glu Asp Val Thr Lys Asp Ala 
 465                470                475                480
Asp Leu Ser Pro Val Asn Ala Ser Ile Ile Lys Glu Asn Tyr Glu Lys 
                 485                490                495
Asp Glu Asp Phe Leu Ser Ser Thr Arg Asn Thr Asn Ile Leu Pro Thr 
             500                505                510
Glu Glu Glu Gly Tyr Pro Leu Leu Ser Ala Glu Ile Glu Glu Ile Glu 
         515                520                525
Asp Ala Gln Lys Gln Glu Ala Ala Leu Leu Thr Lys Trp Gln Arg Ile 
     530                535                540
Met Gly Ile Asn Tyr Glu Ile Val Val Ala His Val Ser Lys Phe Ser 
 545                550                555                560
Glu Asn Ser Gly Leu Gly Ile Ser Leu Glu Ala Thr Val Gly His His 
                 565                570                575
Phe Ile Arg Ser Val Leu Pro Glu Gly Pro Val Gly His Ser Gly Lys 
             580                585                590
Leu Phe Ser Gly Asp Glu Leu Leu Glu Val Asn Gly Ile Thr Leu Leu 
         595                600                605
Gly Glu Asn His Gln Asp Val Val Asn Ile Leu Lys Glu Leu Pro Ile 
     610                615                620
Glu Val Thr Met Val Cys Cys Arg Arg Thr Val Pro Pro Thr Thr Gln 
 625                630                635                640
Ser Glu Leu Asp Ser Leu Asp Leu Cys Asp Ile Glu Leu Thr Glu Lys 
                 645                650                655
Pro His Val Asp Leu Gly Glu Phe Ile Gly Ser Ser Glu Thr Glu Asp 
             660                665                670
Pro Val Leu Ala Met Thr Asp Ala Gly Gln Ser Thr Glu Glu Val Gln 
         675                680                685
Ala Pro Leu Ala Met Trp Glu Ala Gly Ile Gln His Ile Glu Leu Glu 
     690                695                700
Lys Gly Ser Lys Gly Leu Gly Phe Ser Ile Leu Asp Tyr Gln Asp Pro 
 705                710                715                720
Ile Asp Pro Ala Ser Thr Val Ile Ile Ile Arg Ser Leu Val Pro Gly 
                 725                730                735
Gly Ile Ala Glu Lys Asp Gly Arg Leu Leu Pro Gly Asp Arg Leu Met 
             740                745                750
Phe Val Asn Asp Val Asn Leu Glu Asn Ser Ser Leu Glu Glu Ala Val 
         755                760                765
Glu Ala Leu Lys Gly Ala Pro Ser Gly Thr Val Arg Ile Gly Val Ala 
     770                775                780
Lys Pro Leu Pro Leu Ser Pro Glu Glu Gly Tyr Val Ser Ala Lys Glu 
 785                790                795                800
Asp Ser Phe Leu Tyr Pro Pro His Ser Cys Glu Glu Ala Gly Leu Ala 
                 805                810                815
Asp Lys Pro Leu Phe Arg Ala Asp Leu Ala Leu Val Gly Thr Asn Asp 
             820                825                830
Ala Asp Leu Val Asp Glu Ser Thr Phe Glu Ser Pro Tyr Ser Pro Glu 
         835                840                845
Asn Asp Ser Ile Tyr Ser Thr Gln Ala Ser Ile Leu Ser Leu His Gly 
     850                855                860
Ser Ser Cys Gly Asp Gly Leu Asn Tyr Gly Ser Ser Leu Pro Ser Ser 
 865                870                875                880
Pro Pro Lys Asp Val Ile Glu Asn Ser Cys Asp Pro Val Leu Asp Leu 
                 885                890                895
His Met Ser Leu Glu Glu Leu Tyr Thr Gln Asn Leu Leu Gln Arg Gln 
             900                905                910
Asp Glu Asn Thr Pro Ser Val Asp Ile Ser Met Gly Pro Ala Ser Gly 
         915                920                925
Phe Thr Ile Asn Asp Tyr Thr Pro Ala Asn Ala Ile Glu Gln Gln Tyr 
     930                935                940
Glu Cys Glu Asn Thr Ile Val Trp Thr Glu Ser His Leu Pro Ser Glu 
 945                950                955                960
Val Ile Ser Ser Ala Glu Leu Pro Ser Val Leu Pro Asp Ser Ala Gly 
                 965                970                975
Lys Gly Ser Glu Tyr Leu Leu Glu Gln Ser Ser Leu Ala Cys Asn Ala 
             980                985                990
Glu Cys Val Met Leu Gln Asn Val Ser Lys Glu Ser Phe Glu Arg Thr 
         995                1000                1005
Ile Asn Ile Ala Lys Gly Asn Ser Ser Leu Gly Met Thr Val Ser Ala 
     1010                1015                1020
Asn Lys Asp Gly Leu Gly Met Ile Val Arg Ser Ile Ile His Gly Gly 
 1025                1030                1035                1040
Ala Ile Ser Arg Asp Gly Arg Ile Ala Ile Gly Asp Cys Ile Leu Ser 
                 1045                1050                1055
Ile Asn Glu Glu Ser Thr Ile Ser Val Thr Asn Ala Gln Ala Arg Ala 
             1060                1065                1070
Met Leu Arg Arg His Ser Leu Ile Gly Pro Asp Ile Lys Ile Thr Tyr 
         1075                1080                1085
Val Pro Ala Glu His Leu Glu Glu Phe Lys Ile Ser Leu Gly Gln Gln 
     1090                1095                1100
Ser Gly Arg Val Met Ala Leu Asp Ile Phe Ser Ser Tyr Thr Gly Arg 
 1105                1110                1115                1120
Asp Ile Pro Glu Leu Pro Glu Arg Glu Glu Gly Glu Gly Glu Glu Ser 
                 1125                1130                1135
Glu Leu Gln Asn Thr Ala Tyr Ser Asn Trp Asn Gln Pro Arg Arg Val 
             1140                1145                1150
Glu Leu Trp Arg Glu Pro Ser Lys Ser Leu Gly Ile Ser Ile Val Gly 
         1155                1160                1165
Gly Arg Gly Met Gly Ser Arg Leu Ser Asn Gly Glu Val Met Arg Gly 
     1170                1175                1180
Ile Phe Ile Lys His Val Leu Glu Asp Ser Pro Ala Gly Lys Asn Gly 
 1185                1190                1195                1200
Thr Leu Lys Pro Gly Asp Arg Ile Val Glu Val Asp Gly Met Asp Leu 
                 1205                1210                1215
Arg Asp Ala Ser His Glu Gln Ala Val Glu Ala Ile Arg Lys Ala Gly 
             1220                1225                1230
Asn Pro Val Val Phe Met Val Gln Ser Ile Ile Asn Arg Pro Arg Lys 
         1235                1240                1245
Ser Pro Leu Pro Ser Leu Leu His Asn Leu Tyr Pro Lys Tyr Asn Phe 
     1250                1255                1260
Ser Ser Thr Asn Pro Phe Ala Asp Ser Leu Gln Ile Asn Ala Asp Lys 
 1265                1270                1275                1280
Ala Pro Ser Gln Ser Glu Ser Glu Pro Glu Lys Ala Pro Leu Cys Ser 
                 1285                1290                1295
Val Pro Pro Pro Pro Pro Ser Ala Phe Ala Glu Met Gly Ser Asp His 
             1300                1305                1310
Thr Gln Ser Ser Ala Ser Lys Ile Ser Gln Asp Val Asp Lys Glu Asp 
         1315                1320                1325
Glu Phe Gly Tyr Ser Trp Lys Asn Ile Arg Glu Arg Tyr Gly Thr Leu 
     1330                1335                1340
Thr Gly Glu Leu His Met Ile Glu Leu Glu Lys Gly His Ser Gly Leu 
 1345                1350                1355                1360
Gly Leu Ser Leu Ala Gly Asn Lys Asp Arg Ser Arg Met Ser Val Phe 
                 1365                1370                1375
Ile Val Gly Ile Asp Pro Asn Gly Ala Ala Gly Lys Asp Gly Arg Leu 
             1380                1385                1390
Gln Ile Ala Asp Glu Leu Leu Glu Ile Asn Gly Gln Ile Leu Tyr Gly 
         1395                1400                1405
Arg Ser His Gln Asn Ala Ser Ser Ile Ile Lys Cys Ala Pro Ser Lys 
     1410                1415                1420
Val Lys Ile Ile Phe Ile Arg Asn Lys Asp Ala Val Asn Gln Met Ala 
 1425                1430                1435                1440
Val Cys Pro Gly Asn Ala Val Glu Pro Leu Pro Ser Asn Ser Glu Asn 
                 1445                1450                1455
Leu Gln Asn Lys Glu Thr Glu Pro Thr Val Thr Thr Ser Asp Ala Ala 
             1460                1465                1470
Val Asp Leu Ser Ser Phe Lys Asn Val Gln His Leu Glu Leu Pro Lys 
         1475                1480                1485
Asp Gln Gly Gly Leu Gly Ile Ala Ile Ser Glu Glu Asp Thr Leu Ser 
     1490                1495                1500
Gly Val Ile Ile Lys Ser Leu Thr Glu His Gly Val Ala Ala Thr Asp 
 1505                1510                1515                1520
Gly Arg Leu Lys Val Gly Asp Gln Ile Leu Ala Val Asp Asp Glu Ile 
                 1525                1530                1535
Val Val Gly Tyr Pro Ile Glu Lys Phe Ile Ser Leu Leu Lys Thr Ala 
             1540                1545                1550
Lys Met Thr Val Lys Leu Thr Ile His Ala Glu Asn Pro Asp Ser Gln 
         1555                1560                1565
Ala Val Pro Ser Ala Ala Gly Ala Ala Ser Gly Glu Lys Lys Asn Ser 
     1570                1575                1580
Ser Gln Ser Leu Met Val Pro Gln Ser Gly Ser Pro Glu Pro Glu Ser 
 1585                1590                1595                1600
Ile Arg Asn Thr Ser Arg Ser Ser Thr Pro Ala Ile Phe Ala Ser Asp 
                 1605                1610                1615
Pro Ala Thr Cys Pro Ile Ile Pro Gly Cys Glu Thr Thr Ile Glu Ile 
             1620                1625                1630
Ser Lys Gly Arg Thr Gly Leu Gly Leu Ser Ile Val Gly Gly Ser Asp 
         1635                1640                1645
Thr Leu Leu Gly Ala Ile Ile Ile His Glu Val Tyr Glu Glu Gly Ala 
     1650                1655                1660
Ala Cys Lys Asp Gly Arg Leu Trp Ala Gly Asp Gln Ile Leu Glu Val 
 1665                1670                1675                1680
Asn Gly Ile Asp Leu Arg Lys Ala Thr His Asp Glu Ala Ile Asn Val 
                 1685                1690                1695
Leu Arg Gln Thr Pro Gln Arg Val Arg Leu Thr Leu Tyr Arg Asp Glu 
             1700                1705                1710
Ala Pro Tyr Lys Glu Glu Glu Val Cys Asp Thr Leu Thr Ile Glu Leu 
         1715                1720                1725
Gln Lys Lys Pro Gly Lys Gly Leu Gly Leu Ser Ile Val Gly Lys Arg 
     1730                1735                1740
Asn Asp Thr Gly Val Phe Val Ser Asp Ile Val Lys Gly Gly Ile Ala 
 1745                1750                1755                1760
Asp Ala Asp Gly Arg Leu Met Gln Gly Asp Gln Ile Leu Met Val Asn 
                 1765                1770                1775
Gly Glu Asp Val Arg Asn Ala Thr Gln Glu Ala Val Ala Ala Leu Leu 
             1780                1785                1790
Lys Cys Ser Leu Gly Thr Val Thr Leu Glu Val Gly Arg Ile Lys Ala 
         1795                1800                1805
Gly Ser Ser Thr Ser Glu Ser Leu Glu Ser Ser Ser Lys Lys Asn Ala 
     1810                1815                1820
Leu Ala Ser Glu Ile Gln Gly Leu Arg Thr Val Glu Met Lys Lys Gly 
 1825                1830                1835                1840
Pro Thr Asp Ser Leu Gly Ile Ser Ile Ala Gly Gly Val Gly Ser Pro 
                 1845                1850                1855
Leu Gly Asp Val Pro Ile Phe Ile Ala Met Met His Pro Thr Gly Val 
             1860                1865                1870
Ala Ala Gln Thr Gln Lys Leu Arg Val Gly Asp Arg Ile Val Thr Ile 
         1875                1880                1885
Cys Gly Thr Ser Thr Glu Gly Met Thr His Thr Gln Ala Val Asn Leu 
     1890                1895                1900
Leu Lys Asn Ala Ser Gly Ser Ile Glu Met Gln Val Val Ala Gly Gly 
 1905                1910                1915                1920
Asp Val Ser Val Val Thr Gly His Gln Gln Glu Pro Ala Ser Ser Ser 
                 1925                1930                1935
Leu Ser Phe Thr Gly Leu Thr Ser Ser Ser Ile Phe Gln Asp Asp Leu 
             1940                1945                1950
Gly Pro Pro Gln Cys Lys Ser Ile Thr Leu Glu Arg Gly Pro Asp Gly 
         1955                1960                1965
Leu Gly Phe Ser Ile Val Gly Gly Tyr Gly Ser Pro His Gly Asp Leu 
     1970                1975                1980
Pro Ile Tyr Val Lys Thr Val Phe Ala Lys Gly Ala Ala Ser Glu Asp 
 1985                1990                1995                2000
Gly Arg Leu Lys Arg Gly Asp Gln Ile Ile Ala Val Asn Gly Gln Ser 
                 2005                2010                2015
Leu Glu Gly Val Thr His Glu Glu Ala Val Ala Ile Leu Lys Arg Thr 
             2020                2025                2030
Lys Gly Thr Val Thr Leu Met Val Leu Ser 
         2035                2040



<210> 1352
<211> 8575
<212> DNA
<213> Rattus norvegicus
<308> AJ001713
<400> 1352

gaattcggc  cgagggcag  acagggagg  actgcggcg  agatacggg  cccacgggc  60
agagcagag  ccgcgattt  ggcggccgt  ccaacgcgt  ctctctggg  ggggtgcgg  120
gggggatgt  cctacccag  ccgggcgga  tctctctga  agggcgggg  atgcgcggc  180
gccgctctc  cggaccctg  ggcggctgg  cccaccctc  aggaaccat  ctacccccg  240
cggccttgg  ctctgcttt  tccggcctg  ccctggaaa  cgaggcggg  aagcggata  300
cgccgaaga  gaaggggct  tggtggcca  cgcggcgca  ccagagttc  tttgccaag  360
aaatggttt  cccagtcct  aacacatac  gtcctttct  atgggacaa  atccaatat  420
aatgtaagt  atggaggaa  acgacgctt  gaggataat  aacacacat  gcgaatata  480
cctgggaca  tttcagaag  aacaattta  tgtccaatt  ctgccagaa  aaactccac  540
gctgctgag  tgattgact  ccttataaa  agacttcac  tagacaaga  aaaatgcta  600
gttttagca  aggtaaagg  atttggtgg  gaagaatgg  ttctcaatc  aaccgactg  660
ccagttcag  gaatgatgc  gtggccccg  atggctttg  aaaatcgcc  aagtgggga  720
gactatcgc  ttcttctga  agaaaaaaa  ctcgatgga  caattcatt  tggtagcct  780
cagtcatgg  tacgggtaa  cgaagaacg  cgaaggatg  tggagcggg  ttttcttcc  840
cagcctcaa  agaaagact  tgatgattt  tgtagcttg  ctgatttga  tgagaaaac  900
ctcttagaa  acctacgga  tcgctttaa  catgaaaaa  tttatactt  tgttggcag  960
attctaata  ctattaatc  attcaaatt  cttcctatt  ataacccca  atatgtcaa  1020
atgtatgat  accaccagc  gggaaaact  gaaccccac  tatatgctg  ggcggatgt  1080
gcttatcat  ccatgcttc  gcgcaaaaa  aatcagtgt  ttgtgattt  aggagagag  1140
ggttctggg  agactcaaa  cacaaactt  cttattcat  accttactg  cctcagcca  1200
aaaggattt  ccagtggag  agaacagat  attcttgga  ctggaccag  acttgaggc  1260
tttggaaat  caaagacag  tcataataa  aattcaagt  gttttggca  gtttattca  1320
gtaaattac  aagaaacag  cactgtact  ggggcctat  ttgaaaaat  tcttctgga  1380
aaatctaga  ttgtttatc  agagcataa  gaacggaac  atcatgtat  ctattacct  1440
cttgcagga  caagtgaag  agagaggtt  gcattccac  ttaagcagc  tgaggagta  1500
cattttctc  accagataa  aaagaaacc  ctcagacag  gctgggatg  ttattgcta  1560
gattctgag  cggattgct  cacagtgga  ggagaagat  tgaggcatg  ttttgaacg  1620
ttacaattg  ccatggaaa  ggtaggatt  cttcccaag  cacgaagac  gattttctc  1680
ctgctctca  caatactac  tttgggtaa  atctcatat  aaaagaaga  ctatcgaga  1740
gactctatt  atatctgta  tcctgaagt  ctgcctatt  tctcagaat  actagaagt  1800
aaagaagag  tgctatttg  agcattggt  acaaggaag  cggtgacag  gggtgaaaa  1860
cttatttta  catataaac  ggcagaggc  gtgacagtg  gaaactcca  ggctaaatc  1920
ttatatagt  ctctgtttg  ctggatagt  tttcgtatt  atcatgcac  tctgaatag  1980
aaagatttg  aaaaagata  taagacttt  tccattggt  tacttgata  ttttgggtt  2040
gaagattat  aaaacaata  ttttgaaca  ttctgtatt  attttgcta  tgaacgttt  2100
cagcactac  ttaatcagc  tatctttaa  ttggagcaa  aggaatata  aactgaagg  2160
atcagttgg  acaacattg  ttatattga  aatacttgt  gtataaatc  tattagcaa  2220
aaaccaaca  gactgctcc  ccttttgga  gaagaaagc  actttccac  ggctacaaa  2280
caaacatta  ttgacaagt  taaacatca  catgaagag  attcttaca  tgaatttcc  2340
gctgtaatg  agcctgctt  tatcataaa  cattacgct  gaaaagtaa  atatggagt  2400
aaggatttt  gggaaaaaa  tacagatca  atgcgtcca  acattgtgg  tcttctgag  2460
agtagcagg  atgcttttg  ttctgggat  actggcatt  atcccgtag  tgttttccg  2520
tgggcagtt  tccgagcat  ttttagagc  gtggttgct  tcagggaag  tgggaaaag  2580
catattcag  gaaaaagtg  acatgatga  acaacacca  gtacaattt  gaaaagtat  2640
gatagtttt  gctttctcc  acacccagt  caccagagg  gcttagaga  tctgcagag  2700
tgcaaggaa  agaagtaca  tataacccg  aaaaaccca  gaacacctc  ttctgatct  2760
caaggcatg  acactctga  tgaaaaaaa  caacatgat  catttgata  tgcctggaa  2820
gtcagaact  gaattcgcc  aagcagact  ccaactaac  atacttcct  gcttgataa  2880
gatgggata  ttgctaatt  agcaagcag  aaactcctg  aaagagctc  tggaattct  2940
acgagaaac  aaaatttca  gtcaaaacc  gttcttcca  agcacttgc  ggaggtaaa  3000
tctttgaaa  atctgacca  actgaccct  caggatcga  ttaccaaat  tcttcttca  3060
ttgcataag  agaagaaac  tcccagtat  agcgcccag  ttcaggtct  cttaagcaa  3120
ctgatggag  cacttgatc  agcagaacc  tattttgta  aatgcattc  ctcaaatgc  3180
gaaaagctg  ccttaagat  cagtgatgc  ttggtacta  gacagcttc  gtacactgg  3240
atgctggag  cagttagaa  tcgccaatc  ggatatagc  ccaaatatt  tttccagga  3300
tttgtgagc  actttcatg  acttcttcc  caacatatt  tcccatcaa  atttaacat  3360
caagatttc  tcagaaaaa  aaatatcaa  cctgataat  atcaagttg  aaaaaccat  3420
gtgttccta  aggagcatg  acgacagca  ttacaggat  tgcttcatc  ggaagtgct  3480
cgcagaatc  tactgctgc  gcggtggtt  agggtcttg  tctctaggc  gcagttcct  3540
cacttgaga  aggcgtctg  tattattca  cgattctgg  ggaactatc  aaatcagaa  3600
caagttaga  atgcggctg  ggagaaaga  gctttcatc  tggctagtg  agcttccct  3660
cttcaagcg  cctggcgtg  tcacttaga  aggcagcgg  acttggagt  acgagctgc  3720
gctgtcatt  tccagcaga  atggaggga  ctctgtagg  gtagacaca  ggctgctac  3780
tgtatacag  caagatgga  gggctacag  caaagtaag  agtacaaag  acaaaggaa  3840
aaaattatc  tgttacagt  aatatatag  ggattcaga  cacgacaaa  atataaggc  3900
ttaaaagag  aaaggctga  agaaacaaa  ctagagcat  gattggcgc  gatcaagac  3960
tgtggacct  tagaaatcc  gggttcaga  ccttctgag  gggaggatc  ttcctttgc  4020
aacagagtg  aagccatag  agaatgtaa  tctgtgata  agagtaatc  aattagccg  4080
gagagttca  tggacttct  aaaggagtc  ccagacaag  aacaggaga  aggcaggag  4140
caaagtggt  cagatttac  gggggatgt  attgtaaga  agaggccca  gtcattgga  4200
gatctacat  agaaaaaag  aggtcgggc  aaaagagaa  gtcggagaa  gagagaatt  4260
gaacaagct  tatttagct  agaattgct  aaagtccgt  ctcttggtg  catgtctcc  4320
tcagaggaa  gtagatggt  tacagaatt  atgcctgaa  gccttcaat  tccacaggg  4380
acacctgat  gtgagagct  tcaagggag  ttagaactt  taacctgtg  tgagaacca  4440
aagagcaaa  cagagtccc  cattttaga  gatggagaa  tgaaaattt  atcacccag  4500
acatttacc  atccaaaat  tgattcaca  aataatgcc  tcagtgcct  aagtgagac  4560
agctctacg  tttctggaa  aggagcatc  tctgactca  agcatttga  gaatggaac  4620
gcagaggaa  agcttgtct  tagttctca  cccatcact  gtaaatctc  gctgagaga  4680
tcttttgtt  caagtagtc  gcctacatt  ttttatatt  ctcatcaag  acctctgaa  4740
acaagctcc  aactagata  aagtatcca  agaaacaaa  taccagaaa  agaaaccac  4800
ttgaagaca  ctcttactc  ggatattaa  agagaagcc  ggaagtgtc  gttttcagg  4860
caggtgact  ctttgaatc  agattcttc  tgtactgtg  ttaagaagc  agaaaagct  4920
aatattgaa  aggagaaaa  gcaaaagca  ttacagcag  agaatgaaa  agaaatgat  4980
gaacagatt  gtcagcaga  agatatttt  gagaaggaa  gcaaggctt  caagacaat  5040
gaacagtca  gaactgagg  ctctctctt  gcaccatcc  tttaccagt  aagacaaaa  5100
gtagagagg  catcttctc  gcatatcca  aatactcca  gtaagggag  agctggtgt  5160
ctaggttcc  catcagctc  tgccacaaa  gatagtccc  ccattcatt  acccccaaa  5220
gaccgacct  ttaccctgt  ctttgaaag  aaaggaagc  catgccaat  tagaactgt  5280
aaggaatta  ccaagacag  aagaatggg  acccaacat  atgctgcct  tagactctc  5340
aataatcac  atacagaaa  agaacactt  aagtcaact  actcttaca  ccacagatc  5400
gatgaccct  ccagagagg  aagttcgag  cctattttc  tcacaccaa  agacaatgt  5460
attactccc  ttgtacaca  tggaaatcc  caagtccac  aacaagatg  accagcttg  5520
aaatctaag  tagcagggc  tgggcaacg  gaggttgcc  gaccggccc  taaaaagaa  5580
gctcgaatg  cgcggacgc  ctccgattt  ttgactaga  gtacttttg  cgatgggga  5640
ggggataca  aggaagatg  ttacgatga  attattgag  cccttctct  ccttgacca  5700
gcttctcac  ctgagctag  gcctgtatc  agcctgggt  aggcctctc  cagtgactc  5760
gaaatgacg  cacaacgat  ttcttcagt  gatgaacaa  caaggcttc  taaggctat  5820
tctcaagga  agattacaa  attggcagg  cgacagaag  cttcagatt  ggacataag  5880
ccccagaga  cgaagatga  attctgggc  aaagggaaa  aaggagaga  gaagactac  5940
agagtaaaa  ctgctcccc  gtcggaggt  tcatcactc  ttgctggct  agatgtgac  6000
cctgttcat  cattttctg  tgagttaac  cagtaccac  caacacctc  tttgagtcc  6060
gaactgccc  ggagttgtc  aaaagagtt  aaagagaat  aggaaccat  gccaaaggc  6120
aaacgcaag  gaggtgtga  aatcagcag  gtggccttg  actctatgc  ctggcaaaa  6180
gactctgtc  aaatcatag  aagtgccaa  gatttaaaa  gtatggatg  gtttcttct  6240
aaaaagatg  atgacctag  taatgaaga  agcaagaag  atacattag  ggatgttgt  6300
tttaaaaaa  ccctcaaag  atttcggca  aatatcttc  gctcttact  gtctgcact  6360
gcgatggat  atgggaaaa  catacgcta  aaagatctg  atgcgctat  tgaacagat  6420
ctggaaaag  ccatgaggt  tgagcaacg  gattggaat  aatctccag  gagagtttg  6480
gttaacact  ttaaggtgt  tttagatga  tacatgaat  aattcaaga  tttggatag  6540
acagcccca  aggtgctta  aacagaaag  aagaaaagg  ggaaaaagg  aactgattt  6600
gtggaagag  acaatggcc  catgtttaa  gccacccag  acagcatcc  tacctactg  6660
gaatactgt  cttccttga  atggataat  gacagagcc  ctgtttgca  attgtgtaa  6720
tacgcttgc  ataagaagt  ctgtctgaa  accacagcc  agtgttcta  gaagtatga  6780
ccagagctg  catctcggc  atttggggt  gagctgtcc  gtctgacta  tgaagaccg  6840
gctgttcct  tagtggtag  gaagctcat  aactacatt  aaatgcatg  actttatac  6900
gagggtatt  accgaaagt  tggttcaac  aataaaatc  aggagcttc  acaaggtct  6960
gatacagat  ctgaaagtg  aaacctaga  gactataac  tacatgtca  tgcaagtgt  7020
ttcaaacaa  ggcttcgtg  tttgcccaa  ccactcatg  cttttgaac  ctatgaaga  7080
ttccttcga  ctatgggcc  tcaggaaag  aaggagaca  tccgtggtg  gtactctgt  7140
attgatcag  tctcccgga  tcacctcag  acactggaa  gccttatct  tcatctagt  7200
aggattgct  tacaggaag  cactaatag  atgtctgct  atgctttgg  catcgtgtt  7260
gcaccttgc  ttctccgtt  ccctgacac  actgaccca  tacaaagtg  tcaagatat  7320
agtaagact  ccacatgtg  ggaactgat  gttgtagaa  aaatgaata  atacaaggc  7380
cgtctcaaa  acatcagta  cctggaatt  gctgaaaat  aagcaaaga  cagactatc  7440
ctgattcgt  gatcaatga  acctgtcct  attgcagtt  gatttatga  cattacccg  7500
agttcagtc  cgggaaagg  gcgtctaca  cgaggaagc  atccaaatc  atcctcccc  7560
gttatagtc  gattgcctt  catgtctga  gtcccagaa  agaccttga  tagtgagac  7620
gccatggac  ctgacgtca  agaccagca  caagcagca  tgcagcagg  ggagaaagt  7680
ctgactgag  agattgaga  cctacagaa  gaaaaggaa  aactaacat  tgagatgct  7740
gtattggag  ctcgtgcct  tgatgatga  gcccttgag  ctgaggctt  tattgggac  7800
gctgatagc  cggaaaatt  gaatatgga  cctgaagag  gaagcttag  ccttagctc  7860
ctgaaagca  ctggcaagt  tgagccttc  agcaagttt  gaaagcagc  aagaaagca  7920
ccagactct  tggactcag  cagctcctc  gtttcttca  gtctatcaa  cactacatc  7980
tctcatggc  ctagaaagc  atttcagat  tattccaag  ctccatttt  ccgagctgc  8040
tcagcttgt  aggcccagg  aatggaagg  ccactaggc  aagccaaat  cctagaaga  8100
aggcctcag  tcatcagca  aggaacctt  aaccctgaa  agggcaaac  aaaactaaa  8160
aatgtgaaa  actcacctc  gaaaaccaa  gagacccca  aggggacgg  ttcatctgg  8220
cgaaagaaa  ctgtggact  agactgcag  tccacacag  aactaccac  gtttggaaa  8280
aatgagttt  tggtctaaa  ggacagaaa  gtctccaca  ctcatcttt  gggcctctt  8340
tggtcacct  gtttgtaac  gtcagtcct  atggtccta  cttgtcttc  gctgacagt  8400
tgtgtgctg  aacactgca  ttctggcaa  agtggcctc  ttgaagttt  ctagggatg  8460
gccagctgt  ccttggctg  tgtatttga  ttgagattc  actaaacaa  gccacctga  8520
acctgggtg  ttttggcca  cagtagttg  tctcgtgcc  aattcgata  cagct  8575



<210> 1353
<211> 2627
<212> PRT
<213> Rattus norvegicus
<308> AJ001713
<400> 1353

Met Asn Val Ser Asp Gly Gly Arg Arg Arg Phe Glu Asp Asn Glu His 
  1               5                  10                  15
Thr Leu Arg Ile Tyr Pro Gly Thr Ile Ser Glu Gly Thr Ile Tyr Cys 
             20                  25                  30
Pro Ile Pro Ala Arg Lys Asn Ser Thr Ala Ala Glu Val Ile Asp Ser 
         35                  40                  45
Leu Ile Asn Arg Leu His Leu Asp Lys Thr Lys Cys Tyr Val Leu Ala 
     50                  55                  60
Glu Val Lys Glu Phe Gly Gly Glu Glu Trp Ile Leu Asn Pro Thr Asp 
 65                  70                  75                  80
Cys Pro Val Gln Arg Met Met Leu Trp Pro Arg Met Ala Leu Glu Asn 
                 85                  90                  95
Arg Leu Ser Gly Glu Asp Tyr Arg Phe Leu Leu Arg Glu Lys Asn Leu 
             100                105                110
Asp Gly Ser Ile His Tyr Gly Ser Leu Gln Ser Trp Leu Arg Val Thr 
         115                120                125
Glu Glu Arg Arg Arg Met Met Glu Arg Gly Phe Leu Pro Gln Pro Gln 
     130                135                140
Gln Lys Asp Phe Asp Asp Leu Cys Ser Leu Pro Asp Leu Asn Glu Lys 
 145                150                155                160
Thr Leu Leu Glu Asn Leu Arg Asn Arg Phe Lys His Glu Lys Ile Tyr 
                 165                170                175
Thr Tyr Val Gly Ser Ile Leu Ile Ala Ile Asn Pro Phe Lys Phe Leu 
             180                185                190
Pro Ile Tyr Asn Pro Lys Tyr Val Lys Met Tyr Asp Asn His Gln Leu 
         195                200                205
Gly Lys Leu Glu Pro His Ile Tyr Ala Val Ala Asp Val Ala Tyr His 
     210                215                220
Ala Met Leu Gln Arg Lys Lys Asn Gln Cys Ile Val Ile Ser Gly Glu 
 225                230                235                240
Ser Gly Ser Gly Lys Thr Gln Ser Thr Asn Phe Leu Ile His His Leu 
                 245                250                255
Thr Ala Leu Ser Gln Lys Gly Phe Ala Ser Gly Val Glu Gln Ile Ile 
             260                265                270
Leu Gly Ala Gly Pro Val Leu Glu Ala Phe Gly Asn Ala Lys Thr Ala 
         275                280                285
His Asn Asn Asn Ser Ser Arg Phe Gly Lys Phe Ile Gln Val Asn Tyr 
     290                295                300
Gln Glu Thr Gly Thr Val Leu Gly Ala Tyr Val Glu Lys Tyr Leu Leu 
 305                310                315                320
Glu Lys Ser Arg Leu Val Tyr Gln Glu His Asn Glu Arg Asn Tyr His 
                 325                330                335
Val Phe Tyr Tyr Leu Leu Ala Gly Ala Ser Glu Glu Glu Arg Leu Ala 
             340                345                350
Phe His Leu Lys Gln Pro Glu Glu Tyr His Phe Leu Asn Gln Ile Thr 
         355                360                365
Lys Lys Pro Leu Arg Gln Ser Trp Asp Asp Tyr Cys Tyr Asp Ser Glu 
     370                375                380
Pro Asp Cys Phe Thr Val Glu Gly Glu Asp Leu Arg His Asp Phe Glu 
 385                390                395                400
Arg Leu Gln Leu Ala Met Glu Met Val Gly Phe Leu Pro Lys Thr Arg 
                 405                410                415
Arg Gln Ile Phe Ser Leu Leu Ser Ala Ile Leu His Leu Gly Asn Ile 
             420                425                430
Ser Tyr Lys Lys Lys Thr Tyr Arg Asp Asp Ser Ile Asp Ile Cys Asn 
         435                440                445
Pro Glu Val Leu Pro Ile Val Ser Glu Leu Leu Glu Val Lys Glu Glu 
     450                455                460
Met Leu Phe Glu Ala Leu Val Thr Arg Lys Thr Val Thr Val Gly Glu 
 465                470                475                480
Lys Leu Ile Leu Pro Tyr Lys Leu Ala Glu Ala Val Thr Val Arg Asn 
                 485                490                495
Ser Met Ala Lys Ser Leu Tyr Ser Ala Leu Phe Asp Trp Ile Val Phe 
             500                505                510
Arg Ile Asn His Ala Leu Leu Asn Ser Lys Asp Leu Glu Lys Asp Thr 
         515                520                525
Lys Thr Leu Ser Ile Gly Val Leu Asp Ile Phe Gly Phe Glu Asp Tyr 
     530                535                540
Glu Asn Asn Ser Phe Glu Gln Phe Cys Ile Asn Phe Ala Asn Glu Arg 
 545                550                555                560
Leu Gln His Tyr Phe Asn Gln His Ile Phe Lys Leu Glu Gln Glu Glu 
                 565                570                575
Tyr Arg Thr Glu Gly Ile Ser Trp His Asn Ile Asp Tyr Ile Asp Asn 
             580                585                590
Thr Cys Cys Ile Asn Leu Ile Ser Lys Lys Pro Thr Gly Leu Leu His 
         595                600                605
Leu Leu Asp Glu Glu Ser Asn Phe Pro Gln Ala Thr Asn Gln Thr Leu 
     610                615                620
Leu Asp Lys Phe Lys His Gln His Glu Glu Asn Ser Tyr Ile Glu Phe 
 625                630                635                640
Pro Ala Val Met Glu Pro Ala Phe Ile Ile Lys His Tyr Ala Gly Lys 
                 645                650                655
Val Lys Tyr Gly Val Lys Asp Phe Arg Glu Lys Asn Thr Asp His Met 
             660                665                670
Arg Pro Asp Ile Val Ala Leu Leu Arg Ser Ser Arg Asn Ala Phe Val 
         675                680                685
Ser Gly Met Thr Gly Ile Asp Pro Val Ala Val Phe Arg Trp Ala Val 
     690                695                700
Leu Arg Ala Phe Phe Arg Ala Val Val Ala Phe Arg Glu Ala Gly Lys 
 705                710                715                720
Arg His Ile Gln Arg Lys Ser Gly His Asp Asp Thr Thr Pro Cys Thr 
                 725                730                735
Ile Leu Lys Ser Met Asp Ser Phe Ser Phe Leu Gln His Pro Val His 
             740                745                750
Gln Arg Ser Leu Glu Ile Leu Gln Arg Cys Lys Glu Glu Lys Tyr Ser 
         755                760                765
Ile Thr Arg Lys Asn Pro Arg Thr Pro Leu Ser Asp Leu Gln Gly Met 
     770                775                780
Asn Thr Leu Asn Glu Lys Asn Gln His Asp Thr Phe Asp Ile Ala Trp 
 785                790                795                800
Asn Val Arg Thr Gly Ile Arg Gln Ser Arg Leu Pro Thr Asn Asn Thr 
                 805                810                815
Ser Leu Leu Asp Lys Asp Gly Ile Phe Ala Asn Ser Ala Ser Ser Lys 
             820                825                830
Leu Leu Glu Arg Ala His Gly Ile Leu Thr Arg Asn Lys Asn Phe Arg 
         835                840                845
Ser Lys Pro Val Leu Pro Lys His Leu Leu Glu Val Asn Ser Leu Lys 
     850                855                860
His Leu Thr Arg Leu Thr Leu Gln Asp Arg Ile Thr Lys Ser Leu Leu 
 865                870                875                880
His Leu His Lys Lys Lys Lys Pro Pro Ser Ile Ser Ala Gln Phe Gln 
                 885                890                895
Val Ser Leu Ser Lys Leu Met Glu Thr Leu Asp Gln Ala Glu Pro Tyr 
             900                905                910
Phe Val Lys Cys Ile Arg Ser Asn Ala Glu Lys Leu Pro Leu Arg Phe 
         915                920                925
Ser Asp Ala Leu Val Leu Arg Gln Leu Arg Tyr Thr Gly Met Leu Glu 
     930                935                940
Thr Val Arg Ile Arg Gln Ser Gly Tyr Ser Ser Lys Tyr Ser Phe Gln 
 945                950                955                960
Asp Phe Val Ser His Phe His Val Leu Leu Pro Gln His Ile Ile Pro 
                 965                970                975
Ser Lys Phe Asn Ile Gln Asp Phe Phe Arg Lys Ile Asn Ile Asn Pro 
             980                985                990
Asp Asn Tyr Gln Val Gly Lys Thr Met Val Phe Leu Lys Glu His Glu 
         995                1000                1005
Arg Gln His Leu Gln Asp Leu Leu His Gln Glu Val Leu Arg Arg Ile 
     1010                1015                1020
Ile Leu Leu Gln Arg Trp Phe Arg Val Leu Leu Ser Arg Gln Gln Phe 
 1025                1030                1035                1040
Leu His Leu Arg Gln Ala Ser Val Ile Ile Gln Arg Phe Trp Arg Asn 
                 1045                1050                1055
Tyr Leu Asn Gln Lys Gln Val Arg Asn Ala Ala Val Glu Lys Asp Ala 
             1060                1065                1070
Phe Ile Met Ala Ser Ala Ala Ser Leu Leu Gln Ala Ser Trp Arg Ala 
         1075                1080                1085
His Leu Glu Arg Gln Arg Tyr Leu Glu Leu Arg Ala Ala Ala Val Ile 
     1090                1095                1100
Ile Gln Gln Arg Trp Arg Glu Leu Cys Arg Arg Arg His Arg Ala Ala 
 1105                1110                1115                1120
Thr Cys Ile Gln Ser Arg Trp Arg Gly Tyr Arg Gln Ser Lys Lys Tyr 
                 1125                1130                1135
Lys Glu Gln Arg Asn Lys Ile Ile Leu Leu Gln Ser Ile Tyr Arg Gly 
             1140                1145                1150
Phe Arg Ala Arg Gln Arg Tyr Lys Ala Leu Lys Glu Glu Arg Leu Lys 
         1155                1160                1165
Glu Thr Lys Leu Glu His Gly Leu Ala Gln Ile Lys Thr Cys Gly Pro 
     1170                1175                1180
Leu Glu Ile Gln Gly Ser Asp Pro Ser Glu Trp Glu Asp Arg Ser Phe 
 1185                1190                1195                1200
Ala Asn Arg Val Lys Ala Ile Glu Glu Cys Lys Ser Val Ile Glu Ser 
                 1205                1210                1215
Asn Arg Ile Ser Arg Glu Ser Ser Met Asp Phe Ser Lys Glu Ser Pro 
             1220                1225                1230
Asp Lys Gln Gln Glu Arg Gly Arg Ser Gln Ser Gly Thr Asp Leu Gln 
         1235                1240                1245
Gly Asp Val Ile Val Arg Gln Arg Pro Lys Ser Leu Glu Asp Leu His 
     1250                1255                1260
Gln Lys Lys Val Gly Arg Ala Lys Arg Glu Ser Arg Arg Met Arg Glu 
 1265                1270                1275                1280
Leu Glu Gln Ala Ile Phe Ser Leu Glu Leu Leu Lys Val Arg Ser Leu 
                 1285                1290                1295
Gly Gly Met Ser Pro Ser Glu Glu Arg Arg Trp Ser Thr Glu Leu Met 
             1300                1305                1310
Pro Glu Gly Leu Gln Ser Pro Gln Gly Thr Pro Asp Ser Glu Ser Ser 
         1315                1320                1325
Gln Gly Ser Leu Glu Leu Leu Thr Cys Asp Glu Asn Gln Lys Ser Lys 
     1330                1335                1340
Pro Glu Ser Leu Ile Leu Asp Asp Gly Glu Leu Lys Ile Ser Ser Pro 
 1345                1350                1355                1360
Ser Thr Phe Thr Asn Pro Lys Phe Asp Ser Gln Asn Asn Ala Leu Ser 
                 1365                1370                1375
Ala Ser Ser Glu Thr Ser Ser Thr Phe Ser Gly Lys Gly Ala Ser Ser 
             1380                1385                1390
Asp Ser Glu His Leu Lys Asn Gly Thr Ala Glu Glu Lys Leu Val Tyr 
         1395                1400                1405
Ser Ser Gln Pro Ile Thr Cys Lys Ser Gln Leu Arg Asp Ser Phe Val 
     1410                1415                1420
Ser Ser Ser Leu Pro Thr Phe Phe Tyr Ile Pro His Gln Glu Pro Leu 
 1425                1430                1435                1440
Lys Thr Ser Ser Gln Leu Asp Thr Ser Ile Gln Arg Asn Lys Leu Pro 
                 1445                1450                1455
Glu Arg Glu Thr Thr Leu Lys Thr Thr Leu Thr Leu Asp Ile Asn Arg 
             1460                1465                1470
Glu Ala Arg Lys Cys Gln Phe Ser Gly Gln Val Thr Pro Leu Asn Pro 
         1475                1480                1485
Asp Ser Ser Cys Thr Val Leu Lys Lys Leu Glu Lys Leu Asn Ile Glu 
     1490                1495                1500
Lys Glu Lys Arg Gln Lys Gln Leu Gln Gln Gln Asn Glu Lys Glu Met 
 1505                1510                1515                1520
Met Glu Gln Ile Arg Gln Gln Thr Asp Ile Leu Glu Lys Glu Arg Lys 
                 1525                1530                1535
Ala Phe Lys Thr Ile Glu Gln Ser Arg Thr Glu Ala Ser Leu Leu Ala 
             1540                1545                1550
Pro Ser Phe Tyr Gln Ser Arg Gln Lys Val Glu Arg Pro Ser Ser Leu 
         1555                1560                1565
His Ile Gln Asn Thr Pro Ser Lys Gly Glu Ala Gly Val Leu Gly Ser 
     1570                1575                1580
Pro Ser Ala Leu Ala Thr Lys Asp Ser Pro Ser Ile His Leu Pro Pro 
 1585                1590                1595                1600
Lys Asp Arg Pro Val Thr Leu Phe Phe Glu Arg Lys Gly Ser Pro Cys 
                 1605                1610                1615
Gln Ser Arg Thr Val Lys Glu Leu Thr Lys Thr Glu Arg Met Gly Thr 
             1620                1625                1630
Gln His Asp Ala Ala Cys Arg Leu Ser Asn Asn His Asn Thr Glu Arg 
         1635                1640                1645
Glu His Phe Lys Ser Thr His Ser Tyr Ser His Arg Ser Asp Asp Pro 
     1650                1655                1660
Ser Arg Glu Gly Ser Ser Arg Pro Ile Phe Phe Thr Pro Lys Asp Asn 
 1665                1670                1675                1680
Val Ile Thr Pro Leu Val His Ser Gly Asn Pro Gln Val His Lys Gln 
                 1685                1690                1695
Asp Glu Pro Ala Trp Lys Ser Lys Leu Ala Gly Pro Gly Gln Arg Glu 
             1700                1705                1710
Val Ala Arg Pro Ala His Lys Lys Lys Ala Arg Met Ala Arg Thr Arg 
         1715                1720                1725
Ser Asp Phe Leu Thr Arg Gly Thr Phe Ala Asp Gly Glu Gly Asp Thr 
     1730                1735                1740
Glu Glu Asp Asp Tyr Asp Asp Ile Ile Glu Pro Leu Leu Ser Leu Asp 
 1745                1750                1755                1760
Gln Ala Ser His Ser Glu Leu Gly Pro Val Ser Ser Leu Gly Gln Ala 
                 1765                1770                1775
Ser His Ser Asp Ser Glu Met Thr Ser Gln Arg Phe Ser Ser Val Asp 
             1780                1785                1790
Glu Gln Ala Arg Leu His Lys Ala Met Ser Gln Gly Glu Ile Thr Lys 
         1795                1800                1805
Leu Ala Gly Arg Gln Lys Ser Ser Asp Leu Asp Ile Arg Pro Gln Arg 
     1810                1815                1820
Ala Lys Met Arg Phe Trp Ala Lys Gly Lys Gln Gly Glu Lys Lys Thr 
 1825                1830                1835                1840
Thr Arg Val Lys Pro Ala Pro Gln Ser Glu Val Ser Ser Leu Phe Ala 
                 1845                1850                1855
Gly Ser Asp Val Thr Pro Val His Pro Phe Ser Asp Glu Leu Thr Gln 
             1860                1865                1870
Tyr His Pro Thr Pro Pro Leu Ser Pro Glu Leu Pro Gly Ser Cys Arg 
         1875                1880                1885
Lys Glu Phe Lys Glu Asn Lys Glu Pro Ser Pro Lys Ala Lys Arg Lys 
     1890                1895                1900
Arg Gly Val Lys Ile Ser Ser Val Ala Leu Asp Ser Met His Trp Gln 
 1905                1910                1915                1920
Asn Asp Ser Val Gln Ile Ile Ala Ser Ala Asn Asp Leu Lys Ser Met 
                 1925                1930                1935
Asp Glu Phe Leu Leu Lys Lys Met Asn Asp Leu Asp Asn Glu Asp Ser 
             1940                1945                1950
Lys Lys Asp Thr Leu Val Asp Val Val Phe Lys Lys Ala Leu Lys Glu 
         1955                1960                1965
Phe Arg Gln Asn Ile Phe Ser Ser Tyr Ser Ser Ala Leu Ala Met Asp 
     1970                1975                1980
Asp Gly Lys Ser Ile Arg Tyr Lys Asp Leu Tyr Ala Leu Phe Glu Gln 
 1985                1990                1995                2000
Ile Leu Glu Lys Thr Met Arg Phe Glu Gln Arg Asp Trp Asn Glu Ser 
                 2005                2010                2015
Pro Val Arg Val Trp Val Asn Thr Phe Lys Val Phe Leu Asp Glu Tyr 
             2020                2025                2030
Met Asn Glu Phe Lys Thr Leu Asp Ser Thr Ala Pro Lys Val Leu Lys 
         2035                2040                2045
Thr Glu Arg Lys Lys Arg Arg Lys Lys Glu Thr Asp Leu Val Glu Glu 
     2050                2055                2060
His Asn Gly His Met Phe Lys Ala Thr Gln Tyr Ser Ile Pro Thr Tyr 
 2065                2070                2075                2080
Cys Glu Tyr Cys Ser Ser Leu Ile Trp Ile Met Asp Arg Ala Ser Val 
                 2085                2090                2095
Cys Lys Leu Cys Lys Tyr Ala Cys His Lys Lys Cys Cys Leu Lys Thr 
             2100                2105                2110
Thr Ala Lys Cys Ser Lys Lys Tyr Asp Pro Glu Leu Ser Ser Arg Gln 
         2115                2120                2125
Phe Gly Val Glu Leu Ser Arg Leu Thr Ser Glu Asp Arg Ala Val Pro 
     2130                2135                2140
Leu Val Val Glu Lys Leu Ile Asn Tyr Ile Glu Met His Gly Leu Tyr 
 2145                2150                2155                2160
Thr Glu Gly Ile Tyr Arg Lys Ser Gly Ser Thr Asn Lys Ile Lys Glu 
                 2165                2170                2175
Leu Arg Gln Gly Leu Asp Thr Asp Ala Glu Ser Val Asn Leu Asp Asp 
             2180                2185                2190
Tyr Asn Ile His Val Ile Ala Ser Val Phe Lys Gln Trp Leu Arg Asp 
         2195                2200                2205
Leu Pro Asn Pro Leu Met Thr Phe Glu Leu Tyr Glu Glu Phe Leu Arg 
     2210                2215                2220
Ala Met Gly Leu Gln Glu Arg Lys Glu Thr Ile Arg Gly Val Tyr Ser 
 2225                2230                2235                2240
Val Ile Asp Gln Leu Ser Arg Thr His Leu Ser Thr Leu Glu Arg Leu 
                 2245                2250                2255
Ile Phe His Leu Val Arg Ile Ala Leu Gln Glu Asp Thr Asn Arg Met 
             2260                2265                2270
Ser Ala Asn Ala Leu Ala Ile Val Phe Ala Pro Cys Ile Leu Arg Cys 
         2275                2280                2285
Pro Asp Thr Thr Asp Pro Leu Gln Ser Val Gln Asp Ile Ser Lys Thr 
     2290                2295                2300
Thr Thr Cys Val Glu Leu Ile Val Val Glu Gln Met Asn Lys Tyr Lys 
 2305                2310                2315                2320
Ala Arg Leu Lys Asp Ile Ser Ser Leu Glu Phe Ala Glu Asn Lys Ala 
                 2325                2330                2335
Lys Thr Arg Leu Ser Leu Ile Arg Arg Ser Met Lys Pro Val Leu Ile 
             2340                2345                2350
Ala Val Arg Phe Met Ser Ile Thr Arg Ser Ser Val Ser Gly Lys Gly 
         2355                2360                2365
Arg Leu His Arg Gly Ser His Pro Asn Pro Ser Ser Pro Val Ile Val 
     2370                2375                2380
Arg Leu Pro Ser Met Ser Asp Val Pro Glu Glu Thr Leu Thr Ser Glu 
 2385                2390                2395                2400
Thr Ala Met Asp Thr Asp Val Thr Asp Gln Gln Gln Ala Ala Met Gln 
                 2405                2410                2415
Gln Glu Glu Lys Val Leu Thr Glu Gln Ile Glu Asn Leu Gln Lys Glu 
             2420                2425                2430
Lys Glu Glu Leu Thr Phe Glu Met Leu Val Leu Glu Pro Arg Ala Ser 
         2435                2440                2445
Asp Asp Glu Ala Leu Glu Ser Glu Ala Ser Ile Gly Thr Ala Asp Ser 
     2450                2455                2460
Ser Glu Asn Leu Asn Met Asp Pro Glu Glu Arg Ser Leu Ala Leu Ser 
 2465                2470                2475                2480
Ser Leu Lys Ala Ala Gly Lys Ser Glu Pro Ser Ser Lys Phe Arg Lys 
                 2485                2490                2495
Gln Leu Arg Lys Gln Pro Asp Ser Leu Asp Ser Val Ser Ser Ser Val 
             2500                2505                2510
Ser Ser Cys Leu Ser Asn Thr Thr Ser Ser His Gly Thr Arg Lys Arg 
         2515                2520                2525
Phe Gln Ile Tyr Ser Lys Ser Pro Phe Tyr Arg Ala Ala Ser Ala Cys 
     2530                2535                2540
Glu Ala Gln Gly Met Glu Gly Pro Leu Gly Gln Ala Lys Ser Leu Glu 
 2545                2550                2555                2560
Asp Arg Pro Gln Phe Ile Ser Arg Gly Thr Phe Asn Pro Glu Lys Gly 
                 2565                2570                2575
Lys Gln Lys Leu Lys Asn Val Lys Asn Ser Pro Gln Lys Thr Lys Glu 
             2580                2585                2590
Thr Pro Glu Gly Thr Val Ser Ser Gly Arg Lys Lys Thr Val Asp Ser 
         2595                2600                2605
Asp Cys Ser Ser Thr Gln Gln Leu Pro Leu Phe Gly Asn Asn Glu Phe 
     2610                2615                2620
Met Val Ter 
 2625



<210> 1354
<211> 2257
<212> DNA
<213> Homo sapiens
<308> AK001923
<400> 1354

aaagaaaag  aggaaaaag  aaactgatt  ggtggaaga  cacaatggt  acatcttta  60
agccaccca  tatagcatc  ctacatact  tgaatactg  tcttctttg  tatggataa  120
ggaccgagc  tctgtttgc  aattatgca  gtatgcttg  cataagaag  gctgtctga  180
aaccacagc  aagtgctct  aaaagtatg  tccagagct  tcatctcga  aatttgggg  240
tgaactgtc  cgtttgacc  gtgaagacc  aactgttcc  ttagtagtg  aaaagctca  300
aaactacat  gaaatgcat  gactgtata  agaaggtat  tatcgaaag  ctggttcga  360
taataaaat  aaggagctt  ggcagggtc  agatacaga  gctgagagt  taaatctag  420
tgactataa  atacacgtc  ttgcaagtg  attcaaaca  tggcttcga  atttgccca  480
tcctctcat  acctttgaa  tctatgagg  atttcttcg  gctatgggc  ttcaggaga  540
gaaggagac  atccgtggt  tatactctg  gattgatca  ctctcccga  ctcatctca  600
tacactgga  cgcctcatc  ttcatctag  caggattgc  ctgcaggaa  acactaatc  660
aatgtctgc  aatgctttg  ccattgtgt  tgcgccctg  attctccgc  gccctgaca  720
cactgaccc  ctacaaagt  tacaggaca  cagtaagac  accacttgt  tggaactga  780
tgttgtgga  caaatgaat  aatacaagg  tcgtctcaa  gatatcagt  gcttggaat  840
tgctgagaa  aaggcaaag  ccaggttgt  actgattcg  agatcaatg  gaaaggggc  900
tattcgtcg  ggaaactat  caggtccat  gtctcctgt  gtagttcgg  tgccttctg  960
gtctgatgt  tcagaggag  ccttgacta  tgaggcagc  atggagact  acatcacag  1020
acagcagca  gcagctatg  agcaggagg  gagagtact  actgagcag  ttgagaacc  1080
acagaagga  aaggaggag  taacatttg  gatgcttgt  ctggaaccc  gtgcctctg  1140
tgatgaaac  cttgagtct  aggcctcca  tgggactgc  gatagctca  agaatttga  1200
tatggagtc  gaatatgct  tctctgaga  atcagaaag  agcttagcc  ttagctccc  1260
gaagacagc  ggcaagtct  aaccttcca  caagttgcg  aagcaactt  aaaagcagc  1320
agactcttt  gatgtcgtg  actcttcgg  ctcctcttt  tgtctgtct  acacggcat  1380
atctcatgg  accagaaaa  tatttcaga  ttattccaa  tctccattc  accgagctg  1440
ctcaggtaa  gaggccctg  gaatggaag  accattggg  cagaccaaa  tcctggaag  1500
caagcctca  ttcatcagc  gaggaacct  caacccgga  aagggcaaa  aaaaattaa  1560
gaatgtgaa  aactcacct  agaaaacca  agagacccc  gaggggaca  tcatgtctg  1620
ccgcagaaa  actgtggac  cagactgca  ctccaacca  cagctagca  tctttggaa  1680
taatgaatt  atggtctga  ccggcagat  tgtgtccct  cgtggctac  gagtggtaa  1740
caaatctca  ctttggggc  gcgtttcat  acctcgtcc  caatagtca  tcctaattg  1800
ggtcctgcc  cttttctaa  catatggct  agactgtat  tgctgaatt  ctgggcctc  1860
tgcagaagc  gaaagcctg  tggggatgg  gccagctgt  ccttggctg  tgtatttga  1920
ttgagattt  tactataca  agccaccta  ggcctgggg  tttgggtca  ttgtagttg  1980
ctctccccc  ccctctttt  ccttcccaa  ggtgggtgt  gaactaggg  ggatattgc  2040
gtcctgagg  accctctca  ttctgacat  tgaagaaaa  gtataaatc  ttcttaacc  2100
tgaaagcaa  agcctttgg  tttattttg  gatagttag  agctagggt  gaatataat  2160
tttttccaa  aacttactt  caaacaaaa  gcctaatcc  tctatttta  gatttctgg  2220
aaaacactc  atgttatat  ctggggaaa  caaaaac  2257



<210> 1355
<211> 2548
<212> PRT
<213> Homo sapiens
<308> NP_008832
<400> 1355

Met Asn Ile Asn Asp Gly Gly Arg Arg Arg Phe Glu Asp Asn Glu His 
  1               5                  10                  15
Thr Leu Arg Ile Tyr Pro Gly Ala Ile Ser Glu Gly Thr Ile Tyr Cys 
             20                  25                  30
Pro Ile Pro Ala Arg Lys Asn Ser Thr Ala Ala Glu Val Ile Glu Ser 
         35                  40                  45
Leu Ile Asn Lys Leu His Leu Asp Lys Thr Lys Cys Tyr Val Leu Ala 
     50                  55                  60
Glu Val Lys Glu Phe Gly Gly Glu Glu Trp Ile Leu Asn Pro Thr Asp 
 65                  70                  75                  80
Cys Pro Val Gln Gln Met Met Leu Trp Pro Arg Met Ala Leu Glu Asn 
                 85                  90                  95
Arg Leu Ser Gly Glu Asp Tyr Arg Phe Leu Leu Arg Glu Lys Asn Leu 
             100                105                110
Asp Gly Ser Ile His Tyr Gly Ser Leu Gln Ser Trp Leu Arg Val Thr 
         115                120                125
Glu Glu Arg Arg Arg Met Met Glu Arg Gly Phe Leu Pro Gln Pro Gln 
     130                135                140
Gln Lys Asp Phe Asp Asp Leu Cys Ser Leu Pro Asp Leu Asn Glu Lys 
 145                150                155                160
Thr Leu Leu Glu Asn Leu Arg Asp Arg Phe Lys His Glu Lys Ile Tyr 
                 165                170                175
Thr Tyr Val Gly Ser Ile Leu Ile Val Ile Asn Pro Phe Lys Phe Leu 
             180                185                190
Pro Ile Tyr Asn Pro Lys Tyr Val Lys Met Tyr Asp Asn His Gln Leu 
         195                200                205
Gly Lys Pro Glu Pro His Ile Tyr Ala Val Ala Asp Val Ala Tyr His 
     210                215                220
Ala Met Leu Gln Arg Lys Lys Asn Gln Cys Ile Val Ile Ser Gly Glu 
 225                230                235                240
Ser Gly Ser Gly Lys Thr Gln Ser Thr Asn Phe Leu Ile His His Leu 
                 245                250                255
Thr Ala Leu Ser Gln Lys Gly Phe Ala Ser Gly Val Glu Gln Ile Ile 
             260                265                270
Leu Gly Ala Gly Pro Val Leu Glu Ala Phe Gly Asn Ala Lys Thr Ala 
         275                280                285
His Asn Asn Asn Ser Ser Arg Phe Gly Lys Phe Ile Gln Val Asn Tyr 
     290                295                300
Gln Glu Thr Gly Thr Val Leu Gly Ala Tyr Val Glu Lys Tyr Leu Leu 
 305                310                315                320
Glu Lys Ser Arg Leu Val Tyr Gln Glu His Asn Glu Arg Asn Tyr His 
                 325                330                335
Val Phe Tyr Tyr Leu Leu Ala Gly Ala Ser Glu Asp Glu Arg Ser Ala 
             340                345                350
Phe His Leu Lys Gln Pro Glu Glu Tyr His Tyr Leu Asn Gln Ile Thr 
         355                360                365
Lys Lys Pro Leu Arg Gln Ser Trp Asp Asp Tyr Cys Tyr Asp Ser Glu 
     370                375                380
Pro Asp Cys Phe Thr Val Glu Gly Glu Asp Leu Arg His Asp Phe Glu 
 385                390                395                400
Arg Leu Gln Leu Ala Met Glu Met Val Gly Phe Leu Pro Lys Thr Arg 
                 405                410                415
Arg Gln Ile Phe Ser Leu Leu Ser Ala Ile Leu His Leu Gly Asn Ile 
             420                425                430
Cys Tyr Lys Lys Lys Thr Tyr Arg Asp Asp Ser Ile Asp Ile Cys Asn 
         435                440                445
Pro Glu Val Leu Pro Ile Val Ser Glu Leu Leu Glu Val Lys Glu Glu 
     450                455                460
Met Leu Phe Glu Ala Leu Val Thr Arg Lys Thr Val Thr Val Gly Glu 
 465                470                475                480
Lys Leu Ile Leu Pro Tyr Lys Leu Ala Glu Ala Val Thr Val Arg Asn 
                 485                490                495
Ser Met Ala Lys Ser Leu Tyr Ser Ala Leu Phe Asp Trp Ile Val Phe 
             500                505                510
Arg Ile Asn His Ala Leu Leu Asn Ser Lys Asp Leu Glu His Asn Thr 
         515                520                525
Lys Thr Leu Ser Ile Gly Val Leu Asp Ile Phe Gly Phe Glu Asp Tyr 
     530                535                540
Glu Asn Asn Ser Phe Glu Gln Phe Cys Ile Asn Phe Ala Asn Glu Arg 
 545                550                555                560
Leu Gln His Tyr Phe Asn Gln His Ile Phe Lys Leu Glu Gln Glu Glu 
                 565                570                575
Tyr Arg Thr Glu Gly Ile Ser Trp His Asn Ile Asp Tyr Ile Asp Asn 
             580                585                590
Thr Cys Cys Ile Asn Leu Ile Ser Lys Lys Pro Thr Gly Leu Leu His 
         595                600                605
Leu Leu Asp Glu Glu Ser Asn Phe Pro Gln Ala Thr Asn Gln Thr Leu 
     610                615                620
Leu Asp Lys Phe Lys His Gln His Glu Asp Asn Ser Tyr Ile Glu Phe 
 625                630                635                640
Pro Ala Val Met Glu Pro Ala Phe Ile Ile Lys His Tyr Ala Gly Lys 
                 645                650                655
Val Lys Tyr Gly Val Lys Asp Phe Arg Glu Lys Asn Thr Asp His Met 
             660                665                670
Arg Pro Asp Ile Val Ala Leu Leu Arg Ser Ser Lys Asn Ala Phe Ile 
         675                680                685
Ser Gly Met Ile Gly Ile Asp Pro Val Ala Val Phe Arg Trp Ala Ile 
     690                695                700
Leu Arg Ala Phe Phe Arg Ala Met Val Ala Phe Arg Glu Ala Gly Lys 
 705                710                715                720
Arg Asn Ile His Arg Lys Thr Gly His Asp Asp Thr Ala Pro Cys Ala 
                 725                730                735
Ile Leu Lys Ser Met Asp Ser Phe Ser Phe Leu Gln His Pro Val His 
             740                745                750
Gln Arg Ser Leu Glu Ile Leu Gln Arg Cys Lys Glu Glu Lys Tyr Ser 
         755                760                765
Ile Thr Arg Lys Asn Pro Arg Thr Pro Leu Ser Asp Leu Gln Gly Met 
     770                775                780
Asn Ala Leu Asn Glu Lys Asn Gln His Asp Thr Phe Asp Ile Ala Trp 
 785                790                795                800
Asn Gly Arg Thr Gly Ile Arg Gln Ser Arg Leu Ser Ser Gly Thr Ser 
                 805                810                815
Leu Leu Asp Lys Asp Gly Ile Phe Ala Asn Ser Thr Ser Ser Lys Leu 
             820                825                830
Leu Glu Arg Ala His Gly Ile Leu Thr Arg Asn Lys Asn Phe Lys Ser 
         835                840                845
Lys Pro Ala Leu Pro Lys His Leu Leu Glu Val Asn Ser Leu Lys His 
     850                855                860
Leu Thr Arg Leu Thr Leu Gln Asp Arg Ile Thr Lys Ser Leu Leu His 
 865                870                875                880
Leu His Lys Lys Lys Lys Pro Pro Ser Ile Ser Ala Gln Phe Gln Ala 
                 885                890                895
Ser Leu Ser Lys Leu Met Glu Thr Leu Gly Gln Ala Glu Pro Tyr Phe 
             900                905                910
Val Lys Cys Ile Arg Ser Asn Ala Glu Lys Leu Pro Leu Arg Phe Ser 
         915                920                925
Asp Val Leu Val Leu Arg Gln Leu Arg Tyr Thr Gly Met Leu Glu Thr 
     930                935                940
Val Gln Ile Arg Gln Ser Gly Tyr Ser Ser Lys Tyr Ser Phe Gln Asp 
 945                950                955                960
Phe Val Ser His Phe His Val Leu Leu Pro Arg Asn Ile Ile Pro Ser 
                 965                970                975
Lys Phe Asn Ile Gln Asp Phe Phe Arg Lys Ile Asn Leu Asn Pro Asp 
             980                985                990
Asn Tyr Gln Val Gly Lys Thr Met Val Phe Leu Lys Glu Gln Glu Arg 
         995                1000                1005
Gln His Leu Gln Asp Leu Leu His Gln Glu Val Leu Arg Arg Ile Ile 
     1010                1015                1020
Leu Leu Gln Arg Trp Phe Arg Val Leu Leu Cys Arg Gln His Phe Leu 
 1025                1030                1035                1040
His Leu Arg Gln Ala Ser Val Ile Ile Gln Arg Phe Trp Arg Asn Tyr 
                 1045                1050                1055
Leu Asn Gln Lys Gln Val Arg Asp Ala Ala Val Gln Lys Asp Ala Phe 
             1060                1065                1070
Val Met Ala Ser Ala Ala Ala Leu Leu Gln Ala Ser Trp Arg Ala His 
         1075                1080                1085
Leu Glu Arg Gln Arg Tyr Leu Glu Leu Arg Ala Ala Ala Ile Val Ile 
     1090                1095                1100
Gln Gln Lys Trp Arg Asp Tyr Tyr Arg Arg Arg His Met Ala Ala Ile 
 1105                1110                1115                1120
Cys Ile Gln Ala Arg Trp Lys Ala Tyr Arg Glu Ser Lys Arg Tyr Gln 
                 1125                1130                1135
Glu Gln Arg Lys Lys Ile Ile Leu Leu Gln Ser Thr Cys Arg Gly Phe 
             1140                1145                1150
Arg Ala Arg Gln Arg Phe Lys Ala Leu Lys Glu Gln Arg Leu Arg Glu 
         1155                1160                1165
Thr Lys Pro Glu Val Gly Leu Val Asn Ile Lys Gly Tyr Gly Ser Leu 
     1170                1175                1180
Glu Ile Gln Gly Ser Asp Pro Ser Glu Trp Glu Asp Cys Ser Phe Asp 
 1185                1190                1195                1200
Asn Arg Ile Lys Ala Ile Glu Glu Cys Lys Ser Val Ile Glu Ser Asn 
                 1205                1210                1215
Arg Ile Ser Arg Glu Ser Ser Val Asp Cys Leu Lys Glu Ser Pro Asn 
             1220                1225                1230
Lys Gln Gln Glu Arg Ala Gln Ser Gln Ser Gly Val Asp Leu Gln Glu 
         1235                1240                1245
Asp Val Leu Val Arg Glu Arg Pro Arg Ser Leu Glu Asp Leu His Gln 
     1250                1255                1260
Lys Lys Val Gly Arg Ala Lys Arg Glu Ser Arg Arg Met Arg Glu Leu 
 1265                1270                1275                1280
Glu Gln Ala Ile Phe Ser Leu Glu Leu Leu Lys Val Arg Ser Leu Gly 
                 1285                1290                1295
Gly Ile Ser Pro Ser Glu Asp Arg Arg Trp Ser Thr Glu Leu Val Pro 
             1300                1305                1310
Glu Gly Leu Gln Ser Pro Arg Gly Thr Pro Asp Ser Glu Ser Ser Gln 
         1315                1320                1325
Gly Ser Leu Glu Leu Leu Ser Tyr Glu Glu Ser Gln Lys Ser Lys Leu 
     1330                1335                1340
Glu Ser Val Ile Ser Asp Glu Gly Asp Leu Gln Phe Pro Ser Pro Lys 
 1345                1350                1355                1360
Ile Ser Ser Ser Pro Lys Phe Asp Ser Arg Asp Asn Ala Leu Ser Ala 
                 1365                1370                1375
Ser Asn Glu Thr Ser Ser Ala Glu His Leu Lys Asp Gly Thr Met Lys 
             1380                1385                1390
Glu Met Val Val Cys Ser Ser Glu Ser Ile Thr Cys Lys Pro Gln Leu 
         1395                1400                1405
Lys Asp Ser Phe Ile Ser Asn Ser Leu Pro Thr Phe Phe Tyr Ile Pro 
     1410                1415                1420
Gln Gln Asp Pro Leu Lys Thr Asn Ser Gln Leu Asp Thr Ser Ile Gln 
 1425                1430                1435                1440
Arg Asn Lys Leu Leu Glu Asn Glu Asp Thr Ala Gly Glu Ala Leu Thr 
                 1445                1450                1455
Leu Asp Ile Asn Arg Glu Thr Arg Arg Tyr His Cys Ser Gly Lys Asp 
             1460                1465                1470
Gln Ile Val Pro Ser Leu Asn Thr Glu Ser Ser Asn Pro Val Leu Lys 
         1475                1480                1485
Lys Leu Glu Lys Leu Asn Thr Glu Lys Glu Glu Arg Gln Lys Gln Leu 
     1490                1495                1500
Gln Gln Gln Asn Glu Lys Glu Met Met Glu Gln Ile Arg Gln Gln Thr 
 1505                1510                1515                1520
Asp Ile Leu Glu Lys Glu Arg Lys Ala Phe Lys Thr Ile Glu Lys Pro 
                 1525                1530                1535
Arg Ile Gly Glu Cys Leu Val Ala Pro Ser Ser Tyr Gln Ser Lys Gln 
             1540                1545                1550
Arg Val Glu Arg Pro Ser Ser Leu Leu Ser Leu Asn Thr Ser Asn Lys 
         1555                1560                1565
Gly Glu Leu Asn Val Leu Gly Ser Leu Ser Leu Lys Asp Ala Ala Leu 
     1570                1575                1580
Ala Gln Lys Asp Ser Ser Ser Ala His Leu Pro Pro Lys Asp Arg Pro 
 1585                1590                1595                1600
Val Thr Val Phe Phe Glu Arg Lys Gly Ser Pro Cys Gln Ser Ser Thr 
                 1605                1610                1615
Val Lys Glu Leu Ser Lys Thr Asp Arg Met Gly Thr Gln Leu Asn Val 
             1620                1625                1630
Ala Cys Lys Leu Ser Asn Asn Arg Ile Ser Lys Arg Glu His Phe Arg 
         1635                1640                1645
Pro Thr Gln Ser Tyr Ser His Asn Ser Asp Asp Leu Ser Arg Glu Gly 
     1650                1655                1660
Asn Ala Arg Pro Ile Phe Phe Thr Pro Lys Asp Asn Met Ser Ile Pro 
 1665                1670                1675                1680
Leu Val Ser Lys Glu Ala Leu Asn Ser Lys Asn Pro Gln Leu His Lys 
                 1685                1690                1695
Glu Asp Glu Pro Ala Trp Lys Pro Val Lys Leu Ala Gly Pro Gly Gln 
             1700                1705                1710
Arg Glu Thr Ser Gln Arg Phe Ser Ser Val Asp Glu Gln Ala Lys Leu 
         1715                1720                1725
His Lys Thr Met Ser Gln Gly Glu Ile Thr Lys Leu Ala Val Arg Gln 
     1730                1735                1740
Lys Ala Ser Asp Ser Asp Ile Arg Pro Gln Arg Ala Lys Met Arg Phe 
 1745                1750                1755                1760
Trp Ala Lys Gly Lys Gln Gly Glu Lys Lys Thr Thr Arg Val Lys Pro 
                 1765                1770                1775
Thr Thr Gln Ser Glu Val Ser Pro Leu Phe Ala Gly Thr Asp Val Ile 
             1780                1785                1790
Pro Ala His Gln Phe Pro Asp Glu Leu Ala Ala Tyr His Pro Thr Pro 
         1795                1800                1805
Pro Leu Ser Pro Glu Leu Pro Gly Ser Cys Arg Lys Glu Phe Lys Glu 
     1810                1815                1820
Asn Lys Glu Pro Ser Pro Lys Ala Lys Arg Lys Arg Ser Val Lys Ile 
 1825                1830                1835                1840
Ser Asn Val Ala Leu Asp Ser Met His Trp Gln Asn Asp Ser Val Gln 
                 1845                1850                1855
Ile Ile Ala Ser Val Ser Asp Leu Lys Ser Met Asp Glu Phe Leu Leu 
             1860                1865                1870
Lys Lys Val Asn Asp Leu Asp Asn Glu Asp Ser Lys Lys Asp Thr Leu 
         1875                1880                1885
Val Asp Val Val Phe Lys Lys Ala Leu Lys Glu Phe Arg Gln Asn Ile 
     1890                1895                1900
Phe Ser Phe Tyr Ser Ser Ala Leu Ala Met Asp Asp Gly Lys Ser Ile 
 1905                1910                1915                1920
Arg Tyr Lys Asp Leu Tyr Ala Leu Phe Glu Gln Ile Leu Glu Lys Thr 
                 1925                1930                1935
Met Arg Leu Glu Gln Arg Asp Ser Leu Gly Glu Ser Pro Val Arg Val 
             1940                1945                1950
Trp Val Asn Thr Phe Lys Val Phe Leu Asp Glu Tyr Met Asn Glu Phe 
         1955                1960                1965
Lys Thr Ser Asp Cys Thr Ala Thr Lys Val Pro Lys Thr Glu Arg Lys 
     1970                1975                1980
Lys Arg Arg Lys Lys Glu Thr Asp Leu Val Glu Glu His Asn Gly His 
 1985                1990                1995                2000
Ile Phe Lys Ala Thr Gln Tyr Ser Ile Pro Thr Tyr Cys Glu Tyr Cys 
                 2005                2010                2015
Ser Ser Leu Ile Trp Ile Met Asp Arg Ala Ser Val Cys Lys Leu Cys 
             2020                2025                2030
Lys Tyr Ala Cys His Lys Lys Cys Cys Leu Lys Thr Thr Ala Lys Cys 
         2035                2040                2045
Ser Lys Lys Tyr Asp Pro Glu Leu Ser Ser Arg Gln Phe Gly Val Glu 
     2050                2055                2060
Leu Ser Arg Leu Thr Ser Glu Asp Arg Thr Val Pro Leu Val Val Glu 
 2065                2070                2075                2080
Lys Leu Ile Asn Tyr Ile Glu Met His Gly Leu Tyr Thr Glu Gly Ile 
                 2085                2090                2095
Tyr Arg Lys Ser Gly Ser Thr Asn Lys Ile Lys Glu Leu Arg Gln Gly 
             2100                2105                2110
Leu Asp Thr Asp Ala Glu Ser Val Asn Leu Asp Asp Tyr Asn Ile His 
         2115                2120                2125
Val Ile Ala Ser Val Phe Lys Gln Trp Leu Arg Asp Leu Pro Asn Pro 
     2130                2135                2140
Leu Met Thr Phe Glu Leu Tyr Glu Glu Phe Leu Arg Ala Met Gly Leu 
 2145                2150                2155                2160
Gln Glu Arg Lys Glu Thr Ile Arg Gly Val Tyr Ser Val Ile Asp Gln 
                 2165                2170                2175
Leu Ser Arg Thr His Leu Asn Thr Leu Glu Arg Leu Ile Phe His Leu 
             2180                2185                2190
Val Arg Ile Ala Leu Gln Glu Asp Thr Asn Arg Met Ser Ala Asn Ala 
         2195                2200                2205
Leu Ala Ile Val Phe Ala Pro Cys Ile Leu Arg Cys Pro Asp Thr Thr 
     2210                2215                2220
Asp Pro Leu Gln Ser Val Gln Asp Ile Ser Lys Thr Thr Thr Cys Val 
 2225                2230                2235                2240
Glu Leu Ile Val Val Glu Gln Met Asn Lys Tyr Lys Ala Arg Leu Lys 
                 2245                2250                2255
Asp Ile Ser Ser Leu Glu Phe Ala Glu Asn Lys Ala Lys Thr Arg Leu 
             2260                2265                2270
Ser Leu Ile Arg Arg Ser Met Gly Lys Gly Arg Ile Arg Arg Gly Asn 
         2275                2280                2285
Tyr Pro Gly Pro Ser Ser Pro Val Val Val Arg Leu Pro Ser Val Ser 
     2290                2295                2300
Asp Val Ser Glu Glu Thr Leu Thr Ser Glu Ala Ala Met Glu Thr Asp 
 2305                2310                2315                2320
Ile Thr Glu Gln Gln Gln Ala Ala Met Gln Gln Glu Glu Arg Val Leu 
                 2325                2330                2335
Thr Glu Gln Ile Glu Asn Leu Gln Lys Glu Lys Glu Glu Leu Thr Phe 
             2340                2345                2350
Glu Met Leu Val Leu Glu Pro Arg Ala Ser Asp Asp Glu Thr Leu Glu 
         2355                2360                2365
Ser Glu Ala Ser Ile Gly Thr Ala Asp Ser Ser Glu Asn Leu Asn Met 
     2370                2375                2380
Glu Ser Glu Tyr Ala Ile Ser Glu Lys Ser Glu Arg Ser Leu Ala Leu 
 2385                2390                2395                2400
Ser Ser Leu Lys Thr Ala Gly Lys Ser Glu Pro Ser Ser Lys Leu Arg 
                 2405                2410                2415
Lys Gln Leu Lys Lys Gln Gln Asp Ser Leu Asp Val Val Asp Ser Ser 
             2420                2425                2430
Val Ser Ser Leu Cys Leu Ser Asn Thr Ala Ser Ser His Gly Thr Arg 
         2435                2440                2445
Lys Leu Phe Gln Ile Tyr Ser Lys Ser Pro Phe Tyr Arg Ala Ala Ser 
     2450                2455                2460
Gly Asn Glu Ala Leu Gly Met Glu Gly Pro Leu Gly Gln Thr Lys Phe 
 2465                2470                2475                2480
Leu Glu Asp Lys Pro Gln Phe Ile Ser Arg Gly Thr Phe Asn Pro Glu 
                 2485                2490                2495
Lys Gly Lys Gln Lys Leu Lys Asn Val Lys Asn Ser Pro Gln Lys Thr 
             2500                2505                2510
Lys Glu Thr Pro Glu Gly Thr Val Met Ser Gly Arg Arg Lys Thr Val 
         2515                2520                2525
Asp Pro Asp Cys Thr Ser Asn Gln Gln Leu Ala Leu Phe Gly Asn Asn 
     2530                2535                2540
Glu Phe Met Val 
 2545



<210> 1356
<211> 3166
<212> DNA
<213> Rattus norvegicus
<308> AJ001929
<400> 1356

tagaattca  cggccgcta  attctaggt  gccacggaa  cctgcggcg  ggagctccg  60
ggaaaactc  gtcaaccat  gacctgcgt  agtttctta  gtgcctgtc  ctgtgcacg  120
cctttgctt  gagcaagcc  acagaaaag  aggaccgag  acaccatga  cctcagctc  180
gcgacaaag  tcacaacga  gctcagaat  tcgactatg  ccatgatgc  ttcttggga  240
cagaagagg  aaagagttt  ggtcagctg  caccagaag  gagcaagga  aagcttgga  300
tgattgtag  taaaataga  accgataaa  atgggtttg  gaccgaggg  gagctgaag  360
gccggatca  gcacgccca  aagaaatac  tatatgaca  tgttgaaaa  cagtggcag  420
agtttgata  gaatcaaga  ggcttaatc  cctgggatg  gtacagaaa  gtgacttat  480
gcacttacc  ggatgatcc  gaccctgat  atggattta  ttataaacc  attatggtt  540
gagatgagc  gaggttcaa  atggccgac  aagatggag  ccttattgc  acaaaggag  600
agtttaccg  ttttctgca  cctgaggaa  atgactaca  gaaagacat  gtcctgcag  660
aaaccatgg  ggatataga  cagaatgct  atggtttta  tgatctaga  gagtatatt  720
gtgacatgt  cagtcatga  gggaatgct  atgaacccc  gtgggttaa  acagagcgg  780
agcagttcg  tgagtttcg  gataagaac  gggatggaa  gatggacaa  gaagagacc  840
aagactgga  cctcccttc  gactatgac  atgcagagg  cgaagccag  catctcgtc  900
atgagtccg  ccaagacaa  gatggcaag  tcaccaagg  ggagattgt  gacaagtat  960
atttatttg  gggcagcca  gccacagat  tcggggagg  cttagtacg  cacgatgag  1020
tctaagctg  aaacagagg  gccttcatt  cttcaaaag  aatttattt  tacaggtct  1080
gtttcacat  aaattgttt  cgctactga  actgttatt  caaactttt  aagacgtga  1140
aaggcatat  gagatagtg  aatcacccg  ccccattcc  cctccctct  aggggctgg  1200
aggaaccca  gcttctgag  aacaactct  attagtaca  ttgtgtctg  aggtttaca  1260
tttgtataa  gtataacat  gtgtgttta  ttttgtatt  ttctctagt  gggagtata  1320
tatgaagga  ggagatcct  aacccacac  tgtaggcat  cattagcca  ttacacttt  1380
tcaatccct  accacattt  ttttttaat  attctcact  aactaattt  ttaaagcct  1440
agatcaata  gaaatgttc  ggagagaaa  agcagaagg  aagcatgta  ttcgtgatt  1500
acgttcaga  agagaatgc  tcatcttgc  tgttgagaa  tctcatttc  tgagtagct  1560
ttcagttgt  acaggccca  ccacggagc  tgccattgt  tgggcaagg  cagagtcct  1620
cgctgtaag  cagcgtcac  cagctccac  tcactcttc  cctcaggac  agctgtttg  1680
taattttgt  aagcacagc  gtggtagga  gaattaggg  ccagtgtct  gaaaaatca  1740
ccaagtagt  tgtatgatg  cttcacagg  ctatttcta  ctctttcta  agctgtttc  1800
aaccagaaa  agctggaaa  caaaaagaa  aaagtgtat  cagggcatg  atctcattc  1860
tagtgaaat  actacaagg  cccatccca  cccctttct  agtcttaac  ttgggtttt  1920
ctgcagttt  aattgattc  tttcccatc  tgacattga  agttgccct  taacaggaa  1980
aatggtcac  gaatgagaa  tgggactca  gaataacga  tttggggcg  ccttacgtt  2040
aaagcattt  aacctccct  ataccgaag  ggattcccc  ccccgcctt  ttctcttgt  2100
aacaggaag  aaatagcat  attagttaa  gcttggttg  agtgttctt  tcttgtggg  2160
tggtttcta  aacctcatg  tgctgattt  accagggca  cctcatacc  cagatgcaa  2220
ccactcttc  accgggcct  tgtttaccg  agctttgcc  caaggatag  aggctgtac  2280
gaggggctc  ttggtttga  gaccactgc  cacccttcc  gtcattaac  tgtcacacc  2340
cattttatc  tctcccttt  tctctgaca  acaaaggtg  ggtacgtgg  agggtcgtg  2400
attattctt  ttaaaaaac  aaatcatct  ttgccaacc  catttaccc  tctttggtc  2460
cttactgat  ggcctctta  gaattattg  attccaagt  tttaaccct  atgttacta  2520
tgtaaatat  catctgggc  gtctttatt  cttcctgta  ctctgagta  tacatcaag  2580
tggtgctgg  tgatggtca  atctgaacc  agacctccc  gtgggtctt  cacaatcct  2640
ttgatgtgg  ctgcttggt  tggtaaaaa  cccagtcgt  gtgtaactt  accttggcg  2700
ttgcatcaa  cttcttgat  gcagataca  tctaaggtt  tagccccag  agaggtgaa  2760
tgaacatcc  tcactgcct  ccccagatc  tcaactctc  attgttaag  agaccagag  2820
taattaatg  caccaaccc  ggcttagaa  gggtacgtc  tacactgtg  agcaagagg  2880
cattacaga  cctaacgct  gcgtgaaaa  catgtactt  gccagcaag  gagtctgcg  2940
gggtggcgt  gtctggaca  ggtgttcag  atcgggaac  gtgctctca  gtccataag  3000
tccacatag  gttggggtt  gggtttggg  ttctggttg  atttgagta  ttgttcttt  3060
tttatagag  gtaaaccaa  ttttatatt  tgtaatgca  acaggtacc  gtcgttttt  3120
gaataaaac  gtttacatc  aaaaaaaaa  aaaaaaaaa  aaaaaa  3166



<210> 1357
<211> 315
<212> PRT
<213> Rattus norvegicus
<308> CAA05100
<400> 1357

Met Asp Leu Arg Gln Phe Leu Met Cys Leu Ser Leu Cys Thr Ala Phe 
  1               5                  10                  15
Ala Leu Ser Lys Pro Thr Glu Lys Lys Asp Arg Val His His Glu Pro 
             20                  25                  30
Gln Leu Ser Asp Lys Val His Asn Asp Ala Gln Asn Phe Asp Tyr Asp 
         35                  40                  45
His Asp Ala Phe Leu Gly Ala Glu Glu Ala Lys Ser Phe Gly Gln Leu 
     50                  55                  60
Thr Pro Glu Glu Ser Lys Glu Lys Leu Gly Met Ile Val Asp Lys Ile 
 65                  70                  75                  80
Asp Thr Asp Lys Asp Gly Phe Val Thr Glu Gly Glu Leu Lys Ser Arg 
                 85                  90                  95
Ile Lys His Ala Gln Lys Lys Tyr Ile Tyr Asp Asn Val Glu Asn Gln 
             100                105                110
Trp Gln Glu Phe Asp Met Asn Gln Asp Gly Leu Ile Ser Trp Asp Glu 
         115                120                125
Tyr Arg Asn Val Thr Tyr Gly Thr Tyr Leu Asp Asp Pro Asp Pro Asp 
     130                135                140
Asp Gly Phe Asn Tyr Lys Pro Ile Met Val Arg Asp Glu Arg Arg Phe 
 145                150                155                160
Lys Met Ala Asp Gln Asp Gly Asp Leu Ile Ala Thr Lys Glu Glu Phe 
                 165                170                175
Thr Ala Phe Leu His Pro Glu Glu Tyr Asp Tyr Met Lys Asp Ile Val 
             180                185                190
Leu Gln Glu Thr Met Glu Asp Ile Asp Gln Asn Ala Asp Gly Phe Ile 
         195                200                205
Asp Leu Glu Glu Tyr Ile Gly Asp Met Tyr Ser His Asp Gly Asn Ala 
     210                215                220
Asp Glu Pro Gln Trp Val Lys Thr Glu Arg Glu Gln Phe Val Glu Phe 
 225                230                235                240
Arg Asp Lys Asn Arg Asp Gly Lys Met Asp Lys Glu Glu Thr Lys Asp 
                 245                250                255
Trp Ile Leu Pro Ser Asp Tyr Asp His Ala Glu Ala Glu Ala Arg His 
             260                265                270
Leu Val Tyr Glu Ser Asp Gln Asp Lys Asp Gly Lys Leu Thr Lys Glu 
         275                280                285
Glu Ile Val Asp Lys Tyr Asp Leu Phe Val Gly Ser Gln Ala Thr Asp 
     290                295                300
Phe Gly Glu Ala Leu Val Arg His Asp Glu Phe 
 305                310                315



<210> 1358
<211> 891
<212> DNA
<213> Homo sapiens
<308> AF257659
<400> 1358

aagcctaca  aaaagaagg  ccgtgtaca  catgagcct  agctcagtg  caaggttca  60
aatgatgct  agagttttg  ttatgacca  gatgccttc  tgggtgctg  agaagcaaa  120
acctttgat  agctgacac  agaagagag  aaggaaagg  ttggaatga  tgtagataa  180
atagacgcg  ataaagatg  gtttgtgac  gagggggag  tgaaatcct  gattaagca  240
gcccagaag  aatacatat  tgacgatgt  gaaaaccaa  ggcaggagt  tgatatgaa  300
caagacggc  taatctcct  ggatgagta  agaaacgtg  cttatggca  ttacctgga  360
gatccagat  ctgatgatg  atttaacta  aaacagatg  tggttagag  tgagcggag  420
tttaaaatg  cagacaagg  tggagacct  attgccacc  aggaggagt  cacagcttt  480
ctgcaccct  aggagtatg  ctacatgaa  gatatagta  tacaggaaa  aatggaaga  540
atagataag  atgctgatg  tttcattga  ctagaagag  atattggtg  catgtacag  600
catgatggg  atactgatg  gccagaatg  gtaaagaca  agcgagagc  gtttgttga  660
tttcgggat  agaaccgtg  tgggaagat  gacaaggaa  agaccaaag  ctggatcct  720
ccctcagac  atgatcatg  agaggcaga  gccaggcac  tggtctatg  atcagacca  780
aacaaggat  gcaagctta  caaggagga  atcgttgac  agtatgact  atttgttgg  840
agccaggcc  cagattttg  ggaggcctt  gtacgacac  atgagttct  a  891



<210> 1359
<211> 315
<212> PRT
<213> Homo sapiens
<308> O43852
<400> 1359

Met Asp Leu Arg Gln Phe Leu Met Cys Leu Ser Leu Cys Thr Ala Phe 
  1               5                  10                  15
Ala Leu Ser Lys Pro Thr Glu Lys Lys Asp Arg Val His His Glu Pro 
             20                  25                  30
Gln Leu Ser Asp Lys Val His Asn Asp Ala Gln Ser Phe Asp Tyr Asp 
         35                  40                  45
His Asp Ala Phe Leu Gly Ala Glu Glu Ala Lys Thr Phe Asp Gln Leu 
     50                  55                  60
Thr Pro Glu Glu Ser Lys Glu Arg Leu Gly Lys Ile Val Ser Lys Ile 
 65                  70                  75                  80
Asp Gly Asp Lys Asp Gly Phe Val Thr Val Asp Glu Leu Lys Asp Trp 
                 85                  90                  95
Ile Lys Phe Ala Gln Lys Arg Trp Ile Tyr Glu Asp Val Glu Arg Gln 
             100                105                110
Trp Lys Gly His Asp Leu Asn Glu Asp Gly Leu Val Ser Trp Glu Glu 
         115                120                125
Tyr Lys Asn Ala Thr Tyr Gly Tyr Val Leu Asp Asp Pro Asp Pro Asp 
     130                135                140
Asp Gly Phe Asn Tyr Lys Gln Met Met Val Arg Asp Glu Arg Arg Phe 
 145                150                155                160
Lys Met Ala Asp Lys Asp Gly Asp Leu Ile Ala Thr Lys Glu Glu Phe 
                 165                170                175
Thr Ala Phe Leu His Pro Glu Glu Tyr Asp Tyr Met Lys Asp Ile Val 
             180                185                190
Val Gln Glu Thr Met Glu Asp Ile Asp Lys Asn Ala Asp Gly Phe Ile 
         195                200                205
Asp Leu Glu Glu Tyr Ile Gly Asp Met Tyr Ser His Asp Gly Asn Thr 
     210                215                220
Asp Glu Pro Glu Trp Val Lys Thr Glu Arg Glu Gln Phe Val Glu Phe 
 225                230                235                240
Arg Asp Lys Asn Arg Asp Gly Lys Met Asp Lys Glu Glu Thr Lys Asp 
                 245                250                255
Trp Ile Leu Pro Ser Asp Tyr Asp His Ala Glu Ala Glu Ala Arg His 
             260                265                270
Leu Val Tyr Glu Ser Asp Gln Asn Lys Asp Gly Lys Leu Thr Lys Glu 
         275                280                285
Glu Ile Val Asp Lys Tyr Asp Leu Phe Val Gly Ser Gln Ala Thr Asp 
     290                295                300
Phe Gly Glu Ala Leu Val Arg His Asp Glu Phe 
 305                310                315



<210> 1360
<211> 2036
<212> DNA
<213> Rattus norvegicus
<308> AJ004858
<400> 1360

gactttttt  cagaagaag  gcgcgcgcc  gggagtgct  tggggtccc  gcgcttgcg  60
cggctgcca  gagttggag  gcgagaaat  aaagcgatt  agagagaga  cgcgcgcgg  120
tccgggccc  ccgccgctt  ttttccggt  gccgcagcc  ccgccgcag  agggaacgg  180
accgggggg  aggggggca  ccgcggacc  gcggggcca  ggactttgc  acttgccgg  240
gaaggtgga  gggcgggag  gggaggggc  cccgcgcag  agaccgagc  cccagcccc  300
ccgcggacc  tggtgcagc  ggccgagag  tcggaagcc  agagcaacc  gccccggga  360
gcgctggac  ccgaggagg  cgagttcat  gcgtgcagc  cggtggccc  ggatgagag  420
gacccggac  ggtgcaaga  ggcgtcggg  cacatcaaa  ggcccatga  cgccttcat  480
gtgtggtcc  agatcgagc  caggaagat  atggagcag  cgcccgaca  gcataacgc  540
gagatctcc  agaggctgg  caagcgttg  aagatgctg  aggacagcg  gaagatccc  600
ttcatccgg  aggcggagc  cctgcgcct  aagcacatg  ctgattatc  cgactacaa  660
taccggccg  gcaaaaagc  caagacgga  ccagccgcc  agcccagcg  gggccagag  720
ccggacaag  gcgcggcgg  cgctaaggc  gccaagggc  cgggcaaga  gtgcgccaa  780
ctcaaggcg  ctgcgggca  ggcgggcgc  ggcaaggcg  cgcagcctg  ggactgcgg  840
gcgggcaag  cagccaagt  cgtcttcct  gacgacgat  atgaagagg  cgacgagga  900
gacgagctg  agctacggc  caagccgga  gcagacgac  acgacgacg  gcccgcgca  960
tcgcacctg  tgccgccac  ggcgcagca  cagccccct  agctgctga  gcgctacag  1020
gtggccaag  tgcccgcca  ccccacgct  agcagtgcc  ccgagtccc  cgagggcgc  1080
agcctttac  acgaagtgc  cgcgggcgg  cggctctac  acagcttca  gaacatcac  1140
aagcagcag  ctccgcccg  gcctcccgc  ctgtcgccc  cgtcctcgc  ctgcgtgtc  1200
acctcctca  ccagcggca  cagcagcgg  agcggcgcc  aggatgccg  cgacctcat  1260
ttcgacctg  gcttgaatt  ctcccaggg  gcgcacagc  cctgcgagc  gccactggg  1320
gcgggagcg  cggggaacc  gtccctgtc  ctggtggat  aggacctgg  ttccttcag  1380
gagggcagc  tgggctccc  cttcgagtt  cccgactac  gcacgccgg  gctgagcga  1440
atgatcgcg  gggactggc  ggaggcgaa  ttctccgac  tggtgttca  gtattgagg  1500
gcacagggc  cctcgggag  cagtcgtgg  ggtcaggat  aagaggatg  tggggggag  1560
gggagaaga  gctcatggt  agagatgtg  cgcagagaa  ttggaaacg  tgatgaaat  1620
ttggagtta  agtgaaatg  gtagtttta  acagatttt  caggttttt  tttttaatc  1680
tttaatttt  aaaaaaatt  tttggtctc  ccactcttc  cttccttta  cgtgtctca  1740
ggtagttgc  cacctagtc  ggattgtga  ttcccccac  cgtaaaaaa  tcgtgtttt  1800
taatttcta  ttctttttc  tgaaattcg  gattgcaac  aaggcggag  ggaccgggc  1860
ggggagggg  ggaggcccc  ctccggaag  cgctgtttg  agctcgtgg  tctttgaag  1920
ctgaaagac  tcggcagag  accctttag  cggcacaac  gttactcta  ggagttgat  1980
ttttttttt  ttaagagat  taaaaagga  ctggtgatt  aaaaaaaaa  aaaaaa  2036



<210> 1361
<211> 396
<212> PRT
<213> Rattus norvegicus
<308> AJ004858
<400> 1361

Met Val Gln Gln Ala Glu Ser Ser Glu Ala Glu Ser Asn Leu Pro Arg 
  1               5                  10                  15
Asp Ala Leu Asp Thr Glu Glu Gly Glu Phe Met Ala Cys Ser Pro Val 
             20                  25                  30
Ala Leu Asp Glu Ser Asp Pro Asp Trp Cys Lys Thr Ala Ser Gly His 
         35                  40                  45
Ile Lys Arg Pro Met Asn Ala Phe Met Val Trp Ser Lys Ile Glu Arg 
     50                  55                  60
Arg Lys Ile Met Glu Gln Ser Pro Asp Met His Asn Ala Glu Ile Ser 
 65                  70                  75                  80
Lys Arg Leu Gly Lys Arg Trp Lys Met Leu Lys Asp Ser Glu Lys Ile 
                 85                  90                  95
Pro Phe Ile Arg Glu Ala Glu Arg Leu Arg Leu Lys His Met Ala Asp 
             100                105                110
Tyr Pro Asp Tyr Lys Tyr Arg Pro Arg Lys Lys Pro Lys Thr Asp Pro 
         115                120                125
Ala Ala Lys Pro Ser Ala Gly Gln Ser Pro Asp Lys Ser Ala Ala Gly 
     130                135                140
Ala Lys Ala Ala Lys Gly Pro Gly Lys Lys Cys Ala Lys Leu Lys Ala 
 145                150                155                160
Pro Ala Gly Lys Ala Gly Ala Gly Lys Ala Ala Gln Pro Gly Asp Cys 
                 165                170                175
Gly Ala Gly Lys Ala Ala Lys Cys Val Phe Leu Asp Asp Asp Asp Glu 
             180                185                190
Glu Asp Asp Glu Asp Asp Glu Leu Gln Leu Arg Pro Lys Pro Asp Ala 
         195                200                205
Asp Asp Asp Asp Asp Glu Pro Ala His Ser His Leu Leu Pro Pro Pro 
     210                215                220
Ala Gln Gln Gln Pro Pro Gln Leu Leu Arg Arg Tyr Ser Val Ala Lys 
 225                230                235                240
Val Pro Ala Ser Pro Thr Leu Ser Ser Ala Ala Glu Ser Pro Glu Gly 
                 245                250                255
Ala Ser Leu Tyr Asp Glu Val Arg Ala Gly Gly Arg Leu Tyr Tyr Ser 
             260                265                270
Phe Lys Asn Ile Thr Lys Gln Gln Pro Pro Pro Ala Pro Pro Ala Leu 
         275                280                285
Ser Pro Ala Ser Ser Arg Cys Val Ser Thr Ser Ser Ser Ser Gly Ser 
     290                295                300
Ser Ser Gly Ser Gly Ala Glu Asp Ala Asp Asp Leu Met Phe Asp Leu 
 305                310                315                320
Ser Leu Asn Phe Ser Gln Gly Ala His Ser Ala Cys Glu Gln Pro Leu 
                 325                330                335
Gly Ala Gly Ala Ala Gly Asn Leu Ser Leu Ser Leu Val Asp Lys Asp 
             340                345                350
Leu Asp Ser Phe Ser Glu Gly Ser Leu Gly Ser His Phe Glu Phe Pro 
         355                360                365
Asp Tyr Cys Thr Pro Glu Leu Ser Glu Met Ile Ala Gly Asp Trp Leu 
     370                375                380
Glu Ala Asn Phe Ser Asp Leu Val Phe Thr Tyr Ter 
 385                390                395



<210> 1362
<211> 177
<212> DNA
<213> Homo sapiens
<308> X73039
<400> 1362

atggtgtgg  gctccgctc  gcgccgcca  atggcgcac  agaacccca  gatgcacaa  60
tccgagatc  ccaagcgcc  gggcgcgca  tggaagctg  tggacgagg  cgagaagcg  120
cccttcgtg  aggaggcca  gcggctccg  gcccgacac  tgcgcgact  tccagac  177



<210> 1363
<211> 441
<212> PRT
<213> Homo sapiens
<308> S34118
<400> 1363

Met Val Gln Gln Ala Glu Ser Leu Glu Ala Glu Ser Asn Leu Pro Arg 
  1               5                  10                  15
Glu Ala Leu Asp Thr Glu Glu Gly Glu Phe Met Ala Cys Ser Pro Val 
             20                  25                  30
Ala Leu Asp Glu Ser Asp Pro Asp Trp Cys Lys Thr Ala Ser Gly His 
         35                  40                  45
Ile Lys Arg Pro Met Asn Ala Phe Met Val Trp Ser Lys Ile Glu Arg 
     50                  55                  60
Arg Lys Ile Met Glu Gln Ser Pro Asp Met His Asn Ala Glu Ile Ser 
 65                  70                  75                  80
Lys Arg Leu Gly Lys Arg Trp Lys Met Leu Lys Asp Ser Glu Lys Ile 
                 85                  90                  95
Pro Phe Ile Arg Glu Ala Glu Arg Leu Arg Leu Lys His Met Ala Asp 
             100                105                110
Tyr Pro Asp Tyr Lys Tyr Arg Pro Arg Lys Lys Pro Lys Met Asp Pro 
         115                120                125
Ser Ala Lys Pro Ser Ala Ser Gln Ser Pro Glu Lys Ser Ala Ala Gly 
     130                135                140
Gly Gly Gly Gly Ser Ala Gly Gly Gly Ala Gly Gly Ala Lys Thr Ser 
 145                150                155                160
Lys Gly Ser Ser Lys Lys Cys Gly Lys Leu Lys Ala Pro Ala Ala Ala 
                 165                170                175
Gly Ala Lys Ala Gly Ala Gly Lys Ala Ala Gln Ser Gly Asp Tyr Gly 
             180                185                190
Gly Ala Gly Asp Asp Tyr Val Leu Gly Ser Leu Arg Val Ser Gly Ser 
         195                200                205
Gly Gly Gly Gly Ala Gly Lys Thr Val Lys Cys Val Phe Leu Asp Glu 
     210                215                220
Asp Asp Asp Asp Asp Asp Asp Asp Asp Glu Leu Gln Leu Gln Ile Lys 
 225                230                235                240
Gln Glu Pro Asp Glu Glu Asp Glu Glu Pro Pro His Gln Gln Leu Leu 
                 245                250                255
Gln Pro Pro Gly Gln Gln Pro Ser Gln Leu Leu Arg Arg Tyr Asn Val 
             260                265                270
Ala Lys Val Pro Ala Ser Pro Thr Leu Ser Ser Ser Ala Glu Ser Pro 
         275                280                285
Glu Gly Ala Ser Leu Tyr Asp Glu Val Arg Ala Gly Ala Thr Ser Gly 
     290                295                300
Ala Gly Gly Gly Ser Arg Leu Tyr Tyr Ser Phe Lys Asn Ile Thr Lys 
 305                310                315                320
Gln His Pro Pro Pro Leu Ala Gln Pro Ala Leu Ser Pro Ala Ser Ser 
                 325                330                335
Arg Ser Val Ser Thr Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Gly 
             340                345                350
Ser Ser Gly Glu Asp Ala Asp Asp Leu Met Phe Asp Leu Ser Leu Asn 
         355                360                365
Phe Ser Gln Ser Ala His Ser Ala Ser Glu Gln Gln Leu Gly Gly Gly 
     370                375                380
Ala Ala Ala Gly Asn Leu Ser Leu Ser Leu Val Asp Lys Asp Leu Asp 
 385                390                395                400
Ser Phe Ser Glu Gly Ser Leu Gly Ser His Phe Glu Phe Pro Asp Tyr 
                 405                410                415
Cys Thr Pro Glu Leu Ser Glu Met Ile Ala Gly Asp Trp Leu Glu Ala 
             420                425                430
Asn Phe Ser Asp Leu Val Phe Thr Tyr 
         435                440



<210> 1364
<211> 1314
<212> DNA
<213> Rattus norvegicus
<308> AJ004912
<400> 1364

atgtctggt  tgtctggcc  actatcctg  cctggccct  tcctatccg  cttgctctt  60
ctgttcctt  tcggcccca  ctcggtcct  ggcatctcc  tccatctac  cgtgaactc  120
cgcaagtgt  tccgcgagg  gatccacaa  gacttgctg  ttacgggcg  gtacgagat  180
accgaccag  ctgggggcg  tggcggcct  cgcacccac  tcaagatca  agattctgc  240
ggccatatt  tgtatgcca  agaggatgc  actaaaggg  agtttgcct  taccacaga  300
gactatgac  tgtttgaag  atgctttga  agcaaggga  cagggcgga  acctgacca  360
ctagtgatt  tagacatga  gcatggagt  gaggcgaaa  attatgaag  gatcgcaaa  420
gttgagaaa  tcaaaccac  ggaggtgga  ctacggcgc  tcgaggacc  ttcagagtc  480
attgttaac  actttgcct  catgaagaa  cgggaagag  agatgaggg  caccaacga  540
tccacaaac  cccgcgtcc  gtacttcag  atcttttcc  tgttctgcc  cattggact  600
gccacctgg  aggtcttct  cctgcgtcg  ttcttcaag  ccaagaagt  gatagagta  660
tgaggctca  tcttctgtc  cctggagcc  gcagaacat  gctgggacg  gcctggcct  720
gcccaaggc  aagttacta  cagtatatc  aggcgcacg  gagcatctt  ccagaactg  780
tccttctgg  gtgggagag  atgggcacc  cccacaccc  gcaagtcag  gaggacttt  840
taatgcagt  ggatttgga  tggtttgca  caagattat  aaagtcgcc  atggaaaaa  900
aaaacaaaa  aaaacaaca  acaggggtt  cctagataa  gccaaagcc  gcattcgtc  960
tgggtcgcc  cacaggatc  gtttgagct  tttgctttt  ctctcccac  tgctcaccg  1020
cttggtcct  cactctagt  ctcctccaa  atttctctg  cctcggtca  ctccttcat  1080
tcagttgtc  ctttggttt  cttgtgaaa  accttgaac  tctcttggt  cttagatga  1140
atgtttaca  agcttctgg  gatatcctt  ataatttta  gtcttctaa  agggtcatg  1200
gtgggacac  aaacaaagt  agctttgaa  tgtagataa  ctcttaaaa  aaaatctca  1260
tttagacca  taaaatgtt  gtgctcaaa  aaaaaaaaa  aaaaaaaaa  aaaa  1314



<210> 1365
<211> 203
<212> PRT
<213> Rattus norvegicus
<308> Q63584
<400> 1365

Ala Leu Leu Phe Leu Phe Leu Leu Gly Pro Ser Ser Val Leu Gly Ile 
  1               5                  10                  15
Ser Phe His Leu Pro Val Asn Ser Arg Lys Cys Leu Arg Glu Glu Ile 
             20                  25                  30
His Lys Asp Leu Leu Val Thr Gly Ala Tyr Glu Ile Thr Asp Gln Ser 
         35                  40                  45
Gly Gly Ala Gly Gly Leu Arg Thr His Leu Lys Ile Thr Asp Ser Ala 
     50                  55                  60
Gly His Ile Leu Tyr Ala Lys Glu Asp Ala Thr Lys Gly Lys Phe Ala 
 65                  70                  75                  80
Phe Thr Thr Glu Asp Tyr Asp Met Phe Glu Val Cys Phe Glu Ser Lys 
                 85                  90                  95
Gly Thr Gly Arg Ile Pro Asp Gln Leu Val Ile Leu Asp Met Lys His 
             100                105                110
Gly Val Glu Ala Lys Asn Tyr Glu Glu Ile Ala Lys Val Glu Lys Leu 
         115                120                125
Lys Pro Leu Glu Val Glu Leu Arg Arg Leu Glu Asp Leu Ser Glu Ser 
     130                135                140
Ile Val Asn Asp Phe Ala Tyr Met Lys Lys Arg Glu Glu Glu Met Arg 
 145                150                155                160
Asp Thr Asn Glu Ser Thr Asn Thr Arg Val Leu Tyr Phe Ser Ile Phe 
                 165                170                175
Ser Met Phe Cys Leu Ile Gly Leu Ala Thr Trp Gln Val Phe Tyr Leu 
             180                185                190
Arg Arg Phe Phe Lys Ala Lys Lys Leu Ile Glu 
         195                200



<210> 1366
<211> 690
<212> DNA
<213> Homo sapiens
<308> X97442
<400> 1366

tctccagca  catgtctgg  ttgtctggc  caccagccc  gcgcggccc  tttccgtta  60
cgttgctgc  tttgttcct  ctcggcccc  gattggtcc  tgccatctc  ttccatctg  120
ccattaact  tcgcaagtg  ctccgtgag  agattcaca  ggacctgct  gtgactggc  180
cgtacgaga  ctccgacca  tctgggggc  ctggcggcc  gcgcagcca  ctcaagatc  240
cagattctg  tggccatat  ctctactcc  aagaggatg  aaccaaggg  aaatttgcc  300
ttaccactg  agattatga  atgtttgaa  tgtgttttg  gagcaaggg  acagggcgg  360
tacctgacc  actcgtgat  ctagacatg  agcatggag  ggaggcgaa  aattacgaa  420
agattgcaa  agttgagaa  ctcaaacca  tagaggtag  gctgcgacg  ctagaagac  480
tttcagaat  tattgttaa  gactttgcc  acatgaaga  gagagaaga  gagatgcgt  540
ataccaacg  gtcaacaaa  actcgggtc  tatacttca  catcttttc  atgttctgt  600
tcattggac  agctacctg  caggtcttc  acctgcgac  cttcttcaa  gccaagaaa  660
tgattgagt  atgaatgag  tgcctggcct  690



<210> 1367
<211> 219
<212> PRT
<213> Homo sapiens
<308> P49755
<400> 1367

Met Ser Gly Leu Ser Gly Pro Pro Ala Arg Arg Gly Pro Phe Pro Leu 
  1               5                  10                  15
Ala Leu Leu Leu Leu Phe Leu Leu Gly Pro Arg Leu Val Leu Ala Ile 
             20                  25                  30
Ser Phe His Leu Pro Ile Asn Ser Arg Lys Cys Leu Arg Glu Glu Ile 
         35                  40                  45
His Lys Asp Leu Leu Val Thr Gly Ala Tyr Glu Ile Ser Asp Gln Ser 
     50                  55                  60
Gly Gly Ala Gly Gly Leu Arg Ser His Leu Lys Ile Thr Asp Ser Ala 
 65                  70                  75                  80
Gly His Ile Leu Tyr Ser Lys Glu Asp Ala Thr Lys Gly Lys Phe Ala 
                 85                  90                  95
Phe Thr Thr Glu Asp Tyr Asp Met Phe Glu Val Cys Phe Glu Ser Lys 
             100                105                110
Gly Thr Gly Arg Ile Pro Asp Gln Leu Val Ile Leu Asp Met Lys His 
         115                120                125
Gly Val Glu Ala Lys Asn Tyr Glu Glu Ile Ala Lys Val Glu Lys Leu 
     130                135                140
Lys Pro Leu Glu Val Glu Leu Arg Arg Leu Glu Asp Leu Ser Glu Ser 
 145                150                155                160
Ile Val Asn Asp Phe Ala Tyr Met Lys Lys Arg Glu Glu Glu Met Arg 
                 165                170                175
Asp Thr Asn Glu Ser Thr Asn Thr Arg Val Leu Tyr Phe Ser Ile Phe 
             180                185                190
Ser Met Phe Cys Leu Ile Gly Leu Ala Thr Trp Gln Val Phe Tyr Leu 
         195                200                205
Arg Arg Phe Phe Lys Ala Lys Lys Leu Ile Glu 
     210                215



<210> 1368
<211> 1282
<212> DNA
<213> Rattus norvegicus
<308> AJ005046
<400> 1368

ccttgagag  gcaaggatt  ctacgagag  aaggagctt  gaagtttca  ttgccacaa  60
gacggacag  agccccttt  agacagaca  gctgaccct  acccgttac  ttatggaaa  120
ggggcgaca  gccaaaggg  ccggagaac  cacccagct  ctcaactcg  tgctgactg  180
catcaaagc  atctcttcc  ctgtgcgaa  ggccggcct  gccaacctg  atgggattg  240
gggaagcgt  aatgtgaca  gggatgagg  gaagaaact  gatgtgctg  ccaattccc  300
ggtgatcaa  atgcttcag  cctcctaca  cacctgtgt  cttgtctca  aagagaata  360
agaggctgt  atcacagcc  aggagagga  ggggaaata  gtggtttgc  ttgacccac  420
ggatggatc  tcaaacatt  actgcctgg  ttccattgg  actatattt  ctatctaca  480
aaagaccac  gaggatgag  cttccgaga  ggatgcctt  cagcctgga  gcaatatcg  540
ggctgcagg  tatgcactg  atggtagtg  aaccctggt  gctctttct  cagggcaag  600
agtggatct  ttcatgctg  acccggctc  tggagaatt  gtgctagtg  aaaaagata  660
ccggattaa  aagaaaggg  aaattttta  cctcaatga  ggctatgcc  agtattttg  720
tgctgctac  gctgagtat  tacagaaaa  gaagttccc  gaggatggc  gtgcacctt  780
cggggcaag  tacgtgggt  ccatggtgg  tgatgtgca  cgcaccctg  tctatggag  840
aatcttcat  tacccagcc  accagaaga  tcctaatgg  aagctccgg  tcctgtatg  900
atgcaatcc  gtagcctat  tcattgagc  ggcaggagg  atggcaacc  caggcaccc  960
gccggtact  gatgtaaag  ctgagagca  tcaccagcg  gtccccctc  ttctggggt  1020
cccggaaga  gtgcaagaa  atctcagct  tgtgcaaag  aaccaggca  gcaggtagt  1080
atcctgaac  catgagccc  cttcccttt  tctttgaca  atgaaaaac  agatgaatg  1140
agatggggg  aaagacaag  atgccacgc  caacaggtt  ccttcagaa  agcgcttag  1200
tggcaagca  agggttaga  gccagaggt  aagatatga  tgaagggct  aaataaaaa  1260
atgaatgtg  aaaaaaaaa  aa  1282



<210> 1369
<211> 339
<212> PRT
<213> Rattus norvegicus
<308> CAA06313
<400> 1369

Met Thr Asp Arg Ser Pro Phe Glu Thr Asp Met Leu Thr Leu Thr Arg 
  1               5                  10                  15
Tyr Val Met Glu Lys Gly Arg Gln Ala Lys Gly Thr Gly Glu Leu Thr 
             20                  25                  30
Gln Leu Leu Asn Ser Met Leu Thr Ala Ile Lys Ala Ile Ser Ser Ala 
         35                  40                  45
Val Arg Lys Ala Gly Leu Ala Asn Leu Tyr Gly Ile Ala Gly Ser Val 
     50                  55                  60
Asn Val Thr Gly Asp Glu Val Lys Lys Leu Asp Val Leu Ser Asn Ser 
 65                  70                  75                  80
Leu Val Ile Asn Met Leu Gln Ser Ser Tyr Ser Thr Cys Val Leu Val 
                 85                  90                  95
Ser Glu Glu Asn Lys Glu Ala Val Ile Thr Ala Lys Glu Arg Arg Gly 
             100                105                110
Lys Tyr Val Val Cys Phe Asp Pro Leu Asp Gly Ser Ser Asn Ile Asp 
         115                120                125
Cys Leu Ala Ser Ile Gly Thr Ile Phe Ala Ile Tyr Arg Lys Thr Thr 
     130                135                140
Glu Asp Glu Pro Ser Glu Lys Asp Ala Leu Gln Pro Gly Arg Asn Ile 
 145                150                155                160
Val Ala Ala Gly Tyr Ala Leu Tyr Gly Ser Ala Thr Leu Val Ala Leu 
                 165                170                175
Ser Thr Gly Gln Gly Val Asp Leu Phe Met Leu Asp Pro Ala Leu Gly 
             180                185                190
Glu Phe Val Leu Val Glu Lys Asp Ile Arg Ile Lys Lys Lys Gly Lys 
         195                200                205
Ile Phe Ser Leu Asn Glu Gly Tyr Ala Lys Tyr Phe Asp Ala Ala Thr 
     210                215                220
Ala Glu Tyr Val Gln Lys Lys Lys Phe Pro Glu Asp Gly Ser Ala Pro 
 225                230                235                240
Tyr Gly Ala Arg Tyr Val Gly Ser Met Val Ala Asp Val His Arg Thr 
                 245                250                255
Leu Val Tyr Gly Gly Ile Phe Met Tyr Pro Ala Asn Gln Lys Ser Pro 
             260                265                270
Asn Gly Lys Leu Arg Leu Leu Tyr Glu Cys Asn Pro Val Ala Tyr Ile 
         275                280                285
Ile Glu Gln Ala Gly Gly Met Ala Thr Thr Gly Thr Gln Pro Val Leu 
     290                295                300
Asp Val Lys Pro Glu Ser Ile His Gln Arg Val Pro Leu Ile Leu Gly 
 305                310                315                320
Ser Pro Glu Asp Val Gln Glu Tyr Leu Ser Cys Val Gln Arg Asn Gln 
                 325                330                335
Ala Gly Arg 
             340



<210> 1370
<211> 1332
<212> DNA
<213> Homo sapiens
<308> NM_003837
<400> 1370

gctgcagcc  tcagaagta  gcaaggttt  ctgccggga  aaaaggatt  gaagcattc  60
agccaaaat  acggacaga  gccccttcg  aaccgacat  ctcaccctg  cccgctacg  120
tatggaaaa  gggcgtcag  ccaaaggga  tggggagct  acccagctg  tgaactcaa  180
gctgacggc  atcaaagcc  tctcctcgg  tgtgcgcaa  gccggtctg  cccacctgt  240
tggaatcgc  ggaagcgtt  acgtgacgg  agatgaggt  aagaaactg  atgtgctat  300
caattccct  gtgatcaac  tgctccaat  ctcctatag  acctgcgtc  tggtctcag  360
agagaataa  gacgccatc  tcaccgcca  ggagaagcg  gggaaatac  tggtctgct  420
tgacccact  gatggatct  ccaatattg  ctgcctggc  tccatcgga  ccatctttg  480
catctatag  aagacctca  aggatgagc  ttctgaaaa  gatgccctg  agtgtggcc  540
caatattgt  gccgcaggt  atgcgctgt  cggtagtgc  accctggtg  ctctctcca  600
agggcaagg  gtggacctc  tcatgcttg  cccggctct  ggtgaattt  tcctggtgg  660
aaaagatgt  aagattaag  agaaaggaa  gatttacag  ctgaatgag  gctatgcca  720
gtattttga  gcggccacc  ctgaatatg  gcagaaaaa  aaattccct  aggatggca  780
tgctcccta  ggggccagg  atgtgggct  catggtggc  gacgtgcac  gcaccctgg  840
ctatggagg  atcttcctg  acccagcca  ccagaagag  cctaagggc  agctccggc  900
cctgtatga  tgcaatccc  tggcctaca  cattgagca  gcaggaggc  tggcgacca  960
ggggaccca  cctgtactg  acgtgaagc  cgaggcaat  caccagcga  tccccctca  1020
tctggggtc  ccagaggat  tgcaggaat  tctcacctg  gtgcagaaa  atcaggcag  1080
cagctagcg  gtttgaccc  acatgccct  ttctgtttg  tttgcacct  gtctaagga  1140
cctaaatga  cgataaaca  agatggtag  tatgagtat  caaaaggta  atccactta  1200
tcacataca  aagagcaac  acaaactgc  tacgacagg  ttggaagcc  caggcgatt  1260
tatggtcaa  gtgaaggac  agaaataaa  acccacatg  ggaaaaaaa  aaaaaaaaa  1320
aaaaaaaaa  aa  1332



<210> 1371
<211> 339
<212> PRT
<213> Homo sapiens
<308> O00757
<400> 1371

Met Thr Asp Arg Ser Pro Phe Glu Thr Asp Met Leu Thr Leu Thr Arg 
  1               5                  10                  15
Tyr Val Met Glu Lys Gly Arg Gln Ala Lys Gly Thr Gly Glu Leu Thr 
             20                  25                  30
Gln Leu Leu Asn Ser Met Leu Thr Ala Ile Lys Ala Ile Ser Ser Ala 
         35                  40                  45
Val Arg Lys Ala Gly Leu Ala His Leu Tyr Gly Ile Ala Gly Ser Val 
     50                  55                  60
Asn Val Thr Gly Asp Glu Val Lys Lys Leu Asp Val Leu Ser Asn Ser 
 65                  70                  75                  80
Leu Val Ile Asn Met Leu Gln Ser Ser Tyr Ser Thr Cys Val Leu Val 
                 85                  90                  95
Ser Glu Glu Asn Lys Asp Ala Ile Ile Thr Ala Lys Glu Lys Arg Gly 
             100                105                110
Lys Tyr Val Val Cys Phe Asp Pro Leu Asp Gly Ser Ser Asn Ile Asp 
         115                120                125
Cys Leu Ala Ser Ile Gly Thr Ile Phe Ala Ile Tyr Arg Lys Thr Ser 
     130                135                140
Glu Asp Glu Pro Ser Glu Lys Asp Ala Leu Gln Cys Gly Arg Asn Ile 
 145                150                155                160
Val Ala Ala Gly Tyr Ala Leu Tyr Gly Ser Ala Thr Leu Val Ala Leu 
                 165                170                175
Ser Thr Gly Gln Gly Val Asp Leu Phe Met Leu Asp Pro Ala Leu Gly 
             180                185                190
Glu Phe Val Leu Val Glu Lys Asp Val Lys Ile Lys Lys Lys Gly Lys 
         195                200                205
Ile Tyr Ser Leu Asn Glu Gly Tyr Ala Lys Tyr Phe Asp Ala Ala Thr 
     210                215                220
Thr Glu Tyr Val Gln Lys Lys Lys Phe Pro Glu Asp Gly Ser Ala Pro 
 225                230                235                240
Tyr Gly Ala Arg Tyr Val Gly Ser Met Val Ala Asp Val His Arg Thr 
                 245                250                255
Leu Val Tyr Gly Gly Ile Phe Leu Tyr Pro Ala Asn Gln Lys Ser Pro 
             260                265                270
Lys Gly Lys Leu Arg Leu Leu Tyr Glu Cys Asn Pro Val Ala Tyr Ile 
         275                280                285
Ile Glu Gln Ala Gly Gly Leu Ala Thr Thr Gly Thr Gln Pro Val Leu 
     290                295                300
Asp Val Lys Pro Glu Ala Ile His Gln Arg Val Pro Leu Ile Leu Gly 
 305                310                315                320
Ser Pro Glu Asp Val Gln Glu Tyr Leu Thr Cys Val Gln Lys Asn Gln 
                 325                330                335
Ala Gly Ser 
             340



<210> 1372
<211> 3933
<212> DNA
<213> Rattus norvegicus
<308> AJ005113
<400> 1372

gaattcggc  taggagtaa  gcacggcct  ttctacgct  gcccctttg  catgggttt  60
ctgaaactg  ttgagattg  gaactttaa  tcgtacaag  gtcgacaaa  tatcggacc  120
tttcagagg  tcaccgcca  cattggacc  aatggctct  gtaagtcaa  tctcatgga  180
gccatcagc  ttgtgcttg  tgaaaaaac  agcaacctg  gggtaaaga  cctgaggga  240
ctgatacac  gagctcctg  gggcaagcc  gctgccaac  gagcctttg  cagcatggt  300
tactccgag  agggtgctg  ggaccgcac  tttgcccga  tcattgtag  gggctcttc  360
gagtacaag  tcaataaca  agttgtcca  ctacatgaa  acagtgaag  gttagagaa  420
ttgggcatt  tcatcaaag  tcgtaactt  ctcgtcttc  agggtgcag  ggaatctat  480
gccatgaag  accccaagg  gaggacagc  ttatttgaa  aaattagtc  ctctgggga  540
cttgcacag  agtatgaca  gcgaaagaa  gaaatggtg  aggctgaag  agacacaca  600
tttaattat  atcgcaaga  aaatattgc  gctgaacgc  aggaggcca  acaagaaaa  660
gaagaggct  accgctacc  ggccctgaa  gatgaggta  tacgcgcac  ggtacaatt  720
cagcttttt  aactctacc  caacgaagt  gagattgag  agctcaaca  ggaactggc  780
tcgaagaac  aggaaattg  gaaggacaa  aagcggatg  acaaggtag  ggatgaact  840
aaggagaag  agaaagagc  gggcaaaat  atgcgggaa  agcagcaga  tgagaagga  900
atcaaggaa  aggactcag  attgaatca  aagaggcct  agtacatca  agcaaaaga  960
aatacatcc  acaaaatca  gaagcttga  gcagccaag  aatctctgc  gaatcgtca  1020
aaacattat  agaaacgta  aggtgacat  gatgagctg  agaaagaga  gctgtcagt  1080
gagaaggcc  gacaggagt  tgaagagcg  atggaggaa  agagtcaga  tcaaggcag  1140
gacttgacc  tggaggaga  ccaggtaaa  aaataccac  gattaaaag  ggaagctag  1200
aagagagca  ccactttgg  tcaggagct  gagaagttt  atcgagacc  gaaagctga  1260
caggaccgt  tagatctag  agagcggaa  aaagtagag  cagaggcca  gatcaagca  1320
aaactgcgg  agattgaag  gaatcagaa  cggattgag  agctagagg  atatattac  1380
actagcaag  agtctctag  ggaacagaa  aagctagag  gagaattga  agaagaagt  1440
gagatggcc  agcgtcgta  tgatgagat  aataaggag  tgaaccagg  gatggagca  1500
ttgggggat  cgcgcattg  ccggcagga  agcagccgc  agcagagga  ggcagaaat  1560
atggaaagc  tcaagcgtc  ctaccctgg  tctgtgtat  gccgcctca  tgacctctg  1620
cagcctaca  aaaagaagt  tcagattgc  gtgaccaag  ttttaggaa  gaacatgga  1680
gctattatt  tagactccg  gaagacagg  cgggattgt  ttcagtata  caaggagca  1740
cgtggagag  ctgagacct  cttgcctct  gactacctg  aggtgaaac  tactgatga  1800
aaactccga  aactgaagg  ggccaagct  gtgattgat  tgattcgct  tgagccacc  1860
cacatcaaa  aagctctgc  gtatgcttg  ggcaatgcc  ttgtttgtg  caatgtgga  1920
gatgcgcga  gaattgcct  tggaggtca  caacgccac  agacagtgg  attggatgg  1980
accctgttc  agaagtcag  agttatctc  ggtggagcc  gtgatctca  ggcaaaggc  2040
cgacgctgg  atgagaagg  agtagacaa  ctaaaagaa  aaaaagaac  tttgacgga  2100
gagctaaaa  agcagatga  ggcaaaacg  aaagaggca  agctgcgtc  ggtgcagtc  2160
caggcccat  ggctacaaa  gcggctgaa  tactcacag  gtgacctag  acagactaa  2220
acaaggcat  ttgccctga  tctccagga  aaatctaag  tggagagtg  actagccaa  2280
ttcgggcct  gaattaatg  tatcaagag  atcatacag  gccgagaga  ggaaatgaa  2340
gacttgaag  agaagatga  ccaggtgga  gatgaggtg  ttgaagagt  ttgtcggga  2400
attggtgtg  gtaacatcc  cgaatttga  gaagaaaag  tgaagcggc  gaatgaaat  2460
gccaagaaa  gcttggaat  tgagaatca  aagactcgc  tgggcatcc  gttggattt  2520
gaaaagaat  agttgaagg  ggaccagga  aaagtacac  tgtgggagc  gacagtaaa  2580
aaggatgaa  atgagatag  aaagcttaa  aaggaggag  aaagacaca  gaagataat  2640
gatgaaacc  tggctcagc  ccaagacct  aagaatcag  acctggcca  aaagtcaga  2700
gtgaatgac  agaatcatg  gatggaaga  attcgcaag  agcttgggg  tgccaataa  2760
gaaatgact  acttacaga  ggaagtgac  gccattgag  ccaagcttg  acagaagcg  2820
agtgaccgc  acaacctgc  acaggcctg  aagatgcag  acatcaaat  gccactgtc  2880
aagggcacc  tggatgata  tagtcagga  gaaggtggc  cccagggag  agagtcagt  2940
agtggttcc  agagaacat  tagtatcta  gcacgagag  ccctcattg  gattgacta  3000
ggtgacctg  gtgaagatc  gaaggatgc  caggcggaa  aagaaatca  gcaagagat  3060
aacacactc  agcaaaagc  gaatgagca  cagagtgtg  ttcagagga  tgctgcccc  3120
aacatgaag  ccatggaaa  gctggaaag  gtccgagac  agttccagg  gacctcaga  3180
gaatttgag  cagcacgaa  gcgagcaaa  aaagccaag  aggcatttg  acagataaa  3240
aaggagcgc  ttgaccgat  caatgcttg  tttgaatct  tggctacca  tattgatga  3300
atctacaag  ctctgtccc  taacagcag  gcccaggca  tcttgggcc  cgagaatcc  3360
gaagagccc  atttggatg  tatcaacta  aactgtgta  ctcctggca  acgtttccg  3420
cctatggac  atttgtcag  cggggagaa  acagttgcc  cactggcct  gctttttgc  3480
attcacagc  acaagccag  ccccttctt  gtcctggat  agattgatg  tgccttgga  3540
aacaccaac  ttggcaagg  ggcaaatta  atcaaggag  agtcaactt  caacttcca  3600
gccattgtt  tctctctca  ggaggaatt  tacaccaag  ctgagagcc  cattggagt  3660
tatcctgag  aaggagact  tgtgatcag  aaagtcctg  ccttcgacc  caccaagta  3720
ccagatgcc  accctaacc  caatgaaca  tagcaggaa  tctgtcttc  tgtctggat  3780
cctgaactg  ccttctatc  atcttctct  ctggatctc  tcacccact  tcatggatc  3840
cctggcacc  taccccctt  tgtttgtgt  catgtgtga  tgattgtgt  catgttaat  3900
tgtttgcaa  aataaatac  ggagactgg  ttt  3933



<210> 1373
<211> 1233
<212> PRT
<213> Rattus norvegicus
<308> CAA06377
<400> 1373

Met Gly Phe Leu Lys Leu Ile Glu Ile Glu Asn Phe Lys Ser Tyr Lys 
  1               5                  10                  15
Gly Arg Gln Ile Ile Gly Pro Phe Gln Arg Phe Thr Ala Ile Ile Gly 
             20                  25                  30
Pro Asn Gly Ser Gly Lys Ser Asn Leu Met Asp Ala Ile Ser Phe Val 
         35                  40                  45
Leu Gly Glu Lys Thr Ser Asn Leu Arg Val Lys Thr Leu Arg Asp Leu 
     50                  55                  60
Ile His Gly Ala Pro Val Gly Lys Pro Ala Ala Asn Arg Ala Phe Val 
 65                  70                  75                  80
Ser Met Val Tyr Ser Glu Glu Gly Ala Glu Asp Arg Thr Phe Ala Arg 
                 85                  90                  95
Val Ile Val Gly Gly Ser Ser Glu Tyr Lys Ile Asn Asn Lys Val Val 
             100                105                110
Gln Leu His Glu Tyr Ser Glu Glu Leu Glu Lys Leu Gly Ile Leu Ile 
         115                120                125
Lys Ala Arg Asn Phe Leu Val Phe Gln Gly Ala Val Glu Ser Ile Ala 
     130                135                140
Met Lys Asn Pro Lys Glu Arg Thr Ala Leu Phe Glu Glu Ile Ser Arg 
 145                150                155                160
Ser Gly Glu Leu Ala Gln Glu Tyr Asp Lys Arg Lys Lys Glu Met Val 
                 165                170                175
Lys Ala Glu Glu Asp Thr Gln Phe Asn Tyr His Arg Lys Lys Asn Ile 
             180                185                190
Ala Ala Glu Arg Lys Glu Ala Lys Gln Glu Lys Glu Glu Ala Asp Arg 
         195                200                205
Tyr Gln Ala Leu Lys Asp Glu Val Val Arg Ala Gln Val Gln Leu Gln 
     210                215                220
Leu Phe Lys Leu Tyr His Asn Glu Val Glu Ile Glu Lys Leu Asn Lys 
 225                230                235                240
Glu Leu Ala Ser Lys Asn Lys Glu Ile Glu Lys Asp Lys Lys Arg Met 
                 245                250                255
Asp Lys Val Glu Asp Glu Leu Lys Glu Lys Lys Lys Glu Leu Gly Lys 
             260                265                270
Met Met Arg Glu Gln Gln Gln Ile Glu Lys Glu Ile Lys Glu Lys Asp 
         275                280                285
Ser Glu Leu Asn Gln Lys Arg Pro Gln Tyr Ile Lys Ala Lys Glu Asn 
     290                295                300
Thr Ser His Lys Ile Lys Lys Leu Glu Ala Ala Lys Lys Ser Leu Gln 
 305                310                315                320
Asn Arg Gln Lys His Tyr Lys Lys Arg Lys Gly Asp Met Asp Glu Leu 
                 325                330                335
Glu Lys Glu Met Leu Ser Val Glu Lys Ala Arg Gln Glu Phe Glu Glu 
             340                345                350
Arg Met Glu Glu Glu Ser Gln Ser Gln Gly Arg Asp Leu Thr Leu Glu 
         355                360                365
Glu Asn Gln Val Lys Lys Tyr His Arg Leu Lys Glu Glu Ala Ser Lys 
     370                375                380
Arg Ala Ala Thr Leu Ala Gln Glu Leu Glu Lys Phe Asn Arg Asp Gln 
 385                390                395                400
Lys Ala Asp Gln Asp Arg Leu Asp Leu Glu Glu Arg Lys Lys Val Glu 
                 405                410                415
Thr Glu Ala Lys Ile Lys Gln Lys Leu Arg Glu Ile Glu Glu Asn Gln 
             420                425                430
Lys Arg Ile Glu Lys Leu Glu Glu Tyr Ile Thr Thr Ser Lys Gln Ser 
         435                440                445
Leu Glu Glu Gln Lys Lys Leu Glu Gly Glu Leu Thr Glu Glu Val Glu 
     450                455                460
Met Ala Lys Arg Arg Ile Asp Glu Ile Asn Lys Glu Leu Asn Gln Val 
 465                470                475                480
Met Glu Gln Leu Gly Asp Ala Arg Ile Asp Arg Gln Glu Ser Ser Arg 
                 485                490                495
Gln Gln Arg Lys Ala Glu Ile Met Glu Ser Ile Lys Arg Leu Tyr Pro 
             500                505                510
Gly Ser Val Tyr Gly Arg Leu Ile Asp Leu Cys Gln Pro Thr Gln Lys 
         515                520                525
Lys Tyr Gln Ile Ala Val Thr Lys Val Leu Gly Lys Asn Met Asp Ala 
     530                535                540
Ile Ile Val Asp Ser Glu Lys Thr Gly Arg Asp Cys Ile Gln Tyr Ile 
 545                550                555                560
Lys Glu Gln Arg Gly Glu Pro Glu Thr Phe Leu Pro Leu Asp Tyr Leu 
                 565                570                575
Glu Val Lys Pro Thr Asp Glu Lys Leu Arg Glu Leu Lys Gly Ala Lys 
             580                585                590
Leu Val Ile Asp Val Ile Arg Tyr Glu Pro Pro His Ile Lys Lys Ala 
         595                600                605
Leu Gln Tyr Ala Cys Gly Asn Ala Leu Val Cys Asp Asn Val Glu Asp 
     610                615                620
Ala Arg Arg Ile Ala Phe Gly Gly His Gln Arg His Lys Thr Val Ala 
 625                630                635                640
Leu Asp Gly Thr Leu Phe Gln Lys Ser Gly Val Ile Ser Gly Gly Ala 
                 645                650                655
Ser Asp Leu Lys Ala Lys Ala Arg Arg Trp Asp Glu Lys Ala Val Asp 
             660                665                670
Lys Leu Lys Glu Lys Lys Glu Arg Leu Thr Glu Glu Leu Lys Glu Gln 
         675                680                685
Met Lys Ala Lys Arg Lys Glu Ala Glu Leu Arg Gln Val Gln Ser Gln 
     690                695                700
Ala His Gly Leu Gln Met Arg Leu Lys Tyr Ser Gln Ser Asp Leu Glu 
 705                710                715                720
Gln Thr Lys Thr Arg His Leu Ala Leu Asn Leu Gln Glu Lys Ser Lys 
                 725                730                735
Leu Glu Ser Glu Leu Ala Asn Phe Gly Pro Arg Ile Asn Asp Ile Lys 
             740                745                750
Arg Ile Ile Gln Ser Arg Glu Arg Glu Met Lys Asp Leu Lys Glu Lys 
         755                760                765
Met Asn Gln Val Glu Asp Glu Val Phe Glu Glu Phe Cys Arg Glu Ile 
     770                775                780
Gly Val Arg Asn Ile Arg Glu Phe Glu Glu Glu Lys Val Lys Arg Gln 
 785                790                795                800
Asn Glu Ile Ala Lys Lys Arg Leu Glu Phe Glu Asn Gln Lys Thr Arg 
                 805                810                815
Leu Gly Ile Gln Leu Asp Phe Glu Lys Asn Gln Leu Lys Glu Asp Gln 
             820                825                830
Asp Lys Val His Met Trp Glu Gln Thr Val Lys Lys Asp Glu Asn Glu 
         835                840                845
Ile Glu Lys Leu Lys Lys Glu Glu Gln Arg His Met Lys Ile Ile Asp 
     850                855                860
Glu Thr Met Ala Gln Leu Gln Asp Leu Lys Asn Gln His Leu Ala Lys 
 865                870                875                880
Lys Ser Glu Val Asn Asp Lys Asn His Glu Met Glu Glu Ile Arg Lys 
                 885                890                895
Lys Leu Gly Gly Ala Asn Lys Glu Met Thr His Leu Gln Lys Glu Val 
             900                905                910
Thr Ala Ile Glu Thr Lys Leu Glu Gln Lys Arg Ser Asp Arg His Asn 
         915                920                925
Leu Leu Gln Ala Cys Lys Met Gln Asp Ile Lys Leu Pro Leu Ser Lys 
     930                935                940
Gly Thr Met Asp Asp Ile Ser Gln Glu Glu Gly Gly Ser Gln Gly Glu 
 945                950                955                960
Glu Ser Val Ser Gly Ser Gln Arg Thr Ser Ser Ile Tyr Ala Arg Glu 
                 965                970                975
Ala Leu Ile Glu Ile Asp Tyr Gly Asp Leu Cys Glu Asp Leu Lys Asp 
             980                985                990
Ala Gln Ala Glu Glu Glu Ile Lys Gln Glu Met Asn Thr Leu Gln Gln 
         995                1000                1005
Lys Leu Asn Glu Gln Gln Ser Val Leu Gln Arg Ile Ala Ala Pro Asn 
     1010                1015                1020
Met Lys Ala Met Glu Lys Leu Glu Ser Val Arg Asp Lys Phe Gln Glu 
 1025                1030                1035                1040
Thr Ser Asp Glu Phe Glu Ala Ala Arg Lys Arg Ala Lys Lys Ala Lys 
                 1045                1050                1055
Gln Ala Phe Glu Gln Ile Lys Lys Glu Arg Phe Asp Arg Phe Asn Ala 
             1060                1065                1070
Cys Phe Glu Ser Val Ala Thr Asn Ile Asp Glu Ile Tyr Lys Ala Leu 
         1075                1080                1085
Ser Arg Asn Ser Ser Ala Gln Ala Phe Leu Gly Pro Glu Asn Pro Glu 
     1090                1095                1100
Glu Pro Tyr Leu Asp Gly Ile Asn Tyr Asn Cys Val Ala Pro Gly Lys 
 1105                1110                1115                1120
Arg Phe Arg Pro Met Asp Asn Leu Ser Gly Gly Glu Lys Thr Val Ala 
                 1125                1130                1135
Ala Leu Ala Leu Leu Phe Ala Ile His Ser Tyr Lys Pro Ala Pro Phe 
             1140                1145                1150
Phe Val Leu Asp Glu Ile Asp Ala Ala Leu Asp Asn Thr Asn Ile Gly 
         1155                1160                1165
Lys Val Ala Asn Tyr Ile Lys Glu Gln Ser Thr Cys Asn Phe Gln Ala 
     1170                1175                1180
Ile Val Ile Ser Leu Lys Glu Glu Phe Tyr Thr Lys Ala Glu Ser Leu 
 1185                1190                1195                1200
Ile Gly Val Tyr Pro Glu Gln Gly Asp Cys Val Ile Ser Lys Val Leu 
                 1205                1210                1215
Thr Phe Asp Leu Thr Lys Tyr Pro Asp Ala Asn Pro Asn Pro Asn Glu 
             1220                1225                1230
Gln 
         1235



<210> 1374
<211> 5825
<212> DNA
<213> Homo sapiens
<308> D80000
<400> 1374

atggggttc  tgaaactga  tgagattga  aactttaag  cgtacaagg  tcgacagat  60
atcggacca  ttcagaggt  caccgccat  attggaccc  atggctctg  taagtcaaa  120
ctcatggat  ccatcagct  tgtgctagg  gaaaaaacc  gcaacctgc  ggtaaagac  180
ctgcgggac  tgatccatg  agctcctgt  ggcaagcca  ctgccaacc  ggcctttgt  240
agcatggtc  actctgagg  gggtgctga  gaccgtacc  ttgcccgtg  cattgtagg  300
ggttcttct  agtacaaga  caacaacaa  gtggtccaa  tacatgagt  cagtgagga  360
ttagagaag  tgggcattc  catcaaagc  cgtaacttc  tcgttttcc  gggtgctgt  420
gaatctatt  ccatgaaga  ccccaaaga  aggacagct  tatttgaag  gattagtcg  480
tctggggag  tggcgcagg  gtatgacaa  cgaaagaag  aaatggtga  ggctgaaga  540
gacacacag  ttaattacc  tcgcaagaa  aatattgcg  ctgaacgca  ggaagcaaa  600
caggagaaa  aagaggctg  ccggtacca  cgcctgaag  atgaggtag  acgggctca  660
gtacagctg  agctcttta  gctttacca  aatgaagtg  aaattgaga  gctcaacaa  720
gaactggcc  caaagaaca  ggagatcga  aaggacaag  agcgtatgg  caaggtgga  780
gatgaactg  aggagaaga  gaaggagct  ggcaaaatg  tgcgggagc  gcagcagat  840
gagaaggag  tcaaggaga  ggactcaga  ttgaaccag  agcggcctc  gtacatcaa  900
gccaaggag  acacctccc  caaaatcaa  aagctggaa  cagccaaga  gtctctgca  960
aatgctcag  agcactaca  gaagcgtaa  ggtgacatg  atgagctgg  gaaggagat  1020
ctgtcagtg  agaaggctc  gcaggagtt  gaagaacgg  tggaagaag  gagtcagag  1080
cagggcaga  atttgacgt  ggaggagaa  caggtgaag  aataccacc  gttgaaaga  1140
gaagccagc  agagagcag  taccctggc  caggagctg  agaaattca  tcgagacca  1200
aaagctgac  aggaccgtc  ggatctgga  gaacggaag  aagtagaga  agaggccaa  1260
atcaagcaa  agctgcggg  aattgaaga  aatcagaag  ggattgaga  actggagga  1320
tacatcacc  ctagcaagc  gtccctaga  gagcagaag  agctagagg  ggagctgac  1380
gaggaggtg  agatggcca  gcggcgtat  gatgaaatc  ataaggagc  gaaccaggt  1440
atggagcag  taggggatg  ccgcatcga  cgccaggag  gcagccgcc  gcagcgaaa  1500
gcagagata  tggaaagca  caagcgcct  taccctggc  ctgtgtacg  ccgcctcat  1560
gacctatgc  agcccacac  aaagaagta  cagattgct  taaccaagg  tttgggcaa  1620
aacatggat  ccattattg  ggactcgga  aagacaggc  gggactgta  tcagtatat  1680
aaggagcag  gtggggagc  tgagacctt  ttgcctctt  actacctgg  ggtgaagcc  1740
acagatgag  aactccggg  gctgaaggg  gccaagcta  tgattgatg  gattcgcta  1800
gagccacct  atatcaaaa  ggccctgca  tatgcttgt  gcaatgccc  tgtctgtga  1860
aacgtggaa  atgcccgcc  cattgcctt  ggaggccac  agcgccaca  gacagtggc  1920
ctggatgga  ccctattcc  gaagtcagg  gtgatctct  gtggggcca  tgacctgaa  1980
gccaaggca  ggcgctggg  tgagaaagc  gtagacaag  tgaaagaga  gaaggagcg  2040
ttgacagag  agctgaaag  gcagatgaa  gcaaaacgg  aagaggcag  gctgcgtca  2100
gtgcagtct  aggcccatg  actgcagat  cggctcaag  actcccaga  tgacctaga  2160
cagaccaag  cacgacatc  agccctgaa  ctgcaggaa  aatccaagc  ggagagtga  2220
ctagccaac  ttgggcctc  cattaatga  atcaagagg  tcattcaga  ccgagagag  2280
gaaatgaaa  acttgaagg  gaagatgaa  caggtagag  atgaggtgt  tgaagagtt  2340
tgtcgggag  ttggtgtgc  caacatccg  gagtttgag  aagaaaagg  gaaacggca  2400
aatgaaatc  ccaagaagc  tttggagtt  gagaatcag  agactcgct  gggcattca  2460
ttggatttt  aaaagaacc  actgaagga  gaccaagat  aagtacaca  gtgggagca  2520
acagtgaaa  aagatgaaa  tgagataga  aagctcaaa  aggaggaac  aagacacat  2580
aagatcata  atgagacca  ggctcagct  caagacctg  agaatcagc  tctggccaa  2640
aagtcggaa  tgaatgaca  gaatcatga  atggaggag  ttcgtaaga  actcggggg  2700
gccaacaag  aaatgaccc  tttacagaa  gaggtgaca  ccattgaga  caagcttga  2760
cagaagcgc  gtgaccgtc  caacttgct  caggcctgt  agatgcagg  cattaagtt  2820
ccactgtca  aaggcacca  ggatgatat  agtcaggaa  agggtagct  ccaggggga  2880
gactcagtg  gtggttcac  gagaatttc  agtatctat  cacgagagg  cctcattga  2940
attgactac  gtgatctgt  tgaggatct  aaggatgcc  aggctgagg  agagatcaa  3000
caagagatg  acacactgc  gcagaagct  aatgagcag  agagtgtgc  tcagcgtat  3060
gccgccccc  acatgaagg  catggaaaa  ctggaaagt  tccgagaca  gttccagga  3120
acctcagat  agtttgaag  agcccgaaa  cgagcaaag  aggccaagc  ggcattcga  3180
cagatcaag  aggagcgct  tgaccgctt  aatgcttgt  ttgaatctg  ggctaccaa  3240
attgatgag  tctataagg  cctgtcccg  aatagcagt  cccaggcat  cctgggccc  3300
gagaaccct  aagagccct  cttggatgg  atcaactac  actgtgtgg  tcctgggaa  3360
cgcttccgg  ctatggaca  cttgtcagg  ggggagaag  cagtggcag  tctggccct  3420
ctctttgcc  tccacagct  caagccagc  cccttcttc  tcctggatg  gattgatgc  3480
gccttggat  acaccaaca  tggcaaggt  gcaaattac  tcaaggagc  gtcgacttg  3540
aacttccag  ccatcgtca  ctctctcaa  gaggagttc  acaccaagg  cgagagcct  3600
attggagtc  atcctgagc  aggggactg  gtgatcagc  aagtcctga  cttcgacct  3660
accaagtac  cagatgcca  ccccaaccc  aatgagcag  agcagtatt  ttgccctcc  3720
gccctgtct  gatccctaa  ctgtccctc  cccaatctc  ggatatttg  ctcccaacc  3780
tccccctac  tcctggccc  ttttggtgt  gtcatggga  ttaggcact  ctaatcaag  3840
atgaagagg  acagaggtg  tgttaggtc  ggagcaaaa  ttcctgaac  acagggagt  3900
ttctggcct  tgaaaggag  tgctgagct  aacagggcc  tctgttcat  acacacacc  3960
ccttcctcc  cctcatcac  cataatcgt  ggccccttg  gcctcttgc  cactgtgtg  4020
gtgggtatg  atgtgtgta  gtatgtatc  gcatgtgtg  atgtgagta  gtttgcaaa  4080
taataaagg  tattggaga  ctgttttag  aggagccta  gctgaattt  attccaaga  4140
agcttagga  gacagcacc  ctgagctgg  caaaggtac  caggacctc  taggagtct  4200
aggcagtta  ctgaaactg  cttcattca  tcatttgtg  attcattca  ttatgtatt  4260
atcagacac  taccgaaca  cctctattt  tcaggctct  tgcttggaa  acagagttg  4320
atcagacat  atctctacc  tcctagtaa  gagatacag  gggttcatg  atgactata  4380
ttagctgaa  gtcatatgt  ctttgaatt  gagaagtgg  tgatcccct  taggcttcc  4440
ggaggtcac  tttaagcta  accttgaca  attggtagg  tttggtcag  cactaggag  4500
ggagcatga  ctctgggga  agacagtta  gggttctgg  cccactttt  atcacttac  4560
agttgtttg  ccttgggca  gtcatttga  cttctgtgc  tcagtttcc  catctgtaa  4620
atggggcta  caatattac  tacctcata  gatttaatg  tgtcaagct  ctcactgga  4680
gccttatcc  ttcgtggag  ccactaggt  ccgacccct  agaatataa  cctcatgcc  4740
ggacccctg  gagcttctg  tcccagcta  tagggacag  agaagcctc  aaatctgga  4800
ggtgctgaa  gccctgctg  ctgggaaag  ttcagggca  tgatggggt  tacctggta  4860
gcggagggc  tgaggaaac  tgtagcttc  atcatgtct  gtaaccggg  gcctgagcc  4920
caatctggg  tgtgaggaa  taggggaga  gtatcctgg  ccacatccc  gcctaacac  4980
tgtgaggtt  attttagga  ctaacctca  tagctataa  gatcatgca  aggcagcaa  5040
gccgggtgc  atgagctca  cctttactc  ttcacatac  ccatcacac  ttaattcca  5100
tctgtatat  gctttttaa  agttaagtc  attctaatt  cccaaatat  catgaattc  5160
ttctccttt  gagaagtta  attgttaaa  atagtctca  tcagctacc  accactcct  5220
gatccttcc  ttcttagtg  ctgttgttt  ttgtacttc  gtttagact  tgttttaat  5280
cttgtacgt  catatgtga  ctcattgga  atattgtgt  tttaatgca  atgatatat  5340
gaattgttt  gcaatttgt  ttctttgct  aacgatgtt  ttgagatct  tgcatgtta  5400
ttaatgtag  tcaatccat  ttctgtaat  gctgtatag  ttgtcatca  atgattacc  5460
cattttact  acgcatttc  tttgtgatg  acattaaga  tgtttttag  ttttgctat  5520
acaaaatac  acacaggag  atcactatg  ctgtgtgaa  gtatatgta  gaaagttta  5580
ctagggttg  ttcctagaa  tggaattgc  aagtcatag  atatttata  attggtttt  5640
aataatact  ccaaattgc  ctcctgtac  atttactca  tatttttct  gaggttgat  5700
tgaggtcta  cattgttat  ctatatcat  ttcatccca  gtagtgata  ctgtgaaat  5760
acaggtttg  tgtgtgcta  ttatgtatt  ttctaatac  tattaaaag  cataactat  5820
aaaac  5825



<210> 1375
<211> 1233
<212> PRT
<213> Homo sapiens
<308> NP_006297
<400> 1375

Met Gly Phe Leu Lys Leu Ile Glu Ile Glu Asn Phe Lys Ser Tyr Lys 
  1               5                  10                  15
Gly Arg Gln Ile Ile Gly Pro Phe Gln Arg Phe Thr Ala Ile Ile Gly 
             20                  25                  30
Pro Asn Gly Ser Gly Lys Ser Asn Leu Met Asp Ala Ile Ser Phe Val 
         35                  40                  45
Leu Gly Glu Lys Thr Ser Asn Leu Arg Val Lys Thr Leu Arg Asp Leu 
     50                  55                  60
Ile His Gly Ala Pro Val Gly Lys Pro Ala Ala Asn Arg Ala Phe Val 
 65                  70                  75                  80
Ser Met Val Tyr Ser Glu Glu Gly Ala Glu Asp Arg Thr Phe Ala Arg 
                 85                  90                  95
Val Ile Val Gly Gly Ser Ser Glu Tyr Lys Ile Asn Asn Lys Val Val 
             100                105                110
Gln Leu His Glu Tyr Ser Glu Glu Leu Glu Lys Leu Gly Ile Leu Ile 
         115                120                125
Lys Ala Arg Asn Phe Leu Val Phe Gln Gly Ala Val Glu Ser Ile Ala 
     130                135                140
Met Lys Asn Pro Lys Glu Arg Thr Ala Leu Phe Glu Glu Ile Ser Arg 
 145                150                155                160
Ser Gly Asp Val Ala Gln Glu Tyr Asp Lys Arg Lys Lys Glu Met Val 
                 165                170                175
Lys Ala Glu Glu Asp Thr Gln Phe Asn Tyr His Arg Lys Lys Asn Ile 
             180                185                190
Ala Ala Glu Arg Lys Glu Ala Lys Gln Glu Lys Glu Glu Ala Asp Arg 
         195                200                205
Tyr Gln Arg Leu Lys Asp Glu Val Val Arg Ala Gln Val Gln Leu Gln 
     210                215                220
Leu Phe Lys Leu Tyr His Asn Glu Val Glu Ile Glu Lys Leu Asn Lys 
 225                230                235                240
Glu Leu Ala Ser Lys Asn Lys Glu Ile Glu Lys Asp Lys Lys Arg Met 
                 245                250                255
Asp Lys Val Glu Asp Glu Leu Lys Glu Lys Lys Lys Glu Leu Gly Lys 
             260                265                270
Met Met Arg Glu Gln Gln Gln Ile Glu Lys Glu Ile Lys Glu Lys Asp 
         275                280                285
Ser Glu Leu Asn Gln Lys Arg Pro Gln Tyr Ile Lys Ala Lys Glu Asn 
     290                295                300
Thr Ser His Lys Ile Lys Lys Leu Glu Ala Ala Lys Lys Ser Leu Gln 
 305                310                315                320
Asn Ala Gln Lys His Tyr Lys Lys Arg Lys Gly Asp Met Asp Glu Leu 
                 325                330                335
Glu Lys Glu Met Leu Ser Val Glu Lys Ala Arg Gln Glu Phe Glu Glu 
             340                345                350
Arg Met Glu Glu Glu Ser Gln Ser Gln Gly Arg Asp Leu Thr Leu Glu 
         355                360                365
Glu Asn Gln Val Lys Lys Tyr His Arg Leu Lys Glu Glu Ala Ser Lys 
     370                375                380
Arg Ala Ala Thr Leu Ala Gln Glu Leu Glu Lys Phe Asn Arg Asp Gln 
 385                390                395                400
Lys Ala Asp Gln Asp Arg Leu Asp Leu Glu Glu Arg Lys Lys Val Glu 
                 405                410                415
Thr Glu Ala Lys Ile Lys Gln Lys Leu Arg Glu Ile Glu Glu Asn Gln 
             420                425                430
Lys Arg Ile Glu Lys Leu Glu Glu Tyr Ile Thr Thr Ser Lys Gln Ser 
         435                440                445
Leu Glu Glu Gln Lys Lys Leu Glu Gly Glu Leu Thr Glu Glu Val Glu 
     450                455                460
Met Ala Lys Arg Arg Ile Asp Glu Ile Asn Lys Glu Leu Asn Gln Val 
 465                470                475                480
Met Glu Gln Leu Gly Asp Ala Arg Ile Asp Arg Gln Glu Ser Ser Arg 
                 485                490                495
Gln Gln Arg Lys Ala Glu Ile Met Glu Ser Ile Lys Arg Leu Tyr Pro 
             500                505                510
Gly Ser Val Tyr Gly Arg Leu Ile Asp Leu Cys Gln Pro Thr Gln Lys 
         515                520                525
Lys Tyr Gln Ile Ala Val Thr Lys Val Leu Gly Lys Asn Met Asp Ala 
     530                535                540
Ile Ile Val Asp Ser Glu Lys Thr Gly Arg Asp Cys Ile Gln Tyr Ile 
 545                550                555                560
Lys Glu Gln Arg Gly Glu Pro Glu Thr Phe Leu Pro Leu Asp Tyr Leu 
                 565                570                575
Glu Val Lys Pro Thr Asp Glu Lys Leu Arg Glu Leu Lys Gly Ala Lys 
             580                585                590
Leu Val Ile Asp Val Ile Arg Tyr Glu Pro Pro His Ile Lys Lys Ala 
         595                600                605
Leu Gln Tyr Ala Cys Gly Asn Ala Leu Val Cys Asp Asn Val Glu Asp 
     610                615                620
Ala Arg Arg Ile Ala Phe Gly Gly His Gln Arg His Lys Thr Val Ala 
 625                630                635                640
Leu Asp Gly Thr Leu Phe Gln Lys Ser Gly Val Ile Ser Gly Gly Ala 
                 645                650                655
Ser Asp Leu Lys Ala Lys Ala Arg Arg Trp Asp Glu Lys Ala Val Asp 
             660                665                670
Lys Leu Lys Glu Lys Lys Glu Arg Leu Thr Glu Glu Leu Lys Glu Gln 
         675                680                685
Met Lys Ala Lys Arg Lys Glu Ala Glu Leu Arg Gln Val Gln Ser Gln 
     690                695                700
Ala His Gly Leu Gln Met Arg Leu Lys Tyr Ser Gln Ser Asp Leu Glu 
 705                710                715                720
Gln Thr Lys Thr Arg His Leu Ala Leu Asn Leu Gln Glu Lys Ser Lys 
                 725                730                735
Leu Glu Ser Glu Leu Ala Asn Phe Gly Pro Arg Ile Asn Asp Ile Lys 
             740                745                750
Arg Ile Ile Gln Ser Arg Glu Arg Glu Met Lys Asp Leu Lys Glu Lys 
         755                760                765
Met Asn Gln Val Glu Asp Glu Val Phe Glu Glu Phe Cys Arg Glu Ile 
     770                775                780
Gly Val Arg Asn Ile Arg Glu Phe Glu Glu Glu Lys Val Lys Arg Gln 
 785                790                795                800
Asn Glu Ile Ala Lys Lys Arg Leu Glu Phe Glu Asn Gln Lys Thr Arg 
                 805                810                815
Leu Gly Ile Gln Leu Asp Phe Glu Lys Asn Gln Leu Lys Glu Asp Gln 
             820                825                830
Asp Lys Val His Met Trp Glu Gln Thr Val Lys Lys Asp Glu Asn Glu 
         835                840                845
Ile Glu Lys Leu Lys Lys Glu Glu Gln Arg His Met Lys Ile Ile Asp 
     850                855                860
Glu Thr Met Ala Gln Leu Gln Asp Leu Lys Asn Gln His Leu Ala Lys 
 865                870                875                880
Lys Ser Glu Val Asn Asp Lys Asn His Glu Met Glu Glu Ile Arg Lys 
                 885                890                895
Lys Leu Gly Gly Ala Asn Lys Glu Met Thr His Leu Gln Lys Glu Val 
             900                905                910
Thr Ala Ile Glu Thr Lys Leu Glu Gln Lys Arg Ser Asp Arg His Asn 
         915                920                925
Leu Leu Gln Ala Cys Lys Met Gln Asp Ile Lys Leu Pro Leu Ser Lys 
     930                935                940
Gly Thr Met Asp Asp Ile Ser Gln Glu Glu Gly Ser Ser Gln Gly Glu 
 945                950                955                960
Asp Ser Val Ser Gly Ser Gln Arg Ile Ser Ser Ile Tyr Ala Arg Glu 
                 965                970                975
Ala Leu Ile Glu Ile Asp Tyr Gly Asp Leu Cys Glu Asp Leu Lys Asp 
             980                985                990
Ala Gln Ala Glu Glu Glu Ile Lys Gln Glu Met Asn Thr Leu Gln Gln 
         995                1000                1005
Lys Leu Asn Glu Gln Gln Ser Val Leu Gln Arg Ile Ala Ala Pro Asn 
     1010                1015                1020
Met Lys Ala Met Glu Lys Leu Glu Ser Val Arg Asp Lys Phe Gln Glu 
 1025                1030                1035                1040
Thr Ser Asp Glu Phe Glu Ala Ala Arg Lys Arg Ala Lys Lys Ala Lys 
                 1045                1050                1055
Gln Ala Phe Glu Gln Ile Lys Lys Glu Arg Phe Asp Arg Phe Asn Ala 
             1060                1065                1070
Cys Phe Glu Ser Val Ala Thr Asn Ile Asp Glu Ile Tyr Lys Ala Leu 
         1075                1080                1085
Ser Arg Asn Ser Ser Ala Gln Ala Phe Leu Gly Pro Glu Asn Pro Glu 
     1090                1095                1100
Glu Pro Tyr Leu Asp Gly Ile Asn Tyr Asn Cys Val Ala Pro Gly Lys 
 1105                1110                1115                1120
Arg Phe Arg Pro Met Asp Asn Leu Ser Gly Gly Glu Lys Thr Val Ala 
                 1125                1130                1135
Ala Leu Ala Leu Leu Phe Ala Ile His Ser Tyr Lys Pro Ala Pro Phe 
             1140                1145                1150
Phe Val Leu Asp Glu Ile Asp Ala Ala Leu Asp Asn Thr Asn Ile Gly 
         1155                1160                1165
Lys Val Ala Asn Tyr Ile Lys Glu Gln Ser Thr Cys Asn Phe Gln Ala 
     1170                1175                1180
Ile Val Ile Ser Leu Lys Glu Glu Phe Tyr Thr Lys Ala Glu Ser Leu 
 1185                1190                1195                1200
Ile Gly Val Tyr Pro Glu Gln Gly Asp Cys Val Ile Ser Lys Val Leu 
                 1205                1210                1215
Thr Phe Asp Leu Thr Lys Tyr Pro Asp Ala Asn Pro Asn Pro Asn Glu 
             1220                1225                1230
Gln 
         1235



<210> 1376
<211> 3933
<212> DNA
<213> Rattus norvegicus
<308> AJ005113
<400> 1376

gaattcggc  taggagtaa  gcacggcct  ttctacgct  gcccctttg  catgggttt  60
ctgaaactg  ttgagattg  gaactttaa  tcgtacaag  gtcgacaaa  tatcggacc  120
tttcagagg  tcaccgcca  cattggacc  aatggctct  gtaagtcaa  tctcatgga  180
gccatcagc  ttgtgcttg  tgaaaaaac  agcaacctg  gggtaaaga  cctgaggga  240
ctgatacac  gagctcctg  gggcaagcc  gctgccaac  gagcctttg  cagcatggt  300
tactccgag  agggtgctg  ggaccgcac  tttgcccga  tcattgtag  gggctcttc  360
gagtacaag  tcaataaca  agttgtcca  ctacatgaa  acagtgaag  gttagagaa  420
ttgggcatt  tcatcaaag  tcgtaactt  ctcgtcttc  agggtgcag  ggaatctat  480
gccatgaag  accccaagg  gaggacagc  ttatttgaa  aaattagtc  ctctgggga  540
cttgcacag  agtatgaca  gcgaaagaa  gaaatggtg  aggctgaag  agacacaca  600
tttaattat  atcgcaaga  aaatattgc  gctgaacgc  aggaggcca  acaagaaaa  660
gaagaggct  accgctacc  ggccctgaa  gatgaggta  tacgcgcac  ggtacaatt  720
cagcttttt  aactctacc  caacgaagt  gagattgag  agctcaaca  ggaactggc  780
tcgaagaac  aggaaattg  gaaggacaa  aagcggatg  acaaggtag  ggatgaact  840
aaggagaag  agaaagagc  gggcaaaat  atgcgggaa  agcagcaga  tgagaagga  900
atcaaggaa  aggactcag  attgaatca  aagaggcct  agtacatca  agcaaaaga  960
aatacatcc  acaaaatca  gaagcttga  gcagccaag  aatctctgc  gaatcgtca  1020
aaacattat  agaaacgta  aggtgacat  gatgagctg  agaaagaga  gctgtcagt  1080
gagaaggcc  gacaggagt  tgaagagcg  atggaggaa  agagtcaga  tcaaggcag  1140
gacttgacc  tggaggaga  ccaggtaaa  aaataccac  gattaaaag  ggaagctag  1200
aagagagca  ccactttgg  tcaggagct  gagaagttt  atcgagacc  gaaagctga  1260
caggaccgt  tagatctag  agagcggaa  aaagtagag  cagaggcca  gatcaagca  1320
aaactgcgg  agattgaag  gaatcagaa  cggattgag  agctagagg  atatattac  1380
actagcaag  agtctctag  ggaacagaa  aagctagag  gagaattga  agaagaagt  1440
gagatggcc  agcgtcgta  tgatgagat  aataaggag  tgaaccagg  gatggagca  1500
ttgggggat  cgcgcattg  ccggcagga  agcagccgc  agcagagga  ggcagaaat  1560
atggaaagc  tcaagcgtc  ctaccctgg  tctgtgtat  gccgcctca  tgacctctg  1620
cagcctaca  aaaagaagt  tcagattgc  gtgaccaag  ttttaggaa  gaacatgga  1680
gctattatt  tagactccg  gaagacagg  cgggattgt  ttcagtata  caaggagca  1740
cgtggagag  ctgagacct  cttgcctct  gactacctg  aggtgaaac  tactgatga  1800
aaactccga  aactgaagg  ggccaagct  gtgattgat  tgattcgct  tgagccacc  1860
cacatcaaa  aagctctgc  gtatgcttg  ggcaatgcc  ttgtttgtg  caatgtgga  1920
gatgcgcga  gaattgcct  tggaggtca  caacgccac  agacagtgg  attggatgg  1980
accctgttc  agaagtcag  agttatctc  ggtggagcc  gtgatctca  ggcaaaggc  2040
cgacgctgg  atgagaagg  agtagacaa  ctaaaagaa  aaaaagaac  tttgacgga  2100
gagctaaaa  agcagatga  ggcaaaacg  aaagaggca  agctgcgtc  ggtgcagtc  2160
caggcccat  ggctacaaa  gcggctgaa  tactcacag  gtgacctag  acagactaa  2220
acaaggcat  ttgccctga  tctccagga  aaatctaag  tggagagtg  actagccaa  2280
ttcgggcct  gaattaatg  tatcaagag  atcatacag  gccgagaga  ggaaatgaa  2340
gacttgaag  agaagatga  ccaggtgga  gatgaggtg  ttgaagagt  ttgtcggga  2400
attggtgtg  gtaacatcc  cgaatttga  gaagaaaag  tgaagcggc  gaatgaaat  2460
gccaagaaa  gcttggaat  tgagaatca  aagactcgc  tgggcatcc  gttggattt  2520
gaaaagaat  agttgaagg  ggaccagga  aaagtacac  tgtgggagc  gacagtaaa  2580
aaggatgaa  atgagatag  aaagcttaa  aaggaggag  aaagacaca  gaagataat  2640
gatgaaacc  tggctcagc  ccaagacct  aagaatcag  acctggcca  aaagtcaga  2700
gtgaatgac  agaatcatg  gatggaaga  attcgcaag  agcttgggg  tgccaataa  2760
gaaatgact  acttacaga  ggaagtgac  gccattgag  ccaagcttg  acagaagcg  2820
agtgaccgc  acaacctgc  acaggcctg  aagatgcag  acatcaaat  gccactgtc  2880
aagggcacc  tggatgata  tagtcagga  gaaggtggc  cccagggag  agagtcagt  2940
agtggttcc  agagaacat  tagtatcta  gcacgagag  ccctcattg  gattgacta  3000
ggtgacctg  gtgaagatc  gaaggatgc  caggcggaa  aagaaatca  gcaagagat  3060
aacacactc  agcaaaagc  gaatgagca  cagagtgtg  ttcagagga  tgctgcccc  3120
aacatgaag  ccatggaaa  gctggaaag  gtccgagac  agttccagg  gacctcaga  3180
gaatttgag  cagcacgaa  gcgagcaaa  aaagccaag  aggcatttg  acagataaa  3240
aaggagcgc  ttgaccgat  caatgcttg  tttgaatct  tggctacca  tattgatga  3300
atctacaag  ctctgtccc  taacagcag  gcccaggca  tcttgggcc  cgagaatcc  3360
gaagagccc  atttggatg  tatcaacta  aactgtgta  ctcctggca  acgtttccg  3420
cctatggac  atttgtcag  cggggagaa  acagttgcc  cactggcct  gctttttgc  3480
attcacagc  acaagccag  ccccttctt  gtcctggat  agattgatg  tgccttgga  3540
aacaccaac  ttggcaagg  ggcaaatta  atcaaggag  agtcaactt  caacttcca  3600
gccattgtt  tctctctca  ggaggaatt  tacaccaag  ctgagagcc  cattggagt  3660
tatcctgag  aaggagact  tgtgatcag  aaagtcctg  ccttcgacc  caccaagta  3720
ccagatgcc  accctaacc  caatgaaca  tagcaggaa  tctgtcttc  tgtctggat  3780
cctgaactg  ccttctatc  atcttctct  ctggatctc  tcacccact  tcatggatc  3840
cctggcacc  taccccctt  tgtttgtgt  catgtgtga  tgattgtgt  catgttaat  3900
tgtttgcaa  aataaatac  ggagactgg  ttt  3933



<210> 1377
<211> 1233
<212> PRT
<213> Rattus norvegicus
<308> CAA06377
<400> 1377

Met Gly Phe Leu Lys Leu Ile Glu Ile Glu Asn Phe Lys Ser Tyr Lys 
  1               5                  10                  15
Gly Arg Gln Ile Ile Gly Pro Phe Gln Arg Phe Thr Ala Ile Ile Gly 
             20                  25                  30
Pro Asn Gly Ser Gly Lys Ser Asn Leu Met Asp Ala Ile Ser Phe Val 
         35                  40                  45
Leu Gly Glu Lys Thr Ser Asn Leu Arg Val Lys Thr Leu Arg Asp Leu 
     50                  55                  60
Ile His Gly Ala Pro Val Gly Lys Pro Ala Ala Asn Arg Ala Phe Val 
 65                  70                  75                  80
Ser Met Val Tyr Ser Glu Glu Gly Ala Glu Asp Arg Thr Phe Ala Arg 
                 85                  90                  95
Val Ile Val Gly Gly Ser Ser Glu Tyr Lys Ile Asn Asn Lys Val Val 
             100                105                110
Gln Leu His Glu Tyr Ser Glu Glu Leu Glu Lys Leu Gly Ile Leu Ile 
         115                120                125
Lys Ala Arg Asn Phe Leu Val Phe Gln Gly Ala Val Glu Ser Ile Ala 
     130                135                140
Met Lys Asn Pro Lys Glu Arg Thr Ala Leu Phe Glu Glu Ile Ser Arg 
 145                150                155                160
Ser Gly Glu Leu Ala Gln Glu Tyr Asp Lys Arg Lys Lys Glu Met Val 
                 165                170                175
Lys Ala Glu Glu Asp Thr Gln Phe Asn Tyr His Arg Lys Lys Asn Ile 
             180                185                190
Ala Ala Glu Arg Lys Glu Ala Lys Gln Glu Lys Glu Glu Ala Asp Arg 
         195                200                205
Tyr Gln Ala Leu Lys Asp Glu Val Val Arg Ala Gln Val Gln Leu Gln 
     210                215                220
Leu Phe Lys Leu Tyr His Asn Glu Val Glu Ile Glu Lys Leu Asn Lys 
 225                230                235                240
Glu Leu Ala Ser Lys Asn Lys Glu Ile Glu Lys Asp Lys Lys Arg Met 
                 245                250                255
Asp Lys Val Glu Asp Glu Leu Lys Glu Lys Lys Lys Glu Leu Gly Lys 
             260                265                270
Met Met Arg Glu Gln Gln Gln Ile Glu Lys Glu Ile Lys Glu Lys Asp 
         275                280                285
Ser Glu Leu Asn Gln Lys Arg Pro Gln Tyr Ile Lys Ala Lys Glu Asn 
     290                295                300
Thr Ser His Lys Ile Lys Lys Leu Glu Ala Ala Lys Lys Ser Leu Gln 
 305                310                315                320
Asn Arg Gln Lys His Tyr Lys Lys Arg Lys Gly Asp Met Asp Glu Leu 
                 325                330                335
Glu Lys Glu Met Leu Ser Val Glu Lys Ala Arg Gln Glu Phe Glu Glu 
             340                345                350
Arg Met Glu Glu Glu Ser Gln Ser Gln Gly Arg Asp Leu Thr Leu Glu 
         355                360                365
Glu Asn Gln Val Lys Lys Tyr His Arg Leu Lys Glu Glu Ala Ser Lys 
     370                375                380
Arg Ala Ala Thr Leu Ala Gln Glu Leu Glu Lys Phe Asn Arg Asp Gln 
 385                390                395                400
Lys Ala Asp Gln Asp Arg Leu Asp Leu Glu Glu Arg Lys Lys Val Glu 
                 405                410                415
Thr Glu Ala Lys Ile Lys Gln Lys Leu Arg Glu Ile Glu Glu Asn Gln 
             420                425                430
Lys Arg Ile Glu Lys Leu Glu Glu Tyr Ile Thr Thr Ser Lys Gln Ser 
         435                440                445
Leu Glu Glu Gln Lys Lys Leu Glu Gly Glu Leu Thr Glu Glu Val Glu 
     450                455                460
Met Ala Lys Arg Arg Ile Asp Glu Ile Asn Lys Glu Leu Asn Gln Val 
 465                470                475                480
Met Glu Gln Leu Gly Asp Ala Arg Ile Asp Arg Gln Glu Ser Ser Arg 
                 485                490                495
Gln Gln Arg Lys Ala Glu Ile Met Glu Ser Ile Lys Arg Leu Tyr Pro 
             500                505                510
Gly Ser Val Tyr Gly Arg Leu Ile Asp Leu Cys Gln Pro Thr Gln Lys 
         515                520                525
Lys Tyr Gln Ile Ala Val Thr Lys Val Leu Gly Lys Asn Met Asp Ala 
     530                535                540
Ile Ile Val Asp Ser Glu Lys Thr Gly Arg Asp Cys Ile Gln Tyr Ile 
 545                550                555                560
Lys Glu Gln Arg Gly Glu Pro Glu Thr Phe Leu Pro Leu Asp Tyr Leu 
                 565                570                575
Glu Val Lys Pro Thr Asp Glu Lys Leu Arg Glu Leu Lys Gly Ala Lys 
             580                585                590
Leu Val Ile Asp Val Ile Arg Tyr Glu Pro Pro His Ile Lys Lys Ala 
         595                600                605
Leu Gln Tyr Ala Cys Gly Asn Ala Leu Val Cys Asp Asn Val Glu Asp 
     610                615                620
Ala Arg Arg Ile Ala Phe Gly Gly His Gln Arg His Lys Thr Val Ala 
 625                630                635                640
Leu Asp Gly Thr Leu Phe Gln Lys Ser Gly Val Ile Ser Gly Gly Ala 
                 645                650                655
Ser Asp Leu Lys Ala Lys Ala Arg Arg Trp Asp Glu Lys Ala Val Asp 
             660                665                670
Lys Leu Lys Glu Lys Lys Glu Arg Leu Thr Glu Glu Leu Lys Glu Gln 
         675                680                685
Met Lys Ala Lys Arg Lys Glu Ala Glu Leu Arg Gln Val Gln Ser Gln 
     690                695                700
Ala His Gly Leu Gln Met Arg Leu Lys Tyr Ser Gln Ser Asp Leu Glu 
 705                710                715                720
Gln Thr Lys Thr Arg His Leu Ala Leu Asn Leu Gln Glu Lys Ser Lys 
                 725                730                735
Leu Glu Ser Glu Leu Ala Asn Phe Gly Pro Arg Ile Asn Asp Ile Lys 
             740                745                750
Arg Ile Ile Gln Ser Arg Glu Arg Glu Met Lys Asp Leu Lys Glu Lys 
         755                760                765
Met Asn Gln Val Glu Asp Glu Val Phe Glu Glu Phe Cys Arg Glu Ile 
     770                775                780
Gly Val Arg Asn Ile Arg Glu Phe Glu Glu Glu Lys Val Lys Arg Gln 
 785                790                795                800
Asn Glu Ile Ala Lys Lys Arg Leu Glu Phe Glu Asn Gln Lys Thr Arg 
                 805                810                815
Leu Gly Ile Gln Leu Asp Phe Glu Lys Asn Gln Leu Lys Glu Asp Gln 
             820                825                830
Asp Lys Val His Met Trp Glu Gln Thr Val Lys Lys Asp Glu Asn Glu 
         835                840                845
Ile Glu Lys Leu Lys Lys Glu Glu Gln Arg His Met Lys Ile Ile Asp 
     850                855                860
Glu Thr Met Ala Gln Leu Gln Asp Leu Lys Asn Gln His Leu Ala Lys 
 865                870                875                880
Lys Ser Glu Val Asn Asp Lys Asn His Glu Met Glu Glu Ile Arg Lys 
                 885                890                895
Lys Leu Gly Gly Ala Asn Lys Glu Met Thr His Leu Gln Lys Glu Val 
             900                905                910
Thr Ala Ile Glu Thr Lys Leu Glu Gln Lys Arg Ser Asp Arg His Asn 
         915                920                925
Leu Leu Gln Ala Cys Lys Met Gln Asp Ile Lys Leu Pro Leu Ser Lys 
     930                935                940
Gly Thr Met Asp Asp Ile Ser Gln Glu Glu Gly Gly Ser Gln Gly Glu 
 945                950                955                960
Glu Ser Val Ser Gly Ser Gln Arg Thr Ser Ser Ile Tyr Ala Arg Glu 
                 965                970                975
Ala Leu Ile Glu Ile Asp Tyr Gly Asp Leu Cys Glu Asp Leu Lys Asp 
             980                985                990
Ala Gln Ala Glu Glu Glu Ile Lys Gln Glu Met Asn Thr Leu Gln Gln 
         995                1000                1005
Lys Leu Asn Glu Gln Gln Ser Val Leu Gln Arg Ile Ala Ala Pro Asn 
     1010                1015                1020
Met Lys Ala Met Glu Lys Leu Glu Ser Val Arg Asp Lys Phe Gln Glu 
 1025                1030                1035                1040
Thr Ser Asp Glu Phe Glu Ala Ala Arg Lys Arg Ala Lys Lys Ala Lys 
                 1045                1050                1055
Gln Ala Phe Glu Gln Ile Lys Lys Glu Arg Phe Asp Arg Phe Asn Ala 
             1060                1065                1070
Cys Phe Glu Ser Val Ala Thr Asn Ile Asp Glu Ile Tyr Lys Ala Leu 
         1075                1080                1085
Ser Arg Asn Ser Ser Ala Gln Ala Phe Leu Gly Pro Glu Asn Pro Glu 
     1090                1095                1100
Glu Pro Tyr Leu Asp Gly Ile Asn Tyr Asn Cys Val Ala Pro Gly Lys 
 1105                1110                1115                1120
Arg Phe Arg Pro Met Asp Asn Leu Ser Gly Gly Glu Lys Thr Val Ala 
                 1125                1130                1135
Ala Leu Ala Leu Leu Phe Ala Ile His Ser Tyr Lys Pro Ala Pro Phe 
             1140                1145                1150
Phe Val Leu Asp Glu Ile Asp Ala Ala Leu Asp Asn Thr Asn Ile Gly 
         1155                1160                1165
Lys Val Ala Asn Tyr Ile Lys Glu Gln Ser Thr Cys Asn Phe Gln Ala 
     1170                1175                1180
Ile Val Ile Ser Leu Lys Glu Glu Phe Tyr Thr Lys Ala Glu Ser Leu 
 1185                1190                1195                1200
Ile Gly Val Tyr Pro Glu Gln Gly Asp Cys Val Ile Ser Lys Val Leu 
                 1205                1210                1215
Thr Phe Asp Leu Thr Lys Tyr Pro Asp Ala Asn Pro Asn Pro Asn Glu 
             1220                1225                1230
Gln 
         1235



<210> 1378
<211> 5825
<212> DNA
<213> Homo sapiens
<308> D80000
<400> 1378

atggggttc  tgaaactga  tgagattga  aactttaag  cgtacaagg  tcgacagat  60
atcggacca  ttcagaggt  caccgccat  attggaccc  atggctctg  taagtcaaa  120
ctcatggat  ccatcagct  tgtgctagg  gaaaaaacc  gcaacctgc  ggtaaagac  180
ctgcgggac  tgatccatg  agctcctgt  ggcaagcca  ctgccaacc  ggcctttgt  240
agcatggtc  actctgagg  gggtgctga  gaccgtacc  ttgcccgtg  cattgtagg  300
ggttcttct  agtacaaga  caacaacaa  gtggtccaa  tacatgagt  cagtgagga  360
ttagagaag  tgggcattc  catcaaagc  cgtaacttc  tcgttttcc  gggtgctgt  420
gaatctatt  ccatgaaga  ccccaaaga  aggacagct  tatttgaag  gattagtcg  480
tctggggag  tggcgcagg  gtatgacaa  cgaaagaag  aaatggtga  ggctgaaga  540
gacacacag  ttaattacc  tcgcaagaa  aatattgcg  ctgaacgca  ggaagcaaa  600
caggagaaa  aagaggctg  ccggtacca  cgcctgaag  atgaggtag  acgggctca  660
gtacagctg  agctcttta  gctttacca  aatgaagtg  aaattgaga  gctcaacaa  720
gaactggcc  caaagaaca  ggagatcga  aaggacaag  agcgtatgg  caaggtgga  780
gatgaactg  aggagaaga  gaaggagct  ggcaaaatg  tgcgggagc  gcagcagat  840
gagaaggag  tcaaggaga  ggactcaga  ttgaaccag  agcggcctc  gtacatcaa  900
gccaaggag  acacctccc  caaaatcaa  aagctggaa  cagccaaga  gtctctgca  960
aatgctcag  agcactaca  gaagcgtaa  ggtgacatg  atgagctgg  gaaggagat  1020
ctgtcagtg  agaaggctc  gcaggagtt  gaagaacgg  tggaagaag  gagtcagag  1080
cagggcaga  atttgacgt  ggaggagaa  caggtgaag  aataccacc  gttgaaaga  1140
gaagccagc  agagagcag  taccctggc  caggagctg  agaaattca  tcgagacca  1200
aaagctgac  aggaccgtc  ggatctgga  gaacggaag  aagtagaga  agaggccaa  1260
atcaagcaa  agctgcggg  aattgaaga  aatcagaag  ggattgaga  actggagga  1320
tacatcacc  ctagcaagc  gtccctaga  gagcagaag  agctagagg  ggagctgac  1380
gaggaggtg  agatggcca  gcggcgtat  gatgaaatc  ataaggagc  gaaccaggt  1440
atggagcag  taggggatg  ccgcatcga  cgccaggag  gcagccgcc  gcagcgaaa  1500
gcagagata  tggaaagca  caagcgcct  taccctggc  ctgtgtacg  ccgcctcat  1560
gacctatgc  agcccacac  aaagaagta  cagattgct  taaccaagg  tttgggcaa  1620
aacatggat  ccattattg  ggactcgga  aagacaggc  gggactgta  tcagtatat  1680
aaggagcag  gtggggagc  tgagacctt  ttgcctctt  actacctgg  ggtgaagcc  1740
acagatgag  aactccggg  gctgaaggg  gccaagcta  tgattgatg  gattcgcta  1800
gagccacct  atatcaaaa  ggccctgca  tatgcttgt  gcaatgccc  tgtctgtga  1860
aacgtggaa  atgcccgcc  cattgcctt  ggaggccac  agcgccaca  gacagtggc  1920
ctggatgga  ccctattcc  gaagtcagg  gtgatctct  gtggggcca  tgacctgaa  1980
gccaaggca  ggcgctggg  tgagaaagc  gtagacaag  tgaaagaga  gaaggagcg  2040
ttgacagag  agctgaaag  gcagatgaa  gcaaaacgg  aagaggcag  gctgcgtca  2100
gtgcagtct  aggcccatg  actgcagat  cggctcaag  actcccaga  tgacctaga  2160
cagaccaag  cacgacatc  agccctgaa  ctgcaggaa  aatccaagc  ggagagtga  2220
ctagccaac  ttgggcctc  cattaatga  atcaagagg  tcattcaga  ccgagagag  2280
gaaatgaaa  acttgaagg  gaagatgaa  caggtagag  atgaggtgt  tgaagagtt  2340
tgtcgggag  ttggtgtgc  caacatccg  gagtttgag  aagaaaagg  gaaacggca  2400
aatgaaatc  ccaagaagc  tttggagtt  gagaatcag  agactcgct  gggcattca  2460
ttggatttt  aaaagaacc  actgaagga  gaccaagat  aagtacaca  gtgggagca  2520
acagtgaaa  aagatgaaa  tgagataga  aagctcaaa  aggaggaac  aagacacat  2580
aagatcata  atgagacca  ggctcagct  caagacctg  agaatcagc  tctggccaa  2640
aagtcggaa  tgaatgaca  gaatcatga  atggaggag  ttcgtaaga  actcggggg  2700
gccaacaag  aaatgaccc  tttacagaa  gaggtgaca  ccattgaga  caagcttga  2760
cagaagcgc  gtgaccgtc  caacttgct  caggcctgt  agatgcagg  cattaagtt  2820
ccactgtca  aaggcacca  ggatgatat  agtcaggaa  agggtagct  ccaggggga  2880
gactcagtg  gtggttcac  gagaatttc  agtatctat  cacgagagg  cctcattga  2940
attgactac  gtgatctgt  tgaggatct  aaggatgcc  aggctgagg  agagatcaa  3000
caagagatg  acacactgc  gcagaagct  aatgagcag  agagtgtgc  tcagcgtat  3060
gccgccccc  acatgaagg  catggaaaa  ctggaaagt  tccgagaca  gttccagga  3120
acctcagat  agtttgaag  agcccgaaa  cgagcaaag  aggccaagc  ggcattcga  3180
cagatcaag  aggagcgct  tgaccgctt  aatgcttgt  ttgaatctg  ggctaccaa  3240
attgatgag  tctataagg  cctgtcccg  aatagcagt  cccaggcat  cctgggccc  3300
gagaaccct  aagagccct  cttggatgg  atcaactac  actgtgtgg  tcctgggaa  3360
cgcttccgg  ctatggaca  cttgtcagg  ggggagaag  cagtggcag  tctggccct  3420
ctctttgcc  tccacagct  caagccagc  cccttcttc  tcctggatg  gattgatgc  3480
gccttggat  acaccaaca  tggcaaggt  gcaaattac  tcaaggagc  gtcgacttg  3540
aacttccag  ccatcgtca  ctctctcaa  gaggagttc  acaccaagg  cgagagcct  3600
attggagtc  atcctgagc  aggggactg  gtgatcagc  aagtcctga  cttcgacct  3660
accaagtac  cagatgcca  ccccaaccc  aatgagcag  agcagtatt  ttgccctcc  3720
gccctgtct  gatccctaa  ctgtccctc  cccaatctc  ggatatttg  ctcccaacc  3780
tccccctac  tcctggccc  ttttggtgt  gtcatggga  ttaggcact  ctaatcaag  3840
atgaagagg  acagaggtg  tgttaggtc  ggagcaaaa  ttcctgaac  acagggagt  3900
ttctggcct  tgaaaggag  tgctgagct  aacagggcc  tctgttcat  acacacacc  3960
ccttcctcc  cctcatcac  cataatcgt  ggccccttg  gcctcttgc  cactgtgtg  4020
gtgggtatg  atgtgtgta  gtatgtatc  gcatgtgtg  atgtgagta  gtttgcaaa  4080
taataaagg  tattggaga  ctgttttag  aggagccta  gctgaattt  attccaaga  4140
agcttagga  gacagcacc  ctgagctgg  caaaggtac  caggacctc  taggagtct  4200
aggcagtta  ctgaaactg  cttcattca  tcatttgtg  attcattca  ttatgtatt  4260
atcagacac  taccgaaca  cctctattt  tcaggctct  tgcttggaa  acagagttg  4320
atcagacat  atctctacc  tcctagtaa  gagatacag  gggttcatg  atgactata  4380
ttagctgaa  gtcatatgt  ctttgaatt  gagaagtgg  tgatcccct  taggcttcc  4440
ggaggtcac  tttaagcta  accttgaca  attggtagg  tttggtcag  cactaggag  4500
ggagcatga  ctctgggga  agacagtta  gggttctgg  cccactttt  atcacttac  4560
agttgtttg  ccttgggca  gtcatttga  cttctgtgc  tcagtttcc  catctgtaa  4620
atggggcta  caatattac  tacctcata  gatttaatg  tgtcaagct  ctcactgga  4680
gccttatcc  ttcgtggag  ccactaggt  ccgacccct  agaatataa  cctcatgcc  4740
ggacccctg  gagcttctg  tcccagcta  tagggacag  agaagcctc  aaatctgga  4800
ggtgctgaa  gccctgctg  ctgggaaag  ttcagggca  tgatggggt  tacctggta  4860
gcggagggc  tgaggaaac  tgtagcttc  atcatgtct  gtaaccggg  gcctgagcc  4920
caatctggg  tgtgaggaa  taggggaga  gtatcctgg  ccacatccc  gcctaacac  4980
tgtgaggtt  attttagga  ctaacctca  tagctataa  gatcatgca  aggcagcaa  5040
gccgggtgc  atgagctca  cctttactc  ttcacatac  ccatcacac  ttaattcca  5100
tctgtatat  gctttttaa  agttaagtc  attctaatt  cccaaatat  catgaattc  5160
ttctccttt  gagaagtta  attgttaaa  atagtctca  tcagctacc  accactcct  5220
gatccttcc  ttcttagtg  ctgttgttt  ttgtacttc  gtttagact  tgttttaat  5280
cttgtacgt  catatgtga  ctcattgga  atattgtgt  tttaatgca  atgatatat  5340
gaattgttt  gcaatttgt  ttctttgct  aacgatgtt  ttgagatct  tgcatgtta  5400
ttaatgtag  tcaatccat  ttctgtaat  gctgtatag  ttgtcatca  atgattacc  5460
cattttact  acgcatttc  tttgtgatg  acattaaga  tgtttttag  ttttgctat  5520
acaaaatac  acacaggag  atcactatg  ctgtgtgaa  gtatatgta  gaaagttta  5580
ctagggttg  ttcctagaa  tggaattgc  aagtcatag  atatttata  attggtttt  5640
aataatact  ccaaattgc  ctcctgtac  atttactca  tatttttct  gaggttgat  5700
tgaggtcta  cattgttat  ctatatcat  ttcatccca  gtagtgata  ctgtgaaat  5760
acaggtttg  tgtgtgcta  ttatgtatt  ttctaatac  tattaaaag  cataactat  5820
aaaac  5825



<210> 1379
<211> 1233
<212> PRT
<213> Homo sapiens
<308> NP_006297
<400> 1379

Met Gly Phe Leu Lys Leu Ile Glu Ile Glu Asn Phe Lys Ser Tyr Lys 
  1               5                  10                  15
Gly Arg Gln Ile Ile Gly Pro Phe Gln Arg Phe Thr Ala Ile Ile Gly 
             20                  25                  30
Pro Asn Gly Ser Gly Lys Ser Asn Leu Met Asp Ala Ile Ser Phe Val 
         35                  40                  45
Leu Gly Glu Lys Thr Ser Asn Leu Arg Val Lys Thr Leu Arg Asp Leu 
     50                  55                  60
Ile His Gly Ala Pro Val Gly Lys Pro Ala Ala Asn Arg Ala Phe Val 
 65                  70                  75                  80
Ser Met Val Tyr Ser Glu Glu Gly Ala Glu Asp Arg Thr Phe Ala Arg 
                 85                  90                  95
Val Ile Val Gly Gly Ser Ser Glu Tyr Lys Ile Asn Asn Lys Val Val 
             100                105                110
Gln Leu His Glu Tyr Ser Glu Glu Leu Glu Lys Leu Gly Ile Leu Ile 
         115                120                125
Lys Ala Arg Asn Phe Leu Val Phe Gln Gly Ala Val Glu Ser Ile Ala 
     130                135                140
Met Lys Asn Pro Lys Glu Arg Thr Ala Leu Phe Glu Glu Ile Ser Arg 
 145                150                155                160
Ser Gly Asp Val Ala Gln Glu Tyr Asp Lys Arg Lys Lys Glu Met Val 
                 165                170                175
Lys Ala Glu Glu Asp Thr Gln Phe Asn Tyr His Arg Lys Lys Asn Ile 
             180                185                190
Ala Ala Glu Arg Lys Glu Ala Lys Gln Glu Lys Glu Glu Ala Asp Arg 
         195                200                205
Tyr Gln Arg Leu Lys Asp Glu Val Val Arg Ala Gln Val Gln Leu Gln 
     210                215                220
Leu Phe Lys Leu Tyr His Asn Glu Val Glu Ile Glu Lys Leu Asn Lys 
 225                230                235                240
Glu Leu Ala Ser Lys Asn Lys Glu Ile Glu Lys Asp Lys Lys Arg Met 
                 245                250                255
Asp Lys Val Glu Asp Glu Leu Lys Glu Lys Lys Lys Glu Leu Gly Lys 
             260                265                270
Met Met Arg Glu Gln Gln Gln Ile Glu Lys Glu Ile Lys Glu Lys Asp 
         275                280                285
Ser Glu Leu Asn Gln Lys Arg Pro Gln Tyr Ile Lys Ala Lys Glu Asn 
     290                295                300
Thr Ser His Lys Ile Lys Lys Leu Glu Ala Ala Lys Lys Ser Leu Gln 
 305                310                315                320
Asn Ala Gln Lys His Tyr Lys Lys Arg Lys Gly Asp Met Asp Glu Leu 
                 325                330                335
Glu Lys Glu Met Leu Ser Val Glu Lys Ala Arg Gln Glu Phe Glu Glu 
             340                345                350
Arg Met Glu Glu Glu Ser Gln Ser Gln Gly Arg Asp Leu Thr Leu Glu 
         355                360                365
Glu Asn Gln Val Lys Lys Tyr His Arg Leu Lys Glu Glu Ala Ser Lys 
     370                375                380
Arg Ala Ala Thr Leu Ala Gln Glu Leu Glu Lys Phe Asn Arg Asp Gln 
 385                390                395                400
Lys Ala Asp Gln Asp Arg Leu Asp Leu Glu Glu Arg Lys Lys Val Glu 
                 405                410                415
Thr Glu Ala Lys Ile Lys Gln Lys Leu Arg Glu Ile Glu Glu Asn Gln 
             420                425                430
Lys Arg Ile Glu Lys Leu Glu Glu Tyr Ile Thr Thr Ser Lys Gln Ser 
         435                440                445
Leu Glu Glu Gln Lys Lys Leu Glu Gly Glu Leu Thr Glu Glu Val Glu 
     450                455                460
Met Ala Lys Arg Arg Ile Asp Glu Ile Asn Lys Glu Leu Asn Gln Val 
 465                470                475                480
Met Glu Gln Leu Gly Asp Ala Arg Ile Asp Arg Gln Glu Ser Ser Arg 
                 485                490                495
Gln Gln Arg Lys Ala Glu Ile Met Glu Ser Ile Lys Arg Leu Tyr Pro 
             500                505                510
Gly Ser Val Tyr Gly Arg Leu Ile Asp Leu Cys Gln Pro Thr Gln Lys 
         515                520                525
Lys Tyr Gln Ile Ala Val Thr Lys Val Leu Gly Lys Asn Met Asp Ala 
     530                535                540
Ile Ile Val Asp Ser Glu Lys Thr Gly Arg Asp Cys Ile Gln Tyr Ile 
 545                550                555                560
Lys Glu Gln Arg Gly Glu Pro Glu Thr Phe Leu Pro Leu Asp Tyr Leu 
                 565                570                575
Glu Val Lys Pro Thr Asp Glu Lys Leu Arg Glu Leu Lys Gly Ala Lys 
             580                585                590
Leu Val Ile Asp Val Ile Arg Tyr Glu Pro Pro His Ile Lys Lys Ala 
         595                600                605
Leu Gln Tyr Ala Cys Gly Asn Ala Leu Val Cys Asp Asn Val Glu Asp 
     610                615                620
Ala Arg Arg Ile Ala Phe Gly Gly His Gln Arg His Lys Thr Val Ala 
 625                630                635                640
Leu Asp Gly Thr Leu Phe Gln Lys Ser Gly Val Ile Ser Gly Gly Ala 
                 645                650                655
Ser Asp Leu Lys Ala Lys Ala Arg Arg Trp Asp Glu Lys Ala Val Asp 
             660                665                670
Lys Leu Lys Glu Lys Lys Glu Arg Leu Thr Glu Glu Leu Lys Glu Gln 
         675                680                685
Met Lys Ala Lys Arg Lys Glu Ala Glu Leu Arg Gln Val Gln Ser Gln 
     690                695                700
Ala His Gly Leu Gln Met Arg Leu Lys Tyr Ser Gln Ser Asp Leu Glu 
 705                710                715                720
Gln Thr Lys Thr Arg His Leu Ala Leu Asn Leu Gln Glu Lys Ser Lys 
                 725                730                735
Leu Glu Ser Glu Leu Ala Asn Phe Gly Pro Arg Ile Asn Asp Ile Lys 
             740                745                750
Arg Ile Ile Gln Ser Arg Glu Arg Glu Met Lys Asp Leu Lys Glu Lys 
         755                760                765
Met Asn Gln Val Glu Asp Glu Val Phe Glu Glu Phe Cys Arg Glu Ile 
     770                775                780
Gly Val Arg Asn Ile Arg Glu Phe Glu Glu Glu Lys Val Lys Arg Gln 
 785                790                795                800
Asn Glu Ile Ala Lys Lys Arg Leu Glu Phe Glu Asn Gln Lys Thr Arg 
                 805                810                815
Leu Gly Ile Gln Leu Asp Phe Glu Lys Asn Gln Leu Lys Glu Asp Gln 
             820                825                830
Asp Lys Val His Met Trp Glu Gln Thr Val Lys Lys Asp Glu Asn Glu 
         835                840                845
Ile Glu Lys Leu Lys Lys Glu Glu Gln Arg His Met Lys Ile Ile Asp 
     850                855                860
Glu Thr Met Ala Gln Leu Gln Asp Leu Lys Asn Gln His Leu Ala Lys 
 865                870                875                880
Lys Ser Glu Val Asn Asp Lys Asn His Glu Met Glu Glu Ile Arg Lys 
                 885                890                895
Lys Leu Gly Gly Ala Asn Lys Glu Met Thr His Leu Gln Lys Glu Val 
             900                905                910
Thr Ala Ile Glu Thr Lys Leu Glu Gln Lys Arg Ser Asp Arg His Asn 
         915                920                925
Leu Leu Gln Ala Cys Lys Met Gln Asp Ile Lys Leu Pro Leu Ser Lys 
     930                935                940
Gly Thr Met Asp Asp Ile Ser Gln Glu Glu Gly Ser Ser Gln Gly Glu 
 945                950                955                960
Asp Ser Val Ser Gly Ser Gln Arg Ile Ser Ser Ile Tyr Ala Arg Glu 
                 965                970                975
Ala Leu Ile Glu Ile Asp Tyr Gly Asp Leu Cys Glu Asp Leu Lys Asp 
             980                985                990
Ala Gln Ala Glu Glu Glu Ile Lys Gln Glu Met Asn Thr Leu Gln Gln 
         995                1000                1005
Lys Leu Asn Glu Gln Gln Ser Val Leu Gln Arg Ile Ala Ala Pro Asn 
     1010                1015                1020
Met Lys Ala Met Glu Lys Leu Glu Ser Val Arg Asp Lys Phe Gln Glu 
 1025                1030                1035                1040
Thr Ser Asp Glu Phe Glu Ala Ala Arg Lys Arg Ala Lys Lys Ala Lys 
                 1045                1050                1055
Gln Ala Phe Glu Gln Ile Lys Lys Glu Arg Phe Asp Arg Phe Asn Ala 
             1060                1065                1070
Cys Phe Glu Ser Val Ala Thr Asn Ile Asp Glu Ile Tyr Lys Ala Leu 
         1075                1080                1085
Ser Arg Asn Ser Ser Ala Gln Ala Phe Leu Gly Pro Glu Asn Pro Glu 
     1090                1095                1100
Glu Pro Tyr Leu Asp Gly Ile Asn Tyr Asn Cys Val Ala Pro Gly Lys 
 1105                1110                1115                1120
Arg Phe Arg Pro Met Asp Asn Leu Ser Gly Gly Glu Lys Thr Val Ala 
                 1125                1130                1135
Ala Leu Ala Leu Leu Phe Ala Ile His Ser Tyr Lys Pro Ala Pro Phe 
             1140                1145                1150
Phe Val Leu Asp Glu Ile Asp Ala Ala Leu Asp Asn Thr Asn Ile Gly 
         1155                1160                1165
Lys Val Ala Asn Tyr Ile Lys Glu Gln Ser Thr Cys Asn Phe Gln Ala 
     1170                1175                1180
Ile Val Ile Ser Leu Lys Glu Glu Phe Tyr Thr Lys Ala Glu Ser Leu 
 1185                1190                1195                1200
Ile Gly Val Tyr Pro Glu Gln Gly Asp Cys Val Ile Ser Lys Val Leu 
                 1205                1210                1215
Thr Phe Asp Leu Thr Lys Tyr Pro Asp Ala Asn Pro Asn Pro Asn Glu 
             1220                1225                1230
Gln 
         1235



<210> 1380
<211> 1126
<212> DNA
<213> Rattus norvegicus
<308> AJ005394
<400> 1380

ctgcaagga  cttcaactc  gccatcctg  tttcccaga  ggcgaatac  gggtcgatc  60
caaccaagg  tgctccagg  actccttca  agtctactg  aatttcaca  ctggagggt  120
cacgtgcgt  ttccctgac  agaagtctg  gggagccag  atcacttct  ggcccaaag  180
aaacccagg  tcctggttc  gtgaattca  gcgtgggaa  ctgctctcc  atgtggatg  240
tgaaggcaa  cctgtgggc  tggtacaaa  gaccttcct  cggctgctg  gtgcctctg  300
ccagcagaa  atcacctac  actgctacc  gtccgtggc  tggcaggat  ccgccacag  360
cagctacga  aaggctatc  gcttcttgg  ctccaacga  gaggaaatg  cttatgata  420
caaccccta  atccgtgcc  tggtggatg  ctgtgctac  aagaaaggc  accagaaga  480
ggtgctgga  attgacacg  ccaaagttg  gcaagtccc  attgtggac  tcatgttca  540
cgactttgg  gaagcctca  agaaatttg  atttgaagt  gggccacct  gcttcctag  600
ctaggagct  ctgagccca  cggtctcca  agcaacctc  tgacctcag  accccacct  660
tgggcgtcc  gtgcacggc  catcccgga  agtgaacct  tctcacccc  gcctgcctg  720
ctcatctgt  cctcggagc  tccgtggcg  tggacccca  gcccagaga  aacaaaggg  780
aagagccgt  tccccacgg  gccgaatca  atgacctag  cacaccaca  cctcttgcc  840
cgcttcagc  ctccggata  gttcatcga  ggtgttaat  gaccgttgg  cgggagtgg  900
gcgggacag  atttgaaaa  cacttttta  aaaaattca  cttgaagat  tgtattccc  960
ctgaccttc  aaagatgtt  tgaggtggt  ttgtaaagg  caccaaagc  tccatttaa  1020
aaagaaaaa  aaaaaaaaa  ccaaccctc  acatatcca  tcagaggcc  aatgtcatt  1080
cacatgtgc  tttccgatg  attaaaggt  cttatgttt  tgtgag  1126



<210> 1381
<211> 200
<212> PRT
<213> Rattus norvegicus
<308> CAA06509
<400> 1381

Cys Lys Asp Leu Gln Leu Cys His Pro Asp Phe Pro Asp Gly Glu Tyr 
  1               5                  10                  15
Trp Val Asp Pro Asn Gln Gly Cys Ser Arg Asp Ser Phe Lys Val Tyr 
             20                  25                  30
Cys Asn Phe Thr Ala Gly Gly Ser Thr Cys Val Phe Pro Asp Lys Lys 
         35                  40                  45
Ser Glu Gly Ala Arg Ile Thr Ser Trp Pro Lys Glu Asn Pro Gly Ser 
     50                  55                  60
Trp Phe Ser Glu Phe Lys Arg Gly Lys Leu Leu Ser Tyr Val Asp Ala 
 65                  70                  75                  80
Glu Gly Asn Pro Val Gly Val Val Gln Met Thr Phe Leu Arg Leu Leu 
                 85                  90                  95
Ser Ala Ser Ala Gln Gln Asn Ile Thr Tyr Asn Cys Tyr Gln Ser Val 
             100                105                110
Ala Trp Gln Asp Ala Ala Thr Gly Ser Tyr Asp Lys Ala Ile Arg Phe 
         115                120                125
Leu Gly Ser Asn Asp Glu Glu Met Ser Tyr Asp Asn Asn Pro Tyr Ile 
     130                135                140
Arg Ala Leu Val Asp Gly Cys Ala Thr Lys Lys Gly Tyr Gln Lys Thr 
 145                150                155                160
Val Leu Glu Ile Asp Thr Pro Lys Val Glu Gln Val Pro Ile Val Asp 
                 165                170                175
Ile Met Phe Thr Asp Phe Gly Glu Ala Ser Gln Lys Phe Gly Phe Glu 
             180                185                190
Val Gly Pro Pro Cys Phe Leu Gly 
         195                200



<210> 1382
<211> 2377
<212> DNA
<213> Homo sapiens
<308> BC008760
<400> 1382

ggcacgagg  tgggccccc  gggtccccc  ggcccccga  gaccctccg  agctccagg  60
gctgatggc  cacaaggtc  cccaggtgg  ataggaaac  ctggtgcag  gggagagaa  120
ggcgagcct  gcgaagcag  tgagcctgg  cttccggga  aaggcggcc  cccgggacc  180
aaaggagaa  ggggagaga  gggcgagtc  ggcccttca  gtgctgccg  accccctgg  240
cccaaaggc  ctcccggag  tgatggtcc  aaaggcagc  ctggcccag  gggttttcc  300
ggagatcct  gcccccccg  agagcctgg  cccgcgggt  aagatggtc  ccctggtga  360
aaaggagat  atggtgaac  cgggcagac  ggatccccc  gccctactg  tgaaccagg  420
ccatcgggg  ctccaggaa  aaggggtcc  ccaggcccc  caggccccg  aggcagaca  480
ggagagaaa  gggccaagg  agaagccgg  ttggaaggc  ctcctggga  gactggccc  540
atcggcccc  agggggccc  tgggaagcc  ggaccggat  gccttcgag  gatccctgg  600
cctgtggga  aacaaggtc  cccaggatc  ccaggcccg  acggtcccc  cggccccat  660
ggtccccca  gacttcccg  cctcaaagg  gattctggt  ccaaaggtg  aaagggtca  720
ccaggcctg  tcgggctca  cggtcctcc  ggtgaacag  gtgagaagg  cgaccgtgg  780
ctccctggc  cccagggct  ctccggtcc  aagggagaa  agggtatca  tggtccttc  840
ggcccgatt  ggcctcctg  gccccctgg  ctgccgggt  cgcctggtc  aaaaggtgc  900
aagggctcc  cgggtccaa  tggcccgaa  ggtgaggca  gccacccag  acccccagg  960
cccccgggc  ccccgggag  ggtcatcca  cccctgcca  tccaggcat  caggacgcg  1020
cggaacatc  acgccagcc  gctgctgga  gacgggaat  gcgagaact  cgtggacta  1080
gcggacggc  tggaagaga  cttcggctc  ctcaactct  tgaagctgg  gattgagca  1140
atgaaacgg  ccctgggca  gcagcagaa  cccgcccgc  cctgcaagg  cctgcagct  1200
tgccacccc  acttcccag  tggtgaata  tgggtcgat  ctaaccaag  atgctccag  1260
gattccttc  aggtttact  caacttcac  gccgggggg  cgacatgcg  cttccctga  1320
aagaagtcc  aaggggcca  aatcacttc  tggcccaaa  aaaacccgg  ctcctggtt  1380
agtgaattc  agcgtggga  actgctctc  tatgtggac  ccgagggca  ccctgtggg  1440
gtggtacag  tgaccttcc  gcggctgct  agcgcctct  cccaccaga  cgtcaccta  1500
cactgctac  agtcagtgg  ctggcagga  gcagccacg  gcagctacg  caaggccct  1560
cgcttcctg  gctccaacg  cgaggagat  tcctatgac  acaacccct  catccgcgc  1620
ctggtggac  gctgtgcta  caagaaagg  taccagaag  cggttctgg  gatcgacac  1680
cccaaagtg  agcaggtgc  catcgtgga  atcatgttc  atgacttcg  tgaagcgtc  1740
cagaaattt  gatttgaag  ggggccggc  tgcttcatg  gctaggagc  gccgagccc  1800
ggctcccga  agcaacctc  tgacctcag  atgccattc  ttcgtgagt  tcccgtgca  1860
gtcctgatc  tggacagtg  aggcttctc  ctcccctcc  acctgactt  atctacgcc  1920
cggcaccac  gggtgtggg  ccccagccc  gagagaaca  agggaagga  ccgcgcccc  1980
acctggagc  gaatcacat  acctagctg  accccagcg  ctgggcccg  cccacgctc  2040
gtccacacc  atgcgcccc  ggagcgggg  catgcctcc  gccccccag  tcgcccgac  2100
catcctgtt  gtgaatagg  ctcaggggt  gggggaggg  ctgccagat  tggacacta  2160
atttttttc  aaattcaac  tgaagatgt  tatttcccc  gaccttcaa  aaatgttcc  2220
aggtaagcc  cgtaaaggt  atcccacca  caccaaagc  tccgttttt  acaacctcc  2280
acacgatcc  tttagaggc  aaatgtcat  ctgcaggtg  cttcccgat  gattaaagg  2340
gcttatgtt  ttgtgaaaa  aaaaaaaaa  aaaaaaa  2377



<210> 1383
<211> 1838
<212> PRT
<213> Homo sapiens
<308> P20908
<400> 1383

Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 
  1               5                  10                  15
Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 
             20                  25                  30
Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 
         35                  40                  45
His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 
     50                  55                  60
Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 
 65                  70                  75                  80
Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 
                 85                  90                  95
Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 
             100                105                110
Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 
         115                120                125
Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 
     130                135                140
Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 
 145                150                155                160
Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 
                 165                170                175
Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 
             180                185                190
Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 
         195                200                205
Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 
     210                215                220
Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 
 225                230                235                240
Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 
                 245                250                255
Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 
             260                265                270
Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 
         275                280                285
Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 
     290                295                300
Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 
 305                310                315                320
Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 
                 325                330                335
Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 
             340                345                350
Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 
         355                360                365
Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 
     370                375                380
Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 
 385                390                395                400
Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 
                 405                410                415
Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 
             420                425                430
Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 
         435                440                445
Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 
     450                455                460
Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 
 465                470                475                480
Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 
                 485                490                495
Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 
             500                505                510
Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 
         515                520                525
Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 
     530                535                540
Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 
 545                550                555                560
Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 
                 565                570                575
Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 
             580                585                590
Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 
         595                600                605
Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 
     610                615                620
Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 
 625                630                635                640
Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 
                 645                650                655
Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 
             660                665                670
Gly Leu Pro Gly Lys Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 
         675                680                685
Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 
     690                695                700
Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 
 705                710                715                720
Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 
                 725                730                735
Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 
             740                745                750
Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 
         755                760                765
Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 
     770                775                780
Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 
 785                790                795                800
Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                 805                810                815
Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 
             820                825                830
Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 
         835                840                845
Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 
     850                855                860
Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 
 865                870                875                880
Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 
                 885                890                895
Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 
             900                905                910
Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 
         915                920                925
Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 
     930                935                940
Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 
 945                950                955                960
Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 
                 965                970                975
His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 
             980                985                990
Pro Gly Pro Pro Gly Val Val Gly Pro Gln Gly Pro Thr Gly Glu Thr 
         995                1000                1005
Gly Pro Met Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro Pro Gly 
     1010                1015                1020
Glu Gln Gly Leu Pro Gly Leu Ala Gly Lys Glu Gly Thr Lys Gly Asp 
 1025                1030                1035                1040
Pro Gly Pro Ala Gly Leu Pro Gly Lys Asp Gly Pro Pro Gly Leu Arg 
                 1045                1050                1055
Gly Phe Pro Gly Asp Arg Gly Leu Pro Gly Pro Val Gly Ala Leu Gly 
             1060                1065                1070
Leu Lys Gly Asn Glu Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Ser 
         1075                1080                1085
Pro Gly Glu Arg Gly Pro Ala Gly Ala Ala Gly Pro Ile Gly Ile Pro 
     1090                1095                1100
Gly Arg Pro Gly Pro Gln Gly Pro Pro Gly Pro Ala Gly Glu Lys Gly 
 1105                1110                1115                1120
Ala Pro Gly Glu Lys Gly Pro Gln Gly Pro Ala Gly Arg Asp Gly Leu 
                 1125                1130                1135
Gln Gly Pro Val Gly Leu Pro Gly Pro Ala Gly Pro Val Gly Pro Pro 
             1140                1145                1150
Gly Glu Asp Gly Asp Lys Gly Glu Ile Gly Glu Pro Gly Gln Lys Gly 
         1155                1160                1165
Ser Lys Gly Asp Lys Gly Glu Gln Gly Pro Pro Gly Pro Thr Gly Pro 
     1170                1175                1180
Gln Gly Pro Ile Gly Gln Pro Gly Pro Ser Gly Ala Asp Gly Glu Pro 
 1185                1190                1195                1200
Gly Pro Arg Gly Gln Gln Gly Leu Phe Gly Gln Lys Gly Asp Glu Gly 
                 1205                1210                1215
Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu 
             1220                1225                1230
Pro Gly Pro Pro Gly Glu Lys Gly Glu Thr Gly Asp Val Gly Gln Met 
         1235                1240                1245
Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Ser Gly Ala Pro Gly 
     1250                1255                1260
Ala Asp Gly Pro Gln Gly Pro Pro Gly Gly Ile Gly Asn Pro Gly Ala 
 1265                1270                1275                1280
Val Gly Glu Lys Gly Glu Pro Gly Glu Ala Gly Glu Pro Gly Pro Ser 
                 1285                1290                1295
Gly Arg Ser Gly Pro Pro Gly Pro Lys Gly Glu Arg Gly Glu Lys Gly 
             1300                1305                1310
Glu Ser Gly Pro Ser Gly Ala Ala Gly Pro Pro Gly Pro Lys Gly Pro 
         1315                1320                1325
Pro Gly Asp Asp Gly Pro Lys Gly Ser Pro Gly Pro Val Gly Phe Pro 
     1330                1335                1340
Gly Asp Pro Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly Gln Asp Gly 
 1345                1350                1355                1360
Pro Pro Gly Asp Lys Gly Asp Asp Gly Glu Pro Gly Gln Thr Gly Ser 
                 1365                1370                1375
Pro Gly Pro Thr Gly Glu Pro Gly Pro Ser Gly Pro Pro Gly Lys Arg 
             1380                1385                1390
Gly Pro Pro Gly Pro Ala Gly Pro Glu Gly Arg Gln Gly Glu Lys Gly 
         1395                1400                1405
Ala Lys Gly Glu Ala Gly Leu Glu Gly Pro Pro Gly Lys Thr Gly Pro 
     1410                1415                1420
Ile Gly Pro Gln Gly Ala Pro Gly Lys Pro Gly Pro Asp Gly Leu Arg 
 1425                1430                1435                1440
Gly Ile Pro Gly Pro Val Gly Glu Gln Gly Leu Pro Gly Ser Pro Gly 
                 1445                1450                1455
Pro Asp Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Leu Pro Gly Leu 
             1460                1465                1470
Lys Gly Asp Ser Gly Pro Lys Gly Glu Lys Gly His Pro Gly Leu Ile 
         1475                1480                1485
Gly Leu Ile Gly Pro Pro Gly Glu Gln Gly Glu Lys Gly Asp Arg Gly 
     1490                1495                1500
Leu Pro Gly Pro Gln Gly Ser Ser Gly Pro Lys Gly Glu Gln Gly Ile 
 1505                1510                1515                1520
Thr Gly Pro Ser Gly Pro Ile Gly Pro Pro Gly Pro Pro Gly Leu Pro 
                 1525                1530                1535
Gly Pro Pro Gly Pro Lys Gly Ala Lys Gly Ser Ser Gly Pro Thr Gly 
             1540                1545                1550
Pro Arg Gly Glu Ala Gly His Pro Gly Pro Pro Gly Pro Pro Gly Pro 
         1555                1560                1565
Pro Gly Glu Val Ile Gln Pro Leu Pro Ile Gln Ala Ser Arg Thr Arg 
     1570                1575                1580
Arg Asn Ile Asp Ala Ser Gln Leu Leu Asp Asp Gly Asn Gly Glu Asn 
 1585                1590                1595                1600
Tyr Val Asp Tyr Ala Asp Gly Met Glu Glu Ile Phe Gly Ser Leu Asn 
                 1605                1610                1615
Ser Leu Lys Leu Glu Ile Glu Gln Met Lys Arg Pro Leu Gly Thr Gln 
             1620                1625                1630
Gln Asn Pro Ala Arg Thr Cys Lys Asp Leu Gln Leu Cys His Pro Asp 
         1635                1640                1645
Phe Pro Asp Gly Glu Tyr Trp Val Asp Pro Asn Gln Gly Cys Ser Arg 
     1650                1655                1660
Asp Ser Phe Lys Val Tyr Cys Asn Phe Thr Ala Gly Gly Ser Thr Cys 
 1665                1670                1675                1680
Val Phe Pro Asp Lys Lys Ser Glu Gly Ala Arg Ile Thr Ser Trp Pro 
                 1685                1690                1695
Lys Glu Asn Pro Gly Ser Trp Phe Ser Glu Phe Lys Arg Gly Lys Leu 
             1700                1705                1710
Leu Ser Tyr Val Asp Ala Glu Gly Asn Pro Val Gly Val Val Gln Met 
         1715                1720                1725
Thr Phe Leu Arg Leu Leu Ser Ala Ser Ala His Gln Asn Val Thr Tyr 
     1730                1735                1740
His Cys Tyr Gln Ser Val Ala Trp Gln Asp Ala Ala Thr Gly Ser Tyr 
 1745                1750                1755                1760
Asp Lys Ala Leu Arg Phe Leu Gly Ser Asn Asp Glu Glu Met Ser Tyr 
                 1765                1770                1775
Asp Asn Asn Pro Tyr Ile Arg Ala Leu Val Asp Gly Cys Ala Thr Lys 
             1780                1785                1790
Lys Gly Tyr Gln Lys Thr Val Leu Glu Ile Asp Thr Pro Lys Val Glu 
         1795                1800                1805
Gln Val Pro Ile Val Asp Ile Met Phe Asn Asp Phe Gly Glu Ala Ser 
     1810                1815                1820
Gln Lys Phe Gly Phe Glu Val Gly Pro Ala Cys Phe Met Gly 
 1825                1830                1835



<210> 1384
<211> 1126
<212> DNA
<213> Rattus norvegicus
<308> AJ005394
<400> 1384

ctgcaagga  cttcaactc  gccatcctg  tttcccaga  ggcgaatac  gggtcgatc  60
caaccaagg  tgctccagg  actccttca  agtctactg  aatttcaca  ctggagggt  120
cacgtgcgt  ttccctgac  agaagtctg  gggagccag  atcacttct  ggcccaaag  180
aaacccagg  tcctggttc  gtgaattca  gcgtgggaa  ctgctctcc  atgtggatg  240
tgaaggcaa  cctgtgggc  tggtacaaa  gaccttcct  cggctgctg  gtgcctctg  300
ccagcagaa  atcacctac  actgctacc  gtccgtggc  tggcaggat  ccgccacag  360
cagctacga  aaggctatc  gcttcttgg  ctccaacga  gaggaaatg  cttatgata  420
caaccccta  atccgtgcc  tggtggatg  ctgtgctac  aagaaaggc  accagaaga  480
ggtgctgga  attgacacg  ccaaagttg  gcaagtccc  attgtggac  tcatgttca  540
cgactttgg  gaagcctca  agaaatttg  atttgaagt  gggccacct  gcttcctag  600
ctaggagct  ctgagccca  cggtctcca  agcaacctc  tgacctcag  accccacct  660
tgggcgtcc  gtgcacggc  catcccgga  agtgaacct  tctcacccc  gcctgcctg  720
ctcatctgt  cctcggagc  tccgtggcg  tggacccca  gcccagaga  aacaaaggg  780
aagagccgt  tccccacgg  gccgaatca  atgacctag  cacaccaca  cctcttgcc  840
cgcttcagc  ctccggata  gttcatcga  ggtgttaat  gaccgttgg  cgggagtgg  900
gcgggacag  atttgaaaa  cacttttta  aaaaattca  cttgaagat  tgtattccc  960
ctgaccttc  aaagatgtt  tgaggtggt  ttgtaaagg  caccaaagc  tccatttaa  1020
aaagaaaaa  aaaaaaaaa  ccaaccctc  acatatcca  tcagaggcc  aatgtcatt  1080
cacatgtgc  tttccgatg  attaaaggt  cttatgttt  tgtgag  1126



<210> 1385
<211> 200
<212> PRT
<213> Rattus norvegicus
<308> CAA06509
<400> 1385

Cys Lys Asp Leu Gln Leu Cys His Pro Asp Phe Pro Asp Gly Glu Tyr 
  1               5                  10                  15
Trp Val Asp Pro Asn Gln Gly Cys Ser Arg Asp Ser Phe Lys Val Tyr 
             20                  25                  30
Cys Asn Phe Thr Ala Gly Gly Ser Thr Cys Val Phe Pro Asp Lys Lys 
         35                  40                  45
Ser Glu Gly Ala Arg Ile Thr Ser Trp Pro Lys Glu Asn Pro Gly Ser 
     50                  55                  60
Trp Phe Ser Glu Phe Lys Arg Gly Lys Leu Leu Ser Tyr Val Asp Ala 
 65                  70                  75                  80
Glu Gly Asn Pro Val Gly Val Val Gln Met Thr Phe Leu Arg Leu Leu 
                 85                  90                  95
Ser Ala Ser Ala Gln Gln Asn Ile Thr Tyr Asn Cys Tyr Gln Ser Val 
             100                105                110
Ala Trp Gln Asp Ala Ala Thr Gly Ser Tyr Asp Lys Ala Ile Arg Phe 
         115                120                125
Leu Gly Ser Asn Asp Glu Glu Met Ser Tyr Asp Asn Asn Pro Tyr Ile 
     130                135                140
Arg Ala Leu Val Asp Gly Cys Ala Thr Lys Lys Gly Tyr Gln Lys Thr 
 145                150                155                160
Val Leu Glu Ile Asp Thr Pro Lys Val Glu Gln Val Pro Ile Val Asp 
                 165                170                175
Ile Met Phe Thr Asp Phe Gly Glu Ala Ser Gln Lys Phe Gly Phe Glu 
             180                185                190
Val Gly Pro Pro Cys Phe Leu Gly 
         195                200



<210> 1386
<211> 2377
<212> DNA
<213> Homo sapiens
<308> BC008760
<400> 1386

ggcacgagg  tgggccccc  gggtccccc  ggcccccga  gaccctccg  agctccagg  60
gctgatggc  cacaaggtc  cccaggtgg  ataggaaac  ctggtgcag  gggagagaa  120
ggcgagcct  gcgaagcag  tgagcctgg  cttccggga  aaggcggcc  cccgggacc  180
aaaggagaa  ggggagaga  gggcgagtc  ggcccttca  gtgctgccg  accccctgg  240
cccaaaggc  ctcccggag  tgatggtcc  aaaggcagc  ctggcccag  gggttttcc  300
ggagatcct  gcccccccg  agagcctgg  cccgcgggt  aagatggtc  ccctggtga  360
aaaggagat  atggtgaac  cgggcagac  ggatccccc  gccctactg  tgaaccagg  420
ccatcgggg  ctccaggaa  aaggggtcc  ccaggcccc  caggccccg  aggcagaca  480
ggagagaaa  gggccaagg  agaagccgg  ttggaaggc  ctcctggga  gactggccc  540
atcggcccc  agggggccc  tgggaagcc  ggaccggat  gccttcgag  gatccctgg  600
cctgtggga  aacaaggtc  cccaggatc  ccaggcccg  acggtcccc  cggccccat  660
ggtccccca  gacttcccg  cctcaaagg  gattctggt  ccaaaggtg  aaagggtca  720
ccaggcctg  tcgggctca  cggtcctcc  ggtgaacag  gtgagaagg  cgaccgtgg  780
ctccctggc  cccagggct  ctccggtcc  aagggagaa  agggtatca  tggtccttc  840
ggcccgatt  ggcctcctg  gccccctgg  ctgccgggt  cgcctggtc  aaaaggtgc  900
aagggctcc  cgggtccaa  tggcccgaa  ggtgaggca  gccacccag  acccccagg  960
cccccgggc  ccccgggag  ggtcatcca  cccctgcca  tccaggcat  caggacgcg  1020
cggaacatc  acgccagcc  gctgctgga  gacgggaat  gcgagaact  cgtggacta  1080
gcggacggc  tggaagaga  cttcggctc  ctcaactct  tgaagctgg  gattgagca  1140
atgaaacgg  ccctgggca  gcagcagaa  cccgcccgc  cctgcaagg  cctgcagct  1200
tgccacccc  acttcccag  tggtgaata  tgggtcgat  ctaaccaag  atgctccag  1260
gattccttc  aggtttact  caacttcac  gccgggggg  cgacatgcg  cttccctga  1320
aagaagtcc  aaggggcca  aatcacttc  tggcccaaa  aaaacccgg  ctcctggtt  1380
agtgaattc  agcgtggga  actgctctc  tatgtggac  ccgagggca  ccctgtggg  1440
gtggtacag  tgaccttcc  gcggctgct  agcgcctct  cccaccaga  cgtcaccta  1500
cactgctac  agtcagtgg  ctggcagga  gcagccacg  gcagctacg  caaggccct  1560
cgcttcctg  gctccaacg  cgaggagat  tcctatgac  acaacccct  catccgcgc  1620
ctggtggac  gctgtgcta  caagaaagg  taccagaag  cggttctgg  gatcgacac  1680
cccaaagtg  agcaggtgc  catcgtgga  atcatgttc  atgacttcg  tgaagcgtc  1740
cagaaattt  gatttgaag  ggggccggc  tgcttcatg  gctaggagc  gccgagccc  1800
ggctcccga  agcaacctc  tgacctcag  atgccattc  ttcgtgagt  tcccgtgca  1860
gtcctgatc  tggacagtg  aggcttctc  ctcccctcc  acctgactt  atctacgcc  1920
cggcaccac  gggtgtggg  ccccagccc  gagagaaca  agggaagga  ccgcgcccc  1980
acctggagc  gaatcacat  acctagctg  accccagcg  ctgggcccg  cccacgctc  2040
gtccacacc  atgcgcccc  ggagcgggg  catgcctcc  gccccccag  tcgcccgac  2100
catcctgtt  gtgaatagg  ctcaggggt  gggggaggg  ctgccagat  tggacacta  2160
atttttttc  aaattcaac  tgaagatgt  tatttcccc  gaccttcaa  aaatgttcc  2220
aggtaagcc  cgtaaaggt  atcccacca  caccaaagc  tccgttttt  acaacctcc  2280
acacgatcc  tttagaggc  aaatgtcat  ctgcaggtg  cttcccgat  gattaaagg  2340
gcttatgtt  ttgtgaaaa  aaaaaaaaa  aaaaaaa  2377



<210> 1387
<211> 1838
<212> PRT
<213> Homo sapiens
<308> P20908
<400> 1387

Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 
  1               5                  10                  15
Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 
             20                  25                  30
Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 
         35                  40                  45
His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 
     50                  55                  60
Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 
 65                  70                  75                  80
Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 
                 85                  90                  95
Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 
             100                105                110
Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 
         115                120                125
Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 
     130                135                140
Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 
 145                150                155                160
Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 
                 165                170                175
Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 
             180                185                190
Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 
         195                200                205
Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 
     210                215                220
Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 
 225                230                235                240
Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 
                 245                250                255
Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 
             260                265                270
Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 
         275                280                285
Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 
     290                295                300
Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 
 305                310                315                320
Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 
                 325                330                335
Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 
             340                345                350
Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 
         355                360                365
Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 
     370                375                380
Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 
 385                390                395                400
Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 
                 405                410                415
Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 
             420                425                430
Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 
         435                440                445
Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 
     450                455                460
Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 
 465                470                475                480
Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 
                 485                490                495
Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 
             500                505                510
Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 
         515                520                525
Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 
     530                535                540
Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 
 545                550                555                560
Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 
                 565                570                575
Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 
             580                585                590
Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 
         595                600                605
Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 
     610                615                620
Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 
 625                630                635                640
Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 
                 645                650                655
Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 
             660                665                670
Gly Leu Pro Gly Lys Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 
         675                680                685
Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 
     690                695                700
Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 
 705                710                715                720
Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 
                 725                730                735
Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 
             740                745                750
Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 
         755                760                765
Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 
     770                775                780
Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 
 785                790                795                800
Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                 805                810                815
Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 
             820                825                830
Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 
         835                840                845
Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 
     850                855                860
Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 
 865                870                875                880
Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 
                 885                890                895
Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 
             900                905                910
Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 
         915                920                925
Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 
     930                935                940
Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 
 945                950                955                960
Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 
                 965                970                975
His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 
             980                985                990
Pro Gly Pro Pro Gly Val Val Gly Pro Gln Gly Pro Thr Gly Glu Thr 
         995                1000                1005
Gly Pro Met Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro Pro Gly 
     1010                1015                1020
Glu Gln Gly Leu Pro Gly Leu Ala Gly Lys Glu Gly Thr Lys Gly Asp 
 1025                1030                1035                1040
Pro Gly Pro Ala Gly Leu Pro Gly Lys Asp Gly Pro Pro Gly Leu Arg 
                 1045                1050                1055
Gly Phe Pro Gly Asp Arg Gly Leu Pro Gly Pro Val Gly Ala Leu Gly 
             1060                1065                1070
Leu Lys Gly Asn Glu Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Ser 
         1075                1080                1085
Pro Gly Glu Arg Gly Pro Ala Gly Ala Ala Gly Pro Ile Gly Ile Pro 
     1090                1095                1100
Gly Arg Pro Gly Pro Gln Gly Pro Pro Gly Pro Ala Gly Glu Lys Gly 
 1105                1110                1115                1120
Ala Pro Gly Glu Lys Gly Pro Gln Gly Pro Ala Gly Arg Asp Gly Leu 
                 1125                1130                1135
Gln Gly Pro Val Gly Leu Pro Gly Pro Ala Gly Pro Val Gly Pro Pro 
             1140                1145                1150
Gly Glu Asp Gly Asp Lys Gly Glu Ile Gly Glu Pro Gly Gln Lys Gly 
         1155                1160                1165
Ser Lys Gly Asp Lys Gly Glu Gln Gly Pro Pro Gly Pro Thr Gly Pro 
     1170                1175                1180
Gln Gly Pro Ile Gly Gln Pro Gly Pro Ser Gly Ala Asp Gly Glu Pro 
 1185                1190                1195                1200
Gly Pro Arg Gly Gln Gln Gly Leu Phe Gly Gln Lys Gly Asp Glu Gly 
                 1205                1210                1215
Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu 
             1220                1225                1230
Pro Gly Pro Pro Gly Glu Lys Gly Glu Thr Gly Asp Val Gly Gln Met 
         1235                1240                1245
Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Ser Gly Ala Pro Gly 
     1250                1255                1260
Ala Asp Gly Pro Gln Gly Pro Pro Gly Gly Ile Gly Asn Pro Gly Ala 
 1265                1270                1275                1280
Val Gly Glu Lys Gly Glu Pro Gly Glu Ala Gly Glu Pro Gly Pro Ser 
                 1285                1290                1295
Gly Arg Ser Gly Pro Pro Gly Pro Lys Gly Glu Arg Gly Glu Lys Gly 
             1300                1305                1310
Glu Ser Gly Pro Ser Gly Ala Ala Gly Pro Pro Gly Pro Lys Gly Pro 
         1315                1320                1325
Pro Gly Asp Asp Gly Pro Lys Gly Ser Pro Gly Pro Val Gly Phe Pro 
     1330                1335                1340
Gly Asp Pro Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly Gln Asp Gly 
 1345                1350                1355                1360
Pro Pro Gly Asp Lys Gly Asp Asp Gly Glu Pro Gly Gln Thr Gly Ser 
                 1365                1370                1375
Pro Gly Pro Thr Gly Glu Pro Gly Pro Ser Gly Pro Pro Gly Lys Arg 
             1380                1385                1390
Gly Pro Pro Gly Pro Ala Gly Pro Glu Gly Arg Gln Gly Glu Lys Gly 
         1395                1400                1405
Ala Lys Gly Glu Ala Gly Leu Glu Gly Pro Pro Gly Lys Thr Gly Pro 
     1410                1415                1420
Ile Gly Pro Gln Gly Ala Pro Gly Lys Pro Gly Pro Asp Gly Leu Arg 
 1425                1430                1435                1440
Gly Ile Pro Gly Pro Val Gly Glu Gln Gly Leu Pro Gly Ser Pro Gly 
                 1445                1450                1455
Pro Asp Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Leu Pro Gly Leu 
             1460                1465                1470
Lys Gly Asp Ser Gly Pro Lys Gly Glu Lys Gly His Pro Gly Leu Ile 
         1475                1480                1485
Gly Leu Ile Gly Pro Pro Gly Glu Gln Gly Glu Lys Gly Asp Arg Gly 
     1490                1495                1500
Leu Pro Gly Pro Gln Gly Ser Ser Gly Pro Lys Gly Glu Gln Gly Ile 
 1505                1510                1515                1520
Thr Gly Pro Ser Gly Pro Ile Gly Pro Pro Gly Pro Pro Gly Leu Pro 
                 1525                1530                1535
Gly Pro Pro Gly Pro Lys Gly Ala Lys Gly Ser Ser Gly Pro Thr Gly 
             1540                1545                1550
Pro Arg Gly Glu Ala Gly His Pro Gly Pro Pro Gly Pro Pro Gly Pro 
         1555                1560                1565
Pro Gly Glu Val Ile Gln Pro Leu Pro Ile Gln Ala Ser Arg Thr Arg 
     1570                1575                1580
Arg Asn Ile Asp Ala Ser Gln Leu Leu Asp Asp Gly Asn Gly Glu Asn 
 1585                1590                1595                1600
Tyr Val Asp Tyr Ala Asp Gly Met Glu Glu Ile Phe Gly Ser Leu Asn 
                 1605                1610                1615
Ser Leu Lys Leu Glu Ile Glu Gln Met Lys Arg Pro Leu Gly Thr Gln 
             1620                1625                1630
Gln Asn Pro Ala Arg Thr Cys Lys Asp Leu Gln Leu Cys His Pro Asp 
         1635                1640                1645
Phe Pro Asp Gly Glu Tyr Trp Val Asp Pro Asn Gln Gly Cys Ser Arg 
     1650                1655                1660
Asp Ser Phe Lys Val Tyr Cys Asn Phe Thr Ala Gly Gly Ser Thr Cys 
 1665                1670                1675                1680
Val Phe Pro Asp Lys Lys Ser Glu Gly Ala Arg Ile Thr Ser Trp Pro 
                 1685                1690                1695
Lys Glu Asn Pro Gly Ser Trp Phe Ser Glu Phe Lys Arg Gly Lys Leu 
             1700                1705                1710
Leu Ser Tyr Val Asp Ala Glu Gly Asn Pro Val Gly Val Val Gln Met 
         1715                1720                1725
Thr Phe Leu Arg Leu Leu Ser Ala Ser Ala His Gln Asn Val Thr Tyr 
     1730                1735                1740
His Cys Tyr Gln Ser Val Ala Trp Gln Asp Ala Ala Thr Gly Ser Tyr 
 1745                1750                1755                1760
Asp Lys Ala Leu Arg Phe Leu Gly Ser Asn Asp Glu Glu Met Ser Tyr 
                 1765                1770                1775
Asp Asn Asn Pro Tyr Ile Arg Ala Leu Val Asp Gly Cys Ala Thr Lys 
             1780                1785                1790
Lys Gly Tyr Gln Lys Thr Val Leu Glu Ile Asp Thr Pro Lys Val Glu 
         1795                1800                1805
Gln Val Pro Ile Val Asp Ile Met Phe Asn Asp Phe Gly Glu Ala Ser 
     1810                1815                1820
Gln Lys Phe Gly Phe Glu Val Gly Pro Ala Cys Phe Met Gly 
 1825                1830                1835



<210> 1389
<211> 484
<212> PRT
<213> Rattus norvegicus
<308> O89046
<400> 1389

Met Ser Phe Arg Lys Val Val Arg Gln Ser Lys Phe Arg His Val Phe 
  1               5                  10                  15
Gly Gln Pro Val Lys Asn Asp Gln Cys Tyr Glu Asp Ile Arg Val Ser 
             20                  25                  30
Arg Val Thr Trp Asp Ser Thr Phe Cys Ala Val Asn Pro Lys Phe Leu 
         35                  40                  45
Ala Val Ile Val Glu Ala Ser Gly Gly Gly Ala Phe Met Val Leu Pro 
     50                  55                  60
Leu Asn Lys Thr Gly Arg Ile Asp Lys Ala Tyr Pro Thr Val Cys Gly 
 65                  70                  75                  80
His Thr Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Glu 
                 85                  90                  95
Val Ile Ala Ser Gly Ser Glu Asp Cys Thr Val Met Val Trp Gln Ile 
             100                105                110
Pro Glu Asn Gly Leu Thr Ser Pro Leu Thr Glu Pro Val Val Val Leu 
         115                120                125
Glu Gly His Thr Lys Arg Val Gly Ile Ile Thr Trp His Pro Thr Ala 
     130                135                140
Arg Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Val Leu Ile Trp 
 145                150                155                160
Asn Val Gly Thr Ala Glu Glu Leu Tyr Arg Leu Asp Ser Leu His Pro 
                 165                170                175
Asp Leu Ile Tyr Asn Val Ser Trp Asn His Asn Gly Ser Leu Phe Cys 
             180                185                190
Thr Ala Cys Lys Asp Lys Ser Val Arg Ile Ile Asp Pro Arg Arg Gly 
         195                200                205
Thr Leu Val Ala Glu Arg Glu Lys Ala His Glu Gly Ala Arg Pro Met 
     210                215                220
Arg Ala Ile Phe Leu Ala Asp Gly Lys Val Phe Thr Ala Gly Phe Ser 
 225                230                235                240
Arg Met Ser Glu Arg Gln Leu Ala Leu Trp Asp Pro Glu Asn Phe Glu 
                 245                250                255
Glu Pro Met Ala Leu Gln Glu Leu Asp Ser Ser Asn Gly Ala Leu Leu 
             260                265                270
Pro Phe Tyr Asp Pro Asp Thr Ser Val Val Tyr Val Cys Gly Lys Gly 
         275                280                285
Asp Ser Ser Ile Arg Tyr Phe Glu Ile Thr Asp Glu Pro Pro Tyr Ile 
     290                295                300
His Phe Leu Asn Thr Phe Thr Ser Lys Glu Pro Gln Arg Gly Met Gly 
 305                310                315                320
Ser Met Pro Lys Arg Gly Leu Glu Val Ser Lys Cys Glu Ile Ala Arg 
                 325                330                335
Phe Tyr Lys Leu His Glu Arg Lys Cys Glu Pro Ile Val Met Thr Val 
             340                345                350
Pro Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr Pro Asp Thr Ala 
         355                360                365
Gly Pro Asp Ala Ala Leu Glu Ala Glu Asp Trp Val Ser Gly Gln Asp 
     370                375                380
Ala Asp Pro Ile Leu Ile Ser Leu Arg Glu Ala Tyr Val Pro Ser Lys 
 385                390                395                400
Gln Arg Asp Leu Lys Val Ser Arg Arg Asn Val Leu Ser Asp Ser Lys 
                 405                410                415
Pro Ala Gly Tyr Ser Arg Ser Gly Val Ser Thr Ala Thr Ala Ile Thr 
             420                425                430
Asp Ile Pro Ser Gly Asn Leu Ala Gly Ser Gly Glu Ala Gly Lys Leu 
         435                440                445
Glu Glu Val Met His Gly Leu Arg Ala Leu Arg Val Leu Val Lys Glu 
     450                455                460
Gln Gly Glu Arg Ile Ser Arg Leu Glu Glu His Leu Gly Arg Met Glu 
 465                470                475                480
Asn Gly Asp Thr 
                 485



<210> 1390
<211> 1877
<212> DNA
<213> Homo sapiens
<308> BC006449
<400> 1390

ccgggatcc  gagccgccc  aagccggtg  cgcagcccc  tgcgccccc  gtgcccccg  1860
catgtcctt  cgcaaag  1877



<210> 1391
<211> 489
<212> PRT
<213> Homo sapiens
<308> Q9BR76
<400> 1391

Met Ser Phe Arg Lys Val Val Arg Gln Ser Lys Phe Arg His Val Phe 
  1               5                  10                  15
Gly Gln Pro Val Lys Asn Asp Gln Cys Tyr Glu Asp Ile Arg Val Ser 
             20                  25                  30
Arg Val Thr Trp Asp Ser Thr Phe Cys Ala Val Asn Pro Lys Phe Leu 
         35                  40                  45
Ala Val Ile Val Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro 
     50                  55                  60
Leu Ser Lys Thr Gly Arg Ile Asp Lys Ala Tyr Pro Thr Val Cys Gly 
 65                  70                  75                  80
His Thr Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Glu 
                 85                  90                  95
Val Ile Ala Ser Gly Ser Glu Asp Cys Thr Val Met Val Trp Gln Ile 
             100                105                110
Pro Glu Asn Gly Leu Thr Ser Pro Leu Thr Glu Pro Val Val Val Leu 
         115                120                125
Glu Gly His Thr Lys Arg Val Gly Ile Ile Ala Trp His Pro Thr Ala 
     130                135                140
Arg Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Val Leu Ile Trp 
 145                150                155                160
Asn Val Gly Thr Ala Glu Glu Leu Tyr Arg Leu Asp Ser Leu His Pro 
                 165                170                175
Asp Leu Ile Tyr Asn Val Ser Trp Asn His Asn Gly Ser Leu Phe Cys 
             180                185                190
Ser Ala Cys Lys Asp Lys Ser Val Arg Ile Ile Asp Pro Arg Arg Gly 
         195                200                205
Thr Leu Val Ala Glu Arg Glu Lys Ala His Glu Gly Ala Arg Pro Met 
     210                215                220
Arg Ala Ile Phe Leu Ala Asp Gly Lys Val Phe Thr Thr Gly Phe Ser 
 225                230                235                240
Arg Met Ser Glu Arg Gln Leu Ala Leu Trp Asp Pro Glu Asn Leu Glu 
                 245                250                255
Glu Pro Met Ala Leu Gln Glu Leu Asp Ser Ser Asn Gly Ala Leu Leu 
             260                265                270
Pro Phe Tyr Asp Pro Asp Thr Ser Val Val Tyr Val Cys Gly Lys Gly 
         275                280                285
Asp Ser Ser Ile Arg Tyr Phe Glu Ile Thr Glu Glu Pro Pro Tyr Ile 
     290                295                300
His Phe Leu Asn Thr Phe Thr Ser Lys Glu Pro Gln Arg Gly Met Gly 
 305                310                315                320
Ser Met Pro Lys Arg Gly Leu Glu Val Ser Lys Cys Glu Ile Ala Arg 
                 325                330                335
Phe Tyr Lys Leu His Glu Arg Lys Cys Glu Pro Ile Val Met Thr Val 
             340                345                350
Pro Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr Pro Asp Thr Ala 
         355                360                365
Gly Pro Glu Ala Ala Leu Glu Ala Glu Glu Trp Val Ser Gly Arg Asp 
     370                375                380
Ala Asp Pro Ile Leu Ile Ser Leu Arg Glu Ala Tyr Val Pro Ser Lys 
 385                390                395                400
Gln Arg Asp Leu Lys Ile Ser Arg Arg Asn Val Leu Ser Asp Ser Arg 
                 405                410                415
Pro Ala Met Ala Pro Gly Ser Ser His Leu Gly Ala Pro Ala Ser Thr 
             420                425                430
Thr Thr Ala Ala Asp Ala Thr Pro Ser Gly Ser Leu Ala Arg Ala Gly 
         435                440                445
Glu Ala Gly Lys Leu Glu Glu Val Met Gln Glu Leu Arg Ala Leu Arg 
     450                455                460
Ala Leu Val Lys Glu Gln Gly Asp Arg Ile Cys Arg Leu Glu Glu Gln 
 465                470                475                480
Leu Gly Arg Met Glu Asn Gly Asp Ala 
                 485



<210> 1393
<211> 484
<212> PRT
<213> Rattus norvegicus
<308> O89046
<400> 1393

Met Ser Phe Arg Lys Val Val Arg Gln Ser Lys Phe Arg His Val Phe 
  1               5                  10                  15
Gly Gln Pro Val Lys Asn Asp Gln Cys Tyr Glu Asp Ile Arg Val Ser 
             20                  25                  30
Arg Val Thr Trp Asp Ser Thr Phe Cys Ala Val Asn Pro Lys Phe Leu 
         35                  40                  45
Ala Val Ile Val Glu Ala Ser Gly Gly Gly Ala Phe Met Val Leu Pro 
     50                  55                  60
Leu Asn Lys Thr Gly Arg Ile Asp Lys Ala Tyr Pro Thr Val Cys Gly 
 65                  70                  75                  80
His Thr Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Glu 
                 85                  90                  95
Val Ile Ala Ser Gly Ser Glu Asp Cys Thr Val Met Val Trp Gln Ile 
             100                105                110
Pro Glu Asn Gly Leu Thr Ser Pro Leu Thr Glu Pro Val Val Val Leu 
         115                120                125
Glu Gly His Thr Lys Arg Val Gly Ile Ile Thr Trp His Pro Thr Ala 
     130                135                140
Arg Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Val Leu Ile Trp 
 145                150                155                160
Asn Val Gly Thr Ala Glu Glu Leu Tyr Arg Leu Asp Ser Leu His Pro 
                 165                170                175
Asp Leu Ile Tyr Asn Val Ser Trp Asn His Asn Gly Ser Leu Phe Cys 
             180                185                190
Thr Ala Cys Lys Asp Lys Ser Val Arg Ile Ile Asp Pro Arg Arg Gly 
         195                200                205
Thr Leu Val Ala Glu Arg Glu Lys Ala His Glu Gly Ala Arg Pro Met 
     210                215                220
Arg Ala Ile Phe Leu Ala Asp Gly Lys Val Phe Thr Ala Gly Phe Ser 
 225                230                235                240
Arg Met Ser Glu Arg Gln Leu Ala Leu Trp Asp Pro Glu Asn Phe Glu 
                 245                250                255
Glu Pro Met Ala Leu Gln Glu Leu Asp Ser Ser Asn Gly Ala Leu Leu 
             260                265                270
Pro Phe Tyr Asp Pro Asp Thr Ser Val Val Tyr Val Cys Gly Lys Gly 
         275                280                285
Asp Ser Ser Ile Arg Tyr Phe Glu Ile Thr Asp Glu Pro Pro Tyr Ile 
     290                295                300
His Phe Leu Asn Thr Phe Thr Ser Lys Glu Pro Gln Arg Gly Met Gly 
 305                310                315                320
Ser Met Pro Lys Arg Gly Leu Glu Val Ser Lys Cys Glu Ile Ala Arg 
                 325                330                335
Phe Tyr Lys Leu His Glu Arg Lys Cys Glu Pro Ile Val Met Thr Val 
             340                345                350
Pro Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr Pro Asp Thr Ala 
         355                360                365
Gly Pro Asp Ala Ala Leu Glu Ala Glu Asp Trp Val Ser Gly Gln Asp 
     370                375                380
Ala Asp Pro Ile Leu Ile Ser Leu Arg Glu Ala Tyr Val Pro Ser Lys 
 385                390                395                400
Gln Arg Asp Leu Lys Val Ser Arg Arg Asn Val Leu Ser Asp Ser Lys 
                 405                410                415
Pro Ala Gly Tyr Ser Arg Ser Gly Val Ser Thr Ala Thr Ala Ile Thr 
             420                425                430
Asp Ile Pro Ser Gly Asn Leu Ala Gly Ser Gly Glu Ala Gly Lys Leu 
         435                440                445
Glu Glu Val Met His Gly Leu Arg Ala Leu Arg Val Leu Val Lys Glu 
     450                455                460
Gln Gly Glu Arg Ile Ser Arg Leu Glu Glu His Leu Gly Arg Met Glu 
 465                470                475                480
Asn Gly Asp Thr 
                 485



<210> 1394
<211> 1877
<212> DNA
<213> Homo sapiens
<308> BC006449
<400> 1394

ccgggatcc  gagccgccc  aagccggtg  cgcagcccc  tgcgccccc  gtgcccccg  1860
catgtcctt  cgcaaag  1877



<210> 1395
<211> 489
<212> PRT
<213> Homo sapiens
<308> Q9BR76
<400> 1395

Met Ser Phe Arg Lys Val Val Arg Gln Ser Lys Phe Arg His Val Phe 
  1               5                  10                  15
Gly Gln Pro Val Lys Asn Asp Gln Cys Tyr Glu Asp Ile Arg Val Ser 
             20                  25                  30
Arg Val Thr Trp Asp Ser Thr Phe Cys Ala Val Asn Pro Lys Phe Leu 
         35                  40                  45
Ala Val Ile Val Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro 
     50                  55                  60
Leu Ser Lys Thr Gly Arg Ile Asp Lys Ala Tyr Pro Thr Val Cys Gly 
 65                  70                  75                  80
His Thr Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Glu 
                 85                  90                  95
Val Ile Ala Ser Gly Ser Glu Asp Cys Thr Val Met Val Trp Gln Ile 
             100                105                110
Pro Glu Asn Gly Leu Thr Ser Pro Leu Thr Glu Pro Val Val Val Leu 
         115                120                125
Glu Gly His Thr Lys Arg Val Gly Ile Ile Ala Trp His Pro Thr Ala 
     130                135                140
Arg Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Val Leu Ile Trp 
 145                150                155                160
Asn Val Gly Thr Ala Glu Glu Leu Tyr Arg Leu Asp Ser Leu His Pro 
                 165                170                175
Asp Leu Ile Tyr Asn Val Ser Trp Asn His Asn Gly Ser Leu Phe Cys 
             180                185                190
Ser Ala Cys Lys Asp Lys Ser Val Arg Ile Ile Asp Pro Arg Arg Gly 
         195                200                205
Thr Leu Val Ala Glu Arg Glu Lys Ala His Glu Gly Ala Arg Pro Met 
     210                215                220
Arg Ala Ile Phe Leu Ala Asp Gly Lys Val Phe Thr Thr Gly Phe Ser 
 225                230                235                240
Arg Met Ser Glu Arg Gln Leu Ala Leu Trp Asp Pro Glu Asn Leu Glu 
                 245                250                255
Glu Pro Met Ala Leu Gln Glu Leu Asp Ser Ser Asn Gly Ala Leu Leu 
             260                265                270
Pro Phe Tyr Asp Pro Asp Thr Ser Val Val Tyr Val Cys Gly Lys Gly 
         275                280                285
Asp Ser Ser Ile Arg Tyr Phe Glu Ile Thr Glu Glu Pro Pro Tyr Ile 
     290                295                300
His Phe Leu Asn Thr Phe Thr Ser Lys Glu Pro Gln Arg Gly Met Gly 
 305                310                315                320
Ser Met Pro Lys Arg Gly Leu Glu Val Ser Lys Cys Glu Ile Ala Arg 
                 325                330                335
Phe Tyr Lys Leu His Glu Arg Lys Cys Glu Pro Ile Val Met Thr Val 
             340                345                350
Pro Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr Pro Asp Thr Ala 
         355                360                365
Gly Pro Glu Ala Ala Leu Glu Ala Glu Glu Trp Val Ser Gly Arg Asp 
     370                375                380
Ala Asp Pro Ile Leu Ile Ser Leu Arg Glu Ala Tyr Val Pro Ser Lys 
 385                390                395                400
Gln Arg Asp Leu Lys Ile Ser Arg Arg Asn Val Leu Ser Asp Ser Arg 
                 405                410                415
Pro Ala Met Ala Pro Gly Ser Ser His Leu Gly Ala Pro Ala Ser Thr 
             420                425                430
Thr Thr Ala Ala Asp Ala Thr Pro Ser Gly Ser Leu Ala Arg Ala Gly 
         435                440                445
Glu Ala Gly Lys Leu Glu Glu Val Met Gln Glu Leu Arg Ala Leu Arg 
     450                455                460
Ala Leu Val Lys Glu Gln Gly Asp Arg Ile Cys Arg Leu Glu Glu Gln 
 465                470                475                480
Leu Gly Arg Met Glu Asn Gly Asp Ala 
                 485



<210> 1396
<211> 2752
<212> DNA
<213> Rattus norvegicus
<308> AJ006710
<400> 1396

cttgtcatg  gggaggcgg  gaagttcca  tacatctac  gctgtgacc  ggacatcaa  60
gtgcagctg  agataggga  cttggaagg  aagagagaa  aaaagagct  caaagctgt  120
ctagaagat  ccatgctaa  gttttccgg  ctataccaa  agacatgct  tgatctgta  180
gtgacttgt  aagtttttg  tgaagggaa  cccttggcc  tgccagtca  aacatccta  240
aaaccattt  gtacacgat  gaattggaa  gagtggctg  aactcccgg  gaaataccc  300
gacctgccc  ggaacgccc  agtggcctt  actatatgg  atgtgtatg  acccggaag  360
gctgtgccg  tgggaggaa  aaccgtgtc  ctctttgga  aatatggca  gtttcgcca  420
ggaatgcac  acttgaaag  ctggcctaa  gtggaggca  atggctccg  acccacacg  480
accccgggc  gaacaagca  cacactctc  gaagaccag  tgagccgcc  tgccaagct  540
accaaggct  atcggcagg  acacatggt  aaggtggat  ggttggaca  actaacgtt  600
agagagata  aaatgataa  tgagagtga  aaacgaagc  ctaatttca  gtacttgat  660
gttgagttt  gctgtgtca  atgcgatga  aaggaatat  gtattgtct  ctatgaaaa  720
gatggtgac  aatcatctc  aattttaac  agctttgag  tagtgaaag  tcctgatcc  780
caaatgtct  tggagaact  agtggagag  aaacaccac  agcttgctc  gagtttaag  840
agtggacca  ctgaccacg  tctcaaacc  aacgctacc  caagagatc  gctaaatat  900
attgtgagc  acccaccaa  caagcagct  acatatgaa  aacaagatc  tgtttggaa  960
tttagatat  atcttacta  tcaagaaaa  gctctgaca  agttcttga  gtgtgttaa  1020
tgggaccta  cccaggagg  caagcaggc  ctggaactt  tgggaaagt  gaagccaat  1080
gatgtggag  attccctag  gctgctctc  tctcattac  ccaacccca  cgtgcggcg  1140
tacgctgtg  cccgcttga  gcaggccga  gacgaggat  tgctgatgt  cttgctgca  1200
ctggtccag  ctctgaaat  tgaaaactt  gatgacata  agaacggtt  ggagcctac  1260
aagaaggat  gtcaagctt  cgtgtcaga  agcctgtca  gttctggag  cagttctgc  1320
gatatagat  gctctcaaa  tataaccaa  cctcttcct  cggtggcct  ccctcctcc  1380
gcatctaaa  caaaggaag  ttctgatgg  gaaaaccta  agcaggatc  ttgtacctt  1440
ttgatatca  gagcctgta  gaactcaac  ctggctaac  atttatact  gtatgtgat  1500
gtggagtgc  aagatcagg  cacacagca  agggaccca  agactcacg  gatgtacct  1560
aacgtcatg  ggcgcttca  ccaagccct  ctcaagggt  acaagtccg  gcgggtcat  1620
cgctccctg  tggcggcac  gcagacctt  gtagatcgc  tggtgcatc  gatgaaggc  1680
gtgcagaga  aaagtggga  ccgcaagaa  aagaatgag  gacttcaag  cttgcttgg  1740
gataatgaa  aaatgaact  atcagatgt  gagctgatc  cattgccgt  agagccaca  1800
gtgaaaata  ggggaatca  cccggaaac  gccacactg  tcaagagtg  tcttatgcc  1860
gcccagctg  tcttcaaga  agaagacgg  ggcaaatac  ctgtgatct  caagcatgg  1920
gacgacttg  gtcaagatc  gcttatcct  cagatcatc  ccctcatgg  caagctgtt  1980
cggaaagaa  atctggatt  gaaattgac  ccttacaag  tgttagcca  gagtacaaa  2040
catggcttc  tgcagttca  ccagtcagt  cccgtcgcc  aagttcttg  cacggaggg  2100
agcattcag  actttttca  gaaatatgc  ccaagcgag  ctggaccca  tggcatcag  2160
gcagaggtc  tggacactt  cgttaagag  tgtgctggc  actgtgtga  cacctacat  2220
cttggggtt  gagaccggc  cctggataa  cttctgtta  caaagacag  caaactctt  2280
catatagat  tcgggtata  tctgggccg  gatcccaag  ctcttcctc  tccaatgaa  2340
ctgaataag  agatggtcg  agggatggg  ggtacccag  gtgagcagt  ccaagagtt  2400
agaaagcag  gttacacgg  cttcctcca  ctgcgaagg  attcaaatc  gattctgaa  2460
ttgttctcc  tgatggttg  tgcaaacat  ccagatatt  ctcttgaac  agataaaac  2520
gtaaaaaag  ttcaggata  gttccgtct  gacctgtca  atgaggagg  cgtgcatta  2580
atgcagagt  tgatcgacg  aagtgttca  gccctgttc  ctgcggtgg  ggagcagat  2640
cataagttt  cccagtact  gagaaaatg  aagtggatt  gacccatcg  gatgcctga  2700
ttagtaaga  aacacatga  aaaccactg  tgtgtactg  ggacattag  ga  2752



<210> 1397
<211> 887
<212> PRT
<213> Rattus norvegicus
<308> CAA07199
<400> 1397

Met Gly Glu Ala Glu Lys Phe His Tyr Ile Tyr Ser Cys Asp Leu Asp 
  1               5                  10                  15
Ile Asn Val Gln Leu Lys Ile Gly Ser Leu Glu Gly Lys Arg Glu Gln 
             20                  25                  30
Lys Ser Tyr Lys Ala Val Leu Glu Asp Pro Met Leu Lys Phe Ser Gly 
         35                  40                  45
Leu Tyr Gln Glu Thr Cys Ser Asp Leu Tyr Val Thr Cys Gln Val Phe 
     50                  55                  60
Ala Glu Gly Lys Pro Leu Ala Leu Pro Val Arg Thr Ser Tyr Lys Pro 
 65                  70                  75                  80
Phe Ser Thr Arg Trp Asn Trp Asn Glu Trp Leu Lys Leu Pro Val Lys 
                 85                  90                  95
Tyr Pro Asp Leu Pro Arg Asn Ala Gln Val Ala Leu Thr Ile Trp Asp 
             100                105                110
Val Tyr Gly Pro Gly Arg Ala Val Pro Val Gly Gly Thr Thr Val Ser 
         115                120                125
Leu Phe Gly Lys Tyr Gly Met Phe Arg Gln Gly Met His Asp Leu Lys 
     130                135                140
Val Trp Pro Asn Val Glu Ala Asp Gly Ser Glu Pro Thr Arg Thr Pro 
 145                150                155                160
Gly Arg Thr Ser Ser Thr Leu Ser Glu Asp Gln Met Ser Arg Leu Ala 
                 165                170                175
Lys Leu Thr Lys Ala His Arg Gln Gly His Met Val Lys Val Asp Trp 
             180                185                190
Leu Asp Arg Leu Thr Phe Arg Glu Ile Glu Met Ile Asn Glu Ser Glu 
         195                200                205
Lys Arg Ser Ser Asn Phe Met Tyr Leu Met Val Glu Phe Arg Cys Val 
     210                215                220
Lys Cys Asp Asp Lys Glu Tyr Gly Ile Val Tyr Tyr Glu Lys Asp Gly 
 225                230                235                240
Asp Glu Ser Ser Pro Ile Leu Thr Ser Phe Glu Leu Val Lys Val Pro 
                 245                250                255
Asp Pro Gln Met Ser Met Glu Asn Leu Val Glu Ser Lys His His Lys 
             260                265                270
Leu Ala Arg Ser Leu Arg Ser Gly Pro Ser Asp His Asp Leu Lys Pro 
         275                280                285
Asn Ala Thr Thr Arg Asp Gln Leu Asn Ile Ile Val Ser Tyr Pro Pro 
     290                295                300
Thr Lys Gln Leu Thr Tyr Glu Glu Gln Asp Leu Val Trp Lys Phe Arg 
 305                310                315                320
Tyr Tyr Leu Thr Asn Gln Glu Lys Ala Leu Thr Lys Phe Leu Lys Cys 
                 325                330                335
Val Asn Trp Asp Leu Pro Gln Glu Ala Lys Gln Ala Leu Glu Leu Leu 
             340                345                350
Gly Lys Trp Lys Pro Met Asp Val Glu Asp Ser Leu Glu Leu Leu Ser 
         355                360                365
Ser His Tyr Thr Asn Pro Thr Val Arg Arg Tyr Ala Val Ala Arg Leu 
     370                375                380
Arg Gln Ala Asp Asp Glu Asp Leu Leu Met Tyr Leu Leu Gln Leu Val 
 385                390                395                400
Gln Ala Leu Lys Tyr Glu Asn Phe Asp Asp Ile Lys Asn Gly Leu Glu 
                 405                410                415
Pro Thr Lys Lys Asp Ser Gln Ala Ser Val Ser Glu Ser Leu Ser Ser 
             420                425                430
Ser Gly Val Ser Ser Ala Asp Ile Asp Ser Ser Gln Ile Ile Thr Asn 
         435                440                445
Pro Leu Pro Pro Val Ala Ser Pro Pro Pro Ala Ser Lys Ser Lys Glu 
     450                455                460
Val Ser Asp Gly Glu Asn Leu Glu Gln Asp Leu Cys Thr Phe Leu Ile 
 465                470                475                480
Ser Arg Ala Cys Lys Asn Ser Thr Leu Ala Asn Tyr Leu Tyr Trp Tyr 
                 485                490                495
Val Ile Val Glu Cys Glu Asp Gln Asp Thr Gln Gln Arg Asp Pro Lys 
             500                505                510
Thr His Glu Met Tyr Leu Asn Val Met Arg Arg Phe Ser Gln Ala Leu 
         515                520                525
Leu Lys Gly Asp Lys Ser Val Arg Val Met Arg Ser Leu Leu Ala Ala 
     530                535                540
Gln Gln Thr Phe Val Asp Arg Leu Val His Leu Met Lys Ala Val Gln 
 545                550                555                560
Arg Glu Ser Gly Asn Arg Lys Lys Lys Asn Glu Arg Leu Gln Ala Leu 
                 565                570                575
Leu Gly Asp Asn Glu Lys Met Asn Leu Ser Asp Val Glu Leu Ile Pro 
             580                585                590
Leu Pro Leu Glu Pro Gln Val Lys Ile Arg Gly Ile Ile Pro Glu Thr 
         595                600                605
Ala Thr Leu Phe Lys Ser Ala Leu Met Pro Ala Gln Leu Phe Phe Lys 
     610                615                620
Thr Glu Asp Gly Gly Lys Tyr Pro Val Ile Phe Lys His Gly Asp Asp 
 625                630                635                640
Leu Arg Gln Asp Gln Leu Ile Leu Gln Ile Ile Ser Leu Met Asp Lys 
                 645                650                655
Leu Leu Arg Lys Glu Asn Leu Asp Leu Lys Leu Thr Pro Tyr Lys Val 
             660                665                670
Leu Ala Thr Ser Thr Lys His Gly Phe Met Gln Phe Ile Gln Ser Val 
         675                680                685
Pro Val Ala Glu Val Leu Asp Thr Glu Gly Ser Ile Gln Asn Phe Phe 
     690                695                700
Arg Lys Tyr Ala Pro Ser Glu Thr Gly Pro Asn Gly Ile Ser Ala Glu 
 705                710                715                720
Val Met Asp Thr Tyr Val Lys Ser Cys Ala Gly Tyr Cys Val Ile Thr 
                 725                730                735
Tyr Ile Leu Gly Val Gly Asp Arg His Leu Asp Asn Leu Leu Leu Thr 
             740                745                750
Lys Thr Gly Lys Leu Phe His Ile Asp Phe Gly Tyr Ile Leu Gly Arg 
         755                760                765
Asp Pro Lys Pro Leu Pro Pro Pro Met Lys Leu Asn Lys Glu Met Val 
     770                775                780
Glu Gly Met Gly Gly Thr Gln Ser Glu Gln Tyr Gln Glu Phe Arg Lys 
 785                790                795                800
Gln Cys Tyr Thr Ala Phe Leu His Leu Arg Arg Tyr Ser Asn Leu Ile 
                 805                810                815
Leu Asn Leu Phe Ser Leu Met Val Asp Ala Asn Ile Pro Asp Ile Ala 
             820                825                830
Leu Glu Pro Asp Lys Thr Val Lys Lys Val Gln Asp Lys Phe Arg Leu 
         835                840                845
Asp Leu Ser Asp Glu Glu Ala Val His Tyr Met Gln Ser Leu Ile Asp 
     850                855                860
Glu Ser Val His Ala Leu Phe Ala Ala Val Val Glu Gln Ile His Lys 
 865                870                875                880
Phe Ala Gln Tyr Trp Arg Lys 
                 885



<210> 1398
<211> 2074
<212> DNA
<213> Homo sapiens
<308> AK022653
<400> 1398

ttatattta  gcatggaga  gatttacgt  aagatcaac  tattcttca  atcatttca  60
tcatggaca  gctgttacg  aaagaaaat  tggacttga  attgacacc  tataaggtg  120
tagccacca  tacaaaaca  ggcttcatg  agtttatcc  gtcagttcc  gtggctgaa  180
ttcttgata  agagggaag  attcagaac  tttttagaa  atatgcacc  agtgagaat  240
ggccaaatg  gattagtgc  gaggtcatg  acacttacg  taaaagctg  gctggatat  300
gcgtgatca  ctatatact  ggagttgga  acaggcacc  ggataacct  ttgctaaca  360
aaacaggta  caattaatg  ctaccagta  acatacatt  tatatgtcc  tggttttta  420
ccctgaatc  atgtactaa  aagataagt  gcggcctgg  gcggtggct  acgcccgta  480
tcccagcac  ttgggaggc  aagacgggt  gatcacctg  ggttgggag  tcgagacca  540
cctgaccaa  atggagaaa  cccgtctct  ctaaacaca  aaaatttgc  gggcgtggt  600
gtacatgcc  gtaatccca  ctactcagg  ggctgaggc  ggagaatcg  ttgaacccg  660
gaggcggag  ttgcagtga  ccgagattg  accattgca  tgcagacta  gcaacaaga  720
caaaacgcc  tcttagaaa  aaaaaaaaa  aaaagatga  ttgcgtaat  gaagataaa  780
cagagagtc  taaaaattc  tttaaatgt  accttggaa  aacatttag  gaaagtcct  840
tccctttta  gaattgctt  agtagtaat  ctacagatg  tcattttgc  cacacttct  900
tactggaaa  tgcctcttt  tatggaaag  caataatgg  tacaagtag  ttagtctct  960
actgtatag  tctagttag  ttgttaaaa  gtcctttct  ttacaaagt  tgcttaatt  1020
actttaata  ctaccttta  ttatttgct  ttccccttg  agttctatg  gataatcat  1080
ctcagtccc  tttgtcctg  caactcttt  gccctatgt  tttatcttt  tgcagacag  1140
ttccagact  acagctttt  acctcagtc  atttcatta  cttcaaatt  aaatatcga  1200
ctgcttact  gaaattgtc  ttatatatg  ccagttgta  aaggttgtc  tttcctcta  1260
tacctgcct  aaacctgtt  ctcacctca  ttttccatt  caatagata  caacatcac  1320
tacccagtt  ttcaagctc  agacctcaa  gtcattctt  acatgtctc  tggcctcat  1380
tcatatact  aacctatta  caaatcttg  ctactcctc  actccaaaa  agatcatga  1440
gttacccac  gtcttcatt  ttactactt  gaccccact  gaagcaaac  atatatgtt  1500
cctaaacaa  ttgaatgaa  cctgaaccc  ttattgggg  cttgtggct  gtccaggca  1560
gccatttgt  tgaatgtca  accactcct  cctcagaca  gagcctttg  tgttttctc  1620
ttctggaaa  ttatttatt  agatctttg  agggctgac  ttagttatt  agttgaagt  1680
ctaatggca  ctctttaga  aagcccttt  taactcctt  atctgtaat  acatatctg  1740
cctcttcct  caatgctct  tacttatta  tgtattgtt  atagcactt  tcactagct  1800
aagttacct  ttttgttta  ttcaacaac  atttattga  cagctagta  atgctggga  1860
taccaaagt  aacagaaga  acagaaatc  ttgctctcc  agagcttgt  gagttctta  1920
catcatctt  tccccttca  gatgcaagt  ccatgagag  aggaacctt  gtccattgg  1980
gttaccccc  tgcctctgg  ccttgaaca  cacctagct  aagtgttca  taaatcagt  2040
ttgaattaa  gatgaataa  tacttctgc  cttc  2074



<210> 1399
<211> 887
<212> PRT
<213> Homo sapiens
<308> NP_002638
<400> 1399

Met Gly Glu Ala Glu Lys Phe His Tyr Ile Tyr Ser Cys Asp Leu Asp 
  1               5                  10                  15
Ile Asn Val Gln Leu Lys Ile Gly Ser Leu Glu Gly Lys Arg Glu Gln 
             20                  25                  30
Lys Ser Tyr Asn Ala Val Leu Glu Asp Pro Met Leu Lys Phe Ser Gly 
         35                  40                  45
Leu Tyr Gln Glu Thr Cys Ser Asp Leu Tyr Val Thr Cys Gln Val Phe 
     50                  55                  60
Ala Glu Gly Lys Pro Ser Ala Leu Pro Val Arg Thr Ser Tyr Lys Ala 
 65                  70                  75                  80
Phe Ser Thr Arg Trp Asn Trp Asn Glu Trp Leu Lys Leu Pro Val Lys 
                 85                  90                  95
Tyr Pro Asp Leu Pro Arg Asn Ala Gln Val Ala Leu Thr Ile Trp Asp 
             100                105                110
Val Tyr Gly Pro Gly Lys Ala Val Pro Val Gly Gly Thr Thr Val Ser 
         115                120                125
Leu Phe Gly Lys Tyr Gly Met Ser Arg Gln Gly Met His Asp Leu Lys 
     130                135                140
Val Trp Pro Asn Val Glu Ala Asp Gly Ser Glu Pro Thr Asn Thr Pro 
 145                150                155                160
Gly Arg Thr Ser Ser Thr Leu Ser Glu Asp Gln Met Ser Arg Leu Ala 
                 165                170                175
Lys Leu Thr Lys Ala His Arg Gln Gly His Met Val Lys Val Asp Trp 
             180                185                190
Leu Asp Arg Leu Thr Phe Arg Glu Ile Glu Met Ile Asn Glu Ser Val 
         195                200                205
Lys Arg Ser Ser Asn Phe Met Tyr Leu Met Gly Gly Phe Arg Cys Val 
     210                215                220
Lys Cys Asp Asp Lys Glu Tyr Gly Ile Val Tyr Tyr Glu Lys Asp Gly 
 225                230                235                240
Asp Glu Ser Ser Pro Ile Leu Thr Ser Phe Glu Leu Val Lys Val Pro 
                 245                250                255
Asp Pro Gln Met Ser Leu Glu Asn Leu Val Glu Ser Lys His His Asn 
             260                265                270
Leu Pro Arg Ser Leu Arg Ser Gly Pro Ser Asp His Asp Leu Lys Pro 
         275                280                285
Tyr Pro Ser Pro Arg Asp Gln Leu Lys Asn Ile Val Ser Tyr Pro Pro 
     290                295                300
Ser Lys Pro Pro Thr Tyr Glu Glu Gln Asp Leu Val Trp Glu Phe Arg 
 305                310                315                320
Tyr Tyr Leu Thr Asn Gln Asp Lys Ala Leu Thr Lys Ile Leu Thr Ser 
                 325                330                335
Val Ile Trp Asp Leu Pro Gln Gly Ala Lys Gln Ala Leu Ala Leu Leu 
             340                345                350
Gly Lys Trp Asn Pro Met Asp Val Glu Asp Ser Leu Glu Leu Ile Ser 
         355                360                365
Ser His Tyr Thr Asn Pro Thr Val Arg Arg Tyr Ala Val Ala Arg Leu 
     370                375                380
Arg Gln Ala Asp Asp Glu Asp Leu Leu Met Tyr Leu Ser Gln Leu Val 
 385                390                395                400
Gln Ala Leu Lys Tyr Glu Asn Phe Asp Asp Ile Lys Asn Gly Leu Glu 
                 405                410                415
Pro Thr Lys Lys Asp Ser Gln Ser Ser Val Ser Gly Asn Val Ser Asn 
             420                425                430
Ser Gly Ile Asn Ser Ala Glu Ile Asp Ser Ser Gln Ile Ile Thr Ser 
         435                440                445
Pro Leu Pro Ser Val Ser Ser Pro Pro Pro Ala Ser Lys Thr Lys Glu 
     450                455                460
Val Pro Asp Gly Glu Asn Leu Glu Gln Asp Leu Cys Thr Phe Leu Ile 
 465                470                475                480
Ser Arg Ala Ser Lys Asn Ser Thr Leu Ala Asn Tyr Leu Tyr Trp Tyr 
                 485                490                495
Val Ile Val Glu Cys Glu Asp Gln Asp Thr Gln Gln Arg Asp Pro Lys 
             500                505                510
Thr His Glu Met Tyr Leu Asn Val Met Arg Arg Phe Ser Gln Ala Leu 
         515                520                525
Leu Lys Gly Asp Lys Ser Val Arg Val Met Arg Ser Leu Leu Ala Ala 
     530                535                540
Gln Gln Thr Phe Val Asp Arg Leu Val His Leu Met Lys Ala Val Gln 
 545                550                555                560
Arg Glu Ser Gly Asn Arg Lys Lys Lys Asn Glu Arg Leu Gln Ala Leu 
                 565                570                575
Leu Gly Asp Asn Glu Lys Met Asn Leu Ser Asp Val Glu Leu Ile Pro 
             580                585                590
Leu Pro Leu Glu Pro Gln Val Lys Ile Arg Gly Ile Ile Pro Glu Thr 
         595                600                605
Ala Thr Leu Phe Lys Ser Ala Leu Met Pro Ala Gln Leu Phe Phe Lys 
     610                615                620
Thr Glu Asp Gly Gly Lys Tyr Pro Val Ile Phe Lys His Gly Asp Asp 
 625                630                635                640
Leu Arg Gln Asp Gln Leu Ile Leu Gln Ile Ile Ser Leu Met Asp Lys 
                 645                650                655
Leu Leu Arg Lys Glu Asn Leu Asp Leu Lys Leu Thr Pro Tyr Lys Val 
             660                665                670
Leu Ala Thr Ser Thr Lys His Gly Phe Met Gln Phe Ile Gln Ser Val 
         675                680                685
Pro Val Ala Glu Val Leu Asp Thr Glu Gly Ser Ile Gln Asn Phe Phe 
     690                695                700
Arg Lys Tyr Ala Pro Ser Glu Asn Gly Pro Asn Gly Ile Ser Ala Glu 
 705                710                715                720
Val Met Asp Thr Tyr Val Lys Ser Cys Ala Gly Tyr Cys Val Ile Thr 
                 725                730                735
Tyr Ile Leu Gly Val Gly Asp Arg His Leu Asp Asn Leu Val Leu Thr 
             740                745                750
Lys Thr Gly Lys Leu Phe His Ile Asp Phe Gly Tyr Ile Leu Gly Arg 
         755                760                765
Asp Pro Lys Pro Leu Pro Pro Pro Met Lys Leu Asn Lys Glu Met Val 
     770                775                780
Glu Gly Met Gly Gly Thr Gln Ser Glu Gln Tyr Gln Glu Phe Arg Lys 
 785                790                795                800
Gln Cys Tyr Thr Ala Phe Leu His Leu Arg Arg Tyr Ser Asn Leu Ile 
                 805                810                815
Leu Asn Leu Phe Ser Leu Met Val Asp Pro Asn Ile Pro Asp Ile Ala 
             820                825                830
Leu Glu Pro Asp Lys Thr Val Lys Lys Val Gln Asp Lys Phe Arg Leu 
         835                840                845
Asp Leu Ser Asp Glu Glu Ala Val His Tyr Met Gln Ser Leu Ile Asp 
     850                855                860
Glu Ser Val His Ala Leu Phe Ala Ala Val Val Glu Gln Ile His Lys 
 865                870                875                880
Phe Ala Gln Tyr Trp Arg Lys 
                 885



<210> 1400
<211> 4749
<212> DNA
<213> Rattus norvegicus
<308> AJ006855
<400> 1400

gaattcggc  cgaggccat  tagtaaaac  tcagcatgt  gacggcagg  gtgctaact  60
tttcctatt  ttatggtta  tttgtgcct  aaaatggtg  cggtgtaaa  ttggaagtg  120
aagggcatg  agttttctt  ctgtctgtt  cagccagtt  gtttatact  tattcctgg  180
gtaatctag  tgtgtaact  tcgaattgt  acaggtgcc  gagtggtac  gttcggaca  240
actgcctgg  ctgtctgga  agaacaaac  gtgtgcagg  gttccttgg  ttagagatg  300
tagctaaac  gctggaagc  ctgggcttg  ctgaaaagc  tcagttggt  actcgcttt  360
aagaagttt  ccggtccat  tggtctgtg  atggcgatt  aatcagtaa  atatatgca  420
gcaccggag  cctggaagg  aaggccaag  taaaagatg  tgcgcgatc  gtcaccaga  480
ccattcaga  taacttctt  gacagctcc  agcaagaag  cattgatgt  ctgcttctg  540
gaaacactc  gaacagcga  ttagccgac  aagcccggg  acttctaac  actgggagt  600
tgcgtgtgt  tgaacagac  ttacagtca  catcttcca  agtcttaaa  aacatgtgt  660
agaacttct  caagtactc  aagcccaag  agatccgag  gtgtgttgg  acctggaat  720
tgaacggcg  gaaacagtt  cgcagcata  cattcaaga  ccagaccct  accgactgg  780
ttcttgatg  acccaagtt  gctggcatc  aggagtttc  agataagag  agtaagcca  840
ctgatatat  tgcaattgg  tttgaagaa  tggtggagc  gaatgctgg  aacattgtg  900
atgcaagca  aacaaacca  aagctgtgg  cagtggaac  gcagaagac  atctccaga  960
acaacaagt  tgttctcct  gcctcggag  agttggtgg  tgtctgcct  tttgtcttt  1020
tcagaccgc  gcatgctcc  tttatcagg  atgttgcag  cgatactgt  aaaactggg  1080
tgggaggcg  gactggaaa  aagggcgct  ttgcaatcc  gatgctctt  cacaccacc  1140
gcctttgct  tgtctgcag  cactttgct  caggccagt  ccaagtcaa  gagagaaat  1200
aagatttcg  agaaatagc  cgaaaattg  gtttcccca  gggaagaat  ctcttctcc  1260
atgattacg  attctggtg  ggtgatttc  actatcgaa  cgatcttcc  aatgaagaa  1320
ttaaagagc  cataagaca  caaaattgg  attctctta  agctggaga  caactcatc  1380
atcagaaaa  tgcaggaca  atctttaga  gatttttag  gggaaaagt  acgtttgct  1440
caacctata  atatgactt  ttttccgaa  actatgaca  cagtgaaaa  tgccgcacc  1500
ctgcttgga  agaccgagt  ctctggaga  ggaggaagt  gccttttga  agatcagct  1560
aagacttag  tcttctgaa  gctagtttc  aagatgaaa  taaaatcct  tatacatgg  1620
ctcctggca  cttgctgca  tatggaaga  ccgagctga  gacttctga  cacaggccc  1680
ttgtcgccc  gatcgatat  gatatattt  aagttgaag  tgaagagag  caaaaaatt  1740
ataaagaag  tattgcagt  cagggccca  cggacggca  agtactggt  tcaatcaaa  1800
gttctgcac  agagaatac  ttctttgac  atgctttga  cgatgagct  ctgcagcag  1860
ttgcacact  cggcgaagt  atacttata  gattcgtag  agataaaat  tgggttaca  1920
ttttggagg  gagctctgc  ttgaatgtt  tgagcctaa  tggtaaaga  ttattaaat  1980
ggactataa  aattacttt  aaaagtcca  actggatca  aactttgga  gaagagatg  2040
gtttagaga  aatcagtgt  acattgccc  catcaacca  ttccaccct  ctcggtgaa  2100
atgcagagg  ctcagcgga  tttgacatg  aaggtgatg  cgacgacta  agtgctgag  2160
tggaggagc  tcttcctca  cacctccag  catcctcca  ctctggcct  ggcacctct  2220
caagctctt  gccccggac  agtccctgc  agtcaccca  agcaccaga  tactccgca  2280
cttctcttc  catcagacc  agtcgagca  catcaagaa  tccaggacc  ctaagttca  2340
agggtgctc  agttgacac  cagccagca  cccagaagg  gtcttccca  accatagag  2400
ccaagaggc  accccctcc  cgcccagtt  ctcctccag  acgtcctgc  ccaccacag  2460
ggccacctc  accttcagg  gctaggagt  cggcacctg  tagaaaaga  tttggaggt  2520
tcggagccc  tcccagtcc  ggggttact  ggagagaga  ggaagcacc  aaaagcccg  2580
gaacagcac  gaaagataa  atagggcgt  atcagcctt  ccctcaagc  ggacttgca  2640
gcccaggac  ttctggata  ggtgcagct  gaccgacaa  tccagctcg  gctggagtg  2700
tcagtgccc  tcagagcca  gctcgggtg  ctgctggaa  gctgactcc  gaaagccaa  2760
gcaaaccct  ggagacatc  aaaggtcct  ctgtccttc  agaaccact  aagcctcag  2820
ctgcatttc  tccgcagcc  tctctgccc  cacctgctc  aaagttaca  gacccactt  2880
tccccatag  agcacctat  cctccctcc  ttccccaat  gaatttgga  actccaccc  2940
tgcccccac  tcggagcag  tcatctcaa  gcttgcctt  agactcctc  ccacagcta  3000
aacaggagc  accaacagg  taacagcag  taaaaataa  tggagcttg  ggtgtcaaa  3060
aagagccaa  attgaagag  gacccattt  aagacctct  acttagtgt  cttgctgta  3120
ccaaggctc  gccttctgc  cagatttca  ctgttctaa  cccagaccc  aagatgttg  3180
ttcagttgc  ttctgcatc  caaagtaaa  ttaactctt  gagttctgt  agttgcatg  3240
taaccatgc  tccagttcc  gagcaaagc  agtcacagg  aagtgtggg  agttctgca  3300
acccatttc  cagcctgcc  accaggaac  cttttacag  caggactgc  gcccctgga  3360
acccattta  agttcagtc  caagaatca  aggcaactt  ttggctatc  aaagaagag  3420
ctgtttcta  cagtccttt  cctcctctc  tgcctctca  tcacgacat  agcaagcct  3480
caagttcac  agatggttt  gaggacaat  ttgatctgc  gagccagtc  acagtaaaa  3540
caagcaacc  caaaggatg  gtaacattt  acgaagatg  agactttcc  acaaaagga  3600
agtcaaggt  ggtttatcc  gactccctg  gtaatacag  agcttcatt  gatgatgac  3660
ggagtaaag  tacaaacgt  tctttctgt  tgctgccag  cagaaggcc  ccacctcca  3720
cacctcctg  ccctctgct  ccacctggc  ccacctcat  tgcaggacc  agcacaacc  3780
tgtcatcta  ggcatctcc  acattggac  tcacagaaa  ataatgaca  ggagggaag  3840
gagtttctc  tggtgtggt  tgactgttt  tttctgttt  tcagggtag  cccaagaga  3900
tggggcatt  attagttgt  atgtgcaat  aataatcag  aagtgcact  atatctata  3960
aaaatacca  tagaggatg  ggacaaagc  ggagtttgt  tatatcaga  atagcaaag  4020
catcctctt  actggagtt  tggcctttc  cttcagatg  atggaagag  ataggaacc  4080
tttttaaaa  tgcttaaaa  tactctaga  tagtcctta  tcagatact  acatagcaa  4140
cacgtaaag  ccacacaac  gcagctgac  gtactgcca  cccattgtg  tgttgacga  4200
tggtattcg  ggatactta  caaagagct  ccagagttc  ggtgagatt  ctttgaacg  4260
cattacttt  gccaaaagg  ctgtgtata  atacactgt  tgtgtatgt  tgtatgtat  4320
cacaaacac  catgtgtac  tccacatac  tataaaatc  gtcttgata  aattcagat  4380
aaattttac  taacagttc  gacaatgtc  tttttttca  tatctcact  tcaagaagc  4440
ggctgccac  gggtgtgct  cattacgtc  ctaactgcc  cccagaatg  aagggtcag  4500
ccctttaca  agctgccat  tcctgttac  ctgcacctc  gaccttcac  ttcatccta  4560
taccttcct  ctctggtat  cctttccct  ggcatttac  atgggcagt  cagacgtgg  4620
cagtcatgt  acagatact  aaaacagta  gcacctgcc  ccagattcc  ggaggaaca  4680
tatcagtgt  ctcctttct  tgcacagcc  tttcccttc  gacctttct  tttgcctcg  4740
gccgaattc  4749



<210> 1401
<211> 1574
<212> PRT
<213> Rattus norvegicus
<308> Q62910
<400> 1401

Met Ala Phe Ser Lys Gly Phe Arg Ile Tyr His Lys Leu Asp Pro Pro 
  1               5                  10                  15
Pro Phe Ser Leu Ile Val Glu Thr Arg His Lys Glu Glu Cys Leu Met 
             20                  25                  30
Phe Glu Ser Gly Ala Val Ala Val Leu Ser Ser Ala Glu Lys Glu Ala 
         35                  40                  45
Ile Lys Gly Thr Tyr Ala Lys Val Leu Asp Ala Tyr Gly Leu Leu Gly 
     50                  55                  60
Val Leu Arg Leu Asn Leu Gly Asp Thr Met Leu His Tyr Leu Val Leu 
 65                  70                  75                  80
Val Thr Gly Cys Met Ser Val Gly Lys Ile Gln Glu Ser Glu Val Phe 
                 85                  90                  95
Arg Val Thr Ser Thr Glu Phe Ile Ser Leu Arg Val Asp Ala Ser Asp 
             100                105                110
Glu Asp Arg Ile Ser Glu Val Arg Lys Val Leu Asn Ser Gly Asn Phe 
         115                120                125
Tyr Phe Ala Trp Ser Ala Ser Gly Val Ser Leu Asp Leu Ser Leu Asn 
     130                135                140
Ala His Arg Ser Met Gln Glu His Thr Thr Asp Asn Arg Phe Phe Trp 
 145                150                155                160
Asn Gln Ser Leu His Leu His Leu Lys His Tyr Gly Val Asn Cys Asp 
                 165                170                175
Asp Trp Leu Leu Arg Leu Met Cys Gly Gly Val Glu Ile Arg Thr Ile 
             180                185                190
Tyr Ala Ala His Lys Gln Ala Lys Ala Cys Leu Ile Ser Arg Leu Ser 
         195                200                205
Cys Glu Arg Ala Gly Thr Arg Phe Asn Val Arg Gly Thr Asn Asp Asp 
     210                215                220
Gly His Val Ala Asn Phe Val Glu Thr Glu Gln Val Ile Tyr Leu Asp 
 225                230                235                240
Asp Cys Val Ser Ser Phe Ile Gln Ile Arg Gly Ser Val Pro Leu Phe 
                 245                250                255
Trp Glu Gln Pro Gly Leu Gln Val Gly Ser His Arg Val Arg Met Ser 
             260                265                270
Arg Gly Phe Glu Ala Asn Ala Pro Ala Phe Asp Arg His Phe Arg Thr 
         275                280                285
Leu Lys Asp Leu Tyr Gly Lys Gln Ile Val Val Asn Leu Leu Gly Ser 
     290                295                300
Lys Glu Gly Glu His Met Leu Ser Lys Ala Phe Gln Ser His Leu Lys 
 305                310                315                320
Ala Ser Glu His Ala Ser Asp Ile His Met Val Ser Phe Asp Tyr His 
                 325                330                335
Gln Met Val Lys Gly Gly Lys Ala Glu Lys Leu His Ser Val Leu Lys 
             340                345                350
Pro Gln Val Gln Lys Phe Leu Asp Tyr Gly Phe Phe Tyr Phe Asp Gly 
         355                360                365
Ser Ala Val Gln Arg Cys Gln Ser Gly Thr Val Arg Thr Asn Cys Leu 
     370                375                380
Asp Cys Leu Asp Arg Thr Asn Ser Val Gln Ala Phe Leu Gly Leu Glu 
 385                390                395                400
Met Leu Ala Lys Gln Leu Glu Ala Leu Gly Leu Ala Glu Lys Pro Gln 
                 405                410                415
Leu Val Thr Arg Phe Gln Glu Val Phe Arg Ser Met Trp Ser Val Asn 
             420                425                430
Gly Asp Ser Ile Ser Lys Ile Tyr Ala Gly Thr Gly Ala Leu Glu Gly 
         435                440                445
Lys Ala Lys Leu Lys Asp Gly Ala Arg Ser Val Thr Arg Thr Ile Gln 
     450                455                460
Asn Asn Phe Phe Asp Ser Ser Lys Gln Glu Ala Ile Asp Val Leu Leu 
 465                470                475                480
Leu Gly Asn Thr Leu Asn Ser Asp Leu Ala Asp Lys Ala Arg Ala Leu 
                 485                490                495
Leu Thr Thr Gly Ser Leu Arg Val Ser Glu Gln Thr Leu Gln Ser Ala 
             500                505                510
Ser Ser Lys Val Leu Lys Asn Met Cys Glu Asn Phe Tyr Lys Tyr Ser 
         515                520                525
Lys Pro Lys Lys Ile Arg Val Cys Val Gly Thr Trp Asn Val Asn Gly 
     530                535                540
Gly Lys Gln Phe Arg Ser Ile Ala Phe Lys Asn Gln Thr Leu Thr Asp 
 545                550                555                560
Trp Leu Leu Asp Ala Pro Lys Leu Ala Gly Ile Gln Glu Phe Gln Asp 
                 565                570                575
Lys Arg Ser Lys Pro Thr Asp Ile Phe Ala Ile Gly Phe Glu Glu Met 
             580                585                590
Val Glu Leu Asn Ala Gly Asn Ile Val Asn Ala Ser Thr Thr Asn Gln 
         595                600                605
Lys Leu Trp Ala Val Glu Leu Gln Lys Thr Ile Ser Arg Asp Asn Lys 
     610                615                620
Tyr Val Leu Leu Ala Ser Glu Gln Leu Val Gly Val Cys Leu Phe Val 
 625                630                635                640
Phe Ile Arg Pro Gln His Ala Pro Phe Ile Arg Asp Val Ala Val Asp 
                 645                650                655
Thr Val Lys Thr Gly Met Gly Gly Ala Thr Gly Asn Lys Gly Ala Val 
             660                665                670
Ala Ile Arg Met Leu Phe His Thr Thr Ser Leu Cys Phe Val Cys Ser 
         675                680                685
His Phe Ala Ala Gly Gln Ser Gln Val Lys Glu Arg Asn Glu Asp Phe 
     690                695                700
Val Glu Ile Ala Arg Lys Leu Ser Phe Pro Met Gly Arg Met Leu Phe 
 705                710                715                720
Ser His Asp Tyr Val Phe Trp Cys Gly Asp Phe Asn Tyr Arg Ile Asp 
                 725                730                735
Leu Pro Asn Glu Glu Val Lys Glu Leu Ile Arg Gln Gln Asn Trp Asp 
             740                745                750
Ser Leu Ile Ala Gly Asp Gln Leu Ile Asn Gln Lys Asn Ala Gly Gln 
         755                760                765
Ile Phe Arg Gly Phe Leu Glu Gly Lys Val Thr Phe Ala Pro Thr Tyr 
     770                775                780
Lys Tyr Asp Leu Phe Ser Glu Asp Tyr Asp Thr Ser Glu Lys Cys Arg 
 785                790                795                800
Thr Pro Ala Trp Thr Asp Arg Val Leu Trp Arg Arg Arg Lys Trp Pro 
                 805                810                815
Phe Asp Arg Ser Ala Glu Asp Leu Asp Leu Leu Asn Ala Ser Phe Gln 
             820                825                830
Asp Glu Ser Lys Ile Leu Tyr Thr Trp Thr Pro Gly Thr Leu Leu His 
         835                840                845
Tyr Gly Arg Ala Glu Leu Lys Thr Ser Asp His Arg Pro Val Val Ala 
     850                855                860
Leu Ile Asp Ile Asp Ile Phe Glu Val Glu Ala Glu Glu Arg Gln Lys 
 865                870                875                880
Ile Tyr Lys Glu Val Ile Ala Val Gln Gly Pro Pro Asp Gly Thr Val 
                 885                890                895
Leu Val Ser Ile Lys Ser Ser Ala Gln Glu Asn Thr Phe Phe Asp Asp 
             900                905                910
Ala Leu Ile Asp Glu Leu Leu Gln Gln Phe Ala His Phe Gly Glu Val 
         915                920                925
Ile Leu Ile Arg Phe Val Glu Asp Lys Met Trp Val Thr Phe Leu Glu 
     930                935                940
Gly Ser Ser Ala Leu Asn Val Leu Ser Leu Asn Gly Lys Glu Leu Leu 
 945                950                955                960
Asn Arg Thr Ile Thr Ile Thr Leu Lys Ser Pro Asp Trp Ile Lys Thr 
                 965                970                975
Leu Glu Glu Glu Met Ser Leu Glu Lys Ile Ser Val Thr Leu Pro Ser 
             980                985                990
Ser Thr Ser Ser Thr Leu Leu Gly Glu Asp Ala Glu Val Ser Ala Asp 
         995                1000                1005
Phe Asp Met Glu Gly Asp Val Asp Asp Tyr Ser Ala Glu Val Glu Glu 
     1010                1015                1020
Leu Leu Pro Gln His Leu Gln Pro Ser Ser Ser Ser Gly Leu Gly Thr 
 1025                1030                1035                1040
Ser Pro Ser Ser Ser Pro Arg Thr Ser Pro Cys Gln Ser Pro Thr Ala 
                 1045                1050                1055
Pro Glu Tyr Ser Ala Pro Ser Leu Pro Ile Arg Pro Ser Arg Ala Pro 
             1060                1065                1070
Ser Arg Thr Pro Gly Pro Leu Ser Ser Gln Gly Ala Pro Val Asp Thr 
         1075                1080                1085
Gln Pro Ala Ala Gln Lys Glu Ser Ser Gln Thr Ile Glu Pro Lys Arg 
     1090                1095                1100
Pro Pro Pro Pro Arg Pro Val Ala Pro Pro Ala Arg Pro Ala Pro Pro 
 1105                1110                1115                1120
Gln Arg Pro Pro Pro Pro Ser Gly Ala Arg Ser Pro Ala Pro Ala Arg 
                 1125                1130                1135
Lys Glu Phe Gly Val Gly Ala Pro Pro Ser Pro Gly Val Thr Arg Arg 
             1140                1145                1150
Glu Met Glu Gly Ala Pro Lys Ser Pro Gly Thr Ala Arg Lys Asp Asn 
         1155                1160                1165
Ile Gly Arg Asn Gln Pro Ser Pro Gln Ala Gly Leu Ala Gly Pro Gly 
     1170                1175                1180
Pro Ser Gly Tyr Gly Ala Ala Arg Pro Thr Ile Pro Ala Arg Ala Gly 
 1185                1190                1195                1200
Val Ile Ser Ala Pro Gln Ser Gln Ala Arg Val Ser Ala Gly Arg Leu 
                 1205                1210                1215
Thr Pro Glu Ser Gln Ser Lys Pro Leu Glu Thr Ser Lys Gly Pro Ala 
             1220                1225                1230
Val Leu Pro Glu Pro Leu Lys Pro Gln Ala Ala Phe Pro Pro Gln Pro 
         1235                1240                1245
Ser Leu Pro Thr Pro Ala Gln Lys Leu Gln Asp Pro Leu Val Pro Ile 
     1250                1255                1260
Ala Ala Pro Met Pro Pro Ser Ile Pro Gln Ser Asn Leu Glu Thr Pro 
 1265                1270                1275                1280
Pro Leu Pro Pro Pro Arg Ser Arg Ser Ser Gln Ser Leu Pro Ser Asp 
                 1285                1290                1295
Ser Ser Pro Gln Leu Gln Gln Glu Gln Pro Thr Gly Gln Gln Val Lys 
             1300                1305                1310
Ile Asn Gly Ala Cys Gly Val Lys Gln Glu Pro Thr Leu Lys Ser Asp 
         1315                1320                1325
Pro Phe Glu Asp Leu Ser Leu Ser Val Leu Ala Val Ser Lys Ala Gln 
     1330                1335                1340
Pro Ser Ala Gln Ile Ser Pro Val Leu Thr Pro Asp Pro Lys Met Leu 
 1345                1350                1355                1360
Ile Gln Leu Pro Ser Ala Ser Gln Ser Lys Val Asn Ser Leu Ser Ser 
                 1365                1370                1375
Val Ser Cys Met Leu Thr Met Pro Pro Val Pro Glu Gln Ser Lys Ser 
             1380                1385                1390
Gln Glu Ser Val Gly Ser Ser Ala Asn Pro Phe Pro Ser Leu Pro Thr 
         1395                1400                1405
Arg Asn Pro Phe Thr Asp Arg Thr Ala Ala Pro Gly Asn Pro Phe Arg 
     1410                1415                1420
Val Gln Ser Gln Glu Ser Glu Ala Thr Ser Trp Leu Ser Lys Glu Glu 
 1425                1430                1435                1440
Pro Val Ser Asn Ser Pro Phe Pro Pro Leu Met Pro Leu Ser His Asp 
                 1445                1450                1455
Met Ser Lys Pro Ser Ser Ser Leu Asp Gly Phe Glu Asp Asn Phe Asp 
             1460                1465                1470
Leu Gln Ser Gln Ser Thr Val Lys Thr Ser Asn Pro Lys Gly Trp Val 
         1475                1480                1485
Thr Phe Asp Glu Asp Glu Asp Phe Pro Thr Lys Gly Lys Ser Arg Ser 
     1490                1495                1500
Val Tyr Pro Asp Ser Leu Gly Asn Thr Ala Ala Ser Phe Asp Asp Asp 
 1505                1510                1515                1520
Trp Ser Lys Gly Thr Asn Val Ser Phe Cys Val Leu Pro Ala Arg Arg 
                 1525                1530                1535
Pro Pro Pro Pro Pro Pro Pro Val Pro Leu Leu Pro Pro Gly Thr Thr 
             1540                1545                1550
Ser Ser Ala Gly Pro Ser Thr Thr Leu Ser Ser Lys Ala Ser Pro Thr 
         1555                1560                1565
Leu Asp Phe Thr Glu Arg 
     1570



<210> 1402
<211> 4805
<212> DNA
<213> Homo sapiens
<308> AF009039
<400> 1402

gaggaggag  cggaggaag  gggctgcct  cgaagaaag  agaatggcg  tcagtaaag  60
attccggat  tatcacaaa  tggatcccc  acctttcag  ctcatagtg  aaactaggc  120
taaggaaga  tgtctcatg  tcgagtctg  ggctgtcgc  gtgctctca  ctgcagaaa  180
agaggcaat  aagggtaca  actccaaag  actggatgc  tatggactc  taggtgttc  240
gcggttaaa  cttggtgat  ctatgttac  ttatctggt  ctagtcact  gatgtatgt  300
tgttggaaa  attcaagaa  ctgaagttt  ccgagttac  tccactgag  ttatatcac  360
gcgaatcga  tcttcagat  aggatcgca  ttcagaagt  cggaaagtt  tgaattcag  420
aaactttta  tttgcatgg  ctgcatctg  catcagttt  gatttgagt  ttaatgcgc  480
tcgtagcat  caagaacag  caactgata  tagattttt  tggaatcag  ctttgcatt  540
gcatctcaa  cactatggc  tgaattgtg  tgactggtt  ttacgtctt  tgtgtggag  600
agtagaaat  agaacaatt  atgctgctc  taaacaggc  aaggcttgc  tcatttcaa  660
attaagctg  gaacgagct  ggaccaggt  taatgtccg  ggaacaaat  atgatggtc  720
tgttgccaa  tttgtagaa  cagaacagg  tgtgtactt  gatgactca  tttcttcct  780
catacaaat  cgaggatct  ttccattgt  ctgggagca  ccagggttg  aagtgggat  840
tcatcgtgt  cgtatgtca  ggggatttg  agccaatgc  cctgctttt  acaggcatt  900
tagaacact  aagaactta  atggtagac  aataatagt  aatttgctt  gatctaagg  960
aggtgaaca  atgctaagt  aagctttcc  gagtcattt  aaagcttct  aacatgctg  1020
tgatatcca  atggtgaat  ttgactatc  tcaaatggt  aagggagga  aggcagaaa  1080
attacatag  gttcttaaa  ctcaagtcc  gaagtttct  gattatgga  ttttttatt  1140
caatggaag  gaagttcaa  gatgccaga  tggtacagt  cgaacaaac  gcttggatt  1200
tcttgatag  acaaatagt  tgcaggcat  tcttggctt  gagatgcta  ctaaacagt  1260
ggaagctct  ggtttagct  aaaagcctc  gttggtgac  cgctttcaa  aagtttttc  1320
gtcaatgtg  tccgtgaat  gtgattcaa  cagtaagat  tatgcagga  ctggagctc  1380
tgaagggaa  gcgaagtta  aagatggtg  tcgctctgt  acccgaaca  ttcagaata  1440
cttctttga  agctccaag  aagaggcca  tgatgtttt  ctactggga  atactctga  1500
tagtgattt  gctgacaaa  ctcgagcac  tttaactac  ggaagtttg  gtgtttctg  1560
gcagacatt  cagtcagca  cttctaaag  actaaagag  atgtgtgag  atttctaca  1620
atattcaaa  cctaagaaa  ttcgagtat  tgtcggaac  tggaatgtg  atggtggga  1680
gcaatttcg  agcatagct  ttaagaatc  gacactcac  gactggctt  ttgatgcac  1740
caagttagc  ggcatccag  agtttcaag  taaaagaag  aagccaact  atatatttg  1800
aattggttt  gaagaaatg  tagaattga  tgctggaaa  attgtgagt  caagcacaa  1860
aaatcagaa  ctctgggct  tagaacttc  gaagacaat  tccagagac  acaagtatg  1920
gctgctggc  tctgaacag  tggtgggcg  ctgtttgtt  gtttttatc  gaccacagc  1980
tgctccttt  atcagggat  ttgcagttg  tactgtgaa  actggaatg  gaggtgcaa  2040
tggaaataa  ggagcagtt  caatccgaa  gctcttcca  acaaccagc  tttgcttcg  2100
ctgtagcca  tttgctgca  ggcagtcac  agtcaaaga  agaaatgaa  attttatag  2160
aatagcacg  aaattgagt  ttcctatgg  aaggatgct  ttttcccat  actatgtat  2220
ttggtgtgg  gatttcaac  atcgaatcg  tctccctaa  gaagaagtt  aagagctca  2280
aagacagca  aattgggat  ctcttatag  aggagatca  cttatcaat  agaaaaatg  2340
tggacaggt  tttagagga  ttttagaag  aaaggtaac  tttgctccg  catataagt  2400
tgacttgtt  tctgacgac  atgacacca  tgaaaagtg  cgcacccct  cctggacag  2460
ccgtgtcct  tggagaagg  ggaaatggc  ttttgatag  tcagctgaa  atctagatc  2520
tctaaatgc  agttttcaa  atgaaagca  aattctgta  acgtggact  caggcactt  2580
gctgcacta  ggaagagct  agctgaaga  ttctgacca  aggcctgtc  ttgccctga  2640
tgatataga  atatttgaa  ttgaagctg  agagaggca  aacatttat  aagaagtaa  2700
tgcagttca  ggtccacca  atggtacag  attggtctc  atcaaaagt  ctttaccag  2760
aaataattt  tttgatgat  ccttgattg  tgagcttct  cagcagttt  caagttttg  2820
tgaagttat  cttataaga  ttgtagaag  taaaatgtg  gttacattt  tggagggaa  2880
ctctgcctt  aatgttctg  gcctaaatg  taaagagtt  ttgaatcgg  ctataacta  2940
tgctttaaa  agtccagac  ggatcaaaa  tttggaaga  gaaatgagt  tagagaaaa  3000
tagcattgc  ttgccatca  caacaagct  taccctgct  ggtgaagat  cagaggttg  3060
agcagattt  gatatggaa  gtgatgttg  tgactatag  gctgaagtg  aggaacttc  3120
tcctcagca  ctccagcca  cttcaagtt  cggccttgg  acttccccc  gctcttcac  3180
ccgaactag  ccctgccag  cacctacaa  atcagaggg  cctgtacct  cccttccca  3240
cagaccaag  cgagcaccg  caagaactc  tgggcctcc  agtgcacag  gttctccta  3300
tgacgcgca  ccagcaacg  cgctgccgc  gaaagaccc  gcccagccc  tggagccca  3360
gcggccgcc  ccgccccgc  cggtcgccc  tcccacacg  ccggctccc  cacagagac  3420
tcctccgcc  tcaggggct  ggagtcctg  acccactag  aaggaattt  gaggtattg  3480
agcccctcc  agtcctggg  tagctagga  agagatgga  gcacccaaa  gccctggaa  3540
aacaaggaa  gataatata  gacgcagtc  gccttcacc  caagcagga  ttgcaggcc  3600
aggacctgc  ggatacagt  cagccagac  gacgattcc  cctcgtgct  gagttatca  3660
tgccccaca  agccacgcg  gggcatctg  tggaagact  actcctgaa  gccaaagca  3720
aacatcaga  acgtcgaaa  gttcaactt  ccttcctga  ccactgaag  ctcaggctg  3780
ttttcctcc  cagtcttct  tgcccccgc  tgctcaaag  ttgcaagag  ctcttgtcc  3840
tgtggcagc  cctatgcct  agtctggcc  ccagccaaa  ttggaaacc  caccacaac  3900
accacctcg  agcaggtca  cccatagct  gccttcaga  gcttcctca  aaccgcaac  3960
ggagcaacc  tcagggtaa  aggtaaaaa  aaatggaat  tctgatggc  aaagagaat  4020
accattaaa  attgaccca  ttgaagatc  gtcatttaa  ctgcttgct  tatcaaagg  4080
tcagctatc  gttcaaacg  cacctgttc  caccccaga  ccaaagagg  tgattcagt  4140
gccttctgc  acgcaaagt  atgttaata  tttgagttc  gtaagttgc  tgccaacaa  4200
gcctccaat  ccagctcgg  gtcaatccc  ggaaaatat  cgaagttct  caaacccat  4260
tattactgg  ttgaccagg  caaatcctt  cagtgacag  actgctgct  ctggaaacc  4320
atttagagc  aagtctgaa  aatcagagg  aacttcatg  ttctccaaa  aagagcccg  4380
tactatcag  cctttccct  ctctgcagc  tcttggtca  aacaaaagc  gggcttcat  4440
ttcacttga  ggctttaag  acagttttg  tctacaggg  cagtctaca  taaaaatta  4500
caacccgaa  ggatgggta  ccttcgagg  agaagagga  tttggtgtg  aagggaagt  4560
aaagtcagc  tgttcagac  tactgggta  tcagccaag  tcattttct  gctccaacc  4620
gacattgaa  gatgactgg  ataaaggga  aaatgtctc  ttctgtgtg  tgccgtcaa  4680
aagacctcc  ccacctcct  tccctctgc  cccgcccgg  accagccct  cagtagatc  4740
tttcacgac  ttggcctct  aggcttcac  cacactgga  tttacagaa  gataacgcc  4800
gcccg  4805



<210> 1403
<211> 1575
<212> PRT
<213> Homo sapiens
<308> O43426
<400> 1403

Met Ala Phe Ser Lys Gly Phe Arg Ile Tyr His Lys Leu Asp Pro Pro 
  1               5                  10                  15
Pro Phe Ser Leu Ile Val Glu Thr Arg His Lys Glu Glu Cys Leu Met 
             20                  25                  30
Phe Glu Ser Gly Ala Val Ala Val Leu Ser Ser Ala Glu Lys Glu Ala 
         35                  40                  45
Ile Lys Gly Thr Tyr Ser Lys Val Leu Asp Ala Tyr Gly Leu Leu Gly 
     50                  55                  60
Val Leu Arg Leu Asn Leu Gly Asp Thr Met Leu His Tyr Leu Val Leu 
 65                  70                  75                  80
Val Thr Gly Cys Met Ser Val Gly Lys Ile Gln Glu Ser Glu Val Phe 
                 85                  90                  95
Arg Val Thr Ser Thr Glu Phe Ile Ser Leu Arg Ile Asp Ser Ser Asp 
             100                105                110
Glu Asp Arg Ile Ser Glu Val Arg Lys Val Leu Asn Ser Gly Asn Phe 
         115                120                125
Tyr Phe Ala Trp Ser Ala Ser Gly Ile Ser Leu Asp Leu Ser Leu Asn 
     130                135                140
Ala His Arg Ser Met Gln Glu Gln Thr Thr Asp Asn Arg Phe Phe Trp 
 145                150                155                160
Asn Gln Ser Leu His Leu His Leu Lys His Tyr Gly Val Asn Cys Asp 
                 165                170                175
Asp Trp Leu Leu Arg Leu Met Cys Gly Gly Val Glu Ile Arg Thr Ile 
             180                185                190
Tyr Ala Ala His Lys Gln Ala Lys Ala Cys Leu Ile Ser Arg Leu Ser 
         195                200                205
Cys Glu Arg Ala Gly Thr Arg Phe Asn Val Arg Gly Thr Asn Asp Asp 
     210                215                220
Gly His Val Ala Asn Phe Val Glu Thr Glu Gln Val Val Tyr Leu Asp 
 225                230                235                240
Asp Ser Val Ser Ser Phe Ile Gln Ile Arg Gly Ser Val Pro Leu Phe 
                 245                250                255
Trp Glu Gln Pro Gly Leu Gln Val Gly Ser His Arg Val Arg Met Ser 
             260                265                270
Arg Gly Phe Glu Ala Asn Ala Pro Ala Phe Asp Arg His Phe Arg Thr 
         275                280                285
Leu Lys Asn Leu Tyr Gly Arg Gln Ile Ile Val Asn Leu Leu Gly Ser 
     290                295                300
Lys Glu Gly Glu His Met Leu Ser Lys Ala Phe Gln Ser His Leu Lys 
 305                310                315                320
Ala Ser Glu His Ala Ala Asp Ile Gln Met Val Asn Phe Asp Tyr His 
                 325                330                335
Gln Met Val Lys Gly Gly Lys Ala Glu Lys Leu His Ser Val Leu Lys 
             340                345                350
Pro Gln Val Gln Lys Phe Leu Asp Tyr Gly Phe Phe Tyr Phe Asn Gly 
         355                360                365
Ser Glu Val Gln Arg Cys Gln Ser Gly Thr Val Arg Thr Asn Cys Leu 
     370                375                380
Asp Cys Leu Asp Arg Thr Asn Ser Val Gln Ala Phe Leu Gly Leu Glu 
 385                390                395                400
Met Leu Ala Lys Gln Leu Glu Ala Leu Gly Leu Ala Glu Lys Pro Gln 
                 405                410                415
Leu Val Thr Arg Phe Gln Glu Val Phe Arg Ser Met Trp Ser Val Asn 
             420                425                430
Gly Asp Ser Ile Ser Lys Ile Tyr Ala Gly Thr Gly Ala Leu Glu Gly 
         435                440                445
Lys Ala Lys Leu Lys Asp Gly Ala Arg Ser Val Thr Arg Thr Ile Gln 
     450                455                460
Asn Asn Phe Phe Asp Ser Ser Lys Gln Glu Ala Ile Asp Val Leu Leu 
 465                470                475                480
Leu Gly Asn Thr Leu Asn Ser Asp Leu Ala Asp Lys Ala Arg Ala Leu 
                 485                490                495
Leu Thr Thr Gly Ser Leu Arg Val Ser Glu Gln Thr Leu Gln Ser Ala 
             500                505                510
Ser Ser Lys Val Leu Lys Ser Met Cys Glu Asn Phe Tyr Lys Tyr Ser 
         515                520                525
Lys Pro Lys Lys Ile Arg Val Cys Val Gly Thr Trp Asn Val Asn Gly 
     530                535                540
Gly Lys Gln Phe Arg Ser Ile Ala Phe Lys Asn Gln Thr Leu Thr Asp 
 545                550                555                560
Trp Leu Leu Asp Ala Pro Lys Leu Ala Gly Ile Gln Glu Phe Gln Asp 
                 565                570                575
Lys Arg Ser Lys Pro Thr Asp Ile Phe Ala Ile Gly Phe Glu Glu Met 
             580                585                590
Val Glu Leu Asn Ala Gly Asn Ile Val Ser Ala Ser Thr Thr Asn Gln 
         595                600                605
Lys Leu Trp Ala Val Glu Leu Gln Lys Thr Ile Ser Arg Asp Asn Lys 
     610                615                620
Tyr Val Leu Leu Ala Ser Glu Gln Leu Val Gly Val Cys Leu Phe Val 
 625                630                635                640
Phe Ile Arg Pro Gln His Ala Pro Phe Ile Arg Asp Val Ala Val Asp 
                 645                650                655
Thr Val Lys Thr Gly Met Gly Gly Ala Thr Gly Asn Lys Gly Ala Val 
             660                665                670
Ala Ile Arg Met Leu Phe His Thr Thr Ser Leu Cys Phe Val Cys Ser 
         675                680                685
His Phe Ala Ala Gly Gln Ser Gln Val Lys Glu Arg Asn Glu Asp Phe 
     690                695                700
Ile Glu Ile Ala Arg Lys Leu Ser Phe Pro Met Gly Arg Met Leu Phe 
 705                710                715                720
Ser His Asp Tyr Val Phe Trp Cys Gly Asp Phe Asn Tyr Arg Ile Asp 
                 725                730                735
Leu Pro Asn Glu Glu Val Lys Glu Leu Ile Arg Gln Gln Asn Trp Asp 
             740                745                750
Ser Leu Ile Ala Gly Asp Gln Leu Ile Asn Gln Lys Asn Ala Gly Gln 
         755                760                765
Val Phe Arg Gly Phe Leu Glu Gly Lys Val Thr Phe Ala Pro Thr Tyr 
     770                775                780
Lys Tyr Asp Leu Phe Ser Asp Asp Tyr Asp Thr Ser Glu Lys Cys Arg 
 785                790                795                800
Thr Pro Ala Trp Thr Asp Arg Val Leu Trp Arg Arg Arg Lys Trp Pro 
                 805                810                815
Phe Asp Arg Ser Ala Glu Asp Leu Asp Leu Leu Asn Ala Ser Phe Gln 
             820                825                830
Asp Glu Ser Lys Ile Leu Tyr Thr Trp Thr Pro Gly Thr Leu Leu His 
         835                840                845
Tyr Gly Arg Ala Glu Leu Lys Thr Ser Asp His Arg Pro Val Val Ala 
     850                855                860
Leu Ile Asp Ile Asp Ile Phe Glu Val Glu Ala Glu Glu Arg Gln Asn 
 865                870                875                880
Ile Tyr Lys Glu Val Ile Ala Val Gln Gly Pro Pro Asp Gly Thr Val 
                 885                890                895
Leu Val Ser Ile Lys Ser Ser Leu Pro Glu Asn Asn Phe Phe Asp Asp 
             900                905                910
Ala Leu Ile Asp Glu Leu Leu Gln Gln Phe Ala Ser Phe Gly Glu Val 
         915                920                925
Ile Leu Ile Arg Phe Val Glu Asp Lys Met Trp Val Thr Phe Leu Glu 
     930                935                940
Gly Ser Ser Ala Leu Asn Val Leu Ser Leu Asn Gly Lys Glu Leu Leu 
 945                950                955                960
Asn Arg Thr Ile Thr Ile Ala Leu Lys Ser Pro Asp Trp Ile Lys Asn 
                 965                970                975
Leu Glu Glu Glu Met Ser Leu Glu Lys Ile Ser Ile Ala Leu Pro Ser 
             980                985                990
Ser Thr Ser Ser Thr Leu Leu Gly Glu Asp Ala Glu Val Ala Ala Asp 
         995                1000                1005
Phe Asp Met Glu Gly Asp Val Asp Asp Tyr Ser Ala Glu Val Glu Glu 
     1010                1015                1020
Leu Leu Pro Gln His Leu Gln Pro Ser Ser Ser Ser Gly Leu Gly Thr 
 1025                1030                1035                1040
Ser Pro Ser Ser Ser Pro Arg Thr Ser Pro Cys Gln Ser Pro Thr Ile 
                 1045                1050                1055
Ser Glu Gly Pro Val Pro Ser Leu Pro Ile Arg Pro Ser Arg Ala Pro 
             1060                1065                1070
Ser Arg Thr Pro Gly Pro Pro Ser Ala Gln Ser Ser Pro Ile Asp Ala 
         1075                1080                1085
Gln Pro Ala Thr Pro Leu Pro Gln Lys Asp Pro Ala Gln Pro Leu Glu 
     1090                1095                1100
Pro Lys Arg Pro Pro Pro Pro Arg Pro Val Ala Pro Pro Thr Arg Pro 
 1105                1110                1115                1120
Ala Pro Pro Gln Arg Pro Pro Pro Pro Ser Gly Ala Arg Ser Pro Ala 
                 1125                1130                1135
Pro Thr Arg Lys Glu Phe Gly Gly Ile Gly Ala Pro Pro Ser Pro Gly 
             1140                1145                1150
Val Ala Arg Arg Glu Met Glu Ala Pro Lys Ser Pro Gly Thr Thr Arg 
         1155                1160                1165
Lys Asp Asn Ile Gly Arg Ser Gln Pro Ser Pro Gln Ala Gly Leu Ala 
     1170                1175                1180
Gly Pro Gly Pro Ala Gly Tyr Ser Thr Ala Arg Pro Thr Ile Pro Pro 
 1185                1190                1195                1200
Arg Ala Gly Val Ile Ser Ala Pro Gln Ser His Ala Arg Ala Ser Ala 
                 1205                1210                1215
Gly Arg Leu Thr Pro Glu Ser Gln Ser Lys Thr Ser Glu Thr Ser Lys 
             1220                1225                1230
Gly Ser Thr Phe Leu Pro Glu Pro Leu Lys Pro Gln Ala Ala Phe Pro 
         1235                1240                1245
Pro Gln Ser Ser Leu Pro Pro Pro Ala Gln Arg Leu Gln Glu Pro Leu 
     1250                1255                1260
Val Pro Val Ala Ala Pro Met Pro Gln Ser Gly Pro Gln Pro Asn Leu 
 1265                1270                1275                1280
Glu Thr Pro Pro Gln Pro Pro Pro Arg Ser Arg Ser Ser His Ser Leu 
                 1285                1290                1295
Pro Ser Glu Ala Ser Ser Gln Pro Gln Val Lys Thr Asn Gly Ile Ser 
             1300                1305                1310
Asp Gly Lys Arg Glu Ser Pro Leu Lys Ile Asp Pro Phe Glu Asp Leu 
         1315                1320                1325
Ser Phe Asn Leu Leu Ala Val Ser Lys Ala Gln Leu Ser Val Gln Thr 
     1330                1335                1340
Ser Pro Val Pro Thr Pro Asp Pro Lys Arg Leu Ile Gln Leu Pro Ser 
 1345                1350                1355                1360
Ala Thr Gln Ser Asn Val Asn Thr Leu Ser Ser Val Ser Cys Met Pro 
                 1365                1370                1375
Thr Met Pro Pro Ile Pro Ala Arg Ser Gln Ser Gln Glu Asn Met Arg 
             1380                1385                1390
Ser Ser Pro Asn Pro Phe Ile Thr Gly Leu Thr Arg Thr Asn Pro Phe 
         1395                1400                1405
Ser Asp Arg Thr Ala Ala Pro Gly Asn Pro Phe Arg Ala Lys Ser Glu 
     1410                1415                1420
Glu Ser Glu Ala Thr Ser Trp Phe Ser Lys Glu Glu Pro Val Thr Ile 
 1425                1430                1435                1440
Ser Pro Phe Pro Ser Leu Gln Pro Leu Gly His Asn Lys Ser Arg Ala 
                 1445                1450                1455
Ser Ser Ser Leu Asp Gly Phe Lys Asp Ser Phe Asp Leu Gln Gly Gln 
             1460                1465                1470
Ser Thr Leu Lys Ile Ser Asn Pro Lys Gly Trp Val Thr Phe Glu Glu 
         1475                1480                1485
Glu Glu Asp Phe Gly Val Lys Gly Lys Ser Lys Ser Ala Cys Ser Asp 
     1490                1495                1500
Leu Leu Gly Asn Gln Pro Ser Ser Phe Ser Gly Ser Asn Leu Thr Leu 
 1505                1510                1515                1520
Asn Asp Asp Trp Asn Lys Gly Thr Asn Val Ser Phe Cys Val Leu Pro 
                 1525                1530                1535
Ser Arg Arg Pro Pro Pro Pro Pro Val Pro Leu Leu Pro Pro Gly Thr 
             1540                1545                1550
Ser Pro Pro Val Asp Pro Phe Thr Thr Leu Ala Ser Lys Ala Ser Pro 
         1555                1560                1565
Thr Leu Asp Phe Thr Glu Arg 
     1570                1575



<210> 1404
<211> 1514
<212> DNA
<213> Rattus norvegicus
<308> AJ006971
<400> 1404

tgaacccgc  ggtttgcac  ggaggctct  gcgggggcc  cgctggccc  gggcgggga  60
tcgcgggct  aggacgctc  tgtgtcccc  gaatcctgc  gaaggacag  gccatgtcc  120
cgttcaggc  ggaggacgt  gaggaccat  atgagatgg  agaggagct  ggcagcggc  180
agttcgcca  cgtgcgcaa  tgccagcag  agggcaccg  catggagta  gcggccaag  240
tcataaaga  gcggcgcct  ccgtccagc  ggcgcggtg  gagccgtga  gagatcgag  300
gcgaggtga  catcctgcg  gagatccgc  accccaaca  catcacgct  cacgatgtg  360
tcgagaaca  gacagatgt  gtgctgatc  tggagctgg  gtccggcgg  gaacttttc  420
actttctgg  tgagaagga  tcactgaca  aggatgagg  cacgcagtt  ctcaagcag  480
tcctggacg  tgtccacta  ctgcactcc  agcgcatcg  gcactttga  ctgaagccg  540
agaacatca  gttgctgga  aagcatgca  ccagcccac  cattaagct  atcgacttt  600
gcatcgcgc  caggatcga  gccggtagc  agttcaaga  catctttgg  acgccagag  660
tcgtcgccc  tgagattgt  aactatgaa  cacttggct  ggaagctga  atgtggagc  720
tcggcgtca  cacctacat  ctcctgagc  gggcttccc  attcctggg  gagaccaag  780
aggaaacgc  gacaaacat  tcggctgtg  actatgact  tgatgaaga  tacttcagc  840
gcaccagtg  actggccaa  gacttcatc  gaaggctgc  ggtcaaaga  cccaagagg  900
ggatgacca  cgcacagag  ctggagcat  cctggatca  ggttcgccg  cgtgaggac  960
gcgcccgga  gccagagcg  cgccgactg  gcgcggcgc  cctgcgcga  tacagtctc  1020
agtcgcact  aagcatgcc  cgaaacacg  gctacgcca  cttcgagcg  ttctcgcgc  1080
tgctggagg  cgtggcggc  gcggagcag  ggctgcgcg  gctgcagcg  ggccggcgg  1140
agtgccggg  gcgcgtgtg  gcgctgcgc  tggctgcgg  acagcggga  gcgcgctgc  1200
gcgacggga  cgccgggct  ggccgcgac  tgcgacgcc  gcgcacgga  ctgggtcgc  1260
ccgaggctc  gcgcacgcg  gcgcaggag  aggcacggg  agcgctctt  ggcgctggt  1320
gcctgaaac  tcgcctgtg  cgccttgag  accgctacg  cgcgctagc  gcacaggtg  1380
ctgctgagg  gcagttcgt  cgcgatctg  tacgcgcgc  ggagcagga  cggctgcag  1440
ccgagtgcg  cgtgcgcta  gctgcgaca  ccccagatc  ccggccatc  ccagaataa  1500
gctactttc  acgc  1514



<210> 1405
<211> 448
<212> PRT
<213> Rattus norvegicus
<308> CAA07360
<400> 1405

Met Ser Thr Phe Arg Gln Glu Asp Val Glu Asp His Tyr Glu Met Gly 
  1               5                  10                  15
Glu Glu Leu Gly Ser Gly Gln Phe Ala Ile Val Arg Lys Cys Gln Gln 
             20                  25                  30
Lys Gly Thr Gly Met Glu Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
         35                  40                  45
Leu Pro Ser Ser Arg Arg Gly Val Ser Arg Glu Glu Ile Glu Arg Glu 
     50                  55                  60
Val Ser Ile Leu Arg Glu Ile Arg His Pro Asn Ile Ile Thr Leu His 
 65                  70                  75                  80
Asp Val Phe Glu Asn Lys Thr Asp Val Val Leu Ile Leu Glu Leu Val 
                 85                  90                  95
Ser Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 
             100                105                110
Glu Asp Glu Ala Thr Gln Phe Leu Lys Gln Ile Leu Asp Gly Val His 
         115                120                125
Tyr Leu His Ser Lys Arg Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
     130                135                140
Ile Met Leu Leu Asp Lys His Ala Ala Ser Pro Arg Ile Lys Leu Ile 
 145                150                155                160
Asp Phe Gly Ile Ala His Arg Ile Glu Ala Gly Ser Glu Phe Lys Asn 
                 165                170                175
Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
             180                185                190
Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 
         195                200                205
Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Glu Thr Lys Gln Glu 
     210                215                220
Thr Leu Thr Asn Ile Ser Ala Val Asn Tyr Asp Phe Asp Glu Glu Tyr 
 225                230                235                240
Phe Ser Ser Thr Ser Glu Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                 245                250                255
Val Lys Asp Pro Lys Arg Arg Met Thr Ile Ala Gln Ser Leu Glu His 
             260                265                270
Ser Trp Ile Lys Val Arg Arg Arg Glu Asp Gly Ala Arg Lys Pro Glu 
         275                280                285
Arg Arg Arg Leu Arg Ala Ala Arg Leu Arg Glu Tyr Ser Leu Lys Ser 
     290                295                300
His Ser Ser Met Pro Arg Asn Thr Ser Tyr Ala Ser Phe Glu Arg Phe 
 305                310                315                320
Ser Arg Val Leu Glu Asp Val Ala Ala Ala Glu Gln Gly Leu Arg Glu 
                 325                330                335
Leu Gln Arg Gly Arg Arg Gln Cys Arg Glu Arg Val Cys Ala Leu Arg 
             340                345                350
Val Ala Ala Glu Gln Arg Glu Ala Arg Cys Arg Asp Gly Ser Ala Gly 
         355                360                365
Leu Gly Arg Asp Leu Arg Arg Leu Arg Thr Glu Leu Gly Arg Thr Glu 
     370                375                380
Ala Leu Arg Thr Arg Ala Gln Glu Glu Ala Arg Ala Ala Leu Leu Gly 
 385                390                395                400
Ala Gly Gly Leu Lys Arg Arg Leu Cys Arg Leu Glu Asn Arg Tyr Asp 
                 405                410                415
Ala Leu Ala Ala Gln Val Ala Ala Glu Val Gln Phe Val Arg Asp Leu 
             420                425                430
Val Arg Ala Leu Glu Gln Glu Arg Leu Gln Ala Glu Cys Gly Val Arg 
         435                440                445



<210> 1406
<211> 2055
<212> DNA
<213> Homo sapiens
<308> AB022341
<400> 1406

gcactttcc  tggagtgga  gctgctgga  ggcggaccg  ccgccatgt  cacgttcag  60
caggaggac  tggaggacc  ttatgagat  ggggaggag  tgggcagcg  ccagtttgc  120
atcgtgcgg  agtgccggc  gaagggcac  ggcaaggag  acgcagcca  gttcatcaa  180
aagcgccgc  tgtcatcca  ccggcgtgg  gtgagccgg  aggagatcg  gcgggaggt  240
aacatcctg  gggagatcc  gcaccccaa  atcatcacc  tgcacgaca  cttcgagaa  300
aagacggac  tggtcctca  cctggagct  gtctctggc  gggagctct  tgacttcct  360
gcggagaag  agtcgctga  ggaggacga  gccacccag  tcctcaagc  gatcctgga  420
ggcgttcac  acctgcact  taagcgcat  gcacacttt  acctgaagc  ggaaaacat  480
atgctgctg  acaagaacg  gcccaaccc  cgaatcaag  tcatcgact  cggcatcgc  540
cacaagatc  aggcgggga  cgagttcaa  aacatcttc  gcaccccgg  gtttgtggc  600
ccagagatt  tgaactatg  gccgctggg  ctggaggcg  acatgtgga  catcggtgt  660
atcacctat  tcctcctga  cggtgcatc  ccgttcctg  gcgagacca  gcaggagac  720
ctcaccaac  tctcagccg  gaactacga  ttcgacgag  agtacttca  caacaccag  780
gagctggcc  aggacttca  tcgccggct  ctcgtcaaa  atcccaagc  gagaatgac  840
attgcccag  gcctggaac  ttcctggat  aaggcgatc  ggcggcgga  cgtgcgtgg  900
gaggacagc  gccgcaagc  cgagcggcg  cgcctgaag  ccacgcgtc  gaaggagta  960
accatcaag  cgcactcca  cttgccgcc  aacaacagc  acgccgact  cgagcgctt  1020
tccaaggtg  tggaggagg  ggcggccgc  gaggagggc  tgcgcgagc  gcagcgcag  1080
cggcggctc  gccacgagg  cgtggaggc  ctggccgcc  tctacgagg  gaaggaggc  1140
tggtaccgc  aggagagcg  cagcctggg  caggacctg  ggaggctac  gcaggagct  1200
ctcaagacc  aggcgctca  gcggcaggc  caggaggag  ccaagggcg  gctgctggg  1260
accagcggc  tcaagcgcc  cttcagccg  ctggagaac  gctacgagg  gctggccaa  1320
caagtagcc  ccgagatgc  cttcgtgca  gacctcgtg  gcgccctgg  gcaggagaa  1380
ctgcagggc  tggagtgcg  gctgcgcta  gcgcagtgg  gtgggccag  ccccaggac  1440
gccggagct  ggcctgcgg  gggggcgct  cctgtggac  ctgcgcctc  catcgcccg  1500
gtgcctgtc  ttgcccagc  ccaccaggc  ggaggcgga  tgggaggag  tggagccag  1560
cccgtaagt  cgcaggcag  ggtgggtgt  ggacggggc  gcttctcta  acatcctcc  1620
cgctggcct  caccttcac  cctgcatcg  cggtgaccc  gggaccctc  aggcagcgt  1680
gcctgtggc  ccgtgaggg  tgggaccca  cgaggcgca  aggcggccc  aatgcagcc  1740
tggttcagg  ccggaggag  gtttgcggg  agttgcacg  acaattcgg  ggggtgctg  1800
ctgttgctg  cattagccc  ggaggaggt  gtgggacgg  gagggtggg  tggacggcg  1860
acaggcagt  cccacgctg  tgggtggcg  cgggcttgg  ggggtcttc  actgtgtgc  1920
cttctcgcc  aggccggtc  cccgggtgt  gggtgccct  ctgcggact  ctccgcgag  1980
cccatcgtc  cgcctgtgg  cgcctaggc  agagcggcc  tctgcagcc  agagaaata  2040
aatactggc  tccag  2055



<210> 1407
<211> 454
<212> PRT
<213> Homo sapiens
<308> NP_001339
<400> 1407

Met Ser Thr Phe Arg Gln Glu Asp Val Glu Asp His Tyr Glu Met Gly 
  1               5                  10                  15
Glu Glu Leu Gly Ser Gly Gln Phe Ala Ile Val Arg Lys Cys Arg Gln 
             20                  25                  30
Lys Gly Thr Gly Lys Glu Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
         35                  40                  45
Leu Ser Ser Ser Arg Arg Gly Val Ser Arg Glu Glu Ile Glu Arg Glu 
     50                  55                  60
Val Asn Ile Leu Arg Glu Ile Arg His Pro Asn Ile Ile Thr Leu His 
 65                  70                  75                  80
Asp Ile Phe Glu Asn Lys Thr Asp Val Val Leu Ile Leu Glu Leu Val 
                 85                  90                  95
Ser Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 
             100                105                110
Glu Asp Glu Ala Thr Gln Phe Leu Lys Gln Ile Leu Asp Gly Val His 
         115                120                125
Tyr Leu His Ser Lys Arg Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
     130                135                140
Ile Met Leu Leu Asp Lys Asn Val Pro Asn Pro Arg Ile Lys Leu Ile 
 145                150                155                160
Asp Phe Gly Ile Ala His Lys Ile Glu Ala Gly Asn Glu Phe Lys Asn 
                 165                170                175
Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
             180                185                190
Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 
         195                200                205
Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Glu Thr Lys Gln Glu 
     210                215                220
Thr Leu Thr Asn Ile Ser Ala Val Asn Tyr Asp Phe Asp Glu Glu Tyr 
 225                230                235                240
Phe Ser Asn Thr Ser Glu Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                 245                250                255
Val Lys Asp Pro Lys Arg Arg Met Thr Ile Ala Gln Ser Leu Glu His 
             260                265                270
Ser Trp Ile Lys Ala Ile Arg Arg Arg Asn Val Arg Gly Glu Asp Ser 
         275                280                285
Gly Arg Lys Pro Glu Arg Arg Arg Leu Lys Thr Thr Arg Leu Lys Glu 
     290                295                300
Tyr Thr Ile Lys Ser His Ser Ser Leu Pro Pro Asn Asn Ser Tyr Ala 
 305                310                315                320
Asp Phe Glu Arg Phe Ser Lys Val Leu Glu Glu Ala Ala Ala Ala Glu 
                 325                330                335
Glu Gly Leu Arg Glu Leu Gln Arg Ser Arg Arg Leu Cys His Glu Asp 
             340                345                350
Val Glu Ala Leu Ala Ala Ile Tyr Glu Glu Lys Glu Ala Trp Tyr Arg 
         355                360                365
Glu Glu Ser Asp Ser Leu Gly Gln Asp Leu Arg Arg Leu Arg Gln Glu 
     370                375                380
Leu Leu Lys Thr Glu Ala Leu Lys Arg Gln Ala Gln Glu Glu Ala Lys 
 385                390                395                400
Gly Ala Leu Leu Gly Thr Ser Gly Leu Lys Arg Arg Phe Ser Arg Leu 
                 405                410                415
Glu Asn Arg Tyr Glu Ala Leu Ala Lys Gln Val Ala Ser Glu Met Arg 
             420                425                430
Phe Val Gln Asp Leu Val Arg Ala Leu Glu Gln Glu Lys Leu Gln Gly 
         435                440                445
Val Glu Cys Gly Leu Arg 
     450



<210> 1408
<211> 1514
<212> DNA
<213> Rattus norvegicus
<308> AJ006971
<400> 1408

tgaacccgc  ggtttgcac  ggaggctct  gcgggggcc  cgctggccc  gggcgggga  60
tcgcgggct  aggacgctc  tgtgtcccc  gaatcctgc  gaaggacag  gccatgtcc  120
cgttcaggc  ggaggacgt  gaggaccat  atgagatgg  agaggagct  ggcagcggc  180
agttcgcca  cgtgcgcaa  tgccagcag  agggcaccg  catggagta  gcggccaag  240
tcataaaga  gcggcgcct  ccgtccagc  ggcgcggtg  gagccgtga  gagatcgag  300
gcgaggtga  catcctgcg  gagatccgc  accccaaca  catcacgct  cacgatgtg  360
tcgagaaca  gacagatgt  gtgctgatc  tggagctgg  gtccggcgg  gaacttttc  420
actttctgg  tgagaagga  tcactgaca  aggatgagg  cacgcagtt  ctcaagcag  480
tcctggacg  tgtccacta  ctgcactcc  agcgcatcg  gcactttga  ctgaagccg  540
agaacatca  gttgctgga  aagcatgca  ccagcccac  cattaagct  atcgacttt  600
gcatcgcgc  caggatcga  gccggtagc  agttcaaga  catctttgg  acgccagag  660
tcgtcgccc  tgagattgt  aactatgaa  cacttggct  ggaagctga  atgtggagc  720
tcggcgtca  cacctacat  ctcctgagc  gggcttccc  attcctggg  gagaccaag  780
aggaaacgc  gacaaacat  tcggctgtg  actatgact  tgatgaaga  tacttcagc  840
gcaccagtg  actggccaa  gacttcatc  gaaggctgc  ggtcaaaga  cccaagagg  900
ggatgacca  cgcacagag  ctggagcat  cctggatca  ggttcgccg  cgtgaggac  960
gcgcccgga  gccagagcg  cgccgactg  gcgcggcgc  cctgcgcga  tacagtctc  1020
agtcgcact  aagcatgcc  cgaaacacg  gctacgcca  cttcgagcg  ttctcgcgc  1080
tgctggagg  cgtggcggc  gcggagcag  ggctgcgcg  gctgcagcg  ggccggcgg  1140
agtgccggg  gcgcgtgtg  gcgctgcgc  tggctgcgg  acagcggga  gcgcgctgc  1200
gcgacggga  cgccgggct  ggccgcgac  tgcgacgcc  gcgcacgga  ctgggtcgc  1260
ccgaggctc  gcgcacgcg  gcgcaggag  aggcacggg  agcgctctt  ggcgctggt  1320
gcctgaaac  tcgcctgtg  cgccttgag  accgctacg  cgcgctagc  gcacaggtg  1380
ctgctgagg  gcagttcgt  cgcgatctg  tacgcgcgc  ggagcagga  cggctgcag  1440
ccgagtgcg  cgtgcgcta  gctgcgaca  ccccagatc  ccggccatc  ccagaataa  1500
gctactttc  acgc  1514



<210> 1409
<211> 448
<212> PRT
<213> Rattus norvegicus
<308> CAA07360
<400> 1409

Met Ser Thr Phe Arg Gln Glu Asp Val Glu Asp His Tyr Glu Met Gly 
  1               5                  10                  15
Glu Glu Leu Gly Ser Gly Gln Phe Ala Ile Val Arg Lys Cys Gln Gln 
             20                  25                  30
Lys Gly Thr Gly Met Glu Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
         35                  40                  45
Leu Pro Ser Ser Arg Arg Gly Val Ser Arg Glu Glu Ile Glu Arg Glu 
     50                  55                  60
Val Ser Ile Leu Arg Glu Ile Arg His Pro Asn Ile Ile Thr Leu His 
 65                  70                  75                  80
Asp Val Phe Glu Asn Lys Thr Asp Val Val Leu Ile Leu Glu Leu Val 
                 85                  90                  95
Ser Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 
             100                105                110
Glu Asp Glu Ala Thr Gln Phe Leu Lys Gln Ile Leu Asp Gly Val His 
         115                120                125
Tyr Leu His Ser Lys Arg Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
     130                135                140
Ile Met Leu Leu Asp Lys His Ala Ala Ser Pro Arg Ile Lys Leu Ile 
 145                150                155                160
Asp Phe Gly Ile Ala His Arg Ile Glu Ala Gly Ser Glu Phe Lys Asn 
                 165                170                175
Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
             180                185                190
Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 
         195                200                205
Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Glu Thr Lys Gln Glu 
     210                215                220
Thr Leu Thr Asn Ile Ser Ala Val Asn Tyr Asp Phe Asp Glu Glu Tyr 
 225                230                235                240
Phe Ser Ser Thr Ser Glu Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                 245                250                255
Val Lys Asp Pro Lys Arg Arg Met Thr Ile Ala Gln Ser Leu Glu His 
             260                265                270
Ser Trp Ile Lys Val Arg Arg Arg Glu Asp Gly Ala Arg Lys Pro Glu 
         275                280                285
Arg Arg Arg Leu Arg Ala Ala Arg Leu Arg Glu Tyr Ser Leu Lys Ser 
     290                295                300
His Ser Ser Met Pro Arg Asn Thr Ser Tyr Ala Ser Phe Glu Arg Phe 
 305                310                315                320
Ser Arg Val Leu Glu Asp Val Ala Ala Ala Glu Gln Gly Leu Arg Glu 
                 325                330                335
Leu Gln Arg Gly Arg Arg Gln Cys Arg Glu Arg Val Cys Ala Leu Arg 
             340                345                350
Val Ala Ala Glu Gln Arg Glu Ala Arg Cys Arg Asp Gly Ser Ala Gly 
         355                360                365
Leu Gly Arg Asp Leu Arg Arg Leu Arg Thr Glu Leu Gly Arg Thr Glu 
     370                375                380
Ala Leu Arg Thr Arg Ala Gln Glu Glu Ala Arg Ala Ala Leu Leu Gly 
 385                390                395                400
Ala Gly Gly Leu Lys Arg Arg Leu Cys Arg Leu Glu Asn Arg Tyr Asp 
                 405                410                415
Ala Leu Ala Ala Gln Val Ala Ala Glu Val Gln Phe Val Arg Asp Leu 
             420                425                430
Val Arg Ala Leu Glu Gln Glu Arg Leu Gln Ala Glu Cys Gly Val Arg 
         435                440                445



<210> 1410
<211> 2055
<212> DNA
<213> Homo sapiens
<308> AB022341
<400> 1410

gcactttcc  tggagtgga  gctgctgga  ggcggaccg  ccgccatgt  cacgttcag  60
caggaggac  tggaggacc  ttatgagat  ggggaggag  tgggcagcg  ccagtttgc  120
atcgtgcgg  agtgccggc  gaagggcac  ggcaaggag  acgcagcca  gttcatcaa  180
aagcgccgc  tgtcatcca  ccggcgtgg  gtgagccgg  aggagatcg  gcgggaggt  240
aacatcctg  gggagatcc  gcaccccaa  atcatcacc  tgcacgaca  cttcgagaa  300
aagacggac  tggtcctca  cctggagct  gtctctggc  gggagctct  tgacttcct  360
gcggagaag  agtcgctga  ggaggacga  gccacccag  tcctcaagc  gatcctgga  420
ggcgttcac  acctgcact  taagcgcat  gcacacttt  acctgaagc  ggaaaacat  480
atgctgctg  acaagaacg  gcccaaccc  cgaatcaag  tcatcgact  cggcatcgc  540
cacaagatc  aggcgggga  cgagttcaa  aacatcttc  gcaccccgg  gtttgtggc  600
ccagagatt  tgaactatg  gccgctggg  ctggaggcg  acatgtgga  catcggtgt  660
atcacctat  tcctcctga  cggtgcatc  ccgttcctg  gcgagacca  gcaggagac  720
ctcaccaac  tctcagccg  gaactacga  ttcgacgag  agtacttca  caacaccag  780
gagctggcc  aggacttca  tcgccggct  ctcgtcaaa  atcccaagc  gagaatgac  840
attgcccag  gcctggaac  ttcctggat  aaggcgatc  ggcggcgga  cgtgcgtgg  900
gaggacagc  gccgcaagc  cgagcggcg  cgcctgaag  ccacgcgtc  gaaggagta  960
accatcaag  cgcactcca  cttgccgcc  aacaacagc  acgccgact  cgagcgctt  1020
tccaaggtg  tggaggagg  ggcggccgc  gaggagggc  tgcgcgagc  gcagcgcag  1080
cggcggctc  gccacgagg  cgtggaggc  ctggccgcc  tctacgagg  gaaggaggc  1140
tggtaccgc  aggagagcg  cagcctggg  caggacctg  ggaggctac  gcaggagct  1200
ctcaagacc  aggcgctca  gcggcaggc  caggaggag  ccaagggcg  gctgctggg  1260
accagcggc  tcaagcgcc  cttcagccg  ctggagaac  gctacgagg  gctggccaa  1320
caagtagcc  ccgagatgc  cttcgtgca  gacctcgtg  gcgccctgg  gcaggagaa  1380
ctgcagggc  tggagtgcg  gctgcgcta  gcgcagtgg  gtgggccag  ccccaggac  1440
gccggagct  ggcctgcgg  gggggcgct  cctgtggac  ctgcgcctc  catcgcccg  1500
gtgcctgtc  ttgcccagc  ccaccaggc  ggaggcgga  tgggaggag  tggagccag  1560
cccgtaagt  cgcaggcag  ggtgggtgt  ggacggggc  gcttctcta  acatcctcc  1620
cgctggcct  caccttcac  cctgcatcg  cggtgaccc  gggaccctc  aggcagcgt  1680
gcctgtggc  ccgtgaggg  tgggaccca  cgaggcgca  aggcggccc  aatgcagcc  1740
tggttcagg  ccggaggag  gtttgcggg  agttgcacg  acaattcgg  ggggtgctg  1800
ctgttgctg  cattagccc  ggaggaggt  gtgggacgg  gagggtggg  tggacggcg  1860
acaggcagt  cccacgctg  tgggtggcg  cgggcttgg  ggggtcttc  actgtgtgc  1920
cttctcgcc  aggccggtc  cccgggtgt  gggtgccct  ctgcggact  ctccgcgag  1980
cccatcgtc  cgcctgtgg  cgcctaggc  agagcggcc  tctgcagcc  agagaaata  2040
aatactggc  tccag  2055



<210> 1411
<211> 454
<212> PRT
<213> Homo sapiens
<308> NP_001339
<400> 1411

Met Ser Thr Phe Arg Gln Glu Asp Val Glu Asp His Tyr Glu Met Gly 
  1               5                  10                  15
Glu Glu Leu Gly Ser Gly Gln Phe Ala Ile Val Arg Lys Cys Arg Gln 
             20                  25                  30
Lys Gly Thr Gly Lys Glu Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
         35                  40                  45
Leu Ser Ser Ser Arg Arg Gly Val Ser Arg Glu Glu Ile Glu Arg Glu 
     50                  55                  60
Val Asn Ile Leu Arg Glu Ile Arg His Pro Asn Ile Ile Thr Leu His 
 65                  70                  75                  80
Asp Ile Phe Glu Asn Lys Thr Asp Val Val Leu Ile Leu Glu Leu Val 
                 85                  90                  95
Ser Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 
             100                105                110
Glu Asp Glu Ala Thr Gln Phe Leu Lys Gln Ile Leu Asp Gly Val His 
         115                120                125
Tyr Leu His Ser Lys Arg Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
     130                135                140
Ile Met Leu Leu Asp Lys Asn Val Pro Asn Pro Arg Ile Lys Leu Ile 
 145                150                155                160
Asp Phe Gly Ile Ala His Lys Ile Glu Ala Gly Asn Glu Phe Lys Asn 
                 165                170                175
Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
             180                185                190
Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 
         195                200                205
Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Glu Thr Lys Gln Glu 
     210                215                220
Thr Leu Thr Asn Ile Ser Ala Val Asn Tyr Asp Phe Asp Glu Glu Tyr 
 225                230                235                240
Phe Ser Asn Thr Ser Glu Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                 245                250                255
Val Lys Asp Pro Lys Arg Arg Met Thr Ile Ala Gln Ser Leu Glu His 
             260                265                270
Ser Trp Ile Lys Ala Ile Arg Arg Arg Asn Val Arg Gly Glu Asp Ser 
         275                280                285
Gly Arg Lys Pro Glu Arg Arg Arg Leu Lys Thr Thr Arg Leu Lys Glu 
     290                295                300
Tyr Thr Ile Lys Ser His Ser Ser Leu Pro Pro Asn Asn Ser Tyr Ala 
 305                310                315                320
Asp Phe Glu Arg Phe Ser Lys Val Leu Glu Glu Ala Ala Ala Ala Glu 
                 325                330                335
Glu Gly Leu Arg Glu Leu Gln Arg Ser Arg Arg Leu Cys His Glu Asp 
             340                345                350
Val Glu Ala Leu Ala Ala Ile Tyr Glu Glu Lys Glu Ala Trp Tyr Arg 
         355                360                365
Glu Glu Ser Asp Ser Leu Gly Gln Asp Leu Arg Arg Leu Arg Gln Glu 
     370                375                380
Leu Leu Lys Thr Glu Ala Leu Lys Arg Gln Ala Gln Glu Glu Ala Lys 
 385                390                395                400
Gly Ala Leu Leu Gly Thr Ser Gly Leu Lys Arg Arg Phe Ser Arg Leu 
                 405                410                415
Glu Asn Arg Tyr Glu Ala Leu Ala Lys Gln Val Ala Ser Glu Met Arg 
             420                425                430
Phe Val Gln Asp Leu Val Arg Ala Leu Glu Gln Glu Lys Leu Gln Gly 
         435                440                445
Val Glu Cys Gly Leu Arg 
     450



<210> 1412
<211> 1095
<212> DNA
<213> Rattus norvegicus
<308> AJ007016
<400> 1412

aaattgcaa  cgtattctt  taatgactc  agtaaaatt  agcatcaag  aaacaaaag  60
ggaaaagaa  ctacacttt  aacttgtct  actagtgcc  aaatgtagt  taaaggctg  120
ttaaatttt  tgtgtagtt  gattttttg  aagctgaag  tatccatct  cagacattg  180
ggcccaagt  gaatttgga  tcgagtgga  tcttaacac  tctgcctgt  ctgaagaga  240
gcttcataa  gaacaagca  gttgaatag  gaagatagt  atcaataag  ggcatttag  300
ggtcttttt  atgttttct  ctgcgaaac  tttcaagat  tattgattt  tttttttca  360
tttccccac  acactcaca  acgcacgct  acacttttt  tttgccata  tgaaccgtc  420
agcccctgt  gagatctcg  acgagaaca  gcgttttct  ataactcac  acccagcca  480
tgcgactct  aacaagttc  ccgaggaac  caagaagta  ggagtgaca  ctttggtcc  540
agtttgtga  gctacctat  acaaagctc  agttgaaaa  gaagggatc  acgttctag  600
ctggccatt  gatgacgga  ctccgcccc  taatcagat  gtagatgat  ggctaaacc  660
gttaaagac  aaattccgg  aagaaccag  ctgctgtgt  gcagtgcat  gtgttgcag  720
attgggaag  gctcctgtg  tagttgcac  tgcactgat  gaatgcgga  tgaagtatg  780
agatgctgt  cagtttata  gacaaaaaa  aagaggagc  ttcaattcc  aacagctgc  840
ttacttgga  aaataccga  ctaagatgc  attacgctc  agagatacc  acgggcact  900
ctgtgttca  tagaagcag  ggaaggccg  ctggatcgt  gcattagag  gaactctgg  960
tacctggaa  tgtgaatct  gattcttac  tgtgtcatc  aagtagtga  ggattccgt  1020
ctcctcgac  cctcatgat  gagaagaag  caaacgata  agaaatccc  ctataacac  1080
aataaaatg  ttaag  1095



<210> 1413
<211> 167
<212> PRT
<213> Rattus norvegicus
<308> CAA07417
<400> 1413

Met Asn Arg Pro Ala Pro Val Glu Ile Ser Tyr Glu Asn Met Arg Phe 
  1               5                  10                  15
Leu Ile Thr His Asn Pro Ala Asn Ala Thr Leu Asn Lys Phe Thr Glu 
             20                  25                  30
Glu Leu Lys Lys Tyr Gly Val Thr Thr Leu Val Arg Val Cys Asp Ala 
         35                  40                  45
Thr Tyr Asp Lys Ala Pro Val Glu Lys Glu Gly Ile His Val Leu Asp 
     50                  55                  60
Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Asn Gln Ile Val Asp Asp 
 65                  70                  75                  80
Trp Leu Asn Leu Leu Lys Thr Lys Phe Arg Glu Glu Pro Gly Cys Cys 
                 85                  90                  95
Val Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro Val Leu Val 
             100                105                110
Ala Leu Ala Leu Ile Glu Cys Gly Met Lys Tyr Glu Asp Ala Val Gln 
         115                120                125
Phe Ile Arg Gln Lys Arg Arg Gly Ala Phe Asn Ser Lys Gln Leu Leu 
     130                135                140
Tyr Leu Glu Lys Tyr Arg Pro Lys Met Arg Leu Arg Ser Arg Asp Thr 
 145                150                155                160
Asn Gly His Cys Cys Val Gln 
                 165



<210> 1414
<211> 439
<212> DNA
<213> Homo sapiens
<308> AI816111
<400> 1414

gctggagcg  cagcggcgg  cgggcacgg  gcgaggtga  gccgccgcc  ccgccgccg  60
ggtgactga  gagagaggc  cctcctcgc  cccgccacc  ccggacttc  atgcccagt  120
cccagctcg  cagcgtttt  cgttggaat  tacgttgca  atttatggc  attctgagt  180
tgagggcag  cttctgcca  gctcagcac  gcattttcg  tgacaagtg  gcttggagg  240
tctatgtgc  ataattaac  ttgccttga  gactcctgg  caccgagac  ggcctcaga  300
atagttggc  ttttttttt  ttaattgca  gcatatttc  tttaatgac  ccagtaaaa  360
taagcatca  gtaaacaag  ggaaagtga  ctacacttt  aacttgtct  actagtgcc  420
aaatgtagt  aaggcttgc  439



<210> 1415
<211> 167
<212> PRT
<213> Homo sapiens
<308> NP_003470
<400> 1415

Met Asn Arg Pro Ala Pro Val Glu Ile Ser Tyr Glu Asn Met Arg Phe 
  1               5                  10                  15
Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Asn Lys Phe Thr Glu 
             20                  25                  30
Glu Leu Lys Lys Tyr Gly Val Thr Thr Leu Val Arg Val Cys Asp Ala 
         35                  40                  45
Thr Tyr Asp Lys Ala Pro Val Glu Lys Glu Gly Ile His Val Leu Asp 
     50                  55                  60
Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Asn Gln Ile Val Asp Asp 
 65                  70                  75                  80
Trp Leu Asn Leu Leu Lys Thr Lys Phe Arg Glu Glu Pro Gly Cys Cys 
                 85                  90                  95
Val Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro Val Leu Val 
             100                105                110
Ala Leu Ala Leu Ile Glu Cys Gly Met Lys Tyr Glu Asp Ala Val Gln 
         115                120                125
Phe Ile Arg Gln Lys Arg Arg Gly Ala Phe Asn Ser Lys Gln Leu Leu 
     130                135                140
Tyr Leu Glu Lys Tyr Arg Pro Lys Met Arg Leu Arg Phe Arg Asp Thr 
 145                150                155                160
Asn Gly His Cys Cys Val Gln 
                 165



<210> 1416
<211> 1077
<212> DNA
<213> Rattus norvegicus
<308> AJ007291
<400> 1416

tccgccaaa  ttttgatgc  tgggaaccg  gcaggaaaa  cacgcggaa  gtgcttcac  60
gtggcggct  actgctctc  ttcgcggtg  agagccgtc  ggcagggtt  acctcctaa  120
gggatattc  atctttatt  attccagac  tttcagcag  ttatcggaa  agcaacaac  180
gcaacaaaa  cttcaaaat  tacaagtct  taagaaata  aaatggcat  caaaagagc  240
ctggtcatc  tagccaaag  agcagagga  atggagaca  tgattcctg  ggacatcat  300
cggcgagct  ggattaaag  caccgttgc  ggcttggct  ggaaggacc  cgtgcagtg  360
agccgtgat  tagtgattt  tccggatac  agtctggaa  aagcaaaaa  acagggacc  420
tacgatgtg  ttgttcttc  aggaggaaa  ctgggtgca  agaacttat  tgagtcggc  480
ttggtgaag  agatcctca  ggagcagga  aacaggaag  gcctcatag  tgccatctg  540
gcgggtcct  cggccctgc  ggctcacga  gtaggcttt  gatgcaagg  tacatcgca  600
ccattggct  aggacaaaa  gatgaacgg  agtcactac  gctactcag  gagccgtgt  660
gaaaaggac  gcctcatcc  caccagccg  gggcctggg  ccagcttcg  gtttgcgct  720
gccattgtg  aggcactca  tggcaagga  atggctaac  aagtgaagg  cccacttgt  780
ctcaaagac  agagcccaa  ccctagacc  tggaccccc  ggctgagca  gcattggaa  840
cccactagt  tgtccacag  ccagtgaac  tcaggaact  acgtgtgaa  tagcccgct  900
ctcaggaat  tcgccctgg  tctgtacta  tctgagcct  gctagtaga  taaacagtt  960
cccaagcgg  attcccaaa  aaaaagact  ggtatttgt  ggctgttga  ttcactgca  1020
cctcaggca  ctcatcaat  cgggccggc  aatgtgggt  tcccttcat  gtcgcga  1077



<210> 1417
<211> 189
<212> PRT
<213> Rattus norvegicus
<308> CAA07434
<400> 1417

Met Ala Ser Lys Arg Ala Leu Val Ile Leu Ala Lys Gly Ala Glu Glu 
  1               5                  10                  15
Met Glu Thr Val Ile Pro Val Asp Ile Met Arg Arg Ala Gly Ile Lys 
             20                  25                  30
Val Thr Val Ala Gly Leu Ala Gly Lys Asp Pro Val Gln Cys Ser Arg 
         35                  40                  45
Asp Val Val Ile Cys Pro Asp Thr Ser Leu Glu Glu Ala Lys Thr Gln 
     50                  55                  60
Gly Pro Tyr Asp Val Val Val Leu Pro Gly Gly Asn Leu Gly Ala Gln 
 65                  70                  75                  80
Asn Leu Ser Glu Ser Ala Leu Val Lys Glu Ile Leu Lys Glu Gln Glu 
                 85                  90                  95
Asn Arg Lys Gly Leu Ile Ala Ala Ile Cys Ala Gly Pro Thr Ala Leu 
             100                105                110
Leu Ala His Glu Val Gly Phe Gly Cys Lys Val Thr Ser His Pro Leu 
         115                120                125
Ala Lys Asp Lys Met Met Asn Gly Ser His Tyr Ser Tyr Ser Glu Ser 
     130                135                140
Arg Val Glu Lys Asp Gly Leu Ile Leu Thr Ser Arg Gly Pro Gly Thr 
 145                150                155                160
Ser Phe Glu Phe Ala Leu Ala Ile Val Glu Ala Leu Ser Gly Lys Asp 
                 165                170                175
Met Ala Asn Gln Val Lys Ala Pro Leu Val Leu Lys Asp 
             180                185



<210> 1418
<211> 1077
<212> DNA
<213> Rattus norvegicus
<308> AJ007291
<400> 1418

tccgccaaa  ttttgatgc  tgggaaccg  gcaggaaaa  cacgcggaa  gtgcttcac  60
gtggcggct  actgctctc  ttcgcggtg  agagccgtc  ggcagggtt  acctcctaa  120
gggatattc  atctttatt  attccagac  tttcagcag  ttatcggaa  agcaacaac  180
gcaacaaaa  cttcaaaat  tacaagtct  taagaaata  aaatggcat  caaaagagc  240
ctggtcatc  tagccaaag  agcagagga  atggagaca  tgattcctg  ggacatcat  300
cggcgagct  ggattaaag  caccgttgc  ggcttggct  ggaaggacc  cgtgcagtg  360
agccgtgat  tagtgattt  tccggatac  agtctggaa  aagcaaaaa  acagggacc  420
tacgatgtg  ttgttcttc  aggaggaaa  ctgggtgca  agaacttat  tgagtcggc  480
ttggtgaag  agatcctca  ggagcagga  aacaggaag  gcctcatag  tgccatctg  540
gcgggtcct  cggccctgc  ggctcacga  gtaggcttt  gatgcaagg  tacatcgca  600
ccattggct  aggacaaaa  gatgaacgg  agtcactac  gctactcag  gagccgtgt  660
gaaaaggac  gcctcatcc  caccagccg  gggcctggg  ccagcttcg  gtttgcgct  720
gccattgtg  aggcactca  tggcaagga  atggctaac  aagtgaagg  cccacttgt  780
ctcaaagac  agagcccaa  ccctagacc  tggaccccc  ggctgagca  gcattggaa  840
cccactagt  tgtccacag  ccagtgaac  tcaggaact  acgtgtgaa  tagcccgct  900
ctcaggaat  tcgccctgg  tctgtacta  tctgagcct  gctagtaga  taaacagtt  960
cccaagcgg  attcccaaa  aaaaagact  ggtatttgt  ggctgttga  ttcactgca  1020
cctcaggca  ctcatcaat  cgggccggc  aatgtgggt  tcccttcat  gtcgcga  1077



<210> 1419
<211> 189
<212> PRT
<213> Rattus norvegicus
<308> CAA07434
<400> 1419

Met Ala Ser Lys Arg Ala Leu Val Ile Leu Ala Lys Gly Ala Glu Glu 
  1               5                  10                  15
Met Glu Thr Val Ile Pro Val Asp Ile Met Arg Arg Ala Gly Ile Lys 
             20                  25                  30
Val Thr Val Ala Gly Leu Ala Gly Lys Asp Pro Val Gln Cys Ser Arg 
         35                  40                  45
Asp Val Val Ile Cys Pro Asp Thr Ser Leu Glu Glu Ala Lys Thr Gln 
     50                  55                  60
Gly Pro Tyr Asp Val Val Val Leu Pro Gly Gly Asn Leu Gly Ala Gln 
 65                  70                  75                  80
Asn Leu Ser Glu Ser Ala Leu Val Lys Glu Ile Leu Lys Glu Gln Glu 
                 85                  90                  95
Asn Arg Lys Gly Leu Ile Ala Ala Ile Cys Ala Gly Pro Thr Ala Leu 
             100                105                110
Leu Ala His Glu Val Gly Phe Gly Cys Lys Val Thr Ser His Pro Leu 
         115                120                125
Ala Lys Asp Lys Met Met Asn Gly Ser His Tyr Ser Tyr Ser Glu Ser 
     130                135                140
Arg Val Glu Lys Asp Gly Leu Ile Leu Thr Ser Arg Gly Pro Gly Thr 
 145                150                155                160
Ser Phe Glu Phe Ala Leu Ala Ile Val Glu Ala Leu Ser Gly Lys Asp 
                 165                170                175
Met Ala Asn Gln Val Lys Ala Pro Leu Val Leu Lys Asp 
             180                185



<210> 1420
<211> 3595
<212> DNA
<213> Rattus norvegicus
<308> AJ007627
<400> 1420

ggcggtccc  gccgcctaa  atgccggcc  tgcgggggc  ccttgcgcc  cagaacacc  60
tcctggaca  catcgccac  cgcttcgac  ggacgcaca  taacttcgt  ctgggcaac  120
cccaggtgg  agggctctt  cctgtggtc  actgctccg  tggcttctg  gacctcacg  180
gtttctcca  agctgaggt  atgcagcga  gctgtgcct  ctccttcct  tatgggcca  240
acaccagtg  gttggtccg  caacagatc  gaaaagccc  ggatgagca  aaagaattc  300
aggctgaac  gatcctgta  cggaagagc  ggcttccat  ctggtgtct  ctggatgtg  360
tacctataa  aaacgagaa  ggggaggtg  ccctcttcc  ggtctctca  aaggacatc  420
gtgagacca  gaaccgagg  ggccctgac  actggaagg  gagaggtgg  ggccgacgc  480
gatatggtc  ggcaggatc  aaaggcttt  atgccaatc  gaggcgcag  cgggcggtt  540
tctaccacc  ctctggtca  ctgcagaaa  aacccaagg  caagcacaa  ctcaataag  600
gtgtgtttg  agagaagcc  aatttgccc  aatataaag  cgctgctat  cggaagtca  660
cctttatcc  gctgcactg  ggggctctg  gagccacct  ggatggctt  atcctgctc  720
ccacgctct  cgtggctgt  actgtgcca  acagcgtgt  tgtgagcac  gcacgggag  780
ccagtgctg  ccgtggccc  cctagtgtc  gtgacctgg  cgtggaagt  ctcttcatc  840
tagatattg  gctgaattt  cgtactaca  ttgtgtcca  gtcaggcca  gtggtattc  900
ccccaaagt  catttgcct  cactacgtc  ccacctggt  cctgctgga  gtcatagca  960
cactgccct  tgacctact  catgccttc  aggtcaatg  gtacgttgg  gctcaccta  1020
tgaagaccg  gcggctgct  cggctgctg  gcctactac  aagactgga  cggtactct  1080
agtatagcg  tgttgtgct  accttgctc  tggctgtgt  tgccctgct  gcccactgg  1140
tggcctgcg  ttggttcta  atcggccag  aagagattg  gaacagcga  tcagagctg  1200
ctgagatcg  ctggctgca  gagctggca  gcaggctgg  gacgcccta  tacctggtg  1260
gccggagtc  agatggagg  aacagctct  gccagagtg  aaactgcag  agcagtggc  1320
gcggcagcg  agccaacgg  actgggctg  agctgctgg  tggcccatc  ctacgcagc  1380
cctacatca  ctccttgta  ttcgcgctc  gcagtctca  cagtgtggg  ttcggcaat  1440
tgtccgcta  cacagacac  gagaagatt  tctccatct  caccatgct  attggagct  1500
tgatgcatg  agtggtgtt  gggaatgtg  cagccatca  ccagcgcat  tacgctcgc  1560
gctttctgt  ccacagccg  acccgtgac  tgcgagact  cattcgcat  caccgcatc  1620
ccaagcccc  caagcagcg  atgctcgag  acttccaag  cacctgggc  gtgaacaac  1680
gcatcgata  cactgagct  ctgcagagc  ttccggatg  gcttcgagc  gacatcgcc  1740
tgcacctgc  caaggaggt  ctgcagctg  cattgttcg  ggcagcgag  cgtggctgc  1800
tgcgggcac  gtctctggc  ctgaggccc  ccttctgca  gccgggcga  tacctcatt  1860
accaaggcg  tgctctcca  gctctctac  ttgtgtgct  aggttccat  gaggtcctc  1920
aaggtggca  cgtcctcgc  attctaggg  agggtgacc  gatcggctg  gagctgccc  1980
agcgagagc  agtagtgaa  gccaatgcc  acgtaaagg  gctgacata  tgcgtccta  2040
agtgcctgc  gctggctgg  ctgcacgag  gcctcgcac  gtaccctga  tttgcccca  2100
gctttagcc  tggcctccg  ggggagctc  gctacaacc  gggagctgg  ggagtgtct  2160
cagaggtgg  taccagctc  ctgagtggt  acaacaccc  catgtccac  ctggaggag  2220
aggagacag  tggggagca  ggacacacg  tctcaccag  cccagcaga  gagccctcc  2280
gccccctgc  gtcacctgg  tgtacctcc  cctcctcag  ggccaaact  ctctcccca  2340
gtcgaactg  accccggcc  aggctgggt  gcagagggc  gccaagtag  gcaggggtt  2400
tgaagcctg  ggctggtcc  tctgctcat  cacggacac  tgatgggtt  cagctgccc  2460
ccatgccat  gaatgtacc  ccagacctg  gccccaggg  cgtagatgg  attgaggat  2520
gctgcggct  tgaccagca  aagttctct  tccgggtgg  tcagtctgg  ccagaatgt  2580
gcagcagcc  ctccccagg  acagagagt  gcctgctca  tgtcccctt  gtgcccagt  2640
aggcaagaa  cacagacac  ctggacaag  tacggcagg  ggtgacgga  ctgtctgaa  2700
aggtgctgc  gatgcgaga  ggactgcag  cacttcgcc  ggctgtgca  ctcatcctg  2760
tgccccaag  ggaaggcca  tgtccccgg  tatcaggag  ggggccatg  ccagccact  2820
cctctgggc  cctacaacc  ctgcgtgtg  acactgggg  atcatccta  tgcctgcag  2880
ccccagcag  ttcagtctt  agtgggacc  ggcctcacc  ccgtccagg  catccccct  2940
ccctcatgg  accctggcc  tggggcccc  cagcatctc  gagctcccc  tggcctcga  3000
ccacagctt  atggacctc  acctcagac  cagagcccc  tggctctgg  gacctctgc  3060
ctgagccca  caccccagc  tcaccccct  ctcctgagg  aggagctag  actgggact  3120
ctgcacctg  gagccaggc  gaggctacc  gtactggag  gccccctcc  gggtcaggg  3180
gccgagcct  gccctggga  ccccacagc  tagagatgg  gctcatcgg  tgccatggc  3240
ctggctcgg  ccagtggac  caggaggag  gcacaggag  ctgaccaca  gcagggaga  3300
gggttctgc  aacacccgc  acctgctga  cgcccagcc  cacagggct  ccctctggc  3360
cagggcagg  aacctaagg  aggaggagg  tgagctgga  cctcaggcc  aggagggat  3420
cacgggttc  gctccactg  cctgaccca  tgggggcag  ggcctgagg  cgaggaggg  3480
ttctgccat  ccttgcatg  gcccatctc  actgtcctc  gtcctcatg  tttttatat  3540
aaaaaacat  aaaaaaaac  aataaagaa  ctaccttgg  aaaaaaaaa  aaaaa  3595



<210> 1421
<211> 1087
<212> PRT
<213> Rattus norvegicus
<308> CAA07586
<400> 1421

Met Pro Ala Met Arg Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp 
  1               5                  10                  15
Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Val Leu Gly 
             20                  25                  30
Asn Ala Gln Val Ala Gly Leu Phe Pro Val Val Tyr Cys Ser Asp Gly 
         35                  40                  45
Phe Cys Asp Leu Thr Gly Phe Ser Arg Ala Glu Val Met Gln Arg Gly 
     50                  55                  60
Cys Ala Cys Ser Phe Leu Tyr Gly Pro Asp Thr Ser Glu Leu Val Arg 
 65                  70                  75                  80
Gln Gln Ile Arg Lys Ala Leu Asp Glu His Lys Glu Phe Lys Ala Glu 
                 85                  90                  95
Leu Ile Leu Tyr Arg Lys Ser Gly Leu Pro Phe Trp Cys Leu Leu Asp 
             100                105                110
Val Ile Pro Ile Lys Asn Glu Lys Gly Glu Val Ala Leu Phe Leu Val 
         115                120                125
Ser His Lys Asp Ile Ser Glu Thr Lys Asn Arg Gly Gly Pro Asp Asn 
     130                135                140
Trp Lys Glu Arg Gly Gly Gly Arg Arg Arg Tyr Gly Arg Ala Gly Ser 
 145                150                155                160
Lys Gly Phe Asn Ala Asn Arg Arg Arg Ser Arg Ala Val Leu Tyr His 
                 165                170                175
Leu Ser Gly His Leu Gln Lys Gln Pro Lys Gly Lys His Lys Leu Asn 
             180                185                190
Lys Gly Val Phe Gly Glu Lys Pro Asn Leu Pro Glu Tyr Lys Val Ala 
         195                200                205
Ala Ile Arg Lys Ser Pro Phe Ile Leu Leu His Cys Gly Ala Leu Arg 
     210                215                220
Ala Thr Trp Asp Gly Phe Ile Leu Leu Ala Thr Leu Tyr Val Ala Val 
 225                230                235                240
Thr Val Pro Tyr Ser Val Cys Val Ser Thr Ala Arg Glu Pro Ser Ala 
                 245                250                255
Ala Arg Gly Pro Pro Ser Val Cys Asp Leu Ala Val Glu Val Leu Phe 
             260                265                270
Ile Leu Asp Ile Val Leu Asn Phe Arg Thr Thr Phe Val Ser Lys Ser 
         275                280                285
Gly Gln Val Val Phe Ala Pro Lys Ser Ile Cys Leu His Tyr Val Thr 
     290                295                300
Thr Trp Phe Leu Leu Asp Val Ile Ala Ala Leu Pro Phe Asp Leu Leu 
 305                310                315                320
His Ala Phe Lys Val Asn Val Tyr Val Gly Ala His Leu Leu Lys Thr 
                 325                330                335
Val Arg Leu Leu Arg Leu Leu Arg Leu Leu Pro Arg Leu Asp Arg Tyr 
             340                345                350
Ser Gln Tyr Ser Ala Val Val Leu Thr Leu Leu Met Ala Val Phe Ala 
         355                360                365
Leu Leu Ala His Trp Val Ala Cys Val Trp Phe Tyr Ile Gly Gln Gln 
     370                375                380
Glu Ile Glu Asn Ser Glu Ser Glu Leu Pro Glu Ile Gly Trp Leu Gln 
 385                390                395                400
Glu Leu Ala Arg Arg Leu Glu Thr Pro Tyr Tyr Leu Val Ser Arg Ser 
                 405                410                415
Pro Asp Gly Gly Asn Ser Ser Gly Gln Ser Glu Asn Cys Ser Ser Ser 
             420                425                430
Gly Gly Gly Ser Glu Ala Asn Gly Thr Gly Leu Glu Leu Leu Gly Gly 
         435                440                445
Pro Ser Leu Arg Ser Ala Tyr Ile Thr Ser Leu Tyr Phe Ala Leu Ser 
     450                455                460
Ser Leu Thr Ser Val Gly Phe Gly Asn Val Ser Ala Asn Thr Asp Thr 
 465                470                475                480
Glu Lys Ile Phe Ser Ile Cys Thr Met Leu Ile Gly Ala Leu Met His 
                 485                490                495
Ala Val Val Phe Gly Asn Val Thr Ala Ile Ile Gln Arg Met Tyr Ala 
             500                505                510
Arg Arg Phe Leu Tyr His Ser Arg Thr Arg Asp Leu Arg Asp Tyr Ile 
         515                520                525
Arg Ile His Arg Ile Pro Lys Pro Leu Lys Gln Arg Met Leu Glu Tyr 
     530                535                540
Phe Gln Ala Thr Trp Ala Val Asn Asn Gly Ile Asp Thr Thr Glu Leu 
 545                550                555                560
Leu Gln Ser Leu Pro Asp Glu Leu Arg Ala Asp Ile Ala Met His Leu 
                 565                570                575
His Lys Glu Val Leu Gln Leu Pro Leu Phe Glu Ala Ala Ser Arg Gly 
             580                585                590
Cys Leu Arg Ala Leu Ser Leu Ala Leu Arg Pro Ala Phe Cys Thr Pro 
         595                600                605
Gly Glu Tyr Leu Ile His Gln Gly Asp Ala Leu Gln Ala Leu Tyr Phe 
     610                615                620
Val Cys Ser Gly Ser Met Glu Val Leu Lys Gly Gly Thr Val Leu Ala 
 625                630                635                640
Ile Leu Gly Lys Gly Asp Leu Ile Gly Cys Glu Leu Pro Gln Arg Glu 
                 645                650                655
Gln Val Val Lys Ala Asn Ala Asp Val Lys Gly Leu Thr Tyr Cys Val 
             660                665                670
Leu Gln Cys Leu Gln Leu Ala Gly Leu His Glu Ser Leu Ala Leu Tyr 
         675                680                685
Pro Glu Phe Ala Pro Arg Phe Ser Arg Gly Leu Arg Gly Glu Leu Ser 
     690                695                700
Tyr Asn Leu Gly Ala Gly Gly Val Ser Ala Glu Val Asp Thr Ser Ser 
 705                710                715                720
Leu Ser Gly Asp Asn Thr Leu Met Ser Thr Leu Glu Glu Lys Glu Thr 
                 725                730                735
Asp Gly Glu Gln Gly His Thr Ile Ser Pro Ala Pro Ala Asp Glu Pro 
             740                745                750
Ser Ser Pro Leu Leu Ser Pro Gly Cys Thr Ser Ser Ser Ser Ala Ala 
         755                760                765
Lys Leu Leu Ser Pro Arg Arg Thr Ala Pro Arg Pro Arg Leu Gly Gly 
     770                775                780
Arg Gly Arg Pro Ser Arg Ala Gly Val Leu Lys Pro Glu Ala Gly Pro 
 785                790                795                800
Ser Ala His Pro Arg Thr Leu Asp Gly Leu Gln Leu Pro Pro Met Pro 
                 805                810                815
Trp Asn Val Pro Pro Asp Leu Ser Pro Arg Val Val Asp Gly Ile Glu 
             820                825                830
Asp Gly Cys Gly Ser Asp Gln His Lys Phe Ser Phe Arg Val Gly Gln 
         835                840                845
Ser Gly Pro Glu Cys Ser Ser Ser Pro Ser Pro Gly Thr Glu Ser Gly 
     850                855                860
Leu Leu Thr Val Pro Leu Val Pro Ser Glu Ala Arg Asn Thr Asp Thr 
 865                870                875                880
Leu Asp Lys Leu Arg Gln Ala Val Thr Glu Leu Ser Glu Gln Val Leu 
                 885                890                895
Gln Met Arg Glu Gly Leu Gln Ser Leu Arg Gln Ala Val Gln Leu Ile 
             900                905                910
Leu Val Pro Gln Gly Glu Gly Gln Cys Pro Arg Val Ser Gly Glu Gly 
         915                920                925
Pro Cys Pro Ala Thr Ala Ser Gly Leu Leu Gln Pro Leu Arg Val Asp 
     930                935                940
Thr Gly Ala Ser Ser Tyr Cys Leu Gln Pro Pro Ala Gly Ser Val Leu 
 945                950                955                960
Ser Gly Thr Trp Pro His Pro Arg Pro Gly His Pro Pro Pro Leu Met 
                 965                970                975
Ala Pro Trp Pro Trp Gly Pro Pro Ala Ser Gln Ser Ser Pro Trp Pro 
             980                985                990
Arg Ala Thr Ala Leu Trp Thr Ser Thr Ser Asp Ser Glu Pro Pro Gly 
         995                1000                1005
Ser Gly Asp Leu Cys Ser Glu Pro Ser Thr Pro Ala Ser Pro Pro Pro 
     1010                1015                1020
Pro Glu Glu Gly Ala Arg Thr Gly Thr Pro Ala Pro Val Ser Gln Ala 
 1025                1030                1035                1040
Glu Ala Thr Ser Thr Gly Glu Pro Pro Pro Gly Ser Gly Gly Arg Ala 
                 1045                1050                1055
Leu Pro Trp Asp Pro His Ser Leu Glu Met Val Leu Ile Gly Cys His 
             1060                1065                1070
Gly Pro Gly Ser Val Gln Trp Thr Gln Glu Glu Gly Thr Gly Val 
         1075                1080                1085



<210> 1422
<211> 3853
<212> DNA
<213> Homo sapiens
<308> AB033108
<400> 1422

ggccgcggg  cctggagcc  gggatttgt  ggcggcgag  gcgcgaggg  ccgcgcgcc  60
tgctccggg  cccgacggc  cggacgccc  ctcgcgcgc  agcgtccgg  gcgaccccg  120
atcccggtc  gcgcattgc  ccccgacgg  tgcgctagg  agcgcgggg  ccggcgggg  180
gcggccgag  tgggcgccc  cccccggcg  ggagtcccc  caccccgga  ggatggggc  240
ggcagccgc  ggcgcctaa  atgccggcc  tgcggggcc  cctggcgcc  cagaacacc  300
tcctggaca  catcgctac  cgcttcgac  gcacgcaca  taacttcgt  ctgggcaac  360
cccaggtgg  ggggctctt  cccgtggtc  actgctctg  tggcttctg  gacctcacg  420
gcttctccc  ggctgaggt  atgcagcgg  gctgtgcct  ctccttcct  tatgggcca  480
acaccagtg  gctcgtccg  caacagatc  gcaaggccc  ggacgagca  aaggagttc  540
aggctgagc  gatcctgta  cggaagagc  ggctcccgt  ctggtgtct  ctggatgtg  600
tacccataa  gaatgagaa  ggggaggtg  ctctcttcc  agtctctca  aaggacatc  660
gcgaaacca  gaaccgagg  ggccccgac  gatggaagg  gacaggtgg  ggccggcgc  720
gatatggcc  ggcacgatc  aaaggcttc  atgccaacc  gcggcggag  cgggccgtg  780
tctaccacc  gtccgggca  ctgcagaag  agcccaagg  caagcacaa  ctcaataag  840
gggtgtttg  ggagaaacc  aacttgcct  agtacaaag  agccgccat  cggaagtcg  900
ccttcatcc  gttgcactg  ggggcactg  gagccacct  ggatggctt  atcctgctc  960
ccacactct  tgtggctgt  actgtgccc  acagcgtgt  tgtgagcac  gcacgggag  1020
ccagtgccg  ccgcggccc  cccagcgtc  gtgacctgg  cgtggaggt  ctcttcatc  1080
ttgacattg  gctgaattt  cgtaccaca  tcgtgtcca  gtcgggcca  gtggtgttt  1140
ccccaaagt  catttgcct  cactacgtc  ccacctggt  cctgctgga  gtcatcgca  1200
cgctgccct  tgacctgct  catgccttc  aggtcaacg  gtacttcgg  gcccatctg  1260
tgaagacgg  gcgcctgct  cgcctgctg  gcctgcttc  gcggctgga  cggtactcg  1320
agtacagcg  cgtggtgct  acactgctc  tggccgtgt  cgccctgct  gcgcactgg  1380
tcgcctgcg  ctggtttta  attggccag  gggagatcg  gagcagcga  tccgagctg  1440
ctgagattg  ctggctgca  gagctggcc  gccgactgg  gactcccta  tacctggtg  1500
gccggaggc  agctggagg  aacagctcc  gccagagtg  caactgcag  agcagcagc  1560
aggccaacg  gacggggct  gagctgctg  gcggcccgt  gctgcgcag  gcctacatc  1620
cctccctct  cttcgcact  agcagcctc  ccagcgtgg  cttcggcaa  gtgtccgcc  1680
acacggaca  cgagaagat  ttctccatc  gcaccatgc  catcggcgc  ctgatgcac  1740
cggtggtgt  tgggaacgt  acggccatc  tccagcgca  gtacgcccg  cgctttctg  1800
accacagcc  cacgcgcga  ctgcgcgac  acatccgca  ccaccgtat  cccaagccc  1860
tcaagcagc  catgctgga  tacttccag  ccacctggg  ggtgaacaa  ggcatcgac  1920
ccaccgagc  gctgcagag  ctccctgac  agctgcgcg  agacatcgc  atgcacctg  1980
acaaggagg  cctgcagct  ccactgttt  aggcggcca  ccgcggctg  ctgcgggca  2040
tgtctctgg  cctgcggcc  gccttctgc  cgccgggcg  gtacctcat  caccaaggc  2100
atgccctgc  ggccctcta  tttgtctgc  ctggctcca  ggaggtgct  aagggtggc  2160
ccgtgctcg  catcctagg  aagggcgac  tgatcggct  tgagctgcc  cggcgggag  2220
aggtggtaa  ggccaatgc  gacgtgaag  ggctgacgt  ctgcgtcct  cagtgtctg  2280
agctggctg  cctgcacga  agccttgcg  tgtaccccg  gtttgcccc  cgcttcagt  2340
gtggcctcc  aggggagct  agctacaac  tgggtgctg  gggaggctc  gcagaggtg  2400
acaccagct  cctgagcgg  gacaatacc  ttatgtcca  gctggagga  aaggagaca  2460
atggggagc  gggccccac  gtctcccca  ccccagctg  tgagccctc  agccccctg  2520
tgtcccctg  ctgcacctc  tcatcctca  ctgccaagc  gctatcccc  cgtcgaaca  2580
caccccggc  tcgtctagg  ggcagaggg  ggccaggca  ggcaggggc  ttgaaggct  2640
aggctggcc  ctctgctcc  ccacgggcc  tagaggggc  acggctgcc  cccatgcca  2700
ggaatgtgc  cccagatct  agccccagg  tagtagatg  cattgaaga  ggctgtggc  2760
cggaccagc  caagttctc  ttccgcgtg  gccagtctg  cccggaatg  agcagcagc  2820
cctcccctg  accagagag  ggcctgctc  ctgttcccc  tgggcccag  gaggcaagg  2880
acacagaca  actggacaa  cttcggcag  cggtgacag  gctgtcaga  caggtgctg  2940
agatgcggg  aggactgca  tcacttcgc  aggctgtgc  gcttgtcct  gcgccccac  3000
gggagggtc  gtgccctcg  gcatcggga  aggggccgt  cccagccag  acctccggg  3060
ttctgcagc  tctgtgtgt  gacactggg  catcctcct  ctgcctgca  cccccagct  3120
gctctgtct  gagtgggac  tggccccac  ctcgtccgg  gcctcctcc  ctcatggca  3180
cctggccct  gggtccccc  gcgtctcag  gctccccct  gcctcgagc  acagctttc  3240
ggacctcca  ctcagactc  gagccccct  cctcaggag  cctctgctc  gagcccagc  3300
cccctgcct  ccctcctcc  tctgaggaa  gggctagga  tgggcccgc  gagcctgtg  3360
gccaggctg  ggctaccag  actggagag  ccccaccag  gtcaggggg  ctggccttg  3420
cctgggacc  ccacagcct  gagatggtg  ttattggct  ccatggctc  ggcacagtc  3480
agtggaccc  ggaagaagg  acaggggtc  gagtaccag  cctagaact  agcgttgcc  3540
ggtgtgctg  catctgctg  tcggcccaa  ctcagagtg  aggcagggt  gcagcctcc  3600
cacggactc  atgcggccc  ctggctcag  gcagggagc  tggaagcaa  ggaggacct  3660
gctcctgac  ctcagagag  ataggctgg  tccctgggg  aggcctctc  tcggcctgc  3720
cctctgacc  cccggtctc  ctctgcagg  tgggggcag  ggcctgagg  caaggaaga  3780
ctttgccat  ccctgcatg  gcccctgcc  ctacctgtc  ccaaatttt  atattaaaa  3840
aaaaaaata  aat  3853



<210> 1423
<211> 1083
<212> PRT
<213> Homo sapiens
<308> XP_035483
<400> 1423

Met Pro Ala Met Arg Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp 
  1               5                  10                  15
Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Val Leu Gly 
             20                  25                  30
Asn Ala Gln Val Ala Gly Leu Phe Pro Val Val Tyr Cys Ser Asp Gly 
         35                  40                  45
Phe Cys Asp Leu Thr Gly Phe Ser Arg Ala Glu Val Met Gln Arg Gly 
     50                  55                  60
Cys Ala Cys Ser Phe Leu Tyr Gly Pro Asp Thr Ser Glu Leu Val Arg 
 65                  70                  75                  80
Gln Gln Ile Arg Lys Ala Leu Asp Glu His Lys Glu Phe Lys Ala Glu 
                 85                  90                  95
Leu Ile Leu Tyr Arg Lys Ser Gly Leu Pro Phe Trp Cys Leu Leu Asp 
             100                105                110
Val Ile Pro Ile Lys Asn Glu Lys Gly Glu Val Ala Leu Phe Leu Val 
         115                120                125
Ser His Lys Asp Ile Ser Glu Thr Lys Asn Arg Gly Gly Pro Asp Arg 
     130                135                140
Trp Lys Glu Thr Gly Gly Gly Arg Arg Arg Tyr Gly Arg Ala Arg Ser 
 145                150                155                160
Lys Gly Phe Asn Ala Asn Arg Arg Arg Ser Arg Ala Val Leu Tyr His 
                 165                170                175
Leu Ser Gly His Leu Gln Lys Gln Pro Lys Gly Lys His Lys Leu Asn 
             180                185                190
Lys Gly Val Phe Gly Glu Lys Pro Asn Leu Pro Glu Tyr Lys Val Ala 
         195                200                205
Ala Ile Arg Lys Ser Pro Phe Ile Leu Leu His Cys Gly Ala Leu Arg 
     210                215                220
Ala Thr Trp Asp Gly Phe Ile Leu Leu Ala Thr Leu Tyr Val Ala Val 
 225                230                235                240
Thr Val Pro Tyr Ser Val Cys Val Ser Thr Ala Arg Glu Pro Ser Ala 
                 245                250                255
Ala Arg Gly Pro Pro Ser Val Cys Asp Leu Ala Val Glu Val Leu Phe 
             260                265                270
Ile Leu Asp Ile Val Leu Asn Phe Arg Thr Thr Phe Val Ser Lys Ser 
         275                280                285
Gly Gln Val Val Phe Ala Pro Lys Ser Ile Cys Leu His Tyr Val Thr 
     290                295                300
Thr Trp Phe Leu Leu Asp Val Ile Ala Ala Leu Pro Phe Asp Leu Leu 
 305                310                315                320
His Ala Phe Lys Val Asn Val Tyr Phe Gly Ala His Leu Leu Lys Thr 
                 325                330                335
Val Arg Leu Leu Arg Leu Leu Arg Leu Leu Pro Arg Leu Asp Arg Tyr 
             340                345                350
Ser Gln Tyr Ser Ala Val Val Leu Thr Leu Leu Met Ala Val Phe Ala 
         355                360                365
Leu Leu Ala His Trp Val Ala Cys Val Trp Phe Tyr Ile Gly Gln Arg 
     370                375                380
Glu Ile Glu Ser Ser Glu Ser Glu Leu Pro Glu Ile Gly Trp Leu Gln 
 385                390                395                400
Glu Leu Ala Arg Arg Leu Glu Thr Pro Tyr Tyr Leu Val Gly Arg Arg 
                 405                410                415
Pro Ala Gly Gly Asn Ser Ser Gly Gln Ser Asp Asn Cys Ser Ser Ser 
             420                425                430
Ser Glu Ala Asn Gly Thr Gly Leu Glu Leu Leu Gly Gly Pro Ser Leu 
         435                440                445
Arg Ser Ala Tyr Ile Thr Ser Leu Tyr Phe Ala Leu Ser Ser Leu Thr 
     450                455                460
Ser Val Gly Phe Gly Asn Val Ser Ala Asn Thr Asp Thr Glu Lys Ile 
 465                470                475                480
Phe Ser Ile Cys Thr Met Leu Ile Gly Ala Leu Met His Ala Val Val 
                 485                490                495
Phe Gly Asn Val Thr Ala Ile Ile Gln Arg Met Tyr Ala Arg Arg Phe 
             500                505                510
Leu Tyr His Ser Arg Thr Arg Asp Leu Arg Asp Tyr Ile Arg Ile His 
         515                520                525
Arg Ile Pro Lys Pro Leu Lys Gln Arg Met Leu Glu Tyr Phe Gln Ala 
     530                535                540
Thr Trp Ala Val Asn Asn Gly Ile Asp Thr Thr Glu Leu Leu Gln Ser 
 545                550                555                560
Leu Pro Asp Glu Leu Arg Ala Asp Ile Ala Met His Leu His Lys Glu 
                 565                570                575
Val Leu Gln Leu Pro Leu Phe Glu Ala Ala Ser Arg Gly Cys Leu Arg 
             580                585                590
Ala Leu Ser Leu Ala Leu Arg Pro Ala Phe Cys Thr Pro Gly Glu Tyr 
         595                600                605
Leu Ile His Gln Gly Asp Ala Leu Gln Ala Leu Tyr Phe Val Cys Ser 
     610                615                620
Gly Ser Met Glu Val Leu Lys Gly Gly Thr Val Leu Ala Ile Leu Gly 
 625                630                635                640
Lys Gly Asp Leu Ile Gly Cys Glu Leu Pro Arg Arg Glu Gln Val Val 
                 645                650                655
Lys Ala Asn Ala Asp Val Lys Gly Leu Thr Tyr Cys Val Leu Gln Cys 
             660                665                670
Leu Gln Leu Ala Gly Leu His Asp Ser Leu Ala Leu Tyr Pro Glu Phe 
         675                680                685
Ala Pro Arg Phe Ser Arg Gly Leu Arg Gly Glu Leu Ser Tyr Asn Leu 
     690                695                700
Gly Ala Gly Gly Gly Ser Ala Glu Val Asp Thr Ser Ser Leu Ser Gly 
 705                710                715                720
Asp Asn Thr Leu Met Ser Thr Leu Glu Glu Lys Glu Thr Asp Gly Glu 
                 725                730                735
Gln Gly Pro Thr Val Ser Pro Ala Pro Ala Asp Glu Pro Ser Ser Pro 
             740                745                750
Leu Leu Ser Pro Gly Cys Thr Ser Ser Ser Ser Ala Ala Lys Leu Leu 
         755                760                765
Ser Pro Arg Arg Thr Ala Pro Arg Pro Arg Leu Gly Gly Arg Gly Arg 
     770                775                780
Pro Gly Arg Ala Gly Ala Leu Lys Ala Glu Ala Gly Pro Ser Ala Pro 
 785                790                795                800
Pro Arg Ala Leu Glu Gly Leu Arg Leu Pro Pro Met Pro Trp Asn Val 
                 805                810                815
Pro Pro Asp Leu Ser Pro Arg Val Val Asp Gly Ile Glu Asp Gly Cys 
             820                825                830
Gly Ser Asp Gln Pro Lys Phe Ser Phe Arg Val Gly Gln Ser Gly Pro 
         835                840                845
Glu Cys Ser Ser Ser Pro Ser Pro Gly Pro Glu Ser Gly Leu Leu Thr 
     850                855                860
Val Pro His Gly Pro Ser Glu Ala Arg Asn Thr Asp Thr Leu Asp Lys 
 865                870                875                880
Leu Arg Gln Ala Val Thr Glu Leu Ser Glu Gln Val Leu Gln Met Arg 
                 885                890                895
Glu Gly Leu Gln Ser Leu Arg Gln Ala Val Gln Leu Val Leu Ala Pro 
             900                905                910
His Arg Glu Gly Pro Cys Pro Arg Ala Ser Gly Glu Gly Pro Cys Pro 
         915                920                925
Ala Ser Thr Ser Gly Leu Leu Gln Pro Leu Cys Val Asp Thr Gly Ala 
     930                935                940
Ser Ser Tyr Cys Leu Gln Pro Pro Ala Gly Ser Val Leu Ser Gly Thr 
 945                950                955                960
Trp Pro His Pro Arg Pro Gly Pro Pro Pro Leu Met Ala Pro Trp Pro 
                 965                970                975
Trp Gly Pro Pro Ala Ser Gln Ser Ser Pro Trp Pro Arg Ala Thr Ala 
             980                985                990
Phe Trp Thr Ser Thr Ser Asp Ser Glu Pro Pro Ala Ser Gly Asp Leu 
         995                1000                1005
Cys Ser Glu Pro Ser Thr Pro Ala Ser Pro Pro Pro Ser Glu Glu Gly 
     1010                1015                1020
Ala Arg Thr Gly Pro Ala Glu Pro Val Ser Gln Ala Glu Ala Thr Ser 
 1025                1030                1035                1040
Thr Gly Glu Pro Pro Pro Gly Ser Gly Gly Leu Ala Leu Pro Trp Asp 
                 1045                1050                1055
Pro His Ser Leu Glu Met Val Leu Ile Gly Cys His Gly Ser Gly Thr 
             1060                1065                1070
Val Gln Trp Thr Gln Glu Glu Gly Thr Gly Val 
         1075                1080



<210> 1424
<211> 1099
<212> DNA
<213> Rattus norvegicus
<308> AJ007632
<400> 1424

gccccgcag  acacatttc  ggacactat  gccacccgt  tcgacggaa  acatagcaa  60
ttcatcctg  ccaatgccc  agtggcaaa  ggtttcccc  tagtctact  ttcagatgg  120
ttctgtgag  tggctgggt  tgctcgaac  gaagtcatg  agaagagtt  cagctgcaa  180
tttctgctt  gggtggaga  caacgagca  ctgatgctt  agatcgaaa  gtccctgga  240
gagaaggta  agttcaaag  agaaattat  ttctacaag  agaatgggg  tccattttg  300
tgcctgttg  atatcgttc  tataaagaa  gagaaagga  atgtggtcc  tttcctggc  360
tcattcaaa  atataacag  cacgaaagt  aagattact  cagaagata  aaaagaaga  420
agagccaaa  gaagatcaa  agcagggag  cacttcgac  cagcccgca  acggagccg  480
gcagtcctt  atcacatct  aggacacct  caaagaaga  aaaagaaca  attgaacat  540
aataataac  tgtttgtag  taaaccggc  tttccagag  ataaggttt  cgatgcaaa  600
aagtccaag  tcatcctgc  gcacttcag  acttttaaa  ctggctggg  ctggctcat  660
ttgctggca  cgttttatg  tgctgtgac  gtcccttac  acgtgtgct  cattggcaa  720
gaggatctg  ccacaactc  gagcacaac  gtcagtgac  tcgctgtgg  gattctctt  780
attatagat  ttattctaa  tttccgaac  acttatgtc  gcaagtctg  ccaagttat  840
tttgaagcg  gatccattt  cacccacta  gtcaccacc  ggttcatca  tgatctgat  900
gctgccctg  cctttgacc  cctgtatgc  ttcaatgtc  cagtggtgt  cctcgtaca  960
cttctgaag  ctgttcggc  gctccgtct  ttgcgcctc  tgcagaagc  ggaccgtta  1020
tctcagcac  gcacaattg  cctcaccct  ctcatgtcc  tgtttgctc  ccttgcaca  1080
tggatagcc  gcatctggt  1099



<210> 1425
<211> 366
<212> PRT
<213> Rattus norvegicus
<308> CAA07591
<400> 1425

Ala Pro Gln Asn Thr Phe Leu Asp Thr Ile Ala Thr Arg Phe Asp Gly 
  1               5                  10                  15
Thr His Ser Asn Phe Ile Leu Ala Asn Ala Gln Val Ala Lys Gly Phe 
             20                  25                  30
Pro Ile Val Tyr Cys Ser Asp Gly Phe Cys Glu Leu Ala Gly Phe Ala 
         35                  40                  45
Arg Thr Glu Val Met Gln Lys Ser Cys Ser Cys Lys Phe Leu Leu Gly 
     50                  55                  60
Val Glu Thr Asn Glu Gln Leu Met Leu Gln Ile Glu Lys Ser Leu Glu 
 65                  70                  75                  80
Glu Lys Val Glu Phe Lys Gly Glu Ile Met Phe Tyr Lys Lys Asn Gly 
                 85                  90                  95
Ala Pro Phe Trp Cys Leu Leu Asp Ile Val Pro Ile Lys Asn Glu Lys 
             100                105                110
Gly Asp Val Val Leu Phe Leu Ala Ser Phe Lys Asp Ile Thr Asp Thr 
         115                120                125
Lys Val Lys Ile Thr Ser Glu Asp Lys Lys Glu Asp Arg Ala Lys Gly 
     130                135                140
Arg Ser Arg Ala Gly Ser His Phe Asp Ser Ala Arg Arg Arg Ser Arg 
 145                150                155                160
Ala Val Leu Tyr His Ile Ser Gly His Leu Gln Arg Arg Glu Lys Asn 
                 165                170                175
Lys Leu Asn Ile Asn Asn Asn Val Phe Val Asp Lys Pro Ala Phe Pro 
             180                185                190
Glu Tyr Lys Val Ser Asp Ala Lys Lys Ser Lys Phe Ile Leu Leu His 
         195                200                205
Phe Ser Thr Phe Lys Ala Gly Trp Asp Trp Leu Ile Leu Leu Ala Thr 
     210                215                220
Phe Tyr Val Ala Val Thr Val Pro Tyr Asn Val Cys Phe Ile Gly Asn 
 225                230                235                240
Glu Asp Leu Ser Thr Thr Arg Ser Thr Thr Val Ser Asp Ile Ala Val 
                 245                250                255
Glu Ile Leu Phe Ile Ile Asp Ile Ile Leu Asn Phe Arg Thr Thr Tyr 
             260                265                270
Val Ser Lys Ser Gly Gln Val Ile Phe Glu Ala Arg Ser Ile Cys Thr 
         275                280                285
His Tyr Val Thr Thr Trp Phe Ile Ile Asp Leu Ile Ala Ala Leu Pro 
     290                295                300
Phe Asp Leu Leu Tyr Ala Phe Asn Val Thr Val Val Ser Leu Val His 
 305                310                315                320
Leu Leu Lys Thr Val Arg Leu Leu Arg Leu Leu Arg Leu Leu Gln Lys 
                 325                330                335
Leu Asp Arg Tyr Ser Gln His Ser Thr Ile Val Leu Thr Leu Leu Met 
             340                345                350
Ser Met Phe Ala Leu Leu Ala His Trp Ile Ala Cys Ile Trp 
         355                360                365



<210> 1426
<211> 1099
<212> DNA
<213> Rattus norvegicus
<308> AJ007632
<400> 1426

gccccgcag  acacatttc  ggacactat  gccacccgt  tcgacggaa  acatagcaa  60
ttcatcctg  ccaatgccc  agtggcaaa  ggtttcccc  tagtctact  ttcagatgg  120
ttctgtgag  tggctgggt  tgctcgaac  gaagtcatg  agaagagtt  cagctgcaa  180
tttctgctt  gggtggaga  caacgagca  ctgatgctt  agatcgaaa  gtccctgga  240
gagaaggta  agttcaaag  agaaattat  ttctacaag  agaatgggg  tccattttg  300
tgcctgttg  atatcgttc  tataaagaa  gagaaagga  atgtggtcc  tttcctggc  360
tcattcaaa  atataacag  cacgaaagt  aagattact  cagaagata  aaaagaaga  420
agagccaaa  gaagatcaa  agcagggag  cacttcgac  cagcccgca  acggagccg  480
gcagtcctt  atcacatct  aggacacct  caaagaaga  aaaagaaca  attgaacat  540
aataataac  tgtttgtag  taaaccggc  tttccagag  ataaggttt  cgatgcaaa  600
aagtccaag  tcatcctgc  gcacttcag  acttttaaa  ctggctggg  ctggctcat  660
ttgctggca  cgttttatg  tgctgtgac  gtcccttac  acgtgtgct  cattggcaa  720
gaggatctg  ccacaactc  gagcacaac  gtcagtgac  tcgctgtgg  gattctctt  780
attatagat  ttattctaa  tttccgaac  acttatgtc  gcaagtctg  ccaagttat  840
tttgaagcg  gatccattt  cacccacta  gtcaccacc  ggttcatca  tgatctgat  900
gctgccctg  cctttgacc  cctgtatgc  ttcaatgtc  cagtggtgt  cctcgtaca  960
cttctgaag  ctgttcggc  gctccgtct  ttgcgcctc  tgcagaagc  ggaccgtta  1020
tctcagcac  gcacaattg  cctcaccct  ctcatgtcc  tgtttgctc  ccttgcaca  1080
tggatagcc  gcatctggt  1099



<210> 1427
<211> 366
<212> PRT
<213> Rattus norvegicus
<308> CAA07591
<400> 1427

Ala Pro Gln Asn Thr Phe Leu Asp Thr Ile Ala Thr Arg Phe Asp Gly 
  1               5                  10                  15
Thr His Ser Asn Phe Ile Leu Ala Asn Ala Gln Val Ala Lys Gly Phe 
             20                  25                  30
Pro Ile Val Tyr Cys Ser Asp Gly Phe Cys Glu Leu Ala Gly Phe Ala 
         35                  40                  45
Arg Thr Glu Val Met Gln Lys Ser Cys Ser Cys Lys Phe Leu Leu Gly 
     50                  55                  60
Val Glu Thr Asn Glu Gln Leu Met Leu Gln Ile Glu Lys Ser Leu Glu 
 65                  70                  75                  80
Glu Lys Val Glu Phe Lys Gly Glu Ile Met Phe Tyr Lys Lys Asn Gly 
                 85                  90                  95
Ala Pro Phe Trp Cys Leu Leu Asp Ile Val Pro Ile Lys Asn Glu Lys 
             100                105                110
Gly Asp Val Val Leu Phe Leu Ala Ser Phe Lys Asp Ile Thr Asp Thr 
         115                120                125
Lys Val Lys Ile Thr Ser Glu Asp Lys Lys Glu Asp Arg Ala Lys Gly 
     130                135                140
Arg Ser Arg Ala Gly Ser His Phe Asp Ser Ala Arg Arg Arg Ser Arg 
 145                150                155                160
Ala Val Leu Tyr His Ile Ser Gly His Leu Gln Arg Arg Glu Lys Asn 
                 165                170                175
Lys Leu Asn Ile Asn Asn Asn Val Phe Val Asp Lys Pro Ala Phe Pro 
             180                185                190
Glu Tyr Lys Val Ser Asp Ala Lys Lys Ser Lys Phe Ile Leu Leu His 
         195                200                205
Phe Ser Thr Phe Lys Ala Gly Trp Asp Trp Leu Ile Leu Leu Ala Thr 
     210                215                220
Phe Tyr Val Ala Val Thr Val Pro Tyr Asn Val Cys Phe Ile Gly Asn 
 225                230                235                240
Glu Asp Leu Ser Thr Thr Arg Ser Thr Thr Val Ser Asp Ile Ala Val 
                 245                250                255
Glu Ile Leu Phe Ile Ile Asp Ile Ile Leu Asn Phe Arg Thr Thr Tyr 
             260                265                270
Val Ser Lys Ser Gly Gln Val Ile Phe Glu Ala Arg Ser Ile Cys Thr 
         275                280                285
His Tyr Val Thr Thr Trp Phe Ile Ile Asp Leu Ile Ala Ala Leu Pro 
     290                295                300
Phe Asp Leu Leu Tyr Ala Phe Asn Val Thr Val Val Ser Leu Val His 
 305                310                315                320
Leu Leu Lys Thr Val Arg Leu Leu Arg Leu Leu Arg Leu Leu Gln Lys 
                 325                330                335
Leu Asp Arg Tyr Ser Gln His Ser Thr Ile Val Leu Thr Leu Leu Met 
             340                345                350
Ser Met Phe Ala Leu Leu Ala His Trp Ile Ala Cys Ile Trp 
         355                360                365



<210> 1428
<211> 1458
<212> DNA
<213> Rattus norvegicus
<308> AJ009698
<400> 1428

ttaccagca  gtgtgcata  ggacaaacg  agaccgatc  cagcaggct  agggtgcaa  60
aacgacctc  tggaccgac  cgcccgcgc  atgcgctcg  acactggct  gagggcgct  120
gtggcgcct  gttgctcgc  cctccttct  tatcttctg  cggcgacgc  cccggatcg  180
gctgtgggc  atcccgcag  ctcagcgtt  acaagtcta  ctgttcgag  ggaaatgat  240
gctaagtac  caaatctgt  cttggagac  tataatatc  cactgacag  acagaccag  300
gtatcagaa  aaaacataa  tttggaaag  ccttctcac  tggaactcg  atgcacgtt  360
acggcaact  aggatgtga  gtcaatgaa  gtgacttgg  agaaagatg  cgcgctcct  420
gagactact  atggtttca  tacaactaa  atgggggac  ccttataca  tcaatacag  480
ttcaccgtt  ttaatagca  acaaatggg  aaatactct  gtttccttg  agaagagct  540
agaggaacc  ttaatatca  agtacccaa  gttcatggg  aaaacaagc  tttgatcac  600
tacgtgggg  attctactg  gctgaagtg  gaatgtcaa  attgtcttc  tttaaattg  660
acttggtac  tgagtaatg  aactgcaca  gttcccatc  atgttcacg  gaatgataa  720
tttgatata  atggttcct  tgctaacga  acaaagctc  aggtaaagc  ccttttgga  780
gaagatgga  gatcctact  gtgccgggc  gccttcccg  taggggaga  tgaggaaca  840
attaagctg  ttgtgctga  tttcatggt  cctctcaag  cattccttg  cataattgc  900
gaagtcatc  tcttagtgg  catcatcct  ctttgtgaa  tgtacacgc  gaagaaaaa  960
aatgaccca  atgatggga  agaatttga  caaatcgaa  agttgaaat  agatgatag  1020
aatggaata  aaaacaatg  cccccggta  agaaaaacg  actctgggg  tcagtgaat  1080
caaaaagaa  tttttgcct  gggaagacg  acagcactg  agtttgaat  tcagcattc  1140
ttggagaac  tccgagttt  agatttttc  gaagacaaa  atgccctca  tgtgcccag  1200
agtagtttc  taaacaata  agaccatct  ctacctaaa  atgtatttt  attgtgtaa  1260
tgcttttca  taaagcaag  tacattgtt  cagctgtgt  ctgtgagct  taacctaga  1320
aataaagtt  accctctct  ggagatcag  gggacaggg  agacaccag  aaaatcagt  1380
aataaccca  aaagtaaat  ttgctaaag  tctgtttat  accaaagaa  ttattaaag  1440
gaaagtgtt  gccaaaaa  1458



<210> 1429
<211> 328
<212> PRT
<213> Rattus norvegicus
<308> CAA08796
<400> 1429

Met Arg Ser His Thr Gly Leu Arg Ala Leu Val Ala Pro Gly Cys Ser 
  1               5                  10                  15
Leu Leu Leu Leu Tyr Leu Leu Ala Ala Thr Arg Pro Asp Arg Ala Val 
             20                  25                  30
Gly Asp Pro Ala Asp Ser Ala Phe Thr Ser Leu Pro Val Arg Glu Glu 
         35                  40                  45
Met Met Ala Lys Tyr Ala Asn Leu Ser Leu Glu Thr Tyr Asn Ile Ser 
     50                  55                  60
Leu Thr Glu Gln Thr Arg Val Ser Glu Gln Asn Ile Thr Leu Glu Arg 
 65                  70                  75                  80
Pro Ser His Leu Glu Leu Glu Cys Thr Phe Thr Ala Thr Glu Asp Val 
                 85                  90                  95
Met Ser Met Asn Val Thr Trp Lys Lys Asp Asp Ala Leu Leu Glu Thr 
             100                105                110
Thr Asp Gly Phe Asn Thr Thr Lys Met Gly Asp Thr Leu Tyr Ser Gln 
         115                120                125
Tyr Arg Phe Thr Val Phe Asn Ser Lys Gln Met Gly Lys Tyr Ser Cys 
     130                135                140
Phe Leu Gly Glu Glu Leu Arg Gly Thr Phe Asn Ile Arg Val Pro Lys 
 145                150                155                160
Val His Gly Lys Asn Lys Pro Leu Ile Thr Tyr Val Gly Asp Ser Thr 
                 165                170                175
Val Leu Lys Cys Glu Cys Gln Asn Cys Leu Pro Leu Asn Trp Thr Trp 
             180                185                190
Tyr Met Ser Asn Gly Thr Ala Gln Val Pro Ile Asp Val His Val Asn 
         195                200                205
Asp Lys Phe Asp Ile Asn Gly Ser Tyr Ala Asn Glu Thr Lys Leu Lys 
     210                215                220
Val Lys His Leu Leu Glu Glu Asp Gly Gly Ser Tyr Trp Cys Arg Ala 
 225                230                235                240
Ala Phe Pro Leu Gly Glu Ser Glu Glu His Ile Lys Leu Val Val Leu 
                 245                250                255
Ser Phe Met Val Pro Leu Lys Pro Phe Leu Ala Ile Ile Ala Glu Val 
             260                265                270
Ile Leu Leu Val Ala Ile Ile Leu Leu Cys Glu Val Tyr Thr Gln Lys 
         275                280                285
Lys Lys Asn Asp Pro Asp Asp Gly Lys Glu Phe Glu Gln Ile Glu Gln 
     290                295                300
Leu Lys Ser Asp Asp Ser Asn Gly Ile Glu Asn Asn Val Pro Arg Tyr 
 305                310                315                320
Arg Lys Thr Asp Ser Gly Asp Gln 
                 325



<210> 1430
<211> 2139
<212> DNA
<213> Homo sapiens
<308> BC014858
<400> 1430

cccagttac  agcaagtgt  cacagggac  aacggagac  gatcgcagc  agctgaggg  60
gccttagcg  cctcctgga  agacccgcc  gcgccatgc  ctcgcacac  ggcctgagg  120
cgcttgtgg  gcctggtta  ccgctcctc  ttctatgtc  tctggcggc  acgcgccct  180
atccggctg  gggcgatcc  acagatcca  cttttacaa  tctacctgt  cgagaagaa  240
tgatggcga  atactcaaa  ctttcctta  agagctgta  tatctcagt  acggaaaag  300
ccaatgtat  agtagaaga  aacgtaatt  tggaaaagc  ttctcatgt  gaactcaaa  360
gcgtgtaca  agcaactaa  gatttgaac  tgatgaatg  gacttggaa  aaagatgat  420
agccccttg  gactacggg  gacttcaat  caactaaaa  gggcaacac  ttaaccagt  480
agtacaggt  catcgtttt  aatagcaaa  aattgggaa  atattcttg  gtctttgga  540
aaaaggaac  aagagggac  tttaacatc  acgtaccca  agctcatgg  aaaaaaaag  600
cgttgatcg  ttacgtggg  gattctact  tgctgaagt  tgtatgtca  gattgtctt  660
ctttaaatt  gacttggta  atgggtaat  aaaccgcac  ggttcccat  gacgctcac  720
cgaatgaaa  gtatatcat  aatggttcc  atgccaatg  aacaaggct  aagattaag  780
atcttttgg  ggaagatgg  ggatcctac  ggtgtcgtg  caccttcca  ttaggggag  840
gtgaggagc  gaatgagct  gttgtgctg  gcttcctgg  gcccctcaa  ccatttctg  900
ccatacttg  cgaagtcat  ctcttggtg  ccatcattc  gctttgtga  gtgtacaca  960
acaagaaaa  gaatgaccc  gatgctggg  aagaatttg  acaaattga  cagctgaaa  1020
cagatgata  caatggcat  gaaaacaat  tcccccggt  cagaaaaac  gactctgca  1080
atcagtgaa  acagaaaga  catctcgcc  tgggaagaa  tacagcgtt  gagtttgta  1140
ttcagcttc  ttattttag  tttttaaaa  acaaagatg  cctcaacgt  cacagaagt  1200
gctttatga  caatatagt  catctccta  ctaaagatg  actttcatt  tgtaattgc  1260
ttccattaa  gcaaggtca  ttgtttcag  tgtgttctg  gagctgtaa  ctagataat  1320
aactcccct  tgtgggtac  gggtggaca  cagcaaaat  acttaataa  ccacaaata  1380
atatcgccg  agatctgtt  attaccaaa  aatttatta  agagaaagc  tttgccagt  1440
gtcttaagt  tttgcctcc  ccagacatc  tacctatag  agtatttat  acagttttc  1500
tgtgaagtg  atccagtgt  gagtgtgat  tctctagga  atggaaagt  tgctttcaa  1560
atcggtggc  acactgcag  ctagacact  agataaact  gtgctctat  aataatggt  1620
caaagtaag  gagttcaaa  gcttgtgcc  tggccacta  attaccaga  cttctcatc  1680
tcattgcac  catttctgc  ctttctatc  caagccgaa  agcttccca  ccttaagta  1740
aacattttc  ttgttcttt  tcattgggg  ttggacttc  atagtcttc  gaggccaga  1800
ccacgttgt  acagtacaa  cccgctcgc  acctgcatg  ctttgtggc  catggtttc  1860
gggtgcctt  atgtgccat  tctttcctg  taccatacc  ggctaaaat  cattcttag  1920
gttttccaa  aataattcc  ttgtctagt  tacaggagg  ctagtgcac  atctttatg  1980
tgctgcgaa  gccttagac  taacttcaa  attgtatct  agatacttt  tgaacttag  2040
accaaatca  gtcagaatt  taatggaca  ggaaacttg  caatggttt  aaatgaaat  2100
aaatgtgcc  tggatggtt  gattaaaaa  aaaaaaaaa  2139



<210> 1431
<211> 330
<212> PRT
<213> Homo sapiens
<308> P21995
<400> 1431

Met Arg Ser His Thr Gly Leu Arg Ala Leu Val Ala Pro Gly Tyr Pro 
  1               5                  10                  15
Leu Leu Leu Leu Cys Leu Leu Ala Ala Thr Arg Pro Asp Pro Ala Glu 
             20                  25                  30
Gly Asp Pro Thr Asp Pro Thr Phe Thr Ser Leu Pro Val Arg Glu Glu 
         35                  40                  45
Met Met Ala Lys Tyr Ser Asn Leu Ser Leu Lys Ser Cys Asn Ile Ser 
     50                  55                  60
Val Thr Glu Lys Ser Asn Val Ser Val Glu Glu Asn Val Ile Leu Glu 
 65                  70                  75                  80
Lys Pro Ser His Val Glu Leu Lys Cys Val Tyr Thr Ala Thr Lys Asp 
                 85                  90                  95
Leu Asn Leu Met Asn Val Thr Trp Lys Lys Asp Asp Glu Pro Leu Glu 
             100                105                110
Thr Thr Gly Asp Phe Asn Thr Thr Lys Met Gly Asn Thr Leu Thr Ser 
         115                120                125
Gln Tyr Arg Phe Ile Val Phe Asn Ser Lys Gln Leu Gly Lys Tyr Ser 
     130                135                140
Cys Val Phe Gly Glu Lys Glu Leu Arg Gly Thr Phe Asn Ile His Val 
 145                150                155                160
Pro Gln Ser Ser Trp Glu Lys Lys Ser Leu Ile Ala Tyr Val Gly Asp 
                 165                170                175
Ser Thr Val Leu Lys Cys Val Cys Gln Asp Cys Leu Pro Leu Asn Trp 
             180                185                190
Thr Trp Tyr Met Gly Asn Glu Thr Ala Gln Val Pro Ile Asp Ala His 
         195                200                205
Ser Asn Glu Lys Tyr Ile Ile Asn Gly Ser His Ala Asn Glu Thr Arg 
     210                215                220
Leu Lys Ile Lys His Leu Leu Glu Glu Asp Gly Gly Ser Tyr Trp Cys 
 225                230                235                240
Arg Ala Thr Phe Gln Leu Gly Glu Ser Glu Glu Gln Asn Glu Leu Val 
                 245                250                255
Val Leu Ser Phe Leu Val Pro Leu Lys Pro Phe Leu Ala Ile Leu Ala 
             260                265                270
Glu Val Ile Leu Leu Val Ala Ile Ile Leu Leu Cys Glu Val Tyr Thr 
         275                280                285
His Lys Lys Lys Asn Gly Pro Asp Ala Gly Lys Glu Phe Glu Gln Ile 
     290                295                300
Glu Gln Leu Lys Ser Asp Asp Ser Asn Gly Ile Glu Asn Asn Val Pro 
 305                310                315                320
Arg Tyr Arg Lys Thr Asp Ser Ala Asp Gln 
                 325                330



<210> 1432
<211> 1458
<212> DNA
<213> Rattus norvegicus
<308> AJ009698
<400> 1432

ttaccagca  gtgtgcata  ggacaaacg  agaccgatc  cagcaggct  agggtgcaa  60
aacgacctc  tggaccgac  cgcccgcgc  atgcgctcg  acactggct  gagggcgct  120
gtggcgcct  gttgctcgc  cctccttct  tatcttctg  cggcgacgc  cccggatcg  180
gctgtgggc  atcccgcag  ctcagcgtt  acaagtcta  ctgttcgag  ggaaatgat  240
gctaagtac  caaatctgt  cttggagac  tataatatc  cactgacag  acagaccag  300
gtatcagaa  aaaacataa  tttggaaag  ccttctcac  tggaactcg  atgcacgtt  360
acggcaact  aggatgtga  gtcaatgaa  gtgacttgg  agaaagatg  cgcgctcct  420
gagactact  atggtttca  tacaactaa  atgggggac  ccttataca  tcaatacag  480
ttcaccgtt  ttaatagca  acaaatggg  aaatactct  gtttccttg  agaagagct  540
agaggaacc  ttaatatca  agtacccaa  gttcatggg  aaaacaagc  tttgatcac  600
tacgtgggg  attctactg  gctgaagtg  gaatgtcaa  attgtcttc  tttaaattg  660
acttggtac  tgagtaatg  aactgcaca  gttcccatc  atgttcacg  gaatgataa  720
tttgatata  atggttcct  tgctaacga  acaaagctc  aggtaaagc  ccttttgga  780
gaagatgga  gatcctact  gtgccgggc  gccttcccg  taggggaga  tgaggaaca  840
attaagctg  ttgtgctga  tttcatggt  cctctcaag  cattccttg  cataattgc  900
gaagtcatc  tcttagtgg  catcatcct  ctttgtgaa  tgtacacgc  gaagaaaaa  960
aatgaccca  atgatggga  agaatttga  caaatcgaa  agttgaaat  agatgatag  1020
aatggaata  aaaacaatg  cccccggta  agaaaaacg  actctgggg  tcagtgaat  1080
caaaaagaa  tttttgcct  gggaagacg  acagcactg  agtttgaat  tcagcattc  1140
ttggagaac  tccgagttt  agatttttc  gaagacaaa  atgccctca  tgtgcccag  1200
agtagtttc  taaacaata  agaccatct  ctacctaaa  atgtatttt  attgtgtaa  1260
tgcttttca  taaagcaag  tacattgtt  cagctgtgt  ctgtgagct  taacctaga  1320
aataaagtt  accctctct  ggagatcag  gggacaggg  agacaccag  aaaatcagt  1380
aataaccca  aaagtaaat  ttgctaaag  tctgtttat  accaaagaa  ttattaaag  1440
gaaagtgtt  gccaaaaa  1458



<210> 1433
<211> 328
<212> PRT
<213> Rattus norvegicus
<308> CAA08796
<400> 1433

Met Arg Ser His Thr Gly Leu Arg Ala Leu Val Ala Pro Gly Cys Ser 
  1               5                  10                  15
Leu Leu Leu Leu Tyr Leu Leu Ala Ala Thr Arg Pro Asp Arg Ala Val 
             20                  25                  30
Gly Asp Pro Ala Asp Ser Ala Phe Thr Ser Leu Pro Val Arg Glu Glu 
         35                  40                  45
Met Met Ala Lys Tyr Ala Asn Leu Ser Leu Glu Thr Tyr Asn Ile Ser 
     50                  55                  60
Leu Thr Glu Gln Thr Arg Val Ser Glu Gln Asn Ile Thr Leu Glu Arg 
 65                  70                  75                  80
Pro Ser His Leu Glu Leu Glu Cys Thr Phe Thr Ala Thr Glu Asp Val 
                 85                  90                  95
Met Ser Met Asn Val Thr Trp Lys Lys Asp Asp Ala Leu Leu Glu Thr 
             100                105                110
Thr Asp Gly Phe Asn Thr Thr Lys Met Gly Asp Thr Leu Tyr Ser Gln 
         115                120                125
Tyr Arg Phe Thr Val Phe Asn Ser Lys Gln Met Gly Lys Tyr Ser Cys 
     130                135                140
Phe Leu Gly Glu Glu Leu Arg Gly Thr Phe Asn Ile Arg Val Pro Lys 
 145                150                155                160
Val His Gly Lys Asn Lys Pro Leu Ile Thr Tyr Val Gly Asp Ser Thr 
                 165                170                175
Val Leu Lys Cys Glu Cys Gln Asn Cys Leu Pro Leu Asn Trp Thr Trp 
             180                185                190
Tyr Met Ser Asn Gly Thr Ala Gln Val Pro Ile Asp Val His Val Asn 
         195                200                205
Asp Lys Phe Asp Ile Asn Gly Ser Tyr Ala Asn Glu Thr Lys Leu Lys 
     210                215                220
Val Lys His Leu Leu Glu Glu Asp Gly Gly Ser Tyr Trp Cys Arg Ala 
 225                230                235                240
Ala Phe Pro Leu Gly Glu Ser Glu Glu His Ile Lys Leu Val Val Leu 
                 245                250                255
Ser Phe Met Val Pro Leu Lys Pro Phe Leu Ala Ile Ile Ala Glu Val 
             260                265                270
Ile Leu Leu Val Ala Ile Ile Leu Leu Cys Glu Val Tyr Thr Gln Lys 
         275                280                285
Lys Lys Asn Asp Pro Asp Asp Gly Lys Glu Phe Glu Gln Ile Glu Gln 
     290                295                300
Leu Lys Ser Asp Asp Ser Asn Gly Ile Glu Asn Asn Val Pro Arg Tyr 
 305                310                315                320
Arg Lys Thr Asp Ser Gly Asp Gln 
                 325



<210> 1434
<211> 2139
<212> DNA
<213> Homo sapiens
<308> BC014858
<400> 1434

cccagttac  agcaagtgt  cacagggac  aacggagac  gatcgcagc  agctgaggg  60
gccttagcg  cctcctgga  agacccgcc  gcgccatgc  ctcgcacac  ggcctgagg  120
cgcttgtgg  gcctggtta  ccgctcctc  ttctatgtc  tctggcggc  acgcgccct  180
atccggctg  gggcgatcc  acagatcca  cttttacaa  tctacctgt  cgagaagaa  240
tgatggcga  atactcaaa  ctttcctta  agagctgta  tatctcagt  acggaaaag  300
ccaatgtat  agtagaaga  aacgtaatt  tggaaaagc  ttctcatgt  gaactcaaa  360
gcgtgtaca  agcaactaa  gatttgaac  tgatgaatg  gacttggaa  aaagatgat  420
agccccttg  gactacggg  gacttcaat  caactaaaa  gggcaacac  ttaaccagt  480
agtacaggt  catcgtttt  aatagcaaa  aattgggaa  atattcttg  gtctttgga  540
aaaaggaac  aagagggac  tttaacatc  acgtaccca  agctcatgg  aaaaaaaag  600
cgttgatcg  ttacgtggg  gattctact  tgctgaagt  tgtatgtca  gattgtctt  660
ctttaaatt  gacttggta  atgggtaat  aaaccgcac  ggttcccat  gacgctcac  720
cgaatgaaa  gtatatcat  aatggttcc  atgccaatg  aacaaggct  aagattaag  780
atcttttgg  ggaagatgg  ggatcctac  ggtgtcgtg  caccttcca  ttaggggag  840
gtgaggagc  gaatgagct  gttgtgctg  gcttcctgg  gcccctcaa  ccatttctg  900
ccatacttg  cgaagtcat  ctcttggtg  ccatcattc  gctttgtga  gtgtacaca  960
acaagaaaa  gaatgaccc  gatgctggg  aagaatttg  acaaattga  cagctgaaa  1020
cagatgata  caatggcat  gaaaacaat  tcccccggt  cagaaaaac  gactctgca  1080
atcagtgaa  acagaaaga  catctcgcc  tgggaagaa  tacagcgtt  gagtttgta  1140
ttcagcttc  ttattttag  tttttaaaa  acaaagatg  cctcaacgt  cacagaagt  1200
gctttatga  caatatagt  catctccta  ctaaagatg  actttcatt  tgtaattgc  1260
ttccattaa  gcaaggtca  ttgtttcag  tgtgttctg  gagctgtaa  ctagataat  1320
aactcccct  tgtgggtac  gggtggaca  cagcaaaat  acttaataa  ccacaaata  1380
atatcgccg  agatctgtt  attaccaaa  aatttatta  agagaaagc  tttgccagt  1440
gtcttaagt  tttgcctcc  ccagacatc  tacctatag  agtatttat  acagttttc  1500
tgtgaagtg  atccagtgt  gagtgtgat  tctctagga  atggaaagt  tgctttcaa  1560
atcggtggc  acactgcag  ctagacact  agataaact  gtgctctat  aataatggt  1620
caaagtaag  gagttcaaa  gcttgtgcc  tggccacta  attaccaga  cttctcatc  1680
tcattgcac  catttctgc  ctttctatc  caagccgaa  agcttccca  ccttaagta  1740
aacattttc  ttgttcttt  tcattgggg  ttggacttc  atagtcttc  gaggccaga  1800
ccacgttgt  acagtacaa  cccgctcgc  acctgcatg  ctttgtggc  catggtttc  1860
gggtgcctt  atgtgccat  tctttcctg  taccatacc  ggctaaaat  cattcttag  1920
gttttccaa  aataattcc  ttgtctagt  tacaggagg  ctagtgcac  atctttatg  1980
tgctgcgaa  gccttagac  taacttcaa  attgtatct  agatacttt  tgaacttag  2040
accaaatca  gtcagaatt  taatggaca  ggaaacttg  caatggttt  aaatgaaat  2100
aaatgtgcc  tggatggtt  gattaaaaa  aaaaaaaaa  2139



<210> 1435
<211> 330
<212> PRT
<213> Homo sapiens
<308> P21995
<400> 1435

Met Arg Ser His Thr Gly Leu Arg Ala Leu Val Ala Pro Gly Tyr Pro 
  1               5                  10                  15
Leu Leu Leu Leu Cys Leu Leu Ala Ala Thr Arg Pro Asp Pro Ala Glu 
             20                  25                  30
Gly Asp Pro Thr Asp Pro Thr Phe Thr Ser Leu Pro Val Arg Glu Glu 
         35                  40                  45
Met Met Ala Lys Tyr Ser Asn Leu Ser Leu Lys Ser Cys Asn Ile Ser 
     50                  55                  60
Val Thr Glu Lys Ser Asn Val Ser Val Glu Glu Asn Val Ile Leu Glu 
 65                  70                  75                  80
Lys Pro Ser His Val Glu Leu Lys Cys Val Tyr Thr Ala Thr Lys Asp 
                 85                  90                  95
Leu Asn Leu Met Asn Val Thr Trp Lys Lys Asp Asp Glu Pro Leu Glu 
             100                105                110
Thr Thr Gly Asp Phe Asn Thr Thr Lys Met Gly Asn Thr Leu Thr Ser 
         115                120                125
Gln Tyr Arg Phe Ile Val Phe Asn Ser Lys Gln Leu Gly Lys Tyr Ser 
     130                135                140
Cys Val Phe Gly Glu Lys Glu Leu Arg Gly Thr Phe Asn Ile His Val 
 145                150                155                160
Pro Gln Ser Ser Trp Glu Lys Lys Ser Leu Ile Ala Tyr Val Gly Asp 
                 165                170                175
Ser Thr Val Leu Lys Cys Val Cys Gln Asp Cys Leu Pro Leu Asn Trp 
             180                185                190
Thr Trp Tyr Met Gly Asn Glu Thr Ala Gln Val Pro Ile Asp Ala His 
         195                200                205
Ser Asn Glu Lys Tyr Ile Ile Asn Gly Ser His Ala Asn Glu Thr Arg 
     210                215                220
Leu Lys Ile Lys His Leu Leu Glu Glu Asp Gly Gly Ser Tyr Trp Cys 
 225                230                235                240
Arg Ala Thr Phe Gln Leu Gly Glu Ser Glu Glu Gln Asn Glu Leu Val 
                 245                250                255
Val Leu Ser Phe Leu Val Pro Leu Lys Pro Phe Leu Ala Ile Leu Ala 
             260                265                270
Glu Val Ile Leu Leu Val Ala Ile Ile Leu Leu Cys Glu Val Tyr Thr 
         275                280                285
His Lys Lys Lys Asn Gly Pro Asp Ala Gly Lys Glu Phe Glu Gln Ile 
     290                295                300
Glu Gln Leu Lys Ser Asp Asp Ser Asn Gly Ile Glu Asn Asn Val Pro 
 305                310                315                320
Arg Tyr Arg Lys Thr Asp Ser Ala Asp Gln 
                 325                330



<210> 1436
<211> 1563
<212> DNA
<213> Rattus norvegicus
<308> AJ011607
<400> 1436

gtcaagatg  agttctcag  aaggacccg  aagaagctg  gattggcag  tgaccagag  60
aacgcttgt  accctcaca  ccttcagtt  tatctgcag  cacctactg  aaacatatc  120
ttgacagag  ttgaaagct  ggcttttga  agagtaaaa  tgcttaaag  aattgagaa  180
cttggtgtg  gctatgtga  aggaaccga  cagtaccag  gtaaactgg  ggctgagat  240
cgaaagctc  agttttcgt  cagggagaa  ctggaggat  agtacgagc  tcggaggag  300
gaccacatc  cccacttca  cctgcgcct  gcttactgc  agtcggaag  tcttagacg  360
tggtttatt  aacaggaga  ggatctgct  cggttccga  tcagtattt  acccaagga  420
aaagtccag  gtttcttga  ggatactca  ttgcatttt  aggctatca  tgatgagga  480
aagaccctt  gggaacagg  tatcatggc  tcctctccc  gcctaagtg  ggtcaggtg  540
gaatcggag  cagtgtata  ggtcccctt  gctgacgct  tggacctgt  cagaggaag  600
aaagtctac  tggaagacg  ctttgctta  gtgccactt  aggacattg  ggccattat  660
ctgaacgag  ttagagcca  gctgtctaa  gccttggca  taacagcca  gtccctgcc  720
gctgtgcag  ccgatgaac  acttcagcc  ctgctcagc  acctcagtc  ttcttacac  780
ggccaagat  atagtaccc  gaagagcac  gggaagatt  ccttagatc  gattgattc  840
ctttcaaca  aatccttcc  accttgcat  cgtcagctg  acaaggcgc  gagggaaaa  900
caccatctt  gtcatggag  ccggatgca  tatggcctg  tcctcaagg  cattgggct  960
acgttggag  aagcattgc  gttctggaa  caagagttt  tcaaaggaa  gatggaccc  1020
gacaagttt  ataaaggtt  ctcttacaa  atccgacat  gctttggaa  ggaaggcaa  1080
aggacagac  atacgccat  cagttgcat  aagattatc  tgaccaacc  accaagcca  1140
ggggatttc  atgggtgcc  attccgtca  agtgatgca  agctgctga  gcagaagat  1200
cagacctac  agatccctg  ctcggggat  agccagatt  tggatttgg  aaaggggaa  1260
cattaccag  tggcctgtc  gaagtactt  gagatgacg  acaatgtgg  cgattgtgg  1320
ttttctttg  atcatccaa  tcagttctt  tttgagagc  agcgaatcc  aactggtgg  1380
aaagatatc  agaaggaag  aagccaccc  gaaacgcct  agcacaaac  cagcaccca  1440
aagaccaag  atgccacgt  tgctctggc  tctctagat  cctccctgg  aatggatct  1500
gaggggcta  aagactact  tagtaaatg  cgtggcccc  ggagcaact  gagcaaata  1560
att  1563



<210> 1437
<211> 507
<212> PRT
<213> Rattus norvegicus
<308> CAA09722
<400> 1437

Met Gln Phe Ser Gly Arg Thr Arg Lys Lys Leu Arg Leu Ala Gly Asp 
  1               5                  10                  15
Gln Arg Asn Ala Cys Tyr Pro His Ser Leu Gln Phe Tyr Leu Gln Pro 
             20                  25                  30
Pro Thr Glu Asn Ile Ser Leu Thr Glu Phe Glu Ser Leu Ala Phe Asp 
         35                  40                  45
Arg Val Lys Leu Leu Lys Ala Ile Glu Asn Leu Gly Val Ser Tyr Val 
     50                  55                  60
Lys Gly Thr Glu Gln Tyr Gln Ser Lys Leu Glu Ala Glu Ile Arg Lys 
 65                  70                  75                  80
Leu Lys Phe Ser Tyr Arg Glu Asn Leu Glu Asp Glu Tyr Glu Pro Arg 
                 85                  90                  95
Arg Arg Asp His Ile Ser His Phe Ile Leu Arg Leu Ala Tyr Cys Gln 
             100                105                110
Ser Glu Asp Leu Arg Arg Trp Phe Ile Gln Gln Glu Met Asp Leu Leu 
         115                120                125
Arg Phe Arg Phe Ser Ile Leu Pro Lys Asp Lys Val Gln Ser Phe Leu 
     130                135                140
Lys Asp Thr His Leu His Phe Glu Ala Ile Ser Asp Glu Glu Lys Thr 
 145                150                155                160
Leu Arg Glu Gln Asp Ile Met Ala Ser Ser Pro Ser Leu Ser Gly Val 
                 165                170                175
Arg Trp Glu Ser Glu Ser Val Tyr Lys Val Pro Phe Ala Asp Ala Leu 
             180                185                190
Asp Leu Phe Arg Gly Arg Lys Val Tyr Leu Glu Asp Gly Phe Ala Tyr 
         195                200                205
Val Pro Leu Lys Asp Ile Val Ala Ile Ile Leu Asn Glu Phe Arg Ala 
     210                215                220
Thr Leu Ser Lys Ala Leu Ala Leu Thr Ala Arg Ser Leu Pro Ala Val 
 225                230                235                240
Gln Ser Asp Glu Arg Leu Gln Pro Leu Leu Ser His Leu Ser His Ser 
                 245                250                255
Tyr Thr Gly Gln Asp Tyr Ser Thr Gln Lys Ser Thr Gly Lys Ile Ser 
             260                265                270
Leu Asp Gln Ile Asp Ser Leu Ser Thr Lys Ser Phe Pro Pro Cys Met 
         275                280                285
Arg Gln Leu His Lys Ala Leu Arg Glu Asn His His Leu Arg His Gly 
     290                295                300
Gly Arg Met Gln Tyr Gly Leu Phe Leu Lys Gly Ile Gly Leu Thr Leu 
 305                310                315                320
Glu Gln Ala Leu Gln Phe Trp Lys Gln Glu Phe Ile Lys Gly Lys Met 
                 325                330                335
Asp Pro Asp Lys Phe Asp Lys Gly Tyr Ser Tyr Asn Ile Arg His Ser 
             340                345                350
Phe Gly Lys Glu Gly Lys Arg Thr Asp Tyr Thr Pro Phe Ser Cys Met 
         355                360                365
Lys Ile Ile Leu Thr Asn Pro Pro Ser Gln Gly Asp Phe His Gly Cys 
     370                375                380
Pro Phe Arg His Ser Asp Ala Glu Leu Leu Lys Gln Lys Met Gln Thr 
 385                390                395                400
Tyr Lys Ile Pro Ala Ser Gly Ile Ser Gln Ile Leu Asp Leu Val Lys 
                 405                410                415
Gly Asn His Tyr Gln Val Ala Cys Gln Lys Tyr Phe Glu Met Thr His 
             420                425                430
Asn Val Asp Asp Cys Gly Phe Ser Leu Asn His Pro Asn Gln Phe Phe 
         435                440                445
Phe Glu Ser Gln Arg Ile Leu Thr Gly Gly Lys Asp Ile Lys Lys Glu 
     450                455                460
Ala Ser His Pro Glu Thr Pro Gln His Lys Pro Ser Thr Gln Lys Thr 
 465                470                475                480
Lys Asp Ala Thr Ser Ala Leu Ala Ser Leu Asp Ser Ser Leu Glu Met 
                 485                490                495
Asp Leu Glu Gly Leu Glu Asp Tyr Phe Ser Lys 
             500                505



<210> 1438
<211> 2306
<212> DNA
<213> Homo sapiens
<308> NM_000947
<400> 1438

ggtttcata  gaactctcc  gccacccgg  aacagctgg  tgccaccgt  tgtgttttc  60
gagtttgta  tcttgcagg  gaccaagat  gagttttct  gaagaaagc  gaggaagct  120
aggttggca  gtgaccaga  gaatgcttc  taccctcat  gccttcagt  ttacttgca  180
ccaccttct  aaaacatat  tttaacaga  tttgaaaac  tggctattg  tagagttaa  240
ttgttaaaa  cagttgaaa  tcttggagt  agctatgtg  aaggaactg  acaatacca  300
agtaagttg  agagtgagc  tcggaagct  aagttttcc  acagagaga  gctagaaga  360
gaatatgaa  cacgaagaa  agatcatat  tctcatttt  ttttgcggc  tgcttattg  420
cagtctgaa  aacttagac  ctggttcat  caacaagaa  tggatctcc  tcgatttag  480
tttagtatt  tacccaagg  taaaattca  gatttctta  aggatagcc  attgcagtt  540
gaggctata  gtgatgaag  gaagactct  cgagaacag  agattgttg  ctcatcacc  600
agtttaagt  gacttaagt  ggggttcga  tccatttat  agatccctt  tgctgatgc  660
ctggatttg  ttcgaggaa  gaaagtcta  ttggaagat  gctttgctt  cgtaccact  720
aaggacatt  tggcaatca  cctgaatga  tttagagcc  aactgtcca  ggctttggc  780
ttaacagcc  ggtccttgc  tgctgtgca  tctgatgaa  gacttcagc  tctgctcaa  840
cacctcagt  attcctaca  tggccaaga  tacagtacc  agggaaatg  tgggaagat  900
tctttagat  agattgatt  gctttctac  aaatccttc  caccttgca  gcgtcagtt  960
cataaagcc  tgcgggaaa  tcaccatct  cgtcatgga  gccgaatgc  gtatggcct  1020
tttctgaag  gcattggtt  aactttgga  caggcattg  agttctgga  gcaagaatt  1080
atcaaagga  agatggatc  agacaagtt  gataaaggt  actcttaca  catccgtca  1140
agctttgga  aggaaggca  gaggacaga  tatacacct  tcagttgcc  gaagattat  1200
ctgtccaat  caccaagcc  aggggatta  catgggtgc  cattccgtc  cagtgatcc  1260
gagctgctg  agcaaaagt  gcagtcata  aagatctct  ctggaggga  aagccagat  1320
ttggattta  taaagggga  acattacca  gtagcctgt  aaaaatact  tgagatgat  1380
cacaatgtg  atgattgtg  cttttcttt  aatcatcct  atcagttct  ttgtgagag  1440
caacgtatt  taaatggtg  taaagacat  aagaaggaa  ctatccaac  agaaactcc  1500
caacccaaa  caagtgtcc  gaaaaccaa  gatgcatca  ctgctctgg  ctctttaaa  1560
tcctctctg  aaatggata  ggaaggact  gaagattac  ttagtgaag  ttcttaggc  1620
gttttataa  cctttttcc  caatagcct  tttcctgtt  ttaagattt  gcctttgtt  1680
ttgaaaaag  gtttcactg  caccaaggc  tagtgcagt  acacaatta  agctgattg  1740
agccttgac  ttcccagct  aagtgatcc  cctacctca  cctcccaag  agttaggac  1800
cacaggtgt  cacctcata  ccagataat  tttttcaat  tttttttgt  gaggtgggg  1860
gtctcccta  gttgcccag  cagatctca  actcctggg  tcaagcgat  ctcacacct  1920
agcgtccca  agtgctggg  ttacagttg  gagccactg  gcctggcct  ttttttttt  1980
taacctttt  gtttaactt  tctcttcac  gcatcccaa  ccatctaca  gcatgcaca  2040
ttattagga  aggaggttt  aggtaacaa  agagacttt  actatattt  gctttgaca  2100
aaggaaaga  gaggagttt  tattaaaat  tgtcacttg  gtgatgtca  ttaagtcct  2160
ttttaggag  taaaaacag  tttggggac  ggttaaagt  ccccagaaa  tacaataaa  2220
aacaacttt  gttttaact  ttaatcact  tgtaatttt  actcaatcc  tttctggac  2280
atttttgtt  ataaatatc  aagtgt  2306



<210> 1439
<211> 509
<212> PRT
<213> Homo sapiens
<308> P49643
<400> 1439

Met Glu Phe Ser Gly Arg Lys Arg Arg Lys Leu Arg Leu Ala Gly Asp 
  1               5                  10                  15
Gln Arg Asn Ala Ser Tyr Pro His Cys Leu Gln Phe Tyr Leu Gln Pro 
             20                  25                  30
Pro Ser Glu Asn Ile Ser Leu Thr Glu Phe Glu Asn Leu Ala Ile Asp 
         35                  40                  45
Arg Val Lys Leu Leu Lys Ser Val Glu Asn Leu Gly Val Ser Tyr Val 
     50                  55                  60
Lys Gly Thr Glu Gln Tyr Gln Ser Lys Leu Glu Ser Glu Leu Arg Lys 
 65                  70                  75                  80
Leu Lys Phe Ser Tyr Arg Glu Lys Leu Glu Asp Glu Tyr Glu Pro Arg 
                 85                  90                  95
Arg Arg Asp His Ile Ser His Phe Ile Leu Arg Leu Ala Tyr Cys Gln 
             100                105                110
Ser Glu Glu Leu Arg Arg Trp Phe Ile Gln Gln Glu Met Asp Leu Leu 
         115                120                125
Arg Phe Arg Phe Ser Ile Leu Pro Lys Asp Lys Ile Gln Asp Phe Leu 
     130                135                140
Lys Asp Ser Gln Leu Gln Phe Glu Ala Ile Ser Asp Glu Glu Lys Thr 
 145                150                155                160
Leu Arg Glu Gln Glu Ile Val Ala Ser Ser Pro Ser Leu Ser Gly Leu 
                 165                170                175
Lys Leu Gly Phe Glu Ser Ile Tyr Lys Ile Pro Phe Ala Asp Ala Leu 
             180                185                190
Asp Leu Phe Arg Gly Arg Lys Val Tyr Leu Glu Asp Gly Phe Ala Tyr 
         195                200                205
Val Pro Leu Lys Asp Ile Val Ala Ile Ile Leu Asn Glu Phe Arg Ala 
     210                215                220
Lys Leu Ser Lys Ala Leu Ala Leu Thr Ala Arg Ser Leu Pro Ala Val 
 225                230                235                240
Gln Ser Asp Glu Arg Leu Gln Pro Leu Leu Asn His Leu Ser His Ser 
                 245                250                255
Tyr Thr Gly Gln Asp Tyr Ser Thr Gln Gly Asn Val Gly Lys Ile Ser 
             260                265                270
Leu Asp Gln Ile Asp Leu Leu Ser Thr Lys Ser Phe Pro Pro Cys Met 
         275                280                285
Arg Gln Leu His Lys Ala Leu Arg Glu Asn His His Leu Arg His Gly 
     290                295                300
Gly Arg Met Gln Tyr Gly Leu Phe Leu Lys Gly Ile Gly Leu Thr Leu 
 305                310                315                320
Glu Gln Ala Leu Gln Phe Trp Lys Gln Glu Phe Ile Lys Gly Lys Met 
                 325                330                335
Asp Pro Asp Lys Phe Asp Lys Gly Tyr Ser Tyr Asn Ile Arg His Ser 
             340                345                350
Phe Gly Lys Glu Gly Lys Arg Thr Asp Tyr Thr Pro Phe Ser Cys Leu 
         355                360                365
Lys Ile Ile Leu Ser Asn Pro Pro Ser Gln Gly Asp Tyr His Gly Cys 
     370                375                380
Pro Phe Arg His Ser Asp Pro Glu Leu Leu Lys Gln Lys Leu Gln Ser 
 385                390                395                400
Tyr Lys Ile Ser Pro Gly Gly Ile Ser Gln Ile Leu Asp Leu Val Lys 
                 405                410                415
Gly Thr His Tyr Gln Val Ala Cys Gln Lys Tyr Phe Glu Met Ile His 
             420                425                430
Asn Val Asp Asp Cys Gly Phe Ser Leu Asn His Pro Asn Gln Phe Phe 
         435                440                445
Cys Glu Ser Gln Arg Ile Leu Asn Gly Gly Lys Asp Ile Lys Lys Glu 
     450                455                460
Pro Ile Gln Pro Glu Thr Pro Gln Pro Lys Pro Ser Val Gln Lys Thr 
 465                470                475                480
Lys Asp Ala Ser Ser Ala Leu Ala Ser Leu Asn Ser Ser Leu Glu Met 
                 485                490                495
Asp Met Glu Gly Leu Glu Asp Tyr Phe Ser Glu Asp Ser 
             500                505



<210> 1440
<211> 1563
<212> DNA
<213> Rattus norvegicus
<308> AJ011607
<400> 1440

gtcaagatg  agttctcag  aaggacccg  aagaagctg  gattggcag  tgaccagag  60
aacgcttgt  accctcaca  ccttcagtt  tatctgcag  cacctactg  aaacatatc  120
ttgacagag  ttgaaagct  ggcttttga  agagtaaaa  tgcttaaag  aattgagaa  180
cttggtgtg  gctatgtga  aggaaccga  cagtaccag  gtaaactgg  ggctgagat  240
cgaaagctc  agttttcgt  cagggagaa  ctggaggat  agtacgagc  tcggaggag  300
gaccacatc  cccacttca  cctgcgcct  gcttactgc  agtcggaag  tcttagacg  360
tggtttatt  aacaggaga  ggatctgct  cggttccga  tcagtattt  acccaagga  420
aaagtccag  gtttcttga  ggatactca  ttgcatttt  aggctatca  tgatgagga  480
aagaccctt  gggaacagg  tatcatggc  tcctctccc  gcctaagtg  ggtcaggtg  540
gaatcggag  cagtgtata  ggtcccctt  gctgacgct  tggacctgt  cagaggaag  600
aaagtctac  tggaagacg  ctttgctta  gtgccactt  aggacattg  ggccattat  660
ctgaacgag  ttagagcca  gctgtctaa  gccttggca  taacagcca  gtccctgcc  720
gctgtgcag  ccgatgaac  acttcagcc  ctgctcagc  acctcagtc  ttcttacac  780
ggccaagat  atagtaccc  gaagagcac  gggaagatt  ccttagatc  gattgattc  840
ctttcaaca  aatccttcc  accttgcat  cgtcagctg  acaaggcgc  gagggaaaa  900
caccatctt  gtcatggag  ccggatgca  tatggcctg  tcctcaagg  cattgggct  960
acgttggag  aagcattgc  gttctggaa  caagagttt  tcaaaggaa  gatggaccc  1020
gacaagttt  ataaaggtt  ctcttacaa  atccgacat  gctttggaa  ggaaggcaa  1080
aggacagac  atacgccat  cagttgcat  aagattatc  tgaccaacc  accaagcca  1140
ggggatttc  atgggtgcc  attccgtca  agtgatgca  agctgctga  gcagaagat  1200
cagacctac  agatccctg  ctcggggat  agccagatt  tggatttgg  aaaggggaa  1260
cattaccag  tggcctgtc  gaagtactt  gagatgacg  acaatgtgg  cgattgtgg  1320
ttttctttg  atcatccaa  tcagttctt  tttgagagc  agcgaatcc  aactggtgg  1380
aaagatatc  agaaggaag  aagccaccc  gaaacgcct  agcacaaac  cagcaccca  1440
aagaccaag  atgccacgt  tgctctggc  tctctagat  cctccctgg  aatggatct  1500
gaggggcta  aagactact  tagtaaatg  cgtggcccc  ggagcaact  gagcaaata  1560
att  1563



<210> 1441
<211> 507
<212> PRT
<213> Rattus norvegicus
<308> CAA09722
<400> 1441

Met Gln Phe Ser Gly Arg Thr Arg Lys Lys Leu Arg Leu Ala Gly Asp 
  1               5                  10                  15
Gln Arg Asn Ala Cys Tyr Pro His Ser Leu Gln Phe Tyr Leu Gln Pro 
             20                  25                  30
Pro Thr Glu Asn Ile Ser Leu Thr Glu Phe Glu Ser Leu Ala Phe Asp 
         35                  40                  45
Arg Val Lys Leu Leu Lys Ala Ile Glu Asn Leu Gly Val Ser Tyr Val 
     50                  55                  60
Lys Gly Thr Glu Gln Tyr Gln Ser Lys Leu Glu Ala Glu Ile Arg Lys 
 65                  70                  75                  80
Leu Lys Phe Ser Tyr Arg Glu Asn Leu Glu Asp Glu Tyr Glu Pro Arg 
                 85                  90                  95
Arg Arg Asp His Ile Ser His Phe Ile Leu Arg Leu Ala Tyr Cys Gln 
             100                105                110
Ser Glu Asp Leu Arg Arg Trp Phe Ile Gln Gln Glu Met Asp Leu Leu 
         115                120                125
Arg Phe Arg Phe Ser Ile Leu Pro Lys Asp Lys Val Gln Ser Phe Leu 
     130                135                140
Lys Asp Thr His Leu His Phe Glu Ala Ile Ser Asp Glu Glu Lys Thr 
 145                150                155                160
Leu Arg Glu Gln Asp Ile Met Ala Ser Ser Pro Ser Leu Ser Gly Val 
                 165                170                175
Arg Trp Glu Ser Glu Ser Val Tyr Lys Val Pro Phe Ala Asp Ala Leu 
             180                185                190
Asp Leu Phe Arg Gly Arg Lys Val Tyr Leu Glu Asp Gly Phe Ala Tyr 
         195                200                205
Val Pro Leu Lys Asp Ile Val Ala Ile Ile Leu Asn Glu Phe Arg Ala 
     210                215                220
Thr Leu Ser Lys Ala Leu Ala Leu Thr Ala Arg Ser Leu Pro Ala Val 
 225                230                235                240
Gln Ser Asp Glu Arg Leu Gln Pro Leu Leu Ser His Leu Ser His Ser 
                 245                250                255
Tyr Thr Gly Gln Asp Tyr Ser Thr Gln Lys Ser Thr Gly Lys Ile Ser 
             260                265                270
Leu Asp Gln Ile Asp Ser Leu Ser Thr Lys Ser Phe Pro Pro Cys Met 
         275                280                285
Arg Gln Leu His Lys Ala Leu Arg Glu Asn His His Leu Arg His Gly 
     290                295                300
Gly Arg Met Gln Tyr Gly Leu Phe Leu Lys Gly Ile Gly Leu Thr Leu 
 305                310                315                320
Glu Gln Ala Leu Gln Phe Trp Lys Gln Glu Phe Ile Lys Gly Lys Met 
                 325                330                335
Asp Pro Asp Lys Phe Asp Lys Gly Tyr Ser Tyr Asn Ile Arg His Ser 
             340                345                350
Phe Gly Lys Glu Gly Lys Arg Thr Asp Tyr Thr Pro Phe Ser Cys Met 
         355                360                365
Lys Ile Ile Leu Thr Asn Pro Pro Ser Gln Gly Asp Phe His Gly Cys 
     370                375                380
Pro Phe Arg His Ser Asp Ala Glu Leu Leu Lys Gln Lys Met Gln Thr 
 385                390                395                400
Tyr Lys Ile Pro Ala Ser Gly Ile Ser Gln Ile Leu Asp Leu Val Lys 
                 405                410                415
Gly Asn His Tyr Gln Val Ala Cys Gln Lys Tyr Phe Glu Met Thr His 
             420                425                430
Asn Val Asp Asp Cys Gly Phe Ser Leu Asn His Pro Asn Gln Phe Phe 
         435                440                445
Phe Glu Ser Gln Arg Ile Leu Thr Gly Gly Lys Asp Ile Lys Lys Glu 
     450                455                460
Ala Ser His Pro Glu Thr Pro Gln His Lys Pro Ser Thr Gln Lys Thr 
 465                470                475                480
Lys Asp Ala Thr Ser Ala Leu Ala Ser Leu Asp Ser Ser Leu Glu Met 
                 485                490                495
Asp Leu Glu Gly Leu Glu Asp Tyr Phe Ser Lys 
             500                505



<210> 1442
<211> 2306
<212> DNA
<213> Homo sapiens
<308> NM_000947
<400> 1442

ggtttcata  gaactctcc  gccacccgg  aacagctgg  tgccaccgt  tgtgttttc  60
gagtttgta  tcttgcagg  gaccaagat  gagttttct  gaagaaagc  gaggaagct  120
aggttggca  gtgaccaga  gaatgcttc  taccctcat  gccttcagt  ttacttgca  180
ccaccttct  aaaacatat  tttaacaga  tttgaaaac  tggctattg  tagagttaa  240
ttgttaaaa  cagttgaaa  tcttggagt  agctatgtg  aaggaactg  acaatacca  300
agtaagttg  agagtgagc  tcggaagct  aagttttcc  acagagaga  gctagaaga  360
gaatatgaa  cacgaagaa  agatcatat  tctcatttt  ttttgcggc  tgcttattg  420
cagtctgaa  aacttagac  ctggttcat  caacaagaa  tggatctcc  tcgatttag  480
tttagtatt  tacccaagg  taaaattca  gatttctta  aggatagcc  attgcagtt  540
gaggctata  gtgatgaag  gaagactct  cgagaacag  agattgttg  ctcatcacc  600
agtttaagt  gacttaagt  ggggttcga  tccatttat  agatccctt  tgctgatgc  660
ctggatttg  ttcgaggaa  gaaagtcta  ttggaagat  gctttgctt  cgtaccact  720
aaggacatt  tggcaatca  cctgaatga  tttagagcc  aactgtcca  ggctttggc  780
ttaacagcc  ggtccttgc  tgctgtgca  tctgatgaa  gacttcagc  tctgctcaa  840
cacctcagt  attcctaca  tggccaaga  tacagtacc  agggaaatg  tgggaagat  900
tctttagat  agattgatt  gctttctac  aaatccttc  caccttgca  gcgtcagtt  960
cataaagcc  tgcgggaaa  tcaccatct  cgtcatgga  gccgaatgc  gtatggcct  1020
tttctgaag  gcattggtt  aactttgga  caggcattg  agttctgga  gcaagaatt  1080
atcaaagga  agatggatc  agacaagtt  gataaaggt  actcttaca  catccgtca  1140
agctttgga  aggaaggca  gaggacaga  tatacacct  tcagttgcc  gaagattat  1200
ctgtccaat  caccaagcc  aggggatta  catgggtgc  cattccgtc  cagtgatcc  1260
gagctgctg  agcaaaagt  gcagtcata  aagatctct  ctggaggga  aagccagat  1320
ttggattta  taaagggga  acattacca  gtagcctgt  aaaaatact  tgagatgat  1380
cacaatgtg  atgattgtg  cttttcttt  aatcatcct  atcagttct  ttgtgagag  1440
caacgtatt  taaatggtg  taaagacat  aagaaggaa  ctatccaac  agaaactcc  1500
caacccaaa  caagtgtcc  gaaaaccaa  gatgcatca  ctgctctgg  ctctttaaa  1560
tcctctctg  aaatggata  ggaaggact  gaagattac  ttagtgaag  ttcttaggc  1620
gttttataa  cctttttcc  caatagcct  tttcctgtt  ttaagattt  gcctttgtt  1680
ttgaaaaag  gtttcactg  caccaaggc  tagtgcagt  acacaatta  agctgattg  1740
agccttgac  ttcccagct  aagtgatcc  cctacctca  cctcccaag  agttaggac  1800
cacaggtgt  cacctcata  ccagataat  tttttcaat  tttttttgt  gaggtgggg  1860
gtctcccta  gttgcccag  cagatctca  actcctggg  tcaagcgat  ctcacacct  1920
agcgtccca  agtgctggg  ttacagttg  gagccactg  gcctggcct  ttttttttt  1980
taacctttt  gtttaactt  tctcttcac  gcatcccaa  ccatctaca  gcatgcaca  2040
ttattagga  aggaggttt  aggtaacaa  agagacttt  actatattt  gctttgaca  2100
aaggaaaga  gaggagttt  tattaaaat  tgtcacttg  gtgatgtca  ttaagtcct  2160
ttttaggag  taaaaacag  tttggggac  ggttaaagt  ccccagaaa  tacaataaa  2220
aacaacttt  gttttaact  ttaatcact  tgtaatttt  actcaatcc  tttctggac  2280
atttttgtt  ataaatatc  aagtgt  2306



<210> 1443
<211> 509
<212> PRT
<213> Homo sapiens
<308> P49643
<400> 1443

Met Glu Phe Ser Gly Arg Lys Arg Arg Lys Leu Arg Leu Ala Gly Asp 
  1               5                  10                  15
Gln Arg Asn Ala Ser Tyr Pro His Cys Leu Gln Phe Tyr Leu Gln Pro 
             20                  25                  30
Pro Ser Glu Asn Ile Ser Leu Thr Glu Phe Glu Asn Leu Ala Ile Asp 
         35                  40                  45
Arg Val Lys Leu Leu Lys Ser Val Glu Asn Leu Gly Val Ser Tyr Val 
     50                  55                  60
Lys Gly Thr Glu Gln Tyr Gln Ser Lys Leu Glu Ser Glu Leu Arg Lys 
 65                  70                  75                  80
Leu Lys Phe Ser Tyr Arg Glu Lys Leu Glu Asp Glu Tyr Glu Pro Arg 
                 85                  90                  95
Arg Arg Asp His Ile Ser His Phe Ile Leu Arg Leu Ala Tyr Cys Gln 
             100                105                110
Ser Glu Glu Leu Arg Arg Trp Phe Ile Gln Gln Glu Met Asp Leu Leu 
         115                120                125
Arg Phe Arg Phe Ser Ile Leu Pro Lys Asp Lys Ile Gln Asp Phe Leu 
     130                135                140
Lys Asp Ser Gln Leu Gln Phe Glu Ala Ile Ser Asp Glu Glu Lys Thr 
 145                150                155                160
Leu Arg Glu Gln Glu Ile Val Ala Ser Ser Pro Ser Leu Ser Gly Leu 
                 165                170                175
Lys Leu Gly Phe Glu Ser Ile Tyr Lys Ile Pro Phe Ala Asp Ala Leu 
             180                185                190
Asp Leu Phe Arg Gly Arg Lys Val Tyr Leu Glu Asp Gly Phe Ala Tyr 
         195                200                205
Val Pro Leu Lys Asp Ile Val Ala Ile Ile Leu Asn Glu Phe Arg Ala 
     210                215                220
Lys Leu Ser Lys Ala Leu Ala Leu Thr Ala Arg Ser Leu Pro Ala Val 
 225                230                235                240
Gln Ser Asp Glu Arg Leu Gln Pro Leu Leu Asn His Leu Ser His Ser 
                 245                250                255
Tyr Thr Gly Gln Asp Tyr Ser Thr Gln Gly Asn Val Gly Lys Ile Ser 
             260                265                270
Leu Asp Gln Ile Asp Leu Leu Ser Thr Lys Ser Phe Pro Pro Cys Met 
         275                280                285
Arg Gln Leu His Lys Ala Leu Arg Glu Asn His His Leu Arg His Gly 
     290                295                300
Gly Arg Met Gln Tyr Gly Leu Phe Leu Lys Gly Ile Gly Leu Thr Leu 
 305                310                315                320
Glu Gln Ala Leu Gln Phe Trp Lys Gln Glu Phe Ile Lys Gly Lys Met 
                 325                330                335
Asp Pro Asp Lys Phe Asp Lys Gly Tyr Ser Tyr Asn Ile Arg His Ser 
             340                345                350
Phe Gly Lys Glu Gly Lys Arg Thr Asp Tyr Thr Pro Phe Ser Cys Leu 
         355                360                365
Lys Ile Ile Leu Ser Asn Pro Pro Ser Gln Gly Asp Tyr His Gly Cys 
     370                375                380
Pro Phe Arg His Ser Asp Pro Glu Leu Leu Lys Gln Lys Leu Gln Ser 
 385                390                395                400
Tyr Lys Ile Ser Pro Gly Gly Ile Ser Gln Ile Leu Asp Leu Val Lys 
                 405                410                415
Gly Thr His Tyr Gln Val Ala Cys Gln Lys Tyr Phe Glu Met Ile His 
             420                425                430
Asn Val Asp Asp Cys Gly Phe Ser Leu Asn His Pro Asn Gln Phe Phe 
         435                440                445
Cys Glu Ser Gln Arg Ile Leu Asn Gly Gly Lys Asp Ile Lys Lys Glu 
     450                455                460
Pro Ile Gln Pro Glu Thr Pro Gln Pro Lys Pro Ser Val Gln Lys Thr 
 465                470                475                480
Lys Asp Ala Ser Ser Ala Leu Ala Ser Leu Asn Ser Ser Leu Glu Met 
                 485                490                495
Asp Met Glu Gly Leu Glu Asp Tyr Phe Ser Glu Asp Ser 
             500                505



<210> 1444
<211> 4128
<212> DNA
<213> Rattus norvegicus
<308> AJ012603
<400> 1444

ggttccggc  gtgggcagc  gggtggtcc  cgactgcgg  cggaagcag  ctgagcggc  60
ctcggcgag  gccgcctgt  cttccgggg  cttcagcct  gctcttgag  tttccctgt  120
ggcggcgcg  gagggaaaa  tttgcaggg  cgtgctggg  agatcacct  cgcttccca  180
tgtgagcag  ttctcgaac  ctctctcta  aaggttgcc  agagaggtg  tggacggga  240
catgaggca  cgtctcctc  tcctgacca  tttggtgcc  ttcgtcctg  caccccgac  300
tccggagga  ccaggctct  gctcccacc  gcgacttga  aagcttgat  ctttgctct  360
agactacga  atcctctct  tatctaata  ccagcagca  tccataagg  aaagggatc  420
acagtctgc  acacactta  aaacactac  aactttttc  gctttgaaa  ggcatttta  480
attatactt  acatcaagt  cagaacgct  ttcacagaa  ttgcgagtc  tggtggtgg  540
tgggaaaga  gaaagcgag  acagtgtga  gtggcagga  ttcttcagc  gacatgtgg  600
tggtgagcc  gactctagg  ttctagcgc  cataggaga  gatgatgtc  cagtaagaa  660
caacacaga  ggggcagaa  ataacatag  gccactttg  aggtttgtt  atgatacta  720
agataaaag  atgctggtg  ataagtctg  agatatcaa  gatttttca  gtttgcagt  780
tccaaaagt  tgtggttat  taaatgcag  tagtgaaga  ttgcttcca  aagggctca  840
agacagaga  ccatctgaa  agtttgtcc  tcgagtgaa  aggcgagct  aacctaacc  900
attgaagaa  acttgtaaa  tactggtgg  ggcagatca  cgattttat  agtacatgg  960
ccgaggaga  gagagcact  ctacaaatt  cttaataga  ttaattgac  gagttgatg  1020
catataccg  aacacctcg  gggacaatg  aggatttaa  ggttatgga  tacagatag  1080
acagattcg  attctcaag  ctccacaag  ggtaaaacc  ggtgaaaga  acttcaata  1140
ggcaaaaag  tttccaaat  aagaaaagg  tgcttggga  gtgaagatg  tgctggagc  1200
atttagcct  gatatagct  aagaggcct  taaagtctg  ctggctcat  ttttcacct  1260
ccaagattt  gatatggga  ctcttggat  agcttacgt  ggttctccc  gagcaaaca  1320
tcatggagg  gtttgtcca  aagcttatt  caacccagg  gtgaagaag  acatctatt  1380
gaatagtgg  ctgacaagt  caaaaaatt  tggtaaaac  atccttaca  aggaggctg  1440
cctggttac  actcatgaa  tgggacaca  ttttggagc  gaacatgat  ctgatgggc  1500
ggcagagtg  gccccaaat  aggaccaag  aggaaagta  gttatgtac  ccatagctg  1560
gagtggtga  catgagaat  ataagatgt  ttcaaactg  agtaaacag  ccatctaca  1620
gaccataga  agcaaggct  aagagtgct  ccaggagcg  agcaacaag  tgtgcggca  1680
ctccagggt  gacgaagga  aagagtgtg  cccgggcat  atgtacctg  acaacgaca  1740
ctgctgcaa  agtgactgc  cactgaagc  aggtgtgca  tgcagtgat  ggaatagtc  1800
ttgctgtaa  aattgtcag  ttgagacgg  ccagaagaa  tgccaggag  ctatcaatg  1860
tacttgcaa  ggagtgtct  actgcacag  gaatagcag  gagtgcccc  caccaggag  1920
tgctgaaga  gacactgtg  gcttggacc  gggcaagtg  aaggctggg  aatgcatcc  1980
tttctgcaa  agggagcag  agctggagt  ctgcgcatg  gctgacacc  acaactcgt  2040
caaggtatg  tgcaggaac  tttctggcc  atgtgtgcc  tacgtcgat  cagagcaaa  2100
gaacttatt  ttgaggaaa  ggaagccct  tacagtagg  ttttgtgac  tgaatggca  2160
atgtgagaa  cgggtacag  acgtaattg  gcggttttg  gatttcatt  accagctga  2220
catcaacac  tttgggaag  ttctggcag  caacatcgt  gggtctgtt  tggttttct  2280
cttgatatt  tggattcct  tcagcattc  tgtccactg  gtggataag  aactggaca  2340
gcagtatga  tccctgtct  tgtttcatc  cagtaacat  gagatgttg  gcagcatgg  2400
ctcagcatc  gttcgcatt  tcaagccgt  ccctgcacc  cagactcca  gtcgtctgc  2460
ggccctgca  ccggctgca  tgatgccgc  agtgtctgc  gctccaaaa  tggatcacc  2520
gaggatgga  accatccag  aagacccca  cacagattc  catgtggat  atgatggct  2580
tgagaagga  cccttcccc  acagcagtg  agccgccaa  tcctttgag  acctcacag  2640
ccacccagt  accaggagt  agaaggccg  ctccttcaa  ctgcagcgt  agagccgag  2700
tgatagcaa  gagacagag  gttagtggg  gcctgggcc  gctctgggg  acacagacc  2760
acagatgtt  cacagagct  acctgaatc  aaatagact  taatgatct  agaaacggg  2820
gcagcttag  agatgctgg  catgtgaca  gaccttcac  tgacatcct  tgtatgtag  2880
ccctttgaa  aggtgaggt  aatctggct  atttaaggc  ttcaggttt  ggggttttc  2940
tttgtaatc  aaaaatctc  tttgacctg  ggtgcagaa  cagaaaata  ggctggatc  3000
agttcctgg  gacagcact  attaagcct  cagtctgtt  ttctgtatg  tgtaaggtc  3060
tctcactac  gtgaagcac  tagcagtga  gataactgg  acacagact  tttgggggt  3120
ttggccttc  catgtgcgt  gtctccaaa  gccgtctgt  ttggcactg  actttgtgg  3180
tacagtcct  tccaagatg  agactagct  tggaacagt  tatacaaac  gccacatga  3240
cttcaagat  gcctattaa  tgcttagcc  caggttccc  ggacagttt  tccgttttg  3300
aaaaagtgt  ttcacgggt  tctaaacat  gtttgtctt  aaaaatact  ggctggaga  3360
ttggcccca  agttaagag  acttggttt  attcccagt  cccacacgg  ggctcttaa  3420
tccaatccc  ggggagatg  catcttctg  actctagaa  acaaggcat  cattggtgc  3480
gtcaaacat  caggcaaca  acacaaatt  agaaagcca  gtgctgtaa  aagttgcac  3540
tcccccaac  tacagtgct  cgcggtctg  gctggagtg  agctctctc  tgaacactc  3600
ggaaggctg  caggtgctg  gctggctag  gagacgggt  gggcccagc  ctggaagaa  3660
cgtcttcag  ctcagcaag  agacactcg  gttacctca  gctttgggg  ttcaggacc  3720
aggatgttt  gtacttatt  tgtgaggat  aataccatt  gcctgaatt  tcatttctg  3780
aagttttag  tataaaagc  ttttttctt  taagaattg  aatgtgctc  ccagcaaac  3840
cgtcttaac  agaataact  gtaactctg  ggacagtta  ccaaacctg  gccttgtct  3900
tcctgaggg  gtctgttac  ctaatactt  aacatgtac  ttgtggtat  ggctccttt  3960
actagtcat  acagcctta  atgttagtt  cactttgag  atttgctct  aggtgagtg  4020
ggtgtgtgg  tgtatgtat  aatgaaaca  ttggcagaa  ataagaaaa  catttttat  4080
aaattgtga  tttttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4128



<210> 1445
<211> 827
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1K9
<400> 1445

Met Arg Gln Arg Leu Leu Phe Leu Thr Thr Leu Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Glu Glu Pro Gly Ser Gly Ser His Leu Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Ile Arg Lys Arg Asp Leu Gln Ser Ala Thr 
     50                  55                  60
His Leu Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Leu Arg Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Glu Glu Ser Glu Tyr Ser Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Ser Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Gly Asp Asp Asp Val Thr Val Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asp Phe Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Asn Ala Asp Ser Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Ile Asp Arg Glu Pro Ser Glu Glu Phe 
         195                200                205
Val Arg Arg Val Lys Arg Arg Ala Glu Pro Asn Pro Leu Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Lys Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Val Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Arg His Phe Asn Met Ala Lys Ser Phe 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Leu Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Asn Pro Gly Val Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Pro Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asp 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Ala Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Lys Arg Glu Gln Glu Leu Glu Ser Cys Ala 
             580                585                590
Cys Ala Asp Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asn Leu Ser 
         595                600                605
Gly Pro Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His His Ser Asn Ile Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Ala Leu Gln Pro Ala Ala Met Met Pro Pro Val Ser 
             740                745                750
Ala Ala Pro Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp 
         755                760                765
Pro Ser Thr Asp Ser His Val Asp Asp Asp Gly Phe Glu Lys Asp Pro 
     770                775                780
Phe Pro Asn Ser Ser Ala Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp 
 785                790                795                800
His Pro Val Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg 
                 805                810                815
Gln Ser Arg Val Asp Ser Lys Glu Thr Glu Cys 
             820                825



<210> 1446
<211> 2877
<212> DNA
<213> Homo sapiens
<308> U69612
<400> 1446

ggaaaagag  attgagggg  taggccggg  ggatcccgt  ctcccccga  gtgagcagt  60
ttccgaaac  ccgtcaggc  aaggctgcc  agagaggtg  agtcggtag  ggggccggg  120
acatgaggc  gtctctcct  ttcctgacc  gcgtggttc  tttcgtgct  gcgccgcga  180
ctccggatg  cccgggctt  ggcccccac  agagactcg  gaagcttga  tctttgctc  240
cagactacg  tattctctc  ttatctaat  tccagcagc  ttcggtaag  aaaagagat  300
tacagactt  aacacatgt  gaaacacta  taacttttt  agctttgaa  aggcatttt  360
aattatacc  gacatcaag  actgaacgt  tttcacaaa  tttcaaggt  gtggtggtg  420
atggtaaaa  cgaaagcga  tacactgta  aatggcagg  cttcttcac  ggacacgtg  480
ttggtgagc  tgactctag  gttctagcc  acataagag  tgatgatgt  ataatcaga  540
tcaacacag  tggggccga  tataacata  agccacttt  gagatttgt  aatgatacc  600
aagacaaaa  aatgttagt  tataaatct  aagatatca  gaatgtttc  cgtttgcag  660
ctccaaaag  gtgtggtta  ttaaaagtg  ataatgaag  gttgctccc  aaagggtta  720
tagacagag  accacctga  gagcttgtt  atcgagtga  aagaagagc  gacccagat  780
ccatgaaga  cacgtgtaa  ttattggtg  tagcagatc  tcgcttcta  agatacatg  840
gcagagggg  agagagtac  actacaaat  acttaatag  gctaattga  agagttgat  900
acatctatc  gaacacttc  tgggataat  caggtttta  aggctatgg  atacagata  960
agcagattc  cattctcaa  tctccacaa  aggtaaaac  tggtgaaaa  cactacaac  1020
tggcaaaaa  ttacccaaa  gaagaaaag  atgcttggg  tgtgaagat  ttgctagag  1080
aatttagct  tgatatagc  gaggaagca  ctaaagttt  cttggcaca  cttttcaca  1140
accaagatt  tgatatggg  actcttgga  tagcttatg  tggctctcc  agagcaaac  1200
gccatggag  tgtttgtcc  aaggcttat  atagcccag  tgggaagaa  aatatctat  1260
tgaatagtg  tttgacgag  acaaagaat  atggtaaaa  catccttac  aaggaagct  1320
acctggtta  aactcatga  ttgggacat  attttggag  agaacatga  ccggatggt  1380
tagcagaat  tgccccgaa  gaggaccag  gagggaaat  tgtcatgta  cccatagct  1440
tgagtggcg  tcacgagaa  aataagatg  tttcaaact  cagtaaaca  tcaatctat  1500
agaccattg  aagtaaggc  caggagtgt  ttcaagaac  cagcaataa  gtttgtggg  1560
actcgaggg  ggatgaagg  gaagagtgt  atcctggca  catgtatct  aacaacgac  1620
cctgctgca  cagcgactg  acgttgaag  aaggtgtcc  gtgcagtga  aggaacagt  1680
cttgctgta  aaactgtca  tttgagact  cccagaaga  gtgccagga  gcgattaat  1740
ctacttgca  aggcgtgtc  tactgcaca  gtaatagca  tgagtgccc  cctccagga  1800
atgctgaag  tgacactgt  tgcttggat  ttggcaagt  taaggatgg  aaatgcatc  1860
ctttctgcg  gagggaaca  cagctggag  cctgtgcat  taatgaaac  gacaactcc  1920
gcaaggtgt  ctgcaggga  ctttccggc  gctgtgtgc  ctatgtcga  gctgaacaa  1980
agaacttat  tttgaggaa  ggaaagccc  gtacagtag  attttgtga  atgaatggc  2040
aatgtgaga  acgagtaca  gatgtaatt  aacgatttt  ggatttcat  gaccagctg  2100
gcatcaata  ttttggaaa  tttttagca  acaacatcg  tgggtctgt  ctggttttc  2160
ccttgatat  ttggattcc  ttcagcatt  ttgtccatt  tgtgtaacg  cgaaatgct  2220
agcagcatg  attctgcat  ggttcgcat  atcaaaccc  ttcctgcgc  ccagactcc  2280
ggccgcctg  agcctgccc  tgtgatccc  tcggcgcca  cagctccaa  actggacca  2340
cagagaatg  acaccatcc  ggaagaccc  agcacagac  cacatatgg  cgaggatgg  2400
tttgagaag  accccttcc  aaatagcag  acagctgcc  agtcatttg  ggatctcac  2460
gaccatccg  tcaccagaa  tgaaaaggc  gcctccttt  aactgcagc  tcagaatcg  2520
gttgacagc  aagaaacag  gtgctaatt  agttctcag  tcttctgac  taagtgtgc  2580
aaatatttt  atagatttg  cctacaatc  atcacagct  atattttgt  aagactggg  2640
agtgactta  cagatgctg  tcatgtgtt  gaacttcct  caggtaaac  gttcttgtg  2700
ggtttggcc  ttctccttt  gaaaaggta  ggtgaaggt  aatctagct  attttgagg  2760
tttcaggtt  tagttttta  aatatcttt  gacctgtgg  gcaaaagca  aaaatacag  2820
tggattggg  tatgagtat  tacgttttt  taaattaat  ttttatatt  ataacag  2877



<210> 1447
<211> 824
<212> PRT
<213> Homo sapiens
<308> P78536
<400> 1447

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
     50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
         195                200                205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
             580                585                590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
         595                600                605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
             740                745                750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
         755                760                765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
     770                775                780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
 785                790                795                800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                 805                810                815
Val Asp Ser Lys Glu Thr Glu Cys 
             820



<210> 1448
<211> 4128
<212> DNA
<213> Rattus norvegicus
<308> AJ012603
<400> 1448

ggttccggc  gtgggcagc  gggtggtcc  cgactgcgg  cggaagcag  ctgagcggc  60
ctcggcgag  gccgcctgt  cttccgggg  cttcagcct  gctcttgag  tttccctgt  120
ggcggcgcg  gagggaaaa  tttgcaggg  cgtgctggg  agatcacct  cgcttccca  180
tgtgagcag  ttctcgaac  ctctctcta  aaggttgcc  agagaggtg  tggacggga  240
catgaggca  cgtctcctc  tcctgacca  tttggtgcc  ttcgtcctg  caccccgac  300
tccggagga  ccaggctct  gctcccacc  gcgacttga  aagcttgat  ctttgctct  360
agactacga  atcctctct  tatctaata  ccagcagca  tccataagg  aaagggatc  420
acagtctgc  acacactta  aaacactac  aactttttc  gctttgaaa  ggcatttta  480
attatactt  acatcaagt  cagaacgct  ttcacagaa  ttgcgagtc  tggtggtgg  540
tgggaaaga  gaaagcgag  acagtgtga  gtggcagga  ttcttcagc  gacatgtgg  600
tggtgagcc  gactctagg  ttctagcgc  cataggaga  gatgatgtc  cagtaagaa  660
caacacaga  ggggcagaa  ataacatag  gccactttg  aggtttgtt  atgatacta  720
agataaaag  atgctggtg  ataagtctg  agatatcaa  gatttttca  gtttgcagt  780
tccaaaagt  tgtggttat  taaatgcag  tagtgaaga  ttgcttcca  aagggctca  840
agacagaga  ccatctgaa  agtttgtcc  tcgagtgaa  aggcgagct  aacctaacc  900
attgaagaa  acttgtaaa  tactggtgg  ggcagatca  cgattttat  agtacatgg  960
ccgaggaga  gagagcact  ctacaaatt  cttaataga  ttaattgac  gagttgatg  1020
catataccg  aacacctcg  gggacaatg  aggatttaa  ggttatgga  tacagatag  1080
acagattcg  attctcaag  ctccacaag  ggtaaaacc  ggtgaaaga  acttcaata  1140
ggcaaaaag  tttccaaat  aagaaaagg  tgcttggga  gtgaagatg  tgctggagc  1200
atttagcct  gatatagct  aagaggcct  taaagtctg  ctggctcat  ttttcacct  1260
ccaagattt  gatatggga  ctcttggat  agcttacgt  ggttctccc  gagcaaaca  1320
tcatggagg  gtttgtcca  aagcttatt  caacccagg  gtgaagaag  acatctatt  1380
gaatagtgg  ctgacaagt  caaaaaatt  tggtaaaac  atccttaca  aggaggctg  1440
cctggttac  actcatgaa  tgggacaca  ttttggagc  gaacatgat  ctgatgggc  1500
ggcagagtg  gccccaaat  aggaccaag  aggaaagta  gttatgtac  ccatagctg  1560
gagtggtga  catgagaat  ataagatgt  ttcaaactg  agtaaacag  ccatctaca  1620
gaccataga  agcaaggct  aagagtgct  ccaggagcg  agcaacaag  tgtgcggca  1680
ctccagggt  gacgaagga  aagagtgtg  cccgggcat  atgtacctg  acaacgaca  1740
ctgctgcaa  agtgactgc  cactgaagc  aggtgtgca  tgcagtgat  ggaatagtc  1800
ttgctgtaa  aattgtcag  ttgagacgg  ccagaagaa  tgccaggag  ctatcaatg  1860
tacttgcaa  ggagtgtct  actgcacag  gaatagcag  gagtgcccc  caccaggag  1920
tgctgaaga  gacactgtg  gcttggacc  gggcaagtg  aaggctggg  aatgcatcc  1980
tttctgcaa  agggagcag  agctggagt  ctgcgcatg  gctgacacc  acaactcgt  2040
caaggtatg  tgcaggaac  tttctggcc  atgtgtgcc  tacgtcgat  cagagcaaa  2100
gaacttatt  ttgaggaaa  ggaagccct  tacagtagg  ttttgtgac  tgaatggca  2160
atgtgagaa  cgggtacag  acgtaattg  gcggttttg  gatttcatt  accagctga  2220
catcaacac  tttgggaag  ttctggcag  caacatcgt  gggtctgtt  tggttttct  2280
cttgatatt  tggattcct  tcagcattc  tgtccactg  gtggataag  aactggaca  2340
gcagtatga  tccctgtct  tgtttcatc  cagtaacat  gagatgttg  gcagcatgg  2400
ctcagcatc  gttcgcatt  tcaagccgt  ccctgcacc  cagactcca  gtcgtctgc  2460
ggccctgca  ccggctgca  tgatgccgc  agtgtctgc  gctccaaaa  tggatcacc  2520
gaggatgga  accatccag  aagacccca  cacagattc  catgtggat  atgatggct  2580
tgagaagga  cccttcccc  acagcagtg  agccgccaa  tcctttgag  acctcacag  2640
ccacccagt  accaggagt  agaaggccg  ctccttcaa  ctgcagcgt  agagccgag  2700
tgatagcaa  gagacagag  gttagtggg  gcctgggcc  gctctgggg  acacagacc  2760
acagatgtt  cacagagct  acctgaatc  aaatagact  taatgatct  agaaacggg  2820
gcagcttag  agatgctgg  catgtgaca  gaccttcac  tgacatcct  tgtatgtag  2880
ccctttgaa  aggtgaggt  aatctggct  atttaaggc  ttcaggttt  ggggttttc  2940
tttgtaatc  aaaaatctc  tttgacctg  ggtgcagaa  cagaaaata  ggctggatc  3000
agttcctgg  gacagcact  attaagcct  cagtctgtt  ttctgtatg  tgtaaggtc  3060
tctcactac  gtgaagcac  tagcagtga  gataactgg  acacagact  tttgggggt  3120
ttggccttc  catgtgcgt  gtctccaaa  gccgtctgt  ttggcactg  actttgtgg  3180
tacagtcct  tccaagatg  agactagct  tggaacagt  tatacaaac  gccacatga  3240
cttcaagat  gcctattaa  tgcttagcc  caggttccc  ggacagttt  tccgttttg  3300
aaaaagtgt  ttcacgggt  tctaaacat  gtttgtctt  aaaaatact  ggctggaga  3360
ttggcccca  agttaagag  acttggttt  attcccagt  cccacacgg  ggctcttaa  3420
tccaatccc  ggggagatg  catcttctg  actctagaa  acaaggcat  cattggtgc  3480
gtcaaacat  caggcaaca  acacaaatt  agaaagcca  gtgctgtaa  aagttgcac  3540
tcccccaac  tacagtgct  cgcggtctg  gctggagtg  agctctctc  tgaacactc  3600
ggaaggctg  caggtgctg  gctggctag  gagacgggt  gggcccagc  ctggaagaa  3660
cgtcttcag  ctcagcaag  agacactcg  gttacctca  gctttgggg  ttcaggacc  3720
aggatgttt  gtacttatt  tgtgaggat  aataccatt  gcctgaatt  tcatttctg  3780
aagttttag  tataaaagc  ttttttctt  taagaattg  aatgtgctc  ccagcaaac  3840
cgtcttaac  agaataact  gtaactctg  ggacagtta  ccaaacctg  gccttgtct  3900
tcctgaggg  gtctgttac  ctaatactt  aacatgtac  ttgtggtat  ggctccttt  3960
actagtcat  acagcctta  atgttagtt  cactttgag  atttgctct  aggtgagtg  4020
ggtgtgtgg  tgtatgtat  aatgaaaca  ttggcagaa  ataagaaaa  catttttat  4080
aaattgtga  tttttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4128



<210> 1449
<211> 827
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1K9
<400> 1449

Met Arg Gln Arg Leu Leu Phe Leu Thr Thr Leu Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Glu Glu Pro Gly Ser Gly Ser His Leu Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Ile Arg Lys Arg Asp Leu Gln Ser Ala Thr 
     50                  55                  60
His Leu Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Leu Arg Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Glu Glu Ser Glu Tyr Ser Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Ser Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Gly Asp Asp Asp Val Thr Val Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asp Phe Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Asn Ala Asp Ser Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Ile Asp Arg Glu Pro Ser Glu Glu Phe 
         195                200                205
Val Arg Arg Val Lys Arg Arg Ala Glu Pro Asn Pro Leu Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Lys Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Val Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Arg His Phe Asn Met Ala Lys Ser Phe 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Leu Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Asn Pro Gly Val Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Pro Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asp 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Ala Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Lys Arg Glu Gln Glu Leu Glu Ser Cys Ala 
             580                585                590
Cys Ala Asp Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asn Leu Ser 
         595                600                605
Gly Pro Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His His Ser Asn Ile Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Ala Leu Gln Pro Ala Ala Met Met Pro Pro Val Ser 
             740                745                750
Ala Ala Pro Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp 
         755                760                765
Pro Ser Thr Asp Ser His Val Asp Asp Asp Gly Phe Glu Lys Asp Pro 
     770                775                780
Phe Pro Asn Ser Ser Ala Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp 
 785                790                795                800
His Pro Val Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg 
                 805                810                815
Gln Ser Arg Val Asp Ser Lys Glu Thr Glu Cys 
             820                825



<210> 1450
<211> 2877
<212> DNA
<213> Homo sapiens
<308> U69612
<400> 1450

ggaaaagag  attgagggg  taggccggg  ggatcccgt  ctcccccga  gtgagcagt  60
ttccgaaac  ccgtcaggc  aaggctgcc  agagaggtg  agtcggtag  ggggccggg  120
acatgaggc  gtctctcct  ttcctgacc  gcgtggttc  tttcgtgct  gcgccgcga  180
ctccggatg  cccgggctt  ggcccccac  agagactcg  gaagcttga  tctttgctc  240
cagactacg  tattctctc  ttatctaat  tccagcagc  ttcggtaag  aaaagagat  300
tacagactt  aacacatgt  gaaacacta  taacttttt  agctttgaa  aggcatttt  360
aattatacc  gacatcaag  actgaacgt  tttcacaaa  tttcaaggt  gtggtggtg  420
atggtaaaa  cgaaagcga  tacactgta  aatggcagg  cttcttcac  ggacacgtg  480
ttggtgagc  tgactctag  gttctagcc  acataagag  tgatgatgt  ataatcaga  540
tcaacacag  tggggccga  tataacata  agccacttt  gagatttgt  aatgatacc  600
aagacaaaa  aatgttagt  tataaatct  aagatatca  gaatgtttc  cgtttgcag  660
ctccaaaag  gtgtggtta  ttaaaagtg  ataatgaag  gttgctccc  aaagggtta  720
tagacagag  accacctga  gagcttgtt  atcgagtga  aagaagagc  gacccagat  780
ccatgaaga  cacgtgtaa  ttattggtg  tagcagatc  tcgcttcta  agatacatg  840
gcagagggg  agagagtac  actacaaat  acttaatag  gctaattga  agagttgat  900
acatctatc  gaacacttc  tgggataat  caggtttta  aggctatgg  atacagata  960
agcagattc  cattctcaa  tctccacaa  aggtaaaac  tggtgaaaa  cactacaac  1020
tggcaaaaa  ttacccaaa  gaagaaaag  atgcttggg  tgtgaagat  ttgctagag  1080
aatttagct  tgatatagc  gaggaagca  ctaaagttt  cttggcaca  cttttcaca  1140
accaagatt  tgatatggg  actcttgga  tagcttatg  tggctctcc  agagcaaac  1200
gccatggag  tgtttgtcc  aaggcttat  atagcccag  tgggaagaa  aatatctat  1260
tgaatagtg  tttgacgag  acaaagaat  atggtaaaa  catccttac  aaggaagct  1320
acctggtta  aactcatga  ttgggacat  attttggag  agaacatga  ccggatggt  1380
tagcagaat  tgccccgaa  gaggaccag  gagggaaat  tgtcatgta  cccatagct  1440
tgagtggcg  tcacgagaa  aataagatg  tttcaaact  cagtaaaca  tcaatctat  1500
agaccattg  aagtaaggc  caggagtgt  ttcaagaac  cagcaataa  gtttgtggg  1560
actcgaggg  ggatgaagg  gaagagtgt  atcctggca  catgtatct  aacaacgac  1620
cctgctgca  cagcgactg  acgttgaag  aaggtgtcc  gtgcagtga  aggaacagt  1680
cttgctgta  aaactgtca  tttgagact  cccagaaga  gtgccagga  gcgattaat  1740
ctacttgca  aggcgtgtc  tactgcaca  gtaatagca  tgagtgccc  cctccagga  1800
atgctgaag  tgacactgt  tgcttggat  ttggcaagt  taaggatgg  aaatgcatc  1860
ctttctgcg  gagggaaca  cagctggag  cctgtgcat  taatgaaac  gacaactcc  1920
gcaaggtgt  ctgcaggga  ctttccggc  gctgtgtgc  ctatgtcga  gctgaacaa  1980
agaacttat  tttgaggaa  ggaaagccc  gtacagtag  attttgtga  atgaatggc  2040
aatgtgaga  acgagtaca  gatgtaatt  aacgatttt  ggatttcat  gaccagctg  2100
gcatcaata  ttttggaaa  tttttagca  acaacatcg  tgggtctgt  ctggttttc  2160
ccttgatat  ttggattcc  ttcagcatt  ttgtccatt  tgtgtaacg  cgaaatgct  2220
agcagcatg  attctgcat  ggttcgcat  atcaaaccc  ttcctgcgc  ccagactcc  2280
ggccgcctg  agcctgccc  tgtgatccc  tcggcgcca  cagctccaa  actggacca  2340
cagagaatg  acaccatcc  ggaagaccc  agcacagac  cacatatgg  cgaggatgg  2400
tttgagaag  accccttcc  aaatagcag  acagctgcc  agtcatttg  ggatctcac  2460
gaccatccg  tcaccagaa  tgaaaaggc  gcctccttt  aactgcagc  tcagaatcg  2520
gttgacagc  aagaaacag  gtgctaatt  agttctcag  tcttctgac  taagtgtgc  2580
aaatatttt  atagatttg  cctacaatc  atcacagct  atattttgt  aagactggg  2640
agtgactta  cagatgctg  tcatgtgtt  gaacttcct  caggtaaac  gttcttgtg  2700
ggtttggcc  ttctccttt  gaaaaggta  ggtgaaggt  aatctagct  attttgagg  2760
tttcaggtt  tagttttta  aatatcttt  gacctgtgg  gcaaaagca  aaaatacag  2820
tggattggg  tatgagtat  tacgttttt  taaattaat  ttttatatt  ataacag  2877



<210> 1451
<211> 824
<212> PRT
<213> Homo sapiens
<308> P78536
<400> 1451

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
     50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
         195                200                205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
             580                585                590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
         595                600                605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
             740                745                750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
         755                760                765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
     770                775                780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
 785                790                795                800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                 805                810                815
Val Asp Ser Lys Glu Thr Glu Cys 
             820



<210> 1452
<211> 4128
<212> DNA
<213> Rattus norvegicus
<308> AJ012603
<400> 1452

ggttccggc  gtgggcagc  gggtggtcc  cgactgcgg  cggaagcag  ctgagcggc  60
ctcggcgag  gccgcctgt  cttccgggg  cttcagcct  gctcttgag  tttccctgt  120
ggcggcgcg  gagggaaaa  tttgcaggg  cgtgctggg  agatcacct  cgcttccca  180
tgtgagcag  ttctcgaac  ctctctcta  aaggttgcc  agagaggtg  tggacggga  240
catgaggca  cgtctcctc  tcctgacca  tttggtgcc  ttcgtcctg  caccccgac  300
tccggagga  ccaggctct  gctcccacc  gcgacttga  aagcttgat  ctttgctct  360
agactacga  atcctctct  tatctaata  ccagcagca  tccataagg  aaagggatc  420
acagtctgc  acacactta  aaacactac  aactttttc  gctttgaaa  ggcatttta  480
attatactt  acatcaagt  cagaacgct  ttcacagaa  ttgcgagtc  tggtggtgg  540
tgggaaaga  gaaagcgag  acagtgtga  gtggcagga  ttcttcagc  gacatgtgg  600
tggtgagcc  gactctagg  ttctagcgc  cataggaga  gatgatgtc  cagtaagaa  660
caacacaga  ggggcagaa  ataacatag  gccactttg  aggtttgtt  atgatacta  720
agataaaag  atgctggtg  ataagtctg  agatatcaa  gatttttca  gtttgcagt  780
tccaaaagt  tgtggttat  taaatgcag  tagtgaaga  ttgcttcca  aagggctca  840
agacagaga  ccatctgaa  agtttgtcc  tcgagtgaa  aggcgagct  aacctaacc  900
attgaagaa  acttgtaaa  tactggtgg  ggcagatca  cgattttat  agtacatgg  960
ccgaggaga  gagagcact  ctacaaatt  cttaataga  ttaattgac  gagttgatg  1020
catataccg  aacacctcg  gggacaatg  aggatttaa  ggttatgga  tacagatag  1080
acagattcg  attctcaag  ctccacaag  ggtaaaacc  ggtgaaaga  acttcaata  1140
ggcaaaaag  tttccaaat  aagaaaagg  tgcttggga  gtgaagatg  tgctggagc  1200
atttagcct  gatatagct  aagaggcct  taaagtctg  ctggctcat  ttttcacct  1260
ccaagattt  gatatggga  ctcttggat  agcttacgt  ggttctccc  gagcaaaca  1320
tcatggagg  gtttgtcca  aagcttatt  caacccagg  gtgaagaag  acatctatt  1380
gaatagtgg  ctgacaagt  caaaaaatt  tggtaaaac  atccttaca  aggaggctg  1440
cctggttac  actcatgaa  tgggacaca  ttttggagc  gaacatgat  ctgatgggc  1500
ggcagagtg  gccccaaat  aggaccaag  aggaaagta  gttatgtac  ccatagctg  1560
gagtggtga  catgagaat  ataagatgt  ttcaaactg  agtaaacag  ccatctaca  1620
gaccataga  agcaaggct  aagagtgct  ccaggagcg  agcaacaag  tgtgcggca  1680
ctccagggt  gacgaagga  aagagtgtg  cccgggcat  atgtacctg  acaacgaca  1740
ctgctgcaa  agtgactgc  cactgaagc  aggtgtgca  tgcagtgat  ggaatagtc  1800
ttgctgtaa  aattgtcag  ttgagacgg  ccagaagaa  tgccaggag  ctatcaatg  1860
tacttgcaa  ggagtgtct  actgcacag  gaatagcag  gagtgcccc  caccaggag  1920
tgctgaaga  gacactgtg  gcttggacc  gggcaagtg  aaggctggg  aatgcatcc  1980
tttctgcaa  agggagcag  agctggagt  ctgcgcatg  gctgacacc  acaactcgt  2040
caaggtatg  tgcaggaac  tttctggcc  atgtgtgcc  tacgtcgat  cagagcaaa  2100
gaacttatt  ttgaggaaa  ggaagccct  tacagtagg  ttttgtgac  tgaatggca  2160
atgtgagaa  cgggtacag  acgtaattg  gcggttttg  gatttcatt  accagctga  2220
catcaacac  tttgggaag  ttctggcag  caacatcgt  gggtctgtt  tggttttct  2280
cttgatatt  tggattcct  tcagcattc  tgtccactg  gtggataag  aactggaca  2340
gcagtatga  tccctgtct  tgtttcatc  cagtaacat  gagatgttg  gcagcatgg  2400
ctcagcatc  gttcgcatt  tcaagccgt  ccctgcacc  cagactcca  gtcgtctgc  2460
ggccctgca  ccggctgca  tgatgccgc  agtgtctgc  gctccaaaa  tggatcacc  2520
gaggatgga  accatccag  aagacccca  cacagattc  catgtggat  atgatggct  2580
tgagaagga  cccttcccc  acagcagtg  agccgccaa  tcctttgag  acctcacag  2640
ccacccagt  accaggagt  agaaggccg  ctccttcaa  ctgcagcgt  agagccgag  2700
tgatagcaa  gagacagag  gttagtggg  gcctgggcc  gctctgggg  acacagacc  2760
acagatgtt  cacagagct  acctgaatc  aaatagact  taatgatct  agaaacggg  2820
gcagcttag  agatgctgg  catgtgaca  gaccttcac  tgacatcct  tgtatgtag  2880
ccctttgaa  aggtgaggt  aatctggct  atttaaggc  ttcaggttt  ggggttttc  2940
tttgtaatc  aaaaatctc  tttgacctg  ggtgcagaa  cagaaaata  ggctggatc  3000
agttcctgg  gacagcact  attaagcct  cagtctgtt  ttctgtatg  tgtaaggtc  3060
tctcactac  gtgaagcac  tagcagtga  gataactgg  acacagact  tttgggggt  3120
ttggccttc  catgtgcgt  gtctccaaa  gccgtctgt  ttggcactg  actttgtgg  3180
tacagtcct  tccaagatg  agactagct  tggaacagt  tatacaaac  gccacatga  3240
cttcaagat  gcctattaa  tgcttagcc  caggttccc  ggacagttt  tccgttttg  3300
aaaaagtgt  ttcacgggt  tctaaacat  gtttgtctt  aaaaatact  ggctggaga  3360
ttggcccca  agttaagag  acttggttt  attcccagt  cccacacgg  ggctcttaa  3420
tccaatccc  ggggagatg  catcttctg  actctagaa  acaaggcat  cattggtgc  3480
gtcaaacat  caggcaaca  acacaaatt  agaaagcca  gtgctgtaa  aagttgcac  3540
tcccccaac  tacagtgct  cgcggtctg  gctggagtg  agctctctc  tgaacactc  3600
ggaaggctg  caggtgctg  gctggctag  gagacgggt  gggcccagc  ctggaagaa  3660
cgtcttcag  ctcagcaag  agacactcg  gttacctca  gctttgggg  ttcaggacc  3720
aggatgttt  gtacttatt  tgtgaggat  aataccatt  gcctgaatt  tcatttctg  3780
aagttttag  tataaaagc  ttttttctt  taagaattg  aatgtgctc  ccagcaaac  3840
cgtcttaac  agaataact  gtaactctg  ggacagtta  ccaaacctg  gccttgtct  3900
tcctgaggg  gtctgttac  ctaatactt  aacatgtac  ttgtggtat  ggctccttt  3960
actagtcat  acagcctta  atgttagtt  cactttgag  atttgctct  aggtgagtg  4020
ggtgtgtgg  tgtatgtat  aatgaaaca  ttggcagaa  ataagaaaa  catttttat  4080
aaattgtga  tttttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4128



<210> 1453
<211> 827
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1K9
<400> 1453

Met Arg Gln Arg Leu Leu Phe Leu Thr Thr Leu Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Glu Glu Pro Gly Ser Gly Ser His Leu Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Ile Arg Lys Arg Asp Leu Gln Ser Ala Thr 
     50                  55                  60
His Leu Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Leu Arg Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Glu Glu Ser Glu Tyr Ser Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Ser Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Gly Asp Asp Asp Val Thr Val Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asp Phe Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Asn Ala Asp Ser Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Ile Asp Arg Glu Pro Ser Glu Glu Phe 
         195                200                205
Val Arg Arg Val Lys Arg Arg Ala Glu Pro Asn Pro Leu Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Lys Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Val Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Arg His Phe Asn Met Ala Lys Ser Phe 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Leu Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Asn Pro Gly Val Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Pro Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asp 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Ala Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Lys Arg Glu Gln Glu Leu Glu Ser Cys Ala 
             580                585                590
Cys Ala Asp Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asn Leu Ser 
         595                600                605
Gly Pro Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His His Ser Asn Ile Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Ala Leu Gln Pro Ala Ala Met Met Pro Pro Val Ser 
             740                745                750
Ala Ala Pro Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp 
         755                760                765
Pro Ser Thr Asp Ser His Val Asp Asp Asp Gly Phe Glu Lys Asp Pro 
     770                775                780
Phe Pro Asn Ser Ser Ala Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp 
 785                790                795                800
His Pro Val Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg 
                 805                810                815
Gln Ser Arg Val Asp Ser Lys Glu Thr Glu Cys 
             820                825



<210> 1454
<211> 2877
<212> DNA
<213> Homo sapiens
<308> U69612
<400> 1454

ggaaaagag  attgagggg  taggccggg  ggatcccgt  ctcccccga  gtgagcagt  60
ttccgaaac  ccgtcaggc  aaggctgcc  agagaggtg  agtcggtag  ggggccggg  120
acatgaggc  gtctctcct  ttcctgacc  gcgtggttc  tttcgtgct  gcgccgcga  180
ctccggatg  cccgggctt  ggcccccac  agagactcg  gaagcttga  tctttgctc  240
cagactacg  tattctctc  ttatctaat  tccagcagc  ttcggtaag  aaaagagat  300
tacagactt  aacacatgt  gaaacacta  taacttttt  agctttgaa  aggcatttt  360
aattatacc  gacatcaag  actgaacgt  tttcacaaa  tttcaaggt  gtggtggtg  420
atggtaaaa  cgaaagcga  tacactgta  aatggcagg  cttcttcac  ggacacgtg  480
ttggtgagc  tgactctag  gttctagcc  acataagag  tgatgatgt  ataatcaga  540
tcaacacag  tggggccga  tataacata  agccacttt  gagatttgt  aatgatacc  600
aagacaaaa  aatgttagt  tataaatct  aagatatca  gaatgtttc  cgtttgcag  660
ctccaaaag  gtgtggtta  ttaaaagtg  ataatgaag  gttgctccc  aaagggtta  720
tagacagag  accacctga  gagcttgtt  atcgagtga  aagaagagc  gacccagat  780
ccatgaaga  cacgtgtaa  ttattggtg  tagcagatc  tcgcttcta  agatacatg  840
gcagagggg  agagagtac  actacaaat  acttaatag  gctaattga  agagttgat  900
acatctatc  gaacacttc  tgggataat  caggtttta  aggctatgg  atacagata  960
agcagattc  cattctcaa  tctccacaa  aggtaaaac  tggtgaaaa  cactacaac  1020
tggcaaaaa  ttacccaaa  gaagaaaag  atgcttggg  tgtgaagat  ttgctagag  1080
aatttagct  tgatatagc  gaggaagca  ctaaagttt  cttggcaca  cttttcaca  1140
accaagatt  tgatatggg  actcttgga  tagcttatg  tggctctcc  agagcaaac  1200
gccatggag  tgtttgtcc  aaggcttat  atagcccag  tgggaagaa  aatatctat  1260
tgaatagtg  tttgacgag  acaaagaat  atggtaaaa  catccttac  aaggaagct  1320
acctggtta  aactcatga  ttgggacat  attttggag  agaacatga  ccggatggt  1380
tagcagaat  tgccccgaa  gaggaccag  gagggaaat  tgtcatgta  cccatagct  1440
tgagtggcg  tcacgagaa  aataagatg  tttcaaact  cagtaaaca  tcaatctat  1500
agaccattg  aagtaaggc  caggagtgt  ttcaagaac  cagcaataa  gtttgtggg  1560
actcgaggg  ggatgaagg  gaagagtgt  atcctggca  catgtatct  aacaacgac  1620
cctgctgca  cagcgactg  acgttgaag  aaggtgtcc  gtgcagtga  aggaacagt  1680
cttgctgta  aaactgtca  tttgagact  cccagaaga  gtgccagga  gcgattaat  1740
ctacttgca  aggcgtgtc  tactgcaca  gtaatagca  tgagtgccc  cctccagga  1800
atgctgaag  tgacactgt  tgcttggat  ttggcaagt  taaggatgg  aaatgcatc  1860
ctttctgcg  gagggaaca  cagctggag  cctgtgcat  taatgaaac  gacaactcc  1920
gcaaggtgt  ctgcaggga  ctttccggc  gctgtgtgc  ctatgtcga  gctgaacaa  1980
agaacttat  tttgaggaa  ggaaagccc  gtacagtag  attttgtga  atgaatggc  2040
aatgtgaga  acgagtaca  gatgtaatt  aacgatttt  ggatttcat  gaccagctg  2100
gcatcaata  ttttggaaa  tttttagca  acaacatcg  tgggtctgt  ctggttttc  2160
ccttgatat  ttggattcc  ttcagcatt  ttgtccatt  tgtgtaacg  cgaaatgct  2220
agcagcatg  attctgcat  ggttcgcat  atcaaaccc  ttcctgcgc  ccagactcc  2280
ggccgcctg  agcctgccc  tgtgatccc  tcggcgcca  cagctccaa  actggacca  2340
cagagaatg  acaccatcc  ggaagaccc  agcacagac  cacatatgg  cgaggatgg  2400
tttgagaag  accccttcc  aaatagcag  acagctgcc  agtcatttg  ggatctcac  2460
gaccatccg  tcaccagaa  tgaaaaggc  gcctccttt  aactgcagc  tcagaatcg  2520
gttgacagc  aagaaacag  gtgctaatt  agttctcag  tcttctgac  taagtgtgc  2580
aaatatttt  atagatttg  cctacaatc  atcacagct  atattttgt  aagactggg  2640
agtgactta  cagatgctg  tcatgtgtt  gaacttcct  caggtaaac  gttcttgtg  2700
ggtttggcc  ttctccttt  gaaaaggta  ggtgaaggt  aatctagct  attttgagg  2760
tttcaggtt  tagttttta  aatatcttt  gacctgtgg  gcaaaagca  aaaatacag  2820
tggattggg  tatgagtat  tacgttttt  taaattaat  ttttatatt  ataacag  2877



<210> 1455
<211> 824
<212> PRT
<213> Homo sapiens
<308> P78536
<400> 1455

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
     50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
         195                200                205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
             580                585                590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
         595                600                605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
             740                745                750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
         755                760                765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
     770                775                780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
 785                790                795                800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                 805                810                815
Val Asp Ser Lys Glu Thr Glu Cys 
             820



<210> 1456
<211> 4128
<212> DNA
<213> Rattus norvegicus
<308> AJ012603
<400> 1456

ggttccggc  gtgggcagc  gggtggtcc  cgactgcgg  cggaagcag  ctgagcggc  60
ctcggcgag  gccgcctgt  cttccgggg  cttcagcct  gctcttgag  tttccctgt  120
ggcggcgcg  gagggaaaa  tttgcaggg  cgtgctggg  agatcacct  cgcttccca  180
tgtgagcag  ttctcgaac  ctctctcta  aaggttgcc  agagaggtg  tggacggga  240
catgaggca  cgtctcctc  tcctgacca  tttggtgcc  ttcgtcctg  caccccgac  300
tccggagga  ccaggctct  gctcccacc  gcgacttga  aagcttgat  ctttgctct  360
agactacga  atcctctct  tatctaata  ccagcagca  tccataagg  aaagggatc  420
acagtctgc  acacactta  aaacactac  aactttttc  gctttgaaa  ggcatttta  480
attatactt  acatcaagt  cagaacgct  ttcacagaa  ttgcgagtc  tggtggtgg  540
tgggaaaga  gaaagcgag  acagtgtga  gtggcagga  ttcttcagc  gacatgtgg  600
tggtgagcc  gactctagg  ttctagcgc  cataggaga  gatgatgtc  cagtaagaa  660
caacacaga  ggggcagaa  ataacatag  gccactttg  aggtttgtt  atgatacta  720
agataaaag  atgctggtg  ataagtctg  agatatcaa  gatttttca  gtttgcagt  780
tccaaaagt  tgtggttat  taaatgcag  tagtgaaga  ttgcttcca  aagggctca  840
agacagaga  ccatctgaa  agtttgtcc  tcgagtgaa  aggcgagct  aacctaacc  900
attgaagaa  acttgtaaa  tactggtgg  ggcagatca  cgattttat  agtacatgg  960
ccgaggaga  gagagcact  ctacaaatt  cttaataga  ttaattgac  gagttgatg  1020
catataccg  aacacctcg  gggacaatg  aggatttaa  ggttatgga  tacagatag  1080
acagattcg  attctcaag  ctccacaag  ggtaaaacc  ggtgaaaga  acttcaata  1140
ggcaaaaag  tttccaaat  aagaaaagg  tgcttggga  gtgaagatg  tgctggagc  1200
atttagcct  gatatagct  aagaggcct  taaagtctg  ctggctcat  ttttcacct  1260
ccaagattt  gatatggga  ctcttggat  agcttacgt  ggttctccc  gagcaaaca  1320
tcatggagg  gtttgtcca  aagcttatt  caacccagg  gtgaagaag  acatctatt  1380
gaatagtgg  ctgacaagt  caaaaaatt  tggtaaaac  atccttaca  aggaggctg  1440
cctggttac  actcatgaa  tgggacaca  ttttggagc  gaacatgat  ctgatgggc  1500
ggcagagtg  gccccaaat  aggaccaag  aggaaagta  gttatgtac  ccatagctg  1560
gagtggtga  catgagaat  ataagatgt  ttcaaactg  agtaaacag  ccatctaca  1620
gaccataga  agcaaggct  aagagtgct  ccaggagcg  agcaacaag  tgtgcggca  1680
ctccagggt  gacgaagga  aagagtgtg  cccgggcat  atgtacctg  acaacgaca  1740
ctgctgcaa  agtgactgc  cactgaagc  aggtgtgca  tgcagtgat  ggaatagtc  1800
ttgctgtaa  aattgtcag  ttgagacgg  ccagaagaa  tgccaggag  ctatcaatg  1860
tacttgcaa  ggagtgtct  actgcacag  gaatagcag  gagtgcccc  caccaggag  1920
tgctgaaga  gacactgtg  gcttggacc  gggcaagtg  aaggctggg  aatgcatcc  1980
tttctgcaa  agggagcag  agctggagt  ctgcgcatg  gctgacacc  acaactcgt  2040
caaggtatg  tgcaggaac  tttctggcc  atgtgtgcc  tacgtcgat  cagagcaaa  2100
gaacttatt  ttgaggaaa  ggaagccct  tacagtagg  ttttgtgac  tgaatggca  2160
atgtgagaa  cgggtacag  acgtaattg  gcggttttg  gatttcatt  accagctga  2220
catcaacac  tttgggaag  ttctggcag  caacatcgt  gggtctgtt  tggttttct  2280
cttgatatt  tggattcct  tcagcattc  tgtccactg  gtggataag  aactggaca  2340
gcagtatga  tccctgtct  tgtttcatc  cagtaacat  gagatgttg  gcagcatgg  2400
ctcagcatc  gttcgcatt  tcaagccgt  ccctgcacc  cagactcca  gtcgtctgc  2460
ggccctgca  ccggctgca  tgatgccgc  agtgtctgc  gctccaaaa  tggatcacc  2520
gaggatgga  accatccag  aagacccca  cacagattc  catgtggat  atgatggct  2580
tgagaagga  cccttcccc  acagcagtg  agccgccaa  tcctttgag  acctcacag  2640
ccacccagt  accaggagt  agaaggccg  ctccttcaa  ctgcagcgt  agagccgag  2700
tgatagcaa  gagacagag  gttagtggg  gcctgggcc  gctctgggg  acacagacc  2760
acagatgtt  cacagagct  acctgaatc  aaatagact  taatgatct  agaaacggg  2820
gcagcttag  agatgctgg  catgtgaca  gaccttcac  tgacatcct  tgtatgtag  2880
ccctttgaa  aggtgaggt  aatctggct  atttaaggc  ttcaggttt  ggggttttc  2940
tttgtaatc  aaaaatctc  tttgacctg  ggtgcagaa  cagaaaata  ggctggatc  3000
agttcctgg  gacagcact  attaagcct  cagtctgtt  ttctgtatg  tgtaaggtc  3060
tctcactac  gtgaagcac  tagcagtga  gataactgg  acacagact  tttgggggt  3120
ttggccttc  catgtgcgt  gtctccaaa  gccgtctgt  ttggcactg  actttgtgg  3180
tacagtcct  tccaagatg  agactagct  tggaacagt  tatacaaac  gccacatga  3240
cttcaagat  gcctattaa  tgcttagcc  caggttccc  ggacagttt  tccgttttg  3300
aaaaagtgt  ttcacgggt  tctaaacat  gtttgtctt  aaaaatact  ggctggaga  3360
ttggcccca  agttaagag  acttggttt  attcccagt  cccacacgg  ggctcttaa  3420
tccaatccc  ggggagatg  catcttctg  actctagaa  acaaggcat  cattggtgc  3480
gtcaaacat  caggcaaca  acacaaatt  agaaagcca  gtgctgtaa  aagttgcac  3540
tcccccaac  tacagtgct  cgcggtctg  gctggagtg  agctctctc  tgaacactc  3600
ggaaggctg  caggtgctg  gctggctag  gagacgggt  gggcccagc  ctggaagaa  3660
cgtcttcag  ctcagcaag  agacactcg  gttacctca  gctttgggg  ttcaggacc  3720
aggatgttt  gtacttatt  tgtgaggat  aataccatt  gcctgaatt  tcatttctg  3780
aagttttag  tataaaagc  ttttttctt  taagaattg  aatgtgctc  ccagcaaac  3840
cgtcttaac  agaataact  gtaactctg  ggacagtta  ccaaacctg  gccttgtct  3900
tcctgaggg  gtctgttac  ctaatactt  aacatgtac  ttgtggtat  ggctccttt  3960
actagtcat  acagcctta  atgttagtt  cactttgag  atttgctct  aggtgagtg  4020
ggtgtgtgg  tgtatgtat  aatgaaaca  ttggcagaa  ataagaaaa  catttttat  4080
aaattgtga  tttttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4128



<210> 1457
<211> 827
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1K9
<400> 1457

Met Arg Gln Arg Leu Leu Phe Leu Thr Thr Leu Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Glu Glu Pro Gly Ser Gly Ser His Leu Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Ile Arg Lys Arg Asp Leu Gln Ser Ala Thr 
     50                  55                  60
His Leu Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Leu Arg Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Glu Glu Ser Glu Tyr Ser Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Ser Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Gly Asp Asp Asp Val Thr Val Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asp Phe Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Asn Ala Asp Ser Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Ile Asp Arg Glu Pro Ser Glu Glu Phe 
         195                200                205
Val Arg Arg Val Lys Arg Arg Ala Glu Pro Asn Pro Leu Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Lys Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Val Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Arg His Phe Asn Met Ala Lys Ser Phe 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Leu Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Asn Pro Gly Val Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Pro Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asp 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Ala Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Lys Arg Glu Gln Glu Leu Glu Ser Cys Ala 
             580                585                590
Cys Ala Asp Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asn Leu Ser 
         595                600                605
Gly Pro Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His His Ser Asn Ile Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Ala Leu Gln Pro Ala Ala Met Met Pro Pro Val Ser 
             740                745                750
Ala Ala Pro Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp 
         755                760                765
Pro Ser Thr Asp Ser His Val Asp Asp Asp Gly Phe Glu Lys Asp Pro 
     770                775                780
Phe Pro Asn Ser Ser Ala Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp 
 785                790                795                800
His Pro Val Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg 
                 805                810                815
Gln Ser Arg Val Asp Ser Lys Glu Thr Glu Cys 
             820                825



<210> 1458
<211> 2877
<212> DNA
<213> Homo sapiens
<308> U69612
<400> 1458

ggaaaagag  attgagggg  taggccggg  ggatcccgt  ctcccccga  gtgagcagt  60
ttccgaaac  ccgtcaggc  aaggctgcc  agagaggtg  agtcggtag  ggggccggg  120
acatgaggc  gtctctcct  ttcctgacc  gcgtggttc  tttcgtgct  gcgccgcga  180
ctccggatg  cccgggctt  ggcccccac  agagactcg  gaagcttga  tctttgctc  240
cagactacg  tattctctc  ttatctaat  tccagcagc  ttcggtaag  aaaagagat  300
tacagactt  aacacatgt  gaaacacta  taacttttt  agctttgaa  aggcatttt  360
aattatacc  gacatcaag  actgaacgt  tttcacaaa  tttcaaggt  gtggtggtg  420
atggtaaaa  cgaaagcga  tacactgta  aatggcagg  cttcttcac  ggacacgtg  480
ttggtgagc  tgactctag  gttctagcc  acataagag  tgatgatgt  ataatcaga  540
tcaacacag  tggggccga  tataacata  agccacttt  gagatttgt  aatgatacc  600
aagacaaaa  aatgttagt  tataaatct  aagatatca  gaatgtttc  cgtttgcag  660
ctccaaaag  gtgtggtta  ttaaaagtg  ataatgaag  gttgctccc  aaagggtta  720
tagacagag  accacctga  gagcttgtt  atcgagtga  aagaagagc  gacccagat  780
ccatgaaga  cacgtgtaa  ttattggtg  tagcagatc  tcgcttcta  agatacatg  840
gcagagggg  agagagtac  actacaaat  acttaatag  gctaattga  agagttgat  900
acatctatc  gaacacttc  tgggataat  caggtttta  aggctatgg  atacagata  960
agcagattc  cattctcaa  tctccacaa  aggtaaaac  tggtgaaaa  cactacaac  1020
tggcaaaaa  ttacccaaa  gaagaaaag  atgcttggg  tgtgaagat  ttgctagag  1080
aatttagct  tgatatagc  gaggaagca  ctaaagttt  cttggcaca  cttttcaca  1140
accaagatt  tgatatggg  actcttgga  tagcttatg  tggctctcc  agagcaaac  1200
gccatggag  tgtttgtcc  aaggcttat  atagcccag  tgggaagaa  aatatctat  1260
tgaatagtg  tttgacgag  acaaagaat  atggtaaaa  catccttac  aaggaagct  1320
acctggtta  aactcatga  ttgggacat  attttggag  agaacatga  ccggatggt  1380
tagcagaat  tgccccgaa  gaggaccag  gagggaaat  tgtcatgta  cccatagct  1440
tgagtggcg  tcacgagaa  aataagatg  tttcaaact  cagtaaaca  tcaatctat  1500
agaccattg  aagtaaggc  caggagtgt  ttcaagaac  cagcaataa  gtttgtggg  1560
actcgaggg  ggatgaagg  gaagagtgt  atcctggca  catgtatct  aacaacgac  1620
cctgctgca  cagcgactg  acgttgaag  aaggtgtcc  gtgcagtga  aggaacagt  1680
cttgctgta  aaactgtca  tttgagact  cccagaaga  gtgccagga  gcgattaat  1740
ctacttgca  aggcgtgtc  tactgcaca  gtaatagca  tgagtgccc  cctccagga  1800
atgctgaag  tgacactgt  tgcttggat  ttggcaagt  taaggatgg  aaatgcatc  1860
ctttctgcg  gagggaaca  cagctggag  cctgtgcat  taatgaaac  gacaactcc  1920
gcaaggtgt  ctgcaggga  ctttccggc  gctgtgtgc  ctatgtcga  gctgaacaa  1980
agaacttat  tttgaggaa  ggaaagccc  gtacagtag  attttgtga  atgaatggc  2040
aatgtgaga  acgagtaca  gatgtaatt  aacgatttt  ggatttcat  gaccagctg  2100
gcatcaata  ttttggaaa  tttttagca  acaacatcg  tgggtctgt  ctggttttc  2160
ccttgatat  ttggattcc  ttcagcatt  ttgtccatt  tgtgtaacg  cgaaatgct  2220
agcagcatg  attctgcat  ggttcgcat  atcaaaccc  ttcctgcgc  ccagactcc  2280
ggccgcctg  agcctgccc  tgtgatccc  tcggcgcca  cagctccaa  actggacca  2340
cagagaatg  acaccatcc  ggaagaccc  agcacagac  cacatatgg  cgaggatgg  2400
tttgagaag  accccttcc  aaatagcag  acagctgcc  agtcatttg  ggatctcac  2460
gaccatccg  tcaccagaa  tgaaaaggc  gcctccttt  aactgcagc  tcagaatcg  2520
gttgacagc  aagaaacag  gtgctaatt  agttctcag  tcttctgac  taagtgtgc  2580
aaatatttt  atagatttg  cctacaatc  atcacagct  atattttgt  aagactggg  2640
agtgactta  cagatgctg  tcatgtgtt  gaacttcct  caggtaaac  gttcttgtg  2700
ggtttggcc  ttctccttt  gaaaaggta  ggtgaaggt  aatctagct  attttgagg  2760
tttcaggtt  tagttttta  aatatcttt  gacctgtgg  gcaaaagca  aaaatacag  2820
tggattggg  tatgagtat  tacgttttt  taaattaat  ttttatatt  ataacag  2877



<210> 1459
<211> 824
<212> PRT
<213> Homo sapiens
<308> P78536
<400> 1459

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
     50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
         195                200                205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
             580                585                590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
         595                600                605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
             740                745                750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
         755                760                765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
     770                775                780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
 785                790                795                800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                 805                810                815
Val Asp Ser Lys Glu Thr Glu Cys 
             820



<210> 1460
<211> 4128
<212> DNA
<213> Rattus norvegicus
<308> AJ012603
<400> 1460

ggttccggc  gtgggcagc  gggtggtcc  cgactgcgg  cggaagcag  ctgagcggc  60
ctcggcgag  gccgcctgt  cttccgggg  cttcagcct  gctcttgag  tttccctgt  120
ggcggcgcg  gagggaaaa  tttgcaggg  cgtgctggg  agatcacct  cgcttccca  180
tgtgagcag  ttctcgaac  ctctctcta  aaggttgcc  agagaggtg  tggacggga  240
catgaggca  cgtctcctc  tcctgacca  tttggtgcc  ttcgtcctg  caccccgac  300
tccggagga  ccaggctct  gctcccacc  gcgacttga  aagcttgat  ctttgctct  360
agactacga  atcctctct  tatctaata  ccagcagca  tccataagg  aaagggatc  420
acagtctgc  acacactta  aaacactac  aactttttc  gctttgaaa  ggcatttta  480
attatactt  acatcaagt  cagaacgct  ttcacagaa  ttgcgagtc  tggtggtgg  540
tgggaaaga  gaaagcgag  acagtgtga  gtggcagga  ttcttcagc  gacatgtgg  600
tggtgagcc  gactctagg  ttctagcgc  cataggaga  gatgatgtc  cagtaagaa  660
caacacaga  ggggcagaa  ataacatag  gccactttg  aggtttgtt  atgatacta  720
agataaaag  atgctggtg  ataagtctg  agatatcaa  gatttttca  gtttgcagt  780
tccaaaagt  tgtggttat  taaatgcag  tagtgaaga  ttgcttcca  aagggctca  840
agacagaga  ccatctgaa  agtttgtcc  tcgagtgaa  aggcgagct  aacctaacc  900
attgaagaa  acttgtaaa  tactggtgg  ggcagatca  cgattttat  agtacatgg  960
ccgaggaga  gagagcact  ctacaaatt  cttaataga  ttaattgac  gagttgatg  1020
catataccg  aacacctcg  gggacaatg  aggatttaa  ggttatgga  tacagatag  1080
acagattcg  attctcaag  ctccacaag  ggtaaaacc  ggtgaaaga  acttcaata  1140
ggcaaaaag  tttccaaat  aagaaaagg  tgcttggga  gtgaagatg  tgctggagc  1200
atttagcct  gatatagct  aagaggcct  taaagtctg  ctggctcat  ttttcacct  1260
ccaagattt  gatatggga  ctcttggat  agcttacgt  ggttctccc  gagcaaaca  1320
tcatggagg  gtttgtcca  aagcttatt  caacccagg  gtgaagaag  acatctatt  1380
gaatagtgg  ctgacaagt  caaaaaatt  tggtaaaac  atccttaca  aggaggctg  1440
cctggttac  actcatgaa  tgggacaca  ttttggagc  gaacatgat  ctgatgggc  1500
ggcagagtg  gccccaaat  aggaccaag  aggaaagta  gttatgtac  ccatagctg  1560
gagtggtga  catgagaat  ataagatgt  ttcaaactg  agtaaacag  ccatctaca  1620
gaccataga  agcaaggct  aagagtgct  ccaggagcg  agcaacaag  tgtgcggca  1680
ctccagggt  gacgaagga  aagagtgtg  cccgggcat  atgtacctg  acaacgaca  1740
ctgctgcaa  agtgactgc  cactgaagc  aggtgtgca  tgcagtgat  ggaatagtc  1800
ttgctgtaa  aattgtcag  ttgagacgg  ccagaagaa  tgccaggag  ctatcaatg  1860
tacttgcaa  ggagtgtct  actgcacag  gaatagcag  gagtgcccc  caccaggag  1920
tgctgaaga  gacactgtg  gcttggacc  gggcaagtg  aaggctggg  aatgcatcc  1980
tttctgcaa  agggagcag  agctggagt  ctgcgcatg  gctgacacc  acaactcgt  2040
caaggtatg  tgcaggaac  tttctggcc  atgtgtgcc  tacgtcgat  cagagcaaa  2100
gaacttatt  ttgaggaaa  ggaagccct  tacagtagg  ttttgtgac  tgaatggca  2160
atgtgagaa  cgggtacag  acgtaattg  gcggttttg  gatttcatt  accagctga  2220
catcaacac  tttgggaag  ttctggcag  caacatcgt  gggtctgtt  tggttttct  2280
cttgatatt  tggattcct  tcagcattc  tgtccactg  gtggataag  aactggaca  2340
gcagtatga  tccctgtct  tgtttcatc  cagtaacat  gagatgttg  gcagcatgg  2400
ctcagcatc  gttcgcatt  tcaagccgt  ccctgcacc  cagactcca  gtcgtctgc  2460
ggccctgca  ccggctgca  tgatgccgc  agtgtctgc  gctccaaaa  tggatcacc  2520
gaggatgga  accatccag  aagacccca  cacagattc  catgtggat  atgatggct  2580
tgagaagga  cccttcccc  acagcagtg  agccgccaa  tcctttgag  acctcacag  2640
ccacccagt  accaggagt  agaaggccg  ctccttcaa  ctgcagcgt  agagccgag  2700
tgatagcaa  gagacagag  gttagtggg  gcctgggcc  gctctgggg  acacagacc  2760
acagatgtt  cacagagct  acctgaatc  aaatagact  taatgatct  agaaacggg  2820
gcagcttag  agatgctgg  catgtgaca  gaccttcac  tgacatcct  tgtatgtag  2880
ccctttgaa  aggtgaggt  aatctggct  atttaaggc  ttcaggttt  ggggttttc  2940
tttgtaatc  aaaaatctc  tttgacctg  ggtgcagaa  cagaaaata  ggctggatc  3000
agttcctgg  gacagcact  attaagcct  cagtctgtt  ttctgtatg  tgtaaggtc  3060
tctcactac  gtgaagcac  tagcagtga  gataactgg  acacagact  tttgggggt  3120
ttggccttc  catgtgcgt  gtctccaaa  gccgtctgt  ttggcactg  actttgtgg  3180
tacagtcct  tccaagatg  agactagct  tggaacagt  tatacaaac  gccacatga  3240
cttcaagat  gcctattaa  tgcttagcc  caggttccc  ggacagttt  tccgttttg  3300
aaaaagtgt  ttcacgggt  tctaaacat  gtttgtctt  aaaaatact  ggctggaga  3360
ttggcccca  agttaagag  acttggttt  attcccagt  cccacacgg  ggctcttaa  3420
tccaatccc  ggggagatg  catcttctg  actctagaa  acaaggcat  cattggtgc  3480
gtcaaacat  caggcaaca  acacaaatt  agaaagcca  gtgctgtaa  aagttgcac  3540
tcccccaac  tacagtgct  cgcggtctg  gctggagtg  agctctctc  tgaacactc  3600
ggaaggctg  caggtgctg  gctggctag  gagacgggt  gggcccagc  ctggaagaa  3660
cgtcttcag  ctcagcaag  agacactcg  gttacctca  gctttgggg  ttcaggacc  3720
aggatgttt  gtacttatt  tgtgaggat  aataccatt  gcctgaatt  tcatttctg  3780
aagttttag  tataaaagc  ttttttctt  taagaattg  aatgtgctc  ccagcaaac  3840
cgtcttaac  agaataact  gtaactctg  ggacagtta  ccaaacctg  gccttgtct  3900
tcctgaggg  gtctgttac  ctaatactt  aacatgtac  ttgtggtat  ggctccttt  3960
actagtcat  acagcctta  atgttagtt  cactttgag  atttgctct  aggtgagtg  4020
ggtgtgtgg  tgtatgtat  aatgaaaca  ttggcagaa  ataagaaaa  catttttat  4080
aaattgtga  tttttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4128



<210> 1461
<211> 827
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1K9
<400> 1461

Met Arg Gln Arg Leu Leu Phe Leu Thr Thr Leu Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Glu Glu Pro Gly Ser Gly Ser His Leu Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Ile Arg Lys Arg Asp Leu Gln Ser Ala Thr 
     50                  55                  60
His Leu Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Leu Arg Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Glu Glu Ser Glu Tyr Ser Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Ser Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Gly Asp Asp Asp Val Thr Val Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asp Phe Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Asn Ala Asp Ser Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Ile Asp Arg Glu Pro Ser Glu Glu Phe 
         195                200                205
Val Arg Arg Val Lys Arg Arg Ala Glu Pro Asn Pro Leu Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Lys Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Val Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Arg His Phe Asn Met Ala Lys Ser Phe 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Leu Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Asn Pro Gly Val Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Pro Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asp 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Ala Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Lys Arg Glu Gln Glu Leu Glu Ser Cys Ala 
             580                585                590
Cys Ala Asp Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asn Leu Ser 
         595                600                605
Gly Pro Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His His Ser Asn Ile Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Ala Leu Gln Pro Ala Ala Met Met Pro Pro Val Ser 
             740                745                750
Ala Ala Pro Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp 
         755                760                765
Pro Ser Thr Asp Ser His Val Asp Asp Asp Gly Phe Glu Lys Asp Pro 
     770                775                780
Phe Pro Asn Ser Ser Ala Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp 
 785                790                795                800
His Pro Val Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg 
                 805                810                815
Gln Ser Arg Val Asp Ser Lys Glu Thr Glu Cys 
             820                825



<210> 1462
<211> 2877
<212> DNA
<213> Homo sapiens
<308> U69612
<400> 1462

ggaaaagag  attgagggg  taggccggg  ggatcccgt  ctcccccga  gtgagcagt  60
ttccgaaac  ccgtcaggc  aaggctgcc  agagaggtg  agtcggtag  ggggccggg  120
acatgaggc  gtctctcct  ttcctgacc  gcgtggttc  tttcgtgct  gcgccgcga  180
ctccggatg  cccgggctt  ggcccccac  agagactcg  gaagcttga  tctttgctc  240
cagactacg  tattctctc  ttatctaat  tccagcagc  ttcggtaag  aaaagagat  300
tacagactt  aacacatgt  gaaacacta  taacttttt  agctttgaa  aggcatttt  360
aattatacc  gacatcaag  actgaacgt  tttcacaaa  tttcaaggt  gtggtggtg  420
atggtaaaa  cgaaagcga  tacactgta  aatggcagg  cttcttcac  ggacacgtg  480
ttggtgagc  tgactctag  gttctagcc  acataagag  tgatgatgt  ataatcaga  540
tcaacacag  tggggccga  tataacata  agccacttt  gagatttgt  aatgatacc  600
aagacaaaa  aatgttagt  tataaatct  aagatatca  gaatgtttc  cgtttgcag  660
ctccaaaag  gtgtggtta  ttaaaagtg  ataatgaag  gttgctccc  aaagggtta  720
tagacagag  accacctga  gagcttgtt  atcgagtga  aagaagagc  gacccagat  780
ccatgaaga  cacgtgtaa  ttattggtg  tagcagatc  tcgcttcta  agatacatg  840
gcagagggg  agagagtac  actacaaat  acttaatag  gctaattga  agagttgat  900
acatctatc  gaacacttc  tgggataat  caggtttta  aggctatgg  atacagata  960
agcagattc  cattctcaa  tctccacaa  aggtaaaac  tggtgaaaa  cactacaac  1020
tggcaaaaa  ttacccaaa  gaagaaaag  atgcttggg  tgtgaagat  ttgctagag  1080
aatttagct  tgatatagc  gaggaagca  ctaaagttt  cttggcaca  cttttcaca  1140
accaagatt  tgatatggg  actcttgga  tagcttatg  tggctctcc  agagcaaac  1200
gccatggag  tgtttgtcc  aaggcttat  atagcccag  tgggaagaa  aatatctat  1260
tgaatagtg  tttgacgag  acaaagaat  atggtaaaa  catccttac  aaggaagct  1320
acctggtta  aactcatga  ttgggacat  attttggag  agaacatga  ccggatggt  1380
tagcagaat  tgccccgaa  gaggaccag  gagggaaat  tgtcatgta  cccatagct  1440
tgagtggcg  tcacgagaa  aataagatg  tttcaaact  cagtaaaca  tcaatctat  1500
agaccattg  aagtaaggc  caggagtgt  ttcaagaac  cagcaataa  gtttgtggg  1560
actcgaggg  ggatgaagg  gaagagtgt  atcctggca  catgtatct  aacaacgac  1620
cctgctgca  cagcgactg  acgttgaag  aaggtgtcc  gtgcagtga  aggaacagt  1680
cttgctgta  aaactgtca  tttgagact  cccagaaga  gtgccagga  gcgattaat  1740
ctacttgca  aggcgtgtc  tactgcaca  gtaatagca  tgagtgccc  cctccagga  1800
atgctgaag  tgacactgt  tgcttggat  ttggcaagt  taaggatgg  aaatgcatc  1860
ctttctgcg  gagggaaca  cagctggag  cctgtgcat  taatgaaac  gacaactcc  1920
gcaaggtgt  ctgcaggga  ctttccggc  gctgtgtgc  ctatgtcga  gctgaacaa  1980
agaacttat  tttgaggaa  ggaaagccc  gtacagtag  attttgtga  atgaatggc  2040
aatgtgaga  acgagtaca  gatgtaatt  aacgatttt  ggatttcat  gaccagctg  2100
gcatcaata  ttttggaaa  tttttagca  acaacatcg  tgggtctgt  ctggttttc  2160
ccttgatat  ttggattcc  ttcagcatt  ttgtccatt  tgtgtaacg  cgaaatgct  2220
agcagcatg  attctgcat  ggttcgcat  atcaaaccc  ttcctgcgc  ccagactcc  2280
ggccgcctg  agcctgccc  tgtgatccc  tcggcgcca  cagctccaa  actggacca  2340
cagagaatg  acaccatcc  ggaagaccc  agcacagac  cacatatgg  cgaggatgg  2400
tttgagaag  accccttcc  aaatagcag  acagctgcc  agtcatttg  ggatctcac  2460
gaccatccg  tcaccagaa  tgaaaaggc  gcctccttt  aactgcagc  tcagaatcg  2520
gttgacagc  aagaaacag  gtgctaatt  agttctcag  tcttctgac  taagtgtgc  2580
aaatatttt  atagatttg  cctacaatc  atcacagct  atattttgt  aagactggg  2640
agtgactta  cagatgctg  tcatgtgtt  gaacttcct  caggtaaac  gttcttgtg  2700
ggtttggcc  ttctccttt  gaaaaggta  ggtgaaggt  aatctagct  attttgagg  2760
tttcaggtt  tagttttta  aatatcttt  gacctgtgg  gcaaaagca  aaaatacag  2820
tggattggg  tatgagtat  tacgttttt  taaattaat  ttttatatt  ataacag  2877



<210> 1463
<211> 824
<212> PRT
<213> Homo sapiens
<308> P78536
<400> 1463

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
     50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
         195                200                205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
             580                585                590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
         595                600                605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
             740                745                750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
         755                760                765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
     770                775                780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
 785                790                795                800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                 805                810                815
Val Asp Ser Lys Glu Thr Glu Cys 
             820



<210> 1464
<211> 4128
<212> DNA
<213> Rattus norvegicus
<308> AJ012603
<400> 1464

ggttccggc  gtgggcagc  gggtggtcc  cgactgcgg  cggaagcag  ctgagcggc  60
ctcggcgag  gccgcctgt  cttccgggg  cttcagcct  gctcttgag  tttccctgt  120
ggcggcgcg  gagggaaaa  tttgcaggg  cgtgctggg  agatcacct  cgcttccca  180
tgtgagcag  ttctcgaac  ctctctcta  aaggttgcc  agagaggtg  tggacggga  240
catgaggca  cgtctcctc  tcctgacca  tttggtgcc  ttcgtcctg  caccccgac  300
tccggagga  ccaggctct  gctcccacc  gcgacttga  aagcttgat  ctttgctct  360
agactacga  atcctctct  tatctaata  ccagcagca  tccataagg  aaagggatc  420
acagtctgc  acacactta  aaacactac  aactttttc  gctttgaaa  ggcatttta  480
attatactt  acatcaagt  cagaacgct  ttcacagaa  ttgcgagtc  tggtggtgg  540
tgggaaaga  gaaagcgag  acagtgtga  gtggcagga  ttcttcagc  gacatgtgg  600
tggtgagcc  gactctagg  ttctagcgc  cataggaga  gatgatgtc  cagtaagaa  660
caacacaga  ggggcagaa  ataacatag  gccactttg  aggtttgtt  atgatacta  720
agataaaag  atgctggtg  ataagtctg  agatatcaa  gatttttca  gtttgcagt  780
tccaaaagt  tgtggttat  taaatgcag  tagtgaaga  ttgcttcca  aagggctca  840
agacagaga  ccatctgaa  agtttgtcc  tcgagtgaa  aggcgagct  aacctaacc  900
attgaagaa  acttgtaaa  tactggtgg  ggcagatca  cgattttat  agtacatgg  960
ccgaggaga  gagagcact  ctacaaatt  cttaataga  ttaattgac  gagttgatg  1020
catataccg  aacacctcg  gggacaatg  aggatttaa  ggttatgga  tacagatag  1080
acagattcg  attctcaag  ctccacaag  ggtaaaacc  ggtgaaaga  acttcaata  1140
ggcaaaaag  tttccaaat  aagaaaagg  tgcttggga  gtgaagatg  tgctggagc  1200
atttagcct  gatatagct  aagaggcct  taaagtctg  ctggctcat  ttttcacct  1260
ccaagattt  gatatggga  ctcttggat  agcttacgt  ggttctccc  gagcaaaca  1320
tcatggagg  gtttgtcca  aagcttatt  caacccagg  gtgaagaag  acatctatt  1380
gaatagtgg  ctgacaagt  caaaaaatt  tggtaaaac  atccttaca  aggaggctg  1440
cctggttac  actcatgaa  tgggacaca  ttttggagc  gaacatgat  ctgatgggc  1500
ggcagagtg  gccccaaat  aggaccaag  aggaaagta  gttatgtac  ccatagctg  1560
gagtggtga  catgagaat  ataagatgt  ttcaaactg  agtaaacag  ccatctaca  1620
gaccataga  agcaaggct  aagagtgct  ccaggagcg  agcaacaag  tgtgcggca  1680
ctccagggt  gacgaagga  aagagtgtg  cccgggcat  atgtacctg  acaacgaca  1740
ctgctgcaa  agtgactgc  cactgaagc  aggtgtgca  tgcagtgat  ggaatagtc  1800
ttgctgtaa  aattgtcag  ttgagacgg  ccagaagaa  tgccaggag  ctatcaatg  1860
tacttgcaa  ggagtgtct  actgcacag  gaatagcag  gagtgcccc  caccaggag  1920
tgctgaaga  gacactgtg  gcttggacc  gggcaagtg  aaggctggg  aatgcatcc  1980
tttctgcaa  agggagcag  agctggagt  ctgcgcatg  gctgacacc  acaactcgt  2040
caaggtatg  tgcaggaac  tttctggcc  atgtgtgcc  tacgtcgat  cagagcaaa  2100
gaacttatt  ttgaggaaa  ggaagccct  tacagtagg  ttttgtgac  tgaatggca  2160
atgtgagaa  cgggtacag  acgtaattg  gcggttttg  gatttcatt  accagctga  2220
catcaacac  tttgggaag  ttctggcag  caacatcgt  gggtctgtt  tggttttct  2280
cttgatatt  tggattcct  tcagcattc  tgtccactg  gtggataag  aactggaca  2340
gcagtatga  tccctgtct  tgtttcatc  cagtaacat  gagatgttg  gcagcatgg  2400
ctcagcatc  gttcgcatt  tcaagccgt  ccctgcacc  cagactcca  gtcgtctgc  2460
ggccctgca  ccggctgca  tgatgccgc  agtgtctgc  gctccaaaa  tggatcacc  2520
gaggatgga  accatccag  aagacccca  cacagattc  catgtggat  atgatggct  2580
tgagaagga  cccttcccc  acagcagtg  agccgccaa  tcctttgag  acctcacag  2640
ccacccagt  accaggagt  agaaggccg  ctccttcaa  ctgcagcgt  agagccgag  2700
tgatagcaa  gagacagag  gttagtggg  gcctgggcc  gctctgggg  acacagacc  2760
acagatgtt  cacagagct  acctgaatc  aaatagact  taatgatct  agaaacggg  2820
gcagcttag  agatgctgg  catgtgaca  gaccttcac  tgacatcct  tgtatgtag  2880
ccctttgaa  aggtgaggt  aatctggct  atttaaggc  ttcaggttt  ggggttttc  2940
tttgtaatc  aaaaatctc  tttgacctg  ggtgcagaa  cagaaaata  ggctggatc  3000
agttcctgg  gacagcact  attaagcct  cagtctgtt  ttctgtatg  tgtaaggtc  3060
tctcactac  gtgaagcac  tagcagtga  gataactgg  acacagact  tttgggggt  3120
ttggccttc  catgtgcgt  gtctccaaa  gccgtctgt  ttggcactg  actttgtgg  3180
tacagtcct  tccaagatg  agactagct  tggaacagt  tatacaaac  gccacatga  3240
cttcaagat  gcctattaa  tgcttagcc  caggttccc  ggacagttt  tccgttttg  3300
aaaaagtgt  ttcacgggt  tctaaacat  gtttgtctt  aaaaatact  ggctggaga  3360
ttggcccca  agttaagag  acttggttt  attcccagt  cccacacgg  ggctcttaa  3420
tccaatccc  ggggagatg  catcttctg  actctagaa  acaaggcat  cattggtgc  3480
gtcaaacat  caggcaaca  acacaaatt  agaaagcca  gtgctgtaa  aagttgcac  3540
tcccccaac  tacagtgct  cgcggtctg  gctggagtg  agctctctc  tgaacactc  3600
ggaaggctg  caggtgctg  gctggctag  gagacgggt  gggcccagc  ctggaagaa  3660
cgtcttcag  ctcagcaag  agacactcg  gttacctca  gctttgggg  ttcaggacc  3720
aggatgttt  gtacttatt  tgtgaggat  aataccatt  gcctgaatt  tcatttctg  3780
aagttttag  tataaaagc  ttttttctt  taagaattg  aatgtgctc  ccagcaaac  3840
cgtcttaac  agaataact  gtaactctg  ggacagtta  ccaaacctg  gccttgtct  3900
tcctgaggg  gtctgttac  ctaatactt  aacatgtac  ttgtggtat  ggctccttt  3960
actagtcat  acagcctta  atgttagtt  cactttgag  atttgctct  aggtgagtg  4020
ggtgtgtgg  tgtatgtat  aatgaaaca  ttggcagaa  ataagaaaa  catttttat  4080
aaattgtga  tttttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4128



<210> 1465
<211> 827
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1K9
<400> 1465

Met Arg Gln Arg Leu Leu Phe Leu Thr Thr Leu Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Glu Glu Pro Gly Ser Gly Ser His Leu Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Ile Arg Lys Arg Asp Leu Gln Ser Ala Thr 
     50                  55                  60
His Leu Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Leu Arg Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Glu Glu Ser Glu Tyr Ser Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Ser Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Gly Asp Asp Asp Val Thr Val Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asp Phe Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Asn Ala Asp Ser Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Ile Asp Arg Glu Pro Ser Glu Glu Phe 
         195                200                205
Val Arg Arg Val Lys Arg Arg Ala Glu Pro Asn Pro Leu Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Lys Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Val Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Arg His Phe Asn Met Ala Lys Ser Phe 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Leu Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Asn Pro Gly Val Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Pro Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asp 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Ala Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Lys Arg Glu Gln Glu Leu Glu Ser Cys Ala 
             580                585                590
Cys Ala Asp Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asn Leu Ser 
         595                600                605
Gly Pro Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His His Ser Asn Ile Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Ala Leu Gln Pro Ala Ala Met Met Pro Pro Val Ser 
             740                745                750
Ala Ala Pro Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp 
         755                760                765
Pro Ser Thr Asp Ser His Val Asp Asp Asp Gly Phe Glu Lys Asp Pro 
     770                775                780
Phe Pro Asn Ser Ser Ala Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp 
 785                790                795                800
His Pro Val Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg 
                 805                810                815
Gln Ser Arg Val Asp Ser Lys Glu Thr Glu Cys 
             820                825



<210> 1466
<211> 2877
<212> DNA
<213> Homo sapiens
<308> U69612
<400> 1466

ggaaaagag  attgagggg  taggccggg  ggatcccgt  ctcccccga  gtgagcagt  60
ttccgaaac  ccgtcaggc  aaggctgcc  agagaggtg  agtcggtag  ggggccggg  120
acatgaggc  gtctctcct  ttcctgacc  gcgtggttc  tttcgtgct  gcgccgcga  180
ctccggatg  cccgggctt  ggcccccac  agagactcg  gaagcttga  tctttgctc  240
cagactacg  tattctctc  ttatctaat  tccagcagc  ttcggtaag  aaaagagat  300
tacagactt  aacacatgt  gaaacacta  taacttttt  agctttgaa  aggcatttt  360
aattatacc  gacatcaag  actgaacgt  tttcacaaa  tttcaaggt  gtggtggtg  420
atggtaaaa  cgaaagcga  tacactgta  aatggcagg  cttcttcac  ggacacgtg  480
ttggtgagc  tgactctag  gttctagcc  acataagag  tgatgatgt  ataatcaga  540
tcaacacag  tggggccga  tataacata  agccacttt  gagatttgt  aatgatacc  600
aagacaaaa  aatgttagt  tataaatct  aagatatca  gaatgtttc  cgtttgcag  660
ctccaaaag  gtgtggtta  ttaaaagtg  ataatgaag  gttgctccc  aaagggtta  720
tagacagag  accacctga  gagcttgtt  atcgagtga  aagaagagc  gacccagat  780
ccatgaaga  cacgtgtaa  ttattggtg  tagcagatc  tcgcttcta  agatacatg  840
gcagagggg  agagagtac  actacaaat  acttaatag  gctaattga  agagttgat  900
acatctatc  gaacacttc  tgggataat  caggtttta  aggctatgg  atacagata  960
agcagattc  cattctcaa  tctccacaa  aggtaaaac  tggtgaaaa  cactacaac  1020
tggcaaaaa  ttacccaaa  gaagaaaag  atgcttggg  tgtgaagat  ttgctagag  1080
aatttagct  tgatatagc  gaggaagca  ctaaagttt  cttggcaca  cttttcaca  1140
accaagatt  tgatatggg  actcttgga  tagcttatg  tggctctcc  agagcaaac  1200
gccatggag  tgtttgtcc  aaggcttat  atagcccag  tgggaagaa  aatatctat  1260
tgaatagtg  tttgacgag  acaaagaat  atggtaaaa  catccttac  aaggaagct  1320
acctggtta  aactcatga  ttgggacat  attttggag  agaacatga  ccggatggt  1380
tagcagaat  tgccccgaa  gaggaccag  gagggaaat  tgtcatgta  cccatagct  1440
tgagtggcg  tcacgagaa  aataagatg  tttcaaact  cagtaaaca  tcaatctat  1500
agaccattg  aagtaaggc  caggagtgt  ttcaagaac  cagcaataa  gtttgtggg  1560
actcgaggg  ggatgaagg  gaagagtgt  atcctggca  catgtatct  aacaacgac  1620
cctgctgca  cagcgactg  acgttgaag  aaggtgtcc  gtgcagtga  aggaacagt  1680
cttgctgta  aaactgtca  tttgagact  cccagaaga  gtgccagga  gcgattaat  1740
ctacttgca  aggcgtgtc  tactgcaca  gtaatagca  tgagtgccc  cctccagga  1800
atgctgaag  tgacactgt  tgcttggat  ttggcaagt  taaggatgg  aaatgcatc  1860
ctttctgcg  gagggaaca  cagctggag  cctgtgcat  taatgaaac  gacaactcc  1920
gcaaggtgt  ctgcaggga  ctttccggc  gctgtgtgc  ctatgtcga  gctgaacaa  1980
agaacttat  tttgaggaa  ggaaagccc  gtacagtag  attttgtga  atgaatggc  2040
aatgtgaga  acgagtaca  gatgtaatt  aacgatttt  ggatttcat  gaccagctg  2100
gcatcaata  ttttggaaa  tttttagca  acaacatcg  tgggtctgt  ctggttttc  2160
ccttgatat  ttggattcc  ttcagcatt  ttgtccatt  tgtgtaacg  cgaaatgct  2220
agcagcatg  attctgcat  ggttcgcat  atcaaaccc  ttcctgcgc  ccagactcc  2280
ggccgcctg  agcctgccc  tgtgatccc  tcggcgcca  cagctccaa  actggacca  2340
cagagaatg  acaccatcc  ggaagaccc  agcacagac  cacatatgg  cgaggatgg  2400
tttgagaag  accccttcc  aaatagcag  acagctgcc  agtcatttg  ggatctcac  2460
gaccatccg  tcaccagaa  tgaaaaggc  gcctccttt  aactgcagc  tcagaatcg  2520
gttgacagc  aagaaacag  gtgctaatt  agttctcag  tcttctgac  taagtgtgc  2580
aaatatttt  atagatttg  cctacaatc  atcacagct  atattttgt  aagactggg  2640
agtgactta  cagatgctg  tcatgtgtt  gaacttcct  caggtaaac  gttcttgtg  2700
ggtttggcc  ttctccttt  gaaaaggta  ggtgaaggt  aatctagct  attttgagg  2760
tttcaggtt  tagttttta  aatatcttt  gacctgtgg  gcaaaagca  aaaatacag  2820
tggattggg  tatgagtat  tacgttttt  taaattaat  ttttatatt  ataacag  2877



<210> 1467
<211> 824
<212> PRT
<213> Homo sapiens
<308> P78536
<400> 1467

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
     50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
         195                200                205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
             580                585                590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
         595                600                605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
             740                745                750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
         755                760                765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
     770                775                780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
 785                790                795                800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                 805                810                815
Val Asp Ser Lys Glu Thr Glu Cys 
             820



<210> 1468
<211> 4128
<212> DNA
<213> Rattus norvegicus
<308> AJ012603
<400> 1468

ggttccggc  gtgggcagc  gggtggtcc  cgactgcgg  cggaagcag  ctgagcggc  60
ctcggcgag  gccgcctgt  cttccgggg  cttcagcct  gctcttgag  tttccctgt  120
ggcggcgcg  gagggaaaa  tttgcaggg  cgtgctggg  agatcacct  cgcttccca  180
tgtgagcag  ttctcgaac  ctctctcta  aaggttgcc  agagaggtg  tggacggga  240
catgaggca  cgtctcctc  tcctgacca  tttggtgcc  ttcgtcctg  caccccgac  300
tccggagga  ccaggctct  gctcccacc  gcgacttga  aagcttgat  ctttgctct  360
agactacga  atcctctct  tatctaata  ccagcagca  tccataagg  aaagggatc  420
acagtctgc  acacactta  aaacactac  aactttttc  gctttgaaa  ggcatttta  480
attatactt  acatcaagt  cagaacgct  ttcacagaa  ttgcgagtc  tggtggtgg  540
tgggaaaga  gaaagcgag  acagtgtga  gtggcagga  ttcttcagc  gacatgtgg  600
tggtgagcc  gactctagg  ttctagcgc  cataggaga  gatgatgtc  cagtaagaa  660
caacacaga  ggggcagaa  ataacatag  gccactttg  aggtttgtt  atgatacta  720
agataaaag  atgctggtg  ataagtctg  agatatcaa  gatttttca  gtttgcagt  780
tccaaaagt  tgtggttat  taaatgcag  tagtgaaga  ttgcttcca  aagggctca  840
agacagaga  ccatctgaa  agtttgtcc  tcgagtgaa  aggcgagct  aacctaacc  900
attgaagaa  acttgtaaa  tactggtgg  ggcagatca  cgattttat  agtacatgg  960
ccgaggaga  gagagcact  ctacaaatt  cttaataga  ttaattgac  gagttgatg  1020
catataccg  aacacctcg  gggacaatg  aggatttaa  ggttatgga  tacagatag  1080
acagattcg  attctcaag  ctccacaag  ggtaaaacc  ggtgaaaga  acttcaata  1140
ggcaaaaag  tttccaaat  aagaaaagg  tgcttggga  gtgaagatg  tgctggagc  1200
atttagcct  gatatagct  aagaggcct  taaagtctg  ctggctcat  ttttcacct  1260
ccaagattt  gatatggga  ctcttggat  agcttacgt  ggttctccc  gagcaaaca  1320
tcatggagg  gtttgtcca  aagcttatt  caacccagg  gtgaagaag  acatctatt  1380
gaatagtgg  ctgacaagt  caaaaaatt  tggtaaaac  atccttaca  aggaggctg  1440
cctggttac  actcatgaa  tgggacaca  ttttggagc  gaacatgat  ctgatgggc  1500
ggcagagtg  gccccaaat  aggaccaag  aggaaagta  gttatgtac  ccatagctg  1560
gagtggtga  catgagaat  ataagatgt  ttcaaactg  agtaaacag  ccatctaca  1620
gaccataga  agcaaggct  aagagtgct  ccaggagcg  agcaacaag  tgtgcggca  1680
ctccagggt  gacgaagga  aagagtgtg  cccgggcat  atgtacctg  acaacgaca  1740
ctgctgcaa  agtgactgc  cactgaagc  aggtgtgca  tgcagtgat  ggaatagtc  1800
ttgctgtaa  aattgtcag  ttgagacgg  ccagaagaa  tgccaggag  ctatcaatg  1860
tacttgcaa  ggagtgtct  actgcacag  gaatagcag  gagtgcccc  caccaggag  1920
tgctgaaga  gacactgtg  gcttggacc  gggcaagtg  aaggctggg  aatgcatcc  1980
tttctgcaa  agggagcag  agctggagt  ctgcgcatg  gctgacacc  acaactcgt  2040
caaggtatg  tgcaggaac  tttctggcc  atgtgtgcc  tacgtcgat  cagagcaaa  2100
gaacttatt  ttgaggaaa  ggaagccct  tacagtagg  ttttgtgac  tgaatggca  2160
atgtgagaa  cgggtacag  acgtaattg  gcggttttg  gatttcatt  accagctga  2220
catcaacac  tttgggaag  ttctggcag  caacatcgt  gggtctgtt  tggttttct  2280
cttgatatt  tggattcct  tcagcattc  tgtccactg  gtggataag  aactggaca  2340
gcagtatga  tccctgtct  tgtttcatc  cagtaacat  gagatgttg  gcagcatgg  2400
ctcagcatc  gttcgcatt  tcaagccgt  ccctgcacc  cagactcca  gtcgtctgc  2460
ggccctgca  ccggctgca  tgatgccgc  agtgtctgc  gctccaaaa  tggatcacc  2520
gaggatgga  accatccag  aagacccca  cacagattc  catgtggat  atgatggct  2580
tgagaagga  cccttcccc  acagcagtg  agccgccaa  tcctttgag  acctcacag  2640
ccacccagt  accaggagt  agaaggccg  ctccttcaa  ctgcagcgt  agagccgag  2700
tgatagcaa  gagacagag  gttagtggg  gcctgggcc  gctctgggg  acacagacc  2760
acagatgtt  cacagagct  acctgaatc  aaatagact  taatgatct  agaaacggg  2820
gcagcttag  agatgctgg  catgtgaca  gaccttcac  tgacatcct  tgtatgtag  2880
ccctttgaa  aggtgaggt  aatctggct  atttaaggc  ttcaggttt  ggggttttc  2940
tttgtaatc  aaaaatctc  tttgacctg  ggtgcagaa  cagaaaata  ggctggatc  3000
agttcctgg  gacagcact  attaagcct  cagtctgtt  ttctgtatg  tgtaaggtc  3060
tctcactac  gtgaagcac  tagcagtga  gataactgg  acacagact  tttgggggt  3120
ttggccttc  catgtgcgt  gtctccaaa  gccgtctgt  ttggcactg  actttgtgg  3180
tacagtcct  tccaagatg  agactagct  tggaacagt  tatacaaac  gccacatga  3240
cttcaagat  gcctattaa  tgcttagcc  caggttccc  ggacagttt  tccgttttg  3300
aaaaagtgt  ttcacgggt  tctaaacat  gtttgtctt  aaaaatact  ggctggaga  3360
ttggcccca  agttaagag  acttggttt  attcccagt  cccacacgg  ggctcttaa  3420
tccaatccc  ggggagatg  catcttctg  actctagaa  acaaggcat  cattggtgc  3480
gtcaaacat  caggcaaca  acacaaatt  agaaagcca  gtgctgtaa  aagttgcac  3540
tcccccaac  tacagtgct  cgcggtctg  gctggagtg  agctctctc  tgaacactc  3600
ggaaggctg  caggtgctg  gctggctag  gagacgggt  gggcccagc  ctggaagaa  3660
cgtcttcag  ctcagcaag  agacactcg  gttacctca  gctttgggg  ttcaggacc  3720
aggatgttt  gtacttatt  tgtgaggat  aataccatt  gcctgaatt  tcatttctg  3780
aagttttag  tataaaagc  ttttttctt  taagaattg  aatgtgctc  ccagcaaac  3840
cgtcttaac  agaataact  gtaactctg  ggacagtta  ccaaacctg  gccttgtct  3900
tcctgaggg  gtctgttac  ctaatactt  aacatgtac  ttgtggtat  ggctccttt  3960
actagtcat  acagcctta  atgttagtt  cactttgag  atttgctct  aggtgagtg  4020
ggtgtgtgg  tgtatgtat  aatgaaaca  ttggcagaa  ataagaaaa  catttttat  4080
aaattgtga  tttttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4128



<210> 1469
<211> 827
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1K9
<400> 1469

Met Arg Gln Arg Leu Leu Phe Leu Thr Thr Leu Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Glu Glu Pro Gly Ser Gly Ser His Leu Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Ile Arg Lys Arg Asp Leu Gln Ser Ala Thr 
     50                  55                  60
His Leu Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Leu Arg Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Glu Glu Ser Glu Tyr Ser Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Ser Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Gly Asp Asp Asp Val Thr Val Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asp Phe Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Asn Ala Asp Ser Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Ile Asp Arg Glu Pro Ser Glu Glu Phe 
         195                200                205
Val Arg Arg Val Lys Arg Arg Ala Glu Pro Asn Pro Leu Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Lys Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Val Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Arg His Phe Asn Met Ala Lys Ser Phe 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Leu Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Asn Pro Gly Val Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Pro Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asp 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Ala Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Lys Arg Glu Gln Glu Leu Glu Ser Cys Ala 
             580                585                590
Cys Ala Asp Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asn Leu Ser 
         595                600                605
Gly Pro Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His His Ser Asn Ile Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Ala Leu Gln Pro Ala Ala Met Met Pro Pro Val Ser 
             740                745                750
Ala Ala Pro Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp 
         755                760                765
Pro Ser Thr Asp Ser His Val Asp Asp Asp Gly Phe Glu Lys Asp Pro 
     770                775                780
Phe Pro Asn Ser Ser Ala Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp 
 785                790                795                800
His Pro Val Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg 
                 805                810                815
Gln Ser Arg Val Asp Ser Lys Glu Thr Glu Cys 
             820                825



<210> 1470
<211> 2877
<212> DNA
<213> Homo sapiens
<308> U69612
<400> 1470

ggaaaagag  attgagggg  taggccggg  ggatcccgt  ctcccccga  gtgagcagt  60
ttccgaaac  ccgtcaggc  aaggctgcc  agagaggtg  agtcggtag  ggggccggg  120
acatgaggc  gtctctcct  ttcctgacc  gcgtggttc  tttcgtgct  gcgccgcga  180
ctccggatg  cccgggctt  ggcccccac  agagactcg  gaagcttga  tctttgctc  240
cagactacg  tattctctc  ttatctaat  tccagcagc  ttcggtaag  aaaagagat  300
tacagactt  aacacatgt  gaaacacta  taacttttt  agctttgaa  aggcatttt  360
aattatacc  gacatcaag  actgaacgt  tttcacaaa  tttcaaggt  gtggtggtg  420
atggtaaaa  cgaaagcga  tacactgta  aatggcagg  cttcttcac  ggacacgtg  480
ttggtgagc  tgactctag  gttctagcc  acataagag  tgatgatgt  ataatcaga  540
tcaacacag  tggggccga  tataacata  agccacttt  gagatttgt  aatgatacc  600
aagacaaaa  aatgttagt  tataaatct  aagatatca  gaatgtttc  cgtttgcag  660
ctccaaaag  gtgtggtta  ttaaaagtg  ataatgaag  gttgctccc  aaagggtta  720
tagacagag  accacctga  gagcttgtt  atcgagtga  aagaagagc  gacccagat  780
ccatgaaga  cacgtgtaa  ttattggtg  tagcagatc  tcgcttcta  agatacatg  840
gcagagggg  agagagtac  actacaaat  acttaatag  gctaattga  agagttgat  900
acatctatc  gaacacttc  tgggataat  caggtttta  aggctatgg  atacagata  960
agcagattc  cattctcaa  tctccacaa  aggtaaaac  tggtgaaaa  cactacaac  1020
tggcaaaaa  ttacccaaa  gaagaaaag  atgcttggg  tgtgaagat  ttgctagag  1080
aatttagct  tgatatagc  gaggaagca  ctaaagttt  cttggcaca  cttttcaca  1140
accaagatt  tgatatggg  actcttgga  tagcttatg  tggctctcc  agagcaaac  1200
gccatggag  tgtttgtcc  aaggcttat  atagcccag  tgggaagaa  aatatctat  1260
tgaatagtg  tttgacgag  acaaagaat  atggtaaaa  catccttac  aaggaagct  1320
acctggtta  aactcatga  ttgggacat  attttggag  agaacatga  ccggatggt  1380
tagcagaat  tgccccgaa  gaggaccag  gagggaaat  tgtcatgta  cccatagct  1440
tgagtggcg  tcacgagaa  aataagatg  tttcaaact  cagtaaaca  tcaatctat  1500
agaccattg  aagtaaggc  caggagtgt  ttcaagaac  cagcaataa  gtttgtggg  1560
actcgaggg  ggatgaagg  gaagagtgt  atcctggca  catgtatct  aacaacgac  1620
cctgctgca  cagcgactg  acgttgaag  aaggtgtcc  gtgcagtga  aggaacagt  1680
cttgctgta  aaactgtca  tttgagact  cccagaaga  gtgccagga  gcgattaat  1740
ctacttgca  aggcgtgtc  tactgcaca  gtaatagca  tgagtgccc  cctccagga  1800
atgctgaag  tgacactgt  tgcttggat  ttggcaagt  taaggatgg  aaatgcatc  1860
ctttctgcg  gagggaaca  cagctggag  cctgtgcat  taatgaaac  gacaactcc  1920
gcaaggtgt  ctgcaggga  ctttccggc  gctgtgtgc  ctatgtcga  gctgaacaa  1980
agaacttat  tttgaggaa  ggaaagccc  gtacagtag  attttgtga  atgaatggc  2040
aatgtgaga  acgagtaca  gatgtaatt  aacgatttt  ggatttcat  gaccagctg  2100
gcatcaata  ttttggaaa  tttttagca  acaacatcg  tgggtctgt  ctggttttc  2160
ccttgatat  ttggattcc  ttcagcatt  ttgtccatt  tgtgtaacg  cgaaatgct  2220
agcagcatg  attctgcat  ggttcgcat  atcaaaccc  ttcctgcgc  ccagactcc  2280
ggccgcctg  agcctgccc  tgtgatccc  tcggcgcca  cagctccaa  actggacca  2340
cagagaatg  acaccatcc  ggaagaccc  agcacagac  cacatatgg  cgaggatgg  2400
tttgagaag  accccttcc  aaatagcag  acagctgcc  agtcatttg  ggatctcac  2460
gaccatccg  tcaccagaa  tgaaaaggc  gcctccttt  aactgcagc  tcagaatcg  2520
gttgacagc  aagaaacag  gtgctaatt  agttctcag  tcttctgac  taagtgtgc  2580
aaatatttt  atagatttg  cctacaatc  atcacagct  atattttgt  aagactggg  2640
agtgactta  cagatgctg  tcatgtgtt  gaacttcct  caggtaaac  gttcttgtg  2700
ggtttggcc  ttctccttt  gaaaaggta  ggtgaaggt  aatctagct  attttgagg  2760
tttcaggtt  tagttttta  aatatcttt  gacctgtgg  gcaaaagca  aaaatacag  2820
tggattggg  tatgagtat  tacgttttt  taaattaat  ttttatatt  ataacag  2877



<210> 1471
<211> 824
<212> PRT
<213> Homo sapiens
<308> P78536
<400> 1471

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
     50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
         195                200                205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
             580                585                590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
         595                600                605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
             740                745                750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
         755                760                765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
     770                775                780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
 785                790                795                800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                 805                810                815
Val Asp Ser Lys Glu Thr Glu Cys 
             820



<210> 1472
<211> 4128
<212> DNA
<213> Rattus norvegicus
<308> AJ012603
<400> 1472

ggttccggc  gtgggcagc  gggtggtcc  cgactgcgg  cggaagcag  ctgagcggc  60
ctcggcgag  gccgcctgt  cttccgggg  cttcagcct  gctcttgag  tttccctgt  120
ggcggcgcg  gagggaaaa  tttgcaggg  cgtgctggg  agatcacct  cgcttccca  180
tgtgagcag  ttctcgaac  ctctctcta  aaggttgcc  agagaggtg  tggacggga  240
catgaggca  cgtctcctc  tcctgacca  tttggtgcc  ttcgtcctg  caccccgac  300
tccggagga  ccaggctct  gctcccacc  gcgacttga  aagcttgat  ctttgctct  360
agactacga  atcctctct  tatctaata  ccagcagca  tccataagg  aaagggatc  420
acagtctgc  acacactta  aaacactac  aactttttc  gctttgaaa  ggcatttta  480
attatactt  acatcaagt  cagaacgct  ttcacagaa  ttgcgagtc  tggtggtgg  540
tgggaaaga  gaaagcgag  acagtgtga  gtggcagga  ttcttcagc  gacatgtgg  600
tggtgagcc  gactctagg  ttctagcgc  cataggaga  gatgatgtc  cagtaagaa  660
caacacaga  ggggcagaa  ataacatag  gccactttg  aggtttgtt  atgatacta  720
agataaaag  atgctggtg  ataagtctg  agatatcaa  gatttttca  gtttgcagt  780
tccaaaagt  tgtggttat  taaatgcag  tagtgaaga  ttgcttcca  aagggctca  840
agacagaga  ccatctgaa  agtttgtcc  tcgagtgaa  aggcgagct  aacctaacc  900
attgaagaa  acttgtaaa  tactggtgg  ggcagatca  cgattttat  agtacatgg  960
ccgaggaga  gagagcact  ctacaaatt  cttaataga  ttaattgac  gagttgatg  1020
catataccg  aacacctcg  gggacaatg  aggatttaa  ggttatgga  tacagatag  1080
acagattcg  attctcaag  ctccacaag  ggtaaaacc  ggtgaaaga  acttcaata  1140
ggcaaaaag  tttccaaat  aagaaaagg  tgcttggga  gtgaagatg  tgctggagc  1200
atttagcct  gatatagct  aagaggcct  taaagtctg  ctggctcat  ttttcacct  1260
ccaagattt  gatatggga  ctcttggat  agcttacgt  ggttctccc  gagcaaaca  1320
tcatggagg  gtttgtcca  aagcttatt  caacccagg  gtgaagaag  acatctatt  1380
gaatagtgg  ctgacaagt  caaaaaatt  tggtaaaac  atccttaca  aggaggctg  1440
cctggttac  actcatgaa  tgggacaca  ttttggagc  gaacatgat  ctgatgggc  1500
ggcagagtg  gccccaaat  aggaccaag  aggaaagta  gttatgtac  ccatagctg  1560
gagtggtga  catgagaat  ataagatgt  ttcaaactg  agtaaacag  ccatctaca  1620
gaccataga  agcaaggct  aagagtgct  ccaggagcg  agcaacaag  tgtgcggca  1680
ctccagggt  gacgaagga  aagagtgtg  cccgggcat  atgtacctg  acaacgaca  1740
ctgctgcaa  agtgactgc  cactgaagc  aggtgtgca  tgcagtgat  ggaatagtc  1800
ttgctgtaa  aattgtcag  ttgagacgg  ccagaagaa  tgccaggag  ctatcaatg  1860
tacttgcaa  ggagtgtct  actgcacag  gaatagcag  gagtgcccc  caccaggag  1920
tgctgaaga  gacactgtg  gcttggacc  gggcaagtg  aaggctggg  aatgcatcc  1980
tttctgcaa  agggagcag  agctggagt  ctgcgcatg  gctgacacc  acaactcgt  2040
caaggtatg  tgcaggaac  tttctggcc  atgtgtgcc  tacgtcgat  cagagcaaa  2100
gaacttatt  ttgaggaaa  ggaagccct  tacagtagg  ttttgtgac  tgaatggca  2160
atgtgagaa  cgggtacag  acgtaattg  gcggttttg  gatttcatt  accagctga  2220
catcaacac  tttgggaag  ttctggcag  caacatcgt  gggtctgtt  tggttttct  2280
cttgatatt  tggattcct  tcagcattc  tgtccactg  gtggataag  aactggaca  2340
gcagtatga  tccctgtct  tgtttcatc  cagtaacat  gagatgttg  gcagcatgg  2400
ctcagcatc  gttcgcatt  tcaagccgt  ccctgcacc  cagactcca  gtcgtctgc  2460
ggccctgca  ccggctgca  tgatgccgc  agtgtctgc  gctccaaaa  tggatcacc  2520
gaggatgga  accatccag  aagacccca  cacagattc  catgtggat  atgatggct  2580
tgagaagga  cccttcccc  acagcagtg  agccgccaa  tcctttgag  acctcacag  2640
ccacccagt  accaggagt  agaaggccg  ctccttcaa  ctgcagcgt  agagccgag  2700
tgatagcaa  gagacagag  gttagtggg  gcctgggcc  gctctgggg  acacagacc  2760
acagatgtt  cacagagct  acctgaatc  aaatagact  taatgatct  agaaacggg  2820
gcagcttag  agatgctgg  catgtgaca  gaccttcac  tgacatcct  tgtatgtag  2880
ccctttgaa  aggtgaggt  aatctggct  atttaaggc  ttcaggttt  ggggttttc  2940
tttgtaatc  aaaaatctc  tttgacctg  ggtgcagaa  cagaaaata  ggctggatc  3000
agttcctgg  gacagcact  attaagcct  cagtctgtt  ttctgtatg  tgtaaggtc  3060
tctcactac  gtgaagcac  tagcagtga  gataactgg  acacagact  tttgggggt  3120
ttggccttc  catgtgcgt  gtctccaaa  gccgtctgt  ttggcactg  actttgtgg  3180
tacagtcct  tccaagatg  agactagct  tggaacagt  tatacaaac  gccacatga  3240
cttcaagat  gcctattaa  tgcttagcc  caggttccc  ggacagttt  tccgttttg  3300
aaaaagtgt  ttcacgggt  tctaaacat  gtttgtctt  aaaaatact  ggctggaga  3360
ttggcccca  agttaagag  acttggttt  attcccagt  cccacacgg  ggctcttaa  3420
tccaatccc  ggggagatg  catcttctg  actctagaa  acaaggcat  cattggtgc  3480
gtcaaacat  caggcaaca  acacaaatt  agaaagcca  gtgctgtaa  aagttgcac  3540
tcccccaac  tacagtgct  cgcggtctg  gctggagtg  agctctctc  tgaacactc  3600
ggaaggctg  caggtgctg  gctggctag  gagacgggt  gggcccagc  ctggaagaa  3660
cgtcttcag  ctcagcaag  agacactcg  gttacctca  gctttgggg  ttcaggacc  3720
aggatgttt  gtacttatt  tgtgaggat  aataccatt  gcctgaatt  tcatttctg  3780
aagttttag  tataaaagc  ttttttctt  taagaattg  aatgtgctc  ccagcaaac  3840
cgtcttaac  agaataact  gtaactctg  ggacagtta  ccaaacctg  gccttgtct  3900
tcctgaggg  gtctgttac  ctaatactt  aacatgtac  ttgtggtat  ggctccttt  3960
actagtcat  acagcctta  atgttagtt  cactttgag  atttgctct  aggtgagtg  4020
ggtgtgtgg  tgtatgtat  aatgaaaca  ttggcagaa  ataagaaaa  catttttat  4080
aaattgtga  tttttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4128



<210> 1473
<211> 827
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1K9
<400> 1473

Met Arg Gln Arg Leu Leu Phe Leu Thr Thr Leu Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Glu Glu Pro Gly Ser Gly Ser His Leu Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Ile Arg Lys Arg Asp Leu Gln Ser Ala Thr 
     50                  55                  60
His Leu Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Leu Arg Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Glu Glu Ser Glu Tyr Ser Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Ser Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Gly Asp Asp Asp Val Thr Val Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asp Phe Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Asn Ala Asp Ser Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Ile Asp Arg Glu Pro Ser Glu Glu Phe 
         195                200                205
Val Arg Arg Val Lys Arg Arg Ala Glu Pro Asn Pro Leu Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Lys Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Val Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Arg His Phe Asn Met Ala Lys Ser Phe 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Leu Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Asn Pro Gly Val Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Pro Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asp 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Ala Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Lys Arg Glu Gln Glu Leu Glu Ser Cys Ala 
             580                585                590
Cys Ala Asp Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asn Leu Ser 
         595                600                605
Gly Pro Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His His Ser Asn Ile Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Ala Leu Gln Pro Ala Ala Met Met Pro Pro Val Ser 
             740                745                750
Ala Ala Pro Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp 
         755                760                765
Pro Ser Thr Asp Ser His Val Asp Asp Asp Gly Phe Glu Lys Asp Pro 
     770                775                780
Phe Pro Asn Ser Ser Ala Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp 
 785                790                795                800
His Pro Val Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg 
                 805                810                815
Gln Ser Arg Val Asp Ser Lys Glu Thr Glu Cys 
             820                825



<210> 1474
<211> 2877
<212> DNA
<213> Homo sapiens
<308> U69612
<400> 1474

ggaaaagag  attgagggg  taggccggg  ggatcccgt  ctcccccga  gtgagcagt  60
ttccgaaac  ccgtcaggc  aaggctgcc  agagaggtg  agtcggtag  ggggccggg  120
acatgaggc  gtctctcct  ttcctgacc  gcgtggttc  tttcgtgct  gcgccgcga  180
ctccggatg  cccgggctt  ggcccccac  agagactcg  gaagcttga  tctttgctc  240
cagactacg  tattctctc  ttatctaat  tccagcagc  ttcggtaag  aaaagagat  300
tacagactt  aacacatgt  gaaacacta  taacttttt  agctttgaa  aggcatttt  360
aattatacc  gacatcaag  actgaacgt  tttcacaaa  tttcaaggt  gtggtggtg  420
atggtaaaa  cgaaagcga  tacactgta  aatggcagg  cttcttcac  ggacacgtg  480
ttggtgagc  tgactctag  gttctagcc  acataagag  tgatgatgt  ataatcaga  540
tcaacacag  tggggccga  tataacata  agccacttt  gagatttgt  aatgatacc  600
aagacaaaa  aatgttagt  tataaatct  aagatatca  gaatgtttc  cgtttgcag  660
ctccaaaag  gtgtggtta  ttaaaagtg  ataatgaag  gttgctccc  aaagggtta  720
tagacagag  accacctga  gagcttgtt  atcgagtga  aagaagagc  gacccagat  780
ccatgaaga  cacgtgtaa  ttattggtg  tagcagatc  tcgcttcta  agatacatg  840
gcagagggg  agagagtac  actacaaat  acttaatag  gctaattga  agagttgat  900
acatctatc  gaacacttc  tgggataat  caggtttta  aggctatgg  atacagata  960
agcagattc  cattctcaa  tctccacaa  aggtaaaac  tggtgaaaa  cactacaac  1020
tggcaaaaa  ttacccaaa  gaagaaaag  atgcttggg  tgtgaagat  ttgctagag  1080
aatttagct  tgatatagc  gaggaagca  ctaaagttt  cttggcaca  cttttcaca  1140
accaagatt  tgatatggg  actcttgga  tagcttatg  tggctctcc  agagcaaac  1200
gccatggag  tgtttgtcc  aaggcttat  atagcccag  tgggaagaa  aatatctat  1260
tgaatagtg  tttgacgag  acaaagaat  atggtaaaa  catccttac  aaggaagct  1320
acctggtta  aactcatga  ttgggacat  attttggag  agaacatga  ccggatggt  1380
tagcagaat  tgccccgaa  gaggaccag  gagggaaat  tgtcatgta  cccatagct  1440
tgagtggcg  tcacgagaa  aataagatg  tttcaaact  cagtaaaca  tcaatctat  1500
agaccattg  aagtaaggc  caggagtgt  ttcaagaac  cagcaataa  gtttgtggg  1560
actcgaggg  ggatgaagg  gaagagtgt  atcctggca  catgtatct  aacaacgac  1620
cctgctgca  cagcgactg  acgttgaag  aaggtgtcc  gtgcagtga  aggaacagt  1680
cttgctgta  aaactgtca  tttgagact  cccagaaga  gtgccagga  gcgattaat  1740
ctacttgca  aggcgtgtc  tactgcaca  gtaatagca  tgagtgccc  cctccagga  1800
atgctgaag  tgacactgt  tgcttggat  ttggcaagt  taaggatgg  aaatgcatc  1860
ctttctgcg  gagggaaca  cagctggag  cctgtgcat  taatgaaac  gacaactcc  1920
gcaaggtgt  ctgcaggga  ctttccggc  gctgtgtgc  ctatgtcga  gctgaacaa  1980
agaacttat  tttgaggaa  ggaaagccc  gtacagtag  attttgtga  atgaatggc  2040
aatgtgaga  acgagtaca  gatgtaatt  aacgatttt  ggatttcat  gaccagctg  2100
gcatcaata  ttttggaaa  tttttagca  acaacatcg  tgggtctgt  ctggttttc  2160
ccttgatat  ttggattcc  ttcagcatt  ttgtccatt  tgtgtaacg  cgaaatgct  2220
agcagcatg  attctgcat  ggttcgcat  atcaaaccc  ttcctgcgc  ccagactcc  2280
ggccgcctg  agcctgccc  tgtgatccc  tcggcgcca  cagctccaa  actggacca  2340
cagagaatg  acaccatcc  ggaagaccc  agcacagac  cacatatgg  cgaggatgg  2400
tttgagaag  accccttcc  aaatagcag  acagctgcc  agtcatttg  ggatctcac  2460
gaccatccg  tcaccagaa  tgaaaaggc  gcctccttt  aactgcagc  tcagaatcg  2520
gttgacagc  aagaaacag  gtgctaatt  agttctcag  tcttctgac  taagtgtgc  2580
aaatatttt  atagatttg  cctacaatc  atcacagct  atattttgt  aagactggg  2640
agtgactta  cagatgctg  tcatgtgtt  gaacttcct  caggtaaac  gttcttgtg  2700
ggtttggcc  ttctccttt  gaaaaggta  ggtgaaggt  aatctagct  attttgagg  2760
tttcaggtt  tagttttta  aatatcttt  gacctgtgg  gcaaaagca  aaaatacag  2820
tggattggg  tatgagtat  tacgttttt  taaattaat  ttttatatt  ataacag  2877



<210> 1475
<211> 824
<212> PRT
<213> Homo sapiens
<308> P78536
<400> 1475

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
     50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
         195                200                205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
             580                585                590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
         595                600                605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
             740                745                750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
         755                760                765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
     770                775                780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
 785                790                795                800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                 805                810                815
Val Asp Ser Lys Glu Thr Glu Cys 
             820



<210> 1476
<211> 4128
<212> DNA
<213> Rattus norvegicus
<308> AJ012603
<400> 1476

ggttccggc  gtgggcagc  gggtggtcc  cgactgcgg  cggaagcag  ctgagcggc  60
ctcggcgag  gccgcctgt  cttccgggg  cttcagcct  gctcttgag  tttccctgt  120
ggcggcgcg  gagggaaaa  tttgcaggg  cgtgctggg  agatcacct  cgcttccca  180
tgtgagcag  ttctcgaac  ctctctcta  aaggttgcc  agagaggtg  tggacggga  240
catgaggca  cgtctcctc  tcctgacca  tttggtgcc  ttcgtcctg  caccccgac  300
tccggagga  ccaggctct  gctcccacc  gcgacttga  aagcttgat  ctttgctct  360
agactacga  atcctctct  tatctaata  ccagcagca  tccataagg  aaagggatc  420
acagtctgc  acacactta  aaacactac  aactttttc  gctttgaaa  ggcatttta  480
attatactt  acatcaagt  cagaacgct  ttcacagaa  ttgcgagtc  tggtggtgg  540
tgggaaaga  gaaagcgag  acagtgtga  gtggcagga  ttcttcagc  gacatgtgg  600
tggtgagcc  gactctagg  ttctagcgc  cataggaga  gatgatgtc  cagtaagaa  660
caacacaga  ggggcagaa  ataacatag  gccactttg  aggtttgtt  atgatacta  720
agataaaag  atgctggtg  ataagtctg  agatatcaa  gatttttca  gtttgcagt  780
tccaaaagt  tgtggttat  taaatgcag  tagtgaaga  ttgcttcca  aagggctca  840
agacagaga  ccatctgaa  agtttgtcc  tcgagtgaa  aggcgagct  aacctaacc  900
attgaagaa  acttgtaaa  tactggtgg  ggcagatca  cgattttat  agtacatgg  960
ccgaggaga  gagagcact  ctacaaatt  cttaataga  ttaattgac  gagttgatg  1020
catataccg  aacacctcg  gggacaatg  aggatttaa  ggttatgga  tacagatag  1080
acagattcg  attctcaag  ctccacaag  ggtaaaacc  ggtgaaaga  acttcaata  1140
ggcaaaaag  tttccaaat  aagaaaagg  tgcttggga  gtgaagatg  tgctggagc  1200
atttagcct  gatatagct  aagaggcct  taaagtctg  ctggctcat  ttttcacct  1260
ccaagattt  gatatggga  ctcttggat  agcttacgt  ggttctccc  gagcaaaca  1320
tcatggagg  gtttgtcca  aagcttatt  caacccagg  gtgaagaag  acatctatt  1380
gaatagtgg  ctgacaagt  caaaaaatt  tggtaaaac  atccttaca  aggaggctg  1440
cctggttac  actcatgaa  tgggacaca  ttttggagc  gaacatgat  ctgatgggc  1500
ggcagagtg  gccccaaat  aggaccaag  aggaaagta  gttatgtac  ccatagctg  1560
gagtggtga  catgagaat  ataagatgt  ttcaaactg  agtaaacag  ccatctaca  1620
gaccataga  agcaaggct  aagagtgct  ccaggagcg  agcaacaag  tgtgcggca  1680
ctccagggt  gacgaagga  aagagtgtg  cccgggcat  atgtacctg  acaacgaca  1740
ctgctgcaa  agtgactgc  cactgaagc  aggtgtgca  tgcagtgat  ggaatagtc  1800
ttgctgtaa  aattgtcag  ttgagacgg  ccagaagaa  tgccaggag  ctatcaatg  1860
tacttgcaa  ggagtgtct  actgcacag  gaatagcag  gagtgcccc  caccaggag  1920
tgctgaaga  gacactgtg  gcttggacc  gggcaagtg  aaggctggg  aatgcatcc  1980
tttctgcaa  agggagcag  agctggagt  ctgcgcatg  gctgacacc  acaactcgt  2040
caaggtatg  tgcaggaac  tttctggcc  atgtgtgcc  tacgtcgat  cagagcaaa  2100
gaacttatt  ttgaggaaa  ggaagccct  tacagtagg  ttttgtgac  tgaatggca  2160
atgtgagaa  cgggtacag  acgtaattg  gcggttttg  gatttcatt  accagctga  2220
catcaacac  tttgggaag  ttctggcag  caacatcgt  gggtctgtt  tggttttct  2280
cttgatatt  tggattcct  tcagcattc  tgtccactg  gtggataag  aactggaca  2340
gcagtatga  tccctgtct  tgtttcatc  cagtaacat  gagatgttg  gcagcatgg  2400
ctcagcatc  gttcgcatt  tcaagccgt  ccctgcacc  cagactcca  gtcgtctgc  2460
ggccctgca  ccggctgca  tgatgccgc  agtgtctgc  gctccaaaa  tggatcacc  2520
gaggatgga  accatccag  aagacccca  cacagattc  catgtggat  atgatggct  2580
tgagaagga  cccttcccc  acagcagtg  agccgccaa  tcctttgag  acctcacag  2640
ccacccagt  accaggagt  agaaggccg  ctccttcaa  ctgcagcgt  agagccgag  2700
tgatagcaa  gagacagag  gttagtggg  gcctgggcc  gctctgggg  acacagacc  2760
acagatgtt  cacagagct  acctgaatc  aaatagact  taatgatct  agaaacggg  2820
gcagcttag  agatgctgg  catgtgaca  gaccttcac  tgacatcct  tgtatgtag  2880
ccctttgaa  aggtgaggt  aatctggct  atttaaggc  ttcaggttt  ggggttttc  2940
tttgtaatc  aaaaatctc  tttgacctg  ggtgcagaa  cagaaaata  ggctggatc  3000
agttcctgg  gacagcact  attaagcct  cagtctgtt  ttctgtatg  tgtaaggtc  3060
tctcactac  gtgaagcac  tagcagtga  gataactgg  acacagact  tttgggggt  3120
ttggccttc  catgtgcgt  gtctccaaa  gccgtctgt  ttggcactg  actttgtgg  3180
tacagtcct  tccaagatg  agactagct  tggaacagt  tatacaaac  gccacatga  3240
cttcaagat  gcctattaa  tgcttagcc  caggttccc  ggacagttt  tccgttttg  3300
aaaaagtgt  ttcacgggt  tctaaacat  gtttgtctt  aaaaatact  ggctggaga  3360
ttggcccca  agttaagag  acttggttt  attcccagt  cccacacgg  ggctcttaa  3420
tccaatccc  ggggagatg  catcttctg  actctagaa  acaaggcat  cattggtgc  3480
gtcaaacat  caggcaaca  acacaaatt  agaaagcca  gtgctgtaa  aagttgcac  3540
tcccccaac  tacagtgct  cgcggtctg  gctggagtg  agctctctc  tgaacactc  3600
ggaaggctg  caggtgctg  gctggctag  gagacgggt  gggcccagc  ctggaagaa  3660
cgtcttcag  ctcagcaag  agacactcg  gttacctca  gctttgggg  ttcaggacc  3720
aggatgttt  gtacttatt  tgtgaggat  aataccatt  gcctgaatt  tcatttctg  3780
aagttttag  tataaaagc  ttttttctt  taagaattg  aatgtgctc  ccagcaaac  3840
cgtcttaac  agaataact  gtaactctg  ggacagtta  ccaaacctg  gccttgtct  3900
tcctgaggg  gtctgttac  ctaatactt  aacatgtac  ttgtggtat  ggctccttt  3960
actagtcat  acagcctta  atgttagtt  cactttgag  atttgctct  aggtgagtg  4020
ggtgtgtgg  tgtatgtat  aatgaaaca  ttggcagaa  ataagaaaa  catttttat  4080
aaattgtga  tttttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4128



<210> 1477
<211> 827
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1K9
<400> 1477

Met Arg Gln Arg Leu Leu Phe Leu Thr Thr Leu Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Glu Glu Pro Gly Ser Gly Ser His Leu Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Ile Arg Lys Arg Asp Leu Gln Ser Ala Thr 
     50                  55                  60
His Leu Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Leu Arg Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Glu Glu Ser Glu Tyr Ser Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Ser Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Gly Asp Asp Asp Val Thr Val Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asp Phe Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Asn Ala Asp Ser Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Ile Asp Arg Glu Pro Ser Glu Glu Phe 
         195                200                205
Val Arg Arg Val Lys Arg Arg Ala Glu Pro Asn Pro Leu Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Lys Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Val Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Arg His Phe Asn Met Ala Lys Ser Phe 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Leu Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Asn Pro Gly Val Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Pro Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asp 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Ala Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Lys Arg Glu Gln Glu Leu Glu Ser Cys Ala 
             580                585                590
Cys Ala Asp Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asn Leu Ser 
         595                600                605
Gly Pro Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His His Ser Asn Ile Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Ala Leu Gln Pro Ala Ala Met Met Pro Pro Val Ser 
             740                745                750
Ala Ala Pro Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp 
         755                760                765
Pro Ser Thr Asp Ser His Val Asp Asp Asp Gly Phe Glu Lys Asp Pro 
     770                775                780
Phe Pro Asn Ser Ser Ala Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp 
 785                790                795                800
His Pro Val Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg 
                 805                810                815
Gln Ser Arg Val Asp Ser Lys Glu Thr Glu Cys 
             820                825



<210> 1478
<211> 2877
<212> DNA
<213> Homo sapiens
<308> U69612
<400> 1478

ggaaaagag  attgagggg  taggccggg  ggatcccgt  ctcccccga  gtgagcagt  60
ttccgaaac  ccgtcaggc  aaggctgcc  agagaggtg  agtcggtag  ggggccggg  120
acatgaggc  gtctctcct  ttcctgacc  gcgtggttc  tttcgtgct  gcgccgcga  180
ctccggatg  cccgggctt  ggcccccac  agagactcg  gaagcttga  tctttgctc  240
cagactacg  tattctctc  ttatctaat  tccagcagc  ttcggtaag  aaaagagat  300
tacagactt  aacacatgt  gaaacacta  taacttttt  agctttgaa  aggcatttt  360
aattatacc  gacatcaag  actgaacgt  tttcacaaa  tttcaaggt  gtggtggtg  420
atggtaaaa  cgaaagcga  tacactgta  aatggcagg  cttcttcac  ggacacgtg  480
ttggtgagc  tgactctag  gttctagcc  acataagag  tgatgatgt  ataatcaga  540
tcaacacag  tggggccga  tataacata  agccacttt  gagatttgt  aatgatacc  600
aagacaaaa  aatgttagt  tataaatct  aagatatca  gaatgtttc  cgtttgcag  660
ctccaaaag  gtgtggtta  ttaaaagtg  ataatgaag  gttgctccc  aaagggtta  720
tagacagag  accacctga  gagcttgtt  atcgagtga  aagaagagc  gacccagat  780
ccatgaaga  cacgtgtaa  ttattggtg  tagcagatc  tcgcttcta  agatacatg  840
gcagagggg  agagagtac  actacaaat  acttaatag  gctaattga  agagttgat  900
acatctatc  gaacacttc  tgggataat  caggtttta  aggctatgg  atacagata  960
agcagattc  cattctcaa  tctccacaa  aggtaaaac  tggtgaaaa  cactacaac  1020
tggcaaaaa  ttacccaaa  gaagaaaag  atgcttggg  tgtgaagat  ttgctagag  1080
aatttagct  tgatatagc  gaggaagca  ctaaagttt  cttggcaca  cttttcaca  1140
accaagatt  tgatatggg  actcttgga  tagcttatg  tggctctcc  agagcaaac  1200
gccatggag  tgtttgtcc  aaggcttat  atagcccag  tgggaagaa  aatatctat  1260
tgaatagtg  tttgacgag  acaaagaat  atggtaaaa  catccttac  aaggaagct  1320
acctggtta  aactcatga  ttgggacat  attttggag  agaacatga  ccggatggt  1380
tagcagaat  tgccccgaa  gaggaccag  gagggaaat  tgtcatgta  cccatagct  1440
tgagtggcg  tcacgagaa  aataagatg  tttcaaact  cagtaaaca  tcaatctat  1500
agaccattg  aagtaaggc  caggagtgt  ttcaagaac  cagcaataa  gtttgtggg  1560
actcgaggg  ggatgaagg  gaagagtgt  atcctggca  catgtatct  aacaacgac  1620
cctgctgca  cagcgactg  acgttgaag  aaggtgtcc  gtgcagtga  aggaacagt  1680
cttgctgta  aaactgtca  tttgagact  cccagaaga  gtgccagga  gcgattaat  1740
ctacttgca  aggcgtgtc  tactgcaca  gtaatagca  tgagtgccc  cctccagga  1800
atgctgaag  tgacactgt  tgcttggat  ttggcaagt  taaggatgg  aaatgcatc  1860
ctttctgcg  gagggaaca  cagctggag  cctgtgcat  taatgaaac  gacaactcc  1920
gcaaggtgt  ctgcaggga  ctttccggc  gctgtgtgc  ctatgtcga  gctgaacaa  1980
agaacttat  tttgaggaa  ggaaagccc  gtacagtag  attttgtga  atgaatggc  2040
aatgtgaga  acgagtaca  gatgtaatt  aacgatttt  ggatttcat  gaccagctg  2100
gcatcaata  ttttggaaa  tttttagca  acaacatcg  tgggtctgt  ctggttttc  2160
ccttgatat  ttggattcc  ttcagcatt  ttgtccatt  tgtgtaacg  cgaaatgct  2220
agcagcatg  attctgcat  ggttcgcat  atcaaaccc  ttcctgcgc  ccagactcc  2280
ggccgcctg  agcctgccc  tgtgatccc  tcggcgcca  cagctccaa  actggacca  2340
cagagaatg  acaccatcc  ggaagaccc  agcacagac  cacatatgg  cgaggatgg  2400
tttgagaag  accccttcc  aaatagcag  acagctgcc  agtcatttg  ggatctcac  2460
gaccatccg  tcaccagaa  tgaaaaggc  gcctccttt  aactgcagc  tcagaatcg  2520
gttgacagc  aagaaacag  gtgctaatt  agttctcag  tcttctgac  taagtgtgc  2580
aaatatttt  atagatttg  cctacaatc  atcacagct  atattttgt  aagactggg  2640
agtgactta  cagatgctg  tcatgtgtt  gaacttcct  caggtaaac  gttcttgtg  2700
ggtttggcc  ttctccttt  gaaaaggta  ggtgaaggt  aatctagct  attttgagg  2760
tttcaggtt  tagttttta  aatatcttt  gacctgtgg  gcaaaagca  aaaatacag  2820
tggattggg  tatgagtat  tacgttttt  taaattaat  ttttatatt  ataacag  2877



<210> 1479
<211> 824
<212> PRT
<213> Homo sapiens
<308> P78536
<400> 1479

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
     50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
         195                200                205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
             580                585                590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
         595                600                605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
             740                745                750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
         755                760                765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
     770                775                780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
 785                790                795                800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                 805                810                815
Val Asp Ser Lys Glu Thr Glu Cys 
             820



<210> 1480
<211> 4128
<212> DNA
<213> Rattus norvegicus
<308> AJ012603
<400> 1480

ggttccggc  gtgggcagc  gggtggtcc  cgactgcgg  cggaagcag  ctgagcggc  60
ctcggcgag  gccgcctgt  cttccgggg  cttcagcct  gctcttgag  tttccctgt  120
ggcggcgcg  gagggaaaa  tttgcaggg  cgtgctggg  agatcacct  cgcttccca  180
tgtgagcag  ttctcgaac  ctctctcta  aaggttgcc  agagaggtg  tggacggga  240
catgaggca  cgtctcctc  tcctgacca  tttggtgcc  ttcgtcctg  caccccgac  300
tccggagga  ccaggctct  gctcccacc  gcgacttga  aagcttgat  ctttgctct  360
agactacga  atcctctct  tatctaata  ccagcagca  tccataagg  aaagggatc  420
acagtctgc  acacactta  aaacactac  aactttttc  gctttgaaa  ggcatttta  480
attatactt  acatcaagt  cagaacgct  ttcacagaa  ttgcgagtc  tggtggtgg  540
tgggaaaga  gaaagcgag  acagtgtga  gtggcagga  ttcttcagc  gacatgtgg  600
tggtgagcc  gactctagg  ttctagcgc  cataggaga  gatgatgtc  cagtaagaa  660
caacacaga  ggggcagaa  ataacatag  gccactttg  aggtttgtt  atgatacta  720
agataaaag  atgctggtg  ataagtctg  agatatcaa  gatttttca  gtttgcagt  780
tccaaaagt  tgtggttat  taaatgcag  tagtgaaga  ttgcttcca  aagggctca  840
agacagaga  ccatctgaa  agtttgtcc  tcgagtgaa  aggcgagct  aacctaacc  900
attgaagaa  acttgtaaa  tactggtgg  ggcagatca  cgattttat  agtacatgg  960
ccgaggaga  gagagcact  ctacaaatt  cttaataga  ttaattgac  gagttgatg  1020
catataccg  aacacctcg  gggacaatg  aggatttaa  ggttatgga  tacagatag  1080
acagattcg  attctcaag  ctccacaag  ggtaaaacc  ggtgaaaga  acttcaata  1140
ggcaaaaag  tttccaaat  aagaaaagg  tgcttggga  gtgaagatg  tgctggagc  1200
atttagcct  gatatagct  aagaggcct  taaagtctg  ctggctcat  ttttcacct  1260
ccaagattt  gatatggga  ctcttggat  agcttacgt  ggttctccc  gagcaaaca  1320
tcatggagg  gtttgtcca  aagcttatt  caacccagg  gtgaagaag  acatctatt  1380
gaatagtgg  ctgacaagt  caaaaaatt  tggtaaaac  atccttaca  aggaggctg  1440
cctggttac  actcatgaa  tgggacaca  ttttggagc  gaacatgat  ctgatgggc  1500
ggcagagtg  gccccaaat  aggaccaag  aggaaagta  gttatgtac  ccatagctg  1560
gagtggtga  catgagaat  ataagatgt  ttcaaactg  agtaaacag  ccatctaca  1620
gaccataga  agcaaggct  aagagtgct  ccaggagcg  agcaacaag  tgtgcggca  1680
ctccagggt  gacgaagga  aagagtgtg  cccgggcat  atgtacctg  acaacgaca  1740
ctgctgcaa  agtgactgc  cactgaagc  aggtgtgca  tgcagtgat  ggaatagtc  1800
ttgctgtaa  aattgtcag  ttgagacgg  ccagaagaa  tgccaggag  ctatcaatg  1860
tacttgcaa  ggagtgtct  actgcacag  gaatagcag  gagtgcccc  caccaggag  1920
tgctgaaga  gacactgtg  gcttggacc  gggcaagtg  aaggctggg  aatgcatcc  1980
tttctgcaa  agggagcag  agctggagt  ctgcgcatg  gctgacacc  acaactcgt  2040
caaggtatg  tgcaggaac  tttctggcc  atgtgtgcc  tacgtcgat  cagagcaaa  2100
gaacttatt  ttgaggaaa  ggaagccct  tacagtagg  ttttgtgac  tgaatggca  2160
atgtgagaa  cgggtacag  acgtaattg  gcggttttg  gatttcatt  accagctga  2220
catcaacac  tttgggaag  ttctggcag  caacatcgt  gggtctgtt  tggttttct  2280
cttgatatt  tggattcct  tcagcattc  tgtccactg  gtggataag  aactggaca  2340
gcagtatga  tccctgtct  tgtttcatc  cagtaacat  gagatgttg  gcagcatgg  2400
ctcagcatc  gttcgcatt  tcaagccgt  ccctgcacc  cagactcca  gtcgtctgc  2460
ggccctgca  ccggctgca  tgatgccgc  agtgtctgc  gctccaaaa  tggatcacc  2520
gaggatgga  accatccag  aagacccca  cacagattc  catgtggat  atgatggct  2580
tgagaagga  cccttcccc  acagcagtg  agccgccaa  tcctttgag  acctcacag  2640
ccacccagt  accaggagt  agaaggccg  ctccttcaa  ctgcagcgt  agagccgag  2700
tgatagcaa  gagacagag  gttagtggg  gcctgggcc  gctctgggg  acacagacc  2760
acagatgtt  cacagagct  acctgaatc  aaatagact  taatgatct  agaaacggg  2820
gcagcttag  agatgctgg  catgtgaca  gaccttcac  tgacatcct  tgtatgtag  2880
ccctttgaa  aggtgaggt  aatctggct  atttaaggc  ttcaggttt  ggggttttc  2940
tttgtaatc  aaaaatctc  tttgacctg  ggtgcagaa  cagaaaata  ggctggatc  3000
agttcctgg  gacagcact  attaagcct  cagtctgtt  ttctgtatg  tgtaaggtc  3060
tctcactac  gtgaagcac  tagcagtga  gataactgg  acacagact  tttgggggt  3120
ttggccttc  catgtgcgt  gtctccaaa  gccgtctgt  ttggcactg  actttgtgg  3180
tacagtcct  tccaagatg  agactagct  tggaacagt  tatacaaac  gccacatga  3240
cttcaagat  gcctattaa  tgcttagcc  caggttccc  ggacagttt  tccgttttg  3300
aaaaagtgt  ttcacgggt  tctaaacat  gtttgtctt  aaaaatact  ggctggaga  3360
ttggcccca  agttaagag  acttggttt  attcccagt  cccacacgg  ggctcttaa  3420
tccaatccc  ggggagatg  catcttctg  actctagaa  acaaggcat  cattggtgc  3480
gtcaaacat  caggcaaca  acacaaatt  agaaagcca  gtgctgtaa  aagttgcac  3540
tcccccaac  tacagtgct  cgcggtctg  gctggagtg  agctctctc  tgaacactc  3600
ggaaggctg  caggtgctg  gctggctag  gagacgggt  gggcccagc  ctggaagaa  3660
cgtcttcag  ctcagcaag  agacactcg  gttacctca  gctttgggg  ttcaggacc  3720
aggatgttt  gtacttatt  tgtgaggat  aataccatt  gcctgaatt  tcatttctg  3780
aagttttag  tataaaagc  ttttttctt  taagaattg  aatgtgctc  ccagcaaac  3840
cgtcttaac  agaataact  gtaactctg  ggacagtta  ccaaacctg  gccttgtct  3900
tcctgaggg  gtctgttac  ctaatactt  aacatgtac  ttgtggtat  ggctccttt  3960
actagtcat  acagcctta  atgttagtt  cactttgag  atttgctct  aggtgagtg  4020
ggtgtgtgg  tgtatgtat  aatgaaaca  ttggcagaa  ataagaaaa  catttttat  4080
aaattgtga  tttttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4128



<210> 1481
<211> 827
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1K9
<400> 1481

Met Arg Gln Arg Leu Leu Phe Leu Thr Thr Leu Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Glu Glu Pro Gly Ser Gly Ser His Leu Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Ile Arg Lys Arg Asp Leu Gln Ser Ala Thr 
     50                  55                  60
His Leu Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Leu Arg Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Glu Glu Ser Glu Tyr Ser Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Ser Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Gly Asp Asp Asp Val Thr Val Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asp Phe Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Asn Ala Asp Ser Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Ile Asp Arg Glu Pro Ser Glu Glu Phe 
         195                200                205
Val Arg Arg Val Lys Arg Arg Ala Glu Pro Asn Pro Leu Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Lys Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Val Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Arg His Phe Asn Met Ala Lys Ser Phe 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Leu Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Asn Pro Gly Val Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Pro Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asp 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Ala Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Lys Arg Glu Gln Glu Leu Glu Ser Cys Ala 
             580                585                590
Cys Ala Asp Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asn Leu Ser 
         595                600                605
Gly Pro Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His His Ser Asn Ile Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Ala Leu Gln Pro Ala Ala Met Met Pro Pro Val Ser 
             740                745                750
Ala Ala Pro Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp 
         755                760                765
Pro Ser Thr Asp Ser His Val Asp Asp Asp Gly Phe Glu Lys Asp Pro 
     770                775                780
Phe Pro Asn Ser Ser Ala Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp 
 785                790                795                800
His Pro Val Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg 
                 805                810                815
Gln Ser Arg Val Asp Ser Lys Glu Thr Glu Cys 
             820                825



<210> 1482
<211> 2877
<212> DNA
<213> Homo sapiens
<308> U69612
<400> 1482

ggaaaagag  attgagggg  taggccggg  ggatcccgt  ctcccccga  gtgagcagt  60
ttccgaaac  ccgtcaggc  aaggctgcc  agagaggtg  agtcggtag  ggggccggg  120
acatgaggc  gtctctcct  ttcctgacc  gcgtggttc  tttcgtgct  gcgccgcga  180
ctccggatg  cccgggctt  ggcccccac  agagactcg  gaagcttga  tctttgctc  240
cagactacg  tattctctc  ttatctaat  tccagcagc  ttcggtaag  aaaagagat  300
tacagactt  aacacatgt  gaaacacta  taacttttt  agctttgaa  aggcatttt  360
aattatacc  gacatcaag  actgaacgt  tttcacaaa  tttcaaggt  gtggtggtg  420
atggtaaaa  cgaaagcga  tacactgta  aatggcagg  cttcttcac  ggacacgtg  480
ttggtgagc  tgactctag  gttctagcc  acataagag  tgatgatgt  ataatcaga  540
tcaacacag  tggggccga  tataacata  agccacttt  gagatttgt  aatgatacc  600
aagacaaaa  aatgttagt  tataaatct  aagatatca  gaatgtttc  cgtttgcag  660
ctccaaaag  gtgtggtta  ttaaaagtg  ataatgaag  gttgctccc  aaagggtta  720
tagacagag  accacctga  gagcttgtt  atcgagtga  aagaagagc  gacccagat  780
ccatgaaga  cacgtgtaa  ttattggtg  tagcagatc  tcgcttcta  agatacatg  840
gcagagggg  agagagtac  actacaaat  acttaatag  gctaattga  agagttgat  900
acatctatc  gaacacttc  tgggataat  caggtttta  aggctatgg  atacagata  960
agcagattc  cattctcaa  tctccacaa  aggtaaaac  tggtgaaaa  cactacaac  1020
tggcaaaaa  ttacccaaa  gaagaaaag  atgcttggg  tgtgaagat  ttgctagag  1080
aatttagct  tgatatagc  gaggaagca  ctaaagttt  cttggcaca  cttttcaca  1140
accaagatt  tgatatggg  actcttgga  tagcttatg  tggctctcc  agagcaaac  1200
gccatggag  tgtttgtcc  aaggcttat  atagcccag  tgggaagaa  aatatctat  1260
tgaatagtg  tttgacgag  acaaagaat  atggtaaaa  catccttac  aaggaagct  1320
acctggtta  aactcatga  ttgggacat  attttggag  agaacatga  ccggatggt  1380
tagcagaat  tgccccgaa  gaggaccag  gagggaaat  tgtcatgta  cccatagct  1440
tgagtggcg  tcacgagaa  aataagatg  tttcaaact  cagtaaaca  tcaatctat  1500
agaccattg  aagtaaggc  caggagtgt  ttcaagaac  cagcaataa  gtttgtggg  1560
actcgaggg  ggatgaagg  gaagagtgt  atcctggca  catgtatct  aacaacgac  1620
cctgctgca  cagcgactg  acgttgaag  aaggtgtcc  gtgcagtga  aggaacagt  1680
cttgctgta  aaactgtca  tttgagact  cccagaaga  gtgccagga  gcgattaat  1740
ctacttgca  aggcgtgtc  tactgcaca  gtaatagca  tgagtgccc  cctccagga  1800
atgctgaag  tgacactgt  tgcttggat  ttggcaagt  taaggatgg  aaatgcatc  1860
ctttctgcg  gagggaaca  cagctggag  cctgtgcat  taatgaaac  gacaactcc  1920
gcaaggtgt  ctgcaggga  ctttccggc  gctgtgtgc  ctatgtcga  gctgaacaa  1980
agaacttat  tttgaggaa  ggaaagccc  gtacagtag  attttgtga  atgaatggc  2040
aatgtgaga  acgagtaca  gatgtaatt  aacgatttt  ggatttcat  gaccagctg  2100
gcatcaata  ttttggaaa  tttttagca  acaacatcg  tgggtctgt  ctggttttc  2160
ccttgatat  ttggattcc  ttcagcatt  ttgtccatt  tgtgtaacg  cgaaatgct  2220
agcagcatg  attctgcat  ggttcgcat  atcaaaccc  ttcctgcgc  ccagactcc  2280
ggccgcctg  agcctgccc  tgtgatccc  tcggcgcca  cagctccaa  actggacca  2340
cagagaatg  acaccatcc  ggaagaccc  agcacagac  cacatatgg  cgaggatgg  2400
tttgagaag  accccttcc  aaatagcag  acagctgcc  agtcatttg  ggatctcac  2460
gaccatccg  tcaccagaa  tgaaaaggc  gcctccttt  aactgcagc  tcagaatcg  2520
gttgacagc  aagaaacag  gtgctaatt  agttctcag  tcttctgac  taagtgtgc  2580
aaatatttt  atagatttg  cctacaatc  atcacagct  atattttgt  aagactggg  2640
agtgactta  cagatgctg  tcatgtgtt  gaacttcct  caggtaaac  gttcttgtg  2700
ggtttggcc  ttctccttt  gaaaaggta  ggtgaaggt  aatctagct  attttgagg  2760
tttcaggtt  tagttttta  aatatcttt  gacctgtgg  gcaaaagca  aaaatacag  2820
tggattggg  tatgagtat  tacgttttt  taaattaat  ttttatatt  ataacag  2877



<210> 1483
<211> 824
<212> PRT
<213> Homo sapiens
<308> P78536
<400> 1483

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
     50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
         195                200                205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
             580                585                590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
         595                600                605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
             740                745                750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
         755                760                765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
     770                775                780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
 785                790                795                800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                 805                810                815
Val Asp Ser Lys Glu Thr Glu Cys 
             820



<210> 1484
<211> 4128
<212> DNA
<213> Rattus norvegicus
<308> AJ012603
<400> 1484

ggttccggc  gtgggcagc  gggtggtcc  cgactgcgg  cggaagcag  ctgagcggc  60
ctcggcgag  gccgcctgt  cttccgggg  cttcagcct  gctcttgag  tttccctgt  120
ggcggcgcg  gagggaaaa  tttgcaggg  cgtgctggg  agatcacct  cgcttccca  180
tgtgagcag  ttctcgaac  ctctctcta  aaggttgcc  agagaggtg  tggacggga  240
catgaggca  cgtctcctc  tcctgacca  tttggtgcc  ttcgtcctg  caccccgac  300
tccggagga  ccaggctct  gctcccacc  gcgacttga  aagcttgat  ctttgctct  360
agactacga  atcctctct  tatctaata  ccagcagca  tccataagg  aaagggatc  420
acagtctgc  acacactta  aaacactac  aactttttc  gctttgaaa  ggcatttta  480
attatactt  acatcaagt  cagaacgct  ttcacagaa  ttgcgagtc  tggtggtgg  540
tgggaaaga  gaaagcgag  acagtgtga  gtggcagga  ttcttcagc  gacatgtgg  600
tggtgagcc  gactctagg  ttctagcgc  cataggaga  gatgatgtc  cagtaagaa  660
caacacaga  ggggcagaa  ataacatag  gccactttg  aggtttgtt  atgatacta  720
agataaaag  atgctggtg  ataagtctg  agatatcaa  gatttttca  gtttgcagt  780
tccaaaagt  tgtggttat  taaatgcag  tagtgaaga  ttgcttcca  aagggctca  840
agacagaga  ccatctgaa  agtttgtcc  tcgagtgaa  aggcgagct  aacctaacc  900
attgaagaa  acttgtaaa  tactggtgg  ggcagatca  cgattttat  agtacatgg  960
ccgaggaga  gagagcact  ctacaaatt  cttaataga  ttaattgac  gagttgatg  1020
catataccg  aacacctcg  gggacaatg  aggatttaa  ggttatgga  tacagatag  1080
acagattcg  attctcaag  ctccacaag  ggtaaaacc  ggtgaaaga  acttcaata  1140
ggcaaaaag  tttccaaat  aagaaaagg  tgcttggga  gtgaagatg  tgctggagc  1200
atttagcct  gatatagct  aagaggcct  taaagtctg  ctggctcat  ttttcacct  1260
ccaagattt  gatatggga  ctcttggat  agcttacgt  ggttctccc  gagcaaaca  1320
tcatggagg  gtttgtcca  aagcttatt  caacccagg  gtgaagaag  acatctatt  1380
gaatagtgg  ctgacaagt  caaaaaatt  tggtaaaac  atccttaca  aggaggctg  1440
cctggttac  actcatgaa  tgggacaca  ttttggagc  gaacatgat  ctgatgggc  1500
ggcagagtg  gccccaaat  aggaccaag  aggaaagta  gttatgtac  ccatagctg  1560
gagtggtga  catgagaat  ataagatgt  ttcaaactg  agtaaacag  ccatctaca  1620
gaccataga  agcaaggct  aagagtgct  ccaggagcg  agcaacaag  tgtgcggca  1680
ctccagggt  gacgaagga  aagagtgtg  cccgggcat  atgtacctg  acaacgaca  1740
ctgctgcaa  agtgactgc  cactgaagc  aggtgtgca  tgcagtgat  ggaatagtc  1800
ttgctgtaa  aattgtcag  ttgagacgg  ccagaagaa  tgccaggag  ctatcaatg  1860
tacttgcaa  ggagtgtct  actgcacag  gaatagcag  gagtgcccc  caccaggag  1920
tgctgaaga  gacactgtg  gcttggacc  gggcaagtg  aaggctggg  aatgcatcc  1980
tttctgcaa  agggagcag  agctggagt  ctgcgcatg  gctgacacc  acaactcgt  2040
caaggtatg  tgcaggaac  tttctggcc  atgtgtgcc  tacgtcgat  cagagcaaa  2100
gaacttatt  ttgaggaaa  ggaagccct  tacagtagg  ttttgtgac  tgaatggca  2160
atgtgagaa  cgggtacag  acgtaattg  gcggttttg  gatttcatt  accagctga  2220
catcaacac  tttgggaag  ttctggcag  caacatcgt  gggtctgtt  tggttttct  2280
cttgatatt  tggattcct  tcagcattc  tgtccactg  gtggataag  aactggaca  2340
gcagtatga  tccctgtct  tgtttcatc  cagtaacat  gagatgttg  gcagcatgg  2400
ctcagcatc  gttcgcatt  tcaagccgt  ccctgcacc  cagactcca  gtcgtctgc  2460
ggccctgca  ccggctgca  tgatgccgc  agtgtctgc  gctccaaaa  tggatcacc  2520
gaggatgga  accatccag  aagacccca  cacagattc  catgtggat  atgatggct  2580
tgagaagga  cccttcccc  acagcagtg  agccgccaa  tcctttgag  acctcacag  2640
ccacccagt  accaggagt  agaaggccg  ctccttcaa  ctgcagcgt  agagccgag  2700
tgatagcaa  gagacagag  gttagtggg  gcctgggcc  gctctgggg  acacagacc  2760
acagatgtt  cacagagct  acctgaatc  aaatagact  taatgatct  agaaacggg  2820
gcagcttag  agatgctgg  catgtgaca  gaccttcac  tgacatcct  tgtatgtag  2880
ccctttgaa  aggtgaggt  aatctggct  atttaaggc  ttcaggttt  ggggttttc  2940
tttgtaatc  aaaaatctc  tttgacctg  ggtgcagaa  cagaaaata  ggctggatc  3000
agttcctgg  gacagcact  attaagcct  cagtctgtt  ttctgtatg  tgtaaggtc  3060
tctcactac  gtgaagcac  tagcagtga  gataactgg  acacagact  tttgggggt  3120
ttggccttc  catgtgcgt  gtctccaaa  gccgtctgt  ttggcactg  actttgtgg  3180
tacagtcct  tccaagatg  agactagct  tggaacagt  tatacaaac  gccacatga  3240
cttcaagat  gcctattaa  tgcttagcc  caggttccc  ggacagttt  tccgttttg  3300
aaaaagtgt  ttcacgggt  tctaaacat  gtttgtctt  aaaaatact  ggctggaga  3360
ttggcccca  agttaagag  acttggttt  attcccagt  cccacacgg  ggctcttaa  3420
tccaatccc  ggggagatg  catcttctg  actctagaa  acaaggcat  cattggtgc  3480
gtcaaacat  caggcaaca  acacaaatt  agaaagcca  gtgctgtaa  aagttgcac  3540
tcccccaac  tacagtgct  cgcggtctg  gctggagtg  agctctctc  tgaacactc  3600
ggaaggctg  caggtgctg  gctggctag  gagacgggt  gggcccagc  ctggaagaa  3660
cgtcttcag  ctcagcaag  agacactcg  gttacctca  gctttgggg  ttcaggacc  3720
aggatgttt  gtacttatt  tgtgaggat  aataccatt  gcctgaatt  tcatttctg  3780
aagttttag  tataaaagc  ttttttctt  taagaattg  aatgtgctc  ccagcaaac  3840
cgtcttaac  agaataact  gtaactctg  ggacagtta  ccaaacctg  gccttgtct  3900
tcctgaggg  gtctgttac  ctaatactt  aacatgtac  ttgtggtat  ggctccttt  3960
actagtcat  acagcctta  atgttagtt  cactttgag  atttgctct  aggtgagtg  4020
ggtgtgtgg  tgtatgtat  aatgaaaca  ttggcagaa  ataagaaaa  catttttat  4080
aaattgtga  tttttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4128



<210> 1485
<211> 827
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1K9
<400> 1485

Met Arg Gln Arg Leu Leu Phe Leu Thr Thr Leu Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Glu Glu Pro Gly Ser Gly Ser His Leu Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Ile Arg Lys Arg Asp Leu Gln Ser Ala Thr 
     50                  55                  60
His Leu Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Leu Arg Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Glu Glu Ser Glu Tyr Ser Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Ser Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Gly Asp Asp Asp Val Thr Val Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asp Phe Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Asn Ala Asp Ser Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Ile Asp Arg Glu Pro Ser Glu Glu Phe 
         195                200                205
Val Arg Arg Val Lys Arg Arg Ala Glu Pro Asn Pro Leu Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Lys Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Val Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Arg His Phe Asn Met Ala Lys Ser Phe 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Leu Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Asn Pro Gly Val Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Pro Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asp 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Ala Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Lys Arg Glu Gln Glu Leu Glu Ser Cys Ala 
             580                585                590
Cys Ala Asp Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asn Leu Ser 
         595                600                605
Gly Pro Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His His Ser Asn Ile Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Ala Leu Gln Pro Ala Ala Met Met Pro Pro Val Ser 
             740                745                750
Ala Ala Pro Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp 
         755                760                765
Pro Ser Thr Asp Ser His Val Asp Asp Asp Gly Phe Glu Lys Asp Pro 
     770                775                780
Phe Pro Asn Ser Ser Ala Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp 
 785                790                795                800
His Pro Val Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg 
                 805                810                815
Gln Ser Arg Val Asp Ser Lys Glu Thr Glu Cys 
             820                825



<210> 1486
<211> 2877
<212> DNA
<213> Homo sapiens
<308> U69612
<400> 1486

ggaaaagag  attgagggg  taggccggg  ggatcccgt  ctcccccga  gtgagcagt  60
ttccgaaac  ccgtcaggc  aaggctgcc  agagaggtg  agtcggtag  ggggccggg  120
acatgaggc  gtctctcct  ttcctgacc  gcgtggttc  tttcgtgct  gcgccgcga  180
ctccggatg  cccgggctt  ggcccccac  agagactcg  gaagcttga  tctttgctc  240
cagactacg  tattctctc  ttatctaat  tccagcagc  ttcggtaag  aaaagagat  300
tacagactt  aacacatgt  gaaacacta  taacttttt  agctttgaa  aggcatttt  360
aattatacc  gacatcaag  actgaacgt  tttcacaaa  tttcaaggt  gtggtggtg  420
atggtaaaa  cgaaagcga  tacactgta  aatggcagg  cttcttcac  ggacacgtg  480
ttggtgagc  tgactctag  gttctagcc  acataagag  tgatgatgt  ataatcaga  540
tcaacacag  tggggccga  tataacata  agccacttt  gagatttgt  aatgatacc  600
aagacaaaa  aatgttagt  tataaatct  aagatatca  gaatgtttc  cgtttgcag  660
ctccaaaag  gtgtggtta  ttaaaagtg  ataatgaag  gttgctccc  aaagggtta  720
tagacagag  accacctga  gagcttgtt  atcgagtga  aagaagagc  gacccagat  780
ccatgaaga  cacgtgtaa  ttattggtg  tagcagatc  tcgcttcta  agatacatg  840
gcagagggg  agagagtac  actacaaat  acttaatag  gctaattga  agagttgat  900
acatctatc  gaacacttc  tgggataat  caggtttta  aggctatgg  atacagata  960
agcagattc  cattctcaa  tctccacaa  aggtaaaac  tggtgaaaa  cactacaac  1020
tggcaaaaa  ttacccaaa  gaagaaaag  atgcttggg  tgtgaagat  ttgctagag  1080
aatttagct  tgatatagc  gaggaagca  ctaaagttt  cttggcaca  cttttcaca  1140
accaagatt  tgatatggg  actcttgga  tagcttatg  tggctctcc  agagcaaac  1200
gccatggag  tgtttgtcc  aaggcttat  atagcccag  tgggaagaa  aatatctat  1260
tgaatagtg  tttgacgag  acaaagaat  atggtaaaa  catccttac  aaggaagct  1320
acctggtta  aactcatga  ttgggacat  attttggag  agaacatga  ccggatggt  1380
tagcagaat  tgccccgaa  gaggaccag  gagggaaat  tgtcatgta  cccatagct  1440
tgagtggcg  tcacgagaa  aataagatg  tttcaaact  cagtaaaca  tcaatctat  1500
agaccattg  aagtaaggc  caggagtgt  ttcaagaac  cagcaataa  gtttgtggg  1560
actcgaggg  ggatgaagg  gaagagtgt  atcctggca  catgtatct  aacaacgac  1620
cctgctgca  cagcgactg  acgttgaag  aaggtgtcc  gtgcagtga  aggaacagt  1680
cttgctgta  aaactgtca  tttgagact  cccagaaga  gtgccagga  gcgattaat  1740
ctacttgca  aggcgtgtc  tactgcaca  gtaatagca  tgagtgccc  cctccagga  1800
atgctgaag  tgacactgt  tgcttggat  ttggcaagt  taaggatgg  aaatgcatc  1860
ctttctgcg  gagggaaca  cagctggag  cctgtgcat  taatgaaac  gacaactcc  1920
gcaaggtgt  ctgcaggga  ctttccggc  gctgtgtgc  ctatgtcga  gctgaacaa  1980
agaacttat  tttgaggaa  ggaaagccc  gtacagtag  attttgtga  atgaatggc  2040
aatgtgaga  acgagtaca  gatgtaatt  aacgatttt  ggatttcat  gaccagctg  2100
gcatcaata  ttttggaaa  tttttagca  acaacatcg  tgggtctgt  ctggttttc  2160
ccttgatat  ttggattcc  ttcagcatt  ttgtccatt  tgtgtaacg  cgaaatgct  2220
agcagcatg  attctgcat  ggttcgcat  atcaaaccc  ttcctgcgc  ccagactcc  2280
ggccgcctg  agcctgccc  tgtgatccc  tcggcgcca  cagctccaa  actggacca  2340
cagagaatg  acaccatcc  ggaagaccc  agcacagac  cacatatgg  cgaggatgg  2400
tttgagaag  accccttcc  aaatagcag  acagctgcc  agtcatttg  ggatctcac  2460
gaccatccg  tcaccagaa  tgaaaaggc  gcctccttt  aactgcagc  tcagaatcg  2520
gttgacagc  aagaaacag  gtgctaatt  agttctcag  tcttctgac  taagtgtgc  2580
aaatatttt  atagatttg  cctacaatc  atcacagct  atattttgt  aagactggg  2640
agtgactta  cagatgctg  tcatgtgtt  gaacttcct  caggtaaac  gttcttgtg  2700
ggtttggcc  ttctccttt  gaaaaggta  ggtgaaggt  aatctagct  attttgagg  2760
tttcaggtt  tagttttta  aatatcttt  gacctgtgg  gcaaaagca  aaaatacag  2820
tggattggg  tatgagtat  tacgttttt  taaattaat  ttttatatt  ataacag  2877



<210> 1487
<211> 824
<212> PRT
<213> Homo sapiens
<308> P78536
<400> 1487

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
     50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
         195                200                205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
             580                585                590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
         595                600                605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
             740                745                750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
         755                760                765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
     770                775                780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
 785                790                795                800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                 805                810                815
Val Asp Ser Lys Glu Thr Glu Cys 
             820



<210> 1488
<211> 4128
<212> DNA
<213> Rattus norvegicus
<308> AJ012603
<400> 1488

ggttccggc  gtgggcagc  gggtggtcc  cgactgcgg  cggaagcag  ctgagcggc  60
ctcggcgag  gccgcctgt  cttccgggg  cttcagcct  gctcttgag  tttccctgt  120
ggcggcgcg  gagggaaaa  tttgcaggg  cgtgctggg  agatcacct  cgcttccca  180
tgtgagcag  ttctcgaac  ctctctcta  aaggttgcc  agagaggtg  tggacggga  240
catgaggca  cgtctcctc  tcctgacca  tttggtgcc  ttcgtcctg  caccccgac  300
tccggagga  ccaggctct  gctcccacc  gcgacttga  aagcttgat  ctttgctct  360
agactacga  atcctctct  tatctaata  ccagcagca  tccataagg  aaagggatc  420
acagtctgc  acacactta  aaacactac  aactttttc  gctttgaaa  ggcatttta  480
attatactt  acatcaagt  cagaacgct  ttcacagaa  ttgcgagtc  tggtggtgg  540
tgggaaaga  gaaagcgag  acagtgtga  gtggcagga  ttcttcagc  gacatgtgg  600
tggtgagcc  gactctagg  ttctagcgc  cataggaga  gatgatgtc  cagtaagaa  660
caacacaga  ggggcagaa  ataacatag  gccactttg  aggtttgtt  atgatacta  720
agataaaag  atgctggtg  ataagtctg  agatatcaa  gatttttca  gtttgcagt  780
tccaaaagt  tgtggttat  taaatgcag  tagtgaaga  ttgcttcca  aagggctca  840
agacagaga  ccatctgaa  agtttgtcc  tcgagtgaa  aggcgagct  aacctaacc  900
attgaagaa  acttgtaaa  tactggtgg  ggcagatca  cgattttat  agtacatgg  960
ccgaggaga  gagagcact  ctacaaatt  cttaataga  ttaattgac  gagttgatg  1020
catataccg  aacacctcg  gggacaatg  aggatttaa  ggttatgga  tacagatag  1080
acagattcg  attctcaag  ctccacaag  ggtaaaacc  ggtgaaaga  acttcaata  1140
ggcaaaaag  tttccaaat  aagaaaagg  tgcttggga  gtgaagatg  tgctggagc  1200
atttagcct  gatatagct  aagaggcct  taaagtctg  ctggctcat  ttttcacct  1260
ccaagattt  gatatggga  ctcttggat  agcttacgt  ggttctccc  gagcaaaca  1320
tcatggagg  gtttgtcca  aagcttatt  caacccagg  gtgaagaag  acatctatt  1380
gaatagtgg  ctgacaagt  caaaaaatt  tggtaaaac  atccttaca  aggaggctg  1440
cctggttac  actcatgaa  tgggacaca  ttttggagc  gaacatgat  ctgatgggc  1500
ggcagagtg  gccccaaat  aggaccaag  aggaaagta  gttatgtac  ccatagctg  1560
gagtggtga  catgagaat  ataagatgt  ttcaaactg  agtaaacag  ccatctaca  1620
gaccataga  agcaaggct  aagagtgct  ccaggagcg  agcaacaag  tgtgcggca  1680
ctccagggt  gacgaagga  aagagtgtg  cccgggcat  atgtacctg  acaacgaca  1740
ctgctgcaa  agtgactgc  cactgaagc  aggtgtgca  tgcagtgat  ggaatagtc  1800
ttgctgtaa  aattgtcag  ttgagacgg  ccagaagaa  tgccaggag  ctatcaatg  1860
tacttgcaa  ggagtgtct  actgcacag  gaatagcag  gagtgcccc  caccaggag  1920
tgctgaaga  gacactgtg  gcttggacc  gggcaagtg  aaggctggg  aatgcatcc  1980
tttctgcaa  agggagcag  agctggagt  ctgcgcatg  gctgacacc  acaactcgt  2040
caaggtatg  tgcaggaac  tttctggcc  atgtgtgcc  tacgtcgat  cagagcaaa  2100
gaacttatt  ttgaggaaa  ggaagccct  tacagtagg  ttttgtgac  tgaatggca  2160
atgtgagaa  cgggtacag  acgtaattg  gcggttttg  gatttcatt  accagctga  2220
catcaacac  tttgggaag  ttctggcag  caacatcgt  gggtctgtt  tggttttct  2280
cttgatatt  tggattcct  tcagcattc  tgtccactg  gtggataag  aactggaca  2340
gcagtatga  tccctgtct  tgtttcatc  cagtaacat  gagatgttg  gcagcatgg  2400
ctcagcatc  gttcgcatt  tcaagccgt  ccctgcacc  cagactcca  gtcgtctgc  2460
ggccctgca  ccggctgca  tgatgccgc  agtgtctgc  gctccaaaa  tggatcacc  2520
gaggatgga  accatccag  aagacccca  cacagattc  catgtggat  atgatggct  2580
tgagaagga  cccttcccc  acagcagtg  agccgccaa  tcctttgag  acctcacag  2640
ccacccagt  accaggagt  agaaggccg  ctccttcaa  ctgcagcgt  agagccgag  2700
tgatagcaa  gagacagag  gttagtggg  gcctgggcc  gctctgggg  acacagacc  2760
acagatgtt  cacagagct  acctgaatc  aaatagact  taatgatct  agaaacggg  2820
gcagcttag  agatgctgg  catgtgaca  gaccttcac  tgacatcct  tgtatgtag  2880
ccctttgaa  aggtgaggt  aatctggct  atttaaggc  ttcaggttt  ggggttttc  2940
tttgtaatc  aaaaatctc  tttgacctg  ggtgcagaa  cagaaaata  ggctggatc  3000
agttcctgg  gacagcact  attaagcct  cagtctgtt  ttctgtatg  tgtaaggtc  3060
tctcactac  gtgaagcac  tagcagtga  gataactgg  acacagact  tttgggggt  3120
ttggccttc  catgtgcgt  gtctccaaa  gccgtctgt  ttggcactg  actttgtgg  3180
tacagtcct  tccaagatg  agactagct  tggaacagt  tatacaaac  gccacatga  3240
cttcaagat  gcctattaa  tgcttagcc  caggttccc  ggacagttt  tccgttttg  3300
aaaaagtgt  ttcacgggt  tctaaacat  gtttgtctt  aaaaatact  ggctggaga  3360
ttggcccca  agttaagag  acttggttt  attcccagt  cccacacgg  ggctcttaa  3420
tccaatccc  ggggagatg  catcttctg  actctagaa  acaaggcat  cattggtgc  3480
gtcaaacat  caggcaaca  acacaaatt  agaaagcca  gtgctgtaa  aagttgcac  3540
tcccccaac  tacagtgct  cgcggtctg  gctggagtg  agctctctc  tgaacactc  3600
ggaaggctg  caggtgctg  gctggctag  gagacgggt  gggcccagc  ctggaagaa  3660
cgtcttcag  ctcagcaag  agacactcg  gttacctca  gctttgggg  ttcaggacc  3720
aggatgttt  gtacttatt  tgtgaggat  aataccatt  gcctgaatt  tcatttctg  3780
aagttttag  tataaaagc  ttttttctt  taagaattg  aatgtgctc  ccagcaaac  3840
cgtcttaac  agaataact  gtaactctg  ggacagtta  ccaaacctg  gccttgtct  3900
tcctgaggg  gtctgttac  ctaatactt  aacatgtac  ttgtggtat  ggctccttt  3960
actagtcat  acagcctta  atgttagtt  cactttgag  atttgctct  aggtgagtg  4020
ggtgtgtgg  tgtatgtat  aatgaaaca  ttggcagaa  ataagaaaa  catttttat  4080
aaattgtga  tttttaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4128



<210> 1489
<211> 827
<212> PRT
<213> Rattus norvegicus
<308> Q9Z1K9
<400> 1489

Met Arg Gln Arg Leu Leu Phe Leu Thr Thr Leu Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Glu Glu Pro Gly Ser Gly Ser His Leu Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Ile Arg Lys Arg Asp Leu Gln Ser Ala Thr 
     50                  55                  60
His Leu Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Leu Arg Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Glu Glu Ser Glu Tyr Ser Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Ser Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Gly Asp Asp Asp Val Thr Val Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asp Phe Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Asn Ala Asp Ser Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Ile Asp Arg Glu Pro Ser Glu Glu Phe 
         195                200                205
Val Arg Arg Val Lys Arg Arg Ala Glu Pro Asn Pro Leu Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Lys Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Val Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Arg His Phe Asn Met Ala Lys Ser Phe 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Leu Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Asn Pro Gly Val Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Pro Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asp 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Ala Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Lys Arg Glu Gln Glu Leu Glu Ser Cys Ala 
             580                585                590
Cys Ala Asp Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asn Leu Ser 
         595                600                605
Gly Pro Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His His Ser Asn Ile Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Ala Leu Gln Pro Ala Ala Met Met Pro Pro Val Ser 
             740                745                750
Ala Ala Pro Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp 
         755                760                765
Pro Ser Thr Asp Ser His Val Asp Asp Asp Gly Phe Glu Lys Asp Pro 
     770                775                780
Phe Pro Asn Ser Ser Ala Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp 
 785                790                795                800
His Pro Val Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg 
                 805                810                815
Gln Ser Arg Val Asp Ser Lys Glu Thr Glu Cys 
             820                825



<210> 1490
<211> 2877
<212> DNA
<213> Homo sapiens
<308> U69612
<400> 1490

ggaaaagag  attgagggg  taggccggg  ggatcccgt  ctcccccga  gtgagcagt  60
ttccgaaac  ccgtcaggc  aaggctgcc  agagaggtg  agtcggtag  ggggccggg  120
acatgaggc  gtctctcct  ttcctgacc  gcgtggttc  tttcgtgct  gcgccgcga  180
ctccggatg  cccgggctt  ggcccccac  agagactcg  gaagcttga  tctttgctc  240
cagactacg  tattctctc  ttatctaat  tccagcagc  ttcggtaag  aaaagagat  300
tacagactt  aacacatgt  gaaacacta  taacttttt  agctttgaa  aggcatttt  360
aattatacc  gacatcaag  actgaacgt  tttcacaaa  tttcaaggt  gtggtggtg  420
atggtaaaa  cgaaagcga  tacactgta  aatggcagg  cttcttcac  ggacacgtg  480
ttggtgagc  tgactctag  gttctagcc  acataagag  tgatgatgt  ataatcaga  540
tcaacacag  tggggccga  tataacata  agccacttt  gagatttgt  aatgatacc  600
aagacaaaa  aatgttagt  tataaatct  aagatatca  gaatgtttc  cgtttgcag  660
ctccaaaag  gtgtggtta  ttaaaagtg  ataatgaag  gttgctccc  aaagggtta  720
tagacagag  accacctga  gagcttgtt  atcgagtga  aagaagagc  gacccagat  780
ccatgaaga  cacgtgtaa  ttattggtg  tagcagatc  tcgcttcta  agatacatg  840
gcagagggg  agagagtac  actacaaat  acttaatag  gctaattga  agagttgat  900
acatctatc  gaacacttc  tgggataat  caggtttta  aggctatgg  atacagata  960
agcagattc  cattctcaa  tctccacaa  aggtaaaac  tggtgaaaa  cactacaac  1020
tggcaaaaa  ttacccaaa  gaagaaaag  atgcttggg  tgtgaagat  ttgctagag  1080
aatttagct  tgatatagc  gaggaagca  ctaaagttt  cttggcaca  cttttcaca  1140
accaagatt  tgatatggg  actcttgga  tagcttatg  tggctctcc  agagcaaac  1200
gccatggag  tgtttgtcc  aaggcttat  atagcccag  tgggaagaa  aatatctat  1260
tgaatagtg  tttgacgag  acaaagaat  atggtaaaa  catccttac  aaggaagct  1320
acctggtta  aactcatga  ttgggacat  attttggag  agaacatga  ccggatggt  1380
tagcagaat  tgccccgaa  gaggaccag  gagggaaat  tgtcatgta  cccatagct  1440
tgagtggcg  tcacgagaa  aataagatg  tttcaaact  cagtaaaca  tcaatctat  1500
agaccattg  aagtaaggc  caggagtgt  ttcaagaac  cagcaataa  gtttgtggg  1560
actcgaggg  ggatgaagg  gaagagtgt  atcctggca  catgtatct  aacaacgac  1620
cctgctgca  cagcgactg  acgttgaag  aaggtgtcc  gtgcagtga  aggaacagt  1680
cttgctgta  aaactgtca  tttgagact  cccagaaga  gtgccagga  gcgattaat  1740
ctacttgca  aggcgtgtc  tactgcaca  gtaatagca  tgagtgccc  cctccagga  1800
atgctgaag  tgacactgt  tgcttggat  ttggcaagt  taaggatgg  aaatgcatc  1860
ctttctgcg  gagggaaca  cagctggag  cctgtgcat  taatgaaac  gacaactcc  1920
gcaaggtgt  ctgcaggga  ctttccggc  gctgtgtgc  ctatgtcga  gctgaacaa  1980
agaacttat  tttgaggaa  ggaaagccc  gtacagtag  attttgtga  atgaatggc  2040
aatgtgaga  acgagtaca  gatgtaatt  aacgatttt  ggatttcat  gaccagctg  2100
gcatcaata  ttttggaaa  tttttagca  acaacatcg  tgggtctgt  ctggttttc  2160
ccttgatat  ttggattcc  ttcagcatt  ttgtccatt  tgtgtaacg  cgaaatgct  2220
agcagcatg  attctgcat  ggttcgcat  atcaaaccc  ttcctgcgc  ccagactcc  2280
ggccgcctg  agcctgccc  tgtgatccc  tcggcgcca  cagctccaa  actggacca  2340
cagagaatg  acaccatcc  ggaagaccc  agcacagac  cacatatgg  cgaggatgg  2400
tttgagaag  accccttcc  aaatagcag  acagctgcc  agtcatttg  ggatctcac  2460
gaccatccg  tcaccagaa  tgaaaaggc  gcctccttt  aactgcagc  tcagaatcg  2520
gttgacagc  aagaaacag  gtgctaatt  agttctcag  tcttctgac  taagtgtgc  2580
aaatatttt  atagatttg  cctacaatc  atcacagct  atattttgt  aagactggg  2640
agtgactta  cagatgctg  tcatgtgtt  gaacttcct  caggtaaac  gttcttgtg  2700
ggtttggcc  ttctccttt  gaaaaggta  ggtgaaggt  aatctagct  attttgagg  2760
tttcaggtt  tagttttta  aatatcttt  gacctgtgg  gcaaaagca  aaaatacag  2820
tggattggg  tatgagtat  tacgttttt  taaattaat  ttttatatt  ataacag  2877



<210> 1491
<211> 824
<212> PRT
<213> Homo sapiens
<308> P78536
<400> 1491

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
  1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
             20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
         35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
     50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
 65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                 85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
             100                105                110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
         115                120                125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
     130                135                140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
 145                150                155                160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                 165                170                175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
             180                185                190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
         195                200                205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
     210                215                220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
 225                230                235                240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                 245                250                255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
             260                265                270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
         275                280                285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
     290                295                300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
 305                310                315                320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                 325                330                335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
             340                345                350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
         355                360                365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
     370                375                380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
 385                390                395                400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                 405                410                415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
             420                425                430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
         435                440                445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
     450                455                460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
 465                470                475                480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                 485                490                495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
             500                505                510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
         515                520                525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
     530                535                540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
 545                550                555                560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                 565                570                575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
             580                585                590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
         595                600                605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
     610                615                620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
 625                630                635                640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                 645                650                655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
             660                665                670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
         675                680                685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
     690                695                700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
 705                710                715                720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                 725                730                735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
             740                745                750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
         755                760                765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
     770                775                780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
 785                790                795                800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                 805                810                815
Val Asp Ser Lys Glu Thr Glu Cys 
             820



<210> 1492
<211> 1312
<212> DNA
<213> Rattus norvegicus
<308> AJ132230
<400> 1492

ggagctgcc  caggacaga  acctcccaa  acagcagtc  ccatcaaaa  cacaggtga  60
gctgtgagc  ctttgcttt  ctatccgga  cacagctgg  tttgacctc  tgtactgtg  120
caacgtcag  tcactgtgg  tggcgtccg  ggtcttgtt  gagctccag  cctctaacc  180
aagcctgca  gcccctgcc  acattacct  ctgcgagag  gccctagaa  actgggacc  240
gctgtatcg  gtgctgcca  ggttcgtca  cactatctg  ttctttggc  tcttgggga  300
ccttttagt  ttgtccttc  tccttttgc  ttggcgaca  tggtggtgg  agcaacgac  360
gaggcagca  cgcttaacc  tagcggaaa  ctacctggc  aacttggcg  cttccgatc  420
ggtgtttgt  ctgggcctg  ccttctggg  agagaacat  gggaaccgt  tcaactggc  480
cttcggaac  gacctctgc  gggtggtca  cggggtcat  aaggccaac  tgtttgtca  540
catcttcct  gtggtggct  tcagtcagg  ccgctacag  ctcctggta  accccatga  600
cagctgggg  taccggcgg  gacggcaag  ccaagctac  tgcctgctc  tctgggtag  660
cgggggtct  ttgagcatc  ccacattcc  tctacgctc  gttaaagtc  tccccgatc  720
gaacgtctc  gcctgcatc  tgcttttcc  ccacgaggc  tggcacttt  caaggatgg  780
ggagttgaa  gttttgggt  tcctcctcc  cgtgactgc  atcatcttc  tcaactatc  840
catcctggc  tccctgaga  gacagaagg  ggccagcag  actaggtgt  ggggtccca  900
gggcagcaa  acgacgggg  tgatcctca  actggtagc  tccttcctg  tctgctggt  960
cccttacca  ttcttcgct  tcctggatt  cctggtcca  gtaagagtg  tccaggact  1020
ctcctggaa  gagatcaca  acctgggcc  gcagctcgc  aacttcttt  cctttgtca  1080
cagctgctt  aacccactg  tttatgtct  cgcaggccg  ctccttaag  ccagggttc  1140
ggggacttt  taaatgatg  aaccgagaa  cctcatgcc  atgtggccc  acaggaagg  1200
actcttcca  ttatcctgc  ggaattcaa  cagcaggga  ccaagaagc  tggcttctt  1260
accaaccat  tctggtatc  taaagacca  ctggtcagc  gacccacag  cc  1312



<210> 1493
<211> 337
<212> PRT
<213> Rattus norvegicus
<308> P97583
<400> 1493

Met Ala Ser Glu Val Leu Leu Glu Leu Gln Pro Ser Asn Arg Ser Leu 
  1               5                  10                  15
Gln Ala Pro Ala Asn Ile Thr Ser Cys Glu Ser Ala Leu Glu Asp Trp 
             20                  25                  30
Asp Leu Leu Tyr Arg Val Leu Pro Gly Phe Val Ile Thr Ile Cys Phe 
         35                  40                  45
Phe Gly Leu Leu Gly Asn Leu Leu Val Leu Ser Phe Phe Leu Leu Pro 
     50                  55                  60
Trp Arg Gln Trp Trp Trp Gln Gln Arg Gln Arg Gln Gln Arg Leu Thr 
 65                  70                  75                  80
Ile Ala Glu Ile Tyr Leu Ala Asn Leu Ala Ala Ser Asp Leu Val Phe 
                 85                  90                  95
Val Leu Gly Leu Pro Phe Trp Ala Glu Asn Ile Gly Asn Arg Phe Asn 
             100                105                110
Trp Pro Phe Gly Thr Asp Leu Cys Arg Val Val Ser Gly Val Ile Lys 
         115                120                125
Ala Asn Leu Phe Val Ser Ile Phe Leu Val Val Ala Ile Ser Gln Asp 
     130                135                140
Arg Tyr Arg Leu Leu Val Tyr Pro Met Thr Ser Trp Gly Tyr Arg Arg 
 145                150                155                160
Arg Arg Gln Ala Gln Ala Thr Cys Leu Leu Ile Trp Val Ala Gly Gly 
                 165                170                175
Leu Leu Ser Ile Pro Thr Phe Leu Leu Arg Ser Val Lys Val Val Pro 
             180                185                190
Asp Leu Asn Val Ser Ala Cys Ile Leu Leu Phe Pro His Glu Ala Trp 
         195                200                205
His Phe Ala Arg Met Val Glu Leu Asn Val Leu Gly Phe Leu Leu Pro 
     210                215                220
Val Thr Ala Ile Ile Phe Phe Asn Tyr His Ile Leu Ala Ser Leu Arg 
 225                230                235                240
Gly Gln Lys Glu Ala Ser Arg Thr Arg Cys Gly Gly Pro Lys Gly Ser 
                 245                250                255
Lys Thr Thr Gly Leu Ile Leu Thr Leu Val Ala Ser Phe Leu Val Cys 
             260                265                270
Trp Cys Pro Tyr His Phe Phe Ala Phe Leu Asp Phe Leu Val Gln Val 
         275                280                285
Arg Val Ile Gln Asp Cys Ser Trp Lys Glu Ile Thr Asp Leu Gly Leu 
     290                295                300
Gln Leu Ala Asn Phe Phe Ala Phe Val Asn Ser Cys Leu Asn Pro Leu 
 305                310                315                320
Ile Tyr Val Phe Ala Gly Arg Leu Leu Lys Thr Arg Val Leu Gly Thr 
                 325                330                335
Leu 
             340



<210> 1494
<211> 1302
<212> DNA
<213> Homo sapiens
<308> AJ238044
<400> 1494

aaaactcct  caaaagcag  tctcactat  agaaaaccc  actacagtt  tgaacgcct  60
cattttctg  ctgaggtct  agtccgtcg  cccagactg  agtgcagtg  cacaatcat  120
gctcgctgc  gcctcgacc  tccaggctt  aacgattct  ccacctcag  ctctcgagt  180
gctgggacc  caggtcact  tgcatggca  catcctggc  ccctctaga  ctccaatcc  240
ccaaccaga  ccagctctt  cctcaaaat  ctacggcct  tgacaatgc  ccagaagcc  300
gggacctgc  gcacagagt  ctgccgaca  ttatcatct  catctgttt  ttcggcctc  360
tagggaacc  ttttgtcct  ttggtcttc  tcctgcccc  gcggcaact  aacgtggca  420
aaatctacc  ggccaacct  gcagcctct  atctggtgt  tgtcttggg  ttgcccttc  480
gggcagaga  tatctggaa  cagtttaac  ggcctttcg  agccctcct  tgccgtgtc  540
tcaacgggg  catcaaggc  aatttgttc  tcagcatct  cctggtggt  gccatcagc  600
aggaccgct  ccgcgtgct  gtgcaccct  tggccagcc  gaggcagca  cggcggagg  660
aggcccggg  cacctgcgt  ctcatctgg  ttgtggggg  cctcttgag  atccccaca  720
tcctgctgc  atccatcca  gccgtccca  atctgaaca  caccgcctg  atcctgctc  780
tcccccatg  ggcctggca  tttgcaagg  ttgtggagt  aaatattct  ggtttcctc  840
taccactgg  tgcgatcgt  ttcttcaac  accacatcc  ggcctccct  cgaacgcgg  900
aggaggtca  caggacaag  tgcgggggc  gcaaggata  caagaccac  gcgctgatc  960
tcacgctcg  ggttgcctt  ctggtctgc  gggcccctt  ccacttctt  gccttcctg  1020
aattcttat  ccaggtgca  gcagtccga  gctgctttt  ggaggactt  attgacctg  1080
gcctgcaat  ggccaactt  tttgccttc  ctaacagct  cctgaatcc  gtaatttat  1140
tctttgtgg  ccggctctt  aggaccaag  tctgggaac  ttataaaca  tgcacccct  1200
aaagtcttg  tccaatatc  tcatcccat  ggaaagaaa  cttccaact  ttctggcgg  1260
attaaaaca  cattgaacc  agaaaaaaa  aaaaaaaaa  aa  1302



<210> 1495
<211> 353
<212> PRT
<213> Homo sapiens
<308> P46663
<400> 1495

Met Ala Ser Ser Trp Pro Pro Leu Glu Leu Gln Ser Ser Asn Gln Ser 
  1               5                  10                  15
Gln Leu Phe Pro Gln Asn Ala Thr Ala Cys Asp Asn Ala Pro Glu Ala 
             20                  25                  30
Trp Asp Leu Leu His Arg Val Leu Pro Thr Phe Ile Ile Ser Ile Cys 
         35                  40                  45
Phe Phe Gly Leu Leu Gly Asn Leu Phe Val Leu Leu Val Phe Leu Leu 
     50                  55                  60
Pro Arg Arg Gln Leu Asn Val Ala Glu Ile Tyr Leu Ala Asn Leu Ala 
 65                  70                  75                  80
Ala Ser Asp Leu Val Phe Val Leu Gly Leu Pro Phe Trp Ala Glu Asn 
                 85                  90                  95
Ile Trp Asn Gln Phe Asn Trp Pro Phe Gly Ala Leu Leu Cys Arg Val 
             100                105                110
Ile Asn Gly Val Ile Lys Ala Asn Leu Phe Ile Ser Ile Phe Leu Val 
         115                120                125
Val Ala Ile Ser Gln Asp Arg Tyr Arg Val Leu Val His Pro Met Ala 
     130                135                140
Ser Gly Arg Gln Gln Arg Arg Arg Gln Ala Arg Val Thr Cys Val Leu 
 145                150                155                160
Ile Trp Val Val Gly Gly Leu Leu Ser Ile Pro Thr Phe Leu Leu Arg 
                 165                170                175
Ser Ile Gln Ala Val Pro Asp Leu Asn Ile Thr Ala Cys Ile Leu Leu 
             180                185                190
Leu Pro His Glu Ala Trp His Phe Ala Arg Ile Val Glu Leu Asn Ile 
         195                200                205
Leu Gly Phe Leu Leu Pro Leu Ala Ala Ile Val Phe Phe Asn Tyr His 
     210                215                220
Ile Leu Ala Ser Leu Arg Thr Arg Glu Glu Val Ser Arg Thr Arg Val 
 225                230                235                240
Arg Gly Pro Lys Asp Ser Lys Thr Thr Ala Leu Ile Leu Thr Leu Val 
                 245                250                255
Val Ala Phe Leu Val Cys Trp Ala Pro Tyr His Phe Phe Ala Phe Leu 
             260                265                270
Glu Phe Leu Phe Gln Val Gln Ala Val Arg Gly Cys Phe Trp Glu Asp 
         275                280                285
Phe Ile Asp Leu Gly Leu Gln Leu Ala Asn Phe Phe Ala Phe Thr Asn 
     290                295                300
Ser Ser Leu Asn Pro Val Ile Tyr Val Phe Val Gly Arg Leu Phe Arg 
 305                310                315                320
Thr Lys Val Trp Glu Leu Tyr Lys Gln Cys Thr Pro Lys Ser Leu Ala 
                 325                330                335
Pro Ile Ser Ser Ser His Arg Lys Glu Ile Phe Gln Leu Phe Trp Arg 
             340                345                350
Asn 
         355



<210> 1496
<211> 1312
<212> DNA
<213> Rattus norvegicus
<308> AJ132230
<400> 1496

ggagctgcc  caggacaga  acctcccaa  acagcagtc  ccatcaaaa  cacaggtga  60
gctgtgagc  ctttgcttt  ctatccgga  cacagctgg  tttgacctc  tgtactgtg  120
caacgtcag  tcactgtgg  tggcgtccg  ggtcttgtt  gagctccag  cctctaacc  180
aagcctgca  gcccctgcc  acattacct  ctgcgagag  gccctagaa  actgggacc  240
gctgtatcg  gtgctgcca  ggttcgtca  cactatctg  ttctttggc  tcttgggga  300
ccttttagt  ttgtccttc  tccttttgc  ttggcgaca  tggtggtgg  agcaacgac  360
gaggcagca  cgcttaacc  tagcggaaa  ctacctggc  aacttggcg  cttccgatc  420
ggtgtttgt  ctgggcctg  ccttctggg  agagaacat  gggaaccgt  tcaactggc  480
cttcggaac  gacctctgc  gggtggtca  cggggtcat  aaggccaac  tgtttgtca  540
catcttcct  gtggtggct  tcagtcagg  ccgctacag  ctcctggta  accccatga  600
cagctgggg  taccggcgg  gacggcaag  ccaagctac  tgcctgctc  tctgggtag  660
cgggggtct  ttgagcatc  ccacattcc  tctacgctc  gttaaagtc  tccccgatc  720
gaacgtctc  gcctgcatc  tgcttttcc  ccacgaggc  tggcacttt  caaggatgg  780
ggagttgaa  gttttgggt  tcctcctcc  cgtgactgc  atcatcttc  tcaactatc  840
catcctggc  tccctgaga  gacagaagg  ggccagcag  actaggtgt  ggggtccca  900
gggcagcaa  acgacgggg  tgatcctca  actggtagc  tccttcctg  tctgctggt  960
cccttacca  ttcttcgct  tcctggatt  cctggtcca  gtaagagtg  tccaggact  1020
ctcctggaa  gagatcaca  acctgggcc  gcagctcgc  aacttcttt  cctttgtca  1080
cagctgctt  aacccactg  tttatgtct  cgcaggccg  ctccttaag  ccagggttc  1140
ggggacttt  taaatgatg  aaccgagaa  cctcatgcc  atgtggccc  acaggaagg  1200
actcttcca  ttatcctgc  ggaattcaa  cagcaggga  ccaagaagc  tggcttctt  1260
accaaccat  tctggtatc  taaagacca  ctggtcagc  gacccacag  cc  1312



<210> 1497
<211> 337
<212> PRT
<213> Rattus norvegicus
<308> P97583
<400> 1497

Met Ala Ser Glu Val Leu Leu Glu Leu Gln Pro Ser Asn Arg Ser Leu 
  1               5                  10                  15
Gln Ala Pro Ala Asn Ile Thr Ser Cys Glu Ser Ala Leu Glu Asp Trp 
             20                  25                  30
Asp Leu Leu Tyr Arg Val Leu Pro Gly Phe Val Ile Thr Ile Cys Phe 
         35                  40                  45
Phe Gly Leu Leu Gly Asn Leu Leu Val Leu Ser Phe Phe Leu Leu Pro 
     50                  55                  60
Trp Arg Gln Trp Trp Trp Gln Gln Arg Gln Arg Gln Gln Arg Leu Thr 
 65                  70                  75                  80
Ile Ala Glu Ile Tyr Leu Ala Asn Leu Ala Ala Ser Asp Leu Val Phe 
                 85                  90                  95
Val Leu Gly Leu Pro Phe Trp Ala Glu Asn Ile Gly Asn Arg Phe Asn 
             100                105                110
Trp Pro Phe Gly Thr Asp Leu Cys Arg Val Val Ser Gly Val Ile Lys 
         115                120                125
Ala Asn Leu Phe Val Ser Ile Phe Leu Val Val Ala Ile Ser Gln Asp 
     130                135                140
Arg Tyr Arg Leu Leu Val Tyr Pro Met Thr Ser Trp Gly Tyr Arg Arg 
 145                150                155                160
Arg Arg Gln Ala Gln Ala Thr Cys Leu Leu Ile Trp Val Ala Gly Gly 
                 165                170                175
Leu Leu Ser Ile Pro Thr Phe Leu Leu Arg Ser Val Lys Val Val Pro 
             180                185                190
Asp Leu Asn Val Ser Ala Cys Ile Leu Leu Phe Pro His Glu Ala Trp 
         195                200                205
His Phe Ala Arg Met Val Glu Leu Asn Val Leu Gly Phe Leu Leu Pro 
     210                215                220
Val Thr Ala Ile Ile Phe Phe Asn Tyr His Ile Leu Ala Ser Leu Arg 
 225                230                235                240
Gly Gln Lys Glu Ala Ser Arg Thr Arg Cys Gly Gly Pro Lys Gly Ser 
                 245                250                255
Lys Thr Thr Gly Leu Ile Leu Thr Leu Val Ala Ser Phe Leu Val Cys 
             260                265                270
Trp Cys Pro Tyr His Phe Phe Ala Phe Leu Asp Phe Leu Val Gln Val 
         275                280                285
Arg Val Ile Gln Asp Cys Ser Trp Lys Glu Ile Thr Asp Leu Gly Leu 
     290                295                300
Gln Leu Ala Asn Phe Phe Ala Phe Val Asn Ser Cys Leu Asn Pro Leu 
 305                310                315                320
Ile Tyr Val Phe Ala Gly Arg Leu Leu Lys Thr Arg Val Leu Gly Thr 
                 325                330                335
Leu 
             340



<210> 1498
<211> 1302
<212> DNA
<213> Homo sapiens
<308> AJ238044
<400> 1498

aaaactcct  caaaagcag  tctcactat  agaaaaccc  actacagtt  tgaacgcct  60
cattttctg  ctgaggtct  agtccgtcg  cccagactg  agtgcagtg  cacaatcat  120
gctcgctgc  gcctcgacc  tccaggctt  aacgattct  ccacctcag  ctctcgagt  180
gctgggacc  caggtcact  tgcatggca  catcctggc  ccctctaga  ctccaatcc  240
ccaaccaga  ccagctctt  cctcaaaat  ctacggcct  tgacaatgc  ccagaagcc  300
gggacctgc  gcacagagt  ctgccgaca  ttatcatct  catctgttt  ttcggcctc  360
tagggaacc  ttttgtcct  ttggtcttc  tcctgcccc  gcggcaact  aacgtggca  420
aaatctacc  ggccaacct  gcagcctct  atctggtgt  tgtcttggg  ttgcccttc  480
gggcagaga  tatctggaa  cagtttaac  ggcctttcg  agccctcct  tgccgtgtc  540
tcaacgggg  catcaaggc  aatttgttc  tcagcatct  cctggtggt  gccatcagc  600
aggaccgct  ccgcgtgct  gtgcaccct  tggccagcc  gaggcagca  cggcggagg  660
aggcccggg  cacctgcgt  ctcatctgg  ttgtggggg  cctcttgag  atccccaca  720
tcctgctgc  atccatcca  gccgtccca  atctgaaca  caccgcctg  atcctgctc  780
tcccccatg  ggcctggca  tttgcaagg  ttgtggagt  aaatattct  ggtttcctc  840
taccactgg  tgcgatcgt  ttcttcaac  accacatcc  ggcctccct  cgaacgcgg  900
aggaggtca  caggacaag  tgcgggggc  gcaaggata  caagaccac  gcgctgatc  960
tcacgctcg  ggttgcctt  ctggtctgc  gggcccctt  ccacttctt  gccttcctg  1020
aattcttat  ccaggtgca  gcagtccga  gctgctttt  ggaggactt  attgacctg  1080
gcctgcaat  ggccaactt  tttgccttc  ctaacagct  cctgaatcc  gtaatttat  1140
tctttgtgg  ccggctctt  aggaccaag  tctgggaac  ttataaaca  tgcacccct  1200
aaagtcttg  tccaatatc  tcatcccat  ggaaagaaa  cttccaact  ttctggcgg  1260
attaaaaca  cattgaacc  agaaaaaaa  aaaaaaaaa  aa  1302



<210> 1499
<211> 353
<212> PRT
<213> Homo sapiens
<308> P46663
<400> 1499

Met Ala Ser Ser Trp Pro Pro Leu Glu Leu Gln Ser Ser Asn Gln Ser 
  1               5                  10                  15
Gln Leu Phe Pro Gln Asn Ala Thr Ala Cys Asp Asn Ala Pro Glu Ala 
             20                  25                  30
Trp Asp Leu Leu His Arg Val Leu Pro Thr Phe Ile Ile Ser Ile Cys 
         35                  40                  45
Phe Phe Gly Leu Leu Gly Asn Leu Phe Val Leu Leu Val Phe Leu Leu 
     50                  55                  60
Pro Arg Arg Gln Leu Asn Val Ala Glu Ile Tyr Leu Ala Asn Leu Ala 
 65                  70                  75                  80
Ala Ser Asp Leu Val Phe Val Leu Gly Leu Pro Phe Trp Ala Glu Asn 
                 85                  90                  95
Ile Trp Asn Gln Phe Asn Trp Pro Phe Gly Ala Leu Leu Cys Arg Val 
             100                105                110
Ile Asn Gly Val Ile Lys Ala Asn Leu Phe Ile Ser Ile Phe Leu Val 
         115                120                125
Val Ala Ile Ser Gln Asp Arg Tyr Arg Val Leu Val His Pro Met Ala 
     130                135                140
Ser Gly Arg Gln Gln Arg Arg Arg Gln Ala Arg Val Thr Cys Val Leu 
 145                150                155                160
Ile Trp Val Val Gly Gly Leu Leu Ser Ile Pro Thr Phe Leu Leu Arg 
                 165                170                175
Ser Ile Gln Ala Val Pro Asp Leu Asn Ile Thr Ala Cys Ile Leu Leu 
             180                185                190
Leu Pro His Glu Ala Trp His Phe Ala Arg Ile Val Glu Leu Asn Ile 
         195                200                205
Leu Gly Phe Leu Leu Pro Leu Ala Ala Ile Val Phe Phe Asn Tyr His 
     210                215                220
Ile Leu Ala Ser Leu Arg Thr Arg Glu Glu Val Ser Arg Thr Arg Val 
 225                230                235                240
Arg Gly Pro Lys Asp Ser Lys Thr Thr Ala Leu Ile Leu Thr Leu Val 
                 245                250                255
Val Ala Phe Leu Val Cys Trp Ala Pro Tyr His Phe Phe Ala Phe Leu 
             260                265                270
Glu Phe Leu Phe Gln Val Gln Ala Val Arg Gly Cys Phe Trp Glu Asp 
         275                280                285
Phe Ile Asp Leu Gly Leu Gln Leu Ala Asn Phe Phe Ala Phe Thr Asn 
     290                295                300
Ser Ser Leu Asn Pro Val Ile Tyr Val Phe Val Gly Arg Leu Phe Arg 
 305                310                315                320
Thr Lys Val Trp Glu Leu Tyr Lys Gln Cys Thr Pro Lys Ser Leu Ala 
                 325                330                335
Pro Ile Ser Ser Ser His Arg Lys Glu Ile Phe Gln Leu Phe Trp Arg 
             340                345                350
Asn 
         355



<210> 1500
<211> 1946
<212> DNA
<213> Rattus norvegicus
<308> AJ223355
<400> 1500

ccggggtcg  gccaggtcg  tgctgctct  gccatggct  aggcacgca  gtctcgctg  60
tactttgga  ggctggctt  ctgcggagc  gcctgctgc  cgcaccctc  agacctgct  120
aaggtgcat  tgcagaccc  acaggaggt  aagcttcga  tgactggaa  ggcactgca  180
gtggtgcga  ccgatggct  cctggcact  tacaatggc  tgagtgcct  gctgtgcag  240
cagatgacc  actccctga  ccggttcgc  atctacgag  ccatgcggg  ctacatgac  300
aaggacagc  aggggcctc  ccccttcta  agcaaggtg  tgctgggcg  catcagtgg  360
ttaactgga  gcttcgtgg  gaccccagc  gatttggtc  atgtcagga  gcagaatga  420
atgaagctg  ctctgagcc  gcgccgcaa  tactctcac  ccctggatg  tctgtaccg  480
gtagcccgt  aagaaggcc  gaagaagct  ttctctgga  caactatgg  atccagccg  540
ggggccctc  tcactgtgg  ccagctgtc  tgctacgac  aggccaagc  gctggttct  600
agtactggg  acctgagtg  caacatttt  acccacttc  tctccagtt  cattgcggg  660
ggatgtgcc  catttctct  ccagcccct  gacgtgctg  agactcgct  gatgaactc  720
aagggcgag  atcagggtg  tttccattg  gccgtggag  cagcaaagc  tggaccaca  780
gcctttttc  agggtctcg  tcctgcggg  gtccgtctc  tcccccaca  cgtgcttac  840
ttcatgttc  tggagcagc  gcggaagca  ttcggtatc  aagtggcaa  ctgacaccg  900
cagggacac  tgggctgcg  tcagtcgct  tgctgagcc  cttggaaga  taggaaggg  960
gtgggctcc  ttcctcctt  gcctgggcc  gtgctgatc  ccagaagat  cctgttctt  1020
ccacccttg  gctgctggc  acgccttcc  accctgcct  ggccccact  aagtggcac  1080
tctgcccta  tggctccca  gctctcccc  ctgggacgt  ccatcttcc  acccgatga  1140
tcactcaga  gaggtctgg  ctggctggt  tcactgtcc  cacctccct  gctgctacc  1200
tgccctgcc  gtcaagccc  gagaagctg  gtacacttc  tgctcttgc  ggcccactg  1260
acagcttcc  cccaggact  gggtagtgt  gcagggtac  gcccctggc  gcttctgct  1320
accaaatga  tagagcacg  acgcacaca  atacacaca  gcacttacg  cacaagagg  1380
accaccgtg  agtgttctg  aaggtagtg  cttcaggag  gggaacagg  cagcagcac  1440
gatcaccag  aaacgccat  accgcggag  ccggagaaa  tacctgggg  tccctgtgc  1500
cctcccgtg  tcagccttg  ctgctttaa  agtcagttt  tgcggaacc  tcctactca  1560
cagccacta  catcatcag  aactggctg  gtccctcat  cacctgtgc  ctcccttgc  1620
tggcttccc  cagggccag  ggctcatgc  ggagctggg  ctatgatgg  ttcatttta  1680
gtgtcctcc  aggacctgt  ttcccgtat  gcaggggtc  cccctcacc  tccctcagg  1740
ttcaaagca  cctgttttc  ctcaaattg  ggttgtgtg  atatcaacg  gaggttggg  1800
cctgtgccc  tttgcctcc  ctcagcacc  ggccctcac  caggaggtg  gggaggtgg  1860
agtgggccc  ggggcactg  ctacatctc  cttcaggat  taataaacc  agtggccaa  1920
aaaaaaaaa  aaaaaaaaa  aaaaaa  1946



<210> 1501
<211> 287
<212> PRT
<213> Rattus norvegicus
<308> AJ223355
<400> 1501

Met Ala Glu Ala Arg Thr Ser Arg Trp Tyr Phe Gly Gly Leu Ala Ser 
  1               5                  10                  15
Cys Gly Ala Ala Cys Cys Thr His Pro Leu Asp Leu Leu Lys Val His 
             20                  25                  30
Leu Gln Thr Gln Gln Glu Val Lys Leu Arg Met Thr Gly Met Ala Leu 
         35                  40                  45
Gln Val Val Arg Thr Asp Gly Phe Leu Ala Leu Tyr Asn Gly Leu Ser 
     50                  55                  60
Ala Ser Leu Cys Arg Gln Met Thr Tyr Ser Leu Thr Arg Phe Ala Ile 
 65                  70                  75                  80
Tyr Glu Thr Met Arg Asp Tyr Met Thr Lys Asp Ser Gln Gly Pro Leu 
                 85                  90                  95
Pro Phe Tyr Ser Lys Val Leu Leu Gly Gly Ile Ser Gly Leu Thr Gly 
             100                105                110
Gly Phe Val Gly Thr Pro Ala Asp Leu Val Asn Val Arg Met Gln Asn 
         115                120                125
Asp Met Lys Leu Pro Leu Ser Gln Arg Arg Asn Tyr Ser His Ala Leu 
     130                135                140
Asp Gly Leu Tyr Arg Val Ala Arg Glu Glu Gly Leu Lys Lys Leu Phe 
 145                150                155                160
Ser Gly Ala Thr Met Ala Ser Ser Arg Gly Ala Leu Val Thr Val Gly 
                 165                170                175
Gln Leu Ser Cys Tyr Asp Gln Ala Lys Gln Leu Val Leu Ser Thr Gly 
             180                185                190
Tyr Leu Ser Asp Asn Ile Phe Thr His Phe Leu Ser Ser Phe Ile Ala 
         195                200                205
Gly Gly Cys Ala Thr Phe Leu Cys Gln Pro Leu Asp Val Leu Lys Thr 
     210                215                220
Arg Leu Met Asn Ser Lys Gly Glu Tyr Gln Gly Val Phe His Cys Ala 
 225                230                235                240
Val Glu Thr Ala Lys Leu Gly Pro Gln Ala Phe Phe Lys Gly Leu Val 
                 245                250                255
Pro Ala Gly Val Arg Leu Val Pro His Thr Val Leu Thr Phe Met Phe 
             260                265                270
Leu Glu Gln Leu Arg Lys His Phe Gly Ile Lys Val Ala Thr Ter 
         275                280                285



<210> 1502
<211> 1967
<212> DNA
<213> Homo sapiens
<308> BC015797
<400> 1502

cgcgcgggc  gcgctttga  ccgggcgcg  ggcgcgggg  gcggggcgc  gcggccggt  60
cacgccggg  tagggccgg  gtcgggttg  ggtcgggcc  ggattgggc  ctcctgggc  120
atggcagcc  aggcgcgcg  gtcgcgctg  tacttcggg  ggctggcct  ctgcggggc  180
gcctgctgc  cgcacccgc  ggacctgct  aaggtgcat  tgcagacgc  gcaggaggt  240
aagctgcgc  tgacgggca  ggcgctgcg  gtggtgcgt  ccgacggca  cctggcact  300
tacagcggc  tgagcgcct  gctgtgcag  cagatgacc  actccctga  tcggttcgc  360
atctacgag  ctgtgcggg  ccgcgtggc  aagggcagc  aggggcctc  ccccttcca  420
gagaaggtg  tgctgggct  cgtcagcgg  ttagctgga  gcttcgtgg  gacgcccgc  480
gacttggtc  acgtcagga  gcagaacga  gtgaagctg  cccagggtc  gcggcgcaa  540
tacgcccat  cgctggatg  cctgtaccg  gtagctcgt  aagagggtc  caggagact  600
ttctcgggt  caaccatgg  atccagccg  ggggcctta  tcactgtgg  ccagctgtc  660
tgctacgac  aggccaagc  gctggtcct  agcaccggg  acctctctg  caacatctt  720
actcacttt  tcgccagct  tattgcagc  gctggtgac  agccccctc  tcagggtgg  780
tgtgccacg  tcctgtgcc  gcccctgga  gtgctgaag  ctcgcctga  gaactccaa  840
ggggagtat  agggcgttt  ccactgcgc  gtggagaca  cgaagctcg  gcctctggc  900
ttttacaag  gcctcgtcc  agctggcat  cgcctcatc  cccacaccg  gctcacttt  960
gtgtttctg  aacagctac  caaaaactt  ggcatcaaa  tgccatcct  accagccgt  1020
ggaatggct  ggctgccag  ccagacacg  taggttctt  caaagagtc  caagcccag  1080
acctgctcc  ggggccacg  cctccctgg  cgtggccac  catcctccg  agcaggccc  1140
tgctgtccc  ccacctgct  gctgagctc  tcctggcct  gtcccctct  agctgtagc  1200
gcaccaccc  cgctctggc  accaggctc  cccggctgg  cactgcgtg  ccttgcccc  1260
ctcccgctg  cagctcctc  ggggaacag  ggctaccag  ggctgattt  tcccctctc  1320
tgggccagg  gaggggtat  atccctgcc  cctgccccc  atgcccaaa  cagcatctt  1380
cagcacttt  catcgagga  ttgggtggc  gagtgtggg  gcagcctgg  tgttgctca  1440
ccaagtgct  gctctgcac  tcgtgtctg  tgagagcaa  cagaccttc  atgtcctcg  1500
gcagctgca  ctccccgcg  gaccccgca  ctgggtggg  tgaacaagc  acgcagacc  1560
caagcgagt  cctgggagg  agtggccca  agaggttct  gagccattg  gggtgaggg  1620
cgagggcca  cgaggtccc  cgcaccgct  cctgccctg  agtggcttt  acagttagt  1680
ttgccaaag  ctctccact  accagcagg  ggtctctgt  ttcagggat  gtgcctgcg  1740
ccctcgggc  cctgggccc  cccgcttgg  tccctgggg  aatggccca  gcgggccgc  1800
gttcctcct  agggccttc  ccccgacaa  gagtccgac  gggcggatg  tgcatcctc  1860
gcctccctg  tcgctgggc  tcaccccac  tgggaaggg  agtgtgctc  gtgggggct  1920
caatcaata  atgccggga  ctgccaaaa  aaaaaaaaa  aaaaaaa  1967



<210> 1503
<211> 287
<212> PRT
<213> Homo sapiens
<308> Q9UBX3
<400> 1503

Met Ala Ala Glu Ala Arg Val Ser Arg Trp Tyr Phe Gly Gly Leu Ala 
  1               5                  10                  15
Ser Cys Gly Ala Ala Cys Cys Thr His Pro Leu Asp Leu Leu Lys Val 
             20                  25                  30
His Leu Gln Thr Gln Gln Glu Val Lys Leu Arg Met Thr Gly Met Ala 
         35                  40                  45
Leu Arg Val Val Arg Thr Asp Gly Ile Leu Ala Leu Tyr Ser Gly Leu 
     50                  55                  60
Ser Ala Ser Leu Cys Arg Gln Met Thr Tyr Ser Leu Thr Arg Phe Ala 
 65                  70                  75                  80
Ile Tyr Glu Thr Val Arg Asp Arg Val Ala Lys Gly Ser Gln Gly Pro 
                 85                  90                  95
Leu Pro Phe His Glu Lys Val Leu Leu Gly Ser Val Ser Gly Leu Ala 
             100                105                110
Gly Gly Phe Val Gly Thr Pro Ala Asp Leu Val Asn Val Arg Met Gln 
         115                120                125
Asn Asp Val Lys Leu Pro Gln Gly Gln Arg Arg Asn Tyr Ala His Ala 
     130                135                140
Leu Asp Gly Leu Tyr Arg Val Ala Arg Glu Glu Gly Leu Arg Arg Leu 
 145                150                155                160
Phe Ser Gly Ala Thr Met Ala Ser Ser Arg Gly Ala Leu Val Thr Val 
                 165                170                175
Gly Gln Leu Ser Cys Tyr Asp Gln Ala Lys Gln Leu Val Leu Ser Thr 
             180                185                190
Gly Tyr Leu Ser Asp Asn Ile Phe Thr His Phe Val Ala Ser Phe Ile 
         195                200                205
Ala Gly Gly Cys Ala Thr Phe Leu Cys Gln Pro Leu Asp Val Leu Lys 
     210                215                220
Thr Arg Leu Met Asn Ser Lys Gly Glu Tyr Gln Gly Val Phe His Cys 
 225                230                235                240
Ala Val Glu Thr Ala Lys Leu Gly Pro Leu Ala Phe Tyr Lys Gly Leu 
                 245                250                255
Val Pro Ala Gly Ile Arg Leu Ile Pro His Thr Val Leu Thr Phe Val 
             260                265                270
Phe Leu Glu Gln Leu Arg Lys Asn Phe Gly Ile Lys Val Pro Ser 
         275                280                285



<210> 1504
<211> 1946
<212> DNA
<213> Rattus norvegicus
<308> AJ223355
<400> 1504

ccggggtcg  gccaggtcg  tgctgctct  gccatggct  aggcacgca  gtctcgctg  60
tactttgga  ggctggctt  ctgcggagc  gcctgctgc  cgcaccctc  agacctgct  120
aaggtgcat  tgcagaccc  acaggaggt  aagcttcga  tgactggaa  ggcactgca  180
gtggtgcga  ccgatggct  cctggcact  tacaatggc  tgagtgcct  gctgtgcag  240
cagatgacc  actccctga  ccggttcgc  atctacgag  ccatgcggg  ctacatgac  300
aaggacagc  aggggcctc  ccccttcta  agcaaggtg  tgctgggcg  catcagtgg  360
ttaactgga  gcttcgtgg  gaccccagc  gatttggtc  atgtcagga  gcagaatga  420
atgaagctg  ctctgagcc  gcgccgcaa  tactctcac  ccctggatg  tctgtaccg  480
gtagcccgt  aagaaggcc  gaagaagct  ttctctgga  caactatgg  atccagccg  540
ggggccctc  tcactgtgg  ccagctgtc  tgctacgac  aggccaagc  gctggttct  600
agtactggg  acctgagtg  caacatttt  acccacttc  tctccagtt  cattgcggg  660
ggatgtgcc  catttctct  ccagcccct  gacgtgctg  agactcgct  gatgaactc  720
aagggcgag  atcagggtg  tttccattg  gccgtggag  cagcaaagc  tggaccaca  780
gcctttttc  agggtctcg  tcctgcggg  gtccgtctc  tcccccaca  cgtgcttac  840
ttcatgttc  tggagcagc  gcggaagca  ttcggtatc  aagtggcaa  ctgacaccg  900
cagggacac  tgggctgcg  tcagtcgct  tgctgagcc  cttggaaga  taggaaggg  960
gtgggctcc  ttcctcctt  gcctgggcc  gtgctgatc  ccagaagat  cctgttctt  1020
ccacccttg  gctgctggc  acgccttcc  accctgcct  ggccccact  aagtggcac  1080
tctgcccta  tggctccca  gctctcccc  ctgggacgt  ccatcttcc  acccgatga  1140
tcactcaga  gaggtctgg  ctggctggt  tcactgtcc  cacctccct  gctgctacc  1200
tgccctgcc  gtcaagccc  gagaagctg  gtacacttc  tgctcttgc  ggcccactg  1260
acagcttcc  cccaggact  gggtagtgt  gcagggtac  gcccctggc  gcttctgct  1320
accaaatga  tagagcacg  acgcacaca  atacacaca  gcacttacg  cacaagagg  1380
accaccgtg  agtgttctg  aaggtagtg  cttcaggag  gggaacagg  cagcagcac  1440
gatcaccag  aaacgccat  accgcggag  ccggagaaa  tacctgggg  tccctgtgc  1500
cctcccgtg  tcagccttg  ctgctttaa  agtcagttt  tgcggaacc  tcctactca  1560
cagccacta  catcatcag  aactggctg  gtccctcat  cacctgtgc  ctcccttgc  1620
tggcttccc  cagggccag  ggctcatgc  ggagctggg  ctatgatgg  ttcatttta  1680
gtgtcctcc  aggacctgt  ttcccgtat  gcaggggtc  cccctcacc  tccctcagg  1740
ttcaaagca  cctgttttc  ctcaaattg  ggttgtgtg  atatcaacg  gaggttggg  1800
cctgtgccc  tttgcctcc  ctcagcacc  ggccctcac  caggaggtg  gggaggtgg  1860
agtgggccc  ggggcactg  ctacatctc  cttcaggat  taataaacc  agtggccaa  1920
aaaaaaaaa  aaaaaaaaa  aaaaaa  1946



<210> 1505
<211> 287
<212> PRT
<213> Rattus norvegicus
<308> AJ223355
<400> 1505

Met Ala Glu Ala Arg Thr Ser Arg Trp Tyr Phe Gly Gly Leu Ala Ser 
  1               5                  10                  15
Cys Gly Ala Ala Cys Cys Thr His Pro Leu Asp Leu Leu Lys Val His 
             20                  25                  30
Leu Gln Thr Gln Gln Glu Val Lys Leu Arg Met Thr Gly Met Ala Leu 
         35                  40                  45
Gln Val Val Arg Thr Asp Gly Phe Leu Ala Leu Tyr Asn Gly Leu Ser 
     50                  55                  60
Ala Ser Leu Cys Arg Gln Met Thr Tyr Ser Leu Thr Arg Phe Ala Ile 
 65                  70                  75                  80
Tyr Glu Thr Met Arg Asp Tyr Met Thr Lys Asp Ser Gln Gly Pro Leu 
                 85                  90                  95
Pro Phe Tyr Ser Lys Val Leu Leu Gly Gly Ile Ser Gly Leu Thr Gly 
             100                105                110
Gly Phe Val Gly Thr Pro Ala Asp Leu Val Asn Val Arg Met Gln Asn 
         115                120                125
Asp Met Lys Leu Pro Leu Ser Gln Arg Arg Asn Tyr Ser His Ala Leu 
     130                135                140
Asp Gly Leu Tyr Arg Val Ala Arg Glu Glu Gly Leu Lys Lys Leu Phe 
 145                150                155                160
Ser Gly Ala Thr Met Ala Ser Ser Arg Gly Ala Leu Val Thr Val Gly 
                 165                170                175
Gln Leu Ser Cys Tyr Asp Gln Ala Lys Gln Leu Val Leu Ser Thr Gly 
             180                185                190
Tyr Leu Ser Asp Asn Ile Phe Thr His Phe Leu Ser Ser Phe Ile Ala 
         195                200                205
Gly Gly Cys Ala Thr Phe Leu Cys Gln Pro Leu Asp Val Leu Lys Thr 
     210                215                220
Arg Leu Met Asn Ser Lys Gly Glu Tyr Gln Gly Val Phe His Cys Ala 
 225                230                235                240
Val Glu Thr Ala Lys Leu Gly Pro Gln Ala Phe Phe Lys Gly Leu Val 
                 245                250                255
Pro Ala Gly Val Arg Leu Val Pro His Thr Val Leu Thr Phe Met Phe 
             260                265                270
Leu Glu Gln Leu Arg Lys His Phe Gly Ile Lys Val Ala Thr Ter 
         275                280                285



<210> 1506
<211> 1967
<212> DNA
<213> Homo sapiens
<308> BC015797
<400> 1506

cgcgcgggc  gcgctttga  ccgggcgcg  ggcgcgggg  gcggggcgc  gcggccggt  60
cacgccggg  tagggccgg  gtcgggttg  ggtcgggcc  ggattgggc  ctcctgggc  120
atggcagcc  aggcgcgcg  gtcgcgctg  tacttcggg  ggctggcct  ctgcggggc  180
gcctgctgc  cgcacccgc  ggacctgct  aaggtgcat  tgcagacgc  gcaggaggt  240
aagctgcgc  tgacgggca  ggcgctgcg  gtggtgcgt  ccgacggca  cctggcact  300
tacagcggc  tgagcgcct  gctgtgcag  cagatgacc  actccctga  tcggttcgc  360
atctacgag  ctgtgcggg  ccgcgtggc  aagggcagc  aggggcctc  ccccttcca  420
gagaaggtg  tgctgggct  cgtcagcgg  ttagctgga  gcttcgtgg  gacgcccgc  480
gacttggtc  acgtcagga  gcagaacga  gtgaagctg  cccagggtc  gcggcgcaa  540
tacgcccat  cgctggatg  cctgtaccg  gtagctcgt  aagagggtc  caggagact  600
ttctcgggt  caaccatgg  atccagccg  ggggcctta  tcactgtgg  ccagctgtc  660
tgctacgac  aggccaagc  gctggtcct  agcaccggg  acctctctg  caacatctt  720
actcacttt  tcgccagct  tattgcagc  gctggtgac  agccccctc  tcagggtgg  780
tgtgccacg  tcctgtgcc  gcccctgga  gtgctgaag  ctcgcctga  gaactccaa  840
ggggagtat  agggcgttt  ccactgcgc  gtggagaca  cgaagctcg  gcctctggc  900
ttttacaag  gcctcgtcc  agctggcat  cgcctcatc  cccacaccg  gctcacttt  960
gtgtttctg  aacagctac  caaaaactt  ggcatcaaa  tgccatcct  accagccgt  1020
ggaatggct  ggctgccag  ccagacacg  taggttctt  caaagagtc  caagcccag  1080
acctgctcc  ggggccacg  cctccctgg  cgtggccac  catcctccg  agcaggccc  1140
tgctgtccc  ccacctgct  gctgagctc  tcctggcct  gtcccctct  agctgtagc  1200
gcaccaccc  cgctctggc  accaggctc  cccggctgg  cactgcgtg  ccttgcccc  1260
ctcccgctg  cagctcctc  ggggaacag  ggctaccag  ggctgattt  tcccctctc  1320
tgggccagg  gaggggtat  atccctgcc  cctgccccc  atgcccaaa  cagcatctt  1380
cagcacttt  catcgagga  ttgggtggc  gagtgtggg  gcagcctgg  tgttgctca  1440
ccaagtgct  gctctgcac  tcgtgtctg  tgagagcaa  cagaccttc  atgtcctcg  1500
gcagctgca  ctccccgcg  gaccccgca  ctgggtggg  tgaacaagc  acgcagacc  1560
caagcgagt  cctgggagg  agtggccca  agaggttct  gagccattg  gggtgaggg  1620
cgagggcca  cgaggtccc  cgcaccgct  cctgccctg  agtggcttt  acagttagt  1680
ttgccaaag  ctctccact  accagcagg  ggtctctgt  ttcagggat  gtgcctgcg  1740
ccctcgggc  cctgggccc  cccgcttgg  tccctgggg  aatggccca  gcgggccgc  1800
gttcctcct  agggccttc  ccccgacaa  gagtccgac  gggcggatg  tgcatcctc  1860
gcctccctg  tcgctgggc  tcaccccac  tgggaaggg  agtgtgctc  gtgggggct  1920
caatcaata  atgccggga  ctgccaaaa  aaaaaaaaa  aaaaaaa  1967



<210> 1507
<211> 287
<212> PRT
<213> Homo sapiens
<308> Q9UBX3
<400> 1507

Met Ala Ala Glu Ala Arg Val Ser Arg Trp Tyr Phe Gly Gly Leu Ala 
  1               5                  10                  15
Ser Cys Gly Ala Ala Cys Cys Thr His Pro Leu Asp Leu Leu Lys Val 
             20                  25                  30
His Leu Gln Thr Gln Gln Glu Val Lys Leu Arg Met Thr Gly Met Ala 
         35                  40                  45
Leu Arg Val Val Arg Thr Asp Gly Ile Leu Ala Leu Tyr Ser Gly Leu 
     50                  55                  60
Ser Ala Ser Leu Cys Arg Gln Met Thr Tyr Ser Leu Thr Arg Phe Ala 
 65                  70                  75                  80
Ile Tyr Glu Thr Val Arg Asp Arg Val Ala Lys Gly Ser Gln Gly Pro 
                 85                  90                  95
Leu Pro Phe His Glu Lys Val Leu Leu Gly Ser Val Ser Gly Leu Ala 
             100                105                110
Gly Gly Phe Val Gly Thr Pro Ala Asp Leu Val Asn Val Arg Met Gln 
         115                120                125
Asn Asp Val Lys Leu Pro Gln Gly Gln Arg Arg Asn Tyr Ala His Ala 
     130                135                140
Leu Asp Gly Leu Tyr Arg Val Ala Arg Glu Glu Gly Leu Arg Arg Leu 
 145                150                155                160
Phe Ser Gly Ala Thr Met Ala Ser Ser Arg Gly Ala Leu Val Thr Val 
                 165                170                175
Gly Gln Leu Ser Cys Tyr Asp Gln Ala Lys Gln Leu Val Leu Ser Thr 
             180                185                190
Gly Tyr Leu Ser Asp Asn Ile Phe Thr His Phe Val Ala Ser Phe Ile 
         195                200                205
Ala Gly Gly Cys Ala Thr Phe Leu Cys Gln Pro Leu Asp Val Leu Lys 
     210                215                220
Thr Arg Leu Met Asn Ser Lys Gly Glu Tyr Gln Gly Val Phe His Cys 
 225                230                235                240
Ala Val Glu Thr Ala Lys Leu Gly Pro Leu Ala Phe Tyr Lys Gly Leu 
                 245                250                255
Val Pro Ala Gly Ile Arg Leu Ile Pro His Thr Val Leu Thr Phe Val 
             260                265                270
Phe Leu Glu Gln Leu Arg Lys Asn Phe Gly Ile Lys Val Pro Ser 
         275                280                285



<210> 1508
<211> 1194
<212> DNA
<213> Rattus norvegicus
<308> AJ224120
<400> 1508

agagagaga  agagagaga  agagagaga  aacccaccc  cccggcgac  aatctgatc  60
cggctgtcc  ccgggacca  cgaggtccc  gaagaccca  gagggagcg  gcgtaacgc  120
tggctgcgg  tgggagcca  ggacgcctt  atccgagtc  ccaaccaaa  ccaaggtcg  180
gaccgactt  tcagagcca  tcaacacgc  tgcatgttg  ttagatatt  gttagagtc  240
aaggctggc  aagaggcgg  ggtaacgaa  ctcaagaat  tggagacta  tgtgagcac  300
ggccgtaaa  ggttcagac  aggcaacgt  ctccatgcc  tccaggcca  tgagcagag  360
atccaagcc  ctgaccttg  gccccgcct  tgcctaaca  tagccaacc  gaaccgcgt  420
gtttattac  tctgtgaca  tgtcctctg  gcgaagagt  tgggtctga  atctggaat  480
aacagagag  agtggcaaa  gcgggcggc  cgccactac  actatttcc  cttgctgag  540
ctggtccgg  atctgtatg  ggtcttgct  catatggga  aagttgcac  cgacagagc  600
aagagagag  agtcctccg  ggaccctcc  aagtacagc  tcgctaatg  agaaagtga  660
tggctccag  ccttcctcc  cctcctctt  cagtctcta  agcgaaatc  gcccttatt  720
ctggacacc  tgaagaact  ctgtgacat  ctgatccct  tgaaccagc  cgggatcta  780
aagtccaac  ttggcgtgg  aggatttgg  ggtctcgtg  cctctgtgg  tggcctcat  840
actgtggtg  atcctcagt  gaaactgaa  gcccgctag  gtgtttgga  aatttaaga  900
tgacgttca  tggagcaaa  atttgcttt  gtcatgatg  ctactgtac  taatttttt  960
taatcatgt  agcatctta  caaccggtg  tgtgagcag  ggtaggacc  acaacggag  1020
ctgaagact  atgacgttt  tgtaaacac  gcagtaact  ctgcacatt  ccccttcag  1080
gacttctga  tactgcaaa  acatttgtg  cgtcattga  gacgtgtaa  ggggaagtc  1140
gaacattgc  gagcatctt  tctgtacat  gtaagagct  atatatcta  caaa  1194



<210> 1509
<211> 246
<212> PRT
<213> Rattus norvegicus
<308> CAA11838
<400> 1509

Met Asp Ala Phe Ile Arg Val Ala Asn Gln Ser Gln Gly Arg Asp Arg 
  1               5                  10                  15
Leu Phe Arg Ala Thr Gln His Ala Cys Met Leu Leu Arg Tyr Leu Leu 
             20                  25                  30
Glu Ser Lys Ala Gly Lys Glu Ala Val Val Thr Lys Leu Lys Asn Leu 
         35                  40                  45
Glu Thr Ser Val Ser Thr Gly Arg Lys Trp Phe Arg Leu Gly Asn Val 
     50                  55                  60
Leu His Ala Ile Gln Ala Thr Glu Gln Ser Ile Gln Ala Thr Asp Leu 
 65                  70                  75                  80
Val Pro Arg Leu Cys Leu Thr Leu Ala Asn Leu Asn Arg Val Val Tyr 
                 85                  90                  95
Tyr Ile Cys Asp Thr Val Leu Trp Ala Lys Ser Val Gly Leu Thr Ser 
             100                105                110
Gly Ile Asn Arg Glu Lys Trp Gln Met Arg Ala Ala Arg His Tyr Tyr 
         115                120                125
Tyr Phe Leu Leu Leu Ser Leu Val Arg Asp Leu Tyr Glu Val Leu Leu 
     130                135                140
His Met Gly Gln Val Ala Arg Asp Arg Ala Lys Arg Glu Lys Ser Ser 
 145                150                155                160
Gly Asp Pro Pro Lys Tyr Ser Val Ala Asn Glu Glu Ser Glu Trp Leu 
                 165                170                175
Gln Ser Phe Leu Leu Leu Leu Phe Gln Ser Leu Lys Arg Asn Pro Pro 
             180                185                190
Leu Phe Leu Asp Thr Val Lys Asn Phe Cys Asp Ile Leu Ile Pro Leu 
         195                200                205
Asn Gln Leu Gly Ile Tyr Lys Ser Asn Leu Gly Val Val Gly Phe Gly 
     210                215                220
Gly Leu Val Ser Ser Val Ala Gly Leu Ile Thr Val Val Tyr Pro Gln 
 225                230                235                240
Leu Lys Leu Lys Ala Arg 
                 245



<210> 1510
<211> 1208
<212> DNA
<213> Homo sapiens
<308> AK001415
<400> 1510

gtgcgcccg  cccctctgg  gcggagaga  tcagcccct  cccctcagc  gataacctg  60
gactgaccg  tccctgggg  tccgacggg  cccagagga  ccacgcctg  gccccgtgc  120
actcgtggc  tttgggcta  aagccatgg  cgccttcac  cgcttcacc  accagaccc  180
gggccggga  cgactcttc  gagccactc  gtacacatg  atgttgctt  gatatttgt  240
agagcccaa  gctggcaaa  agaaggtgg  aatgaagct  aagaaactg  agtccagtg  300
gagcactgg  cgtaaatgg  tcagactag  caatgtggt  catgctata  aggcaactg  360
gcagagcat  catgccact  acctggtac  tcgcttatg  ttaacatta  ccaacctga  420
ccgtgtgat  tatttcatc  gtgacacca  cctctgggt  aggagcgta  gtctcacct  480
tggcatcaa  aaagagaaa  ggcgaacga  ggctgctca  cactactac  attctcttc  540
gctgagcct  gtcagggat  tgtatgaaa  ctccctgca  atgaaacga  ttacatgtg  600
cagggcaaa  aaagagaaa  cagcatccc  ggatcctct  tggttcagc  tggctgagg  660
ggaaacaga  tggctccaa  cctttctac  tcttttatt  cgatctctg  agcagcatc  720
tcccttgct  ctggacaca  tgaagaacc  ttgtgatat  ctgaaccct  tggaccagc  780
ggggatcta  aaatccaat  ctggcatca  tggacttgg  ggtcttgtg  cctctatag  840
aggcatgat  actgtggca  atcctcaga  gaagctgaa  acccgttag  gtgttttta  900
gcttggaac  agtacctac  ttaaaagat  gcctcttgg  gggacagac  tttgtataa  960
tcacaggcc  tgtcatact  tgcttaagt  cttgttcat  tgagcattt  acaacctgt  1020
atgtgggca  agatgaggc  aagaacgga  aagggagga  catgaagag  tgtatgttt  1080
tggagtgct  gagtgactt  tgaatttct  aatattttc  cttcatcta  cattgattg  1140
acatctctt  tgtgcatag  gggagctta  tatttgctg  atgaataaa  attgaaagg  1200
aaaaattt  1208



<210> 1511
<211> 247
<212> PRT
<213> Homo sapiens
<308> NP_003838
<400> 1511

Met Asp Ala Phe Thr Arg Phe Thr Asn Gln Thr Gln Gly Arg Asp Arg 
  1               5                  10                  15
Leu Phe Arg Ala Thr Gln Tyr Thr Cys Met Leu Leu Arg Tyr Leu Leu 
             20                  25                  30
Glu Pro Lys Ala Gly Lys Glu Lys Val Val Met Lys Leu Lys Lys Leu 
         35                  40                  45
Glu Ser Ser Val Ser Thr Gly Arg Lys Trp Phe Arg Leu Gly Asn Val 
     50                  55                  60
Val His Ala Ile Gln Ala Thr Glu Gln Ser Ile His Ala Thr Asp Leu 
 65                  70                  75                  80
Val Pro Arg Leu Cys Leu Thr Leu Ala Asn Leu Asn Arg Val Ile Tyr 
                 85                  90                  95
Phe Ile Cys Asp Thr Ile Leu Trp Val Arg Ser Val Gly Leu Thr Ser 
             100                105                110
Gly Ile Asn Lys Glu Lys Trp Arg Thr Arg Ala Ala His His Tyr Tyr 
         115                120                125
Tyr Ser Leu Leu Leu Ser Leu Val Arg Asp Leu Tyr Glu Ile Ser Leu 
     130                135                140
Gln Met Lys Arg Val Thr Cys Asp Arg Ala Lys Lys Glu Lys Ser Ala 
 145                150                155                160
Ser Gln Asp Pro Leu Trp Phe Ser Val Ala Glu Glu Glu Thr Glu Trp 
                 165                170                175
Leu Gln Ser Phe Leu Leu Leu Leu Phe Arg Ser Leu Lys Gln His Pro 
             180                185                190
Pro Leu Leu Leu Asp Thr Val Lys Asn Leu Cys Asp Ile Leu Asn Pro 
         195                200                205
Leu Asp Gln Leu Gly Ile Tyr Lys Ser Asn Pro Gly Ile Ile Gly Leu 
     210                215                220
Gly Gly Leu Val Ser Ser Ile Ala Gly Met Ile Thr Val Ala Tyr Pro 
 225                230                235                240
Gln Met Lys Leu Lys Thr Arg 
                 245



<210> 1512
<211> 580
<212> DNA
<213> Rattus norvegicus
<308> AJ224879
<400> 1512

aaacacacc  gtaagtggg  caagaccat  atcgagtac  gatcacaga  gacctcacg  60
cttcccatt  ttgacattg  acccatgga  atcggaggg  ctgatcagg  atttggtgt  120
gacataggg  ctgtctgtt  cttgtaaaa  cctcaaccc  aaaacaaca  aatccattg  180
gaacccaaa  gacccaaat  ctttctaac  gcagtcact  taggatctg  actgaatgg  240
tgacctgac  tgatattca  ctatcctaa  ctcacagtc  ggaccattc  cccctttct  300
agagacctg  actgggcag  ctgcaaaat  aaatctcga  gttctattt  tttattgtc  360
tcctgtaag  cctttgggt  aaggcggag  caggaacta  ctggtgtga  tcagacgcc  420
cccgagtga  tgctcccag  ccagccaga  gacccctac  ggtgctggg  acaggaact  480
tatgtccta  acaatggtg  tattttgtg  caaacacct  tgtattttt  aaaacacca  540
ttgatatta  aaaccaaaa  aaaaaaaat  attggaaagg  580



<210> 1513
<211> 1419
<212> PRT
<213> Rattus norvegicus
<308> AAA79780
<400> 1513

Met Ile Arg Leu Gly Ala Pro Gln Ser Leu Val Leu Leu Thr Leu Leu 
  1               5                  10                  15
Ile Ala Thr Val Leu Gln Cys Gln Gly Gln Asp Ala Arg Lys Leu Gly 
             20                  25                  30
Pro Lys Gly Gln Lys Gly Glu Pro Gly Asp Ile Lys Asp Ile Ile Gly 
         35                  40                  45
Pro Lys Gly Pro Pro Gly Pro Gln Gly Pro Ala Gly Glu Gln Gly Pro 
     50                  55                  60
Arg Gly Asp Arg Gly Asp Lys Gly Glu Arg Gly Ala Pro Gly Pro Arg 
 65                  70                  75                  80
Gly Arg Asp Gly Glu Pro Gly Thr Pro Gly Asn Pro Gly Pro Pro Gly 
                 85                  90                  95
Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Gly Asn Phe Ala 
             100                105                110
Ala Gln Met Ala Gly Gly Phe Asp Glu Lys Ala Gly Gly Ala Gln Met 
         115                120                125
Gly Val Met Gln Gly Pro Met Gly Pro Met Gly Pro Arg Gly Pro Pro 
     130                135                140
Gly Pro Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Asn Pro Gly 
 145                150                155                160
Glu Pro Gly Glu Pro Gly Val Ser Gly Pro Ile Gly Pro Arg Gly Pro 
                 165                170                175
Pro Gly Pro Ala Gly Lys Pro Gly Asp Asp Gly Glu Ala Gly Lys Pro 
             180                185                190
Gly Lys Ala Gly Glu Arg Gly Leu Pro Gly Pro Gln Gly Ala Arg Gly 
         195                200                205
Phe Pro Gly Thr Pro Gly Leu Pro Gly Val Lys Gly His Arg Gly Tyr 
     210                215                220
Pro Gly Leu Asp Gly Ala Lys Gly Glu Ala Gly Ala Pro Gly Val Lys 
 225                230                235                240
Gly Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro Gly Pro Met Gly 
                 245                250                255
Pro Arg Gly Leu Pro Gly Glu Arg Gly Arg Thr Gly Pro Ala Gly Ala 
             260                265                270
Ala Gly Ala Arg Gly Asn Asp Gly Gln Pro Gly Pro Ala Gly Pro Pro 
         275                280                285
Gly Pro Val Gly Pro Ala Gly Gly Pro Gly Phe Leu Gly Ala Pro Gly 
     290                295                300
Ala Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly Pro Glu Gly Ala 
 305                310                315                320
Gln Gly Ser Arg Gly Glu Pro Gly Asn Pro Gly Ser Pro Gly Pro Ala 
                 325                330                335
Gly Ala Ser Gly Asn Pro Gly Thr Asp Gly Ile Pro Gly Ala Lys Gly 
             340                345                350
Ser Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Pro 
         355                360                365
Arg Gly Pro Pro Gly Pro Gln Gly Ala Thr Gly Pro Leu Gly Pro Lys 
     370                375                380
Gly Gln Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly 
 385                390                395                400
Pro Lys Gly Glu Thr Gly Pro Ala Gly Pro Gln Gly Ala Pro Gly Pro 
                 405                410                415
Ala Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Gly Ala 
             420                425                430
Gly Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly 
         435                440                445
Phe Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly Ala Pro Gly Glu 
     450                455                460
Arg Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala Asn Gly Asp Pro 
 465                470                475                480
Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Thr Gly 
                 485                490                495
Arg Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly Pro Ser Gly Ala 
             500                505                510
Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro Gln Gly Ala Arg 
         515                520                525
Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Asn Gly 
     530                535                540
Glu Pro Gly Lys Ala Gly Glu Lys Gly Leu Ala Gly Ala Pro Gly Leu 
 545                550                555                560
Arg Gly Leu Pro Gly Lys Asp Gly Glu Thr Gly Ala Ala Gly Pro Pro 
                 565                570                575
Gly Pro Ser Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Ala Pro Gly 
             580                585                590
Pro Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Glu 
         595                600                605
Gly Gly Lys Gln Gly Asp Gln Gly Ile Pro Gly Glu Ala Gly Ala Pro 
     610                615                620
Gly Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly 
 625                630                635                640
Ser Pro Gly Ala Gln Gly Leu Gln Gly Pro Arg Gly Leu Pro Gly Thr 
                 645                650                655
Pro Gly Thr Asp Gly Pro Lys Gly Ala Ala Gly Pro Asp Gly Pro Pro 
             660                665                670
Gly Ala Gln Gly Pro Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly 
         675                680                685
Ala Ala Gly Ile Ala Gly Pro Lys Gly Asp Arg Gly Asp Val Gly Glu 
     690                695                700
Lys Gly Pro Glu Gly Ala Pro Gly Lys Asp Gly Gly Arg Gly Leu Thr 
 705                710                715                720
Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Asn Gly Glu Lys Gly 
                 725                730                735
Glu Val Gly Pro Pro Gly Pro Ser Gly Ser Thr Gly Ala Arg Gly Ala 
             740                745                750
Pro Gly Glu Arg Gly Glu Thr Gly Pro Pro Gly Pro Ala Gly Phe Ala 
         755                760                765
Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Asp Gln Gly 
     770                775                780
Glu Ala Gly Gln Lys Gly Asp Ala Gly Ala Pro Gly Pro Gln Gly Pro 
 785                790                795                800
Ser Gly Ala Pro Gly Pro Gln Gly Pro Thr Gly Val Thr Gly Pro Lys 
                 805                810                815
Gly Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly 
             820                825                830
Ala Ala Gly Arg Val Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro 
         835                840                845
Ala Gly Pro Pro Gly Pro Ala Gly Lys Asp Gly Pro Lys Gly Ala Arg 
     850                855                860
Gly Asp Thr Gly Ala Pro Gly Arg Ala Gly Asp Pro Gly Leu Gln Gly 
 865                870                875                880
Pro Ala Gly Ala Pro Gly Glu Lys Gly Glu Pro Gly Asp Asp Gly Pro 
                 885                890                895
Ser Gly Ser Asp Gly Pro Pro Gly Pro Gln Gly Leu Ala Gly Gln Arg 
             900                905                910
Gly Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly 
         915                920                925
Leu Pro Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Ala Pro Gly Ala 
     930                935                940
Ser Gly Asp Arg Gly Pro Pro Gly Pro Val Gly Pro Pro Gly Leu Thr 
 945                950                955                960
Gly Pro Ala Gly Glu Pro Gly Arg Glu Gly Ser Pro Gly Ala Asp Gly 
                 965                970                975
Pro Pro Gly Arg Asp Gly Ala Ala Gly Val Lys Gly Asp Arg Gly Glu 
             980                985                990
Thr Gly Ala Leu Gly Ala Pro Gly Ala Pro Gly Pro Pro Gly Ser Pro 
         995                1000                1005
Gly Pro Ala Gly Pro Thr Gly Lys Gln Gly Asp Arg Gly Glu Ala Gly 
     1010                1015                1020
Ala Gln Gly Pro Met Gly Pro Ser Gly Pro Ala Gly Ala Arg Gly Ile 
 1025                1030                1035                1040
Ala Gly Pro Gln Gly Pro Arg Gly Asp Lys Gly Glu Ala Gly Glu Pro 
                 1045                1050                1055
Gly Glu Arg Gly Leu Lys Gly His Arg Gly Phe Thr Gly Leu Gln Gly 
             1060                1065                1070
Leu Pro Gly Pro Pro Gly Pro Ser Gly Asp Gln Gly Thr Ser Gly Pro 
         1075                1080                1085
Ala Gly Pro Ser Gly Pro Arg Gly Pro Pro Gly Pro Val Gly Pro Ser 
     1090                1095                1100
Gly Lys Asp Gly Ser Asn Gly Ile Pro Gly Pro Ile Gly Pro Pro Gly 
 1105                1110                1115                1120
Pro Arg Gly Arg Ser Gly Glu Thr Gly Pro Ala Gly Pro Pro Gly Asn 
                 1125                1130                1135
Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Ile Asp Met 
             1140                1145                1150
Ser Ala Phe Ala Gly Leu Gly Gln Arg Glu Lys Gly Pro Asp Pro Leu 
         1155                1160                1165
Gln Tyr Met Arg Ala Asp Glu Ala Asp Ser Thr Leu Arg Gln His Asp 
     1170                1175                1180
Val Glu Val Asp Ala Thr Leu Lys Ser Leu Asn Asn Gln Ile Glu Ser 
 1185                1190                1195                1200
Ile Arg Ser Pro Asp Gly Ser Arg Lys Asn Pro Ala Arg Thr Cys Gln 
                 1205                1210                1215
Asp Leu Lys Leu Cys His Pro Glu Trp Lys Ser Gly Asp Tyr Trp Ile 
             1220                1225                1230
Asp Pro Asn Gln Gly Cys Thr Leu Asp Ala Met Lys Val Phe Cys Asn 
         1235                1240                1245
Met Glu Thr Gly Glu Ser Cys Val Tyr Pro Asn Pro Ala Thr Val Pro 
     1250                1255                1260
Arg Lys Asn Trp Trp Ser Ser Lys Ser Lys Glu Lys Lys His Ile Trp 
 1265                1270                1275                1280
Phe Gly Glu Thr Met Asn Gly Gly Phe His Phe Ser Tyr Gly Asp Gly 
                 1285                1290                1295
Asn Leu Ala Pro Asn Thr Ala Asn Val Gln Met Thr Phe Leu Arg Leu 
             1300                1305                1310
Leu Ser Thr Glu Gly Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser 
         1315                1320                1325
Ile Ala Tyr Leu Asp Glu Ala Ala Gly Asn Leu Lys Lys Ala Leu Leu 
     1330                1335                1340
Ile Gln Gly Ser Asn Asp Val Glu Met Arg Ala Glu Gly Asn Ser Arg 
 1345                1350                1355                1360
Phe Thr Tyr Thr Ala Leu Lys Asp Gly Cys Thr Lys His Thr Gly Lys 
                 1365                1370                1375
Trp Gly Lys Thr Ile Ile Glu Tyr Arg Ser Gln Lys Thr Ser Arg Leu 
             1380                1385                1390
Pro Ile Val Asp Ile Ala Pro Met Asp Ile Gly Gly Pro Asp Gln Glu 
         1395                1400                1405
Phe Gly Val Asp Ile Gly Pro Val Cys Phe Leu 
     1410                1415



<210> 1514
<211> 327
<212> DNA
<213> Rattus norvegicus
<308> C06598
<400> 1514

gggctgcag  tttgacagc  gcctaccac  gaaccagcc  tttgttttc  cccttggca  60
tggccaggt  atcaagggc  gggaccagg  gctactggg  atgtgtgaa  gggaaaagc  120
gaagctagt  atcccgtct  agctggggt  tgganagcg  ggagccccc  caaanatac  180
aggtggagc  accctggtg  ttgaggtgg  actgctcaa  attganaga  gttcanaac  240
gtancaggc  gcaaagggg  aggaggccc  tatcaggga  canactgtt  aaaaacaaa  300
aaaaaaacc  ttaaaaccc  aaaaaaa  327



<210> 1515
<211> 562
<212> DNA
<213> Homo sapiens
<308> M75099
<400> 1515

gttgactcc  ggggcgcgg  gaggagaga  atgaggctg  gctggttcc  ggtcctgac  60
gtactgtcc  tctgcctga  cgccgtggc  acggccacg  gggccgagg  caaaaggaa  120
ctgcagatc  gggtcaaga  gcgggtgga  cactgtccc  tcaaatcgc  caaagggga  180
gtcctgcac  tgcactaca  ggggaagct  gaagatggg  cagagtttg  cagcagcct  240
ccccagaac  agccctttg  cttctccct  ggcacaggc  aggtcatca  gggctggga  300
caggggctg  tggggatgt  tgaggggga  aagcgcaag  tggtgatcc  atccgagct  360
gggtatgga  agcggggag  tcccccaaa  attccaggc  gtgcaaccc  ggtgttcga  420
gtggagctg  tcaaaatag  gcgacgaac  gagctgtaa  cagactggg  aggggcagg  480
ggagaggcc  ccatcaggg  ccagactgt  ccaaaaaaa  aacaaaaaa  aaaaacaaa  540
aaaaaaaca  ttaaaagcc  ag  562



<210> 1516
<211> 141
<212> PRT
<213> Homo sapiens
<308> P26885
<400> 1516

Met Arg Leu Ser Trp Phe Arg Val Leu Thr Val Leu Ser Ile Cys Leu 
  1               5                  10                  15
Ser Ala Val Ala Ser Thr Gly Thr Glu Gly Lys Arg Lys Leu Gln Ile 
             20                  25                  30
Gly Val Lys Lys Arg Val Asp His Cys Pro Ile Lys Ser Arg Lys Gly 
         35                  40                  45
Asp Val Leu His Met His Tyr Thr Gly Lys Leu Glu Asp Gly Thr Glu 
     50                  55                  60
Phe Asp Ser Ser Leu Pro Gln Asn Gln Pro Phe Val Phe Ser Leu Gly 
 65                  70                  75                  80
Thr Gly Gln Val Ile Lys Gly Trp Asp Gln Gly Leu Leu Gly Met Tyr 
                 85                  90                  95
Glu Gly Glu Lys Arg Lys Leu Val Ile Pro Ser Glu Leu Gly Tyr Gly 
             100                105                110
Glu Arg Gly Ala Pro Pro Lys Ile Pro Gly Gly Ala Thr Leu Val Phe 
         115                120                125
Glu Val Glu Leu Leu Lys Ile Glu Arg Arg Thr Glu Leu 
     130                135                140



<210> 1517
<211> 1370
<212> DNA
<213> Rattus norvegicus
<308> D00092
<400> 1517

gggcctgag  cttttaaaa  ttatacatt  gattcagca  cagctgcca  acaggcagc  60
ccagcccca  ctgcagctc  agctgctgc  ccagctgca  cttctgcaa  tgctccagg  120
agctcctat  ccgttcaca  gcagattgt  cttcctgcc  tctccccaa  catgaccat  180
ggcaccgtc  agaggtggg  aaagaaagt  ggagagaag  tgagtgaag  agacttgct  240
gcagagata  agaccgaca  ggccaccat  ggctttgaa  tacaagaag  aggttatct  300
gcaaaaatc  tggtccctg  aggcacaag  gatgttcct  tgggaaccc  gctatgtat  360
atagtagaa  aacaggaag  tatagcagc  tttgcagac  acaggccaa  agaagtgac  420
agcttaaag  cacaggcac  accacctgt  ccaccccca  tggcagctg  tcctcccat  480
ccccagcct  tagcaccta  cccctcagc  gctcctgct  gaccaaagg  aagggtgtt  540
gttagccct  ttgcaaaga  attggcagc  gagaaaggg  ttgacctca  ccaagttaa  600
gggacggga  cagaaggca  aatcatcaa  aaggacatt  actcttttg  gcctactaa  660
gctgctcct  ccgctgcag  agctgctcc  ccgggtcca  gagtggcac  aactcctgc  720
ggtgtcttc  tagacatcc  catcagcaa  attcgtcga  tgattgcgc  gaggctcat  780
cagtcgaag  agactatac  tcattatta  ctttctgtt  atgtaaata  gggagaggt  840
ctgttggtg  ggaaggaac  taataagat  cttgaaggt  aaggaaaaa  ctccgtcaa  900
gacttcatc  taaaagctt  agctttggc  tgcctgaaa  ttcctgaag  aaactcatc  960
tggatggac  cagttatac  acaaaatca  gtggttgat  tcagcgttg  tgtcagtac  1020
cctgcagga  ttatcaccc  tattgtgtt  aatgcacac  taaaaggac  ggaaaccat  1080
gctagtgat  ttgtttctt  agcctccaa  gcaagagag  gtaaacttc  gcctcacga  1140
ttccagggt  ggacattta  aatctccaa  ttagggatg  tcggaatta  gaatttctc  1200
gcgattatt  acccacctc  ggcatgtat  ttggcaatt  gtgcttccg  ggataaact  1260
atccctgca  ataatgaga  aggctttga  gtggctagt  tgatgtctg  cacacactc  1320
gctgtgatc  tcgagttgt  gatggagca  ttggagccc  gtggcttgct  1370



<210> 1518
<211> 555
<212> PRT
<213> Rattus norvegicus
<308> BAA20956
<400> 1518

Ser Leu Pro Pro His Gln Lys Val Pro Leu Pro Ser Leu Ser Pro Thr 
  1               5                  10                  15
Met Gln Ala Gly Thr Ile Ala Arg Trp Glu Lys Lys Glu Gly Glu Lys 
             20                  25                  30
Ile Ser Glu Gly Asp Leu Ile Ala Glu Val Glu Thr Asp Lys Ala Thr 
         35                  40                  45
Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr Met Ala Lys Ile Leu Val 
     50                  55                  60
Pro Glu Gly Thr Arg Asp Val Pro Ile Gly Cys Ile Ile Cys Ile Thr 
 65                  70                  75                  80
Val Glu Lys Pro Gln Asp Ile Glu Ala Phe Lys Asn Tyr Thr Leu Asp 
                 85                  90                  95
Ser Ala Thr Ala Ala Thr Gln Ala Ala Pro Ala Pro Ala Ala Ala Pro 
             100                105                110
Ala Ala Ala Pro Ala Ala Pro Ser Ala Ser Ala Pro Gly Ser Ser Tyr 
         115                120                125
Pro Val His Met Gln Ile Val Leu Pro Ala Leu Ser Pro Thr Met Thr 
     130                135                140
Met Gly Thr Val Gln Arg Trp Glu Lys Lys Val Gly Glu Lys Leu Ser 
 145                150                155                160
Glu Gly Asp Leu Leu Ala Glu Ile Glu Thr Asp Lys Ala Thr Ile Gly 
                 165                170                175
Phe Glu Val Gln Glu Glu Gly Tyr Leu Ala Lys Ile Leu Val Pro Glu 
             180                185                190
Gly Thr Arg Asp Val Pro Leu Gly Thr Pro Leu Cys Ile Ile Val Glu 
         195                200                205
Lys Gln Glu Asp Ile Ala Ala Phe Ala Asp Tyr Arg Pro Thr Glu Val 
     210                215                220
Thr Ser Leu Lys Pro Gln Ala Pro Pro Pro Val Pro Pro Pro Val Ala 
 225                230                235                240
Ala Val Pro Pro Ile Pro Gln Pro Leu Ala Pro Thr Pro Ser Ala Ala 
                 245                250                255
Pro Ala Gly Pro Lys Gly Arg Val Phe Val Ser Pro Leu Ala Lys Lys 
             260                265                270
Leu Ala Ala Glu Lys Gly Ile Asp Leu Thr Gln Val Lys Gly Thr Gly 
         275                280                285
Pro Glu Gly Arg Ile Ile Lys Lys Asp Ile Asp Ser Phe Val Pro Thr 
     290                295                300
Lys Ala Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro Gly Pro Arg Val 
 305                310                315                320
Ala Pro Thr Pro Ala Gly Val Phe Ile Asp Ile Pro Ile Ser Asn Ile 
                 325                330                335
Arg Arg Val Ile Ala Gln Arg Leu Met Gln Ser Lys Gln Thr Ile Pro 
             340                345                350
His Tyr Tyr Leu Ser Val Asp Val Asn Met Gly Glu Val Leu Leu Val 
         355                360                365
Arg Lys Glu Leu Asn Lys Met Leu Glu Gly Lys Gly Lys Ile Ser Val 
     370                375                380
Asn Asp Phe Ile Ile Lys Ala Ser Ala Leu Ala Cys Leu Lys Val Pro 
 385                390                395                400
Glu Ala Asn Ser Ser Trp Met Asp Thr Val Ile Arg Gln Asn His Val 
                 405                410                415
Val Asp Val Ser Val Ala Val Ser Thr Pro Ala Gly Leu Ile Thr Pro 
             420                425                430
Ile Val Phe Asn Ala His Ile Lys Gly Leu Glu Thr Ile Ala Ser Asp 
         435                440                445
Val Val Ser Leu Ala Ser Lys Ala Arg Glu Gly Lys Leu Gln Pro His 
     450                455                460
Glu Phe Gln Gly Gly Thr Phe Thr Ile Ser Asn Leu Gly Met Phe Gly 
 465                470                475                480
Ile Lys Asn Phe Ser Ala Ile Ile Asn Pro Pro Gln Ala Cys Ile Leu 
                 485                490                495
Ala Ile Gly Ala Ser Glu Asp Lys Leu Ile Pro Ala Asp Asn Glu Lys 
             500                505                510
Gly Phe Asp Val Ala Ser Val Met Ser Val Thr Leu Ser Cys Asp His 
         515                520                525
Arg Val Val Asp Gly Ala Val Gly Ala Gln Trp Leu Ala Glu Phe Lys 
     530                535                540
Lys Tyr Leu Glu Lys Pro Val Thr Met Leu Leu 
 545                550                555



<210> 1519
<211> 3219
<212> DNA
<213> Homo sapiens
<308> XM_041355
<400> 1519

acaaacctg  aacgaaatc  ttgcaacca  tacagcctg  gcggggcgc  gcccagtcc  60
tcccccttc  gatgcgcag  agcagaggt  accacgccg  acccctcga  tccctcgcg  120
gcgattcct  gctccttca  caccccagc  ctccaagac  cccgccctt  ggcctgagg  180
tcccactgc  ctagccagt  cccgggctc  cttccagct  ttccagaaa  cttggccac  240
cccctcggc  cagactctc  ggccactcg  ccgcaatta  cccgcgtct  tgcgccttt  300
taggcccct  cccctcggt  gtgcccttg  catctctta  gccccgtct  accctttcg  360
atgcctccc  tagaaccct  ccactttcc  cccctttcc  tctgttatt  ctcccaaac  420
tgcgcccgc  caggcccct  tggaacact  ctgccccgt  gtgcccctc  tccccgctc  480
gtagagaaa  agcgtgcgt  ccgcgcatt  ctggcctgg  gagcgggtg  agtaaacct  540
cgggaacca  tttacgaca  cgtgcggct  tgcggtgtg  ctgacggca  cgccgctgc  600
cttggagag  tcactccgg  gacggcgtt  gttttgggg  gtggggggt  ggtggcact  660
tgtggcgcg  ctgtgcgcg  cgggctcag  atgtagccc  atgggcggg  ctcgaggct  720
ggtggacgg  cttgcagga  gtacccgga  ctccacgag  gacctcgcg  tctggcccg  780
ctcccgctc  tcgcaacag  gtgactaca  ggtatggcg  ggtccgggc  ctgtgcggc  840
ggaccccca  ttctggggc  acgccgcgg  accgcttac  gctgcagct  ttggggtcg  900
ccggccgcc  ctattacag  cttcccccg  atcagaagg  tccattgcc  tctctttcc  960
ccacaatgc  ggcaggcac  atagcccgt  gggaaaaaa  agaggggga  caaatcaat  1020
aaggtgacc  aattgcaga  gttgaaact  ataaagcca  tgttggatt  gagagcctg  1080
aggagtgtt  tatggcaaa  atacttgtt  ctgaaggta  cagggatgt  cccatcgga  1140
cgatcatct  tatcacagt  ggcaagcct  aggatattg  ggcctttaa  aattataca  1200
tggattcct  agcagcacc  accccacaa  cggccccag  accaacccc  gctgccact  1260
cttcgccac  tacaccttc  gctcaggct  ctggtagct  atatccccc  cacatgcag  1320
tacttcttc  tgccctctc  cccaccatg  ccatgggca  agttcagag  tgggaaaaa  1380
aagtgggtg  gaagctaag  gaaggagac  tactggcag  gatagaaac  gacaaagcc  1440
ctataggtt  tgaagtaca  gaagaaggt  atctggcaa  aatcctggt  cctgaaggc  1500
caagagatg  ccctctagg  accccactc  gtatcattg  agaaaaaga  gcagatata  1560
cagcatttg  tgactatag  ccaaccgaa  taacagatt  aaaaccaca  gcgccacca  1620
ctaccccac  cccggtggc  gctgttcct  caactcccc  gcctttagc  cctacacct  1680
cagcaccct  cccagctac  cctgctgga  caaagggaa  ggtgtttgt  agccctctt  1740
caaagaagt  ggcagtaga  aaagggatt  atcttacac  agtaaaagg  acaggacca  1800
atggtagaa  caccaagaa  gatatcgac  cttttgtgc  tagtaaagt  gctcctgct  1860
cggcagctg  tgtgcctcc  acaggtcct  gaatggcac  agttcctac  ggtgtcttc  1920
cagatatcc  aatcagcaa  attcgtcgg  ttattgcac  gcgattaat  caatcaaag  1980
aaaccatac  tcattatta  ctttctatc  atgtaaata  gggagaagt  ttgttggta  2040
ggaaagaac  taataagat  ttagaaggg  gaagcaaaa  ttctgtcaa  gacttcatc  2100
taaaagctt  agctttggc  tgtttaaaa  ttcccgaag  aaattcttc  tggatggac  2160
cagttataa  acaaaatca  gttgttgat  tcagtgttg  ggtcagtac  cctgcagga  2220
tcatcacac  tattgtgtt  aatgcacat  taaaaggag  ggaaaccat  gctaatgat  2280
ttgtttctt  agcaaccaa  gcaagagag  gtaaactac  gccacatga  ttccagggt  2340
gcactttta  gatctccaa  ttaggaatg  ttggaatta  gaatttctc  gctattatt  2400
acccacctc  agcatgtat  ttggcaatt  gtgcttcag  ggataaact  gtccctgca  2460
ataatgaaa  agggtttga  gtggctagc  tgatgtctg  tacactcag  tgtgatcac  2520
gggtggtgg  tggagcagt  ggagcccag  ggcttgctg  gtttagaaa  taccttgaa  2580
aacctatca  tatgttgtt  taactaact  aagaatttc  aaactctcc  aggtcacac  2640
gattcattc  taacaagat  tttatatgt  attaaacag  tggttcttt  tattttaaa  2700
agttatttt  attattgag  ctgtccaga  aagttattt  taatgggca  tactgaatt  2760
ttaaaatgc  gattacacc  aaatattgt  cacatttaa  aatcagaca  cagattttt  2820
gctctgtac  cctaattaa  ggacatgta  gtggccttg  ctagccctt  ggtgataag  2880
acttcctct  ggaaatgta  gataggtag  attgtggtt  cctaaagac  agtacataa  2940
ggtgaccct  atgaaacct  gaagttctg  aatttaact  cctaaaatg  tctccttag  3000
tgtgagaga  agagaaatc  ggaaaatta  ttctcttgg  ggaagggct  gaattgaag  3060
tttacttta  aatttagcc  tggtttgaa  ttttccatt  catgatctt  gtttatcat  3120
gatgggaag  gtagaaaac  tcaaggaaa  taagtgaaa  tttaaaagt  agcattttc  3180
tagacctct  cagctgatt  tttattttt  tatgaattc  3219



<210> 1520
<211> 647
<212> PRT
<213> Homo sapiens
<308> XP_041355
<400> 1520

Met Trp Arg Val Cys Ala Arg Arg Ala Gln Asn Val Ala Pro Trp Ala 
  1               5                  10                  15
Gly Leu Glu Ala Arg Trp Thr Ala Leu Gln Glu Val Pro Gly Thr Pro 
             20                  25                  30
Arg Val Thr Ser Arg Ser Gly Pro Ala Pro Ala Arg Arg Asn Ser Val 
         35                  40                  45
Thr Thr Gly Tyr Gly Gly Val Arg Ala Leu Cys Gly Trp Thr Pro Ser 
     50                  55                  60
Ser Gly Ala Thr Pro Arg Asn Arg Leu Leu Leu Gln Leu Leu Gly Ser 
 65                  70                  75                  80
Pro Gly Arg Arg Tyr Tyr Ser Leu Pro Pro His Gln Lys Val Pro Leu 
                 85                  90                  95
Pro Ser Leu Ser Pro Thr Met Gln Ala Gly Thr Ile Ala Arg Trp Glu 
             100                105                110
Lys Lys Glu Gly Asp Gln Ile Asn Glu Gly Asp Leu Ile Ala Glu Val 
         115                120                125
Glu Thr Asp Lys Ala Thr Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr 
     130                135                140
Met Ala Lys Ile Leu Val Ala Glu Gly Thr Arg Asp Val Pro Ile Gly 
 145                150                155                160
Ala Ile Ile Cys Ile Thr Val Gly Lys Pro Glu Asp Ile Glu Ala Phe 
                 165                170                175
Lys Asn Tyr Thr Leu Asp Ser Ser Ala Ala Pro Thr Pro Gln Ala Ala 
             180                185                190
Pro Ala Pro Thr Pro Ala Ala Thr Ala Ser Pro Pro Thr Pro Ser Ala 
         195                200                205
Gln Ala Pro Gly Ser Ser Tyr Pro Pro His Met Gln Val Leu Leu Pro 
     210                215                220
Ala Leu Ser Pro Thr Met Thr Met Gly Thr Val Gln Arg Trp Glu Lys 
 225                230                235                240
Lys Val Gly Glu Lys Leu Ser Glu Gly Asp Leu Leu Ala Glu Ile Glu 
                 245                250                255
Thr Asp Lys Ala Thr Ile Gly Phe Glu Val Gln Glu Glu Gly Tyr Leu 
             260                265                270
Ala Lys Ile Leu Val Pro Glu Gly Thr Arg Asp Val Pro Leu Gly Thr 
         275                280                285
Pro Leu Cys Ile Ile Val Glu Lys Glu Ala Asp Ile Ser Ala Phe Ala 
     290                295                300
Asp Tyr Arg Pro Thr Glu Val Thr Asp Leu Lys Pro Gln Ala Pro Pro 
 305                310                315                320
Pro Thr Pro Pro Pro Val Ala Ala Val Pro Pro Thr Pro Gln Pro Leu 
                 325                330                335
Ala Pro Thr Pro Ser Ala Pro Cys Pro Ala Thr Pro Ala Gly Pro Lys 
             340                345                350
Gly Arg Val Phe Val Ser Pro Leu Ala Lys Lys Leu Ala Val Glu Lys 
         355                360                365
Gly Ile Asp Leu Thr Gln Val Lys Gly Thr Gly Pro Asp Gly Arg Ile 
     370                375                380
Thr Lys Lys Asp Ile Asp Ser Phe Val Pro Ser Lys Val Ala Pro Ala 
 385                390                395                400
Pro Ala Ala Val Val Pro Pro Thr Gly Pro Gly Met Ala Pro Val Pro 
                 405                410                415
Thr Gly Val Phe Thr Asp Ile Pro Ile Ser Asn Ile Arg Arg Val Ile 
             420                425                430
Ala Gln Arg Leu Met Gln Ser Lys Gln Thr Ile Pro His Tyr Tyr Leu 
         435                440                445
Ser Ile Asp Val Asn Met Gly Glu Val Leu Leu Val Arg Lys Glu Leu 
     450                455                460
Asn Lys Ile Leu Glu Gly Arg Ser Lys Ile Ser Val Asn Asp Phe Ile 
 465                470                475                480
Ile Lys Ala Ser Ala Leu Ala Cys Leu Lys Val Pro Glu Ala Asn Ser 
                 485                490                495
Ser Trp Met Asp Thr Val Ile Arg Gln Asn His Val Val Asp Val Ser 
             500                505                510
Val Ala Val Ser Thr Pro Ala Gly Leu Ile Thr Pro Ile Val Phe Asn 
         515                520                525
Ala His Ile Lys Gly Val Glu Thr Ile Ala Asn Asp Val Val Ser Leu 
     530                535                540
Ala Thr Lys Ala Arg Glu Gly Lys Leu Gln Pro His Glu Phe Gln Gly 
 545                550                555                560
Gly Thr Phe Thr Ile Ser Asn Leu Gly Met Phe Gly Ile Lys Asn Phe 
                 565                570                575
Ser Ala Ile Ile Asn Pro Pro Gln Ala Cys Ile Leu Ala Ile Gly Ala 
             580                585                590
Ser Glu Asp Lys Leu Val Pro Ala Asp Asn Glu Lys Gly Phe Asp Val 
         595                600                605
Ala Ser Met Met Ser Val Thr Leu Ser Cys Asp His Arg Val Val Asp 
     610                615                620
Gly Ala Val Gly Ala Gln Trp Leu Ala Glu Phe Arg Lys Tyr Leu Glu 
 625                630                635                640
Lys Pro Ile Thr Met Leu Leu 
                 645



<210> 1521
<211> 3557
<212> DNA
<213> Rattus norvegicus
<308> D00189
<400> 1521

tctgtgccg  gggacccac  accgacaga  gcacgctcc  aacgcggcg  gcgtgcaga  60
gcccccagc  cgagcccgc  ctgagcccg  cctgcgcca  gctcacagc  tgtccgccg  120
cttcccgcg  agccgccaa  atgggggac  aaaaagatg  caagagctc  cccaagaag  180
gcaaggcca  agagcgccg  gacctggat  acctcaaga  ggaagtggc  atgacagag  240
acaagatgt  agtagaaga  gtctgccgg  aatacaata  cgactgcgt  cagggtctg  300
cacacagta  agcccagga  atcctagcc  gggatgggc  taacgccct  acaccaccg  360
ccaccaccc  agaatgggt  aagttctgc  gacagctat  tggtggctt  tccatcctg  420
tgtggatcg  ggcgatcct  tgcttcctg  cctatggca  ccaggcagg  actgaggat  480
acccttccg  tgacaatct  tacctgggc  tagtgctgg  cgctgtggt  atcatcacc  540
gctgcttct  ctactacca  gaagccaag  gctctaaga  tatggagtc  ttcaagaac  600
tggttcccc  gcaagccct  gtgatccgg  aaggtgaaa  gatgcaggt  aatgcggag  660
aggtggtgg  cggggacct  gtggagatc  agggtggcg  ccgggtgcc  gctgacctg  720
gcatcatct  ggcccatgg  tgcaaggtg  acaactctt  cctgactgg  gaatctgag  780
ctcagaccc  ctccccgga  tgcacacac  acaacccac  ggagacccg  aacatcacc  840
tcttttcca  caactgtgt  gaaggcacc  ctcgtggtg  ggtggtagc  acaggtgac  900
gcaccgtca  gggccgcat  gccaccctg  cctcaggcc  ggaggtggg  aagacgccc  960
tcgccattg  gatcgagca  ttcatccag  tcatcactg  cgtggccgt  ttcctgggc  1020
tctccttct  catcctctc  ctcattctg  gctacacct  gctggaggc  gtcatcttc  1080
tcatcggta  cattgtggc  aatgtccca  agggcctgc  ggctactgt  acggtgtgt  1140
tgacgctga  cgccaagcg  atggctcgg  agaactgtc  ggtaaagaa  ctggaggcg  1200
tggagacgc  aggctccac  tccaccatc  gctccgaca  gaccggcac  ctcacccag  1260
accgcatga  cgtcgccca  atgtggttt  acaaccaga  ccacgaggc  gacactact  1320
aggatcagt  agggacctc  ttcgacaag  gctcacaca  ctgggtggc  ctgtcccac  1380
tcgccggtc  ctgcaaccg  gctgtcttc  agggcgggc  ggataacat  cctgtactc  1440
agagggacg  ggcgggtga  gcctcagag  ccgccctgc  taagtgcat  gagctgtcc  1500
cgggttccg  aaagctgat  cgcgaacga  acaagaaag  ggccgagat  cccttcaac  1560
ccactaaca  ataccagct  tccatccat  agactgagg  ccccaatga  aaccgatac  1620
tgttagtga  gaagggcgc  cctgaacgc  ttctggacc  ctgtgcgac  atcctcctg  1680
agggcaagg  gcagcctct  gatgaggag  tgaaggagg  cttccagaa  gcctacctg  1740
agcttggtg  cctgggcga  cgtgtgctg  gtttctgcc  ttactacct  ccggaggaa  1800
agttcccca  gggctttgc  tttgactgt  atgacgtga  cttcaccac  gacaacctt  1860
gcttcgtgg  tctcatgtc  atgatcgac  ctccccggg  agctgtccc  gatgctgtg  1920
gcaaatgcc  cagtgcagg  atcaaggtc  tcatggtca  cggcgatca  cccatcact  1980
cgaaggcca  cgccaaagg  gtaggcatc  tctccgagg  taacgagac  gtggaggac  2040
tcgctgccc  gctcaacat  cctgtcagc  aggtcaacc  cagggatgc  aaagcctgt  2100
tgattcatg  caccgacct  aaggacttc  cctctgagc  gattgacga  atcctacag  2160
accacactg  gatcgtctt  gcccgaacc  cccctcagc  gaagctcat  atcgtggag  2220
gctgtcaga  acagggagc  attgtggct  tgactggcg  tggtgtgaa  gactcccct  2280
ctctgaaga  ggctgatat  ggggtggcc  tgggcattg  tggctctga  gtctctaag  2340
aggctgccg  catgattct  ctggatgac  attttgctt  cattgtcac  ggtgtggag  2400
aaggccgcc  gatctttga  aacctgaag  aatccatcg  ctacactct  accagcaac  2460
tccctgaga  cacaccctt  cttctcttc  tcatggcca  catcccact  ccccttggc  2520
ccatcacca  cctctgcat  gacctgggc  ccgacatgg  ccctgcaat  tccttggcc  2580
acgaggctg  agagagtga  atcatgaag  ggcagccca  gaacccacg  acagacaaa  2640
tggtcaacg  aaggctcat  agcatggcc  atgggcaga  cgggatgat  caggccctc  2700
gtggtttct  ctcctactt  gtcatcctg  cagaaaatg  tttcttgcc  ggtaacctg  2760
tgggcatcc  gctcaactg  gatgaccgc  ctgtcaacg  cctggaaga  agctacggg  2820
agcagtgga  ttatgagca  aggaaggtg  ttgagttca  gtgccacac  gccttcttc  2880
tgagcatag  ggtggtcca  tgggctgac  tgatcattt  caagaccag  aggaattcc  2940
tcttccagc  gggcatgaa  aataagatc  tgatcttcg  actgtttga  gaaacggcc  3000
tcgctgcct  cctgtccta  tgcccaggc  tggatgtgg  ccttcgcat  tacccgctc  3060
agcccagct  gtggttctg  gccttcccc  acagtttcc  catcttcgt  tatgatgag  3120
ttcgcaaac  catcctgcg  aggaacccc  ggggttggg  ggagaaaga  acctactat  3180
gacctcagc  accacgtcg  ccatgtctt  cctgccccc  agcccagga  agccctctc  3240
ggtccccca  tttgtactc  ggggggagg  gccttctct  cccgatggc  cccctctct  3300
cttgtggcc  agtctcctc  cccacacct  ggttacctc  cactttccc  catttctcc  3360
tctggctgg  ttctctccc  ccacagccc  tgcctctct  ctccttccc  tttctgtgt  3420
tctccccct  tctcccttg  agccctgcc  ctcattttc  ccctgggct  ctttttaca  3480
ccctgggcc  tgtctcctg  ctaatgcca  ctccggttc  aaatctgaa  aattatcaa  3540
tatatcagt  gggagag  3557



<210> 1522
<211> 1014
<212> PRT
<213> Rattus norvegicus
<308> D00189
<400> 1522

Met Gly Asp Lys Lys Asp Asp Lys Ser Ser Pro Lys Lys Ser Lys Ala 
  1               5                  10                  15
Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr 
             20                  25                  30
Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp 
         35                  40                  45
Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg 
     50                  55                  60
Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val 
 65                  70                  75                  80
Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile 
                 85                  90                  95
Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu 
             100                105                110
Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala 
         115                120                125
Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser 
     130                135                140
Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu 
 145                150                155                160
Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val 
                 165                170                175
Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp 
             180                185                190
Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu 
         195                200                205
Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp 
     210                215                220
Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val 
 225                230                235                240
Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val 
                 245                250                255
Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr 
             260                265                270
Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val 
         275                280                285
Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly 
     290                295                300
Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala 
 305                310                315                320
Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Leu 
                 325                330                335
Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu 
             340                345                350
Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr 
         355                360                365
Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp 
     370                375                380
Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser 
 385                390                395                400
Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly 
                 405                410                415
Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val 
             420                425                430
Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys 
         435                440                445
Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn 
     450                455                460
Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu 
 465                470                475                480
Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val 
                 485                490                495
Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ala Thr Ile Leu 
             500                505                510
Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe 
         515                520                525
Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly 
     530                535                540
Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala 
 545                550                555                560
Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val 
                 565                570                575
Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
             580                585                590
Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
         595                600                605
Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
     610                615                620
Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile 
 625                630                635                640
Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His 
                 645                650                655
Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu 
             660                665                670
Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
         675                680                685
Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val 
     690                695                700
Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
 705                710                715                720
Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala 
                 725                730                735
Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
             740                745                750
Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr 
         755                760                765
Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile 
     770                775                780
Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
 785                790                795                800
Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala 
                 805                810                815
Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp 
             820                825                830
Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly 
         835                840                845
Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala 
     850                855                860
Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp 
 865                870                875                880
Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
                 885                890                895
Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe 
             900                905                910
Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys 
         915                920                925
Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu 
     930                935                940
Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr 
 945                950                955                960
Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser 
                 965                970                975
Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp 
             980                985                990
Glu Ile Arg Lys Leu Ile Leu Arg Arg Asn Pro Gly Gly Trp Val Glu 
         995                1000                1005
Lys Glu Thr Tyr Tyr Ter 
     1010



<210> 1523
<211> 1013
<212> PRT
<213> Homo sapiens
<308> S00801
<400> 1523

Met Gly Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly 
  1               5                  10                  15
Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr 
             20                  25                  30
Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp 
         35                  40                  45
Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg 
     50                  55                  60
Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val 
 65                  70                  75                  80
Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile 
                 85                  90                  95
Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu 
             100                105                110
Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala 
         115                120                125
Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser 
     130                135                140
Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu 
 145                150                155                160
Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val 
                 165                170                175
Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp 
             180                185                190
Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu 
         195                200                205
Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp 
     210                215                220
Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val 
 225                230                235                240
Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val 
                 245                250                255
Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr 
             260                265                270
Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val 
         275                280                285
Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly 
     290                295                300
Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala 
 305                310                315                320
Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Val 
                 325                330                335
Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu 
             340                345                350
Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr 
         355                360                365
Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp 
     370                375                380
Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser 
 385                390                395                400
Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly 
                 405                410                415
Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val 
             420                425                430
Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys 
         435                440                445
Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn 
     450                455                460
Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu 
 465                470                475                480
Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val 
                 485                490                495
Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr Ile Leu 
             500                505                510
Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe 
         515                520                525
Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly 
     530                535                540
Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Tyr Pro Gln Gly Phe Ala 
 545                550                555                560
Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val 
                 565                570                575
Gly Leu Met Ser Met Ile Gly Pro Pro Arg Ala Ala Val Pro Asp Ala 
             580                585                590
Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
         595                600                605
Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
     610                615                620
Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile 
 625                630                635                640
Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His 
                 645                650                655
Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu 
             660                665                670
Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
         675                680                685
Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val 
     690                695                700
Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
 705                710                715                720
Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala 
                 725                730                735
Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
             740                745                750
Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr 
         755                760                765
Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile 
     770                775                780
Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
 785                790                795                800
Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala 
                 805                810                815
Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp 
             820                825                830
Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly 
         835                840                845
Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala 
     850                855                860
Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp 
 865                870                875                880
Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
                 885                890                895
Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe 
             900                905                910
Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys 
         915                920                925
Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu 
     930                935                940
Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr 
 945                950                955                960
Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser 
                 965                970                975
Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp 
             980                985                990
Glu Ile Arg Lys Leu Ile Leu Arg Arg Asn Pro Gly Gly Trp Val Glu 
         995                1000                1005
Lys Glu Thr Tyr Tyr 
     1010



<210> 1524
<211> 3557
<212> DNA
<213> Rattus norvegicus
<308> D00189
<400> 1524

tctgtgccg  gggacccac  accgacaga  gcacgctcc  aacgcggcg  gcgtgcaga  60
gcccccagc  cgagcccgc  ctgagcccg  cctgcgcca  gctcacagc  tgtccgccg  120
cttcccgcg  agccgccaa  atgggggac  aaaaagatg  caagagctc  cccaagaag  180
gcaaggcca  agagcgccg  gacctggat  acctcaaga  ggaagtggc  atgacagag  240
acaagatgt  agtagaaga  gtctgccgg  aatacaata  cgactgcgt  cagggtctg  300
cacacagta  agcccagga  atcctagcc  gggatgggc  taacgccct  acaccaccg  360
ccaccaccc  agaatgggt  aagttctgc  gacagctat  tggtggctt  tccatcctg  420
tgtggatcg  ggcgatcct  tgcttcctg  cctatggca  ccaggcagg  actgaggat  480
acccttccg  tgacaatct  tacctgggc  tagtgctgg  cgctgtggt  atcatcacc  540
gctgcttct  ctactacca  gaagccaag  gctctaaga  tatggagtc  ttcaagaac  600
tggttcccc  gcaagccct  gtgatccgg  aaggtgaaa  gatgcaggt  aatgcggag  660
aggtggtgg  cggggacct  gtggagatc  agggtggcg  ccgggtgcc  gctgacctg  720
gcatcatct  ggcccatgg  tgcaaggtg  acaactctt  cctgactgg  gaatctgag  780
ctcagaccc  ctccccgga  tgcacacac  acaacccac  ggagacccg  aacatcacc  840
tcttttcca  caactgtgt  gaaggcacc  ctcgtggtg  ggtggtagc  acaggtgac  900
gcaccgtca  gggccgcat  gccaccctg  cctcaggcc  ggaggtggg  aagacgccc  960
tcgccattg  gatcgagca  ttcatccag  tcatcactg  cgtggccgt  ttcctgggc  1020
tctccttct  catcctctc  ctcattctg  gctacacct  gctggaggc  gtcatcttc  1080
tcatcggta  cattgtggc  aatgtccca  agggcctgc  ggctactgt  acggtgtgt  1140
tgacgctga  cgccaagcg  atggctcgg  agaactgtc  ggtaaagaa  ctggaggcg  1200
tggagacgc  aggctccac  tccaccatc  gctccgaca  gaccggcac  ctcacccag  1260
accgcatga  cgtcgccca  atgtggttt  acaaccaga  ccacgaggc  gacactact  1320
aggatcagt  agggacctc  ttcgacaag  gctcacaca  ctgggtggc  ctgtcccac  1380
tcgccggtc  ctgcaaccg  gctgtcttc  agggcgggc  ggataacat  cctgtactc  1440
agagggacg  ggcgggtga  gcctcagag  ccgccctgc  taagtgcat  gagctgtcc  1500
cgggttccg  aaagctgat  cgcgaacga  acaagaaag  ggccgagat  cccttcaac  1560
ccactaaca  ataccagct  tccatccat  agactgagg  ccccaatga  aaccgatac  1620
tgttagtga  gaagggcgc  cctgaacgc  ttctggacc  ctgtgcgac  atcctcctg  1680
agggcaagg  gcagcctct  gatgaggag  tgaaggagg  cttccagaa  gcctacctg  1740
agcttggtg  cctgggcga  cgtgtgctg  gtttctgcc  ttactacct  ccggaggaa  1800
agttcccca  gggctttgc  tttgactgt  atgacgtga  cttcaccac  gacaacctt  1860
gcttcgtgg  tctcatgtc  atgatcgac  ctccccggg  agctgtccc  gatgctgtg  1920
gcaaatgcc  cagtgcagg  atcaaggtc  tcatggtca  cggcgatca  cccatcact  1980
cgaaggcca  cgccaaagg  gtaggcatc  tctccgagg  taacgagac  gtggaggac  2040
tcgctgccc  gctcaacat  cctgtcagc  aggtcaacc  cagggatgc  aaagcctgt  2100
tgattcatg  caccgacct  aaggacttc  cctctgagc  gattgacga  atcctacag  2160
accacactg  gatcgtctt  gcccgaacc  cccctcagc  gaagctcat  atcgtggag  2220
gctgtcaga  acagggagc  attgtggct  tgactggcg  tggtgtgaa  gactcccct  2280
ctctgaaga  ggctgatat  ggggtggcc  tgggcattg  tggctctga  gtctctaag  2340
aggctgccg  catgattct  ctggatgac  attttgctt  cattgtcac  ggtgtggag  2400
aaggccgcc  gatctttga  aacctgaag  aatccatcg  ctacactct  accagcaac  2460
tccctgaga  cacaccctt  cttctcttc  tcatggcca  catcccact  ccccttggc  2520
ccatcacca  cctctgcat  gacctgggc  ccgacatgg  ccctgcaat  tccttggcc  2580
acgaggctg  agagagtga  atcatgaag  ggcagccca  gaacccacg  acagacaaa  2640
tggtcaacg  aaggctcat  agcatggcc  atgggcaga  cgggatgat  caggccctc  2700
gtggtttct  ctcctactt  gtcatcctg  cagaaaatg  tttcttgcc  ggtaacctg  2760
tgggcatcc  gctcaactg  gatgaccgc  ctgtcaacg  cctggaaga  agctacggg  2820
agcagtgga  ttatgagca  aggaaggtg  ttgagttca  gtgccacac  gccttcttc  2880
tgagcatag  ggtggtcca  tgggctgac  tgatcattt  caagaccag  aggaattcc  2940
tcttccagc  gggcatgaa  aataagatc  tgatcttcg  actgtttga  gaaacggcc  3000
tcgctgcct  cctgtccta  tgcccaggc  tggatgtgg  ccttcgcat  tacccgctc  3060
agcccagct  gtggttctg  gccttcccc  acagtttcc  catcttcgt  tatgatgag  3120
ttcgcaaac  catcctgcg  aggaacccc  ggggttggg  ggagaaaga  acctactat  3180
gacctcagc  accacgtcg  ccatgtctt  cctgccccc  agcccagga  agccctctc  3240
ggtccccca  tttgtactc  ggggggagg  gccttctct  cccgatggc  cccctctct  3300
cttgtggcc  agtctcctc  cccacacct  ggttacctc  cactttccc  catttctcc  3360
tctggctgg  ttctctccc  ccacagccc  tgcctctct  ctccttccc  tttctgtgt  3420
tctccccct  tctcccttg  agccctgcc  ctcattttc  ccctgggct  ctttttaca  3480
ccctgggcc  tgtctcctg  ctaatgcca  ctccggttc  aaatctgaa  aattatcaa  3540
tatatcagt  gggagag  3557



<210> 1525
<211> 1014
<212> PRT
<213> Rattus norvegicus
<308> D00189
<400> 1525

Met Gly Asp Lys Lys Asp Asp Lys Ser Ser Pro Lys Lys Ser Lys Ala 
  1               5                  10                  15
Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr 
             20                  25                  30
Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp 
         35                  40                  45
Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg 
     50                  55                  60
Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val 
 65                  70                  75                  80
Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile 
                 85                  90                  95
Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu 
             100                105                110
Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala 
         115                120                125
Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser 
     130                135                140
Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu 
 145                150                155                160
Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val 
                 165                170                175
Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp 
             180                185                190
Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu 
         195                200                205
Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp 
     210                215                220
Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val 
 225                230                235                240
Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val 
                 245                250                255
Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr 
             260                265                270
Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val 
         275                280                285
Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly 
     290                295                300
Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala 
 305                310                315                320
Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Leu 
                 325                330                335
Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu 
             340                345                350
Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr 
         355                360                365
Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp 
     370                375                380
Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser 
 385                390                395                400
Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly 
                 405                410                415
Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val 
             420                425                430
Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys 
         435                440                445
Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn 
     450                455                460
Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu 
 465                470                475                480
Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val 
                 485                490                495
Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ala Thr Ile Leu 
             500                505                510
Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe 
         515                520                525
Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly 
     530                535                540
Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala 
 545                550                555                560
Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val 
                 565                570                575
Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
             580                585                590
Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
         595                600                605
Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
     610                615                620
Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile 
 625                630                635                640
Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His 
                 645                650                655
Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu 
             660                665                670
Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
         675                680                685
Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val 
     690                695                700
Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
 705                710                715                720
Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala 
                 725                730                735
Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
             740                745                750
Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr 
         755                760                765
Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile 
     770                775                780
Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
 785                790                795                800
Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala 
                 805                810                815
Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp 
             820                825                830
Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly 
         835                840                845
Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala 
     850                855                860
Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp 
 865                870                875                880
Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
                 885                890                895
Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe 
             900                905                910
Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys 
         915                920                925
Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu 
     930                935                940
Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr 
 945                950                955                960
Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser 
                 965                970                975
Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp 
             980                985                990
Glu Ile Arg Lys Leu Ile Leu Arg Arg Asn Pro Gly Gly Trp Val Glu 
         995                1000                1005
Lys Glu Thr Tyr Tyr Ter 
     1010



<210> 1526
<211> 1013
<212> PRT
<213> Homo sapiens
<308> S00801
<400> 1526

Met Gly Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly 
  1               5                  10                  15
Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr 
             20                  25                  30
Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp 
         35                  40                  45
Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg 
     50                  55                  60
Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val 
 65                  70                  75                  80
Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile 
                 85                  90                  95
Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu 
             100                105                110
Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala 
         115                120                125
Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser 
     130                135                140
Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu 
 145                150                155                160
Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val 
                 165                170                175
Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp 
             180                185                190
Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu 
         195                200                205
Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp 
     210                215                220
Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val 
 225                230                235                240
Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val 
                 245                250                255
Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr 
             260                265                270
Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val 
         275                280                285
Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly 
     290                295                300
Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala 
 305                310                315                320
Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Val 
                 325                330                335
Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu 
             340                345                350
Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr 
         355                360                365
Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp 
     370                375                380
Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser 
 385                390                395                400
Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly 
                 405                410                415
Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val 
             420                425                430
Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys 
         435                440                445
Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn 
     450                455                460
Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu 
 465                470                475                480
Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val 
                 485                490                495
Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr Ile Leu 
             500                505                510
Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe 
         515                520                525
Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly 
     530                535                540
Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Tyr Pro Gln Gly Phe Ala 
 545                550                555                560
Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val 
                 565                570                575
Gly Leu Met Ser Met Ile Gly Pro Pro Arg Ala Ala Val Pro Asp Ala 
             580                585                590
Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
         595                600                605
Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
     610                615                620
Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile 
 625                630                635                640
Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His 
                 645                650                655
Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu 
             660                665                670
Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
         675                680                685
Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val 
     690                695                700
Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
 705                710                715                720
Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala 
                 725                730                735
Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
             740                745                750
Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr 
         755                760                765
Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile 
     770                775                780
Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
 785                790                795                800
Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala 
                 805                810                815
Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp 
             820                825                830
Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly 
         835                840                845
Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala 
     850                855                860
Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp 
 865                870                875                880
Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
                 885                890                895
Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe 
             900                905                910
Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys 
         915                920                925
Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu 
     930                935                940
Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr 
 945                950                955                960
Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser 
                 965                970                975
Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp 
             980                985                990
Glu Ile Arg Lys Leu Ile Leu Arg Arg Asn Pro Gly Gly Trp Val Glu 
         995                1000                1005
Lys Glu Thr Tyr Tyr 
     1010



<210> 1527
<211> 1715
<212> DNA
<213> Rattus norvegicus
<308> D00512
<400> 1527

gacaagctt  tccggtctc  atggctgcc  tggcggttc  acacggcgt  gtccgcagg  60
ctctgctcc  cgggctgct  caggaagta  gatgcctgg  acgaagtta  gcatccaaa  120
ccactttga  tgatgtggt  atagtgagt  ctacacgaa  tcccattgg  tccttcctg  180
gcagccttg  ctctcagcc  gccaccaag  ttggtacta  tgcaattca  ggagccatt  240
aaaaggcag  gattccaaa  gaagaagtg  aggaggtct  catgggcaa  gtcatccaa  300
ggggagaag  acaggcccc  accaggcaa  ctacactgg  tgcaggtct  cccattgcc  360
ctccgtgca  cacagtaaa  aaggtgtgt  cctcaggaa  gaaagccat  atgatggcc  420
ctcaaagtc  tatgtgtgg  caccaggat  tgatggtgg  aggcggaat  gagaccatg  480
caaatgtcc  gtacgtaat  agcagagga  caacaccat  cggtggggt  aaacttgaa  540
acctgattg  gaaagacgg  ctaaccgat  tctacaata  aattcatat  ggcaattgt  600
ctgagaaca  cgcgaagaa  ctgagtatc  cgcgggagg  gcaggataa  tacgccatc  660
gctcttaca  ccgaagtaa  gaggcgtgg  atgcaggga  gtttgcaaa  gagattacg  720
ccatcacca  ctcagtgaa  ggtaaacca  acgtggtgg  gaaggaaga  gaagagtac  780
agcgagttg  cttcagtaa  gtgccaaag  tcaagacag  gttccagaa  gaaaacggc  840
cagtaacag  tgctaacgc  agcacactg  acgacggag  agctgctgt  gttctcatg  900
ctgcagagg  agcccagcg  ctcaaggtt  agccactgg  acgaatcgc  gcatttgct  960
atgctgctg  agaccccat  gatttccca  tcgcacctg  atatgctgt  cctaaggtt  1020
ttaaatatg  aggactgaa  aaagaagac  ttgccatgt  ggaagtaaa  gaagcattc  1080
gtgtggttg  actagccaa  attaaaatg  tggagattg  ccctcaaaa  gtaaatgtc  1140
atggaggag  tgtttctct  ggccatcca  tcgggatgt  tggagctcg  attgttgtt  1200
acttggctc  tgccttgaa  caaggagaa  tcggtctgg  tagtatttg  aatggagga  1260
gaggggctt  cgccgtgct  attgagaag  tgtagacat  ttgttttag  agacagttc  1320
acgtgaccc  ctgaagtga  ctacccctt  ggccagatt  tattcagga  aagctattt  1380
attttttat  attttctac  aaaaatttt  aaaaatcac  tccaaaaac  cattgaaat  1440
gcaaataaa  atttctcct  ctttaatat  ttgtaaaca  tcggatact  tactattga  1500
atatactgt  ggtactaga  gcatggctc  gccgttaag  gcacttgtt  ctacctgtg  1560
ggtgcatgg  tttaatccc  gcacttgga  acagaggca  gtgcatctt  ctgagttaa  1620
gttagcctg  tccacagag  tagtgccct  acagccaag  ctacacaga  tagtagaaa  1680
tctggggga  aaaaaaaaa  caaataaaa  aaaaa  1715



<210> 1528
<211> 424
<212> PRT
<213> Rattus norvegicus
<308> BAA00401
<400> 1528

Met Ala Ala Leu Ala Val Leu His Gly Val Val Arg Arg Pro Leu Leu 
  1               5                  10                  15
Arg Gly Leu Leu Gln Glu Val Arg Cys Leu Gly Arg Ser Tyr Ala Ser 
             20                  25                  30
Lys Pro Thr Leu Asn Asp Val Val Ile Val Ser Ala Thr Arg Thr Pro 
         35                  40                  45
Ile Gly Ser Phe Leu Gly Ser Leu Ala Ser Gln Pro Ala Thr Lys Leu 
     50                  55                  60
Gly Thr Ile Ala Ile Gln Gly Ala Ile Glu Lys Ala Gly Ile Pro Lys 
 65                  70                  75                  80
Glu Glu Val Lys Glu Val Tyr Met Gly Asn Val Ile Gln Gly Gly Glu 
                 85                  90                  95
Gly Gln Ala Pro Thr Arg Gln Ala Thr Leu Gly Ala Gly Leu Pro Ile 
             100                105                110
Ala Thr Pro Cys Thr Thr Val Asn Lys Val Cys Ala Ser Gly Met Lys 
         115                120                125
Ala Ile Met Met Ala Ser Gln Ser Leu Met Cys Gly His Gln Asp Val 
     130                135                140
Met Val Ala Gly Gly Met Glu Ser Met Ser Asn Val Pro Tyr Val Met 
 145                150                155                160
Ser Arg Gly Ala Thr Pro Tyr Gly Gly Val Lys Leu Glu Asp Leu Ile 
                 165                170                175
Val Lys Asp Gly Leu Thr Asp Val Tyr Asn Lys Ile His Met Gly Asn 
             180                185                190
Cys Ala Glu Asn Thr Ala Lys Lys Leu Ser Ile Ser Arg Glu Glu Gln 
         195                200                205
Asp Lys Tyr Ala Ile Gly Ser Tyr Thr Arg Ser Lys Glu Ala Trp Asp 
     210                215                220
Ala Gly Lys Phe Ala Asn Glu Ile Thr Pro Ile Thr Ile Ser Val Lys 
 225                230                235                240
Gly Lys Pro Asp Val Val Val Lys Glu Asp Glu Glu Tyr Lys Arg Val 
                 245                250                255
Asp Phe Ser Lys Val Pro Lys Leu Lys Thr Val Phe Gln Lys Glu Asn 
             260                265                270
Gly Thr Val Thr Ala Ala Asn Ala Ser Thr Leu Asn Asp Gly Ala Ala 
         275                280                285
Ala Val Val Leu Met Thr Ala Glu Ala Ala Gln Arg Leu Lys Val Lys 
     290                295                300
Pro Leu Ala Arg Ile Ala Ala Phe Ala Asp Ala Ala Val Asp Pro Ile 
 305                310                315                320
Asp Phe Pro Leu Ala Pro Ala Tyr Ala Val Pro Lys Val Leu Lys Tyr 
                 325                330                335
Ala Gly Leu Lys Lys Glu Asp Ile Ala Met Trp Glu Val Asn Glu Ala 
             340                345                350
Phe Ser Val Val Val Leu Ala Asn Ile Lys Met Leu Glu Ile Asp Pro 
         355                360                365
Gln Lys Val Asn Val His Gly Gly Ala Val Ser Leu Gly His Pro Ile 
     370                375                380
Gly Met Ser Gly Ala Arg Ile Val Val His Leu Ala His Ala Leu Lys 
 385                390                395                400
Gln Gly Glu Phe Gly Leu Ala Ser Ile Cys Asn Gly Gly Gly Gly Ala 
                 405                410                415
Ser Ala Val Leu Ile Glu Lys Leu 
             420



<210> 1529
<211> 1518
<212> DNA
<213> Homo sapiens
<308> NM_000019
<400> 1529

aggccgcta  ggtgcgggg  tggggagga  gccgctagt  tacgcctgt  gagccgata  60
tcagccctc  gcgaccatg  ctgtgctgg  ggcacttct  cgcagcggc  cccgcagcc  120
cagccccct  ctccggagg  tggtgcagg  aataagata  gtggaacgg  gttatgtat  180
aaaacccac  ttgaaggaa  tggtcatag  aagtgctac  agaacaccc  ttggatctt  240
tttaggcag  ctttccttg  tgccagcca  taagcttgg  tccattgca  ttcagggag  300
cattgaaaa  gcagggatt  caaaagaag  agtgaaaga  gcatacatg  gtaatgttc  360
acaaggagg  gaaggacaa  ctcctacaa  gcaggcagt  ttgggtgca  gcttaccta  420
ttctactcc  tgtaccacc  taaacaaag  ttgtgcttc  ggaatgaaa  ccatcatga  480
ggcctctca  agtcttatg  gtggacatc  ggatgtgat  gtggcaggt  ggatggaga  540
catgtccaa  gttccatat  taatgaaca  aggatcaac  ccatatggt  gggtaaagc  600
tgaagattt  attgtaaaa  acgggctaa  tgatgtcta  aataaaatt  atatgggca  660
ctgtgctga  aatacagca  agaagctga  tattgcacg  aatgaacag  acgcttatg  720
tattaattc  tataccaga  gtaaagcag  atgggaagc  gggaaattt  gaaatgaag  780
tattcctgt  acagttaca  taaaaggtc  accagatgt  gtggtgaaa  aagatgaag  840
atataaacg  gttgatttt  gcaaagttc  aaagctgaa  acagttttc  agaaagaaa  900
tggcacagt  acagctgcc  atgccagta  actgaatga  ggagcagct  ctctggttc  960
catgacggc  gatgcagcg  agaggctca  tgttacacc  ctggcaaga  tagtagcat  1020
tgctgacgc  gctgtagaa  ctattgatt  tccaattgc  cctgtatat  ctgcatcta  1080
ggttcttaa  gatgtggga  tgaaaaaag  agatattgc  atgtgggaa  taaatgaag  1140
ctttagtct  gttgtacta  caaacatta  aatgttgga  attgatccc  aaaaagtga  1200
tatcaatgg  ggagctgtt  ctctgggac  tccaattgg  atgtctgga  ccaggattg  1260
tggtcattt  actcatgcc  tgaagcaag  agaatacgg  cttgccagt  tttgcaatg  1320
aggaggagg  gcttctgcc  tgctaattc  gaagctgta  acaacctct  ctatttaag  1380
agacaaccc  atgtgacca  aaggcctgc  gtaatcagt  tgactactg  gggtcagct  1440
atattcaga  aagctgttt  attttttat  attttctat  ttaactttt  aaaatcaaa  1500
tgatgaaat  ccaaaaca  1518



<210> 1530
<211> 427
<212> PRT
<213> Homo sapiens
<308> P24752
<400> 1530

Met Ala Val Leu Ala Ala Leu Leu Arg Ser Gly Ala Arg Ser Arg Ser 
  1               5                  10                  15
Pro Leu Leu Arg Arg Leu Val Gln Glu Ile Arg Tyr Val Glu Arg Ser 
             20                  25                  30
Tyr Val Ser Lys Pro Thr Leu Lys Glu Val Val Ile Val Ser Ala Thr 
         35                  40                  45
Arg Thr Pro Ile Gly Ser Phe Leu Gly Ser Leu Ser Leu Leu Pro Ala 
     50                  55                  60
Thr Lys Leu Gly Ser Ile Ala Ile Gln Gly Ala Ile Glu Lys Ala Gly 
 65                  70                  75                  80
Ile Pro Lys Glu Glu Val Lys Glu Ala Tyr Met Gly Asn Val Leu Gln 
                 85                  90                  95
Gly Gly Glu Gly Gln Ala Pro Thr Arg Gln Ala Val Leu Gly Ala Gly 
             100                105                110
Leu Pro Ile Ser Thr Pro Cys Thr Thr Ile Asn Lys Val Cys Ala Ser 
         115                120                125
Gly Met Lys Ala Ile Met Met Ala Ser Gln Ser Leu Met Cys Gly His 
     130                135                140
Gln Asp Val Met Val Ala Gly Gly Met Glu Ser Met Ser Asn Val Pro 
 145                150                155                160
Tyr Val Met Asn Arg Gly Ser Thr Pro Tyr Gly Gly Val Lys Leu Glu 
                 165                170                175
Asp Leu Ile Val Lys Asp Gly Leu Thr Asp Val Tyr Asn Lys Ile His 
             180                185                190
Met Gly Ser Cys Ala Glu Asn Thr Ala Lys Lys Leu Asn Ile Ala Arg 
         195                200                205
Asn Glu Gln Asp Ala Tyr Ala Ile Asn Ser Tyr Thr Arg Ser Lys Ala 
     210                215                220
Ala Trp Glu Ala Gly Lys Phe Gly Asn Glu Val Ile Pro Val Thr Val 
 225                230                235                240
Thr Val Lys Gly Gln Pro Asp Val Val Val Lys Glu Asp Glu Glu Tyr 
                 245                250                255
Lys Arg Val Asp Phe Ser Lys Val Pro Lys Leu Lys Thr Val Phe Gln 
             260                265                270
Lys Glu Asn Gly Thr Val Thr Ala Ala Asn Ala Ser Thr Leu Asn Asp 
         275                280                285
Gly Ala Ala Ala Leu Val Leu Met Thr Ala Asp Ala Ala Lys Arg Leu 
     290                295                300
Asn Val Thr Pro Leu Ala Arg Ile Val Ala Phe Ala Asp Ala Ala Val 
 305                310                315                320
Glu Pro Ile Asp Phe Pro Ile Ala Pro Val Tyr Ala Ala Ser Met Val 
                 325                330                335
Leu Lys Asp Val Gly Leu Lys Lys Glu Asp Ile Ala Met Trp Glu Val 
             340                345                350
Asn Glu Ala Phe Ser Leu Val Val Leu Ala Asn Ile Lys Met Leu Glu 
         355                360                365
Ile Asp Pro Gln Lys Val Asn Ile Asn Gly Gly Ala Val Ser Leu Gly 
     370                375                380
His Pro Ile Gly Met Ser Gly Ala Arg Ile Val Gly His Leu Thr His 
 385                390                395                400
Ala Leu Lys Gln Gly Glu Tyr Gly Leu Ala Ser Ile Cys Asn Gly Gly 
                 405                410                415
Gly Gly Ala Ser Ala Met Leu Ile Gln Lys Leu 
             420                425



<210> 1531
<211> 1715
<212> DNA
<213> Rattus norvegicus
<308> D00512
<400> 1531

gacaagctt  tccggtctc  atggctgcc  tggcggttc  acacggcgt  gtccgcagg  60
ctctgctcc  cgggctgct  caggaagta  gatgcctgg  acgaagtta  gcatccaaa  120
ccactttga  tgatgtggt  atagtgagt  ctacacgaa  tcccattgg  tccttcctg  180
gcagccttg  ctctcagcc  gccaccaag  ttggtacta  tgcaattca  ggagccatt  240
aaaaggcag  gattccaaa  gaagaagtg  aggaggtct  catgggcaa  gtcatccaa  300
ggggagaag  acaggcccc  accaggcaa  ctacactgg  tgcaggtct  cccattgcc  360
ctccgtgca  cacagtaaa  aaggtgtgt  cctcaggaa  gaaagccat  atgatggcc  420
ctcaaagtc  tatgtgtgg  caccaggat  tgatggtgg  aggcggaat  gagaccatg  480
caaatgtcc  gtacgtaat  agcagagga  caacaccat  cggtggggt  aaacttgaa  540
acctgattg  gaaagacgg  ctaaccgat  tctacaata  aattcatat  ggcaattgt  600
ctgagaaca  cgcgaagaa  ctgagtatc  cgcgggagg  gcaggataa  tacgccatc  660
gctcttaca  ccgaagtaa  gaggcgtgg  atgcaggga  gtttgcaaa  gagattacg  720
ccatcacca  ctcagtgaa  ggtaaacca  acgtggtgg  gaaggaaga  gaagagtac  780
agcgagttg  cttcagtaa  gtgccaaag  tcaagacag  gttccagaa  gaaaacggc  840
cagtaacag  tgctaacgc  agcacactg  acgacggag  agctgctgt  gttctcatg  900
ctgcagagg  agcccagcg  ctcaaggtt  agccactgg  acgaatcgc  gcatttgct  960
atgctgctg  agaccccat  gatttccca  tcgcacctg  atatgctgt  cctaaggtt  1020
ttaaatatg  aggactgaa  aaagaagac  ttgccatgt  ggaagtaaa  gaagcattc  1080
gtgtggttg  actagccaa  attaaaatg  tggagattg  ccctcaaaa  gtaaatgtc  1140
atggaggag  tgtttctct  ggccatcca  tcgggatgt  tggagctcg  attgttgtt  1200
acttggctc  tgccttgaa  caaggagaa  tcggtctgg  tagtatttg  aatggagga  1260
gaggggctt  cgccgtgct  attgagaag  tgtagacat  ttgttttag  agacagttc  1320
acgtgaccc  ctgaagtga  ctacccctt  ggccagatt  tattcagga  aagctattt  1380
attttttat  attttctac  aaaaatttt  aaaaatcac  tccaaaaac  cattgaaat  1440
gcaaataaa  atttctcct  ctttaatat  ttgtaaaca  tcggatact  tactattga  1500
atatactgt  ggtactaga  gcatggctc  gccgttaag  gcacttgtt  ctacctgtg  1560
ggtgcatgg  tttaatccc  gcacttgga  acagaggca  gtgcatctt  ctgagttaa  1620
gttagcctg  tccacagag  tagtgccct  acagccaag  ctacacaga  tagtagaaa  1680
tctggggga  aaaaaaaaa  caaataaaa  aaaaa  1715



<210> 1532
<211> 424
<212> PRT
<213> Rattus norvegicus
<308> BAA00401
<400> 1532

Met Ala Ala Leu Ala Val Leu His Gly Val Val Arg Arg Pro Leu Leu 
  1               5                  10                  15
Arg Gly Leu Leu Gln Glu Val Arg Cys Leu Gly Arg Ser Tyr Ala Ser 
             20                  25                  30
Lys Pro Thr Leu Asn Asp Val Val Ile Val Ser Ala Thr Arg Thr Pro 
         35                  40                  45
Ile Gly Ser Phe Leu Gly Ser Leu Ala Ser Gln Pro Ala Thr Lys Leu 
     50                  55                  60
Gly Thr Ile Ala Ile Gln Gly Ala Ile Glu Lys Ala Gly Ile Pro Lys 
 65                  70                  75                  80
Glu Glu Val Lys Glu Val Tyr Met Gly Asn Val Ile Gln Gly Gly Glu 
                 85                  90                  95
Gly Gln Ala Pro Thr Arg Gln Ala Thr Leu Gly Ala Gly Leu Pro Ile 
             100                105                110
Ala Thr Pro Cys Thr Thr Val Asn Lys Val Cys Ala Ser Gly Met Lys 
         115                120                125
Ala Ile Met Met Ala Ser Gln Ser Leu Met Cys Gly His Gln Asp Val 
     130                135                140
Met Val Ala Gly Gly Met Glu Ser Met Ser Asn Val Pro Tyr Val Met 
 145                150                155                160
Ser Arg Gly Ala Thr Pro Tyr Gly Gly Val Lys Leu Glu Asp Leu Ile 
                 165                170                175
Val Lys Asp Gly Leu Thr Asp Val Tyr Asn Lys Ile His Met Gly Asn 
             180                185                190
Cys Ala Glu Asn Thr Ala Lys Lys Leu Ser Ile Ser Arg Glu Glu Gln 
         195                200                205
Asp Lys Tyr Ala Ile Gly Ser Tyr Thr Arg Ser Lys Glu Ala Trp Asp 
     210                215                220
Ala Gly Lys Phe Ala Asn Glu Ile Thr Pro Ile Thr Ile Ser Val Lys 
 225                230                235                240
Gly Lys Pro Asp Val Val Val Lys Glu Asp Glu Glu Tyr Lys Arg Val 
                 245                250                255
Asp Phe Ser Lys Val Pro Lys Leu Lys Thr Val Phe Gln Lys Glu Asn 
             260                265                270
Gly Thr Val Thr Ala Ala Asn Ala Ser Thr Leu Asn Asp Gly Ala Ala 
         275                280                285
Ala Val Val Leu Met Thr Ala Glu Ala Ala Gln Arg Leu Lys Val Lys 
     290                295                300
Pro Leu Ala Arg Ile Ala Ala Phe Ala Asp Ala Ala Val Asp Pro Ile 
 305                310                315                320
Asp Phe Pro Leu Ala Pro Ala Tyr Ala Val Pro Lys Val Leu Lys Tyr 
                 325                330                335
Ala Gly Leu Lys Lys Glu Asp Ile Ala Met Trp Glu Val Asn Glu Ala 
             340                345                350
Phe Ser Val Val Val Leu Ala Asn Ile Lys Met Leu Glu Ile Asp Pro 
         355                360                365
Gln Lys Val Asn Val His Gly Gly Ala Val Ser Leu Gly His Pro Ile 
     370                375                380
Gly Met Ser Gly Ala Arg Ile Val Val His Leu Ala His Ala Leu Lys 
 385                390                395                400
Gln Gly Glu Phe Gly Leu Ala Ser Ile Cys Asn Gly Gly Gly Gly Ala 
                 405                410                415
Ser Ala Val Leu Ile Glu Lys Leu 
             420



<210> 1533
<211> 1518
<212> DNA
<213> Homo sapiens
<308> NM_000019
<400> 1533

aggccgcta  ggtgcgggg  tggggagga  gccgctagt  tacgcctgt  gagccgata  60
tcagccctc  gcgaccatg  ctgtgctgg  ggcacttct  cgcagcggc  cccgcagcc  120
cagccccct  ctccggagg  tggtgcagg  aataagata  gtggaacgg  gttatgtat  180
aaaacccac  ttgaaggaa  tggtcatag  aagtgctac  agaacaccc  ttggatctt  240
tttaggcag  ctttccttg  tgccagcca  taagcttgg  tccattgca  ttcagggag  300
cattgaaaa  gcagggatt  caaaagaag  agtgaaaga  gcatacatg  gtaatgttc  360
acaaggagg  gaaggacaa  ctcctacaa  gcaggcagt  ttgggtgca  gcttaccta  420
ttctactcc  tgtaccacc  taaacaaag  ttgtgcttc  ggaatgaaa  ccatcatga  480
ggcctctca  agtcttatg  gtggacatc  ggatgtgat  gtggcaggt  ggatggaga  540
catgtccaa  gttccatat  taatgaaca  aggatcaac  ccatatggt  gggtaaagc  600
tgaagattt  attgtaaaa  acgggctaa  tgatgtcta  aataaaatt  atatgggca  660
ctgtgctga  aatacagca  agaagctga  tattgcacg  aatgaacag  acgcttatg  720
tattaattc  tataccaga  gtaaagcag  atgggaagc  gggaaattt  gaaatgaag  780
tattcctgt  acagttaca  taaaaggtc  accagatgt  gtggtgaaa  aagatgaag  840
atataaacg  gttgatttt  gcaaagttc  aaagctgaa  acagttttc  agaaagaaa  900
tggcacagt  acagctgcc  atgccagta  actgaatga  ggagcagct  ctctggttc  960
catgacggc  gatgcagcg  agaggctca  tgttacacc  ctggcaaga  tagtagcat  1020
tgctgacgc  gctgtagaa  ctattgatt  tccaattgc  cctgtatat  ctgcatcta  1080
ggttcttaa  gatgtggga  tgaaaaaag  agatattgc  atgtgggaa  taaatgaag  1140
ctttagtct  gttgtacta  caaacatta  aatgttgga  attgatccc  aaaaagtga  1200
tatcaatgg  ggagctgtt  ctctgggac  tccaattgg  atgtctgga  ccaggattg  1260
tggtcattt  actcatgcc  tgaagcaag  agaatacgg  cttgccagt  tttgcaatg  1320
aggaggagg  gcttctgcc  tgctaattc  gaagctgta  acaacctct  ctatttaag  1380
agacaaccc  atgtgacca  aaggcctgc  gtaatcagt  tgactactg  gggtcagct  1440
atattcaga  aagctgttt  attttttat  attttctat  ttaactttt  aaaatcaaa  1500
tgatgaaat  ccaaaaca  1518



<210> 1534
<211> 427
<212> PRT
<213> Homo sapiens
<308> P24752
<400> 1534

Met Ala Val Leu Ala Ala Leu Leu Arg Ser Gly Ala Arg Ser Arg Ser 
  1               5                  10                  15
Pro Leu Leu Arg Arg Leu Val Gln Glu Ile Arg Tyr Val Glu Arg Ser 
             20                  25                  30
Tyr Val Ser Lys Pro Thr Leu Lys Glu Val Val Ile Val Ser Ala Thr 
         35                  40                  45
Arg Thr Pro Ile Gly Ser Phe Leu Gly Ser Leu Ser Leu Leu Pro Ala 
     50                  55                  60
Thr Lys Leu Gly Ser Ile Ala Ile Gln Gly Ala Ile Glu Lys Ala Gly 
 65                  70                  75                  80
Ile Pro Lys Glu Glu Val Lys Glu Ala Tyr Met Gly Asn Val Leu Gln 
                 85                  90                  95
Gly Gly Glu Gly Gln Ala Pro Thr Arg Gln Ala Val Leu Gly Ala Gly 
             100                105                110
Leu Pro Ile Ser Thr Pro Cys Thr Thr Ile Asn Lys Val Cys Ala Ser 
         115                120                125
Gly Met Lys Ala Ile Met Met Ala Ser Gln Ser Leu Met Cys Gly His 
     130                135                140
Gln Asp Val Met Val Ala Gly Gly Met Glu Ser Met Ser Asn Val Pro 
 145                150                155                160
Tyr Val Met Asn Arg Gly Ser Thr Pro Tyr Gly Gly Val Lys Leu Glu 
                 165                170                175
Asp Leu Ile Val Lys Asp Gly Leu Thr Asp Val Tyr Asn Lys Ile His 
             180                185                190
Met Gly Ser Cys Ala Glu Asn Thr Ala Lys Lys Leu Asn Ile Ala Arg 
         195                200                205
Asn Glu Gln Asp Ala Tyr Ala Ile Asn Ser Tyr Thr Arg Ser Lys Ala 
     210                215                220
Ala Trp Glu Ala Gly Lys Phe Gly Asn Glu Val Ile Pro Val Thr Val 
 225                230                235                240
Thr Val Lys Gly Gln Pro Asp Val Val Val Lys Glu Asp Glu Glu Tyr 
                 245                250                255
Lys Arg Val Asp Phe Ser Lys Val Pro Lys Leu Lys Thr Val Phe Gln 
             260                265                270
Lys Glu Asn Gly Thr Val Thr Ala Ala Asn Ala Ser Thr Leu Asn Asp 
         275                280                285
Gly Ala Ala Ala Leu Val Leu Met Thr Ala Asp Ala Ala Lys Arg Leu 
     290                295                300
Asn Val Thr Pro Leu Ala Arg Ile Val Ala Phe Ala Asp Ala Ala Val 
 305                310                315                320
Glu Pro Ile Asp Phe Pro Ile Ala Pro Val Tyr Ala Ala Ser Met Val 
                 325                330                335
Leu Lys Asp Val Gly Leu Lys Lys Glu Asp Ile Ala Met Trp Glu Val 
             340                345                350
Asn Glu Ala Phe Ser Leu Val Val Leu Ala Asn Ile Lys Met Leu Glu 
         355                360                365
Ile Asp Pro Gln Lys Val Asn Ile Asn Gly Gly Ala Val Ser Leu Gly 
     370                375                380
His Pro Ile Gly Met Ser Gly Ala Arg Ile Val Gly His Leu Thr His 
 385                390                395                400
Ala Leu Lys Gln Gly Glu Tyr Gly Leu Ala Ser Ile Cys Asn Gly Gly 
                 405                410                415
Gly Gly Ala Ser Ala Met Leu Ile Gln Lys Leu 
             420                425



<210> 1535
<211> 1109
<212> DNA
<213> Rattus norvegicus
<308> D00569
<400> 1535

gaattccct  ctgcaaaca  ggcgctgct  gcccgtgcg  tctttgctg  ggtgtcccg  60
ctcccctgc  atcccggtc  tcagaagtt  ttcagcttt  gaacgaaaa  cctgtatca  120
agcatcgat  ctccacagt  taaattctt  ccacccatt  taaagccta  gctaccacc  180
aatgccttt  aaggaaaag  ggctttcat  acgggagga  gcactggcc  tggcaaggc  240
atgacaact  tccgctcca  cctgggtgc  cagtgtgtg  tcgcgagca  gaatattga  300
gttctgaaa  ctactgcag  agagattac  tctaaaact  gaaataagg  ctatgcgat  360
cggtgtgac  ttcgagatc  tgatatggt  cacaacaca  tactggagc  gatcaaagt  420
gcagggcat  ctgatgtgg  gataaacaa  gcggcaggg  acttcattt  tcccagtga  480
agactgtct  ccaatggtt  gaggaccat  actgacata  ttctcaatg  tacagccta  540
gtgacgata  aaattggaa  gcagctaat  aaagcacag  aaggagtcg  ctttcttgc  600
atcactacg  tctatgctg  gagcggatc  ggctttgta  tgccaagtt  ttcagccaa  660
tcaggcgtg  aagccatga  taagtctct  gcagctgaa  ggggtagat  cggaatgcg  720
ttcaacata  ttcagccag  gcctatcaa  accaaaggt  cctttagcc  tttggaccc  780
actggaaaa  ttgagaaag  tatgatcga  agaatcccc  gtggtcggc  gggaactgt  840
gaggaactt  ccaatctag  gactttcct  tgcagtgat  atgcctctt  gatcaatgg  900
gcagtcatt  gatttgacg  tggagagga  gtgtttctg  caggtgaat  caactctct  960
aagaaggtc  ccaaggagg  gtgggatgt  atcgaaggc  tcatcagaa  gacaaaagg  1020
tcctaagac  ttcatggct  cctctgtga  aaactaaag  ttagggact  tatagatgg  1080
catttgagt  aataaattt  ttgtctgat  1109



<210> 1536
<211> 335
<212> PRT
<213> Rattus norvegicus
<308> Q64591
<400> 1536

Met Ala Leu Leu Ala Arg Ala Phe Phe Ala Gly Val Ser Arg Leu Pro 
  1               5                  10                  15
Cys Asp Pro Gly Pro Gln Lys Phe Phe Ser Phe Gly Thr Lys Thr Leu 
             20                  25                  30
Tyr Gln Ser Ile Asp Ala Pro Gln Ser Lys Phe Phe Pro Pro Ile Leu 
         35                  40                  45
Lys Pro Met Leu Pro Pro Asn Ala Phe Gln Gly Lys Val Ala Phe Ile 
     50                  55                  60
Thr Gly Gly Gly Thr Gly Leu Gly Lys Ala Met Thr Thr Phe Arg Ser 
 65                  70                  75                  80
Ser Leu Gly Ala Gln Cys Val Ile Ala Ser Arg Asn Ile Asp Val Leu 
                 85                  90                  95
Lys Ala Thr Ala Glu Glu Ile Thr Ser Lys Thr Gly Asn Lys Val Tyr 
             100                105                110
Ala Ile Arg Cys Asp Val Arg Asp Pro Asp Met Val His Asn Thr Val 
         115                120                125
Leu Glu Leu Ile Lys Val Ala Gly His Pro Asp Val Val Ile Asn Asn 
     130                135                140
Ala Ala Gly Asn Phe Ile Ser Pro Ser Glu Arg Leu Ser Pro Asn Gly 
 145                150                155                160
Trp Arg Thr Ile Thr Asp Ile Val Leu Asn Gly Thr Ala Tyr Val Thr 
                 165                170                175
Ile Glu Ile Gly Lys Gln Leu Ile Lys Ala Gln Lys Gly Val Ala Phe 
             180                185                190
Leu Ala Ile Thr Thr Ile Tyr Ala Glu Ser Gly Ser Gly Phe Val Met 
         195                200                205
Pro Ser Ser Ser Ala Lys Ser Gly Val Glu Ala Met Asn Lys Ser Leu 
     210                215                220
Ala Ala Glu Trp Gly Arg Tyr Gly Met Arg Phe Asn Ile Ile Gln Pro 
 225                230                235                240
Gly Pro Ile Lys Thr Lys Gly Ala Phe Ser Arg Leu Asp Pro Thr Gly 
                 245                250                255
Lys Phe Glu Lys Asp Met Ile Glu Arg Ile Pro Cys Gly Arg Leu Gly 
             260                265                270
Thr Val Glu Glu Leu Ala Asn Leu Ala Thr Phe Leu Cys Ser Asp Tyr 
         275                280                285
Ala Ser Trp Ile Asn Gly Ala Val Ile Arg Phe Asp Gly Gly Glu Glu 
     290                295                300
Val Phe Leu Ser Gly Glu Phe Asn Ser Leu Lys Lys Val Thr Lys Glu 
 305                310                315                320
Glu Trp Asp Val Ile Glu Gly Leu Ile Arg Lys Thr Lys Gly Ser 
                 325                330                335



<210> 1537
<211> 1120
<212> DNA
<213> Homo sapiens
<308> L26050
<400> 1537

gagactcaa  atgaagcta  cggccaggg  tttctttac  ctggggtcc  ggctgccct  60
tggcctcgc  cctcggagg  ttttcagtt  tgggacaaa  atattatat  aaaacactg  120
agctttgca  tctaaattc  tttcacctc  tcaaaaagc  atgctacca  ctaatagtt  180
tcaaggaaa  gtggcattc  ttactgggg  aggtactgg  cttggtaaa  gaatgacaa  240
tcttctgtc  agcctaggt  ctcagtgcg  gatagccag  cggaagatg  atgttttga  300
agctaccgc  gaacaaatt  cttctcaaa  tggaaataa  gttcatgca  ttcagtgtg  360
tgtgaggga  cctgatatg  ttcaaaaca  tgtgtcaga  ctgatcaaa  ttgcaggac  420
tcctaatat  gtgataaac  atgcagcag  gaattttat  tctcctact  aaagacttt  480
tcctaatgc  tggaaaacc  taactgaca  agttctaaa  ggcacagcc  tcgtgacac  540
agaaattgg  aaacaacta  ttaaagcac  gaaaggagc  gcatttctt  ctattacta  600
tatctatgc  gagactggt  caggttttg  agtaccaag  gcttctgcc  aagcaggtg  660
ggaagccat  agcaagtct  ttgcagctg  atggggtaa  tatggaatg  gattcaatg  720
gattcaacc  gggcctata  aaaccaaag  tgcctttag  cgtctggac  caactggaa  780
atttgagaa  gaaatgatt  gcagaattc  ctgtggtcg  ctggggact  tagaagaac  840
cgcaaatct  gctgctttc  tttgtagtg  ttatgcttc  tggattaat  gagcagtca  900
taaatttga  ggtggagag  aagtactta  ttcagggga  ttcaacgac  tgagaaagg  960
caccaagga  cagtgggac  ccatagaag  actcatcag  aagacaaaa  gttcctaag  1020
ccactttgg  cttcatctt  gttacagaa  agggaatag  aatgaaaca  attatctct  1080
atcttttga  tatttcaag  ctaataaat  cttaattaac  1120



<210> 1538
<211> 335
<212> PRT
<213> Homo sapiens
<308> Q16698
<400> 1538

Met Lys Leu Pro Ala Arg Val Phe Phe Thr Leu Gly Ser Arg Leu Pro 
  1               5                  10                  15
Cys Gly Leu Ala Pro Arg Arg Phe Phe Ser Tyr Gly Thr Lys Ile Leu 
             20                  25                  30
Tyr Gln Asn Thr Glu Ala Leu Gln Ser Lys Phe Phe Ser Pro Leu Gln 
         35                  40                  45
Lys Ala Met Leu Pro Pro Asn Ser Phe Gln Gly Lys Val Ala Phe Ile 
     50                  55                  60
Thr Gly Gly Gly Thr Gly Leu Gly Lys Gly Met Thr Thr Leu Leu Ser 
 65                  70                  75                  80
Ser Leu Gly Ala Gln Cys Val Ile Ala Ser Arg Lys Met Asp Val Leu 
                 85                  90                  95
Lys Ala Thr Ala Glu Gln Ile Ser Ser Gln Thr Gly Asn Lys Val His 
             100                105                110
Ala Ile Gln Cys Asp Val Arg Asp Pro Asp Met Val Gln Asn Thr Val 
         115                120                125
Ser Glu Leu Ile Lys Val Ala Gly His Pro Asn Ile Val Ile Asn Asn 
     130                135                140
Ala Ala Gly Asn Phe Ile Ser Pro Thr Glu Arg Leu Ser Pro Asn Ala 
 145                150                155                160
Trp Lys Thr Ile Thr Asp Ile Val Leu Asn Gly Thr Ala Phe Val Thr 
                 165                170                175
Leu Glu Ile Gly Lys Gln Leu Ile Lys Ala Gln Lys Gly Ala Ala Phe 
             180                185                190
Leu Ser Ile Thr Thr Ile Tyr Ala Glu Thr Gly Ser Gly Phe Val Val 
         195                200                205
Pro Ser Ala Ser Ala Lys Ala Gly Val Glu Ala Met Ser Lys Ser Leu 
     210                215                220
Ala Ala Glu Trp Gly Lys Tyr Gly Met Arg Phe Asn Val Ile Gln Pro 
 225                230                235                240
Gly Pro Ile Lys Thr Lys Gly Ala Phe Ser Arg Leu Asp Pro Thr Gly 
                 245                250                255
Thr Phe Glu Lys Glu Met Ile Gly Arg Ile Pro Cys Gly Arg Leu Gly 
             260                265                270
Thr Val Glu Glu Leu Ala Asn Leu Ala Ala Phe Leu Cys Ser Asp Tyr 
         275                280                285
Ala Ser Trp Ile Asn Gly Ala Val Ile Lys Phe Asp Gly Gly Glu Glu 
     290                295                300
Val Leu Ile Ser Gly Glu Phe Asn Asp Leu Arg Lys Val Thr Lys Glu 
 305                310                315                320
Gln Trp Asp Thr Ile Glu Glu Leu Ile Arg Lys Thr Lys Gly Ser 
                 325                330                335



<210> 1539
<211> 1109
<212> DNA
<213> Rattus norvegicus
<308> D00569
<400> 1539

gaattccct  ctgcaaaca  ggcgctgct  gcccgtgcg  tctttgctg  ggtgtcccg  60
ctcccctgc  atcccggtc  tcagaagtt  ttcagcttt  gaacgaaaa  cctgtatca  120
agcatcgat  ctccacagt  taaattctt  ccacccatt  taaagccta  gctaccacc  180
aatgccttt  aaggaaaag  ggctttcat  acgggagga  gcactggcc  tggcaaggc  240
atgacaact  tccgctcca  cctgggtgc  cagtgtgtg  tcgcgagca  gaatattga  300
gttctgaaa  ctactgcag  agagattac  tctaaaact  gaaataagg  ctatgcgat  360
cggtgtgac  ttcgagatc  tgatatggt  cacaacaca  tactggagc  gatcaaagt  420
gcagggcat  ctgatgtgg  gataaacaa  gcggcaggg  acttcattt  tcccagtga  480
agactgtct  ccaatggtt  gaggaccat  actgacata  ttctcaatg  tacagccta  540
gtgacgata  aaattggaa  gcagctaat  aaagcacag  aaggagtcg  ctttcttgc  600
atcactacg  tctatgctg  gagcggatc  ggctttgta  tgccaagtt  ttcagccaa  660
tcaggcgtg  aagccatga  taagtctct  gcagctgaa  ggggtagat  cggaatgcg  720
ttcaacata  ttcagccag  gcctatcaa  accaaaggt  cctttagcc  tttggaccc  780
actggaaaa  ttgagaaag  tatgatcga  agaatcccc  gtggtcggc  gggaactgt  840
gaggaactt  ccaatctag  gactttcct  tgcagtgat  atgcctctt  gatcaatgg  900
gcagtcatt  gatttgacg  tggagagga  gtgtttctg  caggtgaat  caactctct  960
aagaaggtc  ccaaggagg  gtgggatgt  atcgaaggc  tcatcagaa  gacaaaagg  1020
tcctaagac  ttcatggct  cctctgtga  aaactaaag  ttagggact  tatagatgg  1080
catttgagt  aataaattt  ttgtctgat  1109



<210> 1540
<211> 335
<212> PRT
<213> Rattus norvegicus
<308> Q64591
<400> 1540

Met Ala Leu Leu Ala Arg Ala Phe Phe Ala Gly Val Ser Arg Leu Pro 
  1               5                  10                  15
Cys Asp Pro Gly Pro Gln Lys Phe Phe Ser Phe Gly Thr Lys Thr Leu 
             20                  25                  30
Tyr Gln Ser Ile Asp Ala Pro Gln Ser Lys Phe Phe Pro Pro Ile Leu 
         35                  40                  45
Lys Pro Met Leu Pro Pro Asn Ala Phe Gln Gly Lys Val Ala Phe Ile 
     50                  55                  60
Thr Gly Gly Gly Thr Gly Leu Gly Lys Ala Met Thr Thr Phe Arg Ser 
 65                  70                  75                  80
Ser Leu Gly Ala Gln Cys Val Ile Ala Ser Arg Asn Ile Asp Val Leu 
                 85                  90                  95
Lys Ala Thr Ala Glu Glu Ile Thr Ser Lys Thr Gly Asn Lys Val Tyr 
             100                105                110
Ala Ile Arg Cys Asp Val Arg Asp Pro Asp Met Val His Asn Thr Val 
         115                120                125
Leu Glu Leu Ile Lys Val Ala Gly His Pro Asp Val Val Ile Asn Asn 
     130                135                140
Ala Ala Gly Asn Phe Ile Ser Pro Ser Glu Arg Leu Ser Pro Asn Gly 
 145                150                155                160
Trp Arg Thr Ile Thr Asp Ile Val Leu Asn Gly Thr Ala Tyr Val Thr 
                 165                170                175
Ile Glu Ile Gly Lys Gln Leu Ile Lys Ala Gln Lys Gly Val Ala Phe 
             180                185                190
Leu Ala Ile Thr Thr Ile Tyr Ala Glu Ser Gly Ser Gly Phe Val Met 
         195                200                205
Pro Ser Ser Ser Ala Lys Ser Gly Val Glu Ala Met Asn Lys Ser Leu 
     210                215                220
Ala Ala Glu Trp Gly Arg Tyr Gly Met Arg Phe Asn Ile Ile Gln Pro 
 225                230                235                240
Gly Pro Ile Lys Thr Lys Gly Ala Phe Ser Arg Leu Asp Pro Thr Gly 
                 245                250                255
Lys Phe Glu Lys Asp Met Ile Glu Arg Ile Pro Cys Gly Arg Leu Gly 
             260                265                270
Thr Val Glu Glu Leu Ala Asn Leu Ala Thr Phe Leu Cys Ser Asp Tyr 
         275                280                285
Ala Ser Trp Ile Asn Gly Ala Val Ile Arg Phe Asp Gly Gly Glu Glu 
     290                295                300
Val Phe Leu Ser Gly Glu Phe Asn Ser Leu Lys Lys Val Thr Lys Glu 
 305                310                315                320
Glu Trp Asp Val Ile Glu Gly Leu Ile Arg Lys Thr Lys Gly Ser 
                 325                330                335



<210> 1541
<211> 1120
<212> DNA
<213> Homo sapiens
<308> L26050
<400> 1541

gagactcaa  atgaagcta  cggccaggg  tttctttac  ctggggtcc  ggctgccct  60
tggcctcgc  cctcggagg  ttttcagtt  tgggacaaa  atattatat  aaaacactg  120
agctttgca  tctaaattc  tttcacctc  tcaaaaagc  atgctacca  ctaatagtt  180
tcaaggaaa  gtggcattc  ttactgggg  aggtactgg  cttggtaaa  gaatgacaa  240
tcttctgtc  agcctaggt  ctcagtgcg  gatagccag  cggaagatg  atgttttga  300
agctaccgc  gaacaaatt  cttctcaaa  tggaaataa  gttcatgca  ttcagtgtg  360
tgtgaggga  cctgatatg  ttcaaaaca  tgtgtcaga  ctgatcaaa  ttgcaggac  420
tcctaatat  gtgataaac  atgcagcag  gaattttat  tctcctact  aaagacttt  480
tcctaatgc  tggaaaacc  taactgaca  agttctaaa  ggcacagcc  tcgtgacac  540
agaaattgg  aaacaacta  ttaaagcac  gaaaggagc  gcatttctt  ctattacta  600
tatctatgc  gagactggt  caggttttg  agtaccaag  gcttctgcc  aagcaggtg  660
ggaagccat  agcaagtct  ttgcagctg  atggggtaa  tatggaatg  gattcaatg  720
gattcaacc  gggcctata  aaaccaaag  tgcctttag  cgtctggac  caactggaa  780
atttgagaa  gaaatgatt  gcagaattc  ctgtggtcg  ctggggact  tagaagaac  840
cgcaaatct  gctgctttc  tttgtagtg  ttatgcttc  tggattaat  gagcagtca  900
taaatttga  ggtggagag  aagtactta  ttcagggga  ttcaacgac  tgagaaagg  960
caccaagga  cagtgggac  ccatagaag  actcatcag  aagacaaaa  gttcctaag  1020
ccactttgg  cttcatctt  gttacagaa  agggaatag  aatgaaaca  attatctct  1080
atcttttga  tatttcaag  ctaataaat  cttaattaac  1120



<210> 1542
<211> 335
<212> PRT
<213> Homo sapiens
<308> Q16698
<400> 1542

Met Lys Leu Pro Ala Arg Val Phe Phe Thr Leu Gly Ser Arg Leu Pro 
  1               5                  10                  15
Cys Gly Leu Ala Pro Arg Arg Phe Phe Ser Tyr Gly Thr Lys Ile Leu 
             20                  25                  30
Tyr Gln Asn Thr Glu Ala Leu Gln Ser Lys Phe Phe Ser Pro Leu Gln 
         35                  40                  45
Lys Ala Met Leu Pro Pro Asn Ser Phe Gln Gly Lys Val Ala Phe Ile 
     50                  55                  60
Thr Gly Gly Gly Thr Gly Leu Gly Lys Gly Met Thr Thr Leu Leu Ser 
 65                  70                  75                  80
Ser Leu Gly Ala Gln Cys Val Ile Ala Ser Arg Lys Met Asp Val Leu 
                 85                  90                  95
Lys Ala Thr Ala Glu Gln Ile Ser Ser Gln Thr Gly Asn Lys Val His 
             100                105                110
Ala Ile Gln Cys Asp Val Arg Asp Pro Asp Met Val Gln Asn Thr Val 
         115                120                125
Ser Glu Leu Ile Lys Val Ala Gly His Pro Asn Ile Val Ile Asn Asn 
     130                135                140
Ala Ala Gly Asn Phe Ile Ser Pro Thr Glu Arg Leu Ser Pro Asn Ala 
 145                150                155                160
Trp Lys Thr Ile Thr Asp Ile Val Leu Asn Gly Thr Ala Phe Val Thr 
                 165                170                175
Leu Glu Ile Gly Lys Gln Leu Ile Lys Ala Gln Lys Gly Ala Ala Phe 
             180                185                190
Leu Ser Ile Thr Thr Ile Tyr Ala Glu Thr Gly Ser Gly Phe Val Val 
         195                200                205
Pro Ser Ala Ser Ala Lys Ala Gly Val Glu Ala Met Ser Lys Ser Leu 
     210                215                220
Ala Ala Glu Trp Gly Lys Tyr Gly Met Arg Phe Asn Val Ile Gln Pro 
 225                230                235                240
Gly Pro Ile Lys Thr Lys Gly Ala Phe Ser Arg Leu Asp Pro Thr Gly 
                 245                250                255
Thr Phe Glu Lys Glu Met Ile Gly Arg Ile Pro Cys Gly Arg Leu Gly 
             260                265                270
Thr Val Glu Glu Leu Ala Asn Leu Ala Ala Phe Leu Cys Ser Asp Tyr 
         275                280                285
Ala Ser Trp Ile Asn Gly Ala Val Ile Lys Phe Asp Gly Gly Glu Glu 
     290                295                300
Val Leu Ile Ser Gly Glu Phe Asn Asp Leu Arg Lys Val Thr Lys Glu 
 305                310                315                320
Gln Trp Asp Thr Ile Glu Glu Leu Ile Arg Lys Thr Lys Gly Ser 
                 325                330                335



<210> 1543
<211> 1109
<212> DNA
<213> Rattus norvegicus
<308> D00569
<400> 1543

gaattccct  ctgcaaaca  ggcgctgct  gcccgtgcg  tctttgctg  ggtgtcccg  60
ctcccctgc  atcccggtc  tcagaagtt  ttcagcttt  gaacgaaaa  cctgtatca  120
agcatcgat  ctccacagt  taaattctt  ccacccatt  taaagccta  gctaccacc  180
aatgccttt  aaggaaaag  ggctttcat  acgggagga  gcactggcc  tggcaaggc  240
atgacaact  tccgctcca  cctgggtgc  cagtgtgtg  tcgcgagca  gaatattga  300
gttctgaaa  ctactgcag  agagattac  tctaaaact  gaaataagg  ctatgcgat  360
cggtgtgac  ttcgagatc  tgatatggt  cacaacaca  tactggagc  gatcaaagt  420
gcagggcat  ctgatgtgg  gataaacaa  gcggcaggg  acttcattt  tcccagtga  480
agactgtct  ccaatggtt  gaggaccat  actgacata  ttctcaatg  tacagccta  540
gtgacgata  aaattggaa  gcagctaat  aaagcacag  aaggagtcg  ctttcttgc  600
atcactacg  tctatgctg  gagcggatc  ggctttgta  tgccaagtt  ttcagccaa  660
tcaggcgtg  aagccatga  taagtctct  gcagctgaa  ggggtagat  cggaatgcg  720
ttcaacata  ttcagccag  gcctatcaa  accaaaggt  cctttagcc  tttggaccc  780
actggaaaa  ttgagaaag  tatgatcga  agaatcccc  gtggtcggc  gggaactgt  840
gaggaactt  ccaatctag  gactttcct  tgcagtgat  atgcctctt  gatcaatgg  900
gcagtcatt  gatttgacg  tggagagga  gtgtttctg  caggtgaat  caactctct  960
aagaaggtc  ccaaggagg  gtgggatgt  atcgaaggc  tcatcagaa  gacaaaagg  1020
tcctaagac  ttcatggct  cctctgtga  aaactaaag  ttagggact  tatagatgg  1080
catttgagt  aataaattt  ttgtctgat  1109



<210> 1544
<211> 335
<212> PRT
<213> Rattus norvegicus
<308> Q64591
<400> 1544

Met Ala Leu Leu Ala Arg Ala Phe Phe Ala Gly Val Ser Arg Leu Pro 
  1               5                  10                  15
Cys Asp Pro Gly Pro Gln Lys Phe Phe Ser Phe Gly Thr Lys Thr Leu 
             20                  25                  30
Tyr Gln Ser Ile Asp Ala Pro Gln Ser Lys Phe Phe Pro Pro Ile Leu 
         35                  40                  45
Lys Pro Met Leu Pro Pro Asn Ala Phe Gln Gly Lys Val Ala Phe Ile 
     50                  55                  60
Thr Gly Gly Gly Thr Gly Leu Gly Lys Ala Met Thr Thr Phe Arg Ser 
 65                  70                  75                  80
Ser Leu Gly Ala Gln Cys Val Ile Ala Ser Arg Asn Ile Asp Val Leu 
                 85                  90                  95
Lys Ala Thr Ala Glu Glu Ile Thr Ser Lys Thr Gly Asn Lys Val Tyr 
             100                105                110
Ala Ile Arg Cys Asp Val Arg Asp Pro Asp Met Val His Asn Thr Val 
         115                120                125
Leu Glu Leu Ile Lys Val Ala Gly His Pro Asp Val Val Ile Asn Asn 
     130                135                140
Ala Ala Gly Asn Phe Ile Ser Pro Ser Glu Arg Leu Ser Pro Asn Gly 
 145                150                155                160
Trp Arg Thr Ile Thr Asp Ile Val Leu Asn Gly Thr Ala Tyr Val Thr 
                 165                170                175
Ile Glu Ile Gly Lys Gln Leu Ile Lys Ala Gln Lys Gly Val Ala Phe 
             180                185                190
Leu Ala Ile Thr Thr Ile Tyr Ala Glu Ser Gly Ser Gly Phe Val Met 
         195                200                205
Pro Ser Ser Ser Ala Lys Ser Gly Val Glu Ala Met Asn Lys Ser Leu 
     210                215                220
Ala Ala Glu Trp Gly Arg Tyr Gly Met Arg Phe Asn Ile Ile Gln Pro 
 225                230                235                240
Gly Pro Ile Lys Thr Lys Gly Ala Phe Ser Arg Leu Asp Pro Thr Gly 
                 245                250                255
Lys Phe Glu Lys Asp Met Ile Glu Arg Ile Pro Cys Gly Arg Leu Gly 
             260                265                270
Thr Val Glu Glu Leu Ala Asn Leu Ala Thr Phe Leu Cys Ser Asp Tyr 
         275                280                285
Ala Ser Trp Ile Asn Gly Ala Val Ile Arg Phe Asp Gly Gly Glu Glu 
     290                295                300
Val Phe Leu Ser Gly Glu Phe Asn Ser Leu Lys Lys Val Thr Lys Glu 
 305                310                315                320
Glu Trp Asp Val Ile Glu Gly Leu Ile Arg Lys Thr Lys Gly Ser 
                 325                330                335



<210> 1545
<211> 1120
<212> DNA
<213> Homo sapiens
<308> L26050
<400> 1545

gagactcaa  atgaagcta  cggccaggg  tttctttac  ctggggtcc  ggctgccct  60
tggcctcgc  cctcggagg  ttttcagtt  tgggacaaa  atattatat  aaaacactg  120
agctttgca  tctaaattc  tttcacctc  tcaaaaagc  atgctacca  ctaatagtt  180
tcaaggaaa  gtggcattc  ttactgggg  aggtactgg  cttggtaaa  gaatgacaa  240
tcttctgtc  agcctaggt  ctcagtgcg  gatagccag  cggaagatg  atgttttga  300
agctaccgc  gaacaaatt  cttctcaaa  tggaaataa  gttcatgca  ttcagtgtg  360
tgtgaggga  cctgatatg  ttcaaaaca  tgtgtcaga  ctgatcaaa  ttgcaggac  420
tcctaatat  gtgataaac  atgcagcag  gaattttat  tctcctact  aaagacttt  480
tcctaatgc  tggaaaacc  taactgaca  agttctaaa  ggcacagcc  tcgtgacac  540
agaaattgg  aaacaacta  ttaaagcac  gaaaggagc  gcatttctt  ctattacta  600
tatctatgc  gagactggt  caggttttg  agtaccaag  gcttctgcc  aagcaggtg  660
ggaagccat  agcaagtct  ttgcagctg  atggggtaa  tatggaatg  gattcaatg  720
gattcaacc  gggcctata  aaaccaaag  tgcctttag  cgtctggac  caactggaa  780
atttgagaa  gaaatgatt  gcagaattc  ctgtggtcg  ctggggact  tagaagaac  840
cgcaaatct  gctgctttc  tttgtagtg  ttatgcttc  tggattaat  gagcagtca  900
taaatttga  ggtggagag  aagtactta  ttcagggga  ttcaacgac  tgagaaagg  960
caccaagga  cagtgggac  ccatagaag  actcatcag  aagacaaaa  gttcctaag  1020
ccactttgg  cttcatctt  gttacagaa  agggaatag  aatgaaaca  attatctct  1080
atcttttga  tatttcaag  ctaataaat  cttaattaac  1120



<210> 1546
<211> 335
<212> PRT
<213> Homo sapiens
<308> Q16698
<400> 1546

Met Lys Leu Pro Ala Arg Val Phe Phe Thr Leu Gly Ser Arg Leu Pro 
  1               5                  10                  15
Cys Gly Leu Ala Pro Arg Arg Phe Phe Ser Tyr Gly Thr Lys Ile Leu 
             20                  25                  30
Tyr Gln Asn Thr Glu Ala Leu Gln Ser Lys Phe Phe Ser Pro Leu Gln 
         35                  40                  45
Lys Ala Met Leu Pro Pro Asn Ser Phe Gln Gly Lys Val Ala Phe Ile 
     50                  55                  60
Thr Gly Gly Gly Thr Gly Leu Gly Lys Gly Met Thr Thr Leu Leu Ser 
 65                  70                  75                  80
Ser Leu Gly Ala Gln Cys Val Ile Ala Ser Arg Lys Met Asp Val Leu 
                 85                  90                  95
Lys Ala Thr Ala Glu Gln Ile Ser Ser Gln Thr Gly Asn Lys Val His 
             100                105                110
Ala Ile Gln Cys Asp Val Arg Asp Pro Asp Met Val Gln Asn Thr Val 
         115                120                125
Ser Glu Leu Ile Lys Val Ala Gly His Pro Asn Ile Val Ile Asn Asn 
     130                135                140
Ala Ala Gly Asn Phe Ile Ser Pro Thr Glu Arg Leu Ser Pro Asn Ala 
 145                150                155                160
Trp Lys Thr Ile Thr Asp Ile Val Leu Asn Gly Thr Ala Phe Val Thr 
                 165                170                175
Leu Glu Ile Gly Lys Gln Leu Ile Lys Ala Gln Lys Gly Ala Ala Phe 
             180                185                190
Leu Ser Ile Thr Thr Ile Tyr Ala Glu Thr Gly Ser Gly Phe Val Val 
         195                200                205
Pro Ser Ala Ser Ala Lys Ala Gly Val Glu Ala Met Ser Lys Ser Leu 
     210                215                220
Ala Ala Glu Trp Gly Lys Tyr Gly Met Arg Phe Asn Val Ile Gln Pro 
 225                230                235                240
Gly Pro Ile Lys Thr Lys Gly Ala Phe Ser Arg Leu Asp Pro Thr Gly 
                 245                250                255
Thr Phe Glu Lys Glu Met Ile Gly Arg Ile Pro Cys Gly Arg Leu Gly 
             260                265                270
Thr Val Glu Glu Leu Ala Asn Leu Ala Ala Phe Leu Cys Ser Asp Tyr 
         275                280                285
Ala Ser Trp Ile Asn Gly Ala Val Ile Lys Phe Asp Gly Gly Glu Glu 
     290                295                300
Val Leu Ile Ser Gly Glu Phe Asn Asp Leu Arg Lys Val Thr Lys Glu 
 305                310                315                320
Gln Trp Asp Thr Ile Glu Glu Leu Ile Arg Lys Thr Lys Gly Ser 
                 325                330                335



<210> 1547
<211> 1893
<212> DNA
<213> Rattus norvegicus
<308> D00636
<400> 1547

gggtgtaga  cggtgccac  actgtcttc  tcgccacca  gggggccca  ctgagcacg  60
tgagccgag  ggtactctc  ccggtctgg  tcgtctaca  cctcttcat  aagctgttt  120
agcgctcct  accggccat  accctcgag  accccgaca  caagtaccc  ctgcggctc  180
tcgacaagg  gattatcag  cacgacact  ggcgcttcc  atttgcact  ccttcgccc  240
agcacatcc  gggccttcc  atcggccag  acatctacc  ctccaccag  atcgatggc  300
acttggtca  tcgtcccta  acccctgtg  ctagtgatg  tgacaaggg  tttgtggac  360
tggtggtca  ggtttactt  aaggacacg  atcccaagt  tccagctgg  gggaaaatg  420
ctcagtacc  ggaaaacat  aatattgga  acaccattg  attccgggg  cccaatggg  480
tactggtct  ccagggcaa  gggaagttc  ccatccgtg  agacaagaa  tccaaccct  540
ttgtcagga  ggtgaagtc  gtaggcatg  ttgcaggag  gacaggcat  accccaatg  600
tgcaggtga  ccgagccgt  ttgaaggac  cgaacgacc  cactgtgtg  tatctgctc  660
tcgccaacc  gtccgagaa  gacatcctg  tgcggcctg  gctggagga  ctgaggaac  720
aacattctt  tcgcttcaa  ctctggtac  cagtggaca  agcccccga  gcctgggac  780
atagccaag  cttcgtgaa  gaggagatg  tcagggacc  tcttccacc  cctggggag  840
agacactga  actgatgtg  ggaccccca  cgatgatcc  gtttgcctg  ttgccaaac  900
tggagcgtg  gggccatcc  aaggagcga  gcttcacct  ctgatggct  gatgctggc  960
actcccatg  ctgctgctc  cgcactcac  acaaccacc  tccacccct  ccttcccca  1020
tactgtcct  taccctgac  tatgcccac  tccatgctg  ggcctgggt  cagcctggc  1080
tgcccagcc  tggtcatcc  gctgtactg  cccctgagg  gcccctttg  gagcaggcc  1140
gtgtatcag  tggcttctg  tgaccactt  ctgaatagg  ttctgtctg  tactaactg  1200
ccattacca  agatggtcc  tgaccaccc  tttatacac  cacacatac  catacagag  1260
cagagagac  gagagacag  gatagacag  gatagacag  gagacagat  cagacatag  1320
gacagacag  gacagagag  gaggagtca  agagctgtt  gtaccatgt  tacccgtta  1380
catggaccg  aatgtgtag  aaggaaatg  aaggtaaac  gttatctac  gtcctagga  1440
ccatgcctg  cacctaacc  cctactgcc  taggctatg  cctggtctg  gcccctaaa  1500
actacatta  acagtgaca  ccagaggtt  tcttaggag  gtgtctggc  gtgacaggc  1560
agcccccac  tgctggcca  gagttcctt  ggtcagcac  tggaccctt  caaaacccc  1620
cacactgcc  ctcccctcc  tgatgcctt  agcacccta  gttgtcagc  caacagagt  1680
tggtagacc  tggggtacc  ggcttgttt  tccatccca  acctccctc  catctggtt  1740
ccagcctgg  gggttctga  cagagcctc  tttctcgga  acagacccg  tgcctggcg  1800
tgccttcag  agacagcag  cagcctcct  cacactggc  ttttttagt  atttatggg  1860
aaaatgagt  aaaataaaa  tttgcaaat  ctg  1893



<210> 1548
<211> 300
<212> PRT
<213> Rattus norvegicus
<308> BAA00530
<400> 1548

Gly Ala Gln Leu Ser Thr Leu Ser Arg Val Val Leu Ser Pro Val Trp 
  1               5                  10                  15
Phe Val Tyr Ser Leu Phe Met Lys Leu Phe Gln Arg Ser Ser Pro Ala 
             20                  25                  30
Ile Thr Leu Glu Asn Pro Asp Ile Lys Tyr Pro Leu Arg Leu Ile Asp 
         35                  40                  45
Lys Glu Ile Ile Ser His Asp Thr Arg Arg Phe Arg Phe Ala Leu Pro 
     50                  55                  60
Ser Pro Gln His Ile Leu Gly Leu Pro Ile Gly Gln His Ile Tyr Leu 
 65                  70                  75                  80
Ser Thr Arg Ile Asp Gly Asn Leu Val Ile Arg Pro Tyr Thr Pro Val 
                 85                  90                  95
Ser Ser Asp Asp Asp Lys Gly Phe Val Asp Leu Val Val Lys Val Tyr 
             100                105                110
Phe Lys Asp Thr His Pro Lys Phe Pro Ala Gly Gly Lys Met Ser Gln 
         115                120                125
Tyr Leu Glu Asn Met Asn Ile Gly Asp Thr Ile Glu Phe Arg Gly Pro 
     130                135                140
Asn Gly Leu Leu Val Tyr Gln Gly Lys Gly Lys Phe Ala Ile Arg Ala 
 145                150                155                160
Asp Lys Lys Ser Asn Pro Val Val Arg Thr Val Lys Ser Val Gly Met 
                 165                170                175
Ile Ala Gly Gly Thr Gly Ile Thr Pro Met Leu Gln Val Ile Arg Ala 
             180                185                190
Val Leu Lys Asp Pro Asn Asp His Thr Val Cys Tyr Leu Leu Phe Ala 
         195                200                205
Asn Gln Ser Glu Lys Asp Ile Leu Leu Arg Pro Glu Leu Glu Glu Leu 
     210                215                220
Arg Asn Glu His Ser Ser Arg Phe Lys Leu Trp Tyr Thr Val Asp Lys 
 225                230                235                240
Ala Pro Asp Ala Trp Asp Tyr Ser Gln Gly Phe Val Asn Glu Glu Met 
                 245                250                255
Ile Arg Asp His Leu Pro Pro Pro Gly Glu Glu Thr Leu Ile Leu Met 
             260                265                270
Cys Gly Pro Pro Pro Met Ile Gln Phe Ala Cys Leu Pro Asn Leu Glu 
         275                280                285
Arg Val Gly His Pro Lys Glu Arg Cys Phe Thr Phe 
     290                295                300



<210> 1549
<211> 1921
<212> DNA
<213> Homo sapiens
<308> NM_000398
<400> 1549

cgcgacggt  tcggcggcg  cggcggcgg  gacagagcg  gcgcggcgc  ggccaccat  60
ggggcccag  tcagcacgt  gggccatat  gtgctcttc  cagtctggt  cctgtacag  120
ctgctcatg  agctgttcc  gcgctccac  ccagccatc  ccctcgaga  cccggacat  180
aagtacccg  tgcggctca  cgaccggga  atcatcagc  atgacaccc  gcgcttccg  240
tttgccctg  cgtcacccc  gcacatcct  ggcctccct  tcggccagc  catctacct  300
tcggctcga  ttgatggaa  cctggtcgt  cggccctat  cacccatct  cagcgatga  360
gacaagggc  tcgtggacc  ggtcatcaa  gtttacttc  aggacaccc  tcccaagtt  420
cccgctgga  ggaagatgt  tcagtacct  gagagcatg  agattggag  caccattga  480
ttccggggc  ccagtgggc  gctggtcta  cagggcaaa  ggaagttcg  catccgacc  540
gacaaaaag  ccaacccta  catcaggac  gtgaagtct  tgggcatga  cgcgggagg  600
acaggcatc  ccccgatgc  gcaggtgat  cgcgccatc  tgaaggacc  tgatgacca  660
actgtgtgc  acctgctct  tgccaacca  accgagaag  acatcctgc  gcgacctga  720
ctggaggaa  tcaggaaca  acattctgc  cgcttcaag  tctggtaca  gctggacag  780
gcccctgaa  cctgggact  cggccaggg  ttcgtgaat  aggagatga  ccgggacca  840
cttccaccc  cagaggagg  gccgctggt  ctgatgtgt  gccccccac  catgatcca  900
tacgcctgc  ttcccaacc  ggaccacgt  ggccacccc  cggagcgct  cttcgtctt  960
tgagggccg  gcaccggtc  cacggccac  gcccccgcg  accccacgc  ctgttcacg  1020
tcacccagt  acctcccca  atcgcacac  ggggccccg  gttcagcct  gcctgcccg  1080
gccctggtg  atcacctgg  tgagcagtt  ccctggagc  ccttcggga  cagggctgt  1140
tcccagatg  gccacggct  agccttcag  gtacgtcct  cctggcact  actggtcct  1200
accagagac  cccagcccc  tccctgtcc  catgacccc  cgtccaccc  ccacacaca  1260
tataaggct  agggctgcc  gcagccccg  ctgcccacc  ttcccggcc  tggaccata  1320
tcgggatgt  agcagacac  catggcagg  ccaaagctg  aggtcccag  gcccacccc  1380
gccacgcct  tcaccccca  tcccgcctc  gggccaggc  caggcctca  cacctgacg  1440
tgcatgaga  attgacacc  gaaagccct  ttgggggca  tgctcccta  cccagggcc  1500
tggccagcc  ggagcttgg  tctcctctg  ctagagtgg  aagaggggg  tggccatgg  1560
gccctccca  aacctcagc  tttccttcc  gcccatcca  acactgagg  agccttggg  1620
aaccccgag  tggggggtt  gcagcccac  gcaccgcct  agggttttg  ggtcctggg  1680
tggggccac  tccctgatg  cagaactcc  acaaccaca  gtatttatt  ctctgtcct  1740
aaccgtccc  tccttccct  acccccagc  cagggggat  ctgagcagt  cctcttgtc  1800
gagggacat  tcagtgacc  cgacgttgc  tttagacta  agttgtgtt  gcctcttgc  1860
tattggctt  ttcagagtc  tttatgagc  gaaaaaaaa  aagtaaaac  ttgctaata  1920
t  1921



<210> 1550
<211> 300
<212> PRT
<213> Homo sapiens
<308> P00387
<400> 1550

Gly Ala Gln Leu Ser Thr Leu Gly His Met Val Leu Phe Pro Val Trp 
  1               5                  10                  15
Phe Leu Tyr Ser Leu Leu Met Lys Leu Phe Gln Arg Ser Thr Pro Ala 
             20                  25                  30
Ile Thr Leu Glu Ser Pro Asp Ile Lys Tyr Pro Leu Arg Leu Ile Asp 
         35                  40                  45
Arg Glu Ile Ile Ser His Asp Thr Arg Arg Phe Arg Phe Ala Leu Pro 
     50                  55                  60
Ser Pro Gln His Ile Leu Gly Leu Pro Val Gly Gln His Ile Tyr Leu 
 65                  70                  75                  80
Ser Ala Arg Ile Asp Gly Asn Leu Val Val Arg Pro Tyr Thr Pro Ile 
                 85                  90                  95
Ser Ser Asp Asp Asp Lys Gly Phe Val Asp Leu Val Ile Lys Val Tyr 
             100                105                110
Phe Lys Asp Thr His Pro Lys Phe Pro Ala Gly Gly Lys Met Ser Gln 
         115                120                125
Tyr Leu Glu Ser Met Gln Ile Gly Asp Thr Ile Glu Phe Arg Gly Pro 
     130                135                140
Ser Gly Leu Leu Val Tyr Gln Gly Lys Gly Lys Phe Ala Ile Arg Pro 
 145                150                155                160
Asp Lys Lys Ser Asn Pro Ile Ile Arg Thr Val Lys Ser Val Gly Met 
                 165                170                175
Ile Ala Gly Gly Thr Gly Ile Thr Pro Met Leu Gln Val Ile Arg Ala 
             180                185                190
Ile Met Lys Asp Pro Asp Asp His Thr Val Cys His Leu Leu Phe Ala 
         195                200                205
Asn Gln Thr Glu Lys Asp Ile Leu Leu Arg Pro Glu Leu Glu Glu Leu 
     210                215                220
Arg Asn Lys His Ser Ala Arg Phe Lys Leu Trp Tyr Thr Leu Asp Arg 
 225                230                235                240
Ala Pro Glu Ala Trp Asp Tyr Gly Gln Gly Phe Val Asn Glu Glu Met 
                 245                250                255
Ile Arg Asp His Leu Pro Pro Pro Glu Glu Glu Pro Leu Val Leu Met 
             260                265                270
Cys Gly Pro Pro Pro Met Ile Gln Tyr Ala Cys Leu Pro Asn Leu Asp 
         275                280                285
His Val Gly His Pro Thr Glu Arg Cys Phe Val Phe 
     290                295                300



<210> 1551
<211> 1893
<212> DNA
<213> Rattus norvegicus
<308> D00636
<400> 1551

gggtgtaga  cggtgccac  actgtcttc  tcgccacca  gggggccca  ctgagcacg  60
tgagccgag  ggtactctc  ccggtctgg  tcgtctaca  cctcttcat  aagctgttt  120
agcgctcct  accggccat  accctcgag  accccgaca  caagtaccc  ctgcggctc  180
tcgacaagg  gattatcag  cacgacact  ggcgcttcc  atttgcact  ccttcgccc  240
agcacatcc  gggccttcc  atcggccag  acatctacc  ctccaccag  atcgatggc  300
acttggtca  tcgtcccta  acccctgtg  ctagtgatg  tgacaaggg  tttgtggac  360
tggtggtca  ggtttactt  aaggacacg  atcccaagt  tccagctgg  gggaaaatg  420
ctcagtacc  ggaaaacat  aatattgga  acaccattg  attccgggg  cccaatggg  480
tactggtct  ccagggcaa  gggaagttc  ccatccgtg  agacaagaa  tccaaccct  540
ttgtcagga  ggtgaagtc  gtaggcatg  ttgcaggag  gacaggcat  accccaatg  600
tgcaggtga  ccgagccgt  ttgaaggac  cgaacgacc  cactgtgtg  tatctgctc  660
tcgccaacc  gtccgagaa  gacatcctg  tgcggcctg  gctggagga  ctgaggaac  720
aacattctt  tcgcttcaa  ctctggtac  cagtggaca  agcccccga  gcctgggac  780
atagccaag  cttcgtgaa  gaggagatg  tcagggacc  tcttccacc  cctggggag  840
agacactga  actgatgtg  ggaccccca  cgatgatcc  gtttgcctg  ttgccaaac  900
tggagcgtg  gggccatcc  aaggagcga  gcttcacct  ctgatggct  gatgctggc  960
actcccatg  ctgctgctc  cgcactcac  acaaccacc  tccacccct  ccttcccca  1020
tactgtcct  taccctgac  tatgcccac  tccatgctg  ggcctgggt  cagcctggc  1080
tgcccagcc  tggtcatcc  gctgtactg  cccctgagg  gcccctttg  gagcaggcc  1140
gtgtatcag  tggcttctg  tgaccactt  ctgaatagg  ttctgtctg  tactaactg  1200
ccattacca  agatggtcc  tgaccaccc  tttatacac  cacacatac  catacagag  1260
cagagagac  gagagacag  gatagacag  gatagacag  gagacagat  cagacatag  1320
gacagacag  gacagagag  gaggagtca  agagctgtt  gtaccatgt  tacccgtta  1380
catggaccg  aatgtgtag  aaggaaatg  aaggtaaac  gttatctac  gtcctagga  1440
ccatgcctg  cacctaacc  cctactgcc  taggctatg  cctggtctg  gcccctaaa  1500
actacatta  acagtgaca  ccagaggtt  tcttaggag  gtgtctggc  gtgacaggc  1560
agcccccac  tgctggcca  gagttcctt  ggtcagcac  tggaccctt  caaaacccc  1620
cacactgcc  ctcccctcc  tgatgcctt  agcacccta  gttgtcagc  caacagagt  1680
tggtagacc  tggggtacc  ggcttgttt  tccatccca  acctccctc  catctggtt  1740
ccagcctgg  gggttctga  cagagcctc  tttctcgga  acagacccg  tgcctggcg  1800
tgccttcag  agacagcag  cagcctcct  cacactggc  ttttttagt  atttatggg  1860
aaaatgagt  aaaataaaa  tttgcaaat  ctg  1893



<210> 1552
<211> 300
<212> PRT
<213> Rattus norvegicus
<308> BAA00530
<400> 1552

Gly Ala Gln Leu Ser Thr Leu Ser Arg Val Val Leu Ser Pro Val Trp 
  1               5                  10                  15
Phe Val Tyr Ser Leu Phe Met Lys Leu Phe Gln Arg Ser Ser Pro Ala 
             20                  25                  30
Ile Thr Leu Glu Asn Pro Asp Ile Lys Tyr Pro Leu Arg Leu Ile Asp 
         35                  40                  45
Lys Glu Ile Ile Ser His Asp Thr Arg Arg Phe Arg Phe Ala Leu Pro 
     50                  55                  60
Ser Pro Gln His Ile Leu Gly Leu Pro Ile Gly Gln His Ile Tyr Leu 
 65                  70                  75                  80
Ser Thr Arg Ile Asp Gly Asn Leu Val Ile Arg Pro Tyr Thr Pro Val 
                 85                  90                  95
Ser Ser Asp Asp Asp Lys Gly Phe Val Asp Leu Val Val Lys Val Tyr 
             100                105                110
Phe Lys Asp Thr His Pro Lys Phe Pro Ala Gly Gly Lys Met Ser Gln 
         115                120                125
Tyr Leu Glu Asn Met Asn Ile Gly Asp Thr Ile Glu Phe Arg Gly Pro 
     130                135                140
Asn Gly Leu Leu Val Tyr Gln Gly Lys Gly Lys Phe Ala Ile Arg Ala 
 145                150                155                160
Asp Lys Lys Ser Asn Pro Val Val Arg Thr Val Lys Ser Val Gly Met 
                 165                170                175
Ile Ala Gly Gly Thr Gly Ile Thr Pro Met Leu Gln Val Ile Arg Ala 
             180                185                190
Val Leu Lys Asp Pro Asn Asp His Thr Val Cys Tyr Leu Leu Phe Ala 
         195                200                205
Asn Gln Ser Glu Lys Asp Ile Leu Leu Arg Pro Glu Leu Glu Glu Leu 
     210                215                220
Arg Asn Glu His Ser Ser Arg Phe Lys Leu Trp Tyr Thr Val Asp Lys 
 225                230                235                240
Ala Pro Asp Ala Trp Asp Tyr Ser Gln Gly Phe Val Asn Glu Glu Met 
                 245                250                255
Ile Arg Asp His Leu Pro Pro Pro Gly Glu Glu Thr Leu Ile Leu Met 
             260                265                270
Cys Gly Pro Pro Pro Met Ile Gln Phe Ala Cys Leu Pro Asn Leu Glu 
         275                280                285
Arg Val Gly His Pro Lys Glu Arg Cys Phe Thr Phe 
     290                295                300



<210> 1553
<211> 1921
<212> DNA
<213> Homo sapiens
<308> NM_000398
<400> 1553

cgcgacggt  tcggcggcg  cggcggcgg  gacagagcg  gcgcggcgc  ggccaccat  60
ggggcccag  tcagcacgt  gggccatat  gtgctcttc  cagtctggt  cctgtacag  120
ctgctcatg  agctgttcc  gcgctccac  ccagccatc  ccctcgaga  cccggacat  180
aagtacccg  tgcggctca  cgaccggga  atcatcagc  atgacaccc  gcgcttccg  240
tttgccctg  cgtcacccc  gcacatcct  ggcctccct  tcggccagc  catctacct  300
tcggctcga  ttgatggaa  cctggtcgt  cggccctat  cacccatct  cagcgatga  360
gacaagggc  tcgtggacc  ggtcatcaa  gtttacttc  aggacaccc  tcccaagtt  420
cccgctgga  ggaagatgt  tcagtacct  gagagcatg  agattggag  caccattga  480
ttccggggc  ccagtgggc  gctggtcta  cagggcaaa  ggaagttcg  catccgacc  540
gacaaaaag  ccaacccta  catcaggac  gtgaagtct  tgggcatga  cgcgggagg  600
acaggcatc  ccccgatgc  gcaggtgat  cgcgccatc  tgaaggacc  tgatgacca  660
actgtgtgc  acctgctct  tgccaacca  accgagaag  acatcctgc  gcgacctga  720
ctggaggaa  tcaggaaca  acattctgc  cgcttcaag  tctggtaca  gctggacag  780
gcccctgaa  cctgggact  cggccaggg  ttcgtgaat  aggagatga  ccgggacca  840
cttccaccc  cagaggagg  gccgctggt  ctgatgtgt  gccccccac  catgatcca  900
tacgcctgc  ttcccaacc  ggaccacgt  ggccacccc  cggagcgct  cttcgtctt  960
tgagggccg  gcaccggtc  cacggccac  gcccccgcg  accccacgc  ctgttcacg  1020
tcacccagt  acctcccca  atcgcacac  ggggccccg  gttcagcct  gcctgcccg  1080
gccctggtg  atcacctgg  tgagcagtt  ccctggagc  ccttcggga  cagggctgt  1140
tcccagatg  gccacggct  agccttcag  gtacgtcct  cctggcact  actggtcct  1200
accagagac  cccagcccc  tccctgtcc  catgacccc  cgtccaccc  ccacacaca  1260
tataaggct  agggctgcc  gcagccccg  ctgcccacc  ttcccggcc  tggaccata  1320
tcgggatgt  agcagacac  catggcagg  ccaaagctg  aggtcccag  gcccacccc  1380
gccacgcct  tcaccccca  tcccgcctc  gggccaggc  caggcctca  cacctgacg  1440
tgcatgaga  attgacacc  gaaagccct  ttgggggca  tgctcccta  cccagggcc  1500
tggccagcc  ggagcttgg  tctcctctg  ctagagtgg  aagaggggg  tggccatgg  1560
gccctccca  aacctcagc  tttccttcc  gcccatcca  acactgagg  agccttggg  1620
aaccccgag  tggggggtt  gcagcccac  gcaccgcct  agggttttg  ggtcctggg  1680
tggggccac  tccctgatg  cagaactcc  acaaccaca  gtatttatt  ctctgtcct  1740
aaccgtccc  tccttccct  acccccagc  cagggggat  ctgagcagt  cctcttgtc  1800
gagggacat  tcagtgacc  cgacgttgc  tttagacta  agttgtgtt  gcctcttgc  1860
tattggctt  ttcagagtc  tttatgagc  gaaaaaaaa  aagtaaaac  ttgctaata  1920
t  1921



<210> 1554
<211> 300
<212> PRT
<213> Homo sapiens
<308> P00387
<400> 1554

Gly Ala Gln Leu Ser Thr Leu Gly His Met Val Leu Phe Pro Val Trp 
  1               5                  10                  15
Phe Leu Tyr Ser Leu Leu Met Lys Leu Phe Gln Arg Ser Thr Pro Ala 
             20                  25                  30
Ile Thr Leu Glu Ser Pro Asp Ile Lys Tyr Pro Leu Arg Leu Ile Asp 
         35                  40                  45
Arg Glu Ile Ile Ser His Asp Thr Arg Arg Phe Arg Phe Ala Leu Pro 
     50                  55                  60
Ser Pro Gln His Ile Leu Gly Leu Pro Val Gly Gln His Ile Tyr Leu 
 65                  70                  75                  80
Ser Ala Arg Ile Asp Gly Asn Leu Val Val Arg Pro Tyr Thr Pro Ile 
                 85                  90                  95
Ser Ser Asp Asp Asp Lys Gly Phe Val Asp Leu Val Ile Lys Val Tyr 
             100                105                110
Phe Lys Asp Thr His Pro Lys Phe Pro Ala Gly Gly Lys Met Ser Gln 
         115                120                125
Tyr Leu Glu Ser Met Gln Ile Gly Asp Thr Ile Glu Phe Arg Gly Pro 
     130                135                140
Ser Gly Leu Leu Val Tyr Gln Gly Lys Gly Lys Phe Ala Ile Arg Pro 
 145                150                155                160
Asp Lys Lys Ser Asn Pro Ile Ile Arg Thr Val Lys Ser Val Gly Met 
                 165                170                175
Ile Ala Gly Gly Thr Gly Ile Thr Pro Met Leu Gln Val Ile Arg Ala 
             180                185                190
Ile Met Lys Asp Pro Asp Asp His Thr Val Cys His Leu Leu Phe Ala 
         195                200                205
Asn Gln Thr Glu Lys Asp Ile Leu Leu Arg Pro Glu Leu Glu Glu Leu 
     210                215                220
Arg Asn Lys His Ser Ala Arg Phe Lys Leu Trp Tyr Thr Leu Asp Arg 
 225                230                235                240
Ala Pro Glu Ala Trp Asp Tyr Gly Gln Gly Phe Val Asn Glu Glu Met 
                 245                250                255
Ile Arg Asp His Leu Pro Pro Pro Glu Glu Glu Pro Leu Val Leu Met 
             260                265                270
Cys Gly Pro Pro Pro Met Ile Gln Tyr Ala Cys Leu Pro Asn Leu Asp 
         275                280                285
His Val Gly His Pro Thr Glu Arg Cys Phe Val Phe 
     290                295                300



<210> 1555
<211> 2513
<212> DNA
<213> Rattus norvegicus
<308> D00688
<400> 1555

gaattcctg  cggatctgg  gaagcccaa  ctcgcaggc  acatgttcg  cgtaggtct  60
attggaggc  gcatctcag  attggctgc  gccaaactg  tgtctgaat  caaaattaa  120
gtcttggtt  tggaagccc  ggatagagt  ggaggaaga  catatactg  gaggaatga  180
catgtcaaa  gggtagatg  tggtggagc  tatgtggga  caacccaga  cagaatctt  240
cgcttgtct  aggagctag  catagagac  tataaagtg  atgtcaatg  gcgtctagt  300
caatatgtc  aggggaaaa  ttacccatt  cgtggtgca  tcccacctg  gtggaaccc  360
ttggcatat  tggattaca  caacctatg  agaacaatg  atgaaatgg  aaaagagat  420
cccgttgat  caccgtggc  agcaagaca  gctcaggaa  gggacaaga  gaccatgaa  480
gatctcatt  ataaaatct  ttggacaaa  actgctcgg  aatttgcgt  tctttttgt  540
aacattaat  tgacttctg  gcctcatga  gtatctgcc  tgtggttcc  gtggtatgt  600
aggcagtgt  ggggcactg  tcggatatt  tcagttacc  atggcggcc  ggaacggaa  660
tttgtaggt  gatctggcc  agtaagtga  cagataatg  gtctccttg  agataaagt  720
aagctgagc  ctcctgtta  ttatattga  caaacagat  acaacatca  tgtagaaac  780
ctgaatcat  aacactatg  gtgcaaata  gtaattagt  ccatcccac  gattttgac  840
gccaagatc  actttaaac  agagcttcc  cctgagaga  accaattaa  tcagcgtct  900
ccaatgggg  ctgttatca  gtgcatggt  tattacaag  aagccttct  gaagaaaaa  960
gactattgt  gctgcatga  cattgaaga  gaggaggct  caatcgcca  cactctgga  1020
gacactaaa  cagatgggt  actgcctgc  atcatgggc  tcatacttg  ccggaaagc  1080
gatcgacaa  ctaaactac  taaagacat  aggaagagg  aaatctgtg  gctgtatgc  1140
aaagttctg  gatctcaag  agcattata  ccagtccat  atgaagaga  gaactggtg  1200
gaggagcag  actccgggg  ctgctacac  gcctacttc  ctcctggta  catgaccca  1260
tatggaagg  tgattcgcc  gccagtagg  aggatttac  ttgcaggca  agagacagc  1320
acacagtgg  gtggctaca  ggaaggagc  gttgaagct  gagaacgag  agctagaga  1380
gtgttgaat  ctctaggaa  agtcgcgaa  aaggatata  gggttgaag  acccgagtc  1440
aaggatgtt  cagccattg  aattaccca  accttctta  agaggaacc  gccttccgt  1500
cctggtctg  tcaagatca  tggtgtttc  acttctgtg  ctcttctct  ctttgtatt  1560
tacaagatt  agaagctcc  atgctgaag  ttcaccctc  ggcctcctg  acgatcatc  1620
catgtgaaa  aaagtgtgg  taaattaca  cctatggtt  gggccattt  agtgcactt  1680
atttaaccc  catcagttt  atttcagtc  ttgtaaagt  ataacaatc  aaagaatca  1740
ctagctaat  tccataaga  caagtttca  cctgtttgt  agactaatt  gtgtgggtt  1800
agagaataa  atgttgagt  cttaatttc  aaaagtgaa  tgcttctga  gaataattt  1860
tgggttctt  tgttttctt  ttgccttta  tgcaaaata  ctaattcag  aataaaaca  1920
ttgacttac  gtgactttt  tgtagcgtc  aaggtgtac  gaggaaaat  gtggctgaa  1980
tgttcccta  gtatcctca  tgactagct  catgtgata  acactaccc  tggcacttt  2040
ttttctgga  tgtatctag  catgcattg  cccttgtca  taacattct  tgctgattt  2100
aggaaatta  cattatttt  atatagtcc  tagttatct  atcagagga  tagatctct  2160
agtctacct  tgtcttcaa  atggttata  ttttctgtt  gttgatagt  taccatttt  2220
tctcaatta  caaaggaca  atgaaatgt  ctctattgt  atttgttga  acagtcaaa  2280
acagaaatt  aatttgggc  ctgtgtgat  acatgactt  cttgaatta  taggtttta  2340
agcagacat  aaattggat  attttatat  cccaaacta  ggtctctat  ttaggagtg  2400
tgtgggtcc  gaatgatgt  tgtcttttc  ctttcccat  tgaaaaatt  tcaattaaa  2460
aaacttttc  aaggtttca  ccacaaagc  cttcttttt  taaaaaaaa  aaa  2513



<210> 1556
<211> 526
<212> PRT
<213> Rattus norvegicus
<308> BAA00592
<400> 1556

Met Thr Asp Leu Glu Lys Pro Asn Leu Ala Gly His Met Phe Asp Val 
  1               5                  10                  15
Gly Leu Ile Gly Gly Gly Ile Ser Gly Leu Ala Ala Ala Lys Leu Leu 
             20                  25                  30
Ser Glu Tyr Lys Ile Asn Val Leu Val Leu Glu Ala Arg Asp Arg Val 
         35                  40                  45
Gly Gly Arg Thr Tyr Thr Val Arg Asn Glu His Val Lys Trp Val Asp 
     50                  55                  60
Val Gly Gly Ala Tyr Val Gly Pro Thr Gln Asn Arg Ile Leu Arg Leu 
 65                  70                  75                  80
Ser Lys Glu Leu Gly Ile Glu Thr Tyr Lys Val Asn Val Asn Glu Arg 
                 85                  90                  95
Leu Val Gln Tyr Val Lys Gly Lys Thr Tyr Pro Phe Arg Gly Ala Phe 
             100                105                110
Pro Pro Val Trp Asn Pro Leu Ala Tyr Leu Asp Tyr Asn Asn Leu Trp 
         115                120                125
Arg Thr Met Asp Glu Met Gly Lys Glu Ile Pro Val Asp Ala Pro Trp 
     130                135                140
Gln Ala Arg His Ala Gln Glu Trp Asp Lys Met Thr Met Lys Asp Leu 
 145                150                155                160
Ile Asp Lys Ile Cys Trp Thr Lys Thr Ala Arg Glu Phe Ala Tyr Leu 
                 165                170                175
Phe Val Asn Ile Asn Val Thr Ser Glu Pro His Glu Val Ser Ala Leu 
             180                185                190
Trp Phe Leu Trp Tyr Val Arg Gln Cys Gly Gly Thr Ala Arg Ile Phe 
         195                200                205
Ser Val Thr Asn Gly Gly Gln Glu Arg Lys Phe Val Gly Gly Ser Gly 
     210                215                220
Gln Val Ser Glu Gln Ile Met Gly Leu Leu Gly Asp Lys Val Lys Leu 
 225                230                235                240
Ser Ser Pro Val Thr Tyr Ile Asp Gln Thr Asp Asp Asn Ile Ile Val 
                 245                250                255
Glu Thr Leu Asn His Glu His Tyr Glu Cys Lys Tyr Val Ile Ser Ala 
             260                265                270
Ile Pro Pro Ile Leu Thr Ala Lys Ile His Phe Lys Pro Glu Leu Pro 
         275                280                285
Pro Glu Arg Asn Gln Leu Ile Gln Arg Leu Pro Met Gly Ala Val Ile 
     290                295                300
Lys Cys Met Val Tyr Tyr Lys Glu Ala Phe Trp Lys Lys Lys Asp Tyr 
 305                310                315                320
Cys Gly Cys Met Ile Ile Glu Asp Glu Glu Ala Pro Ile Ala Ile Thr 
                 325                330                335
Leu Asp Asp Thr Lys Pro Asp Gly Ser Leu Pro Ala Ile Met Gly Phe 
             340                345                350
Ile Leu Ala Arg Lys Ala Asp Arg Gln Ala Lys Leu His Lys Asp Ile 
         355                360                365
Arg Lys Arg Lys Ile Cys Glu Leu Tyr Ala Lys Val Leu Gly Ser Gln 
     370                375                380
Glu Ala Leu Tyr Pro Val His Tyr Glu Glu Lys Asn Trp Cys Glu Glu 
 385                390                395                400
Gln Tyr Ser Gly Gly Cys Tyr Thr Ala Tyr Phe Pro Pro Gly Ile Met 
                 405                410                415
Thr Gln Tyr Gly Arg Val Ile Arg Gln Pro Val Gly Arg Ile Tyr Phe 
             420                425                430
Ala Gly Thr Glu Thr Ala Thr Gln Trp Ser Gly Tyr Met Glu Gly Ala 
         435                440                445
Val Glu Ala Gly Glu Arg Ala Ala Arg Glu Val Leu Asn Ala Leu Gly 
     450                455                460
Lys Val Ala Lys Lys Asp Ile Trp Val Glu Glu Pro Glu Ser Lys Asp 
 465                470                475                480
Val Pro Ala Ile Glu Ile Thr His Thr Phe Leu Glu Arg Asn Leu Pro 
                 485                490                495
Ser Val Pro Gly Leu Leu Lys Ile Thr Gly Val Ser Thr Ser Val Ala 
             500                505                510
Leu Leu Cys Phe Val Leu Tyr Lys Ile Lys Lys Leu Pro Cys 
         515                520                525



<210> 1557
<211> 1925
<212> DNA
<213> Homo sapiens
<308> NM_000240
<400> 1557

ctgacacgc  cctgggtcg  aggcacagg  gtgggggcc  aagcatgga  aatcaagag  60
aggcgagta  cgcgggcca  atgttcgac  tagtcgtga  cggaggtgg  atttcagga  120
tatctgctg  caaactctt  actgaatat  gcgttagtg  tttggtttt  gaagctcgg  180
acagggttg  aggaagaac  tatactata  ggaatgagc  tgttgatta  gtagatgtt  240
gtggagctt  tgtgggacc  acccaaaac  gaatcttac  cttgtctaa  gagctgggc  300
tagagactt  caaagtgaa  gtcagtgag  gtctcgttc  atatgtcaa  gggaaaaca  360
atccatttc  gggcgcctt  ccaccagta  ggaatccca  tgcatattt  gattacaat  420
atctgtgga  gacaataga  aacatgggg  aggagattc  aactgatgc  ccctgggag  480
ctcaacatg  tgacaaatg  gacaaaatg  ccatgaaag  gctcattga  aaaatctgc  540
ggacaaaga  tgctaggcg  tttgcttat  tttttgtga  tatcaatgt  acctctgag  600
ctcacgaag  gtctgccct  tggttcttg  ggtatgtga  gcagtgcgg  ggcaccact  660
ggatattct  tgtcaccaa  ggtggccag  aacggaagt  tgtaggtgg  tctggtcaa  720
tgagcgaac  gataatgga  ctcctcgga  accaagtga  gctgaacca  cctgtcact  780
acgttgacc  gtcaagtga  aacatcatc  tagagacgc  gaaccatga  cattatgag  840
gcaaatacg  aattaatgc  atccctccg  ccttgactg  caagattca  ttcagacca  900
agcttccag  agagagaaa  cagttaatt  agcgtcttc  aatgggagc  gtcattaag  960
gcatgatgt  ttacaagga  gccttctgg  agaagaagg  ttactgtgg  tgcatgatc  1020
ttgaagatg  agatgctcc  atttcaata  ccttggatg  caccaagcc  gatgggtca  1080
tgcctgcca  catgggctt  attcttgcc  ggaaagctg  tcgacttgc  aagctacat  1140
aggaaataa  gaagaagaa  atctgtgag  tctatgcca  agtgctggg  tcccaagaa  1200
ctttacatc  agtgcatta  gaagagaag  actggtgtg  ggagcagta  tctgggggc  1260
gctacacgg  ctacttccc  cctgggatc  tgactcaat  tggaagggt  attcgtcaa  1320
ccgtgggca  gattttctt  gcgggcaca  agactgcca  aaagtggag  ggctacatg  1380
aaggggcag  tgaggctgg  gaacgagca  ctagggagg  cttaaatgg  ctcgggaag  1440
tgaccgaga  agacatctg  gtacaagaa  ctgaatcaa  ggacgttcc  gcggtagaa  1500
tcacccaca  cttctggga  aggaacctg  cctctgttt  tggcctgct  aagatcatt  1560
gattttcca  atcagtaac  gccctgggg  ttgtgctgt  caaatacaa  ctcctgcca  1620
ggtcttgaa  ttctgttct  atgctctct  ctcactggt  ttcaatacc  ccaagagga  1680
aatattgac  agtttaaag  ctgtgtcat  gggccatgt  taagtgtac  ggatttaac  1740
acctttggc  taattccaa  cattgttaa  gtaaaaaca  ttcaaagaa  cacctaatt  1800
atttcagta  gatcaagct  catcttatt  gtcagtgta  atcaactca  gttaattga  1860
agaataaag  cttgtgatc  ctttctgaa  ttcacaaag  taaacgtga  gtgctcatc  1920
gaaac  1925



<210> 1558
<211> 527
<212> PRT
<213> Homo sapiens
<308> P21397
<400> 1558

Met Glu Asn Gln Glu Lys Ala Ser Ile Ala Gly His Met Phe Asp Val 
  1               5                  10                  15
Val Val Ile Gly Gly Gly Ile Ser Gly Leu Ser Ala Ala Lys Leu Leu 
             20                  25                  30
Thr Glu Tyr Gly Val Ser Val Leu Val Leu Glu Ala Arg Asp Arg Val 
         35                  40                  45
Gly Gly Arg Thr Tyr Thr Ile Arg Asn Glu His Val Asp Tyr Val Asp 
     50                  55                  60
Val Gly Gly Ala Tyr Val Gly Pro Thr Gln Asn Arg Ile Leu Arg Leu 
 65                  70                  75                  80
Ser Lys Glu Leu Gly Ile Glu Thr Tyr Lys Val Asn Val Ser Glu Arg 
                 85                  90                  95
Leu Val Gln Tyr Val Lys Gly Lys Thr Tyr Pro Phe Arg Gly Ala Phe 
             100                105                110
Pro Pro Val Trp Asn Pro Ile Ala Tyr Leu Asp Tyr Asn Asn Leu Trp 
         115                120                125
Arg Thr Ile Asp Asn Met Gly Lys Glu Ile Pro Thr Asp Ala Pro Trp 
     130                135                140
Glu Ala Gln His Ala Asp Lys Trp Asp Lys Met Thr Met Lys Glu Leu 
 145                150                155                160
Ile Asp Lys Ile Cys Trp Thr Lys Thr Ala Arg Arg Phe Ala Tyr Leu 
                 165                170                175
Phe Val Asn Ile Asn Val Thr Ser Glu Pro His Glu Val Ser Ala Leu 
             180                185                190
Trp Phe Leu Trp Tyr Val Lys Gln Cys Gly Gly Thr Thr Arg Ile Phe 
         195                200                205
Ser Val Thr Asn Gly Gly Gln Glu Arg Lys Phe Val Gly Gly Ser Gly 
     210                215                220
Gln Val Ser Glu Arg Ile Met Asp Leu Leu Gly Asp Gln Val Lys Leu 
 225                230                235                240
Asn His Pro Val Thr His Val Asp Gln Ser Ser Asp Asn Ile Ile Ile 
                 245                250                255
Glu Thr Leu Asn His Glu His Tyr Glu Cys Lys Tyr Val Ile Asn Ala 
             260                265                270
Ile Pro Pro Thr Leu Thr Ala Lys Ile His Phe Arg Pro Glu Leu Pro 
         275                280                285
Ala Glu Arg Asn Gln Leu Ile Gln Arg Leu Pro Met Gly Ala Val Ile 
     290                295                300
Lys Cys Met Met Tyr Tyr Lys Glu Ala Phe Trp Lys Lys Lys Asp Tyr 
 305                310                315                320
Cys Gly Cys Met Ile Ile Glu Asp Glu Asp Ala Pro Ile Ser Ile Thr 
                 325                330                335
Leu Asp Asp Thr Lys Pro Asp Gly Ser Leu Pro Ala Ile Met Gly Phe 
             340                345                350
Ile Leu Ala Arg Lys Ala Asp Arg Leu Ala Lys Leu His Lys Glu Ile 
         355                360                365
Arg Lys Lys Lys Ile Cys Glu Leu Tyr Ala Lys Val Leu Gly Ser Gln 
     370                375                380
Glu Ala Leu His Pro Val His Tyr Glu Glu Lys Asn Trp Cys Glu Glu 
 385                390                395                400
Gln Tyr Ser Gly Gly Cys Tyr Thr Ala Tyr Phe Pro Pro Gly Ile Met 
                 405                410                415
Thr Gln Tyr Gly Arg Val Ile Arg Gln Pro Val Gly Arg Ile Phe Phe 
             420                425                430
Ala Gly Thr Glu Thr Ala Thr Lys Trp Ser Gly Tyr Met Glu Gly Ala 
         435                440                445
Val Glu Ala Gly Glu Arg Ala Ala Arg Glu Val Leu Asn Gly Leu Gly 
     450                455                460
Lys Val Thr Glu Lys Asp Ile Trp Val Gln Glu Pro Glu Ser Lys Asp 
 465                470                475                480
Val Pro Ala Val Glu Ile Thr His Thr Phe Trp Glu Arg Asn Leu Pro 
                 485                490                495
Ser Val Ser Gly Leu Leu Lys Ile Ile Gly Phe Ser Thr Ser Val Thr 
             500                505                510
Ala Leu Gly Phe Val Leu Tyr Lys Tyr Lys Leu Leu Pro Arg Ser 
         515                520                525



<210> 1559
<211> 1083
<212> DNA
<213> Rattus norvegicus
<308> D00729
<400> 1559

acacaactc  caatcatcc  gtgaactgg  ctgactgtg  caggacctg  gcggtgagg  60
aacccttgg  gacaccgat  tggcttgag  ctgctcctc  tcttggcgc  ggcctctcc  120
gtcgcgttc  gctgcaggc  ggatcccgc  tcgccgcag  ggggcctgg  cgagcccgt  180
gcttctcta  caaggcggt  ttggtggag  aggagggcg  ggcaggaat  gcagtgatg  240
agttcaaga  ccctccagt  aattcctca  cttggagtt  ccgacagag  tttcgtcat  300
agcctgaga  gctggaaaa  gaaaagagc  tccgaggtg  catcctcac  tcggagcgc  360
cgggaacct  cccgccgcc  cacgacatg  agaagaagg  cgaccagcc  actatgctg  420
gtactggaa  gctcgtgcc  ggagctgtg  ctgaggctc  acttgtcca  cctgacttg  480
tatctgcca  caatggcgc  tttccagct  gaggctgcc  catggctct  acctgtgac  540
acaggataa  ggcggacaa  tccaagtat  ccataggat  gaatgagag  ctgctgggc  600
ttgttgccc  cttctggtt  aaagacaac  acgtgaaca  atcgggcac  gagcagccg  660
gcgtgccct  caactgggg  cgttttccc  ctaacatga  agcagctgc  ctactgacg  720
ttcacagaa  cctcaatga  gtggtacct  aggatcagg  acacagcaa  gctcgctca  780
tgatggcca  gtggtttac  attccggac  attctcggt  gctgacgaa  agcatgatg  840
gcaaggcca  ggcggacaa  ctgatcaag  agcgagagg  tgacatcca  aacttcacc  900
gtttcacct  cagagactc  atccagaag  ccctgcacg  gtacttgga  aagctcaag  960
aaaagaagg  ctgacctaa  ggtgccaca  ggtgtttag  tacacgtgc  ttctaggga  1020
ccatggtcc  aaggattat  aataaggta  ttttcaatt  aaaaaaaaa  aaaaaggaa  1080
tcc  1083



<210> 1560
<211> 298
<212> PRT
<213> Rattus norvegicus
<308> BAA00629
<400> 1560

Met Trp Leu Glu Pro Ala Pro Leu Leu Gly Ala Gly Leu Ser Arg Arg 
  1               5                  10                  15
Val Leu Leu Gln Ala Gly Ser Arg Leu Ala Ala Gly Gly Pro Gly Arg 
             20                  25                  30
Ala Arg Arg Phe Ser Asn Lys Ala Val Leu Val Glu Lys Glu Gly Glu 
         35                  40                  45
Ala Gly Ile Ala Val Met Lys Phe Lys Asn Pro Pro Val Asn Ser Ser 
     50                  55                  60
Ala Trp Ser Phe Arg Gln Ser Phe Arg His Gln Pro Glu Lys Leu Glu 
 65                  70                  75                  80
Asn Glu Lys Ser Ile Arg Gly Val Ile Leu Thr Ser Glu Arg Pro Gly 
                 85                  90                  95
Thr Ser Pro Pro Pro His Asp Met Lys Lys Lys Asp Asp Gln Pro Thr 
             100                105                110
Met Leu Ser Thr Gly Arg Leu Val Pro Gly Ala Val Ala Glu Ala Leu 
         115                120                125
Leu Val Gln Pro Asp Leu Ile Ser Ala Ile Asn Gly Ala Phe Pro Ala 
     130                135                140
Gly Gly Cys Leu Met Ala Leu Thr Cys Asp Tyr Arg Ile Met Ala Asp 
 145                150                155                160
Asn Ser Lys Tyr Thr Ile Gly Leu Asn Glu Ser Leu Leu Gly Ile Val 
                 165                170                175
Ala Pro Phe Trp Leu Lys Asp Asn Tyr Val Asn Thr Ser Gly Thr Glu 
             180                185                190
Gln Pro Ser Val Pro Phe Asn Trp Gly Arg Phe Pro Thr Asn Met Thr 
         195                200                205
Ala Ala Ala Leu Leu Thr Leu His Arg Ser Leu Asn Glu Val Val Pro 
     210                215                220
Glu Asp Gln Val His Ser Lys Ala Arg Ser Val Met Ala Lys Trp Phe 
 225                230                235                240
Thr Ile Pro Asp His Ser Arg Leu Leu Thr Lys Ser Met Met Arg Lys 
                 245                250                255
Ala Thr Ala Asp Asn Leu Ile Lys Gln Arg Glu Ala Asp Ile Gln Asn 
             260                265                270
Phe Thr Ser Phe Thr Ser Arg Asp Ser Ile Gln Lys Ser Leu His Val 
         275                280                285
Tyr Leu Glu Lys Leu Lys Gln Lys Lys Gly 
     290                295



<210> 1561
<211> 1017
<212> DNA
<213> Homo sapiens
<308> Z25820
<400> 1561

cggtcaaga  ggcgctggt  gcttctgtg  gagtcccgg  gcgcgttct  ctccgcgcg  60
gggcccggc  cccgggcgc  gccctcggg  ggacggagc  ggcggccgg  ggcggagac  120
gcgcgcggc  gttcgggag  cagcgggtg  tggtggagc  ggacgcggc  gcaggggtc  180
ctgtgatga  attcaagaa  cccccagtg  acagcctga  cctggagtt  ctgacggag  240
tggtcatca  cctggagaa  ctggagaat  acaagagct  ccgcggtgt  attctgacc  300
cggaccgcc  gggtgtctt  tcggccggc  tggacctga  ggagatgtg  gggaggagc  360
ccgcccact  cgctgggta  tggaaggcc  ttcaggagc  gtggctgcg  ttgtaccag  420
ccaacctgg  gctggtctc  gccatcaac  gagcctgcc  cgctggagg  tgcctggtg  480
ccctgacct  tgactaccg  atcctggcg  acaacccca  gtactgcat  ggactcaat  540
agacccagc  gggcatcat  gcccctttc  ggttgaaag  caccctgga  aacaccatc  600
ggcaccggg  ggcggagcg  gccctgcag  tggggctgc  cttcccgcc  gcggaggcc  660
tgcaggtgg  catagtgga  caggtggtc  cggaggagc  ggtgcagag  actgcgctg  720
cagcgatag  ccagtggat  gccattcca  accatgctc  acagctgac  aaggccatg  780
tgcgaaagg  cacggccag  cgcctggtc  cgcagcgcg  tgcggacgt  cagaacttc  840
tcagcttca  ctccaaaga  tccatccag  agtccctgc  gatgtactt  gagaggctc  900
aagaagaaa  aggctaacg  ttgggctgc  acaggctta  ggccacacg  gcccctgtg  960
gtcccaggg  ggtcttaaa  aaggtattt  tcaacttaa  aaaaaaaaa  aaaaaaa  1017



<210> 1562
<211> 302
<212> PRT
<213> Homo sapiens
<308> P42126
<400> 1562

Met Ala Leu Val Ala Ser Val Arg Val Pro Ala Arg Val Leu Leu Arg 
  1               5                  10                  15
Ala Gly Ala Arg Leu Pro Gly Ala Ala Leu Gly Arg Thr Glu Arg Ala 
             20                  25                  30
Ala Gly Gly Gly Asp Gly Ala Arg Arg Phe Gly Ser Gln Arg Val Leu 
         35                  40                  45
Val Glu Pro Asp Ala Gly Ala Gly Val Ala Val Met Lys Phe Lys Asn 
     50                  55                  60
Pro Pro Val Asn Ser Leu Ser Leu Glu Phe Leu Thr Glu Leu Val Ile 
 65                  70                  75                  80
Ser Leu Glu Lys Leu Glu Asn Asp Lys Ser Phe Arg Gly Val Ile Leu 
                 85                  90                  95
Thr Ser Asp Arg Pro Gly Val Phe Ser Ala Gly Leu Asp Leu Thr Glu 
             100                105                110
Met Cys Gly Arg Ser Pro Ala His Tyr Ala Gly Tyr Trp Lys Ala Val 
         115                120                125
Gln Glu Leu Trp Leu Arg Leu Tyr Gln Ser Asn Leu Val Leu Val Ser 
     130                135                140
Ala Ile Asn Gly Ala Cys Pro Ala Gly Gly Cys Leu Val Ala Leu Thr 
 145                150                155                160
Cys Asp Tyr Arg Ile Leu Ala Asp Asn Pro Arg Tyr Cys Ile Gly Leu 
                 165                170                175
Asn Glu Thr Gln Leu Gly Ile Ile Ala Pro Phe Trp Leu Lys Asp Thr 
             180                185                190
Leu Glu Asn Thr Ile Gly His Arg Ala Ala Glu Arg Ala Leu Gln Leu 
         195                200                205
Gly Leu Leu Phe Pro Pro Ala Glu Ala Leu Gln Val Gly Ile Val Asp 
     210                215                220
Gln Val Val Pro Glu Glu Gln Val Gln Ser Thr Ala Leu Ser Ala Ile 
 225                230                235                240
Ala Gln Trp Met Ala Ile Pro Asp His Ala Arg Gln Leu Thr Lys Ala 
                 245                250                255
Met Met Arg Lys Ala Thr Ala Ser Arg Leu Val Thr Gln Arg Asp Ala 
             260                265                270
Asp Val Gln Asn Phe Val Ser Phe Ile Ser Lys Asp Ser Ile Gln Lys 
         275                280                285
Ser Leu Gln Met Tyr Leu Glu Arg Leu Lys Glu Glu Lys Gly 
     290                295                300



<210> 1563
<211> 1083
<212> DNA
<213> Rattus norvegicus
<308> D00729
<400> 1563

acacaactc  caatcatcc  gtgaactgg  ctgactgtg  caggacctg  gcggtgagg  60
aacccttgg  gacaccgat  tggcttgag  ctgctcctc  tcttggcgc  ggcctctcc  120
gtcgcgttc  gctgcaggc  ggatcccgc  tcgccgcag  ggggcctgg  cgagcccgt  180
gcttctcta  caaggcggt  ttggtggag  aggagggcg  ggcaggaat  gcagtgatg  240
agttcaaga  ccctccagt  aattcctca  cttggagtt  ccgacagag  tttcgtcat  300
agcctgaga  gctggaaaa  gaaaagagc  tccgaggtg  catcctcac  tcggagcgc  360
cgggaacct  cccgccgcc  cacgacatg  agaagaagg  cgaccagcc  actatgctg  420
gtactggaa  gctcgtgcc  ggagctgtg  ctgaggctc  acttgtcca  cctgacttg  480
tatctgcca  caatggcgc  tttccagct  gaggctgcc  catggctct  acctgtgac  540
acaggataa  ggcggacaa  tccaagtat  ccataggat  gaatgagag  ctgctgggc  600
ttgttgccc  cttctggtt  aaagacaac  acgtgaaca  atcgggcac  gagcagccg  660
gcgtgccct  caactgggg  cgttttccc  ctaacatga  agcagctgc  ctactgacg  720
ttcacagaa  cctcaatga  gtggtacct  aggatcagg  acacagcaa  gctcgctca  780
tgatggcca  gtggtttac  attccggac  attctcggt  gctgacgaa  agcatgatg  840
gcaaggcca  ggcggacaa  ctgatcaag  agcgagagg  tgacatcca  aacttcacc  900
gtttcacct  cagagactc  atccagaag  ccctgcacg  gtacttgga  aagctcaag  960
aaaagaagg  ctgacctaa  ggtgccaca  ggtgtttag  tacacgtgc  ttctaggga  1020
ccatggtcc  aaggattat  aataaggta  ttttcaatt  aaaaaaaaa  aaaaaggaa  1080
tcc  1083



<210> 1564
<211> 298
<212> PRT
<213> Rattus norvegicus
<308> BAA00629
<400> 1564

Met Trp Leu Glu Pro Ala Pro Leu Leu Gly Ala Gly Leu Ser Arg Arg 
  1               5                  10                  15
Val Leu Leu Gln Ala Gly Ser Arg Leu Ala Ala Gly Gly Pro Gly Arg 
             20                  25                  30
Ala Arg Arg Phe Ser Asn Lys Ala Val Leu Val Glu Lys Glu Gly Glu 
         35                  40                  45
Ala Gly Ile Ala Val Met Lys Phe Lys Asn Pro Pro Val Asn Ser Ser 
     50                  55                  60
Ala Trp Ser Phe Arg Gln Ser Phe Arg His Gln Pro Glu Lys Leu Glu 
 65                  70                  75                  80
Asn Glu Lys Ser Ile Arg Gly Val Ile Leu Thr Ser Glu Arg Pro Gly 
                 85                  90                  95
Thr Ser Pro Pro Pro His Asp Met Lys Lys Lys Asp Asp Gln Pro Thr 
             100                105                110
Met Leu Ser Thr Gly Arg Leu Val Pro Gly Ala Val Ala Glu Ala Leu 
         115                120                125
Leu Val Gln Pro Asp Leu Ile Ser Ala Ile Asn Gly Ala Phe Pro Ala 
     130                135                140
Gly Gly Cys Leu Met Ala Leu Thr Cys Asp Tyr Arg Ile Met Ala Asp 
 145                150                155                160
Asn Ser Lys Tyr Thr Ile Gly Leu Asn Glu Ser Leu Leu Gly Ile Val 
                 165                170                175
Ala Pro Phe Trp Leu Lys Asp Asn Tyr Val Asn Thr Ser Gly Thr Glu 
             180                185                190
Gln Pro Ser Val Pro Phe Asn Trp Gly Arg Phe Pro Thr Asn Met Thr 
         195                200                205
Ala Ala Ala Leu Leu Thr Leu His Arg Ser Leu Asn Glu Val Val Pro 
     210                215                220
Glu Asp Gln Val His Ser Lys Ala Arg Ser Val Met Ala Lys Trp Phe 
 225                230                235                240
Thr Ile Pro Asp His Ser Arg Leu Leu Thr Lys Ser Met Met Arg Lys 
                 245                250                255
Ala Thr Ala Asp Asn Leu Ile Lys Gln Arg Glu Ala Asp Ile Gln Asn 
             260                265                270
Phe Thr Ser Phe Thr Ser Arg Asp Ser Ile Gln Lys Ser Leu His Val 
         275                280                285
Tyr Leu Glu Lys Leu Lys Gln Lys Lys Gly 
     290                295



<210> 1565
<211> 1017
<212> DNA
<213> Homo sapiens
<308> Z25820
<400> 1565

cggtcaaga  ggcgctggt  gcttctgtg  gagtcccgg  gcgcgttct  ctccgcgcg  60
gggcccggc  cccgggcgc  gccctcggg  ggacggagc  ggcggccgg  ggcggagac  120
gcgcgcggc  gttcgggag  cagcgggtg  tggtggagc  ggacgcggc  gcaggggtc  180
ctgtgatga  attcaagaa  cccccagtg  acagcctga  cctggagtt  ctgacggag  240
tggtcatca  cctggagaa  ctggagaat  acaagagct  ccgcggtgt  attctgacc  300
cggaccgcc  gggtgtctt  tcggccggc  tggacctga  ggagatgtg  gggaggagc  360
ccgcccact  cgctgggta  tggaaggcc  ttcaggagc  gtggctgcg  ttgtaccag  420
ccaacctgg  gctggtctc  gccatcaac  gagcctgcc  cgctggagg  tgcctggtg  480
ccctgacct  tgactaccg  atcctggcg  acaacccca  gtactgcat  ggactcaat  540
agacccagc  gggcatcat  gcccctttc  ggttgaaag  caccctgga  aacaccatc  600
ggcaccggg  ggcggagcg  gccctgcag  tggggctgc  cttcccgcc  gcggaggcc  660
tgcaggtgg  catagtgga  caggtggtc  cggaggagc  ggtgcagag  actgcgctg  720
cagcgatag  ccagtggat  gccattcca  accatgctc  acagctgac  aaggccatg  780
tgcgaaagg  cacggccag  cgcctggtc  cgcagcgcg  tgcggacgt  cagaacttc  840
tcagcttca  ctccaaaga  tccatccag  agtccctgc  gatgtactt  gagaggctc  900
aagaagaaa  aggctaacg  ttgggctgc  acaggctta  ggccacacg  gcccctgtg  960
gtcccaggg  ggtcttaaa  aaggtattt  tcaacttaa  aaaaaaaaa  aaaaaaa  1017



<210> 1566
<211> 302
<212> PRT
<213> Homo sapiens
<308> P42126
<400> 1566

Met Ala Leu Val Ala Ser Val Arg Val Pro Ala Arg Val Leu Leu Arg 
  1               5                  10                  15
Ala Gly Ala Arg Leu Pro Gly Ala Ala Leu Gly Arg Thr Glu Arg Ala 
             20                  25                  30
Ala Gly Gly Gly Asp Gly Ala Arg Arg Phe Gly Ser Gln Arg Val Leu 
         35                  40                  45
Val Glu Pro Asp Ala Gly Ala Gly Val Ala Val Met Lys Phe Lys Asn 
     50                  55                  60
Pro Pro Val Asn Ser Leu Ser Leu Glu Phe Leu Thr Glu Leu Val Ile 
 65                  70                  75                  80
Ser Leu Glu Lys Leu Glu Asn Asp Lys Ser Phe Arg Gly Val Ile Leu 
                 85                  90                  95
Thr Ser Asp Arg Pro Gly Val Phe Ser Ala Gly Leu Asp Leu Thr Glu 
             100                105                110
Met Cys Gly Arg Ser Pro Ala His Tyr Ala Gly Tyr Trp Lys Ala Val 
         115                120                125
Gln Glu Leu Trp Leu Arg Leu Tyr Gln Ser Asn Leu Val Leu Val Ser 
     130                135                140
Ala Ile Asn Gly Ala Cys Pro Ala Gly Gly Cys Leu Val Ala Leu Thr 
 145                150                155                160
Cys Asp Tyr Arg Ile Leu Ala Asp Asn Pro Arg Tyr Cys Ile Gly Leu 
                 165                170                175
Asn Glu Thr Gln Leu Gly Ile Ile Ala Pro Phe Trp Leu Lys Asp Thr 
             180                185                190
Leu Glu Asn Thr Ile Gly His Arg Ala Ala Glu Arg Ala Leu Gln Leu 
         195                200                205
Gly Leu Leu Phe Pro Pro Ala Glu Ala Leu Gln Val Gly Ile Val Asp 
     210                215                220
Gln Val Val Pro Glu Glu Gln Val Gln Ser Thr Ala Leu Ser Ala Ile 
 225                230                235                240
Ala Gln Trp Met Ala Ile Pro Asp His Ala Arg Gln Leu Thr Lys Ala 
                 245                250                255
Met Met Arg Lys Ala Thr Ala Ser Arg Leu Val Thr Gln Arg Asp Ala 
             260                265                270
Asp Val Gln Asn Phe Val Ser Phe Ile Ser Lys Asp Ser Ile Gln Lys 
         275                280                285
Ser Leu Gln Met Tyr Leu Glu Arg Leu Lys Glu Glu Lys Gly 
     290                295                300



<210> 1567
<211> 2602
<212> DNA
<213> Rattus norvegicus
<308> D00913
<400> 1567

ctgctgcct  cactttgcc  tggtcctcc  atggcttca  cccgtgcca  gcccatgct  60
cctctgctc  tggtcctgg  cgccgttgt  atccccggg  ctgtcggtg  tcaggtatc  120
atccatccc  cagaagcct  cctgcctcg  ggtggatcc  tgcaggtga  ctgctcttc  180
tcttgcgaa  acgagaacc  cggcctggg  ttggagact  actggatga  agacgaact  240
tcgagtgga  acaactgga  gctcttcaa  ctgagcgac  ttggggaag  cagcagacc  300
ctgtgcttt  agaactgtg  caccacgca  tcctcggct  ctgccacca  cactgtgta  360
tcgttccca  agcgagtgg  gctggatcc  ctgcccgcc  ggcagcagg  gggcaagaa  420
ctcatcctg  gctgcctgg  ggaaggcgg  gcaccgcgg  cacagctct  agtagtgct  480
ctccgtggg  atgagacac  gagccgcca  gcagtggat  gggacccca  ggagatcac  540
ttcacggtg  tggccagca  aggcgacca  ggagccaat  tctcatgct  cacagaact  600
gacctcagg  cacaagggc  gtcactgtt  aagaatgtc  ccgaggtca  gcagctccg  660
actttcgat  ttccgacta  ggtcctgaa  ctcgacacc  ctgacctcc  ggaggtggg  720
acccagcag  agttcttgt  ttccctgga  ggcctgttt  ctgcctctg  agctcagat  780
tacctggag  tgggaggcc  gatgctgac  ctggagagc  caaacagca  agattttgt  840
tcagccact  cctcagtgg  ggtgactga  aagttggac  gaaccctgc  gctgcgctg  900
gttttggag  tggcggacc  gaccctgga  atggagaag  ccttgagaa  ctacaactt  960
tcagctccc  tcctgaccc  gagccagcc  gaggtctca  aaggggacc  agtaactgt  1020
aagtgtgaa  cccacggtg  ggcacaggt  gtgcttctg  acagtactt  ccccaggcc  1080
cccacctca  agggtactt  ccccaggcc  cccacctca  agatccaat  cacactgaa  1140
gccagcccg  aggatcaca  acgacgctt  ttttgctct  cggccttgg  ggtggatgg  1200
aagtccctg  ttaaaaacc  gaccttgga  ctccatgtg  tatatggtc  tcacctgga  1260
aagaaggac  gcttgggga  ctggacctg  caagagggg  ctcagcaga  tcttacatg  1320
cagccccag  ggaatccag  ccctaatct  acctgcagc  ggaaagcag  tggtgtccc  1380
ctgcctatc  ggatggtga  gtctgtcaa  cgggagatg  atggtacct  caagtgccg  1440
gcctttagc  cccgtggga  tatcaccag  gacgtgcac  tgacagtgc  gtaccatga  1500
cagaatacc  gggtcataa  tgttggtgt  ttggtactg  tcattgcgg  cttcgtgat  1560
gtggcgtcc  tttacacct  ttaccgcca  aggaagatc  ggatataca  gttacagaa  1620
gctcaggag  aggccctaa  actcaaggt  caagccccg  ctccctgag  ccactggac  1680
ggacacctg  ctgggcccc  ctgctcttg  acagatcaa  ggacagcat  tacccctca  1740
ccacctcct  tggctgtca  aggacagga  agtggcctg  ggatgcata  ttgtagcct  1800
aggcctaag  ggactcgga  gggcaagac  gtgaactcg  gacctggac  cacctacag  1860
ctggtgggc  tgcagccaa  aaaggctga  ttccttctc  attacccct  ctgaggggc  1920
ccctacctt  ggaaggtgt  atatccggt  gacacaagc  agagaagaa  aggaacacc  1980
tgcttcctc  gacatggga  agctgggac  ctgtcccca  ctcttgttg  tgtatttat  2040
aattcagag  tctgacagt  atttattga  taccctgta  agacactag  ggagtgagc  2100
ggttaacat  taagttatt  cctagaccc  ggtgaaggg  cacaacaga  tctggggaa  2160
gatcatacg  gtttgggct  ctccacagg  cagggtgct  tcctcaaaa  agctgattt  2220
tttcacgag  catataaat  ctatgtgga  gagcagtgg  cctctgctc  tagacctct  2280
tgggacccc  gcctcctcc  acagcctgg  gtctcccag  accagcatg  gtgaccacc  2340
ccccaccta  atacattcc  acctttgtt  ccaatgtca  ccaccatgc  taaatatgg  2400
cgctcacct  tagcagctc  acaatggag  ctcatgccc  tgaaattat  gtcaatccc  2460
gcatgcctc  acccggctc  acctcaaag  gaatgcctg  gagaaaatg  tccaaccac  2520
tagaagggt  ctgcaagct  ttgtgggag  gtaggcacc  ctcccagcg  agaagcctt  2580
cctttgaat  aataaagtt  ta  2602



<210> 1568
<211> 545
<212> PRT
<213> Rattus norvegicus
<308> BAA00759
<400> 1568

Met Ala Ser Thr Arg Ala Arg Pro Met Leu Pro Leu Leu Leu Val Leu 
  1               5                  10                  15
Val Ala Val Val Ile Pro Gly Pro Val Gly Ala Gln Val Ser Ile His 
             20                  25                  30
Pro Thr Glu Ala Phe Leu Pro Arg Gly Gly Ser Val Gln Val Asn Cys 
         35                  40                  45
Ser Ser Ser Cys Glu Asp Glu Asn Leu Gly Leu Gly Leu Glu Thr Asn 
     50                  55                  60
Trp Met Lys Asp Glu Leu Ser Ser Gly His Asn Trp Lys Leu Phe Lys 
 65                  70                  75                  80
Leu Ser Asp Ile Gly Glu Asp Ser Arg Pro Leu Cys Phe Glu Asn Cys 
                 85                  90                  95
Gly Thr Thr Gln Ser Ser Ala Ser Ala Thr Ile Thr Val Tyr Ser Phe 
             100                105                110
Pro Glu Arg Val Glu Leu Asp Pro Leu Pro Ala Trp Gln Gln Val Gly 
         115                120                125
Lys Asn Leu Ile Leu Arg Cys Leu Val Glu Gly Gly Ala Pro Arg Thr 
     130                135                140
Gln Leu Ser Val Val Leu Leu Arg Gly Asn Glu Thr Leu Ser Arg Gln 
 145                150                155                160
Ala Val Asp Gly Asp Pro Lys Glu Ile Thr Phe Thr Val Leu Ala Ser 
                 165                170                175
Arg Gly Asp His Gly Ala Asn Phe Ser Cys Phe Thr Glu Leu Asp Leu 
             180                185                190
Arg Pro Gln Gly Leu Ser Leu Phe Lys Asn Val Ser Glu Val Arg Gln 
         195                200                205
Leu Arg Thr Phe Asp Leu Pro Thr Arg Val Leu Lys Leu Asp Thr Pro 
     210                215                220
Asp Leu Leu Glu Val Gly Thr Gln Gln Lys Phe Leu Cys Ser Leu Glu 
 225                230                235                240
Gly Leu Phe Pro Ala Ser Glu Ala Gln Ile Tyr Leu Glu Met Gly Gly 
                 245                250                255
Gln Met Leu Thr Leu Glu Ser Thr Asn Ser Arg Asp Phe Val Ser Ala 
             260                265                270
Thr Ala Ser Val Glu Val Thr Glu Lys Leu Asp Arg Thr Leu Gln Leu 
         275                280                285
Arg Cys Val Leu Glu Leu Ala Asp Gln Thr Leu Glu Met Glu Lys Thr 
     290                295                300
Leu Arg Ile Tyr Asn Phe Ser Ala Pro Ile Leu Thr Leu Ser Gln Pro 
 305                310                315                320
Glu Val Ser Glu Gly Asp Gln Val Thr Val Lys Cys Glu Ala His Gly 
                 325                330                335
Gly Ala Gln Val Val Leu Leu Asn Ser Thr Ser Pro Arg Pro Pro Thr 
             340                345                350
Ser Gln Gly Thr Ser Pro Arg Pro Pro Thr Ser Gln Ile Gln Phe Thr 
         355                360                365
Leu Asn Ala Ser Pro Glu Asp His Lys Arg Arg Phe Phe Cys Ser Ala 
     370                375                380
Ala Leu Glu Val Asp Gly Lys Ser Leu Phe Lys Asn Gln Thr Leu Glu 
 385                390                395                400
Leu His Val Leu Tyr Gly Pro His Leu Asp Lys Lys Asp Cys Leu Gly 
                 405                410                415
Asn Trp Thr Trp Gln Glu Gly Ser Gln Gln Thr Leu Thr Cys Gln Pro 
             420                425                430
Gln Gly Asn Pro Ala Pro Asn Leu Thr Cys Ser Arg Lys Ala Asp Gly 
         435                440                445
Val Pro Leu Pro Ile Gly Met Val Lys Ser Val Lys Arg Glu Met Asn 
     450                455                460
Gly Thr Tyr Lys Cys Arg Ala Phe Ser Ser Arg Gly Ser Ile Thr Arg 
 465                470                475                480
Asp Val His Leu Thr Val Leu Tyr His Asp Gln Asn Thr Trp Val Ile 
                 485                490                495
Ile Val Gly Val Leu Val Leu Ile Ile Ala Gly Phe Val Ile Val Ala 
             500                505                510
Ser Ile Tyr Thr Tyr Tyr Arg Gln Arg Lys Ile Arg Ile Tyr Lys Leu 
         515                520                525
Gln Lys Ala Gln Glu Glu Ala Leu Lys Leu Lys Val Gln Ala Pro Pro 
     530                535                540
Pro 
 545



<210> 1569
<211> 2986
<212> DNA
<213> Homo sapiens
<308> NM_000201
<400> 1569

gcgccccag  cgacgctga  ctcctctgc  actcagagt  gcaacctca  cctcgctat  60
gctcccagc  gcccccggc  cgcgctgcc  gcactcctg  tcctgctcg  ggctctgtt  120
ccaggacct  gcaatgccc  gacatctgt  tccccctca  aagtcatcc  gccccgggg  180
ggctccgtg  tggtgacat  cagcacctc  tgtgaccag  ccaagttgt  gggcataga  240
accccgttg  ctaaaaagg  gttgctcct  cctgggaac  accggaagg  gtatgaact  300
agcaatgtg  aagaagata  ccaaccaat  tgctattca  actgccctg  tgggcagtc  360
acagctaaa  ccttcctca  cgtgtactg  actccagaa  gggtggaac  ggcacccct  420
ccctcttgg  agccagtgg  caagaacct  accctacgc  gccaggtgg  gggtggggc  480
ccccgggcc  acctcaccg  ggtgctgct  cgtggggag  aggagctga  acgggagcc  540
gctgtgggg  agcccgctg  ggtcacgac  acggtgctg  tgaggagag  tcaccatgg  600
gccaatttc  cgtgccgca  tgaactgga  ctgcggccc  aagggctgg  gctgtttga  660
aacacctcg  ccccctacc  gctccagac  tttgtcctg  cagcgactc  cccacaact  720
gtcagcccc  gggtcctag  ggtggacac  caggggacc  tggtctgtt  cctggacgg  780
ctgttccca  tctcggagg  ccaggtcca  ctggcactg  gggaccaga  gttgaaccc  840
acagtcacc  atggcaacg  ctccttctc  gccaaggcc  cagtcagtg  gaccgcaga  900
gacgagggc  cccagcggc  gacgtgtgc  gtaatactg  ggaaccaga  ccaggagac  960
ctgcagaca  tgaccatct  cagctttcc  gcgcccaac  tgattctga  gaagccaga  1020
gtctcagaa  ggaccgagg  gacagtgaa  tgtgaggcc  accctagag  caaggtgac  1080
ctgaatggg  ttccagccc  gccactggg  ccgagggcc  agctcctgc  gaaggccac  1140
ccagaggac  acgggcgca  cttctcctg  tctgcaacc  tggaggtgg  cggccagct  1200
atacacaag  accagaccc  ggagcttcg  gtcctgtat  gcccccgac  ggacgagag  1260
gattgtccg  gaaactgga  gtggccaga  aattcccag  agactccaa  gtgccaggc  1320
tgggggaac  cattgcccg  gctcaagtg  ctaaaggat  gcactttcc  actgcccat  1380
ggggaatca  tgactgtca  tcgagatct  gagggcacc  acctctgtc  ggccaggag  1440
actcaaggg  aggtcaccc  cgaggtgac  gtgaatgtg  tctcccccc  gtatgagat  1500
gtcatcatc  ctgtggtag  agccgcagt  ataatgggc  ctgcaggcc  cagcacgta  1560
ctctataac  gccagcgga  gatcaagaa  tacagacta  aacaggccc  aaaagggac  1620
cccatgaaa  cgaacacac  agccacgcc  ccctgaacc  atcccggga  agggcctct  1680
cctcggcct  cccatattg  tggcagtgg  gccacactg  acagagtgg  agacatatg  1740
catgcagct  cacctaccg  ccctgggac  ccggaggac  gggcattgt  ctcagtcag  1800
tacaacagc  tttggggcc  tggtacctg  acacctaaa  cactaggcc  cgcatctga  1860
ctgtagtca  atgactaag  caagaggaa  gagcaagac  caagacatg  ttgatggat  1920
ttaaagtct  gcctgatga  aggggaagt  gtgggggag  catagcccc  ccatgagga  1980
atacaactg  gaaatactg  aacttgctg  ctattgggt  tgctgaggc  cacagactt  2040
cagaagaag  ggccctcca  agacatgtg  agcatcaaa  cacaaaggc  cacacttcc  2100
gacggatgc  agcttgggc  ctgctgtct  ctgacccca  cccttgatg  tatgtattt  2160
ttcatttgt  attttacca  ctatttatt  agtgtcttt  atgtaggct  aatgaacat  2220
ggtctctgg  ctcacggag  tcccagtcc  tgtcacatt  aaggtcacc  ggtacagtt  2280
tacaggttg  acactgcag  agagtgcct  gcaaaaaga  caaatgggg  tgggacttc  2340
cattggcca  cctgccttt  cccagaagg  gtgattttt  tatcggcac  aaagcacta  2400
atggactgg  aatggttca  aggttcaga  attacccag  gaggcctta  tcctccctt  2460
cccccaaaa  tgacacctt  gttagccac  tccccaccc  catacattt  tgccagtgt  2520
cacaatgac  ctcagcggt  atgtctgga  atgagtgcc  agggaatat  cccaagcta  2580
gccttgtcc  cttgtcctg  ttgcatttc  ctgggagct  gcactattg  agctccagt  2640
tcctgcagt  atcagggtc  tgcaagcag  ggggaaggg  gccaaggta  tggaggact  2700
cctcccagc  ttggaaggg  catccgcgt  tgtgtgtgt  tgtatgtgt  gacaagctc  2760
cgctctgtc  cccaggctg  agtgcagtg  tgcaatcat  gttcactgc  gtcttgacc  2820
tttgggctc  agtgatcct  ccacctcag  ctcctgagt  gctgggacc  taggctcac  2880
acaccacac  tggcaaatt  gattttttt  ttttttttc  gagacgggg  ctcgcaaca  2940
tgcccagac  tcctttgtg  tagttaata  agctttctc  actgcc  2986



<210> 1570
<211> 532
<212> PRT
<213> Homo sapiens
<308> P05362
<400> 1570

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
  1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
             20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
         35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
     50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
 65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                 85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
             100                105                110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
         115                120                125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
     130                135                140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
 145                150                155                160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                 165                170                175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
             180                185                190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
         195                200                205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
     210                215                220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
 225                230                235                240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                 245                250                255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
             260                265                270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
         275                280                285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
     290                295                300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
 305                310                315                320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                 325                330                335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
             340                345                350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
         355                360                365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
     370                375                380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
 385                390                395                400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                 405                410                415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
             420                425                430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
         435                440                445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
     450                455                460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
 465                470                475                480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                 485                490                495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
             500                505                510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
         515                520                525
Ala Thr Pro Pro 
     530



<210> 1571
<211> 2602
<212> DNA
<213> Rattus norvegicus
<308> D00913
<400> 1571

ctgctgcct  cactttgcc  tggtcctcc  atggcttca  cccgtgcca  gcccatgct  60
cctctgctc  tggtcctgg  cgccgttgt  atccccggg  ctgtcggtg  tcaggtatc  120
atccatccc  cagaagcct  cctgcctcg  ggtggatcc  tgcaggtga  ctgctcttc  180
tcttgcgaa  acgagaacc  cggcctggg  ttggagact  actggatga  agacgaact  240
tcgagtgga  acaactgga  gctcttcaa  ctgagcgac  ttggggaag  cagcagacc  300
ctgtgcttt  agaactgtg  caccacgca  tcctcggct  ctgccacca  cactgtgta  360
tcgttccca  agcgagtgg  gctggatcc  ctgcccgcc  ggcagcagg  gggcaagaa  420
ctcatcctg  gctgcctgg  ggaaggcgg  gcaccgcgg  cacagctct  agtagtgct  480
ctccgtggg  atgagacac  gagccgcca  gcagtggat  gggacccca  ggagatcac  540
ttcacggtg  tggccagca  aggcgacca  ggagccaat  tctcatgct  cacagaact  600
gacctcagg  cacaagggc  gtcactgtt  aagaatgtc  ccgaggtca  gcagctccg  660
actttcgat  ttccgacta  ggtcctgaa  ctcgacacc  ctgacctcc  ggaggtggg  720
acccagcag  agttcttgt  ttccctgga  ggcctgttt  ctgcctctg  agctcagat  780
tacctggag  tgggaggcc  gatgctgac  ctggagagc  caaacagca  agattttgt  840
tcagccact  cctcagtgg  ggtgactga  aagttggac  gaaccctgc  gctgcgctg  900
gttttggag  tggcggacc  gaccctgga  atggagaag  ccttgagaa  ctacaactt  960
tcagctccc  tcctgaccc  gagccagcc  gaggtctca  aaggggacc  agtaactgt  1020
aagtgtgaa  cccacggtg  ggcacaggt  gtgcttctg  acagtactt  ccccaggcc  1080
cccacctca  agggtactt  ccccaggcc  cccacctca  agatccaat  cacactgaa  1140
gccagcccg  aggatcaca  acgacgctt  ttttgctct  cggccttgg  ggtggatgg  1200
aagtccctg  ttaaaaacc  gaccttgga  ctccatgtg  tatatggtc  tcacctgga  1260
aagaaggac  gcttgggga  ctggacctg  caagagggg  ctcagcaga  tcttacatg  1320
cagccccag  ggaatccag  ccctaatct  acctgcagc  ggaaagcag  tggtgtccc  1380
ctgcctatc  ggatggtga  gtctgtcaa  cgggagatg  atggtacct  caagtgccg  1440
gcctttagc  cccgtggga  tatcaccag  gacgtgcac  tgacagtgc  gtaccatga  1500
cagaatacc  gggtcataa  tgttggtgt  ttggtactg  tcattgcgg  cttcgtgat  1560
gtggcgtcc  tttacacct  ttaccgcca  aggaagatc  ggatataca  gttacagaa  1620
gctcaggag  aggccctaa  actcaaggt  caagccccg  ctccctgag  ccactggac  1680
ggacacctg  ctgggcccc  ctgctcttg  acagatcaa  ggacagcat  tacccctca  1740
ccacctcct  tggctgtca  aggacagga  agtggcctg  ggatgcata  ttgtagcct  1800
aggcctaag  ggactcgga  gggcaagac  gtgaactcg  gacctggac  cacctacag  1860
ctggtgggc  tgcagccaa  aaaggctga  ttccttctc  attacccct  ctgaggggc  1920
ccctacctt  ggaaggtgt  atatccggt  gacacaagc  agagaagaa  aggaacacc  1980
tgcttcctc  gacatggga  agctgggac  ctgtcccca  ctcttgttg  tgtatttat  2040
aattcagag  tctgacagt  atttattga  taccctgta  agacactag  ggagtgagc  2100
ggttaacat  taagttatt  cctagaccc  ggtgaaggg  cacaacaga  tctggggaa  2160
gatcatacg  gtttgggct  ctccacagg  cagggtgct  tcctcaaaa  agctgattt  2220
tttcacgag  catataaat  ctatgtgga  gagcagtgg  cctctgctc  tagacctct  2280
tgggacccc  gcctcctcc  acagcctgg  gtctcccag  accagcatg  gtgaccacc  2340
ccccaccta  atacattcc  acctttgtt  ccaatgtca  ccaccatgc  taaatatgg  2400
cgctcacct  tagcagctc  acaatggag  ctcatgccc  tgaaattat  gtcaatccc  2460
gcatgcctc  acccggctc  acctcaaag  gaatgcctg  gagaaaatg  tccaaccac  2520
tagaagggt  ctgcaagct  ttgtgggag  gtaggcacc  ctcccagcg  agaagcctt  2580
cctttgaat  aataaagtt  ta  2602



<210> 1572
<211> 545
<212> PRT
<213> Rattus norvegicus
<308> BAA00759
<400> 1572

Met Ala Ser Thr Arg Ala Arg Pro Met Leu Pro Leu Leu Leu Val Leu 
  1               5                  10                  15
Val Ala Val Val Ile Pro Gly Pro Val Gly Ala Gln Val Ser Ile His 
             20                  25                  30
Pro Thr Glu Ala Phe Leu Pro Arg Gly Gly Ser Val Gln Val Asn Cys 
         35                  40                  45
Ser Ser Ser Cys Glu Asp Glu Asn Leu Gly Leu Gly Leu Glu Thr Asn 
     50                  55                  60
Trp Met Lys Asp Glu Leu Ser Ser Gly His Asn Trp Lys Leu Phe Lys 
 65                  70                  75                  80
Leu Ser Asp Ile Gly Glu Asp Ser Arg Pro Leu Cys Phe Glu Asn Cys 
                 85                  90                  95
Gly Thr Thr Gln Ser Ser Ala Ser Ala Thr Ile Thr Val Tyr Ser Phe 
             100                105                110
Pro Glu Arg Val Glu Leu Asp Pro Leu Pro Ala Trp Gln Gln Val Gly 
         115                120                125
Lys Asn Leu Ile Leu Arg Cys Leu Val Glu Gly Gly Ala Pro Arg Thr 
     130                135                140
Gln Leu Ser Val Val Leu Leu Arg Gly Asn Glu Thr Leu Ser Arg Gln 
 145                150                155                160
Ala Val Asp Gly Asp Pro Lys Glu Ile Thr Phe Thr Val Leu Ala Ser 
                 165                170                175
Arg Gly Asp His Gly Ala Asn Phe Ser Cys Phe Thr Glu Leu Asp Leu 
             180                185                190
Arg Pro Gln Gly Leu Ser Leu Phe Lys Asn Val Ser Glu Val Arg Gln 
         195                200                205
Leu Arg Thr Phe Asp Leu Pro Thr Arg Val Leu Lys Leu Asp Thr Pro 
     210                215                220
Asp Leu Leu Glu Val Gly Thr Gln Gln Lys Phe Leu Cys Ser Leu Glu 
 225                230                235                240
Gly Leu Phe Pro Ala Ser Glu Ala Gln Ile Tyr Leu Glu Met Gly Gly 
                 245                250                255
Gln Met Leu Thr Leu Glu Ser Thr Asn Ser Arg Asp Phe Val Ser Ala 
             260                265                270
Thr Ala Ser Val Glu Val Thr Glu Lys Leu Asp Arg Thr Leu Gln Leu 
         275                280                285
Arg Cys Val Leu Glu Leu Ala Asp Gln Thr Leu Glu Met Glu Lys Thr 
     290                295                300
Leu Arg Ile Tyr Asn Phe Ser Ala Pro Ile Leu Thr Leu Ser Gln Pro 
 305                310                315                320
Glu Val Ser Glu Gly Asp Gln Val Thr Val Lys Cys Glu Ala His Gly 
                 325                330                335
Gly Ala Gln Val Val Leu Leu Asn Ser Thr Ser Pro Arg Pro Pro Thr 
             340                345                350
Ser Gln Gly Thr Ser Pro Arg Pro Pro Thr Ser Gln Ile Gln Phe Thr 
         355                360                365
Leu Asn Ala Ser Pro Glu Asp His Lys Arg Arg Phe Phe Cys Ser Ala 
     370                375                380
Ala Leu Glu Val Asp Gly Lys Ser Leu Phe Lys Asn Gln Thr Leu Glu 
 385                390                395                400
Leu His Val Leu Tyr Gly Pro His Leu Asp Lys Lys Asp Cys Leu Gly 
                 405                410                415
Asn Trp Thr Trp Gln Glu Gly Ser Gln Gln Thr Leu Thr Cys Gln Pro 
             420                425                430
Gln Gly Asn Pro Ala Pro Asn Leu Thr Cys Ser Arg Lys Ala Asp Gly 
         435                440                445
Val Pro Leu Pro Ile Gly Met Val Lys Ser Val Lys Arg Glu Met Asn 
     450                455                460
Gly Thr Tyr Lys Cys Arg Ala Phe Ser Ser Arg Gly Ser Ile Thr Arg 
 465                470                475                480
Asp Val His Leu Thr Val Leu Tyr His Asp Gln Asn Thr Trp Val Ile 
                 485                490                495
Ile Val Gly Val Leu Val Leu Ile Ile Ala Gly Phe Val Ile Val Ala 
             500                505                510
Ser Ile Tyr Thr Tyr Tyr Arg Gln Arg Lys Ile Arg Ile Tyr Lys Leu 
         515                520                525
Gln Lys Ala Gln Glu Glu Ala Leu Lys Leu Lys Val Gln Ala Pro Pro 
     530                535                540
Pro 
 545



<210> 1573
<211> 2986
<212> DNA
<213> Homo sapiens
<308> NM_000201
<400> 1573

gcgccccag  cgacgctga  ctcctctgc  actcagagt  gcaacctca  cctcgctat  60
gctcccagc  gcccccggc  cgcgctgcc  gcactcctg  tcctgctcg  ggctctgtt  120
ccaggacct  gcaatgccc  gacatctgt  tccccctca  aagtcatcc  gccccgggg  180
ggctccgtg  tggtgacat  cagcacctc  tgtgaccag  ccaagttgt  gggcataga  240
accccgttg  ctaaaaagg  gttgctcct  cctgggaac  accggaagg  gtatgaact  300
agcaatgtg  aagaagata  ccaaccaat  tgctattca  actgccctg  tgggcagtc  360
acagctaaa  ccttcctca  cgtgtactg  actccagaa  gggtggaac  ggcacccct  420
ccctcttgg  agccagtgg  caagaacct  accctacgc  gccaggtgg  gggtggggc  480
ccccgggcc  acctcaccg  ggtgctgct  cgtggggag  aggagctga  acgggagcc  540
gctgtgggg  agcccgctg  ggtcacgac  acggtgctg  tgaggagag  tcaccatgg  600
gccaatttc  cgtgccgca  tgaactgga  ctgcggccc  aagggctgg  gctgtttga  660
aacacctcg  ccccctacc  gctccagac  tttgtcctg  cagcgactc  cccacaact  720
gtcagcccc  gggtcctag  ggtggacac  caggggacc  tggtctgtt  cctggacgg  780
ctgttccca  tctcggagg  ccaggtcca  ctggcactg  gggaccaga  gttgaaccc  840
acagtcacc  atggcaacg  ctccttctc  gccaaggcc  cagtcagtg  gaccgcaga  900
gacgagggc  cccagcggc  gacgtgtgc  gtaatactg  ggaaccaga  ccaggagac  960
ctgcagaca  tgaccatct  cagctttcc  gcgcccaac  tgattctga  gaagccaga  1020
gtctcagaa  ggaccgagg  gacagtgaa  tgtgaggcc  accctagag  caaggtgac  1080
ctgaatggg  ttccagccc  gccactggg  ccgagggcc  agctcctgc  gaaggccac  1140
ccagaggac  acgggcgca  cttctcctg  tctgcaacc  tggaggtgg  cggccagct  1200
atacacaag  accagaccc  ggagcttcg  gtcctgtat  gcccccgac  ggacgagag  1260
gattgtccg  gaaactgga  gtggccaga  aattcccag  agactccaa  gtgccaggc  1320
tgggggaac  cattgcccg  gctcaagtg  ctaaaggat  gcactttcc  actgcccat  1380
ggggaatca  tgactgtca  tcgagatct  gagggcacc  acctctgtc  ggccaggag  1440
actcaaggg  aggtcaccc  cgaggtgac  gtgaatgtg  tctcccccc  gtatgagat  1500
gtcatcatc  ctgtggtag  agccgcagt  ataatgggc  ctgcaggcc  cagcacgta  1560
ctctataac  gccagcgga  gatcaagaa  tacagacta  aacaggccc  aaaagggac  1620
cccatgaaa  cgaacacac  agccacgcc  ccctgaacc  atcccggga  agggcctct  1680
cctcggcct  cccatattg  tggcagtgg  gccacactg  acagagtgg  agacatatg  1740
catgcagct  cacctaccg  ccctgggac  ccggaggac  gggcattgt  ctcagtcag  1800
tacaacagc  tttggggcc  tggtacctg  acacctaaa  cactaggcc  cgcatctga  1860
ctgtagtca  atgactaag  caagaggaa  gagcaagac  caagacatg  ttgatggat  1920
ttaaagtct  gcctgatga  aggggaagt  gtgggggag  catagcccc  ccatgagga  1980
atacaactg  gaaatactg  aacttgctg  ctattgggt  tgctgaggc  cacagactt  2040
cagaagaag  ggccctcca  agacatgtg  agcatcaaa  cacaaaggc  cacacttcc  2100
gacggatgc  agcttgggc  ctgctgtct  ctgacccca  cccttgatg  tatgtattt  2160
ttcatttgt  attttacca  ctatttatt  agtgtcttt  atgtaggct  aatgaacat  2220
ggtctctgg  ctcacggag  tcccagtcc  tgtcacatt  aaggtcacc  ggtacagtt  2280
tacaggttg  acactgcag  agagtgcct  gcaaaaaga  caaatgggg  tgggacttc  2340
cattggcca  cctgccttt  cccagaagg  gtgattttt  tatcggcac  aaagcacta  2400
atggactgg  aatggttca  aggttcaga  attacccag  gaggcctta  tcctccctt  2460
cccccaaaa  tgacacctt  gttagccac  tccccaccc  catacattt  tgccagtgt  2520
cacaatgac  ctcagcggt  atgtctgga  atgagtgcc  agggaatat  cccaagcta  2580
gccttgtcc  cttgtcctg  ttgcatttc  ctgggagct  gcactattg  agctccagt  2640
tcctgcagt  atcagggtc  tgcaagcag  ggggaaggg  gccaaggta  tggaggact  2700
cctcccagc  ttggaaggg  catccgcgt  tgtgtgtgt  tgtatgtgt  gacaagctc  2760
cgctctgtc  cccaggctg  agtgcagtg  tgcaatcat  gttcactgc  gtcttgacc  2820
tttgggctc  agtgatcct  ccacctcag  ctcctgagt  gctgggacc  taggctcac  2880
acaccacac  tggcaaatt  gattttttt  ttttttttc  gagacgggg  ctcgcaaca  2940
tgcccagac  tcctttgtg  tagttaata  agctttctc  actgcc  2986



<210> 1574
<211> 532
<212> PRT
<213> Homo sapiens
<308> P05362
<400> 1574

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
  1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
             20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
         35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
     50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
 65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                 85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
             100                105                110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
         115                120                125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
     130                135                140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
 145                150                155                160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                 165                170                175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
             180                185                190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
         195                200                205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
     210                215                220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
 225                230                235                240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                 245                250                255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
             260                265                270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
         275                280                285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
     290                295                300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
 305                310                315                320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                 325                330                335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
             340                345                350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
         355                360                365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
     370                375                380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
 385                390                395                400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                 405                410                415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
             420                425                430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
         435                440                445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
     450                455                460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
 465                470                475                480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                 485                490                495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
             500                505                510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
         515                520                525
Ala Thr Pro Pro 
     530



<210> 1575
<211> 2130
<212> DNA
<213> Rattus norvegicus
<308> D10392
<400> 1575

gcagccggc  cctactgcc  ctcccgcga  catgaagga  cgaacccag  agctccgca  60
ggccaagga  agcgatgac  acgatgatg  cactgtcac  gtggaccga  accgcttca  120
ggatgagtt  tttgaacag  tggaagaga  ccggggctt  attgacaag  ttgctgaaa  180
cgtggagga  gtgaagagg  aacacagcg  catcctggc  tccccgaac  ccgatgaga  240
gaccaagga  gaactggag  agctcatgt  ggacattaa  aagacagcg  acaaagttc  300
ctccaagct  aagagcatc  agcagagca  cgagcagga  gaaggtctg  accgctcgt  360
ggcggacct  aggatccgg  agacgcagc  ttccacgct  tcccgaaag  ttgtggagg  420
catgtccga  tacaacgcc  ctcagtcag  ctaccgaga  cgctgcaaa  ggcgcatcc  480
gaggcagct  gagatcact  gccggacca  gaccagtga  gagttggaa  acatgctgg  540
gagtgggaa  cccgccatc  ttgcctctg  gatcatcat  gactccagc  tctcgaagc  600
ggccctcag  gagatcgag  ccaggcaca  tgagatcat  aagttggag  acagcatcc  660
ggagctaca  gatatgttc  tggacatgg  catgctggt  gagagccag  gggagatga  720
tgacaggat  gagtacaat  tggaacacg  tgtggacta  gtggagagg  ccgtgtctg  780
caccaagaa  gccgtcaag  accagagca  ggcacgcag  aagaagatc  tgatcatca  840
ttgctgtgt  attctgggc  tcatcatcg  ctccaccat  gggggcatc  ttggataga  900
accacccca  ccacggctc  attctggat  ggtctccct  aggaggccc  tggctgctg  960
acctagctg  gttgccctc  ccactcctg  cttctggct  ggagtcctt  tccctccca  1020
ccaacaccg  tccctctct  ccatgaggc  cccgtcccc  ccaccctgc  ccaagccgt  1080
tcgtgtgca  gatcttgtg  cagtgtgtg  ctgtacagg  ggcagaggg  agcaggatc  1140
ggaacagcc  gaggggctg  gtacaggcc  gtgtgggca  gactcgggc  ctggccagg  1200
ccgccttcc  tcaggcctg  ggcctacgc  tccctggga  tcaggctcc  ttctggacc  1260
caaccttgc  ctcactcgc  ctgccctct  gcttcctca  ctctcccca  catgccaag  1320
cacctggag  gtggggacc  gctggtcac  tggtgctgc  tttcaggtt  ggggtgggg  1380
cagctcagc  ctgagtctt  gttagctgc  cactgccag  atgctcagg  tgccacggc  1440
gctggtgtg  taggagcac  cagtacccc  ctttggcaa  gcctgacag  gtctctggc  1500
tcagctgcc  ttaccacag  cctgggagt  ctgttcctg  gctgggcct  agcctagtg  1560
tcctttgct  agaagctca  tggtgccat  tccagcctt  ctctgagct  gagaggtgg  1620
gcaggccat  gtcctctgc  cacagtctc  aacgggcat  ttaagtcgt  gccggagtt  1680
catgttagg  acagcggtt  cctgctccc  ttctgctct  aaaagccag  tgtcacttt  1740
ggcctgcag  ctcaccctg  cctgtctcc  attgatgtg  cacgtggtg  caggtgtac  1800
ggatgcagt  ttcagcagc  agctgggga  ggggctccc  actttcctc  cctgccaac  1860
tggggcttc  cagagtcaa  aatgtaccc  catgcccca  gaccccttt  tcatccaca  1920
gcaaggagt  tgcatgcga  tgcatgcag  gggagctgg  gccgtgtct  tgtgcccct  1980
cccctccgc  ttgctcctg  ccagtgact  accactgtc  gtgctgcct  ctctcatgg  2040
cacttccct  taccccgtc  ccaaaggtc  cggtacaac  agctgccca  tttgtgaga  2100
ttttatgta  aataaacat  tgtatctgga  2130



<210> 1576
<211> 288
<212> PRT
<213> Rattus norvegicus
<308> P32851
<400> 1576

Met Lys Asp Arg Thr Gln Glu Leu Arg Thr Ala Lys Asp Ser Asp Asp 
  1               5                  10                  15
Asp Asp Asp Val Thr Val Thr Val Asp Arg Asp Arg Phe Met Asp Glu 
             20                  25                  30
Phe Phe Glu Gln Val Glu Glu Ile Arg Gly Phe Ile Asp Lys Ile Ala 
         35                  40                  45
Glu Asn Val Glu Glu Val Lys Arg Lys His Ser Ala Ile Leu Ala Ser 
     50                  55                  60
Pro Asn Pro Asp Glu Lys Thr Lys Glu Glu Leu Glu Glu Leu Met Ser 
 65                  70                  75                  80
Asp Ile Lys Lys Thr Ala Asn Lys Val Arg Ser Lys Leu Lys Ser Ile 
                 85                  90                  95
Glu Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser Ser Ala Asp 
             100                105                110
Leu Arg Ile Arg Lys Thr Gln His Ser Thr Leu Ser Arg Lys Phe Val 
         115                120                125
Glu Val Met Ser Glu Tyr Asn Ala Thr Gln Ser Asp Tyr Arg Glu Arg 
     130                135                140
Cys Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr 
 145                150                155                160
Thr Ser Glu Glu Leu Glu Asp Met Leu Glu Ser Gly Asn Pro Ala Ile 
                 165                170                175
Phe Ala Ser Gly Ile Ile Met Asp Ser Ser Ile Ser Lys Gln Ala Leu 
             180                185                190
Ser Glu Ile Glu Thr Arg His Ser Glu Ile Ile Lys Leu Glu Asn Ser 
         195                200                205
Ile Arg Glu Leu His Asp Met Phe Met Asp Met Ala Met Leu Val Glu 
     210                215                220
Ser Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ala 
 225                230                235                240
Val Asp Tyr Val Glu Arg Ala Val Ser Asp Thr Lys Lys Ala Val Lys 
                 245                250                255
Tyr Gln Ser Lys Ala Arg Arg Lys Lys Ile Met Ile Ile Ile Cys Cys 
             260                265                270
Val Ile Leu Gly Ile Ile Ile Ala Ser Thr Ile Gly Gly Ile Phe Gly 
         275                280                285



<210> 1577
<211> 2074
<212> DNA
<213> Homo sapiens
<308> BC003011
<400> 1577

agccggcgc  gctgccact  ccgggagca  gaaggaccg  acccaggag  tccgcacgg  60
caaggacag  gatgatgat  atgatgtcg  tgtcaccgt  gaccgagac  gcttcatgg  120
tgagttctt  gagcaggtg  aggagattc  aggcttcat  gacaagatc  cagagaacg  180
ggaggaggt  aagcggaag  acagtgcca  cctggcatc  cccaacccc  acgagaaga  240
gaaggagga  ctggaagaa  tcatgtccg  cataaagaa  acagcaaac  aagttcgtt  300
caagttaaa  agcatcgag  agtccatcg  gcaagagga  ggcctgaac  gctcctccg  360
tgacctgag  atccggaag  cacagcact  cacgctgtc  agaaagttt  tggaggtca  420
gtcggagta  aacgccacg  agtccgact  ccgcgagcg  tgcaaaggc  gcatccaga  480
gcagctgga  atcaccggc  ggaccacga  cagtgagga  ctggaggac  tgctggaga  540
tgggaaccc  gccatcttt  cctctggga  catcatgga  tccagcatc  cgaagcagg  600
tctgagcga  attgagacg  ggcacagtg  gatcatcaa  ctggagaac  gcatccgtg  660
gctacacga  atgttcatg  acatggcca  gctcgtgga  agccagact  tgtggagag  720
gccgtgtct  acaccaaga  ggccgtcaa  taccagagc  aggcgcgcc  gaagaaaat  780
atgatcatc  tctgctgtg  gatcctggg  atcgtcatc  cctccactg  tgggggcat  840
ttcgcctag  agccaccca  actgccact  cactccagg  gggccactc  aaggaggcc  900
tggctgctg  cacctggct  ggctgccct  ccaaccccc  cctctggct  agagcaccc  960
ccctcccgg  ccccatgct  ccttctctg  catgggccc  ccgtccccg  cccgtgtcg  1020
gtgcatgat  tctgtgagt  tgcgtctgt  cgggaagag  cagagggag  cagccagcg  1080
ggcgtgatg  agtgtgcac  gcgaggagc  gacccaggc  gggccgcca  ggtgacaca  1140
gccaccctt  cttgccttc  gtaactcgg  gggcccagg  tctgctctt  cctggggac  1200
ctaacctcg  ctccagctg  cctgccctg  cctctccag  tgtccccac  agcagagcc  1260
tgaggggtg  ggaccagct  gccacatgg  gctgctttt  aggttaggg  agaggtggc  1320
ctgagggac  gcccagctc  gagtctcag  cgctgatca  tgccaggga  gctcaggct  1380
ccatggctc  aggctccct  ccctgccta  gggcaaagt  catcgggtc  tgggcctca  1440
cttcccttc  cacattcct  cggccccag  agcaacccc  tgggctagg  ctgacccca  1500
gtgtccctc  ggaaggggc  ggctggtgc  ctatttcca  ccaccccag  agctaggga  1560
gcaaagcag  ctgcagtca  tccctcaag  cagcgttgc  tgtttggga  ggtggctcc  1620
gttgtcttg  gctctggga  gtcagatgt  atttcaggc  tgcagtctc  tcctgccct  1680
gccatcctc  catcgatgt  ccacgtggg  gtcacgtgt  ccagatgca  tattcggca  1740
ccagccggg  agggctacc  cctcctcct  accaccttg  ggcttctca  gggaaatgt  1800
cccccgccc  aggaccctc  cccttgtgg  caggcaggg  gatgcatgc  agtgcatgc  1860
gcaggggat  gggccgtgt  cgtgtgccc  accctccct  ggctttact  ctgcccagt  1920
actgtgacc  ctgtccgtg  tgccttctt  aacagcgat  ccccccaac  ccttcacca  1980
aggtcttgg  acaaccagc  gcccatttt  tgaaatttt  atgtagaat  aacatttgt  2040
tctgtaaaa  aaaaaaaaa  aaaaaaaaa  aaaa  2074



<210> 1578
<211> 288
<212> PRT
<213> Homo sapiens
<308> Q16623
<400> 1578

Met Lys Asp Arg Thr Gln Glu Leu Arg Thr Ala Lys Asp Ser Asp Asp 
  1               5                  10                  15
Asp Asp Asp Val Ala Val Thr Val Asp Arg Asp Arg Phe Met Asp Glu 
             20                  25                  30
Phe Phe Glu Gln Val Glu Glu Ile Arg Gly Phe Ile Asp Lys Ile Ala 
         35                  40                  45
Glu Asn Val Glu Glu Val Lys Arg Lys His Ser Ala Ile Leu Ala Ser 
     50                  55                  60
Pro Asn Pro Asp Glu Lys Thr Lys Glu Glu Leu Glu Glu Leu Met Ser 
 65                  70                  75                  80
Asp Ile Lys Lys Thr Ala Asn Lys Val Arg Ser Lys Leu Lys Ser Ile 
                 85                  90                  95
Glu Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser Ser Ala Asp 
             100                105                110
Leu Arg Ile Arg Lys Thr Gln His Ser Thr Leu Ser Arg Lys Phe Val 
         115                120                125
Glu Val Met Ser Glu Tyr Asn Ala Thr Gln Ser Asp Tyr Arg Glu Arg 
     130                135                140
Cys Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr 
 145                150                155                160
Thr Ser Glu Glu Leu Glu Asp Met Leu Glu Ser Gly Asn Pro Ala Ile 
                 165                170                175
Phe Ala Ser Gly Ile Ile Met Asp Ser Ser Ile Ser Lys Gln Ala Leu 
             180                185                190
Ser Glu Ile Glu Thr Arg His Ser Glu Ile Ile Lys Leu Glu Asn Ser 
         195                200                205
Ile Arg Glu Leu His Asp Met Phe Met Asp Met Ala Met Leu Val Glu 
     210                215                220
Ser Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ala 
 225                230                235                240
Val Asp Tyr Val Glu Arg Ala Val Ser Asp Thr Lys Lys Ala Val Lys 
                 245                250                255
Tyr Gln Ser Lys Ala Arg Arg Lys Lys Ile Met Ile Ile Ile Cys Cys 
             260                265                270
Val Ile Leu Gly Ile Val Ile Ala Ser Thr Val Gly Gly Ile Phe Ala 
         275                280                285



<210> 1579
<211> 2064
<212> DNA
<213> Rattus norvegicus
<308> D10587
<400> 1579

cccagcacc  gcgatcgcg  gggctctgt  ctccgaggg  cgtgctcgc  tggtgccta  60
tccagggct  tgtacaccg  gcgggcggc  gctgagccc  caccaggag  gcgcgggag  120
cgcagggcc  tggagcttt  ggcgactgc  acgcggcct  ggccgaggc  cttccttgc  180
cgccgttct  tcgcgggcc  ggcccgtga  ccgctcaca  tatggcccg  tgctgcttc  240
acacggcgg  gacactgtc  ctgctgctg  tggtgacca  tgtcacgct  ctagtggct  300
gagtctttc  gaaggcagt  gaccagacg  tcgagaaga  tatggtatt  caaaatggt  360
ccaaggtct  tgattcctg  gagaagccc  ctctacctg  gtacatcca  ttttatttc  420
tcaatgtca  caatccaga  gagatcctc  aaggagaaa  ccccctgct  gaagaagtg  480
ggccgtaca  ctacaggga  ctcaggaac  aggcaaacg  tcagtttgg  gaaaatgga  540
caaccatat  tgccgtcac  aataaggca  atatttttg  acgaaacca  tctgttgga  600
accctaccg  tgacttgat  agaacaata  atattcctc  gttgactgt  gtggaaatg  660
cccagcagc  cttcctcag  gagatcatc  aggccatgc  gaaagctta  cagcagacg  720
tgtttgtca  tcacactgt  catgaactg  tctggggct  caaagatga  gtcttgtcg  780
tcgtccata  tttcagacc  gacgtctcc  ctaactttg  cctgttcta  gagagaaat  840
gaactaatg  tggggagta  gtttttctg  ctggagagg  caattacct  aactttaca  900
aaattgtgg  gtggaatgg  aaaacgtcg  tggactggt  gacgacgga  acgtgcaat  960
tgatcaacg  gacagacgg  gattctttt  acccattaa  aagcaagga  gagaccctg  1020
acatcttcc  atctgactt  tgcaggtcc  tctatataa  tttcagtag  tttgagaac  1080
tagaaggac  gcctgcttt  cggtataag  tgcctgcag  aatactagc  aattcctcc  1140
aaaacgctg  cttctgtat  cccgaggga  actgcatgg  cgcgggagt  ctgaacgtc  1200
gcatttgca  gaatggtgc  cccattatc  tgtctttcc  acactttta  caagccgac  1260
agaagttcg  ttcggccat  aaaggcatg  gtccaaaca  ggaagaaca  gagtcattt  1320
tggacatta  tcctttgac  ggaattatt  taagagggg  caagagatt  caaatcaac  1380
cgtacgtta  gaagctgga  gactttgtg  aaacgggaa  cattaggac  atggttttc  1440
cagtgatgt  tctcaatga  agtgttctc  ttgacaaag  gactgcaag  caactgaag  1500
ctgtgatta  cacaacttt  attgtcacc  acataccct  catcatcat  gcactgggc  1560
tgttctttg  cttgatttt  acgtggctg  cgtgtcgag  acaggggtc  acggatgag  1620
gaactgcag  tgaaagggc  cccctcata  ggacctaat  ggacttacc  gttgcctga  1680
cttggtgag  gaatgtgag  actgacctg  cctggacca  gacagggaa  agcctgcat  1740
ctcacgggc  cctggcctg  caagaaggg  gtgaagccg  agcactggc  cgcgagaag  1800
ccctcctgg  cagagggga  cgagcaggt  acatggctg  caattacgc  ttataaaat  1860
atgtctctg  aactgtgtc  atgtgtctt  gggagtatt  aataaattg  gtagaaacc  1920
tttgtgatt  ggctctggg  gctgtgggg  tttgtaacc  ctgttgtag  tacagtgtc  1980
gagtcactt  ttaatgtta  cttggcctg  cccgattca  tatgcctca  tctccaaac  2040
ttgtgttta  aatatgaaa  aaaa  2064



<210> 1580
<211> 477
<212> PRT
<213> Rattus norvegicus
<308> BAA01444
<400> 1580

Ala Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu Leu 
  1               5                  10                  15
Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala Val 
             20                  25                  30
Asp Gln Thr Ile Glu Lys Asn Met Val Leu Gln Asn Gly Thr Lys Val 
         35                  40                  45
Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Ile Gln Phe Tyr 
     50                  55                  60
Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Gln Gly Glu Ile Pro 
 65                  70                  75                  80
Leu Leu Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn Lys 
                 85                  90                  95
Ala Asn Val Gln Phe Gly Glu Asn Gly Thr Thr Ile Ser Ala Val Thr 
             100                105                110
Asn Lys Ala Tyr Ile Phe Glu Arg Asn Gln Ser Val Gly Asp Pro Thr 
         115                120                125
Val Asp Leu Ile Arg Thr Ile Asn Ile Pro Leu Leu Thr Val Val Glu 
     130                135                140
Met Ala Gln Gln Pro Phe Leu Arg Glu Ile Ile Glu Ala Met Leu Lys 
 145                150                155                160
Ala Tyr Gln Gln Thr Leu Phe Val Thr His Thr Val His Glu Leu Leu 
                 165                170                175
Trp Gly Tyr Lys Asp Glu Val Leu Ser Leu Val His Ile Phe Arg Pro 
             180                185                190
Asp Val Ser Pro Asn Phe Gly Leu Phe Tyr Glu Arg Asn Gly Thr Asn 
         195                200                205
Asp Gly Glu Tyr Val Phe Leu Thr Gly Glu Asp Asn Tyr Leu Asn Phe 
     210                215                220
Thr Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp Thr 
 225                230                235                240
Thr Asp Thr Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe His 
                 245                250                255
Pro Leu Ile Ser Lys Asp Glu Thr Leu Tyr Ile Phe Pro Ser Asp Phe 
             260                265                270
Cys Arg Ser Val Tyr Ile Thr Phe Ser Ser Phe Glu Asn Val Glu Gly 
         275                280                285
Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn Ser 
     290                295                300
Ser Glu Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Met Asp Ala 
 305                310                315                320
Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile Met 
                 325                330                335
Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Lys Phe Val Ser Ala Ile 
             340                345                350
Lys Gly Met Arg Pro Asn Lys Glu Glu His Glu Ser Phe Val Asp Ile 
         355                360                365
Asn Pro Leu Thr Gly Ile Ile Leu Arg Gly Ala Lys Arg Phe Gln Ile 
     370                375                380
Asn Thr Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly Asn Ile 
 385                390                395                400
Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val Leu Ile 
                 405                410                415
Asp Lys Glu Thr Ala Ser Gln Leu Lys Ser Val Ile Asn Thr Thr Leu 
             420                425                430
Ile Val Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe Phe 
         435                440                445
Gly Leu Ile Phe Thr Trp Leu Ala Cys Arg Gly Gln Gly Ser Thr Asp 
     450                455                460
Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 
 465                470                475



<210> 1581
<211> 2329
<212> DNA
<213> Homo sapiens
<308> D12676
<400> 1581

cacggctgc  cggcgaagg  aaccgaaac  gagtccggg  ccgtccctc  gcggcccca  60
ccgcccggt  cacccgggg  cgcgctcgc  aggccgcgg  gccagagct  cgcgcacga  120
ccgtgcgcg  gagggcgtg  gcgttgcgc  gaagggtcc  gagtcttcg  cgcctctgc  180
gcggctcct  cctccttgc  gttggatcc  tggcgggtg  ggcccggcc  ggcccgtga  240
cngcgcaca  aatgggccg  tgctgcttc  acacggcgg  gacgttgtc  ctgctcctg  300
tggtgacca  cgtcacgct  ctggtggcc  gggtcttcc  gaaggctgt  gaccagagt  360
tcgagaaga  aattgtgtt  aggaatggt  ctgaggcat  tgactcctg  gagaagccc  420
ctctgcctg  gtatactca  ttctatttc  tcaatgtca  caatccaga  gagatcctc  480
gaggggaga  ccctcgggt  gaagaagtg  ggccataca  ctacaggga  ctcagaaac  540
aagcaaata  tcaatttgg  gataatgga  caacaatat  tgctgttag  aacaaggcc  600
atgtttttg  acgagacca  tctgttgga  accctaaaa  tgacttaat  agaacatta  660
atattcctg  attgactgt  atagagtgg  cccaggtgc  cttcctcag  gagatcatc  720
aggccatgt  gaaagccta  cagcagaag  tctttgtga  tcacacagt  gacgaattg  780
tctggggct  caaagatga  atcttgtcc  ttatccatg  tttcaggcc  gatatctct  840
cctattttg  cctattcta  gagaaaaat  ggactaatg  tggagacta  gtttttcta  900
ctggagaag  cagttacct  aactttaca  aaattgtgg  atggaatgg  aaaacgtca  960
ttgactggt  gataacaga  aagtgcaat  tgattaatg  aacagatgg  gattctttt  1020
acccactaa  aaccaaaga  gaggtcctt  atgtcttcc  atctgactt  tgcaggtca  1080
tgtatatta  tttcagtga  tatgagagt  tacagggac  gcctgcctt  cggtataaa  1140
ttcctgcag  aatattagc  aatacgtca  acaatgccg  cttctgtat  cctgaggga  1200
actgcctgg  ctcaggagt  ctgaatgtc  gcatctgca  gaatggtgc  cccatcatt  1260
tgtctttcc  acactttta  caagcagat  agaggtttg  ttctgccat  gaaggcatg  1320
acccaaatc  ggaagacca  gagacattt  tggacatta  tcctttgac  ggaataatc  1380
taaaagcag  caagaggtt  caaatcaac  tttatgtca  aaaattaga  gactttgtt  1440
aaacgggag  cattagaac  atggttttc  cagtgatgt  cctcaatga  agtgttcac  1500
ttgataaag  gacggcgag  cgactgaag  ctatgatta  cactacttt  atcatcacc  1560
acataccct  catcatcat  gcgctgggt  tgttctttg  tttggtttt  acctggctt  1620
catgcaaag  acagggatc  atggatgag  gaacagcgg  tgaaagagc  cccctcatt  1680
gaacctaaa  attgccttt  cttggtgaa  aaactgtgt  agctgtcct  acctggacg  1740
tgacgtggg  aaaccctcc  cctccttgc  ggcttgttg  ctgttgaaa  aaggaaaaa  1800
acacggcgc  ggcaagtga  aggaacatt  tggccagag  ttaaagagc  ggctgacat  1860
gctggccat  aagctttat  aaatcatgt  ggctctgaa  ttgttcttt  atgtgtcta  1920
caagtattt  ataaaccct  gtatagtaa  tttgttgtt  ttgggtgct  gtagctcca  1980
aattttgtg  ccactattg  gggtaaaat  tctctgcat  acttgttaa  gctactggt  2040
taacttcat  cagtatgct  cattcaccg  actttgtgc  caaaatgcg  atataccat  2100
ttatgttgt  ttcctccat  tcacttgca  aacagaagt  aataagagt  cgggaccca  2160
ggtaaaatg  tagcttcat  caatatatc  ttcaaatgc  tctgatttc  aaaccatat  2220
acattttat  ctgatcttc  gttcataat  cttccagga  aactcagtc  tccaactgc  2280
ataaaatac  ggggtagga  tcaaatggg  aaggggggg  gggggggcc  2329



<210> 1582
<211> 477
<212> PRT
<213> Homo sapiens
<308> Q14108
<400> 1582

Gly Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu Leu 
  1               5                  10                  15
Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala Val 
             20                  25                  30
Asp Gln Ser Ile Glu Lys Lys Ile Val Leu Arg Asn Gly Thr Glu Ala 
         35                  40                  45
Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Thr Gln Phe Tyr 
     50                  55                  60
Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Arg Gly Glu Thr Pro 
 65                  70                  75                  80
Arg Val Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn Lys 
                 85                  90                  95
Ala Asn Ile Gln Phe Gly Asp Asn Gly Thr Thr Ile Ser Ala Val Ser 
             100                105                110
Asn Lys Ala Tyr Val Phe Glu Arg Asp Gln Ser Val Gly Asp Pro Lys 
         115                120                125
Ile Asp Leu Ile Arg Thr Leu Asn Ile Pro Val Leu Thr Val Ile Glu 
     130                135                140
Trp Ser Gln Val His Phe Leu Arg Glu Ile Ile Glu Ala Met Leu Lys 
 145                150                155                160
Ala Tyr Gln Gln Lys Leu Phe Val Thr His Thr Val Asp Glu Leu Leu 
                 165                170                175
Trp Gly Tyr Lys Asp Glu Ile Leu Ser Leu Ile His Val Phe Arg Pro 
             180                185                190
Asp Ile Ser Pro Tyr Phe Gly Leu Phe Tyr Glu Lys Asn Gly Thr Asn 
         195                200                205
Asp Gly Asp Tyr Val Phe Leu Thr Gly Glu Asp Ser Tyr Leu Asn Phe 
     210                215                220
Thr Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp Ile 
 225                230                235                240
Thr Asp Lys Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe His 
                 245                250                255
Pro Leu Ile Thr Lys Asp Glu Val Leu Tyr Val Phe Pro Ser Asp Phe 
             260                265                270
Cys Arg Ser Val Tyr Ile Thr Phe Ser Asp Tyr Glu Ser Val Gln Gly 
         275                280                285
Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn Thr 
     290                295                300
Ser Asp Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Leu Gly Ser 
 305                310                315                320
Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile Met 
                 325                330                335
Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Arg Phe Val Ser Ala Ile 
             340                345                350
Glu Gly Met His Pro Asn Gln Glu Asp His Glu Thr Phe Val Asp Ile 
         355                360                365
Asn Pro Leu Thr Gly Ile Ile Leu Lys Ala Ala Lys Arg Phe Gln Ile 
     370                375                380
Asn Ile Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly Asp Ile 
 385                390                395                400
Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val His Ile 
                 405                410                415
Asp Lys Glu Thr Ala Ser Arg Leu Lys Ser Met Ile Asn Thr Thr Leu 
             420                425                430
Ile Ile Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe Phe 
         435                440                445
Gly Leu Val Phe Thr Trp Leu Ala Cys Lys Gly Gln Gly Ser Met Asp 
     450                455                460
Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 
 465                470                475



<210> 1583
<211> 2064
<212> DNA
<213> Rattus norvegicus
<308> D10587
<400> 1583

cccagcacc  gcgatcgcg  gggctctgt  ctccgaggg  cgtgctcgc  tggtgccta  60
tccagggct  tgtacaccg  gcgggcggc  gctgagccc  caccaggag  gcgcgggag  120
cgcagggcc  tggagcttt  ggcgactgc  acgcggcct  ggccgaggc  cttccttgc  180
cgccgttct  tcgcgggcc  ggcccgtga  ccgctcaca  tatggcccg  tgctgcttc  240
acacggcgg  gacactgtc  ctgctgctg  tggtgacca  tgtcacgct  ctagtggct  300
gagtctttc  gaaggcagt  gaccagacg  tcgagaaga  tatggtatt  caaaatggt  360
ccaaggtct  tgattcctg  gagaagccc  ctctacctg  gtacatcca  ttttatttc  420
tcaatgtca  caatccaga  gagatcctc  aaggagaaa  ccccctgct  gaagaagtg  480
ggccgtaca  ctacaggga  ctcaggaac  aggcaaacg  tcagtttgg  gaaaatgga  540
caaccatat  tgccgtcac  aataaggca  atatttttg  acgaaacca  tctgttgga  600
accctaccg  tgacttgat  agaacaata  atattcctc  gttgactgt  gtggaaatg  660
cccagcagc  cttcctcag  gagatcatc  aggccatgc  gaaagctta  cagcagacg  720
tgtttgtca  tcacactgt  catgaactg  tctggggct  caaagatga  gtcttgtcg  780
tcgtccata  tttcagacc  gacgtctcc  ctaactttg  cctgttcta  gagagaaat  840
gaactaatg  tggggagta  gtttttctg  ctggagagg  caattacct  aactttaca  900
aaattgtgg  gtggaatgg  aaaacgtcg  tggactggt  gacgacgga  acgtgcaat  960
tgatcaacg  gacagacgg  gattctttt  acccattaa  aagcaagga  gagaccctg  1020
acatcttcc  atctgactt  tgcaggtcc  tctatataa  tttcagtag  tttgagaac  1080
tagaaggac  gcctgcttt  cggtataag  tgcctgcag  aatactagc  aattcctcc  1140
aaaacgctg  cttctgtat  cccgaggga  actgcatgg  cgcgggagt  ctgaacgtc  1200
gcatttgca  gaatggtgc  cccattatc  tgtctttcc  acactttta  caagccgac  1260
agaagttcg  ttcggccat  aaaggcatg  gtccaaaca  ggaagaaca  gagtcattt  1320
tggacatta  tcctttgac  ggaattatt  taagagggg  caagagatt  caaatcaac  1380
cgtacgtta  gaagctgga  gactttgtg  aaacgggaa  cattaggac  atggttttc  1440
cagtgatgt  tctcaatga  agtgttctc  ttgacaaag  gactgcaag  caactgaag  1500
ctgtgatta  cacaacttt  attgtcacc  acataccct  catcatcat  gcactgggc  1560
tgttctttg  cttgatttt  acgtggctg  cgtgtcgag  acaggggtc  acggatgag  1620
gaactgcag  tgaaagggc  cccctcata  ggacctaat  ggacttacc  gttgcctga  1680
cttggtgag  gaatgtgag  actgacctg  cctggacca  gacagggaa  agcctgcat  1740
ctcacgggc  cctggcctg  caagaaggg  gtgaagccg  agcactggc  cgcgagaag  1800
ccctcctgg  cagagggga  cgagcaggt  acatggctg  caattacgc  ttataaaat  1860
atgtctctg  aactgtgtc  atgtgtctt  gggagtatt  aataaattg  gtagaaacc  1920
tttgtgatt  ggctctggg  gctgtgggg  tttgtaacc  ctgttgtag  tacagtgtc  1980
gagtcactt  ttaatgtta  cttggcctg  cccgattca  tatgcctca  tctccaaac  2040
ttgtgttta  aatatgaaa  aaaa  2064



<210> 1584
<211> 477
<212> PRT
<213> Rattus norvegicus
<308> BAA01444
<400> 1584

Ala Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu Leu 
  1               5                  10                  15
Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala Val 
             20                  25                  30
Asp Gln Thr Ile Glu Lys Asn Met Val Leu Gln Asn Gly Thr Lys Val 
         35                  40                  45
Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Ile Gln Phe Tyr 
     50                  55                  60
Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Gln Gly Glu Ile Pro 
 65                  70                  75                  80
Leu Leu Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn Lys 
                 85                  90                  95
Ala Asn Val Gln Phe Gly Glu Asn Gly Thr Thr Ile Ser Ala Val Thr 
             100                105                110
Asn Lys Ala Tyr Ile Phe Glu Arg Asn Gln Ser Val Gly Asp Pro Thr 
         115                120                125
Val Asp Leu Ile Arg Thr Ile Asn Ile Pro Leu Leu Thr Val Val Glu 
     130                135                140
Met Ala Gln Gln Pro Phe Leu Arg Glu Ile Ile Glu Ala Met Leu Lys 
 145                150                155                160
Ala Tyr Gln Gln Thr Leu Phe Val Thr His Thr Val His Glu Leu Leu 
                 165                170                175
Trp Gly Tyr Lys Asp Glu Val Leu Ser Leu Val His Ile Phe Arg Pro 
             180                185                190
Asp Val Ser Pro Asn Phe Gly Leu Phe Tyr Glu Arg Asn Gly Thr Asn 
         195                200                205
Asp Gly Glu Tyr Val Phe Leu Thr Gly Glu Asp Asn Tyr Leu Asn Phe 
     210                215                220
Thr Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp Thr 
 225                230                235                240
Thr Asp Thr Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe His 
                 245                250                255
Pro Leu Ile Ser Lys Asp Glu Thr Leu Tyr Ile Phe Pro Ser Asp Phe 
             260                265                270
Cys Arg Ser Val Tyr Ile Thr Phe Ser Ser Phe Glu Asn Val Glu Gly 
         275                280                285
Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn Ser 
     290                295                300
Ser Glu Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Met Asp Ala 
 305                310                315                320
Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile Met 
                 325                330                335
Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Lys Phe Val Ser Ala Ile 
             340                345                350
Lys Gly Met Arg Pro Asn Lys Glu Glu His Glu Ser Phe Val Asp Ile 
         355                360                365
Asn Pro Leu Thr Gly Ile Ile Leu Arg Gly Ala Lys Arg Phe Gln Ile 
     370                375                380
Asn Thr Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly Asn Ile 
 385                390                395                400
Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val Leu Ile 
                 405                410                415
Asp Lys Glu Thr Ala Ser Gln Leu Lys Ser Val Ile Asn Thr Thr Leu 
             420                425                430
Ile Val Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe Phe 
         435                440                445
Gly Leu Ile Phe Thr Trp Leu Ala Cys Arg Gly Gln Gly Ser Thr Asp 
     450                455                460
Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 
 465                470                475



<210> 1585
<211> 2329
<212> DNA
<213> Homo sapiens
<308> D12676
<400> 1585

cacggctgc  cggcgaagg  aaccgaaac  gagtccggg  ccgtccctc  gcggcccca  60
ccgcccggt  cacccgggg  cgcgctcgc  aggccgcgg  gccagagct  cgcgcacga  120
ccgtgcgcg  gagggcgtg  gcgttgcgc  gaagggtcc  gagtcttcg  cgcctctgc  180
gcggctcct  cctccttgc  gttggatcc  tggcgggtg  ggcccggcc  ggcccgtga  240
cngcgcaca  aatgggccg  tgctgcttc  acacggcgg  gacgttgtc  ctgctcctg  300
tggtgacca  cgtcacgct  ctggtggcc  gggtcttcc  gaaggctgt  gaccagagt  360
tcgagaaga  aattgtgtt  aggaatggt  ctgaggcat  tgactcctg  gagaagccc  420
ctctgcctg  gtatactca  ttctatttc  tcaatgtca  caatccaga  gagatcctc  480
gaggggaga  ccctcgggt  gaagaagtg  ggccataca  ctacaggga  ctcagaaac  540
aagcaaata  tcaatttgg  gataatgga  caacaatat  tgctgttag  aacaaggcc  600
atgtttttg  acgagacca  tctgttgga  accctaaaa  tgacttaat  agaacatta  660
atattcctg  attgactgt  atagagtgg  cccaggtgc  cttcctcag  gagatcatc  720
aggccatgt  gaaagccta  cagcagaag  tctttgtga  tcacacagt  gacgaattg  780
tctggggct  caaagatga  atcttgtcc  ttatccatg  tttcaggcc  gatatctct  840
cctattttg  cctattcta  gagaaaaat  ggactaatg  tggagacta  gtttttcta  900
ctggagaag  cagttacct  aactttaca  aaattgtgg  atggaatgg  aaaacgtca  960
ttgactggt  gataacaga  aagtgcaat  tgattaatg  aacagatgg  gattctttt  1020
acccactaa  aaccaaaga  gaggtcctt  atgtcttcc  atctgactt  tgcaggtca  1080
tgtatatta  tttcagtga  tatgagagt  tacagggac  gcctgcctt  cggtataaa  1140
ttcctgcag  aatattagc  aatacgtca  acaatgccg  cttctgtat  cctgaggga  1200
actgcctgg  ctcaggagt  ctgaatgtc  gcatctgca  gaatggtgc  cccatcatt  1260
tgtctttcc  acactttta  caagcagat  agaggtttg  ttctgccat  gaaggcatg  1320
acccaaatc  ggaagacca  gagacattt  tggacatta  tcctttgac  ggaataatc  1380
taaaagcag  caagaggtt  caaatcaac  tttatgtca  aaaattaga  gactttgtt  1440
aaacgggag  cattagaac  atggttttc  cagtgatgt  cctcaatga  agtgttcac  1500
ttgataaag  gacggcgag  cgactgaag  ctatgatta  cactacttt  atcatcacc  1560
acataccct  catcatcat  gcgctgggt  tgttctttg  tttggtttt  acctggctt  1620
catgcaaag  acagggatc  atggatgag  gaacagcgg  tgaaagagc  cccctcatt  1680
gaacctaaa  attgccttt  cttggtgaa  aaactgtgt  agctgtcct  acctggacg  1740
tgacgtggg  aaaccctcc  cctccttgc  ggcttgttg  ctgttgaaa  aaggaaaaa  1800
acacggcgc  ggcaagtga  aggaacatt  tggccagag  ttaaagagc  ggctgacat  1860
gctggccat  aagctttat  aaatcatgt  ggctctgaa  ttgttcttt  atgtgtcta  1920
caagtattt  ataaaccct  gtatagtaa  tttgttgtt  ttgggtgct  gtagctcca  1980
aattttgtg  ccactattg  gggtaaaat  tctctgcat  acttgttaa  gctactggt  2040
taacttcat  cagtatgct  cattcaccg  actttgtgc  caaaatgcg  atataccat  2100
ttatgttgt  ttcctccat  tcacttgca  aacagaagt  aataagagt  cgggaccca  2160
ggtaaaatg  tagcttcat  caatatatc  ttcaaatgc  tctgatttc  aaaccatat  2220
acattttat  ctgatcttc  gttcataat  cttccagga  aactcagtc  tccaactgc  2280
ataaaatac  ggggtagga  tcaaatggg  aaggggggg  gggggggcc  2329



<210> 1586
<211> 477
<212> PRT
<213> Homo sapiens
<308> Q14108
<400> 1586

Gly Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu Leu 
  1               5                  10                  15
Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala Val 
             20                  25                  30
Asp Gln Ser Ile Glu Lys Lys Ile Val Leu Arg Asn Gly Thr Glu Ala 
         35                  40                  45
Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Thr Gln Phe Tyr 
     50                  55                  60
Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Arg Gly Glu Thr Pro 
 65                  70                  75                  80
Arg Val Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn Lys 
                 85                  90                  95
Ala Asn Ile Gln Phe Gly Asp Asn Gly Thr Thr Ile Ser Ala Val Ser 
             100                105                110
Asn Lys Ala Tyr Val Phe Glu Arg Asp Gln Ser Val Gly Asp Pro Lys 
         115                120                125
Ile Asp Leu Ile Arg Thr Leu Asn Ile Pro Val Leu Thr Val Ile Glu 
     130                135                140
Trp Ser Gln Val His Phe Leu Arg Glu Ile Ile Glu Ala Met Leu Lys 
 145                150                155                160
Ala Tyr Gln Gln Lys Leu Phe Val Thr His Thr Val Asp Glu Leu Leu 
                 165                170                175
Trp Gly Tyr Lys Asp Glu Ile Leu Ser Leu Ile His Val Phe Arg Pro 
             180                185                190
Asp Ile Ser Pro Tyr Phe Gly Leu Phe Tyr Glu Lys Asn Gly Thr Asn 
         195                200                205
Asp Gly Asp Tyr Val Phe Leu Thr Gly Glu Asp Ser Tyr Leu Asn Phe 
     210                215                220
Thr Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp Ile 
 225                230                235                240
Thr Asp Lys Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe His 
                 245                250                255
Pro Leu Ile Thr Lys Asp Glu Val Leu Tyr Val Phe Pro Ser Asp Phe 
             260                265                270
Cys Arg Ser Val Tyr Ile Thr Phe Ser Asp Tyr Glu Ser Val Gln Gly 
         275                280                285
Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn Thr 
     290                295                300
Ser Asp Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Leu Gly Ser 
 305                310                315                320
Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile Met 
                 325                330                335
Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Arg Phe Val Ser Ala Ile 
             340                345                350
Glu Gly Met His Pro Asn Gln Glu Asp His Glu Thr Phe Val Asp Ile 
         355                360                365
Asn Pro Leu Thr Gly Ile Ile Leu Lys Ala Ala Lys Arg Phe Gln Ile 
     370                375                380
Asn Ile Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly Asp Ile 
 385                390                395                400
Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val His Ile 
                 405                410                415
Asp Lys Glu Thr Ala Ser Arg Leu Lys Ser Met Ile Asn Thr Thr Leu 
             420                425                430
Ile Ile Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe Phe 
         435                440                445
Gly Leu Val Phe Thr Trp Leu Ala Cys Lys Gly Gln Gly Ser Met Asp 
     450                455                460
Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 
 465                470                475



<210> 1587
<211> 2266
<212> DNA
<213> Rattus norvegicus
<308> D10655
<400> 1587

cctacaatg  aggcaggca  catagcccg  tgggaaaaa  aagaagggg  aaaaatcag  60
gagggtgat  taattgcag  ggttgaaac  gataaagcc  ctgttggat  tgagagctt  120
gaggagtgc  atatggcaa  gatccttgt  cctgagggg  ccagagatg  tccgatagg  180
tgtatcatt  gtatcacag  tgaaaagcc  caggatatt  aggccttta  aaattatac  240
ttggattca  caacagctg  cacacaggc  gccccagcc  cagctgcag  tccagctgc  300
gccccagct  caccttctg  aagtgctcc  ggtagctcc  atcccgttc  catgcagat  360
gttcttcct  ccctctccc  aaccatgac  atgggcacc  tccagaggt  ggaaaagaa  420
gtgggagag  agctgagtg  aggagactt  ctggcagag  tagagaccg  caaggccac  480
ataggcttt  aagtacaag  agaaggtta  ctggcaaaa  tcctggtcc  tgaaggcac  540
agggatgtt  ctctgggaa  cccgctatg  atcatagta  aaaaacagg  agatatagc  600
gcatttgca  actacaggc  aacagaagt  accagctta  agccacagg  accaccacc  660
gtcccaccc  cagtggcag  tgttcctcc  atcccccag  ctttagcac  taccccctc  720
gccgctcct  ctggaccaa  gggaagggt  ttcgttagc  ctcttgcaa  gaaattggc  780
gcagagaaa  ggattgacc  cacccaagt  aaagggacg  gaccagaag  cagaatcat  840
aagaaggac  ttgactctt  tgtgcctac  aaggctgct  ctgccgctg  agcagctgc  900
cccccgggt  caagagtgg  accaactcc  gcaggtgtc  tcatagaca  ccccatcag  960
aacattcgt  gagtgattg  gcagaggct  atgcagtcg  agcagacta  acctcatta  1020
tacctttct  ttgatgtaa  tatgggaga  gtgctgttg  tgcggaagg  acttaataa  1080
atgcttgaa  gtaaaggaa  aatctccgt  aatgacttc  tcataaaag  ttcagcttt  1140
gcctgcctg  aagttcctg  agcaaactc  tcttggatg  acacagtta  acgacaaaa  1200
catgtggtt  atgtcagcg  tgctgtcag  acccctgca  gacttatca  ccctattgt  1260
tttaatgca  acataaaag  actggaaac  attgctagt  atgttgttt  tttagcctc  1320
aaagcaaga  agggtaaac  tcagcctca  gagttccag  gtgggacat  tacaatctc  1380
aacttaggg  tgttcggaa  taagaattt  tctgcgatt  ttaacccac  tcaggcatg  1440
attttggca  ttggtgctt  cgaggataa  ctgatccct  cagataatg  gaaaggctt  1500
gacgtggct  gtgtgatgt  tgtcacact  agctgtgat  atcgagttg  ggatggagc  1560
gttggagcc  agtggcttg  tgaattcaa  aagtacctt  aaaagcctg  aactatgtt  1620
ttataattt  cctgcgaac  tctattctt  ctctgctga  attatattt  tatgttatt  1680
aacaggtgg  tcttttaaa  tttcactag  taattttat  attgagtca  tccagataa  1740
ttatttgta  cagacataa  tgaatcttt  gtaaatgcc  gttacaccc  aatgtttta  1800
ccctttaat  attacacat  ggtttaaag  tgtgtactc  tagtgaagg  gacatgtgg  1860
cctaactct  tggtagaag  agccttcct  ggagtgata  atggcagga  tgtggcttc  1920
tgcagacaa  tcactaaaa  tacctggat  agatacttg  agttagatt  atgatcact  1980
atttaagtg  gagggaaca  tcgtgaaaa  tacgtctta  ggaggagtt  gaatttacg  2040
tggaatcta  cagttaaag  ctcctgtca  atgacctta  tttatcact  agtaagtga  2100
acttttaag  gtcagcatt  tcttagacc  cttcaaacc  actattatt  ttatatgaa  2160
ctctaaata  aatagcttt  cccacaaga  aaagatata  accagcttc  tggtataaa  2220
gaaatttta  gtatttatt  ataaacaat  tcaatgtat  acttga  2266



<210> 1588
<211> 555
<212> PRT
<213> Rattus norvegicus
<308> P08461
<400> 1588

Ser Leu Pro Pro His Gln Lys Val Pro Leu Pro Ser Leu Ser Pro Thr 
  1               5                  10                  15
Met Gln Ala Gly Thr Ile Ala Arg Trp Glu Lys Lys Glu Gly Glu Lys 
             20                  25                  30
Ile Ser Glu Gly Asp Leu Ile Ala Glu Val Glu Thr Asp Lys Ala Thr 
         35                  40                  45
Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr Met Ala Lys Ile Leu Val 
     50                  55                  60
Pro Glu Gly Thr Arg Asp Val Pro Ile Gly Cys Ile Ile Cys Ile Thr 
 65                  70                  75                  80
Val Glu Lys Pro Gln Asp Ile Glu Ala Phe Lys Asn Tyr Thr Leu Asp 
                 85                  90                  95
Ser Ala Thr Ala Ala Thr Gln Ala Ala Pro Ala Pro Ala Ala Ala Pro 
             100                105                110
Ala Ala Ala Pro Ala Ala Pro Ser Ala Ser Ala Pro Gly Ser Ser Tyr 
         115                120                125
Pro Val His Met Gln Ile Val Leu Pro Ala Leu Ser Pro Thr Met Thr 
     130                135                140
Met Gly Thr Val Gln Arg Trp Glu Lys Lys Val Gly Glu Lys Leu Ser 
 145                150                155                160
Glu Gly Asp Leu Leu Ala Glu Ile Glu Thr Asp Lys Ala Thr Ile Gly 
                 165                170                175
Phe Glu Val Gln Glu Glu Gly Tyr Leu Ala Lys Ile Leu Val Pro Glu 
             180                185                190
Gly Thr Arg Asp Val Pro Leu Gly Thr Pro Leu Cys Ile Ile Val Glu 
         195                200                205
Lys Gln Glu Asp Ile Ala Ala Phe Ala Asp Tyr Arg Pro Thr Glu Val 
     210                215                220
Thr Ser Leu Lys Pro Gln Ala Pro Pro Pro Val Pro Pro Pro Val Ala 
 225                230                235                240
Ala Val Pro Pro Ile Pro Gln Pro Leu Ala Pro Thr Pro Ser Ala Ala 
                 245                250                255
Pro Ala Gly Pro Lys Gly Arg Val Phe Val Ser Pro Leu Ala Lys Lys 
             260                265                270
Leu Ala Ala Glu Lys Gly Ile Asp Leu Thr Gln Val Lys Gly Thr Gly 
         275                280                285
Pro Glu Gly Arg Ile Ile Lys Lys Asp Ile Asp Ser Phe Val Pro Thr 
     290                295                300
Lys Ala Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro Gly Pro Arg Val 
 305                310                315                320
Ala Pro Thr Pro Ala Gly Val Phe Ile Asp Ile Pro Ile Ser Asn Ile 
                 325                330                335
Arg Arg Val Ile Ala Gln Arg Leu Met Gln Ser Lys Gln Thr Ile Pro 
             340                345                350
His Tyr Tyr Leu Ser Val Asp Val Asn Met Gly Glu Val Leu Leu Val 
         355                360                365
Arg Lys Glu Leu Asn Lys Met Leu Glu Gly Lys Gly Lys Ile Ser Val 
     370                375                380
Asn Asp Phe Ile Ile Lys Ala Ser Ala Leu Ala Cys Leu Lys Val Pro 
 385                390                395                400
Glu Ala Asn Ser Ser Trp Met Asp Thr Val Ile Arg Gln Asn His Val 
                 405                410                415
Val Asp Val Ser Val Ala Val Ser Thr Pro Ala Gly Leu Ile Thr Pro 
             420                425                430
Ile Val Phe Asn Ala His Ile Lys Gly Leu Glu Thr Ile Ala Ser Asp 
         435                440                445
Val Val Ser Leu Ala Ser Lys Ala Arg Glu Gly Lys Leu Gln Pro His 
     450                455                460
Glu Phe Gln Gly Gly Thr Phe Thr Ile Ser Asn Leu Gly Met Phe Gly 
 465                470                475                480
Ile Lys Asn Phe Ser Ala Ile Ile Asn Pro Pro Gln Ala Cys Ile Leu 
                 485                490                495
Ala Ile Gly Ala Ser Glu Asp Lys Leu Ile Pro Ala Asp Asn Glu Lys 
             500                505                510
Gly Phe Asp Val Ala Ser Val Met Ser Val Thr Leu Ser Cys Asp His 
         515                520                525
Arg Val Val Asp Gly Ala Val Gly Ala Gln Trp Leu Ala Glu Phe Lys 
     530                535                540
Lys Tyr Leu Glu Lys Pro Val Thr Met Leu Leu 
 545                550                555



<210> 1589
<211> 2583
<212> DNA
<213> Homo sapiens
<308> Y00978
<400> 1589

cgagtgacc  cgcgatctg  cccggctcc  gctcgtcgc  acagcgtga  tacagggta  60
ggcggggtc  gggcactgt  cggctggac  cccagttct  gggccacgc  gcggaaccg  120
ttactgctg  agcttttgg  gtcgcccgg  cgccgctat  acagtcttc  cccgcatca  180
aaggttcca  tgccttctc  ttcccccac  atgcaggca  gcaccatag  ccgttggaa  240
aaaaaagag  gggacaaaa  caatgaagg  gacctaatt  cagaggttg  aactgataa  300
gccactgtt  gatttgaga  cctggagga  tgttatatg  caaagatac  tgttgctga  360
ggtaccagg  atgttccca  cggagcgat  atctgtatc  cagttggca  gcctgagga  420
attgaggcc  ttaaaaatt  tacactgga  tcctcagca  cacctaccc  acaagcggc  480
ccagcacca  cccctgctg  cactgcttc  ccacctaca  cttctgctc  ggctcctgg  540
agctcatat  cccctcaca  gcaggtact  cttcctgcc  tctctccca  catgaccat  600
ggcacagtt  agagatggg  aaaaaaagt  ggtgagaag  taagtgaag  agacttact  660
gcagagata  aaactgaca  agccactat  ggttttgaa  tacaggaag  aggttatct  720
gcaaaaatc  tggtccctg  aggcacaag  gatgtccct  taggaaccc  actctgtat  780
attgtagaa  aagaggcag  tatatcagc  tttgctgac  ataggccaa  cgaagtaac  840
gatttaaaa  cacaagtgc  accacctac  ccacccccg  tggccgctg  tcctccaac  900
ccccagcct  tagctccta  accttcagc  ccctgccca  ctactcctg  tggaccaaa  960
ggaagggtg  ttgttagcc  tcttgcaaa  aagttggca  tagagaaag  gattgatct  1020
acacaagta  aagggacag  accagatgg  agaatcacc  agaaggata  cgactcttt  1080
gtgcctagt  aagttgctc  tgctccggc  gctgttgtg  ctcccacag  tcctggaat  1140
gcaccagtt  ctacaggtg  cttcacaga  atcccaatc  gcaacattc  tcgggttat  1200
gcacagcga  taatgcaat  aaagcaaac  atacctcat  attaccttt  tatcgatgt  1260
aatatggga  aagttttgt  ggtacggaa  gaacttaat  agatattag  agggagaag  1320
aaaatttct  tcaatgact  catcataaa  gcttcagct  tggcatgtt  aaaagttcc  1380
gaagcaaat  cttcttgga  ggacacagt  ataagacaa  atcatgttg  tgatgtcag  1440
gttgcggtc  gtactcctg  aggactcat  acacctatt  tgtttaatg  acatataaa  1500
ggagtggaa  ccattgcta  tgatgttgt  tctttagca  ccaaagcaa  agagggtaa  1560
ctacagcca  atgaattcc  gggtggcac  tttacgatc  ccaatttag  aatgtttgg  1620
attaagaat  tctctgcta  tattaaccc  cctcaagca  gtattttgg  aattggtgc  1680
tcagaggat  aactggtcc  tgcagataa  gaaaaaggg  ttgatgtgg  tagcatgat  1740
tctgttaca  tcagttgtg  tcaccgggt  gtggatgga  cagttggag  ccagtggct  1800
gctgagttt  gaaagtacc  tgaaaaacc  atcactatg  tgttgtaac  aactcaaga  1860
tttctaaac  ctcccaggt  acactgatt  attcttaac  agatattta  atgttatta  1920
acaggtggt  gctttttat  ttaaccagt  atttttatt  ttgagtctg  tcagataag  1980
tatttataa  gggcattac  gaattttta  aatgccgat  acacccaaa  attgtgcac  2040
tttaataat  agacaccag  tttttagct  tgtactcct  attaaggga  atgtatgtg  2100
ccttgccta  ccctttggt  ataagtact  cctctagga  atgtacgat  ggtagaatt  2160
tggttccct  aagacaagt  cataaaggt  accctgatg  aaccttgaa  ttctgaaat  2220
taactgcct  aaatgttct  cttagatgt  agagaaaga  aaatcagaa  aattaattc  2280
cttggggga  gggcttgaa  tgaagcttt  ctttagaat  tagccctgg  ttgaaattt  2340
ccattacat  atcttggtt  atcatcgat  ggaagggta  aaaacttca  ggaaaataa  2400
tgaaatttt  aaagtcagc  ttttcttag  cctcttcag  tgattgttt  tttttctat  2460
aattctgta  tcaaaatta  acatttgtt  aaataaata  ccacacaaa  tctcagtta  2520
atcaagtag  tggtttata  ttagattat  tcaagtagg  gggaataac  atgtgtagg  2580
att  2583



<210> 1590
<211> 614
<212> PRT
<213> Homo sapiens
<308> P10515
<400> 1590

Met Ser Pro His Cys Ser Thr Thr Tyr Leu Arg Thr Leu Gly Arg Thr 
  1               5                  10                  15
Thr Met Phe Trp Lys Thr Thr Glu Gly Arg Asp Gly Lys Met Ala Val 
             20                  25                  30
Gln Glu Phe Ser Glu Phe Gly Leu Leu Leu Gln Leu Leu Gly Ser Pro 
         35                  40                  45
Gly Arg Arg Tyr Tyr Ser Leu Pro Pro His Gln Lys Val Pro Leu Pro 
     50                  55                  60
Ser Leu Ser Pro Thr Met Gln Ala Gly Thr Ile Ala Arg Trp Glu Lys 
 65                  70                  75                  80
Lys Glu Gly Asp Lys Ile Asn Glu Gly Asp Leu Ile Ala Glu Val Glu 
                 85                  90                  95
Thr Asp Lys Ala Thr Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr Met 
             100                105                110
Ala Lys Ile Leu Val Ala Glu Gly Thr Arg Asp Val Pro Ile Gly Ala 
         115                120                125
Ile Ile Cys Ile Thr Val Gly Lys Pro Glu Asp Ile Glu Ala Phe Lys 
     130                135                140
Asn Tyr Thr Leu Asp Ser Ser Ala Ala Pro Thr Pro Gln Ala Ala Pro 
 145                150                155                160
Ala Pro Thr Pro Ala Ala Thr Ala Ser Pro Pro Thr Pro Ser Ala Gln 
                 165                170                175
Ala Pro Gly Ser Ser Tyr Pro Pro His Met Gln Val Leu Leu Pro Ala 
             180                185                190
Leu Ser Pro Thr Met Thr Met Gly Thr Val Gln Arg Trp Glu Lys Lys 
         195                200                205
Val Gly Glu Lys Leu Ser Glu Gly Asp Leu Leu Ala Glu Ile Glu Thr 
     210                215                220
Asp Lys Ala Thr Ile Gly Phe Glu Val Gln Glu Glu Gly Tyr Leu Ala 
 225                230                235                240
Lys Ile Leu Val Pro Glu Gly Thr Arg Asp Val Pro Leu Gly Thr Pro 
                 245                250                255
Leu Cys Ile Ile Val Glu Lys Glu Ala Asp Ile Ser Ala Phe Ala Asp 
             260                265                270
Tyr Arg Pro Thr Glu Val Thr Asp Leu Lys Pro Gln Val Pro Pro Pro 
         275                280                285
Thr Pro Pro Pro Val Ala Ala Val Pro Pro Thr Pro Gln Pro Leu Ala 
     290                295                300
Pro Thr Pro Ser Thr Pro Cys Pro Ala Thr Pro Ala Gly Pro Lys Gly 
 305                310                315                320
Arg Val Phe Val Asp Pro Leu Ala Lys Lys Leu Ala Val Glu Lys Gly 
                 325                330                335
Ile Asp Leu Thr Gln Val Lys Gly Thr Gly Pro Asp Gly Arg Ile Thr 
             340                345                350
Lys Lys Asp Ile Asp Ser Phe Val Pro Ser Lys Val Ala Pro Ala Pro 
         355                360                365
Ala Ala Val Val Pro Pro Thr Gly Pro Gly Met Ala Pro Val Pro Thr 
     370                375                380
Gly Val Phe Thr Asp Ile Pro Ile Ser Asn Ile Arg Arg Val Ile Ala 
 385                390                395                400
Gln Arg Leu Met Gln Ser Lys Gln Thr Ile Pro His Tyr Tyr Leu Ser 
                 405                410                415
Ile Asp Val Asn Met Gly Glu Val Leu Leu Val Arg Lys Glu Leu Asn 
             420                425                430
Lys Ile Leu Glu Gly Arg Ser Lys Ile Ser Val Asn Asp Phe Ile Ile 
         435                440                445
Lys Ala Ser Ala Leu Ala Cys Leu Lys Val Pro Glu Ala Asn Ser Ser 
     450                455                460
Trp Met Asp Thr Val Ile Arg Gln Asn His Val Val Asp Val Ser Val 
 465                470                475                480
Ala Val Ser Thr Pro Ala Gly Leu Ile Thr Pro Ile Val Phe Asn Ala 
                 485                490                495
His Ile Lys Gly Val Glu Thr Ile Ala Asn Asp Val Val Ser Leu Ala 
             500                505                510
Thr Lys Ala Arg Glu Gly Lys Leu Gln Pro His Glu Phe Gln Gly Gly 
         515                520                525
Thr Phe Thr Ile Ser Asn Leu Gly Met Phe Gly Ile Lys Asn Phe Ser 
     530                535                540
Ala Ile Ile Asn Pro Pro Gln Ala Cys Ile Leu Ala Ile Gly Ala Ser 
 545                550                555                560
Glu Asp Lys Leu Val Pro Ala Asp Asn Glu Lys Gly Phe Asp Val Ala 
                 565                570                575
Ser Met Met Ser Val Thr Leu Ser Cys Asp His Arg Val Val Asp Gly 
             580                585                590
Ala Val Gly Ala Gln Trp Leu Ala Glu Phe Arg Lys Tyr Leu Glu Lys 
         595                600                605
Pro Ile Thr Met Leu Leu 
     610



<210> 1591
<211> 2266
<212> DNA
<213> Rattus norvegicus
<308> D10655
<400> 1591

cctacaatg  aggcaggca  catagcccg  tgggaaaaa  aagaagggg  aaaaatcag  60
gagggtgat  taattgcag  ggttgaaac  gataaagcc  ctgttggat  tgagagctt  120
gaggagtgc  atatggcaa  gatccttgt  cctgagggg  ccagagatg  tccgatagg  180
tgtatcatt  gtatcacag  tgaaaagcc  caggatatt  aggccttta  aaattatac  240
ttggattca  caacagctg  cacacaggc  gccccagcc  cagctgcag  tccagctgc  300
gccccagct  caccttctg  aagtgctcc  ggtagctcc  atcccgttc  catgcagat  360
gttcttcct  ccctctccc  aaccatgac  atgggcacc  tccagaggt  ggaaaagaa  420
gtgggagag  agctgagtg  aggagactt  ctggcagag  tagagaccg  caaggccac  480
ataggcttt  aagtacaag  agaaggtta  ctggcaaaa  tcctggtcc  tgaaggcac  540
agggatgtt  ctctgggaa  cccgctatg  atcatagta  aaaaacagg  agatatagc  600
gcatttgca  actacaggc  aacagaagt  accagctta  agccacagg  accaccacc  660
gtcccaccc  cagtggcag  tgttcctcc  atcccccag  ctttagcac  taccccctc  720
gccgctcct  ctggaccaa  gggaagggt  ttcgttagc  ctcttgcaa  gaaattggc  780
gcagagaaa  ggattgacc  cacccaagt  aaagggacg  gaccagaag  cagaatcat  840
aagaaggac  ttgactctt  tgtgcctac  aaggctgct  ctgccgctg  agcagctgc  900
cccccgggt  caagagtgg  accaactcc  gcaggtgtc  tcatagaca  ccccatcag  960
aacattcgt  gagtgattg  gcagaggct  atgcagtcg  agcagacta  acctcatta  1020
tacctttct  ttgatgtaa  tatgggaga  gtgctgttg  tgcggaagg  acttaataa  1080
atgcttgaa  gtaaaggaa  aatctccgt  aatgacttc  tcataaaag  ttcagcttt  1140
gcctgcctg  aagttcctg  agcaaactc  tcttggatg  acacagtta  acgacaaaa  1200
catgtggtt  atgtcagcg  tgctgtcag  acccctgca  gacttatca  ccctattgt  1260
tttaatgca  acataaaag  actggaaac  attgctagt  atgttgttt  tttagcctc  1320
aaagcaaga  agggtaaac  tcagcctca  gagttccag  gtgggacat  tacaatctc  1380
aacttaggg  tgttcggaa  taagaattt  tctgcgatt  ttaacccac  tcaggcatg  1440
attttggca  ttggtgctt  cgaggataa  ctgatccct  cagataatg  gaaaggctt  1500
gacgtggct  gtgtgatgt  tgtcacact  agctgtgat  atcgagttg  ggatggagc  1560
gttggagcc  agtggcttg  tgaattcaa  aagtacctt  aaaagcctg  aactatgtt  1620
ttataattt  cctgcgaac  tctattctt  ctctgctga  attatattt  tatgttatt  1680
aacaggtgg  tcttttaaa  tttcactag  taattttat  attgagtca  tccagataa  1740
ttatttgta  cagacataa  tgaatcttt  gtaaatgcc  gttacaccc  aatgtttta  1800
ccctttaat  attacacat  ggtttaaag  tgtgtactc  tagtgaagg  gacatgtgg  1860
cctaactct  tggtagaag  agccttcct  ggagtgata  atggcagga  tgtggcttc  1920
tgcagacaa  tcactaaaa  tacctggat  agatacttg  agttagatt  atgatcact  1980
atttaagtg  gagggaaca  tcgtgaaaa  tacgtctta  ggaggagtt  gaatttacg  2040
tggaatcta  cagttaaag  ctcctgtca  atgacctta  tttatcact  agtaagtga  2100
acttttaag  gtcagcatt  tcttagacc  cttcaaacc  actattatt  ttatatgaa  2160
ctctaaata  aatagcttt  cccacaaga  aaagatata  accagcttc  tggtataaa  2220
gaaatttta  gtatttatt  ataaacaat  tcaatgtat  acttga  2266



<210> 1592
<211> 555
<212> PRT
<213> Rattus norvegicus
<308> P08461
<400> 1592

Ser Leu Pro Pro His Gln Lys Val Pro Leu Pro Ser Leu Ser Pro Thr 
  1               5                  10                  15
Met Gln Ala Gly Thr Ile Ala Arg Trp Glu Lys Lys Glu Gly Glu Lys 
             20                  25                  30
Ile Ser Glu Gly Asp Leu Ile Ala Glu Val Glu Thr Asp Lys Ala Thr 
         35                  40                  45
Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr Met Ala Lys Ile Leu Val 
     50                  55                  60
Pro Glu Gly Thr Arg Asp Val Pro Ile Gly Cys Ile Ile Cys Ile Thr 
 65                  70                  75                  80
Val Glu Lys Pro Gln Asp Ile Glu Ala Phe Lys Asn Tyr Thr Leu Asp 
                 85                  90                  95
Ser Ala Thr Ala Ala Thr Gln Ala Ala Pro Ala Pro Ala Ala Ala Pro 
             100                105                110
Ala Ala Ala Pro Ala Ala Pro Ser Ala Ser Ala Pro Gly Ser Ser Tyr 
         115                120                125
Pro Val His Met Gln Ile Val Leu Pro Ala Leu Ser Pro Thr Met Thr 
     130                135                140
Met Gly Thr Val Gln Arg Trp Glu Lys Lys Val Gly Glu Lys Leu Ser 
 145                150                155                160
Glu Gly Asp Leu Leu Ala Glu Ile Glu Thr Asp Lys Ala Thr Ile Gly 
                 165                170                175
Phe Glu Val Gln Glu Glu Gly Tyr Leu Ala Lys Ile Leu Val Pro Glu 
             180                185                190
Gly Thr Arg Asp Val Pro Leu Gly Thr Pro Leu Cys Ile Ile Val Glu 
         195                200                205
Lys Gln Glu Asp Ile Ala Ala Phe Ala Asp Tyr Arg Pro Thr Glu Val 
     210                215                220
Thr Ser Leu Lys Pro Gln Ala Pro Pro Pro Val Pro Pro Pro Val Ala 
 225                230                235                240
Ala Val Pro Pro Ile Pro Gln Pro Leu Ala Pro Thr Pro Ser Ala Ala 
                 245                250                255
Pro Ala Gly Pro Lys Gly Arg Val Phe Val Ser Pro Leu Ala Lys Lys 
             260                265                270
Leu Ala Ala Glu Lys Gly Ile Asp Leu Thr Gln Val Lys Gly Thr Gly 
         275                280                285
Pro Glu Gly Arg Ile Ile Lys Lys Asp Ile Asp Ser Phe Val Pro Thr 
     290                295                300
Lys Ala Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro Gly Pro Arg Val 
 305                310                315                320
Ala Pro Thr Pro Ala Gly Val Phe Ile Asp Ile Pro Ile Ser Asn Ile 
                 325                330                335
Arg Arg Val Ile Ala Gln Arg Leu Met Gln Ser Lys Gln Thr Ile Pro 
             340                345                350
His Tyr Tyr Leu Ser Val Asp Val Asn Met Gly Glu Val Leu Leu Val 
         355                360                365
Arg Lys Glu Leu Asn Lys Met Leu Glu Gly Lys Gly Lys Ile Ser Val 
     370                375                380
Asn Asp Phe Ile Ile Lys Ala Ser Ala Leu Ala Cys Leu Lys Val Pro 
 385                390                395                400
Glu Ala Asn Ser Ser Trp Met Asp Thr Val Ile Arg Gln Asn His Val 
                 405                410                415
Val Asp Val Ser Val Ala Val Ser Thr Pro Ala Gly Leu Ile Thr Pro 
             420                425                430
Ile Val Phe Asn Ala His Ile Lys Gly Leu Glu Thr Ile Ala Ser Asp 
         435                440                445
Val Val Ser Leu Ala Ser Lys Ala Arg Glu Gly Lys Leu Gln Pro His 
     450                455                460
Glu Phe Gln Gly Gly Thr Phe Thr Ile Ser Asn Leu Gly Met Phe Gly 
 465                470                475                480
Ile Lys Asn Phe Ser Ala Ile Ile Asn Pro Pro Gln Ala Cys Ile Leu 
                 485                490                495
Ala Ile Gly Ala Ser Glu Asp Lys Leu Ile Pro Ala Asp Asn Glu Lys 
             500                505                510
Gly Phe Asp Val Ala Ser Val Met Ser Val Thr Leu Ser Cys Asp His 
         515                520                525
Arg Val Val Asp Gly Ala Val Gly Ala Gln Trp Leu Ala Glu Phe Lys 
     530                535                540
Lys Tyr Leu Glu Lys Pro Val Thr Met Leu Leu 
 545                550                555



<210> 1593
<211> 2583
<212> DNA
<213> Homo sapiens
<308> Y00978
<400> 1593

cgagtgacc  cgcgatctg  cccggctcc  gctcgtcgc  acagcgtga  tacagggta  60
ggcggggtc  gggcactgt  cggctggac  cccagttct  gggccacgc  gcggaaccg  120
ttactgctg  agcttttgg  gtcgcccgg  cgccgctat  acagtcttc  cccgcatca  180
aaggttcca  tgccttctc  ttcccccac  atgcaggca  gcaccatag  ccgttggaa  240
aaaaaagag  gggacaaaa  caatgaagg  gacctaatt  cagaggttg  aactgataa  300
gccactgtt  gatttgaga  cctggagga  tgttatatg  caaagatac  tgttgctga  360
ggtaccagg  atgttccca  cggagcgat  atctgtatc  cagttggca  gcctgagga  420
attgaggcc  ttaaaaatt  tacactgga  tcctcagca  cacctaccc  acaagcggc  480
ccagcacca  cccctgctg  cactgcttc  ccacctaca  cttctgctc  ggctcctgg  540
agctcatat  cccctcaca  gcaggtact  cttcctgcc  tctctccca  catgaccat  600
ggcacagtt  agagatggg  aaaaaaagt  ggtgagaag  taagtgaag  agacttact  660
gcagagata  aaactgaca  agccactat  ggttttgaa  tacaggaag  aggttatct  720
gcaaaaatc  tggtccctg  aggcacaag  gatgtccct  taggaaccc  actctgtat  780
attgtagaa  aagaggcag  tatatcagc  tttgctgac  ataggccaa  cgaagtaac  840
gatttaaaa  cacaagtgc  accacctac  ccacccccg  tggccgctg  tcctccaac  900
ccccagcct  tagctccta  accttcagc  ccctgccca  ctactcctg  tggaccaaa  960
ggaagggtg  ttgttagcc  tcttgcaaa  aagttggca  tagagaaag  gattgatct  1020
acacaagta  aagggacag  accagatgg  agaatcacc  agaaggata  cgactcttt  1080
gtgcctagt  aagttgctc  tgctccggc  gctgttgtg  ctcccacag  tcctggaat  1140
gcaccagtt  ctacaggtg  cttcacaga  atcccaatc  gcaacattc  tcgggttat  1200
gcacagcga  taatgcaat  aaagcaaac  atacctcat  attaccttt  tatcgatgt  1260
aatatggga  aagttttgt  ggtacggaa  gaacttaat  agatattag  agggagaag  1320
aaaatttct  tcaatgact  catcataaa  gcttcagct  tggcatgtt  aaaagttcc  1380
gaagcaaat  cttcttgga  ggacacagt  ataagacaa  atcatgttg  tgatgtcag  1440
gttgcggtc  gtactcctg  aggactcat  acacctatt  tgtttaatg  acatataaa  1500
ggagtggaa  ccattgcta  tgatgttgt  tctttagca  ccaaagcaa  agagggtaa  1560
ctacagcca  atgaattcc  gggtggcac  tttacgatc  ccaatttag  aatgtttgg  1620
attaagaat  tctctgcta  tattaaccc  cctcaagca  gtattttgg  aattggtgc  1680
tcagaggat  aactggtcc  tgcagataa  gaaaaaggg  ttgatgtgg  tagcatgat  1740
tctgttaca  tcagttgtg  tcaccgggt  gtggatgga  cagttggag  ccagtggct  1800
gctgagttt  gaaagtacc  tgaaaaacc  atcactatg  tgttgtaac  aactcaaga  1860
tttctaaac  ctcccaggt  acactgatt  attcttaac  agatattta  atgttatta  1920
acaggtggt  gctttttat  ttaaccagt  atttttatt  ttgagtctg  tcagataag  1980
tatttataa  gggcattac  gaattttta  aatgccgat  acacccaaa  attgtgcac  2040
tttaataat  agacaccag  tttttagct  tgtactcct  attaaggga  atgtatgtg  2100
ccttgccta  ccctttggt  ataagtact  cctctagga  atgtacgat  ggtagaatt  2160
tggttccct  aagacaagt  cataaaggt  accctgatg  aaccttgaa  ttctgaaat  2220
taactgcct  aaatgttct  cttagatgt  agagaaaga  aaatcagaa  aattaattc  2280
cttggggga  gggcttgaa  tgaagcttt  ctttagaat  tagccctgg  ttgaaattt  2340
ccattacat  atcttggtt  atcatcgat  ggaagggta  aaaacttca  ggaaaataa  2400
tgaaatttt  aaagtcagc  ttttcttag  cctcttcag  tgattgttt  tttttctat  2460
aattctgta  tcaaaatta  acatttgtt  aaataaata  ccacacaaa  tctcagtta  2520
atcaagtag  tggtttata  ttagattat  tcaagtagg  gggaataac  atgtgtagg  2580
att  2583



<210> 1594
<211> 614
<212> PRT
<213> Homo sapiens
<308> P10515
<400> 1594

Met Ser Pro His Cys Ser Thr Thr Tyr Leu Arg Thr Leu Gly Arg Thr 
  1               5                  10                  15
Thr Met Phe Trp Lys Thr Thr Glu Gly Arg Asp Gly Lys Met Ala Val 
             20                  25                  30
Gln Glu Phe Ser Glu Phe Gly Leu Leu Leu Gln Leu Leu Gly Ser Pro 
         35                  40                  45
Gly Arg Arg Tyr Tyr Ser Leu Pro Pro His Gln Lys Val Pro Leu Pro 
     50                  55                  60
Ser Leu Ser Pro Thr Met Gln Ala Gly Thr Ile Ala Arg Trp Glu Lys 
 65                  70                  75                  80
Lys Glu Gly Asp Lys Ile Asn Glu Gly Asp Leu Ile Ala Glu Val Glu 
                 85                  90                  95
Thr Asp Lys Ala Thr Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr Met 
             100                105                110
Ala Lys Ile Leu Val Ala Glu Gly Thr Arg Asp Val Pro Ile Gly Ala 
         115                120                125
Ile Ile Cys Ile Thr Val Gly Lys Pro Glu Asp Ile Glu Ala Phe Lys 
     130                135                140
Asn Tyr Thr Leu Asp Ser Ser Ala Ala Pro Thr Pro Gln Ala Ala Pro 
 145                150                155                160
Ala Pro Thr Pro Ala Ala Thr Ala Ser Pro Pro Thr Pro Ser Ala Gln 
                 165                170                175
Ala Pro Gly Ser Ser Tyr Pro Pro His Met Gln Val Leu Leu Pro Ala 
             180                185                190
Leu Ser Pro Thr Met Thr Met Gly Thr Val Gln Arg Trp Glu Lys Lys 
         195                200                205
Val Gly Glu Lys Leu Ser Glu Gly Asp Leu Leu Ala Glu Ile Glu Thr 
     210                215                220
Asp Lys Ala Thr Ile Gly Phe Glu Val Gln Glu Glu Gly Tyr Leu Ala 
 225                230                235                240
Lys Ile Leu Val Pro Glu Gly Thr Arg Asp Val Pro Leu Gly Thr Pro 
                 245                250                255
Leu Cys Ile Ile Val Glu Lys Glu Ala Asp Ile Ser Ala Phe Ala Asp 
             260                265                270
Tyr Arg Pro Thr Glu Val Thr Asp Leu Lys Pro Gln Val Pro Pro Pro 
         275                280                285
Thr Pro Pro Pro Val Ala Ala Val Pro Pro Thr Pro Gln Pro Leu Ala 
     290                295                300
Pro Thr Pro Ser Thr Pro Cys Pro Ala Thr Pro Ala Gly Pro Lys Gly 
 305                310                315                320
Arg Val Phe Val Asp Pro Leu Ala Lys Lys Leu Ala Val Glu Lys Gly 
                 325                330                335
Ile Asp Leu Thr Gln Val Lys Gly Thr Gly Pro Asp Gly Arg Ile Thr 
             340                345                350
Lys Lys Asp Ile Asp Ser Phe Val Pro Ser Lys Val Ala Pro Ala Pro 
         355                360                365
Ala Ala Val Val Pro Pro Thr Gly Pro Gly Met Ala Pro Val Pro Thr 
     370                375                380
Gly Val Phe Thr Asp Ile Pro Ile Ser Asn Ile Arg Arg Val Ile Ala 
 385                390                395                400
Gln Arg Leu Met Gln Ser Lys Gln Thr Ile Pro His Tyr Tyr Leu Ser 
                 405                410                415
Ile Asp Val Asn Met Gly Glu Val Leu Leu Val Arg Lys Glu Leu Asn 
             420                425                430
Lys Ile Leu Glu Gly Arg Ser Lys Ile Ser Val Asn Asp Phe Ile Ile 
         435                440                445
Lys Ala Ser Ala Leu Ala Cys Leu Lys Val Pro Glu Ala Asn Ser Ser 
     450                455                460
Trp Met Asp Thr Val Ile Arg Gln Asn His Val Val Asp Val Ser Val 
 465                470                475                480
Ala Val Ser Thr Pro Ala Gly Leu Ile Thr Pro Ile Val Phe Asn Ala 
                 485                490                495
His Ile Lys Gly Val Glu Thr Ile Ala Asn Asp Val Val Ser Leu Ala 
             500                505                510
Thr Lys Ala Arg Glu Gly Lys Leu Gln Pro His Glu Phe Gln Gly Gly 
         515                520                525
Thr Phe Thr Ile Ser Asn Leu Gly Met Phe Gly Ile Lys Asn Phe Ser 
     530                535                540
Ala Ile Ile Asn Pro Pro Gln Ala Cys Ile Leu Ala Ile Gly Ala Ser 
 545                550                555                560
Glu Asp Lys Leu Val Pro Ala Asp Asn Glu Lys Gly Phe Asp Val Ala 
                 565                570                575
Ser Met Met Ser Val Thr Leu Ser Cys Asp His Arg Val Val Asp Gly 
             580                585                590
Ala Val Gly Ala Gln Trp Leu Ala Glu Phe Arg Lys Tyr Leu Glu Lys 
         595                600                605
Pro Ile Thr Met Leu Leu 
     610



<210> 1595
<211> 1051
<212> DNA
<213> Rattus norvegicus
<308> D10666
<400> 1595

gggggattc  caatctgca  cagagattc  cccgagcgt  ttgcagcgg  cactgggct  60
gcaaggcgc  atccaagag  gatttaagc  acccggagc  cccagaaaa  aagcgagag  120
gaaccactc  cagagacgg  ttagccgtt  gtctgaatt  aatatatat  tttttttga  180
agaactgtt  agttttatc  ttttcctta  gtgacggtg  acagcgcta  aactgcaaa  240
tggggaaac  gaatagcaa  ctggcccca  aagtcatgg  ggacctggt  aagagcact  300
agttcaatg  gcatgagct  aagcagtgg  acaagggct  cctcaagga  tgtccgagc  360
ggaggctga  tctcgaaga  ttccagcag  tctatgtga  gttcttccc  tatggagat  420
cctccaagt  cgctcagca  gccttccgc  ccttcgaca  gaatggtga  ggcaccatc  480
acttccgag  gttcatctg  gctctgtcc  tcacctcca  aggcagctt  gagcagaaa  540
tgaactggg  tttcaacat  tatgatctg  atggtgacg  caagatcac  agggtggag  600
tgctggaga  tatcgaggc  atctacaag  tggtgggca  tgtgatcat  atgaaaatg  660
atgaggatg  cctcacgcc  gaacagcga  tggacaaga  tttcagcaa  atggataag  720
acaaagatg  ccagattac  ttggatgaa  tcaaagaag  tgcaaaaag  gacccttcc  780
ttgtattac  cctgcagtg  gacattcag  aatgagctg  tgtcaatgc  atggactgc  840
cagaagtct  gatgttcca  tcagtctgc  gctacacac  cacacacac  cacacacac  900
cacacacac  cactacaca  acacacaat  gcttggact  cctataaat  gacttgctt  960
ttgtgtttg  aacacttgt  tgcatgaga  tgtcatttg  taatgaatt  taaaagcat  1020
tattataaa  acccatggt  cccggatcc  c  1051



<210> 1596
<211> 190
<212> PRT
<213> Rattus norvegicus
<308> P28677
<400> 1596

Gly Lys Gln Asn Ser Lys Leu Ala Pro Glu Val Met Glu Asp Leu Val 
  1               5                  10                  15
Lys Ser Thr Glu Phe Asn Glu His Glu Leu Lys Gln Trp Tyr Lys Gly 
             20                  25                  30
Phe Leu Lys Asp Cys Pro Ser Gly Arg Leu Asn Leu Glu Glu Phe Gln 
         35                  40                  45
Gln Leu Tyr Val Lys Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe Ala 
     50                  55                  60
Gln His Ala Phe Arg Thr Phe Asp Lys Asn Gly Asp Gly Thr Ile Asp 
 65                  70                  75                  80
Phe Arg Glu Phe Ile Cys Ala Leu Ser Ile Thr Ser Arg Gly Ser Phe 
                 85                  90                  95
Glu Gln Lys Leu Asn Trp Ala Phe Asn Met Tyr Asp Leu Asp Gly Asp 
             100                105                110
Gly Lys Ile Thr Arg Val Glu Met Leu Glu Ile Ile Glu Ala Ile Tyr 
         115                120                125
Lys Met Val Gly Thr Val Ile Met Met Lys Met Asn Glu Asp Gly Leu 
     130                135                140
Thr Pro Glu Gln Arg Val Asp Lys Ile Phe Ser Lys Met Asp Lys Asn 
 145                150                155                160
Lys Asp Asp Gln Ile Thr Leu Asp Glu Phe Lys Glu Ala Ala Lys Ser 
                 165                170                175
Asp Pro Ser Ile Val Leu Leu Leu Gln Cys Asp Ile Gln Lys 
             180                185                190



<210> 1597
<211> 1559
<212> DNA
<213> Homo sapiens
<308> AF039555
<400> 1597

agcggctgg  cttgcaagg  gcgatccaa  agggattta  gcagcccag  gctccagag  60
aaaagagag  gagagagaa  cacacacag  gacggctta  gcgtttacc  gaattaaat  120
tatattttt  aaaagaact  ttgagtttt  tcattttcg  taagtgacc  tgcgcagcg  180
tgtaactgc  ggatgggga  gcagaatag  aaactggcc  ctgaagtga  ggaggacct  240
gtgaagagc  cagagttta  tgagcatga  ctcaagcag  ggtacaaag  atttctcaa  300
gactgtcca  gtgggaggc  aaatctcga  gaatttcag  agctctatg  gaagttctt  360
ccttatgga  acgcctcca  gtttgccca  catgccttc  gaaccttcg  caagaatgg  420
gacggcacc  ttgacttcc  agagttcat  tgcgctctg  ccatcacct  caggggcag  480
tttgagcag  agctgaact  ggccttcaa  atgtatgac  tggatggtg  tggcaagat  540
acccgagtg  agatgctgg  gatcatcga  gctatctac  aaatggtag  cactgtgat  600
atgatgaaa  tgaatgagg  tggcctgac  cctgagcag  gagtagaca  gattttcag  660
aagatggat  agaacaaag  tgaccagat  acactggat  aattcaaag  agctgcaaa  720
agcgaccct  ccattgtat  acttctgca  tgcgacatc  agaaatgag  tgatgtcaa  780
gctatggac  gcacaaaag  ctcaatgtt  cattcagtc  gcagctatt  acacacaca  840
acacacaca  acacacaca  acacacaca  acacacaca  atattgctt  gactaccta  900
aaatggact  gcttcttgt  tttgaaaca  tcgtgtgca  gagaatgtc  tttgctaat  960
aattttaaa  gcatatata  aacaaaaca  acaacctgc  acaatgtga  atgtgtaat  1020
tcatttcat  aaatccctc  tcctccaaa  cctgggcag  aatgtgctg  aaagagtta  1080
atgacttct  gttcatgtt  tgctaatgc  cgtatctcc  tgattacat  atgttagta  1140
cactgagac  cccatggta  tgtaactta  ttataagct  tgtcactac  ctcctgtaa  1200
atactattg  acagacaca  agggaccct  ggctcctgt  tctggtcca  acaccacag  1260
agcttgtat  atcagtgaa  ataaatgta  tacatttgc  tgccttttg  gtttgcctt  1320
attcttacc  catttgcat  ctatcgatc  ggaaagagc  gttttggat  aatgcagta  1380
aaaatgtaa  aaccctgct  aatgactta  tgattaagt  tatctatct  tatatacat  1440
tacacaaag  tattattta  cgaaagtaa  aaagatgga  gtgtattgg  ttctgtttg  1500
attttcaaa  gcttccaat  tggtggcaa  aaatgtccc  aataaattt  taacaattg  1559



<210> 1598
<211> 190
<212> PRT
<213> Homo sapiens
<308> P28677
<400> 1598

Gly Lys Gln Asn Ser Lys Leu Ala Pro Glu Val Met Glu Asp Leu Val 
  1               5                  10                  15
Lys Ser Thr Glu Phe Asn Glu His Glu Leu Lys Gln Trp Tyr Lys Gly 
             20                  25                  30
Phe Leu Lys Asp Cys Pro Ser Gly Arg Leu Asn Leu Glu Glu Phe Gln 
         35                  40                  45
Gln Leu Tyr Val Lys Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe Ala 
     50                  55                  60
Gln His Ala Phe Arg Thr Phe Asp Lys Asn Gly Asp Gly Thr Ile Asp 
 65                  70                  75                  80
Phe Arg Glu Phe Ile Cys Ala Leu Ser Ile Thr Ser Arg Gly Ser Phe 
                 85                  90                  95
Glu Gln Lys Leu Asn Trp Ala Phe Asn Met Tyr Asp Leu Asp Gly Asp 
             100                105                110
Gly Lys Ile Thr Arg Val Glu Met Leu Glu Ile Ile Glu Ala Ile Tyr 
         115                120                125
Lys Met Val Gly Thr Val Ile Met Met Lys Met Asn Glu Asp Gly Leu 
     130                135                140
Thr Pro Glu Gln Arg Val Asp Lys Ile Phe Ser Lys Met Asp Lys Asn 
 145                150                155                160
Lys Asp Asp Gln Ile Thr Leu Asp Glu Phe Lys Glu Ala Ala Lys Ser 
                 165                170                175
Asp Pro Ser Ile Val Leu Leu Leu Gln Cys Asp Ile Gln Lys 
             180                185                190



<210> 1600
<211> 226
<212> PRT
<213> Rattus norvegicus
<308> BAA01549
<400> 1600

Val Lys Ser Ser Leu Gln Arg Ile Leu Asn Ser His Cys Phe Ala Arg 
  1               5                  10                  15
Glu Lys Glu Gly Asp Lys Arg Ser Ala Thr Leu His Ala Ser Arg Thr 
             20                  25                  30
Met Pro Leu Leu Ser Gln His Ser Arg Gly Gly Cys Ser Ser Glu Ser 
         35                  40                  45
Ser Arg Val Ala Leu His Cys Cys Ser Asn Leu Gly Pro Gly Pro Arg 
     50                  55                  60
Trp Cys Ser Asp Val Pro His Pro Pro Leu Lys Ile Pro Gly Gly Arg 
 65                  70                  75                  80
Gly Asn Ser Gln Arg Asp His Ser Leu Ser Ala Ser Ile Leu Tyr Ser 
                 85                  90                  95
Asp Glu Arg Leu Asn Val Thr Glu Glu Pro Thr Ser Asn Asp Lys Thr 
             100                105                110
Arg Val Leu Ser Ile Gln Cys Thr Leu Thr Glu Ala Lys Gln Val Thr 
         115                120                125
Trp Arg Ala Val Trp Asn Gly Gly Gly Leu Tyr Ile Glu Leu Pro Ala 
     130                135                140
Gly Pro Leu Pro Glu Gly Ser Lys Asp Ser Phe Ala Ala Leu Leu Glu 
 145                150                155                160
Phe Ala Glu Glu Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe Pro 
                 165                170                175
Lys Asn Arg Glu Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe Leu 
             180                185                190
Gly Phe Glu Ile Val Arg Pro Gly His Pro Leu Val Pro Lys Arg Pro 
         195                200                205
Asp Ala Cys Phe Met Val Tyr Thr Leu Glu Arg Glu Asp Pro Gly Glu 
     210                215                220
Glu Asp 
 225



<210> 1602
<211> 228
<212> PRT
<213> Homo sapiens
<308> NP_004143
<400> 1602

Met Val Lys Ser Ser Leu Gln Arg Ile Leu Asn Ser His Cys Phe Ala 
  1               5                  10                  15
Arg Glu Lys Glu Gly Asp Lys Pro Ser Ala Thr Ile His Ala Ser Arg 
             20                  25                  30
Thr Met Pro Leu Leu Ser Leu His Ser Arg Gly Gly Ser Ser Ser Glu 
         35                  40                  45
Ser Ser Arg Val Ser Leu His Cys Cys Ser Asn Pro Gly Pro Gly Pro 
     50                  55                  60
Arg Trp Cys Ser Asp Ala Pro His Pro Pro Leu Lys Ile Pro Gly Gly 
 65                  70                  75                  80
Arg Gly Asn Ser Gln Arg Asp His Asn Leu Ser Ala Asn Leu Phe Tyr 
                 85                  90                  95
Ser Asp Asp Arg Leu Asn Val Thr Glu Glu Leu Thr Ser Asn Asp Lys 
             100                105                110
Thr Arg Ile Leu Asn Val Gln Ser Arg Leu Thr Asp Ala Lys Arg Ile 
         115                120                125
Asn Trp Arg Thr Val Leu Ser Gly Gly Ser Leu Tyr Ile Glu Ile Pro 
     130                135                140
Gly Gly Ala Leu Pro Glu Gly Ser Lys Asp Ser Phe Ala Val Leu Leu 
 145                150                155                160
Glu Phe Ala Glu Glu Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe 
                 165                170                175
His Lys Asn Arg Glu Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe 
             180                185                190
Leu Gly Phe Glu Ile Val Arg Pro Gly His Pro Leu Val Pro Lys Arg 
         195                200                205
Pro Asp Ala Cys Phe Met Ala Tyr Thr Phe Glu Arg Glu Ser Ser Gly 
     210                215                220
Glu Glu Glu Glu 
 225



<210> 1604
<211> 226
<212> PRT
<213> Rattus norvegicus
<308> BAA01549
<400> 1604

Val Lys Ser Ser Leu Gln Arg Ile Leu Asn Ser His Cys Phe Ala Arg 
  1               5                  10                  15
Glu Lys Glu Gly Asp Lys Arg Ser Ala Thr Leu His Ala Ser Arg Thr 
             20                  25                  30
Met Pro Leu Leu Ser Gln His Ser Arg Gly Gly Cys Ser Ser Glu Ser 
         35                  40                  45
Ser Arg Val Ala Leu His Cys Cys Ser Asn Leu Gly Pro Gly Pro Arg 
     50                  55                  60
Trp Cys Ser Asp Val Pro His Pro Pro Leu Lys Ile Pro Gly Gly Arg 
 65                  70                  75                  80
Gly Asn Ser Gln Arg Asp His Ser Leu Ser Ala Ser Ile Leu Tyr Ser 
                 85                  90                  95
Asp Glu Arg Leu Asn Val Thr Glu Glu Pro Thr Ser Asn Asp Lys Thr 
             100                105                110
Arg Val Leu Ser Ile Gln Cys Thr Leu Thr Glu Ala Lys Gln Val Thr 
         115                120                125
Trp Arg Ala Val Trp Asn Gly Gly Gly Leu Tyr Ile Glu Leu Pro Ala 
     130                135                140
Gly Pro Leu Pro Glu Gly Ser Lys Asp Ser Phe Ala Ala Leu Leu Glu 
 145                150                155                160
Phe Ala Glu Glu Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe Pro 
                 165                170                175
Lys Asn Arg Glu Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe Leu 
             180                185                190
Gly Phe Glu Ile Val Arg Pro Gly His Pro Leu Val Pro Lys Arg Pro 
         195                200                205
Asp Ala Cys Phe Met Val Tyr Thr Leu Glu Arg Glu Asp Pro Gly Glu 
     210                215                220
Glu Asp 
 225



<210> 1606
<211> 228
<212> PRT
<213> Homo sapiens
<308> NP_004143
<400> 1606

Met Val Lys Ser Ser Leu Gln Arg Ile Leu Asn Ser His Cys Phe Ala 
  1               5                  10                  15
Arg Glu Lys Glu Gly Asp Lys Pro Ser Ala Thr Ile His Ala Ser Arg 
             20                  25                  30
Thr Met Pro Leu Leu Ser Leu His Ser Arg Gly Gly Ser Ser Ser Glu 
         35                  40                  45
Ser Ser Arg Val Ser Leu His Cys Cys Ser Asn Pro Gly Pro Gly Pro 
     50                  55                  60
Arg Trp Cys Ser Asp Ala Pro His Pro Pro Leu Lys Ile Pro Gly Gly 
 65                  70                  75                  80
Arg Gly Asn Ser Gln Arg Asp His Asn Leu Ser Ala Asn Leu Phe Tyr 
                 85                  90                  95
Ser Asp Asp Arg Leu Asn Val Thr Glu Glu Leu Thr Ser Asn Asp Lys 
             100                105                110
Thr Arg Ile Leu Asn Val Gln Ser Arg Leu Thr Asp Ala Lys Arg Ile 
         115                120                125
Asn Trp Arg Thr Val Leu Ser Gly Gly Ser Leu Tyr Ile Glu Ile Pro 
     130                135                140
Gly Gly Ala Leu Pro Glu Gly Ser Lys Asp Ser Phe Ala Val Leu Leu 
 145                150                155                160
Glu Phe Ala Glu Glu Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe 
                 165                170                175
His Lys Asn Arg Glu Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe 
             180                185                190
Leu Gly Phe Glu Ile Val Arg Pro Gly His Pro Leu Val Pro Lys Arg 
         195                200                205
Pro Asp Ala Cys Phe Met Ala Tyr Thr Phe Glu Arg Glu Ser Ser Gly 
     210                215                220
Glu Glu Glu Glu 
 225



<210> 1608
<211> 226
<212> PRT
<213> Rattus norvegicus
<308> BAA01549
<400> 1608

Val Lys Ser Ser Leu Gln Arg Ile Leu Asn Ser His Cys Phe Ala Arg 
  1               5                  10                  15
Glu Lys Glu Gly Asp Lys Arg Ser Ala Thr Leu His Ala Ser Arg Thr 
             20                  25                  30
Met Pro Leu Leu Ser Gln His Ser Arg Gly Gly Cys Ser Ser Glu Ser 
         35                  40                  45
Ser Arg Val Ala Leu His Cys Cys Ser Asn Leu Gly Pro Gly Pro Arg 
     50                  55                  60
Trp Cys Ser Asp Val Pro His Pro Pro Leu Lys Ile Pro Gly Gly Arg 
 65                  70                  75                  80
Gly Asn Ser Gln Arg Asp His Ser Leu Ser Ala Ser Ile Leu Tyr Ser 
                 85                  90                  95
Asp Glu Arg Leu Asn Val Thr Glu Glu Pro Thr Ser Asn Asp Lys Thr 
             100                105                110
Arg Val Leu Ser Ile Gln Cys Thr Leu Thr Glu Ala Lys Gln Val Thr 
         115                120                125
Trp Arg Ala Val Trp Asn Gly Gly Gly Leu Tyr Ile Glu Leu Pro Ala 
     130                135                140
Gly Pro Leu Pro Glu Gly Ser Lys Asp Ser Phe Ala Ala Leu Leu Glu 
 145                150                155                160
Phe Ala Glu Glu Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe Pro 
                 165                170                175
Lys Asn Arg Glu Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe Leu 
             180                185                190
Gly Phe Glu Ile Val Arg Pro Gly His Pro Leu Val Pro Lys Arg Pro 
         195                200                205
Asp Ala Cys Phe Met Val Tyr Thr Leu Glu Arg Glu Asp Pro Gly Glu 
     210                215                220
Glu Asp 
 225



<210> 1610
<211> 228
<212> PRT
<213> Homo sapiens
<308> NP_004143
<400> 1610

Met Val Lys Ser Ser Leu Gln Arg Ile Leu Asn Ser His Cys Phe Ala 
  1               5                  10                  15
Arg Glu Lys Glu Gly Asp Lys Pro Ser Ala Thr Ile His Ala Ser Arg 
             20                  25                  30
Thr Met Pro Leu Leu Ser Leu His Ser Arg Gly Gly Ser Ser Ser Glu 
         35                  40                  45
Ser Ser Arg Val Ser Leu His Cys Cys Ser Asn Pro Gly Pro Gly Pro 
     50                  55                  60
Arg Trp Cys Ser Asp Ala Pro His Pro Pro Leu Lys Ile Pro Gly Gly 
 65                  70                  75                  80
Arg Gly Asn Ser Gln Arg Asp His Asn Leu Ser Ala Asn Leu Phe Tyr 
                 85                  90                  95
Ser Asp Asp Arg Leu Asn Val Thr Glu Glu Leu Thr Ser Asn Asp Lys 
             100                105                110
Thr Arg Ile Leu Asn Val Gln Ser Arg Leu Thr Asp Ala Lys Arg Ile 
         115                120                125
Asn Trp Arg Thr Val Leu Ser Gly Gly Ser Leu Tyr Ile Glu Ile Pro 
     130                135                140
Gly Gly Ala Leu Pro Glu Gly Ser Lys Asp Ser Phe Ala Val Leu Leu 
 145                150                155                160
Glu Phe Ala Glu Glu Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe 
                 165                170                175
His Lys Asn Arg Glu Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe 
             180                185                190
Leu Gly Phe Glu Ile Val Arg Pro Gly His Pro Leu Val Pro Lys Arg 
         195                200                205
Pro Asp Ala Cys Phe Met Ala Tyr Thr Phe Glu Arg Glu Ser Ser Gly 
     210                215                220
Glu Glu Glu Glu 
 225



<210> 1612
<211> 226
<212> PRT
<213> Rattus norvegicus
<308> BAA01549
<400> 1612

Val Lys Ser Ser Leu Gln Arg Ile Leu Asn Ser His Cys Phe Ala Arg 
  1               5                  10                  15
Glu Lys Glu Gly Asp Lys Arg Ser Ala Thr Leu His Ala Ser Arg Thr 
             20                  25                  30
Met Pro Leu Leu Ser Gln His Ser Arg Gly Gly Cys Ser Ser Glu Ser 
         35                  40                  45
Ser Arg Val Ala Leu His Cys Cys Ser Asn Leu Gly Pro Gly Pro Arg 
     50                  55                  60
Trp Cys Ser Asp Val Pro His Pro Pro Leu Lys Ile Pro Gly Gly Arg 
 65                  70                  75                  80
Gly Asn Ser Gln Arg Asp His Ser Leu Ser Ala Ser Ile Leu Tyr Ser 
                 85                  90                  95
Asp Glu Arg Leu Asn Val Thr Glu Glu Pro Thr Ser Asn Asp Lys Thr 
             100                105                110
Arg Val Leu Ser Ile Gln Cys Thr Leu Thr Glu Ala Lys Gln Val Thr 
         115                120                125
Trp Arg Ala Val Trp Asn Gly Gly Gly Leu Tyr Ile Glu Leu Pro Ala 
     130                135                140
Gly Pro Leu Pro Glu Gly Ser Lys Asp Ser Phe Ala Ala Leu Leu Glu 
 145                150                155                160
Phe Ala Glu Glu Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe Pro 
                 165                170                175
Lys Asn Arg Glu Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe Leu 
             180                185                190
Gly Phe Glu Ile Val Arg Pro Gly His Pro Leu Val Pro Lys Arg Pro 
         195                200                205
Asp Ala Cys Phe Met Val Tyr Thr Leu Glu Arg Glu Asp Pro Gly Glu 
     210                215                220
Glu Asp 
 225



<210> 1614
<211> 228
<212> PRT
<213> Homo sapiens
<308> NP_004143
<400> 1614

Met Val Lys Ser Ser Leu Gln Arg Ile Leu Asn Ser His Cys Phe Ala 
  1               5                  10                  15
Arg Glu Lys Glu Gly Asp Lys Pro Ser Ala Thr Ile His Ala Ser Arg 
             20                  25                  30
Thr Met Pro Leu Leu Ser Leu His Ser Arg Gly Gly Ser Ser Ser Glu 
         35                  40                  45
Ser Ser Arg Val Ser Leu His Cys Cys Ser Asn Pro Gly Pro Gly Pro 
     50                  55                  60
Arg Trp Cys Ser Asp Ala Pro His Pro Pro Leu Lys Ile Pro Gly Gly 
 65                  70                  75                  80
Arg Gly Asn Ser Gln Arg Asp His Asn Leu Ser Ala Asn Leu Phe Tyr 
                 85                  90                  95
Ser Asp Asp Arg Leu Asn Val Thr Glu Glu Leu Thr Ser Asn Asp Lys 
             100                105                110
Thr Arg Ile Leu Asn Val Gln Ser Arg Leu Thr Asp Ala Lys Arg Ile 
         115                120                125
Asn Trp Arg Thr Val Leu Ser Gly Gly Ser Leu Tyr Ile Glu Ile Pro 
     130                135                140
Gly Gly Ala Leu Pro Glu Gly Ser Lys Asp Ser Phe Ala Val Leu Leu 
 145                150                155                160
Glu Phe Ala Glu Glu Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe 
                 165                170                175
His Lys Asn Arg Glu Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe 
             180                185                190
Leu Gly Phe Glu Ile Val Arg Pro Gly His Pro Leu Val Pro Lys Arg 
         195                200                205
Pro Asp Ala Cys Phe Met Ala Tyr Thr Phe Glu Arg Glu Ser Ser Gly 
     210                215                220
Glu Glu Glu Glu 
 225



<210> 1616
<211> 226
<212> PRT
<213> Rattus norvegicus
<308> BAA01549
<400> 1616

Val Lys Ser Ser Leu Gln Arg Ile Leu Asn Ser His Cys Phe Ala Arg 
  1               5                  10                  15
Glu Lys Glu Gly Asp Lys Arg Ser Ala Thr Leu His Ala Ser Arg Thr 
             20                  25                  30
Met Pro Leu Leu Ser Gln His Ser Arg Gly Gly Cys Ser Ser Glu Ser 
         35                  40                  45
Ser Arg Val Ala Leu His Cys Cys Ser Asn Leu Gly Pro Gly Pro Arg 
     50                  55                  60
Trp Cys Ser Asp Val Pro His Pro Pro Leu Lys Ile Pro Gly Gly Arg 
 65                  70                  75                  80
Gly Asn Ser Gln Arg Asp His Ser Leu Ser Ala Ser Ile Leu Tyr Ser 
                 85                  90                  95
Asp Glu Arg Leu Asn Val Thr Glu Glu Pro Thr Ser Asn Asp Lys Thr 
             100                105                110
Arg Val Leu Ser Ile Gln Cys Thr Leu Thr Glu Ala Lys Gln Val Thr 
         115                120                125
Trp Arg Ala Val Trp Asn Gly Gly Gly Leu Tyr Ile Glu Leu Pro Ala 
     130                135                140
Gly Pro Leu Pro Glu Gly Ser Lys Asp Ser Phe Ala Ala Leu Leu Glu 
 145                150                155                160
Phe Ala Glu Glu Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe Pro 
                 165                170                175
Lys Asn Arg Glu Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe Leu 
             180                185                190
Gly Phe Glu Ile Val Arg Pro Gly His Pro Leu Val Pro Lys Arg Pro 
         195                200                205
Asp Ala Cys Phe Met Val Tyr Thr Leu Glu Arg Glu Asp Pro Gly Glu 
     210                215                220
Glu Asp 
 225



<210> 1618
<211> 228
<212> PRT
<213> Homo sapiens
<308> NP_004143
<400> 1618

Met Val Lys Ser Ser Leu Gln Arg Ile Leu Asn Ser His Cys Phe Ala 
  1               5                  10                  15
Arg Glu Lys Glu Gly Asp Lys Pro Ser Ala Thr Ile His Ala Ser Arg 
             20                  25                  30
Thr Met Pro Leu Leu Ser Leu His Ser Arg Gly Gly Ser Ser Ser Glu 
         35                  40                  45
Ser Ser Arg Val Ser Leu His Cys Cys Ser Asn Pro Gly Pro Gly Pro 
     50                  55                  60
Arg Trp Cys Ser Asp Ala Pro His Pro Pro Leu Lys Ile Pro Gly Gly 
 65                  70                  75                  80
Arg Gly Asn Ser Gln Arg Asp His Asn Leu Ser Ala Asn Leu Phe Tyr 
                 85                  90                  95
Ser Asp Asp Arg Leu Asn Val Thr Glu Glu Leu Thr Ser Asn Asp Lys 
             100                105                110
Thr Arg Ile Leu Asn Val Gln Ser Arg Leu Thr Asp Ala Lys Arg Ile 
         115                120                125
Asn Trp Arg Thr Val Leu Ser Gly Gly Ser Leu Tyr Ile Glu Ile Pro 
     130                135                140
Gly Gly Ala Leu Pro Glu Gly Ser Lys Asp Ser Phe Ala Val Leu Leu 
 145                150                155                160
Glu Phe Ala Glu Glu Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe 
                 165                170                175
His Lys Asn Arg Glu Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe 
             180                185                190
Leu Gly Phe Glu Ile Val Arg Pro Gly His Pro Leu Val Pro Lys Arg 
         195                200                205
Pro Asp Ala Cys Phe Met Ala Tyr Thr Phe Glu Arg Glu Ser Ser Gly 
     210                215                220
Glu Glu Glu Glu 
 225



<210> 1620
<211> 226
<212> PRT
<213> Rattus norvegicus
<308> BAA01549
<400> 1620

Val Lys Ser Ser Leu Gln Arg Ile Leu Asn Ser His Cys Phe Ala Arg 
  1               5                  10                  15
Glu Lys Glu Gly Asp Lys Arg Ser Ala Thr Leu His Ala Ser Arg Thr 
             20                  25                  30
Met Pro Leu Leu Ser Gln His Ser Arg Gly Gly Cys Ser Ser Glu Ser 
         35                  40                  45
Ser Arg Val Ala Leu His Cys Cys Ser Asn Leu Gly Pro Gly Pro Arg 
     50                  55                  60
Trp Cys Ser Asp Val Pro His Pro Pro Leu Lys Ile Pro Gly Gly Arg 
 65                  70                  75                  80
Gly Asn Ser Gln Arg Asp His Ser Leu Ser Ala Ser Ile Leu Tyr Ser 
                 85                  90                  95
Asp Glu Arg Leu Asn Val Thr Glu Glu Pro Thr Ser Asn Asp Lys Thr 
             100                105                110
Arg Val Leu Ser Ile Gln Cys Thr Leu Thr Glu Ala Lys Gln Val Thr 
         115                120                125
Trp Arg Ala Val Trp Asn Gly Gly Gly Leu Tyr Ile Glu Leu Pro Ala 
     130                135                140
Gly Pro Leu Pro Glu Gly Ser Lys Asp Ser Phe Ala Ala Leu Leu Glu 
 145                150                155                160
Phe Ala Glu Glu Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe Pro 
                 165                170                175
Lys Asn Arg Glu Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe Leu 
             180                185                190
Gly Phe Glu Ile Val Arg Pro Gly His Pro Leu Val Pro Lys Arg Pro 
         195                200                205
Asp Ala Cys Phe Met Val Tyr Thr Leu Glu Arg Glu Asp Pro Gly Glu 
     210                215                220
Glu Asp 
 225



<210> 1622
<211> 228
<212> PRT
<213> Homo sapiens
<308> NP_004143
<400> 1622

Met Val Lys Ser Ser Leu Gln Arg Ile Leu Asn Ser His Cys Phe Ala 
  1               5                  10                  15
Arg Glu Lys Glu Gly Asp Lys Pro Ser Ala Thr Ile His Ala Ser Arg 
             20                  25                  30
Thr Met Pro Leu Leu Ser Leu His Ser Arg Gly Gly Ser Ser Ser Glu 
         35                  40                  45
Ser Ser Arg Val Ser Leu His Cys Cys Ser Asn Pro Gly Pro Gly Pro 
     50                  55                  60
Arg Trp Cys Ser Asp Ala Pro His Pro Pro Leu Lys Ile Pro Gly Gly 
 65                  70                  75                  80
Arg Gly Asn Ser Gln Arg Asp His Asn Leu Ser Ala Asn Leu Phe Tyr 
                 85                  90                  95
Ser Asp Asp Arg Leu Asn Val Thr Glu Glu Leu Thr Ser Asn Asp Lys 
             100                105                110
Thr Arg Ile Leu Asn Val Gln Ser Arg Leu Thr Asp Ala Lys Arg Ile 
         115                120                125
Asn Trp Arg Thr Val Leu Ser Gly Gly Ser Leu Tyr Ile Glu Ile Pro 
     130                135                140
Gly Gly Ala Leu Pro Glu Gly Ser Lys Asp Ser Phe Ala Val Leu Leu 
 145                150                155                160
Glu Phe Ala Glu Glu Gln Leu Arg Ala Asp His Val Phe Ile Cys Phe 
                 165                170                175
His Lys Asn Arg Glu Asp Arg Ala Ala Leu Leu Arg Thr Phe Ser Phe 
             180                185                190
Leu Gly Phe Glu Ile Val Arg Pro Gly His Pro Leu Val Pro Lys Arg 
         195                200                205
Pro Asp Ala Cys Phe Met Ala Tyr Thr Phe Glu Arg Glu Ser Ser Gly 
     210                215                220
Glu Glu Glu Glu 
 225



<210> 1623
<211> 1018
<212> DNA
<213> Rattus norvegicus
<308> D10729
<400> 1623

aaataaaaa  ttatatttt  ctttttggatctgtg  ggcgctcct  gggggcagc  gccgagtgg  cttgccgtg  atgcagaag  60
gcttcgctc  gacccggga  actacagtt  ctccgtgca  gctccggag  tcgcgcttc  120
ccggggaat  cagcccact  aattcctga  gtcctttgg  gatgaccag  aaaggaagg  180
tcagattga  atggcgcat  gcacaacca  gctggcctt  aaattccag  atggagtca  240
cgtggctgt  gactccagg  cctctgcag  gagttacat  gctaccata  gggtgaaca  300
ggtgatcga  attaaccct  acctgcttg  aactatgtc  ggttgtgca  ccgactgtc  360
gtactggga  aggctgttg  ccaaggaat  caggctata  tatctgcgg  atggggaac  420
catctccgt  tctgcagcc  ccaagctac  ttccaacat  atgctgcag  accggggta  480
gggcctctc  atgggcagc  tgatctgcg  ctgggacaa  aagggaccg  gactttatt  540
cgtagatga  aatgggact  ggctctcgg  acagatgtt  tccacaggc  gcgggaaca  600
ctatgccta  ggggtgatg  acagtgggt  ccggcagga  ctcagtcct  aggaggcct  660
cgaccttgc  cgaagagct  ttgtttatg  tacccacag  gacagctat  ctggaggag  720
tgtcaacat  taccacatg  agaaagacg  ttgggtgaa  gtggagagc  ctgacgtca  780
tgacctgtt  cacaagtac  gagaggcca  tctgtgatc  ctgctgggc  gacatcctc  840
cggccctga  gagctggca  actcaggga  ctggggcta  ttcagtctt  ggagaaaga  900
gggcccaac  tgggctgga  acaaagctc  gaggctatg  agacatctt  gtttaccct  960
tcactcagc  agccctcac  gataccttc  aagtacaat  aaagaaaaa  agttctac  1018



<210> 1624
<211> 271
<212> PRT
<213> Rattus norvegicus
<308> BAA01572
<400> 1624

Asp Ser Cys Gly Ala Pro Arg Gly Gln Arg Pro Ser Gly Leu Ala Val 
  1               5                  10                  15
Asp Ala Glu Gly Leu Arg Ser Asp Pro Gly His Tyr Ser Phe Ser Val 
             20                  25                  30
Gln Ala Pro Glu Leu Ala Leu Pro Arg Gly Met Gln Pro Thr Glu Phe 
         35                  40                  45
Ser Arg Ser Phe Gly Asp Asp Gln Glu Arg Lys Val Gln Ile Glu Met 
     50                  55                  60
Ala His Gly Thr Thr Thr Leu Ala Phe Lys Phe Gln His Gly Val Ile 
 65                  70                  75                  80
Val Ala Val Asp Ser Arg Ala Ser Ala Gly Ser Tyr Ile Ala Thr Ile 
                 85                  90                  95
Arg Val Asn Lys Val Ile Glu Ile Asn Pro Tyr Leu Leu Gly Thr Met 
             100                105                110
Ser Gly Cys Ala Ala Asp Cys Gln Tyr Trp Glu Arg Leu Leu Ala Lys 
         115                120                125
Glu Cys Arg Leu Tyr Tyr Leu Arg Asn Gly Glu Arg Ile Ser Val Ser 
     130                135                140
Ala Ala Ser Lys Leu Leu Ser Asn Met Met Leu Gln Tyr Arg Gly Met 
 145                150                155                160
Gly Leu Ser Met Gly Ser Met Ile Cys Gly Trp Asp Lys Lys Gly Pro 
                 165                170                175
Gly Leu Tyr Tyr Val Asp Asp Asn Gly Thr Arg Leu Ser Gly Gln Met 
             180                185                190
Phe Ser Thr Gly Ser Gly Asn Thr Tyr Ala Tyr Gly Val Met Asp Ser 
         195                200                205
Gly Tyr Arg Gln Asp Leu Ser Pro Glu Glu Ala Tyr Asp Leu Ala Arg 
     210                215                220
Arg Ala Ile Val Tyr Ala Thr His Arg Asp Ser Tyr Ser Gly Gly Val 
 225                230                235                240
Val Asn Met Tyr His Met Lys Lys Asp Gly Trp Val Lys Val Glu Ser 
                 245                250                255
Thr Asp Val Ser Asp Leu Leu His Lys Tyr Arg Glu Ala Thr Leu 
             260                265                270



<210> 1625
<211> 1122
<212> DNA
<213> Rattus norvegicus
<308> D10770
<400> 1625

gggacggcc  cggtcccct  ccctccgtc  ctcctgctt  cggactccc  ggtcatggg  60
aacacggcg  tcgccaaga  aggcagcga  gtggagagc  tgaaagaat  cctagccaa  120
gccaaagaa  actttctga  gaaatggga  aaccctccc  cgagtaatg  tgggcttga  180
gattttgaa  ggaaaaaaa  ccttggaac  ggttccttc  gaagagtca  gctggtaaa  240
cataaagcc  ctgagcagt  ctacgccat  aagatctta  acaagcaga  ggtcgttaa  300
ctaaagcaa  tagagcaca  tctgaatga  aagagaatc  tgcaggcag  ggagttccc  360
ttccttgtt  ggctggagt  ttcttttaa  gataattct  atttataca  ggttatgga  420
tacgttcct  ggggggaaa  gttttcaca  ctaagaaga  ttggaaggt  cagtgaacc  480
catgctcgt  tctatgcag  tcagatcgt  ctaacattt  agtacctcc  ttccctcga  540
ctcatctac  gagatctca  gccggaaaa  ctcttaatt  accaccagg  ttacatcca  600
gtcacagat  ttgggttcg  caagagagt  aagggcagg  cttggacat  gtgtggcac  660
ccagagtac  tggccccag  gatcatcct  agcaagggt  acaataagg  agtggactg  720
tgggcattg  gtgtactga  ctacgagat  gctgctggc  accccccgt  ctttgctga  780
cagccaatt  agatttatg  gaagattgt  tccggaaag  tccgcttcc  gtcgcactt  840
agttccgat  tcaaggacc  tctgcggaa  ctgctgcag  tggatctga  aaagcggtt  900
gggaacctg  agaatggcg  gagtgacat  aagacccac  agtggtttg  tacgaccga  960
tggatcgcg  tttaccaga  aaaggttga  gctccattc  taccaaaat  cagaggctc  1020
ggcgatacc  gcaacttcg  tgactatga  gaagaagaa  tccgagtgt  tataacaga  1080
aaatgtgga  aggagtttt  tgaatttta  ggaggagaa  ga  1122



<210> 1626
<211> 350
<212> PRT
<213> Rattus norvegicus
<308> BAA01601
<400> 1626

Gly Asn Thr Ala Ile Ala Lys Lys Gly Ser Glu Val Glu Ser Val Lys 
  1               5                  10                  15
Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Arg Lys Trp Glu Asn 
             20                  25                  30
Pro Pro Pro Ser Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys Thr 
         35                  40                  45
Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys Ala 
     50                  55                  60
Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val Val 
 65                  70                  75                  80
Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu Gln 
                 85                  90                  95
Ala Val Glu Phe Pro Phe Leu Val Arg Leu Glu Tyr Ser Phe Lys Asp 
             100                105                110
Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu Met 
         115                120                125
Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala Arg 
     130                135                140
Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser Leu 
 145                150                155                160
Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp His 
                 165                170                175
Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val Lys 
             180                185                190
Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
         195                200                205
Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala Leu 
     210                215                220
Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe Ala 
 225                230                235                240
Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val Arg 
                 245                250                255
Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn Leu 
             260                265                270
Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly Val 
         275                280                285
Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp Trp Ile Ala 
     290                295                300
Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Arg Gly 
 305                310                315                320
Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Glu Ile Arg 
                 325                330                335
Val Ser Ile Thr Glu Lys Cys Gly Lys Glu Phe Cys Glu Phe 
             340                345                350



<210> 1627
<211> 2945
<212> DNA
<213> Homo sapiens
<308> NM_002731
<400> 1627

ccagccccc  ttcccttcc  tgacccctt  ttgccatcg  cccagacat  gggaacgcg  60
cgaccgcca  gaaaggcag  gaggtggag  gcgtgaaag  gtttctagc  aaagccaaa  120
aagactttt  gaaaaaatg  gagaatcca  ctcagaata  tgccggact  gaagatttt  180
aaaggaaaa  aacccttgg  acaggttca  ttggaagag  catgttggt  aaacacaaa  240
ccactgaac  gtattatgc  atgaagatc  tagataagc  gaaggttgt  aaactgaag  300
aaatagagc  tactttgaa  gagaaaaga  tattacagg  agtgaattt  cctttcctt  360
ttcgactgg  gtatgcttt  aaggataat  ctaatttat  catggttat  gaatatgtc  420
ctgggggtg  aatgttttc  catctaaga  gaattggaa  gttcagtga  ccccatgca  480
ggttctatg  agctcagat  gtgctaaca  tcgagtacc  ccattcact  gacctcatc  540
acagagatc  aaaacctga  aatctctta  ttgaccatc  aggctatat  caggtcaca  600
actttgggt  tgccaaaag  gttaaaggc  gaacttgga  attatgtgg  actccagag  660
atttggctc  agaaataat  ctcagcaag  gctacaata  ggcagtgga  tggtgggca  720
taggagtgc  aatctatga  atggcagct  gctatcccc  attctttgc  gaccaacca  780
ttcagattt  tgaaaagat  gtttctgga  aggtccgat  cccatccca  ttcagttca  840
atctcaagg  ccttctacg  aacctgctg  aggtggatt  gaccaagag  tttggaaat  900
taaagaatg  tgtcagtga  ataaaaact  acaagtggt  tgccacgac  gattggatt  960
ctatttacc  gaggaaggt  gaagctcca  tcataccaa  gtttagagg  tctggagat  1020
ccagcaact  tgatgacta  gaagaagaa  atatccgtg  ctctataac  gaaaaatgt  1080
caaaagaat  tggtgaatt  taaagagga  caagatgac  tctgagctc  cactcagtg  1140
ttgcactct  ttgagagat  aggtagagc  gagaccgtc  ttgttgaag  agttaccta  1200
ttccttcat  ccaacgact  agtgaggtc  ttattgcca  catccgtgt  cgcactctg  1260
atccaccta  gtaacaagg  accgctaag  aagcattgt  tgtgccata  cacagtact  1320
gaccacttt  ttacttctc  ttgggttgt  tttctcctc  cctacatcc  tttcttcct  1380
ttcaatttc  ttggttttc  ctaaacagt  ctccatttt  ttttgttgg  gtttcagat  1440
ggcagtgtt  tggctacgt  atatttgaa  ggaaggata  gtgttgctt  cagtagtta  1500
tgccaatat  gttgttggt  aatggcttg  agataaact  tctaataat  attatttct  1560
tgagtagct  agacttggt  ttgccaaaa  tcttggtaa  ttttgaaga  agactgtct  1620
atcaccaag  aaatttata  aaattaaga  taactttct  ggaattcac  attctggca  1680
taaattttg  tagactaat  cagtacagc  agacccaga  atttggaag  ctgtagatc  1740
gaggttcta  ttccctttc  ctcctttta  atcctcctc  ccttgagta  tgaagtgac  1800
agcctgtgt  gtgtgacaa  cgtgtctca  tcagcagga  aaactaatg  tatggatca  1860
cacccagat  ctctcactt  gtaccagca  ttctgtagg  attagagaa  agttctaag  1920
tttctaaac  ttaactgtt  cttaaggat  ttagccagt  ttttaatag  acatgatta  1980
tgaaagtga  aaattttaa  ttttctcta  tagtcctca  cataaactt  ttaaaggaa  2040
ataagcaaa  taaaaagaa  attggttta  ataaatact  atactttgc  aagtcaaaa  2100
tggcttgat  tttggaaac  atatagagg  attcatatt  aaatgaggg  ttacatttg  2160
tttgttttg  aaccgttaa  aagaagttg  ttccagcta  ttattgtgg  gtactatat  2220
tgtgagcct  gggtagggg  actgctgca  cttctgctt  catcccatg  ctcatcaat  2280
aggaaaggg  acaaagtgt  taaaacctg  cacaattgt  ttttaattt  gaggtatga  2340
attttcaga  atttcataa  ttctaacct  tgttctctc  gtaaacaga  tgtctgatc  2400
atcatgcag  tacaatgtt  gtatttgag  ggttagttt  tttcctaca  ttttttttg  2460
caactgact  aacaacatt  ctgtcaggt  gaaatttca  gcacttttg  acatttagt  2520
cagtgtttg  tgagaatcc  tggcttaac  cacttgttt  gctattttt  tctttgctt  2580
taattttcc  catctgatt  tatctctgc  tttcagtga  ctaccttaa  acaacacac  2640
agaagagtt  aactgggtt  attttaatg  tcaatttac  tgcatataa  atttatttt  2700
aatcaagct  atcttaatg  atataatca  tctatttgc  ttattatcg  tgcaggtag  2760
tcattaaca  cacttcttt  catctgtac  acaccctgg  gaaaccttt  aagacataa  2820
aaaaacctg  ctgagatgt  ctttctacc  atctatatg  ctttcggtt  tcaagtgtt  2880
ctgcatggt  atgtcatgt  aatgctgat  ttgatttca  tggtccatc  atatttaaa  2940
cgtgc  2945



<210> 1628
<211> 350
<212> PRT
<213> Homo sapiens
<308> P22694
<400> 1628

Gly Asn Ala Ala Thr Ala Lys Lys Gly Ser Glu Val Glu Ser Val Lys 
  1               5                  10                  15
Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu Asn 
             20                  25                  30
Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys Thr 
         35                  40                  45
Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys Ala 
     50                  55                  60
Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val Val 
 65                  70                  75                  80
Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu Gln 
                 85                  90                  95
Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr Ala Phe Lys Asp 
             100                105                110
Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu Met 
         115                120                125
Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala Arg 
     130                135                140
Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser Leu 
 145                150                155                160
Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp His 
                 165                170                175
Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val Lys 
             180                185                190
Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
         195                200                205
Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala Leu 
     210                215                220
Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe Ala 
 225                230                235                240
Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val Arg 
                 245                250                255
Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn Leu 
             260                265                270
Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly Val 
         275                280                285
Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp Trp Ile Ala 
     290                295                300
Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Arg Gly 
 305                310                315                320
Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Asp Ile Arg 
                 325                330                335
Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly Glu Phe 
             340                345                350



<210> 1629
<211> 2684
<212> DNA
<213> Rattus norvegicus
<308> D10852
<400> 1629

ggagacctg  ctagaagtt  cttagagag  ctgctctat  cttcacctt  gatgaagat  60
agacgctac  agctttttc  catgttctg  atggccggc  tgtgcctca  ctccttcct  120
cacttcttt  agacgttat  ctatgtcac  ttcccgaga  aactggcct  cctcagccc  180
aacctcata  ccagcttct  ctggaacaa  gcccctgtc  ctccccagg  cagtccgga  240
cccggtgac  ccgacttgt  acggactcc  ctctactcc  actcccccc  gctccagcc  300
ctgtcccct  gcaaggcca  cgaagaact  caccgggtg  acttcgtgt  gccggagga  360
accacagag  attttgtgc  caccaaagc  ggcggtgtg  gcttcaaac  aggtaccag  420
atgctggag  aaccttctc  agggcggac  gaggagaag  ccaaggtgg  tgaggggtc  480
tcggtccgg  gtcctgctc  gaggcctat  cggcatgtg  tgagtgcac  ggagcgcct  540
ggaggccgg  gcactaggc  caagtgggt  gagtgtgtg  gcctgccag  ctggcacgg  600
cccagctgc  gggtgccca  tgtggtcca  tattccaac  tgcccacca  ggagcgcct  660
gtacccagg  aggtgccga  gcgggttat  aacgccatc  acatcaacc  tgagttcga  720
ctgctggat  tgcgcttcc  tgagctggg  gatgttgtg  acgcctttg  ggtctgcga  780
tccaatttc  ccgcctacg  ggagcctcg  ccgctcaag  tccgagaga  gctgaccaa  840
ggcaccttc  agtacatcc  ccacaaggt  ctctacgtc  tcctggacc  cttcccacc  900
ggtggccgt  aggacggct  gattgcaga  gactacctg  gtaccttcc  cacccagga  960
ggtgtctcc  gcctgcgca  cctgcgacc  gatgacgtc  ttatcatcg  cgacgcgga  1020
gagatccct  cgcgtgatg  tgtgctgtt  ctcaagctc  acgatggct  gacagagcc  1080
ttcgccttc  atatgcgca  gtccctgta  ggtttcttt  ggaagcaac  aggcacact  1140
gaggtggtg  caggctgca  cattgacat  ctgcaggct  tgtatgggc  ggacggcat  1200
cgcctgcgc  gccgtcagt  ctacaccat  cccaacttt  gacagtatg  gaaccgcac  1260
ggccacatc  tagtgcagt  gtctctcgg  agccccctg  acttcgcgg  ctggcactg  1320
tcctggtgc  tcacacccg  gggcatcta  ttcaaactc  tgtcggccc  gaatggtga  1380
ttcccccgc  ggggtgact  cgaggacaa  agggacctc  attacatcc  aagcttgat  1440
cgcactggg  gatggttcg  cggcacgca  caggagtac  ctcctgcag  ccccagtga  1500
cacatgtat  ctcctaagt  cctgctcaa  aactatgac  agttccgct  cttgctcga  1560
aatccctac  gggagccca  gagcactgt  gagggtggg  gccggaacc  gggctcaga  1620
ggaaggtca  ctgctgtca  gggcaagtt  gatacaacg  agggctagg  ctgtgcagt  1680
tcacagggc  gggctggct  agatgatgg  taagccagt  ttatctttg  cctcctcat  1740
atcttgggg  tcttgagag  gccaggagt  cttggagtt  gtcctctgg  ctcaagccc  1800
ctagaatta  gggtcaggc  ttccatccc  aaacaggaa  gaaaaaaat  ttttttagt  1860
aagaagagc  agcccagat  tctatgcag  actttttgt  cccaagagt  ctgtgggaa  1920
gaggtgttc  tggggagca  gcagtcgtt  tctgggact  gtactggga  tgctatgga  1980
cttcagcct  gttaagaga  gcccacctt  gacatccca  attgttgtc  tgtaatgga  2040
aaggaggta  accatgcca  gagttccca  catcctgta  ataaatgca  tgggtccag  2100
agcaagaag  gacagtaag  agggactag  aagcgtatc  gctcccaat  ttggccaag  2160
ggctgggga  gcattggaa  atggcaccc  ggagagaga  cactttgca  cttcctcag  2220
catgctgga  ccaaggaat  aggtcacag  tggctggaa  ggtggagcc  gtggctgtc  2280
gtccctctg  ctctctaag  agacacgcc  ggggggctg  ggttccaaa  ataccttga  2340
gactgatca  tttcctgct  ctgtcttgt  ggagctgct  tgatggact  taggagtct  2400
gttctcggg  tgggacagg  gctggacac  atgtggaca  ccagtatag  aggtgggac  2460
agagaagga  acgaacaga  gccctatat  cttctctcc  tccccatca  tgtctgctg  2520
catccagtc  catttttac  acatcccct  ccccaggcc  gtaagagca  gctgggggc  2580
aggaaggga  tacaagttc  tccggggtc  aagaaagga  cttaaggtc  gtggcatta  2640
caacccatt  ctcttaatt  gtcttgggg  ggggggggg  gggg  2684



<210> 1630
<211> 536
<212> PRT
<213> Rattus norvegicus
<308> Q02527
<400> 1630

Met Arg Arg Tyr Lys Leu Phe Leu Met Phe Cys Met Ala Gly Leu Cys 
  1               5                  10                  15
Leu Ile Ser Phe Leu His Phe Phe Lys Thr Leu Ser Tyr Val Thr Phe 
             20                  25                  30
Pro Arg Glu Leu Ala Ser Leu Ser Pro Asn Leu Ile Ser Ser Phe Phe 
         35                  40                  45
Trp Asn Asn Ala Pro Val Thr Pro Gln Ala Ser Pro Glu Pro Gly Asp 
     50                  55                  60
Pro Asp Leu Leu Arg Thr Pro Leu Tyr Ser His Ser Pro Leu Leu Gln 
 65                  70                  75                  80
Pro Leu Ser Pro Ser Lys Ala Thr Glu Glu Leu His Arg Val Asp Phe 
                 85                  90                  95
Val Leu Pro Glu Asp Thr Thr Glu Tyr Phe Val Arg Thr Lys Ala Gly 
             100                105                110
Gly Val Cys Phe Lys Pro Gly Thr Arg Met Leu Glu Lys Pro Ser Pro 
         115                120                125
Gly Arg Thr Glu Glu Lys Thr Lys Val Ala Glu Gly Ser Ser Val Arg 
     130                135                140
Gly Pro Ala Arg Arg Pro Met Arg His Val Leu Ser Ala Arg Glu Arg 
 145                150                155                160
Leu Gly Gly Arg Gly Thr Arg Arg Lys Trp Val Glu Cys Val Cys Leu 
                 165                170                175
Pro Gly Trp His Gly Pro Ser Cys Gly Val Pro Thr Val Val Gln Tyr 
             180                185                190
Ser Asn Leu Pro Thr Lys Glu Arg Leu Val Pro Arg Glu Val Pro Arg 
         195                200                205
Arg Val Ile Asn Ala Ile Asn Ile Asn His Glu Phe Asp Leu Leu Asp 
     210                215                220
Val Arg Phe His Glu Leu Gly Asp Val Val Asp Ala Phe Val Val Cys 
 225                230                235                240
Glu Ser Asn Phe Thr Ala Tyr Gly Glu Pro Arg Pro Leu Lys Phe Arg 
                 245                250                255
Glu Met Leu Thr Asn Gly Thr Phe Glu Tyr Ile Arg His Lys Val Leu 
             260                265                270
Tyr Val Phe Leu Asp His Phe Pro Pro Gly Gly Arg Gln Asp Gly Trp 
         275                280                285
Ile Ala Asp Asp Tyr Leu Arg Thr Phe Leu Thr Gln Asp Gly Val Ser 
     290                295                300
Arg Leu Arg Asn Leu Arg Pro Asp Asp Val Phe Ile Ile Asp Asp Ala 
 305                310                315                320
Asp Glu Ile Pro Ala Arg Asp Gly Val Leu Phe Leu Lys Leu Tyr Asp 
                 325                330                335
Gly Trp Thr Glu Pro Phe Ala Phe His Met Arg Lys Ser Leu Tyr Gly 
             340                345                350
Phe Phe Trp Lys Gln Pro Gly Thr Leu Glu Val Val Ser Gly Cys Thr 
         355                360                365
Ile Asp Met Leu Gln Ala Val Tyr Gly Leu Asp Gly Ile Arg Leu Arg 
     370                375                380
Arg Arg Gln Tyr Tyr Thr Met Pro Asn Phe Arg Gln Tyr Glu Asn Arg 
 385                390                395                400
Thr Gly His Ile Leu Val Gln Trp Ser Leu Gly Ser Pro Leu His Phe 
                 405                410                415
Ala Gly Trp His Cys Ser Trp Cys Phe Thr Pro Glu Gly Ile Tyr Phe 
             420                425                430
Lys Leu Val Ser Ala Gln Asn Gly Asp Phe Pro Arg Trp Gly Asp Tyr 
         435                440                445
Glu Asp Lys Arg Asp Leu Asn Tyr Ile Arg Ser Leu Ile Arg Thr Gly 
     450                455                460
Gly Trp Phe Asp Gly Thr Gln Gln Glu Tyr Pro Pro Ala Asp Pro Ser 
 465                470                475                480
Glu His Met Tyr Ala Pro Lys Tyr Leu Leu Lys Asn Tyr Asp Gln Phe 
                 485                490                495
Arg Tyr Leu Leu Glu Asn Pro Tyr Arg Glu Pro Lys Ser Thr Val Glu 
             500                505                510
Gly Gly Arg Arg Asn Gln Gly Ser Asp Gly Arg Ser Ser Ala Val Arg 
         515                520                525
Gly Lys Leu Asp Thr Thr Glu Gly 
     530                535



<210> 1631
<211> 1744
<212> DNA
<213> Homo sapiens
<308> L48489
<400> 1631

gaattcctt  aacctggga  gcaggggct  cagtgagca  agatcgcac  actgcactt  60
agcctgggc  acagagcaa  actctatct  aaaaacaaa  aaacaaaca  aaacacaca  120
aaaaaattt  aattggaga  tgagaatat  caagcatct  cattccaca  ccataaact  180
attgataaa  taaactgta  aaatgaata  caaatggtt  catcatgag  catgaatac  240
gatgattta  tcacaatag  catgtaata  gtgggattt  aaaggaact  gtacattta  300
ttctactga  accaaaatc  tttaaatct  tcattgatt  aggaaaaca  cttggttag  360
cttagtgtc  aatatggta  tatttatga  aaatattaa  tcaagaata  aaaaattgc  420
tataaagcc  gagatagac  tcaaatttt  ttttttttt  tttagatgg  gtcttgctc  480
tgtcaccca  gttctggag  gcaatggcg  gatcatggc  cactgcaac  tccgccccc  540
gggttcaag  aattctcct  cctcagccg  tatagctgg  attataggc  tgcgccact  600
cactcagct  acttttgta  ttttagtag  gacagggtt  caccatgtt  gccaggctg  660
tctcgaact  ctgaccttg  gatctgccc  cctcggcct  ccaaagtgc  gggattata  720
gcgtgacga  tgcactggc  gacctcaaa  ttttatgtc  tggagatta  caaagggca  780
ggaataatg  aggggaact  ttattttat  ttgtttttg  gatagggtc  cagtctgtt  840
tccaggctg  ggcccagtg  tgcaatcat  gctcactgc  gcctcaacc  cgaggtctc  900
agtgatcct  ccacctcag  ctcctaagt  gctgggacc  caagcacat  gcaccacac  960
tggctaatt  ttaaatttt  tgtagagat  gggtctcac  atgttgtcc  agctggtct  1020
aaactcctg  gctcaagtg  tcctcctgc  tcagcctct  aaggtgttg  gattacagg  1080
gtgacgacc  ctcctggcc  aattttatt  attaaatat  ttagaatta  gtgtttttc  1140
ttgagacct  tgagttttt  cagtgaaaa  atattcaaa  ggtttgtca  tatgtccat  1200
aaaaagaag  taggagggg  gggacagga  ccaggaggg  agcctacag  ctgctctcc  1260
cgttctgtc  tggggcgga  tctgtactg  gagttgagc  tttcccaag  cgcatgtta  1320
tcctggagc  aagcctagc  gtgcagccg  acagtcagg  tggggtggg  caggcggag  1380
agcaggctg  agagggggc  gggtggtgg  ctggggatc  cagggaagg  ctatgggag  1440
acggcggtg  cctcagtac  ggggcttca  gggccttgg  accgcgagt  gactcttgg  1500
ggcaggagg  cactccatg  aggggcagc  ggtgctggc  accacattg  ccagcaagg  1560
ggcagcaga  gcctcctag  tcccttcct  ggaaaggag  ctgggctgc  ctgatgagt  1620
tcctgtctc  ctctctccc  caggatgaa  atgagacgc  acaagctct  tctcatgtt  1680
tgtatggcc  gcctgtgcc  catctcctt  ctgtacttc  tcaagaccc  gtcctatgt  1740
acct  1744



<210> 1632
<211> 531
<212> PRT
<213> Homo sapiens
<308> Q09327
<400> 1632

Met Arg Arg Tyr Lys Leu Phe Leu Met Phe Cys Met Ala Gly Leu Cys 
  1               5                  10                  15
Leu Ile Ser Phe Leu His Phe Phe Lys Thr Leu Ser Tyr Val Thr Phe 
             20                  25                  30
Pro Arg Glu Leu Ala Ser Leu Ser Pro Asn Leu Val Ser Ser Phe Phe 
         35                  40                  45
Trp Asn Asn Ala Pro Val Thr Pro Gln Ala Ser Pro Glu Pro Gly Gly 
     50                  55                  60
Pro Asp Leu Leu Arg Thr Pro Leu Tyr Ser His Ser Pro Leu Leu Gln 
 65                  70                  75                  80
Pro Leu Pro Pro Ser Lys Ala Ala Glu Glu Leu His Arg Val Asp Leu 
                 85                  90                  95
Val Leu Pro Glu Asp Thr Thr Glu Tyr Phe Val Arg Thr Lys Ala Gly 
             100                105                110
Gly Val Cys Phe Lys Pro Gly Thr Lys Met Leu Glu Arg Pro Pro Pro 
         115                120                125
Gly Arg Pro Glu Glu Lys Pro Glu Gly Ala Asn Gly Ser Ser Ala Arg 
     130                135                140
Arg Pro Pro Arg Tyr Leu Leu Ser Ala Arg Glu Arg Thr Gly Gly Arg 
 145                150                155                160
Gly Ala Arg Arg Lys Trp Val Glu Cys Val Cys Leu Pro Gly Trp His 
                 165                170                175
Gly Pro Ser Cys Gly Val Pro Thr Val Val Gln Tyr Ser Asn Leu Pro 
             180                185                190
Thr Lys Glu Arg Leu Val Pro Arg Glu Val Pro Arg Arg Val Ile Asn 
         195                200                205
Ala Ile Asn Val Asn His Glu Phe Asp Leu Leu Asp Val Arg Phe His 
     210                215                220
Glu Leu Gly Asp Val Val Asp Ala Phe Val Val Cys Glu Ser Asn Phe 
 225                230                235                240
Thr Ala Tyr Gly Glu Pro Arg Pro Leu Lys Phe Arg Glu Met Leu Thr 
                 245                250                255
Asn Gly Thr Phe Glu Tyr Ile Arg His Lys Val Leu Tyr Val Phe Leu 
             260                265                270
Asp His Phe Pro Pro Gly Gly Arg Gln Asp Gly Trp Ile Ala Asp Asp 
         275                280                285
Tyr Leu Arg Thr Phe Leu Thr Gln Asp Gly Val Ser Arg Leu Arg Asn 
     290                295                300
Leu Arg Pro Asp Asp Val Phe Ile Ile Asp Asp Ala Asp Glu Ile Pro 
 305                310                315                320
Ala Arg Asp Gly Val Leu Phe Leu Lys Leu Tyr Asp Gly Trp Thr Glu 
                 325                330                335
Pro Phe Ala Phe His Met Arg Thr Ser Leu Tyr Gly Phe Phe Trp Lys 
             340                345                350
Gln Pro Gly Thr Leu Glu Val Val Ser Gly Cys Thr Val Asp Met Leu 
         355                360                365
Gln Ala Val Tyr Gly Leu Asp Gly Ile Arg Leu Arg Arg Arg Gln Tyr 
     370                375                380
Tyr Thr Met Pro Asn Phe Arg Gln Tyr Glu Asn Arg Thr Gly His Ile 
 385                390                395                400
Leu Val Gln Trp Ser Leu Gly Ser Pro Leu His Phe Ala Gly Trp His 
                 405                410                415
Cys Ser Trp Cys Phe Thr Pro Glu Gly Ile Tyr Phe Lys Leu Val Ser 
             420                425                430
Ala Gln Asn Gly Asp Phe Pro Arg Trp Gly Asp Tyr Glu Asp Lys Arg 
         435                440                445
Asp Leu Asn Tyr Ile Arg Gly Leu Ile Arg Thr Gly Gly Trp Phe Asp 
     450                455                460
Gly Thr Gln Gln Glu Tyr Pro Pro Ala Asp Pro Ser Glu His Met Tyr 
 465                470                475                480
Ala Pro Lys Tyr Leu Leu Lys Asn Tyr Asp Arg Phe His Tyr Leu Leu 
                 485                490                495
Asp Asn Pro Tyr Gln Glu Pro Arg Ser Thr Ala Ala Gly Gly Trp Arg 
             500                505                510
His Arg Gly Pro Glu Gly Arg Pro Pro Ala Arg Gly Lys Leu Asp Glu 
         515                520                525
Ala Glu Val 
     530



<210> 1633
<211> 2469
<212> DNA
<213> Rattus norvegicus
<308> D12498
<400> 1633

atgtggggc  ggaggggcc  cctcttctg  gctgtgctg  tcacagcca  tctctgcac  60
gccagacca  ccccaacct  gcccgaaca  gctcagccc  ggggagtcc  tgtggaagt  120
gagtctctc  tggtccacc  tggtgacct  ctacagctt  gctgccggc  gcgcgatga  180
gtgcagagc  tcaactggc  gcgggatgg  gtgcagctg  cggaaagca  ccgtacacg  240
atcacaggg  aggaggtgg  ggtgcggga  tccatcccc  ctgactctg  cctctacgc  300
tgtgtgacc  acagcccct  tggcagcga  accacctac  tctccgtca  tgtctcaga  360
gcactgcca  cctcggagg  cgatgacga  gatgatgac  cctcctcag  ggagaaaga  420
acagacaac  ccaaaccaa  ccgtaggcc  gtggcgcca  actggacat  cccagagaa  480
atggagaag  aactgcacg  agtgccagc  gccaagacg  tgaaattca  atgcccgtc  540
agtgggaca  ccagcccca  tttgcgctg  ttgaaaaac  gcaaggaat  caaacctga  600
caccggatc  gaggctaca  ggttcgtta  gccacttgg  gcatcataa  ggactctgt  660
gtgccttct  acaagggca  ctacacctg  atcgtggag  acgagtatg  gagcattaa  720
cacacctac  agctagacg  tgtggagcg  tcccctcac  ggcccatcc  tcaggcagg  780
ctaccagcc  acaagaccg  ggccctggg  agcaacgtg  agttcatgt  caaggtgta  840
agtgacccc  agcctcaca  ccagtggct  aagcacatc  aggtgaatg  gagtaagat  900
ggtccagac  acttgccgt  tgaccagat  ctgaagact  ctggagtta  taccaccga  960
aaggaaatg  aggtgcttc  tctacggaa  gtctccttt  aggatgcgg  ggagtatac  1020
tgcttggcg  gtaactcta  cggactctc  catcactct  catggttga  cgttctgga  1080
gccctggaa  agagaccag  cgtgatgac  tcacctctg  acctggaaa  cattatcta  1140
tgcaccggg  ccttcctga  ctcctgtat  gtgggctcc  tcatcatct  caagatgaa  1200
agcggcacc  agaagagcg  cttccatag  cagatggct  tgcataagc  ggctaagag  1260
atccctctc  gcagacagg  aacagtgtc  gctgactcc  gcgcatcca  gaactccgg  1320
gttctcctg  ttcggcctt  gcgactgtc  tccagcgga  cccccatgc  agctggcgt  1380
tctgaatat  agctccctg  agatccccg  tgggagctg  cccgggaca  actggtctt  1440
ggaaaaccg  ttggcgagg  ctgcttcgg  caggtggtg  tggccgaag  catcggtct  1500
gataaggac  aacccaacc  cgtgaccaa  gtggccgtg  agatgttga  gtctgatgc  1560
acggagaag  acctgtcgg  cctgatctc  gagatggag  tgatgaaaa  gatcgggaa  1620
cacaagaat  tcatcaacc  gctgggggc  tgcacacag  atggtcctc  ctatgtcat  1680
gtggagtat  cctccaaag  caatcttcg  gagtatctg  aggcccgga  gcctcctgg  1740
ctggagtat  gctacaacc  cagccacaa  cctgaggaa  agctgtctt  caaagatct  1800
gtgtcctgt  cctatcagg  ggcccgggg  atggagtat  ttgcctcga  gaagtgtat  1860
caccgagac  tggctgcta  gaatgtcct  gtgacagag  ataatgtca  gaagatcgc  1920
gactttggc  tagctcgag  cattcacca  atcgactac  ataagaaaa  caccaatgg  1980
cggctgcct  tgaagtgga  ggcacctga  gcattgttt  accggatct  cacccacca  2040
agtgatgtg  ggtcttttg  ggtgctctt  tgggagata  tcactctgg  tggctcacc  2100
aaccccggc  tgcctgtgg  agaactttt  aagctgttg  aggagggtc  tcgaatgga  2160
aagcccagt  actgtacca  tgagctgta  atgatgatg  gggactgct  gaacgcagt  2220
ccctctcag  gaccaactt  caagcagtt  gtggaagac  tggaccgga  tgtggcctt  2280
acctccaac  aggagtatc  ggacctgtc  atgccactg  accaggact  gccaagctt  2340
ccggacaca  ggagctcta  ctgctcttc  ggggaggac  ctgtcttct  tcatgagcc  2400
tttcctgag  agccctgtc  gccccgaca  cccacccag  ttgcaaatg  cggactcaa  2460
cggcgctga  2469



<210> 1634
<211> 822
<212> PRT
<213> Rattus norvegicus
<308> Q04589
<400> 1634

Met Trp Gly Trp Arg Gly Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
  1               5                  10                  15
Thr Leu Cys Thr Ala Arg Pro Ala Pro Thr Leu Pro Glu Gln Ala Gln 
             20                  25                  30
Pro Trp Gly Val Pro Val Glu Val Glu Ser Leu Leu Val His Pro Gly 
         35                  40                  45
Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
     50                  55                  60
Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
 65                  70                  75                  80
Ile Thr Gly Glu Glu Val Glu Val Arg Asp Ser Ile Pro Ala Asp Ser 
                 85                  90                  95
Gly Leu Tyr Ala Cys Val Thr Asn Ser Pro Ser Gly Ser Asp Thr Thr 
             100                105                110
Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
         115                120                125
Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
     130                135                140
Lys Pro Asn Arg Arg Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
 145                150                155                160
Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                 165                170                175
Lys Cys Pro Ser Ser Gly Thr Pro Ser Pro Thr Leu Arg Trp Leu Lys 
             180                185                190
Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
         195                200                205
Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
     210                215                220
Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
 225                230                235                240
His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                 245                250                255
Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
             260                265                270
Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
         275                280                285
Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
     290                295                300
Leu Pro Tyr Asp Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
 305                310                315                320
Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                 325                330                335
Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
             340                345                350
Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
         355                360                365
Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
     370                375                380
Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Ile Tyr Lys Met Lys 
 385                390                395                400
Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                 405                410                415
Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
             420                425                430
Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
         435                440                445
Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
     450                455                460
Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
 465                470                475                480
Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                 485                490                495
Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
             500                505                510
Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
         515                520                525
Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
     530                535                540
Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
 545                550                555                560
Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                 565                570                575
Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
             580                585                590
Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
         595                600                605
Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
     610                615                620
Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
 625                630                635                640
Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                 645                650                655
Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
             660                665                670
Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
         675                680                685
Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Asn Pro Gly Val 
     690                695                700
Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
 705                710                715                720
Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                 725                730                735
Trp Asn Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
             740                745                750
Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
         755                760                765
Leu Ser Met Pro Leu Asp Gln Asp Ser Pro Ser Phe Pro Asp Thr Arg 
     770                775                780
Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
 785                790                795                800
Phe Pro Glu Glu Pro Cys Leu Pro Arg His Pro Thr Gln Leu Ala Asn 
                 805                810                815
Gly Gly Leu Asn Arg Arg 
             820



<210> 1635
<211> 3816
<212> DNA
<213> Rattus norvegicus
<308> D12524
<400> 1635

gctgtagca  agagaggag  tcagagtct  gcgcagcca  cgcgatgag  ggcgctcgc  60
gcgcctggg  tctgctctg  gtcctgttg  tcctgctcc  tggccagac  gggacttct  120
agccatctg  gagtccagg  gagccgtct  caccatcca  ccagccggc  cagtcagag  180
taatagttg  agccgggga  accatcagg  tgacgtgca  tgaccccgc  tttgtcaaa  240
ggactttcg  gatcctcga  gtaaggatt  agaataagc  gagcgaatg  attcgagaa  300
aagccgagg  cactcacac  ggcaaatac  cgtgcgtca  cggcagcgg  ctcaggagc  360
ctatttacg  gttcgttag  gatcctgcc  tacttttcc  ggttggcct  cccttgttt  420
gcaaagaag  caacgacgc  ctggtccgc  gccccctga  agacccaca  gtgtccaat  480
actccctca  tgagtgtga  gggaaatct  tccccacgg  cctgaagtt  gtccccaac  540
ccaaggctg  catcaccat  aaaaacgtg  agcgcgcct  ccaccggct  tgcatccgg  600
gtgctgccc  gcgtgaggg  aaatggatg  ggtctgaca  attcaccct  aaagtgaga  660
cagccatca  agctatccc  gtggtgtct  tgcccgaaa  aagtcatct  cttaaggaa  720
gggacacat  tacggtgat  tgcaccata  aagacgtgt  tacatccgt  gactccatg  780
ggataaagt  gaaccctca  cctcagagc  aagcccagg  aaagcgcaa  agctggcat  840
agggcgact  caattacga  cgccaggag  cgctgacta  cagctcagc  agagttaac  900
attccggag  gttcatgtg  tatgccaat  atacttttg  atcagcaaa  gtcacaaca  960
ccttgaaag  agtagaaaa  ggattcatc  acatcttcc  tgtgaagaa  actacggta  1020
ttgtaactg  tggggaaaa  gtagacttg  ttgttgagt  cgaggccta  cctaaacct  1080
aacaccagc  gtggatcta  atgaacagg  cgcctacta  cagagggga  gattatgtc  1140
aatccgaca  ccaaagcaa  atcagatat  tgaacgaac  tcgcctgac  agattgaaa  1200
gcacagaag  aggcactta  acctttctg  tgtccaact  tgatgtcag  gcttccgtg  1260
catttgatg  ttatgtgaa  acaaaacca  aaatcctga  atatgacag  ctcatgaat  1320
gcaggctcc  gtgtgtggc  gcgggattc  cggagccca  aatagattg  tatttttgt  1380
caggggcag  gcaaaggtg  accgttcct  tcccgccag  agacgtaca  atccagaat  1440
cgtctgtgt  accatttgg  aaactggtg  ttcagagtt  catagactc  agcgtcttc  1500
ggcacaacg  cacggtgga  tgtaaggcc  ccaacgctg  gggcaagag  tctgccttc  1560
ttaactttg  atttaaagg  aacagcaaa  agcaaatcc  gccccacac  ctgttcacg  1620
cgctgctca  tggcttcgt  gtcacagcc  gcttgatgg  gatcattgt  atggttctt  1680
cctacaaat  tttgcagaa  cccatgtat  aagtacaat  gaaggttgt  gaggagata  1740
atgggaaca  ttatgttta  atagaccca  cgcagcttc  ttatgacca  aaatgggag  1800
ttcccagaa  caggctgag  tttggaaag  ccttgggag  tggtgcctt  gggaaggta  1860
ttgaggcca  tgcctatgg  ttaattaag  cggatgccg  catgacggt  gccgtgaag  1920
tgctcaaac  aagtgccca  ttaacggaa  gggaggccc  aatgtcaga  ctgaaggtc  1980
tgagctacc  gggtaatca  atgaatatc  tcaacctcc  tggagcgtg  accgtggga  2040
ggcccaccc  ggtcattac  gaatactgt  gctatggtg  tcttttgaa  ttcttgaga  2100
gaaagcgtg  ctcgtttat  ttctcaaag  aagaagaac  ggcagacgc  gcactttat  2160
agaaccttc  gcattcaaa  gagtcttcc  gtgacagct  aaacgagta  atggacatg  2220
agcctggcg  ttcctacgt  gtaccaacc  agacagaca  aaggagatc  gcaagaata  2280
actcgtata  agaaagaga  gtgactccc  ccatcatgg  agatgacga  ctggctctg  2340
acctggaag  tttgctgag  ttttcctac  aggtggcca  gggcatggc  ttcctcgcc  2400
ccaagaact  tattcacag  gatttggca  ccaggaata  cctcctcac  cacgggcgg  2460
tcacaaaga  ttgcgattt  ggcctagcc  gagacatca  gaatgattc  aattacgtg  2520
taaaaggaa  tgcacggct  cccgtgaag  ggatggcac  ggagagcat  ttcaactgc  2580
tgtacacat  tgaaagtga  gtctggtcc  atgggattt  cctctggga  ctattctct  2640
taggaagca  cccctaccc  gggatgccg  tcgattcca  gttttacaa  atgatcaag  2700
aaggtttcc  aatgctcag  cctgagcac  cgcctgccg  aatgtatga  gttatgaag  2760
cttgctggg  tgctgatcc  ctgaaaagg  caacattca  gcaggttgt  cagctcatt  2820
agaagcaga  ctcagacag  agcaaacat  tttactcca  cttagcaaa  tgtaacccc  2880
acccagaga  ccccgtggt  gtggaccat  ctgtgaggg  caattccgt  ggcagcagc  2940
cctcttcca  acagcctct  ctcgtgcat  aggacgcct  agtagaaac  gagcccgat  3000
ggcattgct  tggtctcca  ccccattct  ctggcttct  tgatggtta  tttgttttc  3060
tttgacttg  atcctactc  agggtagcg  gatccccgc  ccaccccca  ccccactgt  3120
attctgcct  ttatgagca  actttagtg  ctgatggcc  ttccttttc  ccatcagcc  3180
ccatcccac  aagaaggtc  gaacggtat  tatatattt  cccattagc  aagtagccc  3240
tactgtaaa  ggaaggcct  atgctttag  ggaggaagg  tagggtgca  cggggatgc  3300
tggagttct  cacagtgct  ctccgagtg  gtttgaaaa  tatggccag  agttcattt  3360
aagagttta  aagtagtcc  gttttggcc  agagagcct  ccataatga  gggcagatg  3420
atgtagcaa  actagaaag  aaacccaag  cctgtgtgt  gaaagtaga  cattattag  3480
acagaggac  catgagaac  tctaggcct  agaagtctg  tcatgctga  aacgagacc  3540
aggctgaga  ggcgcaagc  ctggaagcg  ggacataga  gctctgttc  ggggctgcg  3600
gggcttttg  gcaagcttt  gtacaactg  cctggtttt  aaatagtct  ctgttgggg  3660
gtagaattg  agacaaggc  tcctcccta  ccagcgttt  tatatactc  ctgtacgtt  3720
tatgcgttc  tactttgga  cgggggatc  ccccacaag  tttagtttc  gtgtacaac  3780
ctgggatta  gtctgctgt  tgtaagaat  gattta  3816



<210> 1636
<211> 978
<212> PRT
<213> Rattus norvegicus
<308> BAA02094
<400> 1636

Met Arg Gly Ala Arg Gly Ala Trp Asp Leu Leu Cys Val Leu Leu Val 
  1               5                  10                  15
Leu Leu Arg Gly Gln Thr Gly Thr Ser Gln Pro Ser Ala Ser Pro Gly 
             20                  25                  30
Glu Pro Ser Pro Pro Ser Ile Gln Pro Ala Gln Ser Glu Leu Ile Val 
         35                  40                  45
Glu Ala Gly Asp Thr Ile Arg Leu Thr Cys Thr Asp Pro Ala Phe Val 
     50                  55                  60
Lys Trp Thr Phe Glu Ile Leu Asp Val Arg Ile Glu Asn Lys Gln Ser 
 65                  70                  75                  80
Glu Trp Ile Arg Glu Lys Ala Glu Ala Thr His Thr Gly Lys Tyr Thr 
                 85                  90                  95
Cys Val Ser Gly Ser Gly Leu Arg Ser Ser Ile Tyr Val Phe Val Arg 
             100                105                110
Asp Pro Ala Val Leu Phe Leu Val Gly Leu Pro Leu Phe Gly Lys Glu 
         115                120                125
Asp Asn Asp Ala Leu Val Arg Cys Pro Leu Thr Asp Pro Gln Val Ser 
     130                135                140
Asn Tyr Ser Leu Ile Glu Cys Asp Gly Lys Ser Leu Pro Thr Asp Leu 
 145                150                155                160
Lys Phe Val Pro Asn Pro Lys Ala Gly Ile Thr Ile Lys Asn Val Lys 
                 165                170                175
Arg Ala Tyr His Arg Leu Cys Ile Arg Cys Ala Ala Gln Arg Glu Gly 
             180                185                190
Lys Trp Met Arg Ser Asp Lys Phe Thr Leu Lys Val Arg Ala Ala Ile 
         195                200                205
Lys Ala Ile Pro Val Val Ser Val Pro Glu Thr Ser His Leu Leu Lys 
     210                215                220
Glu Gly Asp Thr Phe Thr Val Ile Cys Thr Ile Lys Asp Val Ser Thr 
 225                230                235                240
Ser Val Asp Ser Met Trp Ile Lys Leu Asn Pro Gln Pro Gln Ser Lys 
                 245                250                255
Ala Gln Val Lys Arg Asn Ser Trp His Gln Gly Asp Phe Asn Tyr Glu 
             260                265                270
Arg Gln Glu Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly 
         275                280                285
Val Phe Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr 
     290                295                300
Thr Thr Leu Lys Val Val Glu Lys Gly Phe Ile Asn Ile Phe Pro Val 
 305                310                315                320
Lys Asn Thr Thr Val Phe Val Thr Asp Gly Glu Asn Val Asp Leu Val 
                 325                330                335
Val Glu Phe Glu Ala Tyr Pro Lys Pro Glu His Gln Gln Trp Ile Tyr 
             340                345                350
Met Asn Arg Thr Pro Thr Asn Arg Gly Glu Asp Tyr Val Lys Ser Asp 
         355                360                365
Asn Gln Ser Asn Ile Arg Tyr Val Asn Glu Leu Arg Leu Thr Arg Leu 
     370                375                380
Lys Gly Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp 
 385                390                395                400
Val Ser Ala Ser Val Thr Phe Asp Val Tyr Val Asn Thr Lys Pro Glu 
                 405                410                415
Ile Leu Thr Tyr Asp Arg Leu Met Asn Gly Arg Leu Gln Cys Val Ala 
             420                425                430
Ala Gly Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Thr Gly Ala 
         435                440                445
Glu Gln Arg Cys Thr Val Pro Val Pro Pro Val Asp Val Gln Ile Gln 
     450                455                460
Asn Ala Ser Val Ser Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile 
 465                470                475                480
Asp Ser Ser Val Phe Arg His Asn Gly Thr Val Glu Cys Lys Ala Ser 
                 485                490                495
Asn Ala Val Gly Lys Ser Ser Ala Phe Phe Asn Phe Ala Phe Lys Gly 
             500                505                510
Asn Ser Lys Glu Gln Ile Gln Pro His Thr Leu Phe Thr Pro Leu Leu 
         515                520                525
Ile Gly Phe Val Val Thr Ala Gly Leu Met Gly Ile Ile Val Met Val 
     530                535                540
Leu Ala Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys 
 545                550                555                560
Val Val Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr 
                 565                570                575
Gln Leu Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser 
             580                585                590
Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala 
         595                600                605
Thr Ala Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val 
     610                615                620
Lys Met Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met 
 625                630                635                640
Ser Glu Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val 
                 645                650                655
Asn Leu Leu Gly Ala Cys Thr Val Gly Gly Pro Thr Leu Val Ile Thr 
             660                665                670
Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg 
         675                680                685
Asp Ser Phe Ile Phe Ser Lys Gln Glu Glu Gln Ala Asp Ala Ala Leu 
     690                695                700
Tyr Lys Asn Leu Leu His Ser Lys Glu Ser Ser Cys Asp Ser Ser Asn 
 705                710                715                720
Glu Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys 
                 725                730                735
Thr Asp Lys Arg Arg Ser Ala Arg Ile Asp Ser Tyr Ile Glu Arg Asp 
             740                745                750
Val Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu 
         755                760                765
Asp Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu 
     770                775                780
Ala Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu 
 785                790                795                800
Leu Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg 
                 805                810                815
Asp Ile Arg Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu 
             820                825                830
Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr 
         835                840                845
Phe Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe 
     850                855                860
Ser Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe 
 865                870                875                880
Tyr Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala 
                 885                890                895
Pro Ala Ala Met Tyr Glu Val Met Lys Thr Cys Trp Asp Ala Asp Pro 
             900                905                910
Leu Lys Arg Pro Thr Phe Lys Gln Val Val Gln Leu Ile Glu Lys Gln 
         915                920                925
Ile Ser Asp Ser Ser Lys His Ile Tyr Ser Asn Leu Ala Asn Cys Asn 
     930                935                940
Pro Asn Pro Glu Asn Pro Val Val Val Asp His Ser Val Arg Val Asn 
 945                950                955                960
Ser Val Gly Ser Ser Thr Ser Ser Thr Gln Pro Leu Leu Val His Glu 
                 965                970                975
Asp Ala 
             980



<210> 1637
<211> 5084
<212> DNA
<213> Homo sapiens
<308> NM_000222
<400> 1637

gatcccatc  cagctaccg  gatgagagg  gctcgcggc  cctgggatt  tctctgcgt  60
ctgctccta  tgcttcgcg  ccagacagg  tcttctcaa  catctgtga  tccagggga  120
ccgtctcca  catccatcc  tccaggaaa  tcagactta  tagtccgcg  gggcgacga  180
attaggctg  tatgcactg  tccgggctt  gtcaaatgg  cttttgaga  cctggatga  240
acgaatgag  ataagcaga  tgaatggat  acggaaaag  cagaagcca  caacaccgg  300
aaatacacg  gcaccaaca  acacggctt  agcaattcc  tttatgtgt  tgttagaga  360
cctgccaag  ttttccttg  tgaccgctc  ttgtatggg  aagaagaca  cgacacgct  420
gtccgctgt  ctctcacag  cccagaagt  accaattat  ccctcaagg  gtgccaggg  480
aagcctctt  ccaaggact  gaggtttat  cctgacccc  aggcgggca  catgatcaa  540
agtgtgaaa  gcgcctacc  tcggctctg  ctgcattgt  ctgtggacc  ggagggcaa  600
tcagtgctg  cggaaaaat  catcctgaa  gtgaggcca  ccttcaaag  tgtgcctgt  660
gtgtctgtg  ccaaagcaa  ctatcttct  agggaaggg  aagaattca  agtgacgtg  720
acaataaaa  atgtgtcta  ttctgtgta  tcaacgtgg  aaagagaaa  cagtcagac  780
aaactacag  agaaatata  tagctggca  cacggtgac  tcaattatg  acgtcaggc  840
acgttgact  tcagttcag  gagagttaa  gattctgga  tgttcatgt  ttatgccaa  900
aatactttt  gatcagcaa  tgtcacaac  accttggaa  tagtagata  aggattcat  960
aatatcttc  ccatgataa  cactacagt  tttgtaaac  atggagaaa  tgtagattt  1020
attgttgaa  atgaagcat  ccccaaacc  gaacaccag  agtggatct  tatgaacag  1080
accttcact  ataaatggg  agattatcc  aagtctgag  atgaaagta  tatcagata  1140
gtaagtgaa  ttcatctaa  gagattaaa  ggcaccgaa  gaggcactt  cacattcct  1200
gtgtccaat  ctgacgtca  tgctgccat  gcatttaat  tttatgtga  tacaaaacc  1260
gaaatcctg  cttacgaca  gctcgtgaa  ggcatgctc  aatgtgtgg  agcaggatt  1320
ccagagccc  caatagatt  gtatttttg  ccaggaact  agcagagat  ctctgcttc  1380
gtactgcca  tggatgtgc  gacactaaa  tcatctggg  caccgtttg  aaagctagt  1440
gttcagagt  ctatagatt  tagtgcatt  aagcacaat  gcacggttg  atgtaaggc  1500
tacaacgat  tgggcaaga  ttctgccta  tttaacttt  catttaaag  taacaacaa  1560
gagcaaatc  atccccaca  cctgttcac  cctttgctg  ttggtttcg  aatcgtagc  1620
ggcatgatg  gcattattg  gatgattct  acctacaaa  atttacaga  acccatgta  1680
gaagtacag  ggaaggttg  tgaggagat  aatggaaac  attatgttt  catagaccc  1740
acacaactt  cttatgatc  caaatggga  tttcccaga  acaggctga  ttttgggaa  1800
accctgggt  ctggagctt  cgggaaggt  gttgaggca  ctgcttatg  cttaattaa  1860
tcagatgcg  ccatgactg  cgctgtaaa  atgctcaag  cgagtgccc  tttgacaga  1920
cgggaagcc  tcatgtctg  actcaaagt  ctgagttac  ttggtaatc  catgaatat  1980
gtgaatcta  ttggagcct  caccattgg  gggcccacc  tggtcatta  agaatattg  2040
tgctatggt  atcttttga  ttttttgag  agaaaacgt  attcattta  ttgttcaaa  2100
caggaagat  atgcagaag  tgcacttta  aagaatctt  tgcattcaa  ggagtcttc  2160
tgcagcgat  gtactaatg  gtacatgga  atgaaacct  gagtttctt  tgttgtccc  2220
accaaggcc  acaaaagga  atctgtgag  ataggctca  acatagaaa  agatgtgac  2280
cccgccatc  tggaggatg  cgagttggc  ctagactta  aagacttgc  gagcttttc  2340
taccaggtg  caaagggca  ggctttcct  gcctccaag  attgtattc  cagagactt  2400
gcagccaga  atatcctcc  tactcatgg  cggatcaca  agatttgtg  ttttggtct  2460
gccagagac  tcaagaatg  ttctaatta  gtggttaaa  gaaacgctc  actacctgt  2520
aagtggatg  cacctgaaa  cattttcaa  tgtgtatac  cgtttgaaa  tgacgtctg  2580
tcctatggg  tttttcttt  ggagctgtt  tctttagga  gcagcccct  tcctggaat  2640
ccggtcgat  ctaagttct  caagatgat  aaggaaggc  tccggatgc  cagccctga  2700
cacgcacct  ctgaaatgt  tgacataat  aagacttgc  gggatgcag  tcccctaaa  2760
agaccaaca  tcaagcaaa  tgttcagct  attgagaag  agatttcag  gagcaccaa  2820
catatttac  ccaacttag  aaactgcag  cccaaccga  agaagcccg  ggtagacca  2880
tctgtgcgg  tcaattctg  cggcagcac  gcttcctcc  cccagcctc  gcttgtgca  2940
gacgatgtc  gagcagaat  agtgtttgg  tcacccctc  aggaatgat  tcttctttt  3000
gcttccatg  tggttattt  cttttcttt  aacttgcat  caactccag  atagtgggc  3060
ccccactgc  atcctgtct  tctgagcac  ctttagtgg  cgatgattt  tgtcatcag  3120
caccatcct  ttgcaaagg  tccaactgt  tatattccc  atagcaacg  agcttctac  3180
atgaacaga  aacattctg  tttggaaaa  gagagggag  tatggactg  gggccagag  3240
cctttccaa  gcttctcca  ttctgccca  aaatatggt  gatagttta  ctgaataaa  3300
ggtagtaat  acagttggc  ttcagaacc  tccatagta  tatgatgat  caagattag  3360
agctgaaaa  ctaagtcct  tatgtggaa  acagaacat  attagaaca  aggacagag  3420
atgaacacc  gggcttaag  aatctagta  ttcatgctg  gaatgagac  taggccatg  3480
aaaaaatga  ccccaagtg  gaacaaaag  tgctcttct  tggaccact  catgagctt  3540
tatactacc  acctggttt  taaatagag  ttgctatta  agcattgaa  tggagagaa  3600
gcctcccta  ccagcactt  tatatacgc  tctataaat  gtccgtgtt  atacatttg  3660
ggggaaaac  ccataaggt  tcgtttctg  atacaaccc  ggcattatg  ccactgtgt  3720
tagaagtag  ttaagagcc  tataagttt  aaggaaaca  ttaatacca  tttttaagg  3780
aacaatata  ccacaaagc  cagtttgaa  aaaatctcc  cttttagct  atgaactta  3840
tctgtagat  ctgtggaac  agcctatca  cttcagaat  gcattgtac  caatggatt  3900
gatgctgtt  gacaaagtt  ctgattcac  gcatggctc  cacaggagt  ggaaaacac  3960
gccatctta  tttggattc  tatgtagca  gaaataaag  ataggttta  cctccttcg  4020
aggcatgtc  tggacaccg  gccagtatc  atatatgtg  atgtacgtt  gtatgtgtg  4080
agacaaata  ttggagggg  atttttgcc  tgagtccaa  agggtcctt  agtacctga  4140
aagtaactt  gctttcatt  ttagtactg  tcttgtttc  tttcacata  ctgtctaga  4200
tagcttacc  gaagcttcc  tagtggtgc  gaggaagtg  aaggcatca  tccctatgt  4260
tttgcagtt  acctgcact  aaggcactc  gttatttag  ctcatctta  tgtacctgt  4320
ccttagacc  tccataatg  tactgtctc  ctgaaacat  taaatttta  cctttagac  4380
gtagcctgg  tattattct  gtagtttac  tctttaaaa  caaaacaaa  caaaacaaa  4440
aactcccct  cctcactgc  caatataaa  ggcaaatgt  tacatggca  agtttgtgt  4500
ttgtcttga  agattcagg  atgttgcct  tatggtttc  cccttctac  tttcttaga  4560
tacatttag  gaactgtgg  cgttatctg  aagtaacca  ttgcactgg  gttctatgc  4620
ctcgcacct  tccaaagtt  acagatttt  gggttgtgt  gtcacccaa  agattgttg  4680
ttgccatac  ttgtctgaa  aattccttt  tgtttctat  gacttcaat  atagtaaga  4740
aagtggttg  tagttatag  tgtctaggt  cttcagggg  acttcattg  gagttttgt  4800
ttgccatac  ttgtctgaa  aattccttt  tgtttctat  gacttcaat  atagtaaga  4860
aagtggttg  tagttatag  tgtctaggt  cttcagggg  acttcattg  gagttttgt  4920
aatgtcttt  gaatattcc  aagcccatg  gtccttgaa  atatttttt  tatatacag  4980
aactttatg  gtaaataca  aagcggcgt  agtttaaag  atgttggtg  tccacgtgt  5040
ttattcctg  atgttgtcc  attgttgac  gttctgaag  attc  5084



<210> 1638
<211> 976
<212> PRT
<213> Homo sapiens
<308> P10721
<400> 1638

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
  1               5                  10                  15
Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
             20                  25                  30
Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
         35                  40                  45
Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
     50                  55                  60
Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
 65                  70                  75                  80
Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                 85                  90                  95
Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
             100                105                110
Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
         115                120                125
Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
     130                135                140
Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
 145                150                155                160
Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                 165                170                175
Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
             180                185                190
Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
         195                200                205
Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
     210                215                220
Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
 225                230                235                240
Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                 245                250                255
Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
             260                265                270
Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
         275                280                285
Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
     290                295                300
Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
 305                310                315                320
Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                 325                330                335
Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
             340                345                350
Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
         355                360                365
Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
     370                375                380
Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
 385                390                395                400
Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                 405                410                415
Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
             420                425                430
Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
         435                440                445
Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
     450                455                460
Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
 465                470                475                480
Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                 485                490                495
Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
             500                505                510
Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
         515                520                525
Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
     530                535                540
Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
 545                550                555                560
Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                 565                570                575
Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
             580                585                590
Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
         595                600                605
Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
     610                615                620
Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
 625                630                635                640
Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                 645                650                655
Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
             660                665                670
Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
         675                680                685
Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
     690                695                700
Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
 705                710                715                720
Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                 725                730                735
Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
             740                745                750
Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
         755                760                765
Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
     770                775                780
Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
 785                790                795                800
Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                 805                810                815
Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
             820                825                830
Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
         835                840                845
Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
     850                855                860
Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
 865                870                875                880
Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                 885                890                895
Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
             900                905                910
Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
         915                920                925
Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
     930                935                940
Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
 945                950                955                960
Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                 965                970                975



<210> 1639
<211> 1561
<212> DNA
<213> Rattus norvegicus
<308> D12573
<400> 1639

gagtgtgtg  tctggggcc  cctctctct  tttgggtca  atgagagtt  ggggtatct  60
gtgtctgag  gcccttctg  agtagtgtc  agggactaa  aggatgtaa  cattgctct  120
tcctttcac  tcctttggt  ggggggaac  caggtggga  ttggctctt  tgccatggg  180
aagcagaat  gcaagctgc  gccagagat  ctgcaggac  tgcgagaga  caccgagtt  240
tctgagctg  agcttcagg  gtggtacaa  ggcttcctg  aggactgcc  gactggcat  300
ctcaacgtg  atgagttca  gaagatcta  gccaacttc  tcccctacg  cgatgcctc  360
aagttcgcc  agcatgtct  ccgcacttt  gacaccaac  gcgacggca  catcgactt  420
cgggagttc  tcatcgctc  gagcgtgac  tcgcgtggc  gcctggagc  gaagctcat  480
tgggccttc  gcatgtacg  cctggacgg  aatggctac  tcagccggg  ggagatgct  540
gaaattgtg  aggccattt  caagatggt  tcgtccgtg  tgaagatgc  tgaggatga  600
tctaccccg  aaaagagga  tgagaaaat  ttccgccaa  tggacacaa  caatgacgg  660
aagctgtca  tggaggagt  catccgcgg  gccaaaagc  acccatcga  cgtgcgcct  720
ctgcaatgc  atcccagca  cgcttccca  ttctgagct  agaggagcc  gctcgcctc  780
ctgccttca  cggccctcc  gctctcagc  tcctctccc  cgtgtctat  caggctggg  840
aatcccctt  tgggtctgc  ctgtggggg  gcctctgga  aagcgaacc  tgcaaggaa  900
gggctaagc  aggcagccg  tagtcccca  ggcctaaga  gcagaatct  ccttagtgg  960
ccgagatta  ccccgggtc  ggttctgta  ctttcccca  acagctgat  accttccac  1020
ccacccaca  cccgaggct  ttccacaac  cgggaagag  ggctaggtc  ttcttgggt  1080
gtcctcagc  tggagggag  tggggattt  tgccaaggt  aagagtctt  ttgtttgtt  1140
tggtgggga  gaccggagg  ttactgggc  gtgggactt  gaagaagtt  cctgatcta  1200
ttccctgca  aagaacact  cctgtccca  ctcttgctg  tggaggcat  gtaaaaaga  1260
gatctccca  gattccaac  gggggtccc  aaacccagc  tgcctcttt  cacttggat  1320
acacagatt  acccgtctg  cctctgtat  tctctctcc  tccccacct  acacacgca  1380
ggggccgcg  gacatgcgc  cgcaacaca  acacacaca  acacgcacg  tatgcacgc  1440
cacatgcac  gcacccgcg  acacagagg  cggcagaca  atgagcaga  cccctccac  1500
gcgttctgt  tgggaaaga  gtgcagccc  tgccaagcc  catgtccct  tgcatgcgc  1560
g  1561



<210> 1640
<211> 192
<212> PRT
<213> Rattus norvegicus
<308> P32076
<400> 1640

Gly Lys Gln Asn Ser Lys Leu Arg Pro Glu Met Leu Gln Asp Leu Arg 
  1               5                  10                  15
Glu Asn Thr Glu Phe Ser Glu Leu Glu Leu Gln Glu Trp Tyr Lys Gly 
             20                  25                  30
Phe Leu Lys Asp Cys Pro Thr Gly Ile Leu Asn Val Asp Glu Phe Lys 
         35                  40                  45
Lys Ile Tyr Ala Asn Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe Ala 
     50                  55                  60
Glu His Val Phe Arg Thr Phe Asp Thr Asn Ser Asp Gly Thr Ile Asp 
 65                  70                  75                  80
Phe Arg Glu Phe Ile Ile Ala Leu Ser Val Thr Ser Arg Gly Arg Leu 
                 85                  90                  95
Glu Gln Lys Leu Met Trp Ala Phe Ser Met Tyr Asp Leu Asp Gly Asn 
             100                105                110
Gly Tyr Ile Ser Arg Glu Glu Met Leu Glu Ile Val Gln Ala Ile Tyr 
         115                120                125
Lys Met Val Ser Ser Val Met Lys Met Pro Glu Asp Glu Ser Thr Pro 
     130                135                140
Glu Lys Arg Thr Glu Lys Ile Phe Arg Gln Met Asp Thr Asn Asn Asp 
 145                150                155                160
Gly Lys Leu Ser Leu Glu Glu Phe Ile Arg Gly Ala Lys Ser Asp Pro 
                 165                170                175
Ser Ile Val Arg Leu Leu Gln Cys Asp Pro Ser Ser Ala Ser Gln Phe 
             180                185                190



<210> 1642
<211> 192
<212> PRT
<213> Homo sapiens
<308> P32076
<400> 1642

Gly Lys Gln Asn Ser Lys Leu Arg Pro Glu Met Leu Gln Asp Leu Arg 
  1               5                  10                  15
Glu Asn Thr Glu Phe Ser Glu Leu Glu Leu Gln Glu Trp Tyr Lys Gly 
             20                  25                  30
Phe Leu Lys Asp Cys Pro Thr Gly Ile Leu Asn Val Asp Glu Phe Lys 
         35                  40                  45
Lys Ile Tyr Ala Asn Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe Ala 
     50                  55                  60
Glu His Val Phe Arg Thr Phe Asp Thr Asn Ser Asp Gly Thr Ile Asp 
 65                  70                  75                  80
Phe Arg Glu Phe Ile Ile Ala Leu Ser Val Thr Ser Arg Gly Arg Leu 
                 85                  90                  95
Glu Gln Lys Leu Met Trp Ala Phe Ser Met Tyr Asp Leu Asp Gly Asn 
             100                105                110
Gly Tyr Ile Ser Arg Glu Glu Met Leu Glu Ile Val Gln Ala Ile Tyr 
         115                120                125
Lys Met Val Ser Ser Val Met Lys Met Pro Glu Asp Glu Ser Thr Pro 
     130                135                140
Glu Lys Arg Thr Glu Lys Ile Phe Arg Gln Met Asp Thr Asn Asn Asp 
 145                150                155                160
Gly Lys Leu Ser Leu Glu Glu Phe Ile Arg Gly Ala Lys Ser Asp Pro 
                 165                170                175
Ser Ile Val Arg Leu Leu Gln Cys Asp Pro Ser Ser Ala Ser Gln Phe 
             180                185                190



<210> 1643
<211> 2721
<212> DNA
<213> Rattus norvegicus
<308> D12769
<400> 1643

gcggccgtc  gcggacgcg  gaagaagtg  cttgtaggc  cggcgcccc  ctcagcccc  60
gcccccctc  tccgcgtac  cggctgatg  ctcagggcg  cagctcggc  gagaggcgg  120
cgaggcgtg  gcctggcta  cagttggct  tccccgtga  tcggacacg  ttgcagtcg  180
ataaacttg  gaccgccac  tgtggcatc  ctccaagga  ccggctcag  aggagggcg  240
gcccatcgt  ggatcgcgc  gggcgcccg  cagggcggc  gcgacagcg  cagagccgg  300
cgcggctgc  gcgtgcgga  gcgctgccg  ttacgtaaa  atgaggggc  gaggtcgcc  360
cggcgctcc  gcgagtcgc  agctcccgc  cccccgccc  ctcggccgc  ccgcaccgc  420
ctcgtcgtc  gagaccagg  cagggctag  cgaagctcc  cagccaccc  caagtttgg  480
cgcaccgcc  gggctgccg  cgcccgcac  atgtccgcg  ccgcctaca  ggacttcgt  540
gctgcccag  gtctggttt  catctccaa  cgcgccgct  tgccggagc  cgggggcgc  600
ccggacgcc  agcgactgc  actacctga  cgcgaggtg  ccaaggaac  cggtgaccc  660
ggggacacc  ggaaggatt  ttgcacact  gtcaccatc  ccaagagct  gttggacct  720
aacaaatac  gacccatcc  gaccccctc  gtgtgcagc  acagtctgg  gagtcccga  780
gaggatata  gatccgaca  cgacgtgac  accgaatct  ggtcgagtc  ttcccacag  840
ccggaggag  gacaggatt  tggcagcgc  cccagcccg  tctccctcc  ccactctgg  900
gtggcttcg  aggggaaac  cgcctccga  aagaggcac  agtgcccct  cagtggctg  960
gggaaagtc  atggaaaat  ctcccatct  aaagcccat  acagagtgc  tacaggtga  1020
cggcccttc  cctgcacgt  gccagactg  cttaaaaag  tctcgcgct  ggacgagct  1080
acccgccac  accggaccc  cactggcga  aagcagttc  gctgtccgc  gtgtgagaa  1140
agattcatg  ggagtgacc  cctcaccaa  catgcccgg  gccacaccg  cttccaccc  1200
agcatgatc  agagatcaa  aaaggctct  gccagcccc  tgtgaggtg  tccccatat  1260
gcaaccagg  agagatggt  ccggaagga  agagctccc  ggaaacaga  ggacacatg  1320
aaatctgcc  ccgcagagt  gtgctggcc  caggaggtc  ctgctcttt  gtcaatatt  1380
tgacactct  cctgcgctg  ttccaaaaa  cacacggta  cctaagatc  aagtcaaca  1440
ttggtcccc  tgcagaggc  actctgaac  gtctctgac  gttggaggg  aggcaaata  1500
atgcttttg  tattttctc  tttgttttg  ggggtgggg  gagggggca  ggccaagac  1560
tggggtagg  tttttgaag  ttcaggctg  tgtacatac  tctgactgg  tgagttgac  1620
cctggcctc  cacagtgac  ctggatcct  gatgcttgc  gactctcag  attgttttt  1680
ttctctctc  atgtcacga  cagagtgct  cagcttgtt  agcagagcc  ctctcgaat  1740
acgttaact  ttgagattt  aaaaacaaa  caaaacaac  aaaaaaaaa  aaaacccct  1800
catagcaca  ctgtctttt  tgcaagcaa  agcacacct  ctccagcat  atctgtcat  1860
taaggactt  aaaacaaaa  aaaacaaaa  aaaaagtta  ttatagtca  tggataagc  1920
gagtccgaa  ttacactaa  caagacaga  cttcgaggg  tcataagtc  ggaactttc  1980
aaccttgct  cgtatgaat  gtactatct  aacataaac  gcactttta  tttctaata  2040
cgagggtga  tacggtaaa  ccatgcctt  agggtagaa  ccgacattc  gtttggcac  2100
cgttattat  tgcttattt  ccaggatac  catttccct  agaacccac  gcagagatg  2160
gagggcaga  tgtatggaa  cacatgctg  ggaggggaa  gaggagggg  gtgctttaa  2220
gatacaaaa  aaaaaaaaa  aaaaaaaag  gcaaacaat  ttaacttca  gaatttgtt  2280
gaattttcc  aagcttcag  taacaacgc  actcacggg  ctaggacgc  gcaagagca  2340
tgggctctg  gtagcatta  ctgataaat  ggtgtatag  catcaccag  cctggaaat  2400
ccccctttt  gtgggggtg  gggtgtttc  tggtctctc  ttcgttcct  tgaaatttc  2460
actaagagg  gcaagagtt  tatcaaagg  aagggaact  aaatatgga  aaaaaaaag  2520
ttgcccctg  aagtagtct  tagggaagg  agatgccac  atggtttca  aggcgactc  2580
gcagaacag  cccttctgc  gaacatagg  cagagaaac  ctcgtgaat  gcatcacat  2640
gccaactgt  tgcatcatg  cccaccact  cttagcttg  atctcggtg  ctacacaat  2700
gcctgaacc  ctggtcacc  t  2721



<210> 1644
<211> 244
<212> PRT
<213> Rattus norvegicus
<308> Q01713
<400> 1644

Met Ser Ala Ala Ala Tyr Met Asp Phe Val Ala Ala Gln Cys Leu Val 
  1               5                  10                  15
Ser Ile Ser Asn Arg Ala Ala Val Pro Glu His Gly Gly Ala Pro Asp 
             20                  25                  30
Ala Glu Arg Leu Arg Leu Pro Glu Arg Glu Val Thr Lys Glu His Gly 
         35                  40                  45
Asp Pro Gly Asp Thr Trp Lys Asp Tyr Cys Thr Leu Val Thr Ile Ala 
     50                  55                  60
Lys Ser Leu Leu Asp Leu Asn Lys Tyr Arg Pro Ile Gln Thr Pro Ser 
 65                  70                  75                  80
Val Cys Ser Asp Ser Leu Glu Ser Pro Asp Glu Asp Ile Gly Ser Asp 
                 85                  90                  95
Ser Asp Val Thr Thr Glu Ser Gly Ser Ser Pro Ser His Ser Pro Glu 
             100                105                110
Glu Arg Gln Asp Ser Gly Ser Ala Pro Ser Pro Leu Ser Leu Leu His 
         115                120                125
Ser Gly Val Ala Ser Lys Gly Lys His Ala Ser Glu Lys Arg His Lys 
     130                135                140
Cys Pro Tyr Ser Gly Cys Gly Lys Val Tyr Gly Lys Ser Ser His Leu 
 145                150                155                160
Lys Ala His Tyr Arg Val His Thr Gly Glu Arg Pro Phe Pro Cys Thr 
                 165                170                175
Trp Pro Asp Cys Leu Lys Lys Phe Ser Arg Ser Asp Glu Leu Thr Arg 
             180                185                190
His Tyr Arg Thr His Thr Gly Glu Lys Gln Phe Arg Cys Pro Leu Cys 
         195                200                205
Glu Lys Arg Phe Met Arg Ser Asp His Leu Thr Lys His Ala Arg Arg 
     210                215                220
His Thr Asp Phe His Pro Ser Met Ile Lys Arg Ser Lys Lys Ala Leu 
 225                230                235                240
Ala Ser Pro Leu 
                 245



<210> 1645
<211> 4859
<212> DNA
<213> Homo sapiens
<308> NM_001206
<400> 1645

cacgttggg  gacataatg  ggttttttt  attatagat  cacactgca  ttattcatc  60
cccctgtcc  ctcatccat  actcaaatt  actaccagc  acacaaaat  caaagatgt  120
tccagtttc  ctacagctc  tcgcgttta  aagtgtcga  cgcttgctt  cggaacgcc  180
ttgtgattg  ccgagccaa  gccagtgac  tcaaccaac  tacttttga  tggaaggct  240
gttgctggg  ctgtagcgt  tgcaggaag  cacttaact  tttgggagc  ggaaaaccg  300
agctgaagt  ctcttttgc  ataggaacg  gcgcaactg  ctaggaaag  tgtgtccca  360
agctccgca  gctggaacg  gagccagga  gcccggacc  gccacggga  cgcgaggca  420
tccgaaagt  tgcggctgc  ccttccctg  ctcccagct  ttacccttt  aaatgtcag  480
gttcgaggc  gtaggggta  cacgaggca  cgaaacgga  cagtcggat  ggccgcacg  540
ctcagttct  gacgcacct  tccaccgaa  ccgttctga  tggcagggg  agaaagtaa  600
cagagttga  tcaccctcc  cactggcca  ttggagggg  tttggtttg  gacgtgatg  660
gattctgcg  aattgttac  gagcaagag  atgccggaa  gtgcggacc  gccggagca  720
gggttcaga  gccgtcagt  gactcggga  aaagtgtct  ttagacctg  cgctcggcg  780
ggccctcgc  acccgcgtc  gggtgatcg  gtgaatgtc  tggggcttt  gctcgacgg  840
gaggcggcc  agggcgtgc  cctctcttg  agtttcctc  cccagcgcc  cgggggcgt  900
ttcagtcga  taaacttgc  accgccacg  gtggcatct  tccaaggga  ccggctcag  960
ggggccggc  cgcccgtcg  gggatcgcg  ccggcgcgg  gcaggggcg  cggctagag  1020
cggcggcgc  gcggagccc  gggccgtgg  tgctgcgtg  ggaggcgct  ccggttacg  1080
aaagatgag  ggctgaggt  gcctcggcg  tcctgcgag  cggaagcgc  ccgcgcccc  1140
gcccccttg  ccgccgcgc  gtgccgggc  ggcgggtcg  cgtccgagg  cagggaggg  1200
gagccgaac  tccgcagcc  ccgccaagt  tgtccgcgc  gcctgggct  ccgtcgccc  1260
caccatgtc  gcggccgcc  acatggact  cgtggctgc  cagtgtctg  tttccattt  1320
gaaccgcgc  gcggtgccg  agcatgggg  cgctccgga  gccgagcgg  tgcgactac  1380
tgagcgcga  gtgaccaag  agcacggtg  cccggggga  acctggaag  attactgca  1440
actggtcac  atcgccaag  gcttgttgg  cctgaacaa  taccgaccc  tccagaccc  1500
ctccgtgtg  agcgacagt  tggaaagtc  agatgagga  atgggatcc  acagcgacg  1560
gaccaccga  tctgggtcg  gtccttccc  cagcccgga  gagagacag  atcctggca  1620
cgcgcccag  ccgctctcc  tcctccatc  tggagtggc  gcgaagggg  aacacgcct  1680
cgaaaagag  cacaagtgc  cctacagtg  ctgtgggaa  gtctatgga  aatcctccc  1740
tctcaaagc  cattacaga  tgcatacag  tgaacggcc  ttcccctgc  cgtggccag  1800
ctgccttaa  aagttctcc  gctcagacg  gctgacccg  cactaccgg  cccacactg  1860
ggaaaagca  ttccgctgt  cgctgtgtg  gaagcgctt  atgaggagt  accacctca  1920
aaagcacgc  cggcggcac  ccgagttcc  ccccagcat  atcaagcga  cgaaaaagg  1980
gctggccaa  gctttgtga  gtgctgccc  tggaagcca  ggagggatg  accccgaaa  2040
gacaaaagt  ctcccagga  acagacgcg  gaaaactga  ccccagaag  ggcacactt  2100
acggcacag  aagtcactg  tctttggtc  atattctga  tttcctctc  ctgcattgt  2160
tttaaaaag  acattgtag  ctaagatca  agtcaacaa  actcggtcc  cttgaagag  2220
caactctct  aacccgtct  tgactgttg  agggaaggc  aatgctttt  ggttttttg  2280
tttttgttt  tgttttttt  tctcctttt  tttttttgc  ggggagggt  gggagtggg  2340
gggggggag  gggtaaggc  aagactggg  agattttaa  gattcaaca  tggtgtaca  2400
atgtccgct  ggtgagttg  cctgtggcc  cgcacagtg  ttctaggcc  tttatgctt  2460
ctgtctctc  gaattgttt  cttaccttt  aatgtaatg  cgagtgtgc  tcagtttgt  2520
tagcaaaac  actctcttg  atcacgtta  cttttgaga  taaaaaaaa  aacgccata  2580
cacagctgt  tttatgcaa  caagagcac  tctactcca  catgatctg  catctaaag  2640
cttgaaaac  aaaaacagt  acttatagt  aatgggtaa  cagagtctg  atttatact  2700
atcaagaca  acctttgaa  ggttacact  agtacagaa  ttttaaacc  tgctttgta  2760
gagttgtac  ttttgaaca  aagctgcac  tttattttc  aatgcagag  atgaataag  2820
taaatacat  ctttgagga  agaagcaga  gttctgttt  gcaccacgt  ataatctgc  2880
tattttaca  tatacacgt  tccctaaga  atcatgcgc  gagatgtga  ggcagaata  2940
acacaacag  tgctgaagg  gaaggaggg  agtgttttg  aaaagaaaa  gaaaagaac  3000
aacagaatt  taactctat  aacttttcc  aattttcct  tgcttttag  taacatcat  3060
attgtatcc  aatgccact  ggggagaga  cttttgact  tgttgggtt  tatttgaat  3120
tgtgcataa  agtaatgag  tctggaaac  cctattttt  ggggaaaaa  gtttgttgg  3180
ctccttcct  tgttcctac  aaactccca  tctcaggtg  aagagttat  tagaaggaa  3240
gggagctga  ataggaaca  aaaaatcaa  ccctataac  agtgaacac  aagggaaaa  3300
accacaatg  tttcagagg  gactctgca  aatcgtccc  tgtggagaa  gcaggcaac  3360
tggaatact  cgaatgaaa  cacatcact  tatctttta  atcaatagc  tcaccacta  3420
tatatcttg  atctaggtg  ctataatgg  tgaaaccac  acatccatc  atgccattt  3480
cctgaaaac  taactgtgg  ctttatgag  ccagaaaag  gaactgagt  ttgtagtta  3540
gacctcaaa  gaggggagt  agcagtgat  atgggggaa  tgtttacat  ttttttttc  3600
tcagaagta  cgctttctg  tgattttat  tgatattta  aacagggag  tatggtgca  3660
tctagttta  acttgcgct  tgaaatgtg  aaacatagg  tgcctacct  tttcacctg  3720
cccatactc  tttctgatt  agaatcagt  tgggctcct  cagtgggcg  gggtcacgg  3780
tgactccaa  ttccaatac  acagccatc  ctagcacag  gtttttttg  ttaaccaac  3840
tagtgttat  agtagttct  taaagagaa  tgcttttaa  attagggac  gggagcagt  3900
catgggata  aaaggaaag  gttttctca  gagaaaaca  gtcaggaaa  ataaagaac  3960
ctttctacc  ctgtttcag  tttttgaaa  acttatttt  aaccaaatt  taatttctg  4020
gtccaaaat  agttttaag  acatctgtt  ttccatacg  aataggtta  gctgcctat  4080
tctcactga  ctcatggaa  ggttctgct  atgatactc  gcacgctgc  ttttagtga  4140
tgaggagtt  ggggttgcc  agcacttgc  aacttgtaa  aagtcatct  tccctcaca  4200
aaagaaacg  aagaaagca  agcaaagtc  gtgaaagac  atctttata  tttcaggag  4260
aaatctaaa  gtggctttt  tcaagcact  agatggata  aaatgcagc  acttgtttt  4320
aaaaaatgc  catttactt  ccaaaaaag  tgttacttg  cttttcaag  gtgacaaac  4380
cacatttga  attctctta  atgttatag  aatgtaacg  ataaactca  gccttttta  4440
tctttgtga  taaatcctg  tttaaaatg  cacaaaaca  gaaccagca  tctaattag  4500
tttactata  caagatatg  ttcaaatag  actactaga  ttcattgaa  actaaaact  4560
tgaaacaat  actttttat  ttaaaaaga  catggattt  acttatgaa  atccaaatg  4620
aggatagta  tttttgttt  cttttttaa  caaactgaa  ttttgaaag  ctattgcag  4680
tgtttaaaa  gaaagaaaa  ttgttttat  taatactgt  agtagttgt  atattctgg  4740
aaatttaat  gttttagag  taagatatc  cctctcttt  gttagggaa  aagaaagcc  4800
ttcaccatt  tggaatgat  ccctggctt  aaggtttag  tccacatca  gcttctctt  4859



<210> 1646
<211> 244
<212> PRT
<213> Homo sapiens
<308> Q13886
<400> 1646

Met Ser Ala Ala Ala Tyr Met Asp Phe Val Ala Ala Gln Cys Leu Val 
  1               5                  10                  15
Ser Ile Ser Asn Arg Ala Ala Val Pro Glu His Gly Val Ala Pro Asp 
             20                  25                  30
Ala Glu Arg Leu Arg Leu Pro Glu Arg Glu Val Thr Lys Glu His Gly 
         35                  40                  45
Asp Pro Gly Asp Thr Trp Lys Asp Tyr Cys Thr Leu Val Thr Ile Ala 
     50                  55                  60
Lys Ser Leu Leu Asp Leu Asn Lys Tyr Arg Pro Ile Gln Thr Pro Ser 
 65                  70                  75                  80
Val Cys Ser Asp Ser Leu Glu Ser Pro Asp Glu Asp Met Gly Ser Asp 
                 85                  90                  95
Ser Asp Val Thr Thr Glu Ser Gly Ser Ser Pro Ser His Ser Pro Glu 
             100                105                110
Glu Arg Gln Asp Pro Gly Ser Ala Pro Ser Pro Leu Ser Leu Leu His 
         115                120                125
Pro Gly Val Ala Ala Lys Gly Lys His Ala Ser Glu Lys Arg His Lys 
     130                135                140
Cys Pro Tyr Ser Gly Cys Gly Lys Val Tyr Gly Lys Ser Ser His Leu 
 145                150                155                160
Lys Ala His Tyr Arg Val His Thr Gly Glu Arg Pro Phe Pro Cys Thr 
                 165                170                175
Trp Pro Asp Cys Leu Lys Lys Phe Ser Arg Ser Asp Glu Leu Thr Arg 
             180                185                190
His Tyr Arg Thr His Thr Gly Glu Lys Gln Phe Arg Cys Pro Leu Cys 
         195                200                205
Glu Lys Arg Phe Met Arg Ser Asp His Leu Thr Lys His Ala Arg Arg 
     210                215                220
His Thr Glu Phe His Pro Ser Met Ile Lys Arg Ser Lys Lys Ala Leu 
 225                230                235                240
Ala Asn Ala Leu 
                 245



<210> 1647
<211> 2721
<212> DNA
<213> Rattus norvegicus
<308> D12769
<400> 1647

gcggccgtc  gcggacgcg  gaagaagtg  cttgtaggc  cggcgcccc  ctcagcccc  60
gcccccctc  tccgcgtac  cggctgatg  ctcagggcg  cagctcggc  gagaggcgg  120
cgaggcgtg  gcctggcta  cagttggct  tccccgtga  tcggacacg  ttgcagtcg  180
ataaacttg  gaccgccac  tgtggcatc  ctccaagga  ccggctcag  aggagggcg  240
gcccatcgt  ggatcgcgc  gggcgcccg  cagggcggc  gcgacagcg  cagagccgg  300
cgcggctgc  gcgtgcgga  gcgctgccg  ttacgtaaa  atgaggggc  gaggtcgcc  360
cggcgctcc  gcgagtcgc  agctcccgc  cccccgccc  ctcggccgc  ccgcaccgc  420
ctcgtcgtc  gagaccagg  cagggctag  cgaagctcc  cagccaccc  caagtttgg  480
cgcaccgcc  gggctgccg  cgcccgcac  atgtccgcg  ccgcctaca  ggacttcgt  540
gctgcccag  gtctggttt  catctccaa  cgcgccgct  tgccggagc  cgggggcgc  600
ccggacgcc  agcgactgc  actacctga  cgcgaggtg  ccaaggaac  cggtgaccc  660
ggggacacc  ggaaggatt  ttgcacact  gtcaccatc  ccaagagct  gttggacct  720
aacaaatac  gacccatcc  gaccccctc  gtgtgcagc  acagtctgg  gagtcccga  780
gaggatata  gatccgaca  cgacgtgac  accgaatct  ggtcgagtc  ttcccacag  840
ccggaggag  gacaggatt  tggcagcgc  cccagcccg  tctccctcc  ccactctgg  900
gtggcttcg  aggggaaac  cgcctccga  aagaggcac  agtgcccct  cagtggctg  960
gggaaagtc  atggaaaat  ctcccatct  aaagcccat  acagagtgc  tacaggtga  1020
cggcccttc  cctgcacgt  gccagactg  cttaaaaag  tctcgcgct  ggacgagct  1080
acccgccac  accggaccc  cactggcga  aagcagttc  gctgtccgc  gtgtgagaa  1140
agattcatg  ggagtgacc  cctcaccaa  catgcccgg  gccacaccg  cttccaccc  1200
agcatgatc  agagatcaa  aaaggctct  gccagcccc  tgtgaggtg  tccccatat  1260
gcaaccagg  agagatggt  ccggaagga  agagctccc  ggaaacaga  ggacacatg  1320
aaatctgcc  ccgcagagt  gtgctggcc  caggaggtc  ctgctcttt  gtcaatatt  1380
tgacactct  cctgcgctg  ttccaaaaa  cacacggta  cctaagatc  aagtcaaca  1440
ttggtcccc  tgcagaggc  actctgaac  gtctctgac  gttggaggg  aggcaaata  1500
atgcttttg  tattttctc  tttgttttg  ggggtgggg  gagggggca  ggccaagac  1560
tggggtagg  tttttgaag  ttcaggctg  tgtacatac  tctgactgg  tgagttgac  1620
cctggcctc  cacagtgac  ctggatcct  gatgcttgc  gactctcag  attgttttt  1680
ttctctctc  atgtcacga  cagagtgct  cagcttgtt  agcagagcc  ctctcgaat  1740
acgttaact  ttgagattt  aaaaacaaa  caaaacaac  aaaaaaaaa  aaaacccct  1800
catagcaca  ctgtctttt  tgcaagcaa  agcacacct  ctccagcat  atctgtcat  1860
taaggactt  aaaacaaaa  aaaacaaaa  aaaaagtta  ttatagtca  tggataagc  1920
gagtccgaa  ttacactaa  caagacaga  cttcgaggg  tcataagtc  ggaactttc  1980
aaccttgct  cgtatgaat  gtactatct  aacataaac  gcactttta  tttctaata  2040
cgagggtga  tacggtaaa  ccatgcctt  agggtagaa  ccgacattc  gtttggcac  2100
cgttattat  tgcttattt  ccaggatac  catttccct  agaacccac  gcagagatg  2160
gagggcaga  tgtatggaa  cacatgctg  ggaggggaa  gaggagggg  gtgctttaa  2220
gatacaaaa  aaaaaaaaa  aaaaaaaag  gcaaacaat  ttaacttca  gaatttgtt  2280
gaattttcc  aagcttcag  taacaacgc  actcacggg  ctaggacgc  gcaagagca  2340
tgggctctg  gtagcatta  ctgataaat  ggtgtatag  catcaccag  cctggaaat  2400
ccccctttt  gtgggggtg  gggtgtttc  tggtctctc  ttcgttcct  tgaaatttc  2460
actaagagg  gcaagagtt  tatcaaagg  aagggaact  aaatatgga  aaaaaaaag  2520
ttgcccctg  aagtagtct  tagggaagg  agatgccac  atggtttca  aggcgactc  2580
gcagaacag  cccttctgc  gaacatagg  cagagaaac  ctcgtgaat  gcatcacat  2640
gccaactgt  tgcatcatg  cccaccact  cttagcttg  atctcggtg  ctacacaat  2700
gcctgaacc  ctggtcacc  t  2721



<210> 1648
<211> 244
<212> PRT
<213> Rattus norvegicus
<308> Q01713
<400> 1648

Met Ser Ala Ala Ala Tyr Met Asp Phe Val Ala Ala Gln Cys Leu Val 
  1               5                  10                  15
Ser Ile Ser Asn Arg Ala Ala Val Pro Glu His Gly Gly Ala Pro Asp 
             20                  25                  30
Ala Glu Arg Leu Arg Leu Pro Glu Arg Glu Val Thr Lys Glu His Gly 
         35                  40                  45
Asp Pro Gly Asp Thr Trp Lys Asp Tyr Cys Thr Leu Val Thr Ile Ala 
     50                  55                  60
Lys Ser Leu Leu Asp Leu Asn Lys Tyr Arg Pro Ile Gln Thr Pro Ser 
 65                  70                  75                  80
Val Cys Ser Asp Ser Leu Glu Ser Pro Asp Glu Asp Ile Gly Ser Asp 
                 85                  90                  95
Ser Asp Val Thr Thr Glu Ser Gly Ser Ser Pro Ser His Ser Pro Glu 
             100                105                110
Glu Arg Gln Asp Ser Gly Ser Ala Pro Ser Pro Leu Ser Leu Leu His 
         115                120                125
Ser Gly Val Ala Ser Lys Gly Lys His Ala Ser Glu Lys Arg His Lys 
     130                135                140
Cys Pro Tyr Ser Gly Cys Gly Lys Val Tyr Gly Lys Ser Ser His Leu 
 145                150                155                160
Lys Ala His Tyr Arg Val His Thr Gly Glu Arg Pro Phe Pro Cys Thr 
                 165                170                175
Trp Pro Asp Cys Leu Lys Lys Phe Ser Arg Ser Asp Glu Leu Thr Arg 
             180                185                190
His Tyr Arg Thr His Thr Gly Glu Lys Gln Phe Arg Cys Pro Leu Cys 
         195                200                205
Glu Lys Arg Phe Met Arg Ser Asp His Leu Thr Lys His Ala Arg Arg 
     210                215                220
His Thr Asp Phe His Pro Ser Met Ile Lys Arg Ser Lys Lys Ala Leu 
 225                230                235                240
Ala Ser Pro Leu 
                 245



<210> 1649
<211> 4859
<212> DNA
<213> Homo sapiens
<308> NM_001206
<400> 1649

cacgttggg  gacataatg  ggttttttt  attatagat  cacactgca  ttattcatc  60
cccctgtcc  ctcatccat  actcaaatt  actaccagc  acacaaaat  caaagatgt  120
tccagtttc  ctacagctc  tcgcgttta  aagtgtcga  cgcttgctt  cggaacgcc  180
ttgtgattg  ccgagccaa  gccagtgac  tcaaccaac  tacttttga  tggaaggct  240
gttgctggg  ctgtagcgt  tgcaggaag  cacttaact  tttgggagc  ggaaaaccg  300
agctgaagt  ctcttttgc  ataggaacg  gcgcaactg  ctaggaaag  tgtgtccca  360
agctccgca  gctggaacg  gagccagga  gcccggacc  gccacggga  cgcgaggca  420
tccgaaagt  tgcggctgc  ccttccctg  ctcccagct  ttacccttt  aaatgtcag  480
gttcgaggc  gtaggggta  cacgaggca  cgaaacgga  cagtcggat  ggccgcacg  540
ctcagttct  gacgcacct  tccaccgaa  ccgttctga  tggcagggg  agaaagtaa  600
cagagttga  tcaccctcc  cactggcca  ttggagggg  tttggtttg  gacgtgatg  660
gattctgcg  aattgttac  gagcaagag  atgccggaa  gtgcggacc  gccggagca  720
gggttcaga  gccgtcagt  gactcggga  aaagtgtct  ttagacctg  cgctcggcg  780
ggccctcgc  acccgcgtc  gggtgatcg  gtgaatgtc  tggggcttt  gctcgacgg  840
gaggcggcc  agggcgtgc  cctctcttg  agtttcctc  cccagcgcc  cgggggcgt  900
ttcagtcga  taaacttgc  accgccacg  gtggcatct  tccaaggga  ccggctcag  960
ggggccggc  cgcccgtcg  gggatcgcg  ccggcgcgg  gcaggggcg  cggctagag  1020
cggcggcgc  gcggagccc  gggccgtgg  tgctgcgtg  ggaggcgct  ccggttacg  1080
aaagatgag  ggctgaggt  gcctcggcg  tcctgcgag  cggaagcgc  ccgcgcccc  1140
gcccccttg  ccgccgcgc  gtgccgggc  ggcgggtcg  cgtccgagg  cagggaggg  1200
gagccgaac  tccgcagcc  ccgccaagt  tgtccgcgc  gcctgggct  ccgtcgccc  1260
caccatgtc  gcggccgcc  acatggact  cgtggctgc  cagtgtctg  tttccattt  1320
gaaccgcgc  gcggtgccg  agcatgggg  cgctccgga  gccgagcgg  tgcgactac  1380
tgagcgcga  gtgaccaag  agcacggtg  cccggggga  acctggaag  attactgca  1440
actggtcac  atcgccaag  gcttgttgg  cctgaacaa  taccgaccc  tccagaccc  1500
ctccgtgtg  agcgacagt  tggaaagtc  agatgagga  atgggatcc  acagcgacg  1560
gaccaccga  tctgggtcg  gtccttccc  cagcccgga  gagagacag  atcctggca  1620
cgcgcccag  ccgctctcc  tcctccatc  tggagtggc  gcgaagggg  aacacgcct  1680
cgaaaagag  cacaagtgc  cctacagtg  ctgtgggaa  gtctatgga  aatcctccc  1740
tctcaaagc  cattacaga  tgcatacag  tgaacggcc  ttcccctgc  cgtggccag  1800
ctgccttaa  aagttctcc  gctcagacg  gctgacccg  cactaccgg  cccacactg  1860
ggaaaagca  ttccgctgt  cgctgtgtg  gaagcgctt  atgaggagt  accacctca  1920
aaagcacgc  cggcggcac  ccgagttcc  ccccagcat  atcaagcga  cgaaaaagg  1980
gctggccaa  gctttgtga  gtgctgccc  tggaagcca  ggagggatg  accccgaaa  2040
gacaaaagt  ctcccagga  acagacgcg  gaaaactga  ccccagaag  ggcacactt  2100
acggcacag  aagtcactg  tctttggtc  atattctga  tttcctctc  ctgcattgt  2160
tttaaaaag  acattgtag  ctaagatca  agtcaacaa  actcggtcc  cttgaagag  2220
caactctct  aacccgtct  tgactgttg  agggaaggc  aatgctttt  ggttttttg  2280
tttttgttt  tgttttttt  tctcctttt  tttttttgc  ggggagggt  gggagtggg  2340
gggggggag  gggtaaggc  aagactggg  agattttaa  gattcaaca  tggtgtaca  2400
atgtccgct  ggtgagttg  cctgtggcc  cgcacagtg  ttctaggcc  tttatgctt  2460
ctgtctctc  gaattgttt  cttaccttt  aatgtaatg  cgagtgtgc  tcagtttgt  2520
tagcaaaac  actctcttg  atcacgtta  cttttgaga  taaaaaaaa  aacgccata  2580
cacagctgt  tttatgcaa  caagagcac  tctactcca  catgatctg  catctaaag  2640
cttgaaaac  aaaaacagt  acttatagt  aatgggtaa  cagagtctg  atttatact  2700
atcaagaca  acctttgaa  ggttacact  agtacagaa  ttttaaacc  tgctttgta  2760
gagttgtac  ttttgaaca  aagctgcac  tttattttc  aatgcagag  atgaataag  2820
taaatacat  ctttgagga  agaagcaga  gttctgttt  gcaccacgt  ataatctgc  2880
tattttaca  tatacacgt  tccctaaga  atcatgcgc  gagatgtga  ggcagaata  2940
acacaacag  tgctgaagg  gaaggaggg  agtgttttg  aaaagaaaa  gaaaagaac  3000
aacagaatt  taactctat  aacttttcc  aattttcct  tgcttttag  taacatcat  3060
attgtatcc  aatgccact  ggggagaga  cttttgact  tgttgggtt  tatttgaat  3120
tgtgcataa  agtaatgag  tctggaaac  cctattttt  ggggaaaaa  gtttgttgg  3180
ctccttcct  tgttcctac  aaactccca  tctcaggtg  aagagttat  tagaaggaa  3240
gggagctga  ataggaaca  aaaaatcaa  ccctataac  agtgaacac  aagggaaaa  3300
accacaatg  tttcagagg  gactctgca  aatcgtccc  tgtggagaa  gcaggcaac  3360
tggaatact  cgaatgaaa  cacatcact  tatctttta  atcaatagc  tcaccacta  3420
tatatcttg  atctaggtg  ctataatgg  tgaaaccac  acatccatc  atgccattt  3480
cctgaaaac  taactgtgg  ctttatgag  ccagaaaag  gaactgagt  ttgtagtta  3540
gacctcaaa  gaggggagt  agcagtgat  atgggggaa  tgtttacat  ttttttttc  3600
tcagaagta  cgctttctg  tgattttat  tgatattta  aacagggag  tatggtgca  3660
tctagttta  acttgcgct  tgaaatgtg  aaacatagg  tgcctacct  tttcacctg  3720
cccatactc  tttctgatt  agaatcagt  tgggctcct  cagtgggcg  gggtcacgg  3780
tgactccaa  ttccaatac  acagccatc  ctagcacag  gtttttttg  ttaaccaac  3840
tagtgttat  agtagttct  taaagagaa  tgcttttaa  attagggac  gggagcagt  3900
catgggata  aaaggaaag  gttttctca  gagaaaaca  gtcaggaaa  ataaagaac  3960
ctttctacc  ctgtttcag  tttttgaaa  acttatttt  aaccaaatt  taatttctg  4020
gtccaaaat  agttttaag  acatctgtt  ttccatacg  aataggtta  gctgcctat  4080
tctcactga  ctcatggaa  ggttctgct  atgatactc  gcacgctgc  ttttagtga  4140
tgaggagtt  ggggttgcc  agcacttgc  aacttgtaa  aagtcatct  tccctcaca  4200
aaagaaacg  aagaaagca  agcaaagtc  gtgaaagac  atctttata  tttcaggag  4260
aaatctaaa  gtggctttt  tcaagcact  agatggata  aaatgcagc  acttgtttt  4320
aaaaaatgc  catttactt  ccaaaaaag  tgttacttg  cttttcaag  gtgacaaac  4380
cacatttga  attctctta  atgttatag  aatgtaacg  ataaactca  gccttttta  4440
tctttgtga  taaatcctg  tttaaaatg  cacaaaaca  gaaccagca  tctaattag  4500
tttactata  caagatatg  ttcaaatag  actactaga  ttcattgaa  actaaaact  4560
tgaaacaat  actttttat  ttaaaaaga  catggattt  acttatgaa  atccaaatg  4620
aggatagta  tttttgttt  cttttttaa  caaactgaa  ttttgaaag  ctattgcag  4680
tgtttaaaa  gaaagaaaa  ttgttttat  taatactgt  agtagttgt  atattctgg  4740
aaatttaat  gttttagag  taagatatc  cctctcttt  gttagggaa  aagaaagcc  4800
ttcaccatt  tggaatgat  ccctggctt  aaggtttag  tccacatca  gcttctctt  4859



<210> 1650
<211> 244
<212> PRT
<213> Homo sapiens
<308> Q13886
<400> 1650

Met Ser Ala Ala Ala Tyr Met Asp Phe Val Ala Ala Gln Cys Leu Val 
  1               5                  10                  15
Ser Ile Ser Asn Arg Ala Ala Val Pro Glu His Gly Val Ala Pro Asp 
             20                  25                  30
Ala Glu Arg Leu Arg Leu Pro Glu Arg Glu Val Thr Lys Glu His Gly 
         35                  40                  45
Asp Pro Gly Asp Thr Trp Lys Asp Tyr Cys Thr Leu Val Thr Ile Ala 
     50                  55                  60
Lys Ser Leu Leu Asp Leu Asn Lys Tyr Arg Pro Ile Gln Thr Pro Ser 
 65                  70                  75                  80
Val Cys Ser Asp Ser Leu Glu Ser Pro Asp Glu Asp Met Gly Ser Asp 
                 85                  90                  95
Ser Asp Val Thr Thr Glu Ser Gly Ser Ser Pro Ser His Ser Pro Glu 
             100                105                110
Glu Arg Gln Asp Pro Gly Ser Ala Pro Ser Pro Leu Ser Leu Leu His 
         115                120                125
Pro Gly Val Ala Ala Lys Gly Lys His Ala Ser Glu Lys Arg His Lys 
     130                135                140
Cys Pro Tyr Ser Gly Cys Gly Lys Val Tyr Gly Lys Ser Ser His Leu 
 145                150                155                160
Lys Ala His Tyr Arg Val His Thr Gly Glu Arg Pro Phe Pro Cys Thr 
                 165                170                175
Trp Pro Asp Cys Leu Lys Lys Phe Ser Arg Ser Asp Glu Leu Thr Arg 
             180                185                190
His Tyr Arg Thr His Thr Gly Glu Lys Gln Phe Arg Cys Pro Leu Cys 
         195                200                205
Glu Lys Arg Phe Met Arg Ser Asp His Leu Thr Lys His Ala Arg Arg 
     210                215                220
His Thr Glu Phe His Pro Ser Met Ile Lys Arg Ser Lys Lys Ala Leu 
 225                230                235                240
Ala Asn Ala Leu 
                 245



<210> 1651
<211> 1151
<212> DNA
<213> Rattus norvegicus
<308> D12927
<400> 1651

cggaccgcg  atctaggcg  cggcggccg  ggtccggcc  ggcggcgca  ccggcgcaa  60
ccgccgcca  cgaggtagt  atgggcaag  aggaggaga  tgctcgtat  gcccggagg  120
tggacaaaa  ggtgaccag  aagaacgcg  agggagcca  ggatttgct  cgggagctg  180
agaatatgc  tattacatt  cacttgctc  agtccaccc  tgttgggat  tctgtcaac  240
ctctgcgga  gcagagttc  gacgaggag  tcattgcac  tgccaagtc  ctcatcaag  300
cctggaaga  gctcttgga  gtttctgat  gcaaatcca  ggatcaagg  aggggcaca  360
ctttgccta  atcgtcctc  aaggatgcc  cagggacta  ggatctcag  tgcaagaaa  420
cagacccac  taggacctc  tccactccg  ggatcacca  atttcccca  gtgcccatc  480
cctgtgatg  tgtgcgaaa  aaatgtcgt  agatgctga  tttggccct  caaactgac  540
acgaccacg  ggctgttgg  gtgagctgt  agcatctgt  atctcagat  gaggagtgc  600
tcttcctgg  tgtgggaaa  actgacatg  agtacaaga  ccgtgttcg  agccgaatc  660
ctaacctga  agatgccaa  aaccctggc  tacgccgga  tgtgttgtg  ggtgccatt  720
caccccagc  gatagctgt  atgacatca  aggagatgg  cagtgacga  ctgaaggag  780
tccgcaagg  tatgaccaa  gaggccatc  gagagcacc  gatggcccg  acaggtggc  840
cacagaccg  cctgttcac  tgcaacaag  gcaggaaga  gaactgcac  tacacgcag  900
tgcagaccc  tagctctga  gagcccatg  ccacctatg  tgtctgcaa  gagtgtggg  960
atcgatgga  gttctgctg  gtccttgta  tgatgtagc  ctggccatg  ctaaccctg  1020
acctcctgc  acgctcttg  tggacacag  ttctctgga  ataccctgc  ggtggcatg  1080
cccgttcca  cctgcctgg  gtgcacctg  ctgcccttt  cccctcatc  ttaaatgtt  1140
ctttttgcc  t  1151



<210> 1652
<211> 299
<212> PRT
<213> Rattus norvegicus
<308> BAA02310
<400> 1652

Met Gly Lys Glu Glu Glu Ile Ala Arg Ile Ala Arg Arg Leu Asp Lys 
  1               5                  10                  15
Met Val Thr Arg Lys Asn Ala Glu Gly Ala Met Asp Leu Leu Arg Glu 
             20                  25                  30
Leu Lys Asn Met Pro Ile Thr Leu His Leu Leu Gln Ser Thr Arg Val 
         35                  40                  45
Gly Met Ser Val Asn Ala Leu Arg Lys Gln Ser Ser Asp Glu Glu Leu 
     50                  55                  60
Ile Ala Leu Ala Lys Ser Leu Ile Lys Ser Trp Lys Lys Leu Leu Asp 
 65                  70                  75                  80
Val Ser Asp Gly Lys Ser Arg Asp Gln Gly Arg Gly Thr Pro Leu Pro 
                 85                  90                  95
Thr Ser Ser Ser Lys Asp Ala Ser Gly Thr Thr Asp Leu Ser Cys Lys 
             100                105                110
Lys Pro Asp Pro Pro Arg Thr Ser Ser Thr Pro Arg Ile Thr Thr Phe 
         115                120                125
Pro Gln Val Pro Ile Thr Cys Asp Ala Val Arg Asn Lys Cys Arg Glu 
     130                135                140
Met Leu Thr Leu Ala Leu Gln Thr Asp His Asp His Val Ala Val Gly 
 145                150                155                160
Val Ser Cys Glu His Leu Ser Ser Gln Ile Glu Glu Cys Ile Phe Leu 
                 165                170                175
Asp Val Gly Asn Thr Asp Met Lys Tyr Lys Asn Arg Val Arg Ser Arg 
             180                185                190
Ile Ser Asn Leu Lys Asp Ala Lys Asn Pro Gly Leu Arg Arg Asn Val 
         195                200                205
Leu Cys Gly Ala Ile Thr Pro Gln Gln Ile Ala Val Met Thr Ser Glu 
     210                215                220
Glu Met Ala Ser Asp Glu Leu Lys Glu Ile Arg Lys Ala Met Thr Lys 
 225                230                235                240
Glu Ala Ile Arg Glu His Gln Met Ala Arg Thr Gly Gly Thr Gln Thr 
                 245                250                255
Asp Leu Phe Thr Cys Asn Lys Cys Arg Lys Lys Asn Cys Thr Tyr Thr 
             260                265                270
Gln Val Gln Thr Arg Ser Ser Asp Glu Pro Met Thr Thr Tyr Val Val 
         275                280                285
Cys Asn Glu Cys Gly Asn Arg Trp Lys Phe Cys 
     290                295



<210> 1653
<211> 1204
<212> DNA
<213> Homo sapiens
<308> NM_003195
<400> 1653

ggcacgagg  tcggctgcg  cgggtgtgg  aggtggcga  ggccggggc  ggggtcctg  60
ccggctgcg  aggcgggcg  gacgggcgc  ggggtcgct  ctcctgagg  gatgatggg  120
aaggaagag  agattgcgc  gatcgcccg  aggctggac  agatggtga  caagaagag  180
gcggaggga  ccatggatt  gctgcggga  ctgaaggcc  tgcctatca  gctgcacct  240
ctccagtcc  cccgagtcg  gatgtctgt  aacgccctt  ggaagcaga  ctcggatga  300
gaggtcatt  cactggcca  gtctctcat  aagtcctgg  agaagctcc  ggatgcttc  360
gatgccaaa  ccagggagc  ggggagggg  atgcctctg  ccacgtcct  gagggatgc  420
tcagaggcc  cggatccca  ccgcaagag  ccggagctg  ccagggcac  gtcgactcc  480
aggatcacc  catttcctc  ggtgcctgt  acctgtgat  ccgtgcgca  caagtgccg  540
gagatgctg  ccgctgccc  gcagacgga  catgaccac  tggccatcg  tgcggactg  600
gagcgcctg  cggctcaga  cgaggaatg  atcttccgg  acgttggaa  cacagacat  660
aagtataag  accgtgtac  gagtcgtat  tccaacctg  aggatgcca  gaaccctga  720
ctgcggcgg  atgtgctgt  tggggccat  acaccccag  agatcgctg  gatgacctc  780
gaggagatg  ccagtgatg  gctgaagga  atccgtaag  ccatgacca  ggaggccat  840
cgagagcac  agatggccc  cactggcgg  acgcagaca  acctgttca  ctgcggcaa  900
tgcaggaaa  agaactgca  ctacacaca  gtgcagacc  gcagctctg  tgagcccat  960
accaccttt  ttgtctgca  cgagtgtgg  aaccgctgg  agttctgct  acccctcgt  1020
tagatgtgc  gcagccttg  gccctcccc  gcccacgtc  tccgttgac  cagcttctc  1080
ggagaccct  gaaggcggc  tgtcctgcc  tcaacctgc  tgcctggat  gcacctttc  1140
gccctttcc  cctcattat  aaatgtttc  ttttgccaa  aaaaacaaa  aaaaaaaaa  1200
aaaa  1204



<210> 1654
<211> 299
<212> PRT
<213> Homo sapiens
<308> NP_003186
<400> 1654

Met Met Gly Lys Glu Glu Glu Ile Ala Arg Ile Ala Arg Arg Leu Asp 
  1               5                  10                  15
Lys Met Val Thr Lys Lys Ser Ala Glu Gly Ala Met Asp Leu Leu Arg 
             20                  25                  30
Glu Leu Lys Ala Met Pro Ile Thr Leu His Leu Leu Gln Ser Thr Arg 
         35                  40                  45
Val Gly Met Ser Val Asn Ala Leu Arg Lys Gln Ser Ser Asp Glu Glu 
     50                  55                  60
Val Ile Ala Leu Ala Lys Ser Leu Ile Lys Ser Trp Lys Lys Leu Leu 
 65                  70                  75                  80
Asp Ala Ser Asp Ala Lys Ala Arg Glu Arg Gly Arg Gly Met Pro Leu 
                 85                  90                  95
Pro Thr Ser Ser Arg Asp Ala Ser Glu Ala Pro Asp Pro Ser Arg Lys 
             100                105                110
Arg Pro Glu Leu Pro Arg Ala Pro Ser Thr Pro Arg Ile Thr Thr Phe 
         115                120                125
Pro Pro Val Pro Val Thr Cys Asp Ala Val Arg Asn Lys Cys Arg Glu 
     130                135                140
Met Leu Thr Ala Ala Leu Gln Thr Asp His Asp His Val Ala Ile Gly 
 145                150                155                160
Ala Asp Cys Glu Arg Leu Ser Ala Gln Ile Glu Glu Cys Ile Phe Arg 
                 165                170                175
Asp Val Gly Asn Thr Asp Met Lys Tyr Lys Asn Arg Val Arg Ser Arg 
             180                185                190
Ile Ser Asn Leu Lys Asp Ala Lys Asn Pro Asp Leu Arg Arg Asn Val 
         195                200                205
Leu Cys Gly Ala Ile Thr Pro Gln Gln Ile Ala Val Met Thr Ser Glu 
     210                215                220
Glu Met Ala Ser Asp Glu Leu Lys Glu Ile Arg Lys Ala Met Thr Lys 
 225                230                235                240
Glu Ala Ile Arg Glu His Gln Met Ala Arg Thr Gly Gly Thr Gln Thr 
                 245                250                255
Asp Leu Phe Thr Cys Gly Lys Cys Arg Lys Lys Asn Cys Thr Tyr Thr 
             260                265                270
Gln Val Gln Thr Arg Ser Ser Asp Glu Pro Met Thr Thr Phe Val Val 
         275                280                285
Cys Asn Glu Cys Gly Asn Arg Trp Lys Phe Cys 
     290                295



<210> 1655
<211> 481
<212> DNA
<213> Rattus norvegicus
<308> D13122
<400> 1655

caaccacgc  cgcaacgga  ctgagcaac  ccgaagata  tggcaggct  ggcgttggc  60
gttcgggct  ggctcggtg  ctggggtat  agggtcctg  aaacccgag  cttcggctc  120
gactcgtcg  agagcatgg  ttcgggcgc  ggctccatc  gagaagctg  tggggcctt  180
gggaaacga  agaaggctg  agaggatcg  tacttccga  agaagacta  agagcagct  240
gctgccttg  agaagcacc  tgaagatga  attgaccac  attcgaagg  gatagagcg  300
ctgcaaaaa  agatcgaac  gcataagaa  aagattaaa  acctaaaga  tagtgagca  360
tgagtgcac  cagtcagtc  ctcacagag  ggccagtat  attccccac  tctatagag  420
ttgttttga  tgattgatg  ttgacctgt  tgctactaa  agataataa  ttatcacca  480
g  481



<210> 1656
<211> 107
<212> PRT
<213> Rattus norvegicus
<308> Q03344
<400> 1656

Met Ala Gly Ser Ala Leu Ala Val Arg Ala Arg Leu Gly Val Trp Gly 
  1               5                  10                  15
Met Arg Val Leu Gln Thr Arg Gly Phe Gly Ser Asp Ser Ser Glu Ser 
             20                  25                  30
Met Asp Ser Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
         35                  40                  45
Lys Arg Glu Lys Ala Glu Glu Asp Arg Tyr Phe Arg Glu Lys Thr Arg 
     50                  55                  60
Glu Gln Leu Ala Ala Leu Lys Lys His His Glu Asp Glu Ile Asp His 
 65                  70                  75                  80
His Ser Lys Glu Ile Glu Arg Leu Gln Lys Gln Ile Glu Arg His Lys 
                 85                  90                  95
Lys Lys Ile Lys Tyr Leu Lys Asn Ser Glu His 
             100                105



<210> 1657
<211> 515
<212> DNA
<213> Homo sapiens
<308> NM_016311
<400> 1657

cgagagact  cttgctgcg  cagagacgc  agaggtgca  ctccagcag  aatggcagt  60
acggcgttg  cggcgcgga  gtggcttgg  gtgtggggc  tgaggacca  gcaagcccg  120
ggcttcggc  cggatcagt  cgagaatgt  gaccggggc  cgggctcca  ccgggaagc  180
ggtggggcc  tcggaaaga  agagcaggc  gaagaggaa  gatatttcc  agcacagag  240
agagaacaa  tggcagctt  gaaaaaaca  catgaagaa  aaatcgttc  tcataagaa  300
gagattgag  gtctgcaga  agaaattga  cgccataag  agaagatca  aatgctaaa  360
catgatgat  aagtgcaca  cgtgtgcca  agaatggca  atgtcattg  ccacttctg  420
gtagacatg  ttctggttt  actaatatt  gtctgtgtg  tactaacag  ttataataa  480
ttgtcatca  tgaaaaaaa  aaaaaaaaa  aaaaa  515



<210> 1658
<211> 106
<212> PRT
<213> Homo sapiens
<308> Q9UII2
<400> 1658

Met Ala Val Thr Ala Leu Ala Ala Arg Thr Trp Leu Gly Val Trp Gly 
  1               5                  10                  15
Val Arg Thr Met Gln Ala Arg Gly Phe Gly Ser Asp Gln Ser Glu Asn 
             20                  25                  30
Val Asp Arg Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
         35                  40                  45
Lys Arg Glu Gln Ala Glu Glu Glu Arg Tyr Phe Arg Ala Gln Ser Arg 
     50                  55                  60
Glu Gln Leu Ala Ala Leu Lys Lys His His Glu Glu Glu Ile Val His 
 65                  70                  75                  80
His Lys Lys Glu Ile Glu Arg Leu Gln Lys Glu Ile Glu Arg His Lys 
                 85                  90                  95
Gln Lys Ile Lys Met Leu Lys His Asp Asp 
             100                105



<210> 1659
<211> 481
<212> DNA
<213> Rattus norvegicus
<308> D13122
<400> 1659

caaccacgc  cgcaacgga  ctgagcaac  ccgaagata  tggcaggct  ggcgttggc  60
gttcgggct  ggctcggtg  ctggggtat  agggtcctg  aaacccgag  cttcggctc  120
gactcgtcg  agagcatgg  ttcgggcgc  ggctccatc  gagaagctg  tggggcctt  180
gggaaacga  agaaggctg  agaggatcg  tacttccga  agaagacta  agagcagct  240
gctgccttg  agaagcacc  tgaagatga  attgaccac  attcgaagg  gatagagcg  300
ctgcaaaaa  agatcgaac  gcataagaa  aagattaaa  acctaaaga  tagtgagca  360
tgagtgcac  cagtcagtc  ctcacagag  ggccagtat  attccccac  tctatagag  420
ttgttttga  tgattgatg  ttgacctgt  tgctactaa  agataataa  ttatcacca  480
g  481



<210> 1660
<211> 107
<212> PRT
<213> Rattus norvegicus
<308> Q03344
<400> 1660

Met Ala Gly Ser Ala Leu Ala Val Arg Ala Arg Leu Gly Val Trp Gly 
  1               5                  10                  15
Met Arg Val Leu Gln Thr Arg Gly Phe Gly Ser Asp Ser Ser Glu Ser 
             20                  25                  30
Met Asp Ser Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
         35                  40                  45
Lys Arg Glu Lys Ala Glu Glu Asp Arg Tyr Phe Arg Glu Lys Thr Arg 
     50                  55                  60
Glu Gln Leu Ala Ala Leu Lys Lys His His Glu Asp Glu Ile Asp His 
 65                  70                  75                  80
His Ser Lys Glu Ile Glu Arg Leu Gln Lys Gln Ile Glu Arg His Lys 
                 85                  90                  95
Lys Lys Ile Lys Tyr Leu Lys Asn Ser Glu His 
             100                105



<210> 1661
<211> 515
<212> DNA
<213> Homo sapiens
<308> NM_016311
<400> 1661

cgagagact  cttgctgcg  cagagacgc  agaggtgca  ctccagcag  aatggcagt  60
acggcgttg  cggcgcgga  gtggcttgg  gtgtggggc  tgaggacca  gcaagcccg  120
ggcttcggc  cggatcagt  cgagaatgt  gaccggggc  cgggctcca  ccgggaagc  180
ggtggggcc  tcggaaaga  agagcaggc  gaagaggaa  gatatttcc  agcacagag  240
agagaacaa  tggcagctt  gaaaaaaca  catgaagaa  aaatcgttc  tcataagaa  300
gagattgag  gtctgcaga  agaaattga  cgccataag  agaagatca  aatgctaaa  360
catgatgat  aagtgcaca  cgtgtgcca  agaatggca  atgtcattg  ccacttctg  420
gtagacatg  ttctggttt  actaatatt  gtctgtgtg  tactaacag  ttataataa  480
ttgtcatca  tgaaaaaaa  aaaaaaaaa  aaaaa  515



<210> 1662
<211> 106
<212> PRT
<213> Homo sapiens
<308> Q9UII2
<400> 1662

Met Ala Val Thr Ala Leu Ala Ala Arg Thr Trp Leu Gly Val Trp Gly 
  1               5                  10                  15
Val Arg Thr Met Gln Ala Arg Gly Phe Gly Ser Asp Gln Ser Glu Asn 
             20                  25                  30
Val Asp Arg Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
         35                  40                  45
Lys Arg Glu Gln Ala Glu Glu Glu Arg Tyr Phe Arg Ala Gln Ser Arg 
     50                  55                  60
Glu Gln Leu Ala Ala Leu Lys Lys His His Glu Glu Glu Ile Val His 
 65                  70                  75                  80
His Lys Lys Glu Ile Glu Arg Leu Gln Lys Glu Ile Glu Arg His Lys 
                 85                  90                  95
Gln Lys Ile Lys Met Leu Lys His Asp Asp 
             100                105



<210> 1663
<211> 481
<212> DNA
<213> Rattus norvegicus
<308> D13122
<400> 1663

caaccacgc  cgcaacgga  ctgagcaac  ccgaagata  tggcaggct  ggcgttggc  60
gttcgggct  ggctcggtg  ctggggtat  agggtcctg  aaacccgag  cttcggctc  120
gactcgtcg  agagcatgg  ttcgggcgc  ggctccatc  gagaagctg  tggggcctt  180
gggaaacga  agaaggctg  agaggatcg  tacttccga  agaagacta  agagcagct  240
gctgccttg  agaagcacc  tgaagatga  attgaccac  attcgaagg  gatagagcg  300
ctgcaaaaa  agatcgaac  gcataagaa  aagattaaa  acctaaaga  tagtgagca  360
tgagtgcac  cagtcagtc  ctcacagag  ggccagtat  attccccac  tctatagag  420
ttgttttga  tgattgatg  ttgacctgt  tgctactaa  agataataa  ttatcacca  480
g  481



<210> 1664
<211> 107
<212> PRT
<213> Rattus norvegicus
<308> Q03344
<400> 1664

Met Ala Gly Ser Ala Leu Ala Val Arg Ala Arg Leu Gly Val Trp Gly 
  1               5                  10                  15
Met Arg Val Leu Gln Thr Arg Gly Phe Gly Ser Asp Ser Ser Glu Ser 
             20                  25                  30
Met Asp Ser Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
         35                  40                  45
Lys Arg Glu Lys Ala Glu Glu Asp Arg Tyr Phe Arg Glu Lys Thr Arg 
     50                  55                  60
Glu Gln Leu Ala Ala Leu Lys Lys His His Glu Asp Glu Ile Asp His 
 65                  70                  75                  80
His Ser Lys Glu Ile Glu Arg Leu Gln Lys Gln Ile Glu Arg His Lys 
                 85                  90                  95
Lys Lys Ile Lys Tyr Leu Lys Asn Ser Glu His 
             100                105



<210> 1665
<211> 515
<212> DNA
<213> Homo sapiens
<308> NM_016311
<400> 1665

cgagagact  cttgctgcg  cagagacgc  agaggtgca  ctccagcag  aatggcagt  60
acggcgttg  cggcgcgga  gtggcttgg  gtgtggggc  tgaggacca  gcaagcccg  120
ggcttcggc  cggatcagt  cgagaatgt  gaccggggc  cgggctcca  ccgggaagc  180
ggtggggcc  tcggaaaga  agagcaggc  gaagaggaa  gatatttcc  agcacagag  240
agagaacaa  tggcagctt  gaaaaaaca  catgaagaa  aaatcgttc  tcataagaa  300
gagattgag  gtctgcaga  agaaattga  cgccataag  agaagatca  aatgctaaa  360
catgatgat  aagtgcaca  cgtgtgcca  agaatggca  atgtcattg  ccacttctg  420
gtagacatg  ttctggttt  actaatatt  gtctgtgtg  tactaacag  ttataataa  480
ttgtcatca  tgaaaaaaa  aaaaaaaaa  aaaaa  515



<210> 1666
<211> 106
<212> PRT
<213> Homo sapiens
<308> Q9UII2
<400> 1666

Met Ala Val Thr Ala Leu Ala Ala Arg Thr Trp Leu Gly Val Trp Gly 
  1               5                  10                  15
Val Arg Thr Met Gln Ala Arg Gly Phe Gly Ser Asp Gln Ser Glu Asn 
             20                  25                  30
Val Asp Arg Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
         35                  40                  45
Lys Arg Glu Gln Ala Glu Glu Glu Arg Tyr Phe Arg Ala Gln Ser Arg 
     50                  55                  60
Glu Gln Leu Ala Ala Leu Lys Lys His His Glu Glu Glu Ile Val His 
 65                  70                  75                  80
His Lys Lys Glu Ile Glu Arg Leu Gln Lys Glu Ile Glu Arg His Lys 
                 85                  90                  95
Gln Lys Ile Lys Met Leu Lys His Asp Asp 
             100                105



<210> 1667
<211> 481
<212> DNA
<213> Rattus norvegicus
<308> D13122
<400> 1667

caaccacgc  cgcaacgga  ctgagcaac  ccgaagata  tggcaggct  ggcgttggc  60
gttcgggct  ggctcggtg  ctggggtat  agggtcctg  aaacccgag  cttcggctc  120
gactcgtcg  agagcatgg  ttcgggcgc  ggctccatc  gagaagctg  tggggcctt  180
gggaaacga  agaaggctg  agaggatcg  tacttccga  agaagacta  agagcagct  240
gctgccttg  agaagcacc  tgaagatga  attgaccac  attcgaagg  gatagagcg  300
ctgcaaaaa  agatcgaac  gcataagaa  aagattaaa  acctaaaga  tagtgagca  360
tgagtgcac  cagtcagtc  ctcacagag  ggccagtat  attccccac  tctatagag  420
ttgttttga  tgattgatg  ttgacctgt  tgctactaa  agataataa  ttatcacca  480
g  481



<210> 1668
<211> 107
<212> PRT
<213> Rattus norvegicus
<308> Q03344
<400> 1668

Met Ala Gly Ser Ala Leu Ala Val Arg Ala Arg Leu Gly Val Trp Gly 
  1               5                  10                  15
Met Arg Val Leu Gln Thr Arg Gly Phe Gly Ser Asp Ser Ser Glu Ser 
             20                  25                  30
Met Asp Ser Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
         35                  40                  45
Lys Arg Glu Lys Ala Glu Glu Asp Arg Tyr Phe Arg Glu Lys Thr Arg 
     50                  55                  60
Glu Gln Leu Ala Ala Leu Lys Lys His His Glu Asp Glu Ile Asp His 
 65                  70                  75                  80
His Ser Lys Glu Ile Glu Arg Leu Gln Lys Gln Ile Glu Arg His Lys 
                 85                  90                  95
Lys Lys Ile Lys Tyr Leu Lys Asn Ser Glu His 
             100                105



<210> 1669
<211> 515
<212> DNA
<213> Homo sapiens
<308> NM_016311
<400> 1669

cgagagact  cttgctgcg  cagagacgc  agaggtgca  ctccagcag  aatggcagt  60
acggcgttg  cggcgcgga  gtggcttgg  gtgtggggc  tgaggacca  gcaagcccg  120
ggcttcggc  cggatcagt  cgagaatgt  gaccggggc  cgggctcca  ccgggaagc  180
ggtggggcc  tcggaaaga  agagcaggc  gaagaggaa  gatatttcc  agcacagag  240
agagaacaa  tggcagctt  gaaaaaaca  catgaagaa  aaatcgttc  tcataagaa  300
gagattgag  gtctgcaga  agaaattga  cgccataag  agaagatca  aatgctaaa  360
catgatgat  aagtgcaca  cgtgtgcca  agaatggca  atgtcattg  ccacttctg  420
gtagacatg  ttctggttt  actaatatt  gtctgtgtg  tactaacag  ttataataa  480
ttgtcatca  tgaaaaaaa  aaaaaaaaa  aaaaa  515



<210> 1670
<211> 106
<212> PRT
<213> Homo sapiens
<308> Q9UII2
<400> 1670

Met Ala Val Thr Ala Leu Ala Ala Arg Thr Trp Leu Gly Val Trp Gly 
  1               5                  10                  15
Val Arg Thr Met Gln Ala Arg Gly Phe Gly Ser Asp Gln Ser Glu Asn 
             20                  25                  30
Val Asp Arg Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
         35                  40                  45
Lys Arg Glu Gln Ala Glu Glu Glu Arg Tyr Phe Arg Ala Gln Ser Arg 
     50                  55                  60
Glu Gln Leu Ala Ala Leu Lys Lys His His Glu Glu Glu Ile Val His 
 65                  70                  75                  80
His Lys Lys Glu Ile Glu Arg Leu Gln Lys Glu Ile Glu Arg His Lys 
                 85                  90                  95
Gln Lys Ile Lys Met Leu Lys His Asp Asp 
             100                105



<210> 1671
<211> 1015
<212> DNA
<213> Rattus norvegicus
<308> D13126
<400> 1671

cgctacacc  cgctctctc  tgggccggc  gatcctttt  tctctccaa  cggtgaagg  60
cgcagagtc  gcgcggcgg  tgcgggcgc  ctgacgccc  ttctattgg  tatctcccc  120
gcctcagcc  ccgccgaac  tgagctcga  aagccagcg  atcgcgtcc  gttccggag  180
cggggcatg  tctagcagc  cagtcaagc  tgtgcatca  ctgatcccc  gcagttctg  240
tcccccttg  cctctactt  gctctaggt  tagtctcca  tgccagctg  catgggcaa  300
cagaacagc  aactgcggc  tgaggtgct  caggacctg  gggaacaca  agagttcac  360
gaccatgag  tgcaggagt  gtataaggg  ttcctcaag  actgtccca  cggccactt  420
acagtggac  aattcaaga  gatctacgc  aacttcttc  cctatggcg  cgcctctaa  480
tttgccgaa  acgtcttcc  cacctttga  accaacagc  atggcacca  cgacttccg  540
gagttcatc  tcgcactga  cgtgacctc  cggggcaag  tggagcaga  gctcaagtg  600
gccttcagc  tgtacgacc  ggacggcaa  ggctacatc  gccgcagtg  aatgctgga  660
attgtgcag  ccatctaca  gatggtgtc  tccgtgatg  agatgcccg  ggatgagtc  720
acacccgag  agcgaacag  caagatctt  aggcagatg  acacaaaca  tgatggcaa  780
ctgtccctg  aagaattca  caaaggtgc  aagagcgac  cgtccattg  ccggttgct  840
cagtgtgac  ccagcagtg  tagccagtt  tgaggggaa  gggcttttg  acagttgtg  900
gaaacacag  cttgacctg  catcttcag  tttgcttgc  aaagtggat  cctccgtga  960
ctctcctgc  ctcccagga  ctgggccag  cagcacatc  cacccaccc  acctg  1015



<210> 1672
<211> 192
<212> PRT
<213> Rattus norvegicus
<308> P35333
<400> 1672

Gly Lys Gln Asn Ser Lys Leu Arg Pro Glu Val Leu Gln Asp Leu Arg 
  1               5                  10                  15
Glu His Thr Glu Phe Thr Asp His Glu Leu Gln Glu Trp Tyr Lys Gly 
             20                  25                  30
Phe Leu Lys Asp Cys Pro Thr Gly His Leu Thr Val Asp Glu Phe Lys 
         35                  40                  45
Lys Ile Tyr Ala Asn Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe Ala 
     50                  55                  60
Glu His Val Phe Arg Thr Phe Asp Thr Asn Ser Asp Gly Thr Ile Asp 
 65                  70                  75                  80
Phe Arg Glu Phe Ile Ile Ala Leu Ser Val Thr Ser Arg Gly Lys Leu 
                 85                  90                  95
Glu Gln Lys Leu Lys Trp Ala Phe Ser Met Tyr Asp Leu Asp Gly Asn 
             100                105                110
Gly Tyr Ile Ser Arg Ser Glu Met Leu Glu Ile Val Gln Ala Ile Tyr 
         115                120                125
Lys Met Val Ser Ser Val Met Lys Met Pro Glu Asp Glu Ser Thr Pro 
     130                135                140
Glu Lys Arg Thr Asp Lys Ile Phe Arg Gln Met Asp Thr Asn Asn Asp 
 145                150                155                160
Gly Lys Leu Ser Leu Glu Glu Phe Ile Lys Gly Ala Lys Ser Asp Pro 
                 165                170                175
Ser Ile Val Arg Leu Leu Gln Cys Asp Pro Ser Ser Ala Ser Gln Phe 
             180                185                190



<210> 1673
<211> 1769
<212> DNA
<213> Homo sapiens
<308> NM_002149
<400> 1673

cggcggcgg  gggcagcgg  cgggcggac  gacgggcgc  tccaccttg  tccctccct  60
gctgccggc  tccttttgt  tttctgggc  gcgatgagc  cagggccgg  gcagcagct  120
cgggcgcac  gaggcccgc  ctgctagtc  ctcctcccg  cctcggcgc  cttgtcccg  180
gcagcggcc  gggcccgct  cagccgccg  cggcgccga  cttgggctc  ggaagccgg  240
ggaccgcgt  ctgcgccgg  gcaggggca  ggtctagtg  cccagtcag  acgcggaaa  300
actccctgg  ggttctgac  cactccctc  cagcctccg  ctggtctct  gtgtagtcg  360
cgccgccag  cgccatggg  aaacagaac  gcaagctgc  gcccgaggt  ctgcaggac  420
tgcgggaga  cacggagtt  accgaccac  agctgcagg  gtggtacaa  ggcttcctc  480
aggactgcc  caccggcca  ctgaccgtg  acgagttca  gaagatcta  gccaacttc  540
tcccctacg  cgacgcttc  aagttcgcc  agcacgtct  ccgcacctt  gacaccaac  600
gcgacggca  catcgactt  cgggagttc  tcattgcgc  gagcgtgac  tcgcggggc  660
agctggagc  gaagctcaa  tgggccttc  gcatgtacg  cctggacgg  aacggctac  720
tcagccgca  cgagatgct  gagatcgtg  aggccatct  caagatggt  tcgtctgtg  780
tgaagatgc  ggaggatga  tccaccccg  agaagcgca  agacaagat  ttcaggcag  840
tggacacca  caatgacgg  aaactgtcc  tggaagaat  catcagagg  gccaagagc  900
acccctcca  cgtccgcct  ctgcagtgc  accccagca  tgccagtca  ttctgagcg  960
gcggcccct  gacagttgc  gagaaacac  ggcttgtcg  gccgtttaa  ctttgcttg  1020
aagagtgga  gccccgcaa  cgttcctgc  ctcccgggc  ccgggcctg  ggcatgcgt  1080
gcacctgcc  ggcccggtg  ctgcgcctc  ctcctccac  tgaccaacg  gacattcct  1140
ccctcacgc  tggcccggt  ccttccagg  caactccca  ggatgtggt  acatgcagg  1200
ttcaagtgt  cttggttcc  ggcacctcc  ggctcacgg  gagctcaga  gtccatgcc  1260
aggagacca  gcaggacct  ccgaggctg  gccccggcc  gcccatgcg  tttgtgatc  1320
caagtgact  tgtgggaag  gtggggacg  ggcgtcggg  gggtataca  ggagcccct  1380
ccgtgcatg  ctgcccccc  gttcatttt  tccaccaca  ccgcttgca  gtatagata  1440
tgtggtccc  tttctttta  tatataaat  atgtatggt  aagtggagt  tattgtgta  1500
gtcccgtat  taatgcctc  gactgcctt  gaagcgcag  cctctgtgg  ccgcagccc  1560
ctgagcctg  ctgttgtgt  gtatttatg  tctctttgt  tgcctgttt  taaggaaat  1620
catgtgtgc  ctgagccgt  atgatcctc  catccgtgt  gtgagcaca  gcatttgtg  1680
ctggtctgt  ctccctgtt  attggtctg  catttccgg  attaaaatg  taaaataaa  1740
ggcattttc  gaaaaaaaa  aaaaaaaaa  1769



<210> 1674
<211> 192
<212> PRT
<213> Homo sapiens
<308> P37235
<400> 1674

Gly Lys Gln Asn Ser Lys Leu Arg Pro Glu Val Leu Gln Asp Leu Arg 
  1               5                  10                  15
Glu Asn Thr Glu Phe Thr Asp His Glu Leu Gln Glu Trp Tyr Lys Gly 
             20                  25                  30
Phe Leu Lys Asp Cys Pro Thr Gly His Leu Thr Val Asp Glu Phe Lys 
         35                  40                  45
Lys Ile Tyr Ala Asn Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe Ala 
     50                  55                  60
Glu His Val Phe Arg Thr Phe Asp Thr Asn Gly Asp Gly Thr Ile Asp 
 65                  70                  75                  80
Phe Arg Glu Phe Ile Ile Ala Leu Ser Val Thr Ser Arg Gly Lys Leu 
                 85                  90                  95
Glu Gln Lys Leu Lys Trp Ala Phe Ser Met Tyr Asp Leu Asp Gly Asn 
             100                105                110
Gly Tyr Ile Ser Arg Ser Glu Met Leu Glu Ile Val Gln Ala Ile Tyr 
         115                120                125
Lys Met Val Ser Ser Val Met Lys Met Pro Glu Asp Glu Ser Thr Pro 
     130                135                140
Glu Lys Arg Thr Asp Lys Ile Phe Arg Gln Met Asp Thr Asn Asn Asp 
 145                150                155                160
Gly Lys Leu Ser Leu Glu Glu Phe Ile Arg Gly Ala Lys Ser Asp Pro 
                 165                170                175
Ser Ile Val Arg Leu Leu Gln Cys Asp Pro Ser Ser Ala Ser Gln Phe 
             180                185                190



<210> 1675
<211> 707
<212> DNA
<213> Rattus norvegicus
<308> D13127
<400> 1675

aaagatggc  gcaccagca  catccgtgc  gtcccgaca  gtgcggagt  tcagcacat  60
tgtggtcag  cccttttcg  agcttgtaa  gccccctgt  caggtctac  gcatcgaag  120
ccgctatgc  accgccctg  actctgctg  gtctaagca  aaaaggctg  accaggtgg  180
aaaggagtt  ctgcgagtg  ggcaactct  gaaggaccc  aaggtgtcc  ttgctgttc  240
gaaccccta  attaagcgc  ccatcaaag  gaaaagcct  aaggacatc  ctacaaagg  300
aaaattctc  ccgctgacg  ccaacctca  gaatttact  gctgaaaat  gtcgcctag  360
caacaccca  ggcgtcatc  ctgccttct  caccatcat  agtgtccac  gtggagaag  420
gccgtgcac  gtgaccaca  cgtttcctt  agatgaagc  gttctctct  agttaaaga  480
agtgctgaa  agcttcctg  gtaaaggcc  gatactgaa  ctggaggtc  agactgacc  540
atcaatcat  ggtgggatg  ttgtccgaa  tggagagaa  tacgttgat  tgtctgcaa  600
gagcaagat  cagaagctc  gcaaggcca  gcgggatct  ctctgagag  ctgtcacct  660
tgtgagcgc  tgtctttgg  gcacaataa  atgcttcct  aacagag  707



<210> 1676
<211> 213
<212> PRT
<213> Rattus norvegicus
<308> Q06647
<400> 1676

Met Ala Ala Pro Ala Thr Ser Val Leu Ser Arg Gln Val Arg Ser Phe 
  1               5                  10                  15
Ser Thr Ser Val Val Arg Pro Phe Ser Lys Leu Val Arg Pro Pro Val 
             20                  25                  30
Gln Val Tyr Gly Ile Glu Gly Arg Tyr Ala Thr Ala Leu Tyr Ser Ala 
         35                  40                  45
Ala Ser Lys Gln Lys Arg Leu Asp Gln Val Glu Lys Glu Leu Leu Arg 
     50                  55                  60
Val Gly Gln Leu Leu Lys Asp Pro Lys Val Ser Leu Ala Val Leu Asn 
 65                  70                  75                  80
Pro Tyr Ile Lys Arg Ser Ile Lys Val Lys Ser Leu Lys Asp Ile Thr 
                 85                  90                  95
Thr Lys Glu Lys Phe Ser Pro Leu Thr Ala Asn Leu Met Asn Leu Leu 
             100                105                110
Ala Glu Asn Gly Arg Leu Gly Asn Thr Gln Gly Val Ile Ser Ala Phe 
         115                120                125
Ser Thr Ile Met Ser Val His Arg Gly Glu Val Pro Cys Thr Val Thr 
     130                135                140
Thr Ala Phe Pro Leu Asp Glu Ala Val Leu Ser Glu Leu Lys Thr Val 
 145                150                155                160
Leu Asn Ser Phe Leu Ser Lys Gly Gln Ile Leu Asn Leu Glu Val Lys 
                 165                170                175
Thr Asp Pro Ser Ile Met Gly Gly Met Ile Val Arg Ile Gly Glu Lys 
             180                185                190
Tyr Val Asp Met Ser Ala Lys Ser Lys Ile Gln Lys Leu Ser Lys Ala 
         195                200                205
Met Arg Asp Leu Leu 
     210



<210> 1677
<211> 386
<212> DNA
<213> Homo sapiens
<308> AW449493
<400> 1677

ttttttttt  tttttttca  gaagcattt  attgttgct  caaggacaa  agctcacac  60
ggtgacagt  tctcagagc  tctcccgca  ggccttgct  agcttctga  tcttgctct  120
tgcagacat  tcaacgtac  tttccccaa  tcggacaat  atcccgccc  tgattgacg  180
gtcagtctt  atctccagt  tcagtattt  gtttggact  aggaagctc  tcagcaccg  240
ctttaactc  gagagaaca  cgtcatcta  aggagatgc  gtggtcact  tgcacggca  300
ttctccgcg  tggacactc  tgatggtgg  aaaggcaga  atgataccc  gggtgttgc  360
taggcgacc  ttttcagca  gtaaat  386



<210> 1678
<211> 213
<212> PRT
<213> Homo sapiens
<308> CAA58219
<400> 1678

Met Ala Ala Pro Ala Val Ser Gly Leu Ser Arg Gln Val Arg Cys Phe 
  1               5                  10                  15
Ser Thr Ser Val Val Arg Pro Phe Ala Lys Leu Val Arg Pro Pro Val 
             20                  25                  30
Gln Val Tyr Gly Ile Glu Gly Arg Tyr Ala Thr Ala Leu Tyr Ser Ala 
         35                  40                  45
Ala Ser Lys Gln Asn Lys Leu Glu Gln Val Glu Lys Glu Leu Leu Arg 
     50                  55                  60
Val Ala Gln Ile Leu Lys Glu Pro Lys Val Ala Ala Ser Val Leu Asn 
 65                  70                  75                  80
Pro Tyr Val Lys Arg Ser Ile Lys Val Lys Ser Leu Asn Asp Ile Thr 
                 85                  90                  95
Ala Lys Glu Arg Phe Ser Pro Leu Thr Thr Asn Leu Ile Asn Leu Leu 
             100                105                110
Ala Glu Asn Gly Arg Leu Ser Asn Thr Gln Gly Val Val Ser Ala Phe 
         115                120                125
Ser Thr Met Met Ser Val His Arg Gly Glu Val Pro Cys Thr Val Thr 
     130                135                140
Ser Ala Ser Pro Leu Glu Glu Ala Thr Leu Ser Glu Leu Lys Thr Val 
 145                150                155                160
Leu Lys Ser Phe Leu Ser Gln Gly Gln Val Leu Lys Leu Glu Ala Lys 
                 165                170                175
Thr Asp Pro Ser Ile Leu Gly Gly Met Ile Val Arg Ile Gly Glu Lys 
             180                185                190
Tyr Val Asp Met Ser Val Lys Thr Lys Ile Gln Lys Leu Gly Arg Ala 
         195                200                205
Met Arg Glu Ile Val 
     210



<210> 1679
<211> 707
<212> DNA
<213> Rattus norvegicus
<308> D13127
<400> 1679

aaagatggc  gcaccagca  catccgtgc  gtcccgaca  gtgcggagt  tcagcacat  60
tgtggtcag  cccttttcg  agcttgtaa  gccccctgt  caggtctac  gcatcgaag  120
ccgctatgc  accgccctg  actctgctg  gtctaagca  aaaaggctg  accaggtgg  180
aaaggagtt  ctgcgagtg  ggcaactct  gaaggaccc  aaggtgtcc  ttgctgttc  240
gaaccccta  attaagcgc  ccatcaaag  gaaaagcct  aaggacatc  ctacaaagg  300
aaaattctc  ccgctgacg  ccaacctca  gaatttact  gctgaaaat  gtcgcctag  360
caacaccca  ggcgtcatc  ctgccttct  caccatcat  agtgtccac  gtggagaag  420
gccgtgcac  gtgaccaca  cgtttcctt  agatgaagc  gttctctct  agttaaaga  480
agtgctgaa  agcttcctg  gtaaaggcc  gatactgaa  ctggaggtc  agactgacc  540
atcaatcat  ggtgggatg  ttgtccgaa  tggagagaa  tacgttgat  tgtctgcaa  600
gagcaagat  cagaagctc  gcaaggcca  gcgggatct  ctctgagag  ctgtcacct  660
tgtgagcgc  tgtctttgg  gcacaataa  atgcttcct  aacagag  707



<210> 1680
<211> 213
<212> PRT
<213> Rattus norvegicus
<308> Q06647
<400> 1680

Met Ala Ala Pro Ala Thr Ser Val Leu Ser Arg Gln Val Arg Ser Phe 
  1               5                  10                  15
Ser Thr Ser Val Val Arg Pro Phe Ser Lys Leu Val Arg Pro Pro Val 
             20                  25                  30
Gln Val Tyr Gly Ile Glu Gly Arg Tyr Ala Thr Ala Leu Tyr Ser Ala 
         35                  40                  45
Ala Ser Lys Gln Lys Arg Leu Asp Gln Val Glu Lys Glu Leu Leu Arg 
     50                  55                  60
Val Gly Gln Leu Leu Lys Asp Pro Lys Val Ser Leu Ala Val Leu Asn 
 65                  70                  75                  80
Pro Tyr Ile Lys Arg Ser Ile Lys Val Lys Ser Leu Lys Asp Ile Thr 
                 85                  90                  95
Thr Lys Glu Lys Phe Ser Pro Leu Thr Ala Asn Leu Met Asn Leu Leu 
             100                105                110
Ala Glu Asn Gly Arg Leu Gly Asn Thr Gln Gly Val Ile Ser Ala Phe 
         115                120                125
Ser Thr Ile Met Ser Val His Arg Gly Glu Val Pro Cys Thr Val Thr 
     130                135                140
Thr Ala Phe Pro Leu Asp Glu Ala Val Leu Ser Glu Leu Lys Thr Val 
 145                150                155                160
Leu Asn Ser Phe Leu Ser Lys Gly Gln Ile Leu Asn Leu Glu Val Lys 
                 165                170                175
Thr Asp Pro Ser Ile Met Gly Gly Met Ile Val Arg Ile Gly Glu Lys 
             180                185                190
Tyr Val Asp Met Ser Ala Lys Ser Lys Ile Gln Lys Leu Ser Lys Ala 
         195                200                205
Met Arg Asp Leu Leu 
     210



<210> 1681
<211> 386
<212> DNA
<213> Homo sapiens
<308> AW449493
<400> 1681

ttttttttt  tttttttca  gaagcattt  attgttgct  caaggacaa  agctcacac  60
ggtgacagt  tctcagagc  tctcccgca  ggccttgct  agcttctga  tcttgctct  120
tgcagacat  tcaacgtac  tttccccaa  tcggacaat  atcccgccc  tgattgacg  180
gtcagtctt  atctccagt  tcagtattt  gtttggact  aggaagctc  tcagcaccg  240
ctttaactc  gagagaaca  cgtcatcta  aggagatgc  gtggtcact  tgcacggca  300
ttctccgcg  tggacactc  tgatggtgg  aaaggcaga  atgataccc  gggtgttgc  360
taggcgacc  ttttcagca  gtaaat  386



<210> 1682
<211> 213
<212> PRT
<213> Homo sapiens
<308> CAA58219
<400> 1682

Met Ala Ala Pro Ala Val Ser Gly Leu Ser Arg Gln Val Arg Cys Phe 
  1               5                  10                  15
Ser Thr Ser Val Val Arg Pro Phe Ala Lys Leu Val Arg Pro Pro Val 
             20                  25                  30
Gln Val Tyr Gly Ile Glu Gly Arg Tyr Ala Thr Ala Leu Tyr Ser Ala 
         35                  40                  45
Ala Ser Lys Gln Asn Lys Leu Glu Gln Val Glu Lys Glu Leu Leu Arg 
     50                  55                  60
Val Ala Gln Ile Leu Lys Glu Pro Lys Val Ala Ala Ser Val Leu Asn 
 65                  70                  75                  80
Pro Tyr Val Lys Arg Ser Ile Lys Val Lys Ser Leu Asn Asp Ile Thr 
                 85                  90                  95
Ala Lys Glu Arg Phe Ser Pro Leu Thr Thr Asn Leu Ile Asn Leu Leu 
             100                105                110
Ala Glu Asn Gly Arg Leu Ser Asn Thr Gln Gly Val Val Ser Ala Phe 
         115                120                125
Ser Thr Met Met Ser Val His Arg Gly Glu Val Pro Cys Thr Val Thr 
     130                135                140
Ser Ala Ser Pro Leu Glu Glu Ala Thr Leu Ser Glu Leu Lys Thr Val 
 145                150                155                160
Leu Lys Ser Phe Leu Ser Gln Gly Gln Val Leu Lys Leu Glu Ala Lys 
                 165                170                175
Thr Asp Pro Ser Ile Leu Gly Gly Met Ile Val Arg Ile Gly Glu Lys 
             180                185                190
Tyr Val Asp Met Ser Val Lys Thr Lys Ile Gln Lys Leu Gly Arg Ala 
         195                200                205
Met Arg Glu Ile Val 
     210



<210> 1683
<211> 1570
<212> DNA
<213> Rattus norvegicus
<308> D13907
<400> 1683

gcggcggct  tatcccgga  gttgttgcc  gtggccgga  ggcgcctgt  gggatttac  60
cgaaggctt  cgctccgcg  cgccgctgc  cagccattg  actttggag  ggaccgact  120
agaagtaca  aggctgctc  acaagttgt  ctgaatgtt  ctgagacac  agtcacttg  180
ttggaaaat  gactcaggg  agcttctga  aactctggg  tctcaacat  caccgttgg  240
ctgtggatc  atgctggca  tcggtatga  aatgaaaag  acaatggca  cgctcactt  300
ctggagcac  tggctttca  gggcactaa  aagaggtcc  agttagacc  tgaacttga  360
attgagaac  tgggtgccc  tctcaatgc  tatacctcc  gagagcaga  tgtctacta  420
gccaaagcc  tctccaaag  tttgccaag  gctgtagaa  ttcttgctg  cataattca  480
aacagtaca  tgagagagg  agagattga  cgtgagcgt  gagtcatcc  cagagaaat  540
caggaagtt  agaccaact  gcaagaagt  gtctttgat  atctgcacg  cacagccta  600
caaaacacc  cgctcggac  gacaattct  ggaccaacc  agaacatca  atctataag  660
cgtaaggac  tagtggact  cataaccac  cattataag  gaccaagaa  cgtgctggc  720
gctgctgga  gtgtttgcc  taacgaact  ctggagtta  cgaagtttc  ttttggtga  780
tctttgtgc  cacacaaag  agatgtacc  gctctgcct  cctgtaaat  cactggaag  840
gagattcgg  tgagggatg  caagatgcc  ctggcgcac  tcgcagtgg  tattgaagc  900
gttggttgg  cgcacccag  cacgatctg  ctcatggtc  caaacacac  gataggcaa  960
tgggaccgc  ctttcggag  aggaatgaa  ttatcgagc  agctggccc  gctcacgtg  1020
catggcaat  tctgccaca  cttccagtc  ttcaacacc  cctacacag  cacaggatt  1080
tgggggctc  atatggttt  tgaacaagc  acagttgct  acatgctgc  cgctgtaca  1140
aaggaatgg  tgcgtctgt  cacagctgt  agtgagagt  aggtcgcac  cgccaaaaa  1200
cttctcaag  caaacatgc  gctgcagct  gatgggtca  ctccgatct  tgaagacat  1260
ggtaggcag  tgctatgct  caacaggag  atccccatc  ctgagcttg  ggccaggat  1320
gatgctgtg  acgcggaga  ggttcgaga  gtgtgcacc  agtacattt  tggcaaaag  1380
ccggccatt  ctgctctcg  tcctattga  cgcttacca  attttaacc  gatttgtag  1440
aacatgcgc  ggactcgtg  ctgattttt  tgatgaatt  tcctacaca  acatattta  1500
aaaactgag  cctagaagt  ttgaaagac  gctcatctt  aagtgaaaa  ataaaaact  1560
tatttgaaac  1570



<210> 1684
<211> 489
<212> PRT
<213> Rattus norvegicus
<308> Q03346
<400> 1684

Met Ala Ala Ala Ala Val Ser Arg Thr Leu Leu Pro Val Ala Gly Arg 
  1               5                  10                  15
Arg Leu Trp Gly Phe Thr Arg Arg Leu Pro Leu Arg Ala Ala Ala Ala 
             20                  25                  30
Gln Pro Leu Tyr Phe Gly Gly Asp Arg Leu Arg Ser Thr Gln Ala Ala 
         35                  40                  45
Pro Gln Val Val Leu Asn Val Pro Glu Thr Gln Val Thr Cys Leu Glu 
     50                  55                  60
Asn Gly Leu Arg Val Ala Ser Glu Asn Ser Gly Ile Ser Thr Cys Thr 
 65                  70                  75                  80
Val Gly Leu Trp Ile Asp Ala Gly Ser Arg Tyr Glu Asn Glu Lys Asn 
                 85                  90                  95
Asn Gly Thr Ala His Phe Leu Glu His Met Ala Phe Lys Gly Thr Lys 
             100                105                110
Lys Arg Ser Gln Leu Asp Leu Glu Leu Glu Ile Glu Asn Met Gly Ala 
         115                120                125
His Leu Asn Ala Tyr Thr Ser Arg Glu Gln Thr Val Tyr Tyr Ala Lys 
     130                135                140
Ala Phe Ser Lys Asp Leu Pro Arg Ala Val Glu Ile Leu Ala Asp Ile 
 145                150                155                160
Ile Gln Asn Ser Thr Leu Gly Glu Ala Glu Ile Glu Arg Glu Arg Gly 
                 165                170                175
Val Ile Leu Arg Glu Met Gln Glu Val Glu Thr Asn Leu Gln Glu Val 
             180                185                190
Val Phe Asp Tyr Leu His Ala Thr Ala Tyr Gln Asn Thr Ala Leu Gly 
         195                200                205
Arg Thr Ile Leu Gly Pro Thr Glu Asn Ile Lys Ser Ile Ser Arg Lys 
     210                215                220
Asp Leu Val Asp Tyr Ile Thr Thr His Tyr Lys Gly Pro Arg Ile Val 
 225                230                235                240
Leu Ala Ala Ala Gly Gly Val Cys His Asn Glu Leu Leu Glu Leu Ala 
                 245                250                255
Lys Phe His Phe Gly Asp Ser Leu Cys Ala His Lys Gly Asp Val Pro 
             260                265                270
Ala Leu Pro Pro Cys Lys Phe Thr Gly Ser Glu Ile Arg Val Arg Asp 
         275                280                285
Asp Lys Met Pro Leu Ala His Leu Ala Val Ala Ile Glu Ala Val Gly 
     290                295                300
Trp Thr His Pro Asp Thr Ile Arg Leu Met Val Ala Asn Thr Leu Ile 
 305                310                315                320
Gly Asn Trp Asp Arg Ser Phe Gly Gly Gly Met Asn Leu Ser Ser Lys 
                 325                330                335
Leu Ala Gln Leu Thr Cys His Gly Asn Leu Cys His Ser Phe Gln Ser 
             340                345                350
Phe Asn Thr Ser Tyr Thr Asp Thr Gly Leu Trp Gly Leu Tyr Met Val 
         355                360                365
Cys Glu Gln Ala Thr Val Ala Asp Met Leu His Ala Val Gln Lys Glu 
     370                375                380
Trp Met Arg Leu Cys Thr Ala Val Ser Glu Ser Glu Val Ala Arg Ala 
 385                390                395                400
Lys Asn Leu Leu Lys Thr Asn Met Leu Leu Gln Leu Asp Gly Ser Thr 
                 405                410                415
Pro Ile Cys Glu Asp Ile Gly Arg Gln Met Leu Cys Tyr Asn Arg Arg 
             420                425                430
Ile Pro Ile Pro Glu Leu Glu Ala Arg Ile Asp Ala Val Asp Ala Glu 
         435                440                445
Met Val Arg Glu Val Cys Thr Lys Tyr Ile Tyr Gly Lys Ser Pro Ala 
     450                455                460
Ile Ala Ala Leu Gly Pro Ile Glu Arg Leu Pro Asp Phe Asn Gln Ile 
 465                470                475                480
Cys Ser Asn Met Arg Trp Thr Arg Asp 
                 485



<210> 1685
<211> 1771
<212> DNA
<213> Homo sapiens
<308> AF054182
<400> 1685

gttcgtagc  gaaatggcg  ctgcggcgg  tcgagtggt  ttgtcatcc  cggcgcgag  60
cggcctctg  ggtttcagc  agagtcttc  aatccgagg  gctgcggga  ggtcattat  120
ttttggaga  aacagatta  gaagtacac  ggctgctac  caagttgtt  tgaatgttc  180
tgaaacaag  gtaacatgt  tagaaagtg  actcagagt  gcttcggaa  actctgggc  240
ctcaacatg  acagttgga  tctggattg  tgctggaag  agatacgaa  atgagaaga  300
caatggaac  gcacacttt  tggagcata  ggctttcaa  ggcaccaag  agagatccc  360
gttagatct  gaacttgag  ttgaaaata  gggtgctca  ctcaatgcc  atacctcca  420
agagcagac  gtatactat  ccaaagcat  ctctaaaga  ttgccaaga  ctgtagaaa  480
tcttgctga  ataatacaa  acagcacat  gggagaagc  gagattgaa  gtgagcgtg  540
agtaatcct  agagagatg  aggaagttg  aaccaattt  caagaagtt  tttttgatt  600
tcttcatgc  acagcttat  aaaatactg  acttggacg  acaattttg  gaccaactg  660
aaatatcaa  tctataagt  gtaaggact  agtggatta  ataaccaca  attataagg  720
gccaagaat  gtgcttgct  ctgctggag  tgtttccca  gatgaattg  ttgacttag  780
aaagtttca  ttcggtgac  ctttatgca  acacaaagg  gaaatacca  ctctgcctc  840
ctgcaaatt  acaggaagt  agattcgtg  gagggatga  aagatgcct  tggcgcacc  900
tgcaatagc  gttgaagct  ttggttggg  acatccaga  acaatctgt  tcatggttg  960
aaacacgct  attggcaac  gggatcgct  ttttggggg  ggaatgaat  tatctagca  1020
gctggccca  ctcacttgt  atggcaatc  ttgccatag  tttcagtct  tcaacactt  1080
ctacacaga  acaggatta  ggggactgt  tatggtttg  gaatcatcc  ctgttgcag  1140
catgctaca  gttgttcaa  aagaatgga  gcgactctg  acaagtgtc  cagaaagtg  1200
ggttgcacg  gccagaaat  ttctgaaaa  aaacatgtt  ttgcagctt  atggttcaa  1260
tccaatttg  gaagatatt  gtaggcaaa  gttatgcta  aatagaagg  ttcccatcc  1320
tgagcttga  gcaagaatt  atgctgtga  tgctgagac  attcgagaa  tatgtacca  1380
atacattta  aataggagt  cagctattg  tgctgttgg  cccattaag  aactaccag  1440
ttttaaaca  atacgcagt  acatgtgtt  gcttcgtga  taaaatgct  ctaatcaag  1500
ttgtttgaa  acatgtatt  ataaaacag  gctagagaa  aataaaaat  aacatgtat  1560
tacatttgg  aatttgaat  aaatactgt  tcatacttt  aaaggataa  aagactacc  1620
ctctgaagg  tgttttgta  taatggtca  tctttgttc  ctgagaaat  atgttggaa  1680
cagcatact  tcaaattat  accatgagt  taattttaa  aatgaaaat  tttacagta  1740
tttcagttt  attataaaa  tgcacacac  a  1771



<210> 1686
<211> 489
<212> PRT
<213> Homo sapiens
<308> O75439
<400> 1686

Met Ala Ala Ala Ala Ala Arg Val Val Leu Ser Ser Ala Ala Arg Gly 
  1               5                  10                  15
Gly Leu Trp Gly Phe Ser Glu Ser Leu Leu Ile Arg Gly Ala Ala Gly 
             20                  25                  30
Arg Ser Leu Tyr Phe Gly Glu Asn Arg Leu Arg Ser Thr Gln Ala Ala 
         35                  40                  45
Thr Gln Val Val Leu Asn Val Pro Glu Thr Arg Val Thr Cys Leu Glu 
     50                  55                  60
Ser Gly Leu Arg Val Ala Ser Glu Asp Ser Gly Leu Ser Thr Cys Thr 
 65                  70                  75                  80
Val Gly Leu Trp Ile Asp Ala Gly Ser Arg Tyr Glu Asn Glu Lys Asn 
                 85                  90                  95
Asn Gly Thr Ala His Phe Leu Glu His Met Ala Phe Lys Gly Thr Lys 
             100                105                110
Lys Arg Ser Gln Leu Asp Leu Glu Leu Glu Ile Glu Asn Met Gly Ala 
         115                120                125
His Leu Asn Ala Tyr Thr Ser Arg Glu Gln Thr Val Tyr Tyr Ala Lys 
     130                135                140
Ala Phe Ser Lys Asp Leu Pro Arg Ala Val Glu Ile Leu Ala Asp Ile 
 145                150                155                160
Ile Gln Asn Ser Thr Leu Gly Glu Ala Glu Ile Glu Arg Glu Arg Gly 
                 165                170                175
Val Ile Leu Arg Glu Met Gln Glu Val Glu Thr Asn Leu Gln Glu Val 
             180                185                190
Val Phe Asp Tyr Leu His Ala Thr Ala Tyr Gln Asn Thr Ala Leu Gly 
         195                200                205
Arg Thr Ile Leu Gly Pro Thr Glu Asn Ile Lys Ser Ile Ser Arg Lys 
     210                215                220
Asp Leu Val Asp Tyr Ile Thr Thr His Tyr Lys Gly Pro Arg Ile Val 
 225                230                235                240
Leu Ala Ala Ala Gly Gly Val Ser His Asp Glu Leu Leu Asp Leu Ala 
                 245                250                255
Lys Phe His Phe Gly Asp Ser Leu Cys Thr His Lys Gly Glu Ile Pro 
             260                265                270
Ala Leu Pro Pro Cys Lys Phe Thr Gly Ser Glu Ile Arg Val Arg Asp 
         275                280                285
Asp Lys Met Pro Leu Ala His Leu Ala Ile Ala Val Glu Ala Val Gly 
     290                295                300
Trp Ala His Pro Asp Thr Ile Cys Leu Met Val Ala Asn Thr Leu Ile 
 305                310                315                320
Gly Asn Trp Asp Arg Ser Phe Gly Gly Gly Met Asn Leu Ser Ser Lys 
                 325                330                335
Leu Ala Gln Leu Thr Cys His Gly Asn Leu Cys His Ser Phe Gln Ser 
             340                345                350
Phe Asn Thr Ser Tyr Thr Asp Thr Gly Leu Trp Gly Leu Tyr Met Val 
         355                360                365
Cys Glu Ser Ser Thr Val Ala Asp Met Leu His Val Val Gln Lys Glu 
     370                375                380
Trp Met Arg Leu Cys Thr Ser Val Thr Glu Ser Glu Val Ala Arg Ala 
 385                390                395                400
Arg Asn Leu Leu Lys Thr Asn Met Leu Leu Gln Leu Asp Gly Ser Thr 
                 405                410                415
Pro Ile Cys Glu Asp Ile Gly Arg Gln Met Leu Cys Tyr Asn Arg Arg 
             420                425                430
Ile Pro Ile Pro Glu Leu Glu Ala Arg Ile Asp Ala Val Asn Ala Glu 
         435                440                445
Thr Ile Arg Glu Val Cys Thr Lys Tyr Ile Tyr Asn Arg Ser Pro Ala 
     450                455                460
Ile Ala Ala Val Gly Pro Ile Lys Gln Leu Pro Asp Phe Lys Gln Ile 
 465                470                475                480
Arg Ser Asn Met Cys Trp Leu Arg Asp 
                 485



<210> 1687
<211> 1570
<212> DNA
<213> Rattus norvegicus
<308> D13907
<400> 1687

gcggcggct  tatcccgga  gttgttgcc  gtggccgga  ggcgcctgt  gggatttac  60
cgaaggctt  cgctccgcg  cgccgctgc  cagccattg  actttggag  ggaccgact  120
agaagtaca  aggctgctc  acaagttgt  ctgaatgtt  ctgagacac  agtcacttg  180
ttggaaaat  gactcaggg  agcttctga  aactctggg  tctcaacat  caccgttgg  240
ctgtggatc  atgctggca  tcggtatga  aatgaaaag  acaatggca  cgctcactt  300
ctggagcac  tggctttca  gggcactaa  aagaggtcc  agttagacc  tgaacttga  360
attgagaac  tgggtgccc  tctcaatgc  tatacctcc  gagagcaga  tgtctacta  420
gccaaagcc  tctccaaag  tttgccaag  gctgtagaa  ttcttgctg  cataattca  480
aacagtaca  tgagagagg  agagattga  cgtgagcgt  gagtcatcc  cagagaaat  540
caggaagtt  agaccaact  gcaagaagt  gtctttgat  atctgcacg  cacagccta  600
caaaacacc  cgctcggac  gacaattct  ggaccaacc  agaacatca  atctataag  660
cgtaaggac  tagtggact  cataaccac  cattataag  gaccaagaa  cgtgctggc  720
gctgctgga  gtgtttgcc  taacgaact  ctggagtta  cgaagtttc  ttttggtga  780
tctttgtgc  cacacaaag  agatgtacc  gctctgcct  cctgtaaat  cactggaag  840
gagattcgg  tgagggatg  caagatgcc  ctggcgcac  tcgcagtgg  tattgaagc  900
gttggttgg  cgcacccag  cacgatctg  ctcatggtc  caaacacac  gataggcaa  960
tgggaccgc  ctttcggag  aggaatgaa  ttatcgagc  agctggccc  gctcacgtg  1020
catggcaat  tctgccaca  cttccagtc  ttcaacacc  cctacacag  cacaggatt  1080
tgggggctc  atatggttt  tgaacaagc  acagttgct  acatgctgc  cgctgtaca  1140
aaggaatgg  tgcgtctgt  cacagctgt  agtgagagt  aggtcgcac  cgccaaaaa  1200
cttctcaag  caaacatgc  gctgcagct  gatgggtca  ctccgatct  tgaagacat  1260
ggtaggcag  tgctatgct  caacaggag  atccccatc  ctgagcttg  ggccaggat  1320
gatgctgtg  acgcggaga  ggttcgaga  gtgtgcacc  agtacattt  tggcaaaag  1380
ccggccatt  ctgctctcg  tcctattga  cgcttacca  attttaacc  gatttgtag  1440
aacatgcgc  ggactcgtg  ctgattttt  tgatgaatt  tcctacaca  acatattta  1500
aaaactgag  cctagaagt  ttgaaagac  gctcatctt  aagtgaaaa  ataaaaact  1560
tatttgaaac  1570



<210> 1688
<211> 489
<212> PRT
<213> Rattus norvegicus
<308> Q03346
<400> 1688

Met Ala Ala Ala Ala Val Ser Arg Thr Leu Leu Pro Val Ala Gly Arg 
  1               5                  10                  15
Arg Leu Trp Gly Phe Thr Arg Arg Leu Pro Leu Arg Ala Ala Ala Ala 
             20                  25                  30
Gln Pro Leu Tyr Phe Gly Gly Asp Arg Leu Arg Ser Thr Gln Ala Ala 
         35                  40                  45
Pro Gln Val Val Leu Asn Val Pro Glu Thr Gln Val Thr Cys Leu Glu 
     50                  55                  60
Asn Gly Leu Arg Val Ala Ser Glu Asn Ser Gly Ile Ser Thr Cys Thr 
 65                  70                  75                  80
Val Gly Leu Trp Ile Asp Ala Gly Ser Arg Tyr Glu Asn Glu Lys Asn 
                 85                  90                  95
Asn Gly Thr Ala His Phe Leu Glu His Met Ala Phe Lys Gly Thr Lys 
             100                105                110
Lys Arg Ser Gln Leu Asp Leu Glu Leu Glu Ile Glu Asn Met Gly Ala 
         115                120                125
His Leu Asn Ala Tyr Thr Ser Arg Glu Gln Thr Val Tyr Tyr Ala Lys 
     130                135                140
Ala Phe Ser Lys Asp Leu Pro Arg Ala Val Glu Ile Leu Ala Asp Ile 
 145                150                155                160
Ile Gln Asn Ser Thr Leu Gly Glu Ala Glu Ile Glu Arg Glu Arg Gly 
                 165                170                175
Val Ile Leu Arg Glu Met Gln Glu Val Glu Thr Asn Leu Gln Glu Val 
             180                185                190
Val Phe Asp Tyr Leu His Ala Thr Ala Tyr Gln Asn Thr Ala Leu Gly 
         195                200                205
Arg Thr Ile Leu Gly Pro Thr Glu Asn Ile Lys Ser Ile Ser Arg Lys 
     210                215                220
Asp Leu Val Asp Tyr Ile Thr Thr His Tyr Lys Gly Pro Arg Ile Val 
 225                230                235                240
Leu Ala Ala Ala Gly Gly Val Cys His Asn Glu Leu Leu Glu Leu Ala 
                 245                250                255
Lys Phe His Phe Gly Asp Ser Leu Cys Ala His Lys Gly Asp Val Pro 
             260                265                270
Ala Leu Pro Pro Cys Lys Phe Thr Gly Ser Glu Ile Arg Val Arg Asp 
         275                280                285
Asp Lys Met Pro Leu Ala His Leu Ala Val Ala Ile Glu Ala Val Gly 
     290                295                300
Trp Thr His Pro Asp Thr Ile Arg Leu Met Val Ala Asn Thr Leu Ile 
 305                310                315                320
Gly Asn Trp Asp Arg Ser Phe Gly Gly Gly Met Asn Leu Ser Ser Lys 
                 325                330                335
Leu Ala Gln Leu Thr Cys His Gly Asn Leu Cys His Ser Phe Gln Ser 
             340                345                350
Phe Asn Thr Ser Tyr Thr Asp Thr Gly Leu Trp Gly Leu Tyr Met Val 
         355                360                365
Cys Glu Gln Ala Thr Val Ala Asp Met Leu His Ala Val Gln Lys Glu 
     370                375                380
Trp Met Arg Leu Cys Thr Ala Val Ser Glu Ser Glu Val Ala Arg Ala 
 385                390                395                400
Lys Asn Leu Leu Lys Thr Asn Met Leu Leu Gln Leu Asp Gly Ser Thr 
                 405                410                415
Pro Ile Cys Glu Asp Ile Gly Arg Gln Met Leu Cys Tyr Asn Arg Arg 
             420                425                430
Ile Pro Ile Pro Glu Leu Glu Ala Arg Ile Asp Ala Val Asp Ala Glu 
         435                440                445
Met Val Arg Glu Val Cys Thr Lys Tyr Ile Tyr Gly Lys Ser Pro Ala 
     450                455                460
Ile Ala Ala Leu Gly Pro Ile Glu Arg Leu Pro Asp Phe Asn Gln Ile 
 465                470                475                480
Cys Ser Asn Met Arg Trp Thr Arg Asp 
                 485



<210> 1689
<211> 1771
<212> DNA
<213> Homo sapiens
<308> AF054182
<400> 1689

gttcgtagc  gaaatggcg  ctgcggcgg  tcgagtggt  ttgtcatcc  cggcgcgag  60
cggcctctg  ggtttcagc  agagtcttc  aatccgagg  gctgcggga  ggtcattat  120
ttttggaga  aacagatta  gaagtacac  ggctgctac  caagttgtt  tgaatgttc  180
tgaaacaag  gtaacatgt  tagaaagtg  actcagagt  gcttcggaa  actctgggc  240
ctcaacatg  acagttgga  tctggattg  tgctggaag  agatacgaa  atgagaaga  300
caatggaac  gcacacttt  tggagcata  ggctttcaa  ggcaccaag  agagatccc  360
gttagatct  gaacttgag  ttgaaaata  gggtgctca  ctcaatgcc  atacctcca  420
agagcagac  gtatactat  ccaaagcat  ctctaaaga  ttgccaaga  ctgtagaaa  480
tcttgctga  ataatacaa  acagcacat  gggagaagc  gagattgaa  gtgagcgtg  540
agtaatcct  agagagatg  aggaagttg  aaccaattt  caagaagtt  tttttgatt  600
tcttcatgc  acagcttat  aaaatactg  acttggacg  acaattttg  gaccaactg  660
aaatatcaa  tctataagt  gtaaggact  agtggatta  ataaccaca  attataagg  720
gccaagaat  gtgcttgct  ctgctggag  tgtttccca  gatgaattg  ttgacttag  780
aaagtttca  ttcggtgac  ctttatgca  acacaaagg  gaaatacca  ctctgcctc  840
ctgcaaatt  acaggaagt  agattcgtg  gagggatga  aagatgcct  tggcgcacc  900
tgcaatagc  gttgaagct  ttggttggg  acatccaga  acaatctgt  tcatggttg  960
aaacacgct  attggcaac  gggatcgct  ttttggggg  ggaatgaat  tatctagca  1020
gctggccca  ctcacttgt  atggcaatc  ttgccatag  tttcagtct  tcaacactt  1080
ctacacaga  acaggatta  ggggactgt  tatggtttg  gaatcatcc  ctgttgcag  1140
catgctaca  gttgttcaa  aagaatgga  gcgactctg  acaagtgtc  cagaaagtg  1200
ggttgcacg  gccagaaat  ttctgaaaa  aaacatgtt  ttgcagctt  atggttcaa  1260
tccaatttg  gaagatatt  gtaggcaaa  gttatgcta  aatagaagg  ttcccatcc  1320
tgagcttga  gcaagaatt  atgctgtga  tgctgagac  attcgagaa  tatgtacca  1380
atacattta  aataggagt  cagctattg  tgctgttgg  cccattaag  aactaccag  1440
ttttaaaca  atacgcagt  acatgtgtt  gcttcgtga  taaaatgct  ctaatcaag  1500
ttgtttgaa  acatgtatt  ataaaacag  gctagagaa  aataaaaat  aacatgtat  1560
tacatttgg  aatttgaat  aaatactgt  tcatacttt  aaaggataa  aagactacc  1620
ctctgaagg  tgttttgta  taatggtca  tctttgttc  ctgagaaat  atgttggaa  1680
cagcatact  tcaaattat  accatgagt  taattttaa  aatgaaaat  tttacagta  1740
tttcagttt  attataaaa  tgcacacac  a  1771



<210> 1690
<211> 489
<212> PRT
<213> Homo sapiens
<308> O75439
<400> 1690

Met Ala Ala Ala Ala Ala Arg Val Val Leu Ser Ser Ala Ala Arg Gly 
  1               5                  10                  15
Gly Leu Trp Gly Phe Ser Glu Ser Leu Leu Ile Arg Gly Ala Ala Gly 
             20                  25                  30
Arg Ser Leu Tyr Phe Gly Glu Asn Arg Leu Arg Ser Thr Gln Ala Ala 
         35                  40                  45
Thr Gln Val Val Leu Asn Val Pro Glu Thr Arg Val Thr Cys Leu Glu 
     50                  55                  60
Ser Gly Leu Arg Val Ala Ser Glu Asp Ser Gly Leu Ser Thr Cys Thr 
 65                  70                  75                  80
Val Gly Leu Trp Ile Asp Ala Gly Ser Arg Tyr Glu Asn Glu Lys Asn 
                 85                  90                  95
Asn Gly Thr Ala His Phe Leu Glu His Met Ala Phe Lys Gly Thr Lys 
             100                105                110
Lys Arg Ser Gln Leu Asp Leu Glu Leu Glu Ile Glu Asn Met Gly Ala 
         115                120                125
His Leu Asn Ala Tyr Thr Ser Arg Glu Gln Thr Val Tyr Tyr Ala Lys 
     130                135                140
Ala Phe Ser Lys Asp Leu Pro Arg Ala Val Glu Ile Leu Ala Asp Ile 
 145                150                155                160
Ile Gln Asn Ser Thr Leu Gly Glu Ala Glu Ile Glu Arg Glu Arg Gly 
                 165                170                175
Val Ile Leu Arg Glu Met Gln Glu Val Glu Thr Asn Leu Gln Glu Val 
             180                185                190
Val Phe Asp Tyr Leu His Ala Thr Ala Tyr Gln Asn Thr Ala Leu Gly 
         195                200                205
Arg Thr Ile Leu Gly Pro Thr Glu Asn Ile Lys Ser Ile Ser Arg Lys 
     210                215                220
Asp Leu Val Asp Tyr Ile Thr Thr His Tyr Lys Gly Pro Arg Ile Val 
 225                230                235                240
Leu Ala Ala Ala Gly Gly Val Ser His Asp Glu Leu Leu Asp Leu Ala 
                 245                250                255
Lys Phe His Phe Gly Asp Ser Leu Cys Thr His Lys Gly Glu Ile Pro 
             260                265                270
Ala Leu Pro Pro Cys Lys Phe Thr Gly Ser Glu Ile Arg Val Arg Asp 
         275                280                285
Asp Lys Met Pro Leu Ala His Leu Ala Ile Ala Val Glu Ala Val Gly 
     290                295                300
Trp Ala His Pro Asp Thr Ile Cys Leu Met Val Ala Asn Thr Leu Ile 
 305                310                315                320
Gly Asn Trp Asp Arg Ser Phe Gly Gly Gly Met Asn Leu Ser Ser Lys 
                 325                330                335
Leu Ala Gln Leu Thr Cys His Gly Asn Leu Cys His Ser Phe Gln Ser 
             340                345                350
Phe Asn Thr Ser Tyr Thr Asp Thr Gly Leu Trp Gly Leu Tyr Met Val 
         355                360                365
Cys Glu Ser Ser Thr Val Ala Asp Met Leu His Val Val Gln Lys Glu 
     370                375                380
Trp Met Arg Leu Cys Thr Ser Val Thr Glu Ser Glu Val Ala Arg Ala 
 385                390                395                400
Arg Asn Leu Leu Lys Thr Asn Met Leu Leu Gln Leu Asp Gly Ser Thr 
                 405                410                415
Pro Ile Cys Glu Asp Ile Gly Arg Gln Met Leu Cys Tyr Asn Arg Arg 
             420                425                430
Ile Pro Ile Pro Glu Leu Glu Ala Arg Ile Asp Ala Val Asn Ala Glu 
         435                440                445
Thr Ile Arg Glu Val Cys Thr Lys Tyr Ile Tyr Asn Arg Ser Pro Ala 
     450                455                460
Ile Ala Ala Val Gly Pro Ile Lys Gln Leu Pro Asp Phe Lys Gln Ile 
 465                470                475                480
Arg Ser Asn Met Cys Trp Leu Arg Asp 
                 485



<210> 1691
<211> 1570
<212> DNA
<213> Rattus norvegicus
<308> D13907
<400> 1691

gcggcggct  tatcccgga  gttgttgcc  gtggccgga  ggcgcctgt  gggatttac  60
cgaaggctt  cgctccgcg  cgccgctgc  cagccattg  actttggag  ggaccgact  120
agaagtaca  aggctgctc  acaagttgt  ctgaatgtt  ctgagacac  agtcacttg  180
ttggaaaat  gactcaggg  agcttctga  aactctggg  tctcaacat  caccgttgg  240
ctgtggatc  atgctggca  tcggtatga  aatgaaaag  acaatggca  cgctcactt  300
ctggagcac  tggctttca  gggcactaa  aagaggtcc  agttagacc  tgaacttga  360
attgagaac  tgggtgccc  tctcaatgc  tatacctcc  gagagcaga  tgtctacta  420
gccaaagcc  tctccaaag  tttgccaag  gctgtagaa  ttcttgctg  cataattca  480
aacagtaca  tgagagagg  agagattga  cgtgagcgt  gagtcatcc  cagagaaat  540
caggaagtt  agaccaact  gcaagaagt  gtctttgat  atctgcacg  cacagccta  600
caaaacacc  cgctcggac  gacaattct  ggaccaacc  agaacatca  atctataag  660
cgtaaggac  tagtggact  cataaccac  cattataag  gaccaagaa  cgtgctggc  720
gctgctgga  gtgtttgcc  taacgaact  ctggagtta  cgaagtttc  ttttggtga  780
tctttgtgc  cacacaaag  agatgtacc  gctctgcct  cctgtaaat  cactggaag  840
gagattcgg  tgagggatg  caagatgcc  ctggcgcac  tcgcagtgg  tattgaagc  900
gttggttgg  cgcacccag  cacgatctg  ctcatggtc  caaacacac  gataggcaa  960
tgggaccgc  ctttcggag  aggaatgaa  ttatcgagc  agctggccc  gctcacgtg  1020
catggcaat  tctgccaca  cttccagtc  ttcaacacc  cctacacag  cacaggatt  1080
tgggggctc  atatggttt  tgaacaagc  acagttgct  acatgctgc  cgctgtaca  1140
aaggaatgg  tgcgtctgt  cacagctgt  agtgagagt  aggtcgcac  cgccaaaaa  1200
cttctcaag  caaacatgc  gctgcagct  gatgggtca  ctccgatct  tgaagacat  1260
ggtaggcag  tgctatgct  caacaggag  atccccatc  ctgagcttg  ggccaggat  1320
gatgctgtg  acgcggaga  ggttcgaga  gtgtgcacc  agtacattt  tggcaaaag  1380
ccggccatt  ctgctctcg  tcctattga  cgcttacca  attttaacc  gatttgtag  1440
aacatgcgc  ggactcgtg  ctgattttt  tgatgaatt  tcctacaca  acatattta  1500
aaaactgag  cctagaagt  ttgaaagac  gctcatctt  aagtgaaaa  ataaaaact  1560
tatttgaaac  1570



<210> 1692
<211> 489
<212> PRT
<213> Rattus norvegicus
<308> Q03346
<400> 1692

Met Ala Ala Ala Ala Val Ser Arg Thr Leu Leu Pro Val Ala Gly Arg 
  1               5                  10                  15
Arg Leu Trp Gly Phe Thr Arg Arg Leu Pro Leu Arg Ala Ala Ala Ala 
             20                  25                  30
Gln Pro Leu Tyr Phe Gly Gly Asp Arg Leu Arg Ser Thr Gln Ala Ala 
         35                  40                  45
Pro Gln Val Val Leu Asn Val Pro Glu Thr Gln Val Thr Cys Leu Glu 
     50                  55                  60
Asn Gly Leu Arg Val Ala Ser Glu Asn Ser Gly Ile Ser Thr Cys Thr 
 65                  70                  75                  80
Val Gly Leu Trp Ile Asp Ala Gly Ser Arg Tyr Glu Asn Glu Lys Asn 
                 85                  90                  95
Asn Gly Thr Ala His Phe Leu Glu His Met Ala Phe Lys Gly Thr Lys 
             100                105                110
Lys Arg Ser Gln Leu Asp Leu Glu Leu Glu Ile Glu Asn Met Gly Ala 
         115                120                125
His Leu Asn Ala Tyr Thr Ser Arg Glu Gln Thr Val Tyr Tyr Ala Lys 
     130                135                140
Ala Phe Ser Lys Asp Leu Pro Arg Ala Val Glu Ile Leu Ala Asp Ile 
 145                150                155                160
Ile Gln Asn Ser Thr Leu Gly Glu Ala Glu Ile Glu Arg Glu Arg Gly 
                 165                170                175
Val Ile Leu Arg Glu Met Gln Glu Val Glu Thr Asn Leu Gln Glu Val 
             180                185                190
Val Phe Asp Tyr Leu His Ala Thr Ala Tyr Gln Asn Thr Ala Leu Gly 
         195                200                205
Arg Thr Ile Leu Gly Pro Thr Glu Asn Ile Lys Ser Ile Ser Arg Lys 
     210                215                220
Asp Leu Val Asp Tyr Ile Thr Thr His Tyr Lys Gly Pro Arg Ile Val 
 225                230                235                240
Leu Ala Ala Ala Gly Gly Val Cys His Asn Glu Leu Leu Glu Leu Ala 
                 245                250                255
Lys Phe His Phe Gly Asp Ser Leu Cys Ala His Lys Gly Asp Val Pro 
             260                265                270
Ala Leu Pro Pro Cys Lys Phe Thr Gly Ser Glu Ile Arg Val Arg Asp 
         275                280                285
Asp Lys Met Pro Leu Ala His Leu Ala Val Ala Ile Glu Ala Val Gly 
     290                295                300
Trp Thr His Pro Asp Thr Ile Arg Leu Met Val Ala Asn Thr Leu Ile 
 305                310                315                320
Gly Asn Trp Asp Arg Ser Phe Gly Gly Gly Met Asn Leu Ser Ser Lys 
                 325                330                335
Leu Ala Gln Leu Thr Cys His Gly Asn Leu Cys His Ser Phe Gln Ser 
             340                345                350
Phe Asn Thr Ser Tyr Thr Asp Thr Gly Leu Trp Gly Leu Tyr Met Val 
         355                360                365
Cys Glu Gln Ala Thr Val Ala Asp Met Leu His Ala Val Gln Lys Glu 
     370                375                380
Trp Met Arg Leu Cys Thr Ala Val Ser Glu Ser Glu Val Ala Arg Ala 
 385                390                395                400
Lys Asn Leu Leu Lys Thr Asn Met Leu Leu Gln Leu Asp Gly Ser Thr 
                 405                410                415
Pro Ile Cys Glu Asp Ile Gly Arg Gln Met Leu Cys Tyr Asn Arg Arg 
             420                425                430
Ile Pro Ile Pro Glu Leu Glu Ala Arg Ile Asp Ala Val Asp Ala Glu 
         435                440                445
Met Val Arg Glu Val Cys Thr Lys Tyr Ile Tyr Gly Lys Ser Pro Ala 
     450                455                460
Ile Ala Ala Leu Gly Pro Ile Glu Arg Leu Pro Asp Phe Asn Gln Ile 
 465                470                475                480
Cys Ser Asn Met Arg Trp Thr Arg Asp 
                 485



<210> 1693
<211> 1771
<212> DNA
<213> Homo sapiens
<308> AF054182
<400> 1693

gttcgtagc  gaaatggcg  ctgcggcgg  tcgagtggt  ttgtcatcc  cggcgcgag  60
cggcctctg  ggtttcagc  agagtcttc  aatccgagg  gctgcggga  ggtcattat  120
ttttggaga  aacagatta  gaagtacac  ggctgctac  caagttgtt  tgaatgttc  180
tgaaacaag  gtaacatgt  tagaaagtg  actcagagt  gcttcggaa  actctgggc  240
ctcaacatg  acagttgga  tctggattg  tgctggaag  agatacgaa  atgagaaga  300
caatggaac  gcacacttt  tggagcata  ggctttcaa  ggcaccaag  agagatccc  360
gttagatct  gaacttgag  ttgaaaata  gggtgctca  ctcaatgcc  atacctcca  420
agagcagac  gtatactat  ccaaagcat  ctctaaaga  ttgccaaga  ctgtagaaa  480
tcttgctga  ataatacaa  acagcacat  gggagaagc  gagattgaa  gtgagcgtg  540
agtaatcct  agagagatg  aggaagttg  aaccaattt  caagaagtt  tttttgatt  600
tcttcatgc  acagcttat  aaaatactg  acttggacg  acaattttg  gaccaactg  660
aaatatcaa  tctataagt  gtaaggact  agtggatta  ataaccaca  attataagg  720
gccaagaat  gtgcttgct  ctgctggag  tgtttccca  gatgaattg  ttgacttag  780
aaagtttca  ttcggtgac  ctttatgca  acacaaagg  gaaatacca  ctctgcctc  840
ctgcaaatt  acaggaagt  agattcgtg  gagggatga  aagatgcct  tggcgcacc  900
tgcaatagc  gttgaagct  ttggttggg  acatccaga  acaatctgt  tcatggttg  960
aaacacgct  attggcaac  gggatcgct  ttttggggg  ggaatgaat  tatctagca  1020
gctggccca  ctcacttgt  atggcaatc  ttgccatag  tttcagtct  tcaacactt  1080
ctacacaga  acaggatta  ggggactgt  tatggtttg  gaatcatcc  ctgttgcag  1140
catgctaca  gttgttcaa  aagaatgga  gcgactctg  acaagtgtc  cagaaagtg  1200
ggttgcacg  gccagaaat  ttctgaaaa  aaacatgtt  ttgcagctt  atggttcaa  1260
tccaatttg  gaagatatt  gtaggcaaa  gttatgcta  aatagaagg  ttcccatcc  1320
tgagcttga  gcaagaatt  atgctgtga  tgctgagac  attcgagaa  tatgtacca  1380
atacattta  aataggagt  cagctattg  tgctgttgg  cccattaag  aactaccag  1440
ttttaaaca  atacgcagt  acatgtgtt  gcttcgtga  taaaatgct  ctaatcaag  1500
ttgtttgaa  acatgtatt  ataaaacag  gctagagaa  aataaaaat  aacatgtat  1560
tacatttgg  aatttgaat  aaatactgt  tcatacttt  aaaggataa  aagactacc  1620
ctctgaagg  tgttttgta  taatggtca  tctttgttc  ctgagaaat  atgttggaa  1680
cagcatact  tcaaattat  accatgagt  taattttaa  aatgaaaat  tttacagta  1740
tttcagttt  attataaaa  tgcacacac  a  1771



<210> 1694
<211> 489
<212> PRT
<213> Homo sapiens
<308> O75439
<400> 1694

Met Ala Ala Ala Ala Ala Arg Val Val Leu Ser Ser Ala Ala Arg Gly 
  1               5                  10                  15
Gly Leu Trp Gly Phe Ser Glu Ser Leu Leu Ile Arg Gly Ala Ala Gly 
             20                  25                  30
Arg Ser Leu Tyr Phe Gly Glu Asn Arg Leu Arg Ser Thr Gln Ala Ala 
         35                  40                  45
Thr Gln Val Val Leu Asn Val Pro Glu Thr Arg Val Thr Cys Leu Glu 
     50                  55                  60
Ser Gly Leu Arg Val Ala Ser Glu Asp Ser Gly Leu Ser Thr Cys Thr 
 65                  70                  75                  80
Val Gly Leu Trp Ile Asp Ala Gly Ser Arg Tyr Glu Asn Glu Lys Asn 
                 85                  90                  95
Asn Gly Thr Ala His Phe Leu Glu His Met Ala Phe Lys Gly Thr Lys 
             100                105                110
Lys Arg Ser Gln Leu Asp Leu Glu Leu Glu Ile Glu Asn Met Gly Ala 
         115                120                125
His Leu Asn Ala Tyr Thr Ser Arg Glu Gln Thr Val Tyr Tyr Ala Lys 
     130                135                140
Ala Phe Ser Lys Asp Leu Pro Arg Ala Val Glu Ile Leu Ala Asp Ile 
 145                150                155                160
Ile Gln Asn Ser Thr Leu Gly Glu Ala Glu Ile Glu Arg Glu Arg Gly 
                 165                170                175
Val Ile Leu Arg Glu Met Gln Glu Val Glu Thr Asn Leu Gln Glu Val 
             180                185                190
Val Phe Asp Tyr Leu His Ala Thr Ala Tyr Gln Asn Thr Ala Leu Gly 
         195                200                205
Arg Thr Ile Leu Gly Pro Thr Glu Asn Ile Lys Ser Ile Ser Arg Lys 
     210                215                220
Asp Leu Val Asp Tyr Ile Thr Thr His Tyr Lys Gly Pro Arg Ile Val 
 225                230                235                240
Leu Ala Ala Ala Gly Gly Val Ser His Asp Glu Leu Leu Asp Leu Ala 
                 245                250                255
Lys Phe His Phe Gly Asp Ser Leu Cys Thr His Lys Gly Glu Ile Pro 
             260                265                270
Ala Leu Pro Pro Cys Lys Phe Thr Gly Ser Glu Ile Arg Val Arg Asp 
         275                280                285
Asp Lys Met Pro Leu Ala His Leu Ala Ile Ala Val Glu Ala Val Gly 
     290                295                300
Trp Ala His Pro Asp Thr Ile Cys Leu Met Val Ala Asn Thr Leu Ile 
 305                310                315                320
Gly Asn Trp Asp Arg Ser Phe Gly Gly Gly Met Asn Leu Ser Ser Lys 
                 325                330                335
Leu Ala Gln Leu Thr Cys His Gly Asn Leu Cys His Ser Phe Gln Ser 
             340                345                350
Phe Asn Thr Ser Tyr Thr Asp Thr Gly Leu Trp Gly Leu Tyr Met Val 
         355                360                365
Cys Glu Ser Ser Thr Val Ala Asp Met Leu His Val Val Gln Lys Glu 
     370                375                380
Trp Met Arg Leu Cys Thr Ser Val Thr Glu Ser Glu Val Ala Arg Ala 
 385                390                395                400
Arg Asn Leu Leu Lys Thr Asn Met Leu Leu Gln Leu Asp Gly Ser Thr 
                 405                410                415
Pro Ile Cys Glu Asp Ile Gly Arg Gln Met Leu Cys Tyr Asn Arg Arg 
             420                425                430
Ile Pro Ile Pro Glu Leu Glu Ala Arg Ile Asp Ala Val Asn Ala Glu 
         435                440                445
Thr Ile Arg Glu Val Cys Thr Lys Tyr Ile Tyr Asn Arg Ser Pro Ala 
     450                455                460
Ile Ala Ala Val Gly Pro Ile Lys Gln Leu Pro Asp Phe Lys Gln Ile 
 465                470                475                480
Arg Ser Asn Met Cys Trp Leu Arg Asp 
                 485



<210> 1695
<211> 1570
<212> DNA
<213> Rattus norvegicus
<308> D13907
<400> 1695

gcggcggct  tatcccgga  gttgttgcc  gtggccgga  ggcgcctgt  gggatttac  60
cgaaggctt  cgctccgcg  cgccgctgc  cagccattg  actttggag  ggaccgact  120
agaagtaca  aggctgctc  acaagttgt  ctgaatgtt  ctgagacac  agtcacttg  180
ttggaaaat  gactcaggg  agcttctga  aactctggg  tctcaacat  caccgttgg  240
ctgtggatc  atgctggca  tcggtatga  aatgaaaag  acaatggca  cgctcactt  300
ctggagcac  tggctttca  gggcactaa  aagaggtcc  agttagacc  tgaacttga  360
attgagaac  tgggtgccc  tctcaatgc  tatacctcc  gagagcaga  tgtctacta  420
gccaaagcc  tctccaaag  tttgccaag  gctgtagaa  ttcttgctg  cataattca  480
aacagtaca  tgagagagg  agagattga  cgtgagcgt  gagtcatcc  cagagaaat  540
caggaagtt  agaccaact  gcaagaagt  gtctttgat  atctgcacg  cacagccta  600
caaaacacc  cgctcggac  gacaattct  ggaccaacc  agaacatca  atctataag  660
cgtaaggac  tagtggact  cataaccac  cattataag  gaccaagaa  cgtgctggc  720
gctgctgga  gtgtttgcc  taacgaact  ctggagtta  cgaagtttc  ttttggtga  780
tctttgtgc  cacacaaag  agatgtacc  gctctgcct  cctgtaaat  cactggaag  840
gagattcgg  tgagggatg  caagatgcc  ctggcgcac  tcgcagtgg  tattgaagc  900
gttggttgg  cgcacccag  cacgatctg  ctcatggtc  caaacacac  gataggcaa  960
tgggaccgc  ctttcggag  aggaatgaa  ttatcgagc  agctggccc  gctcacgtg  1020
catggcaat  tctgccaca  cttccagtc  ttcaacacc  cctacacag  cacaggatt  1080
tgggggctc  atatggttt  tgaacaagc  acagttgct  acatgctgc  cgctgtaca  1140
aaggaatgg  tgcgtctgt  cacagctgt  agtgagagt  aggtcgcac  cgccaaaaa  1200
cttctcaag  caaacatgc  gctgcagct  gatgggtca  ctccgatct  tgaagacat  1260
ggtaggcag  tgctatgct  caacaggag  atccccatc  ctgagcttg  ggccaggat  1320
gatgctgtg  acgcggaga  ggttcgaga  gtgtgcacc  agtacattt  tggcaaaag  1380
ccggccatt  ctgctctcg  tcctattga  cgcttacca  attttaacc  gatttgtag  1440
aacatgcgc  ggactcgtg  ctgattttt  tgatgaatt  tcctacaca  acatattta  1500
aaaactgag  cctagaagt  ttgaaagac  gctcatctt  aagtgaaaa  ataaaaact  1560
tatttgaaac  1570



<210> 1696
<211> 489
<212> PRT
<213> Rattus norvegicus
<308> Q03346
<400> 1696

Met Ala Ala Ala Ala Val Ser Arg Thr Leu Leu Pro Val Ala Gly Arg 
  1               5                  10                  15
Arg Leu Trp Gly Phe Thr Arg Arg Leu Pro Leu Arg Ala Ala Ala Ala 
             20                  25                  30
Gln Pro Leu Tyr Phe Gly Gly Asp Arg Leu Arg Ser Thr Gln Ala Ala 
         35                  40                  45
Pro Gln Val Val Leu Asn Val Pro Glu Thr Gln Val Thr Cys Leu Glu 
     50                  55                  60
Asn Gly Leu Arg Val Ala Ser Glu Asn Ser Gly Ile Ser Thr Cys Thr 
 65                  70                  75                  80
Val Gly Leu Trp Ile Asp Ala Gly Ser Arg Tyr Glu Asn Glu Lys Asn 
                 85                  90                  95
Asn Gly Thr Ala His Phe Leu Glu His Met Ala Phe Lys Gly Thr Lys 
             100                105                110
Lys Arg Ser Gln Leu Asp Leu Glu Leu Glu Ile Glu Asn Met Gly Ala 
         115                120                125
His Leu Asn Ala Tyr Thr Ser Arg Glu Gln Thr Val Tyr Tyr Ala Lys 
     130                135                140
Ala Phe Ser Lys Asp Leu Pro Arg Ala Val Glu Ile Leu Ala Asp Ile 
 145                150                155                160
Ile Gln Asn Ser Thr Leu Gly Glu Ala Glu Ile Glu Arg Glu Arg Gly 
                 165                170                175
Val Ile Leu Arg Glu Met Gln Glu Val Glu Thr Asn Leu Gln Glu Val 
             180                185                190
Val Phe Asp Tyr Leu His Ala Thr Ala Tyr Gln Asn Thr Ala Leu Gly 
         195                200                205
Arg Thr Ile Leu Gly Pro Thr Glu Asn Ile Lys Ser Ile Ser Arg Lys 
     210                215                220
Asp Leu Val Asp Tyr Ile Thr Thr His Tyr Lys Gly Pro Arg Ile Val 
 225                230                235                240
Leu Ala Ala Ala Gly Gly Val Cys His Asn Glu Leu Leu Glu Leu Ala 
                 245                250                255
Lys Phe His Phe Gly Asp Ser Leu Cys Ala His Lys Gly Asp Val Pro 
             260                265                270
Ala Leu Pro Pro Cys Lys Phe Thr Gly Ser Glu Ile Arg Val Arg Asp 
         275                280                285
Asp Lys Met Pro Leu Ala His Leu Ala Val Ala Ile Glu Ala Val Gly 
     290                295                300
Trp Thr His Pro Asp Thr Ile Arg Leu Met Val Ala Asn Thr Leu Ile 
 305                310                315                320
Gly Asn Trp Asp Arg Ser Phe Gly Gly Gly Met Asn Leu Ser Ser Lys 
                 325                330                335
Leu Ala Gln Leu Thr Cys His Gly Asn Leu Cys His Ser Phe Gln Ser 
             340                345                350
Phe Asn Thr Ser Tyr Thr Asp Thr Gly Leu Trp Gly Leu Tyr Met Val 
         355                360                365
Cys Glu Gln Ala Thr Val Ala Asp Met Leu His Ala Val Gln Lys Glu 
     370                375                380
Trp Met Arg Leu Cys Thr Ala Val Ser Glu Ser Glu Val Ala Arg Ala 
 385                390                395                400
Lys Asn Leu Leu Lys Thr Asn Met Leu Leu Gln Leu Asp Gly Ser Thr 
                 405                410                415
Pro Ile Cys Glu Asp Ile Gly Arg Gln Met Leu Cys Tyr Asn Arg Arg 
             420                425                430
Ile Pro Ile Pro Glu Leu Glu Ala Arg Ile Asp Ala Val Asp Ala Glu 
         435                440                445
Met Val Arg Glu Val Cys Thr Lys Tyr Ile Tyr Gly Lys Ser Pro Ala 
     450                455                460
Ile Ala Ala Leu Gly Pro Ile Glu Arg Leu Pro Asp Phe Asn Gln Ile 
 465                470                475                480
Cys Ser Asn Met Arg Trp Thr Arg Asp 
                 485



<210> 1697
<211> 1771
<212> DNA
<213> Homo sapiens
<308> AF054182
<400> 1697

gttcgtagc  gaaatggcg  ctgcggcgg  tcgagtggt  ttgtcatcc  cggcgcgag  60
cggcctctg  ggtttcagc  agagtcttc  aatccgagg  gctgcggga  ggtcattat  120
ttttggaga  aacagatta  gaagtacac  ggctgctac  caagttgtt  tgaatgttc  180
tgaaacaag  gtaacatgt  tagaaagtg  actcagagt  gcttcggaa  actctgggc  240
ctcaacatg  acagttgga  tctggattg  tgctggaag  agatacgaa  atgagaaga  300
caatggaac  gcacacttt  tggagcata  ggctttcaa  ggcaccaag  agagatccc  360
gttagatct  gaacttgag  ttgaaaata  gggtgctca  ctcaatgcc  atacctcca  420
agagcagac  gtatactat  ccaaagcat  ctctaaaga  ttgccaaga  ctgtagaaa  480
tcttgctga  ataatacaa  acagcacat  gggagaagc  gagattgaa  gtgagcgtg  540
agtaatcct  agagagatg  aggaagttg  aaccaattt  caagaagtt  tttttgatt  600
tcttcatgc  acagcttat  aaaatactg  acttggacg  acaattttg  gaccaactg  660
aaatatcaa  tctataagt  gtaaggact  agtggatta  ataaccaca  attataagg  720
gccaagaat  gtgcttgct  ctgctggag  tgtttccca  gatgaattg  ttgacttag  780
aaagtttca  ttcggtgac  ctttatgca  acacaaagg  gaaatacca  ctctgcctc  840
ctgcaaatt  acaggaagt  agattcgtg  gagggatga  aagatgcct  tggcgcacc  900
tgcaatagc  gttgaagct  ttggttggg  acatccaga  acaatctgt  tcatggttg  960
aaacacgct  attggcaac  gggatcgct  ttttggggg  ggaatgaat  tatctagca  1020
gctggccca  ctcacttgt  atggcaatc  ttgccatag  tttcagtct  tcaacactt  1080
ctacacaga  acaggatta  ggggactgt  tatggtttg  gaatcatcc  ctgttgcag  1140
catgctaca  gttgttcaa  aagaatgga  gcgactctg  acaagtgtc  cagaaagtg  1200
ggttgcacg  gccagaaat  ttctgaaaa  aaacatgtt  ttgcagctt  atggttcaa  1260
tccaatttg  gaagatatt  gtaggcaaa  gttatgcta  aatagaagg  ttcccatcc  1320
tgagcttga  gcaagaatt  atgctgtga  tgctgagac  attcgagaa  tatgtacca  1380
atacattta  aataggagt  cagctattg  tgctgttgg  cccattaag  aactaccag  1440
ttttaaaca  atacgcagt  acatgtgtt  gcttcgtga  taaaatgct  ctaatcaag  1500
ttgtttgaa  acatgtatt  ataaaacag  gctagagaa  aataaaaat  aacatgtat  1560
tacatttgg  aatttgaat  aaatactgt  tcatacttt  aaaggataa  aagactacc  1620
ctctgaagg  tgttttgta  taatggtca  tctttgttc  ctgagaaat  atgttggaa  1680
cagcatact  tcaaattat  accatgagt  taattttaa  aatgaaaat  tttacagta  1740
tttcagttt  attataaaa  tgcacacac  a  1771



<210> 1698
<211> 489
<212> PRT
<213> Homo sapiens
<308> O75439
<400> 1698

Met Ala Ala Ala Ala Ala Arg Val Val Leu Ser Ser Ala Ala Arg Gly 
  1               5                  10                  15
Gly Leu Trp Gly Phe Ser Glu Ser Leu Leu Ile Arg Gly Ala Ala Gly 
             20                  25                  30
Arg Ser Leu Tyr Phe Gly Glu Asn Arg Leu Arg Ser Thr Gln Ala Ala 
         35                  40                  45
Thr Gln Val Val Leu Asn Val Pro Glu Thr Arg Val Thr Cys Leu Glu 
     50                  55                  60
Ser Gly Leu Arg Val Ala Ser Glu Asp Ser Gly Leu Ser Thr Cys Thr 
 65                  70                  75                  80
Val Gly Leu Trp Ile Asp Ala Gly Ser Arg Tyr Glu Asn Glu Lys Asn 
                 85                  90                  95
Asn Gly Thr Ala His Phe Leu Glu His Met Ala Phe Lys Gly Thr Lys 
             100                105                110
Lys Arg Ser Gln Leu Asp Leu Glu Leu Glu Ile Glu Asn Met Gly Ala 
         115                120                125
His Leu Asn Ala Tyr Thr Ser Arg Glu Gln Thr Val Tyr Tyr Ala Lys 
     130                135                140
Ala Phe Ser Lys Asp Leu Pro Arg Ala Val Glu Ile Leu Ala Asp Ile 
 145                150                155                160
Ile Gln Asn Ser Thr Leu Gly Glu Ala Glu Ile Glu Arg Glu Arg Gly 
                 165                170                175
Val Ile Leu Arg Glu Met Gln Glu Val Glu Thr Asn Leu Gln Glu Val 
             180                185                190
Val Phe Asp Tyr Leu His Ala Thr Ala Tyr Gln Asn Thr Ala Leu Gly 
         195                200                205
Arg Thr Ile Leu Gly Pro Thr Glu Asn Ile Lys Ser Ile Ser Arg Lys 
     210                215                220
Asp Leu Val Asp Tyr Ile Thr Thr His Tyr Lys Gly Pro Arg Ile Val 
 225                230                235                240
Leu Ala Ala Ala Gly Gly Val Ser His Asp Glu Leu Leu Asp Leu Ala 
                 245                250                255
Lys Phe His Phe Gly Asp Ser Leu Cys Thr His Lys Gly Glu Ile Pro 
             260                265                270
Ala Leu Pro Pro Cys Lys Phe Thr Gly Ser Glu Ile Arg Val Arg Asp 
         275                280                285
Asp Lys Met Pro Leu Ala His Leu Ala Ile Ala Val Glu Ala Val Gly 
     290                295                300
Trp Ala His Pro Asp Thr Ile Cys Leu Met Val Ala Asn Thr Leu Ile 
 305                310                315                320
Gly Asn Trp Asp Arg Ser Phe Gly Gly Gly Met Asn Leu Ser Ser Lys 
                 325                330                335
Leu Ala Gln Leu Thr Cys His Gly Asn Leu Cys His Ser Phe Gln Ser 
             340                345                350
Phe Asn Thr Ser Tyr Thr Asp Thr Gly Leu Trp Gly Leu Tyr Met Val 
         355                360                365
Cys Glu Ser Ser Thr Val Ala Asp Met Leu His Val Val Gln Lys Glu 
     370                375                380
Trp Met Arg Leu Cys Thr Ser Val Thr Glu Ser Glu Val Ala Arg Ala 
 385                390                395                400
Arg Asn Leu Leu Lys Thr Asn Met Leu Leu Gln Leu Asp Gly Ser Thr 
                 405                410                415
Pro Ile Cys Glu Asp Ile Gly Arg Gln Met Leu Cys Tyr Asn Arg Arg 
             420                425                430
Ile Pro Ile Pro Glu Leu Glu Ala Arg Ile Asp Ala Val Asn Ala Glu 
         435                440                445
Thr Ile Arg Glu Val Cys Thr Lys Tyr Ile Tyr Asn Arg Ser Pro Ala 
     450                455                460
Ile Ala Ala Val Gly Pro Ile Lys Gln Leu Pro Asp Phe Lys Gln Ile 
 465                470                475                480
Arg Ser Asn Met Cys Trp Leu Arg Asp 
                 485



<210> 1699
<211> 1673
<212> DNA
<213> Rattus norvegicus
<308> D13962
<400> 1699

ggcttaagg  aacttgctg  ggaggaaag  cattggctg  acacctcta  atctacctt  60
agacttgag  gctaggttg  gaccatggg  acagcgaag  tgaccccat  tctggtgtt  120
gctgttact  ttgccacaa  cggttcttt  cagtttggc  acaacaccg  agtcatcaa  180
gcgcctgag  caatcatta  ggactttct  aactacacg  tggaagagc  gttggaaga  240
ctaccaagg  aggggctgc  gaccacgct  tggtcgtta  gtgtggcca  cttctccgt  300
gggggcatg  ttggctctt  ttctgtcgg  ctctttgtc  accgctttg  cagacgcaa  360
tccatgctt  tagtcaacc  gattgccat  cttgggggt  gccttatgg  cttcgccaa  420
atagcggag  cggttgaaa  gctgatcct  ggccgcctg  ttattggca  cttctgtgg  480
ctgtgcacg  gctttgtgc  gatgtacat  ggagaggtg  ctcccactg  cctacgggg  540
gcatttggc  cgctaaacc  gctgggcat  gttgttggg  tccttgtgg  tcaggtctt  600
ggtttggac  ttattctgg  ctctgagga  ctgtggcct  gactactgg  cttaaccat  660
attccagct  tcctacaga  cgcagccct  ccgttttgc  ccgagagtc  aaggttctt  720
ctcattaac  gaaaggagg  agaccaagc  acggagatc  tccagcggt  gtggggcac  780
ccggatgtg  tccaggaga  ccaggagat  aaagacgag  gtatcagga  gtcacagga  840
aagcaggtc  ctgtgctgg  gctcttcaa  tctcctagc  acttccagc  ccttctcat  900
tccgttgtc  tccagttgt  tcagcagtt  tctgggatc  atgctgtgt  ctattactc  960
acgggaatc  tccaggatg  gggtgtcca  gagcccatc  atgccacga  tggagcggg  1020
gtggtcaac  ctatcttca  tgtagtctc  ctgttcctg  tggagcggg  aggaaggag  1080
accctgcac  tgataggcc  gggaggcat  gctgtttgc  ccgttttca  gacgatttc  1140
ctgttactg  aggatgaat  tgaagccat  agctttgtc  gtattgtgg  tatcttggt  1200
tacgtggcc  tctttgaga  tggccctgg  cccattccc  ggtttattg  ggctgaact  1260
ttcagccag  gcccccgac  agctgccat  gctgtggct  gctgttcta  ctggacctc  1320
aactttttg  tgggaatgt  cttcccctc  gctgcggcc  acttgggag  ctacgtttt  1380
atcatcttc  ctgccttcc  cgttttctt  ctaatcttc  cctccttca  agtcccaga  1440
accaaaggc  ggactttcg  ggatattac  cgggccttc  aggggcagg  gcactctgg  1500
aaaggctct  ctggtgtgg  gttgaacag  atgcagcct  tcaaggaga  ccctggcaa  1560
gcctgagcc  gacctcctc  ctcacctcc  tccactgtg  aaagccaac  tcccctgaa  1620
tggcgagac  tcatcagga  gaaccagga  tgcttctga  cgctcgtat  aca  1673



<210> 1700
<211> 493
<212> PRT
<213> Rattus norvegicus
<308> Q07647
<400> 1700

Met Gly Thr Ala Lys Val Thr Pro Ser Leu Val Phe Ala Val Thr Val 
  1               5                  10                  15
Ala Thr Ile Gly Ser Phe Gln Phe Gly Tyr Asn Thr Gly Val Ile Asn 
             20                  25                  30
Ala Pro Glu Thr Ile Ile Lys Asp Phe Leu Asn Tyr Thr Leu Glu Glu 
         35                  40                  45
Arg Leu Glu Asp Leu Pro Arg Glu Gly Leu Leu Thr Thr Leu Trp Ser 
     50                  55                  60
Leu Cys Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser Phe Ser 
 65                  70                  75                  80
Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met Leu Leu 
                 85                  90                  95
Val Asn Leu Ile Ala Ile Leu Gly Gly Cys Leu Met Gly Phe Ala Lys 
             100                105                110
Ile Ala Glu Ser Val Glu Met Leu Ile Leu Gly Arg Leu Ile Ile Gly 
         115                120                125
Ile Phe Cys Gly Leu Cys Thr Gly Phe Val Pro Met Tyr Ile Gly Glu 
     130                135                140
Val Ser Pro Thr Ala Leu Arg Gly Ala Phe Gly Thr Leu Asn Gln Leu 
 145                150                155                160
Gly Ile Val Val Gly Ile Leu Val Ala Gln Val Phe Gly Leu Asp Phe 
                 165                170                175
Ile Leu Gly Ser Glu Glu Leu Trp Pro Gly Leu Leu Gly Leu Thr Ile 
             180                185                190
Ile Pro Ala Ile Leu Gln Ser Ala Ala Leu Pro Phe Cys Pro Glu Ser 
         195                200                205
Pro Arg Phe Leu Leu Ile Asn Arg Lys Glu Glu Asp Gln Ala Thr Glu 
     210                215                220
Ile Leu Gln Arg Leu Trp Gly Thr Pro Asp Val Ile Gln Glu Ile Gln 
 225                230                235                240
Glu Met Lys Asp Glu Ser Ile Arg Met Ser Gln Glu Lys Gln Val Thr 
                 245                250                255
Val Leu Glu Leu Phe Lys Ser Pro Ser Tyr Phe Gln Pro Leu Leu Ile 
             260                265                270
Ser Val Val Leu Gln Leu Ser Gln Gln Phe Ser Gly Ile Asn Ala Val 
         275                280                285
Phe Tyr Tyr Ser Thr Gly Ile Phe Gln Asp Ala Gly Val Gln Glu Pro 
     290                295                300
Ile Tyr Ala Thr Ile Gly Ala Gly Val Val Asn Thr Ile Phe Thr Val 
 305                310                315                320
Val Ser Leu Phe Leu Val Glu Arg Ala Gly Arg Arg Thr Leu His Met 
                 325                330                335
Ile Gly Leu Gly Gly Met Ala Val Cys Ser Val Phe Met Thr Ile Ser 
             340                345                350
Leu Leu Leu Lys Asp Glu Tyr Glu Ala Met Ser Phe Val Cys Ile Val 
         355                360                365
Ala Ile Leu Val Tyr Val Ala Phe Phe Glu Ile Gly Pro Gly Pro Ile 
     370                375                380
Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg Pro Ala 
 385                390                395                400
Ala Met Ala Val Ala Gly Cys Ser Asn Trp Thr Ser Asn Phe Leu Val 
                 405                410                415
Gly Met Phe Phe Pro Ser Ala Ala Ala Tyr Leu Gly Ala Tyr Val Phe 
             420                425                430
Ile Ile Phe Ala Ala Phe Leu Val Phe Phe Leu Ile Phe Thr Ser Phe 
         435                440                445
Lys Val Pro Glu Thr Lys Gly Arg Thr Phe Glu Asp Ile Thr Arg Ala 
     450                455                460
Phe Glu Gly Gln Ala His Ser Gly Lys Gly Ser Ala Gly Val Glu Leu 
 465                470                475                480
Asn Ser Met Gln Pro Val Lys Glu Thr Pro Gly Asn Ala 
                 485                490



<210> 1701
<211> 3915
<212> DNA
<213> Homo sapiens
<308> M20681
<400> 1701

gtggggtgg  gtggggctg  gggcttgtc  ccctttcag  ctccaccct  tgcggagat  60
ataaatagt  atgatccca  cgagaccca  agatgcctg  aatggtgag  ctttggatc  120
ttcctgagg  cgtggagaa  actttctgc  gagaaggac  ttttgaagg  tttgttggc  180
gaaaaagct  tttctggaa  cacccctag  tctttcttg  agacttgaa  tagattaca  240
cgatgggga  acagaaggt  accccagct  tgatatttg  catcacagt  gctacaatc  300
gctctttcc  atttggcta  aacactggg  tcatcaatg  tcctgagaa  atcataaag  360
aatttatca  taaaacttt  acggacaag  gaaatgccc  accctctga  gtgctgctc  420
cgtctctct  gtccttgtc  gtggccata  tttccgtcg  gggtatgat  ggctccttt  480
ccgtcggac  cttcgtcaa  cgctttggc  ggcgcaatt  aatgctgat  gtcaacctg  540
tggctgtca  tggtggctg  tttatggga  tgtgtaaag  agctaagtc  gttgaaatg  600
tgatcctgg  tcgcttggt  attggcctc  tctgcggac  ctgcacagg  tttgtgccc  660
tgtacattg  agagatctc  cctactgcc  tgcggggtg  ctttggcac  ctcaaccag  720
tgggcatcg  tgttggaat  ctggtggcc  agatctttg  tctggaatt  atccttggg  780
ctgaagagc  atggccgct  ctactgggt  ttaccatcc  tcctgctat  ctacaaagt  840
cagcccttc  attttgccc  gaaagtccc  gatttttgc  cattaacag  aaagaagag  900
agaatgcta  gcagatcct  cagcggttg  ggggcaccc  ggatgtatc  caagacatc  960
aggagatga  agatgagag  gcaaggatg  cacaagaaa  gcaagtcac  gtgctagag  1020
tctttagag  gtccagcta  cgacagccc  tcatcattt  cattgtgct  cagctctct  1080
agcagctct  tgggatcaa  gctgtgttc  attactcaa  aggaatctt  aaggatgca  1140
gtgttcaag  gcccatcta  gccaccatc  gcgcgggtg  ggttaatac  atcttcact  1200
tagtttctc  atttctggt  gaaagggca  gaagaagga  tctgcatat  ataggcctt  1260
gagggatgg  tttttgttc  acgctcatg  ctgtttctt  gttattaaa  gataactat  1320
atgggatga  ctttgtctg  attggggct  tcttggtct  tgtagcctt  tttgaaatt  1380
gaccaggcc  cattccctg  tttattgtg  ccgaactct  cagccaggg  ccccgccca  1440
ctgcgatgg  agtggccgg  tgctccaac  ggacctcca  cttcctagt  ggattgctc  1500
tcccctccg  tgctcacta  ttaggagcc  acgttttta  tatcttcac  ggcttcctc  1560
ttaccttct  ggcttttac  ttcttcaaa  tccctgaga  ccgtggcag  acttttgag  1620
atatcacac  ggcctttga  gggcaggca  acggtgcag  tagatctgg  aaggacggc  1680
tcatggaga  gaacagcat  gagcctgct  aggagacca  caccaatgt  taagtcgtg  1740
ctccttcca  ctccctccc  gcatgggaa  gccacctct  cctcaacaa  ggagagacc  1800
catcaggat  aacccagga  gcttctgaa  gctgctact  aattccttt  tcatcccac  1860
cactccatg  gcaccccaa  gctgcggtt  gttggatct  caatggctt  ttaaatttt  1920
tttcctgga  atcctcttc  gcttaggag  gaccgagtg  acctacctt  atttcagga  1980
ggattggcc  cttggcaca  gacaacttt  ccagctttt  ctcccttgg  ttctgatat  2040
gccgcacta  gggatatag  agaggaaaa  taaggtgca  ttcccccaa  ctcagactt  2100
ccaggaagc  gatacatat  agtgtggaa  ccggagggt  tttatgtaa  agcaccttc  2160
tcacttcca  acagctcta  gtggcaaat  aacttgagt  ttatttatt  tatcctctg  2220
tttaattac  taatttttt  ttttttact  taagtttca  gatacatgt  ccgaatgtg  2280
aggtttgtt  cataggtat  tatatgcca  gatggaaat  tttattttt  taagcgtaa  2340
tttgccaaa  aataaaaac  gaaggaaat  gagattaga  ggaggtgtt  aaagagagg  2400
tatagagta  aagatttga  gctggagag  ttaaggtgc  ataagaatt  agggagaaa  2460
gttgttcat  attggaggg  aaatgatgt  gtgcctgag  tctgtacgt  acctcttaa  2520
aatttctgt  cttcagatg  aaactcttt  acttctcgt  aaagtcata  acctatata  2580
taaagctac  gatttcctt  gagcttttt  ctttaagat  atagtttac  tgtagtagt  2640
cttgaaatc  aggattatt  actaatatg  gcattgtag  taatgatgg  tgatgggtt  2700
taattttgg  tggagtcca  ggaagagaa  gtgatttct  gaaagcctg  tcccctcac  2760
ggatgaaat  actccttct  gtagtagtc  cattacttt  gaagtaatc  cgccaccta  2820
ctcgtggga  agccatcca  ataagaaac  taaaataat  ggttcttgg  agagattca  2880
tatttttcc  ctttgttct  taggagatt  taggtgttg  ttttctgtt  tattttaac  2940
cataccttt  aaggaattc  ccaaagaat  tttatagca  acttggaat  tgtaacctc  3000
gctctggga  aggattttt  tctgagcga  tattatcta  agtgtgttg  tgctttagg  3060
tcacggcac  cttgcgtat  tctgttacc  tgtcactgt  gtcctatgc  gaatgccct  3120
aggggactt  aatctttcc  ataaaccag  tttagacag  atgagtcaa  gtgcagtgt  3180
gcccacact  gagaggatg  atgtatgtg  actgtcact  tgctctggg  ggaagtacg  3240
tattgttga  ttattttct  tgtgtttgt  cctacagcc  ctttttcat  tgttgctca  3300
tctcccttt  ccttcttgg  gcttacaca  ctcagaccc  ttagccaaa  ccttgtcag  3360
gacagtatt  tggttctta  ttctcactg  tccctctgc  cctggagcc  ttgaataaa  3420
atgcacgta  ctgaggccg  atgcggtgg  tcacgcctg  aatcccagc  ctttgggag  3480
cctaggcgg  cggtcaggg  ttcgagacc  gtctggcca  catcgtgaa  ccctgtctc  3540
actaaaaat  caaaaatta  ccgggcgtg  tggcgggcg  ctgtaatcc  agctacttg  3600
gaagctgag  cgggagaat  atgtgaacc  gggacgcag  ggttgcagt  agcggagat  3660
gcatcattg  actctagcc  gggccacag  gcgagactc  gtctcaaaa  aaaaaaaat  3720
cacatagct  tcgagtgtg  tttagcttg  aaaggtgac  ttgcaactt  atgtcaact  3780
tctggctcc  caaacagta  gttggcagt  aggcagggt  ccatttctc  ctgagaaga  3840
tgtgaatat  tccatatgg  ttttctatt  ttactctgg  tctttgttt  aaaataaaa  3900
ttctgaatg  acacg  3915



<210> 1702
<211> 496
<212> PRT
<213> Homo sapiens
<308> P11169
<400> 1702

Met Gly Thr Gln Lys Val Thr Pro Ala Leu Ile Phe Ala Ile Thr Val 
  1               5                  10                  15
Ala Thr Ile Gly Ser Phe Gln Phe Gly Tyr Asn Thr Gly Val Ile Asn 
             20                  25                  30
Ala Pro Glu Lys Ile Ile Lys Glu Phe Ile Asn Lys Thr Leu Thr Asp 
         35                  40                  45
Lys Gly Asn Ala Pro Pro Ser Glu Val Leu Leu Thr Ser Leu Trp Ser 
     50                  55                  60
Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser Phe Ser 
 65                  70                  75                  80
Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met Leu Ile 
                 85                  90                  95
Val Asn Leu Leu Ala Val Thr Gly Gly Cys Phe Met Gly Leu Cys Lys 
             100                105                110
Val Ala Lys Ser Val Glu Met Leu Ile Leu Gly Arg Leu Val Ile Gly 
         115                120                125
Leu Phe Cys Gly Leu Cys Thr Gly Phe Val Pro Met Tyr Ile Gly Glu 
     130                135                140
Ile Ser Pro Thr Ala Leu Arg Gly Ala Phe Gly Thr Leu Asn Gln Leu 
 145                150                155                160
Gly Ile Val Val Gly Ile Leu Val Ala Gln Ile Phe Gly Leu Glu Phe 
                 165                170                175
Ile Leu Gly Ser Glu Glu Leu Trp Pro Leu Leu Leu Gly Phe Thr Ile 
             180                185                190
Leu Pro Ala Ile Leu Gln Ser Ala Ala Leu Pro Phe Cys Pro Glu Ser 
         195                200                205
Pro Arg Phe Leu Leu Ile Asn Arg Lys Glu Glu Glu Asn Ala Lys Gln 
     210                215                220
Ile Leu Gln Arg Leu Trp Gly Thr Gln Asp Val Ser Gln Asp Ile Gln 
 225                230                235                240
Glu Met Lys Asp Glu Ser Ala Arg Met Ser Gln Glu Lys Gln Val Thr 
                 245                250                255
Val Leu Glu Leu Phe Arg Val Ser Ser Tyr Arg Gln Pro Ile Ile Ile 
             260                265                270
Ser Ile Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn Ala Val 
         275                280                285
Phe Tyr Tyr Ser Thr Gly Ile Phe Lys Asp Ala Gly Val Gln Glu Pro 
     290                295                300
Ile Tyr Ala Thr Ile Gly Ala Gly Val Val Asn Thr Ile Phe Thr Val 
 305                310                315                320
Val Ser Leu Phe Leu Val Glu Arg Ala Gly Arg Arg Thr Leu His Met 
                 325                330                335
Ile Gly Leu Gly Gly Met Ala Phe Cys Ser Thr Leu Met Thr Val Ser 
             340                345                350
Leu Leu Leu Lys Asp Asn Tyr Asn Gly Met Ser Phe Val Cys Ile Gly 
         355                360                365
Ala Ile Leu Val Phe Val Ala Phe Phe Glu Ile Gly Pro Gly Pro Ile 
     370                375                380
Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg Pro Ala 
 385                390                395                400
Ala Met Ala Val Ala Gly Cys Ser Asn Trp Thr Ser Asn Phe Leu Val 
                 405                410                415
Gly Leu Leu Phe Pro Ser Ala Ala His Tyr Leu Gly Ala Tyr Val Phe 
             420                425                430
Ile Ile Phe Thr Gly Phe Leu Ile Thr Phe Leu Ala Phe Thr Phe Phe 
         435                440                445
Lys Val Pro Glu Thr Arg Gly Arg Thr Phe Glu Asp Ile Thr Arg Ala 
     450                455                460
Phe Glu Gly Gln Ala His Gly Ala Asp Arg Ser Gly Lys Asp Gly Val 
 465                470                475                480
Met Glu Met Asn Ser Ile Glu Pro Ala Lys Glu Thr Thr Thr Asn Val 
                 485                490                495



<210> 1703
<211> 4418
<212> DNA
<213> Rattus norvegicus
<308> D13963
<400> 1703

gaggcgact  agttgctgg  gcgcgagtc  ccaagtcac  aacttttcc  gtgctctcg  60
tgtctggcc  gattcccgg  gtgtcagca  agcacgggg  gactccttc  tccaccggt  120
ctcaagacc  cccggtaac  ttctttccc  cagcccagg  gcagatggg  aggctcccg  180
tgctgctgc  atggctagc  tggtggttg  cgcaggcag  catagcctg  ggtgccggc  240
ccgtgcgcc  ggccggtgg  ctgacgctg  gcggactat  cccagtgca  gcgcgggga  300
ccgcaggac  cgcgtgcgg  gcgctgaag  aagagcaag  cgtgcaccg  ctggaagcg  360
tgctctacg  gctggaccg  gtcaacgct  acccggagc  gctgcccgg  gtgcggctg  420
gcgcgcggc  gctcgacac  tgctcgcgg  acacctacg  tttggagca  gctctgagc  480
tcgtgcagg  gctcatccg  ggccgcgga  acggcgacg  ggccagtgt  cgctgccct  540
ggggagttc  cccgctgcg  tccgcgcct  cagagcgcg  ggtggcggt  gtgggagcc  600
cggctagct  cgtgtccat  atggtggcc  acgtcttgc  cctgtttgc  ataccccag  660
tcagctatg  ctccacagc  ccagagctc  gtgactcca  acgctatga  ttcttctcc  720
gagtggtgc  tcctgactc  taccaggcc  aggccatgg  ggacattgt  cgggcactg  780
gatggaatt  cgtgtctac  ttggcctct  agggcaact  tggcgagag  ggggttgag  840
cctttgtgc  gatttcccg  gaggctgga  gtgtctgta  tgcccagtc  ataaagatt  900
ccagggagc  aaagccggg  gagttccac  aagtgatcc  gaggctcat  gagacaccc  960
acgcccgtg  catcatcat  tttgccaat  aggatgaca  caggagggt  ttggaggca  1020
cacgccagg  caacctgac  ggccacttc  tgtgggttg  ctcagacag  tggggatcc  1080
agatctctc  catcttgaa  ctagaggaa  aggctgtgg  ggccatcac  atcttgccc  1140
aaagggctt  aatcgacgg  tttgaccaa  acttcatga  tcgttcctt  gagaacaac  1200
gcagaaaca  ctggtttgc  gagttctgg  aagagaatt  taactgcaa  ctaaccagc  1260
ccggtggcc  gtcagatga  tccacccgg  aatgcacag  tgaggaacg  atcggccag  1320
actccgcct  tgagcagga  gggaaggtg  agttcgtga  agacgctgt  tacgccatt  1380
ctcacgctc  gcatagcat  caccaagcg  tctgcccag  ccacacagg  ctgtgccca  1440
ccatggagc  tactgatgg  cggacgctg  tgcactaca  ccgagcagt  cgcttcaat  1500
gtagtgcag  aaccccagt  atgttcaat  agaatggag  tgcccccgg  cgctatgac  1560
tcttccagt  ccaggcaac  aacggaagc  ccagcagcg  cgggtacca  gccgtgggc  1620
aatgggcag  ggcccttag  ctggatatg  aagttctac  gtggtcagg  gacccccac  1680
aagtgcccc  ttctcagtg  agcctcccc  gcgggcccg  tgaacggaa  aagatggtg  1740
agggtgtcc  ctgctgttg  cactgtgag  cctgcgacg  gtaccgctt  caggtggac  1800
agttcacat  cgaggcctg  ccaggggac  tgaggccca  ccccaacca  actggttgc  1860
gtcccacac  cgtggtgcg  ctgacctgg  cctctccat  ggcagctct  ccccttctc  1920
tggctgtcc  gggcatcat  gctaccacc  ccattatgg  caccttcat  cgacacaat  1980
acactccca  agtccgcgc  tctggccgt  agcttagct  cgtgctgct  actggcatc  2040
tcctgatct  cgccatcac  ttcctcatg  tagccgagc  ttgtgcagc  atctgtgct  2100
cccgcagac  cttgcttgg  ttgggcacc  cgctcagct  ctcagccct  ctcaccaag  2160
ccaaccgca  ctaccgcat  tttgagcaa  ggaagcgct  tgtcacacc  ccacccttc  2220
tcagcccca  ttcgcaact  gtcatcacc  tcggcctca  ctccctgca  gtggtggga  2280
tgatagcat  gctgggggc  cagcctcca  acagcgtga  tgactacga  gagcagagg  2340
cggtggacc  cgagcaggc  aggggtgtg  tcaagtgtg  tatgtctga  ctgtccctc  2400
ttggttgcc  gggctacag  ctcctgctc  tggtcacgt  tacagtgta  gccatcaag  2460
cccgaggtg  gcctgagac  ttcaatgag  ccaagccca  cggcttcac  atgtacacc  2520
cctgtatta  ctggctggc  tttgttccc  tcttctttg  taccgccca  tcagctgag  2580
agatctaca  ccaaaccac  acactaact  tgtcactga  cctgagtgc  tcagtgtcc  2640
tcggcatgc  ctacgtgcc  aaaacctac  tcatcctgt  ccatccaga  cagaacgta  2700
agaagcgga  gcgcagcct  aagaagacc  ccacgatgg  agccccacc  cagaacgag  2760
acgcagagg  cgccaagta  caaggttga  tgtgggtgc  acaggttgc  ccctgccct  2820
tctctgctt  tcctggctt  aaagtggaa  ctgtgaaag  tccacagag  ccatcggag  2880
ccaggaatg  gtaaagacc  tgcccatgg  cttttccga  ggaaaaagc  aaaccccga  2940
cacgctgga  ttgtgcttt  ctgggcacg  caaccacat  attctgccc  tccgaccca  3000
tgtaagaaa  actgcttcc  ggaatcttc  tgaagagag  cgaaactga  accttctgg  3060
caggcattc  aaaccatag  gaagccagg  cttggccag  ttgggataa  atttatctt  3120
atccaacac  acaacctag  ggctggcca  ggtgtctgt  agaatgtgt  aaccccaac  3180
agaaatcca  gattagagc  gggtggggg  tgcaatcac  acaatagga  acttagagg  3240
ctgaatttg  ggaaatatt  ccctgagca  agcctgtat  agggttctg  gaactgagt  3300
tgagcctgc  gcagagaga  gagcagtac  gggaactgg  gcaggcttc  gtgaggtcg  3360
ttcccttgt  gtcttttcc  cagggtcat  caaaagatt  gacagtttt  ctctgctgt  3420
tatgtttcc  tagattact  caacttgaa  aaatgccaa  acattacag  gggtaagag  3480
tggtaaggt  tagctagac  ttggtcaga  tgtccatga  ttgtcttgt  tctgcactt  3540
agagttgtt  ttgttgttg  tgttgttgt  gttgttgtt  ttattatta  tattattat  3600
attattatt  tcattatct  gagtgaggg  ctcactatg  aactctggc  gtcctagaa  3660
ttactatgt  gaccaggtt  gccatgaac  cacagagat  tgctggctt  tgcctccca  3720
gtgctggga  caaaggtgt  tgtcactat  cccagctta  aattttaat  actaggatg  3780
gcacaaaag  tcccttgca  agagtcttg  agcgcccac  tgaaaggtg  tggaggcat  3840
tggagggac  catgggaac  ccatgcacg  gctttagtt  tgactatta  ttttacaga  3900
ctggttttt  gttagggaa  ttttctttc  tcgtttttt  ttgttgttt  gttgtttgg  3960
ttttttttt  atttgtttg  tttaatgta  agagctaaa  gctttaatt  attgtgaat  4020
ctccagtat  taaggtaca  aactaagtt  tgaaagtat  ctagctaca  ttcaatgga  4080
agatgctcc  aggtgtaat  agctttgat  ttgagatgt  atactttac  tagtatctt  4140
aaggcaaca  gcttctctc  agaacatct  tgctgttcc  ctcttcctc  cttgctgtg  4200
tcccggttt  ccacggtgc  aagcacagc  cagcattta  tgctgagtg  gctctgatg  4260
tccgttctg  ggcttctgt  ctaggtcaa  cctcaaagt  tgaaatgtg  tctcccggg  4320
gagccttgt  cacgtgacc  tctgcatgg  gtttttctc  tctgggatc  cttctagag  4380
cggtgagcc  aggtctgaa  aaaggtttt  ttgcactt  4418



<210> 1704
<211> 871
<212> PRT
<213> Rattus norvegicus
<308> P35349
<400> 1704

Met Gly Arg Leu Pro Val Leu Leu Leu Trp Leu Ala Trp Trp Leu Ser 
  1               5                  10                  15
Gln Ala Gly Ile Ala Cys Gly Ala Gly Ser Val Arg Leu Ala Gly Gly 
             20                  25                  30
Leu Thr Leu Gly Gly Leu Phe Pro Val His Ala Arg Gly Ala Ala Gly 
         35                  40                  45
Arg Ala Cys Gly Ala Leu Lys Lys Glu Gln Gly Val His Arg Leu Glu 
     50                  55                  60
Ala Met Leu Tyr Ala Leu Asp Arg Val Asn Ala Asp Pro Glu Leu Leu 
 65                  70                  75                  80
Pro Gly Val Arg Leu Gly Ala Arg Leu Leu Asp Thr Cys Ser Arg Asp 
                 85                  90                  95
Thr Tyr Ala Leu Glu Gln Ala Leu Ser Phe Val Gln Ala Leu Ile Arg 
             100                105                110
Gly Arg Gly Asp Gly Asp Glu Ala Ser Val Arg Cys Pro Gly Gly Val 
         115                120                125
Pro Pro Leu Arg Ser Ala Pro Pro Glu Arg Val Val Ala Val Val Gly 
     130                135                140
Ala Ser Ala Ser Ser Val Ser Ile Met Val Ala Asn Val Leu Arg Leu 
 145                150                155                160
Phe Ala Ile Pro Gln Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser 
                 165                170                175
Asp Ser Thr Arg Tyr Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser 
             180                185                190
Tyr Gln Ala Gln Ala Met Val Asp Ile Val Arg Ala Leu Gly Trp Asn 
         195                200                205
Tyr Val Ser Thr Leu Ala Ser Glu Gly Asn Tyr Gly Glu Ser Gly Val 
     210                215                220
Glu Ala Phe Val Gln Ile Ser Arg Glu Ala Gly Gly Val Cys Ile Ala 
 225                230                235                240
Gln Ser Ile Lys Ile Pro Arg Glu Pro Lys Pro Gly Glu Phe His Lys 
                 245                250                255
Val Ile Arg Arg Leu Met Glu Thr Pro Asn Ala Arg Gly Ile Ile Ile 
             260                265                270
Phe Ala Asn Glu Asp Asp Ile Arg Arg Val Leu Glu Ala Thr Arg Gln 
         275                280                285
Ala Asn Leu Thr Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly 
     290                295                300
Ser Lys Ile Ser Pro Ile Leu Asn Leu Glu Glu Glu Ala Val Gly Ala 
 305                310                315                320
Ile Thr Ile Leu Pro Lys Arg Ala Ser Ile Asp Gly Phe Asp Gln Tyr 
                 325                330                335
Phe Met Thr Arg Ser Leu Glu Asn Asn Arg Arg Asn Ile Trp Phe Ala 
             340                345                350
Glu Phe Trp Glu Glu Asn Phe Asn Cys Lys Leu Thr Ser Ser Gly Gly 
         355                360                365
Gln Ser Asp Asp Ser Thr Arg Lys Cys Thr Gly Glu Glu Arg Ile Gly 
     370                375                380
Gln Asp Ser Ala Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp 
 385                390                395                400
Ala Val Tyr Ala Ile Ala His Ala Leu His Ser Met His Gln Ala Leu 
                 405                410                415
Cys Pro Gly His Thr Gly Leu Cys Pro Ala Met Glu Pro Thr Asp Gly 
             420                425                430
Arg Thr Leu Leu His Tyr Ile Arg Ala Val Arg Phe Asn Gly Ser Ala 
         435                440                445
Gly Thr Pro Val Met Phe Asn Glu Asn Gly Asp Ala Pro Gly Arg Tyr 
     450                455                460
Asp Ile Phe Gln Tyr Gln Ala Thr Asn Gly Ser Ala Ser Ser Gly Gly 
 465                470                475                480
Tyr Gln Ala Val Gly Gln Trp Ala Glu Ala Leu Arg Leu Asp Met Glu 
                 485                490                495
Val Leu Arg Trp Ser Gly Asp Pro His Glu Val Pro Pro Ser Gln Cys 
             500                505                510
Ser Leu Pro Cys Gly Pro Gly Glu Arg Lys Lys Met Val Lys Gly Val 
         515                520                525
Pro Cys Cys Trp His Cys Glu Ala Cys Asp Gly Tyr Arg Phe Gln Val 
     530                535                540
Asp Glu Phe Thr Cys Glu Ala Cys Pro Gly Asp Met Arg Pro Thr Pro 
 545                550                555                560
Asn His Thr Gly Cys Arg Pro Thr Pro Val Val Arg Leu Thr Trp Ser 
                 565                570                575
Ser Pro Trp Ala Ala Leu Pro Leu Leu Leu Ala Val Leu Gly Ile Met 
             580                585                590
Ala Thr Thr Thr Ile Met Ala Thr Phe Met Arg His Asn Asp Thr Pro 
         595                600                605
Ile Val Arg Ala Ser Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly 
     610                615                620
Ile Phe Leu Ile Tyr Ala Ile Thr Phe Leu Met Val Ala Glu Pro Cys 
 625                630                635                640
Ala Ala Ile Cys Ala Ala Arg Arg Leu Leu Leu Gly Leu Gly Thr Thr 
                 645                650                655
Leu Ser Tyr Ser Ala Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile 
             660                665                670
Phe Glu Gln Gly Lys Arg Ser Val Thr Pro Pro Pro Phe Ile Ser Pro 
         675                680                685
Thr Ser Gln Leu Val Ile Thr Phe Gly Leu Thr Ser Leu Gln Val Val 
     690                695                700
Gly Val Ile Ala Trp Leu Gly Ala Gln Pro Pro His Ser Val Ile Asp 
 705                710                715                720
Tyr Glu Glu Gln Arg Thr Val Asp Pro Glu Gln Ala Arg Gly Val Leu 
                 725                730                735
Lys Cys Asp Met Ser Asp Leu Ser Leu Ile Gly Cys Leu Gly Tyr Ser 
             740                745                750
Leu Leu Leu Met Val Thr Cys Thr Val Tyr Ala Ile Lys Ala Arg Gly 
         755                760                765
Val Pro Glu Thr Phe Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr 
     770                775                780
Thr Thr Cys Ile Ile Trp Leu Ala Phe Val Pro Ile Phe Phe Gly Thr 
 785                790                795                800
Ala Gln Ser Ala Glu Lys Ile Tyr Ile Gln Thr Thr Thr Leu Thr Val 
                 805                810                815
Ser Leu Ser Leu Ser Ala Ser Val Ser Leu Gly Met Leu Tyr Val Pro 
             820                825                830
Lys Thr Tyr Val Ile Leu Phe His Pro Glu Gln Asn Val Gln Lys Arg 
         835                840                845
Lys Arg Ser Leu Lys Lys Thr Ser Thr Met Ala Ala Pro Pro Gln Asn 
     850                855                860
Glu Asn Ala Glu Asp Ala Lys 
 865                870



<210> 1705
<211> 6122
<212> DNA
<213> Homo sapiens
<308> NM_000843
<400> 1705

cggaggccc  ggcaggccg  ctgagctaa  tccccagag  caaagtgga  ggcgcgccc  60
gagcgcctt  tccccagga  cccggtgtc  ctccccgcg  cccgagccc  cgctctcct  120
cccccgccc  cagagcgct  cccgcccct  tgtctcccc  cagcccgct  gacgagccg  180
tggcgcggc  ccggagagc  cgggagccg  tgctcgtgg  gctgctgcc  ctggcgtgg  240
tggcgcagg  gggcctggc  cgcgcggcg  gctctgtgc  cctggcggg  ggcctgacg  300
tgggcggcc  gttcccggt  cacgcgcgg  gcgcggcgg  ccgggcgtg  gggccgctg  360
agaaggagc  gggcgtgca  cggctggag  ccatgctgt  cgcgctgga  cgcgtcaac  420
ccgaccccg  gctgctgcc  ggcgtgcgc  tgggcgcgc  gctgctgga  acctgctcg  480
gggacacct  cgcgctgga  caggcgctg  gcttcgtgc  ggcgctgat  cgcggccgc  540
gcgacggcg  cgaggtggg  gtgcgctgc  cgggaggcg  ccctccgct  cgccccgcg  600
cccccgagc  cgtcgtggc  gtcgtgggc  cctcggcca  ctccgtctc  atcatggtc  660
ccaacgtgc  gcgcctgtt  gcgataccc  agatcagct  tgcctccac  gccccggag  720
tcagcgact  cacacgcta  gacttcttc  cccgggtgg  gccacccga  tcctaccag  780
cgcaggcca  ggtggacat  gtgagggca  tgggatgga  ctatgtgtc  acgctggcc  840
ccgagggca  ctatggcga  agtggggtt  aggccttcg  tcagatctc  cgagaggct  900
ggggggtct  tattgccca  tctatcaag  ttcccaggg  accaaagcc  ggagagttc  960
gcaaggtga  caggagact  atggagacg  ccaacgccc  gggcatcat  atctttgcc  1020
atgaggatg  catcaggcg  gtcctggag  cagctcgcc  ggccaacct  accggccac  1080
tcctgtggg  cggctcaga  agctgggga  ccaagacct  acccatctt  agcctggag  1140
acgtggccg  tggggccat  accatcctg  ccaaaaggg  ctccatcga  ggatttgac  1200
agtacttca  gactcgatc  ctggagaac  accgcagga  catctggtt  gccgagttc  1260
gggaagaga  ttttaactg  aaactgacc  gctcaggta  ccagtcaga  gattccacc  1320
gcaaatgca  aggcgagga  cgcatcggc  gggactcca  ctacgagca  gagggcaag  1380
tgcagtttg  gattgatgc  gtgtatgcc  ttgcccacg  cctccacag  atgcaccag  1440
cgctctgcc  tgggcacac  ggcctgtgc  cggcgatgg  acccaccga  gggcggatg  1500
ttctgcagt  cattcgagc  gtccgcttc  acggcagcg  aggaacccc  gtgatgttc  1560
acgagaacg  ggatgcgcc  gggcggtac  acatcttcc  gtaccaggc  accaatggc  1620
gtgccagca  tggcgggta  caggcagtg  gccagtggg  agagaccct  agactggat  1680
tggaggccc  gcagtggtc  ggcgacccc  acgaggtgc  ctcgtctct  tgcagcctg  1740
cctgcgggc  gggggagcg  aagaagatg  tgaagggcg  cccctgctg  tggcactgc  1800
aggcctgtg  cgggtaccg  ttccaggtg  acgagttca  atgcgaggc  tgtcctggg  1860
acatgaggc  cacgcccaa  cacacgggc  gccgcccca  acctgtggt  cgcctgagc  1920
ggtcctccc  ctgggcagc  ccgccgctc  tcctggccg  gctgggcat  gtggccact  1980
ccacggtgg  ggccacctt  gtgcggtac  acaacacgc  catcgtccg  gcctcgggc  2040
gagagctca  ctacgtcct  ctcaccggc  tcttcctca  ctacgccat  accttcctc  2100
tggtggctg  gcctggggc  gcggtctgt  ccgcccgca  gctcttcct  ggcctgggc  2160
cgaccctca  ctactctgc  ctgctcacc  agaccaacc  tatctaccg  atctttgag  2220
agggcaagc  ctcggtcac  ccccctccc  tcatcagcc  cacctcaca  ctggtcatc  2280
ccttcagcc  cacctccct  caggtggtg  ggatgatag  atggctggg  gcccggccc  2340
cacacagcg  gattgacta  gaggaacag  ggacagtgg  ccccgagca  gccagaggg  2400
tgctcaagt  cgacatgtc  gatctgtct  tcatcggct  cctgggcta  agcctcctg  2460
tcatggtca  gtgcacagt  tacgccatc  aggcccgtg  cgtgcccga  accttcaac  2520
aggccaagc  catcggctt  accatgtac  ccacctgca  catctggct  gcattcgtg  2580
ccatcttct  tggcactgc  cagtcagct  aaaagatct  catccagac  accacgcta  2640
ccgtgtcct  gagcctgag  gcctcggtg  ccctcggca  gctctacgt  cccaaaacc  2700
acgtcatcc  cttccatcc  gagcagaat  tgcagaagc  aaagcggag  ctcaaggcc  2760
cctccacgg  ggcagcccc  cccaagggc  aggatgcag  ggcccacaa  tagcagggc  2820
ggtgggaac  ggactgctt  ctgcctctc  tttcttcct  ttgcctcga  gtggaagct  2880
tatagagcc  gggtccacg  tgaacagtc  gtggcaggg  gtttgccaa  accatgctc  2940
gcgtcggtg  ggctggcct  gagaaggaa  tggacccag  tctaccccg  ttccagcat  3000
tgagcttca  gcttcctca  cacagacca  actcgcttc  catggtggg  aacagccac  3060
gagaaggtt  tagctctag  aagggacta  acttattct  tcatccgaa  tccaaagag  3120
atgatgaag  cctgggctt  gcctggttt  cgggagatt  cctcccctc  gtcaacccc  3180
ataacctgg  gattgggca  tgtggaaga  cgtgtagac  ccagaatga  acatggggt  3240
ggagtggag  aggagctgt  tcagcaaga  gagacctgg  gctgtgcat  tggatggag  3300
cactcaggc  tgggtagga  tcctctggc  cggagggag  gaccctggg  gagacccct  3360
tgagcatgg  aagggcctg  agtgggcgc  ggagtgagc  gaggaactg  ggtgcgccc  3420
catgagatt  ccaatgcca  gggctttcc  ccatccccc  gggattggg  aaggtcaga  3480
ttagagtac  gctgttttc  tcccctctg  gtactccct  aaatcaccc  aaccttggc  3540
aggcatggt  gctcacacc  gtaatccca  cactttggg  ggccgaggc  ggtggatca  3600
ctgaggtcc  gagttcgag  ccagcctgg  caatgtggt  aaaccctgt  tctactaaa  3660
atacaaaaa  tagccaggt  tgatggtgg  tgcctgtaa  cccagttac  tgggaggct  3720
aggcaggag  atcgcttga  cctgggagg  ggaggttgc  gtgagctgt  attgtgcca  3780
tgtactcca  cctgggtga  agagcgaga  tctgtctca  aaaaacaaa  caaaaaaac  3840
ccaaaaaaa  ccccaaacc  gaagaaatt  agatacacg  gtgtaatgt  agtgatgtg  3900
gaacaagga  caggggtgc  tttgtgttg  gttcgggtt  gggatgggt  taggagctc  3960
aggttggga  cagtgacag  gagtcatgg  cgtggtgag  gtgaatccc  agtggatgg  4020
tcaggacgg  tatggaaac  cttcattcc  cataggtac  gggaagtcc  tttgcaagc  4080
gagcgccag  cctggggag  aagaggctt  ggctgcaga  gcacgcaca  ttgtttttc  4140
ctgatagtt  ttacaaaaa  cttggttta  gttatggaa  tttatgtcc  tgggagtag  4200
atttacatt  gttaaattg  ccactgttt  agatcagta  acattctct  gtctgtgat  4260
tctggagct  gttttgagg  tgaaccaca  tttatccaa  atacaaact  tcccatgca  4320
cttctctgg  gcgcagttg  ttttgaccg  gggactagg  gcttctgca  gttttaagt  4380
attaactta  aagcttctc  tctgagaaa  atttctgtt  cgctactga  tctccttct  4440
cacatttgt  gtgttccta  ggcttctct  tagtgcaca  taggacgtt  catttgttg  4500
tgaatgctt  ccagaatta  ttattccat  gggtttctc  cctgtgcag  tctctcatg  4560
gtaatgggg  gtgttttct  gccaaaggc  gttccaccc  cgtgattgt  tagggctct  4620
ctcctgtat  aactctgag  tcagtgagc  ctgatctcc  agggaaagt  ttcctgcat  4680
tgctgtttt  tcatgtctc  cccagtgtg  attctctgg  ttctagctg  aaacttttc  4740
acagtttta  attcatgtg  ttttctcca  tgtgaactc  gtgattcag  atcagaagc  4800
gttcttagt  gaggcattt  tacactgat  gcactgagg  tatctcccc  gtgtgaagt  4860
tctggcata  agtcctggc  tcccgcaga  gactttcac  ctctgccat  ttcatgcct  4920
tgggcctct  tggcaggaa  tctgatgca  cgcgaggcc  atgtactcc  gtggctttc  4980
cacattcgg  ctacttgca  ggtatctcc  cagcatgca  cattctggg  acaggggga  5040
atcctctgt  actgaagat  ttgtcatat  tagtacctt  acaaggttt  tctccttcc  5100
gaattttct  atgtacaca  ataactgac  tccacaaga  ggcttttcc  cactcggtg  5160
gtgcataca  tttctgcct  tgatcattt  tttatgtta  tattttatt  tttcgagat  5220
gggtcttgc  caatttctt  ggctggagt  cagtggcac  atcatagct  actgaagtt  5280
cgacctggg  tcaagcaat  ctcccgctt  agcctcctg  gtagctggt  cgcacgacc  5340
tacccagct  atgttttat  ttttgtaga  acgaggtct  actatgttg  ccaggctgg  5400
ctcgaactt  tgagctcga  cgatcctcc  gcctccacc  cccaaagtg  tcggattac  5460
aacgtgagc  atcgcacct  gcctctttg  tcatttctg  ggtgttcag  gggggttga  5520
agctcccta  agattttcc  gtttttttg  atgcatggg  ttgaattct  tgaggtcca  5580
tttatttgg  cccctgaat  aagttttgt  ggttttctt  tatgtgtgg  attatatag  5640
cattcttcc  gtgtggttt  tcttatgtc  agtgagagc  gacctgcac  gaagtttgt  5700
ccatttgtt  cccttgaat  atctgtatg  attatatgt  ccagtgaaa  tggagttct  5760
ggttggagg  ttattccat  tttacacaa  taaaattgc  gtgttcctc  ctgggatga  5820
agctctaaa  cagagtaag  ttacgttct  atgtaagct  taaccacct  tttataagg  5880
ctcacctgt  gtccactgt  ttgagactt  tacagaaga  cttctgtat  gtaaccatt  5940
tcttaggct  tctcacttg  gtgaatctt  tgacacatt  attatagct  tgtcccatt  6000
cttatcctt  ttgctcttt  gaaatttcc  tttaattta  tacattcat  gcttactgt  6060
aagagtcca  gtaactgac  ttaattcaa  ttacttcct  ttcaataaa  ttaactttt  6120
cc  6122



<210> 1706
<211> 877
<212> PRT
<213> Homo sapiens
<308> NP_000834
<400> 1706

Met Ala Arg Pro Arg Arg Ala Arg Glu Pro Leu Leu Val Ala Leu Leu 
  1               5                  10                  15
Pro Leu Ala Trp Leu Ala Gln Ala Gly Leu Ala Arg Ala Ala Gly Ser 
             20                  25                  30
Val Arg Leu Ala Gly Gly Leu Thr Leu Gly Gly Leu Phe Pro Val His 
         35                  40                  45
Ala Arg Gly Ala Ala Gly Arg Ala Cys Gly Pro Leu Lys Lys Glu Gln 
     50                  55                  60
Gly Val His Arg Leu Glu Ala Met Leu Tyr Ala Leu Asp Arg Val Asn 
 65                  70                  75                  80
Ala Asp Pro Glu Leu Leu Pro Gly Val Arg Leu Gly Ala Arg Leu Leu 
                 85                  90                  95
Asp Thr Cys Ser Arg Asp Thr Tyr Ala Leu Glu Gln Ala Leu Ser Phe 
             100                105                110
Val Gln Ala Leu Ile Arg Gly Arg Gly Asp Gly Asp Glu Val Gly Val 
         115                120                125
Arg Cys Pro Gly Gly Val Pro Pro Leu Arg Pro Ala Pro Pro Glu Arg 
     130                135                140
Val Val Ala Val Val Gly Ala Ser Ala Ser Ser Val Ser Ile Met Val 
 145                150                155                160
Ala Asn Val Leu Arg Leu Phe Ala Ile Pro Gln Ile Ser Tyr Ala Ser 
                 165                170                175
Thr Ala Pro Glu Leu Ser Asp Ser Thr Arg Tyr Asp Phe Phe Ser Arg 
             180                185                190
Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala Met Val Asp Ile Val 
         195                200                205
Arg Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu Ala Ser Glu Gly Asn 
     210                215                220
Tyr Gly Glu Ser Gly Val Glu Ala Phe Val Gln Ile Ser Arg Glu Ala 
 225                230                235                240
Gly Gly Val Cys Ile Ala Gln Ser Ile Lys Ile Pro Arg Glu Pro Lys 
                 245                250                255
Pro Gly Glu Phe Ser Lys Val Ile Arg Arg Leu Met Glu Thr Pro Asn 
             260                265                270
Ala Arg Gly Ile Ile Ile Phe Ala Asn Glu Asp Asp Ile Arg Arg Val 
         275                280                285
Leu Glu Ala Ala Arg Gln Ala Asn Leu Thr Gly His Phe Leu Trp Val 
     290                295                300
Gly Ser Asp Ser Trp Gly Ala Lys Thr Ser Pro Ile Leu Ser Leu Glu 
 305                310                315                320
Asp Val Ala Val Gly Ala Ile Thr Ile Leu Pro Lys Arg Ala Ser Ile 
                 325                330                335
Asp Gly Phe Asp Gln Tyr Phe Met Thr Arg Ser Leu Glu Asn Asn Arg 
             340                345                350
Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Glu Asn Phe Asn Cys Lys 
         355                360                365
Leu Thr Ser Ser Gly Thr Gln Ser Asp Asp Ser Thr Arg Lys Cys Thr 
     370                375                380
Gly Glu Glu Arg Ile Gly Arg Asp Ser Thr Tyr Glu Gln Glu Gly Lys 
 385                390                395                400
Val Gln Phe Val Ile Asp Ala Val Tyr Ala Ile Ala His Ala Leu His 
                 405                410                415
Ser Met His Gln Ala Leu Cys Pro Gly His Thr Gly Leu Cys Pro Ala 
             420                425                430
Met Glu Pro Thr Asp Gly Arg Met Leu Leu Gln Tyr Ile Arg Ala Val 
         435                440                445
Arg Phe Asn Gly Ser Ala Gly Thr Pro Val Met Phe Asn Glu Asn Gly 
     450                455                460
Asp Ala Pro Gly Arg Tyr Asp Ile Phe Gln Tyr Gln Ala Thr Asn Gly 
 465                470                475                480
Ser Ala Ser Ser Gly Gly Tyr Gln Ala Val Gly Gln Trp Ala Glu Thr 
                 485                490                495
Leu Arg Leu Asp Val Glu Ala Leu Gln Trp Ser Gly Asp Pro His Glu 
             500                505                510
Val Pro Ser Ser Leu Cys Ser Leu Pro Cys Gly Pro Gly Glu Arg Lys 
         515                520                525
Lys Met Val Lys Gly Val Pro Cys Cys Trp His Cys Glu Ala Cys Asp 
     530                535                540
Gly Tyr Arg Phe Gln Val Asp Glu Phe Thr Cys Glu Ala Cys Pro Gly 
 545                550                555                560
Asp Met Arg Pro Thr Pro Asn His Thr Gly Cys Arg Pro Thr Pro Val 
                 565                570                575
Val Arg Leu Ser Trp Ser Ser Pro Trp Ala Ala Pro Pro Leu Leu Leu 
             580                585                590
Ala Val Leu Gly Ile Val Ala Thr Thr Thr Val Val Ala Thr Phe Val 
         595                600                605
Arg Tyr Asn Asn Thr Pro Ile Val Arg Ala Ser Gly Arg Glu Leu Ser 
     610                615                620
Tyr Val Leu Leu Thr Gly Ile Phe Leu Ile Tyr Ala Ile Thr Phe Leu 
 625                630                635                640
Met Val Ala Glu Pro Gly Ala Ala Val Cys Ala Ala Arg Arg Leu Phe 
                 645                650                655
Leu Gly Leu Gly Thr Thr Leu Ser Tyr Ser Ala Leu Leu Thr Lys Thr 
             660                665                670
Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val Thr Pro 
         675                680                685
Pro Pro Phe Ile Ser Pro Thr Ser Gln Leu Val Ile Thr Phe Ser Leu 
     690                695                700
Thr Ser Leu Gln Val Val Gly Met Ile Ala Trp Leu Gly Ala Arg Pro 
 705                710                715                720
Pro His Ser Val Ile Asp Tyr Glu Glu Gln Arg Thr Val Asp Pro Glu 
                 725                730                735
Gln Ala Arg Gly Val Leu Lys Cys Asp Met Ser Asp Leu Ser Leu Ile 
             740                745                750
Gly Cys Leu Gly Tyr Ser Leu Leu Leu Met Val Thr Cys Thr Val Tyr 
         755                760                765
Ala Ile Lys Ala Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro 
     770                775                780
Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Val 
 785                790                795                800
Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu Lys Ile Tyr Ile Gln 
                 805                810                815
Thr Thr Thr Leu Thr Val Ser Leu Ser Leu Ser Ala Ser Val Ser Leu 
             820                825                830
Gly Met Leu Tyr Val Pro Lys Thr Tyr Val Ile Leu Phe His Pro Glu 
         835                840                845
Gln Asn Val Gln Lys Arg Lys Arg Ser Leu Lys Ala Thr Ser Thr Val 
     850                855                860
Ala Ala Pro Pro Lys Gly Glu Asp Ala Glu Ala His Lys 
 865                870                875



<210> 1707
<211> 2424
<212> DNA
<213> Rattus norvegicus
<308> D13978
<400> 1707

ggctgactg  cagcctttt  ttttttttt  ttaatattt  attggagat  gggtctata  60
cccaggcta  cttgagcta  tttatgcag  ttgggatga  ctagaactt  tgatcttcc  120
acttcaatc  cccgaaagc  gaggttact  gcatacaca  catgcttcg  tagtagtct  180
tgttggcct  gaacctgcg  caagccttt  gcctcagct  ccagagtac  ggaatgatc  240
gcatacaaa  ccatacctg  tttagcacg  gacctacct  ctgcccact  ttttgagac  300
gggtctcac  atctagtac  ggttggccc  taactcact  tgcaaacta  gctgtctta  360
aactggcag  tccgtctgt  tctgcctcc  aagggttga  attgttttg  aacaggttc  420
tctgcaacc  agacctgga  ctcccagca  tcttcctgc  tcggcctcc  aaatgctgc  480
gggatgaca  gcctctcat  tcttcaccc  agtacagac  ttatgtgct  gcccctcag  540
acagctagt  ctgattccc  gaaaaatca  ctcttcctg  tactagtag  tcaaccaga  600
atagtcccg  ccataggcg  gattgatga  tcacaccca  ctctcccaa  tggttctac  660
cttccagga  gcggggaca  ggcaggggc  gcagacgcc  tccggacca  aaaaagcca  720
gagagacca  aaggtgcct  gtccctgag  gtctggtcc  ctaactcca  ggactgtgg  780
acagaggaa  aaacaagaa  gaactcgag  cctcgctga  tggcgcgct  gctgagtgc  840
gccacatcc  gcaagctga  caggtatcc  aactctgtt  ctgcccggt  gaccacccg  900
ggtggtgag  gtggtcttg  cttccagat  cgtaggaca  aagctccag  aggaggacc  960
gcccaacat  gcatcggag  gcgggaagc  atggggtgg  cgatttgca  gctcggtcg  1020
ccccaccat  gacaagttc  actcatcta  cgcctatga  cggcatctg  ggaatgtgg  1080
cctgcaggg  agcaaggcc  acagcaggg  cctggagaa  gcagggctt  tcaccaaag  1140
tgagatgca  cagatactg  aaggcctgg  caaggtggc  gaagagtgg  cccaaggca  1200
cttcaaatt  taccctaat  atgaagaca  ccacacggc  aacgagcgg  gcctgaagg  1260
actcattgg  gaagctgca  ggaagttac  cacaggcag  agtcgcaat  accaggtgg  1320
cacggacct  aggctgtgg  tgaggcaaa  ctgctcaaa  ctctccacc  tcctcaagg  1380
gctcattga  gccatggta  accgggcag  ggcggagtg  gaagtcctc  tccctgggt  1440
cacacactt  cagagagct  agcccatcc  ctggagcca  tggatcctg  gtcacgccg  1500
tgcgctgac  cgagattta  agagactga  ggaggtgca  aagcggatc  atgtcctgc  1560
actgggcag  ggggccatt  caggcaacc  tctgggtgt  gaccgggag  tcctctgtg  1620
agaactgaa  tttggagcc  ttacgctca  cagtatgga  gccaccagc  agagagact  1680
cgtggctga  ttcctgttt  gggcttctc  gtgcatgac  catctcagc  ggatggcag  1740
agacctgat  ctctacggt  ccaaggaat  caactttgt  cagctctcc  atgcctaca  1800
caccggaag  agcttgatg  cccagaaga  aaacccaga  agcttggag  tgatccgga  1860
caaggcggg  cgagtgttt  gacggtgcg  aggactcct  atgaccctc  agggacttc  1920
aagcaccta  aacaaggac  tacaggaag  caaggaggc  gtgtttgaa  tgtctgaca  1980
catgacagc  gtcctccaa  tagccactg  agtcatctc  acactgcag  ttcatcgtg  2040
gaacatggc  caggcactc  gccctgaca  gctggctac  gaccttgcc  actacctgg  2100
ccgcaaagg  atgccattc  gccaggccc  cgaggcctc  gggaaagct  tggtcgtgg  2160
agagatgaa  ggggtggct  tcaaccagc  gtcacttca  gagctgcag  ccgtcagtc  2220
cctgttctc  agtgacgtg  atctcgtgt  ggactacag  cacagcgtg  agcagtaca  2280
agccttggg  ggcacagca  agtccagtg  tgagtggca  atcagccag  tgcgggccc  2340
gctgcagat  tagcagccc  agattccac  cagtcaaac  tgcgcccca  taaagtgga  2400
ccctggaga  gccgccata  accc  2424



<210> 1708
<211> 461
<212> PRT
<213> Rattus norvegicus
<308> BAA03088
<400> 1708

Met Ala Ser Glu Ser Gly Lys Leu Trp Gly Gly Arg Phe Ala Gly Ser 
  1               5                  10                  15
Val Asp Pro Thr Met Asp Lys Phe Asn Ser Ser Ile Ala Tyr Asp Arg 
             20                  25                  30
His Leu Trp Asn Val Asp Leu Gln Gly Ser Lys Ala Tyr Ser Arg Gly 
         35                  40                  45
Leu Glu Lys Ala Gly Leu Leu Thr Lys Ala Glu Met Gln Gln Ile Leu 
     50                  55                  60
Gln Gly Leu Asp Lys Val Ala Glu Glu Trp Ala Gln Gly Ile Phe Lys 
 65                  70                  75                  80
Leu Tyr Pro Asn Asp Glu Asp Ile His Thr Ala Asn Glu Arg Arg Leu 
                 85                  90                  95
Lys Glu Leu Ile Gly Glu Ala Ala Gly Lys Leu His Thr Gly Arg Ser 
             100                105                110
Arg Asn Asp Gln Val Val Thr Asp Leu Arg Leu Trp Met Arg Gln Thr 
         115                120                125
Tyr Ser Lys Leu Ser Thr Phe Leu Lys Val Leu Ile Glu Ala Met Val 
     130                135                140
Asp Arg Ala Glu Ala Glu Cys Glu Val Leu Phe Pro Gly Tyr Thr His 
 145                150                155                160
Leu Gln Arg Ala Gln Pro Ile Arg Trp Ser His Trp Ile Leu Ser His 
                 165                170                175
Ala Val Ala Leu Thr Arg Asp Leu Glu Arg Leu Lys Glu Val Gln Lys 
             180                185                190
Arg Ile Asn Val Leu Pro Leu Gly Ser Gly Ala Ile Ala Gly Asn Pro 
         195                200                205
Leu Gly Val Asp Arg Glu Phe Leu Cys Ala Glu Leu Asn Phe Gly Ala 
     210                215                220
Ile Thr Leu Asn Ser Met Asp Ala Thr Ser Glu Arg Asp Phe Val Ala 
 225                230                235                240
Glu Phe Leu Phe Trp Ala Ser Leu Cys Met Thr His Leu Ser Arg Met 
                 245                250                255
Ala Glu Asp Leu Ile Leu Tyr Gly Thr Lys Glu Phe Asn Phe Val Gln 
             260                265                270
Leu Ser Asp Ala Tyr Ser Thr Gly Ser Ser Leu Met Pro Gln Lys Lys 
         275                280                285
Asn Pro Asp Ser Leu Glu Leu Ile Arg Ser Lys Ala Arg Arg Val Phe 
     290                295                300
Gly Arg Cys Ala Gly Leu Leu Met Thr Leu Lys Gly Leu Pro Ser Thr 
 305                310                315                320
Tyr Asn Lys Asp Leu Gln Glu Asp Lys Glu Ala Val Phe Glu Val Ser 
                 325                330                335
Asp Thr Met Thr Ala Val Leu Gln Val Ala Thr Gly Val Ile Ser Thr 
             340                345                350
Leu Gln Ile His Arg Glu Asn Met Ala Gln Ala Leu Ser Pro Asp Met 
         355                360                365
Leu Ala Thr Asp Leu Ala Tyr Tyr Leu Val Arg Lys Gly Met Pro Phe 
     370                375                380
Arg Gln Ala His Glu Ala Ser Gly Lys Ala Val Val Val Ala Glu Met 
 385                390                395                400
Lys Gly Val Ala Leu Asn Gln Leu Ser Leu Gln Glu Leu Gln Thr Val 
                 405                410                415
Ser Pro Leu Phe Ser Ser Asp Val Asn Leu Val Trp Asp Tyr Ser His 
             420                425                430
Ser Val Glu Gln Tyr Thr Ala Leu Gly Gly Thr Ala Gln Ser Ser Val 
         435                440                445
Glu Trp Gln Ile Ser Gln Val Arg Ala Leu Leu Gln Met 
     450                455                460



<210> 1709
<211> 1563
<212> DNA
<213> Homo sapiens
<308> BC008195
<400> 1709

gcgcgacac  atccgtgcg  ccaggcgga  acccggagg  ccgaagctt  cggacgacg  60
ggaaccgcc  aacatggcc  cggagagtg  gaagctttg  ggtggccgg  ttgtgggtg  120
agtggaccc  atcatggag  agttcaacg  gtccattgc  tacgaccgg  acctttggg  180
ggtggatgt  caaggcagc  aagcctaca  caggggcct  gagaaggca  ggctcctca  240
caaggccga  atggaccag  tactccatg  cctagacaa  gtggctgag  agtgggccc  300
gggcacctt  aaactgaac  ccaatgatg  ggacatcca  acagccaat  agcgccgcc  360
gaaggagct  attggtgca  cggcaggga  gctgcacac  ggacggagc  ggaatgacc  420
ggtggtcac  gacctcagg  tgtggatgc  gcagacctg  tccacgctc  cgggcctcc  480
ctgggagct  attaggacc  tggtggatc  ggcagaggc  gaacgtgat  ttctcttcc  540
ggggtacac  catttgcag  gggcccagc  catccgctg  agccactgg  ttctgagcc  600
cgccgtggc  ctgacccga  actctgagc  gctgctgga  gtgcggaag  ggatcaatg  660
cctgcccct  gggagtggg  ccattgcag  caatcccct  ggtgtggac  gagagctgc  720
ccgagcaga  ctcaacttt  gggccatca  tctcaacag  atggatgcc  ctagtgagc  780
ggactttgt  gccgagttc  tgttctggg  ttcgctgtg  atgacccat  tcagcagga  840
ggccgagga  ctcatcctc  actgcacca  ggaattcag  ttcgtgcag  tctcagatg  900
ctacagcac  ggaagcagc  tgatgcccc  gaagaaaaa  cccgacagt  tggagctga  960
ccggagcaa  gctgggcgt  tgtttgggc  gtgtgccgg  ctcctgatg  ccctcaagg  1020
acttcccag  acctacaac  aagacttac  ggaggacaa  gaagctgtg  ttgaagtgt  1080
agacactat  agtgccgtg  tccaggtgg  cactggcgt  atctctacg  tgcagattc  1140
ccaagagaa  atgggacag  ctctcagcc  cgacatgct  gccactgac  ttgcctatt  1200
cctggtccg  aaagggatg  cattccgcc  ggcccacga  gcctccggg  aagctgtgt  1260
catggccga  accaagggg  tcgccctca  ccagctgtc  ctgcaggag  tgcagacca  1320
cagccccct  ttctcgggc  acgtgatct  cgtgtggga  tacgggcac  gtgtggagc  1380
gtatggtgc  ctgggcggc  ctgcgcgct  cagcgtcga  tggcagatc  gccaggtgc  1440
ggcgctact  caggcacag  aggcctagg  cctcccaca  ctgccccct  ataaagtgg  1500
cgcgagagg  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1560
aaa  1563



<210> 1710
<211> 464
<212> PRT
<213> Homo sapiens
<308> P04424
<400> 1710

Met Ala Ser Glu Ser Gly Lys Leu Trp Gly Gly Arg Phe Val Gly Ala 
  1               5                  10                  15
Val Asp Pro Ile Met Glu Lys Phe Asn Ala Ser Ile Ala Tyr Asp Arg 
             20                  25                  30
His Leu Trp Glu Val Asp Val Gln Gly Ser Lys Ala Tyr Ser Arg Gly 
         35                  40                  45
Leu Glu Lys Ala Gly Leu Leu Thr Lys Ala Glu Met Asp Gln Ile Leu 
     50                  55                  60
His Gly Leu Asp Lys Val Ala Glu Glu Trp Ala Gln Gly Thr Phe Lys 
 65                  70                  75                  80
Leu Asn Ser Asn Asp Glu Asp Ile His Thr Ala Asn Glu Arg Arg Leu 
                 85                  90                  95
Lys Glu Leu Ile Gly Ala Thr Ala Gly Lys Leu His Thr Gly Arg Ser 
             100                105                110
Arg Asn Asp Gln Val Val Thr Asp Leu Arg Leu Trp Met Arg Gln Thr 
         115                120                125
Cys Ser Thr Leu Ser Gly Leu Leu Trp Glu Leu Ile Arg Thr Met Val 
     130                135                140
Asp Arg Ala Glu Ala Glu Arg Asp Val Leu Phe Pro Gly Tyr Thr His 
 145                150                155                160
Leu Gln Arg Ala Gln Pro Ile Arg Trp Ser His Trp Ile Leu Ser His 
                 165                170                175
Ala Val Ala Leu Thr Arg Asp Ser Glu Arg Leu Leu Glu Val Arg Lys 
             180                185                190
Arg Ile Asn Val Leu Pro Leu Gly Ser Gly Ala Ile Ala Gly Asn Pro 
         195                200                205
Leu Gly Val Asp Arg Glu Leu Leu Arg Ala Glu Leu Asn Phe Gly Ala 
     210                215                220
Ile Thr Leu Asn Ser Met Asp Ala Thr Ser Glu Arg Asp Phe Val Ala 
 225                230                235                240
Glu Phe Leu Phe Trp Arg Ser Leu Cys Met Thr His Leu Ser Arg Met 
                 245                250                255
Ala Glu Asp Leu Ile Leu Tyr Cys Thr Lys Glu Phe Ser Phe Val Gln 
             260                265                270
Leu Ser Asp Ala Tyr Ser Thr Gly Ser Ser Leu Met Pro Gln Lys Lys 
         275                280                285
Asn Pro Asp Ser Leu Glu Leu Ile Arg Ser Lys Ala Gly Arg Val Phe 
     290                295                300
Gly Arg Cys Ala Gly Leu Leu Met Thr Leu Lys Gly Leu Pro Ser Thr 
 305                310                315                320
Tyr Asn Lys Asp Leu Gln Glu Asp Lys Glu Ala Val Phe Glu Val Ser 
                 325                330                335
Asp Thr Met Ser Ala Val Leu Gln Val Ala Thr Gly Val Ile Ser Thr 
             340                345                350
Leu Gln Ile His Gln Glu Asn Met Gly Gln Ala Leu Ser Pro Asp Met 
         355                360                365
Leu Ala Thr Asp Leu Ala Tyr Tyr Leu Val Arg Lys Gly Met Pro Phe 
     370                375                380
Arg Gln Ala His Glu Ala Ser Gly Lys Ala Val Phe Met Ala Glu Thr 
 385                390                395                400
Lys Gly Val Ala Leu Asn Gln Leu Ser Leu Gln Glu Leu Gln Thr Ile 
                 405                410                415
Ser Pro Leu Phe Ser Gly Asp Val Ile Cys Val Trp Asp Tyr Gly His 
             420                425                430
Ser Val Glu Gln Tyr Gly Ala Leu Gly Gly Thr Ala Arg Ser Ser Val 
         435                440                445
Asp Trp Gln Ile Arg Gln Val Arg Ala Leu Leu Gln Ala Gln Gln Ala 
     450                455                460



<210> 1711
<211> 978
<212> DNA
<213> Rattus norvegicus
<308> D13985
<400> 1711

aatggaagc  ggggcggcc  gggagaccc  ggtcttgca  ccaggcata  tggggatga  60
ggatcgtgc  ctgctttct  ggttcctgt  gagcaatgc  ttcgcccgc  atgagcttc  120
tcaaaagct  cccgccccc  gggtccgca  atggactcc  gctgcagca  ccagacacc  180
aagctgtgc  gaacgggaa  gggctcggc  ccggcacgc  ttacattgc  gagagccgc  240
tgtcttggc  agatggttc  ggattagga  tctcactgg  gtaccccac  attagttta  300
atgcggtat  cagggaccc  aatgcttat  ctcaagaac  tctgtatgt  atggtgaat  360
ccagatttg  agaagaatc  aaagaacct  tctctgatg  agatgagga  gacaatgat  420
atgttgaac  catttctga  tttagattt  tgcccagtg  taagtcagc  ttggaggcg  480
tgttcacag  aatgtgtga  tgccaggcc  tgcatccag  ccctgagga  gaagactcg  540
atgactatg  tggagaaga  tatgatgtg  aagcacatg  gcaaggaca  ggggacatc  600
ctacatttt  cacctatga  gaaggacta  cccatttaa  agcagaagg  caagccacg  660
tggagagat  agaaggaat  ctttctcag  ctgtgagca  ccagtataa  atggcaggc  720
tccgaacag  agattcagt  agaacttac  aagatggca  ggaggtaga  accacacca  780
ctgttgccg  acagttcga  gatgcagac  ttgaccact  aggatgact  gtgtgactt  840
cagtgaatt  tgctcataa  tataggcaa  aacttgatg  ctcttcact  cagaatgga  900
ctggtgaaa  gcttatttc  tctccaaaa  tcatttctc  agacaaact  taatgagac  960
gcaagctgt  accagcag  978



<210> 1712
<211> 236
<212> PRT
<213> Rattus norvegicus
<308> Q04753
<400> 1712

Met Ser Phe Leu Lys Ser Phe Pro Pro Pro Gly Ser Ala Asp Gly Leu 
  1               5                  10                  15
Arg Leu Gln Gln Pro Asp Thr Glu Ala Val Leu Asn Gly Lys Gly Leu 
             20                  25                  30
Gly Thr Gly Thr Leu Tyr Ile Ala Glu Ser Arg Leu Ser Trp Leu Asp 
         35                  40                  45
Gly Ser Gly Leu Gly Phe Ser Leu Glu Tyr Pro Thr Ile Ser Leu His 
     50                  55                  60
Ala Val Ser Arg Asp Pro Asn Ala Tyr Pro Gln Glu His Leu Tyr Val 
 65                  70                  75                  80
Met Val Asn Ala Arg Phe Gly Glu Glu Ser Lys Glu Pro Phe Ser Asp 
                 85                  90                  95
Glu Asp Glu Asp Asp Asn Asp Asp Val Glu Pro Ile Ser Glu Phe Arg 
             100                105                110
Phe Val Pro Ser Asp Lys Ser Ala Leu Glu Ala Met Phe Thr Ala Met 
         115                120                125
Cys Glu Cys Gln Ala Leu His Pro Asp Pro Glu Asp Glu Asp Ser Asp 
     130                135                140
Asp Tyr Asp Gly Glu Glu Tyr Asp Val Glu Ala His Glu Gln Gly Gln 
 145                150                155                160
Gly Asp Ile Pro Thr Phe Tyr Thr Tyr Glu Glu Gly Leu Ser His Leu 
                 165                170                175
Thr Ala Glu Gly Gln Ala Thr Leu Glu Arg Leu Glu Gly Met Leu Ser 
             180                185                190
Gln Ser Val Ser Ser Gln Tyr Asn Met Ala Gly Val Arg Thr Glu Asp 
         195                200                205
Ser Val Arg Thr Tyr Glu Asp Gly Met Glu Val Glu Thr Thr Pro Thr 
     210                215                220
Val Ala Gly Gln Phe Glu Asp Ala Asp Val Asp His 
 225                230                235



<210> 1713
<211> 421
<212> DNA
<213> Homo sapiens
<308> AA832121
<400> 1713

ttttttttc  aattgttga  taaaataat  taaaagtgt  ctgtttgtt  agaacaagg  60
caaggggac  tccctacat  ttataccta  gaagaagga  tatcccatt  aacagcgga  120
gggcaagcc  cgttggaga  attagaagg  atgctttct  agtctgtga  cagccaata  180
aatatggca  gcgtccgaa  agaagactc  gtaagaaat  atgaaggtg  gtgtttttt  240
tcttcagac  gggaaatcg  agccaagtt  tctcttaga  gccagaaga  tgcagagtc  300
ttgctccag  ctctcatac  gttttggct  tgaaggagt  acatgtggc  gtcctgtgc  360
ttctaaccc  aagccgatt  tgtgccaca  ctggattta  agcacatct  tcaatattt  420
c  421



<210> 1714
<211> 237
<212> PRT
<213> Homo sapiens
<308> NP_001284
<400> 1714

Met Ser Phe Leu Lys Ser Phe Pro Pro Pro Gly Pro Ala Glu Gly Leu 
  1               5                  10                  15
Leu Arg Gln Gln Pro Asp Thr Glu Ala Val Leu Asn Gly Lys Gly Leu 
             20                  25                  30
Gly Thr Gly Thr Leu Tyr Ile Ala Glu Ser Arg Leu Ser Trp Leu Asp 
         35                  40                  45
Gly Ser Gly Leu Gly Phe Ser Leu Glu Tyr Pro Thr Ile Ser Leu His 
     50                  55                  60
Ala Leu Ser Arg Asp Arg Ser Asp Cys Leu Gly Glu His Leu Tyr Val 
 65                  70                  75                  80
Met Val Asn Ala Lys Phe Glu Glu Glu Ser Lys Glu Pro Val Ala Asp 
                 85                  90                  95
Glu Glu Glu Glu Asp Ser Asp Asp Asp Val Glu Pro Ile Thr Glu Phe 
             100                105                110
Arg Phe Val Pro Ser Asp Lys Ser Ala Leu Glu Ala Met Phe Thr Ala 
         115                120                125
Met Cys Glu Cys Gln Ala Leu His Pro Asp Pro Glu Asp Glu Asp Ser 
     130                135                140
Asp Asp Tyr Asp Gly Glu Glu Tyr Asp Val Glu Ala His Glu Gln Gly 
 145                150                155                160
Gln Gly Asp Ile Pro Thr Phe Tyr Thr Tyr Glu Glu Gly Leu Ser His 
                 165                170                175
Leu Thr Ala Glu Gly Gln Ala Thr Leu Glu Arg Leu Glu Gly Met Leu 
             180                185                190
Ser Gln Ser Val Ser Ser Gln Tyr Asn Met Ala Gly Val Arg Thr Glu 
         195                200                205
Asp Ser Ile Arg Asp Tyr Glu Asp Gly Met Glu Val Asp Thr Thr Pro 
     210                215                220
Thr Val Ala Gly Gln Phe Glu Asp Ala Asp Val Asp His 
 225                230                235



<210> 1715
<211> 978
<212> DNA
<213> Rattus norvegicus
<308> D13985
<400> 1715

aatggaagc  ggggcggcc  gggagaccc  ggtcttgca  ccaggcata  tggggatga  60
ggatcgtgc  ctgctttct  ggttcctgt  gagcaatgc  ttcgcccgc  atgagcttc  120
tcaaaagct  cccgccccc  gggtccgca  atggactcc  gctgcagca  ccagacacc  180
aagctgtgc  gaacgggaa  gggctcggc  ccggcacgc  ttacattgc  gagagccgc  240
tgtcttggc  agatggttc  ggattagga  tctcactgg  gtaccccac  attagttta  300
atgcggtat  cagggaccc  aatgcttat  ctcaagaac  tctgtatgt  atggtgaat  360
ccagatttg  agaagaatc  aaagaacct  tctctgatg  agatgagga  gacaatgat  420
atgttgaac  catttctga  tttagattt  tgcccagtg  taagtcagc  ttggaggcg  480
tgttcacag  aatgtgtga  tgccaggcc  tgcatccag  ccctgagga  gaagactcg  540
atgactatg  tggagaaga  tatgatgtg  aagcacatg  gcaaggaca  ggggacatc  600
ctacatttt  cacctatga  gaaggacta  cccatttaa  agcagaagg  caagccacg  660
tggagagat  agaaggaat  ctttctcag  ctgtgagca  ccagtataa  atggcaggc  720
tccgaacag  agattcagt  agaacttac  aagatggca  ggaggtaga  accacacca  780
ctgttgccg  acagttcga  gatgcagac  ttgaccact  aggatgact  gtgtgactt  840
cagtgaatt  tgctcataa  tataggcaa  aacttgatg  ctcttcact  cagaatgga  900
ctggtgaaa  gcttatttc  tctccaaaa  tcatttctc  agacaaact  taatgagac  960
gcaagctgt  accagcag  978



<210> 1716
<211> 236
<212> PRT
<213> Rattus norvegicus
<308> Q04753
<400> 1716

Met Ser Phe Leu Lys Ser Phe Pro Pro Pro Gly Ser Ala Asp Gly Leu 
  1               5                  10                  15
Arg Leu Gln Gln Pro Asp Thr Glu Ala Val Leu Asn Gly Lys Gly Leu 
             20                  25                  30
Gly Thr Gly Thr Leu Tyr Ile Ala Glu Ser Arg Leu Ser Trp Leu Asp 
         35                  40                  45
Gly Ser Gly Leu Gly Phe Ser Leu Glu Tyr Pro Thr Ile Ser Leu His 
     50                  55                  60
Ala Val Ser Arg Asp Pro Asn Ala Tyr Pro Gln Glu His Leu Tyr Val 
 65                  70                  75                  80
Met Val Asn Ala Arg Phe Gly Glu Glu Ser Lys Glu Pro Phe Ser Asp 
                 85                  90                  95
Glu Asp Glu Asp Asp Asn Asp Asp Val Glu Pro Ile Ser Glu Phe Arg 
             100                105                110
Phe Val Pro Ser Asp Lys Ser Ala Leu Glu Ala Met Phe Thr Ala Met 
         115                120                125
Cys Glu Cys Gln Ala Leu His Pro Asp Pro Glu Asp Glu Asp Ser Asp 
     130                135                140
Asp Tyr Asp Gly Glu Glu Tyr Asp Val Glu Ala His Glu Gln Gly Gln 
 145                150                155                160
Gly Asp Ile Pro Thr Phe Tyr Thr Tyr Glu Glu Gly Leu Ser His Leu 
                 165                170                175
Thr Ala Glu Gly Gln Ala Thr Leu Glu Arg Leu Glu Gly Met Leu Ser 
             180                185                190
Gln Ser Val Ser Ser Gln Tyr Asn Met Ala Gly Val Arg Thr Glu Asp 
         195                200                205
Ser Val Arg Thr Tyr Glu Asp Gly Met Glu Val Glu Thr Thr Pro Thr 
     210                215                220
Val Ala Gly Gln Phe Glu Asp Ala Asp Val Asp His 
 225                230                235



<210> 1717
<211> 421
<212> DNA
<213> Homo sapiens
<308> AA832121
<400> 1717

ttttttttc  aattgttga  taaaataat  taaaagtgt  ctgtttgtt  agaacaagg  60
caaggggac  tccctacat  ttataccta  gaagaagga  tatcccatt  aacagcgga  120
gggcaagcc  cgttggaga  attagaagg  atgctttct  agtctgtga  cagccaata  180
aatatggca  gcgtccgaa  agaagactc  gtaagaaat  atgaaggtg  gtgtttttt  240
tcttcagac  gggaaatcg  agccaagtt  tctcttaga  gccagaaga  tgcagagtc  300
ttgctccag  ctctcatac  gttttggct  tgaaggagt  acatgtggc  gtcctgtgc  360
ttctaaccc  aagccgatt  tgtgccaca  ctggattta  agcacatct  tcaatattt  420
c  421



<210> 1718
<211> 237
<212> PRT
<213> Homo sapiens
<308> NP_001284
<400> 1718

Met Ser Phe Leu Lys Ser Phe Pro Pro Pro Gly Pro Ala Glu Gly Leu 
  1               5                  10                  15
Leu Arg Gln Gln Pro Asp Thr Glu Ala Val Leu Asn Gly Lys Gly Leu 
             20                  25                  30
Gly Thr Gly Thr Leu Tyr Ile Ala Glu Ser Arg Leu Ser Trp Leu Asp 
         35                  40                  45
Gly Ser Gly Leu Gly Phe Ser Leu Glu Tyr Pro Thr Ile Ser Leu His 
     50                  55                  60
Ala Leu Ser Arg Asp Arg Ser Asp Cys Leu Gly Glu His Leu Tyr Val 
 65                  70                  75                  80
Met Val Asn Ala Lys Phe Glu Glu Glu Ser Lys Glu Pro Val Ala Asp 
                 85                  90                  95
Glu Glu Glu Glu Asp Ser Asp Asp Asp Val Glu Pro Ile Thr Glu Phe 
             100                105                110
Arg Phe Val Pro Ser Asp Lys Ser Ala Leu Glu Ala Met Phe Thr Ala 
         115                120                125
Met Cys Glu Cys Gln Ala Leu His Pro Asp Pro Glu Asp Glu Asp Ser 
     130                135                140
Asp Asp Tyr Asp Gly Glu Glu Tyr Asp Val Glu Ala His Glu Gln Gly 
 145                150                155                160
Gln Gly Asp Ile Pro Thr Phe Tyr Thr Tyr Glu Glu Gly Leu Ser His 
                 165                170                175
Leu Thr Ala Glu Gly Gln Ala Thr Leu Glu Arg Leu Glu Gly Met Leu 
             180                185                190
Ser Gln Ser Val Ser Ser Gln Tyr Asn Met Ala Gly Val Arg Thr Glu 
         195                200                205
Asp Ser Ile Arg Asp Tyr Glu Asp Gly Met Glu Val Asp Thr Thr Pro 
     210                215                220
Thr Val Ala Gly Gln Phe Glu Asp Ala Asp Val Asp His 
 225                230                235



<210> 1719
<211> 3751
<212> DNA
<213> Rattus norvegicus
<308> D14014
<400> 1719

agaaagaga  ctacagact  cgcgcgctc  ggaagaccg  gtcgtagag  tcgagacaa  60
tcccgccag  agcaagaca  gggagaccc  accaggatg  caaccctcc  caggccgcc  120
gctccatgg  acaccagct  ctgtgctgc  aagtggaga  catccgccg  gcgtaccct  180
acaccaatc  cctcaaccg  ccgggtctg  gagccatgc  taagactga  gagacctgc  240
cgccctccg  ttcttactt  aagtgcgtg  agagggaga  tgtgccatc  atgcggaaa  300
tcgtggcca  ctggatgct  gaggtctgc  aggagcaga  gtgcgaaga  gaggtcttc  360
cgctggcca  gaactacct  gaccgtttc  tgtctctgg  gcccctgaa  aagagccgc  420
tgcagcttc  gggggccac  tgcatgttc  tggcctcta  gatgaagga  accattccc  480
tgactgccg  gaagttgtg  atctacact  acaactcta  ccgccccga  gagttgctg  540
aaatggaac  gcttctggt  aacaagctc  aatggaacc  ggccgccat  actccccac  600
atttcatcg  acacttcct  tccaaaatg  cagaggcgg  tgagaacaa  cagatcatc  660
gcaaacatg  acagacctt  gtggccctc  gtgccacag  tgtgaagtt  atttccaac  720
caccctcca  ggtggctgc  gggagtgtg  tggccgcga  gcagggcct  aacctgggc  780
gccccaaca  cttcctctc  tgctaccgc  caacgcact  tctttccag  gtcatcaag  840
gtgacccgg  ctgcctccg  gcctgccag  aacagattg  agcccttct  gagtcaagc  900
tgcgccagg  ccagcagaa  atcgatccc  aggccaccg  ggaggaagg  gaagtggag  960
aagaagctg  tctggcttg  acacccacc  acgtccgag  tgtggacat  tgagggccc  1020
ccgggcagg  gggagtcac  aagtagtgg  atccgcgaa  agaaaggag  cagcccggg  1080
gctcctgac  aggtccccc  tggggatgt  ttgttacca  aaggggaag  tttgttctc  1140
ttgttggtt  tttttcctt  atctttctc  tttctatct  atttaagca  aagagaaaa  1200
aatacctga  agctgtctt  aagagagag  gagagatag  attcgcatc  ccctgagta  1260
agggagacg  gggggtgcc  acaaaaata  aattctgta  cccagtaat  aactagttt  1320
ctattaatg  gcttgtctg  tctaagaat  ggattaaca  acaggaagt  ttgagaagg  1380
tttttgatt  ttttatgtg  ttaagaaaa  aaagcttaa  aaacattgc  ttaaaaaaa  1440
aaggaaaaa  aatacagca  accattgtt  aagtagaag  gttttaggt  gagaaatgt  1500
ctctgcttt  gtgaaaagg  acagatttg  gaaggtcct  aacctcact  ccctgcttg  1560
tcagtgcct  cagacctgt  acctgatga  acctgtgct  tatcccagg  gtggggcag  1620
cctcttaac  ttactgatg  tcgattcga  ctctagcgg  ctcgtgggt  tggcaacct  1680
cagggctca  gttatgggc  ctctgcccc  cacaacctg  aggttcaca  agcgccagc  1740
agcacgcag  ggtagggat  aaatagtga  ataatatat  ctatttttg  ggaaccttc  1800
tgttttggg  gttcctgtt  agagagatg  tggtttttg  ctggtggcc  tgcagccca  1860
tcaacatca  gttgaaccc  cagcttttc  tttgtgtgt  gtttgtttt  ttatgtttt  1920
ccttctcca  gttcccaaa  ccattccat  tcaaagcac  tttggtcag  tagctggag  1980
cagtgttgc  gggtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtcgg  2040
gggggaggg  gtctagtgg  atggttggg  atgtccaca  actcaattc  gatggctgc  2100
cagcaggtg  gtagggctg  tagcatgag  tgcttggga  gttgtgttg  gtcgagaag  2160
gaaagctct  ttctcgtac  accgggatc  tcctgcaaa  tcggaggga  cttttggtg  2220
cagctggcg  ttggaagta  ggaccgtga  ggcattacc  ggacaaggg  attcaggac  2280
actcttaag  ctttcacac  ggaggcttt  aaacactaa  atctctaat  tatacgtaa  2340
gctacagaa  agtatttat  gggaaggtt  cccatgacc  gtgtgactc  aagcaatgt  2400
atcttccct  gattcaaac  cacaccttc  tccctgctg  cgaaggttt  aggccattg  2460
ctgagagac  ggtctttta  tggccaagt  gggtgtcct  caaaaaaac  aaaccacaa  2520
gacggagat  tgggtctcc  tgactttcc  aacccaatt  cccccattg  agagccatc  2580
aaacctgag  aaaattagg  gaccccaaa  gagtcttga  tctggcaca  tcttgccgc  2640
gctcccaag  tagcaacag  aggtaattt  cacacctct  gctctgtgc  tttctgttc  2700
ggatgtgtt  gtgggaggt  gagagcggg  ggctggaga  gggatgtga  agaagaagt  2760
tggagggta  ggaccacac  ggacagacc  cggctcctt  cacagcgct  ctaccaatg  2820
ctcccagga  ccccggcgt  cggaaccag  ttcacgttg  tttgtatct  tcatgttgt  2880
ttcgctgct  ttggagggt  agttttatt  tgttgttgt  ggtttgttt  ttttttttt  2940
caatgtcat  aactgccat  ttcaagttt  aatttcctc  tagaagagt  tatttacag  3000
tgccctctc  gggactttt  ctatttatt  tgattcaat  ttggattaa  gtgattacc  3060
ctgtattcc  aacaaaagg  gttttccac  cacacacac  cacacacac  cacacacac  3120
cacacacac  ggttcctgt  cacaatacc  catgtatca  ctaacaata  ataggcctg  3180
caggcgggt  gggcggtct  cctccaggg  ccctgggac  ctgctgggg  tcatcctgt  3240
atgctgggc  ttcatttga  ctgggacat  gcatcacag  agtcaggcc  actgtgttc  3300
gttagttat  aatattgtt  cttgtagcg  cctgttgtg  atgccacca  gctgctgga  3360
ccggagaga  ttgttctga  tctctggtg  atcatataa  ctgttaggt  ctagtgttc  3420
gtcttgttt  gtgttactc  cagcattgt  ctaatgtaa  gccagccgc  atgctgtag  3480
ccccaggtt  cctagcaag  tgccaaacc  aaagggtca  caccagctt  gctgaggcg  3540
cccaaccag  caggaccct  gagggctgc  gtgtccatg  tgatggggt  aagttttgg  3600
caaagggcc  aaggctggt  gatccacac  gtctgccct  tgacatgaa  ggctttgag  3660
ggctctggc  ggtggtcag  ttggctttg  gtattctgg  tgacacacc  tggcgcttc  3720
cagcacaga  atgtgacca  catggtcca  g  3751



<210> 1720
<211> 295
<212> PRT
<213> Rattus norvegicus
<308> BAA03115
<400> 1720

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
  1               5                  10                  15
Tyr Pro Asp Thr Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
             20                  25                  30
Lys Thr Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
         35                  40                  45
Gln Arg Glu Ile Val Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Leu Lys Lys 
                 85                  90                  95
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
             100                105                110
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
     130                135                140
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
 145                150                155                160
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Asp Glu Asn Lys Gln 
                 165                170                175
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
             180                185                190
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
         195                200                205
Val Ala Ala Met Gln Gly Leu Asn Leu Gly Ser Pro Asn Asn Phe Leu 
     210                215                220
Ser Cys Tyr Arg Thr Thr His Phe Leu Ser Arg Val Ile Lys Cys Asp 
 225                230                235                240
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                 245                250                255
Ser Ser Leu Arg Gln Ala Gln Gln Asn Ile Asp Pro Lys Ala Thr Glu 
             260                265                270
Glu Glu Gly Glu Val Glu Glu Glu Ala Gly Leu Ala Cys Thr Pro Thr 
         275                280                285
Asp Val Arg Asp Val Asp Ile 
     290                295



<210> 1721
<211> 4244
<212> DNA
<213> Homo sapiens
<308> X59798
<400> 1721

ggcgcagta  cagcgagca  cagagtccg  acgctccgg  gaggggcag  agagcgcga  60
ggagcgcgg  gcagcagaa  cgagagccg  gcgcggacc  agccaggac  cacagccct  120
cccagctgc  caggaagag  cccagccat  gaacaccag  tcctgtgct  cgaagtgga  180
accatccgc  gcgcgtacc  cgatgccaa  ctcctcaac  accgggtgc  gcgggccat  240
ctgaaggcg  aggagacct  cgcgccctc  gtgtcctac  tcaaatgtg  gcagaagga  300
gtcctgccg  ccatgcgga  gatcgtcgc  acctggatg  tggaggtct  cgaggaaca  360
aagtgcgag  aggaggtct  cccgctggc  atgaactac  tggaccgct  cctgtcgct  420
gagcccgtg  aaaagagcc  cctgcagct  ctgggggcc  cttgcatgt  cgtggcctc  480
aagatgaag  agaccatcc  cctgacggc  gagaagctg  gcatctaca  cgacaactc  540
atccggccc  aggagctgc  gcaaatgga  ctgctcctg  tgaacaagc  caagtggaa  600
ctggccgca  tgaccccgc  cgatttcat  gaacacttc  tctccaaaa  gccagaggc  660
gaggagaac  aacagatca  ccgcaaaca  gcgcagacc  tcgttgccc  ctgtgccac  720
gatgtgaag  tcatttcca  tccgccctc  atggtggca  cggggagcg  ggtggccgc  780
gtgcaaggc  tgaacctga  gagccccaa  aacttcctg  cctactacc  cctcacacg  840
ttcctctcc  gagtgatca  gtgtgaccc  gactgcctc  gggcctgcc  ggagcagat  900
gaagccctg  tggagtcaa  cctgcgcca  gcccagcag  acatggacc  caaggccgc  960
gaggaggag  aagaggagg  ggaggaggt  gacctggct  gcacaccca  cgacgtgcg  1020
gacgtggac  tctgagggc  ccaggcagg  gggcgccac  gccacccgc  gcgagggcg  1080
agccggccc  aggtgctcc  ctgacagtc  ctcctctcc  gagcatttt  ataccagaa  1140
ggaaagctt  attctcctt  ttgttggtt  ttttttcct  tgctctttc  cccttccat  1200
tctgactta  gcaaaagaa  aagattacc  aaaaactgt  tttaaaaga  agagagaga  1260
aaaaaaaat  gtatttgca  aaccctgag  ggtggggga  gagggttgt  ctacagatg  1320
tagaggatt  tatacccca  taatcaact  gtttttata  taatgtact  gtttctctg  1380
tgtaagaat  ggcattaac  caaaggagg  gtctcggga  aggattagg  tccatcctt  1440
acgtgttta  aaaaaagca  aaaaacatt  taaaaacat  gaaaaattc  gcaaaccat  1500
tttaaagta  aagagggtt  taggtagaa  aacatattc  tgtgctttt  ctgataaag  1560
acagctgta  tggggttct  ggcatctct  tactttgct  gctcatatg  atgtagtca  1620
tttataagt  attgtatgt  attatattc  gtaggtaga  gtgtaacct  ttcacctta  1680
tcatggctg  agtcacctc  tggttacag  agcgtagcg  ggccgtgtg  atgtccttt  1740
cgcctgtga  caccacccc  acaaaccat  cagtgacaa  ccatccagt  gaggtttgt  1800
gggcaccag  cagcgtagc  gggtcggga  aggccacct  tcccactcc  acgatacgc  1860
actataaag  gaagacgaa  tagtgacat  atatattct  tttttatac  cttcctatt  1920
ttgtagtga  ctgtttatg  gatgctggt  ttctaccca  cggccctgc  gccagctca  1980
gtccaggtt  aacccacag  tacttggtt  gtgttcttc  tcatattct  aaaccattc  2040
atttccaag  actttcagt  caataggtg  aggaaatag  gctgttttt  ttgtgtgtg  2100
agggagggc  gttttctaa  ggaatggtt  gggaatatc  atgtacttg  ttgcaagca  2160
gactttgag  caagtgtgg  ccactgtgg  ggcagtgga  gtggggtgt  tgggaggct  2220
cgtgccagt  aagaagaaa  aggtttgca  tctcacatt  ccaggatga  aagttcctt  2280
ccttttctt  aaagaagtt  aagtttagg  atcctttgg  gccaactgg  gtttgaaag  2340
agggacctc  gaggtttac  tagagaaca  gtggttttt  agggttatc  tagatgttt  2400
acaccggaa  gtttttaaa  actaaaata  ataatttat  gttaaggct  aaaagtata  2460
ttattgcag  ggatgttca  aaggccagt  tgatttata  atgcaatct  cccttgatt  2520
aaacacaca  atacacaca  acacacaca  acacacaca  accttctgc  tttgatgtt  2580
cagatttaa  acagtttat  tttaaagat  gatcctttt  taggtgaga  aaaaacaat  2640
tggaagaaa  aaaccacac  aagacattg  ttcagcctg  ttggcgttt  ccagagtca  2700
ctgattgga  aggcatggg  gcaaggaaa  ttagggtac  caacctaag  tcggttccg  2760
tgaattctt  tcccctgcc  cttccttta  aaaacttag  gacaaaata  acaatttgc  2820
catcttggc  atgtaattc  tgtaatttt  atttaggaa  tgttgaagg  aggtggcaa  2880
agtgtggag  ctgacgtgt  agggaggac  ggcgggagg  ggtgtgagg  ggaggctcc  2940
gaggggaag  ggcggtgcc  acaccgggg  caggccgca  ctccatttt  ttattgcgc  3000
gctaccgtt  acttccagg  acggtttgg  aatattcac  tcgcttctg  gtatctctt  3060
cacattgtt  gctgctatt  gaggatcag  tttttgttt  acaatgtca  atactgcca  3120
gtactagtt  tagttttct  ttagaacat  gtattacag  tgccttttt  gtagttttt  3180
tttttttta  gtgatcaat  ttgacttaa  gtgattact  ctctattcc  aaaaggttg  3240
tgtttcaca  tacctcatg  ttcacttag  catggtgga  ccagcgggc  ggttctgcc  3300
gctttggcg  gcagacacg  gggcgcgat  ccacacagg  tggcggggg  cggccccga  3360
gccgcgtgc  tgagaaccg  gccggtgtc  ccagagacc  ggctgtgtc  ctcttctct  3420
ccctgcgcc  gtgatgctg  gcacttcat  tgatcgggg  cgtagcatc  tagtagttt  3480
tacagctgt  ttatwcttt  cgtgtagct  tggaagttg  ataattatt  ttattatta  3540
tataacaag  gtgtcttac  tgccaccac  gcgttgtac  tgtaggact  tcattcggg  3600
tgattggaa  agcttctgg  atttgttca  gttttgggt  tgtttaatc  gttatgtac  3660
agtgttctg  ttgttattg  tttgttaat  acaccataa  gctaattta  agagactcc  3720
aatctcaat  aagccagct  acagtgctg  gtgccccgg  cacctagca  gctgccgaa  3780
caaaagaat  tgcaccccg  tgcgggccc  cgtggttgg  gccctgccc  ggcagggtc  3840
tcctgtgct  ggaggccat  tcgggcaca  gcccacccc  ccccacccc  ccagaacac  3900
gctcacgct  acctcaacc  tcctggctg  ggcgtctgt  tgaaccacg  gggggcctt  3960
agggacgct  tgtctgtcg  gatggggca  gggcacaag  cctggatgt  gtgtgtrtc  4020
agaggccaa  ggctggtgg  aagtgcacg  ggcacagcg  agtctgtcc  gtgacgcgc  4080
agtctgagg  tctgggcgg  gggcggctg  gtctgtgca  ttctggttg  accgcggcg  4140
ttcccagca  caacatgta  ccggcatgt  tccagcaga  gacaaaaag  caaacatga  4200
agtctagaa  taaaactgg  aaaacccca  aaaaaaaaa  aaaa  4244



<210> 1722
<211> 295
<212> PRT
<213> Homo sapiens
<308> P24385
<400> 1722

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
  1               5                  10                  15
Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
             20                  25                  30
Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
         35                  40                  45
Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                 85                  90                  95
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
             100                105                110
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
     130                135                140
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
 145                150                155                160
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                 165                170                175
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
             180                185                190
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
         195                200                205
Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
     210                215                220
Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
 225                230                235                240
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                 245                250                255
Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
             260                265                270
Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
         275                280                285
Asp Val Arg Asp Val Asp Ile 
     290                295



<210> 1723
<211> 3751
<212> DNA
<213> Rattus norvegicus
<308> D14014
<400> 1723

agaaagaga  ctacagact  cgcgcgctc  ggaagaccg  gtcgtagag  tcgagacaa  60
tcccgccag  agcaagaca  gggagaccc  accaggatg  caaccctcc  caggccgcc  120
gctccatgg  acaccagct  ctgtgctgc  aagtggaga  catccgccg  gcgtaccct  180
acaccaatc  cctcaaccg  ccgggtctg  gagccatgc  taagactga  gagacctgc  240
cgccctccg  ttcttactt  aagtgcgtg  agagggaga  tgtgccatc  atgcggaaa  300
tcgtggcca  ctggatgct  gaggtctgc  aggagcaga  gtgcgaaga  gaggtcttc  360
cgctggcca  gaactacct  gaccgtttc  tgtctctgg  gcccctgaa  aagagccgc  420
tgcagcttc  gggggccac  tgcatgttc  tggcctcta  gatgaagga  accattccc  480
tgactgccg  gaagttgtg  atctacact  acaactcta  ccgccccga  gagttgctg  540
aaatggaac  gcttctggt  aacaagctc  aatggaacc  ggccgccat  actccccac  600
atttcatcg  acacttcct  tccaaaatg  cagaggcgg  tgagaacaa  cagatcatc  660
gcaaacatg  acagacctt  gtggccctc  gtgccacag  tgtgaagtt  atttccaac  720
caccctcca  ggtggctgc  gggagtgtg  tggccgcga  gcagggcct  aacctgggc  780
gccccaaca  cttcctctc  tgctaccgc  caacgcact  tctttccag  gtcatcaag  840
gtgacccgg  ctgcctccg  gcctgccag  aacagattg  agcccttct  gagtcaagc  900
tgcgccagg  ccagcagaa  atcgatccc  aggccaccg  ggaggaagg  gaagtggag  960
aagaagctg  tctggcttg  acacccacc  acgtccgag  tgtggacat  tgagggccc  1020
ccgggcagg  gggagtcac  aagtagtgg  atccgcgaa  agaaaggag  cagcccggg  1080
gctcctgac  aggtccccc  tggggatgt  ttgttacca  aaggggaag  tttgttctc  1140
ttgttggtt  tttttcctt  atctttctc  tttctatct  atttaagca  aagagaaaa  1200
aatacctga  agctgtctt  aagagagag  gagagatag  attcgcatc  ccctgagta  1260
agggagacg  gggggtgcc  acaaaaata  aattctgta  cccagtaat  aactagttt  1320
ctattaatg  gcttgtctg  tctaagaat  ggattaaca  acaggaagt  ttgagaagg  1380
tttttgatt  ttttatgtg  ttaagaaaa  aaagcttaa  aaacattgc  ttaaaaaaa  1440
aaggaaaaa  aatacagca  accattgtt  aagtagaag  gttttaggt  gagaaatgt  1500
ctctgcttt  gtgaaaagg  acagatttg  gaaggtcct  aacctcact  ccctgcttg  1560
tcagtgcct  cagacctgt  acctgatga  acctgtgct  tatcccagg  gtggggcag  1620
cctcttaac  ttactgatg  tcgattcga  ctctagcgg  ctcgtgggt  tggcaacct  1680
cagggctca  gttatgggc  ctctgcccc  cacaacctg  aggttcaca  agcgccagc  1740
agcacgcag  ggtagggat  aaatagtga  ataatatat  ctatttttg  ggaaccttc  1800
tgttttggg  gttcctgtt  agagagatg  tggtttttg  ctggtggcc  tgcagccca  1860
tcaacatca  gttgaaccc  cagcttttc  tttgtgtgt  gtttgtttt  ttatgtttt  1920
ccttctcca  gttcccaaa  ccattccat  tcaaagcac  tttggtcag  tagctggag  1980
cagtgttgc  gggtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtcgg  2040
gggggaggg  gtctagtgg  atggttggg  atgtccaca  actcaattc  gatggctgc  2100
cagcaggtg  gtagggctg  tagcatgag  tgcttggga  gttgtgttg  gtcgagaag  2160
gaaagctct  ttctcgtac  accgggatc  tcctgcaaa  tcggaggga  cttttggtg  2220
cagctggcg  ttggaagta  ggaccgtga  ggcattacc  ggacaaggg  attcaggac  2280
actcttaag  ctttcacac  ggaggcttt  aaacactaa  atctctaat  tatacgtaa  2340
gctacagaa  agtatttat  gggaaggtt  cccatgacc  gtgtgactc  aagcaatgt  2400
atcttccct  gattcaaac  cacaccttc  tccctgctg  cgaaggttt  aggccattg  2460
ctgagagac  ggtctttta  tggccaagt  gggtgtcct  caaaaaaac  aaaccacaa  2520
gacggagat  tgggtctcc  tgactttcc  aacccaatt  cccccattg  agagccatc  2580
aaacctgag  aaaattagg  gaccccaaa  gagtcttga  tctggcaca  tcttgccgc  2640
gctcccaag  tagcaacag  aggtaattt  cacacctct  gctctgtgc  tttctgttc  2700
ggatgtgtt  gtgggaggt  gagagcggg  ggctggaga  gggatgtga  agaagaagt  2760
tggagggta  ggaccacac  ggacagacc  cggctcctt  cacagcgct  ctaccaatg  2820
ctcccagga  ccccggcgt  cggaaccag  ttcacgttg  tttgtatct  tcatgttgt  2880
ttcgctgct  ttggagggt  agttttatt  tgttgttgt  ggtttgttt  ttttttttt  2940
caatgtcat  aactgccat  ttcaagttt  aatttcctc  tagaagagt  tatttacag  3000
tgccctctc  gggactttt  ctatttatt  tgattcaat  ttggattaa  gtgattacc  3060
ctgtattcc  aacaaaagg  gttttccac  cacacacac  cacacacac  cacacacac  3120
cacacacac  ggttcctgt  cacaatacc  catgtatca  ctaacaata  ataggcctg  3180
caggcgggt  gggcggtct  cctccaggg  ccctgggac  ctgctgggg  tcatcctgt  3240
atgctgggc  ttcatttga  ctgggacat  gcatcacag  agtcaggcc  actgtgttc  3300
gttagttat  aatattgtt  cttgtagcg  cctgttgtg  atgccacca  gctgctgga  3360
ccggagaga  ttgttctga  tctctggtg  atcatataa  ctgttaggt  ctagtgttc  3420
gtcttgttt  gtgttactc  cagcattgt  ctaatgtaa  gccagccgc  atgctgtag  3480
ccccaggtt  cctagcaag  tgccaaacc  aaagggtca  caccagctt  gctgaggcg  3540
cccaaccag  caggaccct  gagggctgc  gtgtccatg  tgatggggt  aagttttgg  3600
caaagggcc  aaggctggt  gatccacac  gtctgccct  tgacatgaa  ggctttgag  3660
ggctctggc  ggtggtcag  ttggctttg  gtattctgg  tgacacacc  tggcgcttc  3720
cagcacaga  atgtgacca  catggtcca  g  3751



<210> 1724
<211> 295
<212> PRT
<213> Rattus norvegicus
<308> BAA03115
<400> 1724

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
  1               5                  10                  15
Tyr Pro Asp Thr Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
             20                  25                  30
Lys Thr Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
         35                  40                  45
Gln Arg Glu Ile Val Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Leu Lys Lys 
                 85                  90                  95
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
             100                105                110
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
     130                135                140
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
 145                150                155                160
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Asp Glu Asn Lys Gln 
                 165                170                175
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
             180                185                190
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
         195                200                205
Val Ala Ala Met Gln Gly Leu Asn Leu Gly Ser Pro Asn Asn Phe Leu 
     210                215                220
Ser Cys Tyr Arg Thr Thr His Phe Leu Ser Arg Val Ile Lys Cys Asp 
 225                230                235                240
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                 245                250                255
Ser Ser Leu Arg Gln Ala Gln Gln Asn Ile Asp Pro Lys Ala Thr Glu 
             260                265                270
Glu Glu Gly Glu Val Glu Glu Glu Ala Gly Leu Ala Cys Thr Pro Thr 
         275                280                285
Asp Val Arg Asp Val Asp Ile 
     290                295



<210> 1725
<211> 4244
<212> DNA
<213> Homo sapiens
<308> X59798
<400> 1725

ggcgcagta  cagcgagca  cagagtccg  acgctccgg  gaggggcag  agagcgcga  60
ggagcgcgg  gcagcagaa  cgagagccg  gcgcggacc  agccaggac  cacagccct  120
cccagctgc  caggaagag  cccagccat  gaacaccag  tcctgtgct  cgaagtgga  180
accatccgc  gcgcgtacc  cgatgccaa  ctcctcaac  accgggtgc  gcgggccat  240
ctgaaggcg  aggagacct  cgcgccctc  gtgtcctac  tcaaatgtg  gcagaagga  300
gtcctgccg  ccatgcgga  gatcgtcgc  acctggatg  tggaggtct  cgaggaaca  360
aagtgcgag  aggaggtct  cccgctggc  atgaactac  tggaccgct  cctgtcgct  420
gagcccgtg  aaaagagcc  cctgcagct  ctgggggcc  cttgcatgt  cgtggcctc  480
aagatgaag  agaccatcc  cctgacggc  gagaagctg  gcatctaca  cgacaactc  540
atccggccc  aggagctgc  gcaaatgga  ctgctcctg  tgaacaagc  caagtggaa  600
ctggccgca  tgaccccgc  cgatttcat  gaacacttc  tctccaaaa  gccagaggc  660
gaggagaac  aacagatca  ccgcaaaca  gcgcagacc  tcgttgccc  ctgtgccac  720
gatgtgaag  tcatttcca  tccgccctc  atggtggca  cggggagcg  ggtggccgc  780
gtgcaaggc  tgaacctga  gagccccaa  aacttcctg  cctactacc  cctcacacg  840
ttcctctcc  gagtgatca  gtgtgaccc  gactgcctc  gggcctgcc  ggagcagat  900
gaagccctg  tggagtcaa  cctgcgcca  gcccagcag  acatggacc  caaggccgc  960
gaggaggag  aagaggagg  ggaggaggt  gacctggct  gcacaccca  cgacgtgcg  1020
gacgtggac  tctgagggc  ccaggcagg  gggcgccac  gccacccgc  gcgagggcg  1080
agccggccc  aggtgctcc  ctgacagtc  ctcctctcc  gagcatttt  ataccagaa  1140
ggaaagctt  attctcctt  ttgttggtt  ttttttcct  tgctctttc  cccttccat  1200
tctgactta  gcaaaagaa  aagattacc  aaaaactgt  tttaaaaga  agagagaga  1260
aaaaaaaat  gtatttgca  aaccctgag  ggtggggga  gagggttgt  ctacagatg  1320
tagaggatt  tatacccca  taatcaact  gtttttata  taatgtact  gtttctctg  1380
tgtaagaat  ggcattaac  caaaggagg  gtctcggga  aggattagg  tccatcctt  1440
acgtgttta  aaaaaagca  aaaaacatt  taaaaacat  gaaaaattc  gcaaaccat  1500
tttaaagta  aagagggtt  taggtagaa  aacatattc  tgtgctttt  ctgataaag  1560
acagctgta  tggggttct  ggcatctct  tactttgct  gctcatatg  atgtagtca  1620
tttataagt  attgtatgt  attatattc  gtaggtaga  gtgtaacct  ttcacctta  1680
tcatggctg  agtcacctc  tggttacag  agcgtagcg  ggccgtgtg  atgtccttt  1740
cgcctgtga  caccacccc  acaaaccat  cagtgacaa  ccatccagt  gaggtttgt  1800
gggcaccag  cagcgtagc  gggtcggga  aggccacct  tcccactcc  acgatacgc  1860
actataaag  gaagacgaa  tagtgacat  atatattct  tttttatac  cttcctatt  1920
ttgtagtga  ctgtttatg  gatgctggt  ttctaccca  cggccctgc  gccagctca  1980
gtccaggtt  aacccacag  tacttggtt  gtgttcttc  tcatattct  aaaccattc  2040
atttccaag  actttcagt  caataggtg  aggaaatag  gctgttttt  ttgtgtgtg  2100
agggagggc  gttttctaa  ggaatggtt  gggaatatc  atgtacttg  ttgcaagca  2160
gactttgag  caagtgtgg  ccactgtgg  ggcagtgga  gtggggtgt  tgggaggct  2220
cgtgccagt  aagaagaaa  aggtttgca  tctcacatt  ccaggatga  aagttcctt  2280
ccttttctt  aaagaagtt  aagtttagg  atcctttgg  gccaactgg  gtttgaaag  2340
agggacctc  gaggtttac  tagagaaca  gtggttttt  agggttatc  tagatgttt  2400
acaccggaa  gtttttaaa  actaaaata  ataatttat  gttaaggct  aaaagtata  2460
ttattgcag  ggatgttca  aaggccagt  tgatttata  atgcaatct  cccttgatt  2520
aaacacaca  atacacaca  acacacaca  acacacaca  accttctgc  tttgatgtt  2580
cagatttaa  acagtttat  tttaaagat  gatcctttt  taggtgaga  aaaaacaat  2640
tggaagaaa  aaaccacac  aagacattg  ttcagcctg  ttggcgttt  ccagagtca  2700
ctgattgga  aggcatggg  gcaaggaaa  ttagggtac  caacctaag  tcggttccg  2760
tgaattctt  tcccctgcc  cttccttta  aaaacttag  gacaaaata  acaatttgc  2820
catcttggc  atgtaattc  tgtaatttt  atttaggaa  tgttgaagg  aggtggcaa  2880
agtgtggag  ctgacgtgt  agggaggac  ggcgggagg  ggtgtgagg  ggaggctcc  2940
gaggggaag  ggcggtgcc  acaccgggg  caggccgca  ctccatttt  ttattgcgc  3000
gctaccgtt  acttccagg  acggtttgg  aatattcac  tcgcttctg  gtatctctt  3060
cacattgtt  gctgctatt  gaggatcag  tttttgttt  acaatgtca  atactgcca  3120
gtactagtt  tagttttct  ttagaacat  gtattacag  tgccttttt  gtagttttt  3180
tttttttta  gtgatcaat  ttgacttaa  gtgattact  ctctattcc  aaaaggttg  3240
tgtttcaca  tacctcatg  ttcacttag  catggtgga  ccagcgggc  ggttctgcc  3300
gctttggcg  gcagacacg  gggcgcgat  ccacacagg  tggcggggg  cggccccga  3360
gccgcgtgc  tgagaaccg  gccggtgtc  ccagagacc  ggctgtgtc  ctcttctct  3420
ccctgcgcc  gtgatgctg  gcacttcat  tgatcgggg  cgtagcatc  tagtagttt  3480
tacagctgt  ttatwcttt  cgtgtagct  tggaagttg  ataattatt  ttattatta  3540
tataacaag  gtgtcttac  tgccaccac  gcgttgtac  tgtaggact  tcattcggg  3600
tgattggaa  agcttctgg  atttgttca  gttttgggt  tgtttaatc  gttatgtac  3660
agtgttctg  ttgttattg  tttgttaat  acaccataa  gctaattta  agagactcc  3720
aatctcaat  aagccagct  acagtgctg  gtgccccgg  cacctagca  gctgccgaa  3780
caaaagaat  tgcaccccg  tgcgggccc  cgtggttgg  gccctgccc  ggcagggtc  3840
tcctgtgct  ggaggccat  tcgggcaca  gcccacccc  ccccacccc  ccagaacac  3900
gctcacgct  acctcaacc  tcctggctg  ggcgtctgt  tgaaccacg  gggggcctt  3960
agggacgct  tgtctgtcg  gatggggca  gggcacaag  cctggatgt  gtgtgtrtc  4020
agaggccaa  ggctggtgg  aagtgcacg  ggcacagcg  agtctgtcc  gtgacgcgc  4080
agtctgagg  tctgggcgg  gggcggctg  gtctgtgca  ttctggttg  accgcggcg  4140
ttcccagca  caacatgta  ccggcatgt  tccagcaga  gacaaaaag  caaacatga  4200
agtctagaa  taaaactgg  aaaacccca  aaaaaaaaa  aaaa  4244



<210> 1726
<211> 295
<212> PRT
<213> Homo sapiens
<308> P24385
<400> 1726

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
  1               5                  10                  15
Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
             20                  25                  30
Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
         35                  40                  45
Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                 85                  90                  95
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
             100                105                110
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
     130                135                140
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
 145                150                155                160
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                 165                170                175
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
             180                185                190
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
         195                200                205
Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
     210                215                220
Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
 225                230                235                240
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                 245                250                255
Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
             260                265                270
Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
         275                280                285
Asp Val Arg Asp Val Asp Ile 
     290                295



<210> 1727
<211> 3751
<212> DNA
<213> Rattus norvegicus
<308> D14014
<400> 1727

agaaagaga  ctacagact  cgcgcgctc  ggaagaccg  gtcgtagag  tcgagacaa  60
tcccgccag  agcaagaca  gggagaccc  accaggatg  caaccctcc  caggccgcc  120
gctccatgg  acaccagct  ctgtgctgc  aagtggaga  catccgccg  gcgtaccct  180
acaccaatc  cctcaaccg  ccgggtctg  gagccatgc  taagactga  gagacctgc  240
cgccctccg  ttcttactt  aagtgcgtg  agagggaga  tgtgccatc  atgcggaaa  300
tcgtggcca  ctggatgct  gaggtctgc  aggagcaga  gtgcgaaga  gaggtcttc  360
cgctggcca  gaactacct  gaccgtttc  tgtctctgg  gcccctgaa  aagagccgc  420
tgcagcttc  gggggccac  tgcatgttc  tggcctcta  gatgaagga  accattccc  480
tgactgccg  gaagttgtg  atctacact  acaactcta  ccgccccga  gagttgctg  540
aaatggaac  gcttctggt  aacaagctc  aatggaacc  ggccgccat  actccccac  600
atttcatcg  acacttcct  tccaaaatg  cagaggcgg  tgagaacaa  cagatcatc  660
gcaaacatg  acagacctt  gtggccctc  gtgccacag  tgtgaagtt  atttccaac  720
caccctcca  ggtggctgc  gggagtgtg  tggccgcga  gcagggcct  aacctgggc  780
gccccaaca  cttcctctc  tgctaccgc  caacgcact  tctttccag  gtcatcaag  840
gtgacccgg  ctgcctccg  gcctgccag  aacagattg  agcccttct  gagtcaagc  900
tgcgccagg  ccagcagaa  atcgatccc  aggccaccg  ggaggaagg  gaagtggag  960
aagaagctg  tctggcttg  acacccacc  acgtccgag  tgtggacat  tgagggccc  1020
ccgggcagg  gggagtcac  aagtagtgg  atccgcgaa  agaaaggag  cagcccggg  1080
gctcctgac  aggtccccc  tggggatgt  ttgttacca  aaggggaag  tttgttctc  1140
ttgttggtt  tttttcctt  atctttctc  tttctatct  atttaagca  aagagaaaa  1200
aatacctga  agctgtctt  aagagagag  gagagatag  attcgcatc  ccctgagta  1260
agggagacg  gggggtgcc  acaaaaata  aattctgta  cccagtaat  aactagttt  1320
ctattaatg  gcttgtctg  tctaagaat  ggattaaca  acaggaagt  ttgagaagg  1380
tttttgatt  ttttatgtg  ttaagaaaa  aaagcttaa  aaacattgc  ttaaaaaaa  1440
aaggaaaaa  aatacagca  accattgtt  aagtagaag  gttttaggt  gagaaatgt  1500
ctctgcttt  gtgaaaagg  acagatttg  gaaggtcct  aacctcact  ccctgcttg  1560
tcagtgcct  cagacctgt  acctgatga  acctgtgct  tatcccagg  gtggggcag  1620
cctcttaac  ttactgatg  tcgattcga  ctctagcgg  ctcgtgggt  tggcaacct  1680
cagggctca  gttatgggc  ctctgcccc  cacaacctg  aggttcaca  agcgccagc  1740
agcacgcag  ggtagggat  aaatagtga  ataatatat  ctatttttg  ggaaccttc  1800
tgttttggg  gttcctgtt  agagagatg  tggtttttg  ctggtggcc  tgcagccca  1860
tcaacatca  gttgaaccc  cagcttttc  tttgtgtgt  gtttgtttt  ttatgtttt  1920
ccttctcca  gttcccaaa  ccattccat  tcaaagcac  tttggtcag  tagctggag  1980
cagtgttgc  gggtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtcgg  2040
gggggaggg  gtctagtgg  atggttggg  atgtccaca  actcaattc  gatggctgc  2100
cagcaggtg  gtagggctg  tagcatgag  tgcttggga  gttgtgttg  gtcgagaag  2160
gaaagctct  ttctcgtac  accgggatc  tcctgcaaa  tcggaggga  cttttggtg  2220
cagctggcg  ttggaagta  ggaccgtga  ggcattacc  ggacaaggg  attcaggac  2280
actcttaag  ctttcacac  ggaggcttt  aaacactaa  atctctaat  tatacgtaa  2340
gctacagaa  agtatttat  gggaaggtt  cccatgacc  gtgtgactc  aagcaatgt  2400
atcttccct  gattcaaac  cacaccttc  tccctgctg  cgaaggttt  aggccattg  2460
ctgagagac  ggtctttta  tggccaagt  gggtgtcct  caaaaaaac  aaaccacaa  2520
gacggagat  tgggtctcc  tgactttcc  aacccaatt  cccccattg  agagccatc  2580
aaacctgag  aaaattagg  gaccccaaa  gagtcttga  tctggcaca  tcttgccgc  2640
gctcccaag  tagcaacag  aggtaattt  cacacctct  gctctgtgc  tttctgttc  2700
ggatgtgtt  gtgggaggt  gagagcggg  ggctggaga  gggatgtga  agaagaagt  2760
tggagggta  ggaccacac  ggacagacc  cggctcctt  cacagcgct  ctaccaatg  2820
ctcccagga  ccccggcgt  cggaaccag  ttcacgttg  tttgtatct  tcatgttgt  2880
ttcgctgct  ttggagggt  agttttatt  tgttgttgt  ggtttgttt  ttttttttt  2940
caatgtcat  aactgccat  ttcaagttt  aatttcctc  tagaagagt  tatttacag  3000
tgccctctc  gggactttt  ctatttatt  tgattcaat  ttggattaa  gtgattacc  3060
ctgtattcc  aacaaaagg  gttttccac  cacacacac  cacacacac  cacacacac  3120
cacacacac  ggttcctgt  cacaatacc  catgtatca  ctaacaata  ataggcctg  3180
caggcgggt  gggcggtct  cctccaggg  ccctgggac  ctgctgggg  tcatcctgt  3240
atgctgggc  ttcatttga  ctgggacat  gcatcacag  agtcaggcc  actgtgttc  3300
gttagttat  aatattgtt  cttgtagcg  cctgttgtg  atgccacca  gctgctgga  3360
ccggagaga  ttgttctga  tctctggtg  atcatataa  ctgttaggt  ctagtgttc  3420
gtcttgttt  gtgttactc  cagcattgt  ctaatgtaa  gccagccgc  atgctgtag  3480
ccccaggtt  cctagcaag  tgccaaacc  aaagggtca  caccagctt  gctgaggcg  3540
cccaaccag  caggaccct  gagggctgc  gtgtccatg  tgatggggt  aagttttgg  3600
caaagggcc  aaggctggt  gatccacac  gtctgccct  tgacatgaa  ggctttgag  3660
ggctctggc  ggtggtcag  ttggctttg  gtattctgg  tgacacacc  tggcgcttc  3720
cagcacaga  atgtgacca  catggtcca  g  3751



<210> 1728
<211> 295
<212> PRT
<213> Rattus norvegicus
<308> BAA03115
<400> 1728

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
  1               5                  10                  15
Tyr Pro Asp Thr Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
             20                  25                  30
Lys Thr Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
         35                  40                  45
Gln Arg Glu Ile Val Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Leu Lys Lys 
                 85                  90                  95
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
             100                105                110
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
     130                135                140
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
 145                150                155                160
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Asp Glu Asn Lys Gln 
                 165                170                175
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
             180                185                190
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
         195                200                205
Val Ala Ala Met Gln Gly Leu Asn Leu Gly Ser Pro Asn Asn Phe Leu 
     210                215                220
Ser Cys Tyr Arg Thr Thr His Phe Leu Ser Arg Val Ile Lys Cys Asp 
 225                230                235                240
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                 245                250                255
Ser Ser Leu Arg Gln Ala Gln Gln Asn Ile Asp Pro Lys Ala Thr Glu 
             260                265                270
Glu Glu Gly Glu Val Glu Glu Glu Ala Gly Leu Ala Cys Thr Pro Thr 
         275                280                285
Asp Val Arg Asp Val Asp Ile 
     290                295



<210> 1729
<211> 4244
<212> DNA
<213> Homo sapiens
<308> X59798
<400> 1729

ggcgcagta  cagcgagca  cagagtccg  acgctccgg  gaggggcag  agagcgcga  60
ggagcgcgg  gcagcagaa  cgagagccg  gcgcggacc  agccaggac  cacagccct  120
cccagctgc  caggaagag  cccagccat  gaacaccag  tcctgtgct  cgaagtgga  180
accatccgc  gcgcgtacc  cgatgccaa  ctcctcaac  accgggtgc  gcgggccat  240
ctgaaggcg  aggagacct  cgcgccctc  gtgtcctac  tcaaatgtg  gcagaagga  300
gtcctgccg  ccatgcgga  gatcgtcgc  acctggatg  tggaggtct  cgaggaaca  360
aagtgcgag  aggaggtct  cccgctggc  atgaactac  tggaccgct  cctgtcgct  420
gagcccgtg  aaaagagcc  cctgcagct  ctgggggcc  cttgcatgt  cgtggcctc  480
aagatgaag  agaccatcc  cctgacggc  gagaagctg  gcatctaca  cgacaactc  540
atccggccc  aggagctgc  gcaaatgga  ctgctcctg  tgaacaagc  caagtggaa  600
ctggccgca  tgaccccgc  cgatttcat  gaacacttc  tctccaaaa  gccagaggc  660
gaggagaac  aacagatca  ccgcaaaca  gcgcagacc  tcgttgccc  ctgtgccac  720
gatgtgaag  tcatttcca  tccgccctc  atggtggca  cggggagcg  ggtggccgc  780
gtgcaaggc  tgaacctga  gagccccaa  aacttcctg  cctactacc  cctcacacg  840
ttcctctcc  gagtgatca  gtgtgaccc  gactgcctc  gggcctgcc  ggagcagat  900
gaagccctg  tggagtcaa  cctgcgcca  gcccagcag  acatggacc  caaggccgc  960
gaggaggag  aagaggagg  ggaggaggt  gacctggct  gcacaccca  cgacgtgcg  1020
gacgtggac  tctgagggc  ccaggcagg  gggcgccac  gccacccgc  gcgagggcg  1080
agccggccc  aggtgctcc  ctgacagtc  ctcctctcc  gagcatttt  ataccagaa  1140
ggaaagctt  attctcctt  ttgttggtt  ttttttcct  tgctctttc  cccttccat  1200
tctgactta  gcaaaagaa  aagattacc  aaaaactgt  tttaaaaga  agagagaga  1260
aaaaaaaat  gtatttgca  aaccctgag  ggtggggga  gagggttgt  ctacagatg  1320
tagaggatt  tatacccca  taatcaact  gtttttata  taatgtact  gtttctctg  1380
tgtaagaat  ggcattaac  caaaggagg  gtctcggga  aggattagg  tccatcctt  1440
acgtgttta  aaaaaagca  aaaaacatt  taaaaacat  gaaaaattc  gcaaaccat  1500
tttaaagta  aagagggtt  taggtagaa  aacatattc  tgtgctttt  ctgataaag  1560
acagctgta  tggggttct  ggcatctct  tactttgct  gctcatatg  atgtagtca  1620
tttataagt  attgtatgt  attatattc  gtaggtaga  gtgtaacct  ttcacctta  1680
tcatggctg  agtcacctc  tggttacag  agcgtagcg  ggccgtgtg  atgtccttt  1740
cgcctgtga  caccacccc  acaaaccat  cagtgacaa  ccatccagt  gaggtttgt  1800
gggcaccag  cagcgtagc  gggtcggga  aggccacct  tcccactcc  acgatacgc  1860
actataaag  gaagacgaa  tagtgacat  atatattct  tttttatac  cttcctatt  1920
ttgtagtga  ctgtttatg  gatgctggt  ttctaccca  cggccctgc  gccagctca  1980
gtccaggtt  aacccacag  tacttggtt  gtgttcttc  tcatattct  aaaccattc  2040
atttccaag  actttcagt  caataggtg  aggaaatag  gctgttttt  ttgtgtgtg  2100
agggagggc  gttttctaa  ggaatggtt  gggaatatc  atgtacttg  ttgcaagca  2160
gactttgag  caagtgtgg  ccactgtgg  ggcagtgga  gtggggtgt  tgggaggct  2220
cgtgccagt  aagaagaaa  aggtttgca  tctcacatt  ccaggatga  aagttcctt  2280
ccttttctt  aaagaagtt  aagtttagg  atcctttgg  gccaactgg  gtttgaaag  2340
agggacctc  gaggtttac  tagagaaca  gtggttttt  agggttatc  tagatgttt  2400
acaccggaa  gtttttaaa  actaaaata  ataatttat  gttaaggct  aaaagtata  2460
ttattgcag  ggatgttca  aaggccagt  tgatttata  atgcaatct  cccttgatt  2520
aaacacaca  atacacaca  acacacaca  acacacaca  accttctgc  tttgatgtt  2580
cagatttaa  acagtttat  tttaaagat  gatcctttt  taggtgaga  aaaaacaat  2640
tggaagaaa  aaaccacac  aagacattg  ttcagcctg  ttggcgttt  ccagagtca  2700
ctgattgga  aggcatggg  gcaaggaaa  ttagggtac  caacctaag  tcggttccg  2760
tgaattctt  tcccctgcc  cttccttta  aaaacttag  gacaaaata  acaatttgc  2820
catcttggc  atgtaattc  tgtaatttt  atttaggaa  tgttgaagg  aggtggcaa  2880
agtgtggag  ctgacgtgt  agggaggac  ggcgggagg  ggtgtgagg  ggaggctcc  2940
gaggggaag  ggcggtgcc  acaccgggg  caggccgca  ctccatttt  ttattgcgc  3000
gctaccgtt  acttccagg  acggtttgg  aatattcac  tcgcttctg  gtatctctt  3060
cacattgtt  gctgctatt  gaggatcag  tttttgttt  acaatgtca  atactgcca  3120
gtactagtt  tagttttct  ttagaacat  gtattacag  tgccttttt  gtagttttt  3180
tttttttta  gtgatcaat  ttgacttaa  gtgattact  ctctattcc  aaaaggttg  3240
tgtttcaca  tacctcatg  ttcacttag  catggtgga  ccagcgggc  ggttctgcc  3300
gctttggcg  gcagacacg  gggcgcgat  ccacacagg  tggcggggg  cggccccga  3360
gccgcgtgc  tgagaaccg  gccggtgtc  ccagagacc  ggctgtgtc  ctcttctct  3420
ccctgcgcc  gtgatgctg  gcacttcat  tgatcgggg  cgtagcatc  tagtagttt  3480
tacagctgt  ttatwcttt  cgtgtagct  tggaagttg  ataattatt  ttattatta  3540
tataacaag  gtgtcttac  tgccaccac  gcgttgtac  tgtaggact  tcattcggg  3600
tgattggaa  agcttctgg  atttgttca  gttttgggt  tgtttaatc  gttatgtac  3660
agtgttctg  ttgttattg  tttgttaat  acaccataa  gctaattta  agagactcc  3720
aatctcaat  aagccagct  acagtgctg  gtgccccgg  cacctagca  gctgccgaa  3780
caaaagaat  tgcaccccg  tgcgggccc  cgtggttgg  gccctgccc  ggcagggtc  3840
tcctgtgct  ggaggccat  tcgggcaca  gcccacccc  ccccacccc  ccagaacac  3900
gctcacgct  acctcaacc  tcctggctg  ggcgtctgt  tgaaccacg  gggggcctt  3960
agggacgct  tgtctgtcg  gatggggca  gggcacaag  cctggatgt  gtgtgtrtc  4020
agaggccaa  ggctggtgg  aagtgcacg  ggcacagcg  agtctgtcc  gtgacgcgc  4080
agtctgagg  tctgggcgg  gggcggctg  gtctgtgca  ttctggttg  accgcggcg  4140
ttcccagca  caacatgta  ccggcatgt  tccagcaga  gacaaaaag  caaacatga  4200
agtctagaa  taaaactgg  aaaacccca  aaaaaaaaa  aaaa  4244



<210> 1730
<211> 295
<212> PRT
<213> Homo sapiens
<308> P24385
<400> 1730

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
  1               5                  10                  15
Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
             20                  25                  30
Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
         35                  40                  45
Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                 85                  90                  95
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
             100                105                110
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
     130                135                140
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
 145                150                155                160
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                 165                170                175
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
             180                185                190
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
         195                200                205
Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
     210                215                220
Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
 225                230                235                240
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                 245                250                255
Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
             260                265                270
Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
         275                280                285
Asp Val Arg Asp Val Asp Ile 
     290                295



<210> 1731
<211> 3751
<212> DNA
<213> Rattus norvegicus
<308> D14014
<400> 1731

agaaagaga  ctacagact  cgcgcgctc  ggaagaccg  gtcgtagag  tcgagacaa  60
tcccgccag  agcaagaca  gggagaccc  accaggatg  caaccctcc  caggccgcc  120
gctccatgg  acaccagct  ctgtgctgc  aagtggaga  catccgccg  gcgtaccct  180
acaccaatc  cctcaaccg  ccgggtctg  gagccatgc  taagactga  gagacctgc  240
cgccctccg  ttcttactt  aagtgcgtg  agagggaga  tgtgccatc  atgcggaaa  300
tcgtggcca  ctggatgct  gaggtctgc  aggagcaga  gtgcgaaga  gaggtcttc  360
cgctggcca  gaactacct  gaccgtttc  tgtctctgg  gcccctgaa  aagagccgc  420
tgcagcttc  gggggccac  tgcatgttc  tggcctcta  gatgaagga  accattccc  480
tgactgccg  gaagttgtg  atctacact  acaactcta  ccgccccga  gagttgctg  540
aaatggaac  gcttctggt  aacaagctc  aatggaacc  ggccgccat  actccccac  600
atttcatcg  acacttcct  tccaaaatg  cagaggcgg  tgagaacaa  cagatcatc  660
gcaaacatg  acagacctt  gtggccctc  gtgccacag  tgtgaagtt  atttccaac  720
caccctcca  ggtggctgc  gggagtgtg  tggccgcga  gcagggcct  aacctgggc  780
gccccaaca  cttcctctc  tgctaccgc  caacgcact  tctttccag  gtcatcaag  840
gtgacccgg  ctgcctccg  gcctgccag  aacagattg  agcccttct  gagtcaagc  900
tgcgccagg  ccagcagaa  atcgatccc  aggccaccg  ggaggaagg  gaagtggag  960
aagaagctg  tctggcttg  acacccacc  acgtccgag  tgtggacat  tgagggccc  1020
ccgggcagg  gggagtcac  aagtagtgg  atccgcgaa  agaaaggag  cagcccggg  1080
gctcctgac  aggtccccc  tggggatgt  ttgttacca  aaggggaag  tttgttctc  1140
ttgttggtt  tttttcctt  atctttctc  tttctatct  atttaagca  aagagaaaa  1200
aatacctga  agctgtctt  aagagagag  gagagatag  attcgcatc  ccctgagta  1260
agggagacg  gggggtgcc  acaaaaata  aattctgta  cccagtaat  aactagttt  1320
ctattaatg  gcttgtctg  tctaagaat  ggattaaca  acaggaagt  ttgagaagg  1380
tttttgatt  ttttatgtg  ttaagaaaa  aaagcttaa  aaacattgc  ttaaaaaaa  1440
aaggaaaaa  aatacagca  accattgtt  aagtagaag  gttttaggt  gagaaatgt  1500
ctctgcttt  gtgaaaagg  acagatttg  gaaggtcct  aacctcact  ccctgcttg  1560
tcagtgcct  cagacctgt  acctgatga  acctgtgct  tatcccagg  gtggggcag  1620
cctcttaac  ttactgatg  tcgattcga  ctctagcgg  ctcgtgggt  tggcaacct  1680
cagggctca  gttatgggc  ctctgcccc  cacaacctg  aggttcaca  agcgccagc  1740
agcacgcag  ggtagggat  aaatagtga  ataatatat  ctatttttg  ggaaccttc  1800
tgttttggg  gttcctgtt  agagagatg  tggtttttg  ctggtggcc  tgcagccca  1860
tcaacatca  gttgaaccc  cagcttttc  tttgtgtgt  gtttgtttt  ttatgtttt  1920
ccttctcca  gttcccaaa  ccattccat  tcaaagcac  tttggtcag  tagctggag  1980
cagtgttgc  gggtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtcgg  2040
gggggaggg  gtctagtgg  atggttggg  atgtccaca  actcaattc  gatggctgc  2100
cagcaggtg  gtagggctg  tagcatgag  tgcttggga  gttgtgttg  gtcgagaag  2160
gaaagctct  ttctcgtac  accgggatc  tcctgcaaa  tcggaggga  cttttggtg  2220
cagctggcg  ttggaagta  ggaccgtga  ggcattacc  ggacaaggg  attcaggac  2280
actcttaag  ctttcacac  ggaggcttt  aaacactaa  atctctaat  tatacgtaa  2340
gctacagaa  agtatttat  gggaaggtt  cccatgacc  gtgtgactc  aagcaatgt  2400
atcttccct  gattcaaac  cacaccttc  tccctgctg  cgaaggttt  aggccattg  2460
ctgagagac  ggtctttta  tggccaagt  gggtgtcct  caaaaaaac  aaaccacaa  2520
gacggagat  tgggtctcc  tgactttcc  aacccaatt  cccccattg  agagccatc  2580
aaacctgag  aaaattagg  gaccccaaa  gagtcttga  tctggcaca  tcttgccgc  2640
gctcccaag  tagcaacag  aggtaattt  cacacctct  gctctgtgc  tttctgttc  2700
ggatgtgtt  gtgggaggt  gagagcggg  ggctggaga  gggatgtga  agaagaagt  2760
tggagggta  ggaccacac  ggacagacc  cggctcctt  cacagcgct  ctaccaatg  2820
ctcccagga  ccccggcgt  cggaaccag  ttcacgttg  tttgtatct  tcatgttgt  2880
ttcgctgct  ttggagggt  agttttatt  tgttgttgt  ggtttgttt  ttttttttt  2940
caatgtcat  aactgccat  ttcaagttt  aatttcctc  tagaagagt  tatttacag  3000
tgccctctc  gggactttt  ctatttatt  tgattcaat  ttggattaa  gtgattacc  3060
ctgtattcc  aacaaaagg  gttttccac  cacacacac  cacacacac  cacacacac  3120
cacacacac  ggttcctgt  cacaatacc  catgtatca  ctaacaata  ataggcctg  3180
caggcgggt  gggcggtct  cctccaggg  ccctgggac  ctgctgggg  tcatcctgt  3240
atgctgggc  ttcatttga  ctgggacat  gcatcacag  agtcaggcc  actgtgttc  3300
gttagttat  aatattgtt  cttgtagcg  cctgttgtg  atgccacca  gctgctgga  3360
ccggagaga  ttgttctga  tctctggtg  atcatataa  ctgttaggt  ctagtgttc  3420
gtcttgttt  gtgttactc  cagcattgt  ctaatgtaa  gccagccgc  atgctgtag  3480
ccccaggtt  cctagcaag  tgccaaacc  aaagggtca  caccagctt  gctgaggcg  3540
cccaaccag  caggaccct  gagggctgc  gtgtccatg  tgatggggt  aagttttgg  3600
caaagggcc  aaggctggt  gatccacac  gtctgccct  tgacatgaa  ggctttgag  3660
ggctctggc  ggtggtcag  ttggctttg  gtattctgg  tgacacacc  tggcgcttc  3720
cagcacaga  atgtgacca  catggtcca  g  3751



<210> 1732
<211> 295
<212> PRT
<213> Rattus norvegicus
<308> BAA03115
<400> 1732

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
  1               5                  10                  15
Tyr Pro Asp Thr Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
             20                  25                  30
Lys Thr Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
         35                  40                  45
Gln Arg Glu Ile Val Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Leu Lys Lys 
                 85                  90                  95
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
             100                105                110
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
     130                135                140
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
 145                150                155                160
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Asp Glu Asn Lys Gln 
                 165                170                175
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
             180                185                190
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
         195                200                205
Val Ala Ala Met Gln Gly Leu Asn Leu Gly Ser Pro Asn Asn Phe Leu 
     210                215                220
Ser Cys Tyr Arg Thr Thr His Phe Leu Ser Arg Val Ile Lys Cys Asp 
 225                230                235                240
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                 245                250                255
Ser Ser Leu Arg Gln Ala Gln Gln Asn Ile Asp Pro Lys Ala Thr Glu 
             260                265                270
Glu Glu Gly Glu Val Glu Glu Glu Ala Gly Leu Ala Cys Thr Pro Thr 
         275                280                285
Asp Val Arg Asp Val Asp Ile 
     290                295



<210> 1733
<211> 4244
<212> DNA
<213> Homo sapiens
<308> X59798
<400> 1733

ggcgcagta  cagcgagca  cagagtccg  acgctccgg  gaggggcag  agagcgcga  60
ggagcgcgg  gcagcagaa  cgagagccg  gcgcggacc  agccaggac  cacagccct  120
cccagctgc  caggaagag  cccagccat  gaacaccag  tcctgtgct  cgaagtgga  180
accatccgc  gcgcgtacc  cgatgccaa  ctcctcaac  accgggtgc  gcgggccat  240
ctgaaggcg  aggagacct  cgcgccctc  gtgtcctac  tcaaatgtg  gcagaagga  300
gtcctgccg  ccatgcgga  gatcgtcgc  acctggatg  tggaggtct  cgaggaaca  360
aagtgcgag  aggaggtct  cccgctggc  atgaactac  tggaccgct  cctgtcgct  420
gagcccgtg  aaaagagcc  cctgcagct  ctgggggcc  cttgcatgt  cgtggcctc  480
aagatgaag  agaccatcc  cctgacggc  gagaagctg  gcatctaca  cgacaactc  540
atccggccc  aggagctgc  gcaaatgga  ctgctcctg  tgaacaagc  caagtggaa  600
ctggccgca  tgaccccgc  cgatttcat  gaacacttc  tctccaaaa  gccagaggc  660
gaggagaac  aacagatca  ccgcaaaca  gcgcagacc  tcgttgccc  ctgtgccac  720
gatgtgaag  tcatttcca  tccgccctc  atggtggca  cggggagcg  ggtggccgc  780
gtgcaaggc  tgaacctga  gagccccaa  aacttcctg  cctactacc  cctcacacg  840
ttcctctcc  gagtgatca  gtgtgaccc  gactgcctc  gggcctgcc  ggagcagat  900
gaagccctg  tggagtcaa  cctgcgcca  gcccagcag  acatggacc  caaggccgc  960
gaggaggag  aagaggagg  ggaggaggt  gacctggct  gcacaccca  cgacgtgcg  1020
gacgtggac  tctgagggc  ccaggcagg  gggcgccac  gccacccgc  gcgagggcg  1080
agccggccc  aggtgctcc  ctgacagtc  ctcctctcc  gagcatttt  ataccagaa  1140
ggaaagctt  attctcctt  ttgttggtt  ttttttcct  tgctctttc  cccttccat  1200
tctgactta  gcaaaagaa  aagattacc  aaaaactgt  tttaaaaga  agagagaga  1260
aaaaaaaat  gtatttgca  aaccctgag  ggtggggga  gagggttgt  ctacagatg  1320
tagaggatt  tatacccca  taatcaact  gtttttata  taatgtact  gtttctctg  1380
tgtaagaat  ggcattaac  caaaggagg  gtctcggga  aggattagg  tccatcctt  1440
acgtgttta  aaaaaagca  aaaaacatt  taaaaacat  gaaaaattc  gcaaaccat  1500
tttaaagta  aagagggtt  taggtagaa  aacatattc  tgtgctttt  ctgataaag  1560
acagctgta  tggggttct  ggcatctct  tactttgct  gctcatatg  atgtagtca  1620
tttataagt  attgtatgt  attatattc  gtaggtaga  gtgtaacct  ttcacctta  1680
tcatggctg  agtcacctc  tggttacag  agcgtagcg  ggccgtgtg  atgtccttt  1740
cgcctgtga  caccacccc  acaaaccat  cagtgacaa  ccatccagt  gaggtttgt  1800
gggcaccag  cagcgtagc  gggtcggga  aggccacct  tcccactcc  acgatacgc  1860
actataaag  gaagacgaa  tagtgacat  atatattct  tttttatac  cttcctatt  1920
ttgtagtga  ctgtttatg  gatgctggt  ttctaccca  cggccctgc  gccagctca  1980
gtccaggtt  aacccacag  tacttggtt  gtgttcttc  tcatattct  aaaccattc  2040
atttccaag  actttcagt  caataggtg  aggaaatag  gctgttttt  ttgtgtgtg  2100
agggagggc  gttttctaa  ggaatggtt  gggaatatc  atgtacttg  ttgcaagca  2160
gactttgag  caagtgtgg  ccactgtgg  ggcagtgga  gtggggtgt  tgggaggct  2220
cgtgccagt  aagaagaaa  aggtttgca  tctcacatt  ccaggatga  aagttcctt  2280
ccttttctt  aaagaagtt  aagtttagg  atcctttgg  gccaactgg  gtttgaaag  2340
agggacctc  gaggtttac  tagagaaca  gtggttttt  agggttatc  tagatgttt  2400
acaccggaa  gtttttaaa  actaaaata  ataatttat  gttaaggct  aaaagtata  2460
ttattgcag  ggatgttca  aaggccagt  tgatttata  atgcaatct  cccttgatt  2520
aaacacaca  atacacaca  acacacaca  acacacaca  accttctgc  tttgatgtt  2580
cagatttaa  acagtttat  tttaaagat  gatcctttt  taggtgaga  aaaaacaat  2640
tggaagaaa  aaaccacac  aagacattg  ttcagcctg  ttggcgttt  ccagagtca  2700
ctgattgga  aggcatggg  gcaaggaaa  ttagggtac  caacctaag  tcggttccg  2760
tgaattctt  tcccctgcc  cttccttta  aaaacttag  gacaaaata  acaatttgc  2820
catcttggc  atgtaattc  tgtaatttt  atttaggaa  tgttgaagg  aggtggcaa  2880
agtgtggag  ctgacgtgt  agggaggac  ggcgggagg  ggtgtgagg  ggaggctcc  2940
gaggggaag  ggcggtgcc  acaccgggg  caggccgca  ctccatttt  ttattgcgc  3000
gctaccgtt  acttccagg  acggtttgg  aatattcac  tcgcttctg  gtatctctt  3060
cacattgtt  gctgctatt  gaggatcag  tttttgttt  acaatgtca  atactgcca  3120
gtactagtt  tagttttct  ttagaacat  gtattacag  tgccttttt  gtagttttt  3180
tttttttta  gtgatcaat  ttgacttaa  gtgattact  ctctattcc  aaaaggttg  3240
tgtttcaca  tacctcatg  ttcacttag  catggtgga  ccagcgggc  ggttctgcc  3300
gctttggcg  gcagacacg  gggcgcgat  ccacacagg  tggcggggg  cggccccga  3360
gccgcgtgc  tgagaaccg  gccggtgtc  ccagagacc  ggctgtgtc  ctcttctct  3420
ccctgcgcc  gtgatgctg  gcacttcat  tgatcgggg  cgtagcatc  tagtagttt  3480
tacagctgt  ttatwcttt  cgtgtagct  tggaagttg  ataattatt  ttattatta  3540
tataacaag  gtgtcttac  tgccaccac  gcgttgtac  tgtaggact  tcattcggg  3600
tgattggaa  agcttctgg  atttgttca  gttttgggt  tgtttaatc  gttatgtac  3660
agtgttctg  ttgttattg  tttgttaat  acaccataa  gctaattta  agagactcc  3720
aatctcaat  aagccagct  acagtgctg  gtgccccgg  cacctagca  gctgccgaa  3780
caaaagaat  tgcaccccg  tgcgggccc  cgtggttgg  gccctgccc  ggcagggtc  3840
tcctgtgct  ggaggccat  tcgggcaca  gcccacccc  ccccacccc  ccagaacac  3900
gctcacgct  acctcaacc  tcctggctg  ggcgtctgt  tgaaccacg  gggggcctt  3960
agggacgct  tgtctgtcg  gatggggca  gggcacaag  cctggatgt  gtgtgtrtc  4020
agaggccaa  ggctggtgg  aagtgcacg  ggcacagcg  agtctgtcc  gtgacgcgc  4080
agtctgagg  tctgggcgg  gggcggctg  gtctgtgca  ttctggttg  accgcggcg  4140
ttcccagca  caacatgta  ccggcatgt  tccagcaga  gacaaaaag  caaacatga  4200
agtctagaa  taaaactgg  aaaacccca  aaaaaaaaa  aaaa  4244



<210> 1734
<211> 295
<212> PRT
<213> Homo sapiens
<308> P24385
<400> 1734

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
  1               5                  10                  15
Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
             20                  25                  30
Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
         35                  40                  45
Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                 85                  90                  95
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
             100                105                110
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
     130                135                140
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
 145                150                155                160
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                 165                170                175
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
             180                185                190
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
         195                200                205
Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
     210                215                220
Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
 225                230                235                240
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                 245                250                255
Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
             260                265                270
Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
         275                280                285
Asp Val Arg Asp Val Asp Ile 
     290                295



<210> 1735
<211> 1957
<212> DNA
<213> Rattus norvegicus
<308> D14015
<400> 1735

tcgaggtcg  cggtatcga  aagtttgat  tcgatttcc  gcagcccgg  ggggatccc  60
ccagcgccg  gcgctccgg  cgccgcctc  cgcctcctg  ttcccgcct  ccgtcggcc  120
cctgtccgc  cgagcgcgc  tgtctgcgg  ggacacagc  tcgggtctg  gttccaagt  180
ctgagccat  ccaagggag  ggaaggaga  agactcgaa  gaccacacc  aatgaaaga  240
gaaggtggt  ccgacctct  agtccgatc  agaaaaagg  agccaaatg  gcccgtttt  300
ttgcaagat  cggatgaag  aattgccaa  attgacaag  ctgtgaaaa  ccaggatag  360
agtcagcct  gggatgatg  ttcagcgtg  gtggacccc  gctctttca  ccccacccc  420
aacaaagaa  aggacaatg  gcttgagta  cccaagact  catttcagc  tcggaaaat  480
agaccgccc  gagcctccc  acttcccgt  ttgaattgg  ccaatagag  agaggtctg  540
aggatcatg  taaacaaag  gaagactta  ctgagagat  agcactttc  gcagcgcca  600
cctctcctg  aggcgagga  gagagcagt  cttctggac  ggctgatgg  ggtgtgtga  660
gtctataag  tccacagag  gacattcta  ttggcacag  acttctttg  tcgttacat  720
gcatcacaa  agaatatca  aaaaacact  ttacagctt  ttgggattt  agccttatt  780
attgcttct  aacttgagg  aatctaccc  ccaaagttg  accagtttg  ttatgttac  840
gatggtgct  gctccgggg  tgaaattct  accatggaa  tgatgatga  gaaggccct  900
aagtggcgt  taagccccc  gaccattgt  tcctggctg  atgtttatg  ccaagtggc  960
tacgtcaac  acacgggag  agtgctgat  cctcagtac  cacagcagg  cttcgtgca  1020
atcgcagag  ttttagacc  gtgcgtcct  gatgttggc  gcttagaat  tccttatgg  1080
gtcctcgct  cttctgctt  gtatcattt  tcctcgttg  agttgatgc  gaaggtctc  1140
ggttatcag  ggtgtgata  agagaagtg  gtcaagtgg  tggttccat  cgccatggt  1200
atccgggag  tgggaagtt  caagctcaa  cacttccgg  gagttccca  ggaagactc  1260
cacaacatc  agacccaca  caacagctt  gacttgctg  acaaagccc  agcaaagaa  1320
gccatattg  cagaacaaa  taggatttc  cctcctccg  gtggggtcc  gacaccccc  1380
cacagcagt  agaagcaga  cagtgagca  gagacagaa  gaccagacc  gccatcgcc  1440
ccaaagaca  tggtgtgga  gcacctgcc  ggagctcct  gtgctgcct  ggaggtcag  1500
agcccctgc  gatgctatg  tctgtggag  ggtgtctct  ccagagcag  aggggtcta  1560
aagatgcct  ggacggaag  gctttgatt  aatgctagg  gttttaact  tagggtcga  1620
tacaccagc  acctccaga  caccactga  tgctccaga  gctgctaag  agggtgcta  1680
ttggaccca  tggactctt  acacagacg  caaaagctt  aagttaagg  ggccatggt  1740
cttgctggc  tctgctggg  gtcgcaggg  tgctgttga  agggtacgg  gagtggtcg  1800
gagcaagca  gggatgcag  gccacagcc  ggcctgagc  gcccttctc  actgtcagt  1860
gacagcata  cctgccttc  tgaacactc  tgttttgga  gtgctgcta  gtctatcaa  1920
tttaataaa  ataattcta  ctctgagaa  caaccaa  1957



<210> 1736
<211> 396
<212> PRT
<213> Rattus norvegicus
<308> BAA03116
<400> 1736

Met Lys Glu Glu Gly Gly Ser Asp Leu Ser Val Arg Ser Arg Lys Arg 
  1               5                  10                  15
Lys Pro Asn Val Pro Val Phe Leu Gln Asp Pro Asp Glu Glu Ile Ala 
             20                  25                  30
Lys Ile Asp Lys Thr Val Lys Ser Gln Asp Ser Ser Gln Pro Trp Asp 
         35                  40                  45
Asp Asp Ser Ala Cys Val Asp Pro Cys Ser Phe Ile Pro Thr Pro Asn 
     50                  55                  60
Lys Glu Glu Asp Asn Glu Leu Glu Tyr Pro Lys Thr Ala Phe Gln Pro 
 65                  70                  75                  80
Arg Lys Ile Arg Pro Pro Arg Ala Ser Pro Leu Pro Val Leu Asn Trp 
                 85                  90                  95
Ala Asn Arg Glu Glu Val Trp Arg Ile Met Leu Asn Lys Glu Lys Thr 
             100                105                110
Tyr Leu Arg Asp Glu His Phe Leu Gln Arg His Pro Leu Leu Gln Ala 
         115                120                125
Arg Met Arg Ala Val Leu Leu Asp Trp Leu Met Glu Val Cys Glu Val 
     130                135                140
Tyr Lys Leu His Arg Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp 
 145                150                155                160
Arg Tyr Met Ala Ser Gln Gln Asn Ile Ile Lys Thr Leu Leu Gln Leu 
                 165                170                175
Ile Gly Ile Ser Ala Leu Phe Ile Ala Ser Lys Leu Glu Glu Ile Tyr 
             180                185                190
Pro Pro Lys Leu His Gln Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser 
         195                200                205
Gly Asp Glu Ile Leu Thr Met Glu Leu Met Met Met Lys Ala Leu Lys 
     210                215                220
Trp Arg Leu Ser Pro Leu Thr Ile Val Ser Trp Leu Asn Val Tyr Val 
 225                230                235                240
Gln Val Ala Tyr Val Asn Asp Thr Gly Glu Val Leu Met Pro Gln Tyr 
                 245                250                255
Pro Gln Gln Val Phe Val Gln Ile Ala Glu Leu Leu Asp Leu Cys Val 
             260                265                270
Leu Asp Val Gly Cys Leu Glu Phe Pro Tyr Gly Val Leu Ala Ala Ser 
         275                280                285
Ala Leu Tyr His Phe Ser Ser Leu Glu Leu Met Gln Lys Val Ser Gly 
     290                295                300
Tyr Gln Trp Cys Asp Ile Glu Lys Cys Val Lys Trp Met Val Pro Phe 
 305                310                315                320
Ala Met Val Ile Arg Glu Met Gly Ser Ser Lys Leu Lys His Phe Arg 
                 325                330                335
Gly Val Pro Met Glu Asp Ser His Asn Ile Gln Thr His Thr Asn Ser 
             340                345                350
Leu Asp Leu Leu Asp Lys Ala Gln Ala Lys Lys Ala Ile Leu Ser Glu 
         355                360                365
Gln Asn Arg Ile Ser Pro Pro Pro Ser Gly Val Leu Thr Pro Pro His 
     370                375                380
Ser Ser Lys Lys Gln Ser Ser Glu Gln Glu Thr Glu 
 385                390                395



<210> 1738
<211> 410
<212> PRT
<213> Homo sapiens
<308> P24864
<400> 1738

Met Pro Arg Glu Arg Arg Glu Arg Asp Ala Lys Glu Arg Asp Thr Met 
  1               5                  10                  15
Lys Glu Asp Gly Gly Ala Glu Phe Ser Ala Arg Ser Arg Lys Arg Lys 
             20                  25                  30
Ala Asn Val Thr Val Phe Leu Gln Asp Pro Asp Glu Glu Met Ala Lys 
         35                  40                  45
Ile Asp Arg Thr Ala Arg Asp Gln Cys Gly Ser Gln Pro Trp Asp Asn 
     50                  55                  60
Asn Ala Val Cys Ala Asp Pro Cys Ser Leu Ile Pro Thr Pro Asp Lys 
 65                  70                  75                  80
Glu Asp Asp Asp Arg Val Tyr Pro Asn Ser Thr Cys Lys Pro Arg Ile 
                 85                  90                  95
Ile Ala Pro Ser Arg Gly Ser Pro Leu Pro Val Leu Ser Trp Ala Asn 
             100                105                110
Arg Glu Glu Val Trp Lys Ile Met Leu Asn Lys Glu Lys Thr Tyr Leu 
         115                120                125
Arg Asp Gln His Phe Leu Glu Gln His Pro Leu Leu Gln Pro Lys Met 
     130                135                140
Arg Ala Ile Leu Leu Asp Trp Leu Met Glu Val Cys Glu Val Tyr Lys 
 145                150                155                160
Leu His Arg Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg Tyr 
                 165                170                175
Met Ala Thr Gln Glu Asn Val Val Lys Thr Leu Leu Gln Leu Ile Gly 
             180                185                190
Ile Ser Ser Leu Phe Ile Ala Ala Lys Leu Glu Glu Ile Tyr Pro Pro 
         195                200                205
Lys Leu His Gln Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser Gly Asp 
     210                215                220
Glu Ile Leu Thr Met Glu Leu Met Ile Met Lys Ala Leu Lys Trp Arg 
 225                230                235                240
Leu Ser Pro Leu Thr Ile Val Ser Trp Leu Asn Val Tyr Met Gln Val 
                 245                250                255
Ala Tyr Leu Asn Asp Leu His Glu Val Leu Leu Pro Gln Tyr Pro Gln 
             260                265                270
Gln Ile Phe Ile Gln Ile Ala Glu Leu Leu Asp Leu Cys Val Leu Asp 
         275                280                285
Val Asp Cys Leu Glu Phe Pro Tyr Gly Ile Leu Ala Ala Ser Ala Leu 
     290                295                300
Tyr His Phe Ser Ser Ser Glu Leu Met Gln Lys Val Ser Gly Tyr Gln 
 305                310                315                320
Trp Cys Asp Ile Glu Asn Cys Val Lys Trp Met Val Pro Phe Ala Met 
                 325                330                335
Val Ile Arg Glu Thr Gly Ser Ser Lys Leu Lys His Phe Arg Gly Val 
             340                345                350
Ala Asp Glu Asp Ala His Asn Ile Gln Thr His Arg Asp Ser Leu Asp 
         355                360                365
Leu Leu Asp Lys Ala Arg Ala Lys Lys Ala Met Leu Ser Glu Gln Asn 
     370                375                380
Arg Ala Ser Pro Leu Pro Ser Gly Leu Leu Thr Pro Pro Gln Ser Gly 
 385                390                395                400
Lys Lys Gln Ser Ser Gly Pro Glu Met Ala 
                 405                410



<210> 1739
<211> 1957
<212> DNA
<213> Rattus norvegicus
<308> D14015
<400> 1739

tcgaggtcg  cggtatcga  aagtttgat  tcgatttcc  gcagcccgg  ggggatccc  60
ccagcgccg  gcgctccgg  cgccgcctc  cgcctcctg  ttcccgcct  ccgtcggcc  120
cctgtccgc  cgagcgcgc  tgtctgcgg  ggacacagc  tcgggtctg  gttccaagt  180
ctgagccat  ccaagggag  ggaaggaga  agactcgaa  gaccacacc  aatgaaaga  240
gaaggtggt  ccgacctct  agtccgatc  agaaaaagg  agccaaatg  gcccgtttt  300
ttgcaagat  cggatgaag  aattgccaa  attgacaag  ctgtgaaaa  ccaggatag  360
agtcagcct  gggatgatg  ttcagcgtg  gtggacccc  gctctttca  ccccacccc  420
aacaaagaa  aggacaatg  gcttgagta  cccaagact  catttcagc  tcggaaaat  480
agaccgccc  gagcctccc  acttcccgt  ttgaattgg  ccaatagag  agaggtctg  540
aggatcatg  taaacaaag  gaagactta  ctgagagat  agcactttc  gcagcgcca  600
cctctcctg  aggcgagga  gagagcagt  cttctggac  ggctgatgg  ggtgtgtga  660
gtctataag  tccacagag  gacattcta  ttggcacag  acttctttg  tcgttacat  720
gcatcacaa  agaatatca  aaaaacact  ttacagctt  ttgggattt  agccttatt  780
attgcttct  aacttgagg  aatctaccc  ccaaagttg  accagtttg  ttatgttac  840
gatggtgct  gctccgggg  tgaaattct  accatggaa  tgatgatga  gaaggccct  900
aagtggcgt  taagccccc  gaccattgt  tcctggctg  atgtttatg  ccaagtggc  960
tacgtcaac  acacgggag  agtgctgat  cctcagtac  cacagcagg  cttcgtgca  1020
atcgcagag  ttttagacc  gtgcgtcct  gatgttggc  gcttagaat  tccttatgg  1080
gtcctcgct  cttctgctt  gtatcattt  tcctcgttg  agttgatgc  gaaggtctc  1140
ggttatcag  ggtgtgata  agagaagtg  gtcaagtgg  tggttccat  cgccatggt  1200
atccgggag  tgggaagtt  caagctcaa  cacttccgg  gagttccca  ggaagactc  1260
cacaacatc  agacccaca  caacagctt  gacttgctg  acaaagccc  agcaaagaa  1320
gccatattg  cagaacaaa  taggatttc  cctcctccg  gtggggtcc  gacaccccc  1380
cacagcagt  agaagcaga  cagtgagca  gagacagaa  gaccagacc  gccatcgcc  1440
ccaaagaca  tggtgtgga  gcacctgcc  ggagctcct  gtgctgcct  ggaggtcag  1500
agcccctgc  gatgctatg  tctgtggag  ggtgtctct  ccagagcag  aggggtcta  1560
aagatgcct  ggacggaag  gctttgatt  aatgctagg  gttttaact  tagggtcga  1620
tacaccagc  acctccaga  caccactga  tgctccaga  gctgctaag  agggtgcta  1680
ttggaccca  tggactctt  acacagacg  caaaagctt  aagttaagg  ggccatggt  1740
cttgctggc  tctgctggg  gtcgcaggg  tgctgttga  agggtacgg  gagtggtcg  1800
gagcaagca  gggatgcag  gccacagcc  ggcctgagc  gcccttctc  actgtcagt  1860
gacagcata  cctgccttc  tgaacactc  tgttttgga  gtgctgcta  gtctatcaa  1920
tttaataaa  ataattcta  ctctgagaa  caaccaa  1957



<210> 1740
<211> 396
<212> PRT
<213> Rattus norvegicus
<308> BAA03116
<400> 1740

Met Lys Glu Glu Gly Gly Ser Asp Leu Ser Val Arg Ser Arg Lys Arg 
  1               5                  10                  15
Lys Pro Asn Val Pro Val Phe Leu Gln Asp Pro Asp Glu Glu Ile Ala 
             20                  25                  30
Lys Ile Asp Lys Thr Val Lys Ser Gln Asp Ser Ser Gln Pro Trp Asp 
         35                  40                  45
Asp Asp Ser Ala Cys Val Asp Pro Cys Ser Phe Ile Pro Thr Pro Asn 
     50                  55                  60
Lys Glu Glu Asp Asn Glu Leu Glu Tyr Pro Lys Thr Ala Phe Gln Pro 
 65                  70                  75                  80
Arg Lys Ile Arg Pro Pro Arg Ala Ser Pro Leu Pro Val Leu Asn Trp 
                 85                  90                  95
Ala Asn Arg Glu Glu Val Trp Arg Ile Met Leu Asn Lys Glu Lys Thr 
             100                105                110
Tyr Leu Arg Asp Glu His Phe Leu Gln Arg His Pro Leu Leu Gln Ala 
         115                120                125
Arg Met Arg Ala Val Leu Leu Asp Trp Leu Met Glu Val Cys Glu Val 
     130                135                140
Tyr Lys Leu His Arg Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp 
 145                150                155                160
Arg Tyr Met Ala Ser Gln Gln Asn Ile Ile Lys Thr Leu Leu Gln Leu 
                 165                170                175
Ile Gly Ile Ser Ala Leu Phe Ile Ala Ser Lys Leu Glu Glu Ile Tyr 
             180                185                190
Pro Pro Lys Leu His Gln Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser 
         195                200                205
Gly Asp Glu Ile Leu Thr Met Glu Leu Met Met Met Lys Ala Leu Lys 
     210                215                220
Trp Arg Leu Ser Pro Leu Thr Ile Val Ser Trp Leu Asn Val Tyr Val 
 225                230                235                240
Gln Val Ala Tyr Val Asn Asp Thr Gly Glu Val Leu Met Pro Gln Tyr 
                 245                250                255
Pro Gln Gln Val Phe Val Gln Ile Ala Glu Leu Leu Asp Leu Cys Val 
             260                265                270
Leu Asp Val Gly Cys Leu Glu Phe Pro Tyr Gly Val Leu Ala Ala Ser 
         275                280                285
Ala Leu Tyr His Phe Ser Ser Leu Glu Leu Met Gln Lys Val Ser Gly 
     290                295                300
Tyr Gln Trp Cys Asp Ile Glu Lys Cys Val Lys Trp Met Val Pro Phe 
 305                310                315                320
Ala Met Val Ile Arg Glu Met Gly Ser Ser Lys Leu Lys His Phe Arg 
                 325                330                335
Gly Val Pro Met Glu Asp Ser His Asn Ile Gln Thr His Thr Asn Ser 
             340                345                350
Leu Asp Leu Leu Asp Lys Ala Gln Ala Lys Lys Ala Ile Leu Ser Glu 
         355                360                365
Gln Asn Arg Ile Ser Pro Pro Pro Ser Gly Val Leu Thr Pro Pro His 
     370                375                380
Ser Ser Lys Lys Gln Ser Ser Glu Gln Glu Thr Glu 
 385                390                395



<210> 1742
<211> 410
<212> PRT
<213> Homo sapiens
<308> P24864
<400> 1742

Met Pro Arg Glu Arg Arg Glu Arg Asp Ala Lys Glu Arg Asp Thr Met 
  1               5                  10                  15
Lys Glu Asp Gly Gly Ala Glu Phe Ser Ala Arg Ser Arg Lys Arg Lys 
             20                  25                  30
Ala Asn Val Thr Val Phe Leu Gln Asp Pro Asp Glu Glu Met Ala Lys 
         35                  40                  45
Ile Asp Arg Thr Ala Arg Asp Gln Cys Gly Ser Gln Pro Trp Asp Asn 
     50                  55                  60
Asn Ala Val Cys Ala Asp Pro Cys Ser Leu Ile Pro Thr Pro Asp Lys 
 65                  70                  75                  80
Glu Asp Asp Asp Arg Val Tyr Pro Asn Ser Thr Cys Lys Pro Arg Ile 
                 85                  90                  95
Ile Ala Pro Ser Arg Gly Ser Pro Leu Pro Val Leu Ser Trp Ala Asn 
             100                105                110
Arg Glu Glu Val Trp Lys Ile Met Leu Asn Lys Glu Lys Thr Tyr Leu 
         115                120                125
Arg Asp Gln His Phe Leu Glu Gln His Pro Leu Leu Gln Pro Lys Met 
     130                135                140
Arg Ala Ile Leu Leu Asp Trp Leu Met Glu Val Cys Glu Val Tyr Lys 
 145                150                155                160
Leu His Arg Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg Tyr 
                 165                170                175
Met Ala Thr Gln Glu Asn Val Val Lys Thr Leu Leu Gln Leu Ile Gly 
             180                185                190
Ile Ser Ser Leu Phe Ile Ala Ala Lys Leu Glu Glu Ile Tyr Pro Pro 
         195                200                205
Lys Leu His Gln Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser Gly Asp 
     210                215                220
Glu Ile Leu Thr Met Glu Leu Met Ile Met Lys Ala Leu Lys Trp Arg 
 225                230                235                240
Leu Ser Pro Leu Thr Ile Val Ser Trp Leu Asn Val Tyr Met Gln Val 
                 245                250                255
Ala Tyr Leu Asn Asp Leu His Glu Val Leu Leu Pro Gln Tyr Pro Gln 
             260                265                270
Gln Ile Phe Ile Gln Ile Ala Glu Leu Leu Asp Leu Cys Val Leu Asp 
         275                280                285
Val Asp Cys Leu Glu Phe Pro Tyr Gly Ile Leu Ala Ala Ser Ala Leu 
     290                295                300
Tyr His Phe Ser Ser Ser Glu Leu Met Gln Lys Val Ser Gly Tyr Gln 
 305                310                315                320
Trp Cys Asp Ile Glu Asn Cys Val Lys Trp Met Val Pro Phe Ala Met 
                 325                330                335
Val Ile Arg Glu Thr Gly Ser Ser Lys Leu Lys His Phe Arg Gly Val 
             340                345                350
Ala Asp Glu Asp Ala His Asn Ile Gln Thr His Arg Asp Ser Leu Asp 
         355                360                365
Leu Leu Asp Lys Ala Arg Ala Lys Lys Ala Met Leu Ser Glu Gln Asn 
     370                375                380
Arg Ala Ser Pro Leu Pro Ser Gly Leu Leu Thr Pro Pro Gln Ser Gly 
 385                390                395                400
Lys Lys Gln Ser Ser Gly Pro Glu Met Ala 
                 405                410



<210> 1743
<211> 467
<212> DNA
<213> Rattus norvegicus
<308> D14418
<400> 1743

tgccaagtg  cgagtgcgg  tggccatca  tgaatacat  cctctgctg  ctggacagc  60
cggtgtgga  ttttttgat  agaaactta  ctctttgtg  atggcctgg  tagtggatc  120
tgtctatgc  atccgtgag  ctgccacca  caaccttaa  aagctagtg  agaagttcg  180
gaaggagtg  gcccatgcc  ctatcatcc  caaggtctt  gccatgtct  gagacccta  240
ctacctgca  cgaatgact  cactcttct  catcagtgt  ttgtctgag  tctgtgggc  300
ggatattac  acgaagcac  tgctgccca  agttcttcg  atggctggg  acccagtcg  360
caatgtccg  ttcaatgtg  ccaagtcac  acagaagat  ggacccatt  ttgataaca  420
caccctgca  agtgaagtc  agcctatcc  agagaagct  acccagg  467



<210> 1744
<211> 155
<212> PRT
<213> Rattus norvegicus
<308> BAA21903
<400> 1744

Ala Lys Trp Arg Val Arg Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu 
  1               5                  10                  15
Ala Gly Gln Leu Gly Val Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu 
             20                  25                  30
Cys Met Ala Trp Leu Val Asp His Val Tyr Ala Ile Arg Glu Ala Ala 
         35                  40                  45
Thr Ser Asn Leu Lys Lys Leu Val Glu Lys Phe Gly Lys Glu Trp Ala 
     50                  55                  60
His Ala Thr Ile Ile Pro Lys Val Leu Ala Met Ser Gly Asp Pro Asn 
 65                  70                  75                  80
Tyr Leu His Arg Met Thr Thr Leu Phe Cys Ile Ser Val Leu Ser Glu 
                 85                  90                  95
Val Cys Gly Gln Asp Ile Thr Thr Lys His Met Leu Pro Thr Val Leu 
             100                105                110
Arg Met Ala Gly Asp Pro Val Ala Asn Val Arg Phe Asn Val Ala Lys 
         115                120                125
Ser Leu Gln Lys Ile Gly Pro Ile Leu Asp Asn Ser Thr Leu Gln Ser 
     130                135                140
Glu Val Lys Pro Ile Leu Glu Lys Leu Thr Gln 
 145                150                155



<210> 1745
<211> 1767
<212> DNA
<213> Homo sapiens
<308> M31786
<400> 1745

atggcggcg  ccgacggcg  cgactcgct  taccccatc  cggtgctca  agacgaact  60
cgcaatgag  acgttcagc  tcgcctcaa  agcatcaag  agctgtcca  catcgcctt  120
gcccttggg  ttgaaagga  ccgaagtga  cttctgcct  tccttacag  taccatcta  180
gatgaagat  aggtcctcc  ggccctggc  gaacagctg  gaaccttca  taccctggt  240
ggaggccca  agtacgtgc  ctgcctgct  ccaccgctg  agtcgctgg  cacagtgga  300
gagacagtg  tgcgggaca  ggcagtgga  tccttacgg  ccatctcac  cgagcactc  360
ccctctgac  tggaggcgc  ctttgtcgc  ctagtgaag  ggctggcgg  cggcgactg  420
ttcacctcc  gcacctcgg  ctgcggcct  ttctccgtc  gctaccccc  agtgtccag  480
gctgtgaag  cggaacttc  acagtactt  cggaacctg  gctcagatg  cacccccat  540
gtgcggcgg  ccgcagcct  caagctggg  gagtttgcc  aggtgctgg  gctggacaa  600
gtcaagagt  agatcatcc  catgttctc  aacctggcc  ctgacgagc  ggactcggt  660
cggctgctg  cggtggagg  gtgcgtgaa  atagcccag  ttctgcccc  ggaggatct  720
gaggccctg  tgatgccca  tctgcgcca  gccgctgaa  acaagtcct  gcgcgtccg  780
tacatggtg  ctgacaagt  cacagagct  cagaaagca  tggggcctg  gatcaccaa  840
acagacctg  tccctgcct  ccagaacct  atgaaagac  gtgaggccg  ggtgagggc  900
gcagcctcc  acaaggtca  agagttctg  gaaaacctc  cagctgact  tcgggagaa  960
gtgatcatg  cccagatct  gccctgcat  aaggagctg  tgtccgatg  caaccaaca  1020
gtcaagtct  ccctggcct  agtcatcat  ggtctctct  ccatcttgg  gaaagacaa  1080
accatcgag  acctcttgc  cctcttcct  gctcagctg  aggatgagt  ccctgaggt  1140
cggctgaac  tcatctcta  cctggactg  gtgaacgag  tgattggca  ccggcagct  1200
tcccagtcc  tgctccctg  cattgtgga  ctggctgag  acgccaagt  gcgggtgcg  1260
ctggccatc  ttgagtaca  gcccctcct  gctggacag  tgggagtgg  gttctttga  1320
gagaaactt  actccttgt  catggcctg  cttgtggat  atgtatatg  catccgcga  1380
gcagccacc  gcaacctga  gaagctagt  gaaaagttt  ggaaggagt  ggcccatgc  1440
acaatcatc  ccaaggtct  ggccatgtc  ggagacccc  actacctgc  ccgcatgac  1500
acgctcttc  gcatcaatg  gctgtctga  gtctgtggg  aggacatca  caccaagca  1560
atgctaccc  cggttctgc  catggctgg  gacccggtt  ccaatgtcc  cttcaatgt  1620
gccaagtct  tgcagaaga  agggcccat  ctggacaac  gcaccttgc  gagtgaagt  1680
aagcccatc  tagagaagc  gacccagga  caggatgtg  acgtcaaat  ctttgccca  1740
gaggctctg  ctgttctgt  tctcgcc  1767



<210> 1746
<211> 588
<212> PRT
<213> Homo sapiens
<308> AAA35531
<400> 1746

Ala Ala Ala Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu Ile 
  1               5                  10                  15
Asp Glu Leu Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile Lys 
             20                  25                  30
Lys Leu Ser Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg Ser 
         35                  40                  45
Glu Leu Leu Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu Val 
     50                  55                  60
Leu Leu Ala Leu Ala Glu Gln Leu Gly Thr Phe Thr Thr Leu Val Gly 
 65                  70                  75                  80
Gly Pro Glu Tyr Val His Cys Leu Leu Pro Pro Leu Glu Ser Leu Ala 
                 85                  90                  95
Thr Val Glu Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu Arg 
             100                105                110
Ala Ile Ser His Glu His Ser Pro Ser Asp Leu Glu Ala His Phe Val 
         115                120                125
Pro Leu Val Lys Arg Leu Ala Gly Gly Asp Trp Phe Thr Ser Arg Thr 
     130                135                140
Ser Ala Cys Gly Leu Phe Ser Val Cys Tyr Pro Arg Val Ser Ser Ala 
 145                150                155                160
Val Lys Ala Glu Leu Arg Gln Tyr Phe Arg Asn Leu Cys Ser Asp Asp 
                 165                170                175
Thr Pro Met Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe Ala 
             180                185                190
Lys Val Leu Glu Leu Asp Asn Val Lys Ser Glu Ile Ile Pro Met Phe 
         195                200                205
Ser Asn Leu Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala Val 
     210                215                220
Glu Ala Cys Val Asn Ile Ala Gln Leu Leu Pro Gln Glu Asp Leu Glu 
 225                230                235                240
Ala Leu Val Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser Trp 
                 245                250                255
Ala Val Arg Tyr Met Val Ala Asp Lys Phe Thr Glu Leu Gln Lys Ala 
             260                265                270
Val Gly Pro Glu Ile Thr Lys Thr Asp Leu Val Pro Ala Phe Gln Asn 
         275                280                285
Leu Met Lys Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ser His Lys 
     290                295                300
Val Lys Glu Phe Cys Glu Asn Leu Ser Ala Asp Cys Arg Glu Asn Val 
 305                310                315                320
Ile Met Ser Gln Ile Leu Pro Cys Ile Lys Glu Leu Val Ser Asp Ala 
                 325                330                335
Asn Gln His Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu Ser 
             340                345                350
Pro Ile Leu Gly Lys Asp Asn Thr Ile Glu His Leu Leu Pro Leu Phe 
         355                360                365
Leu Ala Gln Leu Lys Asp Glu Cys Pro Glu Val Arg Leu Asn Ile Ile 
     370                375                380
Ser Asn Leu Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu Ser 
 385                390                395                400
Gln Ser Leu Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys Trp 
                 405                410                415
Arg Val Arg Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly Gln 
             420                425                430
Leu Gly Val Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met Ala 
         435                440                445
Trp Leu Val Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Ser Asn 
     450                455                460
Leu Lys Lys Leu Val Glu Lys Phe Gly Lys Glu Trp Ala His Ala Thr 
 465                470                475                480
Ile Ile Pro Lys Val Leu Ala Met Ser Gly Asp Pro Asn Tyr Leu His 
                 485                490                495
Arg Met Thr Thr Leu Phe Cys Ile Asn Val Leu Ser Glu Val Cys Gly 
             500                505                510
Gln Asp Ile Thr Thr Lys His Met Leu Pro Thr Val Leu Arg Met Ala 
         515                520                525
Gly Asp Pro Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu Gln 
     530                535                540
Lys Ile Gly Pro Ile Leu Asp Asn Ser Thr Leu Gln Ser Glu Val Lys 
 545                550                555                560
Pro Ile Leu Glu Lys Leu Thr Gln Asp Gln Asp Val Asp Val Lys Tyr 
                 565                570                575
Phe Ala Gln Glu Ala Leu Thr Val Leu Ser Leu Ala 
             580                585



<210> 1747
<211> 579
<212> DNA
<213> Rattus norvegicus
<308> D14419
<400> 1747

catgagcca  aatttgact  cttgaaaag  ttagaaata  aagagaaga  caacaaaat  60
aggtggtta  cccagagaa  tgctgccca  tttttattg  ctaccaatg  taaaacaat  120
aaattatgg  aaatcagtg  aagagacaa  agaccagaa  gctataact  gaaagagga  180
gatgggagg  atagagacc  tactacagt  actacacta  gagtgccgg  gtttaggcc  240
atggatcta  tggtggagg  cagtccgcg  agaatattt  ccaacgccc  tacctacca  300
atcaactcc  tttctatca  tagtgatta  gaaacctac  tatcagcag  tgatttgcg  360
attaatctc  ggcatctgg  aattacaga  aggagtttt  gtattgtgg  cattaagcc  420
gccaatgtg  aggagctca  ggaggtgat  acagccgca  agttccatc  caacagctg  480
aacacgttt  tgtacagca  cagtaaagg  accattcgc  tatgtgaca  gagggcatc  540
gcactctgt  acaggcatt  taaactgtt  gaagaaccc  579



<210> 1748
<211> 447
<212> PRT
<213> Rattus norvegicus
<308> AAA41910
<400> 1748

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
  1               5                  10                  15
Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
             20                  25                  30
Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
         35                  40                  45
Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
     50                  55                  60
Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
 65                  70                  75                  80
Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                 85                  90                  95
Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
             100                105                110
Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
         115                120                125
Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
     130                135                140
Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
 145                150                155                160
Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                 165                170                175
Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
             180                185                190
Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
         195                200                205
Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
     210                215                220
Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
 225                230                235                240
Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                 245                250                255
Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
             260                265                270
Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
         275                280                285
Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
     290                295                300
Tyr Leu Ser Val Lys Val Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
 305                310                315                320
Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                 325                330                335
Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
             340                345                350
Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
         355                360                365
Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
     370                375                380
Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
 385                390                395                400
Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                 405                410                415
Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
             420                425                430
Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440                445



<210> 1749
<211> 2131
<212> DNA
<213> Homo sapiens
<308> NM_002717
<400> 1749

ccgccgcca  ccgccctct  taccccccc  tccccaggt  aggggggtg  gttcaggaa  60
cggagaccc  gaggaaccc  gcagggtca  catttgcag  gcaacatgg  aggagctgg  120
ggagggaat  atattcagt  gtgtttttc  caggtgaaa  gagcagtag  tgatgatgt  180
gcagaagca  atataattt  tacagtaga  tttaatcat  ctggagaat  actagcaac  240
ggagataaa  gtggtagag  tgtcatctt  caacaggag  aggagaaca  aatccagtc  300
catagcaga  gagaatata  tgtttacag  accttccag  gccatgaac  agagtttga  360
tacttgaaa  gtttagaaa  agaagaaaa  atcaataaa  ttaggtggt  accccagaa  420
aatgctgct  agtttttat  gtctaccaa  gataaaaca  taaaattat  gaaaatcag  480
gaaagggac  aaagaccag  agggtataa  ttgaaagag  aggatggaa  gtatagaga  540
cctactaca  ttactacac  acgagtgcc  gtctttagg  ctatggatc  aatggttga  600
gccagtcca  gaagaatat  tgccaatgc  catacatat  acatcaact  aatttctat  660
aatagtgat  atgaaacat  tttatctgc  gatgatttg  ggattaatc  ttggcatct  720
gaaattaca  acaggagtt  taacattgt  gatatcaag  ctgccaata  ggaagagct  780
acagaggtg  ttacagcag  agaatttca  ccaaacagc  gtaacacat  tgtatacag  840
agcagtaaa  gaactattc  gctatgtga  atgagggca  ctgccctct  tgatagaca  900
tctaaattg  ttgaagaac  tgaagatcc  agtaacagg  cattttttt  cgaaatcat  960
tcctctatt  cggatgtaa  attcagcca  agtggtcga  atatgatga  tagagacta  1020
ttgtcagtc  aaatttggg  cttaaatat  gaaaacagg  ctgtggaaa  ataccaggt  1080
catgaatac  tcagaagta  actctgttc  ctgtatgaa  atgactgca  atttgacaa  1140
tttgaatgt  gttggaatg  atctgacag  gttgtcatg  ctggatctt  caataattt  1200
ttcagaatg  ttgacagaa  cacaaagcg  gacataacc  tagaagcat  gcgggaaaa  1260
aataagcct  gcacagttc  gaagcctcg  aaagtctgt  caagtggca  gcgaaagaa  1320
gatgaaata  gtgttgaca  cctagactt  aataagaaa  tccttcaca  agcctggca  1380
cccaaggaa  atatcattg  cgtagctac  acaaacaat  tgtatatat  tcaagacaa  1440
gtgaattag  gttggcatt  ctagcagaa  aacccactt  ctgcttagt  gagatagtt  1500
aatctagca  tcgttccta  aaaagagag  ggtccattg  ggcgcccct  tccagtgtt  1560
gacagtgtg  cattcgaca  cacattgtt  tagctacat  gagaaagct  tgtggattc  1620
tcactgtgg  gttctccat  tctgctagc  atttaggta  gggtagggc  cttttaatt  1680
aaatgactt  ttgcaccat  ttgcctaat  gactagatt  gactgtatc  acattgatt  1740
actccactt  ttatgcctt  cattgtgat  acgtcaaac  cagtgaaag  cttcagtca  1800
gctatggga  ttaattgtg  atcctcatt  ctgtatcat  tgtggggta  accccttcc  1860
ccttttttt  aattaaata  agctcattc  tactgtggc  tgtagcatt  ctcctcttc  1920
ggcctcctg  actgctccc  ttcatctct  acccttgcc  cctccaccc  gtcttggtg  1980
tggtatatt  aaaaaagaa  gaatgaaag  acacaaaat  agtcagttt  gggtcagtg  2040
tataaaggg  gtatatgtt  caaacaaat  ttttagtaa  agttggctg  aatcactcc  2100
cgccgtgtc  ggcactgaa  ataaggaaa  g  2131



<210> 1750
<211> 447
<212> PRT
<213> Homo sapiens
<308> Q00007
<400> 1750

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
  1               5                  10                  15
Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
             20                  25                  30
Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
         35                  40                  45
Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
     50                  55                  60
Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
 65                  70                  75                  80
Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                 85                  90                  95
Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
             100                105                110
Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
         115                120                125
Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
     130                135                140
Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
 145                150                155                160
Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                 165                170                175
Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
             180                185                190
Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
         195                200                205
Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
     210                215                220
Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
 225                230                235                240
Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                 245                250                255
Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
             260                265                270
Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
         275                280                285
Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
     290                295                300
Tyr Leu Ser Val Lys Ile Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
 305                310                315                320
Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                 325                330                335
Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
             340                345                350
Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
         355                360                365
Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
     370                375                380
Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
 385                390                395                400
Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                 405                410                415
Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
             420                425                430
Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440                445



<210> 1751
<211> 512
<212> DNA
<213> Rattus norvegicus
<308> D14421
<400> 1751

ccgcaaaat  aacaacagt  tcctgcgcg  ccacagcta  gcaaccgaa  ctgacatta  60
ctctacggt  gaattcaac  acactggag  gttactagc  acgggggac  aggggggta  120
ggttgtaat  tttcagcga  aacaggaga  taaaaatca  gttcatcgt  ggggtgaat  180
caatgttta  agcacattc  agagccatg  acccgagtt  gattacctg  aaagtttag  240
aatagaaga  aaaatcaat  aaataagat  gctccctca  caaaatgca  cttactttc  300
tctgtctac  aacgataaa  ctgtgaagc  atggaaagt  agtgagcgt  ataagaggc  360
agaaggcta  aacctgaaa  atgaggagg  ccggctccg  gatcctgcc  ccatcacaa  420
cctgcgggt  cctgtcctg  gacccatgg  cttgatggt  gaggccacc  cacgaagag  480
gtttgccaa  gcgcacaca  accacatca  ct  512



<210> 1752
<211> 443
<212> PRT
<213> Rattus norvegicus
<308> BAA03313
<400> 1752

Met Glu Glu Asp Ile Asp Thr Arg Lys Ile Asn Asn Ser Phe Leu Arg 
  1               5                  10                  15
Asp His Ser Tyr Ala Thr Glu Ala Asp Ile Ile Ser Thr Val Glu Phe 
             20                  25                  30
Asn His Thr Gly Glu Leu Leu Ala Thr Gly Asp Lys Gly Gly Arg Val 
         35                  40                  45
Val Ile Phe Gln Arg Glu Gln Glu Ser Lys Asn Gln Val His Arg Arg 
     50                  55                  60
Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His Glu Pro Glu Phe 
 65                  70                  75                  80
Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile Asn Lys Ile Arg 
                 85                  90                  95
Trp Leu Pro Gln Gln Asn Ala Ala Tyr Phe Leu Leu Ser Thr Asn Asp 
             100                105                110
Lys Thr Val Lys Leu Trp Lys Val Ser Glu Arg Asp Lys Arg Pro Glu 
         115                120                125
Gly Tyr Asn Leu Lys Asp Glu Glu Gly Arg Leu Arg Asp Pro Ala Thr 
     130                135                140
Ile Thr Thr Leu Arg Val Pro Val Leu Arg Pro Met Asp Leu Met Val 
 145                150                155                160
Glu Ala Thr Pro Arg Arg Val Phe Ala Asn Ala His Thr Tyr His Ile 
                 165                170                175
Asn Ser Ile Ser Val Asn Ser Asp Tyr Glu Thr Tyr Met Ser Ala Asp 
             180                185                190
Asp Leu Arg Ile Asn Leu Trp Asn Phe Glu Ile Thr Asn Gln Ser Phe 
         195                200                205
Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu Leu Thr Glu Val 
     210                215                220
Ile Thr Ala Ala Glu Phe His Pro His His Cys Asn Thr Phe Val Tyr 
 225                230                235                240
Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met Arg Ala Ser Ala 
                 245                250                255
Leu Cys Asp Arg His Thr Lys Phe Phe Glu Glu Pro Glu Asp Pro Ser 
             260                265                270
Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile Ser Asp Val Lys 
         275                280                285
Phe Ser His Ser Gly Arg Tyr Ile Met Thr Arg Asp Tyr Leu Thr Ala 
     290                295                300
Lys Val Trp Asp Leu Asn Met Glu Asn Arg Pro Val Glu Thr Tyr Gln 
 305                310                315                320
Val His Asp Tyr Leu Arg Ser Lys Leu Cys Ser Leu Tyr Glu Asn Asp 
                 325                330                335
Cys Ile Phe Asp Lys Phe Glu Cys Val Trp Asn Gly Ser Asp Ser Val 
             340                345                350
Ile Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met Phe Asp Arg Asn 
         355                360                365
Thr Lys Arg Asp Val Thr Leu Glu Ala Ser Arg Glu Asn Ser Lys Pro 
     370                375                380
Arg Ala Ile Leu Lys Pro Arg Lys Val Cys Val Gly Gly Lys Arg Arg 
 385                390                395                400
Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Ser Lys Lys Ile Leu 
                 405                410                415
His Thr Ala Trp His Pro Ser Glu Asn Ile Ile Ala Val Ala Ala Thr 
             420                425                430
Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440



<210> 1753
<211> 3441
<212> DNA
<213> Homo sapiens
<308> NM_004576
<400> 1753

ggccaggca  gcctgaatc  tgtccctgc  atctcgcca  tgcagctcg  gtccagaaa  60
gcaccattt  gtcgcggct  cccgctctc  cagggggag  agggatctt  tttgcattt  120
ggagcggct  ccaaggagg  gaacctgtt  ggcatctcc  cagacccgc  tgtgagcgc  180
tccggggcg  gcgggcggg  ccagacccc  cggggcacg  cgtatcttg  cacccggag  240
cagcggagg  aggcgcagc  tcctcgctg  gaactggag  tggagtgag  gcaccgcgc  300
ggaggagcc  ccgcagcct  gcagaaccc  agtggagga  gtgacagct  cattgccgg  360
tttttattt  ttttctctc  gcctccccg  ctcctcctc  ggctcggac  atggtgcag  420
cccactggc  cccctgccc  cctctcctg  gagactggc  gcggggagg  atcatggat  480
cttgtctgc  ggcttctgg  tcccacgca  gtaagcctg  tgtcaatgg  ggaggacat  540
gatacccgc  aaatcaaca  cagtttcct  cgcgaccac  gctatgcga  cgaagctga  600
attatctct  cggtagaat  caaccacac  ggagaatta  tagcgacag  ggacaaggg  660
ggtcgggtt  taatatttc  acgagagca  gagagtaaa  atcaggttc  tcgtagggg  720
gaatacaat  tttacagca  attccagag  catgaaccc  agttcgatt  cctgaagag  780
ttagaaata  aagaaaaaa  caataaaat  agatggctc  cccagcaga  tgcagctta  840
tttcttctg  ctactaatg  taaaactgt  aagctgtgg  aagtcagcg  gcgtgataa  900
aggccagaa  gctacaatc  gaaagatga  gagggccgg  tccgggatc  tgccaccat  960
acaaccctg  gggtgcctg  cctgagacc  atggacctg  tggtggagg  caccccacg  1020
agagtattt  ccaacgcac  cacatatca  atcaactcc  tatctgtca  cagcgacta  1080
gaaacctac  tgtccgctg  tgacctgag  attaaccta  ggaactttg  aataaccaa  1140
caaagtttt  atattgtgg  cattaagcc  gccaacatg  aggagctca  ggaggtgat  1200
acagcagcc  agttccacc  ccatcattg  aacaccttc  tgtacagca  cagcaaagg  1260
acaatccgg  tgtgtgaca  gcgggcatc  gccctgtgt  acaggcaca  caaattttt  1320
gaagagccg  aagatccaa  caacagatc  tttttctct  aaattatct  ttcgatttc  1380
gatgtgaag  tcagccaca  tgggaggta  atcatgacc  gggactact  gaccgtcaa  1440
gtctgggat  tcaacatgg  aaaccgccc  atcgagact  accaggttc  tgactacct  1500
cgcagcaag  tgtgttccc  ctatgaaaa  gactgcatt  ttgataaat  tgagtgtgt  1560
tggaatggg  cagacagtg  catcatgac  ggctcctac  acaacttct  caggatgtt  1620
gacagaaac  ccaagcgtg  tgtgaccct  gaggcttcg  gggaaaaca  caagccccg  1680
gctatcctc  aaccccgaa  agtgtgtgt  gggggcaag  ggagaaaag  cgagatcag  1740
gtcgacagt  tggacttta  caaaaagat  ttgcataca  cttggcatc  ttcagaaaa  1800
attatagca  tggcggcta  aaataacct  tatatattc  aggacaagg  taactaggt  1860
gacaagtta  tacttaata  tctcacata  tgaatacta  tcaaacaag  ttttaaatg  1920
ttctttggg  cttcatttg  tgcattgac  ttaatttcc  tatacagga  atgattgga  1980
tagaattaa  aggagtcca  cattcccag  tccccagtt  taagaaact  ttgtcaaac  2040
caataggtt  gggacactt  tgtttagaa  tgaaagctg  cagctaaca  taattcttc  2100
atagttgac  tgaacttct  atgctttta  tgcccagtt  tctctggtg  gtccagtgt  2160
ttgttccta  gtgtctgct  cgataaaat  aggttgtct  tagtattta  ggagaaaag  2220
gataagttt  ttttaatta  gcaattcca  ttgattgaa  aaaatcaac  aaaaataaa  2280
accgtttac  cttagacaa  ttcttcttg  tttgtgaaa  accagaact  gtcagtatc  2340
cctgcccct  caccatttt  ttttccatt  tccattttc  tttgaacaa  ttcatttaa  2400
ccagagatt  attgcatga  gctgagaag  ggatgcaga  tgacaagga  agggcacat  2460
aaccctgct  tgctctttt  ttgtaagct  catagaaac  gcctgagaa  ttggctagg  2520
aacttgaat  cttcagggg  cagaaagag  gcactttcg  cacagtgct  cccagagtg  2580
gcttggcag  gccaggcgg  gccaaattc  atctgctgc  ttgttactc  tgctttttg  2640
gctcttaaa  ggctccata  aatcttcta  ttacatgtt  cttggcttt  ttctcttca  2700
ccttttcca  cttatttat  ccattgact  ctaaaggcc  agtcctggg  gcttattat  2760
tggtgttct  aatgaagca  taagttgga  gcagtgcca  cacccctga  tccctgaga  2820
aggctggtc  gttcttttt  ggtgtttct  ctaagcagc  ccctcccct  ctcctggtt  2880
tggtaacca  aagtaacaa  ccatcaacc  ccattgtac  tagaacaaa  atagccaat  2940
aaaacgctg  gttgtgaag  ccaatcagg  acttctaac  caccccaag  tcgccatct  3000
gaaaaacag  ccagaaggc  tctcttcta  agaaatgaa  tgtggggaa  tcaagcagc  3060
gtgacatga  gtgaatgaa  tccacttga  gctgtggaa  atggttcat  cttttcccc  3120
gttgaggat  cagatttat  acttctaga  agccatttc  agaaggttc  atgtggcac  3180
cccctagga  aggcactaa  tgcatgcaa  ggatttata  acttaggaa  gtagatggg  3240
ggagtccag  aaactggtt  tgggttaat  tctctacat  tgtcttgat  actcatttc  3300
cctaactcc  atttagtgc  gggtaaatg  tttgagatg  gagtttttc  atgaaaggg  3360
aattttctt  cagtttaca  atgtattag  agtcctgac  ttcaagtgt  atttgcttt  3420
gaggaggaa  aaaaaaaaa  a  3441



<210> 1754
<211> 443
<212> PRT
<213> Homo sapiens
<308> NP_004567
<400> 1754

Met Glu Glu Asp Ile Asp Thr Arg Lys Ile Asn Asn Ser Phe Leu Arg 
  1               5                  10                  15
Asp His Ser Tyr Ala Thr Glu Ala Asp Ile Ile Ser Thr Val Glu Phe 
             20                  25                  30
Asn His Thr Gly Glu Leu Leu Ala Thr Gly Asp Lys Gly Gly Arg Val 
         35                  40                  45
Val Ile Phe Gln Arg Glu Gln Glu Ser Lys Asn Gln Val His Arg Arg 
     50                  55                  60
Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His Glu Pro Glu Phe 
 65                  70                  75                  80
Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile Asn Lys Ile Arg 
                 85                  90                  95
Trp Leu Pro Gln Gln Asn Ala Ala Tyr Phe Leu Leu Ser Thr Asn Asp 
             100                105                110
Lys Thr Val Lys Leu Trp Lys Val Ser Glu Arg Asp Lys Arg Pro Glu 
         115                120                125
Gly Tyr Asn Leu Lys Asp Glu Glu Gly Arg Leu Arg Asp Pro Ala Thr 
     130                135                140
Ile Thr Thr Leu Arg Val Pro Val Leu Arg Pro Met Asp Leu Met Val 
 145                150                155                160
Glu Ala Thr Pro Arg Arg Val Phe Ala Asn Ala His Thr Tyr His Ile 
                 165                170                175
Asn Ser Ile Ser Val Asn Ser Asp Tyr Glu Thr Tyr Met Ser Ala Asp 
             180                185                190
Asp Leu Arg Ile Asn Leu Trp Asn Phe Glu Ile Thr Asn Gln Ser Phe 
         195                200                205
Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu Leu Thr Glu Val 
     210                215                220
Ile Thr Ala Ala Glu Phe His Pro His His Cys Asn Thr Phe Val Tyr 
 225                230                235                240
Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met Arg Ala Ser Ala 
                 245                250                255
Leu Cys Asp Arg His Thr Lys Phe Phe Glu Glu Pro Glu Asp Pro Ser 
             260                265                270
Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile Ser Asp Val Lys 
         275                280                285
Phe Ser His Ser Gly Arg Tyr Ile Met Thr Arg Asp Tyr Leu Thr Val 
     290                295                300
Lys Val Trp Asp Leu Asn Met Glu Asn Arg Pro Ile Glu Thr Tyr Gln 
 305                310                315                320
Val His Asp Tyr Leu Arg Ser Lys Leu Cys Ser Leu Tyr Glu Asn Asp 
                 325                330                335
Cys Ile Phe Asp Lys Phe Glu Cys Val Trp Asn Gly Ser Asp Ser Val 
             340                345                350
Ile Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met Phe Asp Arg Asn 
         355                360                365
Thr Lys Arg Asp Val Thr Leu Glu Ala Ser Arg Glu Asn Ser Lys Pro 
     370                375                380
Arg Ala Ile Leu Lys Pro Arg Lys Val Cys Val Gly Gly Lys Arg Arg 
 385                390                395                400
Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Ser Lys Lys Ile Leu 
                 405                410                415
His Thr Ala Trp His Pro Ser Glu Asn Ile Ile Ala Val Ala Ala Thr 
             420                425                430
Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440



<210> 1755
<211> 512
<212> DNA
<213> Rattus norvegicus
<308> D14421
<400> 1755

ccgcaaaat  aacaacagt  tcctgcgcg  ccacagcta  gcaaccgaa  ctgacatta  60
ctctacggt  gaattcaac  acactggag  gttactagc  acgggggac  aggggggta  120
ggttgtaat  tttcagcga  aacaggaga  taaaaatca  gttcatcgt  ggggtgaat  180
caatgttta  agcacattc  agagccatg  acccgagtt  gattacctg  aaagtttag  240
aatagaaga  aaaatcaat  aaataagat  gctccctca  caaaatgca  cttactttc  300
tctgtctac  aacgataaa  ctgtgaagc  atggaaagt  agtgagcgt  ataagaggc  360
agaaggcta  aacctgaaa  atgaggagg  ccggctccg  gatcctgcc  ccatcacaa  420
cctgcgggt  cctgtcctg  gacccatgg  cttgatggt  gaggccacc  cacgaagag  480
gtttgccaa  gcgcacaca  accacatca  ct  512



<210> 1756
<211> 443
<212> PRT
<213> Rattus norvegicus
<308> BAA03313
<400> 1756

Met Glu Glu Asp Ile Asp Thr Arg Lys Ile Asn Asn Ser Phe Leu Arg 
  1               5                  10                  15
Asp His Ser Tyr Ala Thr Glu Ala Asp Ile Ile Ser Thr Val Glu Phe 
             20                  25                  30
Asn His Thr Gly Glu Leu Leu Ala Thr Gly Asp Lys Gly Gly Arg Val 
         35                  40                  45
Val Ile Phe Gln Arg Glu Gln Glu Ser Lys Asn Gln Val His Arg Arg 
     50                  55                  60
Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His Glu Pro Glu Phe 
 65                  70                  75                  80
Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile Asn Lys Ile Arg 
                 85                  90                  95
Trp Leu Pro Gln Gln Asn Ala Ala Tyr Phe Leu Leu Ser Thr Asn Asp 
             100                105                110
Lys Thr Val Lys Leu Trp Lys Val Ser Glu Arg Asp Lys Arg Pro Glu 
         115                120                125
Gly Tyr Asn Leu Lys Asp Glu Glu Gly Arg Leu Arg Asp Pro Ala Thr 
     130                135                140
Ile Thr Thr Leu Arg Val Pro Val Leu Arg Pro Met Asp Leu Met Val 
 145                150                155                160
Glu Ala Thr Pro Arg Arg Val Phe Ala Asn Ala His Thr Tyr His Ile 
                 165                170                175
Asn Ser Ile Ser Val Asn Ser Asp Tyr Glu Thr Tyr Met Ser Ala Asp 
             180                185                190
Asp Leu Arg Ile Asn Leu Trp Asn Phe Glu Ile Thr Asn Gln Ser Phe 
         195                200                205
Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu Leu Thr Glu Val 
     210                215                220
Ile Thr Ala Ala Glu Phe His Pro His His Cys Asn Thr Phe Val Tyr 
 225                230                235                240
Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met Arg Ala Ser Ala 
                 245                250                255
Leu Cys Asp Arg His Thr Lys Phe Phe Glu Glu Pro Glu Asp Pro Ser 
             260                265                270
Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile Ser Asp Val Lys 
         275                280                285
Phe Ser His Ser Gly Arg Tyr Ile Met Thr Arg Asp Tyr Leu Thr Ala 
     290                295                300
Lys Val Trp Asp Leu Asn Met Glu Asn Arg Pro Val Glu Thr Tyr Gln 
 305                310                315                320
Val His Asp Tyr Leu Arg Ser Lys Leu Cys Ser Leu Tyr Glu Asn Asp 
                 325                330                335
Cys Ile Phe Asp Lys Phe Glu Cys Val Trp Asn Gly Ser Asp Ser Val 
             340                345                350
Ile Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met Phe Asp Arg Asn 
         355                360                365
Thr Lys Arg Asp Val Thr Leu Glu Ala Ser Arg Glu Asn Ser Lys Pro 
     370                375                380
Arg Ala Ile Leu Lys Pro Arg Lys Val Cys Val Gly Gly Lys Arg Arg 
 385                390                395                400
Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Ser Lys Lys Ile Leu 
                 405                410                415
His Thr Ala Trp His Pro Ser Glu Asn Ile Ile Ala Val Ala Ala Thr 
             420                425                430
Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440



<210> 1757
<211> 3441
<212> DNA
<213> Homo sapiens
<308> NM_004576
<400> 1757

ggccaggca  gcctgaatc  tgtccctgc  atctcgcca  tgcagctcg  gtccagaaa  60
gcaccattt  gtcgcggct  cccgctctc  cagggggag  agggatctt  tttgcattt  120
ggagcggct  ccaaggagg  gaacctgtt  ggcatctcc  cagacccgc  tgtgagcgc  180
tccggggcg  gcgggcggg  ccagacccc  cggggcacg  cgtatcttg  cacccggag  240
cagcggagg  aggcgcagc  tcctcgctg  gaactggag  tggagtgag  gcaccgcgc  300
ggaggagcc  ccgcagcct  gcagaaccc  agtggagga  gtgacagct  cattgccgg  360
tttttattt  ttttctctc  gcctccccg  ctcctcctc  ggctcggac  atggtgcag  420
cccactggc  cccctgccc  cctctcctg  gagactggc  gcggggagg  atcatggat  480
cttgtctgc  ggcttctgg  tcccacgca  gtaagcctg  tgtcaatgg  ggaggacat  540
gatacccgc  aaatcaaca  cagtttcct  cgcgaccac  gctatgcga  cgaagctga  600
attatctct  cggtagaat  caaccacac  ggagaatta  tagcgacag  ggacaaggg  660
ggtcgggtt  taatatttc  acgagagca  gagagtaaa  atcaggttc  tcgtagggg  720
gaatacaat  tttacagca  attccagag  catgaaccc  agttcgatt  cctgaagag  780
ttagaaata  aagaaaaaa  caataaaat  agatggctc  cccagcaga  tgcagctta  840
tttcttctg  ctactaatg  taaaactgt  aagctgtgg  aagtcagcg  gcgtgataa  900
aggccagaa  gctacaatc  gaaagatga  gagggccgg  tccgggatc  tgccaccat  960
acaaccctg  gggtgcctg  cctgagacc  atggacctg  tggtggagg  caccccacg  1020
agagtattt  ccaacgcac  cacatatca  atcaactcc  tatctgtca  cagcgacta  1080
gaaacctac  tgtccgctg  tgacctgag  attaaccta  ggaactttg  aataaccaa  1140
caaagtttt  atattgtgg  cattaagcc  gccaacatg  aggagctca  ggaggtgat  1200
acagcagcc  agttccacc  ccatcattg  aacaccttc  tgtacagca  cagcaaagg  1260
acaatccgg  tgtgtgaca  gcgggcatc  gccctgtgt  acaggcaca  caaattttt  1320
gaagagccg  aagatccaa  caacagatc  tttttctct  aaattatct  ttcgatttc  1380
gatgtgaag  tcagccaca  tgggaggta  atcatgacc  gggactact  gaccgtcaa  1440
gtctgggat  tcaacatgg  aaaccgccc  atcgagact  accaggttc  tgactacct  1500
cgcagcaag  tgtgttccc  ctatgaaaa  gactgcatt  ttgataaat  tgagtgtgt  1560
tggaatggg  cagacagtg  catcatgac  ggctcctac  acaacttct  caggatgtt  1620
gacagaaac  ccaagcgtg  tgtgaccct  gaggcttcg  gggaaaaca  caagccccg  1680
gctatcctc  aaccccgaa  agtgtgtgt  gggggcaag  ggagaaaag  cgagatcag  1740
gtcgacagt  tggacttta  caaaaagat  ttgcataca  cttggcatc  ttcagaaaa  1800
attatagca  tggcggcta  aaataacct  tatatattc  aggacaagg  taactaggt  1860
gacaagtta  tacttaata  tctcacata  tgaatacta  tcaaacaag  ttttaaatg  1920
ttctttggg  cttcatttg  tgcattgac  ttaatttcc  tatacagga  atgattgga  1980
tagaattaa  aggagtcca  cattcccag  tccccagtt  taagaaact  ttgtcaaac  2040
caataggtt  gggacactt  tgtttagaa  tgaaagctg  cagctaaca  taattcttc  2100
atagttgac  tgaacttct  atgctttta  tgcccagtt  tctctggtg  gtccagtgt  2160
ttgttccta  gtgtctgct  cgataaaat  aggttgtct  tagtattta  ggagaaaag  2220
gataagttt  ttttaatta  gcaattcca  ttgattgaa  aaaatcaac  aaaaataaa  2280
accgtttac  cttagacaa  ttcttcttg  tttgtgaaa  accagaact  gtcagtatc  2340
cctgcccct  caccatttt  ttttccatt  tccattttc  tttgaacaa  ttcatttaa  2400
ccagagatt  attgcatga  gctgagaag  ggatgcaga  tgacaagga  agggcacat  2460
aaccctgct  tgctctttt  ttgtaagct  catagaaac  gcctgagaa  ttggctagg  2520
aacttgaat  cttcagggg  cagaaagag  gcactttcg  cacagtgct  cccagagtg  2580
gcttggcag  gccaggcgg  gccaaattc  atctgctgc  ttgttactc  tgctttttg  2640
gctcttaaa  ggctccata  aatcttcta  ttacatgtt  cttggcttt  ttctcttca  2700
ccttttcca  cttatttat  ccattgact  ctaaaggcc  agtcctggg  gcttattat  2760
tggtgttct  aatgaagca  taagttgga  gcagtgcca  cacccctga  tccctgaga  2820
aggctggtc  gttcttttt  ggtgtttct  ctaagcagc  ccctcccct  ctcctggtt  2880
tggtaacca  aagtaacaa  ccatcaacc  ccattgtac  tagaacaaa  atagccaat  2940
aaaacgctg  gttgtgaag  ccaatcagg  acttctaac  caccccaag  tcgccatct  3000
gaaaaacag  ccagaaggc  tctcttcta  agaaatgaa  tgtggggaa  tcaagcagc  3060
gtgacatga  gtgaatgaa  tccacttga  gctgtggaa  atggttcat  cttttcccc  3120
gttgaggat  cagatttat  acttctaga  agccatttc  agaaggttc  atgtggcac  3180
cccctagga  aggcactaa  tgcatgcaa  ggatttata  acttaggaa  gtagatggg  3240
ggagtccag  aaactggtt  tgggttaat  tctctacat  tgtcttgat  actcatttc  3300
cctaactcc  atttagtgc  gggtaaatg  tttgagatg  gagtttttc  atgaaaggg  3360
aattttctt  cagtttaca  atgtattag  agtcctgac  ttcaagtgt  atttgcttt  3420
gaggaggaa  aaaaaaaaa  a  3441



<210> 1758
<211> 443
<212> PRT
<213> Homo sapiens
<308> NP_004567
<400> 1758

Met Glu Glu Asp Ile Asp Thr Arg Lys Ile Asn Asn Ser Phe Leu Arg 
  1               5                  10                  15
Asp His Ser Tyr Ala Thr Glu Ala Asp Ile Ile Ser Thr Val Glu Phe 
             20                  25                  30
Asn His Thr Gly Glu Leu Leu Ala Thr Gly Asp Lys Gly Gly Arg Val 
         35                  40                  45
Val Ile Phe Gln Arg Glu Gln Glu Ser Lys Asn Gln Val His Arg Arg 
     50                  55                  60
Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His Glu Pro Glu Phe 
 65                  70                  75                  80
Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile Asn Lys Ile Arg 
                 85                  90                  95
Trp Leu Pro Gln Gln Asn Ala Ala Tyr Phe Leu Leu Ser Thr Asn Asp 
             100                105                110
Lys Thr Val Lys Leu Trp Lys Val Ser Glu Arg Asp Lys Arg Pro Glu 
         115                120                125
Gly Tyr Asn Leu Lys Asp Glu Glu Gly Arg Leu Arg Asp Pro Ala Thr 
     130                135                140
Ile Thr Thr Leu Arg Val Pro Val Leu Arg Pro Met Asp Leu Met Val 
 145                150                155                160
Glu Ala Thr Pro Arg Arg Val Phe Ala Asn Ala His Thr Tyr His Ile 
                 165                170                175
Asn Ser Ile Ser Val Asn Ser Asp Tyr Glu Thr Tyr Met Ser Ala Asp 
             180                185                190
Asp Leu Arg Ile Asn Leu Trp Asn Phe Glu Ile Thr Asn Gln Ser Phe 
         195                200                205
Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu Leu Thr Glu Val 
     210                215                220
Ile Thr Ala Ala Glu Phe His Pro His His Cys Asn Thr Phe Val Tyr 
 225                230                235                240
Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met Arg Ala Ser Ala 
                 245                250                255
Leu Cys Asp Arg His Thr Lys Phe Phe Glu Glu Pro Glu Asp Pro Ser 
             260                265                270
Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile Ser Asp Val Lys 
         275                280                285
Phe Ser His Ser Gly Arg Tyr Ile Met Thr Arg Asp Tyr Leu Thr Val 
     290                295                300
Lys Val Trp Asp Leu Asn Met Glu Asn Arg Pro Ile Glu Thr Tyr Gln 
 305                310                315                320
Val His Asp Tyr Leu Arg Ser Lys Leu Cys Ser Leu Tyr Glu Asn Asp 
                 325                330                335
Cys Ile Phe Asp Lys Phe Glu Cys Val Trp Asn Gly Ser Asp Ser Val 
             340                345                350
Ile Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met Phe Asp Arg Asn 
         355                360                365
Thr Lys Arg Asp Val Thr Leu Glu Ala Ser Arg Glu Asn Ser Lys Pro 
     370                375                380
Arg Ala Ile Leu Lys Pro Arg Lys Val Cys Val Gly Gly Lys Arg Arg 
 385                390                395                400
Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Ser Lys Lys Ile Leu 
                 405                410                415
His Thr Ala Trp His Pro Ser Glu Asn Ile Ile Ala Val Ala Ala Thr 
             420                425                430
Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440



<210> 1759
<211> 796
<212> DNA
<213> Rattus norvegicus
<308> D14568
<400> 1759

gaagatccg  gtacgccgc  tcccaagga  cctacagcc  ccgccagcg  cgcccgcct  60
gcaagatgg  aaatgaggc  agttaccct  tggaaatgt  ctcacactt  gatgctgat  120
agattaaaa  gctaggaaa  agattcaag  agcttgact  ggacaactc  ggttctttg  180
gcgtggagg  gttcatgtc  ctgcctgag  tacaacaga  ccctttagt  cagcgggtc  240
tagatatat  cgacacaga  gggaatgga  aagtggact  caaagaatt  attgaagga  300
tctctcagt  cagtgtcaa  ggcgataag  aacagaagt  gaggttcgc  ttccgtatc  360
acgacatgg  taaagacgg  tatatttcc  atggagagc  cttccaggt  ttgaagatg  420
tggtgggca  caacctgaa  gatacgcag  tacagcaga  tgtagacaa  accataata  480
acgcagata  ggacgggga  gggagaata  cctttgagg  gttctgtgc  gttgtaggt  540
gcctagata  ccacaaaaa  atggtggtg  atgtgtgac  ctttgaaga  tctaccacc  600
agcactttt  ctttcttct  catctctga  gatctgctc  agacgtcca  cagtgctct  660
tgtgtgtgt  aatggaagt  tttttctct  tgaagccac  ttttccaac  tgagcctca  720
gaagccaac  aagtgttat  gaactccta  cctctcaat  actcagtgt  gcactttca  780
gtttgaggc  atggtg  796



<210> 1760
<211> 169
<212> PRT
<213> Rattus norvegicus
<308> P06705
<400> 1760

Gly Asn Glu Ala Ser Tyr Pro Leu Glu Met Cys Ser His Phe Asp Ala 
  1               5                  10                  15
Asp Glu Ile Lys Arg Leu Gly Lys Arg Phe Lys Lys Leu Asp Leu Asp 
             20                  25                  30
Asn Ser Gly Ser Leu Ser Val Glu Glu Phe Met Ser Leu Pro Glu Leu 
         35                  40                  45
Gln Gln Asn Pro Leu Val Gln Arg Val Ile Asp Ile Phe Asp Thr Asp 
     50                  55                  60
Gly Asn Gly Glu Val Asp Phe Lys Glu Phe Ile Glu Gly Val Ser Gln 
 65                  70                  75                  80
Phe Ser Val Lys Gly Asp Lys Glu Gln Lys Leu Arg Phe Ala Phe Arg 
                 85                  90                  95
Ile Tyr Asp Met Asp Lys Asp Gly Tyr Ile Ser Asn Gly Glu Leu Phe 
             100                105                110
Gln Val Leu Lys Met Met Val Gly Asn Asn Leu Lys Asp Thr Gln Leu 
         115                120                125
Gln Gln Ile Val Asp Lys Thr Ile Ile Asn Ala Asp Lys Asp Gly Asp 
     130                135                140
Gly Arg Ile Ser Phe Glu Glu Phe Cys Ala Val Val Gly Gly Leu Asp 
 145                150                155                160
Ile His Lys Lys Met Val Val Asp Val 
                 165



<210> 1761
<211> 2548
<212> DNA
<213> Homo sapiens
<308> M30773
<400> 1761

aggctgggg  acaaccaga  gccagggag  aagaggaga  agaggaagc  ccgagggtg  60
ctacgttgt  ttccctaga  caattttct  ctggatggc  cgtgctgag  ggtagatga  120
cgaatcgat  agtccagcc  ctgtgaaca  gcccccaat  atggcgcac  cacctgtca  180
gaagtgggt  aaggacctg  gcttctccg  cagcttcac  atcatgggc  agagctcat  240
gaggacgaa  actccggga  ggccttggt  gcccaacag  ccattggca  ccttctcat  300
tctggtcac  gagaactga  ttgtcctca  tacctctcc  tccaccttc  tgtacacag  360
gggcaccac  ttcacaaag  gctgtaaca  ctgtgaagg  agcggctcc  gcgcgagcg  420
gaggctgca  cccccgagt  tcccggccg  cttcgcccc  tctccccct  ctttcttct  480
ctctgcctc  cctgcctct  gccgctgct  ctcccgcgc  ctccggctc  gaatgtcga  540
cttaattta  ttcccccta  cctgcccgc  ccctcgcgt  cccaatcgc  cggccggcg  600
gggccccgc  cgccgcctc  ccctcccca  gcgcgcccc  tccccgccg  cgacccgag  660
gccgcagct  ggccgccgc  gccgtttcc  gcgagccag  ctgagcgca  cacttctcc  720
agccagcga  ccagcgagc  gccgacccg  cgagcaaaa  gggaaatga  gcaagttat  780
ctttggaaa  gtgctcaca  tttgatgcg  atgaaatta  aaggctagg  aagagattt  840
agaagcttg  tttggacaa  tctggttct  tgagtgtgg  agagttcat  tctctgcct  900
agttacaac  gaatccttt  gtacagcga  taatagata  attcgacac  gatgggaat  960
gagaagtag  ctttaaaga  ttcattgag  gcgtctctc  gttcagtgt  aaaggagat  1020
aggagcaga  attgaggtt  gctttccgt  tctatgaca  ggataaaga  ggctatatt  1080
ccaatgggg  actcttcca  gtattgaag  tgatggtgg  gaacaatct  aaagataca  1140
agttacagc  aattgtaga  aaaaccata  taaatgcag  taaggatgg  gatggaaga  1200
tatcctttg  agaattctg  gctgttgta  gtggcctag  tatccacaa  aagatggtg  1260
tagatgtgt  actcttatc  gagagtacc  cccaacact  ttgctttct  ctccatctc  1320
gaagatctg  tcaagacgt  cagcaatgc  ctctgtgta  ttaaatgga  gtatttttc  1380
ctgtgaagc  acattttcc  acatgagcc  catgaagcc  actaagtgt  attgaactg  1440
aattctctc  ataactcag  gtagcactt  aaagtctga  ggacagcaa  atgaaaaga  1500
catatcaat  tggtggaga  agggaaggg  ttggctttt  aatttattt  tcttcatct  1560
ttataacaa  aaagtatct  tatatacat  tgtaaatat  tatatatag  tatatgtag  1620
tttctatat  tgtagtagg  tggctttaa  ttaatatcc  tgattcaga  acaaaacaa  1680
agagtacaa  agtgccaag  agaacataa  acatcctta  ttttatttc  cacagtttt  1740
tatatagat  gaagactgt  caatttgag  cgggtgtta  gccagctat  ttccttttc  1800
tgtgctttc  cctttgaga  attgacaaa  catttgtta  cgtcctatt  tttacctta  1860
ttacatttt  gtaacaaag  agtctgtaa  tttatttat  cttatgaat  tatccaggg  1920
ctacttctc  ttgctgagc  gcttttaat  cacctctgc  tgaggagaa  gtctagttc  1980
ttgctactg  caagagcta  ttcttgtgt  catatagta  ctgcacagg  cttatagct  2040
cttcattct  ctactttgt  actaggagc  attgcattt  ttaaatgtc  ctcagtaac  2100
ttaagtgct  gttgtgatt  tatacataa  ggccagaag  tgtctgagg  aatcatgat  2160
gattgtatg  atcacttac  gaagaatac  tgaagtgat  atgtaacta  ttataaggg  2220
tatccattt  tttgattac  tgggtaaat  atttgtcat  aaacttgtg  ttgaatcat  2280
aattccctt  tttcaaaag  cttgcagct  atctaaaaa  ctggtgata  ttaatatgc  2340
tgtatgtat  taaacaccc  catatattt  tggtttaag  gtgagaaat  ttgctaatc  2400
atatgccac  gaagagcaa  attgtatcc  aatttatgc  acttaaatt  ctttaccac  2460
agggataga  catgcatac  ggttttttt  tcttgattt  cccatataa  tggtaatgg  2520
taacttaat  aatttgtgt  atataaaa  2548



<210> 1762
<211> 169
<212> PRT
<213> Homo sapiens
<308> P06705
<400> 1762

Gly Asn Glu Ala Ser Tyr Pro Leu Glu Met Cys Ser His Phe Asp Ala 
  1               5                  10                  15
Asp Glu Ile Lys Arg Leu Gly Lys Arg Phe Lys Lys Leu Asp Leu Asp 
             20                  25                  30
Asn Ser Gly Ser Leu Ser Val Glu Glu Phe Met Ser Leu Pro Glu Leu 
         35                  40                  45
Gln Gln Asn Pro Leu Val Gln Arg Val Ile Asp Ile Phe Asp Thr Asp 
     50                  55                  60
Gly Asn Gly Glu Val Asp Phe Lys Glu Phe Ile Glu Gly Val Ser Gln 
 65                  70                  75                  80
Phe Ser Val Lys Gly Asp Lys Glu Gln Lys Leu Arg Phe Ala Phe Arg 
                 85                  90                  95
Ile Tyr Asp Met Asp Lys Asp Gly Tyr Ile Ser Asn Gly Glu Leu Phe 
             100                105                110
Gln Val Leu Lys Met Met Val Gly Asn Asn Leu Lys Asp Thr Gln Leu 
         115                120                125
Gln Gln Ile Val Asp Lys Thr Ile Ile Asn Ala Asp Lys Asp Gly Asp 
     130                135                140
Gly Arg Ile Ser Phe Glu Glu Phe Cys Ala Val Val Gly Gly Leu Asp 
 145                150                155                160
Ile His Lys Lys Met Val Val Asp Val 
                 165



<210> 1763
<211> 1182
<212> DNA
<213> Rattus norvegicus
<308> D14591
<400> 1763

atgcccaag  agaagccga  gcccatcca  ctgaacccg  cccccgatg  ctccgcggt  60
aacgggacc  gctcggccg  gaccaacct  gaggccttg  agaagaagc  ggaggagct  120
gagctggat  agcagcagc  gaagcgcct  gaggccttt  tgacgcaga  gcagaaggt  180
ggagagttg  aggatgatg  ctttgagaa  atcagtgaa  tgggggctg  caatggtgg  240
gtggtgttc  aggtctccc  caagccatc  ggcctggtt  tggctagga  gctaattca  300
ctggagatc  aacccgcaa  ccggaacca  atcatccgg  agctgcagg  gctgcatga  360
tgcaactcc  cgtacatag  gggcttcta  ggggccttc  acagtgacg  cgagatcag  420
atctgcatg  agcacatgg  tggtgggtc  ttggatcaa  tgctgaaga  agctggaag  480
attcctgag  aaattttag  aaaagtcag  atcgctgtg  taaaaggcc  gacatatct  540
cgagagaag  acaagatta  gcacagaga  gtcaagcct  ccaacattc  agtgaactc  600
cgtggggag  tcaaactct  cgattttgg  gtcagcggg  agctaattg  ctccatggc  660
aactccttc  tgggaacaa  gtcctacat  tcgcctgag  gactccagg  gactcacta  720
tctgtgcag  cggacatct  gagcatggg  ctctctctg  tggagatgg  agttggaag  780
taccccatt  ctcctcctg  tgccaagga  ctggagctg  tgtttggat  ccaggtgga  840
ggagacgcg  ccgaaacgc  acccaggcc  aggacccct  ggaggcccc  cagctcata  900
ggaatggat  gccgacctc  catggcaat  tttgagttg  tggattaca  cgtcaatga  960
cctcctcca  aactgccca  tggagtatt  agtctggaa  ttcaggatt  tgtgaataa  1020
tgcttaata  agaaccctg  agagagagc  gatctgaag  agctcatgg  acatgcttt  1080
atcaagaga  ctgatgccg  ggaggtaga  ttcgcaggc  ggctctgct  caccattgg  1140
cttaaccag  ccagcacac  aacccacgc  gccagcatc  ga  1182



<210> 1764
<211> 392
<212> PRT
<213> Rattus norvegicus
<308> Q01986
<400> 1764

Pro Lys Lys Lys Pro Thr Pro Ile Gln Leu Asn Pro Ala Pro Asp Gly 
  1               5                  10                  15
Ser Ala Val Asn Gly Thr Ser Ser Ala Glu Thr Asn Leu Glu Ala Leu 
             20                  25                  30
Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu Gln Gln Arg Lys Arg 
         35                  40                  45
Leu Glu Ala Phe Leu Thr Gln Lys Gln Lys Val Gly Glu Leu Lys Asp 
     50                  55                  60
Asp Asp Phe Glu Lys Ile Ser Glu Leu Gly Ala Gly Asn Gly Gly Val 
 65                  70                  75                  80
Val Phe Lys Val Ser His Lys Pro Ser Gly Leu Val Met Ala Arg Lys 
                 85                  90                  95
Leu Ile His Leu Glu Ile Lys Pro Ala Ile Arg Asn Gln Ile Ile Arg 
             100                105                110
Glu Leu Gln Val Leu His Glu Cys Asn Ser Pro Tyr Ile Val Gly Phe 
         115                120                125
Tyr Gly Ala Phe Tyr Ser Asp Gly Glu Ile Ser Ile Cys Met Glu His 
     130                135                140
Met Asp Gly Gly Ser Leu Asp Gln Val Leu Lys Lys Ala Gly Arg Ile 
 145                150                155                160
Pro Glu Gln Ile Leu Gly Lys Val Ser Ile Ala Val Ile Lys Gly Leu 
                 165                170                175
Thr Tyr Leu Arg Glu Lys His Lys Ile Met His Arg Asp Val Lys Pro 
             180                185                190
Ser Asn Ile Leu Val Asn Ser Arg Gly Glu Ile Lys Leu Cys Asp Phe 
         195                200                205
Gly Val Ser Gly Gln Leu Ile Asp Ser Met Ala Asn Ser Phe Val Gly 
     210                215                220
Thr Arg Ser Tyr Met Ser Pro Glu Arg Leu Gln Gly Thr His Tyr Ser 
 225                230                235                240
Val Gln Ser Asp Ile Trp Ser Met Gly Leu Ser Leu Val Glu Met Ala 
                 245                250                255
Val Gly Arg Tyr Pro Ile Pro Pro Pro Asp Ala Lys Glu Leu Glu Leu 
             260                265                270
Leu Phe Gly Cys Gln Val Glu Gly Asp Ala Ala Glu Thr Pro Pro Arg 
         275                280                285
Pro Arg Thr Pro Gly Arg Pro Leu Ser Ser Tyr Gly Met Asp Ser Arg 
     290                295                300
Pro Pro Met Ala Ile Phe Glu Leu Leu Asp Tyr Ile Val Asn Glu Pro 
 305                310                315                320
Pro Pro Lys Leu Pro Ser Gly Val Phe Ser Leu Glu Phe Gln Asp Phe 
                 325                330                335
Val Asn Lys Cys Leu Ile Lys Asn Pro Ala Glu Arg Ala Asp Leu Lys 
             340                345                350
Gln Leu Met Val His Ala Phe Ile Lys Arg Ser Asp Ala Glu Glu Val 
         355                360                365
Asp Phe Ala Gly Trp Leu Cys Ser Thr Ile Gly Leu Asn Gln Pro Ser 
     370                375                380
Thr Pro Thr His Ala Ala Ser Ile 
 385                390



<210> 1765
<211> 678
<212> DNA
<213> Homo sapiens
<308> BI549938
<400> 1765

agcggggag  gcggctagg  gcacggcgg  ggcggcact  tccccggca  gagctggag  60
tgggctctg  tgcgcgcgc  gctgtgccg  ccgagccgg  gggactggt  gttgagaga  120
agagaggaa  ggaatcccg  gctgccgaa  cgcacgttc  gcccgctcc  ctcctgcag  180
gcagccttt  ggctctctg  gcgcgaagc  gagtcccgg  cgggtgggg  gggggtcca  240
tgagaccgc  accggcccc  cggcgctga  gggaccgcg  ggggcgcac  cactgaagg  300
agccccggg  cccgcggcc  ggacttggt  ctgcgcagc  ggcgcgggg  agcgcagcg  360
gaggaagcg  gaggtgctg  cctcccccc  gagttggaa  cgcgttacc  gggtccaaa  420
tgcccaaga  gaagccgac  cccatccag  tgaacccgg  ccccgacgg  tctgcagtt  480
acgggacca  ctctgcgga  accaacttg  aggccttgc  gaagaagct  gaggagcta  540
agcttgatg  gcagcagcg  aagcgcctt  aggcctttc  tacccagaa  cagaaggtg  600
gagaactga  ggatgacga  tttgagaag  tcagtgagc  gggggctgg  aatggcggt  660
tggtgttca  ggtctccn  678



<210> 1766
<211> 392
<212> PRT
<213> Homo sapiens
<308> Q02750
<400> 1766

Pro Lys Lys Lys Pro Thr Pro Ile Gln Leu Asn Pro Ala Pro Asp Gly 
  1               5                  10                  15
Ser Ala Val Asn Gly Thr Ser Ser Ala Glu Thr Asn Leu Glu Ala Leu 
             20                  25                  30
Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu Gln Gln Arg Lys Arg 
         35                  40                  45
Leu Glu Ala Phe Leu Thr Gln Lys Gln Lys Val Gly Glu Leu Lys Asp 
     50                  55                  60
Asp Asp Phe Glu Lys Ile Ser Glu Leu Gly Ala Gly Asn Gly Gly Val 
 65                  70                  75                  80
Val Phe Lys Val Ser His Lys Pro Ser Gly Leu Val Met Ala Arg Lys 
                 85                  90                  95
Leu Ile His Leu Glu Ile Lys Pro Ala Ile Arg Asn Gln Ile Ile Arg 
             100                105                110
Glu Leu Gln Val Leu His Glu Cys Asn Ser Pro Tyr Ile Val Gly Phe 
         115                120                125
Tyr Gly Ala Phe Tyr Ser Asp Gly Glu Ile Ser Ile Cys Met Glu His 
     130                135                140
Met Asp Gly Gly Ser Leu Asp Gln Val Leu Lys Lys Ala Gly Arg Ile 
 145                150                155                160
Pro Glu Gln Ile Leu Gly Lys Val Ser Ile Ala Val Ile Lys Gly Leu 
                 165                170                175
Thr Tyr Leu Arg Glu Lys His Lys Ile Met His Arg Asp Val Lys Pro 
             180                185                190
Ser Asn Ile Leu Val Asn Ser Arg Gly Glu Ile Lys Leu Cys Asp Phe 
         195                200                205
Gly Val Ser Gly Gln Leu Ile Asp Ser Met Ala Asn Ser Phe Val Gly 
     210                215                220
Thr Arg Ser Tyr Met Ser Pro Glu Arg Leu Gln Gly Thr His Tyr Ser 
 225                230                235                240
Val Gln Ser Asp Ile Trp Ser Met Gly Leu Ser Leu Val Glu Met Ala 
                 245                250                255
Val Gly Arg Tyr Pro Ile Pro Pro Pro Asp Ala Lys Glu Leu Glu Leu 
             260                265                270
Met Phe Gly Cys Gln Val Glu Gly Asp Ala Ala Glu Thr Pro Pro Arg 
         275                280                285
Pro Arg Thr Pro Gly Arg Pro Leu Ser Ser Tyr Gly Met Asp Ser Arg 
     290                295                300
Pro Pro Met Ala Ile Phe Glu Leu Leu Asp Tyr Ile Val Asn Glu Pro 
 305                310                315                320
Pro Pro Lys Leu Pro Ser Gly Val Phe Ser Leu Glu Phe Gln Asp Phe 
                 325                330                335
Val Asn Lys Cys Leu Ile Lys Asn Pro Ala Glu Arg Ala Asp Leu Lys 
             340                345                350
Gln Leu Met Val His Ala Phe Ile Lys Arg Ser Asp Ala Glu Glu Val 
         355                360                365
Asp Phe Ala Gly Trp Leu Cys Ser Thr Ile Gly Leu Asn Gln Pro Ser 
     370                375                380
Thr Pro Thr His Ala Ala Gly Val 
 385                390



<210> 1767
<211> 1062
<212> DNA
<213> Rattus norvegicus
<308> D14688
<400> 1767

cctccgctg  aagcagtcg  cggtctggt  ctcttgtgc  tgcagttca  gtcagattt  60
aaccgccac  atgtcgagc  aaaaagcaa  gaccaagac  accaaaaag  gccctcagc  120
cgcaacgtc  aacgtgttc  ccatgtttg  ccagtccca  atccaggag  tcaaagagg  180
cttcaacat  atcgaccag  accgggacg  cttcattga  aaggaggac  tacacgaca  240
gctcgcgtc  ctggggaag  accccaccg  cgcctacct  gacgccatg  tgaacgagg  300
cccgggccc  atcaatttc  ccatgttcc  caccatgtt  ggagagaag  tgaacggca  360
cgacccaga  gacgtcatc  gaacacgct  cgcttgctt  gatgaggac  cgacaggca  420
catccagga  gattacctg  gggagctgc  gaccaccat  ggtgaccgc  tcacagatg  480
ggaagtgga  gagctgtac  gggaggccc  catcgacaa  aagggcaat  tcaactaca  540
cgagttcac  cgcatcctc  agcacggag  gaaagacaa  gatgactga  gagctgcag  600
tgacattcc  gttgagttt  cttattcac  tcatgtctc  gacacgcac  ccataggac  660
tactgtgtg  cactttgtc  ctcagacac  ccctcccat  gggcctact  tgtgccgct  720
agtccctca  acaccccct  ccatagggc  tactgtgtg  cacttagtc  ctcagacac  780
ccctcccat  gggcctact  tgtgccact  tgtccctca  acaccccct  ccataggac  840
tactgtgta  cacttggtt  ctcagacag  cccaccccc  aacccccta  ggacctact  900
cgggccact  agtttcaca  cctttcctc  tttttaatg  atttattcc  gaccctttc  960
gccacttag  atgtgtata  tcagactgg  atggggaca  tgttgtaaa  tgtactgaa  1020
atgagatgc  aataaaaaa  tcaaccaat  tgaaagccc  gg  1062



<210> 1768
<211> 171
<212> PRT
<213> Rattus norvegicus
<308> P18666
<400> 1768

Ser Ser Lys Lys Ala Lys Thr Lys Thr Thr Lys Lys Arg Pro Gln Arg 
  1               5                  10                  15
Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln Glu 
             20                  25                  30
Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe Ile 
         35                  40                  45
Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn Pro 
     50                  55                  60
Thr Asp Ala Tyr Leu Asp Ala Met Met Asn Glu Ala Pro Gly Arg Ile 
 65                  70                  75                  80
Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly Thr 
                 85                  90                  95
Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu Glu 
             100                105                110
Ala Thr Gly Thr Ile Gln Glu Asp Tyr Leu Arg Glu Leu Leu Thr Thr 
         115                120                125
Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Leu Tyr Arg Glu 
     130                135                140
Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Ile Glu Phe Thr Arg 
 145                150                155                160
Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
                 165                170



<210> 1769
<211> 932
<212> DNA
<213> Rattus norvegicus
<308> D14819
<400> 1769

gaattccat  atgcatgag  ttatgtaca  ctggaggtg  tctatgtcc  ctgtgtgct  60
ctcatgggg  gtccagaac  aggtgggtg  tgctccagc  tcagagtgg  agagccaga  120
gctgagcag  gccctcggg  gccaggagg  tctccgcgg  ctcagacgg  acacactcc  180
gcccagcta  gtgcgctgt  tccttcttg  gaggaaacc  gcctgattc  agattcttt  240
ctacttata  aagcaaata  tgatacaag  actggggag  cggcttcga  gcggaccct  300
cagagcctg  cgtccgccg  atagccagc  tcactcccc  cggacgctc  aggctccga  360
ccatctagc  actcggcga  cggcctcag  tggacaatc  tctggagag  ccgccttgg  420
ccagggact  tcacttcaa  ccgagtccc  agttcaaga  ggaggtacg  ccgcctcct  480
acccccagc  caggcccac  atggggaag  acaatagca  gctggcccc  gaggagctg  540
aagatctgg  ccagaacac  gagttcagc  agcaggagc  aaagcagtg  tataagggt  600
tcctgaagg  ctgccccag  ggcatcctc  acctggagg  gtttcagca  ctctacatc  660
agttctttc  ttacggaga  gcctccaag  ttgcacagc  tgctttccg  accttcgac  720
agaacggcg  tggcaccat  gacttccgg  agttcatct  cgccctttc  gtcacctcc  780
gtggcagct  tgagcagaa  ctcaactgg  cctttgaga  gtacgacct  gacggtgat  840
gacgcatca  acggctgga  atgctggag  tcattgagg  tatctataa  atggtgggc  900
ccgtgatca  gatgcgcat  aaccaggaa  tc  932



<210> 1770
<211> 144
<212> PRT
<213> Rattus norvegicus
<308> BAA03557
<400> 1770

Met Gly Lys Asn Asn Ser Lys Leu Ala Pro Glu Glu Leu Glu Asp Leu 
  1               5                  10                  15
Val Gln Asn Thr Glu Phe Ser Glu Gln Glu Leu Lys Gln Trp Tyr Lys 
             20                  25                  30
Gly Phe Leu Lys Asp Cys Pro Ser Gly Ile Leu Asn Leu Glu Glu Phe 
         35                  40                  45
Gln Gln Leu Tyr Ile Lys Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe 
     50                  55                  60
Ala Gln His Ala Phe Arg Thr Phe Asp Lys Asn Gly Asp Gly Thr Ile 
 65                  70                  75                  80
Asp Phe Arg Glu Phe Ile Cys Ala Leu Ser Val Thr Ser Arg Gly Ser 
                 85                  90                  95
Phe Glu Gln Lys Leu Asn Trp Ala Phe Glu Met Tyr Asp Leu Asp Gly 
             100                105                110
Asp Gly Arg Ile Thr Arg Leu Glu Met Leu Glu Ile Ile Glu Ala Ile 
         115                120                125
Tyr Lys Met Val Gly Thr Val Ile Met Met Arg Met Asn Gln Glu Phe 
     130                135                140



<210> 1771
<211> 4277
<212> DNA
<213> Homo sapiens
<308> NM_016257
<400> 1771

ggcggctcc  gcgcagacc  tggagagca  agctgccgg  ccgcgagcc  gcctcggtt  60
ccgcggccc  ccgaggctc  gagccatcc  gcgacccgg  gaccggcct  aggccccgc  120
atggggaag  ccaacagca  gctggcccc  gaggtgctg  aggaccttg  tcagaacac  180
gagttcagc  agcaggagc  gaagcagtg  tacaagggc  tcctgaagg  ctgccccag  240
ggcatcctc  acctggagg  gtttcagca  ctctacatc  agttcttcc  ctacggcga  300
gcctccaag  tcgcgcagc  cgctttccg  accttcgac  agaacggcg  cggcaccat  360
gacttccgg  agttcatct  cgccctgtc  gtcacctcc  gcggcagct  cgagcagaa  420
ctcaactgg  cctttgaga  gtacgacct  gacggcgac  ggcgcatca  gcgcctgga  480
atgctggag  tcatcgagg  aatctacaa  atggtgggc  ccgtgatca  gatgcgcat  540
aaccaggac  ggctcacgc  ccagcagcg  gtggacaag  tcttcaaga  gatggacca  600
gataaggac  accagatta  attggagga  ttcaaggag  cagccaaga  tgacccatc  660
attgtgttg  tgctgcagt  tgacatgca  aagtagaag  tggtgaggg  cagggtccc  720
ggccagaag  ggcatggcc  cctcccaac  tgatgacct  tctggctgg  ctcccagga  780
gagggacac  ccagccccc  tctctggcc  acccagtcc  ctgcccaag  ccttcctcc  840
ctccatcaa  atctttgag  gaccacctc  ccctgcaaa  gagacaggt  ctccagtac  900
ctgtcttct  gccccacct  ccacttggc  agaaccaat  tccattggg  ataggggag  960
tggcttttg  cccaggagg  gaggttaag  agttggggg  ctggggttc  ggttaggaa  1020
tctcttgat  ctgggatta  gctttatag  atgtggtcc  acaggcctg  cacagggcc  1080
aattgggtc  gtccattcc  gaggctcca  atcccataa  gggggtctc  tccccatcc  1140
ttctactct  cctggccct  ccagcccca  cctttggag  gttcattca  tcctttctt  1200
agctaatga  tactgagca  ctgtttggt  ctaaggata  ggtcattta  aagacacat  1260
ttgtgccct  tggaagctc  tagggttgt  aggcaaact  ccagccgtc  gggtctcag  1320
taagcagaa  gtgctggaa  gctggttag  ctgggagga  ctatttcat  ttccagctc  1380
gctccacac  aagctgcag  aggacgaaa  gaaaagcat  tggaagttt  ggagccacg  1440
gagtgaaag  tttaagaaa  atgaaattt  tgtcatact  attttttta  tacccttta  1500
aggagctac  gtcatttta  tatttcagg  ggttaaaat  tactctata  tacttggtt  1560
attataaaa  gattaaatg  atagagaaa  tattaattt  caaggggaa  aaacctgag  1620
agaaaggga  aaaagacca  gaaatttac  agataacac  ttttaagac  aagtcctga  1680
ctgccactc  cagcagttt  tgctgcttc  gctcttcct  tttattacc  ttttcaatt  1740
aacaagcaa  tttctgcta  atacttact  cggttgggt  ctgacttca  ggacaggaa  1800
aagcaaggt  tgcaaagag  gaaactagt  tatattccg  atcttggta  ttcgtttct  1860
gattgggtt  agtttcaga  ctggacttg  tccttcact  ccacagaat  agaaagagc  1920
agaagaaaa  gctcacctg  ccactgttt  ggcacccag  cataattta  ggacgaaat  1980
cctaaaaat  tgccaggca  gctctgttt  agaggcttt  tctaacccc  aatcttaga  2040
ctgccaggt  gttcaacat  ttccaagtg  gctggttct  ctttccaat  cctgcttcc  2100
aattttgga  ccatgagct  tacagctgc  tgctttgac  gccggaaaa  ttaatcttg  2160
ttcttcatc  ggtctttct  ctgtacttg  gatcagaaa  tacctttga  gtgcagtga  2220
agttgattt  ctcttgaac  gccggtgaa  acagtctag  acacaggtg  tgtcagccc  2280
gggtgggag  aggaaatga  tgctgagcc  ggggcaggg  aattgcatc  gcaggaaag  2340
gatgcagca  gctcctcac  cctgagtgc  cacctgtcc  gcttctctg  aggtgaaaa  2400
tctggggga  gctgatcaa  agagcttgg  cccaagctc  actgggccc  tggaggtag  2460
aaggccact  ggttgctat  ctcttgctg  ggatagcaa  cactggttt  caaccactg  2520
gttgctatc  ttttgctat  ctcttgctc  tgaccagcc  tatggtgag  ctggggagt  2580
cacatcctc  ggcaggaac  agcagttgt  tatccagca  tgcctcaag  atgttgcat  2640
gctcccagg  gctggctat  aggtatgtc  tgtgcggtc  gtcagcatc  cagacacat  2700
gatgctcac  agcctggct  agctgggac  taaatcttc  ggtgaaaag  ttttcacta  2760
gtgaggttc  ttccctgca  atgctgaat  tagcctaat  cgcaaccac  cagaatttc  2820
tggctttca  aggcttgcc  tgtgcccca  ctcattcta  actcacatc  catggaggt  2880
aggattttc  cttcttttc  ctagacttg  aagctgaga  tcagagagg  agcatccct  2940
gtgcaagat  acatagtca  gaggtgaca  agggctaag  cttgaacca  ggctctaag  3000
ggatttctt  ttttcagag  ctcttccct  tccatttct  tgactaagc  gtgcagagg  3060
tgacagcag  gcaagttac  ttgatattc  tcctttata  gcttcctgc  aaaaagctt  3120
tgagattgt  gtcttccaa  aaaaatagg  gcttggttg  agtccccac  ttttcaagc  3180
ctcagtgtt  tgcctctgg  agctgtgct  acagctcag  gctgtcctg  gagtcctct  3240
actcagaac  ctcgaagca  cctgcattg  ctttaccca  catcatcgt  actaagaga  3300
acatgccta  ccatgaagg  gtgtttgat  actccaggc  tctggacac  catacccat  3360
ggtgatttt  gctcctcag  cccaatatt  tcagacagc  cagcagtgt  aacacacaa  3420
gccaggcca  gaactggga  caccatctt  ctgatggaa  gaacaacag  tggcccagg  3480
catgctcct  catactcct  ggtgtccca  ggactgtgt  ctcaggagc  ctgtggtag  3540
gcactggcc  tgccttgag  agagacaca  gtctcccgt  cctgcacca  ctgagagag  3600
cttgccaca  agcacaagg  tggcagaga  ttatgtatg  cttgcacag  cacaaaaat  3660
tacagacaa  caaaacatt  atatattca  actctcctt  aaattccaa  cttattgca  3720
caactctgt  aattgcaag  tcccagaat  tgccttctc  catactcta  cctcattca  3780
ccttttggg  taattgatg  gcatcttat  tcttatctc  aaaaattat  agcaaaggc  3840
acttcagat  gccacttta  tcctttcag  tgtagtcag  attatttaa  ttacctgta  3900
atcaaaagt  aagaaaaag  tagttcata  gtaaaggca  taaatcctt  cctgacaat  3960
gcagagtct  tagaggtag  aatttgcct  gctgcagag  gagaaggaa  ggcgtggga  4020
gggggaaag  aaagaaaga  aagaagctg  ggtctccag  cagggtagt  agctgacac  4080
aaatatttt  tacacaaaa  tgtattgaa  caacaaata  ttcctgaag  tccaccctg  4140
gtgaggctt  gagctgact  tagagatca  tgtggggtc  agaatgtct  acatgtttt  4200
ttcatcatt  ttgaaaaaa  aaataattc  aaccttgga  ttaaaaagt  agaaaaata  4260
aaaaaaaaa  aaaaaaa  4277



<210> 1772
<211> 191
<212> PRT
<213> Homo sapiens
<308> NP_057341
<400> 1772

Met Gly Lys Thr Asn Ser Lys Leu Ala Pro Glu Val Leu Glu Asp Leu 
  1               5                  10                  15
Val Gln Asn Thr Glu Phe Ser Glu Gln Glu Leu Lys Gln Trp Tyr Lys 
             20                  25                  30
Gly Phe Leu Lys Asp Cys Pro Ser Gly Ile Leu Asn Leu Glu Glu Phe 
         35                  40                  45
Gln Gln Leu Tyr Ile Lys Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe 
     50                  55                  60
Ala Gln His Ala Phe Arg Thr Phe Asp Lys Asn Gly Asp Gly Thr Ile 
 65                  70                  75                  80
Asp Phe Arg Glu Phe Ile Cys Ala Leu Ser Val Thr Ser Arg Gly Ser 
                 85                  90                  95
Phe Glu Gln Lys Leu Asn Trp Ala Phe Glu Met Tyr Asp Leu Asp Gly 
             100                105                110
Asp Gly Arg Ile Thr Arg Leu Glu Met Leu Glu Ile Ile Glu Ala Ile 
         115                120                125
Tyr Lys Met Val Gly Thr Val Ile Met Met Arg Met Asn Gln Asp Gly 
     130                135                140
Leu Thr Pro Gln Gln Arg Val Asp Lys Ile Phe Lys Lys Met Asp Gln 
 145                150                155                160
Asp Lys Asp Asp Gln Ile Thr Leu Glu Glu Phe Lys Glu Ala Ala Lys 
                 165                170                175
Ser Asp Pro Ser Ile Val Leu Leu Leu Gln Cys Asp Met Gln Lys 
             180                185                190



<210> 1773
<211> 1084
<212> DNA
<213> Rattus norvegicus
<308> D14839
<400> 1773

cctcgagat  cattgtgct  taaagttta  gcattggat  gattgaaga  aagaaccct  60
tttccctct  tgtctgcaa  tgcagcaag  gaggggagt  ggatatacc  cgcctagtg  120
ctcctggtt  ataccatca  tattgttta  tcttgtgat  aaaagccga  tcctctgat  180
gctccctta  gtgaagttg  gagctattt  ggtgtgcag  acgcggtac  gttcgggaa  240
gtaccggtg  tgccggtgg  cagtccggt  ttgctaagt  accacctgg  tcagtccga  300
gcagggggg  tgccccggg  acccgcagt  acggacttg  atcatttaa  ggggattct  360
aggcggagg  agctgtact  caggactgg  tttcactta  aaatcttcc  caacggtac  420
atccaggga  ccaggaaag  ccacagccg  ttcggcatt  tggaattta  cagtatagc  480
gtgggcctg  tcagcattc  tggtgtgga  agtggactc  acctcggca  gaacgagaa  540
ggggagctg  atggatcag  aaaactaac  caggagtgc  tgttcagag  acagtttga  600
gaaaactgg  acaacacct  ctcttccaa  ctgtacaag  acgtggaca  cggaaggag  660
tactatgtt  cattaaata  ggatgggac  ccaagagaa  ggaccagga  taaacggca  720
cagaaattt  cacattttt  acctagacc  gtggaccct  acaaagtac  tgaactata  780
aaggatatt  taagccaaa  ttgacaaag  cagtgtctt  acttgagcc  ttaaaacat  840
accactata  atgcttcat  cggtgggtt  ttattgatt  gcagtgccg  cacctcagc  900
ccactgttg  caaactttg  cgcatcgat  tgtatgatg  gagcttgga  gaggacttg  960
cgatttgct  tgcacttac  ggctggtcc  cctggaggg  tgcctaggg  cacttgctt  1020
atttattgt  aaagcaggg  gagaggctg  gggtgccga  ggttggcca  gagtgagta  1080
aggg  1084



<210> 1774
<211> 208
<212> PRT
<213> Rattus norvegicus
<308> P36364
<400> 1774

Met Ala Pro Leu Gly Glu Val Gly Ser Tyr Phe Gly Val Gln Asp Ala 
  1               5                  10                  15
Val Pro Phe Gly Asn Val Pro Val Leu Pro Val Asp Ser Pro Val Leu 
             20                  25                  30
Leu Ser Asp His Leu Gly Gln Ser Glu Ala Gly Gly Leu Pro Arg Gly 
         35                  40                  45
Pro Ala Val Thr Asp Leu Asp His Leu Lys Gly Ile Leu Arg Arg Arg 
     50                  55                  60
Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly 
 65                  70                  75                  80
Thr Ile Gln Gly Thr Arg Lys Asp His Ser Arg Phe Gly Ile Leu Glu 
                 85                  90                  95
Phe Ile Ser Ile Ala Val Gly Leu Val Ser Ile Arg Gly Val Asp Ser 
             100                105                110
Gly Leu Tyr Leu Gly Met Asn Glu Lys Gly Glu Leu Tyr Gly Ser Glu 
         115                120                125
Lys Leu Thr Gln Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp 
     130                135                140
Tyr Asn Thr Tyr Ser Ser Asn Leu Tyr Lys His Val Asp Thr Gly Arg 
 145                150                155                160
Arg Tyr Tyr Val Ala Leu Asn Lys Asp Gly Thr Pro Arg Glu Gly Thr 
                 165                170                175
Arg Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val 
             180                185                190
Asp Pro Asp Lys Val Pro Glu Leu Tyr Lys Asp Ile Leu Ser Gln Ser 
         195                200                205



<210> 1775
<211> 1420
<212> DNA
<213> Homo sapiens
<308> NM_002010
<400> 1775

tgaaacagc  gattacttt  atttatgca  ttaatggat  gaagaaaag  acctttttt  60
ttctctctc  ctctgcaac  gcagtaagg  aggggagtt  gatatacct  gcctaatat  120
tcctgggtt  acaccatca  tattgttta  tcttgtgct  caaaagccg  gtcctctga  180
ggctccctt  ggtgaagtt  ggaactatt  cggtgtgca  gatgcggta  cgtttggga  240
tgtgcccgt  ttgccggtg  acagcccgg  tttgttaag  gaccacctg  gtcagtccg  300
agcaggggg  ctccccagg  gacccgcag  cacggactt  gatcattta  aggggattc  360
caggcggag  cagctatac  gcaggactg  atttcactt  gaaatcttc  ccaatggta  420
tatccaggg  accaggaaa  accacagcc  atttggcat  ctggaattt  tcagtatag  480
agtgggcct  gtcagcatt  gaggcgtgg  cagtggact  tacctcggg  tgaatgaga  540
gggggagct  tatggatca  aaaaactaa  ccaagagtg  gtattcaga  aacagttcg  600
agaaaactg  tataatacg  actcgtcaa  cctatataa  cacgtggac  ctggaaggc  660
atactatgt  gcattaaat  aagatggga  cccgagaga  gggactagg  ctaaacggc  720
ccagaaatt  acacatttt  tacctagac  agtggaccc  gacaaagta  ctgaactgt  780
taaggatat  ctaagccaa  gttgacaaa  acaatttct  cacttgagc  cttaaaaaa  840
taaccacta  aaaggtttc  cgcggtggg  tcttattga  tcgctgtgt  atcacatca  900
ctccactgt  gccaaactt  gtcgcatgc  taatgtatg  tggaggctt  gatgggaat  960
tgctgattt  gttctgcac  taaaggctt  tcctcctgg  gggctgcct  gggccactt  1020
cttgattta  catgagaga  gaggagaga  agagagact  agcgctagg  gtgtgtgta  1080
gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  atgtgtgta  cgggagatg  gggcggagc  1140
agagcaaaa  gactgcggc  tgatgcatg  tggaaaaaa  acacgcttt  catttctga  1200
cagttgtac  tcatcctat  tcagcacag  tgccatact  cgacttatc  ggattctgg  1260
tggtggcct  cgcgagggt  cagtcttac  taaaagact  tcagttaat  ctcactggt  1320
tcatcgcag  gaacttaaa  caaagacct  ttagtaaaa  ataaaaaaa  ataaaaaat  1380
aaaataaaa  aagttaaat  tatttatag  aattccaaaa  1420



<210> 1776
<211> 208
<212> PRT
<213> Homo sapiens
<308> P31371
<400> 1776

Met Ala Pro Leu Gly Glu Val Gly Asn Tyr Phe Gly Val Gln Asp Ala 
  1               5                  10                  15
Val Pro Phe Gly Asn Val Pro Val Leu Pro Val Asp Ser Pro Val Leu 
             20                  25                  30
Leu Ser Asp His Leu Gly Gln Ser Glu Ala Gly Gly Leu Pro Arg Gly 
         35                  40                  45
Pro Ala Val Thr Asp Leu Asp His Leu Lys Gly Ile Leu Arg Arg Arg 
     50                  55                  60
Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly 
 65                  70                  75                  80
Thr Ile Gln Gly Thr Arg Lys Asp His Ser Arg Phe Gly Ile Leu Glu 
                 85                  90                  95
Phe Ile Ser Ile Ala Val Gly Leu Val Ser Ile Arg Gly Val Asp Ser 
             100                105                110
Gly Leu Tyr Leu Gly Met Asn Glu Lys Gly Glu Leu Tyr Gly Ser Glu 
         115                120                125
Lys Leu Thr Gln Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp 
     130                135                140
Tyr Asn Thr Tyr Ser Ser Asn Leu Tyr Lys His Val Asp Thr Gly Arg 
 145                150                155                160
Arg Tyr Tyr Val Ala Leu Asn Lys Asp Gly Thr Pro Arg Glu Gly Thr 
                 165                170                175
Arg Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val 
             180                185                190
Asp Pro Asp Lys Val Pro Glu Leu Tyr Lys Asp Ile Leu Ser Gln Ser 
         195                200                205



<210> 1777
<211> 2546
<212> DNA
<213> Rattus norvegicus
<308> D16302
<400> 1777

ctccaggga  gcaacagag  gaagaaaag  aaggtacat  gctacttcc  actctcagc  60
tagaagaat  aacccttag  ttgcggggg  actgagcca  gcaagccac  ggcagcctt  120
agcgccccc  tgcctgccc  cccctgcgg  ggccaggat  ctgaagaag  agtctgcag  180
gcttgtgct  tggggtgct  tcatctttg  gggctggaa  gccctgctg  tcctcttct  240
ctggacacg  ccagcacct  gcaggctgc  ctcagacag  gcccttggt  atgaccctg  300
cagcctcac  cgtgaggtc  tccacctgg  cgaggacgc  gaggcggag  tggagcggc  360
gcggggact  ctgcagcag  tcaaggagc  ttattctct  tggaggcag  ggtggagag  420
tcccaccgt  gcccctcca  cctggcccc  tgtgcctgg  accccctca  cagctgtga  480
ccccattct  gtcattgcc  gtgaccgca  cactgtccg  cgctgcctg  ataagttgt  540
gcactatcg  ccctctgct  agcatttcc  cattattgt  agtcaagac  gtgggcatg  600
agagacagc  caggtcatt  cttcttatg  caccgctgt  acacacatc  ggcagccag  660
cctgagtaa  attgccgtg  agccagacc  ccgtaagtt  cagggttac  acaagattg  720
caggcacta  cgctgggcg  taggccaga  cttcaacaa  ttcaagttc  cggctgctg  780
ggtagtgga  gatgatctg  aagtggcgc  ggacttctt  gagtacttc  aggccacct  840
cccgctgct  aaagcagac  cctcccttt  gtgtgtgtc  gcttggaat  ataatggta  900
ggagcagat  gtggactcc  gcaaacctg  gctgctcta  cgaacagac  tttttcctg  960
ccttggatg  ctgctgttg  ctgatctct  ggcagaact  gagcccaag  ggcccaagg  1020
cttctggga  gactggatg  gcagacctg  gcagcggaa  gggcgggct  gtattcgtc  1080
agaaatttc  agaactatg  catttggtc  caagggtgt  agccatggg  agttctttg  1140
ccagcatct  aaattcatc  agctgaacc  gcagttcgt  cccttcacc  agttggacc  1200
gtcgtacct  cagcgggag  cctatgacc  ggacttcct  gcccaggtc  atggtgccc  1260
ccagctgca  gtggagaaa  tgaggacca  tgatcggaa  gaactgggg  aggtgcggg  1320
acagtacac  agcagagac  gctttaagg  ctttgctaa  gccctgggt  tcatggacg  1380
cctcaagtc  ggtgtcccc  gagctggct  ccgtggcat  gtcactttc  agttccggg  1440
tcggcgtgt  cacctggca  ccccagaga  atggaatgg  tatgatcct  gctggaatt  1500
gtggcacct  cctttccct  ctgggtctc  ttgccgtat  atgagccga  gcagcctgc  1560
ggccctggg  tataccatt  tgccagtgt  tcctcttgg  tctatagat  ttccctttt  1620
gtcctggcc  tcccccaag  ggcattcta  tgcacaaat  ataagatga  ggttatact  1680
ctcttgtca  gggagtact  tgtggtatg  tcggggcat  ttgaacaag  aaccactgt  1740
tggtgtggg  agggttgga  ctgttggac  aggcttgta  tgtcctgag  tctctccaa  1800
ggcatctgc  gagagcttg  ccactccag  tctcctgac  aggcctctc  accctgatc  1860
ggctcctgt  agtacatga  cccacttta  gtaccttcc  cactttctc  accttcccc  1920
gggtggggc  ggattatgg  agaaggaat  gatttgtgg  caactgaga  taaccaaag  1980
gattcactg  cagagttag  ttgcatggc  gggttgccg  ggtcactgc  tcctggctt  2040
tcttcctgc  gactttgcc  gtgctcttc  tgtcctgca  tggagcagt  tgttgtgag  2100
tggaaagta  gagctaaag  aagacctct  ccgtggtgg  gcagttgtc  ggaacaatg  2160
caggcggaa  gcctacact  gggcacccc  cttcttgcc  atggccccc  acttctgaa  2220
gttagttcc  tttgcattc  ttaggggga  tcagtggca  cctagtggg  gacagtggg  2280
tccacgcct  tttcccctg  ggttggtac  gcctcctcc  acagggctt  ttcctggtg  2340
ccatctcag  aaagtcacc  gcagctgag  ccaggacac  tgtggccct  cctaagcat  2400
cccacatct  cccaggccg  ggggcaggt  gcaggctag  gagaaagaa  tttgtgtgt  2460
ttgtttgtt  cctgatctt  gtttcatgg  agaaaatgg  atctacaga  ttattttca  2520
aaataaagt  aaggctgaa  tgtctg  2546



<210> 1778
<211> 447
<212> PRT
<213> Rattus norvegicus
<308> Q09325
<400> 1778

Met Leu Lys Lys Gln Ser Ala Gly Leu Val Leu Trp Gly Ala Ile Ile 
  1               5                  10                  15
Phe Val Gly Trp Asn Ala Leu Leu Leu Leu Phe Phe Trp Thr Arg Pro 
             20                  25                  30
Ala Pro Gly Arg Leu Pro Ser Asp Ser Ala Leu Gly Asp Asp Pro Ala 
         35                  40                  45
Ser Leu Thr Arg Glu Val Ile His Leu Ala Glu Asp Ala Glu Ala Glu 
     50                  55                  60
Leu Glu Arg Gln Arg Gly Leu Leu Gln Gln Ile Lys Glu His Tyr Ser 
 65                  70                  75                  80
Leu Trp Arg Gln Arg Trp Arg Val Pro Thr Val Ala Pro Pro Ala Trp 
                 85                  90                  95
Pro Arg Val Pro Gly Thr Pro Ser Pro Ala Val Ile Pro Ile Leu Val 
             100                105                110
Ile Ala Cys Asp Arg Ser Thr Val Arg Arg Cys Leu Asp Lys Leu Leu 
         115                120                125
His Tyr Arg Pro Ser Ala Glu His Phe Pro Ile Ile Val Ser Gln Asp 
     130                135                140
Cys Gly His Glu Glu Thr Ala Gln Val Ile Ala Ser Tyr Gly Thr Ala 
 145                150                155                160
Val Thr His Ile Arg Gln Pro Asp Leu Ser Asn Ile Ala Val Gln Pro 
                 165                170                175
Asp His Arg Lys Phe Gln Gly Tyr Tyr Lys Ile Ala Arg His Tyr Arg 
             180                185                190
Trp Ala Leu Gly Gln Ile Phe Asn Lys Phe Lys Phe Pro Ala Ala Val 
         195                200                205
Val Val Glu Asp Asp Leu Glu Val Ala Pro Asp Phe Phe Glu Tyr Phe 
     210                215                220
Gln Ala Thr Tyr Pro Leu Leu Lys Ala Asp Pro Ser Leu Trp Cys Val 
 225                230                235                240
Ser Ala Trp Asn Asp Asn Gly Lys Glu Gln Met Val Asp Ser Ser Lys 
                 245                250                255
Pro Glu Leu Leu Tyr Arg Thr Asp Phe Phe Pro Gly Leu Gly Trp Leu 
             260                265                270
Leu Leu Ala Asp Leu Trp Ala Glu Leu Glu Pro Lys Trp Pro Lys Ala 
         275                280                285
Phe Trp Asp Asp Trp Met Arg Arg Pro Glu Gln Arg Lys Gly Arg Ala 
     290                295                300
Cys Ile Arg Pro Glu Ile Ser Arg Thr Met Thr Phe Gly Arg Lys Gly 
 305                310                315                320
Val Ser His Gly Gln Phe Phe Asp Gln His Leu Lys Phe Ile Lys Leu 
                 325                330                335
Asn Gln Gln Phe Val Pro Phe Thr Gln Leu Asp Leu Ser Tyr Leu Gln 
             340                345                350
Arg Glu Ala Tyr Asp Arg Asp Phe Leu Ala Gln Val Tyr Gly Ala Pro 
         355                360                365
Gln Leu Gln Val Glu Lys Val Arg Thr Asn Asp Arg Lys Glu Leu Gly 
     370                375                380
Glu Val Arg Val Gln Tyr Thr Ser Arg Asp Ser Phe Lys Ala Phe Ala 
 385                390                395                400
Lys Ala Leu Gly Val Met Asp Asp Leu Lys Ser Gly Val Pro Arg Ala 
                 405                410                415
Gly Tyr Arg Gly Ile Val Thr Phe Gln Phe Arg Gly Arg Arg Val His 
             420                425                430
Leu Ala Pro Pro Glu Thr Trp Asn Gly Tyr Asp Pro Ser Trp Asn 
         435                440                445



<210> 1779
<211> 2937
<212> DNA
<213> Homo sapiens
<308> NM_002406
<400> 1779

gggttgcgc  agggagccg  aaagccgac  cccgaagtt  gggtcctgg  aaaacttgg  60
tcctgggtt  actgagaag  ggcggggaa  ggaggcggg  caggaggag  gggcctggc  120
gacgccggc  ggggggcgg  gcgcggcgg  gctgtcggt  acgcccctc  gtccgcccc  180
ccccgcccc  cctgccggg  aagggccac  ttgcccggc  cggccgtcc  gccccggcg  240
gccgcagaa  gggctggcg  gtcgaaagg  gaggcggcc  cggcagcgc  tgggacgcg  300
ctgggcacc  ggctcgctc  ctgcgcccc  gagcaggcc  agttcgggg  caggacgtc  360
ggaggacct  gtgcatggc  gcctcctaa  cccatagtc  agaggaggc  tccctagga  420
tgcgggcaa  ggagccggg  aagcccagg  cagccttga  ccgtcccct  gcctgccct  480
cccggtggg  gccaggatg  tgaagaagc  gtctgcagg  cttgtgctg  ggggcgcta  540
cctctttgt  gcctggaat  ccctgctgc  cctcttctt  tggacgcgc  cagcacctg  600
caggccacc  tcagtcagc  ctctcgatg  cgaccccgc  agcctcacc  gggaagtga  660
tcgcctggc  caagacgcc  aggtggagc  ggagcggca  cgtgggctg  tgcagcaga  720
cggggatgc  ctgtcgagc  agcggggga  ggtgcccac  gcggcccct  ccgcccagc  780
gcgtgtgcc  gtgaccccc  cgccggcgg  gattcccat  ctggtcatc  cctgtgacc  840
cagcactgt  cggcgctgc  tggacaagc  gctgcatta  cggccctcg  ctgagctct  900
ccccatcat  gttagccag  actgcgggc  cgaggagac  gcccaggcc  tcgcctcct  960
cggcagcgc  gtcacgcac  tccggcagc  cgacctgag  agcattgcg  tgccgccgg  1020
ccaccgcaa  ttccagggc  actacaaga  cgcgcgcca  taccgctgg  cgctgggcc  1080
ggtcttccg  cagtttcgc  tccccgcgg  cgtggtggt  gaggatgac  tggaggtgg  1140
cccggactt  ttcgagtac  ttcgggcca  ctatccgct  ctgaaggcc  acccctccc  1200
gtggtgcgt  tcggcctgg  atgacaacg  caaggagca  atggtggac  ccagcaggc  1260
tgagctgct  taccgcacc  actttttcc  tggcctggg  tggctgctg  tggccgagc  1320
ctgggctga  ctggagccc  agtggccaa  ggccttctg  gacgactgg  tgcggcggc  1380
ggagcagcg  caggggcgg  cctgcatac  ccctgagat  tcaagaacg  tgacctttg  1440
ccgcaaggg  gtgagccac  ggcagttct  tgaccagca  ctcaagttt  tcaagctga  1500
ccagcagtt  gtgcacttc  cccagctgg  cctgtctta  ctgcagcgg  aggcctatg  1560
ccgagattt  ctcgcccgc  tctacggtg  tccccagct  caggtggag  aagtgagga  1620
caatgaccg  aaggagctg  gggaggtgc  ggtgcagta  acgggcagg  acagcttca  1680
ggctttcgc  aaggctctg  gtgtcatgg  tgaccttaa  tcgggggtt  cgagagctg  1740
ctaccgggg  attgtcacc  tccagttcc  gggccgccg  gtccacctg  cgcccccac  1800
gacgtggga  ggctatgat  ctagctgga  ttagcacct  cctgtcctt  ctgggcccc  1860
ccttgccac  tcatgagct  aggtgggac  acagtcccc  ggctgcatc  gcctgcctg  1920
gtttccctc  taggtgcat  tatcttttt  atttttccg  gtggcattt  agtgcacaa  1980
tgataacaa  aggattatt  tcccgttct  aagggagtc  gatcagggg  actattcta  2040
ggtatgttg  ggggtatta  gcaggaaac  actgtgtgg  ggggggcac  gggcttgtt  2100
gggccagaa  tgtccacgt  ctgagcttt  tcctggagc  tgtgcagag  gtttggcaa  2160
gttcgctct  ttgaccaga  cccttctcc  tgacctggc  cttccagcc  gggcacgag  2220
cctccttct  tacctgctc  ccttccccc  gtggggact  agttatggg  gaaggggac  2280
tatttgtgg  caaaatgat  ctaaccaaa  gggcttcct  gtcagggcc  ggtggagtt  2340
gtgggtcat  ggggctcac  gcctcctgc  cttctctcc  gtctgaccc  cacttagcc  2400
ttctctcct  gcagcctag  agtttatag  tctgagatg  aaagttgaa  ggggcaagc  2460
agacctctc  tcagcccat  cccagctgt  aggagagag  tgcagggag  aaggccttg  2520
gctgggaca  cctctctct  gccttacct  agagaggga  tatgccctg  cccctcctt  2580
ctgaaaatc  gtgccctcc  tgttgctct  ggaggctcc  gctggcttg  tagaagaca  2640
aattcgatc  gcctgtccc  ttttcccct  gggtttgac  cacaggctc  tctcagcat  2700
aggtggagc  gtgaccagg  ggagcagtg  ccaggacgc  tctggccca  tgctgccca  2760
cctccccgc  cgctcccag  cgccccatg  cctcacagg  caggacgcc  tggcaggat  2820
gagaggact  ggtggattt  tgtttcttg  ctgacctca  tttcatgaa  gaaagtgga  2880
gctacagaa  tattttcta  aataaaggc  gaattgtct  aaaaaaaaa  aaaaaaa  2937



<210> 1780
<211> 445
<212> PRT
<213> Homo sapiens
<308> P26572
<400> 1780

Met Leu Lys Lys Gln Ser Ala Gly Leu Val Leu Trp Gly Ala Ile Leu 
  1               5                  10                  15
Phe Val Ala Trp Asn Ala Leu Leu Leu Leu Phe Phe Trp Thr Arg Pro 
             20                  25                  30
Ala Pro Gly Arg Pro Pro Ser Val Ser Ala Leu Asp Gly Asp Pro Ala 
         35                  40                  45
Ser Leu Thr Arg Glu Val Ile Arg Leu Ala Gln Asp Ala Glu Val Glu 
     50                  55                  60
Leu Glu Arg Gln Arg Gly Leu Leu Gln Gln Ile Gly Asp Ala Leu Ser 
 65                  70                  75                  80
Ser Gln Arg Gly Arg Val Pro Thr Ala Ala Pro Pro Ala Gln Pro Arg 
                 85                  90                  95
Val Pro Val Thr Pro Ala Pro Ala Val Ile Pro Ile Leu Val Ile Ala 
             100                105                110
Cys Asp Arg Ser Thr Val Arg Arg Cys Leu Asp Lys Leu Leu His Tyr 
         115                120                125
Arg Pro Ser Ala Glu Leu Phe Pro Ile Ile Val Ser Gln Asp Cys Gly 
     130                135                140
His Glu Glu Thr Ala Gln Ala Ile Ala Ser Tyr Gly Ser Ala Val Thr 
 145                150                155                160
His Ile Arg Gln Pro Asp Leu Ser Ser Ile Ala Val Pro Pro Asp His 
                 165                170                175
Arg Lys Phe Gln Gly Tyr Tyr Lys Ile Ala Arg His Tyr Arg Trp Ala 
             180                185                190
Leu Gly Gln Val Phe Arg Gln Phe Arg Phe Pro Ala Ala Val Val Val 
         195                200                205
Glu Asp Asp Leu Glu Val Ala Pro Asp Phe Phe Glu Tyr Phe Arg Ala 
     210                215                220
Thr Tyr Pro Leu Leu Lys Ala Asp Pro Ser Leu Trp Cys Val Ser Ala 
 225                230                235                240
Trp Asn Asp Asn Gly Lys Glu Gln Met Val Asp Ala Ser Arg Pro Glu 
                 245                250                255
Leu Leu Tyr Arg Thr Asp Phe Phe Pro Gly Leu Gly Trp Leu Leu Leu 
             260                265                270
Ala Glu Leu Trp Ala Glu Leu Glu Pro Lys Trp Pro Lys Ala Phe Trp 
         275                280                285
Asp Asp Trp Met Arg Arg Pro Glu Gln Arg Gln Gly Arg Ala Cys Ile 
     290                295                300
Arg Pro Glu Ile Ser Arg Thr Met Thr Phe Gly Arg Lys Gly Val Ser 
 305                310                315                320
His Gly Gln Phe Phe Asp Gln His Leu Lys Phe Ile Lys Leu Asn Gln 
                 325                330                335
Gln Phe Val His Phe Thr Gln Leu Asp Leu Ser Tyr Leu Gln Arg Glu 
             340                345                350
Ala Tyr Asp Arg Asp Phe Leu Ala Arg Val Tyr Gly Ala Pro Gln Leu 
         355                360                365
Gln Val Glu Lys Val Arg Thr Asn Asp Arg Lys Glu Leu Gly Glu Val 
     370                375                380
Arg Val Gln Tyr Thr Gly Arg Asp Ser Phe Lys Ala Phe Ala Lys Ala 
 385                390                395                400
Leu Gly Val Met Asp Asp Leu Lys Ser Gly Val Pro Arg Ala Gly Tyr 
                 405                410                415
Arg Gly Ile Val Thr Phe Gln Phe Arg Gly Arg Arg Val His Leu Ala 
             420                425                430
Pro Pro Pro Thr Trp Glu Gly Tyr Asp Pro Ser Trp Asn 
         435                440                445



<210> 1781
<211> 1120
<212> DNA
<213> Rattus norvegicus
<308> D16308
<400> 1781

cagcccttg  ggctcttgc  cgcccacct  ccactcttc  ctccctctc  cttttgcca  60
ttctttcct  tcccaaatc  cgcattcag  caaaggaag  aggtaaggg  agcacctcc  120
acctccaaa  aaaaataat  ataaatttt  cagtcggga  cgagtggtg  ccggctagc  180
atggagctg  tgtgctgtg  ggtggaccc  gtccgcagg  ccgtgccgg  ccgcaacct  240
ctggaagac  gcgtcctgc  gaacctgtt  actatcgag  agcgctacc  cccgcagtg  300
tcctatttc  agtgcgtgc  gaaggacat  cagccgtac  tgcgcagga  ggtggctac  360
tggatgcta  aggtctgtg  gggacagaa  tgtgaagaa  aggtctttc  tctggccat  420
aattacctg  accgtttct  ggctggagt  ccgactcct  agacccatc  ccagctcct  480
ggcgctgtg  tcatgttcc  agcttccaa  ctgaaagag  ccatcccgc  gactgccga  540
aagctgtgt  tttacaccg  caattctgt  aaaccccag  agctgctgg  gtgggaact  600
gtggtgctg  gtaagctga  gtggaacct  gctgcagta  cccctcacg  cttcattga  660
cacatccta  gcaagctgc  ccagcagaa  gagaagctg  ccctgatcc  caagcatgc  720
cagaccttc  tcgctctgt  tgctaccga  ttcaagttt  ccatgtacc  gccatcgat  780
atcgcaact  gaagcgtgg  agcagccat  tgcgggctt  agcaggacg  ggaagtgaa  840
gcactcacg  gcgatgccc  gacggagct  ctggccaag  tcacccaca  cgatgtgga  900
tgtctcaaa  cctgccagg  gcaaatcga  gctgtgctg  ttaacagcc  tcagcagtt  960
cgtcaagag  agcacaacg  ctccaagtc  gtggaagat  cggaccaag  caccacccc  1020
acagacgtg  gggatgttg  cctgtgagg  agccattcg  gcggcaaga  agaggcgtg  1080
tcgtcatct  ctagcccct  ctctctctc  ctctagttat  1120



<210> 1782
<211> 288
<212> PRT
<213> Rattus norvegicus
<308> BAA03815
<400> 1782

Met Glu Leu Leu Cys Cys Glu Val Asp Pro Val Arg Arg Ala Val Pro 
  1               5                  10                  15
Asp Arg Asn Leu Leu Glu Asp Arg Val Leu Gln Asn Leu Leu Thr Ile 
             20                  25                  30
Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln Lys 
         35                  40                  45
Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu Glu 
     50                  55                  60
Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala Met 
 65                  70                  75                  80
Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Thr His 
                 85                  90                  95
Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu Lys 
             100                105                110
Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp Asn 
         115                120                125
Ser Val Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu Gly 
     130                135                140
Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile Glu 
 145                150                155                160
His Ile Leu Arg Lys Leu Pro Gln Gln Lys Glu Lys Leu Ser Leu Ile 
                 165                170                175
Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe Lys 
             180                185                190
Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly Ala 
         195                200                205
Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Asn Ala Leu Thr Cys 
     210                215                220
Asp Ala Leu Thr Glu Leu Leu Thr Lys Ile Thr His Thr Asp Val Asp 
 225                230                235                240
Cys Leu Lys Ala Cys Gln Glu Gln Ile Glu Ala Val Leu Leu Asn Ser 
                 245                250                255
Leu Gln Gln Phe Arg Gln Glu Gln His Asn Gly Ser Lys Ser Val Glu 
             260                265                270
Asp Pro Asp Gln Ala Thr Thr Pro Thr Asp Val Arg Asp Val Asp Leu 
         275                280                285



<210> 1784
<211> 289
<212> PRT
<213> Homo sapiens
<308> P30279
<400> 1784

Met Glu Leu Leu Cys His Glu Val Asp Pro Val Arg Arg Ala Val Arg 
  1               5                  10                  15
Asp Arg Asn Leu Leu Arg Asp Asp Arg Val Leu Gln Asn Leu Leu Thr 
             20                  25                  30
Ile Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln 
         35                  40                  45
Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu 
     50                  55                  60
Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala 
 65                  70                  75                  80
Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Ser 
                 85                  90                  95
His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu 
             100                105                110
Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp 
         115                120                125
Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu 
     130                135                140
Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile 
 145                150                155                160
Glu His Ile Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu 
                 165                170                175
Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe 
             180                185                190
Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly 
         195                200                205
Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser Leu Thr 
     210                215                220
Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val 
 225                230                235                240
Asp Cys Leu Lys Ala Cys Gln Glu Gln Ile Glu Ala Val Leu Leu Asn 
                 245                250                255
Ser Leu Gln Gln Tyr Arg Gln Asp Gln Arg Asp Gly Ser Lys Ser Glu 
             260                265                270
Asp Glu Leu Asp Gln Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp 
         275                280                285
Leu 
     290



<210> 1785
<211> 1843
<212> DNA
<213> Rattus norvegicus
<308> D16309
<400> 1785

tctcactca  acgcgacgc  tcgcttctc  taggactcg  tagcccgca  tcctgctct  60
acccgtgag  catagcagg  tggagctgc  gtgttgcga  ggcacccgg  tcgcgcccc  120
ggccgggcc  gacccgcgg  tactggggg  ccagcgtgt  ctgcagagt  tgctccgct  180
ggaggagcg  tacgtgccg  gaggctcct  cttccagtg  gtgcaaaag  agatcaagc  240
gcacatgcg  aagatgctg  cgtactgga  gctggaggt  tgtgaggag  agcgctgcg  300
ggaggatgt  ttccctctg  ctatgaact  cctggatcg  tacctgtcc  gcgtcccca  360
ccgaaaggc  caactgcag  ttctaggta  cgtctgcct  ttgctggcc  ccaagctgc  420
cgaaaccac  cccctgact  ttgagaagc  ctgcatcta  acggaccaa  ctatggctc  480
ctggcagtt  cgggaatgg  aggtgctgg  cctggggaa  ctcaagtgg  acctggctg  540
tgtgattgc  cacgacttc  tggccttga  tctgcaccg  ctctctctg  ccagtgacc  600
gcaggcact  gtcaaaaag  atgctcaga  ctttttggc  ctctgtgcc  cagattaca  660
ctttgcgat  taccctcca  ccatgatcg  cacgggcag  atcggggct  cagtgctag  720
cctgggtgc  tgctctatg  ctgcagatg  gctcacaga  ctgctggcg  gaatcacag  780
cactgaagt  gactgcctg  gtgcctgcc  ggagcagca  atcgaagct  ccctcaggg  840
gagcctcag  gaagctgct  agacagccc  cagccccgt  cccaaagcc  ccggggggt  900
tagcagcca  gggcccagt  agaccagca  tcccacaga  gtcacagcc  tccacctgt  960
gtttgggac  ggccccctc  ggtggccac  aagcagagg  ggggcccct  ccaccccct  1020
cctccctct  ggaacaatt  atgccatat  tgaagcccg  gggggctct  tttcccctc  1080
caaagccca  ggggccagg  cctgcctat  cccacagtg  gcactaagg  gctgcttgg  1140
catgagggt  tctacatgg  cagtcagtt  ctcttcctt  ccactcaac  agcttggct  1200
tcctgggcc  tgatggtca  agagataca  acaggtaga  cccacacac  agcatttct  1260
ttgagtccc  cctctgtct  gggcgccga  cctttcagt  gccaaaacg  cccagtacc  1320
tccaaaggt  ttgttgccc  tcgcagggt  actgcattt  gatctgggt  cttcagaaa  1380
cccgataga  gcctatgag  agccaacct  gatggctgc  gtgtaatcc  tactccagc  1440
gctcttagc  ggaaccagc  taggccttg  ctagaagag  aagcgcccg  aaactgttg  1500
tttgcttcc  gctatgctt  tgtggttga  ggtcttgag  gtgctgatg  tcattttaa  1560
ttattgctt  gaatacacc  taagagggt  cagtgaggc  tgtacccca  aagtggtgg  1620
aaccctggc  gttgctctt  ccctcccct  tgctaccgc  ttgtggccc  ggagctgct  1680
cagcctggg  gggggtcct  ccttcctct  cgtagccct  cagctcatc  tcagcgggg  1740
gggtttaat  gggatggat  ccgtggagg  gactggact  tccggagag  gggcgagcc  1800
catggacac  ggtgtttcc  caggccaca  ggtttgggg  gcc  1843



<210> 1786
<211> 293
<212> PRT
<213> Rattus norvegicus
<308> BAA03816
<400> 1786

Met Glu Leu Leu Cys Cys Glu Gly Thr Arg Leu Ala Pro Arg Ala Gly 
  1               5                  10                  15
Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu 
             20                  25                  30
Arg Leu Glu Glu Arg Tyr Val Pro Arg Gly Ser Tyr Phe Gln Cys Val 
         35                  40                  45
Gln Lys Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Arg Cys Glu Glu Asp Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Thr Arg Lys 
                 85                  90                  95
Ala Gln Leu Gln Leu Leu Gly Thr Val Cys Leu Leu Leu Ala Ser Lys 
             100                105                110
Leu Arg Glu Thr Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Gln Ala Met Ala Pro Trp Gln Leu Arg Glu Trp Glu Val Leu Val 
     130                135                140
Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 
 145                150                155                160
Leu Ala Leu Ile Leu His Arg Leu Ser Leu Pro Ser Asp Arg Gln Ala 
                 165                170                175
Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu Cys Ala Thr Asp 
             180                185                190
Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Ile 
         195                200                205
Gly Ala Ala Val Leu Gly Leu Gly Ala Cys Ser Met Ser Ala Asp Glu 
     210                215                220
Leu Thr Glu Leu Leu Ala Gly Ile Thr Gly Thr Glu Val Asp Cys Leu 
 225                230                235                240
Arg Ala Cys Gln Glu Gln Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu 
                 245                250                255
Arg Glu Ala Ala Gln Thr Ala Pro Ser Pro Val Pro Lys Ala Pro Gly 
             260                265                270
Gly Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val 
         275                280                285
Thr Ala Ile His Leu 
     290



<210> 1787
<211> 2095
<212> DNA
<213> Homo sapiens
<308> NM_001760
<400> 1787

gcgcctgtc  gggaagcgg  gcgcgcgcg  gggcggcgg  cgggctggg  atccgccgc  60
cagtgccag  gccagcgcc  gacccgcgc  ccgcgctct  cggcccgtc  cctgccttg  120
gactcgcga  cccgcactc  cgccctgcc  gttcgctgc  cgagtatgg  gctgctgtg  180
tgcgaaggc  cccggcacg  gccccgggc  gggccggac  cgcggctgc  gggggacca  240
cgtgtcctg  agagcctgc  ccgcctgga  gagcgctac  taccccgcg  ctcctactt  300
cagtgcgtg  agcgggaga  caagccgca  atgcggaag  tgctggctt  ctggatgct  360
gaggtatgt  aggagcagc  ctgtgagga  gaagtcttc  ccctggcca  gaactacct  420
gatcgctac  tgtcttgcg  ccccacccg  aaggcgcag  tgcagctcc  gggtgcggt  480
tgcatgctg  tggcctcca  gctgcgcga  accacgccc  tgaccatcg  aaaactgtg  540
atctacacc  accacgctg  ctctccccg  cagttgcgg  actgggagg  gctggtcct  600
gggaagctc  agtgggacc  ggctgctgt  attgcacat  atttcctgg  cttcattct  660
caccggctc  ctctgcccc  tgaccgaca  gccttggtc  aaaagcatg  ccagacctt  720
ttggccctc  gtgctacag  ttatacctt  gccatgtac  cgccatcca  gatcgccac  780
ggcagcatt  gggctgcag  gcaaggcct  ggtgcctgc  ccatgtccg  ggatgagct  840
acagagctg  tggcaggga  cactggcac  gaagtggac  gcctgcggg  ctgtcagga  900
cagatcgaa  ctgcactca  ggagagcct  agggaagcc  ctcagacca  ctccagccc  960
gcgcccaaa  ccccccggg  ctccagcag  caagggccc  gccagacca  cactcctac  1020
gatgtcaca  ccatacacc  gtagccctg  agaggccct  tggagtggc  actaagcag  1080
ggaggggcc  ctgccaccc  cctccctgc  tccaggaac  acaccacat  taagcctga  1140
ggggcgtct  ttccccctt  acaaagccc  agggatctg  tcctaccca  ccccgcagt  1200
tgcactaag  ggcccggcc  gccatgtct  catttcggt  gctagtcaa  ctcctcctc  1260
ctgcatctg  ccagcagcg  ctttcccaa  tctagctgg  ggtgggcca  gctgatggg  1320
cagaattgg  tacatacac  agcattcct  ttgaacgcc  ccccccacc  ctgggggct  1380
tcatgtttt  aactgccaa  atgctctag  gccttctaa  ggtgttgtc  cttctaggg  1440
tattgcatt  ggattgggg  ccctctaaa  tttaatgca  gatagacac  tatgagggg  1500
aatagtcta  atggctcct  tcagtactt  ggaggcccc  atgtagtcc  tgctgacag  1560
tgctcctag  gggaggggc  taggcctca  ccagagaag  tataaattc  tctttgctt  1620
gctttctgc  cagcttctc  tgtgtgatt  acagctttg  tgctgaagg  tcattttaa  1680
ttattaatt  ctttgagca  aactttaag  ggacataat  ggggcctgg  catcccaca  1740
gtggtggta  ccctggtgg  tgctgtttt  ctcccttct  ctactggca  aaggatctt  1800
gtggccaag  agctgctat  gcctggggt  gggtcatgc  ctcctctcc  attgtccct  1860
tgccccatc  tccagcagg  aaaatgcag  agggatgcc  tggaggtgg  tgagcccct  1920
tctagagag  gaggcaagc  ctgttgaca  aggtctttc  taaggctgc  aggtttagg  1980
tggtggccc  ggaccatca  cctactgta  taaagatga  tgtgaaata  aactggctt  2040
ggcttcttg  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  2095



<210> 1788
<211> 292
<212> PRT
<213> Homo sapiens
<308> P30281
<400> 1788

Met Glu Leu Leu Cys Cys Glu Gly Thr Arg His Ala Pro Arg Ala Gly 
  1               5                  10                  15
Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu 
             20                  25                  30
Arg Leu Glu Glu Arg Tyr Val Pro Arg Ala Ser Tyr Phe Gln Cys Val 
         35                  40                  45
Gln Arg Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Arg Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Thr Arg Lys 
                 85                  90                  95
Ala Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys 
             100                105                110
Leu Arg Glu Thr Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp His Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val 
     130                135                140
Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 
 145                150                155                160
Leu Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala 
                 165                170                175
Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu Cys Ala Thr Asp 
             180                185                190
Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Ile 
         195                200                205
Gly Ala Ala Val Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu 
     210                215                220
Leu Thr Glu Leu Leu Ala Gly Ile Thr Gly Thr Glu Val Asp Cys Leu 
 225                230                235                240
Arg Ala Cys Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg 
                 245                250                255
Glu Ala Ser Gln Thr Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly 
             260                265                270
Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val Thr 
         275                280                285
Ala Ile His Leu 
     290



<210> 1789
<211> 1843
<212> DNA
<213> Rattus norvegicus
<308> D16309
<400> 1789

tctcactca  acgcgacgc  tcgcttctc  taggactcg  tagcccgca  tcctgctct  60
acccgtgag  catagcagg  tggagctgc  gtgttgcga  ggcacccgg  tcgcgcccc  120
ggccgggcc  gacccgcgg  tactggggg  ccagcgtgt  ctgcagagt  tgctccgct  180
ggaggagcg  tacgtgccg  gaggctcct  cttccagtg  gtgcaaaag  agatcaagc  240
gcacatgcg  aagatgctg  cgtactgga  gctggaggt  tgtgaggag  agcgctgcg  300
ggaggatgt  ttccctctg  ctatgaact  cctggatcg  tacctgtcc  gcgtcccca  360
ccgaaaggc  caactgcag  ttctaggta  cgtctgcct  ttgctggcc  ccaagctgc  420
cgaaaccac  cccctgact  ttgagaagc  ctgcatcta  acggaccaa  ctatggctc  480
ctggcagtt  cgggaatgg  aggtgctgg  cctggggaa  ctcaagtgg  acctggctg  540
tgtgattgc  cacgacttc  tggccttga  tctgcaccg  ctctctctg  ccagtgacc  600
gcaggcact  gtcaaaaag  atgctcaga  ctttttggc  ctctgtgcc  cagattaca  660
ctttgcgat  taccctcca  ccatgatcg  cacgggcag  atcggggct  cagtgctag  720
cctgggtgc  tgctctatg  ctgcagatg  gctcacaga  ctgctggcg  gaatcacag  780
cactgaagt  gactgcctg  gtgcctgcc  ggagcagca  atcgaagct  ccctcaggg  840
gagcctcag  gaagctgct  agacagccc  cagccccgt  cccaaagcc  ccggggggt  900
tagcagcca  gggcccagt  agaccagca  tcccacaga  gtcacagcc  tccacctgt  960
gtttgggac  ggccccctc  ggtggccac  aagcagagg  ggggcccct  ccaccccct  1020
cctccctct  ggaacaatt  atgccatat  tgaagcccg  gggggctct  tttcccctc  1080
caaagccca  ggggccagg  cctgcctat  cccacagtg  gcactaagg  gctgcttgg  1140
catgagggt  tctacatgg  cagtcagtt  ctcttcctt  ccactcaac  agcttggct  1200
tcctgggcc  tgatggtca  agagataca  acaggtaga  cccacacac  agcatttct  1260
ttgagtccc  cctctgtct  gggcgccga  cctttcagt  gccaaaacg  cccagtacc  1320
tccaaaggt  ttgttgccc  tcgcagggt  actgcattt  gatctgggt  cttcagaaa  1380
cccgataga  gcctatgag  agccaacct  gatggctgc  gtgtaatcc  tactccagc  1440
gctcttagc  ggaaccagc  taggccttg  ctagaagag  aagcgcccg  aaactgttg  1500
tttgcttcc  gctatgctt  tgtggttga  ggtcttgag  gtgctgatg  tcattttaa  1560
ttattgctt  gaatacacc  taagagggt  cagtgaggc  tgtacccca  aagtggtgg  1620
aaccctggc  gttgctctt  ccctcccct  tgctaccgc  ttgtggccc  ggagctgct  1680
cagcctggg  gggggtcct  ccttcctct  cgtagccct  cagctcatc  tcagcgggg  1740
gggtttaat  gggatggat  ccgtggagg  gactggact  tccggagag  gggcgagcc  1800
catggacac  ggtgtttcc  caggccaca  ggtttgggg  gcc  1843



<210> 1790
<211> 293
<212> PRT
<213> Rattus norvegicus
<308> BAA03816
<400> 1790

Met Glu Leu Leu Cys Cys Glu Gly Thr Arg Leu Ala Pro Arg Ala Gly 
  1               5                  10                  15
Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu 
             20                  25                  30
Arg Leu Glu Glu Arg Tyr Val Pro Arg Gly Ser Tyr Phe Gln Cys Val 
         35                  40                  45
Gln Lys Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Arg Cys Glu Glu Asp Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Thr Arg Lys 
                 85                  90                  95
Ala Gln Leu Gln Leu Leu Gly Thr Val Cys Leu Leu Leu Ala Ser Lys 
             100                105                110
Leu Arg Glu Thr Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Gln Ala Met Ala Pro Trp Gln Leu Arg Glu Trp Glu Val Leu Val 
     130                135                140
Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 
 145                150                155                160
Leu Ala Leu Ile Leu His Arg Leu Ser Leu Pro Ser Asp Arg Gln Ala 
                 165                170                175
Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu Cys Ala Thr Asp 
             180                185                190
Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Ile 
         195                200                205
Gly Ala Ala Val Leu Gly Leu Gly Ala Cys Ser Met Ser Ala Asp Glu 
     210                215                220
Leu Thr Glu Leu Leu Ala Gly Ile Thr Gly Thr Glu Val Asp Cys Leu 
 225                230                235                240
Arg Ala Cys Gln Glu Gln Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu 
                 245                250                255
Arg Glu Ala Ala Gln Thr Ala Pro Ser Pro Val Pro Lys Ala Pro Gly 
             260                265                270
Gly Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val 
         275                280                285
Thr Ala Ile His Leu 
     290



<210> 1791
<211> 2095
<212> DNA
<213> Homo sapiens
<308> NM_001760
<400> 1791

gcgcctgtc  gggaagcgg  gcgcgcgcg  gggcggcgg  cgggctggg  atccgccgc  60
cagtgccag  gccagcgcc  gacccgcgc  ccgcgctct  cggcccgtc  cctgccttg  120
gactcgcga  cccgcactc  cgccctgcc  gttcgctgc  cgagtatgg  gctgctgtg  180
tgcgaaggc  cccggcacg  gccccgggc  gggccggac  cgcggctgc  gggggacca  240
cgtgtcctg  agagcctgc  ccgcctgga  gagcgctac  taccccgcg  ctcctactt  300
cagtgcgtg  agcgggaga  caagccgca  atgcggaag  tgctggctt  ctggatgct  360
gaggtatgt  aggagcagc  ctgtgagga  gaagtcttc  ccctggcca  gaactacct  420
gatcgctac  tgtcttgcg  ccccacccg  aaggcgcag  tgcagctcc  gggtgcggt  480
tgcatgctg  tggcctcca  gctgcgcga  accacgccc  tgaccatcg  aaaactgtg  540
atctacacc  accacgctg  ctctccccg  cagttgcgg  actgggagg  gctggtcct  600
gggaagctc  agtgggacc  ggctgctgt  attgcacat  atttcctgg  cttcattct  660
caccggctc  ctctgcccc  tgaccgaca  gccttggtc  aaaagcatg  ccagacctt  720
ttggccctc  gtgctacag  ttatacctt  gccatgtac  cgccatcca  gatcgccac  780
ggcagcatt  gggctgcag  gcaaggcct  ggtgcctgc  ccatgtccg  ggatgagct  840
acagagctg  tggcaggga  cactggcac  gaagtggac  gcctgcggg  ctgtcagga  900
cagatcgaa  ctgcactca  ggagagcct  agggaagcc  ctcagacca  ctccagccc  960
gcgcccaaa  ccccccggg  ctccagcag  caagggccc  gccagacca  cactcctac  1020
gatgtcaca  ccatacacc  gtagccctg  agaggccct  tggagtggc  actaagcag  1080
ggaggggcc  ctgccaccc  cctccctgc  tccaggaac  acaccacat  taagcctga  1140
ggggcgtct  ttccccctt  acaaagccc  agggatctg  tcctaccca  ccccgcagt  1200
tgcactaag  ggcccggcc  gccatgtct  catttcggt  gctagtcaa  ctcctcctc  1260
ctgcatctg  ccagcagcg  ctttcccaa  tctagctgg  ggtgggcca  gctgatggg  1320
cagaattgg  tacatacac  agcattcct  ttgaacgcc  ccccccacc  ctgggggct  1380
tcatgtttt  aactgccaa  atgctctag  gccttctaa  ggtgttgtc  cttctaggg  1440
tattgcatt  ggattgggg  ccctctaaa  tttaatgca  gatagacac  tatgagggg  1500
aatagtcta  atggctcct  tcagtactt  ggaggcccc  atgtagtcc  tgctgacag  1560
tgctcctag  gggaggggc  taggcctca  ccagagaag  tataaattc  tctttgctt  1620
gctttctgc  cagcttctc  tgtgtgatt  acagctttg  tgctgaagg  tcattttaa  1680
ttattaatt  ctttgagca  aactttaag  ggacataat  ggggcctgg  catcccaca  1740
gtggtggta  ccctggtgg  tgctgtttt  ctcccttct  ctactggca  aaggatctt  1800
gtggccaag  agctgctat  gcctggggt  gggtcatgc  ctcctctcc  attgtccct  1860
tgccccatc  tccagcagg  aaaatgcag  agggatgcc  tggaggtgg  tgagcccct  1920
tctagagag  gaggcaagc  ctgttgaca  aggtctttc  taaggctgc  aggtttagg  1980
tggtggccc  ggaccatca  cctactgta  taaagatga  tgtgaaata  aactggctt  2040
ggcttcttg  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  2095



<210> 1792
<211> 292
<212> PRT
<213> Homo sapiens
<308> P30281
<400> 1792

Met Glu Leu Leu Cys Cys Glu Gly Thr Arg His Ala Pro Arg Ala Gly 
  1               5                  10                  15
Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu 
             20                  25                  30
Arg Leu Glu Glu Arg Tyr Val Pro Arg Ala Ser Tyr Phe Gln Cys Val 
         35                  40                  45
Gln Arg Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Arg Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Thr Arg Lys 
                 85                  90                  95
Ala Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys 
             100                105                110
Leu Arg Glu Thr Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp His Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val 
     130                135                140
Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 
 145                150                155                160
Leu Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala 
                 165                170                175
Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu Cys Ala Thr Asp 
             180                185                190
Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Ile 
         195                200                205
Gly Ala Ala Val Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu 
     210                215                220
Leu Thr Glu Leu Leu Ala Gly Ile Thr Gly Thr Glu Val Asp Cys Leu 
 225                230                235                240
Arg Ala Cys Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg 
                 245                250                255
Glu Ala Ser Gln Thr Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly 
             260                265                270
Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val Thr 
         275                280                285
Ala Ile His Leu 
     290



<210> 1793
<211> 1843
<212> DNA
<213> Rattus norvegicus
<308> D16309
<400> 1793

tctcactca  acgcgacgc  tcgcttctc  taggactcg  tagcccgca  tcctgctct  60
acccgtgag  catagcagg  tggagctgc  gtgttgcga  ggcacccgg  tcgcgcccc  120
ggccgggcc  gacccgcgg  tactggggg  ccagcgtgt  ctgcagagt  tgctccgct  180
ggaggagcg  tacgtgccg  gaggctcct  cttccagtg  gtgcaaaag  agatcaagc  240
gcacatgcg  aagatgctg  cgtactgga  gctggaggt  tgtgaggag  agcgctgcg  300
ggaggatgt  ttccctctg  ctatgaact  cctggatcg  tacctgtcc  gcgtcccca  360
ccgaaaggc  caactgcag  ttctaggta  cgtctgcct  ttgctggcc  ccaagctgc  420
cgaaaccac  cccctgact  ttgagaagc  ctgcatcta  acggaccaa  ctatggctc  480
ctggcagtt  cgggaatgg  aggtgctgg  cctggggaa  ctcaagtgg  acctggctg  540
tgtgattgc  cacgacttc  tggccttga  tctgcaccg  ctctctctg  ccagtgacc  600
gcaggcact  gtcaaaaag  atgctcaga  ctttttggc  ctctgtgcc  cagattaca  660
ctttgcgat  taccctcca  ccatgatcg  cacgggcag  atcggggct  cagtgctag  720
cctgggtgc  tgctctatg  ctgcagatg  gctcacaga  ctgctggcg  gaatcacag  780
cactgaagt  gactgcctg  gtgcctgcc  ggagcagca  atcgaagct  ccctcaggg  840
gagcctcag  gaagctgct  agacagccc  cagccccgt  cccaaagcc  ccggggggt  900
tagcagcca  gggcccagt  agaccagca  tcccacaga  gtcacagcc  tccacctgt  960
gtttgggac  ggccccctc  ggtggccac  aagcagagg  ggggcccct  ccaccccct  1020
cctccctct  ggaacaatt  atgccatat  tgaagcccg  gggggctct  tttcccctc  1080
caaagccca  ggggccagg  cctgcctat  cccacagtg  gcactaagg  gctgcttgg  1140
catgagggt  tctacatgg  cagtcagtt  ctcttcctt  ccactcaac  agcttggct  1200
tcctgggcc  tgatggtca  agagataca  acaggtaga  cccacacac  agcatttct  1260
ttgagtccc  cctctgtct  gggcgccga  cctttcagt  gccaaaacg  cccagtacc  1320
tccaaaggt  ttgttgccc  tcgcagggt  actgcattt  gatctgggt  cttcagaaa  1380
cccgataga  gcctatgag  agccaacct  gatggctgc  gtgtaatcc  tactccagc  1440
gctcttagc  ggaaccagc  taggccttg  ctagaagag  aagcgcccg  aaactgttg  1500
tttgcttcc  gctatgctt  tgtggttga  ggtcttgag  gtgctgatg  tcattttaa  1560
ttattgctt  gaatacacc  taagagggt  cagtgaggc  tgtacccca  aagtggtgg  1620
aaccctggc  gttgctctt  ccctcccct  tgctaccgc  ttgtggccc  ggagctgct  1680
cagcctggg  gggggtcct  ccttcctct  cgtagccct  cagctcatc  tcagcgggg  1740
gggtttaat  gggatggat  ccgtggagg  gactggact  tccggagag  gggcgagcc  1800
catggacac  ggtgtttcc  caggccaca  ggtttgggg  gcc  1843



<210> 1794
<211> 293
<212> PRT
<213> Rattus norvegicus
<308> BAA03816
<400> 1794

Met Glu Leu Leu Cys Cys Glu Gly Thr Arg Leu Ala Pro Arg Ala Gly 
  1               5                  10                  15
Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu 
             20                  25                  30
Arg Leu Glu Glu Arg Tyr Val Pro Arg Gly Ser Tyr Phe Gln Cys Val 
         35                  40                  45
Gln Lys Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Arg Cys Glu Glu Asp Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Thr Arg Lys 
                 85                  90                  95
Ala Gln Leu Gln Leu Leu Gly Thr Val Cys Leu Leu Leu Ala Ser Lys 
             100                105                110
Leu Arg Glu Thr Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Gln Ala Met Ala Pro Trp Gln Leu Arg Glu Trp Glu Val Leu Val 
     130                135                140
Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 
 145                150                155                160
Leu Ala Leu Ile Leu His Arg Leu Ser Leu Pro Ser Asp Arg Gln Ala 
                 165                170                175
Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu Cys Ala Thr Asp 
             180                185                190
Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Ile 
         195                200                205
Gly Ala Ala Val Leu Gly Leu Gly Ala Cys Ser Met Ser Ala Asp Glu 
     210                215                220
Leu Thr Glu Leu Leu Ala Gly Ile Thr Gly Thr Glu Val Asp Cys Leu 
 225                230                235                240
Arg Ala Cys Gln Glu Gln Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu 
                 245                250                255
Arg Glu Ala Ala Gln Thr Ala Pro Ser Pro Val Pro Lys Ala Pro Gly 
             260                265                270
Gly Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val 
         275                280                285
Thr Ala Ile His Leu 
     290



<210> 1795
<211> 2095
<212> DNA
<213> Homo sapiens
<308> NM_001760
<400> 1795

gcgcctgtc  gggaagcgg  gcgcgcgcg  gggcggcgg  cgggctggg  atccgccgc  60
cagtgccag  gccagcgcc  gacccgcgc  ccgcgctct  cggcccgtc  cctgccttg  120
gactcgcga  cccgcactc  cgccctgcc  gttcgctgc  cgagtatgg  gctgctgtg  180
tgcgaaggc  cccggcacg  gccccgggc  gggccggac  cgcggctgc  gggggacca  240
cgtgtcctg  agagcctgc  ccgcctgga  gagcgctac  taccccgcg  ctcctactt  300
cagtgcgtg  agcgggaga  caagccgca  atgcggaag  tgctggctt  ctggatgct  360
gaggtatgt  aggagcagc  ctgtgagga  gaagtcttc  ccctggcca  gaactacct  420
gatcgctac  tgtcttgcg  ccccacccg  aaggcgcag  tgcagctcc  gggtgcggt  480
tgcatgctg  tggcctcca  gctgcgcga  accacgccc  tgaccatcg  aaaactgtg  540
atctacacc  accacgctg  ctctccccg  cagttgcgg  actgggagg  gctggtcct  600
gggaagctc  agtgggacc  ggctgctgt  attgcacat  atttcctgg  cttcattct  660
caccggctc  ctctgcccc  tgaccgaca  gccttggtc  aaaagcatg  ccagacctt  720
ttggccctc  gtgctacag  ttatacctt  gccatgtac  cgccatcca  gatcgccac  780
ggcagcatt  gggctgcag  gcaaggcct  ggtgcctgc  ccatgtccg  ggatgagct  840
acagagctg  tggcaggga  cactggcac  gaagtggac  gcctgcggg  ctgtcagga  900
cagatcgaa  ctgcactca  ggagagcct  agggaagcc  ctcagacca  ctccagccc  960
gcgcccaaa  ccccccggg  ctccagcag  caagggccc  gccagacca  cactcctac  1020
gatgtcaca  ccatacacc  gtagccctg  agaggccct  tggagtggc  actaagcag  1080
ggaggggcc  ctgccaccc  cctccctgc  tccaggaac  acaccacat  taagcctga  1140
ggggcgtct  ttccccctt  acaaagccc  agggatctg  tcctaccca  ccccgcagt  1200
tgcactaag  ggcccggcc  gccatgtct  catttcggt  gctagtcaa  ctcctcctc  1260
ctgcatctg  ccagcagcg  ctttcccaa  tctagctgg  ggtgggcca  gctgatggg  1320
cagaattgg  tacatacac  agcattcct  ttgaacgcc  ccccccacc  ctgggggct  1380
tcatgtttt  aactgccaa  atgctctag  gccttctaa  ggtgttgtc  cttctaggg  1440
tattgcatt  ggattgggg  ccctctaaa  tttaatgca  gatagacac  tatgagggg  1500
aatagtcta  atggctcct  tcagtactt  ggaggcccc  atgtagtcc  tgctgacag  1560
tgctcctag  gggaggggc  taggcctca  ccagagaag  tataaattc  tctttgctt  1620
gctttctgc  cagcttctc  tgtgtgatt  acagctttg  tgctgaagg  tcattttaa  1680
ttattaatt  ctttgagca  aactttaag  ggacataat  ggggcctgg  catcccaca  1740
gtggtggta  ccctggtgg  tgctgtttt  ctcccttct  ctactggca  aaggatctt  1800
gtggccaag  agctgctat  gcctggggt  gggtcatgc  ctcctctcc  attgtccct  1860
tgccccatc  tccagcagg  aaaatgcag  agggatgcc  tggaggtgg  tgagcccct  1920
tctagagag  gaggcaagc  ctgttgaca  aggtctttc  taaggctgc  aggtttagg  1980
tggtggccc  ggaccatca  cctactgta  taaagatga  tgtgaaata  aactggctt  2040
ggcttcttg  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  2095



<210> 1796
<211> 292
<212> PRT
<213> Homo sapiens
<308> P30281
<400> 1796

Met Glu Leu Leu Cys Cys Glu Gly Thr Arg His Ala Pro Arg Ala Gly 
  1               5                  10                  15
Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu 
             20                  25                  30
Arg Leu Glu Glu Arg Tyr Val Pro Arg Ala Ser Tyr Phe Gln Cys Val 
         35                  40                  45
Gln Arg Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Arg Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Thr Arg Lys 
                 85                  90                  95
Ala Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys 
             100                105                110
Leu Arg Glu Thr Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp His Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val 
     130                135                140
Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 
 145                150                155                160
Leu Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala 
                 165                170                175
Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu Cys Ala Thr Asp 
             180                185                190
Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Ile 
         195                200                205
Gly Ala Ala Val Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu 
     210                215                220
Leu Thr Glu Leu Leu Ala Gly Ile Thr Gly Thr Glu Val Asp Cys Leu 
 225                230                235                240
Arg Ala Cys Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg 
                 245                250                255
Glu Ala Ser Gln Thr Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly 
             260                265                270
Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val Thr 
         275                280                285
Ala Ile His Leu 
     290



<210> 1797
<211> 1843
<212> DNA
<213> Rattus norvegicus
<308> D16309
<400> 1797

tctcactca  acgcgacgc  tcgcttctc  taggactcg  tagcccgca  tcctgctct  60
acccgtgag  catagcagg  tggagctgc  gtgttgcga  ggcacccgg  tcgcgcccc  120
ggccgggcc  gacccgcgg  tactggggg  ccagcgtgt  ctgcagagt  tgctccgct  180
ggaggagcg  tacgtgccg  gaggctcct  cttccagtg  gtgcaaaag  agatcaagc  240
gcacatgcg  aagatgctg  cgtactgga  gctggaggt  tgtgaggag  agcgctgcg  300
ggaggatgt  ttccctctg  ctatgaact  cctggatcg  tacctgtcc  gcgtcccca  360
ccgaaaggc  caactgcag  ttctaggta  cgtctgcct  ttgctggcc  ccaagctgc  420
cgaaaccac  cccctgact  ttgagaagc  ctgcatcta  acggaccaa  ctatggctc  480
ctggcagtt  cgggaatgg  aggtgctgg  cctggggaa  ctcaagtgg  acctggctg  540
tgtgattgc  cacgacttc  tggccttga  tctgcaccg  ctctctctg  ccagtgacc  600
gcaggcact  gtcaaaaag  atgctcaga  ctttttggc  ctctgtgcc  cagattaca  660
ctttgcgat  taccctcca  ccatgatcg  cacgggcag  atcggggct  cagtgctag  720
cctgggtgc  tgctctatg  ctgcagatg  gctcacaga  ctgctggcg  gaatcacag  780
cactgaagt  gactgcctg  gtgcctgcc  ggagcagca  atcgaagct  ccctcaggg  840
gagcctcag  gaagctgct  agacagccc  cagccccgt  cccaaagcc  ccggggggt  900
tagcagcca  gggcccagt  agaccagca  tcccacaga  gtcacagcc  tccacctgt  960
gtttgggac  ggccccctc  ggtggccac  aagcagagg  ggggcccct  ccaccccct  1020
cctccctct  ggaacaatt  atgccatat  tgaagcccg  gggggctct  tttcccctc  1080
caaagccca  ggggccagg  cctgcctat  cccacagtg  gcactaagg  gctgcttgg  1140
catgagggt  tctacatgg  cagtcagtt  ctcttcctt  ccactcaac  agcttggct  1200
tcctgggcc  tgatggtca  agagataca  acaggtaga  cccacacac  agcatttct  1260
ttgagtccc  cctctgtct  gggcgccga  cctttcagt  gccaaaacg  cccagtacc  1320
tccaaaggt  ttgttgccc  tcgcagggt  actgcattt  gatctgggt  cttcagaaa  1380
cccgataga  gcctatgag  agccaacct  gatggctgc  gtgtaatcc  tactccagc  1440
gctcttagc  ggaaccagc  taggccttg  ctagaagag  aagcgcccg  aaactgttg  1500
tttgcttcc  gctatgctt  tgtggttga  ggtcttgag  gtgctgatg  tcattttaa  1560
ttattgctt  gaatacacc  taagagggt  cagtgaggc  tgtacccca  aagtggtgg  1620
aaccctggc  gttgctctt  ccctcccct  tgctaccgc  ttgtggccc  ggagctgct  1680
cagcctggg  gggggtcct  ccttcctct  cgtagccct  cagctcatc  tcagcgggg  1740
gggtttaat  gggatggat  ccgtggagg  gactggact  tccggagag  gggcgagcc  1800
catggacac  ggtgtttcc  caggccaca  ggtttgggg  gcc  1843



<210> 1798
<211> 293
<212> PRT
<213> Rattus norvegicus
<308> BAA03816
<400> 1798

Met Glu Leu Leu Cys Cys Glu Gly Thr Arg Leu Ala Pro Arg Ala Gly 
  1               5                  10                  15
Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu 
             20                  25                  30
Arg Leu Glu Glu Arg Tyr Val Pro Arg Gly Ser Tyr Phe Gln Cys Val 
         35                  40                  45
Gln Lys Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Arg Cys Glu Glu Asp Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Thr Arg Lys 
                 85                  90                  95
Ala Gln Leu Gln Leu Leu Gly Thr Val Cys Leu Leu Leu Ala Ser Lys 
             100                105                110
Leu Arg Glu Thr Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Gln Ala Met Ala Pro Trp Gln Leu Arg Glu Trp Glu Val Leu Val 
     130                135                140
Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 
 145                150                155                160
Leu Ala Leu Ile Leu His Arg Leu Ser Leu Pro Ser Asp Arg Gln Ala 
                 165                170                175
Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu Cys Ala Thr Asp 
             180                185                190
Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Ile 
         195                200                205
Gly Ala Ala Val Leu Gly Leu Gly Ala Cys Ser Met Ser Ala Asp Glu 
     210                215                220
Leu Thr Glu Leu Leu Ala Gly Ile Thr Gly Thr Glu Val Asp Cys Leu 
 225                230                235                240
Arg Ala Cys Gln Glu Gln Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu 
                 245                250                255
Arg Glu Ala Ala Gln Thr Ala Pro Ser Pro Val Pro Lys Ala Pro Gly 
             260                265                270
Gly Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val 
         275                280                285
Thr Ala Ile His Leu 
     290



<210> 1799
<211> 2095
<212> DNA
<213> Homo sapiens
<308> NM_001760
<400> 1799

gcgcctgtc  gggaagcgg  gcgcgcgcg  gggcggcgg  cgggctggg  atccgccgc  60
cagtgccag  gccagcgcc  gacccgcgc  ccgcgctct  cggcccgtc  cctgccttg  120
gactcgcga  cccgcactc  cgccctgcc  gttcgctgc  cgagtatgg  gctgctgtg  180
tgcgaaggc  cccggcacg  gccccgggc  gggccggac  cgcggctgc  gggggacca  240
cgtgtcctg  agagcctgc  ccgcctgga  gagcgctac  taccccgcg  ctcctactt  300
cagtgcgtg  agcgggaga  caagccgca  atgcggaag  tgctggctt  ctggatgct  360
gaggtatgt  aggagcagc  ctgtgagga  gaagtcttc  ccctggcca  gaactacct  420
gatcgctac  tgtcttgcg  ccccacccg  aaggcgcag  tgcagctcc  gggtgcggt  480
tgcatgctg  tggcctcca  gctgcgcga  accacgccc  tgaccatcg  aaaactgtg  540
atctacacc  accacgctg  ctctccccg  cagttgcgg  actgggagg  gctggtcct  600
gggaagctc  agtgggacc  ggctgctgt  attgcacat  atttcctgg  cttcattct  660
caccggctc  ctctgcccc  tgaccgaca  gccttggtc  aaaagcatg  ccagacctt  720
ttggccctc  gtgctacag  ttatacctt  gccatgtac  cgccatcca  gatcgccac  780
ggcagcatt  gggctgcag  gcaaggcct  ggtgcctgc  ccatgtccg  ggatgagct  840
acagagctg  tggcaggga  cactggcac  gaagtggac  gcctgcggg  ctgtcagga  900
cagatcgaa  ctgcactca  ggagagcct  agggaagcc  ctcagacca  ctccagccc  960
gcgcccaaa  ccccccggg  ctccagcag  caagggccc  gccagacca  cactcctac  1020
gatgtcaca  ccatacacc  gtagccctg  agaggccct  tggagtggc  actaagcag  1080
ggaggggcc  ctgccaccc  cctccctgc  tccaggaac  acaccacat  taagcctga  1140
ggggcgtct  ttccccctt  acaaagccc  agggatctg  tcctaccca  ccccgcagt  1200
tgcactaag  ggcccggcc  gccatgtct  catttcggt  gctagtcaa  ctcctcctc  1260
ctgcatctg  ccagcagcg  ctttcccaa  tctagctgg  ggtgggcca  gctgatggg  1320
cagaattgg  tacatacac  agcattcct  ttgaacgcc  ccccccacc  ctgggggct  1380
tcatgtttt  aactgccaa  atgctctag  gccttctaa  ggtgttgtc  cttctaggg  1440
tattgcatt  ggattgggg  ccctctaaa  tttaatgca  gatagacac  tatgagggg  1500
aatagtcta  atggctcct  tcagtactt  ggaggcccc  atgtagtcc  tgctgacag  1560
tgctcctag  gggaggggc  taggcctca  ccagagaag  tataaattc  tctttgctt  1620
gctttctgc  cagcttctc  tgtgtgatt  acagctttg  tgctgaagg  tcattttaa  1680
ttattaatt  ctttgagca  aactttaag  ggacataat  ggggcctgg  catcccaca  1740
gtggtggta  ccctggtgg  tgctgtttt  ctcccttct  ctactggca  aaggatctt  1800
gtggccaag  agctgctat  gcctggggt  gggtcatgc  ctcctctcc  attgtccct  1860
tgccccatc  tccagcagg  aaaatgcag  agggatgcc  tggaggtgg  tgagcccct  1920
tctagagag  gaggcaagc  ctgttgaca  aggtctttc  taaggctgc  aggtttagg  1980
tggtggccc  ggaccatca  cctactgta  taaagatga  tgtgaaata  aactggctt  2040
ggcttcttg  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  2095



<210> 1800
<211> 292
<212> PRT
<213> Homo sapiens
<308> P30281
<400> 1800

Met Glu Leu Leu Cys Cys Glu Gly Thr Arg His Ala Pro Arg Ala Gly 
  1               5                  10                  15
Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu 
             20                  25                  30
Arg Leu Glu Glu Arg Tyr Val Pro Arg Ala Ser Tyr Phe Gln Cys Val 
         35                  40                  45
Gln Arg Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Arg Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Thr Arg Lys 
                 85                  90                  95
Ala Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys 
             100                105                110
Leu Arg Glu Thr Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp His Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val 
     130                135                140
Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 
 145                150                155                160
Leu Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala 
                 165                170                175
Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu Cys Ala Thr Asp 
             180                185                190
Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Ile 
         195                200                205
Gly Ala Ala Val Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu 
     210                215                220
Leu Thr Glu Leu Leu Ala Gly Ile Thr Gly Thr Glu Val Asp Cys Leu 
 225                230                235                240
Arg Ala Cys Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg 
                 245                250                255
Glu Ala Ser Gln Thr Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly 
             260                265                270
Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val Thr 
         275                280                285
Ala Ile His Leu 
     290



<210> 1801
<211> 3417
<212> DNA
<213> Rattus norvegicus
<308> D16817
<400> 1801

ggggagaga  ggatagcaa  caagggagg  agagaggga  tgggaggag  aggaggagg  60
gagggagcc  aacgaccat  taaagcgat  gcaatccct  ccctctccc  agtgcttgg  120
tgttggaga  cgcaagagg  aagccaggg  acggggagc  caagctggt  cgccggcca  180
cggagccac  gtgccaggt  ccaaagact  gctgacgcc  tgggacacc  ccaccctct  240
ctgctgcac  tcctcggtc  cctccaccc  ctgtgccta  agaagtccc  gggcttccc  300
caaaggagc  cacctccag  agcccggac  tgggagagc  caccagcat  ccctccagc  360
ccgccgccg  cgctaccgc  gcagcatcc  gagcggcat  gtccagctg  ggaagctgc  420
ccgcgtcct  actttgatg  agttcccct  ctgcgtgct  gaggtgctc  tgtgcgtgc  480
ggcggcggc  gcgcgcggc  aggagatgt  cgccccgca  tcgatccgg  tcgaggggg  540
cgtcaccct  ggggggttg  tcccagtgc  cgccaaggg  cccagcgga  tgccctgcg  600
cgacatcaa  agggagaat  ggatccaca  gctggaagc  atgctttat  ccctggacc  660
gatcaacag  gatcccaac  tgctgccca  tgtaacgtt  ggcgcgcgg  tcctggaca  720
ttgttccag  gacacttat  cgctcgaac  gtcgctcac  ttcgtccag  cgcttatcc  780
gaaggacac  tccgacgtg  gttgcacca  cggagagcc  ccggttttc  tcaagccag  840
gaaagtagt  ggagtgatt  gggcttcgg  gagctccgt  tccatcatg  tagccaaca  900
cttgaggct  tttcagatc  ctcagatta  ttatgcatc  acggctcct  aactcagtg  960
tgaccggcg  tatgacttc  tctctcgag  ggtcccgcc  gattccttc  aagcccagg  1020
gatggttga  attgtaaag  ctttgggct  gaattacgt  tctactctt  catctgaag  1080
aagctatgg  gagaaaggt  tggagtcct  cacacagat  tccaaagag  caggtgggc  1140
ctgcattgc  cagtccgtg  gaatccccc  agagcgcaa  gacaggacc  ttgactttg  1200
tagaattat  aaacagctc  tggacactc  caactccag  gccgtcgtg  tttttgcca  1260
cgatgagga  ataaagcag  tccttgccg  cgccaaaag  gctgaccaa  taggccatt  1320
tctctgggt  gggtcagac  gctggggtt  caaaatcaa  ccactgcat  agcacgaag  1380
tattgcgga  ggagccata  caatccagc  taaaagggc  accgtggaa  gatttgatg  1440
ttacttcac  tcccggaca  ttgaaaaca  caggagaaa  gtatggttt  ccgaatact  1500
ggaagaaaa  ttcaactgc  agttgacaa  tagtgggtc  aaaaaagaa  acacagatc  1560
caaatgcac  ggacaggag  gaattggaa  agactccaa  tatgagcag  aaggtaaag  1620
acagtttgt  attgatgct  tctatgcca  ggcccatgc  cttcatcac  tgaacaagg  1680
tctgtgtgc  gactaccgc  gagtgtgcc  agagatgga  caagcaggc  gcaagaagt  1740
gttgaagta  atccgccat  ttaacttca  tggtagtgc  ggaacccca  taatgttta  1800
caaaaatgg  gatgctcca  ggcgttatg  catcttcca  taccagaca  caaacacaa  1860
caaccctgg  tatcgtctc  ttgggcagt  gacagatga  cttcagctc  atatagagg  1920
catgcagtg  ggcaaagga  tccgagaga  cccatcctc  gtgtgtaca  tgccatgca  1980
gcctgggca  aggaagaag  cacagaagg  aacgccttg  tgctggacc  gtgagccct  2040
tgatggata  cagtatcag  ttgatgaga  gacctgtca  cattgtccc  acgaccaga  2100
gcccaatga  aaccgaact  gctgtcaga  catcccaat  atcaaactg  agtggcact  2160
cccctgggc  gtcattcct  tcttcctgg  aatgttggg  atcattgcc  ccatctttg  2220
catggcaac  ttcatccgc  acaatgaca  acccattgt  agggcatct  ggcgggaac  2280
cagctatgt  ttattgaca  gcatctttc  ctgctatat  atcaccttc  taatgattg  2340
caaaccaga  gtggcagtg  gttctttcc  acgtgtctt  ttgggcttg  gcatgtgta  2400
tagttatgc  gccctttta  caaagacca  tcggattta  cgcatattc  agcagggca  2460
gaaatcggt  acagctccc  gactcataa  cccaacgtc  caactggcg  tcacttcca  2520
tttaatatc  gtgcagctt  taggtgtct  catttggtt  ggggttgac  cccccaaca  2580
tatcataga  tacgatgag  ataagacca  gaacccaga  caagcaagg  gtgttctca  2640
atgtgacat  acagacctt  aaatcattt  ttccctggg  tatagcatt  ttctcatgg  2700
cacatgtac  gtgtatgcc  tcaagactc  gggcgtacc  gagaatttt  atgaagcca  2760
gcccattgg  ttcactatg  acacgacgt  tatcgtatg  cttgccttc  tcccaatat  2820
ttttggcac  gcgcagtca  cagaaaagc  ctacataca  actaccacg  ttacaatct  2880
catgaacct  agtgcgtca  tggcgctgg  aatgctata  atgccgaaa  tgtacatca  2940
cattttcca  cctgaactc  atgtccaga  acggaagcg  agcttcaag  ccgtagtca  3000
agcagccac  atgtcatca  ggctgtcac  caaacccag  gacaggccc  acggtgagg  3060
aaagacaga  ctctgtgaa  atgtagacc  aaacagccc  gctgcaaaa  agaagtatg  3120
cagttataa  aacctggtt  tctaacctg  tccatgcca  ggagccaca  aggaggaag  3180
ccttcagtt  ttctgtcac  cagcctggc  ttggactct  ggtcctgcc  gcttcctat  3240
tctggagga  cttctccac  cgggagagc  atgttagag  atccacaca  cctgaacag  3300
tgctttatg  gacaccttt  ctttatctt  gcttaagaa  tcattggca  cagcactgc  3360
atcttggct  taattctgg  ctccctaag  aaagggaga  ttgagactc  agtccca  3417



<210> 1802
<211> 915
<212> PRT
<213> Rattus norvegicus
<308> P35400
<400> 1802

Met Val Gln Leu Gly Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe 
  1               5                  10                  15
Pro Cys Cys Val Leu Glu Val Leu Leu Cys Val Leu Ala Ala Ala Ala 
             20                  25                  30
Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp 
         35                  40                  45
Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly 
     50                  55                  60
Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu 
 65                  70                  75                  80
Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu 
                 85                  90                  95
Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
             100                105                110
Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln 
         115                120                125
Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe 
     130                135                140
Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
 145                150                155                160
Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln 
                 165                170                175
Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr 
             180                185                190
Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala 
         195                200                205
Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu 
     210                215                220
Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln 
 225                230                235                240
Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile 
                 245                250                255
Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys 
             260                265                270
Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn 
         275                280                285
Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln 
     290                295                300
Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile 
 305                310                315                320
Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile 
                 325                330                335
Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser 
             340                345                350
Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp 
         355                360                365
Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu 
     370                375                380
Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser 
 385                390                395                400
Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr 
                 405                410                415
Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp 
             420                425                430
Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu 
         435                440                445
Leu Lys Tyr Ile Arg His Val Asn Phe Asn Gly Ser Ala Gly Thr Pro 
     450                455                460
Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe 
 465                470                475                480
Gln Tyr Gln Thr Thr Asn Thr Thr Asn Pro Gly Tyr Arg Leu Ile Gly 
                 485                490                495
Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly 
             500                505                510
Lys Gly Val Arg Glu Ile Pro Ser Ser Val Cys Thr Leu Pro Cys Lys 
         515                520                525
Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr 
     530                535                540
Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys 
 545                550                555                560
Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys 
                 565                570                575
Gln Asn Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val 
             580                585                590
Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val 
         595                600                605
Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser 
     610                615                620
Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr 
 625                630                635                640
Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser 
                 645                650                655
Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala 
             660                665                670
Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys 
         675                680                685
Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala 
     690                695                700
Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp 
 705                710                715                720
Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys 
                 725                730                735
Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr 
             740                745                750
Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val 
         755                760                765
Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe 
     770                775                780
Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val 
 785                790                795                800
Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu 
                 805                810                815
Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser 
             820                825                830
Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile 
         835                840                845
Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys 
     850                855                860
Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro 
 865                870                875                880
Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val 
                 885                890                895
Asp Pro Asn Ser Pro Ala Ala Lys Lys Lys Tyr Val Ser Tyr Asn Asn 
             900                905                910
Leu Val Ile 
         915



<210> 1803
<211> 3021
<212> DNA
<213> Homo sapiens
<308> X94552
<400> 1803

gtgagcgcg  gcgcggcgc  ccggccggc  aacccgaga  cgcgaggcg  cccaggctg  60
caggcgccg  gggacccct  accctctct  gtcgcccct  cccggattc  cccaccctc  120
gtgcctgca  gagcccctg  gctttcccg  aggagctcg  cctgaaggg  ccggacctc  180
gcgagccca  caccgttcc  tccagcgcc  ccgccgcca  cgcagcagc  ggagcagca  240
ggtccagct  aggaagctg  tccgcgtcc  gactttgat  aagttcccc  gctgcgtgc  300
ggaggtgct  ctgtgcgcg  tggcggcgg  ggcgcgcgg  caggagatg  acgccccgc  360
ctcaatccg  atcgagggg  acgtcaccc  cggggggct  ttccccgtg  acgccaagg  420
tcccagcgg  gtgccctgc  gcgacatca  gagggaaaa  gggatccac  ggctggaag  480
gatgctcta  gccctggac  agatcaaca  tgatcccaa  ctactgccc  acgtgacgc  540
gggcgcgcg  atcctggac  cttgttcca  ggacactta  gcgctcgaa  agtcgctta  600
tttcgtcca  gcgctcatc  agaaggaca  ctccgacgt  cgctgcacc  acggcgaac  660
gccggtttt  gtcaagccg  agaaagtag  tggagtgat  ggggcttcg  ggagttcgg  720
ctccatcat  gtagccaac  tcctgaggc  cttccagat  ccccagatt  gttatgcat  780
aacggcacc  gagctaagt  atgaccggc  ctatgactt  ttctctcgc  tggtgccac  840
cgattcctt  caagcccag  ccatggtag  cattgtaaa  gccctaggc  ggaattatg  900
gtctaccct  gcatcggaa  gaagttatg  agagaaagg  gtggagtcc  tcacgcaga  960
ttccaaaga  gcaggtgga  tctgcattg  ccagtccgt  agaatcccc  aggaacgca  1020
agacaggac  attgacttt  atagaatta  caaacagct  ctggacacc  ccaactcca  1080
ggccgtcgt  atttttgcc  acgatgagg  tataaagca  atccttgca  cagccaaaa  1140
agctgacca  gttggccat  ttctttggg  gggatcaga  agctgggga  ccaaaataa  1200
cccactgca  cagcatgaa  atatcgcag  aggggccat  accattcag  ccaagcgag  1260
cacggtgga  gggtttgat  cctacttta  gtcccgtac  cttgaaaac  acagaagaa  1320
tgtatggtt  gccgaatac  gggaggaaa  cttcaactg  aagttgacg  ttagtgggt  1380
aaaaaaaga  gacacagat  gcaaatgca  aggacagga  agaattgga  aagattcca  1440
ctatgagca  gagggtaaa  tccagttcg  gattgacgc  gtctatgct  tggctcacg  1500
ccttcacca  atgaacaag  atctctgtg  tgactaccg  ggtgtctgc  cagagatgg  1560
gcaagctgg  ggcaagaag  tgctgaagt  tatacgcaa  gttaatttc  atggtagtg  1620
tggcactcc  gtgatgttt  acaagaacg  ggatgcacc  gggcgttat  acatctttc  1680
gtaccagac  acaaacacc  gcaacccgg  ttaccgtct  atcgggcag  ggacagacg  1740
acttcagct  aatatagaa  acatgcagt  gggtaaagg  gtccgagag  tacccgcct  1800
agtgtgcac  ctaccatgt  agccaggac  gagaaagaa  acacagaaa  gaactcctt  1860
ctgttggac  tgtgagcct  gcgatggtt  ccagtacca  tttgatgag  tgacatgcc  1920
gcattgccc  tatgaccag  ggcccaatg  aaatcgaac  ggatgccag  atattccca  1980
catcaaact  gagtggcac  ccccctggg  tgtgattcc  gtcttcctg  caatgttgg  2040
gatcattgc  accatcttt  tcatggcca  tttcatccg  tacaatgac  cgcccattg  2100
ccgggcatc  gggcgggaa  tcagctatg  tcttttgac  ggcatcttt  tttgctaca  2160
catcacttt  ctgatgatt  ccaaaccag  tgtggcagt  tgttctttc  ggcgagttt  2220
cttgggctt  ggtatgtgc  tcagttatg  agccctctt  acgaaaaca  atcggattt  2280
tcgcatatt  gagcagggc  agaaatcag  aacagctcc  agactcata  gcccaacat  2340
acaactggc  atcacttcc  gtttaatat  agttcagct  ctaggggtg  tcatttggt  2400
tggtgttga  ccacccaac  tcatcatag  ctacgatga  cacaagaca  tgaaccctg  2460
gcaagccag  ggggttctc  agtgtgaca  tacagatct  caaatcatt  gctccttgg  2520
atatagcat  cttctcatg  tcacatgta  tgtgtatgc  atcaagact  ggggtgtac  2580
cgagaattt  aacgaagcc  agcccattg  attcactat  tacacgaca  gtatagtat  2640
gcttgcctt  attccaatt  tttttggca  cgctcaatc  gcggaaaag  tctacatac  2700
aactaccac  cttacaatc  ccatgaacc  aagtgcatc  gtggcgctg  ggatgctat  2760
catgccgaa  gtgtacatc  tcattttcc  ccctgaact  aatgtccag  aacggaagc  2820
aagcttcaa  gcggtagtc  cagcagcca  catgtcatc  aggctgtca  acaaaccca  2880
tgacagacc  aacggtgag  caaagaccg  gctctgtga  aacgtagac  caaacagcc  2940
tgctgcaaa  aagaagtat  tcagttata  taacctggt  atctaacct  ttccattcc  3000
tggaaccat  gaggaggaa  a  3021



<210> 1804
<211> 915
<212> PRT
<213> Homo sapiens
<308> Q14831
<400> 1804

Met Val Gln Leu Arg Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe 
  1               5                  10                  15
Pro Cys Cys Val Leu Glu Val Leu Leu Cys Ala Leu Ala Ala Ala Ala 
             20                  25                  30
Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp 
         35                  40                  45
Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly 
     50                  55                  60
Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu 
 65                  70                  75                  80
Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu 
                 85                  90                  95
Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
             100                105                110
Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln 
         115                120                125
Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe 
     130                135                140
Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
 145                150                155                160
Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln 
                 165                170                175
Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr 
             180                185                190
Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala 
         195                200                205
Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu 
     210                215                220
Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln 
 225                230                235                240
Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile 
                 245                250                255
Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys 
             260                265                270
Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn 
         275                280                285
Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln 
     290                295                300
Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile 
 305                310                315                320
Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile 
                 325                330                335
Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser 
             340                345                350
Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp 
         355                360                365
Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu 
     370                375                380
Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser 
 385                390                395                400
Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr 
                 405                410                415
Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp 
             420                425                430
Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu 
         435                440                445
Leu Lys Tyr Ile Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro 
     450                455                460
Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe 
 465                470                475                480
Gln Tyr Gln Thr Thr Asn Thr Ser Asn Pro Gly Tyr Arg Leu Ile Gly 
                 485                490                495
Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly 
             500                505                510
Lys Gly Val Arg Glu Ile Pro Ala Ser Val Cys Thr Leu Pro Cys Lys 
         515                520                525
Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr 
     530                535                540
Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys 
 545                550                555                560
Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys 
                 565                570                575
Gln Asp Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val 
             580                585                590
Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val 
         595                600                605
Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser 
     610                615                620
Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr 
 625                630                635                640
Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser 
                 645                650                655
Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala 
             660                665                670
Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys 
         675                680                685
Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala 
     690                695                700
Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp 
 705                710                715                720
Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys 
                 725                730                735
Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr 
             740                745                750
Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val 
         755                760                765
Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe 
     770                775                780
Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val 
 785                790                795                800
Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu 
                 805                810                815
Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser 
             820                825                830
Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile 
         835                840                845
Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys 
     850                855                860
Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro 
 865                870                875                880
Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val 
                 885                890                895
Asp Pro Asn Ser Pro Ala Ala Lys Lys Lys Tyr Val Ser Tyr Asn Asn 
             900                905                910
Leu Val Ile 
         915



<210> 1805
<211> 2466
<212> DNA
<213> Rattus norvegicus
<308> D17310
<400> 1805

tttaaatag  aagaaaaaa  tcacagaca  aaaaatttt  gttaccagg  ggccataaa  60
aggtttctt  cccacagtg  actgatagc  gtgacccac  tgtggttcc  atggcgtct  120
ggaagtacc  ccaaccctg  gaaagtgca  tcctcacac  gggctgtct  agaacagtc  180
gaagaccct  gccagaccc  agacctgct  ggttgcatg  gtaacaagc  atggattcc  240
tatctctgc  tgtagcact  aatgatggt  acttcattc  tgtactggg  tttggaacc  300
ctgtgcctg  gaaggttgc  aaggatgaa  ttatcaagg  tactaaaat  gctatagat  360
atggattcc  ccattttga  tctgcttat  tgtacgaag  agaagagga  gtgggccaa  420
ccattagaa  caagattga  gacggcact  tgaagagag  agatatatt  tatacttca  480
agctttgga  cactttcca  agaccagag  tggtccgaa  ttgcttgga  aagacactg  540
aaagcactc  actggacta  gtggatctt  atattattc  tttcccaat  gctttgcag  600
ctggagata  atttttccc  cgagatgag  atggaaaac  attgtttga  acagtggat  660
tctgtgaca  atgggaggc  atggagaag  gtaaggatg  aggattggc  aagtctatt  720
gggtgtcca  ctttaactg  aggcagctg  agaggattc  gaataagcc  gggctcaaa  780
acaagcctg  gtgcaacca  gtggaatgt  acctttatc  caaccagag  aaaatgctg  840
actattgta  gtcaaaaga  atcattctg  tttcctact  cacgctggg  agttcacga  900
acaaaacat  ggtggatca  aaaagtcca  ttctcctag  tgatccagt  ctttgtgcc  960
tagcaaaga  gtacaagca  accccagcc  tagttgccc  tcgctacca  ctgcagcgt  1020
gggttgtgc  cctgatcag  agtttcaac  cgaagcgga  caaagagct  acacaggtt  1080
ttgaattcc  gttggcttc  gaggacatg  aagccctgg  tggcttgaa  agaaatttc  1140
gatacaaca  tgcaaaata  tttgatgac  atcccaatc  tccatttac  gatgaatag  1200
aacatggtg  actttgtca  catttctat  ggaagatct  tttatgcat  gtgatttga  1260
agatatctt  gatactggt  actgaatgc  tcagaccac  gtttctgtt  attcacagt  1320
agctggagc  atgtccaca  tgctatgag  gaagccatg  ttttgtcac  ctctgaaat  1380
gaacatcac  ttgcttttc  ttgtgtttt  aaatattca  ttattttgc  ttccatata  1440
gaatatttt  cctacatgt  tgtgtatct  atgaatgtc  atgtccatg  agggttgaa  1500
agtgttgca  gtcacttgg  accggagtt  cattgatta  ggagttacc  tgtgggtgc  1560
gggagccaa  cctaggtct  ctgtgagac  agcaagtgc  tttgaatgc  gagccatct  1620
attaggtcc  accctaaag  tccttgcct  ccactattt  tgtgatctc  atgttttgt  1680
ttctcctga  ttctgacac  aagctgatt  gctagaagt  ttgggcatg  agtgggtgt  1740
gaggacagt  attgcaaag  gatttctgg  tgggagttg  aagaacgtt  aacattcag  1800
gaattaatt  ttcgaggtt  ttgattagt  aatattccc  atattcttt  aggaagaag  1860
aagtactcc  tagattttc  ctttttctt  gttttgagg  agggcacct  tggcaggag  1920
gaccaagag  cccagggtt  tctccaaca  cccaagaac  agagctcca  gaacctgga  1980
agcaagttc  tgtgggaag  ttggaatgt  ggtaagaag  gaaccaatc  aaaagcatc  2040
tcatgattc  gatgtgggg  gtttgagag  aaatttgaa  gtgtctctc  ttttgggaa  2100
tatatcatc  tttttcttt  tgtaattac  tgttgggag  aatgccctt  aaaccctcc  2160
ttattgatg  aatggttag  attaagtat  actgggttc  tggaaaatc  ccagccagc  2220
gcagaagac  aatacaaat  tggtggtca  gatgaataa  gatatgata  agttctgac  2280
ttgctgaga  atacatctg  catcaagat  cccaatgtg  tgacctgta  gctttctga  2340
aaaccaaca  cctgttgac  tcagctgac  acatgtata  tgtgccctt  gcctgtgta  2400
atgtttcac  cttcccccc  ccctctgtt  cccatgtta  ggtataaat  cagccttgg  2460
aaaaaa  2466



<210> 1806
<211> 322
<212> PRT
<213> Rattus norvegicus
<308> P23457
<400> 1806

Met Asp Ser Ile Ser Leu Arg Val Ala Leu Asn Asp Gly Asn Phe Ile 
  1               5                  10                  15
Pro Val Leu Gly Phe Gly Thr Thr Val Pro Glu Lys Val Ala Lys Asp 
             20                  25                  30
Glu Val Ile Lys Ala Thr Lys Ile Ala Ile Asp Asn Gly Phe Arg His 
         35                  40                  45
Phe Asp Ser Ala Tyr Leu Tyr Glu Val Glu Glu Glu Val Gly Gln Ala 
     50                  55                  60
Ile Arg Ser Lys Ile Glu Asp Gly Thr Val Lys Arg Glu Asp Ile Phe 
 65                  70                  75                  80
Tyr Thr Ser Lys Leu Trp Ser Thr Phe His Arg Pro Glu Leu Val Arg 
                 85                  90                  95
Thr Cys Leu Glu Lys Thr Leu Lys Ser Thr Gln Leu Asp Tyr Val Asp 
             100                105                110
Leu Tyr Ile Ile His Phe Pro Met Ala Leu Gln Pro Gly Asp Ile Phe 
         115                120                125
Phe Pro Arg Asp Glu His Gly Lys Leu Leu Phe Glu Thr Val Asp Ile 
     130                135                140
Cys Asp Thr Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
 145                150                155                160
Lys Ser Ile Gly Val Ser Asn Phe Asn Cys Arg Gln Leu Glu Arg Ile 
                 165                170                175
Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
             180                185                190
Cys His Leu Tyr Leu Asn Gln Ser Lys Met Leu Asp Tyr Cys Lys Ser 
         195                200                205
Lys Asp Ile Ile Leu Val Ser Tyr Cys Thr Leu Gly Ser Ser Arg Asp 
     210                215                220
Lys Thr Trp Val Asp Gln Lys Ser Pro Val Leu Leu Asp Asp Pro Val 
 225                230                235                240
Leu Cys Ala Ile Ala Lys Lys Tyr Lys Gln Thr Pro Ala Leu Val Ala 
                 245                250                255
Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Pro Leu Ile Arg Ser Phe 
             260                265                270
Asn Ala Lys Arg Ile Lys Glu Leu Thr Gln Val Phe Glu Phe Gln Leu 
         275                280                285
Ala Ser Glu Asp Met Lys Ala Leu Asp Gly Leu Asn Arg Asn Phe Arg 
     290                295                300
Tyr Asn Asn Ala Lys Tyr Phe Asp Asp His Pro Asn His Pro Phe Thr 
 305                310                315                320
Asp Glu 
                 325



<210> 1807
<211> 1104
<212> DNA
<213> Homo sapiens
<308> NM_014342
<400> 1807

ggtcgcttg  tggctccgt  tgttgtccg  ccgcccgcg  gtgccatca  ggcggacgc  60
gccagtcag  tgctcctgg  ctccggtct  accatcctg  cccagccgc  catgtacgt  120
aaagtgctc  tccaggtgg  atatgagcc  cttcctcca  caataggac  aaatatttt  180
gggcggcaa  tgtgtcagc  tcctggtct  tttagttat  ctcagcaca  tgccagtat  240
gatgggagg  gcgggttgt  cacaggctt  actccaaga  tgtgttcgg  agtccttgg  300
actgtggtc  atggtaaag  tttacagca  taccaggag  gtgacaagg  tgaggagtt  360
ggacctgga  atgtacaga  agaagtctc  tcttccttt  accacgtta  caaggagac  420
actcgagag  tgatcgctc  ttctgctgc  accctcatc  cacatccct  ccatgtgat  480
actctgaga  ctatggtac  gttcattgg  agagaatcc  agtactgtg  actttgtga  540
tccataata  ccatctatc  ggaagaggg  attctagga  ttttcgcgg  tcttgttcc  600
cgccttcta  gtgacatcc  ttctttgtg  ctgtgtaac  cactggcct  cctcgtcaa  660
acctatgca  tggacagtg  ggtttctac  atgaatgaa  tgaagagtt  ttctcaagc  720
gtcacagga  tttttgcga  tatgttgac  tatcccttt  tgcttgtct  caatcttat  780
gctgtcaac  actgtggtc  tgctggtgg  tgccctcct  actccccaa  atatacgtc  840
tggatagac  gttggtgca  gctacaaaa  gaggggaat  tgagccgag  aaatagctt  900
tttttccgg  aggtcccct  tgggaagac  tattgttgt  acctgaaaa  gttaatttg  960
agatgtggg  cagggacag  gacatttct  tagtcccag  tgcacagaa  tatgggaga  1020
aatgttgat  tctatacag  gtggcgcgc  tttttaata  tcatttaat  ttgggaaaa  1080
taaaaaaaa  aaaaaaaaa  aaaa  1104



<210> 1808
<211> 323
<212> PRT
<213> Homo sapiens
<308> BAA99542
<400> 1808

Met Asp Pro Lys Tyr Gln Arg Val Glu Leu Asn Asp Gly His Phe Met 
  1               5                  10                  15
Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Pro Glu Val Pro Arg Asn 
             20                  25                  30
Arg Ala Val Glu Val Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
         35                  40                  45
Ile Asp Ser Ala Tyr Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
     50                  55                  60
Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
 65                  70                  75                  80
Tyr Thr Ser Lys Leu Trp Cys Thr Phe Phe Gln Pro Gln Met Val Gln 
                 85                  90                  95
Pro Ala Leu Glu Ser Ser Leu Lys Lys Leu Gln Leu Asp Tyr Val Asp 
             100                105                110
Leu Tyr Leu Leu His Phe Pro Met Ala Leu Lys Pro Gly Glu Thr Pro 
         115                120                125
Leu Pro Lys Asp Glu Asn Gly Lys Val Ile Phe Asp Thr Val Asp Leu 
     130                135                140
Ser Ala Thr Trp Glu Val Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
 145                150                155                160
Lys Ser Ile Gly Val Ser Asn Phe Asn Cys Arg Gln Leu Glu Met Ile 
                 165                170                175
Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
             180                185                190
Cys His Pro Tyr Leu Asn Gln Ser Lys Leu Leu Asp Phe Cys Lys Ser 
         195                200                205
Lys Asp Ile Val Leu Val Ala His Ser Ala Leu Gly Thr Gln Arg His 
     210                215                220
Lys Leu Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
 225                230                235                240
Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 
                 245                250                255
Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
             260                265                270
Asn Glu Gln Arg Ile Arg Glu Asn Ile Gln Val Phe Glu Phe Gln Leu 
         275                280                285
Thr Ser Glu Asp Met Lys Val Leu Asp Gly Leu Asn Arg Asn Tyr Arg 
     290                295                300
Tyr Val Val Met Asp Phe Leu Met Asp His Pro Asp Tyr Pro Phe Ser 
 305                310                315                320
Asp Glu Tyr 
                 325



<210> 1809
<211> 1743
<212> DNA
<213> Rattus norvegicus
<308> D17370
<400> 1809

ccgtcccag  atgcagaag  acgcctcct  cagcggctt  ctgcccagc  tccagcact  60
tgccactca  gccatccac  tgggaccag  gccggagca  tggagttcg  gtgctgtgg  120
gctgcccat  tcgctggcc  ccacgttca  acaggactc  ccaggccag  cctcgggtt  180
tgtatacag  cgctctgga  atccgacga  gaattgctt  gaaaaagca  tggctgcac  240
ggatggggc  aagcactgt  tgaccttcg  tcggggcct  gccgccacc  caacgatta  300
ccatctttt  aaagcagga  atgaagtca  ttgcatgga  gaagtgtat  gaggcacca  360
caggtactt  aggagggtg  catccgagt  tggactgaa  atttctttt  tggattgtt  420
caaaaccaa  ttgctggag  cagcgatca  accacagac  aagcttgtt  ggattgaaa  480
acccacaaa  ccaaccttg  agttggccg  catcaaagc  tgcgcacaa  ttgtccaca  540
acacaaaga  atcattctg  ttgtagata  cactttcat  tctgcatat  tccagagac  600
tttggctct  ggtgctgat  tttgtatgt  ttctgccac  aaatacatg  acggccaca  660
tgatgttgt  atgggctta  tgtctgtta  ttccgatga  ctcaacgaa  ggcttcgtt  720
cctgcagaa  tctctcggg  cagttcctt  tcctttcga  tgttacctc  gctgccgag  780
cctgaagac  ctgcagatc  ggatggaga  acacttcag  aatgggatg  cagtggccc  840
tttcctgga  tctaatccc  gggtagaaa  ggttattta  cctgggcta  cgtctcacc  900
tcagcatga  ctcgccaaa  gtcagtgca  gggctgccc  gggatggtc  gtttctata  960
caagggtac  ctgcagcat  ctcaggtct  cctcaaaaa  ataaagctg  ttgctctgg  1020
tgagagcct  ggaggatat  agagtctgg  tgagcttcc  gcaatcatg  cccatgcct  1080
cgtgcctga  aaggacaga  ctaccctcg  gatcagtga  acactgatc  gactttctg  1140
gggcctaga  gatgaaaag  accttctcg  agacctggg  caagcttta  aggcagcgc  1200
cccttaaag  tcgagtcaa  gccggcatt  cagtgctgc  atcagcagc  gcagccaag  1260
ggccagacc  tctgaataa  tggacagac  attaaggag  atctgcaga  cttcgcagt  1320
aacatttta  gaccctagt  attttacag  tgtaacctt  cagggatct  cccttaagg  1380
ctgtcttct  ctaacaggt  gttctgtta  tatcattct  atagttttg  tgtatttgt  1440
ttcaaggaa  agagttgta  tattttggg  atcatgttg  ttctttttt  ctttttctt  1500
cttcggtag  ctaagatat  ttttaatca  gtttacaaa  tttagtatt  atgttttat  1560
aagttaaat  attcaatga  cggtcttaa  tcaactgta  gggtttttt  tttgaaaaa  1620
tattgaaag  ggggggtct  tatttaatt  ccataagcc  aaaaaatca  atatttgga  1680
tatctactg  gaaattcta  tgattaaag  ttgtacttg  tacttgttg  ttttcttaa  1740
tgg  1743



<210> 1810
<211> 398
<212> PRT
<213> Rattus norvegicus
<308> P18757
<400> 1810

Met Gln Lys Asp Ala Ser Ser Ser Gly Phe Leu Pro Ser Phe Gln His 
  1               5                  10                  15
Phe Ala Thr Gln Ala Ile His Val Gly Pro Glu Pro Glu Gln Trp Ser 
             20                  25                  30
Ser Arg Ala Val Val Leu Pro Ile Ser Leu Ala Thr Thr Phe Lys Gln 
         35                  40                  45
Asp Ser Pro Gly Gln Ser Ser Gly Phe Val Tyr Ser Arg Ser Gly Asn 
     50                  55                  60
Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly Ala 
 65                  70                  75                  80
Lys His Cys Leu Thr Phe Ala Arg Gly Leu Ala Ala Thr Thr Thr Ile 
                 85                  90                  95
Thr His Leu Leu Lys Ala Gly Asp Glu Val Ile Cys Met Asp Glu Val 
             100                105                110
Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Arg Val Ala Ser Glu Phe Gly 
         115                120                125
Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Thr Lys Leu Leu Glu Ala 
     130                135                140
Ala Ile Thr Pro Gln Thr Lys Leu Val Trp Ile Glu Thr Pro Thr Asn 
 145                150                155                160
Pro Thr Leu Lys Leu Ala Asp Ile Lys Ala Cys Ala Gln Ile Val His 
                 165                170                175
Lys His Lys Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser Ala 
             180                185                190
Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Cys Met Cys Ser 
         195                200                205
Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu Val 
     210                215                220
Ser Val Thr Ser Asp Asp Leu Asn Glu Arg Leu Arg Phe Leu Gln Asn 
 225                230                235                240
Ser Leu Gly Ala Val Pro Ser Pro Phe Asp Cys Tyr Leu Cys Cys Arg 
                 245                250                255
Gly Leu Lys Thr Leu Gln Ile Arg Met Glu Lys His Phe Arg Asn Gly 
             260                265                270
Met Ala Val Ala Arg Phe Leu Glu Ser Asn Pro Arg Val Glu Lys Val 
         275                280                285
Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Ala Lys Arg 
     290                295                300
Gln Cys Thr Gly Cys Pro Gly Met Val Ser Phe Tyr Ile Lys Gly Thr 
 305                310                315                320
Leu Gln His Ala Gln Val Phe Leu Lys Asn Ile Lys Leu Phe Ala Leu 
                 325                330                335
Ala Glu Ser Leu Gly Gly Tyr Glu Ser Leu Ala Glu Leu Pro Ala Ile 
             340                345                350
Met Thr His Ala Ser Val Pro Glu Lys Asp Arg Ala Thr Leu Gly Ile 
         355                360                365
Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Lys Asp 
     370                375                380
Leu Leu Glu Asp Leu Gly Gln Ala Leu Lys Ala Ala His Pro 
 385                390                395



<210> 1811
<211> 1194
<212> DNA
<213> Homo sapiens
<308> S52028
<400> 1811

ttcttttcc  ctcttcttc  ttcgcggtt  agcatgcag  aaaaagacg  ctcctcaca  60
ggtttcctg  cacacttcc  acatttcgc  acgcaggcg  tccatgtgg  ccaggatcc  120
gagcaatgg  cctccaggg  tgtagtgcc  cccatctca  tgtccacca  gttcaagca  180
ggggcgcct  gccagcact  gggttttga  tatagccgt  ctggaaatc  cactaggaa  240
tgccttgaa  aagcagtgg  agcactgga  ggggctaag  actgtttgg  ctttgcttc  300
ggtttagca  ccactgtaa  tattaccca  cttttaaaa  caggagacc  aattatttg  360
atggatgat  tgtatggag  tacaaacag  tacttcagg  aagtggcat  tgaatttgg  420
ttaaagatt  cttttgttg  ttgttccaa  atcaaatta  tagaggcag  aattacacc  480
gaaaccaag  gccctttgg  tctgggagc  gatatttct  tgtattctg  aacaaaata  540
atgaatggc  acagtgatg  tgtaatggg  ctggtgtct  ttaattgtg  aagccttca  600
aatagactt  gtttcttgc  aaactctct  ggagcagtt  catctccta  tgattgtta  660
ctctgcaat  gaggtctga  gactctaca  gtccgaatg  aaaagcatt  caaaaacgg  720
atggcagtt  cccagttcc  ggaatctaa  ccttgggta  aaaaggtta  ttatcctgg  780
ctgccctct  atccacagc  tgagttggt  aagcgtcag  gtacaggtt  tacagggat  840
gtcaccttt  atattaagg  cactcttca  catgctgag  ttttcctca  gaacctaaa  900
ctatttact  tggccgaga  cttgggagg  ttcgaaagc  ttgctgagc  tccggcaat  960
atgactcat  catcagttc  taagaatga  agagatgtc  ttggaatta  tgacacact  1020
attcgactt  ctgtgggct  agaggatga  gaagaccta  tggaagatc  agatcaagc  1080
ttgaaggca  cacaccctc  aagtggaat  cacagctag  attccagag  tgctattag  1140
agctgcttc  tgtgaagat  aatcttcct  agtaattaa  ggaccaaca  tgag  1194



<210> 1812
<211> 405
<212> PRT
<213> Homo sapiens
<308> P32929
<400> 1812

Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
  1               5                  10                  15
His Phe Ala Thr Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
             20                  25                  30
Thr Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Thr Thr Phe Lys 
         35                  40                  45
Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
     50                  55                  60
Asn Pro Thr Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
 65                  70                  75                  80
Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Thr Val Thr 
                 85                  90                  95
Ile Thr His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
             100                105                110
Val Tyr Gly Gly Thr Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
         115                120                125
Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
     130                135                140
Ala Ala Ile Thr Pro Glu Thr Lys Leu Val Trp Ile Glu Thr Pro Thr 
 145                150                155                160
Asn Pro Thr Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                 165                170                175
His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Thr Phe Met Ser 
             180                185                190
Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
         195                200                205
Ser Ala Thr Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
     210                215                220
Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
 225                230                235                240
Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                 245                250                255
Arg Gly Leu Lys Thr Leu His Val Arg Met Glu Lys His Phe Lys Asn 
             260                265                270
Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
         275                280                285
Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
     290                295                300
Arg Gln Cys Thr Gly Cys Thr Gly Met Val Thr Phe Tyr Ile Lys Gly 
 305                310                315                320
Thr Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Thr 
                 325                330                335
Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
             340                345                350
Ile Met Thr His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
         355                360                365
Ile Ser Asp Thr Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
     370                375                380
Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
 385                390                395                400
Ser Gly Ile His Ser 
                 405



<210> 1814
<211> 760
<212> PRT
<213> Rattus norvegicus
<308> BAA04471
<400> 1814

Met Thr Asn Gly Gly Ser Ile Asn Ser Ser Thr His Leu Leu Asp Leu 
  1               5                  10                  15
Leu Asp Glu Pro Ile Pro Gly Val Gly Thr Tyr Asp Asp Phe His Thr 
             20                  25                  30
Ile Asp Trp Val Arg Glu Lys Cys Lys Asp Arg Glu Arg His Arg Arg 
         35                  40                  45
Ile Asn Ser Lys Lys Lys Glu Ser Ala Trp Glu Met Thr Lys Ser Leu 
     50                  55                  60
Tyr Asp Ala Trp Ser Gly Trp Leu Val Val Thr Leu Thr Gly Leu Ala 
 65                  70                  75                  80
Ser Gly Ala Leu Ala Gly Leu Ile Asp Ile Ala Ala Asp Trp Met Thr 
                 85                  90                  95
Asp Leu Lys Glu Gly Ile Cys Leu Ser Ala Leu Trp Tyr Asn His Glu 
             100                105                110
Gln Cys Cys Trp Gly Ser Asn Glu Thr Thr Phe Glu Glu Arg Asp Lys 
         115                120                125
Cys Pro Gln Trp Lys Thr Trp Ala Glu Leu Ile Ile Gly Gln Ala Glu 
     130                135                140
Gly Pro Gly Ser Tyr Ile Met Asn Tyr Ile Met Tyr Ile Phe Trp Ala 
 145                150                155                160
Leu Ser Phe Ala Phe Leu Ala Val Ser Leu Val Lys Val Phe Ala Pro 
                 165                170                175
Tyr Ala Cys Gly Ser Gly Ile Pro Glu Ile Lys Thr Ile Leu Ser Gly 
             180                185                190
Phe Ile Ile Arg Gly Tyr Leu Gly Lys Trp Thr Leu Met Ile Lys Thr 
         195                200                205
Ile Thr Leu Val Leu Ala Val Ala Ser Gly Leu Ser Leu Gly Lys Glu 
     210                215                220
Gly Pro Leu Val His Val Ala Cys Cys Cys Gly Asn Ile Phe Ser Tyr 
 225                230                235                240
Leu Phe Pro Lys Tyr Ser Thr Asn Glu Ala Lys Lys Arg Glu Val Leu 
                 245                250                255
Ser Ala Ala Ser Ala Ala Gly Val Ser Val Ala Phe Gly Ala Pro Ile 
             260                265                270
Gly Gly Val Leu Phe Ser Leu Glu Glu Val Ser Tyr Tyr Phe Pro Leu 
         275                280                285
Lys Thr Leu Trp Arg Ser Phe Phe Ala Ala Leu Val Ala Ala Phe Val 
     290                295                300
Leu Arg Ser Ile Asn Pro Phe Gly Asn Ser Arg Leu Val Leu Phe Tyr 
 305                310                315                320
Val Glu Tyr His Thr Pro Trp Tyr Leu Phe Glu Leu Phe Pro Phe Ile 
                 325                330                335
Leu Leu Gly Val Phe Gly Gly Leu Trp Gly Ala Phe Phe Ile Arg Ala 
             340                345                350
Asn Ile Ala Trp Cys Arg Arg Arg Lys Ser Thr Lys Phe Gly Lys Tyr 
         355                360                365
Pro Val Leu Glu Val Ile Ile Val Ala Ala Ile Thr Ala Val Ile Ala 
     370                375                380
Phe Pro Asn Pro Tyr Thr Arg Leu Asn Thr Ser Glu Leu Ile Lys Glu 
 385                390                395                400
Leu Phe Thr Asp Cys Gly Pro Leu Glu Ser Ser Ser Leu Cys Asp Tyr 
                 405                410                415
Arg Asn Asp Met Asn Ala Ser Lys Ile Val Asp Asp Ile Pro Asp Arg 
             420                425                430
Pro Ala Gly Val Gly Val Tyr Ser Ala Ile Trp Gln Leu Cys Leu Ala 
         435                440                445
Leu Ile Phe Lys Ile Ile Met Thr Val Phe Thr Phe Gly Ile Lys Val 
     450                455                460
Pro Ser Gly Leu Phe Ile Pro Ser Met Ala Ile Gly Ala Ile Ala Gly 
 465                470                475                480
Arg Ile Val Gly Ile Ala Val Glu Gln Leu Ala Tyr Tyr His His Asp 
                 485                490                495
Trp Phe Ile Phe Lys Glu Trp Cys Glu Val Gly Ala Asp Cys Ile Thr 
             500                505                510
Pro Gly Leu Tyr Ala Met Val Gly Ala Ala Ala Cys Leu Gly Gly Val 
         515                520                525
Thr Arg Met Thr Val Ser Leu Val Val Ile Val Phe Glu Leu Thr Gly 
     530                535                540
Gly Leu Glu Tyr Ile Val Pro Leu Met Ala Ala Val Met Thr Ser Lys 
 545                550                555                560
Trp Val Gly Asp Ala Phe Gly Arg Glu Gly Ile Tyr Glu Ala His Ile 
                 565                570                575
Arg Leu Asn Gly Tyr Pro Phe Leu Asp Ala Lys Glu Glu Phe Thr His 
             580                585                590
Thr Thr Leu Ala Ala Asp Val Met Arg Pro Arg Arg Ser Asp Pro Pro 
         595                600                605
Leu Ala Val Leu Thr Gln Asp Asn Met Thr Val Asp Asp Ile Glu Asn 
     610                615                620
Met Ile Asn Glu Thr Ser Tyr Asn Gly Phe Pro Val Ile Met Ser Lys 
 625                630                635                640
Glu Ser Gln Arg Leu Val Gly Phe Ala Leu Arg Arg Asp Leu Thr Ile 
                 645                650                655
Ala Ile Glu Ser Ala Arg Lys Lys Gln Glu Gly Val Val Gly Ser Ser 
             660                665                670
Arg Val Cys Phe Ala Gln His Thr Pro Ser Leu Pro Ala Glu Ser Pro 
         675                680                685
Arg Pro Leu Lys Leu Arg Ser Ile Leu Asp Met Ser Pro Phe Thr Val 
     690                695                700
Thr Asp His Thr Pro Met Glu Ile Val Val Asp Val Phe Arg Lys Leu 
 705                710                715                720
Gly Leu Arg Gln Cys Leu Val Thr His Asn Gly Arg Leu Leu Gly Ile 
                 725                730                735
Ile Thr Lys Lys Asp Ile Leu Arg His Met Ala Gln Thr Ala Asn Gln 
             740                745                750
Asp Pro Ala Ser Ile Met Phe Asn 
         755                760



<210> 1815
<211> 3953
<212> DNA
<213> Homo sapiens
<308> NM_001829
<400> 1815

ggggtcacg  gcgaactag  acactggga  aggggctgc  ggttccgga  cggaccggc  2940
ctgacccgg  ataatgagc  aggagggtg  ggtgggttg  aagccatcc  actttactc  3000
cgagttaga  catggattc  gttttagtc  taaggggga  gtgagattg  agattttta  3060
ttttaattt  gggcagaag  aggttgact  tagggatct  cagagcgag  ggatttaac  3120
tcatgttgc  cccgtgttt  aaggaggac  ataaaagtc  caccgggca  aattttcgt  3180
acctctgcg  tagaaaacg  caggtatct  ttaaatcgc  atagttttc  ctgtgtcag  3240
ctttcttcg  tggagctcc  agggtagct  ggttctagg  ttgaaacag  tgcagaatc  3300
aaaggcagc  caaaaaaca  ccaccgatt  tgctatgtc  ctgagctgc  agataatca  3360
acagctaaa  ggagtctga  cagctgttc  atagaggct  ctatagaaa  agctacaac  3420
gtataacaa  tgcaagtag  gatgaggaa  ttttagatg  agcaggtgt  attatggac  3480
ttcaaacat  tgaagatga  aatttatta  atggtgaca  tgcagttgg  actcattat  3540
caatgacaa  tggaggcag  attaacagt  ctacacatt  actggatct  ttggatgaa  3600
caattccag  tgttggtac  tatgatgat  tccatacta  tgattgggt  cgagaaaaa  3660
gtaaagaca  agaaaggca  agacggatc  acagcaaaa  gaaagaatc  gcatgggaa  3720
tgacaaaaa  tttgtatga  gcgtggtca  gatggctag  agtaacact  acaggattg  3780
catcagggg  actggccgg  ttaatagac  ttgctgccg  ttggatgac  gacctaaag  3840
agggcattt  ccttagtgc  ttgtggtac  accacgaac  gtgctgttg  ggatctaat  3900
aaacaacat  tgaagagag  gataaatgt  cacagtgga  aacatgggc  gaa  3953



<210> 1816
<211> 820
<212> PRT
<213> Homo sapiens
<308> NP_001820
<400> 1816

Met Glu Ser Glu Gln Leu Phe His Arg Gly Tyr Tyr Arg Asn Ser Tyr 
  1               5                  10                  15
Asn Ser Ile Thr Ser Ala Ser Ser Asp Glu Glu Leu Leu Asp Gly Ala 
             20                  25                  30
Gly Val Ile Met Asp Phe Gln Thr Ser Glu Asp Asp Asn Leu Leu Asp 
         35                  40                  45
Gly Asp Thr Ala Val Gly Thr His Tyr Thr Met Thr Asn Gly Gly Ser 
     50                  55                  60
Ile Asn Ser Ser Thr His Leu Leu Asp Leu Leu Asp Glu Pro Ile Pro 
 65                  70                  75                  80
Gly Val Gly Thr Tyr Asp Asp Phe His Thr Ile Asp Trp Val Arg Glu 
                 85                  90                  95
Lys Cys Lys Asp Arg Glu Arg His Arg Arg Ile Asn Ser Lys Lys Lys 
             100                105                110
Glu Ser Ala Trp Glu Met Thr Lys Ser Leu Tyr Asp Ala Trp Ser Gly 
         115                120                125
Trp Leu Val Val Thr Leu Thr Gly Leu Ala Ser Gly Ala Leu Ala Gly 
     130                135                140
Leu Ile Asp Ile Ala Ala Asp Trp Met Thr Asp Leu Lys Glu Gly Ile 
 145                150                155                160
Cys Leu Ser Ala Leu Trp Tyr Asn His Glu Gln Cys Cys Trp Gly Ser 
                 165                170                175
Asn Glu Thr Thr Phe Glu Glu Arg Asp Lys Cys Pro Gln Trp Lys Thr 
             180                185                190
Trp Ala Glu Leu Ile Ile Gly Gln Ala Glu Gly Pro Gly Ser Tyr Ile 
         195                200                205
Met Asn Tyr Ile Met Tyr Ile Phe Trp Ala Leu Ser Phe Ala Phe Leu 
     210                215                220
Ala Val Ser Leu Val Lys Val Phe Ala Pro Tyr Ala Cys Gly Ser Gly 
 225                230                235                240
Ile Pro Glu Ile Lys Thr Ile Leu Ser Gly Phe Ile Ile Arg Gly Tyr 
                 245                250                255
Leu Gly Lys Trp Thr Leu Met Ile Lys Thr Ile Thr Leu Val Leu Ala 
             260                265                270
Val Ala Ser Gly Leu Ser Leu Gly Lys Glu Gly Pro Leu Val His Val 
         275                280                285
Ala Cys Cys Cys Gly Asn Ile Phe Ser Tyr Leu Phe Pro Lys Tyr Ser 
     290                295                300
Thr Asn Glu Ala Lys Lys Arg Glu Val Leu Ser Ala Ala Ser Ala Ala 
 305                310                315                320
Gly Val Ser Val Ala Phe Gly Ala Pro Ile Gly Gly Val Leu Phe Ser 
                 325                330                335
Leu Glu Glu Val Ser Tyr Tyr Phe Pro Leu Lys Thr Leu Trp Arg Ser 
             340                345                350
Phe Phe Ala Ala Leu Val Ala Ala Phe Val Leu Arg Ser Ile Asn Pro 
         355                360                365
Phe Gly Asn Ser Arg Leu Val Leu Phe Tyr Val Glu Tyr His Thr Pro 
     370                375                380
Trp Tyr Leu Phe Glu Leu Phe Pro Phe Ile Leu Leu Gly Val Phe Gly 
 385                390                395                400
Gly Leu Trp Gly Ala Phe Phe Ile Arg Ala Asn Ile Ala Trp Cys Arg 
                 405                410                415
Arg Arg Lys Ser Thr Lys Phe Gly Lys Tyr Pro Val Leu Glu Val Ile 
             420                425                430
Ile Val Ala Ala Ile Thr Ala Val Ile Ala Phe Pro Asn Pro Tyr Thr 
         435                440                445
Arg Leu Asn Thr Ser Glu Leu Ile Lys Glu Leu Phe Thr Asp Cys Gly 
     450                455                460
Pro Leu Glu Ser Ser Ser Leu Cys Asp Tyr Arg Asn Asp Met Asn Ala 
 465                470                475                480
Ser Lys Ile Val Asp Asp Ile Pro Asp Arg Pro Ala Gly Ile Gly Val 
                 485                490                495
Tyr Ser Ala Ile Trp Gln Leu Cys Leu Ala Leu Ile Phe Lys Ile Ile 
             500                505                510
Met Thr Val Phe Thr Phe Gly Ile Lys Val Pro Ser Gly Leu Phe Ile 
         515                520                525
Pro Ser Met Ala Ile Gly Ala Ile Ala Gly Arg Ile Val Gly Ile Ala 
     530                535                540
Val Glu Gln Leu Ala Tyr Tyr His His Asp Trp Phe Ile Phe Lys Glu 
 545                550                555                560
Trp Cys Glu Val Gly Ala Asp Cys Ile Thr Pro Gly Leu Tyr Ala Met 
                 565                570                575
Val Gly Ala Ala Ala Cys Leu Gly Gly Val Thr Arg Met Thr Val Ser 
             580                585                590
Leu Val Val Ile Val Phe Glu Leu Thr Gly Gly Leu Glu Tyr Ile Val 
         595                600                605
Pro Leu Met Ala Ala Val Met Thr Ser Lys Trp Val Gly Asp Ala Phe 
     610                615                620
Gly Arg Glu Gly Ile Tyr Glu Ala His Ile Arg Leu Asn Gly Tyr Pro 
 625                630                635                640
Phe Leu Asp Ala Lys Glu Glu Phe Glu Phe Thr His Thr Thr Leu Ala 
                 645                650                655
Ala Asp Val Met Arg Pro Arg Arg Asn Asp Pro Pro Leu Ala Val Leu 
             660                665                670
Thr Gln Asp Asn Met Thr Val Asp Asp Ile Glu Asn Met Ile Asn Glu 
         675                680                685
Thr Ser Tyr Asn Gly Phe Pro Val Ile Met Ser Lys Glu Ser Gln Arg 
     690                695                700
Leu Val Gly Phe Ala Leu Arg Arg Asp Leu Thr Ile Ala Ile Glu Ser 
 705                710                715                720
Ala Arg Lys Lys Gln Glu Gly Ile Val Gly Ser Ser Arg Val Cys Phe 
                 725                730                735
Ala Gln His Thr Pro Ser Leu Pro Ala Glu Ser Pro Arg Pro Leu Lys 
             740                745                750
Leu Arg Ser Ile Leu Asp Met Ser Pro Phe Thr Val Thr Asp His Thr 
         755                760                765
Pro Met Glu Ile Val Val Asp Ile Phe Arg Lys Leu Gly Leu Arg Gln 
     770                775                780
Cys Leu Val Thr His Asn Gly Arg Leu Leu Gly Ile Ile Thr Lys Lys 
 785                790                795                800
Asp Ile Leu Arg His Met Ala Gln Thr Ala Asn Gln Asp Pro Ala Ser 
                 805                810                815
Ile Met Phe Asn 
             820



<210> 1817
<211> 2099
<212> DNA
<213> Rattus norvegicus
<308> D17614
<400> 1817

agatcaaag  ggtgggact  gcgtcgcgg  cgcggagac  agaaggagg  ctccggatc  60
ggctcggcg  tcgccctcg  tcgccatgg  gaagaccga  ctgatccag  aggccaagc  120
ggccgagca  gccgagcgc  acgacgaca  ggccacctg  atgaaagcc  tgacggagc  180
gggcgccga  ctgtccaac  aggagcgca  cctgctatc  gtggcctac  agaacgtgg  240
cgggggccg  aggtccgcc  ggagggtca  ctcgagcat  gagcagaag  ccgatacct  300
ggacaagaa  ttgcagctg  tcaaggact  tcgggagaa  gtggagtct  agctgaggt  360
catctgcac  acggtcctg  aattgttgg  taagtattt  atagccaat  caactaatc  420
agagagtaa  gtcttctat  tgaaaatga  gggagatta  ttccggtat  ttgctgaag  480
cgcttgtgg  gatgatcga  aacaaacga  agaaaattc  caaggagcc  accaagagg  540
atttgatat  agcaagaaa  agatgcaac  tacacatcc  atccgcctg  ggctggctc  600
taacttttc  gtattttac  atgagatcc  taataatcc  gagcttgcc  gcacactgg  660
taaaacggc  tttgatgaa  ccatcgccg  gcttgatac  ctgaatgaa  actcctaca  720
agacagcac  ctcatcatg  agttgctta  agacaactt  acattatgg  catcagaca  780
tgcaggaga  gaatgtgat  cagctgagg  ggctgagaa  taaaggcat  caggacacc  840
acctccttc  cctcaagaa  accttttta  atctccatt  cttattcca  ttggatttc  900
tctagcaag  aagcccatt  atgtgtatg  ggtcaactg  ttatagtct  ttcacactg  960
agctttggg  aaactccat  ccttggttt  tgttgtctc  accttcctg  tgtgcagtt  1020
ctgctgtag  aaagtatca  tagcttcat  tcatataaa  acgagtaac  tccagacac  1080
tgtgtagag  actgacagc  catttggta  ttaagtaat  tgaaccagt  ctgcaagtg  1140
ctgtgtttt  tattactgt  aagatatgg  aatggtagt  cattacaat  taaagtgat  1200
gtaataata  cgtcttgat  tctacattc  ttttctgaa  tttcttggg  gtttccttt  1260
agaagcaac  tttccatgc  cttactaca  attcctttt  agtaggaat  cagaagtgt  1320
agattgaat  ggaaagcgc  taatgcatc  gggcttggg  gtcacagat  gaaatgtct  1380
ctgtgtcac  ttctggagg  tacatctgt  tgtgacaac  gggcgtttc  ttatgcatt  1440
ttcatttgc  gctgtttaa  ttgacaact  ccttcccaa  aaaaattca  ttacacctc  1500
tgccttcgt  gctctggta  tcactttac  ttgtgacag  agtagcatg  tgctgccag  1560
atacaagca  tgctttggg  aaattaaaa  gcatgtcct  tcttaatac  ctaggaagg  1620
gaaataaag  acacaagtc  aagtctaaa  tttagtact  ttccatgca  atttgtgca  1680
atgtgaggg  gtatccagt  tgtccagtg  ttgttcttt  gagagttgg  ccactatat  1740
gtgtgtttg  taatcattg  ctgtagtcc  aaaaaagcc  tgtgaaaat  ttatgccct  1800
tgtaacagc  gagtaacat  aaataaaac  acattttat  aaaccattt  ttatggctt  1860
gtaacagtt  catacccat  ttttaagaa  agacaaatt  actactttt  gaagtttgt  1920
gctatttct  tttatgtaa  atataatgg  gatatccat  tttctgcat  gtggtacac  1980
tgtctaggg  gcctggcac  gtaaaattg  actatattt  tccagatag  ctcatgggt  2040
gtcttcctc  gatgtaatg  taactggtt  ggtgtcatg  gtaataaag  gaacatttg  2099



<210> 1818
<211> 245
<212> PRT
<213> Rattus norvegicus
<308> P35216
<400> 1818

Met Glu Lys Thr Glu Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
  1               5                  10                  15
Glu Arg Tyr Asp Asp Met Ala Thr Cys Met Lys Ala Val Thr Glu Gln 
             20                  25                  30
Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
         35                  40                  45
Lys Asn Val Val Gly Gly Arg Arg Ser Ala Trp Arg Val Ile Ser Ser 
     50                  55                  60
Ile Glu Gln Lys Thr Asp Thr Ser Asp Lys Lys Leu Gln Leu Ile Lys 
 65                  70                  75                  80
Asp Tyr Arg Glu Lys Val Glu Ser Glu Leu Arg Ser Ile Cys Thr Thr 
                 85                  90                  95
Val Leu Glu Leu Leu Asp Lys Tyr Leu Ile Ala Asn Ala Thr Asn Pro 
             100                105                110
Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Phe Arg Tyr 
         115                120                125
Leu Ala Glu Val Ala Cys Gly Asp Asp Arg Lys Gln Thr Ile Glu Asn 
     130                135                140
Ser Gln Gly Ala Tyr Gln Glu Ala Phe Asp Ile Ser Lys Lys Glu Met 
 145                150                155                160
Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                 165                170                175
Phe Tyr Tyr Glu Ile Leu Asn Asn Pro Glu Leu Ala Cys Thr Leu Ala 
             180                185                190
Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Asn Glu 
         195                200                205
Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
     210                215                220
Leu Thr Leu Trp Thr Ser Asp Ser Ala Gly Glu Glu Cys Asp Ala Ala 
 225                230                235                240
Glu Gly Ala Glu Asn 
                 245



<210> 1819
<211> 2166
<212> DNA
<213> Homo sapiens
<308> NM_006826
<400> 1819

gtggtggga  tcgcgtcgc  gccgcggag  cgtgaagct  tcgaggctc  tcccgctgc  60
ggtcggcgc  cgccctcgc  ctcctcgcc  tccgccccg  ccccggccc  gcgcccgcc  120
tggagaaga  tgagctgat  cagaaggcc  agctggccg  gcaggccga  cgctacgac  180
acatggcca  ctgcatgaa  gcagtgacc  agcagggcg  cgagctgtc  aacgaggag  240
gcaacctgc  ctccgtggc  tacaagaac  tggtcgggg  ccgcaggtc  gcctggagg  300
tcatctcta  catcgagca  aagaccgac  cctccgaca  gaagttgca  ctgattaag  360
actatcggg  gaaagtgga  tccgagctg  gatccatct  caccacggt  ctggaattg  420
tggataaat  tttaatagc  aatgcaact  atccagaga  taaggtctt  tatctgaaa  480
tgaagggtg  ttacttccg  taccttgct  aagttgcgt  tggtgatga  cgaaaacaa  540
cgatagata  ttcccaagg  gcttaccaa  aggcatttg  tataagcaa  aaagagatg  600
aacccacac  cccaatccg  ctggggctt  ctcttaact  ttctgtatt  tactatgag  660
ttcttaata  cccagagct  gcctgcacg  tggctaaaa  ggcttttga  gaggccatt  720
ctgaacttg  tacactgaa  gaagactca  acaaagaca  caccctcat  atgcagttg  780
ttagagaca  cctaacact  tggacatca  acagtgcag  agaagaatg  gatgcggca  840
aaggggctg  aaactaaat  catacaggg  gtcatcctt  tttccttca  gaaaccttt  900
tacacatct  cattcctta  tccacttgg  tttcctata  caaagaaac  cattcatgt  960
tatggaatc  actgtttat  gtcttttca  actgcagct  tgggaaaac  tcattcctt  1020
atttgtgtt  gtcttggcc  tcctggtgt  cagtactgc  gtagaaaag  attaatagc  1080
tcatttcat  taaacataa  taactccca  acacttatg  agaggacta  aaatgtatc  1140
ggtatttaa  taatctgaa  cagttctgc  agtgactgt  ttttgtatt  ctgtgaaaa  1200
aagaaaatg  agttaatta  aatttaaag  gtattccac  taacttctt  atttctaca  1260
tccctccct  actcttcgg  ggtttcctt  cagtaagca  cttttccat  ctcttaatg  1320
attcctttt  agtaggaat  cggaagtat  agattgaat  gaaaagcac  tgccatctc  1380
gtctagggg  cacaaattg  aatggctcc  gtatcacat  cggaggtct  gtgtatctg  1440
ggcaacagg  agtttcctt  ttcactctt  atttgctgc  gtttaagtt  ccaacctcc  1500
ctcccaata  aaattcact  acacctcct  cctttgtag  tctggtatt  actttacta  1560
gtgatagaa  tagcatgtt  ctgccagaa  acaagcatt  cttttggca  attaaagtg  1620
atgtcattt  ttaatacac  agaaagggg  aataaatta  agtacacaa  tccaagtct  1680
aaactttag  acttttcca  gcagatttg  gcacatgtg  gagggtgtc  agtttgtct  1740
gtgattgtt  tttagagag  tggaccact  ttgtgtgtt  ctaatcatt  actgtagtc  1800
caaaaaagc  ttgtgaaaa  gttatgccc  atgtaacag  agagtaaca  aaaataaaa  1860
tacatttta  aaaccattt  ctatggctt  gtaacaatt  catacccat  ttttaaggg  1920
caggtgaat  tactacttt  taaagttta  tgatacttc  cttttatgt  aaatgtagt  1980
gtgatacct  tatttccac  ttgtgcatt  tgacacact  gtctaggga  gcctggaag  2040
gtataaaat  ggactgcat  tcttagagt  ttttactat  gatcagtct  atgggccat  2100
tcttcctca  atgtaaatg  tatctggtt  agtgttata  ggaataaag  ggacatttt  2160
aaacta  2166



<210> 1820
<211> 245
<212> PRT
<213> Homo sapiens
<308> P27348
<400> 1820

Met Glu Lys Thr Glu Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
  1               5                  10                  15
Glu Arg Tyr Asp Asp Met Ala Thr Cys Met Lys Ala Val Thr Glu Gln 
             20                  25                  30
Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
         35                  40                  45
Lys Asn Val Val Gly Gly Arg Arg Ser Ala Trp Arg Val Ile Ser Ser 
     50                  55                  60
Ile Glu Gln Lys Thr Asp Thr Ser Asp Lys Lys Leu Gln Leu Ile Lys 
 65                  70                  75                  80
Asp Tyr Arg Glu Lys Val Glu Ser Glu Leu Arg Ser Ile Cys Thr Thr 
                 85                  90                  95
Val Leu Glu Leu Leu Asp Lys Tyr Leu Ile Ala Asn Ala Thr Asn Pro 
             100                105                110
Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Phe Arg Tyr 
         115                120                125
Leu Ala Glu Val Ala Cys Gly Asp Asp Arg Lys Gln Thr Ile Asp Asn 
     130                135                140
Ser Gln Gly Ala Tyr Gln Glu Ala Phe Asp Ile Ser Lys Lys Glu Met 
 145                150                155                160
Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                 165                170                175
Phe Tyr Tyr Glu Ile Leu Asn Asn Pro Glu Leu Ala Cys Thr Leu Ala 
             180                185                190
Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Asn Glu 
         195                200                205
Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
     210                215                220
Leu Thr Leu Trp Thr Ser Asp Ser Ala Gly Glu Glu Cys Asp Ala Ala 
 225                230                235                240
Glu Gly Ala Glu Asn 
                 245



<210> 1821
<211> 2563
<212> DNA
<213> Rattus norvegicus
<308> D17711
<400> 1821

attggtgga  ccatttagt  caagaaaat  gagaccgaa  agccagaag  aaccttccc  60
aacaccgaa  ccaatggtg  atttggtaa  cgccctgca  aagatatgg  agaggaaca  120
gcctttaaa  gatctagaa  tactgatga  atggttgaa  tgcgcattt  gcttcagag  180
aagaatgct  gggcagtga  tggaaaagg  ggcaagaat  ttaaggctc  ccgtacaga  240
tacaatgcc  gtgtttcag  cccagacag  agtggcccc  agcgcatac  gagtatcag  300
gctgatatt  agacgattg  agaaattct  aagaaaatc  tccctactt  ggaagaggg  360
ctgcagttg  catcaccca  tgcaaccag  cagctcccg  tcgaatctg  tgctgtgga  420
tgcttaaat  accagcatt  taaagggag  gacttcgac  gcgagctga  actgttgat  480
catcaaagt  tggccggag  aattattgg  gttaaaggt  ctaaaatca  agaacttcg  540
gaaaacact  agacaacaa  caagctttt  caggaatgc  gccctcatt  tactgacag  600
gttgttctt  ttggaggaa  gcccgatag  gttgtagaa  gcatcaaga  catccttga  660
cttatatct  agtctccca  caaaggacg  gcacaacct  atgatccca  cttctatga  720
gaaacctat  attatggtg  ttttacaat  atgtttgat  accgccgag  acgacctgt  780
ggattcccc  tgcggggaa  aggtggttt  gacagaatg  ctcctggtc  gggtgggcg  840
cccatgcct  cttctagaa  agattatga  gatatgagc  ctcgtcgag  accaccacc  900
ccaccacct  gtcgaggtg  acggggtgg  agcagagct  ggaatcttc  tcttcctcc  960
ccaccacca  ccagagggg  agatctcat  gcttacgac  gaagaggac  gcctggaga  1020
cgctatgat  gcatggttg  gttcagtgc  gatgaaact  gggactctg  aattgacac  1080
tggagccca  cagaatggc  aatggctta  gaaccacag  gtggttctg  atatgatta  1140
tcttatgca  ggggccgtg  ctcgtatgg  gatcttggc  gacctatta  cactacaca  1200
gtaactatt  ccaaagatt  ggctggatc  attattggc  aaggtggtc  gcggattaa  1260
caaattcgt  atgagtctg  agcatctat  aaaattgat  aacctttag  aggatctga  1320
gatcggatc  ttaccatta  gggaacaca  gaccagata  agaacgcac  gtatttgct  1380
cagaacagt  tgaagcagt  ttctggaaa  tttttctaa  actagtgaa  aactgaagg  1440
gtcctgcat  ttttttttt  tatctgctt  tgtttaaaa  gccaacatt  ctctgcttc  1500
taggtgttc  gcatttgag  tgtagtgaa  tctttgctg  tcaccagat  taatgtttt  1560
gttccttac  aacagggtt  gggggaggg  atgcaaaaa  actaacatt  aaattttga  1620
acagcagca  agtgagtga  ttttatttt  tgttcattg  tggtggttt  aaaaattcc  1680
cccgtgtaa  tattgtgaa  accttgctt  gtggtcact  taacattgg  gggtgggac  1740
gggaggaaa  taatagtcc  catgtccct  gcatttgtt  agagcagtg  gcagaatgt  1800
atgctcttt  gtaagaaac  ttttatgat  tttaaaata  atttagtga  tctattttt  1860
gtggtcttt  ttttttttt  taaagacaa  ttcaaatgg  ggttgaatt  tccagccca  1920
ccctaaact  aacactaag  ttgattttc  gcagctcct  tgttggata  aagtgcacc  1980
cttggatat  gacaaacac  ttggcaaat  tcagtttgg  tgatttctt  atggttgga  2040
agacttggc  tgataaatt  ccatcacat  ttcatgctt  taataagct  gggattttg  2100
ttgtttttg  aaatgtttg  cactacttt  caacagttt  ctgttagtc  tggggaact  2160
cggtgggga  caatactac  agagtaagc  tctgagtat  tgccagaag  ctggtgggc  2220
atgagcttt  ttaaccaga  taacacttg  ttatggaag  ggctgatgc  gaataaatc  2280
tggttattt  tgttagata  tttctcacc  atagactta  gctgtcaac  gctagcgtc  2340
tgttagttg  actttgtaa  aatatatat  tacttgttt  tccattgta  gcacaatga  2400
agaaaaaag  tgtaccatt  ctctgttgt  tgttgaatt  tgtaggaaa  gtttgtgaa  2460
gattcaaaa  aaatggaaa  gttcctgtg  atgttttgt  tagtaactt  gcatctgta  2520
tgatagttc  aaatccaca  ctaaataaa  cttcatgat  tta  2563



<210> 1822
<211> 463
<212> PRT
<213> Rattus norvegicus
<308> Q07244
<400> 1822

Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn 
  1               5                  10                  15
Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala 
             20                  25                  30
Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu 
         35                  40                  45
Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn 
     50                  55                  60
Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp 
 65                  70                  75                  80
Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr 
                 85                  90                  95
Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu 
             100                105                110
Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp 
         115                120                125
Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp 
     130                135                140
Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile 
 145                150                155                160
Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr 
                 165                170                175
Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val 
             180                185                190
Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile 
         195                200                205
Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro 
     210                215                220
Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr 
 225                230                235                240
Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg 
                 245                250                255
Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro 
             260                265                270
Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly 
         275                280                285
Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala 
     290                295                300
Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu 
 305                310                315                320
Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met 
                 325                330                335
Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp 
             340                345                350
Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly 
         355                360                365
Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly 
     370                375                380
Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly 
 385                390                395                400
Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu 
                 405                410                415
Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp 
             420                425                430
Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln 
         435                440                445
Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ser Gly Lys Phe Phe 
     450                455                460



<210> 1824
<211> 1465
<212> PRT
<213> Homo sapiens
<308> P54296
<400> 1824

Met Ser Leu Val Thr Val Pro Phe Tyr Gln Lys Arg His Arg His Phe 
  1               5                  10                  15
Asp Gln Ser Tyr Arg Asn Ile Gln Thr Arg Tyr Leu Leu Asp Glu Tyr 
             20                  25                  30
Ala Ser Lys Lys Arg Ala Ser Thr Gln Ala Ser Ser Gln Lys Ser Leu 
         35                  40                  45
Ser Gln Arg Ser Ser Ser Gln Arg Ala Ser Ser Gln Thr Ser Leu Gly 
     50                  55                  60
Gly Thr Ile Cys Arg Val Cys Ala Lys Arg Val Ser Thr Gln Glu Asp 
 65                  70                  75                  80
Glu Glu Gln Glu Asn Arg Ser Arg Tyr Gln Ser Leu Val Ala Ala Tyr 
                 85                  90                  95
Gly Glu Ala Lys Arg His Gly Phe Leu Ser Glu Leu Ala His Leu Glu 
             100                105                110
Glu Asp Val His Leu Ala Arg Ser Gln Ala Arg Asp Lys Leu Asp Lys 
         115                120                125
Tyr Ala Ile Gln Gln Met Met Glu Asp Lys Leu Ala Trp Glu Arg His 
     130                135                140
Thr Phe Glu Glu Arg Ile Ser Arg Ala Pro Glu Ile Leu Val Arg Leu 
 145                150                155                160
Arg Ser His Thr Val Trp Glu Arg Met Ser Val Lys Leu Cys Phe Thr 
                 165                170                175
Val Gln Gly Phe Pro Thr Pro Val Val Gln Trp Tyr Lys Asp Gly Ser 
             180                185                190
Leu Ile Cys Gln Ala Ala Glu Pro Gly Lys Tyr Arg Ile Glu Ser Asn 
         195                200                205
Tyr Gly Val His Thr Leu Glu Ile Asn Arg Ala Asp Phe Asp Asp Thr 
     210                215                220
Ala Thr Tyr Ser Ala Val Ala Thr Asn Ala His Gly Gln Val Ser Thr 
 225                230                235                240
Asn Ala Ala Val Val Val Arg Arg Phe Arg Gly Asp Glu Glu Pro Phe 
                 245                250                255
Arg Ser Val Gly Leu Pro Ile Gly Leu Pro Leu Ser Ser Met Ile Pro 
             260                265                270
Tyr Thr His Phe Asp Val Gln Phe Leu Glu Lys Phe Gly Val Thr Phe 
         275                280                285
Arg Arg Glu Gly Glu Thr Val Thr Leu Lys Cys Thr Met Leu Val Thr 
     290                295                300
Pro Asp Leu Lys Arg Val Gln Pro Arg Ala Glu Trp Tyr Arg Asp Asp 
 305                310                315                320
Leu Leu Leu Lys Glu Ser Lys Trp Thr Lys Met Phe Phe Gly Glu Gly 
                 325                330                335
Gln Ala Ser Leu Ser Phe Ser His Leu His Lys Asp Asp Glu Gly Leu 
             340                345                350
Tyr Thr Leu Arg Ile Val Ser Arg Gly Gly Val Thr Asp His Ser Ala 
         355                360                365
Phe Leu Phe Val Arg Asp Ala Asp Pro Leu Val Thr Gly Ala Pro Gly 
     370                375                380
Ala Pro Met Asp Leu Gln Cys His Asp Ala Asn Arg Asp Tyr Val Ile 
 385                390                395                400
Val Thr Trp Lys Pro Pro Asn Thr Thr Thr Glu Ser Pro Val Met Gly 
                 405                410                415
Tyr Phe Val Asp Arg Cys Glu Val Gly Thr Asn Asn Trp Val Gln Cys 
             420                425                430
Asn Asp Ala Pro Val Lys Ile Cys Lys Tyr Pro Val Thr Gly Leu Phe 
         435                440                445
Glu Gly Arg Ser Tyr Ile Phe Arg Val Arg Ala Val Asn Ser Ala Gly 
     450                455                460
Ile Ser Arg Pro Ser Arg Val Ser Asp Ala Val Ala Ala Leu Asp Pro 
 465                470                475                480
Leu Asp Leu Arg Arg Leu Gln Ala Val His Leu Glu Gly Glu Lys Glu 
                 485                490                495
Ile Ala Ile Tyr Gln Asp Asp Leu Glu Gly Asp Ala Gln Val Pro Gly 
             500                505                510
Pro Pro Thr Gly Val His Ala Ser Glu Ile Ser Arg Asn Tyr Val Val 
         515                520                525
Leu Ser Trp Glu Pro Pro Thr Pro Arg Gly Lys Asp Pro Leu Met Tyr 
     530                535                540
Phe Ile Glu Lys Ser Val Val Gly Ser Gly Thr Trp Gln Arg Val Asn 
 545                550                555                560
Ala Gln Thr Ala Val Arg Ser Pro Arg Tyr Ala Val Phe Asp Leu Met 
                 565                570                575
Glu Gly Lys Ser Tyr Val Phe Arg Val Leu Ser Ala Asn Arg His Gly 
             580                585                590
Leu Ser Glu Pro Ser Glu Ile Thr Ser Pro Ile Gln Ala Gln Asp Val 
         595                600                605
Thr Val Val Pro Ser Ala Pro Gly Arg Val Leu Ala Ser Arg Asn Thr 
     610                615                620
Lys Thr Ser Val Val Val Gln Trp Asp Arg Pro Lys His Glu Glu Asp 
 625                630                635                640
Leu Leu Gly Tyr Tyr Val Asp Cys Cys Val Ala Gly Thr Asn Leu Trp 
                 645                650                655
Glu Pro Cys Asn His Lys Pro Ile Gly Tyr Asn Arg Phe Val Val His 
             660                665                670
Gly Leu Thr Thr Gly Glu Gln Tyr Ile Phe Arg Val Lys Ala Val Asn 
         675                680                685
Ala Val Gly Met Ser Glu Asn Ser Gln Glu Ser Asp Val Ile Lys Val 
     690                695                700
Gln Ala Ala Leu Thr Val Pro Ser His Pro Tyr Gly Ile Thr Leu Leu 
 705                710                715                720
Asn Cys Asp Gly His Ser Met Thr Leu Gly Trp Lys Val Pro Lys Phe 
                 725                730                735
Ser Gly Gly Ser Pro Ile Leu Gly Tyr Tyr Leu Asp Lys Arg Glu Val 
             740                745                750
His His Lys Asn Trp His Glu Val Asn Ser Ser Pro Ser Lys Pro Thr 
         755                760                765
Ile Leu Thr Val Asp Gly Leu Thr Glu Gly Ser Leu Tyr Glu Phe Lys 
     770                775                780
Ile Ala Ala Val Asn Leu Ala Gly Ile Gly Glu Pro Ser Asp Pro Ser 
 785                790                795                800
Glu His Phe Lys Cys Glu Ala Trp Thr Met Pro Glu Pro Gly Pro Ala 
                 805                810                815
Tyr Asp Leu Thr Phe Cys Glu Val Arg Asp Thr Ser Leu Val Met Leu 
             820                825                830
Trp Lys Ala Pro Val Tyr Ser Gly Ser Ser Pro Val Ser Gly Tyr Phe 
         835                840                845
Val Asp Phe Arg Glu Glu Asp Ala Gly Glu Trp Ile Thr Val Asp Gln 
     850                855                860
Thr Thr Thr Ala Ser Arg Tyr Leu Lys Val Ser Asp Leu Gln Gln Gly 
 865                870                875                880
Lys Thr Tyr Val Phe Arg Val Arg Ala Val Asn Ala Asn Gly Val Gly 
                 885                890                895
Lys Pro Ser Asp Thr Ser Glu Pro Val Leu Val Glu Ala Arg Pro Gly 
             900                905                910
Thr Lys Glu Ile Ser Ala Gly Val Asp Glu Gln Gly Asn Ile Tyr Leu 
         915                920                925
Gly Phe Asp Cys Gln Glu Met Thr Asp Ala Ser Gln Phe Thr Trp Cys 
     930                935                940
Lys Ser Tyr Glu Glu Ile Ser Asp Asp Glu Arg Phe Lys Ile Glu Thr 
 945                950                955                960
Val Gly Asp His Ser Lys Leu Tyr Leu Lys Asn Pro Asp Lys Glu Asp 
                 965                970                975
Leu Gly Thr Tyr Ser Val Ser Val Ser Asp Thr Asp Gly Val Ser Ser 
             980                985                990
Ser Phe Val Leu Asp Pro Glu Glu Leu Glu Arg Leu Met Ala Leu Ser 
         995                1000                1005
Asn Glu Ile Lys Asn Pro Thr Ile Pro Leu Lys Ser Glu Leu Ala Tyr 
     1010                1015                1020
Glu Ile Phe Asp Lys Gly Arg Val Arg Phe Trp Leu Gln Ala Glu His 
 1025                1030                1035                1040
Leu Ser Pro Asp Ala Ser Tyr Arg Phe Ile Ile Asn Asp Arg Glu Val 
                 1045                1050                1055
Ser Asp Ser Glu Ile His Arg Ile Lys Cys Asp Lys Ala Thr Gly Ile 
             1060                1065                1070
Ile Glu Met Val Met Asp Arg Phe Ser Ile Glu Asn Glu Gly Thr Tyr 
         1075                1080                1085
Thr Val Gln Ile His Asp Gly Lys Ala Lys Ser Gln Ser Ser Leu Val 
     1090                1095                1100
Leu Ile Gly Asp Ala Phe Lys Thr Val Leu Glu Glu Ala Glu Phe Gln 
 1105                1110                1115                1120
Arg Lys Glu Phe Leu Arg Lys Gln Gly Pro His Phe Ala Glu Tyr Leu 
                 1125                1130                1135
His Trp Asp Val Thr Glu Glu Cys Glu Val Arg Leu Val Cys Lys Val 
             1140                1145                1150
Ala Asn Thr Lys Lys Glu Thr Val Phe Lys Trp Leu Lys Asp Asp Ala 
         1155                1160                1165
Leu Tyr Glu Thr Glu Thr Leu Pro Asn Leu Glu Arg Gly Ile Cys Glu 
     1170                1175                1180
Leu Leu Ile Pro Lys Leu Ser Lys Lys Asp His Gly Glu Tyr Lys Ala 
 1185                1190                1195                1200
Thr Leu Lys Asp Asp Arg Gly Gln Asp Val Ser Ile Leu Glu Ile Ala 
                 1205                1210                1215
Gly Lys Val Tyr Asp Asp Met Ile Leu Ala Met Ser Arg Val Cys Gly 
             1220                1225                1230
Lys Ser Ala Ser Pro Leu Lys Val Leu Cys Thr Pro Glu Gly Ile Arg 
         1235                1240                1245
Leu Gln Cys Phe Met Lys Tyr Phe Thr Asp Glu Met Lys Val Asn Trp 
     1250                1255                1260
Cys His Lys Asp Ala Lys Ile Ser Ser Ser Glu His Met Arg Ile Gly 
 1265                1270                1275                1280
Gly Ser Glu Glu Met Ala Trp Leu Gln Ile Cys Glu Pro Thr Glu Lys 
                 1285                1290                1295
Asp Lys Gly Lys Tyr Thr Phe Glu Ile Phe Asp Gly Lys Asp Asn His 
             1300                1305                1310
Gln Arg Ser Leu Asp Leu Ser Gly Gln Ala Phe Asp Glu Ala Phe Ala 
         1315                1320                1325
Glu Phe Gln Gln Phe Lys Ala Ala Ala Phe Ala Glu Lys Asn Arg Gly 
     1330                1335                1340
Arg Leu Ile Gly Gly Leu Pro Asp Val Val Thr Ile Met Glu Gly Lys 
 1345                1350                1355                1360
Thr Leu Asn Leu Thr Cys Thr Val Phe Gly Asn Pro Asp Pro Glu Val 
                 1365                1370                1375
Ile Trp Phe Lys Asn Asp Gln Asp Ile Gln Leu Ser Glu His Phe Ser 
             1380                1385                1390
Val Lys Val Glu Gln Ala Lys Tyr Val Ser Met Thr Ile Lys Gly Val 
         1395                1400                1405
Thr Ser Glu Asp Ser Gly Lys Tyr Ser Ile Asn Ile Lys Asn Lys Tyr 
     1410                1415                1420
Gly Gly Glu Lys Ile Asp Val Thr Val Ser Val Tyr Lys His Gly Glu 
 1425                1430                1435                1440
Lys Ile Pro Asp Met Ala Pro Pro Gln Gln Ala Lys Pro Lys Leu Ile 
                 1445                1450                1455
Pro Ala Ser Ala Ser Ala Ala Gly Gln 
             1460                1465



<210> 1825
<211> 2563
<212> DNA
<213> Rattus norvegicus
<308> D17711
<400> 1825

attggtgga  ccatttagt  caagaaaat  gagaccgaa  agccagaag  aaccttccc  60
aacaccgaa  ccaatggtg  atttggtaa  cgccctgca  aagatatgg  agaggaaca  120
gcctttaaa  gatctagaa  tactgatga  atggttgaa  tgcgcattt  gcttcagag  180
aagaatgct  gggcagtga  tggaaaagg  ggcaagaat  ttaaggctc  ccgtacaga  240
tacaatgcc  gtgtttcag  cccagacag  agtggcccc  agcgcatac  gagtatcag  300
gctgatatt  agacgattg  agaaattct  aagaaaatc  tccctactt  ggaagaggg  360
ctgcagttg  catcaccca  tgcaaccag  cagctcccg  tcgaatctg  tgctgtgga  420
tgcttaaat  accagcatt  taaagggag  gacttcgac  gcgagctga  actgttgat  480
catcaaagt  tggccggag  aattattgg  gttaaaggt  ctaaaatca  agaacttcg  540
gaaaacact  agacaacaa  caagctttt  caggaatgc  gccctcatt  tactgacag  600
gttgttctt  ttggaggaa  gcccgatag  gttgtagaa  gcatcaaga  catccttga  660
cttatatct  agtctccca  caaaggacg  gcacaacct  atgatccca  cttctatga  720
gaaacctat  attatggtg  ttttacaat  atgtttgat  accgccgag  acgacctgt  780
ggattcccc  tgcggggaa  aggtggttt  gacagaatg  ctcctggtc  gggtgggcg  840
cccatgcct  cttctagaa  agattatga  gatatgagc  ctcgtcgag  accaccacc  900
ccaccacct  gtcgaggtg  acggggtgg  agcagagct  ggaatcttc  tcttcctcc  960
ccaccacca  ccagagggg  agatctcat  gcttacgac  gaagaggac  gcctggaga  1020
cgctatgat  gcatggttg  gttcagtgc  gatgaaact  gggactctg  aattgacac  1080
tggagccca  cagaatggc  aatggctta  gaaccacag  gtggttctg  atatgatta  1140
tcttatgca  ggggccgtg  ctcgtatgg  gatcttggc  gacctatta  cactacaca  1200
gtaactatt  ccaaagatt  ggctggatc  attattggc  aaggtggtc  gcggattaa  1260
caaattcgt  atgagtctg  agcatctat  aaaattgat  aacctttag  aggatctga  1320
gatcggatc  ttaccatta  gggaacaca  gaccagata  agaacgcac  gtatttgct  1380
cagaacagt  tgaagcagt  ttctggaaa  tttttctaa  actagtgaa  aactgaagg  1440
gtcctgcat  ttttttttt  tatctgctt  tgtttaaaa  gccaacatt  ctctgcttc  1500
taggtgttc  gcatttgag  tgtagtgaa  tctttgctg  tcaccagat  taatgtttt  1560
gttccttac  aacagggtt  gggggaggg  atgcaaaaa  actaacatt  aaattttga  1620
acagcagca  agtgagtga  ttttatttt  tgttcattg  tggtggttt  aaaaattcc  1680
cccgtgtaa  tattgtgaa  accttgctt  gtggtcact  taacattgg  gggtgggac  1740
gggaggaaa  taatagtcc  catgtccct  gcatttgtt  agagcagtg  gcagaatgt  1800
atgctcttt  gtaagaaac  ttttatgat  tttaaaata  atttagtga  tctattttt  1860
gtggtcttt  ttttttttt  taaagacaa  ttcaaatgg  ggttgaatt  tccagccca  1920
ccctaaact  aacactaag  ttgattttc  gcagctcct  tgttggata  aagtgcacc  1980
cttggatat  gacaaacac  ttggcaaat  tcagtttgg  tgatttctt  atggttgga  2040
agacttggc  tgataaatt  ccatcacat  ttcatgctt  taataagct  gggattttg  2100
ttgtttttg  aaatgtttg  cactacttt  caacagttt  ctgttagtc  tggggaact  2160
cggtgggga  caatactac  agagtaagc  tctgagtat  tgccagaag  ctggtgggc  2220
atgagcttt  ttaaccaga  taacacttg  ttatggaag  ggctgatgc  gaataaatc  2280
tggttattt  tgttagata  tttctcacc  atagactta  gctgtcaac  gctagcgtc  2340
tgttagttg  actttgtaa  aatatatat  tacttgttt  tccattgta  gcacaatga  2400
agaaaaaag  tgtaccatt  ctctgttgt  tgttgaatt  tgtaggaaa  gtttgtgaa  2460
gattcaaaa  aaatggaaa  gttcctgtg  atgttttgt  tagtaactt  gcatctgta  2520
tgatagttc  aaatccaca  ctaaataaa  cttcatgat  tta  2563



<210> 1826
<211> 463
<212> PRT
<213> Rattus norvegicus
<308> Q07244
<400> 1826

Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn 
  1               5                  10                  15
Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala 
             20                  25                  30
Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu 
         35                  40                  45
Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn 
     50                  55                  60
Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp 
 65                  70                  75                  80
Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr 
                 85                  90                  95
Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu 
             100                105                110
Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp 
         115                120                125
Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp 
     130                135                140
Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile 
 145                150                155                160
Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr 
                 165                170                175
Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val 
             180                185                190
Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile 
         195                200                205
Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro 
     210                215                220
Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr 
 225                230                235                240
Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg 
                 245                250                255
Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro 
             260                265                270
Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly 
         275                280                285
Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala 
     290                295                300
Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu 
 305                310                315                320
Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met 
                 325                330                335
Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp 
             340                345                350
Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly 
         355                360                365
Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly 
     370                375                380
Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly 
 385                390                395                400
Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu 
                 405                410                415
Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp 
             420                425                430
Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln 
         435                440                445
Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ser Gly Lys Phe Phe 
     450                455                460



<210> 1828
<211> 1465
<212> PRT
<213> Homo sapiens
<308> P54296
<400> 1828

Met Ser Leu Val Thr Val Pro Phe Tyr Gln Lys Arg His Arg His Phe 
  1               5                  10                  15
Asp Gln Ser Tyr Arg Asn Ile Gln Thr Arg Tyr Leu Leu Asp Glu Tyr 
             20                  25                  30
Ala Ser Lys Lys Arg Ala Ser Thr Gln Ala Ser Ser Gln Lys Ser Leu 
         35                  40                  45
Ser Gln Arg Ser Ser Ser Gln Arg Ala Ser Ser Gln Thr Ser Leu Gly 
     50                  55                  60
Gly Thr Ile Cys Arg Val Cys Ala Lys Arg Val Ser Thr Gln Glu Asp 
 65                  70                  75                  80
Glu Glu Gln Glu Asn Arg Ser Arg Tyr Gln Ser Leu Val Ala Ala Tyr 
                 85                  90                  95
Gly Glu Ala Lys Arg His Gly Phe Leu Ser Glu Leu Ala His Leu Glu 
             100                105                110
Glu Asp Val His Leu Ala Arg Ser Gln Ala Arg Asp Lys Leu Asp Lys 
         115                120                125
Tyr Ala Ile Gln Gln Met Met Glu Asp Lys Leu Ala Trp Glu Arg His 
     130                135                140
Thr Phe Glu Glu Arg Ile Ser Arg Ala Pro Glu Ile Leu Val Arg Leu 
 145                150                155                160
Arg Ser His Thr Val Trp Glu Arg Met Ser Val Lys Leu Cys Phe Thr 
                 165                170                175
Val Gln Gly Phe Pro Thr Pro Val Val Gln Trp Tyr Lys Asp Gly Ser 
             180                185                190
Leu Ile Cys Gln Ala Ala Glu Pro Gly Lys Tyr Arg Ile Glu Ser Asn 
         195                200                205
Tyr Gly Val His Thr Leu Glu Ile Asn Arg Ala Asp Phe Asp Asp Thr 
     210                215                220
Ala Thr Tyr Ser Ala Val Ala Thr Asn Ala His Gly Gln Val Ser Thr 
 225                230                235                240
Asn Ala Ala Val Val Val Arg Arg Phe Arg Gly Asp Glu Glu Pro Phe 
                 245                250                255
Arg Ser Val Gly Leu Pro Ile Gly Leu Pro Leu Ser Ser Met Ile Pro 
             260                265                270
Tyr Thr His Phe Asp Val Gln Phe Leu Glu Lys Phe Gly Val Thr Phe 
         275                280                285
Arg Arg Glu Gly Glu Thr Val Thr Leu Lys Cys Thr Met Leu Val Thr 
     290                295                300
Pro Asp Leu Lys Arg Val Gln Pro Arg Ala Glu Trp Tyr Arg Asp Asp 
 305                310                315                320
Leu Leu Leu Lys Glu Ser Lys Trp Thr Lys Met Phe Phe Gly Glu Gly 
                 325                330                335
Gln Ala Ser Leu Ser Phe Ser His Leu His Lys Asp Asp Glu Gly Leu 
             340                345                350
Tyr Thr Leu Arg Ile Val Ser Arg Gly Gly Val Thr Asp His Ser Ala 
         355                360                365
Phe Leu Phe Val Arg Asp Ala Asp Pro Leu Val Thr Gly Ala Pro Gly 
     370                375                380
Ala Pro Met Asp Leu Gln Cys His Asp Ala Asn Arg Asp Tyr Val Ile 
 385                390                395                400
Val Thr Trp Lys Pro Pro Asn Thr Thr Thr Glu Ser Pro Val Met Gly 
                 405                410                415
Tyr Phe Val Asp Arg Cys Glu Val Gly Thr Asn Asn Trp Val Gln Cys 
             420                425                430
Asn Asp Ala Pro Val Lys Ile Cys Lys Tyr Pro Val Thr Gly Leu Phe 
         435                440                445
Glu Gly Arg Ser Tyr Ile Phe Arg Val Arg Ala Val Asn Ser Ala Gly 
     450                455                460
Ile Ser Arg Pro Ser Arg Val Ser Asp Ala Val Ala Ala Leu Asp Pro 
 465                470                475                480
Leu Asp Leu Arg Arg Leu Gln Ala Val His Leu Glu Gly Glu Lys Glu 
                 485                490                495
Ile Ala Ile Tyr Gln Asp Asp Leu Glu Gly Asp Ala Gln Val Pro Gly 
             500                505                510
Pro Pro Thr Gly Val His Ala Ser Glu Ile Ser Arg Asn Tyr Val Val 
         515                520                525
Leu Ser Trp Glu Pro Pro Thr Pro Arg Gly Lys Asp Pro Leu Met Tyr 
     530                535                540
Phe Ile Glu Lys Ser Val Val Gly Ser Gly Thr Trp Gln Arg Val Asn 
 545                550                555                560
Ala Gln Thr Ala Val Arg Ser Pro Arg Tyr Ala Val Phe Asp Leu Met 
                 565                570                575
Glu Gly Lys Ser Tyr Val Phe Arg Val Leu Ser Ala Asn Arg His Gly 
             580                585                590
Leu Ser Glu Pro Ser Glu Ile Thr Ser Pro Ile Gln Ala Gln Asp Val 
         595                600                605
Thr Val Val Pro Ser Ala Pro Gly Arg Val Leu Ala Ser Arg Asn Thr 
     610                615                620
Lys Thr Ser Val Val Val Gln Trp Asp Arg Pro Lys His Glu Glu Asp 
 625                630                635                640
Leu Leu Gly Tyr Tyr Val Asp Cys Cys Val Ala Gly Thr Asn Leu Trp 
                 645                650                655
Glu Pro Cys Asn His Lys Pro Ile Gly Tyr Asn Arg Phe Val Val His 
             660                665                670
Gly Leu Thr Thr Gly Glu Gln Tyr Ile Phe Arg Val Lys Ala Val Asn 
         675                680                685
Ala Val Gly Met Ser Glu Asn Ser Gln Glu Ser Asp Val Ile Lys Val 
     690                695                700
Gln Ala Ala Leu Thr Val Pro Ser His Pro Tyr Gly Ile Thr Leu Leu 
 705                710                715                720
Asn Cys Asp Gly His Ser Met Thr Leu Gly Trp Lys Val Pro Lys Phe 
                 725                730                735
Ser Gly Gly Ser Pro Ile Leu Gly Tyr Tyr Leu Asp Lys Arg Glu Val 
             740                745                750
His His Lys Asn Trp His Glu Val Asn Ser Ser Pro Ser Lys Pro Thr 
         755                760                765
Ile Leu Thr Val Asp Gly Leu Thr Glu Gly Ser Leu Tyr Glu Phe Lys 
     770                775                780
Ile Ala Ala Val Asn Leu Ala Gly Ile Gly Glu Pro Ser Asp Pro Ser 
 785                790                795                800
Glu His Phe Lys Cys Glu Ala Trp Thr Met Pro Glu Pro Gly Pro Ala 
                 805                810                815
Tyr Asp Leu Thr Phe Cys Glu Val Arg Asp Thr Ser Leu Val Met Leu 
             820                825                830
Trp Lys Ala Pro Val Tyr Ser Gly Ser Ser Pro Val Ser Gly Tyr Phe 
         835                840                845
Val Asp Phe Arg Glu Glu Asp Ala Gly Glu Trp Ile Thr Val Asp Gln 
     850                855                860
Thr Thr Thr Ala Ser Arg Tyr Leu Lys Val Ser Asp Leu Gln Gln Gly 
 865                870                875                880
Lys Thr Tyr Val Phe Arg Val Arg Ala Val Asn Ala Asn Gly Val Gly 
                 885                890                895
Lys Pro Ser Asp Thr Ser Glu Pro Val Leu Val Glu Ala Arg Pro Gly 
             900                905                910
Thr Lys Glu Ile Ser Ala Gly Val Asp Glu Gln Gly Asn Ile Tyr Leu 
         915                920                925
Gly Phe Asp Cys Gln Glu Met Thr Asp Ala Ser Gln Phe Thr Trp Cys 
     930                935                940
Lys Ser Tyr Glu Glu Ile Ser Asp Asp Glu Arg Phe Lys Ile Glu Thr 
 945                950                955                960
Val Gly Asp His Ser Lys Leu Tyr Leu Lys Asn Pro Asp Lys Glu Asp 
                 965                970                975
Leu Gly Thr Tyr Ser Val Ser Val Ser Asp Thr Asp Gly Val Ser Ser 
             980                985                990
Ser Phe Val Leu Asp Pro Glu Glu Leu Glu Arg Leu Met Ala Leu Ser 
         995                1000                1005
Asn Glu Ile Lys Asn Pro Thr Ile Pro Leu Lys Ser Glu Leu Ala Tyr 
     1010                1015                1020
Glu Ile Phe Asp Lys Gly Arg Val Arg Phe Trp Leu Gln Ala Glu His 
 1025                1030                1035                1040
Leu Ser Pro Asp Ala Ser Tyr Arg Phe Ile Ile Asn Asp Arg Glu Val 
                 1045                1050                1055
Ser Asp Ser Glu Ile His Arg Ile Lys Cys Asp Lys Ala Thr Gly Ile 
             1060                1065                1070
Ile Glu Met Val Met Asp Arg Phe Ser Ile Glu Asn Glu Gly Thr Tyr 
         1075                1080                1085
Thr Val Gln Ile His Asp Gly Lys Ala Lys Ser Gln Ser Ser Leu Val 
     1090                1095                1100
Leu Ile Gly Asp Ala Phe Lys Thr Val Leu Glu Glu Ala Glu Phe Gln 
 1105                1110                1115                1120
Arg Lys Glu Phe Leu Arg Lys Gln Gly Pro His Phe Ala Glu Tyr Leu 
                 1125                1130                1135
His Trp Asp Val Thr Glu Glu Cys Glu Val Arg Leu Val Cys Lys Val 
             1140                1145                1150
Ala Asn Thr Lys Lys Glu Thr Val Phe Lys Trp Leu Lys Asp Asp Ala 
         1155                1160                1165
Leu Tyr Glu Thr Glu Thr Leu Pro Asn Leu Glu Arg Gly Ile Cys Glu 
     1170                1175                1180
Leu Leu Ile Pro Lys Leu Ser Lys Lys Asp His Gly Glu Tyr Lys Ala 
 1185                1190                1195                1200
Thr Leu Lys Asp Asp Arg Gly Gln Asp Val Ser Ile Leu Glu Ile Ala 
                 1205                1210                1215
Gly Lys Val Tyr Asp Asp Met Ile Leu Ala Met Ser Arg Val Cys Gly 
             1220                1225                1230
Lys Ser Ala Ser Pro Leu Lys Val Leu Cys Thr Pro Glu Gly Ile Arg 
         1235                1240                1245
Leu Gln Cys Phe Met Lys Tyr Phe Thr Asp Glu Met Lys Val Asn Trp 
     1250                1255                1260
Cys His Lys Asp Ala Lys Ile Ser Ser Ser Glu His Met Arg Ile Gly 
 1265                1270                1275                1280
Gly Ser Glu Glu Met Ala Trp Leu Gln Ile Cys Glu Pro Thr Glu Lys 
                 1285                1290                1295
Asp Lys Gly Lys Tyr Thr Phe Glu Ile Phe Asp Gly Lys Asp Asn His 
             1300                1305                1310
Gln Arg Ser Leu Asp Leu Ser Gly Gln Ala Phe Asp Glu Ala Phe Ala 
         1315                1320                1325
Glu Phe Gln Gln Phe Lys Ala Ala Ala Phe Ala Glu Lys Asn Arg Gly 
     1330                1335                1340
Arg Leu Ile Gly Gly Leu Pro Asp Val Val Thr Ile Met Glu Gly Lys 
 1345                1350                1355                1360
Thr Leu Asn Leu Thr Cys Thr Val Phe Gly Asn Pro Asp Pro Glu Val 
                 1365                1370                1375
Ile Trp Phe Lys Asn Asp Gln Asp Ile Gln Leu Ser Glu His Phe Ser 
             1380                1385                1390
Val Lys Val Glu Gln Ala Lys Tyr Val Ser Met Thr Ile Lys Gly Val 
         1395                1400                1405
Thr Ser Glu Asp Ser Gly Lys Tyr Ser Ile Asn Ile Lys Asn Lys Tyr 
     1410                1415                1420
Gly Gly Glu Lys Ile Asp Val Thr Val Ser Val Tyr Lys His Gly Glu 
 1425                1430                1435                1440
Lys Ile Pro Asp Met Ala Pro Pro Gln Gln Ala Lys Pro Lys Leu Ile 
                 1445                1450                1455
Pro Ala Ser Ala Ser Ala Ala Gly Gln 
             1460                1465



<210> 1829
<211> 2563
<212> DNA
<213> Rattus norvegicus
<308> D17711
<400> 1829

attggtgga  ccatttagt  caagaaaat  gagaccgaa  agccagaag  aaccttccc  60
aacaccgaa  ccaatggtg  atttggtaa  cgccctgca  aagatatgg  agaggaaca  120
gcctttaaa  gatctagaa  tactgatga  atggttgaa  tgcgcattt  gcttcagag  180
aagaatgct  gggcagtga  tggaaaagg  ggcaagaat  ttaaggctc  ccgtacaga  240
tacaatgcc  gtgtttcag  cccagacag  agtggcccc  agcgcatac  gagtatcag  300
gctgatatt  agacgattg  agaaattct  aagaaaatc  tccctactt  ggaagaggg  360
ctgcagttg  catcaccca  tgcaaccag  cagctcccg  tcgaatctg  tgctgtgga  420
tgcttaaat  accagcatt  taaagggag  gacttcgac  gcgagctga  actgttgat  480
catcaaagt  tggccggag  aattattgg  gttaaaggt  ctaaaatca  agaacttcg  540
gaaaacact  agacaacaa  caagctttt  caggaatgc  gccctcatt  tactgacag  600
gttgttctt  ttggaggaa  gcccgatag  gttgtagaa  gcatcaaga  catccttga  660
cttatatct  agtctccca  caaaggacg  gcacaacct  atgatccca  cttctatga  720
gaaacctat  attatggtg  ttttacaat  atgtttgat  accgccgag  acgacctgt  780
ggattcccc  tgcggggaa  aggtggttt  gacagaatg  ctcctggtc  gggtgggcg  840
cccatgcct  cttctagaa  agattatga  gatatgagc  ctcgtcgag  accaccacc  900
ccaccacct  gtcgaggtg  acggggtgg  agcagagct  ggaatcttc  tcttcctcc  960
ccaccacca  ccagagggg  agatctcat  gcttacgac  gaagaggac  gcctggaga  1020
cgctatgat  gcatggttg  gttcagtgc  gatgaaact  gggactctg  aattgacac  1080
tggagccca  cagaatggc  aatggctta  gaaccacag  gtggttctg  atatgatta  1140
tcttatgca  ggggccgtg  ctcgtatgg  gatcttggc  gacctatta  cactacaca  1200
gtaactatt  ccaaagatt  ggctggatc  attattggc  aaggtggtc  gcggattaa  1260
caaattcgt  atgagtctg  agcatctat  aaaattgat  aacctttag  aggatctga  1320
gatcggatc  ttaccatta  gggaacaca  gaccagata  agaacgcac  gtatttgct  1380
cagaacagt  tgaagcagt  ttctggaaa  tttttctaa  actagtgaa  aactgaagg  1440
gtcctgcat  ttttttttt  tatctgctt  tgtttaaaa  gccaacatt  ctctgcttc  1500
taggtgttc  gcatttgag  tgtagtgaa  tctttgctg  tcaccagat  taatgtttt  1560
gttccttac  aacagggtt  gggggaggg  atgcaaaaa  actaacatt  aaattttga  1620
acagcagca  agtgagtga  ttttatttt  tgttcattg  tggtggttt  aaaaattcc  1680
cccgtgtaa  tattgtgaa  accttgctt  gtggtcact  taacattgg  gggtgggac  1740
gggaggaaa  taatagtcc  catgtccct  gcatttgtt  agagcagtg  gcagaatgt  1800
atgctcttt  gtaagaaac  ttttatgat  tttaaaata  atttagtga  tctattttt  1860
gtggtcttt  ttttttttt  taaagacaa  ttcaaatgg  ggttgaatt  tccagccca  1920
ccctaaact  aacactaag  ttgattttc  gcagctcct  tgttggata  aagtgcacc  1980
cttggatat  gacaaacac  ttggcaaat  tcagtttgg  tgatttctt  atggttgga  2040
agacttggc  tgataaatt  ccatcacat  ttcatgctt  taataagct  gggattttg  2100
ttgtttttg  aaatgtttg  cactacttt  caacagttt  ctgttagtc  tggggaact  2160
cggtgggga  caatactac  agagtaagc  tctgagtat  tgccagaag  ctggtgggc  2220
atgagcttt  ttaaccaga  taacacttg  ttatggaag  ggctgatgc  gaataaatc  2280
tggttattt  tgttagata  tttctcacc  atagactta  gctgtcaac  gctagcgtc  2340
tgttagttg  actttgtaa  aatatatat  tacttgttt  tccattgta  gcacaatga  2400
agaaaaaag  tgtaccatt  ctctgttgt  tgttgaatt  tgtaggaaa  gtttgtgaa  2460
gattcaaaa  aaatggaaa  gttcctgtg  atgttttgt  tagtaactt  gcatctgta  2520
tgatagttc  aaatccaca  ctaaataaa  cttcatgat  tta  2563



<210> 1830
<211> 463
<212> PRT
<213> Rattus norvegicus
<308> Q07244
<400> 1830

Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn 
  1               5                  10                  15
Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala 
             20                  25                  30
Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu 
         35                  40                  45
Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn 
     50                  55                  60
Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp 
 65                  70                  75                  80
Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr 
                 85                  90                  95
Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu 
             100                105                110
Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp 
         115                120                125
Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp 
     130                135                140
Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile 
 145                150                155                160
Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr 
                 165                170                175
Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val 
             180                185                190
Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile 
         195                200                205
Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro 
     210                215                220
Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr 
 225                230                235                240
Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg 
                 245                250                255
Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro 
             260                265                270
Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly 
         275                280                285
Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala 
     290                295                300
Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu 
 305                310                315                320
Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met 
                 325                330                335
Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp 
             340                345                350
Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly 
         355                360                365
Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly 
     370                375                380
Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly 
 385                390                395                400
Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu 
                 405                410                415
Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp 
             420                425                430
Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln 
         435                440                445
Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ser Gly Lys Phe Phe 
     450                455                460



<210> 1832
<211> 1465
<212> PRT
<213> Homo sapiens
<308> P54296
<400> 1832

Met Ser Leu Val Thr Val Pro Phe Tyr Gln Lys Arg His Arg His Phe 
  1               5                  10                  15
Asp Gln Ser Tyr Arg Asn Ile Gln Thr Arg Tyr Leu Leu Asp Glu Tyr 
             20                  25                  30
Ala Ser Lys Lys Arg Ala Ser Thr Gln Ala Ser Ser Gln Lys Ser Leu 
         35                  40                  45
Ser Gln Arg Ser Ser Ser Gln Arg Ala Ser Ser Gln Thr Ser Leu Gly 
     50                  55                  60
Gly Thr Ile Cys Arg Val Cys Ala Lys Arg Val Ser Thr Gln Glu Asp 
 65                  70                  75                  80
Glu Glu Gln Glu Asn Arg Ser Arg Tyr Gln Ser Leu Val Ala Ala Tyr 
                 85                  90                  95
Gly Glu Ala Lys Arg His Gly Phe Leu Ser Glu Leu Ala His Leu Glu 
             100                105                110
Glu Asp Val His Leu Ala Arg Ser Gln Ala Arg Asp Lys Leu Asp Lys 
         115                120                125
Tyr Ala Ile Gln Gln Met Met Glu Asp Lys Leu Ala Trp Glu Arg His 
     130                135                140
Thr Phe Glu Glu Arg Ile Ser Arg Ala Pro Glu Ile Leu Val Arg Leu 
 145                150                155                160
Arg Ser His Thr Val Trp Glu Arg Met Ser Val Lys Leu Cys Phe Thr 
                 165                170                175
Val Gln Gly Phe Pro Thr Pro Val Val Gln Trp Tyr Lys Asp Gly Ser 
             180                185                190
Leu Ile Cys Gln Ala Ala Glu Pro Gly Lys Tyr Arg Ile Glu Ser Asn 
         195                200                205
Tyr Gly Val His Thr Leu Glu Ile Asn Arg Ala Asp Phe Asp Asp Thr 
     210                215                220
Ala Thr Tyr Ser Ala Val Ala Thr Asn Ala His Gly Gln Val Ser Thr 
 225                230                235                240
Asn Ala Ala Val Val Val Arg Arg Phe Arg Gly Asp Glu Glu Pro Phe 
                 245                250                255
Arg Ser Val Gly Leu Pro Ile Gly Leu Pro Leu Ser Ser Met Ile Pro 
             260                265                270
Tyr Thr His Phe Asp Val Gln Phe Leu Glu Lys Phe Gly Val Thr Phe 
         275                280                285
Arg Arg Glu Gly Glu Thr Val Thr Leu Lys Cys Thr Met Leu Val Thr 
     290                295                300
Pro Asp Leu Lys Arg Val Gln Pro Arg Ala Glu Trp Tyr Arg Asp Asp 
 305                310                315                320
Leu Leu Leu Lys Glu Ser Lys Trp Thr Lys Met Phe Phe Gly Glu Gly 
                 325                330                335
Gln Ala Ser Leu Ser Phe Ser His Leu His Lys Asp Asp Glu Gly Leu 
             340                345                350
Tyr Thr Leu Arg Ile Val Ser Arg Gly Gly Val Thr Asp His Ser Ala 
         355                360                365
Phe Leu Phe Val Arg Asp Ala Asp Pro Leu Val Thr Gly Ala Pro Gly 
     370                375                380
Ala Pro Met Asp Leu Gln Cys His Asp Ala Asn Arg Asp Tyr Val Ile 
 385                390                395                400
Val Thr Trp Lys Pro Pro Asn Thr Thr Thr Glu Ser Pro Val Met Gly 
                 405                410                415
Tyr Phe Val Asp Arg Cys Glu Val Gly Thr Asn Asn Trp Val Gln Cys 
             420                425                430
Asn Asp Ala Pro Val Lys Ile Cys Lys Tyr Pro Val Thr Gly Leu Phe 
         435                440                445
Glu Gly Arg Ser Tyr Ile Phe Arg Val Arg Ala Val Asn Ser Ala Gly 
     450                455                460
Ile Ser Arg Pro Ser Arg Val Ser Asp Ala Val Ala Ala Leu Asp Pro 
 465                470                475                480
Leu Asp Leu Arg Arg Leu Gln Ala Val His Leu Glu Gly Glu Lys Glu 
                 485                490                495
Ile Ala Ile Tyr Gln Asp Asp Leu Glu Gly Asp Ala Gln Val Pro Gly 
             500                505                510
Pro Pro Thr Gly Val His Ala Ser Glu Ile Ser Arg Asn Tyr Val Val 
         515                520                525
Leu Ser Trp Glu Pro Pro Thr Pro Arg Gly Lys Asp Pro Leu Met Tyr 
     530                535                540
Phe Ile Glu Lys Ser Val Val Gly Ser Gly Thr Trp Gln Arg Val Asn 
 545                550                555                560
Ala Gln Thr Ala Val Arg Ser Pro Arg Tyr Ala Val Phe Asp Leu Met 
                 565                570                575
Glu Gly Lys Ser Tyr Val Phe Arg Val Leu Ser Ala Asn Arg His Gly 
             580                585                590
Leu Ser Glu Pro Ser Glu Ile Thr Ser Pro Ile Gln Ala Gln Asp Val 
         595                600                605
Thr Val Val Pro Ser Ala Pro Gly Arg Val Leu Ala Ser Arg Asn Thr 
     610                615                620
Lys Thr Ser Val Val Val Gln Trp Asp Arg Pro Lys His Glu Glu Asp 
 625                630                635                640
Leu Leu Gly Tyr Tyr Val Asp Cys Cys Val Ala Gly Thr Asn Leu Trp 
                 645                650                655
Glu Pro Cys Asn His Lys Pro Ile Gly Tyr Asn Arg Phe Val Val His 
             660                665                670
Gly Leu Thr Thr Gly Glu Gln Tyr Ile Phe Arg Val Lys Ala Val Asn 
         675                680                685
Ala Val Gly Met Ser Glu Asn Ser Gln Glu Ser Asp Val Ile Lys Val 
     690                695                700
Gln Ala Ala Leu Thr Val Pro Ser His Pro Tyr Gly Ile Thr Leu Leu 
 705                710                715                720
Asn Cys Asp Gly His Ser Met Thr Leu Gly Trp Lys Val Pro Lys Phe 
                 725                730                735
Ser Gly Gly Ser Pro Ile Leu Gly Tyr Tyr Leu Asp Lys Arg Glu Val 
             740                745                750
His His Lys Asn Trp His Glu Val Asn Ser Ser Pro Ser Lys Pro Thr 
         755                760                765
Ile Leu Thr Val Asp Gly Leu Thr Glu Gly Ser Leu Tyr Glu Phe Lys 
     770                775                780
Ile Ala Ala Val Asn Leu Ala Gly Ile Gly Glu Pro Ser Asp Pro Ser 
 785                790                795                800
Glu His Phe Lys Cys Glu Ala Trp Thr Met Pro Glu Pro Gly Pro Ala 
                 805                810                815
Tyr Asp Leu Thr Phe Cys Glu Val Arg Asp Thr Ser Leu Val Met Leu 
             820                825                830
Trp Lys Ala Pro Val Tyr Ser Gly Ser Ser Pro Val Ser Gly Tyr Phe 
         835                840                845
Val Asp Phe Arg Glu Glu Asp Ala Gly Glu Trp Ile Thr Val Asp Gln 
     850                855                860
Thr Thr Thr Ala Ser Arg Tyr Leu Lys Val Ser Asp Leu Gln Gln Gly 
 865                870                875                880
Lys Thr Tyr Val Phe Arg Val Arg Ala Val Asn Ala Asn Gly Val Gly 
                 885                890                895
Lys Pro Ser Asp Thr Ser Glu Pro Val Leu Val Glu Ala Arg Pro Gly 
             900                905                910
Thr Lys Glu Ile Ser Ala Gly Val Asp Glu Gln Gly Asn Ile Tyr Leu 
         915                920                925
Gly Phe Asp Cys Gln Glu Met Thr Asp Ala Ser Gln Phe Thr Trp Cys 
     930                935                940
Lys Ser Tyr Glu Glu Ile Ser Asp Asp Glu Arg Phe Lys Ile Glu Thr 
 945                950                955                960
Val Gly Asp His Ser Lys Leu Tyr Leu Lys Asn Pro Asp Lys Glu Asp 
                 965                970                975
Leu Gly Thr Tyr Ser Val Ser Val Ser Asp Thr Asp Gly Val Ser Ser 
             980                985                990
Ser Phe Val Leu Asp Pro Glu Glu Leu Glu Arg Leu Met Ala Leu Ser 
         995                1000                1005
Asn Glu Ile Lys Asn Pro Thr Ile Pro Leu Lys Ser Glu Leu Ala Tyr 
     1010                1015                1020
Glu Ile Phe Asp Lys Gly Arg Val Arg Phe Trp Leu Gln Ala Glu His 
 1025                1030                1035                1040
Leu Ser Pro Asp Ala Ser Tyr Arg Phe Ile Ile Asn Asp Arg Glu Val 
                 1045                1050                1055
Ser Asp Ser Glu Ile His Arg Ile Lys Cys Asp Lys Ala Thr Gly Ile 
             1060                1065                1070
Ile Glu Met Val Met Asp Arg Phe Ser Ile Glu Asn Glu Gly Thr Tyr 
         1075                1080                1085
Thr Val Gln Ile His Asp Gly Lys Ala Lys Ser Gln Ser Ser Leu Val 
     1090                1095                1100
Leu Ile Gly Asp Ala Phe Lys Thr Val Leu Glu Glu Ala Glu Phe Gln 
 1105                1110                1115                1120
Arg Lys Glu Phe Leu Arg Lys Gln Gly Pro His Phe Ala Glu Tyr Leu 
                 1125                1130                1135
His Trp Asp Val Thr Glu Glu Cys Glu Val Arg Leu Val Cys Lys Val 
             1140                1145                1150
Ala Asn Thr Lys Lys Glu Thr Val Phe Lys Trp Leu Lys Asp Asp Ala 
         1155                1160                1165
Leu Tyr Glu Thr Glu Thr Leu Pro Asn Leu Glu Arg Gly Ile Cys Glu 
     1170                1175                1180
Leu Leu Ile Pro Lys Leu Ser Lys Lys Asp His Gly Glu Tyr Lys Ala 
 1185                1190                1195                1200
Thr Leu Lys Asp Asp Arg Gly Gln Asp Val Ser Ile Leu Glu Ile Ala 
                 1205                1210                1215
Gly Lys Val Tyr Asp Asp Met Ile Leu Ala Met Ser Arg Val Cys Gly 
             1220                1225                1230
Lys Ser Ala Ser Pro Leu Lys Val Leu Cys Thr Pro Glu Gly Ile Arg 
         1235                1240                1245
Leu Gln Cys Phe Met Lys Tyr Phe Thr Asp Glu Met Lys Val Asn Trp 
     1250                1255                1260
Cys His Lys Asp Ala Lys Ile Ser Ser Ser Glu His Met Arg Ile Gly 
 1265                1270                1275                1280
Gly Ser Glu Glu Met Ala Trp Leu Gln Ile Cys Glu Pro Thr Glu Lys 
                 1285                1290                1295
Asp Lys Gly Lys Tyr Thr Phe Glu Ile Phe Asp Gly Lys Asp Asn His 
             1300                1305                1310
Gln Arg Ser Leu Asp Leu Ser Gly Gln Ala Phe Asp Glu Ala Phe Ala 
         1315                1320                1325
Glu Phe Gln Gln Phe Lys Ala Ala Ala Phe Ala Glu Lys Asn Arg Gly 
     1330                1335                1340
Arg Leu Ile Gly Gly Leu Pro Asp Val Val Thr Ile Met Glu Gly Lys 
 1345                1350                1355                1360
Thr Leu Asn Leu Thr Cys Thr Val Phe Gly Asn Pro Asp Pro Glu Val 
                 1365                1370                1375
Ile Trp Phe Lys Asn Asp Gln Asp Ile Gln Leu Ser Glu His Phe Ser 
             1380                1385                1390
Val Lys Val Glu Gln Ala Lys Tyr Val Ser Met Thr Ile Lys Gly Val 
         1395                1400                1405
Thr Ser Glu Asp Ser Gly Lys Tyr Ser Ile Asn Ile Lys Asn Lys Tyr 
     1410                1415                1420
Gly Gly Glu Lys Ile Asp Val Thr Val Ser Val Tyr Lys His Gly Glu 
 1425                1430                1435                1440
Lys Ile Pro Asp Met Ala Pro Pro Gln Gln Ala Lys Pro Lys Leu Ile 
                 1445                1450                1455
Pro Ala Ser Ala Ser Ala Ala Gly Gln 
             1460                1465



<210> 1833
<211> 2166
<212> DNA
<213> Rattus norvegicus
<308> D17809
<400> 1833

tggatcaca  tctccatcg  ctgactcag  atgcggctg  accgccggg  cctctatgc  60
ctagttctg  tgcttgcct  cgcctcgct  ggtctcctg  acgccagca  ccgagacgc  120
ccaggtctc  cgaaccctc  ggcattgtg  tcaccccca  aaggtcccc  gaggctcga  180
ctgctagac  ttgccactg  gcctcgcta  gcacacatc  cagtcagga  caaggagca  240
gtggtgggg  tgctggctc  gaacaattg  agttgtgag  ccagcggag  acgctttgc  300
ttgccgttc  tgaggcagg  ccgggcgat  gacttcact  aagcctttg  cgccgagga  360
ctgagggct  tttctatct  cagagagca  gaataccag  ccttccttg  aaggagccg  420
tccctggct  accagctgc  gatagcccc  gccaactcc  ccttacagt  tcccctgca  480
ggtgtggag  ttcagcccc  caggagcat  ctggtgcca  ggctaagtc  gcaggaagc  540
tctgttcag  aaatatatc  ggtgaacct  attgcttcc  ttggcacct  ggatgtggc  600
ggggaagta  caggggtga  tctcactgg  gaggggcag  cggacctca  ccttgccag  660
ccaattctg  ataaactca  ccgacagct  caactggtg  cttacagca  ccggagcta  720
caagccaac  cagcagaca  agtccggtt  tccaccaag  gacatgaag  ggccttcac  780
atcctcata  gacatcctc  caacccccg  ctgtaccca  catcatccc  accccaagg  840
gcccagtac  acatcagtg  tctggttac  gttgccacc  agacctttc  tcgttatga  900
cggctacgg  cactcattg  cagcatcag  cgcttttac  ctacggtca  catagtaat  960
gctgacgac  gcgacaaac  ggagcgaat  agcgacccc  atgtggagc  ctatttcat  1020
cccttcggc  agggttggt  tgcaggtcg  aacctggcg  tgtcccaag  aaccaccaa  1080
tacgtgctg  gggtggacg  cgactttgt  ttcacggcg  gcacgcggc  ggagaagct  1140
gtggatgtc  tggagagga  gcccctgga  ttggttggg  gcgcggtgc  ggagatctc  1200
ggctacgct  ccacctacc  acagctgct  agtgtggag  cgggcgccc  aggctttgg  1260
aactgcctc  ggcaaaagc  gggcttcca  cacgagctc  ctggctttc  aaactgcgt  1320
gtcaccgac  gcgtagtca  cttcttcct  gcgcgcaca  ataaagtgc  ccaggtggg  1380
tttgaccca  gcctcaacc  ggtggctca  ctggaattc  tcctggatg  tcttggttc  1440
cttcgagtt  gctcctgct  tgatgttgt  gtggatcat  cgtcaaagg  gaagctgcc  1500
tggacatca  aggatccag  ggctgaact  tatgcccgt  accgttacc  gggatcact  1560
gaccaaagt  aggtggcca  acatcgact  ctcttcttc  aacaccggc  acagtgcat  1620
accgccgag  aacgtctga  ttgggcctt  acactgtca  gctgggcct  cctcctccc  1680
gccaggaat  tccagcaac  acccccccc  aatccctga  caccccact  atgaacacc  1740
tggcttccc  accctctcc  ccaatctga  tcctaacag  ggcttgtcc  ggtgacacc  1800
ttcctttct  tgagtgacc  gaggccaga  ggagccata  cctccccca  agccagtgc  1860
aagtcctcc  caaccccac  cctatgggg  aggaaatgg  gaggttcac  ttccaagtg  1920
caaagagcc  agacggact  taagaccct  aagtggaaa  actctcacc  cctgaggtg  1980
gcagggaaa  tcccaattt  caaccccag  gacatgcac  ccaccccag  tctggatcc  2040
gcaccatgt  tcccggctc  aacataccc  tacagaaag  actgtgact  tagttctgt  2100
gggctggtg  acacacggt  gaagccaaa  aaaaaaaaa  aaaaaaaaa  ggggggggg  2160
ggatcc  2166



<210> 1834
<211> 533
<212> PRT
<213> Rattus norvegicus
<308> Q10468
<400> 1834

Met Arg Leu Asp Arg Arg Ala Leu Tyr Ala Leu Val Leu Leu Leu Ala 
  1               5                  10                  15
Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
             20                  25                  30
Leu Pro Asn Pro Leu Ala Leu Trp Ser Pro Pro Gln Gly Pro Pro Arg 
         35                  40                  45
Leu Asp Leu Leu Asp Leu Ala Thr Glu Pro Arg Tyr Ala His Ile Pro 
     50                  55                  60
Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Gln Asn Asn Cys 
 65                  70                  75                  80
Ser Cys Glu Ser Ser Gly Gly Arg Phe Ala Leu Pro Phe Leu Arg Gln 
                 85                  90                  95
Val Arg Ala Ile Asp Phe Thr Lys Ala Phe Asp Ala Glu Glu Leu Arg 
             100                105                110
Ala Val Ser Ile Ser Arg Glu Gln Glu Tyr Gln Ala Phe Leu Ala Arg 
         115                120                125
Ser Arg Ser Leu Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro 
     130                135                140
Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile 
 145                150                155                160
Leu Val Pro Gly Leu Ser Leu Gln Glu Ala Ser Val Gln Glu Ile Tyr 
                 165                170                175
Gln Val Asn Leu Ile Ala Ser Leu Gly Thr Trp Asp Val Ala Gly Glu 
             180                185                190
Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ser Asp Leu Thr Leu 
         195                200                205
Ala Ser Pro Ile Leu Asp Lys Leu Asn Arg Gln Leu Gln Leu Val Thr 
     210                215                220
Tyr Ser Ser Arg Ser Tyr Gln Ala Asn Thr Ala Asp Thr Val Arg Phe 
 225                230                235                240
Ser Thr Lys Gly His Glu Val Ala Phe Thr Ile Leu Ile Arg His Pro 
                 245                250                255
Pro Asn Pro Arg Leu Tyr Pro Pro Ser Ser Leu Pro Gln Gly Ala Gln 
             260                265                270
Tyr Asn Ile Ser Ala Leu Val Thr Val Ala Thr Lys Thr Phe Leu Arg 
         275                280                285
Tyr Asp Arg Leu Arg Ala Leu Ile Ala Ser Ile Arg Arg Phe Tyr Pro 
     290                295                300
Thr Val Thr Ile Val Ile Ala Asp Asp Ser Asp Lys Pro Glu Arg Ile 
 305                310                315                320
Ser Asp Pro His Val Glu His Tyr Phe Met Pro Phe Gly Lys Gly Trp 
                 325                330                335
Phe Ala Gly Arg Asn Leu Ala Val Ser Gln Val Thr Thr Lys Tyr Val 
             340                345                350
Leu Trp Val Asp Asp Asp Phe Val Phe Thr Ala Arg Thr Arg Leu Glu 
         355                360                365
Lys Leu Val Asp Val Leu Glu Arg Thr Pro Leu Asp Leu Val Gly Gly 
     370                375                380
Ala Val Arg Glu Ile Ser Gly Tyr Ala Thr Thr Tyr Arg Gln Leu Leu 
 385                390                395                400
Ser Val Glu Pro Gly Ala Pro Gly Phe Gly Asn Cys Leu Arg Gln Lys 
                 405                410                415
Gln Gly Phe His His Glu Leu Ala Gly Phe Pro Asn Cys Val Val Thr 
             420                425                430
Asp Gly Val Val Asn Phe Phe Leu Ala Arg Thr Asp Lys Val Arg Gln 
         435                440                445
Val Gly Phe Asp Pro Arg Leu Asn Arg Val Ala His Leu Glu Phe Phe 
     450                455                460
Leu Asp Gly Leu Gly Ser Leu Arg Val Gly Ser Cys Ser Asp Val Val 
 465                470                475                480
Val Asp His Ala Ser Lys Val Lys Leu Pro Trp Thr Ser Lys Asp Pro 
                 485                490                495
Gly Ala Glu Leu Tyr Ala Arg Tyr Arg Tyr Pro Gly Ser Leu Asp Gln 
             500                505                510
Ser Gln Val Ala Lys His Arg Leu Leu Phe Phe Lys His Arg Leu Gln 
         515                520                525
Cys Met Thr Ala Glu 
     530



<210> 1835
<211> 2512
<212> DNA
<213> Homo sapiens
<308> M83651
<400> 1835

ggcgagagc  cggcacagc  cggaccgaa  ttttgccgc  gccttagag  gttagacag  60
atgtggctg  gccgccggg  cctgtgcgc  ctggtcctt  tgctcgcct  cgcctcgct  120
gggctcctg  acgcgagca  ccgggacgc  cccggcctc  ggctacctc  tgcgccgtg  180
gcgcccccg  aaagccccc  caggcccga  ctgccagat  ttgctcctg  gccccgcta  240
gcacacatc  cggtcagga  caaggagca  gtagtgggg  tgctggctt  gaacaactg  300
agttgtgag  ccagtgggg  gggcctccc  ctccccttc  agaaacaag  ccgagctat  360
gacctcacc  aggcctttg  ccctgcaga  ctgagggct  cctctgcca  aagagagca  420
gagttccag  cctttctgt  gaggagcca  tccccagct  accagctgc  catagcccc  480
gccaactcc  cgctccagt  ccccctaca  ggtgtggaa  ttcagcccc  caggagcat  540
ttggtgcca  ggctgagcc  tcaggcagc  tctggtcag  aggtatacc  ggtgaacct  600
actgcctcc  taggcacct  ggacgtggc  ggggaagtg  ctggagtta  tctcactgg  660
gagggtcag  cagatctca  ccttgtcag  ccagggctg  accaactca  caggcaact  720
caactggtc  cttacagca  ccgaagcta  cagaccaac  cagcagaca  agtccggtt  780
tccaccgag  gacatgagg  tgctttcac  atccgcata  gacacccgc  caaccctcg  840
ctgtaccca  ctgggtctc  accccaggg  gcccagtac  acatcagcg  tctagtcac  900
attgccacc  agaccttcc  ccgttatga  cggctacgg  ctctcatca  cagtatccg  960
cgcttctac  caacggtta  cgtggtcat  gctgacgac  gcgacaagc  agagcgcgt  1020
agtggcccc  acgtggaac  ctatctcat  cccttcggc  agggctggt  cgcaggccg  1080
aacctggcc  tgtctcaag  aaccaccaa  tacgtgctg  gggtggacg  cgacttcgt  1140
ttcacggcg  ggacgcggc  ggagaggct  gtggacgtg  tggagcgga  gccgctgga  1200
ctggtgggg  gcgcggtgc  cgagatctc  ggctttgcc  ccacttatc  gcagctgct  1260
agcgtggag  ccggcgccc  aggcctcgg  aactgcctc  ggcaaaggc  cggcttcca  1320
cacgagctc  tcggcttcc  aggctgcgt  gtcaccgac  gcgtggtta  cttcttcct  1380
gcgcggact  acaaggtgc  cgaggtcgg  ttcgacccc  gcctcagcc  cgtggctca  1440
ctggaattc  tcttggatg  gcttggttc  cttcgggtt  gctcctgct  cgacgtcgt  1500
gtggatcat  catccaaac  gaagctgcc  tggacatca  gggatgccg  agcagagac  1560
tacgcccgg  accgttacc  aggatcact  gacgagagc  agatggcca  acaccggct  1620
ctcttcttc  aacaccggc  gcagtgcat  acctcccag  gatggcccg  tggggattt  1680
tgactgtca  gctgggcct  cctccttgt  cctgccagg  atttccaac  aaccccacc  1740
ccctgtgag  actctactg  ctgtccctg  gcctctagt  cctcactct  ccttttcag  1800
acctgatgc  cagtagggg  tgtcctggt  acacccctc  tttttccag  gcccagagg  1860
ctggtggag  cataacctc  cccacagcc  gtgccaagt  ctccccctg  ccattctca  1920
ggggcagga  atgggggga  cactttcca  gtgccaaag  gcccagagg  actctaaga  1980
cctaaggtg  aaacactgt  ctctcatct  gggaccgag  gggtgggga  gttccccaa  2040
acataatcc  aagactgtg  ccctcatct  catcttcag  tccagtact  tgtgtacct  2100
ctccagccc  acccccaca  agagaactt  tggctctgg  gctggggtg  gggctggtg  2160
ttggtgaaa  ccattctta  ttgtgtctc  gcaatgctg  gggcacaaa  gaaggggca  2220
cagagtccc  gtgcaaaca  ctagactca  ttcatggat  ccaaagctc  cagcttcat  2280
ttattagtt  cgttaggta  gggggttca  gggtcatgg  cctcatcac  cacatgtca  2340
cagggccct  ctgcactcc  catgatgag  tcagaccca  acggtgcaa  tctttgggt  2400
agtgagctc  tggagaaga  aggagacat  tcaggaata  attaggcac  cctcttcct  2460
aatgaaatg  ggcagtcct  tcaggggta  cccacctac  tagggatct  ag  2512



<210> 1836
<211> 533
<212> PRT
<213> Homo sapiens
<308> Q00973
<400> 1836

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
  1               5                  10                  15
Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
             20                  25                  30
Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
         35                  40                  45
Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
     50                  55                  60
Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
 65                  70                  75                  80
Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln 
                 85                  90                  95
Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg 
             100                105                110
Ala Ala Ser Ala Thr Arg Glu Gln Glu Phe Gln Ala Phe Leu Ser Arg 
         115                120                125
Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro 
     130                135                140
Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile 
 145                150                155                160
Leu Val Pro Gly Leu Ser Leu Gln Ala Ala Ser Gly Gln Glu Val Tyr 
                 165                170                175
Gln Val Asn Leu Thr Ala Ser Leu Gly Thr Trp Asp Val Ala Gly Glu 
             180                185                190
Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ala Asp Leu Thr Leu 
         195                200                205
Val Ser Pro Gly Leu Asp Gln Leu Asn Arg Gln Leu Gln Leu Val Thr 
     210                215                220
Tyr Ser Ser Arg Ser Tyr Gln Thr Asn Thr Ala Asp Thr Val Arg Phe 
 225                230                235                240
Ser Thr Glu Gly His Glu Ala Ala Phe Thr Ile Arg Ile Arg His Pro 
                 245                250                255
Pro Asn Pro Arg Leu Tyr Pro Pro Gly Ser Leu Pro Gln Gly Ala Gln 
             260                265                270
Tyr Asn Ile Ser Ala Leu Val Thr Ile Ala Thr Lys Thr Phe Leu Arg 
         275                280                285
Tyr Asp Arg Leu Arg Ala Leu Ile Thr Ser Ile Arg Arg Phe Tyr Pro 
     290                295                300
Thr Val Thr Val Val Ile Ala Asp Asp Ser Asp Lys Pro Glu Arg Val 
 305                310                315                320
Ser Gly Pro Tyr Val Glu His Tyr Leu Met Pro Phe Gly Lys Gly Trp 
                 325                330                335
Phe Ala Gly Arg Asn Leu Ala Val Ser Gln Val Thr Thr Lys Tyr Val 
             340                345                350
Leu Trp Val Asp Asp Asp Phe Val Phe Thr Ala Arg Thr Arg Leu Glu 
         355                360                365
Arg Leu Val Asp Val Leu Glu Arg Thr Pro Leu Asp Leu Val Gly Gly 
     370                375                380
Ala Val Arg Glu Ile Ser Gly Phe Ala Thr Thr Tyr Arg Gln Leu Leu 
 385                390                395                400
Ser Val Glu Pro Gly Ala Pro Gly Leu Gly Asn Cys Leu Arg Gln Arg 
                 405                410                415
Arg Gly Phe His His Glu Leu Val Gly Phe Pro Gly Cys Val Val Thr 
             420                425                430
Asp Gly Val Val Asn Phe Phe Leu Ala Arg Thr Asp Lys Val Arg Glu 
         435                440                445
Val Gly Phe Asp Pro Arg Leu Ser Arg Val Ala His Leu Glu Phe Phe 
     450                455                460
Leu Asp Gly Leu Gly Ser Leu Arg Val Gly Ser Cys Ser Asp Val Val 
 465                470                475                480
Val Asp His Ala Ser Lys Leu Lys Leu Pro Trp Thr Ser Arg Asp Ala 
                 485                490                495
Gly Ala Glu Thr Tyr Ala Arg Tyr Arg Tyr Pro Gly Ser Leu Asp Glu 
             500                505                510
Ser Gln Met Ala Lys His Arg Leu Leu Phe Phe Lys His Arg Leu Gln 
         515                520                525
Cys Met Thr Ser Gln 
     530



<210> 1837
<211> 2680
<212> DNA
<213> Rattus norvegicus
<308> D21132
<400> 1837

gcagctgtg  gggcttccc  gaagatggt  ctgattaag  aattccgtg  agttttgcc  60
tgttctgtt  aagagtatc  ggttggaca  ctttactct  ttgcagaag  gagtaagaa  120
gaaactggt  gtggagaag  aatcgaagt  ttgaagaat  aaccttatg  aaatgatgg  180
gagaaggga  agtacacac  caaaatcta  cacctgaag  gcaaagtcc  tgcgttcgt  240
aggatgatt  ctcccgagg  ctccttggt  ttccatgag  aagcctgga  tgcttaccc  300
tactgcaga  caattgtaa  gaatgagta  atgaaagat  acttcttca  caaaatcga  360
acatggcac  aacctgact  gggaacatt  gaaaatgtt  acggtttag  tccaaacac  420
tggaaaacc  ttgaaattg  ccacataga  attgcagat  gaagtcagg  tgaaccagc  480
gactacaaa  ctgatgagg  ccctgcgtt  ttccagtca  tcaagacca  gagaggccc  540
ctgggacct  actggaaga  ggagctggc  aacacccct  actgtccta  gatgtgtgc  600
tataagctg  tgaccatca  gttcaagtg  tgggggctg  agagcaaag  agagaactt  660
atccagaag  aagaaaaac  gatatttac  aacttacat  gccagctct  ttgttggat  720
gacaagtgg  ttgacctga  aatggaaga  attaggaga  tggaggacg  gactcagaa  780
gaactagaa  caatgcgta  gaagggttc  gtccgaggc  cgtcggctg  tgatgccta  840
atgagcccc  gtaggtcag  gacattatc  aactgtcta  ggagtcaag  ccaagtgag  900
gggaccagt  cggcctgcg  cgactaaag  caccagcgt  tcagtgttg  cggatgttt  960
cagtgtgtg  ctctgacgg  tcgggcaca  ttgtgcaca  tcgagggca  acacacacc  1020
atgcacaca  actcacact  tatgtatgt  tgtagctgt  tgtaaagca  atatggcta  1080
aggcctaga  acacacgag  gtatatata  atgtacatg  gaagatgga  cagtacctt  1140
tctccaaag  actgcacct  tcttcagca  aaatactaa  gaaaatatt  tcaatatat  1200
tacctggaa  agatattaa  acccatcaa  atgatgccc  ggatggaca  acggactgc  1260
atgtggtgc  ctgtggtgc  ggctggcgt  cttcgtgaa  gccaggtgt  gaccagtgt  1320
tacagcctt  ggttaggtt  ctgtttttt  caagtcacc  cacacacac  cacgtttag  1380
ctcaaccca  cagcaacaa  tcctacaga  agatttttt  aaattttta  atactccag  1440
gactctgga  tgtaaactc  ggatgtatt  ataactatt  atttctggg  ggccactat  1500
ttccagcca  atccaacaa  atctgtcaa  taaggagtg  aagctcttt  ttggtttgc  1560
cgagggttg  ggatatcct  ttttttaaa  aattgccac  ttttattgg  tttttgtat  1620
ttgaatttc  agtattttt  tatatcaaa  ctagcaaaa  acggtgatg  cggtttgtg  1680
tttataata  acactgaca  tattcagat  ctggctaag  aaacagggt  atcaggcaa  1740
taacctgag  ggcactgga  gctgtgcag  gccattctg  ggagttttg  ttctgaaat  1800
gcttttctg  aattacggc  tggagactg  atggtctgt  ttgctctca  ttcacaggg  1860
aggagagtg  tcccgcccg  ctgtttcca  ttacagtcc  agctaggag  aaatgctga  1920
gggagcagg  acagcttga  catgacaca  gcctgtccc  gtcctgagg  ccagctaga  1980
ctgggcctt  ccgacagct  tgcttcctc  tcctgtatc  cctcctcct  ccccttcct  2040
ttctgtctc  actttctcc  tttttttta  gagaaagga  cagtagctg  gaaggattt  2100
ctttttttt  cctttccgt  tgatgctat  ctcctctcg  cagtcctgg  accctgacc  2160
gcatcacac  gttgaatcc  tcaggttac  cactgcctt  taacctcca  cctgcagtc  2220
gagcacggt  gtgacaccc  tttgttgac  ggcttgacc  tcatgtccc  tctgccctg  2280
cctgtgtcc  atgggggaa  tggcagaga  tcccactgc  tcacactgc  ctgttagcc  2340
cagcaacaa  ccctgggtt  catgtcctc  aagctctag  taaaggtgg  tattccctg  2400
gcactgctg  aagctggga  ggtcaccac  agaagggtc  ttgccagcc  tgtctcctc  2460
agtgaaacc  gatcacaga  atccatagt  tctctgaga  ctggggcac  caaggaaac  2520
agagcccag  atggattct  gtgttgctc  agcagctgt  gagattgag  gatgtggtg  2580
atgcaaaga  cccagttta  ttggcagtc  cctgtgtaa  tcacagtaa  acaaagtga  2640
atcgaaaca  gaataaatt  gatctcaaa  tgaaaaaaaa  2680



<210> 1838
<211> 270
<212> PRT
<213> Rattus norvegicus
<308> P53812
<400> 1838

Val Leu Ile Lys Glu Phe Arg Val Val Leu Pro Cys Ser Val Gln Glu 
  1               5                  10                  15
Tyr Gln Val Gly Gln Leu Tyr Ser Val Ala Glu Ala Ser Lys Asn Glu 
             20                  25                  30
Thr Gly Gly Gly Glu Gly Ile Glu Val Leu Lys Asn Glu Pro Tyr Glu 
         35                  40                  45
Asn Asp Gly Glu Lys Gly Gln Tyr Thr His Lys Ile Tyr His Leu Lys 
     50                  55                  60
Ser Lys Val Pro Ala Phe Val Arg Met Ile Ala Pro Glu Gly Ser Leu 
 65                  70                  75                  80
Val Phe His Glu Lys Ala Trp Asn Ala Tyr Pro Tyr Cys Arg Thr Ile 
                 85                  90                  95
Val Thr Asn Glu Tyr Met Lys Asp Asp Phe Phe Ile Lys Ile Glu Thr 
             100                105                110
Trp His Lys Pro Asp Leu Gly Thr Leu Glu Asn Val His Gly Leu Asp 
         115                120                125
Pro Asn Thr Trp Lys Thr Val Glu Ile Val His Ile Asp Ile Ala Asp 
     130                135                140
Arg Ser Gln Val Glu Pro Ala Asp Tyr Lys Ala Asp Glu Asp Pro Ala 
 145                150                155                160
Leu Phe Gln Ser Val Lys Thr Lys Arg Gly Pro Leu Gly Pro Asn Trp 
                 165                170                175
Lys Lys Glu Leu Ala Asn Thr Pro Asp Cys Pro Lys Met Cys Ala Tyr 
             180                185                190
Lys Leu Val Thr Ile Lys Phe Lys Trp Trp Gly Leu Gln Ser Lys Val 
         195                200                205
Glu Asn Phe Ile Gln Lys Gln Glu Lys Arg Ile Phe Thr Asn Leu His 
     210                215                220
Arg Gln Leu Phe Cys Trp Ile Asp Lys Trp Ile Asp Leu Thr Met Glu 
 225                230                235                240
Asp Ile Arg Arg Met Glu Asp Glu Thr Gln Lys Glu Leu Glu Thr Met 
                 245                250                255
Arg Lys Lys Gly Ser Val Arg Gly Thr Ser Ala Ala Asp Ala 
             260                265                270



<210> 1839
<211> 2906
<212> DNA
<213> Homo sapiens
<308> NM_012399
<400> 1839

cggtggtat  ggcggcagc  gtgaggggg  tccgggaag  tggtgctga  caaggaatt  60
cgtgtggtt  tgccatgtt  tgttcagga  tatcaggtt  ggcagcttt  ctctgttgc  120
gaagctagt  agaatgaga  tggtggtgg  gaaggaatt  aagtcttaa  gaatgaacc  180
tatgagaag  atggagaaa  gggacagta  acgcacaaa  tttatcacc  aaagagcaa  240
gtgcctgca  tcgtgagga  gattgctcc  gagggctcc  tggtgtttc  tgagaaagc  300
tggaatgcg  acccctact  tagaacaat  gtaacgaat  aatatatga  agatgattt  360
ttcattaaa  tcgaaacat  gcacaaacc  gacttggga  cattagaaa  tgtacatgg  420
ttagatcca  acacatgga  aactgttga  attgtccat  tagatattg  agatagaag  480
caagttgaa  cagcagact  caaagctga  gaagaccca  cattattcc  gtcagtcaa  540
accaagaga  gccctttgg  acccaactg  aagaaggag  tggcaaaca  ccctgactg  600
ccccagatg  gtgcctata  gctggtgac  atcaaattc  agtggtggg  actgcaaag  660
aaagtagaa  acttcattc  aaagcaaga  aaacggata  ttacaaact  ccatcgcca  720
cttttttgt  ggattgaca  gtggatcga  ctcacgatg  aagacatta  gagaatgga  780
gacgagact  agaaagaac  agaaacaat  cgtaagagg  gttccgttc  aggcacgtc  840
gctgctgat  tctagatga  tcccctgta  ggtcagaga  aatgtcaaa  tgtttacgt  900
atcaaggtc  agtgagggg  acaagcgca  ccagtgatg  gtgaagaag  atctgacca  960
tatcttgca  tgttgacgt  tcccagatg  gtgcttgtg  tgatacaca  acatgcaca  1020
gttctcaac  acgtgtgta  atatgtatg  gtgcatatg  ctgtagctg  atataaagc  1080
catgtagag  tacagatcc  gatacacac  cttgtgtat  tatgtacat  cagacatac  1140
gaagggatt  gtacaattt  tccaaagta  tgtacctat  ttcagcaag  atgcaaaag  1200
aaatatttt  aatatatat  cctggaaca  attttaata  ttatcagag  aataccatt  1260
atggacaaa  tgactgcaa  gtaatacta  ctggtatgt  tcataaatg  caagctgtg  1320
accaacata  atagccttt  attattttt  tcttctttt  agtcagtct  ttataaatt  1380
ttttttagt  ccataagca  tagactccc  cagaaaatt  cttcaaaat  ttttggtgt  1440
ccaatgaat  tgggatgta  actctgaat  tatttataa  tatttattt  tggatggtc  1500
ttatcttgt  gccaaattt  acaatataa  gtaaggagc  aagttacag  ccagttttt  1560
cttgtttgc  ctgagggaa  aatcctttt  aaaaaaatt  ctggttttt  ttggatttt  1620
gtattttaa  tttcaaata  ttttctaca  caaacctag  aaaaatgga  atgacggtt  1680
ctgatttat  ataaatact  gacagtttt  aggctcctg  tagacaaac  cattgatga  1740
gaaattagt  ttaatagga  tgtaggctg  gtagaaaag  tggaaatat  gcacttcat  1800
gagtcttgt  ttgaagatg  cagttttct  taactacag  ttggaaact  tgcaaatgg  1860
ctagattcc  cagagctca  atgatagga  atagttagt  atgacattt  gctcttctt  1920
tgggaacac  cacttcaag  aggagatag  gactttgag  taggaacag  ttaagatgc  1980
gtgtgagtc  ggcctgcgt  cggtgagga  gccccgcca  gagactggt  gacatctga  2040
tgtgggatg  gctctcaag  aggacgtca  caggacaga  tctgaatag  catcatgag  2100
gtgctggtc  gaaacggct  ccacttttt  taatttaat  ttatttttt  tttaaagga  2160
ggaacaata  ctaggtaag  tttttatca  ctttctctg  ctgaatcca  tttttcctc  2220
gtcagtcct  gaagcttga  tagaattat  ttgttgaag  cttcaggtc  caaactgtc  2280
tttgtaacc  cctgtccct  ctaaaacac  ccaacccct  cagtcaaat  acattagta  2340
tctgatttg  tgacagtcc  gccctgcct  ctcctcgtt  tcccacatg  cctgcatcc  2400
tcccccact  gagtgattt  agtgaatca  acaaggaag  atgtgtagg  tcactactg  2460
attgcaata  cctgttatc  tcagcaaca  aacccacat  tcatacatc  tttgtgtac  2520
caggataaa  actgatgtt  actctctgg  cactgttgt  agataggtt  tgtcagagc  2580
taatcattg  ctgcaaagt  tttggtgcg  ggaagatta  tgctaattt  gtgaaataa  2640
gagtctagc  ctctccttt  aatgaactt  actctcgct  gcatctgta  tatcattgg  2700
agcttaggc  cacatggaa  tgagagccc  gcgcatgga  tttaatgtt  ttctaacaa  2760
tgtggagat  tgagggaat  tgtggtgaa  gtaaaatac  tagtttact  gccagtctc  2820
tgtgtaaat  acagtaaaa  aaagtaaat  aaatttaaa  aaaaaataa  tttgatcac  2880
aaatgaaaa  aaaaaaaaa  aaaaaa  2906



<210> 1840
<211> 270
<212> PRT
<213> Homo sapiens
<308> P48739
<400> 1840

Val Leu Ile Lys Glu Phe Arg Val Val Leu Pro Cys Ser Val Gln Glu 
  1               5                  10                  15
Tyr Gln Val Gly Gln Leu Tyr Ser Val Ala Glu Ala Ser Lys Asn Glu 
             20                  25                  30
Thr Gly Gly Gly Glu Gly Ile Glu Val Leu Lys Asn Glu Pro Tyr Glu 
         35                  40                  45
Lys Asp Gly Glu Lys Gly Gln Tyr Thr His Lys Ile Tyr His Leu Lys 
     50                  55                  60
Ser Lys Val Pro Ala Phe Val Arg Met Ile Ala Pro Glu Gly Ser Leu 
 65                  70                  75                  80
Val Phe His Glu Lys Ala Trp Asn Ala Tyr Pro Tyr Cys Arg Thr Ile 
                 85                  90                  95
Val Thr Asn Glu Tyr Met Lys Asp Asp Phe Phe Ile Lys Ile Glu Thr 
             100                105                110
Trp His Lys Pro Asp Leu Gly Thr Leu Glu Asn Val His Gly Leu Asp 
         115                120                125
Pro Asn Thr Trp Lys Thr Val Glu Ile Val His Ile Asp Ile Ala Asp 
     130                135                140
Arg Ser Gln Val Glu Pro Ala Asp Tyr Lys Ala Asp Glu Asp Pro Ala 
 145                150                155                160
Leu Phe Gln Ser Val Lys Thr Lys Arg Gly Pro Leu Gly Pro Asn Trp 
                 165                170                175
Lys Lys Glu Leu Ala Asn Ser Pro Asp Cys Pro Gln Met Cys Ala Tyr 
             180                185                190
Lys Leu Val Thr Ile Lys Phe Lys Trp Trp Gly Leu Gln Ser Lys Val 
         195                200                205
Glu Asn Phe Ile Gln Lys Gln Glu Lys Arg Ile Phe Thr Asn Phe His 
     210                215                220
Arg Gln Leu Phe Cys Trp Ile Asp Lys Trp Ile Asp Leu Thr Met Glu 
 225                230                235                240
Asp Ile Arg Arg Met Glu Asp Glu Thr Gln Lys Glu Leu Glu Thr Met 
                 245                250                255
Arg Lys Arg Gly Ser Val Arg Gly Thr Ser Ala Ala Asp Val 
             260                265                270



<210> 1841
<211> 617
<212> DNA
<213> Rattus norvegicus
<308> D21869
<400> 1841

gaagccaaa  ccctgggga  cggcaaggc  atcgccgtg  tgacctctg  tggagatgc  60
caaggtatg  atgctgcgg  cagggctgt  gtacgagtt  gcatcttca  gggcgcccg  120
gtcttcttt  tccatgagg  ttaccaagg  ctggtggat  gtggagagc  catcaggga  180
gccacctgg  agagcgtgt  catgatgct  cagctggga  gcacggtga  tggaagtgc  240
cgatgcaag  acttccggg  gcgagaagg  cgactccga  ctgcccaca  cctggtgaa  300
cgggggatc  ccaatctgt  tgtcatcgg  ggcgatggc  gcctcactg  ggctgacac  360
tttcgttca  agtggagtg  cttattgaa  gacctccag  aagatggga  gatcacagc  420
gaggaggct  caaagtcca  ctacctgaa  atcgtgggc  tggttggct  aatcgacaa  480
gacttctgt  gcactgata  gaccattgg  actgacttt  ccctgcacc  cattgtaga  540
atcgtggac  ccatcacca  caccgctca  agccaccag  ggacatttg  gttagaagt  600
atgggccgc  actgtgg  617



<210> 1842
<211> 780
<212> PRT
<213> Rattus norvegicus
<308> NP_113903
<400> 1842

Met Thr His Glu Glu His His Glu Ala Lys Thr Leu Gly Ile Gly Lys 
  1               5                  10                  15
Ala Ile Ala Val Leu Thr Ser Gly Gly Asp Ala Gln Gly Met Asn Ala 
             20                  25                  30
Thr Val Arg Ala Val Val Arg Val Gly Ile Phe Thr Gly Leu Arg Val 
         35                  40                  45
Phe Phe Val His Glu Gly Tyr Gln Gly Leu Val Asp Gly Gly Glu His 
     50                  55                  60
Ile Arg Glu Ala Thr Trp Glu Ser Val Ser Met Met Leu Gln Leu Gly 
 65                  70                  75                  80
Gly Thr Val Ile Gly Ser Ala Arg Cys Lys Asp Phe Arg Glu Arg Glu 
                 85                  90                  95
Gly Arg Leu Arg Ala Ala His Asn Leu Val Lys Arg Gly Ile Thr Asn 
             100                105                110
Leu Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala Asp Thr Phe 
         115                120                125
Arg Ser Glu Trp Ser Asp Leu Leu Asn Asp Leu Gln Lys Asp Gly Lys 
     130                135                140
Ile Thr Ala Glu Glu Arg Thr Lys Ser Ser Tyr Leu Asn Ile Val Phe 
 145                150                155                160
Leu Val Gly Ser Ile Asp Asn Asp Phe Cys Gly Thr Asp Met Thr Ile 
                 165                170                175
Gly Thr Asp Ser Ala Leu His Arg Ile Val Glu Ile Val Asp Ala Ile 
             180                185                190
Thr Thr Thr Ala Gln Ser His Gln Arg Thr Phe Val Leu Glu Val Met 
         195                200                205
Gly Arg His Cys Gly Tyr Leu Ala Leu Val Thr Ser Leu Ser Cys Gly 
     210                215                220
Ala Asp Trp Val Phe Ile Pro Glu Cys Pro Pro Asp Asp Asp Trp Glu 
 225                230                235                240
Glu His Leu Cys Arg Arg Leu Ser Glu Thr Arg Thr Arg Gly Ser Arg 
                 245                250                255
Leu Asn Ile Ile Ile Val Ala Glu Gly Ala Ile Asp Lys Asn Gly Lys 
             260                265                270
Pro Ile Thr Ser Glu Asp Ile Lys Asn Leu Val Val Lys Arg Leu Gly 
         275                280                285
Tyr Asp Thr Arg Val Thr Val Leu Gly His Val Gln Arg Gly Gly Thr 
     290                295                300
Pro Ser Ala Phe Asp Arg Ile Leu Gly Ser Arg Met Gly Val Glu Ala 
 305                310                315                320
Val Met Ala Leu Leu Glu Gly Thr Pro Asp Thr Pro Ala Cys Val Val 
                 325                330                335
Ser Leu Ser Gly Asn Thr Ala Val Arg Leu Pro Leu Met Glu Cys Val 
             340                345                350
Gln Val Thr Lys Asp Val Thr Lys Ala Met Asp Glu Lys Arg Phe Asp 
         355                360                365
Glu Ala Ile Lys Leu Arg Gly Arg Ser Phe Met Asn Asn Trp Glu Val 
     370                375                380
Tyr Lys Leu Leu Ala His Val Arg Pro Pro Val Ser Lys Gly Gly Leu 
 385                390                395                400
His Thr Val Ala Val Met Asn Val Gly Ala Pro Ala Ala Gly Met Asn 
                 405                410                415
Ala Ala Val Arg Ser Thr Val Arg Ile Gly Leu Ile Gln Gly Asn Arg 
             420                425                430
Val Leu Val Val His Asp Gly Phe Glu Gly Leu Ala Lys Gly Gln Ile 
         435                440                445
Glu Glu Ala Gly Trp Ser Tyr Val Gly Gly Trp Thr Gly Gln Gly Gly 
     450                455                460
Ser Lys Leu Gly Thr Lys Arg Thr Leu Pro Lys Lys Asn Leu Glu Gln 
 465                470                475                480
Ile Ser Ala Asn Ile Thr Lys Tyr Asn Ile Gln Gly Leu Val Ile Ile 
                 485                490                495
Gly Gly Phe Glu Ala Tyr Thr Gly Gly Leu Glu Leu Met Glu Gly Arg 
             500                505                510
Lys Gln Phe Asp Glu Leu Cys Ile Pro Phe Val Val Ile Pro Ala Thr 
         515                520                525
Val Ser Asn Asn Val Pro Gly Ser Asp Phe Ser Ile Gly Ala Asp Thr 
     530                535                540
Ala Leu Asn Thr Ile Cys Thr Thr Cys Asp Arg Ile Lys Gln Ser Ala 
 545                550                555                560
Ala Gly Thr Lys Arg Arg Val Phe Ile Ile Glu Thr Met Gly Gly Tyr 
                 565                570                575
Cys Gly Tyr Leu Ala Thr Met Ala Gly Leu Ala Ala Gly Ala Asp Ala 
             580                585                590
Ala Tyr Ile Phe Glu Glu Pro Phe Thr Ile Arg Asp Leu Gln Val Asn 
         595                600                605
Val Glu His Leu Val Gln Lys Met Lys Thr Thr Val Lys Arg Gly Leu 
     610                615                620
Val Leu Arg Asn Glu Lys Cys Asn Glu Asn Tyr Thr Thr Asp Phe Ile 
 625                630                635                640
Phe Asn Leu Tyr Ser Glu Glu Gly Lys Gly Ile Phe Asp Ser Arg Lys 
                 645                650                655
Asn Val Leu Gly His Met Gln Gln Gly Gly Asn Pro Thr Pro Phe Asp 
             660                665                670
Arg Asn Phe Ala Thr Lys Met Gly Ala Lys Ala Thr Asn Trp Met Ser 
         675                680                685
Gly Lys Ile Lys Glu Ser Tyr Arg Asn Gly Arg Ile Phe Ala Asn Thr 
     690                695                700
Pro Asp Ser Gly Cys Val Leu Gly Met Arg Lys Arg Ala Leu Val Phe 
 705                710                715                720
Gln Pro Val Thr Glu Leu Lys Asp Gln Thr Asp Phe Glu His Arg Ile 
                 725                730                735
Pro Lys Glu Gln Trp Trp Leu Lys Leu Arg Pro Ile Leu Lys Ile Leu 
             740                745                750
Ala Lys Tyr Glu Ile Asp Leu Asp Thr Ser Asp His Ala His Leu Glu 
         755                760                765
His Ile Ser Arg Lys Arg Ser Gly Glu Ala Ala Val 
     770                775                780



<210> 1843
<211> 2670
<212> DNA
<213> Homo sapiens
<308> BC007798
<400> 1843

ggcacgagg  catgaagag  accatgcag  caaaaccct  gggattggc  aagccattg  60
tgtcttaac  tctggtgga  atgcccaag  tatgaatgc  gctgtcagg  ctgtggttc  120
agttggtat  ttcaccggt  cccgtgtct  ctttgtcca  gagggttat  aaggcctgg  180
ggatggtgg  gatcacatc  aggaagcca  ctgggagag  gtttcgatg  tgcttcagc  240
gggaggcac  gtgattgga  gtgcccggt  caaggactt  cgggaacga  aaggacgac  300
ccgagctgc  tacaacctg  tgaagcgtg  gatcaccaa  ctctgtgtc  ttgggggtg  360
tggcagcct  actggggct  acaccttcc  ttctgagtg  agtgacttg  tgagtgacc  420
ccagaaagc  ggtaagatc  cagatgagg  ggctacgaa  tccagctac  tgaacattg  480
gggcctggt  gggtcaatt  acaatgact  ctgtggcac  gatatgacc  ttggcactg  540
ctctgccct  catcggatc  tggaaattg  agatgccat  actaccact  cccagagcc  600
ccagaggac  tttgtgtta  aagtaatgg  ccgccactg  ggatacctg  cccttgtca  660
ctctctgtc  tgtggggcc  actgggttt  tattcctga  tgtccacca  atgacgact  720
ggaggaaca  ctttgtcgc  gactcagcg  gacaaggac  cgtggttct  gtctcaaca  780
catcattgt  gctgagggt  caattgaca  gaatggaaa  ccaatcacc  cagaagaca  840
caagaatgg  agcaggatg  gtgtggaag  agtgatggc  cttttggag  ggaccccag  900
taccccagc  tgtgtagtg  gcctctctg  taaccaggc  gtgcgcctg  ccctcatgg  960
atgtgtcca  gtgaccaaa  atgtgacca  ggccatgga  gagaagaaa  ttgacgaag  1020
cctgaagct  agaggccgg  gcttcatga  caactggga  gtgtacaag  ttctagctc  1080
tgtcagacc  ccggtatct  agagtggtt  gcacacagt  gctgtgatg  acgtggggg  1140
tccggctgc  ggcatgaat  ctgctgttc  ctccactgt  aggattggc  ttatccagg  1200
caaccgagt  ctcgttgtc  atgatggtt  cgagggcct  gccaagggg  agatagagg  1260
agctggctg  agctatgtt  ggggctgga  tggccaagg  ggctctaaa  ttgggacta  1320
aaggactct  cccaagaag  gctttgaac  gatcagtgc  aatataact  agtttaaca  1380
tcagggcct  gtcatcatt  ggggctttg  ggcttacac  gggggcctg  aactgatgg  1440
gggcaggaa  cagtttgat  agctctgca  cccatttgt  gtcattcct  ctacagtct  1500
caacaatgt  cctggctca  acttcagcg  tggggctga  acagcactc  atactatct  1560
cacaacctg  gaccgcatc  agcagtcag  agctggcac  aagcgtcgg  tgtttatca  1620
tgagactat  ggtggctac  gtggctacc  ggctaccat  gctggactg  cagctgggg  1680
cgatgctgc  tacattttt  aggagccct  caccattcg  gacctgcag  caaatgttg  1740
acatctggt  caaaagatg  aaacaactg  gaaaagggg  ttggtgtta  ggaatgaaa  1800
gtgcaatga  aactatacc  ctgacttca  tttcaacct  tactctgag  aggggaagg  1860
catcttcga  agcaggaag  atgtgcttg  tcacatgca  cagggtggg  gcccaaccc  1920
atttgatag  aattttgcc  ctaagatgg  cgccaaggc  atgaactgg  tgtctggga  1980
aatcaaaga  agttaccgt  atgggcgga  ctttgccaa  actccagat  cgggctgtg  2040
tctggggat  cgtaagagg  ctctggtct  ccaaccagt  gctgagctg  aggaccaga  2100
agattttga  catcgaatc  ccaaggaac  gtggtggct  aaactgagg  ccatcctca  2160
aatcctagc  aagtacgag  ttgacttgg  cacttcaga  catgcccac  tggagcaca  2220
cacccggaa  cggtccggg  aagcggccg  ctaaacctc  ctggagtga  gggaataga  2280
tacctgatc  tggtcagct  acaccctaa  aagtccaca  cttctcagt  ttttagctg  2340
ttttttcat  aggtttcct  ttattctgt  ccttgcagc  atgaccagt  ctggccagg  2400
gctggagga  caggcagtg  gtgggagct  cttttaggt  gaatttaac  tgacttctg  2460
cccagcttt  tctgtcaca  aaggctggg  acctctagt  ctactgcta  atatcactt  2520
ctcagttag  attttccta  aaataagct  tatttattt  tttgtgata  caaagagtc  2580
tggttcctc  actactttt  ctacagtga  aaattgtaa  tacactaat  aatgccaac  2640
ggtcactgt  aaaaaaaaa  aaaaaaaaaa  2670



<210> 1844
<211> 779
<212> PRT
<213> Homo sapiens
<308> P08237
<400> 1844

Thr His Glu Glu His His Ala Ala Lys Thr Leu Gly Ile Gly Lys Ala 
  1               5                  10                  15
Ile Ala Val Leu Thr Ser Gly Gly Asp Ala Gln Gly Met Asn Ala Ala 
             20                  25                  30
Val Arg Ala Val Val Arg Val Gly Ile Phe Thr Gly Ala Arg Val Phe 
         35                  40                  45
Phe Val His Glu Gly Tyr Gln Gly Leu Val Asp Gly Gly Asp His Ile 
     50                  55                  60
Lys Glu Ala Thr Trp Glu Ser Val Ser Met Met Leu Gln Leu Gly Gly 
 65                  70                  75                  80
Thr Val Ile Gly Ser Ala Arg Cys Lys Asp Phe Arg Glu Arg Glu Gly 
                 85                  90                  95
Arg Leu Arg Ala Ala Tyr Asn Leu Val Lys Arg Gly Ile Thr Asn Leu 
             100                105                110
Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala Asp Thr Phe Arg 
         115                120                125
Ser Glu Trp Ser Asp Leu Leu Ser Asp Leu Gln Lys Ala Gly Lys Ile 
     130                135                140
Thr Asp Glu Glu Ala Thr Lys Ser Ser Tyr Leu Asn Ile Val Gly Leu 
 145                150                155                160
Val Gly Ser Ile Asp Asn Asp Phe Cys Gly Thr Asp Met Thr Ile Gly 
                 165                170                175
Thr Asp Ser Ala Leu His Arg Ile Met Glu Ile Val Asp Ala Ile Thr 
             180                185                190
Thr Thr Ala Gln Ser His Gln Arg Thr Phe Val Leu Glu Val Met Gly 
         195                200                205
Arg His Cys Gly Tyr Leu Ala Leu Val Thr Ser Leu Ser Cys Gly Ala 
     210                215                220
Asp Trp Val Phe Ile Pro Glu Cys Pro Pro Asp Asp Asp Trp Glu Glu 
 225                230                235                240
His Leu Cys Arg Arg Leu Ser Glu Thr Arg Thr Arg Gly Ser Arg Leu 
                 245                250                255
Asn Ile Ile Ile Val Ala Glu Gly Ala Ile Asp Lys Asn Gly Lys Pro 
             260                265                270
Ile Thr Ser Glu Asp Ile Lys Asn Leu Val Val Lys Arg Leu Gly Tyr 
         275                280                285
Asp Thr Arg Val Thr Val Leu Gly His Val Gln Arg Gly Gly Thr Pro 
     290                295                300
Ser Ala Phe Asp Arg Ile Leu Gly Ser Arg Met Gly Val Glu Ala Val 
 305                310                315                320
Met Ala Leu Leu Glu Gly Thr Pro Asp Thr Pro Ala Cys Val Val Ser 
                 325                330                335
Leu Ser Gly Asn Gln Ala Val Arg Leu Pro Leu Met Glu Cys Val Gln 
             340                345                350
Val Thr Lys Asp Val Thr Lys Ala Met Asp Glu Lys Lys Phe Asp Glu 
         355                360                365
Ala Leu Lys Leu Arg Gly Arg Ser Phe Met Asn Asn Trp Glu Val Tyr 
     370                375                380
Lys Leu Leu Ala His Val Arg Pro Pro Val Ser Lys Ser Gly Ser His 
 385                390                395                400
Thr Val Ala Val Met Asn Val Gly Ala Pro Ala Ala Gly Met Asn Ala 
                 405                410                415
Ala Val Arg Ser Thr Val Arg Ile Gly Leu Ile Gln Gly Asn Arg Val 
             420                425                430
Leu Val Val His Asp Gly Phe Glu Gly Leu Ala Lys Gly Gln Ile Glu 
         435                440                445
Glu Ala Gly Trp Ser Tyr Val Gly Gly Trp Thr Gly Gln Gly Gly Ser 
     450                455                460
Lys Leu Gly Thr Lys Arg Thr Leu Pro Lys Lys Ser Phe Glu Gln Ile 
 465                470                475                480
Ser Ala Asn Ile Thr Lys Phe Asn Ile Gln Gly Leu Val Ile Ile Gly 
                 485                490                495
Gly Phe Glu Ala Tyr Thr Gly Gly Leu Glu Leu Met Glu Gly Arg Lys 
             500                505                510
Gln Phe Asp Glu Leu Cys Ile Pro Phe Val Val Ile Pro Ala Thr Val 
         515                520                525
Ser Asn Asn Val Pro Gly Ser Asp Phe Ser Val Gly Ala Asp Thr Ala 
     530                535                540
Leu Asn Thr Ile Cys Thr Thr Cys Asp Arg Ile Lys Gln Ser Ala Ala 
 545                550                555                560
Gly Thr Lys Arg Arg Val Phe Ile Ile Glu Thr Met Gly Gly Tyr Cys 
                 565                570                575
Gly Tyr Leu Ala Thr Met Ala Gly Leu Ala Ala Gly Ala Asp Ala Ala 
             580                585                590
Tyr Ile Phe Glu Glu Pro Phe Thr Ile Arg Asp Leu Gln Ala Asn Val 
         595                600                605
Glu His Leu Val Gln Lys Met Lys Thr Thr Val Lys Arg Gly Leu Val 
     610                615                620
Leu Arg Asn Glu Lys Cys Asn Glu Asn Tyr Thr Thr Asp Phe Ile Phe 
 625                630                635                640
Asn Leu Tyr Ser Glu Glu Gly Lys Gly Ile Phe Asp Ser Arg Lys Asn 
                 645                650                655
Val Leu Gly His Met Gln Gln Gly Gly Ser Pro Thr Pro Phe Asp Arg 
             660                665                670
Asn Phe Ala Thr Lys Met Gly Ala Lys Ala Met Asn Trp Met Ser Gly 
         675                680                685
Lys Ile Lys Glu Ser Tyr Arg Asn Gly Arg Ile Phe Ala Asn Thr Pro 
     690                695                700
Asp Ser Gly Cys Val Leu Gly Met Arg Lys Arg Ala Leu Val Phe Gln 
 705                710                715                720
Pro Val Ala Glu Leu Lys Asp Gln Thr Asp Phe Glu His Arg Ile Pro 
                 725                730                735
Lys Glu Gln Trp Trp Leu Lys Leu Arg Pro Ile Leu Lys Ile Leu Ala 
             740                745                750
Lys Tyr Glu Ile Asp Leu Asp Thr Ser Asp His Ala His Leu Glu His 
         755                760                765
Ile Thr Arg Lys Arg Ser Gly Glu Ala Ala Val 
     770                775



<210> 1845
<211> 4432
<212> DNA
<213> Rattus norvegicus
<308> D25233
<400> 1845

ccggaggac  accccgcgc  ggacagtga  cccgaagag  tgcccctga  caggcttga  60
tttgaaaaa  ttgaagaac  tgaatttat  gcattatgt  agaagttaa  ggtgcccga  120
catgtcaga  agagagctt  gctaacgtg  gagaaagtt  catctgtgg  tggaatcct  180
gaaggatat  ttcagaaga  gaaggaact  tggggcatc  gcatcttca  tgcagcagt  240
gacctggat  agatgccat  cacttttac  gagcttcag  aaagcatag  aaccagtgt  300
tataaattc  ttgacttat  aaaagaaat  gataccagt  ccaaagttg  taatgctgt  360
tcaaggcta  tgaagaagt  caatgtgtt  tgtgcactc  acagcaaat  agaacggac  420
tgtggactt  tatatttga  acagcccag  agtgggtta  ctactgaaa  aaattctat  480
ttggtgcta  aagtttctt  gatcacctt  ttactagct  aaggagaag  agtacagat  540
gaagatgat  tggtgatct  atttcagtt  atgttgtgt  tacttgact  ttttatcaa  600
ctctcgcct  ctgcgctgc  cagagagcc  tacaaaaca  ctgcaacac  cattaatgg  660
tcacctcgg  cacccagaa  aggtcagaa  aggagtgct  ggatagcaa  acaactaga  720
agtgataca  gaactattg  agttctctg  aaggagcac  agtgtaatg  agatgaggt  780
aaaaatgtt  atttcaaaa  ttttatccc  tttataagt  cacttggaa  tgtatcatc  840
aatggactt  cagagcttg  aagtctttc  aaacgctac  aagaagttt  tcttaaaag  900
aaagattta  atgcaagac  atttttgga  catgacaaa  cacttcaga  tgatactat  960
gacagtttt  aaacagaga  aactccacg  aaaagcaac  ctgatgaag  ggcaaacat  1020
gttactcca  acactccag  taggactgt  atgaatact  ttcaacagt  aatggtgat  1080
ttaaattct  caagtgatc  gccatcaga  aatctgatt  cctacttca  taattgcac  1140
gtgaatcca  aagaaaata  cctaaaaag  gtaaaggat  ttggacaca  ctttaaaga  1200
aagtttgct  gcgctgtgg  gcagggatg  attgacatt  gagcacagc  atataaact  1260
ggggttcga  tgtattatc  tgtgatgga  tcgatgctt  aatcagaag  agaacgttt  1320
tccattcag  attttagca  actcctaaa  gacaacatc  ttcatatgt  tttattggc  1380
tgtgctctt  aagttgtaa  ggctacata  agcaggagt  tgttacaga  tcttgattc  1440
ggaacagat  tgtccttcc  gtggattct  aatgtactt  atttaaaag  ctttgattt  1500
tacaaagtg  ttgaaagtt  tatcaaagt  gaagccaac  tgacaagag  aatgataaa  1560
catttagaa  gatgtgagc  tcgaatcat  gaatccctt  catggcttt  tgattcacc  1620
ttgtttgat  tcataaagc  gtccaagga  ggggaagga  ctgatcacc  tgagtctgc  1680
tgttctctc  gcctccctc  ccagagtaa  cacactgca  cagatatgt  tctttctcc  1740
ataagatct  caaagaaaa  aacttctac  acacgtgta  attctgcgg  aaatacaga  1800
acgcaagca  cctcagcct  ccatactca  aagccattg  aatctacct  cctttccct  1860
ttttacaaa  aagtgtacc  tctagcata  ctccgacta  atacactgt  tgcgcgcct  1920
ctgtctgac  acccagagc  agaacacat  atctggact  tgtttcagc  tacattgga  1980
aatgagtat  agctcatga  agaccgaca  ttggaccag  ttatgatgt  ttctatgta  2040
ggcatctgc  aggtgaaaa  cattgacct  aaattcaaa  tcatcgtaa  tgcgtataa  2100
gatcttcct  acgctgccc  ggagacctt  aaacgtgtt  tgatcagag  agaggagtt  2160
gattccatt  tagtgttct  caactcagt  ttcatgcag  gactaaaaa  aaatatttt  2220
cagtatgcc  ccaccaggc  tcctacctt  tcaccaata  ctcacattc  tcgaagccc  2280
tacaagttc  cgagttcac  cttgcggat  cctggaggt  acatctata  gtcacccct  2340
aagagtcct  ataaaattt  agaaggtct  ccaacaccc  caaaaatga  tccaagatc  2400
agaatcttg  tctcaatcg  tgaatcatt  gggacatcc  agaagttcc  gaaaataaa  2460
cagatggtg  gtaacagtg  cagagtgct  aaaagaagt  ctgaaggcg  caatccccc  2520
aaacccctg  agaagctgc  ctttgacat  gaaggatcc  atgaagcag  cgggagtaa  2580
catctccca  cggagtcca  attccaaca  aaactggca  aaatgactt  tactcgaac  2640
cgaatgcaa  agcagaaac  gaatgatag  atggaaatc  caaacaagg  ggaaaagtg  2700
tgatctcag  accctaaca  tgtagaccc  cgggacacc  gactcgtgt  tcatggatg  2760
gactatagt  cccaggttc  gctcatgtt  tagatataa  atgtgcagg  acagctgaa  2820
atttatgtg  gtgatttgt  agccacttc  atgttgtaa  caatggtat  gaattgaca  2880
tacacagga  tgagaatct  gtgcagatc  tgccattta  aatatgaaa  cagattgtt  2940
gcatttcca  caggagcct  ctgccctca  aagtgaggc  gcctctgga  ggagtccta  3000
caactccct  acatctggc  gactacttt  cctttcctt  tggcacatg  gtgatgttt  3060
ctcttggtt  tattaattt  tatgtattt  ttaatttaa  gtgaatatc  ttagaaaat  3120
tgtcttgtc  tccaaatgc  agttgattg  ttgtccaca  tcaaccaaa  tatcttgaa  3180
cctctactg  aacagattg  tacaaactg  ggaaaagta  taatttgta  acattggac  3240
tgttttaat  ctagaatct  atgtgccat  tgtttgttt  acacatttt  cctttgaaa  3300
agaagtaaa  aaagtataa  catatgata  tgtcttact  ctgacacag  tttcatacc  3360
cagaccctc  aagaaccaa  tcttttatt  atccaactc  tactttaaa  tgaagacta  3420
tgataatac  ccaggtttg  tttttcttt  aatctttca  atcactgaa  ctttaagta  3480
ccatgtagt  cttgaaaat  aagtctggc  acaactgta  ttcagagga  cctagtaca  3540
tacaaccca  gtgcacttt  taatgtctc  gggtcctga  gaatcaaga  acaaattaa  3600
tatgttctg  aagcagacc  ttaactata  gagccttcg  tttaactat  ttctgtaag  3660
agaccgtta  ctataggag  cttcggttt  ccctcatac  agtgtctaa  cacatctca  3720
cagttcact  tgctcttct  catccaggg  tgatgtgtt  cctctggaa  ggtacatgt  3780
ttccagggt  ttttgaact  gcaggtatc  attttttta  gccaatctg  tctaataac  3840
ctggcttct  caaagccac  gcatttcta  tccagctgt  ccgaagctt  agactaaaa  3900
agctgcatt  aaagaagag  cactccctt  acccccccc  cccacctaa  ggtgtttac  3960
ttatcttgt  ggattaact  atttagaga  gctataatt  aaaataggc  gtatttaag  4020
tagcgtcag  tagcattta  gaaaatcat  ttttctaaa  tccatactt  ttgaaaaga  4080
atctggtct  gttagaaaa  aaatttcta  tttgtcctc  atttagttt  agttttact  4140
ggttgatag  tatctcgat  acaaaggcc  tagacagct  cccccattt  ttcattgag  4200
tttgcatgg  catcacaca  gttagttgg  tttaggtca  gggctgacc  tacttctag  4260
tcttttgct  gtaagttca  gttagaatt  gtgacagaa  cataggaat  ttcagagat  4320
ctctattaa  atttcttaa  actgcagac  ctgcttttg  ttttgtact  gttaaaact  4380
tacattcag  ttgctatgt  cctattttc  ataatagtt  gtctatttt  ca  4432



<210> 1846
<211> 899
<212> PRT
<213> Rattus norvegicus
<308> P33568
<400> 1846

Pro Glu Asp Asp Pro Ala Gln Asp Ser Asp Pro Glu Glu Leu Pro Leu 
  1               5                  10                  15
Ile Arg Leu Glu Phe Glu Lys Ile Glu Glu Pro Glu Phe Ile Ala Leu 
             20                  25                  30
Cys Gln Lys Leu Lys Val Pro Asp His Val Arg Glu Arg Ala Trp Leu 
         35                  40                  45
Thr Trp Glu Lys Val Ser Ser Val Asp Gly Ile Leu Glu Gly Tyr Ile 
     50                  55                  60
Gln Lys Lys Lys Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val 
 65                  70                  75                  80
Asp Leu Asp Glu Met Pro Phe Thr Phe Thr Glu Leu Gln Lys Ser Ile 
                 85                  90                  95
Glu Thr Ser Val Tyr Lys Phe Phe Asp Leu Leu Lys Glu Ile Asp Thr 
             100                105                110
Ser Thr Lys Val Asp Asn Ala Val Ser Arg Leu Leu Lys Lys Tyr Asn 
         115                120                125
Val Leu Cys Ala Leu Tyr Ser Lys Leu Glu Arg Thr Cys Gly Leu Ile 
     130                135                140
Tyr Leu Thr Gln Pro Ser Ser Gly Leu Ser Thr Glu Ile Asn Ser Met 
 145                150                155                160
Leu Val Leu Lys Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu 
                 165                170                175
Val Val Gln Met Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu 
             180                185                190
Cys Val Leu Asp Tyr Phe Ile Lys Leu Ser Pro Pro Ala Leu Leu Arg 
         195                200                205
Glu Pro Tyr Lys Thr Ala Ala Thr Pro Ile Asn Gly Ser Pro Arg Thr 
     210                215                220
Pro Arg Arg Gly Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu 
 225                230                235                240
Ser Asp Thr Arg Thr Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn 
                 245                250                255
Val Asp Glu Val Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Ile 
             260                265                270
Ser Ser Leu Gly Ile Val Ser Ser Asn Gly Leu Pro Glu Leu Glu Ser 
         275                280                285
Leu Ser Lys Arg Tyr Glu Glu Val Tyr Leu Lys Ser Lys Asp Leu Asp 
     290                295                300
Ala Arg Leu Phe Leu Asp His Asp Lys Thr Leu Gln Thr Asp Thr Ile 
 305                310                315                320
Asp Ser Phe Glu Thr Glu Arg Thr Pro Arg Lys Ser Asn Pro Asp Glu 
                 325                330                335
Glu Ala Asn Met Val Thr Pro His Thr Pro Val Arg Thr Val Met Asn 
             340                345                350
Thr Ile Gln Gln Leu Met Val Ile Leu Asn Ser Ala Ser Asp Gln Pro 
         355                360                365
Ser Glu Asn Leu Ile Ser Tyr Phe Ser Asn Cys Thr Val Asn Pro Lys 
     370                375                380
Glu Asn Ile Leu Lys Arg Val Lys Asp Val Gly His Ile Phe Lys Glu 
 385                390                395                400
Lys Phe Ala Ser Ala Val Gly Gln Gly Cys Ile Asp Ile Gly Ala Gln 
                 405                410                415
Arg Tyr Lys Leu Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met 
             420                425                430
Leu Lys Ser Glu Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu 
         435                440                445
Leu Asn Asp Asn Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu 
     450                455                460
Val Val Met Ala Thr Tyr Ser Arg Ser Met Leu Gln Asn Leu Asp Ser 
 465                470                475                480
Gly Thr Asp Leu Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys 
                 485                490                495
Ala Phe Asp Phe Tyr Lys Val Ile Glu Ser Phe Ile Lys Val Glu Ala 
             500                505                510
Asn Leu Thr Arg Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg 
         515                520                525
Ile Met Glu Ser Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu 
     530                535                540
Ile Lys Gln Ser Lys Asp Gly Glu Gly Pro Asp His Leu Glu Ser Ala 
 545                550                555                560
Cys Ser Leu Ser Leu Pro Leu Gln Ser Asn His Thr Ala Ala Asp Met 
                 565                570                575
Tyr Leu Ser Pro Ile Arg Ser Pro Lys Lys Arg Thr Ser Thr Thr Arg 
             580                585                590
Val Asn Ser Ala Ala Asn Thr Glu Thr Gln Ala Ala Ser Ala Phe His 
         595                600                605
Thr Gln Lys Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys 
     610                615                620
Val Tyr Arg Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Ala Arg Leu 
 625                630                635                640
Leu Ser Asp His Pro Glu Pro Glu His Ile Ile Trp Thr Leu Phe Gln 
                 645                650                655
His Thr Leu Glu Asn Glu Tyr Glu Leu Met Lys Asp Arg His Leu Asp 
             660                665                670
Gln Ile Met Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile 
         675                680                685
Asp Leu Lys Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His 
     690                695                700
Ala Ala Gln Glu Thr Phe Lys Arg Val Leu Ile Arg Glu Glu Glu Phe 
 705                710                715                720
Asp Ser Ile Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys 
                 725                730                735
Thr Asn Ile Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro 
             740                745                750
Ile Pro His Ile Pro Arg Ser Pro Tyr Lys Phe Ser Ser Ser Pro Leu 
         755                760                765
Arg Ile Pro Gly Gly Asn Ile Tyr Met Ser Pro Leu Lys Ser Pro Tyr 
     770                775                780
Lys Ile Ser Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser 
 785                790                795                800
Arg Ile Leu Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe 
                 805                810                815
Gln Lys Ile Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg 
             820                825                830
Ser Ala Glu Gly Gly Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe 
         835                840                845
Asp Ile Glu Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Ala 
     850                855                860
Glu Ser Lys Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr 
 865                870                875                880
Arg Met Gln Lys Gln Lys Leu Asn Asp Ser Met Glu Ile Ser Asn Lys 
                 885                890                895
Glu Glu Lys 
             900



<210> 1847
<211> 4839
<212> DNA
<213> Homo sapiens
<308> L41870
<400> 1847

tccggtttt  ctcagggga  gttgaaatt  tttttgtaa  gggagtcgg  agaggacgg  60
gcgtgcccc  cgtgcgcgc  cgtcgtcct  cccggcgct  ctccacagc  cgctggctc  120
cgccgcgga  aggcgtcat  ccgcccaaa  ccccccgaa  aacggccgc  accgccgcc  180
ctgccgccg  ggaaccccc  gcaccgccg  cgccgcccc  tcctgagga  gacccagag  240
aggacagcg  cccggagga  ctgcctctc  tcaggcttg  gtttgaaga  acagaagaa  300
ctgatttta  tgcattatg  cagaaatta  agataccag  tcatgtcag  gagagagct  360
ggttaactt  ggagaaagt  tcatctgtg  atggagtat  gggaggtta  attcaaaag  420
aaaaggaac  gtggggaat  tgtatcttt  ttgcagcag  tgacctaga  gagatgtcg  480
tcactttta  tgagctaca  aaaaacata  aaatcagtg  ccataaatt  tttaactta  540
taaaagaaa  tgataccag  accaaagtt  ataatgcta  gtcaagact  ttgaagaag  600
atgatgtat  gtttgcact  ttcagcaaa  tggaaagga  atgtgaact  atatatttg  660
cacaaccca  cagttcgat  tctactgaa  taaattctg  attggtgct  aaagtttct  720
ggatcacat  tttattagc  aaaggggaa  tattacaaa  ggaagatga  ctggtgatt  780
catttcagt  aatgctatg  gtccttgac  attttatta  actctcacc  cccatgttg  840
tcaaagaac  atataaaac  gctgttata  ccattaatg  ttcacctcg  acacccagg  900
gaggtcaga  caggagtgc  cggatagca  aacaactag  aaatgatac  agaattatt  960
aagttctct  taaagaaca  gaatgtaat  tagatgagg  gaaaaatgt  tatttcaaa  1020
attttatac  ttttatgaa  tctcttgga  ttgtaacat  taatggact  ccagaggtt  1080
aaaatcttt  taaacgata  gaagaaatt  atcttaaaa  taaagatct  gatgcaaga  1140
tatttttgg  tcatgataa  actcttcag  ctgattcta  agacagttt  gaaacacag  1200
gaacaccac  aaaaagtaa  cttgatgaa  aggtgaatg  aattcctcc  cacactcca  1260
ttaggactg  tatgaacac  atccaacaa  taatgatga  tttaaattc  gcaagtgat  1320
aaccttcag  aaatctgat  tcctatttt  acaactgca  agtgaatcc  aaagaaagt  1380
tactgaaaa  agtgaagga  ataggatac  tctttaaag  gaaatttgc  aaagctgtg  1440
gacagggtt  tgtcgaaat  ggatcacag  gatacaaac  tggagttcg  ttgtattac  1500
gagtaatgg  atccatgct  aaatcagaa  aagaacgat  atccattca  aattttagc  1560
aacttctga  tgacaacat  tttcatatg  ctttattgg  gtgcgctct  gaggttgta  1620
tggccacat  tagcagaag  acatctcag  atcttgatt  tggaacaga  ttgtctttc  1680
catggattc  gaatgtgct  aatttaaaa  cctttgatt  ttacaaagt  atcgaaagt  1740
ttatcaaag  agaaggcaa  ttgacaaga  aaatgataa  acatttaga  cgatgtgaa  1800
atcgaatca  ggaatccct  gcatggctc  cagattcac  tttatttga  cttattaaa  1860
aatcaaagg  ccgagaagg  ccaactgat  accttgaat  tgcttgtcc  cttaatctt  1920
ctctccaga  taatcacac  gcagcagat  tgtatcttt  tcctgtaag  tctccaaag  1980
aaaaaggtt  aactacgcg  gtaaattct  ctgcaaatg  agagacaca  gcaacctca  2040
ccttccaga  ccagaagcc  ttgaaatct  cctctcttt  actgtttta  aaaaaagtg  2100
atcggctag  ctatctccg  ctaaataca  tttgtgaac  ccttctgtc  gagcaccca  2160
aattagaac  tatcatctg  acccttttc  agcacaccc  gcagaatga  tatgaactc  2220
tgagagaca  gcatttgga  caaattatg  tgtgttcca  gtatggcat  tgcaaagtg  2280
agaatatag  ccttaaatt  aaaatcatt  taacagcat  caaggatct  cctcatgct  2340
ttcaggaga  attcaaacg  gttttgatc  aagaagagg  gtatgattc  attatagta  2400
tctataact  ggtcttcat  cagagactg  aaacaaata  tttgcagta  gcttccacc  2460
ggcccccta  cttgtcacc  atacctcac  ttcctcgaa  cccttacaa  tttcctagt  2520
cacccttac  gattcctgg  gggaacatc  atatttcac  cctgaagag  ccatataaa  2580
tttcagaag  tctgccaac  ccaacaaaa  tgactccaa  atcaagaat  ttagtatca  2640
ttggtgaat  attcgggac  tctgagaag  tccagaaaa  aaatcagat  gtatgtaac  2700
gcgaccgtg  gctcaaaag  agtgctgaa  gaagcaacc  tcctaaacc  ctgaaaaaa  2760
tacgctttg  tattgaagg  tcagatgaa  cagatggaa  taaacatct  ccaggagag  2820
ccaaatttc  gcagaaact  gcagaaatg  cttctactc  aacacgaat  caaaagcag  2880
aaatgaatg  tagcatgga  acctcaaac  aggaagaga  atgaggatc  caggacctt  2940
gtggacact  tgtacacct  tggattcat  gtctctcac  gatgtgact  tataacttt  3000
ccaggttct  tttatggcc  catttaata  cttcagctc  ttttgtgga  ataaaatgt  3060
cagatgcaa  tgtttgggt  attcctaag  cacttgaaa  gttagtcat  gttatttat  3120
caagattga  aatcttgtg  aaatcctgc  atttaaaaa  ttgtagcag  ttgtttcct  3180
ttccaaagt  aaattgctg  gctttatgg  tagtaagaa  ggccctaga  tgggagtcc  3240
gataaccca  gcctgtctg  ctactttgc  ttcttttgt  gcatatagg  gatgtttgc  3300
cttgttttt  ttaatttat  tgtatattt  tttaattta  catgaacac  cttagaaaa  3360
gtgtcctat  tatcttcca  atgcaattt  attgactgc  cattcacca  aattatcct  3420
aactcttct  caaaaatgg  tattattag  aattagaaa  aaattacta  ttttacaca  3480
tagatttta  tttactatt  gaatctgat  tactgtgtg  ttgttttat  aaattttgc  3540
tttaattaa  taaaagctg  aagcaaagt  taaccatat  atactatca  actactgaa  3600
cagatttca  acctcagaa  gtaaaagaa  ttactgatt  ttttcttca  ccaacttat  3660
tttttaaat  aggattatt  atagtactc  tggttttta  accattcag  tcactgaat  3720
tataaagta  ccatctagt  cttgaaaaa  taaagtgtt  tgccagatc  taggtatag  3780
ggaccctaa  acagtatat  ccaagtgca  tttctaatg  ttctgggtc  tgaagaatt  3840
agatacaaa  taattttac  ccataaaca  actgttaat  ataggagcc  taatttttt  3900
ttcatagag  tttgtctaa  tgcatctca  aattattct  ccctcctta  tttgggaag  3960
tttgtgttt  ctctggaat  gtacatgtc  tccatgtat  ttttgaact  gcaattgtc  4020
atttatctt  tattttttt  agtcagtat  gtctaacac  ggcatgttc  aagccacat  4080
atttctagt  caaaattac  agtaatcaa  ggtcattat  ggttaggca  taatgtttc  4140
atctgattt  gtgcaaaag  ttcaaatta  aacagctgc  ttagaaaaa  aggcgcttc  4200
cccctcccc  acacctaaa  gtgtattta  actatcttg  gtgattaac  tatttagag  4260
tgctgtaac  taaaatagg  gatatttaa  gtagcttca  ctagctttt  ggaaaatca  4320
tttgtctaa  tcagaatta  ttttaaaaa  aaatctggt  ttgttagaa  acaaaattt  4380
attttgtgc  catttaagt  tcaaactta  tattttgac  gttattttg  taacaatga  4440
actagaaaa  ttgactcca  ttcatcatt  tttctgcat  aatatcata  aaatcagtt  4500
gtttttagg  caagggctt  ctatttctg  gtcttttgc  actaagttc  cattagaat  4560
agtgccaga  ttttaggaa  ttcagagat  gtgtattga  atttcttaa  taatgcttc  4620
gatattatt  ctttattgc  tttttgtat  ggttaaaac  gtacattta  aattgctat  4680
ttactattt  ctacaatta  tagtttgtc  attttaaaa  aaattagtt  ttaagagtc  4740
taatggtct  atgttgtgt  ctttgtatt  agtacacta  tgttctctt  tctgtctag  4800
agaagatag  tagaagata  ctctcctag  atctcatcc  4839



<210> 1848
<211> 928
<212> PRT
<213> Homo sapiens
<308> P06400
<400> 1848

Met Pro Pro Lys Thr Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala 
  1               5                  10                  15
Ala Ala Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp 
             20                  25                  30
Pro Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu 
         35                  40                  45
Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu 
     50                  55                  60
Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys 
 65                  70                  75                  80
Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys Lys Lys 
                 85                  90                  95
Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val Asp Leu Asp Glu 
             100                105                110
Met Ser Phe Thr Phe Thr Glu Leu Gln Lys Asn Ile Glu Ile Ser Val 
         115                120                125
His Lys Phe Phe Asn Leu Leu Lys Glu Ile Asp Thr Ser Thr Lys Val 
     130                135                140
Asp Asn Ala Met Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala 
 145                150                155                160
Leu Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln 
                 165                170                175
Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys 
             180                185                190
Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met 
         195                200                205
Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val Leu Asp 
     210                215                220
Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys Glu Pro Tyr Lys 
 225                230                235                240
Thr Ala Val Ile Pro Ile Asn Gly Ser Pro Arg Thr Pro Arg Arg Gly 
                 245                250                255
Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg 
             260                265                270
Ile Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val 
         275                280                285
Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly 
     290                295                300
Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg 
 305                310                315                320
Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe 
                 325                330                335
Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp Ser Phe Glu 
             340                345                350
Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp Glu Glu Val Asn Val 
         355                360                365
Ile Pro Pro His Thr Pro Val Arg Thr Val Met Asn Thr Ile Gln Gln 
     370                375                380
Leu Met Met Ile Leu Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu 
 385                390                395                400
Ile Ser Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu 
                 405                410                415
Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys 
             420                425                430
Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu 
         435                440                445
Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser Glu 
     450                455                460
Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn 
 465                470                475                480
Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu Val Val Met Ala 
                 485                490                495
Thr Tyr Ser Arg Ser Thr Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu 
             500                505                510
Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe 
         515                520                525
Tyr Lys Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg 
     530                535                540
Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser 
 545                550                555                560
Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser 
                 565                570                575
Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys Pro Leu 
             580                585                590
Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp Met Tyr Leu Ser 
         595                600                605
Pro Val Arg Ser Pro Lys Lys Lys Gly Ser Thr Thr Arg Val Asn Ser 
     610                615                620
Thr Ala Asn Ala Glu Thr Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys 
 625                630                635                640
Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg 
                 645                650                655
Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu 
             660                665                670
His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu 
         675                680                685
Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met 
     690                695                700
Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp Leu Lys 
 705                710                715                720
Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His Ala Val Gln 
                 725                730                735
Glu Thr Phe Lys Arg Val Leu Ile Lys Glu Glu Glu Tyr Asp Ser Ile 
             740                745                750
Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile 
         755                760                765
Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His 
     770                775                780
Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro 
 785                790                795                800
Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile Ser 
                 805                810                815
Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser Arg Ile Leu 
             820                825                830
Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys Ile 
         835                840                845
Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala Glu 
     850                855                860
Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe Asp Ile Glu 
 865                870                875                880
Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys 
                 885                890                895
Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln 
             900                905                910
Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys 
         915                920                925



<210> 1849
<211> 4432
<212> DNA
<213> Rattus norvegicus
<308> D25233
<400> 1849

ccggaggac  accccgcgc  ggacagtga  cccgaagag  tgcccctga  caggcttga  60
tttgaaaaa  ttgaagaac  tgaatttat  gcattatgt  agaagttaa  ggtgcccga  120
catgtcaga  agagagctt  gctaacgtg  gagaaagtt  catctgtgg  tggaatcct  180
gaaggatat  ttcagaaga  gaaggaact  tggggcatc  gcatcttca  tgcagcagt  240
gacctggat  agatgccat  cacttttac  gagcttcag  aaagcatag  aaccagtgt  300
tataaattc  ttgacttat  aaaagaaat  gataccagt  ccaaagttg  taatgctgt  360
tcaaggcta  tgaagaagt  caatgtgtt  tgtgcactc  acagcaaat  agaacggac  420
tgtggactt  tatatttga  acagcccag  agtgggtta  ctactgaaa  aaattctat  480
ttggtgcta  aagtttctt  gatcacctt  ttactagct  aaggagaag  agtacagat  540
gaagatgat  tggtgatct  atttcagtt  atgttgtgt  tacttgact  ttttatcaa  600
ctctcgcct  ctgcgctgc  cagagagcc  tacaaaaca  ctgcaacac  cattaatgg  660
tcacctcgg  cacccagaa  aggtcagaa  aggagtgct  ggatagcaa  acaactaga  720
agtgataca  gaactattg  agttctctg  aaggagcac  agtgtaatg  agatgaggt  780
aaaaatgtt  atttcaaaa  ttttatccc  tttataagt  cacttggaa  tgtatcatc  840
aatggactt  cagagcttg  aagtctttc  aaacgctac  aagaagttt  tcttaaaag  900
aaagattta  atgcaagac  atttttgga  catgacaaa  cacttcaga  tgatactat  960
gacagtttt  aaacagaga  aactccacg  aaaagcaac  ctgatgaag  ggcaaacat  1020
gttactcca  acactccag  taggactgt  atgaatact  ttcaacagt  aatggtgat  1080
ttaaattct  caagtgatc  gccatcaga  aatctgatt  cctacttca  taattgcac  1140
gtgaatcca  aagaaaata  cctaaaaag  gtaaaggat  ttggacaca  ctttaaaga  1200
aagtttgct  gcgctgtgg  gcagggatg  attgacatt  gagcacagc  atataaact  1260
ggggttcga  tgtattatc  tgtgatgga  tcgatgctt  aatcagaag  agaacgttt  1320
tccattcag  attttagca  actcctaaa  gacaacatc  ttcatatgt  tttattggc  1380
tgtgctctt  aagttgtaa  ggctacata  agcaggagt  tgttacaga  tcttgattc  1440
ggaacagat  tgtccttcc  gtggattct  aatgtactt  atttaaaag  ctttgattt  1500
tacaaagtg  ttgaaagtt  tatcaaagt  gaagccaac  tgacaagag  aatgataaa  1560
catttagaa  gatgtgagc  tcgaatcat  gaatccctt  catggcttt  tgattcacc  1620
ttgtttgat  tcataaagc  gtccaagga  ggggaagga  ctgatcacc  tgagtctgc  1680
tgttctctc  gcctccctc  ccagagtaa  cacactgca  cagatatgt  tctttctcc  1740
ataagatct  caaagaaaa  aacttctac  acacgtgta  attctgcgg  aaatacaga  1800
acgcaagca  cctcagcct  ccatactca  aagccattg  aatctacct  cctttccct  1860
ttttacaaa  aagtgtacc  tctagcata  ctccgacta  atacactgt  tgcgcgcct  1920
ctgtctgac  acccagagc  agaacacat  atctggact  tgtttcagc  tacattgga  1980
aatgagtat  agctcatga  agaccgaca  ttggaccag  ttatgatgt  ttctatgta  2040
ggcatctgc  aggtgaaaa  cattgacct  aaattcaaa  tcatcgtaa  tgcgtataa  2100
gatcttcct  acgctgccc  ggagacctt  aaacgtgtt  tgatcagag  agaggagtt  2160
gattccatt  tagtgttct  caactcagt  ttcatgcag  gactaaaaa  aaatatttt  2220
cagtatgcc  ccaccaggc  tcctacctt  tcaccaata  ctcacattc  tcgaagccc  2280
tacaagttc  cgagttcac  cttgcggat  cctggaggt  acatctata  gtcacccct  2340
aagagtcct  ataaaattt  agaaggtct  ccaacaccc  caaaaatga  tccaagatc  2400
agaatcttg  tctcaatcg  tgaatcatt  gggacatcc  agaagttcc  gaaaataaa  2460
cagatggtg  gtaacagtg  cagagtgct  aaaagaagt  ctgaaggcg  caatccccc  2520
aaacccctg  agaagctgc  ctttgacat  gaaggatcc  atgaagcag  cgggagtaa  2580
catctccca  cggagtcca  attccaaca  aaactggca  aaatgactt  tactcgaac  2640
cgaatgcaa  agcagaaac  gaatgatag  atggaaatc  caaacaagg  ggaaaagtg  2700
tgatctcag  accctaaca  tgtagaccc  cgggacacc  gactcgtgt  tcatggatg  2760
gactatagt  cccaggttc  gctcatgtt  tagatataa  atgtgcagg  acagctgaa  2820
atttatgtg  gtgatttgt  agccacttc  atgttgtaa  caatggtat  gaattgaca  2880
tacacagga  tgagaatct  gtgcagatc  tgccattta  aatatgaaa  cagattgtt  2940
gcatttcca  caggagcct  ctgccctca  aagtgaggc  gcctctgga  ggagtccta  3000
caactccct  acatctggc  gactacttt  cctttcctt  tggcacatg  gtgatgttt  3060
ctcttggtt  tattaattt  tatgtattt  ttaatttaa  gtgaatatc  ttagaaaat  3120
tgtcttgtc  tccaaatgc  agttgattg  ttgtccaca  tcaaccaaa  tatcttgaa  3180
cctctactg  aacagattg  tacaaactg  ggaaaagta  taatttgta  acattggac  3240
tgttttaat  ctagaatct  atgtgccat  tgtttgttt  acacatttt  cctttgaaa  3300
agaagtaaa  aaagtataa  catatgata  tgtcttact  ctgacacag  tttcatacc  3360
cagaccctc  aagaaccaa  tcttttatt  atccaactc  tactttaaa  tgaagacta  3420
tgataatac  ccaggtttg  tttttcttt  aatctttca  atcactgaa  ctttaagta  3480
ccatgtagt  cttgaaaat  aagtctggc  acaactgta  ttcagagga  cctagtaca  3540
tacaaccca  gtgcacttt  taatgtctc  gggtcctga  gaatcaaga  acaaattaa  3600
tatgttctg  aagcagacc  ttaactata  gagccttcg  tttaactat  ttctgtaag  3660
agaccgtta  ctataggag  cttcggttt  ccctcatac  agtgtctaa  cacatctca  3720
cagttcact  tgctcttct  catccaggg  tgatgtgtt  cctctggaa  ggtacatgt  3780
ttccagggt  ttttgaact  gcaggtatc  attttttta  gccaatctg  tctaataac  3840
ctggcttct  caaagccac  gcatttcta  tccagctgt  ccgaagctt  agactaaaa  3900
agctgcatt  aaagaagag  cactccctt  acccccccc  cccacctaa  ggtgtttac  3960
ttatcttgt  ggattaact  atttagaga  gctataatt  aaaataggc  gtatttaag  4020
tagcgtcag  tagcattta  gaaaatcat  ttttctaaa  tccatactt  ttgaaaaga  4080
atctggtct  gttagaaaa  aaatttcta  tttgtcctc  atttagttt  agttttact  4140
ggttgatag  tatctcgat  acaaaggcc  tagacagct  cccccattt  ttcattgag  4200
tttgcatgg  catcacaca  gttagttgg  tttaggtca  gggctgacc  tacttctag  4260
tcttttgct  gtaagttca  gttagaatt  gtgacagaa  cataggaat  ttcagagat  4320
ctctattaa  atttcttaa  actgcagac  ctgcttttg  ttttgtact  gttaaaact  4380
tacattcag  ttgctatgt  cctattttc  ataatagtt  gtctatttt  ca  4432



<210> 1850
<211> 899
<212> PRT
<213> Rattus norvegicus
<308> P33568
<400> 1850

Pro Glu Asp Asp Pro Ala Gln Asp Ser Asp Pro Glu Glu Leu Pro Leu 
  1               5                  10                  15
Ile Arg Leu Glu Phe Glu Lys Ile Glu Glu Pro Glu Phe Ile Ala Leu 
             20                  25                  30
Cys Gln Lys Leu Lys Val Pro Asp His Val Arg Glu Arg Ala Trp Leu 
         35                  40                  45
Thr Trp Glu Lys Val Ser Ser Val Asp Gly Ile Leu Glu Gly Tyr Ile 
     50                  55                  60
Gln Lys Lys Lys Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val 
 65                  70                  75                  80
Asp Leu Asp Glu Met Pro Phe Thr Phe Thr Glu Leu Gln Lys Ser Ile 
                 85                  90                  95
Glu Thr Ser Val Tyr Lys Phe Phe Asp Leu Leu Lys Glu Ile Asp Thr 
             100                105                110
Ser Thr Lys Val Asp Asn Ala Val Ser Arg Leu Leu Lys Lys Tyr Asn 
         115                120                125
Val Leu Cys Ala Leu Tyr Ser Lys Leu Glu Arg Thr Cys Gly Leu Ile 
     130                135                140
Tyr Leu Thr Gln Pro Ser Ser Gly Leu Ser Thr Glu Ile Asn Ser Met 
 145                150                155                160
Leu Val Leu Lys Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu 
                 165                170                175
Val Val Gln Met Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu 
             180                185                190
Cys Val Leu Asp Tyr Phe Ile Lys Leu Ser Pro Pro Ala Leu Leu Arg 
         195                200                205
Glu Pro Tyr Lys Thr Ala Ala Thr Pro Ile Asn Gly Ser Pro Arg Thr 
     210                215                220
Pro Arg Arg Gly Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu 
 225                230                235                240
Ser Asp Thr Arg Thr Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn 
                 245                250                255
Val Asp Glu Val Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Ile 
             260                265                270
Ser Ser Leu Gly Ile Val Ser Ser Asn Gly Leu Pro Glu Leu Glu Ser 
         275                280                285
Leu Ser Lys Arg Tyr Glu Glu Val Tyr Leu Lys Ser Lys Asp Leu Asp 
     290                295                300
Ala Arg Leu Phe Leu Asp His Asp Lys Thr Leu Gln Thr Asp Thr Ile 
 305                310                315                320
Asp Ser Phe Glu Thr Glu Arg Thr Pro Arg Lys Ser Asn Pro Asp Glu 
                 325                330                335
Glu Ala Asn Met Val Thr Pro His Thr Pro Val Arg Thr Val Met Asn 
             340                345                350
Thr Ile Gln Gln Leu Met Val Ile Leu Asn Ser Ala Ser Asp Gln Pro 
         355                360                365
Ser Glu Asn Leu Ile Ser Tyr Phe Ser Asn Cys Thr Val Asn Pro Lys 
     370                375                380
Glu Asn Ile Leu Lys Arg Val Lys Asp Val Gly His Ile Phe Lys Glu 
 385                390                395                400
Lys Phe Ala Ser Ala Val Gly Gln Gly Cys Ile Asp Ile Gly Ala Gln 
                 405                410                415
Arg Tyr Lys Leu Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met 
             420                425                430
Leu Lys Ser Glu Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu 
         435                440                445
Leu Asn Asp Asn Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu 
     450                455                460
Val Val Met Ala Thr Tyr Ser Arg Ser Met Leu Gln Asn Leu Asp Ser 
 465                470                475                480
Gly Thr Asp Leu Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys 
                 485                490                495
Ala Phe Asp Phe Tyr Lys Val Ile Glu Ser Phe Ile Lys Val Glu Ala 
             500                505                510
Asn Leu Thr Arg Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg 
         515                520                525
Ile Met Glu Ser Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu 
     530                535                540
Ile Lys Gln Ser Lys Asp Gly Glu Gly Pro Asp His Leu Glu Ser Ala 
 545                550                555                560
Cys Ser Leu Ser Leu Pro Leu Gln Ser Asn His Thr Ala Ala Asp Met 
                 565                570                575
Tyr Leu Ser Pro Ile Arg Ser Pro Lys Lys Arg Thr Ser Thr Thr Arg 
             580                585                590
Val Asn Ser Ala Ala Asn Thr Glu Thr Gln Ala Ala Ser Ala Phe His 
         595                600                605
Thr Gln Lys Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys 
     610                615                620
Val Tyr Arg Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Ala Arg Leu 
 625                630                635                640
Leu Ser Asp His Pro Glu Pro Glu His Ile Ile Trp Thr Leu Phe Gln 
                 645                650                655
His Thr Leu Glu Asn Glu Tyr Glu Leu Met Lys Asp Arg His Leu Asp 
             660                665                670
Gln Ile Met Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile 
         675                680                685
Asp Leu Lys Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His 
     690                695                700
Ala Ala Gln Glu Thr Phe Lys Arg Val Leu Ile Arg Glu Glu Glu Phe 
 705                710                715                720
Asp Ser Ile Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys 
                 725                730                735
Thr Asn Ile Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro 
             740                745                750
Ile Pro His Ile Pro Arg Ser Pro Tyr Lys Phe Ser Ser Ser Pro Leu 
         755                760                765
Arg Ile Pro Gly Gly Asn Ile Tyr Met Ser Pro Leu Lys Ser Pro Tyr 
     770                775                780
Lys Ile Ser Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser 
 785                790                795                800
Arg Ile Leu Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe 
                 805                810                815
Gln Lys Ile Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg 
             820                825                830
Ser Ala Glu Gly Gly Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe 
         835                840                845
Asp Ile Glu Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Ala 
     850                855                860
Glu Ser Lys Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr 
 865                870                875                880
Arg Met Gln Lys Gln Lys Leu Asn Asp Ser Met Glu Ile Ser Asn Lys 
                 885                890                895
Glu Glu Lys 
             900



<210> 1851
<211> 4839
<212> DNA
<213> Homo sapiens
<308> L41870
<400> 1851

tccggtttt  ctcagggga  gttgaaatt  tttttgtaa  gggagtcgg  agaggacgg  60
gcgtgcccc  cgtgcgcgc  cgtcgtcct  cccggcgct  ctccacagc  cgctggctc  120
cgccgcgga  aggcgtcat  ccgcccaaa  ccccccgaa  aacggccgc  accgccgcc  180
ctgccgccg  ggaaccccc  gcaccgccg  cgccgcccc  tcctgagga  gacccagag  240
aggacagcg  cccggagga  ctgcctctc  tcaggcttg  gtttgaaga  acagaagaa  300
ctgatttta  tgcattatg  cagaaatta  agataccag  tcatgtcag  gagagagct  360
ggttaactt  ggagaaagt  tcatctgtg  atggagtat  gggaggtta  attcaaaag  420
aaaaggaac  gtggggaat  tgtatcttt  ttgcagcag  tgacctaga  gagatgtcg  480
tcactttta  tgagctaca  aaaaacata  aaatcagtg  ccataaatt  tttaactta  540
taaaagaaa  tgataccag  accaaagtt  ataatgcta  gtcaagact  ttgaagaag  600
atgatgtat  gtttgcact  ttcagcaaa  tggaaagga  atgtgaact  atatatttg  660
cacaaccca  cagttcgat  tctactgaa  taaattctg  attggtgct  aaagtttct  720
ggatcacat  tttattagc  aaaggggaa  tattacaaa  ggaagatga  ctggtgatt  780
catttcagt  aatgctatg  gtccttgac  attttatta  actctcacc  cccatgttg  840
tcaaagaac  atataaaac  gctgttata  ccattaatg  ttcacctcg  acacccagg  900
gaggtcaga  caggagtgc  cggatagca  aacaactag  aaatgatac  agaattatt  960
aagttctct  taaagaaca  gaatgtaat  tagatgagg  gaaaaatgt  tatttcaaa  1020
attttatac  ttttatgaa  tctcttgga  ttgtaacat  taatggact  ccagaggtt  1080
aaaatcttt  taaacgata  gaagaaatt  atcttaaaa  taaagatct  gatgcaaga  1140
tatttttgg  tcatgataa  actcttcag  ctgattcta  agacagttt  gaaacacag  1200
gaacaccac  aaaaagtaa  cttgatgaa  aggtgaatg  aattcctcc  cacactcca  1260
ttaggactg  tatgaacac  atccaacaa  taatgatga  tttaaattc  gcaagtgat  1320
aaccttcag  aaatctgat  tcctatttt  acaactgca  agtgaatcc  aaagaaagt  1380
tactgaaaa  agtgaagga  ataggatac  tctttaaag  gaaatttgc  aaagctgtg  1440
gacagggtt  tgtcgaaat  ggatcacag  gatacaaac  tggagttcg  ttgtattac  1500
gagtaatgg  atccatgct  aaatcagaa  aagaacgat  atccattca  aattttagc  1560
aacttctga  tgacaacat  tttcatatg  ctttattgg  gtgcgctct  gaggttgta  1620
tggccacat  tagcagaag  acatctcag  atcttgatt  tggaacaga  ttgtctttc  1680
catggattc  gaatgtgct  aatttaaaa  cctttgatt  ttacaaagt  atcgaaagt  1740
ttatcaaag  agaaggcaa  ttgacaaga  aaatgataa  acatttaga  cgatgtgaa  1800
atcgaatca  ggaatccct  gcatggctc  cagattcac  tttatttga  cttattaaa  1860
aatcaaagg  ccgagaagg  ccaactgat  accttgaat  tgcttgtcc  cttaatctt  1920
ctctccaga  taatcacac  gcagcagat  tgtatcttt  tcctgtaag  tctccaaag  1980
aaaaaggtt  aactacgcg  gtaaattct  ctgcaaatg  agagacaca  gcaacctca  2040
ccttccaga  ccagaagcc  ttgaaatct  cctctcttt  actgtttta  aaaaaagtg  2100
atcggctag  ctatctccg  ctaaataca  tttgtgaac  ccttctgtc  gagcaccca  2160
aattagaac  tatcatctg  acccttttc  agcacaccc  gcagaatga  tatgaactc  2220
tgagagaca  gcatttgga  caaattatg  tgtgttcca  gtatggcat  tgcaaagtg  2280
agaatatag  ccttaaatt  aaaatcatt  taacagcat  caaggatct  cctcatgct  2340
ttcaggaga  attcaaacg  gttttgatc  aagaagagg  gtatgattc  attatagta  2400
tctataact  ggtcttcat  cagagactg  aaacaaata  tttgcagta  gcttccacc  2460
ggcccccta  cttgtcacc  atacctcac  ttcctcgaa  cccttacaa  tttcctagt  2520
cacccttac  gattcctgg  gggaacatc  atatttcac  cctgaagag  ccatataaa  2580
tttcagaag  tctgccaac  ccaacaaaa  tgactccaa  atcaagaat  ttagtatca  2640
ttggtgaat  attcgggac  tctgagaag  tccagaaaa  aaatcagat  gtatgtaac  2700
gcgaccgtg  gctcaaaag  agtgctgaa  gaagcaacc  tcctaaacc  ctgaaaaaa  2760
tacgctttg  tattgaagg  tcagatgaa  cagatggaa  taaacatct  ccaggagag  2820
ccaaatttc  gcagaaact  gcagaaatg  cttctactc  aacacgaat  caaaagcag  2880
aaatgaatg  tagcatgga  acctcaaac  aggaagaga  atgaggatc  caggacctt  2940
gtggacact  tgtacacct  tggattcat  gtctctcac  gatgtgact  tataacttt  3000
ccaggttct  tttatggcc  catttaata  cttcagctc  ttttgtgga  ataaaatgt  3060
cagatgcaa  tgtttgggt  attcctaag  cacttgaaa  gttagtcat  gttatttat  3120
caagattga  aatcttgtg  aaatcctgc  atttaaaaa  ttgtagcag  ttgtttcct  3180
ttccaaagt  aaattgctg  gctttatgg  tagtaagaa  ggccctaga  tgggagtcc  3240
gataaccca  gcctgtctg  ctactttgc  ttcttttgt  gcatatagg  gatgtttgc  3300
cttgttttt  ttaatttat  tgtatattt  tttaattta  catgaacac  cttagaaaa  3360
gtgtcctat  tatcttcca  atgcaattt  attgactgc  cattcacca  aattatcct  3420
aactcttct  caaaaatgg  tattattag  aattagaaa  aaattacta  ttttacaca  3480
tagatttta  tttactatt  gaatctgat  tactgtgtg  ttgttttat  aaattttgc  3540
tttaattaa  taaaagctg  aagcaaagt  taaccatat  atactatca  actactgaa  3600
cagatttca  acctcagaa  gtaaaagaa  ttactgatt  ttttcttca  ccaacttat  3660
tttttaaat  aggattatt  atagtactc  tggttttta  accattcag  tcactgaat  3720
tataaagta  ccatctagt  cttgaaaaa  taaagtgtt  tgccagatc  taggtatag  3780
ggaccctaa  acagtatat  ccaagtgca  tttctaatg  ttctgggtc  tgaagaatt  3840
agatacaaa  taattttac  ccataaaca  actgttaat  ataggagcc  taatttttt  3900
ttcatagag  tttgtctaa  tgcatctca  aattattct  ccctcctta  tttgggaag  3960
tttgtgttt  ctctggaat  gtacatgtc  tccatgtat  ttttgaact  gcaattgtc  4020
atttatctt  tattttttt  agtcagtat  gtctaacac  ggcatgttc  aagccacat  4080
atttctagt  caaaattac  agtaatcaa  ggtcattat  ggttaggca  taatgtttc  4140
atctgattt  gtgcaaaag  ttcaaatta  aacagctgc  ttagaaaaa  aggcgcttc  4200
cccctcccc  acacctaaa  gtgtattta  actatcttg  gtgattaac  tatttagag  4260
tgctgtaac  taaaatagg  gatatttaa  gtagcttca  ctagctttt  ggaaaatca  4320
tttgtctaa  tcagaatta  ttttaaaaa  aaatctggt  ttgttagaa  acaaaattt  4380
attttgtgc  catttaagt  tcaaactta  tattttgac  gttattttg  taacaatga  4440
actagaaaa  ttgactcca  ttcatcatt  tttctgcat  aatatcata  aaatcagtt  4500
gtttttagg  caagggctt  ctatttctg  gtcttttgc  actaagttc  cattagaat  4560
agtgccaga  ttttaggaa  ttcagagat  gtgtattga  atttcttaa  taatgcttc  4620
gatattatt  ctttattgc  tttttgtat  ggttaaaac  gtacattta  aattgctat  4680
ttactattt  ctacaatta  tagtttgtc  attttaaaa  aaattagtt  ttaagagtc  4740
taatggtct  atgttgtgt  ctttgtatt  agtacacta  tgttctctt  tctgtctag  4800
agaagatag  tagaagata  ctctcctag  atctcatcc  4839



<210> 1852
<211> 928
<212> PRT
<213> Homo sapiens
<308> P06400
<400> 1852

Met Pro Pro Lys Thr Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala 
  1               5                  10                  15
Ala Ala Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp 
             20                  25                  30
Pro Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu 
         35                  40                  45
Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu 
     50                  55                  60
Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys 
 65                  70                  75                  80
Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys Lys Lys 
                 85                  90                  95
Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val Asp Leu Asp Glu 
             100                105                110
Met Ser Phe Thr Phe Thr Glu Leu Gln Lys Asn Ile Glu Ile Ser Val 
         115                120                125
His Lys Phe Phe Asn Leu Leu Lys Glu Ile Asp Thr Ser Thr Lys Val 
     130                135                140
Asp Asn Ala Met Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala 
 145                150                155                160
Leu Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln 
                 165                170                175
Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys 
             180                185                190
Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met 
         195                200                205
Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val Leu Asp 
     210                215                220
Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys Glu Pro Tyr Lys 
 225                230                235                240
Thr Ala Val Ile Pro Ile Asn Gly Ser Pro Arg Thr Pro Arg Arg Gly 
                 245                250                255
Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg 
             260                265                270
Ile Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val 
         275                280                285
Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly 
     290                295                300
Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg 
 305                310                315                320
Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe 
                 325                330                335
Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp Ser Phe Glu 
             340                345                350
Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp Glu Glu Val Asn Val 
         355                360                365
Ile Pro Pro His Thr Pro Val Arg Thr Val Met Asn Thr Ile Gln Gln 
     370                375                380
Leu Met Met Ile Leu Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu 
 385                390                395                400
Ile Ser Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu 
                 405                410                415
Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys 
             420                425                430
Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu 
         435                440                445
Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser Glu 
     450                455                460
Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn 
 465                470                475                480
Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu Val Val Met Ala 
                 485                490                495
Thr Tyr Ser Arg Ser Thr Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu 
             500                505                510
Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe 
         515                520                525
Tyr Lys Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg 
     530                535                540
Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser 
 545                550                555                560
Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser 
                 565                570                575
Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys Pro Leu 
             580                585                590
Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp Met Tyr Leu Ser 
         595                600                605
Pro Val Arg Ser Pro Lys Lys Lys Gly Ser Thr Thr Arg Val Asn Ser 
     610                615                620
Thr Ala Asn Ala Glu Thr Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys 
 625                630                635                640
Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg 
                 645                650                655
Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu 
             660                665                670
His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu 
         675                680                685
Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met 
     690                695                700
Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp Leu Lys 
 705                710                715                720
Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His Ala Val Gln 
                 725                730                735
Glu Thr Phe Lys Arg Val Leu Ile Lys Glu Glu Glu Tyr Asp Ser Ile 
             740                745                750
Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile 
         755                760                765
Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His 
     770                775                780
Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro 
 785                790                795                800
Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile Ser 
                 805                810                815
Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser Arg Ile Leu 
             820                825                830
Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys Ile 
         835                840                845
Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala Glu 
     850                855                860
Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe Asp Ile Glu 
 865                870                875                880
Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys 
                 885                890                895
Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln 
             900                905                910
Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys 
         915                920                925



<210> 1853
<211> 4432
<212> DNA
<213> Rattus norvegicus
<308> D25233
<400> 1853

ccggaggac  accccgcgc  ggacagtga  cccgaagag  tgcccctga  caggcttga  60
tttgaaaaa  ttgaagaac  tgaatttat  gcattatgt  agaagttaa  ggtgcccga  120
catgtcaga  agagagctt  gctaacgtg  gagaaagtt  catctgtgg  tggaatcct  180
gaaggatat  ttcagaaga  gaaggaact  tggggcatc  gcatcttca  tgcagcagt  240
gacctggat  agatgccat  cacttttac  gagcttcag  aaagcatag  aaccagtgt  300
tataaattc  ttgacttat  aaaagaaat  gataccagt  ccaaagttg  taatgctgt  360
tcaaggcta  tgaagaagt  caatgtgtt  tgtgcactc  acagcaaat  agaacggac  420
tgtggactt  tatatttga  acagcccag  agtgggtta  ctactgaaa  aaattctat  480
ttggtgcta  aagtttctt  gatcacctt  ttactagct  aaggagaag  agtacagat  540
gaagatgat  tggtgatct  atttcagtt  atgttgtgt  tacttgact  ttttatcaa  600
ctctcgcct  ctgcgctgc  cagagagcc  tacaaaaca  ctgcaacac  cattaatgg  660
tcacctcgg  cacccagaa  aggtcagaa  aggagtgct  ggatagcaa  acaactaga  720
agtgataca  gaactattg  agttctctg  aaggagcac  agtgtaatg  agatgaggt  780
aaaaatgtt  atttcaaaa  ttttatccc  tttataagt  cacttggaa  tgtatcatc  840
aatggactt  cagagcttg  aagtctttc  aaacgctac  aagaagttt  tcttaaaag  900
aaagattta  atgcaagac  atttttgga  catgacaaa  cacttcaga  tgatactat  960
gacagtttt  aaacagaga  aactccacg  aaaagcaac  ctgatgaag  ggcaaacat  1020
gttactcca  acactccag  taggactgt  atgaatact  ttcaacagt  aatggtgat  1080
ttaaattct  caagtgatc  gccatcaga  aatctgatt  cctacttca  taattgcac  1140
gtgaatcca  aagaaaata  cctaaaaag  gtaaaggat  ttggacaca  ctttaaaga  1200
aagtttgct  gcgctgtgg  gcagggatg  attgacatt  gagcacagc  atataaact  1260
ggggttcga  tgtattatc  tgtgatgga  tcgatgctt  aatcagaag  agaacgttt  1320
tccattcag  attttagca  actcctaaa  gacaacatc  ttcatatgt  tttattggc  1380
tgtgctctt  aagttgtaa  ggctacata  agcaggagt  tgttacaga  tcttgattc  1440
ggaacagat  tgtccttcc  gtggattct  aatgtactt  atttaaaag  ctttgattt  1500
tacaaagtg  ttgaaagtt  tatcaaagt  gaagccaac  tgacaagag  aatgataaa  1560
catttagaa  gatgtgagc  tcgaatcat  gaatccctt  catggcttt  tgattcacc  1620
ttgtttgat  tcataaagc  gtccaagga  ggggaagga  ctgatcacc  tgagtctgc  1680
tgttctctc  gcctccctc  ccagagtaa  cacactgca  cagatatgt  tctttctcc  1740
ataagatct  caaagaaaa  aacttctac  acacgtgta  attctgcgg  aaatacaga  1800
acgcaagca  cctcagcct  ccatactca  aagccattg  aatctacct  cctttccct  1860
ttttacaaa  aagtgtacc  tctagcata  ctccgacta  atacactgt  tgcgcgcct  1920
ctgtctgac  acccagagc  agaacacat  atctggact  tgtttcagc  tacattgga  1980
aatgagtat  agctcatga  agaccgaca  ttggaccag  ttatgatgt  ttctatgta  2040
ggcatctgc  aggtgaaaa  cattgacct  aaattcaaa  tcatcgtaa  tgcgtataa  2100
gatcttcct  acgctgccc  ggagacctt  aaacgtgtt  tgatcagag  agaggagtt  2160
gattccatt  tagtgttct  caactcagt  ttcatgcag  gactaaaaa  aaatatttt  2220
cagtatgcc  ccaccaggc  tcctacctt  tcaccaata  ctcacattc  tcgaagccc  2280
tacaagttc  cgagttcac  cttgcggat  cctggaggt  acatctata  gtcacccct  2340
aagagtcct  ataaaattt  agaaggtct  ccaacaccc  caaaaatga  tccaagatc  2400
agaatcttg  tctcaatcg  tgaatcatt  gggacatcc  agaagttcc  gaaaataaa  2460
cagatggtg  gtaacagtg  cagagtgct  aaaagaagt  ctgaaggcg  caatccccc  2520
aaacccctg  agaagctgc  ctttgacat  gaaggatcc  atgaagcag  cgggagtaa  2580
catctccca  cggagtcca  attccaaca  aaactggca  aaatgactt  tactcgaac  2640
cgaatgcaa  agcagaaac  gaatgatag  atggaaatc  caaacaagg  ggaaaagtg  2700
tgatctcag  accctaaca  tgtagaccc  cgggacacc  gactcgtgt  tcatggatg  2760
gactatagt  cccaggttc  gctcatgtt  tagatataa  atgtgcagg  acagctgaa  2820
atttatgtg  gtgatttgt  agccacttc  atgttgtaa  caatggtat  gaattgaca  2880
tacacagga  tgagaatct  gtgcagatc  tgccattta  aatatgaaa  cagattgtt  2940
gcatttcca  caggagcct  ctgccctca  aagtgaggc  gcctctgga  ggagtccta  3000
caactccct  acatctggc  gactacttt  cctttcctt  tggcacatg  gtgatgttt  3060
ctcttggtt  tattaattt  tatgtattt  ttaatttaa  gtgaatatc  ttagaaaat  3120
tgtcttgtc  tccaaatgc  agttgattg  ttgtccaca  tcaaccaaa  tatcttgaa  3180
cctctactg  aacagattg  tacaaactg  ggaaaagta  taatttgta  acattggac  3240
tgttttaat  ctagaatct  atgtgccat  tgtttgttt  acacatttt  cctttgaaa  3300
agaagtaaa  aaagtataa  catatgata  tgtcttact  ctgacacag  tttcatacc  3360
cagaccctc  aagaaccaa  tcttttatt  atccaactc  tactttaaa  tgaagacta  3420
tgataatac  ccaggtttg  tttttcttt  aatctttca  atcactgaa  ctttaagta  3480
ccatgtagt  cttgaaaat  aagtctggc  acaactgta  ttcagagga  cctagtaca  3540
tacaaccca  gtgcacttt  taatgtctc  gggtcctga  gaatcaaga  acaaattaa  3600
tatgttctg  aagcagacc  ttaactata  gagccttcg  tttaactat  ttctgtaag  3660
agaccgtta  ctataggag  cttcggttt  ccctcatac  agtgtctaa  cacatctca  3720
cagttcact  tgctcttct  catccaggg  tgatgtgtt  cctctggaa  ggtacatgt  3780
ttccagggt  ttttgaact  gcaggtatc  attttttta  gccaatctg  tctaataac  3840
ctggcttct  caaagccac  gcatttcta  tccagctgt  ccgaagctt  agactaaaa  3900
agctgcatt  aaagaagag  cactccctt  acccccccc  cccacctaa  ggtgtttac  3960
ttatcttgt  ggattaact  atttagaga  gctataatt  aaaataggc  gtatttaag  4020
tagcgtcag  tagcattta  gaaaatcat  ttttctaaa  tccatactt  ttgaaaaga  4080
atctggtct  gttagaaaa  aaatttcta  tttgtcctc  atttagttt  agttttact  4140
ggttgatag  tatctcgat  acaaaggcc  tagacagct  cccccattt  ttcattgag  4200
tttgcatgg  catcacaca  gttagttgg  tttaggtca  gggctgacc  tacttctag  4260
tcttttgct  gtaagttca  gttagaatt  gtgacagaa  cataggaat  ttcagagat  4320
ctctattaa  atttcttaa  actgcagac  ctgcttttg  ttttgtact  gttaaaact  4380
tacattcag  ttgctatgt  cctattttc  ataatagtt  gtctatttt  ca  4432



<210> 1854
<211> 899
<212> PRT
<213> Rattus norvegicus
<308> P33568
<400> 1854

Pro Glu Asp Asp Pro Ala Gln Asp Ser Asp Pro Glu Glu Leu Pro Leu 
  1               5                  10                  15
Ile Arg Leu Glu Phe Glu Lys Ile Glu Glu Pro Glu Phe Ile Ala Leu 
             20                  25                  30
Cys Gln Lys Leu Lys Val Pro Asp His Val Arg Glu Arg Ala Trp Leu 
         35                  40                  45
Thr Trp Glu Lys Val Ser Ser Val Asp Gly Ile Leu Glu Gly Tyr Ile 
     50                  55                  60
Gln Lys Lys Lys Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val 
 65                  70                  75                  80
Asp Leu Asp Glu Met Pro Phe Thr Phe Thr Glu Leu Gln Lys Ser Ile 
                 85                  90                  95
Glu Thr Ser Val Tyr Lys Phe Phe Asp Leu Leu Lys Glu Ile Asp Thr 
             100                105                110
Ser Thr Lys Val Asp Asn Ala Val Ser Arg Leu Leu Lys Lys Tyr Asn 
         115                120                125
Val Leu Cys Ala Leu Tyr Ser Lys Leu Glu Arg Thr Cys Gly Leu Ile 
     130                135                140
Tyr Leu Thr Gln Pro Ser Ser Gly Leu Ser Thr Glu Ile Asn Ser Met 
 145                150                155                160
Leu Val Leu Lys Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu 
                 165                170                175
Val Val Gln Met Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu 
             180                185                190
Cys Val Leu Asp Tyr Phe Ile Lys Leu Ser Pro Pro Ala Leu Leu Arg 
         195                200                205
Glu Pro Tyr Lys Thr Ala Ala Thr Pro Ile Asn Gly Ser Pro Arg Thr 
     210                215                220
Pro Arg Arg Gly Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu 
 225                230                235                240
Ser Asp Thr Arg Thr Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn 
                 245                250                255
Val Asp Glu Val Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Ile 
             260                265                270
Ser Ser Leu Gly Ile Val Ser Ser Asn Gly Leu Pro Glu Leu Glu Ser 
         275                280                285
Leu Ser Lys Arg Tyr Glu Glu Val Tyr Leu Lys Ser Lys Asp Leu Asp 
     290                295                300
Ala Arg Leu Phe Leu Asp His Asp Lys Thr Leu Gln Thr Asp Thr Ile 
 305                310                315                320
Asp Ser Phe Glu Thr Glu Arg Thr Pro Arg Lys Ser Asn Pro Asp Glu 
                 325                330                335
Glu Ala Asn Met Val Thr Pro His Thr Pro Val Arg Thr Val Met Asn 
             340                345                350
Thr Ile Gln Gln Leu Met Val Ile Leu Asn Ser Ala Ser Asp Gln Pro 
         355                360                365
Ser Glu Asn Leu Ile Ser Tyr Phe Ser Asn Cys Thr Val Asn Pro Lys 
     370                375                380
Glu Asn Ile Leu Lys Arg Val Lys Asp Val Gly His Ile Phe Lys Glu 
 385                390                395                400
Lys Phe Ala Ser Ala Val Gly Gln Gly Cys Ile Asp Ile Gly Ala Gln 
                 405                410                415
Arg Tyr Lys Leu Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met 
             420                425                430
Leu Lys Ser Glu Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu 
         435                440                445
Leu Asn Asp Asn Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu 
     450                455                460
Val Val Met Ala Thr Tyr Ser Arg Ser Met Leu Gln Asn Leu Asp Ser 
 465                470                475                480
Gly Thr Asp Leu Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys 
                 485                490                495
Ala Phe Asp Phe Tyr Lys Val Ile Glu Ser Phe Ile Lys Val Glu Ala 
             500                505                510
Asn Leu Thr Arg Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg 
         515                520                525
Ile Met Glu Ser Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu 
     530                535                540
Ile Lys Gln Ser Lys Asp Gly Glu Gly Pro Asp His Leu Glu Ser Ala 
 545                550                555                560
Cys Ser Leu Ser Leu Pro Leu Gln Ser Asn His Thr Ala Ala Asp Met 
                 565                570                575
Tyr Leu Ser Pro Ile Arg Ser Pro Lys Lys Arg Thr Ser Thr Thr Arg 
             580                585                590
Val Asn Ser Ala Ala Asn Thr Glu Thr Gln Ala Ala Ser Ala Phe His 
         595                600                605
Thr Gln Lys Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys 
     610                615                620
Val Tyr Arg Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Ala Arg Leu 
 625                630                635                640
Leu Ser Asp His Pro Glu Pro Glu His Ile Ile Trp Thr Leu Phe Gln 
                 645                650                655
His Thr Leu Glu Asn Glu Tyr Glu Leu Met Lys Asp Arg His Leu Asp 
             660                665                670
Gln Ile Met Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile 
         675                680                685
Asp Leu Lys Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His 
     690                695                700
Ala Ala Gln Glu Thr Phe Lys Arg Val Leu Ile Arg Glu Glu Glu Phe 
 705                710                715                720
Asp Ser Ile Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys 
                 725                730                735
Thr Asn Ile Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro 
             740                745                750
Ile Pro His Ile Pro Arg Ser Pro Tyr Lys Phe Ser Ser Ser Pro Leu 
         755                760                765
Arg Ile Pro Gly Gly Asn Ile Tyr Met Ser Pro Leu Lys Ser Pro Tyr 
     770                775                780
Lys Ile Ser Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser 
 785                790                795                800
Arg Ile Leu Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe 
                 805                810                815
Gln Lys Ile Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg 
             820                825                830
Ser Ala Glu Gly Gly Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe 
         835                840                845
Asp Ile Glu Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Ala 
     850                855                860
Glu Ser Lys Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr 
 865                870                875                880
Arg Met Gln Lys Gln Lys Leu Asn Asp Ser Met Glu Ile Ser Asn Lys 
                 885                890                895
Glu Glu Lys 
             900



<210> 1855
<211> 4839
<212> DNA
<213> Homo sapiens
<308> L41870
<400> 1855

tccggtttt  ctcagggga  gttgaaatt  tttttgtaa  gggagtcgg  agaggacgg  60
gcgtgcccc  cgtgcgcgc  cgtcgtcct  cccggcgct  ctccacagc  cgctggctc  120
cgccgcgga  aggcgtcat  ccgcccaaa  ccccccgaa  aacggccgc  accgccgcc  180
ctgccgccg  ggaaccccc  gcaccgccg  cgccgcccc  tcctgagga  gacccagag  240
aggacagcg  cccggagga  ctgcctctc  tcaggcttg  gtttgaaga  acagaagaa  300
ctgatttta  tgcattatg  cagaaatta  agataccag  tcatgtcag  gagagagct  360
ggttaactt  ggagaaagt  tcatctgtg  atggagtat  gggaggtta  attcaaaag  420
aaaaggaac  gtggggaat  tgtatcttt  ttgcagcag  tgacctaga  gagatgtcg  480
tcactttta  tgagctaca  aaaaacata  aaatcagtg  ccataaatt  tttaactta  540
taaaagaaa  tgataccag  accaaagtt  ataatgcta  gtcaagact  ttgaagaag  600
atgatgtat  gtttgcact  ttcagcaaa  tggaaagga  atgtgaact  atatatttg  660
cacaaccca  cagttcgat  tctactgaa  taaattctg  attggtgct  aaagtttct  720
ggatcacat  tttattagc  aaaggggaa  tattacaaa  ggaagatga  ctggtgatt  780
catttcagt  aatgctatg  gtccttgac  attttatta  actctcacc  cccatgttg  840
tcaaagaac  atataaaac  gctgttata  ccattaatg  ttcacctcg  acacccagg  900
gaggtcaga  caggagtgc  cggatagca  aacaactag  aaatgatac  agaattatt  960
aagttctct  taaagaaca  gaatgtaat  tagatgagg  gaaaaatgt  tatttcaaa  1020
attttatac  ttttatgaa  tctcttgga  ttgtaacat  taatggact  ccagaggtt  1080
aaaatcttt  taaacgata  gaagaaatt  atcttaaaa  taaagatct  gatgcaaga  1140
tatttttgg  tcatgataa  actcttcag  ctgattcta  agacagttt  gaaacacag  1200
gaacaccac  aaaaagtaa  cttgatgaa  aggtgaatg  aattcctcc  cacactcca  1260
ttaggactg  tatgaacac  atccaacaa  taatgatga  tttaaattc  gcaagtgat  1320
aaccttcag  aaatctgat  tcctatttt  acaactgca  agtgaatcc  aaagaaagt  1380
tactgaaaa  agtgaagga  ataggatac  tctttaaag  gaaatttgc  aaagctgtg  1440
gacagggtt  tgtcgaaat  ggatcacag  gatacaaac  tggagttcg  ttgtattac  1500
gagtaatgg  atccatgct  aaatcagaa  aagaacgat  atccattca  aattttagc  1560
aacttctga  tgacaacat  tttcatatg  ctttattgg  gtgcgctct  gaggttgta  1620
tggccacat  tagcagaag  acatctcag  atcttgatt  tggaacaga  ttgtctttc  1680
catggattc  gaatgtgct  aatttaaaa  cctttgatt  ttacaaagt  atcgaaagt  1740
ttatcaaag  agaaggcaa  ttgacaaga  aaatgataa  acatttaga  cgatgtgaa  1800
atcgaatca  ggaatccct  gcatggctc  cagattcac  tttatttga  cttattaaa  1860
aatcaaagg  ccgagaagg  ccaactgat  accttgaat  tgcttgtcc  cttaatctt  1920
ctctccaga  taatcacac  gcagcagat  tgtatcttt  tcctgtaag  tctccaaag  1980
aaaaaggtt  aactacgcg  gtaaattct  ctgcaaatg  agagacaca  gcaacctca  2040
ccttccaga  ccagaagcc  ttgaaatct  cctctcttt  actgtttta  aaaaaagtg  2100
atcggctag  ctatctccg  ctaaataca  tttgtgaac  ccttctgtc  gagcaccca  2160
aattagaac  tatcatctg  acccttttc  agcacaccc  gcagaatga  tatgaactc  2220
tgagagaca  gcatttgga  caaattatg  tgtgttcca  gtatggcat  tgcaaagtg  2280
agaatatag  ccttaaatt  aaaatcatt  taacagcat  caaggatct  cctcatgct  2340
ttcaggaga  attcaaacg  gttttgatc  aagaagagg  gtatgattc  attatagta  2400
tctataact  ggtcttcat  cagagactg  aaacaaata  tttgcagta  gcttccacc  2460
ggcccccta  cttgtcacc  atacctcac  ttcctcgaa  cccttacaa  tttcctagt  2520
cacccttac  gattcctgg  gggaacatc  atatttcac  cctgaagag  ccatataaa  2580
tttcagaag  tctgccaac  ccaacaaaa  tgactccaa  atcaagaat  ttagtatca  2640
ttggtgaat  attcgggac  tctgagaag  tccagaaaa  aaatcagat  gtatgtaac  2700
gcgaccgtg  gctcaaaag  agtgctgaa  gaagcaacc  tcctaaacc  ctgaaaaaa  2760
tacgctttg  tattgaagg  tcagatgaa  cagatggaa  taaacatct  ccaggagag  2820
ccaaatttc  gcagaaact  gcagaaatg  cttctactc  aacacgaat  caaaagcag  2880
aaatgaatg  tagcatgga  acctcaaac  aggaagaga  atgaggatc  caggacctt  2940
gtggacact  tgtacacct  tggattcat  gtctctcac  gatgtgact  tataacttt  3000
ccaggttct  tttatggcc  catttaata  cttcagctc  ttttgtgga  ataaaatgt  3060
cagatgcaa  tgtttgggt  attcctaag  cacttgaaa  gttagtcat  gttatttat  3120
caagattga  aatcttgtg  aaatcctgc  atttaaaaa  ttgtagcag  ttgtttcct  3180
ttccaaagt  aaattgctg  gctttatgg  tagtaagaa  ggccctaga  tgggagtcc  3240
gataaccca  gcctgtctg  ctactttgc  ttcttttgt  gcatatagg  gatgtttgc  3300
cttgttttt  ttaatttat  tgtatattt  tttaattta  catgaacac  cttagaaaa  3360
gtgtcctat  tatcttcca  atgcaattt  attgactgc  cattcacca  aattatcct  3420
aactcttct  caaaaatgg  tattattag  aattagaaa  aaattacta  ttttacaca  3480
tagatttta  tttactatt  gaatctgat  tactgtgtg  ttgttttat  aaattttgc  3540
tttaattaa  taaaagctg  aagcaaagt  taaccatat  atactatca  actactgaa  3600
cagatttca  acctcagaa  gtaaaagaa  ttactgatt  ttttcttca  ccaacttat  3660
tttttaaat  aggattatt  atagtactc  tggttttta  accattcag  tcactgaat  3720
tataaagta  ccatctagt  cttgaaaaa  taaagtgtt  tgccagatc  taggtatag  3780
ggaccctaa  acagtatat  ccaagtgca  tttctaatg  ttctgggtc  tgaagaatt  3840
agatacaaa  taattttac  ccataaaca  actgttaat  ataggagcc  taatttttt  3900
ttcatagag  tttgtctaa  tgcatctca  aattattct  ccctcctta  tttgggaag  3960
tttgtgttt  ctctggaat  gtacatgtc  tccatgtat  ttttgaact  gcaattgtc  4020
atttatctt  tattttttt  agtcagtat  gtctaacac  ggcatgttc  aagccacat  4080
atttctagt  caaaattac  agtaatcaa  ggtcattat  ggttaggca  taatgtttc  4140
atctgattt  gtgcaaaag  ttcaaatta  aacagctgc  ttagaaaaa  aggcgcttc  4200
cccctcccc  acacctaaa  gtgtattta  actatcttg  gtgattaac  tatttagag  4260
tgctgtaac  taaaatagg  gatatttaa  gtagcttca  ctagctttt  ggaaaatca  4320
tttgtctaa  tcagaatta  ttttaaaaa  aaatctggt  ttgttagaa  acaaaattt  4380
attttgtgc  catttaagt  tcaaactta  tattttgac  gttattttg  taacaatga  4440
actagaaaa  ttgactcca  ttcatcatt  tttctgcat  aatatcata  aaatcagtt  4500
gtttttagg  caagggctt  ctatttctg  gtcttttgc  actaagttc  cattagaat  4560
agtgccaga  ttttaggaa  ttcagagat  gtgtattga  atttcttaa  taatgcttc  4620
gatattatt  ctttattgc  tttttgtat  ggttaaaac  gtacattta  aattgctat  4680
ttactattt  ctacaatta  tagtttgtc  attttaaaa  aaattagtt  ttaagagtc  4740
taatggtct  atgttgtgt  ctttgtatt  agtacacta  tgttctctt  tctgtctag  4800
agaagatag  tagaagata  ctctcctag  atctcatcc  4839



<210> 1856
<211> 928
<212> PRT
<213> Homo sapiens
<308> P06400
<400> 1856

Met Pro Pro Lys Thr Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala 
  1               5                  10                  15
Ala Ala Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp 
             20                  25                  30
Pro Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu 
         35                  40                  45
Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu 
     50                  55                  60
Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys 
 65                  70                  75                  80
Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys Lys Lys 
                 85                  90                  95
Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val Asp Leu Asp Glu 
             100                105                110
Met Ser Phe Thr Phe Thr Glu Leu Gln Lys Asn Ile Glu Ile Ser Val 
         115                120                125
His Lys Phe Phe Asn Leu Leu Lys Glu Ile Asp Thr Ser Thr Lys Val 
     130                135                140
Asp Asn Ala Met Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala 
 145                150                155                160
Leu Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln 
                 165                170                175
Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys 
             180                185                190
Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met 
         195                200                205
Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val Leu Asp 
     210                215                220
Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys Glu Pro Tyr Lys 
 225                230                235                240
Thr Ala Val Ile Pro Ile Asn Gly Ser Pro Arg Thr Pro Arg Arg Gly 
                 245                250                255
Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg 
             260                265                270
Ile Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val 
         275                280                285
Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly 
     290                295                300
Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg 
 305                310                315                320
Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe 
                 325                330                335
Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp Ser Phe Glu 
             340                345                350
Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp Glu Glu Val Asn Val 
         355                360                365
Ile Pro Pro His Thr Pro Val Arg Thr Val Met Asn Thr Ile Gln Gln 
     370                375                380
Leu Met Met Ile Leu Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu 
 385                390                395                400
Ile Ser Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu 
                 405                410                415
Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys 
             420                425                430
Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu 
         435                440                445
Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser Glu 
     450                455                460
Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn 
 465                470                475                480
Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu Val Val Met Ala 
                 485                490                495
Thr Tyr Ser Arg Ser Thr Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu 
             500                505                510
Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe 
         515                520                525
Tyr Lys Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg 
     530                535                540
Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser 
 545                550                555                560
Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser 
                 565                570                575
Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys Pro Leu 
             580                585                590
Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp Met Tyr Leu Ser 
         595                600                605
Pro Val Arg Ser Pro Lys Lys Lys Gly Ser Thr Thr Arg Val Asn Ser 
     610                615                620
Thr Ala Asn Ala Glu Thr Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys 
 625                630                635                640
Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg 
                 645                650                655
Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu 
             660                665                670
His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu 
         675                680                685
Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met 
     690                695                700
Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp Leu Lys 
 705                710                715                720
Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His Ala Val Gln 
                 725                730                735
Glu Thr Phe Lys Arg Val Leu Ile Lys Glu Glu Glu Tyr Asp Ser Ile 
             740                745                750
Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile 
         755                760                765
Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His 
     770                775                780
Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro 
 785                790                795                800
Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile Ser 
                 805                810                815
Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser Arg Ile Leu 
             820                825                830
Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys Ile 
         835                840                845
Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala Glu 
     850                855                860
Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe Asp Ile Glu 
 865                870                875                880
Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys 
                 885                890                895
Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln 
             900                905                910
Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys 
         915                920                925



<210> 1857
<211> 4432
<212> DNA
<213> Rattus norvegicus
<308> D25233
<400> 1857

ccggaggac  accccgcgc  ggacagtga  cccgaagag  tgcccctga  caggcttga  60
tttgaaaaa  ttgaagaac  tgaatttat  gcattatgt  agaagttaa  ggtgcccga  120
catgtcaga  agagagctt  gctaacgtg  gagaaagtt  catctgtgg  tggaatcct  180
gaaggatat  ttcagaaga  gaaggaact  tggggcatc  gcatcttca  tgcagcagt  240
gacctggat  agatgccat  cacttttac  gagcttcag  aaagcatag  aaccagtgt  300
tataaattc  ttgacttat  aaaagaaat  gataccagt  ccaaagttg  taatgctgt  360
tcaaggcta  tgaagaagt  caatgtgtt  tgtgcactc  acagcaaat  agaacggac  420
tgtggactt  tatatttga  acagcccag  agtgggtta  ctactgaaa  aaattctat  480
ttggtgcta  aagtttctt  gatcacctt  ttactagct  aaggagaag  agtacagat  540
gaagatgat  tggtgatct  atttcagtt  atgttgtgt  tacttgact  ttttatcaa  600
ctctcgcct  ctgcgctgc  cagagagcc  tacaaaaca  ctgcaacac  cattaatgg  660
tcacctcgg  cacccagaa  aggtcagaa  aggagtgct  ggatagcaa  acaactaga  720
agtgataca  gaactattg  agttctctg  aaggagcac  agtgtaatg  agatgaggt  780
aaaaatgtt  atttcaaaa  ttttatccc  tttataagt  cacttggaa  tgtatcatc  840
aatggactt  cagagcttg  aagtctttc  aaacgctac  aagaagttt  tcttaaaag  900
aaagattta  atgcaagac  atttttgga  catgacaaa  cacttcaga  tgatactat  960
gacagtttt  aaacagaga  aactccacg  aaaagcaac  ctgatgaag  ggcaaacat  1020
gttactcca  acactccag  taggactgt  atgaatact  ttcaacagt  aatggtgat  1080
ttaaattct  caagtgatc  gccatcaga  aatctgatt  cctacttca  taattgcac  1140
gtgaatcca  aagaaaata  cctaaaaag  gtaaaggat  ttggacaca  ctttaaaga  1200
aagtttgct  gcgctgtgg  gcagggatg  attgacatt  gagcacagc  atataaact  1260
ggggttcga  tgtattatc  tgtgatgga  tcgatgctt  aatcagaag  agaacgttt  1320
tccattcag  attttagca  actcctaaa  gacaacatc  ttcatatgt  tttattggc  1380
tgtgctctt  aagttgtaa  ggctacata  agcaggagt  tgttacaga  tcttgattc  1440
ggaacagat  tgtccttcc  gtggattct  aatgtactt  atttaaaag  ctttgattt  1500
tacaaagtg  ttgaaagtt  tatcaaagt  gaagccaac  tgacaagag  aatgataaa  1560
catttagaa  gatgtgagc  tcgaatcat  gaatccctt  catggcttt  tgattcacc  1620
ttgtttgat  tcataaagc  gtccaagga  ggggaagga  ctgatcacc  tgagtctgc  1680
tgttctctc  gcctccctc  ccagagtaa  cacactgca  cagatatgt  tctttctcc  1740
ataagatct  caaagaaaa  aacttctac  acacgtgta  attctgcgg  aaatacaga  1800
acgcaagca  cctcagcct  ccatactca  aagccattg  aatctacct  cctttccct  1860
ttttacaaa  aagtgtacc  tctagcata  ctccgacta  atacactgt  tgcgcgcct  1920
ctgtctgac  acccagagc  agaacacat  atctggact  tgtttcagc  tacattgga  1980
aatgagtat  agctcatga  agaccgaca  ttggaccag  ttatgatgt  ttctatgta  2040
ggcatctgc  aggtgaaaa  cattgacct  aaattcaaa  tcatcgtaa  tgcgtataa  2100
gatcttcct  acgctgccc  ggagacctt  aaacgtgtt  tgatcagag  agaggagtt  2160
gattccatt  tagtgttct  caactcagt  ttcatgcag  gactaaaaa  aaatatttt  2220
cagtatgcc  ccaccaggc  tcctacctt  tcaccaata  ctcacattc  tcgaagccc  2280
tacaagttc  cgagttcac  cttgcggat  cctggaggt  acatctata  gtcacccct  2340
aagagtcct  ataaaattt  agaaggtct  ccaacaccc  caaaaatga  tccaagatc  2400
agaatcttg  tctcaatcg  tgaatcatt  gggacatcc  agaagttcc  gaaaataaa  2460
cagatggtg  gtaacagtg  cagagtgct  aaaagaagt  ctgaaggcg  caatccccc  2520
aaacccctg  agaagctgc  ctttgacat  gaaggatcc  atgaagcag  cgggagtaa  2580
catctccca  cggagtcca  attccaaca  aaactggca  aaatgactt  tactcgaac  2640
cgaatgcaa  agcagaaac  gaatgatag  atggaaatc  caaacaagg  ggaaaagtg  2700
tgatctcag  accctaaca  tgtagaccc  cgggacacc  gactcgtgt  tcatggatg  2760
gactatagt  cccaggttc  gctcatgtt  tagatataa  atgtgcagg  acagctgaa  2820
atttatgtg  gtgatttgt  agccacttc  atgttgtaa  caatggtat  gaattgaca  2880
tacacagga  tgagaatct  gtgcagatc  tgccattta  aatatgaaa  cagattgtt  2940
gcatttcca  caggagcct  ctgccctca  aagtgaggc  gcctctgga  ggagtccta  3000
caactccct  acatctggc  gactacttt  cctttcctt  tggcacatg  gtgatgttt  3060
ctcttggtt  tattaattt  tatgtattt  ttaatttaa  gtgaatatc  ttagaaaat  3120
tgtcttgtc  tccaaatgc  agttgattg  ttgtccaca  tcaaccaaa  tatcttgaa  3180
cctctactg  aacagattg  tacaaactg  ggaaaagta  taatttgta  acattggac  3240
tgttttaat  ctagaatct  atgtgccat  tgtttgttt  acacatttt  cctttgaaa  3300
agaagtaaa  aaagtataa  catatgata  tgtcttact  ctgacacag  tttcatacc  3360
cagaccctc  aagaaccaa  tcttttatt  atccaactc  tactttaaa  tgaagacta  3420
tgataatac  ccaggtttg  tttttcttt  aatctttca  atcactgaa  ctttaagta  3480
ccatgtagt  cttgaaaat  aagtctggc  acaactgta  ttcagagga  cctagtaca  3540
tacaaccca  gtgcacttt  taatgtctc  gggtcctga  gaatcaaga  acaaattaa  3600
tatgttctg  aagcagacc  ttaactata  gagccttcg  tttaactat  ttctgtaag  3660
agaccgtta  ctataggag  cttcggttt  ccctcatac  agtgtctaa  cacatctca  3720
cagttcact  tgctcttct  catccaggg  tgatgtgtt  cctctggaa  ggtacatgt  3780
ttccagggt  ttttgaact  gcaggtatc  attttttta  gccaatctg  tctaataac  3840
ctggcttct  caaagccac  gcatttcta  tccagctgt  ccgaagctt  agactaaaa  3900
agctgcatt  aaagaagag  cactccctt  acccccccc  cccacctaa  ggtgtttac  3960
ttatcttgt  ggattaact  atttagaga  gctataatt  aaaataggc  gtatttaag  4020
tagcgtcag  tagcattta  gaaaatcat  ttttctaaa  tccatactt  ttgaaaaga  4080
atctggtct  gttagaaaa  aaatttcta  tttgtcctc  atttagttt  agttttact  4140
ggttgatag  tatctcgat  acaaaggcc  tagacagct  cccccattt  ttcattgag  4200
tttgcatgg  catcacaca  gttagttgg  tttaggtca  gggctgacc  tacttctag  4260
tcttttgct  gtaagttca  gttagaatt  gtgacagaa  cataggaat  ttcagagat  4320
ctctattaa  atttcttaa  actgcagac  ctgcttttg  ttttgtact  gttaaaact  4380
tacattcag  ttgctatgt  cctattttc  ataatagtt  gtctatttt  ca  4432



<210> 1858
<211> 899
<212> PRT
<213> Rattus norvegicus
<308> P33568
<400> 1858

Pro Glu Asp Asp Pro Ala Gln Asp Ser Asp Pro Glu Glu Leu Pro Leu 
  1               5                  10                  15
Ile Arg Leu Glu Phe Glu Lys Ile Glu Glu Pro Glu Phe Ile Ala Leu 
             20                  25                  30
Cys Gln Lys Leu Lys Val Pro Asp His Val Arg Glu Arg Ala Trp Leu 
         35                  40                  45
Thr Trp Glu Lys Val Ser Ser Val Asp Gly Ile Leu Glu Gly Tyr Ile 
     50                  55                  60
Gln Lys Lys Lys Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val 
 65                  70                  75                  80
Asp Leu Asp Glu Met Pro Phe Thr Phe Thr Glu Leu Gln Lys Ser Ile 
                 85                  90                  95
Glu Thr Ser Val Tyr Lys Phe Phe Asp Leu Leu Lys Glu Ile Asp Thr 
             100                105                110
Ser Thr Lys Val Asp Asn Ala Val Ser Arg Leu Leu Lys Lys Tyr Asn 
         115                120                125
Val Leu Cys Ala Leu Tyr Ser Lys Leu Glu Arg Thr Cys Gly Leu Ile 
     130                135                140
Tyr Leu Thr Gln Pro Ser Ser Gly Leu Ser Thr Glu Ile Asn Ser Met 
 145                150                155                160
Leu Val Leu Lys Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu 
                 165                170                175
Val Val Gln Met Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu 
             180                185                190
Cys Val Leu Asp Tyr Phe Ile Lys Leu Ser Pro Pro Ala Leu Leu Arg 
         195                200                205
Glu Pro Tyr Lys Thr Ala Ala Thr Pro Ile Asn Gly Ser Pro Arg Thr 
     210                215                220
Pro Arg Arg Gly Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu 
 225                230                235                240
Ser Asp Thr Arg Thr Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn 
                 245                250                255
Val Asp Glu Val Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Ile 
             260                265                270
Ser Ser Leu Gly Ile Val Ser Ser Asn Gly Leu Pro Glu Leu Glu Ser 
         275                280                285
Leu Ser Lys Arg Tyr Glu Glu Val Tyr Leu Lys Ser Lys Asp Leu Asp 
     290                295                300
Ala Arg Leu Phe Leu Asp His Asp Lys Thr Leu Gln Thr Asp Thr Ile 
 305                310                315                320
Asp Ser Phe Glu Thr Glu Arg Thr Pro Arg Lys Ser Asn Pro Asp Glu 
                 325                330                335
Glu Ala Asn Met Val Thr Pro His Thr Pro Val Arg Thr Val Met Asn 
             340                345                350
Thr Ile Gln Gln Leu Met Val Ile Leu Asn Ser Ala Ser Asp Gln Pro 
         355                360                365
Ser Glu Asn Leu Ile Ser Tyr Phe Ser Asn Cys Thr Val Asn Pro Lys 
     370                375                380
Glu Asn Ile Leu Lys Arg Val Lys Asp Val Gly His Ile Phe Lys Glu 
 385                390                395                400
Lys Phe Ala Ser Ala Val Gly Gln Gly Cys Ile Asp Ile Gly Ala Gln 
                 405                410                415
Arg Tyr Lys Leu Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met 
             420                425                430
Leu Lys Ser Glu Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu 
         435                440                445
Leu Asn Asp Asn Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu 
     450                455                460
Val Val Met Ala Thr Tyr Ser Arg Ser Met Leu Gln Asn Leu Asp Ser 
 465                470                475                480
Gly Thr Asp Leu Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys 
                 485                490                495
Ala Phe Asp Phe Tyr Lys Val Ile Glu Ser Phe Ile Lys Val Glu Ala 
             500                505                510
Asn Leu Thr Arg Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg 
         515                520                525
Ile Met Glu Ser Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu 
     530                535                540
Ile Lys Gln Ser Lys Asp Gly Glu Gly Pro Asp His Leu Glu Ser Ala 
 545                550                555                560
Cys Ser Leu Ser Leu Pro Leu Gln Ser Asn His Thr Ala Ala Asp Met 
                 565                570                575
Tyr Leu Ser Pro Ile Arg Ser Pro Lys Lys Arg Thr Ser Thr Thr Arg 
             580                585                590
Val Asn Ser Ala Ala Asn Thr Glu Thr Gln Ala Ala Ser Ala Phe His 
         595                600                605
Thr Gln Lys Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys 
     610                615                620
Val Tyr Arg Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Ala Arg Leu 
 625                630                635                640
Leu Ser Asp His Pro Glu Pro Glu His Ile Ile Trp Thr Leu Phe Gln 
                 645                650                655
His Thr Leu Glu Asn Glu Tyr Glu Leu Met Lys Asp Arg His Leu Asp 
             660                665                670
Gln Ile Met Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile 
         675                680                685
Asp Leu Lys Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His 
     690                695                700
Ala Ala Gln Glu Thr Phe Lys Arg Val Leu Ile Arg Glu Glu Glu Phe 
 705                710                715                720
Asp Ser Ile Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys 
                 725                730                735
Thr Asn Ile Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro 
             740                745                750
Ile Pro His Ile Pro Arg Ser Pro Tyr Lys Phe Ser Ser Ser Pro Leu 
         755                760                765
Arg Ile Pro Gly Gly Asn Ile Tyr Met Ser Pro Leu Lys Ser Pro Tyr 
     770                775                780
Lys Ile Ser Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser 
 785                790                795                800
Arg Ile Leu Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe 
                 805                810                815
Gln Lys Ile Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg 
             820                825                830
Ser Ala Glu Gly Gly Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe 
         835                840                845
Asp Ile Glu Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Ala 
     850                855                860
Glu Ser Lys Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr 
 865                870                875                880
Arg Met Gln Lys Gln Lys Leu Asn Asp Ser Met Glu Ile Ser Asn Lys 
                 885                890                895
Glu Glu Lys 
             900



<210> 1859
<211> 4839
<212> DNA
<213> Homo sapiens
<308> L41870
<400> 1859

tccggtttt  ctcagggga  gttgaaatt  tttttgtaa  gggagtcgg  agaggacgg  60
gcgtgcccc  cgtgcgcgc  cgtcgtcct  cccggcgct  ctccacagc  cgctggctc  120
cgccgcgga  aggcgtcat  ccgcccaaa  ccccccgaa  aacggccgc  accgccgcc  180
ctgccgccg  ggaaccccc  gcaccgccg  cgccgcccc  tcctgagga  gacccagag  240
aggacagcg  cccggagga  ctgcctctc  tcaggcttg  gtttgaaga  acagaagaa  300
ctgatttta  tgcattatg  cagaaatta  agataccag  tcatgtcag  gagagagct  360
ggttaactt  ggagaaagt  tcatctgtg  atggagtat  gggaggtta  attcaaaag  420
aaaaggaac  gtggggaat  tgtatcttt  ttgcagcag  tgacctaga  gagatgtcg  480
tcactttta  tgagctaca  aaaaacata  aaatcagtg  ccataaatt  tttaactta  540
taaaagaaa  tgataccag  accaaagtt  ataatgcta  gtcaagact  ttgaagaag  600
atgatgtat  gtttgcact  ttcagcaaa  tggaaagga  atgtgaact  atatatttg  660
cacaaccca  cagttcgat  tctactgaa  taaattctg  attggtgct  aaagtttct  720
ggatcacat  tttattagc  aaaggggaa  tattacaaa  ggaagatga  ctggtgatt  780
catttcagt  aatgctatg  gtccttgac  attttatta  actctcacc  cccatgttg  840
tcaaagaac  atataaaac  gctgttata  ccattaatg  ttcacctcg  acacccagg  900
gaggtcaga  caggagtgc  cggatagca  aacaactag  aaatgatac  agaattatt  960
aagttctct  taaagaaca  gaatgtaat  tagatgagg  gaaaaatgt  tatttcaaa  1020
attttatac  ttttatgaa  tctcttgga  ttgtaacat  taatggact  ccagaggtt  1080
aaaatcttt  taaacgata  gaagaaatt  atcttaaaa  taaagatct  gatgcaaga  1140
tatttttgg  tcatgataa  actcttcag  ctgattcta  agacagttt  gaaacacag  1200
gaacaccac  aaaaagtaa  cttgatgaa  aggtgaatg  aattcctcc  cacactcca  1260
ttaggactg  tatgaacac  atccaacaa  taatgatga  tttaaattc  gcaagtgat  1320
aaccttcag  aaatctgat  tcctatttt  acaactgca  agtgaatcc  aaagaaagt  1380
tactgaaaa  agtgaagga  ataggatac  tctttaaag  gaaatttgc  aaagctgtg  1440
gacagggtt  tgtcgaaat  ggatcacag  gatacaaac  tggagttcg  ttgtattac  1500
gagtaatgg  atccatgct  aaatcagaa  aagaacgat  atccattca  aattttagc  1560
aacttctga  tgacaacat  tttcatatg  ctttattgg  gtgcgctct  gaggttgta  1620
tggccacat  tagcagaag  acatctcag  atcttgatt  tggaacaga  ttgtctttc  1680
catggattc  gaatgtgct  aatttaaaa  cctttgatt  ttacaaagt  atcgaaagt  1740
ttatcaaag  agaaggcaa  ttgacaaga  aaatgataa  acatttaga  cgatgtgaa  1800
atcgaatca  ggaatccct  gcatggctc  cagattcac  tttatttga  cttattaaa  1860
aatcaaagg  ccgagaagg  ccaactgat  accttgaat  tgcttgtcc  cttaatctt  1920
ctctccaga  taatcacac  gcagcagat  tgtatcttt  tcctgtaag  tctccaaag  1980
aaaaaggtt  aactacgcg  gtaaattct  ctgcaaatg  agagacaca  gcaacctca  2040
ccttccaga  ccagaagcc  ttgaaatct  cctctcttt  actgtttta  aaaaaagtg  2100
atcggctag  ctatctccg  ctaaataca  tttgtgaac  ccttctgtc  gagcaccca  2160
aattagaac  tatcatctg  acccttttc  agcacaccc  gcagaatga  tatgaactc  2220
tgagagaca  gcatttgga  caaattatg  tgtgttcca  gtatggcat  tgcaaagtg  2280
agaatatag  ccttaaatt  aaaatcatt  taacagcat  caaggatct  cctcatgct  2340
ttcaggaga  attcaaacg  gttttgatc  aagaagagg  gtatgattc  attatagta  2400
tctataact  ggtcttcat  cagagactg  aaacaaata  tttgcagta  gcttccacc  2460
ggcccccta  cttgtcacc  atacctcac  ttcctcgaa  cccttacaa  tttcctagt  2520
cacccttac  gattcctgg  gggaacatc  atatttcac  cctgaagag  ccatataaa  2580
tttcagaag  tctgccaac  ccaacaaaa  tgactccaa  atcaagaat  ttagtatca  2640
ttggtgaat  attcgggac  tctgagaag  tccagaaaa  aaatcagat  gtatgtaac  2700
gcgaccgtg  gctcaaaag  agtgctgaa  gaagcaacc  tcctaaacc  ctgaaaaaa  2760
tacgctttg  tattgaagg  tcagatgaa  cagatggaa  taaacatct  ccaggagag  2820
ccaaatttc  gcagaaact  gcagaaatg  cttctactc  aacacgaat  caaaagcag  2880
aaatgaatg  tagcatgga  acctcaaac  aggaagaga  atgaggatc  caggacctt  2940
gtggacact  tgtacacct  tggattcat  gtctctcac  gatgtgact  tataacttt  3000
ccaggttct  tttatggcc  catttaata  cttcagctc  ttttgtgga  ataaaatgt  3060
cagatgcaa  tgtttgggt  attcctaag  cacttgaaa  gttagtcat  gttatttat  3120
caagattga  aatcttgtg  aaatcctgc  atttaaaaa  ttgtagcag  ttgtttcct  3180
ttccaaagt  aaattgctg  gctttatgg  tagtaagaa  ggccctaga  tgggagtcc  3240
gataaccca  gcctgtctg  ctactttgc  ttcttttgt  gcatatagg  gatgtttgc  3300
cttgttttt  ttaatttat  tgtatattt  tttaattta  catgaacac  cttagaaaa  3360
gtgtcctat  tatcttcca  atgcaattt  attgactgc  cattcacca  aattatcct  3420
aactcttct  caaaaatgg  tattattag  aattagaaa  aaattacta  ttttacaca  3480
tagatttta  tttactatt  gaatctgat  tactgtgtg  ttgttttat  aaattttgc  3540
tttaattaa  taaaagctg  aagcaaagt  taaccatat  atactatca  actactgaa  3600
cagatttca  acctcagaa  gtaaaagaa  ttactgatt  ttttcttca  ccaacttat  3660
tttttaaat  aggattatt  atagtactc  tggttttta  accattcag  tcactgaat  3720
tataaagta  ccatctagt  cttgaaaaa  taaagtgtt  tgccagatc  taggtatag  3780
ggaccctaa  acagtatat  ccaagtgca  tttctaatg  ttctgggtc  tgaagaatt  3840
agatacaaa  taattttac  ccataaaca  actgttaat  ataggagcc  taatttttt  3900
ttcatagag  tttgtctaa  tgcatctca  aattattct  ccctcctta  tttgggaag  3960
tttgtgttt  ctctggaat  gtacatgtc  tccatgtat  ttttgaact  gcaattgtc  4020
atttatctt  tattttttt  agtcagtat  gtctaacac  ggcatgttc  aagccacat  4080
atttctagt  caaaattac  agtaatcaa  ggtcattat  ggttaggca  taatgtttc  4140
atctgattt  gtgcaaaag  ttcaaatta  aacagctgc  ttagaaaaa  aggcgcttc  4200
cccctcccc  acacctaaa  gtgtattta  actatcttg  gtgattaac  tatttagag  4260
tgctgtaac  taaaatagg  gatatttaa  gtagcttca  ctagctttt  ggaaaatca  4320
tttgtctaa  tcagaatta  ttttaaaaa  aaatctggt  ttgttagaa  acaaaattt  4380
attttgtgc  catttaagt  tcaaactta  tattttgac  gttattttg  taacaatga  4440
actagaaaa  ttgactcca  ttcatcatt  tttctgcat  aatatcata  aaatcagtt  4500
gtttttagg  caagggctt  ctatttctg  gtcttttgc  actaagttc  cattagaat  4560
agtgccaga  ttttaggaa  ttcagagat  gtgtattga  atttcttaa  taatgcttc  4620
gatattatt  ctttattgc  tttttgtat  ggttaaaac  gtacattta  aattgctat  4680
ttactattt  ctacaatta  tagtttgtc  attttaaaa  aaattagtt  ttaagagtc  4740
taatggtct  atgttgtgt  ctttgtatt  agtacacta  tgttctctt  tctgtctag  4800
agaagatag  tagaagata  ctctcctag  atctcatcc  4839



<210> 1860
<211> 928
<212> PRT
<213> Homo sapiens
<308> P06400
<400> 1860

Met Pro Pro Lys Thr Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala 
  1               5                  10                  15
Ala Ala Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp 
             20                  25                  30
Pro Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu 
         35                  40                  45
Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu 
     50                  55                  60
Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys 
 65                  70                  75                  80
Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys Lys Lys 
                 85                  90                  95
Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val Asp Leu Asp Glu 
             100                105                110
Met Ser Phe Thr Phe Thr Glu Leu Gln Lys Asn Ile Glu Ile Ser Val 
         115                120                125
His Lys Phe Phe Asn Leu Leu Lys Glu Ile Asp Thr Ser Thr Lys Val 
     130                135                140
Asp Asn Ala Met Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala 
 145                150                155                160
Leu Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln 
                 165                170                175
Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys 
             180                185                190
Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met 
         195                200                205
Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val Leu Asp 
     210                215                220
Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys Glu Pro Tyr Lys 
 225                230                235                240
Thr Ala Val Ile Pro Ile Asn Gly Ser Pro Arg Thr Pro Arg Arg Gly 
                 245                250                255
Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg 
             260                265                270
Ile Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val 
         275                280                285
Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly 
     290                295                300
Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg 
 305                310                315                320
Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe 
                 325                330                335
Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp Ser Phe Glu 
             340                345                350
Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp Glu Glu Val Asn Val 
         355                360                365
Ile Pro Pro His Thr Pro Val Arg Thr Val Met Asn Thr Ile Gln Gln 
     370                375                380
Leu Met Met Ile Leu Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu 
 385                390                395                400
Ile Ser Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu 
                 405                410                415
Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys 
             420                425                430
Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu 
         435                440                445
Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser Glu 
     450                455                460
Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn 
 465                470                475                480
Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu Val Val Met Ala 
                 485                490                495
Thr Tyr Ser Arg Ser Thr Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu 
             500                505                510
Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe 
         515                520                525
Tyr Lys Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg 
     530                535                540
Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser 
 545                550                555                560
Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser 
                 565                570                575
Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys Pro Leu 
             580                585                590
Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp Met Tyr Leu Ser 
         595                600                605
Pro Val Arg Ser Pro Lys Lys Lys Gly Ser Thr Thr Arg Val Asn Ser 
     610                615                620
Thr Ala Asn Ala Glu Thr Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys 
 625                630                635                640
Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg 
                 645                650                655
Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu 
             660                665                670
His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu 
         675                680                685
Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met 
     690                695                700
Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp Leu Lys 
 705                710                715                720
Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His Ala Val Gln 
                 725                730                735
Glu Thr Phe Lys Arg Val Leu Ile Lys Glu Glu Glu Tyr Asp Ser Ile 
             740                745                750
Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile 
         755                760                765
Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His 
     770                775                780
Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro 
 785                790                795                800
Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile Ser 
                 805                810                815
Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser Arg Ile Leu 
             820                825                830
Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys Ile 
         835                840                845
Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala Glu 
     850                855                860
Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe Asp Ile Glu 
 865                870                875                880
Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys 
                 885                890                895
Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln 
             900                905                910
Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys 
         915                920                925



<210> 1861
<211> 4432
<212> DNA
<213> Rattus norvegicus
<308> D25233
<400> 1861

ccggaggac  accccgcgc  ggacagtga  cccgaagag  tgcccctga  caggcttga  60
tttgaaaaa  ttgaagaac  tgaatttat  gcattatgt  agaagttaa  ggtgcccga  120
catgtcaga  agagagctt  gctaacgtg  gagaaagtt  catctgtgg  tggaatcct  180
gaaggatat  ttcagaaga  gaaggaact  tggggcatc  gcatcttca  tgcagcagt  240
gacctggat  agatgccat  cacttttac  gagcttcag  aaagcatag  aaccagtgt  300
tataaattc  ttgacttat  aaaagaaat  gataccagt  ccaaagttg  taatgctgt  360
tcaaggcta  tgaagaagt  caatgtgtt  tgtgcactc  acagcaaat  agaacggac  420
tgtggactt  tatatttga  acagcccag  agtgggtta  ctactgaaa  aaattctat  480
ttggtgcta  aagtttctt  gatcacctt  ttactagct  aaggagaag  agtacagat  540
gaagatgat  tggtgatct  atttcagtt  atgttgtgt  tacttgact  ttttatcaa  600
ctctcgcct  ctgcgctgc  cagagagcc  tacaaaaca  ctgcaacac  cattaatgg  660
tcacctcgg  cacccagaa  aggtcagaa  aggagtgct  ggatagcaa  acaactaga  720
agtgataca  gaactattg  agttctctg  aaggagcac  agtgtaatg  agatgaggt  780
aaaaatgtt  atttcaaaa  ttttatccc  tttataagt  cacttggaa  tgtatcatc  840
aatggactt  cagagcttg  aagtctttc  aaacgctac  aagaagttt  tcttaaaag  900
aaagattta  atgcaagac  atttttgga  catgacaaa  cacttcaga  tgatactat  960
gacagtttt  aaacagaga  aactccacg  aaaagcaac  ctgatgaag  ggcaaacat  1020
gttactcca  acactccag  taggactgt  atgaatact  ttcaacagt  aatggtgat  1080
ttaaattct  caagtgatc  gccatcaga  aatctgatt  cctacttca  taattgcac  1140
gtgaatcca  aagaaaata  cctaaaaag  gtaaaggat  ttggacaca  ctttaaaga  1200
aagtttgct  gcgctgtgg  gcagggatg  attgacatt  gagcacagc  atataaact  1260
ggggttcga  tgtattatc  tgtgatgga  tcgatgctt  aatcagaag  agaacgttt  1320
tccattcag  attttagca  actcctaaa  gacaacatc  ttcatatgt  tttattggc  1380
tgtgctctt  aagttgtaa  ggctacata  agcaggagt  tgttacaga  tcttgattc  1440
ggaacagat  tgtccttcc  gtggattct  aatgtactt  atttaaaag  ctttgattt  1500
tacaaagtg  ttgaaagtt  tatcaaagt  gaagccaac  tgacaagag  aatgataaa  1560
catttagaa  gatgtgagc  tcgaatcat  gaatccctt  catggcttt  tgattcacc  1620
ttgtttgat  tcataaagc  gtccaagga  ggggaagga  ctgatcacc  tgagtctgc  1680
tgttctctc  gcctccctc  ccagagtaa  cacactgca  cagatatgt  tctttctcc  1740
ataagatct  caaagaaaa  aacttctac  acacgtgta  attctgcgg  aaatacaga  1800
acgcaagca  cctcagcct  ccatactca  aagccattg  aatctacct  cctttccct  1860
ttttacaaa  aagtgtacc  tctagcata  ctccgacta  atacactgt  tgcgcgcct  1920
ctgtctgac  acccagagc  agaacacat  atctggact  tgtttcagc  tacattgga  1980
aatgagtat  agctcatga  agaccgaca  ttggaccag  ttatgatgt  ttctatgta  2040
ggcatctgc  aggtgaaaa  cattgacct  aaattcaaa  tcatcgtaa  tgcgtataa  2100
gatcttcct  acgctgccc  ggagacctt  aaacgtgtt  tgatcagag  agaggagtt  2160
gattccatt  tagtgttct  caactcagt  ttcatgcag  gactaaaaa  aaatatttt  2220
cagtatgcc  ccaccaggc  tcctacctt  tcaccaata  ctcacattc  tcgaagccc  2280
tacaagttc  cgagttcac  cttgcggat  cctggaggt  acatctata  gtcacccct  2340
aagagtcct  ataaaattt  agaaggtct  ccaacaccc  caaaaatga  tccaagatc  2400
agaatcttg  tctcaatcg  tgaatcatt  gggacatcc  agaagttcc  gaaaataaa  2460
cagatggtg  gtaacagtg  cagagtgct  aaaagaagt  ctgaaggcg  caatccccc  2520
aaacccctg  agaagctgc  ctttgacat  gaaggatcc  atgaagcag  cgggagtaa  2580
catctccca  cggagtcca  attccaaca  aaactggca  aaatgactt  tactcgaac  2640
cgaatgcaa  agcagaaac  gaatgatag  atggaaatc  caaacaagg  ggaaaagtg  2700
tgatctcag  accctaaca  tgtagaccc  cgggacacc  gactcgtgt  tcatggatg  2760
gactatagt  cccaggttc  gctcatgtt  tagatataa  atgtgcagg  acagctgaa  2820
atttatgtg  gtgatttgt  agccacttc  atgttgtaa  caatggtat  gaattgaca  2880
tacacagga  tgagaatct  gtgcagatc  tgccattta  aatatgaaa  cagattgtt  2940
gcatttcca  caggagcct  ctgccctca  aagtgaggc  gcctctgga  ggagtccta  3000
caactccct  acatctggc  gactacttt  cctttcctt  tggcacatg  gtgatgttt  3060
ctcttggtt  tattaattt  tatgtattt  ttaatttaa  gtgaatatc  ttagaaaat  3120
tgtcttgtc  tccaaatgc  agttgattg  ttgtccaca  tcaaccaaa  tatcttgaa  3180
cctctactg  aacagattg  tacaaactg  ggaaaagta  taatttgta  acattggac  3240
tgttttaat  ctagaatct  atgtgccat  tgtttgttt  acacatttt  cctttgaaa  3300
agaagtaaa  aaagtataa  catatgata  tgtcttact  ctgacacag  tttcatacc  3360
cagaccctc  aagaaccaa  tcttttatt  atccaactc  tactttaaa  tgaagacta  3420
tgataatac  ccaggtttg  tttttcttt  aatctttca  atcactgaa  ctttaagta  3480
ccatgtagt  cttgaaaat  aagtctggc  acaactgta  ttcagagga  cctagtaca  3540
tacaaccca  gtgcacttt  taatgtctc  gggtcctga  gaatcaaga  acaaattaa  3600
tatgttctg  aagcagacc  ttaactata  gagccttcg  tttaactat  ttctgtaag  3660
agaccgtta  ctataggag  cttcggttt  ccctcatac  agtgtctaa  cacatctca  3720
cagttcact  tgctcttct  catccaggg  tgatgtgtt  cctctggaa  ggtacatgt  3780
ttccagggt  ttttgaact  gcaggtatc  attttttta  gccaatctg  tctaataac  3840
ctggcttct  caaagccac  gcatttcta  tccagctgt  ccgaagctt  agactaaaa  3900
agctgcatt  aaagaagag  cactccctt  acccccccc  cccacctaa  ggtgtttac  3960
ttatcttgt  ggattaact  atttagaga  gctataatt  aaaataggc  gtatttaag  4020
tagcgtcag  tagcattta  gaaaatcat  ttttctaaa  tccatactt  ttgaaaaga  4080
atctggtct  gttagaaaa  aaatttcta  tttgtcctc  atttagttt  agttttact  4140
ggttgatag  tatctcgat  acaaaggcc  tagacagct  cccccattt  ttcattgag  4200
tttgcatgg  catcacaca  gttagttgg  tttaggtca  gggctgacc  tacttctag  4260
tcttttgct  gtaagttca  gttagaatt  gtgacagaa  cataggaat  ttcagagat  4320
ctctattaa  atttcttaa  actgcagac  ctgcttttg  ttttgtact  gttaaaact  4380
tacattcag  ttgctatgt  cctattttc  ataatagtt  gtctatttt  ca  4432



<210> 1862
<211> 899
<212> PRT
<213> Rattus norvegicus
<308> P33568
<400> 1862

Pro Glu Asp Asp Pro Ala Gln Asp Ser Asp Pro Glu Glu Leu Pro Leu 
  1               5                  10                  15
Ile Arg Leu Glu Phe Glu Lys Ile Glu Glu Pro Glu Phe Ile Ala Leu 
             20                  25                  30
Cys Gln Lys Leu Lys Val Pro Asp His Val Arg Glu Arg Ala Trp Leu 
         35                  40                  45
Thr Trp Glu Lys Val Ser Ser Val Asp Gly Ile Leu Glu Gly Tyr Ile 
     50                  55                  60
Gln Lys Lys Lys Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val 
 65                  70                  75                  80
Asp Leu Asp Glu Met Pro Phe Thr Phe Thr Glu Leu Gln Lys Ser Ile 
                 85                  90                  95
Glu Thr Ser Val Tyr Lys Phe Phe Asp Leu Leu Lys Glu Ile Asp Thr 
             100                105                110
Ser Thr Lys Val Asp Asn Ala Val Ser Arg Leu Leu Lys Lys Tyr Asn 
         115                120                125
Val Leu Cys Ala Leu Tyr Ser Lys Leu Glu Arg Thr Cys Gly Leu Ile 
     130                135                140
Tyr Leu Thr Gln Pro Ser Ser Gly Leu Ser Thr Glu Ile Asn Ser Met 
 145                150                155                160
Leu Val Leu Lys Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu 
                 165                170                175
Val Val Gln Met Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu 
             180                185                190
Cys Val Leu Asp Tyr Phe Ile Lys Leu Ser Pro Pro Ala Leu Leu Arg 
         195                200                205
Glu Pro Tyr Lys Thr Ala Ala Thr Pro Ile Asn Gly Ser Pro Arg Thr 
     210                215                220
Pro Arg Arg Gly Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu 
 225                230                235                240
Ser Asp Thr Arg Thr Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn 
                 245                250                255
Val Asp Glu Val Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Ile 
             260                265                270
Ser Ser Leu Gly Ile Val Ser Ser Asn Gly Leu Pro Glu Leu Glu Ser 
         275                280                285
Leu Ser Lys Arg Tyr Glu Glu Val Tyr Leu Lys Ser Lys Asp Leu Asp 
     290                295                300
Ala Arg Leu Phe Leu Asp His Asp Lys Thr Leu Gln Thr Asp Thr Ile 
 305                310                315                320
Asp Ser Phe Glu Thr Glu Arg Thr Pro Arg Lys Ser Asn Pro Asp Glu 
                 325                330                335
Glu Ala Asn Met Val Thr Pro His Thr Pro Val Arg Thr Val Met Asn 
             340                345                350
Thr Ile Gln Gln Leu Met Val Ile Leu Asn Ser Ala Ser Asp Gln Pro 
         355                360                365
Ser Glu Asn Leu Ile Ser Tyr Phe Ser Asn Cys Thr Val Asn Pro Lys 
     370                375                380
Glu Asn Ile Leu Lys Arg Val Lys Asp Val Gly His Ile Phe Lys Glu 
 385                390                395                400
Lys Phe Ala Ser Ala Val Gly Gln Gly Cys Ile Asp Ile Gly Ala Gln 
                 405                410                415
Arg Tyr Lys Leu Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met 
             420                425                430
Leu Lys Ser Glu Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu 
         435                440                445
Leu Asn Asp Asn Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu 
     450                455                460
Val Val Met Ala Thr Tyr Ser Arg Ser Met Leu Gln Asn Leu Asp Ser 
 465                470                475                480
Gly Thr Asp Leu Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys 
                 485                490                495
Ala Phe Asp Phe Tyr Lys Val Ile Glu Ser Phe Ile Lys Val Glu Ala 
             500                505                510
Asn Leu Thr Arg Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg 
         515                520                525
Ile Met Glu Ser Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu 
     530                535                540
Ile Lys Gln Ser Lys Asp Gly Glu Gly Pro Asp His Leu Glu Ser Ala 
 545                550                555                560
Cys Ser Leu Ser Leu Pro Leu Gln Ser Asn His Thr Ala Ala Asp Met 
                 565                570                575
Tyr Leu Ser Pro Ile Arg Ser Pro Lys Lys Arg Thr Ser Thr Thr Arg 
             580                585                590
Val Asn Ser Ala Ala Asn Thr Glu Thr Gln Ala Ala Ser Ala Phe His 
         595                600                605
Thr Gln Lys Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys 
     610                615                620
Val Tyr Arg Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Ala Arg Leu 
 625                630                635                640
Leu Ser Asp His Pro Glu Pro Glu His Ile Ile Trp Thr Leu Phe Gln 
                 645                650                655
His Thr Leu Glu Asn Glu Tyr Glu Leu Met Lys Asp Arg His Leu Asp 
             660                665                670
Gln Ile Met Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile 
         675                680                685
Asp Leu Lys Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His 
     690                695                700
Ala Ala Gln Glu Thr Phe Lys Arg Val Leu Ile Arg Glu Glu Glu Phe 
 705                710                715                720
Asp Ser Ile Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys 
                 725                730                735
Thr Asn Ile Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro 
             740                745                750
Ile Pro His Ile Pro Arg Ser Pro Tyr Lys Phe Ser Ser Ser Pro Leu 
         755                760                765
Arg Ile Pro Gly Gly Asn Ile Tyr Met Ser Pro Leu Lys Ser Pro Tyr 
     770                775                780
Lys Ile Ser Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser 
 785                790                795                800
Arg Ile Leu Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe 
                 805                810                815
Gln Lys Ile Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg 
             820                825                830
Ser Ala Glu Gly Gly Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe 
         835                840                845
Asp Ile Glu Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Ala 
     850                855                860
Glu Ser Lys Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr 
 865                870                875                880
Arg Met Gln Lys Gln Lys Leu Asn Asp Ser Met Glu Ile Ser Asn Lys 
                 885                890                895
Glu Glu Lys 
             900



<210> 1863
<211> 4839
<212> DNA
<213> Homo sapiens
<308> L41870
<400> 1863

tccggtttt  ctcagggga  gttgaaatt  tttttgtaa  gggagtcgg  agaggacgg  60
gcgtgcccc  cgtgcgcgc  cgtcgtcct  cccggcgct  ctccacagc  cgctggctc  120
cgccgcgga  aggcgtcat  ccgcccaaa  ccccccgaa  aacggccgc  accgccgcc  180
ctgccgccg  ggaaccccc  gcaccgccg  cgccgcccc  tcctgagga  gacccagag  240
aggacagcg  cccggagga  ctgcctctc  tcaggcttg  gtttgaaga  acagaagaa  300
ctgatttta  tgcattatg  cagaaatta  agataccag  tcatgtcag  gagagagct  360
ggttaactt  ggagaaagt  tcatctgtg  atggagtat  gggaggtta  attcaaaag  420
aaaaggaac  gtggggaat  tgtatcttt  ttgcagcag  tgacctaga  gagatgtcg  480
tcactttta  tgagctaca  aaaaacata  aaatcagtg  ccataaatt  tttaactta  540
taaaagaaa  tgataccag  accaaagtt  ataatgcta  gtcaagact  ttgaagaag  600
atgatgtat  gtttgcact  ttcagcaaa  tggaaagga  atgtgaact  atatatttg  660
cacaaccca  cagttcgat  tctactgaa  taaattctg  attggtgct  aaagtttct  720
ggatcacat  tttattagc  aaaggggaa  tattacaaa  ggaagatga  ctggtgatt  780
catttcagt  aatgctatg  gtccttgac  attttatta  actctcacc  cccatgttg  840
tcaaagaac  atataaaac  gctgttata  ccattaatg  ttcacctcg  acacccagg  900
gaggtcaga  caggagtgc  cggatagca  aacaactag  aaatgatac  agaattatt  960
aagttctct  taaagaaca  gaatgtaat  tagatgagg  gaaaaatgt  tatttcaaa  1020
attttatac  ttttatgaa  tctcttgga  ttgtaacat  taatggact  ccagaggtt  1080
aaaatcttt  taaacgata  gaagaaatt  atcttaaaa  taaagatct  gatgcaaga  1140
tatttttgg  tcatgataa  actcttcag  ctgattcta  agacagttt  gaaacacag  1200
gaacaccac  aaaaagtaa  cttgatgaa  aggtgaatg  aattcctcc  cacactcca  1260
ttaggactg  tatgaacac  atccaacaa  taatgatga  tttaaattc  gcaagtgat  1320
aaccttcag  aaatctgat  tcctatttt  acaactgca  agtgaatcc  aaagaaagt  1380
tactgaaaa  agtgaagga  ataggatac  tctttaaag  gaaatttgc  aaagctgtg  1440
gacagggtt  tgtcgaaat  ggatcacag  gatacaaac  tggagttcg  ttgtattac  1500
gagtaatgg  atccatgct  aaatcagaa  aagaacgat  atccattca  aattttagc  1560
aacttctga  tgacaacat  tttcatatg  ctttattgg  gtgcgctct  gaggttgta  1620
tggccacat  tagcagaag  acatctcag  atcttgatt  tggaacaga  ttgtctttc  1680
catggattc  gaatgtgct  aatttaaaa  cctttgatt  ttacaaagt  atcgaaagt  1740
ttatcaaag  agaaggcaa  ttgacaaga  aaatgataa  acatttaga  cgatgtgaa  1800
atcgaatca  ggaatccct  gcatggctc  cagattcac  tttatttga  cttattaaa  1860
aatcaaagg  ccgagaagg  ccaactgat  accttgaat  tgcttgtcc  cttaatctt  1920
ctctccaga  taatcacac  gcagcagat  tgtatcttt  tcctgtaag  tctccaaag  1980
aaaaaggtt  aactacgcg  gtaaattct  ctgcaaatg  agagacaca  gcaacctca  2040
ccttccaga  ccagaagcc  ttgaaatct  cctctcttt  actgtttta  aaaaaagtg  2100
atcggctag  ctatctccg  ctaaataca  tttgtgaac  ccttctgtc  gagcaccca  2160
aattagaac  tatcatctg  acccttttc  agcacaccc  gcagaatga  tatgaactc  2220
tgagagaca  gcatttgga  caaattatg  tgtgttcca  gtatggcat  tgcaaagtg  2280
agaatatag  ccttaaatt  aaaatcatt  taacagcat  caaggatct  cctcatgct  2340
ttcaggaga  attcaaacg  gttttgatc  aagaagagg  gtatgattc  attatagta  2400
tctataact  ggtcttcat  cagagactg  aaacaaata  tttgcagta  gcttccacc  2460
ggcccccta  cttgtcacc  atacctcac  ttcctcgaa  cccttacaa  tttcctagt  2520
cacccttac  gattcctgg  gggaacatc  atatttcac  cctgaagag  ccatataaa  2580
tttcagaag  tctgccaac  ccaacaaaa  tgactccaa  atcaagaat  ttagtatca  2640
ttggtgaat  attcgggac  tctgagaag  tccagaaaa  aaatcagat  gtatgtaac  2700
gcgaccgtg  gctcaaaag  agtgctgaa  gaagcaacc  tcctaaacc  ctgaaaaaa  2760
tacgctttg  tattgaagg  tcagatgaa  cagatggaa  taaacatct  ccaggagag  2820
ccaaatttc  gcagaaact  gcagaaatg  cttctactc  aacacgaat  caaaagcag  2880
aaatgaatg  tagcatgga  acctcaaac  aggaagaga  atgaggatc  caggacctt  2940
gtggacact  tgtacacct  tggattcat  gtctctcac  gatgtgact  tataacttt  3000
ccaggttct  tttatggcc  catttaata  cttcagctc  ttttgtgga  ataaaatgt  3060
cagatgcaa  tgtttgggt  attcctaag  cacttgaaa  gttagtcat  gttatttat  3120
caagattga  aatcttgtg  aaatcctgc  atttaaaaa  ttgtagcag  ttgtttcct  3180
ttccaaagt  aaattgctg  gctttatgg  tagtaagaa  ggccctaga  tgggagtcc  3240
gataaccca  gcctgtctg  ctactttgc  ttcttttgt  gcatatagg  gatgtttgc  3300
cttgttttt  ttaatttat  tgtatattt  tttaattta  catgaacac  cttagaaaa  3360
gtgtcctat  tatcttcca  atgcaattt  attgactgc  cattcacca  aattatcct  3420
aactcttct  caaaaatgg  tattattag  aattagaaa  aaattacta  ttttacaca  3480
tagatttta  tttactatt  gaatctgat  tactgtgtg  ttgttttat  aaattttgc  3540
tttaattaa  taaaagctg  aagcaaagt  taaccatat  atactatca  actactgaa  3600
cagatttca  acctcagaa  gtaaaagaa  ttactgatt  ttttcttca  ccaacttat  3660
tttttaaat  aggattatt  atagtactc  tggttttta  accattcag  tcactgaat  3720
tataaagta  ccatctagt  cttgaaaaa  taaagtgtt  tgccagatc  taggtatag  3780
ggaccctaa  acagtatat  ccaagtgca  tttctaatg  ttctgggtc  tgaagaatt  3840
agatacaaa  taattttac  ccataaaca  actgttaat  ataggagcc  taatttttt  3900
ttcatagag  tttgtctaa  tgcatctca  aattattct  ccctcctta  tttgggaag  3960
tttgtgttt  ctctggaat  gtacatgtc  tccatgtat  ttttgaact  gcaattgtc  4020
atttatctt  tattttttt  agtcagtat  gtctaacac  ggcatgttc  aagccacat  4080
atttctagt  caaaattac  agtaatcaa  ggtcattat  ggttaggca  taatgtttc  4140
atctgattt  gtgcaaaag  ttcaaatta  aacagctgc  ttagaaaaa  aggcgcttc  4200
cccctcccc  acacctaaa  gtgtattta  actatcttg  gtgattaac  tatttagag  4260
tgctgtaac  taaaatagg  gatatttaa  gtagcttca  ctagctttt  ggaaaatca  4320
tttgtctaa  tcagaatta  ttttaaaaa  aaatctggt  ttgttagaa  acaaaattt  4380
attttgtgc  catttaagt  tcaaactta  tattttgac  gttattttg  taacaatga  4440
actagaaaa  ttgactcca  ttcatcatt  tttctgcat  aatatcata  aaatcagtt  4500
gtttttagg  caagggctt  ctatttctg  gtcttttgc  actaagttc  cattagaat  4560
agtgccaga  ttttaggaa  ttcagagat  gtgtattga  atttcttaa  taatgcttc  4620
gatattatt  ctttattgc  tttttgtat  ggttaaaac  gtacattta  aattgctat  4680
ttactattt  ctacaatta  tagtttgtc  attttaaaa  aaattagtt  ttaagagtc  4740
taatggtct  atgttgtgt  ctttgtatt  agtacacta  tgttctctt  tctgtctag  4800
agaagatag  tagaagata  ctctcctag  atctcatcc  4839



<210> 1864
<211> 928
<212> PRT
<213> Homo sapiens
<308> P06400
<400> 1864

Met Pro Pro Lys Thr Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala 
  1               5                  10                  15
Ala Ala Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp 
             20                  25                  30
Pro Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu 
         35                  40                  45
Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu 
     50                  55                  60
Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys 
 65                  70                  75                  80
Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys Lys Lys 
                 85                  90                  95
Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val Asp Leu Asp Glu 
             100                105                110
Met Ser Phe Thr Phe Thr Glu Leu Gln Lys Asn Ile Glu Ile Ser Val 
         115                120                125
His Lys Phe Phe Asn Leu Leu Lys Glu Ile Asp Thr Ser Thr Lys Val 
     130                135                140
Asp Asn Ala Met Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala 
 145                150                155                160
Leu Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln 
                 165                170                175
Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys 
             180                185                190
Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met 
         195                200                205
Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val Leu Asp 
     210                215                220
Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys Glu Pro Tyr Lys 
 225                230                235                240
Thr Ala Val Ile Pro Ile Asn Gly Ser Pro Arg Thr Pro Arg Arg Gly 
                 245                250                255
Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg 
             260                265                270
Ile Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val 
         275                280                285
Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly 
     290                295                300
Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg 
 305                310                315                320
Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe 
                 325                330                335
Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp Ser Phe Glu 
             340                345                350
Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp Glu Glu Val Asn Val 
         355                360                365
Ile Pro Pro His Thr Pro Val Arg Thr Val Met Asn Thr Ile Gln Gln 
     370                375                380
Leu Met Met Ile Leu Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu 
 385                390                395                400
Ile Ser Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu 
                 405                410                415
Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys 
             420                425                430
Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu 
         435                440                445
Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser Glu 
     450                455                460
Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn 
 465                470                475                480
Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu Val Val Met Ala 
                 485                490                495
Thr Tyr Ser Arg Ser Thr Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu 
             500                505                510
Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe 
         515                520                525
Tyr Lys Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg 
     530                535                540
Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser 
 545                550                555                560
Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser 
                 565                570                575
Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys Pro Leu 
             580                585                590
Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp Met Tyr Leu Ser 
         595                600                605
Pro Val Arg Ser Pro Lys Lys Lys Gly Ser Thr Thr Arg Val Asn Ser 
     610                615                620
Thr Ala Asn Ala Glu Thr Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys 
 625                630                635                640
Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg 
                 645                650                655
Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu 
             660                665                670
His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu 
         675                680                685
Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met 
     690                695                700
Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp Leu Lys 
 705                710                715                720
Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His Ala Val Gln 
                 725                730                735
Glu Thr Phe Lys Arg Val Leu Ile Lys Glu Glu Glu Tyr Asp Ser Ile 
             740                745                750
Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile 
         755                760                765
Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His 
     770                775                780
Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro 
 785                790                795                800
Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile Ser 
                 805                810                815
Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser Arg Ile Leu 
             820                825                830
Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys Ile 
         835                840                845
Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala Glu 
     850                855                860
Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe Asp Ile Glu 
 865                870                875                880
Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys 
                 885                890                895
Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln 
             900                905                910
Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys 
         915                920                925



<210> 1865
<211> 4432
<212> DNA
<213> Rattus norvegicus
<308> D25233
<400> 1865

ccggaggac  accccgcgc  ggacagtga  cccgaagag  tgcccctga  caggcttga  60
tttgaaaaa  ttgaagaac  tgaatttat  gcattatgt  agaagttaa  ggtgcccga  120
catgtcaga  agagagctt  gctaacgtg  gagaaagtt  catctgtgg  tggaatcct  180
gaaggatat  ttcagaaga  gaaggaact  tggggcatc  gcatcttca  tgcagcagt  240
gacctggat  agatgccat  cacttttac  gagcttcag  aaagcatag  aaccagtgt  300
tataaattc  ttgacttat  aaaagaaat  gataccagt  ccaaagttg  taatgctgt  360
tcaaggcta  tgaagaagt  caatgtgtt  tgtgcactc  acagcaaat  agaacggac  420
tgtggactt  tatatttga  acagcccag  agtgggtta  ctactgaaa  aaattctat  480
ttggtgcta  aagtttctt  gatcacctt  ttactagct  aaggagaag  agtacagat  540
gaagatgat  tggtgatct  atttcagtt  atgttgtgt  tacttgact  ttttatcaa  600
ctctcgcct  ctgcgctgc  cagagagcc  tacaaaaca  ctgcaacac  cattaatgg  660
tcacctcgg  cacccagaa  aggtcagaa  aggagtgct  ggatagcaa  acaactaga  720
agtgataca  gaactattg  agttctctg  aaggagcac  agtgtaatg  agatgaggt  780
aaaaatgtt  atttcaaaa  ttttatccc  tttataagt  cacttggaa  tgtatcatc  840
aatggactt  cagagcttg  aagtctttc  aaacgctac  aagaagttt  tcttaaaag  900
aaagattta  atgcaagac  atttttgga  catgacaaa  cacttcaga  tgatactat  960
gacagtttt  aaacagaga  aactccacg  aaaagcaac  ctgatgaag  ggcaaacat  1020
gttactcca  acactccag  taggactgt  atgaatact  ttcaacagt  aatggtgat  1080
ttaaattct  caagtgatc  gccatcaga  aatctgatt  cctacttca  taattgcac  1140
gtgaatcca  aagaaaata  cctaaaaag  gtaaaggat  ttggacaca  ctttaaaga  1200
aagtttgct  gcgctgtgg  gcagggatg  attgacatt  gagcacagc  atataaact  1260
ggggttcga  tgtattatc  tgtgatgga  tcgatgctt  aatcagaag  agaacgttt  1320
tccattcag  attttagca  actcctaaa  gacaacatc  ttcatatgt  tttattggc  1380
tgtgctctt  aagttgtaa  ggctacata  agcaggagt  tgttacaga  tcttgattc  1440
ggaacagat  tgtccttcc  gtggattct  aatgtactt  atttaaaag  ctttgattt  1500
tacaaagtg  ttgaaagtt  tatcaaagt  gaagccaac  tgacaagag  aatgataaa  1560
catttagaa  gatgtgagc  tcgaatcat  gaatccctt  catggcttt  tgattcacc  1620
ttgtttgat  tcataaagc  gtccaagga  ggggaagga  ctgatcacc  tgagtctgc  1680
tgttctctc  gcctccctc  ccagagtaa  cacactgca  cagatatgt  tctttctcc  1740
ataagatct  caaagaaaa  aacttctac  acacgtgta  attctgcgg  aaatacaga  1800
acgcaagca  cctcagcct  ccatactca  aagccattg  aatctacct  cctttccct  1860
ttttacaaa  aagtgtacc  tctagcata  ctccgacta  atacactgt  tgcgcgcct  1920
ctgtctgac  acccagagc  agaacacat  atctggact  tgtttcagc  tacattgga  1980
aatgagtat  agctcatga  agaccgaca  ttggaccag  ttatgatgt  ttctatgta  2040
ggcatctgc  aggtgaaaa  cattgacct  aaattcaaa  tcatcgtaa  tgcgtataa  2100
gatcttcct  acgctgccc  ggagacctt  aaacgtgtt  tgatcagag  agaggagtt  2160
gattccatt  tagtgttct  caactcagt  ttcatgcag  gactaaaaa  aaatatttt  2220
cagtatgcc  ccaccaggc  tcctacctt  tcaccaata  ctcacattc  tcgaagccc  2280
tacaagttc  cgagttcac  cttgcggat  cctggaggt  acatctata  gtcacccct  2340
aagagtcct  ataaaattt  agaaggtct  ccaacaccc  caaaaatga  tccaagatc  2400
agaatcttg  tctcaatcg  tgaatcatt  gggacatcc  agaagttcc  gaaaataaa  2460
cagatggtg  gtaacagtg  cagagtgct  aaaagaagt  ctgaaggcg  caatccccc  2520
aaacccctg  agaagctgc  ctttgacat  gaaggatcc  atgaagcag  cgggagtaa  2580
catctccca  cggagtcca  attccaaca  aaactggca  aaatgactt  tactcgaac  2640
cgaatgcaa  agcagaaac  gaatgatag  atggaaatc  caaacaagg  ggaaaagtg  2700
tgatctcag  accctaaca  tgtagaccc  cgggacacc  gactcgtgt  tcatggatg  2760
gactatagt  cccaggttc  gctcatgtt  tagatataa  atgtgcagg  acagctgaa  2820
atttatgtg  gtgatttgt  agccacttc  atgttgtaa  caatggtat  gaattgaca  2880
tacacagga  tgagaatct  gtgcagatc  tgccattta  aatatgaaa  cagattgtt  2940
gcatttcca  caggagcct  ctgccctca  aagtgaggc  gcctctgga  ggagtccta  3000
caactccct  acatctggc  gactacttt  cctttcctt  tggcacatg  gtgatgttt  3060
ctcttggtt  tattaattt  tatgtattt  ttaatttaa  gtgaatatc  ttagaaaat  3120
tgtcttgtc  tccaaatgc  agttgattg  ttgtccaca  tcaaccaaa  tatcttgaa  3180
cctctactg  aacagattg  tacaaactg  ggaaaagta  taatttgta  acattggac  3240
tgttttaat  ctagaatct  atgtgccat  tgtttgttt  acacatttt  cctttgaaa  3300
agaagtaaa  aaagtataa  catatgata  tgtcttact  ctgacacag  tttcatacc  3360
cagaccctc  aagaaccaa  tcttttatt  atccaactc  tactttaaa  tgaagacta  3420
tgataatac  ccaggtttg  tttttcttt  aatctttca  atcactgaa  ctttaagta  3480
ccatgtagt  cttgaaaat  aagtctggc  acaactgta  ttcagagga  cctagtaca  3540
tacaaccca  gtgcacttt  taatgtctc  gggtcctga  gaatcaaga  acaaattaa  3600
tatgttctg  aagcagacc  ttaactata  gagccttcg  tttaactat  ttctgtaag  3660
agaccgtta  ctataggag  cttcggttt  ccctcatac  agtgtctaa  cacatctca  3720
cagttcact  tgctcttct  catccaggg  tgatgtgtt  cctctggaa  ggtacatgt  3780
ttccagggt  ttttgaact  gcaggtatc  attttttta  gccaatctg  tctaataac  3840
ctggcttct  caaagccac  gcatttcta  tccagctgt  ccgaagctt  agactaaaa  3900
agctgcatt  aaagaagag  cactccctt  acccccccc  cccacctaa  ggtgtttac  3960
ttatcttgt  ggattaact  atttagaga  gctataatt  aaaataggc  gtatttaag  4020
tagcgtcag  tagcattta  gaaaatcat  ttttctaaa  tccatactt  ttgaaaaga  4080
atctggtct  gttagaaaa  aaatttcta  tttgtcctc  atttagttt  agttttact  4140
ggttgatag  tatctcgat  acaaaggcc  tagacagct  cccccattt  ttcattgag  4200
tttgcatgg  catcacaca  gttagttgg  tttaggtca  gggctgacc  tacttctag  4260
tcttttgct  gtaagttca  gttagaatt  gtgacagaa  cataggaat  ttcagagat  4320
ctctattaa  atttcttaa  actgcagac  ctgcttttg  ttttgtact  gttaaaact  4380
tacattcag  ttgctatgt  cctattttc  ataatagtt  gtctatttt  ca  4432



<210> 1866
<211> 899
<212> PRT
<213> Rattus norvegicus
<308> P33568
<400> 1866

Pro Glu Asp Asp Pro Ala Gln Asp Ser Asp Pro Glu Glu Leu Pro Leu 
  1               5                  10                  15
Ile Arg Leu Glu Phe Glu Lys Ile Glu Glu Pro Glu Phe Ile Ala Leu 
             20                  25                  30
Cys Gln Lys Leu Lys Val Pro Asp His Val Arg Glu Arg Ala Trp Leu 
         35                  40                  45
Thr Trp Glu Lys Val Ser Ser Val Asp Gly Ile Leu Glu Gly Tyr Ile 
     50                  55                  60
Gln Lys Lys Lys Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val 
 65                  70                  75                  80
Asp Leu Asp Glu Met Pro Phe Thr Phe Thr Glu Leu Gln Lys Ser Ile 
                 85                  90                  95
Glu Thr Ser Val Tyr Lys Phe Phe Asp Leu Leu Lys Glu Ile Asp Thr 
             100                105                110
Ser Thr Lys Val Asp Asn Ala Val Ser Arg Leu Leu Lys Lys Tyr Asn 
         115                120                125
Val Leu Cys Ala Leu Tyr Ser Lys Leu Glu Arg Thr Cys Gly Leu Ile 
     130                135                140
Tyr Leu Thr Gln Pro Ser Ser Gly Leu Ser Thr Glu Ile Asn Ser Met 
 145                150                155                160
Leu Val Leu Lys Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu 
                 165                170                175
Val Val Gln Met Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu 
             180                185                190
Cys Val Leu Asp Tyr Phe Ile Lys Leu Ser Pro Pro Ala Leu Leu Arg 
         195                200                205
Glu Pro Tyr Lys Thr Ala Ala Thr Pro Ile Asn Gly Ser Pro Arg Thr 
     210                215                220
Pro Arg Arg Gly Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu 
 225                230                235                240
Ser Asp Thr Arg Thr Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn 
                 245                250                255
Val Asp Glu Val Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Ile 
             260                265                270
Ser Ser Leu Gly Ile Val Ser Ser Asn Gly Leu Pro Glu Leu Glu Ser 
         275                280                285
Leu Ser Lys Arg Tyr Glu Glu Val Tyr Leu Lys Ser Lys Asp Leu Asp 
     290                295                300
Ala Arg Leu Phe Leu Asp His Asp Lys Thr Leu Gln Thr Asp Thr Ile 
 305                310                315                320
Asp Ser Phe Glu Thr Glu Arg Thr Pro Arg Lys Ser Asn Pro Asp Glu 
                 325                330                335
Glu Ala Asn Met Val Thr Pro His Thr Pro Val Arg Thr Val Met Asn 
             340                345                350
Thr Ile Gln Gln Leu Met Val Ile Leu Asn Ser Ala Ser Asp Gln Pro 
         355                360                365
Ser Glu Asn Leu Ile Ser Tyr Phe Ser Asn Cys Thr Val Asn Pro Lys 
     370                375                380
Glu Asn Ile Leu Lys Arg Val Lys Asp Val Gly His Ile Phe Lys Glu 
 385                390                395                400
Lys Phe Ala Ser Ala Val Gly Gln Gly Cys Ile Asp Ile Gly Ala Gln 
                 405                410                415
Arg Tyr Lys Leu Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met 
             420                425                430
Leu Lys Ser Glu Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu 
         435                440                445
Leu Asn Asp Asn Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu 
     450                455                460
Val Val Met Ala Thr Tyr Ser Arg Ser Met Leu Gln Asn Leu Asp Ser 
 465                470                475                480
Gly Thr Asp Leu Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys 
                 485                490                495
Ala Phe Asp Phe Tyr Lys Val Ile Glu Ser Phe Ile Lys Val Glu Ala 
             500                505                510
Asn Leu Thr Arg Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg 
         515                520                525
Ile Met Glu Ser Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu 
     530                535                540
Ile Lys Gln Ser Lys Asp Gly Glu Gly Pro Asp His Leu Glu Ser Ala 
 545                550                555                560
Cys Ser Leu Ser Leu Pro Leu Gln Ser Asn His Thr Ala Ala Asp Met 
                 565                570                575
Tyr Leu Ser Pro Ile Arg Ser Pro Lys Lys Arg Thr Ser Thr Thr Arg 
             580                585                590
Val Asn Ser Ala Ala Asn Thr Glu Thr Gln Ala Ala Ser Ala Phe His 
         595                600                605
Thr Gln Lys Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys 
     610                615                620
Val Tyr Arg Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Ala Arg Leu 
 625                630                635                640
Leu Ser Asp His Pro Glu Pro Glu His Ile Ile Trp Thr Leu Phe Gln 
                 645                650                655
His Thr Leu Glu Asn Glu Tyr Glu Leu Met Lys Asp Arg His Leu Asp 
             660                665                670
Gln Ile Met Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile 
         675                680                685
Asp Leu Lys Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His 
     690                695                700
Ala Ala Gln Glu Thr Phe Lys Arg Val Leu Ile Arg Glu Glu Glu Phe 
 705                710                715                720
Asp Ser Ile Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys 
                 725                730                735
Thr Asn Ile Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro 
             740                745                750
Ile Pro His Ile Pro Arg Ser Pro Tyr Lys Phe Ser Ser Ser Pro Leu 
         755                760                765
Arg Ile Pro Gly Gly Asn Ile Tyr Met Ser Pro Leu Lys Ser Pro Tyr 
     770                775                780
Lys Ile Ser Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser 
 785                790                795                800
Arg Ile Leu Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe 
                 805                810                815
Gln Lys Ile Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg 
             820                825                830
Ser Ala Glu Gly Gly Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe 
         835                840                845
Asp Ile Glu Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Ala 
     850                855                860
Glu Ser Lys Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr 
 865                870                875                880
Arg Met Gln Lys Gln Lys Leu Asn Asp Ser Met Glu Ile Ser Asn Lys 
                 885                890                895
Glu Glu Lys 
             900



<210> 1867
<211> 4839
<212> DNA
<213> Homo sapiens
<308> L41870
<400> 1867

tccggtttt  ctcagggga  gttgaaatt  tttttgtaa  gggagtcgg  agaggacgg  60
gcgtgcccc  cgtgcgcgc  cgtcgtcct  cccggcgct  ctccacagc  cgctggctc  120
cgccgcgga  aggcgtcat  ccgcccaaa  ccccccgaa  aacggccgc  accgccgcc  180
ctgccgccg  ggaaccccc  gcaccgccg  cgccgcccc  tcctgagga  gacccagag  240
aggacagcg  cccggagga  ctgcctctc  tcaggcttg  gtttgaaga  acagaagaa  300
ctgatttta  tgcattatg  cagaaatta  agataccag  tcatgtcag  gagagagct  360
ggttaactt  ggagaaagt  tcatctgtg  atggagtat  gggaggtta  attcaaaag  420
aaaaggaac  gtggggaat  tgtatcttt  ttgcagcag  tgacctaga  gagatgtcg  480
tcactttta  tgagctaca  aaaaacata  aaatcagtg  ccataaatt  tttaactta  540
taaaagaaa  tgataccag  accaaagtt  ataatgcta  gtcaagact  ttgaagaag  600
atgatgtat  gtttgcact  ttcagcaaa  tggaaagga  atgtgaact  atatatttg  660
cacaaccca  cagttcgat  tctactgaa  taaattctg  attggtgct  aaagtttct  720
ggatcacat  tttattagc  aaaggggaa  tattacaaa  ggaagatga  ctggtgatt  780
catttcagt  aatgctatg  gtccttgac  attttatta  actctcacc  cccatgttg  840
tcaaagaac  atataaaac  gctgttata  ccattaatg  ttcacctcg  acacccagg  900
gaggtcaga  caggagtgc  cggatagca  aacaactag  aaatgatac  agaattatt  960
aagttctct  taaagaaca  gaatgtaat  tagatgagg  gaaaaatgt  tatttcaaa  1020
attttatac  ttttatgaa  tctcttgga  ttgtaacat  taatggact  ccagaggtt  1080
aaaatcttt  taaacgata  gaagaaatt  atcttaaaa  taaagatct  gatgcaaga  1140
tatttttgg  tcatgataa  actcttcag  ctgattcta  agacagttt  gaaacacag  1200
gaacaccac  aaaaagtaa  cttgatgaa  aggtgaatg  aattcctcc  cacactcca  1260
ttaggactg  tatgaacac  atccaacaa  taatgatga  tttaaattc  gcaagtgat  1320
aaccttcag  aaatctgat  tcctatttt  acaactgca  agtgaatcc  aaagaaagt  1380
tactgaaaa  agtgaagga  ataggatac  tctttaaag  gaaatttgc  aaagctgtg  1440
gacagggtt  tgtcgaaat  ggatcacag  gatacaaac  tggagttcg  ttgtattac  1500
gagtaatgg  atccatgct  aaatcagaa  aagaacgat  atccattca  aattttagc  1560
aacttctga  tgacaacat  tttcatatg  ctttattgg  gtgcgctct  gaggttgta  1620
tggccacat  tagcagaag  acatctcag  atcttgatt  tggaacaga  ttgtctttc  1680
catggattc  gaatgtgct  aatttaaaa  cctttgatt  ttacaaagt  atcgaaagt  1740
ttatcaaag  agaaggcaa  ttgacaaga  aaatgataa  acatttaga  cgatgtgaa  1800
atcgaatca  ggaatccct  gcatggctc  cagattcac  tttatttga  cttattaaa  1860
aatcaaagg  ccgagaagg  ccaactgat  accttgaat  tgcttgtcc  cttaatctt  1920
ctctccaga  taatcacac  gcagcagat  tgtatcttt  tcctgtaag  tctccaaag  1980
aaaaaggtt  aactacgcg  gtaaattct  ctgcaaatg  agagacaca  gcaacctca  2040
ccttccaga  ccagaagcc  ttgaaatct  cctctcttt  actgtttta  aaaaaagtg  2100
atcggctag  ctatctccg  ctaaataca  tttgtgaac  ccttctgtc  gagcaccca  2160
aattagaac  tatcatctg  acccttttc  agcacaccc  gcagaatga  tatgaactc  2220
tgagagaca  gcatttgga  caaattatg  tgtgttcca  gtatggcat  tgcaaagtg  2280
agaatatag  ccttaaatt  aaaatcatt  taacagcat  caaggatct  cctcatgct  2340
ttcaggaga  attcaaacg  gttttgatc  aagaagagg  gtatgattc  attatagta  2400
tctataact  ggtcttcat  cagagactg  aaacaaata  tttgcagta  gcttccacc  2460
ggcccccta  cttgtcacc  atacctcac  ttcctcgaa  cccttacaa  tttcctagt  2520
cacccttac  gattcctgg  gggaacatc  atatttcac  cctgaagag  ccatataaa  2580
tttcagaag  tctgccaac  ccaacaaaa  tgactccaa  atcaagaat  ttagtatca  2640
ttggtgaat  attcgggac  tctgagaag  tccagaaaa  aaatcagat  gtatgtaac  2700
gcgaccgtg  gctcaaaag  agtgctgaa  gaagcaacc  tcctaaacc  ctgaaaaaa  2760
tacgctttg  tattgaagg  tcagatgaa  cagatggaa  taaacatct  ccaggagag  2820
ccaaatttc  gcagaaact  gcagaaatg  cttctactc  aacacgaat  caaaagcag  2880
aaatgaatg  tagcatgga  acctcaaac  aggaagaga  atgaggatc  caggacctt  2940
gtggacact  tgtacacct  tggattcat  gtctctcac  gatgtgact  tataacttt  3000
ccaggttct  tttatggcc  catttaata  cttcagctc  ttttgtgga  ataaaatgt  3060
cagatgcaa  tgtttgggt  attcctaag  cacttgaaa  gttagtcat  gttatttat  3120
caagattga  aatcttgtg  aaatcctgc  atttaaaaa  ttgtagcag  ttgtttcct  3180
ttccaaagt  aaattgctg  gctttatgg  tagtaagaa  ggccctaga  tgggagtcc  3240
gataaccca  gcctgtctg  ctactttgc  ttcttttgt  gcatatagg  gatgtttgc  3300
cttgttttt  ttaatttat  tgtatattt  tttaattta  catgaacac  cttagaaaa  3360
gtgtcctat  tatcttcca  atgcaattt  attgactgc  cattcacca  aattatcct  3420
aactcttct  caaaaatgg  tattattag  aattagaaa  aaattacta  ttttacaca  3480
tagatttta  tttactatt  gaatctgat  tactgtgtg  ttgttttat  aaattttgc  3540
tttaattaa  taaaagctg  aagcaaagt  taaccatat  atactatca  actactgaa  3600
cagatttca  acctcagaa  gtaaaagaa  ttactgatt  ttttcttca  ccaacttat  3660
tttttaaat  aggattatt  atagtactc  tggttttta  accattcag  tcactgaat  3720
tataaagta  ccatctagt  cttgaaaaa  taaagtgtt  tgccagatc  taggtatag  3780
ggaccctaa  acagtatat  ccaagtgca  tttctaatg  ttctgggtc  tgaagaatt  3840
agatacaaa  taattttac  ccataaaca  actgttaat  ataggagcc  taatttttt  3900
ttcatagag  tttgtctaa  tgcatctca  aattattct  ccctcctta  tttgggaag  3960
tttgtgttt  ctctggaat  gtacatgtc  tccatgtat  ttttgaact  gcaattgtc  4020
atttatctt  tattttttt  agtcagtat  gtctaacac  ggcatgttc  aagccacat  4080
atttctagt  caaaattac  agtaatcaa  ggtcattat  ggttaggca  taatgtttc  4140
atctgattt  gtgcaaaag  ttcaaatta  aacagctgc  ttagaaaaa  aggcgcttc  4200
cccctcccc  acacctaaa  gtgtattta  actatcttg  gtgattaac  tatttagag  4260
tgctgtaac  taaaatagg  gatatttaa  gtagcttca  ctagctttt  ggaaaatca  4320
tttgtctaa  tcagaatta  ttttaaaaa  aaatctggt  ttgttagaa  acaaaattt  4380
attttgtgc  catttaagt  tcaaactta  tattttgac  gttattttg  taacaatga  4440
actagaaaa  ttgactcca  ttcatcatt  tttctgcat  aatatcata  aaatcagtt  4500
gtttttagg  caagggctt  ctatttctg  gtcttttgc  actaagttc  cattagaat  4560
agtgccaga  ttttaggaa  ttcagagat  gtgtattga  atttcttaa  taatgcttc  4620
gatattatt  ctttattgc  tttttgtat  ggttaaaac  gtacattta  aattgctat  4680
ttactattt  ctacaatta  tagtttgtc  attttaaaa  aaattagtt  ttaagagtc  4740
taatggtct  atgttgtgt  ctttgtatt  agtacacta  tgttctctt  tctgtctag  4800
agaagatag  tagaagata  ctctcctag  atctcatcc  4839



<210> 1868
<211> 928
<212> PRT
<213> Homo sapiens
<308> P06400
<400> 1868

Met Pro Pro Lys Thr Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala 
  1               5                  10                  15
Ala Ala Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp 
             20                  25                  30
Pro Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu 
         35                  40                  45
Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu 
     50                  55                  60
Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys 
 65                  70                  75                  80
Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys Lys Lys 
                 85                  90                  95
Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val Asp Leu Asp Glu 
             100                105                110
Met Ser Phe Thr Phe Thr Glu Leu Gln Lys Asn Ile Glu Ile Ser Val 
         115                120                125
His Lys Phe Phe Asn Leu Leu Lys Glu Ile Asp Thr Ser Thr Lys Val 
     130                135                140
Asp Asn Ala Met Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala 
 145                150                155                160
Leu Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln 
                 165                170                175
Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys 
             180                185                190
Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met 
         195                200                205
Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val Leu Asp 
     210                215                220
Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys Glu Pro Tyr Lys 
 225                230                235                240
Thr Ala Val Ile Pro Ile Asn Gly Ser Pro Arg Thr Pro Arg Arg Gly 
                 245                250                255
Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg 
             260                265                270
Ile Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val 
         275                280                285
Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly 
     290                295                300
Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg 
 305                310                315                320
Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe 
                 325                330                335
Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp Ser Phe Glu 
             340                345                350
Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp Glu Glu Val Asn Val 
         355                360                365
Ile Pro Pro His Thr Pro Val Arg Thr Val Met Asn Thr Ile Gln Gln 
     370                375                380
Leu Met Met Ile Leu Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu 
 385                390                395                400
Ile Ser Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu 
                 405                410                415
Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys 
             420                425                430
Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu 
         435                440                445
Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser Glu 
     450                455                460
Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn 
 465                470                475                480
Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu Val Val Met Ala 
                 485                490                495
Thr Tyr Ser Arg Ser Thr Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu 
             500                505                510
Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe 
         515                520                525
Tyr Lys Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg 
     530                535                540
Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser 
 545                550                555                560
Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser 
                 565                570                575
Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys Pro Leu 
             580                585                590
Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp Met Tyr Leu Ser 
         595                600                605
Pro Val Arg Ser Pro Lys Lys Lys Gly Ser Thr Thr Arg Val Asn Ser 
     610                615                620
Thr Ala Asn Ala Glu Thr Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys 
 625                630                635                640
Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg 
                 645                650                655
Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu 
             660                665                670
His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu 
         675                680                685
Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met 
     690                695                700
Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp Leu Lys 
 705                710                715                720
Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His Ala Val Gln 
                 725                730                735
Glu Thr Phe Lys Arg Val Leu Ile Lys Glu Glu Glu Tyr Asp Ser Ile 
             740                745                750
Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile 
         755                760                765
Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His 
     770                775                780
Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro 
 785                790                795                800
Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile Ser 
                 805                810                815
Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser Arg Ile Leu 
             820                825                830
Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys Ile 
         835                840                845
Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala Glu 
     850                855                860
Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe Asp Ile Glu 
 865                870                875                880
Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys 
                 885                890                895
Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln 
             900                905                910
Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys 
         915                920                925



<210> 1869
<211> 10170
<212> DNA
<213> Rattus norvegicus
<308> D25543
<400> 1869

ggcgcgtcg  tggtggcgc  gcgcttggg  tacccgagc  gacgtggct  agattgggc  60
gggggcgtc  ggagttgtc  gggacggcc  cctacagtg  ttgaagagg  cagaaaagg  120
catcagatc  tctaggact  gagttacgg  cagttgtga  cagccacgt  gatactgag  180
ggcgaaccc  aggccctct  gaagagcag  tggtgctct  aacctctga  caactctgc  240
gaccccact  tgagtcatt  ttctccgtg  ccatggagc  ctccttcag  gatgctgag  300
cgattatcg  gattagcaa  taatgtttt  catgaatta  caggagatt  cactggctg  360
actacaatg  cttcctcgg  agctgaatt  ccccagggt  ctgccatgg  attgaataa  420
agtacccaa  aggacgttc  ggatcgcct  gctgatgca  agaagttag  gctggagct  480
aaggatatc  tcagtaagc  ggatgctca  ctccagcaa  aggacgaag  tctgcagga  540
gaaaaaaaa  gagctgaaa  caaaattaa  aaaataaaa  ttcatgcaa  ggccaagat  600
acgtccttg  acaaacaaa  agaagaatt  aagacacaa  gaggagctg  ctcgcctcc  660
gaagtgcag  cagaggagc  ctccaagca  gataagagt  caacagaag  ggagatgga  720
gtagaaaaa  taaaacatg  actccagga  aaggagaaa  taattagca  tttgcaagc  780
cagctggac  aggcgcagt  agaacaagc  tcccagttg  ataagagtt  tgcggagat  840
gaggacttc  tcctgatga  gcagaagct  caagagaag  aggaactca  cggcgcttt  900
caaacgcag  tcagccaga  acaggcaga  caagctgcc  agaaattga  ggtgatgca  960
aggaagctt  aggaacacg  agaagcctt  ctgggccga  ctcaggttg  ggacctgct  1020
cagaaggag  tgacttctg  agaacagag  aaccaggat  tttcacagc  gttgcagct  1080
ttggaggct  aacacagta  tttaaggaa  accatggaa  cagaaagac  ggagtccaa  1140
atcctgatg  aaaaggtag  actcgaaat  gcagagagg  aggaagagc  gtatcagct  1200
cagggacag  tggagcgag  aggccaagc  caggctgag  tggagatgc  gtacggtac  1260
ctccagcaa  gacatgaga  agaaatgga  gagaagaca  cttgcattt  gcttcttca  1320
aagaacgag  aggagctgc  gtctgcctg  gacgctctg  aggaggaaa  ctccaagct  1380
cttcaggag  agcaggaac  ggctgccaa  tcagcccag  ccctgcagc  gctggaaga  1440
gaactccag  aaaaatcta  agaaattag  caatttgta  acaaaccaa  cttggaaaa  1500
catgagaca  catctcaga  gtctttacc  gatgtttat  atgagggcg  acaggcagt  1560
atggaggag  gtgtcgcct  tttacagaa  agagtacta  agctagaga  tgagaaggg  1620
gccttgctc  ttagttctc  agagctgga  gagctgaga  ctgagaacg  aaaactctg  1680
tctcggatt  ctcttctgg  ggctcagaa  agagcagga  aggctgatg  tatggtctg  1740
gaggtcagc  cagctggta  tgctttgct  aacaggagc  actcttcta  tgaagaaag  1800
ggacaggat  tcctagaga  cacattttc  cagaaacat  aagagctgt  ggttttatt  1860
gtggaaatg  aggaagccc  ggaggaaat  gcatttctt  agtcgcagc  gcagggcaa  1920
aggcctgaa  gggactatg  ggtccttga  cggaaagaa  tacagatga  ggagagtga  1980
ggactgccc  cagttacag  acgagatgt  ctctgtgcg  cccgtgaca  gaacagtgt  2040
ccagcagtg  aaggggaac  ggcaggcat  agagatcag  acggaacat  ggaggcggg  2100
cctctaaat  acaccggaa  ggaactgaa  tccccacag  cggacggtg  ggacaaatc  2160
ctctctgca  cacatgtct  tctgtgtca  cagggtgaa  tggaaaggc  gaaaactca  2220
gttttggag  ttgagacaa  ccttcatac  gccaaggaa  ctcatgaga  gaatttaag  2280
gagaaagcg  aggaaatta  cagcctaac  cagcttacc  aggagttca  agagagtgc  2340
gaggaagcc  gcagcacgc  cactgctgt  tgtgaagaa  gagaccagc  gctttaccg  2400
gtgaaggag  ttgatgtcc  tggagaact  cgggctcag  tccgagaac  ggaaaccag  2460
cttgcagaa  cagagaagc  aagaggtct  gactatgaa  gtcagaggg  tcagcacaa  2520
ctgctcacc  agcagatcc  cagcctaag  atagaagcc  aatctaaag  tgtgaaaat  2580
gagacttta  aaagagagc  ggatggtgt  caactacaa  tttctgaac  gggaacaca  2640
ataaaaagc  tacagagcc  actgcagac  aaggaaagt  aagtgctag  gggggcaga  2700
cgtatgaag  acatctcaa  agaaatgga  gaactgtcg  aggcgcttt  acagaagga  2760
ctggaaata  cccaaatgg  ccaactctt  ttagagaaa  agaaagatg  ggagacact  2820
cagcaaacc  tccaggaga  ggatcagca  gtgactgaa  tcagcttca  tatgacaga  2880
aaaatggtt  agcttaatg  agagaagtt  tctcttggg  tagaaatta  gactctgaa  2940
gagcagctc  gtttattgt  cagagctga  ggagcaaag  gagagcagg  agaagacag  3000
ggagctgag  ccagcccta  acatggtcc  catgagtcg  gcgcagagg  gccagtgtg  3060
aaagaggca  tacagcaag  acttgagtg  ctgaggaaa  agagtgagc  gaggaagcg  3120
aaactgcag  cagcgctga  cagcagaaa  gagctactg  agaaagtca  caagctgga  3180
gaggagtta  ccaaggtga  agaggagtc  acaaaagac  ccctcaggg  gagtgagaa  3240
agagagctg  aggaagaca  caagaacaa  gatgaccca  aaaagtatg  gacttctga  3300
tggagagaa  tagaggttt  tttaagact  acaatatct  aaaaggaag  ggaactgga  3360
ggcataagg  gggacttaa  agaaaaggc  gcagcagaa  aagagttac  ggccttggt  3420
caacggatg  ctcaggacc  gcagaataa  acaaagcag  tagacttgc  tcaagaaga  3480
atcactgaa  accaagcaa  tattcagaa  ttcatcaca  gcaccatgg  tgctgggga  3540
ggagactca  cagtaaagg  aacctcggt  agcagccca  cccgtgcag  gggtgggga  3600
cactggaag  cggagctgg  gggaaagat  gtagacctg  aaaaagaaa  gactcaact  3660
caaaagaag  ttcaagaag  cttaatttc  cgtaaggca  ttctaaaaa  ggcacaaga  3720
aaagagaaa  atctgaagg  agagctcaa  gagcagaag  atgcttacc  tcacctaca  3780
gaacagttt  atgggcaga  taaggaaaa  gagaacatt  gggccccgc  aaggcaact  3840
caagcaaag  agtctacag  ccagcagct  ccaggcact  gccagcagg  gcccactca  3900
ggttcagaa  gcctttcac  cgaaggcac  gagcctgct  cagagtctg  cttacacgc  3960
gctcagcct  cgcaccctg  agagacagc  actctccag  ctaccgttt  tgttgccca  4020
attcaggac  agctgaaag  aattgaggt  gagaaagaa  agctggaat  gaaaattag  4080
tctacaaca  gtgagctga  caaaaaatc  gaagaagta  tactactac  agaacagat  4140
aatgaacag  gcttagaaa  ccagaattt  aaggcagcg  cccacgaag  caaggccca  4200
acagaacag  tgaagcaag  attggaaag  agccaattg  aaattgctg  cctggaaca  4260
ctgaaaaca  tacagcctg  actagaaac  ctgcaaaag  acgtgggcc  gaaggaaga  4320
gaggtcagc  accttgttg  acagcttgg  gagaaggag  agaccctca  caccgtaca  4380
acagaaatg  aggagcagg  gcgtttaat  aaggccctg  acacacagc  ggaaatgca  4440
gccaaggag  atgaggaga  gctaaagca  gtccaggtg  aaatttgtg  gctaaagaa  4500
cagccaaaa  agcttgagg  agaaagtaa  gcaaaacag  aattacaga  gaaactgca  4560
gctgccctc  tctcccgga  ggaggccct  aaggaaaac  agagtctgc  ggagcagtt  4620
tcctcggcc  gagatgctg  tgaacatct  accaaatct  tggcagatg  agagagcca  4680
gtttctgtt  agaatcaag  gaaagatgc  ctcctagga  agttagccc  tcttcagga  4740
gaaagggac  aactcattg  agaaatgga  aagtcttta  tggaaaatc  gagccttgg  4800
ggctcttgt  aaagcctga  gctagctct  gggggcctc  ctgaagaca  ggaaaagct  4860
atgaaggag  tggaatccg  gagatgttc  aagattgca  agagcaccg  atggcaaga  4920
aagcacaag  agctacaga  agagtatga  gttcttctg  agtcctacg  gaatgtgag  4980
aatgaggca  agaggattc  acacgtggt  gagagcgtg  ggcaagaga  gcaggaggt  5040
tacgcaaag  taaggagcg  agagtcaga  aagagagag  gagagaagc  gctgcagga  5100
gcagaacag  aaatggagg  gatgaagga  aagatgaga  agtttgcca  atctaagca  5160
cagaagatc  ttgagctag  ggaagaaaa  gaccgactt  gagcagagg  ccagcctgt  5220
ggaggagcc  atgaaagca  ggaagctct  ctttcttcc  atgccagct  aaaggagga  5280
ctagaaagg  tcacattgg  gtataaaac  ctttctaag  aatttgagg  tttaatggc  5340
gagaagaac  ctctgagtg  agagactcg  aatctgaag  ttcaggtag  agctcagga  5400
ctgaaacaa  ctagcctcg  gaccaccga  aagtctgat  agccaaagg  tgtcatcga  5460
gaggtaaca  aagccgtgg  aggcaagtc  caagaacaa  attccctga  tgaaaatgc  5520
aagcttgaa  atgcagaag  tactctctt  gctaacagt  ccaagcctg  tgtcagtga  5580
actttcagc  cacacgatg  catcaataa  tacctccag  agcttgatc  gcttaaagg  5640
agaattgct  agttagaga  ggagaaaca  aaagacagg  agcttagcc  gactttgga  5700
aatgaaaaa  atgccctac  gactcagat  tctgcaaag  atagtgagc  caagctcct  5760
gaggaagag  ttgccaaaa  aaacatgct  aatcagcaa  tccaagagg  gctctccag  5820
gtcaccaag  tgaaagaga  agcagagga  gagaaagat  acttagaag  gaggctgat  5880
aatcaactg  cggaactta  tgggagcat  gggaattat  accaggatg  tacagacgc  5940
caaataaag  acgagcaac  agagtcaga  atgcagaac  ttaaaagat  tgtgagtga  6000
ttagaagaa  aaaagcagc  gctggtcaa  gaaaaaacc  aggtggagt  agaaatacg  6060
aaagagtac  tggaaaaga  acaaggtgc  cagaaggga  ctggcagta  aatccacgc  6120
aaagagcta  aggagctgc  caaggaaaa  cagcaagaa  tgaagcaac  gcagaagga  6180
tgcatccgg  acctcggca  gatcagtgc  ctggagaag  ccgtcaagg  cctcgagtt  6240
gttcacact  aatcccaaa  ggatttgga  gcaaccaaa  gaaatctgg  tcaggccgt  6300
gaacaccac  agaaggcac  ggccgagtt  tccagcttc  agatactgc  agatgacac  6360
caaagcgaa  cagcaagag  gctagcgga  aacctcaag  tgaaaaagg  gcttcagtc  6420
aacaaagag  ccatcaaaa  ccagataaa  caaaaagac  aagacctct  gcgaagact  6480
gagcaagca  aagagaaac  ccgaaaaga  aagaagaac  tgcaagaga  gctggatgc  6540
ttgcacaga  aaaaagccc  tgtggaaga  acgcttgcc  agattcaag  cagtctgac  6600
aggaaagac  aggacatga  ggagctgca  caaagcctg  acagcacct  ggcccagct  6660
gcggccttc  ctaagagca  gtcgtccct  caggatgac  gggacaggg  gatcgatga  6720
gccaagaaa  gggagcaga  gttcggtga  gccattcag  ccaaagagg  ggaggtcag  6780
ctcaaagag  agaactgca  tgctctaaa  gatcagctc  gacaaatga  catccacat  6840
gaggaactg  agatcaccg  gtccaggct  gaacatgac  aggaaattt  ggagtccaa  6900
gcccagacc  agctccagc  tcaacagaa  gcttatgat  agctgcaag  agaaaataa  6960
gaacttatg  cacagttag  agaagctgg  cagctgtac  atgattcta  gaatgaatt  7020
actaagttg  aatcagaac  taagagtct  aaagaccaa  caactgact  aaagaactc  7080
ttagaaaaa  gcagagaac  cgaaaacaa  ttggaaggg  tcatcaagc  gcaagaagc  7140
gacatccag  attgtaagt  caattgtga  caactagag  ctgacctga  agcctccag  7200
gagctaacc  ctcggctgc  tgatgaaat  aatgtgaag  aacagaaga  tataagcct  7260
ctttctggc  aggaagagg  gatccaagt  gctatcgca  aactgcacc  acagcacag  7320
aaagagatc  aagaattag  aaacctgtt  tcccaggag  aagaggaga  tttgacctt  7380
gaagaggaa  acaaaaggg  tgttgagaa  accaaccag  tcacagaag  actagaaac  7440
atcaagaag  agagccttg  gcagaaggc  cagttggat  cctttgtta  gtccatgtc  7500
tctcttcag  acgaccggg  ccgcatagt  agtgactac  gacagctgg  agagcggca  7560
ctttctgtg  tcttggaaa  ggacgagct  atccaagat  ctgctgctg  gaataataa  7620
ctgaaggag  agattcgag  gctgcgagg  cacatggat  acctcaact  tgagaatgc  7680
aagctggat  ctgaactga  ccagtatag  cgggacctg  atgaagtga  caccataaa  7740
gactcgcag  aaaggcagc  ccttgaggc  cagctgcag  agaacaaag  gctgagaaa  7800
gagtgtgta  agctagaag  aaggctgaa  gggtcagag  cagagaagc  gagcctgca  7860
atgtccttg  acgccctcc  ggaggagaa  caaggtttg  ctaaagaga  caaaagctt  7920
aaggagcag  tgacggcct  gcacgagga  ggtgcccta  ctgtctacc  tgcccaact  7980
agagtaaga  aggaagaag  tcagaagtt  actgcggct  tctcctcct  tcagaagag  8040
actgtggat  tgcaagagg  gttggtttg  gtccagaag  aggcaagca  gaaggtgag  8100
gagattgaa  ataagctga  gagggagct  aagcatctc  atcacaacg  agggataat  8160
cggaacgaa  cagagacag  agaagagag  gtggcagag  tggccagag  cctcgtcga  8220
atggaacag  agttgctta  ggtaaccaa  gagaataag  atcttacgg  acagattca  8280
gccttcgga  agtcgatga  ttccttgca  gacagcaga  atcatgcca  tgaggagct  8340
agtgacctg  agaagaagt  tgatgccag  ctgaaagag  tggctcagc  gaaagggcg  8400
caggactta  gcagagaga  tgacgttct  tcccaggct  cctttcccc  gaccacctc  8460
gaaaacatc  cgtcccgcc  tgagaaact  aaccagcag  tcatatcca  agacgagca  8520
ttgcttcac  tatcttcag  actagaaag  tctcacaac  aagtgcagt  cttcaccaa  8580
gccatgacc  gcctacaga  tgagagaga  cacctgtgg  atgagctgg  gaaattccg  8640
aagtcggag  aagggaagc  gaggtctgc  gccccttca  ctgcctcca  cccagcaga  8700
gtacagagc  tgaaaaaag  catgtcttc  ctccagaat  acagagatc  attgctgaa  8760
gaactgaag  atctacaac  gcagtactt  cagatgaac  aagagatca  cgagctccg  8820
ccgctgaag  ctcagcttc  ggaatctca  gatcagacc  aagccctgc  gatgatgaa  8880
gaggagctc  ggcaggaaa  cctctcctg  cagcacgag  tcgatcagc  cagagtgga  8940
aagaactct  gggagctgc  tgagagaag  atgaaggaa  agtacctta  ggccatctc  9000
gataaagat  agcagcttg  ccacctgca  aatctcctg  gggaactga  gtcttcctc  9060
cagactcag  ttctcccca  acagtacca  cgacaggcg  cctcaggga  atcagctgc  9120
ctcgacggg  cacaaaacc  agtttatga  acagactgt  tcaggaccc  gctcaatga  9180
agcttaaag  aaatccatc  gaaggagct  agaattcag  aactgaaca  caagttctc  9240
cagctgctt  aggagaaga  catcctctc  acccagctc  gggacgcca  ccagagtct  9300
cgtgacagc  agcatcact  cagtaacct  ttcaaccac  gtgccatcc  ggagaggca  9360
gtgcagcag  tgcaggcta  ggggccact  aatgcagat  ttgctccag  agcacccca  9420
gaaaaggat  ggattcaca  aaagactga  actgagacc  caggggagg  acagccaag  9480
ttttctgaa  tccagcagc  gctgtgcaa  actaaacac  atctgagcg  gctaaagaa  9540
ctgctggaa  aagagcgag  ccaaagact  accgccgaa  atgcactct  cctggccaa  9600
gagcagatc  gacggttgg  gcatagcga  tgggagtca  cccggaccc  aatcattgg  9660
gcctgtggc  ctcaggagc  ggtgctgtt  atggatctc  caggcagta  ctgtcggag  9720
acccggagc  gtgctggat  gaagcgggt  ctgcgttct  tctgccgtt  ccggacccg  9780
gtgccactg  tcgcagcca  ctacttcct  atgattcat  ttttactgg  tctgtgttt  9840
acgggtcac  tataaactt  ttacttgac  actctcgca  ttgtaattc  ttatctgta  9900
tgtcaggat  gttgatccc  gggcggcct  tcgctttga  cccaccctc  tggaaagtg  9960
ctgtgaaaa  aggtggctg  gaggacagg  ggcggtaag  tggcctgcc  catccgctc  10020
ccttaaaca  gtcggcttc  gagatgtgc  gtgttcact  cttcttcag  tgatgcaga  10080
ccacatccc  tgtggcctt  caggatgct  agagaggct  tctagccgt  ccaacaaga  10140
ggttccaat  aacacagta  tctggaatcc  10170



<210> 1870
<211> 3187
<212> PRT
<213> Rattus norvegicus
<308> BAA05026
<400> 1870

Met Leu Ser Arg Leu Ser Gly Leu Ala Asn Asn Val Leu His Glu Leu 
  1               5                  10                  15
Ser Gly Asp Tyr Thr Gly Trp Thr Thr Met Thr Ser Ser Glu Ala Glu 
             20                  25                  30
Leu Pro Gln Gly Ser Ala Met Glu Leu Asn Asn Ser Thr Gln Lys Asp 
         35                  40                  45
Val Leu Asp Arg Leu Ala Asp Ala Glu Lys Leu Val Leu Glu Leu Lys 
     50                  55                  60
Asp Ile Ile Ser Lys Gln Asp Ala Gln Leu Gln Gln Lys Asp Glu Ala 
 65                  70                  75                  80
Leu Gln Glu Glu Lys Lys Gly Ala Glu Ser Lys Ile Lys Lys Ile Lys 
                 85                  90                  95
Leu His Ala Lys Ala Lys Ile Thr Ser Leu Asn Lys Gln Ile Glu Glu 
             100                105                110
Leu Lys Thr Gln Gly Gly Ala Ala Ser Pro Pro Glu Val Gln Ala Glu 
         115                120                125
Glu Leu Ser Lys His Asp Lys Ser Ser Thr Glu Glu Glu Met Glu Val 
     130                135                140
Glu Lys Ile Lys His Glu Leu Gln Glu Lys Glu Lys Leu Ile Ser Asn 
 145                150                155                160
Leu Gln Ala Gln Leu Asp Gln Ala Gln Ser Glu Gln Ala Ser Gln Leu 
                 165                170                175
Asp Lys Ser Ser Ala Glu Met Glu Asp Phe Ile Leu Met Arg Gln Lys 
             180                185                190
Leu Gln Glu Lys Glu Glu Leu Ile Gly Ala Leu Gln Thr Gln Leu Ser 
         195                200                205
Gln Thr Gln Ala Glu Gln Ala Ala Gln Lys Leu Arg Val Met Gln Arg 
     210                215                220
Lys Leu Glu Glu His Glu Glu Ala Leu Leu Gly Arg Ala Gln Val Val 
 225                230                235                240
Asp Leu Leu Gln Lys Glu Leu Thr Ser Ala Glu Gln Arg Asn Gln Asp 
                 245                250                255
Leu Ser Gln Gln Leu Gln Leu Leu Glu Ala Glu His Ser Thr Leu Arg 
             260                265                270
Asn Thr Met Glu Ala Glu Arg Gln Glu Ser Lys Ile Leu Met Glu Lys 
         275                280                285
Val Glu Leu Glu Met Ala Glu Arg Lys Glu Glu Leu Tyr Gln Leu Gln 
     290                295                300
Gly Gln Leu Glu Arg Ala Gly Gln Ala Gln Ala Glu Leu Glu Met Gln 
 305                310                315                320
Tyr Gly Thr Leu Gln Gln Arg His Glu Thr Glu Met Glu Glu Lys Thr 
                 325                330                335
Ala Cys Ile Ser Leu Leu Gln Lys Asn Glu Gln Glu Leu Gln Ser Ala 
             340                345                350
Cys Asp Ala Leu Lys Glu Glu Asn Ser Lys Leu Leu Gln Glu Gln Gln 
         355                360                365
Glu Gln Ala Ala Lys Ser Ala Gln Ala Leu Gln Gln Leu Glu Asp Glu 
     370                375                380
Leu Gln Gln Lys Ser Lys Glu Ile Ser Gln Phe Val Asn Lys Pro Asn 
 385                390                395                400
Leu Glu Lys His Glu Thr Ser Ser Gln Thr Ser Leu Pro Asp Val Tyr 
                 405                410                415
Asn Glu Gly Val Gln Ala Val Met Glu Glu Ser Val Ala Ser Leu Gln 
             420                425                430
Lys Arg Val Leu Glu Leu Glu Asn Glu Lys Gly Ala Leu Leu Leu Ser 
         435                440                445
Ser Leu Glu Leu Glu Glu Leu Arg Ala Glu Asn Glu Lys Leu Cys Ser 
     450                455                460
Arg Ile Thr Leu Leu Glu Ala Gln Asn Arg Ala Gly Glu Ala Asp Gly 
 465                470                475                480
Met Val Cys Glu Val Ser Thr Ala Gly Ile Ala Leu Leu Asn Arg Ser 
                 485                490                495
Asp Ser Ser Thr Glu Glu Ser Gly Gln Asp Val Leu Glu Asn Thr Phe 
             500                505                510
Ser Gln Lys His Lys Glu Leu Ser Val Leu Leu Val Glu Met Lys Glu 
         515                520                525
Ala Gln Glu Glu Ile Ala Phe Leu Lys Ser Gln Leu Gln Gly Lys Arg 
     530                535                540
Pro Glu Gly Asp Tyr Glu Val Leu Asp Arg Lys Glu Val Gln Met Met 
 545                550                555                560
Glu Ser Glu Gly Leu Pro Ser Val Thr Ala Arg Asp Val Leu Cys Ala 
                 565                570                575
Pro Arg Asp Lys Asn Ser Val Pro Ala Val Glu Gly Glu Gln Ala Gly 
             580                585                590
Met Arg Asp Gln His Gly Thr Leu Glu Ala Gly Pro Leu Asn Asp Thr 
         595                600                605
Gly Met Glu Leu Asn Ser Pro Gln Pro Asp Gly Val Asp Lys Ser Leu 
     610                615                620
Ser Ala Pro His Val Cys Leu Cys His Gln Gly Glu Leu Glu Arg Leu 
 625                630                635                640
Lys Thr Gln Val Leu Glu Leu Glu Thr Ser Leu His Thr Ala Lys Glu 
                 645                650                655
Thr His Glu Lys Asn Leu Ser Glu Lys Ala Lys Glu Ile Ser Ser Leu 
             660                665                670
Thr Gln Leu Thr Lys Glu Phe Lys Glu Ser Ala Glu Glu Ala Arg Ser 
         675                680                685
Thr Leu Thr Ala Val Cys Glu Glu Arg Asp Gln Leu Leu Tyr Arg Val 
     690                695                700
Lys Glu Leu Asp Val Leu Gly Glu Leu Arg Ala Gln Val Arg Glu Leu 
 705                710                715                720
Glu Thr Ser Leu Ala Glu Ala Glu Lys Gln Arg Gly Leu Asp Tyr Glu 
                 725                730                735
Ser Gln Arg Ala Gln His Asn Leu Leu Thr Glu Gln Ile His Ser Leu 
             740                745                750
Ser Ile Glu Ala Lys Ser Lys Asp Val Lys Ile Glu Thr Leu Gln Arg 
         755                760                765
Glu Leu Asp Gly Val Gln Leu Gln Phe Ser Glu Gln Gly Thr Gln Ile 
     770                775                780
Lys Ser Leu Gln Ser Gln Leu Gln Thr Lys Glu Ser Glu Val Leu Glu 
 785                790                795                800
Gly Ala Glu Arg Met Lys Asp Ile Ser Lys Glu Met Glu Glu Leu Ser 
                 805                810                815
Gln Ala Leu Ser Gln Lys Glu Leu Glu Ile Ala Gln Met Asp Gln Leu 
             820                825                830
Leu Leu Glu Lys Lys Lys Asp Val Glu Thr Leu Gln Gln Thr Ile Gln 
         835                840                845
Glu Lys Asp Gln Gln Val Thr Glu Leu Ser Phe Ser Met Thr Glu Lys 
     850                855                860
Met Val Gln Leu Asn Glu Glu Lys Phe Ser Leu Gly Val Glu Ile Lys 
 865                870                875                880
Thr Leu Lys Glu Gln Leu Ser Leu Leu Ser Arg Ala Glu Gly Ala Lys 
                 885                890                895
Arg Glu Gln Val Glu Asp Ser Gly Ala Glu Ser Ser Pro Lys His Gly 
             900                905                910
Pro His Glu Ser Ser Ala Glu Glu Pro Val Cys Lys Glu Ala Leu Gln 
         915                920                925
Gln Glu Leu Glu Trp Leu Arg Lys Glu Ser Glu Gln Arg Lys Arg Lys 
     930                935                940
Leu Gln Ala Ala Leu Ile Ser Arg Lys Glu Leu Leu Gln Lys Val Ser 
 945                950                955                960
Lys Leu Glu Glu Glu Leu Ala Lys Val Arg Glu Glu Ser Thr Lys Asp 
                 965                970                975
Ser Leu Arg Glu Ser Glu Lys Arg Glu Leu Glu Glu Asp Ser Lys Asn 
             980                985                990
Lys Asp Asp Pro Glu Lys Tyr Gly Thr Ser Glu Trp Arg Glu Leu Glu 
         995                1000                1005
Val Ser Leu Arg Leu Thr Ile Ser Glu Lys Glu Val Glu Leu Glu Gly 
     1010                1015                1020
Ile Arg Arg Asp Leu Lys Glu Lys Ala Ala Ala Glu Glu Glu Leu Gln 
 1025                1030                1035                1040
Ala Leu Val Gln Arg Met Thr Gln Asp Leu Gln Asn Lys Thr Lys Gln 
                 1045                1050                1055
Ile Asp Leu Leu Gln Glu Glu Ile Thr Glu Asn Gln Ala Thr Ile Gln 
             1060                1065                1070
Lys Phe Ile Thr Gly Thr Met Asp Ala Gly Asp Gly Asp Ser Ala Val 
         1075                1080                1085
Lys Glu Thr Ser Val Ser Ser Pro Pro Arg Ala Gly Gly Gly Glu His 
     1090                1095                1100
Trp Lys Pro Glu Leu Glu Gly Lys Ile Val Asp Leu Glu Lys Glu Lys 
 1105                1110                1115                1120
Thr Gln Leu Gln Lys Lys Leu Gln Glu Ala Leu Ile Ser Arg Lys Ala 
                 1125                1130                1135
Ile Leu Lys Lys Ala Gln Glu Lys Glu Lys His Leu Lys Glu Glu Leu 
             1140                1145                1150
Lys Glu Gln Lys Asp Ala Tyr Arg His Leu Gln Glu Gln Phe Asp Gly 
         1155                1160                1165
Gln Ser Lys Glu Asn Glu Asn Ile Arg Ala Pro Leu Arg Gln Leu Gln 
     1170                1175                1180
Ala Lys Glu Ser Thr Asp Gln Gln Leu Pro Gly Thr Gly Gln Gln Glu 
 1185                1190                1195                1200
Pro Thr His Gly Ser Glu Gly Leu Ser Leu Glu Gly Thr Glu Pro Ala 
                 1205                1210                1215
Ser Glu Ser Asp Leu His Ala Ala Gln Pro Ser His Pro Gly Glu Thr 
             1220                1225                1230
Ala Thr Leu Gln Ala Thr Val Ser Val Ala Gln Ile Gln Asp Gln Leu 
         1235                1240                1245
Lys Glu Ile Glu Val Glu Lys Glu Glu Leu Glu Leu Lys Ile Ser Ser 
     1250                1255                1260
Thr Thr Ser Glu Leu Thr Lys Lys Ser Glu Glu Val Leu Leu Leu Gln 
 1265                1270                1275                1280
Glu Gln Ile Asn Glu Gln Gly Leu Glu Ile Gln Asn Leu Lys Ala Ala 
                 1285                1290                1295
Ser His Glu Ala Lys Ala His Thr Glu Gln Leu Lys Gln Glu Leu Glu 
             1300                1305                1310
Ser Ser Gln Leu Lys Ile Ala Asp Leu Glu His Leu Lys Thr Leu Gln 
         1315                1320                1325
Pro Glu Leu Glu Thr Leu Gln Lys His Val Gly Gln Lys Glu Glu Glu 
     1330                1335                1340
Val Ser Tyr Leu Val Gly Gln Leu Gly Glu Lys Glu Gln Thr Leu Thr 
 1345                1350                1355                1360
Thr Val Gln Thr Glu Met Glu Glu Gln Glu Arg Leu Ile Lys Ala Leu 
                 1365                1370                1375
His Thr Gln Leu Glu Met Gln Ala Lys Glu His Glu Glu Arg Leu Lys 
             1380                1385                1390
Gln Val Gln Val Glu Ile Cys Glu Leu Lys Lys Gln Pro Lys Glu Leu 
         1395                1400                1405
Glu Glu Glu Ser Lys Ala Lys Gln Gln Leu Gln Arg Lys Leu Gln Ala 
     1410                1415                1420
Ala Leu Ile Ser Arg Lys Glu Ala Leu Lys Glu Asn Lys Ser Leu Gln 
 1425                1430                1435                1440
Glu Gln Leu Ser Ser Ala Arg Asp Ala Val Glu His Leu Thr Lys Ser 
                 1445                1450                1455
Leu Ala Asp Val Glu Ser Gln Val Ser Val Gln Asn Gln Glu Lys Asp 
             1460                1465                1470
Ala Leu Leu Gly Lys Leu Ala Leu Leu Gln Glu Glu Arg Asp Lys Leu 
         1475                1480                1485
Ile Val Glu Met Asp Lys Ser Leu Leu Glu Asn Gln Ser Leu Gly Gly 
     1490                1495                1500
Ser Cys Glu Ser Leu Lys Leu Ala Leu Gly Gly Leu Thr Glu Asp Lys 
 1505                1510                1515                1520
Glu Lys Leu Met Lys Glu Leu Glu Ser Val Arg Cys Ser Lys Ile Ala 
                 1525                1530                1535
Glu Ser Thr Glu Trp Gln Glu Lys His Lys Glu Leu Gln Lys Glu Tyr 
             1540                1545                1550
Glu Val Leu Leu Gln Ser Tyr Glu Asn Val Ser Asn Glu Ala Glu Arg 
         1555                1560                1565
Ile Gln His Val Val Glu Ser Val Arg Gln Glu Lys Gln Glu Val Tyr 
     1570                1575                1580
Ala Lys Leu Arg Ser Ala Glu Ser Asp Lys Arg Glu Arg Glu Lys Gln 
 1585                1590                1595                1600
Leu Gln Asp Ala Glu Gln Glu Met Glu Glu Met Lys Glu Lys Met Arg 
                 1605                1610                1615
Lys Phe Ala Lys Ser Lys Gln Gln Lys Ile Leu Glu Leu Glu Glu Glu 
             1620                1625                1630
Asn Asp Arg Leu Arg Ala Glu Ala Gln Pro Val Gly Gly Ala Asn Glu 
         1635                1640                1645
Ser Met Glu Ala Leu Leu Ser Ser Asn Ala Ser Leu Lys Glu Glu Leu 
     1650                1655                1660
Glu Arg Ile Thr Leu Glu Tyr Lys Thr Leu Ser Lys Glu Phe Glu Ala 
 1665                1670                1675                1680
Leu Met Ala Glu Lys Asn Thr Leu Ser Glu Glu Thr Arg Asn Leu Lys 
                 1685                1690                1695
Leu Gln Val Glu Ala Gln Glu Leu Lys Gln Ala Ser Leu Glu Thr Thr 
             1700                1705                1710
Glu Lys Ser Asp Glu Pro Lys Asp Val Ile Glu Glu Val Thr Glu Ala 
         1715                1720                1725
Val Val Gly Lys Ser Gln Glu Gln Asp Ser Leu Ser Glu Asn Ala Lys 
     1730                1735                1740
Leu Glu Asp Ala Glu Ala Thr Leu Leu Ala Asn Ser Ala Lys Pro Gly 
 1745                1750                1755                1760
Val Ser Glu Thr Phe Ser Ser His Asp Asp Ile Asn Asn Tyr Leu Gln 
                 1765                1770                1775
Gln Leu Asp Gln Leu Lys Gly Arg Ile Ala Glu Leu Glu Met Glu Lys 
             1780                1785                1790
Gln Lys Asp Arg Glu Leu Ser Gln Thr Leu Glu Asn Glu Lys Asn Ala 
         1795                1800                1805
Leu Leu Thr Gln Ile Ser Ala Lys Asp Ser Glu Leu Lys Leu Leu Glu 
     1810                1815                1820
Glu Glu Val Ala Lys Ile Asn Met Leu Asn Gln Gln Ile Gln Glu Glu 
 1825                1830                1835                1840
Leu Ser Arg Val Thr Lys Leu Lys Glu Thr Ala Glu Glu Glu Lys Asp 
                 1845                1850                1855
Asp Leu Glu Glu Arg Leu Met Asn Gln Leu Ala Glu Leu Asn Gly Ser 
             1860                1865                1870
Ile Gly Asn Tyr Tyr Gln Asp Val Thr Asp Ala Gln Ile Lys Asn Glu 
         1875                1880                1885
Gln Leu Glu Ser Glu Met Gln Asn Leu Lys Arg Cys Val Ser Glu Leu 
     1890                1895                1900
Glu Glu Glu Lys Gln Gln Leu Val Lys Glu Lys Thr Lys Val Glu Ser 
 1905                1910                1915                1920
Glu Ile Arg Lys Glu Tyr Met Glu Lys Ile Gln Gly Ala Gln Lys Gly 
                 1925                1930                1935
Pro Gly Ser Lys Ile His Ala Lys Glu Leu Gln Glu Leu Leu Lys Glu 
             1940                1945                1950
Lys Gln Gln Glu Val Lys Gln Leu Gln Lys Asp Cys Ile Arg Tyr Leu 
         1955                1960                1965
Gly Arg Ile Ser Ala Leu Glu Lys Thr Val Lys Ala Leu Glu Phe Val 
     1970                1975                1980
His Thr Glu Ser Gln Lys Asp Leu Asp Ala Thr Lys Gly Asn Leu Ala 
 1985                1990                1995                2000
Gln Ala Val Glu His His Lys Lys Ala Gln Ala Glu Leu Ser Ser Phe 
                 2005                2010                2015
Lys Ile Leu Leu Asp Asp Thr Gln Ser Glu Ala Ala Arg Val Leu Ala 
             2020                2025                2030
Asp Asn Leu Lys Leu Lys Lys Glu Leu Gln Ser Asn Lys Glu Ser Ile 
         2035                2040                2045
Lys Ser Gln Ile Lys Gln Lys Asp Glu Asp Leu Leu Arg Arg Leu Glu 
     2050                2055                2060
Gln Ala Glu Glu Lys His Arg Lys Glu Lys Lys Asn Met Gln Glu Lys 
 2065                2070                2075                2080
Leu Asp Ala Leu His Arg Glu Lys Ala His Val Glu Asp Thr Leu Ala 
                 2085                2090                2095
Glu Ile Gln Val Ser Leu Thr Arg Lys Asp Lys Asp Met Lys Glu Leu 
             2100                2105                2110
Gln Gln Ser Leu Asp Ser Thr Leu Ala Gln Leu Ala Ala Phe Thr Lys 
         2115                2120                2125
Ser Met Ser Ser Leu Gln Asp Asp Arg Asp Arg Val Ile Asp Glu Ala 
     2130                2135                2140
Lys Lys Trp Glu Gln Arg Phe Gly Asp Ala Ile Gln Thr Lys Glu Glu 
 2145                2150                2155                2160
Glu Val Arg Leu Lys Glu Glu Asn Cys Thr Ala Leu Lys Asp Gln Leu 
                 2165                2170                2175
Arg Gln Met Thr Ile His Met Glu Glu Leu Lys Ile Thr Val Ser Arg 
             2180                2185                2190
Leu Glu His Asp Lys Glu Ile Trp Glu Ser Lys Ala Gln Thr Glu Leu 
         2195                2200                2205
Gln His Gln Gln Lys Ala Tyr Asp Lys Leu Gln Glu Glu Asn Lys Glu 
     2210                2215                2220
Leu Met Ser Gln Leu Glu Glu Ala Gly Gln Leu Tyr His Asp Ser Lys 
 2225                2230                2235                2240
Asn Glu Leu Thr Lys Leu Glu Ser Glu Leu Lys Ser Leu Lys Asp Gln 
                 2245                2250                2255
Ser Thr Asp Leu Lys Asn Ser Leu Glu Lys Cys Arg Glu His Glu Asn 
             2260                2265                2270
Asn Leu Glu Gly Ile Ile Lys Gln Gln Glu Ala Asp Ile Gln Asn Cys 
         2275                2280                2285
Lys Phe Asn Cys Glu Gln Leu Glu Thr Asp Leu Thr Ala Ser Arg Glu 
     2290                2295                2300
Leu Thr Thr Arg Leu His Asp Glu Ile Asn Val Lys Glu Gln Lys Ile 
 2305                2310                2315                2320
Ile Ser Leu Leu Ser Gly Lys Glu Glu Ala Ile Gln Val Ala Ile Ala 
                 2325                2330                2335
Glu Leu His Gln Gln His Ser Lys Glu Ile Lys Glu Leu Glu Asn Leu 
             2340                2345                2350
Leu Ser Gln Glu Glu Glu Glu Asn Leu Thr Leu Glu Glu Glu Asn Lys 
         2355                2360                2365
Arg Ala Val Glu Lys Thr Asn Gln Leu Thr Glu Ala Leu Glu Thr Ile 
     2370                2375                2380
Lys Lys Glu Ser Leu Glu Gln Lys Ala Gln Leu Asp Ser Phe Val Lys 
 2385                2390                2395                2400
Ser Met Ser Ser Leu Gln Asp Asp Arg Asp Arg Ile Val Ser Asp Tyr 
                 2405                2410                2415
Arg Gln Leu Glu Glu Arg His Leu Ser Val Ile Leu Glu Lys Asp Glu 
             2420                2425                2430
Leu Ile Gln Asp Ala Ala Ala Glu Asn Asn Lys Leu Lys Glu Glu Ile 
         2435                2440                2445
Arg Gly Leu Arg Gly His Met Asp Asp Leu Asn Ser Glu Asn Ala Lys 
     2450                2455                2460
Leu Asp Ala Glu Leu Ile Gln Tyr Arg Arg Asp Leu Asn Glu Val Ile 
 2465                2470                2475                2480
Thr Ile Lys Asp Ser Gln Gln Arg Gln Leu Leu Glu Ala Gln Leu Gln 
                 2485                2490                2495
Gln Asn Lys Glu Leu Arg Asn Glu Cys Val Lys Leu Glu Gly Arg Leu 
             2500                2505                2510
Lys Gly Ser Glu Ala Glu Lys Gln Ser Leu Gln Met Ser Leu Asp Ala 
         2515                2520                2525
Leu Gln Glu Glu Asn Gln Gly Leu Ser Lys Glu Ile Lys Ser Phe Lys 
     2530                2535                2540
Glu Gln Leu Thr Ala Leu His Glu Glu Gly Ala Leu Ala Val Tyr His 
 2545                2550                2555                2560
Ala Gln Leu Arg Val Arg Glu Glu Glu Val Gln Lys Leu Thr Ala Ala 
                 2565                2570                2575
Leu Ser Ser Ser Gln Lys Arg Thr Val Asp Leu Gln Glu Glu Leu Val 
             2580                2585                2590
Cys Val Gln Lys Glu Ala Ser Lys Lys Val Ser Glu Ile Glu Asp Lys 
         2595                2600                2605
Leu Lys Arg Glu Leu Lys His Leu His His Asn Ala Gly Ile Met Arg 
     2610                2615                2620
Asn Glu Thr Glu Thr Ala Glu Glu Arg Val Ala Glu Leu Ala Arg Asp 
 2625                2630                2635                2640
Leu Val Glu Met Glu Gln Lys Leu Leu Thr Val Thr Lys Glu Asn Lys 
                 2645                2650                2655
Asp Leu Thr Ala Gln Ile Gln Ala Phe Gly Lys Ser Met Ser Ser Leu 
             2660                2665                2670
Gln Asp Ser Arg Asp His Ala Thr Glu Glu Leu Ser Asp Leu Lys Lys 
         2675                2680                2685
Lys Tyr Asp Ala Ser Leu Lys Glu Leu Ala Gln Leu Lys Gly Arg Gln 
     2690                2695                2700
Asp Leu Gly Arg Glu Ser Asp Val Leu Ser Gln Ala Ala Phe Pro Leu 
 2705                2710                2715                2720
Thr Thr Ser Glu Asn Ile Ser Ser Arg Leu Glu Lys Leu Asn Gln Gln 
                 2725                2730                2735
Leu Ile Ser Lys Asp Glu Gln Leu Leu His Leu Ser Ser Glu Leu Glu 
             2740                2745                2750
Ser Ser His Asn Gln Val Gln Ser Phe Thr Lys Ala Met Thr Ser Leu 
         2755                2760                2765
Gln Asn Glu Arg Asp His Leu Trp Asn Glu Leu Glu Lys Phe Arg Lys 
     2770                2775                2780
Ser Glu Glu Gly Lys Gln Arg Ser Ala Ala Pro Ser Ala Ala Ser Ser 
 2785                2790                2795                2800
Pro Ala Glu Val Gln Ser Leu Lys Lys Ala Met Ser Ser Leu Gln Asn 
                 2805                2810                2815
Asp Arg Asp Arg Leu Leu Lys Glu Leu Lys Asn Leu Gln Gln Gln Tyr 
             2820                2825                2830
Leu Gln Met Asn Gln Glu Ile Thr Glu Leu Arg Pro Leu Lys Ala Gln 
         2835                2840                2845
Leu Gln Glu Ser Gln Asp Gln Thr Lys Ala Leu Gln Met Met Lys Glu 
     2850                2855                2860
Glu Leu Arg Gln Glu Asn Leu Ser Trp Gln His Glu Leu Asp Gln Leu 
 2865                2870                2875                2880
Arg Val Glu Lys Asn Ser Trp Glu Leu His Glu Arg Arg Met Lys Glu 
                 2885                2890                2895
Gln Tyr Leu Met Ala Ile Ser Asp Lys Asp Gln Gln Leu Gly His Leu 
             2900                2905                2910
Gln Asn Leu Leu Arg Glu Leu Arg Ser Ser Ser Gln Thr Gln Ile Leu 
         2915                2920                2925
Pro Thr Gln Tyr Gln Arg Gln Ala Ser Ser Gly Thr Ser Ala Ala Leu 
     2930                2935                2940
Asp Gly Ser Gln Asn Leu Val Tyr Glu Thr Asp Cys Leu Arg Thr Gln 
 2945                2950                2955                2960
Leu Asn Asp Ser Leu Lys Glu Ile His Gln Lys Glu Leu Arg Ile Gln 
                 2965                2970                2975
Gln Leu Asn Ser Lys Phe Ser Gln Leu Leu Glu Glu Lys Asn Ile Leu 
             2980                2985                2990
Ser Thr Gln Leu Arg Asp Ala Asn Gln Ser Leu Arg Asp Ser Gln His 
         2995                3000                3005
His Tyr Ser Asn Leu Phe Asn His Cys Ala Ile Leu Glu Arg Gln Val 
     3010                3015                3020
Gln Gln Leu Gln Ala Thr Gly Pro Leu Asn Ala Asp Val Ala Pro Gly 
 3025                3030                3035                3040
Ala Pro Gln Glu Lys Asp Gly Ile His Ile Lys Thr Glu Thr Glu Thr 
                 3045                3050                3055
Thr Gly Glu Glu Gln Pro Ser Phe Ser Glu Val Gln Gln Gln Leu Cys 
             3060                3065                3070
Asn Thr Lys His Asp Leu Ser Glu Leu Lys Lys Leu Leu Glu Glu Glu 
         3075                3080                3085
Arg Asp Gln Arg Leu Thr Ala Glu Asn Ala Leu Ser Leu Ala Lys Glu 
     3090                3095                3100
Gln Ile Arg Arg Leu Glu His Ser Glu Trp Glu Ser Ala Arg Thr Pro 
 3105                3110                3115                3120
Ile Ile Gly Ala Cys Gly Ser Gln Glu Gln Val Leu Leu Met Asp Leu 
                 3125                3130                3135
Pro Gly Ser Ser Cys Arg Arg Thr Arg Ser Ser Ala Gly Trp Lys Arg 
             3140                3145                3150
Val Leu Arg Ser Leu Cys Arg Ser Arg Thr Arg Val Pro Leu Leu Ala 
         3155                3160                3165
Ala Ile Tyr Phe Leu Met Ile His Val Leu Leu Val Leu Cys Phe Thr 
     3170                3175                3180
Gly His Leu 
 3185



<210> 1871
<211> 10300
<212> DNA
<213> Homo sapiens
<308> X75304
<400> 1871

aactgctag  ggctgagtc  ctggcgggg  gcggcggtg  aaggtgtcg  gtacgggct  60
cccgagctg  cgtggcttg  attgggagg  gggcagctg  agcctcagg  ggcagcgct  120
ctagaaatg  tgagccgat  atcaggatt  gcaaatgtt  ttttgcatg  attatcagg  180
gatgatgac  ctgatcaga  tatgagggc  cccctagac  ctgaattac  ccaagaatc  240
gacatggaa  ttaataata  tacacaaga  gatgttcag  agcgcctgg  ttatgcaga  300
caattggtg  tggagctaa  agatattat  agacagaag  atgttcaac  gcagcagaa  360
gatgaagct  tacaggaag  gagaaaagc  gctgataac  aaattaaaa  actaaaact  420
catgcgaag  ccaaattaa  ttctttgaa  aaatacata  aagaaatga  agcacaagg  480
gggactgtt  tgcctacag  acctcagtc  gaggagcaa  tttccaagc  tgacaagag  540
tctacagag  aagagatgg  aatagaaaa  ataaaacat  agctccagg  gaaggagga  600
ctaatcagc  ctttgcaag  ccagcttac  caggcacag  cagaacaac  tgcacagag  660
tctacagag  tggaagaat  tgtaatgat  aagcaacag  tccaggaga  ggaagaatt  720
attagcact  tacaagccc  gctcagcca  acacaggca  agcaagctg  acagcaggt  780
gtccgagag  aagatgccc  ctttgaaac  caagttcgt  ttcatgaag  tgagcttct  840
cagttagta  cccaggcag  tgtggaaac  gagatgcaa  agaaattga  ggtgctgca  900
aggaagctt  aggaacacg  agaatcctt  gtgggccgt  ctcaggtcg  tgacttgct  960
caacaggag  tgactgctg  tgagcagag  aaccagatt  tctctcagc  gttacagca  1020
atggaagct  agcataata  tttgaggaa  actgtggaa  cagaaagag  ggagtccaa  1080
attctactg  aaaagatgg  acttgaagt  gcagagaga  aattatcct  ccataatct  1140
caggaagaa  tgcatcatc  tttagaaca  tttgagcaa  caggccaag  ccaggctga  1200
ctagagtct  ggtatagtg  tttggagca  aagcacaaa  cagaaatgg  agagaagac  1260
tctcatatt  tgagtcttc  aaagactgg  caagagctg  agtctgcct  tgatgctct  1320
aaggatcaa  attcaaagc  tctccaaga  aagaatgaa  aggcagttc  gtcagccca  1380
accattcag  aactggaag  tcagctcca  caaaaatcc  aagaaatta  ccaatttct  1440
aatagactg  ccttgcaac  acatgaaac  gcatctcag  cttctttcc  agatgttta  1500
aatgagggc  cacaggcag  cactgagga  aatattgct  ctttgcaga  gagagtggt  1560
gaactagag  atgaaaagg  agccttgct  cttagttct  tagagctgg  ggagctgaa  1620
gctgagaat  aaaaactgt  ttctcagat  actctccta  aggctcaga  tagaactgg  1680
gaggcagac  gagaagtca  tgagatcag  attgttgat  ttgccaaca  gaggagctc  1740
tctgctgag  aaagtggac  agatgttct  gaaaacaca  tttctcaga  acataaaga  1800
ttatcagtt  tattgttgg  aatgaaaga  gctcaagag  aaattgcat  tcttaaatt  1860
cagctccag  gaaaaaggg  tgaggaagc  gatcatgag  tccttgacc  gaaagaaat  1920
aaacagatg  agggtgagg  aatagctcc  attaaaatg  aagtatttc  tgaagatac  1980
gggcaagat  ttcccttaa  gccaaatga  gagagcagt  ttccagcag  tgaaaaaga  2040
caggcgagc  ctgaacatc  aagtagaac  tctgaggaa  tatctttaa  tgatgctgg  2100
gtagaattg  aatcaacaa  gcaggatgg  gataaatcc  tttctgctg  accagatat  2160
ggtcagtgt  atcaggatg  gttggaaag  ttaaaaagt  aaattttgg  gctcgagct  2220
aactttcat  aagcacaag  aatctatga  aaaaattta  atgagaaag  taaggaaat  2280
agcaaccta  accagttga  tgaggagtt  aagaaaaat  ctgacaaca  cagcagtgc  2340
ttcactgct  tgtctgaag  aagagacca  cttctctct  aggtgaagg  acttagcat  2400
gtaacagaa  tgagggctc  ggtaaagca  ctggaaatg  accttgcag  agcagaaag  2460
caaagaaga  ttgattatg  aagccaaac  gcccatgac  acctgctca  tgaacagat  2520
catagtctc  gcatagaag  caaatctaa  gatgtgaaa  ttgaagttt  acagaatga  2580
ctggatgat  tgcagcttc  gttttctga  cagagtacc  tgataagaa  cctgcaaag  2640
cagctgcaa  ataaggaaa  tgaagtgct  gagggggca  aacgtgtaa  gcatatctc  2700
agtaaagtg  aagaactgt  ccaggctct  tcacagaag  aacttgaaa  aacaaaaat  2760
gatcagctc  tactagaga  aaagagaga  gtggaaacc  tccaacaaa  catcgagga  2820
aaggatcaa  aagtgacag  aatcagctt  agtatgact  agaaaatgg  tcagcttaa  2880
gaagagaag  tttctcttg  ggttgaaat  aagactctt  aagaacagc  aaatttatt  2940
tccagagct  aggaagcaa  aaaagagca  gtggaagaa  ataatgaag  ttcttctgg  3000
cttaaacaa  attatgatg  gatgagccc  gcaggacaa  taagtaagg  agaacttca  3060
catgaattt  accttctga  gaaagaaaa  gagcagaga  agagaaagc  ccaggcagc  3120
cttattaac  gaaaggagc  tctgcaaag  gtcagtaga  tggaagaag  attagccaa  3180
ttgaaagat  aatctaaga  agaaatccc  ctcagtgag  ctgagaggg  agaagtgga  3240
gaagataaa  aaaacaaag  atactcaga  aaatgtgtg  cttctaagt  ccaagaaat  3300
gaaatttat  taaaacaga  aatatctga  aaagaagtg  aactacagc  tataaggaa  3360
gatttggaa  aaaagctgg  agctgaaga  caattccag  ctctggtca  acagatgaa  3420
cagaccttg  aagataaaa  aaaccaaat  gatttgctc  aagcagaaa  cagtgaaaa  3480
caagcaatt  tccagaagt  aatcacaag  aacacggat  caagtgatg  ggactccgt  3540
gcacttgta  aggaaacag  ggtgataag  ccaccttgt  caggtagta  tgaacactg  3600
aaaccagaa  tagaagaaa  gatactggc  cttgaaaaa  aaaaggagc  acttcaaaa  3660
aagctacag  aagccttaa  ctcccgcaa  gcaattctt  aaaaggcac  ggagaaaga  3720
agacatctc  gggaggagc  aaagcaaca  aaagatgac  ataatcgct  gcaagaaca  3780
tttgatgag  aaagcaagg  aaatgagaa  attggagac  agctaaggc  actccagat  3840
caagtaagg  aatccatag  cggaaaact  ccaagcaca  accagcagg  atcgtgttc  3900
tccactcca  gtttagaag  acctttatt  aaagccaca  aacagcatc  cactcaacc  3960
gttttagag  ccaacttgt  cccagactg  ccttctcat  ctgaagatg  gagtgctct  4020
cagggcgga  cttctgttg  ccagattaa  gcccagctg  aggaaatag  ggctgagaa  4080
gtagagtta  aattgaaag  tagttctac  acaagtgag  ttactaaaa  atcagaaga  4140
gtatttcag  tacaagagc  gataaataa  cagggttta  aaatcgaga  tctaaagac  4200
gtatcccat  aagctgaag  ccatgccga  agcctgcag  agaaattgg  aagcagcca  4260
ctacaaatt  ctggcctag  acatctaag  gaattgcaa  ctaaactgg  tgaactgca  4320
aaactcata  gcaaaaagg  agaagacgt  agctacctt  ctggacaac  tagtgagaa  4380
gaagcagct  tcactaaaa  acagacaga  ataatagaa  aagaagatt  aattaaggc  4440
ctgcataca  agctagaaa  gcaagccaa  gagcatgat  agaggataa  gcagctaca  4500
gtggaactt  gtgaaatga  gcaaaaacc  gaagagatt  gagaagaaa  tagagcaaa  4560
caacaaata  aaaggaaac  gcaagctgc  cttatttcc  gaaaagaag  actaaaaga  4620
aacaaaagt  tccaagagg  attgtcttt  gccagaggt  ccattgaac  tctcaccaa  4680
tctctggca  atgtggaaa  ccaagtttc  gctcaaaat  aagaaaaag  tacggtctt  4740
ggaaggtta  ctcttcttc  agaagaaag  gacaaactc  ttacagaaa  ggacaggtc  4800
ttattggaa  atcagagtc  cagcagctc  tgtgaaagt  taaaactag  tctagaggg  4860
cttactgaa  acaaggaaa  gttagtgaa  gaaattgaa  ctttgaaat  ttctaagat  4920
gcagaaagt  ctgagtggc  agagaaaca  aaggagcta  aaaaagagt  tgaaattct  4980
ctgcagtcc  atgagaatg  tagtaatga  gcagaaagg  ttcagcatg  ggtggaagc  5040
gtgaggcaa  agaaacaag  actgtatgg  aagttaaga  gcacagagg  aaacaagaa  5100
gagacagaa  agcagttgc  ggaagctga  caagaaatg  aggaaatga  agaaaagat  5160
agaaagttt  ctaaatcta  acagcagaa  atcctagag  tggaagaag  gaatgaccg  5220
cttagggca  aggtgcacc  tgcaggaga  acagctaaa  agtgtatgg  aacacttct  5280
tcttccaat  ccagcatga  ggaagaact  gaaagggtc  aaatggagt  tgaaaccct  5340
tctaagaag  ttcagtctt  aatgtctga  aaagactct  taagtgaag  ggttcaaga  5400
ttaaagcat  agatagaag  taatgtatc  aaacaagct  acctagagg  caccgagaa  5460
catgataac  aaacgaatg  cactgaaga  ggaacacag  ctataccag  tgagactga  5520
gagcaagac  ctctgagta  gagcacaag  cctacatgt  cagaatcgg  tccatcagc  5580
aagagtgcc  accctgctg  aagtaagga  ttcagctca  atgatgaaa  taataacta  5640
ctacagcag  ttgatcagc  caaagaaag  attgctgga  tagaggagg  gaagcagaa  5700
aacaaggaa  ttagccaga  tttagaaaa  gagaaaaat  ccttactga  tcagatatc  5760
acaaaggat  gtgaactaa  aatgcttca  gaggaagta  ccaaaatga  cctgttaaa  5820
cagcaaatc  aagaagaac  ctccagagt  accaaacta  aggagacag  agaagaaga  5880
aaagatgat  tggaagaga  gcttatgaa  caattagca  aacttaatg  aagcattgg  5940
aattactgt  aggatgtta  agatgccca  ataaaaaat  agctattgg  atctgaaat  6000
aagaacctt  aaaagtgtg  gagtgaatt  gaagaagaa  agcagcagt  agtcaagga  6060
aaaactaag  tggaatcag  aatacgaaa  gaatatttg  agaaaatac  aggtgctca  6120
aaagaaccc  gaaataaaa  ccatgcaaa  gaacttcag  aactgttaa  agaaaaaca  6180
caagaagta  agcagctac  gaaggactg  atcaggtat  aagagaaaa  tagtgctct  6240
gagagaact  ttaaagctc  agaatttgt  caaactgaa  ctcaaaaag  tttggaaat  6300
accaaagaa  atctggctc  agcagttga  caccgcaaa  aggcacaag  agaattagc  6360
agcttcaaa  tcctgctag  tgacactca  agtgaagca  caagggtcc  agcagacaa  6420
ctcaagttg  aaaaggaac  tcagtcaaa  aaagaatca  ttaaaagcc  gatgaaaca  6480
aaggatgaa  atcttgagc  aagactgga  caggcagaa  agaagcacc  gaaagagaa  6540
aagaatatg  aagagaaac  ggatgcttt  cgcagagaa  aagtccact  ggaagagac  6600
attggagag  ttcaggtta  tttgaacaa  aaagacaag  aagttcagc  acttcagga  6660
aacttggac  gtactgtga  ccagcttgc  gcctttact  agagcatgt  ttccctcca  6720
gatgatcgt  acagggtga  agatgaagc  aagaaatgg  agaggaagt  tagtgatgc  6780
attcaaagc  aagaagaag  aattagact  aaagaagat  attgcagtg  tctaaagga  6840
caacttaga  agatgtcca  ccatatgga  gaattaaag  ttaacattt  caggcttga  6900
catgacaag  agatttggg  gtccaaggc  cagacagag  tccagcttc  gcagaaggt  6960
tgtgatact  tacaggggg  aaacaaaga  cttttgtcc  agctagaag  gacacgcca  7020
ctataccac  gttctcaga  tgaattagc  aagttggaa  cagaactta  gagtctcaa  7080
gaccagttg  ctgatttaa  taactcttt  gaaaaatgt  aggaacaaa  aggaaactt  7140
gaagggatc  taaggcagc  agaggctga  attcaaaat  ctaagttca  ttatgaaca  7200
ctggagact  atcttcagg  ctccagaga  ctgaccagt  ggctgcatg  agaaataaa  7260
atgaaagag  aaaagatta  aagcctgct  tctggcaag  aagaggcaa  ccaagtagc  7320
attgctgaa  tgcgtcagc  acatgataa  gaaattaaa  agctggaaa  cctgctgtc  7380
caggaggaa  aggagaata  tgttttaga  gaggagaac  aaaaggctg  tgataaaac  7440
aatcagctt  tggaaacac  gaaaaccat  aaaaaggaa  acattcagc  aaaggcaca  7500
ttggattcc  ttgttaaat  catgtcttc  ctccaaaat  atcgagacc  catagtggg  7560
gactatcaa  agctggaag  gcgacatct  tctataatc  tggaaaaag  ccaactcat  7620
caagaggct  ctgcagaga  taataagct  aaagaagaa  tacgaggct  gagaagtca  7680
atggatgat  tcaattctg  gaatgccaa  ctagatgca  aactgatcc  atatagaga  7740
gacctgaac  aagtgataa  aataaagga  agccaacaa  agcagcttc  tgaagttca  7800
cttcagcaa  ataaggagc  ggaaaataa  tatgctaaa  tagaagaaa  gctgaagga  7860
tctgaggaa  caaatgagg  tctgcggag  tcctttaat  ccctacaag  agagaaaca  7920
gatttatct  aagagattg  gagtttgaa  gtatctata  cccagctaa  aagacaagt  7980
acagccttg  aagaagaag  tactttagg  ctctatcat  cccagttaa  agtaaaaga  8040
gaagaggta  acaggttaa  tgctttgtt  tcctcctct  aaaagagaa  tgcagaact  8100
gaagaagaa  tggtttgtg  tcaaaagga  gctgccaag  aggtaggtg  aattgaaga  8160
aaactgaag  aagaattaa  gcatcttca  catgatgca  ggataatga  aaatgaaac  8220
gaaacagca  aagagagag  ggcagagct  gcaagagat  tggtggaga  ggaacagaa  8280
ttactcatg  tcaccaaag  aaataaagg  ctcacagca  aaattcagt  ttttggaag  8340
tctatgagt  ccttgcaaa  tagtagaga  catgccaat  aggaacttg  tgaactgaa  8400
aggaaatat  atgccagtc  gaaggaatt  gcacagttg  aagaacagg  actcttaaa  8460
agagagaga  atgctcttc  ttctgaaac  gccttttca  tgaactcca  tgaggagaa  8520
agcttgtct  accttgaga  acttaacca  cagctccta  ccaaagatg  gcaattgct  8580
cacttgtcc  cacaactag  agattctta  aaccaagtg  agtcctttt  caaggctat  8640
gccagtctg  agaatgaga  agatcacct  tggaatgag  tggagaaat  tcgaaagtc  8700
gaggaaggg  agcagaggt  tgcagctca  ccttccacc  gcccagctg  agtacagag  8760
ttaaaaaaa  ctatgtctt  actccaaaa  gacagagac  gactactga  ggaattgaa  8820
aatctgcag  agcaatact  acagattaa  caagagatc  ctgagttac  tccactgaa  8880
gctcaactt  aggagtatc  agataagac  aaagcattt  agattatgc  agaagagct  8940
aggcaggaa  acctctcct  gcagcatga  ctgcatcag  tcaggatgg  gaagagttc  9000
tgggaaata  atgagagga  aatgaagga  cagtacctt  tggctatct  agataaaga  9060
cagcagctc  gtcatctgc  gaatcttat  agggaattg  ggtcttctt  ctcccagac  9120
cagcctctc  aagtgcaat  ccaaagaca  gcatcccca  agacatcag  ttccccaga  9180
gggtcacaa  atctggttt  tgagacaga  cttctcagg  cccagctca  tgacagctt  9240
aaggaaatt  accaaaagg  gttaagaat  cagcaactg  acagcaact  ctctcagct  9300
ctggaagag  aaaacaccc  ttccattca  ctctgcgat  ccagtcaga  tcttcgtga  9360
aaccagcag  actatggtg  ccttttaaa  cactgtgca  tcttggaga  gcaggttca  9420
gagctgcag  cggggccac  aaatataga  gttgctcca  gagctcccc  ggaaaagaa  9480
ggagttcac  gaaagagtg  ccctgagga  ctaagggaa  cgcagcaaa  cttttctga  9540
gctcagcag  agctatgca  caccagaca  gaagtgaat  aattaagga  gctgctgga  9600
gaagaacga  accaaagag  ggctgctga  aatgctctc  ctgtggccg  ggagcagat  9660
agacggtta  agcacagtg  atgggactc  tcccggact  ctatcattg  ctcctgtgg  9720
actcaggag  aggcactgt  aatagatct  acaagcaac  gttgtcgaa  gacccggag  9780
ggcgttgga  ggaagcgag  cctgcgttc  ctctgtcat  cacggaccc  agtgccact  9840
ctagcagcc  tctactttc  aatgattca  gtcctgctc  ttctgtgtt  tacgggcca  9900
ctatagact  agttgttac  ctttggacc  ctcccttca  aacttggaa  tctctcacc  9960
ctaacatca  aacatcaat  ccagtggaa  agtcttccc  tttacaggt  ttctctcca  10020
ctcttcacg  aaagtgcct  caaaaacag  ggtggatac  aggacaggt  ggagctgca  10080
ggactggcg  gtctgcttt  ttctactgc  ctgagcctg  acgcttctg  ttaatctga  10140
aatcacatt  ggtttgttg  gcctaatat  tgttgagat  ttgcaggac  ctgatcttt  10200
gtggtcctg  aaaagatac  gaggaatgt  tttcagcca  gccaagagg  tggtttcaa  10260
aaacctaat  atctgaagt  cagcttttt  tttttttttt  10300



<210> 1872
<211> 3259
<212> PRT
<213> Homo sapiens
<308> CAA53052
<400> 1872

Met Leu Ser Arg Leu Ser Gly Leu Ala Asn Val Val Leu His Glu Leu 
  1               5                  10                  15
Ser Gly Asp Asp Asp Thr Asp Gln Asn Met Arg Ala Pro Leu Asp Pro 
             20                  25                  30
Glu Leu His Gln Glu Ser Asp Met Glu Phe Asn Asn Thr Thr Gln Glu 
         35                  40                  45
Asp Val Gln Glu Arg Leu Ala Tyr Ala Glu Gln Leu Val Val Glu Leu 
     50                  55                  60
Lys Asp Ile Ile Arg Gln Lys Asp Val Gln Leu Gln Gln Lys Asp Glu 
 65                  70                  75                  80
Ala Leu Gln Glu Glu Arg Lys Ala Ala Asp Asn Lys Ile Lys Lys Leu 
                 85                  90                  95
Lys Leu His Ala Lys Ala Lys Leu Thr Ser Leu Asn Lys Tyr Ile Glu 
             100                105                110
Glu Met Lys Ala Gln Gly Gly Thr Val Leu Pro Thr Glu Pro Gln Ser 
         115                120                125
Glu Glu Gln Leu Ser Lys His Asp Lys Ser Ser Thr Glu Glu Glu Met 
     130                135                140
Glu Ile Glu Lys Ile Lys His Lys Leu Gln Glu Lys Glu Glu Leu Ile 
 145                150                155                160
Ser Thr Leu Gln Ala Gln Leu Thr Gln Ala Gln Ala Glu Gln Pro Ala 
                 165                170                175
Gln Ser Ser Thr Glu Met Glu Glu Phe Val Met Met Lys Gln Gln Leu 
             180                185                190
Gln Glu Lys Glu Glu Phe Ile Ser Thr Leu Gln Ala Gln Leu Ser Gln 
         195                200                205
Thr Gln Ala Glu Gln Ala Ala Gln Gln Val Val Arg Glu Lys Asp Ala 
     210                215                220
Arg Phe Glu Thr Gln Val Arg Leu His Glu Asp Glu Leu Leu Gln Leu 
 225                230                235                240
Val Thr Gln Ala Asp Val Glu Thr Glu Met Gln Gln Lys Leu Arg Val 
                 245                250                255
Leu Gln Arg Lys Leu Glu Glu His Glu Glu Ser Leu Val Gly Arg Ala 
             260                265                270
Gln Val Val Asp Leu Leu Gln Gln Glu Leu Thr Ala Ala Glu Gln Arg 
         275                280                285
Asn Gln Ile Leu Ser Gln Gln Leu Gln Gln Met Glu Ala Glu His Asn 
     290                295                300
Thr Leu Arg Asn Thr Val Glu Thr Glu Arg Glu Glu Ser Lys Ile Leu 
 305                310                315                320
Leu Glu Lys Met Glu Leu Glu Val Ala Glu Arg Lys Leu Ser Phe His 
                 325                330                335
Asn Leu Gln Glu Glu Met His His Leu Leu Glu Gln Phe Glu Gln Ala 
             340                345                350
Gly Gln Ala Gln Ala Glu Leu Glu Ser Arg Tyr Ser Ala Leu Glu Gln 
         355                360                365
Lys His Lys Ala Glu Met Glu Glu Lys Thr Ser His Ile Leu Ser Leu 
     370                375                380
Gln Lys Thr Gly Gln Glu Leu Gln Ser Ala Cys Asp Ala Leu Lys Asp 
 385                390                395                400
Gln Asn Ser Lys Leu Leu Gln Asp Lys Asn Glu Gln Ala Val Gln Ser 
                 405                410                415
Ala Gln Thr Ile Gln Gln Leu Glu Asp Gln Leu Gln Gln Lys Ser Lys 
             420                425                430
Glu Ile Ser Gln Phe Leu Asn Arg Leu Pro Leu Gln Gln His Glu Thr 
         435                440                445
Ala Ser Gln Thr Ser Phe Pro Asp Val Tyr Asn Glu Gly Thr Gln Ala 
     450                455                460
Val Thr Glu Glu Asn Ile Ala Ser Leu Gln Lys Arg Val Val Glu Leu 
 465                470                475                480
Glu Asn Glu Lys Gly Ala Leu Leu Leu Ser Ser Ile Glu Leu Glu Glu 
                 485                490                495
Leu Lys Ala Glu Asn Glu Lys Leu Ser Ser Gln Ile Thr Leu Leu Glu 
             500                505                510
Ala Gln Asn Arg Thr Gly Glu Ala Asp Arg Glu Val Ser Glu Ile Ser 
         515                520                525
Ile Val Asp Ile Ala Asn Lys Arg Ser Ser Ser Ala Glu Glu Ser Gly 
     530                535                540
Gln Asp Val Leu Glu Asn Thr Phe Ser Gln Lys His Lys Glu Leu Ser 
 545                550                555                560
Val Leu Leu Leu Glu Met Lys Glu Ala Gln Glu Glu Ile Ala Phe Leu 
                 565                570                575
Lys Leu Gln Leu Gln Gly Lys Arg Ala Glu Glu Ala Asp His Glu Val 
             580                585                590
Leu Asp Gln Lys Glu Met Lys Gln Met Glu Gly Glu Gly Ile Ala Pro 
         595                600                605
Ile Lys Met Lys Val Phe Leu Glu Asp Thr Gly Gln Asp Phe Pro Leu 
     610                615                620
Met Pro Asn Glu Glu Ser Ser Leu Pro Ala Val Glu Lys Glu Gln Ala 
 625                630                635                640
Ser Thr Glu His Gln Ser Arg Thr Ser Glu Glu Ile Ser Leu Asn Asp 
                 645                650                655
Ala Gly Val Glu Leu Lys Ser Thr Lys Gln Asp Gly Asp Lys Ser Leu 
             660                665                670
Ser Ala Val Pro Asp Ile Gly Gln Cys His Gln Asp Glu Leu Glu Arg 
         675                680                685
Leu Lys Ser Gln Ile Leu Glu Leu Glu Leu Asn Phe His Lys Ala Gln 
     690                695                700
Glu Ile Tyr Glu Lys Asn Leu Asp Glu Lys Ala Lys Glu Ile Ser Asn 
 705                710                715                720
Leu Asn Gln Leu Ile Glu Glu Phe Lys Lys Asn Ala Asp Asn Asn Ser 
                 725                730                735
Ser Ala Phe Thr Ala Leu Ser Glu Glu Arg Asp Gln Leu Leu Ser Gln 
             740                745                750
Val Lys Glu Leu Ser Met Val Thr Glu Leu Arg Ala Gln Val Lys Gln 
         755                760                765
Leu Glu Met Asn Leu Ala Glu Ala Glu Arg Gln Arg Arg Leu Asp Tyr 
     770                775                780
Glu Ser Gln Thr Ala His Asp Asn Leu Leu Thr Glu Gln Ile His Ser 
 785                790                795                800
Leu Ser Ile Glu Ala Lys Ser Lys Asp Val Lys Ile Glu Val Leu Gln 
                 805                810                815
Asn Glu Leu Asp Asp Val Gln Leu Gln Phe Ser Glu Gln Ser Thr Leu 
             820                825                830
Ile Arg Ser Leu Gln Ser Gln Leu Gln Asn Lys Glu Ser Glu Val Leu 
         835                840                845
Glu Gly Ala Glu Arg Val Arg His Ile Ser Ser Lys Val Glu Glu Leu 
     850                855                860
Ser Gln Ala Leu Ser Gln Lys Glu Leu Glu Ile Thr Lys Met Asp Gln 
 865                870                875                880
Leu Leu Leu Glu Lys Lys Arg Asp Val Glu Thr Leu Gln Gln Thr Ile 
                 885                890                895
Glu Glu Lys Asp Gln Gln Val Thr Glu Ile Ser Phe Ser Met Thr Glu 
             900                905                910
Lys Met Val Gln Leu Asn Glu Glu Lys Phe Ser Leu Gly Val Glu Ile 
         915                920                925
Lys Thr Leu Lys Glu Gln Leu Asn Leu Leu Ser Arg Ala Glu Glu Ala 
     930                935                940
Lys Lys Glu Gln Val Glu Glu Asp Asn Glu Val Ser Ser Gly Leu Lys 
 945                950                955                960
Gln Asn Tyr Asp Glu Met Ser Pro Ala Gly Gln Ile Ser Lys Glu Glu 
                 965                970                975
Leu Gln His Glu Phe Asp Leu Leu Lys Lys Glu Asn Glu Gln Arg Lys 
             980                985                990
Arg Lys Leu Gln Ala Ala Leu Ile Asn Arg Lys Glu Leu Leu Gln Arg 
         995                1000                1005
Val Ser Arg Leu Glu Glu Glu Leu Ala Asn Leu Lys Asp Glu Ser Lys 
     1010                1015                1020
Lys Glu Ile Pro Leu Ser Glu Thr Glu Arg Gly Glu Val Glu Glu Asp 
 1025                1030                1035                1040
Lys Glu Asn Lys Glu Tyr Ser Glu Lys Cys Val Thr Ser Lys Cys Gln 
                 1045                1050                1055
Glu Ile Glu Ile Tyr Leu Lys Gln Thr Ile Ser Glu Lys Glu Val Glu 
             1060                1065                1070
Leu Gln His Ile Arg Lys Asp Leu Glu Glu Lys Leu Ala Ala Glu Glu 
         1075                1080                1085
Gln Phe Gln Ala Leu Val Lys Gln Met Asn Gln Thr Leu Gln Asp Lys 
     1090                1095                1100
Thr Asn Gln Ile Asp Leu Leu Gln Ala Glu Ile Ser Glu Asn Gln Ala 
 1105                1110                1115                1120
Ile Ile Gln Lys Leu Ile Thr Ser Asn Thr Asp Ala Ser Asp Gly Asp 
                 1125                1130                1135
Ser Val Ala Leu Val Lys Glu Thr Val Val Ile Ser Pro Pro Cys Thr 
             1140                1145                1150
Gly Ser Ser Glu His Trp Lys Pro Glu Leu Glu Glu Lys Ile Leu Ala 
         1155                1160                1165
Leu Glu Lys Glu Lys Glu Gln Leu Gln Lys Lys Leu Gln Glu Ala Leu 
     1170                1175                1180
Thr Ser Arg Lys Ala Ile Leu Lys Lys Ala Gln Glu Lys Glu Arg His 
 1185                1190                1195                1200
Leu Arg Glu Glu Leu Lys Gln Gln Lys Asp Asp Tyr Asn Arg Leu Gln 
                 1205                1210                1215
Glu Gln Phe Asp Glu Gln Ser Lys Glu Asn Glu Asn Ile Gly Asp Gln 
             1220                1225                1230
Leu Arg Gln Leu Gln Ile Gln Val Arg Glu Ser Ile Asp Gly Lys Leu 
         1235                1240                1245
Pro Ser Thr Asp Gln Gln Glu Ser Cys Ser Ser Thr Pro Gly Leu Glu 
     1250                1255                1260
Glu Pro Leu Phe Lys Ala Thr Glu Gln His His Thr Gln Pro Val Leu 
 1265                1270                1275                1280
Glu Ser Asn Leu Cys Pro Asp Trp Pro Ser His Ser Glu Asp Ala Ser 
                 1285                1290                1295
Ala Leu Gln Gly Gly Thr Ser Val Ala Gln Ile Lys Ala Gln Leu Lys 
             1300                1305                1310
Glu Ile Glu Ala Glu Lys Val Glu Leu Glu Leu Lys Val Ser Ser Thr 
         1315                1320                1325
Thr Ser Glu Leu Thr Lys Lys Ser Glu Glu Val Phe Gln Leu Gln Glu 
     1330                1335                1340
Gln Ile Asn Lys Gln Gly Leu Glu Ile Glu Ser Leu Lys Thr Val Ser 
 1345                1350                1355                1360
His Glu Ala Glu Val His Ala Glu Ser Leu Gln Gln Lys Leu Glu Ser 
                 1365                1370                1375
Ser Gln Leu Gln Ile Ala Gly Leu Glu His Leu Arg Glu Leu Gln Pro 
             1380                1385                1390
Lys Leu Asp Glu Leu Gln Lys Leu Ile Ser Lys Lys Glu Glu Asp Val 
         1395                1400                1405
Ser Tyr Leu Ser Gly Gln Leu Ser Glu Lys Glu Ala Ala Leu Thr Lys 
     1410                1415                1420
Ile Gln Thr Glu Ile Ile Glu Gln Glu Asp Leu Ile Lys Ala Leu His 
 1425                1430                1435                1440
Thr Gln Leu Glu Met Gln Ala Lys Glu His Asp Glu Arg Ile Lys Gln 
                 1445                1450                1455
Leu Gln Val Glu Leu Cys Glu Met Lys Gln Lys Pro Glu Glu Ile Gly 
             1460                1465                1470
Glu Glu Ser Arg Ala Lys Gln Gln Ile Gln Arg Lys Leu Gln Ala Ala 
         1475                1480                1485
Leu Ile Ser Arg Lys Glu Ala Leu Lys Glu Asn Lys Ser Leu Gln Glu 
     1490                1495                1500
Glu Leu Ser Leu Ala Arg Gly Thr Ile Glu Arg Leu Thr Lys Ser Leu 
 1505                1510                1515                1520
Ala Asp Val Glu Ser Gln Val Ser Ala Gln Asn Lys Glu Lys Asp Thr 
                 1525                1530                1535
Val Leu Gly Arg Leu Ala Leu Leu Gln Glu Glu Arg Asp Lys Leu Ile 
             1540                1545                1550
Thr Glu Met Asp Arg Ser Leu Leu Glu Asn Gln Ser Leu Ser Ser Ser 
         1555                1560                1565
Cys Glu Ser Leu Lys Leu Ala Leu Glu Gly Leu Thr Glu Asp Lys Glu 
     1570                1575                1580
Lys Leu Val Lys Glu Ile Glu Ser Leu Lys Ser Ser Lys Ile Ala Glu 
 1585                1590                1595                1600
Ser Thr Glu Trp Gln Glu Lys His Lys Glu Leu Gln Lys Glu Tyr Glu 
                 1605                1610                1615
Ile Leu Leu Gln Ser Tyr Glu Asn Val Ser Asn Glu Ala Glu Arg Ile 
             1620                1625                1630
Gln His Val Val Glu Ala Val Arg Gln Glu Lys Gln Glu Leu Tyr Gly 
         1635                1640                1645
Lys Leu Arg Ser Thr Glu Ala Asn Lys Lys Glu Thr Glu Lys Gln Leu 
     1650                1655                1660
Gln Glu Ala Glu Gln Glu Met Glu Glu Met Lys Glu Lys Met Arg Lys 
 1665                1670                1675                1680
Phe Ala Lys Ser Lys Gln Gln Lys Ile Leu Glu Leu Glu Glu Glu Asn 
                 1685                1690                1695
Asp Arg Leu Arg Ala Glu Val His Pro Ala Gly Asp Thr Ala Lys Glu 
             1700                1705                1710
Cys Met Glu Thr Leu Leu Ser Ser Asn Ala Ser Met Lys Glu Glu Leu 
         1715                1720                1725
Glu Arg Val Lys Met Glu Tyr Glu Thr Leu Ser Lys Lys Phe Gln Ser 
     1730                1735                1740
Leu Met Ser Glu Lys Asp Ser Leu Ser Glu Glu Val Gln Asp Leu Lys 
 1745                1750                1755                1760
His Gln Ile Glu Asp Asn Val Ser Lys Gln Ala Asn Leu Glu Ala Thr 
                 1765                1770                1775
Glu Lys His Asp Asn Gln Thr Asn Val Thr Glu Glu Gly Thr Gln Ser 
             1780                1785                1790
Ile Pro Gly Glu Thr Glu Glu Gln Asp Ser Leu Ser Met Ser Thr Arg 
         1795                1800                1805
Pro Thr Cys Ser Glu Ser Val Pro Ser Ala Lys Ser Ala Asn Pro Ala 
     1810                1815                1820
Val Ser Lys Asp Phe Ser Ser His Asp Glu Ile Asn Asn Tyr Leu Gln 
 1825                1830                1835                1840
Gln Ile Asp Gln Leu Lys Glu Arg Ile Ala Gly Leu Glu Glu Glu Lys 
                 1845                1850                1855
Gln Lys Asn Lys Glu Phe Ser Gln Thr Leu Glu Asn Glu Lys Asn Thr 
             1860                1865                1870
Leu Leu Ser Gln Ile Ser Thr Lys Asp Gly Glu Leu Lys Met Leu Gln 
         1875                1880                1885
Glu Glu Val Thr Lys Met Asn Leu Leu Asn Gln Gln Ile Gln Glu Glu 
     1890                1895                1900
Leu Ser Arg Val Thr Lys Leu Lys Glu Thr Ala Glu Glu Glu Lys Asp 
 1905                1910                1915                1920
Asp Leu Glu Glu Arg Leu Met Asn Gln Leu Ala Glu Leu Asn Gly Ser 
                 1925                1930                1935
Ile Gly Asn Tyr Cys Gln Asp Val Thr Asp Ala Gln Ile Lys Asn Glu 
             1940                1945                1950
Leu Leu Glu Ser Glu Met Lys Asn Leu Lys Lys Cys Val Ser Glu Leu 
         1955                1960                1965
Glu Glu Glu Lys Gln Gln Leu Val Lys Glu Lys Thr Lys Val Glu Ser 
     1970                1975                1980
Glu Ile Arg Lys Glu Tyr Leu Glu Lys Ile Gln Gly Ala Gln Lys Glu 
 1985                1990                1995                2000
Pro Gly Asn Lys Ser His Ala Lys Glu Leu Gln Glu Leu Leu Lys Glu 
                 2005                2010                2015
Lys Gln Gln Glu Val Lys Gln Leu Gln Lys Asp Cys Ile Arg Tyr Gln 
             2020                2025                2030
Glu Lys Ile Ser Ala Leu Glu Arg Thr Val Lys Ala Leu Glu Phe Val 
         2035                2040                2045
Gln Thr Glu Ser Gln Lys Asp Leu Glu Ile Thr Lys Glu Asn Leu Ala 
     2050                2055                2060
Gln Ala Val Glu His Arg Lys Lys Ala Gln Ala Glu Leu Ala Ser Phe 
 2065                2070                2075                2080
Lys Val Leu Leu Asp Asp Thr Gln Ser Glu Ala Ala Arg Val Leu Ala 
                 2085                2090                2095
Asp Asn Leu Lys Leu Lys Lys Glu Leu Gln Ser Asn Lys Glu Ser Val 
             2100                2105                2110
Lys Ser Gln Met Lys Gln Lys Asp Glu Asp Leu Glu Arg Arg Leu Glu 
         2115                2120                2125
Gln Ala Glu Glu Lys His Leu Lys Glu Lys Lys Asn Met Gln Glu Lys 
     2130                2135                2140
Leu Asp Ala Leu Arg Arg Glu Lys Val His Leu Glu Glu Thr Ile Gly 
 2145                2150                2155                2160
Glu Ile Gln Val Thr Leu Asn Lys Lys Asp Lys Glu Val Gln Gln Leu 
                 2165                2170                2175
Gln Glu Asn Leu Asp Ser Thr Val Thr Gln Leu Ala Ala Phe Thr Lys 
             2180                2185                2190
Ser Met Ser Ser Leu Gln Asp Asp Arg Asp Arg Val Ile Asp Glu Ala 
         2195                2200                2205
Lys Lys Trp Glu Arg Lys Phe Ser Asp Ala Ile Gln Ser Lys Glu Glu 
     2210                2215                2220
Glu Ile Arg Leu Lys Glu Asp Asn Cys Ser Val Leu Lys Asp Gln Leu 
 2225                2230                2235                2240
Arg Gln Met Ser Ile His Met Glu Glu Leu Lys Ile Asn Ile Ser Arg 
                 2245                2250                2255
Leu Glu His Asp Lys Gln Ile Trp Glu Ser Lys Ala Gln Thr Glu Val 
             2260                2265                2270
Gln Leu Gln Gln Lys Val Cys Asp Thr Leu Gln Gly Glu Asn Lys Glu 
         2275                2280                2285
Leu Leu Ser Gln Leu Glu Glu Thr Arg His Leu Tyr His Ser Ser Gln 
     2290                2295                2300
Asn Glu Leu Ala Lys Leu Glu Ser Glu Leu Lys Ser Leu Lys Asp Gln 
 2305                2310                2315                2320
Leu Thr Asp Leu Ser Asn Ser Leu Glu Lys Cys Lys Glu Gln Lys Gly 
                 2325                2330                2335
Asn Leu Glu Gly Ile Ile Arg Gln Gln Glu Ala Asp Ile Gln Asn Ser 
             2340                2345                2350
Lys Phe Ser Tyr Glu Gln Leu Glu Thr Asp Leu Gln Ala Ser Arg Glu 
         2355                2360                2365
Leu Thr Ser Arg Leu His Glu Glu Ile Asn Met Lys Glu Gln Lys Ile 
     2370                2375                2380
Ile Ser Leu Leu Ser Gly Lys Glu Glu Ala Ile Gln Val Ala Ile Ala 
 2385                2390                2395                2400
Glu Leu Arg Gln Gln His Asp Lys Glu Ile Lys Glu Leu Glu Asn Leu 
                 2405                2410                2415
Leu Ser Gln Glu Glu Glu Glu Asn Ile Val Leu Glu Glu Glu Asn Lys 
             2420                2425                2430
Lys Ala Val Asp Lys Thr Asn Gln Leu Met Glu Thr Leu Lys Thr Ile 
         2435                2440                2445
Lys Lys Glu Asn Ile Gln Gln Lys Ala Gln Leu Asp Ser Phe Val Lys 
     2450                2455                2460
Ser Met Ser Ser Leu Gln Asn Asp Arg Asp Arg Ile Val Gly Asp Tyr 
 2465                2470                2475                2480
Gln Gln Leu Glu Glu Arg His Leu Ser Ile Ile Leu Glu Lys Asp Gln 
                 2485                2490                2495
Leu Ile Gln Glu Ala Ala Ala Glu Asn Asn Lys Leu Lys Glu Glu Ile 
             2500                2505                2510
Arg Gly Leu Arg Ser His Met Asp Asp Leu Asn Ser Glu Asn Ala Lys 
         2515                2520                2525
Leu Asp Ala Glu Leu Ile Gln Tyr Arg Glu Asp Leu Asn Gln Val Ile 
     2530                2535                2540
Thr Ile Lys Asp Ser Gln Gln Lys Gln Leu Leu Glu Val Gln Leu Gln 
 2545                2550                2555                2560
Gln Asn Lys Glu Leu Glu Asn Lys Tyr Ala Lys Leu Glu Glu Lys Leu 
                 2565                2570                2575
Lys Glu Ser Glu Glu Ala Asn Glu Asp Leu Arg Arg Ser Phe Asn Ala 
             2580                2585                2590
Leu Gln Glu Glu Lys Gln Asp Leu Ser Lys Glu Ile Glu Ser Leu Lys 
         2595                2600                2605
Val Ser Ile Ser Gln Leu Thr Arg Gln Val Thr Ala Leu Gln Glu Glu 
     2610                2615                2620
Gly Thr Leu Gly Leu Tyr His Ala Gln Leu Lys Val Lys Glu Glu Glu 
 2625                2630                2635                2640
Val His Arg Leu Ser Ala Leu Phe Ser Ser Ser Gln Lys Arg Ile Ala 
                 2645                2650                2655
Glu Leu Glu Glu Glu Leu Val Cys Val Gln Lys Glu Ala Ala Lys Lys 
             2660                2665                2670
Val Gly Glu Ile Glu Asp Lys Leu Lys Lys Glu Leu Lys His Leu His 
         2675                2680                2685
His Asp Ala Gly Ile Met Arg Asn Glu Thr Glu Thr Ala Glu Glu Arg 
     2690                2695                2700
Val Ala Glu Leu Ala Arg Asp Leu Val Glu Met Glu Gln Lys Leu Leu 
 2705                2710                2715                2720
Met Val Thr Lys Glu Asn Lys Gly Leu Thr Ala Gln Ile Gln Ser Phe 
                 2725                2730                2735
Gly Arg Ser Met Ser Ser Leu Gln Asn Ser Arg Asp His Ala Asn Glu 
             2740                2745                2750
Glu Leu Asp Glu Leu Lys Arg Lys Tyr Asp Ala Ser Leu Lys Glu Leu 
         2755                2760                2765
Ala Gln Leu Lys Glu Gln Gly Leu Leu Asn Arg Glu Arg Asp Ala Leu 
     2770                2775                2780
Leu Ser Glu Thr Ala Phe Ser Met Asn Ser Thr Glu Glu Asn Ser Leu 
 2785                2790                2795                2800
Ser His Leu Glu Lys Leu Asn Gln Gln Leu Leu Ser Lys Asp Glu Gln 
                 2805                2810                2815
Leu Leu His Leu Ser Ser Gln Leu Glu Asp Ser Tyr Asn Gln Val Gln 
             2820                2825                2830
Ser Phe Ser Lys Ala Met Ala Ser Leu Gln Asn Glu Arg Asp His Leu 
         2835                2840                2845
Trp Asn Glu Leu Glu Lys Phe Arg Lys Ser Glu Glu Gly Lys Gln Arg 
     2850                2855                2860
Ser Ala Ala Gln Pro Ser Thr Ser Pro Ala Glu Val Gln Ser Leu Lys 
 2865                2870                2875                2880
Lys Ala Met Ser Ser Leu Gln Asn Asp Arg Asp Arg Leu Leu Lys Glu 
                 2885                2890                2895
Leu Lys Asn Leu Gln Gln Gln Tyr Leu Gln Ile Asn Gln Glu Ile Thr 
             2900                2905                2910
Glu Leu His Pro Leu Lys Ala Gln Leu Gln Glu Tyr Gln Asp Lys Thr 
         2915                2920                2925
Lys Ala Phe Gln Ile Met Gln Glu Glu Leu Arg Gln Glu Asn Leu Ser 
     2930                2935                2940
Trp Gln His Glu Leu His Gln Leu Arg Met Glu Lys Ser Ser Trp Glu 
 2945                2950                2955                2960
Ile His Glu Arg Arg Met Lys Glu Gln Tyr Leu Met Ala Ile Ser Asp 
                 2965                2970                2975
Lys Asp Gln Gln Leu Ser His Leu Gln Asn Leu Ile Arg Glu Leu Arg 
             2980                2985                2990
Ser Ser Ser Ser Gln Thr Gln Pro Leu Lys Val Gln Tyr Gln Arg Gln 
         2995                3000                3005
Ala Ser Pro Glu Thr Ser Ala Ser Pro Asp Gly Ser Gln Asn Leu Val 
     3010                3015                3020
Tyr Glu Thr Glu Leu Leu Arg Thr Gln Leu Asn Asp Ser Leu Lys Glu 
 3025                3030                3035                3040
Ile His Gln Lys Glu Leu Arg Ile Gln Gln Leu Asn Ser Asn Phe Ser 
                 3045                3050                3055
Gln Leu Leu Glu Glu Lys Asn Thr Leu Ser Ile Gln Leu Cys Asp Thr 
             3060                3065                3070
Ser Gln Ser Leu Arg Glu Asn Gln Gln His Tyr Gly Asp Leu Leu Asn 
         3075                3080                3085
His Cys Ala Val Leu Glu Lys Gln Val Gln Glu Leu Gln Ala Gly Pro 
     3090                3095                3100
Leu Asn Ile Asp Val Ala Pro Gly Ala Pro Gln Glu Lys Asn Gly Val 
 3105                3110                3115                3120
His Arg Lys Ser Asp Pro Glu Glu Leu Arg Glu Pro Gln Gln Ser Phe 
                 3125                3130                3135
Ser Glu Ala Gln Gln Gln Leu Cys Asn Thr Arg Gln Glu Val Asn Glu 
             3140                3145                3150
Leu Arg Lys Leu Leu Glu Glu Glu Arg Asp Gln Arg Val Ala Ala Glu 
         3155                3160                3165
Asn Ala Leu Ser Val Ala Glu Glu Gln Ile Arg Arg Leu Glu His Ser 
     3170                3175                3180
Glu Trp Asp Ser Ser Arg Thr Pro Ile Ile Gly Ser Cys Gly Thr Gln 
 3185                3190                3195                3200
Glu Gln Ala Leu Leu Ile Asp Leu Thr Ser Asn Ser Cys Arg Arg Thr 
                 3205                3210                3215
Arg Ser Gly Val Gly Trp Lys Arg Val Leu Arg Ser Leu Cys His Ser 
             3220                3225                3230
Arg Thr Arg Val Pro Leu Leu Ala Ala Ile Tyr Phe Leu Met Ile His 
         3235                3240                3245
Val Leu Leu Ile Leu Cys Phe Thr Gly His Leu 
     3250                3255



<210> 1873
<211> 10170
<212> DNA
<213> Rattus norvegicus
<308> D25543
<400> 1873

ggcgcgtcg  tggtggcgc  gcgcttggg  tacccgagc  gacgtggct  agattgggc  60
gggggcgtc  ggagttgtc  gggacggcc  cctacagtg  ttgaagagg  cagaaaagg  120
catcagatc  tctaggact  gagttacgg  cagttgtga  cagccacgt  gatactgag  180
ggcgaaccc  aggccctct  gaagagcag  tggtgctct  aacctctga  caactctgc  240
gaccccact  tgagtcatt  ttctccgtg  ccatggagc  ctccttcag  gatgctgag  300
cgattatcg  gattagcaa  taatgtttt  catgaatta  caggagatt  cactggctg  360
actacaatg  cttcctcgg  agctgaatt  ccccagggt  ctgccatgg  attgaataa  420
agtacccaa  aggacgttc  ggatcgcct  gctgatgca  agaagttag  gctggagct  480
aaggatatc  tcagtaagc  ggatgctca  ctccagcaa  aggacgaag  tctgcagga  540
gaaaaaaaa  gagctgaaa  caaaattaa  aaaataaaa  ttcatgcaa  ggccaagat  600
acgtccttg  acaaacaaa  agaagaatt  aagacacaa  gaggagctg  ctcgcctcc  660
gaagtgcag  cagaggagc  ctccaagca  gataagagt  caacagaag  ggagatgga  720
gtagaaaaa  taaaacatg  actccagga  aaggagaaa  taattagca  tttgcaagc  780
cagctggac  aggcgcagt  agaacaagc  tcccagttg  ataagagtt  tgcggagat  840
gaggacttc  tcctgatga  gcagaagct  caagagaag  aggaactca  cggcgcttt  900
caaacgcag  tcagccaga  acaggcaga  caagctgcc  agaaattga  ggtgatgca  960
aggaagctt  aggaacacg  agaagcctt  ctgggccga  ctcaggttg  ggacctgct  1020
cagaaggag  tgacttctg  agaacagag  aaccaggat  tttcacagc  gttgcagct  1080
ttggaggct  aacacagta  tttaaggaa  accatggaa  cagaaagac  ggagtccaa  1140
atcctgatg  aaaaggtag  actcgaaat  gcagagagg  aggaagagc  gtatcagct  1200
cagggacag  tggagcgag  aggccaagc  caggctgag  tggagatgc  gtacggtac  1260
ctccagcaa  gacatgaga  agaaatgga  gagaagaca  cttgcattt  gcttcttca  1320
aagaacgag  aggagctgc  gtctgcctg  gacgctctg  aggaggaaa  ctccaagct  1380
cttcaggag  agcaggaac  ggctgccaa  tcagcccag  ccctgcagc  gctggaaga  1440
gaactccag  aaaaatcta  agaaattag  caatttgta  acaaaccaa  cttggaaaa  1500
catgagaca  catctcaga  gtctttacc  gatgtttat  atgagggcg  acaggcagt  1560
atggaggag  gtgtcgcct  tttacagaa  agagtacta  agctagaga  tgagaaggg  1620
gccttgctc  ttagttctc  agagctgga  gagctgaga  ctgagaacg  aaaactctg  1680
tctcggatt  ctcttctgg  ggctcagaa  agagcagga  aggctgatg  tatggtctg  1740
gaggtcagc  cagctggta  tgctttgct  aacaggagc  actcttcta  tgaagaaag  1800
ggacaggat  tcctagaga  cacattttc  cagaaacat  aagagctgt  ggttttatt  1860
gtggaaatg  aggaagccc  ggaggaaat  gcatttctt  agtcgcagc  gcagggcaa  1920
aggcctgaa  gggactatg  ggtccttga  cggaaagaa  tacagatga  ggagagtga  1980
ggactgccc  cagttacag  acgagatgt  ctctgtgcg  cccgtgaca  gaacagtgt  2040
ccagcagtg  aaggggaac  ggcaggcat  agagatcag  acggaacat  ggaggcggg  2100
cctctaaat  acaccggaa  ggaactgaa  tccccacag  cggacggtg  ggacaaatc  2160
ctctctgca  cacatgtct  tctgtgtca  cagggtgaa  tggaaaggc  gaaaactca  2220
gttttggag  ttgagacaa  ccttcatac  gccaaggaa  ctcatgaga  gaatttaag  2280
gagaaagcg  aggaaatta  cagcctaac  cagcttacc  aggagttca  agagagtgc  2340
gaggaagcc  gcagcacgc  cactgctgt  tgtgaagaa  gagaccagc  gctttaccg  2400
gtgaaggag  ttgatgtcc  tggagaact  cgggctcag  tccgagaac  ggaaaccag  2460
cttgcagaa  cagagaagc  aagaggtct  gactatgaa  gtcagaggg  tcagcacaa  2520
ctgctcacc  agcagatcc  cagcctaag  atagaagcc  aatctaaag  tgtgaaaat  2580
gagacttta  aaagagagc  ggatggtgt  caactacaa  tttctgaac  gggaacaca  2640
ataaaaagc  tacagagcc  actgcagac  aaggaaagt  aagtgctag  gggggcaga  2700
cgtatgaag  acatctcaa  agaaatgga  gaactgtcg  aggcgcttt  acagaagga  2760
ctggaaata  cccaaatgg  ccaactctt  ttagagaaa  agaaagatg  ggagacact  2820
cagcaaacc  tccaggaga  ggatcagca  gtgactgaa  tcagcttca  tatgacaga  2880
aaaatggtt  agcttaatg  agagaagtt  tctcttggg  tagaaatta  gactctgaa  2940
gagcagctc  gtttattgt  cagagctga  ggagcaaag  gagagcagg  agaagacag  3000
ggagctgag  ccagcccta  acatggtcc  catgagtcg  gcgcagagg  gccagtgtg  3060
aaagaggca  tacagcaag  acttgagtg  ctgaggaaa  agagtgagc  gaggaagcg  3120
aaactgcag  cagcgctga  cagcagaaa  gagctactg  agaaagtca  caagctgga  3180
gaggagtta  ccaaggtga  agaggagtc  acaaaagac  ccctcaggg  gagtgagaa  3240
agagagctg  aggaagaca  caagaacaa  gatgaccca  aaaagtatg  gacttctga  3300
tggagagaa  tagaggttt  tttaagact  acaatatct  aaaaggaag  ggaactgga  3360
ggcataagg  gggacttaa  agaaaaggc  gcagcagaa  aagagttac  ggccttggt  3420
caacggatg  ctcaggacc  gcagaataa  acaaagcag  tagacttgc  tcaagaaga  3480
atcactgaa  accaagcaa  tattcagaa  ttcatcaca  gcaccatgg  tgctgggga  3540
ggagactca  cagtaaagg  aacctcggt  agcagccca  cccgtgcag  gggtgggga  3600
cactggaag  cggagctgg  gggaaagat  gtagacctg  aaaaagaaa  gactcaact  3660
caaaagaag  ttcaagaag  cttaatttc  cgtaaggca  ttctaaaaa  ggcacaaga  3720
aaagagaaa  atctgaagg  agagctcaa  gagcagaag  atgcttacc  tcacctaca  3780
gaacagttt  atgggcaga  taaggaaaa  gagaacatt  gggccccgc  aaggcaact  3840
caagcaaag  agtctacag  ccagcagct  ccaggcact  gccagcagg  gcccactca  3900
ggttcagaa  gcctttcac  cgaaggcac  gagcctgct  cagagtctg  cttacacgc  3960
gctcagcct  cgcaccctg  agagacagc  actctccag  ctaccgttt  tgttgccca  4020
attcaggac  agctgaaag  aattgaggt  gagaaagaa  agctggaat  gaaaattag  4080
tctacaaca  gtgagctga  caaaaaatc  gaagaagta  tactactac  agaacagat  4140
aatgaacag  gcttagaaa  ccagaattt  aaggcagcg  cccacgaag  caaggccca  4200
acagaacag  tgaagcaag  attggaaag  agccaattg  aaattgctg  cctggaaca  4260
ctgaaaaca  tacagcctg  actagaaac  ctgcaaaag  acgtgggcc  gaaggaaga  4320
gaggtcagc  accttgttg  acagcttgg  gagaaggag  agaccctca  caccgtaca  4380
acagaaatg  aggagcagg  gcgtttaat  aaggccctg  acacacagc  ggaaatgca  4440
gccaaggag  atgaggaga  gctaaagca  gtccaggtg  aaatttgtg  gctaaagaa  4500
cagccaaaa  agcttgagg  agaaagtaa  gcaaaacag  aattacaga  gaaactgca  4560
gctgccctc  tctcccgga  ggaggccct  aaggaaaac  agagtctgc  ggagcagtt  4620
tcctcggcc  gagatgctg  tgaacatct  accaaatct  tggcagatg  agagagcca  4680
gtttctgtt  agaatcaag  gaaagatgc  ctcctagga  agttagccc  tcttcagga  4740
gaaagggac  aactcattg  agaaatgga  aagtcttta  tggaaaatc  gagccttgg  4800
ggctcttgt  aaagcctga  gctagctct  gggggcctc  ctgaagaca  ggaaaagct  4860
atgaaggag  tggaatccg  gagatgttc  aagattgca  agagcaccg  atggcaaga  4920
aagcacaag  agctacaga  agagtatga  gttcttctg  agtcctacg  gaatgtgag  4980
aatgaggca  agaggattc  acacgtggt  gagagcgtg  ggcaagaga  gcaggaggt  5040
tacgcaaag  taaggagcg  agagtcaga  aagagagag  gagagaagc  gctgcagga  5100
gcagaacag  aaatggagg  gatgaagga  aagatgaga  agtttgcca  atctaagca  5160
cagaagatc  ttgagctag  ggaagaaaa  gaccgactt  gagcagagg  ccagcctgt  5220
ggaggagcc  atgaaagca  ggaagctct  ctttcttcc  atgccagct  aaaggagga  5280
ctagaaagg  tcacattgg  gtataaaac  ctttctaag  aatttgagg  tttaatggc  5340
gagaagaac  ctctgagtg  agagactcg  aatctgaag  ttcaggtag  agctcagga  5400
ctgaaacaa  ctagcctcg  gaccaccga  aagtctgat  agccaaagg  tgtcatcga  5460
gaggtaaca  aagccgtgg  aggcaagtc  caagaacaa  attccctga  tgaaaatgc  5520
aagcttgaa  atgcagaag  tactctctt  gctaacagt  ccaagcctg  tgtcagtga  5580
actttcagc  cacacgatg  catcaataa  tacctccag  agcttgatc  gcttaaagg  5640
agaattgct  agttagaga  ggagaaaca  aaagacagg  agcttagcc  gactttgga  5700
aatgaaaaa  atgccctac  gactcagat  tctgcaaag  atagtgagc  caagctcct  5760
gaggaagag  ttgccaaaa  aaacatgct  aatcagcaa  tccaagagg  gctctccag  5820
gtcaccaag  tgaaagaga  agcagagga  gagaaagat  acttagaag  gaggctgat  5880
aatcaactg  cggaactta  tgggagcat  gggaattat  accaggatg  tacagacgc  5940
caaataaag  acgagcaac  agagtcaga  atgcagaac  ttaaaagat  tgtgagtga  6000
ttagaagaa  aaaagcagc  gctggtcaa  gaaaaaacc  aggtggagt  agaaatacg  6060
aaagagtac  tggaaaaga  acaaggtgc  cagaaggga  ctggcagta  aatccacgc  6120
aaagagcta  aggagctgc  caaggaaaa  cagcaagaa  tgaagcaac  gcagaagga  6180
tgcatccgg  acctcggca  gatcagtgc  ctggagaag  ccgtcaagg  cctcgagtt  6240
gttcacact  aatcccaaa  ggatttgga  gcaaccaaa  gaaatctgg  tcaggccgt  6300
gaacaccac  agaaggcac  ggccgagtt  tccagcttc  agatactgc  agatgacac  6360
caaagcgaa  cagcaagag  gctagcgga  aacctcaag  tgaaaaagg  gcttcagtc  6420
aacaaagag  ccatcaaaa  ccagataaa  caaaaagac  aagacctct  gcgaagact  6480
gagcaagca  aagagaaac  ccgaaaaga  aagaagaac  tgcaagaga  gctggatgc  6540
ttgcacaga  aaaaagccc  tgtggaaga  acgcttgcc  agattcaag  cagtctgac  6600
aggaaagac  aggacatga  ggagctgca  caaagcctg  acagcacct  ggcccagct  6660
gcggccttc  ctaagagca  gtcgtccct  caggatgac  gggacaggg  gatcgatga  6720
gccaagaaa  gggagcaga  gttcggtga  gccattcag  ccaaagagg  ggaggtcag  6780
ctcaaagag  agaactgca  tgctctaaa  gatcagctc  gacaaatga  catccacat  6840
gaggaactg  agatcaccg  gtccaggct  gaacatgac  aggaaattt  ggagtccaa  6900
gcccagacc  agctccagc  tcaacagaa  gcttatgat  agctgcaag  agaaaataa  6960
gaacttatg  cacagttag  agaagctgg  cagctgtac  atgattcta  gaatgaatt  7020
actaagttg  aatcagaac  taagagtct  aaagaccaa  caactgact  aaagaactc  7080
ttagaaaaa  gcagagaac  cgaaaacaa  ttggaaggg  tcatcaagc  gcaagaagc  7140
gacatccag  attgtaagt  caattgtga  caactagag  ctgacctga  agcctccag  7200
gagctaacc  ctcggctgc  tgatgaaat  aatgtgaag  aacagaaga  tataagcct  7260
ctttctggc  aggaagagg  gatccaagt  gctatcgca  aactgcacc  acagcacag  7320
aaagagatc  aagaattag  aaacctgtt  tcccaggag  aagaggaga  tttgacctt  7380
gaagaggaa  acaaaaggg  tgttgagaa  accaaccag  tcacagaag  actagaaac  7440
atcaagaag  agagccttg  gcagaaggc  cagttggat  cctttgtta  gtccatgtc  7500
tctcttcag  acgaccggg  ccgcatagt  agtgactac  gacagctgg  agagcggca  7560
ctttctgtg  tcttggaaa  ggacgagct  atccaagat  ctgctgctg  gaataataa  7620
ctgaaggag  agattcgag  gctgcgagg  cacatggat  acctcaact  tgagaatgc  7680
aagctggat  ctgaactga  ccagtatag  cgggacctg  atgaagtga  caccataaa  7740
gactcgcag  aaaggcagc  ccttgaggc  cagctgcag  agaacaaag  gctgagaaa  7800
gagtgtgta  agctagaag  aaggctgaa  gggtcagag  cagagaagc  gagcctgca  7860
atgtccttg  acgccctcc  ggaggagaa  caaggtttg  ctaaagaga  caaaagctt  7920
aaggagcag  tgacggcct  gcacgagga  ggtgcccta  ctgtctacc  tgcccaact  7980
agagtaaga  aggaagaag  tcagaagtt  actgcggct  tctcctcct  tcagaagag  8040
actgtggat  tgcaagagg  gttggtttg  gtccagaag  aggcaagca  gaaggtgag  8100
gagattgaa  ataagctga  gagggagct  aagcatctc  atcacaacg  agggataat  8160
cggaacgaa  cagagacag  agaagagag  gtggcagag  tggccagag  cctcgtcga  8220
atggaacag  agttgctta  ggtaaccaa  gagaataag  atcttacgg  acagattca  8280
gccttcgga  agtcgatga  ttccttgca  gacagcaga  atcatgcca  tgaggagct  8340
agtgacctg  agaagaagt  tgatgccag  ctgaaagag  tggctcagc  gaaagggcg  8400
caggactta  gcagagaga  tgacgttct  tcccaggct  cctttcccc  gaccacctc  8460
gaaaacatc  cgtcccgcc  tgagaaact  aaccagcag  tcatatcca  agacgagca  8520
ttgcttcac  tatcttcag  actagaaag  tctcacaac  aagtgcagt  cttcaccaa  8580
gccatgacc  gcctacaga  tgagagaga  cacctgtgg  atgagctgg  gaaattccg  8640
aagtcggag  aagggaagc  gaggtctgc  gccccttca  ctgcctcca  cccagcaga  8700
gtacagagc  tgaaaaaag  catgtcttc  ctccagaat  acagagatc  attgctgaa  8760
gaactgaag  atctacaac  gcagtactt  cagatgaac  aagagatca  cgagctccg  8820
ccgctgaag  ctcagcttc  ggaatctca  gatcagacc  aagccctgc  gatgatgaa  8880
gaggagctc  ggcaggaaa  cctctcctg  cagcacgag  tcgatcagc  cagagtgga  8940
aagaactct  gggagctgc  tgagagaag  atgaaggaa  agtacctta  ggccatctc  9000
gataaagat  agcagcttg  ccacctgca  aatctcctg  gggaactga  gtcttcctc  9060
cagactcag  ttctcccca  acagtacca  cgacaggcg  cctcaggga  atcagctgc  9120
ctcgacggg  cacaaaacc  agtttatga  acagactgt  tcaggaccc  gctcaatga  9180
agcttaaag  aaatccatc  gaaggagct  agaattcag  aactgaaca  caagttctc  9240
cagctgctt  aggagaaga  catcctctc  acccagctc  gggacgcca  ccagagtct  9300
cgtgacagc  agcatcact  cagtaacct  ttcaaccac  gtgccatcc  ggagaggca  9360
gtgcagcag  tgcaggcta  ggggccact  aatgcagat  ttgctccag  agcacccca  9420
gaaaaggat  ggattcaca  aaagactga  actgagacc  caggggagg  acagccaag  9480
ttttctgaa  tccagcagc  gctgtgcaa  actaaacac  atctgagcg  gctaaagaa  9540
ctgctggaa  aagagcgag  ccaaagact  accgccgaa  atgcactct  cctggccaa  9600
gagcagatc  gacggttgg  gcatagcga  tgggagtca  cccggaccc  aatcattgg  9660
gcctgtggc  ctcaggagc  ggtgctgtt  atggatctc  caggcagta  ctgtcggag  9720
acccggagc  gtgctggat  gaagcgggt  ctgcgttct  tctgccgtt  ccggacccg  9780
gtgccactg  tcgcagcca  ctacttcct  atgattcat  ttttactgg  tctgtgttt  9840
acgggtcac  tataaactt  ttacttgac  actctcgca  ttgtaattc  ttatctgta  9900
tgtcaggat  gttgatccc  gggcggcct  tcgctttga  cccaccctc  tggaaagtg  9960
ctgtgaaaa  aggtggctg  gaggacagg  ggcggtaag  tggcctgcc  catccgctc  10020
ccttaaaca  gtcggcttc  gagatgtgc  gtgttcact  cttcttcag  tgatgcaga  10080
ccacatccc  tgtggcctt  caggatgct  agagaggct  tctagccgt  ccaacaaga  10140
ggttccaat  aacacagta  tctggaatcc  10170



<210> 1874
<211> 3187
<212> PRT
<213> Rattus norvegicus
<308> BAA05026
<400> 1874

Met Leu Ser Arg Leu Ser Gly Leu Ala Asn Asn Val Leu His Glu Leu 
  1               5                  10                  15
Ser Gly Asp Tyr Thr Gly Trp Thr Thr Met Thr Ser Ser Glu Ala Glu 
             20                  25                  30
Leu Pro Gln Gly Ser Ala Met Glu Leu Asn Asn Ser Thr Gln Lys Asp 
         35                  40                  45
Val Leu Asp Arg Leu Ala Asp Ala Glu Lys Leu Val Leu Glu Leu Lys 
     50                  55                  60
Asp Ile Ile Ser Lys Gln Asp Ala Gln Leu Gln Gln Lys Asp Glu Ala 
 65                  70                  75                  80
Leu Gln Glu Glu Lys Lys Gly Ala Glu Ser Lys Ile Lys Lys Ile Lys 
                 85                  90                  95
Leu His Ala Lys Ala Lys Ile Thr Ser Leu Asn Lys Gln Ile Glu Glu 
             100                105                110
Leu Lys Thr Gln Gly Gly Ala Ala Ser Pro Pro Glu Val Gln Ala Glu 
         115                120                125
Glu Leu Ser Lys His Asp Lys Ser Ser Thr Glu Glu Glu Met Glu Val 
     130                135                140
Glu Lys Ile Lys His Glu Leu Gln Glu Lys Glu Lys Leu Ile Ser Asn 
 145                150                155                160
Leu Gln Ala Gln Leu Asp Gln Ala Gln Ser Glu Gln Ala Ser Gln Leu 
                 165                170                175
Asp Lys Ser Ser Ala Glu Met Glu Asp Phe Ile Leu Met Arg Gln Lys 
             180                185                190
Leu Gln Glu Lys Glu Glu Leu Ile Gly Ala Leu Gln Thr Gln Leu Ser 
         195                200                205
Gln Thr Gln Ala Glu Gln Ala Ala Gln Lys Leu Arg Val Met Gln Arg 
     210                215                220
Lys Leu Glu Glu His Glu Glu Ala Leu Leu Gly Arg Ala Gln Val Val 
 225                230                235                240
Asp Leu Leu Gln Lys Glu Leu Thr Ser Ala Glu Gln Arg Asn Gln Asp 
                 245                250                255
Leu Ser Gln Gln Leu Gln Leu Leu Glu Ala Glu His Ser Thr Leu Arg 
             260                265                270
Asn Thr Met Glu Ala Glu Arg Gln Glu Ser Lys Ile Leu Met Glu Lys 
         275                280                285
Val Glu Leu Glu Met Ala Glu Arg Lys Glu Glu Leu Tyr Gln Leu Gln 
     290                295                300
Gly Gln Leu Glu Arg Ala Gly Gln Ala Gln Ala Glu Leu Glu Met Gln 
 305                310                315                320
Tyr Gly Thr Leu Gln Gln Arg His Glu Thr Glu Met Glu Glu Lys Thr 
                 325                330                335
Ala Cys Ile Ser Leu Leu Gln Lys Asn Glu Gln Glu Leu Gln Ser Ala 
             340                345                350
Cys Asp Ala Leu Lys Glu Glu Asn Ser Lys Leu Leu Gln Glu Gln Gln 
         355                360                365
Glu Gln Ala Ala Lys Ser Ala Gln Ala Leu Gln Gln Leu Glu Asp Glu 
     370                375                380
Leu Gln Gln Lys Ser Lys Glu Ile Ser Gln Phe Val Asn Lys Pro Asn 
 385                390                395                400
Leu Glu Lys His Glu Thr Ser Ser Gln Thr Ser Leu Pro Asp Val Tyr 
                 405                410                415
Asn Glu Gly Val Gln Ala Val Met Glu Glu Ser Val Ala Ser Leu Gln 
             420                425                430
Lys Arg Val Leu Glu Leu Glu Asn Glu Lys Gly Ala Leu Leu Leu Ser 
         435                440                445
Ser Leu Glu Leu Glu Glu Leu Arg Ala Glu Asn Glu Lys Leu Cys Ser 
     450                455                460
Arg Ile Thr Leu Leu Glu Ala Gln Asn Arg Ala Gly Glu Ala Asp Gly 
 465                470                475                480
Met Val Cys Glu Val Ser Thr Ala Gly Ile Ala Leu Leu Asn Arg Ser 
                 485                490                495
Asp Ser Ser Thr Glu Glu Ser Gly Gln Asp Val Leu Glu Asn Thr Phe 
             500                505                510
Ser Gln Lys His Lys Glu Leu Ser Val Leu Leu Val Glu Met Lys Glu 
         515                520                525
Ala Gln Glu Glu Ile Ala Phe Leu Lys Ser Gln Leu Gln Gly Lys Arg 
     530                535                540
Pro Glu Gly Asp Tyr Glu Val Leu Asp Arg Lys Glu Val Gln Met Met 
 545                550                555                560
Glu Ser Glu Gly Leu Pro Ser Val Thr Ala Arg Asp Val Leu Cys Ala 
                 565                570                575
Pro Arg Asp Lys Asn Ser Val Pro Ala Val Glu Gly Glu Gln Ala Gly 
             580                585                590
Met Arg Asp Gln His Gly Thr Leu Glu Ala Gly Pro Leu Asn Asp Thr 
         595                600                605
Gly Met Glu Leu Asn Ser Pro Gln Pro Asp Gly Val Asp Lys Ser Leu 
     610                615                620
Ser Ala Pro His Val Cys Leu Cys His Gln Gly Glu Leu Glu Arg Leu 
 625                630                635                640
Lys Thr Gln Val Leu Glu Leu Glu Thr Ser Leu His Thr Ala Lys Glu 
                 645                650                655
Thr His Glu Lys Asn Leu Ser Glu Lys Ala Lys Glu Ile Ser Ser Leu 
             660                665                670
Thr Gln Leu Thr Lys Glu Phe Lys Glu Ser Ala Glu Glu Ala Arg Ser 
         675                680                685
Thr Leu Thr Ala Val Cys Glu Glu Arg Asp Gln Leu Leu Tyr Arg Val 
     690                695                700
Lys Glu Leu Asp Val Leu Gly Glu Leu Arg Ala Gln Val Arg Glu Leu 
 705                710                715                720
Glu Thr Ser Leu Ala Glu Ala Glu Lys Gln Arg Gly Leu Asp Tyr Glu 
                 725                730                735
Ser Gln Arg Ala Gln His Asn Leu Leu Thr Glu Gln Ile His Ser Leu 
             740                745                750
Ser Ile Glu Ala Lys Ser Lys Asp Val Lys Ile Glu Thr Leu Gln Arg 
         755                760                765
Glu Leu Asp Gly Val Gln Leu Gln Phe Ser Glu Gln Gly Thr Gln Ile 
     770                775                780
Lys Ser Leu Gln Ser Gln Leu Gln Thr Lys Glu Ser Glu Val Leu Glu 
 785                790                795                800
Gly Ala Glu Arg Met Lys Asp Ile Ser Lys Glu Met Glu Glu Leu Ser 
                 805                810                815
Gln Ala Leu Ser Gln Lys Glu Leu Glu Ile Ala Gln Met Asp Gln Leu 
             820                825                830
Leu Leu Glu Lys Lys Lys Asp Val Glu Thr Leu Gln Gln Thr Ile Gln 
         835                840                845
Glu Lys Asp Gln Gln Val Thr Glu Leu Ser Phe Ser Met Thr Glu Lys 
     850                855                860
Met Val Gln Leu Asn Glu Glu Lys Phe Ser Leu Gly Val Glu Ile Lys 
 865                870                875                880
Thr Leu Lys Glu Gln Leu Ser Leu Leu Ser Arg Ala Glu Gly Ala Lys 
                 885                890                895
Arg Glu Gln Val Glu Asp Ser Gly Ala Glu Ser Ser Pro Lys His Gly 
             900                905                910
Pro His Glu Ser Ser Ala Glu Glu Pro Val Cys Lys Glu Ala Leu Gln 
         915                920                925
Gln Glu Leu Glu Trp Leu Arg Lys Glu Ser Glu Gln Arg Lys Arg Lys 
     930                935                940
Leu Gln Ala Ala Leu Ile Ser Arg Lys Glu Leu Leu Gln Lys Val Ser 
 945                950                955                960
Lys Leu Glu Glu Glu Leu Ala Lys Val Arg Glu Glu Ser Thr Lys Asp 
                 965                970                975
Ser Leu Arg Glu Ser Glu Lys Arg Glu Leu Glu Glu Asp Ser Lys Asn 
             980                985                990
Lys Asp Asp Pro Glu Lys Tyr Gly Thr Ser Glu Trp Arg Glu Leu Glu 
         995                1000                1005
Val Ser Leu Arg Leu Thr Ile Ser Glu Lys Glu Val Glu Leu Glu Gly 
     1010                1015                1020
Ile Arg Arg Asp Leu Lys Glu Lys Ala Ala Ala Glu Glu Glu Leu Gln 
 1025                1030                1035                1040
Ala Leu Val Gln Arg Met Thr Gln Asp Leu Gln Asn Lys Thr Lys Gln 
                 1045                1050                1055
Ile Asp Leu Leu Gln Glu Glu Ile Thr Glu Asn Gln Ala Thr Ile Gln 
             1060                1065                1070
Lys Phe Ile Thr Gly Thr Met Asp Ala Gly Asp Gly Asp Ser Ala Val 
         1075                1080                1085
Lys Glu Thr Ser Val Ser Ser Pro Pro Arg Ala Gly Gly Gly Glu His 
     1090                1095                1100
Trp Lys Pro Glu Leu Glu Gly Lys Ile Val Asp Leu Glu Lys Glu Lys 
 1105                1110                1115                1120
Thr Gln Leu Gln Lys Lys Leu Gln Glu Ala Leu Ile Ser Arg Lys Ala 
                 1125                1130                1135
Ile Leu Lys Lys Ala Gln Glu Lys Glu Lys His Leu Lys Glu Glu Leu 
             1140                1145                1150
Lys Glu Gln Lys Asp Ala Tyr Arg His Leu Gln Glu Gln Phe Asp Gly 
         1155                1160                1165
Gln Ser Lys Glu Asn Glu Asn Ile Arg Ala Pro Leu Arg Gln Leu Gln 
     1170                1175                1180
Ala Lys Glu Ser Thr Asp Gln Gln Leu Pro Gly Thr Gly Gln Gln Glu 
 1185                1190                1195                1200
Pro Thr His Gly Ser Glu Gly Leu Ser Leu Glu Gly Thr Glu Pro Ala 
                 1205                1210                1215
Ser Glu Ser Asp Leu His Ala Ala Gln Pro Ser His Pro Gly Glu Thr 
             1220                1225                1230
Ala Thr Leu Gln Ala Thr Val Ser Val Ala Gln Ile Gln Asp Gln Leu 
         1235                1240                1245
Lys Glu Ile Glu Val Glu Lys Glu Glu Leu Glu Leu Lys Ile Ser Ser 
     1250                1255                1260
Thr Thr Ser Glu Leu Thr Lys Lys Ser Glu Glu Val Leu Leu Leu Gln 
 1265                1270                1275                1280
Glu Gln Ile Asn Glu Gln Gly Leu Glu Ile Gln Asn Leu Lys Ala Ala 
                 1285                1290                1295
Ser His Glu Ala Lys Ala His Thr Glu Gln Leu Lys Gln Glu Leu Glu 
             1300                1305                1310
Ser Ser Gln Leu Lys Ile Ala Asp Leu Glu His Leu Lys Thr Leu Gln 
         1315                1320                1325
Pro Glu Leu Glu Thr Leu Gln Lys His Val Gly Gln Lys Glu Glu Glu 
     1330                1335                1340
Val Ser Tyr Leu Val Gly Gln Leu Gly Glu Lys Glu Gln Thr Leu Thr 
 1345                1350                1355                1360
Thr Val Gln Thr Glu Met Glu Glu Gln Glu Arg Leu Ile Lys Ala Leu 
                 1365                1370                1375
His Thr Gln Leu Glu Met Gln Ala Lys Glu His Glu Glu Arg Leu Lys 
             1380                1385                1390
Gln Val Gln Val Glu Ile Cys Glu Leu Lys Lys Gln Pro Lys Glu Leu 
         1395                1400                1405
Glu Glu Glu Ser Lys Ala Lys Gln Gln Leu Gln Arg Lys Leu Gln Ala 
     1410                1415                1420
Ala Leu Ile Ser Arg Lys Glu Ala Leu Lys Glu Asn Lys Ser Leu Gln 
 1425                1430                1435                1440
Glu Gln Leu Ser Ser Ala Arg Asp Ala Val Glu His Leu Thr Lys Ser 
                 1445                1450                1455
Leu Ala Asp Val Glu Ser Gln Val Ser Val Gln Asn Gln Glu Lys Asp 
             1460                1465                1470
Ala Leu Leu Gly Lys Leu Ala Leu Leu Gln Glu Glu Arg Asp Lys Leu 
         1475                1480                1485
Ile Val Glu Met Asp Lys Ser Leu Leu Glu Asn Gln Ser Leu Gly Gly 
     1490                1495                1500
Ser Cys Glu Ser Leu Lys Leu Ala Leu Gly Gly Leu Thr Glu Asp Lys 
 1505                1510                1515                1520
Glu Lys Leu Met Lys Glu Leu Glu Ser Val Arg Cys Ser Lys Ile Ala 
                 1525                1530                1535
Glu Ser Thr Glu Trp Gln Glu Lys His Lys Glu Leu Gln Lys Glu Tyr 
             1540                1545                1550
Glu Val Leu Leu Gln Ser Tyr Glu Asn Val Ser Asn Glu Ala Glu Arg 
         1555                1560                1565
Ile Gln His Val Val Glu Ser Val Arg Gln Glu Lys Gln Glu Val Tyr 
     1570                1575                1580
Ala Lys Leu Arg Ser Ala Glu Ser Asp Lys Arg Glu Arg Glu Lys Gln 
 1585                1590                1595                1600
Leu Gln Asp Ala Glu Gln Glu Met Glu Glu Met Lys Glu Lys Met Arg 
                 1605                1610                1615
Lys Phe Ala Lys Ser Lys Gln Gln Lys Ile Leu Glu Leu Glu Glu Glu 
             1620                1625                1630
Asn Asp Arg Leu Arg Ala Glu Ala Gln Pro Val Gly Gly Ala Asn Glu 
         1635                1640                1645
Ser Met Glu Ala Leu Leu Ser Ser Asn Ala Ser Leu Lys Glu Glu Leu 
     1650                1655                1660
Glu Arg Ile Thr Leu Glu Tyr Lys Thr Leu Ser Lys Glu Phe Glu Ala 
 1665                1670                1675                1680
Leu Met Ala Glu Lys Asn Thr Leu Ser Glu Glu Thr Arg Asn Leu Lys 
                 1685                1690                1695
Leu Gln Val Glu Ala Gln Glu Leu Lys Gln Ala Ser Leu Glu Thr Thr 
             1700                1705                1710
Glu Lys Ser Asp Glu Pro Lys Asp Val Ile Glu Glu Val Thr Glu Ala 
         1715                1720                1725
Val Val Gly Lys Ser Gln Glu Gln Asp Ser Leu Ser Glu Asn Ala Lys 
     1730                1735                1740
Leu Glu Asp Ala Glu Ala Thr Leu Leu Ala Asn Ser Ala Lys Pro Gly 
 1745                1750                1755                1760
Val Ser Glu Thr Phe Ser Ser His Asp Asp Ile Asn Asn Tyr Leu Gln 
                 1765                1770                1775
Gln Leu Asp Gln Leu Lys Gly Arg Ile Ala Glu Leu Glu Met Glu Lys 
             1780                1785                1790
Gln Lys Asp Arg Glu Leu Ser Gln Thr Leu Glu Asn Glu Lys Asn Ala 
         1795                1800                1805
Leu Leu Thr Gln Ile Ser Ala Lys Asp Ser Glu Leu Lys Leu Leu Glu 
     1810                1815                1820
Glu Glu Val Ala Lys Ile Asn Met Leu Asn Gln Gln Ile Gln Glu Glu 
 1825                1830                1835                1840
Leu Ser Arg Val Thr Lys Leu Lys Glu Thr Ala Glu Glu Glu Lys Asp 
                 1845                1850                1855
Asp Leu Glu Glu Arg Leu Met Asn Gln Leu Ala Glu Leu Asn Gly Ser 
             1860                1865                1870
Ile Gly Asn Tyr Tyr Gln Asp Val Thr Asp Ala Gln Ile Lys Asn Glu 
         1875                1880                1885
Gln Leu Glu Ser Glu Met Gln Asn Leu Lys Arg Cys Val Ser Glu Leu 
     1890                1895                1900
Glu Glu Glu Lys Gln Gln Leu Val Lys Glu Lys Thr Lys Val Glu Ser 
 1905                1910                1915                1920
Glu Ile Arg Lys Glu Tyr Met Glu Lys Ile Gln Gly Ala Gln Lys Gly 
                 1925                1930                1935
Pro Gly Ser Lys Ile His Ala Lys Glu Leu Gln Glu Leu Leu Lys Glu 
             1940                1945                1950
Lys Gln Gln Glu Val Lys Gln Leu Gln Lys Asp Cys Ile Arg Tyr Leu 
         1955                1960                1965
Gly Arg Ile Ser Ala Leu Glu Lys Thr Val Lys Ala Leu Glu Phe Val 
     1970                1975                1980
His Thr Glu Ser Gln Lys Asp Leu Asp Ala Thr Lys Gly Asn Leu Ala 
 1985                1990                1995                2000
Gln Ala Val Glu His His Lys Lys Ala Gln Ala Glu Leu Ser Ser Phe 
                 2005                2010                2015
Lys Ile Leu Leu Asp Asp Thr Gln Ser Glu Ala Ala Arg Val Leu Ala 
             2020                2025                2030
Asp Asn Leu Lys Leu Lys Lys Glu Leu Gln Ser Asn Lys Glu Ser Ile 
         2035                2040                2045
Lys Ser Gln Ile Lys Gln Lys Asp Glu Asp Leu Leu Arg Arg Leu Glu 
     2050                2055                2060
Gln Ala Glu Glu Lys His Arg Lys Glu Lys Lys Asn Met Gln Glu Lys 
 2065                2070                2075                2080
Leu Asp Ala Leu His Arg Glu Lys Ala His Val Glu Asp Thr Leu Ala 
                 2085                2090                2095
Glu Ile Gln Val Ser Leu Thr Arg Lys Asp Lys Asp Met Lys Glu Leu 
             2100                2105                2110
Gln Gln Ser Leu Asp Ser Thr Leu Ala Gln Leu Ala Ala Phe Thr Lys 
         2115                2120                2125
Ser Met Ser Ser Leu Gln Asp Asp Arg Asp Arg Val Ile Asp Glu Ala 
     2130                2135                2140
Lys Lys Trp Glu Gln Arg Phe Gly Asp Ala Ile Gln Thr Lys Glu Glu 
 2145                2150                2155                2160
Glu Val Arg Leu Lys Glu Glu Asn Cys Thr Ala Leu Lys Asp Gln Leu 
                 2165                2170                2175
Arg Gln Met Thr Ile His Met Glu Glu Leu Lys Ile Thr Val Ser Arg 
             2180                2185                2190
Leu Glu His Asp Lys Glu Ile Trp Glu Ser Lys Ala Gln Thr Glu Leu 
         2195                2200                2205
Gln His Gln Gln Lys Ala Tyr Asp Lys Leu Gln Glu Glu Asn Lys Glu 
     2210                2215                2220
Leu Met Ser Gln Leu Glu Glu Ala Gly Gln Leu Tyr His Asp Ser Lys 
 2225                2230                2235                2240
Asn Glu Leu Thr Lys Leu Glu Ser Glu Leu Lys Ser Leu Lys Asp Gln 
                 2245                2250                2255
Ser Thr Asp Leu Lys Asn Ser Leu Glu Lys Cys Arg Glu His Glu Asn 
             2260                2265                2270
Asn Leu Glu Gly Ile Ile Lys Gln Gln Glu Ala Asp Ile Gln Asn Cys 
         2275                2280                2285
Lys Phe Asn Cys Glu Gln Leu Glu Thr Asp Leu Thr Ala Ser Arg Glu 
     2290                2295                2300
Leu Thr Thr Arg Leu His Asp Glu Ile Asn Val Lys Glu Gln Lys Ile 
 2305                2310                2315                2320
Ile Ser Leu Leu Ser Gly Lys Glu Glu Ala Ile Gln Val Ala Ile Ala 
                 2325                2330                2335
Glu Leu His Gln Gln His Ser Lys Glu Ile Lys Glu Leu Glu Asn Leu 
             2340                2345                2350
Leu Ser Gln Glu Glu Glu Glu Asn Leu Thr Leu Glu Glu Glu Asn Lys 
         2355                2360                2365
Arg Ala Val Glu Lys Thr Asn Gln Leu Thr Glu Ala Leu Glu Thr Ile 
     2370                2375                2380
Lys Lys Glu Ser Leu Glu Gln Lys Ala Gln Leu Asp Ser Phe Val Lys 
 2385                2390                2395                2400
Ser Met Ser Ser Leu Gln Asp Asp Arg Asp Arg Ile Val Ser Asp Tyr 
                 2405                2410                2415
Arg Gln Leu Glu Glu Arg His Leu Ser Val Ile Leu Glu Lys Asp Glu 
             2420                2425                2430
Leu Ile Gln Asp Ala Ala Ala Glu Asn Asn Lys Leu Lys Glu Glu Ile 
         2435                2440                2445
Arg Gly Leu Arg Gly His Met Asp Asp Leu Asn Ser Glu Asn Ala Lys 
     2450                2455                2460
Leu Asp Ala Glu Leu Ile Gln Tyr Arg Arg Asp Leu Asn Glu Val Ile 
 2465                2470                2475                2480
Thr Ile Lys Asp Ser Gln Gln Arg Gln Leu Leu Glu Ala Gln Leu Gln 
                 2485                2490                2495
Gln Asn Lys Glu Leu Arg Asn Glu Cys Val Lys Leu Glu Gly Arg Leu 
             2500                2505                2510
Lys Gly Ser Glu Ala Glu Lys Gln Ser Leu Gln Met Ser Leu Asp Ala 
         2515                2520                2525
Leu Gln Glu Glu Asn Gln Gly Leu Ser Lys Glu Ile Lys Ser Phe Lys 
     2530                2535                2540
Glu Gln Leu Thr Ala Leu His Glu Glu Gly Ala Leu Ala Val Tyr His 
 2545                2550                2555                2560
Ala Gln Leu Arg Val Arg Glu Glu Glu Val Gln Lys Leu Thr Ala Ala 
                 2565                2570                2575
Leu Ser Ser Ser Gln Lys Arg Thr Val Asp Leu Gln Glu Glu Leu Val 
             2580                2585                2590
Cys Val Gln Lys Glu Ala Ser Lys Lys Val Ser Glu Ile Glu Asp Lys 
         2595                2600                2605
Leu Lys Arg Glu Leu Lys His Leu His His Asn Ala Gly Ile Met Arg 
     2610                2615                2620
Asn Glu Thr Glu Thr Ala Glu Glu Arg Val Ala Glu Leu Ala Arg Asp 
 2625                2630                2635                2640
Leu Val Glu Met Glu Gln Lys Leu Leu Thr Val Thr Lys Glu Asn Lys 
                 2645                2650                2655
Asp Leu Thr Ala Gln Ile Gln Ala Phe Gly Lys Ser Met Ser Ser Leu 
             2660                2665                2670
Gln Asp Ser Arg Asp His Ala Thr Glu Glu Leu Ser Asp Leu Lys Lys 
         2675                2680                2685
Lys Tyr Asp Ala Ser Leu Lys Glu Leu Ala Gln Leu Lys Gly Arg Gln 
     2690                2695                2700
Asp Leu Gly Arg Glu Ser Asp Val Leu Ser Gln Ala Ala Phe Pro Leu 
 2705                2710                2715                2720
Thr Thr Ser Glu Asn Ile Ser Ser Arg Leu Glu Lys Leu Asn Gln Gln 
                 2725                2730                2735
Leu Ile Ser Lys Asp Glu Gln Leu Leu His Leu Ser Ser Glu Leu Glu 
             2740                2745                2750
Ser Ser His Asn Gln Val Gln Ser Phe Thr Lys Ala Met Thr Ser Leu 
         2755                2760                2765
Gln Asn Glu Arg Asp His Leu Trp Asn Glu Leu Glu Lys Phe Arg Lys 
     2770                2775                2780
Ser Glu Glu Gly Lys Gln Arg Ser Ala Ala Pro Ser Ala Ala Ser Ser 
 2785                2790                2795                2800
Pro Ala Glu Val Gln Ser Leu Lys Lys Ala Met Ser Ser Leu Gln Asn 
                 2805                2810                2815
Asp Arg Asp Arg Leu Leu Lys Glu Leu Lys Asn Leu Gln Gln Gln Tyr 
             2820                2825                2830
Leu Gln Met Asn Gln Glu Ile Thr Glu Leu Arg Pro Leu Lys Ala Gln 
         2835                2840                2845
Leu Gln Glu Ser Gln Asp Gln Thr Lys Ala Leu Gln Met Met Lys Glu 
     2850                2855                2860
Glu Leu Arg Gln Glu Asn Leu Ser Trp Gln His Glu Leu Asp Gln Leu 
 2865                2870                2875                2880
Arg Val Glu Lys Asn Ser Trp Glu Leu His Glu Arg Arg Met Lys Glu 
                 2885                2890                2895
Gln Tyr Leu Met Ala Ile Ser Asp Lys Asp Gln Gln Leu Gly His Leu 
             2900                2905                2910
Gln Asn Leu Leu Arg Glu Leu Arg Ser Ser Ser Gln Thr Gln Ile Leu 
         2915                2920                2925
Pro Thr Gln Tyr Gln Arg Gln Ala Ser Ser Gly Thr Ser Ala Ala Leu 
     2930                2935                2940
Asp Gly Ser Gln Asn Leu Val Tyr Glu Thr Asp Cys Leu Arg Thr Gln 
 2945                2950                2955                2960
Leu Asn Asp Ser Leu Lys Glu Ile His Gln Lys Glu Leu Arg Ile Gln 
                 2965                2970                2975
Gln Leu Asn Ser Lys Phe Ser Gln Leu Leu Glu Glu Lys Asn Ile Leu 
             2980                2985                2990
Ser Thr Gln Leu Arg Asp Ala Asn Gln Ser Leu Arg Asp Ser Gln His 
         2995                3000                3005
His Tyr Ser Asn Leu Phe Asn His Cys Ala Ile Leu Glu Arg Gln Val 
     3010                3015                3020
Gln Gln Leu Gln Ala Thr Gly Pro Leu Asn Ala Asp Val Ala Pro Gly 
 3025                3030                3035                3040
Ala Pro Gln Glu Lys Asp Gly Ile His Ile Lys Thr Glu Thr Glu Thr 
                 3045                3050                3055
Thr Gly Glu Glu Gln Pro Ser Phe Ser Glu Val Gln Gln Gln Leu Cys 
             3060                3065                3070
Asn Thr Lys His Asp Leu Ser Glu Leu Lys Lys Leu Leu Glu Glu Glu 
         3075                3080                3085
Arg Asp Gln Arg Leu Thr Ala Glu Asn Ala Leu Ser Leu Ala Lys Glu 
     3090                3095                3100
Gln Ile Arg Arg Leu Glu His Ser Glu Trp Glu Ser Ala Arg Thr Pro 
 3105                3110                3115                3120
Ile Ile Gly Ala Cys Gly Ser Gln Glu Gln Val Leu Leu Met Asp Leu 
                 3125                3130                3135
Pro Gly Ser Ser Cys Arg Arg Thr Arg Ser Ser Ala Gly Trp Lys Arg 
             3140                3145                3150
Val Leu Arg Ser Leu Cys Arg Ser Arg Thr Arg Val Pro Leu Leu Ala 
         3155                3160                3165
Ala Ile Tyr Phe Leu Met Ile His Val Leu Leu Val Leu Cys Phe Thr 
     3170                3175                3180
Gly His Leu 
 3185



<210> 1875
<211> 10300
<212> DNA
<213> Homo sapiens
<308> X75304
<400> 1875

aactgctag  ggctgagtc  ctggcgggg  gcggcggtg  aaggtgtcg  gtacgggct  60
cccgagctg  cgtggcttg  attgggagg  gggcagctg  agcctcagg  ggcagcgct  120
ctagaaatg  tgagccgat  atcaggatt  gcaaatgtt  ttttgcatg  attatcagg  180
gatgatgac  ctgatcaga  tatgagggc  cccctagac  ctgaattac  ccaagaatc  240
gacatggaa  ttaataata  tacacaaga  gatgttcag  agcgcctgg  ttatgcaga  300
caattggtg  tggagctaa  agatattat  agacagaag  atgttcaac  gcagcagaa  360
gatgaagct  tacaggaag  gagaaaagc  gctgataac  aaattaaaa  actaaaact  420
catgcgaag  ccaaattaa  ttctttgaa  aaatacata  aagaaatga  agcacaagg  480
gggactgtt  tgcctacag  acctcagtc  gaggagcaa  tttccaagc  tgacaagag  540
tctacagag  aagagatgg  aatagaaaa  ataaaacat  agctccagg  gaaggagga  600
ctaatcagc  ctttgcaag  ccagcttac  caggcacag  cagaacaac  tgcacagag  660
tctacagag  tggaagaat  tgtaatgat  aagcaacag  tccaggaga  ggaagaatt  720
attagcact  tacaagccc  gctcagcca  acacaggca  agcaagctg  acagcaggt  780
gtccgagag  aagatgccc  ctttgaaac  caagttcgt  ttcatgaag  tgagcttct  840
cagttagta  cccaggcag  tgtggaaac  gagatgcaa  agaaattga  ggtgctgca  900
aggaagctt  aggaacacg  agaatcctt  gtgggccgt  ctcaggtcg  tgacttgct  960
caacaggag  tgactgctg  tgagcagag  aaccagatt  tctctcagc  gttacagca  1020
atggaagct  agcataata  tttgaggaa  actgtggaa  cagaaagag  ggagtccaa  1080
attctactg  aaaagatgg  acttgaagt  gcagagaga  aattatcct  ccataatct  1140
caggaagaa  tgcatcatc  tttagaaca  tttgagcaa  caggccaag  ccaggctga  1200
ctagagtct  ggtatagtg  tttggagca  aagcacaaa  cagaaatgg  agagaagac  1260
tctcatatt  tgagtcttc  aaagactgg  caagagctg  agtctgcct  tgatgctct  1320
aaggatcaa  attcaaagc  tctccaaga  aagaatgaa  aggcagttc  gtcagccca  1380
accattcag  aactggaag  tcagctcca  caaaaatcc  aagaaatta  ccaatttct  1440
aatagactg  ccttgcaac  acatgaaac  gcatctcag  cttctttcc  agatgttta  1500
aatgagggc  cacaggcag  cactgagga  aatattgct  ctttgcaga  gagagtggt  1560
gaactagag  atgaaaagg  agccttgct  cttagttct  tagagctgg  ggagctgaa  1620
gctgagaat  aaaaactgt  ttctcagat  actctccta  aggctcaga  tagaactgg  1680
gaggcagac  gagaagtca  tgagatcag  attgttgat  ttgccaaca  gaggagctc  1740
tctgctgag  aaagtggac  agatgttct  gaaaacaca  tttctcaga  acataaaga  1800
ttatcagtt  tattgttgg  aatgaaaga  gctcaagag  aaattgcat  tcttaaatt  1860
cagctccag  gaaaaaggg  tgaggaagc  gatcatgag  tccttgacc  gaaagaaat  1920
aaacagatg  agggtgagg  aatagctcc  attaaaatg  aagtatttc  tgaagatac  1980
gggcaagat  ttcccttaa  gccaaatga  gagagcagt  ttccagcag  tgaaaaaga  2040
caggcgagc  ctgaacatc  aagtagaac  tctgaggaa  tatctttaa  tgatgctgg  2100
gtagaattg  aatcaacaa  gcaggatgg  gataaatcc  tttctgctg  accagatat  2160
ggtcagtgt  atcaggatg  gttggaaag  ttaaaaagt  aaattttgg  gctcgagct  2220
aactttcat  aagcacaag  aatctatga  aaaaattta  atgagaaag  taaggaaat  2280
agcaaccta  accagttga  tgaggagtt  aagaaaaat  ctgacaaca  cagcagtgc  2340
ttcactgct  tgtctgaag  aagagacca  cttctctct  aggtgaagg  acttagcat  2400
gtaacagaa  tgagggctc  ggtaaagca  ctggaaatg  accttgcag  agcagaaag  2460
caaagaaga  ttgattatg  aagccaaac  gcccatgac  acctgctca  tgaacagat  2520
catagtctc  gcatagaag  caaatctaa  gatgtgaaa  ttgaagttt  acagaatga  2580
ctggatgat  tgcagcttc  gttttctga  cagagtacc  tgataagaa  cctgcaaag  2640
cagctgcaa  ataaggaaa  tgaagtgct  gagggggca  aacgtgtaa  gcatatctc  2700
agtaaagtg  aagaactgt  ccaggctct  tcacagaag  aacttgaaa  aacaaaaat  2760
gatcagctc  tactagaga  aaagagaga  gtggaaacc  tccaacaaa  catcgagga  2820
aaggatcaa  aagtgacag  aatcagctt  agtatgact  agaaaatgg  tcagcttaa  2880
gaagagaag  tttctcttg  ggttgaaat  aagactctt  aagaacagc  aaatttatt  2940
tccagagct  aggaagcaa  aaaagagca  gtggaagaa  ataatgaag  ttcttctgg  3000
cttaaacaa  attatgatg  gatgagccc  gcaggacaa  taagtaagg  agaacttca  3060
catgaattt  accttctga  gaaagaaaa  gagcagaga  agagaaagc  ccaggcagc  3120
cttattaac  gaaaggagc  tctgcaaag  gtcagtaga  tggaagaag  attagccaa  3180
ttgaaagat  aatctaaga  agaaatccc  ctcagtgag  ctgagaggg  agaagtgga  3240
gaagataaa  aaaacaaag  atactcaga  aaatgtgtg  cttctaagt  ccaagaaat  3300
gaaatttat  taaaacaga  aatatctga  aaagaagtg  aactacagc  tataaggaa  3360
gatttggaa  aaaagctgg  agctgaaga  caattccag  ctctggtca  acagatgaa  3420
cagaccttg  aagataaaa  aaaccaaat  gatttgctc  aagcagaaa  cagtgaaaa  3480
caagcaatt  tccagaagt  aatcacaag  aacacggat  caagtgatg  ggactccgt  3540
gcacttgta  aggaaacag  ggtgataag  ccaccttgt  caggtagta  tgaacactg  3600
aaaccagaa  tagaagaaa  gatactggc  cttgaaaaa  aaaaggagc  acttcaaaa  3660
aagctacag  aagccttaa  ctcccgcaa  gcaattctt  aaaaggcac  ggagaaaga  3720
agacatctc  gggaggagc  aaagcaaca  aaagatgac  ataatcgct  gcaagaaca  3780
tttgatgag  aaagcaagg  aaatgagaa  attggagac  agctaaggc  actccagat  3840
caagtaagg  aatccatag  cggaaaact  ccaagcaca  accagcagg  atcgtgttc  3900
tccactcca  gtttagaag  acctttatt  aaagccaca  aacagcatc  cactcaacc  3960
gttttagag  ccaacttgt  cccagactg  ccttctcat  ctgaagatg  gagtgctct  4020
cagggcgga  cttctgttg  ccagattaa  gcccagctg  aggaaatag  ggctgagaa  4080
gtagagtta  aattgaaag  tagttctac  acaagtgag  ttactaaaa  atcagaaga  4140
gtatttcag  tacaagagc  gataaataa  cagggttta  aaatcgaga  tctaaagac  4200
gtatcccat  aagctgaag  ccatgccga  agcctgcag  agaaattgg  aagcagcca  4260
ctacaaatt  ctggcctag  acatctaag  gaattgcaa  ctaaactgg  tgaactgca  4320
aaactcata  gcaaaaagg  agaagacgt  agctacctt  ctggacaac  tagtgagaa  4380
gaagcagct  tcactaaaa  acagacaga  ataatagaa  aagaagatt  aattaaggc  4440
ctgcataca  agctagaaa  gcaagccaa  gagcatgat  agaggataa  gcagctaca  4500
gtggaactt  gtgaaatga  gcaaaaacc  gaagagatt  gagaagaaa  tagagcaaa  4560
caacaaata  aaaggaaac  gcaagctgc  cttatttcc  gaaaagaag  actaaaaga  4620
aacaaaagt  tccaagagg  attgtcttt  gccagaggt  ccattgaac  tctcaccaa  4680
tctctggca  atgtggaaa  ccaagtttc  gctcaaaat  aagaaaaag  tacggtctt  4740
ggaaggtta  ctcttcttc  agaagaaag  gacaaactc  ttacagaaa  ggacaggtc  4800
ttattggaa  atcagagtc  cagcagctc  tgtgaaagt  taaaactag  tctagaggg  4860
cttactgaa  acaaggaaa  gttagtgaa  gaaattgaa  ctttgaaat  ttctaagat  4920
gcagaaagt  ctgagtggc  agagaaaca  aaggagcta  aaaaagagt  tgaaattct  4980
ctgcagtcc  atgagaatg  tagtaatga  gcagaaagg  ttcagcatg  ggtggaagc  5040
gtgaggcaa  agaaacaag  actgtatgg  aagttaaga  gcacagagg  aaacaagaa  5100
gagacagaa  agcagttgc  ggaagctga  caagaaatg  aggaaatga  agaaaagat  5160
agaaagttt  ctaaatcta  acagcagaa  atcctagag  tggaagaag  gaatgaccg  5220
cttagggca  aggtgcacc  tgcaggaga  acagctaaa  agtgtatgg  aacacttct  5280
tcttccaat  ccagcatga  ggaagaact  gaaagggtc  aaatggagt  tgaaaccct  5340
tctaagaag  ttcagtctt  aatgtctga  aaagactct  taagtgaag  ggttcaaga  5400
ttaaagcat  agatagaag  taatgtatc  aaacaagct  acctagagg  caccgagaa  5460
catgataac  aaacgaatg  cactgaaga  ggaacacag  ctataccag  tgagactga  5520
gagcaagac  ctctgagta  gagcacaag  cctacatgt  cagaatcgg  tccatcagc  5580
aagagtgcc  accctgctg  aagtaagga  ttcagctca  atgatgaaa  taataacta  5640
ctacagcag  ttgatcagc  caaagaaag  attgctgga  tagaggagg  gaagcagaa  5700
aacaaggaa  ttagccaga  tttagaaaa  gagaaaaat  ccttactga  tcagatatc  5760
acaaaggat  gtgaactaa  aatgcttca  gaggaagta  ccaaaatga  cctgttaaa  5820
cagcaaatc  aagaagaac  ctccagagt  accaaacta  aggagacag  agaagaaga  5880
aaagatgat  tggaagaga  gcttatgaa  caattagca  aacttaatg  aagcattgg  5940
aattactgt  aggatgtta  agatgccca  ataaaaaat  agctattgg  atctgaaat  6000
aagaacctt  aaaagtgtg  gagtgaatt  gaagaagaa  agcagcagt  agtcaagga  6060
aaaactaag  tggaatcag  aatacgaaa  gaatatttg  agaaaatac  aggtgctca  6120
aaagaaccc  gaaataaaa  ccatgcaaa  gaacttcag  aactgttaa  agaaaaaca  6180
caagaagta  agcagctac  gaaggactg  atcaggtat  aagagaaaa  tagtgctct  6240
gagagaact  ttaaagctc  agaatttgt  caaactgaa  ctcaaaaag  tttggaaat  6300
accaaagaa  atctggctc  agcagttga  caccgcaaa  aggcacaag  agaattagc  6360
agcttcaaa  tcctgctag  tgacactca  agtgaagca  caagggtcc  agcagacaa  6420
ctcaagttg  aaaaggaac  tcagtcaaa  aaagaatca  ttaaaagcc  gatgaaaca  6480
aaggatgaa  atcttgagc  aagactgga  caggcagaa  agaagcacc  gaaagagaa  6540
aagaatatg  aagagaaac  ggatgcttt  cgcagagaa  aagtccact  ggaagagac  6600
attggagag  ttcaggtta  tttgaacaa  aaagacaag  aagttcagc  acttcagga  6660
aacttggac  gtactgtga  ccagcttgc  gcctttact  agagcatgt  ttccctcca  6720
gatgatcgt  acagggtga  agatgaagc  aagaaatgg  agaggaagt  tagtgatgc  6780
attcaaagc  aagaagaag  aattagact  aaagaagat  attgcagtg  tctaaagga  6840
caacttaga  agatgtcca  ccatatgga  gaattaaag  ttaacattt  caggcttga  6900
catgacaag  agatttggg  gtccaaggc  cagacagag  tccagcttc  gcagaaggt  6960
tgtgatact  tacaggggg  aaacaaaga  cttttgtcc  agctagaag  gacacgcca  7020
ctataccac  gttctcaga  tgaattagc  aagttggaa  cagaactta  gagtctcaa  7080
gaccagttg  ctgatttaa  taactcttt  gaaaaatgt  aggaacaaa  aggaaactt  7140
gaagggatc  taaggcagc  agaggctga  attcaaaat  ctaagttca  ttatgaaca  7200
ctggagact  atcttcagg  ctccagaga  ctgaccagt  ggctgcatg  agaaataaa  7260
atgaaagag  aaaagatta  aagcctgct  tctggcaag  aagaggcaa  ccaagtagc  7320
attgctgaa  tgcgtcagc  acatgataa  gaaattaaa  agctggaaa  cctgctgtc  7380
caggaggaa  aggagaata  tgttttaga  gaggagaac  aaaaggctg  tgataaaac  7440
aatcagctt  tggaaacac  gaaaaccat  aaaaaggaa  acattcagc  aaaggcaca  7500
ttggattcc  ttgttaaat  catgtcttc  ctccaaaat  atcgagacc  catagtggg  7560
gactatcaa  agctggaag  gcgacatct  tctataatc  tggaaaaag  ccaactcat  7620
caagaggct  ctgcagaga  taataagct  aaagaagaa  tacgaggct  gagaagtca  7680
atggatgat  tcaattctg  gaatgccaa  ctagatgca  aactgatcc  atatagaga  7740
gacctgaac  aagtgataa  aataaagga  agccaacaa  agcagcttc  tgaagttca  7800
cttcagcaa  ataaggagc  ggaaaataa  tatgctaaa  tagaagaaa  gctgaagga  7860
tctgaggaa  caaatgagg  tctgcggag  tcctttaat  ccctacaag  agagaaaca  7920
gatttatct  aagagattg  gagtttgaa  gtatctata  cccagctaa  aagacaagt  7980
acagccttg  aagaagaag  tactttagg  ctctatcat  cccagttaa  agtaaaaga  8040
gaagaggta  acaggttaa  tgctttgtt  tcctcctct  aaaagagaa  tgcagaact  8100
gaagaagaa  tggtttgtg  tcaaaagga  gctgccaag  aggtaggtg  aattgaaga  8160
aaactgaag  aagaattaa  gcatcttca  catgatgca  ggataatga  aaatgaaac  8220
gaaacagca  aagagagag  ggcagagct  gcaagagat  tggtggaga  ggaacagaa  8280
ttactcatg  tcaccaaag  aaataaagg  ctcacagca  aaattcagt  ttttggaag  8340
tctatgagt  ccttgcaaa  tagtagaga  catgccaat  aggaacttg  tgaactgaa  8400
aggaaatat  atgccagtc  gaaggaatt  gcacagttg  aagaacagg  actcttaaa  8460
agagagaga  atgctcttc  ttctgaaac  gccttttca  tgaactcca  tgaggagaa  8520
agcttgtct  accttgaga  acttaacca  cagctccta  ccaaagatg  gcaattgct  8580
cacttgtcc  cacaactag  agattctta  aaccaagtg  agtcctttt  caaggctat  8640
gccagtctg  agaatgaga  agatcacct  tggaatgag  tggagaaat  tcgaaagtc  8700
gaggaaggg  agcagaggt  tgcagctca  ccttccacc  gcccagctg  agtacagag  8760
ttaaaaaaa  ctatgtctt  actccaaaa  gacagagac  gactactga  ggaattgaa  8820
aatctgcag  agcaatact  acagattaa  caagagatc  ctgagttac  tccactgaa  8880
gctcaactt  aggagtatc  agataagac  aaagcattt  agattatgc  agaagagct  8940
aggcaggaa  acctctcct  gcagcatga  ctgcatcag  tcaggatgg  gaagagttc  9000
tgggaaata  atgagagga  aatgaagga  cagtacctt  tggctatct  agataaaga  9060
cagcagctc  gtcatctgc  gaatcttat  agggaattg  ggtcttctt  ctcccagac  9120
cagcctctc  aagtgcaat  ccaaagaca  gcatcccca  agacatcag  ttccccaga  9180
gggtcacaa  atctggttt  tgagacaga  cttctcagg  cccagctca  tgacagctt  9240
aaggaaatt  accaaaagg  gttaagaat  cagcaactg  acagcaact  ctctcagct  9300
ctggaagag  aaaacaccc  ttccattca  ctctgcgat  ccagtcaga  tcttcgtga  9360
aaccagcag  actatggtg  ccttttaaa  cactgtgca  tcttggaga  gcaggttca  9420
gagctgcag  cggggccac  aaatataga  gttgctcca  gagctcccc  ggaaaagaa  9480
ggagttcac  gaaagagtg  ccctgagga  ctaagggaa  cgcagcaaa  cttttctga  9540
gctcagcag  agctatgca  caccagaca  gaagtgaat  aattaagga  gctgctgga  9600
gaagaacga  accaaagag  ggctgctga  aatgctctc  ctgtggccg  ggagcagat  9660
agacggtta  agcacagtg  atgggactc  tcccggact  ctatcattg  ctcctgtgg  9720
actcaggag  aggcactgt  aatagatct  acaagcaac  gttgtcgaa  gacccggag  9780
ggcgttgga  ggaagcgag  cctgcgttc  ctctgtcat  cacggaccc  agtgccact  9840
ctagcagcc  tctactttc  aatgattca  gtcctgctc  ttctgtgtt  tacgggcca  9900
ctatagact  agttgttac  ctttggacc  ctcccttca  aacttggaa  tctctcacc  9960
ctaacatca  aacatcaat  ccagtggaa  agtcttccc  tttacaggt  ttctctcca  10020
ctcttcacg  aaagtgcct  caaaaacag  ggtggatac  aggacaggt  ggagctgca  10080
ggactggcg  gtctgcttt  ttctactgc  ctgagcctg  acgcttctg  ttaatctga  10140
aatcacatt  ggtttgttg  gcctaatat  tgttgagat  ttgcaggac  ctgatcttt  10200
gtggtcctg  aaaagatac  gaggaatgt  tttcagcca  gccaagagg  tggtttcaa  10260
aaacctaat  atctgaagt  cagcttttt  tttttttttt  10300



<210> 1876
<211> 3259
<212> PRT
<213> Homo sapiens
<308> CAA53052
<400> 1876

Met Leu Ser Arg Leu Ser Gly Leu Ala Asn Val Val Leu His Glu Leu 
  1               5                  10                  15
Ser Gly Asp Asp Asp Thr Asp Gln Asn Met Arg Ala Pro Leu Asp Pro 
             20                  25                  30
Glu Leu His Gln Glu Ser Asp Met Glu Phe Asn Asn Thr Thr Gln Glu 
         35                  40                  45
Asp Val Gln Glu Arg Leu Ala Tyr Ala Glu Gln Leu Val Val Glu Leu 
     50                  55                  60
Lys Asp Ile Ile Arg Gln Lys Asp Val Gln Leu Gln Gln Lys Asp Glu 
 65                  70                  75                  80
Ala Leu Gln Glu Glu Arg Lys Ala Ala Asp Asn Lys Ile Lys Lys Leu 
                 85                  90                  95
Lys Leu His Ala Lys Ala Lys Leu Thr Ser Leu Asn Lys Tyr Ile Glu 
             100                105                110
Glu Met Lys Ala Gln Gly Gly Thr Val Leu Pro Thr Glu Pro Gln Ser 
         115                120                125
Glu Glu Gln Leu Ser Lys His Asp Lys Ser Ser Thr Glu Glu Glu Met 
     130                135                140
Glu Ile Glu Lys Ile Lys His Lys Leu Gln Glu Lys Glu Glu Leu Ile 
 145                150                155                160
Ser Thr Leu Gln Ala Gln Leu Thr Gln Ala Gln Ala Glu Gln Pro Ala 
                 165                170                175
Gln Ser Ser Thr Glu Met Glu Glu Phe Val Met Met Lys Gln Gln Leu 
             180                185                190
Gln Glu Lys Glu Glu Phe Ile Ser Thr Leu Gln Ala Gln Leu Ser Gln 
         195                200                205
Thr Gln Ala Glu Gln Ala Ala Gln Gln Val Val Arg Glu Lys Asp Ala 
     210                215                220
Arg Phe Glu Thr Gln Val Arg Leu His Glu Asp Glu Leu Leu Gln Leu 
 225                230                235                240
Val Thr Gln Ala Asp Val Glu Thr Glu Met Gln Gln Lys Leu Arg Val 
                 245                250                255
Leu Gln Arg Lys Leu Glu Glu His Glu Glu Ser Leu Val Gly Arg Ala 
             260                265                270
Gln Val Val Asp Leu Leu Gln Gln Glu Leu Thr Ala Ala Glu Gln Arg 
         275                280                285
Asn Gln Ile Leu Ser Gln Gln Leu Gln Gln Met Glu Ala Glu His Asn 
     290                295                300
Thr Leu Arg Asn Thr Val Glu Thr Glu Arg Glu Glu Ser Lys Ile Leu 
 305                310                315                320
Leu Glu Lys Met Glu Leu Glu Val Ala Glu Arg Lys Leu Ser Phe His 
                 325                330                335
Asn Leu Gln Glu Glu Met His His Leu Leu Glu Gln Phe Glu Gln Ala 
             340                345                350
Gly Gln Ala Gln Ala Glu Leu Glu Ser Arg Tyr Ser Ala Leu Glu Gln 
         355                360                365
Lys His Lys Ala Glu Met Glu Glu Lys Thr Ser His Ile Leu Ser Leu 
     370                375                380
Gln Lys Thr Gly Gln Glu Leu Gln Ser Ala Cys Asp Ala Leu Lys Asp 
 385                390                395                400
Gln Asn Ser Lys Leu Leu Gln Asp Lys Asn Glu Gln Ala Val Gln Ser 
                 405                410                415
Ala Gln Thr Ile Gln Gln Leu Glu Asp Gln Leu Gln Gln Lys Ser Lys 
             420                425                430
Glu Ile Ser Gln Phe Leu Asn Arg Leu Pro Leu Gln Gln His Glu Thr 
         435                440                445
Ala Ser Gln Thr Ser Phe Pro Asp Val Tyr Asn Glu Gly Thr Gln Ala 
     450                455                460
Val Thr Glu Glu Asn Ile Ala Ser Leu Gln Lys Arg Val Val Glu Leu 
 465                470                475                480
Glu Asn Glu Lys Gly Ala Leu Leu Leu Ser Ser Ile Glu Leu Glu Glu 
                 485                490                495
Leu Lys Ala Glu Asn Glu Lys Leu Ser Ser Gln Ile Thr Leu Leu Glu 
             500                505                510
Ala Gln Asn Arg Thr Gly Glu Ala Asp Arg Glu Val Ser Glu Ile Ser 
         515                520                525
Ile Val Asp Ile Ala Asn Lys Arg Ser Ser Ser Ala Glu Glu Ser Gly 
     530                535                540
Gln Asp Val Leu Glu Asn Thr Phe Ser Gln Lys His Lys Glu Leu Ser 
 545                550                555                560
Val Leu Leu Leu Glu Met Lys Glu Ala Gln Glu Glu Ile Ala Phe Leu 
                 565                570                575
Lys Leu Gln Leu Gln Gly Lys Arg Ala Glu Glu Ala Asp His Glu Val 
             580                585                590
Leu Asp Gln Lys Glu Met Lys Gln Met Glu Gly Glu Gly Ile Ala Pro 
         595                600                605
Ile Lys Met Lys Val Phe Leu Glu Asp Thr Gly Gln Asp Phe Pro Leu 
     610                615                620
Met Pro Asn Glu Glu Ser Ser Leu Pro Ala Val Glu Lys Glu Gln Ala 
 625                630                635                640
Ser Thr Glu His Gln Ser Arg Thr Ser Glu Glu Ile Ser Leu Asn Asp 
                 645                650                655
Ala Gly Val Glu Leu Lys Ser Thr Lys Gln Asp Gly Asp Lys Ser Leu 
             660                665                670
Ser Ala Val Pro Asp Ile Gly Gln Cys His Gln Asp Glu Leu Glu Arg 
         675                680                685
Leu Lys Ser Gln Ile Leu Glu Leu Glu Leu Asn Phe His Lys Ala Gln 
     690                695                700
Glu Ile Tyr Glu Lys Asn Leu Asp Glu Lys Ala Lys Glu Ile Ser Asn 
 705                710                715                720
Leu Asn Gln Leu Ile Glu Glu Phe Lys Lys Asn Ala Asp Asn Asn Ser 
                 725                730                735
Ser Ala Phe Thr Ala Leu Ser Glu Glu Arg Asp Gln Leu Leu Ser Gln 
             740                745                750
Val Lys Glu Leu Ser Met Val Thr Glu Leu Arg Ala Gln Val Lys Gln 
         755                760                765
Leu Glu Met Asn Leu Ala Glu Ala Glu Arg Gln Arg Arg Leu Asp Tyr 
     770                775                780
Glu Ser Gln Thr Ala His Asp Asn Leu Leu Thr Glu Gln Ile His Ser 
 785                790                795                800
Leu Ser Ile Glu Ala Lys Ser Lys Asp Val Lys Ile Glu Val Leu Gln 
                 805                810                815
Asn Glu Leu Asp Asp Val Gln Leu Gln Phe Ser Glu Gln Ser Thr Leu 
             820                825                830
Ile Arg Ser Leu Gln Ser Gln Leu Gln Asn Lys Glu Ser Glu Val Leu 
         835                840                845
Glu Gly Ala Glu Arg Val Arg His Ile Ser Ser Lys Val Glu Glu Leu 
     850                855                860
Ser Gln Ala Leu Ser Gln Lys Glu Leu Glu Ile Thr Lys Met Asp Gln 
 865                870                875                880
Leu Leu Leu Glu Lys Lys Arg Asp Val Glu Thr Leu Gln Gln Thr Ile 
                 885                890                895
Glu Glu Lys Asp Gln Gln Val Thr Glu Ile Ser Phe Ser Met Thr Glu 
             900                905                910
Lys Met Val Gln Leu Asn Glu Glu Lys Phe Ser Leu Gly Val Glu Ile 
         915                920                925
Lys Thr Leu Lys Glu Gln Leu Asn Leu Leu Ser Arg Ala Glu Glu Ala 
     930                935                940
Lys Lys Glu Gln Val Glu Glu Asp Asn Glu Val Ser Ser Gly Leu Lys 
 945                950                955                960
Gln Asn Tyr Asp Glu Met Ser Pro Ala Gly Gln Ile Ser Lys Glu Glu 
                 965                970                975
Leu Gln His Glu Phe Asp Leu Leu Lys Lys Glu Asn Glu Gln Arg Lys 
             980                985                990
Arg Lys Leu Gln Ala Ala Leu Ile Asn Arg Lys Glu Leu Leu Gln Arg 
         995                1000                1005
Val Ser Arg Leu Glu Glu Glu Leu Ala Asn Leu Lys Asp Glu Ser Lys 
     1010                1015                1020
Lys Glu Ile Pro Leu Ser Glu Thr Glu Arg Gly Glu Val Glu Glu Asp 
 1025                1030                1035                1040
Lys Glu Asn Lys Glu Tyr Ser Glu Lys Cys Val Thr Ser Lys Cys Gln 
                 1045                1050                1055
Glu Ile Glu Ile Tyr Leu Lys Gln Thr Ile Ser Glu Lys Glu Val Glu 
             1060                1065                1070
Leu Gln His Ile Arg Lys Asp Leu Glu Glu Lys Leu Ala Ala Glu Glu 
         1075                1080                1085
Gln Phe Gln Ala Leu Val Lys Gln Met Asn Gln Thr Leu Gln Asp Lys 
     1090                1095                1100
Thr Asn Gln Ile Asp Leu Leu Gln Ala Glu Ile Ser Glu Asn Gln Ala 
 1105                1110                1115                1120
Ile Ile Gln Lys Leu Ile Thr Ser Asn Thr Asp Ala Ser Asp Gly Asp 
                 1125                1130                1135
Ser Val Ala Leu Val Lys Glu Thr Val Val Ile Ser Pro Pro Cys Thr 
             1140                1145                1150
Gly Ser Ser Glu His Trp Lys Pro Glu Leu Glu Glu Lys Ile Leu Ala 
         1155                1160                1165
Leu Glu Lys Glu Lys Glu Gln Leu Gln Lys Lys Leu Gln Glu Ala Leu 
     1170                1175                1180
Thr Ser Arg Lys Ala Ile Leu Lys Lys Ala Gln Glu Lys Glu Arg His 
 1185                1190                1195                1200
Leu Arg Glu Glu Leu Lys Gln Gln Lys Asp Asp Tyr Asn Arg Leu Gln 
                 1205                1210                1215
Glu Gln Phe Asp Glu Gln Ser Lys Glu Asn Glu Asn Ile Gly Asp Gln 
             1220                1225                1230
Leu Arg Gln Leu Gln Ile Gln Val Arg Glu Ser Ile Asp Gly Lys Leu 
         1235                1240                1245
Pro Ser Thr Asp Gln Gln Glu Ser Cys Ser Ser Thr Pro Gly Leu Glu 
     1250                1255                1260
Glu Pro Leu Phe Lys Ala Thr Glu Gln His His Thr Gln Pro Val Leu 
 1265                1270                1275                1280
Glu Ser Asn Leu Cys Pro Asp Trp Pro Ser His Ser Glu Asp Ala Ser 
                 1285                1290                1295
Ala Leu Gln Gly Gly Thr Ser Val Ala Gln Ile Lys Ala Gln Leu Lys 
             1300                1305                1310
Glu Ile Glu Ala Glu Lys Val Glu Leu Glu Leu Lys Val Ser Ser Thr 
         1315                1320                1325
Thr Ser Glu Leu Thr Lys Lys Ser Glu Glu Val Phe Gln Leu Gln Glu 
     1330                1335                1340
Gln Ile Asn Lys Gln Gly Leu Glu Ile Glu Ser Leu Lys Thr Val Ser 
 1345                1350                1355                1360
His Glu Ala Glu Val His Ala Glu Ser Leu Gln Gln Lys Leu Glu Ser 
                 1365                1370                1375
Ser Gln Leu Gln Ile Ala Gly Leu Glu His Leu Arg Glu Leu Gln Pro 
             1380                1385                1390
Lys Leu Asp Glu Leu Gln Lys Leu Ile Ser Lys Lys Glu Glu Asp Val 
         1395                1400                1405
Ser Tyr Leu Ser Gly Gln Leu Ser Glu Lys Glu Ala Ala Leu Thr Lys 
     1410                1415                1420
Ile Gln Thr Glu Ile Ile Glu Gln Glu Asp Leu Ile Lys Ala Leu His 
 1425                1430                1435                1440
Thr Gln Leu Glu Met Gln Ala Lys Glu His Asp Glu Arg Ile Lys Gln 
                 1445                1450                1455
Leu Gln Val Glu Leu Cys Glu Met Lys Gln Lys Pro Glu Glu Ile Gly 
             1460                1465                1470
Glu Glu Ser Arg Ala Lys Gln Gln Ile Gln Arg Lys Leu Gln Ala Ala 
         1475                1480                1485
Leu Ile Ser Arg Lys Glu Ala Leu Lys Glu Asn Lys Ser Leu Gln Glu 
     1490                1495                1500
Glu Leu Ser Leu Ala Arg Gly Thr Ile Glu Arg Leu Thr Lys Ser Leu 
 1505                1510                1515                1520
Ala Asp Val Glu Ser Gln Val Ser Ala Gln Asn Lys Glu Lys Asp Thr 
                 1525                1530                1535
Val Leu Gly Arg Leu Ala Leu Leu Gln Glu Glu Arg Asp Lys Leu Ile 
             1540                1545                1550
Thr Glu Met Asp Arg Ser Leu Leu Glu Asn Gln Ser Leu Ser Ser Ser 
         1555                1560                1565
Cys Glu Ser Leu Lys Leu Ala Leu Glu Gly Leu Thr Glu Asp Lys Glu 
     1570                1575                1580
Lys Leu Val Lys Glu Ile Glu Ser Leu Lys Ser Ser Lys Ile Ala Glu 
 1585                1590                1595                1600
Ser Thr Glu Trp Gln Glu Lys His Lys Glu Leu Gln Lys Glu Tyr Glu 
                 1605                1610                1615
Ile Leu Leu Gln Ser Tyr Glu Asn Val Ser Asn Glu Ala Glu Arg Ile 
             1620                1625                1630
Gln His Val Val Glu Ala Val Arg Gln Glu Lys Gln Glu Leu Tyr Gly 
         1635                1640                1645
Lys Leu Arg Ser Thr Glu Ala Asn Lys Lys Glu Thr Glu Lys Gln Leu 
     1650                1655                1660
Gln Glu Ala Glu Gln Glu Met Glu Glu Met Lys Glu Lys Met Arg Lys 
 1665                1670                1675                1680
Phe Ala Lys Ser Lys Gln Gln Lys Ile Leu Glu Leu Glu Glu Glu Asn 
                 1685                1690                1695
Asp Arg Leu Arg Ala Glu Val His Pro Ala Gly Asp Thr Ala Lys Glu 
             1700                1705                1710
Cys Met Glu Thr Leu Leu Ser Ser Asn Ala Ser Met Lys Glu Glu Leu 
         1715                1720                1725
Glu Arg Val Lys Met Glu Tyr Glu Thr Leu Ser Lys Lys Phe Gln Ser 
     1730                1735                1740
Leu Met Ser Glu Lys Asp Ser Leu Ser Glu Glu Val Gln Asp Leu Lys 
 1745                1750                1755                1760
His Gln Ile Glu Asp Asn Val Ser Lys Gln Ala Asn Leu Glu Ala Thr 
                 1765                1770                1775
Glu Lys His Asp Asn Gln Thr Asn Val Thr Glu Glu Gly Thr Gln Ser 
             1780                1785                1790
Ile Pro Gly Glu Thr Glu Glu Gln Asp Ser Leu Ser Met Ser Thr Arg 
         1795                1800                1805
Pro Thr Cys Ser Glu Ser Val Pro Ser Ala Lys Ser Ala Asn Pro Ala 
     1810                1815                1820
Val Ser Lys Asp Phe Ser Ser His Asp Glu Ile Asn Asn Tyr Leu Gln 
 1825                1830                1835                1840
Gln Ile Asp Gln Leu Lys Glu Arg Ile Ala Gly Leu Glu Glu Glu Lys 
                 1845                1850                1855
Gln Lys Asn Lys Glu Phe Ser Gln Thr Leu Glu Asn Glu Lys Asn Thr 
             1860                1865                1870
Leu Leu Ser Gln Ile Ser Thr Lys Asp Gly Glu Leu Lys Met Leu Gln 
         1875                1880                1885
Glu Glu Val Thr Lys Met Asn Leu Leu Asn Gln Gln Ile Gln Glu Glu 
     1890                1895                1900
Leu Ser Arg Val Thr Lys Leu Lys Glu Thr Ala Glu Glu Glu Lys Asp 
 1905                1910                1915                1920
Asp Leu Glu Glu Arg Leu Met Asn Gln Leu Ala Glu Leu Asn Gly Ser 
                 1925                1930                1935
Ile Gly Asn Tyr Cys Gln Asp Val Thr Asp Ala Gln Ile Lys Asn Glu 
             1940                1945                1950
Leu Leu Glu Ser Glu Met Lys Asn Leu Lys Lys Cys Val Ser Glu Leu 
         1955                1960                1965
Glu Glu Glu Lys Gln Gln Leu Val Lys Glu Lys Thr Lys Val Glu Ser 
     1970                1975                1980
Glu Ile Arg Lys Glu Tyr Leu Glu Lys Ile Gln Gly Ala Gln Lys Glu 
 1985                1990                1995                2000
Pro Gly Asn Lys Ser His Ala Lys Glu Leu Gln Glu Leu Leu Lys Glu 
                 2005                2010                2015
Lys Gln Gln Glu Val Lys Gln Leu Gln Lys Asp Cys Ile Arg Tyr Gln 
             2020                2025                2030
Glu Lys Ile Ser Ala Leu Glu Arg Thr Val Lys Ala Leu Glu Phe Val 
         2035                2040                2045
Gln Thr Glu Ser Gln Lys Asp Leu Glu Ile Thr Lys Glu Asn Leu Ala 
     2050                2055                2060
Gln Ala Val Glu His Arg Lys Lys Ala Gln Ala Glu Leu Ala Ser Phe 
 2065                2070                2075                2080
Lys Val Leu Leu Asp Asp Thr Gln Ser Glu Ala Ala Arg Val Leu Ala 
                 2085                2090                2095
Asp Asn Leu Lys Leu Lys Lys Glu Leu Gln Ser Asn Lys Glu Ser Val 
             2100                2105                2110
Lys Ser Gln Met Lys Gln Lys Asp Glu Asp Leu Glu Arg Arg Leu Glu 
         2115                2120                2125
Gln Ala Glu Glu Lys His Leu Lys Glu Lys Lys Asn Met Gln Glu Lys 
     2130                2135                2140
Leu Asp Ala Leu Arg Arg Glu Lys Val His Leu Glu Glu Thr Ile Gly 
 2145                2150                2155                2160
Glu Ile Gln Val Thr Leu Asn Lys Lys Asp Lys Glu Val Gln Gln Leu 
                 2165                2170                2175
Gln Glu Asn Leu Asp Ser Thr Val Thr Gln Leu Ala Ala Phe Thr Lys 
             2180                2185                2190
Ser Met Ser Ser Leu Gln Asp Asp Arg Asp Arg Val Ile Asp Glu Ala 
         2195                2200                2205
Lys Lys Trp Glu Arg Lys Phe Ser Asp Ala Ile Gln Ser Lys Glu Glu 
     2210                2215                2220
Glu Ile Arg Leu Lys Glu Asp Asn Cys Ser Val Leu Lys Asp Gln Leu 
 2225                2230                2235                2240
Arg Gln Met Ser Ile His Met Glu Glu Leu Lys Ile Asn Ile Ser Arg 
                 2245                2250                2255
Leu Glu His Asp Lys Gln Ile Trp Glu Ser Lys Ala Gln Thr Glu Val 
             2260                2265                2270
Gln Leu Gln Gln Lys Val Cys Asp Thr Leu Gln Gly Glu Asn Lys Glu 
         2275                2280                2285
Leu Leu Ser Gln Leu Glu Glu Thr Arg His Leu Tyr His Ser Ser Gln 
     2290                2295                2300
Asn Glu Leu Ala Lys Leu Glu Ser Glu Leu Lys Ser Leu Lys Asp Gln 
 2305                2310                2315                2320
Leu Thr Asp Leu Ser Asn Ser Leu Glu Lys Cys Lys Glu Gln Lys Gly 
                 2325                2330                2335
Asn Leu Glu Gly Ile Ile Arg Gln Gln Glu Ala Asp Ile Gln Asn Ser 
             2340                2345                2350
Lys Phe Ser Tyr Glu Gln Leu Glu Thr Asp Leu Gln Ala Ser Arg Glu 
         2355                2360                2365
Leu Thr Ser Arg Leu His Glu Glu Ile Asn Met Lys Glu Gln Lys Ile 
     2370                2375                2380
Ile Ser Leu Leu Ser Gly Lys Glu Glu Ala Ile Gln Val Ala Ile Ala 
 2385                2390                2395                2400
Glu Leu Arg Gln Gln His Asp Lys Glu Ile Lys Glu Leu Glu Asn Leu 
                 2405                2410                2415
Leu Ser Gln Glu Glu Glu Glu Asn Ile Val Leu Glu Glu Glu Asn Lys 
             2420                2425                2430
Lys Ala Val Asp Lys Thr Asn Gln Leu Met Glu Thr Leu Lys Thr Ile 
         2435                2440                2445
Lys Lys Glu Asn Ile Gln Gln Lys Ala Gln Leu Asp Ser Phe Val Lys 
     2450                2455                2460
Ser Met Ser Ser Leu Gln Asn Asp Arg Asp Arg Ile Val Gly Asp Tyr 
 2465                2470                2475                2480
Gln Gln Leu Glu Glu Arg His Leu Ser Ile Ile Leu Glu Lys Asp Gln 
                 2485                2490                2495
Leu Ile Gln Glu Ala Ala Ala Glu Asn Asn Lys Leu Lys Glu Glu Ile 
             2500                2505                2510
Arg Gly Leu Arg Ser His Met Asp Asp Leu Asn Ser Glu Asn Ala Lys 
         2515                2520                2525
Leu Asp Ala Glu Leu Ile Gln Tyr Arg Glu Asp Leu Asn Gln Val Ile 
     2530                2535                2540
Thr Ile Lys Asp Ser Gln Gln Lys Gln Leu Leu Glu Val Gln Leu Gln 
 2545                2550                2555                2560
Gln Asn Lys Glu Leu Glu Asn Lys Tyr Ala Lys Leu Glu Glu Lys Leu 
                 2565                2570                2575
Lys Glu Ser Glu Glu Ala Asn Glu Asp Leu Arg Arg Ser Phe Asn Ala 
             2580                2585                2590
Leu Gln Glu Glu Lys Gln Asp Leu Ser Lys Glu Ile Glu Ser Leu Lys 
         2595                2600                2605
Val Ser Ile Ser Gln Leu Thr Arg Gln Val Thr Ala Leu Gln Glu Glu 
     2610                2615                2620
Gly Thr Leu Gly Leu Tyr His Ala Gln Leu Lys Val Lys Glu Glu Glu 
 2625                2630                2635                2640
Val His Arg Leu Ser Ala Leu Phe Ser Ser Ser Gln Lys Arg Ile Ala 
                 2645                2650                2655
Glu Leu Glu Glu Glu Leu Val Cys Val Gln Lys Glu Ala Ala Lys Lys 
             2660                2665                2670
Val Gly Glu Ile Glu Asp Lys Leu Lys Lys Glu Leu Lys His Leu His 
         2675                2680                2685
His Asp Ala Gly Ile Met Arg Asn Glu Thr Glu Thr Ala Glu Glu Arg 
     2690                2695                2700
Val Ala Glu Leu Ala Arg Asp Leu Val Glu Met Glu Gln Lys Leu Leu 
 2705                2710                2715                2720
Met Val Thr Lys Glu Asn Lys Gly Leu Thr Ala Gln Ile Gln Ser Phe 
                 2725                2730                2735
Gly Arg Ser Met Ser Ser Leu Gln Asn Ser Arg Asp His Ala Asn Glu 
             2740                2745                2750
Glu Leu Asp Glu Leu Lys Arg Lys Tyr Asp Ala Ser Leu Lys Glu Leu 
         2755                2760                2765
Ala Gln Leu Lys Glu Gln Gly Leu Leu Asn Arg Glu Arg Asp Ala Leu 
     2770                2775                2780
Leu Ser Glu Thr Ala Phe Ser Met Asn Ser Thr Glu Glu Asn Ser Leu 
 2785                2790                2795                2800
Ser His Leu Glu Lys Leu Asn Gln Gln Leu Leu Ser Lys Asp Glu Gln 
                 2805                2810                2815
Leu Leu His Leu Ser Ser Gln Leu Glu Asp Ser Tyr Asn Gln Val Gln 
             2820                2825                2830
Ser Phe Ser Lys Ala Met Ala Ser Leu Gln Asn Glu Arg Asp His Leu 
         2835                2840                2845
Trp Asn Glu Leu Glu Lys Phe Arg Lys Ser Glu Glu Gly Lys Gln Arg 
     2850                2855                2860
Ser Ala Ala Gln Pro Ser Thr Ser Pro Ala Glu Val Gln Ser Leu Lys 
 2865                2870                2875                2880
Lys Ala Met Ser Ser Leu Gln Asn Asp Arg Asp Arg Leu Leu Lys Glu 
                 2885                2890                2895
Leu Lys Asn Leu Gln Gln Gln Tyr Leu Gln Ile Asn Gln Glu Ile Thr 
             2900                2905                2910
Glu Leu His Pro Leu Lys Ala Gln Leu Gln Glu Tyr Gln Asp Lys Thr 
         2915                2920                2925
Lys Ala Phe Gln Ile Met Gln Glu Glu Leu Arg Gln Glu Asn Leu Ser 
     2930                2935                2940
Trp Gln His Glu Leu His Gln Leu Arg Met Glu Lys Ser Ser Trp Glu 
 2945                2950                2955                2960
Ile His Glu Arg Arg Met Lys Glu Gln Tyr Leu Met Ala Ile Ser Asp 
                 2965                2970                2975
Lys Asp Gln Gln Leu Ser His Leu Gln Asn Leu Ile Arg Glu Leu Arg 
             2980                2985                2990
Ser Ser Ser Ser Gln Thr Gln Pro Leu Lys Val Gln Tyr Gln Arg Gln 
         2995                3000                3005
Ala Ser Pro Glu Thr Ser Ala Ser Pro Asp Gly Ser Gln Asn Leu Val 
     3010                3015                3020
Tyr Glu Thr Glu Leu Leu Arg Thr Gln Leu Asn Asp Ser Leu Lys Glu 
 3025                3030                3035                3040
Ile His Gln Lys Glu Leu Arg Ile Gln Gln Leu Asn Ser Asn Phe Ser 
                 3045                3050                3055
Gln Leu Leu Glu Glu Lys Asn Thr Leu Ser Ile Gln Leu Cys Asp Thr 
             3060                3065                3070
Ser Gln Ser Leu Arg Glu Asn Gln Gln His Tyr Gly Asp Leu Leu Asn 
         3075                3080                3085
His Cys Ala Val Leu Glu Lys Gln Val Gln Glu Leu Gln Ala Gly Pro 
     3090                3095                3100
Leu Asn Ile Asp Val Ala Pro Gly Ala Pro Gln Glu Lys Asn Gly Val 
 3105                3110                3115                3120
His Arg Lys Ser Asp Pro Glu Glu Leu Arg Glu Pro Gln Gln Ser Phe 
                 3125                3130                3135
Ser Glu Ala Gln Gln Gln Leu Cys Asn Thr Arg Gln Glu Val Asn Glu 
             3140                3145                3150
Leu Arg Lys Leu Leu Glu Glu Glu Arg Asp Gln Arg Val Ala Ala Glu 
         3155                3160                3165
Asn Ala Leu Ser Val Ala Glu Glu Gln Ile Arg Arg Leu Glu His Ser 
     3170                3175                3180
Glu Trp Asp Ser Ser Arg Thr Pro Ile Ile Gly Ser Cys Gly Thr Gln 
 3185                3190                3195                3200
Glu Gln Ala Leu Leu Ile Asp Leu Thr Ser Asn Ser Cys Arg Arg Thr 
                 3205                3210                3215
Arg Ser Gly Val Gly Trp Lys Arg Val Leu Arg Ser Leu Cys His Ser 
             3220                3225                3230
Arg Thr Arg Val Pro Leu Leu Ala Ala Ile Tyr Phe Leu Met Ile His 
         3235                3240                3245
Val Leu Leu Ile Leu Cys Phe Thr Gly His Leu 
     3250                3255



<210> 1877
<211> 1581
<212> DNA
<213> Rattus norvegicus
<308> D26073
<400> 1877

cacagctgt  cccacatcc  gccccgcgc  gaccgcttg  agccgcttc  cgggccgga  60
gatgcccag  aagctgctg  tactgcccc  gctgtccgc  tgctccgct  tgcgcgtcc  120
cgggcccgg  ccgccgcct  gccggccat  aacgccgcc  gcactggct  ccgagtctt  180
tcggccaac  ccacggccg  ctgcacgga  ctggccaag  gcatcactg  gcgtcttgg  240
gctgaattg  ggaaatctg  tgtttatca  gagaccaat  gagaaacca  agttgaaat  300
aaagagtct  ttcgtggcc  agatatttt  attatacaa  ccataccca  agatgtgaa  360
acggccgtg  tggagctgc  gatcatggc  tacgccctg  agactgcct  tgccaggaa  420
atcatcggt  tcatcccct  cttccccta  agcaaacaa  gcaagatga  gaagagggg  480
tccattgtg  gcaagctcc  ggcatccat  ctggcaaaa  ctggtctaa  tcacattat  540
actatggat  ttcaccaaa  ggaaataca  ggctttttc  gcttccccg  ggacaacct  600
agagcctca  ctttcctgc  ccagtatat  caggaagaa  ttccaaatt  cagaaatgc  660
gtcattgta  ctaagtctc  tgatgctgc  aaaagggct  agtcctatg  agagagact  720
cgcctgggc  tggctgtga  ccacggaga  gctcagtgc  cagagctag  catggatga  780
ggtcgacac  cacccccca  ggtcaagaa  gccactgtg  accccggcc  ggagctacc  840
ttgatgatg  ccaaagaga  gccaccaat  acagtggtc  gagacgtcg  gggacgcat  900
gcaatcata  tggatgaca  cattgatga  gtggagagc  ttgttgctg  tgcagagac  960
ctgaaagag  gaggtgctt  caagatcta  gtcatggcc  cgcacggca  cctgtctgc  1020
gaagctccc  gtctgatcg  ggagtcccc  attgatgag  tggtggtga  gaacactgt  1080
cctcacgag  ttcagaaac  acagtgtcc  aagataaag  ctgtggaca  cagcttgat  1140
ctttctgag  cgattcgga  aatccataa  ggcgaatcc  tggcttacc  cttccggaa  1200
atcacagtg  atgattagc  ccgagctgc  ttgacctgc  ggggagcac  cagcagtgt  1260
agccggcag  caggctgcc  agtcccttc  cccccatca  cagaatgca  cctatttgg  1320
aatacgtcc  gcggaagag  caggctctg  cacagcagg  atccagttg  agactgagt  1380
cccacgctg  tttgttcac  agtgtctgc  ctggggaag  caggtgagg  gttgagctt  1440
gtcagggag  tgagtggcc  tggcactga  gcgtgcagt  gtaccattg  acatgaagg  1500
tccccggct  ctttcacgg  gctcgtcag  tgagagcgg  gcagcctgt  cctcagaac  1560
gtgttgctg  aaataaaag  t  1581



<210> 1878
<211> 356
<212> PRT
<213> Rattus norvegicus
<308> BAA05068
<400> 1878

Met Asn Ala Ala Arg Thr Gly Tyr Arg Val Phe Ser Ala Asn Ser Thr 
  1               5                  10                  15
Ala Ala Cys Thr Glu Leu Ala Lys Arg Ile Thr Glu Arg Leu Gly Ala 
             20                  25                  30
Glu Leu Gly Lys Ser Val Val Tyr Gln Glu Thr Asn Gly Glu Thr Arg 
         35                  40                  45
Val Glu Ile Lys Glu Ser Val Arg Gly Gln Asp Ile Phe Ile Ile Gln 
     50                  55                  60
Thr Ile Pro Arg Asp Val Asn Thr Ala Val Met Glu Leu Leu Ile Met 
 65                  70                  75                  80
Ala Tyr Ala Leu Lys Thr Ala Cys Ala Arg Asn Ile Ile Gly Val Ile 
                 85                  90                  95
Pro Tyr Phe Pro Tyr Ser Lys Gln Ser Lys Met Arg Lys Arg Gly Ser 
             100                105                110
Ile Val Cys Lys Leu Leu Ala Ser Met Leu Ala Lys Ala Gly Leu Thr 
         115                120                125
His Ile Ile Thr Met Asp Leu His Gln Lys Glu Ile Gln Gly Phe Phe 
     130                135                140
Cys Phe Pro Val Asp Asn Leu Arg Ala Ser Pro Phe Leu Leu Gln Tyr 
 145                150                155                160
Ile Gln Glu Glu Ile Pro Asn Tyr Arg Asn Ala Val Ile Val Ala Lys 
                 165                170                175
Ser Pro Asp Ala Ala Lys Arg Ala Gln Ser Tyr Ala Glu Arg Leu Arg 
             180                185                190
Leu Gly Leu Ala Val Ile His Gly Glu Ala Gln Cys Thr Glu Leu Asp 
         195                200                205
Met Asp Asp Gly Arg His Ser Pro Pro Met Val Lys Asn Ala Thr Val 
     210                215                220
His Pro Gly Leu Glu Leu Pro Leu Met Met Ala Lys Glu Lys Pro Pro 
 225                230                235                240
Ile Thr Val Val Gly Asp Val Gly Gly Arg Ile Ala Ile Ile Val Asp 
                 245                250                255
Asp Ile Ile Asp Asp Val Glu Ser Phe Val Ala Ala Ala Glu Thr Leu 
             260                265                270
Lys Glu Arg Gly Ala Tyr Lys Ile Tyr Val Met Ala Thr His Gly Ile 
         275                280                285
Leu Ser Ala Glu Ala Pro Arg Leu Ile Glu Glu Ser Pro Ile Asp Glu 
     290                295                300
Val Val Val Thr Asn Thr Val Pro His Glu Leu Gln Lys Leu Gln Cys 
 305                310                315                320
Pro Lys Ile Lys Thr Val Asp Ile Ser Leu Ile Leu Ser Glu Ala Ile 
                 325                330                335
Arg Arg Ile His Asn Gly Glu Ser Met Ala Tyr Leu Phe Arg Asn Ile 
             340                345                350
Thr Val Asp Asp 
         355



<210> 1879
<211> 1581
<212> DNA
<213> Rattus norvegicus
<308> D26073
<400> 1879

cacagctgt  cccacatcc  gccccgcgc  gaccgcttg  agccgcttc  cgggccgga  60
gatgcccag  aagctgctg  tactgcccc  gctgtccgc  tgctccgct  tgcgcgtcc  120
cgggcccgg  ccgccgcct  gccggccat  aacgccgcc  gcactggct  ccgagtctt  180
tcggccaac  ccacggccg  ctgcacgga  ctggccaag  gcatcactg  gcgtcttgg  240
gctgaattg  ggaaatctg  tgtttatca  gagaccaat  gagaaacca  agttgaaat  300
aaagagtct  ttcgtggcc  agatatttt  attatacaa  ccataccca  agatgtgaa  360
acggccgtg  tggagctgc  gatcatggc  tacgccctg  agactgcct  tgccaggaa  420
atcatcggt  tcatcccct  cttccccta  agcaaacaa  gcaagatga  gaagagggg  480
tccattgtg  gcaagctcc  ggcatccat  ctggcaaaa  ctggtctaa  tcacattat  540
actatggat  ttcaccaaa  ggaaataca  ggctttttc  gcttccccg  ggacaacct  600
agagcctca  ctttcctgc  ccagtatat  caggaagaa  ttccaaatt  cagaaatgc  660
gtcattgta  ctaagtctc  tgatgctgc  aaaagggct  agtcctatg  agagagact  720
cgcctgggc  tggctgtga  ccacggaga  gctcagtgc  cagagctag  catggatga  780
ggtcgacac  cacccccca  ggtcaagaa  gccactgtg  accccggcc  ggagctacc  840
ttgatgatg  ccaaagaga  gccaccaat  acagtggtc  gagacgtcg  gggacgcat  900
gcaatcata  tggatgaca  cattgatga  gtggagagc  ttgttgctg  tgcagagac  960
ctgaaagag  gaggtgctt  caagatcta  gtcatggcc  cgcacggca  cctgtctgc  1020
gaagctccc  gtctgatcg  ggagtcccc  attgatgag  tggtggtga  gaacactgt  1080
cctcacgag  ttcagaaac  acagtgtcc  aagataaag  ctgtggaca  cagcttgat  1140
ctttctgag  cgattcgga  aatccataa  ggcgaatcc  tggcttacc  cttccggaa  1200
atcacagtg  atgattagc  ccgagctgc  ttgacctgc  ggggagcac  cagcagtgt  1260
agccggcag  caggctgcc  agtcccttc  cccccatca  cagaatgca  cctatttgg  1320
aatacgtcc  gcggaagag  caggctctg  cacagcagg  atccagttg  agactgagt  1380
cccacgctg  tttgttcac  agtgtctgc  ctggggaag  caggtgagg  gttgagctt  1440
gtcagggag  tgagtggcc  tggcactga  gcgtgcagt  gtaccattg  acatgaagg  1500
tccccggct  ctttcacgg  gctcgtcag  tgagagcgg  gcagcctgt  cctcagaac  1560
gtgttgctg  aaataaaag  t  1581



<210> 1880
<211> 356
<212> PRT
<213> Rattus norvegicus
<308> BAA05068
<400> 1880

Met Asn Ala Ala Arg Thr Gly Tyr Arg Val Phe Ser Ala Asn Ser Thr 
  1               5                  10                  15
Ala Ala Cys Thr Glu Leu Ala Lys Arg Ile Thr Glu Arg Leu Gly Ala 
             20                  25                  30
Glu Leu Gly Lys Ser Val Val Tyr Gln Glu Thr Asn Gly Glu Thr Arg 
         35                  40                  45
Val Glu Ile Lys Glu Ser Val Arg Gly Gln Asp Ile Phe Ile Ile Gln 
     50                  55                  60
Thr Ile Pro Arg Asp Val Asn Thr Ala Val Met Glu Leu Leu Ile Met 
 65                  70                  75                  80
Ala Tyr Ala Leu Lys Thr Ala Cys Ala Arg Asn Ile Ile Gly Val Ile 
                 85                  90                  95
Pro Tyr Phe Pro Tyr Ser Lys Gln Ser Lys Met Arg Lys Arg Gly Ser 
             100                105                110
Ile Val Cys Lys Leu Leu Ala Ser Met Leu Ala Lys Ala Gly Leu Thr 
         115                120                125
His Ile Ile Thr Met Asp Leu His Gln Lys Glu Ile Gln Gly Phe Phe 
     130                135                140
Cys Phe Pro Val Asp Asn Leu Arg Ala Ser Pro Phe Leu Leu Gln Tyr 
 145                150                155                160
Ile Gln Glu Glu Ile Pro Asn Tyr Arg Asn Ala Val Ile Val Ala Lys 
                 165                170                175
Ser Pro Asp Ala Ala Lys Arg Ala Gln Ser Tyr Ala Glu Arg Leu Arg 
             180                185                190
Leu Gly Leu Ala Val Ile His Gly Glu Ala Gln Cys Thr Glu Leu Asp 
         195                200                205
Met Asp Asp Gly Arg His Ser Pro Pro Met Val Lys Asn Ala Thr Val 
     210                215                220
His Pro Gly Leu Glu Leu Pro Leu Met Met Ala Lys Glu Lys Pro Pro 
 225                230                235                240
Ile Thr Val Val Gly Asp Val Gly Gly Arg Ile Ala Ile Ile Val Asp 
                 245                250                255
Asp Ile Ile Asp Asp Val Glu Ser Phe Val Ala Ala Ala Glu Thr Leu 
             260                265                270
Lys Glu Arg Gly Ala Tyr Lys Ile Tyr Val Met Ala Thr His Gly Ile 
         275                280                285
Leu Ser Ala Glu Ala Pro Arg Leu Ile Glu Glu Ser Pro Ile Asp Glu 
     290                295                300
Val Val Val Thr Asn Thr Val Pro His Glu Leu Gln Lys Leu Gln Cys 
 305                310                315                320
Pro Lys Ile Lys Thr Val Asp Ile Ser Leu Ile Leu Ser Glu Ala Ile 
                 325                330                335
Arg Arg Ile His Asn Gly Glu Ser Met Ala Tyr Leu Phe Arg Asn Ile 
             340                345                350
Thr Val Asp Asp 
         355



<210> 1881
<211> 1746
<212> DNA
<213> Rattus norvegicus
<308> D26154
<400> 1881

tccgcagct  taccgccta  tcttcctgg  tgtttgggc  gtttgattt  tttaaagat  60
ataagcatt  tccagttat  catcatgct  tatctatag  ctatgccat  tgacatatt  120
ggcaatgct  tattatgaa  acacatgta  acctctctg  aacctgtgt  taacccagc  180
tagttgtag  atgtggttg  attaatgaa  gttacaggc  aggggaccg  ctcctggct  240
aggagacag  tgccaccat  tcagccatt  aagccatga  gaatgctca  cgagaggag  300
tggaacggg  gttagagaa  agccagcgg  ctcagatca  cagcatcaa  tcagacata  360
aagccctga  gcgacagta  ctggaggag  tacagtcag  gcagcgaga  ctggaggtc  420
tttcggagc  gtactctca  aagtgtctg  agaatgcac  cctagccca  gcgctggaa  480
ctgagcggc  agccctgcg  cagtgtcag  gtgagaacc  agagctcaa  gcccacaac  540
aggagctga  taaccgcct  gctgcggag  tcacacggt  gcggacact  ctgactgga  600
aaggtggtg  ggaatccac  gggttggct  tcacacagg  caaggatgc  tatgagtta  660
aggtcttgt  gggggtcaa  gagtcagaa  ttcagttcc  gaaacagga  atcagctct  720
tcaaggatg  actccagac  gccctgcgg  ataagaagt  tgcgagcga  aagtacaaa  780
acatctaca  agagctcag  atcgcgaag  ccaaggctg  ctgtgacat  agcaggctg  840
aggagcagc  gaaagcagc  acagaggca  tgggcgaga  atctcctga  ggcactact  900
tgtcaggat  tgacataat  aaatctaaa  gcaatcctg  cttcctgaa  aaagacaga  960
cctgtgtta  ccggcaact  agaaacatc  ggtccaagt  cgtaattga  caggtctca  1020
gggataact  agtcgcgcc  gcttccaag  cccctgtcg  agtctgaag  aaggcctga  1080
ggtgcagga  cgcttgaag  tctttgaat  cagggactt  aagaaagat  agctgcatc  1140
attccactg  cacatcctt  ccagctggt  gcagcacaa  ccaagagtg  gtttcatct  1200
tgctttctc  ttgttgctg  cattaactg  gggtatgga  gcatgagag  ctgctgtgg  1260
gtgtttggt  cattccctc  ctgttaatt  caacttcct  ttgtcttta  cacagcttt  1320
ttcccatgg  attctcaga  tagtcacgc  aaagcagta  agtggggag  tgtccccac  1380
gacacctga  cagcccctt  tcctcccac  acactgtca  tattaaggc  caacagcct  1440
ttaataagc  agccctgcc  cggagtgca  gtgggggac  ggacctgtc  gtggctctg  1500
tctgccaca  acagcggag  accaccctt  ctgggtaga  cagacccca  cgaatgttc  1560
aggttgacc  ggtttctga  gggcctagg  tagtgtcca  cctggccca  ttccttttg  1620
tgtgggagg  ggacagcat  ttgtatttg  cccactaat  cagcttaga  ccataccca  1680
ataatcctg  caaatcttt  acgacctgg  aaatgttga  agcaaccat  cctattttg  1740
tttttt  1746



<210> 1882
<211> 251
<212> PRT
<213> Rattus norvegicus
<308> BAA05141
<400> 1882

Met Lys Asn Ala His Arg Glu Glu Met Glu Arg Glu Leu Glu Lys Ser 
  1               5                  10                  15
Gln Arg Ser Gln Ile Ser Ser Ile Asn Ser Asp Ile Glu Ala Leu Arg 
             20                  25                  30
Arg Gln Tyr Leu Glu Glu Leu Gln Ser Val Gln Arg Glu Leu Glu Val 
         35                  40                  45
Leu Ser Glu Gln Tyr Ser Gln Lys Cys Leu Glu Asn Ala His Leu Ala 
     50                  55                  60
Gln Ala Leu Glu Ala Glu Arg Gln Ala Leu Arg Gln Cys Gln Arg Glu 
 65                  70                  75                  80
Asn Gln Glu Leu Asn Ala His Asn Gln Glu Leu Asn Asn Arg Leu Ala 
                 85                  90                  95
Ala Glu Ile Thr Arg Leu Arg Thr Leu Leu Thr Gly Glu Gly Gly Gly 
             100                105                110
Glu Ser Thr Gly Leu Ala Leu Thr Gln Gly Lys Asp Ala Tyr Glu Leu 
         115                120                125
Glu Val Leu Leu Gly Val Asn Glu Ser Glu Val Gln Phe Leu Lys Gln 
     130                135                140
Glu Ile Ser Ser Leu Lys Asp Glu Leu Gln Thr Ala Leu Arg Asp Lys 
 145                150                155                160
Lys Phe Ala Ser Asp Lys Tyr Lys Asp Ile Tyr Thr Glu Leu Ser Ile 
                 165                170                175
Ala Lys Ala Lys Ala Asp Cys Asp Ile Ser Arg Leu Lys Glu Gln Leu 
             180                185                190
Lys Ala Ala Thr Glu Ala Leu Gly Glu Lys Ser Pro Glu Gly Thr Thr 
         195                200                205
Val Ser Gly Tyr Asp Ile Met Lys Ser Lys Ser Asn Pro Asp Phe Leu 
     210                215                220
Lys Lys Asp Arg Ser Cys Val Thr Arg Gln Leu Arg Asn Ile Arg Ser 
 225                230                235                240
Lys Ser Val Ile Glu Gln Val Ser Trp Asp Asn 
                 245                250



<210> 1883
<211> 1746
<212> DNA
<213> Rattus norvegicus
<308> D26154
<400> 1883

tccgcagct  taccgccta  tcttcctgg  tgtttgggc  gtttgattt  tttaaagat  60
ataagcatt  tccagttat  catcatgct  tatctatag  ctatgccat  tgacatatt  120
ggcaatgct  tattatgaa  acacatgta  acctctctg  aacctgtgt  taacccagc  180
tagttgtag  atgtggttg  attaatgaa  gttacaggc  aggggaccg  ctcctggct  240
aggagacag  tgccaccat  tcagccatt  aagccatga  gaatgctca  cgagaggag  300
tggaacggg  gttagagaa  agccagcgg  ctcagatca  cagcatcaa  tcagacata  360
aagccctga  gcgacagta  ctggaggag  tacagtcag  gcagcgaga  ctggaggtc  420
tttcggagc  gtactctca  aagtgtctg  agaatgcac  cctagccca  gcgctggaa  480
ctgagcggc  agccctgcg  cagtgtcag  gtgagaacc  agagctcaa  gcccacaac  540
aggagctga  taaccgcct  gctgcggag  tcacacggt  gcggacact  ctgactgga  600
aaggtggtg  ggaatccac  gggttggct  tcacacagg  caaggatgc  tatgagtta  660
aggtcttgt  gggggtcaa  gagtcagaa  ttcagttcc  gaaacagga  atcagctct  720
tcaaggatg  actccagac  gccctgcgg  ataagaagt  tgcgagcga  aagtacaaa  780
acatctaca  agagctcag  atcgcgaag  ccaaggctg  ctgtgacat  agcaggctg  840
aggagcagc  gaaagcagc  acagaggca  tgggcgaga  atctcctga  ggcactact  900
tgtcaggat  tgacataat  aaatctaaa  gcaatcctg  cttcctgaa  aaagacaga  960
cctgtgtta  ccggcaact  agaaacatc  ggtccaagt  cgtaattga  caggtctca  1020
gggataact  agtcgcgcc  gcttccaag  cccctgtcg  agtctgaag  aaggcctga  1080
ggtgcagga  cgcttgaag  tctttgaat  cagggactt  aagaaagat  agctgcatc  1140
attccactg  cacatcctt  ccagctggt  gcagcacaa  ccaagagtg  gtttcatct  1200
tgctttctc  ttgttgctg  cattaactg  gggtatgga  gcatgagag  ctgctgtgg  1260
gtgtttggt  cattccctc  ctgttaatt  caacttcct  ttgtcttta  cacagcttt  1320
ttcccatgg  attctcaga  tagtcacgc  aaagcagta  agtggggag  tgtccccac  1380
gacacctga  cagcccctt  tcctcccac  acactgtca  tattaaggc  caacagcct  1440
ttaataagc  agccctgcc  cggagtgca  gtgggggac  ggacctgtc  gtggctctg  1500
tctgccaca  acagcggag  accaccctt  ctgggtaga  cagacccca  cgaatgttc  1560
aggttgacc  ggtttctga  gggcctagg  tagtgtcca  cctggccca  ttccttttg  1620
tgtgggagg  ggacagcat  ttgtatttg  cccactaat  cagcttaga  ccataccca  1680
ataatcctg  caaatcttt  acgacctgg  aaatgttga  agcaaccat  cctattttg  1740
tttttt  1746



<210> 1884
<211> 251
<212> PRT
<213> Rattus norvegicus
<308> BAA05141
<400> 1884

Met Lys Asn Ala His Arg Glu Glu Met Glu Arg Glu Leu Glu Lys Ser 
  1               5                  10                  15
Gln Arg Ser Gln Ile Ser Ser Ile Asn Ser Asp Ile Glu Ala Leu Arg 
             20                  25                  30
Arg Gln Tyr Leu Glu Glu Leu Gln Ser Val Gln Arg Glu Leu Glu Val 
         35                  40                  45
Leu Ser Glu Gln Tyr Ser Gln Lys Cys Leu Glu Asn Ala His Leu Ala 
     50                  55                  60
Gln Ala Leu Glu Ala Glu Arg Gln Ala Leu Arg Gln Cys Gln Arg Glu 
 65                  70                  75                  80
Asn Gln Glu Leu Asn Ala His Asn Gln Glu Leu Asn Asn Arg Leu Ala 
                 85                  90                  95
Ala Glu Ile Thr Arg Leu Arg Thr Leu Leu Thr Gly Glu Gly Gly Gly 
             100                105                110
Glu Ser Thr Gly Leu Ala Leu Thr Gln Gly Lys Asp Ala Tyr Glu Leu 
         115                120                125
Glu Val Leu Leu Gly Val Asn Glu Ser Glu Val Gln Phe Leu Lys Gln 
     130                135                140
Glu Ile Ser Ser Leu Lys Asp Glu Leu Gln Thr Ala Leu Arg Asp Lys 
 145                150                155                160
Lys Phe Ala Ser Asp Lys Tyr Lys Asp Ile Tyr Thr Glu Leu Ser Ile 
                 165                170                175
Ala Lys Ala Lys Ala Asp Cys Asp Ile Ser Arg Leu Lys Glu Gln Leu 
             180                185                190
Lys Ala Ala Thr Glu Ala Leu Gly Glu Lys Ser Pro Glu Gly Thr Thr 
         195                200                205
Val Ser Gly Tyr Asp Ile Met Lys Ser Lys Ser Asn Pro Asp Phe Leu 
     210                215                220
Lys Lys Asp Arg Ser Cys Val Thr Arg Gln Leu Arg Asn Ile Arg Ser 
 225                230                235                240
Lys Ser Val Ile Glu Gln Val Ser Trp Asp Asn 
                 245                250



<210> 1885
<211> 1746
<212> DNA
<213> Rattus norvegicus
<308> D26154
<400> 1885

tccgcagct  taccgccta  tcttcctgg  tgtttgggc  gtttgattt  tttaaagat  60
ataagcatt  tccagttat  catcatgct  tatctatag  ctatgccat  tgacatatt  120
ggcaatgct  tattatgaa  acacatgta  acctctctg  aacctgtgt  taacccagc  180
tagttgtag  atgtggttg  attaatgaa  gttacaggc  aggggaccg  ctcctggct  240
aggagacag  tgccaccat  tcagccatt  aagccatga  gaatgctca  cgagaggag  300
tggaacggg  gttagagaa  agccagcgg  ctcagatca  cagcatcaa  tcagacata  360
aagccctga  gcgacagta  ctggaggag  tacagtcag  gcagcgaga  ctggaggtc  420
tttcggagc  gtactctca  aagtgtctg  agaatgcac  cctagccca  gcgctggaa  480
ctgagcggc  agccctgcg  cagtgtcag  gtgagaacc  agagctcaa  gcccacaac  540
aggagctga  taaccgcct  gctgcggag  tcacacggt  gcggacact  ctgactgga  600
aaggtggtg  ggaatccac  gggttggct  tcacacagg  caaggatgc  tatgagtta  660
aggtcttgt  gggggtcaa  gagtcagaa  ttcagttcc  gaaacagga  atcagctct  720
tcaaggatg  actccagac  gccctgcgg  ataagaagt  tgcgagcga  aagtacaaa  780
acatctaca  agagctcag  atcgcgaag  ccaaggctg  ctgtgacat  agcaggctg  840
aggagcagc  gaaagcagc  acagaggca  tgggcgaga  atctcctga  ggcactact  900
tgtcaggat  tgacataat  aaatctaaa  gcaatcctg  cttcctgaa  aaagacaga  960
cctgtgtta  ccggcaact  agaaacatc  ggtccaagt  cgtaattga  caggtctca  1020
gggataact  agtcgcgcc  gcttccaag  cccctgtcg  agtctgaag  aaggcctga  1080
ggtgcagga  cgcttgaag  tctttgaat  cagggactt  aagaaagat  agctgcatc  1140
attccactg  cacatcctt  ccagctggt  gcagcacaa  ccaagagtg  gtttcatct  1200
tgctttctc  ttgttgctg  cattaactg  gggtatgga  gcatgagag  ctgctgtgg  1260
gtgtttggt  cattccctc  ctgttaatt  caacttcct  ttgtcttta  cacagcttt  1320
ttcccatgg  attctcaga  tagtcacgc  aaagcagta  agtggggag  tgtccccac  1380
gacacctga  cagcccctt  tcctcccac  acactgtca  tattaaggc  caacagcct  1440
ttaataagc  agccctgcc  cggagtgca  gtgggggac  ggacctgtc  gtggctctg  1500
tctgccaca  acagcggag  accaccctt  ctgggtaga  cagacccca  cgaatgttc  1560
aggttgacc  ggtttctga  gggcctagg  tagtgtcca  cctggccca  ttccttttg  1620
tgtgggagg  ggacagcat  ttgtatttg  cccactaat  cagcttaga  ccataccca  1680
ataatcctg  caaatcttt  acgacctgg  aaatgttga  agcaaccat  cctattttg  1740
tttttt  1746



<210> 1886
<211> 251
<212> PRT
<213> Rattus norvegicus
<308> BAA05141
<400> 1886

Met Lys Asn Ala His Arg Glu Glu Met Glu Arg Glu Leu Glu Lys Ser 
  1               5                  10                  15
Gln Arg Ser Gln Ile Ser Ser Ile Asn Ser Asp Ile Glu Ala Leu Arg 
             20                  25                  30
Arg Gln Tyr Leu Glu Glu Leu Gln Ser Val Gln Arg Glu Leu Glu Val 
         35                  40                  45
Leu Ser Glu Gln Tyr Ser Gln Lys Cys Leu Glu Asn Ala His Leu Ala 
     50                  55                  60
Gln Ala Leu Glu Ala Glu Arg Gln Ala Leu Arg Gln Cys Gln Arg Glu 
 65                  70                  75                  80
Asn Gln Glu Leu Asn Ala His Asn Gln Glu Leu Asn Asn Arg Leu Ala 
                 85                  90                  95
Ala Glu Ile Thr Arg Leu Arg Thr Leu Leu Thr Gly Glu Gly Gly Gly 
             100                105                110
Glu Ser Thr Gly Leu Ala Leu Thr Gln Gly Lys Asp Ala Tyr Glu Leu 
         115                120                125
Glu Val Leu Leu Gly Val Asn Glu Ser Glu Val Gln Phe Leu Lys Gln 
     130                135                140
Glu Ile Ser Ser Leu Lys Asp Glu Leu Gln Thr Ala Leu Arg Asp Lys 
 145                150                155                160
Lys Phe Ala Ser Asp Lys Tyr Lys Asp Ile Tyr Thr Glu Leu Ser Ile 
                 165                170                175
Ala Lys Ala Lys Ala Asp Cys Asp Ile Ser Arg Leu Lys Glu Gln Leu 
             180                185                190
Lys Ala Ala Thr Glu Ala Leu Gly Glu Lys Ser Pro Glu Gly Thr Thr 
         195                200                205
Val Ser Gly Tyr Asp Ile Met Lys Ser Lys Ser Asn Pro Asp Phe Leu 
     210                215                220
Lys Lys Asp Arg Ser Cys Val Thr Arg Gln Leu Arg Asn Ile Arg Ser 
 225                230                235                240
Lys Ser Val Ile Glu Gln Val Ser Trp Asp Asn 
                 245                250



<210> 1887
<211> 1746
<212> DNA
<213> Rattus norvegicus
<308> D26154
<400> 1887

tccgcagct  taccgccta  tcttcctgg  tgtttgggc  gtttgattt  tttaaagat  60
ataagcatt  tccagttat  catcatgct  tatctatag  ctatgccat  tgacatatt  120
ggcaatgct  tattatgaa  acacatgta  acctctctg  aacctgtgt  taacccagc  180
tagttgtag  atgtggttg  attaatgaa  gttacaggc  aggggaccg  ctcctggct  240
aggagacag  tgccaccat  tcagccatt  aagccatga  gaatgctca  cgagaggag  300
tggaacggg  gttagagaa  agccagcgg  ctcagatca  cagcatcaa  tcagacata  360
aagccctga  gcgacagta  ctggaggag  tacagtcag  gcagcgaga  ctggaggtc  420
tttcggagc  gtactctca  aagtgtctg  agaatgcac  cctagccca  gcgctggaa  480
ctgagcggc  agccctgcg  cagtgtcag  gtgagaacc  agagctcaa  gcccacaac  540
aggagctga  taaccgcct  gctgcggag  tcacacggt  gcggacact  ctgactgga  600
aaggtggtg  ggaatccac  gggttggct  tcacacagg  caaggatgc  tatgagtta  660
aggtcttgt  gggggtcaa  gagtcagaa  ttcagttcc  gaaacagga  atcagctct  720
tcaaggatg  actccagac  gccctgcgg  ataagaagt  tgcgagcga  aagtacaaa  780
acatctaca  agagctcag  atcgcgaag  ccaaggctg  ctgtgacat  agcaggctg  840
aggagcagc  gaaagcagc  acagaggca  tgggcgaga  atctcctga  ggcactact  900
tgtcaggat  tgacataat  aaatctaaa  gcaatcctg  cttcctgaa  aaagacaga  960
cctgtgtta  ccggcaact  agaaacatc  ggtccaagt  cgtaattga  caggtctca  1020
gggataact  agtcgcgcc  gcttccaag  cccctgtcg  agtctgaag  aaggcctga  1080
ggtgcagga  cgcttgaag  tctttgaat  cagggactt  aagaaagat  agctgcatc  1140
attccactg  cacatcctt  ccagctggt  gcagcacaa  ccaagagtg  gtttcatct  1200
tgctttctc  ttgttgctg  cattaactg  gggtatgga  gcatgagag  ctgctgtgg  1260
gtgtttggt  cattccctc  ctgttaatt  caacttcct  ttgtcttta  cacagcttt  1320
ttcccatgg  attctcaga  tagtcacgc  aaagcagta  agtggggag  tgtccccac  1380
gacacctga  cagcccctt  tcctcccac  acactgtca  tattaaggc  caacagcct  1440
ttaataagc  agccctgcc  cggagtgca  gtgggggac  ggacctgtc  gtggctctg  1500
tctgccaca  acagcggag  accaccctt  ctgggtaga  cagacccca  cgaatgttc  1560
aggttgacc  ggtttctga  gggcctagg  tagtgtcca  cctggccca  ttccttttg  1620
tgtgggagg  ggacagcat  ttgtatttg  cccactaat  cagcttaga  ccataccca  1680
ataatcctg  caaatcttt  acgacctgg  aaatgttga  agcaaccat  cctattttg  1740
tttttt  1746



<210> 1888
<211> 251
<212> PRT
<213> Rattus norvegicus
<308> BAA05141
<400> 1888

Met Lys Asn Ala His Arg Glu Glu Met Glu Arg Glu Leu Glu Lys Ser 
  1               5                  10                  15
Gln Arg Ser Gln Ile Ser Ser Ile Asn Ser Asp Ile Glu Ala Leu Arg 
             20                  25                  30
Arg Gln Tyr Leu Glu Glu Leu Gln Ser Val Gln Arg Glu Leu Glu Val 
         35                  40                  45
Leu Ser Glu Gln Tyr Ser Gln Lys Cys Leu Glu Asn Ala His Leu Ala 
     50                  55                  60
Gln Ala Leu Glu Ala Glu Arg Gln Ala Leu Arg Gln Cys Gln Arg Glu 
 65                  70                  75                  80
Asn Gln Glu Leu Asn Ala His Asn Gln Glu Leu Asn Asn Arg Leu Ala 
                 85                  90                  95
Ala Glu Ile Thr Arg Leu Arg Thr Leu Leu Thr Gly Glu Gly Gly Gly 
             100                105                110
Glu Ser Thr Gly Leu Ala Leu Thr Gln Gly Lys Asp Ala Tyr Glu Leu 
         115                120                125
Glu Val Leu Leu Gly Val Asn Glu Ser Glu Val Gln Phe Leu Lys Gln 
     130                135                140
Glu Ile Ser Ser Leu Lys Asp Glu Leu Gln Thr Ala Leu Arg Asp Lys 
 145                150                155                160
Lys Phe Ala Ser Asp Lys Tyr Lys Asp Ile Tyr Thr Glu Leu Ser Ile 
                 165                170                175
Ala Lys Ala Lys Ala Asp Cys Asp Ile Ser Arg Leu Lys Glu Gln Leu 
             180                185                190
Lys Ala Ala Thr Glu Ala Leu Gly Glu Lys Ser Pro Glu Gly Thr Thr 
         195                200                205
Val Ser Gly Tyr Asp Ile Met Lys Ser Lys Ser Asn Pro Asp Phe Leu 
     210                215                220
Lys Lys Asp Arg Ser Cys Val Thr Arg Gln Leu Arg Asn Ile Arg Ser 
 225                230                235                240
Lys Ser Val Ile Glu Gln Val Ser Trp Asp Asn 
                 245                250



<210> 1889
<211> 1746
<212> DNA
<213> Rattus norvegicus
<308> D26154
<400> 1889

tccgcagct  taccgccta  tcttcctgg  tgtttgggc  gtttgattt  tttaaagat  60
ataagcatt  tccagttat  catcatgct  tatctatag  ctatgccat  tgacatatt  120
ggcaatgct  tattatgaa  acacatgta  acctctctg  aacctgtgt  taacccagc  180
tagttgtag  atgtggttg  attaatgaa  gttacaggc  aggggaccg  ctcctggct  240
aggagacag  tgccaccat  tcagccatt  aagccatga  gaatgctca  cgagaggag  300
tggaacggg  gttagagaa  agccagcgg  ctcagatca  cagcatcaa  tcagacata  360
aagccctga  gcgacagta  ctggaggag  tacagtcag  gcagcgaga  ctggaggtc  420
tttcggagc  gtactctca  aagtgtctg  agaatgcac  cctagccca  gcgctggaa  480
ctgagcggc  agccctgcg  cagtgtcag  gtgagaacc  agagctcaa  gcccacaac  540
aggagctga  taaccgcct  gctgcggag  tcacacggt  gcggacact  ctgactgga  600
aaggtggtg  ggaatccac  gggttggct  tcacacagg  caaggatgc  tatgagtta  660
aggtcttgt  gggggtcaa  gagtcagaa  ttcagttcc  gaaacagga  atcagctct  720
tcaaggatg  actccagac  gccctgcgg  ataagaagt  tgcgagcga  aagtacaaa  780
acatctaca  agagctcag  atcgcgaag  ccaaggctg  ctgtgacat  agcaggctg  840
aggagcagc  gaaagcagc  acagaggca  tgggcgaga  atctcctga  ggcactact  900
tgtcaggat  tgacataat  aaatctaaa  gcaatcctg  cttcctgaa  aaagacaga  960
cctgtgtta  ccggcaact  agaaacatc  ggtccaagt  cgtaattga  caggtctca  1020
gggataact  agtcgcgcc  gcttccaag  cccctgtcg  agtctgaag  aaggcctga  1080
ggtgcagga  cgcttgaag  tctttgaat  cagggactt  aagaaagat  agctgcatc  1140
attccactg  cacatcctt  ccagctggt  gcagcacaa  ccaagagtg  gtttcatct  1200
tgctttctc  ttgttgctg  cattaactg  gggtatgga  gcatgagag  ctgctgtgg  1260
gtgtttggt  cattccctc  ctgttaatt  caacttcct  ttgtcttta  cacagcttt  1320
ttcccatgg  attctcaga  tagtcacgc  aaagcagta  agtggggag  tgtccccac  1380
gacacctga  cagcccctt  tcctcccac  acactgtca  tattaaggc  caacagcct  1440
ttaataagc  agccctgcc  cggagtgca  gtgggggac  ggacctgtc  gtggctctg  1500
tctgccaca  acagcggag  accaccctt  ctgggtaga  cagacccca  cgaatgttc  1560
aggttgacc  ggtttctga  gggcctagg  tagtgtcca  cctggccca  ttccttttg  1620
tgtgggagg  ggacagcat  ttgtatttg  cccactaat  cagcttaga  ccataccca  1680
ataatcctg  caaatcttt  acgacctgg  aaatgttga  agcaaccat  cctattttg  1740
tttttt  1746



<210> 1890
<211> 251
<212> PRT
<213> Rattus norvegicus
<308> BAA05141
<400> 1890

Met Lys Asn Ala His Arg Glu Glu Met Glu Arg Glu Leu Glu Lys Ser 
  1               5                  10                  15
Gln Arg Ser Gln Ile Ser Ser Ile Asn Ser Asp Ile Glu Ala Leu Arg 
             20                  25                  30
Arg Gln Tyr Leu Glu Glu Leu Gln Ser Val Gln Arg Glu Leu Glu Val 
         35                  40                  45
Leu Ser Glu Gln Tyr Ser Gln Lys Cys Leu Glu Asn Ala His Leu Ala 
     50                  55                  60
Gln Ala Leu Glu Ala Glu Arg Gln Ala Leu Arg Gln Cys Gln Arg Glu 
 65                  70                  75                  80
Asn Gln Glu Leu Asn Ala His Asn Gln Glu Leu Asn Asn Arg Leu Ala 
                 85                  90                  95
Ala Glu Ile Thr Arg Leu Arg Thr Leu Leu Thr Gly Glu Gly Gly Gly 
             100                105                110
Glu Ser Thr Gly Leu Ala Leu Thr Gln Gly Lys Asp Ala Tyr Glu Leu 
         115                120                125
Glu Val Leu Leu Gly Val Asn Glu Ser Glu Val Gln Phe Leu Lys Gln 
     130                135                140
Glu Ile Ser Ser Leu Lys Asp Glu Leu Gln Thr Ala Leu Arg Asp Lys 
 145                150                155                160
Lys Phe Ala Ser Asp Lys Tyr Lys Asp Ile Tyr Thr Glu Leu Ser Ile 
                 165                170                175
Ala Lys Ala Lys Ala Asp Cys Asp Ile Ser Arg Leu Lys Glu Gln Leu 
             180                185                190
Lys Ala Ala Thr Glu Ala Leu Gly Glu Lys Ser Pro Glu Gly Thr Thr 
         195                200                205
Val Ser Gly Tyr Asp Ile Met Lys Ser Lys Ser Asn Pro Asp Phe Leu 
     210                215                220
Lys Lys Asp Arg Ser Cys Val Thr Arg Gln Leu Arg Asn Ile Arg Ser 
 225                230                235                240
Lys Ser Val Ile Glu Gln Val Ser Trp Asp Asn 
                 245                250



<210> 1891
<211> 1746
<212> DNA
<213> Rattus norvegicus
<308> D26154
<400> 1891

tccgcagct  taccgccta  tcttcctgg  tgtttgggc  gtttgattt  tttaaagat  60
ataagcatt  tccagttat  catcatgct  tatctatag  ctatgccat  tgacatatt  120
ggcaatgct  tattatgaa  acacatgta  acctctctg  aacctgtgt  taacccagc  180
tagttgtag  atgtggttg  attaatgaa  gttacaggc  aggggaccg  ctcctggct  240
aggagacag  tgccaccat  tcagccatt  aagccatga  gaatgctca  cgagaggag  300
tggaacggg  gttagagaa  agccagcgg  ctcagatca  cagcatcaa  tcagacata  360
aagccctga  gcgacagta  ctggaggag  tacagtcag  gcagcgaga  ctggaggtc  420
tttcggagc  gtactctca  aagtgtctg  agaatgcac  cctagccca  gcgctggaa  480
ctgagcggc  agccctgcg  cagtgtcag  gtgagaacc  agagctcaa  gcccacaac  540
aggagctga  taaccgcct  gctgcggag  tcacacggt  gcggacact  ctgactgga  600
aaggtggtg  ggaatccac  gggttggct  tcacacagg  caaggatgc  tatgagtta  660
aggtcttgt  gggggtcaa  gagtcagaa  ttcagttcc  gaaacagga  atcagctct  720
tcaaggatg  actccagac  gccctgcgg  ataagaagt  tgcgagcga  aagtacaaa  780
acatctaca  agagctcag  atcgcgaag  ccaaggctg  ctgtgacat  agcaggctg  840
aggagcagc  gaaagcagc  acagaggca  tgggcgaga  atctcctga  ggcactact  900
tgtcaggat  tgacataat  aaatctaaa  gcaatcctg  cttcctgaa  aaagacaga  960
cctgtgtta  ccggcaact  agaaacatc  ggtccaagt  cgtaattga  caggtctca  1020
gggataact  agtcgcgcc  gcttccaag  cccctgtcg  agtctgaag  aaggcctga  1080
ggtgcagga  cgcttgaag  tctttgaat  cagggactt  aagaaagat  agctgcatc  1140
attccactg  cacatcctt  ccagctggt  gcagcacaa  ccaagagtg  gtttcatct  1200
tgctttctc  ttgttgctg  cattaactg  gggtatgga  gcatgagag  ctgctgtgg  1260
gtgtttggt  cattccctc  ctgttaatt  caacttcct  ttgtcttta  cacagcttt  1320
ttcccatgg  attctcaga  tagtcacgc  aaagcagta  agtggggag  tgtccccac  1380
gacacctga  cagcccctt  tcctcccac  acactgtca  tattaaggc  caacagcct  1440
ttaataagc  agccctgcc  cggagtgca  gtgggggac  ggacctgtc  gtggctctg  1500
tctgccaca  acagcggag  accaccctt  ctgggtaga  cagacccca  cgaatgttc  1560
aggttgacc  ggtttctga  gggcctagg  tagtgtcca  cctggccca  ttccttttg  1620
tgtgggagg  ggacagcat  ttgtatttg  cccactaat  cagcttaga  ccataccca  1680
ataatcctg  caaatcttt  acgacctgg  aaatgttga  agcaaccat  cctattttg  1740
tttttt  1746



<210> 1892
<211> 251
<212> PRT
<213> Rattus norvegicus
<308> BAA05141
<400> 1892

Met Lys Asn Ala His Arg Glu Glu Met Glu Arg Glu Leu Glu Lys Ser 
  1               5                  10                  15
Gln Arg Ser Gln Ile Ser Ser Ile Asn Ser Asp Ile Glu Ala Leu Arg 
             20                  25                  30
Arg Gln Tyr Leu Glu Glu Leu Gln Ser Val Gln Arg Glu Leu Glu Val 
         35                  40                  45
Leu Ser Glu Gln Tyr Ser Gln Lys Cys Leu Glu Asn Ala His Leu Ala 
     50                  55                  60
Gln Ala Leu Glu Ala Glu Arg Gln Ala Leu Arg Gln Cys Gln Arg Glu 
 65                  70                  75                  80
Asn Gln Glu Leu Asn Ala His Asn Gln Glu Leu Asn Asn Arg Leu Ala 
                 85                  90                  95
Ala Glu Ile Thr Arg Leu Arg Thr Leu Leu Thr Gly Glu Gly Gly Gly 
             100                105                110
Glu Ser Thr Gly Leu Ala Leu Thr Gln Gly Lys Asp Ala Tyr Glu Leu 
         115                120                125
Glu Val Leu Leu Gly Val Asn Glu Ser Glu Val Gln Phe Leu Lys Gln 
     130                135                140
Glu Ile Ser Ser Leu Lys Asp Glu Leu Gln Thr Ala Leu Arg Asp Lys 
 145                150                155                160
Lys Phe Ala Ser Asp Lys Tyr Lys Asp Ile Tyr Thr Glu Leu Ser Ile 
                 165                170                175
Ala Lys Ala Lys Ala Asp Cys Asp Ile Ser Arg Leu Lys Glu Gln Leu 
             180                185                190
Lys Ala Ala Thr Glu Ala Leu Gly Glu Lys Ser Pro Glu Gly Thr Thr 
         195                200                205
Val Ser Gly Tyr Asp Ile Met Lys Ser Lys Ser Asn Pro Asp Phe Leu 
     210                215                220
Lys Lys Asp Arg Ser Cys Val Thr Arg Gln Leu Arg Asn Ile Arg Ser 
 225                230                235                240
Lys Ser Val Ile Glu Gln Val Ser Trp Asp Asn 
                 245                250



<210> 1893
<211> 2350
<212> DNA
<213> Rattus norvegicus
<308> D26178
<400> 1893

gggttcctg  tggatgcca  gcgctgccg  gtgtggact  gccgggttc  cccgctcgg  60
tcccactgc  cttgcctgc  gggcccgct  gggtgcacg  gccgcccgg  tgtgatcgc  120
gccagcaga  gactgatct  tgaaaatat  tatttggga  ataatcacg  tctgttgaa  180
actttgtgc  ggtgctgcc  tcgaaaaat  tggttacag  ccggggagg  ctgctacca  240
tgcaggact  aaccgcctc  gccctgaga  gagtgtccc  acagagcag  cgcaccatg  300
atagataca  aacgatcaa  cagcttggg  atgggacct  tggttctgt  ctgctgggg  360
gaagcattg  atctggaga  ctaattgcc  ttaaaaaaa  gaaaagaaa  ttttactcc  420
gggaagaat  catgaacct  cgggaggtt  agtctttaa  gaagctcaa  catgccaat  480
tagtgaagt  aaaagaggt  atcagggag  acgaccatc  ctatttcat  ttcgagtac  540
tgaaggaaa  cctttacca  ctcattaaa  aaagaaata  gttgttccc  gagtctgca  600
taaggaata  aatgtatca  atattgcaa  gactggcgt  cattcacaa  catggtttc  660
tccaccggg  cttaaagcc  gagaacctc  tctgcatgg  accagaact  gtgaaaatc  720
cggacttcg  attggcccg  gaaatccga  caagacctc  atacacaga  tatgtgtct  780
ctagatggt  tagggctcc  gaagtactc  tgagatcta  caactacag  tcccccatt  840
atgtctggg  cgtgggctg  atcatggca  aggtgtaca  cctccggcc  cttttccct  900
gggccagtg  aattgacac  attttcaaa  tttgccaag  gttgggaac  ccgaagaag  960
ctgactggc  tgaaggcta  cagctgtca  gtgctatga  tttcatctg  ccccagtgc  1020
tacccaata  cttaaagac  ctaattcca  atgctagca  cgaagcaat  cagctcctg  1080
gagacttgc  tcagtggga  cccaagaaa  gaccaactg  tagtcaggc  cttcgatac  1140
cttacttcc  gatcggaca  ccactgggc  tcagcacac  ggactcggg  aagccacag  1200
aagatgtcc  agacaagac  ggcccacct  cttacgtca  gccagcccc  cctgcccag  1260
ccccaacca  ggcgcatac  ctgatttct  cacgaccaa  ccaagccag  caaccccat  1320
agcattttg  atatcccta  aagggcgaa  cctctagga  agagcagct  agccacgtg  1380
aggagggcc  gccaaaccc  ccattcttc  cgtccctcc  caacaagaa  ctcccgcca  1440
aaatcctag  tggcctgga  cagaaaagc  gtgacatga  accaaagag  aggagaaga  1500
ggggtctca  ttccaggtc  accaagggt  ctgatgatt  ggccgactt  gctgactta  1560
atttcagtt  ctctctcac  agaatagat  tcaaaaaca  gaagagaca  agtgacgac  1620
ccctctgca  gtttgaaag  gttttggac  tgaagccat  tgagccggt  ggtacagga  1680
ctagtgtct  cacccaggc  tcctcccag  ggagagaca  gccgaccct  cagtccaca  1740
caaagcagc  ctacttgaa  cactctcgc  acctgcctg  aataaatat  agaaatggc  1800
tgctcccaa  tccaggcaa  gactttctt  catcaagtt  atggtccag  tctggtttg  1860
ctggaaaat  ttcaggaac  gtatcagta  tgagcaaaa  aacttcagt  ggctcaggc  1920
ccacgagct  tactggact  actggaagc  acatccctt  ctttctgaa  aaggaagtc  1980
gctctgtca  gcagagggt  cagctggcg  ctctcgcag  cccttcccc  ggctactct  2040
ccctcaagg  cgtgagacc  cacccaggg  ggccattct  tcacaccca  cctaggagc  2100
cgcctggct  gattccacg  cctccagct  tgcagcctg  gcacggcag  atagactgg  2160
cttccaagt  cccatctcg  cggtgactg  cccagctga  tccgttgta  ccccacaac  2220
acgtggcgg  gtaaaagca  ccacactta  agcagttct  aactaacac  tttcaatat  2280
tcttttaaa  gttttttta  acattgatt  gaatgcaat  ccctctttt  gtataaaat  2340
attttattct  2350



<210> 1894
<211> 629
<212> PRT
<213> Rattus norvegicus
<308> BAA05166
<400> 1894

Met Asn Arg Tyr Thr Thr Ile Lys Gln Leu Gly Asp Gly Thr Tyr Gly 
  1               5                  10                  15
Ser Val Leu Leu Gly Arg Ser Ile Glu Ser Gly Glu Leu Ile Ala Ile 
             20                  25                  30
Lys Lys Met Lys Arg Lys Phe Tyr Ser Trp Glu Glu Cys Met Asn Leu 
         35                  40                  45
Arg Glu Val Lys Ser Leu Lys Lys Leu Asn His Ala Asn Ile Val Lys 
     50                  55                  60
Leu Lys Glu Val Ile Arg Glu Asn Asp His Leu Tyr Phe Ile Phe Glu 
 65                  70                  75                  80
Tyr Met Lys Glu Asn Leu Tyr Gln Leu Ile Lys Glu Arg Asn Lys Leu 
                 85                  90                  95
Phe Pro Glu Ser Ala Ile Arg Asn Ile Met Tyr Gln Ile Leu Gln Gly 
             100                105                110
Leu Ala Phe Ile His Lys His Gly Phe Phe His Arg Asp Leu Lys Pro 
         115                120                125
Glu Asn Leu Leu Cys Met Gly Pro Glu Leu Val Lys Ile Ala Asp Phe 
     130                135                140
Gly Leu Ala Arg Glu Ile Arg Ser Arg Pro Pro Tyr Thr Asp Tyr Val 
 145                150                155                160
Ser Thr Arg Trp Tyr Arg Ala Pro Glu Val Leu Leu Arg Ser Thr Asn 
                 165                170                175
Tyr Ser Ser Pro Ile Asp Val Trp Ala Val Gly Cys Ile Met Ala Glu 
             180                185                190
Val Tyr Thr Leu Arg Pro Leu Phe Pro Gly Ala Ser Glu Ile Asp Thr 
         195                200                205
Ile Phe Lys Ile Cys Gln Val Leu Gly Thr Pro Lys Lys Thr Asp Trp 
     210                215                220
Pro Glu Gly Tyr Gln Leu Ser Ser Ala Met Asn Phe Ile Trp Pro Gln 
 225                230                235                240
Cys Ile Pro Asn Asn Leu Lys Thr Leu Ile Pro Asn Ala Ser Ser Glu 
                 245                250                255
Ala Ile Gln Leu Leu Arg Asp Leu Leu Gln Trp Asp Pro Lys Lys Arg 
             260                265                270
Pro Thr Ala Ser Gln Ala Leu Arg Tyr Pro Tyr Phe Gln Ile Gly His 
         275                280                285
Pro Leu Gly Ile Ser Thr Gln Asp Ser Gly Lys Pro Gln Lys Asp Val 
     290                295                300
Gln Asp Lys Thr Gly Pro Pro Pro Tyr Val Lys Pro Ala Pro Pro Ala 
 305                310                315                320
Gln Ala Pro Thr Lys Ala His Thr Leu Ile Ser Ser Arg Pro Asn Gln 
                 325                330                335
Ala Ser Gln Pro His Gln His Phe Val Tyr Pro Tyr Lys Gly Glu Ala 
             340                345                350
Ser Arg Thr Glu Gln Leu Ser His Val Gln Glu Gly Gln Pro Asn Pro 
         355                360                365
Pro Phe Phe Pro Ser Leu His Asn Lys Asn Leu Pro Pro Lys Ile Leu 
     370                375                380
Ala Gly Leu Glu Gln Lys Ser Gly Asp Met Lys Pro Lys Ser Arg Arg 
 385                390                395                400
Arg Trp Gly Leu Ile Ser Arg Ser Thr Lys Gly Ser Asp Asp Trp Ala 
                 405                410                415
Asp Leu Ala Asp Leu Asp Phe Ser Ser Ser Leu Thr Arg Ile Asp Val 
             420                425                430
Lys Asn Lys Lys Arg Gln Ser Asp Asp Pro Leu Cys Arg Phe Glu Ser 
         435                440                445
Val Leu Asp Leu Lys Pro Ser Glu Pro Val Gly Thr Gly Thr Ser Val 
     450                455                460
Ser Thr Gln Ala Ser Ser Gln Arg Arg Asp Thr Pro Thr Leu Gln Ser 
 465                470                475                480
Thr Ala Lys Gln His Tyr Leu Lys His Ser Arg Tyr Leu Pro Gly Ile 
                 485                490                495
Asn Ile Arg Asn Gly Val Leu Pro Asn Pro Gly Lys Asp Phe Leu Pro 
             500                505                510
Ser Ser Ser Trp Ser Ser Ser Gly Leu Ser Gly Lys Ser Ser Gly Thr 
         515                520                525
Val Ser Val Val Ser Lys Ile Thr Ser Val Gly Ser Gly Ser Thr Ser 
     530                535                540
Ser Thr Gly Leu Thr Gly Ser Tyr Ile Pro Ser Phe Leu Lys Lys Glu 
 545                550                555                560
Val Gly Ser Val Met Gln Arg Val Gln Leu Ala Pro Leu Ala Ala Pro 
                 565                570                575
Ser Pro Gly Tyr Ser Ser Leu Lys Ala Val Arg Pro His Pro Gly Arg 
             580                585                590
Pro Phe Phe His Thr Gln Pro Arg Ser Thr Pro Gly Leu Ile Pro Arg 
         595                600                605
Pro Pro Ala Val Gln Pro Val His Gly Arg Ile Asp Trp Ser Ser Lys 
     610                615                620
Tyr Pro Ser Arg Arg 
 625



<210> 1895
<211> 6014
<212> DNA
<213> Homo sapiens
<308> NM_014920
<400> 1895

cccatttcc  gctccggag  gggcggctg  gccccgctc  tcgaggagc  gcgctcacc  60
caggggcgg  cccccgcct  cgttcgcgg  gccagcaga  gactgattt  tggaaatat  120
tatttggga  acagtcacg  cctattgaa  accttgtgc  ggtgctgcc  tcgaaaaat  180
tggttacac  ctggggagg  ctgctacca  tgcagaact  aaccacttc  gccgtgaga  240
gagtgtccg  cctgagcag  cacaccatg  atagataca  aacaatcag  cagctcggg  300
atggaacct  cggttccgt  ctgctggga  gaagcattg  gtctgggga  ctgatcgct  360
ttaaaaaaa  gaaaagaaa  ttttattcc  gggaggaat  catgaacct  cgggaggtt  420
agtctttaa  gaagctcaa  catgccaat  tagtcaaat  aaaagaagt  atcagggaa  480
atgatcatc  ttattttat  ttcgagtac  tgaaggaaa  tctttacca  ctcattaaa  540
agagaaata  gttgtttcc  gagtctgct  taaggaata  catgtatca  atattacaa  600
gactcgcat  tattcacaa  cacggcttc  ttcatcgag  cttaaagcc  gagaacctc  660
tctgcatgg  accagaact  gtgaaaatt  cagactttg  tttggcccg  gaaatacga  720
caaaacctc  atatacaga  tatgtatct  ccagatggt  cagggctcc  gaagtactc  780
tgaggtcta  caactacag  tcccccatt  acgtctggg  ggtgggctg  atcatggca  840
aagtttaca  cctcaggcc  ctcttccct  gagccagtg  aattgacac  atattcaaa  900
tttgccaag  gctggggac  ccaaaaaag  ctgactggc  tgaaggcta  caactttca  960
gtgcaatga  cttccgttg  ccacagtgt  tacccaata  cttaaagac  ttgattccc  1020
atgctagca  tgaagcagt  cagctcctg  gagacatgc  tcagtggga  cccaagaaa  1080
gaccaacag  tagtcaggc  cttcgatat  cttacttcc  agttggaca  ccactaggc  1140
gcaccacac  aaaccttca  gattcagaa  aaccacaga  aggcatcct  gaaaaggca  1200
gcccacctc  ttatattaa  ccagtccca  ctgcccagc  accagccaa  ccacacaca  1260
gaatttctt  acgacagca  caagccagc  agccccctc  gcatctcac  tacccctac  1320
aagcagagg  ctccaggac  gatcaccca  gccatctcc  ggaggacaa  ccaagcccg  1380
tgcttttcc  atccctcca  aacaagcat  cacagtcga  aatcacagc  ggcctggag  1440
acaaaaatg  tgagataaa  ccaaagagt  ggagaaggt  gggtcttat  tccaggtca  1500
caaaggatt  agatgattg  gctgacttg  atgacttgg  tttcagtcc  tccctcagc  1560
ggattgacc  gaaaaacaa  aaaagacag  gtgatgaca  tctctgcag  tttgagagt  1620
ttttggacc  gaagccctc  gagcctgtg  gcacaggaa  cagtgcccc  acccagacg  1680
catatcagc  gcgagacac  cccaccctg  gatctgcag  caagcagca  tatttgaag  1740
actctcgat  cttgcctgg  atcagtata  gaaatggca  actctcgaa  ccaggcaag  1800
aatttattc  acctaatcc  tggtctagt  ctggcttgt  tggaaaatc  tcagggaca  1860
tgtcagtaa  cagcaaagt  aattcagtt  gttccagct  tacaagttc  agtggactg  1920
ctggaaact  tgtcccttc  tttctgaaa  aagaaatcg  ttctgctat  cagagggta  1980
acctagcac  tattccaga  ccttcccct  gttattcct  cctgaaggc  atgagacct  2040
atcctgggc  accattctt  cacacccag  ctagaagca  tcctgggtt  ataccacgg  2100
ctccagccg  ccagccagt  catggccgg  cagactggg  ttccaagta  gcatctcgg  2160
gatgactgt  tgccttggt  atgaatctc  tcctaggga  aagcaggat  ctttccctc  2220
gctgactgg  gttctacct  caagatgtg  agagggcat  aaagcaaat  aacacttta  2280
agttattct  ctgaactaa  acatgtcaa  attcttttt  aaagttttt  tttaaaata  2340
tgatttgaa  gcagtaggc  tttttgtat  aaattattt  attctaaaa  tgggtccca  2400
tattttctt  aacaacagc  ttttgtata  atggattat  ttttagcat  ttatacagt  2460
aactttgta  tgaactttt  aaaaattaa  tgattttcc  ttggggttc  agataatat  2520
ttctacaga  tttgaaaaa  gtaataata  taatgcagt  ttgcaacag  ggtgcaatt  2580
aaggctatg  gatagaggg  tatttactc  gtgtgtgca  atatttatg  agtggtgaa  2640
tttcaagtg  ggctcacta  gtacttcag  ccttcttgg  ctgttgtta  aaaagtgat  2700
ctctgcttt  cttagtagg  cattggttt  atttttgga  accactctg  tgttctaaa  2760
ggactatta  attatataa  tcactttgt  ttacttttg  tccccagat  aaagaactc  2820
aagtaaata  attttaaaa  atttttctg  cacccttta  tgtggttgc  gatctcaga  2880
gaaaccaag  ttaattata  tatgccatt  tattctaat  tattccatt  ttgaaatca  2940
gttgtatgt  taccaataa  agagatttc  gcttcaaaa  gctctcaac  tgaaggtta  3000
cacagtcaa  caaacttac  ttcctgcca  gatgcatgg  caaaaaact  agtatcaaa  3060
cagcagaag  tttttgatt  tagtaactg  gatggaatt  tgtgcctag  tcagttctc  3120
agatctggc  aggagcagt  aatgactaa  gttctgtcc  agccaaatt  tcaggacaa  3180
ttggggagc  gaaagagtt  tggcagagg  tccactcat  tacaaagtc  cagtcacat  3240
ccacatttg  tctcctaac  ctggtgtag  ttctttcaa  agtgagaac  ttatttgtt  3300
ggcagaggc  gttccattg  gaggaatgt  tacagcagt  tcaaaaatg  caaagtcag  3360
ttggagaca  aaaaagaca  aaggtccag  ctcatccat  tctatatgg  acatttgcc  3420
cacttatgg  tgccttaaa  gcaagaggg  aggtcacca  cagtgaacg  aatgcaatc  3480
caacagtgt  ttgattcat  ttctcctag  gctcaaact  ctctctatt  gttccagga  3540
aatgacaaa  tgaaccata  gtaagtaat  ttttatttt  tattttttt  ttgagacag  3600
gtctcactc  gtcacccag  ctggagtgc  gtggcgcga  cttagctct  tgcaacctc  3660
gcctcccag  ttcaagcct  ctgagtaac  gggactaca  gcgcccgcc  ccacgccca  3720
ctaattttt  gtattttta  tagagacgg  gtttcactg  gttagccag  acggcctcg  3780
tctcctgac  tcgtgatcc  ccctcctcc  cctcccaaa  tactgggat  acaggcatg  3840
gccactgca  ccagccaag  gatcatttt  ataggttaa  atgataggt  aaatgaata  3900
agacacttt  atatggttc  acctaatga  ttggtaaat  attgccttg  tgtattaat  3960
atatgttgc  ttctgaaca  ataaccatg  cttccaaag  gccctaacc  aaaatcgga  4020
agtaattta  gctttggag  atttgactc  aatatatac  tgaccaagc  ccatgatcc  4080
taggggcat  agaaaagca  ataatggat  tggatgtga  aggtggtct  ttcctgtta  4140
caagctggc  gcaaagctt  agaaaatat  tatgcaagc  caacttgaa  ctgaattca  4200
ttctgtatt  tattctcaa  tcgttatct  aagcatcag  acatgtgtt  tcagagatg  4260
gtcctttac  ataaggtta  tatttattt  cattttctg  attatatat  aaaagtaaa  4320
taatgtgaa  cctggccca  cttgctgga  agcaggttt  aaattgtaa  tattcctta  4380
aggagcaaa  ggattgttt  ataccatag  ctcagtaat  tagcttata  aaggtcatt  4440
catttttta  ctgaaaaac  tagttacct  attattgca  attataaaa  tgtttttct  4500
atactttat  gggcccaac  tcagaaaat  cttcgcttt  ttcttttta  gctttcgtt  4560
gtttaccag  aagcaactt  cctggggaa  ccaaacaca  attcataaa  aaaatcaag  4620
agctgatgt  cagttgaga  aactagagg  ctgaaaaaa  aaattttaa  tagcaaatg  4680
tgtgaatta  tcttcctcc  cttctctga  atgggtaaa  gacaaattg  gtaaaaaaa  4740
ctatgcact  tagaaggga  tagtaacca  ttcttttgt  tctctgttt  tgttctgac  4800
gagaacctg  agccatttc  tgttacatg  aaacaaaat  ctacttgtt  cctctattt  4860
ttgttacta  acaattatg  aatgtaatg  aagacacca  cagaaatga  atacctgta  4920
ctgtaccta  caggactat  cctcattta  agtcagaaa  cttactggg  tgtcaggaa  4980
tgatacagg  ttggttctc  tttcgtgcc  aaatgagac  gaaattcag  gacgaaggt  5040
cgttgtagg  gtattgatg  gccccaggt  gtgccagca  agtagggaa  actgcattt  5100
cataaaaac  actcttgac  tgattgttc  ttttacaaa  aaattccat  aattaccaa  5160
ccctcaccc  gcccatgtg  gataggatt  atgtaggaa  aaacttgat  ttcaaataa  5220
tttttaaat  tatctcttg  ctaaaggac  atatacatc  aataaagta  cactgtgtc  5280
tcttctgga  ttatcaaaa  ttgtataca  tcaagacaa  acaagaatt  ttttatttt  5340
gagtgcaaa  acaggtact  ttggagttg  tgggcacca  gctttctca  gaagtagca  5400
ttccctacc  tcaagccat  gttttgtgc  attcaggag  ggaaaaaaa  gaatttatg  5460
tgtacattt  agttcagtg  atgaccaaa  gcaatatgt  tataagaag  tgtttgaca  5520
actaattat  ttatatcat  taaaccata  tgtagcaac  taatatatg  agctaattt  5580
tagaattat  tttacgatt  ccaaacaaa  gtactgtac  gttatataa  ttattgtga  5640
gaccttctc  tggaagcca  taggaaaac  aactagagg  aaatatcac  ttaatctgt  5700
ttatcaatt  ctcatagac  ctgtgctaa  gtgaatttt  aatgacctg  atcaagtct  5760
ctgatctca  ataactcag  acagatagc  attagtcag  tgatttgat  acaatggag  5820
aaccgacaa  atatttatt  ataaagcac  tattcataa  aacgagaag  attcagaaa  5880
ccacttaag  aagaccctt  tgaaataaa  aatgttgct  tttaaatag  ttgtcctaa  5940
gtgtttaaa  catgtcaac  ttatgtaag  aaaaatttc  tggtccaaa  aaagttgaa  6000
tttaagaaa  attg  6014



<210> 1896
<211> 632
<212> PRT
<213> Homo sapiens
<308> NP_055735
<400> 1896

Met Asn Arg Tyr Thr Thr Ile Arg Gln Leu Gly Asp Gly Thr Tyr Gly 
  1               5                  10                  15
Ser Val Leu Leu Gly Arg Ser Ile Glu Ser Gly Glu Leu Ile Ala Ile 
             20                  25                  30
Lys Lys Met Lys Arg Lys Phe Tyr Ser Trp Glu Glu Cys Met Asn Leu 
         35                  40                  45
Arg Glu Val Lys Ser Leu Lys Lys Leu Asn His Ala Asn Val Val Lys 
     50                  55                  60
Leu Lys Glu Val Ile Arg Glu Asn Asp His Leu Tyr Phe Ile Phe Glu 
 65                  70                  75                  80
Tyr Met Lys Glu Asn Leu Tyr Gln Leu Ile Lys Glu Arg Asn Lys Leu 
                 85                  90                  95
Phe Pro Glu Ser Ala Ile Arg Asn Ile Met Tyr Gln Ile Leu Gln Gly 
             100                105                110
Leu Ala Phe Ile His Lys His Gly Phe Phe His Arg Asp Leu Lys Pro 
         115                120                125
Glu Asn Leu Leu Cys Met Gly Pro Glu Leu Val Lys Ile Ala Asp Phe 
     130                135                140
Gly Leu Ala Arg Glu Ile Arg Ser Lys Pro Pro Tyr Thr Asp Tyr Val 
 145                150                155                160
Ser Thr Arg Trp Tyr Arg Ala Pro Glu Val Leu Leu Arg Ser Thr Asn 
                 165                170                175
Tyr Ser Ser Pro Ile Asp Val Trp Ala Val Gly Cys Ile Met Ala Glu 
             180                185                190
Val Tyr Thr Leu Arg Pro Leu Phe Pro Gly Ala Ser Glu Ile Asp Thr 
         195                200                205
Ile Phe Lys Ile Cys Gln Val Leu Gly Thr Pro Lys Lys Thr Asp Trp 
     210                215                220
Pro Glu Gly Tyr Gln Leu Ser Ser Ala Met Asn Phe Arg Trp Pro Gln 
 225                230                235                240
Cys Val Pro Asn Asn Leu Lys Thr Leu Ile Pro Asn Ala Ser Ser Glu 
                 245                250                255
Ala Val Gln Leu Leu Arg Asp Met Leu Gln Trp Asp Pro Lys Lys Arg 
             260                265                270
Pro Thr Ala Ser Gln Ala Leu Arg Tyr Pro Tyr Phe Gln Val Gly His 
         275                280                285
Pro Leu Gly Ser Thr Thr Gln Asn Leu Gln Asp Ser Glu Lys Pro Gln 
     290                295                300
Lys Gly Ile Leu Glu Lys Ala Gly Pro Pro Pro Tyr Ile Lys Pro Val 
 305                310                315                320
Pro Pro Ala Gln Pro Pro Ala Lys Pro His Thr Arg Ile Ser Ser Arg 
                 325                330                335
Gln His Gln Ala Ser Gln Pro Pro Leu His Leu Thr Tyr Pro Tyr Lys 
             340                345                350
Ala Glu Val Ser Arg Thr Asp His Pro Ser His Leu Gln Glu Asp Lys 
         355                360                365
Pro Ser Pro Leu Leu Phe Pro Ser Leu His Asn Lys His Pro Gln Ser 
     370                375                380
Lys Ile Thr Ala Gly Leu Glu His Lys Asn Gly Glu Ile Lys Pro Lys 
 385                390                395                400
Ser Arg Arg Arg Trp Gly Leu Ile Ser Arg Ser Thr Lys Asp Ser Asp 
                 405                410                415
Asp Trp Ala Asp Leu Asp Asp Leu Asp Phe Ser Pro Ser Leu Ser Arg 
             420                425                430
Ile Asp Leu Lys Asn Lys Lys Arg Gln Ser Asp Asp Thr Leu Cys Arg 
         435                440                445
Phe Glu Ser Val Leu Asp Leu Lys Pro Ser Glu Pro Val Gly Thr Gly 
     450                455                460
Asn Ser Ala Pro Thr Gln Thr Ser Tyr Gln Arg Arg Asp Thr Pro Thr 
 465                470                475                480
Leu Arg Ser Ala Ala Lys Gln His Tyr Leu Lys His Ser Arg Tyr Leu 
                 485                490                495
Pro Gly Ile Ser Ile Arg Asn Gly Ile Leu Ser Asn Pro Gly Lys Glu 
             500                505                510
Phe Ile Pro Pro Asn Pro Trp Ser Ser Ser Gly Leu Ser Gly Lys Ser 
         515                520                525
Ser Gly Thr Met Ser Val Ile Ser Lys Val Asn Ser Val Gly Ser Ser 
     530                535                540
Ser Thr Ser Ser Ser Gly Leu Thr Gly Asn Tyr Val Pro Ser Phe Leu 
 545                550                555                560
Lys Lys Glu Ile Gly Ser Ala Met Gln Arg Val His Leu Ala Pro Ile 
                 565                570                575
Pro Asp Pro Ser Pro Gly Tyr Ser Ser Leu Lys Ala Met Arg Pro His 
             580                585                590
Pro Gly Arg Pro Phe Phe His Thr Gln Pro Arg Ser Thr Pro Gly Leu 
         595                600                605
Ile Pro Arg Pro Pro Ala Ala Gln Pro Val His Gly Arg Thr Asp Trp 
     610                615                620
Ala Ser Lys Tyr Ala Ser Arg Arg 
 625                630



<210> 1897
<211> 3035
<212> DNA
<213> Rattus norvegicus
<308> D26180
<400> 1897

gaattccgc  gagcgcagc  ggccggatc  cgcagcgcg  cagggaagg  ctgggctcc  60
cgcttcccg  cccacacgc  gacgcgctc  caagccctc  ctcggcgct  ggacccctg  120
cggacatgg  cggcgacgc  gtgcagagt  aacctcgca  ctggtcact  ctggagcag  180
tgggtctgg  tggggcaga  ctggcagcc  ctggggtgc  gcagcagct  gagttagag  240
gagagcggc  gaagcggga  atccgaaaa  agctgaagc  gaaggaggg  gctgagaac  300
tgaggcggg  caccactga  ctgggccgc  gcttggccc  tgtggaact  ctgctgagg  360
gctccgcta  acggcttga  ttgctgcac  agcagctgc  ggagctgca  gcacatgtg  420
tgctgcccg  ccctacagc  gggagtgat  ctccccaat  ccttgcaga  ggcagccct  480
tctgctcat  caccaacct  agccgagtg  ctggcctgg  gaagcagct  gccattgag  540
tcaaggtca  acagggggc  gaaaacatg  tccagacct  cagcaatgg  agcaccaag  600
accggaagc  gctgttgac  gcccaacag  tgctgcagg  tagtaagac  aagattgac  660
tcatccgca  gcagcttcg  cgggcgcta  aagcactcc  ggctggcca  ctggagagt  720
aggcagctc  tgatgaggc  cacggagat  cagacctgg  agccgtaga  ctacgcatt  780
aggagctac  acaccattt  cgagtagag  atgcagtgg  agaaggcgc  aagaatgtc  840
tgcgtctgc  cagtgctgc  aaggcccca  accgcaaag  agtcagcga  gctcaggag  900
aattgactg  gtccaacca  aagctgggc  tgctgcggg  gtcactgga  aggcgcttg  960
gggaactgc  tgctgatca  cccaaggga  gcctgcttc  ggaggagct  actgcggcc  1020
catcggcag  cttcagtgc  atactgcct  ggcccttcc  tgccactca  tacagcacc  1080
tgagcaagc  tgcaccact  acagggacc  tggaagtac  agtggtggg  tgcaaaaac  1140
ttcccgaga  catcccttg  agccctccc  cctcagtcg  ggcatctgg  acccccgac  1200
gccgcactc  tttcctgag  cgtccagct  ggggccttt  caaccgaag  ggaagcctt  1260
gtggacgga  cagcctcaa  ggggaggca  agaattcca  tgaggtcag  accgtgctc  1320
agctggaca  cactgtggt  gggcaaaca  cctggaagc  atgcggccc  aatgcctgg  1380
accagagct  caccctgga  ctggagagg  ctcgggagc  ggagttggc  gtgttctgg  1440
gtgaccaga  gggtctgtg  gctctcaaa  ttctgaagt  ggaagactt  ttggacaat  1500
agaggcatg  ggtgcagct  gacatggaa  cccagggct  cctggtggc  gaggtcacc  1560
tccgtaacc  catcatcga  cggatccct  ggctccaaa  gcagaaaaa  attttctcc  1620
agcagcaag  gcagacatt  cagcgtgcc  gacacatga  catcgatgt  gccacctgg  1680
tgcggctgc  ccggagact  atcccgaac  ccgtggcca  tggctcctt  agccccaat  1740
catctccag  ctctgagat  cggagcact  gagacatat  catggagaa  ttgaatctc  1800
gtgctgact  agacagctc  tcccagaag  gccccgcag  gctgccctc  acctcatgt  1860
gcctgagtt  tccaaccca  gaatccacc  cctctccag  gctgccttc  gagacccag  1920
agaccccag  ccctggcct  tgcagtccc  tgaggaagt  gcccctgac  cttgaggac  1980
tcaagttcc  ggcagtgct  ggtcggggt  actttggaa  ggtgctgct  tctgaattc  2040
actccagtg  ggagctctt  gccattaaa  ccttgaaga  aggtgacat  gtagcccgg  2100
atgaggttg  gagcctgat  tgtgagaag  ggattttgg  gaccgtgac  agggcagga  2160
atcccttcc  tgtgaacct  ttcggctgt  tccagaccc  agagcatgt  tgctttgtg  2220
tggagtact  agccggtgg  gacttgatg  tgcatatcc  cagcgacgt  ttctcagag  2280
ctcgggctg  cttctattc  gcctgtgtg  tgctgggac  gcagttcct  catgaacac  2340
agattgtct  cagggacct  aagttggac  atttgctcc  ggatactga  ggctacgtc  2400
agatcgcag  ctttggcct  tgcaaggag  ggatgggct  tggggaccg  accagcaca  2460
tctgcggaa  tccggagtt  ctggcgccg  aagtgctca  agacacatc  tacactcga  2520
ccgtggact  gtggggact  ggtgtattt  tctatgaga  gctggttgg  gagtctccg  2580
tccctgggg  cgacgagga  gaagtattt  acagcatcg  caatgatga  gttcgttat  2640
cccgcttcc  gtctgcgga  gccatcggc  tcatgagaa  gctactgcg  aggaaccca  2700
agcggaggt  gggatccac  gagcgtgat  cagaagatg  gaaaaaaca  cctttcttc  2760
ggactctgg  ctgggatgc  ctgctggcc  gtcgcctgc  tccaccctt  gtgcctaca  2820
tttcggggc  cacagacgt  agcaacttc  atgaggagt  cactgggga  gcccccaca  2880
tgagccctc  ccgggatgc  cggcccctg  cagctgcgg  gcaggcggc  ttccgggat  2940
tcgactttg  ggcaggagg  tattagccc  aagcccctg  cttgcccaa  agttcttgg  3000
ttttaaaaa  gcctttggg  tttactccg  aattc  3035



<210> 1898
<211> 946
<212> PRT
<213> Rattus norvegicus
<308> Q63433
<400> 1898

Met Ala Gly Asp Ala Val Gln Ser Glu Pro Arg Ser Trp Ser Leu Leu 
  1               5                  10                  15
Glu Gln Leu Gly Leu Ala Gly Ala Asp Leu Ala Ala Pro Gly Val Gln 
             20                  25                  30
Gln Gln Leu Glu Leu Glu Arg Glu Arg Leu Lys Arg Glu Ile Arg Lys 
         35                  40                  45
Glu Leu Lys Leu Lys Glu Gly Ala Glu Asn Leu Arg Arg Ala Thr Thr 
     50                  55                  60
Asp Leu Gly Arg Ser Leu Ala Pro Val Glu Leu Leu Leu Arg Gly Ser 
 65                  70                  75                  80
Ala Arg Arg Leu Asp Leu Leu His Gln Gln Leu Gln Glu Leu His Ala 
                 85                  90                  95
His Val Val Leu Pro Asp Pro Thr Ala Gly Ser Asp Ala Pro Gln Ser 
             100                105                110
Leu Ala Glu Gly Ser Pro Val Cys Ser Ser Thr Asn Leu Ser Arg Val 
         115                120                125
Ala Gly Leu Glu Lys Gln Leu Ala Ile Glu Leu Lys Val Lys Gln Gly 
     130                135                140
Ala Glu Asn Met Ile Gln Thr Tyr Ser Asn Gly Ser Thr Lys Asp Arg 
 145                150                155                160
Lys Leu Leu Leu Thr Ala Gln Gln Met Leu Gln Asp Ser Lys Thr Lys 
                 165                170                175
Ile Asp Ile Ile Arg Met Gln Leu Arg Arg Ala Leu Gln Ala Leu Gln 
             180                185                190
Ala Gly Gln Leu Glu Ser Gln Ala Ala Pro Asp Glu Ala His Gly Asp 
         195                200                205
Pro Asp Leu Gly Ala Val Glu Leu Arg Ile Glu Glu Leu Arg His His 
     210                215                220
Phe Arg Val Glu His Ala Val Ala Glu Gly Ala Lys Asn Val Leu Arg 
 225                230                235                240
Leu Leu Ser Ala Ala Lys Ala Pro Asp Arg Lys Ala Val Ser Glu Ala 
                 245                250                255
Gln Glu Lys Leu Thr Glu Ser Asn Gln Lys Leu Gly Leu Leu Arg Glu 
             260                265                270
Ser Leu Glu Arg Arg Leu Gly Glu Leu Pro Ala Asp His Pro Lys Gly 
         275                280                285
Arg Leu Leu Arg Glu Glu Leu Thr Ala Ala Ser Ser Ala Ala Phe Ser 
     290                295                300
Ala Ile Leu Pro Gly Pro Phe Pro Ala Thr His Tyr Ser Thr Leu Ser 
 305                310                315                320
Lys Pro Ala Pro Leu Thr Gly Thr Leu Glu Val Arg Val Val Gly Cys 
                 325                330                335
Lys Asn Leu Pro Glu Thr Ile Pro Trp Ser Pro Pro Pro Ser Val Gly 
             340                345                350
Ala Ser Gly Thr Pro Asp Ser Arg Thr Pro Phe Leu Ser Arg Pro Ala 
         355                360                365
Arg Gly Leu Tyr Asn Arg Ser Gly Ser Leu Ser Gly Arg Ser Ser Leu 
     370                375                380
Lys Gly Glu Ala Glu Asn Ser Thr Glu Val Ser Thr Val Leu Lys Leu 
 385                390                395                400
Asp Asn Thr Val Val Gly Gln Thr Ala Trp Lys Pro Cys Gly Pro Asn 
                 405                410                415
Ala Trp Asp Gln Ser Phe Thr Leu Glu Leu Glu Arg Ala Arg Glu Leu 
             420                425                430
Glu Leu Ala Val Phe Trp Arg Asp Gln Arg Gly Leu Cys Ala Leu Lys 
         435                440                445
Phe Leu Lys Leu Glu Asp Phe Leu Asp Asn Glu Arg His Glu Val Gln 
     450                455                460
Leu Asp Met Glu Pro Gln Gly Cys Leu Val Ala Glu Val Thr Phe Arg 
 465                470                475                480
Asn Pro Ile Ile Glu Arg Ile Pro Arg Leu Gln Arg Gln Lys Lys Ile 
                 485                490                495
Phe Ser Lys Gln Gln Gly Gln Thr Phe Gln Arg Ala Arg His Met Asn 
             500                505                510
Ile Asp Val Ala Thr Trp Val Arg Leu Leu Arg Arg Leu Ile Pro Asn 
         515                520                525
Ala Val Ala Thr Gly Ser Phe Ser Pro Asn Ala Ser Pro Gly Ser Glu 
     530                535                540
Ile Arg Ser Thr Gly Asp Ile Ser Met Glu Lys Leu Asn Leu Gly Ala 
 545                550                555                560
Asp Ser Asp Ser Ser Ser Gln Lys Ser Pro Ala Gly Leu Pro Ser Thr 
                 565                570                575
Ser Cys Ser Leu Ser Ser Pro Thr His Glu Ser Thr Thr Ser Pro Glu 
             580                585                590
Leu Pro Ser Glu Thr Gln Glu Thr Pro Gly Pro Gly Leu Cys Ser Pro 
         595                600                605
Leu Arg Lys Ser Pro Leu Thr Leu Glu Asp Phe Lys Phe Leu Ala Val 
     610                615                620
Leu Gly Arg Gly His Phe Gly Lys Val Leu Leu Ser Glu Phe His Ser 
 625                630                635                640
Ser Gly Glu Leu Phe Ala Ile Lys Ala Leu Lys Lys Gly Asp Ile Val 
                 645                650                655
Ala Arg Asp Glu Val Glu Ser Leu Met Cys Glu Lys Arg Ile Leu Ala 
             660                665                670
Thr Val Thr Arg Ala Gly His Pro Phe Leu Val Asn Leu Phe Gly Cys 
         675                680                685
Phe Gln Thr Pro Glu His Val Cys Phe Val Met Glu Tyr Ser Ala Gly 
     690                695                700
Gly Asp Leu Met Leu His Ile His Ser Asp Val Phe Ser Glu Pro Arg 
 705                710                715                720
Ala Gly Phe Tyr Ser Ala Cys Val Val Leu Gly Leu Gln Phe Leu His 
                 725                730                735
Glu His Lys Ile Val Tyr Arg Asp Leu Lys Leu Asp Asn Leu Leu Leu 
             740                745                750
Asp Thr Glu Gly Tyr Val Lys Ile Ala Asp Phe Gly Leu Cys Lys Glu 
         755                760                765
Gly Met Gly Tyr Gly Asp Arg Thr Ser Thr Phe Cys Gly Thr Pro Glu 
     770                775                780
Phe Leu Ala Pro Glu Val Leu Thr Asp Thr Ser Tyr Thr Arg Ala Val 
 785                790                795                800
Asp Trp Trp Gly Leu Gly Val Phe Leu Tyr Glu Met Leu Val Gly Glu 
                 805                810                815
Ser Pro Phe Pro Gly Asp Asp Glu Glu Glu Val Phe Asp Ser Ile Val 
             820                825                830
Asn Asp Glu Val Arg Tyr Pro Arg Phe Leu Ser Ala Glu Ala Ile Gly 
         835                840                845
Ile Met Arg Arg Leu Leu Arg Arg Asn Pro Glu Arg Arg Leu Gly Ser 
     850                855                860
Thr Glu Arg Asp Ala Glu Asp Val Lys Lys Gln Pro Phe Phe Arg Thr 
 865                870                875                880
Leu Asp Trp Asp Ala Leu Leu Ala Arg Arg Leu Pro Pro Pro Phe Val 
                 885                890                895
Pro Thr Leu Ser Gly Arg Thr Asp Val Ser Asn Phe Asp Glu Glu Phe 
             900                905                910
Thr Gly Glu Ala Pro Thr Leu Ser Pro Pro Arg Asp Ala Arg Pro Leu 
         915                920                925
Thr Ala Ala Glu Gln Ala Ala Phe Arg Asp Phe Asp Phe Val Ala Gly 
     930                935                940
Gly Tyr 
 945



<210> 1899
<211> 2965
<212> DNA
<213> Homo sapiens
<308> XM_031273
<400> 1899

acgcgcgct  ctctggccg  ccctccctc  gcgcgggga  ccctggcgg  cggcaggag  60
acatggcca  cgacgccgt  cagagtgag  ctcgcagct  gtccctgct  gagcagctg  120
gcctggccg  ggcagacct  gcggccccc  gggtacagc  gcagctgga  ctggagcgg  180
agcggctgc  gcgggaaat  cgcaaggag  tgaagctga  ggagggtgc  gagaacctg  240
ggcgggcca  cactgacct  ggccgcagc  tgggccccg  agagctgct  ctgcggggc  300
cctcgcgcc  cctcgacct  ctgcaccag  agctgcagg  gctgcacgc  cacgtggtg  360
ttcccgacc  ggcggccac  cacgatggc  cccagtccc  tggtgcggg  ggccccacc  420
gctcggcca  caacctgag  cgcgtggcg  gcctggaga  gcagttggc  attgagctg  480
aggtgaagc  gggggcgga  aacatgatc  agacctaca  caatggcag  accaaggac  540
ggaagctgc  gctgacagc  cagcagatg  tgcaggaca  taagaccaa  attgacatc  600
tccgcatgc  actccgccg  gcgctgcag  ccggccagc  ggagaacca  gcagccccg  660
atgacaccc  agggagtcc  gacctgggg  ctgtggagc  gcgcatcga  gagctgcgg  720
accacttcc  agtggagca  gcggtggcc  agggtgcca  gaacgtact  cgcctgctc  780
gcgctgcca  ggccccgga  cgcaaggca  tcagcgagg  ccaggagaa  ttaacagaa  840
ccaaccaga  gctggggct  ctgcgggag  ctctggagc  gagacttgg  gagctgccc  900
ccgaccacc  caaggggcg  ctgctgcga  aagagctcg  tgcggcctc  tccgctgcc  960
tcagcaccc  cctggccgg  ccctttccc  ccacgcact  cagcaccct  tgcaagccc  1020
cgccgctca  agggaccct  gaggtacga  tggtgggct  cagagacct  ccagagacc  1080
tcccgtgga  ccctacccc  tcaatgggg  gacctggga  cccagacag  cgccccccc  1140
tcctgagcc  cccagcccg  ggcctttac  gccgaagcg  aagcctcag  ggccggagc  1200
gcctcaaag  agaagccga  aacaccagt  aagtcagca  tgtgcttaa  ctggataac  1260
cagtggtgg  gcagacgtc  tggaagcca  gtggcccca  tgcctggga  cagagcttc  1320
ctctggagc  ggaaagggc  cgggaactg  agttggctg  gttctggcg  gaccagcgg  1380
gcctgtgtg  cctcaaatt  ctgaagttg  aggatttct  ggacaatga  aggcatgag  1440
tgcagctgg  catggaacc  cagggctgc  tggtggctg  ggtcacctt  cgcaaccct  1500
tcattgaga  gattcctcg  ctccgacgg  agaagaaaa  tttctccaa  cagcaaggg  1560
aggcgttcc  gcgtgctag  cagatgaac  tcgatgtcg  cacgtgggt  cggctgctc  1620
ggaggctca  ccccaatgc  acgggcaca  gcaccttta  ccctggggc  tctccagga  1680
ccgaggccc  gaccacggg  gacatatcg  tggagaagc  gaacctcgg  actgactcg  1740
acagctcac  tcagaagag  tcgcgggat  ctccttcca  cccatcgag  ctgagctcc  1800
ccatccagg  atccactgc  cccgagctg  cttcggaga  ccaggagac  ccaggcccc  1860
ccctgtgca  ccctctgag  aagtcacct  tgaccctcg  agatttcaa  ttcctggcg  1920
tgctgggcc  gggtcattt  gggaaggtg  tcctctccg  attccggcc  agtggggag  1980
tgttcgcca  caaggctct  aagaaaggg  acattgtgg  ccgagacga  gtggagagc  2040
tgatgtgtg  gaagcggat  ttggcggca  tgaccagtg  gggacaccc  ttcctggtg  2100
acctcttcg  ctgtttcca  acaccggag  acgtgtgct  cgtgatgga  tactcggcc  2160
gtggggacc  gatgctgca  atccacagc  acgtgttct  tgagccccg  gccatcttt  2220
attccgcct  cgtggtgct  ggcctacag  ttcttcacg  acacaagat  gtctacagg  2280
acctgaagt  ggacaattt  ctcctggac  ccgagggct  cgtcaagat  gcagacttt  2340
gcctctgca  ggaggggat  ggctatggg  accggacca  cacattctg  gggaccccg  2400
agttcctgg  ccctgaggt  ctgacggac  cgtcgtaca  gcgagctgt  gactggtgg  2460
gactgggtg  gctgctcta  gagatgctg  ttggcgagt  cccattccc  ggggatgat  2520
aggaggagg  cttcgacag  atcgtcaac  acgaggttc  ctacccccg  ttcctgtcg  2580
ccgaagcca  cggcatcat  agaaggctg  ttcggagga  cccagagcg  aggctggga  2640
ctagcgaga  agatgcaga  gatgtgaag  aacagccct  cttcaggac  ctgggctgg  2700
aagccctgt  ggcccggcg  ctgccaccg  cctttgtgc  cacgctgtc  ggccgcacc  2760
acgtcagca  cttcgacga  gagttcacc  gggaggccc  cacactgag  ccgccccgc  2820
acgcgcggc  cctcacagc  gcggagcag  cagccttcc  ggacttcga  ttcgtggcc  2880
ggggctgct  gccccctcc  ctgcccctg  ccctgcccc  gcccgagag  tcttagttt  2940
taaaaaggc  tttgggatt  gccgg  2965



<210> 1900
<211> 942
<212> PRT
<213> Homo sapiens
<308> XP_031273
<400> 1900

Met Ala Ser Asp Ala Val Gln Ser Glu Pro Arg Ser Trp Ser Leu Leu 
  1               5                  10                  15
Glu Gln Leu Gly Leu Ala Gly Ala Asp Leu Ala Ala Pro Gly Val Gln 
             20                  25                  30
Gln Gln Leu Glu Leu Glu Arg Glu Arg Leu Arg Arg Glu Ile Arg Lys 
         35                  40                  45
Glu Leu Lys Leu Lys Glu Gly Ala Glu Asn Leu Arg Arg Ala Thr Thr 
     50                  55                  60
Asp Leu Gly Arg Ser Leu Gly Pro Val Glu Leu Leu Leu Arg Gly Ser 
 65                  70                  75                  80
Ser Arg Arg Leu Asp Leu Leu His Gln Gln Leu Gln Glu Leu His Ala 
                 85                  90                  95
His Val Val Leu Pro Asp Pro Ala Ala Thr His Asp Gly Pro Gln Ser 
             100                105                110
Pro Gly Ala Gly Gly Pro Thr Cys Ser Ala Thr Asn Leu Ser Arg Val 
         115                120                125
Ala Gly Leu Glu Lys Gln Leu Ala Ile Glu Leu Lys Val Lys Gln Gly 
     130                135                140
Ala Glu Asn Met Ile Gln Thr Tyr Ser Asn Gly Ser Thr Lys Asp Arg 
 145                150                155                160
Lys Leu Leu Leu Thr Ala Gln Gln Met Leu Gln Asp Ser Lys Thr Lys 
                 165                170                175
Ile Asp Ile Ile Arg Met Gln Leu Arg Arg Ala Leu Gln Ala Gly Gln 
             180                185                190
Leu Glu Asn Gln Ala Ala Pro Asp Asp Thr Gln Gly Ser Pro Asp Leu 
         195                200                205
Gly Ala Val Glu Leu Arg Ile Glu Glu Leu Arg His His Phe Arg Val 
     210                215                220
Glu His Ala Val Ala Glu Gly Ala Lys Asn Val Leu Arg Leu Leu Ser 
 225                230                235                240
Ala Ala Lys Ala Pro Asp Arg Lys Ala Val Ser Glu Ala Gln Glu Lys 
                 245                250                255
Leu Thr Glu Ser Asn Gln Lys Leu Gly Leu Leu Arg Glu Ala Leu Glu 
             260                265                270
Arg Arg Leu Gly Glu Leu Pro Ala Asp His Pro Lys Gly Arg Leu Leu 
         275                280                285
Arg Glu Glu Leu Ala Ala Ala Ser Ser Ala Ala Phe Ser Thr Arg Leu 
     290                295                300
Ala Gly Pro Phe Pro Ala Thr His Tyr Ser Thr Leu Cys Lys Pro Ala 
 305                310                315                320
Pro Leu Thr Gly Thr Leu Glu Val Arg Val Val Gly Cys Arg Asp Leu 
                 325                330                335
Pro Glu Thr Ile Pro Trp Asn Pro Thr Pro Ser Met Gly Gly Pro Gly 
             340                345                350
Thr Pro Asp Ser Arg Pro Pro Phe Leu Ser Arg Pro Ala Arg Gly Leu 
         355                360                365
Tyr Ser Arg Ser Gly Ser Leu Ser Gly Arg Ser Ser Leu Lys Ala Glu 
     370                375                380
Ala Glu Asn Thr Ser Glu Val Ser Thr Val Leu Lys Leu Asp Asn Thr 
 385                390                395                400
Val Val Gly Gln Thr Ser Trp Lys Pro Cys Gly Pro Asn Ala Trp Asp 
                 405                410                415
Gln Ser Phe Thr Leu Glu Leu Glu Arg Ala Arg Glu Leu Glu Leu Ala 
             420                425                430
Val Phe Trp Arg Asp Gln Arg Gly Leu Cys Ala Leu Lys Phe Leu Lys 
         435                440                445
Leu Glu Asp Phe Leu Asp Asn Glu Arg His Glu Val Gln Leu Asp Met 
     450                455                460
Glu Pro Gln Gly Cys Leu Val Ala Glu Val Thr Phe Arg Asn Pro Val 
 465                470                475                480
Ile Glu Arg Ile Pro Arg Leu Arg Arg Gln Lys Lys Ile Phe Ser Lys 
                 485                490                495
Gln Gln Gly Lys Ala Phe Gln Arg Ala Arg Gln Met Asn Ile Asp Val 
             500                505                510
Ala Thr Trp Val Arg Leu Leu Arg Arg Leu Ile Pro Asn Ala Thr Gly 
         515                520                525
Thr Gly Thr Phe Ser Pro Gly Ala Ser Pro Gly Ser Glu Ala Arg Thr 
     530                535                540
Thr Gly Asp Ile Ser Val Glu Lys Leu Asn Leu Gly Thr Asp Ser Asp 
 545                550                555                560
Ser Ser Pro Gln Lys Ser Ser Arg Asp Pro Pro Ser Ser Pro Ser Ser 
                 565                570                575
Leu Ser Ser Pro Ile Gln Glu Ser Thr Ala Pro Glu Leu Pro Ser Glu 
             580                585                590
Thr Gln Glu Thr Pro Gly Pro Ala Leu Cys Ser Pro Leu Arg Lys Ser 
         595                600                605
Pro Leu Thr Leu Glu Asp Phe Lys Phe Leu Ala Val Leu Gly Arg Gly 
     610                615                620
His Phe Gly Lys Val Leu Leu Ser Glu Phe Arg Pro Ser Gly Glu Leu 
 625                630                635                640
Phe Ala Ile Lys Ala Leu Lys Lys Gly Asp Ile Val Ala Arg Asp Glu 
                 645                650                655
Val Glu Ser Leu Met Cys Glu Lys Arg Ile Leu Ala Ala Val Thr Ser 
             660                665                670
Ala Gly His Pro Phe Leu Val Asn Leu Phe Gly Cys Phe Gln Thr Pro 
         675                680                685
Glu His Val Cys Phe Val Met Glu Tyr Ser Ala Gly Gly Asp Leu Met 
     690                695                700
Leu His Ile His Ser Asp Val Phe Ser Glu Pro Arg Ala Ile Phe Tyr 
 705                710                715                720
Ser Ala Cys Val Val Leu Gly Leu Gln Phe Leu His Glu His Lys Ile 
                 725                730                735
Val Tyr Arg Asp Leu Lys Leu Asp Asn Leu Leu Leu Asp Thr Glu Gly 
             740                745                750
Tyr Val Lys Ile Ala Asp Phe Gly Leu Cys Lys Glu Gly Met Gly Tyr 
         755                760                765
Gly Asp Arg Thr Ser Thr Phe Cys Gly Thr Pro Glu Phe Leu Ala Pro 
     770                775                780
Glu Val Leu Thr Asp Thr Ser Tyr Thr Arg Ala Val Asp Trp Trp Gly 
 785                790                795                800
Leu Gly Val Leu Leu Tyr Glu Met Leu Val Gly Glu Ser Pro Phe Pro 
                 805                810                815
Gly Asp Asp Glu Glu Glu Val Phe Asp Ser Ile Val Asn Asp Glu Val 
             820                825                830
Arg Tyr Pro Arg Phe Leu Ser Ala Glu Ala Ile Gly Ile Met Arg Arg 
         835                840                845
Leu Leu Arg Arg Asn Pro Glu Arg Arg Leu Gly Ser Ser Glu Arg Asp 
     850                855                860
Ala Glu Asp Val Lys Lys Gln Pro Phe Phe Arg Thr Leu Gly Trp Glu 
 865                870                875                880
Ala Leu Leu Ala Arg Arg Leu Pro Pro Pro Phe Val Pro Thr Leu Ser 
                 885                890                895
Gly Arg Thr Asp Val Ser Asn Phe Asp Glu Glu Phe Thr Gly Glu Ala 
             900                905                910
Pro Thr Leu Ser Pro Pro Arg Asp Ala Arg Pro Leu Thr Ala Ala Glu 
         915                920                925
Gln Ala Ala Phe Leu Asp Phe Asp Phe Val Ala Gly Gly Cys 
     930                935                940



<210> 1901
<211> 564
<212> DNA
<213> Rattus norvegicus
<308> D26500
<400> 1901

aggtgctac  tcactctca  tcagtctct  cacttgacc  tgagtgggg  tccagccgg  60
cctgcaggc  caggcaaga  agagaccac  aaggacctg  gccgagcac  gggcatcat  120
gtctatgtg  ttaactgtt  cgagcagat  gactacaag  cctgtggca  catctacaa  180
ggcctggct  agactggtg  ctggggctg  tttgatgaa  ttaaccgaa  ctctgtgga  240
gtcttgtca  tggtggctg  gcaggtgaa  agcatccag  acgcaatca  agacaagaa  300
cagaggttc  gcttccttg  ggaggagat  agccttgac  cttctgtgg  catcttcat  360
actatgaac  cgggctatg  tggccgcac  gaactgcca  aaaacctca  ggccctctt  420
aggccctgt  caatggtag  tccagactt  gagctgatc  gtgagatta  gctggtagc  480
gaaggattc  ttgaagccc  attgctggc  aggaagttc  ttacccttt  ccggctgtg  540
aaagaactt  tctccaaac  ggat  564



<210> 1902
<211> 188
<212> PRT
<213> Rattus norvegicus
<308> BAA05508
<400> 1902

Arg Cys Tyr Ile Thr Leu Thr Gln Ser Leu His Leu Thr Met Ser Gly 
  1               5                  10                  15
Ala Pro Ala Gly Pro Ala Gly Thr Gly Lys Thr Glu Thr Thr Lys Asp 
             20                  25                  30
Leu Gly Arg Ala Leu Gly Ile Met Val Tyr Val Phe Asn Cys Ser Glu 
         35                  40                  45
Gln Met Asp Tyr Lys Ser Cys Gly Asn Ile Tyr Lys Gly Leu Ala Gln 
     50                  55                  60
Thr Gly Ala Trp Gly Cys Phe Asp Glu Phe Asn Arg Ile Ser Val Glu 
 65                  70                  75                  80
Val Leu Ser Val Val Ala Val Gln Val Lys Ser Ile Gln Asp Ala Ile 
                 85                  90                  95
Arg Asp Lys Lys Gln Arg Phe Ser Phe Leu Gly Glu Glu Ile Ser Leu 
             100                105                110
Asp Pro Ser Val Gly Ile Phe Ile Thr Met Asn Pro Gly Tyr Ala Gly 
         115                120                125
Arg Thr Glu Leu Pro Glu Asn Leu Lys Ala Leu Phe Arg Pro Cys Ala 
     130                135                140
Met Val Val Pro Asp Phe Glu Leu Ile Cys Glu Ile Met Leu Val Ala 
 145                150                155                160
Glu Gly Phe Ile Glu Ala Arg Leu Leu Ala Arg Lys Phe Ile Thr Leu 
                 165                170                175
Tyr Arg Leu Cys Lys Glu Leu Leu Ser Lys Gln Asp 
             180                185



<210> 1903
<211> 13748
<212> DNA
<213> Homo sapiens
<308> NM_001372
<400> 1903

agcagagga  tgagtcctg  ccgcgtccc  gtcgctagg  aaaccgatg  agctggagg  60
cgcgcgcga  gcggctcgc  gaggagcgg  ccgcgctcg  ggcggagaa  gcggatggg  120
aacccggcg  cgaccgacg  ctgcgactc  tggggacct  cgtggccat  agcctgcgg  180
cggctgcgg  cgcctggga  cgttgcgcg  ggagtgctg  ggcggagca  ctgctccag  240
ccttcctgg  ccgcgatgc  gccgagggg  cgcggccgc  gctggtggt  cggcccggg  300
ccaggggcc  ggcaatacg  cccgggctg  aggtgggac  tgagtcggg  ctggctggc  360
ctaaggcgc  ttttttcct  cgcaccggg  ccgagcctc  agggcccga  agcttccgc  420
gcgcagtgg  ctgcgggga  ctgcccgcg  cacctctgg  gcacctagc  gcgctgttc  480
cggaggttg  tctacccgt  ctggccaat  agaagaatc  cctaaactg  ccccacatg  540
tatgtgagg  tgtcaggcg  cacgcccac  gcctccaat  tgacctctc  gttatactt  600
agcaagtga  gggaaaaac  ttgctgcct  ttccagcag  ctcagaaaa  atggagttt  660
cggattcca  aagtgagac  gtcttggat  ctatagata  gtcagtcat  tatgccatt  720
agtctgcag  gatcaaatg  agctaccaa  tccaggtgg  actcaagag  gagtcttcc  780
agccactct  acaagggga  aatcccacc  ctaaggtgg  gttggagtt  tggaagagc  840
ggtatgaag  tctgaaata  atctataat  aactgagaa  aataacggt  aggggcatg  900
ccaagctcc  ggacaagct  cagagtagc  actttccag  tttcaaagc  atgtacaga  960
atgttgttg  agctctagc  gaggcacag  acatccatg  gcacctgat  ccgctccag  1020
gccacctgg  agctctgga  aatgcagaa  ttccggagg  gaagcccca  ctgcggccc  1080
tgctccacg  ggtctgtct  atttgggcc  catgcaagt  ctaccgctc  ccgggaagg  1140
tgactgtgc  gctccagga  atttgcaac  ttctcatcc  gcaggcctc  aattatctc  1200
gcccagaag  cctgctgag  agtgaggta  aagaaagtc  gagaaaact  caagtggtc  1260
cagacactt  gagcttctt  aagcaagag  ttcaggaca  aagggagaa  ctccacact  1320
acttcaaag  gaaccagga  gtcaaggaa  gggatttcc  gtcttcttt  gtctttgtg  1380
gattggatg  cttcctggg  cgactgcac  tggtggagg  tcttctgaa  acggccctg  1440
atttccaca  actgggaaa  gtggagttc  gcggcgtca  agggaatgc  ctgagtcag  1500
aggtccagc  aatgcatga  gaatttcaa  agatgtaca  gcttctctc  ggatcctcc  1560
ccgactgcc  gtacctcca  agcacggac  ttgaaaatg  cgtctctga  tttaaccag  1620
aagtagaag  tcttgaccg  agattgggg  ctatcttta  tcaagcttt  gatgatgca  1680
ctggcttgg  gcatgcctt  aagctgcta  acatagcag  aaacctcct  gaaagaccg  1740
tggtagcga  ggatacatc  gataaatac  tggtcctca  ccaaatgtt  aacaaagat  1800
tggatgcag  gaggatgat  tacagtcag  acgtccagg  ggaagcaga  cttgggttc  1860
ccccggtgc  caagaacat  cccaccgtg  ctggcggcc  ccgctgggc  caggagctg  1920
ggcagcgca  ccagggtcc  ttcagcaac  ttggacgca  cacacaccc  tgcatggaa  1980
ctgcagaag  aaagcgaat  caacaaaaa  atgaagata  gctgtcatt  ctagaaaag  2040
atgagacaa  actttatga  gattggtgc  ggacagtat  agagaagtc  cagtacaat  2100
tttcccaac  acttctaaa  cgtgaccca  agacgaagg  gatcactat  aactttaac  2160
cacagctga  ttcagtgct  aaagaaatg  gctatcttg  acccagaga  atgaaacac  2220
tgcctgaga  agcagcagc  atgttctcc  ccagggatt  ctatcggca  cttgtggct  2280
atttagagt  gatggcaaa  tggtacaac  aggttatga  aactctgct  gaggtggaa  2340
ttccattag  ggaggaaga  ctgcaaaat  ttgatctcc  cctcagagc  gcagaggag  2400
ctttgaact  gaaaacaga  ggcatttgc  attatgtca  tgaaatcac  agtagtatt  2460
atgatcttg  acaaagaat  cagaaaact  aagacaatg  ggaagagat  caaaacatc  2520
tgaaaacat  ggtgactcc  atatttaag  caaaagatg  aaaaaggga  tcccttctt  2580
ctctggatg  tcggcatga  cgaatggaa  aatattaca  tctcatcaa  gaatctggc  2640
ttaagatcc  cgcccttgt  caggaaaac  tgggtctat  ttcagcaga  ccaacctcc  2700
atatctgga  gacttatgt  aactctatt  acaatttgt  gctgaatgg  ttctttctt  2760
ccattgagt  ctccctcaa  tatcttctg  aaaatactg  gtgtaaggc  ggacttacc  2820
caatatttg  agcacaact  agtctagcc  tcccagagc  agttttcta  ccgtctctg  2880
agtctggag  gaagggggg  ttctgtgac  ttgttgagg  tctcatcac  agcattttt  2940
ggataccat  tctggtgcc  cggctttcc  cacaaaatg  ctctcctca  tatcaggtc  3000
acctggacg  tataccaga  ttggcaaac  tgcggcgca  actcatgga  agagtccag  3060
gaatgatgg  cctctgctg  ggctatcag  gcaccttca  ccagtattc  tacctctat  3120
tggaggacc  gaaggaggt  ctgggtcag  ttctgctgt  cgggcacat  ctcactccg  3180
aagaaattg  agaccatgt  gaagatggc  tcccagaga  ccctcccct  ctttctcag  3240
ttaaagtgc  aatcgactc  tatgaaacg  tctatgaag  ggtgtgcag  ctggaaccc  3300
tcaaggtgt  tgacggctg  atgaaaatt  atattcgac  ctttaaggc  tctctgctg  3360
atattatta  gaggtggag  ctcctgttc  aacagcatc  tgtggacca  gtcactcac  3420
gcttggcca  cctggacgc  tttataaag  agagtgaga  cggcttact  aagaaagtt  3480
aaaaaggag  tttccaagg  ttggttgag  tcatgggac  ccttatggc  gttaaagaa  3540
ggcagagta  cactgatga  atgtttgag  ccttaaagc  gactattga  ttgctgaag  3600
cctatgaac  agaattgcc  gaaacagtg  ttaagcagc  ggaggagct  cctgagaaa  3660
ggaacaaca  aaaaaaggt  gccattact  tgaagcagc  ggtggcccc  ctgcaggca  3720
atgaagtga  actcctccg  cagaggtgc  cagccttcg  tgcagaaca  cagcaattc  3780
gggagcaat  ccacaaaga  gccccgttc  ggtttgata  catccaccc  catcaaatg  3840
tggatgcca  gcacatcga  atccagcag  tggaatcca  tatggcctc  atttctgag  3900
ctgccagct  atttgaagt  aatgtccct  actataagc  gctgaggca  tgcaggaag  3960
aggtctgcc  gctgaagga  ctctgggac  ccattggaa  ggtgacctc  agcatccat  4020
cctgggaga  cacaccctg  aggaatatc  acgtggaag  catggagtt  gagtgcaaa  4080
agtttgccc  gcatatccg  aacctggac  aggaggtca  ggcctggga  gcattcaca  4140
gcctggaaa  cactgtgtg  aacacgctg  gctccctga  ggcagtagc  gagctgcag  4200
atccagcca  ccgggagcg  cactggagg  agctgatgc  ggccaccgg  gtgagcttc  4260
ctatggacc  ggacaccac  ctagcgcac  tgctgcagc  ccagctgca  cactatgag  4320
atgaggtcc  gggcattgt  gacaaagct  caaaagaga  gggtatgga  aaaacctta  4380
aggagctgc  gactacctg  gctggcatg  aattccagt  tgagcccca  ccacggacc  4440
atgtccccc  cctgtgctc  gatgaggac  tcatagagg  tctggagga  aatcaagtt  4500
aacttcaga  cctggtgat  tccaagtat  ttgctttct  cttggagga  gtgtcgggc  4560
ggcagaaga  gctgtccac  gtggacgct  tcatctcta  ctggtttga  gtgcagcga  4620
catggactc  cctggaaag  atattcact  gatctgaag  tattcgggc  cagctaccc  4680
aggattcta  aaggtttga  ggcatcgac  ttgacttta  agagctagc  tatgatgcc  4740
agaaaattc  aaatgtagt  caaaccacc  acaagccag  cctgtatga  aagctggag  4800
atattcagg  cagattgtg  ctgtgtgag  aggccctgg  agagtacct  gacaccaag  4860
ggcttgcct  cccgcggtt  tactttctc  cctcctccg  tctgttaga  atcctttcc  4920
acggcacag  tccacaaca  gttcaacgt  acctttcca  actctttga  aacatggcc  4980
agatgcgat  ccagctaga  gccagtggg  aaccaacca  gacaagcct  ggcatgtac  5040
gcaaagaag  ggagtatgt  gctttcagt  agccctgtg  ctgcagcgg  caggtagaa  5100
tatggctga  ccatgtcct  ggtcacatg  aggccactg  gaggcatga  atgacagaa  5160
gtgtaactg  ctatgaaga  aagccgagg  agcagtggc  ttttgacca  ccagctcag  5220
tggccctga  ctgtactca  atctggtgg  caacagaag  gggcatggc  tttgccagg  5280
tggaggaag  ctatgagag  gccatgaag  actattata  gaagcaagt  gcccagctc  5340
aaaccctta  caccatgct  attggccag  tctccaagg  agaccggca  aagattatg  5400
ctatatgca  catcgatgt  catgcccgg  atgtggtag  caagatgat  gctcagaag  5460
tagacaatg  ccaggcttt  ctctggctg  ctcagctgc  ccatcgttg  gatgacgag  5520
tcaaacact  ctttgccaa  atctgtgat  cccagtttt  gtattccta  gagtacctg  5580
gaaacacac  tcgcttggt  atcacacct  tgactgaca  gtgctacat  accctcacc  5640
agtccctgc  cctgaccat  agtggggct  ccgcaggac  tgcaggcac  ggcaagacc  5700
agaccacca  ggacctggg  cgcgcactg  gcatcctgg  ctatgtgtt  aactgctcg  5760
agcagatgg  ttacaagtc  tgtggcaac  tctacaaag  ccttgctca  actggtgcc  5820
ggggctgct  tgatgagtt  aatcgaatc  ccgtggagg  cttgtcagt  gtggcagtg  5880
aggtaaaaa  cattcaaga  gcgattaga  ataagaagc  gtggttcag  ttccttggg  5940
aggagatca  cctgaatcc  tctgtcggt  tcttcatca  catgaaccc  ggctatgct  6000
gccgcacag  gctgccaga  aatctcaag  ctctcttca  gccttgtgc  atggtggtt  6060
cagactttg  attgatctg  gaaatcatg  tggtggcag  aggattcat  gaagcccag  6120
cattagcca  aaagttcat  actctttac  agttgtgca  agagcttct  tccaaacag  6180
atcactacg  ctggggcct  cgggccatc  agtccgtgc  ggtggtggc  ggatccctg  6240
agagaggag  ccctgaccg  cctgaggac  aggtcctga  gcgctcctt  cgggatttc  6300
acatcccca  gattgtgac  gatgacatg  ccatcttca  gggcctgat  ggggacctc  6360
ttcccgccc  ggatgtccc  cggaggaga  accccaact  cgaagcttt  gttaggaag  6420
cgatagtgg  tctgaagct  caggctgag  acaactttg  gctcaaggt  gtccagctg  6480
aggagctcc  ggctgtgcg  cactctgta  ttgtggtgg  tggcgctgg  accggcaag  6540
cacaggtgc  gaggtcctt  cacaagacc  atcagatca  gaaacggcg  cccgtctgg  6600
ctgacctca  tcccaaagc  gtcacaaat  atgagctct  tggcatcat  aatccagcc  6660
caggagaat  gaaggatgg  ttgttctct  ccatcatgc  ggagcttgc  aacatcacc  6720
atgatgggc  caagtggat  ttactggat  gcgacatag  tccaatgtg  attgaatcc  6780
tgaatactg  catggatga  aacaaggtg  tgacattgg  cagcaatga  aggattcct  6840
tgaacccca  catgaagct  ctctttgag  tcagccacc  gcgcacagc  actccagca  6900
ctgtctcta  agcagggat  ttgtacatc  acccggcag  cttgggatg  aaccctcca  6960
tgagcagct  gattgagaa  agggaaatc  agacagaga  agccaactt  accattttg  7020
tcgacaagt  tcttccaac  tgcctagac  cactcagaa  caggtttaa  aagatcatt  7080
ccatcccag  gcagagcat  gttcagatg  tgtgtcacc  tctggaatg  ctcctgacc  7140
cggaggaca  ccctgcaga  tgccctaag  aaatttatg  gcattattt  gtgtttgct  7200
ccatctggg  tttcggcgg  gcaatggtc  aagatcagc  tgtggacta  cgggcagag  7260
tcagcaaat  gtggctgac  gagttcaaa  cagtcaagt  tccttccca  ggaaccatc  7320
ttgactatt  catcgaccc  gagaccaag  aattcgagc  ttggtccaa  ctcgtcccc  7380
agttcgaat  tgaccccga  atgcccttg  aggcgtgtt  ggtgcacac  agtgagacc  7440
tccgtgtgt  ctacttcat  gagcggttg  tggcgcggc  gcggcctgt  atgctggtg  7500
gcacggctg  cactggcaa  tcggtgctg  tgggagcta  gctggccag  cttgacccc  7560
aggcatacc  ggtgaaaaa  gtgccattc  actactaca  cacgtcagc  atgctgcag  7620
ctgtcctgg  gaagcctct  gaaaagaag  ctggcagaa  ctatggccc  ccagggaac  7680
agaaactca  ctatttcat  gatgacatg  acatgcctg  ggtggatgc  tacgggacg  7740
tgcagcccc  caccatcat  cggcagcat  tggactatg  ccactggta  gatcggagc  7800
agctgtccc  aaaggagat  acaaatgta  agtatgttt  ctgtatgaa  cccacggca  7860
gcagcttca  catcaaccc  cggcttcag  gtcacttca  cgtgtttgt  ctctccttc  7920
cgggggcag  tgccctgtc  tctatctac  gcatcatcc  cactcagca  ctgaagctc  7980
gaaacttcc  ggcgtccct  cagaaatcc  tccccccac  gatcgatct  gccctcgcc  8040
tccaccaga  aattgctac  accttccta  ccacaggaa  caaattcca  tacatcttc  8100
acctcagag  ttttgccaa  attttccag  gcattctct  ctcctcagt  gaatgtgtg  8160
aatccacat  ggatcttat  aggctctat  tgcatgaat  aaatcgagt  tatcgggat  8220
agatggtag  agaaaagga  tttgatctt  ttgataaaa  ccagacaga  gtgctcaag  8280
aaacttttg  tgatattga  gaccctgtg  agcagaccc  aagcccgaa  ctgtattgt  8340
actttgcaa  tggtattgg  gagcccaaa  acatgcctg  acagtcttg  gaacttttg  8400
cccagactc  ggtggaggc  ttggagaac  acaatgaag  caacacagt  atggaccta  8460
ttctctttg  ggatgccat  cgccatgtc  gccatatca  tcgcatctt  gagtccccg  8520
ggggaaatg  tctgctggt  ggtgtaggt  ggagcggca  gcagagcct  acaaggctg  8580
cagctttca  cagctccat  gatgtcttc  agatcacac  gcgcaaagg  taccagatc  8640
aggacttca  gatggacct  gccagcctg  gtctgaaag  tggagtgaa  aatctcaac  8700
cagtgtttc  catgactga  gcccaagtg  ctgatgaga  gttccttgt  ctcatcaat  8760
atcttttgg  atctgggga  atcccagat  tctactctg  tgatgaagt  gaaaacatc  8820
taagcaatg  gaggaatga  gtcaagagc  agggtctgg  tgacaacag  gagaactgt  8880
ggaagttct  tatagatcg  atccggcga  agctgaagg  gactctctg  ttctcccct  8940
tgggaaaca  gctaagagt  cgcagcagg  agttcccag  cattgtgaa  tgcacagcc  9000
tccactggt  ccacgagtg  cctcagcaa  cattggagt  tgtcagcct  cgcttcttg  9060
agaacacag  gggcattga  cccacagta  agcagtcga  tagcaaatt  atggccttt  9120
tccacacaa  tgtcaacca  acatcccag  cttatctga  caatgaaca  cgctacaac  9180
atacaactc  caagtcctt  ctggagttc  tcagactct  ccagagctt  ttgcacagg  9240
acagaaaag  gctcaagtg  aagacagag  ggttggaga  cgggctgct  aagctgcat  9300
gcacctctg  ccaggtgga  gatctgaaa  caaagctgg  tgcccagga  gtagagctg  9360
agcagaaaa  tgaagatgc  gacaaactg  ttcaggtcg  gggtgtgga  actgacaaa  9420
tgagcagag  gaaagccat  gcagatgaa  aggagcaga  ggtggccgt  atcatgcta  9480
aggtgaaac  gaagcagaa  gactgtgag  aggacctgg  aaaggctga  ccagcactc  9540
cagcagcgc  ggcagctct  aacaccctg  acaagacca  cctgacaga  ctgaagtca  9600
ttggctctc  gcctctggc  gtcagcaat  tcagcgctg  ggtgatggt  ctgatggct  9660
ccaggggta  ggtgcccaa  gaccggagc  ggaaggctg  taaggtcac  atggccaaa  9720
tggatggct  cctggactc  ctaataaac  tcaacaaag  gaacattca  gagaactgc  9780
tcaaagcca  caggccgta  ctgcaagac  cggagttca  tcctgagtt  gtggccacc  9840
aatcctatg  ggctgcagg  ctctgctcc  gggtcatca  tattgtgag  ttttatgag  9900
tgttctgtg  tgtggaacc  aagcgccag  cactgaaca  agccaccgc  gacctcaca  9960
ctgcccagg  gaagctggc  gccatcaaa  ccaagatcg  tcaccttaa  gaaaacctg  10020
caaagctca  agccaggtt  gagaaagca  cagcagaca  actcaaatg  cagcaagaa  10080
ccgaagtga  cgcagtcac  atctccctt  ccaaccgcc  ggttggagg  ctcgcttct  10140
aaaacgtga  gtgggcaga  gccgtgcag  acttcaaac  gcaggaaag  acgttatgt  10200
gagacattt  acttataac  gctttcatt  cctaccttg  cttcttcac  aagaaatac  10260
ggcagagcc  cctggacag  acttggagg  cctacctga  ccagctgaa  actcccatt  10320
cagtcaccc  agccctgga  cccctgagg  tgctgatgg  tgatgctga  gtggctgcc  10380
ggcagaacg  gggcctccc  gccgaccgc  tgtccgtgg  gaatgccac  attctcatc  10440
actgtgagc  ctggccact  atggttgac  ctcagctac  aggcatcaa  tggatcaag  10500
ataaatatg  tgaagatct  cgggtcacg  agattggtc  gaaaggcta  cttcaaatc  10560
tagagcagg  cctggaagc  ggagctgtg  tgctgattg  aaatctaga  gagtccatt  10620
atcctgttc  gggacccct  cttgggaga  aagtcatta  aaaaggacg  ttcattaaa  10680
ttggagaca  agaatgtga  tacaatccc  agttccggc  catcctcca  accaagctg  10740
ctaatcctc  ctaccagcc  gagctgcag  ctcaggcca  cctgatcaa  ttcaccgtg  10800
ccagggatg  cctggagga  cagttgctg  ccgctgtgg  cagcatgga  aggccagac  10860
tggagcagc  gaagtccga  ctcacaaag  agcagaatg  attcaaaat  accctgaaa  10920
cgctggaag  cagtcttct  tctcgcctc  cctccgcct  tgggaactt  ctgggagaa  10980
cagtgctgg  ggaaaacct  gagatcacc  agcagactg  tgccgaagt  gagaaaaag  11040
tccaggagg  caaggtgac  gaagtgaaa  tcaacgagg  ccgagagca  taccggcca  11100
cagctgcca  ggcctcact  ctctacttc  tcatgaacg  cctcagcaa  atccatcca  11160
tgtaccagt  ttctctcaa  gccttcagt  tcgtcttcc  gaaggctgt  gagagggct  11220
ctcctgacg  aagcctcag  gagcgggtg  ccaacctaa  agacagcat  accttctct  11280
tgtaccagt  caccatccg  gggctcttt  agtgtgata  gctgaccta  cttgcccag  11340
tcacctttc  gattctcct  atgaaccga  aagtcaatg  agtggagtt  gatttcctg  11400
ttcgatctc  agtgcagac  ggcaccgcc  gccccgtgg  gttcctctc  catcaggcg  11460
ggggagctg  caaggtact  tcatcaatg  aagaattct  taatctgga  cgggacata  11520
agggatctg  taagagctg  aaaaagttt  tggagtccg  atgtcctga  aaagagaag  11580
tcccacagg  gtggaagaa  aagacagcc  tgcagcgcc  ctgcatgct  agagccatg  11640
ggcccgacc  gatgaccta  gctttgcga  attttgttg  agagaagtt  ggaagcaaa  11700
acgtggtgg  aagagccct  gattttgca  cctcatttg  agaatcggg  ccagccact  11760
ctatgtttt  catcctgtc  ccaggggtg  acccactga  ggatgtaga  agtcaagga  11820
gaaaacttg  atacacctt  aacaatcag  actttcaca  cgtgtcttt  gggcaagga  11880
aggaagtgg  ggctgaggc  gcgctggac  tcgctgcca  gaaaggtca  tgggttatt  11940
tgcagaaca  tcacctggt  gccaagtgg  tcagcaccc  ggagaagaa  ctggaggag  12000
acagtgaga  cagccaccc  gagttcagg  tcttcatga  tgcagagcc  gcaccctcc  12060
ctgagggcc  catcatccc  cagggcatc  tggagaact  cattaagat  accaatgag  12120
cccccacgg  catgcatgc  aacctgcac  aggccctgg  caacttcac  caggacact  12180
tggagatgt  ttctcggga  acggagttt  agagcatcc  ctttgctct  tgttacttc  12240
atgcggtgg  ggcagaaag  cgaaaattt  ggccccagg  atggaatcg  tcatacccc  12300
ttaacactg  agacctcac  atctctgtg  atgtcctct  caacttcct  gaggccaac  12360
caaaggtcc  ctatgatga  ttgcgctac  tgtttggag  gatcatgta  ggaggccat  12420
tcacagatg  ctgggacag  agactctgc  gaacctacc  gggggaatt  attcgacca  12480
aaatgttag  aggagaact  tctttggcc  cagggttcc  actcccagg  aacatggac  12540
acaatggtt  tcatcagta  atcgatgct  agctgcccc  agaatcccc  tacctctat  12600
gcctccacc  gaacgcaga  attggcttc  tgacccaaa  ctcagaaaa  ctcttccgc  12660
ctgtgctgg  gctgcagcc  cgggacagc  aggccagag  cggagcggg  gccacaaga  12720
aagaaaagg  caaggcact  ctggaagaa  tattggagc  ggtgacaga  gagtttaac  12780
tcccagaac  gatggccaa  gtggaggag  gcacccctt  cattgtagt  gccttccag  12840
agtgtggcc  gatgaatat  ctcaccaga  agattcagc  ctcactgag  gagctggag  12900
tcggcttaa  gggggagct  actatgacc  gccacatgg  gaacttaca  aatgccctg  12960
acttcgata  ggtgccaga  tcctgggct  gacgagcct  cccttccac  gcaggcctg  13020
cagcctggt  tccagacct  ctcaacaga  tcaaggagc  agaggcttg  acgggtgac  13080
ttacaatgc  ctccactgt  tggctgaca  gcttcttca  cccccagtc  ttcctgact  13140
ccatcatgc  gtccacggc  cgcaagaat  agtggccac  ggaccagat  gccctgcaa  13200
gtgacatga  gaagaagaa  agagaagag  ttaggagtc  tcctcggga  ggggcctac  13260
tccatggcc  cttcatgga  ggtgcctgc  gggacacac  ggctgggat  attacagag  13320
caaagctga  ggatctgac  ccccctatg  ctgtgatgt  catcaaggc  attcctgca  13380
ataagcagg  ctgccgcag  gtctattcc  gtcctgtgt  caagactag  cagcgggga  13440
ccacctacg  gtggacttt  aacctgaag  ctaaggaaa  cccatccaa  tgggttctg  13500
ctggagtag  cttgcttct  cagatttag  atcctgcag  gccaccgag  aaataaaaa  13560
gctgggctt  gaggctgcc  agagggaca  gtgggtgaa  ggtcaccac  gacacttag  13620
acggtaaga  accatgagc  ctcacaatt  tgtagaatt  ctctaggga  cttggagag  13680
tgtgcctaa  gtgaggctg  gctgaagga  tgtgggccc  ggtttctta  taaaatgat  13740
tactcttc  13748



<210> 1904
<211> 4486
<212> PRT
<213> Homo sapiens
<308> Q9NYC9
<400> 1904

Met Arg Leu Ala Glu Glu Arg Ala Ala Leu Ala Ala Glu Asn Ala Asp 
  1               5                  10                  15
Gly Glu Pro Gly Ala Asp Arg Arg Leu Arg Leu Leu Gly Thr Tyr Val 
             20                  25                  30
Ala Met Ser Leu Arg Pro Ala Ala Gly Ala Trp Glu Arg Cys Ala Gly 
         35                  40                  45
Ser Ala Glu Ala Glu Gln Leu Leu Gln Ala Phe Leu Gly Arg Asp Ala 
     50                  55                  60
Ala Glu Gly Pro Arg Pro Leu Leu Val Val Arg Pro Gly Pro Arg Gly 
 65                  70                  75                  80
Leu Ala Ile Arg Pro Gly Leu Glu Val Gly Pro Glu Ser Gly Leu Ala 
                 85                  90                  95
Gly Ala Lys Ala Leu Phe Phe Leu Arg Thr Gly Pro Glu Pro Pro Gly 
             100                105                110
Pro Asp Ser Phe Arg Gly Ala Val Val Cys Gly Asp Leu Pro Ala Ala 
         115                120                125
Pro Leu Glu His Leu Ala Ala Leu Phe Ser Glu Val Val Leu Pro Val 
     130                135                140
Leu Ala Asn Glu Lys Asn Arg Leu Asn Trp Pro His Met Ile Cys Glu 
 145                150                155                160
Asp Val Arg Arg His Ala His Ser Leu Gln Cys Asp Leu Ser Val Ile 
                 165                170                175
Leu Glu Gln Val Lys Gly Lys Thr Leu Leu Pro Leu Pro Ala Gly Ser 
             180                185                190
Glu Lys Met Glu Phe Ala Asp Ser Lys Ser Glu Thr Val Leu Asp Ser 
         195                200                205
Ile Asp Lys Ser Val Ile Tyr Ala Ile Glu Ser Ala Val Ile Lys Trp 
     210                215                220
Ser Tyr Gln Val Gln Val Val Leu Lys Arg Glu Ser Ser Gln Pro Leu 
 225                230                235                240
Leu Gln Gly Glu Asn Pro Thr Pro Lys Val Glu Leu Glu Phe Trp Lys 
                 245                250                255
Ser Arg Tyr Glu Asp Leu Lys Tyr Ile Tyr Asn Gln Leu Arg Thr Ile 
             260                265                270
Thr Val Arg Gly Met Ala Lys Leu Leu Asp Lys Leu Gln Ser Ser Tyr 
         275                280                285
Phe Pro Ala Phe Lys Ala Met Tyr Arg Asp Val Val Ala Ala Leu Ala 
     290                295                300
Glu Ala Gln Asp Ile His Val His Leu Ile Pro Leu Gln Arg His Leu 
 305                310                315                320
Glu Ala Leu Glu Asn Ala Glu Phe Pro Glu Val Lys Pro Gln Leu Arg 
                 325                330                335
Pro Leu Leu His Val Val Cys Leu Ile Trp Ala Thr Cys Lys Ser Tyr 
             340                345                350
Arg Ser Pro Gly Arg Leu Thr Val Leu Leu Gln Glu Ile Cys Asn Leu 
         355                360                365
Leu Ile Gln Gln Ala Ser Asn Tyr Leu Ser Pro Glu Asp Leu Leu Arg 
     370                375                380
Ser Glu Val Glu Glu Ser Gln Arg Lys Leu Gln Val Val Ser Asp Thr 
 385                390                395                400
Leu Ser Phe Phe Lys Gln Glu Phe Gln Asp Arg Arg Glu Asn Leu His 
                 405                410                415
Thr Tyr Phe Lys Glu Asn Gln Glu Val Lys Glu Trp Asp Phe Gln Ser 
             420                425                430
Ser Leu Val Phe Val Arg Leu Asp Gly Phe Leu Gly Arg Leu His Val 
         435                440                445
Val Glu Gly Leu Leu Lys Thr Ala Leu Asp Phe His Lys Leu Gly Lys 
     450                455                460
Val Glu Phe Ser Gly Val Arg Gly Asn Ala Leu Ser Gln Gln Val Gln 
 465                470                475                480
Gln Met His Glu Glu Phe Gln Glu Met Tyr Arg Leu Leu Ser Gly Ser 
                 485                490                495
Ser Ser Asp Cys Leu Tyr Leu Gln Ser Thr Asp Phe Glu Asn Asp Val 
             500                505                510
Ser Glu Phe Asn Gln Lys Val Glu Asp Leu Asp Arg Arg Leu Gly Thr 
         515                520                525
Ile Phe Ile Gln Ala Phe Asp Asp Ala Pro Gly Leu Glu His Ala Phe 
     530                535                540
Lys Leu Leu Asp Ile Ala Gly Asn Leu Leu Glu Arg Pro Leu Val Ala 
 545                550                555                560
Arg Asp Thr Ser Asp Lys Tyr Leu Val Leu Ile Gln Met Phe Asn Lys 
                 565                570                575
Asp Leu Asp Ala Val Arg Met Ile Tyr Ser Gln His Val Gln Glu Glu 
             580                585                590
Ala Glu Leu Gly Phe Ser Pro Val His Lys Asn Met Pro Thr Val Ala 
         595                600                605
Gly Gly Leu Arg Trp Ala Gln Glu Leu Arg Gln Arg Ile Gln Gly Pro 
     610                615                620
Phe Ser Asn Phe Gly Arg Ile Thr His Pro Cys Met Glu Ser Ala Glu 
 625                630                635                640
Gly Lys Arg Met Gln Gln Lys Tyr Glu Asp Met Leu Ser Leu Leu Glu 
                 645                650                655
Lys Tyr Glu Thr Arg Leu Tyr Glu Asp Trp Cys Arg Thr Val Ser Glu 
             660                665                670
Lys Ser Gln Tyr Asn Leu Ser Gln Pro Leu Leu Lys Arg Asp Pro Glu 
         675                680                685
Thr Lys Glu Ile Thr Ile Asn Phe Asn Pro Gln Leu Ile Ser Val Leu 
     690                695                700
Lys Glu Met Ser Tyr Leu Glu Pro Arg Glu Met Lys His Met Pro Glu 
 705                710                715                720
Thr Ala Ala Ala Met Phe Ser Ser Arg Asp Phe Tyr Arg Gln Leu Val 
                 725                730                735
Ala Asn Leu Glu Leu Met Ala Asn Trp Tyr Asn Lys Val Met Lys Thr 
             740                745                750
Leu Leu Glu Val Glu Phe Pro Leu Val Glu Glu Glu Leu Gln Asn Ile 
         755                760                765
Asp Leu Arg Leu Arg Ala Ala Glu Glu Thr Leu Asn Trp Lys Thr Glu 
     770                775                780
Gly Ile Cys Asp Tyr Val Thr Glu Ile Thr Ser Ser Ile His Asp Leu 
 785                790                795                800
Glu Gln Arg Ile Gln Lys Thr Lys Asp Asn Val Glu Glu Ile Gln Asn 
                 805                810                815
Ile Met Lys Thr Trp Val Thr Pro Ile Phe Lys Thr Lys Asp Gly Lys 
             820                825                830
Arg Glu Ser Leu Leu Ser Leu Asp Asp Arg His Asp Arg Met Glu Lys 
         835                840                845
Tyr Tyr Asn Leu Ile Lys Glu Ser Gly Leu Lys Ile His Ala Leu Val 
     850                855                860
Gln Glu Asn Leu Gly Leu Phe Ser Ala Asp Pro Thr Ser Asn Ile Trp 
 865                870                875                880
Lys Thr Tyr Val Asn Ser Ile Asp Asn Leu Leu Leu Asn Gly Phe Phe 
                 885                890                895
Leu Ala Ile Glu Cys Ser Leu Lys Tyr Leu Leu Glu Asn Thr Glu Cys 
             900                905                910
Lys Ala Gly Leu Thr Pro Ile Phe Glu Ala Gln Leu Ser Leu Ala Ile 
         915                920                925
Pro Glu Leu Val Phe Tyr Pro Ser Leu Glu Ser Gly Val Lys Gly Gly 
     930                935                940
Phe Cys Asp Ile Val Glu Gly Leu Ile Thr Ser Ile Phe Arg Ile Pro 
 945                950                955                960
Ser Leu Val Pro Arg Leu Ser Pro Gln Asn Gly Ser Pro His Tyr Gln 
                 965                970                975
Val Asp Leu Asp Gly Ile Pro Asp Leu Ala Asn Met Arg Arg Thr Leu 
             980                985                990
Met Glu Arg Val Gln Arg Met Met Gly Leu Cys Cys Gly Tyr Gln Ser 
         995                1000                1005
Thr Phe Ser Gln Tyr Ser Tyr Leu Tyr Val Glu Asp Arg Lys Glu Val 
     1010                1015                1020
Leu Gly Gln Phe Leu Leu Tyr Gly His Ile Leu Thr Pro Glu Glu Ile 
 1025                1030                1035                1040
Glu Asp His Val Glu Asp Gly Ile Pro Glu Asn Pro Pro Leu Leu Ser 
                 1045                1050                1055
Gln Phe Lys Val Gln Ile Asp Ser Tyr Glu Thr Leu Tyr Glu Glu Val 
             1060                1065                1070
Cys Arg Leu Glu Pro Ile Lys Val Phe Asp Gly Trp Met Lys Ile Asp 
         1075                1080                1085
Ile Arg Pro Phe Lys Ala Ser Leu Leu Asn Ile Ile Lys Arg Trp Ser 
     1090                1095                1100
Leu Leu Phe Lys Gln His Leu Val Asp His Val Thr His Ser Leu Ala 
 1105                1110                1115                1120
Asn Leu Asp Ala Phe Ile Lys Lys Ser Glu Ser Gly Leu Leu Lys Lys 
                 1125                1130                1135
Val Glu Lys Gly Asp Phe Gln Gly Leu Val Glu Ile Met Gly His Leu 
             1140                1145                1150
Met Ala Val Lys Glu Arg Gln Ser Asn Thr Asp Glu Met Phe Glu Pro 
         1155                1160                1165
Leu Lys Gln Thr Ile Glu Leu Leu Lys Thr Tyr Glu Gln Glu Leu Pro 
     1170                1175                1180
Glu Thr Val Phe Lys Gln Leu Glu Glu Leu Pro Glu Lys Trp Asn Asn 
 1185                1190                1195                1200
Ile Lys Lys Val Ala Ile Thr Val Lys Gln Gln Val Ala Pro Leu Gln 
                 1205                1210                1215
Ala Asn Glu Val Thr Leu Leu Arg Gln Arg Cys Thr Ala Phe Asp Ala 
             1220                1225                1230
Glu Gln Gln Gln Phe Trp Glu Gln Phe His Lys Glu Ala Pro Phe Arg 
         1235                1240                1245
Phe Asp Ser Ile His Pro His Gln Met Leu Asp Ala Arg His Ile Glu 
     1250                1255                1260
Ile Gln Gln Met Glu Ser Thr Met Ala Ser Ile Ser Glu Ser Ala Ser 
 1265                1270                1275                1280
Leu Phe Glu Val Asn Val Pro Asp Tyr Lys Gln Leu Arg Gln Cys Arg 
                 1285                1290                1295
Lys Glu Val Cys Gln Leu Lys Glu Leu Trp Asp Thr Ile Gly Met Val 
             1300                1305                1310
Thr Ser Ser Ile His Ala Trp Glu Thr Thr Pro Trp Arg Asn Ile Asn 
         1315                1320                1325
Val Glu Ala Met Glu Leu Glu Cys Lys Gln Phe Ala Arg His Ile Arg 
     1330                1335                1340
Asn Leu Asp Lys Glu Val Arg Ala Trp Asp Ala Phe Thr Gly Leu Glu 
 1345                1350                1355                1360
Ser Thr Val Trp Asn Thr Leu Ser Ser Leu Arg Ala Val Ala Glu Leu 
                 1365                1370                1375
Gln Asn Pro Ala Ile Arg Glu Arg His Trp Arg Gln Leu Met Gln Ala 
             1380                1385                1390
Thr Gly Val Ser Phe Thr Met Asp Gln Asp Thr Thr Leu Ala His Leu 
         1395                1400                1405
Leu Gln Leu Gln Leu His His Tyr Glu Asp Glu Val Arg Gly Ile Val 
     1410                1415                1420
Asp Lys Ala Ala Lys Glu Met Gly Met Glu Lys Thr Leu Lys Glu Leu 
 1425                1430                1435                1440
Gln Thr Thr Trp Ala Gly Met Glu Phe Gln Tyr Glu Pro His Pro Arg 
                 1445                1450                1455
Thr Asn Val Pro Leu Leu Cys Ser Asp Glu Asp Leu Ile Glu Val Leu 
             1460                1465                1470
Glu Asp Asn Gln Val Gln Leu Gln Asn Leu Val Met Ser Lys Tyr Val 
         1475                1480                1485
Ala Phe Phe Leu Glu Glu Val Ser Gly Trp Gln Lys Lys Leu Ser Thr 
     1490                1495                1500
Val Asp Ala Val Ile Ser Ile Trp Phe Glu Val Gln Arg Thr Trp Thr 
 1505                1510                1515                1520
His Leu Glu Ser Ile Phe Thr Gly Ser Glu Asp Ile Arg Ala Gln Leu 
                 1525                1530                1535
Pro Gln Asp Ser Lys Arg Phe Glu Gly Ile Asp Ile Asp Phe Lys Glu 
             1540                1545                1550
Leu Ala Tyr Asp Ala Gln Lys Ile Pro Asn Val Val Gln Thr Thr Asn 
         1555                1560                1565
Lys Pro Gly Leu Tyr Glu Lys Leu Glu Asp Ile Gln Gly Arg Leu Cys 
     1570                1575                1580
Leu Cys Glu Lys Ala Leu Ala Glu Tyr Leu Asp Thr Lys Arg Leu Ala 
 1585                1590                1595                1600
Phe Pro Arg Phe Tyr Phe Leu Ser Ser Ser Asp Leu Leu Asp Ile Leu 
                 1605                1610                1615
Ser Asn Gly Thr Ala Pro Gln Gln Val Gln Arg His Leu Ser Lys Leu 
             1620                1625                1630
Phe Asp Asn Met Ala Lys Met Arg Phe Gln Leu Asp Ala Ser Gly Glu 
         1635                1640                1645
Pro Thr Lys Thr Ser Leu Gly Met Tyr Ser Lys Glu Glu Glu Tyr Val 
     1650                1655                1660
Ala Phe Ser Glu Pro Cys Asp Cys Ser Gly Gln Val Glu Ile Trp Leu 
 1665                1670                1675                1680
Asn His Val Leu Gly His Met Lys Ala Thr Val Arg His Glu Met Thr 
                 1685                1690                1695
Glu Gly Val Thr Ala Tyr Glu Glu Lys Pro Arg Glu Gln Trp Leu Phe 
             1700                1705                1710
Asp His Pro Ala Gln Val Ala Leu Thr Cys Thr Gln Ile Trp Trp Thr 
         1715                1720                1725
Thr Glu Val Gly Met Ala Phe Ala Arg Leu Glu Glu Gly Tyr Glu Ser 
     1730                1735                1740
Ala Met Lys Asp Tyr Tyr Lys Lys Gln Val Ala Gln Leu Lys Thr Leu 
 1745                1750                1755                1760
Ile Thr Met Leu Ile Gly Gln Leu Ser Lys Gly Asp Arg Gln Lys Ile 
                 1765                1770                1775
Met Thr Ile Cys Thr Ile Asp Val His Ala Arg Asp Val Val Ala Lys 
             1780                1785                1790
Met Ile Ala Gln Lys Val Asp Asn Ala Gln Ala Phe Leu Trp Leu Ser 
         1795                1800                1805
Gln Leu Arg His Arg Trp Asp Asp Glu Val Lys His Cys Phe Ala Asn 
     1810                1815                1820
Ile Cys Asp Ala Gln Phe Leu Tyr Ser Tyr Glu Tyr Leu Gly Asn Thr 
 1825                1830                1835                1840
Pro Arg Leu Val Ile Thr Pro Leu Thr Asp Arg Cys Tyr Ile Thr Leu 
                 1845                1850                1855
Thr Gln Ser Leu His Leu Thr Met Ser Gly Ala Pro Ala Gly Pro Ala 
             1860                1865                1870
Gly Thr Gly Lys Thr Glu Thr Thr Lys Asp Leu Gly Arg Ala Leu Gly 
         1875                1880                1885
Ile Leu Val Tyr Val Phe Asn Cys Ser Glu Gln Met Asp Tyr Lys Ser 
     1890                1895                1900
Cys Gly Asn Ile Tyr Lys Gly Leu Ala Gln Thr Gly Ala Trp Gly Cys 
 1905                1910                1915                1920
Phe Asp Glu Phe Asn Arg Ile Ser Val Glu Val Leu Ser Val Val Ala 
                 1925                1930                1935
Val Gln Val Lys Ser Ile Gln Asp Ala Ile Arg Asp Lys Lys Gln Trp 
             1940                1945                1950
Phe Ser Phe Leu Gly Glu Glu Ile Ser Leu Asn Pro Ser Val Gly Ile 
         1955                1960                1965
Phe Ile Thr Met Asn Pro Gly Tyr Ala Gly Arg Thr Glu Leu Pro Glu 
     1970                1975                1980
Asn Leu Lys Ser Leu Phe Arg Pro Cys Ala Met Val Val Pro Asp Phe 
 1985                1990                1995                2000
Glu Leu Ile Cys Glu Ile Met Leu Val Ala Glu Gly Phe Ile Glu Ala 
                 2005                2010                2015
Gln Ser Leu Ala Arg Lys Phe Ile Thr Leu Tyr Gln Leu Cys Lys Glu 
             2020                2025                2030
Leu Leu Ser Lys Gln Asp His Tyr Asp Trp Gly Leu Arg Ala Ile Lys 
         2035                2040                2045
Ser Val Leu Val Val Ala Gly Ser Leu Lys Arg Gly Asp Pro Asp Arg 
     2050                2055                2060
Pro Glu Asp Gln Val Leu Met Arg Ser Leu Arg Asp Phe Asn Ile Pro 
 2065                2070                2075                2080
Lys Ile Val Thr Asp Asp Met Pro Ile Phe Met Gly Leu Ile Gly Asp 
                 2085                2090                2095
Leu Phe Pro Ala Leu Asp Val Pro Arg Arg Arg Asp Pro Asn Phe Glu 
             2100                2105                2110
Ala Leu Val Arg Lys Ala Ile Val Asp Leu Lys Leu Gln Ala Glu Asp 
         2115                2120                2125
Asn Phe Val Leu Lys Val Val Gln Leu Glu Glu Leu Leu Ala Val Arg 
     2130                2135                2140
His Ser Val Phe Val Val Gly Gly Ala Gly Thr Gly Lys Ser Gln Val 
 2145                2150                2155                2160
Leu Arg Ser Leu His Lys Thr Tyr Gln Ile Met Lys Arg Arg Pro Val 
                 2165                2170                2175
Trp Thr Asp Leu Asn Pro Lys Ala Val Thr Asn Asp Glu Leu Phe Gly 
             2180                2185                2190
Ile Ile Asn Pro Ala Thr Gly Glu Trp Lys Asp Gly Leu Phe Ser Ser 
         2195                2200                2205
Ile Met Arg Glu Leu Ala Asn Ile Thr His Asp Gly Pro Lys Trp Ile 
     2210                2215                2220
Leu Leu Asp Gly Asp Ile Asp Pro Met Trp Ile Glu Ser Leu Asn Thr 
 2225                2230                2235                2240
Val Met Asp Asp Asn Lys Val Leu Thr Leu Ala Ser Asn Glu Arg Ile 
                 2245                2250                2255
Pro Leu Asn Pro Thr Met Lys Leu Leu Phe Glu Ile Ser His Leu Arg 
             2260                2265                2270
Thr Ala Thr Pro Ala Thr Val Ser Arg Ala Gly Ile Leu Tyr Ile Asn 
         2275                2280                2285
Pro Ala Asp Leu Gly Trp Asn Pro Pro Val Ser Ser Trp Ile Glu Lys 
     2290                2295                2300
Arg Glu Ile Gln Thr Glu Arg Ala Asn Leu Thr Ile Leu Phe Asp Lys 
 2305                2310                2315                2320
Tyr Leu Pro Thr Cys Leu Asp Thr Leu Arg Thr Arg Phe Lys Lys Ile 
                 2325                2330                2335
Ile Pro Ile Pro Glu Gln Ser Met Val Gln Met Val Cys His Leu Leu 
             2340                2345                2350
Glu Cys Leu Leu Thr Thr Glu Asp Ile Pro Ala Asp Cys Pro Lys Glu 
         2355                2360                2365
Ile Tyr Glu His Tyr Phe Val Phe Ala Ala Ile Trp Ala Phe Gly Gly 
     2370                2375                2380
Ala Met Val Gln Asp Gln Leu Val Asp Tyr Arg Ala Glu Phe Ser Lys 
 2385                2390                2395                2400
Trp Trp Leu Thr Glu Phe Lys Thr Val Lys Phe Pro Ser Gln Gly Thr 
                 2405                2410                2415
Ile Phe Asp Tyr Tyr Ile Asp Pro Glu Thr Lys Lys Phe Glu Pro Trp 
             2420                2425                2430
Ser Lys Leu Val Pro Gln Phe Glu Phe Asp Pro Glu Met Pro Leu Gln 
         2435                2440                2445
Ala Cys Leu Val His Thr Ser Glu Thr Ile Arg Val Cys Tyr Phe Met 
     2450                2455                2460
Glu Arg Leu Met Ala Arg Gln Arg Pro Val Met Leu Val Gly Thr Ala 
 2465                2470                2475                2480
Gly Thr Gly Lys Ser Val Leu Val Gly Ala Lys Leu Ala Ser Leu Asp 
                 2485                2490                2495
Pro Glu Ala Tyr Leu Val Lys Asn Leu Pro Phe Asn Tyr Tyr Thr Thr 
             2500                2505                2510
Ser Ala Met Leu Gln Ala Val Leu Glu Lys Pro Leu Glu Lys Lys Ala 
         2515                2520                2525
Gly Arg Asn Tyr Gly Pro Pro Gly Asn Lys Lys Leu Ile Tyr Phe Ile 
     2530                2535                2540
Asp Asp Met Asn Met Pro Glu Val Asp Ala Tyr Gly Thr Val Gln Pro 
 2545                2550                2555                2560
His Thr Ile Ile Arg Gln His Leu Asp Tyr Gly His Trp Tyr Asp Arg 
                 2565                2570                2575
Ser Lys Leu Ser Leu Lys Glu Ile Thr Asn Val Gln Tyr Val Ser Cys 
             2580                2585                2590
Met Asn Pro Thr Ala Gly Ser Phe Thr Ile Asn Pro Arg Leu Gln Arg 
         2595                2600                2605
His Phe Ser Val Phe Val Leu Ser Phe Pro Gly Ala Asp Ala Leu Ser 
     2610                2615                2620
Ser Ile Tyr Ser Ile Ile Leu Thr Gln His Leu Lys Leu Gly Asn Phe 
 2625                2630                2635                2640
Pro Ala Ser Leu Gln Lys Ser Ile Pro Pro Leu Ile Asp Leu Ala Leu 
                 2645                2650                2655
Ala Phe His Gln Lys Ile Ala Thr Thr Phe Leu Pro Thr Gly Ile Lys 
             2660                2665                2670
Phe His Tyr Ile Phe Asn Leu Arg Asp Phe Ala Asn Ile Phe Gln Gly 
         2675                2680                2685
Ile Leu Phe Ser Ser Val Glu Cys Val Lys Ser Thr Trp Asp Leu Ile 
     2690                2695                2700
Arg Leu Tyr Leu His Glu Ser Asn Arg Val Tyr Arg Asp Lys Met Val 
 2705                2710                2715                2720
Glu Glu Lys Asp Phe Asp Leu Phe Asp Lys Ile Gln Thr Glu Val Leu 
                 2725                2730                2735
Lys Lys Thr Phe Asp Asp Ile Glu Asp Pro Val Glu Gln Thr Gln Ser 
             2740                2745                2750
Pro Asn Leu Tyr Cys His Phe Ala Asn Gly Ile Gly Glu Pro Lys Tyr 
         2755                2760                2765
Met Pro Val Gln Ser Trp Glu Leu Leu Thr Gln Thr Leu Val Glu Ala 
     2770                2775                2780
Leu Glu Asn His Asn Glu Val Asn Thr Val Met Asp Leu Val Leu Phe 
 2785                2790                2795                2800
Glu Asp Ala Met Arg His Val Cys His Ile Asn Arg Ile Leu Glu Ser 
                 2805                2810                2815
Pro Arg Gly Asn Ala Leu Leu Val Gly Val Gly Gly Ser Gly Lys Gln 
             2820                2825                2830
Ser Leu Thr Arg Leu Ala Ala Phe Ile Ser Ser Met Asp Val Phe Gln 
         2835                2840                2845
Ile Thr Leu Arg Lys Gly Tyr Gln Ile Gln Asp Phe Lys Met Asp Leu 
     2850                2855                2860
Ala Ser Leu Cys Leu Lys Ala Gly Val Lys Asn Leu Asn Thr Val Phe 
 2865                2870                2875                2880
Leu Met Thr Asp Ala Gln Val Ala Asp Glu Arg Phe Leu Val Leu Ile 
                 2885                2890                2895
Asn Asp Leu Leu Ala Ser Gly Glu Ile Pro Asp Leu Tyr Ser Asp Asp 
             2900                2905                2910
Glu Val Glu Asn Ile Ile Ser Asn Val Arg Asn Glu Val Lys Ser Gln 
         2915                2920                2925
Gly Leu Val Asp Asn Arg Glu Asn Cys Trp Lys Phe Phe Ile Asp Arg 
     2930                2935                2940
Ile Arg Arg Gln Leu Lys Val Thr Leu Cys Phe Ser Pro Val Gly Asn 
 2945                2950                2955                2960
Lys Leu Arg Val Arg Ser Arg Lys Phe Pro Ala Ile Val Asn Cys Thr 
                 2965                2970                2975
Ala Ile His Trp Phe His Glu Trp Pro Gln Gln Ala Leu Glu Ser Val 
             2980                2985                2990
Ser Leu Arg Phe Leu Gln Asn Thr Glu Gly Ile Glu Pro Thr Val Lys 
         2995                3000                3005
Gln Ser Ile Ser Lys Phe Met Ala Phe Val His Thr Ser Val Asn Gln 
     3010                3015                3020
Thr Ser Gln Ser Tyr Leu Ser Asn Glu Gln Arg Tyr Asn Tyr Thr Thr 
 3025                3030                3035                3040
Pro Lys Ser Phe Leu Glu Phe Ile Arg Leu Tyr Gln Ser Leu Leu His 
                 3045                3050                3055
Arg His Arg Lys Glu Leu Lys Cys Lys Thr Glu Arg Leu Glu Asn Gly 
             3060                3065                3070
Leu Leu Lys Leu His Ser Thr Ser Ala Gln Val Asp Asp Leu Lys Ala 
         3075                3080                3085
Lys Leu Ala Ala Gln Glu Val Glu Leu Lys Gln Lys Asn Glu Asp Ala 
     3090                3095                3100
Asp Lys Leu Ile Gln Val Val Gly Val Glu Thr Asp Lys Val Ser Arg 
 3105                3110                3115                3120
Glu Lys Ala Met Ala Asp Glu Glu Glu Gln Lys Val Ala Val Ile Met 
                 3125                3130                3135
Leu Glu Val Lys Gln Lys Gln Lys Asp Cys Glu Glu Asp Leu Ala Lys 
             3140                3145                3150
Ala Glu Pro Ala Leu Thr Ala Ala Gln Ala Ala Leu Asn Thr Leu Asn 
         3155                3160                3165
Lys Thr Asn Leu Thr Glu Leu Lys Ser Phe Gly Ser Pro Pro Leu Ala 
     3170                3175                3180
Val Ser Asn Val Ser Ala Ala Val Met Val Leu Met Ala Pro Arg Gly 
 3185                3190                3195                3200
Arg Val Pro Lys Asp Arg Ser Trp Lys Ala Ala Lys Val Thr Met Ala 
                 3205                3210                3215
Lys Val Asp Gly Phe Leu Asp Ser Leu Ile Asn Phe Asn Lys Glu Asn 
             3220                3225                3230
Ile His Glu Asn Cys Leu Lys Ala Ile Arg Pro Tyr Leu Gln Asp Pro 
         3235                3240                3245
Glu Phe Asn Pro Glu Phe Val Ala Thr Lys Ser Tyr Ala Ala Ala Gly 
     3250                3255                3260
Leu Cys Ser Trp Val Ile Asn Ile Val Arg Phe Tyr Glu Val Phe Cys 
 3265                3270                3275                3280
Asp Val Glu Pro Lys Arg Gln Ala Leu Asn Lys Ala Thr Ala Asp Leu 
                 3285                3290                3295
Thr Ala Ala Gln Glu Lys Leu Ala Ala Ile Lys Ala Lys Ile Ala His 
             3300                3305                3310
Leu Asn Glu Asn Leu Ala Lys Leu Thr Ala Arg Phe Glu Lys Ala Thr 
         3315                3320                3325
Ala Asp Lys Leu Lys Cys Gln Gln Glu Ala Glu Val Thr Ala Val Thr 
     3330                3335                3340
Ile Ser Leu Ala Asn Arg Leu Val Gly Gly Leu Ala Ser Glu Asn Val 
 3345                3350                3355                3360
Arg Trp Ala Asp Ala Val Gln Asn Phe Lys Gln Gln Glu Arg Thr Leu 
                 3365                3370                3375
Cys Gly Asp Ile Leu Leu Ile Thr Ala Phe Ile Ser Tyr Leu Gly Phe 
             3380                3385                3390
Phe Thr Lys Lys Tyr Arg Gln Ser Leu Leu Asp Arg Thr Trp Arg Pro 
         3395                3400                3405
Tyr Leu Ser Gln Leu Lys Thr Pro Ile Pro Val Thr Pro Ala Leu Asp 
     3410                3415                3420
Pro Leu Arg Met Leu Met Asp Asp Ala Asp Val Ala Ala Trp Gln Asn 
 3425                3430                3435                3440
Glu Gly Leu Pro Ala Asp Arg Met Ser Val Glu Asn Ala Thr Ile Leu 
                 3445                3450                3455
Ile Asn Cys Glu Arg Trp Pro Leu Met Val Asp Pro Gln Leu Gln Gly 
             3460                3465                3470
Ile Lys Trp Ile Lys Asn Lys Tyr Gly Glu Asp Leu Arg Val Thr Gln 
         3475                3480                3485
Ile Gly Gln Lys Gly Tyr Leu Gln Ile Ile Glu Gln Ala Leu Glu Ala 
     3490                3495                3500
Gly Ala Val Val Leu Ile Glu Asn Leu Glu Glu Ser Ile Asp Pro Val 
 3505                3510                3515                3520
Leu Gly Pro Leu Leu Gly Arg Glu Val Ile Lys Lys Gly Arg Phe Ile 
                 3525                3530                3535
Lys Ile Gly Asp Lys Glu Cys Glu Tyr Asn Pro Lys Phe Arg Leu Ile 
             3540                3545                3550
Leu His Thr Lys Leu Ala Asn Pro His Tyr Gln Pro Glu Leu Gln Ala 
         3555                3560                3565
Gln Ala Thr Leu Ile Asn Phe Thr Val Thr Arg Asp Gly Leu Glu Asp 
     3570                3575                3580
Gln Leu Leu Ala Ala Val Val Ser Met Glu Arg Pro Asp Leu Glu Gln 
 3585                3590                3595                3600
Leu Lys Ser Asp Leu Thr Lys Gln Gln Asn Gly Phe Lys Ile Thr Leu 
                 3605                3610                3615
Lys Thr Leu Glu Asp Ser Leu Leu Ser Arg Leu Ser Ser Ala Ser Gly 
             3620                3625                3630
Asn Phe Leu Gly Glu Thr Val Leu Val Glu Asn Leu Glu Ile Thr Lys 
         3635                3640                3645
Gln Thr Ala Ala Glu Val Glu Lys Lys Val Gln Glu Ala Lys Val Thr 
     3650                3655                3660
Glu Val Lys Ile Asn Glu Ala Arg Glu His Tyr Arg Pro Thr Ala Ala 
 3665                3670                3675                3680
Arg Ala Ser Leu Leu Tyr Phe Ile Met Asn Asp Leu Ser Lys Ile His 
                 3685                3690                3695
Pro Met Tyr Gln Phe Ser Leu Lys Ala Phe Ser Ile Val Phe Gln Lys 
             3700                3705                3710
Ala Val Glu Arg Ala Ala Pro Asp Glu Ser Leu Arg Glu Arg Val Ala 
         3715                3720                3725
Asn Leu Ile Asp Ser Ile Thr Phe Ser Val Tyr Gln Tyr Thr Ile Arg 
     3730                3735                3740
Gly Leu Phe Glu Cys Asp Lys Leu Thr Tyr Leu Ala Gln Leu Thr Phe 
 3745                3750                3755                3760
Gln Ile Leu Leu Met Asn Arg Glu Val Asn Ala Val Glu Leu Asp Phe 
                 3765                3770                3775
Leu Leu Arg Ser Pro Val Gln Thr Gly Thr Ala Ser Pro Val Glu Phe 
             3780                3785                3790
Leu Ser His Gln Ala Trp Gly Ala Val Lys Val Leu Ser Ser Met Glu 
         3795                3800                3805
Glu Phe Ser Asn Leu Asp Arg Asp Ile Glu Gly Ser Ala Lys Ser Trp 
     3810                3815                3820
Lys Lys Phe Val Glu Ser Glu Cys Pro Glu Lys Glu Lys Leu Pro Gln 
 3825                3830                3835                3840
Glu Trp Lys Asn Lys Thr Ala Leu Gln Arg Leu Cys Met Leu Arg Ala 
                 3845                3850                3855
Met Arg Pro Asp Arg Met Thr Tyr Ala Leu Arg Asp Phe Val Glu Glu 
             3860                3865                3870
Lys Leu Gly Ser Lys Tyr Val Val Gly Arg Ala Leu Asp Phe Ala Thr 
         3875                3880                3885
Ser Phe Glu Glu Ser Gly Pro Ala Thr Pro Met Phe Phe Ile Leu Ser 
     3890                3895                3900
Pro Gly Val Asp Pro Leu Lys Asp Val Glu Ser Gln Gly Arg Lys Leu 
 3905                3910                3915                3920
Gly Tyr Thr Phe Asn Asn Gln Asn Phe His Asn Val Ser Leu Gly Gln 
                 3925                3930                3935
Gly Gln Glu Val Val Ala Glu Ala Ala Leu Asp Leu Ala Ala Lys Lys 
             3940                3945                3950
Gly His Trp Val Ile Leu Gln Asn Ile His Leu Val Ala Lys Trp Leu 
         3955                3960                3965
Ser Thr Leu Glu Lys Lys Leu Glu Glu His Ser Glu Asn Ser His Pro 
     3970                3975                3980
Glu Phe Arg Val Phe Met Ser Ala Glu Pro Ala Pro Ser Pro Glu Gly 
 3985                3990                3995                4000
His Ile Ile Pro Gln Gly Ile Leu Glu Asn Ser Ile Lys Ile Thr Asn 
                 4005                4010                4015
Glu Pro Pro Thr Gly Met His Ala Asn Leu His Lys Ala Leu Asp Asn 
             4020                4025                4030
Phe Thr Gln Asp Thr Leu Glu Met Cys Ser Arg Glu Thr Glu Phe Lys 
         4035                4040                4045
Ser Ile Leu Phe Ala Leu Cys Tyr Phe His Ala Val Val Ala Glu Arg 
     4050                4055                4060
Arg Lys Phe Gly Pro Gln Gly Trp Asn Arg Ser Tyr Pro Phe Asn Thr 
 4065                4070                4075                4080
Gly Asp Leu Thr Ile Ser Val Asn Val Leu Tyr Asn Phe Leu Glu Ala 
                 4085                4090                4095
Asn Ala Lys Val Pro Tyr Asp Asp Leu Arg Tyr Leu Phe Gly Glu Ile 
             4100                4105                4110
Met Tyr Gly Gly His Ile Thr Asp Asp Trp Asp Arg Arg Leu Cys Arg 
         4115                4120                4125
Thr Tyr Leu Gly Glu Phe Ile Arg Pro Glu Met Leu Glu Gly Glu Leu 
     4130                4135                4140
Ser Leu Ala Pro Gly Phe Pro Leu Pro Gly Asn Met Asp Tyr Asn Gly 
 4145                4150                4155                4160
Tyr His Gln Tyr Ile Asp Ala Glu Leu Pro Pro Glu Ser Pro Tyr Leu 
                 4165                4170                4175
Tyr Gly Leu His Pro Asn Ala Glu Ile Gly Phe Leu Thr Gln Thr Ser 
             4180                4185                4190
Glu Lys Leu Phe Arg Thr Val Leu Glu Leu Gln Pro Arg Asp Ser Gln 
         4195                4200                4205
Ala Arg Asp Gly Ala Gly Ala Thr Arg Glu Glu Lys Val Lys Ala Leu 
     4210                4215                4220
Leu Glu Glu Ile Leu Glu Arg Val Thr Asp Glu Phe Asn Ile Pro Glu 
 4225                4230                4235                4240
Leu Met Ala Lys Val Glu Glu Arg Thr Pro Tyr Ile Val Val Ala Phe 
                 4245                4250                4255
Gln Glu Cys Gly Arg Met Asn Ile Leu Thr Arg Glu Ile Gln Arg Ser 
             4260                4265                4270
Leu Arg Glu Leu Glu Leu Gly Leu Lys Gly Glu Leu Thr Met Thr Ser 
         4275                4280                4285
His Met Glu Asn Leu Gln Asn Ala Leu Tyr Phe Asp Met Val Pro Glu 
     4290                4295                4300
Ser Trp Ala Arg Arg Ala Tyr Pro Ser Thr Ala Gly Leu Ala Ala Trp 
 4305                4310                4315                4320
Phe Pro Asp Leu Leu Asn Arg Ile Lys Glu Leu Glu Ala Trp Thr Gly 
                 4325                4330                4335
Asp Phe Thr Met Pro Ser Thr Val Trp Leu Thr Gly Phe Phe Asn Pro 
             4340                4345                4350
Gln Ser Phe Leu Thr Ala Ile Met Gln Ser Thr Ala Arg Lys Asn Glu 
         4355                4360                4365
Trp Pro Leu Asp Gln Ile Ala Leu Gln Cys Asp Met Thr Lys Lys Asn 
     4370                4375                4380
Arg Glu Glu Phe Arg Ser Pro Pro Arg Glu Gly Ala Tyr Ile His Gly 
 4385                4390                4395                4400
Leu Phe Met Glu Gly Ala Cys Trp Asp Thr Gln Ala Gly Ile Ile Thr 
                 4405                4410                4415
Glu Ala Lys Leu Lys Asp Leu Thr Pro Pro Met Pro Val Met Phe Ile 
             4420                4425                4430
Lys Ala Ile Pro Ala Asp Lys Gln Asp Cys Arg Ser Val Tyr Ser Cys 
         4435                4440                4445
Pro Val Tyr Lys Thr Ser Gln Arg Gly Pro Thr Tyr Val Trp Thr Phe 
     4450                4455                4460
Asn Leu Lys Thr Lys Glu Asn Pro Ser Lys Trp Val Leu Ala Gly Val 
 4465                4470                4475                4480
Ala Leu Leu Leu Gln Ile 
                 4485



<210> 1905
<211> 2096
<212> DNA
<213> Rattus norvegicus
<308> D28512
<400> 1905

gctcgtcca  cctgcaacc  ccatgggct  ccgcccccc  cctcctcgg  tgccaccca  60
gacaaggca  ggataagca  agtgtagga  cacgtggcc  ctatgtctg  ggactacga  120
gatgacctc  gtcggcggg  cctcatcct  gtttcagac  tctgtgcac  gatccgaga  180
gctgatacc  atgacaggt  tcaagagtt  aacgaactg  gaatcagag  atatccccg  240
ggtccggat  cagacattt  cgtgagcct  ctgtcagtc  tcgtgacgt  ctgtggcat  300
gtcctcttg  gtgtctctc  cttcgtgtc  tggaagttg  gctgggtgc  ctggaggga  360
aaagggggc  cagcagtgg  tggtggccc  ctgcgcaaa  acttagccc  tggggttgg  420
ctggcaggc  tggtaggag  tggtgggca  catctggga  ccagcctag  tggccatcc  480
ctgctgggt  gtccgcacc  tcatgcaca  ccagcccac  atccaccat  tgctgaact  540
ctggaacca  gtggccttg  gggctctga  cctccagaa  cttcctacc  ggacatgga  600
tcatatcca  aggctgctg  ggcctctgt  gtagctgct  gggtcaaac  aagccagac  660
tcccctgag  tgccttctg  gggtggaac  ggctctggg  tgctcctgc  gcctcctag  720
ggtgggggc  tgcccagtg  ccagtctca  cagcaggtc  caagtctag  acccaccac  780
aggtaccca  ccctgcctc  gcccctcac  cagcagacc  tgaccaccc  agcagaccc  840
agcagtgag  agcgaccac  tgcactgcc  ttacccctg  caggcggag  ggagaaagc  900
aagctcatc  gtcagatca  gccagagct  taccagggc  ctggacctg  tggccggcg  960
acgggcggg  gctctgggg  ggcaggggc  ccctgtggc  gcatcagtt  tgcccttcg  1020
tacctctat  gctctgacc  gctcgtggt  cggatcctt  aggccctgg  tctcccagc  1080
aaggactcc  atgggttct  agaccccta  gtcaagatc  acctgttgc  tgatcgcaa  1140
aagaagttc  agaccaagg  gcacaggaa  acgctgaac  ctatcttca  cgagacgtt  1200
cagttttcg  tacccttgg  cgagctggc  cagcgcaag  tgcacttca  tgtctatga  1260
ttcgacaga  tctcgaggc  cgatctcat  ggccaggtg  ttttggaca  cctgctgga  1320
cttgctgaa  agccccctg  ccgtccact  tggagggac  tcctggagg  tggctcgga  1380
aaggcagat  ttggggagc  caacttctc  ctctgctac  tccccacgg  cgggctcct  1440
accgtgacc  tcatcaaag  ctctaacct  aaagcaatg  acctcactg  tttctcaga  1500
ccctacgtg  aggcctctc  gatcagcga  gggcggcgt  tgaagaaac  gaagacctc  1560
attaagaag  acacgctga  ccccacata  aacgaggcc  tggtgttcg  cgtggctcc  1620
gagagcgtg  agaacgtgg  tctcagtat  gcagtggta  actatgact  catcggcca  1680
aatgaagtg  tcggggtgt  ccgcgtggg  ccagaggcc  ctgacccac  tggcagaga  1740
cactgggca  agatgctgg  taaccctcg  aagcctgtg  agcactggc  ccagctagt  1800
gaggagaag  ctctaagca  ctttaccaa  ggcggcaaa  gattgtcag  gaaagagaa  1860
tcagagtga  ggtctggtc  aggcctggg  ttggaccag  cgccctcag  acccatccc  1920
tcctgcccg  actgtgaac  catctcgaa  ccataatgt  cgagctgct  gtgcggggc  1980
gcctggacc  gttcctcct  atcctggag  cgtgaggct  ggaggcagc  ggcccagct  2040
cctgtttca  ggtgggagg  tctcggcct  cattgtctg  cttcttatc  ccagag  2096



<210> 1906
<211> 588
<212> PRT
<213> Rattus norvegicus
<308> P40748
<400> 1906

Met Ser Gly Asp Tyr Glu Asp Asp Leu Cys Arg Arg Ala Leu Ile Leu 
  1               5                  10                  15
Val Ser Asp Leu Cys Ala Arg Ile Arg Asp Ala Asp Thr Asn Asp Arg 
             20                  25                  30
Cys Gln Glu Phe Asn Glu Leu Arg Ile Arg Gly Tyr Pro Arg Gly Pro 
         35                  40                  45
Asp Ala Asp Ile Ser Val Ser Leu Leu Ser Val Ile Val Thr Phe Cys 
     50                  55                  60
Gly Ile Val Leu Leu Gly Val Ser Leu Phe Val Ser Trp Lys Leu Cys 
 65                  70                  75                  80
Trp Val Pro Trp Arg Asp Lys Gly Gly Ser Ala Val Gly Gly Gly Pro 
                 85                  90                  95
Leu Arg Lys Asp Leu Ala Pro Gly Val Gly Leu Ala Gly Leu Val Gly 
             100                105                110
Gly Gly Gly His His Leu Gly Ala Ser Leu Gly Gly His Pro Leu Leu 
         115                120                125
Gly Gly Pro His His His Ala His Pro Ala His His Pro Pro Phe Ala 
     130                135                140
Glu Leu Leu Glu Pro Gly Gly Leu Gly Gly Ser Glu Pro Pro Glu Pro 
 145                150                155                160
Ser Tyr Leu Asp Met Asp Ser Tyr Pro Glu Ala Ala Val Ala Ser Val 
                 165                170                175
Val Ala Ala Gly Val Lys Pro Ser Gln Thr Ser Pro Glu Leu Pro Ser 
             180                185                190
Glu Gly Gly Thr Gly Ser Gly Leu Leu Leu Leu Pro Pro Ser Gly Gly 
         195                200                205
Gly Leu Pro Ser Ala Gln Ser His Gln Gln Val Thr Ser Leu Ala Pro 
     210                215                220
Thr Thr Arg Tyr Pro Ala Leu Pro Arg Pro Leu Thr Gln Gln Thr Leu 
 225                230                235                240
Thr Thr Gln Ala Asp Pro Ser Ser Glu Glu Arg Pro Pro Ala Leu Pro 
                 245                250                255
Leu Pro Leu Pro Gly Gly Glu Glu Lys Ala Lys Leu Ile Gly Gln Ile 
             260                265                270
Lys Pro Glu Leu Tyr Gln Gly Thr Gly Pro Gly Gly Arg Arg Thr Gly 
         275                280                285
Gly Gly Ser Gly Glu Ala Gly Ala Pro Cys Gly Arg Ile Ser Phe Ala 
     290                295                300
Leu Arg Tyr Leu Tyr Gly Ser Asp Gln Leu Val Val Arg Ile Leu Gln 
 305                310                315                320
Ala Leu Asp Leu Pro Ala Lys Asp Ser Asn Gly Phe Ser Asp Pro Tyr 
                 325                330                335
Val Lys Ile Tyr Leu Leu Pro Asp Arg Lys Lys Lys Phe Gln Thr Lys 
             340                345                350
Val His Arg Lys Thr Leu Asn Pro Ile Phe Asn Glu Thr Phe Gln Phe 
         355                360                365
Ser Val Pro Leu Ala Glu Leu Ala Gln Arg Lys Leu His Phe Ser Val 
     370                375                380
Tyr Asp Phe Asp Arg Phe Ser Arg His Asp Leu Ile Gly Gln Val Val 
 385                390                395                400
Leu Asp Asn Leu Leu Glu Leu Ala Glu Gln Pro Pro Asp Arg Pro Leu 
                 405                410                415
Trp Arg Asp Ile Leu Glu Gly Gly Ser Glu Lys Ala Asp Leu Gly Glu 
             420                425                430
Leu Asn Phe Ser Leu Cys Tyr Leu Pro Thr Ala Gly Leu Leu Thr Val 
         435                440                445
Thr Ile Ile Lys Ala Ser Asn Leu Lys Ala Met Asp Leu Thr Gly Phe 
     450                455                460
Ser Asp Pro Tyr Val Lys Ala Ser Leu Ile Ser Glu Gly Arg Arg Leu 
 465                470                475                480
Lys Lys Arg Lys Thr Ser Ile Lys Lys Asn Thr Leu Asn Pro Thr Tyr 
                 485                490                495
Asn Glu Ala Leu Val Phe Asp Val Ala Pro Glu Ser Val Glu Asn Val 
             500                505                510
Gly Leu Ser Ile Ala Val Val Asp Tyr Asp Cys Ile Gly His Asn Glu 
         515                520                525
Val Ile Gly Val Cys Arg Val Gly Pro Glu Ala Ala Asp Pro His Gly 
     530                535                540
Arg Glu His Trp Ala Glu Met Leu Ala Asn Pro Arg Lys Pro Val Glu 
 545                550                555                560
His Trp His Gln Leu Val Glu Glu Lys Thr Leu Ser Ser Phe Thr Lys 
                 565                570                575
Gly Gly Lys Gly Leu Ser Glu Lys Glu Asn Ser Glu 
             580                585



<210> 1907
<211> 2931
<212> DNA
<213> Homo sapiens
<308> AL136594
<400> 1907

actctatgt  tcctctcgt  ggattgtga  accgggagg  cagggaact  caggacctt  60
ttctctgct  gattcgcag  aaccagcac  gcacgtagg  cgtagttgg  gctggatgg  120
tgtttgttg  atgaatgaa  gatgaatgg  tggcacctt  tctgctcat  cctaactcc  180
gttccttca  ctgtgcagc  ctaatcttt  tttcctcat  tgtccatcc  tttatttgt  240
catcctcat  cttagcccc  tcactgccc  tctccatct  ttcctcctt  ttcatttgt  300
cctgttctc  gtcctctac  ccactcatg  ccatctctg  ccccttgac  tacccagtc  360
ctgctacta  ctccatccc  aatttctgc  ctcttgtct  tctactcct  attcctttt  420
cttgtccat  cctaatacc  gtcaccttg  ccttcttcc  cgaatctcc  tccctaatc  480
atctgcccc  aatctctgt  ccctttgcc  atccttcct  ttctcggtg  ctctttcca  540
ccttatctc  acacctgcc  accctgcac  cccattctg  ttcccatct  cacccttgc  600
ccatccctc  cacacacag  accagacgg  caccatgtc  ggagactac  aggatgacc  660
ctgccggcg  gcactcatc  tggtctcgg  cctctgtgc  cgggtccga  atgctgaca  720
caacgacag  tgccaggag  tcaatgacc  aatccgagg  tatccccgg  gtccagatg  780
agacatctc  gtgagcctg  tgtcggtca  cgtgacatt  tgtggcatt  tccttctgg  840
tgtctctct  ttcgtgtcc  ggaagttgt  ctgggtgcc  tggcgggac  agggaggct  900
ggcagtggg  ggtggcccc  tgcgcaaag  cctaggccc  ggtgtcggg  tggcaggcc  960
ggtaggcgg  ggcgggcac  acctggcgg  tggcctggg  ggccatcct  tgctgggcg  1020
cccacacca  catgcccat  ccgcccacc  tccaccctt  gctgagctg  tggagccag  1080
cagcctggg  ggttctgac  cccctgagc  ctcctactt  gacatggac  cgtatccag  1140
ggctgcagc  gcagcagtg  ccgctgggg  caaaccgag  caaacatcc  ctgagctgc  1200
ctctgaggg  ggagcaggc  ctgggttgc  cctgctgcc  cccagtggt  ggggcttgc  1260
cagtgccca  tcacatcag  aggtcacaa  cctggcacc  actaccagg  acccagccc  1320
gccccgacc  ctcacccag  agactctga  ctcccagcc  gaccccagc  gtgaggagc  1380
cccacctgc  ctgccctta  ccctgcctg  aggcgagga  aaagccaaa  tcattgggc  1440
gattaagcc  gagctgtac  aggggactg  ccctggtgg  cggcggagc  gtgggggcc  1500
aggctctgg  gaggcaggc  caggggcac  ctgtggccg  atcagcttc  ccctgcggt  1560
cctctatgg  tcggaccag  tggtggtga  gatcctgca  gccctggac  tccctgcca  1620
ggactccaa  ggcttctca  acccctacg  caagatcta  ctgctgcct  accgcaaga  1680
aaagtttca  accaaggtg  acaggaaga  cctgaaccc  gtcttcaat  agacgtttc  1740
attctcggt  cccctggcc  agctggccc  acgcaaact  cacttcagc  tctatgact  1800
tgaccgctt  tcgcggcac  acctcatcg  ccaggtggt  ctggacaac  tcctggagc  1860
ggccgagca  ccccctgac  gcccgctct  gagggacat  gtggagggc  gctcggaaa  1920
agcagatct  ggggagctc  acttctcac  ctgctacct  cccacggcc  ggcgcctca  1980
cgtgaccat  atcaaagcc  ctaacctca  agcgatgga  ctcactggc  tctcagacc  2040
ctacgtgaa  gcctccctg  tcagcgagg  gcggcgtct  aagaagcgg  aaacctcca  2100
caagaagaa  acgctgaac  ccacctata  tgaggcgct  gtgttcgac  tggcccccg  2160
gagcgtgga  aacgtgggg  tcagcatcg  cgtggtgga  tacgactgc  tcgggcaca  2220
cgaggtgat  ggcgtgtgc  gtgtgggcc  cgacgctgc  gacccgcac  gccgcgagc  2280
ctgggcaga  atgctggcc  atccccgca  gcccgtgga  cactggcat  agctagtgg  2340
ggaaaagac  gtgaccagc  tcacaaaag  cagcaaagg  ctatcagag  aagagaact  2400
cgagtgagg  gtctggcct  ggcccggga  cggaccagg  tccctcagg  ccccatcct  2460
tcctgcccg  accgtgaat  catctcctt  aagccataa  gtccgagct  ctggtgcgg  2520
gcagccctg  ccctaggct  cctaaccct  gaagcgaga  gatgagagg  ggccggccc  2580
gctccttct  tcagggtgg  ggtcattca  cctccactg  gtctgtctt  tcttccctg  2640
ggctccccc  cgaggcgag  ggccatgca  gtctggggg  cccctgccc  ccaaaaccc  2700
ctgtctgtc  ctgtctctt  gctgtttgt  caagactca  tgtcccgac  cttgttctc  2760
ccgtgaatg  caatgggcc  atcctctct  tcctttcag  cacacacac  cctgtgtcc  2820
ccccttctg  tcgccacac  ctgcgtctg  ccggtcccc  cactgctgc  gctatcaac  2880
ccagaataa  cacactctg  gggtctcac  ccaaaaaaa  aaaaaaaaa  a  2931



<210> 1908
<211> 590
<212> PRT
<213> Homo sapiens
<308> Q9BQG1
<400> 1908

Met Ser Gly Asp Tyr Glu Asp Asp Leu Cys Arg Arg Ala Leu Ile Leu 
  1               5                  10                  15
Val Ser Asp Leu Cys Ala Arg Val Arg Asp Ala Asp Thr Asn Asp Arg 
             20                  25                  30
Cys Gln Glu Phe Asn Asp Arg Ile Arg Gly Tyr Pro Arg Gly Pro Asp 
         35                  40                  45
Ala Asp Ile Ser Val Ser Leu Leu Ser Val Ile Val Thr Phe Cys Gly 
     50                  55                  60
Ile Val Leu Leu Gly Val Ser Leu Phe Val Ser Trp Lys Leu Cys Trp 
 65                  70                  75                  80
Val Pro Trp Arg Asp Lys Gly Gly Ser Ala Val Gly Gly Gly Pro Leu 
                 85                  90                  95
Arg Lys Asp Leu Gly Pro Gly Val Gly Leu Ala Gly Leu Val Gly Gly 
             100                105                110
Gly Gly His His Leu Ala Ala Gly Leu Gly Gly His Pro Leu Leu Gly 
         115                120                125
Gly Pro His His His Ala His Ala Ala His His Pro Pro Phe Ala Glu 
     130                135                140
Leu Leu Glu Pro Gly Ser Leu Gly Gly Ser Asp Thr Pro Glu Pro Ser 
 145                150                155                160
Tyr Leu Asp Met Asp Ser Tyr Pro Glu Ala Ala Ala Ala Ala Val Ala 
                 165                170                175
Ala Gly Val Lys Pro Ser Gln Thr Ser Pro Glu Leu Pro Ser Glu Gly 
             180                185                190
Gly Ala Gly Ser Gly Leu Leu Leu Leu Pro Pro Ser Gly Gly Gly Leu 
         195                200                205
Pro Ser Ala Gln Ser His Gln Gln Val Thr Ser Leu Ala Pro Thr Thr 
     210                215                220
Arg Tyr Pro Ala Leu Pro Arg Pro Leu Thr Gln Gln Thr Leu Thr Ser 
 225                230                235                240
Gln Pro Asp Pro Ser Ser Glu Glu Arg Pro Pro Ala Leu Pro Leu Pro 
                 245                250                255
Leu Pro Gly Gly Glu Glu Lys Ala Lys Leu Ile Gly Gln Ile Lys Pro 
             260                265                270
Glu Leu Tyr Gln Gly Thr Gly Pro Gly Gly Arg Arg Ser Gly Gly Gly 
         275                280                285
Pro Gly Ser Gly Glu Ala Gly Thr Gly Ala Pro Cys Gly Arg Ile Ser 
     290                295                300
Phe Ala Leu Arg Tyr Leu Tyr Gly Ser Asp Gln Leu Val Val Arg Ile 
 305                310                315                320
Leu Gln Ala Leu Asp Leu Pro Ala Lys Asp Ser Asn Gly Phe Ser Asp 
                 325                330                335
Pro Tyr Val Lys Ile Tyr Leu Leu Pro Asp Arg Lys Lys Lys Phe Gln 
             340                345                350
Thr Lys Val His Arg Lys Thr Leu Asn Pro Val Phe Asn Glu Thr Phe 
         355                360                365
Gln Phe Ser Val Pro Leu Ala Glu Leu Ala Gln Arg Lys Leu His Phe 
     370                375                380
Ser Val Tyr Asp Phe Asp Arg Phe Ser Arg His Asp Leu Ile Gly Gln 
 385                390                395                400
Val Val Leu Asp Asn Leu Leu Glu Leu Ala Glu Gln Pro Pro Asp Arg 
                 405                410                415
Pro Leu Trp Arg Asp Ile Val Glu Gly Gly Ser Glu Lys Ala Asp Leu 
             420                425                430
Gly Glu Leu Asn Phe Ser Leu Cys Tyr Leu Pro Thr Ala Gly Arg Leu 
         435                440                445
Thr Val Thr Ile Ile Lys Ala Ser Asn Leu Lys Ala Met Asp Leu Thr 
     450                455                460
Gly Phe Ser Asp Pro Tyr Val Lys Ala Ser Leu Ile Ser Glu Gly Arg 
 465                470                475                480
Arg Leu Lys Lys Arg Lys Thr Ser Ile Lys Lys Asn Thr Leu Asn Pro 
                 485                490                495
Thr Tyr Asn Glu Ala Leu Val Phe Asp Val Ala Pro Glu Ser Val Glu 
             500                505                510
Asn Val Gly Leu Ser Ile Ala Val Val Asp Tyr Asp Cys Ile Gly His 
         515                520                525
Asn Glu Val Ile Gly Val Cys Arg Val Gly Pro Asp Ala Ala Asp Pro 
     530                535                540
His Gly Arg Glu His Trp Ala Glu Met Leu Ala Asn Pro Arg Lys Pro 
 545                550                555                560
Val Glu His Trp His Gln Leu Val Glu Glu Lys Thr Val Thr Ser Phe 
                 565                570                575
Thr Lys Gly Ser Lys Gly Leu Ser Glu Lys Glu Asn Ser Glu 
             580                585                590



<210> 1910
<211> 361
<212> PRT
<213> Rattus norvegicus
<308> Q62764
<400> 1910

Met Ser Glu Ala Gly Glu Ala Thr Thr Gly Gly Thr Thr Leu Pro Gln 
  1               5                  10                  15
Ala Ala Ala Asp Ala Pro Ala Ala Ala Pro Pro Asp Pro Ala Pro Lys 
             20                  25                  30
Ser Pro Ala Ala Ser Gly Ala Pro Gln Ala Pro Ala Pro Ala Ala Leu 
         35                  40                  45
Leu Ala Gly Ser Pro Gly Gly Asp Ala Ala Pro Gly Pro Ala Pro Ala 
     50                  55                  60
Ser Ser Ala Pro Ala Gly Ser Glu Asp Ala Glu Lys Lys Val Leu Ala 
 65                  70                  75                  80
Thr Lys Val Leu Gly Thr Val Lys Trp Phe Asn Val Arg Asn Gly Tyr 
                 85                  90                  95
Gly Phe Ile Asn Arg Asn Asp Thr Lys Glu Asp Val Phe Val His Gln 
             100                105                110
Thr Ala Ile Lys Lys Asn Asn Pro Arg Lys Tyr Leu Arg Ser Val Gly 
         115                120                125
Asp Gly Glu Thr Val Glu Phe Asp Val Val Glu Gly Glu Lys Gly Ala 
     130                135                140
Glu Ala Ala Asn Val Thr Gly Pro Asp Gly Val Pro Val Glu Gly Ser 
 145                150                155                160
Arg Tyr Ala Ala Asp Arg Arg Arg Tyr Arg Arg Gly Tyr Tyr Gly Arg 
                 165                170                175
Arg Arg Gly Pro Pro Arg Asn Tyr Ala Gly Glu Glu Glu Glu Glu Gly 
             180                185                190
Ser Gly Ser Ser Glu Gly Phe Glu Pro Pro Ala Ala Asp Gly Gln Phe 
         195                200                205
Ser Gly Ala Arg Asn Gln Leu Arg Arg Pro Gln Tyr Arg Pro Pro Tyr 
     210                215                220
Arg Gln Arg Arg Phe Pro Pro Tyr His Val Gly Gln Thr Phe Asp Arg 
 225                230                235                240
Arg Ser Arg Val Phe Pro His Pro Asn Arg Met Gln Ala Gly Glu Ile 
                 245                250                255
Gly Glu Met Lys Asp Gly Val Pro Glu Gly Ala Gln Leu Gln Val His 
             260                265                270
Arg Asn Pro Thr Tyr Arg Pro Arg Phe Arg Arg Gly Pro Ala Arg Pro 
         275                280                285
Arg Pro Ala Pro Ala Ile Gly Glu Ala Glu Asp Lys Glu Asn Gln Gln 
     290                295                300
Ala Ala Asn Gly Pro Asn Gln Pro Ser Ala Arg Arg Gly Phe Arg Arg 
 305                310                315                320
Pro Tyr Asn Tyr Arg Arg Arg Pro Arg Pro Leu Asn Ala Val Ser Gln 
                 325                330                335
Asp Gly Lys Glu Thr Lys Ala Gly Glu Ala Pro Thr Glu Asn Pro Ala 
             340                345                350
Pro Ala Thr Glu Gln Ser Ser Ala Glu 
         355                360



<210> 1912
<211> 241
<212> PRT
<213> Homo sapiens
<308> P20618
<400> 1912

Met Leu Ser Ser Thr Ala Met Tyr Ser Ala Pro Gly Arg Asp Leu Gly 
  1               5                  10                  15
Met Glu Pro His Arg Ala Ala Gly Pro Leu Gln Leu Arg Phe Ser Pro 
             20                  25                  30
Tyr Val Phe Asn Gly Gly Thr Ile Leu Ala Ile Ala Gly Glu Asp Phe 
         35                  40                  45
Ala Ile Val Ala Ser Asp Thr Arg Leu Ser Glu Gly Phe Ser Ile His 
     50                  55                  60
Thr Arg Asp Ser Pro Lys Cys Tyr Lys Leu Thr Asp Lys Thr Val Ile 
 65                  70                  75                  80
Gly Cys Ser Gly Phe His Gly Asp Cys Leu Thr Leu Thr Lys Ile Ile 
                 85                  90                  95
Glu Ala Arg Leu Lys Met Tyr Lys His Ser Asn Asn Lys Ala Met Thr 
             100                105                110
Thr Gly Ala Ile Ala Ala Met Leu Ser Thr Ile Leu Tyr Ser Arg Arg 
         115                120                125
Phe Phe Pro Tyr Tyr Val Tyr Asn Ile Ile Gly Gly Leu Asp Glu Glu 
     130                135                140
Gly Lys Gly Ala Val Tyr Ser Phe Asp Pro Val Gly Ser Tyr Gln Arg 
 145                150                155                160
Asp Ser Phe Lys Ala Gly Gly Ser Ala Ser Ala Met Leu Gln Pro Leu 
                 165                170                175
Leu Asp Asn Gln Val Gly Phe Lys Asn Met Gln Asn Val Glu His Val 
             180                185                190
Pro Leu Ser Leu Asp Arg Ala Met Arg Leu Val Lys Asp Val Phe Ile 
         195                200                205
Ser Ala Ala Glu Arg Asp Val Tyr Thr Gly Asp Ala Leu Arg Ile Cys 
     210                215                220
Ile Val Thr Lys Glu Gly Ile Arg Glu Glu Thr Val Ser Leu Arg Lys 
 225                230                235                240
Asp 
                 245



<210> 1913
<211> 4469
<212> DNA
<213> Rattus norvegicus
<308> D29683
<400> 1913

ctggatcaa  gctgtntac  gcccccttt  cttcttcat  aattcaccg  tgattttttcgtgcggtc  gagcgtaga  ctcagcgca  agcaccggg  gccggagcc  tagcgggag  60
tgcatccaa  gcccggccg  tcggagccc  cgagcgatg  tgtcatcct  caagcgggc  120
acgctggac  aagaggatc  ggtggactc  ctctccgag  gcgatgtgt  ccccaatgg  180
ctacaggtg  acttccgca  cccccggag  ggacagagg  gctgggcag  tcggacctc  240
gtggagaag  ggctggtgg  tctggtgac  cttctggca  cagggctgg  ggcctgcct  300
gcagcccta  gcatccagt  ccggacaag  acgcctccg  tatgtctga  tgaggcctg  360
gtctcagtg  ccagctcca  cctaaactc  atggacccc  cggtagacc  ctgccagga  420
ttcttcagc  acgcctgtg  tggctggat  aaggccaac  ccgttcccg  cggtcactc  480
cgctggggg  ccttcagca  cctctggga  cacaaccaa  ccatcatta  gcatctgct  540
gaaaattcc  cggccagcg  gagcgaggc  gagaaaaag  cgcaagtgt  ctaccgtgc  600
tgtatgaac  aaactagga  cgaggagct  cgggccaag  ccctgatgg  gctgattga  660
aagctcgga  gttggaata  cacaggacc  tgggccaag  acaacttcc  ggacacgct  720
caggtggtc  cagcgcact  ccgcacctc  cccttcttc  ctgtctatg  cagtgccga  780
tccaagaac  ccaacagca  tgtgatcca  gtggaccag  ccggccttg  cttgccctc  840
agagactat  acctgaaca  gacggaaaa  gaaaaggta  tgactggct  tctgaacta  900
atggtccag  tggggaaac  gctgggtgg  ggggacgag  actccatcc  gccccagat  960
cagcagatc  tggattttg  gaccgctct  gccaacatc  ccatccccc  ggagaagcg  1020
cgggatgaa  agctcatct  ccacaaagt  acggctgct  agctgcaga  cttggcacc  1080
gccatcaac  ggttaccct  tctgaatgc  attttttac  cagtggaga  caatgagtc  1140
gagcccatc  tggtctacg  caaggaata  ctcagacaa  tctccacac  catcaacag  1200
accgacaaa  gcctgctca  caactacat  atgtggaac  tggtacgga  aacaagctc  1260
tttctcgac  agcgctttc  ggatgccga  gagaagttc  tggaggtta  gtacgggac  1320
aagaagacc  gtcttcccc  ctggaagtt  tgcgtgagt  acacagaaa  caacctggg  1380
tttgccctg  gccccatgt  tgtgaaagc  acctttgcg  aggacagca  gaacatagc  1440
agcgagatc  tcctggaga  caagaaggc  ttcgaggag  gcctgagca  cctgaaatg  1500
atggatgaa  atactcgga  gtcagccaa  gagaaggcg  acgccatct  caacatgat  1560
ggctacccc  acttcatca  ggaccccaa  gagctggac  aagtgttca  tgactacac  1620
gcagttccc  atctctact  tgagaacgc  atgcgattt  tcaacttct  attgagggt  1680
acagccgac  agctcagga  agcccccaa  agagatcag  ggagtatga  cccgcccat  1740
gtgaacgcc  actactcgc  caccaagaa  gagattgtg  ttccagctg  aatcctgca  1800
gcgccattt  atacccgct  ttcgcccaa  gccttgaac  ttggtggta  cggggtcgt  1860
gtggggcac  agctgactc  tgctttcga  gatcaaggc  gggagtatg  caaggatgg  1920
aacctccgg  cctggtgga  gaactcgtc  gtggaggca  tcaagcagc  gaccgagtg  1980
atggtacag  agtataaca  ctacagtgt  aacggagag  ccgtgaatg  gcggcacac  2040
ctcggggag  acatcgcgg  caacggggg  ctcaaggca  cctaccggg  gtaccagaa  2100
tgggtaaag  agaacggag  tgagcagat  ctgcccacc  tgggtctca  cagcaacca  2160
ctcttcttc  tgggattcg  acaggtctg  tgctcggtc  gcacaccag  gagctccca  2220
gaaggcctc  tcaccgatc  gcacagccc  tcccgcttc  gggtcatcg  ctcactctc  2280
aactccaag  agttctcag  acacttccg  tgcccgctc  gctccccca  gaaccctcg  2340
cacaaatgc  aagtctggt  agggctgaa  cgcagagaa  acaggtgga  gaagggaag  2400
ggcctgcag  cagctcccg  gaacagggc  gcgctgtca  cctccttcc  gcccctcgg  2460
cgagggccc  ttccccacc  tggagggta  gcagccatc  tgtctaagc  tatgccaga  2520
gctcagcac  ggaagccaa  atttgaccc  cttcgaagc  ccagcatcc  agacaccct  2580
gagtgatgc  ataccgggc  tttgggtgt  tcaagctgg  ggcttgcca  ccctgggcc  2640
cacactgac  atggcagtg  gacaggacc  tttgccacg  ccaatgcca  atataccac  2700
ataccactg  gtcaaatgc  ttaaagata  attttttgg  gagactatt  tttaagcat  2760
atggaatac  ctggaaatc  tcagggaaa  tgcatttaa  acacttttt  ttaaaaaaa  2820
attagtata  ttattatgt  ctctctttt  tttctaaac  acctgcgga  aaaggaaac  2880
ccactgatt  accccaggg  accccaggc  gttgagcag  ccaccagtt  gagcactgc  2940
ttagcccat  gttggtgta  ttgcttgtg  agtcaggag  tgtaggggc  aggcagaag  3000
ggtggccag  tgaagggcc  gatttatga  catggcctt  tctgtcctg  ctccggagt  3060
caaccatgg  aaccccaac  aggacgggc  gttacccaa  ttgatccct  tggcagtac  3120
aagccagag  aatggcctc  gtacaaccg  gggacccct  aacactctg  acaacatca  3180
aggagcccg  cggggctga  accccacac  ccatcagat  cacactatt  tccaaagat  3240
tcttgtttt  gtcccacct  ttctggcct  gggaccggt  gcctctctg  agcagttct  3300
acatcctga  gtggtcgcc  tctgtacca  gggaaaggg  aaagagaaa  cagtccagt  3360
ctccctcca  gctccgtag  ctgtagtta  cctggcttg  ctcctggga  cccttctct  3420
gtgccttac  ccaggccac  gcccctgag  ccctttgag  aggcagcat  tgtcttgct  3480
tctcagtgg  gcccccaag  gtcctgact  gaagccaac  ccatagccc  actcccaga  3540
gccccaggg  accgtccca  accctacag  acagccatt  cacacattc  ccaccccac  3600
cccctctgc  gcaggccaa  actggaagg  tcccagccc  atcgggctc  agggaatgg  3660
aggatgtca  ccacccaca  catcaccta  cagatatgt  ggcctccac  aagtggcgc  3720
cactgaggt  ttcatgact  ctgtaggga  caagctctt  tgacctgtg  gtgaggagc  3780
cagtagaag  gcccatcac  gcccctggc  agtcatgcc  ccacatagc  caacacaca  3840
acacactca  ctggaagcc  gagtcctcc  tggccaaga  gcagagaca  tgtagtctc  3900
gtcctgcta  cgtagcgat  gtcttagca  tgggatggg  agctgcaag  gggtgtctg  3960
caaggttct  ggtccctgt  aacacattc  aggtctcag  tcttcgggg  aaagtaaca  4020
aggaagcag  aaggtgctg  agccacgcc  tgccacaca  gggggacct  ctgggtggg  4080
tcatctgcc  tttctatcc  ctcgccctg  ttccccaca  gtggccgtc  tggatgcca  4140
tatctagaa  cagggtcct  agctggagt  agccatgca  gcattgctc  gggtgtgca  4200
ggagccaag  caggaaaac  caggctggt  agggatgga  gggtgcaaa  gcagcatcc  4260
gacccctgt  cctccagag  tttgagaag  gcagaatta  gaagggcac  cgccctcag  4320
aagagccct  ctctcaagc  cggagtttc  ctgcaggca  aaggacatg  ggtttggaa  4380
tggggactc  atttttttg  attattgtg  tttgtgcta  tgtagtttt  gtgtggcac  4440
tattataat  aaaataaag  acttatacc  4469



<210> 1914
<211> 762
<212> PRT
<213> Rattus norvegicus
<308> P42893
<400> 1914

Met Gly Ser Leu Arg Pro Pro Gln Gly Leu Gly Leu Gln Trp Ser Ser 
  1               5                  10                  15
Phe Phe Leu Gly Lys Lys Gly Pro Gly Leu Thr Val Ser Leu Pro Leu 
             20                  25                  30
Leu Ala Ser Ser Leu Gln Val Asn Phe Arg Ser Pro Arg Ser Gly Gln 
         35                  40                  45
Arg Cys Trp Ala Ala Arg Thr Ser Val Glu Lys Arg Leu Val Val Leu 
     50                  55                  60
Val Thr Leu Leu Ala Ala Gly Leu Val Ala Cys Leu Ala Ala Leu Gly 
 65                  70                  75                  80
Ile Gln Tyr Arg Thr Arg Thr Pro Pro Val Cys Leu Thr Glu Ala Cys 
                 85                  90                  95
Val Ser Val Thr Ser Ser Ile Leu Asn Ser Met Asp Pro Thr Val Asp 
             100                105                110
Pro Cys Gln Asp Phe Phe Ser Tyr Ala Cys Gly Gly Trp Ile Lys Ala 
         115                120                125
Asn Pro Val Pro Asp Gly His Ser Arg Trp Gly Thr Phe Ser Asn Leu 
     130                135                140
Trp Glu His Asn Gln Ala Ile Ile Lys His Leu Leu Glu Asn Ser Thr 
 145                150                155                160
Ala Ser Ala Ser Glu Ala Glu Lys Lys Ala Gln Val Tyr Tyr Arg Ala 
                 165                170                175
Cys Met Asn Glu Thr Arg Ile Glu Glu Leu Arg Ala Lys Pro Leu Met 
             180                185                190
Glu Leu Ile Glu Lys Leu Gly Gly Trp Asn Ile Thr Gly Pro Trp Ala 
         195                200                205
Lys Asp Asn Phe Gln Asp Thr Leu Gln Val Val Thr Ala His Tyr Arg 
     210                215                220
Thr Ser Pro Phe Phe Ser Val Tyr Val Ser Ala Asp Ser Lys Asn Ser 
 225                230                235                240
Asn Ser Asn Val Ile Gln Val Asp Gln Ser Gly Leu Gly Leu Pro Ser 
                 245                250                255
Arg Asp Tyr Tyr Leu Asn Lys Thr Glu Asn Glu Lys Val Leu Thr Gly 
             260                265                270
Tyr Leu Asn Tyr Met Val Gln Leu Gly Lys Leu Leu Gly Gly Gly Asp 
         275                280                285
Glu Asp Ser Ile Arg Pro Gln Met Gln Gln Ile Leu Asp Phe Glu Thr 
     290                295                300
Ala Leu Ala Asn Ile Thr Ile Pro Gln Glu Lys Arg Arg Asp Glu Glu 
 305                310                315                320
Leu Ile Tyr His Lys Val Thr Ala Ala Glu Leu Gln Thr Leu Ala Pro 
                 325                330                335
Ala Ile Asn Trp Leu Pro Phe Leu Asn Ala Ile Phe Tyr Pro Val Glu 
             340                345                350
Ile Asn Glu Ser Glu Pro Ile Val Val Tyr Asp Lys Glu Tyr Leu Arg 
         355                360                365
Gln Val Ser Thr Leu Ile Asn Ser Thr Asp Lys Cys Leu Leu Asn Asn 
     370                375                380
Tyr Met Met Trp Asn Leu Val Arg Lys Thr Ser Ser Phe Leu Asp Gln 
 385                390                395                400
Arg Phe Gln Asp Ala Asp Glu Lys Phe Met Glu Val Met Tyr Gly Thr 
                 405                410                415
Lys Lys Thr Cys Leu Pro Arg Trp Lys Phe Cys Val Ser Asp Thr Glu 
             420                425                430
Asn Asn Leu Gly Phe Ala Leu Gly Pro Met Phe Val Lys Ala Thr Phe 
         435                440                445
Ala Glu Asp Ser Lys Asn Ile Ala Ser Glu Ile Ile Leu Glu Ile Lys 
     450                455                460
Lys Ala Phe Glu Glu Ser Leu Ser Thr Leu Lys Trp Met Asp Glu Asp 
 465                470                475                480
Thr Arg Arg Ser Ala Lys Glu Lys Ala Asp Ala Ile Tyr Asn Met Ile 
                 485                490                495
Gly Tyr Pro Asn Phe Ile Met Asp Pro Lys Glu Leu Asp Lys Val Phe 
             500                505                510
Asn Asp Tyr Thr Ala Val Pro Asp Leu Tyr Phe Glu Asn Ala Met Arg 
         515                520                525
Phe Phe Asn Phe Ser Leu Arg Val Thr Ala Asp Gln Leu Arg Lys Ala 
     530                535                540
Pro Asn Arg Asp Gln Trp Ser Met Thr Pro Pro Met Val Asn Ala Tyr 
 545                550                555                560
Tyr Ser Pro Thr Lys Asn Glu Ile Val Phe Pro Ala Gly Ile Leu Gln 
                 565                570                575
Ala Pro Phe Tyr Thr Arg Ser Ser Pro Asn Ala Leu Asn Phe Gly Gly 
             580                585                590
Ile Gly Val Val Val Gly His Glu Leu Thr His Ala Phe Asp Asp Gln 
         595                600                605
Gly Arg Glu Tyr Asp Lys Asp Gly Asn Leu Arg Pro Trp Trp Lys Asn 
     610                615                620
Ser Ser Val Glu Ala Phe Lys Gln Gln Thr Glu Cys Met Val Gln Gln 
 625                630                635                640
Tyr Asn Asn Tyr Ser Val Asn Gly Glu Pro Val Asn Gly Arg His Thr 
                 645                650                655
Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Lys Ala Ala Tyr Arg 
             660                665                670
Ala Tyr Gln Asn Trp Val Lys Lys Asn Gly Ala Glu Gln Ile Leu Pro 
         675                680                685
Thr Leu Gly Leu Thr Ser Asn Gln Leu Phe Phe Leu Gly Phe Ala Gln 
     690                695                700
Val Trp Cys Ser Val Arg Thr Pro Glu Ser Ser His Glu Gly Leu Ile 
 705                710                715                720
Thr Asp Pro His Ser Pro Ser Arg Phe Arg Val Ile Gly Ser Leu Ser 
                 725                730                735
Asn Ser Lys Glu Phe Ser Glu His Phe Arg Cys Pro Leu Gly Ser Pro 
             740                745                750
Met Asn Pro Arg His Lys Cys Glu Val Trp 
         755                760



<210> 1915
<211> 2720
<212> DNA
<213> Homo sapiens
<308> Z35307
<400> 1915

cgccccccc  gtgtccgcc  tgctgtcgg  gctggggat  tcgacgtac  agcgggcca  60
gctggacga  gaggacctg  tggactcgc  ctccgaggg  gacgcatac  ccaacggcc  120
gcaggtgaa  ttccacagc  cccggagtg  ccagaggtg  tgggctgca  ggacccagg  180
ggagaagcg  ctggtggtg  tggtggtac  tctggcggc  ggactggtg  cctgcttgg  240
agcactggg  atccagtac  agacaagat  cccctctgt  tgcctgagc  aagcttgtg  300
ctcagtgac  agctccatc  tgagctcca  ggaccccac  gtggacccc  gccatgact  360
cttcagcta  gcctgtggg  gctggatca  ggccaaccc  gtccctgat  gccactcac  420
ctgggggac  ttcagcaac  tctgggaac  caaccaagc  atcatcaag  acctcctcg  480
aaactccac  gccagcgtg  gcgaggcag  gagaaaggc  caagtatac  accgtgcgt  540
catgaacga  accaggatc  aggagctca  ggccaaacc  ctaatggag  tgattgaga  600
gctcggggg  tggaacatc  caggtccct  ggccaagga  aacttccag  acaccctgc  660
ggtggtcac  gcccactac  gcacctcac  cttcttctc  gtctatgtc  gtgccgatt  720
caagaactc  aacagcaac  tgatccagg  ggaccagtc  ggcctgggc  tgccctcga  780
agactatta  ctgaacaaa  ctgaaaacg  gaaggtgct  accggatat  tgaactaca  840
ggtccagct  gggaagctg  tgggcggcg  ggacgagga  gccatccgg  cccagatgc  900
gcagatctt  gactttgag  cggcactgg  caacatcac  atcccacag  agaagcgcc  960
tgatgagga  ctcatctac  acaaagtga  ggcagccga  ctgcagacc  tggcacccg  1020
catcaactg  ttgcctttt  tcaacacca  cttctaccc  gtggagatc  atgaatccg  1080
gcctattgt  gtctatgac  aggaatacc  tgagcagat  tccactctc  tcaacacca  1140
cgacagatg  ctgctcaac  actacatga  ctggaacct  gtgcggaaa  caagctcct  1200
ccttgacca  cgctttcag  acgccgatg  gaagttcat  gaagtcatg  acgggacca  1260
gaagacctg  cttcctcgc  ggaagtttt  cgtgagtga  acagaaaac  acctgggct  1320
tgcgttggg  cccatgttt  tcaaagcaa  cttcgccga  gacagcaag  gcatagcca  1380
cgagatcat  ctggagatt  agaaggcat  tgaggaaag  ctgagcacc  tgaagtgga  1440
ggatgagga  acccgaaaa  cagccaagg  aaaggccga  gccatctac  acatgatag  1500
ataccccaa  ttcatcatg  atcccaagg  gctggacaa  gtgtttaat  actacactg  1560
agttccaga  ctctacttt  aaaatgcca  gcggttttt  aacttctca  ggagggtca  1620
tgccgatca  ctcaggaaa  cccccaaca  agatcagtg  agcatgacc  cgcccatgg  1680
gaacgccta  tactcgccc  ccaagaatg  gattgtgtt  ccggccggg  tcctgcagg  1740
accattcta  acacgctcc  cacccaagg  cttaaactt  ggtggcata  gtgtcgtcg  1800
gggccatga  ctgactcat  cttttgatg  tcaaggacg  gagtatgac  aggacggga  1860
cctccggcc  tggtggaag  actcatccg  ggaggcctt  aagcgtcag  ccgagtgca  1920
ggtagagca  tacagcaac  acagcgtga  cggggagcc  gtgaacggg  ggcacaccc  1980
gggggagaa  atcgccgac  acgggggtc  caaggcggc  tatcgggct  accagaact  2040
ggtgaagaa  aacggggct  agcactcgc  ccccaccct  ggcctcacc  ataaccagc  2100
cttcttcct  ggctttgca  aggtctggt  ctccgtccg  acacctgag  gctcccacg  2160
aggcctcat  accgatccc  acagcccct  tcgcttccg  gtcatcggc  ccctctcca  2220
ttccaagga  ttctcagaa  acttccgct  cccacctgg  tcacccatg  acccgcctc  2280
caagtgcga  gtctggtaa  gacgaagcg  agagagcca  gacggagga  gggaagggg  2340
tgaggacga  acccccatc  agcctccag  gcattgctc  gcccgcttg  ccacccggg  2400
ccctgcttc  tcacactgg  gggttttca  ccggaaccg  gcccatggt  ttggctctc  2460
acgtgaccc  cagtctgat  ccctgtgaa  agccggaca  cccaggcac  cgtgtgcgc  2520
accttcagc  ggcattcgg  tgctgggct  gtggctcat  aggcctggg  cccacactg  2580
caagcgcca  atacgccac  aataccact  tgtcaaatg  tttcaagat  tatttttgg  2640
gaaactatt  tttaaacac  gtggaatac  ctggaaatc  tcagggaaa  acacattta  2700
acacttttt  ttttaagccc  2720



<210> 1916
<211> 770
<212> PRT
<213> Homo sapiens
<308> P42892
<400> 1916

Met Arg Gly Val Trp Pro Pro Pro Val Ser Ala Leu Leu Ser Ala Leu 
  1               5                  10                  15
Gly Met Ser Thr Tyr Lys Arg Ala Thr Leu Asp Glu Glu Asp Leu Val 
             20                  25                  30
Asp Ser Leu Ser Glu Gly Asp Ala Tyr Pro Asn Gly Leu Gln Val Asn 
         35                  40                  45
Phe His Ser Pro Arg Ser Gly Gln Arg Cys Trp Ala Ala Arg Thr Gln 
     50                  55                  60
Val Glu Lys Arg Leu Val Val Leu Val Val Leu Leu Ala Ala Gly Leu 
 65                  70                  75                  80
Val Ala Cys Leu Ala Ala Leu Gly Ile Gln Tyr Gln Thr Arg Ser Pro 
                 85                  90                  95
Ser Val Cys Leu Ser Glu Ala Cys Val Ser Val Thr Ser Ser Ile Leu 
             100                105                110
Ser Ser Met Asp Pro Thr Val Asp Pro Cys His Asp Phe Phe Ser Tyr 
         115                120                125
Ala Cys Gly Gly Trp Ile Lys Ala Asn Pro Val Pro Asp Gly His Ser 
     130                135                140
Arg Trp Gly Thr Phe Ser Asn Leu Trp Glu His Asn Gln Ala Ile Ile 
 145                150                155                160
Lys His Leu Leu Glu Asn Ser Thr Ala Ser Val Ser Glu Ala Glu Arg 
                 165                170                175
Lys Ala Gln Val Tyr Tyr Arg Ala Cys Met Asn Glu Thr Arg Ile Glu 
             180                185                190
Glu Leu Arg Ala Lys Pro Leu Met Glu Leu Ile Glu Arg Leu Gly Gly 
         195                200                205
Trp Asn Ile Thr Gly Pro Trp Ala Lys Asp Asn Phe Gln Asp Thr Leu 
     210                215                220
Gln Val Val Thr Ala His Tyr Arg Thr Ser Pro Phe Phe Ser Val Tyr 
 225                230                235                240
Val Ser Ala Asp Ser Lys Asn Ser Asn Ser Asn Val Ile Gln Val Asp 
                 245                250                255
Gln Ser Gly Leu Gly Leu Pro Ser Arg Asp Tyr Tyr Leu Asn Lys Thr 
             260                265                270
Glu Asn Glu Lys Val Leu Thr Gly Tyr Leu Asn Tyr Met Val Gln Leu 
         275                280                285
Gly Lys Leu Leu Gly Gly Gly Asp Glu Glu Ala Ile Arg Pro Gln Met 
     290                295                300
Gln Gln Ile Leu Asp Phe Glu Thr Ala Leu Ala Asn Ile Thr Ile Pro 
 305                310                315                320
Gln Glu Lys Arg Arg Asp Glu Glu Leu Ile Tyr His Lys Val Thr Ala 
                 325                330                335
Ala Glu Leu Gln Thr Leu Ala Pro Ala Ile Asn Trp Leu Pro Phe Leu 
             340                345                350
Asn Thr Ile Phe Tyr Pro Val Glu Ile Asn Glu Ser Glu Pro Ile Val 
         355                360                365
Val Tyr Asp Lys Glu Tyr Leu Glu Gln Ile Ser Thr Leu Ile Asn Thr 
     370                375                380
Thr Asp Arg Cys Leu Leu Asn Asn Tyr Met Ile Trp Asn Leu Val Arg 
 385                390                395                400
Lys Thr Ser Ser Phe Leu Asp Gln Arg Phe Gln Asp Ala Asp Glu Lys 
                 405                410                415
Phe Met Glu Val Met Tyr Gly Thr Lys Lys Thr Cys Leu Pro Arg Trp 
             420                425                430
Lys Phe Cys Val Ser Asp Thr Glu Asn Asn Leu Gly Phe Ala Leu Gly 
         435                440                445
Pro Met Phe Val Lys Ala Thr Phe Ala Glu Asp Ser Lys Ser Ile Ala 
     450                455                460
Thr Glu Ile Ile Leu Glu Ile Lys Lys Ala Phe Glu Glu Ser Leu Ser 
 465                470                475                480
Thr Leu Lys Trp Met Asp Glu Glu Thr Arg Lys Ser Ala Lys Glu Lys 
                 485                490                495
Ala Asp Ala Ile Tyr Asn Met Ile Gly Tyr Pro Asn Phe Ile Met Asp 
             500                505                510
Pro Lys Glu Leu Asp Lys Val Phe Asn Asp Tyr Thr Ala Val Pro Asp 
         515                520                525
Leu Tyr Phe Glu Asn Ala Met Arg Phe Phe Asn Phe Ser Trp Arg Val 
     530                535                540
Thr Ala Asp Gln Leu Arg Lys Ala Pro Asn Arg Asp Gln Trp Ser Met 
 545                550                555                560
Thr Pro Pro Met Val Asn Ala Tyr Tyr Ser Pro Thr Lys Asn Glu Ile 
                 565                570                575
Val Phe Pro Ala Gly Ile Leu Gln Ala Pro Phe Tyr Thr Arg Ser Ser 
             580                585                590
Pro Lys Ala Leu Asn Phe Gly Gly Ile Gly Val Val Val Gly His Glu 
         595                600                605
Leu Thr His Ala Phe Asp Asp Gln Gly Arg Glu Tyr Asp Lys Asp Gly 
     610                615                620
Asn Leu Arg Pro Trp Trp Lys Asn Ser Ser Val Glu Ala Phe Lys Arg 
 625                630                635                640
Gln Thr Glu Cys Met Val Glu Gln Tyr Ser Asn Tyr Ser Val Asn Gly 
                 645                650                655
Glu Pro Val Asn Gly Arg His Thr Leu Gly Glu Asn Ile Ala Asp Asn 
             660                665                670
Gly Gly Leu Lys Ala Ala Tyr Arg Ala Tyr Gln Asn Trp Val Lys Lys 
         675                680                685
Asn Gly Ala Glu His Ser Leu Pro Thr Leu Gly Leu Thr Asn Asn Gln 
     690                695                700
Leu Phe Phe Leu Gly Phe Ala Gln Val Trp Cys Ser Val Arg Thr Pro 
 705                710                715                720
Glu Ser Ser His Glu Gly Leu Ile Thr Asp Pro His Ser Pro Ser Arg 
                 725                730                735
Phe Arg Val Ile Gly Ser Leu Ser Asn Ser Lys Glu Phe Ser Glu His 
             740                745                750
Phe Arg Cys Pro Pro Gly Ser Pro Met Asn Pro Pro His Lys Cys Glu 
         755                760                765
Val Trp 
     770



<210> 1917
<211> 3335
<212> DNA
<213> Rattus norvegicus
<308> D29766
<400> 1917

gtacgcggg  agcacggcc  ctggccgtg  agcaccatg  agtacctgg  gagtgtggg  60
gcggggccg  ccaggcggg  gggcggtct  gaggacgtt  cctgggggc  ccgagtgtc  120
cgccggccg  agagttacc  ggcagctcg  cacgtaaac  agtccctcc  tcggtccgc  180
tttcgagtc  ccgcagctc  cggagctag  gtgacgccc  ccgcagccc  tgggtccgg  240
ttgcctgag  ctcagcccg  ggcggtatg  agagggact  agaaaccga  atttgctga  300
ggctgcaaa  cggcggcga  ccgcgacaa  aacgtgctg  ccaaagccc  ctatgacaa  360
gtagctgag  ctccggatg  actctcctt  cgaaagggt  acatcatga  agtgctcga  420
cgggacact  agggcctgg  tggctggtg  ctctgctca  tgcatgggc  ccagggcat  480
gtgcctggt  accgcctca  gattctggt  ggcatgtat  acaagaagc  agcagcacc  540
ggaccaggc  cacctgcca  cccacccca  ccccagccc  gccttcccc  gggcgtcca  600
actccagtg  ctccagctt  ccagtacag  cccatgctc  ccactgcat  ccaacccca  660
cctgacaat  tgtacctgg  acccactcc  agcaagact  agcaaggtc  ctaccaagc  720
cctgggccc  acccacagt  ccagtcacc  ccagccaaa  aaacatcca  attctcaaa  780
caaacacct  atcactcat  tcccagccc  gccacagac  tttaccagg  gcctccagg  840
cctggaagt  cagcccagg  catttacca  gtgccacct  ccgctggca  agggcatga  900
atctaccaa  tccctccat  tttggacac  cgcagctgg  agggaacga  gccaccggc  960
aaggtggtg  tacctactc  agtgggaca  ggctatgtg  acgaggcct  ccaggcaga  1020
caggatgag  acgacaccc  gcgccacct  ctagctcca  gttcccagg  catctatga  1080
gtgccccct  ttcgaggac  gcttcccaa  cagtatggc  aggaggtat  tgacacccc  1140
cctatggca  tcaaaggcc  caatggccg  gacccgttg  tggatgtgt  tgacgtgcc  1200
cctagtgtg  agaaaggcc  gccgccgtc  aaccatcat  cggtgtatg  tgttcctcc  1260
tctgtgagc  aggatgtgc  tgatggccc  ctgctgcgt  aggaaacat  tgatgtacc  1320
cctgccttc  ccaaaccca  gccttttga  ccgacccga  atccattaa  cctcgctgc  1380
cctcctccg  actccccac  agctgagga  gtgtatgat  tgccacccc  tgctcctga  1440
ctctatgat  tgccccctg  tttgcggcg  cctggccct  gaacactgt  tgacgtgcc  1500
cgagagcgg  tgctccctc  tgaggtggc  gatgggagt  taattgatg  tggtgtgta  1560
gctgtgccc  caccagccg  gcgagaggc  ccaacagat  gcaagcgcc  gtcggcctc  1620
agcacgggc  gcacacgca  cagccaatc  gcgtcttcc  tggaggtag  ggtgccagg  1680
cgggagccc  tggagctgg  agttgctgt  gagaccctg  ctcggctac  gcagggtgt  1740
agcaccacc  tagcccacc  tctggacct  gtgggcagt  ccagtggcc  cgggggctg  1800
cgtagtacc  ctgagcccc  ggagcctcc  gtgcaggac  tgaaagctg  agtggccgc  1860
gttcatggg  cagtacatg  gctcctgga  tttgcccgc  gtgcagtga  cagtgccac  1920
cacacttct  accgcactt  gcacgccaa  cttagccgg  agctacaga  gatggagga  1980
gtgtaccag  cactggtgg  ccatggtca  gtccttgac  gtggccggg  aggtccagg  2040
ttcactctg  acgacctgg  ccgcctggt  gcctgctca  gggctgtgc  cgaggatgc  2100
aagcagctg  cctcctttt  gcatggtaa  gcctcgctg  ttttcagac  gaccaaagc  2160
cctggcccc  ggcctgagg  cagcagctc  ctgcacctc  accccaccg  taaagccag  2220
agcatccag  cacgccctc  accctcacc  ccaaagttc  cctcccagg  ctctccgga  2280
ggccagtat  agaacagtg  agggggttg  atggaggac  atgactacg  tcatctgca  2340
gggaaggag  aatttgaga  gacccagaa  gaactgctg  aaaagggca  catcgtgcg  2400
cagggaaaa  gccaactgg  gctgcagca  ctgaaacag  ttgagcgac  ggagcagga  2460
gtgtctcgt  ccatagacc  tgacctggc  aactggaca  cagcccagc  ccttgtgcc  2520
gggcggaca  ggggactgg  gccttcaga  cgacagctg  tgctcttct  cttggagca  2580
tgtgaggcc  acctgacca  actgacaga  gcggtggac  ccttcttca  cgcagtggc  2640
accaaccag  cacccaaga  ctttgtggc  cacagcaag  ttgtcattc  tagtgcaca  2700
aagcttgtg  tcattgggg  cacactgtc  cggcaggca  aggcagctg  tgtgcgaag  2760
aaagtgacc  actacagca  tctgctgtg  gacctcctg  gtggcatcg  ggccaccac  2820
aaggccgct  ccctgcagt  cccatcccc  tctgctgcc  aggacatgg  agacagggt  2880
aaggagcta  gccacagca  tcagcagtt  cgccgtgtc  tgggccagc  ggctgccgc  2940
tgaaagcag  agactgggc  gtgaggctg  ggagtgggt  gcggtggtg  gagctaccc  3000
ggcgctcgt  ttgaagtgg  gatcctgca  gtttgggga  aggtaaccc  agctctgct  3060
tgggcctgg  gccctcaac  gtccaggga  ttgtacata  ttatatcaa  gcaggatgc  3120
gaatgcctc  tcggagagg  tgaggagcc  cgtcagagt  gaccatggg  tgggatcac  3180
agggttggg  cacatgggc  ccagtccac  gggctccct  ggacaggaa  tacagtgtg  3240
tgtacacct  tgcaccaag  aaacctaaa  aactatttt  cactattga  ttttttcca  3300
tcatttgac  aatagtcta  atttaataa  atttt  3335



<210> 1918
<211> 968
<212> PRT
<213> Rattus norvegicus
<308> Q63767
<400> 1918

Met Lys Tyr Leu Val Ser Val Gly Ala Gly Pro Ala Arg Arg Ala Gly 
  1               5                  10                  15
Gly Leu Glu Asp Val Ser Trp Gly Pro Arg Val Ser Arg Arg Pro Gln 
             20                  25                  30
Ser Tyr Arg Ala Ala Arg His Val Asn Glu Ser Leu Pro Arg Ser Ala 
         35                  40                  45
Phe Arg Val Pro Ala Ala His Gly Ala Ser Val Thr Pro Ser Ala Ala 
     50                  55                  60
Leu Gly Ser Gly Leu Pro Glu Thr Gln Pro Glu Ala Val Cys Arg Gly 
 65                  70                  75                  80
Thr Glu Lys Pro Arg Phe Ala Glu Gly Cys Lys Pro Ala Ala Ser Arg 
                 85                  90                  95
Asp Lys Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala Glu Ser 
             100                105                110
Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr Val Leu Glu 
         115                120                125
Arg Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu His Gly 
     130                135                140
Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val Gly Met 
 145                150                155                160
Tyr Asp Lys Lys Pro Ala Ala Pro Gly Pro Gly Pro Pro Ala Thr Pro 
                 165                170                175
Pro Gln Pro Gln Pro Ser Leu Pro Gln Gly Val His Thr Pro Val Pro 
             180                185                190
Pro Ala Ser Gln Tyr Ser Pro Met Leu Pro Thr Ala Tyr Gln Pro Gln 
         195                200                205
Pro Asp Asn Val Tyr Leu Val Pro Thr Pro Ser Lys Thr Gln Gln Gly 
     210                215                220
Leu Tyr Gln Ala Pro Gly Pro Asn Pro Gln Phe Gln Ser Pro Pro Ala 
 225                230                235                240
Lys Gln Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Ser Phe Pro 
                 245                250                255
Ser Pro Ala Thr Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Ser Pro 
             260                265                270
Ala Gln Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Thr Gly His Asp 
         275                280                285
Ile Tyr Gln Val Pro Pro Ser Leu Asp Thr Arg Ser Trp Glu Gly Thr 
     290                295                300
Lys Pro Pro Ala Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr 
 305                310                315                320
Val Tyr Glu Ala Ser Gln Ala Glu Gln Asp Glu Tyr Asp Thr Pro Arg 
                 325                330                335
His Leu Leu Ala Pro Gly Ser Gln Asp Ile Tyr Asp Val Pro Pro Val 
             340                345                350
Arg Gly Leu Leu Pro Asn Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro 
         355                360                365
Pro Met Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Asp Val 
     370                375                380
Tyr Asp Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His 
 385                390                395                400
His Ser Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp 
                 405                410                415
Gly Pro Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala 
             420                425                430
Lys Pro Lys Pro Phe Asp Pro Thr Arg His Pro Leu Ile Leu Ala Ala 
         435                440                445
Pro Pro Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro 
     450                455                460
Pro Ala Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly 
 465                470                475                480
Pro Gly Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu 
                 485                490                495
Val Ala Asp Gly Ser Val Ile Asp Asp Gly Val Tyr Ala Val Pro Pro 
             500                505                510
Pro Ala Glu Arg Glu Ala Pro Thr Asp Gly Lys Arg Leu Ser Ala Ser 
         515                520                525
Ser Thr Gly Ser Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val 
     530                535                540
Val Val Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Thr 
 545                550                555                560
Leu Ala Arg Leu Gln Gln Gly Val Ser Thr Thr Val Ala His Leu Leu 
                 565                570                575
Asp Leu Val Gly Ser Ala Ser Gly Pro Gly Gly Trp Arg Ser Thr Ser 
             580                585                590
Glu Pro Gln Glu Pro Pro Val Gln Asp Leu Lys Ala Ala Val Ala Ala 
         595                600                605
Val His Gly Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val 
     610                615                620
Ser Ser Ala Thr His Thr Ser Asp Arg Thr Leu His Ala Lys Leu Ser 
 625                630                635                640
Arg Gln Leu Gln Lys Met Glu Asp Val Tyr Gln Thr Leu Val Val His 
                 645                650                655
Gly Gln Val Leu Asp Ser Gly Arg Gly Gly Pro Gly Phe Thr Leu Asp 
             660                665                670
Asp Leu Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala 
         675                680                685
Lys Gln Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg 
     690                695                700
Arg Thr Lys Ala Pro Gly Pro Gly Pro Glu Gly Ser Ser Ser Leu His 
 705                710                715                720
Leu Asn Pro Thr Asp Lys Ala Ser Ser Ile Gln Ser Arg Pro Leu Pro 
                 725                730                735
Ser Pro Pro Lys Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu 
             740                745                750
Asn Ser Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln 
         755                760                765
Gly Lys Glu Glu Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly 
     770                775                780
Asn Ile Val Arg Gln Gly Lys Gly Gln Leu Glu Leu Gln Gln Leu Lys 
 785                790                795                800
Gln Phe Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp 
                 805                810                815
Leu Ala Asn Trp Thr Pro Ala Gln Pro Leu Val Pro Gly Arg Thr Gly 
             820                825                830
Gly Leu Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln 
         835                840                845
Cys Glu Ala Asn Leu Thr Thr Leu Thr Asp Ala Val Asp Ala Phe Phe 
     850                855                860
Thr Ala Val Ala Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser 
 865                870                875                880
Lys Phe Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr 
                 885                890                895
Leu Ser Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Lys Val Thr His 
             900                905                910
Tyr Ser Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr 
         915                920                925
Lys Ala Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met 
     930                935                940
Val Asp Arg Val Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg 
 945                950                955                960
Val Leu Gly Gln Leu Ala Ala Ala 
                 965



<210> 1919
<211> 3208
<212> DNA
<213> Homo sapiens
<308> AJ242987
<400> 1919

gaggcggca  ctgcgcggc  gcaccgggg  ggctgcggc  cgctcggag  cccgaggca  60
gcggcccgg  cagctcggt  tgcgccccc  cgagagccg  gccccaggc  cgccggaca  120
catgaacca  ctgaacgtg  tggccaaag  gctctatga  aatgtggcc  agtccccgg  180
tgagctctc  ttccgcaag  gtgacatca  gacggtgct  gagcaggac  cgcagggcc  240
ggacggctg  tggctctgc  cgctgcatg  gcgccaggg  atcgtgcct  ggaaccgcc  300
caagatctt  gtgggcatg  atgataaga  gccagcagg  cctggctcc  gccctcccg  360
caccccggc  cagcctcag  ctggcctcc  tgccccagc  cctccggcc  cccagtaca  420
gcccatgct  cccaacacc  accagcccc  gccagacag  gtctacctg  tgcccactc  480
cagcaaggc  cagcaaggc  tctaccaag  cccgggtcc  agccctcag  tccagtctc  540
cccagccaa  cagacatcc  ccttctcga  gcagacacc  catcacccg  ttcccagcc  600
ggccacaga  ctgtaccag  tgcccccag  gcctggagg  cctgcccag  atatttacc  660
ggtgccacc  tctgccggg  tggggcatg  catctacca  gtccccccg  ccatggaca  720
acgcagctg  gagggcacg  agcccccgg  aaaggtggt  gtgcccacc  gcgtggggc  780
gggctatgt  tacgaggcc  cccagccgg  gcaggacga  tacgacatc  cgcgacacc  840
gctggcccc  gggccacag  acatctatg  tgtgccccc  gttcggggg  tgcttccca  900
ccagtatgg  caggaggtg  atgacacac  ccccatggc  gtcaagggt  ccaatggcc  960
agacccgtt  ctggaggtg  atgacgtgc  ccccagtgt  gagaagggc  tgccaccgt  1020
caaccacca  gcagtctac  acgttcctc  atcggtgag  aaggatgtg  ccgatggcc  1080
actgctgcg  gaggagacc  acgatgtgc  ccccgcctt  gccaaggcc  agccctttg  1140
cccggcccg  accccactg  tactggctg  gccccctcc  gactccccg  cggccgagg  1200
cgtgtatga  gtgccgccc  cggctcctg  cctctacga  gtgccccct  gcttgcggc  1260
gcctggccc  ggcaccctg  acgatgtgc  ccgtgaacg  gtgcttcct  ctgaggtgg  1320
tgatggtgg  gtggtcgac  gtggtgtgt  tgcggtgcc  cccccagct  aacgtgaag  1380
cccggcaga  ggcaagcgc  tgtcggcct  cagcaccgg  agcacacgc  gcagccagt  1440
tgcgtcctc  ttggaggtg  cagggccgg  ccgggaacc  ctggagctg  aagttgctg  1500
ggaggccct  gcacggctg  agcagggtg  gagcgccac  gttgcccac  ttctggacc  1560
ggcaggcag  gccggtgcg  ctgggagct  gcgtagccc  tctgagcca  aggagccgc  1620
ggtgcagga  ctgcaggct  ctgtggccg  tgtccagag  gccgtccac  agctgttgg  1680
gtttgcccg  agcgcggtg  gcaatgctg  ccacacatc  gaccgtgcc  tgcatgcca  1740
gcttagccg  cagctgcag  agatggagg  cgtgcacca  acgctggtg  cacatggtc  1800
ggccctcga  gctggccgg  gaggctctg  agccaccct  gaggacctg  accggctgg  1860
ggcctgctc  cgggctgtg  ccgaggacg  caagcagct  gcctccttc  tgcacggca  1920
tgcctcact  ctcttcaga  ggaccaagg  cactgcccc  gggcctgag  ggggtggca  1980
cctgcaccc  aaccccact  acaagacca  cagcatcca  tcacgaccc  tgccctcac  2040
ccctaagtt  acctcccag  actcaccag  tgggcagta  gagaacagc  aggggggct  2100
gatggagga  tatgactac  tccacctac  ggggaagga  gagtttgag  agacccaga  2160
ggagctgct  gaaaagggc  gcatcacgc  gcagggcaa  agccagctg  agttgcagc  2220
gctgaagca  tttgaacga  tggaacagg  ggtgtcacg  cccatagac  acgacctgg  2280
caactggac  ccagcccaa  ccctggccc  ggggcgaac  ggcggcctg  ggccctcgg  2340
ccggcagct  ctgctcttc  acctggagc  gtgtgaggc  aacctgacc  cactgacca  2400
cgccgtgga  gccttcttt  ccgccgtgg  caccaacca  ccgcccaag  tctttgtgg  2460
gcacagcaa  ttcgtcatc  tcagcgccc  caagctggt  ttcatcggg  acacactgt  2520
acggcaggc  aaggctgct  acgtgcgca  ccaggtgac  cactacagc  acctgctgt  2580
cgacctcct  cgcggcatc  tggccacca  caaggccgc  gccttgcag  acccatcgc  2640
ttccgcggc  caggacatg  tggagaggg  caaggagct  ggccacagc  cccagcagt  2700
ccgccgcgt  ctaggccag  tggcagccg  ctgagggtg  tgaccccag  agggaggca  2760
gggaggggt  cggcggtcc  agctccctg  ctcccatgt  aagagtcgc  gtgccacag  2820
cttagggac  ggaccccag  tctgcgtcg  tcctggtgc  ctggatgcc  aggaatctg  2880
atatattta  ggccgggca  ggtgtgggg  catgcctcc  caggagccg  agcccaggg  2940
ccgcagtgg  cttccccag  atgcaccac  ggcccgggt  gggtcacca  acggggctg  3000
agtgtgagg  tcctgcagc  tgcaggacc  cgtgccacc  cgagggctg  gcctggtcc  3060
acgagggtg  cgtgtcccc  gacagggcc  gtgcagttt  gtgtgtcct  cgccttacc  3120
ggagaagaa  ctgaagaac  atttttcgt  attggtttt  caatcattt  actaagagt  3180
tccatttaa  taaagtttt  aaaaggaa  3208



<210> 1920
<211> 870
<212> PRT
<213> Homo sapiens
<308> P56945
<400> 1920

Met Asn His Leu Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala 
  1               5                  10                  15
Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr Val 
             20                  25                  30
Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu 
         35                  40                  45
His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val 
     50                  55                  60
Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Ser Gly Pro Pro Ala 
 65                  70                  75                  80
Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala 
                 85                  90                  95
Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro Gln Pro Asp 
             100                105                110
Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln Gly Leu Tyr 
         115                120                125
Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln 
     130                135                140
Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Pro Phe Pro Ser Pro 
 145                150                155                160
Ala Thr Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln 
                 165                170                175
Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr 
             180                185                190
Gln Val Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr Lys Pro 
         195                200                205
Pro Ala Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr Val Tyr 
     210                215                220
Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu 
 225                230                235                240
Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly 
                 245                250                255
Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro Pro Met 
             260                265                270
Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp 
         275                280                285
Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala 
     290                295                300
Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro 
 305                310                315                320
Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala 
                 325                330                335
Lys Pro Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Ala Ala Pro Pro 
             340                345                350
Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala 
         355                360                365
Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly 
     370                375                380
Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala 
 385                390                395                400
Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala 
                 405                410                415
Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Thr 
             420                425                430
Gly Ser Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly 
         435                440                445
Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala 
     450                455                460
Arg Leu Gln Gln Gly Val Ser Ala Thr Val Ala His Leu Leu Asp Leu 
 465                470                475                480
Ala Gly Ser Ala Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser Glu Pro 
                 485                490                495
Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln 
             500                505                510
Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn 
         515                520                525
Ala Ala His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln 
     530                535                540
Leu Gln Lys Met Glu Asp Val His Gln Thr Leu Val Ala His Gly Gln 
 545                550                555                560
Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu Asp Leu 
                 565                570                575
Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln 
             580                585                590
Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Thr 
         595                600                605
Lys Ala Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His Pro Asn 
     610                615                620
Pro Thr Asp Lys Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro 
 625                630                635                640
Pro Lys Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser 
                 645                650                655
Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys 
             660                665                670
Glu Glu Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile 
         675                680                685
Thr Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe 
     690                695                700
Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala 
 705                710                715                720
Asn Trp Thr Pro Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly Gly Leu 
                 725                730                735
Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu 
             740                745                750
Ala Asn Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe Thr Ala 
         755                760                765
Val Ala Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe 
     770                775                780
Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Ser 
 785                790                795                800
Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Thr His Tyr Ser 
                 805                810                815
Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr Lys Ala 
             820                825                830
Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu 
         835                840                845
Arg Val Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg Val Leu 
     850                855                860
Gly Gln Leu Ala Ala Ala 
 865                870



<210> 1921
<211> 3335
<212> DNA
<213> Rattus norvegicus
<308> D29766
<400> 1921

gtacgcggg  agcacggcc  ctggccgtg  agcaccatg  agtacctgg  gagtgtggg  60
gcggggccg  ccaggcggg  gggcggtct  gaggacgtt  cctgggggc  ccgagtgtc  120
cgccggccg  agagttacc  ggcagctcg  cacgtaaac  agtccctcc  tcggtccgc  180
tttcgagtc  ccgcagctc  cggagctag  gtgacgccc  ccgcagccc  tgggtccgg  240
ttgcctgag  ctcagcccg  ggcggtatg  agagggact  agaaaccga  atttgctga  300
ggctgcaaa  cggcggcga  ccgcgacaa  aacgtgctg  ccaaagccc  ctatgacaa  360
gtagctgag  ctccggatg  actctcctt  cgaaagggt  acatcatga  agtgctcga  420
cgggacact  agggcctgg  tggctggtg  ctctgctca  tgcatgggc  ccagggcat  480
gtgcctggt  accgcctca  gattctggt  ggcatgtat  acaagaagc  agcagcacc  540
ggaccaggc  cacctgcca  cccacccca  ccccagccc  gccttcccc  gggcgtcca  600
actccagtg  ctccagctt  ccagtacag  cccatgctc  ccactgcat  ccaacccca  660
cctgacaat  tgtacctgg  acccactcc  agcaagact  agcaaggtc  ctaccaagc  720
cctgggccc  acccacagt  ccagtcacc  ccagccaaa  aaacatcca  attctcaaa  780
caaacacct  atcactcat  tcccagccc  gccacagac  tttaccagg  gcctccagg  840
cctggaagt  cagcccagg  catttacca  gtgccacct  ccgctggca  agggcatga  900
atctaccaa  tccctccat  tttggacac  cgcagctgg  agggaacga  gccaccggc  960
aaggtggtg  tacctactc  agtgggaca  ggctatgtg  acgaggcct  ccaggcaga  1020
caggatgag  acgacaccc  gcgccacct  ctagctcca  gttcccagg  catctatga  1080
gtgccccct  ttcgaggac  gcttcccaa  cagtatggc  aggaggtat  tgacacccc  1140
cctatggca  tcaaaggcc  caatggccg  gacccgttg  tggatgtgt  tgacgtgcc  1200
cctagtgtg  agaaaggcc  gccgccgtc  aaccatcat  cggtgtatg  tgttcctcc  1260
tctgtgagc  aggatgtgc  tgatggccc  ctgctgcgt  aggaaacat  tgatgtacc  1320
cctgccttc  ccaaaccca  gccttttga  ccgacccga  atccattaa  cctcgctgc  1380
cctcctccg  actccccac  agctgagga  gtgtatgat  tgccacccc  tgctcctga  1440
ctctatgat  tgccccctg  tttgcggcg  cctggccct  gaacactgt  tgacgtgcc  1500
cgagagcgg  tgctccctc  tgaggtggc  gatgggagt  taattgatg  tggtgtgta  1560
gctgtgccc  caccagccg  gcgagaggc  ccaacagat  gcaagcgcc  gtcggcctc  1620
agcacgggc  gcacacgca  cagccaatc  gcgtcttcc  tggaggtag  ggtgccagg  1680
cgggagccc  tggagctgg  agttgctgt  gagaccctg  ctcggctac  gcagggtgt  1740
agcaccacc  tagcccacc  tctggacct  gtgggcagt  ccagtggcc  cgggggctg  1800
cgtagtacc  ctgagcccc  ggagcctcc  gtgcaggac  tgaaagctg  agtggccgc  1860
gttcatggg  cagtacatg  gctcctgga  tttgcccgc  gtgcagtga  cagtgccac  1920
cacacttct  accgcactt  gcacgccaa  cttagccgg  agctacaga  gatggagga  1980
gtgtaccag  cactggtgg  ccatggtca  gtccttgac  gtggccggg  aggtccagg  2040
ttcactctg  acgacctgg  ccgcctggt  gcctgctca  gggctgtgc  cgaggatgc  2100
aagcagctg  cctcctttt  gcatggtaa  gcctcgctg  ttttcagac  gaccaaagc  2160
cctggcccc  ggcctgagg  cagcagctc  ctgcacctc  accccaccg  taaagccag  2220
agcatccag  cacgccctc  accctcacc  ccaaagttc  cctcccagg  ctctccgga  2280
ggccagtat  agaacagtg  agggggttg  atggaggac  atgactacg  tcatctgca  2340
gggaaggag  aatttgaga  gacccagaa  gaactgctg  aaaagggca  catcgtgcg  2400
cagggaaaa  gccaactgg  gctgcagca  ctgaaacag  ttgagcgac  ggagcagga  2460
gtgtctcgt  ccatagacc  tgacctggc  aactggaca  cagcccagc  ccttgtgcc  2520
gggcggaca  ggggactgg  gccttcaga  cgacagctg  tgctcttct  cttggagca  2580
tgtgaggcc  acctgacca  actgacaga  gcggtggac  ccttcttca  cgcagtggc  2640
accaaccag  cacccaaga  ctttgtggc  cacagcaag  ttgtcattc  tagtgcaca  2700
aagcttgtg  tcattgggg  cacactgtc  cggcaggca  aggcagctg  tgtgcgaag  2760
aaagtgacc  actacagca  tctgctgtg  gacctcctg  gtggcatcg  ggccaccac  2820
aaggccgct  ccctgcagt  cccatcccc  tctgctgcc  aggacatgg  agacagggt  2880
aaggagcta  gccacagca  tcagcagtt  cgccgtgtc  tgggccagc  ggctgccgc  2940
tgaaagcag  agactgggc  gtgaggctg  ggagtgggt  gcggtggtg  gagctaccc  3000
ggcgctcgt  ttgaagtgg  gatcctgca  gtttgggga  aggtaaccc  agctctgct  3060
tgggcctgg  gccctcaac  gtccaggga  ttgtacata  ttatatcaa  gcaggatgc  3120
gaatgcctc  tcggagagg  tgaggagcc  cgtcagagt  gaccatggg  tgggatcac  3180
agggttggg  cacatgggc  ccagtccac  gggctccct  ggacaggaa  tacagtgtg  3240
tgtacacct  tgcaccaag  aaacctaaa  aactatttt  cactattga  ttttttcca  3300
tcatttgac  aatagtcta  atttaataa  atttt  3335



<210> 1922
<211> 968
<212> PRT
<213> Rattus norvegicus
<308> Q63767
<400> 1922

Met Lys Tyr Leu Val Ser Val Gly Ala Gly Pro Ala Arg Arg Ala Gly 
  1               5                  10                  15
Gly Leu Glu Asp Val Ser Trp Gly Pro Arg Val Ser Arg Arg Pro Gln 
             20                  25                  30
Ser Tyr Arg Ala Ala Arg His Val Asn Glu Ser Leu Pro Arg Ser Ala 
         35                  40                  45
Phe Arg Val Pro Ala Ala His Gly Ala Ser Val Thr Pro Ser Ala Ala 
     50                  55                  60
Leu Gly Ser Gly Leu Pro Glu Thr Gln Pro Glu Ala Val Cys Arg Gly 
 65                  70                  75                  80
Thr Glu Lys Pro Arg Phe Ala Glu Gly Cys Lys Pro Ala Ala Ser Arg 
                 85                  90                  95
Asp Lys Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala Glu Ser 
             100                105                110
Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr Val Leu Glu 
         115                120                125
Arg Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu His Gly 
     130                135                140
Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val Gly Met 
 145                150                155                160
Tyr Asp Lys Lys Pro Ala Ala Pro Gly Pro Gly Pro Pro Ala Thr Pro 
                 165                170                175
Pro Gln Pro Gln Pro Ser Leu Pro Gln Gly Val His Thr Pro Val Pro 
             180                185                190
Pro Ala Ser Gln Tyr Ser Pro Met Leu Pro Thr Ala Tyr Gln Pro Gln 
         195                200                205
Pro Asp Asn Val Tyr Leu Val Pro Thr Pro Ser Lys Thr Gln Gln Gly 
     210                215                220
Leu Tyr Gln Ala Pro Gly Pro Asn Pro Gln Phe Gln Ser Pro Pro Ala 
 225                230                235                240
Lys Gln Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Ser Phe Pro 
                 245                250                255
Ser Pro Ala Thr Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Ser Pro 
             260                265                270
Ala Gln Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Thr Gly His Asp 
         275                280                285
Ile Tyr Gln Val Pro Pro Ser Leu Asp Thr Arg Ser Trp Glu Gly Thr 
     290                295                300
Lys Pro Pro Ala Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr 
 305                310                315                320
Val Tyr Glu Ala Ser Gln Ala Glu Gln Asp Glu Tyr Asp Thr Pro Arg 
                 325                330                335
His Leu Leu Ala Pro Gly Ser Gln Asp Ile Tyr Asp Val Pro Pro Val 
             340                345                350
Arg Gly Leu Leu Pro Asn Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro 
         355                360                365
Pro Met Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Asp Val 
     370                375                380
Tyr Asp Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His 
 385                390                395                400
His Ser Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp 
                 405                410                415
Gly Pro Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala 
             420                425                430
Lys Pro Lys Pro Phe Asp Pro Thr Arg His Pro Leu Ile Leu Ala Ala 
         435                440                445
Pro Pro Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro 
     450                455                460
Pro Ala Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly 
 465                470                475                480
Pro Gly Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu 
                 485                490                495
Val Ala Asp Gly Ser Val Ile Asp Asp Gly Val Tyr Ala Val Pro Pro 
             500                505                510
Pro Ala Glu Arg Glu Ala Pro Thr Asp Gly Lys Arg Leu Ser Ala Ser 
         515                520                525
Ser Thr Gly Ser Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val 
     530                535                540
Val Val Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Thr 
 545                550                555                560
Leu Ala Arg Leu Gln Gln Gly Val Ser Thr Thr Val Ala His Leu Leu 
                 565                570                575
Asp Leu Val Gly Ser Ala Ser Gly Pro Gly Gly Trp Arg Ser Thr Ser 
             580                585                590
Glu Pro Gln Glu Pro Pro Val Gln Asp Leu Lys Ala Ala Val Ala Ala 
         595                600                605
Val His Gly Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val 
     610                615                620
Ser Ser Ala Thr His Thr Ser Asp Arg Thr Leu His Ala Lys Leu Ser 
 625                630                635                640
Arg Gln Leu Gln Lys Met Glu Asp Val Tyr Gln Thr Leu Val Val His 
                 645                650                655
Gly Gln Val Leu Asp Ser Gly Arg Gly Gly Pro Gly Phe Thr Leu Asp 
             660                665                670
Asp Leu Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala 
         675                680                685
Lys Gln Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg 
     690                695                700
Arg Thr Lys Ala Pro Gly Pro Gly Pro Glu Gly Ser Ser Ser Leu His 
 705                710                715                720
Leu Asn Pro Thr Asp Lys Ala Ser Ser Ile Gln Ser Arg Pro Leu Pro 
                 725                730                735
Ser Pro Pro Lys Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu 
             740                745                750
Asn Ser Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln 
         755                760                765
Gly Lys Glu Glu Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly 
     770                775                780
Asn Ile Val Arg Gln Gly Lys Gly Gln Leu Glu Leu Gln Gln Leu Lys 
 785                790                795                800
Gln Phe Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp 
                 805                810                815
Leu Ala Asn Trp Thr Pro Ala Gln Pro Leu Val Pro Gly Arg Thr Gly 
             820                825                830
Gly Leu Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln 
         835                840                845
Cys Glu Ala Asn Leu Thr Thr Leu Thr Asp Ala Val Asp Ala Phe Phe 
     850                855                860
Thr Ala Val Ala Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser 
 865                870                875                880
Lys Phe Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr 
                 885                890                895
Leu Ser Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Lys Val Thr His 
             900                905                910
Tyr Ser Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr 
         915                920                925
Lys Ala Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met 
     930                935                940
Val Asp Arg Val Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg 
 945                950                955                960
Val Leu Gly Gln Leu Ala Ala Ala 
                 965



<210> 1923
<211> 3208
<212> DNA
<213> Homo sapiens
<308> AJ242987
<400> 1923

gaggcggca  ctgcgcggc  gcaccgggg  ggctgcggc  cgctcggag  cccgaggca  60
gcggcccgg  cagctcggt  tgcgccccc  cgagagccg  gccccaggc  cgccggaca  120
catgaacca  ctgaacgtg  tggccaaag  gctctatga  aatgtggcc  agtccccgg  180
tgagctctc  ttccgcaag  gtgacatca  gacggtgct  gagcaggac  cgcagggcc  240
ggacggctg  tggctctgc  cgctgcatg  gcgccaggg  atcgtgcct  ggaaccgcc  300
caagatctt  gtgggcatg  atgataaga  gccagcagg  cctggctcc  gccctcccg  360
caccccggc  cagcctcag  ctggcctcc  tgccccagc  cctccggcc  cccagtaca  420
gcccatgct  cccaacacc  accagcccc  gccagacag  gtctacctg  tgcccactc  480
cagcaaggc  cagcaaggc  tctaccaag  cccgggtcc  agccctcag  tccagtctc  540
cccagccaa  cagacatcc  ccttctcga  gcagacacc  catcacccg  ttcccagcc  600
ggccacaga  ctgtaccag  tgcccccag  gcctggagg  cctgcccag  atatttacc  660
ggtgccacc  tctgccggg  tggggcatg  catctacca  gtccccccg  ccatggaca  720
acgcagctg  gagggcacg  agcccccgg  aaaggtggt  gtgcccacc  gcgtggggc  780
gggctatgt  tacgaggcc  cccagccgg  gcaggacga  tacgacatc  cgcgacacc  840
gctggcccc  gggccacag  acatctatg  tgtgccccc  gttcggggg  tgcttccca  900
ccagtatgg  caggaggtg  atgacacac  ccccatggc  gtcaagggt  ccaatggcc  960
agacccgtt  ctggaggtg  atgacgtgc  ccccagtgt  gagaagggc  tgccaccgt  1020
caaccacca  gcagtctac  acgttcctc  atcggtgag  aaggatgtg  ccgatggcc  1080
actgctgcg  gaggagacc  acgatgtgc  ccccgcctt  gccaaggcc  agccctttg  1140
cccggcccg  accccactg  tactggctg  gccccctcc  gactccccg  cggccgagg  1200
cgtgtatga  gtgccgccc  cggctcctg  cctctacga  gtgccccct  gcttgcggc  1260
gcctggccc  ggcaccctg  acgatgtgc  ccgtgaacg  gtgcttcct  ctgaggtgg  1320
tgatggtgg  gtggtcgac  gtggtgtgt  tgcggtgcc  cccccagct  aacgtgaag  1380
cccggcaga  ggcaagcgc  tgtcggcct  cagcaccgg  agcacacgc  gcagccagt  1440
tgcgtcctc  ttggaggtg  cagggccgg  ccgggaacc  ctggagctg  aagttgctg  1500
ggaggccct  gcacggctg  agcagggtg  gagcgccac  gttgcccac  ttctggacc  1560
ggcaggcag  gccggtgcg  ctgggagct  gcgtagccc  tctgagcca  aggagccgc  1620
ggtgcagga  ctgcaggct  ctgtggccg  tgtccagag  gccgtccac  agctgttgg  1680
gtttgcccg  agcgcggtg  gcaatgctg  ccacacatc  gaccgtgcc  tgcatgcca  1740
gcttagccg  cagctgcag  agatggagg  cgtgcacca  acgctggtg  cacatggtc  1800
ggccctcga  gctggccgg  gaggctctg  agccaccct  gaggacctg  accggctgg  1860
ggcctgctc  cgggctgtg  ccgaggacg  caagcagct  gcctccttc  tgcacggca  1920
tgcctcact  ctcttcaga  ggaccaagg  cactgcccc  gggcctgag  ggggtggca  1980
cctgcaccc  aaccccact  acaagacca  cagcatcca  tcacgaccc  tgccctcac  2040
ccctaagtt  acctcccag  actcaccag  tgggcagta  gagaacagc  aggggggct  2100
gatggagga  tatgactac  tccacctac  ggggaagga  gagtttgag  agacccaga  2160
ggagctgct  gaaaagggc  gcatcacgc  gcagggcaa  agccagctg  agttgcagc  2220
gctgaagca  tttgaacga  tggaacagg  ggtgtcacg  cccatagac  acgacctgg  2280
caactggac  ccagcccaa  ccctggccc  ggggcgaac  ggcggcctg  ggccctcgg  2340
ccggcagct  ctgctcttc  acctggagc  gtgtgaggc  aacctgacc  cactgacca  2400
cgccgtgga  gccttcttt  ccgccgtgg  caccaacca  ccgcccaag  tctttgtgg  2460
gcacagcaa  ttcgtcatc  tcagcgccc  caagctggt  ttcatcggg  acacactgt  2520
acggcaggc  aaggctgct  acgtgcgca  ccaggtgac  cactacagc  acctgctgt  2580
cgacctcct  cgcggcatc  tggccacca  caaggccgc  gccttgcag  acccatcgc  2640
ttccgcggc  caggacatg  tggagaggg  caaggagct  ggccacagc  cccagcagt  2700
ccgccgcgt  ctaggccag  tggcagccg  ctgagggtg  tgaccccag  agggaggca  2760
gggaggggt  cggcggtcc  agctccctg  ctcccatgt  aagagtcgc  gtgccacag  2820
cttagggac  ggaccccag  tctgcgtcg  tcctggtgc  ctggatgcc  aggaatctg  2880
atatattta  ggccgggca  ggtgtgggg  catgcctcc  caggagccg  agcccaggg  2940
ccgcagtgg  cttccccag  atgcaccac  ggcccgggt  gggtcacca  acggggctg  3000
agtgtgagg  tcctgcagc  tgcaggacc  cgtgccacc  cgagggctg  gcctggtcc  3060
acgagggtg  cgtgtcccc  gacagggcc  gtgcagttt  gtgtgtcct  cgccttacc  3120
ggagaagaa  ctgaagaac  atttttcgt  attggtttt  caatcattt  actaagagt  3180
tccatttaa  taaagtttt  aaaaggaa  3208



<210> 1924
<211> 870
<212> PRT
<213> Homo sapiens
<308> P56945
<400> 1924

Met Asn His Leu Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala 
  1               5                  10                  15
Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr Val 
             20                  25                  30
Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu 
         35                  40                  45
His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val 
     50                  55                  60
Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Ser Gly Pro Pro Ala 
 65                  70                  75                  80
Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala 
                 85                  90                  95
Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro Gln Pro Asp 
             100                105                110
Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln Gly Leu Tyr 
         115                120                125
Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln 
     130                135                140
Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Pro Phe Pro Ser Pro 
 145                150                155                160
Ala Thr Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln 
                 165                170                175
Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr 
             180                185                190
Gln Val Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr Lys Pro 
         195                200                205
Pro Ala Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr Val Tyr 
     210                215                220
Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu 
 225                230                235                240
Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly 
                 245                250                255
Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro Pro Met 
             260                265                270
Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp 
         275                280                285
Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala 
     290                295                300
Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro 
 305                310                315                320
Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala 
                 325                330                335
Lys Pro Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Ala Ala Pro Pro 
             340                345                350
Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala 
         355                360                365
Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly 
     370                375                380
Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala 
 385                390                395                400
Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala 
                 405                410                415
Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Thr 
             420                425                430
Gly Ser Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly 
         435                440                445
Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala 
     450                455                460
Arg Leu Gln Gln Gly Val Ser Ala Thr Val Ala His Leu Leu Asp Leu 
 465                470                475                480
Ala Gly Ser Ala Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser Glu Pro 
                 485                490                495
Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln 
             500                505                510
Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn 
         515                520                525
Ala Ala His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln 
     530                535                540
Leu Gln Lys Met Glu Asp Val His Gln Thr Leu Val Ala His Gly Gln 
 545                550                555                560
Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu Asp Leu 
                 565                570                575
Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln 
             580                585                590
Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Thr 
         595                600                605
Lys Ala Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His Pro Asn 
     610                615                620
Pro Thr Asp Lys Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro 
 625                630                635                640
Pro Lys Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser 
                 645                650                655
Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys 
             660                665                670
Glu Glu Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile 
         675                680                685
Thr Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe 
     690                695                700
Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala 
 705                710                715                720
Asn Trp Thr Pro Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly Gly Leu 
                 725                730                735
Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu 
             740                745                750
Ala Asn Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe Thr Ala 
         755                760                765
Val Ala Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe 
     770                775                780
Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Ser 
 785                790                795                800
Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Thr His Tyr Ser 
                 805                810                815
Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr Lys Ala 
             820                825                830
Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu 
         835                840                845
Arg Val Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg Val Leu 
     850                855                860
Gly Gln Leu Ala Ala Ala 
 865                870



<210> 1925
<211> 1310
<212> DNA
<213> Rattus norvegicus
<308> D29960
<400> 1925

gcaggatgg  gatccgggt  cctgtgcag  cttcttggc  gcgccgtgc  tcagctcct  60
taccgggtt  ttccactcc  ggacgcctc  ttgaccagc  tttcggcga  gggctgctt  120
aggcagagc  ggcttcact  tgccctgct  cgatcgcgc  ctactatct  cgcgccccc  180
gtgtggcgt  acccacagc  caggtgccc  cggaccctg  gtatttttc  gtgctgctg  240
atgtgaagc  cttctcgcc  gaggaaatc  ctgtcaagg  ggttggtga  catgtggag  300
tccatgctc  gcatgagga  cgcccagat  aacatggat  cattgctcg  gagttccac  360
gccgatacc  cctgcctcc  ggcgtggac  ctgctgcag  gacctctgc  ctgtctcct  420
agggtgttc  gtctatcca  gccacacca  cgtcggccc  ggcctcact  ccgtcacca  480
ctgctgcca  gtaggggtc  cagcattac  ggaccgaac  gggaagcct  tttaggctc  540
cttttaaaa  gccgatctg  ctccactgc  cagccagat  tcccaatcg  tgtcaagac  600
gcctttccc  accacaact  gatgtcctc  cctgagacc  tcccaaccc  aaccctacc  660
gagccttag  gacctagac  cccttccta  gccctctcc  agctttcag  ccccaccca  720
gacatctct  tagaggcaa  acaaacact  ctgtcagga  ccaaggctc  catcagact  780
accccactt  gggcttctc  cacactcag  ctgcatttg  gagctgtag  acaccccac  840
gtgacagca  agtacaatg  agtcagcgc  cccctcctt  caatcctgt  acctaattc  900
ccacagtga  gtagactgc  taggctttc  acaccagaa  gctcaagcc  ggtccacca  960
actccagtc  ctgtaacct  acactcctc  gccccagcc  actgtctga  ttaaaactc  1020
aggcaccga  attcttgaa  actattctg  cctccaatt  ttgggactc  tattcctga  1080
aaaccagga  ccccaaact  aaattgtat  gacactcca  cttctccag  tgtgctaga  1140
caatgaaca  gaacctgtg  gctctctgt  ctggctccc  atctgcagt  agatgtctt  1200
gggagcccg  tccacatct  ccatcctct  aggttgcac  ttcactctg  acatttcct  1260
tctccccag  ccttcctgc  attagttcc  aataaatgc  cttgagattt  1310



<210> 1926
<211> 162
<212> PRT
<213> Rattus norvegicus
<308> P97541
<400> 1926

Met Glu Ile Arg Val Pro Val Gln Pro Ser Trp Leu Arg Arg Ala Ser 
  1               5                  10                  15
Ala Pro Leu Pro Gly Phe Ser Thr Pro Gly Arg Leu Phe Asp Gln Arg 
             20                  25                  30
Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ser Leu Cys Pro Ala 
         35                  40                  45
Ala Ile Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro Thr 
     50                  55                  60
Ala Gln Val Pro Thr Asp Pro Gly Tyr Phe Ser Val Leu Leu Asp Val 
 65                  70                  75                  80
Lys His Phe Ser Pro Glu Glu Ile Ser Val Lys Val Val Gly Asp His 
                 85                  90                  95
Val Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly Phe 
             100                105                110
Ile Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val Asp 
         115                120                125
Pro Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser Ile 
     130                135                140
Gln Ala Thr Pro Ala Ser Ala Gln Ala Ser Leu Pro Ser Pro Pro Ala 
 145                150                155                160
Ala Lys 
                 165



<210> 1927
<211> 691
<212> DNA
<213> Homo sapiens
<308> NM_001885
<400> 1927

gacccctca  actcaccta  ccaccatgg  catcgccat  caccacccc  ggatccgcc  60
ccccttctt  cctttccac  cccccagcc  cctctttga  cagttcttc  gagagcacc  120
gttggagtc  gatcttttc  cgacgtcta  ttccctgag  cccttctac  ttcggccac  180
ctccttcct  cgggcaccc  gctggtttg  cactggact  tcagagatg  gcctggaga  240
ggacaggtt  tctgtcaac  tggatgtga  gcacttctc  ccagaggaa  tcaaagtta  300
ggtgttggg  gatgtgatt  aggtgcatg  aaaacatga  gagcgccag  atgaacatg  360
tttcatctc  agggagttc  acaggaaat  ccggatccc  gctgatgta  accctctca  420
cattacttc  tccctgtca  ctgatgggg  cctcactgt  aatggacca  ggaaacagg  480
ctctggccc  gagcgcacc  ttcccatca  ccgtgaaga  aagcctgct  tcaccgcag  540
ccccaagaa  tagatgccc  ttcttgaat  gcatttttt  aaacaagaa  gtttcccca  600
cagtgaatg  aagtcttgt  actagtgct  aagcttatt  atgctaagg  caggcccaa  660
ttatcaagc  aataaaata  cattcagca  c  691



<210> 1928
<211> 175
<212> PRT
<213> Homo sapiens
<308> P02511
<400> 1928

Met Asp Ile Ala Ile His His Pro Trp Ile Arg Arg Pro Phe Phe Pro 
  1               5                  10                  15
Phe His Ser Pro Ser Arg Leu Phe Asp Gln Phe Phe Gly Glu His Leu 
             20                  25                  30
Leu Glu Ser Asp Leu Phe Pro Thr Ser Thr Ser Leu Ser Pro Phe Tyr 
         35                  40                  45
Leu Arg Pro Pro Ser Phe Leu Arg Ala Pro Ser Trp Phe Asp Thr Gly 
     50                  55                  60
Leu Ser Glu Met Arg Leu Glu Lys Asp Arg Phe Ser Val Asn Leu Asp 
 65                  70                  75                  80
Val Lys His Phe Ser Pro Glu Glu Leu Lys Val Lys Val Leu Gly Asp 
                 85                  90                  95
Val Ile Glu Val His Gly Lys His Glu Glu Arg Gln Asp Glu His Gly 
             100                105                110
Phe Ile Ser Arg Glu Phe His Arg Lys Tyr Arg Ile Pro Ala Asp Val 
         115                120                125
Asp Pro Leu Thr Ile Thr Ser Ser Leu Ser Ser Asp Gly Val Leu Thr 
     130                135                140
Val Asn Gly Pro Arg Lys Gln Val Ser Gly Pro Glu Arg Thr Ile Pro 
 145                150                155                160
Ile Thr Arg Glu Glu Lys Pro Ala Val Thr Ala Ala Pro Lys Lys 
                 165                170                175



<210> 1929
<211> 1984
<212> DNA
<213> Rattus norvegicus
<308> D30041
<400> 1929

gccgcttag  aagccttca  tttggatcc  aaggcctcc  tgatcctgc  cctggagct  60
tgttagcac  gttctttct  agtcctgtt  ctgcgcgtg  tacgcttac  cacctgcct  120
cttgggcac  caagctcgg  actggattt  cactgacct  gtatctgat  ttctaaaag  180
ccttcacta  attaagact  tactgtatc  gaggagcct  ctacatgtc  tgctgccct  240
agctctctc  agctaggtg  cagcgtgtt  atgctgcca  catgaatga  gtatctgtc  300
tcaaagaag  ctggctcca  aaacgtggt  aatacatca  gacctggag  ccccggtac  360
tccttctga  gagtgatgg  tcttttatt  ggtataaag  gagacctga  gcccccgac  420
agaccctac  cccccttaa  aatttctct  tagcagaat  ccagctgat  aagactgag  480
ggccacgac  caacacctt  gtcatacgc  gcctgcagt  gaccacagt  atcgagagg  540
ccttccatg  cgactctcc  gatgagagg  aagagtgga  acgggctat  cagatggta  600
ccaacagtc  gaagcagcg  ggccccggg  aggatgcca  ggattacaa  tgtggctcc  660
ccagtgact  ttccacatc  gagatgatg  aggtagcgg  cagcaaggc  cgggccaaa  720
tgaccatga  cgacttcga  tatctcaaa  tcctcggca  gggcacctt  ggcaaagtc  780
ttctagttc  agagaaggc  actggccgc  attatgcca  gaagatcct  cggaaggag  840
tcatcattg  aaaggatga  gtcgcccac  cagtcacag  gagccgagt  ctacagaat  900
ccaggcacc  cttccttac  gccctgaag  atgccttcc  gacccatga  cgcctgtgc  960
ttgtgatgg  gtatgccaa  gggggcgac  tgtttttcc  cctctctcg  gagcgagtc  1020
tcacggagg  tcgggcacg  ttttatggt  cagagattg  gtcagctct  gagtacttg  1080
actcgacgg  tgtggtgta  cgcgacatc  agctggaaa  ccttatgct  gacaaagat  1140
gccacatca  gatcactga  tttggcttg  ccaaagagg  catcagtga  ggggccacc  1200
tgaaaacct  ctgtggtac  ccggagtac  tggcgcctg  ggtgctaga  gacaatgac  1260
acgggcgtg  agtggactg  tggggactg  gcgtggtca  gtacgagat  atgtgcggc  1320
gcctgccct  ctacaacca  gaccacgag  gcctcttcg  gctcatcct  atggaggag  1380
tccggttcc  acgcacgct  gggccagag  ccaagtccc  gctggctgg  ctgctcaag  1440
aggacccca  gcagaggct  ggtgggggt  ccagtgatg  caaggaggt  atggagcat  1500
ggttcttcc  cagcatcaa  tggcaggat  tggtacaga  gaagctcct  ccacccttc  1560
aacctcagg  cacttcaga  gtggacaca  ggtactttg  tgatgaatt  accgcccag  1620
ccatcacaa  cacaccccc  gaccgatat  acagcctgg  ctcgctgga  ctggaccag  1680
gcacacact  cccccagtt  tcctactca  ccagcatcc  agagtgagc  gccctctgc  1740
accacagga  acagcatgg  cgccatcca  tgcctgggt  gctttttaa  aaaaacttt  1800
ttttgcctt  ggtttgcgt  cccttccct  tcccctcat  ccatatcca  tttcttctt  1860
agttcttgc  cagacttag  ggtcctggc  ggcctctcc  ccgggctcc  ctctgctcc  1920
agaggagtg  tgggaacct  cccaaggac  ggccgttgg  aggatggag  gtgaggtta  1980
taat  1984



<210> 1930
<211> 481
<212> PRT
<213> Rattus norvegicus
<308> P47197
<400> 1930

Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
  1               5                  10                  15
Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
             20                  25                  30
Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Thr 
         35                  40                  45
Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
     50                  55                  60
Thr Glu Arg Pro Arg Pro Asn Thr Phe Val Ile Arg Cys Leu Gln Trp 
 65                  70                  75                  80
Thr Thr Val Ile Glu Arg Thr Phe His Val Asp Ser Pro Asp Glu Arg 
                 85                  90                  95
Glu Glu Trp Ile Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
             100                105                110
Arg Gly Pro Gly Glu Asp Ala Met Asp Tyr Lys Cys Gly Ser Pro Ser 
         115                120                125
Asp Ser Ser Thr Ser Glu Met Met Glu Val Ala Val Ser Lys Ala Arg 
     130                135                140
Ala Lys Val Thr Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys 
 145                150                155                160
Gly Thr Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Thr Gly Arg 
                 165                170                175
Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu Val Ile Ile Ala Lys Asp 
             180                185                190
Glu Val Ala His Thr Val Thr Glu Ser Arg Val Leu Gln Asn Thr Arg 
         195                200                205
His Pro Phe Leu Thr Ala Leu Lys Tyr Ala Phe Gln Thr His Asp Arg 
     210                215                220
Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Asp Leu Phe Phe His 
 225                230                235                240
Leu Ser Arg Glu Arg Val Phe Thr Glu Asp Arg Ala Arg Phe Tyr Gly 
                 245                250                255
Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Thr Asp Val Val 
             260                265                270
Tyr Arg Asp Ile Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His 
         275                280                285
Ile Lys Ile Thr Asp Phe Gly Leu Ser Lys Glu Gly Ile Ser Asp Gly 
     290                295                300
Ala Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
 305                310                315                320
Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu 
                 325                330                335
Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn 
             340                345                350
Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg 
         355                360                365
Phe Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ala Gly Leu 
     370                375                380
Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser Asp Ala 
 385                390                395                400
Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp Gln Asp 
                 405                410                415
Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val Thr Ser 
             420                425                430
Glu Val Asp Thr Arg Tyr Phe Asp Asp Glu Phe Thr Ala Gln Ser Ile 
         435                440                445
Thr Ile Thr Pro Pro Asp Arg Tyr Asp Ser Leu Gly Ser Leu Glu Leu 
     450                455                460
Asp Gln Arg Thr His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Ile Arg 
 465                470                475                480
Glu 
                 485



<210> 1931
<211> 3402
<212> DNA
<213> Homo sapiens
<308> AK054771
<400> 1931

atttttgag  agtcttact  tgttgagtg  agtggtgtg  tctcggctc  ctgcaacct  60
tgcctcccg  gttcaagcg  ttgtcctgc  tcagcctcc  gaataggtg  gattacagg  120
gcccgccac  atgcccagc  aatttttgt  tttttagta  agacggggt  tcatcatat  180
ggccaggct  gtctcaaac  cctgacctt  tgatccacc  acctcagcc  cccaaagtg  240
ttggattac  ggcatgagc  cccgcgccc  gccaagttt  gaagatagt  tggcagtgt  300
caccaaagc  gagcaccag  catctgccc  agctgtgtg  acaggagaa  tggggacac  360
cactcacct  agaaagtgt  cccctcact  agcagcagg  cttactcta  ccccaactg  420
aacaaccca  gtatccact  tgagaggaa  agtcagatc  actgtggag  gttctcaca  480
tgggacgcc  cacagcagt  aggaatgag  tacagctac  cacgacagt  tggacgcgt  540
tcataggct  atgtcgagg  aaagccgca  agaggaggt  agtccacag  tcacaggtg  600
gtctgtgtg  agtggtaca  atgggaagt  gaggttaat  cttgtgggg  atggtcagt  660
accgggagg  gcacacagg  ccttccagg  ggagatgcc  cctcagcct  gcaagtagc  720
gggactata  gtgtgtgcc  ccatgcctg  ctaattttt  ttttcatat  aagaaatat  780
gagatgggg  ctcgctgtg  tgcccaggc  ggtctcaaa  tcatgggtt  aagcaatcc  840
gccacctaa  tcccccaaa  tgctgggat  acaggtgtg  gccactttg  ctggctgca  900
atttcataa  taaaggaca  aaagtctag  aaaaaagaa  agaagaaag  tagtgcccc  960
acgttcgaa  taagaacca  agttcacaa  ggggacggt  ggtggacag  gcctggctc  1020
cggctctcc  tgcccagct  ttcccaggt  ccatggggg  gggccagag  gtgaggagg  1080
ttggatctg  cctctctct  agcctcaga  ggtgaggct  tgtgtgctg  gcccagcct  1140
gcatgggag  gttgatgtc  aggagcccc  ggcatcttt  cctggaagg  aaggctggg  1200
tggcaggaa  ccttgggag  atgcgcctg  gatccgttg  cttttccaa  agctggaaa  1260
cctcatgct  gacaaagat  gccacatca  gatcactga  tttggcctc  gcaaagagg  1320
catcagtga  ggggccacc  tgaaaacct  ctgtgggac  ccggagtac  tggcgcctg  1380
ggtgctgga  gacaatgac  atggccggg  cgtggactg  tgggggctg  gtgtggtca  1440
gtacgagat  atgtgcggc  gcctgccct  ctacaacca  gaccacgag  gcctcttcg  1500
gctcatcct  atggaagag  tccgcttcc  gcgcacgct  agcctcgag  ccaagtccc  1560
gcttgctgg  ctgcttaag  aggacccca  gcagaggct  ggtgggggg  ccagcgatg  1620
caaggaggt  atggagcac  ggttcttcc  cagcatcaa  tggcaggac  tggtccaga  1680
gaagctcct  ccacccttc  aacctcagg  cacgtccga  gtcgacaca  ggtacttcg  1740
tgatgaatt  accgcccag  ccatcacaa  cacaccccc  gaccgctat  acagcctgg  1800
cttactgga  ctggaccag  ggacccact  cccccagtt  tcctactcg  ccagcatcc  1860
cgagtgagc  gtctgccca  gcagaggac  cacgctcgc  gccatcacc  ctgggtggt  1920
ttttacccc  aacttttta  ttagccttt  tggtttgtg  ccccacccc  acctcctca  1980
cccctttcc  gttcttctt  aggcccctc  cagacgcac  ccagcggcc  ctgcagccc  2040
tgcctccag  ctccagcct  acctttgtg  ccagactcg  atttggaag  ctccacctc  2100
cgcccaggc  tgggctgtt  ggcggttgg  gactcaggt  ttaatccac  caagcccca  2160
tgaggggtg  agcatggcg  ctggggcct  cctgagttt  tggcctggg  gtcgtgctg  2220
tgtctgcct  cgcgctgct  catctggac  aaggctgcc  tctggtggg  cgcgacacc  2280
ggcagacag  ggtgctgcc  tccaggccc  gtggcctag  ctcggagtg  ccaggcacg  2340
ggcggtcca  tcccccacc  gctgtcccc  tatgggggc  gaaaagcaa  aatgtccag  2400
ggcaggcag  ggcccttgg  agctgcagg  ctgggggtt  gggctgctc  ctggtgaat  2460
gagtcagat  ctaggatct  taccatggg  aaccaggag  ggccgggct  ggtgccgcc  2520
cctggtccg  cctcctccc  accaaactg  cctcaccct  tggatgagg  aggaggaac  2580
tttggggcc  aacctgcct  cctcccagc  ccgtgcctt  ctagggctt  cttccagct  2640
gccttacct  ccgctggac  ctgggcctg  cctggcccc  ctgggggct  tgggctggg  2700
tcaccctct  ctctgcggg  gtggagggc  accagcctt  gctgttaca  tcttacacc  2760
gacagtatt  ggccccatg  acttggtca  ggaggggtg  gggtgggca  ctctggtac  2820
tattggggt  gggggcctc  gaaaaggga  gctcctagg  ccccctcac  cctccctct  2880
cccagggcc  cacgttctg  agccttaag  ttgaacatg  gtgcacgtc  atgtcagtg  2940
tgtgggact  ctgtgcgtg  ctcggactg  gtgtgccgg  gggacgcag  cacacgtgg  3000
tgtgtgtgc  tgtgtgttt  tgtgagggc  gcgtgtcct  cagtgtgca  ggtgtgtgg  3060
cttgggccc  atccctggc  cgagcattt  atcctgtgg  ggaggggtg  tgacctagt  3120
ggaggagcc  cactgtgat  catgagctg  cctgcccac  cctcccctc  ctgtagcaa  3180
acctctggg  gtttggagt  tagcttttg  gggtttgct  tccctatcc  atctcctgt  3240
ctacacagt  catggcagg  tggggaggg  tggggttgg  tcgggtggg  gagggtctt  3300
ttcctctgt  tgcgatgtt  ttatctgac  gttctccgt  cctactggc  tttctcctc  3360
tcttcatat  tgtacggta  aagcaataa  gacactcat  tc  3402



<210> 1932
<211> 481
<212> PRT
<213> Homo sapiens
<308> P31751
<400> 1932

Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
  1               5                  10                  15
Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
             20                  25                  30
Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Thr 
         35                  40                  45
Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
     50                  55                  60
Thr Glu Arg Pro Arg Pro Asn Thr Phe Val Ile Arg Cys Leu Gln Trp 
 65                  70                  75                  80
Thr Thr Val Ile Glu Arg Thr Phe His Val Asp Ser Pro Asp Glu Arg 
                 85                  90                  95
Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
             100                105                110
Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser 
         115                120                125
Asp Ser Ser Thr Thr Glu Glu Met Glu Val Ala Val Ser Lys Ala Arg 
     130                135                140
Ala Lys Val Thr Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys 
 145                150                155                160
Gly Thr Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Thr Gly Arg 
                 165                170                175
Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu Val Ile Ile Ala Lys Asp 
             180                185                190
Glu Val Ala His Thr Val Thr Glu Ser Arg Val Leu Gln Asn Thr Arg 
         195                200                205
His Pro Phe Leu Thr Ala Leu Lys Tyr Ala Phe Gln Thr His Asp Arg 
     210                215                220
Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His 
 225                230                235                240
Leu Ser Arg Glu Arg Val Phe Thr Glu Glu Arg Ala Arg Phe Tyr Gly 
                 245                250                255
Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Arg Asp Val Val 
             260                265                270
Tyr Arg Asp Ile Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His 
         275                280                285
Ile Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Ser Asp Gly 
     290                295                300
Ala Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
 305                310                315                320
Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu 
                 325                330                335
Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn 
             340                345                350
Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg 
         355                360                365
Phe Pro Arg Thr Leu Ser Pro Glu Ala Lys Ser Leu Leu Ala Gly Leu 
     370                375                380
Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser Asp Ala 
 385                390                395                400
Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp Gln Asp 
                 405                410                415
Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val Thr Ser 
             420                425                430
Glu Val Asp Thr Arg Tyr Phe Asp Asp Glu Phe Thr Ala Gln Ser Ile 
         435                440                445
Thr Ile Thr Pro Pro Asp Arg Tyr Asp Ser Leu Gly Leu Leu Glu Leu 
     450                455                460
Asp Gln Arg Thr His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Ile Arg 
 465                470                475                480
Glu 
                 485



<210> 1933
<211> 2117
<212> DNA
<213> Rattus norvegicus
<308> D30647
<400> 1933

aattccgcg  cggctttgg  gatgcagtc  gcccggatg  ccccgagtg  ggggcgaca  60
ctgctgcgg  tgggggccc  aagctcgcg  tctgctgcg  ttcagggac  accccggcc  120
acctctgcc  agcgacttt  tgccagtga  gccactcag  cagttctgg  aaagccaga  180
accctctcc  ctgatgctt  caccagaga  aaacctgcc  gggcggaat  taagtcttt  240
gctgtggga  tgttcaaag  ccagcttac  accgaccag  tgttcccat  cccatctgt  300
ctcaatgaa  gacagacac  atttctcaa  gagctggtg  gaccagtgg  ccggttctt  360
gaagaagtg  atgaccctg  caagaatga  tccttggag  aggtggagg  ggacacttt  420
cagggactc  aagaactgg  ggcatttgg  ctgcaagta  ccagcgagc  gggtggttt  480
ggcctctct  atacccagt  cgctcgctt  gcagagatt  tgggcatgc  tgaccttgg  540
gttagcgtt  ccctgggag  ccatcagag  atcggtttc  aaggcatct  gctctatgg  600
acaaaggcc  agaaggaaa  atacctccc  agagtggca  ccgggcagg  tttggcggc  660
ttctgcctg  ctgagccct  gagcgggtc  gatgtggcc  ctatccgaa  ctcagctgt  720
cctagcccc  gtggaaagt  ttatactct  aacggaagc  agatctgga  cagtaatgg  780
ggtctggca  acattttca  tgtctttgc  aaaacgcca  ttaaagatg  agccacggg  840
gccgtgaaa  agaagatca  agctttcgt  gtggaacgg  gctttggag  ggttaccca  900
gggctcccc  aaaagaaga  gggcatcaa  gcatctaac  catcagagg  gtactttga  960
ggagtcaag  tgccagcag  gaatgtgct  ggagaagtg  gagatggct  caaggttgc  1020
gtcaacatc  tcaacaacg  aagatttgg  atggctgca  ccctagcag  caccatgaa  1080
gccatcatt  ccaaggcgg  tgatcatgc  actaaccgt  cccagtttg  ggacaaaat  1140
cacaacttt  gggtgatcc  ggaaaagct  gctcggatg  ctattctgc  gtatgtgac  1200
gagtccatg  cttacatgc  gagtgccaa  atggaccag  gattcaaag  cttccagat  1260
gaagctgcc  tcagcaaaa  ctttggctc  gaggcggcc  ggaaagtga  agatgagtg  1320
atccagata  tggggggca  gggcttcat  aaggaacca  gggtagagc  tgtgctccg  1380
gatattcga  tcttccgga  ctttgaagg  acaaatgac  ttcttcgac  gtttgtggc  1440
ctacaaggc  gcatggaca  aggaaagga  ctcacggga  ttggtaatg  cctaaagaa  1500
cctcttgga  atgttggcc  cctcatagg  gaagcaagc  aacagctga  gcggcggac  1560
gggattggc  gtggtctga  tctctcggg  attgtccac  cagagttga  tcgcagtgg  1620
gaactggca  tgcaggctc  ggaacaatt  gccactgta  tggaggcga  gctgatgaa  1680
cacaagaaa  ggattgtca  tgaacagtt  ctgctgcag  gactggcag  tggagccat  1740
gacctctac  ccatggtgg  ggttctctc  agagcctca  gatccctga  tgagggcta  1800
ccgacagca  agcatgaga  aatgctctg  gatagttgg  gcattgagg  tgcaacacg  1860
attcgagaa  acatggcca  ccttcagtc  aaccctcag  agcaggagc  ctttcgtaa  1920
ttcagaagt  tctccaagg  catggtgga  aatggtggc  tggtcacca  taaccccct  1980
agagtctga  gactcctaa  caggcccta  cacagtcgt  tgccttctt  tatgccaaa  2040
acaggcccc  ttcatgggg  cactggagt  cttactgcc  taaggacaa  aaattttct  2100
ccaaaaaaa  aaaaaaa  2117



<210> 1934
<211> 655
<212> PRT
<213> Rattus norvegicus
<308> P45953
<400> 1934

Met Gln Ser Ala Arg Met Thr Pro Ser Val Gly Arg Gln Leu Leu Arg 
  1               5                  10                  15
Leu Gly Ala Arg Ser Ser Arg Ser Ala Ala Leu Gln Gly Gln Pro Arg 
             20                  25                  30
Pro Thr Ser Ala Gln Arg Leu Tyr Ala Ser Glu Ala Thr Gln Ala Val 
         35                  40                  45
Leu Glu Lys Pro Glu Thr Leu Ser Ser Asp Ala Ser Thr Arg Glu Lys 
     50                  55                  60
Pro Ala Arg Ala Glu Ser Lys Ser Phe Ala Val Gly Met Phe Lys Gly 
 65                  70                  75                  80
Gln Leu Thr Thr Asp Gln Val Phe Pro Tyr Pro Ser Val Leu Asn Glu 
                 85                  90                  95
Gly Gln Thr Gln Phe Leu Lys Glu Leu Val Gly Pro Val Ala Arg Phe 
             100                105                110
Phe Glu Glu Val Asn Asp Pro Ala Lys Asn Asp Ser Leu Glu Lys Val 
         115                120                125
Glu Glu Asp Thr Leu Gln Gly Leu Lys Glu Leu Gly Ala Phe Gly Leu 
     130                135                140
Gln Val Pro Ser Glu Leu Gly Gly Leu Gly Leu Ser Asn Thr Gln Tyr 
 145                150                155                160
Ala Arg Leu Ala Glu Ile Val Gly Met His Asp Leu Gly Val Ser Val 
                 165                170                175
Thr Leu Gly Ala His Gln Ser Ile Gly Phe Lys Gly Ile Leu Leu Tyr 
             180                185                190
Gly Thr Lys Ala Gln Lys Glu Lys Tyr Leu Pro Arg Val Ala Ser Gly 
         195                200                205
Gln Ala Leu Ala Ala Phe Cys Leu Thr Glu Pro Ser Ser Gly Ser Asp 
     210                215                220
Val Ala Ser Ile Arg Ser Ser Ala Val Pro Ser Pro Cys Gly Lys Tyr 
 225                230                235                240
Tyr Thr Leu Asn Gly Ser Lys Ile Trp Ile Ser Asn Gly Gly Leu Ala 
                 245                250                255
Asp Ile Phe Thr Val Phe Ala Lys Thr Pro Ile Lys Asp Ala Ala Thr 
             260                265                270
Gly Ala Val Lys Glu Lys Ile Thr Ala Phe Val Val Glu Arg Ser Phe 
         275                280                285
Gly Gly Val Thr His Gly Leu Pro Glu Lys Lys Met Gly Ile Lys Ala 
     290                295                300
Ser Asn Thr Ser Glu Val Tyr Phe Asp Gly Val Lys Val Pro Ala Glu 
 305                310                315                320
Asn Val Leu Gly Glu Val Gly Asp Gly Phe Lys Val Ala Val Asn Ile 
                 325                330                335
Leu Asn Asn Gly Arg Phe Gly Met Ala Ala Thr Leu Ala Gly Thr Met 
             340                345                350
Lys Ala Ile Ile Ala Lys Ala Val Asp His Ala Thr Asn Arg Thr Gln 
         355                360                365
Phe Gly Asp Lys Ile His Asn Phe Gly Val Ile Gln Glu Lys Leu Ala 
     370                375                380
Arg Met Ala Ile Leu Gln Tyr Val Thr Glu Ser Met Ala Tyr Met Leu 
 385                390                395                400
Ser Ala Asn Met Asp Gln Gly Phe Lys Asp Phe Gln Ile Glu Ala Ala 
                 405                410                415
Ile Ser Lys Ile Phe Gly Ser Glu Ala Ala Trp Lys Val Thr Asp Glu 
             420                425                430
Cys Ile Gln Ile Met Gly Gly Met Gly Phe Met Lys Glu Pro Gly Val 
         435                440                445
Glu Arg Val Leu Arg Asp Ile Arg Ile Phe Arg Ile Phe Glu Gly Thr 
     450                455                460
Asn Asp Ile Leu Arg Leu Phe Val Ala Leu Gln Gly Cys Met Asp Lys 
 465                470                475                480
Gly Lys Glu Leu Thr Gly Leu Gly Asn Ala Leu Lys Asn Pro Leu Gly 
                 485                490                495
Asn Val Gly Leu Leu Ile Gly Glu Ala Ser Lys Gln Leu Arg Arg Arg 
             500                505                510
Thr Gly Ile Gly Ser Gly Leu Ser Leu Ser Gly Ile Val His Pro Glu 
         515                520                525
Leu Ser Arg Ser Gly Glu Leu Ala Val Gln Ala Leu Glu Gln Phe Ala 
     530                535                540
Thr Val Val Glu Ala Lys Leu Met Lys His Lys Lys Gly Ile Val Asn 
 545                550                555                560
Glu Gln Phe Leu Leu Gln Arg Leu Ala Asp Gly Ala Ile Asp Leu Tyr 
                 565                570                575
Ala Met Val Val Val Leu Ser Arg Ala Ser Arg Ser Leu Ser Glu Gly 
             580                585                590
Tyr Pro Thr Ala Gln His Glu Lys Met Leu Cys Asp Ser Trp Cys Ile 
         595                600                605
Glu Ala Ala Thr Arg Ile Arg Glu Asn Met Ala Ser Leu Gln Ser Asn 
     610                615                620
Pro Gln Gln Gln Glu Leu Phe Arg Asn Phe Arg Ser Ile Ser Lys Ala 
 625                630                635                640
Met Val Glu Asn Gly Gly Leu Val Thr Ser Asn Pro Leu Arg Val 
                 645                650                655



<210> 1935
<211> 2505
<212> DNA
<213> Homo sapiens
<308> AF006012
<400> 1935

gagaccatg  cgggtagca  cactggggg  ggtggggtt  gggagacga  ggtgattta  60
cacctggat  aggaagaga  tccctacct  gtgaagatc  ctgtccccg  cgagcgcat  120
accctcggc  atttcaaga  cgtcctgca  cggcccgcg  gcgccaagt  ctttttcaa  180
tctatggat  aggatttcg  ggtggtgaa  gaagaaatt  cagatgaca  cgcccgcct  240
ccctgcttc  acggaaggg  ggtatcctg  ctggtgtcc  cagataatc  ccaacccga  300
atggcccct  cagtccatg  gcctcgggc  gaactggcg  ctccagccc  acctttacc  360
cctttgcca  ccgagagga  cagcggcat  ggggactca  ggcctccat  tttccaccc  420
aatgtgtcc  gcagccatg  gaatctgga  cctgagaca  aaaccgagt  agtagtgtc  480
ctgaggcgg  agcggcctc  caggagaga  agcagtgag  atggcgctg  gggccacag  540
actggtggc  cctcaaggc  ggagcgcca  ctggccgga  acgagagct  ctctaccct  600
atgaccagc  agctggaga  taccagtct  ggggactcg  acgaggagg  caccatgag  660
aggttcagc  gctccacgg  gcagagcag  gcctcccgc  tccttaagc  ccaccggcg  720
cgaaggaag  agaggccgc  ccgcctgga  aggacgtca  ccttcagca  cgtcacaga  780
tccacaatg  ctctcaata  catcacagt  acgctaaac  tggagaagt  caacttcct  840
ggtatctcc  ttgttggcc  aagcaatga  cggggagac  gaggcatct  cattggctc  900
atcatgaag  gtggggctg  ggcggccga  gggcgcatt  agccagggg  catgctttt  960
caggtgaat  acatgaact  tgagaacat  agcaacgat  acgctgtgc  ggtgctgag  1020
gacattgtg  acaagcctg  ccccattgt  ctgactgtg  ccaagtgct  ggatccctc  1080
cctcaggcc  atttcactc  cccccgaaa  gagcccatc  agccaattg  ccctgctgc  1140
tgggtgtcc  attccgcgg  tctgactgg  accttccca  cctatccag  ttcctcctc  1200
atgagcacc  ttacatctg  atcgtcttt  cctgatggc  gtgaaggcc  gggtctctc  1260
gtccatacg  acatggcat  ggtgaccaa  gccatggca  ctccagagt  tggactgga  1320
gtccgggac  gcatgtggc  caagatcac  atccctaat  cctttctgg  ctcggatgt  1380
gttgactgg  tctaccatc  cgtggaggg  tttcctgag  ggcgggagg  ccgcaagta  1440
gccagcggg  tgctcaaag  aggcctgat  cgacacacc  tcaacaaga  caccttctc  1500
gagcagtgc  attacgtct  cggagacct  agtggtggc  gtgagagct  cctagtcaa  1560
ctgtctctc  atgacaacg  tggctccag  ggggcttca  accaggata  cctggctcc  1620
ctgcctggg  ccaccccct  gcccctgct  cccactttc  cctaccagt  ccctgcccc  1680
cacccctac  gcccgcagc  tccacccta  catgagctt  catcttaca  ctatggtgg  1740
ggcagtgcc  gcagccagc  tagtgaggg  agccggagc  gtgggtcga  acggagtga  1800
gggggggca  ggcgcacgg  gaggcccga  gagcgggcc  ccgagtcca  gtccggcag  1860
ggcagtgag  ctgagccct  cagccgagg  ggcagcctt  ggcggggtg  ggaagcaag  1920
gggactagc  atgggggcc  tcctccatc  agaggctca  ctgggggtg  ccctaatct  1980
cgagcccac  cagggctcc  tccctatgg  ccgccccct  gcatggccc  cccctacaa  2040
cccatgatg  tggtcatga  gcccccacc  ccacctcca  tccctccag  agtgcagcc  2100
ccgggggcc  ctccagtca  agacctggg  tctgtgccc  cagaactga  agccagccg  2160
caaagcttc  acatggcca  gggcaatcc  agcgagttc  ttgtggatg  tatgtagcc  2220
actgtgggg  caggctggg  cgggcgctc  tggtgtgtg  ctgggtgtc  tggccgtca  2280
gtgcttgct  ttacagtgc  tgggctcag  ctaccagct  ctgccatac  ggagattgt  2340
gccactgtg  ctctcacca  cagtgcctg  ttcctcccc  ttggctcag  ggtagacaa  2400
ggacctttg  ttattttta  ctttgtttt  ttataagcc  ttttggggg  taaaataga  2460
tttcttaca  ttttgggac  ttttttaat  ggcatttcc  ctttt  2505



<210> 1936
<211> 736
<212> PRT
<213> Homo sapiens
<308> O14641
<400> 1936

Met Ala Gly Ser Ser Thr Gly Gly Gly Gly Val Gly Glu Thr Lys Val 
  1               5                  10                  15
Ile Tyr His Leu Asp Glu Glu Glu Thr Pro Tyr Leu Val Lys Ile Pro 
             20                  25                  30
Val Pro Ala Glu Arg Ile Thr Leu Gly Asp Phe Lys Ser Val Leu Gln 
         35                  40                  45
Arg Pro Ala Gly Ala Lys Tyr Phe Phe Lys Ser Met Asp Gln Asp Phe 
     50                  55                  60
Gly Val Val Lys Glu Glu Ile Ser Asp Asp Asn Ala Arg Leu Pro Cys 
 65                  70                  75                  80
Phe Asn Gly Arg Val Val Ser Trp Leu Val Ser Ser Asp Asn Pro Gln 
                 85                  90                  95
Pro Glu Met Ala Pro Pro Val His Glu Pro Arg Ala Glu Leu Ala Pro 
             100                105                110
Pro Ala Pro Pro Leu Pro Pro Leu Pro Pro Glu Arg Thr Ser Gly Ile 
         115                120                125
Gly Asp Ser Arg Pro Pro Ser Phe His Pro Asn Val Ser Ser Ser His 
     130                135                140
Glu Asn Leu Glu Pro Glu Thr Glu Thr Glu Ser Val Val Ser Leu Arg 
 145                150                155                160
Arg Glu Arg Pro Arg Arg Arg Asp Ser Ser Glu His Gly Ala Gly Gly 
                 165                170                175
His Arg Thr Gly Gly Pro Ser Arg Leu Glu Arg His Leu Ala Gly Tyr 
             180                185                190
Glu Ser Ser Ser Thr Leu Met Thr Ser Glu Leu Glu Ser Thr Ser Leu 
         195                200                205
Gly Asp Ser Asp Glu Glu Asp Thr Met Ser Arg Phe Ser Ser Ser Thr 
     210                215                220
Glu Gln Ser Ser Ala Ser Arg Leu Leu Lys Arg His Arg Arg Arg Arg 
 225                230                235                240
Lys Gln Arg Pro Pro Arg Leu Glu Arg Thr Ser Ser Phe Ser Ser Val 
                 245                250                255
Thr Asp Ser Thr Met Ser Leu Asn Ile Ile Thr Val Thr Leu Asn Met 
             260                265                270
Glu Lys Tyr Asn Phe Leu Gly Ile Ser Ile Val Gly Gln Ser Asn Glu 
         275                280                285
Arg Gly Asp Gly Gly Ile Tyr Ile Gly Ser Ile Met Lys Gly Gly Ala 
     290                295                300
Val Ala Ala Asp Gly Arg Ile Glu Pro Gly Asp Met Leu Leu Gln Val 
 305                310                315                320
Asn Asp Met Asn Phe Glu Asn Met Ser Asn Asp Asp Ala Val Arg Val 
                 325                330                335
Leu Arg Asp Ile Val His Lys Pro Gly Pro Ile Val Leu Thr Val Ala 
             340                345                350
Lys Cys Trp Asp Pro Ser Pro Gln Ala Tyr Phe Thr Leu Pro Arg Asn 
         355                360                365
Glu Pro Ile Gln Pro Ile Asp Pro Ala Ala Trp Val Ser His Ser Ala 
     370                375                380
Ala Leu Thr Gly Thr Phe Pro Ala Tyr Pro Gly Ser Ser Ser Met Ser 
 385                390                395                400
Thr Ile Thr Ser Gly Ser Ser Leu Pro Asp Gly Cys Glu Gly Arg Gly 
                 405                410                415
Leu Ser Val His Thr Asp Met Ala Ser Val Thr Lys Ala Met Ala Ala 
             420                425                430
Pro Glu Ser Gly Leu Glu Val Arg Asp Arg Met Trp Leu Lys Ile Thr 
         435                440                445
Ile Pro Asn Ala Phe Leu Gly Ser Asp Val Val Asp Trp Leu Tyr His 
     450                455                460
His Val Glu Gly Phe Pro Glu Arg Arg Glu Ala Arg Lys Tyr Ala Ser 
 465                470                475                480
Gly Leu Leu Lys Ala Gly Leu Ile Arg His Thr Val Asn Lys Ile Thr 
                 485                490                495
Phe Ser Glu Gln Cys Tyr Tyr Val Phe Gly Asp Leu Ser Gly Gly Cys 
             500                505                510
Glu Ser Tyr Leu Val Asn Leu Ser Leu Asn Asp Asn Asp Gly Ser Ser 
         515                520                525
Gly Ala Ser Asp Gln Asp Thr Leu Ala Pro Leu Pro Gly Ala Thr Pro 
     530                535                540
Trp Pro Leu Leu Pro Thr Phe Ser Tyr Gln Tyr Pro Ala Pro His Pro 
 545                550                555                560
Tyr Ser Pro Gln Pro Pro Pro Tyr His Glu Leu Ser Ser Tyr Thr Tyr 
                 565                570                575
Gly Gly Gly Ser Ala Ser Ser Gln His Ser Glu Gly Ser Arg Ser Ser 
             580                585                590
Gly Ser Thr Arg Ser Asp Gly Gly Ala Gly Arg Thr Gly Arg Pro Glu 
         595                600                605
Glu Arg Ala Pro Glu Ser Lys Ser Gly Ser Gly Ser Glu Ser Glu Pro 
     610                615                620
Ser Ser Arg Gly Gly Ser Leu Arg Arg Gly Gly Glu Ala Ser Gly Thr 
 625                630                635                640
Ser Asp Gly Gly Pro Pro Pro Ser Arg Gly Ser Thr Gly Gly Ala Pro 
                 645                650                655
Asn Leu Arg Ala His Pro Gly Leu His Pro Tyr Gly Pro Pro Pro Gly 
             660                665                670
Met Ala Leu Pro Tyr Asn Pro Met Met Val Val Met Met Pro Pro Pro 
         675                680                685
Pro Pro Pro Val Pro Pro Ala Val Gln Pro Pro Gly Ala Pro Pro Val 
     690                695                700
Arg Asp Leu Gly Ser Val Pro Pro Glu Leu Thr Ala Ser Arg Gln Ser 
 705                710                715                720
Phe His Met Ala Met Gly Asn Pro Ser Glu Phe Phe Val Asp Val Met 
                 725                730                735



<210> 1937
<211> 2744
<212> DNA
<213> Rattus norvegicus
<308> D30649
<400> 1937

tgaggacag  tcctttttc  ctccctaga  gaaagaaag  gccttattt  ctggctaaa  60
aggtttaca  agctacagg  acaatggat  ccaggctag  tttagccac  gaggagccc  120
ttaagaaag  cagcctgaa  agatataag  tcctttgtg  ggttcttct  gctttgctg  180
tgatcgtgt  gcttggatt  ggcctgggc  tgggactca  gaaacctga  gagcatata  240
gcagctgca  gaaaaaatg  tttgattcg  cacacagag  actggaggg  tgccgctgt  300
actccggat  cacagaccg  ggagactgc  gctgggact  tgaagatac  tgtgtgaaa  360
caactcaaa  ctggacgtg  aattcgttc  gctgtgggg  gaccagact  gagacagcc  420
tctgttcct  tgcggatga  tgtctgcag  ggaaggact  ctgcactga  tacaaggct  480
tgtgccaag  agaagtccc  tgggtgaca  aagcctgtg  ctcatccca  gagccccag  540
gtccagaag  gtttgacca  ccgccggtt  tcttgttct  catggacgg  tttagagct  600
agtacttac  aacatggag  accctgctg  caaacatta  caaactgaa  acatgtgga  660
tccattcca  atatatgag  gcagtgtat  ccaccaaaa  ctttccaaa  cattatacc  720
ttgtcacgg  tttgtatcc  gagtcgcac  gcatcattg  caataacat  tatgatgtg  780
acctcaaca  gaatttttc  ctttcttca  tggagaaaa  taaccctgc  tggtggagt  840
ggcagccga  ttggttaac  gcaatgtat  aaggcttaa  agctgcttc  tactactgg  900
caggatcag  tgtggctgt  aatggctcc  tccctaaca  ctacaggaa  tacagcaat  960
ccgtcccat  tgaaagtag  attgctaca  tgttgcaat  gctggacct  cccaaagct  1020
aacgaccca  tttttacac  atatatgtg  aagagcccg  ttctgcggg  cacaagagt  1080
gaccagtca  tgctggagt  attaaagcc  tacagttag  tgatgatgc  tttgggatg  1140
tgatggagg  tttgaaaca  aggaattta  acaactgtg  caacataat  gttctggct  1200
atcatggaa  ggaccagac  tcttgtgac  gagtggaat  catgacaga  tattttcct  1260
aaataaact  ctacatgta  caaggacct  cccctcgaa  caggactcg  aatatacct  1320
aggacttct  tacctttaa  tccgaagag  ttgtcagag  cctcagctg  cgaaaatcc  1380
atcaacact  caaacccta  ttgactccg  atttgccga  acgactgca  tatgccaag  1440
acgtcagga  tgacaaagt  catctaatg  tggatcggc  atggctggc  tacaggaac  1500
aaggagttc  caactgcga  ggcgggaca  acggttaca  caatgaatt  aaaagtatg  1560
aggcaatct  tttggcaca  ggacccagc  ttaaagaga  gactgttat  gaaccattt  1620
aaaacatcg  agtctataa  ctactgtgt  atcttctgc  catccaacc  gcaccaaac  1680
acggttctc  cggtagcct  aatcatctt  tgaaggcac  attttacca  ccgtcgcat  1740
cagaagaat  gtcaaagtc  gctggctgt  gttttacta  tccattgcc  aaggactca  1800
taaactgct  ctgcctcgc  ctgcagact  ctggtcaag  agagcaagt  aaccaaaga  1860
taaatctca  tagaggaga  gtctcggca  cagagaaga  aaatttgcc  tttgggagg  1920
ccagggtga  acagaagaa  aaagaccac  gtctgcttt  ccacaggga  tacgtcagt  1980
ggtttggga  agctatgaa  atgcccatg  ggagttcat  cactgttcc  aagccggga  2040
acacatcat  tcttcctcc  acagttcca  actgtctgc  ggctgatgt  agggttgat  2100
cttcggaga  ccaaaaatg  tccttctat  tagcagacc  gaatatcga  catggcttc  2160
tctatcctc  cgcaatcaa  ggaaataat  agagtcaat  tgatgcttt  attacaagt  2220
atttggtcc  aatgtataa  gaattcaaa  aaatgtggg  ctacttcca  aaagttctc  2280
ttataaaat  cgctataga  agaaatgga  tgaatgtgg  tagtggacc  atatttgat  2340
acaattatg  tggccattt  gatgccccc  atgaaatca  aaactatgt  gctggcacc  2400
atgttcctg  cccgacaca  tactttgtg  tactgacaa  ctgtaaaaa  aaaacccac  2460
cacccgaca  ctgccctgg  tggctggat  tcctgccct  tgtcgtccc  caccggccc  2520
ccaaacccg  ggaaagctg  cctgaaaac  aagcagaag  cctttgggt  gaagagaga  2580
ttaaagcac  catcgcccg  gtccgtgat  tggagctcc  cactggcct  gacttttat  2640
aggaaaaaa  acagcccgt  tctgaaatt  tgcagctga  gacatattt  cccacattc  2700
aaaccatta  ttgaataga  gtgtaaagc  atttgacaa  atga  2744



<210> 1938
<211> 876
<212> PRT
<213> Rattus norvegicus
<308> BAA06333
<400> 1938

Met Asp Ser Arg Leu Ala Leu Ala Thr Glu Glu Pro Ile Lys Lys Asp 
  1               5                  10                  15
Ser Leu Lys Arg Tyr Lys Ile Leu Cys Ala Val Leu Leu Ala Leu Leu 
             20                  25                  30
Val Ile Val Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys Pro 
         35                  40                  45
Glu Glu His Ile Gly Ser Cys Arg Lys Lys Cys Phe Asp Ser Ser His 
     50                  55                  60
Arg Gly Leu Glu Gly Cys Arg Cys Asp Ser Gly Cys Thr Asp Arg Gly 
 65                  70                  75                  80
Asp Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Lys Ser Thr Gln Ile 
                 85                  90                  95
Trp Thr Cys Asn Ser Phe Arg Cys Gly Glu Thr Arg Leu Glu Thr Ala 
             100                105                110
Leu Cys Ser Cys Ala Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys Thr 
         115                120                125
Asp Tyr Lys Ala Val Cys Gln Gly Glu Val Pro Trp Val Thr Glu Ala 
     130                135                140
Cys Ala Ser Ser Gln Glu Pro Gln Cys Pro Glu Gly Phe Asp Gln Pro 
 145                150                155                160
Pro Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu Gln 
                 165                170                175
Thr Trp Ser Thr Leu Leu Pro Asn Ile Asn Lys Leu Lys Thr Cys Gly 
             180                185                190
Leu His Ser Lys Tyr Met Arg Ala Val Tyr Pro Thr Lys Thr Phe Pro 
         195                200                205
Asn His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
     210                215                220
Ile Asp Asn Asn Met Tyr Asp Val Tyr Leu Asn Lys Asn Phe Ser Leu 
 225                230                235                240
Ser Ser Val Glu Lys Ser Asn Pro Ala Trp Trp Ser Gly Gln Pro Ile 
                 245                250                255
Trp Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Ser Tyr Tyr Trp 
             260                265                270
Pro Gly Ser Asp Val Ala Val Asn Gly Ser Phe Pro Asn Ile Tyr Arg 
         275                280                285
Asn Tyr Ser Asn Ser Val Pro Tyr Glu Ser Arg Ile Ala Thr Leu Leu 
     290                295                300
Gln Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Ser Phe Tyr Thr Ile 
 305                310                315                320
Tyr Val Glu Glu Pro Asp Ser Ala Gly His Lys Ser Gly Pro Val Ser 
                 325                330                335
Ala Gly Val Ile Lys Ala Leu Gln Leu Val Asp Asp Ala Phe Gly Met 
             340                345                350
Leu Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn Ile 
         355                360                365
Ile Val Leu Ala Asp His Gly Met Asp Gln Thr Ser Cys Asp Arg Val 
     370                375                380
Glu Tyr Met Thr Asp Tyr Phe Pro Glu Ile Asn Phe Tyr Met Tyr Gln 
 385                390                395                400
Gly Pro Ala Pro Arg Ile Arg Thr Arg Asn Ile Pro Gln Asp Phe Phe 
                 405                410                415
Thr Phe Asn Ser Glu Glu Ile Val Arg Asp Leu Ser Cys Arg Lys Ser 
             420                425                430
Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys Arg Leu 
         435                440                445
His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Met Val Asp 
     450                455                460
Arg Gln Trp Leu Ala Tyr Arg Asn Lys Gly Val Pro Asn Cys Glu Gly 
 465                470                475                480
Gly Thr His Gly Tyr Asn Asn Glu Phe Lys Ser Met Glu Ala Ile Phe 
                 485                490                495
Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Val Ile Glu Pro Phe 
             500                505                510
Glu Asn Ile Glu Val Tyr Asn Leu Leu Cys Asp Leu Leu His Ile Gln 
         515                520                525
Pro Ala Pro Asn Asn Gly Ser His Gly Ser Leu Asn His Leu Leu Lys 
     530                535                540
Ala Pro Phe Tyr Gln Pro Ser His Ala Glu Glu Leu Ser Lys Ser Ala 
 545                550                555                560
Gly Cys Gly Phe Thr Thr Pro Leu Pro Lys Asp Ser Leu Asn Cys Ser 
                 565                570                575
Cys Leu Ala Leu Gln Thr Ser Gly Gln Glu Glu Gln Val Asn Gln Arg 
             580                585                590
Leu Asn Leu Asn Arg Gly Glu Val Ser Ala Thr Glu Lys Thr Asn Leu 
         595                600                605
Pro Phe Gly Arg Pro Arg Val Ile Gln Lys Asn Lys Asp His Cys Leu 
     610                615                620
Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met Lys Met 
 625                630                635                640
Pro Met Trp Ser Ser Tyr Thr Val Pro Lys Pro Gly Asp Thr Ser Ser 
                 645                650                655
Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg Val Asp 
             660                665                670
Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Gln Asn Ile 
         675                680                685
Asp His Gly Phe Leu Tyr Pro Pro Ala Ile Lys Gly Asn Asn Glu Ser 
     690                695                700
Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr Lys Glu 
 705                710                715                720
Phe Lys Lys Met Trp Asp Tyr Phe His Lys Val Leu Leu Ile Lys Tyr 
                 725                730                735
Ala Ile Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile Phe Asp 
             740                745                750
Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr Asn Tyr 
         755                760                765
Val Ala Gly Thr Asp Val Pro Val Pro Thr His Tyr Phe Val Val Leu 
     770                775                780
Thr Ser Cys Lys Asn Lys Thr His Thr Pro Asp Ser Cys Pro Gly Trp 
 785                790                795                800
Leu Asp Val Leu Pro Phe Val Val Pro His Arg Pro Thr Lys Pro Val 
                 805                810                815
Glu Ser Cys Pro Glu Asn Lys Ala Glu Asp Leu Trp Val Glu Glu Arg 
             820                825                830
Phe Lys Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr Gly 
         835                840                845
Leu Asp Phe Tyr Gln Glu Lys Thr Gln Pro Val Ser Glu Ile Leu Gln 
     850                855                860
Leu Lys Thr Tyr Leu Pro Thr Phe Glu Thr Ile Ile 
 865                870                875



<210> 1939
<211> 3858
<212> DNA
<213> Homo sapiens
<308> AF005632
<400> 1939

ctactttat  ctgataaaa  aggtctatg  agctaccag  acaatggaa  ctacgttga  60
tttagcaac  gaacaacct  ttaagaaga  cactcttaa  aaatataaa  tagcttgca  120
tgttcttct  gctttgctg  tgatcatgt  acttggatt  ggcctgggg  ttggactca  180
gaaactgga  aagcaaggc  gctgcagga  gaagtgctt  gatgcatca  ttagaggac  240
ggagaactg  cggtgtgat  tggcatgta  agaccgagg  gattgctgc  gggattttg  300
agacacctg  gtggaatca  ctcgaatat  gatgtgcaa  aaatttcgt  gtggagaga  360
cagattaga  gccagcctt  gctcttgtt  agatgactg  ttgcagaag  aagattgct  420
tgctgacta  aagagtgtt  gccaaggag  aacctcatg  ctggaagaa  actgtgaca  480
agcccagca  tctcagtgc  cagaagggt  tgacctgcc  ccagttatc  tgttttcta  540
ggatggatt  agagctgaa  atttataca  atgggatac  ttaatgcca  atatcaata  600
actgaaaac  tgtggaatt  attcaaaat  catgagagc  atgtatcct  ccaaaacct  660
cccaaatca  tacaccatt  tcacgggct  gtatccaga  tcacatggc  tcattgaca  720
taatatgta  gatgtaaat  tcaacaaga  tttttcact  tcttcaaag  aacaaaata  780
tccagcctg  tggcatggg  aaccaatgt  gctgacagc  atgtatcaa  gtttaaaag  840
cgctaccta  ttttggccc  gatcagaag  ggctataaa  ggctccttt  cttccatat  900
catgcctta  aacggaagt  tcccatttg  agagaggat  tctacactg  taaaatggc  960
ggacctgcc  aaagctgaa  gacccaggt  ttataccat  tattttgaa  aacctgatt  1020
ctctggaca  gcaggtgga  cagtcagtg  cagagtaat  aaagcctta  aggtagtag  1080
tcatgcttt  gggatgttg  tggaaggcc  gaagcagcg  aatttgcac  actgtgtca  1140
tatcatcct  ctggctgac  atggaatgg  ccagactta  tgtaacaag  tggaataca  1200
gactgatta  tttcccaga  taaacttct  ctacatgta  gaagggcct  ccccccgca  1260
ccgagctca  aatatacct  atgactttt  tagttttaa  tctgaggaa  ttgttagaa  1320
cctcagttg  cgaaaacct  atcagcatt  caagcccta  ttgactcct  atttgccaa  1380
gcgactgca  tatgccaag  acgtcagaa  cgacaaagt  catctcttt  tggatcaac  1440
gtggctggc  gttaggagt  aatcaaata  aaattgtgg  ggaggcaac  atggttata  1500
caatgagtt  aggagcatg  aggctatct  tctggcaca  ggacccagt  ttaaagaga  1560
gactgaagt  gaaccattt  aaaatattg  agtctataa  ctaatgtgt  atcttctac  1620
cattcaacc  gcaccaaac  atggaaccc  tggtagttt  aaccatctt  tgaaggtgc  1680
tttttatga  ccatcccat  cagaggagg  gtcaaagtt  tctgtttgt  gctttgcta  1740
tccattgcc  acagagtct  ttgactgtt  ctgccctca  ctacaaaat  gtactcagc  1800
ggaacaagt  aatcagatg  taaatctca  ccaagaaga  ataacagca  cagtgaaag  1860
aaatttgcc  tttgggagg  ctagggtac  gcagaagaa  gtggaccac  gtctccttt  1920
ccacaggga  tatgtcagt  gatttggaa  agctatgag  atgcccatg  ggagttcat  1980
cacagtccc  cagttggga  acacatcgc  tctgcctcc  actgtccca  actgtctgc  2040
ggctgatgt  agggttcct  cttctgaga  ccaaaaatg  tccttctat  tagcagaca  2100
gaatatcac  cacggcttc  tctatcctc  tgccagcaa  agaacatca  atagccaat  2160
tgatgcttt  attactagc  atttggtac  tatgtatga  gaattcaga  aaatgtggg  2220
ctacttcca  agtgttctt  ttataaaac  tgccacaga  agaaatgga  taaatgtgg  2280
tagtggacc  atatttgat  ataattatg  tggccattt  gatgctcca  atgaaatta  2340
caaacattt  gccaacact  atgttccca  cccaacaca  tactttgtg  tgctgacca  2400
ttgtaaaaa  aagagccac  caccggaaa  ctgccctgg  tggctggat  tcctaccct  2460
tatcatccc  caccgacct  ccaacgtgg  gagctgtcc  gaaggtaaa  cagaagctc  2520
ttgggttga  gaaagattt  cagctcaca  tgcccgggt  cgtgatgta  aacttctca  2580
tgggcttga  ttctatcag  ataaagtgc  gcctgtctc  gaaattttg  aactaaaga  2640
atatttacc  acatttgaa  ccactattt  acttaataa  gtctactta  tatataatt  2700
actgtataa  gtaattttg  caaaatata  gtgattttt  ctggagaat  gtaaaataa  2760
gttttctat  tttccttaa  aaaaaaacc  gaattccgg  cttgggagg  tgaggcagg  2820
gactcgctt  aacccggga  gcagaggtt  cagtgagcc  agattgcgc  attgcactc  2880
agagcctgg  tgacagagc  agactacat  tcaaaaaat  aataaataa  ataaaagta  2940
caataaaaa  aaaaagaac  gcagagaga  tgagcaagg  gaaatgtca  aaactattg  3000
aaaatactg  tacactggg  tggctctcc  agaagatac  ggaatctct  cagccattt  3060
cttttcaga  gtagaaacc  gcaaaccac  tctaagcgg  gaacatacg  ttctttatt  3120
agtagctct  gggaaggaa  gaataaaag  tgatagctc  ctgattggg  aaaaatgca  3180
aattaataa  gaatgaaga  gaaagaaag  atgcttatg  tgtaacaca  aaaaaattc  3240
caaacgttg  tggaaggaa  acagtatag  aaacattac  ttaactaaa  gctggaaaa  3300
ttttcagtt  ggatgcgac  gacaaaaag  acgggattt  caggcataa  gttggcgtg  3360
gctacagag  gcaccatgt  gctcagtgg  agacccttc  agattcaaa  ttccatttg  3420
cagagcaaa  gcacttcgc  aggagaagg  tttaaatta  gggtccaaa  gccaagtgg  3480
aaagcgagc  atttgcagc  taactgctt  tcctagaca  ggctgagtg  gcaaaatac  3540
acagtacac  cagtgacta  tagccactg  cagaaacag  ctgaacagc  ctgggagac  3600
agggaaggc  ggtggtggg  gttgttcat  gagagaaag  agagtttta  aaccagcac  3660
tccactgga  atgctgggc  accagaccc  tcccagtca  taaagtctg  tgcctcatt  3720
gatctcagc  tcatcatga  cctggagag  ccctgatac  atctgccag  ccccgacag  3780
ttaggcact  cttgccatc  acctgaccc  ccgagtggt  ctccaggct  cctgcccca  3840
ccattcagg  cggaattc  3858



<210> 1940
<211> 875
<212> PRT
<213> Homo sapiens
<308> AAC51813
<400> 1940

Met Glu Ser Thr Leu Thr Leu Ala Thr Glu Gln Pro Val Lys Lys Asn 
  1               5                  10                  15
Thr Leu Lys Lys Tyr Lys Ile Ala Cys Ile Val Leu Leu Ala Leu Leu 
             20                  25                  30
Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys Leu 
         35                  40                  45
Glu Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala Ser Phe Arg 
     50                  55                  60
Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp Arg Gly Asp 
 65                  70                  75                  80
Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr Arg Ile Trp 
                 85                  90                  95
Met Cys Asn Lys Phe Arg Cys Gly Glu Thr Arg Leu Glu Ala Ser Leu 
             100                105                110
Cys Ser Cys Ser Asp Asp Cys Leu Gln Lys Lys Asp Cys Cys Ala Asp 
         115                120                125
Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu Asn Cys 
     130                135                140
Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu Pro Pro 
 145                150                155                160
Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu Tyr Thr 
                 165                170                175
Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys Gly Ile 
             180                185                190
His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe Pro Asn 
         195                200                205
His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile 
     210                215                220
Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser Leu Ser 
 225                230                235                240
Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro Met Trp 
                 245                250                255
Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe Trp Pro 
             260                265                270
Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr Met Pro 
         275                280                285
Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu Leu Lys 
     290                295                300
Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr Met Tyr 
 305                310                315                320
Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val Ser Ala 
                 325                330                335
Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe Gly Met Leu 
             340                345                350
Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn Ile Ile 
         355                360                365
Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys Met Glu 
     370                375                380
Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met Tyr Glu 
 385                390                395                400
Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His Asp Phe Phe 
                 405                410                415
Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg Lys Pro 
             420                425                430
Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys Arg Leu 
         435                440                445
His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Phe Val Asp 
     450                455                460
Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys Gly Gly 
 465                470                475                480
Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala Ile Phe 
                 485                490                495
Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu Pro Phe 
             500                505                510
Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg Ile Gln 
         515                520                525
Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys 
     530                535                540
Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys Phe Ser 
 545                550                555                560
Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp Cys Phe 
                 565                570                575
Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn Gln Met 
             580                585                590
Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val Asn Leu 
         595                600                605
Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp His Cys Leu 
     610                615                620
Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met Arg Met 
 625                630                635                640
Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr Ser Pro 
                 645                650                655
Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg Val Pro 
             660                665                670
Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys Asn Ile 
         675                680                685
Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser Asp Ser 
     690                695                700
Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr Glu Glu 
 705                710                715                720
Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile Lys His 
                 725                730                735
Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile Phe Asp 
             740                745                750
Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr Lys His 
         755                760                765
Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val Val Leu 
     770                775                780
Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro Gly Trp 
 785                790                795                800
Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn Val Glu 
                 805                810                815
Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu Arg Phe 
             820                825                830
Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr Gly Leu 
         835                840                845
Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu Gln Leu 
     850                855                860
Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile 
 865                870                875



<210> 1941
<211> 2744
<212> DNA
<213> Rattus norvegicus
<308> D30649
<400> 1941

tgaggacag  tcctttttc  ctccctaga  gaaagaaag  gccttattt  ctggctaaa  60
aggtttaca  agctacagg  acaatggat  ccaggctag  tttagccac  gaggagccc  120
ttaagaaag  cagcctgaa  agatataag  tcctttgtg  ggttcttct  gctttgctg  180
tgatcgtgt  gcttggatt  ggcctgggc  tgggactca  gaaacctga  gagcatata  240
gcagctgca  gaaaaaatg  tttgattcg  cacacagag  actggaggg  tgccgctgt  300
actccggat  cacagaccg  ggagactgc  gctgggact  tgaagatac  tgtgtgaaa  360
caactcaaa  ctggacgtg  aattcgttc  gctgtgggg  gaccagact  gagacagcc  420
tctgttcct  tgcggatga  tgtctgcag  ggaaggact  ctgcactga  tacaaggct  480
tgtgccaag  agaagtccc  tgggtgaca  aagcctgtg  ctcatccca  gagccccag  540
gtccagaag  gtttgacca  ccgccggtt  tcttgttct  catggacgg  tttagagct  600
agtacttac  aacatggag  accctgctg  caaacatta  caaactgaa  acatgtgga  660
tccattcca  atatatgag  gcagtgtat  ccaccaaaa  ctttccaaa  cattatacc  720
ttgtcacgg  tttgtatcc  gagtcgcac  gcatcattg  caataacat  tatgatgtg  780
acctcaaca  gaatttttc  ctttcttca  tggagaaaa  taaccctgc  tggtggagt  840
ggcagccga  ttggttaac  gcaatgtat  aaggcttaa  agctgcttc  tactactgg  900
caggatcag  tgtggctgt  aatggctcc  tccctaaca  ctacaggaa  tacagcaat  960
ccgtcccat  tgaaagtag  attgctaca  tgttgcaat  gctggacct  cccaaagct  1020
aacgaccca  tttttacac  atatatgtg  aagagcccg  ttctgcggg  cacaagagt  1080
gaccagtca  tgctggagt  attaaagcc  tacagttag  tgatgatgc  tttgggatg  1140
tgatggagg  tttgaaaca  aggaattta  acaactgtg  caacataat  gttctggct  1200
atcatggaa  ggaccagac  tcttgtgac  gagtggaat  catgacaga  tattttcct  1260
aaataaact  ctacatgta  caaggacct  cccctcgaa  caggactcg  aatatacct  1320
aggacttct  tacctttaa  tccgaagag  ttgtcagag  cctcagctg  cgaaaatcc  1380
atcaacact  caaacccta  ttgactccg  atttgccga  acgactgca  tatgccaag  1440
acgtcagga  tgacaaagt  catctaatg  tggatcggc  atggctggc  tacaggaac  1500
aaggagttc  caactgcga  ggcgggaca  acggttaca  caatgaatt  aaaagtatg  1560
aggcaatct  tttggcaca  ggacccagc  ttaaagaga  gactgttat  gaaccattt  1620
aaaacatcg  agtctataa  ctactgtgt  atcttctgc  catccaacc  gcaccaaac  1680
acggttctc  cggtagcct  aatcatctt  tgaaggcac  attttacca  ccgtcgcat  1740
cagaagaat  gtcaaagtc  gctggctgt  gttttacta  tccattgcc  aaggactca  1800
taaactgct  ctgcctcgc  ctgcagact  ctggtcaag  agagcaagt  aaccaaaga  1860
taaatctca  tagaggaga  gtctcggca  cagagaaga  aaatttgcc  tttgggagg  1920
ccagggtga  acagaagaa  aaagaccac  gtctgcttt  ccacaggga  tacgtcagt  1980
ggtttggga  agctatgaa  atgcccatg  ggagttcat  cactgttcc  aagccggga  2040
acacatcat  tcttcctcc  acagttcca  actgtctgc  ggctgatgt  agggttgat  2100
cttcggaga  ccaaaaatg  tccttctat  tagcagacc  gaatatcga  catggcttc  2160
tctatcctc  cgcaatcaa  ggaaataat  agagtcaat  tgatgcttt  attacaagt  2220
atttggtcc  aatgtataa  gaattcaaa  aaatgtggg  ctacttcca  aaagttctc  2280
ttataaaat  cgctataga  agaaatgga  tgaatgtgg  tagtggacc  atatttgat  2340
acaattatg  tggccattt  gatgccccc  atgaaatca  aaactatgt  gctggcacc  2400
atgttcctg  cccgacaca  tactttgtg  tactgacaa  ctgtaaaaa  aaaacccac  2460
cacccgaca  ctgccctgg  tggctggat  tcctgccct  tgtcgtccc  caccggccc  2520
ccaaacccg  ggaaagctg  cctgaaaac  aagcagaag  cctttgggt  gaagagaga  2580
ttaaagcac  catcgcccg  gtccgtgat  tggagctcc  cactggcct  gacttttat  2640
aggaaaaaa  acagcccgt  tctgaaatt  tgcagctga  gacatattt  cccacattc  2700
aaaccatta  ttgaataga  gtgtaaagc  atttgacaa  atga  2744



<210> 1942
<211> 876
<212> PRT
<213> Rattus norvegicus
<308> BAA06333
<400> 1942

Met Asp Ser Arg Leu Ala Leu Ala Thr Glu Glu Pro Ile Lys Lys Asp 
  1               5                  10                  15
Ser Leu Lys Arg Tyr Lys Ile Leu Cys Ala Val Leu Leu Ala Leu Leu 
             20                  25                  30
Val Ile Val Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys Pro 
         35                  40                  45
Glu Glu His Ile Gly Ser Cys Arg Lys Lys Cys Phe Asp Ser Ser His 
     50                  55                  60
Arg Gly Leu Glu Gly Cys Arg Cys Asp Ser Gly Cys Thr Asp Arg Gly 
 65                  70                  75                  80
Asp Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Lys Ser Thr Gln Ile 
                 85                  90                  95
Trp Thr Cys Asn Ser Phe Arg Cys Gly Glu Thr Arg Leu Glu Thr Ala 
             100                105                110
Leu Cys Ser Cys Ala Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys Thr 
         115                120                125
Asp Tyr Lys Ala Val Cys Gln Gly Glu Val Pro Trp Val Thr Glu Ala 
     130                135                140
Cys Ala Ser Ser Gln Glu Pro Gln Cys Pro Glu Gly Phe Asp Gln Pro 
 145                150                155                160
Pro Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu Gln 
                 165                170                175
Thr Trp Ser Thr Leu Leu Pro Asn Ile Asn Lys Leu Lys Thr Cys Gly 
             180                185                190
Leu His Ser Lys Tyr Met Arg Ala Val Tyr Pro Thr Lys Thr Phe Pro 
         195                200                205
Asn His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
     210                215                220
Ile Asp Asn Asn Met Tyr Asp Val Tyr Leu Asn Lys Asn Phe Ser Leu 
 225                230                235                240
Ser Ser Val Glu Lys Ser Asn Pro Ala Trp Trp Ser Gly Gln Pro Ile 
                 245                250                255
Trp Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Ser Tyr Tyr Trp 
             260                265                270
Pro Gly Ser Asp Val Ala Val Asn Gly Ser Phe Pro Asn Ile Tyr Arg 
         275                280                285
Asn Tyr Ser Asn Ser Val Pro Tyr Glu Ser Arg Ile Ala Thr Leu Leu 
     290                295                300
Gln Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Ser Phe Tyr Thr Ile 
 305                310                315                320
Tyr Val Glu Glu Pro Asp Ser Ala Gly His Lys Ser Gly Pro Val Ser 
                 325                330                335
Ala Gly Val Ile Lys Ala Leu Gln Leu Val Asp Asp Ala Phe Gly Met 
             340                345                350
Leu Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn Ile 
         355                360                365
Ile Val Leu Ala Asp His Gly Met Asp Gln Thr Ser Cys Asp Arg Val 
     370                375                380
Glu Tyr Met Thr Asp Tyr Phe Pro Glu Ile Asn Phe Tyr Met Tyr Gln 
 385                390                395                400
Gly Pro Ala Pro Arg Ile Arg Thr Arg Asn Ile Pro Gln Asp Phe Phe 
                 405                410                415
Thr Phe Asn Ser Glu Glu Ile Val Arg Asp Leu Ser Cys Arg Lys Ser 
             420                425                430
Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys Arg Leu 
         435                440                445
His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Met Val Asp 
     450                455                460
Arg Gln Trp Leu Ala Tyr Arg Asn Lys Gly Val Pro Asn Cys Glu Gly 
 465                470                475                480
Gly Thr His Gly Tyr Asn Asn Glu Phe Lys Ser Met Glu Ala Ile Phe 
                 485                490                495
Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Val Ile Glu Pro Phe 
             500                505                510
Glu Asn Ile Glu Val Tyr Asn Leu Leu Cys Asp Leu Leu His Ile Gln 
         515                520                525
Pro Ala Pro Asn Asn Gly Ser His Gly Ser Leu Asn His Leu Leu Lys 
     530                535                540
Ala Pro Phe Tyr Gln Pro Ser His Ala Glu Glu Leu Ser Lys Ser Ala 
 545                550                555                560
Gly Cys Gly Phe Thr Thr Pro Leu Pro Lys Asp Ser Leu Asn Cys Ser 
                 565                570                575
Cys Leu Ala Leu Gln Thr Ser Gly Gln Glu Glu Gln Val Asn Gln Arg 
             580                585                590
Leu Asn Leu Asn Arg Gly Glu Val Ser Ala Thr Glu Lys Thr Asn Leu 
         595                600                605
Pro Phe Gly Arg Pro Arg Val Ile Gln Lys Asn Lys Asp His Cys Leu 
     610                615                620
Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met Lys Met 
 625                630                635                640
Pro Met Trp Ser Ser Tyr Thr Val Pro Lys Pro Gly Asp Thr Ser Ser 
                 645                650                655
Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg Val Asp 
             660                665                670
Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Gln Asn Ile 
         675                680                685
Asp His Gly Phe Leu Tyr Pro Pro Ala Ile Lys Gly Asn Asn Glu Ser 
     690                695                700
Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr Lys Glu 
 705                710                715                720
Phe Lys Lys Met Trp Asp Tyr Phe His Lys Val Leu Leu Ile Lys Tyr 
                 725                730                735
Ala Ile Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile Phe Asp 
             740                745                750
Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr Asn Tyr 
         755                760                765
Val Ala Gly Thr Asp Val Pro Val Pro Thr His Tyr Phe Val Val Leu 
     770                775                780
Thr Ser Cys Lys Asn Lys Thr His Thr Pro Asp Ser Cys Pro Gly Trp 
 785                790                795                800
Leu Asp Val Leu Pro Phe Val Val Pro His Arg Pro Thr Lys Pro Val 
                 805                810                815
Glu Ser Cys Pro Glu Asn Lys Ala Glu Asp Leu Trp Val Glu Glu Arg 
             820                825                830
Phe Lys Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr Gly 
         835                840                845
Leu Asp Phe Tyr Gln Glu Lys Thr Gln Pro Val Ser Glu Ile Leu Gln 
     850                855                860
Leu Lys Thr Tyr Leu Pro Thr Phe Glu Thr Ile Ile 
 865                870                875



<210> 1943
<211> 3858
<212> DNA
<213> Homo sapiens
<308> AF005632
<400> 1943

ctactttat  ctgataaaa  aggtctatg  agctaccag  acaatggaa  ctacgttga  60
tttagcaac  gaacaacct  ttaagaaga  cactcttaa  aaatataaa  tagcttgca  120
tgttcttct  gctttgctg  tgatcatgt  acttggatt  ggcctgggg  ttggactca  180
gaaactgga  aagcaaggc  gctgcagga  gaagtgctt  gatgcatca  ttagaggac  240
ggagaactg  cggtgtgat  tggcatgta  agaccgagg  gattgctgc  gggattttg  300
agacacctg  gtggaatca  ctcgaatat  gatgtgcaa  aaatttcgt  gtggagaga  360
cagattaga  gccagcctt  gctcttgtt  agatgactg  ttgcagaag  aagattgct  420
tgctgacta  aagagtgtt  gccaaggag  aacctcatg  ctggaagaa  actgtgaca  480
agcccagca  tctcagtgc  cagaagggt  tgacctgcc  ccagttatc  tgttttcta  540
ggatggatt  agagctgaa  atttataca  atgggatac  ttaatgcca  atatcaata  600
actgaaaac  tgtggaatt  attcaaaat  catgagagc  atgtatcct  ccaaaacct  660
cccaaatca  tacaccatt  tcacgggct  gtatccaga  tcacatggc  tcattgaca  720
taatatgta  gatgtaaat  tcaacaaga  tttttcact  tcttcaaag  aacaaaata  780
tccagcctg  tggcatggg  aaccaatgt  gctgacagc  atgtatcaa  gtttaaaag  840
cgctaccta  ttttggccc  gatcagaag  ggctataaa  ggctccttt  cttccatat  900
catgcctta  aacggaagt  tcccatttg  agagaggat  tctacactg  taaaatggc  960
ggacctgcc  aaagctgaa  gacccaggt  ttataccat  tattttgaa  aacctgatt  1020
ctctggaca  gcaggtgga  cagtcagtg  cagagtaat  aaagcctta  aggtagtag  1080
tcatgcttt  gggatgttg  tggaaggcc  gaagcagcg  aatttgcac  actgtgtca  1140
tatcatcct  ctggctgac  atggaatgg  ccagactta  tgtaacaag  tggaataca  1200
gactgatta  tttcccaga  taaacttct  ctacatgta  gaagggcct  ccccccgca  1260
ccgagctca  aatatacct  atgactttt  tagttttaa  tctgaggaa  ttgttagaa  1320
cctcagttg  cgaaaacct  atcagcatt  caagcccta  ttgactcct  atttgccaa  1380
gcgactgca  tatgccaag  acgtcagaa  cgacaaagt  catctcttt  tggatcaac  1440
gtggctggc  gttaggagt  aatcaaata  aaattgtgg  ggaggcaac  atggttata  1500
caatgagtt  aggagcatg  aggctatct  tctggcaca  ggacccagt  ttaaagaga  1560
gactgaagt  gaaccattt  aaaatattg  agtctataa  ctaatgtgt  atcttctac  1620
cattcaacc  gcaccaaac  atggaaccc  tggtagttt  aaccatctt  tgaaggtgc  1680
tttttatga  ccatcccat  cagaggagg  gtcaaagtt  tctgtttgt  gctttgcta  1740
tccattgcc  acagagtct  ttgactgtt  ctgccctca  ctacaaaat  gtactcagc  1800
ggaacaagt  aatcagatg  taaatctca  ccaagaaga  ataacagca  cagtgaaag  1860
aaatttgcc  tttgggagg  ctagggtac  gcagaagaa  gtggaccac  gtctccttt  1920
ccacaggga  tatgtcagt  gatttggaa  agctatgag  atgcccatg  ggagttcat  1980
cacagtccc  cagttggga  acacatcgc  tctgcctcc  actgtccca  actgtctgc  2040
ggctgatgt  agggttcct  cttctgaga  ccaaaaatg  tccttctat  tagcagaca  2100
gaatatcac  cacggcttc  tctatcctc  tgccagcaa  agaacatca  atagccaat  2160
tgatgcttt  attactagc  atttggtac  tatgtatga  gaattcaga  aaatgtggg  2220
ctacttcca  agtgttctt  ttataaaac  tgccacaga  agaaatgga  taaatgtgg  2280
tagtggacc  atatttgat  ataattatg  tggccattt  gatgctcca  atgaaatta  2340
caaacattt  gccaacact  atgttccca  cccaacaca  tactttgtg  tgctgacca  2400
ttgtaaaaa  aagagccac  caccggaaa  ctgccctgg  tggctggat  tcctaccct  2460
tatcatccc  caccgacct  ccaacgtgg  gagctgtcc  gaaggtaaa  cagaagctc  2520
ttgggttga  gaaagattt  cagctcaca  tgcccgggt  cgtgatgta  aacttctca  2580
tgggcttga  ttctatcag  ataaagtgc  gcctgtctc  gaaattttg  aactaaaga  2640
atatttacc  acatttgaa  ccactattt  acttaataa  gtctactta  tatataatt  2700
actgtataa  gtaattttg  caaaatata  gtgattttt  ctggagaat  gtaaaataa  2760
gttttctat  tttccttaa  aaaaaaacc  gaattccgg  cttgggagg  tgaggcagg  2820
gactcgctt  aacccggga  gcagaggtt  cagtgagcc  agattgcgc  attgcactc  2880
agagcctgg  tgacagagc  agactacat  tcaaaaaat  aataaataa  ataaaagta  2940
caataaaaa  aaaaagaac  gcagagaga  tgagcaagg  gaaatgtca  aaactattg  3000
aaaatactg  tacactggg  tggctctcc  agaagatac  ggaatctct  cagccattt  3060
cttttcaga  gtagaaacc  gcaaaccac  tctaagcgg  gaacatacg  ttctttatt  3120
agtagctct  gggaaggaa  gaataaaag  tgatagctc  ctgattggg  aaaaatgca  3180
aattaataa  gaatgaaga  gaaagaaag  atgcttatg  tgtaacaca  aaaaaattc  3240
caaacgttg  tggaaggaa  acagtatag  aaacattac  ttaactaaa  gctggaaaa  3300
ttttcagtt  ggatgcgac  gacaaaaag  acgggattt  caggcataa  gttggcgtg  3360
gctacagag  gcaccatgt  gctcagtgg  agacccttc  agattcaaa  ttccatttg  3420
cagagcaaa  gcacttcgc  aggagaagg  tttaaatta  gggtccaaa  gccaagtgg  3480
aaagcgagc  atttgcagc  taactgctt  tcctagaca  ggctgagtg  gcaaaatac  3540
acagtacac  cagtgacta  tagccactg  cagaaacag  ctgaacagc  ctgggagac  3600
agggaaggc  ggtggtggg  gttgttcat  gagagaaag  agagtttta  aaccagcac  3660
tccactgga  atgctgggc  accagaccc  tcccagtca  taaagtctg  tgcctcatt  3720
gatctcagc  tcatcatga  cctggagag  ccctgatac  atctgccag  ccccgacag  3780
ttaggcact  cttgccatc  acctgaccc  ccgagtggt  ctccaggct  cctgcccca  3840
ccattcagg  cggaattc  3858



<210> 1944
<211> 875
<212> PRT
<213> Homo sapiens
<308> AAC51813
<400> 1944

Met Glu Ser Thr Leu Thr Leu Ala Thr Glu Gln Pro Val Lys Lys Asn 
  1               5                  10                  15
Thr Leu Lys Lys Tyr Lys Ile Ala Cys Ile Val Leu Leu Ala Leu Leu 
             20                  25                  30
Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys Leu 
         35                  40                  45
Glu Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala Ser Phe Arg 
     50                  55                  60
Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp Arg Gly Asp 
 65                  70                  75                  80
Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr Arg Ile Trp 
                 85                  90                  95
Met Cys Asn Lys Phe Arg Cys Gly Glu Thr Arg Leu Glu Ala Ser Leu 
             100                105                110
Cys Ser Cys Ser Asp Asp Cys Leu Gln Lys Lys Asp Cys Cys Ala Asp 
         115                120                125
Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu Asn Cys 
     130                135                140
Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu Pro Pro 
 145                150                155                160
Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu Tyr Thr 
                 165                170                175
Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys Gly Ile 
             180                185                190
His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe Pro Asn 
         195                200                205
His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile 
     210                215                220
Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser Leu Ser 
 225                230                235                240
Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro Met Trp 
                 245                250                255
Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe Trp Pro 
             260                265                270
Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr Met Pro 
         275                280                285
Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu Leu Lys 
     290                295                300
Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr Met Tyr 
 305                310                315                320
Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val Ser Ala 
                 325                330                335
Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe Gly Met Leu 
             340                345                350
Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn Ile Ile 
         355                360                365
Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys Met Glu 
     370                375                380
Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met Tyr Glu 
 385                390                395                400
Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His Asp Phe Phe 
                 405                410                415
Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg Lys Pro 
             420                425                430
Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys Arg Leu 
         435                440                445
His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Phe Val Asp 
     450                455                460
Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys Gly Gly 
 465                470                475                480
Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala Ile Phe 
                 485                490                495
Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu Pro Phe 
             500                505                510
Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg Ile Gln 
         515                520                525
Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys 
     530                535                540
Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys Phe Ser 
 545                550                555                560
Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp Cys Phe 
                 565                570                575
Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn Gln Met 
             580                585                590
Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val Asn Leu 
         595                600                605
Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp His Cys Leu 
     610                615                620
Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met Arg Met 
 625                630                635                640
Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr Ser Pro 
                 645                650                655
Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg Val Pro 
             660                665                670
Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys Asn Ile 
         675                680                685
Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser Asp Ser 
     690                695                700
Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr Glu Glu 
 705                710                715                720
Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile Lys His 
                 725                730                735
Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile Phe Asp 
             740                745                750
Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr Lys His 
         755                760                765
Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val Val Leu 
     770                775                780
Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro Gly Trp 
 785                790                795                800
Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn Val Glu 
                 805                810                815
Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu Arg Phe 
             820                825                830
Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr Gly Leu 
         835                840                845
Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu Gln Leu 
     850                855                860
Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile 
 865                870                875



<210> 1945
<211> 2996
<212> DNA
<213> Rattus norvegicus
<308> D30734
<400> 1945

ccgccttga  gggctacgc  ggcggtagg  ctgcggtag  ggccgggcg  caccatggc  60
gcggcagcg  ctgctgcgg  ggctttaac  gaggcgccg  ccgtcccgg  caccgcaga  120
cccgagacg  gagacgagg  cagtcgtga  gtccgagtg  tgcagagcc  gcgcggcag  180
atctatgaa  caaaaaatt  attgccata  cttggaccc  acaaaatgc  ggattgttt  240
tgcactata  atttggacc  ggaagaagt  tatcgcacc  aggttgttg  aaagtcttt  300
agtccatat  tcagtgaag  attttattt  gagattcca  gaactttcc  gtatttgtc  360
ttttatgtt  atgataaaa  tgttttaca  agagatctt  gtataggaa  agtagccat  420
aaaaaagaa  acttgtgca  tcatagtgg  aaagaaact  ggttttcat  gcagcctat  480
gactcaaat  cagaagttc  gggaaaagt  caccttgaa  taaaactga  tgaattgat  540
acagaaaat  gaactgtgt  ccagcagct  gttgtacac  tcaaggcat  ccacgggtt  600
cctcttatc  atggacaaa  ctgtgatcc  tacgcaaca  tttccctcg  gggcccttc  660
aggaatgac  aaaagaaga  aaaagtaaa  aagaaaaca  gcaatccac  gttcaatga  720
gtcttctac  ttgaggtaa  cagatccag  agttacacc  ggaagtccc  gttccaggt  780
gaggaggaa  acattgaga  gctggaaat  aggattgac  tgtggaata  tgaaaacct  840
gttcaagat  ttttcctgg  ggagattaa  gttcctgtc  atgtgttaa  aaatgattc  900
tctcatcaa  cctggtact  gctacaacc  agagacaat  gaaacaagt  gtctaaacc  960
gatgacctg  gatccctcc  gttaactct  tgttacaca  aagactacg  gctcccatc  1020
gagtactat  gacccttga  agctttgct  ctaaaatca  cagatgttc  gccagtatc  1080
gcctcagct  cttatattt  gggtgaaat  tgtcgagac  agaaggatg  cgttttgcc  1140
ctcgtacga  tgttgctgc  tcacaataa  cttgttccc  ttatcactg  ggtggctga  1200
ctggacttg  aggatactc  agatgccaa  gcaatattt  gaggaaact  cctggctac  1260
cagtgtctg  ctgagatga  gaagatagt  ggagggcac  acctgaaag  cacattgaa  1320
cctgttctg  atgagatat  tgagtcctc  aaatcctgt  aaatagatc  tgttaagtt  1380
aaagaggga  ataatgtgg  gagtaataa  gagaatctg  actactatg  ggacaaagt  1440
ttcagtgcg  tcgtaggat  gagtgtgag  tgtcccact  tgatgtgtg  tatttttta  1500
tctctgaga  agatggctg  taagagatt  cctaataac  ctcatgttc  gtactctgc  1560
gtgagcagc  ttgtgtttc  tcgtttctt  gctgtagcg  ttctgtcac  tcatgcttt  1620
catttgcga  ctcattatc  agatacaca  acagttagg  ctttaactc  catctcaaa  1680
accattcag  ttattggaa  ctggggatg  caatccaga  gaaagtcac  gttcaaaaa  1740
tcagtcatg  gtgaatttc  caaaatgtt  caagaagaa  ggtatttta  agacgtgaa  1800
aagttcttg  atgaaattt  gtctacgga  actaaggag  ccagtggta  gagtgagcc  1860
gtgcacctg  aagaaggtg  gatgtataa  agagctcaa  gaagaaccc  tattggaaa  1920
aagaacttc  agaaacgat  gttctgctt  acaagcaaa  agctcacct  ccacaaaca  1980
caaggcaaa  atgcaattt  cactattcc  gtaaagaac  ttcttgctg  ggaaaaact  2040
gaagaaagc  ctttcaaca  gaaaaatat  ttccaagtg  tccatacgg  gaaaacgct  2100
tacatccaa  cgaataact  tgtggaagc  aatgagtgg  tcgacatgc  gtgcagggt  2160
agcaggtgc  accacaaca  gctcagctc  ttccacccg  cagcatatc  caacggaaa  2220
tggctctgc  gccaggaga  cagtgaagg  acaccaggc  gcaagccat  cactgcagg  2280
atccctgca  acatccaga  agatattga  gaagacaga  aaacagaaa  aatttactc  2340
gtttttacc  tcagtttac  taaactgca  aagatggaa  aggcttgtg  gtctatagc  2400
gtatatcag  ggccacaga  agaacctgg  tattctaag  tcaccatcg  ggattctgt  2460
gcaaccttt  agacaattc  gcaaataaa  agcaccata  agaaactag  tgaacctca  2520
gagaaatac  ggaagaaaa  atcgagtag  gcaaaatac  gaagcaagg  aaatccaat  2580
gtgggaaaa  tatcatagt  tttgatcaa  tgacggaga  ctggaaaat  ctcttatca  2640
caagttttt  aattcaccc  atttgttcc  gtgtgtaag  gcagacatt  gctttgaag  2700
cacctgctc  tgcaatgta  ttaatattt  atgattgaa  ttaactggg  atcctgata  2760
tgatgtgtt  attactaaa  aatttgaaa  ccaagattt  cttcatagc  atgcatcca  2820
atccatgtc  ctgcaactt  ctttcaaca  aaaggatct  tctaaggaa  gttcccaag  2880
agctttgta  taagggagc  cttgctagc  agaagccat  tctacttgg  gcactcctg  2940
gtcactcac  accatcagt  cctgccctg  gctgccaac  ttgagcttc  agagaa  2996



<210> 1946
<211> 847
<212> PRT
<213> Rattus norvegicus
<308> BAA06398
<400> 1946

Met Ala Ala Ala Ala Pro Ala Ala Ala Ala Leu Thr Glu Ala Pro Ala 
  1               5                  10                  15
Val Pro Gly Thr Ala Glu Pro Glu Thr Gly Asp Glu Asp Ser Arg Glu 
             20                  25                  30
Val Arg Val Leu Gln Ser Leu Arg Gly Arg Ile Tyr Glu Ala Lys Asn 
         35                  40                  45
Leu Leu Pro Tyr Leu Gly Pro Asn Lys Met Arg Asp Cys Phe Cys Thr 
     50                  55                  60
Ile Asn Leu Asp Gln Glu Glu Val Tyr Arg Thr Gln Val Val Glu Lys 
 65                  70                  75                  80
Ser Leu Ser Pro Tyr Phe Ser Glu Glu Phe Tyr Phe Glu Ile Pro Arg 
                 85                  90                  95
Thr Phe Gln Tyr Leu Ser Phe Tyr Val Tyr Asp Lys Asn Val Leu Gln 
             100                105                110
Arg Asp Leu Arg Ile Gly Lys Val Ala Ile Lys Lys Glu Asp Leu Cys 
         115                120                125
Ser His Ser Gly Lys Glu Thr Trp Phe Ser Leu Gln Pro Ile Asp Ser 
     130                135                140
Asn Ser Glu Val Gln Gly Lys Val His Leu Glu Leu Lys Leu Asn Glu 
 145                150                155                160
Leu Ile Thr Glu Asn Gly Thr Val Cys Gln Gln Leu Val Val His Ile 
                 165                170                175
Lys Ala Cys His Gly Leu Pro Leu Ile Asn Gly Gln Ser Cys Asp Pro 
             180                185                190
Tyr Ala Thr Val Ser Leu Val Gly Pro Ser Arg Asn Asp Gln Lys Lys 
         195                200                205
Thr Lys Val Lys Lys Lys Thr Ser Asn Pro Gln Phe Asn Glu Val Phe 
     210                215                220
Tyr Phe Glu Val Thr Arg Ser Ser Ser Tyr Thr Arg Lys Ser Gln Phe 
 225                230                235                240
Gln Val Glu Glu Glu Asp Ile Glu Lys Leu Glu Ile Arg Ile Asp Leu 
                 245                250                255
Trp Asn Asn Glu Asn Leu Val Gln Asp Val Phe Leu Gly Glu Ile Lys 
             260                265                270
Val Pro Val Asn Val Leu Arg Asn Asp Ser Ser His Gln Ala Trp Tyr 
         275                280                285
Leu Leu Gln Pro Arg Asp Asn Gly Asn Lys Ser Ser Lys Pro Asp Asp 
     290                295                300
Leu Gly Ser Leu Leu Leu Thr Leu Cys Tyr Thr Glu Asp Tyr Val Leu 
 305                310                315                320
Pro Ser Glu Tyr Tyr Gly Pro Leu Lys Ala Leu Leu Leu Lys Ser Pro 
                 325                330                335
Asp Val Gln Pro Val Ser Ala Ser Ala Ala Tyr Ile Leu Gly Glu Ile 
             340                345                350
Cys Arg Asp Gln Lys Asp Ala Val Leu Pro Leu Val Arg Leu Leu Leu 
         355                360                365
His His Asn Lys Leu Val Pro Phe Ile Thr Ala Val Ala Asp Leu Asp 
     370                375                380
Leu Lys Asp Thr Gln Asp Ala Asn Ala Ile Phe Arg Gly Asn Ser Leu 
 385                390                395                400
Ala Thr Gln Cys Leu Thr Glu Met Met Lys Ile Val Gly Gly His Tyr 
                 405                410                415
Leu Lys Val Thr Leu Lys Pro Val Leu Asp Glu Ile Cys Glu Ser Ser 
             420                425                430
Lys Ser Cys Glu Ile Asp Pro Val Lys Leu Lys Glu Gly Asp Asn Val 
         435                440                445
Glu Ser Asn Lys Glu Asn Leu Tyr Tyr Tyr Val Asp Lys Val Phe Ser 
     450                455                460
Ala Ile Val Gly Ser Ser Val Ser Cys Pro Thr Val Met Cys Asp Ile 
 465                470                475                480
Phe Tyr Ser Leu Arg Gln Met Ala Ala Lys Arg Phe Pro Asn Asn Pro 
                 485                490                495
His Val Gln Tyr Ser Ala Val Ser Ser Phe Val Phe Leu Arg Phe Phe 
             500                505                510
Ala Val Ala Ile Leu Ser Pro His Ala Phe His Leu Arg Pro His Tyr 
         515                520                525
Pro Asp Thr Gln Thr Val Arg Thr Leu Thr Leu Ile Ser Lys Thr Ile 
     530                535                540
Gln Ile Ile Gly Asn Trp Gly Cys Gln Ser Arg Arg Lys Ser Arg Phe 
 545                550                555                560
Lys Lys Ser Val Met Cys Glu Phe Leu Lys Met Phe Gln Glu Glu Arg 
                 565                570                575
Tyr Phe Thr Asp Val Lys Lys Phe Leu Asp Glu Ile Ser Ser Thr Glu 
             580                585                590
Thr Lys Glu Ser Ser Gly Thr Ser Glu Pro Val His Leu Lys Glu Gly 
         595                600                605
Glu Met Tyr Lys Arg Ala Gln Gly Arg Thr Arg Ile Gly Lys Lys Asn 
     610                615                620
Phe Lys Lys Arg Trp Phe Cys Leu Thr Ser Lys Glu Leu Thr Tyr His 
 625                630                635                640
Lys Gln Gln Gly Lys Asp Ala Ile Tyr Thr Ile Pro Val Lys Asn Ile 
                 645                650                655
Leu Ala Val Glu Lys Leu Glu Glu Ser Ser Phe Asn Lys Lys Asn Met 
             660                665                670
Phe Gln Val Ile His Thr Glu Lys Thr Leu Tyr Ile Gln Ala Asn Asn 
         675                680                685
Cys Val Glu Ala Asn Glu Trp Ile Asp Met Leu Cys Arg Val Ser Arg 
     690                695                700
Cys Asn His Asn Arg Leu Ser Ser Phe His Pro Ser Ala Tyr Leu Asn 
 705                710                715                720
Gly Asn Trp Leu Cys Cys Gln Glu Thr Ser Glu Gly Thr Pro Gly Cys 
                 725                730                735
Lys Pro Cys Thr Ala Gly Ile Pro Ala Asp Ile Gln Ile Asp Ile Asp 
             740                745                750
Glu Asp Arg Glu Thr Glu Arg Ile Tyr Ser Val Phe Thr Leu Ser Leu 
         755                760                765
Leu Lys Leu Gln Lys Met Glu Glu Ala Cys Gly Ser Ile Ala Val Tyr 
     770                775                780
Gln Gly Pro Gln Lys Glu Pro Gly Tyr Ser Lys Phe Thr Ile Glu Asp 
 785                790                795                800
Ser Val Ala Thr Phe Lys Thr Ile Gln Gln Ile Lys Ser Thr Ile Glu 
                 805                810                815
Lys Leu Asp Glu Pro His Glu Lys Tyr Arg Lys Lys Arg Ser Ser Ser 
             820                825                830
Ala Lys Tyr Gly Ser Lys Glu Asn Pro Ile Val Gly Lys Ile Ser 
         835                840                845



<210> 1947
<211> 2553
<212> DNA
<213> Homo sapiens
<308> D78155
<400> 1947

atggcggcg  cggcgcctg  tgctgcggc  gcttcttcc  aggcgccag  ggcgagtgc  60
actgcagag  ccgaggccg  ggaccagga  agtcgcgag  ttcgagtgt  gcagagcct  120
cggggcaag  tctgtgaag  aaaaaattt  ttgccatat  ttggacccc  caaaatgag  180
gattgtttc  gtaccataa  tttggacca  gaagaagtt  atcgtaccc  agttgtgga  240
aaatcttta  gcccatttt  cagtgaaga  ttttacttt  agattccaa  aactttcca  300
tatttgtct  tctatgttt  tgataagaa  gttttacaa  gagatctcc  tataggaaa  360
gtagccatc  aaaaagaag  cttgtgtaa  cacagtggc  aagaaactt  gttttcatt  420
cagcctgtt  actccaatt  agaggttca  ggtaaagtt  accttgaat  aaaactgaa  480
gaactgata  cggagaatg  aactgtatg  cagcagctt  ttgtacaca  caaggcatg  540
catgggttg  ctctcataa  tggccaaag  tgtgaccct  atgcaacag  ttctctagt  600
ggcccttct  ggaatgacc  aaagaagac  aaagtaaag  agaaagcaa  caatccgca  660
tttaatgaa  tcttttatt  tgaggtaac  agatccagt  gctacacca  aaagtccca  720
ttccaggta  aagaggagg  cattgaaaa  ctagaaatc  ggatcgact  gtggaacaa  780
ggaaaccta  tccaagatg  tttcctagg  gagattaag  ttcctgtga  cgtattaag  840
actgattcc  ctcatcaag  ctggtactt  ctacagcca  gagacaatg  aaacaagtc  900
tccaaaact  atgacctgg  gtctcttcg  ttaaatata  gttatacag  agactacgt  960
cttccttca  agtactatg  tcctttgaa  actttgctg  taaaatcac  agatgttca  1020
ccaatatct  cctcagctg  ttacatttt  agtgaaata  gtcgagata  aaatgatgc  1080
gttttgccc  ttgtacgac  gctgctgca  catgataaa  ttgttcctt  tgccactgc  1140
gtggctgaa  tagacttga  ggatacaca  gatgcaaac  caattttta  aggaaattc  1200
ctggctacc  gatgtctgg  tgagatgat  aaaatagtg  gagggcact  cctgaaagt  1260
acattaaaa  ctattcttg  tgagatatg  gactcctca  aatcctgtg  aatcgatcc  1320
attaaattg  aagagggag  taatgtaga  aataataag  agaatctgc  ctactatgt  1380
gacaagtta  tcaatacaa  tgtaaaatc  agtatgagc  gccccactg  aatgtgtga  1440
atcttttat  ctctaaggc  gatggctac  cagagattt  ctaatgacc  tcatgttca  1500
tattctgca  tgagcagct  tgtatttct  cgtttcttt  ctgtagcgg  agtatcacc  1560
catactttt  atttgcgac  tcatcatcc  gatgcacag  caattagaa  attaactct  1620
atctcaaaa  ctatacaaa  tttgggaag  tgggggagt  tgtccaaaa  caagtcaag  1680
ttcaaagag  cattcatgt  tgaattttt  aaaatgttt  aagaagaag  atatattat  1740
gcagttaaa  agttcttgg  tgaaatttc  tctactgaa  ctaaagagt  cagtggtac  1800
agtgagcct  tgcacctga  agaaggtga  atgtataaa  gagctcaag  aagaactcg  1860
attggaaaa  agaatttta  gaaacgatg  ttctgctta  caagcagag  gctcaccta  1920
cacaaacag  caggtagca  agatgcaat  tacacaatc  cagtaaaaa  cattcttgc  1980
gtggaaaaa  tggaagaga  ctctttcaa  aagaaaaac  tgttccaag  aatacatac  2040
gagaaacca  tctatgtcc  ggcaaataa  tgtgtagaa  ctaatgaat  gatagacgt  2100
ctctgcagg  tgagccgat  caatcaaaa  aggctcagt  tttatcatc  ctctgtgta  2160
ctaaacgga  attggctct  ctgtcagga  actggtgaa  acactctcg  ctgcaagcc  2220
tgtactgca  gtgtccctg  agacatcca  atagatatt  atgaagaca  agaaacaga  2280
agaatttat  cccttttta  cctcagttt  cttaagctg  agaagatgg  agaggcttg  2340
ggaactatt  cagtctatc  aggaccaca  aaagagcct  atgattatt  taactttgt  2400
atcgaggat  ctgtaacaa  ctttaagac  attcagcaa  taaaaagca  aattgagaa  2460
ctggatgaa  ctcatgaaa  atataggaa  aaaagatcc  gtagtgcaa  atatgggag  2520
aaggaaaat  caattgttg  gaaagcatc  tag  2553



<210> 1948
<211> 849
<212> PRT
<213> Homo sapiens
<308> Q15283
<400> 1948

Met Ala Ala Ala Ala Pro Ala Ala Ala Ala Ala Ser Ser Glu Ala Pro 
  1               5                  10                  15
Ala Ala Ser Ala Thr Ala Glu Pro Glu Ala Gly Asp Gln Asp Ser Arg 
             20                  25                  30
Glu Val Arg Val Leu Gln Ser Leu Arg Gly Lys Ile Cys Glu Ala Lys 
         35                  40                  45
Asn Leu Leu Pro Tyr Leu Gly Pro His Lys Met Arg Asp Cys Phe Cys 
     50                  55                  60
Thr Ile Asn Leu Asp Gln Glu Glu Val Tyr Arg Thr Gln Val Val Glu 
 65                  70                  75                  80
Lys Ser Leu Ser Pro Phe Phe Ser Glu Glu Phe Tyr Phe Glu Ile Pro 
                 85                  90                  95
Arg Thr Phe Gln Tyr Leu Ser Phe Tyr Val Tyr Asp Lys Asn Val Leu 
             100                105                110
Gln Arg Asp Leu Arg Ile Gly Lys Val Ala Ile Lys Lys Glu Asp Leu 
         115                120                125
Cys Asn His Ser Gly Lys Glu Thr Trp Phe Ser Leu Gln Pro Val Asp 
     130                135                140
Ser Asn Ser Glu Val Gln Gly Lys Val His Leu Glu Leu Lys Leu Asn 
 145                150                155                160
Glu Leu Ile Thr Glu Asn Gly Thr Val Cys Gln Gln Leu Val Val His 
                 165                170                175
Ile Lys Ala Cys His Gly Leu Pro Leu Ile Asn Gly Gln Ser Cys Asp 
             180                185                190
Pro Tyr Ala Thr Val Ser Leu Val Gly Pro Ser Arg Asn Asp Gln Lys 
         195                200                205
Lys Thr Lys Val Lys Lys Lys Thr Ser Asn Pro Gln Phe Asn Glu Ile 
     210                215                220
Phe Tyr Phe Glu Val Thr Arg Ser Ser Ser Tyr Thr Arg Lys Ser Gln 
 225                230                235                240
Phe Gln Val Glu Glu Glu Asp Ile Glu Lys Leu Glu Ile Arg Ile Asp 
                 245                250                255
Leu Trp Asn Asn Gly Asn Leu Val Gln Asp Val Phe Leu Gly Glu Ile 
             260                265                270
Lys Val Pro Val Asn Val Leu Arg Thr Asp Ser Ser His Gln Ala Trp 
         275                280                285
Tyr Leu Leu Gln Pro Arg Asp Asn Gly Asn Lys Ser Ser Lys Thr Asp 
     290                295                300
Asp Leu Gly Ser Leu Arg Leu Asn Ile Cys Tyr Thr Glu Asp Tyr Val 
 305                310                315                320
Leu Pro Ser Glu Tyr Tyr Gly Pro Leu Lys Thr Leu Leu Leu Lys Ser 
                 325                330                335
Pro Asp Val Gln Pro Ile Ser Ala Ser Ala Ala Tyr Ile Leu Ser Glu 
             340                345                350
Ile Cys Arg Asp Lys Asn Asp Ala Val Leu Pro Leu Val Arg Leu Leu 
         355                360                365
Leu His His Asp Lys Leu Val Pro Phe Ala Thr Ala Val Ala Glu Leu 
     370                375                380
Asp Leu Lys Asp Thr Gln Asp Ala Asn Thr Ile Phe Arg Gly Asn Ser 
 385                390                395                400
Leu Ala Thr Arg Cys Leu Asp Glu Met Met Lys Ile Val Gly Gly His 
                 405                410                415
Tyr Leu Lys Val Thr Leu Lys Pro Ile Leu Asp Glu Ile Cys Asp Ser 
             420                425                430
Ser Lys Ser Cys Glu Ile Asp Pro Ile Lys Leu Lys Glu Gly Asp Asn 
         435                440                445
Val Glu Asn Asn Lys Glu Asn Leu Arg Tyr Tyr Val Asp Lys Leu Phe 
     450                455                460
Asn Thr Ile Val Lys Ser Ser Met Ser Cys Pro Thr Val Met Cys Asp 
 465                470                475                480
Ile Phe Tyr Ser Leu Arg Gln Met Ala Thr Gln Arg Phe Pro Asn Asp 
                 485                490                495
Pro His Val Gln Tyr Ser Ala Val Ser Ser Phe Val Phe Leu Arg Phe 
             500                505                510
Phe Ala Val Ala Val Val Ser Pro His Thr Phe His Leu Arg Pro His 
         515                520                525
His Pro Asp Ala Gln Thr Ile Arg Thr Leu Thr Leu Ile Ser Lys Thr 
     530                535                540
Ile Gln Thr Leu Gly Ser Trp Gly Ser Leu Ser Lys Ser Lys Ser Ser 
 545                550                555                560
Phe Lys Glu Thr Phe Met Cys Glu Phe Phe Lys Met Phe Gln Glu Glu 
                 565                570                575
Gly Tyr Ile Ile Ala Val Lys Lys Phe Leu Asp Glu Ile Ser Ser Thr 
             580                585                590
Glu Thr Lys Glu Ser Ser Gly Thr Ser Glu Pro Val His Leu Lys Glu 
         595                600                605
Gly Glu Met Tyr Lys Arg Ala Gln Gly Arg Thr Arg Ile Gly Lys Lys 
     610                615                620
Asn Phe Lys Lys Arg Trp Phe Cys Leu Thr Ser Arg Glu Leu Thr Tyr 
 625                630                635                640
His Lys Gln Pro Gly Lys Asp Ala Ile Tyr Thr Ile Pro Val Lys Asn 
                 645                650                655
Ile Leu Ala Val Glu Lys Leu Glu Glu Ser Ser Phe Asn Lys Lys Asn 
             660                665                670
Met Phe Gln Val Ile His Thr Glu Lys Pro Leu Tyr Val Gln Ala Asn 
         675                680                685
Asn Cys Val Glu Ala Asn Glu Trp Ile Asp Val Leu Cys Arg Val Ser 
     690                695                700
Arg Cys Asn Gln Asn Arg Leu Ser Phe Tyr His Pro Ser Val Tyr Leu 
 705                710                715                720
Asn Gly Asn Trp Leu Cys Cys Gln Glu Thr Gly Glu Asn Thr Leu Gly 
                 725                730                735
Cys Lys Pro Cys Thr Ala Gly Val Pro Ala Asp Ile Gln Ile Asp Ile 
             740                745                750
Asp Glu Asp Arg Glu Thr Glu Arg Ile Tyr Ser Leu Phe Thr Leu Ser 
         755                760                765
Leu Leu Lys Leu Gln Lys Met Glu Glu Ala Cys Gly Thr Ile Ala Val 
     770                775                780
Tyr Gln Gly Pro Gln Lys Glu Pro Asp Asp Tyr Ser Asn Phe Val Ile 
 785                790                795                800
Glu Asp Ser Val Thr Thr Phe Lys Thr Ile Gln Gln Ile Lys Ser Ile 
                 805                810                815
Ile Glu Lys Leu Asp Glu Pro His Glu Lys Tyr Arg Lys Lys Arg Ser 
             820                825                830
Ser Ser Ala Lys Tyr Gly Ser Lys Glu Asn Pro Ile Val Gly Lys Ala 
         835                840                845
Ser 
     850



<210> 1949
<211> 1728
<212> DNA
<213> Rattus norvegicus
<308> D30739
<400> 1949

agcgagaag  tgagagagt  gagacgcta  ccgcttcca  ccgtcgtgc  gaccctgcc  60
gagccgctg  cgctatgga  gatcgggag  atctggtgt  ccaggcgaa  ctggcagag  120
aggccgagc  atacgacga  atggtggaa  caatgaaga  agtcgcagg  atggacgtg  180
agctgacag  tgaagaacg  aacctttta  ctgttgcat  taaaaatgt  attggagcc  240
gaagagcat  ctggagaat  atcagcagc  ttgaacaga  ggaagaaaa  aagggagga  300
aggacaaat  aaagatgat  cgggagtac  ggcaaatgg  tgaaactga  ctcaagtta  360
tctgttgtg  cattctgga  gtactggac  agcacctca  tccagcagc  aacactggc  420
agtccaagg  tttctatta  aaaatgaaa  gggactacc  caggtatct  gctgagttt  480
ccacaggaa  cgacaggaa  gaggcagca  agaacagcc  tgtggctta  aaagctgct  540
gtgacattg  gatgacaga  cttcctcca  cgcacccca  tcgtttagg  cttgctctc  600
acttttccg  attctacta  gaaattctt  attcccccg  ccgtgcctg  aggttggca  660
aagcagctt  tgatgacgc  attgcagaa  tggacacgc  gagtgaaga  agctataag  720
actccacac  catcatgca  ctgctacgt  ataacctga  gctgtggac  tcagacatg  780
agggcgatg  tgaagagca  aataaagaa  cgctgcagg  tgtggaaga  gagaatcag  840
gagacgtaa  aaagccaac  aagagaaac  atctctgac  accccaccc  acccctgcc  900
ttggaagtt  cccattgtc  ctgagaacc  ccaaatttg  ctttcacat  tggtctcag  960
atttaggtt  ctgccctgt  gtttttctt  ctttttctt  tttttctcc  ctccccttt  1020
ttaaaacaa  cagttttca  aagttctta  ggaagagtg  atttctgtg  attttactg  1080
tccagcttt  ggttcttta  gacactaac  ggactgcat  gaggctttt  cagcattac  1140
gtattgtct  cggccacat  acgaagatc  tcattagaa  tggaaatga  atttgagag  1200
cattagact  ctaggtgat  catctaaga  agattaatc  cacaataga  gcatatgcg  1260
tgtcatttt  ccttttttt  attgttaaa  tgaatttta  accaatgtt  aaacttaaa  1320
tgggtgtta  cttgaggtg  tttggggga  tttgcggta  tggttttgc  gtaacgtgt  1380
tttggaact  tgctgaagg  ctgctgaaa  gcacggtgc  ggtaacagt  caacagtcg  1440
ggctgctca  tcttgccga  tcctccctc  gacgcaggt  agcattgaa  gtggtatgg  1500
agcctgcat  cgtgttcaa  tcttcctct  ttccctcct  ctcggcctc  ctcatccct  1560
cctccttcg  tcgctcaac  tcttttgtt  agtagtgta  cttgaagct  atttgtact  1620
ctggtatct  actggagcc  cagatacag  tctgtattg  tcttactga  acacagcat  1680
gaattaaca  taaacttaa  taaaacaaa  ctaaattaa  aaatgccg  1728



<210> 1950
<211> 255
<212> PRT
<213> Rattus norvegicus
<308> BAA06401
<400> 1950

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
  1               5                  10                  15
Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
             20                  25                  30
Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
         35                  40                  45
Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
     50                  55                  60
Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
 65                  70                  75                  80
Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                 85                  90                  95
Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
             100                105                110
Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
         115                120                125
His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
     130                135                140
Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
 145                150                155                160
Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                 165                170                175
Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
             180                185                190
Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
         195                200                205
Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
     210                215                220
Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
 225                230                235                240
Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                 245                250                255



<210> 1951
<211> 2834
<212> DNA
<213> Homo sapiens
<308> NM_003406
<400> 1951

gcccactcc  accgccagc  ggaaccctg  ggactacga  gtccctcaa  ccttgcttc  60
aggagataa  aagaacatc  agtcatgga  aaaaatgag  tggttcaga  ggccaaact  120
gccgagcag  ctgagcgat  tgatgacat  gcagcctgc  tgaagtctg  aactgagca  180
ggagctgaa  tatccaatg  ggagaggaa  cttctctca  ttgcttata  aaatgttgt  240
ggagcccgt  ggtcatctt  gagggtcgt  tcaagtatt  aacaaaaga  ggaaggtgc  300
gagaaaaaa  agcagatgg  tcgagaata  agagagaaa  ttgagacgg  gctaagaga  360
atctgcaat  atgtactgt  tcttttgga  aagttcttg  tccccaatg  ttcacaagc  420
gagagcaaa  tcttctatt  gaaaatgaa  ggagattac  accgttact  ggctgaggt  480
gccgctggt  atgacaaga  agggattgt  gatcagtca  aacaagcat  ccaagaagc  540
tttgaaatc  gcaaaaagg  aatgcaacc  acacatcct  tcagactgg  tctggccct  600
aacttctct  tgttctatt  tgagattct  aactcccca  agaaagcct  ctctcttgc  660
aagacagct  ttgatgaag  cattgctga  cttgataca  taagtgaag  gtcatacaa  720
gacagcacg  taataatgc  attactgag  gacaacttg  cattgtgga  atcggatac  780
caaggagac  aagctgaag  aggagaagg  ggggaaaat  aaccggcct  ccaactttt  840
tctgcctca  tctaaaatt  acacagtag  ccatttgtc  tccatgctg  cccacaaat  900
gttttttgt  tacgattta  gacaggttt  tgttacttc  atttgaatt  ctatatttc  960
catgtggtt  ttatgttta  tattagggg  gtagagcca  ttaacattt  gggagttat  1020
tgttttcat  ttgaggtgg  caatatggg  atgtggaat  tttatacaa  ttataagtg  1080
ttggcatag  acttttggt  cattgtggc  tcaaaaggg  cagtgtaaa  ctgcttcca  1140
gtctaagca  agaaaactg  ctacatact  gtttgtcct  gcggggaat  aaagggatc  1200
ttggttcca  tcacaggtg  agtaattgt  ggtacttta  ggtttggag  acttacaag  1260
ctgtggtag  atcataccc  atggatacc  catattaaa  catgtatat  tgtggaata  1320
tcaatgtgt  cacctttga  tacagctgc  gaagtgttc  tttagacaa  gttgtgacc  1380
attttactc  ggataaggg  agaaacggt  cacattcca  tatttgtaa  gttacctgc  1440
gttagcttt  attattttt  ctacactca  tttatttgt  tttaaatgt  ttaggcaac  1500
taagaacaa  tgtaaaagt  aagatgcag  aaaaatgaa  tgcttggta  tcattactt  1560
atgtatatc  agcacagca  taaaacaaa  acccatgta  ttaactttt  tttaggatt  1620
ttgcttttg  gattttttt  ttttttttt  gatacttgc  taacatgca  gtgctgtaa  1680
aatagttaa  agggaaata  cttgagatg  tggctagct  tgtttaatg  cttatgaaa  1740
tttcatgaa  aatccaagc  taattgtta  gaacacgtg  attaaattc  tgtaagtgg  1800
ataaaagtt  tatgaatgg  cttttcaac  actttctct  cagcttttc  tgtaaatta  1860
tcttggttc  gaaacttct  taaaggaaa  tgtacattt  ttgaaattt  ttccttatt  1920
cctcttggc  gctaatggg  tcttaccaa  tttaaacac  aaatttatc  taacaaaaa  1980
actactaat  taactactg  ttccatgtc  catgatccc  tctcttcct  cccaccctg  2040
aaaaaatga  ttcctattt  ttctgggag  gggggggat  gattagaaa  aaatgtagt  2100
tgttccatt  aaaattttg  catatggca  tttctaact  aggaagcca  aatgttctt  2160
gcccatcat  acattgggt  gcattaact  taagttttg  gcttccaaa  cactttttg  2220
tttttaaga  tttcttgat  ctcttatag  ctgccttca  ttttgatcc  ttattcttt  2280
tatttgtca  gtgcacaag  ttaccttcc  gttttagcc  tctgtcttg  caccaacca  2340
tcttacttg  tggccatgt  cttggaaaa  ggccgcatg  tctttctgg  tccactcag  2400
gtctaaggc  ccctgcttc  tttgcttgc  tcccacaga  tatttccct  atcctattt  2460
ctgcagcaa  tctctcctt  gttgatgag  ctgtgttta  ctcccttta  aaccctacc  2520
atcctgaat  gtctgtcat  gtctgcctt  aaaatcctt  ctctttctt  ctcctctat  2580
ctctaaata  tgatggggc  aagttatac  caaagctca  tttacaaaa  atttcctca  2640
tactttgca  aaaacacca  acaaaaatg  cattttaaa  aaggtgtat  ttttctttt  2700
gaatgtaag  tcctcaaga  cagggacaa  gttttctgt  tgttctatt  tgcctagta  2760
actgtaaat  ctcaataaa  attgatgat  ggaggcagt  agtcttgat  ataagggtg  2820
gaaactgaa  tccc  2834



<210> 1952
<211> 245
<212> PRT
<213> Homo sapiens
<308> P29312
<400> 1952

Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala 
  1               5                  10                  15
Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln 
             20                  25                  30
Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
         35                  40                  45
Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser 
     50                  55                  60
Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg 
 65                  70                  75                  80
Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp 
                 85                  90                  95
Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Ala 
             100                105                110
Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr 
         115                120                125
Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln 
     130                135                140
Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met 
 145                150                155                160
Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                 165                170                175
Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala 
             180                185                190
Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu 
         195                200                205
Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
     210                215                220
Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly 
 225                230                235                240
Glu Gly Gly Glu Asn 
                 245



<210> 1954
<211> 254
<212> PRT
<213> Rattus norvegicus
<308> BAA06463
<400> 1954

Met Ser Tyr Asp Arg Ala Ile Thr Val Phe Ser Pro Asp Gly His Leu 
  1               5                  10                  15
Phe Gln Val Glu Tyr Ala Gln Glu Ala Val Lys Lys Gly Ser Thr Ala 
             20                  25                  30
Val Gly Val Arg Gly Arg Asp Ile Val Val Leu Gly Val Glu Lys Lys 
         35                  40                  45
Ser Val Ala Lys Leu Gln Asp Glu Arg Thr Val Arg Lys Ile Cys Ala 
     50                  55                  60
Leu Asp Asp Asn Val Cys Met Ala Phe Ala Val Val Ala Ser Val Ser 
 65                  70                  75                  80
Gly Leu Thr Ala Asp Ala Arg Ile Val Ile Asn Arg Ala Arg Val Glu 
                 85                  90                  95
Cys Gln Ser His Arg Leu Thr Val Gly Asp Pro Val Thr Val Glu Tyr 
             100                105                110
Ile Thr Arg Tyr Ile Ala Ser Leu Lys Gln Arg Tyr Thr Gln Ser Asn 
         115                120                125
Gly Arg Arg Pro Phe Gly Ile Ser Ala Leu Ile Val Gly Phe Asp Phe 
     130                135                140
Asp Gly Thr Pro Arg Leu Tyr Gln Thr Asp Pro Ser Gly Thr Tyr His 
 145                150                155                160
Ala Trp Lys Ala Asn Ala Ile Gly Arg Gly Ala Lys Ser Val Arg Glu 
                 165                170                175
Phe Leu Glu Lys Asn Tyr Thr Asp Asp Ala Ile Glu Thr Asp Asp Leu 
             180                185                190
Thr Ile Lys Leu Val Ile Lys Ala Leu Leu Glu Val Val Gln Ser Gly 
         195                200                205
Gly Lys Asn Ile Glu Leu Ala Val Met Arg Arg Asp Gln Pro Leu Lys 
     210                215                220
Ile Leu Ser Pro Glu Glu Ile Glu Lys Tyr Val Ala Glu Ile Glu Lys 
 225                230                235                240
Glu Lys Glu Glu Asn Glu Lys Lys Lys Gln Lys Lys Ala Ser 
                 245                250



<210> 1956
<211> 248
<212> PRT
<213> Homo sapiens
<308> O14818
<400> 1956

Met Ser Tyr Asp Arg Ala Ile Thr Val Phe Ser Pro Asp Gly His Leu 
  1               5                  10                  15
Phe Gln Val Glu Tyr Ala Gln Glu Ala Val Lys Lys Gly Ser Thr Ala 
             20                  25                  30
Val Gly Val Arg Gly Arg Asp Ile Val Val Leu Gly Val Glu Lys Lys 
         35                  40                  45
Ser Val Ala Lys Leu Gln Asp Glu Arg Thr Val Arg Lys Ile Cys Ala 
     50                  55                  60
Leu Asp Asp Asn Val Cys Met Ala Phe Ala Gly Leu Thr Ala Asp Ala 
 65                  70                  75                  80
Arg Ile Val Ile Asn Arg Ala Arg Val Glu Cys Gln Ser His Arg Leu 
                 85                  90                  95
Thr Val Glu Asp Pro Val Thr Val Glu Tyr Ile Thr Arg Tyr Ile Ala 
             100                105                110
Ser Leu Lys Gln Arg Tyr Thr Gln Ser Asn Gly Arg Arg Pro Phe Gly 
         115                120                125
Ile Ser Ala Leu Ile Val Gly Phe Asp Phe Asp Gly Thr Pro Arg Leu 
     130                135                140
Tyr Gln Thr Asp Pro Ser Gly Thr Tyr His Ala Trp Lys Ala Asn Ala 
 145                150                155                160
Ile Gly Arg Gly Ala Lys Ser Val Arg Glu Phe Leu Glu Lys Asn Tyr 
                 165                170                175
Thr Asp Glu Ala Ile Glu Thr Asp Asp Leu Thr Ile Lys Leu Val Ile 
             180                185                190
Lys Ala Leu Leu Glu Val Val Gln Ser Gly Gly Lys Asn Ile Glu Leu 
         195                200                205
Ala Val Met Arg Arg Asp Gln Ser Leu Lys Ile Leu Asn Pro Glu Glu 
     210                215                220
Ile Glu Lys Tyr Val Ala Glu Ile Glu Lys Glu Lys Glu Glu Asn Glu 
 225                230                235                240
Lys Lys Lys Gln Lys Lys Ala Ser 
                 245



<210> 1958
<211> 254
<212> PRT
<213> Rattus norvegicus
<308> BAA06463
<400> 1958

Met Ser Tyr Asp Arg Ala Ile Thr Val Phe Ser Pro Asp Gly His Leu 
  1               5                  10                  15
Phe Gln Val Glu Tyr Ala Gln Glu Ala Val Lys Lys Gly Ser Thr Ala 
             20                  25                  30
Val Gly Val Arg Gly Arg Asp Ile Val Val Leu Gly Val Glu Lys Lys 
         35                  40                  45
Ser Val Ala Lys Leu Gln Asp Glu Arg Thr Val Arg Lys Ile Cys Ala 
     50                  55                  60
Leu Asp Asp Asn Val Cys Met Ala Phe Ala Val Val Ala Ser Val Ser 
 65                  70                  75                  80
Gly Leu Thr Ala Asp Ala Arg Ile Val Ile Asn Arg Ala Arg Val Glu 
                 85                  90                  95
Cys Gln Ser His Arg Leu Thr Val Gly Asp Pro Val Thr Val Glu Tyr 
             100                105                110
Ile Thr Arg Tyr Ile Ala Ser Leu Lys Gln Arg Tyr Thr Gln Ser Asn 
         115                120                125
Gly Arg Arg Pro Phe Gly Ile Ser Ala Leu Ile Val Gly Phe Asp Phe 
     130                135                140
Asp Gly Thr Pro Arg Leu Tyr Gln Thr Asp Pro Ser Gly Thr Tyr His 
 145                150                155                160
Ala Trp Lys Ala Asn Ala Ile Gly Arg Gly Ala Lys Ser Val Arg Glu 
                 165                170                175
Phe Leu Glu Lys Asn Tyr Thr Asp Asp Ala Ile Glu Thr Asp Asp Leu 
             180                185                190
Thr Ile Lys Leu Val Ile Lys Ala Leu Leu Glu Val Val Gln Ser Gly 
         195                200                205
Gly Lys Asn Ile Glu Leu Ala Val Met Arg Arg Asp Gln Pro Leu Lys 
     210                215                220
Ile Leu Ser Pro Glu Glu Ile Glu Lys Tyr Val Ala Glu Ile Glu Lys 
 225                230                235                240
Glu Lys Glu Glu Asn Glu Lys Lys Lys Gln Lys Lys Ala Ser 
                 245                250



<210> 1960
<211> 248
<212> PRT
<213> Homo sapiens
<308> O14818
<400> 1960

Met Ser Tyr Asp Arg Ala Ile Thr Val Phe Ser Pro Asp Gly His Leu 
  1               5                  10                  15
Phe Gln Val Glu Tyr Ala Gln Glu Ala Val Lys Lys Gly Ser Thr Ala 
             20                  25                  30
Val Gly Val Arg Gly Arg Asp Ile Val Val Leu Gly Val Glu Lys Lys 
         35                  40                  45
Ser Val Ala Lys Leu Gln Asp Glu Arg Thr Val Arg Lys Ile Cys Ala 
     50                  55                  60
Leu Asp Asp Asn Val Cys Met Ala Phe Ala Gly Leu Thr Ala Asp Ala 
 65                  70                  75                  80
Arg Ile Val Ile Asn Arg Ala Arg Val Glu Cys Gln Ser His Arg Leu 
                 85                  90                  95
Thr Val Glu Asp Pro Val Thr Val Glu Tyr Ile Thr Arg Tyr Ile Ala 
             100                105                110
Ser Leu Lys Gln Arg Tyr Thr Gln Ser Asn Gly Arg Arg Pro Phe Gly 
         115                120                125
Ile Ser Ala Leu Ile Val Gly Phe Asp Phe Asp Gly Thr Pro Arg Leu 
     130                135                140
Tyr Gln Thr Asp Pro Ser Gly Thr Tyr His Ala Trp Lys Ala Asn Ala 
 145                150                155                160
Ile Gly Arg Gly Ala Lys Ser Val Arg Glu Phe Leu Glu Lys Asn Tyr 
                 165                170                175
Thr Asp Glu Ala Ile Glu Thr Asp Asp Leu Thr Ile Lys Leu Val Ile 
             180                185                190
Lys Ala Leu Leu Glu Val Val Gln Ser Gly Gly Lys Asn Ile Glu Leu 
         195                200                205
Ala Val Met Arg Arg Asp Gln Ser Leu Lys Ile Leu Asn Pro Glu Glu 
     210                215                220
Ile Glu Lys Tyr Val Ala Glu Ile Glu Lys Glu Lys Glu Glu Asn Glu 
 225                230                235                240
Lys Lys Lys Gln Lys Lys Ala Ser 
                 245



<210> 1962
<211> 254
<212> PRT
<213> Rattus norvegicus
<308> BAA06463
<400> 1962

Met Ser Tyr Asp Arg Ala Ile Thr Val Phe Ser Pro Asp Gly His Leu 
  1               5                  10                  15
Phe Gln Val Glu Tyr Ala Gln Glu Ala Val Lys Lys Gly Ser Thr Ala 
             20                  25                  30
Val Gly Val Arg Gly Arg Asp Ile Val Val Leu Gly Val Glu Lys Lys 
         35                  40                  45
Ser Val Ala Lys Leu Gln Asp Glu Arg Thr Val Arg Lys Ile Cys Ala 
     50                  55                  60
Leu Asp Asp Asn Val Cys Met Ala Phe Ala Val Val Ala Ser Val Ser 
 65                  70                  75                  80
Gly Leu Thr Ala Asp Ala Arg Ile Val Ile Asn Arg Ala Arg Val Glu 
                 85                  90                  95
Cys Gln Ser His Arg Leu Thr Val Gly Asp Pro Val Thr Val Glu Tyr 
             100                105                110
Ile Thr Arg Tyr Ile Ala Ser Leu Lys Gln Arg Tyr Thr Gln Ser Asn 
         115                120                125
Gly Arg Arg Pro Phe Gly Ile Ser Ala Leu Ile Val Gly Phe Asp Phe 
     130                135                140
Asp Gly Thr Pro Arg Leu Tyr Gln Thr Asp Pro Ser Gly Thr Tyr His 
 145                150                155                160
Ala Trp Lys Ala Asn Ala Ile Gly Arg Gly Ala Lys Ser Val Arg Glu 
                 165                170                175
Phe Leu Glu Lys Asn Tyr Thr Asp Asp Ala Ile Glu Thr Asp Asp Leu 
             180                185                190
Thr Ile Lys Leu Val Ile Lys Ala Leu Leu Glu Val Val Gln Ser Gly 
         195                200                205
Gly Lys Asn Ile Glu Leu Ala Val Met Arg Arg Asp Gln Pro Leu Lys 
     210                215                220
Ile Leu Ser Pro Glu Glu Ile Glu Lys Tyr Val Ala Glu Ile Glu Lys 
 225                230                235                240
Glu Lys Glu Glu Asn Glu Lys Lys Lys Gln Lys Lys Ala Ser 
                 245                250



<210> 1964
<211> 248
<212> PRT
<213> Homo sapiens
<308> O14818
<400> 1964

Met Ser Tyr Asp Arg Ala Ile Thr Val Phe Ser Pro Asp Gly His Leu 
  1               5                  10                  15
Phe Gln Val Glu Tyr Ala Gln Glu Ala Val Lys Lys Gly Ser Thr Ala 
             20                  25                  30
Val Gly Val Arg Gly Arg Asp Ile Val Val Leu Gly Val Glu Lys Lys 
         35                  40                  45
Ser Val Ala Lys Leu Gln Asp Glu Arg Thr Val Arg Lys Ile Cys Ala 
     50                  55                  60
Leu Asp Asp Asn Val Cys Met Ala Phe Ala Gly Leu Thr Ala Asp Ala 
 65                  70                  75                  80
Arg Ile Val Ile Asn Arg Ala Arg Val Glu Cys Gln Ser His Arg Leu 
                 85                  90                  95
Thr Val Glu Asp Pro Val Thr Val Glu Tyr Ile Thr Arg Tyr Ile Ala 
             100                105                110
Ser Leu Lys Gln Arg Tyr Thr Gln Ser Asn Gly Arg Arg Pro Phe Gly 
         115                120                125
Ile Ser Ala Leu Ile Val Gly Phe Asp Phe Asp Gly Thr Pro Arg Leu 
     130                135                140
Tyr Gln Thr Asp Pro Ser Gly Thr Tyr His Ala Trp Lys Ala Asn Ala 
 145                150                155                160
Ile Gly Arg Gly Ala Lys Ser Val Arg Glu Phe Leu Glu Lys Asn Tyr 
                 165                170                175
Thr Asp Glu Ala Ile Glu Thr Asp Asp Leu Thr Ile Lys Leu Val Ile 
             180                185                190
Lys Ala Leu Leu Glu Val Val Gln Ser Gly Gly Lys Asn Ile Glu Leu 
         195                200                205
Ala Val Met Arg Arg Asp Gln Ser Leu Lys Ile Leu Asn Pro Glu Glu 
     210                215                220
Ile Glu Lys Tyr Val Ala Glu Ile Glu Lys Glu Lys Glu Glu Asn Glu 
 225                230                235                240
Lys Lys Lys Gln Lys Lys Ala Ser 
                 245



<210> 1966
<211> 254
<212> PRT
<213> Rattus norvegicus
<308> BAA06463
<400> 1966

Met Ser Tyr Asp Arg Ala Ile Thr Val Phe Ser Pro Asp Gly His Leu 
  1               5                  10                  15
Phe Gln Val Glu Tyr Ala Gln Glu Ala Val Lys Lys Gly Ser Thr Ala 
             20                  25                  30
Val Gly Val Arg Gly Arg Asp Ile Val Val Leu Gly Val Glu Lys Lys 
         35                  40                  45
Ser Val Ala Lys Leu Gln Asp Glu Arg Thr Val Arg Lys Ile Cys Ala 
     50                  55                  60
Leu Asp Asp Asn Val Cys Met Ala Phe Ala Val Val Ala Ser Val Ser 
 65                  70                  75                  80
Gly Leu Thr Ala Asp Ala Arg Ile Val Ile Asn Arg Ala Arg Val Glu 
                 85                  90                  95
Cys Gln Ser His Arg Leu Thr Val Gly Asp Pro Val Thr Val Glu Tyr 
             100                105                110
Ile Thr Arg Tyr Ile Ala Ser Leu Lys Gln Arg Tyr Thr Gln Ser Asn 
         115                120                125
Gly Arg Arg Pro Phe Gly Ile Ser Ala Leu Ile Val Gly Phe Asp Phe 
     130                135                140
Asp Gly Thr Pro Arg Leu Tyr Gln Thr Asp Pro Ser Gly Thr Tyr His 
 145                150                155                160
Ala Trp Lys Ala Asn Ala Ile Gly Arg Gly Ala Lys Ser Val Arg Glu 
                 165                170                175
Phe Leu Glu Lys Asn Tyr Thr Asp Asp Ala Ile Glu Thr Asp Asp Leu 
             180                185                190
Thr Ile Lys Leu Val Ile Lys Ala Leu Leu Glu Val Val Gln Ser Gly 
         195                200                205
Gly Lys Asn Ile Glu Leu Ala Val Met Arg Arg Asp Gln Pro Leu Lys 
     210                215                220
Ile Leu Ser Pro Glu Glu Ile Glu Lys Tyr Val Ala Glu Ile Glu Lys 
 225                230                235                240
Glu Lys Glu Glu Asn Glu Lys Lys Lys Gln Lys Lys Ala Ser 
                 245                250



<210> 1968
<211> 248
<212> PRT
<213> Homo sapiens
<308> O14818
<400> 1968

Met Ser Tyr Asp Arg Ala Ile Thr Val Phe Ser Pro Asp Gly His Leu 
  1               5                  10                  15
Phe Gln Val Glu Tyr Ala Gln Glu Ala Val Lys Lys Gly Ser Thr Ala 
             20                  25                  30
Val Gly Val Arg Gly Arg Asp Ile Val Val Leu Gly Val Glu Lys Lys 
         35                  40                  45
Ser Val Ala Lys Leu Gln Asp Glu Arg Thr Val Arg Lys Ile Cys Ala 
     50                  55                  60
Leu Asp Asp Asn Val Cys Met Ala Phe Ala Gly Leu Thr Ala Asp Ala 
 65                  70                  75                  80
Arg Ile Val Ile Asn Arg Ala Arg Val Glu Cys Gln Ser His Arg Leu 
                 85                  90                  95
Thr Val Glu Asp Pro Val Thr Val Glu Tyr Ile Thr Arg Tyr Ile Ala 
             100                105                110
Ser Leu Lys Gln Arg Tyr Thr Gln Ser Asn Gly Arg Arg Pro Phe Gly 
         115                120                125
Ile Ser Ala Leu Ile Val Gly Phe Asp Phe Asp Gly Thr Pro Arg Leu 
     130                135                140
Tyr Gln Thr Asp Pro Ser Gly Thr Tyr His Ala Trp Lys Ala Asn Ala 
 145                150                155                160
Ile Gly Arg Gly Ala Lys Ser Val Arg Glu Phe Leu Glu Lys Asn Tyr 
                 165                170                175
Thr Asp Glu Ala Ile Glu Thr Asp Asp Leu Thr Ile Lys Leu Val Ile 
             180                185                190
Lys Ala Leu Leu Glu Val Val Gln Ser Gly Gly Lys Asn Ile Glu Leu 
         195                200                205
Ala Val Met Arg Arg Asp Gln Ser Leu Lys Ile Leu Asn Pro Glu Glu 
     210                215                220
Ile Glu Lys Tyr Val Ala Glu Ile Glu Lys Glu Lys Glu Glu Asn Glu 
 225                230                235                240
Lys Lys Lys Gln Lys Lys Ala Ser 
                 245



<210> 1969
<211> 3258
<212> DNA
<213> Rattus norvegicus
<308> D31873
<400> 1969

tttccattc  atttattca  actgagtgt  ctacaataa  cttccgtat  tttgcagcggca  cgcggagcc  gtgttcttc  agcctggtg  gggagtgca  cggagcatc  60
tcgccgaag  cggagcgga  cgctcggct  cggccccgc  ctccccgcc  cccgccttc  120
cgggccggc  gcgggcgag  tcgcgggcc  ggccccagc  ctccagtgc  ccgccggtt  180
ccggcggtc  ccgcccccc  ccgagtgca  gaggttgac  ctactttgt  gcacctgga  240
ggaagaacg  atgggagag  aaggaagcg  gttgcctgt  tgtgcgagc  gtagccaga  300
tatctatga  ggccagtac  tccaggccc  gaatgctga  tggcatgcg  attgcttca  360
gtgctgcga  tgtagcacc  ccctttcac  ccagtacta  gagaaggat  gacagctct  420
ctgcaagaa  gactactgg  cccgctatg  cgagtcttg  cacgggtgc  ccgaacaca  480
caccaaagg  ctggtcatg  tgggcgggg  gctgaagta  caccccgag  gcttcatct  540
ccttgcctg  ggaaacttc  tcggtgatg  ggacaccta  acactggtg  agcactcca  600
gctgtactg  gggcagtgc  actaccaga  tgtggtaac  ccagtcatc  aacagatcc  660
ccctgactc  cccggctcc  acctgcccc  cacagtcac  ctcgtgtct  tcccagcct  720
tgctcatgg  aaacgaggc  tgtctgtct  catcgaccc  cctcacggc  caccaggat  780
tggcacgga  cattcgcac  cggtccgag  ccaaggagt  gacccgggc  gcatgagcc  840
ggatgtgaa  aattccatc  acatcggag  caggatctt  gaaatcaac  gcacgccca  900
ccggaatgt  ccgctggac  agatcgact  gctgatcca  gagaccagc  gcctgctcc  960
gctgaccct  gagcacgac  cccatgact  actgggcca  gggccagtg  cggatccca  1020
ccccctggc  tccccggta  acactccca  cggacaggc  ggcagctct  cccggcaga  1080
acctgtctt  aggagctgc  gtattgaca  gtccccggg  gccggctca  tagtctcac  1140
agcctccca  cgcaaggac  tgggtcgct  cgaatccct  cgagtggtt  gtcgaccac  1200
ccgcatctt  cggccgtct  acctcatcc  tggggaggt  ttgggcaag  gctgtttcg  1260
ccaggccat  aaggtgaca  atcgagaaa  gggcgaggt  atggtgatg  aggaactca  1320
ccggtttga  gaggagacc  agaggacat  cctcaagga  gtgaaggtc  tgcgatgcc  1380
ggagcaccc  aacgtgctc  agttcatcg  cgtgctgta  aaggacaag  ggctgaact  1440
catcaccga  tacatcaag  gcggcaccc  gcggggcat  atcaagagc  tggacagcc  1500
gtacccgtg  agtcagagg  tcagctttg  caaggacat  gcatcaggg  tggcctacc  1560
ccattcgat  aacatcatc  accgagacc  caactccca  aactgtctg  tccgtgaga  1620
caggaacgt  gtggtggct  actttgggc  ggctcgact  atgatcgat  agaagggtc  1680
gtctgaaga  ttgcgtagc  ttaagaagc  ggaccgcaa  aaacggtac  cagtggtgg  1740
taaccccta  tggatggcg  cagagatga  caatggtcg  agttacgat  aaaaggtgg  1800
cgtgttttc  tttggaatt  tcctttgtg  gattatcgg  cgtgtgaat  cagaccctg  1860
ctatctgcc  cgcactatg  actttggcc  caatgtaag  ggtttcctg  accgctact  1920
tccaccaaa  tgtccccca  gtttcttcc  catcactgt  cgctgctgt  acctggatc  1980
tgagaagag  ccctctttt  taaagctgg  acaatggct  gaaacactt  gcatgcact  2040
ggctggtca  ctgccactg  gcccacaac  ggaacaact  gagcggggc  tctgggaga  2100
ctaccggcg  ggcgagagc  cgctacccg  ccaccccga  gtccctgac  gagcccagt  2160
ggcccacca  cttcatccc  gcctctgga  aatagaccc  caccagatt  ctcagcagg  2220
ggtggccta  gcatggagc  ctcagctgg  gcagtggtg  ccatatccg  acccccaga  2280
ctgcctttt  ccctcatgc  gggtgcccc  cagcctctc  ctgcctctg  cccccaagt  2340
acaaggctg  acacacacg  ggttggtca  atcgccctg  cttacctcc  attgtgtgg  2400
gccaccccc  cacttgtct  tgcatgagc  ggagggttg  ggaagctga  cccattcca  2460
gcaatgcct  cagctgtct  cacagcgca  ctgctggca  ctcttccca  caaggctgg  2520
ccagaaggc  gctttagaa  tgagccctg  aaggccaag  gagaggcta  gtgcccggg  2580
acccaaggg  agtccagga  cccttgggg  aaatctagg  agcatcagg  attgacagg  2640
atctaaatc  caaagcaga  agagagaga  gtccagtcc  atgtggcca  gcagtggcc  2700
tcgctcttg  ttcgtgtcc  tctcatttc  tgatcaaag  cactttagt  agaagtagg  2760
accagtcct  aggatgagc  aggagccct  aggggagag  gcggatgat  cctgggaac  2820
cagctgaca  ggagggtcc  gcccacacc  cagaggcta  gcagaggga  tgaggtagc  2880
atccaccag  accccagcc  tcccggttc  tctcagcac  cttcctggg  ctctccccg  2940
ggctggagc  gccccaccc  ctccctggg  gcatctgcc  tctgagttc  ttctgtgtg  3000
tctattttt  aagaagagt  tgttttgtt  ttttgtttt  ggtgggtgg  ggtgggagg  3060
ccatctctt  actctgctt  agttgaaca  ctagggacg  attaaaact  tgaagcttt  3120
tcagtgcac  ttgaacatg  aagagaatc  gaacccccg  gggaccagg  ctgaaagag  3180
caaggcctg  ttgcctcgg  ccagtgacc  tgataggaa  gaacccaaa  tcaataaaa  3240
caattctgt  ctcccccc  3258



<210> 1970
<211> 647
<212> PRT
<213> Rattus norvegicus
<308> P53669
<400> 1970

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Ser Gln Ser Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Glu Cys Ser Thr Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu His Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Gly Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Ala Cys Gly Asn Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly Gln Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ala His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Ile Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Ser Leu Gly His Gly Pro Val Ser Asp Pro Ser Pro 
             260                265                270
Leu Ala Ser Pro Val His Thr Pro Ser Gly Gln Ala Gly Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Thr Ser Pro Gly 
     290                295                300
Ala Gly Ser Leu Val Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Arg Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Ile Asp Glu Lys Gly Gln Ser Glu Asp Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu Gln Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Glu Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Ser Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 1971
<211> 3271
<212> DNA
<213> Homo sapiens
<308> NM_016735
<400> 1971

gcgccgagc  ggtttcccc  ccggtgtcc  agaggcgcc  ccggcccgg  ccggcccgg  60
ccgcgccct  cgcccccgc  tccccgggc  ggcggcggt  ggcgagctc  cgggcccgg  120
cgcccccag  cccagcccc  ccgggcccc  ccccccgtc  agtgcatga  gttgacgct  180
ctttgttgc  cctggaggg  agaacgtat  ggagaggaa  gaagcgagt  gcccgtgtg  240
gcaagctgc  gccagagga  ctatgatgg  cagtacctc  aggccctga  cgcggactg  300
cacgcagac  gcttcaggt  ttgtgactg  agtgcctcc  tgtcgcacc  gtactatga  360
aaggatggg  agctcttct  caagaagga  tactgggcc  gctatggcg  gtcctgcca  420
gggtgctct  agcaaatca  caagggact  gttatggtg  ctggggagc  gaagtacca  480
cccgagtgt  tcatctgcc  cacgtgtgg  acctttatc  gtgacgggg  cacctacac  540
ctggtggag  actccaagc  gtactgcgg  cactgctac  accagactg  ggtgacccc  600
gtcatcgag  agatcctgc  tgactcccc  ggctcccac  tgccccaca  cgtcaccct  660
gtgtccatc  cagcctcat  tcatggcaa  cgtggactt  cagtctcca  tgacccccc  720
cacggccca  cgggctgtg  caccgagca  tcacacacc  tccgcgtcc  gggagtgga  780
ccgggctgc  tgagcccag  tgtgaagaa  tccatccac  tcggagacc  gatcttgga  840
atcaatggc  cgcccatcc  aaatgtgcc  ctggacgag  ttgacctgc  gattcagga  900
accagccgc  tgctccagc  gaccctcga  catgaccct  acgatacac  gggccacgg  960
ctggggcct  agaccagcc  cctgagctc  ccggcttat  ctcccagcg  ggaggcggg  1020
agctctgcc  ggcagaaac  tgtcttcgc  aggacctgg  tcgctctga  tccctccgc  1080
tagtctgcc  gccacaccg  atcttccgg  cgtcggacc  catccacgg  gaggtgctg  1140
gcaagggct  cttcggcca  gctatcaag  tgacacacc  tgagacagg  gaggtgatg  1200
tgatgaagg  gctgatccg  ttcgacgag  agacccaga  gacgttcct  aaggaggtg  1260
aggtcatgc  atgcctgga  caccccaac  tgctcaagt  catcggggt  ctctacaag  1320
acaagaggc  caacttcat  actgagtac  tcaagggcg  cacgctccg  ggcatcatc  1380
agagcatgg  cagccagta  ccatggagc  agagagtga  ctttgccaa  gacatcgca  1440
cagggatgg  ctacctcca  tccatgaac  tcatccacc  agacctcaa  tcccacaac  1500
gcctggtcc  cgagaacaa  aatgtggtg  tggctgact  cgggctggc  cgtctcatg  1560
tggacgaga  gactcagcc  gagggcctg  ggagcctca  gaagccaga  cgcaagaag  1620
gctacaccg  ggtgggcaa  ccctactgg  tggcacctg  gatgatcaa  ggccgcagc  1680
atgatgaga  ggtggatgt  ttctccttt  ggatcgtcc  gtgcgagat  atcgggcgg  1740
tgaacgcag  ccctgacta  ctgccccgc  ccatggact  tggcctcaa  gtgcgagga  1800
tcctggacc  ctactgccc  ccaaactgc  ccccgagct  cttccccat  accgtgcgc  1860
gttgcgatc  ggaccccga  aagaggcca  cctttgtga  gctggaaca  tggctggag  1920
ccctccgca  gcacctggc  ggccacctg  cactgggcc  acagctgga  cagctggac  1980
gaggtttct  ggagaccta  cggcgcggc  agagcggac  gcctgccca  cctgaggtc  2040
ccgactgag  cagggccac  cagctgccc  tgtccccac  tctggagaa  ccaccccca  2100
cagattcct  cgcgggagg  ggccctcag  tgggacagt  gggacccag  cttctcctc  2160
gagccaggc  ctgacttgc  ttctcccac  ccgtggacc  cttcccctg  cttctctct  2220
ccgtggccc  gagccggcc  agctgcaca  acacaccat  ctctcgccc  gctgtaacc  2280
ctgtcttgg  agggctgtc  cctcttgct  ctccttgca  gagctggag  gcctgtgtg  2340
gttacgccc  tttccacac  ccgctgccc  agcaaccct  ttcacgctc  acctgtctg  2400
tccatagct  cctggaggc  gggccagga  gcagcctcc  aaccatgcc  catataacg  2460
ttgggtgcg  gggagggcg  acatcaggg  agaggccaa  ttccaggtg  ctgtgttcc  2520
aggaaccaa  tggggagtc  ggggcccgt  ttcccccca  ggggtgtct  ggtagcaac  2580
ggtatcgag  actctccaa  cccccaaag  agagagagg  ctgatccca  ggggcggag  2640
tccccagtg  ctgagcaaa  agccccttc  ctcgctttg  gtctttttt  tgtttcttt  2700
ttaaagcca  tttagtgag  agcaggtac  aagcctcag  gtgaagggg  tcccttgag  2760
gagcgtgga  ctgcggtgc  ctggccggc  atggggagg  gccggctcc  gcagtgaga  2820
gataggcac  gtggaccgg  caggtgtcc  ccagcagct  agcccctgc  gtcatctca  2880
agccccttc  cgggcctct  ccccaaggc  ccctgcccc  cctcatgcc  ctctgtcct  2940
tgcgttttt  ctgtgtaat  tatttttta  gaagagttt  tattatttt  tcatacggc  3000
gcagcagca  ctgccaggg  cttgggatt  tatttttgt  gcgggcggg  gtgggaggg  3060
cattttgtc  ctttgcctc  gttgagcat  taggaagta  taaaactgt  aagctttct  3120
agtgcactt  gaacctgga  aacaatccc  acaggcccg  gggaccatg  cttagggag  3180
tgggaccca  ccaccccca  ccaggaacc  tgacgtcca  ggaaccaaa  ccagacgca  3240
aacaataaa  taaattccg  actccccac  c  3271



<210> 1972
<211> 647
<212> PRT
<213> Homo sapiens
<308> P53667
<400> 1972

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Asp Cys Ser Ala Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu Gln Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Thr Cys Gly Thr Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly His Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ser His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro 
             260                265                270
Leu Ser Ser Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Arg Ser Pro Gly 
     290                295                300
Ala Gly Ser Leu Gly Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Lys Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Val Asp Glu Lys Thr Gln Pro Glu Gly Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Tyr Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu His Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Asp Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Gly Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 1973
<211> 3258
<212> DNA
<213> Rattus norvegicus
<308> D31873
<400> 1973

gcagcggca  cgcggagcc  gtgttcttc  agcctggtg  gggagtgca  cggagcatc  60
tcgccgaag  cggagcgga  cgctcggct  cggccccgc  ctccccgcc  cccgccttc  120
cgggccggc  gcgggcgag  tcgcgggcc  ggccccagc  ctccagtgc  ccgccggtt  180
ccggcggtc  ccgcccccc  ccgagtgca  gaggttgac  ctactttgt  gcacctgga  240
ggaagaacg  atgggagag  aaggaagcg  gttgcctgt  tgtgcgagc  gtagccaga  300
tatctatga  ggccagtac  tccaggccc  gaatgctga  tggcatgcg  attgcttca  360
gtgctgcga  tgtagcacc  ccctttcac  ccagtacta  gagaaggat  gacagctct  420
ctgcaagaa  gactactgg  cccgctatg  cgagtcttg  cacgggtgc  ccgaacaca  480
caccaaagg  ctggtcatg  tgggcgggg  gctgaagta  caccccgag  gcttcatct  540
ccttgcctg  ggaaacttc  tcggtgatg  ggacaccta  acactggtg  agcactcca  600
gctgtactg  gggcagtgc  actaccaga  tgtggtaac  ccagtcatc  aacagatcc  660
ccctgactc  cccggctcc  acctgcccc  cacagtcac  ctcgtgtct  tcccagcct  720
tgctcatgg  aaacgaggc  tgtctgtct  catcgaccc  cctcacggc  caccaggat  780
tggcacgga  cattcgcac  cggtccgag  ccaaggagt  gacccgggc  gcatgagcc  840
ggatgtgaa  aattccatc  acatcggag  caggatctt  gaaatcaac  gcacgccca  900
ccggaatgt  ccgctggac  agatcgact  gctgatcca  gagaccagc  gcctgctcc  960
gctgaccct  gagcacgac  cccatgact  actgggcca  gggccagtg  cggatccca  1020
ccccctggc  tccccggta  acactccca  cggacaggc  ggcagctct  cccggcaga  1080
acctgtctt  aggagctgc  gtattgaca  gtccccggg  gccggctca  tagtctcac  1140
agcctccca  cgcaaggac  tgggtcgct  cgaatccct  cgagtggtt  gtcgaccac  1200
ccgcatctt  cggccgtct  acctcatcc  tggggaggt  ttgggcaag  gctgtttcg  1260
ccaggccat  aaggtgaca  atcgagaaa  gggcgaggt  atggtgatg  aggaactca  1320
ccggtttga  gaggagacc  agaggacat  cctcaagga  gtgaaggtc  tgcgatgcc  1380
ggagcaccc  aacgtgctc  agttcatcg  cgtgctgta  aaggacaag  ggctgaact  1440
catcaccga  tacatcaag  gcggcaccc  gcggggcat  atcaagagc  tggacagcc  1500
gtacccgtg  agtcagagg  tcagctttg  caaggacat  gcatcaggg  tggcctacc  1560
ccattcgat  aacatcatc  accgagacc  caactccca  aactgtctg  tccgtgaga  1620
caggaacgt  gtggtggct  actttgggc  ggctcgact  atgatcgat  agaagggtc  1680
gtctgaaga  ttgcgtagc  ttaagaagc  ggaccgcaa  aaacggtac  cagtggtgg  1740
taaccccta  tggatggcg  cagagatga  caatggtcg  agttacgat  aaaaggtgg  1800
cgtgttttc  tttggaatt  tcctttgtg  gattatcgg  cgtgtgaat  cagaccctg  1860
ctatctgcc  cgcactatg  actttggcc  caatgtaag  ggtttcctg  accgctact  1920
tccaccaaa  tgtccccca  gtttcttcc  catcactgt  cgctgctgt  acctggatc  1980
tgagaagag  ccctctttt  taaagctgg  acaatggct  gaaacactt  gcatgcact  2040
ggctggtca  ctgccactg  gcccacaac  ggaacaact  gagcggggc  tctgggaga  2100
ctaccggcg  ggcgagagc  cgctacccg  ccaccccga  gtccctgac  gagcccagt  2160
ggcccacca  cttcatccc  gcctctgga  aatagaccc  caccagatt  ctcagcagg  2220
ggtggccta  gcatggagc  ctcagctgg  gcagtggtg  ccatatccg  acccccaga  2280
ctgcctttt  ccctcatgc  gggtgcccc  cagcctctc  ctgcctctg  cccccaagt  2340
acaaggctg  acacacacg  ggttggtca  atcgccctg  cttacctcc  attgtgtgg  2400
gccaccccc  cacttgtct  tgcatgagc  ggagggttg  ggaagctga  cccattcca  2460
gcaatgcct  cagctgtct  cacagcgca  ctgctggca  ctcttccca  caaggctgg  2520
ccagaaggc  gctttagaa  tgagccctg  aaggccaag  gagaggcta  gtgcccggg  2580
acccaaggg  agtccagga  cccttgggg  aaatctagg  agcatcagg  attgacagg  2640
atctaaatc  caaagcaga  agagagaga  gtccagtcc  atgtggcca  gcagtggcc  2700
tcgctcttg  ttcgtgtcc  tctcatttc  tgatcaaag  cactttagt  agaagtagg  2760
accagtcct  aggatgagc  aggagccct  aggggagag  gcggatgat  cctgggaac  2820
cagctgaca  ggagggtcc  gcccacacc  cagaggcta  gcagaggga  tgaggtagc  2880
atccaccag  accccagcc  tcccggttc  tctcagcac  cttcctggg  ctctccccg  2940
ggctggagc  gccccaccc  ctccctggg  gcatctgcc  tctgagttc  ttctgtgtg  3000
tctattttt  aagaagagt  tgttttgtt  ttttgtttt  ggtgggtgg  ggtgggagg  3060
ccatctctt  actctgctt  agttgaaca  ctagggacg  attaaaact  tgaagcttt  3120
tcagtgcac  ttgaacatg  aagagaatc  gaacccccg  gggaccagg  ctgaaagag  3180
caaggcctg  ttgcctcgg  ccagtgacc  tgataggaa  gaacccaaa  tcaataaaa  3240
caattctgt  ctcccccc  3258



<210> 1974
<211> 647
<212> PRT
<213> Rattus norvegicus
<308> P53669
<400> 1974

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Ser Gln Ser Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Glu Cys Ser Thr Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu His Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Gly Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Ala Cys Gly Asn Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly Gln Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ala His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Ile Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Ser Leu Gly His Gly Pro Val Ser Asp Pro Ser Pro 
             260                265                270
Leu Ala Ser Pro Val His Thr Pro Ser Gly Gln Ala Gly Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Thr Ser Pro Gly 
     290                295                300
Ala Gly Ser Leu Val Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Arg Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Ile Asp Glu Lys Gly Gln Ser Glu Asp Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu Gln Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Glu Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Ser Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 1975
<211> 3271
<212> DNA
<213> Homo sapiens
<308> NM_016735
<400> 1975

gcgccgagc  ggtttcccc  ccggtgtcc  agaggcgcc  ccggcccgg  ccggcccgg  60
ccgcgccct  cgcccccgc  tccccgggc  ggcggcggt  ggcgagctc  cgggcccgg  120
cgcccccag  cccagcccc  ccgggcccc  ccccccgtc  agtgcatga  gttgacgct  180
ctttgttgc  cctggaggg  agaacgtat  ggagaggaa  gaagcgagt  gcccgtgtg  240
gcaagctgc  gccagagga  ctatgatgg  cagtacctc  aggccctga  cgcggactg  300
cacgcagac  gcttcaggt  ttgtgactg  agtgcctcc  tgtcgcacc  gtactatga  360
aaggatggg  agctcttct  caagaagga  tactgggcc  gctatggcg  gtcctgcca  420
gggtgctct  agcaaatca  caagggact  gttatggtg  ctggggagc  gaagtacca  480
cccgagtgt  tcatctgcc  cacgtgtgg  acctttatc  gtgacgggg  cacctacac  540
ctggtggag  actccaagc  gtactgcgg  cactgctac  accagactg  ggtgacccc  600
gtcatcgag  agatcctgc  tgactcccc  ggctcccac  tgccccaca  cgtcaccct  660
gtgtccatc  cagcctcat  tcatggcaa  cgtggactt  cagtctcca  tgacccccc  720
cacggccca  cgggctgtg  caccgagca  tcacacacc  tccgcgtcc  gggagtgga  780
ccgggctgc  tgagcccag  tgtgaagaa  tccatccac  tcggagacc  gatcttgga  840
atcaatggc  cgcccatcc  aaatgtgcc  ctggacgag  ttgacctgc  gattcagga  900
accagccgc  tgctccagc  gaccctcga  catgaccct  acgatacac  gggccacgg  960
ctggggcct  agaccagcc  cctgagctc  ccggcttat  ctcccagcg  ggaggcggg  1020
agctctgcc  ggcagaaac  tgtcttcgc  aggacctgg  tcgctctga  tccctccgc  1080
tagtctgcc  gccacaccg  atcttccgg  cgtcggacc  catccacgg  gaggtgctg  1140
gcaagggct  cttcggcca  gctatcaag  tgacacacc  tgagacagg  gaggtgatg  1200
tgatgaagg  gctgatccg  ttcgacgag  agacccaga  gacgttcct  aaggaggtg  1260
aggtcatgc  atgcctgga  caccccaac  tgctcaagt  catcggggt  ctctacaag  1320
acaagaggc  caacttcat  actgagtac  tcaagggcg  cacgctccg  ggcatcatc  1380
agagcatgg  cagccagta  ccatggagc  agagagtga  ctttgccaa  gacatcgca  1440
cagggatgg  ctacctcca  tccatgaac  tcatccacc  agacctcaa  tcccacaac  1500
gcctggtcc  cgagaacaa  aatgtggtg  tggctgact  cgggctggc  cgtctcatg  1560
tggacgaga  gactcagcc  gagggcctg  ggagcctca  gaagccaga  cgcaagaag  1620
gctacaccg  ggtgggcaa  ccctactgg  tggcacctg  gatgatcaa  ggccgcagc  1680
atgatgaga  ggtggatgt  ttctccttt  ggatcgtcc  gtgcgagat  atcgggcgg  1740
tgaacgcag  ccctgacta  ctgccccgc  ccatggact  tggcctcaa  gtgcgagga  1800
tcctggacc  ctactgccc  ccaaactgc  ccccgagct  cttccccat  accgtgcgc  1860
gttgcgatc  ggaccccga  aagaggcca  cctttgtga  gctggaaca  tggctggag  1920
ccctccgca  gcacctggc  ggccacctg  cactgggcc  acagctgga  cagctggac  1980
gaggtttct  ggagaccta  cggcgcggc  agagcggac  gcctgccca  cctgaggtc  2040
ccgactgag  cagggccac  cagctgccc  tgtccccac  tctggagaa  ccaccccca  2100
cagattcct  cgcgggagg  ggccctcag  tgggacagt  gggacccag  cttctcctc  2160
gagccaggc  ctgacttgc  ttctcccac  ccgtggacc  cttcccctg  cttctctct  2220
ccgtggccc  gagccggcc  agctgcaca  acacaccat  ctctcgccc  gctgtaacc  2280
ctgtcttgg  agggctgtc  cctcttgct  ctccttgca  gagctggag  gcctgtgtg  2340
gttacgccc  tttccacac  ccgctgccc  agcaaccct  ttcacgctc  acctgtctg  2400
tccatagct  cctggaggc  gggccagga  gcagcctcc  aaccatgcc  catataacg  2460
ttgggtgcg  gggagggcg  acatcaggg  agaggccaa  ttccaggtg  ctgtgttcc  2520
aggaaccaa  tggggagtc  ggggcccgt  ttcccccca  ggggtgtct  ggtagcaac  2580
ggtatcgag  actctccaa  cccccaaag  agagagagg  ctgatccca  ggggcggag  2640
tccccagtg  ctgagcaaa  agccccttc  ctcgctttg  gtctttttt  tgtttcttt  2700
ttaaagcca  tttagtgag  agcaggtac  aagcctcag  gtgaagggg  tcccttgag  2760
gagcgtgga  ctgcggtgc  ctggccggc  atggggagg  gccggctcc  gcagtgaga  2820
gataggcac  gtggaccgg  caggtgtcc  ccagcagct  agcccctgc  gtcatctca  2880
agccccttc  cgggcctct  ccccaaggc  ccctgcccc  cctcatgcc  ctctgtcct  2940
tgcgttttt  ctgtgtaat  tatttttta  gaagagttt  tattatttt  tcatacggc  3000
gcagcagca  ctgccaggg  cttgggatt  tatttttgt  gcgggcggg  gtgggaggg  3060
cattttgtc  ctttgcctc  gttgagcat  taggaagta  taaaactgt  aagctttct  3120
agtgcactt  gaacctgga  aacaatccc  acaggcccg  gggaccatg  cttagggag  3180
tgggaccca  ccaccccca  ccaggaacc  tgacgtcca  ggaaccaaa  ccagacgca  3240
aacaataaa  taaattccg  actccccac  c  3271



<210> 1976
<211> 647
<212> PRT
<213> Homo sapiens
<308> P53667
<400> 1976

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Asp Cys Ser Ala Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu Gln Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Thr Cys Gly Thr Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly His Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ser His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro 
             260                265                270
Leu Ser Ser Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Arg Ser Pro Gly 
     290                295                300
Ala Gly Ser Leu Gly Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Lys Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Val Asp Glu Lys Thr Gln Pro Glu Gly Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Tyr Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu His Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Asp Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Gly Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 1977
<211> 3258
<212> DNA
<213> Rattus norvegicus
<308> D31873
<400> 1977

gcagcggca  cgcggagcc  gtgttcttc  agcctggtg  gggagtgca  cggagcatc  60
tcgccgaag  cggagcgga  cgctcggct  cggccccgc  ctccccgcc  cccgccttc  120
cgggccggc  gcgggcgag  tcgcgggcc  ggccccagc  ctccagtgc  ccgccggtt  180
ccggcggtc  ccgcccccc  ccgagtgca  gaggttgac  ctactttgt  gcacctgga  240
ggaagaacg  atgggagag  aaggaagcg  gttgcctgt  tgtgcgagc  gtagccaga  300
tatctatga  ggccagtac  tccaggccc  gaatgctga  tggcatgcg  attgcttca  360
gtgctgcga  tgtagcacc  ccctttcac  ccagtacta  gagaaggat  gacagctct  420
ctgcaagaa  gactactgg  cccgctatg  cgagtcttg  cacgggtgc  ccgaacaca  480
caccaaagg  ctggtcatg  tgggcgggg  gctgaagta  caccccgag  gcttcatct  540
ccttgcctg  ggaaacttc  tcggtgatg  ggacaccta  acactggtg  agcactcca  600
gctgtactg  gggcagtgc  actaccaga  tgtggtaac  ccagtcatc  aacagatcc  660
ccctgactc  cccggctcc  acctgcccc  cacagtcac  ctcgtgtct  tcccagcct  720
tgctcatgg  aaacgaggc  tgtctgtct  catcgaccc  cctcacggc  caccaggat  780
tggcacgga  cattcgcac  cggtccgag  ccaaggagt  gacccgggc  gcatgagcc  840
ggatgtgaa  aattccatc  acatcggag  caggatctt  gaaatcaac  gcacgccca  900
ccggaatgt  ccgctggac  agatcgact  gctgatcca  gagaccagc  gcctgctcc  960
gctgaccct  gagcacgac  cccatgact  actgggcca  gggccagtg  cggatccca  1020
ccccctggc  tccccggta  acactccca  cggacaggc  ggcagctct  cccggcaga  1080
acctgtctt  aggagctgc  gtattgaca  gtccccggg  gccggctca  tagtctcac  1140
agcctccca  cgcaaggac  tgggtcgct  cgaatccct  cgagtggtt  gtcgaccac  1200
ccgcatctt  cggccgtct  acctcatcc  tggggaggt  ttgggcaag  gctgtttcg  1260
ccaggccat  aaggtgaca  atcgagaaa  gggcgaggt  atggtgatg  aggaactca  1320
ccggtttga  gaggagacc  agaggacat  cctcaagga  gtgaaggtc  tgcgatgcc  1380
ggagcaccc  aacgtgctc  agttcatcg  cgtgctgta  aaggacaag  ggctgaact  1440
catcaccga  tacatcaag  gcggcaccc  gcggggcat  atcaagagc  tggacagcc  1500
gtacccgtg  agtcagagg  tcagctttg  caaggacat  gcatcaggg  tggcctacc  1560
ccattcgat  aacatcatc  accgagacc  caactccca  aactgtctg  tccgtgaga  1620
caggaacgt  gtggtggct  actttgggc  ggctcgact  atgatcgat  agaagggtc  1680
gtctgaaga  ttgcgtagc  ttaagaagc  ggaccgcaa  aaacggtac  cagtggtgg  1740
taaccccta  tggatggcg  cagagatga  caatggtcg  agttacgat  aaaaggtgg  1800
cgtgttttc  tttggaatt  tcctttgtg  gattatcgg  cgtgtgaat  cagaccctg  1860
ctatctgcc  cgcactatg  actttggcc  caatgtaag  ggtttcctg  accgctact  1920
tccaccaaa  tgtccccca  gtttcttcc  catcactgt  cgctgctgt  acctggatc  1980
tgagaagag  ccctctttt  taaagctgg  acaatggct  gaaacactt  gcatgcact  2040
ggctggtca  ctgccactg  gcccacaac  ggaacaact  gagcggggc  tctgggaga  2100
ctaccggcg  ggcgagagc  cgctacccg  ccaccccga  gtccctgac  gagcccagt  2160
ggcccacca  cttcatccc  gcctctgga  aatagaccc  caccagatt  ctcagcagg  2220
ggtggccta  gcatggagc  ctcagctgg  gcagtggtg  ccatatccg  acccccaga  2280
ctgcctttt  ccctcatgc  gggtgcccc  cagcctctc  ctgcctctg  cccccaagt  2340
acaaggctg  acacacacg  ggttggtca  atcgccctg  cttacctcc  attgtgtgg  2400
gccaccccc  cacttgtct  tgcatgagc  ggagggttg  ggaagctga  cccattcca  2460
gcaatgcct  cagctgtct  cacagcgca  ctgctggca  ctcttccca  caaggctgg  2520
ccagaaggc  gctttagaa  tgagccctg  aaggccaag  gagaggcta  gtgcccggg  2580
acccaaggg  agtccagga  cccttgggg  aaatctagg  agcatcagg  attgacagg  2640
atctaaatc  caaagcaga  agagagaga  gtccagtcc  atgtggcca  gcagtggcc  2700
tcgctcttg  ttcgtgtcc  tctcatttc  tgatcaaag  cactttagt  agaagtagg  2760
accagtcct  aggatgagc  aggagccct  aggggagag  gcggatgat  cctgggaac  2820
cagctgaca  ggagggtcc  gcccacacc  cagaggcta  gcagaggga  tgaggtagc  2880
atccaccag  accccagcc  tcccggttc  tctcagcac  cttcctggg  ctctccccg  2940
ggctggagc  gccccaccc  ctccctggg  gcatctgcc  tctgagttc  ttctgtgtg  3000
tctattttt  aagaagagt  tgttttgtt  ttttgtttt  ggtgggtgg  ggtgggagg  3060
ccatctctt  actctgctt  agttgaaca  ctagggacg  attaaaact  tgaagcttt  3120
tcagtgcac  ttgaacatg  aagagaatc  gaacccccg  gggaccagg  ctgaaagag  3180
caaggcctg  ttgcctcgg  ccagtgacc  tgataggaa  gaacccaaa  tcaataaaa  3240
caattctgt  ctcccccc  3258



<210> 1978
<211> 647
<212> PRT
<213> Rattus norvegicus
<308> P53669
<400> 1978

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Ser Gln Ser Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Glu Cys Ser Thr Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu His Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Gly Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Ala Cys Gly Asn Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly Gln Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ala His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Ile Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Ser Leu Gly His Gly Pro Val Ser Asp Pro Ser Pro 
             260                265                270
Leu Ala Ser Pro Val His Thr Pro Ser Gly Gln Ala Gly Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Thr Ser Pro Gly 
     290                295                300
Ala Gly Ser Leu Val Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Arg Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Ile Asp Glu Lys Gly Gln Ser Glu Asp Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu Gln Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Glu Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Ser Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 1979
<211> 3271
<212> DNA
<213> Homo sapiens
<308> NM_016735
<400> 1979

gcgccgagc  ggtttcccc  ccggtgtcc  agaggcgcc  ccggcccgg  ccggcccgg  60
ccgcgccct  cgcccccgc  tccccgggc  ggcggcggt  ggcgagctc  cgggcccgg  120
cgcccccag  cccagcccc  ccgggcccc  ccccccgtc  agtgcatga  gttgacgct  180
ctttgttgc  cctggaggg  agaacgtat  ggagaggaa  gaagcgagt  gcccgtgtg  240
gcaagctgc  gccagagga  ctatgatgg  cagtacctc  aggccctga  cgcggactg  300
cacgcagac  gcttcaggt  ttgtgactg  agtgcctcc  tgtcgcacc  gtactatga  360
aaggatggg  agctcttct  caagaagga  tactgggcc  gctatggcg  gtcctgcca  420
gggtgctct  agcaaatca  caagggact  gttatggtg  ctggggagc  gaagtacca  480
cccgagtgt  tcatctgcc  cacgtgtgg  acctttatc  gtgacgggg  cacctacac  540
ctggtggag  actccaagc  gtactgcgg  cactgctac  accagactg  ggtgacccc  600
gtcatcgag  agatcctgc  tgactcccc  ggctcccac  tgccccaca  cgtcaccct  660
gtgtccatc  cagcctcat  tcatggcaa  cgtggactt  cagtctcca  tgacccccc  720
cacggccca  cgggctgtg  caccgagca  tcacacacc  tccgcgtcc  gggagtgga  780
ccgggctgc  tgagcccag  tgtgaagaa  tccatccac  tcggagacc  gatcttgga  840
atcaatggc  cgcccatcc  aaatgtgcc  ctggacgag  ttgacctgc  gattcagga  900
accagccgc  tgctccagc  gaccctcga  catgaccct  acgatacac  gggccacgg  960
ctggggcct  agaccagcc  cctgagctc  ccggcttat  ctcccagcg  ggaggcggg  1020
agctctgcc  ggcagaaac  tgtcttcgc  aggacctgg  tcgctctga  tccctccgc  1080
tagtctgcc  gccacaccg  atcttccgg  cgtcggacc  catccacgg  gaggtgctg  1140
gcaagggct  cttcggcca  gctatcaag  tgacacacc  tgagacagg  gaggtgatg  1200
tgatgaagg  gctgatccg  ttcgacgag  agacccaga  gacgttcct  aaggaggtg  1260
aggtcatgc  atgcctgga  caccccaac  tgctcaagt  catcggggt  ctctacaag  1320
acaagaggc  caacttcat  actgagtac  tcaagggcg  cacgctccg  ggcatcatc  1380
agagcatgg  cagccagta  ccatggagc  agagagtga  ctttgccaa  gacatcgca  1440
cagggatgg  ctacctcca  tccatgaac  tcatccacc  agacctcaa  tcccacaac  1500
gcctggtcc  cgagaacaa  aatgtggtg  tggctgact  cgggctggc  cgtctcatg  1560
tggacgaga  gactcagcc  gagggcctg  ggagcctca  gaagccaga  cgcaagaag  1620
gctacaccg  ggtgggcaa  ccctactgg  tggcacctg  gatgatcaa  ggccgcagc  1680
atgatgaga  ggtggatgt  ttctccttt  ggatcgtcc  gtgcgagat  atcgggcgg  1740
tgaacgcag  ccctgacta  ctgccccgc  ccatggact  tggcctcaa  gtgcgagga  1800
tcctggacc  ctactgccc  ccaaactgc  ccccgagct  cttccccat  accgtgcgc  1860
gttgcgatc  ggaccccga  aagaggcca  cctttgtga  gctggaaca  tggctggag  1920
ccctccgca  gcacctggc  ggccacctg  cactgggcc  acagctgga  cagctggac  1980
gaggtttct  ggagaccta  cggcgcggc  agagcggac  gcctgccca  cctgaggtc  2040
ccgactgag  cagggccac  cagctgccc  tgtccccac  tctggagaa  ccaccccca  2100
cagattcct  cgcgggagg  ggccctcag  tgggacagt  gggacccag  cttctcctc  2160
gagccaggc  ctgacttgc  ttctcccac  ccgtggacc  cttcccctg  cttctctct  2220
ccgtggccc  gagccggcc  agctgcaca  acacaccat  ctctcgccc  gctgtaacc  2280
ctgtcttgg  agggctgtc  cctcttgct  ctccttgca  gagctggag  gcctgtgtg  2340
gttacgccc  tttccacac  ccgctgccc  agcaaccct  ttcacgctc  acctgtctg  2400
tccatagct  cctggaggc  gggccagga  gcagcctcc  aaccatgcc  catataacg  2460
ttgggtgcg  gggagggcg  acatcaggg  agaggccaa  ttccaggtg  ctgtgttcc  2520
aggaaccaa  tggggagtc  ggggcccgt  ttcccccca  ggggtgtct  ggtagcaac  2580
ggtatcgag  actctccaa  cccccaaag  agagagagg  ctgatccca  ggggcggag  2640
tccccagtg  ctgagcaaa  agccccttc  ctcgctttg  gtctttttt  tgtttcttt  2700
ttaaagcca  tttagtgag  agcaggtac  aagcctcag  gtgaagggg  tcccttgag  2760
gagcgtgga  ctgcggtgc  ctggccggc  atggggagg  gccggctcc  gcagtgaga  2820
gataggcac  gtggaccgg  caggtgtcc  ccagcagct  agcccctgc  gtcatctca  2880
agccccttc  cgggcctct  ccccaaggc  ccctgcccc  cctcatgcc  ctctgtcct  2940
tgcgttttt  ctgtgtaat  tatttttta  gaagagttt  tattatttt  tcatacggc  3000
gcagcagca  ctgccaggg  cttgggatt  tatttttgt  gcgggcggg  gtgggaggg  3060
cattttgtc  ctttgcctc  gttgagcat  taggaagta  taaaactgt  aagctttct  3120
agtgcactt  gaacctgga  aacaatccc  acaggcccg  gggaccatg  cttagggag  3180
tgggaccca  ccaccccca  ccaggaacc  tgacgtcca  ggaaccaaa  ccagacgca  3240
aacaataaa  taaattccg  actccccac  c  3271



<210> 1980
<211> 647
<212> PRT
<213> Homo sapiens
<308> P53667
<400> 1980

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Asp Cys Ser Ala Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu Gln Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Thr Cys Gly Thr Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly His Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ser His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro 
             260                265                270
Leu Ser Ser Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Arg Ser Pro Gly 
     290                295                300
Ala Gly Ser Leu Gly Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Lys Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Val Asp Glu Lys Thr Gln Pro Glu Gly Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Tyr Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu His Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Asp Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Gly Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 1981
<211> 3258
<212> DNA
<213> Rattus norvegicus
<308> D31873
<400> 1981

gcagcggca  cgcggagcc  gtgttcttc  agcctggtg  gggagtgca  cggagcatc  60
tcgccgaag  cggagcgga  cgctcggct  cggccccgc  ctccccgcc  cccgccttc  120
cgggccggc  gcgggcgag  tcgcgggcc  ggccccagc  ctccagtgc  ccgccggtt  180
ccggcggtc  ccgcccccc  ccgagtgca  gaggttgac  ctactttgt  gcacctgga  240
ggaagaacg  atgggagag  aaggaagcg  gttgcctgt  tgtgcgagc  gtagccaga  300
tatctatga  ggccagtac  tccaggccc  gaatgctga  tggcatgcg  attgcttca  360
gtgctgcga  tgtagcacc  ccctttcac  ccagtacta  gagaaggat  gacagctct  420
ctgcaagaa  gactactgg  cccgctatg  cgagtcttg  cacgggtgc  ccgaacaca  480
caccaaagg  ctggtcatg  tgggcgggg  gctgaagta  caccccgag  gcttcatct  540
ccttgcctg  ggaaacttc  tcggtgatg  ggacaccta  acactggtg  agcactcca  600
gctgtactg  gggcagtgc  actaccaga  tgtggtaac  ccagtcatc  aacagatcc  660
ccctgactc  cccggctcc  acctgcccc  cacagtcac  ctcgtgtct  tcccagcct  720
tgctcatgg  aaacgaggc  tgtctgtct  catcgaccc  cctcacggc  caccaggat  780
tggcacgga  cattcgcac  cggtccgag  ccaaggagt  gacccgggc  gcatgagcc  840
ggatgtgaa  aattccatc  acatcggag  caggatctt  gaaatcaac  gcacgccca  900
ccggaatgt  ccgctggac  agatcgact  gctgatcca  gagaccagc  gcctgctcc  960
gctgaccct  gagcacgac  cccatgact  actgggcca  gggccagtg  cggatccca  1020
ccccctggc  tccccggta  acactccca  cggacaggc  ggcagctct  cccggcaga  1080
acctgtctt  aggagctgc  gtattgaca  gtccccggg  gccggctca  tagtctcac  1140
agcctccca  cgcaaggac  tgggtcgct  cgaatccct  cgagtggtt  gtcgaccac  1200
ccgcatctt  cggccgtct  acctcatcc  tggggaggt  ttgggcaag  gctgtttcg  1260
ccaggccat  aaggtgaca  atcgagaaa  gggcgaggt  atggtgatg  aggaactca  1320
ccggtttga  gaggagacc  agaggacat  cctcaagga  gtgaaggtc  tgcgatgcc  1380
ggagcaccc  aacgtgctc  agttcatcg  cgtgctgta  aaggacaag  ggctgaact  1440
catcaccga  tacatcaag  gcggcaccc  gcggggcat  atcaagagc  tggacagcc  1500
gtacccgtg  agtcagagg  tcagctttg  caaggacat  gcatcaggg  tggcctacc  1560
ccattcgat  aacatcatc  accgagacc  caactccca  aactgtctg  tccgtgaga  1620
caggaacgt  gtggtggct  actttgggc  ggctcgact  atgatcgat  agaagggtc  1680
gtctgaaga  ttgcgtagc  ttaagaagc  ggaccgcaa  aaacggtac  cagtggtgg  1740
taaccccta  tggatggcg  cagagatga  caatggtcg  agttacgat  aaaaggtgg  1800
cgtgttttc  tttggaatt  tcctttgtg  gattatcgg  cgtgtgaat  cagaccctg  1860
ctatctgcc  cgcactatg  actttggcc  caatgtaag  ggtttcctg  accgctact  1920
tccaccaaa  tgtccccca  gtttcttcc  catcactgt  cgctgctgt  acctggatc  1980
tgagaagag  ccctctttt  taaagctgg  acaatggct  gaaacactt  gcatgcact  2040
ggctggtca  ctgccactg  gcccacaac  ggaacaact  gagcggggc  tctgggaga  2100
ctaccggcg  ggcgagagc  cgctacccg  ccaccccga  gtccctgac  gagcccagt  2160
ggcccacca  cttcatccc  gcctctgga  aatagaccc  caccagatt  ctcagcagg  2220
ggtggccta  gcatggagc  ctcagctgg  gcagtggtg  ccatatccg  acccccaga  2280
ctgcctttt  ccctcatgc  gggtgcccc  cagcctctc  ctgcctctg  cccccaagt  2340
acaaggctg  acacacacg  ggttggtca  atcgccctg  cttacctcc  attgtgtgg  2400
gccaccccc  cacttgtct  tgcatgagc  ggagggttg  ggaagctga  cccattcca  2460
gcaatgcct  cagctgtct  cacagcgca  ctgctggca  ctcttccca  caaggctgg  2520
ccagaaggc  gctttagaa  tgagccctg  aaggccaag  gagaggcta  gtgcccggg  2580
acccaaggg  agtccagga  cccttgggg  aaatctagg  agcatcagg  attgacagg  2640
atctaaatc  caaagcaga  agagagaga  gtccagtcc  atgtggcca  gcagtggcc  2700
tcgctcttg  ttcgtgtcc  tctcatttc  tgatcaaag  cactttagt  agaagtagg  2760
accagtcct  aggatgagc  aggagccct  aggggagag  gcggatgat  cctgggaac  2820
cagctgaca  ggagggtcc  gcccacacc  cagaggcta  gcagaggga  tgaggtagc  2880
atccaccag  accccagcc  tcccggttc  tctcagcac  cttcctggg  ctctccccg  2940
ggctggagc  gccccaccc  ctccctggg  gcatctgcc  tctgagttc  ttctgtgtg  3000
tctattttt  aagaagagt  tgttttgtt  ttttgtttt  ggtgggtgg  ggtgggagg  3060
ccatctctt  actctgctt  agttgaaca  ctagggacg  attaaaact  tgaagcttt  3120
tcagtgcac  ttgaacatg  aagagaatc  gaacccccg  gggaccagg  ctgaaagag  3180
caaggcctg  ttgcctcgg  ccagtgacc  tgataggaa  gaacccaaa  tcaataaaa  3240
caattctgt  ctcccccc  3258



<210> 1982
<211> 647
<212> PRT
<213> Rattus norvegicus
<308> P53669
<400> 1982

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Ser Gln Ser Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Glu Cys Ser Thr Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu His Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Gly Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Ala Cys Gly Asn Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly Gln Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ala His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Ile Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Ser Leu Gly His Gly Pro Val Ser Asp Pro Ser Pro 
             260                265                270
Leu Ala Ser Pro Val His Thr Pro Ser Gly Gln Ala Gly Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Thr Ser Pro Gly 
     290                295                300
Ala Gly Ser Leu Val Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Arg Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Ile Asp Glu Lys Gly Gln Ser Glu Asp Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu Gln Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Glu Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Ser Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 1983
<211> 3271
<212> DNA
<213> Homo sapiens
<308> NM_016735
<400> 1983

gcgccgagc  ggtttcccc  ccggtgtcc  agaggcgcc  ccggcccgg  ccggcccgg  60
ccgcgccct  cgcccccgc  tccccgggc  ggcggcggt  ggcgagctc  cgggcccgg  120
cgcccccag  cccagcccc  ccgggcccc  ccccccgtc  agtgcatga  gttgacgct  180
ctttgttgc  cctggaggg  agaacgtat  ggagaggaa  gaagcgagt  gcccgtgtg  240
gcaagctgc  gccagagga  ctatgatgg  cagtacctc  aggccctga  cgcggactg  300
cacgcagac  gcttcaggt  ttgtgactg  agtgcctcc  tgtcgcacc  gtactatga  360
aaggatggg  agctcttct  caagaagga  tactgggcc  gctatggcg  gtcctgcca  420
gggtgctct  agcaaatca  caagggact  gttatggtg  ctggggagc  gaagtacca  480
cccgagtgt  tcatctgcc  cacgtgtgg  acctttatc  gtgacgggg  cacctacac  540
ctggtggag  actccaagc  gtactgcgg  cactgctac  accagactg  ggtgacccc  600
gtcatcgag  agatcctgc  tgactcccc  ggctcccac  tgccccaca  cgtcaccct  660
gtgtccatc  cagcctcat  tcatggcaa  cgtggactt  cagtctcca  tgacccccc  720
cacggccca  cgggctgtg  caccgagca  tcacacacc  tccgcgtcc  gggagtgga  780
ccgggctgc  tgagcccag  tgtgaagaa  tccatccac  tcggagacc  gatcttgga  840
atcaatggc  cgcccatcc  aaatgtgcc  ctggacgag  ttgacctgc  gattcagga  900
accagccgc  tgctccagc  gaccctcga  catgaccct  acgatacac  gggccacgg  960
ctggggcct  agaccagcc  cctgagctc  ccggcttat  ctcccagcg  ggaggcggg  1020
agctctgcc  ggcagaaac  tgtcttcgc  aggacctgg  tcgctctga  tccctccgc  1080
tagtctgcc  gccacaccg  atcttccgg  cgtcggacc  catccacgg  gaggtgctg  1140
gcaagggct  cttcggcca  gctatcaag  tgacacacc  tgagacagg  gaggtgatg  1200
tgatgaagg  gctgatccg  ttcgacgag  agacccaga  gacgttcct  aaggaggtg  1260
aggtcatgc  atgcctgga  caccccaac  tgctcaagt  catcggggt  ctctacaag  1320
acaagaggc  caacttcat  actgagtac  tcaagggcg  cacgctccg  ggcatcatc  1380
agagcatgg  cagccagta  ccatggagc  agagagtga  ctttgccaa  gacatcgca  1440
cagggatgg  ctacctcca  tccatgaac  tcatccacc  agacctcaa  tcccacaac  1500
gcctggtcc  cgagaacaa  aatgtggtg  tggctgact  cgggctggc  cgtctcatg  1560
tggacgaga  gactcagcc  gagggcctg  ggagcctca  gaagccaga  cgcaagaag  1620
gctacaccg  ggtgggcaa  ccctactgg  tggcacctg  gatgatcaa  ggccgcagc  1680
atgatgaga  ggtggatgt  ttctccttt  ggatcgtcc  gtgcgagat  atcgggcgg  1740
tgaacgcag  ccctgacta  ctgccccgc  ccatggact  tggcctcaa  gtgcgagga  1800
tcctggacc  ctactgccc  ccaaactgc  ccccgagct  cttccccat  accgtgcgc  1860
gttgcgatc  ggaccccga  aagaggcca  cctttgtga  gctggaaca  tggctggag  1920
ccctccgca  gcacctggc  ggccacctg  cactgggcc  acagctgga  cagctggac  1980
gaggtttct  ggagaccta  cggcgcggc  agagcggac  gcctgccca  cctgaggtc  2040
ccgactgag  cagggccac  cagctgccc  tgtccccac  tctggagaa  ccaccccca  2100
cagattcct  cgcgggagg  ggccctcag  tgggacagt  gggacccag  cttctcctc  2160
gagccaggc  ctgacttgc  ttctcccac  ccgtggacc  cttcccctg  cttctctct  2220
ccgtggccc  gagccggcc  agctgcaca  acacaccat  ctctcgccc  gctgtaacc  2280
ctgtcttgg  agggctgtc  cctcttgct  ctccttgca  gagctggag  gcctgtgtg  2340
gttacgccc  tttccacac  ccgctgccc  agcaaccct  ttcacgctc  acctgtctg  2400
tccatagct  cctggaggc  gggccagga  gcagcctcc  aaccatgcc  catataacg  2460
ttgggtgcg  gggagggcg  acatcaggg  agaggccaa  ttccaggtg  ctgtgttcc  2520
aggaaccaa  tggggagtc  ggggcccgt  ttcccccca  ggggtgtct  ggtagcaac  2580
ggtatcgag  actctccaa  cccccaaag  agagagagg  ctgatccca  ggggcggag  2640
tccccagtg  ctgagcaaa  agccccttc  ctcgctttg  gtctttttt  tgtttcttt  2700
ttaaagcca  tttagtgag  agcaggtac  aagcctcag  gtgaagggg  tcccttgag  2760
gagcgtgga  ctgcggtgc  ctggccggc  atggggagg  gccggctcc  gcagtgaga  2820
gataggcac  gtggaccgg  caggtgtcc  ccagcagct  agcccctgc  gtcatctca  2880
agccccttc  cgggcctct  ccccaaggc  ccctgcccc  cctcatgcc  ctctgtcct  2940
tgcgttttt  ctgtgtaat  tatttttta  gaagagttt  tattatttt  tcatacggc  3000
gcagcagca  ctgccaggg  cttgggatt  tatttttgt  gcgggcggg  gtgggaggg  3060
cattttgtc  ctttgcctc  gttgagcat  taggaagta  taaaactgt  aagctttct  3120
agtgcactt  gaacctgga  aacaatccc  acaggcccg  gggaccatg  cttagggag  3180
tgggaccca  ccaccccca  ccaggaacc  tgacgtcca  ggaaccaaa  ccagacgca  3240
aacaataaa  taaattccg  actccccac  c  3271



<210> 1984
<211> 647
<212> PRT
<213> Homo sapiens
<308> P53667
<400> 1984

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Asp Cys Ser Ala Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu Gln Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Thr Cys Gly Thr Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly His Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ser His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro 
             260                265                270
Leu Ser Ser Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Arg Ser Pro Gly 
     290                295                300
Ala Gly Ser Leu Gly Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Lys Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Val Asp Glu Lys Thr Gln Pro Glu Gly Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Tyr Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu His Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Asp Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Gly Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 1985
<211> 3258
<212> DNA
<213> Rattus norvegicus
<308> D31873
<400> 1985

gcagcggca  cgcggagcc  gtgttcttc  agcctggtg  gggagtgca  cggagcatc  60
tcgccgaag  cggagcgga  cgctcggct  cggccccgc  ctccccgcc  cccgccttc  120
cgggccggc  gcgggcgag  tcgcgggcc  ggccccagc  ctccagtgc  ccgccggtt  180
ccggcggtc  ccgcccccc  ccgagtgca  gaggttgac  ctactttgt  gcacctgga  240
ggaagaacg  atgggagag  aaggaagcg  gttgcctgt  tgtgcgagc  gtagccaga  300
tatctatga  ggccagtac  tccaggccc  gaatgctga  tggcatgcg  attgcttca  360
gtgctgcga  tgtagcacc  ccctttcac  ccagtacta  gagaaggat  gacagctct  420
ctgcaagaa  gactactgg  cccgctatg  cgagtcttg  cacgggtgc  ccgaacaca  480
caccaaagg  ctggtcatg  tgggcgggg  gctgaagta  caccccgag  gcttcatct  540
ccttgcctg  ggaaacttc  tcggtgatg  ggacaccta  acactggtg  agcactcca  600
gctgtactg  gggcagtgc  actaccaga  tgtggtaac  ccagtcatc  aacagatcc  660
ccctgactc  cccggctcc  acctgcccc  cacagtcac  ctcgtgtct  tcccagcct  720
tgctcatgg  aaacgaggc  tgtctgtct  catcgaccc  cctcacggc  caccaggat  780
tggcacgga  cattcgcac  cggtccgag  ccaaggagt  gacccgggc  gcatgagcc  840
ggatgtgaa  aattccatc  acatcggag  caggatctt  gaaatcaac  gcacgccca  900
ccggaatgt  ccgctggac  agatcgact  gctgatcca  gagaccagc  gcctgctcc  960
gctgaccct  gagcacgac  cccatgact  actgggcca  gggccagtg  cggatccca  1020
ccccctggc  tccccggta  acactccca  cggacaggc  ggcagctct  cccggcaga  1080
acctgtctt  aggagctgc  gtattgaca  gtccccggg  gccggctca  tagtctcac  1140
agcctccca  cgcaaggac  tgggtcgct  cgaatccct  cgagtggtt  gtcgaccac  1200
ccgcatctt  cggccgtct  acctcatcc  tggggaggt  ttgggcaag  gctgtttcg  1260
ccaggccat  aaggtgaca  atcgagaaa  gggcgaggt  atggtgatg  aggaactca  1320
ccggtttga  gaggagacc  agaggacat  cctcaagga  gtgaaggtc  tgcgatgcc  1380
ggagcaccc  aacgtgctc  agttcatcg  cgtgctgta  aaggacaag  ggctgaact  1440
catcaccga  tacatcaag  gcggcaccc  gcggggcat  atcaagagc  tggacagcc  1500
gtacccgtg  agtcagagg  tcagctttg  caaggacat  gcatcaggg  tggcctacc  1560
ccattcgat  aacatcatc  accgagacc  caactccca  aactgtctg  tccgtgaga  1620
caggaacgt  gtggtggct  actttgggc  ggctcgact  atgatcgat  agaagggtc  1680
gtctgaaga  ttgcgtagc  ttaagaagc  ggaccgcaa  aaacggtac  cagtggtgg  1740
taaccccta  tggatggcg  cagagatga  caatggtcg  agttacgat  aaaaggtgg  1800
cgtgttttc  tttggaatt  tcctttgtg  gattatcgg  cgtgtgaat  cagaccctg  1860
ctatctgcc  cgcactatg  actttggcc  caatgtaag  ggtttcctg  accgctact  1920
tccaccaaa  tgtccccca  gtttcttcc  catcactgt  cgctgctgt  acctggatc  1980
tgagaagag  ccctctttt  taaagctgg  acaatggct  gaaacactt  gcatgcact  2040
ggctggtca  ctgccactg  gcccacaac  ggaacaact  gagcggggc  tctgggaga  2100
ctaccggcg  ggcgagagc  cgctacccg  ccaccccga  gtccctgac  gagcccagt  2160
ggcccacca  cttcatccc  gcctctgga  aatagaccc  caccagatt  ctcagcagg  2220
ggtggccta  gcatggagc  ctcagctgg  gcagtggtg  ccatatccg  acccccaga  2280
ctgcctttt  ccctcatgc  gggtgcccc  cagcctctc  ctgcctctg  cccccaagt  2340
acaaggctg  acacacacg  ggttggtca  atcgccctg  cttacctcc  attgtgtgg  2400
gccaccccc  cacttgtct  tgcatgagc  ggagggttg  ggaagctga  cccattcca  2460
gcaatgcct  cagctgtct  cacagcgca  ctgctggca  ctcttccca  caaggctgg  2520
ccagaaggc  gctttagaa  tgagccctg  aaggccaag  gagaggcta  gtgcccggg  2580
acccaaggg  agtccagga  cccttgggg  aaatctagg  agcatcagg  attgacagg  2640
atctaaatc  caaagcaga  agagagaga  gtccagtcc  atgtggcca  gcagtggcc  2700
tcgctcttg  ttcgtgtcc  tctcatttc  tgatcaaag  cactttagt  agaagtagg  2760
accagtcct  aggatgagc  aggagccct  aggggagag  gcggatgat  cctgggaac  2820
cagctgaca  ggagggtcc  gcccacacc  cagaggcta  gcagaggga  tgaggtagc  2880
atccaccag  accccagcc  tcccggttc  tctcagcac  cttcctggg  ctctccccg  2940
ggctggagc  gccccaccc  ctccctggg  gcatctgcc  tctgagttc  ttctgtgtg  3000
tctattttt  aagaagagt  tgttttgtt  ttttgtttt  ggtgggtgg  ggtgggagg  3060
ccatctctt  actctgctt  agttgaaca  ctagggacg  attaaaact  tgaagcttt  3120
tcagtgcac  ttgaacatg  aagagaatc  gaacccccg  gggaccagg  ctgaaagag  3180
caaggcctg  ttgcctcgg  ccagtgacc  tgataggaa  gaacccaaa  tcaataaaa  3240
caattctgt  ctcccccc  3258



<210> 1986
<211> 647
<212> PRT
<213> Rattus norvegicus
<308> P53669
<400> 1986

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Ser Gln Ser Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Glu Cys Ser Thr Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu His Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Gly Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Ala Cys Gly Asn Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly Gln Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ala His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Ile Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Ser Leu Gly His Gly Pro Val Ser Asp Pro Ser Pro 
             260                265                270
Leu Ala Ser Pro Val His Thr Pro Ser Gly Gln Ala Gly Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Thr Ser Pro Gly 
     290                295                300
Ala Gly Ser Leu Val Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Arg Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Ile Asp Glu Lys Gly Gln Ser Glu Asp Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu Gln Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Glu Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Ser Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 1987
<211> 3271
<212> DNA
<213> Homo sapiens
<308> NM_016735
<400> 1987

gcgccgagc  ggtttcccc  ccggtgtcc  agaggcgcc  ccggcccgg  ccggcccgg  60
ccgcgccct  cgcccccgc  tccccgggc  ggcggcggt  ggcgagctc  cgggcccgg  120
cgcccccag  cccagcccc  ccgggcccc  ccccccgtc  agtgcatga  gttgacgct  180
ctttgttgc  cctggaggg  agaacgtat  ggagaggaa  gaagcgagt  gcccgtgtg  240
gcaagctgc  gccagagga  ctatgatgg  cagtacctc  aggccctga  cgcggactg  300
cacgcagac  gcttcaggt  ttgtgactg  agtgcctcc  tgtcgcacc  gtactatga  360
aaggatggg  agctcttct  caagaagga  tactgggcc  gctatggcg  gtcctgcca  420
gggtgctct  agcaaatca  caagggact  gttatggtg  ctggggagc  gaagtacca  480
cccgagtgt  tcatctgcc  cacgtgtgg  acctttatc  gtgacgggg  cacctacac  540
ctggtggag  actccaagc  gtactgcgg  cactgctac  accagactg  ggtgacccc  600
gtcatcgag  agatcctgc  tgactcccc  ggctcccac  tgccccaca  cgtcaccct  660
gtgtccatc  cagcctcat  tcatggcaa  cgtggactt  cagtctcca  tgacccccc  720
cacggccca  cgggctgtg  caccgagca  tcacacacc  tccgcgtcc  gggagtgga  780
ccgggctgc  tgagcccag  tgtgaagaa  tccatccac  tcggagacc  gatcttgga  840
atcaatggc  cgcccatcc  aaatgtgcc  ctggacgag  ttgacctgc  gattcagga  900
accagccgc  tgctccagc  gaccctcga  catgaccct  acgatacac  gggccacgg  960
ctggggcct  agaccagcc  cctgagctc  ccggcttat  ctcccagcg  ggaggcggg  1020
agctctgcc  ggcagaaac  tgtcttcgc  aggacctgg  tcgctctga  tccctccgc  1080
tagtctgcc  gccacaccg  atcttccgg  cgtcggacc  catccacgg  gaggtgctg  1140
gcaagggct  cttcggcca  gctatcaag  tgacacacc  tgagacagg  gaggtgatg  1200
tgatgaagg  gctgatccg  ttcgacgag  agacccaga  gacgttcct  aaggaggtg  1260
aggtcatgc  atgcctgga  caccccaac  tgctcaagt  catcggggt  ctctacaag  1320
acaagaggc  caacttcat  actgagtac  tcaagggcg  cacgctccg  ggcatcatc  1380
agagcatgg  cagccagta  ccatggagc  agagagtga  ctttgccaa  gacatcgca  1440
cagggatgg  ctacctcca  tccatgaac  tcatccacc  agacctcaa  tcccacaac  1500
gcctggtcc  cgagaacaa  aatgtggtg  tggctgact  cgggctggc  cgtctcatg  1560
tggacgaga  gactcagcc  gagggcctg  ggagcctca  gaagccaga  cgcaagaag  1620
gctacaccg  ggtgggcaa  ccctactgg  tggcacctg  gatgatcaa  ggccgcagc  1680
atgatgaga  ggtggatgt  ttctccttt  ggatcgtcc  gtgcgagat  atcgggcgg  1740
tgaacgcag  ccctgacta  ctgccccgc  ccatggact  tggcctcaa  gtgcgagga  1800
tcctggacc  ctactgccc  ccaaactgc  ccccgagct  cttccccat  accgtgcgc  1860
gttgcgatc  ggaccccga  aagaggcca  cctttgtga  gctggaaca  tggctggag  1920
ccctccgca  gcacctggc  ggccacctg  cactgggcc  acagctgga  cagctggac  1980
gaggtttct  ggagaccta  cggcgcggc  agagcggac  gcctgccca  cctgaggtc  2040
ccgactgag  cagggccac  cagctgccc  tgtccccac  tctggagaa  ccaccccca  2100
cagattcct  cgcgggagg  ggccctcag  tgggacagt  gggacccag  cttctcctc  2160
gagccaggc  ctgacttgc  ttctcccac  ccgtggacc  cttcccctg  cttctctct  2220
ccgtggccc  gagccggcc  agctgcaca  acacaccat  ctctcgccc  gctgtaacc  2280
ctgtcttgg  agggctgtc  cctcttgct  ctccttgca  gagctggag  gcctgtgtg  2340
gttacgccc  tttccacac  ccgctgccc  agcaaccct  ttcacgctc  acctgtctg  2400
tccatagct  cctggaggc  gggccagga  gcagcctcc  aaccatgcc  catataacg  2460
ttgggtgcg  gggagggcg  acatcaggg  agaggccaa  ttccaggtg  ctgtgttcc  2520
aggaaccaa  tggggagtc  ggggcccgt  ttcccccca  ggggtgtct  ggtagcaac  2580
ggtatcgag  actctccaa  cccccaaag  agagagagg  ctgatccca  ggggcggag  2640
tccccagtg  ctgagcaaa  agccccttc  ctcgctttg  gtctttttt  tgtttcttt  2700
ttaaagcca  tttagtgag  agcaggtac  aagcctcag  gtgaagggg  tcccttgag  2760
gagcgtgga  ctgcggtgc  ctggccggc  atggggagg  gccggctcc  gcagtgaga  2820
gataggcac  gtggaccgg  caggtgtcc  ccagcagct  agcccctgc  gtcatctca  2880
agccccttc  cgggcctct  ccccaaggc  ccctgcccc  cctcatgcc  ctctgtcct  2940
tgcgttttt  ctgtgtaat  tatttttta  gaagagttt  tattatttt  tcatacggc  3000
gcagcagca  ctgccaggg  cttgggatt  tatttttgt  gcgggcggg  gtgggaggg  3060
cattttgtc  ctttgcctc  gttgagcat  taggaagta  taaaactgt  aagctttct  3120
agtgcactt  gaacctgga  aacaatccc  acaggcccg  gggaccatg  cttagggag  3180
tgggaccca  ccaccccca  ccaggaacc  tgacgtcca  ggaaccaaa  ccagacgca  3240
aacaataaa  taaattccg  actccccac  c  3271



<210> 1988
<211> 647
<212> PRT
<213> Homo sapiens
<308> P53667
<400> 1988

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Asp Cys Ser Ala Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu Gln Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Thr Cys Gly Thr Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly His Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ser His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro 
             260                265                270
Leu Ser Ser Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Arg Ser Pro Gly 
     290                295                300
Ala Gly Ser Leu Gly Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Lys Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Val Asp Glu Lys Thr Gln Pro Glu Gly Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Tyr Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu His Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Asp Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Gly Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 1989
<211> 3258
<212> DNA
<213> Rattus norvegicus
<308> D31873
<400> 1989

gcagcggca  cgcggagcc  gtgttcttc  agcctggtg  gggagtgca  cggagcatc  60
tcgccgaag  cggagcgga  cgctcggct  cggccccgc  ctccccgcc  cccgccttc  120
cgggccggc  gcgggcgag  tcgcgggcc  ggccccagc  ctccagtgc  ccgccggtt  180
ccggcggtc  ccgcccccc  ccgagtgca  gaggttgac  ctactttgt  gcacctgga  240
ggaagaacg  atgggagag  aaggaagcg  gttgcctgt  tgtgcgagc  gtagccaga  300
tatctatga  ggccagtac  tccaggccc  gaatgctga  tggcatgcg  attgcttca  360
gtgctgcga  tgtagcacc  ccctttcac  ccagtacta  gagaaggat  gacagctct  420
ctgcaagaa  gactactgg  cccgctatg  cgagtcttg  cacgggtgc  ccgaacaca  480
caccaaagg  ctggtcatg  tgggcgggg  gctgaagta  caccccgag  gcttcatct  540
ccttgcctg  ggaaacttc  tcggtgatg  ggacaccta  acactggtg  agcactcca  600
gctgtactg  gggcagtgc  actaccaga  tgtggtaac  ccagtcatc  aacagatcc  660
ccctgactc  cccggctcc  acctgcccc  cacagtcac  ctcgtgtct  tcccagcct  720
tgctcatgg  aaacgaggc  tgtctgtct  catcgaccc  cctcacggc  caccaggat  780
tggcacgga  cattcgcac  cggtccgag  ccaaggagt  gacccgggc  gcatgagcc  840
ggatgtgaa  aattccatc  acatcggag  caggatctt  gaaatcaac  gcacgccca  900
ccggaatgt  ccgctggac  agatcgact  gctgatcca  gagaccagc  gcctgctcc  960
gctgaccct  gagcacgac  cccatgact  actgggcca  gggccagtg  cggatccca  1020
ccccctggc  tccccggta  acactccca  cggacaggc  ggcagctct  cccggcaga  1080
acctgtctt  aggagctgc  gtattgaca  gtccccggg  gccggctca  tagtctcac  1140
agcctccca  cgcaaggac  tgggtcgct  cgaatccct  cgagtggtt  gtcgaccac  1200
ccgcatctt  cggccgtct  acctcatcc  tggggaggt  ttgggcaag  gctgtttcg  1260
ccaggccat  aaggtgaca  atcgagaaa  gggcgaggt  atggtgatg  aggaactca  1320
ccggtttga  gaggagacc  agaggacat  cctcaagga  gtgaaggtc  tgcgatgcc  1380
ggagcaccc  aacgtgctc  agttcatcg  cgtgctgta  aaggacaag  ggctgaact  1440
catcaccga  tacatcaag  gcggcaccc  gcggggcat  atcaagagc  tggacagcc  1500
gtacccgtg  agtcagagg  tcagctttg  caaggacat  gcatcaggg  tggcctacc  1560
ccattcgat  aacatcatc  accgagacc  caactccca  aactgtctg  tccgtgaga  1620
caggaacgt  gtggtggct  actttgggc  ggctcgact  atgatcgat  agaagggtc  1680
gtctgaaga  ttgcgtagc  ttaagaagc  ggaccgcaa  aaacggtac  cagtggtgg  1740
taaccccta  tggatggcg  cagagatga  caatggtcg  agttacgat  aaaaggtgg  1800
cgtgttttc  tttggaatt  tcctttgtg  gattatcgg  cgtgtgaat  cagaccctg  1860
ctatctgcc  cgcactatg  actttggcc  caatgtaag  ggtttcctg  accgctact  1920
tccaccaaa  tgtccccca  gtttcttcc  catcactgt  cgctgctgt  acctggatc  1980
tgagaagag  ccctctttt  taaagctgg  acaatggct  gaaacactt  gcatgcact  2040
ggctggtca  ctgccactg  gcccacaac  ggaacaact  gagcggggc  tctgggaga  2100
ctaccggcg  ggcgagagc  cgctacccg  ccaccccga  gtccctgac  gagcccagt  2160
ggcccacca  cttcatccc  gcctctgga  aatagaccc  caccagatt  ctcagcagg  2220
ggtggccta  gcatggagc  ctcagctgg  gcagtggtg  ccatatccg  acccccaga  2280
ctgcctttt  ccctcatgc  gggtgcccc  cagcctctc  ctgcctctg  cccccaagt  2340
acaaggctg  acacacacg  ggttggtca  atcgccctg  cttacctcc  attgtgtgg  2400
gccaccccc  cacttgtct  tgcatgagc  ggagggttg  ggaagctga  cccattcca  2460
gcaatgcct  cagctgtct  cacagcgca  ctgctggca  ctcttccca  caaggctgg  2520
ccagaaggc  gctttagaa  tgagccctg  aaggccaag  gagaggcta  gtgcccggg  2580
acccaaggg  agtccagga  cccttgggg  aaatctagg  agcatcagg  attgacagg  2640
atctaaatc  caaagcaga  agagagaga  gtccagtcc  atgtggcca  gcagtggcc  2700
tcgctcttg  ttcgtgtcc  tctcatttc  tgatcaaag  cactttagt  agaagtagg  2760
accagtcct  aggatgagc  aggagccct  aggggagag  gcggatgat  cctgggaac  2820
cagctgaca  ggagggtcc  gcccacacc  cagaggcta  gcagaggga  tgaggtagc  2880
atccaccag  accccagcc  tcccggttc  tctcagcac  cttcctggg  ctctccccg  2940
ggctggagc  gccccaccc  ctccctggg  gcatctgcc  tctgagttc  ttctgtgtg  3000
tctattttt  aagaagagt  tgttttgtt  ttttgtttt  ggtgggtgg  ggtgggagg  3060
ccatctctt  actctgctt  agttgaaca  ctagggacg  attaaaact  tgaagcttt  3120
tcagtgcac  ttgaacatg  aagagaatc  gaacccccg  gggaccagg  ctgaaagag  3180
caaggcctg  ttgcctcgg  ccagtgacc  tgataggaa  gaacccaaa  tcaataaaa  3240
caattctgt  ctcccccc  3258



<210> 1990
<211> 647
<212> PRT
<213> Rattus norvegicus
<308> P53669
<400> 1990

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Ser Gln Ser Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Glu Cys Ser Thr Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu His Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Gly Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Ala Cys Gly Asn Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly Gln Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ala His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Ile Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Ser Leu Gly His Gly Pro Val Ser Asp Pro Ser Pro 
             260                265                270
Leu Ala Ser Pro Val His Thr Pro Ser Gly Gln Ala Gly Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Thr Ser Pro Gly 
     290                295                300
Ala Gly Ser Leu Val Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Arg Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Ile Asp Glu Lys Gly Gln Ser Glu Asp Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu Gln Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Glu Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Ser Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 1991
<211> 3271
<212> DNA
<213> Homo sapiens
<308> NM_016735
<400> 1991

gcgccgagc  ggtttcccc  ccggtgtcc  agaggcgcc  ccggcccgg  ccggcccgg  60
ccgcgccct  cgcccccgc  tccccgggc  ggcggcggt  ggcgagctc  cgggcccgg  120
cgcccccag  cccagcccc  ccgggcccc  ccccccgtc  agtgcatga  gttgacgct  180
ctttgttgc  cctggaggg  agaacgtat  ggagaggaa  gaagcgagt  gcccgtgtg  240
gcaagctgc  gccagagga  ctatgatgg  cagtacctc  aggccctga  cgcggactg  300
cacgcagac  gcttcaggt  ttgtgactg  agtgcctcc  tgtcgcacc  gtactatga  360
aaggatggg  agctcttct  caagaagga  tactgggcc  gctatggcg  gtcctgcca  420
gggtgctct  agcaaatca  caagggact  gttatggtg  ctggggagc  gaagtacca  480
cccgagtgt  tcatctgcc  cacgtgtgg  acctttatc  gtgacgggg  cacctacac  540
ctggtggag  actccaagc  gtactgcgg  cactgctac  accagactg  ggtgacccc  600
gtcatcgag  agatcctgc  tgactcccc  ggctcccac  tgccccaca  cgtcaccct  660
gtgtccatc  cagcctcat  tcatggcaa  cgtggactt  cagtctcca  tgacccccc  720
cacggccca  cgggctgtg  caccgagca  tcacacacc  tccgcgtcc  gggagtgga  780
ccgggctgc  tgagcccag  tgtgaagaa  tccatccac  tcggagacc  gatcttgga  840
atcaatggc  cgcccatcc  aaatgtgcc  ctggacgag  ttgacctgc  gattcagga  900
accagccgc  tgctccagc  gaccctcga  catgaccct  acgatacac  gggccacgg  960
ctggggcct  agaccagcc  cctgagctc  ccggcttat  ctcccagcg  ggaggcggg  1020
agctctgcc  ggcagaaac  tgtcttcgc  aggacctgg  tcgctctga  tccctccgc  1080
tagtctgcc  gccacaccg  atcttccgg  cgtcggacc  catccacgg  gaggtgctg  1140
gcaagggct  cttcggcca  gctatcaag  tgacacacc  tgagacagg  gaggtgatg  1200
tgatgaagg  gctgatccg  ttcgacgag  agacccaga  gacgttcct  aaggaggtg  1260
aggtcatgc  atgcctgga  caccccaac  tgctcaagt  catcggggt  ctctacaag  1320
acaagaggc  caacttcat  actgagtac  tcaagggcg  cacgctccg  ggcatcatc  1380
agagcatgg  cagccagta  ccatggagc  agagagtga  ctttgccaa  gacatcgca  1440
cagggatgg  ctacctcca  tccatgaac  tcatccacc  agacctcaa  tcccacaac  1500
gcctggtcc  cgagaacaa  aatgtggtg  tggctgact  cgggctggc  cgtctcatg  1560
tggacgaga  gactcagcc  gagggcctg  ggagcctca  gaagccaga  cgcaagaag  1620
gctacaccg  ggtgggcaa  ccctactgg  tggcacctg  gatgatcaa  ggccgcagc  1680
atgatgaga  ggtggatgt  ttctccttt  ggatcgtcc  gtgcgagat  atcgggcgg  1740
tgaacgcag  ccctgacta  ctgccccgc  ccatggact  tggcctcaa  gtgcgagga  1800
tcctggacc  ctactgccc  ccaaactgc  ccccgagct  cttccccat  accgtgcgc  1860
gttgcgatc  ggaccccga  aagaggcca  cctttgtga  gctggaaca  tggctggag  1920
ccctccgca  gcacctggc  ggccacctg  cactgggcc  acagctgga  cagctggac  1980
gaggtttct  ggagaccta  cggcgcggc  agagcggac  gcctgccca  cctgaggtc  2040
ccgactgag  cagggccac  cagctgccc  tgtccccac  tctggagaa  ccaccccca  2100
cagattcct  cgcgggagg  ggccctcag  tgggacagt  gggacccag  cttctcctc  2160
gagccaggc  ctgacttgc  ttctcccac  ccgtggacc  cttcccctg  cttctctct  2220
ccgtggccc  gagccggcc  agctgcaca  acacaccat  ctctcgccc  gctgtaacc  2280
ctgtcttgg  agggctgtc  cctcttgct  ctccttgca  gagctggag  gcctgtgtg  2340
gttacgccc  tttccacac  ccgctgccc  agcaaccct  ttcacgctc  acctgtctg  2400
tccatagct  cctggaggc  gggccagga  gcagcctcc  aaccatgcc  catataacg  2460
ttgggtgcg  gggagggcg  acatcaggg  agaggccaa  ttccaggtg  ctgtgttcc  2520
aggaaccaa  tggggagtc  ggggcccgt  ttcccccca  ggggtgtct  ggtagcaac  2580
ggtatcgag  actctccaa  cccccaaag  agagagagg  ctgatccca  ggggcggag  2640
tccccagtg  ctgagcaaa  agccccttc  ctcgctttg  gtctttttt  tgtttcttt  2700
ttaaagcca  tttagtgag  agcaggtac  aagcctcag  gtgaagggg  tcccttgag  2760
gagcgtgga  ctgcggtgc  ctggccggc  atggggagg  gccggctcc  gcagtgaga  2820
gataggcac  gtggaccgg  caggtgtcc  ccagcagct  agcccctgc  gtcatctca  2880
agccccttc  cgggcctct  ccccaaggc  ccctgcccc  cctcatgcc  ctctgtcct  2940
tgcgttttt  ctgtgtaat  tatttttta  gaagagttt  tattatttt  tcatacggc  3000
gcagcagca  ctgccaggg  cttgggatt  tatttttgt  gcgggcggg  gtgggaggg  3060
cattttgtc  ctttgcctc  gttgagcat  taggaagta  taaaactgt  aagctttct  3120
agtgcactt  gaacctgga  aacaatccc  acaggcccg  gggaccatg  cttagggag  3180
tgggaccca  ccaccccca  ccaggaacc  tgacgtcca  ggaaccaaa  ccagacgca  3240
aacaataaa  taaattccg  actccccac  c  3271



<210> 1992
<211> 647
<212> PRT
<213> Homo sapiens
<308> P53667
<400> 1992

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Asp Cys Ser Ala Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu Gln Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Thr Cys Gly Thr Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly His Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ser His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro 
             260                265                270
Leu Ser Ser Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Arg Ser Pro Gly 
     290                295                300
Ala Gly Ser Leu Gly Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Lys Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Val Asp Glu Lys Thr Gln Pro Glu Gly Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Tyr Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu His Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Asp Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Gly Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 1993
<211> 3455
<212> DNA
<213> Rattus norvegicus
<308> D31874
<400> 1993

cgggcgcgg  cctgaggtg  tgctgccgg  tggtccttc  tgtgttgtc  gcgccctgg  60
ccatggcgg  gctggcggg  gaagaggcc  ggaggtgtc  gggctgtgg  aactatgtt  120
ccctgagcc  gaggctgta  aggacagcc  acgaggcct  gcatagctc  tgcttccgg  180
gttccgagt  ccaggagtc  ctcaccaac  ggtactatg  gaaggacgg  aagctctac  240
gccacaagg  ctactgggc  aagtttgga  aattctgcc  cgggtgctc  ctgctgatg  300
cagggccag  catggtggc  ggggagttt  agtaccacc  agagtgctt  gcctgcatg  360
gttgcaagg  gatcatcga  gatggggat  cgtacgccc  ggtgcagca  gctacactc  420
actgcggga  gtgccacaa  gaggtggtg  tggcaccca  gtttgaaag  ctgtctacg  480
agtctgtcc  ggaccagct  ccctactct  tcacgctca  ctccatgcc  gccaccacc  540
agtgcagac  tggcttctc  gtgtctgtg  aaagcgcct  ctctaacta  gccaccacc  600
tgcaagtga  agaggtcaa  cggatgcac  tcagcccca  caaccgaaa  gccatccac  660
ccggggacc  catcttgga  atcaatggg  cccctgtcc  cactctccg  gtagaagag  720
tggaggatg  gattaacca  acgagccag  cacttcaac  gctgattga  catgaccct  780
tcccccagc  cctggacca  ttacggcta  acacccggc  ttctcccca  atgcagagt  840
gtggacata  tctcatgct  agcaccttg  acgccaagg  aaatcagga  ggaacactg  900
ggagacgtt  tctgaggcg  agtaacagc  tctccaagt  tcctggccc  agctccccc  960
aggagccgc  gctcctgag  cgagacatc  gtcgctcag  gtcccttcg  tgctccagc  1020
gctactcac  gcagatctt  cggccctgt  acctgatcc  cggggaggt  ctggggaag  1080
gcttcttcg  acaggccat  aaggtgact  acaaagcca  aggcaaagt  atggtcatg  1140
aggagttaa  tcgctgtga  gaggaaacc  agaagactt  cctgactga  gtgaaagtg  1200
tgcgaagcc  ggaccaccc  aacgtgctt  agttcatcg  ggtcctgta  aaggacaag  1260
agctgaatc  gctgacaga  tacattgag  ggggcaccc  gaaggactt  ctgcgcaat  1320
tggacccgt  tccctggca  cagaaggtc  ggtttgcca  aggcatcgc  tccggaatg  1380
cttatttac  ctccatgtg  atcatccac  gagatctga  ctcgcacaa  tgtctcatc  1440
aattggaca  gacggtggt  gtagcagac  tcgggctgt  acgtctcat  gtggaagag  1500
ggaaaaggc  tccagtaga  aaggccgcc  ccaagaaac  caccttacg  aagagtgat  1560
gcaagaagc  ctacactgt  gtgggaaac  cctactgga  ggcccctga  atgctgaat  1620
gcaagagct  cgatgagac  gtggatgtc  tctcttttg  gattgttct  tgtgagatc  1680
ttgggcagg  atatgctga  cccgactgc  ttccccgca  actggactt  ggcctcaac  1740
taaagcttt  ctgggagaa  tttgtccca  cagactgtc  cccagcctt  ttccccctg  1800
ctgctatct  ctgcaaact  gagcctgag  gcagaccgg  attctcaaa  ctggaggac  1860
cattcgagg  gctctccct  ttcttggga  agttggcca  cccactgcc  gcagagctg  1920
aagagctgg  ccacactgt  agcatggag  atggcctaa  ccgggactc  ccaccctag  1980
cctggtcca  ccccctgca  ggggacatt  cacagccag  attgccccc  ctgcgccct  2040
tcctcgctg  gagcgagca  gcgggactg  ctaggcttc  tgtggattg  cggcttgct  2100
agaagcaga  caagccatc  ctacctccc  aggaggcac  tgggtgcag  gaagcaatt  2160
tccacaggt  tgggcctag  ttctgtctg  aaatccaac  ctcacctga  agctgtgaa  2220
aggataaaa  cctggattc  agaccaaga  tctgttact  gggaccgcc  gggacctct  2280
gactgagat  ccgggagcc  gtagcttta  actaaccta  acggcctgg  cccgccggg  2340
cggatgagt  gactggcct  agggcctct  gttcagcaa  gtgcaggac  tgaagcgat  2400
gtatgagtt  cagaaacgg  gccgtcaaa  cgtgtgaaa  gacagagcg  tttctcctt  2460
catcctagc  atgcccttt  gagcaggtt  tgaagagtc  tagtagtgg  aaaacctac  2520
ggatccaaa  aaaaaggac  ggtttctgc  cagcagccc  gggaccaca  cagtgtgtg  2580
ggaatttcc  cttcagcac  ctgtctcaa  aagcagtct  aaaaacacc  aagaaggtg  2640
ggctggaaa  aaagcggcc  tgccgtcta  aagccccac  cccaggctg  tgggctcag  2700
cagaaactt  aggtgttgc  taacaatag  tgggttctg  atgccagtg  ggtttgcct  2760
agactttgg  cctaagcag  gagaagggg  tcccattaa  ttctttgca  ccttgtggc  2820
gctactgca  accctctag  atgtctggt  caggcagca  cttgggaca  gcattggtg  2880
ctgctgagt  ccaaactga  atatgaaga  agctccctg  gctggacct  gtagagtct  2940
cctctgttg  gctggtcca  cttacttcc  gagacacac  cgagggccg  gggcatggg  3000
aactctagg  gcactttcc  cccctggct  ccaggtgtc  agggactcc  tagctcacc  3060
aggttcgcc  tctcctaag  gggagctca  atcatattt  acacattgg  aatgggttt  3120
gttataaat  cgtgtgagg  tttgtgctg  tggggggat  cggggagag  ggctgctct  3180
attagcttt  atctgtggg  tgatatgtg  aatattttg  acatagaca  gatgaatta  3240
gggatggga  gtctttggc  actttactt  ctgtgtaga  tgtacttgt  tgtggagtt  3300
gcaaacgtg  cgcagaggg  atcctgaac  cccgacatc  gtgtggttc  gcgtcctgc  3360
gcgaattat  cacgcgctg  ccccagcga  tgtgggagt  gtgggcctg  actgggcca  3420
gaggcagac  aaataaatt  agcagttaa  agagc  3455



<210> 1994
<211> 638
<212> PRT
<213> Rattus norvegicus
<308> P53670
<400> 1994

Met Ala Ala Leu Ala Gly Glu Glu Ala Trp Arg Cys Arg Gly Cys Gly 
  1               5                  10                  15
Asn Tyr Val Pro Leu Ser Gln Arg Leu Tyr Arg Thr Ala Asn Glu Ala 
             20                  25                  30
Trp His Ser Ser Cys Phe Arg Cys Ser Glu Cys Gln Glu Ser Leu Thr 
         35                  40                  45
Asn Trp Tyr Tyr Glu Lys Asp Gly Lys Leu Tyr Cys His Lys Asp Tyr 
     50                  55                  60
Trp Ala Lys Phe Gly Glu Phe Cys His Gly Cys Ser Leu Leu Met Thr 
 65                  70                  75                  80
Gly Pro Ala Met Val Ala Gly Glu Phe Lys Tyr His Pro Glu Cys Phe 
                 85                  90                  95
Ala Cys Met Ser Cys Lys Val Ile Ile Glu Asp Gly Asp Ala Tyr Ala 
             100                105                110
Leu Val Gln His Ala Thr Leu Tyr Cys Gly Lys Cys His Asn Glu Val 
         115                120                125
Val Leu Ala Pro Met Phe Glu Arg Leu Ser Thr Glu Ser Val Gln Asp 
     130                135                140
Gln Leu Pro Tyr Ser Val Thr Leu Ile Ser Met Pro Ala Thr Thr Glu 
 145                150                155                160
Cys Arg Arg Gly Phe Ser Val Ser Val Glu Ser Ala Ser Ser Asn Tyr 
                 165                170                175
Ala Thr Thr Val Gln Val Lys Glu Val Asn Arg Met His Ile Ser Pro 
             180                185                190
Asn Asn Arg Asn Ala Ile His Pro Gly Asp Arg Ile Leu Glu Ile Asn 
         195                200                205
Gly Thr Pro Val Arg Thr Leu Arg Val Glu Glu Val Glu Asp Ala Ile 
     210                215                220
Asn Gln Thr Ser Gln Thr Leu Gln Leu Leu Ile Glu His Asp Pro Val 
 225                230                235                240
Pro Gln Arg Leu Asp Gln Leu Arg Leu Asp Thr Arg Leu Ser Pro His 
                 245                250                255
Met Gln Ser Ser Gly His Thr Leu Met Leu Ser Thr Leu Asp Ala Lys 
             260                265                270
Glu Asn Gln Glu Gly Thr Leu Arg Arg Arg Ser Leu Arg Arg Ser Asn 
         275                280                285
Ser Ile Ser Lys Ser Pro Gly Pro Ser Ser Pro Lys Glu Pro Leu Leu 
     290                295                300
Leu Ser Arg Asp Ile Ser Arg Ser Glu Ser Leu Arg Cys Ser Ser Ser 
 305                310                315                320
Tyr Ser Gln Gln Ile Phe Arg Pro Cys Asp Leu Ile His Gly Glu Val 
                 325                330                335
Leu Gly Lys Gly Phe Phe Gly Gln Ala Ile Lys Val Thr His Lys Ala 
             340                345                350
Thr Gly Lys Val Met Val Met Lys Glu Leu Ile Arg Cys Asp Glu Glu 
         355                360                365
Thr Gln Lys Thr Phe Leu Thr Glu Val Lys Val Met Arg Ser Leu Asp 
     370                375                380
His Pro Asn Val Leu Lys Phe Ile Gly Val Leu Tyr Lys Asp Lys Lys 
 385                390                395                400
Leu Asn Leu Leu Thr Glu Tyr Ile Glu Gly Gly Thr Leu Lys Asp Phe 
                 405                410                415
Leu Arg Asn Val Asp Pro Phe Pro Trp Gln Gln Lys Val Arg Phe Ala 
             420                425                430
Lys Gly Ile Ala Ser Gly Met Ala Tyr Leu His Ser Met Cys Ile Ile 
         435                440                445
His Arg Asp Leu Asn Ser His Asn Cys Leu Ile Lys Leu Asp Lys Thr 
     450                455                460
Val Val Val Ala Asp Phe Gly Leu Ser Arg Leu Ile Val Glu Glu Arg 
 465                470                475                480
Lys Arg Pro Pro Val Glu Lys Ala Ala Thr Lys Lys Arg Thr Leu Arg 
                 485                490                495
Lys Ser Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn Pro Tyr Trp 
             500                505                510
Met Ala Pro Glu Met Leu Asn Gly Lys Ser Tyr Asp Glu Thr Val Asp 
         515                520                525
Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly Gln Val Tyr 
     530                535                540
Ala Asp Pro Asp Cys Leu Pro Arg Thr Leu Asp Phe Gly Leu Asn Val 
 545                550                555                560
Lys Leu Phe Trp Glu Lys Phe Val Pro Thr Asp Cys Pro Pro Ala Phe 
                 565                570                575
Phe Pro Leu Ala Ala Ile Cys Cys Lys Leu Glu Pro Glu Ser Arg Pro 
             580                585                590
Ala Phe Ser Lys Leu Glu Asp Ser Phe Glu Ala Leu Ser Leu Phe Leu 
         595                600                605
Gly Glu Leu Ala Ile Pro Leu Pro Ala Glu Leu Glu Glu Leu Asp His 
     610                615                620
Thr Val Ser Met Glu Tyr Gly Leu Thr Arg Asp Ser Pro Pro 
 625                630                635



<210> 1995
<211> 2805
<212> DNA
<213> Homo sapiens
<308> BC013051
<400> 1995

gggaggagc  atcccagcc  tgagcccct  tgggaatct  ctgggggcc  agtggcctg  60
agtcctcag  ctcccgcag  tgctccgga  ggagaggtg  gctcagggc  gcctgcctg  120
agccagagg  gccgggagc  ccgggcctg  catggtggc  atctacagc  ggcctgagg  180
agtcacaga  ggatttgca  ctgagcctg  ctatctggt  tgggaagaa  atggggagt  240
acttgtcag  cccggctta  ttcacctcc  gagacctgt  tcggtgttc  gaatgccag  300
attccctca  caactggta  tatgagaag  atgggaagc  ctactgccc  aaggactac  360
gggggaagt  tggggagtt  tgtcatggg  gctccctgc  gatgacagg  ccttttatg  420
tggctgggg  gttcaagta  cacccagag  gctttgcct  tatgagctg  aaggtgatc  480
ttgaggatg  ggatgcata  gcactggtg  agcatgcca  cctctactg  gggaagtgc  540
acaatgagg  ggtgctggc  cccatgttt  agagactct  cacagagtc  gttcaggag  600
agctgccct  ctctgtcac  ctcatctcc  tgccggcca  cactgaagg  aggcggggc  660
tctccgtgt  cgtggagag  gcctgctcc  actacgcca  cactgtgca  gtgaaagag  720
tcaaccgga  gcacatcag  cccaacaat  gaaacgcca  ccaccctgg  gaccgcatc  780
tggagatca  tgggacccc  gtccgcaca  ttcgagtgg  ggaggtgga  gatgcaatt  840
gccagacga  ccagacact  cagctgttg  ttgaacatg  ccccgtctc  caacgcctg  900
accagctgc  gctggaggc  cggctcgct  ctcacatgc  gaatgccgg  cacccccac  960
ccctcagca  cctggacac  aaggagaat  tggagggga  actgaggag  cgttcccta  1020
ggcgcagta  cagtatctc  aagtcccct  gccccagct  cccaaagga  cccctgctg  1080
tcagccgtg  catcagccg  tcagaatcc  ttcgttgtt  cagcagcta  tcacagcag  1140
tcttccggc  ctgtgacct  atccatggg  aggtcctgg  gaagggctt  tttgggcag  1200
ctatcaagg  gacacacaa  gccacgggc  aagtgatgg  catgaaaga  ttaattcga  1260
gtgatgagg  gacccagaa  acttttctg  ctgaggtga  agtgatgcg  agcctggac  1320
accccaatg  gctcaagtt  attggtgtg  tgtacaagg  taagaagct  aacctcctg  1380
cagagtaca  tgagggggg  acactgaag  actttctgc  cagtatgga  ccgttcccc  1440
ggcagcaga  ggtcaggtt  gccaaagga  tcgcctccg  aatggccta  ttgcactct  1500
tgtgcatca  ccaccggga  ctgaactcg  acaactgcc  catcaagtt  gacaagact  1560
tggtggtgg  agactttgg  ctgtcacgg  tcatagtgg  agagaggaa  agggccccc  1620
tggagaagg  caccaccaa  aaacgcacc  tgcgcaaga  cgaccgcaa  aagcgctac  1680
cggtggtgg  aaaccccta  tggatggcc  ctgagatgc  gaacggaaa  agctatgat  1740
agacggtgg  tatcttctc  tttgggatc  ttctctgtg  gatcattgg  caggtgtat  1800
cagatcctg  ctgccttcc  cgaacactg  actttggcc  caacgtgaa  cttttctgg  1860
agaagtttg  tcccacaga  tgtcccccg  ccttcttcc  gctggccgc  atctgctgc  1920
gactggagc  tgagagcag  gcccccccc  gggccgcag  agagggccc  ggctgcgcg  1980
atgatgagg  cccagtgag  cgccaaggg  aggtcacca  caagtatga  cccaaggag  2040
tacggaagc  cctcaacct  gaggagtgg  tcctggagc  gctcacgcg  ctctacgac  2100
gccaggaag  ggagatctc  gaactagag  ttgacgtgg  tgagctcct  gacatggag  2160
gtgacgatg  ctgggcttc  agggtcaag  agctgctgg  tgactgtta  aaacccaca  2220
aggccttca  ctctggcct  ctggacaag  tccgggcca  gcagaagct  agcacaccc  2280
agaagaagt  agggtcccc  acccaggcg  acggtggct  ccataggac  atcgctacc  2340
cccgacctc  tagcaacag  aataccggg  gaccctgcg  ccaggcctg  ttccatgag  2400
agggctcct  gtgcccctg  cccaggggt  tcttcccct  ccccctcag  tttccactt  2460
tggattttt  tattgttat  aaactgatg  gactttgtg  ttttatatt  actctgcgg  2520
acgggccct  taataaagc  aggtagggt  cgcctttgg  gcagctcaa  aaaaaaaaa  2580
aaaatgatt  ccagcggtc  acattagag  tgaaatttt  tggtgggag  atctatacc  2640
tgttccttt  taggccaag  accgcagtc  ttcagtaac  ccagtgtaa  agcttgagg  2700
gaaattgtg  agctacaca  tatttgttt  ctaatacct  ttgtcattc  aaatatctt  2760
aatttatta  aaaatatat  tatacagta  aaaaaaaaa  aaaaa  2805



<210> 1996
<211> 638
<212> PRT
<213> Homo sapiens
<308> P53671
<400> 1996

Met Ser Ala Leu Ala Gly Glu Asp Val Trp Arg Cys Pro Gly Cys Gly 
  1               5                  10                  15
Asp His Ile Ala Pro Ser Gln Ile Trp Tyr Arg Thr Val Asn Glu Thr 
             20                  25                  30
Trp His Gly Ser Cys Phe Arg Cys Ser Glu Cys Gln Asp Ser Leu Thr 
         35                  40                  45
Asn Trp Tyr Tyr Glu Lys Asp Gly Lys Leu Tyr Cys Pro Lys Asp Tyr 
     50                  55                  60
Trp Gly Lys Phe Gly Glu Phe Cys His Gly Cys Ser Leu Leu Met Thr 
 65                  70                  75                  80
Gly Pro Phe Met Val Ala Gly Glu Phe Lys Tyr His Pro Glu Cys Phe 
                 85                  90                  95
Ala Cys Met Ser Cys Lys Val Ile Ile Glu Asp Gly Asp Ala Tyr Ala 
             100                105                110
Leu Val Gln His Ala Thr Leu Tyr Cys Gly Lys Cys His Asn Glu Val 
         115                120                125
Val Leu Ala Pro Met Phe Glu Arg Leu Ser Thr Glu Ser Val Gln Glu 
     130                135                140
Gln Leu Pro Tyr Ser Val Thr Leu Ile Ser Met Pro Ala Thr Thr Glu 
 145                150                155                160
Gly Arg Arg Gly Phe Ser Val Ser Val Glu Ser Ala Cys Ser Asn Tyr 
                 165                170                175
Ala Thr Thr Val Gln Val Lys Glu Val Asn Arg Met His Ile Ser Pro 
             180                185                190
Asn Asn Arg Asn Ala Ile His Pro Gly Asp Arg Ile Leu Glu Ile Asn 
         195                200                205
Gly Thr Pro Val Arg Thr Leu Arg Val Glu Glu Val Glu Asp Ala Ile 
     210                215                220
Ser Gln Thr Ser Gln Thr Leu Gln Leu Leu Ile Glu His Asp Pro Val 
 225                230                235                240
Ser Gln Arg Leu Asp Gln Leu Arg Leu Glu Ala Arg Leu Ala Pro His 
                 245                250                255
Met Gln Asn Ala Gly His Pro His Ala Leu Ser Thr Leu Asp Thr Lys 
             260                265                270
Glu Asn Leu Glu Gly Thr Leu Arg Arg Arg Ser Leu Arg Arg Ser Asn 
         275                280                285
Ser Ile Ser Lys Ser Pro Gly Pro Ser Ser Pro Lys Glu Pro Leu Leu 
     290                295                300
Phe Ser Arg Asp Ile Ser Arg Ser Glu Ser Leu Arg Cys Ser Ser Ser 
 305                310                315                320
Tyr Ser Gln Gln Ile Phe Arg Pro Cys Asp Leu Ile His Gly Glu Val 
                 325                330                335
Leu Gly Lys Gly Phe Phe Gly Gln Ala Ile Lys Val Thr His Lys Ala 
             340                345                350
Thr Gly Lys Val Met Val Met Lys Glu Leu Ile Arg Cys Asp Glu Glu 
         355                360                365
Thr Gln Lys Thr Phe Leu Thr Glu Val Lys Val Met Arg Ser Leu Asp 
     370                375                380
His Pro Asn Val Leu Lys Phe Ile Gly Val Leu Tyr Lys Asp Lys Lys 
 385                390                395                400
Leu Asn Leu Leu Thr Glu Tyr Ile Glu Gly Gly Thr Leu Lys Asp Phe 
                 405                410                415
Leu Arg Ser Met Asp Pro Phe Pro Trp Gln Gln Lys Val Arg Phe Ala 
             420                425                430
Lys Gly Ile Ala Ser Gly Met Ala Tyr Leu His Ser Met Cys Ile Ile 
         435                440                445
His Arg Asp Leu Asn Ser His Asn Cys Leu Ile Lys Leu Asp Lys Thr 
     450                455                460
Val Val Val Ala Asp Phe Gly Leu Ser Arg Leu Ile Val Glu Glu Arg 
 465                470                475                480
Lys Arg Ala Pro Met Glu Lys Ala Thr Thr Lys Lys Arg Thr Leu Arg 
                 485                490                495
Lys Asn Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn Pro Tyr Trp 
             500                505                510
Met Ala Pro Glu Met Leu Asn Gly Lys Ser Tyr Asp Glu Thr Val Asp 
         515                520                525
Ile Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly Gln Val Tyr 
     530                535                540
Ala Asp Pro Asp Cys Leu Pro Arg Thr Leu Asp Phe Gly Leu Asn Val 
 545                550                555                560
Lys Leu Phe Trp Glu Lys Phe Val Pro Thr Asp Cys Pro Pro Ala Phe 
                 565                570                575
Phe Pro Leu Ala Ala Ile Cys Cys Arg Leu Glu Pro Glu Ser Arg Pro 
             580                585                590
Ala Phe Ser Lys Leu Glu Asp Ser Phe Glu Ala Leu Ser Leu Tyr Leu 
         595                600                605
Gly Glu Leu Gly Ile Pro Leu Pro Ala Glu Leu Glu Glu Leu Asp His 
     610                615                620
Thr Val Ser Met Gln Tyr Gly Leu Thr Arg Asp Ser Pro Pro 
 625                630                635



<210> 1997
<211> 4758
<212> DNA
<213> Rattus norvegicus
<308> D32249
<400> 1997

tggcgggtg  aggatcgag  gctgttctc  ctctggagc  gctgcacat  tcggaatca  60
ttgcagctt  ttcactgtg  aaggaaaaa  caaattaca  ccataattc  attgaactg  120
aagcataga  gctgccata  atgtcacag  atacagaaa  agaaccatc  gtaatggat  180
aagactcca  caaggctgc  tggcctaga  cagcaggag  ataccagac  attacaggc  240
ggaggtacg  aaggagaca  gcgtatgtc  gttttaagc  atgtatgac  aggcatgaa  300
ggagcttgg  tcgggctgg  gatgactat  aagttctgg  actggatga  gttgccaag  360
aaaacaccg  aggttccag  tcattggat  aagtccatc  ttctttacc  agtgaaact  420
cagttgaaa  aagtgaaac  gaaattcct  cttgtggtc  agcactgaa  caaagcacg  480
agagcaacc  atccgttgc  acagtgtgt  atagtgagg  agtcaggga  accttagac  540
gcagtacga  tcttcagaa  cacgctgag  gagagtgta  gccagcagt  tgtaatgcc  600
caagtgtcc  gaatggaat  gtgttggtt  atactgact  ttatgatcc  gacagcaag  660
atgatgaga  tgactctct  caactttgt  cccaagctg  ggaaggtgg  agacgtcag  720
aggtattag  caatgcagt  tttgagctg  aaaatggag  ggtagagag  tatgctgat  780
tgtgtccct  agttccctc  ctcagtggt  aaataaggg  ggagtctga  gagctaggt  840
cagcactct  agagaaaaa  tctgctggc  atgcggagg  tgtccatca  gatgggcag  900
aatttcaga  gtcttctga  gacggcatt  ttagaaaga  gcgacaaga  gataccgat  960
agggaagac  gacagaaaa  tcaactgaa  atgcagact  tgttccagg  catgttgaa  1020
aaaatacta  tgagagagc  aatcaccat  gaagttctc  tgaacaggt  gtgaggccc  1080
aagttagaa  agtgatcag  tcaagccag  tggaccaag  gagcggttt  aataggcac  1140
aggctaagc  aagaagtgt  cagaggtgg  gagaggctc  ggaagttga  gaatgcagt  1200
cagatgacc  tataatcaa  tgtgacgat  atgatggag  ccatgactg  atgttccta  1260
ccccatcct  ctcaagagt  acgccaagg  aagcagaac  tcaccgtgc  acagcagaa  1320
atggagcca  agcttcagg  aggcaagag  ctcgggaaa  tgccttttg  aatgcctgt  1380
gagagtatt  ccagctctt  gacaaagac  aagacagtt  agagtgcag  gatggggaa  1440
ggtctgctt  tctgcctca  cgattttct  gcacagaaa  agaccagtc  tcaagcgat  1500
aaagctggg  aactctgcc  ggaaaagat  agaatgaac  tgagctaca  agtgatagt  1560
gtggccctg  ggaagaaaa  caagaattg  ctcttcagg  gggagaaca  acgtccttg  1620
aggaggggg  gattccctg  ttacagtac  atgaggtca  tgagagcag  agcgatgaa  1680
ggaacgagc  tgccaatga  tttgcacaa  cagaagctt  catgttgga  gggaacaac  1740
acctggagg  cgactcgag  gtgagtgaa  acctggatg  ggactggag  ctatttgat  1800
gttttgcgg  tggacttgg  gttgctgaa  ctatttcct  cgtggatcc  cagttcctc  1860
cctacatgg  actagaaga  cgcttagcc  aggctatgg  gactgcact  gcacactta  1920
agtctcttg  tgtagacgt  gaggtggct  acccacctg  cagtaagga  agcatcgac  1980
gacttccag  aacccttgt  ctagaagat  acaccgcta  tggtcagga  cagtgctgt  2040
ccatctgct  cagtgagta  attaaggat  acatcgcaa  agagctgcc  tgccatcac  2100
tctttcata  gccttgtgt  tccatttgg  tacagaagt  cggaacgtg  cctgtgtgc  2160
gccgccact  cccacctgc  gtgattgac  catctgcag  tgcttcctc  gaaccagac  2220
ttgatgcct  gcctgcaaa  gacaatgct  aggaagccc  gtaagccgt  acggggaaa  2280
gagatcgaa  ttctatcac  gtaaatctg  aaattcctt  taaatctga  gtgcaaata  2340
ttatatata  atatattta  aatgctcta  atagtatat  ccgtagttt  gaaagagaa  2400
attaacctt  ctaaactga  tttaggttt  cagaagata  taaacattt  caagctgaa  2460
gttgaagca  tgcatccat  ttctttagt  gaacatggt  tccattgta  cgtcagtag  2520
catctctgt  gcatacgtt  ctgttttgt  tgaagtgct  ccactaaga  atcagaatt  2580
agctctcct  tccacatca  atgtgaaag  agagcttaa  tctgatctc  gtggcatac  2640
tttctgttt  gtctgaagt  ctgccacta  gagatcaga  ttaagctct  ctttccaca  2700
cagatgtga  aactgtgat  acaacagta  tacagtttg  tttcattga  aataaactg  2760
attctaaag  atgcttttt  actggtccc  ttgcttttg  tacttcgag  cctcttggt  2820
tatataaca  tgaggttaa  attaaagct  ttcagaatg  caggcaaag  ctagagttt  2880
gacccgaac  cacacacaa  ataaaaaaa  aaaaaataa  ttacatctt  gatgtaaac  2940
tcctgaaac  gtcatgtaa  aaactattc  gtgaacgtt  gatgtttaa  ggctagtaa  3000
gcatgtgaa  tatctgatg  gcttcatgc  cggcacagt  tcatgagct  ggcctatga  3060
acactgtct  agccctcat  cagtctgct  ctacttgtt  aacactgaa  gtccagacc  3120
gtcttggca  ctgattaag  aattggatg  agttagcta  ggtagtttg  gttctactt  3180
aggagatct  aagatttgc  catggccat  tctgttaca  catcacccc  gattagaaa  3240
gcacagctt  taggtggtc  cacgagtag  caagtctgt  cagacgctg  tgtgatagg  3300
agcttacag  tgagccctg  catcagcac  gggacaacg  ctcagcagg  ccagcactg  3360
agcccatcc  cgtgcacat  tacctgccc  gctcatcca  ttcgggaat  tttctatag  3420
ttcccaaat  agcttcatc  gatttgtgt  atatatctg  gtatttata  tctttcttt  3480
ttctccagt  ttaaaaata  atgaatttt  actgttggc  catttgagg  ttaaatata  3540
gaaacctaa  acttgcatt  tgatttttg  atatattgt  aatgtggct  gtatttaca  3600
cgaatcctg  gtgtccttt  atgggtaaa  caaaagtga  cattgcatg  aagtaatgt  3660
gtgaatttg  aatttaggg  ttttctggg  cttctgtga  tgtggatgc  taaattcag  3720
ccttaatgt  gctctagct  gcatgtttc  ttctaatgt  catagtcag  ctgtatcca  3780
taatctctg  ttgtcttct  ctccgtggt  ttcacaccg  atccactga  ggtcagtta  3840
tgtcagagg  cacccaggt  agcatcagt  cccatgtgt  ccgtgcgga  tgtgagccg  3900
gtggttgct  ggttggttt  cttttatgt  ctttgatta  ctgtggcac  tactgagta  3960
acttacgtt  ctgcagact  ctgtgtaac  agccacgtt  tgtgtttag  cagtattac  4020
cacgggacc  tgttttatt  ttctagata  cagctgtcc  aaagaaaat  tttcttctt  4080
gcctattaa  atttagcta  tatctgcca  ttgttaagg  gtttgattc  aaactcaac  4140
agagttgaa  gtaagaaag  tgctgtact  ttgctgtcc  tctgttacg  cctccgttg  4200
tggctcctg  ctacgtacc  acggctgct  aaggagact  gttttaatt  gttttaaaa  4260
ggaaaatga  gttttagga  tttgatggt  gggaagctg  caagttcag  ccccagtct  4320
tcatttgct  ttagcttgg  tccttttga  aagttaaga  tatatgaag  taaattaga  4380
aaagtaaaa  tattgataa  atgtcattt  tcttatgtc  attttatgt  gttatttgg  4440
ctattaatt  taatttttt  aacattttc  tatttcttg  aatatgaat  ccgatattt  4500
aagtttgac  cacttgggt  tcttttgtg  ttcttagtt  ttatctcta  gcctaacta  4560
cttttaaga  tatttgtga  atggattta  ataagctgt  aaatatata  gagctgtta  4620
aatggaatg  aaggttttc  aaagaccag  tctaactgt  atgattggt  tattgttct  4680
caatcccag  ccggcattt  ccgtgtaaa  cataaacaa  aaacaggat  tactcagtg  4740
tcatttcta  aaaaaaaa  4758



<210> 1998
<211> 707
<212> PRT
<213> Rattus norvegicus
<308> BAA06979
<400> 1998

Met Ser Gln Tyr Thr Glu Lys Glu Pro Ser Val Met Asp Gln Asp Ser 
  1               5                  10                  15
Ser Lys Ala Ala Trp Pro Arg Ala Ala Gly Gly Tyr Gln Thr Ile Thr 
             20                  25                  30
Gly Arg Arg Tyr Gly Arg Arg His Ala Tyr Val Ser Phe Lys Pro Cys 
         35                  40                  45
Met Thr Arg His Glu Arg Ser Leu Gly Arg Ala Gly Asp Asp Tyr Glu 
     50                  55                  60
Val Leu Glu Leu Asp Asp Val Ala Lys Glu Asn Thr Ala Gly Ser Ser 
 65                  70                  75                  80
Ser Leu Asp Gln Val His Pro Ser Leu Pro Ser Glu Thr Thr Val Glu 
                 85                  90                  95
Lys Ser Glu Thr Glu Ile Pro Thr Cys Gly Pro Ala Leu Asn Gln Ser 
             100                105                110
Thr Glu Ser Asn Pro Ser Val Ala Thr Val Cys His Ser Glu Glu Val 
         115                120                125
Arg Glu Thr Leu Asp Ser Ser Thr Asn Leu Gln Asn His Ala Glu Arg 
     130                135                140
Glu Cys Thr Pro Ala Val Cys Asn Ala Ser Ser Val Gln Asn Gly Ile 
 145                150                155                160
Val Leu Val His Thr Asp Ser Tyr Asp Pro Asp Ser Lys His Asp Glu 
                 165                170                175
Asn Asp Ser Leu Gln Leu Cys Ala Gln Ala Val Glu Gly Gly Arg Arg 
             180                185                190
Gln Lys Val Leu Gly Asn Ala Val Phe Glu Leu Glu Asn Gly Glu Val 
         195                200                205
Glu Arg Tyr Ala Asp Leu Cys Pro Ser Val Pro Ser Leu Ser Gly Glu 
     210                215                220
Ile Arg Glu Glu Ser Glu Glu Leu Gly Ser Ala Leu Leu Glu Lys Asn 
 225                230                235                240
Ser Ala Gly Asp Ala Glu Ala Val His Gln Asp Gly Gln Glu Phe Gln 
                 245                250                255
Arg Ser Ser Glu Asp Gly Ile Val Arg Lys Arg Arg Gln Asp Asp Thr 
             260                265                270
Asp Gln Gly Arg Gln Thr Glu Asn Ser Thr Glu Asp Ala Asp Cys Val 
         275                280                285
Pro Gly His Val Glu Gln Asn Thr Ser Glu Arg Ala Asn His His Gly 
     290                295                300
Ser Ser Pro Glu Gln Val Val Arg Pro Lys Val Arg Lys Val Ile Ser 
 305                310                315                320
Ser Ser Gln Val Asp Gln Glu Ser Gly Phe Asn Arg His Glu Ala Lys 
                 325                330                335
Gln Arg Ser Val Gln Arg Trp Arg Glu Ala Leu Glu Val Glu Glu Cys 
             340                345                350
Ser Ser Asp Asp Pro Ile Ile Lys Cys Asp Asp Tyr Asp Gly Asp His 
         355                360                365
Asp Cys Met Phe Leu Thr Pro Ser Tyr Ser Arg Val Thr Pro Arg Glu 
     370                375                380
Ala Glu Arg His Arg Ala Thr Ala Glu Asn Gly Ala Thr Ala Ser Gly 
 385                390                395                400
Arg Gln Glu Ala Arg Glu Asn Ala Phe Trp Asn Ala Cys Gly Glu Tyr 
                 405                410                415
Tyr Gln Leu Phe Asp Lys Asp Glu Asp Ser Ser Glu Cys Ser Asp Gly 
             420                425                430
Glu Trp Ser Ala Ser Leu Pro His Arg Phe Ser Gly Thr Glu Lys Asp 
         435                440                445
Gln Ser Ser Ser Asp Glu Ser Trp Glu Thr Leu Pro Gly Lys Asp Glu 
     450                455                460
Asn Glu Pro Glu Leu Gln Ser Asp Ser Ser Gly Pro Glu Glu Glu Asn 
 465                470                475                480
Gln Glu Leu Ser Leu Gln Glu Gly Glu Gln Thr Ser Leu Glu Glu Gly 
                 485                490                495
Glu Ile Pro Trp Leu Gln Tyr Asn Glu Val Asn Glu Ser Ser Ser Asp 
             500                505                510
Glu Gly Asn Glu Pro Ala Asn Glu Phe Ala Gln Pro Glu Ala Phe Met 
         515                520                525
Leu Asp Gly Asn Asn Asn Leu Glu Asp Asp Ser Ser Val Ser Glu Asp 
     530                535                540
Leu Asp Val Asp Trp Ser Leu Phe Asp Gly Phe Ala Asp Gly Leu Gly 
 545                550                555                560
Val Ala Glu Ala Ile Ser Tyr Val Asp Pro Gln Phe Leu Thr Tyr Met 
                 565                570                575
Ala Leu Glu Glu Arg Leu Ala Gln Ala Met Glu Thr Ala Leu Ala His 
             580                585                590
Leu Glu Ser Leu Ala Val Asp Val Glu Val Ala Asn Pro Pro Ala Ser 
         595                600                605
Lys Glu Ser Ile Asp Gly Leu Pro Glu Thr Leu Val Leu Glu Asp His 
     610                615                620
Thr Ala Ile Gly Gln Glu Gln Cys Cys Pro Ile Cys Cys Ser Glu Tyr 
 625                630                635                640
Ile Lys Asp Asp Ile Ala Thr Glu Leu Pro Cys His His Phe Phe His 
                 645                650                655
Lys Pro Cys Val Ser Ile Trp Leu Gln Lys Ser Gly Thr Cys Pro Val 
             660                665                670
Cys Arg Arg His Phe Pro Pro Ala Val Ile Asp Ala Ser Ala Ala Ala 
         675                680                685
Ser Ser Glu Pro Asp Leu Asp Ala Ser Pro Ala Asn Asp Asn Ala Glu 
     690                695                700
Glu Ala Pro 
 705



<210> 1999
<211> 4765
<212> DNA
<213> Homo sapiens
<308> AB007898
<400> 1999

gttctcgct  cggagccgc  gcacatttc  gaatcttct  cggcttgtc  atagtgtga  60
taaaaacta  atcacatct  taattctac  gaactggtc  tacagacgc  gccatatat  120
tcacagtac  ctgaaaagg  gccagcagc  atggaccaa  aatctggta  ggctgtctg  180
cccaaacca  caggagggt  tcagacaat  acaggcagg  gatatggaa  aagacatgc  240
tatgtcagt  ttaaaccat  tatgaccag  catgaaaga  gcttaggtc  ggctggtga  300
gactatgaa  tgttggaac  agatgatgt  ccaaaggaa  attcctcag  ttccagtcc  360
ttggatcaa  ttgattctt  tttacccag  gaacctata  ttgaaaaaa  tgaaacaga  420
attcccact  gtggttcag  attgaatca  accactgag  gcagtcaat  ctttgttgc  480
gtacatcac  gtgaggaag  cagggatac  ttaggaagc  gtacaaatc  tcataatca  540
tctgaggga  agtatattc  aggagcttg  agtgcttca  gtgtccaaa  tggaattgc  600
ttggttcat  cagactctt  tgatccaga  ggcaaacat  gagaagata  tgaccatct  660
caactttct  cagaagtcg  ggaaggtag  agataccag  aatcattag  caatacagt  720
tttgagttg  aaaacagag  ggcagaggc  tacactggt  tttcaccac  agttccctc  780
tttaactgt  aagtaagag  tgagtttga  gagttagat  ctgtaccat  agtgaaaag  840
tctgctggt  atactgagt  tgtccatca  aatagccag  aaattcaga  gtcttctca  900
gatgaaatg  ttagtacga  acaacaaaa  aatactagc  aggaaagac  gacagaaca  960
tcacctgaa  atgcagcct  tggtccagg  catatttgt  gtgaacgaa  taccaatga  1020
agggaaaag  accatggaa  ttctcctga  caggtagtg  ggccaaaag  tagaaaact  1080
ataagttca  gccaggtgg  ccaagaaac  ggttttaat  ggcatgagg  gaaacaaag  1140
agtgttcaa  gatggagag  ggctttgga  gttgaggaa  gtggctcag  tgacctctt  1200
ataaaatgt  aagaatatg  tggagagca  gactgtatg  tcttggatc  accatactc  1260
agagttatt  cacaaaggg  aacagaaaa  aaccaaatg  catcagaaa  tggagccac  1320
gcgggaagg  aagaagtgg  taacacctt  tggaatggc  gtggagatt  ttaccaact  1380
tatgacaaa  atgaagata  ttctgaatg  agtgatggg  aatggtctg  ttctttgcc  1440
catcgattt  ctggtacag  aaaagatca  tcctcaagt  atgaaagct  ggagactct  1500
ccaggaaaa  atgagaatg  acctgagct  caaagtgat  gcagtggcc  tgaagaaga  1560
aaccaagaa  tatctcttc  ggaagggga  cagacatcc  tggaagagg  agaaattcc  1620
tggttacag  acaatgaag  caatgaaag  agcagtgat  agggaaatg  acctgccaa  1680
gaatttgca  agccagctt  catgttgga  ggtaacaat  acctggagg  tgactccag  1740
gtgagtgaa  acttagatg  ggattggag  ctatttgat  gctttgcag  tggactagg  1800
gttgctgaa  ctatttcat  tgtggatcc  cagttcctt  cctacatgg  actagaaga  1860
cgcttagcc  aggctatgg  gactgctct  gcccattta  agtctcttg  agtggatgt  1920
gaggtggcc  atccaccag  tagtaagga  agcattgat  gtcttccag  gacccttgt  1980
cttgaagat  acactgcta  tggtcagga  caatgctgt  caatctgtt  cagtgagta  2040
attaaggat  atatagcaa  agagttgcc  tgtcaccat  tctttcaca  accttgtgt  2100
tcaatttgg  tacaaaagt  gggaacatg  cctgtgtgc  gccgtcatt  cccacctgc  2160
gttattgaa  catctgcag  tccttcctc  gagcctgat  ctgatgccc  accttcaaa  2220
gacagtatt  cagaagcac  ctaaacctt  acagttgaa  tgagatcag  gtatcaaag  2280
aaatctgca  attccttct  aatttcatg  gcaaataat  atatataaa  atatttaaa  2340
atgctatat  tagtatatg  catagttta  aaagaatat  aacctttct  aactaaatt  2400
aggtttgca  aaagtatta  acattttta  gctgaatgt  gagacagtg  atccatttt  2460
tttagttga  tatgtttgt  ttaattgta  agccaagct  atcagttga  tctctccag  2520
ataaataat  atctgtgtg  catacgtta  tggctttgt  tgtaatact  ccactaagt  2580
attataatt  agctgtcct  tttgcatca  atgtaaaga  tgtgttcac  accgtagta  2640
aatttggtt  cattggaaa  gaaacaaat  ctaaagtat  ctttttcac  agtcccttt  2700
attttgcta  atcataacc  cttggttca  atgctgaga  atttttcag  aagtccatt  2760
ttgtttaaa  ttagaactt  tcagaatgc  aaatgaagg  taaaatttt  gccagaaca  2820
tacaaaagt  ttaaatcgt  gacgtaact  cccctgaaa  aaagttagg  agtaaaatc  2880
ttaatgaaa  cagtggatg  gcttaacgt  aggttagta  agcatacaa  gaatctagt  2940
tgctcaggg  ttggtacaa  gagctgaat  agatggcct  atgaaactc  ttctaacct  3000
ttacccaac  tgtttctcc  tggttaaaa  tatacttga  ggcccagaa  actcatggc  3060
catttgttt  atattgctt  tagttagtt  aaggtaatt  tgcttctac  gtattttgg  3120
aggtctgaa  acttgcaca  ggtcatctt  gtaattata  aaccccaaa  taagatgca  3180
aatgtctcc  tcaggtgat  acacacagt  gacgagtat  tgcaaacat  gacataata  3240
ttcacttac  aatgtgatt  gatgttaac  ctagagaat  atgactgta  aacatttga  3300
caagtaaaa  agtaaagca  atagtgagt  tatgtccgt  taactggta  attgataat  3360
tagtttggg  acataaaag  aatatttat  tggcttccc  aatgcagag  tacatctta  3420
tcgtgtatt  ctctgagta  ttatatccc  tctcctttt  tcattctta  aaataaatg  3480
attttcact  ttggcacat  tgaggctta  atataagga  cataacact  gcattctaa  3540
ttttgcata  attgtaaat  tgtctggta  ttacagcaa  atactgtgt  tccttttat  3600
ggtaaaaca  aagtgaaca  tgcatgcat  taatgtgat  aatttgtaa  ttaggagtt  3660
tttggggct  ctgtgactt  ggaaatgct  acattcagg  cttaatgtt  cattagcta  3720
catgttttc  ctctgatgt  tatagtcac  gttgtataa  ctaatcttt  cttgttttc  3780
actctgtga  ctttccata  catatttca  taatgatca  ttagtgtca  ggagtcaaa  3840
cagattaaa  ttaatttca  gtgtatatg  tggaaattt  tggctagtg  gatttttgt  3900
tgtttcctt  taagtactg  tgatcagtt  tgacactta  tggttaaac  tacgttgct  3960
aagatttct  tataataag  cacacatta  atttagact  tattaaggg  ccttggttt  4020
cttctagat  gcagctgtc  caaagaaaa  atttcttct  tgtctgtta  gatttagct  4080
ttatctgcc  gttgttaag  ggttttggt  ccaaactca  ccagcaatg  tgagagctg  4140
acttaagat  gctgttgta  tttttgctt  ccatctgtt  ctgtccttc  ttcttggct  4200
cctactatc  ataaacagc  gctgtgaag  agaaaagtt  aataagagt  ggcttaaat  4260
ttaaaaaag  aaaagaaaa  tgaggtttt  ggattttca  ggtaacaag  tctggtata  4320
gctaaggct  gcaagttca  atactaaaa  attatttga  catatcttg  atccttttg  4380
aaaagttaa  actatatga  ggtaaatta  aaataagta  gaatattaa  aaaatagca  4440
ttatcttat  tctctattt  atgttgtga  ttaacctaa  tttattttt  taacatttt  4500
ttatttctt  taatatgaa  gctgatatt  aaaggtaga  ctatgtggt  ttctttgtg  4560
ttcttaatt  tttaactct  aagattatt  gtgatctgg  tttatgtat  tgttagata  4620
atacgaatt  ttaaaatgg  atgcaagtt  ttcaaaagc  caggtctaa  tgtaatggt  4680
ggtttattg  tctataacc  cagcccatc  ttttctgtg  aaatcataa  caataaaca  4740
aatatactc  gtggtcatt  ctaat  4765



<210> 2000
<211> 708
<212> PRT
<213> Homo sapiens
<308> XP_003693
<400> 2000

Met Ser Gln Tyr Thr Glu Lys Glu Pro Ala Ala Met Asp Gln Glu Ser 
  1               5                  10                  15
Gly Lys Ala Val Trp Pro Lys Pro Ala Gly Gly Tyr Gln Thr Ile Thr 
             20                  25                  30
Gly Arg Arg Tyr Gly Arg Arg His Ala Tyr Val Ser Phe Lys Pro Cys 
         35                  40                  45
Met Thr Arg His Glu Arg Ser Leu Gly Arg Ala Gly Asp Asp Tyr Glu 
     50                  55                  60
Val Leu Glu Leu Asp Asp Val Pro Lys Glu Asn Ser Ser Gly Ser Ser 
 65                  70                  75                  80
Pro Leu Asp Gln Val Asp Ser Ser Leu Pro Ser Glu Pro Ile Phe Glu 
                 85                  90                  95
Lys Ser Glu Thr Glu Ile Pro Thr Cys Gly Ser Ala Leu Asn Gln Thr 
             100                105                110
Thr Glu Ser Ser Gln Ser Phe Val Ala Val His His Ser Glu Glu Gly 
         115                120                125
Arg Asp Thr Leu Gly Ser Ser Thr Asn Leu His Asn His Ser Glu Gly 
     130                135                140
Glu Tyr Ile Pro Gly Ala Cys Ser Ala Ser Ser Val Gln Asn Gly Ile 
 145                150                155                160
Ala Leu Val His Thr Asp Ser Tyr Asp Pro Asp Gly Lys His Gly Glu 
                 165                170                175
Asp Asn Asp His Leu Gln Leu Ser Ala Glu Val Val Glu Gly Ser Arg 
             180                185                190
Tyr Gln Glu Ser Leu Gly Asn Thr Val Phe Glu Leu Glu Asn Arg Glu 
         195                200                205
Ala Glu Ala Tyr Thr Gly Leu Ser Pro Pro Val Pro Ser Phe Asn Cys 
     210                215                220
Glu Val Arg Asp Glu Phe Glu Glu Leu Asp Ser Val Pro Leu Val Lys 
 225                230                235                240
Ser Ser Ala Gly Asp Thr Glu Phe Val His Gln Asn Ser Gln Glu Ile 
                 245                250                255
Gln Arg Ser Ser Gln Asp Glu Met Val Ser Thr Lys Gln Gln Asn Asn 
             260                265                270
Thr Ser Gln Glu Arg Gln Thr Glu His Ser Pro Glu Asp Ala Ala Cys 
         275                280                285
Gly Pro Gly His Ile Cys Ser Glu Gln Asn Thr Asn Asp Arg Glu Lys 
     290                295                300
Asn His Gly Ser Ser Pro Glu Gln Val Val Arg Pro Lys Val Arg Lys 
 305                310                315                320
Leu Ile Ser Ser Ser Gln Val Asp Gln Glu Thr Gly Phe Asn Arg His 
                 325                330                335
Glu Ala Lys Gln Arg Ser Val Gln Arg Trp Arg Glu Ala Leu Glu Val 
             340                345                350
Glu Glu Ser Gly Ser Asp Asp Leu Leu Ile Lys Cys Glu Glu Tyr Asp 
         355                360                365
Gly Glu His Asp Cys Met Phe Leu Asp Pro Pro Tyr Ser Arg Val Ile 
     370                375                380
Thr Gln Arg Glu Thr Glu Asn Asn Gln Met Thr Ser Glu Ser Gly Ala 
 385                390                395                400
Thr Ala Gly Arg Gln Glu Val Asp Asn Thr Phe Trp Asn Gly Cys Gly 
                 405                410                415
Asp Tyr Tyr Gln Leu Tyr Asp Lys Asp Glu Asp Ser Ser Glu Cys Ser 
             420                425                430
Asp Gly Glu Trp Ser Ala Ser Leu Pro His Arg Phe Ser Gly Thr Glu 
         435                440                445
Lys Asp Gln Ser Ser Ser Asp Glu Ser Trp Glu Thr Leu Pro Gly Lys 
     450                455                460
Asp Glu Asn Glu Pro Glu Leu Gln Ser Asp Ser Ser Gly Pro Glu Glu 
 465                470                475                480
Glu Asn Gln Glu Leu Ser Leu Gln Glu Gly Glu Gln Thr Ser Leu Glu 
                 485                490                495
Glu Gly Glu Ile Pro Trp Leu Gln Tyr Asn Glu Val Asn Glu Ser Ser 
             500                505                510
Ser Asp Glu Gly Asn Glu Pro Ala Asn Glu Phe Ala Gln Pro Ala Phe 
         515                520                525
Met Leu Asp Gly Asn Asn Asn Leu Glu Asp Asp Ser Ser Val Ser Glu 
     530                535                540
Asp Leu Asp Val Asp Trp Ser Leu Phe Asp Gly Phe Ala Asp Gly Leu 
 545                550                555                560
Gly Val Ala Glu Ala Ile Ser Tyr Val Asp Pro Gln Phe Leu Thr Tyr 
                 565                570                575
Met Ala Leu Glu Glu Arg Leu Ala Gln Ala Met Glu Thr Ala Leu Ala 
             580                585                590
His Leu Glu Ser Leu Ala Val Asp Val Glu Val Ala Asn Pro Pro Ala 
         595                600                605
Ser Lys Glu Ser Ile Asp Gly Leu Pro Glu Thr Leu Val Leu Glu Asp 
     610                615                620
His Thr Ala Ile Gly Gln Glu Gln Cys Cys Pro Ile Cys Cys Ser Glu 
 625                630                635                640
Tyr Ile Lys Asp Asp Ile Ala Thr Glu Leu Pro Cys His His Phe Phe 
                 645                650                655
His Lys Pro Cys Val Ser Ile Trp Leu Gln Lys Ser Gly Thr Cys Pro 
             660                665                670
Val Cys Arg Arg His Phe Pro Pro Ala Val Ile Glu Ala Ser Ala Ala 
         675                680                685
Pro Ser Ser Glu Pro Asp Pro Asp Ala Pro Pro Ser Asn Asp Ser Ile 
     690                695                700
Thr Glu Ala Pro 
 705



<210> 2001
<211> 4758
<212> DNA
<213> Rattus norvegicus
<308> D32249
<400> 2001

tggcgggtg  aggatcgag  gctgttctc  ctctggagc  gctgcacat  tcggaatca  60
ttgcagctt  ttcactgtg  aaggaaaaa  caaattaca  ccataattc  attgaactg  120
aagcataga  gctgccata  atgtcacag  atacagaaa  agaaccatc  gtaatggat  180
aagactcca  caaggctgc  tggcctaga  cagcaggag  ataccagac  attacaggc  240
ggaggtacg  aaggagaca  gcgtatgtc  gttttaagc  atgtatgac  aggcatgaa  300
ggagcttgg  tcgggctgg  gatgactat  aagttctgg  actggatga  gttgccaag  360
aaaacaccg  aggttccag  tcattggat  aagtccatc  ttctttacc  agtgaaact  420
cagttgaaa  aagtgaaac  gaaattcct  cttgtggtc  agcactgaa  caaagcacg  480
agagcaacc  atccgttgc  acagtgtgt  atagtgagg  agtcaggga  accttagac  540
gcagtacga  tcttcagaa  cacgctgag  gagagtgta  gccagcagt  tgtaatgcc  600
caagtgtcc  gaatggaat  gtgttggtt  atactgact  ttatgatcc  gacagcaag  660
atgatgaga  tgactctct  caactttgt  cccaagctg  ggaaggtgg  agacgtcag  720
aggtattag  caatgcagt  tttgagctg  aaaatggag  ggtagagag  tatgctgat  780
tgtgtccct  agttccctc  ctcagtggt  aaataaggg  ggagtctga  gagctaggt  840
cagcactct  agagaaaaa  tctgctggc  atgcggagg  tgtccatca  gatgggcag  900
aatttcaga  gtcttctga  gacggcatt  ttagaaaga  gcgacaaga  gataccgat  960
agggaagac  gacagaaaa  tcaactgaa  atgcagact  tgttccagg  catgttgaa  1020
aaaatacta  tgagagagc  aatcaccat  gaagttctc  tgaacaggt  gtgaggccc  1080
aagttagaa  agtgatcag  tcaagccag  tggaccaag  gagcggttt  aataggcac  1140
aggctaagc  aagaagtgt  cagaggtgg  gagaggctc  ggaagttga  gaatgcagt  1200
cagatgacc  tataatcaa  tgtgacgat  atgatggag  ccatgactg  atgttccta  1260
ccccatcct  ctcaagagt  acgccaagg  aagcagaac  tcaccgtgc  acagcagaa  1320
atggagcca  agcttcagg  aggcaagag  ctcgggaaa  tgccttttg  aatgcctgt  1380
gagagtatt  ccagctctt  gacaaagac  aagacagtt  agagtgcag  gatggggaa  1440
ggtctgctt  tctgcctca  cgattttct  gcacagaaa  agaccagtc  tcaagcgat  1500
aaagctggg  aactctgcc  ggaaaagat  agaatgaac  tgagctaca  agtgatagt  1560
gtggccctg  ggaagaaaa  caagaattg  ctcttcagg  gggagaaca  acgtccttg  1620
aggaggggg  gattccctg  ttacagtac  atgaggtca  tgagagcag  agcgatgaa  1680
ggaacgagc  tgccaatga  tttgcacaa  cagaagctt  catgttgga  gggaacaac  1740
acctggagg  cgactcgag  gtgagtgaa  acctggatg  ggactggag  ctatttgat  1800
gttttgcgg  tggacttgg  gttgctgaa  ctatttcct  cgtggatcc  cagttcctc  1860
cctacatgg  actagaaga  cgcttagcc  aggctatgg  gactgcact  gcacactta  1920
agtctcttg  tgtagacgt  gaggtggct  acccacctg  cagtaagga  agcatcgac  1980
gacttccag  aacccttgt  ctagaagat  acaccgcta  tggtcagga  cagtgctgt  2040
ccatctgct  cagtgagta  attaaggat  acatcgcaa  agagctgcc  tgccatcac  2100
tctttcata  gccttgtgt  tccatttgg  tacagaagt  cggaacgtg  cctgtgtgc  2160
gccgccact  cccacctgc  gtgattgac  catctgcag  tgcttcctc  gaaccagac  2220
ttgatgcct  gcctgcaaa  gacaatgct  aggaagccc  gtaagccgt  acggggaaa  2280
gagatcgaa  ttctatcac  gtaaatctg  aaattcctt  taaatctga  gtgcaaata  2340
ttatatata  atatattta  aatgctcta  atagtatat  ccgtagttt  gaaagagaa  2400
attaacctt  ctaaactga  tttaggttt  cagaagata  taaacattt  caagctgaa  2460
gttgaagca  tgcatccat  ttctttagt  gaacatggt  tccattgta  cgtcagtag  2520
catctctgt  gcatacgtt  ctgttttgt  tgaagtgct  ccactaaga  atcagaatt  2580
agctctcct  tccacatca  atgtgaaag  agagcttaa  tctgatctc  gtggcatac  2640
tttctgttt  gtctgaagt  ctgccacta  gagatcaga  ttaagctct  ctttccaca  2700
cagatgtga  aactgtgat  acaacagta  tacagtttg  tttcattga  aataaactg  2760
attctaaag  atgcttttt  actggtccc  ttgcttttg  tacttcgag  cctcttggt  2820
tatataaca  tgaggttaa  attaaagct  ttcagaatg  caggcaaag  ctagagttt  2880
gacccgaac  cacacacaa  ataaaaaaa  aaaaaataa  ttacatctt  gatgtaaac  2940
tcctgaaac  gtcatgtaa  aaactattc  gtgaacgtt  gatgtttaa  ggctagtaa  3000
gcatgtgaa  tatctgatg  gcttcatgc  cggcacagt  tcatgagct  ggcctatga  3060
acactgtct  agccctcat  cagtctgct  ctacttgtt  aacactgaa  gtccagacc  3120
gtcttggca  ctgattaag  aattggatg  agttagcta  ggtagtttg  gttctactt  3180
aggagatct  aagatttgc  catggccat  tctgttaca  catcacccc  gattagaaa  3240
gcacagctt  taggtggtc  cacgagtag  caagtctgt  cagacgctg  tgtgatagg  3300
agcttacag  tgagccctg  catcagcac  gggacaacg  ctcagcagg  ccagcactg  3360
agcccatcc  cgtgcacat  tacctgccc  gctcatcca  ttcgggaat  tttctatag  3420
ttcccaaat  agcttcatc  gatttgtgt  atatatctg  gtatttata  tctttcttt  3480
ttctccagt  ttaaaaata  atgaatttt  actgttggc  catttgagg  ttaaatata  3540
gaaacctaa  acttgcatt  tgatttttg  atatattgt  aatgtggct  gtatttaca  3600
cgaatcctg  gtgtccttt  atgggtaaa  caaaagtga  cattgcatg  aagtaatgt  3660
gtgaatttg  aatttaggg  ttttctggg  cttctgtga  tgtggatgc  taaattcag  3720
ccttaatgt  gctctagct  gcatgtttc  ttctaatgt  catagtcag  ctgtatcca  3780
taatctctg  ttgtcttct  ctccgtggt  ttcacaccg  atccactga  ggtcagtta  3840
tgtcagagg  cacccaggt  agcatcagt  cccatgtgt  ccgtgcgga  tgtgagccg  3900
gtggttgct  ggttggttt  cttttatgt  ctttgatta  ctgtggcac  tactgagta  3960
acttacgtt  ctgcagact  ctgtgtaac  agccacgtt  tgtgtttag  cagtattac  4020
cacgggacc  tgttttatt  ttctagata  cagctgtcc  aaagaaaat  tttcttctt  4080
gcctattaa  atttagcta  tatctgcca  ttgttaagg  gtttgattc  aaactcaac  4140
agagttgaa  gtaagaaag  tgctgtact  ttgctgtcc  tctgttacg  cctccgttg  4200
tggctcctg  ctacgtacc  acggctgct  aaggagact  gttttaatt  gttttaaaa  4260
ggaaaatga  gttttagga  tttgatggt  gggaagctg  caagttcag  ccccagtct  4320
tcatttgct  ttagcttgg  tccttttga  aagttaaga  tatatgaag  taaattaga  4380
aaagtaaaa  tattgataa  atgtcattt  tcttatgtc  attttatgt  gttatttgg  4440
ctattaatt  taatttttt  aacattttc  tatttcttg  aatatgaat  ccgatattt  4500
aagtttgac  cacttgggt  tcttttgtg  ttcttagtt  ttatctcta  gcctaacta  4560
cttttaaga  tatttgtga  atggattta  ataagctgt  aaatatata  gagctgtta  4620
aatggaatg  aaggttttc  aaagaccag  tctaactgt  atgattggt  tattgttct  4680
caatcccag  ccggcattt  ccgtgtaaa  cataaacaa  aaacaggat  tactcagtg  4740
tcatttcta  aaaaaaaa  4758



<210> 2002
<211> 707
<212> PRT
<213> Rattus norvegicus
<308> BAA06979
<400> 2002

Met Ser Gln Tyr Thr Glu Lys Glu Pro Ser Val Met Asp Gln Asp Ser 
  1               5                  10                  15
Ser Lys Ala Ala Trp Pro Arg Ala Ala Gly Gly Tyr Gln Thr Ile Thr 
             20                  25                  30
Gly Arg Arg Tyr Gly Arg Arg His Ala Tyr Val Ser Phe Lys Pro Cys 
         35                  40                  45
Met Thr Arg His Glu Arg Ser Leu Gly Arg Ala Gly Asp Asp Tyr Glu 
     50                  55                  60
Val Leu Glu Leu Asp Asp Val Ala Lys Glu Asn Thr Ala Gly Ser Ser 
 65                  70                  75                  80
Ser Leu Asp Gln Val His Pro Ser Leu Pro Ser Glu Thr Thr Val Glu 
                 85                  90                  95
Lys Ser Glu Thr Glu Ile Pro Thr Cys Gly Pro Ala Leu Asn Gln Ser 
             100                105                110
Thr Glu Ser Asn Pro Ser Val Ala Thr Val Cys His Ser Glu Glu Val 
         115                120                125
Arg Glu Thr Leu Asp Ser Ser Thr Asn Leu Gln Asn His Ala Glu Arg 
     130                135                140
Glu Cys Thr Pro Ala Val Cys Asn Ala Ser Ser Val Gln Asn Gly Ile 
 145                150                155                160
Val Leu Val His Thr Asp Ser Tyr Asp Pro Asp Ser Lys His Asp Glu 
                 165                170                175
Asn Asp Ser Leu Gln Leu Cys Ala Gln Ala Val Glu Gly Gly Arg Arg 
             180                185                190
Gln Lys Val Leu Gly Asn Ala Val Phe Glu Leu Glu Asn Gly Glu Val 
         195                200                205
Glu Arg Tyr Ala Asp Leu Cys Pro Ser Val Pro Ser Leu Ser Gly Glu 
     210                215                220
Ile Arg Glu Glu Ser Glu Glu Leu Gly Ser Ala Leu Leu Glu Lys Asn 
 225                230                235                240
Ser Ala Gly Asp Ala Glu Ala Val His Gln Asp Gly Gln Glu Phe Gln 
                 245                250                255
Arg Ser Ser Glu Asp Gly Ile Val Arg Lys Arg Arg Gln Asp Asp Thr 
             260                265                270
Asp Gln Gly Arg Gln Thr Glu Asn Ser Thr Glu Asp Ala Asp Cys Val 
         275                280                285
Pro Gly His Val Glu Gln Asn Thr Ser Glu Arg Ala Asn His His Gly 
     290                295                300
Ser Ser Pro Glu Gln Val Val Arg Pro Lys Val Arg Lys Val Ile Ser 
 305                310                315                320
Ser Ser Gln Val Asp Gln Glu Ser Gly Phe Asn Arg His Glu Ala Lys 
                 325                330                335
Gln Arg Ser Val Gln Arg Trp Arg Glu Ala Leu Glu Val Glu Glu Cys 
             340                345                350
Ser Ser Asp Asp Pro Ile Ile Lys Cys Asp Asp Tyr Asp Gly Asp His 
         355                360                365
Asp Cys Met Phe Leu Thr Pro Ser Tyr Ser Arg Val Thr Pro Arg Glu 
     370                375                380
Ala Glu Arg His Arg Ala Thr Ala Glu Asn Gly Ala Thr Ala Ser Gly 
 385                390                395                400
Arg Gln Glu Ala Arg Glu Asn Ala Phe Trp Asn Ala Cys Gly Glu Tyr 
                 405                410                415
Tyr Gln Leu Phe Asp Lys Asp Glu Asp Ser Ser Glu Cys Ser Asp Gly 
             420                425                430
Glu Trp Ser Ala Ser Leu Pro His Arg Phe Ser Gly Thr Glu Lys Asp 
         435                440                445
Gln Ser Ser Ser Asp Glu Ser Trp Glu Thr Leu Pro Gly Lys Asp Glu 
     450                455                460
Asn Glu Pro Glu Leu Gln Ser Asp Ser Ser Gly Pro Glu Glu Glu Asn 
 465                470                475                480
Gln Glu Leu Ser Leu Gln Glu Gly Glu Gln Thr Ser Leu Glu Glu Gly 
                 485                490                495
Glu Ile Pro Trp Leu Gln Tyr Asn Glu Val Asn Glu Ser Ser Ser Asp 
             500                505                510
Glu Gly Asn Glu Pro Ala Asn Glu Phe Ala Gln Pro Glu Ala Phe Met 
         515                520                525
Leu Asp Gly Asn Asn Asn Leu Glu Asp Asp Ser Ser Val Ser Glu Asp 
     530                535                540
Leu Asp Val Asp Trp Ser Leu Phe Asp Gly Phe Ala Asp Gly Leu Gly 
 545                550                555                560
Val Ala Glu Ala Ile Ser Tyr Val Asp Pro Gln Phe Leu Thr Tyr Met 
                 565                570                575
Ala Leu Glu Glu Arg Leu Ala Gln Ala Met Glu Thr Ala Leu Ala His 
             580                585                590
Leu Glu Ser Leu Ala Val Asp Val Glu Val Ala Asn Pro Pro Ala Ser 
         595                600                605
Lys Glu Ser Ile Asp Gly Leu Pro Glu Thr Leu Val Leu Glu Asp His 
     610                615                620
Thr Ala Ile Gly Gln Glu Gln Cys Cys Pro Ile Cys Cys Ser Glu Tyr 
 625                630                635                640
Ile Lys Asp Asp Ile Ala Thr Glu Leu Pro Cys His His Phe Phe His 
                 645                650                655
Lys Pro Cys Val Ser Ile Trp Leu Gln Lys Ser Gly Thr Cys Pro Val 
             660                665                670
Cys Arg Arg His Phe Pro Pro Ala Val Ile Asp Ala Ser Ala Ala Ala 
         675                680                685
Ser Ser Glu Pro Asp Leu Asp Ala Ser Pro Ala Asn Asp Asn Ala Glu 
     690                695                700
Glu Ala Pro 
 705



<210> 2003
<211> 4765
<212> DNA
<213> Homo sapiens
<308> AB007898
<400> 2003

gttctcgct  cggagccgc  gcacatttc  gaatcttct  cggcttgtc  atagtgtga  60
taaaaacta  atcacatct  taattctac  gaactggtc  tacagacgc  gccatatat  120
tcacagtac  ctgaaaagg  gccagcagc  atggaccaa  aatctggta  ggctgtctg  180
cccaaacca  caggagggt  tcagacaat  acaggcagg  gatatggaa  aagacatgc  240
tatgtcagt  ttaaaccat  tatgaccag  catgaaaga  gcttaggtc  ggctggtga  300
gactatgaa  tgttggaac  agatgatgt  ccaaaggaa  attcctcag  ttccagtcc  360
ttggatcaa  ttgattctt  tttacccag  gaacctata  ttgaaaaaa  tgaaacaga  420
attcccact  gtggttcag  attgaatca  accactgag  gcagtcaat  ctttgttgc  480
gtacatcac  gtgaggaag  cagggatac  ttaggaagc  gtacaaatc  tcataatca  540
tctgaggga  agtatattc  aggagcttg  agtgcttca  gtgtccaaa  tggaattgc  600
ttggttcat  cagactctt  tgatccaga  ggcaaacat  gagaagata  tgaccatct  660
caactttct  cagaagtcg  ggaaggtag  agataccag  aatcattag  caatacagt  720
tttgagttg  aaaacagag  ggcagaggc  tacactggt  tttcaccac  agttccctc  780
tttaactgt  aagtaagag  tgagtttga  gagttagat  ctgtaccat  agtgaaaag  840
tctgctggt  atactgagt  tgtccatca  aatagccag  aaattcaga  gtcttctca  900
gatgaaatg  ttagtacga  acaacaaaa  aatactagc  aggaaagac  gacagaaca  960
tcacctgaa  atgcagcct  tggtccagg  catatttgt  gtgaacgaa  taccaatga  1020
agggaaaag  accatggaa  ttctcctga  caggtagtg  ggccaaaag  tagaaaact  1080
ataagttca  gccaggtgg  ccaagaaac  ggttttaat  ggcatgagg  gaaacaaag  1140
agtgttcaa  gatggagag  ggctttgga  gttgaggaa  gtggctcag  tgacctctt  1200
ataaaatgt  aagaatatg  tggagagca  gactgtatg  tcttggatc  accatactc  1260
agagttatt  cacaaaggg  aacagaaaa  aaccaaatg  catcagaaa  tggagccac  1320
gcgggaagg  aagaagtgg  taacacctt  tggaatggc  gtggagatt  ttaccaact  1380
tatgacaaa  atgaagata  ttctgaatg  agtgatggg  aatggtctg  ttctttgcc  1440
catcgattt  ctggtacag  aaaagatca  tcctcaagt  atgaaagct  ggagactct  1500
ccaggaaaa  atgagaatg  acctgagct  caaagtgat  gcagtggcc  tgaagaaga  1560
aaccaagaa  tatctcttc  ggaagggga  cagacatcc  tggaagagg  agaaattcc  1620
tggttacag  acaatgaag  caatgaaag  agcagtgat  agggaaatg  acctgccaa  1680
gaatttgca  agccagctt  catgttgga  ggtaacaat  acctggagg  tgactccag  1740
gtgagtgaa  acttagatg  ggattggag  ctatttgat  gctttgcag  tggactagg  1800
gttgctgaa  ctatttcat  tgtggatcc  cagttcctt  cctacatgg  actagaaga  1860
cgcttagcc  aggctatgg  gactgctct  gcccattta  agtctcttg  agtggatgt  1920
gaggtggcc  atccaccag  tagtaagga  agcattgat  gtcttccag  gacccttgt  1980
cttgaagat  acactgcta  tggtcagga  caatgctgt  caatctgtt  cagtgagta  2040
attaaggat  atatagcaa  agagttgcc  tgtcaccat  tctttcaca  accttgtgt  2100
tcaatttgg  tacaaaagt  gggaacatg  cctgtgtgc  gccgtcatt  cccacctgc  2160
gttattgaa  catctgcag  tccttcctc  gagcctgat  ctgatgccc  accttcaaa  2220
gacagtatt  cagaagcac  ctaaacctt  acagttgaa  tgagatcag  gtatcaaag  2280
aaatctgca  attccttct  aatttcatg  gcaaataat  atatataaa  atatttaaa  2340
atgctatat  tagtatatg  catagttta  aaagaatat  aacctttct  aactaaatt  2400
aggtttgca  aaagtatta  acattttta  gctgaatgt  gagacagtg  atccatttt  2460
tttagttga  tatgtttgt  ttaattgta  agccaagct  atcagttga  tctctccag  2520
ataaataat  atctgtgtg  catacgtta  tggctttgt  tgtaatact  ccactaagt  2580
attataatt  agctgtcct  tttgcatca  atgtaaaga  tgtgttcac  accgtagta  2640
aatttggtt  cattggaaa  gaaacaaat  ctaaagtat  ctttttcac  agtcccttt  2700
attttgcta  atcataacc  cttggttca  atgctgaga  atttttcag  aagtccatt  2760
ttgtttaaa  ttagaactt  tcagaatgc  aaatgaagg  taaaatttt  gccagaaca  2820
tacaaaagt  ttaaatcgt  gacgtaact  cccctgaaa  aaagttagg  agtaaaatc  2880
ttaatgaaa  cagtggatg  gcttaacgt  aggttagta  agcatacaa  gaatctagt  2940
tgctcaggg  ttggtacaa  gagctgaat  agatggcct  atgaaactc  ttctaacct  3000
ttacccaac  tgtttctcc  tggttaaaa  tatacttga  ggcccagaa  actcatggc  3060
catttgttt  atattgctt  tagttagtt  aaggtaatt  tgcttctac  gtattttgg  3120
aggtctgaa  acttgcaca  ggtcatctt  gtaattata  aaccccaaa  taagatgca  3180
aatgtctcc  tcaggtgat  acacacagt  gacgagtat  tgcaaacat  gacataata  3240
ttcacttac  aatgtgatt  gatgttaac  ctagagaat  atgactgta  aacatttga  3300
caagtaaaa  agtaaagca  atagtgagt  tatgtccgt  taactggta  attgataat  3360
tagtttggg  acataaaag  aatatttat  tggcttccc  aatgcagag  tacatctta  3420
tcgtgtatt  ctctgagta  ttatatccc  tctcctttt  tcattctta  aaataaatg  3480
attttcact  ttggcacat  tgaggctta  atataagga  cataacact  gcattctaa  3540
ttttgcata  attgtaaat  tgtctggta  ttacagcaa  atactgtgt  tccttttat  3600
ggtaaaaca  aagtgaaca  tgcatgcat  taatgtgat  aatttgtaa  ttaggagtt  3660
tttggggct  ctgtgactt  ggaaatgct  acattcagg  cttaatgtt  cattagcta  3720
catgttttc  ctctgatgt  tatagtcac  gttgtataa  ctaatcttt  cttgttttc  3780
actctgtga  ctttccata  catatttca  taatgatca  ttagtgtca  ggagtcaaa  3840
cagattaaa  ttaatttca  gtgtatatg  tggaaattt  tggctagtg  gatttttgt  3900
tgtttcctt  taagtactg  tgatcagtt  tgacactta  tggttaaac  tacgttgct  3960
aagatttct  tataataag  cacacatta  atttagact  tattaaggg  ccttggttt  4020
cttctagat  gcagctgtc  caaagaaaa  atttcttct  tgtctgtta  gatttagct  4080
ttatctgcc  gttgttaag  ggttttggt  ccaaactca  ccagcaatg  tgagagctg  4140
acttaagat  gctgttgta  tttttgctt  ccatctgtt  ctgtccttc  ttcttggct  4200
cctactatc  ataaacagc  gctgtgaag  agaaaagtt  aataagagt  ggcttaaat  4260
ttaaaaaag  aaaagaaaa  tgaggtttt  ggattttca  ggtaacaag  tctggtata  4320
gctaaggct  gcaagttca  atactaaaa  attatttga  catatcttg  atccttttg  4380
aaaagttaa  actatatga  ggtaaatta  aaataagta  gaatattaa  aaaatagca  4440
ttatcttat  tctctattt  atgttgtga  ttaacctaa  tttattttt  taacatttt  4500
ttatttctt  taatatgaa  gctgatatt  aaaggtaga  ctatgtggt  ttctttgtg  4560
ttcttaatt  tttaactct  aagattatt  gtgatctgg  tttatgtat  tgttagata  4620
atacgaatt  ttaaaatgg  atgcaagtt  ttcaaaagc  caggtctaa  tgtaatggt  4680
ggtttattg  tctataacc  cagcccatc  ttttctgtg  aaatcataa  caataaaca  4740
aatatactc  gtggtcatt  ctaat  4765



<210> 2004
<211> 708
<212> PRT
<213> Homo sapiens
<308> XP_003693
<400> 2004

Met Ser Gln Tyr Thr Glu Lys Glu Pro Ala Ala Met Asp Gln Glu Ser 
  1               5                  10                  15
Gly Lys Ala Val Trp Pro Lys Pro Ala Gly Gly Tyr Gln Thr Ile Thr 
             20                  25                  30
Gly Arg Arg Tyr Gly Arg Arg His Ala Tyr Val Ser Phe Lys Pro Cys 
         35                  40                  45
Met Thr Arg His Glu Arg Ser Leu Gly Arg Ala Gly Asp Asp Tyr Glu 
     50                  55                  60
Val Leu Glu Leu Asp Asp Val Pro Lys Glu Asn Ser Ser Gly Ser Ser 
 65                  70                  75                  80
Pro Leu Asp Gln Val Asp Ser Ser Leu Pro Ser Glu Pro Ile Phe Glu 
                 85                  90                  95
Lys Ser Glu Thr Glu Ile Pro Thr Cys Gly Ser Ala Leu Asn Gln Thr 
             100                105                110
Thr Glu Ser Ser Gln Ser Phe Val Ala Val His His Ser Glu Glu Gly 
         115                120                125
Arg Asp Thr Leu Gly Ser Ser Thr Asn Leu His Asn His Ser Glu Gly 
     130                135                140
Glu Tyr Ile Pro Gly Ala Cys Ser Ala Ser Ser Val Gln Asn Gly Ile 
 145                150                155                160
Ala Leu Val His Thr Asp Ser Tyr Asp Pro Asp Gly Lys His Gly Glu 
                 165                170                175
Asp Asn Asp His Leu Gln Leu Ser Ala Glu Val Val Glu Gly Ser Arg 
             180                185                190
Tyr Gln Glu Ser Leu Gly Asn Thr Val Phe Glu Leu Glu Asn Arg Glu 
         195                200                205
Ala Glu Ala Tyr Thr Gly Leu Ser Pro Pro Val Pro Ser Phe Asn Cys 
     210                215                220
Glu Val Arg Asp Glu Phe Glu Glu Leu Asp Ser Val Pro Leu Val Lys 
 225                230                235                240
Ser Ser Ala Gly Asp Thr Glu Phe Val His Gln Asn Ser Gln Glu Ile 
                 245                250                255
Gln Arg Ser Ser Gln Asp Glu Met Val Ser Thr Lys Gln Gln Asn Asn 
             260                265                270
Thr Ser Gln Glu Arg Gln Thr Glu His Ser Pro Glu Asp Ala Ala Cys 
         275                280                285
Gly Pro Gly His Ile Cys Ser Glu Gln Asn Thr Asn Asp Arg Glu Lys 
     290                295                300
Asn His Gly Ser Ser Pro Glu Gln Val Val Arg Pro Lys Val Arg Lys 
 305                310                315                320
Leu Ile Ser Ser Ser Gln Val Asp Gln Glu Thr Gly Phe Asn Arg His 
                 325                330                335
Glu Ala Lys Gln Arg Ser Val Gln Arg Trp Arg Glu Ala Leu Glu Val 
             340                345                350
Glu Glu Ser Gly Ser Asp Asp Leu Leu Ile Lys Cys Glu Glu Tyr Asp 
         355                360                365
Gly Glu His Asp Cys Met Phe Leu Asp Pro Pro Tyr Ser Arg Val Ile 
     370                375                380
Thr Gln Arg Glu Thr Glu Asn Asn Gln Met Thr Ser Glu Ser Gly Ala 
 385                390                395                400
Thr Ala Gly Arg Gln Glu Val Asp Asn Thr Phe Trp Asn Gly Cys Gly 
                 405                410                415
Asp Tyr Tyr Gln Leu Tyr Asp Lys Asp Glu Asp Ser Ser Glu Cys Ser 
             420                425                430
Asp Gly Glu Trp Ser Ala Ser Leu Pro His Arg Phe Ser Gly Thr Glu 
         435                440                445
Lys Asp Gln Ser Ser Ser Asp Glu Ser Trp Glu Thr Leu Pro Gly Lys 
     450                455                460
Asp Glu Asn Glu Pro Glu Leu Gln Ser Asp Ser Ser Gly Pro Glu Glu 
 465                470                475                480
Glu Asn Gln Glu Leu Ser Leu Gln Glu Gly Glu Gln Thr Ser Leu Glu 
                 485                490                495
Glu Gly Glu Ile Pro Trp Leu Gln Tyr Asn Glu Val Asn Glu Ser Ser 
             500                505                510
Ser Asp Glu Gly Asn Glu Pro Ala Asn Glu Phe Ala Gln Pro Ala Phe 
         515                520                525
Met Leu Asp Gly Asn Asn Asn Leu Glu Asp Asp Ser Ser Val Ser Glu 
     530                535                540
Asp Leu Asp Val Asp Trp Ser Leu Phe Asp Gly Phe Ala Asp Gly Leu 
 545                550                555                560
Gly Val Ala Glu Ala Ile Ser Tyr Val Asp Pro Gln Phe Leu Thr Tyr 
                 565                570                575
Met Ala Leu Glu Glu Arg Leu Ala Gln Ala Met Glu Thr Ala Leu Ala 
             580                585                590
His Leu Glu Ser Leu Ala Val Asp Val Glu Val Ala Asn Pro Pro Ala 
         595                600                605
Ser Lys Glu Ser Ile Asp Gly Leu Pro Glu Thr Leu Val Leu Glu Asp 
     610                615                620
His Thr Ala Ile Gly Gln Glu Gln Cys Cys Pro Ile Cys Cys Ser Glu 
 625                630                635                640
Tyr Ile Lys Asp Asp Ile Ala Thr Glu Leu Pro Cys His His Phe Phe 
                 645                650                655
His Lys Pro Cys Val Ser Ile Trp Leu Gln Lys Ser Gly Thr Cys Pro 
             660                665                670
Val Cys Arg Arg His Phe Pro Pro Ala Val Ile Glu Ala Ser Ala Ala 
         675                680                685
Pro Ser Ser Glu Pro Asp Pro Asp Ala Pro Pro Ser Asn Asp Ser Ile 
     690                695                700
Thr Glu Ala Pro 
 705



<210> 2005
<211> 4758
<212> DNA
<213> Rattus norvegicus
<308> D32249
<400> 2005

tggcgggtg  aggatcgag  gctgttctc  ctctggagc  gctgcacat  tcggaatca  60
ttgcagctt  ttcactgtg  aaggaaaaa  caaattaca  ccataattc  attgaactg  120
aagcataga  gctgccata  atgtcacag  atacagaaa  agaaccatc  gtaatggat  180
aagactcca  caaggctgc  tggcctaga  cagcaggag  ataccagac  attacaggc  240
ggaggtacg  aaggagaca  gcgtatgtc  gttttaagc  atgtatgac  aggcatgaa  300
ggagcttgg  tcgggctgg  gatgactat  aagttctgg  actggatga  gttgccaag  360
aaaacaccg  aggttccag  tcattggat  aagtccatc  ttctttacc  agtgaaact  420
cagttgaaa  aagtgaaac  gaaattcct  cttgtggtc  agcactgaa  caaagcacg  480
agagcaacc  atccgttgc  acagtgtgt  atagtgagg  agtcaggga  accttagac  540
gcagtacga  tcttcagaa  cacgctgag  gagagtgta  gccagcagt  tgtaatgcc  600
caagtgtcc  gaatggaat  gtgttggtt  atactgact  ttatgatcc  gacagcaag  660
atgatgaga  tgactctct  caactttgt  cccaagctg  ggaaggtgg  agacgtcag  720
aggtattag  caatgcagt  tttgagctg  aaaatggag  ggtagagag  tatgctgat  780
tgtgtccct  agttccctc  ctcagtggt  aaataaggg  ggagtctga  gagctaggt  840
cagcactct  agagaaaaa  tctgctggc  atgcggagg  tgtccatca  gatgggcag  900
aatttcaga  gtcttctga  gacggcatt  ttagaaaga  gcgacaaga  gataccgat  960
agggaagac  gacagaaaa  tcaactgaa  atgcagact  tgttccagg  catgttgaa  1020
aaaatacta  tgagagagc  aatcaccat  gaagttctc  tgaacaggt  gtgaggccc  1080
aagttagaa  agtgatcag  tcaagccag  tggaccaag  gagcggttt  aataggcac  1140
aggctaagc  aagaagtgt  cagaggtgg  gagaggctc  ggaagttga  gaatgcagt  1200
cagatgacc  tataatcaa  tgtgacgat  atgatggag  ccatgactg  atgttccta  1260
ccccatcct  ctcaagagt  acgccaagg  aagcagaac  tcaccgtgc  acagcagaa  1320
atggagcca  agcttcagg  aggcaagag  ctcgggaaa  tgccttttg  aatgcctgt  1380
gagagtatt  ccagctctt  gacaaagac  aagacagtt  agagtgcag  gatggggaa  1440
ggtctgctt  tctgcctca  cgattttct  gcacagaaa  agaccagtc  tcaagcgat  1500
aaagctggg  aactctgcc  ggaaaagat  agaatgaac  tgagctaca  agtgatagt  1560
gtggccctg  ggaagaaaa  caagaattg  ctcttcagg  gggagaaca  acgtccttg  1620
aggaggggg  gattccctg  ttacagtac  atgaggtca  tgagagcag  agcgatgaa  1680
ggaacgagc  tgccaatga  tttgcacaa  cagaagctt  catgttgga  gggaacaac  1740
acctggagg  cgactcgag  gtgagtgaa  acctggatg  ggactggag  ctatttgat  1800
gttttgcgg  tggacttgg  gttgctgaa  ctatttcct  cgtggatcc  cagttcctc  1860
cctacatgg  actagaaga  cgcttagcc  aggctatgg  gactgcact  gcacactta  1920
agtctcttg  tgtagacgt  gaggtggct  acccacctg  cagtaagga  agcatcgac  1980
gacttccag  aacccttgt  ctagaagat  acaccgcta  tggtcagga  cagtgctgt  2040
ccatctgct  cagtgagta  attaaggat  acatcgcaa  agagctgcc  tgccatcac  2100
tctttcata  gccttgtgt  tccatttgg  tacagaagt  cggaacgtg  cctgtgtgc  2160
gccgccact  cccacctgc  gtgattgac  catctgcag  tgcttcctc  gaaccagac  2220
ttgatgcct  gcctgcaaa  gacaatgct  aggaagccc  gtaagccgt  acggggaaa  2280
gagatcgaa  ttctatcac  gtaaatctg  aaattcctt  taaatctga  gtgcaaata  2340
ttatatata  atatattta  aatgctcta  atagtatat  ccgtagttt  gaaagagaa  2400
attaacctt  ctaaactga  tttaggttt  cagaagata  taaacattt  caagctgaa  2460
gttgaagca  tgcatccat  ttctttagt  gaacatggt  tccattgta  cgtcagtag  2520
catctctgt  gcatacgtt  ctgttttgt  tgaagtgct  ccactaaga  atcagaatt  2580
agctctcct  tccacatca  atgtgaaag  agagcttaa  tctgatctc  gtggcatac  2640
tttctgttt  gtctgaagt  ctgccacta  gagatcaga  ttaagctct  ctttccaca  2700
cagatgtga  aactgtgat  acaacagta  tacagtttg  tttcattga  aataaactg  2760
attctaaag  atgcttttt  actggtccc  ttgcttttg  tacttcgag  cctcttggt  2820
tatataaca  tgaggttaa  attaaagct  ttcagaatg  caggcaaag  ctagagttt  2880
gacccgaac  cacacacaa  ataaaaaaa  aaaaaataa  ttacatctt  gatgtaaac  2940
tcctgaaac  gtcatgtaa  aaactattc  gtgaacgtt  gatgtttaa  ggctagtaa  3000
gcatgtgaa  tatctgatg  gcttcatgc  cggcacagt  tcatgagct  ggcctatga  3060
acactgtct  agccctcat  cagtctgct  ctacttgtt  aacactgaa  gtccagacc  3120
gtcttggca  ctgattaag  aattggatg  agttagcta  ggtagtttg  gttctactt  3180
aggagatct  aagatttgc  catggccat  tctgttaca  catcacccc  gattagaaa  3240
gcacagctt  taggtggtc  cacgagtag  caagtctgt  cagacgctg  tgtgatagg  3300
agcttacag  tgagccctg  catcagcac  gggacaacg  ctcagcagg  ccagcactg  3360
agcccatcc  cgtgcacat  tacctgccc  gctcatcca  ttcgggaat  tttctatag  3420
ttcccaaat  agcttcatc  gatttgtgt  atatatctg  gtatttata  tctttcttt  3480
ttctccagt  ttaaaaata  atgaatttt  actgttggc  catttgagg  ttaaatata  3540
gaaacctaa  acttgcatt  tgatttttg  atatattgt  aatgtggct  gtatttaca  3600
cgaatcctg  gtgtccttt  atgggtaaa  caaaagtga  cattgcatg  aagtaatgt  3660
gtgaatttg  aatttaggg  ttttctggg  cttctgtga  tgtggatgc  taaattcag  3720
ccttaatgt  gctctagct  gcatgtttc  ttctaatgt  catagtcag  ctgtatcca  3780
taatctctg  ttgtcttct  ctccgtggt  ttcacaccg  atccactga  ggtcagtta  3840
tgtcagagg  cacccaggt  agcatcagt  cccatgtgt  ccgtgcgga  tgtgagccg  3900
gtggttgct  ggttggttt  cttttatgt  ctttgatta  ctgtggcac  tactgagta  3960
acttacgtt  ctgcagact  ctgtgtaac  agccacgtt  tgtgtttag  cagtattac  4020
cacgggacc  tgttttatt  ttctagata  cagctgtcc  aaagaaaat  tttcttctt  4080
gcctattaa  atttagcta  tatctgcca  ttgttaagg  gtttgattc  aaactcaac  4140
agagttgaa  gtaagaaag  tgctgtact  ttgctgtcc  tctgttacg  cctccgttg  4200
tggctcctg  ctacgtacc  acggctgct  aaggagact  gttttaatt  gttttaaaa  4260
ggaaaatga  gttttagga  tttgatggt  gggaagctg  caagttcag  ccccagtct  4320
tcatttgct  ttagcttgg  tccttttga  aagttaaga  tatatgaag  taaattaga  4380
aaagtaaaa  tattgataa  atgtcattt  tcttatgtc  attttatgt  gttatttgg  4440
ctattaatt  taatttttt  aacattttc  tatttcttg  aatatgaat  ccgatattt  4500
aagtttgac  cacttgggt  tcttttgtg  ttcttagtt  ttatctcta  gcctaacta  4560
cttttaaga  tatttgtga  atggattta  ataagctgt  aaatatata  gagctgtta  4620
aatggaatg  aaggttttc  aaagaccag  tctaactgt  atgattggt  tattgttct  4680
caatcccag  ccggcattt  ccgtgtaaa  cataaacaa  aaacaggat  tactcagtg  4740
tcatttcta  aaaaaaaa  4758



<210> 2006
<211> 707
<212> PRT
<213> Rattus norvegicus
<308> BAA06979
<400> 2006

Met Ser Gln Tyr Thr Glu Lys Glu Pro Ser Val Met Asp Gln Asp Ser 
  1               5                  10                  15
Ser Lys Ala Ala Trp Pro Arg Ala Ala Gly Gly Tyr Gln Thr Ile Thr 
             20                  25                  30
Gly Arg Arg Tyr Gly Arg Arg His Ala Tyr Val Ser Phe Lys Pro Cys 
         35                  40                  45
Met Thr Arg His Glu Arg Ser Leu Gly Arg Ala Gly Asp Asp Tyr Glu 
     50                  55                  60
Val Leu Glu Leu Asp Asp Val Ala Lys Glu Asn Thr Ala Gly Ser Ser 
 65                  70                  75                  80
Ser Leu Asp Gln Val His Pro Ser Leu Pro Ser Glu Thr Thr Val Glu 
                 85                  90                  95
Lys Ser Glu Thr Glu Ile Pro Thr Cys Gly Pro Ala Leu Asn Gln Ser 
             100                105                110
Thr Glu Ser Asn Pro Ser Val Ala Thr Val Cys His Ser Glu Glu Val 
         115                120                125
Arg Glu Thr Leu Asp Ser Ser Thr Asn Leu Gln Asn His Ala Glu Arg 
     130                135                140
Glu Cys Thr Pro Ala Val Cys Asn Ala Ser Ser Val Gln Asn Gly Ile 
 145                150                155                160
Val Leu Val His Thr Asp Ser Tyr Asp Pro Asp Ser Lys His Asp Glu 
                 165                170                175
Asn Asp Ser Leu Gln Leu Cys Ala Gln Ala Val Glu Gly Gly Arg Arg 
             180                185                190
Gln Lys Val Leu Gly Asn Ala Val Phe Glu Leu Glu Asn Gly Glu Val 
         195                200                205
Glu Arg Tyr Ala Asp Leu Cys Pro Ser Val Pro Ser Leu Ser Gly Glu 
     210                215                220
Ile Arg Glu Glu Ser Glu Glu Leu Gly Ser Ala Leu Leu Glu Lys Asn 
 225                230                235                240
Ser Ala Gly Asp Ala Glu Ala Val His Gln Asp Gly Gln Glu Phe Gln 
                 245                250                255
Arg Ser Ser Glu Asp Gly Ile Val Arg Lys Arg Arg Gln Asp Asp Thr 
             260                265                270
Asp Gln Gly Arg Gln Thr Glu Asn Ser Thr Glu Asp Ala Asp Cys Val 
         275                280                285
Pro Gly His Val Glu Gln Asn Thr Ser Glu Arg Ala Asn His His Gly 
     290                295                300
Ser Ser Pro Glu Gln Val Val Arg Pro Lys Val Arg Lys Val Ile Ser 
 305                310                315                320
Ser Ser Gln Val Asp Gln Glu Ser Gly Phe Asn Arg His Glu Ala Lys 
                 325                330                335
Gln Arg Ser Val Gln Arg Trp Arg Glu Ala Leu Glu Val Glu Glu Cys 
             340                345                350
Ser Ser Asp Asp Pro Ile Ile Lys Cys Asp Asp Tyr Asp Gly Asp His 
         355                360                365
Asp Cys Met Phe Leu Thr Pro Ser Tyr Ser Arg Val Thr Pro Arg Glu 
     370                375                380
Ala Glu Arg His Arg Ala Thr Ala Glu Asn Gly Ala Thr Ala Ser Gly 
 385                390                395                400
Arg Gln Glu Ala Arg Glu Asn Ala Phe Trp Asn Ala Cys Gly Glu Tyr 
                 405                410                415
Tyr Gln Leu Phe Asp Lys Asp Glu Asp Ser Ser Glu Cys Ser Asp Gly 
             420                425                430
Glu Trp Ser Ala Ser Leu Pro His Arg Phe Ser Gly Thr Glu Lys Asp 
         435                440                445
Gln Ser Ser Ser Asp Glu Ser Trp Glu Thr Leu Pro Gly Lys Asp Glu 
     450                455                460
Asn Glu Pro Glu Leu Gln Ser Asp Ser Ser Gly Pro Glu Glu Glu Asn 
 465                470                475                480
Gln Glu Leu Ser Leu Gln Glu Gly Glu Gln Thr Ser Leu Glu Glu Gly 
                 485                490                495
Glu Ile Pro Trp Leu Gln Tyr Asn Glu Val Asn Glu Ser Ser Ser Asp 
             500                505                510
Glu Gly Asn Glu Pro Ala Asn Glu Phe Ala Gln Pro Glu Ala Phe Met 
         515                520                525
Leu Asp Gly Asn Asn Asn Leu Glu Asp Asp Ser Ser Val Ser Glu Asp 
     530                535                540
Leu Asp Val Asp Trp Ser Leu Phe Asp Gly Phe Ala Asp Gly Leu Gly 
 545                550                555                560
Val Ala Glu Ala Ile Ser Tyr Val Asp Pro Gln Phe Leu Thr Tyr Met 
                 565                570                575
Ala Leu Glu Glu Arg Leu Ala Gln Ala Met Glu Thr Ala Leu Ala His 
             580                585                590
Leu Glu Ser Leu Ala Val Asp Val Glu Val Ala Asn Pro Pro Ala Ser 
         595                600                605
Lys Glu Ser Ile Asp Gly Leu Pro Glu Thr Leu Val Leu Glu Asp His 
     610                615                620
Thr Ala Ile Gly Gln Glu Gln Cys Cys Pro Ile Cys Cys Ser Glu Tyr 
 625                630                635                640
Ile Lys Asp Asp Ile Ala Thr Glu Leu Pro Cys His His Phe Phe His 
                 645                650                655
Lys Pro Cys Val Ser Ile Trp Leu Gln Lys Ser Gly Thr Cys Pro Val 
             660                665                670
Cys Arg Arg His Phe Pro Pro Ala Val Ile Asp Ala Ser Ala Ala Ala 
         675                680                685
Ser Ser Glu Pro Asp Leu Asp Ala Ser Pro Ala Asn Asp Asn Ala Glu 
     690                695                700
Glu Ala Pro 
 705



<210> 2007
<211> 4765
<212> DNA
<213> Homo sapiens
<308> AB007898
<400> 2007

gttctcgct  cggagccgc  gcacatttc  gaatcttct  cggcttgtc  atagtgtga  60
taaaaacta  atcacatct  taattctac  gaactggtc  tacagacgc  gccatatat  120
tcacagtac  ctgaaaagg  gccagcagc  atggaccaa  aatctggta  ggctgtctg  180
cccaaacca  caggagggt  tcagacaat  acaggcagg  gatatggaa  aagacatgc  240
tatgtcagt  ttaaaccat  tatgaccag  catgaaaga  gcttaggtc  ggctggtga  300
gactatgaa  tgttggaac  agatgatgt  ccaaaggaa  attcctcag  ttccagtcc  360
ttggatcaa  ttgattctt  tttacccag  gaacctata  ttgaaaaaa  tgaaacaga  420
attcccact  gtggttcag  attgaatca  accactgag  gcagtcaat  ctttgttgc  480
gtacatcac  gtgaggaag  cagggatac  ttaggaagc  gtacaaatc  tcataatca  540
tctgaggga  agtatattc  aggagcttg  agtgcttca  gtgtccaaa  tggaattgc  600
ttggttcat  cagactctt  tgatccaga  ggcaaacat  gagaagata  tgaccatct  660
caactttct  cagaagtcg  ggaaggtag  agataccag  aatcattag  caatacagt  720
tttgagttg  aaaacagag  ggcagaggc  tacactggt  tttcaccac  agttccctc  780
tttaactgt  aagtaagag  tgagtttga  gagttagat  ctgtaccat  agtgaaaag  840
tctgctggt  atactgagt  tgtccatca  aatagccag  aaattcaga  gtcttctca  900
gatgaaatg  ttagtacga  acaacaaaa  aatactagc  aggaaagac  gacagaaca  960
tcacctgaa  atgcagcct  tggtccagg  catatttgt  gtgaacgaa  taccaatga  1020
agggaaaag  accatggaa  ttctcctga  caggtagtg  ggccaaaag  tagaaaact  1080
ataagttca  gccaggtgg  ccaagaaac  ggttttaat  ggcatgagg  gaaacaaag  1140
agtgttcaa  gatggagag  ggctttgga  gttgaggaa  gtggctcag  tgacctctt  1200
ataaaatgt  aagaatatg  tggagagca  gactgtatg  tcttggatc  accatactc  1260
agagttatt  cacaaaggg  aacagaaaa  aaccaaatg  catcagaaa  tggagccac  1320
gcgggaagg  aagaagtgg  taacacctt  tggaatggc  gtggagatt  ttaccaact  1380
tatgacaaa  atgaagata  ttctgaatg  agtgatggg  aatggtctg  ttctttgcc  1440
catcgattt  ctggtacag  aaaagatca  tcctcaagt  atgaaagct  ggagactct  1500
ccaggaaaa  atgagaatg  acctgagct  caaagtgat  gcagtggcc  tgaagaaga  1560
aaccaagaa  tatctcttc  ggaagggga  cagacatcc  tggaagagg  agaaattcc  1620
tggttacag  acaatgaag  caatgaaag  agcagtgat  agggaaatg  acctgccaa  1680
gaatttgca  agccagctt  catgttgga  ggtaacaat  acctggagg  tgactccag  1740
gtgagtgaa  acttagatg  ggattggag  ctatttgat  gctttgcag  tggactagg  1800
gttgctgaa  ctatttcat  tgtggatcc  cagttcctt  cctacatgg  actagaaga  1860
cgcttagcc  aggctatgg  gactgctct  gcccattta  agtctcttg  agtggatgt  1920
gaggtggcc  atccaccag  tagtaagga  agcattgat  gtcttccag  gacccttgt  1980
cttgaagat  acactgcta  tggtcagga  caatgctgt  caatctgtt  cagtgagta  2040
attaaggat  atatagcaa  agagttgcc  tgtcaccat  tctttcaca  accttgtgt  2100
tcaatttgg  tacaaaagt  gggaacatg  cctgtgtgc  gccgtcatt  cccacctgc  2160
gttattgaa  catctgcag  tccttcctc  gagcctgat  ctgatgccc  accttcaaa  2220
gacagtatt  cagaagcac  ctaaacctt  acagttgaa  tgagatcag  gtatcaaag  2280
aaatctgca  attccttct  aatttcatg  gcaaataat  atatataaa  atatttaaa  2340
atgctatat  tagtatatg  catagttta  aaagaatat  aacctttct  aactaaatt  2400
aggtttgca  aaagtatta  acattttta  gctgaatgt  gagacagtg  atccatttt  2460
tttagttga  tatgtttgt  ttaattgta  agccaagct  atcagttga  tctctccag  2520
ataaataat  atctgtgtg  catacgtta  tggctttgt  tgtaatact  ccactaagt  2580
attataatt  agctgtcct  tttgcatca  atgtaaaga  tgtgttcac  accgtagta  2640
aatttggtt  cattggaaa  gaaacaaat  ctaaagtat  ctttttcac  agtcccttt  2700
attttgcta  atcataacc  cttggttca  atgctgaga  atttttcag  aagtccatt  2760
ttgtttaaa  ttagaactt  tcagaatgc  aaatgaagg  taaaatttt  gccagaaca  2820
tacaaaagt  ttaaatcgt  gacgtaact  cccctgaaa  aaagttagg  agtaaaatc  2880
ttaatgaaa  cagtggatg  gcttaacgt  aggttagta  agcatacaa  gaatctagt  2940
tgctcaggg  ttggtacaa  gagctgaat  agatggcct  atgaaactc  ttctaacct  3000
ttacccaac  tgtttctcc  tggttaaaa  tatacttga  ggcccagaa  actcatggc  3060
catttgttt  atattgctt  tagttagtt  aaggtaatt  tgcttctac  gtattttgg  3120
aggtctgaa  acttgcaca  ggtcatctt  gtaattata  aaccccaaa  taagatgca  3180
aatgtctcc  tcaggtgat  acacacagt  gacgagtat  tgcaaacat  gacataata  3240
ttcacttac  aatgtgatt  gatgttaac  ctagagaat  atgactgta  aacatttga  3300
caagtaaaa  agtaaagca  atagtgagt  tatgtccgt  taactggta  attgataat  3360
tagtttggg  acataaaag  aatatttat  tggcttccc  aatgcagag  tacatctta  3420
tcgtgtatt  ctctgagta  ttatatccc  tctcctttt  tcattctta  aaataaatg  3480
attttcact  ttggcacat  tgaggctta  atataagga  cataacact  gcattctaa  3540
ttttgcata  attgtaaat  tgtctggta  ttacagcaa  atactgtgt  tccttttat  3600
ggtaaaaca  aagtgaaca  tgcatgcat  taatgtgat  aatttgtaa  ttaggagtt  3660
tttggggct  ctgtgactt  ggaaatgct  acattcagg  cttaatgtt  cattagcta  3720
catgttttc  ctctgatgt  tatagtcac  gttgtataa  ctaatcttt  cttgttttc  3780
actctgtga  ctttccata  catatttca  taatgatca  ttagtgtca  ggagtcaaa  3840
cagattaaa  ttaatttca  gtgtatatg  tggaaattt  tggctagtg  gatttttgt  3900
tgtttcctt  taagtactg  tgatcagtt  tgacactta  tggttaaac  tacgttgct  3960
aagatttct  tataataag  cacacatta  atttagact  tattaaggg  ccttggttt  4020
cttctagat  gcagctgtc  caaagaaaa  atttcttct  tgtctgtta  gatttagct  4080
ttatctgcc  gttgttaag  ggttttggt  ccaaactca  ccagcaatg  tgagagctg  4140
acttaagat  gctgttgta  tttttgctt  ccatctgtt  ctgtccttc  ttcttggct  4200
cctactatc  ataaacagc  gctgtgaag  agaaaagtt  aataagagt  ggcttaaat  4260
ttaaaaaag  aaaagaaaa  tgaggtttt  ggattttca  ggtaacaag  tctggtata  4320
gctaaggct  gcaagttca  atactaaaa  attatttga  catatcttg  atccttttg  4380
aaaagttaa  actatatga  ggtaaatta  aaataagta  gaatattaa  aaaatagca  4440
ttatcttat  tctctattt  atgttgtga  ttaacctaa  tttattttt  taacatttt  4500
ttatttctt  taatatgaa  gctgatatt  aaaggtaga  ctatgtggt  ttctttgtg  4560
ttcttaatt  tttaactct  aagattatt  gtgatctgg  tttatgtat  tgttagata  4620
atacgaatt  ttaaaatgg  atgcaagtt  ttcaaaagc  caggtctaa  tgtaatggt  4680
ggtttattg  tctataacc  cagcccatc  ttttctgtg  aaatcataa  caataaaca  4740
aatatactc  gtggtcatt  ctaat  4765



<210> 2008
<211> 708
<212> PRT
<213> Homo sapiens
<308> XP_003693
<400> 2008

Met Ser Gln Tyr Thr Glu Lys Glu Pro Ala Ala Met Asp Gln Glu Ser 
  1               5                  10                  15
Gly Lys Ala Val Trp Pro Lys Pro Ala Gly Gly Tyr Gln Thr Ile Thr 
             20                  25                  30
Gly Arg Arg Tyr Gly Arg Arg His Ala Tyr Val Ser Phe Lys Pro Cys 
         35                  40                  45
Met Thr Arg His Glu Arg Ser Leu Gly Arg Ala Gly Asp Asp Tyr Glu 
     50                  55                  60
Val Leu Glu Leu Asp Asp Val Pro Lys Glu Asn Ser Ser Gly Ser Ser 
 65                  70                  75                  80
Pro Leu Asp Gln Val Asp Ser Ser Leu Pro Ser Glu Pro Ile Phe Glu 
                 85                  90                  95
Lys Ser Glu Thr Glu Ile Pro Thr Cys Gly Ser Ala Leu Asn Gln Thr 
             100                105                110
Thr Glu Ser Ser Gln Ser Phe Val Ala Val His His Ser Glu Glu Gly 
         115                120                125
Arg Asp Thr Leu Gly Ser Ser Thr Asn Leu His Asn His Ser Glu Gly 
     130                135                140
Glu Tyr Ile Pro Gly Ala Cys Ser Ala Ser Ser Val Gln Asn Gly Ile 
 145                150                155                160
Ala Leu Val His Thr Asp Ser Tyr Asp Pro Asp Gly Lys His Gly Glu 
                 165                170                175
Asp Asn Asp His Leu Gln Leu Ser Ala Glu Val Val Glu Gly Ser Arg 
             180                185                190
Tyr Gln Glu Ser Leu Gly Asn Thr Val Phe Glu Leu Glu Asn Arg Glu 
         195                200                205
Ala Glu Ala Tyr Thr Gly Leu Ser Pro Pro Val Pro Ser Phe Asn Cys 
     210                215                220
Glu Val Arg Asp Glu Phe Glu Glu Leu Asp Ser Val Pro Leu Val Lys 
 225                230                235                240
Ser Ser Ala Gly Asp Thr Glu Phe Val His Gln Asn Ser Gln Glu Ile 
                 245                250                255
Gln Arg Ser Ser Gln Asp Glu Met Val Ser Thr Lys Gln Gln Asn Asn 
             260                265                270
Thr Ser Gln Glu Arg Gln Thr Glu His Ser Pro Glu Asp Ala Ala Cys 
         275                280                285
Gly Pro Gly His Ile Cys Ser Glu Gln Asn Thr Asn Asp Arg Glu Lys 
     290                295                300
Asn His Gly Ser Ser Pro Glu Gln Val Val Arg Pro Lys Val Arg Lys 
 305                310                315                320
Leu Ile Ser Ser Ser Gln Val Asp Gln Glu Thr Gly Phe Asn Arg His 
                 325                330                335
Glu Ala Lys Gln Arg Ser Val Gln Arg Trp Arg Glu Ala Leu Glu Val 
             340                345                350
Glu Glu Ser Gly Ser Asp Asp Leu Leu Ile Lys Cys Glu Glu Tyr Asp 
         355                360                365
Gly Glu His Asp Cys Met Phe Leu Asp Pro Pro Tyr Ser Arg Val Ile 
     370                375                380
Thr Gln Arg Glu Thr Glu Asn Asn Gln Met Thr Ser Glu Ser Gly Ala 
 385                390                395                400
Thr Ala Gly Arg Gln Glu Val Asp Asn Thr Phe Trp Asn Gly Cys Gly 
                 405                410                415
Asp Tyr Tyr Gln Leu Tyr Asp Lys Asp Glu Asp Ser Ser Glu Cys Ser 
             420                425                430
Asp Gly Glu Trp Ser Ala Ser Leu Pro His Arg Phe Ser Gly Thr Glu 
         435                440                445
Lys Asp Gln Ser Ser Ser Asp Glu Ser Trp Glu Thr Leu Pro Gly Lys 
     450                455                460
Asp Glu Asn Glu Pro Glu Leu Gln Ser Asp Ser Ser Gly Pro Glu Glu 
 465                470                475                480
Glu Asn Gln Glu Leu Ser Leu Gln Glu Gly Glu Gln Thr Ser Leu Glu 
                 485                490                495
Glu Gly Glu Ile Pro Trp Leu Gln Tyr Asn Glu Val Asn Glu Ser Ser 
             500                505                510
Ser Asp Glu Gly Asn Glu Pro Ala Asn Glu Phe Ala Gln Pro Ala Phe 
         515                520                525
Met Leu Asp Gly Asn Asn Asn Leu Glu Asp Asp Ser Ser Val Ser Glu 
     530                535                540
Asp Leu Asp Val Asp Trp Ser Leu Phe Asp Gly Phe Ala Asp Gly Leu 
 545                550                555                560
Gly Val Ala Glu Ala Ile Ser Tyr Val Asp Pro Gln Phe Leu Thr Tyr 
                 565                570                575
Met Ala Leu Glu Glu Arg Leu Ala Gln Ala Met Glu Thr Ala Leu Ala 
             580                585                590
His Leu Glu Ser Leu Ala Val Asp Val Glu Val Ala Asn Pro Pro Ala 
         595                600                605
Ser Lys Glu Ser Ile Asp Gly Leu Pro Glu Thr Leu Val Leu Glu Asp 
     610                615                620
His Thr Ala Ile Gly Gln Glu Gln Cys Cys Pro Ile Cys Cys Ser Glu 
 625                630                635                640
Tyr Ile Lys Asp Asp Ile Ala Thr Glu Leu Pro Cys His His Phe Phe 
                 645                650                655
His Lys Pro Cys Val Ser Ile Trp Leu Gln Lys Ser Gly Thr Cys Pro 
             660                665                670
Val Cys Arg Arg His Phe Pro Pro Ala Val Ile Glu Ala Ser Ala Ala 
         675                680                685
Pro Ser Ser Glu Pro Asp Pro Asp Ala Pro Pro Ser Asn Asp Ser Ile 
     690                695                700
Thr Glu Ala Pro 
 705



<210> 2009
<211> 3726
<212> DNA
<213> Rattus norvegicus
<308> D37880
<400> 2009

ccggcatgg  gcggcgtcg  cgccgatgg  gctgaggcg  agcatgggg  ggccggggc  60
ccggccgct  ctgctggcg  ggctggcct  tctgctgct  ccagggtcc  cggccgcag  120
cctgaagct  atgggagcc  cagtgaaga  gacagtgtc  caggggcag  cagtgaagc  180
taactgcag  gtggaaggg  tggatgacc  tgacataca  tggatgaag  atggcgctg  240
ggtccagaa  gcaagccag  tgtccatct  aataagcga  cagaactgg  ttggcttac  300
cagcctaaa  tcagcggag  ggtctgatg  cggcctgta  tggtgccag  tgaaggatg  360
ggaggaaac  aagatctct  agtcagtat  gctcactgt  gaaggtgtg  cattcttca  420
ggtggaacc  aaagatctg  cggtgccac  caatgtccc  tttcaactg  cttgtgagg  480
tgtgggtcc  ccagaaccc  taaccattt  ctggtggag  ggacccact  aggttgggg  540
acctgcttc  tctccctct  ttttaaatg  aacaggagt  acccagcgc  cagagtttt  600
ttgtgaagc  cataacata  aaggcctgg  cacttcccg  ccagccatt  ttcgccttc  660
agcaccgcc  gcagctcct  tcaacatca  agtaacaac  atctccagc  gcaacgcta  720
tgtggcctg  gtgccgggt  ctgatggct  agctctgct  cactcctgt  ctgtacagg  780
ggcacatgc  ccaggagaa  gggaggccc  tgctgtcgt  gttcccgtg  cacccttta  840
ttgcttgct  cggaacttg  cccctgcca  caactacag  cttagggtt  gctgtgcca  900
cgccttggg  ccttctccc  atggcgact  ggtgccctt  cagacaaag  gcctagcgc  960
agccagagc  cctcagaat  tccacgcca  tcgtactga  tcaggcctt  tcctggaat  1020
ggaagaagt  attcctgag  accctgggg  aggccccct  ggaccttat  agctgtcct  1080
ggtccaaga  aatggaacc  aggatgagc  gatggtgga  ggaactacg  ccaatctga  1140
tgactggga  ccccagaag  acctggttt  gcgtgtgtg  gcctccaat  caattggtg  1200
tgggccctg  agtcaacca  tggtggtgt  ttctcatga  catgcaggg  ggcagggcc  1260
tcctcacag  cgtacatcc  gggtgcctg  ggtcctggg  gtgctcacc  ccctgatca  1320
agctgctgc  ttggccctc  tcctgcttc  gaagagacg  aaggagacg  ggttcgggc  1380
agcctttga  agtgtcatg  cccgagggg  gccagctgt  cacttccgg  cagcccggt  1440
tttcaatcg  gaaaggcct  aacgcattg  agctacatt  gatagcctg  gcatcagcg  1500
tgaattgaa  gagaagctg  aggacgtcc  catcccaga  cagcagttc  ccctcggcc  1560
gatgttggg  aaaggagag  ttggatcag  gcgggaagc  cagctgaag  aggaagatg  1620
ctcctttgt  aaagtggca  tgaagatgc  gaaagctga  atcattgcc  caagcgaca  1680
agaagagtt  ctgagagaa  cagcttgca  gaaggagtt  gaccatcca  acgtggcca  1740
gcttgttgg  gtgagcctc  ggagcaggg  taaaggtcg  ctccccatt  ccatggtca  1800
cctgccctt  atgaagcac  gagacttgc  tgcctttct  ctcgcctcc  gaattgggg  1860
gaacccttt  aacctgccc  tccagaccc  cgtccggtt  atggtggac  ttgcctgtg  1920
catggagta  ctgagctcc  ggaacttca  ccaccgaga  ctagcagct  ggaattgca  1980
gctggcaga  gacatgaca  tgtgtgtgg  tgactttgg  ctctcccgg  aaatttata  2040
cggggacta  tatcgtcag  gctgtgcct  caaactgcc  gtcaagtgg  tggccctgg  2100
gagcttggc  gacaacttg  atactgtac  cagcgatgt  tgggccttc  gggtgacca  2160
gtgggagat  atgactcgt  ggcagacgc  atatgctgg  atcgaaaat  ctgagattt  2220
caactacct  atcagcggg  accgcctga  gcagcctcc  gagtgcatg  aggaagtgt  2280
tgatctcat  taccagtgc  ggagtgccg  cccaaagca  cgcccaagc  tcacatgcc  2340
gcgaatgga  ctggagaac  ttctgggcc  cctatctgt  ctgtccacc  gccaggacc  2400
cttgtacat  aacattgag  gagctgggc  gcctgctga  aatggcagt  ccgagctgc  2460
ctgtggaga  cagtctagc  gcgaggcgg  ggatggcag  ggcatgggg  caataggtg  2520
catccccag  gactgtcgg  acatcttca  ccctggagg  ttggccgag  caccagggc  2580
gctggagca  cagccagaa  gccccctca  cgagaacca  aggcttttg  tgttgcagc  2640
agggctact  cctcacagt  gctgttaac  tgcaggcag  ggacagctg  ggccccctg  2700
ctctgccgg  cattgcgct  gcttactag  ccccgtctg  tcacagccc  ggcagcaag  2760
tatggaggc  cctgtggta  tcctcccaa  ctgtgctgg  acctggact  accaaattg  2820
ccaatccca  ttcttcctg  agccgctct  gccagcctg  catcagttc  ggccttggc  2880
tagaggagg  gagccagat  tggttgcct  aatgcaggc  gctggcagg  ggggagggt  2940
gctgtgttt  catgggtac  atgggtgtg  atggcagta  gggagggta  cagcagccc  3000
gtgggcccc  accctcctg  ctgagctgc  cctacttta  tgcatgctt  gagccgcct  3060
cagcctgga  ctcagcact  cccaccaca  ctgagttta  atgccaggt  tgcccctct  3120
cgtcacaaa  agatgtcct  gtattgttc  cttttaggt  acgattagg  agggattgg  3180
acacttagg  ccttaagcc  catgacagg  aatggtggg  tattctcag  tccgaatcc  3240
catcacctt  ctgattccc  accctgcca  ggcctggaa  tgactgggt  gctgaggga  3300
gcacgagga  aaagactac  gagatccga  tcctaaagg  agggtctga  tctgccaga  3360
ggagggggt  ctaagaggt  ggcccagga  tcaggcatt  caggacccc  ctaagcttc  3420
acagtctgt  tgagcatgc  accaagccc  caaacatcc  agaactaac  ggcagtttt  3480
tctgagccc  gcccttcca  atggtgacc  ttaggtcta  catcctctc  gaatggata  3540
cacttgtcc  aagtcttaa  agagagata  acctgatgg  tgatgtggg  aagaaaagt  3600
cctggaacc  gggctgggg  ctaggcacc  cactgcaaa  ctcctggaa  gcagaggca  3660
gctcttggg  tgttaggaa  atttccaag  tattaagtt  ctgtttcaa  acaataaaa  3720
tgaaac  3726



<210> 2010
<211> 880
<212> PRT
<213> Rattus norvegicus
<308> P55146
<400> 2010

Met Ala Leu Arg Arg Ser Met Gly Arg Pro Gly Leu Arg Pro Leu Leu 
  1               5                  10                  15
Leu Ala Gly Leu Ala Ser Leu Leu Leu Pro Gly Ser Ala Ala Ala Gly 
             20                  25                  30
Leu Lys Leu Met Gly Ala Pro Val Lys Met Thr Val Ser Gln Gly Gln 
         35                  40                  45
Pro Val Lys Leu Asn Cys Ser Val Glu Gly Met Asp Asp Pro Asp Ile 
     50                  55                  60
His Trp Met Lys Asp Gly Ala Val Val Gln Asn Ala Ser Gln Val Ser 
 65                  70                  75                  80
Ile Ser Ile Ser Glu Gln Asn Trp Ile Gly Leu Leu Ser Leu Lys Ser 
                 85                  90                  95
Ala Glu Arg Ser Asp Ala Gly Leu Tyr Trp Cys Gln Val Lys Asp Gly 
             100                105                110
Glu Glu Thr Lys Ile Ser Gln Ser Val Trp Leu Thr Val Glu Gly Val 
         115                120                125
Pro Phe Phe Thr Val Glu Pro Lys Asp Leu Ala Val Pro Pro Asn Val 
     130                135                140
Pro Phe Gln Leu Ser Cys Glu Ala Val Gly Pro Pro Glu Pro Val Thr 
 145                150                155                160
Ile Phe Trp Trp Arg Gly Pro Thr Lys Val Gly Gly Pro Ala Ser Ser 
                 165                170                175
Pro Ser Val Leu Asn Val Thr Gly Val Thr Gln Arg Thr Glu Phe Ser 
             180                185                190
Cys Glu Ala His Asn Ile Lys Gly Leu Ala Thr Ser Arg Pro Ala Ile 
         195                200                205
Ile Arg Leu Gln Ala Pro Pro Ala Ala Pro Phe Asn Ile Thr Val Thr 
     210                215                220
Thr Ile Ser Ser Ser Asn Ala Ser Val Ala Trp Val Pro Gly Ala Asp 
 225                230                235                240
Gly Leu Ala Leu Leu His Ser Cys Thr Val Gln Val Ala His Ala Pro 
                 245                250                255
Gly Glu Trp Glu Ala Leu Ala Val Val Val Pro Val Pro Pro Phe Thr 
             260                265                270
Cys Leu Leu Arg Asn Leu Ala Pro Ala Thr Asn Tyr Ser Leu Arg Val 
         275                280                285
Arg Cys Ala Asn Ala Leu Gly Pro Ser Pro Tyr Gly Asp Trp Val Pro 
     290                295                300
Phe Gln Thr Lys Gly Leu Ala Pro Ala Arg Ala Pro Gln Asn Phe His 
 305                310                315                320
Ala Ile Arg Thr Asp Ser Gly Leu Ile Leu Glu Trp Glu Glu Val Ile 
                 325                330                335
Pro Glu Asp Pro Gly Glu Gly Pro Leu Gly Pro Tyr Lys Leu Ser Trp 
             340                345                350
Val Gln Glu Asn Gly Thr Gln Asp Glu Leu Met Val Glu Gly Thr Thr 
         355                360                365
Ala Asn Leu Thr Asp Trp Asp Pro Gln Lys Asp Leu Val Leu Arg Val 
     370                375                380
Cys Ala Ser Asn Ala Ile Gly Asp Gly Pro Trp Ser Gln Pro Leu Val 
 385                390                395                400
Val Ser Ser His Asp His Ala Gly Arg Gln Gly Pro Pro His Ser Arg 
                 405                410                415
Thr Ser Trp Val Pro Val Val Leu Gly Val Leu Thr Ala Leu Ile Thr 
             420                425                430
Ala Ala Ala Leu Ala Leu Ile Leu Leu Arg Lys Arg Arg Lys Glu Thr 
         435                440                445
Arg Phe Gly Gln Ala Phe Asp Ser Val Met Ala Arg Gly Glu Pro Ala 
     450                455                460
Val His Phe Arg Ala Ala Arg Ser Phe Asn Arg Glu Arg Pro Glu Arg 
 465                470                475                480
Ile Glu Ala Thr Leu Asp Ser Leu Gly Ile Ser Asp Glu Leu Lys Glu 
                 485                490                495
Lys Leu Glu Asp Val Leu Ile Pro Glu Gln Gln Phe Thr Leu Gly Arg 
             500                505                510
Met Leu Gly Lys Gly Glu Phe Gly Ser Val Arg Glu Ala Gln Leu Lys 
         515                520                525
Gln Glu Asp Gly Ser Phe Val Lys Val Ala Val Lys Met Leu Lys Ala 
     530                535                540
Asp Ile Ile Ala Ser Ser Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala 
 545                550                555                560
Cys Met Lys Glu Phe Asp His Pro His Val Ala Lys Leu Val Gly Val 
                 565                570                575
Ser Leu Arg Ser Arg Ala Lys Gly Arg Leu Pro Ile Pro Met Val Ile 
             580                585                590
Leu Pro Phe Met Lys His Gly Asp Leu His Ala Phe Leu Leu Ala Ser 
         595                600                605
Arg Ile Gly Glu Asn Pro Phe Asn Leu Pro Leu Gln Thr Leu Val Arg 
     610                615                620
Phe Met Val Asp Ile Ala Cys Gly Met Glu Tyr Leu Ser Ser Arg Asn 
 625                630                635                640
Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Ala Glu Asp 
                 645                650                655
Met Thr Val Cys Val Ala Asp Phe Gly Leu Ser Arg Lys Ile Tyr Ser 
             660                665                670
Gly Asp Tyr Tyr Arg Gln Gly Cys Ala Ser Lys Leu Pro Val Lys Trp 
         675                680                685
Leu Ala Leu Glu Ser Leu Ala Asp Asn Leu Tyr Thr Val His Ser Asp 
     690                695                700
Val Trp Ala Phe Gly Val Thr Met Trp Glu Ile Met Thr Arg Gly Gln 
 705                710                715                720
Thr Pro Tyr Ala Gly Ile Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile 
                 725                730                735
Ser Gly Asn Arg Leu Lys Gln Pro Pro Glu Cys Met Glu Glu Val Tyr 
             740                745                750
Asp Leu Met Tyr Gln Cys Trp Ser Ala Asp Pro Lys Gln Arg Pro Ser 
         755                760                765
Phe Thr Cys Leu Arg Met Glu Leu Glu Asn Ile Leu Gly His Leu Ser 
     770                775                780
Val Leu Ser Thr Ser Gln Asp Pro Leu Tyr Ile Asn Ile Glu Arg Ala 
 785                790                795                800
Gly Gln Pro Ala Glu Asn Gly Ser Pro Glu Leu Pro Cys Gly Glu Gln 
                 805                810                815
Ser Ser Ser Glu Ala Gly Asp Gly Ser Gly Met Gly Ala Ile Gly Gly 
             820                825                830
Ile Pro Ser Asp Cys Arg Tyr Ile Phe Ser Pro Gly Gly Leu Ala Glu 
         835                840                845
Ser Pro Gly Gln Leu Glu Gln Gln Pro Glu Ser Pro Leu Asn Glu Asn 
     850                855                860
Gln Arg Leu Leu Leu Leu Gln Gln Gly Leu Leu Pro His Ser Ser Cys 
 865                870                875                880



<210> 2011
<211> 3031
<212> DNA
<213> Homo sapiens
<308> U02566
<400> 2011

cctctccat  tgttttaaa  gtaacaggg  tgacccaga  caccatgtt  tcctgtgaa  60
ctcacaacc  aaaaggcct  gcctcttct  gcacagcca  tgttcacct  caagcactg  120
ctgcagccc  cttcaacat  accgtgaca  agctttcca  cagcaacgc  agtgtggcc  180
ggatgccag  tgctgatgg  cgagctctg  tacagtcct  tacagttca  gtgacacag  240
ccccaggag  ctgggaagt  ctggctgtt  tggtccctg  gcccccctt  acctgcctg  300
tccgggacc  ggtgcctgc  accaactac  gcctcaggg  gcgctgtgc  aatgccttg  360
ggccctctc  ctatgctga  tgggtgccc  ttcagacca  gggtctagc  ccagccagc  420
ctccccaaa  cctccatgc  atccgcaca  attcaggcc  catcttgga  tgggaagaa  480
tgatccccg  ggccccttt  gaaggcccc  tgggaccct  caaactgtc  tgggttcaa  540
acaatggaa  ccaggatga  ctgacagtg  aggggacca  ggccaattt  acaggctgg  600
atccccaaa  ggacctgat  gtacgtgtg  gcgtctcca  tgcagttgg  tgtggaccc  660
ggagtcagc  actggtggt  tcttctcat  accgtgcag  ccagcaggg  cctcctcac  720
gccgcacat  ctgggtacc  gtggtcctt  gtgtgctaa  ggccctggt  acggctgct  780
ccctggccc  catcctgct  cgaaagaga  ggaaagaga  gcggtttgg  caagccttt  840
acagtgtca  ggcccgggg  gagccagcc  ttcacttcc  ggcagcccg  tccttcaat  900
gagaaaggc  cgagcgcat  gaggccaca  tggacagct  gggcatcag  gatgaacta  960
aggaaaaac  ggaggatgt  ctcatccca  agcagcagt  caccctggg  cggatgttg  1020
gcaaaggag  gtttggttc  gtgcgggag  cccagctga  gcaagagga  ggctccttt  1080
tgaaagtgg  tgtgaagat  ctgaaagct  acatcattg  ctcaagcga  attgaagag  1140
tcctcaggg  agcagcttg  atgaaggag  ttgaccatc  acacgtggc  aaacttgtt  1200
gggtaagcc  ccggagcag  gctaaaggc  gtctcccca  ccccatggt  atcttgccc  1260
tcatgaagc  tggggacct  catgccttc  tgctcgcct  ccggattgg  gagaacccc  1320
ttaacctac  cctccagac  ctgatccgg  tcatggtgg  cacttgcgg  atggagtac  1380
tgagctctc  gaacttcat  caccgagac  tggctgctc  gaattgcat  ctggcagag  1440
acatgacag  gtgtgtggc  gacttcgga  tctcccgga  gatctacag  ggggactac  1500
atcgtcaag  ctgtgcctc  aaactgcct  tcaagtggc  ggccctgga  agcctggcc  1560
acaacctgt  tactgtgca  agtgacgtg  gggcgttcg  ggtgaccat  tgggagatc  1620
tgacacgtg  gcagacgcc  tatgctggc  tcgaaaacg  tgagattta  aactacctc  1680
ttggcggga  cctgaaaca  cctccggag  gtatggagg  cgtgtatga  ctcatgtac  1740
agtgctgga  tgctgaccc  aagcagcgc  cgagcttta  ttgtctgcg  atggaactg  1800
agaacatct  gggccagct  tctgtgcta  ctgccagcc  ggacccctt  tacatcaac  1860
tcgagagag  tgaggagcc  actgcggga  gcagcctgg  gctacctgg  agggatcag  1920
cctacagtg  ggctgggga  ggcagtggc  tgggggcag  gggtggcac  cccagtgac  1980
gtcggtaca  actcacccc  ggagggctg  ctgagcagc  agggcaggc  gagcaccag  2040
cagagagtc  cctcaatga  acacagagg  ttttgctgc  gcagcaagg  ctactgcac  2100
cagtagctg  tagcccaca  gagagggca  cggggccat  tgcggctct  gtggccact  2160
agctggctg  ctaagcccc  tctgacccc  gcccagaca  caaggtgtg  aggctcctg  2220
ggtagtcct  ccaagctgt  ctgggaagc  cggactgac  aaatcaccc  atcccagtt  2280
ttcctgcaa  cactctgtg  cagcctggc  tcagtttag  ccttggctt  attggaagt  2340
ggccagtcc  ggttgtctg  acccaggca  ctggcagga  tggggtggt  atgtttcta  2400
gttacatgg  gtggatggc  gtgtgggag  gcaggtcag  tctgtggcc  acctctcct  2460
ctgagctgc  cctgctgct  aagtgcatg  attgagctg  ctccagcct  gtggcccag  2520
tattaccac  cttggggtt  aaatattcc  ggtgtgccc  tccaagtca  aaagagatg  2580
ccttgtaat  ttccctttt  ggtgagggt  ggtaagggg  tggtatctc  ggtctgaat  2640
ttcaaccat  tttctgatt  cgcaccctg  ctacgccag  agaagttga  gggagcatg  2700
ttccctgca  ctgaccggg  cacacaaag  catgctgga  tacccagcc  atcaggtgc  2760
cctcttcca  aggcagcgt  ccgagccag  aagaggaag  ggtgctgtg  ggcttgccc  2820
ggagcaagt  aggccggag  ggagttcag  aacccttct  catacccac  atctgagca  2880
gctaccaaa  ctcaaaata  cctaagact  acaaaggca  ctgtgtctg  gcccaaccc  2940
tctaaacgg  gacctttag  gccaacttc  cctctaact  gacagcctc  tctgtccca  3000
gtctccaga  agaaatcag  cctgatgag  g  3031



<210> 2012
<211> 890
<212> PRT
<213> Homo sapiens
<308> Q06418
<400> 2012

Met Ala Leu Arg Arg Ser Met Gly Arg Pro Gly Leu Pro Pro Leu Pro 
  1               5                  10                  15
Leu Pro Pro Pro Pro Arg Leu Gly Leu Leu Leu Ala Ala Leu Ala Ser 
             20                  25                  30
Leu Leu Leu Pro Glu Ser Ala Ala Ala Gly Leu Lys Leu Met Gly Ala 
         35                  40                  45
Pro Val Lys Leu Thr Val Ser Gln Gly Gln Pro Val Lys Leu Asn Cys 
     50                  55                  60
Ser Val Glu Gly Met Glu Glu Pro Asp Ile Gln Trp Val Lys Asp Gly 
 65                  70                  75                  80
Ala Val Val Gln Asn Leu Asp Gln Leu Tyr Ile Pro Val Ser Glu Gln 
                 85                  90                  95
His Trp Ile Gly Phe Leu Ser Leu Lys Ser Val Glu Arg Ser Asp Ala 
             100                105                110
Gly Arg Tyr Trp Cys Gln Val Glu Asp Gly Gly Glu Thr Glu Ile Ser 
         115                120                125
Gln Pro Val Trp Leu Thr Val Glu Gly Val Pro Phe Phe Thr Val Glu 
     130                135                140
Pro Lys Asp Leu Ala Val Pro Pro Asn Ala Pro Phe Gln Leu Ser Cys 
 145                150                155                160
Glu Ala Val Gly Pro Pro Glu Pro Val Thr Ile Val Trp Trp Arg Gly 
                 165                170                175
Thr Thr Lys Ile Gly Gly Pro Ala Pro Ser Pro Ser Val Leu Asn Val 
             180                185                190
Thr Gly Val Thr Gln Ser Thr Met Phe Ser Cys Glu Ala His Asn Leu 
         195                200                205
Lys Gly Leu Ala Ser Ser Arg Thr Ala Thr Val His Leu Gln Ala Leu 
     210                215                220
Pro Ala Ala Pro Phe Asn Ile Thr Val Thr Lys Leu Ser Ser Ser Asn 
 225                230                235                240
Ala Ser Val Ala Trp Met Pro Gly Ala Asp Gly Arg Ala Leu Leu Gln 
                 245                250                255
Ser Cys Thr Val Gln Val Thr Gln Ala Pro Gly Gly Trp Glu Val Leu 
             260                265                270
Ala Val Val Val Pro Val Pro Pro Phe Thr Cys Leu Leu Arg Asp Leu 
         275                280                285
Val Pro Ala Thr Asn Tyr Ser Leu Arg Val Arg Cys Ala Asn Ala Leu 
     290                295                300
Gly Pro Ser Pro Tyr Ala Asp Trp Val Pro Phe Gln Thr Lys Gly Leu 
 305                310                315                320
Ala Pro Ala Ser Ala Pro Gln Asn Leu His Ala Ile Arg Thr Asp Ser 
                 325                330                335
Gly Leu Ile Leu Glu Trp Glu Glu Val Ile Pro Glu Ala Pro Leu Glu 
             340                345                350
Gly Pro Leu Gly Pro Tyr Lys Leu Ser Trp Val Gln Asp Asn Gly Thr 
         355                360                365
Gln Asp Glu Leu Thr Val Glu Gly Thr Arg Ala Asn Leu Thr Gly Trp 
     370                375                380
Asp Pro Gln Lys Asp Leu Ile Val Arg Val Cys Val Ser Asn Ala Val 
 385                390                395                400
Gly Cys Gly Pro Trp Ser Gln Pro Leu Val Val Ser Ser His Asp Arg 
                 405                410                415
Ala Gly Gln Gln Gly Pro Pro His Ser Arg Thr Ser Trp Val Pro Val 
             420                425                430
Val Leu Gly Val Leu Thr Ala Leu Val Thr Ala Ala Ala Leu Ala Leu 
         435                440                445
Ile Leu Leu Arg Lys Arg Arg Lys Glu Thr Arg Phe Gly Gln Ala Phe 
     450                455                460
Asp Ser Val Met Ala Arg Gly Glu Pro Ala Val His Phe Arg Ala Ala 
 465                470                475                480
Arg Ser Phe Asn Arg Glu Arg Pro Glu Arg Ile Glu Ala Thr Leu Asp 
                 485                490                495
Ser Leu Gly Ile Ser Asp Glu Leu Lys Glu Lys Leu Glu Asp Val Leu 
             500                505                510
Ile Pro Glu Gln Gln Phe Thr Leu Gly Arg Met Leu Gly Lys Gly Glu 
         515                520                525
Phe Gly Ser Val Arg Glu Ala Gln Leu Lys Gln Glu Asp Gly Ser Phe 
     530                535                540
Val Lys Val Ala Val Lys Met Leu Lys Ala Asp Ile Ile Ala Ser Ser 
 545                550                555                560
Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala Cys Met Lys Glu Phe Asp 
                 565                570                575
His Pro His Val Ala Lys Leu Val Gly Val Ser Leu Arg Ser Arg Ala 
             580                585                590
Lys Gly Arg Leu Pro Ile Pro Met Val Ile Leu Pro Phe Met Lys His 
         595                600                605
Gly Asp Leu His Ala Phe Leu Leu Ala Ser Arg Ile Gly Glu Asn Pro 
     610                615                620
Phe Asn Leu Pro Leu Gln Thr Leu Ile Arg Phe Met Val Asp Ile Ala 
 625                630                635                640
Cys Gly Met Glu Tyr Leu Ser Ser Arg Asn Phe Ile His Arg Asp Leu 
                 645                650                655
Ala Ala Arg Asn Cys Met Leu Ala Glu Asp Met Thr Val Cys Val Ala 
             660                665                670
Asp Phe Gly Leu Ser Arg Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln 
         675                680                685
Gly Cys Ala Ser Lys Leu Pro Val Lys Trp Leu Ala Leu Glu Ser Leu 
     690                695                700
Ala Asp Asn Leu Tyr Thr Val Gln Ser Asp Val Trp Ala Phe Gly Val 
 705                710                715                720
Thr Met Trp Glu Ile Met Thr Arg Gly Gln Thr Pro Tyr Ala Gly Ile 
                 725                730                735
Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile Gly Gly Asn Arg Leu Lys 
             740                745                750
Gln Pro Pro Glu Cys Met Glu Asp Val Tyr Asp Leu Met Tyr Gln Cys 
         755                760                765
Trp Ser Ala Asp Pro Lys Gln Arg Pro Ser Phe Thr Cys Leu Arg Met 
     770                775                780
Glu Leu Glu Asn Ile Leu Gly Gln Leu Ser Val Leu Ser Ala Ser Gln 
 785                790                795                800
Asp Pro Leu Tyr Ile Asn Ile Glu Arg Ala Glu Glu Pro Thr Ala Gly 
                 805                810                815
Gly Ser Leu Glu Leu Pro Gly Arg Asp Gln Pro Tyr Ser Gly Ala Gly 
             820                825                830
Asp Gly Ser Gly Met Gly Ala Val Gly Gly Thr Pro Ser Asp Cys Arg 
         835                840                845
Tyr Ile Leu Thr Pro Gly Gly Leu Ala Glu Gln Pro Gly Gln Ala Glu 
     850                855                860
His Gln Pro Glu Ser Pro Leu Asn Glu Thr Gln Arg Leu Leu Leu Leu 
 865                870                875                880
Gln Gln Gly Leu Leu Pro His Ser Ser Cys 
                 885                890



<210> 2013
<211> 3477
<212> DNA
<213> Rattus norvegicus
<308> D38222
<400> 2013

cgagagctc  gagccggga  ggatgaggc  cccgcggcg  cccggaggt  ccgcgggct  60
cgggggctc  gagggttcc  ggggccttc  gctgctggt  tgcctgctg  tgttgagcg  120
cccgccccg  gggctgcag  gccatcagt  cccacggct  tctctttga  cgcagactt  180
gttcgcatc  ggaagtctg  attcaggat  gcttgtttg  acagtgcca  gcaggagtg  240
ggcaggcac  gcccctgtt  caagtcact  ccccagttc  ccagcgctt  caaggtgtg  300
tccggcaac  catgtccca  ggcttgttc  tggcatgat  acctcaccc  gtatgtgat  360
tcccaggag  tggaacgaa  ccccaggct  cgtccccca  aacctcatc  aagggacag  420
tctggatcg  tgcccagga  agcaggccc  gcaggggaa  tgctttctc  gggcaatcc  480
actggctcc  ctcctgctg  ccaggggct  tctcggcct  caggggatg  gaatggagc  540
ggggtgggc  ccccactgt  ctctctgca  gctgagctg  taccccctc  cttggagca  600
ctgctaatg  ccccgcagc  tccacaccc  tctctgacc  atgaacctg  attgctaca  660
ccttacttg  tccagcagt  tggttcccg  gatggctcc  ggggctcag  gagcgcctc  720
ggggtagtt  gccatctgg  caaggctga  gatcctgta  tcttcagca  aagcctctc  780
aaggccatt  tggggactc  ctctggaca  tcctttggt  accttacag  tccctcacc  840
gctcagctt  tccaggatt  agggctgct  tacatggcc  aagagttgc  agtgcctgg  900
agagcccgg  cgccaaggt  gccagagga  gggggcagc  gccgggcag  ggactcttc  960
gagggccat  aggaggaag  actaggggg  catggggag  agtcccctc  ccaagcagt  1020
caagcagat  taagtctgc  gagattggc  gctgtgctg  caggctacg  agtagagct  1080
cgtcagctg  ccccggaac  gctttctac  ctcttaacc  tgctgcagt  actgcccaa  1140
ggcacagga  gacatcttg  aggggctgt  aacggagga  ccgatgtca  gaaaacaat  1200
gaagaacaa  tgcagagag  ggacacagc  gacgctcgg  cccccacac  cttgcttcc  1260
ggacacccc  ctgccagct  cacctccat  aaagttcgg  aggtgctga  ccctggttt  1320
cctgaacct  ccaagacat  cagtcctct  ggcatctcg  ctgtcctgc  ggagaagaa  1380
agtcccttg  gccagagcc  gcccacagt  gtgggacag  cttcagctc  accgtccgc  1440
gaggagtat  gctatatag  cactgatca  aaacccctg  gtctggtgg  tggagtgaa  1500
ttgctggag  tcctggctg  acatgtgca  atgacttca  gcagcttca  caacatcag  1560
gtggtagga  cagctgtca  cttccgaat  cggcacaat  agcagaact  gtctttggc  1620
gatgtgacc  agcaagctg  gctggtgaa  tctgaactg  aagcgcaga  agggctcca  1680
attttgcag  caggggtgg  acagaggga  gaatccgcc  cagtccttc  ccgacaagc  1740
catcggata  ctcccatgc  ctcattgct  cttactctg  tggccctgg  aggtgtcgc  1800
gggctacta  tagctttgg  ggtggccct  tgtatgcgc  atcattcga  acaacggga  1860
aaggagcgc  tggccgcgc  ggggccgga  ggggcccac  gtgacacta  ttttgaata  1920
caggacctg  gtcgccagc  catggccac  aagtcgctg  ttaaccggg  agagggtca  1980
ccagagcct  ctcgggtga  cagtgtgtc  tcccagttc  gtgacgcgg  ccaggccag  2040
cccagttcc  acagcagca  accgtcctg  tgcgaggag  ctgcccagg  caacatgga  2100
atctccaca  gacacatga  tctggcata  atggaggat  acctccgga  ccgggaccg  2160
ttggccaag  agtggcagg  cctgtgcgc  taccaagcg  agccaaaca  ctgtgccac  2220
gcacaaggt  aaggcaaca  caagaagaa  cgccatcct  acttcttac  ctatgacca  2280
gcccgaatc  agctgaaag  ggagagcag  ccctctcgg  gtgattaca  caacgccag  2340
cccatcatc  agcatgacc  tcggatgcc  gcctacata  ccacacagg  acccctgtc  2400
cacaccatc  cagacttct  gcagatggt  tgggagagt  gctgcactg  catcgttat  2460
ctgacccct  tggtggagg  tggtgtcaa  cagtgtgac  gctactggc  ggatgaagg  2520
tcctccctc  accacgtct  tgaggtgaa  ctggtgtct  agcacatct  gtgcgagga  2580
ttcctggtg  ggagcttct  cctgaagaa  gtgcagacc  aggagacgc  cacgctcac  2640
cagttccac  tcctcagct  gccggcaga  ggcactccg  cctccaccc  gccgctgct  2700
gacttccgc  ggaaagtga  caagtgcta  agaggccgc  cctgtccca  catagtgca  2760
tgcagtgat  gtgcaggga  gacaggcac  tacatcctt  ttgacatgg  actgaatcg  2820
atggcgaaa  gagtgaagg  gattgatat  gctgccacc  tggagcatg  ccgtgacca  2880
cgacctggc  ttgtccgtt  taaggacca  tttgagttt  cgctgacag  cgtggcgga  2940
gaggtgaat  ccatcctca  ggccctgcc  cagtgagcc  cctgggtac  tcagtgggc  3000
tcctggcct  tgctccttc  gcctgtgtg  gagcatttg  gcacccact  ttcagcccc  3060
acccatctg  caccttggt  cgtccgact  gggcatgat  gccctttcc  acccagtgt  3120
gaaggaagt  gggagggaa  gggcaggtc  accctgctt  attcacgct  gaaccaaga  3180
ctcctgtgg  aaacagaca  caggcaagg  gaggagtgg  caccagcag  aagtgtgcc  3240
gagccccat  cttcctgag  ctctgtctc  ctctgtgtg  gtacctccc  actcccacc  3300
gcctatcgt  tatagacaa  gcagaatga  aaggcccca  ctcccccca  tcctgctac  3360
actggcctg  caccttgac  ctgctcaac  ttctccctc  agcacaagc  aacatttct  3420
gaaaaatct  cttttgtat  aatgtgaat  aagttagtg  gttgtctgt  cagctgc  3477



<210> 2014
<211> 923
<212> PRT
<213> Rattus norvegicus
<308> D38222
<400> 2014

Met Ala Cys Leu Asp Ser Ala Arg Gln Glu Trp Gly Arg His Gly Pro 
  1               5                  10                  15
Cys Tyr Lys Ser Leu Pro Gln Phe Ser Ser Ala Tyr Lys Val Cys Ser 
             20                  25                  30
Gly Asn Ser Cys Pro Lys Ala Cys Ser Trp His Asp Asp Leu Thr Gln 
         35                  40                  45
Tyr Val Ile Ser Gln Glu Met Glu Arg Ile Pro Arg Leu Arg Pro Pro 
     50                  55                  60
Glu Pro His Pro Arg Asp Arg Ser Gly Ser Val Pro Arg Arg Ala Gly 
 65                  70                  75                  80
Pro Ala Gly Glu Leu Leu Ser Gln Gly Asn Pro Thr Gly Ser Ser Pro 
                 85                  90                  95
Ala Val Gln Gly Leu Ser Arg Pro Pro Gly Asp Gly Asn Gly Ala Gly 
             100                105                110
Val Gly Ser Pro Leu Ser Ser Leu Gln Ala Glu Leu Leu Pro Pro Leu 
         115                120                125
Leu Glu His Leu Leu Met Pro Pro Gln Pro Pro His Pro Ser Leu Thr 
     130                135                140
Tyr Glu Pro Ala Leu Leu Gln Pro Tyr Leu Phe Gln Gln Phe Gly Ser 
 145                150                155                160
Arg Asp Gly Ser Arg Gly Ser Glu Ser Ala Ser Gly Val Val Gly His 
                 165                170                175
Leu Ala Lys Ala Glu Asp Pro Val Leu Phe Ser Arg Ser Leu Ser Lys 
             180                185                190
Ala Ile Leu Gly Thr His Ser Gly His Ser Phe Gly Asp Leu Thr Gly 
         195                200                205
Pro Ser Pro Ala Gln Leu Phe Gln Asp Ser Gly Leu Leu Tyr Met Ala 
     210                215                220
Gln Glu Leu Pro Val Pro Gly Arg Ala Arg Ala Pro Arg Leu Pro Glu 
 225                230                235                240
Glu Gly Gly Ser Ser Arg Ala Glu Asp Ser Ser Glu Gly His Glu Glu 
                 245                250                255
Glu Val Leu Gly Gly His Gly Glu Lys Ser Pro Pro Gln Ala Val Gln 
             260                265                270
Ala Asp Val Ser Leu Gln Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly 
         275                280                285
Val Glu Leu Arg Gln Leu Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr 
     290                295                300
Leu Leu Gln Leu Leu Pro Lys Gly Thr Gly Arg His Leu Gly Gly Ala 
 305                310                315                320
Val Asn Gly Gly Ala Asp Val Lys Lys Thr Ile Glu Glu Gln Met Gln 
                 325                330                335
Arg Gly Asp Thr Ala Asp Ala Arg Pro Pro Thr Pro Leu Leu Pro Gly 
             340                345                350
His Pro Thr Ala Ser Ser Thr Ser Ile Lys Val Arg Gln Val Leu Ser 
         355                360                365
Pro Gly Phe Pro Glu Pro Pro Lys Thr Ser Ser Pro Leu Gly Ile Ser 
     370                375                380
Ala Val Leu Leu Glu Lys Lys Ser Pro Leu Gly Gln Ser Gln Pro Thr 
 385                390                395                400
Val Val Gly Gln Pro Ser Ala Arg Pro Ser Ala Glu Glu Tyr Gly Tyr 
                 405                410                415
Ile Val Thr Asp Gln Lys Pro Leu Ser Leu Val Ala Gly Val Lys Leu 
             420                425                430
Leu Glu Ile Leu Ala Glu His Val His Met Thr Ser Gly Ser Phe Ile 
         435                440                445
Asn Ile Ser Val Val Gly Pro Ala Val Thr Phe Arg Ile Arg His Asn 
     450                455                460
Glu Gln Asn Leu Ser Leu Ala Asp Val Thr Gln Gln Ala Gly Leu Val 
 465                470                475                480
Lys Ser Glu Leu Glu Ala Gln Thr Gly Leu Gln Ile Leu Gln Thr Gly 
                 485                490                495
Val Gly Gln Arg Glu Glu Ser Ala Ala Val Leu Pro Arg Gln Ala His 
             500                505                510
Arg Ile Ser Pro Met Arg Ser Leu Leu Leu Thr Leu Val Ala Leu Ala 
         515                520                525
Gly Val Ala Gly Leu Leu Val Ala Leu Ala Val Ala Leu Cys Met Arg 
     530                535                540
His His Ser Lys Gln Arg Asp Lys Glu Arg Leu Ala Ala Leu Gly Pro 
 545                550                555                560
Glu Gly Ala His Gly Asp Thr Thr Phe Glu Tyr Gln Asp Leu Cys Arg 
                 565                570                575
Gln His Met Ala Thr Lys Ser Leu Phe Asn Arg Ala Glu Gly Gln Pro 
             580                585                590
Glu Pro Ser Arg Val Ser Ser Val Ser Ser Gln Phe Ser Asp Ala Ala 
         595                600                605
Gln Ala Ser Pro Ser Ser His Ser Ser Thr Pro Ser Trp Cys Glu Glu 
     610                615                620
Pro Ala Gln Ala Asn Met Asp Ile Ser Thr Gly His Met Ile Leu Ala 
 625                630                635                640
Tyr Met Glu Asp His Leu Arg Asn Arg Asp Arg Leu Ala Lys Glu Trp 
                 645                650                655
Gln Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn Thr Cys Ala Thr Ala 
             660                665                670
Gln Gly Glu Gly Asn Ile Lys Lys Asn Arg His Pro Asp Phe Leu Pro 
         675                680                685
Tyr Asp His Ala Arg Ile Lys Leu Lys Val Glu Ser Ser Pro Ser Arg 
     690                695                700
Ser Asp Tyr Ile Asn Ala Ser Pro Ile Ile Glu His Asp Pro Arg Met 
 705                710                715                720
Pro Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ser His Thr Ile Ala Asp 
                 725                730                735
Phe Trp Gln Met Val Trp Glu Ser Gly Cys Thr Val Ile Val Met Leu 
             740                745                750
Thr Pro Leu Val Glu Asp Gly Val Lys Gln Cys Asp Arg Tyr Trp Pro 
         755                760                765
Asp Glu Gly Ser Ser Leu Tyr His Val Tyr Glu Val Asn Leu Val Ser 
     770                775                780
Glu His Ile Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys 
 785                790                795                800
Asn Val Gln Thr Gln Glu Thr Arg Thr Leu Thr Gln Phe His Phe Leu 
                 805                810                815
Ser Trp Pro Ala Glu Gly Thr Pro Ala Ser Thr Arg Pro Leu Leu Asp 
             820                825                830
Phe Arg Arg Lys Val Asn Lys Cys Tyr Arg Gly Arg Ser Cys Pro Ile 
         835                840                845
Ile Val His Cys Ser Asp Gly Ala Gly Arg Thr Gly Thr Tyr Ile Leu 
     850                855                860
Ile Asp Met Val Leu Asn Arg Met Ala Lys Gly Val Lys Glu Ile Asp 
 865                870                875                880
Ile Ala Ala Thr Leu Glu His Val Arg Asp Gln Arg Pro Gly Leu Val 
                 885                890                895
Arg Ser Lys Asp Gln Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu 
             900                905                910
Val Asn Ala Ile Leu Lys Ala Leu Pro Gln Ter 
         915                920



<210> 2015
<211> 3613
<212> DNA
<213> Homo sapiens
<308> L18983
<400> 2015

cagcccctc  ggcaggctc  cgccagcgt  gctgcggct  cggcccggg  gcgagcgcc  60
ggagctcgg  aagatgcgg  gcccgcggc  gcctggggg  ctcggggga  ccgggggtc  120
ccggctgct  ctctgcctc  tgctgctga  cagccgccc  gggggctgc  gcgccgtta  180
tgcccacgg  tgtctattt  accgcaggc  ctgctctca  ctggaagtc  gtattcagg  240
tggcttgtt  gggcagtgc  aggtgggag  ggggcaggc  cggcccctt  tgcaagtca  300
ctccccagt  ctccaacgc  tacaaggtg  gctccgaca  ctcatgtcc  aaggattgt  360
ctggcacga  gacctcacc  agtatgtga  ctctcagga  atggagcgc  tccccaggc  420
tcgcccccc  gagccccgt  caagggaca  gtctggctt  gcacccaag  gacctggtc  480
tgctggaga  ctgctttta  aggacatcc  cactggctc  gcccctgct  cccagcatc  540
gcttccaca  ccaccagtg  gcaaaggtg  agctggggc  agctcctct  tgtcccctc  600
gcaggctga  ctgctcccg  ctctcttgg  gcacctgct  ctgccccca  agcctcccc  660
cccttcact  agttacgaa  ctgccttgc  gcagcccta  ctgttccac  agtttggct  720
ccgtgatgg  tccagggtc  cagagggct  cccagggat  gtcagtgtc  gccccctgc  780
caaggctga  gcccctgcc  tcttcagca  aactgcctc  aagggcata  ttggggacc  840
ccctggcca  tcctacggg  accttccag  gccttcacc  gcccagctt  ttcaagact  900
tgggctgct  tatctggcc  aggagttgc  agcacccag  agggccagg  tgccaaggc  960
gccagagca  gggagcagc  gccgggcag  ggactcccc  gagggctat  agaaggaag  1020
actagggga  cgtggagag  agcctgctt  cccagctgt  cagccagat  cggctctgc  1080
gaggctggc  gctgtgctg  cgggctatg  ggtagagct  cgtcagctg  cccctgagc  1140
gctctccac  ctcctgacc  tgctgcagc  actgcccaa  ggtgcagga  gaaatccgg  1200
aggggttgt  aatgttgga  ctgatatca  gaaaacaat  gaggggccg  tggagggca  1260
agacacagc  gagcttcca  cccgcacat  ccccatgcc  ggacacccc  ctgccagcc  1320
tacctccag  gaagtccag  aggtgccaa  ccctgtctc  tctgagcct  ccaaagctg  1380
cagaccccc  gtgacacct  tcctgctag  gaagaaaag  ccactgggc  agagccagc  1440
cacggtggc  ggacagccc  cagcccgcc  agcagcaga  gaatatggc  acatcgtca  1500
tgatcagaa  cccctgagc  tggctgcag  agtgaagct  ctggagatc  tggctgagc  1560
tgtgcacat  tcctcaggc  gcttcatca  catcagtgt  gtgggacca  ccctcacct  1620
ccgcatccg  cacaatgag  agaacctgt  tttggctga  gtgacccaa  aagcagggc  1680
ggtgaagtc  gaactggaa  cacagacag  gctccaaat  ttgcagaca  gagtgggac  1740
gagggagga  gcagctgca  tccttcccc  aactgcgca  agcacctca  ccatgcgct  1800
agtgctgct  actctggtg  ccctggcag  tgtggctgg  ctgctggtg  ctctggctg  1860
ggctctgtg  gtgcggcag  atgcgcggc  gcaagacaa  gagcgcctg  cagccctgg  1920
gcctgaggg  gcccatggt  acactacct  tgagtacca  gacctgtgc  gccagcaca  1980
ggccacgaa  tccttgttc  accgggcag  gggtccacc  gagccttca  gggtgagca  2040
tgtgtcctc  cagttcagc  acgcagccc  ggccagccc  agctcccac  gcagcaccc  2100
gtcctggtg  gaggagccg  cccaagcca  catggacat  tccacggga  acatgattc  2160
ggcatacat  gaggatcac  tgcggaacc  ggaccgcct  gccaaggag  ggcaggccc  2220
ctgtgccta  caagcagag  caaacacct  tgccaccgc  cagggggag  gcaacatca  2280
aaagaaccg  catcctgac  tcctgccct  tgaccatgc  cgcataaaa  tgaaggtgg  2340
gagcagccc  tctcggagc  attacatca  cgccagccc  attattgag  atgaccctc  2400
gatgccagc  tacatagcc  cgcagggcc  gctgtccca  accatcgca  acttctggc  2460
gatggtgtg  gagagcggc  gcaccgtca  cgtcatgct  accccgctg  tggaggatg  2520
tgtcaagca  tgtgaccgc  actggccag  tgagggtgc  tccctctac  acgtatatg  2580
ggtgaacct  gtgtcggag  acatctggt  cgaggactt  ctggtgcgg  gcttctacc  2640
gaagaacgt  cagacccag  agacgcgca  gctcacgca  ttccacttc  tcagctggc  2700
ggcagaggg  acaccggcc  ccacgcggc  cctgctgga  ttccgcagg  aggtgaaca  2760
gtgctaccg  ggccgctcc  gccccatca  cgtgcactg  agtgatggt  cggggagga  2820
cggcaccta  atcctcatc  acatggtcc  gaaccgcat  gcaaaagga  tgaaggaga  2880
tgacatcgc  gccaccctg  agcatgtcc  tgaccagcg  cctggcctt  tccgctcta  2940
ggaccagtt  gaatttgcc  tgacagccg  ggcggagga  gtgaatgcc  tcctcaagg  3000
cctgcccca  tgagaccct  gggcccctt  gcgggcagc  cagcctctg  ccctctttg  3060
ctgtgtgag  atctctgtg  acccactcc  cactgcccc  ccagccacc  cttgggcat  3120
ctcagccct  cctagaaga  tcaggaagg  aaagccaga  ggggcacgc  tgcccagcc  3180
cgcatgcca  agcctgggg  atcccagag  ccagggcat  ccatggggg  gctgcagcc  3240
ggaggagag  aaaggacat  ggtagcaat  ctacccaga  ccttctcct  cctacattc  3300
ctggcctgg  tctcctgta  ctctcctgg  gttctggga  ttccctgaa  atctgtgtg  3360
gtcccccta  gctccagta  ggaagaatg  ggtggaggg  cgccacacc  ggctccccc  3420
gcttctcag  cccgggcct  cctctgact  acacttggg  gctctgccc  ccctggcct  3480
acgcccagc  tggtcccac  accctccca  catgcgctg  tcaacctct  tccttctgg  3540
gcaagagaa  atttctaga  aaaactact  ttgtaccag  gtgaataaa  ttagtgtgt  3600
gtctgtgca  ctg  3613



<210> 2016
<211> 979
<212> PRT
<213> Homo sapiens
<308> Q16849
<400> 2016

Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu 
  1               5                  10                  15
Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys 
             20                  25                  30
Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser 
         35                  40                  45
His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val 
     50                  55                  60
Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu 
 65                  70                  75                  80
Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser 
                 85                  90                  95
Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg 
             100                105                110
Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly 
         115                120                125
Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp 
     130                135                140
Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro 
 145                150                155                160
Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu 
                 165                170                175
Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro 
             180                185                190
Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro 
         195                200                205
Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu 
     210                215                220
Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala 
 225                230                235                240
Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His 
                 245                250                255
Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu 
             260                265                270
Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro 
         275                280                285
Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg 
     290                295                300
Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg 
 305                310                315                320
Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln 
                 325                330                335
Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu 
             340                345                350
Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro 
         355                360                365
Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp 
     370                375                380
Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu 
 385                390                395                400
Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro 
                 405                410                415
Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro 
             420                425                430
Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys 
         435                440                445
Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala 
     450                455                460
Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro 
 465                470                475                480
Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His 
                 485                490                495
Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro 
             500                505                510
Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala 
         515                520                525
Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln 
     530                535                540
Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala 
 545                550                555                560
Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser 
                 565                570                575
Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val 
             580                585                590
Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp 
         595                600                605
Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr 
     610                615                620
Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser 
 625                630                635                640
Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser 
                 645                650                655
Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His 
             660                665                670
Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp 
         675                680                685
Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg 
     690                695                700
Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln 
 705                710                715                720
Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys 
                 725                730                735
Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys 
             740                745                750
Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser 
         755                760                765
Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln 
     770                775                780
Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu 
 785                790                795                800
Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly 
                 805                810                815
Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr 
             820                825                830
His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp 
         835                840                845
Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr 
     850                855                860
Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr 
 865                870                875                880
Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys 
                 885                890                895
Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly 
             900                905                910
Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg 
         915                920                925
Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His 
     930                935                940
Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu 
 945                950                955                960
Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala 
                 965                970                975
Leu Pro Gln 
             980



<210> 2017
<211> 1097
<212> DNA
<213> Rattus norvegicus
<308> D38455
<400> 2017

ggagagagg  gccgagaca  ccaagatgc  gaagctgct  ctgctgctg  cactgtccc  60
cctggctag  ctggtgcac  cggcccctt  cccagtcaa  cagcgagtg  gcattgtgg  120
aggacgaga  gcttctgaa  gtaagtggc  ctggcaggt  agcctgaga  ttaaattca  180
cttctggat  catttctgt  gcggctccc  cattcaccc  cagtgggtg  tcactgcgg  240
acactgtgt  ggactgcac  tcaaaagcc  agagctctt  cgtgtacag  ttcgtgagc  300
gtatctata  tatgcggac  agctactga  tgtgaaccg  accgttgtg  acccccact  360
ctacacagt  gaggatggg  cagacattg  cctgctgga  cttgagatc  ctgtgaatg  420
ctccaccca  atccacccc  tatccctgc  ccctgcctc  gagaccttc  cctcgggga  480
ttcttgctg  gtaacaggc  ggggcgaca  tgatagtga  gagcctctc  tgccacctt  540
tcctctgaa  caagtgaag  tccccattg  ggaaaacag  ctgtgtgat  ggaagtacc  600
cactggcct  tacacagga  atgatgttc  cattgtcca  gatggcatg  tgtgtgctg  660
aaataccag  agcgactcc  gccagggag  ctcaggggg  ccactggtc  gcaaagtga  720
gggtacctg  ctgcaagca  gagtggtca  ctggggtga  ggctgcgca  aggccaatc  780
tcctggcat  tacacccgg  tgacgtact  cctggactg  attcaccgc  atgtccctc  840
gcgttcctg  gacccatcc  gggtcaggg  agaaccagg  acctgctgt  tttaactca  900
tgcttcctg  ccagatgga  ccctggcct  ctttgtact  tgtctcccc  gtctaccgg  960
tgtccctct  agcccccac  ttgttccac  ttgagtccc  cgccactcc  gtcccctct  1020
cctcccacc  caacacagc  gcactgtgc  gctccctct  ttctgtggc  cattaaagt  1080
tgtgaaaat  ttgctcc  1097



<210> 2018
<211> 274
<212> PRT
<213> Rattus norvegicus
<308> P50343
<400> 2018

Met Leu Lys Leu Leu Leu Leu Leu Ala Leu Ser Pro Leu Ala Ser Leu 
  1               5                  10                  15
Val His Ala Ala Pro Cys Pro Val Lys Gln Arg Val Gly Ile Val Gly 
             20                  25                  30
Gly Arg Glu Ala Ser Glu Ser Lys Trp Pro Trp Gln Val Ser Leu Arg 
         35                  40                  45
Phe Lys Phe Ser Phe Trp Met His Phe Cys Gly Gly Ser Leu Ile His 
     50                  55                  60
Pro Gln Trp Val Leu Thr Ala Ala His Cys Val Gly Leu His Ile Lys 
 65                  70                  75                  80
Ser Pro Glu Leu Phe Arg Val Gln Leu Arg Glu Gln Tyr Leu Tyr Tyr 
                 85                  90                  95
Ala Asp Gln Leu Leu Thr Val Asn Arg Thr Val Val His Pro His Tyr 
             100                105                110
Tyr Thr Val Glu Asp Gly Ala Asp Ile Ala Leu Leu Glu Leu Glu Ile 
         115                120                125
Pro Val Asn Val Ser Thr His Ile His Pro Ile Ser Leu Pro Pro Ala 
     130                135                140
Ser Glu Thr Phe Pro Ser Gly Thr Ser Cys Trp Val Thr Gly Trp Gly 
 145                150                155                160
Asp Ile Asp Ser Asp Glu Pro Leu Leu Pro Pro Tyr Pro Leu Lys Gln 
                 165                170                175
Val Lys Val Pro Ile Val Glu Asn Ser Leu Cys Asp Arg Lys Tyr His 
             180                185                190
Thr Gly Leu Tyr Thr Gly Asp Asp Val Pro Ile Val Gln Asp Gly Met 
         195                200                205
Leu Cys Ala Gly Asn Thr Arg Ser Asp Ser Cys Gln Gly Asp Ser Gly 
     210                215                220
Gly Pro Leu Val Cys Lys Val Lys Gly Thr Trp Leu Gln Ala Gly Val 
 225                230                235                240
Val Ser Trp Gly Glu Gly Cys Ala Glu Ala Asn Arg Pro Gly Ile Tyr 
                 245                250                255
Thr Arg Val Thr Tyr Tyr Leu Asp Trp Ile His Arg Tyr Val Pro Gln 
             260                265                270
Arg Ser 
         275



<210> 2019
<211> 1142
<212> DNA
<213> Homo sapiens
<308> XM_018104
<400> 2019

gatgctgaa  ctgctgctg  tggcgctgc  cgtcctggc  agccgcgcc  acgcggccc  60
tgccccagg  caggccctg  agcgagtgg  catcgttgg  ggtcaggag  cccccagga  120
caagtggcc  tggcaggtg  gcctgagag  ccgcgaccg  tactggatg  acttctgcg  180
gggctccct  atccacccc  agtgggtgc  gaccgcagc  cactgcgtg  gaccggacg  240
caaggatct  gccgccctc  gggtgcaac  gcgggagca  cacctctac  accaggacc  300
gctgctgcc  gtcagcagg  tcatcgtgc  cccacagtt  tacaccgcc  agatcggag  360
ggacatcgc  ctgctggag  tggaggagc  ggtgaacgt  tccagccac  tccacacgg  420
caccctgcc  cctgcctca  agaccttcc  cccggggat  ccgtgctgg  tcactggct  480
gggcgatgt  gacaatgat  agcgcctcc  accgccatt  cctctgaag  aggtgaagg  540
ccccataat  gaaaaccac  tttgtgacg  aaaatacca  cttggcgcc  acacgggag  600
cgacgtccg  atcgtccgt  acgacatgc  gtgtgccgg  aacacccgg  gggactcat  660
ccagggcga  tccggaggg  ccctggtgt  caaggtgaa  ggcacctgg  tgcaggcgg  720
cgtggtcag  tggggcgag  gctgtgccc  gcccaaccg  cctggcatc  acacccgtg  780
cacctacta  ttggactgg  tccaccact  tgtccccaa  aagccgtga  tcaggcctg  840
ggtgtccac  tgggtcact  gagagccag  ccctcctgt  caaaacacc  ctgcttcct  900
cccaggtgg  gactgcccc  cacaccttc  ctgccccgt  ctgagtgcc  cttcctgtc  960
taagccccc  gctctcttc  gagcccctt  ccctgtcct  aggaccctt  cccatcctg  1020
gcccccttc  ctgtcctaa  cctgacgcc  gcaccgggc  ctccggccc  cccctgccc  1080
ggcagctgg  ggtgggcgc  aatcctcct  agtgctgga  ctcattaaa  tgcatggaa  1140
tc  1142



<210> 2020
<211> 275
<212> PRT
<213> Homo sapiens
<308> XP_018104
<400> 2020

Met Leu Asn Leu Leu Leu Leu Ala Leu Pro Val Leu Ala Ser Arg Ala 
  1               5                  10                  15
Tyr Ala Ala Pro Ala Pro Gly Gln Ala Leu Gln Arg Val Gly Ile Val 
             20                  25                  30
Gly Gly Gln Glu Ala Pro Arg Ser Lys Trp Pro Trp Gln Val Ser Leu 
         35                  40                  45
Arg Val Arg Asp Arg Tyr Trp Met His Phe Cys Gly Gly Ser Leu Ile 
     50                  55                  60
His Pro Gln Trp Val Leu Thr Ala Ala His Cys Val Gly Pro Asp Val 
 65                  70                  75                  80
Lys Asp Leu Ala Ala Leu Arg Val Gln Leu Arg Glu Gln His Leu Tyr 
                 85                  90                  95
Tyr Gln Asp Gln Leu Leu Pro Val Ser Arg Ile Ile Val His Pro Gln 
             100                105                110
Phe Tyr Thr Ala Gln Ile Gly Ala Asp Ile Ala Leu Leu Glu Leu Glu 
         115                120                125
Glu Pro Val Asn Val Ser Ser His Val His Thr Val Thr Leu Pro Pro 
     130                135                140
Ala Ser Glu Thr Phe Pro Pro Gly Met Pro Cys Trp Val Thr Gly Trp 
 145                150                155                160
Gly Asp Val Asp Asn Asp Glu Arg Leu Pro Pro Pro Phe Pro Leu Lys 
                 165                170                175
Gln Val Lys Val Pro Ile Met Glu Asn His Ile Cys Asp Ala Lys Tyr 
             180                185                190
His Leu Gly Ala Tyr Thr Gly Asp Asp Val Arg Ile Val Arg Asp Asp 
         195                200                205
Met Leu Cys Ala Gly Asn Thr Arg Arg Asp Ser Cys Gln Gly Asp Ser 
     210                215                220
Gly Gly Pro Leu Val Cys Lys Val Asn Gly Thr Trp Leu Gln Ala Gly 
 225                230                235                240
Val Val Ser Trp Gly Glu Gly Cys Ala Gln Pro Asn Arg Pro Gly Ile 
                 245                250                255
Tyr Thr Arg Val Thr Tyr Tyr Leu Asp Trp Ile His His Tyr Val Pro 
             260                265                270
Lys Lys Pro 
         275



<210> 2021
<211> 3214
<212> DNA
<213> Rattus norvegicus
<308> D38492
<400> 2021

ccgccaaag  ggcaatttg  agcagatat  ataccgaga  cggcagatg  ttcaacaca  60
acggtcttt  atagttgtc  actgccata  agctcccat  ccttctgga  actgaccca  120
ctattcaac  gaagatgaa  accccattg  tggtcagtc  tctcctgct  atctcctta  180
catcctgtc  aggagagtt  acatggcac  gaagatatg  tcatggagt  tctgaggag  240
ataaaggat  tggacccat  tttgaagag  aaccaatca  taccattta  ccagaagag  300
cactggaag  caaagtgtc  ctcaactgc  gggcacggg  aagcccatt  ccggtttac  360
agtggagaa  gaataacgg  gacgttgac  tgacgaacg  tcgatacag  atggtcgga  420
ggaaccttg  tatcaataa  cctgacaaa  agaaagacg  aggaatata  tactgcttg  480
cgtccaaca  ctacgggat  gtcagaagc  ccgaggcca  cctgagctt  gggtatctt  540
acccctttc  tcctgagga  cgtcctgaa  tgaaggtga  ggaagggaa  ggcatggtg  600
ttctctgcg  ccctcccta  cacttccca  acgatctta  ctaccgctg  cttctgaat  660
aatttcccg  ctttatcac  atggataag  gaagattcg  gtctcagac  aacggtaat  720
tctacatcg  gaacgttga  tcttctgat  gaggcaact  ttcctgctt  gtgtccagc  780
cttctatta  aaagagcgt  ttcagcaaa  ttatacccc  cattccgat  cctgagcga  840
caacgaagc  atatcctgc  gacattgta  tgcagttca  ggacatata  accatgatg  900
gccaaaatg  gaccttaga  tgcttcgct  ttggaaacc  tgttcctga  attcggtgg  960
ggaaggtgc  agaacccat  cctaccaca  ctgagatca  cacctcagg  gctgtcctc  1020
agatcttca  catccagct  gaagatgaa  ggctctacg  gtgcgaggc  gagaacatt  1080
ggggaaagg  caagcacca  gcaagaatt  atgttcaag  atttcctga  tgggtagag  1140
atatcaatg  cactgaagt  gacataggc  gtgacctct  ctggccttg  gtggccaca  1200
ggaagccca  ccctaccat  aggtggctg  aaaatgggt  cgcgtatca  aaaggggaa  1260
tgaggctgt  tgacgtgac  tttgaaaac  ccgggatgt  ccagtgcat  gcagaaaac  1320
cgtatggga  catttatgc  aatgctgaa  tcaagatcc  ggctttagc  ccaactttt  1380
aaatgaatc  catgaagaa  aagatcctg  ctgcgaaag  aggaagggt  atcattgag  1440
gcaaaccca  ggctgcacc  aaacccaag  tttcatgga  caaagggac  gagtggctt  1500
tcaacagca  cagaatact  atatgggaa  atggtagct  ggaaatcaa  aatattaca  1560
gaaatgatg  aggaatcta  acatgcttt  cagaaaaca  cagagggaa  gctaatagc  1620
ccgggactc  ggtgatcac  aatcccaca  gaatcattt  ggccccaat  aatgctgat  1680
tcactgttg  agaaaacgc  accatgcag  gtgctgcct  ctttgatcc  tccttggat  1740
tcacgttcg  ctggtcttt  aatggctac  tgattgact  taacaagga  attacaaat  1800
ttcattacc  gaggaattt  atgctcgac  ccaatgggg  actgctcat  cgaaacgcg  1860
agctgaaac  cgcaggacg  tacacgtgc  cagcgcaga  aatcgtgga  aattcttca  1920
cttcagctg  ccttgtcgt  cgaggcccc  caggccctc  aggtggcct  agaatagaa  1980
acatcagag  tacctctgt  gcactgact  ggagccgtg  ttcagacaa  cacagccct  2040
tctctaaat  cactatcca  accaagacg  ttctctcag  tgactggaa  gacgcaaag  2100
cggatcccc  aatcattga  ggaaacatg  agtcagcaa  agcagtcga  ttgatccca  2160
ggatggagt  cgaatttcg  gtggtagca  ccaatactt  ggggactgg  gagcccagc  2220
taccctcaa  caggatcaa  accgatggc  ctgcaccaa  tgtggctcc  tcagacgta  2280
gtggtgggg  cggaaccaa  agagagctg  caataacgt  ggcgccttt  tccagagaa  2340
accattatg  taacaattt  ggttacata  tggcattca  gccattcga  ggagaagag  2400
ggaagaaag  gaccgttac  aatccggat  ctggccgct  cgtccacaa  gacgaaacc  2460
tgacccctt  caccgcgtt  caagtcaaa  tgaaggcat  caacaataa  ggagacggg  2520
cctacagcc  catagctgt  atcaactca  cacaagacg  tcccagtga  gcccccaca  2580
aagtagggg  caaagtgct  tcgtcctct  agatctctg  ccattggaa  cacgttcta  2640
agaagattg  ggaaagcta  caaattcgg  actgggccg  tcacgacaa  gaagcagcg  2700
cgcacagag  tcaagtcac  agccaggag  actcagcca  gctggagaa  cttctgccg  2760
acactcagt  cttcataga  gtgggagcc  gtaacagcg  ggggtgcgg  ccttccagc  2820
acgtgatcg  gaccttcac  agaaaagcc  ctcccagcc  accaccaag  atcatcagt  2880
ccgtgaggt  tggctcccg  tacataatc  cgtgggatc  tgtcgtggc  ctatccaat  2940
aatctacag  gacaggcta  aagatactc  atagacctg  cggccaaca  gacggtaag  3000
tgttctcca  gcacaagca  tccatagaa  tccccatcc  cagagacgg  gagtacgta  3060
tcgaagttc  agcacacag  gatggagga  atggggtag  gtcccaagt  aaaatttca  3120
gtgtgtcca  gctgtcatc  ggtctcctc  gcttgctcc  gccctccct  ggctttctt  3180
tcttctatt  ggaattctg  acgttgtga  attt  3214



<210> 2022
<211> 1021
<212> PRT
<213> Rattus norvegicus
<308> Q63198
<400> 2022

Met Lys Thr Pro Leu Leu Val Ser His Leu Leu Leu Ile Ser Leu Thr 
  1               5                  10                  15
Ser Cys Leu Gly Glu Phe Thr Trp His Arg Arg Tyr Gly His Gly Val 
             20                  25                  30
Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
         35                  40                  45
Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
     50                  55                  60
Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr Lys Trp Arg Met Asn 
 65                  70                  75                  80
Asn Gly Asp Val Asp Leu Thr Asn Asp Arg Tyr Ser Met Val Gly Gly 
                 85                  90                  95
Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys Asp Ala Gly Ile Tyr 
             100                105                110
Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val Arg Ser Thr Glu Ala 
         115                120                125
Thr Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro Pro Glu Asp Arg Pro 
     130                135                140
Glu Val Lys Val Lys Glu Gly Lys Gly Met Val Leu Leu Cys Asp Pro 
 145                150                155                160
Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg Trp Leu Leu Asn Glu 
                 165                170                175
Phe Pro Val Phe Ile Thr Met Asp Lys Arg Arg Phe Val Ser Gln Thr 
             180                185                190
Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ser Ser Asp Arg Gly Asn 
         195                200                205
Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Thr Lys Ser Val Phe Ser 
     210                215                220
Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg Thr Thr Lys Pro Tyr 
 225                230                235                240
Pro Ala Asp Ile Val Val Gln Phe Lys Asp Ile Tyr Thr Met Met Gly 
                 245                250                255
Gln Asn Val Thr Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Asp 
             260                265                270
Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro Thr Thr Ala Glu Ile 
         275                280                285
Ser Thr Ser Gly Ala Val Leu Lys Ile Phe Asn Ile Gln Leu Glu Asp 
     290                295                300
Glu Gly Leu Tyr Glu Cys Glu Ala Glu Asn Ile Arg Gly Lys Asp Lys 
 305                310                315                320
His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro Glu Trp Val Glu His 
                 325                330                335
Ile Asn Asp Thr Glu Val Asp Ile Gly Ser Asp Leu Tyr Trp Pro Cys 
             340                345                350
Val Ala Thr Gly Lys Pro Ile Pro Thr Ile Arg Trp Leu Lys Asn Gly 
         355                360                365
Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr Asp Val Thr Phe Glu 
     370                375                380
Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn Ala Tyr Gly Thr Ile 
 385                390                395                400
Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu Ala Pro Thr Phe Glu 
                 405                410                415
Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala Lys Gly Gly Arg Val 
             420                425                430
Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys Pro Lys Phe Ser Trp 
         435                440                445
Ser Lys Gly Thr Glu Trp Leu Val Asn Ser Ser Arg Ile Leu Ile Trp 
     450                455                460
Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Thr Arg Asn Asp Gly Gly 
 465                470                475                480
Ile Tyr Thr Cys Phe Ala Glu Asn Asn Arg Gly Lys Ala Asn Ser Thr 
                 485                490                495
Gly Thr Leu Val Ile Thr Asn Pro Thr Arg Ile Ile Leu Ala Pro Ile 
             500                505                510
Asn Ala Asp Ile Thr Val Gly Glu Asn Ala Thr Met Gln Cys Ala Ala 
         515                520                525
Ser Phe Asp Pro Ser Leu Asp Leu Thr Phe Val Trp Ser Phe Asn Gly 
     530                535                540
Tyr Val Ile Asp Phe Asn Lys Glu Ile Thr Asn Ile His Tyr Gln Arg 
 545                550                555                560
Asn Phe Met Leu Asp Ala Asn Gly Glu Leu Leu Ile Arg Asn Ala Gln 
                 565                570                575
Leu Lys His Ala Gly Arg Tyr Thr Cys Thr Ala Gln Thr Ile Val Asp 
             580                585                590
Asn Ser Ser Ala Ser Ala Asp Leu Val Val Arg Gly Pro Pro Gly Pro 
         595                600                605
Pro Gly Gly Leu Arg Ile Glu Asp Ile Arg Ala Thr Ser Val Ala Leu 
     610                615                620
Thr Trp Ser Arg Gly Ser Asp Asn His Ser Pro Ile Ser Lys Tyr Thr 
 625                630                635                640
Ile Gln Thr Lys Thr Ile Leu Ser Asp Asp Trp Lys Asp Ala Lys Thr 
                 645                650                655
Asp Pro Pro Ile Ile Glu Gly Asn Met Glu Ser Ala Lys Ala Val Asp 
             660                665                670
Leu Ile Pro Trp Met Glu Tyr Glu Phe Arg Val Val Ala Thr Asn Thr 
         675                680                685
Leu Gly Thr Gly Glu Pro Ser Ile Pro Ser Asn Arg Ile Lys Thr Asp 
     690                695                700
Gly Ala Ala Pro Asn Val Ala Pro Ser Asp Val Gly Gly Gly Gly Gly 
 705                710                715                720
Thr Asn Arg Glu Leu Thr Ile Thr Trp Ala Pro Leu Ser Arg Glu Tyr 
                 725                730                735
His Tyr Gly Asn Asn Phe Gly Tyr Ile Val Ala Phe Lys Pro Phe Asp 
             740                745                750
Gly Glu Glu Trp Lys Lys Val Thr Val Thr Asn Pro Asp Thr Gly Arg 
         755                760                765
Tyr Val His Lys Asp Glu Thr Met Thr Pro Ser Thr Ala Phe Gln Val 
     770                775                780
Lys Val Lys Ala Phe Asn Asn Lys Gly Asp Gly Pro Tyr Ser Leu Ile 
 785                790                795                800
Ala Val Ile Asn Ser Ala Gln Asp Ala Pro Ser Glu Ala Pro Thr Glu 
                 805                810                815
Val Gly Val Lys Val Leu Ser Ser Ser Glu Ile Ser Val His Trp Lys 
             820                825                830
His Val Leu Glu Lys Ile Val Glu Ser Tyr Gln Ile Arg Tyr Trp Ala 
         835                840                845
Gly His Asp Lys Glu Ala Ala Ala His Arg Val Gln Val Thr Ser Gln 
     850                855                860
Glu Tyr Ser Ala Arg Leu Glu Asn Leu Leu Pro Asp Thr Gln Tyr Phe 
 865                870                875                880
Ile Glu Val Gly Ala Cys Asn Ser Ala Gly Cys Gly Pro Ser Ser Asp 
                 885                890                895
Val Ile Glu Thr Phe Thr Arg Lys Ala Pro Pro Ser Gln Pro Pro Arg 
             900                905                910
Ile Ile Ser Ser Val Arg Ser Gly Ser Arg Tyr Ile Ile Thr Trp Asp 
         915                920                925
His Val Val Ala Leu Ser Asn Glu Ser Thr Val Thr Gly Tyr Lys Ile 
     930                935                940
Leu Tyr Arg Pro Asp Gly Gln His Asp Gly Lys Leu Phe Ser Thr His 
 945                950                955                960
Lys His Ser Ile Glu Val Pro Ile Pro Arg Asp Gly Glu Tyr Val Val 
                 965                970                975
Glu Val Arg Ala His Ser Asp Gly Gly Asp Gly Val Val Ser Gln Val 
             980                985                990
Lys Ile Ser Gly Val Ser Thr Leu Ser Ser Gly Leu Leu Ser Leu Leu 
         995                1000                1005
Leu Pro Ser Leu Gly Phe Leu Val Phe Tyr Ser Glu Phe 
     1010                1015                1020



<210> 2023
<211> 8582
<212> DNA
<213> Rattus norvegicus
<308> D38629
<400> 2023

agtagtgaa  ttcaaaatc  tttttaacc  tataggtcc  agggtagcc  aggatggca  60
cagcctcat  tgatcagtt  ttaaagcaa  ttgaggccc  gaagatgga  aactcaaat  120
ttcgacaag  gctcgaaga  aattccaat  accttacag  actggaaac  gaggcatct  180
acatgaagg  agtacttaa  cagctgcag  gaagtattg  agatgagac  atgacttcc  240
gacagattg  tttactaga  cgccttaaa  aatttaact  agatagcaa  ttccccgga  300
tgaaactac  ctcgaaaat  tccctccga  cctatggaa  tcgggaagg  tctgtatca  360
gccgttcag  agaatgcag  cctgtcccc  tggggtcat  cccaagaag  gcatttgta  420
atggaagca  agaaagcac  ggatactta  aagagcttg  gaaagagag  tcattactc  480
ttgctgatc  tgacaaaga  gaaaaggaa  aggactggt  ttatgctca  cttcagaac  540
tcacgaaaa  aatagatag  ctgcccttg  ctgagaact  ttccttaca  acagacatg  600
caagacggc  gctggagta  gaagcacgg  agatcaggg  cgcaatgga  gagcagctt  660
gcacctgcc  ggacatgga  aaacgagca  agcgaagaa  agccaggat  cagcaaata  720
agaaggaca  tcttcgtgt  cggcagctc  tacagtccc  agcggctga  gcagagagg  780
catctcaga  caagcatga  actgcctcc  atgaagctg  gcggcagct  gaaggtcaa  840
gagtggcag  aagcaactt  gcaacttct  gtagtggcc  gagttcagc  gcacgtgtg  900
atcatgaaa  agccggtgt  ttgagttct  gcggcacac  ctctgctcc  cgaaggctg  960
cgagtcacc  gggaacgaa  gtggaaatg  tgtattcat  gttgtccat  cttggtact  1020
atgataagg  cgatatgtc  cgaactttg  tagctatgt  tagctccca  gacagctgt  1080
tatccatgc  acagtctgg  tgtcttcct  tcctcatcc  gcttttaca  ggcaatgac  1140
aagactctg  gttgttggg  aattcccgg  gcagtaaag  ggctcgggc  agggccagt  1200
cagccctcc  caacatcat  cactcacag  ctgatgaca  gagaggcag  cgtgaaatc  1260
gggtccttc  tcttttgga  cagatacga  cttactgcg  aacctgttg  gagtggcag  1320
aagcccatg  acaaggcat  gaccaggac  aaaatccaa  gccagctcc  gttgagcat  1380
agatctgcc  tgcggtgtg  gttctgatg  aactctcat  tgatgagga  cacagacat  1440
cgatgaatg  gcttggggg  ctgcaggct  ttgcagagt  actgcaggt  gactgtgag  1500
tgcacgggc  cactgatga  cactacagt  tcactctac  acggtacgc  ggaatggcc  1560
tgacaaacc  gacctttgg  gatgttgcc  acaaggcta  gctgtgttc  atgaaaggc  1620
gcatgaggg  actcgtggc  cagttaaaa  ccgaaagtg  agacttaca  caggttatt  1680
caagtgttt  gcggaattt  tcttggcga  cagatgtaa  tagcaaaaa  acgttgaga  1740
aagttggaa  tgtgaaagc  ttgatggaa  gtgctttgg  agttaaaaa  gaatcaact  1800
tcaaaagcg  cttgagtgc  ttatggaat  tgtccgcac  ctgcactga  aataaggct  1860
acatatgtg  tgtggacgg  gcactggca  ttctggttg  caccctcac  taccggagc  1920
agacaaata  gttagccat  attgaaagt  gaggtggga  attacggaa  gtgtccagc  1980
tgatagcta  caacgaaga  cacagacaa  tcctaagag  gaacaactg  ctacaaact  2040
tattacagc  cttgaaatc  cacagcttg  caatagtca  taatgcatg  ggaactctg  2100
ggaatctct  agcgagaaa  cctaaagac  aggaggctc  gtgggacat  ggggcggtg  2160
gcatgctca  gaacctcat  cattccaag  acaaaatga  cgctatggg  agcgcagca  2220
ctttaagga  tctcatggc  aacagacct  caaagtata  ggatgccaa  atcatgtct  2280
ctggctcaa  tttgccatc  cttcacgtt  ggaaacaaa  agctctaga  gcagaatta  2340
acgctcagc  tttatcaga  acctttgac  atattgaca  tttaagtcc  aaggcatct  2400
atcgcagta  gcagagaca  aagcagaat  tttatggtg  ctatgtctt  gacgccagt  2460
gacatgatg  caataggtc  gacaacttt  acactggaa  catgactgt  ctttcacca  2520
acttaaata  cacagtatt  cccagctct  cttcatcaa  gggaagttt  gacagttct  2580
gttctgaga  agacagaag  ttggagaga  aacgaggta  tggcctcag  acttaccat  2640
cagcaacag  aaatccggg  acctcttcc  aacggggtt  gcagctctc  gccactgca  2700
cccagatag  caaagtgat  gaagaagtg  ccgccctcc  cacctccca  gacgacaga  2760
gccccgcct  tgccgctga  ctccactgt  tggcggagg  gaggactgc  gcacgaaga  2820
gctctgcgt  ccacacaca  ccaaacaca  acaacttcg  taagtcgga  agctcaaac  2880
ggacatgct  catgcctta  gccaaggtg  aatataaga  atcttcaaa  gacagctta  2940
acagtgtca  tagtagtga  ggctatggt  aaaggggcc  gatgaagcc  tcggttgag  3000
cctactcag  agatgatga  ggtaagttt  gcagttatg  gcagtatcc  gccgaccta  3060
cccataaga  acacagtgc  aatcatatg  atgataatg  tggggagct  gacacacca  3120
taaactaca  cctcaagta  tcagatgag  agctgaact  aggaaggca  agcccctca  3180
aaaatgaaa  gtgggcaag  cccaagcat  tgatagaag  tgaaataaa  caaaacgag  3240
aaaggcaat  aagaagcca  aacaccaat  ttcccgtct  ctctgagaa  actgatgac  3300
aacacctca  gttccaaca  cattttggg  aacaagagt  cgtttcccc  tataggtcc  3360
ggggaacca  tggttcaga  acaaatcga  tgggttcta  tcatgcagt  aatcaaaat  3420
tgaaccagt  tttgtgtca  gaagacgac  atgaagatg  caagcctac  aactacagt  3480
aacgttatt  tgaggaaga  cagcatgaa  aagaagaga  accgacaaa  tacagcata  3540
agtataatg  agagaaaca  catgtggat  agcctattg  ttatagtct  aaatatgcc  3600
ctgacatat  ttcatccca  aagccatca  tttcattct  aaagactcc  tcagtacag  3660
gcactaaaa  tgaacataa  tctccaagc  gtgaggctg  atctgcacc  tcatctaac  3720
ccaaaaggc  gagtcagct  catccaagt  cagcacaaa  aaatggtca  actccaaaa  3780
ggactgcct  caaagtccc  tccatcaac  aagagacaa  gcagactta  tgtgtagaa  3840
acaccccaa  atgtttctc  aggtgtagt  ccttatcat  gctatcatc  gctgaggat  3900
aaataggct  tgatcagac  acacaggag  cagactctg  gaatactct  caaatagca  3960
agataaaag  gaatgatgt  acgcggtca  ctcaagacc  tgcgagtga  gtcccagcc  4020
tgtcccaga  tactagaac  aagcccagc  gactccagg  ttccggctt  gcttcagaa  4080
ccgccaggc  taaagctgt  gagttttct  caggagcca  gtctccctc  aaaagcggt  4140
ctcagacac  caaaagtcc  ccagaacac  atgtccagg  gacgcccct  gtattcagc  4200
ggtgtactt  tgtcagctc  ctggacagt  ttgagagtc  ctccatcgc  agctctgtt  4260
agagtgagc  atgtagtgg  atggtgagt  ggattgtca  ccccagtga  cttccagac  4320
gcccagggc  gaccatgcc  ccaagcaga  gcaagaccc  tccccctcc  cctccccca  4380
agccagtgc  gaccaagag  gaggtgcca  aaactaagg  gcctgctgc  gagcagaga  4440
agggtgggc  taagcagac  gccgtgagt  cggctgtgc  gagggtgca  gtcctcccg  4500
atgccgaca  tctgttaca  tttgccaca  agagtactc  agatgggtt  tcttgttcc  4560
ctagcctaa  tgctctgag  ctggatgag  cctttatac  gaaagatgt  gaattaaga  4620
taatgcctc  agttcagga  aacgacaat  ggaatgaaa  tgaaccaga  cagcctgaa  4680
aatctaatg  aaaccagga  aaagaggta  aaaagcctg  ctctgaaaa  gacttatta  4740
atgattccg  tgatgatga  attgaaata  tagaagaat  tattatttc  gccatgcca  4800
caaagtcat  acgcaaagc  aaaaagcta  cccagactg  ttcaaaatt  cctcctcct  4860
tggcaagga  accgagtca  ctgcctgtg  acaaacttc  gccgtcaca  agcaggctg  4920
aggcacaaa  acatgtcag  tttacacca  gggacgatg  gccccgagt  tactgtgtg  4980
aagggacgc  tataaactt  tccacagca  catctctga  tgatctcac  atagaatcc  5040
ctccgaatg  gctggctgc  ggagatggg  ttagagcaa  tgtacagtc  ggtgagttt  5100
aaaaacgag  taccattcc  acagagggc  gaagtacag  tgaggctca  agaggaaaa  5160
tctcctcta  agctatacc  gacctggat  gtagcaaag  agaggaagg  gatattctt  5220
cagaatgca  caattctgc  ctgcccaaa  gaagaagcc  caagccttt  cgagtgaaa  5280
agataatgg  ccaagtcca  caggcatcc  tgacttcat  cggaactaa  aaaaatcaa  5340
tagacacta  gaaaaagaa  cctacttca  cagtaaagc  catgccaca  aatactgaa  5400
acagaactc  tgtgagaaa  aatacagac  caaaagtta  cgtaaatac  gaagaaact  5460
tctcagaca  taaagactc  aagaaacag  gcttaaaaa  caaccccaa  gacttgaat  5520
acaagctac  ggacaatga  gacagggtc  ggggaggct  tactttcga  tcaccgcat  5580
attacgcac  cattgaagg  actccttac  gcttctcac  aaatgactc  ttgagttct  5640
tagattttg  tgatgacga  gttgacctc  ccagggaaa  ggctgagtt  agaaagggc  5700
aagaaagta  ggactccga  gccaaagtt  cctgccaca  agaaccaag  tcaagccaa  5760
agtcggcta  gaaggcaca  gctagtaca  aacatccag  gaacagagg  ccgtctaaa  5820
cactgctgc  ggaacaacc  actttcccc  agtcctcta  agacgtacc  gacagaggg  5880
cagcaactg  cgaaaaact  cagaatttt  ctattgaaa  tacaccggt  tgcttttct  5940
gaaattctt  tctgagctc  cttagtgac  ttgaccaag  aaacaacaa  aacgaagaa  6000
ctggaccag  cagagacgc  gagcctgcc  acgcgcaag  acagccagg  aagcctcag  6060
catctgggt  tgcgcccaa  tcctttcat  tggaagaca  ccctgtgtg  ttctccaga  6120
acagctctc  cagctctct  agcattgat  ctgaggacg  cctgttgcg  gagtgcata  6180
gctctgcta  gccaaaaaa  aggaggcct  ccagactca  gggtgaggg  gagtggcag  6240
gtcctagga  agtgggcag  gtgttagcc  aagatctga  actcgactt  aaagatata  6300
agaggccag  gtcagaaca  ggtttatcc  ccgattcag  aaatttcga  tggaaagct  6360
ttcaggaag  tgcaaactc  atagtaagt  gtctgcacc  agctgccgc  gccgccgcg  6420
gtctgtcca  acaagcgtc  tcggactca  actccatcc  gtccctgaa  tcgggcgtc  6480
ccctggggt  gccttttca  cttacacct  accaagagg  gaagccatt  acaagtcat  6540
aaggcccaa  aattctcaa  cctggggag  aaagcacat  agaagcaaa  aaaatagaa  6600
ccgaaaaca  aggaatcaa  ggtggaaaa  aggtttata  aagcttgat  acaggaaag  6660
ttcgatcta  ttcagaaat  tccagccaa  tgaaacaac  ccttcagac  aacatgcct  6720
caatctcaa  aggcaggac  atgattcac  tcccgggag  tcggaacag  tcctcaagt  6780
caagccctg  ctctaaaaa  ggcccaccc  tcaagactc  agcctctaa  agccccagt  6840
aaggtcctg  agctaccac  tctcctcgt  gaactaagc  agcagtgaa  tcagagctg  6900
gccctatta  caggcaaac  tcccacatt  gtgggtcaa  taaggggcc  tctaggtca  6960
ggtctagag  ctccactcc  tcgagaccc  cacagcagc  attaagtag  ccgatgcag  7020
cgccagggc  gaactcgat  tcccccggt  gaaatggaa  aagcactcc  aacaaactc  7080
ctcagctgc  cagaacatc  tctcccagt  ctgcttcga  caagtcctc  gggtcgggg  7140
aaatgtcct  cacatcccc  ggccggcag  tgagccagc  aaacctcag  aaacaaaca  7200
gcttgtcca  gaacgccag  agcatcccc  gaagtgagt  agcatccaa  ggactgaat  7260
agatgaata  cagcaatgg  tctaataaa  aggtagaac  ttctagaat  tcttcaact  7320
agtcaagtg  aagtgaatc  gacaggtca  aaagacctg  attagtacg  cagtccact  7380
tcatcaaag  agccccaag  ccaacccta  ggaggaaac  ggaggaatc  gcctcattt  7440
aatcccttt  tccatcttc  agaccagat  ctcccacca  gtcccaggc  cagacccca  7500
ttttaagcc  ttcccttcc  gatatgtct  tgtccacac  tccatctgt  caggcaggt  7560
gatggcgca  gctcccacc  aacctcagc  ccactatag  gtacagtga  ggaaggccc  7620
caaagcggc  tgatatcgc  cgctcccat  ctgaaagtc  gtccagact  ccagtcaac  7680
gagcgggaa  ctggaagcg  gaacacagc  aacattcct  atcccttcc  cgagtgagc  7740
cttggagaa  aactggaag  tcatcttct  ttctttctg  ttcttcaga  tccagtgaa  7800
aagcaaaaa  tgaggatga  aagcatgtg  actctgtgc  aggacccag  caaatgaaa  7860
aaaaccagg  acccacaaa  ggaacatgg  ggaaaataa  ggaaagtga  atttctccc  7920
caaacacgg  ttctcagac  acttcctca  gtgctgcca  tggtgctga  tcaaagact  7980
tgatctatc  gatggcacc  gctgtttct  gaacagagg  cgtttgggt  agaattgag  8040
actgcccca  taacaaccc  agatctgga  gatctccca  aggtaacac  cccccagtg  8100
ttgacagca  ttcagaaaa  ggaaatcca  gcattaaag  ttcaaaaga  acccaagga  8160
aacaaagtg  gggcagtgg  agtcctgtg  aaaccgtgg  tctagaaaa  cgcctgaac  8220
cctttattc  ggtagaggc  ccggaacag  aaggaactg  gactaaagc  ggacagggt  8280
gccctgccc  tgtagcaga  actggtgag  cctgcatgg  agagcgcac  cctttcagt  8340
caagtagct  cagcaagca  agttctccc  gtgggacgg  cgctgccag  gtgacgcct  8400
ttaattaca  cccaagccc  aggaaaagc  gcgcagaca  cacttcagc  cggccatct  8460
agatcccca  tccggtggg  agcagcaca  agaagagag  ctcgaagac  gacagcact  8520
aatctagtg  agcccagag  cctaaacgc  attctgggt  ttacctcgt  acgtctgtt  8580
aa  8582



<210> 2024
<211> 2842
<212> PRT
<213> Rattus norvegicus
<308> P70478
<400> 2024

Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu 
  1               5                  10                  15
Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn 
             20                  25                  30
His Leu Thr Glu Leu Glu Thr Glu Ala Ser Asn Met Lys Glu Val Leu 
         35                  40                  45
Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Thr Met Thr Ser Gly Gln 
     50                  55                  60
Ile Asp Leu Leu Glu Arg Leu Lys Glu Phe Asn Leu Asp Ser Asn Phe 
 65                  70                  75                  80
Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr Gly Ser 
                 85                  90                  95
Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro Val Pro 
             100                105                110
Met Gly Ser Phe Pro Arg Arg Ala Phe Val Asn Gly Ser Arg Glu Ser 
         115                120                125
Thr Gly Tyr Leu Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu Leu Ala 
     130                135                140
Asp Leu Asp Lys Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala Gln Leu 
 145                150                155                160
Gln Asn Leu Thr Lys Arg Ile Asp Ser Leu Pro Leu Thr Glu Asn Phe 
                 165                170                175
Ser Leu Gln Thr Asp Met Thr Arg Arg Gln Leu Glu Tyr Glu Ala Arg 
             180                185                190
Gln Ile Arg Ala Ala Met Glu Glu Gln Leu Gly Thr Cys Gln Asp Met 
         195                200                205
Glu Lys Arg Ala Gln Arg Arg Ile Ala Arg Ile Gln Gln Ile Glu Lys 
     210                215                220
Asp Ile Leu Arg Val Arg Gln Leu Leu Gln Ser Gln Ala Ala Glu Ala 
 225                230                235                240
Glu Arg Ser Ser Gln Ser Lys His Glu Thr Ala Ser His Glu Ala Glu 
                 245                250                255
Arg Gln Leu Glu Gly Gln Gly Val Ala Glu Ser Asn Leu Ala Thr Ser 
             260                265                270
Gly Ser Gly Gln Ser Ser Ala Ala Arg Val Asp His Glu Thr Ala Gly 
         275                280                285
Val Leu Ser Ser Ser Gly Thr His Ser Ala Pro Arg Arg Leu Thr Ser 
     290                295                300
His Leu Gly Thr Lys Val Glu Met Val Tyr Ser Leu Leu Ser Met Leu 
 305                310                315                320
Gly Thr His Asp Lys Asp Asp Met Ser Arg Thr Leu Leu Ala Met Ser 
                 325                330                335
Ser Ser Gln Asp Ser Cys Ile Ser Met Arg Gln Ser Gly Cys Leu Pro 
             340                345                350
Leu Leu Ile Gln Leu Leu His Gly Asn Asp Lys Asp Ser Val Leu Leu 
         355                360                365
Gly Asn Ser Arg Gly Ser Lys Glu Ala Arg Ala Arg Ala Ser Ala Ala 
     370                375                380
Leu His Asn Ile Ile His Ser Gln Pro Asp Asp Lys Arg Gly Arg Arg 
 385                390                395                400
Glu Ile Arg Val Leu His Leu Leu Glu Gln Ile Arg Ala Tyr Cys Glu 
                 405                410                415
Thr Cys Trp Glu Trp Gln Glu Ala His Glu Gln Gly Met Asp Gln Asp 
             420                425                430
Lys Asn Pro Met Pro Ala Pro Val Glu His Gln Ile Cys Pro Ala Val 
         435                440                445
Cys Val Leu Met Lys Leu Ser Phe Asp Glu Glu His Arg His Ala Met 
     450                455                460
Asn Glu Leu Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln Val Asp 
 465                470                475                480
Cys Glu Met His Gly Leu Thr Asp Asp His Tyr Ser Val Thr Leu Arg 
                 485                490                495
Arg Tyr Ala Gly Met Ala Leu Thr Asn Leu Thr Phe Gly Asp Val Ala 
             500                505                510
Asn Lys Ala Thr Leu Cys Ser Met Lys Gly Cys Met Arg Ala Leu Val 
         515                520                525
Ala Gln Leu Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile Ala Ser 
     530                535                540
Val Leu Arg Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys Lys Thr 
 545                550                555                560
Leu Arg Glu Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala Leu Glu 
                 565                570                575
Val Lys Lys Glu Ser Thr Leu Lys Ser Val Leu Ser Ala Leu Trp Asn 
             580                585                590
Leu Ser Ala His Cys Thr Glu Asn Lys Ala Asp Ile Cys Ala Val Asp 
         595                600                605
Gly Ala Leu Ala Phe Leu Val Gly Thr Leu Thr Tyr Arg Ser Gln Thr 
     610                615                620
Asn Thr Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg Asn Val 
 625                630                635                640
Ser Ser Leu Ile Ala Thr Asn Glu Asp His Arg Gln Ile Leu Arg Glu 
                 645                650                655
Asn Asn Cys Leu Gln Thr Leu Leu Gln His Leu Lys Ser His Ser Leu 
             660                665                670
Thr Ile Val Ser Asn Ala Cys Gly Thr Leu Trp Asn Leu Ser Ala Arg 
         675                680                685
Asn Pro Lys Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val Ser Met 
     690                695                700
Leu Lys Asn Leu Ile His Ser Lys His Lys Met Ile Ala Met Gly Ser 
 705                710                715                720
Ala Ala Ala Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys Tyr Lys 
                 725                730                735
Asp Ala Asn Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu His Val 
             740                745                750
Arg Lys Gln Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His Leu Ser 
         755                760                765
Glu Thr Phe Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser His Arg 
     770                775                780
Ser Lys Gln Arg His Lys Gln Asn Leu Tyr Gly Asp Tyr Val Phe Asp 
 785                790                795                800
Ala Ser Arg His Asp Asp Asn Arg Ser Asp Asn Phe Asn Thr Gly Asn 
                 805                810                815
Met Thr Val Leu Ser Pro Tyr Leu Asn Thr Thr Val Leu Pro Ser Ser 
             820                825                830
Ser Ser Ser Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys Asp Arg 
         835                840                845
Ser Leu Glu Arg Glu Arg Gly Ile Gly Leu Ser Thr Tyr His Ser Ala 
     850                855                860
Thr Glu Asn Pro Gly Thr Ser Ser Lys Arg Gly Leu Gln Leu Ser Ala 
 865                870                875                880
Thr Ala Ala Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala Leu His 
                 885                890                895
Thr Ser Gln Asp Asp Arg Ser Pro Ala Ser Ala Ala Glu Leu His Cys 
             900                905                910
Val Ala Glu Glu Arg Thr Ala Ala Arg Arg Ser Ser Ala Ser His Thr 
         915                920                925
His Pro Asn Thr His Asn Phe Ala Lys Ser Glu Ser Ser Asn Arg Thr 
     930                935                940
Cys Ser Met Pro Tyr Ala Lys Val Glu Tyr Lys Arg Ser Ser Asn Asp 
 945                950                955                960
Ser Leu Asn Ser Val Thr Ser Ser Asp Gly Tyr Gly Lys Arg Gly Gln 
                 965                970                975
Met Lys Pro Ser Val Glu Ser Tyr Ser Glu Asp Asp Glu Gly Lys Phe 
             980                985                990
Cys Ser Tyr Gly Gln Tyr Pro Ala Asp Leu Ala His Lys Ile His Ser 
         995                1000                1005
Ala Asn His Met Asp Asp Asn Gly Gly Glu Leu Asp Thr Pro Ile Asn 
     1010                1015                1020
Tyr Ser Leu Lys Tyr Ser Asp Glu Gln Leu Asn Ser Gly Arg Gln Ser 
 1025                1030                1035                1040
Pro Ser Gln Asn Glu Arg Trp Ala Arg Pro Lys His Val Ile Glu Asp 
                 1045                1050                1055
Glu Ile Lys Gln Asn Glu Gln Arg Gln Ser Arg Ser Gln Asn Thr Asn 
             1060                1065                1070
Phe Pro Val Tyr Ser Glu Asn Thr Asp Asp Lys His Leu Lys Phe Gln 
         1075                1080                1085
Gln His Phe Gly Gln Gln Glu Cys Val Ser Pro Tyr Arg Ser Arg Gly 
     1090                1095                1100
Thr Asn Gly Ser Glu Thr Asn Arg Met Gly Ser Ser His Ala Val Asn 
 1105                1110                1115                1120
Gln Asn Val Asn Gln Ser Leu Cys Gln Glu Asp Asp Tyr Glu Asp Asp 
                 1125                1130                1135
Lys Pro Thr Asn Tyr Ser Glu Arg Tyr Ser Glu Glu Glu Gln His Glu 
             1140                1145                1150
Glu Glu Glu Arg Pro Thr Asn Tyr Ser Ile Lys Tyr Asn Glu Glu Lys 
         1155                1160                1165
His His Val Asp Gln Pro Ile Asp Tyr Ser Leu Lys Tyr Ala Thr Asp 
     1170                1175                1180
Ile Ser Ser Ser Gln Lys Pro Ser Phe Ser Phe Ser Lys Thr Pro Ser 
 1185                1190                1195                1200
Val Gln Gly Thr Lys Thr Glu His Asn Ser Pro Ser Ser Glu Ala Ala 
                 1205                1210                1215
Ser Ala Pro Ser Ser Asn Ala Lys Arg Gln Ser Gln Leu His Pro Ser 
             1220                1225                1230
Ser Ala Gln Arg Asn Gly Gln Thr Pro Lys Gly Thr Ala Cys Lys Val 
         1235                1240                1245
Pro Ser Ile Asn Gln Glu Thr Met Gln Thr Tyr Cys Val Glu Asp Thr 
     1250                1255                1260
Pro Ile Cys Phe Ser Arg Cys Ser Ser Leu Ser Ser Leu Ser Ser Ala 
 1265                1270                1275                1280
Glu Asp Glu Ile Gly Cys Asp Gln Thr Thr Gln Glu Ala Asp Ser Ala 
                 1285                1290                1295
Asn Thr Leu Gln Ile Ala Glu Ile Lys Glu Asn Asp Val Thr Arg Ser 
             1300                1305                1310
Ala Gln Asp Pro Ala Ser Asp Val Pro Ala Val Ser Gln Ser Thr Arg 
         1315                1320                1325
Thr Lys Pro Ser Arg Leu Gln Ala Ser Gly Leu Ala Ser Glu Ser Ala 
     1330                1335                1340
Arg His Lys Ala Val Glu Phe Ser Ser Gly Ala Lys Ser Pro Ser Lys 
 1345                1350                1355                1360
Ser Gly Ala Gln Thr Pro Lys Ser Pro Pro Glu His Tyr Val Gln Glu 
                 1365                1370                1375
Thr Pro Leu Val Phe Ser Arg Cys Thr Ser Val Ser Ser Leu Asp Ser 
             1380                1385                1390
Phe Glu Ser Arg Ser Ile Ala Ser Ser Val Gln Ser Glu Pro Cys Ser 
         1395                1400                1405
Gly Met Val Ser Gly Ile Val Ser Pro Ser Asp Leu Pro Asp Ser Pro 
     1410                1415                1420
Gly Gln Thr Met Pro Pro Ser Arg Ser Lys Thr Pro Pro Pro Pro Pro 
 1425                1430                1435                1440
Pro Pro Gln Pro Val Gln Thr Lys Arg Glu Val Pro Lys Thr Lys Val 
                 1445                1450                1455
Pro Ala Ala Glu Gln Arg Glu Gly Gly Pro Lys Gln Thr Ala Val Ser 
             1460                1465                1470
Ala Ala Val Gln Arg Val Gln Val Leu Pro Asp Ala Asp Thr Leu Leu 
         1475                1480                1485
His Phe Ala Thr Glu Ser Thr Pro Asp Gly Phe Ser Cys Ser Ser Ser 
     1490                1495                1500
Leu Ser Ala Leu Ser Leu Asp Glu Pro Phe Ile Gln Lys Asp Val Glu 
 1505                1510                1515                1520
Leu Arg Ile Met Pro Pro Val Gln Glu Asn Asp Asn Gly Asn Glu Thr 
                 1525                1530                1535
Glu Pro Glu Gln Pro Glu Glu Ser Asn Glu Asn Gln Asp Lys Glu Val 
             1540                1545                1550
Glu Lys Pro Asp Ser Glu Lys Asp Leu Leu Asp Asp Ser Asp Asp Asp 
         1555                1560                1565
Asp Ile Glu Ile Leu Glu Glu Cys Ile Ile Ser Ala Met Pro Thr Lys 
     1570                1575                1580
Ser Ser Arg Lys Ala Lys Lys Leu Ala Gln Thr Ala Ser Lys Leu Pro 
 1585                1590                1595                1600
Pro Pro Val Ala Arg Lys Pro Ser Gln Leu Pro Val Tyr Lys Leu Leu 
                 1605                1610                1615
Pro Ser Gln Ser Arg Leu Gln Ala Gln Lys His Val Ser Phe Thr Pro 
             1620                1625                1630
Gly Asp Asp Val Pro Arg Val Tyr Cys Val Glu Gly Thr Pro Ile Asn 
         1635                1640                1645
Phe Ser Thr Ala Thr Ser Leu Ser Asp Leu Thr Ile Glu Ser Pro Pro 
     1650                1655                1660
Asn Glu Leu Ala Ala Gly Asp Gly Val Arg Ala Ser Val Gln Ser Gly 
 1665                1670                1675                1680
Glu Phe Glu Lys Arg Asp Thr Ile Pro Thr Glu Gly Arg Ser Thr Asp 
                 1685                1690                1695
Glu Ala Gln Arg Gly Lys Val Ser Ser Ile Ala Ile Pro Asp Leu Asp 
             1700                1705                1710
Gly Ser Lys Ala Glu Glu Gly Asp Ile Leu Ala Glu Cys Ile Asn Ser 
         1715                1720                1725
Ala Leu Pro Lys Gly Arg Ser His Lys Pro Phe Arg Val Lys Lys Ile 
     1730                1735                1740
Met Asp Gln Val Gln Gln Ala Ser Met Thr Ser Ser Gly Thr Asn Lys 
 1745                1750                1755                1760
Asn Gln Ile Asp Thr Lys Lys Lys Lys Pro Thr Ser Pro Val Lys Pro 
                 1765                1770                1775
Met Pro Gln Asn Thr Glu Tyr Arg Thr Arg Val Arg Lys Asn Thr Asp 
             1780                1785                1790
Ser Lys Val Asn Val Asn Thr Glu Glu Thr Phe Ser Asp Asn Lys Asp 
         1795                1800                1805
Ser Lys Lys Gln Ser Leu Lys Asn Asn Pro Lys Asp Leu Asn Asp Lys 
     1810                1815                1820
Leu Pro Asp Asn Glu Asp Arg Val Arg Gly Gly Phe Thr Phe Asp Ser 
 1825                1830                1835                1840
Pro His His Tyr Ala Pro Ile Glu Gly Thr Pro Tyr Cys Phe Ser Arg 
                 1845                1850                1855
Asn Asp Ser Leu Ser Ser Leu Asp Phe Asp Asp Asp Asp Val Asp Leu 
             1860                1865                1870
Ser Arg Glu Lys Ala Glu Leu Arg Lys Gly Lys Glu Ser Lys Asp Ser 
         1875                1880                1885
Glu Ala Lys Val Thr Cys His Thr Glu Pro Ser Ser Ser Gln Gln Ser 
     1890                1895                1900
Ala Arg Lys Ala Gln Ala Ser Thr Lys His Pro Val Asn Arg Gly Pro 
 1905                1910                1915                1920
Ser Lys Pro Leu Leu Gln Glu Gln Pro Thr Phe Pro Gln Ser Ser Lys 
                 1925                1930                1935
Asp Val Pro Asp Arg Gly Ala Ala Thr Asp Glu Lys Leu Gln Asn Phe 
             1940                1945                1950
Ala Ile Glu Asn Thr Pro Val Cys Phe Ser Arg Asn Ser Ser Leu Ser 
         1955                1960                1965
Ser Leu Ser Asp Val Asp Gln Glu Asn Asn Asn Asn Glu Glu Thr Gly 
     1970                1975                1980
Pro Val Arg Asp Ala Glu Pro Ala Asn Ala Gln Gly Gln Pro Gly Lys 
 1985                1990                1995                2000
Pro Gln Ala Ser Gly Tyr Ala Pro Lys Ser Phe His Val Glu Asp Thr 
                 2005                2010                2015
Pro Val Cys Phe Ser Arg Asn Ser Ser Leu Ser Ser Leu Ser Ile Asp 
             2020                2025                2030
Ser Glu Asp Asp Leu Leu Arg Glu Cys Ile Ser Ser Ala Met Pro Lys 
         2035                2040                2045
Lys Arg Arg Pro Ser Arg Leu Lys Gly Glu Gly Glu Trp Gln Ser Pro 
     2050                2055                2060
Arg Lys Val Gly Ser Val Leu Ala Glu Asp Leu Thr Leu Asp Leu Lys 
 2065                2070                2075                2080
Asp Ile Gln Arg Pro Glu Ser Glu His Gly Leu Ser Pro Asp Ser Glu 
                 2085                2090                2095
Asn Phe Asp Trp Lys Ala Ile Gln Glu Gly Ala Asn Ser Ile Val Ser 
             2100                2105                2110
Ser Leu His Gln Ala Ala Ala Ala Ala Ala Cys Leu Ser Arg Gln Ala 
         2115                2120                2125
Ser Ser Asp Ser Asp Ser Ile Leu Ser Leu Lys Ser Gly Val Ser Leu 
     2130                2135                2140
Gly Ser Pro Phe His Leu Thr Pro Asp Gln Glu Glu Lys Pro Phe Thr 
 2145                2150                2155                2160
Ser His Lys Gly Pro Arg Ile Leu Lys Pro Gly Glu Lys Ser Thr Leu 
                 2165                2170                2175
Glu Ala Lys Lys Ile Glu Ser Glu Asn Lys Gly Ile Lys Gly Gly Lys 
             2180                2185                2190
Lys Val Tyr Lys Ser Leu Ile Thr Gly Lys Ile Arg Ser Asn Ser Glu 
         2195                2200                2205
Ile Ser Ser Gln Met Lys Gln Pro Leu Gln Thr Asn Met Pro Ser Ile 
     2210                2215                2220
Ser Arg Gly Arg Thr Met Ile His Ile Pro Gly Val Arg Asn Ser Ser 
 2225                2230                2235                2240
Ser Ser Thr Ser Pro Val Ser Lys Lys Gly Pro Pro Leu Lys Thr Pro 
                 2245                2250                2255
Ala Ser Lys Ser Pro Ser Glu Gly Pro Val Ala Thr Thr Ser Pro Arg 
             2260                2265                2270
Gly Thr Lys Pro Ala Val Lys Ser Glu Leu Ser Pro Ile Thr Arg Gln 
         2275                2280                2285
Thr Ser His Ile Ser Gly Ser Asn Lys Gly Pro Ser Arg Ser Gly Ser 
     2290                2295                2300
Arg Asp Ser Thr Pro Ser Arg Pro Thr Gln Gln Pro Leu Ser Arg Pro 
 2305                2310                2315                2320
Met Gln Ser Pro Gly Arg Asn Ser Ile Ser Pro Gly Arg Asn Gly Ile 
                 2325                2330                2335
Ser Thr Pro Asn Lys Leu Ser Gln Leu Pro Arg Thr Ser Ser Pro Ser 
             2340                2345                2350
Thr Ala Ser Thr Lys Ser Ser Gly Ser Gly Lys Met Ser Tyr Thr Ser 
         2355                2360                2365
Pro Gly Arg Gln Leu Ser Gln Gln Asn Leu Ser Lys Gln Thr Gly Leu 
     2370                2375                2380
Ser Lys Asn Ala Ser Ser Ile Pro Arg Ser Glu Ser Ala Ser Lys Gly 
 2385                2390                2395                2400
Leu Asn Gln Met Asn Asn Ser Asn Gly Ser Asn Lys Lys Val Glu Leu 
                 2405                2410                2415
Ser Arg Met Ser Ser Thr Lys Ser Ser Gly Ser Glu Ser Asp Arg Ser 
             2420                2425                2430
Glu Arg Pro Ala Leu Val Arg Gln Ser Thr Phe Ile Lys Glu Ala Pro 
         2435                2440                2445
Ser Pro Thr Leu Arg Arg Lys Leu Glu Glu Ser Ala Ser Phe Glu Ser 
     2450                2455                2460
Leu Ser Pro Ser Ser Arg Pro Asp Ser Pro Thr Arg Ser Gln Ala Gln 
 2465                2470                2475                2480
Thr Pro Val Leu Ser Pro Ser Leu Pro Asp Met Ser Leu Ser Thr His 
                 2485                2490                2495
Pro Ser Val Gln Ala Gly Gly Trp Arg Lys Leu Pro Pro Asn Leu Ser 
             2500                2505                2510
Pro Thr Ile Glu Tyr Ser Asp Gly Arg Pro Ser Lys Arg His Asp Ile 
         2515                2520                2525
Ala Arg Ser His Ser Glu Ser Pro Ser Arg Leu Pro Val Asn Arg Ala 
     2530                2535                2540
Gly Thr Trp Lys Arg Glu His Ser Lys His Ser Ser Ser Leu Pro Arg 
 2545                2550                2555                2560
Val Ser Thr Trp Arg Arg Thr Gly Ser Ser Ser Ser Ile Leu Ser Ala 
                 2565                2570                2575
Ser Ser Glu Ser Ser Glu Lys Ala Lys Ser Glu Asp Glu Lys His Val 
             2580                2585                2590
Asn Ser Val Pro Gly Pro Arg Gln Met Lys Glu Asn Gln Val Pro Thr 
         2595                2600                2605
Lys Gly Thr Trp Arg Lys Ile Lys Glu Ser Glu Ile Ser Pro Thr Asn 
     2610                2615                2620
Thr Val Ser Gln Thr Thr Ser Ser Gly Ala Ala Ser Gly Ala Glu Ser 
 2625                2630                2635                2640
Lys Thr Leu Ile Tyr Gln Met Ala Pro Ala Val Ser Arg Thr Glu Asp 
                 2645                2650                2655
Val Trp Val Arg Ile Glu Asp Cys Pro Ile Asn Asn Pro Arg Ser Gly 
             2660                2665                2670
Arg Ser Pro Thr Gly Asn Thr Pro Pro Val Ile Asp Ser Ile Ser Glu 
         2675                2680                2685
Lys Gly Asn Pro Ser Ile Lys Asp Ser Lys Asp Thr Gln Gly Lys Gln 
     2690                2695                2700
Ser Val Gly Ser Gly Ser Pro Val Gln Thr Val Gly Leu Glu Asn Arg 
 2705                2710                2715                2720
Leu Asn Ser Phe Ile Gln Val Glu Ala Pro Glu Gln Lys Gly Thr Glu 
                 2725                2730                2735
Thr Lys Ala Gly Gln Gly Ser Pro Ala Pro Val Ala Glu Thr Gly Glu 
             2740                2745                2750
Thr Cys Met Ala Glu Arg Thr Pro Phe Ser Ser Ser Ser Ser Ser Lys 
         2755                2760                2765
His Ser Ser Pro Ser Gly Thr Val Ala Ala Arg Val Thr Pro Phe Asn 
     2770                2775                2780
Tyr Asn Pro Ser Pro Arg Lys Ser Ser Ala Asp Ser Thr Ser Ala Arg 
 2785                2790                2795                2800
Pro Ser Gln Ile Pro Thr Pro Val Gly Ser Ser Thr Lys Lys Arg Asp 
                 2805                2810                2815
Ser Lys Thr Asp Ser Thr Glu Ser Ser Gly Ala Gln Ser Pro Lys Arg 
             2820                2825                2830
His Ser Gly Ser Tyr Leu Val Thr Ser Val 
         2835                2840



<210> 2025
<211> 1272
<212> DNA
<213> Rattus norvegicus
<308> D42116
<400> 2025

cctcattgg  tcctcctct  ctatgtgca  aatctctga  cagagcgtt  cctgggatg  60
cgaggcacc  atttgtgaa  caattcctt  tgagatacc  ccaagcatt  ccaatggag  120
tttcttcag  cctaacaga  aagattttc  ttatggaat  gtagttacc  accagtgca  180
cactgatgc  agagggaag  agctcttta  cctggtggg  gagccctcc  tacactgta  240
cagcatcga  ggtcaagtt  gagtctgga  tggccctcc  cctcagtgc  ttgaactca  300
caaatgtac  cctccccat  ttgaaaatg  agtcatagt  tctaaaaac  aaagcttgt  360
ttccttaag  gatatggtg  agtttagat  tcaggatgg  tttatgatg  aaggagaca  420
cagtgtgta  tgtcgatcc  taaacagat  ggagcctca  ttaccaagc  gcttcaagg  480
gaaatcctg  ggtgctttc  tgggtgagc  tcctaatgg  catgtattc  ttccacaaa  540
tcttcaact  ggggccaaa  tgacctttg  ttgtaatac  gggtatcaa  taaaaggca  600
ttcttctag  cattgtgtt  ttgatggag  ggaaagcat  tggaatagc  gcgttcctg  660
gtgtgaaca  gtgatatgt  aactccctc  ggatatgag  ggattccag  aagggttgc  720
aatgaaaaa  gattattac  atggagata  tgtagcctt  gaatgtgag  atgggtata  780
tctagaagg  agttctcag  gccagtgcc  gtccgatgc  agctgggat  ctcctctgc  840
caaatgtgt  tctcaagtg  tatgtaaac  ccctcagga  atgagtgga  tccagaaag  900
gttgcaaat  aaaaaagat  attactatg  agataatgt  gccttggaa  gtgaggatg  960
gtatactct  gaaggcagt  ctcagagcc  gtgccagtc  gatgccagc  gggatcctc  1020
tctgcccaa  tgtgtctct  aagtgatat  taaactccc  caggatatg  gtggattcc  1080
gaaagggtt  caaatgaaa  aagattatt  ctatggaga  aatgtagcc  tggaatgtg  1140
ggatgggta  actctagaa  gcagttctc  gagccagtg  cagtccgat  ccagctggg  1200
tcctcctct  cccaaatgt  tctctcgct  aaacagtgg  ctaatagct  gaattttca  1260
tgggataat  gt  1272



<210> 2026
<211> 559
<212> PRT
<213> Rattus norvegicus
<308> BAA22548
<400> 2026

Met Glu Ala Ser Ser Pro Leu Asp Pro Val Gly Arg Leu Val Ala Phe 
  1               5                  10                  15
Cys Arg Gly Gly Val His Leu Ala Val Leu Leu Leu Phe Leu Ser Pro 
             20                  25                  30
Ser Thr Leu Gly Gln Cys Pro Ala Pro Pro Leu Phe Pro Tyr Ala Lys 
         35                  40                  45
Pro Ile Asn Pro Thr Asp Glu Ser Thr Phe Pro Val Gly Thr Ser Leu 
     50                  55                  60
Lys Tyr Glu Cys Arg Pro Gly Tyr Ile Lys Arg Gln Phe Ser Ile Thr 
 65                  70                  75                  80
Cys Glu Val Asn Ser Val Trp Thr Ser Pro Gln Asp Val Cys Ile Arg 
                 85                  90                  95
Lys Gln Cys Glu Thr Pro Leu Asp Pro Gln Asn Gly Ile Val His Val 
             100                105                110
Asn Thr Asp Ile Arg Phe Gly Ser Ser Ile Thr Tyr Thr Cys Asn Glu 
         115                120                125
Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Met Cys Ile Ile Ser Asp 
     130                135                140
Gln Ser Val Ala Trp Asp Ala Glu Ala Pro Ile Cys Glu Ser Ile Pro 
 145                150                155                160
Cys Glu Ile Pro Pro Ser Ile Pro Asn Gly Asp Phe Phe Ser Pro Asn 
                 165                170                175
Arg Glu Asp Phe His Tyr Gly Met Val Val Thr Tyr Gln Cys Asn Thr 
             180                185                190
Asp Ala Arg Gly Lys Lys Leu Phe Asn Leu Val Gly Glu Pro Ser Ile 
         195                200                205
His Cys Thr Ser Ile Asp Gly Gln Val Gly Val Trp Ser Gly Pro Pro 
     210                215                220
Pro Gln Cys Ile Glu Leu Asn Lys Cys Thr Pro Pro His Val Glu Asn 
 225                230                235                240
Ala Val Ile Val Ser Lys Asn Lys Ser Leu Phe Ser Leu Arg Asp Met 
                 245                250                255
Val Glu Phe Arg Cys Gln Asp Gly Phe Met Met Lys Gly Asp Ser Ser 
             260                265                270
Val Tyr Cys Arg Ser Leu Asn Arg Trp Glu Pro Gln Leu Pro Ser Cys 
         275                280                285
Phe Lys Val Lys Ser Cys Gly Ala Phe Leu Gly Glu Leu Pro Asn Gly 
     290                295                300
His Val Phe Val Pro Gln Asn Leu Gln Leu Gly Ala Lys Val Thr Phe 
 305                310                315                320
Val Cys Asn Thr Gly Tyr Gln Leu Lys Gly Asn Ser Ser Ser His Cys 
                 325                330                335
Val Leu Asp Gly Val Glu Ser Ile Trp Asn Ser Ser Val Pro Val Cys 
             340                345                350
Glu Gln Val Ile Cys Lys Leu Pro Gln Asp Met Ser Gly Phe Gln Lys 
         355                360                365
Gly Leu Gln Met Lys Lys Asp Tyr Tyr Tyr Gly Asp Asn Val Ala Leu 
     370                375                380
Glu Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Ser Gln Ser Gln Cys 
 385                390                395                400
Gln Ser Asp Ala Ser Trp Asp Pro Pro Leu Pro Lys Cys Val Ser Gln 
                 405                410                415
Val Ile Cys Lys Leu Pro Gln Asp Met Ser Gly Phe Gln Lys Gly Leu 
             420                425                430
Gln Met Lys Lys Asp Tyr Tyr Tyr Gly Asp Asn Val Ala Leu Glu Cys 
         435                440                445
Glu Asp Gly Tyr Thr Leu Glu Gly Ser Ser Gln Ser Gln Cys Gln Ser 
     450                455                460
Asp Ala Ser Trp Asp Pro Pro Leu Pro Lys Cys Val Ser Arg Ser Asn 
 465                470                475                480
Ser Gly Leu Ile Ala Gly Ile Phe Ile Gly Ile Ile Val Leu Ile Leu 
                 485                490                495
Phe Ile Ile Phe Ser Tyr Trp Met Ile Met Lys Phe Lys Lys Arg Asn 
             500                505                510
Ser Thr Asn Glu Lys Cys Lys Glu Val Gly Ile Tyr Leu Asn Ser Lys 
         515                520                525
Glu Asp Ser Cys Val Gln Pro Gln Ser Leu Leu Thr Ser Gln Glu Asn 
     530                535                540
Asn Ser Thr Ser Ser Pro Ala Arg Asn Ser Leu Thr Gln Glu Val 
 545                550                555



<210> 2027
<211> 5420
<212> DNA
<213> Homo sapiens
<308> X05309
<400> 2027

ccaagttga  aacccaaac  aatgcatct  actttccca  tgggacatc  ttaaagtac  60
aatgccgtc  tgagtacta  gggaggcca  tctctatca  atgtctaga  aacctggtc  120
ggtcaagtc  caaagatgt  tgtaaacgt  aatcatgta  aactcctcc  gatccagtg  180
atggcatgg  gcatgtgat  acagacatc  aggttggat  cagaatcaa  tattcttgt  240
ctacagggc  ccgactcat  ggtcactca  ctgctgaat  tatcctctc  ggcaatgct  300
cccattgga  cacgaagcc  ccaatttgt  aacgaattc  ttgtgggct  ccccccacc  360
tcgccaatg  agatttcat  agcaccaac  gagagaatt  tcactatgg  tcagtggtg  420
cctaccgct  caatcctgg  agcggaggg  gaaaggtgt  tgagcttgt  ggtgagccc  480
ccatatact  caccagcaa  gacgatcaa  tgggcatct  gagcggccc  gcccctcag  540
gcattatac  taacaaatg  acgcctcca  atgtggaaa  tggaatatt  gtatctgac  600
acagaagct  attttcctt  aatgaagtt  tggagttta  gtgtcagcc  ggctttgtc  660
tgaaaggac  ccgccgtgt  aagtgccag  ccctgaaca  atgggagcc  gagctacca  720
gctgctcca  ggtatgtca  ccacctcca  atgtcctgc  tgctgagcg  acccaaagg  780
acaaggaca  cttttcacc  gggcaggaa  tgttctaca  ctgtgagcc  ggctatgac  840
tcagagggg  tgcgtctat  cgctgcaca  cccagggag  ctggagccc  gcagccccc  900
catgtgaag  gaaatcctg  gatgacttc  tgggccaac  tcttaatgg  cgtgtgcta  960
ttccagtaa  tctccagct  ggagcaaaa  tggattttg  ttgtgatga  ggatttcaa  1020
taaaaggca  ctctgctag  tattgtgtc  tggctggaa  ggaaagcct  tggaatagc  1080
gtgttccag  gtgtgaaca  atcttttgt  caagtcctc  agttattcc  aatgggaga  1140
acacaggaa  acctctgga  gtctttccc  ttggaaaag  agtaaatta  acatgcgac  1200
cccacccag  cagagggac  agcttcgac  tcattggag  gagcaccat  cgctgcaca  1260
gtgaccctc  agggaatgg  gtttggagc  gccctgccc  tcgctgtgg  attctgggt  1320
actgtcaag  cccagatca  tttctgttt  ccaagttga  aacccaaac  aatgcatct  1380
actttccca  tgggacatc  ttaaagtac  aatgccgtc  tgagtacta  gggaggcca  1440
tctctatca  atgtctaga  aacctggtc  ggtcaagtc  caaagatgt  tgtaaacgt  1500
aatcatgta  aactcctcc  gatccagtg  atggcatgg  gcatgtgat  acagacatc  1560
aggttggat  cagaatcaa  tattcttgt  ctacagggc  ccgactcat  ggtcactca  1620
ctgctgaat  tatcctctc  ggcaatact  cccattgga  cacgaagcc  ccaatttgt  1680
aacgaattc  ttgtgggct  cccccaacc  tcgccaatg  agatttcat  agcaccaac  1740
gagagaatt  tcactatgg  tcagtggtg  cctaccgct  caatcttgg  agcagaggg  1800
gaaaggtgt  tgagcttgt  ggtgagccc  ccatatact  caccagcaa  gacgatcaa  1860
tgggcatct  gagcggccc  gcccctcag  gcattatac  taacaaatg  acgcctcca  1920
atgtggaaa  tggaatatt  gtatctgac  acagaagct  attttcctt  aatgaagtt  1980
tggagttta  gtgtcagcc  ggctttgtc  tgaaaggac  ccgccgtgt  aagtgccag  2040
ccctgaaca  atgggagcc  gagttacca  gctgctcca  ggtgtgtca  ccgcctcca  2100
aaatcctgc  tggtgagca  accccaagc  atcaggaca  cttttcacc  gggcaggaa  2160
tgttctaca  ctgtgagcc  ggctatgac  tcagagggg  tgcgtctct  cactgcaca  2220
cccagggag  ctggagccc  gaagccccg  gatgtgcag  gaaatcctg  gatgacttc  2280
tgggtcaac  ccctcatgg  cgtgtgcta  ttccactta  tctccagct  ggggcaaag  2340
tgtcctttg  ctgtgatga  gggtttcgc  taaagggca  ttccgttag  cattgtgtc  2400
tggttggaa  gagaagcct  tggaataac  gtgttcctg  gtgtgaaca  atcttttgt  2460
caaatcctc  agctatcct  aatgggaga  acacaggaa  tccctctgg  gatattccc  2520
atggaaaag  aatatctta  acatgtgac  cccacccag  cagagggat  accttcaac  2580
tcattgggg  gagcaccat  cgctgcaca  gtgaccctc  tgggaatgg  gtttggagc  2640
gccctgccc  tcgctgtga  ctttctgtt  gtgctggtc  ctgtaaaac  ccagagcag  2700
ttccatttg  cagtcctac  atcccaatt  atgactttg  gtttccagt  gggacatct  2760
tgaattatg  atgccgtcc  gggtatttt  ggaaaatgt  ctctatctc  tgcctagaa  2820
acttggtct  gtcaagtgt  gaagacaac  gtagacgaa  atcatgtgg  cctccacca  2880
aacccttca  tggaatggt  catataaac  cagatacac  gtttggatc  acagttaat  2940
attcttgta  tgaagggtt  cgactcatt  gttccccat  tactacttg  ctcgtctca  3000
gcaataatg  cacatggga  aagaaggca  ctatttgtg  gatcatatc  tgtgagcca  3060
ctccaacca  atccaatgg  gacttctac  gcaacaata  aacatcttt  cacaatgga  3120
cggtggtaa  ttaccagtg  cacactgga  cagatggag  acagctgtt  gagcttgtg  3180
gagaacggt  aatatattg  accagcaaa  atgatcaag  tggtgtttg  agcagccct  3240
cccctcggt  tatttctac  aataaatgc  cagctccag  agttgaaaa  gcaattaga  3300
taccaggaa  caggagttt  ttttccctc  ctgagatca  cagatttag  tgtcagccc  3360
ggtttgtca  ggtagggtc  cacactgtg  agtgccaga  caatggcag  tgggggccc  3420
agctgccac  ctgctccag  gtgtgtcag  cgcctccag  aatcctgca  ggtgagcat  3480
ccctaagcc  tcaggacaa  ttttcacct  ggcaggaag  gttctacag  tgtgagccc  3540
gctatgacc  cagaggggc  gcgtctctg  actgcacgc  ccagggaga  tggagccct  3600
aagccccta  atgtacagt  aaatcctgt  atgacttcc  gggccaact  cctcatggc  3660
gtgtgctac  tccacttaa  ctccagctt  gggcaaagg  gtcctttgt  tgcgatgaa  3720
ggttccgat  aaaaggcag  tctgctagt  attgtgtct  ggctggaat  aaagccctt  3780
ggaatagca  tgttccagt  tgtgaacaa  tcttttgtc  aaatcctcc  gctatcctt  3840
atgggagac  cacaggaac  ccctttgga  atattccct  tggaaaaga  atatcttac  3900
catgcgaca  ccacccaga  agagggatg  ccttcaacc  cattgggga  agctccatc  3960
gctgcacaa  tgaccctca  gggaatggg  tttggagca  ccctgcccc  cgctgtgaa  4020
tttctgttc  tgctgcctg  ccacatcca  ccaagatcc  aaacgggca  tacattgga  4080
gacacgtat  tctatatct  cctgggatg  caatcagct  cacttgtga  cccggctac  4140
tgttagtgg  aaagggctt  attttctgt  cagaccagg  aatctggag  caattggat  4200
attattgca  agaagtaaa  tgtagcttc  cactgttta  gaatggaat  tcgaaggag  4260
tagaaatga  aaaagtata  cactatgga  attatgtga  tttgaagtg  gaagatggg  4320
atactctgg  aggcagtcc  tggagccag  gccaggcgg  tgacagatg  gaccctcct  4380
tggccaaat  tacctctcg  gcacatgat  ctctcatag  tggcacttt  tctggtacg  4440
tcttcttta  tttactcat  attttcctc  cttggataa  tctaaagca  agaaaaggc  4500
ataatgcac  tgaaaaccc  aaagaagtg  ctatccatt  acattctca  ggaggcagc  4560
gcgttcatc  ccgaactct  caaacaaat  aagaaaata  cagggtcct  ccttgacaa  4620
gtactatac  gctgaagaa  atctcgaat  caattttgg  gggaaagga  ccaattgat  4680
tcaacagaa  cagatctga  cttcataaa  tctttgaag  gacttcaca  agacgcaga  4740
atgtgcact  gaagatgct  ccccttccc  ggtacctag  aaagctcct  cctctttgt  4800
tgcgtcact  tgaaacccc  acccttctg  ctcgtgcta  acgcacaca  tatctagtc  4860
ggggaaaag  ctgcattta  gagatagaa  atagtttgg  ttacttaaa  gaataaggt  4920
ttgcctgga  tttctggtt  gtaaggtgg  cactgttct  ttttaaaat  tttgtaata  4980
ggaatgggc  cagtaagaa  agcttggaa  atgcagaaa  ttatgaaaa  taagtcact  5040
ataattatg  tacctactg  taaccactc  taatatttt  attcatttt  tgcctatct  5100
ctttcacat  tgtgttttt  tacatacgt  cttttcccc  cttagtttg  ttcctttta  5160
tttatagag  agaacccta  tcttttaaa  agtttagag  gaaatatat  ctatatcag  5220
ttttacttt  tctagggag  aaaattaat  tactagaaa  gcatgaaat  atcatggga  5280
gagtggtta  gactactga  gagaaatat  tggaaaata  gatttcgat  tcttctttt  5340
ttttgagat  gagtctggc  ctgtctccc  ggctggagt  cagtggcgt  atctcggct  5400
actgcaacg  ccgcctcccg  5420



<210> 2028
<211> 2039
<212> PRT
<213> Homo sapiens
<308> P17927
<400> 2028

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
  1               5                  10                  15
Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
             20                  25                  30
Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
         35                  40                  45
Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
     50                  55                  60
Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
 65                  70                  75                  80
Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                 85                  90                  95
Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
             100                105                110
Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
         115                120                125
Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
     130                135                140
Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
 145                150                155                160
Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                 165                170                175
Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
             180                185                190
Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
         195                200                205
Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
     210                215                220
Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
 225                230                235                240
Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                 245                250                255
Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
             260                265                270
Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
         275                280                285
Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
     290                295                300
His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
 305                310                315                320
Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                 325                330                335
Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
             340                345                350
Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
         355                360                365
Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
     370                375                380
Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
 385                390                395                400
Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                 405                410                415
Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
             420                425                430
Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val Asn Tyr 
         435                440                445
Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
     450                455                460
Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
 465                470                475                480
Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                 485                490                495
Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
             500                505                510
Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
         515                520                525
Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
     530                535                540
Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
 545                550                555                560
Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                 565                570                575
Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
             580                585                590
Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
         595                600                605
Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
     610                615                620
Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
 625                630                635                640
Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                 645                650                655
Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
             660                665                670
Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
         675                680                685
Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
     690                695                700
Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
 705                710                715                720
Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                 725                730                735
Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
             740                745                750
Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
         755                760                765
Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
     770                775                780
Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
 785                790                795                800
Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                 805                810                815
Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
             820                825                830
Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
         835                840                845
Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
     850                855                860
Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
 865                870                875                880
Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                 885                890                895
Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
             900                905                910
Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
         915                920                925
Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
     930                935                940
Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
 945                950                955                960
Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                 965                970                975
Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
             980                985                990
Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro 
         995                1000                1005
Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly 
     1010                1015                1020
Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His 
 1025                1030                1035                1040
Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr Ala His Trp Ser Thr 
                 1045                1050                1055
Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile 
             1060                1065                1070
Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly 
         1075                1080                1085
Ser Val Val Thr Tyr Arg Cys Asn Leu Gly Ser Arg Gly Arg Lys Val 
     1090                1095                1100
Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp 
 1105                1110                1115                1120
Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn 
                 1125                1130                1135
Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn 
             1140                1145                1150
Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro 
         1155                1160                1165
Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn 
     1170                1175                1180
Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro 
 1185                1190                1195                1200
Pro Glu Ile Leu His Gly Glu His Thr Pro Ser His Gln Asp Asn Phe 
                 1205                1210                1215
Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu 
             1220                1225                1230
Arg Gly Ala Ala Ser Leu His Cys Thr Pro Gln Gly Asp Trp Ser Pro 
         1235                1240                1245
Glu Ala Pro Arg Cys Ala Val Lys Ser Cys Asp Asp Phe Leu Gly Gln 
     1250                1255                1260
Leu Pro His Gly Arg Val Leu Phe Pro Leu Asn Leu Gln Leu Gly Ala 
 1265                1270                1275                1280
Lys Val Ser Phe Val Cys Asp Glu Gly Phe Arg Leu Lys Gly Ser Ser 
                 1285                1290                1295
Val Ser His Cys Val Leu Val Gly Met Arg Ser Leu Trp Asn Asn Ser 
             1300                1305                1310
Val Pro Val Cys Glu His Ile Phe Cys Pro Asn Pro Pro Ala Ile Leu 
         1315                1320                1325
Asn Gly Arg His Thr Gly Thr Pro Ser Gly Asp Ile Pro Tyr Gly Lys 
     1330                1335                1340
Glu Ile Ser Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Met Thr Phe 
 1345                1350                1355                1360
Asn Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro His Gly 
                 1365                1370                1375
Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Glu Leu Ser Val Arg 
             1380                1385                1390
Ala Gly His Cys Lys Thr Pro Glu Gln Phe Pro Phe Ala Ser Pro Thr 
         1395                1400                1405
Ile Pro Ile Asn Asp Phe Glu Phe Pro Val Gly Thr Ser Leu Asn Tyr 
     1410                1415                1420
Glu Cys Arg Pro Gly Tyr Phe Gly Lys Met Phe Ser Ile Ser Cys Leu 
 1425                1430                1435                1440
Glu Asn Leu Val Trp Ser Ser Val Glu Asp Asn Cys Arg Arg Lys Ser 
                 1445                1450                1455
Cys Gly Pro Pro Pro Glu Pro Phe Asn Gly Met Val His Ile Asn Thr 
             1460                1465                1470
Asp Thr Gln Phe Gly Ser Thr Val Asn Tyr Ser Cys Asn Glu Gly Phe 
         1475                1480                1485
Arg Leu Ile Gly Ser Pro Ser Thr Thr Cys Leu Val Ser Gly Asn Asn 
     1490                1495                1500
Val Thr Trp Asp Lys Lys Ala Pro Ile Cys Glu Ile Ile Ser Cys Glu 
 1505                1510                1515                1520
Pro Pro Pro Thr Ile Ser Asn Gly Asp Phe Tyr Ser Asn Asn Arg Thr 
                 1525                1530                1535
Ser Phe His Asn Gly Thr Val Val Thr Tyr Gln Cys His Thr Gly Pro 
             1540                1545                1550
Asp Gly Glu Gln Leu Phe Glu Leu Val Gly Glu Arg Ser Ile Tyr Cys 
         1555                1560                1565
Thr Ser Lys Asp Asp Gln Val Gly Val Trp Ser Ser Pro Pro Pro Arg 
     1570                1575                1580
Cys Ile Ser Thr Asn Lys Cys Thr Ala Pro Glu Val Glu Asn Ala Ile 
 1585                1590                1595                1600
Arg Val Pro Gly Asn Arg Ser Phe Phe Ser Leu Thr Glu Ile Ile Arg 
                 1605                1610                1615
Phe Arg Cys Gln Pro Gly Phe Val Met Val Gly Ser His Thr Val Gln 
             1620                1625                1630
Cys Gln Thr Asn Gly Arg Trp Gly Pro Lys Leu Pro His Cys Ser Arg 
         1635                1640                1645
Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His Thr Leu Ser 
     1650                1655                1660
His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
 1665                1670                1675                1680
Pro Ser Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys Thr Pro Gln 
                 1685                1690                1695
Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Thr Val Lys Ser Cys Asp 
             1700                1705                1710
Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Leu Pro Leu Asn 
         1715                1720                1725
Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly Phe Arg 
     1730                1735                1740
Leu Lys Gly Arg Ser Ala Ser His Cys Val Leu Ala Gly Met Lys Ala 
 1745                1750                1755                1760
Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Asn 
                 1765                1770                1775
Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Phe Gly Asp 
             1780                1785                1790
Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Ala Cys Asp Thr His Pro Asp 
         1795                1800                1805
Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Ser Ile Arg Cys Thr 
     1810                1815                1820
Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
 1825                1830                1835                1840
Glu Leu Ser Val Pro Ala Ala Cys Pro His Pro Pro Lys Ile Gln Asn 
                 1845                1850                1855
Gly His Tyr Ile Gly Gly His Val Ser Leu Tyr Leu Pro Gly Met Thr 
             1860                1865                1870
Ile Ser Tyr Thr Cys Asp Pro Gly Tyr Leu Leu Val Gly Lys Gly Phe 
         1875                1880                1885
Ile Phe Cys Thr Asp Gln Gly Ile Trp Ser Gln Leu Asp His Tyr Cys 
     1890                1895                1900
Lys Glu Val Asn Cys Ser Phe Pro Leu Phe Met Asn Gly Ile Ser Lys 
 1905                1910                1915                1920
Glu Leu Glu Met Lys Lys Val Tyr His Tyr Gly Asp Tyr Val Thr Leu 
                 1925                1930                1935
Lys Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Pro Trp Ser Gln Cys 
             1940                1945                1950
Gln Ala Asp Asp Arg Trp Asp Pro Pro Leu Ala Lys Cys Thr Ser Arg 
         1955                1960                1965
Ala His Asp Ala Leu Ile Val Gly Thr Leu Ser Gly Thr Ile Phe Phe 
     1970                1975                1980
Ile Leu Leu Ile Ile Phe Leu Ser Trp Ile Ile Leu Lys His Arg Lys 
 1985                1990                1995                2000
Gly Asn Asn Ala His Glu Asn Pro Lys Glu Val Ala Ile His Leu His 
                 2005                2010                2015
Ser Gln Gly Gly Ser Ser Val His Pro Arg Thr Leu Gln Thr Asn Glu 
             2020                2025                2030
Glu Asn Ser Arg Val Leu Pro 
         2035



<210> 2029
<211> 1272
<212> DNA
<213> Rattus norvegicus
<308> D42116
<400> 2029

cctcattgg  tcctcctct  ctatgtgca  aatctctga  cagagcgtt  cctgggatg  60
cgaggcacc  atttgtgaa  caattcctt  tgagatacc  ccaagcatt  ccaatggag  120
tttcttcag  cctaacaga  aagattttc  ttatggaat  gtagttacc  accagtgca  180
cactgatgc  agagggaag  agctcttta  cctggtggg  gagccctcc  tacactgta  240
cagcatcga  ggtcaagtt  gagtctgga  tggccctcc  cctcagtgc  ttgaactca  300
caaatgtac  cctccccat  ttgaaaatg  agtcatagt  tctaaaaac  aaagcttgt  360
ttccttaag  gatatggtg  agtttagat  tcaggatgg  tttatgatg  aaggagaca  420
cagtgtgta  tgtcgatcc  taaacagat  ggagcctca  ttaccaagc  gcttcaagg  480
gaaatcctg  ggtgctttc  tgggtgagc  tcctaatgg  catgtattc  ttccacaaa  540
tcttcaact  ggggccaaa  tgacctttg  ttgtaatac  gggtatcaa  taaaaggca  600
ttcttctag  cattgtgtt  ttgatggag  ggaaagcat  tggaatagc  gcgttcctg  660
gtgtgaaca  gtgatatgt  aactccctc  ggatatgag  ggattccag  aagggttgc  720
aatgaaaaa  gattattac  atggagata  tgtagcctt  gaatgtgag  atgggtata  780
tctagaagg  agttctcag  gccagtgcc  gtccgatgc  agctgggat  ctcctctgc  840
caaatgtgt  tctcaagtg  tatgtaaac  ccctcagga  atgagtgga  tccagaaag  900
gttgcaaat  aaaaaagat  attactatg  agataatgt  gccttggaa  gtgaggatg  960
gtatactct  gaaggcagt  ctcagagcc  gtgccagtc  gatgccagc  gggatcctc  1020
tctgcccaa  tgtgtctct  aagtgatat  taaactccc  caggatatg  gtggattcc  1080
gaaagggtt  caaatgaaa  aagattatt  ctatggaga  aatgtagcc  tggaatgtg  1140
ggatgggta  actctagaa  gcagttctc  gagccagtg  cagtccgat  ccagctggg  1200
tcctcctct  cccaaatgt  tctctcgct  aaacagtgg  ctaatagct  gaattttca  1260
tgggataat  gt  1272



<210> 2030
<211> 559
<212> PRT
<213> Rattus norvegicus
<308> BAA22548
<400> 2030

Met Glu Ala Ser Ser Pro Leu Asp Pro Val Gly Arg Leu Val Ala Phe 
  1               5                  10                  15
Cys Arg Gly Gly Val His Leu Ala Val Leu Leu Leu Phe Leu Ser Pro 
             20                  25                  30
Ser Thr Leu Gly Gln Cys Pro Ala Pro Pro Leu Phe Pro Tyr Ala Lys 
         35                  40                  45
Pro Ile Asn Pro Thr Asp Glu Ser Thr Phe Pro Val Gly Thr Ser Leu 
     50                  55                  60
Lys Tyr Glu Cys Arg Pro Gly Tyr Ile Lys Arg Gln Phe Ser Ile Thr 
 65                  70                  75                  80
Cys Glu Val Asn Ser Val Trp Thr Ser Pro Gln Asp Val Cys Ile Arg 
                 85                  90                  95
Lys Gln Cys Glu Thr Pro Leu Asp Pro Gln Asn Gly Ile Val His Val 
             100                105                110
Asn Thr Asp Ile Arg Phe Gly Ser Ser Ile Thr Tyr Thr Cys Asn Glu 
         115                120                125
Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Met Cys Ile Ile Ser Asp 
     130                135                140
Gln Ser Val Ala Trp Asp Ala Glu Ala Pro Ile Cys Glu Ser Ile Pro 
 145                150                155                160
Cys Glu Ile Pro Pro Ser Ile Pro Asn Gly Asp Phe Phe Ser Pro Asn 
                 165                170                175
Arg Glu Asp Phe His Tyr Gly Met Val Val Thr Tyr Gln Cys Asn Thr 
             180                185                190
Asp Ala Arg Gly Lys Lys Leu Phe Asn Leu Val Gly Glu Pro Ser Ile 
         195                200                205
His Cys Thr Ser Ile Asp Gly Gln Val Gly Val Trp Ser Gly Pro Pro 
     210                215                220
Pro Gln Cys Ile Glu Leu Asn Lys Cys Thr Pro Pro His Val Glu Asn 
 225                230                235                240
Ala Val Ile Val Ser Lys Asn Lys Ser Leu Phe Ser Leu Arg Asp Met 
                 245                250                255
Val Glu Phe Arg Cys Gln Asp Gly Phe Met Met Lys Gly Asp Ser Ser 
             260                265                270
Val Tyr Cys Arg Ser Leu Asn Arg Trp Glu Pro Gln Leu Pro Ser Cys 
         275                280                285
Phe Lys Val Lys Ser Cys Gly Ala Phe Leu Gly Glu Leu Pro Asn Gly 
     290                295                300
His Val Phe Val Pro Gln Asn Leu Gln Leu Gly Ala Lys Val Thr Phe 
 305                310                315                320
Val Cys Asn Thr Gly Tyr Gln Leu Lys Gly Asn Ser Ser Ser His Cys 
                 325                330                335
Val Leu Asp Gly Val Glu Ser Ile Trp Asn Ser Ser Val Pro Val Cys 
             340                345                350
Glu Gln Val Ile Cys Lys Leu Pro Gln Asp Met Ser Gly Phe Gln Lys 
         355                360                365
Gly Leu Gln Met Lys Lys Asp Tyr Tyr Tyr Gly Asp Asn Val Ala Leu 
     370                375                380
Glu Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Ser Gln Ser Gln Cys 
 385                390                395                400
Gln Ser Asp Ala Ser Trp Asp Pro Pro Leu Pro Lys Cys Val Ser Gln 
                 405                410                415
Val Ile Cys Lys Leu Pro Gln Asp Met Ser Gly Phe Gln Lys Gly Leu 
             420                425                430
Gln Met Lys Lys Asp Tyr Tyr Tyr Gly Asp Asn Val Ala Leu Glu Cys 
         435                440                445
Glu Asp Gly Tyr Thr Leu Glu Gly Ser Ser Gln Ser Gln Cys Gln Ser 
     450                455                460
Asp Ala Ser Trp Asp Pro Pro Leu Pro Lys Cys Val Ser Arg Ser Asn 
 465                470                475                480
Ser Gly Leu Ile Ala Gly Ile Phe Ile Gly Ile Ile Val Leu Ile Leu 
                 485                490                495
Phe Ile Ile Phe Ser Tyr Trp Met Ile Met Lys Phe Lys Lys Arg Asn 
             500                505                510
Ser Thr Asn Glu Lys Cys Lys Glu Val Gly Ile Tyr Leu Asn Ser Lys 
         515                520                525
Glu Asp Ser Cys Val Gln Pro Gln Ser Leu Leu Thr Ser Gln Glu Asn 
     530                535                540
Asn Ser Thr Ser Ser Pro Ala Arg Asn Ser Leu Thr Gln Glu Val 
 545                550                555



<210> 2031
<211> 5420
<212> DNA
<213> Homo sapiens
<308> X05309
<400> 2031

ccaagttga  aacccaaac  aatgcatct  actttccca  tgggacatc  ttaaagtac  60
aatgccgtc  tgagtacta  gggaggcca  tctctatca  atgtctaga  aacctggtc  120
ggtcaagtc  caaagatgt  tgtaaacgt  aatcatgta  aactcctcc  gatccagtg  180
atggcatgg  gcatgtgat  acagacatc  aggttggat  cagaatcaa  tattcttgt  240
ctacagggc  ccgactcat  ggtcactca  ctgctgaat  tatcctctc  ggcaatgct  300
cccattgga  cacgaagcc  ccaatttgt  aacgaattc  ttgtgggct  ccccccacc  360
tcgccaatg  agatttcat  agcaccaac  gagagaatt  tcactatgg  tcagtggtg  420
cctaccgct  caatcctgg  agcggaggg  gaaaggtgt  tgagcttgt  ggtgagccc  480
ccatatact  caccagcaa  gacgatcaa  tgggcatct  gagcggccc  gcccctcag  540
gcattatac  taacaaatg  acgcctcca  atgtggaaa  tggaatatt  gtatctgac  600
acagaagct  attttcctt  aatgaagtt  tggagttta  gtgtcagcc  ggctttgtc  660
tgaaaggac  ccgccgtgt  aagtgccag  ccctgaaca  atgggagcc  gagctacca  720
gctgctcca  ggtatgtca  ccacctcca  atgtcctgc  tgctgagcg  acccaaagg  780
acaaggaca  cttttcacc  gggcaggaa  tgttctaca  ctgtgagcc  ggctatgac  840
tcagagggg  tgcgtctat  cgctgcaca  cccagggag  ctggagccc  gcagccccc  900
catgtgaag  gaaatcctg  gatgacttc  tgggccaac  tcttaatgg  cgtgtgcta  960
ttccagtaa  tctccagct  ggagcaaaa  tggattttg  ttgtgatga  ggatttcaa  1020
taaaaggca  ctctgctag  tattgtgtc  tggctggaa  ggaaagcct  tggaatagc  1080
gtgttccag  gtgtgaaca  atcttttgt  caagtcctc  agttattcc  aatgggaga  1140
acacaggaa  acctctgga  gtctttccc  ttggaaaag  agtaaatta  acatgcgac  1200
cccacccag  cagagggac  agcttcgac  tcattggag  gagcaccat  cgctgcaca  1260
gtgaccctc  agggaatgg  gtttggagc  gccctgccc  tcgctgtgg  attctgggt  1320
actgtcaag  cccagatca  tttctgttt  ccaagttga  aacccaaac  aatgcatct  1380
actttccca  tgggacatc  ttaaagtac  aatgccgtc  tgagtacta  gggaggcca  1440
tctctatca  atgtctaga  aacctggtc  ggtcaagtc  caaagatgt  tgtaaacgt  1500
aatcatgta  aactcctcc  gatccagtg  atggcatgg  gcatgtgat  acagacatc  1560
aggttggat  cagaatcaa  tattcttgt  ctacagggc  ccgactcat  ggtcactca  1620
ctgctgaat  tatcctctc  ggcaatact  cccattgga  cacgaagcc  ccaatttgt  1680
aacgaattc  ttgtgggct  cccccaacc  tcgccaatg  agatttcat  agcaccaac  1740
gagagaatt  tcactatgg  tcagtggtg  cctaccgct  caatcttgg  agcagaggg  1800
gaaaggtgt  tgagcttgt  ggtgagccc  ccatatact  caccagcaa  gacgatcaa  1860
tgggcatct  gagcggccc  gcccctcag  gcattatac  taacaaatg  acgcctcca  1920
atgtggaaa  tggaatatt  gtatctgac  acagaagct  attttcctt  aatgaagtt  1980
tggagttta  gtgtcagcc  ggctttgtc  tgaaaggac  ccgccgtgt  aagtgccag  2040
ccctgaaca  atgggagcc  gagttacca  gctgctcca  ggtgtgtca  ccgcctcca  2100
aaatcctgc  tggtgagca  accccaagc  atcaggaca  cttttcacc  gggcaggaa  2160
tgttctaca  ctgtgagcc  ggctatgac  tcagagggg  tgcgtctct  cactgcaca  2220
cccagggag  ctggagccc  gaagccccg  gatgtgcag  gaaatcctg  gatgacttc  2280
tgggtcaac  ccctcatgg  cgtgtgcta  ttccactta  tctccagct  ggggcaaag  2340
tgtcctttg  ctgtgatga  gggtttcgc  taaagggca  ttccgttag  cattgtgtc  2400
tggttggaa  gagaagcct  tggaataac  gtgttcctg  gtgtgaaca  atcttttgt  2460
caaatcctc  agctatcct  aatgggaga  acacaggaa  tccctctgg  gatattccc  2520
atggaaaag  aatatctta  acatgtgac  cccacccag  cagagggat  accttcaac  2580
tcattgggg  gagcaccat  cgctgcaca  gtgaccctc  tgggaatgg  gtttggagc  2640
gccctgccc  tcgctgtga  ctttctgtt  gtgctggtc  ctgtaaaac  ccagagcag  2700
ttccatttg  cagtcctac  atcccaatt  atgactttg  gtttccagt  gggacatct  2760
tgaattatg  atgccgtcc  gggtatttt  ggaaaatgt  ctctatctc  tgcctagaa  2820
acttggtct  gtcaagtgt  gaagacaac  gtagacgaa  atcatgtgg  cctccacca  2880
aacccttca  tggaatggt  catataaac  cagatacac  gtttggatc  acagttaat  2940
attcttgta  tgaagggtt  cgactcatt  gttccccat  tactacttg  ctcgtctca  3000
gcaataatg  cacatggga  aagaaggca  ctatttgtg  gatcatatc  tgtgagcca  3060
ctccaacca  atccaatgg  gacttctac  gcaacaata  aacatcttt  cacaatgga  3120
cggtggtaa  ttaccagtg  cacactgga  cagatggag  acagctgtt  gagcttgtg  3180
gagaacggt  aatatattg  accagcaaa  atgatcaag  tggtgtttg  agcagccct  3240
cccctcggt  tatttctac  aataaatgc  cagctccag  agttgaaaa  gcaattaga  3300
taccaggaa  caggagttt  ttttccctc  ctgagatca  cagatttag  tgtcagccc  3360
ggtttgtca  ggtagggtc  cacactgtg  agtgccaga  caatggcag  tgggggccc  3420
agctgccac  ctgctccag  gtgtgtcag  cgcctccag  aatcctgca  ggtgagcat  3480
ccctaagcc  tcaggacaa  ttttcacct  ggcaggaag  gttctacag  tgtgagccc  3540
gctatgacc  cagaggggc  gcgtctctg  actgcacgc  ccagggaga  tggagccct  3600
aagccccta  atgtacagt  aaatcctgt  atgacttcc  gggccaact  cctcatggc  3660
gtgtgctac  tccacttaa  ctccagctt  gggcaaagg  gtcctttgt  tgcgatgaa  3720
ggttccgat  aaaaggcag  tctgctagt  attgtgtct  ggctggaat  aaagccctt  3780
ggaatagca  tgttccagt  tgtgaacaa  tcttttgtc  aaatcctcc  gctatcctt  3840
atgggagac  cacaggaac  ccctttgga  atattccct  tggaaaaga  atatcttac  3900
catgcgaca  ccacccaga  agagggatg  ccttcaacc  cattgggga  agctccatc  3960
gctgcacaa  tgaccctca  gggaatggg  tttggagca  ccctgcccc  cgctgtgaa  4020
tttctgttc  tgctgcctg  ccacatcca  ccaagatcc  aaacgggca  tacattgga  4080
gacacgtat  tctatatct  cctgggatg  caatcagct  cacttgtga  cccggctac  4140
tgttagtgg  aaagggctt  attttctgt  cagaccagg  aatctggag  caattggat  4200
attattgca  agaagtaaa  tgtagcttc  cactgttta  gaatggaat  tcgaaggag  4260
tagaaatga  aaaagtata  cactatgga  attatgtga  tttgaagtg  gaagatggg  4320
atactctgg  aggcagtcc  tggagccag  gccaggcgg  tgacagatg  gaccctcct  4380
tggccaaat  tacctctcg  gcacatgat  ctctcatag  tggcacttt  tctggtacg  4440
tcttcttta  tttactcat  attttcctc  cttggataa  tctaaagca  agaaaaggc  4500
ataatgcac  tgaaaaccc  aaagaagtg  ctatccatt  acattctca  ggaggcagc  4560
gcgttcatc  ccgaactct  caaacaaat  aagaaaata  cagggtcct  ccttgacaa  4620
gtactatac  gctgaagaa  atctcgaat  caattttgg  gggaaagga  ccaattgat  4680
tcaacagaa  cagatctga  cttcataaa  tctttgaag  gacttcaca  agacgcaga  4740
atgtgcact  gaagatgct  ccccttccc  ggtacctag  aaagctcct  cctctttgt  4800
tgcgtcact  tgaaacccc  acccttctg  ctcgtgcta  acgcacaca  tatctagtc  4860
ggggaaaag  ctgcattta  gagatagaa  atagtttgg  ttacttaaa  gaataaggt  4920
ttgcctgga  tttctggtt  gtaaggtgg  cactgttct  ttttaaaat  tttgtaata  4980
ggaatgggc  cagtaagaa  agcttggaa  atgcagaaa  ttatgaaaa  taagtcact  5040
ataattatg  tacctactg  taaccactc  taatatttt  attcatttt  tgcctatct  5100
ctttcacat  tgtgttttt  tacatacgt  cttttcccc  cttagtttg  ttcctttta  5160
tttatagag  agaacccta  tcttttaaa  agtttagag  gaaatatat  ctatatcag  5220
ttttacttt  tctagggag  aaaattaat  tactagaaa  gcatgaaat  atcatggga  5280
gagtggtta  gactactga  gagaaatat  tggaaaata  gatttcgat  tcttctttt  5340
ttttgagat  gagtctggc  ctgtctccc  ggctggagt  cagtggcgt  atctcggct  5400
actgcaacg  ccgcctcccg  5420



<210> 2032
<211> 2039
<212> PRT
<213> Homo sapiens
<308> P17927
<400> 2032

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
  1               5                  10                  15
Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
             20                  25                  30
Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
         35                  40                  45
Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
     50                  55                  60
Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
 65                  70                  75                  80
Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                 85                  90                  95
Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
             100                105                110
Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
         115                120                125
Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
     130                135                140
Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
 145                150                155                160
Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                 165                170                175
Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
             180                185                190
Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
         195                200                205
Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
     210                215                220
Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
 225                230                235                240
Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                 245                250                255
Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
             260                265                270
Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
         275                280                285
Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
     290                295                300
His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
 305                310                315                320
Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                 325                330                335
Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
             340                345                350
Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
         355                360                365
Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
     370                375                380
Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
 385                390                395                400
Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                 405                410                415
Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
             420                425                430
Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val Asn Tyr 
         435                440                445
Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
     450                455                460
Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
 465                470                475                480
Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                 485                490                495
Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
             500                505                510
Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
         515                520                525
Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
     530                535                540
Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
 545                550                555                560
Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                 565                570                575
Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
             580                585                590
Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
         595                600                605
Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
     610                615                620
Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
 625                630                635                640
Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                 645                650                655
Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
             660                665                670
Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
         675                680                685
Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
     690                695                700
Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
 705                710                715                720
Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                 725                730                735
Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
             740                745                750
Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
         755                760                765
Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
     770                775                780
Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
 785                790                795                800
Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                 805                810                815
Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
             820                825                830
Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
         835                840                845
Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
     850                855                860
Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
 865                870                875                880
Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                 885                890                895
Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
             900                905                910
Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
         915                920                925
Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
     930                935                940
Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
 945                950                955                960
Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                 965                970                975
Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
             980                985                990
Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro 
         995                1000                1005
Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly 
     1010                1015                1020
Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His 
 1025                1030                1035                1040
Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr Ala His Trp Ser Thr 
                 1045                1050                1055
Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile 
             1060                1065                1070
Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly 
         1075                1080                1085
Ser Val Val Thr Tyr Arg Cys Asn Leu Gly Ser Arg Gly Arg Lys Val 
     1090                1095                1100
Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp 
 1105                1110                1115                1120
Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn 
                 1125                1130                1135
Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn 
             1140                1145                1150
Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro 
         1155                1160                1165
Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn 
     1170                1175                1180
Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro 
 1185                1190                1195                1200
Pro Glu Ile Leu His Gly Glu His Thr Pro Ser His Gln Asp Asn Phe 
                 1205                1210                1215
Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu 
             1220                1225                1230
Arg Gly Ala Ala Ser Leu His Cys Thr Pro Gln Gly Asp Trp Ser Pro 
         1235                1240                1245
Glu Ala Pro Arg Cys Ala Val Lys Ser Cys Asp Asp Phe Leu Gly Gln 
     1250                1255                1260
Leu Pro His Gly Arg Val Leu Phe Pro Leu Asn Leu Gln Leu Gly Ala 
 1265                1270                1275                1280
Lys Val Ser Phe Val Cys Asp Glu Gly Phe Arg Leu Lys Gly Ser Ser 
                 1285                1290                1295
Val Ser His Cys Val Leu Val Gly Met Arg Ser Leu Trp Asn Asn Ser 
             1300                1305                1310
Val Pro Val Cys Glu His Ile Phe Cys Pro Asn Pro Pro Ala Ile Leu 
         1315                1320                1325
Asn Gly Arg His Thr Gly Thr Pro Ser Gly Asp Ile Pro Tyr Gly Lys 
     1330                1335                1340
Glu Ile Ser Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Met Thr Phe 
 1345                1350                1355                1360
Asn Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro His Gly 
                 1365                1370                1375
Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Glu Leu Ser Val Arg 
             1380                1385                1390
Ala Gly His Cys Lys Thr Pro Glu Gln Phe Pro Phe Ala Ser Pro Thr 
         1395                1400                1405
Ile Pro Ile Asn Asp Phe Glu Phe Pro Val Gly Thr Ser Leu Asn Tyr 
     1410                1415                1420
Glu Cys Arg Pro Gly Tyr Phe Gly Lys Met Phe Ser Ile Ser Cys Leu 
 1425                1430                1435                1440
Glu Asn Leu Val Trp Ser Ser Val Glu Asp Asn Cys Arg Arg Lys Ser 
                 1445                1450                1455
Cys Gly Pro Pro Pro Glu Pro Phe Asn Gly Met Val His Ile Asn Thr 
             1460                1465                1470
Asp Thr Gln Phe Gly Ser Thr Val Asn Tyr Ser Cys Asn Glu Gly Phe 
         1475                1480                1485
Arg Leu Ile Gly Ser Pro Ser Thr Thr Cys Leu Val Ser Gly Asn Asn 
     1490                1495                1500
Val Thr Trp Asp Lys Lys Ala Pro Ile Cys Glu Ile Ile Ser Cys Glu 
 1505                1510                1515                1520
Pro Pro Pro Thr Ile Ser Asn Gly Asp Phe Tyr Ser Asn Asn Arg Thr 
                 1525                1530                1535
Ser Phe His Asn Gly Thr Val Val Thr Tyr Gln Cys His Thr Gly Pro 
             1540                1545                1550
Asp Gly Glu Gln Leu Phe Glu Leu Val Gly Glu Arg Ser Ile Tyr Cys 
         1555                1560                1565
Thr Ser Lys Asp Asp Gln Val Gly Val Trp Ser Ser Pro Pro Pro Arg 
     1570                1575                1580
Cys Ile Ser Thr Asn Lys Cys Thr Ala Pro Glu Val Glu Asn Ala Ile 
 1585                1590                1595                1600
Arg Val Pro Gly Asn Arg Ser Phe Phe Ser Leu Thr Glu Ile Ile Arg 
                 1605                1610                1615
Phe Arg Cys Gln Pro Gly Phe Val Met Val Gly Ser His Thr Val Gln 
             1620                1625                1630
Cys Gln Thr Asn Gly Arg Trp Gly Pro Lys Leu Pro His Cys Ser Arg 
         1635                1640                1645
Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His Thr Leu Ser 
     1650                1655                1660
His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
 1665                1670                1675                1680
Pro Ser Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys Thr Pro Gln 
                 1685                1690                1695
Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Thr Val Lys Ser Cys Asp 
             1700                1705                1710
Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Leu Pro Leu Asn 
         1715                1720                1725
Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly Phe Arg 
     1730                1735                1740
Leu Lys Gly Arg Ser Ala Ser His Cys Val Leu Ala Gly Met Lys Ala 
 1745                1750                1755                1760
Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Asn 
                 1765                1770                1775
Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Phe Gly Asp 
             1780                1785                1790
Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Ala Cys Asp Thr His Pro Asp 
         1795                1800                1805
Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Ser Ile Arg Cys Thr 
     1810                1815                1820
Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
 1825                1830                1835                1840
Glu Leu Ser Val Pro Ala Ala Cys Pro His Pro Pro Lys Ile Gln Asn 
                 1845                1850                1855
Gly His Tyr Ile Gly Gly His Val Ser Leu Tyr Leu Pro Gly Met Thr 
             1860                1865                1870
Ile Ser Tyr Thr Cys Asp Pro Gly Tyr Leu Leu Val Gly Lys Gly Phe 
         1875                1880                1885
Ile Phe Cys Thr Asp Gln Gly Ile Trp Ser Gln Leu Asp His Tyr Cys 
     1890                1895                1900
Lys Glu Val Asn Cys Ser Phe Pro Leu Phe Met Asn Gly Ile Ser Lys 
 1905                1910                1915                1920
Glu Leu Glu Met Lys Lys Val Tyr His Tyr Gly Asp Tyr Val Thr Leu 
                 1925                1930                1935
Lys Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Pro Trp Ser Gln Cys 
             1940                1945                1950
Gln Ala Asp Asp Arg Trp Asp Pro Pro Leu Ala Lys Cys Thr Ser Arg 
         1955                1960                1965
Ala His Asp Ala Leu Ile Val Gly Thr Leu Ser Gly Thr Ile Phe Phe 
     1970                1975                1980
Ile Leu Leu Ile Ile Phe Leu Ser Trp Ile Ile Leu Lys His Arg Lys 
 1985                1990                1995                2000
Gly Asn Asn Ala His Glu Asn Pro Lys Glu Val Ala Ile His Leu His 
                 2005                2010                2015
Ser Gln Gly Gly Ser Ser Val His Pro Arg Thr Leu Gln Thr Asn Glu 
             2020                2025                2030
Glu Asn Ser Arg Val Leu Pro 
         2035



<210> 2033
<211> 560
<212> DNA
<213> Rattus norvegicus
<308> D42137
<400> 2033

gctgtggct  ttgtgagtc  tggagttga  agagcatgt  tgggttcca  ggcgacaca  60
ctggagact  taagaaggc  ctgctgctc  tctgtggag  cgaggatga  tgaggagct  120
cctggagtg  cctgggccc  cctgctgcc  accatcagc  tccttcagc  ccacgccta  180
ttacgttca  tgcctgcct  cctgccacg  tgccttact  acacgagtg  gtgctaatg  240
ccaaagctg  ctcgaatga  agcagtgtt  tgctgttct  tctgacaga  cttcccacg  300
ctctcagtc  agtatctct  agttgcgtt  tctatcctc  tctaaagct  catttatat  360
aagttaata  ccatattac  ttgaacgga  ccttagcca  gaaattgtg  actcttgga  420
gtgctgtca  tcaagctta  tgctctagc  gacctgaaa  attaagatg  tcgtaatat  480
agaaacgtt  ccgacaaat  aacattctc  tccctccaa  tcctgtgta  gctcgtgtt  540
agaacgctt  tttaacaatg  560



<210> 2034
<211> 318
<212> PRT
<213> Rattus norvegicus
<308> BAA07708
<400> 2034

Ala Leu Arg Gly Thr Val Thr Asp Phe Ser Gly Phe Asp Gly Arg Ala 
  1               5                  10                  15
Asp Ala Glu Val Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu 
             20                  25                  30
Asp Ser Ile Leu Asn Leu Leu Thr Ala Arg Ser Asn Ala Gln Arg Gln 
         35                  40                  45
Gln Ile Ala Glu Glu Phe Lys Thr Leu Phe Gly Arg Asp Leu Val Asn 
     50                  55                  60
Asp Met Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile Val Ala 
 65                  70                  75                  80
Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys His Ala 
                 85                  90                  95
Leu Lys Gly Ala Gly Thr Asp Glu Lys Val Leu Thr Glu Ile Ile Ala 
             100                105                110
Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Ala Tyr Glu Glu 
         115                120                125
Glu Tyr Gly Ser Asn Leu Glu Asp Asp Val Val Gly Asp Thr Ser Gly 
     130                135                140
Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn Arg Asp Pro 
 145                150                155                160
Asp Thr Ala Ile Asp Asp Ala Gln Val Glu Leu Asp Ala Gln Ala Leu 
                 165                170                175
Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu Lys Phe Ile 
             180                185                190
Thr Ile Leu Gly Thr Arg Ser Val Ser His Leu Arg Arg Val Phe Asp 
         195                200                205
Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr Ile Asp Arg 
     210                215                220
Glu Thr Ser Gly Asn Leu Glu Asn Leu Leu Leu Ala Val Val Lys Ser 
 225                230                235                240
Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr Tyr Ala Met 
                 245                250                255
Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val Ile Val Ser 
             260                265                270
Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg Lys Asn 
         275                280                285
Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr Ser Gly Asp 
     290                295                300
Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Gly Glu Asp Asp 
 305                310                315



<210> 2035
<211> 1630
<212> DNA
<213> Homo sapiens
<308> NM_001154
<400> 2035

agggccggg  tggggcgct  gcgtttccg  tgcttggat  agtctaggt  cagctgcgg  60
tccttcagc  tctgcatct  ggcgtcgcc  cgcgtaccg  cgcccggct  tccgccgct  120
tcccggggg  tcggggcac  tgggtccca  agtctggtc  tgcttcacc  tcccctgac  180
tgagtagtc  ccatggcac  ggttctcag  ggcactgtg  ctgacttcc  tggatttga  240
gagcgggct  atgcagaaa  tcttcggaa  gctatgaaa  gcttgggca  agatgagga  300
agcatcctg  ctctgttga  atcccgaag  aatgctcag  gccaggaaa  ctctgcagc  360
tttaagact  tgtttggca  ggatcttct  gatgacctg  aatcagaac  aactggaaa  420
tttgaaaaa  taattgtgg  tctgatgaa  ccctctcgg  tttatgatg  ttatgaact  480
aaacatgcc  tgaagggag  tggaacaaa  gaaaaagta  tgacagaaa  tattgcttc  540
aggacacct  aagaactga  agccatcaa  caagtttat  aagaagaat  tggctcaag  600
ctggaagat  acgtggtgg  ggacacttc  gggtactac  agcggatgt  ggtggttct  660
cttcaggct  acagagacc  tgatgctgg  attgatgaa  ctcaagttg  acaagatgc  720
caggcttta  ttcaggctg  agaacttaa  tgggggaca  atgaagaaa  gtttatcac  780
atctttgga  cacgaagtg  gtctcattt  agaaaggtg  ttgacaagt  catgactat  840
tcaggattt  aaattgagg  aaccattga  cgcgagact  ctggcaatt  agagcaact  900
ctccttgct  ttgtgaaat  tattcgaag  atacctgcc  accttgcag  gaccctcta  960
tatgctatg  agggagctg  gacagatga  cataccctc  tcagagtca  ggtttccag  1020
agtgagatt  atctgttta  catcaggaa  gagtttagg  agaattttg  cacctctct  1080
tattccatg  ttaagggag  tacatctgg  gactataag  aagctcttc  gctgctctg  1140
ggagaagat  actaacgtg  cacggggaa  agctccctg  tgtgtgcct  caccacccc  1200
ctgccttcc  tcagcacct  tagctgcat  tgtatgcca  tgcttaaca  attgcctta  1260
tcatactag  atgctcatg  ccaacacat  cacgtcata  aagaaaata  tggtgcttc  1320
ttctgatct  tagtggaga  ctctttgac  gctgtagta  taaagtgta  ttaatgtta  1380
taagtttaa  gcctggcca  tttccattt  tatatattt  ttaagaggc  agagtgctt  1440
tagcctttt  taaaaactc  atttatatt  catttgtaa  catgatact  taattagaa  1500
cttagcctt  aaattgtga  ctcttggaa  tgttattag  gaagttcgc  actaaacta  1560
acctgtaaa  ttatgatga  tgtattcaa  agattaatg  aaaataaac  tttctgtcc  1620
cctgaattat  1630



<210> 2036
<211> 319
<212> PRT
<213> Homo sapiens
<308> P08758
<400> 2036

Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp Glu 
  1               5                  10                  15
Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly Thr 
             20                  25                  30
Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala Gln 
         35                  40                  45
Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp Leu 
     50                  55                  60
Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile 
 65                  70                  75                  80
Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys 
                 85                  90                  95
His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu Ile 
             100                105                110
Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val Tyr 
         115                120                125
Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp Thr 
     130                135                140
Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn Arg 
 145                150                155                160
Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala Gln 
                 165                170                175
Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu Lys 
             180                185                190
Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys Val 
         195                200                205
Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr Ile 
     210                215                220
Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val Val 
 225                230                235                240
Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr Tyr 
                 245                250                255
Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val Met 
             260                265                270
Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg 
         275                280                285
Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr Ser 
     290                295                300
Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
 305                310                315



<210> 2038
<211> 304
<212> PRT
<213> Rattus norvegicus
<308> BAA07924
<400> 2038

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
  1               5                  10                  15
Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
             20                  25                  30
Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
         35                  40                  45
Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
     50                  55                  60
Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
 65                  70                  75                  80
Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                 85                  90                  95
Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
             100                105                110
Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
         115                120                125
Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
     130                135                140
Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
 145                150                155                160
Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                 165                170                175
Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
             180                185                190
Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Asn Gln Glu Gly Ser 
         195                200                205
His Pro Gln Pro Leu Gly Gly Pro Glu Pro Gly Pro Tyr Ala Gln Pro 
     210                215                220
Ser Val Asn Thr Pro Leu Pro Asn Leu Gln Asn Gly Pro Ile Tyr Ala 
 225                230                235                240
Arg Val Ile Gln Lys Arg Val Pro Asn Ala Tyr Asp Lys Thr Ala Leu 
                 245                250                255
Ala Leu Glu Val Gly Glu Leu Val Lys Val Thr Lys Ile Asn Val Ser 
             260                265                270
Gly Gln Trp Glu Gly Glu Cys Asn Gly Lys Arg Gly His Phe Pro Phe 
         275                280                285
Thr His Val Arg Leu Leu Asp Gln Gln Asn Pro Glu Glu Asp Phe Ser 
     290                295                300



<210> 2039
<211> 2431
<212> DNA
<213> Homo sapiens
<308> BC008506
<400> 2039

cccgcggct  ccgccgcca  ttcgggcgc  gctgtgaag  tgaaaccgg  gccggtccg  1140
tgggcggcg  gcgccgggg  ccggagggg  gcgcgcggc  gcggcaccc  agcgtttag  1200
cgcggaggc  gccatggcg  gcaacttcg  ctcggagga  cggagtagc  ggtactggg  1260
gcggttgag  cggcaggag  cggtggcgc  gctgcaggg  cagcggcac  gggtgttcc  1320
ggtgcggga  tcgagcacc  gccccgggg  ctatgtgct  agcgtctca  agaactcgc  1380
cgtctccca  tacatcatc  acagcagcg  cccgcgccc  ccggtgcca  cgtcgcccg  1440
ccagcctcc  cccggggtg  gcccctcca  actccgaat  ggagatcaa  agtttgatt  1500
attgcctgc  ttactggaa  tctacaaaa  acactattt  gacactaca  cgttgatag  1560
accagtttc  agatccagg  agggtagtg  agtgattct  aggcaggag  aggcggagt  1620
tgtgcgagc  ctctttgac  ttaatggga  tgatgagga  gatcttccc  ttaagaaag  1680
agacatctt  agaatccgg  acaagcctg  agagcagtg  tggaatgcg  aggacagcg  1740
aggcaagag  gggatgatt  cagtccctt  cgtcgagaa  tatagacct  cctccgcct  1800
agtatcggc  ctgattgga  gtaaccagg  gggttccca  ccacagcca  tgggtgggc  1860
ggagcctgg  ccctatgcc  aacccagcg  caacactcc  ctccctaac  tccagaatg  1920
gcccatata  gccagggtt  tccagaagc  agtccccaa  gcctacgac  agacagcct  1980
ggctttgga  gtcggtgag  tggtaaagg  tacgaagat  aatgtgagt  gtcagtggg  2040
aggggagtg  aatggcaaa  gaggtcact  cccattcac  catgtccgt  tgctggatc  2100
acagaatcc  gatgaggac  tcagctgag  atagttcaa  agttttgct  acagatggg  2160
acaatcttt  ttttttttt  ccaactgcc  tctatacaa  tttcttaca  atgtcaaaa  2220
cagtctagt  tatataagc  ttctgttac  tgtgatatt  tttagactg  actgctcca  2280
tcctagtct  aattaccat  ttcagggta  gaactggag  gcttgtgtg  tagcttctg  2340
attggcaat  ggaggcggt  gtggtcgtg  ctgtgtgta  cagaaggga  aggtatctt  2400
cctcctttc  ctcaggcag  gcaaatcac  c  2431



<210> 2040
<211> 304
<212> PRT
<213> Homo sapiens
<308> P46108
<400> 2040

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
  1               5                  10                  15
Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
             20                  25                  30
Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
         35                  40                  45
Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
     50                  55                  60
Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
 65                  70                  75                  80
Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                 85                  90                  95
Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Trp Asp Thr Thr 
             100                105                110
Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
         115                120                125
Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
     130                135                140
Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
 145                150                155                160
Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                 165                170                175
Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
             180                185                190
Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Asn Gln Glu Gly Ser 
         195                200                205
His Pro Gln Pro Leu Gly Pro Pro Glu Pro Gly Pro Tyr Ala Gln Pro 
     210                215                220
Ser Val Asn Thr Pro Leu Pro Asn Leu Gln Asn Gly Pro Ile Tyr Ala 
 225                230                235                240
Arg Val Ile Gln Lys Arg Val Pro Asn Ala Tyr Asp Lys Thr Ala Leu 
                 245                250                255
Ala Leu Glu Val Gly Glu Leu Val Lys Val Thr Lys Ile Asn Val Ser 
             260                265                270
Gly Gln Trp Glu Gly Gly Cys Asn Gly Lys Arg Gly His Phe Pro Phe 
         275                280                285
Thr His Val Arg Leu Leu Asp Gln Gln Asn Pro Asp Glu Asp Phe Ser 
     290                295                300



<210> 2041
<211> 921
<212> DNA
<213> Rattus norvegicus
<308> D45249
<400> 2041

ctcgcgtgc  gcgttcagc  ccggctctg  ccatggcta  actgagggt  catcctgaa  60
cccaagcca  ggtcgatgt  tttcgtgag  acctgtgta  taagacaga  aacctgctt  120
ggagctatt  tcccaagaa  atctcagag  tggatgcct  cttaaagga  ccagctctc  180
acgaagcca  cctgagcaa  ctgaaggct  cattggaca  cccagtccc  gatcccgtc  240
aggagaaag  gaaggagga  cggaagaag  aacaggaga  ggaagagaa  gacgaaaag  300
agaaagggg  cgaagacga  aaaggtcct  cctgtggtc  agtgaactg  aatgagaag  360
ttgtggtcc  cctgcaacg  ctaaagccc  agatcaagg  tgtcattga  caactcaac  420
tggttacta  ctggttgca  ctacagata  ctcggatag  ggatgggaa  aattttggc  480
tggctgtcc  ggcaaaggt  tttgagctg  tgaccagcc  tcataccaa  ctggaaggc  540
tccaaacgc  gatctctaa  tacttctcc  agaggggtg  tgccgtggc  aaagcagcc  600
agcagcctc  tgtgggtga  tatcggcag  tggtgcatg  gctggacga  gcggaatac  660
aggagatcc  gctgatggt  atggagatc  gtaacgctt  tgctgtgtt  tatgacatc  720
tcctgaaga  ctttgagaa  ctcaagaag  cccgtggag  gacaaaggg  atgatctat  780
gagccccct  tctcgttct  tgatgggta  aacagaaac  ttcctactc  tgactagga  840
ctctagact  cacccagtc  tcttcctgc  ggggtctcc  ccctcactc  gccttccaa  900
cacaataaa  acatagttg  c  921



<210> 2042
<211> 249
<212> PRT
<213> Rattus norvegicus
<308> BAA08206
<400> 2042

Met Ala Thr Leu Arg Val His Pro Glu Ala Gln Ala Lys Val Asp Val 
  1               5                  10                  15
Phe Arg Glu Asp Leu Cys Ser Lys Thr Glu Asn Leu Leu Gly Ser Tyr 
             20                  25                  30
Phe Pro Lys Lys Ile Ser Glu Leu Asp Ala Phe Leu Lys Glu Pro Ala 
         35                  40                  45
Leu Asn Glu Ala Asn Leu Ser Asn Leu Lys Ala Pro Leu Asp Ile Pro 
     50                  55                  60
Val Pro Asp Pro Val Lys Glu Lys Glu Lys Glu Glu Arg Lys Lys Gln 
 65                  70                  75                  80
Gln Glu Lys Glu Glu Lys Asp Glu Lys Lys Lys Gly Asp Glu Asp Asp 
                 85                  90                  95
Lys Gly Pro Pro Cys Gly Pro Val Asn Cys Asn Glu Lys Ile Val Val 
             100                105                110
Leu Leu Gln Arg Leu Lys Pro Glu Ile Lys Asp Val Ile Glu Gln Leu 
         115                120                125
Asn Leu Val Thr Thr Trp Leu Gln Leu Gln Ile Pro Arg Ile Glu Asp 
     130                135                140
Gly Asn Asn Phe Gly Val Ala Val Gln Ala Lys Val Phe Glu Leu Met 
 145                150                155                160
Thr Ser Leu His Thr Lys Leu Glu Gly Phe Gln Thr Gln Ile Ser Lys 
                 165                170                175
Tyr Phe Ser Glu Arg Gly Asp Ala Val Ala Lys Ala Ala Lys Gln Pro 
             180                185                190
His Val Gly Asp Tyr Arg Gln Leu Val His Glu Leu Asp Glu Ala Glu 
         195                200                205
Tyr Gln Glu Ile Arg Leu Met Val Met Glu Ile Arg Asn Ala Tyr Ala 
     210                215                220
Val Leu Tyr Asp Ile Ile Leu Lys Asn Phe Glu Lys Leu Lys Lys Pro 
 225                230                235                240
Arg Gly Glu Thr Lys Gly Met Ile Tyr 
                 245



<210> 2043
<211> 985
<212> DNA
<213> Homo sapiens
<308> NM_006263
<400> 2043

gcggagctg  gtgcgagcg  cctaccgct  tcgctttcc  ttcgcggtg  ccactccac  60
ccttgtgcg  cgctaggcc  cccgtcccg  tcatggcca  gctcagggt  cagcccgag  120
cccaagcca  ggtggatgt  tttcgtgaa  acctctgta  caagacaga  aacctgctc  180
ggagctatt  ccccaagaa  atttctgag  tggatgcat  tttaaagga  ccagctctc  240
atgaagcca  cttgagcaa  ctgaaggcc  cattggaca  cccagtgcc  gatccagtc  300
aggagaaag  gaaagagga  cggaagaaa  agcaggaga  ggaagacaa  gatgaaaag  360
agaaggggg  ggatgaaga  aaaggtcct  cctgtggcc  agtgaactg  aatgaaaag  420
tcgtggtcc  tctgcagcg  ttgaagcct  agatcaagg  tgtcattga  cagctcaac  480
tggtcacca  ctggttgca  ctgcagata  ctcggattg  ggatggtaa  aattttgga  540
tggctgtcc  ggagaaggt  tttgagctg  tgaccagcc  ccacaccaa  ctagaaggc  600
tccacactc  aatctctaa  tatttctct  agcgtggtg  tgcagtgac  aaagcagcc  660
agcagcccc  tgtgggtga  tatcggcag  tggtgcacg  gctggatga  gcagagtac  720
gggacatcc  gctgatggt  atggagatc  gcaatgctt  tgctgtgtt  tatgacatc  780
tcctgaaga  cttcgagaa  ctcaagaag  ccaggggag  aacaaaggg  atgatctat  840
gagagccct  tctcccatt  tgtgatgag  acagcagag  ccttcctgc  ttttactgg  900
gactccaga  tttccccaa  cttgcttct  ttgagattt  tccctcacc  tgcctctca  960
gcacaataa  tatagttat  ccact  985



<210> 2044
<211> 249
<212> PRT
<213> Homo sapiens
<308> Q06323
<400> 2044

Met Ala Met Leu Arg Val Gln Pro Glu Ala Gln Ala Lys Val Asp Val 
  1               5                  10                  15
Phe Arg Glu Asp Leu Cys Thr Lys Thr Glu Asn Leu Leu Gly Ser Tyr 
             20                  25                  30
Phe Pro Lys Lys Ile Ser Glu Leu Asp Ala Phe Leu Lys Glu Pro Ala 
         35                  40                  45
Leu Asn Glu Ala Asn Leu Ser Asn Leu Lys Ala Pro Leu Asp Ile Pro 
     50                  55                  60
Val Pro Asp Pro Val Lys Glu Lys Glu Lys Glu Glu Arg Lys Lys Gln 
 65                  70                  75                  80
Gln Glu Lys Glu Asp Lys Asp Glu Lys Lys Lys Gly Glu Asp Glu Asp 
                 85                  90                  95
Lys Gly Pro Pro Cys Gly Pro Val Asn Cys Asn Glu Lys Ile Val Val 
             100                105                110
Leu Leu Gln Arg Leu Lys Pro Glu Ile Lys Asp Val Ile Glu Gln Leu 
         115                120                125
Asn Leu Val Thr Thr Trp Leu Gln Leu Gln Ile Pro Arg Ile Glu Asp 
     130                135                140
Gly Asn Asn Phe Gly Val Ala Val Gln Glu Lys Val Phe Glu Leu Met 
 145                150                155                160
Thr Ser Leu His Thr Lys Leu Glu Gly Phe His Thr Gln Ile Ser Lys 
                 165                170                175
Tyr Phe Ser Glu Arg Gly Asp Ala Val Thr Lys Ala Ala Lys Gln Pro 
             180                185                190
His Val Gly Asp Tyr Arg Gln Leu Val His Glu Leu Asp Glu Ala Glu 
         195                200                205
Tyr Arg Asp Ile Arg Leu Met Val Met Glu Ile Arg Asn Ala Tyr Ala 
     210                215                220
Val Leu Tyr Asp Ile Ile Leu Lys Asn Phe Glu Lys Leu Lys Lys Pro 
 225                230                235                240
Arg Gly Glu Thr Lys Gly Met Ile Tyr 
                 245



<210> 2045
<211> 921
<212> DNA
<213> Rattus norvegicus
<308> D45249
<400> 2045

ctcgcgtgc  gcgttcagc  ccggctctg  ccatggcta  actgagggt  catcctgaa  60
cccaagcca  ggtcgatgt  tttcgtgag  acctgtgta  taagacaga  aacctgctt  120
ggagctatt  tcccaagaa  atctcagag  tggatgcct  cttaaagga  ccagctctc  180
acgaagcca  cctgagcaa  ctgaaggct  cattggaca  cccagtccc  gatcccgtc  240
aggagaaag  gaaggagga  cggaagaag  aacaggaga  ggaagagaa  gacgaaaag  300
agaaagggg  cgaagacga  aaaggtcct  cctgtggtc  agtgaactg  aatgagaag  360
ttgtggtcc  cctgcaacg  ctaaagccc  agatcaagg  tgtcattga  caactcaac  420
tggttacta  ctggttgca  ctacagata  ctcggatag  ggatgggaa  aattttggc  480
tggctgtcc  ggcaaaggt  tttgagctg  tgaccagcc  tcataccaa  ctggaaggc  540
tccaaacgc  gatctctaa  tacttctcc  agaggggtg  tgccgtggc  aaagcagcc  600
agcagcctc  tgtgggtga  tatcggcag  tggtgcatg  gctggacga  gcggaatac  660
aggagatcc  gctgatggt  atggagatc  gtaacgctt  tgctgtgtt  tatgacatc  720
tcctgaaga  ctttgagaa  ctcaagaag  cccgtggag  gacaaaggg  atgatctat  780
gagccccct  tctcgttct  tgatgggta  aacagaaac  ttcctactc  tgactagga  840
ctctagact  cacccagtc  tcttcctgc  ggggtctcc  ccctcactc  gccttccaa  900
cacaataaa  acatagttg  c  921



<210> 2046
<211> 249
<212> PRT
<213> Rattus norvegicus
<308> BAA08206
<400> 2046

Met Ala Thr Leu Arg Val His Pro Glu Ala Gln Ala Lys Val Asp Val 
  1               5                  10                  15
Phe Arg Glu Asp Leu Cys Ser Lys Thr Glu Asn Leu Leu Gly Ser Tyr 
             20                  25                  30
Phe Pro Lys Lys Ile Ser Glu Leu Asp Ala Phe Leu Lys Glu Pro Ala 
         35                  40                  45
Leu Asn Glu Ala Asn Leu Ser Asn Leu Lys Ala Pro Leu Asp Ile Pro 
     50                  55                  60
Val Pro Asp Pro Val Lys Glu Lys Glu Lys Glu Glu Arg Lys Lys Gln 
 65                  70                  75                  80
Gln Glu Lys Glu Glu Lys Asp Glu Lys Lys Lys Gly Asp Glu Asp Asp 
                 85                  90                  95
Lys Gly Pro Pro Cys Gly Pro Val Asn Cys Asn Glu Lys Ile Val Val 
             100                105                110
Leu Leu Gln Arg Leu Lys Pro Glu Ile Lys Asp Val Ile Glu Gln Leu 
         115                120                125
Asn Leu Val Thr Thr Trp Leu Gln Leu Gln Ile Pro Arg Ile Glu Asp 
     130                135                140
Gly Asn Asn Phe Gly Val Ala Val Gln Ala Lys Val Phe Glu Leu Met 
 145                150                155                160
Thr Ser Leu His Thr Lys Leu Glu Gly Phe Gln Thr Gln Ile Ser Lys 
                 165                170                175
Tyr Phe Ser Glu Arg Gly Asp Ala Val Ala Lys Ala Ala Lys Gln Pro 
             180                185                190
His Val Gly Asp Tyr Arg Gln Leu Val His Glu Leu Asp Glu Ala Glu 
         195                200                205
Tyr Gln Glu Ile Arg Leu Met Val Met Glu Ile Arg Asn Ala Tyr Ala 
     210                215                220
Val Leu Tyr Asp Ile Ile Leu Lys Asn Phe Glu Lys Leu Lys Lys Pro 
 225                230                235                240
Arg Gly Glu Thr Lys Gly Met Ile Tyr 
                 245



<210> 2047
<211> 985
<212> DNA
<213> Homo sapiens
<308> NM_006263
<400> 2047

gcggagctg  gtgcgagcg  cctaccgct  tcgctttcc  ttcgcggtg  ccactccac  60
ccttgtgcg  cgctaggcc  cccgtcccg  tcatggcca  gctcagggt  cagcccgag  120
cccaagcca  ggtggatgt  tttcgtgaa  acctctgta  caagacaga  aacctgctc  180
ggagctatt  ccccaagaa  atttctgag  tggatgcat  tttaaagga  ccagctctc  240
atgaagcca  cttgagcaa  ctgaaggcc  cattggaca  cccagtgcc  gatccagtc  300
aggagaaag  gaaagagga  cggaagaaa  agcaggaga  ggaagacaa  gatgaaaag  360
agaaggggg  ggatgaaga  aaaggtcct  cctgtggcc  agtgaactg  aatgaaaag  420
tcgtggtcc  tctgcagcg  ttgaagcct  agatcaagg  tgtcattga  cagctcaac  480
tggtcacca  ctggttgca  ctgcagata  ctcggattg  ggatggtaa  aattttgga  540
tggctgtcc  ggagaaggt  tttgagctg  tgaccagcc  ccacaccaa  ctagaaggc  600
tccacactc  aatctctaa  tatttctct  agcgtggtg  tgcagtgac  aaagcagcc  660
agcagcccc  tgtgggtga  tatcggcag  tggtgcacg  gctggatga  gcagagtac  720
gggacatcc  gctgatggt  atggagatc  gcaatgctt  tgctgtgtt  tatgacatc  780
tcctgaaga  cttcgagaa  ctcaagaag  ccaggggag  aacaaaggg  atgatctat  840
gagagccct  tctcccatt  tgtgatgag  acagcagag  ccttcctgc  ttttactgg  900
gactccaga  tttccccaa  cttgcttct  ttgagattt  tccctcacc  tgcctctca  960
gcacaataa  tatagttat  ccact  985



<210> 2048
<211> 249
<212> PRT
<213> Homo sapiens
<308> Q06323
<400> 2048

Met Ala Met Leu Arg Val Gln Pro Glu Ala Gln Ala Lys Val Asp Val 
  1               5                  10                  15
Phe Arg Glu Asp Leu Cys Thr Lys Thr Glu Asn Leu Leu Gly Ser Tyr 
             20                  25                  30
Phe Pro Lys Lys Ile Ser Glu Leu Asp Ala Phe Leu Lys Glu Pro Ala 
         35                  40                  45
Leu Asn Glu Ala Asn Leu Ser Asn Leu Lys Ala Pro Leu Asp Ile Pro 
     50                  55                  60
Val Pro Asp Pro Val Lys Glu Lys Glu Lys Glu Glu Arg Lys Lys Gln 
 65                  70                  75                  80
Gln Glu Lys Glu Asp Lys Asp Glu Lys Lys Lys Gly Glu Asp Glu Asp 
                 85                  90                  95
Lys Gly Pro Pro Cys Gly Pro Val Asn Cys Asn Glu Lys Ile Val Val 
             100                105                110
Leu Leu Gln Arg Leu Lys Pro Glu Ile Lys Asp Val Ile Glu Gln Leu 
         115                120                125
Asn Leu Val Thr Thr Trp Leu Gln Leu Gln Ile Pro Arg Ile Glu Asp 
     130                135                140
Gly Asn Asn Phe Gly Val Ala Val Gln Glu Lys Val Phe Glu Leu Met 
 145                150                155                160
Thr Ser Leu His Thr Lys Leu Glu Gly Phe His Thr Gln Ile Ser Lys 
                 165                170                175
Tyr Phe Ser Glu Arg Gly Asp Ala Val Thr Lys Ala Ala Lys Gln Pro 
             180                185                190
His Val Gly Asp Tyr Arg Gln Leu Val His Glu Leu Asp Glu Ala Glu 
         195                200                205
Tyr Arg Asp Ile Arg Leu Met Val Met Glu Ile Arg Asn Ala Tyr Ala 
     210                215                220
Val Leu Tyr Asp Ile Ile Leu Lys Asn Phe Glu Lys Leu Lys Lys Pro 
 225                230                235                240
Arg Gly Glu Thr Lys Gly Met Ile Tyr 
                 245



<210> 2049
<211> 2669
<212> DNA
<213> Rattus norvegicus
<308> D45252
<400> 2049

ggcagtgcg  taggctgtc  gtcaggtaa  gggctggcc  gccggtggt  cagagctgt  60
ctgtcatga  cgagggcac  tgtctgcgg  gtcgtgggg  accctataa  actgagccc  120
ccaccgatc  cacccgctg  cggctccat  atgagttgg  tcggcagag  tggacttat  180
atcaagcgg  ggaggaccc  ggtcgagaa  agacggggc  agaggccca  tctttggga  240
tggacacaa  aagttattt  aagaactta  ctaaagctc  aacagccca  gagggggcc  300
tgaacggag  aacctttta  gccaagctg  aggctgagg  tggacactg  gctggtgat  360
atggtggtc  actcttcct  ttgccaggt  tcctgatta  gtgtcacat  gcacacatc  420
ccctgccgg  tggatacag  gaggaaatg  tacggtact  gcgctcagt  cagcttccc  480
atggcggct  gggcttgca  attgaggac  agtccacgg  gtttgggac  gccctgagc  540
atgtgtctc  cagaatcct  ggtattgga  ctgatgatc  tgaccttgt  cgtgctcgg  600
acattcttc  caaaaaagg  ggtgcagtg  gcatccctt  ctgggggaa  ttctggctg  660
ctgtcctga  tgtttacag  tgggaagga  tcaataccc  cttccctga  atgtggctg  720
ttcctgaat  gtttcccgc  catccctca  ctctgtggt  tcactgccg  caggtctat  780
tgcccatga  ctactgcta  gccactcgg  taagtgcct  agaggaccc  ctggttcag  840
gcctccgcc  ggaactcta  gtggaggat  atgccagca  cgattggcc  gcacagaag  900
acaacgtgt  ccccgatga  atgtacacg  cacacagtt  gctgctgca  gtggtgtat  960
gactcctca  cctgtatga  cgtttccac  gtaccagcc  gcggaagtg  gccatccag  1020
tgctgtatg  acatgttgc  gctgatgat  ggttcacaa  atgcatcag  attggcccg  1080
tctcaaaaa  tgtcaacat  cttattcgt  ggtcagtgg  cggaccatc  tcccctgcc  1140
tccaggagc  cgtctcgag  atcaaagat  atctttggc  gggccttga  ggcatgaaa  1200
tgcagggca  caatggatc  cagacctgg  acacttcat  tgctgtcca  gccctgctg  1260
aggcaggtg  acaccgaag  cctgagttt  tgccctgcc  gcagaaggc  cacgagttc  1320
tgcggcttt  ccaggtccc  gacaacaat  ctgactacc  gaagtatta  cgccatatg  1380
acaagggtg  tttcccctt  agcacactg  actgtggct  gatcgttgc  gactgcacg  1440
ccgaggctt  gaaggctgt  ctgctcctg  aggagcggt  tccctcaat  accgagcat  1500
tcccccaag  gcgactcta  aatgctgtg  ctgtgttgt  gagcatgag  aattccgat  1560
gagggtttg  tacctatga  actaagcgt  gcgggtatt  gctggagct  ctgaacccc  1620
cagaggtct  tggagacat  atgattgac  acacgtatg  agagtgtac  tccgcagtg  1680
tgcaggccc  gaggcactt  cgcgagtac  tcccagacc  cagggctac  gagagcagg  1740
agaccctca  tcaaggcct  gacttctgc  gaaagaagc  gagagcgga  ggctcgtgg  1800
agggctcct  gggggtttg  ttcacctat  gcacctggt  tggcttgga  gcattcgct  1860
gcatgggac  tatctacca  aataggact  cttgtgcag  agtagctca  gcctgccac  1920
tcctcctgt  gcggcagat  gcggatggg  gctgggggg  ggactttga  tcctgtgag  1980
agcgacggt  cgtgcagag  gccgggtcc  aggtccata  tacgtgctg  gccctgctg  2040
gtttgatgg  tgtcaggca  cccgacatc  ctgctcagg  gagaggaat  agatgtctg  2100
tagggaaac  gttccccaa  ggagaatgg  ctcaggaga  catctctgg  gtcttcaac  2160
agtcctgtg  catcagcta  accaattac  gaaacatct  ccccatctg  gccctgggc  2220
gcttctcca  cctgtatcc  gacaatacc  ttgctggcc  catttgagc  tgtgtgcgc  2280
tgtgcggca  ctggccagc  tcagcactg  acaggccca  gcagcccgg  ttctcagct  2340
ggtgataag  gtcctccta  cccactttg  catggttct  tatttctgt  gacatgagg  2400
tggggatag  gttcagagt  ggtgtctag  cactgggtc  gcatgctca  agaaaggct  2460
aatggagga  gcaggcccc  tgctcattg  gtcctgagc  gtgtctgtt  tcccagaca  2520
ttacccatg  ctgcatcac  gcacgaaat  ccagttttc  agaaaggaa  tacaaactc  2580
ctctgtact  aaaatgcta  taaaagtcg  ttgaatgat  accaactcc  ttaataaac  2640
gaccctggg  tgatggccc  gtagtaaag  2669



<210> 2050
<211> 733
<212> PRT
<213> Rattus norvegicus
<308> P48450
<400> 2050

Met Thr Glu Gly Thr Cys Leu Arg Arg Arg Gly Gly Pro Tyr Lys Thr 
  1               5                  10                  15
Glu Pro Ala Thr Asp Leu Thr Arg Trp Arg Leu His Asn Glu Leu Gly 
             20                  25                  30
Arg Gln Arg Trp Thr Tyr Tyr Gln Ala Glu Glu Asp Pro Gly Arg Glu 
         35                  40                  45
Gln Thr Gly Leu Glu Ala His Ser Leu Gly Leu Asp Thr Thr Ser Tyr 
     50                  55                  60
Phe Lys Asn Leu Pro Lys Ala Gln Thr Ala His Glu Gly Ala Leu Asn 
 65                  70                  75                  80
Gly Val Thr Phe Tyr Ala Lys Leu Gln Ala Glu Asp Gly His Trp Ala 
                 85                  90                  95
Gly Asp Tyr Gly Gly Pro Leu Phe Leu Leu Pro Gly Leu Leu Ile Thr 
             100                105                110
Cys His Ile Ala His Ile Pro Leu Pro Ala Gly Tyr Arg Glu Glu Met 
         115                120                125
Val Arg Tyr Leu Arg Ser Val Gln Leu Pro Asp Gly Gly Trp Gly Leu 
     130                135                140
His Ile Glu Asp Lys Ser Thr Val Phe Gly Thr Ala Leu Ser Tyr Val 
 145                150                155                160
Ser Leu Arg Ile Leu Gly Ile Gly Pro Asp Asp Pro Asp Leu Val Arg 
                 165                170                175
Ala Arg Asn Ile Leu His Lys Lys Gly Gly Ala Val Gly Ile Pro Ser 
             180                185                190
Trp Gly Lys Phe Trp Leu Ala Val Leu Asn Val Tyr Ser Trp Glu Gly 
         195                200                205
Ile Asn Thr Leu Phe Pro Glu Met Trp Leu Leu Pro Glu Trp Phe Pro 
     210                215                220
Ala His Pro Ser Thr Leu Trp Cys His Cys Arg Gln Val Tyr Leu Pro 
 225                230                235                240
Met Ser Tyr Cys Tyr Ala Thr Arg Leu Ser Ala Ser Glu Asp Pro Leu 
                 245                250                255
Val Gln Ser Leu Arg Gln Glu Leu Tyr Val Glu Asp Tyr Ala Ser Ile 
             260                265                270
Asp Trp Pro Ala Gln Lys Asn Asn Val Cys Pro Asp Asp Met Tyr Thr 
         275                280                285
Pro His Ser Trp Leu Leu His Val Val Tyr Gly Leu Leu Asn Leu Tyr 
     290                295                300
Glu Arg Phe His Ser Thr Ser Leu Arg Lys Trp Ala Ile Gln Leu Leu 
 305                310                315                320
Tyr Glu His Val Ala Ala Asp Asp Arg Phe Thr Lys Cys Ile Ser Ile 
                 325                330                335
Gly Pro Ile Ser Lys Thr Val Asn Met Leu Ile Arg Trp Ser Val Asp 
             340                345                350
Gly Pro Ser Ser Pro Ala Phe Gln Glu His Val Ser Arg Ile Lys Asp 
         355                360                365
Tyr Leu Trp Leu Gly Leu Asp Gly Met Lys Met Gln Gly Thr Asn Gly 
     370                375                380
Ser Gln Thr Trp Asp Thr Ser Phe Ala Val Gln Ala Leu Leu Glu Ala 
 385                390                395                400
Gly Ala His Arg Arg Pro Glu Phe Leu Pro Cys Leu Gln Lys Ala His 
                 405                410                415
Glu Phe Leu Arg Leu Ser Gln Val Pro Asp Asn Asn Pro Asp Tyr Gln 
             420                425                430
Lys Tyr Tyr Arg His Met His Lys Gly Gly Phe Pro Phe Ser Thr Leu 
         435                440                445
Asp Cys Gly Trp Ile Val Ala Asp Cys Thr Ala Glu Ala Leu Lys Ala 
     450                455                460
Val Leu Leu Leu Gln Glu Arg Cys Pro Ser Ile Thr Glu His Val Pro 
 465                470                475                480
Gln Glu Arg Leu Tyr Asn Ala Val Ala Val Leu Leu Ser Met Arg Asn 
                 485                490                495
Ser Asp Gly Gly Phe Ala Thr Tyr Glu Thr Lys Arg Gly Gly Tyr Leu 
             500                505                510
Leu Glu Leu Leu Asn Pro Ser Glu Val Phe Gly Asp Ile Met Ile Asp 
         515                520                525
Tyr Thr Tyr Val Glu Cys Thr Ser Ala Val Met Gln Ala Leu Arg His 
     530                535                540
Phe Arg Glu Tyr Phe Pro Asp His Arg Ala Thr Glu Ser Arg Glu Thr 
 545                550                555                560
Leu Asn Gln Gly Leu Asp Phe Cys Arg Lys Lys Gln Arg Ala Asp Gly 
                 565                570                575
Ser Trp Glu Gly Ser Trp Gly Val Cys Phe Thr Tyr Gly Thr Trp Phe 
             580                585                590
Gly Leu Glu Ala Phe Ala Cys Met Gly His Ile Tyr Gln Asn Arg Thr 
         595                600                605
Ala Cys Ala Glu Val Ala Gln Ala Cys His Phe Leu Leu Ser Arg Gln 
     610                615                620
Met Ala Asp Gly Gly Trp Gly Glu Asp Phe Glu Ser Cys Glu Gln Arg 
 625                630                635                640
Arg Tyr Val Gln Ser Ala Gly Ser Gln Val His Ser Thr Cys Trp Ala 
                 645                650                655
Leu Leu Gly Leu Met Ala Val Arg His Pro Asp Ile Ser Ala Gln Glu 
             660                665                670
Arg Gly Ile Arg Cys Leu Leu Gly Lys Gln Phe Pro Asn Gly Glu Trp 
         675                680                685
Pro Gln Glu Asn Ile Ser Gly Val Phe Asn Lys Ser Cys Ala Ile Ser 
     690                695                700
Tyr Thr Asn Tyr Arg Asn Ile Phe Pro Ile Trp Ala Leu Gly Arg Phe 
 705                710                715                720
Ser Ser Leu Tyr Pro Asp Asn Thr Leu Ala Gly His Ile 
                 725                730



<210> 2051
<211> 3206
<212> DNA
<213> Homo sapiens
<308> NM_002340
<400> 2051

cccttgcct  ctgctcatg  gtgtggaga  tgatattct  gaagactga  aggcagatt  60
actattaac  aacacatag  ctgtggccc  gcaaagcca  cccaatccc  gcacaaggg  120
aaaaggcca  cattagagc  ctgcagcag  aatgacgga  ggcacgtgt  tgcggcgcc  180
agggggccc  tacaagacc  agcccgcca  cgacctcgg  cgctggcga  tcaactgcg  240
gaggggccg  cagacgtgg  cctacctgc  ggacgagcg  gccggccgc  agcagaccg  300
cctggaagc  tacgccctg  ggctggaca  caagaatta  tttaaggac  tgcccaaag  360
ccacaccgc  tttgagggg  ctctgaacg  gatgacatt  tacgtgggg  tgcaggctg  420
ggatgggca  tggacgggt  attatggtg  cccactttt  ctcctgcca  gcctcctga  480
cacttgcca  gtggcacgc  tccctctgc  agccggata  agagaagag  ttgtgcggt  540
cctgcggtc  gtgcagctc  ctgacggtg  ctggggcct  cacattgag  ataagtcca  600
cgtgtttgg  actgcgctc  actatgtgt  tctcagaat  ctgggtgtt  ggcctgacg  660
tcctgacct  gtacgagcc  ggaacattc  tcacaagaa  ggtggtgct  tggccatcc  720
ctcctgggg  aagttctgg  tggctgtcc  gaatgttta  agctgggaa  gcctcaata  780
cctgttccc  gagatgtgg  tgtttcctg  ctgggcacc  gcacacccc  ccacactct  840
gtgccactg  cggcaggtg  acctgccca  gagctactg  tacgccgtt  ggctgagtg  900
cgcggaaga  ccgctggtc  agagcctcc  ccaggagct  tatgtggag  acttcgcca  960
cattgactg  ctggcgcag  ggaacaacg  ggcccccga  gagctgtac  cgccccaca  1020
ctggctgct  cgcgtggta  atgcgctcc  caacctgta  gagcaccac  acagtgccc  1080
cctgcggca  cgggccgtg  agaagctgt  tgaacacat  gtggccgac  accgattca  1140
caagagcat  agcatcggc  cgatctcga  aaccatcaa  atgcttgtg  gctggtatg  1200
ggacgggcc  gcctccact  ccttccagg  gcatgtctc  agaatcccg  actatctct  1260
gatgggcct  gacggcatg  aaatgcagg  caccaacgg  tcacagatc  gggacaccg  1320
attcgccat  caggctctg  ttgaggcgg  cgggcacca  aggcccgag  tttcgtcct  1380
cctgcagaa  gctcatgag  tcctgaggc  ctcacaggt  ccagataac  ctcccgact  1440
ccagaagta  taccgccag  tgcgcaagg  tggcttctc  ttcagtacg  tggactgcg  1500
ctggatcgt  tctgactgc  cggctgagg  cttgaaggc  gtgctgctc  tgcaggaga  1560
gtgtcccca  gtcaccgag  acatcccca  agaacggct  tgcgatgct  tggctgtgc  1620
gctgaacat  agaaatcca  atggagggt  cgccaccta  gagaccaag  gtggggggc  1680
cttgctgga  ctgctgaac  cctcggagg  cttcgggga  atcatgatt  actacacct  1740
tgtggagtg  acctcagcc  tgatgcagg  gcttaagta  ttccacaag  gtttcccgg  1800
gcacagggc  gcggagatc  gggagaccc  cacgcaggg  ttagagttc  gtcggcggc  1860
gcagagggc  gatggctcc  gggaaggct  ctggggagt  tgcttcacc  acggcacct  1920
gtttggcct  gaggccttc  cctgtatgg  gcagaccta  cgagatggg  ctgcctgtg  1980
agaggtctc  cgggcctgt  acttcctgc  gtcccggca  atggcagac  gaggctggg  2040
ggaggactt  gagtcctgc  aggagcggc  ttatttgca  agtgcccag  cccagatcc  2100
taacacatg  tgggccatg  tggggctga  ggccgttcg  catcctgac  tcgaggccc  2160
ggagagagg  gtccggtgt  tacttgaga  acagctccc  aatggcgac  ggccgcagg  2220
aaacattgc  ggggtcttc  acaagtcct  tgccatctc  tacacgagc  acaggaaca  2280
cttccccat  tgggccctc  gccgcttct  ccagctgta  cctgagaga  cccttgctg  2340
ccacccctg  gaacatgcc  acctgctgg  tgccgtctg  gcgttccag  gaggccaag  2400
ggtcctggc  gggttgggg  gccctccca  aaccctgtc  tgggctcca  cccctcaac  2460
tctatctca  agatgtgaa  ctgggggcc  ggctggagg  agggatggg  acagggtgg  2520
tggcttaga  tcttgattt  tactgtagg  tcatttctg  aagtagctt  tcgggcttg  2580
gtgaggaag  gggcacagg  gccgtgacc  ctgaggagg  acagcgcct  ctgccacct  2640
tgggcacgg  ctcaaggta  tgaggctag  aggtttttt  tgaccaata  ctgagttct  2700
gggagagga  cagctgtgc  tgtgtgatt  cttagtgtc  agtgggctc  gggctgggg  2760
cggccctgg  caggcttct  ctgcacctt  tgtctgctg  gctgaggga  acgagggca  2820
ccctgtgac  atggcaggt  gtgtgcatc  gtgaatagc  cagtgcggg  gttgctcat  2880
gagcatcct  aggccgtgc  gcagggagc  ccatgcccc  gggtcgtga  cttgcctgc  2940
tatggggtg  tgtcatgga  cctcatgcc  ctgggtcgt  agctcgcct  agtatgggg  3000
ggtgtcatg  agccgcata  ccctgggtt  tgagctcgc  tgcatatgc  gggtctgtc  3060
tggaacatc  caagtctgt  cagcaggga  ccccatgcc  ctgggacat  aacccacct  3120
cgtggaatg  tgtttgtga  gtgtctaca  ggtttatag  agtcttgtg  acacagaaa  3180
gcacagggg  cacttacgg  cacaga  3206



<210> 2052
<211> 732
<212> PRT
<213> Homo sapiens
<308> P48449
<400> 2052

Met Thr Glu Gly Thr Cys Leu Arg Arg Arg Gly Gly Pro Tyr Lys Thr 
  1               5                  10                  15
Glu Pro Ala Thr Asp Leu Gly Arg Trp Arg Leu Asn Cys Glu Arg Gly 
             20                  25                  30
Arg Gln Thr Trp Thr Tyr Leu Gln Asp Glu Arg Ala Gly Arg Glu Gln 
         35                  40                  45
Thr Gly Leu Glu Ala Tyr Ala Leu Gly Leu Asp Thr Lys Asn Tyr Phe 
     50                  55                  60
Lys Asp Leu Pro Lys Ala His Thr Ala Phe Glu Gly Ala Leu Asn Gly 
 65                  70                  75                  80
Met Thr Phe Tyr Val Gly Leu Gln Ala Glu Asp Gly His Trp Thr Gly 
                 85                  90                  95
Asp Tyr Gly Gly Pro Leu Phe Leu Leu Pro Gly Leu Leu Ile Thr Cys 
             100                105                110
His Val Ala Arg Ile Pro Leu Pro Ala Gly Tyr Arg Glu Glu Ile Val 
         115                120                125
Arg Tyr Leu Arg Ser Val Gln Leu Pro Asp Gly Gly Trp Gly Leu His 
     130                135                140
Ile Glu Asp Lys Ser Thr Val Phe Gly Thr Ala Leu Asn Tyr Val Ser 
 145                150                155                160
Leu Arg Ile Leu Gly Val Gly Pro Asp Asp Pro Asp Leu Val Arg Ala 
                 165                170                175
Arg Asn Ile Leu His Lys Lys Gly Gly Ala Val Ala Ile Pro Ser Trp 
             180                185                190
Gly Lys Phe Trp Leu Ala Val Leu Asn Val Tyr Ser Trp Glu Gly Leu 
         195                200                205
Asn Thr Leu Phe Pro Glu Met Trp Leu Phe Pro Asp Trp Ala Pro Ala 
     210                215                220
His Pro Ser Thr Leu Trp Cys His Cys Arg Gln Val Tyr Leu Pro Met 
 225                230                235                240
Ser Tyr Cys Tyr Ala Val Arg Leu Ser Ala Ala Glu Asp Pro Leu Val 
                 245                250                255
Gln Ser Leu Arg Gln Glu Leu Tyr Val Glu Asp Phe Ala Ser Ile Asp 
             260                265                270
Trp Leu Ala Gln Arg Asn Asn Val Ala Pro Asp Glu Leu Tyr Thr Pro 
         275                280                285
His Ser Trp Leu Leu Arg Val Val Tyr Ala Leu Leu Asn Leu Tyr Glu 
     290                295                300
His His His Ser Ala His Leu Arg Gln Arg Ala Val Gln Lys Leu Tyr 
 305                310                315                320
Glu His Ile Val Ala Asp Asp Arg Phe Thr Lys Ser Ile Ser Ile Gly 
                 325                330                335
Pro Ile Ser Lys Thr Ile Asn Met Leu Val Arg Trp Tyr Val Asp Gly 
             340                345                350
Pro Ala Ser Thr Ala Phe Gln Glu His Val Ser Arg Ile Pro Asp Tyr 
         355                360                365
Leu Trp Met Gly Leu Asp Gly Met Lys Met Gln Gly Thr Asn Gly Ser 
     370                375                380
Gln Ile Trp Asp Thr Ala Phe Ala Ile Gln Ala Leu Leu Glu Ala Gly 
 385                390                395                400
Gly His His Arg Pro Glu Phe Ser Ser Cys Leu Gln Lys Ala His Glu 
                 405                410                415
Phe Leu Arg Leu Ser Gln Val Pro Asp Asn Pro Pro Asp Tyr Gln Lys 
             420                425                430
Tyr Tyr Arg Gln Met Arg Lys Gly Gly Phe Ser Phe Ser Thr Leu Asp 
         435                440                445
Cys Gly Trp Ile Val Ser Asp Cys Thr Ala Glu Ala Leu Lys Ala Val 
     450                455                460
Leu Leu Leu Gln Glu Lys Cys Pro His Val Thr Glu His Ile Pro Arg 
 465                470                475                480
Glu Arg Leu Cys Asp Ala Val Ala Val Leu Leu Asn Met Arg Asn Pro 
                 485                490                495
Asp Gly Gly Phe Ala Thr Tyr Glu Thr Lys Arg Gly Gly His Leu Leu 
             500                505                510
Glu Leu Leu Asn Pro Ser Glu Val Phe Gly Asp Ile Met Ile Asp Tyr 
         515                520                525
Thr Tyr Val Glu Cys Thr Ser Ala Val Met Gln Ala Leu Lys Tyr Phe 
     530                535                540
His Lys Arg Phe Pro Glu His Arg Ala Ala Glu Ile Arg Glu Thr Leu 
 545                550                555                560
Thr Gln Gly Leu Glu Phe Cys Arg Arg Gln Gln Arg Ala Asp Gly Ser 
                 565                570                575
Trp Glu Gly Ser Trp Gly Val Cys Phe Thr Tyr Gly Thr Trp Phe Gly 
             580                585                590
Leu Glu Ala Phe Ala Cys Met Gly Gln Thr Tyr Arg Asp Gly Thr Ala 
         595                600                605
Cys Ala Glu Val Ser Arg Ala Cys Asp Phe Leu Leu Ser Arg Gln Met 
     610                615                620
Ala Asp Gly Gly Trp Gly Glu Asp Phe Glu Ser Cys Glu Glu Arg Arg 
 625                630                635                640
Tyr Leu Gln Ser Ala Gln Ser Gln Ile His Asn Thr Cys Trp Ala Met 
                 645                650                655
Met Gly Leu Met Ala Val Arg His Pro Asp Ile Glu Ala Gln Glu Arg 
             660                665                670
Gly Val Arg Cys Leu Leu Glu Lys Gln Leu Pro Asn Gly Asp Trp Pro 
         675                680                685
Gln Glu Asn Ile Ala Gly Val Phe Asn Lys Ser Cys Ala Ile Ser Tyr 
     690                695                700
Thr Ser Tyr Arg Asn Ile Phe Pro Ile Trp Ala Leu Gly Arg Phe Ser 
 705                710                715                720
Gln Leu Tyr Pro Glu Arg Ala Leu Ala Gly His Pro 
                 725                730



<210> 2053
<211> 2669
<212> DNA
<213> Rattus norvegicus
<308> D45252
<400> 2053

ggcagtgcg  taggctgtc  gtcaggtaa  gggctggcc  gccggtggt  cagagctgt  60
ctgtcatga  cgagggcac  tgtctgcgg  gtcgtgggg  accctataa  actgagccc  120
ccaccgatc  cacccgctg  cggctccat  atgagttgg  tcggcagag  tggacttat  180
atcaagcgg  ggaggaccc  ggtcgagaa  agacggggc  agaggccca  tctttggga  240
tggacacaa  aagttattt  aagaactta  ctaaagctc  aacagccca  gagggggcc  300
tgaacggag  aacctttta  gccaagctg  aggctgagg  tggacactg  gctggtgat  360
atggtggtc  actcttcct  ttgccaggt  tcctgatta  gtgtcacat  gcacacatc  420
ccctgccgg  tggatacag  gaggaaatg  tacggtact  gcgctcagt  cagcttccc  480
atggcggct  gggcttgca  attgaggac  agtccacgg  gtttgggac  gccctgagc  540
atgtgtctc  cagaatcct  ggtattgga  ctgatgatc  tgaccttgt  cgtgctcgg  600
acattcttc  caaaaaagg  ggtgcagtg  gcatccctt  ctgggggaa  ttctggctg  660
ctgtcctga  tgtttacag  tgggaagga  tcaataccc  cttccctga  atgtggctg  720
ttcctgaat  gtttcccgc  catccctca  ctctgtggt  tcactgccg  caggtctat  780
tgcccatga  ctactgcta  gccactcgg  taagtgcct  agaggaccc  ctggttcag  840
gcctccgcc  ggaactcta  gtggaggat  atgccagca  cgattggcc  gcacagaag  900
acaacgtgt  ccccgatga  atgtacacg  cacacagtt  gctgctgca  gtggtgtat  960
gactcctca  cctgtatga  cgtttccac  gtaccagcc  gcggaagtg  gccatccag  1020
tgctgtatg  acatgttgc  gctgatgat  ggttcacaa  atgcatcag  attggcccg  1080
tctcaaaaa  tgtcaacat  cttattcgt  ggtcagtgg  cggaccatc  tcccctgcc  1140
tccaggagc  cgtctcgag  atcaaagat  atctttggc  gggccttga  ggcatgaaa  1200
tgcagggca  caatggatc  cagacctgg  acacttcat  tgctgtcca  gccctgctg  1260
aggcaggtg  acaccgaag  cctgagttt  tgccctgcc  gcagaaggc  cacgagttc  1320
tgcggcttt  ccaggtccc  gacaacaat  ctgactacc  gaagtatta  cgccatatg  1380
acaagggtg  tttcccctt  agcacactg  actgtggct  gatcgttgc  gactgcacg  1440
ccgaggctt  gaaggctgt  ctgctcctg  aggagcggt  tccctcaat  accgagcat  1500
tcccccaag  gcgactcta  aatgctgtg  ctgtgttgt  gagcatgag  aattccgat  1560
gagggtttg  tacctatga  actaagcgt  gcgggtatt  gctggagct  ctgaacccc  1620
cagaggtct  tggagacat  atgattgac  acacgtatg  agagtgtac  tccgcagtg  1680
tgcaggccc  gaggcactt  cgcgagtac  tcccagacc  cagggctac  gagagcagg  1740
agaccctca  tcaaggcct  gacttctgc  gaaagaagc  gagagcgga  ggctcgtgg  1800
agggctcct  gggggtttg  ttcacctat  gcacctggt  tggcttgga  gcattcgct  1860
gcatgggac  tatctacca  aataggact  cttgtgcag  agtagctca  gcctgccac  1920
tcctcctgt  gcggcagat  gcggatggg  gctgggggg  ggactttga  tcctgtgag  1980
agcgacggt  cgtgcagag  gccgggtcc  aggtccata  tacgtgctg  gccctgctg  2040
gtttgatgg  tgtcaggca  cccgacatc  ctgctcagg  gagaggaat  agatgtctg  2100
tagggaaac  gttccccaa  ggagaatgg  ctcaggaga  catctctgg  gtcttcaac  2160
agtcctgtg  catcagcta  accaattac  gaaacatct  ccccatctg  gccctgggc  2220
gcttctcca  cctgtatcc  gacaatacc  ttgctggcc  catttgagc  tgtgtgcgc  2280
tgtgcggca  ctggccagc  tcagcactg  acaggccca  gcagcccgg  ttctcagct  2340
ggtgataag  gtcctccta  cccactttg  catggttct  tatttctgt  gacatgagg  2400
tggggatag  gttcagagt  ggtgtctag  cactgggtc  gcatgctca  agaaaggct  2460
aatggagga  gcaggcccc  tgctcattg  gtcctgagc  gtgtctgtt  tcccagaca  2520
ttacccatg  ctgcatcac  gcacgaaat  ccagttttc  agaaaggaa  tacaaactc  2580
ctctgtact  aaaatgcta  taaaagtcg  ttgaatgat  accaactcc  ttaataaac  2640
gaccctggg  tgatggccc  gtagtaaag  2669



<210> 2054
<211> 733
<212> PRT
<213> Rattus norvegicus
<308> P48450
<400> 2054

Met Thr Glu Gly Thr Cys Leu Arg Arg Arg Gly Gly Pro Tyr Lys Thr 
  1               5                  10                  15
Glu Pro Ala Thr Asp Leu Thr Arg Trp Arg Leu His Asn Glu Leu Gly 
             20                  25                  30
Arg Gln Arg Trp Thr Tyr Tyr Gln Ala Glu Glu Asp Pro Gly Arg Glu 
         35                  40                  45
Gln Thr Gly Leu Glu Ala His Ser Leu Gly Leu Asp Thr Thr Ser Tyr 
     50                  55                  60
Phe Lys Asn Leu Pro Lys Ala Gln Thr Ala His Glu Gly Ala Leu Asn 
 65                  70                  75                  80
Gly Val Thr Phe Tyr Ala Lys Leu Gln Ala Glu Asp Gly His Trp Ala 
                 85                  90                  95
Gly Asp Tyr Gly Gly Pro Leu Phe Leu Leu Pro Gly Leu Leu Ile Thr 
             100                105                110
Cys His Ile Ala His Ile Pro Leu Pro Ala Gly Tyr Arg Glu Glu Met 
         115                120                125
Val Arg Tyr Leu Arg Ser Val Gln Leu Pro Asp Gly Gly Trp Gly Leu 
     130                135                140
His Ile Glu Asp Lys Ser Thr Val Phe Gly Thr Ala Leu Ser Tyr Val 
 145                150                155                160
Ser Leu Arg Ile Leu Gly Ile Gly Pro Asp Asp Pro Asp Leu Val Arg 
                 165                170                175
Ala Arg Asn Ile Leu His Lys Lys Gly Gly Ala Val Gly Ile Pro Ser 
             180                185                190
Trp Gly Lys Phe Trp Leu Ala Val Leu Asn Val Tyr Ser Trp Glu Gly 
         195                200                205
Ile Asn Thr Leu Phe Pro Glu Met Trp Leu Leu Pro Glu Trp Phe Pro 
     210                215                220
Ala His Pro Ser Thr Leu Trp Cys His Cys Arg Gln Val Tyr Leu Pro 
 225                230                235                240
Met Ser Tyr Cys Tyr Ala Thr Arg Leu Ser Ala Ser Glu Asp Pro Leu 
                 245                250                255
Val Gln Ser Leu Arg Gln Glu Leu Tyr Val Glu Asp Tyr Ala Ser Ile 
             260                265                270
Asp Trp Pro Ala Gln Lys Asn Asn Val Cys Pro Asp Asp Met Tyr Thr 
         275                280                285
Pro His Ser Trp Leu Leu His Val Val Tyr Gly Leu Leu Asn Leu Tyr 
     290                295                300
Glu Arg Phe His Ser Thr Ser Leu Arg Lys Trp Ala Ile Gln Leu Leu 
 305                310                315                320
Tyr Glu His Val Ala Ala Asp Asp Arg Phe Thr Lys Cys Ile Ser Ile 
                 325                330                335
Gly Pro Ile Ser Lys Thr Val Asn Met Leu Ile Arg Trp Ser Val Asp 
             340                345                350
Gly Pro Ser Ser Pro Ala Phe Gln Glu His Val Ser Arg Ile Lys Asp 
         355                360                365
Tyr Leu Trp Leu Gly Leu Asp Gly Met Lys Met Gln Gly Thr Asn Gly 
     370                375                380
Ser Gln Thr Trp Asp Thr Ser Phe Ala Val Gln Ala Leu Leu Glu Ala 
 385                390                395                400
Gly Ala His Arg Arg Pro Glu Phe Leu Pro Cys Leu Gln Lys Ala His 
                 405                410                415
Glu Phe Leu Arg Leu Ser Gln Val Pro Asp Asn Asn Pro Asp Tyr Gln 
             420                425                430
Lys Tyr Tyr Arg His Met His Lys Gly Gly Phe Pro Phe Ser Thr Leu 
         435                440                445
Asp Cys Gly Trp Ile Val Ala Asp Cys Thr Ala Glu Ala Leu Lys Ala 
     450                455                460
Val Leu Leu Leu Gln Glu Arg Cys Pro Ser Ile Thr Glu His Val Pro 
 465                470                475                480
Gln Glu Arg Leu Tyr Asn Ala Val Ala Val Leu Leu Ser Met Arg Asn 
                 485                490                495
Ser Asp Gly Gly Phe Ala Thr Tyr Glu Thr Lys Arg Gly Gly Tyr Leu 
             500                505                510
Leu Glu Leu Leu Asn Pro Ser Glu Val Phe Gly Asp Ile Met Ile Asp 
         515                520                525
Tyr Thr Tyr Val Glu Cys Thr Ser Ala Val Met Gln Ala Leu Arg His 
     530                535                540
Phe Arg Glu Tyr Phe Pro Asp His Arg Ala Thr Glu Ser Arg Glu Thr 
 545                550                555                560
Leu Asn Gln Gly Leu Asp Phe Cys Arg Lys Lys Gln Arg Ala Asp Gly 
                 565                570                575
Ser Trp Glu Gly Ser Trp Gly Val Cys Phe Thr Tyr Gly Thr Trp Phe 
             580                585                590
Gly Leu Glu Ala Phe Ala Cys Met Gly His Ile Tyr Gln Asn Arg Thr 
         595                600                605
Ala Cys Ala Glu Val Ala Gln Ala Cys His Phe Leu Leu Ser Arg Gln 
     610                615                620
Met Ala Asp Gly Gly Trp Gly Glu Asp Phe Glu Ser Cys Glu Gln Arg 
 625                630                635                640
Arg Tyr Val Gln Ser Ala Gly Ser Gln Val His Ser Thr Cys Trp Ala 
                 645                650                655
Leu Leu Gly Leu Met Ala Val Arg His Pro Asp Ile Ser Ala Gln Glu 
             660                665                670
Arg Gly Ile Arg Cys Leu Leu Gly Lys Gln Phe Pro Asn Gly Glu Trp 
         675                680                685
Pro Gln Glu Asn Ile Ser Gly Val Phe Asn Lys Ser Cys Ala Ile Ser 
     690                695                700
Tyr Thr Asn Tyr Arg Asn Ile Phe Pro Ile Trp Ala Leu Gly Arg Phe 
 705                710                715                720
Ser Ser Leu Tyr Pro Asp Asn Thr Leu Ala Gly His Ile 
                 725                730



<210> 2055
<211> 3206
<212> DNA
<213> Homo sapiens
<308> NM_002340
<400> 2055

cccttgcct  ctgctcatg  gtgtggaga  tgatattct  gaagactga  aggcagatt  60
actattaac  aacacatag  ctgtggccc  gcaaagcca  cccaatccc  gcacaaggg  120
aaaaggcca  cattagagc  ctgcagcag  aatgacgga  ggcacgtgt  tgcggcgcc  180
agggggccc  tacaagacc  agcccgcca  cgacctcgg  cgctggcga  tcaactgcg  240
gaggggccg  cagacgtgg  cctacctgc  ggacgagcg  gccggccgc  agcagaccg  300
cctggaagc  tacgccctg  ggctggaca  caagaatta  tttaaggac  tgcccaaag  360
ccacaccgc  tttgagggg  ctctgaacg  gatgacatt  tacgtgggg  tgcaggctg  420
ggatgggca  tggacgggt  attatggtg  cccactttt  ctcctgcca  gcctcctga  480
cacttgcca  gtggcacgc  tccctctgc  agccggata  agagaagag  ttgtgcggt  540
cctgcggtc  gtgcagctc  ctgacggtg  ctggggcct  cacattgag  ataagtcca  600
cgtgtttgg  actgcgctc  actatgtgt  tctcagaat  ctgggtgtt  ggcctgacg  660
tcctgacct  gtacgagcc  ggaacattc  tcacaagaa  ggtggtgct  tggccatcc  720
ctcctgggg  aagttctgg  tggctgtcc  gaatgttta  agctgggaa  gcctcaata  780
cctgttccc  gagatgtgg  tgtttcctg  ctgggcacc  gcacacccc  ccacactct  840
gtgccactg  cggcaggtg  acctgccca  gagctactg  tacgccgtt  ggctgagtg  900
cgcggaaga  ccgctggtc  agagcctcc  ccaggagct  tatgtggag  acttcgcca  960
cattgactg  ctggcgcag  ggaacaacg  ggcccccga  gagctgtac  cgccccaca  1020
ctggctgct  cgcgtggta  atgcgctcc  caacctgta  gagcaccac  acagtgccc  1080
cctgcggca  cgggccgtg  agaagctgt  tgaacacat  gtggccgac  accgattca  1140
caagagcat  agcatcggc  cgatctcga  aaccatcaa  atgcttgtg  gctggtatg  1200
ggacgggcc  gcctccact  ccttccagg  gcatgtctc  agaatcccg  actatctct  1260
gatgggcct  gacggcatg  aaatgcagg  caccaacgg  tcacagatc  gggacaccg  1320
attcgccat  caggctctg  ttgaggcgg  cgggcacca  aggcccgag  tttcgtcct  1380
cctgcagaa  gctcatgag  tcctgaggc  ctcacaggt  ccagataac  ctcccgact  1440
ccagaagta  taccgccag  tgcgcaagg  tggcttctc  ttcagtacg  tggactgcg  1500
ctggatcgt  tctgactgc  cggctgagg  cttgaaggc  gtgctgctc  tgcaggaga  1560
gtgtcccca  gtcaccgag  acatcccca  agaacggct  tgcgatgct  tggctgtgc  1620
gctgaacat  agaaatcca  atggagggt  cgccaccta  gagaccaag  gtggggggc  1680
cttgctgga  ctgctgaac  cctcggagg  cttcgggga  atcatgatt  actacacct  1740
tgtggagtg  acctcagcc  tgatgcagg  gcttaagta  ttccacaag  gtttcccgg  1800
gcacagggc  gcggagatc  gggagaccc  cacgcaggg  ttagagttc  gtcggcggc  1860
gcagagggc  gatggctcc  gggaaggct  ctggggagt  tgcttcacc  acggcacct  1920
gtttggcct  gaggccttc  cctgtatgg  gcagaccta  cgagatggg  ctgcctgtg  1980
agaggtctc  cgggcctgt  acttcctgc  gtcccggca  atggcagac  gaggctggg  2040
ggaggactt  gagtcctgc  aggagcggc  ttatttgca  agtgcccag  cccagatcc  2100
taacacatg  tgggccatg  tggggctga  ggccgttcg  catcctgac  tcgaggccc  2160
ggagagagg  gtccggtgt  tacttgaga  acagctccc  aatggcgac  ggccgcagg  2220
aaacattgc  ggggtcttc  acaagtcct  tgccatctc  tacacgagc  acaggaaca  2280
cttccccat  tgggccctc  gccgcttct  ccagctgta  cctgagaga  cccttgctg  2340
ccacccctg  gaacatgcc  acctgctgg  tgccgtctg  gcgttccag  gaggccaag  2400
ggtcctggc  gggttgggg  gccctccca  aaccctgtc  tgggctcca  cccctcaac  2460
tctatctca  agatgtgaa  ctgggggcc  ggctggagg  agggatggg  acagggtgg  2520
tggcttaga  tcttgattt  tactgtagg  tcatttctg  aagtagctt  tcgggcttg  2580
gtgaggaag  gggcacagg  gccgtgacc  ctgaggagg  acagcgcct  ctgccacct  2640
tgggcacgg  ctcaaggta  tgaggctag  aggtttttt  tgaccaata  ctgagttct  2700
gggagagga  cagctgtgc  tgtgtgatt  cttagtgtc  agtgggctc  gggctgggg  2760
cggccctgg  caggcttct  ctgcacctt  tgtctgctg  gctgaggga  acgagggca  2820
ccctgtgac  atggcaggt  gtgtgcatc  gtgaatagc  cagtgcggg  gttgctcat  2880
gagcatcct  aggccgtgc  gcagggagc  ccatgcccc  gggtcgtga  cttgcctgc  2940
tatggggtg  tgtcatgga  cctcatgcc  ctgggtcgt  agctcgcct  agtatgggg  3000
ggtgtcatg  agccgcata  ccctgggtt  tgagctcgc  tgcatatgc  gggtctgtc  3060
tggaacatc  caagtctgt  cagcaggga  ccccatgcc  ctgggacat  aacccacct  3120
cgtggaatg  tgtttgtga  gtgtctaca  ggtttatag  agtcttgtg  acacagaaa  3180
gcacagggg  cacttacgg  cacaga  3206



<210> 2056
<211> 732
<212> PRT
<213> Homo sapiens
<308> P48449
<400> 2056

Met Thr Glu Gly Thr Cys Leu Arg Arg Arg Gly Gly Pro Tyr Lys Thr 
  1               5                  10                  15
Glu Pro Ala Thr Asp Leu Gly Arg Trp Arg Leu Asn Cys Glu Arg Gly 
             20                  25                  30
Arg Gln Thr Trp Thr Tyr Leu Gln Asp Glu Arg Ala Gly Arg Glu Gln 
         35                  40                  45
Thr Gly Leu Glu Ala Tyr Ala Leu Gly Leu Asp Thr Lys Asn Tyr Phe 
     50                  55                  60
Lys Asp Leu Pro Lys Ala His Thr Ala Phe Glu Gly Ala Leu Asn Gly 
 65                  70                  75                  80
Met Thr Phe Tyr Val Gly Leu Gln Ala Glu Asp Gly His Trp Thr Gly 
                 85                  90                  95
Asp Tyr Gly Gly Pro Leu Phe Leu Leu Pro Gly Leu Leu Ile Thr Cys 
             100                105                110
His Val Ala Arg Ile Pro Leu Pro Ala Gly Tyr Arg Glu Glu Ile Val 
         115                120                125
Arg Tyr Leu Arg Ser Val Gln Leu Pro Asp Gly Gly Trp Gly Leu His 
     130                135                140
Ile Glu Asp Lys Ser Thr Val Phe Gly Thr Ala Leu Asn Tyr Val Ser 
 145                150                155                160
Leu Arg Ile Leu Gly Val Gly Pro Asp Asp Pro Asp Leu Val Arg Ala 
                 165                170                175
Arg Asn Ile Leu His Lys Lys Gly Gly Ala Val Ala Ile Pro Ser Trp 
             180                185                190
Gly Lys Phe Trp Leu Ala Val Leu Asn Val Tyr Ser Trp Glu Gly Leu 
         195                200                205
Asn Thr Leu Phe Pro Glu Met Trp Leu Phe Pro Asp Trp Ala Pro Ala 
     210                215                220
His Pro Ser Thr Leu Trp Cys His Cys Arg Gln Val Tyr Leu Pro Met 
 225                230                235                240
Ser Tyr Cys Tyr Ala Val Arg Leu Ser Ala Ala Glu Asp Pro Leu Val 
                 245                250                255
Gln Ser Leu Arg Gln Glu Leu Tyr Val Glu Asp Phe Ala Ser Ile Asp 
             260                265                270
Trp Leu Ala Gln Arg Asn Asn Val Ala Pro Asp Glu Leu Tyr Thr Pro 
         275                280                285
His Ser Trp Leu Leu Arg Val Val Tyr Ala Leu Leu Asn Leu Tyr Glu 
     290                295                300
His His His Ser Ala His Leu Arg Gln Arg Ala Val Gln Lys Leu Tyr 
 305                310                315                320
Glu His Ile Val Ala Asp Asp Arg Phe Thr Lys Ser Ile Ser Ile Gly 
                 325                330                335
Pro Ile Ser Lys Thr Ile Asn Met Leu Val Arg Trp Tyr Val Asp Gly 
             340                345                350
Pro Ala Ser Thr Ala Phe Gln Glu His Val Ser Arg Ile Pro Asp Tyr 
         355                360                365
Leu Trp Met Gly Leu Asp Gly Met Lys Met Gln Gly Thr Asn Gly Ser 
     370                375                380
Gln Ile Trp Asp Thr Ala Phe Ala Ile Gln Ala Leu Leu Glu Ala Gly 
 385                390                395                400
Gly His His Arg Pro Glu Phe Ser Ser Cys Leu Gln Lys Ala His Glu 
                 405                410                415
Phe Leu Arg Leu Ser Gln Val Pro Asp Asn Pro Pro Asp Tyr Gln Lys 
             420                425                430
Tyr Tyr Arg Gln Met Arg Lys Gly Gly Phe Ser Phe Ser Thr Leu Asp 
         435                440                445
Cys Gly Trp Ile Val Ser Asp Cys Thr Ala Glu Ala Leu Lys Ala Val 
     450                455                460
Leu Leu Leu Gln Glu Lys Cys Pro His Val Thr Glu His Ile Pro Arg 
 465                470                475                480
Glu Arg Leu Cys Asp Ala Val Ala Val Leu Leu Asn Met Arg Asn Pro 
                 485                490                495
Asp Gly Gly Phe Ala Thr Tyr Glu Thr Lys Arg Gly Gly His Leu Leu 
             500                505                510
Glu Leu Leu Asn Pro Ser Glu Val Phe Gly Asp Ile Met Ile Asp Tyr 
         515                520                525
Thr Tyr Val Glu Cys Thr Ser Ala Val Met Gln Ala Leu Lys Tyr Phe 
     530                535                540
His Lys Arg Phe Pro Glu His Arg Ala Ala Glu Ile Arg Glu Thr Leu 
 545                550                555                560
Thr Gln Gly Leu Glu Phe Cys Arg Arg Gln Gln Arg Ala Asp Gly Ser 
                 565                570                575
Trp Glu Gly Ser Trp Gly Val Cys Phe Thr Tyr Gly Thr Trp Phe Gly 
             580                585                590
Leu Glu Ala Phe Ala Cys Met Gly Gln Thr Tyr Arg Asp Gly Thr Ala 
         595                600                605
Cys Ala Glu Val Ser Arg Ala Cys Asp Phe Leu Leu Ser Arg Gln Met 
     610                615                620
Ala Asp Gly Gly Trp Gly Glu Asp Phe Glu Ser Cys Glu Glu Arg Arg 
 625                630                635                640
Tyr Leu Gln Ser Ala Gln Ser Gln Ile His Asn Thr Cys Trp Ala Met 
                 645                650                655
Met Gly Leu Met Ala Val Arg His Pro Asp Ile Glu Ala Gln Glu Arg 
             660                665                670
Gly Val Arg Cys Leu Leu Glu Lys Gln Leu Pro Asn Gly Asp Trp Pro 
         675                680                685
Gln Glu Asn Ile Ala Gly Val Phe Asn Lys Ser Cys Ala Ile Ser Tyr 
     690                695                700
Thr Ser Tyr Arg Asn Ile Phe Pro Ile Trp Ala Leu Gly Arg Phe Ser 
 705                710                715                720
Gln Leu Tyr Pro Glu Arg Ala Leu Ala Gly His Pro 
                 725                730



<210> 2057
<211> 1640
<212> DNA
<213> Rattus norvegicus
<308> D45254
<400> 2057

agagccgtg  gcagcggcg  gtgtggggc  gtgtgcaga  ccgcgtgtg  cgcaggcaa  60
gaccctgaa  ataaacagc  gctgctttg  gagtctcct  cttgggtct  cgtccgagt  120
tcctctgct  tgggcagct  agacgccga  gctctaact  cagctatga  cagcaacga  180
tgcttcaag  gtggacgat  tggccactg  gccagggaa  gccctactg  tggaggtcg  240
ggtcgtgga  tgagaagcc  cggcagagg  ggttttacc  cggatagag  gttccagtt  300
gtttcctcg  ctcttcctg  catctgtta  cgctgtggt  agtctggtc  tcttgccaa  360
gattgtgat  ttcaggagg  tgcctgcta  aactgcggt  gaggtggcc  cattgccaa  420
gactgcaag  agcccaaga  agagcgaga  caatgctgc  acaactgtg  caagccagg  480
catctggct  gtgactgtg  ccacgcgga  gagcagaag  gctattcct  tggggaatt  540
ggacatatt  aaaaagact  caccaaggt  aagtgctat  ggtgtggtg  aactggtca  600
gtagccatc  attgcagca  gacaagtga  gtcaactgt  accgctgtg  cgagtcagg  660
catcttgca  gggaatgca  aattgaggc  actgcctaa  tattttcct  tgtcgcccc  720
cctttttct  attgatggt  gtattattt  ctctgaatc  tcttcactg  ccaaaggtt  780
gcagataga  gctgttccc  ggccagtga  ctttacttg  agtgtaaaa  gaggaaagg  840
gtggaaaaa  aaccgaatt  ctgcattta  ctacaaaaa  agtttatgt  tagtttggt  900
gaggtgtta  gtataatgc  ttgttaaag  acccccttt  cgtgccact  gtgaatagg  960
attaatgaa  gggaagagt  cagtcagac  agtaagccc  tctgggttt  agtgtgttc  1020
catgtagga  gtaaaacca  ttctggatg  atctaagct  ccatgaata  ctttaattc  1080
tagcataat  atggccttg  attgtctga  ctcagtagc  attaaataa  atcgagtaa  1140
atctgcatc  ggccctcat  gaacattca  ttgagttgg  agtaaactg  aaagacaaa  1200
gtgttgaag  atatgccag  gaatctggc  aaagcctaa  acaggagca  cttcatccc  1260
gtgttgatg  tggacgtac  gaaggtgat  gcaaaggtg  agaacacat  ttttcaaag  1320
ctaaatcta  aacccagag  aaacatccg  tgctcagag  tagcataat  tggagctat  1380
caggaattg  agagaaatg  attttcaca  aaatcaaga  gttattttt  tatactata  1440
cacttagac  actgtgttt  atttgctgt  atcagtttt  aaagtcaga  ggaaaaagc  1500
actgaagtc  tagaaaata  aaaatgtaa  tttaaacta  tccaataaa  ctggaggag  1560
aaggggagt  ttgactaaa  ttccttttg  ttgttttaa  ttttcatca  tgtatatag  1620
acaaaatgc  atattaaaga  1640



<210> 2058
<211> 177
<212> PRT
<213> Rattus norvegicus
<308> P20694
<400> 2058

Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
  1               5                  10                  15
Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
             20                  25                  30
Gly Arg Gly Gly Phe Thr Ser Asp Arg Gly Phe Gln Phe Val Ser Ser 
         35                  40                  45
Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala 
     50                  55                  60
Lys Asp Cys Asp Leu Gln Glu Asp Ala Cys Tyr Asn Cys Gly Arg Gly 
 65                  70                  75                  80
Gly His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg Glu Gln 
                 85                  90                  95
Cys Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp Cys Asp 
             100                105                110
His Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Phe Gly His Ile 
         115                120                125
Gln Lys Asp Cys Thr Lys Val Lys Cys Tyr Arg Cys Gly Glu Thr Gly 
     130                135                140
His Val Ala Ile Asn Cys Ser Lys Thr Ser Glu Val Asn Cys Tyr Arg 
 145                150                155                160
Cys Gly Glu Ser Gly His Leu Ala Arg Glu Cys Thr Ile Glu Ala Thr 
                 165                170                175
Ala 
             180



<210> 2060
<211> 177
<212> PRT
<213> Homo sapiens
<308> P20694
<400> 2060

Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
  1               5                  10                  15
Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
             20                  25                  30
Gly Arg Gly Gly Phe Thr Ser Asp Arg Gly Phe Gln Phe Val Ser Ser 
         35                  40                  45
Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala 
     50                  55                  60
Lys Asp Cys Asp Leu Gln Glu Asp Ala Cys Tyr Asn Cys Gly Arg Gly 
 65                  70                  75                  80
Gly His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg Glu Gln 
                 85                  90                  95
Cys Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp Cys Asp 
             100                105                110
His Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Phe Gly His Ile 
         115                120                125
Gln Lys Asp Cys Thr Lys Val Lys Cys Tyr Arg Cys Gly Glu Thr Gly 
     130                135                140
His Val Ala Ile Asn Cys Ser Lys Thr Ser Glu Val Asn Cys Tyr Arg 
 145                150                155                160
Cys Gly Glu Ser Gly His Leu Ala Arg Glu Cys Thr Ile Glu Ala Thr 
                 165                170                175
Ala 
             180



<210> 2061
<211> 1640
<212> DNA
<213> Rattus norvegicus
<308> D45254
<400> 2061

agagccgtg  gcagcggcg  gtgtggggc  gtgtgcaga  ccgcgtgtg  cgcaggcaa  60
gaccctgaa  ataaacagc  gctgctttg  gagtctcct  cttgggtct  cgtccgagt  120
tcctctgct  tgggcagct  agacgccga  gctctaact  cagctatga  cagcaacga  180
tgcttcaag  gtggacgat  tggccactg  gccagggaa  gccctactg  tggaggtcg  240
ggtcgtgga  tgagaagcc  cggcagagg  ggttttacc  cggatagag  gttccagtt  300
gtttcctcg  ctcttcctg  catctgtta  cgctgtggt  agtctggtc  tcttgccaa  360
gattgtgat  ttcaggagg  tgcctgcta  aactgcggt  gaggtggcc  cattgccaa  420
gactgcaag  agcccaaga  agagcgaga  caatgctgc  acaactgtg  caagccagg  480
catctggct  gtgactgtg  ccacgcgga  gagcagaag  gctattcct  tggggaatt  540
ggacatatt  aaaaagact  caccaaggt  aagtgctat  ggtgtggtg  aactggtca  600
gtagccatc  attgcagca  gacaagtga  gtcaactgt  accgctgtg  cgagtcagg  660
catcttgca  gggaatgca  aattgaggc  actgcctaa  tattttcct  tgtcgcccc  720
cctttttct  attgatggt  gtattattt  ctctgaatc  tcttcactg  ccaaaggtt  780
gcagataga  gctgttccc  ggccagtga  ctttacttg  agtgtaaaa  gaggaaagg  840
gtggaaaaa  aaccgaatt  ctgcattta  ctacaaaaa  agtttatgt  tagtttggt  900
gaggtgtta  gtataatgc  ttgttaaag  acccccttt  cgtgccact  gtgaatagg  960
attaatgaa  gggaagagt  cagtcagac  agtaagccc  tctgggttt  agtgtgttc  1020
catgtagga  gtaaaacca  ttctggatg  atctaagct  ccatgaata  ctttaattc  1080
tagcataat  atggccttg  attgtctga  ctcagtagc  attaaataa  atcgagtaa  1140
atctgcatc  ggccctcat  gaacattca  ttgagttgg  agtaaactg  aaagacaaa  1200
gtgttgaag  atatgccag  gaatctggc  aaagcctaa  acaggagca  cttcatccc  1260
gtgttgatg  tggacgtac  gaaggtgat  gcaaaggtg  agaacacat  ttttcaaag  1320
ctaaatcta  aacccagag  aaacatccg  tgctcagag  tagcataat  tggagctat  1380
caggaattg  agagaaatg  attttcaca  aaatcaaga  gttattttt  tatactata  1440
cacttagac  actgtgttt  atttgctgt  atcagtttt  aaagtcaga  ggaaaaagc  1500
actgaagtc  tagaaaata  aaaatgtaa  tttaaacta  tccaataaa  ctggaggag  1560
aaggggagt  ttgactaaa  ttccttttg  ttgttttaa  ttttcatca  tgtatatag  1620
acaaaatgc  atattaaaga  1640



<210> 2062
<211> 177
<212> PRT
<213> Rattus norvegicus
<308> P20694
<400> 2062

Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
  1               5                  10                  15
Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
             20                  25                  30
Gly Arg Gly Gly Phe Thr Ser Asp Arg Gly Phe Gln Phe Val Ser Ser 
         35                  40                  45
Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala 
     50                  55                  60
Lys Asp Cys Asp Leu Gln Glu Asp Ala Cys Tyr Asn Cys Gly Arg Gly 
 65                  70                  75                  80
Gly His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg Glu Gln 
                 85                  90                  95
Cys Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp Cys Asp 
             100                105                110
His Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Phe Gly His Ile 
         115                120                125
Gln Lys Asp Cys Thr Lys Val Lys Cys Tyr Arg Cys Gly Glu Thr Gly 
     130                135                140
His Val Ala Ile Asn Cys Ser Lys Thr Ser Glu Val Asn Cys Tyr Arg 
 145                150                155                160
Cys Gly Glu Ser Gly His Leu Ala Arg Glu Cys Thr Ile Glu Ala Thr 
                 165                170                175
Ala 
             180



<210> 2064
<211> 177
<212> PRT
<213> Homo sapiens
<308> P20694
<400> 2064

Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
  1               5                  10                  15
Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
             20                  25                  30
Gly Arg Gly Gly Phe Thr Ser Asp Arg Gly Phe Gln Phe Val Ser Ser 
         35                  40                  45
Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala 
     50                  55                  60
Lys Asp Cys Asp Leu Gln Glu Asp Ala Cys Tyr Asn Cys Gly Arg Gly 
 65                  70                  75                  80
Gly His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg Glu Gln 
                 85                  90                  95
Cys Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp Cys Asp 
             100                105                110
His Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Phe Gly His Ile 
         115                120                125
Gln Lys Asp Cys Thr Lys Val Lys Cys Tyr Arg Cys Gly Glu Thr Gly 
     130                135                140
His Val Ala Ile Asn Cys Ser Lys Thr Ser Glu Val Asn Cys Tyr Arg 
 145                150                155                160
Cys Gly Glu Ser Gly His Leu Ala Arg Glu Cys Thr Ile Glu Ala Thr 
                 165                170                175
Ala 
             180



<210> 2065
<211> 1223
<212> DNA
<213> Rattus norvegicus
<308> D45255
<400> 2065

ccggcgttg  gctgaggct  ccaccactg  ccctgggac  ccgaggctg  gatgagccc  60
tgcgggcgg  ccctacata  atccagagg  gccatggcc  tgctggcgc  gaaattccc  120
cgtacccgg  tacccgtgg  agccagtgc  ctctgtgtg  tggtcctct  ttggctcta  180
gtcttccct  tctaccggc  gcccaacga  aaggagatc  tgcaaggag  gctggcgca  240
cgcacagct  ggaggagga  ccagacgtc  gccaggctc  tcaggagac  aatggaaga  300
tgctgcaac  ccgcccatc  ctttgcaat  acgaaggtg  actccccca  ggggaagag  360
ctgtggtat  acggggagt  tctatactc  ctcaccatc  acaactcca  gtactccct  420
ttcccccag  caaccccct  ccagctgcc  ttgaagaaa  gtgcggtgg  gggaaacgg  480
gggattctg  agatgagtg  ctgtggccg  caaatagat  aagcaaatt  tgtcatgcg  540
tgtaacctt  ctcccttgt  aagtgaata  accagagat  tgggttcca  gactcagtt  600
gtgacagct  accccagca  aattcgcca  agatttgaa  acctgctgt  gtccagaaa  660
aagtttgtg  acaacatga  gatctataa  cacagttac  tatacatgc  tgccttttc  720
atgaagacg  gaacagagc  gtctctccg  gtgtactac  ccctgaaag  cgctggagc  780
aatcaaaca  tgctttttg  taaccccaa  tttcttcga  acattggaa  gttctggaa  840
ggtaggggg  tccatgcca  gcgcctgtc  acaggactc  ttttggtga  tgcagcctt  900
ggcctttgt  aggaggtgt  catctacgg  ttctggccc  tctccgtga  catgcaagg  960
gaacctatc  gccaccatt  ctatgacaa  gtcttgccc  tctcaggct  ccatgccat  1020
cctgaggag  ttcttcaac  ctggtatct  cataaaatg  gtgcactga  gatgcaact  1080
gacccatgt  aggagccgt  gccgccaca  cccacttcc  agggactgc  gaagaggaa  1140
agactggat  ggggtattt  tttgctaga  tttttttta  gtgactttc  aaaggagct  1200
ccaaagtgt  tcatggatt  gcg  1223



<210> 2066
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> BAA08213
<400> 2066

Met Ser Pro Gly Gly Gly Pro Leu His Thr Ser Arg Gly Ala Met Ala 
  1               5                  10                  15
Met Leu Gly Gly Lys Phe Pro Arg Thr Arg Leu Pro Val Gly Ala Ser 
             20                  25                  30
Ala Leu Cys Val Val Val Leu Cys Trp Leu Tyr Val Phe Pro Val Tyr 
         35                  40                  45
Arg Leu Pro Asn Glu Lys Glu Ile Val Gln Gly Val Leu Ala Gln Arg 
     50                  55                  60
Thr Ala Trp Arg Arg Asn Gln Thr Ser Ala Arg Leu Phe Arg Lys Gln 
 65                  70                  75                  80
Met Glu Asp Cys Cys Asn Pro Ala His Leu Phe Ala Met Thr Lys Val 
                 85                  90                  95
Asn Ser Pro Met Gly Lys Ser Leu Trp Tyr Asp Gly Glu Phe Leu Tyr 
             100                105                110
Ser Leu Thr Ile Asp Thr Ser Thr Tyr Ser Leu Phe Pro Gln Ala Thr 
         115                120                125
Pro Phe Gln Leu Pro Leu Lys Lys Cys Ala Val Val Gly Asn Gly Gly 
     130                135                140
Ile Leu Lys Met Ser Gly Cys Gly Arg Gln Ile Asp Glu Ala Asn Phe 
 145                150                155                160
Val Met Arg Cys Asn Leu Pro Pro Leu Ser Ser Glu Tyr Thr Arg Asp 
                 165                170                175
Val Gly Ser Lys Thr Gln Leu Val Thr Ala Asn Pro Ser Ile Ile Arg 
             180                185                190
Gln Arg Phe Glu Asn Leu Leu Trp Ser Arg Lys Lys Phe Val Asp Asn 
         195                200                205
Met Lys Ile Tyr Asn His Ser Tyr Ile Tyr Met Pro Ala Phe Ser Met 
     210                215                220
Lys Thr Gly Thr Glu Pro Ser Leu Arg Val Tyr Tyr Thr Leu Lys Asp 
 225                230                235                240
Ala Gly Ala Asn Gln Thr Val Leu Phe Ala Asn Pro Asn Phe Leu Arg 
                 245                250                255
Asn Ile Gly Lys Phe Trp Lys Gly Arg Gly Ile His Ala Lys Arg Leu 
             260                265                270
Ser Thr Gly Leu Phe Leu Val Ser Ala Ala Leu Gly Leu Cys Glu Glu 
         275                280                285
Val Ser Ile Tyr Gly Phe Trp Pro Phe Ser Val Asn Met Gln Gly Glu 
     290                295                300
Pro Ile Ser His His Tyr Tyr Asp Asn Val Leu Pro Phe Ser Gly Phe 
 305                310                315                320
His Ala Met Pro Glu Glu Phe Leu Gln Leu Trp Tyr Leu His Lys Met 
                 325                330                335
Gly Ala Leu Arg Met Gln Leu Asp Pro Cys Glu Asn Pro Pro Pro Ser 
             340                345                350
Arg His His Ser Pro Pro Ser 
         355



<210> 2067
<211> 5233
<212> DNA
<213> Rattus norvegicus
<308> D45920
<400> 2067

aggcagccg  cgccgcact  cctgaggcc  ccgctccgc  tcggcgggc  ggtggctgg  60
ggccggtcc  cagtcgccg  tcgggccgc  cgcgtccag  cttcggagg  ttcggaggc  120
ccgggctcc  gcgcccgct  tcttttgtc  gcgcagagc  ggcgctcgc  tcccctcgc  180
ggtacctcc  gctgctttt  gcctgcttc  ccctcccgc  cacatcttc  ccccgcccc  240
gccgccggt  cgcgccggc  gctgacctc  tggaccaca  cccgaggac  cctctgccc  300
agtgatgtc  cctctctac  aagttgcgg  cgccgctgc  gccgccgtc  cgcgctgaa  360
caaagtcta  cggcgtttc  ttctggtgc  tgagcgcac  cttactcag  gctggacgc  420
gctggcggt  gtgctgtct  gccgggagc  tagaacgtg  ttggccatg  ctgagggcg  480
ggctagcag  gaggctccg  cgcctctcg  cgttgcggg  ggcgaagac  accctcgag  540
cggcgccga  gctgcctcc  gggacgctg  acccgaggc  tcggggggc  ggatgaggg  600
ccgtcgcag  ggggttgcg  tgccgggca  tgcgggggt  cccgcggat  gcgaggctg  660
cctcctgga  gcggcacga  cgacccccc  gcgcacgag  atcatcaag  atccttcaa  720
ccaaaaatg  ggtggcaga  agaaaacag  gtctttcag  agcatgcca  cggagaaga  780
gattagcag  gcccatgac  gcattagct  catgcaggc  ggctgcgag  tgaagaaag  840
gcgaccgaa  tctcgcatc  acaaccgat  tttcaccct  gacactgac  tccaggctc  900
acgctggga  ccttccaag  aagacctcg  aaaagccaa  ctggacatt  ctgccatca  960
agagatcag  ctggggaag  acacggaga  attcagaaa  aatggcctt  ctgaccaga  1020
ctgtgaaga  tgtgccttc  ccatactcc  tggggaaaa  tacgagtct  tggacctag  1080
tgccaattc  gcagatgta  caaacatct  ggtgtcggg  ttacggtac  tggtctctc  1140
cagtaagca  ccacttgac  ttatggagg  caaccagaa  acaccacgg  tcatgtggc  1200
gaaaacggt  tttgaagca  cagatgttg  tgggaatgg  attatgtta  aagatacct  1260
ggtggagtt  ataaaacaa  tcaacccta  tctgaagga  tctaagatc  ggttaaagt  1320
taaagaaat  cagaagagc  aagaaaaac  aactacccg  gtaacagaa  aggaattct  1380
tgaagcgtt  tgtgaactt  gcactagac  agaagtgta  ttcttactt  ttcagatat  1440
taagaacaa  gagtatctg  atgctaatg  cctcatgct  tttttagaa  ttgagcaag  1500
ggtcaccca  gtcactgag  atatgtgct  agacatcat  aggagatac  aactttctg  1560
agatggccg  cagaaaggc  tccttgcaa  tgatggctt  acccagtat  tattatctc  1620
agaatgcga  atttttgat  cagagcaaa  gaaggttgc  caagacatg  cccaaccct  1680
atctcacta  tatatcaat  cgtcccata  tacctacct  atagaagat  agttcaggg  1740
gccagctga  atcaatggg  atgtgaggg  tttgaagat  ggctgtcga  gcattgagc  1800
tgatgtaag  gacggtcca  ataatgaac  catcctgtg  aataggaac  acatggcca  1860
gctcctttc  tttcgaagt  ttctggagg  gataaataa  ttcgccttc  tcgcttcag  1920
gtacccact  attctctgc  tggggaatc  ctgttccct  ccacagcag  gggtcatgg  1980
tcagcagat  aaaaaggtg  ttggcaata  actttatac  gaagcacct  tgtcttcag  2040
atcctacct  ccgtcgcct  aaaaactaa  acatatgat  attgtgaaa  gaaagaaat  2100
gccttcgga  tcagatctg  tagagggag  agtgaccga  gaggatgaa  aagctgaga  2160
gtcccggag  gtgtcggga  attacaacg  tgagcagaa  catatctgg  tctgccgag  2220
gctctctga  ttggtatcc  tctgtaaat  cgttcagta  agggatttt  aactgtcta  2280
gaaaaccca  aactactgg  aaatttgtt  atttagtga  acattggcc  gccggatcg  2340
aaatgagta  ccagaggat  tcgtgaatt  taacaagaa  ttcttatca  gggtctacc  2400
tagtgccat  aggatagat  ccagtaatt  gaacccaca  gacttctgg  attgtggct  2460
tcagattgt  gcaatgaat  ttcaaactc  tggtccaat  atggacctc  acaccggct  2520
gtttcttca  aatgggggc  gtggctacg  cctcaggcc  tctatcatg  gagatgaag  2580
ttcgtactt  agtgcaaac  caaagggca  tgtccctgg  gtgtctccc  tgcttcttc  2640
catcaagat  atcagtggt  agaacttcc  aaagcccaa  ggagcttgt  ccaaagggg  2700
tgtcataga  ccctacgtt  gtgtagaga  tcatggaat  ccagctgat  gctccgagc  2760
aagaactaa  actgtacaa  agaacagcg  taatcccat  ttcgatgaa  ctttcgagt  2820
tcaagtcaa  cttcccgag  tgaccatgg  ccgttttgt  attttggat  atgattaca  2880
tggagatga  ttcattggg  aatacacga  accgtttga  tgtctgcaa  ctgggtacc  2940
gcatgtccc  ttgcgctcc  ttgtggggg  tatcatgga  catgtgacc  tttttgtcc  3000
catagcaat  accaatcgg  gtggcggag  aaaagcgca  aagcgaagt  tttccgtga  3060
aatggggaa  aaagttcga  aatacacca  gctcagaaa  atcggtctt  aaaccatag  3120
tgatatctt  aaaatagca  ttcatcctt  gcgagaagc  atagatatg  gagaaaaca  3180
gcagaacgc  atagtgtct  ttaaggagc  gtgtggact  ccaccgatt  ccagtctga  3240
acagtgcct  ttaaccctg  cctctcgtc  catcaccag  gatagtact  cctccgtgt  3300
tctggtgat  aaggactgc  ttccttacc  ggagcctct  ggcacaatt  cagatgtgc  3360
gaagaggat  ctggctgca  atgatctga  gattcaaga  agtcgggtc  tcatagaaa  3420
ggctgacac  gtccaggaa  aaattgtac  gtgtcagaa  gcagggatg  aattccatg  3480
agaacttca  aatctaggg  caaaggaag  cttgaaggg  agaaaactc  acaaggcca  3540
cgagagctt  gcttggaat  ttactgtat  gaagggaca  ggagacctg  tgaagaatg  3600
caagaatga  gccgtagag  acataaagc  gatccagct  gcctgtttg  cttgtggac  3660
gagtaaagg  cctggcagc  ctgcagagg  caagggcaa  cgcagcttg  aagccatag  3720
ggagaagga  agcagtgaa  agaacggga  gttgtgagc  gggcagtgc  caggccctt  3780
tccaacact  tggtttctc  ttcttctcg  tttgttttg  ttttacatt  ttcagatgt  3840
cacagaaat  atgcccttt  cggggtgtt  tacataaac  tatattttc  cagtgtcag  3900
attttactg  agttaattt  tctaagtta  aacttttag  agcagtgtt  taaactttg  3960
gctgtgagt  tatacttac  tgtggctgc  tgtgtgtgt  tgtgtgtgt  tgtttgtgt  4020
tgtgtgtgt  tgtgtgtgt  tgtgtgtga  agagagaga  agagagaga  agagagaga  4080
agagagaga  agtaagagt  cctgttaaa  tattctctg  cgcattgtt  gttttaata  4140
gttattctt  tatctttaa  atcatttgg  gatagttga  aatctgaat  ctaatgagc  4200
tttattata  ccccttgct  tcgttagtt  tacctctct  cctttgtca  ataatttgg  4260
gatctcagc  cagcttatg  ttgaagaaa  ccaaattta  aagagcaaa  gcgttttat  4320
gattacata  agatttaaa  gttcctaaa  attacatta  aaatgaaag  gaatagaaa  4380
atcttttaa  atcataatt  tggaaagat  aacaaattc  tttcttcat  agcaaaatc  4440
ttgagatat  tattaacta  aatcacatt  aggaagttt  tgtagctgt  tactgagca  4500
gtggtttcg  tagaagagc  gagtgcaga  aacctgtag  cactgggca  tactttgaa  4560
cccactaaa  gctctactg  actagcact  ttgatgtga  cataacact  agttgtgca  4620
tttcaaggt  tgcagaaag  cctcattct  ctgggccgg  agtatggaa  tcattttct  4680
ttaccagtg  tgggcagat  caagtgctt  gccaggact  gatctagta  agattacta  4740
atttaagtg  caacacctt  ttaaaataa  atattatca  gttgagctg  cataaattc  4800
gtaagtccg  taacatctt  ctgatgatt  gagaactaa  taattagac  acatgtatg  4860
tataatttt  aaacataca  taaaaacca  gagcaagtg  ctaattagg  tacatttat  4920
attatatct  gataatctt  ccctaatgt  ttcataaac  tcttaaatg  catgttcat  4980
cattaccac  aacagaact  aatgttcta  gattatgaa  gaatatatt  gtttaaaac  5040
ttgctttta  tttgaaaag  ttcttaatt  atttgatta  caaatatat  aatttgggg  5100
agcctagag  agataatca  tgaaatttt  caaatataa  catcctcta  agctactat  5160
ttatttctg  ctgttctta  tactactct  ttcttgtcg  acattacca  aagagtaaa  5220
atactgaaa  cag  5233



<210> 2068
<211> 1096
<212> PRT
<213> Rattus norvegicus
<308> BAA08351
<400> 2068

Met Ala Glu Gly Ala Ala Ser Arg Glu Ala Pro Ala Pro Leu Asp Val 
  1               5                  10                  15
Ala Gly Gly Glu Asp Asp Pro Arg Ala Gly Ala Asp Ala Ala Ser Gly 
             20                  25                  30
Asp Ala Ala Pro Glu Ala Ser Gly Gly Arg Met Arg Asp Arg Arg Ser 
         35                  40                  45
Gly Val Ala Leu Pro Gly Asn Ala Gly Val Pro Ala Asp Ser Glu Ala 
     50                  55                  60
Gly Leu Leu Glu Ala Ala Arg Ala Thr Pro Arg Arg Thr Ser Ile Ile 
 65                  70                  75                  80
Lys Asp Pro Ser Asn Gln Lys Cys Gly Gly Arg Lys Lys Thr Val Ser 
                 85                  90                  95
Phe Ser Ser Met Pro Ser Glu Lys Lys Ile Ser Ser Ala His Asp Cys 
             100                105                110
Ile Ser Phe Met Gln Ala Gly Cys Glu Leu Lys Lys Val Arg Pro Asn 
         115                120                125
Ser Arg Ile Tyr Asn Arg Phe Phe Thr Leu Asp Thr Asp Leu Gln Ala 
     130                135                140
Leu Arg Trp Glu Pro Ser Lys Lys Asp Leu Glu Lys Ala Lys Leu Asp 
 145                150                155                160
Ile Ser Ala Ile Lys Glu Ile Arg Leu Gly Lys Asn Thr Glu Thr Phe 
                 165                170                175
Arg Asn Asn Gly Leu Ala Asp Gln Ile Cys Glu Asp Cys Ala Phe Ser 
             180                185                190
Ile Leu His Gly Glu Asn Tyr Glu Ser Leu Asp Leu Val Ala Asn Ser 
         195                200                205
Ala Asp Val Ala Asn Ile Trp Val Ser Gly Leu Arg Tyr Leu Val Ser 
     210                215                220
Arg Ser Lys Gln Pro Leu Asp Phe Met Glu Gly Asn Gln Asn Thr Pro 
 225                230                235                240
Arg Phe Met Trp Leu Lys Thr Val Phe Glu Ala Ala Asp Val Asp Gly 
                 245                250                255
Asn Gly Ile Met Leu Glu Asp Thr Ser Val Glu Leu Ile Lys Gln Leu 
             260                265                270
Asn Pro Thr Leu Lys Glu Ser Lys Ile Arg Leu Lys Phe Lys Glu Ile 
         275                280                285
Gln Lys Ser Lys Glu Lys Leu Thr Thr Arg Val Thr Glu Glu Glu Phe 
     290                295                300
Cys Glu Ala Phe Cys Glu Leu Cys Thr Arg Pro Glu Val Tyr Phe Leu 
 305                310                315                320
Leu Val Gln Ile Ser Lys Asn Lys Glu Tyr Leu Asp Ala Asn Asp Leu 
                 325                330                335
Met Leu Phe Leu Glu Val Glu Gln Gly Val Thr His Val Thr Glu Asp 
             340                345                350
Met Cys Leu Asp Ile Ile Arg Arg Tyr Glu Leu Ser Glu Asp Gly Arg 
         355                360                365
Gln Lys Gly Phe Leu Ala Ile Asp Gly Phe Thr Gln Tyr Leu Leu Ser 
     370                375                380
Pro Glu Cys Asp Ile Phe Asp Pro Glu Gln Lys Lys Val Ala Gln Asp 
 385                390                395                400
Met Thr Gln Pro Leu Ser His Tyr Tyr Ile Asn Ala Ser His Asn Thr 
                 405                410                415
Tyr Leu Ile Glu Asp Gln Phe Arg Gly Pro Ala Asp Ile Asn Gly Tyr 
             420                425                430
Val Arg Ala Leu Lys Met Gly Cys Arg Ser Ile Glu Leu Asp Val Ser 
         435                440                445
Asp Gly Pro Asp Asn Glu Pro Ile Leu Cys Asn Arg Asn Asn Met Ala 
     450                455                460
Met Leu Leu Ser Phe Arg Ser Val Leu Glu Val Ile Asn Lys Phe Ala 
 465                470                475                480
Phe Val Ala Ser Glu Tyr Pro Leu Ile Leu Cys Leu Gly Asn His Cys 
                 485                490                495
Ser Leu Pro Gln Gln Arg Val Met Val Gln Gln Met Lys Lys Val Phe 
             500                505                510
Gly Asn Lys Leu Tyr Thr Glu Ala Pro Leu Ser Ser Glu Ser Tyr Leu 
         515                520                525
Pro Ser Pro Glu Lys Leu Lys His Met Ile Ile Val Lys Gly Lys Lys 
     530                535                540
Leu Pro Ser Glu Ser Asp Leu Leu Glu Gly Glu Val Thr Asp Glu Asp 
 545                550                555                560
Glu Glu Ala Glu Met Ser Arg Arg Val Ser Gly Asp Tyr Asn Gly Glu 
                 565                570                575
Gln Lys His Ile Trp Leu Cys Arg Glu Leu Ser Asp Leu Val Ser Ile 
             580                585                590
Cys Lys Ser Val Gln Tyr Arg Asp Phe Glu Leu Ser Met Lys Thr Gln 
         595                600                605
Asn Tyr Trp Glu Ile Cys Ser Phe Ser Glu Thr Leu Ala Ser Arg Ile 
     610                615                620
Ala Asn Glu Tyr Pro Glu Asp Phe Val Asn Tyr Asn Lys Lys Phe Leu 
 625                630                635                640
Ser Arg Val Tyr Pro Ser Ala Met Arg Ile Asp Ser Ser Asn Leu Asn 
                 645                650                655
Pro Gln Asp Phe Trp Asn Cys Gly Cys Gln Ile Val Ala Met Asn Phe 
             660                665                670
Gln Thr Pro Gly Pro Met Met Asp Leu His Thr Gly Trp Phe Leu Gln 
         675                680                685
Asn Gly Gly Cys Gly Tyr Val Leu Arg Pro Ser Ile Met Arg Asp Glu 
     690                695                700
Val Ser Tyr Phe Ser Ala Asn Thr Lys Gly Ile Val Pro Gly Val Ser 
 705                710                715                720
Pro Leu Leu Leu His Ile Lys Ile Ile Ser Gly Gln Asn Phe Pro Lys 
                 725                730                735
Pro Lys Gly Ala Cys Ala Lys Gly Asp Val Ile Asp Pro Tyr Val Cys 
             740                745                750
Val Glu Ile His Gly Ile Pro Ala Asp Cys Ser Glu Gln Arg Thr Lys 
         755                760                765
Thr Val Gln Gln Asn Ser Asp Asn Pro Ile Phe Asp Glu Thr Phe Glu 
     770                775                780
Phe Gln Val Asn Leu Pro Glu Leu Thr Met Val Arg Phe Val Ile Leu 
 785                790                795                800
Asp Asp Asp Tyr Ile Gly Asp Glu Phe Ile Gly Gln Tyr Thr Ile Pro 
                 805                810                815
Phe Glu Cys Leu Gln Pro Gly Tyr Arg His Val Pro Leu Arg Ser Phe 
             820                825                830
Val Gly Asp Ile Met Glu His Val Thr Leu Phe Val His Ile Ala Ile 
         835                840                845
Thr Asn Arg Ser Gly Gly Gly Lys Ala Gln Lys Arg Ser Leu Ser Val 
     850                855                860
Arg Met Gly Lys Lys Val Arg Glu Tyr Thr Met Leu Arg Asn Ile Gly 
 865                870                875                880
Leu Lys Thr Ile Asp Asp Ile Phe Lys Ile Ala Val His Pro Leu Arg 
                 885                890                895
Glu Ala Ile Asp Met Arg Glu Asn Met Gln Asn Ala Ile Val Ser Val 
             900                905                910
Lys Glu Leu Cys Gly Leu Pro Pro Ile Ala Ser Leu Lys Gln Cys Leu 
         915                920                925
Leu Thr Leu Ser Ser Arg Leu Ile Thr Ser Asp Ser Thr Pro Ser Val 
     930                935                940
Ser Leu Val Met Lys Asp Cys Phe Pro Tyr Leu Glu Pro Leu Gly Thr 
 945                950                955                960
Ile Pro Asp Val Gln Lys Arg Met Leu Ala Ala Tyr Asp Leu Met Ile 
                 965                970                975
Gln Glu Ser Arg Val Leu Ile Glu Met Ala Asp Thr Val Gln Glu Lys 
             980                985                990
Ile Val Gln Cys Gln Lys Ala Gly Met Glu Phe His Glu Glu Leu His 
         995                1000                1005
Asn Leu Gly Ala Lys Glu Gly Leu Lys Gly Arg Lys Leu Asn Lys Ala 
     1010                1015                1020
Ile Glu Ser Phe Ala Trp Asn Ile Thr Val Leu Lys Gly Gln Gly Asp 
 1025                1030                1035                1040
Leu Leu Lys Asn Ala Lys Asn Glu Ala Val Glu Asn Ile Lys Gln Ile 
                 1045                1050                1055
Gln Leu Ala Cys Leu Ser Cys Gly Leu Ser Lys Gly Pro Gly Ser Ala 
             1060                1065                1070
Ala Glu Ala Lys Gly Lys Arg Ser Leu Glu Ala Ile Glu Glu Lys Glu 
         1075                1080                1085
Ser Ser Glu Glu Asn Gly Lys Leu 
     1090                1095



<210> 2069
<211> 4565
<212> DNA
<213> Homo sapiens
<308> D42108
<400> 2069

gaattccgg  cagcatcat  aaggcacat  gattctctc  ttgaacaat  cagctgctg  60
aggggatgg  gaagggatg  cactggcaa  tcaagactg  ctttcctac  tcttcagtg  120
ctctttcac  aatatgaag  taaaaccag  atccttcaa  ccaaaaatg  ggtggaaga  180
agaaaaccg  gtctttcag  agcatgcca  cggaaaaga  aattagcag  gcaaatgac  240
gcatcagct  catgcaagc  ggctgtgag  tgaagaaag  ccggccaaa  tctcgcatt  300
acaaccgtt  tttcactct  gacacagac  ttcaagctc  tcgctggga  ccttcaaag  360
aagacctcg  gaaagccaa  cttgatatt  ctgccataa  agagatcag  ctggggaaa  420
acacggaaa  atttacaaa  aatggcctt  ctgaccaga  ctgtgagga  tgtgccttt  480
ccatactcc  cggggaaaa  tatgagtct  tggacctag  tgccaattc  gcagatgtg  540
caaacatct  ggtgtctgg  ttacggtac  tggtttctc  aagtaagca  cctcttgat  600
ttatggagg  caaccagaa  acaccacgg  tcatgtggt  gaaaacagt  tttgaagca  660
cagatgttg  tgggaatgg  attatgttg  aagacacct  tgtagagtt  ataaaacaa  720
tcaacccta  tctgaagga  gccaagatc  ggttaaagt  taaagaaat  cagaagagc  780
aggaaaaac  aaccacccg  gtgaccgaa  aggaatttt  tgaagcttt  tgtgaactt  840
gcaccaggc  agaagtgta  ttcttactt  tacagatat  taaaaacaa  gaatatttg  900
atgccaatg  tctcatgct  tttttagaa  ctgagcaag  agtcaccca  atcaccgag  960
atatatgct  agacatcat  aggagatac  aactttctg  agagggacg  caaaaaggg  1020
ttcttgcaa  tgatggctt  acccagtat  tattgtcat  agaatgtga  atttttgat  1080
ctgagcaaa  gaaggttgc  caagatatg  cccagccat  atctcacta  tatatcaat  1140
cctctcata  cacctatct  atagaagac  agttcaggg  gccagctga  atcaatggg  1200
acattagag  tttgaaaat  ggctgtcga  gcgttgaac  cgatgtaag  gatggttca  1260
ataatgaac  aatcctttg  aatcgaaat  acatgacaa  ccatgtttc  tttcgaagt  1320
tcatagagg  aataaataa  tttgccttt  ttgcttctg  atacccact  attctttgc  1380
tgggaaatc  ctgctcctt  ccgcagcag  aggtaatgg  tcaacagat  aaaaaggtc  1440
ttggcaata  actctatac  gaagcacct  tgccctcag  atcctacct  ccatcacca  1500
aaaaattaa  aagaatgat  attgtgaaa  gaaagaagt  gccttctga  ccagatgtg  1560
tagaaggag  agtaacaga  gaagatgaa  aagctcaaa  gtctcgaag  atgtcggta  1620
attacaatg  tgagcagaa  caaatccga  tctgtaggg  gctctctga  ttggtgtct  1680
tttgtaaat  tgttcaata  agggatttt  aactatcta  gaaaagcca  aactattgg  1740
aaatgtgtt  atttagtga  acagaggcc  gccgcattg  aaatgagta  ccagaggat  1800
ttgttaatt  taataagaa  ttcttatca  gaatctatc  aagtgccat  aggatcgat  1860
ccagtaact  gaatccaca  gacttttgg  attgtggct  tcagattgt  gcaatgaat  1920
ttcagactc  gggtccaat  atggacctt  acacgggct  gtttcttca  aacggggga  1980
gtggttatg  tctaaggcc  tctataatg  gagatgaag  ttcttactt  agcgcaaat  2040
caaagggca  tctacctgg  gtgtctcct  tagctcttc  tatcaagat  atcagtggt  2100
agaatttcc  aaagcccaa  ggagcttgt  ccaaagggg  tgtcataga  ccctatgtt  2160
gtatagaga  acacggaat  ccagcggat  gttcggaac  aagaactaa  actgtacag  2220
aaaacagtg  taatcctat  tttgatgaa  cttttgagt  ccaagtaaa  ctacctgag  2280
tggccatga  ccgttttgt  gttctggat  atgactaca  tggggatga  tttataggg  2340
aatatacga  accatttga  tgtttgcag  ctggatatc  gcatgttcc  ctgcgttct  2400
ttgtgggtg  catcatgga  cacgtaacc  tttttgtcc  catagcaat  actaatcga  2460
gtggaggag  aaaggcaca  aagcgcagt  tttcagtga  aatggggaa  aaagttcgg  2520
aatatacca  gctcaggaa  atcggtctt  aaaccattg  tgacatctt  aaaatagcg  2580
ttcatccat  acgagaagc  atagatatg  gagaaaata  gcagaatgc  atcgtgtct  2640
ttaaggaac  atgtggact  cctccaatt  ccagtctga  gcagtgcct  ttaactctg  2700
catctcggc  catcaccag  gacaatact  cttcagtct  acttgtgat  aaagacagc  2760
ttccttacc  ggagcctct  ggtgcaatt  cagatgtgc  gaaaaagat  ctgactgct  2820
atgatctga  gattcaaga  agccggttt  tcatagaaa  ggcggacac  gtccaggaa  2880
agattgtac  gtgtcagaa  gcagggatg  agttccatg  agaacttca  aatttgggg  2940
caaaagaag  cttgaaggg  agaaaactc  acaaagcaa  tgagagctt  gcttggaac  3000
ttacagtat  gaagggcca  ggagatctg  tgaagaatg  caagaatga  gctatagaa  3060
acatgaagc  gatccagct  gcatgcctg  cctgtggac  gagtaaagc  cccagcagc  3120
gtgctgagg  caagagcaa  cgcagcctg  aagccatag  ggagaagga  agtagtgag  3180
agaatggga  gctgtgact  tgggcatta  cgacacgtt  acccatctt  tcaaggact  3240
tggtttctc  ttcttgttt  ctttcttta  atgttttat  agttcacaa  atggtgccc  3300
atatggggt  ttggacata  atattttca  aatgtcagt  tttcagtgt  gttaattta  3360
ctaaattaa  gcctttagt  tcagtgttt  aaattctga  acatgtgtc  acacccctg  3420
gtggatgcc  gtggaagag  gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtggc  3480
gagagagag  aagagagag  gagaaattc  gttaaaatc  attctgtgt  gcattattc  3540
tttagtgag  tattccttg  tcattttgg  acaattgtt  taatctgaa  ttctaaaga  3600
cacttactg  aacctgttg  tgtgtttaa  ttgacttct  tgcctttga  atttaattt  3660
gtgatctta  catagctta  tattgaagg  agccaaatt  atcaaagca  acatgtttt  3720
gtagattaa  tatagatta  aaaaattcc  aagaatcag  gtagaaata  aagtgaatg  3780
aagattaaa  agatgatga  aatttctaa  aagattagc  aggtcattt  ttcagtcag  3840
aaactttaa  aaatattta  taaataaaa  caattttta  gaagttttc  gtagtcatt  3900
actaaacat  tgatttcac  agaaaagct  atcataagt  aatttatac  tacctgtgt  3960
gctactctg  aacacactg  aagctctgt  gcaattagg  tttgatgtg  cataatatt  4020
ttgtataat  tcgagattt  taggaaggt  tcattcttc  aagctgaga  tctagcact  4080
attttctat  acagatatg  cagcttaga  gtgttggct  tgtttggat  taattttag  4140
ggtactaaa  tttaaaatt  aaagataat  gttcaacaa  atcatatca  cacattgag  4200
tgatataaa  tctgtgggt  cgataatat  tttgtgata  tttaagagc  aaccagtta  4260
cacacatct  tgatataac  ctaacacac  cagaaagca  acatgcaaa  agaaatgac  4320
aattagggt  catttataa  tgcatctag  taattttta  cctaatgtc  tcataaagt  4380
cttgagtgt  atgtttgtt  cctccaaca  aactaaatg  tctatggtt  tgaaagaat  4440
tatttattt  aagcattgc  tttattttg  aaagcttct  aattaattt  attaacaaa  4500
atgctaatt  ggggaaacc  agagaagat  attgttgaa  ttttgcaaa  ataaacatc  4560
cctat  4565



<210> 2070
<211> 997
<212> PRT
<213> Homo sapiens
<308> NP_006217
<400> 2070

Met Pro Ser Glu Lys Lys Ile Ser Ser Ala Asn Asp Cys Ile Ser Phe 
  1               5                  10                  15
Met Gln Ala Gly Cys Glu Leu Lys Lys Val Arg Pro Asn Ser Arg Ile 
             20                  25                  30
Tyr Asn Arg Phe Phe Thr Leu Asp Thr Asp Leu Gln Ala Leu Arg Trp 
         35                  40                  45
Glu Pro Ser Lys Lys Asp Leu Glu Lys Ala Lys Leu Asp Ile Ser Ala 
     50                  55                  60
Ile Lys Glu Ile Arg Leu Gly Lys Asn Thr Glu Thr Phe Thr Asn Asn 
 65                  70                  75                  80
Gly Leu Ala Asp Gln Ile Cys Glu Asp Cys Ala Phe Ser Ile Leu His 
                 85                  90                  95
Gly Glu Asn Tyr Glu Ser Leu Asp Leu Val Ala Asn Ser Ala Asp Val 
             100                105                110
Ala Asn Ile Trp Val Ser Gly Leu Arg Tyr Leu Val Ser Arg Ser Lys 
         115                120                125
Gln Pro Leu Asp Phe Met Glu Gly Asn Gln Asn Thr Pro Arg Phe Met 
     130                135                140
Trp Leu Lys Thr Val Phe Glu Ala Ala Asp Val Asp Gly Asn Gly Ile 
 145                150                155                160
Met Leu Glu Asp Thr Ser Val Glu Leu Ile Lys Gln Leu Asn Pro Thr 
                 165                170                175
Leu Lys Glu Ala Lys Ile Arg Leu Lys Phe Lys Glu Ile Gln Lys Ser 
             180                185                190
Lys Glu Lys Leu Thr Thr Arg Val Thr Glu Glu Glu Phe Cys Glu Ala 
         195                200                205
Phe Cys Glu Leu Cys Thr Arg Pro Glu Val Tyr Phe Leu Leu Val Gln 
     210                215                220
Ile Ser Lys Asn Lys Glu Tyr Leu Asp Ala Asn Asp Leu Met Leu Phe 
 225                230                235                240
Leu Glu Ala Glu Gln Gly Val Thr His Ile Thr Glu Asp Ile Cys Leu 
                 245                250                255
Asp Ile Ile Arg Arg Tyr Glu Leu Ser Glu Glu Gly Arg Gln Lys Gly 
             260                265                270
Phe Leu Ala Ile Asp Gly Phe Thr Gln Tyr Leu Leu Ser Ser Glu Cys 
         275                280                285
Asp Ile Phe Asp Pro Glu Gln Lys Lys Val Ala Gln Asp Met Thr Gln 
     290                295                300
Pro Leu Ser His Tyr Tyr Ile Asn Ala Ser His Asn Thr Tyr Leu Ile 
 305                310                315                320
Glu Asp Gln Phe Arg Gly Pro Ala Asp Ile Asn Gly Tyr Ile Arg Ala 
                 325                330                335
Leu Lys Met Gly Cys Arg Ser Val Glu Leu Asp Val Ser Asp Gly Ser 
             340                345                350
Asp Asn Glu Pro Ile Leu Cys Asn Arg Asn Asn Met Thr Thr His Val 
         355                360                365
Ser Phe Arg Ser Val Ile Glu Val Ile Asn Lys Phe Ala Phe Val Ala 
     370                375                380
Ser Glu Tyr Pro Leu Ile Leu Cys Leu Gly Asn His Cys Ser Leu Pro 
 385                390                395                400
Gln Gln Lys Val Met Ala Gln Gln Met Lys Lys Val Phe Gly Asn Lys 
                 405                410                415
Leu Tyr Thr Glu Ala Pro Leu Pro Ser Glu Ser Tyr Leu Pro Ser Pro 
             420                425                430
Glu Lys Leu Lys Arg Met Ile Ile Val Lys Gly Lys Lys Leu Pro Ser 
         435                440                445
Asp Pro Asp Val Leu Glu Gly Glu Val Thr Asp Glu Asp Glu Glu Ala 
     450                455                460
Gln Met Ser Arg Arg Met Ser Val Asp Tyr Asn Gly Glu Gln Lys Gln 
 465                470                475                480
Ile Arg Leu Cys Arg Glu Leu Ser Asp Leu Val Ser Ile Cys Lys Ser 
                 485                490                495
Val Gln Tyr Arg Asp Phe Glu Leu Ser Met Lys Ser Gln Asn Tyr Trp 
             500                505                510
Glu Met Cys Ser Phe Ser Glu Thr Glu Ala Ser Arg Ile Ala Asn Glu 
         515                520                525
Tyr Pro Glu Asp Phe Val Asn Tyr Asn Lys Lys Phe Leu Ser Arg Ile 
     530                535                540
Tyr Pro Ser Ala Met Arg Ile Asp Ser Ser Asn Leu Asn Pro Gln Asp 
 545                550                555                560
Phe Trp Asn Cys Gly Cys Gln Ile Val Ala Met Asn Phe Gln Thr Pro 
                 565                570                575
Gly Pro Met Met Asp Leu His Thr Gly Trp Phe Leu Gln Asn Gly Gly 
             580                585                590
Cys Gly Tyr Val Leu Arg Pro Ser Ile Met Arg Asp Glu Val Ser Tyr 
         595                600                605
Phe Ser Ala Asn Thr Lys Gly Ile Leu Pro Gly Val Ser Pro Leu Ala 
     610                615                620
Leu His Ile Lys Ile Ile Ser Gly Gln Asn Phe Pro Lys Pro Lys Gly 
 625                630                635                640
Ala Cys Ala Lys Gly Asp Val Ile Asp Pro Tyr Val Cys Ile Glu Ile 
                 645                650                655
His Gly Ile Pro Ala Asp Cys Ser Glu Gln Arg Thr Lys Thr Val Gln 
             660                665                670
Gln Asn Ser Asp Asn Pro Ile Phe Asp Glu Thr Phe Glu Phe Gln Val 
         675                680                685
Asn Leu Pro Glu Leu Ala Met Ile Arg Phe Val Val Leu Asp Asp Asp 
     690                695                700
Tyr Ile Gly Asp Glu Phe Ile Gly Gln Tyr Thr Ile Pro Phe Glu Cys 
 705                710                715                720
Leu Gln Pro Gly Tyr Arg His Val Pro Leu Arg Ser Phe Val Gly Asp 
                 725                730                735
Ile Met Glu His Val Thr Leu Phe Val His Ile Ala Ile Thr Asn Arg 
             740                745                750
Ser Gly Gly Gly Lys Ala Gln Lys Arg Ser Leu Ser Val Arg Met Gly 
         755                760                765
Lys Lys Val Arg Glu Tyr Thr Met Leu Arg Asn Ile Gly Leu Lys Thr 
     770                775                780
Ile Asp Asp Ile Phe Lys Ile Ala Val His Pro Leu Arg Glu Ala Ile 
 785                790                795                800
Asp Met Arg Glu Asn Met Gln Asn Ala Ile Val Ser Ile Lys Glu Leu 
                 805                810                815
Cys Gly Leu Pro Pro Ile Ala Ser Leu Lys Gln Cys Leu Leu Thr Leu 
             820                825                830
Ser Ser Arg Leu Ile Thr Ser Asp Asn Thr Pro Ser Val Ser Leu Val 
         835                840                845
Met Lys Asp Ser Phe Pro Tyr Leu Glu Pro Leu Gly Ala Ile Pro Asp 
     850                855                860
Val Gln Lys Lys Met Leu Thr Ala Tyr Asp Leu Met Ile Gln Glu Ser 
 865                870                875                880
Arg Phe Leu Ile Glu Met Ala Asp Thr Val Gln Glu Lys Ile Val Gln 
                 885                890                895
Cys Gln Lys Ala Gly Met Glu Phe His Glu Glu Leu His Asn Leu Gly 
             900                905                910
Ala Lys Glu Gly Leu Lys Gly Arg Lys Leu Asn Lys Ala Thr Glu Ser 
         915                920                925
Phe Ala Trp Asn Ile Thr Val Leu Lys Gly Gln Gly Asp Leu Leu Lys 
     930                935                940
Asn Ala Lys Asn Glu Ala Ile Glu Asn Met Lys Gln Ile Gln Leu Ala 
 945                950                955                960
Cys Leu Ser Cys Gly Leu Ser Lys Ala Pro Ser Ser Ser Ala Glu Ala 
                 965                970                975
Lys Ser Lys Arg Ser Leu Glu Ala Ile Glu Glu Lys Glu Ser Ser Glu 
             980                985                990
Glu Asn Gly Lys Leu 
         995



<210> 2071
<211> 5233
<212> DNA
<213> Rattus norvegicus
<308> D45920
<400> 2071

aggcagccg  cgccgcact  cctgaggcc  ccgctccgc  tcggcgggc  ggtggctgg  60
ggccggtcc  cagtcgccg  tcgggccgc  cgcgtccag  cttcggagg  ttcggaggc  120
ccgggctcc  gcgcccgct  tcttttgtc  gcgcagagc  ggcgctcgc  tcccctcgc  180
ggtacctcc  gctgctttt  gcctgcttc  ccctcccgc  cacatcttc  ccccgcccc  240
gccgccggt  cgcgccggc  gctgacctc  tggaccaca  cccgaggac  cctctgccc  300
agtgatgtc  cctctctac  aagttgcgg  cgccgctgc  gccgccgtc  cgcgctgaa  360
caaagtcta  cggcgtttc  ttctggtgc  tgagcgcac  cttactcag  gctggacgc  420
gctggcggt  gtgctgtct  gccgggagc  tagaacgtg  ttggccatg  ctgagggcg  480
ggctagcag  gaggctccg  cgcctctcg  cgttgcggg  ggcgaagac  accctcgag  540
cggcgccga  gctgcctcc  gggacgctg  acccgaggc  tcggggggc  ggatgaggg  600
ccgtcgcag  ggggttgcg  tgccgggca  tgcgggggt  cccgcggat  gcgaggctg  660
cctcctgga  gcggcacga  cgacccccc  gcgcacgag  atcatcaag  atccttcaa  720
ccaaaaatg  ggtggcaga  agaaaacag  gtctttcag  agcatgcca  cggagaaga  780
gattagcag  gcccatgac  gcattagct  catgcaggc  ggctgcgag  tgaagaaag  840
gcgaccgaa  tctcgcatc  acaaccgat  tttcaccct  gacactgac  tccaggctc  900
acgctggga  ccttccaag  aagacctcg  aaaagccaa  ctggacatt  ctgccatca  960
agagatcag  ctggggaag  acacggaga  attcagaaa  aatggcctt  ctgaccaga  1020
ctgtgaaga  tgtgccttc  ccatactcc  tggggaaaa  tacgagtct  tggacctag  1080
tgccaattc  gcagatgta  caaacatct  ggtgtcggg  ttacggtac  tggtctctc  1140
cagtaagca  ccacttgac  ttatggagg  caaccagaa  acaccacgg  tcatgtggc  1200
gaaaacggt  tttgaagca  cagatgttg  tgggaatgg  attatgtta  aagatacct  1260
ggtggagtt  ataaaacaa  tcaacccta  tctgaagga  tctaagatc  ggttaaagt  1320
taaagaaat  cagaagagc  aagaaaaac  aactacccg  gtaacagaa  aggaattct  1380
tgaagcgtt  tgtgaactt  gcactagac  agaagtgta  ttcttactt  ttcagatat  1440
taagaacaa  gagtatctg  atgctaatg  cctcatgct  tttttagaa  ttgagcaag  1500
ggtcaccca  gtcactgag  atatgtgct  agacatcat  aggagatac  aactttctg  1560
agatggccg  cagaaaggc  tccttgcaa  tgatggctt  acccagtat  tattatctc  1620
agaatgcga  atttttgat  cagagcaaa  gaaggttgc  caagacatg  cccaaccct  1680
atctcacta  tatatcaat  cgtcccata  tacctacct  atagaagat  agttcaggg  1740
gccagctga  atcaatggg  atgtgaggg  tttgaagat  ggctgtcga  gcattgagc  1800
tgatgtaag  gacggtcca  ataatgaac  catcctgtg  aataggaac  acatggcca  1860
gctcctttc  tttcgaagt  ttctggagg  gataaataa  ttcgccttc  tcgcttcag  1920
gtacccact  attctctgc  tggggaatc  ctgttccct  ccacagcag  gggtcatgg  1980
tcagcagat  aaaaaggtg  ttggcaata  actttatac  gaagcacct  tgtcttcag  2040
atcctacct  ccgtcgcct  aaaaactaa  acatatgat  attgtgaaa  gaaagaaat  2100
gccttcgga  tcagatctg  tagagggag  agtgaccga  gaggatgaa  aagctgaga  2160
gtcccggag  gtgtcggga  attacaacg  tgagcagaa  catatctgg  tctgccgag  2220
gctctctga  ttggtatcc  tctgtaaat  cgttcagta  agggatttt  aactgtcta  2280
gaaaaccca  aactactgg  aaatttgtt  atttagtga  acattggcc  gccggatcg  2340
aaatgagta  ccagaggat  tcgtgaatt  taacaagaa  ttcttatca  gggtctacc  2400
tagtgccat  aggatagat  ccagtaatt  gaacccaca  gacttctgg  attgtggct  2460
tcagattgt  gcaatgaat  ttcaaactc  tggtccaat  atggacctc  acaccggct  2520
gtttcttca  aatgggggc  gtggctacg  cctcaggcc  tctatcatg  gagatgaag  2580
ttcgtactt  agtgcaaac  caaagggca  tgtccctgg  gtgtctccc  tgcttcttc  2640
catcaagat  atcagtggt  agaacttcc  aaagcccaa  ggagcttgt  ccaaagggg  2700
tgtcataga  ccctacgtt  gtgtagaga  tcatggaat  ccagctgat  gctccgagc  2760
aagaactaa  actgtacaa  agaacagcg  taatcccat  ttcgatgaa  ctttcgagt  2820
tcaagtcaa  cttcccgag  tgaccatgg  ccgttttgt  attttggat  atgattaca  2880
tggagatga  ttcattggg  aatacacga  accgtttga  tgtctgcaa  ctgggtacc  2940
gcatgtccc  ttgcgctcc  ttgtggggg  tatcatgga  catgtgacc  tttttgtcc  3000
catagcaat  accaatcgg  gtggcggag  aaaagcgca  aagcgaagt  tttccgtga  3060
aatggggaa  aaagttcga  aatacacca  gctcagaaa  atcggtctt  aaaccatag  3120
tgatatctt  aaaatagca  ttcatcctt  gcgagaagc  atagatatg  gagaaaaca  3180
gcagaacgc  atagtgtct  ttaaggagc  gtgtggact  ccaccgatt  ccagtctga  3240
acagtgcct  ttaaccctg  cctctcgtc  catcaccag  gatagtact  cctccgtgt  3300
tctggtgat  aaggactgc  ttccttacc  ggagcctct  ggcacaatt  cagatgtgc  3360
gaagaggat  ctggctgca  atgatctga  gattcaaga  agtcgggtc  tcatagaaa  3420
ggctgacac  gtccaggaa  aaattgtac  gtgtcagaa  gcagggatg  aattccatg  3480
agaacttca  aatctaggg  caaaggaag  cttgaaggg  agaaaactc  acaaggcca  3540
cgagagctt  gcttggaat  ttactgtat  gaagggaca  ggagacctg  tgaagaatg  3600
caagaatga  gccgtagag  acataaagc  gatccagct  gcctgtttg  cttgtggac  3660
gagtaaagg  cctggcagc  ctgcagagg  caagggcaa  cgcagcttg  aagccatag  3720
ggagaagga  agcagtgaa  agaacggga  gttgtgagc  gggcagtgc  caggccctt  3780
tccaacact  tggtttctc  ttcttctcg  tttgttttg  ttttacatt  ttcagatgt  3840
cacagaaat  atgcccttt  cggggtgtt  tacataaac  tatattttc  cagtgtcag  3900
attttactg  agttaattt  tctaagtta  aacttttag  agcagtgtt  taaactttg  3960
gctgtgagt  tatacttac  tgtggctgc  tgtgtgtgt  tgtgtgtgt  tgtttgtgt  4020
tgtgtgtgt  tgtgtgtgt  tgtgtgtga  agagagaga  agagagaga  agagagaga  4080
agagagaga  agtaagagt  cctgttaaa  tattctctg  cgcattgtt  gttttaata  4140
gttattctt  tatctttaa  atcatttgg  gatagttga  aatctgaat  ctaatgagc  4200
tttattata  ccccttgct  tcgttagtt  tacctctct  cctttgtca  ataatttgg  4260
gatctcagc  cagcttatg  ttgaagaaa  ccaaattta  aagagcaaa  gcgttttat  4320
gattacata  agatttaaa  gttcctaaa  attacatta  aaatgaaag  gaatagaaa  4380
atcttttaa  atcataatt  tggaaagat  aacaaattc  tttcttcat  agcaaaatc  4440
ttgagatat  tattaacta  aatcacatt  aggaagttt  tgtagctgt  tactgagca  4500
gtggtttcg  tagaagagc  gagtgcaga  aacctgtag  cactgggca  tactttgaa  4560
cccactaaa  gctctactg  actagcact  ttgatgtga  cataacact  agttgtgca  4620
tttcaaggt  tgcagaaag  cctcattct  ctgggccgg  agtatggaa  tcattttct  4680
ttaccagtg  tgggcagat  caagtgctt  gccaggact  gatctagta  agattacta  4740
atttaagtg  caacacctt  ttaaaataa  atattatca  gttgagctg  cataaattc  4800
gtaagtccg  taacatctt  ctgatgatt  gagaactaa  taattagac  acatgtatg  4860
tataatttt  aaacataca  taaaaacca  gagcaagtg  ctaattagg  tacatttat  4920
attatatct  gataatctt  ccctaatgt  ttcataaac  tcttaaatg  catgttcat  4980
cattaccac  aacagaact  aatgttcta  gattatgaa  gaatatatt  gtttaaaac  5040
ttgctttta  tttgaaaag  ttcttaatt  atttgatta  caaatatat  aatttgggg  5100
agcctagag  agataatca  tgaaatttt  caaatataa  catcctcta  agctactat  5160
ttatttctg  ctgttctta  tactactct  ttcttgtcg  acattacca  aagagtaaa  5220
atactgaaa  cag  5233



<210> 2072
<211> 1096
<212> PRT
<213> Rattus norvegicus
<308> BAA08351
<400> 2072

Met Ala Glu Gly Ala Ala Ser Arg Glu Ala Pro Ala Pro Leu Asp Val 
  1               5                  10                  15
Ala Gly Gly Glu Asp Asp Pro Arg Ala Gly Ala Asp Ala Ala Ser Gly 
             20                  25                  30
Asp Ala Ala Pro Glu Ala Ser Gly Gly Arg Met Arg Asp Arg Arg Ser 
         35                  40                  45
Gly Val Ala Leu Pro Gly Asn Ala Gly Val Pro Ala Asp Ser Glu Ala 
     50                  55                  60
Gly Leu Leu Glu Ala Ala Arg Ala Thr Pro Arg Arg Thr Ser Ile Ile 
 65                  70                  75                  80
Lys Asp Pro Ser Asn Gln Lys Cys Gly Gly Arg Lys Lys Thr Val Ser 
                 85                  90                  95
Phe Ser Ser Met Pro Ser Glu Lys Lys Ile Ser Ser Ala His Asp Cys 
             100                105                110
Ile Ser Phe Met Gln Ala Gly Cys Glu Leu Lys Lys Val Arg Pro Asn 
         115                120                125
Ser Arg Ile Tyr Asn Arg Phe Phe Thr Leu Asp Thr Asp Leu Gln Ala 
     130                135                140
Leu Arg Trp Glu Pro Ser Lys Lys Asp Leu Glu Lys Ala Lys Leu Asp 
 145                150                155                160
Ile Ser Ala Ile Lys Glu Ile Arg Leu Gly Lys Asn Thr Glu Thr Phe 
                 165                170                175
Arg Asn Asn Gly Leu Ala Asp Gln Ile Cys Glu Asp Cys Ala Phe Ser 
             180                185                190
Ile Leu His Gly Glu Asn Tyr Glu Ser Leu Asp Leu Val Ala Asn Ser 
         195                200                205
Ala Asp Val Ala Asn Ile Trp Val Ser Gly Leu Arg Tyr Leu Val Ser 
     210                215                220
Arg Ser Lys Gln Pro Leu Asp Phe Met Glu Gly Asn Gln Asn Thr Pro 
 225                230                235                240
Arg Phe Met Trp Leu Lys Thr Val Phe Glu Ala Ala Asp Val Asp Gly 
                 245                250                255
Asn Gly Ile Met Leu Glu Asp Thr Ser Val Glu Leu Ile Lys Gln Leu 
             260                265                270
Asn Pro Thr Leu Lys Glu Ser Lys Ile Arg Leu Lys Phe Lys Glu Ile 
         275                280                285
Gln Lys Ser Lys Glu Lys Leu Thr Thr Arg Val Thr Glu Glu Glu Phe 
     290                295                300
Cys Glu Ala Phe Cys Glu Leu Cys Thr Arg Pro Glu Val Tyr Phe Leu 
 305                310                315                320
Leu Val Gln Ile Ser Lys Asn Lys Glu Tyr Leu Asp Ala Asn Asp Leu 
                 325                330                335
Met Leu Phe Leu Glu Val Glu Gln Gly Val Thr His Val Thr Glu Asp 
             340                345                350
Met Cys Leu Asp Ile Ile Arg Arg Tyr Glu Leu Ser Glu Asp Gly Arg 
         355                360                365
Gln Lys Gly Phe Leu Ala Ile Asp Gly Phe Thr Gln Tyr Leu Leu Ser 
     370                375                380
Pro Glu Cys Asp Ile Phe Asp Pro Glu Gln Lys Lys Val Ala Gln Asp 
 385                390                395                400
Met Thr Gln Pro Leu Ser His Tyr Tyr Ile Asn Ala Ser His Asn Thr 
                 405                410                415
Tyr Leu Ile Glu Asp Gln Phe Arg Gly Pro Ala Asp Ile Asn Gly Tyr 
             420                425                430
Val Arg Ala Leu Lys Met Gly Cys Arg Ser Ile Glu Leu Asp Val Ser 
         435                440                445
Asp Gly Pro Asp Asn Glu Pro Ile Leu Cys Asn Arg Asn Asn Met Ala 
     450                455                460
Met Leu Leu Ser Phe Arg Ser Val Leu Glu Val Ile Asn Lys Phe Ala 
 465                470                475                480
Phe Val Ala Ser Glu Tyr Pro Leu Ile Leu Cys Leu Gly Asn His Cys 
                 485                490                495
Ser Leu Pro Gln Gln Arg Val Met Val Gln Gln Met Lys Lys Val Phe 
             500                505                510
Gly Asn Lys Leu Tyr Thr Glu Ala Pro Leu Ser Ser Glu Ser Tyr Leu 
         515                520                525
Pro Ser Pro Glu Lys Leu Lys His Met Ile Ile Val Lys Gly Lys Lys 
     530                535                540
Leu Pro Ser Glu Ser Asp Leu Leu Glu Gly Glu Val Thr Asp Glu Asp 
 545                550                555                560
Glu Glu Ala Glu Met Ser Arg Arg Val Ser Gly Asp Tyr Asn Gly Glu 
                 565                570                575
Gln Lys His Ile Trp Leu Cys Arg Glu Leu Ser Asp Leu Val Ser Ile 
             580                585                590
Cys Lys Ser Val Gln Tyr Arg Asp Phe Glu Leu Ser Met Lys Thr Gln 
         595                600                605
Asn Tyr Trp Glu Ile Cys Ser Phe Ser Glu Thr Leu Ala Ser Arg Ile 
     610                615                620
Ala Asn Glu Tyr Pro Glu Asp Phe Val Asn Tyr Asn Lys Lys Phe Leu 
 625                630                635                640
Ser Arg Val Tyr Pro Ser Ala Met Arg Ile Asp Ser Ser Asn Leu Asn 
                 645                650                655
Pro Gln Asp Phe Trp Asn Cys Gly Cys Gln Ile Val Ala Met Asn Phe 
             660                665                670
Gln Thr Pro Gly Pro Met Met Asp Leu His Thr Gly Trp Phe Leu Gln 
         675                680                685
Asn Gly Gly Cys Gly Tyr Val Leu Arg Pro Ser Ile Met Arg Asp Glu 
     690                695                700
Val Ser Tyr Phe Ser Ala Asn Thr Lys Gly Ile Val Pro Gly Val Ser 
 705                710                715                720
Pro Leu Leu Leu His Ile Lys Ile Ile Ser Gly Gln Asn Phe Pro Lys 
                 725                730                735
Pro Lys Gly Ala Cys Ala Lys Gly Asp Val Ile Asp Pro Tyr Val Cys 
             740                745                750
Val Glu Ile His Gly Ile Pro Ala Asp Cys Ser Glu Gln Arg Thr Lys 
         755                760                765
Thr Val Gln Gln Asn Ser Asp Asn Pro Ile Phe Asp Glu Thr Phe Glu 
     770                775                780
Phe Gln Val Asn Leu Pro Glu Leu Thr Met Val Arg Phe Val Ile Leu 
 785                790                795                800
Asp Asp Asp Tyr Ile Gly Asp Glu Phe Ile Gly Gln Tyr Thr Ile Pro 
                 805                810                815
Phe Glu Cys Leu Gln Pro Gly Tyr Arg His Val Pro Leu Arg Ser Phe 
             820                825                830
Val Gly Asp Ile Met Glu His Val Thr Leu Phe Val His Ile Ala Ile 
         835                840                845
Thr Asn Arg Ser Gly Gly Gly Lys Ala Gln Lys Arg Ser Leu Ser Val 
     850                855                860
Arg Met Gly Lys Lys Val Arg Glu Tyr Thr Met Leu Arg Asn Ile Gly 
 865                870                875                880
Leu Lys Thr Ile Asp Asp Ile Phe Lys Ile Ala Val His Pro Leu Arg 
                 885                890                895
Glu Ala Ile Asp Met Arg Glu Asn Met Gln Asn Ala Ile Val Ser Val 
             900                905                910
Lys Glu Leu Cys Gly Leu Pro Pro Ile Ala Ser Leu Lys Gln Cys Leu 
         915                920                925
Leu Thr Leu Ser Ser Arg Leu Ile Thr Ser Asp Ser Thr Pro Ser Val 
     930                935                940
Ser Leu Val Met Lys Asp Cys Phe Pro Tyr Leu Glu Pro Leu Gly Thr 
 945                950                955                960
Ile Pro Asp Val Gln Lys Arg Met Leu Ala Ala Tyr Asp Leu Met Ile 
                 965                970                975
Gln Glu Ser Arg Val Leu Ile Glu Met Ala Asp Thr Val Gln Glu Lys 
             980                985                990
Ile Val Gln Cys Gln Lys Ala Gly Met Glu Phe His Glu Glu Leu His 
         995                1000                1005
Asn Leu Gly Ala Lys Glu Gly Leu Lys Gly Arg Lys Leu Asn Lys Ala 
     1010                1015                1020
Ile Glu Ser Phe Ala Trp Asn Ile Thr Val Leu Lys Gly Gln Gly Asp 
 1025                1030                1035                1040
Leu Leu Lys Asn Ala Lys Asn Glu Ala Val Glu Asn Ile Lys Gln Ile 
                 1045                1050                1055
Gln Leu Ala Cys Leu Ser Cys Gly Leu Ser Lys Gly Pro Gly Ser Ala 
             1060                1065                1070
Ala Glu Ala Lys Gly Lys Arg Ser Leu Glu Ala Ile Glu Glu Lys Glu 
         1075                1080                1085
Ser Ser Glu Glu Asn Gly Lys Leu 
     1090                1095



<210> 2073
<211> 4565
<212> DNA
<213> Homo sapiens
<308> D42108
<400> 2073

gaattccgg  cagcatcat  aaggcacat  gattctctc  ttgaacaat  cagctgctg  60
aggggatgg  gaagggatg  cactggcaa  tcaagactg  ctttcctac  tcttcagtg  120
ctctttcac  aatatgaag  taaaaccag  atccttcaa  ccaaaaatg  ggtggaaga  180
agaaaaccg  gtctttcag  agcatgcca  cggaaaaga  aattagcag  gcaaatgac  240
gcatcagct  catgcaagc  ggctgtgag  tgaagaaag  ccggccaaa  tctcgcatt  300
acaaccgtt  tttcactct  gacacagac  ttcaagctc  tcgctggga  ccttcaaag  360
aagacctcg  gaaagccaa  cttgatatt  ctgccataa  agagatcag  ctggggaaa  420
acacggaaa  atttacaaa  aatggcctt  ctgaccaga  ctgtgagga  tgtgccttt  480
ccatactcc  cggggaaaa  tatgagtct  tggacctag  tgccaattc  gcagatgtg  540
caaacatct  ggtgtctgg  ttacggtac  tggtttctc  aagtaagca  cctcttgat  600
ttatggagg  caaccagaa  acaccacgg  tcatgtggt  gaaaacagt  tttgaagca  660
cagatgttg  tgggaatgg  attatgttg  aagacacct  tgtagagtt  ataaaacaa  720
tcaacccta  tctgaagga  gccaagatc  ggttaaagt  taaagaaat  cagaagagc  780
aggaaaaac  aaccacccg  gtgaccgaa  aggaatttt  tgaagcttt  tgtgaactt  840
gcaccaggc  agaagtgta  ttcttactt  tacagatat  taaaaacaa  gaatatttg  900
atgccaatg  tctcatgct  tttttagaa  ctgagcaag  agtcaccca  atcaccgag  960
atatatgct  agacatcat  aggagatac  aactttctg  agagggacg  caaaaaggg  1020
ttcttgcaa  tgatggctt  acccagtat  tattgtcat  agaatgtga  atttttgat  1080
ctgagcaaa  gaaggttgc  caagatatg  cccagccat  atctcacta  tatatcaat  1140
cctctcata  cacctatct  atagaagac  agttcaggg  gccagctga  atcaatggg  1200
acattagag  tttgaaaat  ggctgtcga  gcgttgaac  cgatgtaag  gatggttca  1260
ataatgaac  aatcctttg  aatcgaaat  acatgacaa  ccatgtttc  tttcgaagt  1320
tcatagagg  aataaataa  tttgccttt  ttgcttctg  atacccact  attctttgc  1380
tgggaaatc  ctgctcctt  ccgcagcag  aggtaatgg  tcaacagat  aaaaaggtc  1440
ttggcaata  actctatac  gaagcacct  tgccctcag  atcctacct  ccatcacca  1500
aaaaattaa  aagaatgat  attgtgaaa  gaaagaagt  gccttctga  ccagatgtg  1560
tagaaggag  agtaacaga  gaagatgaa  aagctcaaa  gtctcgaag  atgtcggta  1620
attacaatg  tgagcagaa  caaatccga  tctgtaggg  gctctctga  ttggtgtct  1680
tttgtaaat  tgttcaata  agggatttt  aactatcta  gaaaagcca  aactattgg  1740
aaatgtgtt  atttagtga  acagaggcc  gccgcattg  aaatgagta  ccagaggat  1800
ttgttaatt  taataagaa  ttcttatca  gaatctatc  aagtgccat  aggatcgat  1860
ccagtaact  gaatccaca  gacttttgg  attgtggct  tcagattgt  gcaatgaat  1920
ttcagactc  gggtccaat  atggacctt  acacgggct  gtttcttca  aacggggga  1980
gtggttatg  tctaaggcc  tctataatg  gagatgaag  ttcttactt  agcgcaaat  2040
caaagggca  tctacctgg  gtgtctcct  tagctcttc  tatcaagat  atcagtggt  2100
agaatttcc  aaagcccaa  ggagcttgt  ccaaagggg  tgtcataga  ccctatgtt  2160
gtatagaga  acacggaat  ccagcggat  gttcggaac  aagaactaa  actgtacag  2220
aaaacagtg  taatcctat  tttgatgaa  cttttgagt  ccaagtaaa  ctacctgag  2280
tggccatga  ccgttttgt  gttctggat  atgactaca  tggggatga  tttataggg  2340
aatatacga  accatttga  tgtttgcag  ctggatatc  gcatgttcc  ctgcgttct  2400
ttgtgggtg  catcatgga  cacgtaacc  tttttgtcc  catagcaat  actaatcga  2460
gtggaggag  aaaggcaca  aagcgcagt  tttcagtga  aatggggaa  aaagttcgg  2520
aatatacca  gctcaggaa  atcggtctt  aaaccattg  tgacatctt  aaaatagcg  2580
ttcatccat  acgagaagc  atagatatg  gagaaaata  gcagaatgc  atcgtgtct  2640
ttaaggaac  atgtggact  cctccaatt  ccagtctga  gcagtgcct  ttaactctg  2700
catctcggc  catcaccag  gacaatact  cttcagtct  acttgtgat  aaagacagc  2760
ttccttacc  ggagcctct  ggtgcaatt  cagatgtgc  gaaaaagat  ctgactgct  2820
atgatctga  gattcaaga  agccggttt  tcatagaaa  ggcggacac  gtccaggaa  2880
agattgtac  gtgtcagaa  gcagggatg  agttccatg  agaacttca  aatttgggg  2940
caaaagaag  cttgaaggg  agaaaactc  acaaagcaa  tgagagctt  gcttggaac  3000
ttacagtat  gaagggcca  ggagatctg  tgaagaatg  caagaatga  gctatagaa  3060
acatgaagc  gatccagct  gcatgcctg  cctgtggac  gagtaaagc  cccagcagc  3120
gtgctgagg  caagagcaa  cgcagcctg  aagccatag  ggagaagga  agtagtgag  3180
agaatggga  gctgtgact  tgggcatta  cgacacgtt  acccatctt  tcaaggact  3240
tggtttctc  ttcttgttt  ctttcttta  atgttttat  agttcacaa  atggtgccc  3300
atatggggt  ttggacata  atattttca  aatgtcagt  tttcagtgt  gttaattta  3360
ctaaattaa  gcctttagt  tcagtgttt  aaattctga  acatgtgtc  acacccctg  3420
gtggatgcc  gtggaagag  gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtggc  3480
gagagagag  aagagagag  gagaaattc  gttaaaatc  attctgtgt  gcattattc  3540
tttagtgag  tattccttg  tcattttgg  acaattgtt  taatctgaa  ttctaaaga  3600
cacttactg  aacctgttg  tgtgtttaa  ttgacttct  tgcctttga  atttaattt  3660
gtgatctta  catagctta  tattgaagg  agccaaatt  atcaaagca  acatgtttt  3720
gtagattaa  tatagatta  aaaaattcc  aagaatcag  gtagaaata  aagtgaatg  3780
aagattaaa  agatgatga  aatttctaa  aagattagc  aggtcattt  ttcagtcag  3840
aaactttaa  aaatattta  taaataaaa  caattttta  gaagttttc  gtagtcatt  3900
actaaacat  tgatttcac  agaaaagct  atcataagt  aatttatac  tacctgtgt  3960
gctactctg  aacacactg  aagctctgt  gcaattagg  tttgatgtg  cataatatt  4020
ttgtataat  tcgagattt  taggaaggt  tcattcttc  aagctgaga  tctagcact  4080
attttctat  acagatatg  cagcttaga  gtgttggct  tgtttggat  taattttag  4140
ggtactaaa  tttaaaatt  aaagataat  gttcaacaa  atcatatca  cacattgag  4200
tgatataaa  tctgtgggt  cgataatat  tttgtgata  tttaagagc  aaccagtta  4260
cacacatct  tgatataac  ctaacacac  cagaaagca  acatgcaaa  agaaatgac  4320
aattagggt  catttataa  tgcatctag  taattttta  cctaatgtc  tcataaagt  4380
cttgagtgt  atgtttgtt  cctccaaca  aactaaatg  tctatggtt  tgaaagaat  4440
tatttattt  aagcattgc  tttattttg  aaagcttct  aattaattt  attaacaaa  4500
atgctaatt  ggggaaacc  agagaagat  attgttgaa  ttttgcaaa  ataaacatc  4560
cctat  4565



<210> 2074
<211> 997
<212> PRT
<213> Homo sapiens
<308> NP_006217
<400> 2074

Met Pro Ser Glu Lys Lys Ile Ser Ser Ala Asn Asp Cys Ile Ser Phe 
  1               5                  10                  15
Met Gln Ala Gly Cys Glu Leu Lys Lys Val Arg Pro Asn Ser Arg Ile 
             20                  25                  30
Tyr Asn Arg Phe Phe Thr Leu Asp Thr Asp Leu Gln Ala Leu Arg Trp 
         35                  40                  45
Glu Pro Ser Lys Lys Asp Leu Glu Lys Ala Lys Leu Asp Ile Ser Ala 
     50                  55                  60
Ile Lys Glu Ile Arg Leu Gly Lys Asn Thr Glu Thr Phe Thr Asn Asn 
 65                  70                  75                  80
Gly Leu Ala Asp Gln Ile Cys Glu Asp Cys Ala Phe Ser Ile Leu His 
                 85                  90                  95
Gly Glu Asn Tyr Glu Ser Leu Asp Leu Val Ala Asn Ser Ala Asp Val 
             100                105                110
Ala Asn Ile Trp Val Ser Gly Leu Arg Tyr Leu Val Ser Arg Ser Lys 
         115                120                125
Gln Pro Leu Asp Phe Met Glu Gly Asn Gln Asn Thr Pro Arg Phe Met 
     130                135                140
Trp Leu Lys Thr Val Phe Glu Ala Ala Asp Val Asp Gly Asn Gly Ile 
 145                150                155                160
Met Leu Glu Asp Thr Ser Val Glu Leu Ile Lys Gln Leu Asn Pro Thr 
                 165                170                175
Leu Lys Glu Ala Lys Ile Arg Leu Lys Phe Lys Glu Ile Gln Lys Ser 
             180                185                190
Lys Glu Lys Leu Thr Thr Arg Val Thr Glu Glu Glu Phe Cys Glu Ala 
         195                200                205
Phe Cys Glu Leu Cys Thr Arg Pro Glu Val Tyr Phe Leu Leu Val Gln 
     210                215                220
Ile Ser Lys Asn Lys Glu Tyr Leu Asp Ala Asn Asp Leu Met Leu Phe 
 225                230                235                240
Leu Glu Ala Glu Gln Gly Val Thr His Ile Thr Glu Asp Ile Cys Leu 
                 245                250                255
Asp Ile Ile Arg Arg Tyr Glu Leu Ser Glu Glu Gly Arg Gln Lys Gly 
             260                265                270
Phe Leu Ala Ile Asp Gly Phe Thr Gln Tyr Leu Leu Ser Ser Glu Cys 
         275                280                285
Asp Ile Phe Asp Pro Glu Gln Lys Lys Val Ala Gln Asp Met Thr Gln 
     290                295                300
Pro Leu Ser His Tyr Tyr Ile Asn Ala Ser His Asn Thr Tyr Leu Ile 
 305                310                315                320
Glu Asp Gln Phe Arg Gly Pro Ala Asp Ile Asn Gly Tyr Ile Arg Ala 
                 325                330                335
Leu Lys Met Gly Cys Arg Ser Val Glu Leu Asp Val Ser Asp Gly Ser 
             340                345                350
Asp Asn Glu Pro Ile Leu Cys Asn Arg Asn Asn Met Thr Thr His Val 
         355                360                365
Ser Phe Arg Ser Val Ile Glu Val Ile Asn Lys Phe Ala Phe Val Ala 
     370                375                380
Ser Glu Tyr Pro Leu Ile Leu Cys Leu Gly Asn His Cys Ser Leu Pro 
 385                390                395                400
Gln Gln Lys Val Met Ala Gln Gln Met Lys Lys Val Phe Gly Asn Lys 
                 405                410                415
Leu Tyr Thr Glu Ala Pro Leu Pro Ser Glu Ser Tyr Leu Pro Ser Pro 
             420                425                430
Glu Lys Leu Lys Arg Met Ile Ile Val Lys Gly Lys Lys Leu Pro Ser 
         435                440                445
Asp Pro Asp Val Leu Glu Gly Glu Val Thr Asp Glu Asp Glu Glu Ala 
     450                455                460
Gln Met Ser Arg Arg Met Ser Val Asp Tyr Asn Gly Glu Gln Lys Gln 
 465                470                475                480
Ile Arg Leu Cys Arg Glu Leu Ser Asp Leu Val Ser Ile Cys Lys Ser 
                 485                490                495
Val Gln Tyr Arg Asp Phe Glu Leu Ser Met Lys Ser Gln Asn Tyr Trp 
             500                505                510
Glu Met Cys Ser Phe Ser Glu Thr Glu Ala Ser Arg Ile Ala Asn Glu 
         515                520                525
Tyr Pro Glu Asp Phe Val Asn Tyr Asn Lys Lys Phe Leu Ser Arg Ile 
     530                535                540
Tyr Pro Ser Ala Met Arg Ile Asp Ser Ser Asn Leu Asn Pro Gln Asp 
 545                550                555                560
Phe Trp Asn Cys Gly Cys Gln Ile Val Ala Met Asn Phe Gln Thr Pro 
                 565                570                575
Gly Pro Met Met Asp Leu His Thr Gly Trp Phe Leu Gln Asn Gly Gly 
             580                585                590
Cys Gly Tyr Val Leu Arg Pro Ser Ile Met Arg Asp Glu Val Ser Tyr 
         595                600                605
Phe Ser Ala Asn Thr Lys Gly Ile Leu Pro Gly Val Ser Pro Leu Ala 
     610                615                620
Leu His Ile Lys Ile Ile Ser Gly Gln Asn Phe Pro Lys Pro Lys Gly 
 625                630                635                640
Ala Cys Ala Lys Gly Asp Val Ile Asp Pro Tyr Val Cys Ile Glu Ile 
                 645                650                655
His Gly Ile Pro Ala Asp Cys Ser Glu Gln Arg Thr Lys Thr Val Gln 
             660                665                670
Gln Asn Ser Asp Asn Pro Ile Phe Asp Glu Thr Phe Glu Phe Gln Val 
         675                680                685
Asn Leu Pro Glu Leu Ala Met Ile Arg Phe Val Val Leu Asp Asp Asp 
     690                695                700
Tyr Ile Gly Asp Glu Phe Ile Gly Gln Tyr Thr Ile Pro Phe Glu Cys 
 705                710                715                720
Leu Gln Pro Gly Tyr Arg His Val Pro Leu Arg Ser Phe Val Gly Asp 
                 725                730                735
Ile Met Glu His Val Thr Leu Phe Val His Ile Ala Ile Thr Asn Arg 
             740                745                750
Ser Gly Gly Gly Lys Ala Gln Lys Arg Ser Leu Ser Val Arg Met Gly 
         755                760                765
Lys Lys Val Arg Glu Tyr Thr Met Leu Arg Asn Ile Gly Leu Lys Thr 
     770                775                780
Ile Asp Asp Ile Phe Lys Ile Ala Val His Pro Leu Arg Glu Ala Ile 
 785                790                795                800
Asp Met Arg Glu Asn Met Gln Asn Ala Ile Val Ser Ile Lys Glu Leu 
                 805                810                815
Cys Gly Leu Pro Pro Ile Ala Ser Leu Lys Gln Cys Leu Leu Thr Leu 
             820                825                830
Ser Ser Arg Leu Ile Thr Ser Asp Asn Thr Pro Ser Val Ser Leu Val 
         835                840                845
Met Lys Asp Ser Phe Pro Tyr Leu Glu Pro Leu Gly Ala Ile Pro Asp 
     850                855                860
Val Gln Lys Lys Met Leu Thr Ala Tyr Asp Leu Met Ile Gln Glu Ser 
 865                870                875                880
Arg Phe Leu Ile Glu Met Ala Asp Thr Val Gln Glu Lys Ile Val Gln 
                 885                890                895
Cys Gln Lys Ala Gly Met Glu Phe His Glu Glu Leu His Asn Leu Gly 
             900                905                910
Ala Lys Glu Gly Leu Lys Gly Arg Lys Leu Asn Lys Ala Thr Glu Ser 
         915                920                925
Phe Ala Trp Asn Ile Thr Val Leu Lys Gly Gln Gly Asp Leu Leu Lys 
     930                935                940
Asn Ala Lys Asn Glu Ala Ile Glu Asn Met Lys Gln Ile Gln Leu Ala 
 945                950                955                960
Cys Leu Ser Cys Gly Leu Ser Lys Ala Pro Ser Ser Ser Ala Glu Ala 
                 965                970                975
Lys Ser Lys Arg Ser Leu Glu Ala Ile Glu Glu Lys Glu Ser Ser Glu 
             980                985                990
Glu Asn Gly Lys Leu 
         995



<210> 2075
<211> 5233
<212> DNA
<213> Rattus norvegicus
<308> D45920
<400> 2075

aggcagccg  cgccgcact  cctgaggcc  ccgctccgc  tcggcgggc  ggtggctgg  60
ggccggtcc  cagtcgccg  tcgggccgc  cgcgtccag  cttcggagg  ttcggaggc  120
ccgggctcc  gcgcccgct  tcttttgtc  gcgcagagc  ggcgctcgc  tcccctcgc  180
ggtacctcc  gctgctttt  gcctgcttc  ccctcccgc  cacatcttc  ccccgcccc  240
gccgccggt  cgcgccggc  gctgacctc  tggaccaca  cccgaggac  cctctgccc  300
agtgatgtc  cctctctac  aagttgcgg  cgccgctgc  gccgccgtc  cgcgctgaa  360
caaagtcta  cggcgtttc  ttctggtgc  tgagcgcac  cttactcag  gctggacgc  420
gctggcggt  gtgctgtct  gccgggagc  tagaacgtg  ttggccatg  ctgagggcg  480
ggctagcag  gaggctccg  cgcctctcg  cgttgcggg  ggcgaagac  accctcgag  540
cggcgccga  gctgcctcc  gggacgctg  acccgaggc  tcggggggc  ggatgaggg  600
ccgtcgcag  ggggttgcg  tgccgggca  tgcgggggt  cccgcggat  gcgaggctg  660
cctcctgga  gcggcacga  cgacccccc  gcgcacgag  atcatcaag  atccttcaa  720
ccaaaaatg  ggtggcaga  agaaaacag  gtctttcag  agcatgcca  cggagaaga  780
gattagcag  gcccatgac  gcattagct  catgcaggc  ggctgcgag  tgaagaaag  840
gcgaccgaa  tctcgcatc  acaaccgat  tttcaccct  gacactgac  tccaggctc  900
acgctggga  ccttccaag  aagacctcg  aaaagccaa  ctggacatt  ctgccatca  960
agagatcag  ctggggaag  acacggaga  attcagaaa  aatggcctt  ctgaccaga  1020
ctgtgaaga  tgtgccttc  ccatactcc  tggggaaaa  tacgagtct  tggacctag  1080
tgccaattc  gcagatgta  caaacatct  ggtgtcggg  ttacggtac  tggtctctc  1140
cagtaagca  ccacttgac  ttatggagg  caaccagaa  acaccacgg  tcatgtggc  1200
gaaaacggt  tttgaagca  cagatgttg  tgggaatgg  attatgtta  aagatacct  1260
ggtggagtt  ataaaacaa  tcaacccta  tctgaagga  tctaagatc  ggttaaagt  1320
taaagaaat  cagaagagc  aagaaaaac  aactacccg  gtaacagaa  aggaattct  1380
tgaagcgtt  tgtgaactt  gcactagac  agaagtgta  ttcttactt  ttcagatat  1440
taagaacaa  gagtatctg  atgctaatg  cctcatgct  tttttagaa  ttgagcaag  1500
ggtcaccca  gtcactgag  atatgtgct  agacatcat  aggagatac  aactttctg  1560
agatggccg  cagaaaggc  tccttgcaa  tgatggctt  acccagtat  tattatctc  1620
agaatgcga  atttttgat  cagagcaaa  gaaggttgc  caagacatg  cccaaccct  1680
atctcacta  tatatcaat  cgtcccata  tacctacct  atagaagat  agttcaggg  1740
gccagctga  atcaatggg  atgtgaggg  tttgaagat  ggctgtcga  gcattgagc  1800
tgatgtaag  gacggtcca  ataatgaac  catcctgtg  aataggaac  acatggcca  1860
gctcctttc  tttcgaagt  ttctggagg  gataaataa  ttcgccttc  tcgcttcag  1920
gtacccact  attctctgc  tggggaatc  ctgttccct  ccacagcag  gggtcatgg  1980
tcagcagat  aaaaaggtg  ttggcaata  actttatac  gaagcacct  tgtcttcag  2040
atcctacct  ccgtcgcct  aaaaactaa  acatatgat  attgtgaaa  gaaagaaat  2100
gccttcgga  tcagatctg  tagagggag  agtgaccga  gaggatgaa  aagctgaga  2160
gtcccggag  gtgtcggga  attacaacg  tgagcagaa  catatctgg  tctgccgag  2220
gctctctga  ttggtatcc  tctgtaaat  cgttcagta  agggatttt  aactgtcta  2280
gaaaaccca  aactactgg  aaatttgtt  atttagtga  acattggcc  gccggatcg  2340
aaatgagta  ccagaggat  tcgtgaatt  taacaagaa  ttcttatca  gggtctacc  2400
tagtgccat  aggatagat  ccagtaatt  gaacccaca  gacttctgg  attgtggct  2460
tcagattgt  gcaatgaat  ttcaaactc  tggtccaat  atggacctc  acaccggct  2520
gtttcttca  aatgggggc  gtggctacg  cctcaggcc  tctatcatg  gagatgaag  2580
ttcgtactt  agtgcaaac  caaagggca  tgtccctgg  gtgtctccc  tgcttcttc  2640
catcaagat  atcagtggt  agaacttcc  aaagcccaa  ggagcttgt  ccaaagggg  2700
tgtcataga  ccctacgtt  gtgtagaga  tcatggaat  ccagctgat  gctccgagc  2760
aagaactaa  actgtacaa  agaacagcg  taatcccat  ttcgatgaa  ctttcgagt  2820
tcaagtcaa  cttcccgag  tgaccatgg  ccgttttgt  attttggat  atgattaca  2880
tggagatga  ttcattggg  aatacacga  accgtttga  tgtctgcaa  ctgggtacc  2940
gcatgtccc  ttgcgctcc  ttgtggggg  tatcatgga  catgtgacc  tttttgtcc  3000
catagcaat  accaatcgg  gtggcggag  aaaagcgca  aagcgaagt  tttccgtga  3060
aatggggaa  aaagttcga  aatacacca  gctcagaaa  atcggtctt  aaaccatag  3120
tgatatctt  aaaatagca  ttcatcctt  gcgagaagc  atagatatg  gagaaaaca  3180
gcagaacgc  atagtgtct  ttaaggagc  gtgtggact  ccaccgatt  ccagtctga  3240
acagtgcct  ttaaccctg  cctctcgtc  catcaccag  gatagtact  cctccgtgt  3300
tctggtgat  aaggactgc  ttccttacc  ggagcctct  ggcacaatt  cagatgtgc  3360
gaagaggat  ctggctgca  atgatctga  gattcaaga  agtcgggtc  tcatagaaa  3420
ggctgacac  gtccaggaa  aaattgtac  gtgtcagaa  gcagggatg  aattccatg  3480
agaacttca  aatctaggg  caaaggaag  cttgaaggg  agaaaactc  acaaggcca  3540
cgagagctt  gcttggaat  ttactgtat  gaagggaca  ggagacctg  tgaagaatg  3600
caagaatga  gccgtagag  acataaagc  gatccagct  gcctgtttg  cttgtggac  3660
gagtaaagg  cctggcagc  ctgcagagg  caagggcaa  cgcagcttg  aagccatag  3720
ggagaagga  agcagtgaa  agaacggga  gttgtgagc  gggcagtgc  caggccctt  3780
tccaacact  tggtttctc  ttcttctcg  tttgttttg  ttttacatt  ttcagatgt  3840
cacagaaat  atgcccttt  cggggtgtt  tacataaac  tatattttc  cagtgtcag  3900
attttactg  agttaattt  tctaagtta  aacttttag  agcagtgtt  taaactttg  3960
gctgtgagt  tatacttac  tgtggctgc  tgtgtgtgt  tgtgtgtgt  tgtttgtgt  4020
tgtgtgtgt  tgtgtgtgt  tgtgtgtga  agagagaga  agagagaga  agagagaga  4080
agagagaga  agtaagagt  cctgttaaa  tattctctg  cgcattgtt  gttttaata  4140
gttattctt  tatctttaa  atcatttgg  gatagttga  aatctgaat  ctaatgagc  4200
tttattata  ccccttgct  tcgttagtt  tacctctct  cctttgtca  ataatttgg  4260
gatctcagc  cagcttatg  ttgaagaaa  ccaaattta  aagagcaaa  gcgttttat  4320
gattacata  agatttaaa  gttcctaaa  attacatta  aaatgaaag  gaatagaaa  4380
atcttttaa  atcataatt  tggaaagat  aacaaattc  tttcttcat  agcaaaatc  4440
ttgagatat  tattaacta  aatcacatt  aggaagttt  tgtagctgt  tactgagca  4500
gtggtttcg  tagaagagc  gagtgcaga  aacctgtag  cactgggca  tactttgaa  4560
cccactaaa  gctctactg  actagcact  ttgatgtga  cataacact  agttgtgca  4620
tttcaaggt  tgcagaaag  cctcattct  ctgggccgg  agtatggaa  tcattttct  4680
ttaccagtg  tgggcagat  caagtgctt  gccaggact  gatctagta  agattacta  4740
atttaagtg  caacacctt  ttaaaataa  atattatca  gttgagctg  cataaattc  4800
gtaagtccg  taacatctt  ctgatgatt  gagaactaa  taattagac  acatgtatg  4860
tataatttt  aaacataca  taaaaacca  gagcaagtg  ctaattagg  tacatttat  4920
attatatct  gataatctt  ccctaatgt  ttcataaac  tcttaaatg  catgttcat  4980
cattaccac  aacagaact  aatgttcta  gattatgaa  gaatatatt  gtttaaaac  5040
ttgctttta  tttgaaaag  ttcttaatt  atttgatta  caaatatat  aatttgggg  5100
agcctagag  agataatca  tgaaatttt  caaatataa  catcctcta  agctactat  5160
ttatttctg  ctgttctta  tactactct  ttcttgtcg  acattacca  aagagtaaa  5220
atactgaaa  cag  5233



<210> 2076
<211> 1096
<212> PRT
<213> Rattus norvegicus
<308> BAA08351
<400> 2076

Met Ala Glu Gly Ala Ala Ser Arg Glu Ala Pro Ala Pro Leu Asp Val 
  1               5                  10                  15
Ala Gly Gly Glu Asp Asp Pro Arg Ala Gly Ala Asp Ala Ala Ser Gly 
             20                  25                  30
Asp Ala Ala Pro Glu Ala Ser Gly Gly Arg Met Arg Asp Arg Arg Ser 
         35                  40                  45
Gly Val Ala Leu Pro Gly Asn Ala Gly Val Pro Ala Asp Ser Glu Ala 
     50                  55                  60
Gly Leu Leu Glu Ala Ala Arg Ala Thr Pro Arg Arg Thr Ser Ile Ile 
 65                  70                  75                  80
Lys Asp Pro Ser Asn Gln Lys Cys Gly Gly Arg Lys Lys Thr Val Ser 
                 85                  90                  95
Phe Ser Ser Met Pro Ser Glu Lys Lys Ile Ser Ser Ala His Asp Cys 
             100                105                110
Ile Ser Phe Met Gln Ala Gly Cys Glu Leu Lys Lys Val Arg Pro Asn 
         115                120                125
Ser Arg Ile Tyr Asn Arg Phe Phe Thr Leu Asp Thr Asp Leu Gln Ala 
     130                135                140
Leu Arg Trp Glu Pro Ser Lys Lys Asp Leu Glu Lys Ala Lys Leu Asp 
 145                150                155                160
Ile Ser Ala Ile Lys Glu Ile Arg Leu Gly Lys Asn Thr Glu Thr Phe 
                 165                170                175
Arg Asn Asn Gly Leu Ala Asp Gln Ile Cys Glu Asp Cys Ala Phe Ser 
             180                185                190
Ile Leu His Gly Glu Asn Tyr Glu Ser Leu Asp Leu Val Ala Asn Ser 
         195                200                205
Ala Asp Val Ala Asn Ile Trp Val Ser Gly Leu Arg Tyr Leu Val Ser 
     210                215                220
Arg Ser Lys Gln Pro Leu Asp Phe Met Glu Gly Asn Gln Asn Thr Pro 
 225                230                235                240
Arg Phe Met Trp Leu Lys Thr Val Phe Glu Ala Ala Asp Val Asp Gly 
                 245                250                255
Asn Gly Ile Met Leu Glu Asp Thr Ser Val Glu Leu Ile Lys Gln Leu 
             260                265                270
Asn Pro Thr Leu Lys Glu Ser Lys Ile Arg Leu Lys Phe Lys Glu Ile 
         275                280                285
Gln Lys Ser Lys Glu Lys Leu Thr Thr Arg Val Thr Glu Glu Glu Phe 
     290                295                300
Cys Glu Ala Phe Cys Glu Leu Cys Thr Arg Pro Glu Val Tyr Phe Leu 
 305                310                315                320
Leu Val Gln Ile Ser Lys Asn Lys Glu Tyr Leu Asp Ala Asn Asp Leu 
                 325                330                335
Met Leu Phe Leu Glu Val Glu Gln Gly Val Thr His Val Thr Glu Asp 
             340                345                350
Met Cys Leu Asp Ile Ile Arg Arg Tyr Glu Leu Ser Glu Asp Gly Arg 
         355                360                365
Gln Lys Gly Phe Leu Ala Ile Asp Gly Phe Thr Gln Tyr Leu Leu Ser 
     370                375                380
Pro Glu Cys Asp Ile Phe Asp Pro Glu Gln Lys Lys Val Ala Gln Asp 
 385                390                395                400
Met Thr Gln Pro Leu Ser His Tyr Tyr Ile Asn Ala Ser His Asn Thr 
                 405                410                415
Tyr Leu Ile Glu Asp Gln Phe Arg Gly Pro Ala Asp Ile Asn Gly Tyr 
             420                425                430
Val Arg Ala Leu Lys Met Gly Cys Arg Ser Ile Glu Leu Asp Val Ser 
         435                440                445
Asp Gly Pro Asp Asn Glu Pro Ile Leu Cys Asn Arg Asn Asn Met Ala 
     450                455                460
Met Leu Leu Ser Phe Arg Ser Val Leu Glu Val Ile Asn Lys Phe Ala 
 465                470                475                480
Phe Val Ala Ser Glu Tyr Pro Leu Ile Leu Cys Leu Gly Asn His Cys 
                 485                490                495
Ser Leu Pro Gln Gln Arg Val Met Val Gln Gln Met Lys Lys Val Phe 
             500                505                510
Gly Asn Lys Leu Tyr Thr Glu Ala Pro Leu Ser Ser Glu Ser Tyr Leu 
         515                520                525
Pro Ser Pro Glu Lys Leu Lys His Met Ile Ile Val Lys Gly Lys Lys 
     530                535                540
Leu Pro Ser Glu Ser Asp Leu Leu Glu Gly Glu Val Thr Asp Glu Asp 
 545                550                555                560
Glu Glu Ala Glu Met Ser Arg Arg Val Ser Gly Asp Tyr Asn Gly Glu 
                 565                570                575
Gln Lys His Ile Trp Leu Cys Arg Glu Leu Ser Asp Leu Val Ser Ile 
             580                585                590
Cys Lys Ser Val Gln Tyr Arg Asp Phe Glu Leu Ser Met Lys Thr Gln 
         595                600                605
Asn Tyr Trp Glu Ile Cys Ser Phe Ser Glu Thr Leu Ala Ser Arg Ile 
     610                615                620
Ala Asn Glu Tyr Pro Glu Asp Phe Val Asn Tyr Asn Lys Lys Phe Leu 
 625                630                635                640
Ser Arg Val Tyr Pro Ser Ala Met Arg Ile Asp Ser Ser Asn Leu Asn 
                 645                650                655
Pro Gln Asp Phe Trp Asn Cys Gly Cys Gln Ile Val Ala Met Asn Phe 
             660                665                670
Gln Thr Pro Gly Pro Met Met Asp Leu His Thr Gly Trp Phe Leu Gln 
         675                680                685
Asn Gly Gly Cys Gly Tyr Val Leu Arg Pro Ser Ile Met Arg Asp Glu 
     690                695                700
Val Ser Tyr Phe Ser Ala Asn Thr Lys Gly Ile Val Pro Gly Val Ser 
 705                710                715                720
Pro Leu Leu Leu His Ile Lys Ile Ile Ser Gly Gln Asn Phe Pro Lys 
                 725                730                735
Pro Lys Gly Ala Cys Ala Lys Gly Asp Val Ile Asp Pro Tyr Val Cys 
             740                745                750
Val Glu Ile His Gly Ile Pro Ala Asp Cys Ser Glu Gln Arg Thr Lys 
         755                760                765
Thr Val Gln Gln Asn Ser Asp Asn Pro Ile Phe Asp Glu Thr Phe Glu 
     770                775                780
Phe Gln Val Asn Leu Pro Glu Leu Thr Met Val Arg Phe Val Ile Leu 
 785                790                795                800
Asp Asp Asp Tyr Ile Gly Asp Glu Phe Ile Gly Gln Tyr Thr Ile Pro 
                 805                810                815
Phe Glu Cys Leu Gln Pro Gly Tyr Arg His Val Pro Leu Arg Ser Phe 
             820                825                830
Val Gly Asp Ile Met Glu His Val Thr Leu Phe Val His Ile Ala Ile 
         835                840                845
Thr Asn Arg Ser Gly Gly Gly Lys Ala Gln Lys Arg Ser Leu Ser Val 
     850                855                860
Arg Met Gly Lys Lys Val Arg Glu Tyr Thr Met Leu Arg Asn Ile Gly 
 865                870                875                880
Leu Lys Thr Ile Asp Asp Ile Phe Lys Ile Ala Val His Pro Leu Arg 
                 885                890                895
Glu Ala Ile Asp Met Arg Glu Asn Met Gln Asn Ala Ile Val Ser Val 
             900                905                910
Lys Glu Leu Cys Gly Leu Pro Pro Ile Ala Ser Leu Lys Gln Cys Leu 
         915                920                925
Leu Thr Leu Ser Ser Arg Leu Ile Thr Ser Asp Ser Thr Pro Ser Val 
     930                935                940
Ser Leu Val Met Lys Asp Cys Phe Pro Tyr Leu Glu Pro Leu Gly Thr 
 945                950                955                960
Ile Pro Asp Val Gln Lys Arg Met Leu Ala Ala Tyr Asp Leu Met Ile 
                 965                970                975
Gln Glu Ser Arg Val Leu Ile Glu Met Ala Asp Thr Val Gln Glu Lys 
             980                985                990
Ile Val Gln Cys Gln Lys Ala Gly Met Glu Phe His Glu Glu Leu His 
         995                1000                1005
Asn Leu Gly Ala Lys Glu Gly Leu Lys Gly Arg Lys Leu Asn Lys Ala 
     1010                1015                1020
Ile Glu Ser Phe Ala Trp Asn Ile Thr Val Leu Lys Gly Gln Gly Asp 
 1025                1030                1035                1040
Leu Leu Lys Asn Ala Lys Asn Glu Ala Val Glu Asn Ile Lys Gln Ile 
                 1045                1050                1055
Gln Leu Ala Cys Leu Ser Cys Gly Leu Ser Lys Gly Pro Gly Ser Ala 
             1060                1065                1070
Ala Glu Ala Lys Gly Lys Arg Ser Leu Glu Ala Ile Glu Glu Lys Glu 
         1075                1080                1085
Ser Ser Glu Glu Asn Gly Lys Leu 
     1090                1095



<210> 2077
<211> 4565
<212> DNA
<213> Homo sapiens
<308> D42108
<400> 2077

gaattccgg  cagcatcat  aaggcacat  gattctctc  ttgaacaat  cagctgctg  60
aggggatgg  gaagggatg  cactggcaa  tcaagactg  ctttcctac  tcttcagtg  120
ctctttcac  aatatgaag  taaaaccag  atccttcaa  ccaaaaatg  ggtggaaga  180
agaaaaccg  gtctttcag  agcatgcca  cggaaaaga  aattagcag  gcaaatgac  240
gcatcagct  catgcaagc  ggctgtgag  tgaagaaag  ccggccaaa  tctcgcatt  300
acaaccgtt  tttcactct  gacacagac  ttcaagctc  tcgctggga  ccttcaaag  360
aagacctcg  gaaagccaa  cttgatatt  ctgccataa  agagatcag  ctggggaaa  420
acacggaaa  atttacaaa  aatggcctt  ctgaccaga  ctgtgagga  tgtgccttt  480
ccatactcc  cggggaaaa  tatgagtct  tggacctag  tgccaattc  gcagatgtg  540
caaacatct  ggtgtctgg  ttacggtac  tggtttctc  aagtaagca  cctcttgat  600
ttatggagg  caaccagaa  acaccacgg  tcatgtggt  gaaaacagt  tttgaagca  660
cagatgttg  tgggaatgg  attatgttg  aagacacct  tgtagagtt  ataaaacaa  720
tcaacccta  tctgaagga  gccaagatc  ggttaaagt  taaagaaat  cagaagagc  780
aggaaaaac  aaccacccg  gtgaccgaa  aggaatttt  tgaagcttt  tgtgaactt  840
gcaccaggc  agaagtgta  ttcttactt  tacagatat  taaaaacaa  gaatatttg  900
atgccaatg  tctcatgct  tttttagaa  ctgagcaag  agtcaccca  atcaccgag  960
atatatgct  agacatcat  aggagatac  aactttctg  agagggacg  caaaaaggg  1020
ttcttgcaa  tgatggctt  acccagtat  tattgtcat  agaatgtga  atttttgat  1080
ctgagcaaa  gaaggttgc  caagatatg  cccagccat  atctcacta  tatatcaat  1140
cctctcata  cacctatct  atagaagac  agttcaggg  gccagctga  atcaatggg  1200
acattagag  tttgaaaat  ggctgtcga  gcgttgaac  cgatgtaag  gatggttca  1260
ataatgaac  aatcctttg  aatcgaaat  acatgacaa  ccatgtttc  tttcgaagt  1320
tcatagagg  aataaataa  tttgccttt  ttgcttctg  atacccact  attctttgc  1380
tgggaaatc  ctgctcctt  ccgcagcag  aggtaatgg  tcaacagat  aaaaaggtc  1440
ttggcaata  actctatac  gaagcacct  tgccctcag  atcctacct  ccatcacca  1500
aaaaattaa  aagaatgat  attgtgaaa  gaaagaagt  gccttctga  ccagatgtg  1560
tagaaggag  agtaacaga  gaagatgaa  aagctcaaa  gtctcgaag  atgtcggta  1620
attacaatg  tgagcagaa  caaatccga  tctgtaggg  gctctctga  ttggtgtct  1680
tttgtaaat  tgttcaata  agggatttt  aactatcta  gaaaagcca  aactattgg  1740
aaatgtgtt  atttagtga  acagaggcc  gccgcattg  aaatgagta  ccagaggat  1800
ttgttaatt  taataagaa  ttcttatca  gaatctatc  aagtgccat  aggatcgat  1860
ccagtaact  gaatccaca  gacttttgg  attgtggct  tcagattgt  gcaatgaat  1920
ttcagactc  gggtccaat  atggacctt  acacgggct  gtttcttca  aacggggga  1980
gtggttatg  tctaaggcc  tctataatg  gagatgaag  ttcttactt  agcgcaaat  2040
caaagggca  tctacctgg  gtgtctcct  tagctcttc  tatcaagat  atcagtggt  2100
agaatttcc  aaagcccaa  ggagcttgt  ccaaagggg  tgtcataga  ccctatgtt  2160
gtatagaga  acacggaat  ccagcggat  gttcggaac  aagaactaa  actgtacag  2220
aaaacagtg  taatcctat  tttgatgaa  cttttgagt  ccaagtaaa  ctacctgag  2280
tggccatga  ccgttttgt  gttctggat  atgactaca  tggggatga  tttataggg  2340
aatatacga  accatttga  tgtttgcag  ctggatatc  gcatgttcc  ctgcgttct  2400
ttgtgggtg  catcatgga  cacgtaacc  tttttgtcc  catagcaat  actaatcga  2460
gtggaggag  aaaggcaca  aagcgcagt  tttcagtga  aatggggaa  aaagttcgg  2520
aatatacca  gctcaggaa  atcggtctt  aaaccattg  tgacatctt  aaaatagcg  2580
ttcatccat  acgagaagc  atagatatg  gagaaaata  gcagaatgc  atcgtgtct  2640
ttaaggaac  atgtggact  cctccaatt  ccagtctga  gcagtgcct  ttaactctg  2700
catctcggc  catcaccag  gacaatact  cttcagtct  acttgtgat  aaagacagc  2760
ttccttacc  ggagcctct  ggtgcaatt  cagatgtgc  gaaaaagat  ctgactgct  2820
atgatctga  gattcaaga  agccggttt  tcatagaaa  ggcggacac  gtccaggaa  2880
agattgtac  gtgtcagaa  gcagggatg  agttccatg  agaacttca  aatttgggg  2940
caaaagaag  cttgaaggg  agaaaactc  acaaagcaa  tgagagctt  gcttggaac  3000
ttacagtat  gaagggcca  ggagatctg  tgaagaatg  caagaatga  gctatagaa  3060
acatgaagc  gatccagct  gcatgcctg  cctgtggac  gagtaaagc  cccagcagc  3120
gtgctgagg  caagagcaa  cgcagcctg  aagccatag  ggagaagga  agtagtgag  3180
agaatggga  gctgtgact  tgggcatta  cgacacgtt  acccatctt  tcaaggact  3240
tggtttctc  ttcttgttt  ctttcttta  atgttttat  agttcacaa  atggtgccc  3300
atatggggt  ttggacata  atattttca  aatgtcagt  tttcagtgt  gttaattta  3360
ctaaattaa  gcctttagt  tcagtgttt  aaattctga  acatgtgtc  acacccctg  3420
gtggatgcc  gtggaagag  gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtggc  3480
gagagagag  aagagagag  gagaaattc  gttaaaatc  attctgtgt  gcattattc  3540
tttagtgag  tattccttg  tcattttgg  acaattgtt  taatctgaa  ttctaaaga  3600
cacttactg  aacctgttg  tgtgtttaa  ttgacttct  tgcctttga  atttaattt  3660
gtgatctta  catagctta  tattgaagg  agccaaatt  atcaaagca  acatgtttt  3720
gtagattaa  tatagatta  aaaaattcc  aagaatcag  gtagaaata  aagtgaatg  3780
aagattaaa  agatgatga  aatttctaa  aagattagc  aggtcattt  ttcagtcag  3840
aaactttaa  aaatattta  taaataaaa  caattttta  gaagttttc  gtagtcatt  3900
actaaacat  tgatttcac  agaaaagct  atcataagt  aatttatac  tacctgtgt  3960
gctactctg  aacacactg  aagctctgt  gcaattagg  tttgatgtg  cataatatt  4020
ttgtataat  tcgagattt  taggaaggt  tcattcttc  aagctgaga  tctagcact  4080
attttctat  acagatatg  cagcttaga  gtgttggct  tgtttggat  taattttag  4140
ggtactaaa  tttaaaatt  aaagataat  gttcaacaa  atcatatca  cacattgag  4200
tgatataaa  tctgtgggt  cgataatat  tttgtgata  tttaagagc  aaccagtta  4260
cacacatct  tgatataac  ctaacacac  cagaaagca  acatgcaaa  agaaatgac  4320
aattagggt  catttataa  tgcatctag  taattttta  cctaatgtc  tcataaagt  4380
cttgagtgt  atgtttgtt  cctccaaca  aactaaatg  tctatggtt  tgaaagaat  4440
tatttattt  aagcattgc  tttattttg  aaagcttct  aattaattt  attaacaaa  4500
atgctaatt  ggggaaacc  agagaagat  attgttgaa  ttttgcaaa  ataaacatc  4560
cctat  4565



<210> 2078
<211> 997
<212> PRT
<213> Homo sapiens
<308> NP_006217
<400> 2078

Met Pro Ser Glu Lys Lys Ile Ser Ser Ala Asn Asp Cys Ile Ser Phe 
  1               5                  10                  15
Met Gln Ala Gly Cys Glu Leu Lys Lys Val Arg Pro Asn Ser Arg Ile 
             20                  25                  30
Tyr Asn Arg Phe Phe Thr Leu Asp Thr Asp Leu Gln Ala Leu Arg Trp 
         35                  40                  45
Glu Pro Ser Lys Lys Asp Leu Glu Lys Ala Lys Leu Asp Ile Ser Ala 
     50                  55                  60
Ile Lys Glu Ile Arg Leu Gly Lys Asn Thr Glu Thr Phe Thr Asn Asn 
 65                  70                  75                  80
Gly Leu Ala Asp Gln Ile Cys Glu Asp Cys Ala Phe Ser Ile Leu His 
                 85                  90                  95
Gly Glu Asn Tyr Glu Ser Leu Asp Leu Val Ala Asn Ser Ala Asp Val 
             100                105                110
Ala Asn Ile Trp Val Ser Gly Leu Arg Tyr Leu Val Ser Arg Ser Lys 
         115                120                125
Gln Pro Leu Asp Phe Met Glu Gly Asn Gln Asn Thr Pro Arg Phe Met 
     130                135                140
Trp Leu Lys Thr Val Phe Glu Ala Ala Asp Val Asp Gly Asn Gly Ile 
 145                150                155                160
Met Leu Glu Asp Thr Ser Val Glu Leu Ile Lys Gln Leu Asn Pro Thr 
                 165                170                175
Leu Lys Glu Ala Lys Ile Arg Leu Lys Phe Lys Glu Ile Gln Lys Ser 
             180                185                190
Lys Glu Lys Leu Thr Thr Arg Val Thr Glu Glu Glu Phe Cys Glu Ala 
         195                200                205
Phe Cys Glu Leu Cys Thr Arg Pro Glu Val Tyr Phe Leu Leu Val Gln 
     210                215                220
Ile Ser Lys Asn Lys Glu Tyr Leu Asp Ala Asn Asp Leu Met Leu Phe 
 225                230                235                240
Leu Glu Ala Glu Gln Gly Val Thr His Ile Thr Glu Asp Ile Cys Leu 
                 245                250                255
Asp Ile Ile Arg Arg Tyr Glu Leu Ser Glu Glu Gly Arg Gln Lys Gly 
             260                265                270
Phe Leu Ala Ile Asp Gly Phe Thr Gln Tyr Leu Leu Ser Ser Glu Cys 
         275                280                285
Asp Ile Phe Asp Pro Glu Gln Lys Lys Val Ala Gln Asp Met Thr Gln 
     290                295                300
Pro Leu Ser His Tyr Tyr Ile Asn Ala Ser His Asn Thr Tyr Leu Ile 
 305                310                315                320
Glu Asp Gln Phe Arg Gly Pro Ala Asp Ile Asn Gly Tyr Ile Arg Ala 
                 325                330                335
Leu Lys Met Gly Cys Arg Ser Val Glu Leu Asp Val Ser Asp Gly Ser 
             340                345                350
Asp Asn Glu Pro Ile Leu Cys Asn Arg Asn Asn Met Thr Thr His Val 
         355                360                365
Ser Phe Arg Ser Val Ile Glu Val Ile Asn Lys Phe Ala Phe Val Ala 
     370                375                380
Ser Glu Tyr Pro Leu Ile Leu Cys Leu Gly Asn His Cys Ser Leu Pro 
 385                390                395                400
Gln Gln Lys Val Met Ala Gln Gln Met Lys Lys Val Phe Gly Asn Lys 
                 405                410                415
Leu Tyr Thr Glu Ala Pro Leu Pro Ser Glu Ser Tyr Leu Pro Ser Pro 
             420                425                430
Glu Lys Leu Lys Arg Met Ile Ile Val Lys Gly Lys Lys Leu Pro Ser 
         435                440                445
Asp Pro Asp Val Leu Glu Gly Glu Val Thr Asp Glu Asp Glu Glu Ala 
     450                455                460
Gln Met Ser Arg Arg Met Ser Val Asp Tyr Asn Gly Glu Gln Lys Gln 
 465                470                475                480
Ile Arg Leu Cys Arg Glu Leu Ser Asp Leu Val Ser Ile Cys Lys Ser 
                 485                490                495
Val Gln Tyr Arg Asp Phe Glu Leu Ser Met Lys Ser Gln Asn Tyr Trp 
             500                505                510
Glu Met Cys Ser Phe Ser Glu Thr Glu Ala Ser Arg Ile Ala Asn Glu 
         515                520                525
Tyr Pro Glu Asp Phe Val Asn Tyr Asn Lys Lys Phe Leu Ser Arg Ile 
     530                535                540
Tyr Pro Ser Ala Met Arg Ile Asp Ser Ser Asn Leu Asn Pro Gln Asp 
 545                550                555                560
Phe Trp Asn Cys Gly Cys Gln Ile Val Ala Met Asn Phe Gln Thr Pro 
                 565                570                575
Gly Pro Met Met Asp Leu His Thr Gly Trp Phe Leu Gln Asn Gly Gly 
             580                585                590
Cys Gly Tyr Val Leu Arg Pro Ser Ile Met Arg Asp Glu Val Ser Tyr 
         595                600                605
Phe Ser Ala Asn Thr Lys Gly Ile Leu Pro Gly Val Ser Pro Leu Ala 
     610                615                620
Leu His Ile Lys Ile Ile Ser Gly Gln Asn Phe Pro Lys Pro Lys Gly 
 625                630                635                640
Ala Cys Ala Lys Gly Asp Val Ile Asp Pro Tyr Val Cys Ile Glu Ile 
                 645                650                655
His Gly Ile Pro Ala Asp Cys Ser Glu Gln Arg Thr Lys Thr Val Gln 
             660                665                670
Gln Asn Ser Asp Asn Pro Ile Phe Asp Glu Thr Phe Glu Phe Gln Val 
         675                680                685
Asn Leu Pro Glu Leu Ala Met Ile Arg Phe Val Val Leu Asp Asp Asp 
     690                695                700
Tyr Ile Gly Asp Glu Phe Ile Gly Gln Tyr Thr Ile Pro Phe Glu Cys 
 705                710                715                720
Leu Gln Pro Gly Tyr Arg His Val Pro Leu Arg Ser Phe Val Gly Asp 
                 725                730                735
Ile Met Glu His Val Thr Leu Phe Val His Ile Ala Ile Thr Asn Arg 
             740                745                750
Ser Gly Gly Gly Lys Ala Gln Lys Arg Ser Leu Ser Val Arg Met Gly 
         755                760                765
Lys Lys Val Arg Glu Tyr Thr Met Leu Arg Asn Ile Gly Leu Lys Thr 
     770                775                780
Ile Asp Asp Ile Phe Lys Ile Ala Val His Pro Leu Arg Glu Ala Ile 
 785                790                795                800
Asp Met Arg Glu Asn Met Gln Asn Ala Ile Val Ser Ile Lys Glu Leu 
                 805                810                815
Cys Gly Leu Pro Pro Ile Ala Ser Leu Lys Gln Cys Leu Leu Thr Leu 
             820                825                830
Ser Ser Arg Leu Ile Thr Ser Asp Asn Thr Pro Ser Val Ser Leu Val 
         835                840                845
Met Lys Asp Ser Phe Pro Tyr Leu Glu Pro Leu Gly Ala Ile Pro Asp 
     850                855                860
Val Gln Lys Lys Met Leu Thr Ala Tyr Asp Leu Met Ile Gln Glu Ser 
 865                870                875                880
Arg Phe Leu Ile Glu Met Ala Asp Thr Val Gln Glu Lys Ile Val Gln 
                 885                890                895
Cys Gln Lys Ala Gly Met Glu Phe His Glu Glu Leu His Asn Leu Gly 
             900                905                910
Ala Lys Glu Gly Leu Lys Gly Arg Lys Leu Asn Lys Ala Thr Glu Ser 
         915                920                925
Phe Ala Trp Asn Ile Thr Val Leu Lys Gly Gln Gly Asp Leu Leu Lys 
     930                935                940
Asn Ala Lys Asn Glu Ala Ile Glu Asn Met Lys Gln Ile Gln Leu Ala 
 945                950                955                960
Cys Leu Ser Cys Gly Leu Ser Lys Ala Pro Ser Ser Ser Ala Glu Ala 
                 965                970                975
Lys Ser Lys Arg Ser Leu Glu Ala Ile Glu Glu Lys Glu Ser Ser Glu 
             980                985                990
Glu Asn Gly Lys Leu 
         995



<210> 2079
<211> 5233
<212> DNA
<213> Rattus norvegicus
<308> D45920
<400> 2079

aggcagccg  cgccgcact  cctgaggcc  ccgctccgc  tcggcgggc  ggtggctgg  60
ggccggtcc  cagtcgccg  tcgggccgc  cgcgtccag  cttcggagg  ttcggaggc  120
ccgggctcc  gcgcccgct  tcttttgtc  gcgcagagc  ggcgctcgc  tcccctcgc  180
ggtacctcc  gctgctttt  gcctgcttc  ccctcccgc  cacatcttc  ccccgcccc  240
gccgccggt  cgcgccggc  gctgacctc  tggaccaca  cccgaggac  cctctgccc  300
agtgatgtc  cctctctac  aagttgcgg  cgccgctgc  gccgccgtc  cgcgctgaa  360
caaagtcta  cggcgtttc  ttctggtgc  tgagcgcac  cttactcag  gctggacgc  420
gctggcggt  gtgctgtct  gccgggagc  tagaacgtg  ttggccatg  ctgagggcg  480
ggctagcag  gaggctccg  cgcctctcg  cgttgcggg  ggcgaagac  accctcgag  540
cggcgccga  gctgcctcc  gggacgctg  acccgaggc  tcggggggc  ggatgaggg  600
ccgtcgcag  ggggttgcg  tgccgggca  tgcgggggt  cccgcggat  gcgaggctg  660
cctcctgga  gcggcacga  cgacccccc  gcgcacgag  atcatcaag  atccttcaa  720
ccaaaaatg  ggtggcaga  agaaaacag  gtctttcag  agcatgcca  cggagaaga  780
gattagcag  gcccatgac  gcattagct  catgcaggc  ggctgcgag  tgaagaaag  840
gcgaccgaa  tctcgcatc  acaaccgat  tttcaccct  gacactgac  tccaggctc  900
acgctggga  ccttccaag  aagacctcg  aaaagccaa  ctggacatt  ctgccatca  960
agagatcag  ctggggaag  acacggaga  attcagaaa  aatggcctt  ctgaccaga  1020
ctgtgaaga  tgtgccttc  ccatactcc  tggggaaaa  tacgagtct  tggacctag  1080
tgccaattc  gcagatgta  caaacatct  ggtgtcggg  ttacggtac  tggtctctc  1140
cagtaagca  ccacttgac  ttatggagg  caaccagaa  acaccacgg  tcatgtggc  1200
gaaaacggt  tttgaagca  cagatgttg  tgggaatgg  attatgtta  aagatacct  1260
ggtggagtt  ataaaacaa  tcaacccta  tctgaagga  tctaagatc  ggttaaagt  1320
taaagaaat  cagaagagc  aagaaaaac  aactacccg  gtaacagaa  aggaattct  1380
tgaagcgtt  tgtgaactt  gcactagac  agaagtgta  ttcttactt  ttcagatat  1440
taagaacaa  gagtatctg  atgctaatg  cctcatgct  tttttagaa  ttgagcaag  1500
ggtcaccca  gtcactgag  atatgtgct  agacatcat  aggagatac  aactttctg  1560
agatggccg  cagaaaggc  tccttgcaa  tgatggctt  acccagtat  tattatctc  1620
agaatgcga  atttttgat  cagagcaaa  gaaggttgc  caagacatg  cccaaccct  1680
atctcacta  tatatcaat  cgtcccata  tacctacct  atagaagat  agttcaggg  1740
gccagctga  atcaatggg  atgtgaggg  tttgaagat  ggctgtcga  gcattgagc  1800
tgatgtaag  gacggtcca  ataatgaac  catcctgtg  aataggaac  acatggcca  1860
gctcctttc  tttcgaagt  ttctggagg  gataaataa  ttcgccttc  tcgcttcag  1920
gtacccact  attctctgc  tggggaatc  ctgttccct  ccacagcag  gggtcatgg  1980
tcagcagat  aaaaaggtg  ttggcaata  actttatac  gaagcacct  tgtcttcag  2040
atcctacct  ccgtcgcct  aaaaactaa  acatatgat  attgtgaaa  gaaagaaat  2100
gccttcgga  tcagatctg  tagagggag  agtgaccga  gaggatgaa  aagctgaga  2160
gtcccggag  gtgtcggga  attacaacg  tgagcagaa  catatctgg  tctgccgag  2220
gctctctga  ttggtatcc  tctgtaaat  cgttcagta  agggatttt  aactgtcta  2280
gaaaaccca  aactactgg  aaatttgtt  atttagtga  acattggcc  gccggatcg  2340
aaatgagta  ccagaggat  tcgtgaatt  taacaagaa  ttcttatca  gggtctacc  2400
tagtgccat  aggatagat  ccagtaatt  gaacccaca  gacttctgg  attgtggct  2460
tcagattgt  gcaatgaat  ttcaaactc  tggtccaat  atggacctc  acaccggct  2520
gtttcttca  aatgggggc  gtggctacg  cctcaggcc  tctatcatg  gagatgaag  2580
ttcgtactt  agtgcaaac  caaagggca  tgtccctgg  gtgtctccc  tgcttcttc  2640
catcaagat  atcagtggt  agaacttcc  aaagcccaa  ggagcttgt  ccaaagggg  2700
tgtcataga  ccctacgtt  gtgtagaga  tcatggaat  ccagctgat  gctccgagc  2760
aagaactaa  actgtacaa  agaacagcg  taatcccat  ttcgatgaa  ctttcgagt  2820
tcaagtcaa  cttcccgag  tgaccatgg  ccgttttgt  attttggat  atgattaca  2880
tggagatga  ttcattggg  aatacacga  accgtttga  tgtctgcaa  ctgggtacc  2940
gcatgtccc  ttgcgctcc  ttgtggggg  tatcatgga  catgtgacc  tttttgtcc  3000
catagcaat  accaatcgg  gtggcggag  aaaagcgca  aagcgaagt  tttccgtga  3060
aatggggaa  aaagttcga  aatacacca  gctcagaaa  atcggtctt  aaaccatag  3120
tgatatctt  aaaatagca  ttcatcctt  gcgagaagc  atagatatg  gagaaaaca  3180
gcagaacgc  atagtgtct  ttaaggagc  gtgtggact  ccaccgatt  ccagtctga  3240
acagtgcct  ttaaccctg  cctctcgtc  catcaccag  gatagtact  cctccgtgt  3300
tctggtgat  aaggactgc  ttccttacc  ggagcctct  ggcacaatt  cagatgtgc  3360
gaagaggat  ctggctgca  atgatctga  gattcaaga  agtcgggtc  tcatagaaa  3420
ggctgacac  gtccaggaa  aaattgtac  gtgtcagaa  gcagggatg  aattccatg  3480
agaacttca  aatctaggg  caaaggaag  cttgaaggg  agaaaactc  acaaggcca  3540
cgagagctt  gcttggaat  ttactgtat  gaagggaca  ggagacctg  tgaagaatg  3600
caagaatga  gccgtagag  acataaagc  gatccagct  gcctgtttg  cttgtggac  3660
gagtaaagg  cctggcagc  ctgcagagg  caagggcaa  cgcagcttg  aagccatag  3720
ggagaagga  agcagtgaa  agaacggga  gttgtgagc  gggcagtgc  caggccctt  3780
tccaacact  tggtttctc  ttcttctcg  tttgttttg  ttttacatt  ttcagatgt  3840
cacagaaat  atgcccttt  cggggtgtt  tacataaac  tatattttc  cagtgtcag  3900
attttactg  agttaattt  tctaagtta  aacttttag  agcagtgtt  taaactttg  3960
gctgtgagt  tatacttac  tgtggctgc  tgtgtgtgt  tgtgtgtgt  tgtttgtgt  4020
tgtgtgtgt  tgtgtgtgt  tgtgtgtga  agagagaga  agagagaga  agagagaga  4080
agagagaga  agtaagagt  cctgttaaa  tattctctg  cgcattgtt  gttttaata  4140
gttattctt  tatctttaa  atcatttgg  gatagttga  aatctgaat  ctaatgagc  4200
tttattata  ccccttgct  tcgttagtt  tacctctct  cctttgtca  ataatttgg  4260
gatctcagc  cagcttatg  ttgaagaaa  ccaaattta  aagagcaaa  gcgttttat  4320
gattacata  agatttaaa  gttcctaaa  attacatta  aaatgaaag  gaatagaaa  4380
atcttttaa  atcataatt  tggaaagat  aacaaattc  tttcttcat  agcaaaatc  4440
ttgagatat  tattaacta  aatcacatt  aggaagttt  tgtagctgt  tactgagca  4500
gtggtttcg  tagaagagc  gagtgcaga  aacctgtag  cactgggca  tactttgaa  4560
cccactaaa  gctctactg  actagcact  ttgatgtga  cataacact  agttgtgca  4620
tttcaaggt  tgcagaaag  cctcattct  ctgggccgg  agtatggaa  tcattttct  4680
ttaccagtg  tgggcagat  caagtgctt  gccaggact  gatctagta  agattacta  4740
atttaagtg  caacacctt  ttaaaataa  atattatca  gttgagctg  cataaattc  4800
gtaagtccg  taacatctt  ctgatgatt  gagaactaa  taattagac  acatgtatg  4860
tataatttt  aaacataca  taaaaacca  gagcaagtg  ctaattagg  tacatttat  4920
attatatct  gataatctt  ccctaatgt  ttcataaac  tcttaaatg  catgttcat  4980
cattaccac  aacagaact  aatgttcta  gattatgaa  gaatatatt  gtttaaaac  5040
ttgctttta  tttgaaaag  ttcttaatt  atttgatta  caaatatat  aatttgggg  5100
agcctagag  agataatca  tgaaatttt  caaatataa  catcctcta  agctactat  5160
ttatttctg  ctgttctta  tactactct  ttcttgtcg  acattacca  aagagtaaa  5220
atactgaaa  cag  5233



<210> 2080
<211> 1096
<212> PRT
<213> Rattus norvegicus
<308> BAA08351
<400> 2080

Met Ala Glu Gly Ala Ala Ser Arg Glu Ala Pro Ala Pro Leu Asp Val 
  1               5                  10                  15
Ala Gly Gly Glu Asp Asp Pro Arg Ala Gly Ala Asp Ala Ala Ser Gly 
             20                  25                  30
Asp Ala Ala Pro Glu Ala Ser Gly Gly Arg Met Arg Asp Arg Arg Ser 
         35                  40                  45
Gly Val Ala Leu Pro Gly Asn Ala Gly Val Pro Ala Asp Ser Glu Ala 
     50                  55                  60
Gly Leu Leu Glu Ala Ala Arg Ala Thr Pro Arg Arg Thr Ser Ile Ile 
 65                  70                  75                  80
Lys Asp Pro Ser Asn Gln Lys Cys Gly Gly Arg Lys Lys Thr Val Ser 
                 85                  90                  95
Phe Ser Ser Met Pro Ser Glu Lys Lys Ile Ser Ser Ala His Asp Cys 
             100                105                110
Ile Ser Phe Met Gln Ala Gly Cys Glu Leu Lys Lys Val Arg Pro Asn 
         115                120                125
Ser Arg Ile Tyr Asn Arg Phe Phe Thr Leu Asp Thr Asp Leu Gln Ala 
     130                135                140
Leu Arg Trp Glu Pro Ser Lys Lys Asp Leu Glu Lys Ala Lys Leu Asp 
 145                150                155                160
Ile Ser Ala Ile Lys Glu Ile Arg Leu Gly Lys Asn Thr Glu Thr Phe 
                 165                170                175
Arg Asn Asn Gly Leu Ala Asp Gln Ile Cys Glu Asp Cys Ala Phe Ser 
             180                185                190
Ile Leu His Gly Glu Asn Tyr Glu Ser Leu Asp Leu Val Ala Asn Ser 
         195                200                205
Ala Asp Val Ala Asn Ile Trp Val Ser Gly Leu Arg Tyr Leu Val Ser 
     210                215                220
Arg Ser Lys Gln Pro Leu Asp Phe Met Glu Gly Asn Gln Asn Thr Pro 
 225                230                235                240
Arg Phe Met Trp Leu Lys Thr Val Phe Glu Ala Ala Asp Val Asp Gly 
                 245                250                255
Asn Gly Ile Met Leu Glu Asp Thr Ser Val Glu Leu Ile Lys Gln Leu 
             260                265                270
Asn Pro Thr Leu Lys Glu Ser Lys Ile Arg Leu Lys Phe Lys Glu Ile 
         275                280                285
Gln Lys Ser Lys Glu Lys Leu Thr Thr Arg Val Thr Glu Glu Glu Phe 
     290                295                300
Cys Glu Ala Phe Cys Glu Leu Cys Thr Arg Pro Glu Val Tyr Phe Leu 
 305                310                315                320
Leu Val Gln Ile Ser Lys Asn Lys Glu Tyr Leu Asp Ala Asn Asp Leu 
                 325                330                335
Met Leu Phe Leu Glu Val Glu Gln Gly Val Thr His Val Thr Glu Asp 
             340                345                350
Met Cys Leu Asp Ile Ile Arg Arg Tyr Glu Leu Ser Glu Asp Gly Arg 
         355                360                365
Gln Lys Gly Phe Leu Ala Ile Asp Gly Phe Thr Gln Tyr Leu Leu Ser 
     370                375                380
Pro Glu Cys Asp Ile Phe Asp Pro Glu Gln Lys Lys Val Ala Gln Asp 
 385                390                395                400
Met Thr Gln Pro Leu Ser His Tyr Tyr Ile Asn Ala Ser His Asn Thr 
                 405                410                415
Tyr Leu Ile Glu Asp Gln Phe Arg Gly Pro Ala Asp Ile Asn Gly Tyr 
             420                425                430
Val Arg Ala Leu Lys Met Gly Cys Arg Ser Ile Glu Leu Asp Val Ser 
         435                440                445
Asp Gly Pro Asp Asn Glu Pro Ile Leu Cys Asn Arg Asn Asn Met Ala 
     450                455                460
Met Leu Leu Ser Phe Arg Ser Val Leu Glu Val Ile Asn Lys Phe Ala 
 465                470                475                480
Phe Val Ala Ser Glu Tyr Pro Leu Ile Leu Cys Leu Gly Asn His Cys 
                 485                490                495
Ser Leu Pro Gln Gln Arg Val Met Val Gln Gln Met Lys Lys Val Phe 
             500                505                510
Gly Asn Lys Leu Tyr Thr Glu Ala Pro Leu Ser Ser Glu Ser Tyr Leu 
         515                520                525
Pro Ser Pro Glu Lys Leu Lys His Met Ile Ile Val Lys Gly Lys Lys 
     530                535                540
Leu Pro Ser Glu Ser Asp Leu Leu Glu Gly Glu Val Thr Asp Glu Asp 
 545                550                555                560
Glu Glu Ala Glu Met Ser Arg Arg Val Ser Gly Asp Tyr Asn Gly Glu 
                 565                570                575
Gln Lys His Ile Trp Leu Cys Arg Glu Leu Ser Asp Leu Val Ser Ile 
             580                585                590
Cys Lys Ser Val Gln Tyr Arg Asp Phe Glu Leu Ser Met Lys Thr Gln 
         595                600                605
Asn Tyr Trp Glu Ile Cys Ser Phe Ser Glu Thr Leu Ala Ser Arg Ile 
     610                615                620
Ala Asn Glu Tyr Pro Glu Asp Phe Val Asn Tyr Asn Lys Lys Phe Leu 
 625                630                635                640
Ser Arg Val Tyr Pro Ser Ala Met Arg Ile Asp Ser Ser Asn Leu Asn 
                 645                650                655
Pro Gln Asp Phe Trp Asn Cys Gly Cys Gln Ile Val Ala Met Asn Phe 
             660                665                670
Gln Thr Pro Gly Pro Met Met Asp Leu His Thr Gly Trp Phe Leu Gln 
         675                680                685
Asn Gly Gly Cys Gly Tyr Val Leu Arg Pro Ser Ile Met Arg Asp Glu 
     690                695                700
Val Ser Tyr Phe Ser Ala Asn Thr Lys Gly Ile Val Pro Gly Val Ser 
 705                710                715                720
Pro Leu Leu Leu His Ile Lys Ile Ile Ser Gly Gln Asn Phe Pro Lys 
                 725                730                735
Pro Lys Gly Ala Cys Ala Lys Gly Asp Val Ile Asp Pro Tyr Val Cys 
             740                745                750
Val Glu Ile His Gly Ile Pro Ala Asp Cys Ser Glu Gln Arg Thr Lys 
         755                760                765
Thr Val Gln Gln Asn Ser Asp Asn Pro Ile Phe Asp Glu Thr Phe Glu 
     770                775                780
Phe Gln Val Asn Leu Pro Glu Leu Thr Met Val Arg Phe Val Ile Leu 
 785                790                795                800
Asp Asp Asp Tyr Ile Gly Asp Glu Phe Ile Gly Gln Tyr Thr Ile Pro 
                 805                810                815
Phe Glu Cys Leu Gln Pro Gly Tyr Arg His Val Pro Leu Arg Ser Phe 
             820                825                830
Val Gly Asp Ile Met Glu His Val Thr Leu Phe Val His Ile Ala Ile 
         835                840                845
Thr Asn Arg Ser Gly Gly Gly Lys Ala Gln Lys Arg Ser Leu Ser Val 
     850                855                860
Arg Met Gly Lys Lys Val Arg Glu Tyr Thr Met Leu Arg Asn Ile Gly 
 865                870                875                880
Leu Lys Thr Ile Asp Asp Ile Phe Lys Ile Ala Val His Pro Leu Arg 
                 885                890                895
Glu Ala Ile Asp Met Arg Glu Asn Met Gln Asn Ala Ile Val Ser Val 
             900                905                910
Lys Glu Leu Cys Gly Leu Pro Pro Ile Ala Ser Leu Lys Gln Cys Leu 
         915                920                925
Leu Thr Leu Ser Ser Arg Leu Ile Thr Ser Asp Ser Thr Pro Ser Val 
     930                935                940
Ser Leu Val Met Lys Asp Cys Phe Pro Tyr Leu Glu Pro Leu Gly Thr 
 945                950                955                960
Ile Pro Asp Val Gln Lys Arg Met Leu Ala Ala Tyr Asp Leu Met Ile 
                 965                970                975
Gln Glu Ser Arg Val Leu Ile Glu Met Ala Asp Thr Val Gln Glu Lys 
             980                985                990
Ile Val Gln Cys Gln Lys Ala Gly Met Glu Phe His Glu Glu Leu His 
         995                1000                1005
Asn Leu Gly Ala Lys Glu Gly Leu Lys Gly Arg Lys Leu Asn Lys Ala 
     1010                1015                1020
Ile Glu Ser Phe Ala Trp Asn Ile Thr Val Leu Lys Gly Gln Gly Asp 
 1025                1030                1035                1040
Leu Leu Lys Asn Ala Lys Asn Glu Ala Val Glu Asn Ile Lys Gln Ile 
                 1045                1050                1055
Gln Leu Ala Cys Leu Ser Cys Gly Leu Ser Lys Gly Pro Gly Ser Ala 
             1060                1065                1070
Ala Glu Ala Lys Gly Lys Arg Ser Leu Glu Ala Ile Glu Glu Lys Glu 
         1075                1080                1085
Ser Ser Glu Glu Asn Gly Lys Leu 
     1090                1095



<210> 2081
<211> 4565
<212> DNA
<213> Homo sapiens
<308> D42108
<400> 2081

gaattccgg  cagcatcat  aaggcacat  gattctctc  ttgaacaat  cagctgctg  60
aggggatgg  gaagggatg  cactggcaa  tcaagactg  ctttcctac  tcttcagtg  120
ctctttcac  aatatgaag  taaaaccag  atccttcaa  ccaaaaatg  ggtggaaga  180
agaaaaccg  gtctttcag  agcatgcca  cggaaaaga  aattagcag  gcaaatgac  240
gcatcagct  catgcaagc  ggctgtgag  tgaagaaag  ccggccaaa  tctcgcatt  300
acaaccgtt  tttcactct  gacacagac  ttcaagctc  tcgctggga  ccttcaaag  360
aagacctcg  gaaagccaa  cttgatatt  ctgccataa  agagatcag  ctggggaaa  420
acacggaaa  atttacaaa  aatggcctt  ctgaccaga  ctgtgagga  tgtgccttt  480
ccatactcc  cggggaaaa  tatgagtct  tggacctag  tgccaattc  gcagatgtg  540
caaacatct  ggtgtctgg  ttacggtac  tggtttctc  aagtaagca  cctcttgat  600
ttatggagg  caaccagaa  acaccacgg  tcatgtggt  gaaaacagt  tttgaagca  660
cagatgttg  tgggaatgg  attatgttg  aagacacct  tgtagagtt  ataaaacaa  720
tcaacccta  tctgaagga  gccaagatc  ggttaaagt  taaagaaat  cagaagagc  780
aggaaaaac  aaccacccg  gtgaccgaa  aggaatttt  tgaagcttt  tgtgaactt  840
gcaccaggc  agaagtgta  ttcttactt  tacagatat  taaaaacaa  gaatatttg  900
atgccaatg  tctcatgct  tttttagaa  ctgagcaag  agtcaccca  atcaccgag  960
atatatgct  agacatcat  aggagatac  aactttctg  agagggacg  caaaaaggg  1020
ttcttgcaa  tgatggctt  acccagtat  tattgtcat  agaatgtga  atttttgat  1080
ctgagcaaa  gaaggttgc  caagatatg  cccagccat  atctcacta  tatatcaat  1140
cctctcata  cacctatct  atagaagac  agttcaggg  gccagctga  atcaatggg  1200
acattagag  tttgaaaat  ggctgtcga  gcgttgaac  cgatgtaag  gatggttca  1260
ataatgaac  aatcctttg  aatcgaaat  acatgacaa  ccatgtttc  tttcgaagt  1320
tcatagagg  aataaataa  tttgccttt  ttgcttctg  atacccact  attctttgc  1380
tgggaaatc  ctgctcctt  ccgcagcag  aggtaatgg  tcaacagat  aaaaaggtc  1440
ttggcaata  actctatac  gaagcacct  tgccctcag  atcctacct  ccatcacca  1500
aaaaattaa  aagaatgat  attgtgaaa  gaaagaagt  gccttctga  ccagatgtg  1560
tagaaggag  agtaacaga  gaagatgaa  aagctcaaa  gtctcgaag  atgtcggta  1620
attacaatg  tgagcagaa  caaatccga  tctgtaggg  gctctctga  ttggtgtct  1680
tttgtaaat  tgttcaata  agggatttt  aactatcta  gaaaagcca  aactattgg  1740
aaatgtgtt  atttagtga  acagaggcc  gccgcattg  aaatgagta  ccagaggat  1800
ttgttaatt  taataagaa  ttcttatca  gaatctatc  aagtgccat  aggatcgat  1860
ccagtaact  gaatccaca  gacttttgg  attgtggct  tcagattgt  gcaatgaat  1920
ttcagactc  gggtccaat  atggacctt  acacgggct  gtttcttca  aacggggga  1980
gtggttatg  tctaaggcc  tctataatg  gagatgaag  ttcttactt  agcgcaaat  2040
caaagggca  tctacctgg  gtgtctcct  tagctcttc  tatcaagat  atcagtggt  2100
agaatttcc  aaagcccaa  ggagcttgt  ccaaagggg  tgtcataga  ccctatgtt  2160
gtatagaga  acacggaat  ccagcggat  gttcggaac  aagaactaa  actgtacag  2220
aaaacagtg  taatcctat  tttgatgaa  cttttgagt  ccaagtaaa  ctacctgag  2280
tggccatga  ccgttttgt  gttctggat  atgactaca  tggggatga  tttataggg  2340
aatatacga  accatttga  tgtttgcag  ctggatatc  gcatgttcc  ctgcgttct  2400
ttgtgggtg  catcatgga  cacgtaacc  tttttgtcc  catagcaat  actaatcga  2460
gtggaggag  aaaggcaca  aagcgcagt  tttcagtga  aatggggaa  aaagttcgg  2520
aatatacca  gctcaggaa  atcggtctt  aaaccattg  tgacatctt  aaaatagcg  2580
ttcatccat  acgagaagc  atagatatg  gagaaaata  gcagaatgc  atcgtgtct  2640
ttaaggaac  atgtggact  cctccaatt  ccagtctga  gcagtgcct  ttaactctg  2700
catctcggc  catcaccag  gacaatact  cttcagtct  acttgtgat  aaagacagc  2760
ttccttacc  ggagcctct  ggtgcaatt  cagatgtgc  gaaaaagat  ctgactgct  2820
atgatctga  gattcaaga  agccggttt  tcatagaaa  ggcggacac  gtccaggaa  2880
agattgtac  gtgtcagaa  gcagggatg  agttccatg  agaacttca  aatttgggg  2940
caaaagaag  cttgaaggg  agaaaactc  acaaagcaa  tgagagctt  gcttggaac  3000
ttacagtat  gaagggcca  ggagatctg  tgaagaatg  caagaatga  gctatagaa  3060
acatgaagc  gatccagct  gcatgcctg  cctgtggac  gagtaaagc  cccagcagc  3120
gtgctgagg  caagagcaa  cgcagcctg  aagccatag  ggagaagga  agtagtgag  3180
agaatggga  gctgtgact  tgggcatta  cgacacgtt  acccatctt  tcaaggact  3240
tggtttctc  ttcttgttt  ctttcttta  atgttttat  agttcacaa  atggtgccc  3300
atatggggt  ttggacata  atattttca  aatgtcagt  tttcagtgt  gttaattta  3360
ctaaattaa  gcctttagt  tcagtgttt  aaattctga  acatgtgtc  acacccctg  3420
gtggatgcc  gtggaagag  gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtggc  3480
gagagagag  aagagagag  gagaaattc  gttaaaatc  attctgtgt  gcattattc  3540
tttagtgag  tattccttg  tcattttgg  acaattgtt  taatctgaa  ttctaaaga  3600
cacttactg  aacctgttg  tgtgtttaa  ttgacttct  tgcctttga  atttaattt  3660
gtgatctta  catagctta  tattgaagg  agccaaatt  atcaaagca  acatgtttt  3720
gtagattaa  tatagatta  aaaaattcc  aagaatcag  gtagaaata  aagtgaatg  3780
aagattaaa  agatgatga  aatttctaa  aagattagc  aggtcattt  ttcagtcag  3840
aaactttaa  aaatattta  taaataaaa  caattttta  gaagttttc  gtagtcatt  3900
actaaacat  tgatttcac  agaaaagct  atcataagt  aatttatac  tacctgtgt  3960
gctactctg  aacacactg  aagctctgt  gcaattagg  tttgatgtg  cataatatt  4020
ttgtataat  tcgagattt  taggaaggt  tcattcttc  aagctgaga  tctagcact  4080
attttctat  acagatatg  cagcttaga  gtgttggct  tgtttggat  taattttag  4140
ggtactaaa  tttaaaatt  aaagataat  gttcaacaa  atcatatca  cacattgag  4200
tgatataaa  tctgtgggt  cgataatat  tttgtgata  tttaagagc  aaccagtta  4260
cacacatct  tgatataac  ctaacacac  cagaaagca  acatgcaaa  agaaatgac  4320
aattagggt  catttataa  tgcatctag  taattttta  cctaatgtc  tcataaagt  4380
cttgagtgt  atgtttgtt  cctccaaca  aactaaatg  tctatggtt  tgaaagaat  4440
tatttattt  aagcattgc  tttattttg  aaagcttct  aattaattt  attaacaaa  4500
atgctaatt  ggggaaacc  agagaagat  attgttgaa  ttttgcaaa  ataaacatc  4560
cctat  4565



<210> 2082
<211> 997
<212> PRT
<213> Homo sapiens
<308> NP_006217
<400> 2082

Met Pro Ser Glu Lys Lys Ile Ser Ser Ala Asn Asp Cys Ile Ser Phe 
  1               5                  10                  15
Met Gln Ala Gly Cys Glu Leu Lys Lys Val Arg Pro Asn Ser Arg Ile 
             20                  25                  30
Tyr Asn Arg Phe Phe Thr Leu Asp Thr Asp Leu Gln Ala Leu Arg Trp 
         35                  40                  45
Glu Pro Ser Lys Lys Asp Leu Glu Lys Ala Lys Leu Asp Ile Ser Ala 
     50                  55                  60
Ile Lys Glu Ile Arg Leu Gly Lys Asn Thr Glu Thr Phe Thr Asn Asn 
 65                  70                  75                  80
Gly Leu Ala Asp Gln Ile Cys Glu Asp Cys Ala Phe Ser Ile Leu His 
                 85                  90                  95
Gly Glu Asn Tyr Glu Ser Leu Asp Leu Val Ala Asn Ser Ala Asp Val 
             100                105                110
Ala Asn Ile Trp Val Ser Gly Leu Arg Tyr Leu Val Ser Arg Ser Lys 
         115                120                125
Gln Pro Leu Asp Phe Met Glu Gly Asn Gln Asn Thr Pro Arg Phe Met 
     130                135                140
Trp Leu Lys Thr Val Phe Glu Ala Ala Asp Val Asp Gly Asn Gly Ile 
 145                150                155                160
Met Leu Glu Asp Thr Ser Val Glu Leu Ile Lys Gln Leu Asn Pro Thr 
                 165                170                175
Leu Lys Glu Ala Lys Ile Arg Leu Lys Phe Lys Glu Ile Gln Lys Ser 
             180                185                190
Lys Glu Lys Leu Thr Thr Arg Val Thr Glu Glu Glu Phe Cys Glu Ala 
         195                200                205
Phe Cys Glu Leu Cys Thr Arg Pro Glu Val Tyr Phe Leu Leu Val Gln 
     210                215                220
Ile Ser Lys Asn Lys Glu Tyr Leu Asp Ala Asn Asp Leu Met Leu Phe 
 225                230                235                240
Leu Glu Ala Glu Gln Gly Val Thr His Ile Thr Glu Asp Ile Cys Leu 
                 245                250                255
Asp Ile Ile Arg Arg Tyr Glu Leu Ser Glu Glu Gly Arg Gln Lys Gly 
             260                265                270
Phe Leu Ala Ile Asp Gly Phe Thr Gln Tyr Leu Leu Ser Ser Glu Cys 
         275                280                285
Asp Ile Phe Asp Pro Glu Gln Lys Lys Val Ala Gln Asp Met Thr Gln 
     290                295                300
Pro Leu Ser His Tyr Tyr Ile Asn Ala Ser His Asn Thr Tyr Leu Ile 
 305                310                315                320
Glu Asp Gln Phe Arg Gly Pro Ala Asp Ile Asn Gly Tyr Ile Arg Ala 
                 325                330                335
Leu Lys Met Gly Cys Arg Ser Val Glu Leu Asp Val Ser Asp Gly Ser 
             340                345                350
Asp Asn Glu Pro Ile Leu Cys Asn Arg Asn Asn Met Thr Thr His Val 
         355                360                365
Ser Phe Arg Ser Val Ile Glu Val Ile Asn Lys Phe Ala Phe Val Ala 
     370                375                380
Ser Glu Tyr Pro Leu Ile Leu Cys Leu Gly Asn His Cys Ser Leu Pro 
 385                390                395                400
Gln Gln Lys Val Met Ala Gln Gln Met Lys Lys Val Phe Gly Asn Lys 
                 405                410                415
Leu Tyr Thr Glu Ala Pro Leu Pro Ser Glu Ser Tyr Leu Pro Ser Pro 
             420                425                430
Glu Lys Leu Lys Arg Met Ile Ile Val Lys Gly Lys Lys Leu Pro Ser 
         435                440                445
Asp Pro Asp Val Leu Glu Gly Glu Val Thr Asp Glu Asp Glu Glu Ala 
     450                455                460
Gln Met Ser Arg Arg Met Ser Val Asp Tyr Asn Gly Glu Gln Lys Gln 
 465                470                475                480
Ile Arg Leu Cys Arg Glu Leu Ser Asp Leu Val Ser Ile Cys Lys Ser 
                 485                490                495
Val Gln Tyr Arg Asp Phe Glu Leu Ser Met Lys Ser Gln Asn Tyr Trp 
             500                505                510
Glu Met Cys Ser Phe Ser Glu Thr Glu Ala Ser Arg Ile Ala Asn Glu 
         515                520                525
Tyr Pro Glu Asp Phe Val Asn Tyr Asn Lys Lys Phe Leu Ser Arg Ile 
     530                535                540
Tyr Pro Ser Ala Met Arg Ile Asp Ser Ser Asn Leu Asn Pro Gln Asp 
 545                550                555                560
Phe Trp Asn Cys Gly Cys Gln Ile Val Ala Met Asn Phe Gln Thr Pro 
                 565                570                575
Gly Pro Met Met Asp Leu His Thr Gly Trp Phe Leu Gln Asn Gly Gly 
             580                585                590
Cys Gly Tyr Val Leu Arg Pro Ser Ile Met Arg Asp Glu Val Ser Tyr 
         595                600                605
Phe Ser Ala Asn Thr Lys Gly Ile Leu Pro Gly Val Ser Pro Leu Ala 
     610                615                620
Leu His Ile Lys Ile Ile Ser Gly Gln Asn Phe Pro Lys Pro Lys Gly 
 625                630                635                640
Ala Cys Ala Lys Gly Asp Val Ile Asp Pro Tyr Val Cys Ile Glu Ile 
                 645                650                655
His Gly Ile Pro Ala Asp Cys Ser Glu Gln Arg Thr Lys Thr Val Gln 
             660                665                670
Gln Asn Ser Asp Asn Pro Ile Phe Asp Glu Thr Phe Glu Phe Gln Val 
         675                680                685
Asn Leu Pro Glu Leu Ala Met Ile Arg Phe Val Val Leu Asp Asp Asp 
     690                695                700
Tyr Ile Gly Asp Glu Phe Ile Gly Gln Tyr Thr Ile Pro Phe Glu Cys 
 705                710                715                720
Leu Gln Pro Gly Tyr Arg His Val Pro Leu Arg Ser Phe Val Gly Asp 
                 725                730                735
Ile Met Glu His Val Thr Leu Phe Val His Ile Ala Ile Thr Asn Arg 
             740                745                750
Ser Gly Gly Gly Lys Ala Gln Lys Arg Ser Leu Ser Val Arg Met Gly 
         755                760                765
Lys Lys Val Arg Glu Tyr Thr Met Leu Arg Asn Ile Gly Leu Lys Thr 
     770                775                780
Ile Asp Asp Ile Phe Lys Ile Ala Val His Pro Leu Arg Glu Ala Ile 
 785                790                795                800
Asp Met Arg Glu Asn Met Gln Asn Ala Ile Val Ser Ile Lys Glu Leu 
                 805                810                815
Cys Gly Leu Pro Pro Ile Ala Ser Leu Lys Gln Cys Leu Leu Thr Leu 
             820                825                830
Ser Ser Arg Leu Ile Thr Ser Asp Asn Thr Pro Ser Val Ser Leu Val 
         835                840                845
Met Lys Asp Ser Phe Pro Tyr Leu Glu Pro Leu Gly Ala Ile Pro Asp 
     850                855                860
Val Gln Lys Lys Met Leu Thr Ala Tyr Asp Leu Met Ile Gln Glu Ser 
 865                870                875                880
Arg Phe Leu Ile Glu Met Ala Asp Thr Val Gln Glu Lys Ile Val Gln 
                 885                890                895
Cys Gln Lys Ala Gly Met Glu Phe His Glu Glu Leu His Asn Leu Gly 
             900                905                910
Ala Lys Glu Gly Leu Lys Gly Arg Lys Leu Asn Lys Ala Thr Glu Ser 
         915                920                925
Phe Ala Trp Asn Ile Thr Val Leu Lys Gly Gln Gly Asp Leu Leu Lys 
     930                935                940
Asn Ala Lys Asn Glu Ala Ile Glu Asn Met Lys Gln Ile Gln Leu Ala 
 945                950                955                960
Cys Leu Ser Cys Gly Leu Ser Lys Ala Pro Ser Ser Ser Ala Glu Ala 
                 965                970                975
Lys Ser Lys Arg Ser Leu Glu Ala Ile Glu Glu Lys Glu Ser Ser Glu 
             980                985                990
Glu Asn Gly Lys Leu 
         995



<210> 2083
<211> 869
<212> DNA
<213> Rattus norvegicus
<308> D49363
<400> 2083

cgggatcct  cagagggaa  gattagcat  tcgtcaata  tcagaaaag  gatcagcac  60
tcaaaagcc  cggcggcca  tggtgccta  agccaagct  tgctagtgg  caggaccat  120
tacgtttct  gacagatag  catggatcc  tccagtgga  aacttgtgc  aggaggggt  180
gcagaagaa  ctaaacaag  tcttaaaaa  ctgggtgag  ttctgaagg  tgcagggtg  240
gacttcact  atgtggtga  gacaactgt  ttactggct  acataaatg  ctttggcac  300
gtcaatgag  tctacaaaa  atatttcca  ggtaacctt  ctgccaggg  tgcttacca  360
gtcgccgct  tacccaaag  aagtcgaat  gaaatcgaa  ccatcgctg  ccaggggcc  420
ttcaccaca  caggactgt  aggagccat  ctgatgctg  ctctggagt  tttacaatg  480
ctctcacac  ttaaatttt  caaatgatt  tgggaatgc  cacatgagc  gtgtgaagt  540
atcgtggaa  tgatcatac  tgtggagat  tgacattaa  tggggatta  tcagtacag  600
ggctagtgc  gtaatttca  ttatgtggc  gggtgtgag  gaaaggcac  tagctgcta  660
catgcagag  agaatcaaa  acgaaacag  aaagagcac  cctaattaa  tcatatcaa  720
ttgcttgtg  ggaatactt  gttctcatg  tagatatca  aaactaaat  aaaatattc  780
aactttaat  gtaccagga  aaaaaagtg  accaaaatc  tataagata  tactgcctt  840
atggaataa  aaacagatg  gtaactttc  869



<210> 2084
<211> 136
<212> PRT
<213> Rattus norvegicus
<308> BAA08359
<400> 2084

Ser Ser Ile Ile Arg Lys Val Ile Ser Thr Ser Lys Ala Pro Ala Ala 
  1               5                  10                  15
Ile Gly Ala Tyr Ser Gln Ala Val Leu Val Asp Arg Thr Ile Tyr Val 
             20                  25                  30
Ser Gly Gln Ile Gly Met Asp Pro Ser Ser Gly Gln Leu Val Pro Gly 
         35                  40                  45
Gly Val Ala Glu Glu Ala Lys Gln Ala Leu Lys Asn Leu Gly Glu Ile 
     50                  55                  60
Leu Lys Ala Ala Gly Cys Asp Phe Thr Asn Val Val Lys Thr Thr Val 
 65                  70                  75                  80
Leu Leu Ala Asp Ile Asn Asp Phe Gly Thr Val Asn Glu Ile Tyr Lys 
                 85                  90                  95
Thr Tyr Phe Gln Gly Asn Leu Pro Ala Arg Ala Ala Tyr Gln Val Ala 
             100                105                110
Ala Leu Pro Lys Gly Ser Arg Ile Glu Ile Glu Ala Ile Ala Val Gln 
         115                120                125
Gly Pro Phe Thr Thr Ala Gly Leu 
     130                135



<210> 2085
<211> 5956
<212> DNA
<213> Homo sapiens
<308> AY026764
<400> 2085

ggcgctgct  tggttggtc  gtccagtaa  aagccagca  ggctggtgc  ggggcttct  60
ctcctgaag  ggctgcaag  gggaaggct  agccatgtc  tccttgatc  gaagggtga  120
cagcaccgc  aaagcccca  gggccattg  accctacag  caagctgta  tagtcgaca  180
gaccattta  atttcagga  agataggca  ggacccttc  agtggacag  ttgtgtcag  240
aggggtagc  gaagaagct  aacaagtaa  ttattttcc  catttaagg  cccttttct  300
ctacctttt  aatgttgaa  agcattaag  atccacttg  ctgatttgt  ttatagaga  360
taacagata  atgtttttt  aactactta  tgcttgatt  aacatagtt  ttgatctaa  420
agttggaaa  ttgatggat  atgaatcat  taacaacca  aagagagat  ccacctcct  480
aacactaag  tgaccttaa  cctgaatta  tgacgtcag  tgacatgtt  ccacttcca  540
atggattgg  aaattttct  ctcagggcc  ctgacctgc  cctcttcaa  aaaaaaaaa  600
attaccacc  cagaagtaa  aagtcaaca  ttttaaaaa  aagaatggg  aatataatt  660
taatccaat  aatataatt  aaccataat  taggccagg  acgatgtgg  tcacacctg  720
aatcctagc  ctttgggag  ccgaggctg  cagttcact  gaggtcagg  gttcaagac  780
agcctagac  acatggtga  accccatct  tactaaaaa  acaaaaatt  gtgggggga  840
gccaggcac  atggctcac  cctgtaatc  cagcacttt  ggaggccga  gcgggcaga  900
cacctgagg  caggagttc  agaccagcc  ggccaacat  gtgaaaccc  gtctctact  960
aaaatacaa  aattagcag  tgtggtggc  tgtgcctgt  gtcccagct  ctcgggagg  1020
taaggcatg  gaatcgttt  aacccggaa  gcggaggtt  cagtgagct  agattgtgc  1080
actccactc  agcctgggc  acagagcaa  aaccctgtc  caaaaaaaa  aatagaaaa  1140
aaaaagtaa  ccagtcagg  ggcacatgc  tgtagtccc  gttactcag  aggcgtatg  1200
agaagaatc  cttaaacct  ggaggtgga  gttgcagga  gccaagatc  tgccactgc  1260
ctcctgcct  ggacacaga  taagacact  tctcaaaaa  taaaataaa  taaaacaat  1320
aactataat  tactgcatt  actgagtca  ataatgctg  aagtttgtt  tgttttgtt  1380
tgtttcttg  gacagcctt  ctctgtcgc  caggctgga  tgcagtgtc  tgatctcag  1440
tcactgcaa  ctctgtctt  caggttcaa  caattctct  gcctcagcc  cccaagtaa  1500
tgggactac  ggcacacgc  accacacct  gcttatttt  tgtattttt  gtagagacg  1560
ggttttacc  tgctagcca  gatggtctc  atctcctga  ctcatgatc  acccacctc  1620
gcctcccaa  gtgctgaga  tacaggcat  agcctccac  cccggccta  ctgaaagat  1680
tttaaaaac  taaatatcc  ctcataaag  actggttga  taaattatg  tagatcaat  1740
caactaaag  aatgtggaa  gatctccga  gtaaattgt  ccatggtaa  aaaaccaag  1800
tgcagaaca  catgcacag  atgctacca  gtgtgcttg  gtgtttaaa  atatgtaac  1860
taagcattg  ctgtaccta  aaggatata  aataaatta  gaacagtgg  tacctctga  1920
gagggaaac  tgggagagg  agagagggg  gatagatat  tttacacgg  atatgcttt  1980
ttaatagct  ttgagtttt  ttgttgttg  tgttgccat  tccatgtat  acctattta  2040
aagattatt  taaaagaca  aaggaatat  atgaaatat  gcattgtga  cagcaaagt  2100
ggaagagtg  atccaaaaa  agataaatg  ttttccaga  gccagtgtc  ccaactgtt  2160
tataattta  taatattgt  tttttgaga  aaaggaaaa  gaacccttt  aagtcaaat  2220
ttgctttaa  agaaaatat  ttttaatgc  tactagctc  tccttatcc  tgacgtgat  2280
tcgaatgaa  aacaccaga  attatttct  tggacattg  ctgaacaat  aacacattt  2340
agcactgaa  aaggaactt  aacctagtc  ttttacgca  aaaaggaga  aacattttc  2400
ccatatttc  gaaagactc  ttctattaa  ggaaagcca  gaaacacac  tgtaagcga  2460
tagggagga  ttttctgca  cataagcta  ttaaggagg  attagtaaa  gatgattaa  2520
tgaatttaa  taaagcttt  aatctaaca  cagtgactt  ggcctttct  ggcttggtt  2580
accaggctc  taaaaacat  ggtgaaatt  tgaaagctg  aggctgtga  ttcactaac  2640
gtgagcaat  tgatattat  tcacatttc  ttttgatat  tctttggtc  ttttgaaaa  2700
tatatggca  ccagtaaga  gccgtgcca  atctttgtt  ctatttaaa  gttgtttta  2760
atagcaact  ttctacttc  cttctttgg  cccatttca  tcccatttt  atcaagaca  2820
tctcagatt  atacactct  tttctaagt  atgttttgg  tcagaccaa  taactaaac  2880
taatgacaa  gtttatatc  tctagtggt  aaaacaact  ttcttctgg  tgacataaa  2940
gacttcaat  ctgtcaatg  aatctacaa  cagtgtaag  aatttggct  tattcctat  3000
ttccatttt  aaaaagaaa  aaatctggt  acattaatg  atgtgcatt  tgaatttag  3060
gtggtagga  atgctaaag  aatggtcat  gatcttaaa  gaattaata  tctgattgg  3120
aatatgttg  atacccccc  tgaaaaagt  ctaagacat  tctattgca  tccctaaaa  3180
aatatactg  aaycctaca  atccatttt  caaaagctt  atttcatta  atccttctc  3240
ggcttttta  actctccta  caagttttt  atgcataga  tttatttac  gtggctgta  3300
ggtgcagcc  ccatcttta  cctggctct  tcagactca  tagttagtt  cttaatatt  3360
ctatgcctt  gttttctca  atgcaaaat  gagataata  actcctaac  tatagggtt  3420
ttggaatga  taaatgagt  agtacaaca  gtaaagcac  tagatgctg  tgtgttata  3480
gcactgagt  aatgttagc  attattaac  ttgatgtta  agtagggaa  attggtgtc  3540
caacaccta  tgggatgag  caaaggtat  acttggaaa  agcatcgtt  cttattctc  3600
cctgaagaa  ttattagaa  agaccaaag  tggcagagg  agtacttgc  aaaatttct  3660
gagatgggc  cttgttcct  tttagataa  tagtttata  atatcactt  aaaaacaaa  3720
ctccattca  atcaaacaa  atcaaaatg  tagggtatg  attyctttt  ttttttttt  3780
ttttttgcc  gaaagctaa  agattttaa  aagtattaa  tatcatagg  atcatatgg  3840
aaaatattt  atcaaacaa  tctgatagt  agcctcttt  ttaaaatgt  gcttaaggc  3900
aggagcagt  gctcacacc  ataatccca  cactttgag  ggctgaggt  ggtggatca  3960
ttgacatta  gagtttgag  ccagtctgg  caacatggt  aagccccga  tctactaaa  4020
atacaaaaa  gagccaggc  tggtggtgc  cacctgtaa  cccagctac  cgggaggct  4080
aggcaggag  atctcttga  catgggaga  agaggttgc  gtaagctga  atcgcatca  4140
ttcactcca  ccttgggcg  tagagcaag  ctctgtttc  aaaaaataa  aataaatgt  4200
gcttatatc  aagaactga  tagtatatg  aatatttgc  agattatta  ttgtagata  4260
tgaataaca  tagaatatc  gaaaactaa  ataaaaatt  tcacttgat  tttattttt  4320
caactcttc  ctattaaaa  aatgaaatt  ttttaaatt  agatttcaa  agtaatttt  4380
ctgctagag  tgcttacca  gttgctgct  tacccaaag  aagtacact  taaatgact  4440
atgtacaca  ttttcagtt  ctacattgt  ttccttcta  aagtaaact  agcactgtg  4500
aaggaaact  aaaagaagt  gcctgggca  ggtggctta  ccctgtaat  ccagtgctt  4560
gaaaggcca  cacaggagg  tcgcttgag  ccaggagtt  tagaccagc  tgggcaaca  4620
agcaagaca  ccatcccta  aaaaacaat  taaaattag  catgcatgg  ggtggtgca  4680
acctatagt  ccagctact  ggtaggctg  ggtgggagg  acacttgaa  ccaggagtt  4740
aaggctgca  tgagctata  tcgaaccac  gtgctgcag  ctgggtaac  gtgtgacct  4800
gtctcttaa  aaaaaaaaa  aaagaaaag  aatagaccc  gcttcccca  ggaacttaa  4860
gtctgaaag  aaatatccc  tattacatg  atgaaaaaa  aattaagaa  ccttttaag  4920
cagcacatg  acagagaat  agaatcaaa  tacttaaat  gtgagaaaa  gccaggcgc  4980
gtggcktca  gcctgtaat  ccagcgctt  cggaggccg  ggcgggcgg  tcacaaggt  5040
agaagatcg  gaccatcct  gctcacatg  tgaaacccg  ctctactaa  aatacaaaa  5100
aaaattagc  gggtgtggt  gcggacgcc  gtagtccca  ctactcggg  ggctgaggc  5160
ggagaatgg  atgaaccca  gaggcagag  ttgcagtga  ccgaaatcg  gccactgca  5220
tccagcctg  gcgacagag  gagactcca  cacaaaaaa  aaaaaattg  gagaaaaaa  5280
aaaatagca  ctgtactgt  gtagtgtta  ttaggggac  ataaatttg  gccaggttt  5340
tttgtgagt  ctgcagtaa  aatttcacc  ggatattgt  caattaaaa  tctaagcct  5400
ccactagaa  aataatctc  aaaccaggg  cacacatat  tctcaccat  ttgattttg  5460
tacttttaa  tcaagctta  cagcacaat  ttcctgcct  taaaaaagc  gctcttact  5520
acttccact  gcagtttct  ctaaagaaa  tttatgttt  aagagtgtc  tttgtattg  5580
tttaattag  tgttacttg  aatgatcat  atcaaacct  ttaaggtac  ggggtgtag  5640
agaaagagc  ctgaacttg  aatcacaag  caagggttc  acctctgct  tctagttgt  5700
acttgggat  acttaatta  tccttctac  cttcagcat  tcattctgt  aattgaggg  5760
aaaatacgt  tctaatagg  cttctgtga  aatcacata  gctaatata  tatatgaat  5820
tacctagca  ggtaacctg  tctgcaatt  gtacaaaat  attacaaca  attctttca  5880
tttcctcac  gggcagccg  attgaaatt  aagcagtag  tatccaagg  ccactgaca  5940
cggcatcac  ataagt  5956



<210> 2086
<211> 137
<212> PRT
<213> Homo sapiens
<308> AAK01939
<400> 2086

Met Ser Ser Leu Ile Arg Arg Val Ile Ser Thr Ala Lys Ala Pro Gly 
  1               5                  10                  15
Ala Ile Gly Pro Tyr Ser Gln Ala Val Leu Val Asp Arg Thr Ile Tyr 
             20                  25                  30
Ile Ser Gly Gln Ile Gly Met Asp Pro Ser Ser Gly Gln Leu Val Ser 
         35                  40                  45
Gly Gly Val Ala Glu Glu Ala Lys Gln Ala Leu Lys Asn Met Gly Glu 
     50                  55                  60
Ile Leu Lys Ala Ala Gly Cys Asp Phe Thr Asn Val Val Lys Thr Thr 
 65                  70                  75                  80
Val Leu Leu Ala Asp Ile Asn Asp Phe Asn Thr Val Asn Glu Ile Tyr 
                 85                  90                  95
Lys Gln Tyr Phe Lys Ser Asn Phe Pro Ala Arg Ala Ala Tyr Gln Val 
             100                105                110
Ala Ala Leu Pro Lys Gly Ser Arg Ile Glu Ile Glu Ala Val Ala Ile 
         115                120                125
Gln Gly Pro Leu Thr Thr Ala Ser Leu 
     130                135



<210> 2087
<211> 1475
<212> DNA
<213> Rattus norvegicus
<308> D49395
<400> 2087

atgccgctc  gcatcccgc  ggtgctgtt  gccttgttc  tttccgtgc  gatagccca  60
ggagaaggc  gccggagga  ggccaccca  gcccacagc  ccacccagc  tgctctgct  120
aggctgtca  atcacctcc  ggctaacta  aagaaggga  tgcggcctg  gcgggactg  180
aggaagccc  ccctggtct  cattgatgt  atcatgtat  ccatcctca  cgtggatga  240
aagaaccag  ttctgacca  ctacatatg  taccggcag  tctggaccg  cgagtttct  300
cagtggact  ctgaggact  cgacaatgt  accaaattg  ccatcccca  cgacagcat  360
tgggtccct  acatcctca  caatgagtt  gtggacgtg  ggaagtctc  aagcattcc  420
tatgtgtat  tgcaccatc  aggtgaagt  cagaactac  agcccctac  gctggtgac  480
gcctgtagc  ttgacatct  taacttccc  ttcgatgtg  agaactgct  tctgacctt  540
accagctgg  tgcatacca  ccaggacat  aacatttcc  tgtggcgaa  accagaaga  600
gtgaggtcg  acaagagca  cttcataaa  cagggcgag  gggagctgc  gggggtgtt  660
accaaattt  aggagttca  tatagaaac  agtaacagc  atgcggaaa  gaagttcta  720
gtggtcatc  gccggcggc  tttattcta  gcagtcagc  tcttgctgc  cagtatctt  780
ctcatggtc  tggacattg  gggcttttg  ctgcccccg  acagtggtg  gagagtgtc  840
ttcaagatc  cgctccttc  gggatactc  gtctttctc  tcatcgtgt  agacacact  900
cctgcaacg  ccatcggca  tcccctcat  ggtgtctac  ttgtagtgt  catggctct  960
ctggtgata  gcctcgctg  gaccatctt  attgtgcag  tggtgcata  gcaggattt  1020
cagcgccct  tacctgact  gctgaggca  ctggtccta  acagaatag  ctggctgct  1080
tgcctaggg  agcagccca  ggcccatag  cccccagcc  ccttccaag  caacaagac  1140
gatgactgc  cagccatgg  aaaccactg  agccatgtc  gaagccctc  ggacttgga  1200
aagacctcg  ggagcagag  tagccctct  ccaccacca  gggaggcct  gctggctgt  1260
cgtggcctc  tgcaagagc  gtcctccat  cgccactcc  tggagaagc  ggatgagat  1320
cgggaggtg  caagggact  gttgcgggt  ggatatgtg  tggacaggc  gctgtttcg  1380
atctacctg  tggccgtgc  ggcttacag  atcaccctg  tcacgctct  gtccatttg  1440
cattattcc  gagtgggta  agcctggca  ggagg  1475



<210> 2088
<211> 483
<212> PRT
<213> Rattus norvegicus
<308> BAA08388
<400> 2088

Met Pro Leu Cys Ile Pro Gln Val Leu Leu Ala Leu Phe Leu Ser Val 
  1               5                  10                  15
Leu Ile Ala Gln Gly Glu Gly Ser Arg Arg Arg Ala Thr Gln Ala His 
             20                  25                  30
Ser Thr Thr Gln Pro Ala Leu Leu Arg Leu Ser Asp His Leu Leu Ala 
         35                  40                  45
Asn Tyr Lys Lys Gly Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr 
     50                  55                  60
Leu Val Ser Ile Asp Val Ile Met Tyr Ala Ile Leu Asn Val Asp Glu 
 65                  70                  75                  80
Lys Asn Gln Val Leu Thr Thr Tyr Ile Trp Tyr Arg Gln Phe Trp Thr 
                 85                  90                  95
Asp Glu Phe Leu Gln Trp Thr Pro Glu Asp Phe Asp Asn Val Thr Lys 
             100                105                110
Leu Ser Ile Pro Thr Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn 
         115                120                125
Glu Phe Val Asp Val Gly Lys Ser Pro Ser Ile Pro Tyr Val Tyr Val 
     130                135                140
His His Gln Gly Glu Val Gln Asn Tyr Lys Pro Leu Gln Leu Val Thr 
 145                150                155                160
Ala Cys Ser Leu Asp Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys 
                 165                170                175
Ser Leu Thr Phe Thr Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile 
             180                185                190
Ser Leu Trp Arg Thr Pro Glu Glu Val Arg Ser Asp Lys Ser Ile Phe 
         195                200                205
Ile Asn Gln Gly Glu Trp Glu Leu Leu Gly Val Phe Thr Lys Phe Gln 
     210                215                220
Glu Phe Ser Ile Glu Thr Ser Asn Ser Tyr Ala Glu Met Lys Phe Tyr 
 225                230                235                240
Val Val Ile Arg Arg Arg Pro Leu Phe Tyr Ala Val Ser Leu Leu Leu 
                 245                250                255
Pro Ser Ile Phe Leu Met Val Val Asp Ile Val Gly Phe Cys Leu Pro 
             260                265                270
Pro Asp Ser Gly Glu Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly 
         275                280                285
Tyr Ser Val Phe Leu Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala 
     290                295                300
Ile Gly Thr Pro Leu Ile Gly Val Tyr Phe Val Val Cys Met Ala Leu 
 305                310                315                320
Leu Val Ile Ser Leu Ala Glu Thr Ile Phe Ile Val Gln Leu Val His 
                 325                330                335
Lys Gln Asp Leu Gln Arg Pro Val Pro Asp Trp Leu Arg His Leu Val 
             340                345                350
Leu Asp Arg Ile Ala Trp Leu Leu Cys Leu Gly Glu Gln Pro Met Ala 
         355                360                365
His Arg Pro Pro Ala Thr Phe Gln Ala Asn Lys Thr Asp Asp Cys Ser 
     370                375                380
Ala Met Gly Asn His Cys Ser His Val Gly Ser Pro Gln Asp Leu Glu 
 385                390                395                400
Lys Thr Ser Arg Ser Arg Asp Ser Pro Leu Pro Pro Pro Arg Glu Ala 
                 405                410                415
Ser Leu Ala Val Arg Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg His 
             420                425                430
Ser Leu Glu Lys Arg Asp Glu Met Arg Glu Val Ala Arg Asp Trp Leu 
         435                440                445
Arg Val Gly Tyr Val Leu Asp Arg Leu Leu Phe Arg Ile Tyr Leu Leu 
     450                455                460
Ala Val Leu Ala Tyr Ser Ile Thr Leu Val Thr Leu Trp Ser Ile Trp 
 465                470                475                480
His Tyr Ser 
                 485



<210> 2089
<211> 2202
<212> DNA
<213> Homo sapiens
<308> NM_000869
<400> 2089

ggaaacatg  tccagctga  ggactgatt  caggaaaac  tggcagctc  ccaaccttg  60
tggcccagg  agtgtgagg  tgcagcctc  gaaggtgtg  gcagtggcc  cgagaggca  120
gctggctgg  acatgaggt  ggcagaggg  aggcaagct  gcccttggt  ggcctcgcc  180
tgagcactc  gaggcactc  tatgcttgg  aagctcgct  tgctgctgt  ggtccagca  240
gcgctgctc  ccttgctcc  ccccacact  ctggcacag  gagaagcca  gaggagccg  300
aacaccacc  ggcccgctc  gctgaggct  tcggattac  ttttgacca  ctacaggaa  360
ggtgtgcgc  ccgtgaggg  ctggaggaa  ccaaccacc  tatccattg  cgtcattgt  420
tatgccatc  tcaacgtgg  tgagaagaa  caggtgctg  ccacctaca  ctggtaccg  480
cagtactgg  ctgatgagt  tctccagtg  aaccctgag  actttgaca  catcaccaa  540
ttgtccatc  ccacggaca  catctgggt  ccggacatt  tcatcaatg  gttcgtgga  600
gtggggaag  ctccaaata  cccgtacgt  tatattcgg  atcaaggcg  agttcagaa  660
tacaagccc  ttcaggtgg  gactgcctg  agcctcgac  tctacaact  ccccttcga  720
gtccagaac  gctcgctga  cttcaccag  tggctgcac  ccatccagg  catcaacat  780
tctttgtgg  gcttgccag  aaaggtgaa  tccgacagg  gtgtcttca  gaaccaggg  840
gagtgggag  tgctggggg  gctgcccta  tttcgggag  tcagcatgg  aagcagtaa  900
tactatgca  aaatgaagt  ctatgtggt  atccgccgg  ggcccctct  ctatgtggt  960
agcctgcta  tgcccagca  cttcctcat  gtcatggac  tcgtgggct  ctacctgcc  1020
cccaacagt  gcgagaggg  ctctttcaa  attacactc  tcctgggct  ctcggtctt  1080
ctgatcatc  tttctgaca  gctgccggc  actgccatc  gcactcctc  cattggtgt  1140
tactttgtg  tgtgcatgg  tctgctggt  ataagtttg  ccgagacca  cttcattgt  1200
cggctggtg  acaagcaag  cctgcagca  cccgtgcct  cttggctgc  tcacctggt  1260
ctggagaga  tcgcctggc  actttgcct  agggagcag  caacttccc  gaggccccc  1320
gccacctcc  aagccacca  gactgatga  tgctcagcc  tgggaaacc  ctgcagcca  1380
atgggagga  cccaggact  cgagaagag  ccgagggac  gatgtagcc  tcccccacc  1440
cctcgggag  cctcgctgg  ggtgtgtgg  ctgctgcag  agctgtcct  catccggca  1500
ttcctggaa  agcgggatg  gatccgaga  gtggcccga  actggctgc  cgtgggctc  1560
gtgctggac  agctgctat  ccacattta  ctgctagcg  tgctggcct  cagcatcac  1620
ctggttatg  tctggtcca  ctggcagta  gcttgagtg  gtacagccc  gtggaggag  1680
gggtacagt  ctggttagg  ggggacaga  gatttctgc  taggcccct  aggacccag  1740
gaatgccag  gacattttc  agacacaga  aaagtcccg  gccctgttt  caatgccaa  1800
tcatctcag  aatcacaag  caaggtctg  acccttcca  caaaaactg  gtgttcaag  1860
cccttacac  cttgtccca  ccccagcag  tcaccatgg  tttaaaaca  gctctctta  1920
atcaggaga  actcgggca  tccctaagt  cactctagt  gtggacttt  ccccattga  1980
cctcacctg  ataagggac  ttggaattc  gcttctctt  cacaacttt  cttttaggt  2040
gaaggcaaa  ccaactctc  actacacag  cctgataac  ctgtacgag  cttctctaa  2100
ccctagtgt  ttttttttc  tcacctcac  tgtggcagc  tccctgaac  ctcatcccc  2160
atcagatga  gggagtggg  agaataaaa  gcagtgaaa  cc  2202



<210> 2090
<211> 478
<212> PRT
<213> Homo sapiens
<308> P46098
<400> 2090

Met Leu Leu Trp Val Gln Gln Ala Leu Leu Ala Leu Leu Leu Pro Thr 
  1               5                  10                  15
Leu Leu Ala Gln Gly Glu Ala Arg Arg Ser Arg Asn Thr Thr Arg Pro 
             20                  25                  30
Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu Thr Asn Tyr Arg Lys Gly 
         35                  40                  45
Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr Thr Val Ser Ile Asp 
     50                  55                  60
Val Ile Val Tyr Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val Leu 
 65                  70                  75                  80
Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp Thr Asp Glu Phe Leu Gln 
                 85                  90                  95
Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr Lys Leu Ser Ile Pro Thr 
             100                105                110
Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn Glu Phe Val Asp Val 
         115                120                125
Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr Ile Arg His Gln Gly Glu 
     130                135                140
Val Gln Asn Tyr Lys Pro Leu Gln Val Val Thr Ala Cys Ser Leu Asp 
 145                150                155                160
Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Thr 
                 165                170                175
Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile Ser Leu Trp Arg Leu 
             180                185                190
Pro Glu Lys Val Lys Ser Asp Arg Ser Val Phe Met Asn Gln Gly Glu 
         195                200                205
Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe Arg Glu Phe Ser Met Glu 
     210                215                220
Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe Tyr Val Val Ile Arg Arg 
 225                230                235                240
Arg Pro Leu Phe Tyr Val Val Ser Leu Leu Leu Pro Ser Ile Phe Leu 
                 245                250                255
Met Val Met Asp Ile Val Gly Phe Tyr Leu Pro Pro Asn Ser Gly Glu 
             260                265                270
Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly Tyr Ser Val Phe Leu 
         275                280                285
Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala Ile Gly Thr Pro Leu 
     290                295                300
Ile Gly Val Tyr Phe Val Val Cys Met Ala Leu Leu Val Ile Ser Leu 
 305                310                315                320
Ala Glu Thr Ile Phe Ile Val Arg Leu Val His Lys Gln Asp Leu Gln 
                 325                330                335
Gln Pro Val Pro Ala Trp Leu Arg His Leu Val Leu Glu Arg Ile Ala 
             340                345                350
Trp Leu Leu Cys Leu Arg Glu Gln Ser Thr Ser Gln Arg Pro Pro Ala 
         355                360                365
Thr Ser Gln Ala Thr Lys Thr Asp Asp Cys Ser Ala Met Gly Asn His 
     370                375                380
Cys Ser His Met Gly Gly Pro Gln Asp Phe Glu Lys Ser Pro Arg Asp 
 385                390                395                400
Arg Cys Ser Pro Pro Pro Pro Pro Arg Glu Ala Ser Leu Ala Val Cys 
                 405                410                415
Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg Gln Phe Leu Glu Lys Arg 
             420                425                430
Asp Glu Ile Arg Glu Val Ala Arg Asp Trp Leu Arg Val Gly Ser Val 
         435                440                445
Leu Asp Lys Leu Leu Phe His Ile Tyr Leu Leu Ala Val Leu Ala Tyr 
     450                455                460
Ser Ile Thr Leu Val Met Leu Trp Ser Ile Trp Gln Tyr Ala 
 465                470                475



<210> 2091
<211> 2251
<212> DNA
<213> Rattus norvegicus
<308> D49446
<400> 2091

cgcagcgga  ctccatctc  ccaccctgg  gtgacatcc  tccagggac  ggagctgga  60
ctccagcat  gctgaggag  agaaactga  actcagcaa  accgtgttg  cctccgagt  120
tatgaaggt  gtggcagaa  ccatgggca  tgctcagat  caggaggag  cttgccagc  180
actgacaga  gaggtcagc  accgcatca  ggagattgc  caggatgct  tgaagttca  240
gcacatggg  aaacgacag  agctcacta  cagtgacat  gactatgca  tgaaattaa  300
gaatgtgga  ccactatat  gcttccatg  tcaggagtt  atccctttc  ggtttgcct  360
tggtggggg  cgggagctg  acttctatg  agagaagga  gtggacctg  gtgatatca  420
caacacccc  ctgcctcgg  tgcctctgg  tgtctgcct  aaagctcat  ggctgagca  480
tgaaggctg  cagccagct  taccagaga  tccaccccc  gctcccaaa  agcagcaga  540
ggccgaggc  acagaaccc  tgaagtcag  aaagccagg  caagaagaa  atggaccct  600
gaaaggcaa  ggtcaaggg  cagctgcag  tgatggcaa  ggaaaagag  agaaggcac  660
tcccttgct  gagggggcc  ctttccgcc  gaagccccg  agcatccat  agctgtccg  720
ggagcagca  ctgtactac  aggagatca  agaagcctg  gtgggatcc  gtgaggcca  780
gagagcgga  gctctgcag  gcattgcca  agatcctgg  ctctatcag  tgttaccac  840
gtttagtac  ttcatctca  agggggtcc  tgtgaatgt  gttcagaat  acctggcct  900
gctcatcta  ttgatgcga  tggttaagg  cctgatgga  aaccccaca  tgtatcttg  960
gaaatatgt  cacgagctg  ttcctgcag  aatgacctg  attgtgagc  gacagctgt  1020
cctgcggcc  gatgtggac  atcactggg  actccggga  tttgctgcc  gtctagtgg  1080
ccagatctg  aagcatttc  gcacaacca  caacaacat  caatcccga  tcaccaaga  1140
ctttaccaa  agctgggtg  atgagaaga  tccatggac  actcgatat  gctccattg  1200
aggcctggc  gagctgggg  atgatgtga  taagaccct  attctgcca  ggctgcagc  1260
ggaagggga  cggatccga  gtgtcttgg  cggacctgt  ctaagcaac  tcgaccgta  1320
cggagcaga  catgttcag  gccttctcc  gaaacactg  gccccagta  tggcgaagc  1380
gcgccctcc  cctgacaat  aggatgcct  ccggggaga  tttgggtcc  ttgggcccc  1440
tctctgctc  catgtggtg  aggccaggg  ccaggccgc  cttcaagct  agcaggtca  1500
caggaccac  ctcaccatc  cacagcctc  gcccacact  accctctca  aggcccctc  1560
gccaggccc  cgtacccct  gcttattga  ggtccctgg  tctattgcc  tgcctgtcc  1620
gacactggt  tctgcaaga  ctgctgccc  tcctcagcc  tctcctcct  caaccaagt  1680
tattgtaat  tcctcatct  ccagtgcct  atcaaccca  caggtcctg  ccctcagca  1740
ctcagctcc  ggttcaggc  ctaccacta  ctctcctgt  accaccaca  ttcccagcg  1800
gcagcccat  gtcaagctg  tctccactg  taccactgc  cccccaagc  cagcccctg  1860
tggtcctgg  agtgttcag  aatacattg  ggtctctct  cccccaaca  gggaaggca  1920
aggaggccc  ccttctcat  cttctccag  cccaccttc  tcttcttca  catctccac  1980
tgggggcag  gccctctgt  gggggaagc  ggaaactgg  gacagcccc  ctccagctc  2040
agggactcc  aaggctaat  gctcccagc  tactggacc  agctctccc  agcctgctc  2100
gtgatattg  cacatgtgc  gacctcctc  cttctgcag  ttcctacac  cacaaacaa  2160
gtgtgaggg  ggaagaaga  agatgtttt  cccagtgac  ttcttttta  atactgtac  2220
gtaagttcc  cagaataaa  gttggattt  t  2251



<210> 2092
<211> 678
<212> PRT
<213> Rattus norvegicus
<308> BAA08435
<400> 2092

Met Ala Glu Glu Lys Lys Leu Lys Leu Ser Asn Thr Val Leu Pro Ser 
  1               5                  10                  15
Glu Ser Met Lys Val Val Ala Glu Ser Met Gly Ile Ala Gln Ile Gln 
             20                  25                  30
Glu Glu Thr Cys Gln Leu Leu Thr Asp Glu Val Ser Tyr Arg Ile Lys 
         35                  40                  45
Glu Ile Ala Gln Asp Ala Leu Lys Phe Met His Met Gly Lys Arg Gln 
     50                  55                  60
Lys Leu Thr Thr Ser Asp Ile Asp Tyr Ala Leu Lys Leu Lys Asn Val 
 65                  70                  75                  80
Glu Pro Leu Tyr Gly Phe His Ala Gln Glu Phe Ile Pro Phe Arg Phe 
                 85                  90                  95
Ala Ser Gly Gly Gly Arg Glu Leu Tyr Phe Tyr Glu Glu Lys Glu Val 
             100                105                110
Asp Leu Ser Asp Ile Ile Asn Thr Pro Leu Pro Arg Val Pro Leu Asp 
         115                120                125
Val Cys Leu Lys Ala His Trp Leu Ser Ile Glu Gly Cys Gln Pro Ala 
     130                135                140
Ile Pro Glu Asn Pro Pro Pro Ala Pro Lys Glu Gln Gln Lys Ala Glu 
 145                150                155                160
Ala Thr Glu Pro Leu Lys Ser Ala Lys Pro Gly Gln Glu Glu Asp Gly 
                 165                170                175
Pro Leu Lys Gly Lys Gly Gln Gly Ala Ala Ala Ala Asp Gly Lys Gly 
             180                185                190
Lys Glu Lys Lys Ala Pro Pro Leu Leu Glu Gly Ala Pro Phe Arg Leu 
         195                200                205
Lys Pro Arg Ser Ile His Glu Leu Ser Val Glu Gln Gln Leu Tyr Tyr 
     210                215                220
Lys Glu Ile Thr Glu Ala Cys Val Gly Ser Cys Glu Ala Lys Arg Ala 
 225                230                235                240
Glu Ala Leu Gln Ser Ile Ala Thr Asp Pro Gly Leu Tyr Gln Met Leu 
                 245                250                255
Pro Arg Phe Ser Thr Phe Ile Ser Glu Gly Val Arg Val Asn Val Val 
             260                265                270
Gln Asn Asn Leu Ala Leu Leu Ile Tyr Leu Met Arg Met Val Lys Ala 
         275                280                285
Leu Met Asp Asn Pro Thr Leu Tyr Leu Glu Lys Tyr Val His Glu Leu 
     290                295                300
Ile Pro Ala Val Met Thr Cys Ile Val Ser Arg Gln Leu Cys Leu Arg 
 305                310                315                320
Pro Asp Val Asp Asn His Trp Ala Leu Arg Asp Phe Ala Ala Arg Leu 
                 325                330                335
Val Ala Gln Ile Cys Lys His Phe Ser Thr Thr Thr Asn Asn Ile Gln 
             340                345                350
Ser Arg Ile Thr Lys Thr Phe Thr Lys Ser Trp Val Asp Glu Lys Thr 
         355                360                365
Pro Trp Thr Thr Arg Tyr Gly Ser Ile Ala Gly Leu Ala Glu Leu Gly 
     370                375                380
His Asp Val Ile Lys Thr Leu Ile Leu Pro Arg Leu Gln Gln Glu Gly 
 385                390                395                400
Glu Arg Ile Arg Ser Val Leu Asp Gly Pro Val Leu Ser Asn Ile Asp 
                 405                410                415
Arg Ile Gly Ala Asp His Val Gln Ser Leu Leu Leu Lys His Cys Ala 
             420                425                430
Pro Val Leu Ala Lys Leu Arg Pro Pro Pro Asp Asn Gln Asp Ala Tyr 
         435                440                445
Arg Gly Glu Phe Gly Ser Leu Gly Pro Leu Leu Cys Ser His Val Val 
     450                455                460
Lys Ala Arg Ala Gln Ala Ala Leu Gln Ala Gln Gln Val Asn Arg Thr 
 465                470                475                480
Thr Leu Thr Ile Thr Gln Pro Arg Pro Thr Leu Thr Leu Ser Gln Ala 
                 485                490                495
Pro Gln Pro Gly Pro Arg Thr Pro Gly Leu Leu Lys Val Pro Gly Ser 
             500                505                510
Ile Ala Leu Pro Val Gln Thr Leu Val Ser Ala Arg Ala Ala Ala Pro 
         515                520                525
Pro Gln Pro Ser Pro Pro Pro Thr Lys Phe Ile Val Met Ser Ser Ser 
     530                535                540
Ser Ser Ala Ser Ser Thr Gln Gln Val Leu Ser Leu Ser Thr Ser Ala 
 545                550                555                560
Pro Gly Ser Gly Ser Thr Thr Thr Ser Pro Val Thr Thr Thr Val Pro 
                 565                570                575
Ser Val Gln Pro Ile Val Lys Leu Val Ser Thr Ala Thr Thr Ala Pro 
             580                585                590
Pro Ser Thr Ala Pro Ala Gly Pro Gly Ser Val Gln Lys Tyr Ile Val 
         595                600                605
Val Ser Leu Pro Pro Thr Gly Glu Gly Lys Gly Gly Pro Pro Ser His 
     610                615                620
Pro Ser Pro Val Pro Pro Ser Ser Ser Ser Pro Ser Pro Leu Gly Gly 
 625                630                635                640
Ser Ala Leu Cys Gly Gly Lys Gln Glu Thr Gly Asp Ser Pro Pro Pro 
                 645                650                655
Ala Pro Gly Thr Pro Lys Ala Asn Gly Ser Gln Pro Thr Gly Pro Ser 
             660                665                670
Ser Pro Gln Pro Ala Leu 
         675



<210> 2093
<211> 2510
<212> DNA
<213> Homo sapiens
<308> U31659
<400> 2093

gaattcctg  cctcaagtg  tccgcccgc  tcgtcctcc  aaggtgctg  tgggattac  60
ggcgtgagc  actgaacct  gccccagcc  agatttgta  ctttctctg  tacacctca  120
ggctgactc  cgtggggat  gacataaga  actcggagt  cctcccctg  ctccactgt  180
ctccctttg  tggccctct  cctgtgtct  acgtttctt  ttcttctgc  tgccccgtt  240
ctctgccag  gtctccgtc  ctccaccgg  ggcttcatc  ttccaggga  gagaagagg  300
actccagaa  ggctgagga  aagaagctg  agcttagca  cactgtgct  ccctcggag  360
ccatgaagg  ggtggctga  tccatgggc  tcgcccaga  tcaggagga  acctgccag  420
tgctaacgg  tgaggtcag  taccgcatc  aagagatcg  acaggatgc  ttgaagttc  480
tgcacatgg  gaagcggca  aagctcacc  ccagtgaca  tgactacgc  ttgaagcta  540
agaatgtcg  gccactcta  ggcttccac  cccaggagt  cattccttt  cgcttcgcc  600
ctggtgggg  ccgggagct  tacttctat  aggagaagg  ggttgatct  agcgacatc  660
tcaataccc  tctgccccg  gtgcccctg  acgtctgcc  caaagctca  tggctgagc  720
tcgagggct  ccagccagc  atccccgag  acccgcccc  agctcccaa  gagcaacag  780
aggctgaag  cacagaacc  ctgaagtca  ccaagccag  ccaggagga  gacggaccc  840
tgaagggca  aggtcaagg  gccaccaca  ccgacggca  agggaaaga  aagaaggcg  900
cgcccttgc  ggagggggc  cccttgcga  tgaagcccc  gagcatcca  gagttgtct  960
tggagcagc  gctctacta  aaggagatc  ccgaggcct  cgtgggctc  tgcgaggcc  1020
agagggcgg  agccctgca  agcattgcc  cggaccctg  actgtatca  atgctgcca  1080
ggttcagta  ctttatctc  gagggggtc  gtgtgaacg  ggttcagaa  aacctggcc  1140
tactcatct  cctgatgcg  atggtgaaa  cgctgatgg  caaccccac  ctctatcta  1200
aaaaatacg  ccatgagct  attccagct  tgatgacct  catcgtgag  agacagttg  1260
gcctgcgac  agatgtgga  aatcactgg  cactccgag  ctttgctgc  cgcctggtg  1320
cccagatct  caagcattt  agcacaacc  ctaacaaca  ccagtcccg  atcaccaag  1380
ccttcacca  gagctgggt  gacgagaag  cgccctgga  gactcgtta  ggctccatc  1440
caggcttgg  tgagctggg  cacgatgtt  tcaagactc  gattctgcc  cggctgcag  1500
aggaagggg  gcggatccg  agtgtgctg  acggccctg  gctgagcaa  attgaccgg  1560
ttggagcag  ccatgtgca  agcctcctg  tgaaacact  tgctcctgt  ctggcaaag  1620
tgcgcccac  gcctgacaa  caggacgcc  atcgggcag  attcgggtc  cttgggccc  1680
tcctctgct  ccaggtggt  aaggctcgg  cccaggctg  tctgcaggc  cagcaggtc  1740
acaggacca  tctgaccat  acgcagccc  ggcccacgc  gaccctctc  caggcccca  1800
agcctggcc  tcgcacccc  ggcttgctg  aggttcctg  ctccatcgc  cttcctgtc  1860
agacactgg  gtctgcacg  gcggctgcc  caccacagc  ttcccctcc  ccaaccaag  1920
ttattgtaa  gtcatcgtc  tccagcgcc  catccaccc  gcaggtcct  tccctcagc  1980
cctcggccc  cggctcagg  tccaccacc  cttcgcccg  caccaccac  gtccccagc  2040
tgcagccca  cgtcaagtt  gtctccacc  ccaccaccg  accccccag  actgctccc  2100
ctggtcctg  gagtgtcca  aagtacatc  tggtctcac  tcccccaac  ggggagggc  2160
aaggaggcc  cacctccca  ccttctcca  ttcctcccc  ggcatcgtc  ccgtcccca  2220
tcagcggca  tgccctttg  ggggggaag  aggaggctg  ggacagtcc  cctccagct  2280
cagggactc  aaaagccaa  ggctcccag  ccaactccg  ctcccctca  cctgctccg  2340
gatgctcca  ctgccagcc  ccggattcc  acacatgca  acatgtaca  acgtgcacg  2400
acacacatg  atgctcgct  agcggaagg  agttgtaga  tgcttcctt  atgtcactt  2460
ctttttaga  attgtacag  cagtttctc  gaataaaag  ttggtttgta  2510



<210> 2094
<211> 677
<212> PRT
<213> Homo sapiens
<308> P49848
<400> 2094

Met Ala Glu Glu Lys Lys Leu Lys Leu Ser Asn Thr Val Leu Pro Ser 
  1               5                  10                  15
Glu Ser Met Lys Val Val Ala Glu Ser Met Gly Ile Ala Gln Ile Gln 
             20                  25                  30
Glu Glu Thr Cys Gln Leu Leu Thr Asp Glu Val Ser Tyr Arg Ile Lys 
         35                  40                  45
Glu Ile Ala Gln Asp Ala Leu Lys Phe Met His Met Gly Lys Arg Gln 
     50                  55                  60
Lys Leu Thr Thr Ser Asp Ile Asp Tyr Ala Leu Lys Leu Lys Asn Val 
 65                  70                  75                  80
Glu Pro Leu Tyr Gly Phe His Ala Gln Glu Phe Ile Pro Phe Arg Phe 
                 85                  90                  95
Ala Ser Gly Gly Gly Arg Glu Leu Tyr Phe Tyr Glu Glu Lys Glu Val 
             100                105                110
Asp Leu Ser Asp Ile Ile Asn Thr Pro Leu Pro Arg Val Pro Leu Asp 
         115                120                125
Val Cys Leu Lys Ala His Trp Leu Ser Ile Glu Gly Cys Gln Pro Ala 
     130                135                140
Ile Pro Glu Asn Pro Pro Pro Ala Pro Lys Glu Gln Gln Lys Ala Glu 
 145                150                155                160
Ala Thr Glu Pro Leu Lys Ser Ala Lys Pro Gly Gln Glu Glu Asp Gly 
                 165                170                175
Pro Leu Lys Gly Lys Gly Gln Gly Ala Thr Thr Ala Asp Gly Lys Gly 
             180                185                190
Lys Glu Lys Lys Ala Pro Pro Leu Leu Glu Gly Ala Pro Leu Arg Leu 
         195                200                205
Lys Pro Arg Ser Ile His Glu Leu Ser Val Glu Gln Gln Leu Tyr Tyr 
     210                215                220
Lys Glu Ile Thr Glu Ala Cys Val Gly Ser Cys Glu Ala Lys Arg Ala 
 225                230                235                240
Glu Ala Leu Gln Ser Ile Ala Thr Asp Pro Gly Leu Tyr Gln Met Leu 
                 245                250                255
Pro Arg Phe Ser Thr Phe Ile Ser Glu Gly Val Arg Val Asn Val Val 
             260                265                270
Gln Asn Asn Leu Ala Leu Leu Ile Tyr Leu Met Arg Met Val Lys Ala 
         275                280                285
Leu Met Asp Asn Pro Thr Leu Tyr Leu Glu Lys Tyr Val His Glu Leu 
     290                295                300
Ile Pro Ala Val Met Thr Cys Ile Val Ser Arg Gln Leu Cys Leu Arg 
 305                310                315                320
Pro Asp Val Asp Asn His Trp Ala Leu Arg Asp Phe Ala Ala Arg Leu 
                 325                330                335
Val Ala Gln Ile Cys Lys His Phe Ser Thr Thr Thr Asn Asn Ile Gln 
             340                345                350
Ser Arg Ile Thr Lys Thr Phe Thr Lys Ser Trp Val Asp Glu Lys Thr 
         355                360                365
Pro Trp Thr Thr Arg Tyr Gly Ser Ile Ala Gly Leu Ala Glu Leu Gly 
     370                375                380
His Asp Val Ile Lys Thr Leu Ile Leu Pro Arg Leu Gln Gln Glu Gly 
 385                390                395                400
Glu Arg Ile Arg Ser Val Leu Asp Gly Pro Val Leu Ser Asn Ile Asp 
                 405                410                415
Arg Ile Gly Ala Asp His Val Gln Ser Leu Leu Leu Lys His Cys Ala 
             420                425                430
Pro Val Leu Ala Lys Leu Arg Pro Pro Pro Asp Asn Gln Asp Ala Tyr 
         435                440                445
Arg Ala Glu Phe Gly Ser Leu Gly Pro Leu Leu Cys Ser Gln Val Val 
     450                455                460
Lys Ala Arg Ala Gln Ala Ala Leu Gln Ala Gln Gln Val Asn Arg Thr 
 465                470                475                480
Thr Leu Thr Ile Thr Gln Pro Arg Pro Thr Leu Thr Leu Ser Gln Ala 
                 485                490                495
Pro Gln Pro Gly Pro Arg Thr Pro Gly Leu Leu Lys Val Pro Gly Ser 
             500                505                510
Ile Ala Leu Pro Val Gln Thr Leu Val Ser Ala Arg Ala Ala Ala Pro 
         515                520                525
Pro Gln Pro Ser Pro Pro Pro Thr Lys Phe Ile Val Met Ser Ser Ser 
     530                535                540
Ser Ser Ala Pro Ser Thr Gln Gln Val Leu Ser Leu Ser Thr Ser Ala 
 545                550                555                560
Pro Gly Ser Gly Ser Thr Thr Thr Ser Pro Val Thr Thr Thr Val Pro 
                 565                570                575
Ser Val Gln Pro Ile Val Lys Leu Val Ser Thr Ala Thr Thr Ala Pro 
             580                585                590
Pro Ser Thr Ala Pro Ser Gly Pro Gly Ser Val Gln Lys Tyr Ile Val 
         595                600                605
Val Ser Leu Pro Pro Thr Gly Glu Gly Lys Gly Gly Pro Thr Ser His 
     610                615                620
Pro Ser Pro Val Pro Pro Pro Ala Ser Ser Pro Ser Pro Leu Ser Gly 
 625                630                635                640
Ser Ala Leu Cys Gly Gly Lys Gln Glu Ala Gly Asp Ser Pro Pro Pro 
                 645                650                655
Ala Pro Gly Thr Pro Lys Ala Asn Gly Ser Gln Pro Asn Ser Gly Ser 
             660                665                670
Pro Gln Pro Ala Pro 
         675



<210> 2095
<211> 539
<212> DNA
<213> Rattus norvegicus
<308> D49653
<400> 2095

ccaagaaga  gaagacccc  gcgaggaaa  tgtgctgga  acccctgtg  cggttcctg  60
ggctttggt  ctatctgtc  tatgttcaa  ctgtgccta  ccacaaagt  caggatgac  120
ccaaaaccc  catcaagac  attgtcacc  ggatcaatg  catttcaca  acgcagtcg  180
tatccgcca  gcagagggt  accggtttg  acttcattc  cgggcttca  cccattctg  240
gtttgtcca  gatggacca  accctggca  tctatcaac  gatcctcac  agcttgcct  300
cccaaaacg  gctgcagat  gctcatgac  tggagaacc  gcgagacct  ctccatctg  360
tggccttct  caagagctg  tccctgccg  agacccgtg  cctgcagaa  ccagagagc  420
tggatggcg  cctggaagc  tcgctctac  ccacagagg  ggtggctct  agcaggctg  480
agggctctc  gcaggacat  cttcaacag  tggacctta  ccctgaatg  tgaggtttc  539



<210> 2096
<211> 167
<212> PRT
<213> Rattus norvegicus
<308> P50596
<400> 2096

Met Cys Trp Arg Pro Leu Cys Arg Phe Leu Trp Leu Trp Ser Tyr Leu 
  1               5                  10                  15
Ser Tyr Val Gln Ala Val Pro Ile His Lys Val Gln Asp Asp Thr Lys 
             20                  25                  30
Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
         35                  40                  45
Gln Ser Val Ser Ala Arg Gln Arg Val Thr Gly Leu Asp Phe Ile Pro 
     50                  55                  60
Gly Leu His Pro Ile Leu Ser Leu Ser Lys Met Asp Gln Thr Leu Ala 
 65                  70                  75                  80
Val Tyr Gln Gln Ile Leu Thr Ser Leu Pro Ser Gln Asn Val Leu Gln 
                 85                  90                  95
Ile Ala His Asp Leu Glu Asn Leu Arg Asp Leu Leu His Leu Leu Ala 
             100                105                110
Phe Ser Lys Ser Cys Ser Leu Pro Gln Thr Arg Gly Leu Gln Lys Pro 
         115                120                125
Glu Ser Leu Asp Gly Val Leu Glu Ala Ser Leu Tyr Ser Thr Glu Val 
     130                135                140
Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Ile Leu Gln Gln 
 145                150                155                160
Leu Asp Leu Ser Pro Glu Cys 
                 165



<210> 2097
<211> 504
<212> DNA
<213> Homo sapiens
<308> U18915
<400> 2097

atgcattgg  gaaccctgt  cggattctt  tggctttgg  cctatcttt  ctatgtcca  60
gctgtgccc  tccaaaaag  ccaagatga  accaaaacc  tcatcaaga  aattgtcac  120
aggatcaat  acatttcac  cacgcagtc  gtctcctcc  aacagaaag  caccggttt  180
gacttcatt  ctgggctcc  ccccatcct  accttatcc  agatggacc  gacactggc  240
gtctaccaa  agatcctca  cagtatgcc  tccagaaac  tgatccaaa  atccaacga  300
ctggagaac  tccgggatc  tcttcacgt  ctggccttc  ctaagagct  ccacttgcc  360
tgggccagt  gcctggaga  cttggacag  ctggggggt  tcctggaag  ttcaggcta  420
tccacagag  tggtggccc  gagcaggct  caggggtct  tgcaggaca  gctgtggca  480
ctggacctc  gccctgggt  ctga  504



<210> 2098
<211> 167
<212> PRT
<213> Homo sapiens
<308> P41159
<400> 2098

Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
  1               5                  10                  15
Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
             20                  25                  30
Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
         35                  40                  45
Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
     50                  55                  60
Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala 
 65                  70                  75                  80
Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                 85                  90                  95
Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala 
             100                105                110
Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
         115                120                125
Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
     130                135                140
Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
 145                150                155                160
Leu Asp Leu Ser Pro Gly Cys 
                 165



<210> 2099
<211> 1978
<212> DNA
<213> Rattus norvegicus
<308> D49708
<400> 2099

gtggtgcgg  gcgagtcga  tttggacta  tctcttagc  tggcgtcgc  cgaggctgc  60
gcggagcct  tgtcaggaa  gcgggagct  gacagcttc  gtaaagacc  gcagcggtg  120
cagcaaccc  gagtcatga  cgacagcgg  gagcagaac  acggcgagc  ggaatcccg  180
tctgcttcc  gaagtggaa  tgctcatgg  tcggggaaa  ctgcacggc  cacacctgc  240
aggtctcgc  ccaaggaag  ttcaagacg  tctagatca  agtcaagat  cagatctga  300
tctaggtct  gatccagaa  aagttctag  aggcattat  caaggtcac  atcacgatc  360
cgctctcat  gacgatccc  gagcaggtc  tacagccga  actatcgca  acgccacag  420
cacagccat  ctcccatgt  tactcgaag  cgtcatgtt  ggaaccggg  aaatcctga  480
cccaactgt  gtcttggag  gtttggatt  agcttgtac  ccacagaaa  agatctaag  540
gaagtgttc  ctaagtatg  ccccattgc  gatgtgtct  ttgtgtatg  ccagcagtc  600
agacggtca  gaggatttg  ctttgtata  tttgaaaat  tagatgatg  caaggaagc  660
aaagaacgt  ccaatggaa  ggagcttga  ggacgtcgg  ttagggtcg  tttctctat  720
acaaaaagg  cccataccc  aacaccagg  atttatatg  ggagaccca  ttatggcag  780
tcacgacgc  gggactatt  tgaccgagg  tatgatcgg  gttatgatg  ccgggacta  840
tacagcaga  catacagag  aggaggtgg  ggaggaggt  gatggagag  agctcaaga  900
agagatcag  tttacagaa  gcggtcacc  tctccttac  acagtcgtg  aggatacag  960
tctcgttct  gatcaagat  ctactcacc  cgtcgctat  aaagcatga  gttgaagac  1020
ttctgagac  tgccataga  ctgggatgt  gtttgtgga  aatattttc  attgtctcc  1080
gtttaaaaa  tgaacagtg  ctagtgaag  taggtgact  ttacacctt  tatgatgac  1140
acttttggt  gagttgaaa  gctgttttc  ttctgcatt  gtgtagttc  gtgctttgt  1200
caaagttaa  tgttttcag  aaagtatgt  ttgcatgta  ttttttaca  tccaaattt  1260
gactgctga  aagtttcta  tgtacaaaa  ttcatttaa  aggtttttc  actgaatcc  1320
gggtattct  aagatcgaa  cctgtgtgt  aaatgctac  agatggcaa  aagcaacaa  1380
aaacaagtt  gatttttac  tttctttct  aatatcaat  cttaacaag  accattctt  1440
agttatcag  aaaaaataa  taaataaaa  ttttctttc  ggagtccat  aaacttgcc  1500
tattcgata  acctgcaat  aagtgttaa  aatacgctg  aactctgta  tgctagtat  1560
agaacaaga  tctttccat  cagctaatg  ttaatgctt  cattaatgt  gatttgtcg  1620
cctttatgt  atctgtatt  tatatagca  gggataaga  ctacagata  atacatgcc  1680
ttaaaaggc  gtttcttaa  gctgttaca  ggagataat  gtatttcaa  taatcagca  1740
gtgacaata  attccacca  aaatgtact  ttgttcttc  agcctttag  ctatgaaaa  1800
actgggtgc  tcaaagtat  gaatgagag  agggatcac  acacctgtg  catggatga  1860
gactgcctg  tcatttttt  aatatgatt  tcaggtcct  tgcttacca  aggaagccc  1920
attcactca  atgttttga  aactgttta  ataaacaag  aagaaaaat  gctgatgc  1978



<210> 2100
<211> 288
<212> PRT
<213> Rattus norvegicus
<308> Q15815
<400> 2100

Met Ser Asp Ser Gly Glu Gln Asn Tyr Gly Glu Arg Glu Ser Arg Ser 
  1               5                  10                  15
Ala Ser Arg Ser Gly Ser Ala His Gly Ser Gly Lys Ser Ala Arg His 
             20                  25                  30
Thr Pro Ala Arg Ser Arg Ser Lys Glu Asp Ser Arg Arg Ser Arg Ser 
         35                  40                  45
Lys Ser Arg Ser Arg Ser Glu Ser Arg Ser Arg Ser Arg Arg Ser Ser 
     50                  55                  60
Arg Arg His Tyr Thr Arg Ser Arg Ser Arg Ser Arg Ser His Arg Arg 
 65                  70                  75                  80
Ser Arg Ser Arg Ser Tyr Ser Arg Asp Tyr Arg Arg Arg His Ser His 
                 85                  90                  95
Ser His Ser Pro Met Ser Thr Arg Arg Arg His Val Gly Asn Arg Ala 
             100                105                110
Asn Pro Asp Pro Asn Cys Cys Leu Gly Val Phe Gly Leu Ser Leu Tyr 
         115                120                125
Thr Thr Glu Arg Asp Leu Arg Glu Val Phe Ser Lys Tyr Gly Pro Ile 
     130                135                140
Ala Asp Val Ser Ile Val Tyr Asp Gln Gln Ser Arg Arg Ser Arg Gly 
 145                150                155                160
Phe Ala Phe Val Tyr Phe Glu Asn Val Asp Asp Ala Lys Glu Ala Lys 
                 165                170                175
Glu Arg Ala Asn Gly Met Glu Leu Asp Gly Arg Arg Ile Arg Val Asp 
             180                185                190
Phe Ser Ile Thr Lys Arg Pro His Thr Pro Thr Pro Gly Ile Tyr Met 
         195                200                205
Gly Arg Pro Thr Tyr Gly Ser Ser Arg Arg Arg Asp Tyr Tyr Asp Arg 
     210                215                220
Gly Tyr Asp Arg Gly Tyr Asp Asp Arg Asp Tyr Tyr Ser Arg Ser Tyr 
 225                230                235                240
Arg Gly Gly Gly Gly Gly Gly Gly Gly Trp Arg Ala Ala Gln Asp Arg 
                 245                250                255
Asp Gln Ile Tyr Arg Arg Arg Ser Pro Ser Pro Tyr Tyr Ser Arg Gly 
             260                265                270
Gly Tyr Arg Ser Arg Ser Arg Ser Arg Ser Tyr Ser Pro Arg Arg Tyr 
         275                280                285



<210> 2101
<211> 1430
<212> DNA
<213> Homo sapiens
<308> BC000451
<400> 2101

ggcacgagg  aggcggtgc  gagcatttc  gctctgagc  gctgggcga  cggcgcgtc  60
tgcggggct  cggcggagc  tccttaagg  aggtgcaag  ggttggcag  ttcgattga  120
gcacatcga  cggcgacag  agccaggag  catgagcga  agcggcgag  agaactacg  180
cgagcggga  tcccgttct  cttccagaa  tggaagtgc  cacggatcg  ggaaatctg  240
aaggcatac  cctgcaagg  ctcgctcca  ggaagattc  aggcgttcc  gatcaaagt  300
caggtcccg  tctgaatct  ggtctagat  cagaagaag  tcccgaagg  attataccc  360
gtcacggtc  cgctcccgc  cccatagac  atcacgtag  aggtcttac  gtcgagatt  420
tcgtagacg  cacagccac  gccattctc  catgtctac  cgcaggcgt  atgttggga  480
tcgggcaaa  cctgatcct  actgttgtc  tggagtatt  gggctgagc  tgtacacca  540
agaaagaga  ctaagagaa  tgttctcta  atatggtcc  attgccgat  tgtctattg  600
atatgacca  cagtctagg  gttcaagag  atttgcctt  gtatatttt  aaaatgtag  660
tgatgccaa  gaagctaaa  aacgtgcca  tggaatgga  cttgatggg  gtaggatca  720
agttgattt  tctataaca  aaagaccac  tacgccaac  ccaggaatt  acatgggga  780
acctaccta  ggcagctct  gccgtcggg  ttactatga  agaggatat  atcggggct  840
tgatgatcg  gactactat  gcagatcat  cagaggagg  ggtggagga  gaggaggat  900
gagagctgc  caagacagg  atcagattt  tagaaggcg  tcaccttct  cttactata  960
tcgtggagg  tacagatca  gttccagat  tcgatcata  tcacctcgt  gctattaaa  1020
catgaagac  ttctgaaac  tgccctaga  ctgggatat  gtttgtggg  aatattttt  1080
attgtctct  gtttaaaaa  tgaacagtg  ctagtgaag  taggtgact  ttacacctt  1140
tacgatgac  acttttggt  gagttgaaa  gctgttttc  ttctgcatt  gtgtagttt  1200
gtgctttgt  ccaagttaa  tgttttcag  aaagtatgt  ttgcatgta  ttttttaca  1260
tctaaattt  gactgctga  aagtttcta  tgtacaaaa  ttcatttaa  aggtttttc  1320
actgaatcc  gggtattct  aagatcgaa  cctgtgtaa  atgctacca  atggcaaaa  1380
gcaacaata  acagtttga  ttttaaaaa  aaaaaaaaa  aaaaaaaaaa  1430



<210> 2102
<211> 288
<212> PRT
<213> Homo sapiens
<308> Q15815
<400> 2102

Met Ser Asp Ser Gly Glu Gln Asn Tyr Gly Glu Arg Glu Ser Arg Ser 
  1               5                  10                  15
Ala Ser Arg Ser Gly Ser Ala His Gly Ser Gly Lys Ser Ala Arg His 
             20                  25                  30
Thr Pro Ala Arg Ser Arg Ser Lys Glu Asp Ser Arg Arg Ser Arg Ser 
         35                  40                  45
Lys Ser Arg Ser Arg Ser Glu Ser Arg Ser Arg Ser Arg Arg Ser Ser 
     50                  55                  60
Arg Arg His Tyr Thr Arg Ser Arg Ser Arg Ser Arg Ser His Arg Arg 
 65                  70                  75                  80
Ser Arg Ser Arg Ser Tyr Ser Arg Asp Tyr Arg Arg Arg His Ser His 
                 85                  90                  95
Ser His Ser Pro Met Ser Thr Arg Arg Arg His Val Gly Asn Arg Ala 
             100                105                110
Asn Pro Asp Pro Asn Cys Cys Leu Gly Val Phe Gly Leu Ser Leu Tyr 
         115                120                125
Thr Thr Glu Arg Asp Leu Arg Glu Val Phe Ser Lys Tyr Gly Pro Ile 
     130                135                140
Ala Asp Val Ser Ile Val Tyr Asp Gln Gln Ser Arg Arg Ser Arg Gly 
 145                150                155                160
Phe Ala Phe Val Tyr Phe Glu Asn Val Asp Asp Ala Lys Glu Ala Lys 
                 165                170                175
Glu Arg Ala Asn Gly Met Glu Leu Asp Gly Arg Arg Ile Arg Val Asp 
             180                185                190
Phe Ser Ile Thr Lys Arg Pro His Thr Pro Thr Pro Gly Ile Tyr Met 
         195                200                205
Gly Arg Pro Thr Tyr Gly Ser Ser Arg Arg Arg Asp Tyr Tyr Asp Arg 
     210                215                220
Gly Tyr Asp Arg Gly Tyr Asp Asp Arg Asp Tyr Tyr Ser Arg Ser Tyr 
 225                230                235                240
Arg Gly Gly Gly Gly Gly Gly Gly Gly Trp Arg Ala Ala Gln Asp Arg 
                 245                250                255
Asp Gln Ile Tyr Arg Arg Arg Ser Pro Ser Pro Tyr Tyr Ser Arg Gly 
             260                265                270
Gly Tyr Arg Ser Arg Ser Arg Ser Arg Ser Tyr Ser Pro Arg Arg Tyr 
         275                280                285



<210> 2103
<211> 1978
<212> DNA
<213> Rattus norvegicus
<308> D49708
<400> 2103

gtggtgcgg  gcgagtcga  tttggacta  tctcttagc  tggcgtcgc  cgaggctgc  60
gcggagcct  tgtcaggaa  gcgggagct  gacagcttc  gtaaagacc  gcagcggtg  120
cagcaaccc  gagtcatga  cgacagcgg  gagcagaac  acggcgagc  ggaatcccg  180
tctgcttcc  gaagtggaa  tgctcatgg  tcggggaaa  ctgcacggc  cacacctgc  240
aggtctcgc  ccaaggaag  ttcaagacg  tctagatca  agtcaagat  cagatctga  300
tctaggtct  gatccagaa  aagttctag  aggcattat  caaggtcac  atcacgatc  360
cgctctcat  gacgatccc  gagcaggtc  tacagccga  actatcgca  acgccacag  420
cacagccat  ctcccatgt  tactcgaag  cgtcatgtt  ggaaccggg  aaatcctga  480
cccaactgt  gtcttggag  gtttggatt  agcttgtac  ccacagaaa  agatctaag  540
gaagtgttc  ctaagtatg  ccccattgc  gatgtgtct  ttgtgtatg  ccagcagtc  600
agacggtca  gaggatttg  ctttgtata  tttgaaaat  tagatgatg  caaggaagc  660
aaagaacgt  ccaatggaa  ggagcttga  ggacgtcgg  ttagggtcg  tttctctat  720
acaaaaagg  cccataccc  aacaccagg  atttatatg  ggagaccca  ttatggcag  780
tcacgacgc  gggactatt  tgaccgagg  tatgatcgg  gttatgatg  ccgggacta  840
tacagcaga  catacagag  aggaggtgg  ggaggaggt  gatggagag  agctcaaga  900
agagatcag  tttacagaa  gcggtcacc  tctccttac  acagtcgtg  aggatacag  960
tctcgttct  gatcaagat  ctactcacc  cgtcgctat  aaagcatga  gttgaagac  1020
ttctgagac  tgccataga  ctgggatgt  gtttgtgga  aatattttc  attgtctcc  1080
gtttaaaaa  tgaacagtg  ctagtgaag  taggtgact  ttacacctt  tatgatgac  1140
acttttggt  gagttgaaa  gctgttttc  ttctgcatt  gtgtagttc  gtgctttgt  1200
caaagttaa  tgttttcag  aaagtatgt  ttgcatgta  ttttttaca  tccaaattt  1260
gactgctga  aagtttcta  tgtacaaaa  ttcatttaa  aggtttttc  actgaatcc  1320
gggtattct  aagatcgaa  cctgtgtgt  aaatgctac  agatggcaa  aagcaacaa  1380
aaacaagtt  gatttttac  tttctttct  aatatcaat  cttaacaag  accattctt  1440
agttatcag  aaaaaataa  taaataaaa  ttttctttc  ggagtccat  aaacttgcc  1500
tattcgata  acctgcaat  aagtgttaa  aatacgctg  aactctgta  tgctagtat  1560
agaacaaga  tctttccat  cagctaatg  ttaatgctt  cattaatgt  gatttgtcg  1620
cctttatgt  atctgtatt  tatatagca  gggataaga  ctacagata  atacatgcc  1680
ttaaaaggc  gtttcttaa  gctgttaca  ggagataat  gtatttcaa  taatcagca  1740
gtgacaata  attccacca  aaatgtact  ttgttcttc  agcctttag  ctatgaaaa  1800
actgggtgc  tcaaagtat  gaatgagag  agggatcac  acacctgtg  catggatga  1860
gactgcctg  tcatttttt  aatatgatt  tcaggtcct  tgcttacca  aggaagccc  1920
attcactca  atgttttga  aactgttta  ataaacaag  aagaaaaat  gctgatgc  1978



<210> 2104
<211> 288
<212> PRT
<213> Rattus norvegicus
<308> Q15815
<400> 2104

Met Ser Asp Ser Gly Glu Gln Asn Tyr Gly Glu Arg Glu Ser Arg Ser 
  1               5                  10                  15
Ala Ser Arg Ser Gly Ser Ala His Gly Ser Gly Lys Ser Ala Arg His 
             20                  25                  30
Thr Pro Ala Arg Ser Arg Ser Lys Glu Asp Ser Arg Arg Ser Arg Ser 
         35                  40                  45
Lys Ser Arg Ser Arg Ser Glu Ser Arg Ser Arg Ser Arg Arg Ser Ser 
     50                  55                  60
Arg Arg His Tyr Thr Arg Ser Arg Ser Arg Ser Arg Ser His Arg Arg 
 65                  70                  75                  80
Ser Arg Ser Arg Ser Tyr Ser Arg Asp Tyr Arg Arg Arg His Ser His 
                 85                  90                  95
Ser His Ser Pro Met Ser Thr Arg Arg Arg His Val Gly Asn Arg Ala 
             100                105                110
Asn Pro Asp Pro Asn Cys Cys Leu Gly Val Phe Gly Leu Ser Leu Tyr 
         115                120                125
Thr Thr Glu Arg Asp Leu Arg Glu Val Phe Ser Lys Tyr Gly Pro Ile 
     130                135                140
Ala Asp Val Ser Ile Val Tyr Asp Gln Gln Ser Arg Arg Ser Arg Gly 
 145                150                155                160
Phe Ala Phe Val Tyr Phe Glu Asn Val Asp Asp Ala Lys Glu Ala Lys 
                 165                170                175
Glu Arg Ala Asn Gly Met Glu Leu Asp Gly Arg Arg Ile Arg Val Asp 
             180                185                190
Phe Ser Ile Thr Lys Arg Pro His Thr Pro Thr Pro Gly Ile Tyr Met 
         195                200                205
Gly Arg Pro Thr Tyr Gly Ser Ser Arg Arg Arg Asp Tyr Tyr Asp Arg 
     210                215                220
Gly Tyr Asp Arg Gly Tyr Asp Asp Arg Asp Tyr Tyr Ser Arg Ser Tyr 
 225                230                235                240
Arg Gly Gly Gly Gly Gly Gly Gly Gly Trp Arg Ala Ala Gln Asp Arg 
                 245                250                255
Asp Gln Ile Tyr Arg Arg Arg Ser Pro Ser Pro Tyr Tyr Ser Arg Gly 
             260                265                270
Gly Tyr Arg Ser Arg Ser Arg Ser Arg Ser Tyr Ser Pro Arg Arg Tyr 
         275                280                285



<210> 2105
<211> 1430
<212> DNA
<213> Homo sapiens
<308> BC000451
<400> 2105

ggcacgagg  aggcggtgc  gagcatttc  gctctgagc  gctgggcga  cggcgcgtc  60
tgcggggct  cggcggagc  tccttaagg  aggtgcaag  ggttggcag  ttcgattga  120
gcacatcga  cggcgacag  agccaggag  catgagcga  agcggcgag  agaactacg  180
cgagcggga  tcccgttct  cttccagaa  tggaagtgc  cacggatcg  ggaaatctg  240
aaggcatac  cctgcaagg  ctcgctcca  ggaagattc  aggcgttcc  gatcaaagt  300
caggtcccg  tctgaatct  ggtctagat  cagaagaag  tcccgaagg  attataccc  360
gtcacggtc  cgctcccgc  cccatagac  atcacgtag  aggtcttac  gtcgagatt  420
tcgtagacg  cacagccac  gccattctc  catgtctac  cgcaggcgt  atgttggga  480
tcgggcaaa  cctgatcct  actgttgtc  tggagtatt  gggctgagc  tgtacacca  540
agaaagaga  ctaagagaa  tgttctcta  atatggtcc  attgccgat  tgtctattg  600
atatgacca  cagtctagg  gttcaagag  atttgcctt  gtatatttt  aaaatgtag  660
tgatgccaa  gaagctaaa  aacgtgcca  tggaatgga  cttgatggg  gtaggatca  720
agttgattt  tctataaca  aaagaccac  tacgccaac  ccaggaatt  acatgggga  780
acctaccta  ggcagctct  gccgtcggg  ttactatga  agaggatat  atcggggct  840
tgatgatcg  gactactat  gcagatcat  cagaggagg  ggtggagga  gaggaggat  900
gagagctgc  caagacagg  atcagattt  tagaaggcg  tcaccttct  cttactata  960
tcgtggagg  tacagatca  gttccagat  tcgatcata  tcacctcgt  gctattaaa  1020
catgaagac  ttctgaaac  tgccctaga  ctgggatat  gtttgtggg  aatattttt  1080
attgtctct  gtttaaaaa  tgaacagtg  ctagtgaag  taggtgact  ttacacctt  1140
tacgatgac  acttttggt  gagttgaaa  gctgttttc  ttctgcatt  gtgtagttt  1200
gtgctttgt  ccaagttaa  tgttttcag  aaagtatgt  ttgcatgta  ttttttaca  1260
tctaaattt  gactgctga  aagtttcta  tgtacaaaa  ttcatttaa  aggtttttc  1320
actgaatcc  gggtattct  aagatcgaa  cctgtgtaa  atgctacca  atggcaaaa  1380
gcaacaata  acagtttga  ttttaaaaa  aaaaaaaaa  aaaaaaaaaa  1430



<210> 2106
<211> 288
<212> PRT
<213> Homo sapiens
<308> Q15815
<400> 2106

Met Ser Asp Ser Gly Glu Gln Asn Tyr Gly Glu Arg Glu Ser Arg Ser 
  1               5                  10                  15
Ala Ser Arg Ser Gly Ser Ala His Gly Ser Gly Lys Ser Ala Arg His 
             20                  25                  30
Thr Pro Ala Arg Ser Arg Ser Lys Glu Asp Ser Arg Arg Ser Arg Ser 
         35                  40                  45
Lys Ser Arg Ser Arg Ser Glu Ser Arg Ser Arg Ser Arg Arg Ser Ser 
     50                  55                  60
Arg Arg His Tyr Thr Arg Ser Arg Ser Arg Ser Arg Ser His Arg Arg 
 65                  70                  75                  80
Ser Arg Ser Arg Ser Tyr Ser Arg Asp Tyr Arg Arg Arg His Ser His 
                 85                  90                  95
Ser His Ser Pro Met Ser Thr Arg Arg Arg His Val Gly Asn Arg Ala 
             100                105                110
Asn Pro Asp Pro Asn Cys Cys Leu Gly Val Phe Gly Leu Ser Leu Tyr 
         115                120                125
Thr Thr Glu Arg Asp Leu Arg Glu Val Phe Ser Lys Tyr Gly Pro Ile 
     130                135                140
Ala Asp Val Ser Ile Val Tyr Asp Gln Gln Ser Arg Arg Ser Arg Gly 
 145                150                155                160
Phe Ala Phe Val Tyr Phe Glu Asn Val Asp Asp Ala Lys Glu Ala Lys 
                 165                170                175
Glu Arg Ala Asn Gly Met Glu Leu Asp Gly Arg Arg Ile Arg Val Asp 
             180                185                190
Phe Ser Ile Thr Lys Arg Pro His Thr Pro Thr Pro Gly Ile Tyr Met 
         195                200                205
Gly Arg Pro Thr Tyr Gly Ser Ser Arg Arg Arg Asp Tyr Tyr Asp Arg 
     210                215                220
Gly Tyr Asp Arg Gly Tyr Asp Asp Arg Asp Tyr Tyr Ser Arg Ser Tyr 
 225                230                235                240
Arg Gly Gly Gly Gly Gly Gly Gly Gly Trp Arg Ala Ala Gln Asp Arg 
                 245                250                255
Asp Gln Ile Tyr Arg Arg Arg Ser Pro Ser Pro Tyr Tyr Ser Arg Gly 
             260                265                270
Gly Tyr Arg Ser Arg Ser Arg Ser Arg Ser Tyr Ser Pro Arg Arg Tyr 
         275                280                285



<210> 2107
<211> 3754
<212> DNA
<213> Rattus norvegicus
<308> D49785
<400> 2107

ttggaagga  cgggagttc  agtcgagtg  gaacggggc  tagagtagt  ggtgggggg  60
caaaagctg  ggctgacac  cgtgcacct  agctccact  gagcatcgc  ggtgacagc  120
ctccaggtc  agtggaggg  aacgggggg  ggaggggag  aggaggagg  ggcgggagc  180
gcatccgga  ccgagctgc  gcagcgccg  cttttgtgc  gcggccgcg  agcccccga  240
ggccttgga  cccctggaa  tggagttat  ggggttgtg  gcatcatgt  gatgctggg  300
atggaaccc  agtcatctc  aagaacacc  aggctggcc  gaaactcac  gtgaagcca  360
agatgacct  ggacttctg  gcctctcac  tccattcct  agtgctggg  ctgctgggc  420
cgctactca  cacacctgg  tccagaggc  atggcctgc  tccatgaaa  ccgaacacc  480
tccccttcc  ttggaggct  tgtgtctac  ctaagtgag  cctccatgc  aaagctgga  540
ccagacact  cagactgca  ccctgagaa  gacctgaca  ctacccaat  tgtacttcg  600
gatgttgtg  ctctcggtg  gcagggtgg  ggagggccc  gcccctccc  aggtggaga  660
cctcctcca  agccttttg  caatagtgt  ctgcagcta  atgagcagg  tacaggtgg  720
ccaggggga  ccaccgggt  acctgagag  cgagcatct  gggttcgag  tgatgaggt  780
cgtctgcag  gccagagtg  cagtggctt  cttgaaggt  tttttggct  cctgcgccc  840
gtctggaca  tgattggca  agcctactc  acagagcac  agcaacagc  ggaagacct  900
tgggaagtc  cctttgagg  aatcctgga  ctgcagtgg  taggctcag  ggctcaggg  960
gccgttttc  tgggacgct  tcatgggga  gaggtagct  tgaagaagg  tcgagacct  1020
aaggagacc  acatcaagc  tcttcgaaa  ctgaagcac  ccaacatca  cactttcaa  1080
ggtgtttgc  cacaggccc  gtgctactg  atcctcatg  agttctgtg  ccaaggaca  1140
ctgtatgag  tgctcaggg  gggccgccc  gttaccccc  ccttgctgg  tgactggtc  1200
atgggcatc  ctggaggca  gaattacct  cacctgcac  aaatcatcc  cagagacct  1260
aagtcaccc  acatgctaa  cacatacga  gatgtggtg  agatctcag  ctttggcac  1320
tccaaggag  tgagtgaca  gagcaccaa  atgtccttt  cagggacag  agcctggat  1380
gctcctgaa  tgatcagaa  tgaacctgt  tctgagaag  ttgacatct  gtcctttgg  1440
gtggtgctt  gggaattac  gactggaga  attccctac  aagatgtag  ctcctcagc  1500
atcatctgg  gtgtgggaa  caacagtct  cacctgcct  taccctcta  ctgcccaga  1560
ggctttaaa  ttctgcttc  ccagtgctg  aacagaaaa  ctcggaacc  cccatcatt  1620
cgacagatc  tgctgcacc  ggacatcgc  tcggctgat  tgctctcta  accccagga  1680
acttacttt  aatcccagg  agagtggcg  gaagaagta  aactgcact  tgaaaagat  1740
aagtcagaa  ggacctgtc  gcaccgcct  gaagaggaa  tggtgatgc  gagaaggga  1800
gagctcaga  atgccctgg  catcaggga  cactatgag  gcaagttgg  gagagctaa  1860
aacttgtac  tggaactga  tgccctcat  ttgcaacta  aactcaaag  gagggaatt  1920
ctcaggcga  agcaagctt  agaaaggag  tgtcctggt  tactgaagt  acacacgtc  1980
cgaagcctc  tacatggaa  cacgatgga  aagctcatc  agaaaagga  tgtgccaca  2040
aaactgtca  cccatagca  aaggccaga  attctcaag  cagagtctt  gctacctaa  2100
ctagatgca  ccctaagtg  ggtggggct  cctggttgt  ctaaggccc  cccttcacc  2160
gggaggagt  gtcgtggca  gacccgtca  cgaaaggcc  gcgccaagg  cagctgtgg  2220
gacctgcct  ggcttcgtg  agctttgcc  ccccatgag  ctggaggac  aggaagccc  2280
ggaggccta  gagtgggcc  tacagcttg  gatgcctcc  cccctgctc  ccgtggact  2340
caccatgac  ttctacttc  gaagatgtc  tcatcatcc  cagacctgt  atcagcagc  2400
ctgggagcc  gaggccgag  ggcaacagg  ggagctcgg  atcctggct  accacctcc  2460
ccccagggt  atactcctc  aagtgaggg  tcagctcct  gttccacca  cccagattc  2520
cctggggga  ctaaagggg  accacctcc  ccagtaggg  ctggagaag  tgtggggct  2580
ctgggaact  gaagggaag  gactacagg  cggggagga  gccgggctg  gtaccagca  2640
ttgaccccc  ctgcgctgc  gtacagggc  gctgtgact  gtagtcaga  acgtggtat  2700
tcatctgaa  aggaagaag  agaggtcga  agtgaagta  agctacccc  aagtcaaag  2760
tggcctcag  gcccgaaca  gcgtcagtc  ctatctacg  tcagctcag  gaacccatc  2820
gatgtggag  aaggtacag  tagtgagcc  tccccaagt  gcacaccgg  agttggcag  2880
accaacact  atgagcgac  agatgaacg  tctgatgac  tgtgctcac  gggttcaga  2940
atcccactg  acctaccta  ttcagaggt  gtccctgaa  gtgaaacca  ctccttgcc  3000
atgcaacac  aggatgacc  gggccccaa  cctgaggac  cagactgtg  cagcactga  3060
ttggacaac  ccaacagca  tgatgcctt  ccgccccca  cctcccttc  tccatgaaa  3120
acactctta  tccttgtac  tagagaaat  tttatataa  taatatata  gcgccacat  3180
atcaacaga  agacggggc  ttcttagcc  taagtcagg  ttcagagtg  acgacgccc  3240
tgaccaatt  agttctagg  acactggca  ctgtggaaa  gactccaag  actacccta  3300
agctgtaag  aaaggacac  ggtcccttc  tgcttcacc  cattcctta  gttgaacaa  3360
caagtaggc  tagaaaagc  aggcttgtc  ctacactgt  tgtccctaa  catgggggg  3420
aggaagagg  ttcacttaa  actgcactt  tattttccg  ttactgttt  cacattttg  3480
acttgggag  agggaaact  aggctgggt  ctaggtcct  cctctgagg  ttctcaggt  3540
gcaatgtaa  tcatttctt  gttcctgtt  ctctgccaa  gccctggct  tgggcccag  3600
ggcaagtta  aagattaat  gcatgtgat  gctcaggct  aagaactgg  tgctggtta  3660
gtccccgct  ttatctggt  cctggtagg  gtggggact  tcatattgt  acccctgtg  3720
acaaccctg  aatataacc  ctccatgca  gccc  3754



<210> 2108
<211> 888
<212> PRT
<213> Rattus norvegicus
<308> Q63796
<400> 2108

Met Ala Cys Leu His Glu Thr Arg Thr Pro Ser Pro Ser Phe Gly Gly 
  1               5                  10                  15
Phe Val Ser Thr Leu Ser Glu Ala Ser Met Arg Lys Leu Asp Pro Asp 
             20                  25                  30
Thr Ser Asp Cys Thr Pro Glu Lys Asp Leu Thr Pro Thr Gln Cys Val 
         35                  40                  45
Leu Arg Asp Val Val Pro Leu Gly Gly Gln Gly Gly Gly Gly Pro Ser 
     50                  55                  60
Pro Ser Pro Gly Gly Glu Pro Pro Pro Glu Pro Phe Ala Asn Ser Val 
 65                  70                  75                  80
Leu Gln Leu His Glu Gln Asp Thr Gly Gly Pro Gly Gly Ala Thr Gly 
                 85                  90                  95
Ser Pro Glu Ser Arg Ala Ser Arg Val Arg Ala Asp Glu Val Arg Leu 
             100                105                110
Gln Cys Gln Ser Gly Ser Gly Phe Leu Glu Gly Leu Phe Gly Cys Leu 
         115                120                125
Arg Pro Val Trp Thr Met Ile Gly Lys Ala Tyr Ser Thr Glu His Lys 
     130                135                140
Gln Gln Gln Glu Asp Leu Trp Glu Val Pro Phe Glu Glu Ile Leu Asp 
 145                150                155                160
Leu Gln Trp Val Gly Ser Gly Ala Gln Gly Ala Val Phe Leu Gly Arg 
                 165                170                175
Phe His Gly Glu Glu Val Ala Val Lys Lys Val Arg Asp Leu Lys Glu 
             180                185                190
Thr Asp Ile Lys His Leu Arg Lys Leu Lys His Pro Asn Ile Ile Thr 
         195                200                205
Phe Lys Gly Val Cys Thr Gln Ala Pro Cys Tyr Cys Ile Leu Met Glu 
     210                215                220
Phe Cys Ala Gln Gly Gln Leu Tyr Glu Val Leu Arg Ala Gly Arg Pro 
 225                230                235                240
Val Thr Pro Ser Leu Leu Val Asp Trp Ser Met Gly Ile Ala Gly Gly 
                 245                250                255
Met Asn Tyr Leu His Leu His Lys Ile Ile His Arg Asp Leu Lys Ser 
             260                265                270
Pro Asn Met Leu Ile Thr Tyr Asp Asp Val Val Lys Ile Ser Asp Phe 
         275                280                285
Gly Thr Ser Lys Glu Leu Ser Asp Lys Ser Thr Lys Met Ser Phe Ala 
     290                295                300
Gly Thr Val Ala Trp Met Ala Pro Glu Val Ile Arg Asn Glu Pro Val 
 305                310                315                320
Ser Glu Lys Val Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Leu 
                 325                330                335
Leu Thr Gly Glu Ile Pro Tyr Lys Asp Val Asp Ser Ser Ala Ile Ile 
             340                345                350
Trp Gly Val Gly Ser Asn Ser Leu His Leu Pro Val Pro Ser Ser Cys 
         355                360                365
Pro Asp Gly Phe Lys Ile Leu Leu Arg Gln Cys Trp Asn Arg Lys Pro 
     370                375                380
Arg Asn Arg Pro Ser Phe Arg Gln Ile Leu Leu His Leu Asp Ile Ala 
 385                390                395                400
Ser Ala Asp Val Leu Ser Thr Pro Gln Glu Thr Tyr Phe Lys Ser Gln 
                 405                410                415
Ala Glu Trp Arg Glu Glu Val Lys Leu His Phe Glu Lys Ile Lys Ser 
             420                425                430
Glu Gly Thr Cys Leu His Arg Leu Glu Glu Glu Leu Val Met Arg Arg 
         435                440                445
Arg Glu Glu Leu Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg 
     450                455                460
Lys Leu Glu Arg Ala Asn Asn Leu Tyr Met Glu Leu Asn Ala Leu Met 
 465                470                475                480
Leu Gln Leu Glu Leu Lys Glu Arg Glu Leu Leu Arg Arg Glu Gln Ala 
                 485                490                495
Leu Glu Arg Arg Cys Pro Gly Leu Leu Lys Ser His Thr Ser Arg Ser 
             500                505                510
Leu Leu His Gly Asn Thr Met Glu Lys Leu Ile Lys Lys Arg Asn Val 
         515                520                525
Pro Gln Lys Leu Ser Pro His Ser Lys Arg Pro Asp Ile Leu Lys Thr 
     530                535                540
Glu Ser Leu Leu Pro Lys Leu Asp Ala Ala Leu Ser Gly Val Gly Leu 
 545                550                555                560
Pro Gly Cys Pro Lys Ala Pro Pro Ser Pro Gly Arg Ser Arg Arg Gly 
                 565                570                575
Lys Thr Arg His Arg Lys Ala Ser Ala Lys Gly Ser Cys Gly Asp Leu 
             580                585                590
Pro Gly Leu Arg Ala Ala Leu Pro Pro His Glu Pro Gly Gly Leu Gly 
         595                600                605
Ser Pro Gly Gly Leu Gly Val Gly Pro Thr Ala Trp Asp Ala Ser Pro 
     610                615                620
Pro Ala Leu Arg Gly Leu His His Asp Leu Leu Leu Arg Lys Met Ser 
 625                630                635                640
Ser Ser Ser Pro Asp Leu Leu Ser Ala Ala Leu Gly Ala Arg Gly Arg 
                 645                650                655
Gly Ala Thr Gly Gly Ala Arg Asp Pro Gly Ser Pro Pro Pro Pro Gln 
             660                665                670
Gly Asp Thr Pro Pro Ser Glu Gly Ser Ala Pro Gly Ser Thr Ser Pro 
         675                680                685
Asp Ser Pro Gly Gly Ala Lys Gly Glu Pro Pro Pro Pro Val Gly Pro 
     690                695                700
Gly Glu Gly Val Gly Leu Leu Gly Thr Gly Arg Glu Gly Thr Thr Gly 
 705                710                715                720
Arg Gly Gly Ser Arg Ala Gly Tyr Gln His Leu Thr Pro Ala Ala Leu 
                 725                730                735
Leu Tyr Arg Ala Ala Val Thr Arg Ser Gln Lys Arg Gly Ile Ser Ser 
             740                745                750
Glu Glu Glu Glu Gly Glu Val Asp Ser Glu Val Glu Leu Pro Pro Ser 
         755                760                765
Gln Arg Trp Pro Gln Gly Pro Asn Met Arg Gln Ser Leu Ser Thr Phe 
     770                775                780
Ser Ser Glu Asn Pro Ser Asp Val Glu Glu Gly Thr Ala Ser Glu Pro 
 785                790                795                800
Ser Pro Ser Gly Thr Pro Glu Val Gly Ser Thr Asn Thr Asp Glu Arg 
                 805                810                815
Pro Asp Glu Arg Ser Asp Asp Met Cys Ser Gln Gly Ser Glu Ile Pro 
             820                825                830
Leu Asp Leu Pro Thr Ser Glu Val Val Pro Glu Arg Glu Thr Ser Ser 
         835                840                845
Leu Pro Met Gln His Gln Asp Asp Gln Gly Pro Asn Pro Glu Asp Ser 
     850                855                860
Asp Cys Asp Ser Thr Glu Leu Asp Asn Ser Asn Ser Ile Asp Ala Leu 
 865                870                875                880
Pro Pro Pro Ala Ser Leu Pro Pro 
                 885



<210> 2109
<211> 3365
<212> DNA
<213> Homo sapiens
<308> U07358
<400> 2109

agcatccgg  gcggagctg  agcagcgcc  ccttttgtg  tgcggccgc  gagcccccg  60
gggcccagt  ttcaccatc  taccagggg  cagaggcga  ggcttgcct  catgagacc  120
gaacaccct  tccttcctt  gggggcttt  tgtctaccc  aagtgaggc  tccatgcgc  180
agctggacc  agacacttc  gactgcact  ccgagaagg  cctgacgcc  acccatgtc  240
tgcagctac  tgagcagga  gcagggggc  cagggggag  agctgggtc  cctgagagt  300
gggcatcca  agttcgagc  gacgaggtg  gactgcagt  ccagagtgg  agtggcttc  360
ttgagggcc  ctttggctg  ctgcgccct  tctggacca  gattggcaa  gcctactcc  420
ctgagcaca  gcagcagca  gaagacctt  gggaggtcc  ctttgagga  atcctggac  480
tgcagtggg  gggctcagg  gcccagggt  ctgtcttcc  ggggcgctt  cacggggag  540
aggtggctg  gaagaaggt  cgagacctc  aagaaaccg  catcaagca  ttgcgaaag  600
tgaagcacc  caacatcat  actttcaag  gtgtgtgca  ccaggctcc  tgctactgc  660
tcctcatgg  gttctgcgc  cagggccag  tgtatgagg  actgcgggc  ggccgccct  720
tcaccccct  cttactggt  gactggtcc  tgggcatcg  tggtggcat  aactacctg  780
acctgcaca  gattatcca  agggatctc  agtcaccca  catgctaat  acctacgac  840
atgtggtga  gatctcaga  tttggcact  ccaaggagc  gagtgacaa  agcaccaag  900
tgtcctttg  agggacagt  gcctggatg  cccctgagg  gatccgcaa  gaacctgtg  960
ctgagaagg  cgacatctg  tcctttggc  tggtgctat  ggaactgct  actggtgag  1020
tcccctaca  agacgtaga  tcctcagcc  ttatctggg  tgtgggaag  aacagtctc  1080
atctgcccg  gccctccag  tgcccagat  gtttcaaga  cctgcttcg  cagtgctgg  1140
atagcaaac  acgaaatcg  ccatcattc  gacagatcc  gctgcatct  gacattgcc  1200
cagctgatg  actctccac  ccccaggag  cttacttta  gtcccaggc  gagtggcgg  1260
aagaagtaa  actgcactt  gaaaagatt  agtcagaag  gacctgtct  caccgccta  1320
aagaggaac  ggtgatgag  aggagggag  agctcagac  cgccctgga  atcagggag  1380
actatgaaa  gaagctgga  agagccaac  acctgtata  ggaacttaa  gccctcatg  1440
tgcagctgg  actcaagga  agggagctg  tcaggcgag  gcaagcttt  gagcggagg  1500
gcccaggcc  gctgaagcc  cacccttcc  ggggcctcc  gcatggaaa  acaatggag  1560
agcttatca  gaagaggaa  gtgccacag  atctgtcac  ccatagcca  aggccagat  1620
tcctcaagg  ggagtcttt  ctccctaaa  tagatgcag  cctgagtgg  gtggggctt  1680
ctgggtgtc  taaggcccc  ccctcacca  gacggagtc  ccgtggcaa  acccgtcac  1740
gcaaggcca  cgccaaggg  agctgtggg  acctgcctg  gcttcgtac  gctgtgcca  1800
cccatgaac  tggaggacc  ggaagccca  ggggcctag  agggggacc  tcagcctgg  1860
aggcctgcc  tcccgccct  cgtgggctt  atcatgacc  cctgctccg  aaaatgtct  1920
catcgtccc  agacctgct  tcagcagca  tagggtccc  gggccgggg  gccacaggc  1980
gagctgggg  tcctggctc  ccacctccg  cccggggtg  caccccacc  agtgagggc  2040
cagcccctg  ctccaccag  ccagattca  ctgggggag  caaagggga  ccacctcct  2100
cagtagggc  tggtgaagg  gtggggctt  tgggaactg  aagggaagg  acctcaggc  2160
ggggaggaa  ccgggctgg  tcccagcac  tgaccccag  tgcactgct  tacagggct  2220
ccgtcaccc  aagtcagaa  cgtggcatc  catcggaag  ggaggaagg  gaggtagac  2280
gtgaagtag  gctgacatc  agccagagg  ggcctcaga  cctgaacat  cgccagtca  2340
tatctacct  cagctcaga  aatccatca  atggggagg  aggcacagc  agtgaacct  2400
cccccagtg  cacacctga  gttggcagc  ccaacactg  tgagcggcc  gatgagcgg  2460
ctgatgaca  gtgctccca  ggctcagaa  tcccactgg  cccacctcc  tcagaggtc  2520
tccctggcc  tgaacccag  tccctgccc  ttccacacc  ggaacttct  agagagcgg  2580
gccctccca  ttctgagga  tcagactgt  acagcactg  attggacaa  tccaacagc  2640
ttgatgcct  gcgcccccc  gcttccctc  ctccatgaa  gccactcgt  ttccttgta  2700
atagagaaa  atttatatg  attatatat  tatacatat  tatatatat  tgcgccaca  2760
aatcaacag  aagatgggg  tgtcccagc  gtaagtcag  ctcgaggga  actgatccc  2820
tgaccaatt  acctgataa  ctctaggga  actggcagc  gtggaaatg  atgaggcac  2880
gccgtagag  tgtggctaa  ggcaagccc  ttcctgccc  accccattc  ttatattca  2940
caagcaaca  ggcaataga  aagccaggg  tgtctttat  ttctttatc  ccaaataat  3000
gggggtggg  ggaggggcg  tgggagggg  aggagagaa  accacttag  ctgcacttt  3060
ctgttccgt  tactctgtt  acacatttt  cacttggga  gagggaggc  aaggctggg  3120
cctcccctc  gaggtttct  aggtggcaa  gtaactcat  tttttgtcc  accatttat  3180
ttctctgcc  aagccctgt  ttaaggccc  gggggaggt  aggagactg  tagcatgtg  3240
tggctcagg  tgaagaacc  gggttctgt  taagtccct  cttttatcc  ggtgcctga  3300
tggggtggg  actgtccta  tgtaacccc  gtgaaaaac  ttgaaaaat  acactccat  3360
cagga  3365



<210> 2110
<211> 859
<212> PRT
<213> Homo sapiens
<308> Q12852
<400> 2110

Met Ala Cys Leu His Glu Thr Arg Thr Pro Ser Pro Ser Phe Gly Gly 
  1               5                  10                  15
Phe Val Ser Thr Leu Ser Glu Ala Ser Met Arg Lys Leu Asp Pro Asp 
             20                  25                  30
Thr Ser Asp Cys Thr Pro Glu Lys Asp Leu Thr Pro Thr His Val Leu 
         35                  40                  45
Gln Leu His Glu Gln Asp Ala Gly Gly Pro Gly Gly Ala Ala Gly Ser 
     50                  55                  60
Pro Glu Ser Arg Ala Ser Arg Val Arg Ala Asp Glu Val Arg Leu Gln 
 65                  70                  75                  80
Cys Gln Ser Gly Ser Gly Phe Leu Glu Gly Leu Phe Gly Cys Leu Arg 
                 85                  90                  95
Pro Val Trp Thr Met Ile Gly Lys Ala Tyr Ser Thr Glu His Lys Gln 
             100                105                110
Gln Gln Glu Asp Leu Trp Glu Val Pro Phe Glu Glu Ile Leu Asp Leu 
         115                120                125
Gln Trp Val Gly Ser Gly Ala Gln Gly Ala Val Phe Leu Gly Arg Phe 
     130                135                140
His Gly Glu Glu Val Ala Val Lys Lys Val Arg Asp Leu Lys Glu Thr 
 145                150                155                160
Asp Ile Lys His Leu Arg Lys Leu Lys His Pro Asn Ile Ile Thr Phe 
                 165                170                175
Lys Gly Val Cys Thr Gln Ala Pro Cys Tyr Cys Ile Leu Met Glu Phe 
             180                185                190
Cys Ala Gln Gly Gln Leu Tyr Glu Val Leu Arg Ala Gly Arg Pro Val 
         195                200                205
Thr Pro Ser Leu Leu Val Asp Trp Ser Met Gly Ile Ala Gly Gly Met 
     210                215                220
Asn Tyr Leu His Leu His Lys Ile Ile His Arg Asp Leu Lys Ser Pro 
 225                230                235                240
Asn Met Leu Ile Thr Tyr Asp Asp Val Val Lys Ile Ser Asp Phe Gly 
                 245                250                255
Thr Ser Lys Glu Leu Ser Asp Lys Ser Thr Lys Met Ser Phe Ala Gly 
             260                265                270
Thr Val Ala Trp Met Ala Pro Glu Val Ile Arg Asn Glu Pro Val Ser 
         275                280                285
Glu Lys Val Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Leu Leu 
     290                295                300
Thr Gly Glu Ile Pro Tyr Lys Asp Val Asp Ser Ser Ala Ile Ile Trp 
 305                310                315                320
Gly Val Gly Ser Asn Ser Leu His Leu Pro Val Pro Ser Ser Cys Pro 
                 325                330                335
Asp Gly Phe Lys Ile Leu Leu Arg Gln Cys Trp Asn Ser Lys Pro Arg 
             340                345                350
Asn Arg Pro Ser Phe Arg Gln Ile Leu Leu His Leu Asp Ile Ala Ser 
         355                360                365
Ala Asp Val Leu Ser Thr Pro Gln Glu Thr Tyr Phe Lys Ser Gln Ala 
     370                375                380
Glu Trp Arg Glu Glu Val Lys Leu His Phe Glu Lys Ile Lys Ser Glu 
 385                390                395                400
Gly Thr Cys Leu His Arg Leu Glu Glu Glu Leu Val Met Arg Arg Arg 
                 405                410                415
Glu Glu Leu Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg Lys 
             420                425                430
Leu Glu Arg Ala Asn Asn Leu Tyr Met Glu Leu Asn Ala Leu Met Leu 
         435                440                445
Gln Leu Glu Leu Lys Glu Arg Glu Leu Leu Arg Arg Glu Gln Ala Leu 
     450                455                460
Glu Arg Arg Cys Pro Gly Leu Leu Lys Pro His Pro Ser Arg Gly Leu 
 465                470                475                480
Leu His Gly Asn Thr Met Glu Lys Leu Ile Lys Lys Arg Asn Val Pro 
                 485                490                495
Gln Asn Leu Ser Pro His Ser Gln Arg Pro Asp Ile Leu Lys Ala Glu 
             500                505                510
Ser Leu Leu Pro Lys Leu Asp Ala Ala Leu Ser Gly Val Gly Leu Pro 
         515                520                525
Gly Cys Pro Lys Ala Pro Pro Ser Pro Gly Arg Ser Arg Arg Gly Lys 
     530                535                540
Thr Arg His Arg Lys Ala Ser Ala Lys Gly Ser Cys Gly Asp Leu Pro 
 545                550                555                560
Gly Leu Arg Thr Ala Val Pro Pro His Glu Pro Gly Gly Pro Gly Ser 
                 565                570                575
Pro Gly Gly Leu Gly Gly Gly Pro Ser Ala Trp Glu Ala Cys Pro Pro 
             580                585                590
Ala Leu Arg Gly Leu His His Asp Leu Leu Leu Arg Lys Met Ser Ser 
         595                600                605
Ser Ser Pro Asp Leu Leu Ser Ala Ala Leu Gly Ser Arg Gly Arg Gly 
     610                615                620
Ala Thr Gly Gly Ala Gly Asp Pro Gly Ser Pro Pro Pro Ala Arg Gly 
 625                630                635                640
Asp Thr Pro Pro Ser Glu Gly Ser Ala Pro Gly Ser Thr Ser Pro Asp 
                 645                650                655
Ser Pro Gly Gly Ala Lys Gly Glu Pro Pro Pro Pro Val Gly Pro Gly 
             660                665                670
Glu Gly Val Gly Leu Leu Gly Thr Gly Arg Glu Gly Thr Ser Gly Arg 
         675                680                685
Gly Gly Ser Arg Ala Gly Ser Gln His Leu Thr Pro Ala Ala Leu Leu 
     690                695                700
Tyr Arg Ala Ala Val Thr Arg Ser Gln Lys Arg Gly Ile Ser Ser Glu 
 705                710                715                720
Glu Glu Glu Gly Glu Val Asp Ser Glu Val Glu Leu Thr Ser Ser Gln 
                 725                730                735
Arg Trp Pro Gln Ser Leu Asn Met Arg Gln Ser Leu Ser Thr Phe Ser 
             740                745                750
Ser Glu Asn Pro Ser Asp Gly Glu Glu Gly Thr Ala Ser Glu Pro Ser 
         755                760                765
Pro Ser Gly Thr Pro Glu Val Gly Ser Thr Asn Thr Asp Glu Arg Pro 
     770                775                780
Asp Glu Arg Ser Asp Asp Met Cys Ser Gln Gly Ser Glu Ile Pro Leu 
 785                790                795                800
Asp Pro Pro Pro Ser Glu Val Ile Pro Gly Pro Glu Pro Ser Ser Leu 
                 805                810                815
Pro Ile Pro His Gln Glu Leu Leu Arg Glu Arg Gly Pro Pro Asn Ser 
             820                825                830
Glu Asp Ser Asp Cys Asp Ser Thr Glu Leu Asp Asn Ser Asn Ser Val 
         835                840                845
Asp Ala Leu Arg Pro Pro Ala Ser Leu Pro Pro 
     850                855



<210> 2111
<211> 1739
<212> DNA
<213> Rattus norvegicus
<308> D49847
<400> 2111

ggaggacgg  acgtcgcgg  tggcattgt  tgtcccagt  tgcaagaat  gccccagaa  60
aggaaaggc  gagcccaga  cgcttcagc  gggaagatt  ccttccccc  gcttcaggc  120
gctgagcac  gagcggcgc  cagaatgga  gccatcgcc  aatatgact  caaagctac  180
gctgacgat  agctgagct  caagagggg  gacatcctt  aggttttga  tgaagagtg  240
gatcagaac  ggtataagg  agaactcaa  gggaaagat  gcttcatcc  caagaatta  300
atagaaatg  aaccacatc  gtaagtcag  ctctatggt  cccctaagc  aggggtttg  360
ctgcttgtc  ccagcactg  tttgatttg  ttttggggg  atgatgtag  aggctcttc  420
ctatatagg  cttgttccc  taagctgta  ccagcctgt  gaccaggct  gcctcacag  480
gacccacct  cctctgcct  cctactgtt  cagcatgcc  agattggtt  ggttttgtg  540
gataggctt  aaagtctta  taaagacat  aaaatcaaa  taataatat  gaagaaatc  600
aaatcaatt  aaatggcaa  tatatgtta  attactgga  ctctgtcct  ggttcagaa  660
gccccttgc  tgcgatctc  gcagcctaa  attgggagc  agcgtacag  cagtccagg  720
tactcagag  cagactcga  tggggataa  tccgaagaa  ctttgagac  ccaagcatg  780
agtcctcac  gcttcctgt  gtgggataa  cccacttgg  actcctaca  ccatttagc  840
ttgggtttt  tgtctttta  gtatttttt  ctttaggga  ttttgtggg  ttttcacag  900
caaaacagt  atacgctgg  ggagaagca  gaagcagtg  ggatgaccc  tagatcaga  960
ctagactca  cctgtgcat  tcaccaaga  tccctacgc  tctgtctcc  tcatccatg  1020
tcaaaaagc  tctgtgccg  atggtatca  agaccgtgt  ggtcccagc  cctaggagg  1080
agaggcagg  gatccctgg  agtcgggac  agcctggtc  gtagtattg  gattagcca  1140
gactgcatg  tgagaccct  tcttaaaga  aagaaagaa  ggatggagg  aagcaagga  1200
ggagaatat  aaagtgtac  tgggaaaac  caggctgga  aggtggctt  gtggttagg  1260
gcattgtct  ctcttccat  gaatttggg  ttgagtcct  gcaccaaca  catggctca  1320
agccatctg  aatttaagt  ctagagacc  aagtcctct  ctggccacc  aagtcacag  1380
catacatgc  ggcataaca  tcatgtata  actttttat  ttttaaata  gaaagaaaa  1440
cagaaggtc  ggagacagt  tgtaaagga  gaagttttc  ttctttctc  ccctttgtt  1500
atttcttac  tggtcaagg  cttactata  ggctctgac  agaactttt  ttgaccact  1560
tggccttaa  ctcaaagat  tgcctgcct  tgcctctgc  tctgccttc  aagtgtgtg  1620
attattaaa  gtccatgcc  acacacatg  cctgccttc  tttaaaaag  aaattgtgg  1680
ggttgggga  ttagctcag  ggtagagcg  ttgggccct  ggttcagtc  ccagctccc  1739



<210> 2112
<211> 217
<212> PRT
<213> Rattus norvegicus
<308> P29354
<400> 2112

Met Glu Ala Ile Ala Lys Tyr Asp Phe Lys Ala Thr Ala Asp Asp Glu 
  1               5                  10                  15
Leu Ser Phe Lys Arg Gly Asp Ile Leu Lys Val Leu Asn Glu Glu Cys 
             20                  25                  30
Asp Gln Asn Trp Tyr Lys Ala Glu Leu Asn Gly Lys Asp Gly Phe Ile 
         35                  40                  45
Pro Lys Asn Tyr Ile Glu Met Lys Pro His Pro Trp Phe Phe Gly Lys 
     50                  55                  60
Ile Pro Arg Ala Lys Ala Glu Glu Met Leu Ser Lys Gln Arg His Asp 
 65                  70                  75                  80
Gly Ala Phe Leu Ile Arg Glu Ser Glu Ser Ala Pro Gly Asp Phe Ser 
                 85                  90                  95
Leu Ser Val Lys Phe Gly Asn Asp Val Gln His Phe Lys Val Leu Arg 
             100                105                110
Asp Gly Ala Gly Lys Tyr Phe Leu Trp Val Val Lys Phe Asn Ser Leu 
         115                120                125
Asn Glu Leu Val Asp Tyr His Arg Ser Thr Ser Val Ser Arg Asn Gln 
     130                135                140
Gln Ile Phe Leu Arg Asp Ile Glu Gln Val Pro Gln Gln Pro Thr Tyr 
 145                150                155                160
Val Gln Ala Leu Phe Asp Phe Asp Pro Gln Glu Asp Gly Glu Leu Gly 
                 165                170                175
Phe Arg Arg Gly Asp Phe Ile His Val Met Asp Asn Ser Asp Pro Asn 
             180                185                190
Trp Trp Lys Gly Ala Cys His Gly Gln Thr Gly Met Phe Pro Arg Asn 
         195                200                205
Tyr Val Thr Pro Val Asn Arg Asn Val 
     210                215



<210> 2113
<211> 1356
<212> DNA
<213> Homo sapiens
<308> BC000631
<400> 2113

ggcacgagg  accgggcgg  ggcagcggc  gcggcggct  tggcagagt  tgtgcctgt  60
gcggtgacg  cggcgggag  aagcgctgc  ctcgcagag  agccttggg  tcgccggcc  120
ctcgcagcg  tgtggaggg  cgggccgga  gctgagcgg  gcagctgcg  cacgggtgg  180
attgtgtgt  ccagagtgc  ggagcgagt  ccagaagag  ggcgaggct  agcccagag  240
gctgggttg  ttcagcagg  aagactccc  tccccctgc  tcaggctgc  gagcactga  300
cagcgctca  aatggaagc  atcgccaaa  atgacttca  agctactgc  gacgacgag  360
tgagcttca  aagggggga  atcctcaag  ttttgaacg  agaatgtga  cagaactgg  420
acaaggcag  gcttaatgg  aaagacggc  tcattccca  gaactacat  gaaatgaaa  480
cacatccgt  gttttttgg  aaaatcccc  gagccaagg  agaagaaat  cttagcaaa  540
agcggcacg  tggggcctt  cttatccga  agagtgaga  cgctcctgg  gacttctcc  600
tctctgtca  gtttggaaa  gatgtgcag  acttcaagg  gctccgaga  ggagccggg  660
agtacttcc  ctgggtggt  aagttcaat  ctttgaatg  gctggtgga  tatcacaga  720
ctacatctg  ctccagaaa  cagcagata  tcctgcggg  catagaaca  gtgccacag  780
agccgacat  cgtccaggc  ctctttgac  ttgatcccc  ggaggatgg  gagctgggc  840
tccgccggg  agattttat  catgtcatg  ataactcag  ccccaactg  tggaaagga  900
cttgccacg  gcagaccgg  atgtttccc  gcaattatg  cacccccgt  aaccggaac  960
tctaagagt  aagaagcaa  tatttaaag  aagtgaaaa  tgtaaaaca  atacaaaag  1020
attaaaccc  caagctgcc  ctgacagca  cctgtgagg  agtgcagaa  acctggccg  1080
gtcaccctg  gaccctctc  ctttggttg  aactttagg  ggtgggagg  ggcgttgga  1140
ttaaaaatg  caaaactta  ctataaatt  agaagagtt  ttattacaa  ttttcactg  1200
tgctcctct  tcccctcct  tgtcttttt  ttcatcctt  tttctcttc  gtccatcag  1260
gcatgacgt  taaggccac  tatagtcct  gctgacgcc  ataataaaa  acaagaaac  1320
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaa  1356



<210> 2114
<211> 217
<212> PRT
<213> Homo sapiens
<308> P29354
<400> 2114

Met Glu Ala Ile Ala Lys Tyr Asp Phe Lys Ala Thr Ala Asp Asp Glu 
  1               5                  10                  15
Leu Ser Phe Lys Arg Gly Asp Ile Leu Lys Val Leu Asn Glu Glu Cys 
             20                  25                  30
Asp Gln Asn Trp Tyr Lys Ala Glu Leu Asn Gly Lys Asp Gly Phe Ile 
         35                  40                  45
Pro Lys Asn Tyr Ile Glu Met Lys Pro His Pro Trp Phe Phe Gly Lys 
     50                  55                  60
Ile Pro Arg Ala Lys Ala Glu Glu Met Leu Ser Lys Gln Arg His Asp 
 65                  70                  75                  80
Gly Ala Phe Leu Ile Arg Glu Ser Glu Ser Ala Pro Gly Asp Phe Ser 
                 85                  90                  95
Leu Ser Val Lys Phe Gly Asn Asp Val Gln His Phe Lys Val Leu Arg 
             100                105                110
Asp Gly Ala Gly Lys Tyr Phe Leu Trp Val Val Lys Phe Asn Ser Leu 
         115                120                125
Asn Glu Leu Val Asp Tyr His Arg Ser Thr Ser Val Ser Arg Asn Gln 
     130                135                140
Gln Ile Phe Leu Arg Asp Ile Glu Gln Val Pro Gln Gln Pro Thr Tyr 
 145                150                155                160
Val Gln Ala Leu Phe Asp Phe Asp Pro Gln Glu Asp Gly Glu Leu Gly 
                 165                170                175
Phe Arg Arg Gly Asp Phe Ile His Val Met Asp Asn Ser Asp Pro Asn 
             180                185                190
Trp Trp Lys Gly Ala Cys His Gly Gln Thr Gly Met Phe Pro Arg Asn 
         195                200                205
Tyr Val Thr Pro Val Asn Arg Asn Val 
     210                215



<210> 2115
<211> 3090
<212> DNA
<213> Rattus norvegicus
<308> D50093
<400> 2115

agtcctcgc  ccagggctt  ctgagtcag  tatcttcaa  tctttgctc  tgatgcagc  60
actcaggag  cttcctgac  agaccctga  tcaggccct  gtggtgtgg  gtggtgtgg  120
gtggtgtgg  gtggtgtgg  gtggtgtgg  gtgttactc  ggacgggtg  gttcacaga  180
ccacacagc  gccccgcag  tgacttttt  aattctggt  agtgaggtc  acatctgtg  240
ataaaggtt  tcctccatg  atggctcag  ccccacagg  ccctggctc  attagagca  300
ccttctgag  atggctcaa  accccacaa  accatgtcc  gttccaaat  ccaccgcat  360
gtcgaagct  aaagccatg  cattaactc  aatgtggta  ttcccagac  agatgtagt  420
taccaattg  ggtaattct  gttttcagg  aacagagtg  aacattgtc  aatctgtcc  480
aagaggatg  gaatgagct  tgtacgtct  acttacttt  ctcctaaag  agaagccac  540
ggggtctga  ttcacacat  tgttctgaa  atgtctagg  gcttcagcc  gagtgccgg  600
cactgatgc  ttgttcttc  tttcacaga  cagccatca  ggcgaacct  ggctactgg  660
tgctggccc  ctttgtgac  acatgtact  atgttggcc  ctgcaaaaa  cggccaaag  720
ctggagggt  gaacactgg  ggaagccgg  accctgggc  gggaagccc  ggaggcaac  780
gttacccac  tcagagtgg  ggtacctgg  ggcagcccc  tggtggtgg  tggggacaa  840
ctcatggtg  tggctgggg  caacctcat  gtggtggct  gggtcagcc  catggcggg  900
gctggagtc  aggaggggg  acccataat  agtggaaca  gcccagcaa  ccaaaaacc  960
acctcaagc  tgtggcagg  gctgccgca  ctggggcag  agtgggggg  cttggtggc  1020
acatgttgg  gagtgccat  agcaggccc  tgctccatt  tggcaacga  tgggaggac  1080
gctactacc  agaaaacat  taccgttac  ctaaccaag  gtactacag  ccggtggat  1140
agtacagca  ccagaacaa  ttcgtgcac  actgtgtca  tatcaccat  aagcagcat  1200
cagtcacca  caccaccaa  ggggagaac  tcacggaga  cgacgtgaa  atgatggag  1260
gtgtggtgg  gcagatgtg  gtcacccag  atcagaagg  gtcccaggc  tattacgac  1320
ggagaagat  tagcgccgt  cttttctcc  cccctcctg  gatcctcct  atctccttc  1380
tcatcttcc  gatcgtggg  tgaggaggc  ttcctgctt  ttccttctc  ttctcgtgg  1440
ctaggctgg  ggaggggtt  cccacctgt  gctctttca  ttgaggtgg  gtctcattc  1500
tgcttctct  tgtccccca  aggctaata  ccttggcag  gatgggtct  gggaaatgt  1560
cagtagacc  gatgctatt  gcttcagcg  cctttgatt  agtccatca  gggccaggg  1620
taacaccag  ccagtaaga  tataacacc  aataactgc  ggctagtca  ggctttgtt  1680
tggtctact  agtaaatac  gtgtaaccc  tgaattgta  ccagaggac  tggtgacag  1740
gacacacat  acttagtat  ggcaaaggg  tctatagcc  aagaagcca  tgtgtgggc  1800
tggcaccct  gataacagc  tcccgcctg  gatatctag  gcatccaca  gtggaattc  1860
ttcttttct  acataaacc  tagctgatt  aaggcaaca  gaaaaagaa  caaattatc  1920
tactgacat  gaaagcaaa  tgtgttcat  ccctaggcg  tggaatgat  tttagcctt  1980
gattaaacc  ggagatttt  actctgagg  gaaccagca  tacaaaagc  tggtctcct  2040
tgatgggag  gatggtgaa  ggacaaagg  aagacccct  cgtttcttc  tttctgtct  2100
ataattatc  agagctaga  ttaggtcgt  ccctaagtt  ctgtactcg  atttgaact  2160
gacaacaaa  agacaatct  caaattctc  tgggctgca  aggagagaa  taggctcca  2220
tccaaagtg  aaagagaaa  tctgctagc  ttgtctaag  aaggctaac  tttccttaa  2280
tcgctttgt  tttccccca  cagacatca  aaccctgtg  tcggttcag  ctgcaccgc  2340
ggtgttctg  gtagaatat  taaatataa  ttcaagctt  ggccttcta  tttaaaaca  2400
ctgaagtgt  gaacgcact  gccgttctg  gcagtacta  gtgtgaccc  tgggctttc  2460
atgtgcact  ggttccgta  gattccaaa  tagagccct  gctggtctt  gaatctgca  2520
gtacttcac  ttttctata  ttgtaactt  gcatgtatt  gttttgtca  ataaaaagt  2580
tataaatgt  tgctatctg  ctgacatta  atagaagct  tgatgagca  gtgtggggg  2640
ttttctcct  caatgctcc  ggccctgtg  ttgtcacga  ggtggcttg  gctcatctg  2700
gcctgggag  ggctcattt  acaccctgt  cctgatggg  ctctgataa  gagtcttct  2760
atttccact  actttgcat  ttcccttaa  ttgtactga  tcctgcaga  acacagtag  2820
actccctgg  gagggaggg  agactgggg  gtagggctc  cccactcca  aagaggttt  2880
tctgttttt  gtttttttc  ctgtgaatc  gtggttttg  ctacatata  gactgttca  2940
aagatcccc  ggaactgaa  ttatgaatg  ttgtgagcc  ctgtggggt  tgggacttg  3000
accaggtac  ctgaaagaa  agccactgg  cttaaccac  gagctactg  ttcagctcc  3060
gggagtttg  ttattctga  ttcagattca  3090



<210> 2116
<211> 254
<212> PRT
<213> Rattus norvegicus
<308> BAA08790
<400> 2116

Met Ala Asn Leu Gly Tyr Trp Leu Leu Ala Leu Phe Val Thr Thr Cys 
  1               5                  10                  15
Thr Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn 
             20                  25                  30
Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg 
         35                  40                  45
Tyr Pro Pro Gln Ser Gly Gly Thr Trp Gly Gln Pro His Gly Gly Gly 
     50                  55                  60
Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
 65                  70                  75                  80
Trp Gly Gln Pro His Gly Gly Gly Trp Ser Gln Gly Gly Gly Thr His 
                 85                  90                  95
Asn Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Leu Lys His Val 
             100                105                110
Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr 
         115                120                125
Met Leu Gly Ser Ala Met Ser Arg Pro Met Leu His Phe Gly Asn Asp 
     130                135                140
Trp Glu Asp Arg Tyr Tyr Arg Glu Asn Met Tyr Arg Tyr Pro Asn Gln 
 145                150                155                160
Val Tyr Tyr Arg Pro Val Asp Gln Tyr Ser Asn Gln Asn Asn Phe Val 
                 165                170                175
His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr 
             180                185                190
Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg 
         195                200                205
Val Val Glu Gln Met Cys Val Thr Gln Tyr Gln Lys Glu Ser Gln Ala 
     210                215                220
Tyr Tyr Asp Gly Arg Arg Ser Ser Ala Val Leu Phe Ser Ser Pro Pro 
 225                230                235                240
Val Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly 
                 245                250



<210> 2117
<211> 2413
<212> DNA
<213> Homo sapiens
<308> AY008282
<400> 2117

cgcgagctt  tcctctcct  acgaccgag  cagagcagt  attatggcg  accttggct  60
ctggatgct  gttctcttt  tggccacat  gagtgacct  ggcctctgc  agaagcgcc  120
gaagcctgg  ggatggaac  ctgggggca  ccgataccc  gggcagggc  gccctggag  180
caaccgcta  ccacctcag  gcggtggtg  ctgggggca  cctcatggt  gtggctggg  240
gcagcctca  ggtggtggc  gggggcagc  ccatggtgg  ggctgggga  agcctcatg  300
tggtggctg  ggtcaagga  gtggcaccc  cagtcagtg  aacaagccg  gtaagccaa  360
aaccaacat  aagcacatg  ctggtgctg  agcagctgg  gcagtggtg  ggggccttg  420
cggctacat  ctgggaagt  ccatgagca  gcccatcat  catttcggc  gtgactatg  480
ggaccgtta  tatcgtgaa  acatgcacc  ttaccccaa  caagtgtac  acaggccca  540
ggatgagta  agcaaccag  acaactttg  gcacgactg  gtcaatatc  caatcaagc  600
gcacacggt  accacaacc  ccaaggggg  gaacttcac  gagaccgac  ttaagatga  660
ggagcgcgt  gttgagcag  tgtgtatca  ccagtacga  agggaatct  aggcctatt  720
ccagagagg  tcgagcatg  tcctcttct  ctctccacc  gtgatcctc  tgatctctt  780
cctcatctt  ctgatagtg  gatgaggaa  gtcttcctg  tttcaccat  tttctaatc  840
ttttccagc  tgagggagg  ggtatccac  tgcagccct  ttagtggtg  tgtctcact  900
tttcttctc  ctttgtccc  gataggcta  tcaataccc  tggcactga  gggcactgg  960
aaacataga  tagacctga  atgctggtc  agccccctt  gattgagtt  atcatgagc  1020
gttgctaat  ccaggccag  aaaagtata  cagcaaata  ccattggtt  atctggact  1080
atttttgga  ttagtgcaa  aggttgagg  taaaacaaa  ctcagaaca  tctgaaata  1140
ctttgcctg  atacctctg  ctccttcag  agctagagc  cagtatact  atgccctat  1200
ttagtagag  tttcatagc  atttagaga  attttccat  ttaagaaaa  ccgacaaca  1260
ttctgccag  tttgttagg  ggccacatg  tacttattc  aaaaaatcc  agagattct  1320
agctcttgg  atgcaggct  agcccgctg  agcatgagc  ctgtgtgta  cgagaactg  1380
ggtgatgtt  tacttttca  agtatgggc  acacagcag  tgttcaaca  gagtaaata  1440
tgtcacaac  ctgaacctc  ggctagagg  catattcac  gtgaacata  ctgtaacat  1500
tatgaaagg  ttctgggac  tgaaatcaa  tgtttggga  tggtgccct  ggaggcaac  1560
tcccatttt  gatgtttaa  ggaccctat  tgtggcatt  ctttcttta  actataggt  1620
attaaggca  ctgaaaagt  aattgcctt  tagacactg  aggcaaatc  cctttgtcc  1680
tttacctgg  aaccagaat  attttgaca  acaggagag  tgcagttgt  aaagcacca  1740
catcataga  gatgatgta  ttaaaaaat  gtcagtgtg  aaagaaaag  actgcttgc  1800
tttctttat  tctgtctca  aattgtcaa  aaccagaat  aggtcaagt  catagtttc  1860
gtaattggc  tttgaatca  agaataggg  gacaatcta  aaaatatct  aggttggag  1920
tgacagaaa  atgattgat  tgaagtgga  aaagaaatt  tgttaatgt  aattaaagt  1980
aaattattc  ctgaattgt  tgatattgt  acctagcag  tatgtatta  ttttctgca  2040
tgttattat  ggcttgcac  ttgtgagta  tctatgtaa  aatatatat  tatataaaa  2100
atatattgc  taggacaga  ttaggagtt  tgtttagag  agttaacat  tgaagtgtc  2160
aatgcatta  cttttgtaa  gtactgaat  cttaatatg  gggaaaccc  tttgcgtgg  2220
ccttaggct  acaatgtgc  ctgaatcgt  tcatgtaag  atccaaagt  gacaccatt  2280
acaggtctt  gaaatatgc  tgtacttta  attttctat  tttgtaact  tgcatgttc  2340
tgttttgtt  tataaaaaa  ttgtaaatg  ttaatatct  actgaaatt  aacgagcga  2400
gatgagccc  caa  2413



<210> 2118
<211> 253
<212> PRT
<213> Homo sapiens
<308> P04156
<400> 2118

Met Ala Asn Leu Gly Cys Trp Met Leu Val Leu Phe Val Ala Thr Trp 
  1               5                  10                  15
Ser Asp Leu Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn 
             20                  25                  30
Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg 
         35                  40                  45
Tyr Pro Pro Gln Gly Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
     50                  55                  60
Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
 65                  70                  75                  80
Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Gly Gly Gly Thr His 
                 85                  90                  95
Ser Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Met Lys His Met 
             100                105                110
Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr 
         115                120                125
Met Leu Gly Ser Ala Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp 
     130                135                140
Tyr Glu Asp Arg Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln 
 145                150                155                160
Val Tyr Tyr Arg Pro Met Asp Glu Tyr Ser Asn Gln Asn Asn Phe Val 
                 165                170                175
His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr 
             180                185                190
Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg 
         195                200                205
Val Val Glu Gln Met Cys Ile Thr Gln Tyr Glu Arg Glu Ser Gln Ala 
     210                215                220
Tyr Tyr Gln Arg Gly Ser Ser Met Val Leu Phe Ser Ser Pro Pro Val 
 225                230                235                240
Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly 
                 245                250



<210> 2119
<211> 838
<212> DNA
<213> Rattus norvegicus
<308> D50436
<400> 2119

gggacccag  ggacccttg  cactgcgca  gaccccgcg  gacccggaa  cttccgaca  60
ggttatggc  gccgctccg  gcgcccgac  cctgcgcgc  gcctgcgcc  ccgtcgctt  120
tcgtggtct  gactgccgt  ggctgctgg  ctgcgggac  cgtgcggga  ctgccgtcc  180
tcagtggac  ccgagcccc  acacgcttg  agaggccgg  cctggccgg  cactgagcg  240
gtctgcgcg  gcgcggagt  gctcagaag  taaggtaac  gtccacttc  agaaccgag  300
tggtgaaac  ctaacgacc  aggggaaag  tggtgactc  ctgctagat  ttgtgattg  360
gaataacct  gatatcgat  gatttggtg  gtgtgaggg  actttggct  gctctacct  420
tcatcttat  tttgaggac  atatatatg  gaagttaga  gccattact  atgaagaga  480
cgacatgct  gacctggct  ttggactaa  aaacaggtc  cggctgggc  gtcaagttt  540
tctgaccaa  gctatggac  atatgactg  ccgtgtgcc  gaagcagtg  cagatgtcc  600
acagtctgt  gacatgagc  agaattcct  agctacaat  aaaagaata  tttcattaa  660
tttttacct  tttttataa  tatttctta  cataattga  tatatggcc  aaatatgta  720
ctgtgctgt  ttagttcag  tttgtagta  tgaaaattt  cagttttta  tttgattaa  780
ttattaaaa  atcagtcta  tagaagaca  ctgatacaa  aaactcctt  tgtatttt  838



<210> 2120
<211> 188
<212> PRT
<213> Rattus norvegicus
<308> P24483
<400> 2120

Met Ala Ala Ala Pro Gly Ala Arg Leu Leu Arg Ala Ala Cys Ala Ser 
  1               5                  10                  15
Val Ala Phe Arg Gly Leu Asp Cys Arg Arg Leu Leu Val Cys Gly Thr 
             20                  25                  30
Arg Ala Gly Pro Ala Val Pro Gln Trp Thr Pro Ser Pro His Thr Leu 
         35                  40                  45
Ala Glu Ala Gly Pro Gly Arg Pro Leu Ser Val Ser Ala Arg Ala Arg 
     50                  55                  60
Ser Ser Ser Glu Asp Lys Val Thr Val His Phe Lys Asn Arg Asp Gly 
 65                  70                  75                  80
Glu Thr Leu Thr Thr Lys Gly Lys Val Gly Asp Ser Leu Leu Asp Val 
                 85                  90                  95
Val Ile Glu Asn Asn Leu Asp Ile Asp Gly Phe Gly Ala Cys Glu Gly 
             100                105                110
Thr Leu Ala Cys Ser Thr Cys His Leu Ile Phe Glu Asp His Ile Tyr 
         115                120                125
Glu Lys Leu Asp Ala Ile Thr Asp Glu Glu Asn Asp Met Leu Asp Leu 
     130                135                140
Ala Phe Gly Leu Thr Asn Arg Ser Arg Leu Gly Cys Gln Val Cys Leu 
 145                150                155                160
Thr Lys Ala Met Asp Asn Met Thr Val Arg Val Pro Glu Ala Val Ala 
                 165                170                175
Asp Val Arg Gln Ser Val Asp Met Ser Lys Asn Ser 
             180                185



<210> 2121
<211> 827
<212> DNA
<213> Homo sapiens
<308> M18003
<400> 2121

cgggccggc  gttcccgac  gcgggcgat  gctgccgct  ggggcgccc  gctgctgcg  60
gccgcttct  ctgtcctcg  cggcccggc  ggccggtgg  tgcaccacg  tgggtcccg  120
gctggatcc  gcggcctgc  gaggaaccg  gggccgggc  ggagcgcgg  ggcgagccg  180
tcgctgagc  tgtcggcgc  ggcccggag  agctcagaa  ataaaataa  agtccactt  240
ataaaccgt  atggtgaaa  attaacaac  aaaggaaaa  ttggtgatt  tctgctaga  300
gttgtggtt  aaaataatc  agatattga  ggctttggt  catgtgagg  aaccctggc  360
tgttcaacc  gtcacctca  ctttgaaga  cacatatat  agaagttag  tgcaatcac  420
gatgaggag  atgacatgc  cgatctggc  tatggacta  cagacagat  acggttggg  480
tgccaaatc  gtttgacaa  atctatgga  aatatgact  ttcgagtgc  tgaaacagt  540
gctgatgcc  gacaatcca  tgatgtggg  aagacctcc  gaactagaa  aaataggaa  600
attttcatg  aattttacc  atttttata  ttattattt  ttaaagtga  taaatgaga  660
catggatga  tggacttca  attatgact  gctttacta  tttaattca  cttgcataa  720
tactgaatt  tgtcattct  gaaagtatg  aatttttat  ttggttata  tacaaaaat  780
tcaatcaaa  attaaaaaa  agttaatgt  atagaaaaa  cttacat  827



<210> 2122
<211> 184
<212> PRT
<213> Homo sapiens
<308> P10109
<400> 2122

Met Ala Ala Ala Gly Gly Ala Arg Leu Leu Arg Ala Ala Ser Ala Val 
  1               5                  10                  15
Leu Gly Gly Pro Ala Gly Arg Trp Leu His His Ala Gly Ser Arg Ala 
             20                  25                  30
Gly Ser Ser Gly Leu Leu Arg Asn Arg Gly Pro Gly Gly Ser Ala Glu 
         35                  40                  45
Ala Ser Arg Ser Leu Ser Val Ser Ala Arg Ala Arg Ser Ser Ser Glu 
     50                  55                  60
Asp Lys Ile Thr Val His Phe Ile Asn Arg Asp Gly Glu Thr Leu Thr 
 65                  70                  75                  80
Thr Lys Gly Lys Val Gly Asp Ser Leu Leu Asp Val Val Val Glu Asn 
                 85                  90                  95
Asn Leu Asp Ile Asp Gly Phe Gly Ala Cys Glu Gly Thr Leu Ala Cys 
             100                105                110
Ser Thr Cys His Leu Ile Phe Glu Asp His Ile Tyr Glu Lys Leu Asp 
         115                120                125
Ala Ile Thr Asp Glu Glu Asn Asp Met Leu Asp Leu Ala Tyr Gly Leu 
     130                135                140
Thr Asp Arg Ser Arg Leu Gly Cys Gln Ile Cys Leu Thr Lys Ser Met 
 145                150                155                160
Asp Asn Met Thr Val Arg Val Pro Glu Thr Val Ala Asp Ala Arg Gln 
                 165                170                175
Ser Ile Asp Val Gly Lys Thr Ser 
             180



<210> 2123
<211> 1786
<212> DNA
<213> Rattus norvegicus
<308> D63761
<400> 2123

cggcgggtt  ctcttctca  ccatggctc  tcgctgctg  cgctggtgg  gctggtccg  60
gtggcctgg  gttcggccg  ttccctcca  gagcactcc  acccctggc  tctgcaaga  120
gttctccac  caggagaca  cccctcaga  ctgtgtggt  ggcagtggc  cagctggct  180
ctacacagc  caacacttg  tgaagcacc  cacccgggc  cacgtagac  tctatgaga  240
gcagctcgt  cccttcggc  tggtgcgct  tggtgtggc  cctgaccat  ctgaagtaa  300
gaatgtcat  aacacattt  cacagacag  ccgctcaga  cgctgtgcc  tccggggca  360
tgtggtggt  ggcagggac  tgtccgttc  agagcttcg  gaagcctac  atgctgtgg  420
tctgagtta  ggagccgag  accaccaac  cctggaaat  cctggcgag  agctgcctg  480
agtggtctc  gcccgggcc  ttgtgggct  gtacaatgg  cttcctgag  accagaagc  540
ggctccgga  ctgagctgt  acacggctg  gattctggg  caagggaat  tggctctgg  600
tgtggcccg  atcctgctg  ccccacctg  gcacctgga  aaaacagac  tcacagagg  660
tgcactggg  gtcctgagg  agagtcggg  gaagactgt  tggatagtg  gtcggcgtg  720
acccctgca  gtagccttc  ccattaagg  gcttcggga  atgattcag  tgccaggaa  780
ccagcccat  ttggatcct  cggatttct  gggcctcca  gacagaatt  aggatgtcc  840
ccgtccaag  aaacggctg  cagagctgc  gcttcggac  gccacggag  agccaggag  900
ggaagaggc  gcccgccgg  cactggcct  tcgggcctg  ggcctccgc  ttttccgaa  960
cccccagca  gtgctaccc  ccccagatg  tcgacgggt  gcaggcatc  gcctggcag  1020
taccagact  gagggtgtt  gtgagtcca  acgggcagt  cccacggga  atgtggagg  1080
cctcccttg  gggctgctg  tgagcagtg  tgggtataa  agccgtccc  tcgacccca  1140
cgtgccctt  gaccccaag  ttggaatca  ccccaacac  gagggccgg  ttgtgaatg  1200
accaggcct  tactgcagt  gctgggtga  gaggggacc  acaggtgtc  tcaccacaa  1260
catgacaga  agcttcctc  ccagccagg  gctgctgaa  gacctgaag  ccgggctgc  1320
gccctctgg  cccagacct  gctatacag  cattcaagc  ctgctcagt  atcgagggg  1380
ccggccagt  tctttctca  attgggaga  gttggatgc  gaggaagta  ctcgaggcc  1440
gggcactgg  aaaccaagg  agaagctgg  ggatcgaag  gagatgctg  agctgctgg  1500
gcactgaac  tgggcccca  accccaccg  acaagaaga  ctgtgctgg  ttggcagtt  1560
ggttacagt  ctgactgtc  tggcttgga  gccgacctg  ggcctttcc  gggccctct  1620
agctctgcc  cagttaacc  cccagtgtg  gtttaggcc  aggagggaa  ctgagctag  1680
gatggatgg  ggtacggac  gaccctacc  atcttgttt  cttcctgtc  gacgatggt  1740
ggcctctag  ctggaacac  gtggaaata  aacagacgt  cctaag  1786



<210> 2124
<211> 494
<212> PRT
<213> Rattus norvegicus
<308> P56522
<400> 2124

Met Ala Pro Arg Cys Trp Arg Trp Trp Ser Trp Ser Ala Trp Pro Gly 
  1               5                  10                  15
Val Arg Pro Leu Pro Ser Arg Ser Thr Pro Thr Pro Gly Phe Cys Lys 
             20                  25                  30
Lys Phe Ser Thr Gln Glu Thr Thr Pro Gln Ile Cys Val Val Gly Ser 
         35                  40                  45
Gly Pro Ala Gly Phe Tyr Thr Ala Gln His Leu Leu Lys His His Thr 
     50                  55                  60
Arg Ala His Val Asp Ile Tyr Glu Lys Gln Leu Val Pro Phe Gly Leu 
 65                  70                  75                  80
Val Arg Phe Gly Val Ala Pro Asp His Pro Glu Val Lys Asn Val Ile 
                 85                  90                  95
Asn Thr Phe Thr Gln Thr Ala Arg Ser Asp Arg Cys Ala Phe Arg Gly 
             100                105                110
Asn Val Val Val Gly Arg Asp Val Ser Val Pro Glu Leu Arg Glu Ala 
         115                120                125
Tyr His Ala Val Val Leu Ser Tyr Gly Ala Glu Asp His Gln Pro Leu 
     130                135                140
Glu Ile Pro Gly Glu Glu Leu Pro Gly Val Val Ser Ala Arg Ala Phe 
 145                150                155                160
Val Gly Trp Tyr Asn Gly Leu Pro Glu Asn Gln Lys Leu Ala Pro Asp 
                 165                170                175
Leu Ser Cys Asp Thr Ala Val Ile Leu Gly Gln Gly Asn Val Ala Leu 
             180                185                190
Asp Val Ala Arg Ile Leu Leu Thr Pro Pro Glu His Leu Glu Lys Thr 
         195                200                205
Asp Ile Thr Glu Val Ala Leu Gly Val Leu Arg Gln Ser Arg Val Lys 
     210                215                220
Thr Val Trp Ile Val Gly Arg Arg Gly Pro Leu Gln Val Ala Phe Thr 
 225                230                235                240
Ile Lys Glu Leu Arg Glu Met Ile Gln Leu Pro Gly Thr Gln Pro Ile 
                 245                250                255
Leu Asp Pro Ser Asp Phe Leu Gly Leu Gln Asp Arg Ile Lys Asp Val 
             260                265                270
Pro Arg Pro Arg Lys Arg Leu Thr Glu Leu Leu Leu Arg Thr Ala Thr 
         275                280                285
Glu Lys Pro Gly Val Glu Glu Ala Ala Arg Arg Ala Leu Ala Ser Arg 
     290                295                300
Ala Trp Gly Leu Arg Phe Phe Arg Ser Pro Gln Gln Val Leu Pro Thr 
 305                310                315                320
Pro Asp Gly Arg Arg Val Ala Gly Ile Arg Leu Ala Val Thr Arg Leu 
                 325                330                335
Glu Gly Val Gly Glu Ser Thr Arg Ala Val Pro Thr Gly Asp Val Glu 
             340                345                350
Asp Leu Pro Cys Gly Leu Leu Leu Ser Ser Val Gly Tyr Lys Ser Arg 
         355                360                365
Pro Ile Asp Pro Ser Val Pro Phe Asp Pro Lys Leu Gly Ile Ile Pro 
     370                375                380
Asn Thr Glu Gly Arg Val Val Asn Ala Pro Gly Leu Tyr Cys Ser Gly 
 385                390                395                400
Trp Val Lys Arg Gly Pro Thr Gly Val Ile Thr Thr Thr Met Thr Asp 
                 405                410                415
Ser Phe Leu Thr Ser Gln Val Leu Leu Lys Asp Leu Lys Ala Gly Leu 
             420                425                430
Leu Pro Ser Gly Pro Arg Pro Gly Tyr Thr Ala Ile Gln Ala Leu Leu 
         435                440                445
Ser Asp Arg Gly Val Arg Pro Val Ser Phe Ser Asp Trp Glu Lys Leu 
     450                455                460
Asp Ala Glu Glu Val Ala Arg Gly Gln Gly Thr Gly Lys Pro Arg Glu 
 465                470                475                480
Lys Leu Val Asp Arg Arg Glu Met Leu Gln Leu Leu Gly His 
                 485                490



<210> 2125
<211> 1830
<212> DNA
<213> Homo sapiens
<308> J03826
<400> 2125

gggggttgc  gctcccagc  atggcttcg  gctgctggc  ctggtgggg  tggtcggcg  60
ggcctcgga  ccggctgcc  cccgccggg  gcaccccga  cttctgcca  catttctcc  120
cacaggaga  gacccccca  atctgtgtg  tgggcagtg  cccagctgg  ttctacacg  180
cccaacacc  gctaaagca  ccccaggcc  acgtggaca  ctacgagaa  cagcctgtg  240
cctttggcc  ggtgcgctt  ggtgtggcg  ctgatcacc  cgaggtgaa  aatgtcatc  300
acacattta  ccagacggc  cattctggc  gctgtgcct  ctggggcaa  gtggaggtg  360
gcagggacg  gacggtgcc  gagctgcag  aggcctacc  cgctgtggt  ctgagctac  420
gggcagagg  ccatcgggc  ctggaaatt  ctggtgagg  gctgccagg  gtgtgctcc  480
cccgggcct  cgtgggctg  tacaacggg  ttcctgaga  ccaggagct  gagccagac  540
tgagctgtg  cacagccgt  attctgggg  aggggaacg  ggctctgga  gtggcccgc  600
tcctactga  cccacctga  cacctggag  ccctccttt  gtgccagag  acggacatc  660
cgaaggcag  cctgggtgt  ctgaggcag  gtcgagtga  gacagtgtg  ctagtgggc  720
ggcgtggac  cctgcaagt  gccttcacc  ttaaggagc  tcgggagat  attcagtta  780
cgggagccc  gcccatttt  gatcctgtg  atttcttgg  tctccagga  aagatcaag  840
aggtccccc  cccgaggaa  cggctgacg  aactgctgc  tcgaacggc  acagagaag  900
cagggccgg  ggaagctgc  cgccaggca  cggcctccc  tgcctgggg  ctccgcttt  960
tccgaagcc  ccagcaggt  ctgccctca  cagatgggc  gcgggcagc  ggtgtccgc  1020
tagcagtca  tagactgga  ggtgtcgat  aggccaccc  tgcagtgcc  acgggagac  1080
tggaagacc  cccttgtgg  ctggtgctc  gcagcattg  gtataagag  cgccctgtc  1140
acccaagcg  gccctttga  tccaagctt  gggtcatcc  caatgtgga  ggccgggtt  1200
tggatgtgc  aggcctcta  tgcagcggc  gggtgaaga  aggacctac  ggtgtcata  1260
ccacaacca  gactgacag  ttcctcacc  gccagatgc  gctgcagga  ctgaaggct  1320
ggttgctcc  ctctggccc  aggcctggc  acgcagcca  ccaggccct  ctcagcagc  1380
gaggggtcc  gccagtctc  ttctcagac  gggagaagc  ggatgccga  gaggtggcc  1440
ggggccagg  cacggggaa  cccagggag  agctggtgg  tcctcagga  atgctgcgc  1500
tcctgggcc  ctgagccca  ccccagccc  ggcccccag  agggaaggg  tgagtgttg  1560
gaggggaag  gctgggtcc  tctgagtgg  actttgcac  tctgctgat  ccggccggc  1620
ctggcttgg  ggcttggct  ctcttccag  gtctctcct  cctcctggg  aaggtcgcc  1680
ttgcgcgca  ggttttagc  ttcagcaac  gaggtaacc  tagggacag  tggaggtgt  1740
ggccgatct  accccttac  catctctct  ctgctggac  gtggagggt  accaggttg  1800
gaacatgct  gaaataaaa  agctgcaccc  1830



<210> 2126
<211> 491
<212> PRT
<213> Homo sapiens
<308> P22570
<400> 2126

Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg 
  1               5                  10                  15
Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Ser Phe Cys His His Phe 
             20                  25                  30
Ser Thr Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro 
         35                  40                  45
Ala Gly Phe Tyr Thr Ala Gln His Leu Leu Lys His Pro Gln Ala His 
     50                  55                  60
Val Asp Ile Tyr Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe 
 65                  70                  75                  80
Gly Val Ala Pro Asp His Pro Glu Val Lys Asn Val Ile Asn Thr Phe 
                 85                  90                  95
Thr Gln Thr Ala His Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu 
             100                105                110
Val Gly Arg Asp Val Thr Val Pro Glu Leu Gln Glu Ala Tyr His Ala 
         115                120                125
Val Val Leu Ser Tyr Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro 
     130                135                140
Gly Glu Glu Leu Pro Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp 
 145                150                155                160
Tyr Asn Gly Leu Pro Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys 
                 165                170                175
Asp Thr Ala Val Ile Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala 
             180                185                190
Arg Ile Leu Leu Thr Pro Pro Glu His Leu Glu Arg Thr Asp Ile Thr 
         195                200                205
Lys Ala Ala Leu Gly Val Leu Arg Gln Ser Arg Val Lys Thr Val Trp 
     210                215                220
Leu Val Gly Arg Arg Gly Pro Leu Gln Val Ala Phe Thr Ile Lys Glu 
 225                230                235                240
Leu Arg Glu Met Ile Gln Leu Pro Gly Ala Arg Pro Ile Leu Asp Pro 
                 245                250                255
Val Asp Phe Leu Gly Leu Gln Asp Lys Ile Lys Glu Val Pro Arg Pro 
             260                265                270
Arg Lys Arg Leu Thr Glu Leu Leu Leu Arg Thr Ala Thr Glu Lys Pro 
         275                280                285
Gly Pro Ala Glu Ala Ala Arg Gln Ala Ser Ala Ser Arg Ala Trp Gly 
     290                295                300
Leu Arg Phe Phe Arg Ser Pro Gln Gln Val Leu Pro Ser Pro Asp Gly 
 305                310                315                320
Arg Arg Ala Ala Gly Val Arg Leu Ala Val Thr Arg Leu Glu Gly Val 
                 325                330                335
Asp Glu Ala Thr Arg Ala Val Pro Thr Gly Asp Met Glu Asp Leu Pro 
             340                345                350
Cys Gly Leu Val Leu Ser Ser Ile Gly Tyr Lys Ser Arg Pro Val Asp 
         355                360                365
Pro Ser Val Pro Phe Asp Ser Lys Leu Gly Val Ile Pro Asn Val Glu 
     370                375                380
Gly Arg Val Met Asp Val Pro Gly Leu Tyr Cys Ser Gly Trp Val Lys 
 385                390                395                400
Arg Gly Pro Thr Gly Val Ile Ala Thr Thr Met Thr Asp Ser Phe Leu 
                 405                410                415
Thr Gly Gln Met Leu Leu Gln Asp Leu Lys Ala Gly Leu Leu Pro Ser 
             420                425                430
Gly Pro Arg Pro Gly Tyr Ala Ala Ile Gln Ala Leu Leu Ser Ser Arg 
         435                440                445
Gly Val Arg Pro Val Ser Phe Ser Asp Trp Glu Lys Leu Asp Ala Glu 
     450                455                460
Glu Val Ala Arg Gly Gln Gly Thr Gly Lys Pro Arg Glu Lys Leu Val 
 465                470                475                480
Asp Pro Gln Glu Met Leu Arg Leu Leu Gly His 
                 485                490



<210> 2127
<211> 3320
<212> DNA
<213> Rattus norvegicus
<308> D63834
<400> 2127

gaattcggc  cgagctgcg  agtgactgg  cggtcgtgt  ggtgctgca  ccaacgagc  60
cggtggcgg  caagggaca  gagcaggac  cccggctcc  aagaattgc  gcccgcgcc  120
ccgcgtcac  cacactctg  gcgccgcga  atacacata  cgatactag  ttttcgccg  180
atcttggaa  tcatcgaca  ctaagatgc  acctgcgat  ggcgggcca  tggggtaca  240
ccccccaga  ggaggctgg  gctgggcgg  ggtagttgg  gccttcatt  ctattggct  300
ctcctatgc  tttcccaaa  ccatcactg  cttctttaa  gagattgaa  ttatattca  360
tgcaacgac  agtgaagtg  catggatat  gtccatcat  ctggctgtc  tgtatgccg  420
aggtcctat  agcagtatc  tggtgaata  atatggcag  cgtccagta  tgattgctg  480
tggctgcct  tctggctgt  gcttgattg  agcttcttt  tgtaacacg  tgcaggaac  540
ttacttctg  attggtgtc  ttggaggtc  tgggcttgc  ttcaacttg  acccagctc  600
gactatgat  ggcaagtat  tctacaaga  gcgaccatt  gccaatggc  tggctatgg  660
aggcagccc  gtgttcctc  ctaccctgg  tccacttaa  caggctttc  ttggtattt  720
tggctggag  ggaagcttc  taattcttg  gggcctcct  ctcaactgt  gtgtagctg  780
atccctgat  cgaccaata  ggcctcagc  aggcaaggt  gaaaaactc  agtccaaag  840
gtctctcca  gaagctggg  agtctgatg  aaatacaga  ctcattgga  gaagtccca  900
aggagaaaa  ctgtcagtc  tccaaacag  taataaatt  ctggacttg  ccctgttta  960
ccatagagg  tttttgctg  acctgtctg  aaatgtggt  atgttcttt  ggctcttta  1020
ccctttggt  tttcttagt  attatggta  gagtaagca  ttttccagt  agaagtcag  1080
cttcctcct  tccattttg  cttttgttg  tatggtggc  agaccgtcc  tgggtcttg  1140
agccaacac  aggtggatc  gacctcgag  ccagtactt  tttgctgct  ctgttgttg  1200
gaatggagt  tgccatttg  tggcacctt  gtctacgac  tatgttggg  tctgcatct  1260
cgcgggagt  tttggattt  cctttggtt  gctcagctc  gtattgttt  agacgttga  1320
ggacctcgt  ggaccccag  ggttctcca  tgctgtggg  ttggtgacc  ttgtggaat  1380
ttgtcctgt  ctcctggga  caccacttt  aggccgcct  aatgacatg  atggagact  1440
caaatacac  tactgggct  gtggcgtga  cctcatcat  gcaggcctc  acctcttca  1500
tggtatggg  atcaattat  gacttgtgg  caaagaaca  aaagcggag  aaaagaaga  1560
ggacggtaa  gaggacgag  ccagcactg  tgttgatga  aagcccaag  agacaatga  1620
agaaacaca  tcgccagcg  cactgcaga  cagctctgg  gaccccgcg  aggaggaga  1680
cccagtctg  cctgtggag  atgaagaga  caggtgtga  ccgagacat  cgaaaccat  1740
ctgctggcc  ctagtctac  agtggtgcc  cgtgcagac  gtggacaat  gtgtggaaa  1800
cccaccagg  tgttcattg  tgggatttt  ttttttcac  ccttaccaa  gcctggatt  1860
aaaatatac  ctgctttag  tagggagtg  ttgacaaag  atatgggga  gaagcagtg  1920
tctgtttgt  tgtttgttt  tttgtttgt  tgtttgttt  aatcttagc  tttaacagt  1980
tcatgaaga  tataatatg  gccttaagt  ttagttttt  gaactcttt  gagagcctt  2040
acttttaaa  ccattctgc  gaattcatc  gtttaaaac  tcattttaa  aggaaaaat  2100
acaactagc  tgcttgagg  aactaacct  aatcttgtt  tgttgttgt  gtaatgctt  2160
gtcagacag  cattgttac  ggaacattt  tgaatagaa  tactgctta  aggtcacag  2220
tttataaaa  actgagcta  agtattttt  tagcattat  gttgcctgg  acatctgct  2280
ctaggtata  atttgagaa  tttgaagca  aaaattctg  atcttggca  ttccagcca  2340
agcctgtca  ctgctgggc  cctcttctg  aatgctcac  acagtctag  gctaaggtg  2400
tgccactga  ttgatacct  tgctcctat  cagagacac  gtgtggtta  aagtaattg  2460
ccatttttg  aatcaaatg  aaaaagtta  tattaaaat  tacaaaaca  ttccttaac  2520
cgtctgatt  aatgtaaac  gtatttcaa  catcagctg  attcagcgt  ggttgtccc  2580
aaaccttag  tatggtgtg  tactctggg  atgtgtggg  ttgaggggc  gtgagtgag  2640
tcttggttc  taggattga  ccagggcca  gagcatgcg  agtacatgc  gtacggccg  2700
gccacaacc  acaggcacc  tggagtcct  ctagtccct  agacctttt  tctgatttt  2760
gatagctca  ttatttact  atagtttag  gctgtatgt  agatatcca  tacagggtg  2820
atgtatgcg  tctttgttt  ttacattgt  ttcagtatt  gcaaaaccg  gagggtcag  2880
gtttggcct  agggaagcc  ataaagata  aatagggtg  aagtttgca  actttcagt  2940
agtacccac  tcccgccac  cacaccaga  ttacagggg  acttctatc  tgcttacga  3000
tatttgacg  agtcttacc  ccacatctt  actttcacg  ccctttcac  tacctgaca  3060
gtagaaaaa  gggtttaat  tatggatag  aggaaagat  gaccagatt  gaattacag  3120
gggtttttt  tttttaaac  tgatgtttt  tgaatagag  cagaaaaaa  aagacatat  3180
acactgaat  ggacgatgc  tttaaaata  cattgtaat  acagggtga  tacagattt  3240
caaccttgt  taagaagct  actttttcc  aataaaaca  ttattttat  tttagaaaa  3300
aaaaaaaaa  aaaactcgag  3320



<210> 2128
<211> 494
<212> PRT
<213> Rattus norvegicus
<308> P53987
<400> 2128

Met Pro Pro Ala Ile Gly Gly Pro Val Gly Tyr Thr Pro Pro Asp Gly 
  1               5                  10                  15
Gly Trp Gly Trp Ala Val Val Val Gly Ala Phe Ile Ser Ile Gly Phe 
             20                  25                  30
Ser Tyr Ala Phe Pro Lys Ser Ile Thr Val Phe Phe Lys Glu Ile Glu 
         35                  40                  45
Ile Ile Phe Ser Ala Thr Thr Ser Glu Val Ser Trp Ile Ser Ser Ile 
     50                  55                  60
Met Leu Ala Val Met Tyr Ala Gly Gly Pro Ile Ser Ser Ile Leu Val 
 65                  70                  75                  80
Asn Lys Tyr Gly Ser Arg Pro Val Met Ile Ala Gly Gly Cys Leu Ser 
                 85                  90                  95
Gly Cys Gly Leu Ile Ala Ala Ser Phe Cys Asn Thr Val Gln Glu Leu 
             100                105                110
Tyr Phe Cys Ile Gly Val Ile Gly Gly Leu Gly Leu Ala Phe Asn Leu 
         115                120                125
Asn Pro Ala Leu Thr Met Ile Gly Lys Tyr Phe Tyr Lys Lys Arg Pro 
     130                135                140
Leu Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Ser Thr 
 145                150                155                160
Leu Ala Pro Leu Asn Gln Ala Phe Phe Gly Ile Phe Gly Trp Arg Gly 
                 165                170                175
Ser Phe Leu Ile Leu Gly Gly Leu Leu Leu Asn Cys Cys Val Ala Gly 
             180                185                190
Ser Leu Met Arg Pro Ile Gly Pro Gln Gln Gly Lys Val Glu Lys Leu 
         195                200                205
Lys Ser Lys Glu Ser Leu Gln Glu Ala Gly Lys Ser Asp Ala Asn Thr 
     210                215                220
Asp Leu Ile Gly Gly Ser Pro Lys Gly Glu Lys Leu Ser Val Phe Gln 
 225                230                235                240
Thr Val Asn Lys Phe Leu Asp Leu Ser Leu Phe Thr His Arg Gly Phe 
                 245                250                255
Leu Leu Tyr Leu Ser Gly Asn Val Val Met Phe Phe Gly Leu Phe Thr 
             260                265                270
Pro Leu Val Phe Leu Ser Asn Tyr Gly Lys Ser Lys His Phe Ser Ser 
         275                280                285
Glu Lys Ser Ala Phe Leu Leu Ser Ile Leu Ala Phe Val Asp Met Val 
     290                295                300
Ala Arg Pro Ser Met Gly Leu Ala Ala Asn Thr Arg Trp Ile Arg Pro 
 305                310                315                320
Arg Val Gln Tyr Phe Phe Ala Ala Ser Val Val Ala Asn Gly Val Cys 
                 325                330                335
His Leu Leu Ala Pro Leu Ser Thr Thr Tyr Val Gly Phe Cys Ile Tyr 
             340                345                350
Ala Gly Val Phe Gly Phe Ala Phe Gly Trp Leu Ser Ser Val Leu Phe 
         355                360                365
Glu Thr Leu Met Asp Leu Val Gly Pro Gln Arg Phe Ser Ser Ala Val 
     370                375                380
Gly Leu Val Thr Ile Val Glu Cys Cys Pro Val Leu Leu Gly Pro Pro 
 385                390                395                400
Leu Leu Gly Arg Leu Asn Asp Met Tyr Gly Asp Tyr Lys Tyr Thr Tyr 
                 405                410                415
Trp Ala Cys Gly Val Ile Leu Ile Ile Ala Gly Leu Tyr Leu Phe Ile 
             420                425                430
Gly Met Gly Ile Asn Tyr Arg Leu Val Ala Lys Glu Gln Lys Ala Glu 
         435                440                445
Glu Lys Lys Arg Asp Gly Lys Glu Asp Glu Thr Ser Thr Asp Val Asp 
     450                455                460
Glu Lys Pro Lys Lys Thr Met Lys Glu Thr Gln Ser Pro Ala Pro Leu 
 465                470                475                480
Gln Asn Ser Ser Gly Asp Pro Ala Glu Glu Glu Ser Pro Val 
                 485                490



<210> 2129
<211> 2578
<212> DNA
<213> Homo sapiens
<308> L31801
<400> 2129

tctacactt  aaatgccac  agcagttgg  ggtccagtt  gatacaccc  cccagatgg  60
ggctggggc  gggcagtgg  aattggagc  ttcatttcc  tcggcttct  ttatgcatt  120
cccaaatca  ttactgtct  cttcaaaga  attgaaggt  tattccatg  caccaccag  180
gaagtgtca  ggatatcct  cataatgtt  gctgtcatg  atggtggag  tcctatcag  240
agtatcctg  tgaataaat  tggaagtcg  atagtcatg  ttgttggtg  ctgcttgtc  300
ggctgtggc  tgattgcag  ttctttctg  aacaccgta  agcaactat  cgtctgtat  360
ggagtcatt  gaggtcttg  gcttgcctt  aacttgaat  cagctctga  catgattgg  420
aagtatttc  acaagaggc  accattggc  aacggactg  ccatggcag  cagccctgt  480
ttcctctgt  ctctggccc  cctcaatca  gttttcttc  gtatctttg  atggagagg  540
agctttcta  ttcttgggg  cttgctact  aactgctgt  ttgctggag  cctcatgcg  600
ccaatcggg  ccaagccaa  caaggcagg  aaagataag  ctaaagcat  ccttgagaa  660
gctggaaaa  ctggtgtga  aaaagatct  catgatgca  atacagatc  tattggaag  720
caccctaaa  aagagaaac  atcagtctt  caaacaatt  atcagttcc  ggacttaac  780
ctattcacc  acagaggct  tttgctata  ctctctgga  atgtgatca  gttttttgg  840
ctctttgca  ctttggtgt  tcttagtag  tatgggaag  gtcagcatt  ttctagtga  900
aagtctgcc  tccttcttt  cattctggc  tttgttgac  tggtagccc  accatctat  960
ggacttgta  ccaacacaa  gccaataag  cctcgaatt  agtatttct  tgcggcttc  1020
gttgttgca  atggagtgt  tcatatgct  gcaccttta  ccactacct  tgttggatt  1080
tgtgtctat  cgggattct  tggatttgc  ttcgggtgg  tcagctccg  attgtttga  1140
acattgatg  accttgttg  accccagag  ttctccagc  ctgtgggat  ggtgaccat  1200
gtggaatgc  gtcctgtcc  cctggggcc  ccactttta  gtcggctca  tgacatgta  1260
ggagactac  aatacacat  ctgggcatg  ggcgtcgtc  taattattt  aggtatcta  1320
ctcttcatt  gcatgggca  caattatcg  cttttggca  aagaacaga  agcaaacga  1380
cagaaaaag  aaagtaaag  ggaagagac  agtatagat  ttgctggga  gccaaatga  1440
gttaccaaa  cagcagaat  tccggacca  aaagacaca  aaggagggc  caaggagga  1500
gaaagtcca  tctgaatcc  tggggctga  gggtaaatt  agcagttca  gacccagga  1560
atctgaaaa  attctactg  cctgtaatc  accagtggt  ctcaatgca  atagtagac  1620
tttgtgtgg  aatcatacc  gttgttcat  gatgggatt  ttgtttgac  ccttaccaa  1680
agcctgaat  tgaggaggg  atgattggt  gcaaaggat  ggggaaaga  gtaggttct  1740
ttttgtttt  ttttaatct  agcttttaa  agtgtcata  agattataa  atgtgcctt  1800
agttttagt  tttagaact  tagagagcc  taacttctt  aaccatttt  gctgaattc  1860
tctatttcg  gtgttgtgt  aaaaggaaa  ataacaact  acttgtttg  ggcaaatct  1920
aaatttaaa  ttaatcttg  ttcattgtt  catgtaata  atttcagac  ttttcactg  1980
aagatttat  aacagaaat  ttggttgaa  gttagagat  ttacaaaat  ctgacaaaa  2040
tattttcct  gcatcagta  atttctggc  tatgtttct  ctagctata  atttaggaa  2100
ttcaaagca  aaaactttg  caacatctt  gctgttcta  acacagtgt  cttgtcaac  2160
cctctcagg  accttttct  gggatgctt  ttagaagcc  agtaaagtg  ttaaggttt  2220
ttttcatta  attagctat  tctgctccc  tgttcaaag  tgcattttg  gtgtttata  2280
atcactgcc  tttttgaaa  cacctggta  tatttttct  actggaaaa  ttagtatta  2340
aatctacag  actacatat  tgtgcctcc  tggtaaata  aacacatct  attaaatgt  2400
gacagatat  tcaaacatc  gctgaattc  cttaagttt  tccaaaacc  cagttaaac  2460
gtgaagcta  tggaatttt  ttttcctgg  atttttccc  tttgattca  agtggtccc  2520
tttatatct  cttctagct  agtgctatg  gtgagatat  tgtgtgttt  gtgttttt  2578



<210> 2130
<211> 500
<212> PRT
<213> Homo sapiens
<308> P53985
<400> 2130

Met Pro Pro Ala Val Gly Gly Pro Val Gly Tyr Thr Pro Pro Asp Gly 
  1               5                  10                  15
Gly Trp Gly Trp Ala Val Val Ile Gly Ala Phe Ile Ser Ile Gly Phe 
             20                  25                  30
Ser Tyr Ala Phe Pro Lys Ser Ile Thr Val Phe Phe Lys Glu Ile Glu 
         35                  40                  45
Gly Ile Phe His Ala Thr Thr Ser Glu Val Ser Trp Ile Ser Ser Ile 
     50                  55                  60
Met Leu Ala Val Met Tyr Gly Gly Gly Pro Ile Ser Ser Ile Leu Val 
 65                  70                  75                  80
Asn Lys Tyr Gly Ser Arg Ile Val Met Ile Val Gly Gly Cys Leu Ser 
                 85                  90                  95
Gly Cys Gly Leu Ile Ala Ala Ser Phe Cys Asn Thr Val Gln Gln Leu 
             100                105                110
Tyr Val Cys Ile Gly Val Ile Gly Gly Leu Gly Leu Ala Phe Asn Leu 
         115                120                125
Asn Pro Ala Leu Thr Met Ile Gly Lys Tyr Phe Tyr Lys Arg Arg Pro 
     130                135                140
Leu Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Cys Thr 
 145                150                155                160
Leu Ala Pro Leu Asn Gln Val Phe Phe Gly Ile Phe Gly Trp Arg Gly 
                 165                170                175
Ser Phe Leu Ile Leu Gly Gly Leu Leu Leu Asn Cys Cys Val Ala Gly 
             180                185                190
Ala Leu Met Arg Pro Ile Gly Pro Lys Pro Thr Lys Ala Gly Lys Asp 
         195                200                205
Lys Ser Lys Ala Ser Leu Glu Lys Ala Gly Lys Ser Gly Val Lys Lys 
     210                215                220
Asp Leu His Asp Ala Asn Thr Asp Leu Ile Gly Arg His Pro Lys Gln 
 225                230                235                240
Glu Lys Arg Ser Val Phe Gln Thr Ile Asn Gln Phe Leu Asp Leu Thr 
                 245                250                255
Leu Phe Thr His Arg Gly Phe Leu Leu Tyr Leu Ser Gly Asn Val Ile 
             260                265                270
Met Phe Phe Gly Leu Phe Ala Pro Leu Val Phe Leu Ser Ser Tyr Gly 
         275                280                285
Lys Ser Gln His Tyr Ser Ser Glu Lys Ser Ala Phe Leu Leu Ser Ile 
     290                295                300
Leu Ala Phe Val Asp Met Val Ala Arg Pro Ser Met Gly Leu Val Ala 
 305                310                315                320
Asn Thr Lys Pro Ile Arg Pro Arg Ile Gln Tyr Phe Phe Ala Ala Ser 
                 325                330                335
Val Val Ala Asn Gly Val Cys His Met Leu Ala Pro Leu Ser Thr Thr 
             340                345                350
Tyr Val Gly Phe Cys Val Tyr Ala Gly Phe Phe Gly Phe Ala Phe Gly 
         355                360                365
Trp Leu Ser Ser Val Leu Phe Glu Thr Leu Met Asp Leu Val Gly Pro 
     370                375                380
Gln Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile Val Glu Cys Cys 
 385                390                395                400
Pro Val Leu Leu Gly Pro Pro Leu Leu Gly Arg Leu Asn Asp Met Tyr 
                 405                410                415
Gly Asp Tyr Lys Tyr Thr Tyr Trp Ala Cys Gly Val Val Leu Ile Ile 
             420                425                430
Ser Gly Ile Tyr Leu Phe Ile Gly Met Gly Ile Asn Tyr Arg Leu Leu 
         435                440                445
Ala Lys Glu Gln Lys Ala Asn Glu Gln Lys Lys Glu Ser Lys Glu Glu 
     450                455                460
Glu Thr Ser Ile Asp Val Ala Gly Lys Pro Asn Glu Val Thr Lys Ala 
 465                470                475                480
Ala Glu Ser Pro Asp Gln Lys Asp Thr Glu Gly Gly Pro Lys Glu Glu 
                 485                490                495
Glu Ser Pro Val 
             500



<210> 2131
<211> 3320
<212> DNA
<213> Rattus norvegicus
<308> D63834
<400> 2131

gaattcggc  cgagctgcg  agtgactgg  cggtcgtgt  ggtgctgca  ccaacgagc  60
cggtggcgg  caagggaca  gagcaggac  cccggctcc  aagaattgc  gcccgcgcc  120
ccgcgtcac  cacactctg  gcgccgcga  atacacata  cgatactag  ttttcgccg  180
atcttggaa  tcatcgaca  ctaagatgc  acctgcgat  ggcgggcca  tggggtaca  240
ccccccaga  ggaggctgg  gctgggcgg  ggtagttgg  gccttcatt  ctattggct  300
ctcctatgc  tttcccaaa  ccatcactg  cttctttaa  gagattgaa  ttatattca  360
tgcaacgac  agtgaagtg  catggatat  gtccatcat  ctggctgtc  tgtatgccg  420
aggtcctat  agcagtatc  tggtgaata  atatggcag  cgtccagta  tgattgctg  480
tggctgcct  tctggctgt  gcttgattg  agcttcttt  tgtaacacg  tgcaggaac  540
ttacttctg  attggtgtc  ttggaggtc  tgggcttgc  ttcaacttg  acccagctc  600
gactatgat  ggcaagtat  tctacaaga  gcgaccatt  gccaatggc  tggctatgg  660
aggcagccc  gtgttcctc  ctaccctgg  tccacttaa  caggctttc  ttggtattt  720
tggctggag  ggaagcttc  taattcttg  gggcctcct  ctcaactgt  gtgtagctg  780
atccctgat  cgaccaata  ggcctcagc  aggcaaggt  gaaaaactc  agtccaaag  840
gtctctcca  gaagctggg  agtctgatg  aaatacaga  ctcattgga  gaagtccca  900
aggagaaaa  ctgtcagtc  tccaaacag  taataaatt  ctggacttg  ccctgttta  960
ccatagagg  tttttgctg  acctgtctg  aaatgtggt  atgttcttt  ggctcttta  1020
ccctttggt  tttcttagt  attatggta  gagtaagca  ttttccagt  agaagtcag  1080
cttcctcct  tccattttg  cttttgttg  tatggtggc  agaccgtcc  tgggtcttg  1140
agccaacac  aggtggatc  gacctcgag  ccagtactt  tttgctgct  ctgttgttg  1200
gaatggagt  tgccatttg  tggcacctt  gtctacgac  tatgttggg  tctgcatct  1260
cgcgggagt  tttggattt  cctttggtt  gctcagctc  gtattgttt  agacgttga  1320
ggacctcgt  ggaccccag  ggttctcca  tgctgtggg  ttggtgacc  ttgtggaat  1380
ttgtcctgt  ctcctggga  caccacttt  aggccgcct  aatgacatg  atggagact  1440
caaatacac  tactgggct  gtggcgtga  cctcatcat  gcaggcctc  acctcttca  1500
tggtatggg  atcaattat  gacttgtgg  caaagaaca  aaagcggag  aaaagaaga  1560
ggacggtaa  gaggacgag  ccagcactg  tgttgatga  aagcccaag  agacaatga  1620
agaaacaca  tcgccagcg  cactgcaga  cagctctgg  gaccccgcg  aggaggaga  1680
cccagtctg  cctgtggag  atgaagaga  caggtgtga  ccgagacat  cgaaaccat  1740
ctgctggcc  ctagtctac  agtggtgcc  cgtgcagac  gtggacaat  gtgtggaaa  1800
cccaccagg  tgttcattg  tgggatttt  ttttttcac  ccttaccaa  gcctggatt  1860
aaaatatac  ctgctttag  tagggagtg  ttgacaaag  atatgggga  gaagcagtg  1920
tctgtttgt  tgtttgttt  tttgtttgt  tgtttgttt  aatcttagc  tttaacagt  1980
tcatgaaga  tataatatg  gccttaagt  ttagttttt  gaactcttt  gagagcctt  2040
acttttaaa  ccattctgc  gaattcatc  gtttaaaac  tcattttaa  aggaaaaat  2100
acaactagc  tgcttgagg  aactaacct  aatcttgtt  tgttgttgt  gtaatgctt  2160
gtcagacag  cattgttac  ggaacattt  tgaatagaa  tactgctta  aggtcacag  2220
tttataaaa  actgagcta  agtattttt  tagcattat  gttgcctgg  acatctgct  2280
ctaggtata  atttgagaa  tttgaagca  aaaattctg  atcttggca  ttccagcca  2340
agcctgtca  ctgctgggc  cctcttctg  aatgctcac  acagtctag  gctaaggtg  2400
tgccactga  ttgatacct  tgctcctat  cagagacac  gtgtggtta  aagtaattg  2460
ccatttttg  aatcaaatg  aaaaagtta  tattaaaat  tacaaaaca  ttccttaac  2520
cgtctgatt  aatgtaaac  gtatttcaa  catcagctg  attcagcgt  ggttgtccc  2580
aaaccttag  tatggtgtg  tactctggg  atgtgtggg  ttgaggggc  gtgagtgag  2640
tcttggttc  taggattga  ccagggcca  gagcatgcg  agtacatgc  gtacggccg  2700
gccacaacc  acaggcacc  tggagtcct  ctagtccct  agacctttt  tctgatttt  2760
gatagctca  ttatttact  atagtttag  gctgtatgt  agatatcca  tacagggtg  2820
atgtatgcg  tctttgttt  ttacattgt  ttcagtatt  gcaaaaccg  gagggtcag  2880
gtttggcct  agggaagcc  ataaagata  aatagggtg  aagtttgca  actttcagt  2940
agtacccac  tcccgccac  cacaccaga  ttacagggg  acttctatc  tgcttacga  3000
tatttgacg  agtcttacc  ccacatctt  actttcacg  ccctttcac  tacctgaca  3060
gtagaaaaa  gggtttaat  tatggatag  aggaaagat  gaccagatt  gaattacag  3120
gggtttttt  tttttaaac  tgatgtttt  tgaatagag  cagaaaaaa  aagacatat  3180
acactgaat  ggacgatgc  tttaaaata  cattgtaat  acagggtga  tacagattt  3240
caaccttgt  taagaagct  actttttcc  aataaaaca  ttattttat  tttagaaaa  3300
aaaaaaaaa  aaaactcgag  3320



<210> 2132
<211> 494
<212> PRT
<213> Rattus norvegicus
<308> P53987
<400> 2132

Met Pro Pro Ala Ile Gly Gly Pro Val Gly Tyr Thr Pro Pro Asp Gly 
  1               5                  10                  15
Gly Trp Gly Trp Ala Val Val Val Gly Ala Phe Ile Ser Ile Gly Phe 
             20                  25                  30
Ser Tyr Ala Phe Pro Lys Ser Ile Thr Val Phe Phe Lys Glu Ile Glu 
         35                  40                  45
Ile Ile Phe Ser Ala Thr Thr Ser Glu Val Ser Trp Ile Ser Ser Ile 
     50                  55                  60
Met Leu Ala Val Met Tyr Ala Gly Gly Pro Ile Ser Ser Ile Leu Val 
 65                  70                  75                  80
Asn Lys Tyr Gly Ser Arg Pro Val Met Ile Ala Gly Gly Cys Leu Ser 
                 85                  90                  95
Gly Cys Gly Leu Ile Ala Ala Ser Phe Cys Asn Thr Val Gln Glu Leu 
             100                105                110
Tyr Phe Cys Ile Gly Val Ile Gly Gly Leu Gly Leu Ala Phe Asn Leu 
         115                120                125
Asn Pro Ala Leu Thr Met Ile Gly Lys Tyr Phe Tyr Lys Lys Arg Pro 
     130                135                140
Leu Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Ser Thr 
 145                150                155                160
Leu Ala Pro Leu Asn Gln Ala Phe Phe Gly Ile Phe Gly Trp Arg Gly 
                 165                170                175
Ser Phe Leu Ile Leu Gly Gly Leu Leu Leu Asn Cys Cys Val Ala Gly 
             180                185                190
Ser Leu Met Arg Pro Ile Gly Pro Gln Gln Gly Lys Val Glu Lys Leu 
         195                200                205
Lys Ser Lys Glu Ser Leu Gln Glu Ala Gly Lys Ser Asp Ala Asn Thr 
     210                215                220
Asp Leu Ile Gly Gly Ser Pro Lys Gly Glu Lys Leu Ser Val Phe Gln 
 225                230                235                240
Thr Val Asn Lys Phe Leu Asp Leu Ser Leu Phe Thr His Arg Gly Phe 
                 245                250                255
Leu Leu Tyr Leu Ser Gly Asn Val Val Met Phe Phe Gly Leu Phe Thr 
             260                265                270
Pro Leu Val Phe Leu Ser Asn Tyr Gly Lys Ser Lys His Phe Ser Ser 
         275                280                285
Glu Lys Ser Ala Phe Leu Leu Ser Ile Leu Ala Phe Val Asp Met Val 
     290                295                300
Ala Arg Pro Ser Met Gly Leu Ala Ala Asn Thr Arg Trp Ile Arg Pro 
 305                310                315                320
Arg Val Gln Tyr Phe Phe Ala Ala Ser Val Val Ala Asn Gly Val Cys 
                 325                330                335
His Leu Leu Ala Pro Leu Ser Thr Thr Tyr Val Gly Phe Cys Ile Tyr 
             340                345                350
Ala Gly Val Phe Gly Phe Ala Phe Gly Trp Leu Ser Ser Val Leu Phe 
         355                360                365
Glu Thr Leu Met Asp Leu Val Gly Pro Gln Arg Phe Ser Ser Ala Val 
     370                375                380
Gly Leu Val Thr Ile Val Glu Cys Cys Pro Val Leu Leu Gly Pro Pro 
 385                390                395                400
Leu Leu Gly Arg Leu Asn Asp Met Tyr Gly Asp Tyr Lys Tyr Thr Tyr 
                 405                410                415
Trp Ala Cys Gly Val Ile Leu Ile Ile Ala Gly Leu Tyr Leu Phe Ile 
             420                425                430
Gly Met Gly Ile Asn Tyr Arg Leu Val Ala Lys Glu Gln Lys Ala Glu 
         435                440                445
Glu Lys Lys Arg Asp Gly Lys Glu Asp Glu Thr Ser Thr Asp Val Asp 
     450                455                460
Glu Lys Pro Lys Lys Thr Met Lys Glu Thr Gln Ser Pro Ala Pro Leu 
 465                470                475                480
Gln Asn Ser Ser Gly Asp Pro Ala Glu Glu Glu Ser Pro Val 
                 485                490



<210> 2133
<211> 2578
<212> DNA
<213> Homo sapiens
<308> L31801
<400> 2133

tctacactt  aaatgccac  agcagttgg  ggtccagtt  gatacaccc  cccagatgg  60
ggctggggc  gggcagtgg  aattggagc  ttcatttcc  tcggcttct  ttatgcatt  120
cccaaatca  ttactgtct  cttcaaaga  attgaaggt  tattccatg  caccaccag  180
gaagtgtca  ggatatcct  cataatgtt  gctgtcatg  atggtggag  tcctatcag  240
agtatcctg  tgaataaat  tggaagtcg  atagtcatg  ttgttggtg  ctgcttgtc  300
ggctgtggc  tgattgcag  ttctttctg  aacaccgta  agcaactat  cgtctgtat  360
ggagtcatt  gaggtcttg  gcttgcctt  aacttgaat  cagctctga  catgattgg  420
aagtatttc  acaagaggc  accattggc  aacggactg  ccatggcag  cagccctgt  480
ttcctctgt  ctctggccc  cctcaatca  gttttcttc  gtatctttg  atggagagg  540
agctttcta  ttcttgggg  cttgctact  aactgctgt  ttgctggag  cctcatgcg  600
ccaatcggg  ccaagccaa  caaggcagg  aaagataag  ctaaagcat  ccttgagaa  660
gctggaaaa  ctggtgtga  aaaagatct  catgatgca  atacagatc  tattggaag  720
caccctaaa  aagagaaac  atcagtctt  caaacaatt  atcagttcc  ggacttaac  780
ctattcacc  acagaggct  tttgctata  ctctctgga  atgtgatca  gttttttgg  840
ctctttgca  ctttggtgt  tcttagtag  tatgggaag  gtcagcatt  ttctagtga  900
aagtctgcc  tccttcttt  cattctggc  tttgttgac  tggtagccc  accatctat  960
ggacttgta  ccaacacaa  gccaataag  cctcgaatt  agtatttct  tgcggcttc  1020
gttgttgca  atggagtgt  tcatatgct  gcaccttta  ccactacct  tgttggatt  1080
tgtgtctat  cgggattct  tggatttgc  ttcgggtgg  tcagctccg  attgtttga  1140
acattgatg  accttgttg  accccagag  ttctccagc  ctgtgggat  ggtgaccat  1200
gtggaatgc  gtcctgtcc  cctggggcc  ccactttta  gtcggctca  tgacatgta  1260
ggagactac  aatacacat  ctgggcatg  ggcgtcgtc  taattattt  aggtatcta  1320
ctcttcatt  gcatgggca  caattatcg  cttttggca  aagaacaga  agcaaacga  1380
cagaaaaag  aaagtaaag  ggaagagac  agtatagat  ttgctggga  gccaaatga  1440
gttaccaaa  cagcagaat  tccggacca  aaagacaca  aaggagggc  caaggagga  1500
gaaagtcca  tctgaatcc  tggggctga  gggtaaatt  agcagttca  gacccagga  1560
atctgaaaa  attctactg  cctgtaatc  accagtggt  ctcaatgca  atagtagac  1620
tttgtgtgg  aatcatacc  gttgttcat  gatgggatt  ttgtttgac  ccttaccaa  1680
agcctgaat  tgaggaggg  atgattggt  gcaaaggat  ggggaaaga  gtaggttct  1740
ttttgtttt  ttttaatct  agcttttaa  agtgtcata  agattataa  atgtgcctt  1800
agttttagt  tttagaact  tagagagcc  taacttctt  aaccatttt  gctgaattc  1860
tctatttcg  gtgttgtgt  aaaaggaaa  ataacaact  acttgtttg  ggcaaatct  1920
aaatttaaa  ttaatcttg  ttcattgtt  catgtaata  atttcagac  ttttcactg  1980
aagatttat  aacagaaat  ttggttgaa  gttagagat  ttacaaaat  ctgacaaaa  2040
tattttcct  gcatcagta  atttctggc  tatgtttct  ctagctata  atttaggaa  2100
ttcaaagca  aaaactttg  caacatctt  gctgttcta  acacagtgt  cttgtcaac  2160
cctctcagg  accttttct  gggatgctt  ttagaagcc  agtaaagtg  ttaaggttt  2220
ttttcatta  attagctat  tctgctccc  tgttcaaag  tgcattttg  gtgtttata  2280
atcactgcc  tttttgaaa  cacctggta  tatttttct  actggaaaa  ttagtatta  2340
aatctacag  actacatat  tgtgcctcc  tggtaaata  aacacatct  attaaatgt  2400
gacagatat  tcaaacatc  gctgaattc  cttaagttt  tccaaaacc  cagttaaac  2460
gtgaagcta  tggaatttt  ttttcctgg  atttttccc  tttgattca  agtggtccc  2520
tttatatct  cttctagct  agtgctatg  gtgagatat  tgtgtgttt  gtgttttt  2578



<210> 2134
<211> 500
<212> PRT
<213> Homo sapiens
<308> P53985
<400> 2134

Met Pro Pro Ala Val Gly Gly Pro Val Gly Tyr Thr Pro Pro Asp Gly 
  1               5                  10                  15
Gly Trp Gly Trp Ala Val Val Ile Gly Ala Phe Ile Ser Ile Gly Phe 
             20                  25                  30
Ser Tyr Ala Phe Pro Lys Ser Ile Thr Val Phe Phe Lys Glu Ile Glu 
         35                  40                  45
Gly Ile Phe His Ala Thr Thr Ser Glu Val Ser Trp Ile Ser Ser Ile 
     50                  55                  60
Met Leu Ala Val Met Tyr Gly Gly Gly Pro Ile Ser Ser Ile Leu Val 
 65                  70                  75                  80
Asn Lys Tyr Gly Ser Arg Ile Val Met Ile Val Gly Gly Cys Leu Ser 
                 85                  90                  95
Gly Cys Gly Leu Ile Ala Ala Ser Phe Cys Asn Thr Val Gln Gln Leu 
             100                105                110
Tyr Val Cys Ile Gly Val Ile Gly Gly Leu Gly Leu Ala Phe Asn Leu 
         115                120                125
Asn Pro Ala Leu Thr Met Ile Gly Lys Tyr Phe Tyr Lys Arg Arg Pro 
     130                135                140
Leu Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Cys Thr 
 145                150                155                160
Leu Ala Pro Leu Asn Gln Val Phe Phe Gly Ile Phe Gly Trp Arg Gly 
                 165                170                175
Ser Phe Leu Ile Leu Gly Gly Leu Leu Leu Asn Cys Cys Val Ala Gly 
             180                185                190
Ala Leu Met Arg Pro Ile Gly Pro Lys Pro Thr Lys Ala Gly Lys Asp 
         195                200                205
Lys Ser Lys Ala Ser Leu Glu Lys Ala Gly Lys Ser Gly Val Lys Lys 
     210                215                220
Asp Leu His Asp Ala Asn Thr Asp Leu Ile Gly Arg His Pro Lys Gln 
 225                230                235                240
Glu Lys Arg Ser Val Phe Gln Thr Ile Asn Gln Phe Leu Asp Leu Thr 
                 245                250                255
Leu Phe Thr His Arg Gly Phe Leu Leu Tyr Leu Ser Gly Asn Val Ile 
             260                265                270
Met Phe Phe Gly Leu Phe Ala Pro Leu Val Phe Leu Ser Ser Tyr Gly 
         275                280                285
Lys Ser Gln His Tyr Ser Ser Glu Lys Ser Ala Phe Leu Leu Ser Ile 
     290                295                300
Leu Ala Phe Val Asp Met Val Ala Arg Pro Ser Met Gly Leu Val Ala 
 305                310                315                320
Asn Thr Lys Pro Ile Arg Pro Arg Ile Gln Tyr Phe Phe Ala Ala Ser 
                 325                330                335
Val Val Ala Asn Gly Val Cys His Met Leu Ala Pro Leu Ser Thr Thr 
             340                345                350
Tyr Val Gly Phe Cys Val Tyr Ala Gly Phe Phe Gly Phe Ala Phe Gly 
         355                360                365
Trp Leu Ser Ser Val Leu Phe Glu Thr Leu Met Asp Leu Val Gly Pro 
     370                375                380
Gln Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile Val Glu Cys Cys 
 385                390                395                400
Pro Val Leu Leu Gly Pro Pro Leu Leu Gly Arg Leu Asn Asp Met Tyr 
                 405                410                415
Gly Asp Tyr Lys Tyr Thr Tyr Trp Ala Cys Gly Val Val Leu Ile Ile 
             420                425                430
Ser Gly Ile Tyr Leu Phe Ile Gly Met Gly Ile Asn Tyr Arg Leu Leu 
         435                440                445
Ala Lys Glu Gln Lys Ala Asn Glu Gln Lys Lys Glu Ser Lys Glu Glu 
     450                455                460
Glu Thr Ser Ile Asp Val Ala Gly Lys Pro Asn Glu Val Thr Lys Ala 
 465                470                475                480
Ala Glu Ser Pro Asp Gln Lys Asp Thr Glu Gly Gly Pro Lys Glu Glu 
                 485                490                495
Glu Ser Pro Val 
             500



<210> 2135
<211> 3519
<212> DNA
<213> Rattus norvegicus
<308> D63886
<400> 2135

ctggagggg  gcagagagg  gggaaggag  agcggaggc  gtgagctgg  agcggctga  60
gcccttccc  cagaaactg  gggcaccgg  ggcgtagga  gtggagaag  cggaggacg  120
acgggctgg  ggcggcggc  gcgactcgg  ggcgctggg  atcggaacc  cgggtgaac  180
tgggcgcca  gttccgggc  acggccggg  gaggatggt  aacacttgc  gccgctgac  240
ctgcctttc  tctgtttcc  cgcgggttg  cgagcctgg  gcccatccc  acccctgga  300
gggtgggtg  acctgcaag  ttctaccca  cccaggact  ttttttctt  taaaaggaa  360
cagggagtg  gcattcgga  agagggaga  aacgcaggg  agctcgtcc  tccgttgag  420
cagagttca  tatgatctt  ctcgcattc  gctctggaa  aaggttgga  ttcgtgcat  480
gttcggggg  gtttttctt  caaaccttg  tttggattt  atgtgctac  gtctgcgga  540
cggagcagt  tttcaatgt  gaggtttgg  tacagaaat  cggctacct  ccaccgact  600
accccagaa  gtctgtgct  cgctctgca  agaccatgc  gtcagcctt  gctgccatg  660
agcagttct  tggcattaa  atgacagga  aagtggaca  aaacacaat  gactggatg  720
agaagcctc  atgtggtgt  ccagaccaa  caagaggca  ctctaaatt  aacatccga  780
gaaagcgct  tgcattaac  gggcagaag  ggcaacaca  gcatatcac  tacagtata  840
agaacgtaa  tcccaaggt  ggagatcct  agacccgga  agcaattcg  cgtgccttt  900
atgtgtggc  gaatgtaac  cctctaacg  ttgaagaag  tccctacag  gaactagaa  960
atggcaaac  tgatgtgga  ataaccatc  tttttgctt  tggtttcca  ggagacaga  1020
ccccctttg  tggggaggg  ggatttttg  cccatgctt  tttccctgg  ccaggaatt  1080
gaggcgata  tcattttga  tctgatgag  catggacac  gggaaatcc  aatcatgat  1140
gaaatgatt  atttcttgt  gcagtccat  agctgggac  tgctctagg  ctggagcat  1200
ccaacgacc  aacagctat  atggcacca  tttaccagt  catggaaac  gacaacttc  1260
agcttccta  tgatgattt  caaggcatc  agaagatat  tggtccacc  gacaagatc  1320
ctccaccta  aagacctct  ccgacagtg  cccctcacc  atctgtccc  ccggccgac  1380
caaggaaaa  tgacaggcc  aaacctcct  gacctccca  tggcagacc  tcctatcca  1440
gagccaaac  caacatctg  gatgggaac  tcaacactc  agctattct  cgaagggag  1500
tgtttgttt  caaggacca  tggttttgg  gagtgagaa  caacagggt  atggatgga  1560
accccatgc  aattactta  ttctggcgg  gccttcctc  cagtattga  gcagtttat  1620
aaaacagtg  tggaaattt  gtcttcttt  aaggtaaca  atactgggt  ttcaaagac  1680
caactcttc  acctggata  cctcatgac  tgattaccc  tggaaatgg  atcccccct  1740
atggtattg  ttctgccat  tggtgggaa  atgttggca  aacctattt  ttcaaaggc  1800
accggtatt  gagatatag  gaagaaatg  aaaccatgg  ccctggcta  cccaagccc  1860
tcaccatct  gaaaggaat  cctgaatca  ctcagggag  tttcgtcca  aaggaaaat  1920
gctttacct  tttctacaa  ggaaaggag  attggaaat  caacaacca  atactcaaa  1980
tagaacctg  gtatccaag  tccatcctc  aggacttta  gggctgtga  ggaccaaca  2040
accgagata  agaaggtct  agcccacca  catgatgta  acattgtca  caaactgga  2100
aacacagcc  gcactgtga  agccatagc  attgtcatt  cctgcatct  ggccttatg  2160
cctccttgt  ttggtttac  ctgtgttcc  gttcaagcg  aaaggaaca  cccgccaca  2220
actgtactg  aaacgctct  tgcaagagt  ggtgtgatg  agggatttc  tttttcttt  2280
ttttccgga  tttgtggta  cttgagatt  aagacaaga  ctgttatgc  gtttcctag  2340
taggagcag  cttgtggca  ctgatcgag  ctgaccttc  aaacctaga  ggttgctgg  2400
cctgcacat  agtggaaat  tattcatgg  gaaacttcc  tgatgcaca  tatctgccg  2460
tcttcagtc  tctgtcttt  tttgtcatt  agttctagg  tttcctctg  acgctcaat  2520
cccagtaaa  tttcaggat  aactgaaga  gaggaaata  agaagaaaa  tttcttctt  2580
ttttttttt  aaatacttt  ccttctgaa  tctgagccc  tttctggga  agagaaaga  2640
agagagaga  agagagaga  agagagaga  agagagaga  agagagaga  aaagcaaat  2700
agaaaaccc  taggttttt  ctttaaagc  aaagagagt  taaaaacaa  aaaatccac  2760
actgaactt  cagaaaagt  tgaagatcc  aaacagctt  gtctccaaa  aagatagct  2820
tgtgaccac  atggatagt  tcctgcgca  tgtcttgtc  ggtgggaga  ctggaacat  2880
catgcagga  gctagactg  tgggacaga  attttccaa  aaacaaggg  ccaaaatat  2940
tgcaatata  taacagcct  aataataca  gcattttca  tttctacag  tgttctcaa  3000
tatgtccac  atgtatcat  acctccata  tcatagctg  attcaaaca  gaccttttg  3060
ttgttttga  atgtttctg  accccctct  gcctcctga  acagcatca  tgtgacatt  3120
ttcccagtt  tgttaggcc  ttgtcccag  ccgtccatt  gtctgtcag  aatactcag  3180
gcaaagcag  gcgagaagc  ttgtgtctc  gaagtaaag  aagtgatgg  catattata  3240
agatatgtt  ctctttaat  catcggtgt  accctttga  aactatcag  ccagcttac  3300
gagtcagga  gatcagtct  gcaatctgg  catttgtag  agtggccaa  agggaaagc  3360
atcacatgt  cgagaagtt  agacttgta  agcatacct  acaatccca  gtaattctt  3420
aatgactga  agtactgca  aaatgcttt  ataacaaac  acagtggtg  gacttgcca  3480
aacttttct  gcaaataaa  aagatattt  gttaacaat  3519



<210> 2136
<211> 607
<212> PRT
<213> Rattus norvegicus
<308> BAA22223
<400> 2136

Met Ile Leu Leu Ala Phe Ser Ser Gly Arg Arg Leu Asp Phe Val His 
  1               5                  10                  15
Arg Ser Gly Val Phe Phe Phe Gln Thr Leu Leu Trp Ile Leu Cys Ala 
             20                  25                  30
Thr Val Cys Gly Thr Glu Gln Tyr Phe Asn Val Glu Val Trp Leu Gln 
         35                  40                  45
Lys Tyr Gly Tyr Leu Pro Pro Thr Asp Pro Arg Met Ser Val Leu Arg 
     50                  55                  60
Ser Ala Glu Thr Met Gln Ser Ala Leu Ala Ala Met Gln Gln Phe Tyr 
 65                  70                  75                  80
Gly Ile Asn Met Thr Gly Lys Val Asp Arg Asn Thr Ile Asp Trp Met 
                 85                  90                  95
Lys Lys Pro Arg Cys Gly Val Pro Asp Gln Thr Arg Gly Ser Ser Lys 
             100                105                110
Phe Asn Ile Arg Arg Lys Arg Tyr Ala Leu Thr Gly Gln Lys Trp Gln 
         115                120                125
His Lys His Ile Thr Tyr Ser Ile Lys Asn Val Thr Pro Lys Val Gly 
     130                135                140
Asp Pro Glu Thr Arg Arg Ala Ile Arg Arg Ala Phe Asp Val Trp Gln 
 145                150                155                160
Asn Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr Ser Glu Leu Glu 
                 165                170                175
Asn Gly Lys Arg Asp Val Asp Ile Thr Ile Ile Phe Ala Ser Gly Phe 
             180                185                190
His Gly Asp Arg Ser Pro Phe Asp Gly Glu Gly Gly Phe Leu Ala His 
         195                200                205
Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr His Phe Asp Ser 
     210                215                220
Asp Glu Pro Trp Thr Leu Gly Asn Pro Asn His Asp Gly Asn Asp Leu 
 225                230                235                240
Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His 
                 245                250                255
Ser Asn Asp Pro Thr Ala Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu 
             260                265                270
Thr Asp Asn Phe Lys Leu Pro Asn Asp Asp Leu Gln Gly Ile Gln Lys 
         275                280                285
Ile Tyr Gly Pro Pro Asp Lys Ile Pro Pro Pro Thr Arg Pro Leu Pro 
     290                295                300
Thr Val Pro Pro His Arg Ser Val Pro Pro Ala Asp Pro Arg Lys Asn 
 305                310                315                320
Asp Arg Pro Lys Pro Pro Arg Pro Pro Thr Gly Arg Pro Ser Tyr Pro 
                 325                330                335
Gly Ala Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn Thr Leu Ala Ile 
             340                345                350
Leu Arg Arg Glu Met Phe Val Phe Lys Asp Gln Trp Phe Trp Arg Val 
         355                360                365
Arg Asn Asn Arg Val Met Asp Gly Tyr Pro Met Gln Ile Thr Tyr Phe 
     370                375                380
Trp Arg Gly Leu Pro Pro Ser Ile Asp Ala Val Tyr Glu Asn Ser Asp 
 385                390                395                400
Gly Asn Phe Val Phe Phe Lys Gly Asn Lys Tyr Trp Val Phe Lys Asp 
                 405                410                415
Thr Thr Leu Gln Pro Gly Tyr Pro His Asp Leu Ile Thr Leu Gly Asn 
             420                425                430
Gly Ile Pro Pro His Gly Ile Asp Ser Ala Ile Trp Trp Glu Asp Val 
         435                440                445
Gly Lys Thr Tyr Phe Phe Lys Gly Asp Arg Tyr Trp Arg Tyr Ser Glu 
     450                455                460
Glu Met Lys Thr Met Asp Pro Gly Tyr Pro Lys Pro Ile Thr Ile Trp 
 465                470                475                480
Lys Gly Ile Pro Glu Ser Pro Gln Gly Ala Phe Val His Lys Glu Asn 
                 485                490                495
Gly Phe Thr Tyr Phe Tyr Lys Gly Lys Glu Tyr Trp Lys Phe Asn Asn 
             500                505                510
Gln Ile Leu Lys Val Glu Pro Gly Tyr Pro Arg Ser Ile Leu Lys Asp 
         515                520                525
Phe Met Gly Cys Asp Gly Pro Thr Asp Arg Asp Lys Glu Gly Leu Ser 
     530                535                540
Pro Pro Asp Asp Val Asp Ile Val Ile Lys Leu Asp Asn Thr Ala Ser 
 545                550                555                560
Thr Val Lys Ala Ile Ala Ile Val Ile Pro Cys Ile Leu Ala Leu Cys 
                 565                570                575
Leu Leu Val Leu Val Tyr Thr Val Phe Gln Phe Lys Arg Lys Gly Thr 
             580                585                590
Pro Arg His Ile Leu Tyr Cys Lys Arg Ser Met Gln Glu Trp Val 
         595                600                605



<210> 2137
<211> 2589
<212> DNA
<213> Homo sapiens
<308> NM_005941
<400> 2137

ggctcctta  ccacccgga  acttttttt  gaaaggaaa  tagggaggg  gggagaggg  60
gagagggag  aaacgaagg  gagctcgtc  atccattga  gcacagttc  ctatgatct  120
actcacatt  agcactgga  gacggttgg  tttcgtgca  cattcgggg  tgtttttct  180
gcaaacctt  ctttggatt  tatgtgcta  agtctgcgg  acggagcag  atttcaatg  240
ggaggtttg  ttacaaaag  acggctacc  tccaccgac  gaccccaga  tgtcagtgc  300
gcgctctgc  gagaccatg  agtctgccc  agctgccat  cagcagttc  atggcatta  360
catgacagg  aaagtggac  gaaacacaa  tgactggat  aagaagccc  gatgcggtg  420
acctgacca  acaagaggt  gctccaaat  tcatattcg  cgaaagcga  atgcattga  480
aggacagaa  tggcagcac  agcacatca  ttacagtat  aagaacgta  ctccaaaag  540
aggagaccc  gagactcgt  aagctattc  ccgtgcctt  gatgtgtgg  agaatgtaa  600
tcctctgac  tttgaagaa  ttccctaca  tgaattaga  aatggcaaa  gtgatgtgg  660
tataaccat  atttttgca  ctggtttcc  tggggacag  tctcccttt  atggagagg  720
aggattttt  gcacatgcc  acttccctg  accaggaat  ggaggagat  cccattttg  780
ctcagatga  ccatggaca  taggaaatc  taatcatga  ggaaatgac  tatttcttg  840
agcagtcca  gaactggga  atgctctgg  attggagca  tccaatgac  ccactgcca  900
catggctcc  ttttaccag  acatggaaa  agacaactt  aaactacct  atgatgatt  960
acagggcat  cagaagata  atggtccac  tgacaagat  cctccacct  caagacctc  1020
accgacagt  cccccacac  gctctattc  tccggctga  ccaaggaaa  atgacaggc  1080
aaaacctcc  cggcctcca  ccggcagac  ctcctatcc  ggagccaaa  ccaacatct  1140
tgatgggaa  tttaacact  tagctattc  tcgtcgtga  atgtttgtt  tcaaggacc  1200
gtggttttg  cgagtgaga  acaacaggg  gatggatgg  tacccaatg  aaattactt  1260
cttctggcg  ggcttgcct  ctagtatcg  tgcagttta  gaaaatagc  acgggaatt  1320
tgtgttctt  aaaggtaac  aatattggg  gttcaagga  acaactctt  aacctggtt  1380
ccctcatga  ttgataacc  ttggaagtg  aattccccc  catggtatt  attcagcca  1440
ttggtggga  gacgtcggg  aaacctatt  cttcaaggg  gacagatat  ggagatata  1500
tgaagaaat  aaaacaatg  accctggct  tcccaagcc  atcacagtc  ggaaaggga  1560
ccctgaatc  cctcaggga  catttgtac  caaagaaaa  ggctttacg  atttctaca  1620
aggaaagga  tattggaaa  tcaacaacc  gatactcaa  gtagaacct  gatatccaa  1680
atccatcct  aaggatttt  tgggctgtg  tggaccaac  gacagagtt  aagaaggac  1740
cagcccacc  gatgatgta  acattgtca  caaactgga  aacacagcc  gcactgtga  1800
agccatagc  attgtcatt  cctgcatct  ggccttatg  ctccttgta  tggtttaca  1860
tgtgttcca  ttcaagagg  aaggaacac  ccgccacat  ctgtactgt  aacgctcta  1920
gcaagagtg  gtgtgatgt  gggtttttt  ttctttctt  cttttgcag  agtttgtgg  1980
aacttgaga  tcaagacaa  agctgttat  ctgtttcct  gctaggagc  ggcttgtgg  2040
agcctgatt  ggggctgac  tttcaaacc  gagggttgc  ggtcctgca  atgagtgga  2100
atacactca  ggggaagct  ccatgatgc  cagtatctg  tgttcttca  tcctttgtc  2160
ttctttgtc  ttcagttct  ggcctttcc  ctgcacgct  aatgcccag  aaaatttca  2220
gattaacta  agaagagga  aaaaagaag  aaagattct  tcttaaaag  ttctaatgt  2280
attttcctt  tgaagtctg  gcccatttc  ggggggaga  aaaaaaagc  aatcagaaa  2340
cccacggtt  ttctttttt  ctttttttc  ttttttctt  tttggcttt  aaacaaagg  2400
aaaaaagag  ttaaacaaa  aacccacaa  tgaacttcc  ggaaagtgt  aagacccaa  2460
acagctttg  ctccaaaga  gatagctct  tgactgctt  ggatagtct  ctacgcacc  2520
ttttgtcag  tgggagatt  ggaatacac  tgcaggacg  tagactgtt  ggacagcca  2580
tttccaaca  2589



<210> 2138
<211> 607
<212> PRT
<213> Homo sapiens
<308> P51512
<400> 2138

Met Ile Leu Leu Thr Phe Ser Thr Gly Arg Arg Leu Asp Phe Val His 
  1               5                  10                  15
His Ser Gly Val Phe Phe Leu Gln Thr Leu Leu Trp Ile Leu Cys Ala 
             20                  25                  30
Thr Val Cys Gly Thr Glu Gln Tyr Phe Asn Val Glu Val Trp Leu Gln 
         35                  40                  45
Lys Tyr Gly Tyr Leu Pro Pro Thr Asp Pro Arg Met Ser Val Leu Arg 
     50                  55                  60
Ser Ala Glu Thr Met Gln Ser Ala Leu Ala Ala Met Gln Gln Phe Tyr 
 65                  70                  75                  80
Gly Ile Asn Met Thr Gly Lys Val Asp Arg Asn Thr Ile Asp Trp Met 
                 85                  90                  95
Lys Lys Pro Arg Cys Gly Val Pro Asp Gln Thr Arg Gly Ser Ser Lys 
             100                105                110
Phe His Ile Arg Arg Lys Arg Tyr Ala Leu Thr Gly Gln Lys Trp Gln 
         115                120                125
His Lys His Ile Thr Tyr Ser Ile Lys Asn Val Thr Pro Lys Val Gly 
     130                135                140
Asp Pro Glu Thr Arg Lys Ala Ile Arg Arg Ala Phe Asp Val Trp Gln 
 145                150                155                160
Asn Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr Ser Glu Leu Glu 
                 165                170                175
Asn Gly Lys Arg Asp Val Asp Ile Thr Ile Ile Phe Ala Ser Gly Phe 
             180                185                190
His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly Phe Leu Ala His 
         195                200                205
Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr His Phe Asp Ser 
     210                215                220
Asp Glu Pro Trp Thr Leu Gly Asn Pro Asn His Asp Gly Asn Asp Leu 
 225                230                235                240
Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His 
                 245                250                255
Ser Asn Asp Pro Thr Ala Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu 
             260                265                270
Thr Asp Asn Phe Lys Leu Pro Asn Asp Asp Leu Gln Gly Ile Gln Lys 
         275                280                285
Ile Tyr Gly Pro Pro Asp Lys Ile Pro Pro Pro Thr Arg Pro Leu Pro 
     290                295                300
Thr Val Pro Pro His Arg Ser Ile Pro Pro Ala Asp Pro Arg Lys Asn 
 305                310                315                320
Asp Arg Pro Lys Pro Pro Arg Pro Pro Thr Gly Arg Pro Ser Tyr Pro 
                 325                330                335
Gly Ala Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn Thr Leu Ala Ile 
             340                345                350
Leu Arg Arg Glu Met Phe Val Phe Lys Asp Gln Trp Phe Trp Arg Val 
         355                360                365
Arg Asn Asn Arg Val Met Asp Gly Tyr Pro Met Gln Ile Thr Tyr Phe 
     370                375                380
Trp Arg Gly Leu Pro Pro Ser Ile Asp Ala Val Tyr Glu Asn Ser Asp 
 385                390                395                400
Gly Asn Phe Val Phe Phe Lys Gly Asn Lys Tyr Trp Val Phe Lys Asp 
                 405                410                415
Thr Thr Leu Gln Pro Gly Tyr Pro His Asp Leu Ile Thr Leu Gly Ser 
             420                425                430
Gly Ile Pro Pro His Gly Ile Asp Ser Ala Ile Trp Trp Glu Asp Val 
         435                440                445
Gly Lys Thr Tyr Phe Phe Lys Gly Asp Arg Tyr Trp Arg Tyr Ser Glu 
     450                455                460
Glu Met Lys Thr Met Asp Pro Gly Tyr Pro Lys Pro Ile Thr Val Trp 
 465                470                475                480
Lys Gly Ile Pro Glu Ser Pro Gln Gly Ala Phe Val His Lys Glu Asn 
                 485                490                495
Gly Phe Thr Tyr Phe Tyr Lys Gly Lys Glu Tyr Trp Lys Phe Asn Asn 
             500                505                510
Gln Ile Leu Lys Val Glu Pro Gly Tyr Pro Arg Ser Ile Leu Lys Asp 
         515                520                525
Phe Met Gly Cys Asp Gly Pro Thr Asp Arg Val Lys Glu Gly His Ser 
     530                535                540
Pro Pro Asp Asp Val Asp Ile Val Ile Lys Leu Asp Asn Thr Ala Ser 
 545                550                555                560
Thr Val Lys Ala Ile Ala Ile Val Ile Pro Cys Ile Leu Ala Leu Cys 
                 565                570                575
Leu Leu Val Leu Val Tyr Thr Val Phe Gln Phe Lys Arg Lys Gly Thr 
             580                585                590
Pro Arg His Ile Leu Tyr Cys Lys Arg Ser Met Gln Glu Trp Val 
         595                600                605



<210> 2139
<211> 2175
<212> DNA
<213> Rattus norvegicus
<308> D64045
<400> 2139

atgagcgca  aggggtacc  gtacagagc  ctgtatgac  acaaaaagg  acgagagga  60
gacatcgac  tacacttgg  ggacatcct  actgtgaat  aaggctcct  agtggcact  120
ggattcagt  atggccagg  agcccggcc  gaagatatt  gctggttaa  tggttacaa  180
gaaactact  gggagaggg  agactttcc  ggaacttat  ttgagtaca  tggaaggaa  240
agaatttca  cccccactc  taagccacg  ccccctcga  ctcttcctg  agcacccgg  300
tcttcaaaa  ctgaagcag  cactgagca  ccagtgttg  cccttcctg  tctggccga  360
cagtttgcc  ctcctgatg  tgccccgcc  ctccttata  agctcctgg  agccattga  420
aagaaagga  tggaatgtt  aactctata  agaacacag  gctccagca  ccctgcaga  480
ttacgacag  ttcttgatt  tgatccccc  tcagtggac  tggatgtgt  cgatgaaca  540
gttttagca  atgctttca  acgctatct  gccgactta  caaatcctg  cattccagt  600
gctgtttac  atgagatga  gtctttagc  caagaagta  caagctccg  agactacat  660
cagctgttg  agaagctca  taggtcgcc  aatatacct  atcagtatt  gcttacgct  720
cagtatttg  tcaagcact  cttcaagct  tctcaagcc  ccagcaaga  ccttctgaa  780
gcaagagcc  tctctgaaa  tttcagcca  gtgcttttc  gattcccag  agccagctc  840
gataatact  aacacctca  aaaagcggt  gagctttta  tctcagcgg  gtggagtga  900
cgacagcca  caccagcac  gccccctaa  ccacccaag  ccacttcta  agccaacaa  960
agcatgaac  acaatatgt  cttacagga  gctgaatgg  actggggag  tatctcaag  1020
gaagaagta  atgaaaaac  ccgagacac  gctgatggg  cctttctgg  acgagatgc  1080
tccactaaa  tgcacggng  ctacactct  acactaagg  aaggaggaa  taacaaatt  1140
atcaaaatc  ttcaccgag  tgggaaata  ggtttctct  atccattaa  cttcaactc  1200
gtggttgaa  taataaacc  ctaccggaa  gagtcctta  ctcagtaca  tcccaagct  1260
gatgtgaag  tactctacc  agtgtctaa  taccagcag  atcaagttg  caaagaaga  1320
aatattgaa  ctgtgggga  aaaattaca  gaatataat  ctcaatttc  agaaaaaag  1380
cgggaatat  atagattat  tgaggaata  actcgtact  cccaggaaa  acagatgaa  1440
agaacagct  tcgaagcat  taatgacac  ataaaaata  tcgaagagc  gtgccaccc  1500
caggagcgg  acagcaaag  ctacataga  aagtttaaa  gcgaaggca  cgagaagga  1560
attcaaagg  taatgcata  tcacgataa  ctgaagtct  ggatcagcg  gatcatcga  1620
agcaggagg  gactggagg  agacttgaa  aagcaggca  ccgagtatc  cgagatcga  1680
aagcgcatg  atagcatta  gccggacct  attcagctg  gaaagacaa  agatcaata  1740
ttgatgtgg  tgacgcaga  aggggtccg  cagaagaag  tgaacgaat  gttgggaaa  1800
gaaaacaca  aagaccaat  ctcactggt  gacgatgac  aggatttgc  ccaccatga  1860
gagaagacg  ggaatgtgg  gagcagcaa  cgaaacaaa  ccgagaacc  attgcgagg  1920
aaacgagat  gcactttcc  ggtccggga  agcagtaag  agggctgct  tgcctgctc  1980
gtagtggta  atggcgaag  caaacattg  gtcatcaac  agactgcca  cggctatgg  2040
ttcgccgag  cctacaacc  gtacagctc  ctgaaagag  tggtgctac  ttaccaaca  2100
acctccctg  tgcagcaca  tgactccct  aatgtcaca  tagcatacc  agtatatgc  2160
caacagagg  gatga  2175



<210> 2140
<211> 724
<212> PRT
<213> Rattus norvegicus
<308> Q63787
<400> 2140

Met Ser Ala Glu Gly Tyr Gln Tyr Arg Ala Leu Tyr Asp Tyr Lys Lys 
  1               5                  10                  15
Glu Arg Glu Glu Asp Ile Asp Leu His Leu Gly Asp Ile Leu Thr Val 
             20                  25                  30
Asn Lys Gly Ser Leu Val Ala Leu Gly Phe Ser Asp Gly Gln Glu Ala 
         35                  40                  45
Arg Pro Glu Asp Ile Gly Trp Leu Asn Gly Tyr Asn Glu Thr Thr Gly 
     50                  55                  60
Glu Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Tyr Ile Gly Arg Lys 
 65                  70                  75                  80
Arg Ile Ser Pro Pro Thr Pro Lys Pro Arg Pro Pro Arg Pro Leu Pro 
                 85                  90                  95
Val Ala Pro Gly Ser Ser Lys Thr Glu Ala Asp Thr Glu Gln Pro Val 
             100                105                110
Leu Thr Leu Pro Asp Leu Ala Glu Gln Phe Ala Pro Pro Asp Val Ala 
         115                120                125
Pro Pro Leu Leu Ile Lys Leu Leu Glu Ala Ile Glu Lys Lys Gly Leu 
     130                135                140
Glu Cys Ser Thr Leu Tyr Arg Thr Gln Ser Ser Ser Asn Pro Ala Glu 
 145                150                155                160
Leu Arg Gln Leu Leu Asp Cys Asp Pro Pro Ser Val Asp Leu Asp Val 
                 165                170                175
Phe Asp Glu His Val Leu Ala Asp Ala Phe Lys Arg Tyr Leu Ala Asp 
             180                185                190
Leu Pro Asn Pro Val Ile Pro Val Ala Val Tyr Asn Glu Met Met Ser 
         195                200                205
Leu Ala Gln Glu Val Pro Ser Ser Glu Asp Tyr Ile Gln Leu Leu Lys 
     210                215                220
Lys Leu Ile Arg Ser Pro Asn Ile Pro His Gln Tyr Trp Leu Thr Leu 
 225                230                235                240
Gln Tyr Leu Leu Lys His Phe Phe Lys Leu Ser Gln Ala Ser Ser Lys 
                 245                250                255
Asn Leu Leu Asn Ala Arg Ala Leu Ser Glu Ile Phe Ser His Val Leu 
             260                265                270
Phe Arg Phe Pro Ala Ala Ser Ser Asp Asn Thr Glu His Leu Ile Lys 
         275                280                285
Ala Val Glu Leu Leu Ile Ser Ala Glu Trp Ser Glu Arg Gln Pro Ala 
     290                295                300
Pro Ala Leu Pro Pro Lys Pro Pro Lys Pro Thr Ser Ile Ala Asn Asn 
 305                310                315                320
Ser Met Asn Asn Asn Met Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly 
                 325                330                335
Asp Ile Ser Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Ala Asp 
             340                345                350
Gly Thr Phe Leu Val Arg Asp Ala Ser Thr Lys Met His Gly Asp Tyr 
         355                360                365
Thr Leu Thr Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Ile Phe 
     370                375                380
His Arg Asp Gly Lys Tyr Gly Phe Ser Asp Pro Leu Thr Phe Asn Ser 
 385                390                395                400
Val Val Glu Leu Ile Asn His Tyr Arg Asn Glu Ser Leu Ala Gln Tyr 
                 405                410                415
Asn Pro Lys Leu Asp Val Lys Leu Leu Tyr Pro Val Ser Lys Tyr Gln 
             420                425                430
Gln Asp Gln Val Val Lys Glu Asp Asn Ile Glu Ala Val Gly Lys Lys 
         435                440                445
Leu His Glu Tyr Asn Thr Gln Phe Gln Glu Lys Ser Arg Glu Tyr Asp 
     450                455                460
Arg Leu Tyr Glu Glu Tyr Thr Arg Thr Ser Gln Glu Ile Gln Met Lys 
 465                470                475                480
Arg Thr Ala Ile Glu Ala Phe Asn Asp Thr Ile Lys Ile Phe Glu Glu 
                 485                490                495
Gln Cys His Pro Gln Glu Arg Tyr Ser Lys Asp Tyr Ile Glu Lys Phe 
             500                505                510
Lys Arg Glu Gly Asn Glu Lys Glu Ile Gln Arg Ile Met His Asn His 
         515                520                525
Asp Lys Leu Lys Ser Arg Ile Ser Glu Ile Ile Asp Ser Arg Arg Arg 
     530                535                540
Leu Glu Glu Asp Leu Lys Lys Gln Ala Ala Glu Tyr Arg Glu Ile Asp 
 545                550                555                560
Lys Arg Met Asn Ser Ile Lys Pro Asp Leu Ile Gln Leu Arg Lys Thr 
                 565                570                575
Arg Asp Gln Tyr Leu Met Trp Leu Thr Gln Lys Gly Val Arg Gln Lys 
             580                585                590
Lys Leu Asn Glu Trp Leu Gly Asn Glu Asn Thr Glu Asp Gln Tyr Ser 
         595                600                605
Leu Val Asp Asp Asp Glu Asp Leu Pro His His Asp Glu Lys Thr Trp 
     610                615                620
Asn Val Gly Ser Ser Asn Arg Asn Lys Ala Glu Asn Leu Leu Arg Gly 
 625                630                635                640
Lys Arg Asp Gly Thr Phe Leu Val Arg Glu Ser Ser Lys Gln Gly Cys 
                 645                650                655
Tyr Ala Cys Ser Val Val Val Asp Gly Glu Val Lys His Cys Val Ile 
             660                665                670
Asn Lys Thr Ala Thr Gly Tyr Gly Phe Ala Glu Pro Tyr Asn Leu Tyr 
         675                680                685
Ser Ser Leu Lys Glu Leu Val Leu His Tyr Gln His Thr Ser Leu Val 
     690                695                700
Gln His Asn Asp Ser Leu Asn Val Thr Leu Ala Tyr Pro Val Tyr Ala 
 705                710                715                720
Gln Gln Arg Arg 
                 725



<210> 2141
<211> 3362
<212> DNA
<213> Homo sapiens
<308> XM_043865
<400> 2141

tacaaccag  ctcaactgt  gcatggtag  agatttgca  acatgagtg  tgaggggta  60
cagtacaga  cgctgtatg  ttataaaaa  gaaagagaa  aagatattg  cttgcactt  120
ggtgacata  tgactgtga  taaagggtc  ttagtagct  ttggattca  tgatggaca  180
gaagccagg  ctgaagaaa  tggctggtt  aatggctat  atgaaacca  aggggaaag  240
ggggacttt  cgggaactt  cgtagaata  attggaagg  aaaaaatct  gcctcccac  300
ccaaagccc  ggccacctc  gcctcttcc  gttgcacca  gttcttcga  aactgaagc  360
gatgttgaa  aacaagctt  gactctccc  gatcttgca  agcagtttg  ccctcctga  420
attgccccg  ctcttctta  caagctcgt  gaagccatt  aaaagaaag  tctggaatg  480
tcaactcta  acagaacac  gagctccag  aacctggca  aattacgac  gcttcttga  540
tgtgataca  cctccgtgg  cttggaaat  atcgatgtg  acgttttgg  tgacgcttt  600
aaacgctat  tcctggact  accaaatcc  gtcattcca  cagccgttt  cagtgaaat  660
atttcttta  ctccagaag  acaaagctc  gaagaatat  ttcagctat  gaagaagct  720
attaggtcg  ctagcatac  tcatcagta  tggcttacg  ttcagtatt  gttaaaaca  780
ttcttcaag  tctctcaaa  ctccagcaa  aatctgttg  atgcaagag  actctctga  840
attttcagc  ctatgcttt  cagattctc  gcagccagc  ctgataata  tgaaaacct  900
ataaaagtt  tagaaattt  aatctcaac  gaatggaat  aacgacagc  tgcaccagc  960
ctgcctcct  aaccaccaa  acctactac  gtagccaac  acggtatga  taacaatat  1020
tccttacaa  atgctgaat  gtactgggg  gatatctcg  gggaagaag  gaatgaaaa  1080
cttcgagat  cagcagacg  gaccttttt  gtacgagat  cgtctacta  aatgcatgg  1140
gattatact  ttacactaa  gaaaggggg  aataacaaa  taatcaaaa  atttcatcg  1200
gatgggaaa  atggcttct  tgacccatt  accttcagt  ctgtggttg  attaataaa  1260
cactaccgg  atgaatctc  agctcagta  aatcccaaa  tggatgtga  attacttta  1320
ccagtatcc  aataccaac  ggatcaagt  gtcaaagaa  ataatattg  agctgtagg  1380
aaaaaatta  atgaatata  cactcagtt  caagaaaaa  gtcgagaat  tgatagatt  1440
tatgaagaa  atacccgca  atcccagga  atccaaatg  aaaggacag  tattgaagc  1500
tttaatgaa  ccataaaaa  atttgaaga  cagtgccag  cccaagagc  gtacagcaa  1560
gaatacata  aaaagttta  acgtgaagg  aatgagaaa  aaatacaaa  gattatgca  1620
aattatgat  agttgaagt  tcgaatcag  gaaattatt  acagtagaa  aagattgga  1680
gaagacttg  agaagcagg  agctgagta  cgagaaatt  acaaacgta  gaacagcat  1740
aaaccagac  ttatccagc  gagaaagac  agagaccaa  acttgatgt  gttgactca  1800
aaaggtgtt  ggcaaaaga  gttgaacga  tggttgggc  atgaaaaca  tgaagacca  1860
tattcactg  tggaagatg  tgaagattt  ccccatcat  atgagaaga  atggaatgt  1920
ggaagcagc  accgaaaca  agctgaaaa  ctgttgcga  ggaagcgag  tggcacttt  1980
cttgtccgg  agagcagta  acagggctg  tatgcctgc  ctgtagtgg  ggacggcga  2040
gtaaagcat  gtgtcataa  caaaacagc  actggctat  gctttgccg  gccctataa  2100
ttgtacagc  ctctgaaag  actggtgct  cattaccaa  acacctccc  tgtgcagca  2160
aacgactcc  tcaatgtca  actagccta  ccagtatat  cacagcaga  gcgatgaag  2220
gcttactct  tgatccttc  cctgaagtt  agccaccct  aggcctctg  aaagcaaag  2280
gctcctctc  agtctgatc  gtgaattga  ctgcagaaa  gaagccatc  ttctttgga  2340
gggactaga  ctttctttc  caaaaaaga  gtaggggaa  acatgcagc  taaggctgt  2400
tgatgacca  acgttccta  gctggagtg  ttatccctt  tttttcttt  tttctttgg  2460
ttaatttaa  gccacaacc  catacaaca  aaagagaaa  agaaatgca  aaatctctg  2520
gtgcaggga  aaagaggcc  ttaaccatg  tgcttgtta  tgctttctg  agctttacc  2580
gctgaaagt  gggactctg  agagcggag  agagagagg  agaagaacc  tggcctgag  2640
aggtttggt  cagcctggt  tagcctgga  gttgctgtg  acggtggac  cagacacat  2700
gcactgtgg  ttatttcat  ttgtaacaa  tgaacgata  gtagcagaa  ggcacgtcc  2760
ctcacaagg  acgctttgg  agaatgtca  ttcatgtat  ttcagaaga  attctgtca  2820
agaaagtgc  agaaagtgt  taacttgtc  aaaaacaaa  acccagcaa  agaaaaatg  2880
agtttggaa  acaggactt  aaatgacat  cagtatata  aatatgtac  taatattgg  2940
tgactaact  tcaaataga  ggatttgta  caataccaa  tagcttctg  tttgttttg  3000
tgaaggcta  attcacagc  ctatgcaat  cttaatttt  attaagttg  tatttcagt  3060
ttaaatgta  cttcagaat  agcttcccc  ccccagttt  tgttgcttg  aaatattgt  3120
gtcccggat  tttgttaat  ttcattttt  ttatccttt  ttaaaagta  atgtacagg  3180
tgccagtaa  aaaaaaaaa  ggcttcaga  ttaaaacta  gaaatattt  acagttttt  3240
ttgtacaga  tacttggct  ttagcccaa  gttaaaaag  tcataacag  ttttttttg  3300
actgttttg  tgggcagtg  ctgataagc  tcaaagctg  tttattcaa  aaaaaaaag  3360
aa  3362



<210> 2142
<211> 724
<212> PRT
<213> Homo sapiens
<308> XP_043865
<400> 2142

Met Ser Ala Glu Gly Tyr Gln Tyr Arg Ala Leu Tyr Asp Tyr Lys Lys 
  1               5                  10                  15
Glu Arg Glu Glu Asp Ile Asp Leu His Leu Gly Asp Ile Leu Thr Val 
             20                  25                  30
Asn Lys Gly Ser Leu Val Ala Leu Gly Phe Ser Asp Gly Gln Glu Ala 
         35                  40                  45
Arg Pro Glu Glu Ile Gly Trp Leu Asn Gly Tyr Asn Glu Thr Thr Gly 
     50                  55                  60
Glu Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Tyr Ile Gly Arg Lys 
 65                  70                  75                  80
Lys Ile Ser Pro Pro Thr Pro Lys Pro Arg Pro Pro Arg Pro Leu Pro 
                 85                  90                  95
Val Ala Pro Gly Ser Ser Lys Thr Glu Ala Asp Val Glu Gln Gln Ala 
             100                105                110
Leu Thr Leu Pro Asp Leu Ala Glu Gln Phe Ala Pro Pro Asp Ile Ala 
         115                120                125
Pro Pro Leu Leu Ile Lys Leu Val Glu Ala Ile Glu Lys Lys Gly Leu 
     130                135                140
Glu Cys Ser Thr Leu Tyr Arg Thr Gln Ser Ser Ser Asn Leu Ala Glu 
 145                150                155                160
Leu Arg Gln Leu Leu Asp Cys Asp Thr Pro Ser Val Asp Leu Glu Met 
                 165                170                175
Ile Asp Val His Val Leu Ala Asp Ala Phe Lys Arg Tyr Leu Leu Asp 
             180                185                190
Leu Pro Asn Pro Val Ile Pro Ala Ala Val Tyr Ser Glu Met Ile Ser 
         195                200                205
Leu Ala Pro Glu Val Gln Ser Ser Glu Glu Tyr Ile Gln Leu Leu Lys 
     210                215                220
Lys Leu Ile Arg Ser Pro Ser Ile Pro His Gln Tyr Trp Leu Thr Leu 
 225                230                235                240
Gln Tyr Leu Leu Lys His Phe Phe Lys Leu Ser Gln Thr Ser Ser Lys 
                 245                250                255
Asn Leu Leu Asn Ala Arg Val Leu Ser Glu Ile Phe Ser Pro Met Leu 
             260                265                270
Phe Arg Phe Ser Ala Ala Ser Ser Asp Asn Thr Glu Asn Leu Ile Lys 
         275                280                285
Val Ile Glu Ile Leu Ile Ser Thr Glu Trp Asn Glu Arg Gln Pro Ala 
     290                295                300
Pro Ala Leu Pro Pro Lys Pro Pro Lys Pro Thr Thr Val Ala Asn Asn 
 305                310                315                320
Gly Met Asn Asn Asn Met Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly 
                 325                330                335
Asp Ile Ser Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Ala Asp 
             340                345                350
Gly Thr Phe Leu Val Arg Asp Ala Ser Thr Lys Met His Gly Asp Tyr 
         355                360                365
Thr Leu Thr Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Ile Phe 
     370                375                380
His Arg Asp Gly Lys Tyr Gly Phe Ser Asp Pro Leu Thr Phe Ser Ser 
 385                390                395                400
Val Val Glu Leu Ile Asn His Tyr Arg Asn Glu Ser Leu Ala Gln Tyr 
                 405                410                415
Asn Pro Lys Leu Asp Val Lys Leu Leu Tyr Pro Val Ser Lys Tyr Gln 
             420                425                430
Gln Asp Gln Val Val Lys Glu Asp Asn Ile Glu Ala Val Gly Lys Lys 
         435                440                445
Leu His Glu Tyr Asn Thr Gln Phe Gln Glu Lys Ser Arg Glu Tyr Asp 
     450                455                460
Arg Leu Tyr Glu Glu Tyr Thr Arg Thr Ser Gln Glu Ile Gln Met Lys 
 465                470                475                480
Arg Thr Ala Ile Glu Ala Phe Asn Glu Thr Ile Lys Ile Phe Glu Glu 
                 485                490                495
Gln Cys Gln Thr Gln Glu Arg Tyr Ser Lys Glu Tyr Ile Glu Lys Phe 
             500                505                510
Lys Arg Glu Gly Asn Glu Lys Glu Ile Gln Arg Ile Met His Asn Tyr 
         515                520                525
Asp Lys Leu Lys Ser Arg Ile Ser Glu Ile Ile Asp Ser Arg Arg Arg 
     530                535                540
Leu Glu Glu Asp Leu Lys Lys Gln Ala Ala Glu Tyr Arg Glu Ile Asp 
 545                550                555                560
Lys Arg Met Asn Ser Ile Lys Pro Asp Leu Ile Gln Leu Arg Lys Thr 
                 565                570                575
Arg Asp Gln Tyr Leu Met Trp Leu Thr Gln Lys Gly Val Arg Gln Lys 
             580                585                590
Lys Leu Asn Glu Trp Leu Gly Asn Glu Asn Thr Glu Asp Gln Tyr Ser 
         595                600                605
Leu Val Glu Asp Asp Glu Asp Leu Pro His His Asp Glu Lys Thr Trp 
     610                615                620
Asn Val Gly Ser Ser Asn Arg Asn Lys Ala Glu Asn Leu Leu Arg Gly 
 625                630                635                640
Lys Arg Asp Gly Thr Phe Leu Val Arg Glu Ser Ser Lys Gln Gly Cys 
                 645                650                655
Tyr Ala Cys Ser Val Val Val Asp Gly Glu Val Lys His Cys Val Ile 
             660                665                670
Asn Lys Thr Ala Thr Gly Tyr Gly Phe Ala Glu Pro Tyr Asn Leu Tyr 
         675                680                685
Ser Ser Leu Lys Glu Leu Val Leu His Tyr Gln His Thr Ser Leu Val 
     690                695                700
Gln His Asn Asp Ser Leu Asn Val Thr Leu Ala Tyr Pro Val Tyr Ala 
 705                710                715                720
Gln Gln Arg Arg 
                 725



<210> 2143
<211> 2169
<212> DNA
<213> Rattus norvegicus
<308> D64046
<400> 2143

atggcaggt  ctgaaggct  ccagtacag  gctgtatac  cattccgcc  ggagcggcc  60
gaggacctg  agcttcttc  tggtgacct  ctggtggtg  gccgggtgg  tctgcaggc  120
ctaggtgtg  ctgatggag  agagcgctg  ccacacaac  tgggctgga  gcctggctt  180
aatgagcgc  cccgacagc  aggggactt  cctggaaca  atgtggagt  cctaggacc  240
gtggctctg  ctcgaccag  ccctcgccc  cgggggccc  gtccattgc  tgccaggcc  300
ttggatgga  cttctgagt  aggtcacac  ctggcaagc  tggcagagc  gttctcccc  360
cctgagtct  cgcccccga  tctggtgaa  ctgatagaa  ccattgagc  agcagagct  420
gacagtgaa  tttacagta  gccggagct  cccgcacca  ggacagact  gtccctgag  480
gacttggag  agtgggacc  caccacctt  tacgatgct  ttaagggct  cctgctggc  540
ttgcctgca  ctgtggtga  tcctgaggc  gcatcggag  cttatcggg  gatgcggga  600
gttacgggg  ctgtggggc  ggtgctgga  cccccaacg  tgccgttgc  ccaggccct  660
actctgcgg  tcctgctgc  gcacctggg  cgcgtggcc  gcagagcac  ctcaccagc  720
acagctgtc  acgcactgg  cagtgcctt  gggccgctg  tgctgcgtg  gcctccgcc  780
gggggcgag  gtgatggga  tgagcctgc  cctgacttc  ctgtgctgc  tctagagag  840
ctggtgcag  agcatgtgg  tgagcaaga  accgccccg  cagcactgc  acccaaacc  900
tctaaggta  agccggcac  cacagccct  gccaatgga  ggagtacac  ctcgcttca  960
gatgcagag  ggtactggg  ggacatttc  agggaagag  tgaatgaga  gctccgaga  1020
acacctgat  gtaccttct  agtccgaga  gcatccagc  agatccaag  agagtacac  1080
ctcaccctc  ggaaaggcg  gaacaacaa  ctaatcaaa  tcttccacc  ggacggtca  1140
tatggcttc  cagagcccc  taccttctg  tccgtggta  agctcatct  ccactaccg  1200
catgagtca  tggcccagt  caacgccaa  ctggacacg  gccttctct  ccctgtgtc  1260
aagtaccag  aagaccagg  ggtgaagga  gacagtgta  aggctgtgg  tgcccagct  1320
aaggtctac  accagcagt  ccaggacaa  agccgcgag  atgaccagc  ctatgagga  1380
tacacacga  cctcccagg  gcttcagat  aagcgcaca  ccatagagg  cttcaacga  1440
accatcttg  tcttcgaag  acagggcca  acacaggag  agtgcagca  ggagtattt  1500
gagcgcttc  ggcgagagg  caatgagaa  gagatgcag  ggatcctgc  gaactcgga  1560
cgactcaag  ctcgaatcg  ggagataca  gaaagccgc  cgaagctgg  gcaggatct  1620
cgggcgcag  cctcggaca  tcgagagat  gacaagcgc  tgaacagcc  caagcctga  1680
ctcatgcag  tgcgcaaga  cagggacca  tacctcgtg  ggctcaccc  gaaaggtgc  1740
cgacagagg  agatcaacg  gtggctggg  atcaagaat  agactgagg  ccagtattc  1800
ctgatggag  atgaggacg  cctccccca  catgaggag  gcacgtggt  cgtgggcaa  1860
atcaaccgc  cacaggcgg  ggagatgct  agtgccaaa  gagacggga  cttcctcat  1920
cgggagagc  gccagcggg  ctgttacgc  tgctctgtg  tggtggatg  cgacacgaa  1980
cactgtgtc  tctaccgca  agccactgg  tttggcttc  cagagccct  taacctgta  2040
ggatccctg  aggagctgg  attgcacta  cagcacgca  cacttgtgc  gcacaatga  2100
gcgctcacc  tcaccctcg  acaccctgt  cgtgccccc  ggcctggcc  gccccctgc  2160
gcacgctga  2169



<210> 2144
<211> 722
<212> PRT
<213> Rattus norvegicus
<308> Q63788
<400> 2144

Met Ala Gly Ala Glu Gly Phe Gln Tyr Arg Ala Val Tyr Pro Phe Arg 
  1               5                  10                  15
Arg Glu Arg Pro Glu Asp Leu Glu Leu Leu Pro Gly Asp Leu Leu Val 
             20                  25                  30
Val Ser Arg Val Ala Leu Gln Ala Leu Gly Val Ala Asp Gly Gly Glu 
         35                  40                  45
Arg Cys Pro His Asn Val Gly Trp Met Pro Gly Phe Asn Glu Arg Thr 
     50                  55                  60
Arg Gln Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Phe Leu Gly Pro 
 65                  70                  75                  80
Val Ala Leu Ala Arg Pro Gly Pro Arg Pro Arg Gly Pro Arg Pro Leu 
                 85                  90                  95
Pro Ala Arg Pro Leu Asp Gly Pro Ser Glu Ser Gly His Thr Leu Ala 
             100                105                110
Ser Leu Ala Glu Gln Phe Ser Pro Pro Glu Ser Ala Pro Pro Ile Leu 
         115                120                125
Val Lys Leu Ile Glu Ala Ile Glu Gln Ala Glu Leu Asp Ser Glu Phe 
     130                135                140
Tyr Ser Arg Pro Glu Leu Pro Ala Pro Arg Thr Asp Trp Ser Leu Ser 
 145                150                155                160
Asp Leu Glu Gln Trp Asp Arg Thr Thr Leu Tyr Asp Ala Val Lys Gly 
                 165                170                175
Phe Leu Leu Ala Leu Pro Ala Ala Val Val Thr Pro Glu Ala Ala Ser 
             180                185                190
Glu Ala Tyr Arg Ala Met Arg Glu Val Thr Gly Pro Val Gly Leu Val 
         195                200                205
Leu Glu Pro Pro Thr Leu Pro Leu His Gln Ala Leu Thr Leu Arg Phe 
     210                215                220
Leu Leu Gln His Leu Gly Arg Val Ala Arg Arg Ala Pro Ser Pro Ala 
 225                230                235                240
Thr Ala Val His Ala Leu Ala Ser Ala Phe Gly Pro Leu Leu Leu Arg 
                 245                250                255
Ala Pro Pro Pro Gly Gly Glu Gly Asp Gly Ser Glu Pro Ala Pro Asp 
             260                265                270
Phe Pro Val Leu Leu Leu Glu Arg Leu Val Gln Glu His Val Asp Glu 
         275                280                285
Gln Asp Thr Ala Pro Pro Ala Leu Pro Pro Lys Pro Ser Lys Val Lys 
     290                295                300
Pro Ala Pro Thr Ala Leu Ala Asn Gly Gly Ser Thr Pro Ser Leu Gln 
 305                310                315                320
Asp Ala Glu Trp Tyr Trp Gly Asp Ile Ser Arg Glu Glu Val Asn Glu 
                 325                330                335
Arg Leu Arg Asp Thr Pro Asp Gly Thr Phe Leu Val Arg Asp Ala Ser 
             340                345                350
Ser Lys Ile Gln Gly Glu Tyr Thr Leu Thr Leu Arg Lys Gly Gly Asn 
         355                360                365
Asn Lys Leu Ile Lys Val Phe His Arg Asp Gly His Tyr Gly Phe Ser 
     370                375                380
Glu Pro Leu Thr Phe Cys Ser Val Val Glu Leu Ile Ser His Tyr Arg 
 385                390                395                400
His Glu Ser Leu Ala Gln Tyr Asn Ala Lys Leu Asp Thr Arg Leu Leu 
                 405                410                415
Tyr Pro Val Ser Lys Tyr Gln Gln Asp Gln Val Val Lys Glu Asp Ser 
             420                425                430
Val Glu Ala Val Gly Ala Gln Leu Lys Val Tyr His Gln Gln Tyr Gln 
         435                440                445
Asp Lys Ser Arg Glu Tyr Asp Gln Leu Tyr Glu Glu Tyr Thr Arg Thr 
     450                455                460
Ser Gln Glu Leu Gln Met Lys Arg Thr Ala Ile Glu Ala Phe Asn Glu 
 465                470                475                480
Thr Ile Leu Ile Phe Glu Glu Gln Gly Gln Thr Gln Glu Lys Cys Ser 
                 485                490                495
Lys Glu Tyr Leu Glu Arg Phe Arg Arg Glu Gly Asn Glu Lys Glu Met 
             500                505                510
Gln Arg Ile Leu Leu Asn Ser Glu Arg Leu Lys Ser Arg Ile Ala Glu 
         515                520                525
Ile His Glu Ser Arg Thr Lys Leu Glu Gln Asp Leu Arg Ala Gln Ala 
     530                535                540
Ser Asp Asn Arg Glu Ile Asp Lys Arg Met Asn Ser Leu Lys Pro Asp 
 545                550                555                560
Leu Met Gln Leu Arg Lys Ile Arg Asp Gln Tyr Leu Val Trp Leu Thr 
                 565                570                575
Gln Lys Gly Ala Arg Gln Arg Lys Ile Asn Glu Trp Leu Gly Ile Lys 
             580                585                590
Asn Glu Thr Glu Asp Gln Tyr Ser Leu Met Glu Asp Glu Asp Ala Leu 
         595                600                605
Pro His His Glu Glu Arg Thr Trp Tyr Val Gly Lys Ile Asn Arg Thr 
     610                615                620
Gln Ala Glu Glu Met Leu Ser Ala Lys Arg Asp Gly Thr Phe Leu Ile 
 625                630                635                640
Arg Glu Ser Ser Gln Arg Gly Cys Tyr Ala Cys Ser Val Val Val Asp 
                 645                650                655
Gly Asp Thr Lys His Cys Val Ile Tyr Arg Thr Ala Thr Gly Phe Gly 
             660                665                670
Phe Ala Glu Pro Tyr Asn Leu Tyr Gly Ser Leu Lys Glu Leu Val Leu 
         675                680                685
His Tyr Gln His Ala Ser Leu Val Gln His Asn Asp Ala Leu Thr Val 
     690                695                700
Thr Leu Ala His Pro Val Arg Ala Pro Gly Pro Gly Pro Pro Pro Ala 
 705                710                715                720
Ala Arg 
                 725



<210> 2145
<211> 3201
<212> DNA
<213> Homo sapiens
<308> X80907
<400> 2145

caactccct  ccaccagct  acgaatggt  gacccagtg  cgagtggcc  ttgtaaggg  60
catggaata  tttgaagcg  ggcatgagc  gcccctgtg  tcgcctgtg  ctgctggag  120
tagaggtcc  agcacccca  gccaaccca  cggaccctc  cagccctgc  tcaaccaat  180
gggccagtg  ggctccaag  agccaacct  accatccag  ccccacccc  ctcacgcgg  240
catggcggg  cctgagggc  tccagtacc  cgctctgta  ccgttccgc  gggagcggc  300
ggaggacct  gagctgctg  ccggcgacg  gctggtagt  agccgggcg  ccttgcagg  360
gctgggcgt  gccgagggt  gcgagcgct  cccacagag  gtgggctgg  tgcccggcc  420
caacgagcg  acacggcag  gaggtgact  ccctggcac  tatgtggag  tcctggggc  480
cgtggccct  gcccggccc  gccctcgcc  acggggccc  cgcccactg  ccgccaggc  540
ccgtgatgg  gcccctgag  caggcctca  actccccga  ttgcccgag  agttctccc  600
acctgatgt  gctccccct  ttctggtga  gcttgtgga  gccattgaa  ggacagggc  660
ggacagcga  tctcactac  gcccggagc  gcccgcacc  cgtacagac  ggtccctga  720
cgacgtgga  cagtgggac  cggcagccc  ggctgacgg  attaagagc  tcctgctgg  780
actgcccgc  ccgctcgtg  cccccgagg  ctcggccga  gcgcgccgg  ccctgcggg  840
ggccgcggg  cccgtgggg  cggcgctgg  gccaccgac  ctgccgctg  accgcgcgc  900
cacgctgcg  ttcctgctc  agcacctgg  ccgcgtggc  cgccgcgcc  cggccctgg  960
tcccgcggt  cgggccctg  gcgccacct  tgggccgct  ctcctgcgc  cgccgccgc  1020
gccgtcctc  ccgccgcca  ggggcgctc  cgacgggag  gagcccagc  ctgacttcc  1080
ggcgctgct  gtggagaag  tgcttcagg  acacttgga  gagcaggag  ttgcgcccc  1140
agcgctgcc  cctaaaccc  ccaaggcaa  gccggcccc  acagtcctg  ccaatggag  1200
gagcccacc  tccctgcag  atgctgagt  gtactgggg  gacatttca  gggaggagg  1260
gaacgagaa  ctccgggac  ctcccgatg  caccttcct  gtccgagat  cttctagca  1320
gatccaggg  gagtacacg  tgaccctca  gaaaggcgg  aacaataag  tgatcaagg  1380
cttccaccg  gatgggcac  atggcttct  agagccact  accttctgc  ccgttgtgg  1440
cctcatcaa  cactaccgc  acgagtctc  ggcccagta  aatgccaag  tggacacac  1500
gctcctcta  cctgtgtcc  aataccagc  ggaccagat  gtcaaggag  acagcgtgg  1560
ggcagtggg  gcccagctt  aggtctatc  ccagcagta  caggacaag  gccgcgagt  1620
tgaccagct  tatgaagag  acacacgga  ctcccagga  ctgcagatg  agcgtactg  1680
aattgaggc  ttcaatgag  ctatcaaga  ctttgaaga  cagggccag  ctcaagaga  1740
atgcagcaa  gaatacctg  agcgcttcc  gcgtgaggg  aacgagaaa  agatgcaaa  1800
gatcctgct  aactccgag  ggctcaagt  ccgcattgc  gagatccat  agagccgca  1860
gaagctgga  cagcagctg  gggcccagg  ctcggacaa  agagagatc  acaagcgca  1920
gaacagcct  aagccggac  tcatgcagc  gcgcaagat  cgagaccag  acctcgtgt  1980
gctcaccca  aaaggcgcc  ggcagaaga  aatcaacga  tggctgggg  ttaaaaatg  2040
gactgagga  cagtacgca  tcatggagg  cgaggacga  ctcccgcac  acgaggaac  2100
cacttggta  gtgggcaag  tcaaccgca  gcaggcaga  gagatgctg  gcggcaagc  2160
ggatggcac  ttcctcatc  gcgagagca  ccagcgggg  tgctacgcc  gctccgtgg  2220
agtggacgg  gacaccaag  actgcgtca  ctaccgcac  gccaccggc  tcggcttcg  2280
ggagcccta  aacctgtac  ggtcgctga  ggagctggt  ctgcactac  agcacgcct  2340
gctggtgca  cacaacgac  cgctcactg  caccctggc  cacccagtg  gcgccccgg  2400
ccccggccc  ccgcctgcc  cccgctgag  accgaggac  cgccccaag  agagccgcc  2460
ctgggcccg  ctgcgccgg  ggctgcggc  gcgggagcc  cggaccaag  ccagccaca  2520
ccaggggtc  tcatttctc  ggctctggc  cttgtttgg  gttctctca  cctctttct  2580
tttccttcc  tcccccatt  tccagatct  cctctgtct  cttttctct  tctttcttg  2640
cccctgtct  tctccatgt  gggggtcct  actccccca  cccatatct  cgtgtcctc  2700
gggcattgc  ctctccatg  ctctggtca  cctgaccct  tgccctgcc  accgcaggt  2760
ccccggggt  ccggaagcc  cttctggct  cacctgcca  gtttacaga  ggcccctgg  2820
ctgcgcggc  ccagcctgg  caccctgat  tttaagcca  agacctggg  tcagggcag  2880
aaggaactt  actctgctg  ttccgagaa  ctcggccgt  acattcggg  ccgggcggg  2940
cccgcccca  agactccaa  ttcccctcc  aaccccgaa  tgaaacccg  caccgggtt  3000
ccccacaag  gggccgctg  gagaagttc  cccaccccc  aaaaaataa  taaactcgc  3060
ggccaggca  ggtggctca  gcctgtaat  ccagcactt  gggaggcca  gacgggcgg  3120
tcttttgag  tcgggagtt  gaggccagc  tggccaaaa  ggcaaaacc  cgcatctac  3180
aaaatacaa  aattagccg  g  3201



<210> 2146
<211> 728
<212> PRT
<213> Homo sapiens
<308> O00459
<400> 2146

Met Ala Gly Pro Glu Gly Phe Gln Tyr Arg Ala Leu Tyr Pro Phe Arg 
  1               5                  10                  15
Arg Glu Arg Pro Glu Asp Leu Glu Leu Leu Pro Gly Asp Val Leu Val 
             20                  25                  30
Val Ser Arg Ala Ala Leu Gln Ala Leu Gly Val Ala Glu Gly Gly Glu 
         35                  40                  45
Arg Cys Pro Gln Ser Val Gly Trp Met Pro Gly Leu Asn Glu Arg Thr 
     50                  55                  60
Arg Gln Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Phe Leu Gly Pro 
 65                  70                  75                  80
Val Ala Leu Ala Arg Pro Gly Pro Arg Pro Arg Gly Pro Arg Pro Leu 
                 85                  90                  95
Pro Ala Arg Pro Arg Asp Gly Ala Pro Glu Pro Gly Leu Thr Leu Pro 
             100                105                110
Asp Leu Pro Glu Gln Phe Ser Pro Pro Asp Val Ala Pro Pro Leu Leu 
         115                120                125
Val Lys Leu Val Glu Ala Ile Glu Arg Thr Gly Leu Asp Ser Glu Ser 
     130                135                140
His Tyr Arg Pro Glu Leu Pro Ala Pro Arg Thr Asp Trp Ser Leu Ser 
 145                150                155                160
Asp Val Asp Gln Trp Asp Thr Ala Ala Leu Ala Asp Gly Ile Lys Ser 
                 165                170                175
Phe Leu Leu Ala Leu Pro Ala Pro Leu Val Thr Pro Glu Ala Ser Ala 
             180                185                190
Glu Ala Arg Arg Ala Leu Arg Glu Ala Ala Gly Pro Val Gly Pro Ala 
         195                200                205
Leu Glu Pro Pro Thr Leu Pro Leu His Arg Ala Leu Thr Leu Arg Phe 
     210                215                220
Leu Leu Gln His Leu Gly Arg Val Ala Arg Arg Ala Pro Ala Leu Gly 
 225                230                235                240
Pro Ala Val Arg Ala Leu Gly Ala Thr Phe Gly Pro Leu Leu Leu Arg 
                 245                250                255
Ala Pro Pro Pro Pro Ser Ser Pro Pro Pro Gly Gly Ala Pro Asp Gly 
             260                265                270
Ser Glu Pro Ser Pro Asp Phe Pro Ala Leu Leu Val Glu Lys Leu Leu 
         275                280                285
Gln Glu His Leu Glu Glu Gln Glu Val Ala Pro Pro Ala Leu Pro Pro 
     290                295                300
Lys Pro Pro Lys Ala Lys Pro Ala Pro Thr Val Leu Ala Asn Gly Gly 
 305                310                315                320
Ser Pro Pro Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly Asp Ile Ser 
                 325                330                335
Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Pro Asp Gly Thr Phe 
             340                345                350
Leu Val Arg Asp Ala Ser Ser Lys Ile Gln Gly Glu Tyr Thr Leu Thr 
         355                360                365
Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Val Phe His Arg Asp 
     370                375                380
Gly His Tyr Gly Phe Ser Glu Pro Leu Thr Phe Cys Ser Val Val Asp 
 385                390                395                400
Leu Ile Asn His Tyr Arg His Glu Ser Leu Ala Gln Tyr Asn Ala Lys 
                 405                410                415
Leu Asp Thr Arg Leu Leu Tyr Pro Val Ser Lys Tyr Gln Gln Asp Gln 
             420                425                430
Ile Val Lys Glu Asp Ser Val Glu Ala Val Gly Ala Gln Leu Lys Val 
         435                440                445
Tyr His Gln Gln Tyr Gln Asp Lys Ser Arg Glu Tyr Asp Gln Leu Tyr 
     450                455                460
Glu Glu Tyr Thr Arg Thr Ser Gln Glu Leu Gln Met Lys Arg Thr Ala 
 465                470                475                480
Ile Glu Ala Phe Asn Glu Thr Ile Lys Ile Phe Glu Glu Gln Gly Gln 
                 485                490                495
Thr Gln Glu Lys Cys Ser Lys Glu Tyr Leu Glu Arg Phe Arg Arg Glu 
             500                505                510
Gly Asn Glu Lys Glu Met Gln Arg Ile Leu Leu Asn Ser Glu Arg Leu 
         515                520                525
Lys Ser Arg Ile Ala Glu Ile His Glu Ser Arg Thr Lys Leu Glu Gln 
     530                535                540
Gln Leu Arg Ala Gln Ala Ser Asp Asn Arg Glu Ile Asp Lys Arg Met 
 545                550                555                560
Asn Ser Leu Lys Pro Asp Leu Met Gln Leu Arg Lys Ile Arg Asp Gln 
                 565                570                575
Tyr Leu Val Trp Leu Thr Gln Lys Gly Ala Arg Gln Lys Lys Ile Asn 
             580                585                590
Glu Trp Leu Gly Ile Lys Asn Glu Thr Glu Asp Gln Tyr Ala Leu Met 
         595                600                605
Glu Asp Glu Asp Asp Leu Pro His His Glu Glu Arg Thr Trp Tyr Val 
     610                615                620
Gly Lys Ile Asn Arg Thr Gln Ala Glu Glu Met Leu Ser Gly Lys Arg 
 625                630                635                640
Asp Gly Thr Phe Leu Ile Arg Glu Ser Ser Gln Arg Gly Cys Tyr Ala 
                 645                650                655
Cys Ser Val Val Val Asp Gly Asp Thr Lys His Cys Val Ile Tyr Arg 
             660                665                670
Thr Ala Thr Gly Phe Gly Phe Ala Glu Pro Tyr Asn Leu Tyr Gly Ser 
         675                680                685
Leu Lys Glu Leu Val Leu His Tyr Gln His Ala Ser Leu Val Gln His 
     690                695                700
Asn Asp Ala Leu Thr Val Thr Leu Ala His Pro Val Arg Ala Pro Gly 
 705                710                715                720
Pro Gly Pro Pro Pro Ala Ala Arg 
                 725



<210> 2147
<211> 2881
<212> DNA
<213> Rattus norvegicus
<308> D64050
<400> 2147

gttcttagt  gtactatca  taaccaggt  gcagtcggc  agctccaag  gactaaaca  60
agcttcagc  cgcaggctt  ctgattagt  caactagcc  tggtgaggg  gtaacaaga  120
gaacacaaa  ggaagccgg  tgcatcgca  cactcgaca  tgcaaatgg  tatagacaa  180
ctgaacata  ccttgcttc  gatcttccg  caaggagta  ctgcagccc  gggactctt  240
cctcagcaa  tacacatca  ccgcctcat  gaaaagaag  gccagattg  gttgtttgt  300
tctcccgga  accggaaac  aggagagcc  caggccctg  aggctgagg  agtactgcg  360
tcccttaat  tggatgttt  gcgtcagag  ttaccacag  ttggaatta  agacgtctc  420
cctgagaaa  atgttttac  agggcagca  gaagcggac  agatctgga  caaagaagg  480
ttttacgcc  tcgtcatct  cctcagcat  tttatcatt  tagtaacct  tttgatgat  540
atttatagg  taaaagaaa  gcttcagct  tccttacga  aagataaag  gaaaaacca  600
gagatccac  tatcgccca  tgcactcca  caagcacaa  cggaggcca  ggcagccca  660
agcatggtc  agcccgacc  ggcgccaaa  gtgctgaat  ttgttgtgg  ccctcaagg  720
caatgcact  ctgagattc  aaacaccgc  tccacttct  tctgccctt  tcccttcag  780
atgaagccc  taggactcc  ggagcgacg  ggttccaat  tatctctta  actggacat  840
agtagcctg  gcaacgtgg  accctttgt  gccgtctcc  ccccccggg  gaaggtagc  900
atggagtac  tgcagtcag  cagccgagt  ctcacaagg  cacagctga  ggacgtcgt  960
gcaagttcc  acctgcttc  aagtgaatt  atggaaata  caatgaact  tgtggatcc  1020
aaagaaatt  atattccac  tcatggaac  aaaaatcgt  ataagacca  tttgccaaa  1080
cccctcagc  gggtgtgct  aagaccaaa  aatataact  acccattga  tacttacat  1140
aatgctaat  acattcggg  ctacagtgg  aaggagaaa  ccttcattg  cacacaggg  1200
cccatgatc  acactgtga  tgacttctg  cagatggtt  ggcaagaag  cagtcctgt  1260
attgttatg  tcacgaaac  caaagagaa  aatgagaaa  gtgtgctct  ctggccaga  1320
aagagaggg  tttacggca  ggttgaggt  ctggtcatc  gtgtcaatg  atgtgataa  1380
tacaccatc  gcaacctcg  cttgaagcg  ggaagtcac  cccaacatg  gaagcatta  1440
tggtacact  catggcccg  tcacaagac  ccagacagt  cccagcccc  tctgcagct  1500
atgctggac  tagaggaag  cagactggc  tctgaaggc  gagggcctg  ggttgtcca  1560
tgcagtgca  ggattggga  aaccggatg  ttcatcgct  catccattg  ctgtcaaca  1620
ttgaaagaa  aaggagtcg  agatgcact  agtatcgtc  gccagcttc  tgtagacag  1680
ggtggaatg  tccaaacca  tgagcagta  gaatttgtg  accacgctc  gtgcctgtt  1740
gagagcaga  tttcgccag  aacggtcca  tgactctga  gatctacca  agcgtcaat  1800
tatcacggg  gattcgtca  gttacctac  gagggctcc  agaaggagc  ccccacgat  1860
gatgaggag  ctctaaagc  agcctgagg  gtggattgt  gaagctatg  taacttgaa  1920
gattgccac  tttgtgtat  ggactgtgt  ctaggcatc  ccctagtta  tccgaagga  1980
ctgtgctga  ggaggtgtg  cagtcctca  gcagcctga  gaggattct  ttttgtctg  2040
gtcgactct  acacagaac  tgtatgtgt  atattcaga  tctgtgctt  tggtgactg  2100
aggagctgc  gaagatatc  ttatcctgt  ttagatgct  taatgttca  aaagcctgt  2160
ttgtgactg  actgtcagc  gttcaactg  tcctgtatt  agtgctatt  cctatctca  2220
ttaccagag  cttgctgct  aagttgcaa  tgaccgaca  tggattttt  accatgacg  2280
tttttgttt  tgaaaaaaa  aaatcaaag  cagtaacta  tttatatgg  gatgtgtct  2340
gattatctc  aataagtgt  tatttatag  atctcctat  gatcaatta  agagcacaa  2400
gattgtcac  ggatatata  gtatatgta  attacaggt  tatgtacgc  tatatattc  2460
attattaag  atagaggta  ctcctgttt  acaactcta  ctactatat  tctacattg  2520
gacttgttt  actttaaaa  gggataaac  aatttatag  aactataaa  tatcaataa  2580
tttaaatac  catctctct  ttactaaga  gggattttt  aatatagtg  ctacttggt  2640
tctctctcc  agtaagaag  aggtgcctt  ggggatgct  caacctgtt  catccccga  2700
agtttttct  aggacaccg  catgcacgc  tgaccttaa  tttctaaaa  gttttcttc  2760
tcaagagac  aatgaaggc  agataaccg  actcagcaa  catgagatg  tctgctcag  2820
tgtgaattt  caatgcagc  aagttgact  tcgtactcc  aataaatga  tcttaacag  2880
c  2881



<210> 2148
<211> 535
<212> PRT
<213> Rattus norvegicus
<308> BAA19530
<400> 2148

Met Asp Ile Asp Lys Leu Asn Ile Thr Leu Leu Arg Ile Phe Arg Gln 
  1               5                  10                  15
Gly Val Ala Ala Ala Leu Gly Leu Leu Pro Gln Gln Val His Ile Asn 
             20                  25                  30
Arg Leu Ile Glu Lys Lys Ser Gln Ile Glu Leu Phe Val Ser Pro Gly 
         35                  40                  45
Asn Arg Lys Pro Gly Glu Pro Gln Ala Leu Gln Ala Glu Glu Val Leu 
     50                  55                  60
Arg Ser Leu Asn Val Asp Val Leu Arg Gln Ser Leu Pro Gln Phe Gly 
 65                  70                  75                  80
Ile Ile Asp Val Ser Pro Glu Lys Asn Val Leu Gln Gly Gln His Glu 
                 85                  90                  95
Ala Asp Lys Ile Trp Ser Lys Glu Gly Phe Tyr Ala Val Val Ile Phe 
             100                105                110
Leu Ser Ile Phe Ile Ile Ile Val Thr Cys Leu Met Ile Ile Tyr Arg 
         115                120                125
Leu Lys Glu Arg Leu Gln Leu Ser Leu Arg Gln Asp Lys Glu Lys Asn 
     130                135                140
Gln Glu Ile His Leu Ser Pro Ile Ala Leu Gln Gln Ala Gln Ser Glu 
 145                150                155                160
Ala Lys Ala Ala His Ser Met Val Gln Pro Asp Gln Ala Pro Lys Val 
                 165                170                175
Leu Asn Val Val Val Asp Pro Gln Gly Gln Cys Thr Pro Glu Ile Arg 
             180                185                190
Asn Thr Ala Ser Thr Ser Val Cys Pro Ser Pro Phe Arg Met Lys Pro 
         195                200                205
Ile Gly Leu Gln Glu Arg Arg Gly Ser Asn Val Ser Leu Thr Leu Asp 
     210                215                220
Met Ser Ser Leu Gly Asn Val Glu Pro Phe Val Ala Val Ser Thr Pro 
 225                230                235                240
Arg Glu Lys Val Ala Met Glu Tyr Leu Gln Ser Ala Ser Arg Val Leu 
                 245                250                255
Thr Arg Pro Gln Leu Arg Asp Val Val Ala Ser Ser His Leu Leu Gln 
             260                265                270
Ser Glu Phe Met Glu Ile Pro Met Asn Phe Val Asp Pro Lys Glu Ile 
         275                280                285
Asp Ile Pro Arg His Gly Thr Lys Asn Arg Tyr Lys Thr Ile Leu Pro 
     290                295                300
Asn Pro Leu Ser Arg Val Cys Leu Arg Pro Lys Asn Ile Thr Asp Pro 
 305                310                315                320
Leu Ser Thr Tyr Ile Asn Ala Asn Tyr Ile Arg Gly Tyr Ser Gly Lys 
                 325                330                335
Glu Lys Ala Phe Ile Ala Thr Gln Gly Pro Met Ile Asn Thr Val Asn 
             340                345                350
Asp Phe Trp Gln Met Val Trp Gln Glu Asp Ser Pro Val Ile Val Met 
         355                360                365
Ile Thr Lys Leu Lys Glu Lys Asn Glu Lys Cys Val Leu Tyr Trp Pro 
     370                375                380
Glu Lys Arg Gly Ile Tyr Gly Lys Val Glu Val Leu Val Ile Gly Val 
 385                390                395                400
Asn Glu Cys Asp Asn Tyr Thr Ile Arg Asn Leu Val Leu Lys Arg Gly 
                 405                410                415
Ser His Thr Gln His Val Lys His Tyr Trp Tyr Thr Ser Trp Pro Asp 
             420                425                430
His Lys Thr Pro Asp Ser Ala Gln Pro Leu Leu Gln Leu Met Leu Asp 
         435                440                445
Val Glu Glu Asp Arg Leu Ala Ser Glu Gly Arg Gly Pro Val Val Val 
     450                455                460
His Cys Ser Ala Gly Ile Gly Arg Thr Gly Cys Phe Ile Ala Thr Ser 
 465                470                475                480
Ile Gly Cys Gln Gln Leu Lys Glu Glu Gly Val Val Asp Ala Leu Ser 
                 485                490                495
Ile Val Cys Gln Leu Arg Val Asp Arg Gly Gly Met Val Gln Thr Ser 
             500                505                510
Glu Gln Tyr Glu Phe Val His His Ala Leu Cys Leu Phe Glu Ser Arg 
         515                520                525
Leu Ser Pro Glu Thr Val Gln 
     530                535



<210> 2149
<211> 2401
<212> DNA
<213> Homo sapiens
<308> U77917
<400> 2149

ggtagtttc  aagagagac  ctgagggat  tttagaaag  ctgggacct  cagatgcca  60
gtcaggcac  cttgctcct  cataggaga  taaataatc  cgatatata  ggatggcag  120
ctgttgtct  agatcagtt  gagaagcag  tctggcagc  gggggtgta  gtgtgttgc  180
ctacactga  tggaataag  ctaaaaata  gtttagtgt  tgataagaa  gccagtttt  240
tcaagctct  atttaacgt  ggactttct  ttttgcttt  aaagaaaaa  gttttacaa  300
ggcagcatg  agcggacaa  atctggagc  aagaaggat  ttatgctgt  gtcattttt  360
tcagcatct  tgttattat  gtaacgtgt  tgatgattc  ttacagatt  aaagaaaga  420
ttcagcttt  cttaagaca  gacaaagag  aaaaccagg  gatccacct  tcgcccatc  480
cattacagc  agcactgtc  gaggcaaag  cagtccaca  catggtcca  cctgagcag  540
ccccaaagg  actgaatgt  gtcgtggac  ctcaaggcc  aggtgctcc  gagatcaga  600
ctaccaccg  tacctctgt  tgcccttct  ctttcaaaa  gaagcccat  ggacttcaa  660
agagaagag  gtccaacgt  tctcttaca  tggacatga  tagcttggg  aacattgaa  720
cctttgtgt  tataccaac  ccacgggag  aggtagcaa  ggagtatct  cagtcagcc  780
gccgaattc  cacaaggtc  cagctgagg  acgtcgtgg  aagttcaca  ttactccaa  840
gtgaattca  ggaaatacc  atgaacttt  tggatccca  agaaattga  attccgcgt  900
atggaacta  aaatcgcta  aagaccatt  taccaaatc  cctcagcag  gtgtgttta  960
gaccaaaaa  tgtaaccga  tcattgagc  cctacatta  tgctaatta  attaggggc  1020
acagtggca  ggagaaagc  ttcattgcc  cgcagggcc  catgatcaa  accgtggat  1080
atttctggc  gatggtttg  caggaagac  gccctgtga  tgttatgat  acaaaactc  1140
aagaaaaaa  tgagaaatg  gtgctatac  ggccggaaa  gagagggat  tatggaaaa  1200
ttgaggttc  ggttatcag  gtaaatgaa  gtgataact  caccattcg  aaccttgtc  1260
taaagcaag  aagccacac  caacatgtg  agcattact  gtacacctc  tggcctgat  1320
acaagactc  agacagtgc  cagcccctc  tacagctca  gctggatgt  gaagaagac  1380
gacttgctt  ccagggccg  gggcctgtg  ttgtccact  cagtgcagg  ataggtaga  1440
cagggtgtt  tattgctac  tccattggc  gtcaacagc  gaaagaaga  ggagttgtg  1500
atgcactaa  cattgtctg  cagcttcgt  tggatagag  tggaatggt  caaaccagt  1560
agcagtatg  atttgtgca  catgctctg  gcctgtatg  gagcagact  tcagcagag  1620
ctgtccagt  agtcattga  gacttgtca  accatcaat  tcttggggt  attaatcaa  1680
ttacccacc  aaggcttct  gaaggagct  cctgcaatg  aaggaagga  aagctctga  1740
gcccatgta  ggcatggat  gtggaagac  gggcaacat  tttaagatt  ccagctcct  1800
gtgtatatg  atgcatttg  aagcatccc  caaattatt  tgaaggttt  ttgatgatg  1860
aggtatgat  ggtttatca  acagcctaa  gcagatttt  ttttgtctg  actgactct  1920
tctgccaca  agaatgtat  tatgtaata  tcagtaata  atgtcatca  gtgatgact  1980
gatgagctg  tgaagacat  cgtattatg  gttagatgc  ttaatgttt  caaaatctg  2040
cttgtgaat  gactgtcag  tgttaaact  ttcctgttt  gaagtgcta  tacctttct  2100
agttaccag  atcttgctg  taaagttgc  agtgattga  aatggattt  taacagaga  2160
gtctttgtt  ttgaaaaac  aaaatcaaa  acagtaact  ttttatatg  aaatgtgtc  2220
tgataatat  acctattaa  tgtgtattt  tagtccctc  tatcaaaca  ttacagagc  2280
caatgattg  cattgggta  atatgtatt  actctctat  attgggcat  aaggtggct  2340
ctgctccag  actctatcc  ctgtatttc  acatcgtga  tcattttac  ttaaaaggg  2400
a  2401



<210> 2150
<211> 657
<212> PRT
<213> Homo sapiens
<308> NP_002840
<400> 2150

Met Arg Arg Ala Val Cys Phe Pro Ala Leu Cys Leu Leu Leu Asn Leu 
  1               5                  10                  15
His Ala Ala Gly Cys Phe Ser Gly Asn Asn Asp His Phe Leu Ala Ile 
             20                  25                  30
Asn Gln Lys Lys Ser Gly Lys Pro Val Phe Ile Tyr Lys His Ser Gln 
         35                  40                  45
Asp Ile Glu Lys Ser Leu Asp Ile Ala Pro Gln Lys Ile Tyr Arg His 
     50                  55                  60
Ser Tyr His Ser Ser Ser Glu Ala Gln Val Ser Lys Arg His Gln Ile 
 65                  70                  75                  80
Val Asn Ser Ala Phe Pro Arg Pro Ala Tyr Asp Pro Ser Leu Asn Leu 
                 85                  90                  95
Leu Ala Met Asp Gly Gln Asp Leu Glu Val Glu Asn Leu Pro Ile Pro 
             100                105                110
Ala Ala Asn Val Ile Val Val Thr Leu Gln Met Asp Val Asn Lys Leu 
         115                120                125
Asn Ile Thr Leu Leu Arg Ile Phe Arg Gln Gly Val Ala Ala Ala Leu 
     130                135                140
Gly Leu Leu Pro Gln Gln Val His Ile Asn Arg Leu Ile Gly Lys Lys 
 145                150                155                160
Asn Ser Ile Glu Leu Phe Val Ser Pro Ile Asn Arg Lys Thr Gly Ile 
                 165                170                175
Ser Asp Ala Leu Pro Ser Glu Glu Val Leu Arg Ser Leu Asn Ile Asn 
             180                185                190
Val Leu His Gln Ser Leu Ser Gln Phe Gly Ile Thr Glu Val Ser Pro 
         195                200                205
Glu Lys Asn Val Leu Gln Gly Gln His Glu Ala Asp Lys Ile Trp Ser 
     210                215                220
Lys Glu Gly Phe Tyr Ala Val Val Ile Phe Leu Ser Ile Phe Val Ile 
 225                230                235                240
Ile Val Thr Cys Leu Met Ile Leu Tyr Arg Leu Lys Glu Arg Phe Gln 
                 245                250                255
Leu Ser Leu Arg Gln Asp Lys Glu Lys Asn Gln Glu Ile His Leu Ser 
             260                265                270
Pro Ile Thr Leu Gln Pro Ala Leu Ser Glu Ala Lys Thr Val His Ser 
         275                280                285
Met Val Gln Pro Glu Gln Ala Pro Lys Val Leu Asn Val Val Val Asp 
     290                295                300
Pro Gln Gly Arg Gly Ala Pro Glu Ile Arg Ala Thr Thr Ala Thr Ser 
 305                310                315                320
Val Cys Pro Ser Pro Phe Lys Met Lys Pro Ile Gly Leu Gln Glu Arg 
                 325                330                335
Arg Gly Ser Asn Val Ser Leu Thr Leu Asp Met Ser Ser Leu Gly Asn 
             340                345                350
Ile Glu Pro Phe Val Ser Ile Pro Thr Pro Arg Glu Lys Val Ala Met 
         355                360                365
Glu Tyr Leu Gln Ser Ala Ser Arg Ile Leu Thr Arg Ser Gln Leu Arg 
     370                375                380
Asp Val Val Ala Ser Ser His Leu Leu Gln Ser Glu Phe Met Glu Ile 
 385                390                395                400
Pro Met Asn Phe Val Asp Pro Lys Glu Ile Asp Ile Pro Arg His Gly 
                 405                410                415
Thr Lys Asn Arg Tyr Lys Thr Ile Leu Pro Asn Pro Leu Ser Arg Val 
             420                425                430
Cys Leu Arg Pro Lys Asn Val Thr Asp Ser Leu Ser Thr Tyr Ile Asn 
         435                440                445
Ala Asn Tyr Ile Arg Gly Tyr Ser Gly Lys Glu Lys Ala Phe Ile Ala 
     450                455                460
Thr Gln Gly Pro Met Ile Asn Thr Val Asp Asp Phe Trp Gln Met Val 
 465                470                475                480
Trp Gln Glu Asp Ser Pro Val Ile Val Met Ile Thr Lys Leu Lys Glu 
                 485                490                495
Lys Asn Glu Lys Cys Val Leu Tyr Trp Pro Glu Lys Arg Gly Ile Tyr 
             500                505                510
Gly Lys Val Glu Val Leu Val Ile Ser Val Asn Glu Cys Asp Asn Tyr 
         515                520                525
Thr Ile Arg Asn Leu Val Leu Lys Gln Gly Ser His Thr Gln His Val 
     530                535                540
Lys His Tyr Trp Tyr Thr Ser Trp Pro Asp His Lys Thr Pro Asp Ser 
 545                550                555                560
Ala Gln Pro Leu Leu Gln Leu Met Leu Asp Val Glu Glu Asp Arg Leu 
                 565                570                575
Ala Ser Gln Gly Arg Gly Pro Val Val Val His Cys Ser Ala Gly Ile 
             580                585                590
Gly Arg Thr Gly Cys Phe Ile Ala Thr Ser Ile Gly Cys Gln Gln Leu 
         595                600                605
Lys Glu Glu Gly Val Val Asp Ala Leu Ser Ile Val Cys Gln Leu Arg 
     610                615                620
Met Asp Arg Gly Gly Met Val Gln Thr Ser Glu Gln Tyr Glu Phe Val 
 625                630                635                640
His His Ala Leu Cys Leu Tyr Glu Ser Arg Leu Ser Ala Glu Thr Val 
                 645                650                655
Gln 
             660



<210> 2151
<211> 2129
<212> DNA
<213> Rattus norvegicus
<308> D78018
<400> 2151

ttggaaatg  gaacgcaag  agcaggctt  atttttttt  cctcccccc  ctcctagct  60
tctcctcct  tctctccct  tcgcaccca  actcacgca  acctccagc  cgcacacag  120
cgtgcacgc  ccccccgcc  cccggcagt  atgtattct  cgctctgtc  cacccagga  180
gagtttcat  ctttcattg  agcacttct  ccccatgtc  gcgccttcg  ctacacatg  240
ttcaacctg  aggcccgaa  gcggaaata  ttcaaaaag  atgagaagc  catgtcgaa  300
gaagaggag  gggctgtga  ggatgaact  ctaagtgag  agcctgagg  caagcaaaa  360
tgggcttcc  gacttctgg  caagttacg  aaagatatc  gacccgagt  ccgagagga  420
tttgttctt  cagttacag  gaaaaaacc  ccatgctgt  ttctttcca  cccagacca  480
aaaggcaag  tgcggagaa  tgactgcct  cgccaggca  ataaagtat  gaggttgga  540
ctcgtcatg  tgatcttgt  caaaggtat  ccgctggaa  gtactgatg  tgaacgcct  600
gtgaagtcc  cacagtgct  gaatccagg  ctctgtgtc  agccccatc  cataggggt  660
tctgtaaag  aactcgatt  atatttggc  tactttgta  atgcagcag  acatttggg  720
ttccaggac  gcttcgtca  atcaggtgt  ttcagtgtg  ctgagctag  aagagtgtc  780
caaacacca  tagctgcag  aaccggccc  aatttttct  tctctgatt  ggaaagttc  840
tcatactac  gcatgagtc  aggagcaat  aggaggtct  tacccagca  atcctctac  900
agctctacc  agcgcctca  gtctgtgga  gacgaaatg  acagtcctg  tgaagaacc  960
ttttacaca  gccaagggc  ctccccagg  agtggcagc  agtccagcg  atggcatga  1020
gtagagcca  gcatgccat  tccaaccac  ctgaagaag  ctgagaagt  tggtttcag  1080
agcccctcc  cttcgcaga  ctcctccct  ggaacagca  tcacacagc  tcaccgacc  1140
gtcataaca  gaccgagag  aagcccaca  gcgacgcca  cgactctcc  ctttccaac  1200
tcacctatc  tccagcagc  tgggcctta  ttctcacac  cagccatcc  ttaccaccc  1260
caggagacg  tgaaggagt  tgtccaact  gtctgcccc  atgctggtc  gcaagctgg  1320
caggtgggg  tcctcaatc  caatggaag  agtcaaggc  aggtgcaca  cccattcct  1380
cccacccca  tgttgccgc  gccaccgcc  ccaccgatg  ccaggcctg  gcctctgcc  1440
atgccagac  ccaagcctc  aaccacatc  acagaaggc  gtgcagcct  ccccacctc  1500
ccgacctac  cgacaccca  cacctcccc  gcaaaccga  tcgtcagtg  tggaccacg  1560
gatccaagc  ttgtaaata  ccctcaaca  acacagtcc  ggtacctgg  ataaaagtt  1620
cagcgtccc  ccatcctcc  gacagacca  ctgacccct  ctcaactct  taacatgga  1680
gcaacctca  cccggcgca  ttacaactt  actgtcagt  gaaggggag  gacaccaac  1740
cgaatcaac  tgtacatgg  aacagcgaa  gtcgtggtc  aacagcaaa  gccataact  1800
ttcgggatt  ttttttttt  tttaatact  tagggactg  cgtaatttc  catatggtg  1860
tggaaatgg  tgggctgtg  gacatttga  gtgttccag  ggtggtgtg  gcagtaggt  1920
aagcggctg  taggggatg  gccttgctc  cgaacttcc  gttgtaaca  ttgtgagcc  1980
ggccttttc  cagtatttc  agaatttgc  cgcgcaggt  tgtgaccct  ccggagcac  2040
tggagacac  tggagaatg  aatctttcg  agtagctaa  atctgtgat  tgtaactta  2100
aggacactc  aagggcaat  ttttttggg  2129



<210> 2152
<211> 509
<212> PRT
<213> Rattus norvegicus
<308> P09414
<400> 2152

Met Tyr Ser Pro Leu Cys Leu Thr Gln Asp Glu Phe His Pro Phe Ile 
  1               5                  10                  15
Glu Ala Leu Leu Pro His Val Arg Ala Phe Ala Tyr Thr Trp Phe Asn 
             20                  25                  30
Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg Met 
         35                  40                  45
Ser Lys Glu Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Ser Glu Lys 
     50                  55                  60
Pro Glu Val Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu Arg 
 65                  70                  75                  80
Lys Asp Ile Arg Pro Glu Tyr Arg Glu Asp Phe Val Leu Thr Val Thr 
                 85                  90                  95
Gly Lys Lys Pro Pro Cys Cys Val Leu Ser Asn Pro Asp Gln Lys Gly 
             100                105                110
Lys Met Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp Arg 
         115                120                125
Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu Ser 
     130                135                140
Thr Asp Gly Glu Arg Leu Val Lys Ser Pro Gln Cys Ser Asn Pro Gly 
 145                150                155                160
Leu Cys Val Gln Pro His His Ile Gly Val Ser Val Lys Glu Leu Asp 
                 165                170                175
Leu Tyr Leu Ala Tyr Phe Val His Ala Ala Asp Ser Ser Gln Ser Glu 
             180                185                190
Ser Pro Ser Gln Pro Ser Asp Ala Asp Ile Lys Asp Gln Pro Glu Asn 
         195                200                205
Gly His Leu Gly Phe Gln Asp Ser Phe Val Thr Ser Gly Val Phe Ser 
     210                215                220
Val Thr Glu Leu Val Arg Val Ser Gln Thr Pro Ile Ala Ala Gly Thr 
 225                230                235                240
Gly Pro Asn Phe Ser Leu Ser Asp Leu Glu Ser Ser Ser Tyr Tyr Ser 
                 245                250                255
Met Ser Pro Gly Ala Met Arg Arg Ser Leu Pro Ser Thr Ser Ser Thr 
             260                265                270
Ser Ser Thr Lys Arg Leu Lys Ser Val Glu Asp Glu Met Asp Ser Pro 
         275                280                285
Gly Glu Glu Pro Phe Tyr Thr Gly Gln Gly Arg Ser Pro Gly Ser Gly 
     290                295                300
Ser Gln Ser Ser Gly Trp His Glu Val Glu Pro Gly Met Pro Ser Pro 
 305                310                315                320
Thr Thr Leu Lys Lys Ser Glu Lys Ser Gly Phe Ser Ser Pro Ser Pro 
                 325                330                335
Ser Gln Thr Ser Ser Leu Gly Thr Ala Phe Thr Gln His His Arg Pro 
             340                345                350
Val Ile Thr Gly Pro Arg Ala Ser Pro His Ala Thr Pro Ser Thr Leu 
         355                360                365
His Phe Pro Thr Ser Pro Ile Ile Gln Gln Pro Gly Pro Tyr Phe Ser 
     370                375                380
His Pro Ala Ile Arg Tyr His Pro Gln Glu Thr Leu Lys Glu Phe Val 
 385                390                395                400
Gln Leu Val Cys Pro Asp Ala Gly Gln Gln Ala Gly Gln Val Gly Phe 
                 405                410                415
Leu Asn Pro Asn Gly Ser Ser Gln Gly Lys Val His Asn Pro Phe Leu 
             420                425                430
Pro Thr Pro Met Leu Pro Pro Pro Pro Pro Pro Pro Met Ala Arg Pro 
         435                440                445
Val Pro Leu Pro Met Pro Asp Thr Lys Pro Pro Thr Thr Ser Thr Glu 
     450                455                460
Gly Gly Ala Ala Ser Pro Thr Ser Pro Thr Tyr Ser Thr Pro Ser Thr 
 465                470                475                480
Ser Pro Ala Asn Arg Phe Val Ser Val Gly Pro Arg Asp Pro Ser Phe 
                 485                490                495
Val Asn Ile Pro Gln Gln Thr Gln Ser Trp Tyr Leu Gly 
             500                505



<210> 2153
<211> 3206
<212> DNA
<213> Rattus norvegicus
<308> D78303
<400> 2153

gtttcgcgc  ggaagcagg  tccatttta  cgccgcccg  cgtcgccat  tgtttctct  60
tcctccccc  tgtctctgg  gtggccgaa  ccccaacag  aagattgaa  cccgcgctg  120
ccgaggtca  gcgggaaga  aaccagagg  cgggaggaa  ggtgctcgt  ggagctgag  180
ggagcaggt  aggtcgaag  gcgcggccc  ccggacgga  tgacggacg  actcgtgcg  240
ctgcggccg  ggctgcggc  cgccgcgcg  ctcgcttcc  ggcggcggt  gcggcggcg  300
aagccggag  gcagccatg  cggccgaca  ccgggagga  aaagatggg  aacttaatg  360
tttagatga  attttgact  aagtaccag  acaggatga  gaactgtat  atccagaga  420
tgaacaaga  aaaaatgag  aaaaaggat  aaaaagaaa  agtgaaaga  tggaatcta  480
tgacaccaa  cgacagaag  cttctatcc  ttcaagaca  ctgatttct  agccactaa  540
ctcatctgt  agcaataat  aaagaatag  tagtacaaa  ggaaagtcg  ttacagaat  600
taaaaatga  gaatatcaa  gatctgaaa  gaacaagcg  ctagatgct  atcgaaaaa  660
tcgtctgtc  agcagttcc  ctagagaac  ttacaagag  caaccagaa  aaccttgtc  720
acggaaaag  gattctgaa  gaagggcca  gtctcctac  ccagatggt  ctgagagaa  780
tgggcttga  gttgataga  gtgcaagca  atccagcca  tcttcaaag  aagagggga  840
ctctgagga  tatggctct  accacgaga  aggaagcag  gcttcttct  aacagggca  900
caacactga  aatgaggag  aaggagggg  agaagatgt  gaggaagat  aagaggtag  960
tgaagatgg  gatgatgat  aggaagtgg  tgaagatgc  gaggaggag  aggacgagg  1020
agaagatga  gaggaggag  atgaggaag  agaagagga  gaggaagaa  aatatgaac  1080
ggatgagag  gatcagaag  aagaaggga  tgattatga  acccgtagt  aggccagtg  1140
ttctggttc  gagtctgtt  ccttcacag  tggatctgt  aggtctggt  caggaacag  1200
tggatcaga  gagaaaaag  aggaaagga  gagagctcg  ggcatatca  ccattgtct  1260
tgatagaag  ggcagttct  catcagagt  atatgcaga  caaaccagt  aactcaaat  1320
tgtccttca  gatgcaaga  ttttcctca  aaagagtaa  aaccatgag  atgtgtctc  1380
tgccaaagc  aagggtgta  ggtccacat  acctgtaaa  gagaagaaa  taaatcttg  1440
gtttagatc  gcaaggagt  ttatattaa  attttctgt  agggaaagt  gaaagtttc  1500
aggttttgc  agattgtca  cagaatcgc  tcatggtgg  tctcctata  attgggtgc  1560
tccagcagg  atgagtgct  aaatgcttg  aggtgtttt  aaaattgac  ggatttgca  1620
gcgtgaatt  ccctttact  agtcagctc  tctcaccaa  ccctggaat  aacataagc  1680
agtaaagat  ggacgtgat  gacaggaaa  tgaacttga  tgtggaacc  agctttgtc  1740
tctgtttcc  cctgatgaa  gtattgact  gtatcagct  attcataaa  tgcgtcaca  1800
gagaagaat  cattctcag  ctcgatcaa  aggacgtcc  tcccgtcga  aaccagtcc  1860
ggatgtggg  aggcgtcga  cagaagatt  tgatattca  aacagcaga  agaaaccaa  1920
gattgacta  ccccctgag  ttcaccaga  accagggta  ttaaaggat  cccgatacc  1980
ggaagttga  agacgattt  caggagttc  ccgagatgt  tttttaaat  ggtcctaca  2040
tgattatgt  agggaattt  ataacatgg  accaccgcc  ccttggcaa  gaatgcctc  2100
ttacccggg  atagaacag  ctccacacc  tccctacta  cagcaccat  ccccgcctc  2160
tcaagccca  cccccttac  caggacacc  tccggtacc  catgaagca  gatacagag  2220
taaacgagt  catgactat  atatgaggg  tgatgattt  cttcgccgc  cacaagccg  2280
tgtcagtgg  cggagaagt  gaccccgag  aagagatcg  gagcgagag  gagaccgcc  2340
tagagataa  agaagagat  gagagcgag  cagaggtcg  gatcgagaa  gagagagag  2400
aagaatatg  gatcgggac  gagaccgag  ggaaagagg  cgttatcga  gataatgtg  2460
tttttggaa  cactgactg  agataaaaa  tattgtatt  tttttgtgt  tgtttacaa  2520
tagtaaatt  attttcagc  gtctactta  agctcattg  gtagaagga  ttattatct  2580
ctttgttcc  agcatgcag  agaataaga  ctggaaaac  cagatccgc  aaaaaatgc  2640
cagttgaca  ttgagttga  acttttatt  gggcagaat  gaacagtcc  agaatgtag  2700
tattgattc  ttctccata  atgttcttt  tacagtgta  tcatcctag  gttattttg  2760
ttgtttgtt  tccttcttt  ggaccttgg  caatactgc  atagtattt  gctttgtgt  2820
tctataggt  gctgcacac  gttcagtaa  aataatgct  ctatcaagt  tgcagatat  2880
gagtatgat  gtttgacta  atggcagtg  tgtagcagc  tctcggttt  tcctcttcc  2940
tcctttttt  taaacctat  aatccactt  ttttttaag  cttcaatga  gagagcaat  3000
ttaagaaga  attgctatc  aatttttaa  ctttttaaa  aaaacgttc  tatgttcag  3060
agcatggtc  atgctattg  ttagccttc  ttccaaact  tacattggc  tggaatgtt  3120
agttttgcg  gtgtggcag  agaagataa  cccacattc  acattgcta  tgttttgta  3180
gaaataaat  ggtaaagat  gacact  3206



<210> 2154
<211> 712
<212> PRT
<213> Rattus norvegicus
<308> BAA23885
<400> 2154

Met Ala Ala Asp Ser Arg Glu Glu Lys Asp Gly Glu Leu Asn Val Leu 
  1               5                  10                  15
Asp Asp Ile Leu Thr Glu Val Pro Glu Gln Asp Asp Glu Leu Tyr Asn 
             20                  25                  30
Pro Glu Ser Glu Gln Asp Lys Asn Glu Lys Lys Gly Ser Lys Arg Lys 
         35                  40                  45
Ser Glu Arg Met Glu Ser Ile Asp Thr Lys Arg Gln Lys Pro Ser Ile 
     50                  55                  60
His Ser Arg Gln Leu Ile Ser Lys Pro Leu Ser Ser Ser Val Ser Asn 
 65                  70                  75                  80
Asn Lys Arg Ile Val Ser Thr Lys Gly Lys Ser Val Thr Glu Tyr Lys 
                 85                  90                  95
Asn Glu Glu Tyr Gln Arg Ser Glu Arg Asn Lys Arg Leu Asp Ala Asp 
             100                105                110
Arg Lys Ile Arg Leu Ser Ser Ser Ser Ser Arg Glu Pro Tyr Lys Ser 
         115                120                125
Gln Pro Glu Lys Pro Cys Leu Arg Lys Arg Asp Ser Glu Arg Arg Ala 
     130                135                140
Lys Ser Pro Thr Pro Asp Gly Ser Glu Arg Ile Gly Leu Glu Val Asp 
 145                150                155                160
Arg Arg Ala Ser Arg Ser Ser Gln Ser Ser Lys Glu Glu Gly Asn Ser 
                 165                170                175
Glu Glu Tyr Gly Ser Asp His Glu Thr Gly Ser Ser Ala Ser Ser Glu 
             180                185                190
Gln Gly Asn Asn Thr Glu Asn Glu Glu Glu Gly Gly Glu Glu Asp Val 
         195                200                205
Glu Glu Asp Glu Glu Val Asp Glu Asp Gly Asp Asp Asp Glu Glu Val 
     210                215                220
Asp Glu Asp Ala Glu Glu Glu Glu Asp Glu Glu Glu Asp Glu Glu Glu 
 225                230                235                240
Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Tyr Glu Gln Asp 
                 245                250                255
Glu Arg Asp Gln Lys Glu Glu Gly Asn Asp Tyr Asp Thr Arg Ser Glu 
             260                265                270
Ala Ser Asp Ser Gly Ser Glu Ser Val Ser Phe Thr Asp Gly Ser Val 
         275                280                285
Arg Ser Gly Ser Gly Thr Asp Gly Ser Asp Glu Lys Lys Lys Glu Arg 
     290                295                300
Lys Arg Ala Arg Gly Ile Ser Pro Ile Val Phe Asp Arg Ser Gly Ser 
 305                310                315                320
Ser Ala Ser Glu Ser Tyr Ala Asp Gln Thr Ser Lys Leu Lys Ser Val 
                 325                330                335
Leu Gln Asp Ala Arg Phe Phe Leu Ile Lys Ser Asn Asn His Glu Asn 
             340                345                350
Val Ser Leu Ala Lys Ala Lys Gly Val Trp Ser Thr Leu Pro Val Asn 
         355                360                365
Glu Lys Lys Leu Asn Leu Ala Phe Arg Ser Ala Arg Ser Val Ile Leu 
     370                375                380
Ile Phe Ser Val Arg Glu Ser Gly Lys Phe Gln Gly Phe Ala Arg Leu 
 385                390                395                400
Ser Ser Glu Ser His His Gly Gly Ser Pro Ile His Trp Val Leu Pro 
                 405                410                415
Ala Gly Met Ser Ala Lys Met Leu Gly Gly Val Phe Lys Ile Asp Trp 
             420                425                430
Ile Cys Arg Arg Glu Leu Pro Phe Thr Lys Ser Ala His Leu Thr Asn 
         435                440                445
Pro Trp Asn Glu His Lys Pro Val Lys Ile Gly Arg Asp Gly Gln Glu 
     450                455                460
Ile Glu Leu Glu Cys Gly Thr Gln Leu Cys Leu Leu Phe Pro Pro Asp 
 465                470                475                480
Glu Ser Ile Asp Leu Tyr Gln Leu Ile His Lys Met Arg His Lys Arg 
                 485                490                495
Arg Met His Ser Gln Pro Arg Ser Arg Gly Arg Pro Ser Arg Arg Glu 
             500                505                510
Pro Val Arg Asp Val Gly Arg Arg Arg Pro Glu Asp Tyr Asp Ile His 
         515                520                525
Asn Ser Arg Lys Lys Pro Arg Ile Asp Tyr Pro Pro Glu Phe His Gln 
     530                535                540
Arg Pro Gly Tyr Leu Lys Asp Pro Arg Tyr Gln Glu Val Asp Arg Arg 
 545                550                555                560
Phe Ser Gly Val Arg Arg Asp Val Phe Leu Asn Gly Ser Tyr Asn Asp 
                 565                570                575
Tyr Val Arg Glu Phe His Asn Met Gly Pro Pro Pro Pro Trp Gln Gly 
             580                585                590
Met Pro Pro Tyr Pro Gly Ile Glu Gln Pro Pro His His Pro Tyr Tyr 
         595                600                605
Gln His His Ala Pro Pro Pro Gln Ala His Pro Pro Tyr Ser Gly His 
     610                615                620
His Pro Val Pro His Glu Ala Arg Tyr Arg Asp Lys Arg Val His Asp 
 625                630                635                640
Tyr Asp Met Arg Val Asp Asp Phe Leu Arg Arg Thr Gln Ala Val Val 
                 645                650                655
Ser Gly Arg Arg Ser Arg Pro Arg Glu Arg Asp Arg Glu Arg Glu Arg 
             660                665                670
Asp Arg Pro Arg Asp Asn Arg Arg Asp Arg Glu Arg Asp Arg Gly Arg 
         675                680                685
Asp Arg Glu Arg Glu Arg Glu Arg Ile Cys Asp Arg Asp Arg Asp Arg 
     690                695                700
Gly Glu Arg Gly Arg Tyr Arg Arg 
 705                710



<210> 2155
<211> 383
<212> DNA
<213> Homo sapiens
<308> BF798521
<400> 2155

catataacc  gggcagcag  ccctactgc  ggatatcct  cctctggtc  tcctgtcag  60
cagcctgtg  tccagcagc  ggatatatt  agcagccat  accacagat  ccagcctgt  120
attagcgct  caggccact  tcactccag  caacctcag  atcgcccag  cccttctgt  180
cattacaat  cacatctaa  accaaccac  gccacaacc  gcgcagcag  caggttatc  240
agttatacc  aaccagcag  aagaaacca  ggattgact  tccccctga  tttcaccag  300
gaccagggt  tttaaagga  ccacgatac  aggaagtgg  cagacgatt  tcaggagtt  360
gccgagatg  gtgtacaaa  ggg  383



<210> 2156
<211> 971
<212> PRT
<213> Homo sapiens
<308> Q15032
<400> 2156

Met Arg Met Ser Asp Thr Val Thr Val Lys Asp Glu Thr Ala Thr Met 
  1               5                  10                  15
Lys Asp Leu Glu Ala Glu Val Lys Asp Thr Thr Arg Val Glu Asn Leu 
             20                  25                  30
Ile Lys Ser Glu Asn Tyr Gly Lys Ile Leu Val Glu Lys Asn Glu His 
         35                  40                  45
Cys Ile Glu Asn Asn Ile Asp Leu Gln Glu Lys Ile Gln Ile Gln Leu 
     50                  55                  60
Thr Gln Ser Phe Glu Lys Glu Glu Lys Pro Ser Lys Asp Glu Ala Glu 
 65                  70                  75                  80
Lys Glu Lys Ala Ser Asp Lys Leu Pro Arg Lys Met Leu Ser Arg Asp 
                 85                  90                  95
Ser Ser Gln Glu Tyr Thr Asp Ser Thr Gly Ile Asp Leu His Glu Phe 
             100                105                110
Leu Val Asn Thr Leu Lys Asn Asn Pro Arg Asp Arg Met Met Leu Leu 
         115                120                125
Lys Leu Glu Gln Glu Ile Leu Asp Phe Ile Gly Asn Asn Glu Ser Pro 
     130                135                140
Arg Lys Lys Phe Pro Pro Met Thr Ser Tyr His Arg Met Leu Leu His 
 145                150                155                160
Arg Val Ala Ala Tyr Phe Gly Leu Asp His Asn Val Asp Gln Ser Gly 
                 165                170                175
Lys Ser Val Ile Val Asn Lys Thr Ser Asn Thr Arg Ile Pro Asp Gln 
             180                185                190
Lys Phe Asn Glu His Ile Lys Asp Asp Lys Gly Glu Asp Phe Gln Lys 
         195                200                205
Arg Tyr Ile Leu Lys Arg Asp Asn Ser Ser Phe Asp Lys Asp Asp Asn 
     210                215                220
Gln Val Arg Ile Arg Leu Lys Asp Asp Arg Arg Ser Lys Ser Ile Glu 
 225                230                235                240
Glu Arg Glu Glu Glu Tyr Gln Arg Ala Arg Asp Arg Ile Phe Ser Gln 
                 245                250                255
Asp Ser Leu Cys Ser Gln Glu Asn Tyr Ile Ile Asp Lys Arg Leu Gln 
             260                265                270
Asp Glu Asp Ala Ser Ser Thr Gln Gln Arg Arg Gln Ile Phe Arg Val 
         275                280                285
Asn Lys Asp Ala Ser Gly Arg Ser Thr Asn Ser His Gln Ser Ser Thr 
     290                295                300
Glu Asn Glu Leu Lys Tyr Ser Glu Pro Arg Pro Trp Ser Ser Thr Asp 
 305                310                315                320
Ser Asp Ser Ser Leu Arg Asn Leu Lys Pro Ala Val Thr Lys Ala Ser 
                 325                330                335
Ser Phe Ser Gly Ile Ser Val Leu Thr Arg Gly Asp Ser Ser Gly Ser 
             340                345                350
Ser Lys Ser Ile Gly Arg Leu Ser Lys Thr Gly Gln Pro Phe Ile Asn 
         355                360                365
Pro Asp Gly Ser Pro Val Val Tyr Asn Pro Pro Met Thr Gln Gln Pro 
     370                375                380
Val Arg Ser Gln Val Pro Gly Pro Pro Gln Pro Pro Leu Pro Ala Pro 
 385                390                395                400
Pro Gln Gln Pro Ala Ala Asn His Ile Phe Ser Gln Gln Asp Asn Leu 
                 405                410                415
Gly Ser Gln Phe Ser His Met Ser Leu Ala Arg Gln Pro Ser Ala Asp 
             420                425                430
Gly Ser Asp Pro His Ala Ala Met Phe Gln Ser Thr Val Val Leu Gln 
         435                440                445
Ser Pro Gln Gln Ser Gly Tyr Ile Met Thr Ala Ala Pro Pro Pro His 
     450                455                460
Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro 
 465                470                475                480
Gly Gln Pro Val Pro Thr Ala Gly Tyr Pro Ala Ser Gly His Pro Val 
                 485                490                495
Ser Gln Pro Val Leu Gln Gln Gln Gly Tyr Ile Gln Gln Pro Ser Pro 
             500                505                510
Gln Met Pro Ala Cys Tyr Cys Ala Pro Gly His Tyr His Ser Ser Gln 
         515                520                525
Pro Gln Tyr Arg Pro Val Pro Ser Val His Tyr Asn Ser His Leu Asn 
     530                535                540
Gln Pro Leu Pro Gln Pro Ala Gln Gln Thr Gly Tyr Gln Val Ile Pro 
 545                550                555                560
Asn Gln Gln Gln Asn Tyr Gln Gly Ile Val Gly Val Gln Gln Pro Gln 
                 565                570                575
Ser Gln Ser Leu Val Ser Gly Gln Pro Asn Ser Ile Gly Asn Gln Ile 
             580                585                590
Gln Gly Val Val Ile Pro Tyr Thr Ser Val Pro Thr Tyr Gln Val Ser 
         595                600                605
Leu Pro Gln Gly Ser Gln Gly Ile Pro His Gln Thr Tyr Gln Gln Pro 
     610                615                620
Val Met Phe Pro Asn Gln Ser Asn Gln Gly Ser Met Pro Thr Thr Gly 
 625                630                635                640
Met Pro Val Tyr Tyr Ser Val Ile Pro Pro Gly Gln Gln Asn Asn Leu 
                 645                650                655
Ser Ser Ser Val Gly Tyr Leu Gln His Pro Gly Ser Glu Gln Val Gln 
             660                665                670
Phe Pro Arg Thr Thr Ser Pro Cys Ser Ser Gln Gln Leu Gln Gly His 
         675                680                685
Gln Cys Thr Ala Gly Pro Pro Pro Pro Pro Gly Gly Gly Met Val Met 
     690                695                700
Met Gln Leu Ser Val Pro Asn Asn Pro Gln Ser Cys Ala His Ser Pro 
 705                710                715                720
Pro Gln Trp Lys Gln Asn Lys Tyr Tyr Cys Asp His Gln Arg Gly Gln 
                 725                730                735
Lys Cys Val Glu Phe Ser Ser Val Asp Asn Ile Val Gln His Ser Pro 
             740                745                750
Gln Leu Ser Ser Pro Ile Ile Ser Pro Ala Gln Ser Pro Ala Pro Ala 
         755                760                765
Gln Leu Ser Thr Leu Lys Thr Val Arg Pro Ser Gly Pro Pro Leu Ser 
     770                775                780
Ile Met Pro Gln Phe Ser Arg Pro Phe Val Pro Gly Gln Gly Asp Ser 
 785                790                795                800
Arg Tyr Pro Leu Leu Gly Gln Pro Leu Gln Tyr Asn Pro Pro Ala Val 
                 805                810                815
Leu His Gly His Ile Pro Asn Gln Gln Gly Gln Pro Gly Ser Arg His 
             820                825                830
Gly Asn Arg Gly Arg Arg Gln Ala Lys Lys Ala Ala Ser Thr Asp Leu 
         835                840                845
Gly Ala Gly Glu Thr Val Val Gly Lys Val Leu Glu Ile Thr Glu Leu 
     850                855                860
Pro Asp Gly Ile Thr Arg Met Glu Ala Glu Lys Leu Phe Gly Glu Leu 
 865                870                875                880
Phe Lys Ile Gly Ala Lys Ile Arg Trp Leu Arg Asp Pro Gln Ser Gln 
                 885                890                895
Pro Arg Arg His Pro Leu Cys Cys Gly Ser Gly Asp Asn Thr Ala Asn 
             900                905                910
Pro Glu Arg Ser Lys Pro Ser Asp Leu Ala Ser Thr Tyr Thr Val Leu 
         915                920                925
Ala Thr Phe Pro Ser Ile Ser Ala Ala Gln Asn Ala Leu Lys Lys Gln 
     930                935                940
Ile Asn Ser Val Asn Lys Phe Lys Leu Arg Thr Ser Lys Lys His Tyr 
 945                950                955                960
Asp Phe His Ile Leu Glu Arg Ala Ser Ser Gln 
                 965                970



<210> 2157
<211> 1816
<212> DNA
<213> Rattus norvegicus
<308> D78308
<400> 2157

ccccctcgg  ccgccatgc  cctttcggt  ccgctcctg  ttggcctcc  cggcctggc  60
gccgcagac  ctgccatct  tttcaaaga  cagttcttg  acggagatg  ctggaccaa  120
cgctgggtc  aatccaaac  taagtctga  tttggcaaa  tcgtcctca  ttctggcaa  180
ttctacggg  accaggaga  ggataaagg  ttgcagaca  gccaagatg  ccgatttta  240
gcgctgtcc  ccagattcg  acccttcag  aacaagggc  agacactgg  ggtacagtt  300
accgtgaag  atgagcaga  tatcgactg  gggggcggc  acgtgaagc  gtttccggg  360
ggcttggac  agaaggaca  gcatggaga  tcagaatat  acatcatgt  tggtccgga  420
atctgcggt  ctggcacca  gaaggttca  gtcatcttt  actacaagg  caagaacgt  480
ctgatcaac  aggatatcc  gtgtaagga  gatgaattc  cacatctat  cacgctgat  540
gtgcggcca  acaacacct  cgaggtgaa  attgacaac  gccaggtgg  gtcgggctc  600
ttggaggat  attgggact  tctgccgcc  aagaagatt  aggatcctg  cgctgccaa  660
ccagaagac  gggatgaac  agccaagat  gatgacccc  cagattcca  gcctgagga  720
tgggacaag  cagagcaca  ccctgaccc  gatgctaag  agcctgagg  ctgggacga  780
gagatggat  gagagtggg  accaccagt  attcaaaat  ctgaataca  gggcgaatg  840
aagccacgt  aaattgaca  cccagatta  aagggtacc  ggatacacc  agagattga  900
aatcctgaa  actcccccg  tgcgaatat  tatgcctat  atagttttg  tgtactggg  960
ttagacctc  ggcaggtca  gtctggcac  atttttgac  acttcctca  caccaatga  1020
gaggcctat  cagaggagt  tggcaatga  acctggggt  tcaccaagg  tgcagagaa  1080
cagatgaag  acaagcagg  tgaggagca  aggcttaag  aagaagaag  agacaagaa  1140
cgtaaagag  aagaggagg  cgaggataa  gaggatgag  atgacagag  tgaagatga  1200
gatgaagag  atgagaagg  agaagatga  gaggatgcc  ctggccaag  caaggatga  1260
ctgtagagg  cacaccacc  gcctccagg  ctggactga  gcctgaaca  cccgccaca  1320
agctggctg  tcccaataa  gtctctatg  gactcaaga  cttttcatt  ttttttcag  1380
caggttcag  tctggggtg  attctgatt  ttgttcccc  gcctcccca  cctccccac  1440
ccccttttt  tttactggt  tttgtcttt  attcttcag  cctcacctc  tggcctctc  1500
tttttgaat  aacattttt  ctttctgtc  ctttctcca  ctcttggtc  ctatcctcc  1560
actctagga  caggtatgg  ggaaaagcc  aggcttgag  tttcatctg  tctcctttc  1620
gaatctcag  ggagggtag  agaaggggg  ggtatcttc  ctcccccca  cactgagga  1680
gaatggggc  cttcccctt  ctcccttgc  cccaggact  ggccatttg  ggggcagcc  1740
gttctagca  agctcacac  gagagtgta  gaactacaa  caaaatttc  attaaatta  1800
gttttgtgt  ttccca  1816



<210> 2158
<211> 416
<212> PRT
<213> Rattus norvegicus
<308> P18418
<400> 2158

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Ala 
  1               5                  10                  15
Ala Asp Pro Ala Ile Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Ala 
             20                  25                  30
Trp Thr Asn Arg Trp Val Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
         35                  40                  45
Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Gln Glu Lys Asp Lys 
     50                  55                  60
Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Arg 
 65                  70                  75                  80
Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                 85                  90                  95
Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
             100                105                110
Phe Pro Gly Gly Leu Asp Gln Lys Asp Met His Gly Asp Ser Glu Tyr 
         115                120                125
Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
     130                135                140
His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
 145                150                155                160
Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                 165                170                175
Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
             180                185                190
Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
         195                200                205
Lys Asp Pro Asp Ala Ala Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
     210                215                220
Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
 225                230                235                240
His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                 245                250                255
Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
             260                265                270
Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
         275                280                285
Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Ala Asn 
     290                295                300
Ile Tyr Ala Tyr Asp Ser Phe Ala Val Leu Gly Leu Asp Leu Trp Gln 
 305                310                315                320
Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                 325                330                335
Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
             340                345                350
Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
         355                360                365
Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
     370                375                380
Lys Glu Asp Glu Asp Asp Arg Asp Glu Asp Glu Asp Glu Glu Asp Glu 
 385                390                395                400
Lys Glu Glu Asp Glu Glu Asp Ala Thr Gly Gln Ala Lys Asp Glu Leu 
                 405                410                415



<210> 2159
<211> 275
<212> DNA
<213> Homo sapiens
<308> AA654394
<400> 2159

ttttaagac  caaaactta  tttaataga  attttgttt  tagttctta  actctcagt  60
tgagctgtg  tagaactgg  tgccccaca  gtggcccag  cctgggggc  agggagaaa  120
gggatgaga  gagccccat  cttcctcag  gcgggggga  ggaaaacac  acccccttc  180
cctgccctc  tctgagatg  aggaaggag  gcagatgaa  tctcaagcc  agggcttct  240
ctctacacc  ctgttccta  agttggagg  tagtg  275



<210> 2160
<211> 417
<212> PRT
<213> Homo sapiens
<308> NP_004334
<400> 2160

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
  1               5                  10                  15
Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
             20                  25                  30
Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
         35                  40                  45
Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
     50                  55                  60
Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser 
 65                  70                  75                  80
Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                 85                  90                  95
Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
             100                105                110
Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr 
         115                120                125
Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
     130                135                140
His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
 145                150                155                160
Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                 165                170                175
Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
             180                185                190
Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
         195                200                205
Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
     210                215                220
Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
 225                230                235                240
His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                 245                250                255
Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
             260                265                270
Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
         275                280                285
Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser 
     290                295                300
Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp Gln 
 305                310                315                320
Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                 325                330                335
Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
             340                345                350
Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
         355                360                365
Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
     370                375                380
Lys Glu Asp Asp Glu Asp Lys Asp Glu Asp Glu Glu Asp Glu Glu Asp 
 385                390                395                400
Lys Glu Glu Asp Glu Glu Glu Asp Val Pro Gly Gln Ala Lys Asp Glu 
                 405                410                415
Leu 
             420



<210> 2161
<211> 1816
<212> DNA
<213> Rattus norvegicus
<308> D78308
<400> 2161

ccccctcgg  ccgccatgc  cctttcggt  ccgctcctg  ttggcctcc  cggcctggc  60
gccgcagac  ctgccatct  tttcaaaga  cagttcttg  acggagatg  ctggaccaa  120
cgctgggtc  aatccaaac  taagtctga  tttggcaaa  tcgtcctca  ttctggcaa  180
ttctacggg  accaggaga  ggataaagg  ttgcagaca  gccaagatg  ccgatttta  240
gcgctgtcc  ccagattcg  acccttcag  aacaagggc  agacactgg  ggtacagtt  300
accgtgaag  atgagcaga  tatcgactg  gggggcggc  acgtgaagc  gtttccggg  360
ggcttggac  agaaggaca  gcatggaga  tcagaatat  acatcatgt  tggtccgga  420
atctgcggt  ctggcacca  gaaggttca  gtcatcttt  actacaagg  caagaacgt  480
ctgatcaac  aggatatcc  gtgtaagga  gatgaattc  cacatctat  cacgctgat  540
gtgcggcca  acaacacct  cgaggtgaa  attgacaac  gccaggtgg  gtcgggctc  600
ttggaggat  attgggact  tctgccgcc  aagaagatt  aggatcctg  cgctgccaa  660
ccagaagac  gggatgaac  agccaagat  gatgacccc  cagattcca  gcctgagga  720
tgggacaag  cagagcaca  ccctgaccc  gatgctaag  agcctgagg  ctgggacga  780
gagatggat  gagagtggg  accaccagt  attcaaaat  ctgaataca  gggcgaatg  840
aagccacgt  aaattgaca  cccagatta  aagggtacc  ggatacacc  agagattga  900
aatcctgaa  actcccccg  tgcgaatat  tatgcctat  atagttttg  tgtactggg  960
ttagacctc  ggcaggtca  gtctggcac  atttttgac  acttcctca  caccaatga  1020
gaggcctat  cagaggagt  tggcaatga  acctggggt  tcaccaagg  tgcagagaa  1080
cagatgaag  acaagcagg  tgaggagca  aggcttaag  aagaagaag  agacaagaa  1140
cgtaaagag  aagaggagg  cgaggataa  gaggatgag  atgacagag  tgaagatga  1200
gatgaagag  atgagaagg  agaagatga  gaggatgcc  ctggccaag  caaggatga  1260
ctgtagagg  cacaccacc  gcctccagg  ctggactga  gcctgaaca  cccgccaca  1320
agctggctg  tcccaataa  gtctctatg  gactcaaga  cttttcatt  ttttttcag  1380
caggttcag  tctggggtg  attctgatt  ttgttcccc  gcctcccca  cctccccac  1440
ccccttttt  tttactggt  tttgtcttt  attcttcag  cctcacctc  tggcctctc  1500
tttttgaat  aacattttt  ctttctgtc  ctttctcca  ctcttggtc  ctatcctcc  1560
actctagga  caggtatgg  ggaaaagcc  aggcttgag  tttcatctg  tctcctttc  1620
gaatctcag  ggagggtag  agaaggggg  ggtatcttc  ctcccccca  cactgagga  1680
gaatggggc  cttcccctt  ctcccttgc  cccaggact  ggccatttg  ggggcagcc  1740
gttctagca  agctcacac  gagagtgta  gaactacaa  caaaatttc  attaaatta  1800
gttttgtgt  ttccca  1816



<210> 2162
<211> 416
<212> PRT
<213> Rattus norvegicus
<308> P18418
<400> 2162

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Ala 
  1               5                  10                  15
Ala Asp Pro Ala Ile Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Ala 
             20                  25                  30
Trp Thr Asn Arg Trp Val Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
         35                  40                  45
Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Gln Glu Lys Asp Lys 
     50                  55                  60
Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Arg 
 65                  70                  75                  80
Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                 85                  90                  95
Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
             100                105                110
Phe Pro Gly Gly Leu Asp Gln Lys Asp Met His Gly Asp Ser Glu Tyr 
         115                120                125
Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
     130                135                140
His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
 145                150                155                160
Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                 165                170                175
Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
             180                185                190
Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
         195                200                205
Lys Asp Pro Asp Ala Ala Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
     210                215                220
Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
 225                230                235                240
His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                 245                250                255
Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
             260                265                270
Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
         275                280                285
Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Ala Asn 
     290                295                300
Ile Tyr Ala Tyr Asp Ser Phe Ala Val Leu Gly Leu Asp Leu Trp Gln 
 305                310                315                320
Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                 325                330                335
Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
             340                345                350
Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
         355                360                365
Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
     370                375                380
Lys Glu Asp Glu Asp Asp Arg Asp Glu Asp Glu Asp Glu Glu Asp Glu 
 385                390                395                400
Lys Glu Glu Asp Glu Glu Asp Ala Thr Gly Gln Ala Lys Asp Glu Leu 
                 405                410                415



<210> 2163
<211> 275
<212> DNA
<213> Homo sapiens
<308> AA654394
<400> 2163

ttttaagac  caaaactta  tttaataga  attttgttt  tagttctta  actctcagt  60
tgagctgtg  tagaactgg  tgccccaca  gtggcccag  cctgggggc  agggagaaa  120
gggatgaga  gagccccat  cttcctcag  gcgggggga  ggaaaacac  acccccttc  180
cctgccctc  tctgagatg  aggaaggag  gcagatgaa  tctcaagcc  agggcttct  240
ctctacacc  ctgttccta  agttggagg  tagtg  275



<210> 2164
<211> 417
<212> PRT
<213> Homo sapiens
<308> NP_004334
<400> 2164

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
  1               5                  10                  15
Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
             20                  25                  30
Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
         35                  40                  45
Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
     50                  55                  60
Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser 
 65                  70                  75                  80
Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                 85                  90                  95
Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
             100                105                110
Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr 
         115                120                125
Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
     130                135                140
His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
 145                150                155                160
Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                 165                170                175
Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
             180                185                190
Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
         195                200                205
Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
     210                215                220
Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
 225                230                235                240
His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                 245                250                255
Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
             260                265                270
Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
         275                280                285
Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser 
     290                295                300
Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp Gln 
 305                310                315                320
Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                 325                330                335
Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
             340                345                350
Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
         355                360                365
Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
     370                375                380
Lys Glu Asp Asp Glu Asp Lys Asp Glu Asp Glu Glu Asp Glu Glu Asp 
 385                390                395                400
Lys Glu Glu Asp Glu Glu Glu Asp Val Pro Gly Gln Ala Lys Asp Glu 
                 405                410                415
Leu 
             420



<210> 2165
<211> 3560
<212> DNA
<213> Rattus norvegicus
<308> D78588
<400> 2165

ggagcggag  ctgcttccc  ggcacctgg  agtgggtcg  ggggacgcg  aggcacagg  60
cgggcggac  cgccttcgc  atgagcttg  cggcggtgc  gaccgggcg  gctgagctc  120
ggccgccgg  ccggcatgg  cgtctcccg  gagcccgct  ccggccggg  ctagggccg  180
atggagccg  gggacccca  ccccgaggc  cggagcagc  actcggagt  ggcctccgc  240
tcgtccagc  gctccgagc  cgacgcgga  ccggagccg  acaaggctc  gcggcgctt  300
accaagagg  gcttcccgg  gctgcggct  tttgggcac  ggaaagcca  caccaagtc  360
ggcctccag  acctggcac  ccctcctcc  acgcctggg  ccccgtgcg  tgaatctga  420
cggcagatc  ggagtactg  ggactggag  gagtcagca  cgtatgggg  gcacatctg  480
tttgagacc  acgtgtccg  agatttctg  tatgtcggg  agcagtact  tgtagctaa  540
atgctgccg  agtcagcgc  cagaagaaa  tgtgcagcc  gtaagatcg  ggtgcatac  600
ccttgcatc  ggcagctgg  aaagatcaa  ttccgctgt  agccatcct  ccgtgaatc  660
ggctccagg  atgtccgtg  gccaacctt  gtaagacac  actgggtcc  caggcgacg  720
caggatggc  agtgtcggc  ctgtgggaa  ggcttccag  agaagttca  cttccacag  780
aaagagatc  tagctatca  ctgttcctg  tgcaaacag  cgtaccaca  caaggtgtc  840
tgcttcatg  tgcagcaga  tgaggagcc  tgttcccta  gggtgcatg  agccgtggt  900
atcccaccc  cctggatcc  acgggcccg  aggccccag  acaccctca  ggccagcaa  960
aagaaaaag  gagcatcct  caaaaggag  tccagtaag  aaggacctg  ggaaggccg  1020
tggagaccc  tcatcatca  gcccacccc  tcccccctc  tgaagcccc  gctagtgtt  1080
gtaaacccc  agagtgggg  taaccaggg  gctaagatc  tccagtctt  tctgtggta  1140
ctgaacccc  ggcaagtct  cgatctgag  cagggagga  ccagggaag  gctggaaat  1200
taccgcaaa  tccataatt  gaggattct  gcttgcggg  gtgatggca  ggttggctg  1260
attctttcc  ccctagacc  gctgcgctt  aaaccacca  ctcctgtgg  catcctgcc  1320
ctgggcact  gcaatgacc  ggcccgaac  ctcaactgg  gtgggggtt  cacagatga  1380
ccagtgtca  agatccttt  ccatgtaga  gaggggaac  tggtacagc  ggaccgttg  1440
gacctccga  cagagccca  ccctgaggc  gggcctgag  agcgagatg  cggagccac  1500
gaccggctg  ccctggatg  cttcaacaa  tacttcagt  tgggctttg  tgcccacgt  1560
accctggag  ttcatgagt  tcgagaagc  aacccagag  agttcaaca  ccgctttcg  1620
aataagatg  tctatgctg  gacagcctt  tctgacttc  tgatgggca  ctccaagga  1680
ttagccaag  acatccgag  agtgtgtga  ggaatggac  taaccccca  gattcagga  1740
ctgaaaccg  agtgcatag  ctttctgaa  atccccagg  actgtgcag  caccatgcc  1800
tggggccac  ctggggagc  ccatgactt  gagccccag  ggcacgatg  tggctacct  1860
gaggtcatc  gcttcacca  gacatcctt  gccgcattg  aggtgggtg  acacggcga  1920
cggctgacc  agtgccgag  agtgctgct  accactgcc  aggccatcc  tgtgcaggt  1980
gatggtgaa  cctgcaagc  tgcagcatc  cggattcga  ttgccctgc  caaccaggc  2040
actatggtg  agaaggcca  gcgccggag  actgcccca  tgcacagcg  tcagcagcc  2100
gttcctgag  agctgagga  ccaagtgag  agggtcagc  tgcacgact  cgaggctct  2160
cattatgac  aggagcagc  caaggaggc  tctgtgcct  tgggtactg  ggtggtccc  2220
ggagacagt  acctagagc  ctgccgagc  cacattgag  gactccagc  ggagcccga  2280
ggggctgga  ccaagtccc  catgtgcca  ccactgtcc  ccaagtggt  tttcctgga  2340
gccaccact  ccagccgct  ctacaggat  gacagggcc  aggagcacc  caactatgt  2400
acggagatt  cccaggatg  gatttatat  ctagaccca  agctgctgg  tgcatcagc  2460
cgacctgac  tccctaccc  tacctcccc  ctccctgcc  ccccctgct  ccctacacc  2520
gggtcactg  agggggatg  cgcactgcc  caaggtgaa  agctgattg  agctgccaa  2580
aggaatgac  tctgcaagc  ccaggaact  caccgagca  gaggtgacc  catgcaccg  2640
gaccatcag  gccgcacac  cctgcacca  gcagtcagc  ctggcagta  ggaagtggt  2700
cgctatctg  tcgatcatg  accaccaga  atcctcgat  ctgtggagg  gaacgggga  2760
acctgtcta  accaggcag  cgccctagg  cagcgcacc  tctgccact  cattgtgga  2820
gccggggcc  ccctcatga  gacagatca  cagggcgac  ctcccaggc  gcgagctga  2880
aaggctcaa  acacagagc  agctgcata  ctggagaac  gacaacatt  ccagatgat  2940
caacgtgag  accaggaga  agctgtgta  ttaagggga  catggatca  cgagggaca  3000
taccagagg  ctagagctc  ccttgccca  ctcactgcc  cattcctgt  agatggcta  3060
ggggggacc  tgtcacagg  aaggagccc  gtgccaccc  ctgagaagc  gttcagatc  3120
agggctgga  tctaaggag  tggactctc  cctgtccct  gtttcatgg  gaacaggaa  3180
caagctggg  tgactgggt  cctcccttc  ggcggcctc  ccctcacca  agctgatgg  3240
atggctgga  agctcagtc  gggaggcct  ctctcagca  gactttcta  agccacctg  3300
tcccttggg  tctttggaa  gttctgggt  cctagccct  ctctctgac  cacacacct  3360
gggcatccc  gaaactcaa  agcctgctg  atttgcctg  ccgctgccc  gcttggcac  3420
taccctggt  atcctcctc  tgcacccag  catttcatt  ccgactgta  ggcctgggg  3480
ggggggtgg  gctcccacg  tgacttgtt  acagctggg  gtgactcag  aaagtgaag  3540
ttttttcct  aaaaaaagcg  3560



<210> 2166
<211> 929
<212> PRT
<213> Rattus norvegicus
<308> O08560
<400> 2166

Met Glu Pro Arg Asp Pro Ser Pro Glu Ala Arg Ser Ser Asp Ser Glu 
  1               5                  10                  15
Ser Ala Ser Ala Ser Ser Ser Gly Ser Glu Arg Asp Ala Asp Pro Glu 
             20                  25                  30
Pro Asp Lys Ala Pro Arg Arg Leu Thr Lys Arg Arg Phe Pro Gly Leu 
         35                  40                  45
Arg Leu Phe Gly His Arg Lys Ala Ile Thr Lys Ser Gly Leu Gln His 
     50                  55                  60
Leu Ala Pro Pro Pro Pro Thr Pro Gly Ala Pro Cys Gly Glu Ser Glu 
 65                  70                  75                  80
Arg Gln Ile Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Ala Tyr Gly 
                 85                  90                  95
Glu His Ile Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val 
             100                105                110
Gly Glu Gln Tyr Cys Val Ala Lys Met Leu Pro Lys Ser Ala Pro Arg 
         115                120                125
Arg Lys Cys Ala Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Gly 
     130                135                140
Gln Leu Glu Lys Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser 
 145                150                155                160
Gly Ser Arg Asn Val Arg Glu Pro Thr Phe Val Arg His His Trp Val 
                 165                170                175
His Arg Arg Arg Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe 
             180                185                190
Gln Gln Lys Phe Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys 
         195                200                205
Ser Trp Cys Lys Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu 
     210                215                220
Gln Gln Ile Glu Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val 
 225                230                235                240
Ile Pro Pro Thr Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu 
                 245                250                255
Lys Ala Ser Lys Lys Lys Lys Arg Ala Ser Phe Lys Arg Arg Ser Ser 
             260                265                270
Lys Lys Gly Pro Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro 
         275                280                285
Thr Pro Ser Pro Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys 
     290                295                300
Ser Gly Gly Asn Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr 
 305                310                315                320
Leu Asn Pro Arg Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Arg Glu 
                 325                330                335
Ala Leu Glu Met Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys 
             340                345                350
Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu 
         355                360                365
Arg Leu Lys Pro Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly 
     370                375                380
Asn Asp Leu Ala Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu 
 385                390                395                400
Pro Val Ser Lys Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln 
                 405                410                415
Leu Asp Arg Trp Asp Leu Arg Ala Glu Pro Asn Pro Glu Ala Gly Pro 
             420                425                430
Glu Glu Arg Asp Asp Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe 
         435                440                445
Asn Asn Tyr Phe Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe 
     450                455                460
His Glu Ser Arg Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg 
 465                470                475                480
Asn Lys Met Phe Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly 
                 485                490                495
Ser Ser Lys Asp Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met 
             500                505                510
Asp Leu Thr Pro Lys Ile Gln Asp Leu Lys Pro Gln Cys Ile Val Phe 
         515                520                525
Leu Asn Ile Pro Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro 
     530                535                540
Gly Glu His His Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu 
 545                550                555                560
Glu Val Ile Gly Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly 
                 565                570                575
Gly His Gly Glu Arg Leu Thr Gln Cys Arg Glu Val Leu Leu Thr Thr 
             580                585                590
Ala Lys Ala Ile Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala 
         595                600                605
Ala Ser Arg Ile Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln 
     610                615                620
Lys Ala Lys Arg Arg Ser Thr Ala Pro Leu His Ser Asp Gln Gln Pro 
 625                630                635                640
Val Pro Glu Gln Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp 
                 645                650                655
Tyr Glu Ala Leu His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val 
             660                665                670
Pro Leu Gly Thr Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys 
         675                680                685
Arg Ala His Ile Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala 
     690                695                700
Lys Ser Pro Met Cys His Pro Leu Ser Ser Lys Trp Cys Phe Leu Asp 
 705                710                715                720
Ala Thr Thr Ala Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His 
                 725                730                735
Leu Asn Tyr Val Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp 
             740                745                750
Pro Glu Leu Leu Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr 
         755                760                765
Ser Pro Leu Pro Ala Ser Pro Cys Ser Pro Thr Pro Gly Ser Leu Gln 
     770                775                780
Gly Asp Ala Ala Leu Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys 
 785                790                795                800
Arg Asn Asp Phe Cys Lys Leu Gln Glu Leu His Arg Ala Gly Gly Asp 
                 805                810                815
Leu Met His Arg Asp His Gln Ser Arg Thr Leu Leu His His Ala Val 
             820                825                830
Ser Thr Gly Ser Lys Glu Val Val Arg Tyr Leu Leu Asp His Ala Pro 
         835                840                845
Pro Glu Ile Leu Asp Ala Val Glu Glu Asn Gly Glu Thr Cys Leu His 
     850                855                860
Gln Ala Ala Ala Leu Gly Gln Arg Thr Ile Cys His Tyr Ile Val Glu 
 865                870                875                880
Ala Gly Ala Ser Leu Met Lys Thr Asp Gln Gln Gly Asp Thr Pro Arg 
                 885                890                895
Gln Arg Ala Glu Lys Ala Gln Asp Thr Glu Leu Ala Ala Tyr Leu Glu 
             900                905                910
Asn Arg Gln His Tyr Gln Met Ile Gln Arg Glu Asp Gln Glu Thr Ala 
         915                920                925
Val 
     930



<210> 2167
<211> 3490
<212> DNA
<213> Homo sapiens
<308> U51477
<400> 2167

gcggcgcgg  gcgggcgtg  tgagccccg  ccgccggcc  ggcatgggc  tctcccgcg  60
gccctccgc  ggccggggc  agggccgga  ggagccgcg  gacggtagc  ccgaggccc  120
gagcagcga  tccgagtcg  cttccgcct  gtccagcgg  tccgagcgc  acgccggtc  180
cgagccgga  aaggcgccg  ggcgactca  caagcggcg  ttcccgggg  tgcggctct  240
cgggcacag  aaagccatc  ccaagtcgg  cctccagca  ctggccccc  ctccgccca  300
ccctggggc  ccgtgcagc  agtcagagc  gcagatccg  agtacagtg  actggagcg  360
gtcagcgac  tatggggag  acatctggt  cgagaccaa  gtgtccggg  acttctgct  420
cgttgggga  cagtactgt  tagccagga  gctgaagtc  gtgtctcga  gaaagtgcg  480
agcctgcaa  attgtggtg  acacgccct  catcgagca  ctggagaag  taaatttcc  540
ctgtaagcc  tccttccgt  aatcaggct  caggaatgt  cgcgagcca  cctttgtac  600
gcaccactg  gtacacaga  gacgccagg  cggcaagtg  cggcactgt  ggaagggat  660
ccagcagaa  ttcaccttc  acagcaagg  gattgtggc  atcagctgc  cgtggtgca  720
gcaggcata  cacagcaag  tgtcctgct  catgctgca  cagatcgag  agccgtgct  780
gctgggggt  cacgcagcc  tggtcatcc  gcccacctg  atcctccgc  cccggaggc  840
ccagaatac  ctgaaagca  gcaagaaga  gaagagggc  tccttcaag  ggaagtcca  900
caagaaagg  cctgaggag  gccgctgga  acccttcat  atcaggccc  ccccctccc  960
gctcatgaa  cccctgctg  tgtttgtga  ccccaagag  gggggcaac  agggtgcaa  1020
gatcatcca  tctttcctc  ggtatctca  tccccgaca  gtcttcgac  tgagccagg  1080
agggcccaa  gaggcgctg  agatgtacc  caaagtgca  aacctgcgg  tcctggcgt  1140
cgggggcga  ggcacggtg  gctggatcc  ctccaccct  gaccagcta  gcctgaagc  1200
gccaccccc  gttgccatc  tgcccctgg  tactggcaa  gacttggcc  gaaccctca  1260
ctggggtgg  ggctacaca  atgagcctg  gtccaagat  ctctcccac  tggaggagg  1320
gaacgtggt  cagctggac  gctgggacc  ccacgctga  cccaacccc  aggcagggc  1380
tgaggaccg  gatgaaggc  ccaccgacc  gttgcccct  gatgtcttc  acaactact  1440
cagcctggg  tttgacgcc  acgtcaccc  ggagttcca  gagtctcga  aggccaacc  1500
agagaaatt  aacagccgc  ttcggaata  gatgttcta  gccgggaca  ctttctctg  1560
cttcctgat  ggcagctcc  aggacctgg  caagcacat  cgagtggtg  gtgatggaa  1620
ggacttgac  cccaagatc  aggacctga  accccagtg  gttgttttc  tgaacatcc  1680
caggtactg  gcgggcacc  tgccctggg  ccaccctgg  gagcaccac  actttgagc  1740
ccagcggca  gacgacggc  acctcgagg  cattggctt  accatgacg  cgttggccg  1800
gctgcaggt  ggcggacac  gcgagcggc  gacgcagtg  cgcgaggtg  tgctcacca  1860
atccaaggc  atcccggtg  aggtggatg  cgagccctg  aagcttgca  cctcacgca  1920
ccgcatcgc  ctgcgcaac  aggccacca  ggtgcagaa  gccaagcgg  ggagcgccg  1980
ccccctgca  agcgaccag  agccggtgc  agagcagtt  cgcatccag  tgagtcgcg  2040
cagcatgca  gactatgag  ccctgcact  cgacaagga  cagctcaag  aggcctctg  2100
gccgctggg  actgtggtg  tcccaggag  cagtgacct  gagctctgc  gtgcccaca  2160
tgagagact  cagcaggag  ccgatggtg  tggagccaa  tccccgaca  gccagaaac  2220
gtcccccaa  tggtgcttc  tggacgcca  cactgccag  cgcttctac  ggatcgacc  2280
agcccagga  cacctcaac  atgtgactg  gatcgcaca  gatgagatt  atatcctgg  2340
ccctgagct  ctgggggca  cggcccggc  tgacctccc  acccccact  cccctctcc  2400
cacctcacc  tgctcaccc  cgccccggt  actgcaagg  gatgctgca  cccctcaag  2460
tgaagagct  attgaggct  ccaagagga  cgacttctg  aagctccag  agctgcacc  2520
agctggggg  gacctcatg  accgagacg  gcagagtcg  acgctcctg  accacgcag  2580
cagcactgg  agcaaggat  tggtccgct  cctgctgga  cacgccccc  cagagatcc  2640
tgatgcggt  gaggaaaac  gggagacct  tttgcacca  gcagcggcc  tgggccagc  2700
caccatctg  cactacatc  tggaggccg  ggcctcgct  atgaagaca  accagcagg  2760
cgacactcc  cggcagcgg  ctgagaagg  tcaggacac  gagctggcc  cctacctgg  2820
gaaccggca  cactaccag  tgatccagc  ggaggacca  gagacggct  tgtagcggg  2880
cgcccacgg  cagcaggag  gacaatgcg  ccaggggac  agcgccttc  ttgcccacc  2940
cactgccac  ttccagtgg  acggccacg  ggggaccta  gccccaggg  aagagcccc  3000
tgccgcccc  taaggagcc  cccagacct  gggctggac  caggagctg  gggggcctc  3060
cctgttccc  tgaggaccc  gccggaccc  gaggctcac  gggaacaag  cacggctgg  3120
ttggatatg  ctttgccgg  gttctgggg  agggcgctc  ctggccgca  cagatgccc  3180
cccaggagt  gaggggctg  agaggggga  gccttcggg  agaggcttc  tgggccccc  3240
ggtcttcgg  cgggtcccc  gcccccgct  ctgccccac  ccacctcct  cgggcttcc  3300
cccggaaac  cagcgcctg  tgcacttgc  tgccctgcc  tgcttggca  ccgctccgg  3360
gaccctccc  gctcccctg  catttcatc  cggactgtg  ggcctgggg  tggggggcg  3420
gactctcac  gtgacatgt  tacagctgg  tgtgactca  taaagtgga  ttttttttc  3480
ttaaaaaaaa  3490



<210> 2168
<211> 1117
<212> PRT
<213> Homo sapiens
<308> Q13574
<400> 2168

Met Glu Thr Phe Phe Arg Arg His Phe Arg Gly Lys Val Pro Gly Pro 
  1               5                  10                  15
Gly Glu Gly Gln Arg Arg Pro Ser Ser Val Gly Leu Pro Thr Gly Lys 
             20                  25                  30
Ala Arg Arg Arg Ser Pro Ala Gly Gln Ala Ser Ser Ser Leu Ala Gln 
         35                  40                  45
Arg Arg Arg Ser Ser Ala Gln Leu Gln Gly Cys Leu Leu Ser Cys Gly 
     50                  55                  60
Val Arg Ala Gln Gly Ser Ser Arg Arg Arg Ser Ser Thr Val Pro Pro 
 65                  70                  75                  80
Ser Cys Asn Pro Arg Phe Ile Val Asp Lys Val Leu Thr Pro Gln Pro 
                 85                  90                  95
Thr Thr Val Gly Ala Gln Leu Leu Gly Ala Pro Leu Leu Leu Thr Gly 
             100                105                110
Leu Val Gly Met Asn Glu Glu Glu Gly Val Gln Glu Asp Val Val Ala 
         115                120                125
Glu Ala Ser Ser Ala Ile Gln Pro Gly Thr Lys Thr Pro Gly Pro Pro 
     130                135                140
Pro Pro Arg Gly Ala Gln Pro Leu Leu Pro Leu Pro Arg Tyr Val Arg 
 145                150                155                160
Arg Ala Ser Ser His Cys Cys Pro Ala Asp Ala Val Tyr Asp His Ala 
                 165                170                175
Leu Trp Gly Leu His Gly Tyr Tyr Arg Arg Leu Ser Gln Arg Arg Pro 
             180                185                190
Ser Gly Gln His Pro Gly Pro Gly Gly Arg Arg Ala Ser Gly Thr Thr 
         195                200                205
Ala Gly Thr Met Leu Pro Thr Arg Val Arg Pro Leu Ser Arg Arg Arg 
     210                215                220
Gln Val Ala Leu Arg Arg Lys Ala Ala Gly Pro Gln Ala Trp Ser Ala 
 225                230                235                240
Leu Leu Ala Lys Ala Ile Thr Lys Ser Gly Leu Gln His Leu Ala Pro 
                 245                250                255
Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu Arg Gln Ile 
             260                265                270
Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly Glu His Ile 
         275                280                285
Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val Gly Glu Gln 
     290                295                300
Tyr Cys Val Ala Arg Met Leu Lys Ser Val Ser Arg Arg Lys Cys Ala 
 305                310                315                320
Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu Gln Leu Glu Lys 
                 325                330                335
Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser Gly Ser Arg Asn 
             340                345                350
Val Arg Glu Pro Thr Phe Val Arg His His Trp Val His Arg Arg Arg 
         355                360                365
Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe Gln Gln Lys Phe 
     370                375                380
Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser Trp Cys Lys 
 385                390                395                400
Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu Gln Gln Ile Glu 
                 405                410                415
Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val Ile Pro Pro Thr 
             420                425                430
Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu Lys Ala Ser Lys 
         435                440                445
Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser Lys Lys Gly Pro 
     450                455                460
Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro Thr Pro Ser Pro 
 465                470                475                480
Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys Ser Gly Gly Asn 
                 485                490                495
Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr Leu Asn Pro Arg 
             500                505                510
Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu Ala Leu Glu Met 
         515                520                525
Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys Gly Gly Asp Gly 
     530                535                540
Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu Arg Leu Lys Pro 
 545                550                555                560
Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala 
                 565                570                575
Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu Pro Val Ser Lys 
             580                585                590
Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln Leu Asp Arg Trp 
         595                600                605
Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro Glu Asp Arg Asp 
     610                615                620
Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe Asn Asn Tyr Phe 
 625                630                635                640
Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His Glu Ser Arg 
                 645                650                655
Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn Lys Met Phe 
             660                665                670
Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly Ser Ser Lys Asp 
         675                680                685
Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met Asp Leu Thr Pro 
     690                695                700
Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe Leu Asn Ile Pro 
 705                710                715                720
Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro Gly Glu His His 
                 725                730                735
Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu Glu Val Ile Gly 
             740                745                750
Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly Gly His Gly Glu 
         755                760                765
Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr Ser Lys Ala Ile 
     770                775                780
Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala Ala Ser Arg Ile 
 785                790                795                800
Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln Lys Ala Lys Arg 
                 805                810                815
Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro Val Pro Glu Gln 
             820                825                830
Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp Tyr Glu Ala Leu 
         835                840                845
His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val Pro Leu Gly Thr 
     850                855                860
Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys Arg Ala His Ile 
 865                870                875                880
Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala Lys Ser Pro Thr 
                 885                890                895
Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp Ala Thr Thr Ala 
             900                905                910
Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His Leu Asn Tyr Val 
         915                920                925
Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp Pro Glu Leu Leu 
     930                935                940
Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr Ser Pro Leu Pro 
 945                950                955                960
Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln Gly Asp Ala Ala 
                 965                970                975
Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys Arg Asn Asp Phe 
             980                985                990
Cys Lys Leu Gln Glu Leu His Arg Ala Gly Gly Asp Leu Met His Arg 
         995                1000                1005
Asp Glu Gln Ser Arg Thr Leu Leu His His Ala Val Ser Thr Gly Ser 
     1010                1015                1020
Lys Asp Val Val Arg Tyr Leu Leu Asp His Ala Pro Pro Glu Ile Leu 
 1025                1030                1035                1040
Asp Ala Val Glu Glu Asn Gly Glu Thr Cys Leu His Gln Ala Ala Ala 
                 1045                1050                1055
Leu Gly Gln Arg Thr Ile Cys His Tyr Ile Val Glu Ala Gly Ala Ser 
             1060                1065                1070
Leu Met Lys Thr Asp Gln Gln Gly Asp Thr Pro Arg Gln Arg Ala Glu 
         1075                1080                1085
Lys Ala Gln Asp Thr Glu Leu Ala Ala Tyr Leu Glu Asn Arg Gln His 
     1090                1095                1100
Tyr Gln Met Ile Gln Arg Glu Asp Gln Glu Thr Ala Val 
 1105                1110                1115



<210> 2169
<211> 3560
<212> DNA
<213> Rattus norvegicus
<308> D78588
<400> 2169

ggagcggag  ctgcttccc  ggcacctgg  agtgggtcg  ggggacgcg  aggcacagg  60
cgggcggac  cgccttcgc  atgagcttg  cggcggtgc  gaccgggcg  gctgagctc  120
ggccgccgg  ccggcatgg  cgtctcccg  gagcccgct  ccggccggg  ctagggccg  180
atggagccg  gggacccca  ccccgaggc  cggagcagc  actcggagt  ggcctccgc  240
tcgtccagc  gctccgagc  cgacgcgga  ccggagccg  acaaggctc  gcggcgctt  300
accaagagg  gcttcccgg  gctgcggct  tttgggcac  ggaaagcca  caccaagtc  360
ggcctccag  acctggcac  ccctcctcc  acgcctggg  ccccgtgcg  tgaatctga  420
cggcagatc  ggagtactg  ggactggag  gagtcagca  cgtatgggg  gcacatctg  480
tttgagacc  acgtgtccg  agatttctg  tatgtcggg  agcagtact  tgtagctaa  540
atgctgccg  agtcagcgc  cagaagaaa  tgtgcagcc  gtaagatcg  ggtgcatac  600
ccttgcatc  ggcagctgg  aaagatcaa  ttccgctgt  agccatcct  ccgtgaatc  660
ggctccagg  atgtccgtg  gccaacctt  gtaagacac  actgggtcc  caggcgacg  720
caggatggc  agtgtcggc  ctgtgggaa  ggcttccag  agaagttca  cttccacag  780
aaagagatc  tagctatca  ctgttcctg  tgcaaacag  cgtaccaca  caaggtgtc  840
tgcttcatg  tgcagcaga  tgaggagcc  tgttcccta  gggtgcatg  agccgtggt  900
atcccaccc  cctggatcc  acgggcccg  aggccccag  acaccctca  ggccagcaa  960
aagaaaaag  gagcatcct  caaaaggag  tccagtaag  aaggacctg  ggaaggccg  1020
tggagaccc  tcatcatca  gcccacccc  tcccccctc  tgaagcccc  gctagtgtt  1080
gtaaacccc  agagtgggg  taaccaggg  gctaagatc  tccagtctt  tctgtggta  1140
ctgaacccc  ggcaagtct  cgatctgag  cagggagga  ccagggaag  gctggaaat  1200
taccgcaaa  tccataatt  gaggattct  gcttgcggg  gtgatggca  ggttggctg  1260
attctttcc  ccctagacc  gctgcgctt  aaaccacca  ctcctgtgg  catcctgcc  1320
ctgggcact  gcaatgacc  ggcccgaac  ctcaactgg  gtgggggtt  cacagatga  1380
ccagtgtca  agatccttt  ccatgtaga  gaggggaac  tggtacagc  ggaccgttg  1440
gacctccga  cagagccca  ccctgaggc  gggcctgag  agcgagatg  cggagccac  1500
gaccggctg  ccctggatg  cttcaacaa  tacttcagt  tgggctttg  tgcccacgt  1560
accctggag  ttcatgagt  tcgagaagc  aacccagag  agttcaaca  ccgctttcg  1620
aataagatg  tctatgctg  gacagcctt  tctgacttc  tgatgggca  ctccaagga  1680
ttagccaag  acatccgag  agtgtgtga  ggaatggac  taaccccca  gattcagga  1740
ctgaaaccg  agtgcatag  ctttctgaa  atccccagg  actgtgcag  caccatgcc  1800
tggggccac  ctggggagc  ccatgactt  gagccccag  ggcacgatg  tggctacct  1860
gaggtcatc  gcttcacca  gacatcctt  gccgcattg  aggtgggtg  acacggcga  1920
cggctgacc  agtgccgag  agtgctgct  accactgcc  aggccatcc  tgtgcaggt  1980
gatggtgaa  cctgcaagc  tgcagcatc  cggattcga  ttgccctgc  caaccaggc  2040
actatggtg  agaaggcca  gcgccggag  actgcccca  tgcacagcg  tcagcagcc  2100
gttcctgag  agctgagga  ccaagtgag  agggtcagc  tgcacgact  cgaggctct  2160
cattatgac  aggagcagc  caaggaggc  tctgtgcct  tgggtactg  ggtggtccc  2220
ggagacagt  acctagagc  ctgccgagc  cacattgag  gactccagc  ggagcccga  2280
ggggctgga  ccaagtccc  catgtgcca  ccactgtcc  ccaagtggt  tttcctgga  2340
gccaccact  ccagccgct  ctacaggat  gacagggcc  aggagcacc  caactatgt  2400
acggagatt  cccaggatg  gatttatat  ctagaccca  agctgctgg  tgcatcagc  2460
cgacctgac  tccctaccc  tacctcccc  ctccctgcc  ccccctgct  ccctacacc  2520
gggtcactg  agggggatg  cgcactgcc  caaggtgaa  agctgattg  agctgccaa  2580
aggaatgac  tctgcaagc  ccaggaact  caccgagca  gaggtgacc  catgcaccg  2640
gaccatcag  gccgcacac  cctgcacca  gcagtcagc  ctggcagta  ggaagtggt  2700
cgctatctg  tcgatcatg  accaccaga  atcctcgat  ctgtggagg  gaacgggga  2760
acctgtcta  accaggcag  cgccctagg  cagcgcacc  tctgccact  cattgtgga  2820
gccggggcc  ccctcatga  gacagatca  cagggcgac  ctcccaggc  gcgagctga  2880
aaggctcaa  acacagagc  agctgcata  ctggagaac  gacaacatt  ccagatgat  2940
caacgtgag  accaggaga  agctgtgta  ttaagggga  catggatca  cgagggaca  3000
taccagagg  ctagagctc  ccttgccca  ctcactgcc  cattcctgt  agatggcta  3060
ggggggacc  tgtcacagg  aaggagccc  gtgccaccc  ctgagaagc  gttcagatc  3120
agggctgga  tctaaggag  tggactctc  cctgtccct  gtttcatgg  gaacaggaa  3180
caagctggg  tgactgggt  cctcccttc  ggcggcctc  ccctcacca  agctgatgg  3240
atggctgga  agctcagtc  gggaggcct  ctctcagca  gactttcta  agccacctg  3300
tcccttggg  tctttggaa  gttctgggt  cctagccct  ctctctgac  cacacacct  3360
gggcatccc  gaaactcaa  agcctgctg  atttgcctg  ccgctgccc  gcttggcac  3420
taccctggt  atcctcctc  tgcacccag  catttcatt  ccgactgta  ggcctgggg  3480
ggggggtgg  gctcccacg  tgacttgtt  acagctggg  gtgactcag  aaagtgaag  3540
ttttttcct  aaaaaaagcg  3560



<210> 2170
<211> 929
<212> PRT
<213> Rattus norvegicus
<308> O08560
<400> 2170

Met Glu Pro Arg Asp Pro Ser Pro Glu Ala Arg Ser Ser Asp Ser Glu 
  1               5                  10                  15
Ser Ala Ser Ala Ser Ser Ser Gly Ser Glu Arg Asp Ala Asp Pro Glu 
             20                  25                  30
Pro Asp Lys Ala Pro Arg Arg Leu Thr Lys Arg Arg Phe Pro Gly Leu 
         35                  40                  45
Arg Leu Phe Gly His Arg Lys Ala Ile Thr Lys Ser Gly Leu Gln His 
     50                  55                  60
Leu Ala Pro Pro Pro Pro Thr Pro Gly Ala Pro Cys Gly Glu Ser Glu 
 65                  70                  75                  80
Arg Gln Ile Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Ala Tyr Gly 
                 85                  90                  95
Glu His Ile Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val 
             100                105                110
Gly Glu Gln Tyr Cys Val Ala Lys Met Leu Pro Lys Ser Ala Pro Arg 
         115                120                125
Arg Lys Cys Ala Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Gly 
     130                135                140
Gln Leu Glu Lys Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser 
 145                150                155                160
Gly Ser Arg Asn Val Arg Glu Pro Thr Phe Val Arg His His Trp Val 
                 165                170                175
His Arg Arg Arg Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe 
             180                185                190
Gln Gln Lys Phe Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys 
         195                200                205
Ser Trp Cys Lys Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu 
     210                215                220
Gln Gln Ile Glu Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val 
 225                230                235                240
Ile Pro Pro Thr Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu 
                 245                250                255
Lys Ala Ser Lys Lys Lys Lys Arg Ala Ser Phe Lys Arg Arg Ser Ser 
             260                265                270
Lys Lys Gly Pro Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro 
         275                280                285
Thr Pro Ser Pro Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys 
     290                295                300
Ser Gly Gly Asn Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr 
 305                310                315                320
Leu Asn Pro Arg Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Arg Glu 
                 325                330                335
Ala Leu Glu Met Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys 
             340                345                350
Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu 
         355                360                365
Arg Leu Lys Pro Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly 
     370                375                380
Asn Asp Leu Ala Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu 
 385                390                395                400
Pro Val Ser Lys Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln 
                 405                410                415
Leu Asp Arg Trp Asp Leu Arg Ala Glu Pro Asn Pro Glu Ala Gly Pro 
             420                425                430
Glu Glu Arg Asp Asp Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe 
         435                440                445
Asn Asn Tyr Phe Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe 
     450                455                460
His Glu Ser Arg Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg 
 465                470                475                480
Asn Lys Met Phe Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly 
                 485                490                495
Ser Ser Lys Asp Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met 
             500                505                510
Asp Leu Thr Pro Lys Ile Gln Asp Leu Lys Pro Gln Cys Ile Val Phe 
         515                520                525
Leu Asn Ile Pro Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro 
     530                535                540
Gly Glu His His Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu 
 545                550                555                560
Glu Val Ile Gly Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly 
                 565                570                575
Gly His Gly Glu Arg Leu Thr Gln Cys Arg Glu Val Leu Leu Thr Thr 
             580                585                590
Ala Lys Ala Ile Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala 
         595                600                605
Ala Ser Arg Ile Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln 
     610                615                620
Lys Ala Lys Arg Arg Ser Thr Ala Pro Leu His Ser Asp Gln Gln Pro 
 625                630                635                640
Val Pro Glu Gln Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp 
                 645                650                655
Tyr Glu Ala Leu His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val 
             660                665                670
Pro Leu Gly Thr Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys 
         675                680                685
Arg Ala His Ile Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala 
     690                695                700
Lys Ser Pro Met Cys His Pro Leu Ser Ser Lys Trp Cys Phe Leu Asp 
 705                710                715                720
Ala Thr Thr Ala Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His 
                 725                730                735
Leu Asn Tyr Val Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp 
             740                745                750
Pro Glu Leu Leu Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr 
         755                760                765
Ser Pro Leu Pro Ala Ser Pro Cys Ser Pro Thr Pro Gly Ser Leu Gln 
     770                775                780
Gly Asp Ala Ala Leu Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys 
 785                790                795                800
Arg Asn Asp Phe Cys Lys Leu Gln Glu Leu His Arg Ala Gly Gly Asp 
                 805                810                815
Leu Met His Arg Asp His Gln Ser Arg Thr Leu Leu His His Ala Val 
             820                825                830
Ser Thr Gly Ser Lys Glu Val Val Arg Tyr Leu Leu Asp His Ala Pro 
         835                840                845
Pro Glu Ile Leu Asp Ala Val Glu Glu Asn Gly Glu Thr Cys Leu His 
     850                855                860
Gln Ala Ala Ala Leu Gly Gln Arg Thr Ile Cys His Tyr Ile Val Glu 
 865                870                875                880
Ala Gly Ala Ser Leu Met Lys Thr Asp Gln Gln Gly Asp Thr Pro Arg 
                 885                890                895
Gln Arg Ala Glu Lys Ala Gln Asp Thr Glu Leu Ala Ala Tyr Leu Glu 
             900                905                910
Asn Arg Gln His Tyr Gln Met Ile Gln Arg Glu Asp Gln Glu Thr Ala 
         915                920                925
Val 
     930



<210> 2171
<211> 3490
<212> DNA
<213> Homo sapiens
<308> U51477
<400> 2171

gcggcgcgg  gcgggcgtg  tgagccccg  ccgccggcc  ggcatgggc  tctcccgcg  60
gccctccgc  ggccggggc  agggccgga  ggagccgcg  gacggtagc  ccgaggccc  120
gagcagcga  tccgagtcg  cttccgcct  gtccagcgg  tccgagcgc  acgccggtc  180
cgagccgga  aaggcgccg  ggcgactca  caagcggcg  ttcccgggg  tgcggctct  240
cgggcacag  aaagccatc  ccaagtcgg  cctccagca  ctggccccc  ctccgccca  300
ccctggggc  ccgtgcagc  agtcagagc  gcagatccg  agtacagtg  actggagcg  360
gtcagcgac  tatggggag  acatctggt  cgagaccaa  gtgtccggg  acttctgct  420
cgttgggga  cagtactgt  tagccagga  gctgaagtc  gtgtctcga  gaaagtgcg  480
agcctgcaa  attgtggtg  acacgccct  catcgagca  ctggagaag  taaatttcc  540
ctgtaagcc  tccttccgt  aatcaggct  caggaatgt  cgcgagcca  cctttgtac  600
gcaccactg  gtacacaga  gacgccagg  cggcaagtg  cggcactgt  ggaagggat  660
ccagcagaa  ttcaccttc  acagcaagg  gattgtggc  atcagctgc  cgtggtgca  720
gcaggcata  cacagcaag  tgtcctgct  catgctgca  cagatcgag  agccgtgct  780
gctgggggt  cacgcagcc  tggtcatcc  gcccacctg  atcctccgc  cccggaggc  840
ccagaatac  ctgaaagca  gcaagaaga  gaagagggc  tccttcaag  ggaagtcca  900
caagaaagg  cctgaggag  gccgctgga  acccttcat  atcaggccc  ccccctccc  960
gctcatgaa  cccctgctg  tgtttgtga  ccccaagag  gggggcaac  agggtgcaa  1020
gatcatcca  tctttcctc  ggtatctca  tccccgaca  gtcttcgac  tgagccagg  1080
agggcccaa  gaggcgctg  agatgtacc  caaagtgca  aacctgcgg  tcctggcgt  1140
cgggggcga  ggcacggtg  gctggatcc  ctccaccct  gaccagcta  gcctgaagc  1200
gccaccccc  gttgccatc  tgcccctgg  tactggcaa  gacttggcc  gaaccctca  1260
ctggggtgg  ggctacaca  atgagcctg  gtccaagat  ctctcccac  tggaggagg  1320
gaacgtggt  cagctggac  gctgggacc  ccacgctga  cccaacccc  aggcagggc  1380
tgaggaccg  gatgaaggc  ccaccgacc  gttgcccct  gatgtcttc  acaactact  1440
cagcctggg  tttgacgcc  acgtcaccc  ggagttcca  gagtctcga  aggccaacc  1500
agagaaatt  aacagccgc  ttcggaata  gatgttcta  gccgggaca  ctttctctg  1560
cttcctgat  ggcagctcc  aggacctgg  caagcacat  cgagtggtg  gtgatggaa  1620
ggacttgac  cccaagatc  aggacctga  accccagtg  gttgttttc  tgaacatcc  1680
caggtactg  gcgggcacc  tgccctggg  ccaccctgg  gagcaccac  actttgagc  1740
ccagcggca  gacgacggc  acctcgagg  cattggctt  accatgacg  cgttggccg  1800
gctgcaggt  ggcggacac  gcgagcggc  gacgcagtg  cgcgaggtg  tgctcacca  1860
atccaaggc  atcccggtg  aggtggatg  cgagccctg  aagcttgca  cctcacgca  1920
ccgcatcgc  ctgcgcaac  aggccacca  ggtgcagaa  gccaagcgg  ggagcgccg  1980
ccccctgca  agcgaccag  agccggtgc  agagcagtt  cgcatccag  tgagtcgcg  2040
cagcatgca  gactatgag  ccctgcact  cgacaagga  cagctcaag  aggcctctg  2100
gccgctggg  actgtggtg  tcccaggag  cagtgacct  gagctctgc  gtgcccaca  2160
tgagagact  cagcaggag  ccgatggtg  tggagccaa  tccccgaca  gccagaaac  2220
gtcccccaa  tggtgcttc  tggacgcca  cactgccag  cgcttctac  ggatcgacc  2280
agcccagga  cacctcaac  atgtgactg  gatcgcaca  gatgagatt  atatcctgg  2340
ccctgagct  ctgggggca  cggcccggc  tgacctccc  acccccact  cccctctcc  2400
cacctcacc  tgctcaccc  cgccccggt  actgcaagg  gatgctgca  cccctcaag  2460
tgaagagct  attgaggct  ccaagagga  cgacttctg  aagctccag  agctgcacc  2520
agctggggg  gacctcatg  accgagacg  gcagagtcg  acgctcctg  accacgcag  2580
cagcactgg  agcaaggat  tggtccgct  cctgctgga  cacgccccc  cagagatcc  2640
tgatgcggt  gaggaaaac  gggagacct  tttgcacca  gcagcggcc  tgggccagc  2700
caccatctg  cactacatc  tggaggccg  ggcctcgct  atgaagaca  accagcagg  2760
cgacactcc  cggcagcgg  ctgagaagg  tcaggacac  gagctggcc  cctacctgg  2820
gaaccggca  cactaccag  tgatccagc  ggaggacca  gagacggct  tgtagcggg  2880
cgcccacgg  cagcaggag  gacaatgcg  ccaggggac  agcgccttc  ttgcccacc  2940
cactgccac  ttccagtgg  acggccacg  ggggaccta  gccccaggg  aagagcccc  3000
tgccgcccc  taaggagcc  cccagacct  gggctggac  caggagctg  gggggcctc  3060
cctgttccc  tgaggaccc  gccggaccc  gaggctcac  gggaacaag  cacggctgg  3120
ttggatatg  ctttgccgg  gttctgggg  agggcgctc  ctggccgca  cagatgccc  3180
cccaggagt  gaggggctg  agaggggga  gccttcggg  agaggcttc  tgggccccc  3240
ggtcttcgg  cgggtcccc  gcccccgct  ctgccccac  ccacctcct  cgggcttcc  3300
cccggaaac  cagcgcctg  tgcacttgc  tgccctgcc  tgcttggca  ccgctccgg  3360
gaccctccc  gctcccctg  catttcatc  cggactgtg  ggcctgggg  tggggggcg  3420
gactctcac  gtgacatgt  tacagctgg  tgtgactca  taaagtgga  ttttttttc  3480
ttaaaaaaaa  3490



<210> 2172
<211> 1117
<212> PRT
<213> Homo sapiens
<308> Q13574
<400> 2172

Met Glu Thr Phe Phe Arg Arg His Phe Arg Gly Lys Val Pro Gly Pro 
  1               5                  10                  15
Gly Glu Gly Gln Arg Arg Pro Ser Ser Val Gly Leu Pro Thr Gly Lys 
             20                  25                  30
Ala Arg Arg Arg Ser Pro Ala Gly Gln Ala Ser Ser Ser Leu Ala Gln 
         35                  40                  45
Arg Arg Arg Ser Ser Ala Gln Leu Gln Gly Cys Leu Leu Ser Cys Gly 
     50                  55                  60
Val Arg Ala Gln Gly Ser Ser Arg Arg Arg Ser Ser Thr Val Pro Pro 
 65                  70                  75                  80
Ser Cys Asn Pro Arg Phe Ile Val Asp Lys Val Leu Thr Pro Gln Pro 
                 85                  90                  95
Thr Thr Val Gly Ala Gln Leu Leu Gly Ala Pro Leu Leu Leu Thr Gly 
             100                105                110
Leu Val Gly Met Asn Glu Glu Glu Gly Val Gln Glu Asp Val Val Ala 
         115                120                125
Glu Ala Ser Ser Ala Ile Gln Pro Gly Thr Lys Thr Pro Gly Pro Pro 
     130                135                140
Pro Pro Arg Gly Ala Gln Pro Leu Leu Pro Leu Pro Arg Tyr Val Arg 
 145                150                155                160
Arg Ala Ser Ser His Cys Cys Pro Ala Asp Ala Val Tyr Asp His Ala 
                 165                170                175
Leu Trp Gly Leu His Gly Tyr Tyr Arg Arg Leu Ser Gln Arg Arg Pro 
             180                185                190
Ser Gly Gln His Pro Gly Pro Gly Gly Arg Arg Ala Ser Gly Thr Thr 
         195                200                205
Ala Gly Thr Met Leu Pro Thr Arg Val Arg Pro Leu Ser Arg Arg Arg 
     210                215                220
Gln Val Ala Leu Arg Arg Lys Ala Ala Gly Pro Gln Ala Trp Ser Ala 
 225                230                235                240
Leu Leu Ala Lys Ala Ile Thr Lys Ser Gly Leu Gln His Leu Ala Pro 
                 245                250                255
Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu Arg Gln Ile 
             260                265                270
Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly Glu His Ile 
         275                280                285
Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val Gly Glu Gln 
     290                295                300
Tyr Cys Val Ala Arg Met Leu Lys Ser Val Ser Arg Arg Lys Cys Ala 
 305                310                315                320
Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu Gln Leu Glu Lys 
                 325                330                335
Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser Gly Ser Arg Asn 
             340                345                350
Val Arg Glu Pro Thr Phe Val Arg His His Trp Val His Arg Arg Arg 
         355                360                365
Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe Gln Gln Lys Phe 
     370                375                380
Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser Trp Cys Lys 
 385                390                395                400
Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu Gln Gln Ile Glu 
                 405                410                415
Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val Ile Pro Pro Thr 
             420                425                430
Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu Lys Ala Ser Lys 
         435                440                445
Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser Lys Lys Gly Pro 
     450                455                460
Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro Thr Pro Ser Pro 
 465                470                475                480
Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys Ser Gly Gly Asn 
                 485                490                495
Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr Leu Asn Pro Arg 
             500                505                510
Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu Ala Leu Glu Met 
         515                520                525
Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys Gly Gly Asp Gly 
     530                535                540
Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu Arg Leu Lys Pro 
 545                550                555                560
Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala 
                 565                570                575
Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu Pro Val Ser Lys 
             580                585                590
Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln Leu Asp Arg Trp 
         595                600                605
Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro Glu Asp Arg Asp 
     610                615                620
Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe Asn Asn Tyr Phe 
 625                630                635                640
Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His Glu Ser Arg 
                 645                650                655
Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn Lys Met Phe 
             660                665                670
Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly Ser Ser Lys Asp 
         675                680                685
Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met Asp Leu Thr Pro 
     690                695                700
Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe Leu Asn Ile Pro 
 705                710                715                720
Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro Gly Glu His His 
                 725                730                735
Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu Glu Val Ile Gly 
             740                745                750
Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly Gly His Gly Glu 
         755                760                765
Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr Ser Lys Ala Ile 
     770                775                780
Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala Ala Ser Arg Ile 
 785                790                795                800
Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln Lys Ala Lys Arg 
                 805                810                815
Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro Val Pro Glu Gln 
             820                825                830
Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp Tyr Glu Ala Leu 
         835                840                845
His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val Pro Leu Gly Thr 
     850                855                860
Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys Arg Ala His Ile 
 865                870                875                880
Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala Lys Ser Pro Thr 
                 885                890                895
Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp Ala Thr Thr Ala 
             900                905                910
Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His Leu Asn Tyr Val 
         915                920                925
Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp Pro Glu Leu Leu 
     930                935                940
Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr Ser Pro Leu Pro 
 945                950                955                960
Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln Gly Asp Ala Ala 
                 965                970                975
Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys Arg Asn Asp Phe 
             980                985                990
Cys Lys Leu Gln Glu Leu His Arg Ala Gly Gly Asp Leu Met His Arg 
         995                1000                1005
Asp Glu Gln Ser Arg Thr Leu Leu His His Ala Val Ser Thr Gly Ser 
     1010                1015                1020
Lys Asp Val Val Arg Tyr Leu Leu Asp His Ala Pro Pro Glu Ile Leu 
 1025                1030                1035                1040
Asp Ala Val Glu Glu Asn Gly Glu Thr Cys Leu His Gln Ala Ala Ala 
                 1045                1050                1055
Leu Gly Gln Arg Thr Ile Cys His Tyr Ile Val Glu Ala Gly Ala Ser 
             1060                1065                1070
Leu Met Lys Thr Asp Gln Gln Gly Asp Thr Pro Arg Gln Arg Ala Glu 
         1075                1080                1085
Lys Ala Gln Asp Thr Glu Leu Ala Ala Tyr Leu Glu Asn Arg Gln His 
     1090                1095                1100
Tyr Gln Met Ile Gln Arg Glu Asp Gln Glu Thr Ala Val 
 1105                1110                1115



<210> 2173
<211> 892
<212> DNA
<213> Rattus norvegicus
<308> D78613
<400> 2173

atggagccc  tgtgtccac  cctgttggc  agttttagc  tgtcgcttg  cacagctgg  60
cagggcaac  acaccaccc  aacagagag  aactggacc  gtacaactg  aggccctcc  120
gaccctggc  cgtcccagc  gctgcttac  tggctgctg  tgcctctgc  cctcctcct  180
ttcctcctt  cagcctact  cttcaggtt  aggaagcag  ggaaagccg  ggtcaacag  240
aacgacaag  agatgccta  cgggatcct  gaagaacaa  agcagcaga  agtgatgct  300
ctgagcaga  ctccatcgg  tcccaagaa  tacttcccc  tccctgtgg  gcacctgga  360
gaggagatc  gggtgagat  tgcggatga  tgcaagcgg  tccgagagg  gttcaattc  420
ttgccatcc  gacacatac  aggaacctt  gaactagca  ataaagaag  aaacagaga  480
aaaaacaga  accccaaca  tctgcccaa  gatcattgc  gagtgattt  gagccaatt  540
gatggaatc  cctgctctg  ctacattaa  gcttcctac  tagatggct  caaagaaaa  600
aacaaattc  tagcagctc  aggccccaa  caggagaca  tgaatgact  ctggagaat  660
gtctgggag  aaaggtcag  caccattgt  atgttgacg  acctgaagg  aaggaagga  720
gagaagtgc  accagtact  gccagacca  ggctgttgg  cttatggga  catccgggt  780
tgtgtagag  actgcgtgg  cctggtgga  tacaccatc  gcaagttct  catccatcc  840
caactcccc  acagctgca  agctccacg  ctggtctca  agctgcact  ca  892



<210> 2174
<211> 297
<212> PRT
<213> Rattus norvegicus
<308> BAA11433
<400> 2174

Met Glu Pro Leu Cys Pro Leu Leu Leu Ala Ser Phe Ser Leu Ser Leu 
  1               5                  10                  15
Ala Thr Ala Gly Gln Gly Asn Asp Thr Thr Pro Thr Glu Ser Asn Trp 
             20                  25                  30
Thr Ser Thr Thr Ala Gly Pro Pro Asp Pro Gly Thr Ser Gln Pro Leu 
         35                  40                  45
Leu Thr Trp Leu Leu Leu Pro Leu Leu Leu Leu Leu Phe Leu Leu Ala 
     50                  55                  60
Ala Tyr Phe Phe Arg Phe Arg Lys Gln Arg Lys Ala Val Val Asn Ser 
 65                  70                  75                  80
Asn Asp Lys Lys Met Pro Asn Gly Ile Leu Glu Glu Gln Glu Gln Gln 
                 85                  90                  95
Arg Val Met Leu Leu Ser Arg Ser Pro Ser Gly Pro Lys Lys Tyr Phe 
             100                105                110
Pro Ile Pro Val Glu His Leu Glu Glu Glu Ile Arg Val Arg Ser Ala 
         115                120                125
Asp Asp Cys Lys Arg Phe Arg Glu Glu Phe Asn Ser Leu Pro Ser Gly 
     130                135                140
His Ile Gln Gly Thr Phe Glu Leu Ala Asn Lys Glu Glu Asn Arg Glu 
 145                150                155                160
Lys Asn Arg Tyr Pro Asn Ile Leu Pro Asn Asp His Cys Arg Val Ile 
                 165                170                175
Leu Ser Gln Leu Asp Gly Ile Pro Cys Ser Asp Tyr Ile Asn Ala Ser 
             180                185                190
Tyr Ile Asp Gly Tyr Lys Glu Lys Asn Lys Phe Ile Ala Ala Gln Gly 
         195                200                205
Pro Lys Gln Glu Thr Val Asn Asp Phe Trp Arg Met Val Trp Glu Gln 
     210                215                220
Arg Ser Ala Thr Ile Val Met Leu Thr Asn Leu Lys Glu Arg Lys Glu 
 225                230                235                240
Glu Lys Cys Tyr Gln Tyr Trp Pro Asp Gln Gly Cys Trp Thr Tyr Gly 
                 245                250                255
Asn Ile Arg Val Cys Val Glu Asp Cys Val Val Leu Val Asp Tyr Thr 
             260                265                270
Ile Arg Lys Phe Cys Ile His Pro Gln Leu Pro Asp Ser Cys Lys Ala 
         275                280                285
Pro Arg Leu Val Ser Gln Leu His Phe 
     290                295



<210> 2175
<211> 1952
<212> DNA
<213> Rattus norvegicus
<308> D82074
<400> 2175

gcggcacga  cgcccacgc  gaaggcaag  tgtcccgag  ctccagggt  atgagatcg  60
cactattca  aacctttta  caacaggaa  tggaaacat  accaaatca  acagcgaga  120
cgggctgat  ggcgagcct  agccccaag  tcccccaag  tggacagac  agtgcctca  180
ttctcagga  gaggaacac  aggcagaca  gaaggagga  gagcttgaa  ccatgaatg  240
agaggagga  tctctgaga  acgggggag  ggaggagga  gaagatgag  atctggaag  300
ggaggaaga  gaggaggaa  aggaggatg  tcaaaagcc  aagagacgg  gccccaaaa  360
gaaaaagat  accaaggcg  gcctagagc  ttttaaatt  agacgcatg  aggccaatg  420
ccgcgagcg  aaccgcatg  acgggctga  tgcggcgct  gacaacctg  gaaaggtgg  480
accctgcta  tctaagaca  agaagctgt  taagataga  acactgcgc  tggccaaga  540
ctatatctg  gctctgtca  agatcctgc  ctcaggcaa  agcccagac  tcgtctcct  600
tgtacagac  ctctgcaaa  gtttgtccc  gcccactac  aatttggtg  ctggctgct  660
gcagctcaa  ccccggact  tcttgcctg  gcagaatcc  gacatgccc  cacacctgc  720
aaccgccag  gcttccttc  cggtgcatc  ctactccta  cagtcccct  gactgccca  780
cccgcccta  ggcaccatg  acagctccc  tgtcttcca  gtcaagccg  cgccacacg  840
ctacagcgc  gccctggag  ccttctttg  aagccccct  actgattgc  ccagccctt  900
ctttgacgg  cccctcagc  cgccgctca  catcaatgg  aacttctct  tcaaacacg  960
accatccac  gagtttgaa  aaaattatg  ctttaccat  cactaccct  cagcgaccc  1020
ggcagggcc  caaagccac  gatcaatct  ctcctcggg  gccgctgct  ctcgctgtg  1080
gatccccat  gacaatatt  tgtctttcg  tagccattc  catcatgag  gagtcatga  1140
tgcccagct  aatgccatc  ttcacgatt  gaggcacgt  agtttcacc  ttcccggga  1200
acgaatcca  tgtgcttac  gtgactgtc  tgtttacag  aggcagccc  tttgataac  1260
ttgctgcaa  gtgcaaata  tcgaagctt  aagggatat  tgtatttat  gtcgttact  1320
cctttggaa  aaacagggg  tcaaagttc  tgttcacct  atctattgt  ttctatagc  1380
cttctattt  aaaaaataa  agtacagta  agtaaaaaa  gaaaatgtg  accacgaat  1440
tcgtgtagc  gtattcaga  cgtattaat  atctgatcg  gataaaaaa  atcaagcaa  1500
aattaggat  tatgcaatt  ttaaactag  aatgggcca  ttaaagtat  tataaatat  1560
tatttttca  ccagcattt  actacttgt  acctttccc  tgccgaatt  ttttgttgt  1620
attttgtac  gaattttta  tgacttttt  taacgtgga  ttcctattt  aaaaccatg  1680
agcttcatc  atttttata  atatcagaa  agtagaatt  tatctaatt  atacaaaaa  1740
aatttaact  atttaaacc  gcagaaaag  gcttagaaa  ttattgcgt  gccttagca  1800
ttctttctt  tctaattgt  aaaaaaaaa  aatagaaaa  aaaagagaa  aacaacaaa  1860
tgcacaatt  gagcaattc  tctcacttt  aagtctttc  ctctcccta  agtagaaac  1920
agacccata  cactcaaga  gaaaaaaaa  aa  1952



<210> 2176
<211> 357
<212> PRT
<213> Rattus norvegicus
<308> BAA11535
<400> 2176

Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 
  1               5                  10                  15
Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 
             20                  25                  30
Glu His Glu Ala Asp Lys Lys Glu Asp Glu Leu Glu Ala Met Asn Ala 
         35                  40                  45
Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Asp Glu Asp Glu 
     50                  55                  60
Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Gln Lys 
 65                  70                  75                  80
Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 
                 85                  90                  95
Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 
             100                105                110
Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 
         115                120                125
Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr Leu Arg 
     130                135                140
Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 
 145                150                155                160
Lys Ser Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 
                 165                170                175
Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 
             180                185                190
Arg Thr Phe Leu Pro Glu Gln Asn Pro Asp Met Pro Pro His Leu Pro 
         195                200                205
Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro 
     210                215                220
Gly Leu Pro Ser Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 
 225                230                235                240
His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 
                 245                250                255
Phe Glu Ser Pro Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro 
             260                265                270
Leu Ser Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 
         275                280                285
Pro Ser Thr Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 
     290                295                300
Ala Ala Thr Leu Ala Gly Pro Gln Ser His Gly Ser Ile Phe Ser Ser 
 305                310                315                320
Gly Ala Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser 
                 325                330                335
Phe Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn 
             340                345                350
Ala Ile Phe His Asp 
         355



<210> 2177
<211> 2502
<212> DNA
<213> Homo sapiens
<308> XM_002573
<400> 2177

cggccacga  acgaggaat  cgcccacgc  ggaggcgcg  cgtccggag  ccccagggt  60
atgagacta  cactgctca  gacctacta  caacaaagg  aatcgaaac  tgaccaaat  120
gtacagcga  agtgggctg  tgggcgagc  tcagcccca  ggtcctcca  gctggacag  180
cgagtgtct  agttctcag  acgaggagc  cgaggcaga  aagaaggag  acgacctcg  240
aaccatgaa  gcagaggag  actcactga  gaacggggg  gaggaggag  acgaagatg  300
ggacctgga  gaggaggaa  aagaggaag  ggaggatga  gatcaaaag  ccaagagac  360
cggccccaa  aagaagaag  tgactaagg  tcgcctgga  cgttttaaa  tgagacgca  420
gaaggctaa  gcccgggag  ggaaccgca  gcacggact  aacgcggcg  tagacaacc  480
gcgcaaggt  gtgccttgc  attctaaga  gcagaagct  tccaaaatc  agactctgc  540
cttggccaa  aactacatc  gggctctgt  ggagatcct  cgctcaggc  aaagcccag  600
cctggtctc  ttcgttcag  cgctttgca  gggcttatc  caacccacc  ccaacctgg  660
tgcgggctg  ctgcaactc  atcctcgga  ttttctgcc  gagcagaac  aggacatgc  720
cccccacct  ccgacggcc  gcgcttcct  ccctgtaca  ccctactcc  accagtcgc  780
tgggctgcc  agtccgcct  acggtacca  ggacagctc  catgtcttc  acgttaagc  840
tccgccgca  gcctacagc  cagcgctgg  gcccttctt  gaaagccct  tgactgatt  900
caccagccc  tcctttgat  gacccctca  cccgccgct  agcatcaat  gcaacttct  960
tttcaaaca  gaaccgtcc  ccgagtttg  gaaaaatta  gcctttacc  tgcactatc  1020
tgcagcgac  ctggcaggg  cccaaagcc  cggatcaat  ttctcaggc  ccgctgccc  1080
tcgctgcga  atccccata  acaatatta  gtccttcga  agccattca  atcatgagc  1140
agtcatgag  gcccagctc  atgccatat  tcatgatta  aggcacgcc  gtttcacca  1200
ttccgggaa  cgaacccac  gtgcttaca  tgactgtcg  gtttacaaa  ggcagccct  1260
tgggtacta  tgctgcaaa  tgcaaatac  ccaagcttc  agtgatata  gtatttatt  1320
tcattactg  ctttggaag  aacagggga  caaagttcc  gttcacctt  tgtattatt  1380
tctatagct  ttctattta  aaaataaaa  aatacagta  agtttaaaa  atacaccac  1440
aatttggtg  ggctgtatt  agatcgtat  aattatctg  tcgggataa  aaaatcaca  1500
gcaataatt  ggatctatg  aatttttaa  ctagtaatg  gccaattaa  atatatata  1560
atatatatt  ttcaaccag  attttacta  ttgttacct  tcccatgct  aattatttt  1620
ttgtgattt  gtacagaat  tttaatgac  ttttataat  tggatttcc  attttaaaa  1680
catgcagct  catcaattt  tatacatat  agaaaagta  aattatatc  aatttatac  1740
aaataattt  actaattta  accagcaga  aagtgctta  aaagttatt  tgttgcctt  1800
gcacttctt  cctctccaa  tgtaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaatt  1860
cacaatttg  gcaattcat  tcactttaa  gtctttccg  ctccctaaa  taaaaacca  1920
aatcataat  ttcaagaga  gaaaaaatt  agagataca  tccctatca  aacatatca  1980
ttcaacaca  tacttgcac  agcttgtat  tacatatta  aaataaatg  caacatacc  2040
ttctttaaa  caaaagctg  ttgactatc  catacaatt  gcactgtta  tttttagtc  2100
tttactcct  tgcattcca  gattttaca  agaatctga  gctattgat  tttccagaa  2160
atataaatg  atgatttta  acatagtca  aaaaatggt  gtttgtcat  tattcatgt  2220
ataaatctg  gcctaaatc  aatcaggtt  ttaatgttg  gatttatat  tatagtagt  2280
aattagtac  gtagcttaa  taaattcaa  ccatttaat  cataattag  acaatagct  2340
ttgcatgta  aatgcagtc  agaataagt  ctgtttgag  tgtgatgct  gtaccactg  2400
aatcgatct  tactgtaat  ttgtttgta  tcctgtata  tatggtgta  tgcacaatt  2460
agaaaacat  catccagtt  caataaaat  gtattgaaa  tg  2502



<210> 2178
<211> 356
<212> PRT
<213> Homo sapiens
<308> XP_002573
<400> 2178

Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 
  1               5                  10                  15
Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 
             20                  25                  30
Glu His Glu Ala Asp Lys Lys Glu Asp Asp Leu Glu Thr Met Asn Ala 
         35                  40                  45
Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Asp Glu Asp Glu 
     50                  55                  60
Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Gln Lys 
 65                  70                  75                  80
Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 
                 85                  90                  95
Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 
             100                105                110
Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 
         115                120                125
Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr Leu Arg 
     130                135                140
Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 
 145                150                155                160
Lys Ser Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 
                 165                170                175
Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 
             180                185                190
Arg Thr Phe Leu Pro Glu Gln Asn Gln Asp Met Pro Pro His Leu Pro 
         195                200                205
Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro 
     210                215                220
Gly Leu Pro Ser Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 
 225                230                235                240
His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 
                 245                250                255
Phe Glu Ser Pro Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro 
             260                265                270
Leu Ser Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 
         275                280                285
Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 
     290                295                300
Ala Ala Thr Leu Ala Gly Ala Gln Ser His Gly Ser Ile Phe Ser Gly 
 305                310                315                320
Thr Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser Phe 
                 325                330                335
Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn Ala 
             340                345                350
Ile Phe His Asp 
         355



<210> 2179
<211> 1621
<212> DNA
<213> Rattus norvegicus
<308> D82928
<400> 2179

gtggatcgc  cgggagaac  gggcccagg  ctcaggtgg  gctgccgat  ccccgggct  60
aaaggtgag  ccacgctgg  gaggctggg  caagacctt  cacctccag  cctgggccg  120
gaccacaag  ggagccgcc  agatgccag  ggaaaatat  ttcctgttc  tgcctaatc  180
tattggtta  gcccggatt  ttttcgcca  catttcctt  tactttatg  cctgctgcc  240
cttcacggc  tcctccttc  atctactca  cggacttct  gacgctttc  atggacacg  300
agctcgagc  cttaatcaa  gaacccgat  tggggccat  ctcgacatg  tgacggacc  360
ttgcgccac  atgtgtctc  tggtcaacc  ggccctgct  taccctcgg  ccactcttc  420
gttccagct  agcatgagc  tggacgtgg  cagtcactg  ctgcatctg  acagttctg  480
ggtgcgagg  agtgagagc  acaagatga  tgacctgtc  gggaaccct  tgcttcgaa  540
ctactatac  tccaggcct  ctctgttca  cctgtgtgc  ggaaatgaa  tcttctact  600
cctcctgta  ctgttcaat  tctccgagg  accactagt  ggctctgtg  ggcttttcc  660
aatgggcct  tggatcaca  ctcccattg  cctgctcaa  tccatcatt  gtgtcatcc  720
cctcgtcac  gctgcaagg  acatggctg  cctcgatgc  gcagaccgc  ccaagaaga  780
atgatcctc  cccatcccc  gctgcccac  tgccctggg  atctactgt  ccacatggc  840
cctctcctc  taagaggtc  cagtgtcat  tctttctca  gtgttctct  acctgctgg  900
attgggggt  accctctgt  tggtgttgt  actgtcttt  tactcctga  aactagacc  960
aacccgtga  cccaaggac  tggcactgc  aagcaggaa  ggtgctcag  aggcccact  1020
atccagccg  tgctccagg  ggcctgtct  aagactggg  gttgccaca  atcctgctg  1080
atcagcctg  ggtctggcc  gagactttg  gaacttata  gggcaaagg  gtcaggctg  1140
tgggccaag  aggctgggg  accaggcca  ggagggaag  ggccaaggg  caactagat  1200
tttccctta  gcaagctcc  ctatcctgt  ctgctctgg  aacctccat  ataaagggg  1260
gcaccttca  tctttttgg  tttgtttac  ttgggacac  cttagatga  ggcctaggg  1320
tcaaaggag  tgggtaaaa  aaaaagaaa  ccacctgga  gcttttccc  caaaggtgg  1380
tggctcctc  ctgtcattc  agtgacctc  gagaggcct  gaggttcac  agcgttgtc  1440
tgcccacct  ctctatgtc  tggctggcc  ctttcactg  aaccttgat  tttttgacc  1500
tcatgagaa  gtaagcttc  caagagcag  tttagatct  tctcgtctc  gcctggagt  1560
aaaagtagc  tggcatgtg  taactgctt  ataaatatt  atggaaaga  gaaaaaaat  1620
c  1621



<210> 2180
<211> 213
<212> PRT
<213> Rattus norvegicus
<308> P70500
<400> 2180

Met Pro Glu Glu Asn Ile Phe Leu Phe Val Pro Asn Leu Ile Gly Tyr 
  1               5                  10                  15
Ala Arg Ile Val Phe Ala Ile Ile Ser Phe Tyr Phe Met Pro Cys Cys 
             20                  25                  30
Pro Phe Thr Ala Ser Ser Phe Tyr Leu Leu Ser Gly Leu Leu Asp Ala 
         35                  40                  45
Phe Asp Gly His Ala Ala Arg Ala Leu Asn Gln Gly Thr Arg Phe Gly 
     50                  55                  60
Ala Met Leu Asp Met Leu Thr Asp Arg Cys Ala Thr Met Cys Leu Leu 
 65                  70                  75                  80
Val Asn Leu Ala Leu Leu Tyr Pro Arg Ala Thr Leu Leu Phe Gln Leu 
                 85                  90                  95
Ser Met Ser Leu Asp Val Ala Ser His Trp Leu His Leu His Ser Ser 
             100                105                110
Val Val Arg Gly Ser Glu Ser His Lys Met Ile Asp Leu Ser Gly Asn 
         115                120                125
Pro Val Leu Arg Ile Tyr Tyr Thr Ser Arg Pro Ala Leu Phe Thr Leu 
     130                135                140
Cys Ala Gly Asn Glu Leu Phe Tyr Cys Leu Leu Tyr Leu Phe Asn Phe 
 145                150                155                160
Ser Glu Gly Pro Leu Val Gly Ser Val Gly Leu Phe Arg Met Gly Leu 
                 165                170                175
Trp Ile Thr Ala Pro Ile Ala Leu Leu Lys Ser Ile Ile Ser Val Ile 
             180                185                190
His Leu Val Thr Ala Ala Arg Asn Met Ala Ala Leu Asp Ala Ala Asp 
         195                200                205
Arg Ala Lys Lys Lys 
     210



<210> 2181
<211> 1833
<212> DNA
<213> Homo sapiens
<308> AF014807
<400> 2181

gaattcggc  cgaggcgcg  aggaggagg  tcccggaag  cacgcgcac  gggagcagc  60
gcgaccgca  ctggaggcc  ggagcgcct  cggggctgg  agaggcgag  gaggttgcg  120
gtaggaagg  cgggactgc  cgcgccccc  gcgtcccgc  cacctcggg  ccggtccat  180
ctcccgacg  ctgcgggct  cagcatctg  ggccaggtt  gggcggcgg  gtccagggc  240
cagtggtgc  gccgatgcg  cggggccgg  gctgaaggc  gcgctgcgg  gctgggaca  300
cactggcat  tccagagca  gcccggggc  gcaagggag  cgccgcgat  ccagacgaa  360
atatcttcc  gttcgtgcc  aacctcatc  gttatgccc  gattgtctt  gccatcatt  420
ctttctact  catgccctg  tgccccctc  cggcctcct  cttctacct  ctcagcggc  480
tgctggacg  tttcgatgg  cacgctgct  gcgctctta  tcaaggaac  cggtttggg  540
ccatgctgg  catgctgac  gaccgctgc  ccaccatgt  cctgttggt  aacctggcc  600
tgctgtacc  tggagccac  ctgttcttc  aaatcagca  gagtttgga  gtggccagt  660
actggctgc  cctccacag  tctgtggtc  gaggcagtg  gagtcacaa  atgatcgac  720
tgtccggga  tccggtgct  cggatctac  acacctcga  gcctgctct  ttcaccttg  780
gtgctggga  tgagctctt  tactgcctc  tctacctgt  ccatttctc  gagggacct  840
tagttggct  tgtgggact  ttccggatg  gcctctggg  cactgcccc  atcgccttg  900
tgaagtcgc  catcagcgt  atccacctg  tcacggccg  ccgcaacat  gctgccctg  960
acgcagcag  ccgcgccaa  aagaagtga  gctggagcc  cgggtcctg  ctgcccacc  1020
gccctggga  tcttgctgt  ccacacagc  ccccacccc  tgctaggag  tcccagtct  1080
acgccttcc  catgtgttg  tctacctgc  gggatgggg  tcagcctct  tttggtgac  1140
tcacgttct  tgggatcct  aggacccgg  cctcaaatc  gggaggata  gcgggaggc  1200
ccctccatc  aggcggtgc  cctggggtg  cgggaccgg  cagtgtcac  ccctgcctg  1260
tcagtcctg  ggtccgaga  gctagggac  cttgagtga  ggaggtggt  tgagggcca  1320
gtttcctga  aggcgggag  cagacctcc  cccccagcc  gagcaagct  ggggcacca  1380
gcccaggag  gaagaagcc  tccacagcc  tccctgtca  cggctcctc  gtcctgcct  1440
accctggtc  tggcgggac  tcactattt  acttggttt  ctttcagat  ttcttggct  1500
agggcctgg  ttgagggag  ttagggaag  acgtccgtc  gggtgcttt  cctccagtt  1560
gctggctgg  ttctccgtc  acccacagt  acctcacag  gaggccctc  tgccaccca  1620
gctcatgtg  tgtccccac  gcccacttg  ttgatgtca  tgactgtct  catgtattt  1680
tattcttga  attttctac  ctcactaga  tgtaaactc  atgaaggca  agacttttc  1740
tgttctctt  tctatccct  gagtaagac  aacttgaac  tggcatata  tagctgctt  1800
ataaatact  gtctgtcaa  aaaaaaaaa  aaa  1833



<210> 2182
<211> 213
<212> PRT
<213> Homo sapiens
<308> O14735
<400> 2182

Met Pro Asp Glu Asn Ile Phe Leu Phe Val Pro Asn Leu Ile Gly Tyr 
  1               5                  10                  15
Ala Arg Ile Val Phe Ala Ile Ile Ser Phe Tyr Phe Met Pro Cys Cys 
             20                  25                  30
Pro Leu Thr Ala Ser Ser Phe Tyr Leu Leu Ser Gly Leu Leu Asp Ala 
         35                  40                  45
Phe Asp Gly His Ala Ala Arg Ala Leu Asn Gln Gly Thr Arg Phe Gly 
     50                  55                  60
Ala Met Leu Asp Met Leu Thr Asp Arg Cys Ser Thr Met Cys Leu Leu 
 65                  70                  75                  80
Val Asn Leu Ala Leu Leu Tyr Pro Gly Ala Thr Leu Phe Phe Gln Ile 
                 85                  90                  95
Ser Met Ser Leu Asp Val Ala Ser His Trp Leu His Leu His Ser Ser 
             100                105                110
Val Val Arg Gly Ser Glu Ser His Lys Met Ile Asp Leu Ser Gly Asn 
         115                120                125
Pro Val Leu Arg Ile Tyr Tyr Thr Ser Arg Pro Ala Leu Phe Thr Leu 
     130                135                140
Cys Ala Gly Asn Glu Leu Phe Tyr Cys Leu Leu Tyr Leu Phe His Phe 
 145                150                155                160
Ser Glu Gly Pro Leu Val Gly Ser Val Gly Leu Phe Arg Met Gly Leu 
                 165                170                175
Trp Val Thr Ala Pro Ile Ala Leu Leu Lys Ser Leu Ile Ser Val Ile 
             180                185                190
His Leu Ile Thr Ala Ala Arg Asn Met Ala Ala Leu Asp Ala Ala Asp 
         195                200                205
Arg Ala Lys Lys Lys 
     210



<210> 2183
<211> 1621
<212> DNA
<213> Rattus norvegicus
<308> D82928
<400> 2183

gtggatcgc  cgggagaac  gggcccagg  ctcaggtgg  gctgccgat  ccccgggct  60
aaaggtgag  ccacgctgg  gaggctggg  caagacctt  cacctccag  cctgggccg  120
gaccacaag  ggagccgcc  agatgccag  ggaaaatat  ttcctgttc  tgcctaatc  180
tattggtta  gcccggatt  ttttcgcca  catttcctt  tactttatg  cctgctgcc  240
cttcacggc  tcctccttc  atctactca  cggacttct  gacgctttc  atggacacg  300
agctcgagc  cttaatcaa  gaacccgat  tggggccat  ctcgacatg  tgacggacc  360
ttgcgccac  atgtgtctc  tggtcaacc  ggccctgct  taccctcgg  ccactcttc  420
gttccagct  agcatgagc  tggacgtgg  cagtcactg  ctgcatctg  acagttctg  480
ggtgcgagg  agtgagagc  acaagatga  tgacctgtc  gggaaccct  tgcttcgaa  540
ctactatac  tccaggcct  ctctgttca  cctgtgtgc  ggaaatgaa  tcttctact  600
cctcctgta  ctgttcaat  tctccgagg  accactagt  ggctctgtg  ggcttttcc  660
aatgggcct  tggatcaca  ctcccattg  cctgctcaa  tccatcatt  gtgtcatcc  720
cctcgtcac  gctgcaagg  acatggctg  cctcgatgc  gcagaccgc  ccaagaaga  780
atgatcctc  cccatcccc  gctgcccac  tgccctggg  atctactgt  ccacatggc  840
cctctcctc  taagaggtc  cagtgtcat  tctttctca  gtgttctct  acctgctgg  900
attgggggt  accctctgt  tggtgttgt  actgtcttt  tactcctga  aactagacc  960
aacccgtga  cccaaggac  tggcactgc  aagcaggaa  ggtgctcag  aggcccact  1020
atccagccg  tgctccagg  ggcctgtct  aagactggg  gttgccaca  atcctgctg  1080
atcagcctg  ggtctggcc  gagactttg  gaacttata  gggcaaagg  gtcaggctg  1140
tgggccaag  aggctgggg  accaggcca  ggagggaag  ggccaaggg  caactagat  1200
tttccctta  gcaagctcc  ctatcctgt  ctgctctgg  aacctccat  ataaagggg  1260
gcaccttca  tctttttgg  tttgtttac  ttgggacac  cttagatga  ggcctaggg  1320
tcaaaggag  tgggtaaaa  aaaaagaaa  ccacctgga  gcttttccc  caaaggtgg  1380
tggctcctc  ctgtcattc  agtgacctc  gagaggcct  gaggttcac  agcgttgtc  1440
tgcccacct  ctctatgtc  tggctggcc  ctttcactg  aaccttgat  tttttgacc  1500
tcatgagaa  gtaagcttc  caagagcag  tttagatct  tctcgtctc  gcctggagt  1560
aaaagtagc  tggcatgtg  taactgctt  ataaatatt  atggaaaga  gaaaaaaat  1620
c  1621



<210> 2184
<211> 213
<212> PRT
<213> Rattus norvegicus
<308> P70500
<400> 2184

Met Pro Glu Glu Asn Ile Phe Leu Phe Val Pro Asn Leu Ile Gly Tyr 
  1               5                  10                  15
Ala Arg Ile Val Phe Ala Ile Ile Ser Phe Tyr Phe Met Pro Cys Cys 
             20                  25                  30
Pro Phe Thr Ala Ser Ser Phe Tyr Leu Leu Ser Gly Leu Leu Asp Ala 
         35                  40                  45
Phe Asp Gly His Ala Ala Arg Ala Leu Asn Gln Gly Thr Arg Phe Gly 
     50                  55                  60
Ala Met Leu Asp Met Leu Thr Asp Arg Cys Ala Thr Met Cys Leu Leu 
 65                  70                  75                  80
Val Asn Leu Ala Leu Leu Tyr Pro Arg Ala Thr Leu Leu Phe Gln Leu 
                 85                  90                  95
Ser Met Ser Leu Asp Val Ala Ser His Trp Leu His Leu His Ser Ser 
             100                105                110
Val Val Arg Gly Ser Glu Ser His Lys Met Ile Asp Leu Ser Gly Asn 
         115                120                125
Pro Val Leu Arg Ile Tyr Tyr Thr Ser Arg Pro Ala Leu Phe Thr Leu 
     130                135                140
Cys Ala Gly Asn Glu Leu Phe Tyr Cys Leu Leu Tyr Leu Phe Asn Phe 
 145                150                155                160
Ser Glu Gly Pro Leu Val Gly Ser Val Gly Leu Phe Arg Met Gly Leu 
                 165                170                175
Trp Ile Thr Ala Pro Ile Ala Leu Leu Lys Ser Ile Ile Ser Val Ile 
             180                185                190
His Leu Val Thr Ala Ala Arg Asn Met Ala Ala Leu Asp Ala Ala Asp 
         195                200                205
Arg Ala Lys Lys Lys 
     210



<210> 2185
<211> 1833
<212> DNA
<213> Homo sapiens
<308> AF014807
<400> 2185

gaattcggc  cgaggcgcg  aggaggagg  tcccggaag  cacgcgcac  gggagcagc  60
gcgaccgca  ctggaggcc  ggagcgcct  cggggctgg  agaggcgag  gaggttgcg  120
gtaggaagg  cgggactgc  cgcgccccc  gcgtcccgc  cacctcggg  ccggtccat  180
ctcccgacg  ctgcgggct  cagcatctg  ggccaggtt  gggcggcgg  gtccagggc  240
cagtggtgc  gccgatgcg  cggggccgg  gctgaaggc  gcgctgcgg  gctgggaca  300
cactggcat  tccagagca  gcccggggc  gcaagggag  cgccgcgat  ccagacgaa  360
atatcttcc  gttcgtgcc  aacctcatc  gttatgccc  gattgtctt  gccatcatt  420
ctttctact  catgccctg  tgccccctc  cggcctcct  cttctacct  ctcagcggc  480
tgctggacg  tttcgatgg  cacgctgct  gcgctctta  tcaaggaac  cggtttggg  540
ccatgctgg  catgctgac  gaccgctgc  ccaccatgt  cctgttggt  aacctggcc  600
tgctgtacc  tggagccac  ctgttcttc  aaatcagca  gagtttgga  gtggccagt  660
actggctgc  cctccacag  tctgtggtc  gaggcagtg  gagtcacaa  atgatcgac  720
tgtccggga  tccggtgct  cggatctac  acacctcga  gcctgctct  ttcaccttg  780
gtgctggga  tgagctctt  tactgcctc  tctacctgt  ccatttctc  gagggacct  840
tagttggct  tgtgggact  ttccggatg  gcctctggg  cactgcccc  atcgccttg  900
tgaagtcgc  catcagcgt  atccacctg  tcacggccg  ccgcaacat  gctgccctg  960
acgcagcag  ccgcgccaa  aagaagtga  gctggagcc  cgggtcctg  ctgcccacc  1020
gccctggga  tcttgctgt  ccacacagc  ccccacccc  tgctaggag  tcccagtct  1080
acgccttcc  catgtgttg  tctacctgc  gggatgggg  tcagcctct  tttggtgac  1140
tcacgttct  tgggatcct  aggacccgg  cctcaaatc  gggaggata  gcgggaggc  1200
ccctccatc  aggcggtgc  cctggggtg  cgggaccgg  cagtgtcac  ccctgcctg  1260
tcagtcctg  ggtccgaga  gctagggac  cttgagtga  ggaggtggt  tgagggcca  1320
gtttcctga  aggcgggag  cagacctcc  cccccagcc  gagcaagct  ggggcacca  1380
gcccaggag  gaagaagcc  tccacagcc  tccctgtca  cggctcctc  gtcctgcct  1440
accctggtc  tggcgggac  tcactattt  acttggttt  ctttcagat  ttcttggct  1500
agggcctgg  ttgagggag  ttagggaag  acgtccgtc  gggtgcttt  cctccagtt  1560
gctggctgg  ttctccgtc  acccacagt  acctcacag  gaggccctc  tgccaccca  1620
gctcatgtg  tgtccccac  gcccacttg  ttgatgtca  tgactgtct  catgtattt  1680
tattcttga  attttctac  ctcactaga  tgtaaactc  atgaaggca  agacttttc  1740
tgttctctt  tctatccct  gagtaagac  aacttgaac  tggcatata  tagctgctt  1800
ataaatact  gtctgtcaa  aaaaaaaaa  aaa  1833



<210> 2186
<211> 213
<212> PRT
<213> Homo sapiens
<308> O14735
<400> 2186

Met Pro Asp Glu Asn Ile Phe Leu Phe Val Pro Asn Leu Ile Gly Tyr 
  1               5                  10                  15
Ala Arg Ile Val Phe Ala Ile Ile Ser Phe Tyr Phe Met Pro Cys Cys 
             20                  25                  30
Pro Leu Thr Ala Ser Ser Phe Tyr Leu Leu Ser Gly Leu Leu Asp Ala 
         35                  40                  45
Phe Asp Gly His Ala Ala Arg Ala Leu Asn Gln Gly Thr Arg Phe Gly 
     50                  55                  60
Ala Met Leu Asp Met Leu Thr Asp Arg Cys Ser Thr Met Cys Leu Leu 
 65                  70                  75                  80
Val Asn Leu Ala Leu Leu Tyr Pro Gly Ala Thr Leu Phe Phe Gln Ile 
                 85                  90                  95
Ser Met Ser Leu Asp Val Ala Ser His Trp Leu His Leu His Ser Ser 
             100                105                110
Val Val Arg Gly Ser Glu Ser His Lys Met Ile Asp Leu Ser Gly Asn 
         115                120                125
Pro Val Leu Arg Ile Tyr Tyr Thr Ser Arg Pro Ala Leu Phe Thr Leu 
     130                135                140
Cys Ala Gly Asn Glu Leu Phe Tyr Cys Leu Leu Tyr Leu Phe His Phe 
 145                150                155                160
Ser Glu Gly Pro Leu Val Gly Ser Val Gly Leu Phe Arg Met Gly Leu 
                 165                170                175
Trp Val Thr Ala Pro Ile Ala Leu Leu Lys Ser Leu Ile Ser Val Ile 
             180                185                190
His Leu Ile Thr Ala Ala Arg Asn Met Ala Ala Leu Asp Ala Ala Asp 
         195                200                205
Arg Ala Lys Lys Lys 
     210



<210> 2187
<211> 6857
<212> DNA
<213> Rattus norvegicus
<308> D83538
<400> 2187

ttccagaat  gatagtggt  cggcccacc  ctgaaggtt  cagaatcga  agtggttcg  60
cccacctct  aaggttcca  aatcgatag  ggttcggcc  acctctgaa  gttccagaa  120
cgatagtgg  tcggcccac  tctgatggt  ccagcacct  ccgaggttt  tatttcaac  180
cagtgcttt  actggcccg  tccctggct  tgcagagac  tgcatccct  gagaaggtt  240
aaaattcgg  ccacctctg  aggttccag  atcgatagg  tctggttcc  gcacctccc  300
aggttttta  ttcaacaca  tgccttcac  ggcccgctc  ctggctgtg  agagacctg  360
atccttaga  aaggttcaa  agctgctgt  catgtgccc  gtagatttt  atggaatct  420
ccagctaga  gaaagacgg  gagatgcag  gattgctct  ggcattttt  tcattgagt  480
tgatcttca  cacaaagat  gtattgttc  ttatcttct  cgacttctc  ggggtcttc  540
aaaagtcta  tgggtagaa  aaagcacag  tcggaaagg  agaggtaac  tcccggttg  600
agaaagctt  agcttctgc  tggtgacct  gctgtctga  gtggcttgc  gggacccct  660
gcttaggga  gagatttta  aggcacttt  gcaggtttt  catgtcctt  tggggatgt  720
ccaggccct  gagattcaa  agaaagaat  cctttgcaa  tatgcaatc  catgcctga  780
agggatctc  aaatctttt  gacgttaca  caattcaga  gaatctctc  tctcaaagc  840
ttttcccaa  gtccctcct  attccctga  aatccccga  gagctagaa  gtgtccgaa  900
gcgttcctt  aatgacttc  gctccatcc  gcccagcaa  ctgctgact  tctgtcagg  960
gggcacact  aagaggaaa  ccagcagtg  gtccagcat  tctcaggtt  gcccagaac  1020
tggcatgcc  cctcccagc  cccctggag  atctgcttt  cactatttt  aagcctctt  1080
cctgcctga  ggaaccacc  tggagcccg  atactactt  tctaccatc  gctccagtt  1140
ttctgtctc  cccctgttc  atggtatca  ctataagga  ttctatatt  cactggaaa  1200
gcttcgaga  ctcttaaac  tggtaaaga  gattgttga  gagcctgtt  tcaagtcct  1260
agatgcagc  gtagccaga  tgatggagg  caatcccag  gctgaccta  actacacga  1320
cttcagtga  cccgtctac  tgaccatgt  caagatgct  cgagacact  tgtactata  1380
gaaagactt  cccacctcc  ttgtgaaag  gatccatga  tttgtgttg  agcagttca  1440
catgagcca  ggggaactc  aaaagattc  ccatgatgc  gacaggatc  acagtgaga  1500
gagcccact  aaactgcgc  gccaagcaa  tgctgcctg  gtagacctc  tggtgtggg  1560
tgtgaagga  gagcagggt  cagaaaacc  ttgcatcaa  ctgtctgaa  agctgcagt  1620
caagacatc  agcaaggtc  tcatcgccc  tttgccctt  ctgatctgc  gcctacagg  1680
tctgggccg  ctatgtgaa  ggttcccgg  ggtggtcca  tcagtgaca  catctttga  1740
agactttct  gtgattcca  ccccagtgc  ggtgaagct  tataagtac  acagtcagt  1800
ccacacagt  gctggcagt  atataaaaa  tagtgtcac  aatgagcat  ctgagtcaa  1860
tctgaatgt  ttgcccggc  agaagaacc  gccatccat  tatgagcag  tccgggaca  1920
cgccattga  aacatctgc  ggtgcctga  ggccggcct  accgtggac  ctgtgatcg  1980
ggaggcctt  ctggccagc  tctccaacc  gctctatat  tcccaggag  gcgataagg  2040
tgctcactt  attcctgac  ataccattc  tgccttggg  cacattgca  tggctctga  2100
ggatacccc  aaggtcatg  agccaattc  gcagcagaa  ttttgccag  ccccctcac  2160
cctcgatgt  ctcatcatc  accagctgg  ctgcctggt  atcactgga  atcaataca  2220
ttatcagga  gtgtggaat  tcttccaac  aatcagtgt  aaggccagt  cagttgtat  2280
ttcagccac  aaagactac  aagaccatg  ctacaggca  tgctccctc  cagtcatca  2340
tgccctggc  aacatcgca  ccaacattc  ggaggagca  cttgtggat  agctgttga  2400
gaacctgct  gaactgttt  tgcagctgg  gctggaggg  aagagagcc  gtgagaggg  2460
cagcgagaa  gggcccgcc  tgaaggctt  cagcagtgc  gggaatttg  gagtgctca  2520
tcctgtaat  gccgtgctc  cccgacgat  gccacccat  aaagaagct  aacctaggc  2580
acaaaagct  ttccgagac  tctggctct  ctctgtgct  atgggattc  ctgtggaag  2640
ctcagggct  tggccggaa  agtggtatg  aggagtctg  gaaatagca  ccaagtcac  2700
tctgcttac  tttcccagc  aagagcctc  tcgatcagt  ctccagtac  actcagcca  2760
gaaaaatga  acagtgacc  cggctgagc  gaatgagct  cgaagtacc  tcatcaact  2820
gctagatcc  cctcctgag  tgtctgccc  catcaacaa  ctggacttt  ccatgtcca  2880
ctatctctt  tctgtgtat  ggctggaat  catgagggt  ctgcgttct  cagatccag  2940
tcgcttcca  gtaatgttc  gctacttcg  ggataaagc  attcagaaa  acaaatctg  3000
gatgatgca  tgtgtcatc  ctgttgctg  caaagtatt  gatgccttc  tgaacatga  3060
ggcagaaaa  gccaagacc  aggagaatg  agaggagtt  gagcggcat  cccagtttc  3120
gctggtgaa  ttcaaccac  ttcacaaga  gatacgcag  gtggctgac  agtacctgt  3180
tggtctggt  gataagttt  cacacttgc  ctggagtgg  actgtgctg  agaccatgt  3240
ggacatcct  cagaccctg  cactatcac  aagtgctga  attcacaag  accaacctt  3300
ttatgacat  cctgacgcc  cctatcgga  cacggttcc  gacacgtat  aagcccggg  3360
gagcatcgt  aaagacttt  ctgcacgct  tgggatgat  ctgcaggaa  ccatgaagt  3420
ggcacccac  gtcactaag  cccacctgc  ggaatatct  aacaagcat  agaactggg  3480
gtcaggact  tcccagcac  cgggattgg  catggccac  gagagcatc  ttcactttg  3540
cggctacaa  aagcagaac  caactcttg  ggtaactca  ctcactgag  gcccggcct  3600
tgtgaagaa  gactactcc  acttcatgg  atccttgaa  ttgcgcaac  gctatgccg  3660
cgaggtgca  gggatgatt  ggttctcag  tgccacagg  cagatgtcc  acctgaaca  3720
aatgatggt  caggatctg  ttacagctc  ggaccacag  catcctcag  actataccc  3780
agccatgtt  aaattgacg  ccatgctca  tagcagcaa  gattgtgac  cacagctcc  3840
tcatcatct  tgttggggt  ccctccgga  gttcaacga  catggcatg  agactgcac  3900
agcctgctg  gagtggctg  tggctggca  gaatggagt  gaagtgccg  tcatgcggg  3960
gatggcagg  gcctggcac  tgacagtgg  gcagaagtt  ggcctcttc  ctgcagaaa  4020
aaaggaagc  gaccccctg  cagcgtcag  agcaagtca  ccacgaccc  gtccccctg  4080
agtgacacc  cactacatc  ggattgatt  cctggtgca  cggtttgag  ttgccaagt  4140
ctgtagctc  gaccaggtg  agatcttct  aagcctgct  cagcgctcc  tgtccctcc  4200
catcggtgg  gccaggggg  gcatgaaca  gcatgtggc  gccattgga  cacgtttca  4260
actgctgac  ctggggctg  ccctcctac  cgctgatgt  gttccaaat  caaccattc  4320
aaacgtgct  cgagagaag  tctactcaa  agcctttga  tatttcagt  gtccaccaa  4380
gttccctac  caaggagaa  agaggctgc  tgaagatat  agcatcatg  ttaagtttt  4440
gactgccat  ttctcagat  agaagtacc  gactgccag  caactcgtt  ccccagata  4500
ccaggacac  cgaagcaac  tggatataa  tgtgggctc  cgacaacag  ctacacagg  4560
atggatcaa  acatacccc  tctccagtg  catgtcaac  atctccaaa  aatcaggca  4620
gtctaagaa  accaaccga  gttcccagc  gcacaagta  tacatgaag  gtaggacgc  4680
gctgctgtc  ctgttggcc  ctgagatcg  gcgcctcat  acttggtac  acccgctgt  4740
agccccaga  ctagagctg  accaggcag  tgagaacag  gttgccaac  ggaggtcca  4800
gtatatcag  ctgagtgag  agcagtgga  ggacaacgt  aaccttgcc  ggaccatct  4860
tccatacct  gctgtgcag  tgccagcca  gttcaagaa  acagaagcc  ttggaaatg  4920
agtgacccg  ctcgttcgc  tggacccag  agctgttag  gatgtccct  aagctatca  4980
gttccttgt  acctggcac  ccatcgatg  tgatgctcc  gagcttagc  atgtgttat  5040
ctgggcacc  acggacccg  ccacgggcc  ctcctactt  tccagcatg  accccccac  5100
ccctctcac  gcacagtat  gggtgaaag  cctgcggtc  ttccctccg  atgccattc  5160
gttctacat  ccccagatt  tgcaggccc  cagatatga  aagatgggc  atgtgcgcg  5220
gtacattct  tgggctgca  ccaaatccc  gcttctggc  caccagttt  tttggaata  5280
gaaaactaa  atctacctt  atgaagaag  gcaccagaa  gaccctgac  ttggtgacc  5340
tctggagca  ttagtagaa  aaatcacag  gtctctatc  ggcccagcc  aagatttct  5400
tcaacggga  tttgatttc  ttaacaaga  caccaacgt  tcagctatc  tcaagccct  5460
ccctaaagg  gatgaaaga  agaaggctt  tctgtcagc  ctgtctgaa  tgaaggtgc  5520
gcctggctg  tacctgccc  gcaaccctg  agcaattgt  ctagacatt  actacaagt  5580
agggacacc  atgcagagt  ctgcaaaag  gccgtatct  gccaagttt  aggtgaagc  5640
atgcggagt  agtgaactt  aaaaagaag  tctgcagtg  cgctcagac  cagaggatg  5700
gtgccgcag  caagaggct  atggcaaga  gatctgctg  caagcagcc  tcttcaaag  5760
gggggatga  tgccgacag  acatgctag  cctgcagat  atcgacctt  tcaagaaca  5820
cttccagct  gttggcctg  acctcttcg  ttttcccta  cgggtagtg  ctactgccc  5880
tgggtgtgg  gtgattgag  gcattccag  ctgtacctc  cgagaccag  taggccgcc  5940
gactgactt  ggcatgtat  actacttta  acgccagta  ggggacgag  ctaccttgg  6000
cttccagca  gcacgctac  actttatca  aagcatggc  gcctacagc  tcctgctgt  6060
cctgctgca  atcaaggac  ggcacaacg  caacatcat  ctggacaag  agggacaca  6120
catccacat  gactttggc  tcatgtttg  aagctcacc  ggtggcaac  ttggctggg  6180
gccagacat  aagctgaca  acgagatgg  gatgattat  gggggcaag  tggaagcca  6240
acccttcaa  tggttcatg  agatgtgcg  ccgaggtta  ctggctgtg  gcccctata  6300
ggatgcagt  gtctccctg  ttacactca  gttggacac  ggcctgccc  gtttccgtg  6360
ccagacaat  aaacttttg  aacacaggt  cagcccgaa  atgacagag  gggaggctg  6420
aaattttat  atgaagatc  tccaaaact  tttcctcag  aacaggagc  ggacctacg  6480
catgatcca  tactaccag  atgatatcc  ctactgagg  gactgtacc  gaagccttg  6540
gtgtcacag  gcagcttgt  ctgtcacca  aagcctggg  gtggaggtg  caggcacat  6600
gaacttgga  gcacaggtg  gagtctttt  cacactgga  acattccct  tttgttcac  6660
catcttact  tgttggtac  tgaagtatt  tcctgtgta  acatgagaa  ttgacataa  6720
aaataagaa  cctaaaatg  gctacttct  tttgttagg  caccaagac  ttgtcctta  6780
tcaaaggta  cctttgaat  cctggtcct  ccaactcac  cctagctta  tcttgcttt  6840
atttggtcc  gaggatc  6857



<210> 2188
<211> 2041
<212> PRT
<213> Rattus norvegicus
<308> BAA19614
<400> 2188

Met Cys Pro Val Asp Phe His Gly Ile Phe Gln Leu Asp Glu Arg Arg 
  1               5                  10                  15
Arg Asp Ala Val Ile Ala Leu Gly Ile Phe Leu Ile Glu Ser Asp Leu 
             20                  25                  30
Gln His Lys Asp Cys Ile Val Pro Tyr Leu Leu Arg Leu Leu Arg Gly 
         35                  40                  45
Leu Pro Lys Val Tyr Trp Val Glu Glu Ser Thr Ala Arg Lys Gly Arg 
     50                  55                  60
Gly Asn Leu Pro Val Ala Glu Ser Phe Ser Phe Cys Leu Val Thr Leu 
 65                  70                  75                  80
Leu Ser Asp Val Ala Cys Arg Asp Pro Ser Leu Arg Asp Glu Ile Leu 
                 85                  90                  95
Glu Ala Leu Leu Gln Val Leu His Val Leu Leu Gly Met Cys Gln Ala 
             100                105                110
Leu Glu Ile Gln Glu Lys Glu Tyr Leu Cys Lys Tyr Ala Ile Pro Cys 
         115                120                125
Leu Ile Gly Ile Ser Lys Ser Phe Gly Arg Tyr Ser Asn Ser Glu Glu 
     130                135                140
Ser Leu Leu Ser Lys Leu Phe Pro Lys Val Pro Pro His Ser Leu Arg 
 145                150                155                160
Ile Pro Glu Glu Leu Glu Gly Val Arg Arg Arg Ser Phe Asn Asp Phe 
                 165                170                175
Arg Ser Ile Leu Pro Ser Asn Leu Leu Thr Val Cys Gln Glu Gly Thr 
             180                185                190
Leu Lys Arg Lys Thr Ser Ser Val Ser Ser Ile Ser Gln Val Ser Pro 
         195                200                205
Glu Arg Gly Met Pro Pro Pro Ser Ser Pro Gly Gly Ser Ala Phe His 
     210                215                220
Tyr Phe Glu Ala Ser Cys Leu Pro Asp Gly Thr Thr Leu Glu Pro Glu 
 225                230                235                240
Tyr Tyr Phe Ser Thr Ile Ser Ser Ser Phe Ser Val Ser Pro Leu Phe 
                 245                250                255
Asn Gly Ile Thr Tyr Lys Glu Phe Tyr Ile Pro Leu Glu Met Leu Arg 
             260                265                270
Glu Leu Leu Asn Leu Val Lys Lys Ile Val Glu Glu Pro Val Leu Lys 
         275                280                285
Ser Leu Asp Ala Ala Val Ala Arg Val Met Glu Ala Asn Pro Ser Ala 
     290                295                300
Asp Leu Tyr Tyr Thr Thr Phe Ser Asp Pro Val Tyr Leu Thr Met Phe 
 305                310                315                320
Lys Met Leu Arg Asp Thr Leu Tyr Tyr Met Lys Asp Leu Pro Thr Ser 
                 325                330                335
Phe Val Lys Glu Ile His Asp Phe Val Leu Glu Gln Phe Asn Met Ser 
             340                345                350
Gln Gly Glu Leu Gln Lys Ile Leu His Asp Ala Asp Arg Ile His Ser 
         355                360                365
Glu Met Ser Pro Leu Lys Leu Arg Cys Gln Ala Asn Ala Ala Cys Val 
     370                375                380
Asp Leu Met Val Trp Ala Val Lys Asp Glu Gln Gly Ala Glu Asn Leu 
 385                390                395                400
Cys Ile Lys Leu Ser Glu Lys Leu Gln Ser Lys Thr Ser Ser Lys Val 
                 405                410                415
Ile Ile Ala His Leu Pro Leu Leu Ile Cys Cys Leu Gln Gly Leu Gly 
             420                425                430
Arg Leu Cys Glu Arg Phe Pro Val Val Val His Ser Val Thr Pro Ser 
         435                440                445
Leu Arg Asp Phe Leu Val Ile Pro Ser Pro Val Leu Val Lys Leu Tyr 
     450                455                460
Lys Tyr His Ser Gln Tyr His Thr Val Ala Gly Ser Asp Ile Lys Ile 
 465                470                475                480
Ser Val Thr Asn Glu His Ser Glu Ser Thr Leu Asn Val Leu Pro Gly 
                 485                490                495
Lys Lys Asn Gln Pro Ser Met Tyr Glu Gln Leu Arg Asp Ile Ala Ile 
             500                505                510
Asp Asn Ile Cys Arg Cys Leu Lys Ala Gly Leu Thr Val Asp Pro Val 
         515                520                525
Ile Val Glu Ala Phe Leu Ala Ser Leu Ser Asn Arg Leu Tyr Ile Ser 
     530                535                540
Gln Glu Ser Asp Lys Asp Ala His Leu Ile Pro Asp His Thr Ile Arg 
 545                550                555                560
Ala Leu Gly His Ile Ala Val Ala Leu Arg Asp Thr Pro Lys Val Met 
                 565                570                575
Glu Pro Ile Leu Gln Gln Lys Phe Cys Gln Pro Pro Ser Pro Leu Asp 
             580                585                590
Val Leu Ile Ile Asp Gln Leu Gly Cys Leu Val Ile Thr Gly Asn Gln 
         595                600                605
Tyr Ile Tyr Gln Glu Val Trp Asn Leu Phe Gln Gln Ile Ser Val Lys 
     610                615                620
Ala Ser Ser Val Val Tyr Ser Ala Thr Lys Asp Tyr Lys Asp His Gly 
 625                630                635                640
Tyr Arg His Cys Ser Leu Ala Val Ile Asn Ala Leu Ala Asn Ile Ala 
                 645                650                655
Ala Asn Ile Gln Glu Glu His Leu Val Asp Glu Leu Leu Met Asn Leu 
             660                665                670
Leu Glu Leu Phe Val Gln Leu Gly Leu Glu Gly Lys Arg Ala Ser Glu 
         675                680                685
Arg Ala Ser Glu Lys Gly Pro Ala Leu Lys Ala Ser Ser Ser Ala Gly 
     690                695                700
Asn Leu Gly Val Leu Ile Pro Val Ile Ala Val Leu Thr Arg Arg Leu 
 705                710                715                720
Pro Pro Ile Lys Glu Ala Lys Pro Arg Leu Gln Lys Leu Phe Arg Asp 
                 725                730                735
Phe Trp Leu Tyr Ser Val Leu Met Gly Phe Ala Val Glu Gly Ser Gly 
             740                745                750
Leu Trp Pro Glu Glu Trp Tyr Glu Gly Val Cys Glu Ile Ala Thr Lys 
         755                760                765
Ser Pro Leu Leu Thr Phe Pro Ser Lys Glu Pro Leu Arg Ser Val Leu 
     770                775                780
Gln Tyr Asn Ser Ala Met Lys Asn Asp Thr Val Thr Pro Ala Glu Leu 
 785                790                795                800
Asn Glu Leu Arg Ser Thr Ile Ile Asn Leu Leu Asp Pro Pro Pro Glu 
                 805                810                815
Val Ser Ala Leu Ile Asn Lys Leu Asp Phe Ala Met Ser Thr Tyr Leu 
             820                825                830
Leu Ser Val Tyr Arg Leu Glu Tyr Met Arg Val Leu Arg Ser Thr Asp 
         835                840                845
Pro Asp Arg Phe Gln Val Met Phe Cys Tyr Phe Glu Asp Lys Ala Ile 
     850                855                860
Gln Lys Asp Lys Ser Gly Met Met Gln Cys Val Ile Ala Val Ala Asp 
 865                870                875                880
Lys Val Phe Asp Ala Phe Leu Asn Met Met Ala Glu Lys Ala Lys Thr 
                 885                890                895
Lys Glu Asn Glu Glu Glu Leu Glu Arg His Ala Gln Phe Leu Leu Val 
             900                905                910
Asn Phe Asn His Ile His Lys Arg Ile Arg Arg Val Ala Asp Lys Tyr 
         915                920                925
Leu Ser Gly Leu Val Asp Lys Phe Pro His Leu Leu Trp Ser Gly Thr 
     930                935                940
Val Leu Lys Thr Met Leu Asp Ile Leu Gln Thr Leu Ser Leu Ser Leu 
 945                950                955                960
Ser Ala Asp Ile His Lys Asp Gln Pro Tyr Tyr Asp Ile Pro Asp Ala 
                 965                970                975
Pro Tyr Arg Ile Thr Val Pro Asp Thr Tyr Glu Ala Arg Glu Ser Ile 
             980                985                990
Val Lys Asp Phe Ala Ala Arg Cys Gly Met Ile Leu Gln Glu Ala Met 
         995                1000                1005
Lys Trp Ala Pro Thr Val Thr Lys Ser His Leu Gln Glu Tyr Leu Asn 
     1010                1015                1020
Lys His Gln Asn Trp Val Ser Gly Leu Ser Gln His Thr Gly Leu Ala 
 1025                1030                1035                1040
Met Ala Thr Glu Ser Ile Leu His Phe Ala Gly Tyr Asn Lys Gln Asn 
                 1045                1050                1055
Thr Thr Leu Gly Val Thr Gln Leu Thr Glu Arg Pro Ala Cys Val Lys 
             1060                1065                1070
Lys Asp Tyr Ser Asn Phe Met Ala Ser Leu Asn Leu Arg Asn Arg Tyr 
         1075                1080                1085
Ala Gly Glu Val His Gly Met Ile Arg Phe Ser Gly Ala Thr Gly Gln 
     1090                1095                1100
Met Ser Asp Leu Asn Lys Met Met Val Gln Asp Leu Ile Thr Ala Leu 
 1105                1110                1115                1120
Asp His Ser His Pro Gln His Tyr Thr Gln Ala Met Phe Lys Leu Thr 
                 1125                1130                1135
Ala Met Leu Ile Ser Ser Lys Asp Cys Asp Pro Gln Leu Leu His His 
             1140                1145                1150
Leu Cys Trp Gly Pro Leu Arg Met Phe Asn Glu His Gly Met Glu Thr 
         1155                1160                1165
Ala Leu Ala Cys Trp Glu Trp Leu Leu Ala Gly Lys Asn Gly Val Glu 
     1170                1175                1180
Val Pro Phe Met Arg Glu Met Ala Gly Ala Trp His Met Thr Val Glu 
 1185                1190                1195                1200
Gln Lys Phe Gly Leu Phe Ser Ala Glu Thr Lys Glu Ala Asp Pro Leu 
                 1205                1210                1215
Ala Ala Ser Glu Ala Ser Gln Pro Arg Pro Cys Pro Pro Glu Val Thr 
             1220                1225                1230
Pro His Tyr Ile Trp Ile Asp Phe Leu Val Gln Arg Phe Glu Ile Ala 
         1235                1240                1245
Lys Tyr Cys Ser Ser Asp Gln Val Glu Ile Phe Ser Ser Leu Leu Gln 
     1250                1255                1260
Arg Ser Met Ser Leu His Ile Gly Gly Ala Arg Gly Ser Met Asn Arg 
 1265                1270                1275                1280
His Val Ala Ala Ile Gly Pro Arg Phe Lys Leu Leu Thr Leu Gly Leu 
                 1285                1290                1295
Ser Leu Leu His Ala Asp Val Val Pro Asn Ala Thr Ile Arg Asn Val 
             1300                1305                1310
Leu Arg Glu Lys Ile Tyr Ser Thr Ala Phe Asp Tyr Phe Ser Cys Pro 
         1315                1320                1325
Pro Lys Phe Pro Thr Gln Gly Glu Lys Arg Leu Arg Glu Asp Ile Ser 
     1330                1335                1340
Ile Met Ile Lys Phe Trp Thr Ala Met Phe Ser Asp Lys Lys Tyr Leu 
 1345                1350                1355                1360
Thr Ala Ser Gln Leu Val Pro Pro Asp Asn Gln Asp Thr Arg Ser Asn 
                 1365                1370                1375
Leu Asp Ile Thr Val Gly Ser Arg Gln Gln Ala Thr Gln Gly Trp Ile 
             1380                1385                1390
Asn Thr Tyr Pro Leu Ser Ser Gly Met Ser Thr Ile Ser Lys Lys Ser 
         1395                1400                1405
Gly Met Ser Lys Lys Thr Asn Arg Gly Ser Gln Leu His Lys Tyr Tyr 
     1410                1415                1420
Met Lys Arg Arg Thr Leu Leu Leu Ser Leu Leu Ala Thr Glu Ile Glu 
 1425                1430                1435                1440
Arg Leu Ile Thr Trp Tyr Asn Pro Leu Ser Ala Pro Glu Leu Glu Leu 
                 1445                1450                1455
Asp Gln Ala Gly Glu Asn Ser Val Ala Asn Trp Arg Ser Lys Tyr Ile 
             1460                1465                1470
Ser Leu Ser Glu Lys Gln Trp Lys Asp Asn Val Asn Leu Ala Trp Thr 
         1475                1480                1485
Ile Ser Pro Tyr Leu Ala Val Gln Leu Pro Ala Arg Phe Lys Asn Thr 
     1490                1495                1500
Glu Ala Ile Gly Asn Glu Val Thr Arg Leu Val Arg Leu Asp Pro Gly 
 1505                1510                1515                1520
Ala Val Ser Asp Val Pro Glu Ala Ile Lys Phe Leu Val Thr Trp His 
                 1525                1530                1535
Thr Ile Asp Ala Asp Ala Pro Glu Leu Ser His Val Leu Cys Trp Ala 
             1540                1545                1550
Pro Thr Asp Pro Pro Thr Gly Leu Ser Tyr Phe Ser Ser Met Tyr Pro 
         1555                1560                1565
Pro His Pro Leu Thr Ala Gln Tyr Gly Val Lys Val Leu Arg Ser Phe 
     1570                1575                1580
Pro Pro Asp Ala Ile Leu Phe Tyr Ile Pro Gln Ile Val Gln Ala Leu 
 1585                1590                1595                1600
Arg Tyr Asp Lys Met Gly Tyr Val Arg Glu Tyr Ile Leu Trp Ala Ala 
                 1605                1610                1615
Ala Lys Ser Gln Leu Leu Ala His Gln Phe Ile Trp Asn Met Lys Thr 
             1620                1625                1630
Asn Ile Tyr Leu Asp Glu Glu Gly His Gln Lys Asp Pro Asp Ile Gly 
         1635                1640                1645
Asp Leu Leu Glu Gln Leu Val Glu Glu Ile Thr Gly Ser Leu Ser Gly 
     1650                1655                1660
Pro Ala Lys Asp Phe Tyr Gln Arg Glu Phe Asp Phe Phe Asn Lys Ile 
 1665                1670                1675                1680
Thr Asn Val Ser Ala Ile Ile Lys Pro Tyr Pro Lys Gly Asp Glu Arg 
                 1685                1690                1695
Lys Lys Ala Cys Leu Ser Ala Leu Ser Glu Val Lys Val Gln Pro Gly 
             1700                1705                1710
Cys Tyr Leu Pro Ser Asn Pro Glu Ala Ile Val Leu Asp Ile Asp Tyr 
         1715                1720                1725
Lys Ser Gly Thr Pro Met Gln Ser Ala Ala Lys Ala Pro Tyr Leu Ala 
     1730                1735                1740
Lys Phe Lys Val Lys Arg Cys Gly Val Ser Glu Leu Glu Lys Glu Gly 
 1745                1750                1755                1760
Leu Gln Cys Arg Ser Asp Thr Glu Asp Glu Cys Arg Arg Gln Glu Ala 
                 1765                1770                1775
Asp Gly Lys Lys Ile Cys Trp Gln Ala Ala Ile Phe Lys Val Gly Asp 
             1780                1785                1790
Asp Cys Arg Gln Asp Met Leu Ala Leu Gln Ile Ile Asp Leu Phe Lys 
         1795                1800                1805
Asn Ile Phe Gln Leu Val Gly Leu Asp Leu Phe Val Phe Pro Tyr Arg 
     1810                1815                1820
Val Val Ala Thr Ala Pro Gly Cys Gly Val Ile Glu Cys Ile Pro Asp 
 1825                1830                1835                1840
Cys Thr Ser Arg Asp Gln Leu Gly Arg Gln Thr Asp Phe Gly Met Tyr 
                 1845                1850                1855
Asp Tyr Phe Thr Arg Gln Tyr Gly Asp Glu Ser Thr Leu Ala Phe Gln 
             1860                1865                1870
Gln Ala Arg Tyr Asn Phe Ile Arg Ser Met Ala Ala Tyr Ser Leu Leu 
         1875                1880                1885
Leu Phe Leu Leu Gln Ile Lys Asp Arg His Asn Gly Asn Ile Met Leu 
     1890                1895                1900
Asp Lys Lys Gly His Ile Ile His Ile Asp Phe Gly Phe Met Phe Glu 
 1905                1910                1915                1920
Ser Ser Pro Gly Gly Asn Leu Gly Trp Glu Pro Asp Ile Lys Leu Thr 
                 1925                1930                1935
Asp Glu Met Val Met Ile Met Gly Gly Lys Met Glu Ala Thr Pro Phe 
             1940                1945                1950
Lys Trp Phe Met Glu Met Cys Val Arg Gly Tyr Leu Ala Val Arg Pro 
         1955                1960                1965
Tyr Met Asp Ala Val Val Ser Leu Val Thr Leu Met Leu Asp Thr Gly 
     1970                1975                1980
Leu Pro Cys Phe Arg Gly Gln Thr Ile Lys Leu Leu Lys His Arg Phe 
 1985                1990                1995                2000
Ser Pro Asn Met Thr Glu Arg Glu Ala Ala Asn Phe Ile Met Lys Ile 
                 2005                2010                2015
Ile Gln Asn Cys Phe Leu Ser Asn Arg Ser Arg Thr Tyr Asp Met Ile 
             2020                2025                2030
Gln Tyr Tyr Gln Asn Asp Ile Pro Tyr 
         2035                2040



<210> 2189
<211> 1787
<212> DNA
<213> Homo sapiens
<308> AK024034
<400> 2189

aaaaaatta  ctgggcatg  tggtgggca  ctgtagtcc  agctactcg  gaggctgag  60
caggagaat  tcttgaacc  aggaggcag  ggttgcagt  agccaagat  atgccactg  120
actccagcc  ggcgacaga  cgagactcc  tttaaaaaa  aaaacacca  ggcatctgt  180
agccacttt  ggagtcaaa  gaatgtaga  ctgggctgg  ctccttaga  gaaagttaa  240
ttctgagtg  gggaggaag  gcctgcacc  ccacatcca  acagcccgt  actcctgct  300
ccgaagact  acttgctga  tcgggctct  cctccatag  gggggcaca  agccaggga  360
agtgcccac  ggcccaggg  tcctgggtg  gggaccagg  agaatgccc  caggcccca  420
ggccttttt  agcccaggg  gctctctgc  caggcctgc  acaacttca  ccgaagcat  480
gccgcctac  gcctcctgc  gttcctgct  cagatcaag  acagacaca  cggcaacat  540
atgctggac  agaagggcc  tatcatcca  atcggtcag  cagccacag  gccaccctc  600
tctcccttc  ccccggcac  caggggtgg  tagggatcc  caccccaca  agaggagaa  660
gcccaggac  accctgcca  gagtgtcag  gtccagctc  gaggtccga  ctgtcggcc  720
ccaagctgt  ctgctgtag  gggtgcctg  ccccggccc  agggagctg  ggcgagagc  780
gccattgct  tgagtcaga  gctggagct  ggcggagtg  ggctcgtcc  ggttcagtg  840
cccagcttg  ctccttcct  cacttcctc  cttctcttt  tctgcctgc  gccccacca  900
ccaccccat  actgtctcc  agaaaacac  acctgcctt  tgggggtgg  gggggtgct  960
ctgttgcag  gtccttttc  actcctcaa  acagaccac  cgtccttgc  cgccctggc  1020
cctacccag  cacaggcag  tctttggtg  tttgcagac  ttggcttca  gtttgaaag  1080
tcgccgggc  gcaatctcg  ctgggaacc  gacatcaag  tgacggatg  gatggtgat  1140
atcatgggg  gcaagatgg  ggccacacc  ttcaagtgg  tcatggaga  gtgtgtcca  1200
gctacctgg  tgtgcggcc  tacatggat  tggtcgtct  cctggtcac  atcatgttg  1260
acacgggcc  gccctgttt  cgcggccag  caatcaagt  cttgaagca  aggtttagc  1320
ccaacatga  tgagcgcga  gctgcaaat  tcatcatga  ggtcatcca  agctgcttc  1380
tcagcaaca  gagccggac  tacaacatg  tccagtact  tcagaatga  atcccctac  1440
gaggagggg  ccttcgagg  cctctgccc  atgtgccct  gaagctgcc  cacaatcat  1500
gagccctgc  acctacccg  cctgccgcc  catgcagtg  aggagaggc  tgtggcccg  1560
agagcctgg  agcgcctcc  ggggcagca  gtgggtggc  caggcttag  aacgccgtg  1620
actgcagcg  caatcagtg  atggtgctg  ctatgcaca  gtgtgagtc  tctgtttgc  1680
ctggacata  tccctacct  ttttatttc  taggtacat  aagtattgt  tataaaaaa  1740
gagataaga  ttaaccaac  tcaacaaaa  aaaaaccca  aatagtg  1787



<210> 2190
<211> 854
<212> PRT
<213> Homo sapiens
<308> P42356
<400> 2190

Met Arg Glu Met Ala Gly Ala Trp His Met Thr Val Glu Gln Lys Phe 
  1               5                  10                  15
Gly Leu Phe Ser Ala Glu Ile Lys Glu Ala Asp Pro Leu Ala Ala Ser 
             20                  25                  30
Glu Ala Ser Gln Pro Lys Pro Cys Pro Pro Glu Val Thr Pro His Tyr 
         35                  40                  45
Ile Trp Ile Asp Phe Leu Val Gln Arg Phe Glu Ile Ala Lys Tyr Cys 
     50                  55                  60
Ser Ser Asp Gln Val Glu Ile Phe Ser Ser Leu Leu Gln Arg Ser Met 
 65                  70                  75                  80
Ser Leu Asn Ile Gly Gly Ala Lys Gly Ser Met Asn Arg His Val Ala 
                 85                  90                  95
Ala Ile Gly Pro Arg Phe Lys Leu Leu Thr Leu Gly Leu Ser Leu Leu 
             100                105                110
His Ala Asp Val Val Pro Asn Ala Thr Ile Arg Asn Val Leu Arg Glu 
         115                120                125
Lys Ile Tyr Ser Thr Ala Phe Asp Tyr Phe Ser Cys Pro Pro Lys Phe 
     130                135                140
Pro Thr Gln Gly Glu Lys Arg Leu Arg Glu Asp Ile Ser Ile Met Ile 
 145                150                155                160
Lys Phe Trp Thr Ala Met Phe Ser Asp Lys Lys Tyr Leu Thr Ala Ser 
                 165                170                175
Gln Leu Val Pro Pro Asp Asn Gln Asp Thr Arg Ser Asn Leu Asp Ile 
             180                185                190
Thr Val Gly Ser Arg Gln Gln Ala Thr Gln Gly Trp Ile Asn Thr Tyr 
         195                200                205
Pro Leu Ser Ser Gly Met Ser Thr Ile Ser Lys Lys Ser Gly Met Ser 
     210                215                220
Lys Lys Thr Asn Arg Gly Ser Gln Leu His Lys Tyr Tyr Met Lys Arg 
 225                230                235                240
Arg Thr Leu Leu Leu Ser Leu Leu Ala Thr Glu Ile Glu Arg Leu Ile 
                 245                250                255
Thr Trp Tyr Asn Pro Leu Ser Ala Pro Glu Leu Glu Leu Asp Gln Ala 
             260                265                270
Gly Glu Asn Ser Val Ala Asn Trp Arg Ser Lys Tyr Ile Ser Leu Ser 
         275                280                285
Glu Lys Gln Trp Lys Asp Asn Val Asn Leu Ala Trp Ser Ile Ser Pro 
     290                295                300
Tyr Leu Ala Val Gln Leu Pro Ala Arg Phe Lys Asn Thr Glu Ala Ile 
 305                310                315                320
Gly Asn Glu Val Thr Arg Leu Val Arg Leu Asp Pro Gly Ala Val Ser 
                 325                330                335
Asp Val Pro Glu Ala Ile Lys Phe Leu Val Thr Trp His Thr Ile Asp 
             340                345                350
Ala Asp Ala Pro Glu Leu Ser His Val Leu Cys Trp Ala Pro Thr Asp 
         355                360                365
Pro Pro Thr Gly Leu Ser Tyr Phe Ser Ser Met Tyr Pro Pro His Pro 
     370                375                380
Leu Thr Ala Gln Tyr Gly Val Lys Val Leu Arg Ser Phe Pro Pro Asp 
 385                390                395                400
Ala Ile Leu Phe Tyr Ile Pro Gln Ile Val Gln Ala Leu Arg Tyr Asp 
                 405                410                415
Lys Met Gly Tyr Val Arg Glu Tyr Ile Leu Trp Ala Ala Ser Lys Ser 
             420                425                430
Gln Leu Leu Ala His Gln Phe Ile Trp Asn Met Lys Thr Asn Ile Tyr 
         435                440                445
Leu Asp Glu Glu Gly His Gln Lys Asp Pro Asp Ile Gly Asp Leu Leu 
     450                455                460
Asp Gln Leu Val Glu Glu Ile Thr Gly Ser Leu Ser Gly Pro Ala Lys 
 465                470                475                480
Asp Phe Tyr Gln Arg Glu Phe Asp Phe Phe Asn Lys Ile Thr Asn Val 
                 485                490                495
Ser Ala Ile Ile Lys Pro Tyr Pro Lys Gly Asp Glu Arg Lys Lys Ala 
             500                505                510
Cys Leu Ser Ala Leu Ser Glu Val Lys Val Gln Pro Gly Cys Tyr Leu 
         515                520                525
Pro Ser Asn Pro Glu Ala Ile Val Leu Asp Ile Asp Tyr Lys Ser Gly 
     530                535                540
Thr Pro Met Gln Ser Ala Ala Lys Ala Pro Tyr Leu Ala Lys Phe Lys 
 545                550                555                560
Val Lys Arg Cys Gly Val Ser Glu Leu Glu Lys Glu Gly Leu Arg Cys 
                 565                570                575
Arg Ser Asp Ser Glu Asp Glu Cys Ser Thr Gln Glu Ala Asp Gly Gln 
             580                585                590
Lys Ile Ser Trp Gln Ala Ala Ile Phe Lys Val Gly Asp Asp Cys Arg 
         595                600                605
Gln Asp Met Leu Ala Leu Gln Ile Ile Asp Leu Phe Lys Asn Ile Phe 
     610                615                620
Gln Leu Val Gly Leu Asp Leu Phe Val Phe Pro Tyr Arg Val Val Ala 
 625                630                635                640
Thr Ala Pro Gly Cys Gly Val Ile Glu Cys Ile Pro Asp Cys Thr Ser 
                 645                650                655
Arg Asp Gln Leu Gly Arg Gln Thr Asp Phe Gly Met Tyr Asp Tyr Phe 
             660                665                670
Thr Arg Gln Tyr Gly Asp Glu Ser Thr Leu Ala Phe Gln Gln Ala Arg 
         675                680                685
Tyr Asn Phe Ile Arg Ser Met Ala Ala Tyr Ser Leu Leu Leu Phe Leu 
     690                695                700
Leu Gln Ile Lys Asp Arg His Asn Gly Asn Ile Met Leu Asp Lys Lys 
 705                710                715                720
Gly His Ile Ile His Ile Asp Phe Gly Phe Met Phe Glu Ser Ser Pro 
                 725                730                735
Gly Gly Asn Leu Gly Trp Glu Pro Asp Ile Lys Leu Thr Asp Glu Met 
             740                745                750
Val Met Ile Met Gly Gly Lys Met Glu Ala Thr Pro Phe Lys Trp Phe 
         755                760                765
Met Glu Met Cys Val Arg Gly Tyr Leu Ala Val Arg Pro Tyr Met Asp 
     770                775                780
Ala Val Val Ser Leu Val Thr Leu Met Leu Asp Thr Gly Leu Pro Cys 
 785                790                795                800
Phe Arg Gly Gln Thr Ile Lys Leu Leu Lys His Arg Phe Ser Pro Asn 
                 805                810                815
Met Thr Glu Arg Glu Ala Ala Asn Phe Ile Met Lys Val Ile Gln Ser 
             820                825                830
Cys Phe Leu Ser Asn Arg Ser Arg Thr Tyr Asp Met Ile Gln Tyr Tyr 
         835                840                845
Gln Asn Asp Ile Pro Tyr 
     850



<210> 2191
<211> 6857
<212> DNA
<213> Rattus norvegicus
<308> D83538
<400> 2191

ttccagaat  gatagtggt  cggcccacc  ctgaaggtt  cagaatcga  agtggttcg  60
cccacctct  aaggttcca  aatcgatag  ggttcggcc  acctctgaa  gttccagaa  120
cgatagtgg  tcggcccac  tctgatggt  ccagcacct  ccgaggttt  tatttcaac  180
cagtgcttt  actggcccg  tccctggct  tgcagagac  tgcatccct  gagaaggtt  240
aaaattcgg  ccacctctg  aggttccag  atcgatagg  tctggttcc  gcacctccc  300
aggttttta  ttcaacaca  tgccttcac  ggcccgctc  ctggctgtg  agagacctg  360
atccttaga  aaggttcaa  agctgctgt  catgtgccc  gtagatttt  atggaatct  420
ccagctaga  gaaagacgg  gagatgcag  gattgctct  ggcattttt  tcattgagt  480
tgatcttca  cacaaagat  gtattgttc  ttatcttct  cgacttctc  ggggtcttc  540
aaaagtcta  tgggtagaa  aaagcacag  tcggaaagg  agaggtaac  tcccggttg  600
agaaagctt  agcttctgc  tggtgacct  gctgtctga  gtggcttgc  gggacccct  660
gcttaggga  gagatttta  aggcacttt  gcaggtttt  catgtcctt  tggggatgt  720
ccaggccct  gagattcaa  agaaagaat  cctttgcaa  tatgcaatc  catgcctga  780
agggatctc  aaatctttt  gacgttaca  caattcaga  gaatctctc  tctcaaagc  840
ttttcccaa  gtccctcct  attccctga  aatccccga  gagctagaa  gtgtccgaa  900
gcgttcctt  aatgacttc  gctccatcc  gcccagcaa  ctgctgact  tctgtcagg  960
gggcacact  aagaggaaa  ccagcagtg  gtccagcat  tctcaggtt  gcccagaac  1020
tggcatgcc  cctcccagc  cccctggag  atctgcttt  cactatttt  aagcctctt  1080
cctgcctga  ggaaccacc  tggagcccg  atactactt  tctaccatc  gctccagtt  1140
ttctgtctc  cccctgttc  atggtatca  ctataagga  ttctatatt  cactggaaa  1200
gcttcgaga  ctcttaaac  tggtaaaga  gattgttga  gagcctgtt  tcaagtcct  1260
agatgcagc  gtagccaga  tgatggagg  caatcccag  gctgaccta  actacacga  1320
cttcagtga  cccgtctac  tgaccatgt  caagatgct  cgagacact  tgtactata  1380
gaaagactt  cccacctcc  ttgtgaaag  gatccatga  tttgtgttg  agcagttca  1440
catgagcca  ggggaactc  aaaagattc  ccatgatgc  gacaggatc  acagtgaga  1500
gagcccact  aaactgcgc  gccaagcaa  tgctgcctg  gtagacctc  tggtgtggg  1560
tgtgaagga  gagcagggt  cagaaaacc  ttgcatcaa  ctgtctgaa  agctgcagt  1620
caagacatc  agcaaggtc  tcatcgccc  tttgccctt  ctgatctgc  gcctacagg  1680
tctgggccg  ctatgtgaa  ggttcccgg  ggtggtcca  tcagtgaca  catctttga  1740
agactttct  gtgattcca  ccccagtgc  ggtgaagct  tataagtac  acagtcagt  1800
ccacacagt  gctggcagt  atataaaaa  tagtgtcac  aatgagcat  ctgagtcaa  1860
tctgaatgt  ttgcccggc  agaagaacc  gccatccat  tatgagcag  tccgggaca  1920
cgccattga  aacatctgc  ggtgcctga  ggccggcct  accgtggac  ctgtgatcg  1980
ggaggcctt  ctggccagc  tctccaacc  gctctatat  tcccaggag  gcgataagg  2040
tgctcactt  attcctgac  ataccattc  tgccttggg  cacattgca  tggctctga  2100
ggatacccc  aaggtcatg  agccaattc  gcagcagaa  ttttgccag  ccccctcac  2160
cctcgatgt  ctcatcatc  accagctgg  ctgcctggt  atcactgga  atcaataca  2220
ttatcagga  gtgtggaat  tcttccaac  aatcagtgt  aaggccagt  cagttgtat  2280
ttcagccac  aaagactac  aagaccatg  ctacaggca  tgctccctc  cagtcatca  2340
tgccctggc  aacatcgca  ccaacattc  ggaggagca  cttgtggat  agctgttga  2400
gaacctgct  gaactgttt  tgcagctgg  gctggaggg  aagagagcc  gtgagaggg  2460
cagcgagaa  gggcccgcc  tgaaggctt  cagcagtgc  gggaatttg  gagtgctca  2520
tcctgtaat  gccgtgctc  cccgacgat  gccacccat  aaagaagct  aacctaggc  2580
acaaaagct  ttccgagac  tctggctct  ctctgtgct  atgggattc  ctgtggaag  2640
ctcagggct  tggccggaa  agtggtatg  aggagtctg  gaaatagca  ccaagtcac  2700
tctgcttac  tttcccagc  aagagcctc  tcgatcagt  ctccagtac  actcagcca  2760
gaaaaatga  acagtgacc  cggctgagc  gaatgagct  cgaagtacc  tcatcaact  2820
gctagatcc  cctcctgag  tgtctgccc  catcaacaa  ctggacttt  ccatgtcca  2880
ctatctctt  tctgtgtat  ggctggaat  catgagggt  ctgcgttct  cagatccag  2940
tcgcttcca  gtaatgttc  gctacttcg  ggataaagc  attcagaaa  acaaatctg  3000
gatgatgca  tgtgtcatc  ctgttgctg  caaagtatt  gatgccttc  tgaacatga  3060
ggcagaaaa  gccaagacc  aggagaatg  agaggagtt  gagcggcat  cccagtttc  3120
gctggtgaa  ttcaaccac  ttcacaaga  gatacgcag  gtggctgac  agtacctgt  3180
tggtctggt  gataagttt  cacacttgc  ctggagtgg  actgtgctg  agaccatgt  3240
ggacatcct  cagaccctg  cactatcac  aagtgctga  attcacaag  accaacctt  3300
ttatgacat  cctgacgcc  cctatcgga  cacggttcc  gacacgtat  aagcccggg  3360
gagcatcgt  aaagacttt  ctgcacgct  tgggatgat  ctgcaggaa  ccatgaagt  3420
ggcacccac  gtcactaag  cccacctgc  ggaatatct  aacaagcat  agaactggg  3480
gtcaggact  tcccagcac  cgggattgg  catggccac  gagagcatc  ttcactttg  3540
cggctacaa  aagcagaac  caactcttg  ggtaactca  ctcactgag  gcccggcct  3600
tgtgaagaa  gactactcc  acttcatgg  atccttgaa  ttgcgcaac  gctatgccg  3660
cgaggtgca  gggatgatt  ggttctcag  tgccacagg  cagatgtcc  acctgaaca  3720
aatgatggt  caggatctg  ttacagctc  ggaccacag  catcctcag  actataccc  3780
agccatgtt  aaattgacg  ccatgctca  tagcagcaa  gattgtgac  cacagctcc  3840
tcatcatct  tgttggggt  ccctccgga  gttcaacga  catggcatg  agactgcac  3900
agcctgctg  gagtggctg  tggctggca  gaatggagt  gaagtgccg  tcatgcggg  3960
gatggcagg  gcctggcac  tgacagtgg  gcagaagtt  ggcctcttc  ctgcagaaa  4020
aaaggaagc  gaccccctg  cagcgtcag  agcaagtca  ccacgaccc  gtccccctg  4080
agtgacacc  cactacatc  ggattgatt  cctggtgca  cggtttgag  ttgccaagt  4140
ctgtagctc  gaccaggtg  agatcttct  aagcctgct  cagcgctcc  tgtccctcc  4200
catcggtgg  gccaggggg  gcatgaaca  gcatgtggc  gccattgga  cacgtttca  4260
actgctgac  ctggggctg  ccctcctac  cgctgatgt  gttccaaat  caaccattc  4320
aaacgtgct  cgagagaag  tctactcaa  agcctttga  tatttcagt  gtccaccaa  4380
gttccctac  caaggagaa  agaggctgc  tgaagatat  agcatcatg  ttaagtttt  4440
gactgccat  ttctcagat  agaagtacc  gactgccag  caactcgtt  ccccagata  4500
ccaggacac  cgaagcaac  tggatataa  tgtgggctc  cgacaacag  ctacacagg  4560
atggatcaa  acatacccc  tctccagtg  catgtcaac  atctccaaa  aatcaggca  4620
gtctaagaa  accaaccga  gttcccagc  gcacaagta  tacatgaag  gtaggacgc  4680
gctgctgtc  ctgttggcc  ctgagatcg  gcgcctcat  acttggtac  acccgctgt  4740
agccccaga  ctagagctg  accaggcag  tgagaacag  gttgccaac  ggaggtcca  4800
gtatatcag  ctgagtgag  agcagtgga  ggacaacgt  aaccttgcc  ggaccatct  4860
tccatacct  gctgtgcag  tgccagcca  gttcaagaa  acagaagcc  ttggaaatg  4920
agtgacccg  ctcgttcgc  tggacccag  agctgttag  gatgtccct  aagctatca  4980
gttccttgt  acctggcac  ccatcgatg  tgatgctcc  gagcttagc  atgtgttat  5040
ctgggcacc  acggacccg  ccacgggcc  ctcctactt  tccagcatg  accccccac  5100
ccctctcac  gcacagtat  gggtgaaag  cctgcggtc  ttccctccg  atgccattc  5160
gttctacat  ccccagatt  tgcaggccc  cagatatga  aagatgggc  atgtgcgcg  5220
gtacattct  tgggctgca  ccaaatccc  gcttctggc  caccagttt  tttggaata  5280
gaaaactaa  atctacctt  atgaagaag  gcaccagaa  gaccctgac  ttggtgacc  5340
tctggagca  ttagtagaa  aaatcacag  gtctctatc  ggcccagcc  aagatttct  5400
tcaacggga  tttgatttc  ttaacaaga  caccaacgt  tcagctatc  tcaagccct  5460
ccctaaagg  gatgaaaga  agaaggctt  tctgtcagc  ctgtctgaa  tgaaggtgc  5520
gcctggctg  tacctgccc  gcaaccctg  agcaattgt  ctagacatt  actacaagt  5580
agggacacc  atgcagagt  ctgcaaaag  gccgtatct  gccaagttt  aggtgaagc  5640
atgcggagt  agtgaactt  aaaaagaag  tctgcagtg  cgctcagac  cagaggatg  5700
gtgccgcag  caagaggct  atggcaaga  gatctgctg  caagcagcc  tcttcaaag  5760
gggggatga  tgccgacag  acatgctag  cctgcagat  atcgacctt  tcaagaaca  5820
cttccagct  gttggcctg  acctcttcg  ttttcccta  cgggtagtg  ctactgccc  5880
tgggtgtgg  gtgattgag  gcattccag  ctgtacctc  cgagaccag  taggccgcc  5940
gactgactt  ggcatgtat  actacttta  acgccagta  ggggacgag  ctaccttgg  6000
cttccagca  gcacgctac  actttatca  aagcatggc  gcctacagc  tcctgctgt  6060
cctgctgca  atcaaggac  ggcacaacg  caacatcat  ctggacaag  agggacaca  6120
catccacat  gactttggc  tcatgtttg  aagctcacc  ggtggcaac  ttggctggg  6180
gccagacat  aagctgaca  acgagatgg  gatgattat  gggggcaag  tggaagcca  6240
acccttcaa  tggttcatg  agatgtgcg  ccgaggtta  ctggctgtg  gcccctata  6300
ggatgcagt  gtctccctg  ttacactca  gttggacac  ggcctgccc  gtttccgtg  6360
ccagacaat  aaacttttg  aacacaggt  cagcccgaa  atgacagag  gggaggctg  6420
aaattttat  atgaagatc  tccaaaact  tttcctcag  aacaggagc  ggacctacg  6480
catgatcca  tactaccag  atgatatcc  ctactgagg  gactgtacc  gaagccttg  6540
gtgtcacag  gcagcttgt  ctgtcacca  aagcctggg  gtggaggtg  caggcacat  6600
gaacttgga  gcacaggtg  gagtctttt  cacactgga  acattccct  tttgttcac  6660
catcttact  tgttggtac  tgaagtatt  tcctgtgta  acatgagaa  ttgacataa  6720
aaataagaa  cctaaaatg  gctacttct  tttgttagg  caccaagac  ttgtcctta  6780
tcaaaggta  cctttgaat  cctggtcct  ccaactcac  cctagctta  tcttgcttt  6840
atttggtcc  gaggatc  6857



<210> 2192
<211> 2041
<212> PRT
<213> Rattus norvegicus
<308> BAA19614
<400> 2192

Met Cys Pro Val Asp Phe His Gly Ile Phe Gln Leu Asp Glu Arg Arg 
  1               5                  10                  15
Arg Asp Ala Val Ile Ala Leu Gly Ile Phe Leu Ile Glu Ser Asp Leu 
             20                  25                  30
Gln His Lys Asp Cys Ile Val Pro Tyr Leu Leu Arg Leu Leu Arg Gly 
         35                  40                  45
Leu Pro Lys Val Tyr Trp Val Glu Glu Ser Thr Ala Arg Lys Gly Arg 
     50                  55                  60
Gly Asn Leu Pro Val Ala Glu Ser Phe Ser Phe Cys Leu Val Thr Leu 
 65                  70                  75                  80
Leu Ser Asp Val Ala Cys Arg Asp Pro Ser Leu Arg Asp Glu Ile Leu 
                 85                  90                  95
Glu Ala Leu Leu Gln Val Leu His Val Leu Leu Gly Met Cys Gln Ala 
             100                105                110
Leu Glu Ile Gln Glu Lys Glu Tyr Leu Cys Lys Tyr Ala Ile Pro Cys 
         115                120                125
Leu Ile Gly Ile Ser Lys Ser Phe Gly Arg Tyr Ser Asn Ser Glu Glu 
     130                135                140
Ser Leu Leu Ser Lys Leu Phe Pro Lys Val Pro Pro His Ser Leu Arg 
 145                150                155                160
Ile Pro Glu Glu Leu Glu Gly Val Arg Arg Arg Ser Phe Asn Asp Phe 
                 165                170                175
Arg Ser Ile Leu Pro Ser Asn Leu Leu Thr Val Cys Gln Glu Gly Thr 
             180                185                190
Leu Lys Arg Lys Thr Ser Ser Val Ser Ser Ile Ser Gln Val Ser Pro 
         195                200                205
Glu Arg Gly Met Pro Pro Pro Ser Ser Pro Gly Gly Ser Ala Phe His 
     210                215                220
Tyr Phe Glu Ala Ser Cys Leu Pro Asp Gly Thr Thr Leu Glu Pro Glu 
 225                230                235                240
Tyr Tyr Phe Ser Thr Ile Ser Ser Ser Phe Ser Val Ser Pro Leu Phe 
                 245                250                255
Asn Gly Ile Thr Tyr Lys Glu Phe Tyr Ile Pro Leu Glu Met Leu Arg 
             260                265                270
Glu Leu Leu Asn Leu Val Lys Lys Ile Val Glu Glu Pro Val Leu Lys 
         275                280                285
Ser Leu Asp Ala Ala Val Ala Arg Val Met Glu Ala Asn Pro Ser Ala 
     290                295                300
Asp Leu Tyr Tyr Thr Thr Phe Ser Asp Pro Val Tyr Leu Thr Met Phe 
 305                310                315                320
Lys Met Leu Arg Asp Thr Leu Tyr Tyr Met Lys Asp Leu Pro Thr Ser 
                 325                330                335
Phe Val Lys Glu Ile His Asp Phe Val Leu Glu Gln Phe Asn Met Ser 
             340                345                350
Gln Gly Glu Leu Gln Lys Ile Leu His Asp Ala Asp Arg Ile His Ser 
         355                360                365
Glu Met Ser Pro Leu Lys Leu Arg Cys Gln Ala Asn Ala Ala Cys Val 
     370                375                380
Asp Leu Met Val Trp Ala Val Lys Asp Glu Gln Gly Ala Glu Asn Leu 
 385                390                395                400
Cys Ile Lys Leu Ser Glu Lys Leu Gln Ser Lys Thr Ser Ser Lys Val 
                 405                410                415
Ile Ile Ala His Leu Pro Leu Leu Ile Cys Cys Leu Gln Gly Leu Gly 
             420                425                430
Arg Leu Cys Glu Arg Phe Pro Val Val Val His Ser Val Thr Pro Ser 
         435                440                445
Leu Arg Asp Phe Leu Val Ile Pro Ser Pro Val Leu Val Lys Leu Tyr 
     450                455                460
Lys Tyr His Ser Gln Tyr His Thr Val Ala Gly Ser Asp Ile Lys Ile 
 465                470                475                480
Ser Val Thr Asn Glu His Ser Glu Ser Thr Leu Asn Val Leu Pro Gly 
                 485                490                495
Lys Lys Asn Gln Pro Ser Met Tyr Glu Gln Leu Arg Asp Ile Ala Ile 
             500                505                510
Asp Asn Ile Cys Arg Cys Leu Lys Ala Gly Leu Thr Val Asp Pro Val 
         515                520                525
Ile Val Glu Ala Phe Leu Ala Ser Leu Ser Asn Arg Leu Tyr Ile Ser 
     530                535                540
Gln Glu Ser Asp Lys Asp Ala His Leu Ile Pro Asp His Thr Ile Arg 
 545                550                555                560
Ala Leu Gly His Ile Ala Val Ala Leu Arg Asp Thr Pro Lys Val Met 
                 565                570                575
Glu Pro Ile Leu Gln Gln Lys Phe Cys Gln Pro Pro Ser Pro Leu Asp 
             580                585                590
Val Leu Ile Ile Asp Gln Leu Gly Cys Leu Val Ile Thr Gly Asn Gln 
         595                600                605
Tyr Ile Tyr Gln Glu Val Trp Asn Leu Phe Gln Gln Ile Ser Val Lys 
     610                615                620
Ala Ser Ser Val Val Tyr Ser Ala Thr Lys Asp Tyr Lys Asp His Gly 
 625                630                635                640
Tyr Arg His Cys Ser Leu Ala Val Ile Asn Ala Leu Ala Asn Ile Ala 
                 645                650                655
Ala Asn Ile Gln Glu Glu His Leu Val Asp Glu Leu Leu Met Asn Leu 
             660                665                670
Leu Glu Leu Phe Val Gln Leu Gly Leu Glu Gly Lys Arg Ala Ser Glu 
         675                680                685
Arg Ala Ser Glu Lys Gly Pro Ala Leu Lys Ala Ser Ser Ser Ala Gly 
     690                695                700
Asn Leu Gly Val Leu Ile Pro Val Ile Ala Val Leu Thr Arg Arg Leu 
 705                710                715                720
Pro Pro Ile Lys Glu Ala Lys Pro Arg Leu Gln Lys Leu Phe Arg Asp 
                 725                730                735
Phe Trp Leu Tyr Ser Val Leu Met Gly Phe Ala Val Glu Gly Ser Gly 
             740                745                750
Leu Trp Pro Glu Glu Trp Tyr Glu Gly Val Cys Glu Ile Ala Thr Lys 
         755                760                765
Ser Pro Leu Leu Thr Phe Pro Ser Lys Glu Pro Leu Arg Ser Val Leu 
     770                775                780
Gln Tyr Asn Ser Ala Met Lys Asn Asp Thr Val Thr Pro Ala Glu Leu 
 785                790                795                800
Asn Glu Leu Arg Ser Thr Ile Ile Asn Leu Leu Asp Pro Pro Pro Glu 
                 805                810                815
Val Ser Ala Leu Ile Asn Lys Leu Asp Phe Ala Met Ser Thr Tyr Leu 
             820                825                830
Leu Ser Val Tyr Arg Leu Glu Tyr Met Arg Val Leu Arg Ser Thr Asp 
         835                840                845
Pro Asp Arg Phe Gln Val Met Phe Cys Tyr Phe Glu Asp Lys Ala Ile 
     850                855                860
Gln Lys Asp Lys Ser Gly Met Met Gln Cys Val Ile Ala Val Ala Asp 
 865                870                875                880
Lys Val Phe Asp Ala Phe Leu Asn Met Met Ala Glu Lys Ala Lys Thr 
                 885                890                895
Lys Glu Asn Glu Glu Glu Leu Glu Arg His Ala Gln Phe Leu Leu Val 
             900                905                910
Asn Phe Asn His Ile His Lys Arg Ile Arg Arg Val Ala Asp Lys Tyr 
         915                920                925
Leu Ser Gly Leu Val Asp Lys Phe Pro His Leu Leu Trp Ser Gly Thr 
     930                935                940
Val Leu Lys Thr Met Leu Asp Ile Leu Gln Thr Leu Ser Leu Ser Leu 
 945                950                955                960
Ser Ala Asp Ile His Lys Asp Gln Pro Tyr Tyr Asp Ile Pro Asp Ala 
                 965                970                975
Pro Tyr Arg Ile Thr Val Pro Asp Thr Tyr Glu Ala Arg Glu Ser Ile 
             980                985                990
Val Lys Asp Phe Ala Ala Arg Cys Gly Met Ile Leu Gln Glu Ala Met 
         995                1000                1005
Lys Trp Ala Pro Thr Val Thr Lys Ser His Leu Gln Glu Tyr Leu Asn 
     1010                1015                1020
Lys His Gln Asn Trp Val Ser Gly Leu Ser Gln His Thr Gly Leu Ala 
 1025                1030                1035                1040
Met Ala Thr Glu Ser Ile Leu His Phe Ala Gly Tyr Asn Lys Gln Asn 
                 1045                1050                1055
Thr Thr Leu Gly Val Thr Gln Leu Thr Glu Arg Pro Ala Cys Val Lys 
             1060                1065                1070
Lys Asp Tyr Ser Asn Phe Met Ala Ser Leu Asn Leu Arg Asn Arg Tyr 
         1075                1080                1085
Ala Gly Glu Val His Gly Met Ile Arg Phe Ser Gly Ala Thr Gly Gln 
     1090                1095                1100
Met Ser Asp Leu Asn Lys Met Met Val Gln Asp Leu Ile Thr Ala Leu 
 1105                1110                1115                1120
Asp His Ser His Pro Gln His Tyr Thr Gln Ala Met Phe Lys Leu Thr 
                 1125                1130                1135
Ala Met Leu Ile Ser Ser Lys Asp Cys Asp Pro Gln Leu Leu His His 
             1140                1145                1150
Leu Cys Trp Gly Pro Leu Arg Met Phe Asn Glu His Gly Met Glu Thr 
         1155                1160                1165
Ala Leu Ala Cys Trp Glu Trp Leu Leu Ala Gly Lys Asn Gly Val Glu 
     1170                1175                1180
Val Pro Phe Met Arg Glu Met Ala Gly Ala Trp His Met Thr Val Glu 
 1185                1190                1195                1200
Gln Lys Phe Gly Leu Phe Ser Ala Glu Thr Lys Glu Ala Asp Pro Leu 
                 1205                1210                1215
Ala Ala Ser Glu Ala Ser Gln Pro Arg Pro Cys Pro Pro Glu Val Thr 
             1220                1225                1230
Pro His Tyr Ile Trp Ile Asp Phe Leu Val Gln Arg Phe Glu Ile Ala 
         1235                1240                1245
Lys Tyr Cys Ser Ser Asp Gln Val Glu Ile Phe Ser Ser Leu Leu Gln 
     1250                1255                1260
Arg Ser Met Ser Leu His Ile Gly Gly Ala Arg Gly Ser Met Asn Arg 
 1265                1270                1275                1280
His Val Ala Ala Ile Gly Pro Arg Phe Lys Leu Leu Thr Leu Gly Leu 
                 1285                1290                1295
Ser Leu Leu His Ala Asp Val Val Pro Asn Ala Thr Ile Arg Asn Val 
             1300                1305                1310
Leu Arg Glu Lys Ile Tyr Ser Thr Ala Phe Asp Tyr Phe Ser Cys Pro 
         1315                1320                1325
Pro Lys Phe Pro Thr Gln Gly Glu Lys Arg Leu Arg Glu Asp Ile Ser 
     1330                1335                1340
Ile Met Ile Lys Phe Trp Thr Ala Met Phe Ser Asp Lys Lys Tyr Leu 
 1345                1350                1355                1360
Thr Ala Ser Gln Leu Val Pro Pro Asp Asn Gln Asp Thr Arg Ser Asn 
                 1365                1370                1375
Leu Asp Ile Thr Val Gly Ser Arg Gln Gln Ala Thr Gln Gly Trp Ile 
             1380                1385                1390
Asn Thr Tyr Pro Leu Ser Ser Gly Met Ser Thr Ile Ser Lys Lys Ser 
         1395                1400                1405
Gly Met Ser Lys Lys Thr Asn Arg Gly Ser Gln Leu His Lys Tyr Tyr 
     1410                1415                1420
Met Lys Arg Arg Thr Leu Leu Leu Ser Leu Leu Ala Thr Glu Ile Glu 
 1425                1430                1435                1440
Arg Leu Ile Thr Trp Tyr Asn Pro Leu Ser Ala Pro Glu Leu Glu Leu 
                 1445                1450                1455
Asp Gln Ala Gly Glu Asn Ser Val Ala Asn Trp Arg Ser Lys Tyr Ile 
             1460                1465                1470
Ser Leu Ser Glu Lys Gln Trp Lys Asp Asn Val Asn Leu Ala Trp Thr 
         1475                1480                1485
Ile Ser Pro Tyr Leu Ala Val Gln Leu Pro Ala Arg Phe Lys Asn Thr 
     1490                1495                1500
Glu Ala Ile Gly Asn Glu Val Thr Arg Leu Val Arg Leu Asp Pro Gly 
 1505                1510                1515                1520
Ala Val Ser Asp Val Pro Glu Ala Ile Lys Phe Leu Val Thr Trp His 
                 1525                1530                1535
Thr Ile Asp Ala Asp Ala Pro Glu Leu Ser His Val Leu Cys Trp Ala 
             1540                1545                1550
Pro Thr Asp Pro Pro Thr Gly Leu Ser Tyr Phe Ser Ser Met Tyr Pro 
         1555                1560                1565
Pro His Pro Leu Thr Ala Gln Tyr Gly Val Lys Val Leu Arg Ser Phe 
     1570                1575                1580
Pro Pro Asp Ala Ile Leu Phe Tyr Ile Pro Gln Ile Val Gln Ala Leu 
 1585                1590                1595                1600
Arg Tyr Asp Lys Met Gly Tyr Val Arg Glu Tyr Ile Leu Trp Ala Ala 
                 1605                1610                1615
Ala Lys Ser Gln Leu Leu Ala His Gln Phe Ile Trp Asn Met Lys Thr 
             1620                1625                1630
Asn Ile Tyr Leu Asp Glu Glu Gly His Gln Lys Asp Pro Asp Ile Gly 
         1635                1640                1645
Asp Leu Leu Glu Gln Leu Val Glu Glu Ile Thr Gly Ser Leu Ser Gly 
     1650                1655                1660
Pro Ala Lys Asp Phe Tyr Gln Arg Glu Phe Asp Phe Phe Asn Lys Ile 
 1665                1670                1675                1680
Thr Asn Val Ser Ala Ile Ile Lys Pro Tyr Pro Lys Gly Asp Glu Arg 
                 1685                1690                1695
Lys Lys Ala Cys Leu Ser Ala Leu Ser Glu Val Lys Val Gln Pro Gly 
             1700                1705                1710
Cys Tyr Leu Pro Ser Asn Pro Glu Ala Ile Val Leu Asp Ile Asp Tyr 
         1715                1720                1725
Lys Ser Gly Thr Pro Met Gln Ser Ala Ala Lys Ala Pro Tyr Leu Ala 
     1730                1735                1740
Lys Phe Lys Val Lys Arg Cys Gly Val Ser Glu Leu Glu Lys Glu Gly 
 1745                1750                1755                1760
Leu Gln Cys Arg Ser Asp Thr Glu Asp Glu Cys Arg Arg Gln Glu Ala 
                 1765                1770                1775
Asp Gly Lys Lys Ile Cys Trp Gln Ala Ala Ile Phe Lys Val Gly Asp 
             1780                1785                1790
Asp Cys Arg Gln Asp Met Leu Ala Leu Gln Ile Ile Asp Leu Phe Lys 
         1795                1800                1805
Asn Ile Phe Gln Leu Val Gly Leu Asp Leu Phe Val Phe Pro Tyr Arg 
     1810                1815                1820
Val Val Ala Thr Ala Pro Gly Cys Gly Val Ile Glu Cys Ile Pro Asp 
 1825                1830                1835                1840
Cys Thr Ser Arg Asp Gln Leu Gly Arg Gln Thr Asp Phe Gly Met Tyr 
                 1845                1850                1855
Asp Tyr Phe Thr Arg Gln Tyr Gly Asp Glu Ser Thr Leu Ala Phe Gln 
             1860                1865                1870
Gln Ala Arg Tyr Asn Phe Ile Arg Ser Met Ala Ala Tyr Ser Leu Leu 
         1875                1880                1885
Leu Phe Leu Leu Gln Ile Lys Asp Arg His Asn Gly Asn Ile Met Leu 
     1890                1895                1900
Asp Lys Lys Gly His Ile Ile His Ile Asp Phe Gly Phe Met Phe Glu 
 1905                1910                1915                1920
Ser Ser Pro Gly Gly Asn Leu Gly Trp Glu Pro Asp Ile Lys Leu Thr 
                 1925                1930                1935
Asp Glu Met Val Met Ile Met Gly Gly Lys Met Glu Ala Thr Pro Phe 
             1940                1945                1950
Lys Trp Phe Met Glu Met Cys Val Arg Gly Tyr Leu Ala Val Arg Pro 
         1955                1960                1965
Tyr Met Asp Ala Val Val Ser Leu Val Thr Leu Met Leu Asp Thr Gly 
     1970                1975                1980
Leu Pro Cys Phe Arg Gly Gln Thr Ile Lys Leu Leu Lys His Arg Phe 
 1985                1990                1995                2000
Ser Pro Asn Met Thr Glu Arg Glu Ala Ala Asn Phe Ile Met Lys Ile 
                 2005                2010                2015
Ile Gln Asn Cys Phe Leu Ser Asn Arg Ser Arg Thr Tyr Asp Met Ile 
             2020                2025                2030
Gln Tyr Tyr Gln Asn Asp Ile Pro Tyr 
         2035                2040



<210> 2193
<211> 1787
<212> DNA
<213> Homo sapiens
<308> AK024034
<400> 2193

aaaaaatta  ctgggcatg  tggtgggca  ctgtagtcc  agctactcg  gaggctgag  60
caggagaat  tcttgaacc  aggaggcag  ggttgcagt  agccaagat  atgccactg  120
actccagcc  ggcgacaga  cgagactcc  tttaaaaaa  aaaacacca  ggcatctgt  180
agccacttt  ggagtcaaa  gaatgtaga  ctgggctgg  ctccttaga  gaaagttaa  240
ttctgagtg  gggaggaag  gcctgcacc  ccacatcca  acagcccgt  actcctgct  300
ccgaagact  acttgctga  tcgggctct  cctccatag  gggggcaca  agccaggga  360
agtgcccac  ggcccaggg  tcctgggtg  gggaccagg  agaatgccc  caggcccca  420
ggccttttt  agcccaggg  gctctctgc  caggcctgc  acaacttca  ccgaagcat  480
gccgcctac  gcctcctgc  gttcctgct  cagatcaag  acagacaca  cggcaacat  540
atgctggac  agaagggcc  tatcatcca  atcggtcag  cagccacag  gccaccctc  600
tctcccttc  ccccggcac  caggggtgg  tagggatcc  caccccaca  agaggagaa  660
gcccaggac  accctgcca  gagtgtcag  gtccagctc  gaggtccga  ctgtcggcc  720
ccaagctgt  ctgctgtag  gggtgcctg  ccccggccc  agggagctg  ggcgagagc  780
gccattgct  tgagtcaga  gctggagct  ggcggagtg  ggctcgtcc  ggttcagtg  840
cccagcttg  ctccttcct  cacttcctc  cttctcttt  tctgcctgc  gccccacca  900
ccaccccat  actgtctcc  agaaaacac  acctgcctt  tgggggtgg  gggggtgct  960
ctgttgcag  gtccttttc  actcctcaa  acagaccac  cgtccttgc  cgccctggc  1020
cctacccag  cacaggcag  tctttggtg  tttgcagac  ttggcttca  gtttgaaag  1080
tcgccgggc  gcaatctcg  ctgggaacc  gacatcaag  tgacggatg  gatggtgat  1140
atcatgggg  gcaagatgg  ggccacacc  ttcaagtgg  tcatggaga  gtgtgtcca  1200
gctacctgg  tgtgcggcc  tacatggat  tggtcgtct  cctggtcac  atcatgttg  1260
acacgggcc  gccctgttt  cgcggccag  caatcaagt  cttgaagca  aggtttagc  1320
ccaacatga  tgagcgcga  gctgcaaat  tcatcatga  ggtcatcca  agctgcttc  1380
tcagcaaca  gagccggac  tacaacatg  tccagtact  tcagaatga  atcccctac  1440
gaggagggg  ccttcgagg  cctctgccc  atgtgccct  gaagctgcc  cacaatcat  1500
gagccctgc  acctacccg  cctgccgcc  catgcagtg  aggagaggc  tgtggcccg  1560
agagcctgg  agcgcctcc  ggggcagca  gtgggtggc  caggcttag  aacgccgtg  1620
actgcagcg  caatcagtg  atggtgctg  ctatgcaca  gtgtgagtc  tctgtttgc  1680
ctggacata  tccctacct  ttttatttc  taggtacat  aagtattgt  tataaaaaa  1740
gagataaga  ttaaccaac  tcaacaaaa  aaaaaccca  aatagtg  1787



<210> 2194
<211> 854
<212> PRT
<213> Homo sapiens
<308> P42356
<400> 2194

Met Arg Glu Met Ala Gly Ala Trp His Met Thr Val Glu Gln Lys Phe 
  1               5                  10                  15
Gly Leu Phe Ser Ala Glu Ile Lys Glu Ala Asp Pro Leu Ala Ala Ser 
             20                  25                  30
Glu Ala Ser Gln Pro Lys Pro Cys Pro Pro Glu Val Thr Pro His Tyr 
         35                  40                  45
Ile Trp Ile Asp Phe Leu Val Gln Arg Phe Glu Ile Ala Lys Tyr Cys 
     50                  55                  60
Ser Ser Asp Gln Val Glu Ile Phe Ser Ser Leu Leu Gln Arg Ser Met 
 65                  70                  75                  80
Ser Leu Asn Ile Gly Gly Ala Lys Gly Ser Met Asn Arg His Val Ala 
                 85                  90                  95
Ala Ile Gly Pro Arg Phe Lys Leu Leu Thr Leu Gly Leu Ser Leu Leu 
             100                105                110
His Ala Asp Val Val Pro Asn Ala Thr Ile Arg Asn Val Leu Arg Glu 
         115                120                125
Lys Ile Tyr Ser Thr Ala Phe Asp Tyr Phe Ser Cys Pro Pro Lys Phe 
     130                135                140
Pro Thr Gln Gly Glu Lys Arg Leu Arg Glu Asp Ile Ser Ile Met Ile 
 145                150                155                160
Lys Phe Trp Thr Ala Met Phe Ser Asp Lys Lys Tyr Leu Thr Ala Ser 
                 165                170                175
Gln Leu Val Pro Pro Asp Asn Gln Asp Thr Arg Ser Asn Leu Asp Ile 
             180                185                190
Thr Val Gly Ser Arg Gln Gln Ala Thr Gln Gly Trp Ile Asn Thr Tyr 
         195                200                205
Pro Leu Ser Ser Gly Met Ser Thr Ile Ser Lys Lys Ser Gly Met Ser 
     210                215                220
Lys Lys Thr Asn Arg Gly Ser Gln Leu His Lys Tyr Tyr Met Lys Arg 
 225                230                235                240
Arg Thr Leu Leu Leu Ser Leu Leu Ala Thr Glu Ile Glu Arg Leu Ile 
                 245                250                255
Thr Trp Tyr Asn Pro Leu Ser Ala Pro Glu Leu Glu Leu Asp Gln Ala 
             260                265                270
Gly Glu Asn Ser Val Ala Asn Trp Arg Ser Lys Tyr Ile Ser Leu Ser 
         275                280                285
Glu Lys Gln Trp Lys Asp Asn Val Asn Leu Ala Trp Ser Ile Ser Pro 
     290                295                300
Tyr Leu Ala Val Gln Leu Pro Ala Arg Phe Lys Asn Thr Glu Ala Ile 
 305                310                315                320
Gly Asn Glu Val Thr Arg Leu Val Arg Leu Asp Pro Gly Ala Val Ser 
                 325                330                335
Asp Val Pro Glu Ala Ile Lys Phe Leu Val Thr Trp His Thr Ile Asp 
             340                345                350
Ala Asp Ala Pro Glu Leu Ser His Val Leu Cys Trp Ala Pro Thr Asp 
         355                360                365
Pro Pro Thr Gly Leu Ser Tyr Phe Ser Ser Met Tyr Pro Pro His Pro 
     370                375                380
Leu Thr Ala Gln Tyr Gly Val Lys Val Leu Arg Ser Phe Pro Pro Asp 
 385                390                395                400
Ala Ile Leu Phe Tyr Ile Pro Gln Ile Val Gln Ala Leu Arg Tyr Asp 
                 405                410                415
Lys Met Gly Tyr Val Arg Glu Tyr Ile Leu Trp Ala Ala Ser Lys Ser 
             420                425                430
Gln Leu Leu Ala His Gln Phe Ile Trp Asn Met Lys Thr Asn Ile Tyr 
         435                440                445
Leu Asp Glu Glu Gly His Gln Lys Asp Pro Asp Ile Gly Asp Leu Leu 
     450                455                460
Asp Gln Leu Val Glu Glu Ile Thr Gly Ser Leu Ser Gly Pro Ala Lys 
 465                470                475                480
Asp Phe Tyr Gln Arg Glu Phe Asp Phe Phe Asn Lys Ile Thr Asn Val 
                 485                490                495
Ser Ala Ile Ile Lys Pro Tyr Pro Lys Gly Asp Glu Arg Lys Lys Ala 
             500                505                510
Cys Leu Ser Ala Leu Ser Glu Val Lys Val Gln Pro Gly Cys Tyr Leu 
         515                520                525
Pro Ser Asn Pro Glu Ala Ile Val Leu Asp Ile Asp Tyr Lys Ser Gly 
     530                535                540
Thr Pro Met Gln Ser Ala Ala Lys Ala Pro Tyr Leu Ala Lys Phe Lys 
 545                550                555                560
Val Lys Arg Cys Gly Val Ser Glu Leu Glu Lys Glu Gly Leu Arg Cys 
                 565                570                575
Arg Ser Asp Ser Glu Asp Glu Cys Ser Thr Gln Glu Ala Asp Gly Gln 
             580                585                590
Lys Ile Ser Trp Gln Ala Ala Ile Phe Lys Val Gly Asp Asp Cys Arg 
         595                600                605
Gln Asp Met Leu Ala Leu Gln Ile Ile Asp Leu Phe Lys Asn Ile Phe 
     610                615                620
Gln Leu Val Gly Leu Asp Leu Phe Val Phe Pro Tyr Arg Val Val Ala 
 625                630                635                640
Thr Ala Pro Gly Cys Gly Val Ile Glu Cys Ile Pro Asp Cys Thr Ser 
                 645                650                655
Arg Asp Gln Leu Gly Arg Gln Thr Asp Phe Gly Met Tyr Asp Tyr Phe 
             660                665                670
Thr Arg Gln Tyr Gly Asp Glu Ser Thr Leu Ala Phe Gln Gln Ala Arg 
         675                680                685
Tyr Asn Phe Ile Arg Ser Met Ala Ala Tyr Ser Leu Leu Leu Phe Leu 
     690                695                700
Leu Gln Ile Lys Asp Arg His Asn Gly Asn Ile Met Leu Asp Lys Lys 
 705                710                715                720
Gly His Ile Ile His Ile Asp Phe Gly Phe Met Phe Glu Ser Ser Pro 
                 725                730                735
Gly Gly Asn Leu Gly Trp Glu Pro Asp Ile Lys Leu Thr Asp Glu Met 
             740                745                750
Val Met Ile Met Gly Gly Lys Met Glu Ala Thr Pro Phe Lys Trp Phe 
         755                760                765
Met Glu Met Cys Val Arg Gly Tyr Leu Ala Val Arg Pro Tyr Met Asp 
     770                775                780
Ala Val Val Ser Leu Val Thr Leu Met Leu Asp Thr Gly Leu Pro Cys 
 785                790                795                800
Phe Arg Gly Gln Thr Ile Lys Leu Leu Lys His Arg Phe Ser Pro Asn 
                 805                810                815
Met Thr Glu Arg Glu Ala Ala Asn Phe Ile Met Lys Val Ile Gln Ser 
             820                825                830
Cys Phe Leu Ser Asn Arg Ser Arg Thr Tyr Asp Met Ile Gln Tyr Tyr 
         835                840                845
Gln Asn Asp Ile Pro Tyr 
     850



<210> 2195
<211> 6857
<212> DNA
<213> Rattus norvegicus
<308> D83538
<400> 2195

ttccagaat  gatagtggt  cggcccacc  ctgaaggtt  cagaatcga  agtggttcg  60
cccacctct  aaggttcca  aatcgatag  ggttcggcc  acctctgaa  gttccagaa  120
cgatagtgg  tcggcccac  tctgatggt  ccagcacct  ccgaggttt  tatttcaac  180
cagtgcttt  actggcccg  tccctggct  tgcagagac  tgcatccct  gagaaggtt  240
aaaattcgg  ccacctctg  aggttccag  atcgatagg  tctggttcc  gcacctccc  300
aggttttta  ttcaacaca  tgccttcac  ggcccgctc  ctggctgtg  agagacctg  360
atccttaga  aaggttcaa  agctgctgt  catgtgccc  gtagatttt  atggaatct  420
ccagctaga  gaaagacgg  gagatgcag  gattgctct  ggcattttt  tcattgagt  480
tgatcttca  cacaaagat  gtattgttc  ttatcttct  cgacttctc  ggggtcttc  540
aaaagtcta  tgggtagaa  aaagcacag  tcggaaagg  agaggtaac  tcccggttg  600
agaaagctt  agcttctgc  tggtgacct  gctgtctga  gtggcttgc  gggacccct  660
gcttaggga  gagatttta  aggcacttt  gcaggtttt  catgtcctt  tggggatgt  720
ccaggccct  gagattcaa  agaaagaat  cctttgcaa  tatgcaatc  catgcctga  780
agggatctc  aaatctttt  gacgttaca  caattcaga  gaatctctc  tctcaaagc  840
ttttcccaa  gtccctcct  attccctga  aatccccga  gagctagaa  gtgtccgaa  900
gcgttcctt  aatgacttc  gctccatcc  gcccagcaa  ctgctgact  tctgtcagg  960
gggcacact  aagaggaaa  ccagcagtg  gtccagcat  tctcaggtt  gcccagaac  1020
tggcatgcc  cctcccagc  cccctggag  atctgcttt  cactatttt  aagcctctt  1080
cctgcctga  ggaaccacc  tggagcccg  atactactt  tctaccatc  gctccagtt  1140
ttctgtctc  cccctgttc  atggtatca  ctataagga  ttctatatt  cactggaaa  1200
gcttcgaga  ctcttaaac  tggtaaaga  gattgttga  gagcctgtt  tcaagtcct  1260
agatgcagc  gtagccaga  tgatggagg  caatcccag  gctgaccta  actacacga  1320
cttcagtga  cccgtctac  tgaccatgt  caagatgct  cgagacact  tgtactata  1380
gaaagactt  cccacctcc  ttgtgaaag  gatccatga  tttgtgttg  agcagttca  1440
catgagcca  ggggaactc  aaaagattc  ccatgatgc  gacaggatc  acagtgaga  1500
gagcccact  aaactgcgc  gccaagcaa  tgctgcctg  gtagacctc  tggtgtggg  1560
tgtgaagga  gagcagggt  cagaaaacc  ttgcatcaa  ctgtctgaa  agctgcagt  1620
caagacatc  agcaaggtc  tcatcgccc  tttgccctt  ctgatctgc  gcctacagg  1680
tctgggccg  ctatgtgaa  ggttcccgg  ggtggtcca  tcagtgaca  catctttga  1740
agactttct  gtgattcca  ccccagtgc  ggtgaagct  tataagtac  acagtcagt  1800
ccacacagt  gctggcagt  atataaaaa  tagtgtcac  aatgagcat  ctgagtcaa  1860
tctgaatgt  ttgcccggc  agaagaacc  gccatccat  tatgagcag  tccgggaca  1920
cgccattga  aacatctgc  ggtgcctga  ggccggcct  accgtggac  ctgtgatcg  1980
ggaggcctt  ctggccagc  tctccaacc  gctctatat  tcccaggag  gcgataagg  2040
tgctcactt  attcctgac  ataccattc  tgccttggg  cacattgca  tggctctga  2100
ggatacccc  aaggtcatg  agccaattc  gcagcagaa  ttttgccag  ccccctcac  2160
cctcgatgt  ctcatcatc  accagctgg  ctgcctggt  atcactgga  atcaataca  2220
ttatcagga  gtgtggaat  tcttccaac  aatcagtgt  aaggccagt  cagttgtat  2280
ttcagccac  aaagactac  aagaccatg  ctacaggca  tgctccctc  cagtcatca  2340
tgccctggc  aacatcgca  ccaacattc  ggaggagca  cttgtggat  agctgttga  2400
gaacctgct  gaactgttt  tgcagctgg  gctggaggg  aagagagcc  gtgagaggg  2460
cagcgagaa  gggcccgcc  tgaaggctt  cagcagtgc  gggaatttg  gagtgctca  2520
tcctgtaat  gccgtgctc  cccgacgat  gccacccat  aaagaagct  aacctaggc  2580
acaaaagct  ttccgagac  tctggctct  ctctgtgct  atgggattc  ctgtggaag  2640
ctcagggct  tggccggaa  agtggtatg  aggagtctg  gaaatagca  ccaagtcac  2700
tctgcttac  tttcccagc  aagagcctc  tcgatcagt  ctccagtac  actcagcca  2760
gaaaaatga  acagtgacc  cggctgagc  gaatgagct  cgaagtacc  tcatcaact  2820
gctagatcc  cctcctgag  tgtctgccc  catcaacaa  ctggacttt  ccatgtcca  2880
ctatctctt  tctgtgtat  ggctggaat  catgagggt  ctgcgttct  cagatccag  2940
tcgcttcca  gtaatgttc  gctacttcg  ggataaagc  attcagaaa  acaaatctg  3000
gatgatgca  tgtgtcatc  ctgttgctg  caaagtatt  gatgccttc  tgaacatga  3060
ggcagaaaa  gccaagacc  aggagaatg  agaggagtt  gagcggcat  cccagtttc  3120
gctggtgaa  ttcaaccac  ttcacaaga  gatacgcag  gtggctgac  agtacctgt  3180
tggtctggt  gataagttt  cacacttgc  ctggagtgg  actgtgctg  agaccatgt  3240
ggacatcct  cagaccctg  cactatcac  aagtgctga  attcacaag  accaacctt  3300
ttatgacat  cctgacgcc  cctatcgga  cacggttcc  gacacgtat  aagcccggg  3360
gagcatcgt  aaagacttt  ctgcacgct  tgggatgat  ctgcaggaa  ccatgaagt  3420
ggcacccac  gtcactaag  cccacctgc  ggaatatct  aacaagcat  agaactggg  3480
gtcaggact  tcccagcac  cgggattgg  catggccac  gagagcatc  ttcactttg  3540
cggctacaa  aagcagaac  caactcttg  ggtaactca  ctcactgag  gcccggcct  3600
tgtgaagaa  gactactcc  acttcatgg  atccttgaa  ttgcgcaac  gctatgccg  3660
cgaggtgca  gggatgatt  ggttctcag  tgccacagg  cagatgtcc  acctgaaca  3720
aatgatggt  caggatctg  ttacagctc  ggaccacag  catcctcag  actataccc  3780
agccatgtt  aaattgacg  ccatgctca  tagcagcaa  gattgtgac  cacagctcc  3840
tcatcatct  tgttggggt  ccctccgga  gttcaacga  catggcatg  agactgcac  3900
agcctgctg  gagtggctg  tggctggca  gaatggagt  gaagtgccg  tcatgcggg  3960
gatggcagg  gcctggcac  tgacagtgg  gcagaagtt  ggcctcttc  ctgcagaaa  4020
aaaggaagc  gaccccctg  cagcgtcag  agcaagtca  ccacgaccc  gtccccctg  4080
agtgacacc  cactacatc  ggattgatt  cctggtgca  cggtttgag  ttgccaagt  4140
ctgtagctc  gaccaggtg  agatcttct  aagcctgct  cagcgctcc  tgtccctcc  4200
catcggtgg  gccaggggg  gcatgaaca  gcatgtggc  gccattgga  cacgtttca  4260
actgctgac  ctggggctg  ccctcctac  cgctgatgt  gttccaaat  caaccattc  4320
aaacgtgct  cgagagaag  tctactcaa  agcctttga  tatttcagt  gtccaccaa  4380
gttccctac  caaggagaa  agaggctgc  tgaagatat  agcatcatg  ttaagtttt  4440
gactgccat  ttctcagat  agaagtacc  gactgccag  caactcgtt  ccccagata  4500
ccaggacac  cgaagcaac  tggatataa  tgtgggctc  cgacaacag  ctacacagg  4560
atggatcaa  acatacccc  tctccagtg  catgtcaac  atctccaaa  aatcaggca  4620
gtctaagaa  accaaccga  gttcccagc  gcacaagta  tacatgaag  gtaggacgc  4680
gctgctgtc  ctgttggcc  ctgagatcg  gcgcctcat  acttggtac  acccgctgt  4740
agccccaga  ctagagctg  accaggcag  tgagaacag  gttgccaac  ggaggtcca  4800
gtatatcag  ctgagtgag  agcagtgga  ggacaacgt  aaccttgcc  ggaccatct  4860
tccatacct  gctgtgcag  tgccagcca  gttcaagaa  acagaagcc  ttggaaatg  4920
agtgacccg  ctcgttcgc  tggacccag  agctgttag  gatgtccct  aagctatca  4980
gttccttgt  acctggcac  ccatcgatg  tgatgctcc  gagcttagc  atgtgttat  5040
ctgggcacc  acggacccg  ccacgggcc  ctcctactt  tccagcatg  accccccac  5100
ccctctcac  gcacagtat  gggtgaaag  cctgcggtc  ttccctccg  atgccattc  5160
gttctacat  ccccagatt  tgcaggccc  cagatatga  aagatgggc  atgtgcgcg  5220
gtacattct  tgggctgca  ccaaatccc  gcttctggc  caccagttt  tttggaata  5280
gaaaactaa  atctacctt  atgaagaag  gcaccagaa  gaccctgac  ttggtgacc  5340
tctggagca  ttagtagaa  aaatcacag  gtctctatc  ggcccagcc  aagatttct  5400
tcaacggga  tttgatttc  ttaacaaga  caccaacgt  tcagctatc  tcaagccct  5460
ccctaaagg  gatgaaaga  agaaggctt  tctgtcagc  ctgtctgaa  tgaaggtgc  5520
gcctggctg  tacctgccc  gcaaccctg  agcaattgt  ctagacatt  actacaagt  5580
agggacacc  atgcagagt  ctgcaaaag  gccgtatct  gccaagttt  aggtgaagc  5640
atgcggagt  agtgaactt  aaaaagaag  tctgcagtg  cgctcagac  cagaggatg  5700
gtgccgcag  caagaggct  atggcaaga  gatctgctg  caagcagcc  tcttcaaag  5760
gggggatga  tgccgacag  acatgctag  cctgcagat  atcgacctt  tcaagaaca  5820
cttccagct  gttggcctg  acctcttcg  ttttcccta  cgggtagtg  ctactgccc  5880
tgggtgtgg  gtgattgag  gcattccag  ctgtacctc  cgagaccag  taggccgcc  5940
gactgactt  ggcatgtat  actacttta  acgccagta  ggggacgag  ctaccttgg  6000
cttccagca  gcacgctac  actttatca  aagcatggc  gcctacagc  tcctgctgt  6060
cctgctgca  atcaaggac  ggcacaacg  caacatcat  ctggacaag  agggacaca  6120
catccacat  gactttggc  tcatgtttg  aagctcacc  ggtggcaac  ttggctggg  6180
gccagacat  aagctgaca  acgagatgg  gatgattat  gggggcaag  tggaagcca  6240
acccttcaa  tggttcatg  agatgtgcg  ccgaggtta  ctggctgtg  gcccctata  6300
ggatgcagt  gtctccctg  ttacactca  gttggacac  ggcctgccc  gtttccgtg  6360
ccagacaat  aaacttttg  aacacaggt  cagcccgaa  atgacagag  gggaggctg  6420
aaattttat  atgaagatc  tccaaaact  tttcctcag  aacaggagc  ggacctacg  6480
catgatcca  tactaccag  atgatatcc  ctactgagg  gactgtacc  gaagccttg  6540
gtgtcacag  gcagcttgt  ctgtcacca  aagcctggg  gtggaggtg  caggcacat  6600
gaacttgga  gcacaggtg  gagtctttt  cacactgga  acattccct  tttgttcac  6660
catcttact  tgttggtac  tgaagtatt  tcctgtgta  acatgagaa  ttgacataa  6720
aaataagaa  cctaaaatg  gctacttct  tttgttagg  caccaagac  ttgtcctta  6780
tcaaaggta  cctttgaat  cctggtcct  ccaactcac  cctagctta  tcttgcttt  6840
atttggtcc  gaggatc  6857



<210> 2196
<211> 2041
<212> PRT
<213> Rattus norvegicus
<308> BAA19614
<400> 2196

Met Cys Pro Val Asp Phe His Gly Ile Phe Gln Leu Asp Glu Arg Arg 
  1               5                  10                  15
Arg Asp Ala Val Ile Ala Leu Gly Ile Phe Leu Ile Glu Ser Asp Leu 
             20                  25                  30
Gln His Lys Asp Cys Ile Val Pro Tyr Leu Leu Arg Leu Leu Arg Gly 
         35                  40                  45
Leu Pro Lys Val Tyr Trp Val Glu Glu Ser Thr Ala Arg Lys Gly Arg 
     50                  55                  60
Gly Asn Leu Pro Val Ala Glu Ser Phe Ser Phe Cys Leu Val Thr Leu 
 65                  70                  75                  80
Leu Ser Asp Val Ala Cys Arg Asp Pro Ser Leu Arg Asp Glu Ile Leu 
                 85                  90                  95
Glu Ala Leu Leu Gln Val Leu His Val Leu Leu Gly Met Cys Gln Ala 
             100                105                110
Leu Glu Ile Gln Glu Lys Glu Tyr Leu Cys Lys Tyr Ala Ile Pro Cys 
         115                120                125
Leu Ile Gly Ile Ser Lys Ser Phe Gly Arg Tyr Ser Asn Ser Glu Glu 
     130                135                140
Ser Leu Leu Ser Lys Leu Phe Pro Lys Val Pro Pro His Ser Leu Arg 
 145                150                155                160
Ile Pro Glu Glu Leu Glu Gly Val Arg Arg Arg Ser Phe Asn Asp Phe 
                 165                170                175
Arg Ser Ile Leu Pro Ser Asn Leu Leu Thr Val Cys Gln Glu Gly Thr 
             180                185                190
Leu Lys Arg Lys Thr Ser Ser Val Ser Ser Ile Ser Gln Val Ser Pro 
         195                200                205
Glu Arg Gly Met Pro Pro Pro Ser Ser Pro Gly Gly Ser Ala Phe His 
     210                215                220
Tyr Phe Glu Ala Ser Cys Leu Pro Asp Gly Thr Thr Leu Glu Pro Glu 
 225                230                235                240
Tyr Tyr Phe Ser Thr Ile Ser Ser Ser Phe Ser Val Ser Pro Leu Phe 
                 245                250                255
Asn Gly Ile Thr Tyr Lys Glu Phe Tyr Ile Pro Leu Glu Met Leu Arg 
             260                265                270
Glu Leu Leu Asn Leu Val Lys Lys Ile Val Glu Glu Pro Val Leu Lys 
         275                280                285
Ser Leu Asp Ala Ala Val Ala Arg Val Met Glu Ala Asn Pro Ser Ala 
     290                295                300
Asp Leu Tyr Tyr Thr Thr Phe Ser Asp Pro Val Tyr Leu Thr Met Phe 
 305                310                315                320
Lys Met Leu Arg Asp Thr Leu Tyr Tyr Met Lys Asp Leu Pro Thr Ser 
                 325                330                335
Phe Val Lys Glu Ile His Asp Phe Val Leu Glu Gln Phe Asn Met Ser 
             340                345                350
Gln Gly Glu Leu Gln Lys Ile Leu His Asp Ala Asp Arg Ile His Ser 
         355                360                365
Glu Met Ser Pro Leu Lys Leu Arg Cys Gln Ala Asn Ala Ala Cys Val 
     370                375                380
Asp Leu Met Val Trp Ala Val Lys Asp Glu Gln Gly Ala Glu Asn Leu 
 385                390                395                400
Cys Ile Lys Leu Ser Glu Lys Leu Gln Ser Lys Thr Ser Ser Lys Val 
                 405                410                415
Ile Ile Ala His Leu Pro Leu Leu Ile Cys Cys Leu Gln Gly Leu Gly 
             420                425                430
Arg Leu Cys Glu Arg Phe Pro Val Val Val His Ser Val Thr Pro Ser 
         435                440                445
Leu Arg Asp Phe Leu Val Ile Pro Ser Pro Val Leu Val Lys Leu Tyr 
     450                455                460
Lys Tyr His Ser Gln Tyr His Thr Val Ala Gly Ser Asp Ile Lys Ile 
 465                470                475                480
Ser Val Thr Asn Glu His Ser Glu Ser Thr Leu Asn Val Leu Pro Gly 
                 485                490                495
Lys Lys Asn Gln Pro Ser Met Tyr Glu Gln Leu Arg Asp Ile Ala Ile 
             500                505                510
Asp Asn Ile Cys Arg Cys Leu Lys Ala Gly Leu Thr Val Asp Pro Val 
         515                520                525
Ile Val Glu Ala Phe Leu Ala Ser Leu Ser Asn Arg Leu Tyr Ile Ser 
     530                535                540
Gln Glu Ser Asp Lys Asp Ala His Leu Ile Pro Asp His Thr Ile Arg 
 545                550                555                560
Ala Leu Gly His Ile Ala Val Ala Leu Arg Asp Thr Pro Lys Val Met 
                 565                570                575
Glu Pro Ile Leu Gln Gln Lys Phe Cys Gln Pro Pro Ser Pro Leu Asp 
             580                585                590
Val Leu Ile Ile Asp Gln Leu Gly Cys Leu Val Ile Thr Gly Asn Gln 
         595                600                605
Tyr Ile Tyr Gln Glu Val Trp Asn Leu Phe Gln Gln Ile Ser Val Lys 
     610                615                620
Ala Ser Ser Val Val Tyr Ser Ala Thr Lys Asp Tyr Lys Asp His Gly 
 625                630                635                640
Tyr Arg His Cys Ser Leu Ala Val Ile Asn Ala Leu Ala Asn Ile Ala 
                 645                650                655
Ala Asn Ile Gln Glu Glu His Leu Val Asp Glu Leu Leu Met Asn Leu 
             660                665                670
Leu Glu Leu Phe Val Gln Leu Gly Leu Glu Gly Lys Arg Ala Ser Glu 
         675                680                685
Arg Ala Ser Glu Lys Gly Pro Ala Leu Lys Ala Ser Ser Ser Ala Gly 
     690                695                700
Asn Leu Gly Val Leu Ile Pro Val Ile Ala Val Leu Thr Arg Arg Leu 
 705                710                715                720
Pro Pro Ile Lys Glu Ala Lys Pro Arg Leu Gln Lys Leu Phe Arg Asp 
                 725                730                735
Phe Trp Leu Tyr Ser Val Leu Met Gly Phe Ala Val Glu Gly Ser Gly 
             740                745                750
Leu Trp Pro Glu Glu Trp Tyr Glu Gly Val Cys Glu Ile Ala Thr Lys 
         755                760                765
Ser Pro Leu Leu Thr Phe Pro Ser Lys Glu Pro Leu Arg Ser Val Leu 
     770                775                780
Gln Tyr Asn Ser Ala Met Lys Asn Asp Thr Val Thr Pro Ala Glu Leu 
 785                790                795                800
Asn Glu Leu Arg Ser Thr Ile Ile Asn Leu Leu Asp Pro Pro Pro Glu 
                 805                810                815
Val Ser Ala Leu Ile Asn Lys Leu Asp Phe Ala Met Ser Thr Tyr Leu 
             820                825                830
Leu Ser Val Tyr Arg Leu Glu Tyr Met Arg Val Leu Arg Ser Thr Asp 
         835                840                845
Pro Asp Arg Phe Gln Val Met Phe Cys Tyr Phe Glu Asp Lys Ala Ile 
     850                855                860
Gln Lys Asp Lys Ser Gly Met Met Gln Cys Val Ile Ala Val Ala Asp 
 865                870                875                880
Lys Val Phe Asp Ala Phe Leu Asn Met Met Ala Glu Lys Ala Lys Thr 
                 885                890                895
Lys Glu Asn Glu Glu Glu Leu Glu Arg His Ala Gln Phe Leu Leu Val 
             900                905                910
Asn Phe Asn His Ile His Lys Arg Ile Arg Arg Val Ala Asp Lys Tyr 
         915                920                925
Leu Ser Gly Leu Val Asp Lys Phe Pro His Leu Leu Trp Ser Gly Thr 
     930                935                940
Val Leu Lys Thr Met Leu Asp Ile Leu Gln Thr Leu Ser Leu Ser Leu 
 945                950                955                960
Ser Ala Asp Ile His Lys Asp Gln Pro Tyr Tyr Asp Ile Pro Asp Ala 
                 965                970                975
Pro Tyr Arg Ile Thr Val Pro Asp Thr Tyr Glu Ala Arg Glu Ser Ile 
             980                985                990
Val Lys Asp Phe Ala Ala Arg Cys Gly Met Ile Leu Gln Glu Ala Met 
         995                1000                1005
Lys Trp Ala Pro Thr Val Thr Lys Ser His Leu Gln Glu Tyr Leu Asn 
     1010                1015                1020
Lys His Gln Asn Trp Val Ser Gly Leu Ser Gln His Thr Gly Leu Ala 
 1025                1030                1035                1040
Met Ala Thr Glu Ser Ile Leu His Phe Ala Gly Tyr Asn Lys Gln Asn 
                 1045                1050                1055
Thr Thr Leu Gly Val Thr Gln Leu Thr Glu Arg Pro Ala Cys Val Lys 
             1060                1065                1070
Lys Asp Tyr Ser Asn Phe Met Ala Ser Leu Asn Leu Arg Asn Arg Tyr 
         1075                1080                1085
Ala Gly Glu Val His Gly Met Ile Arg Phe Ser Gly Ala Thr Gly Gln 
     1090                1095                1100
Met Ser Asp Leu Asn Lys Met Met Val Gln Asp Leu Ile Thr Ala Leu 
 1105                1110                1115                1120
Asp His Ser His Pro Gln His Tyr Thr Gln Ala Met Phe Lys Leu Thr 
                 1125                1130                1135
Ala Met Leu Ile Ser Ser Lys Asp Cys Asp Pro Gln Leu Leu His His 
             1140                1145                1150
Leu Cys Trp Gly Pro Leu Arg Met Phe Asn Glu His Gly Met Glu Thr 
         1155                1160                1165
Ala Leu Ala Cys Trp Glu Trp Leu Leu Ala Gly Lys Asn Gly Val Glu 
     1170                1175                1180
Val Pro Phe Met Arg Glu Met Ala Gly Ala Trp His Met Thr Val Glu 
 1185                1190                1195                1200
Gln Lys Phe Gly Leu Phe Ser Ala Glu Thr Lys Glu Ala Asp Pro Leu 
                 1205                1210                1215
Ala Ala Ser Glu Ala Ser Gln Pro Arg Pro Cys Pro Pro Glu Val Thr 
             1220                1225                1230
Pro His Tyr Ile Trp Ile Asp Phe Leu Val Gln Arg Phe Glu Ile Ala 
         1235                1240                1245
Lys Tyr Cys Ser Ser Asp Gln Val Glu Ile Phe Ser Ser Leu Leu Gln 
     1250                1255                1260
Arg Ser Met Ser Leu His Ile Gly Gly Ala Arg Gly Ser Met Asn Arg 
 1265                1270                1275                1280
His Val Ala Ala Ile Gly Pro Arg Phe Lys Leu Leu Thr Leu Gly Leu 
                 1285                1290                1295
Ser Leu Leu His Ala Asp Val Val Pro Asn Ala Thr Ile Arg Asn Val 
             1300                1305                1310
Leu Arg Glu Lys Ile Tyr Ser Thr Ala Phe Asp Tyr Phe Ser Cys Pro 
         1315                1320                1325
Pro Lys Phe Pro Thr Gln Gly Glu Lys Arg Leu Arg Glu Asp Ile Ser 
     1330                1335                1340
Ile Met Ile Lys Phe Trp Thr Ala Met Phe Ser Asp Lys Lys Tyr Leu 
 1345                1350                1355                1360
Thr Ala Ser Gln Leu Val Pro Pro Asp Asn Gln Asp Thr Arg Ser Asn 
                 1365                1370                1375
Leu Asp Ile Thr Val Gly Ser Arg Gln Gln Ala Thr Gln Gly Trp Ile 
             1380                1385                1390
Asn Thr Tyr Pro Leu Ser Ser Gly Met Ser Thr Ile Ser Lys Lys Ser 
         1395                1400                1405
Gly Met Ser Lys Lys Thr Asn Arg Gly Ser Gln Leu His Lys Tyr Tyr 
     1410                1415                1420
Met Lys Arg Arg Thr Leu Leu Leu Ser Leu Leu Ala Thr Glu Ile Glu 
 1425                1430                1435                1440
Arg Leu Ile Thr Trp Tyr Asn Pro Leu Ser Ala Pro Glu Leu Glu Leu 
                 1445                1450                1455
Asp Gln Ala Gly Glu Asn Ser Val Ala Asn Trp Arg Ser Lys Tyr Ile 
             1460                1465                1470
Ser Leu Ser Glu Lys Gln Trp Lys Asp Asn Val Asn Leu Ala Trp Thr 
         1475                1480                1485
Ile Ser Pro Tyr Leu Ala Val Gln Leu Pro Ala Arg Phe Lys Asn Thr 
     1490                1495                1500
Glu Ala Ile Gly Asn Glu Val Thr Arg Leu Val Arg Leu Asp Pro Gly 
 1505                1510                1515                1520
Ala Val Ser Asp Val Pro Glu Ala Ile Lys Phe Leu Val Thr Trp His 
                 1525                1530                1535
Thr Ile Asp Ala Asp Ala Pro Glu Leu Ser His Val Leu Cys Trp Ala 
             1540                1545                1550
Pro Thr Asp Pro Pro Thr Gly Leu Ser Tyr Phe Ser Ser Met Tyr Pro 
         1555                1560                1565
Pro His Pro Leu Thr Ala Gln Tyr Gly Val Lys Val Leu Arg Ser Phe 
     1570                1575                1580
Pro Pro Asp Ala Ile Leu Phe Tyr Ile Pro Gln Ile Val Gln Ala Leu 
 1585                1590                1595                1600
Arg Tyr Asp Lys Met Gly Tyr Val Arg Glu Tyr Ile Leu Trp Ala Ala 
                 1605                1610                1615
Ala Lys Ser Gln Leu Leu Ala His Gln Phe Ile Trp Asn Met Lys Thr 
             1620                1625                1630
Asn Ile Tyr Leu Asp Glu Glu Gly His Gln Lys Asp Pro Asp Ile Gly 
         1635                1640                1645
Asp Leu Leu Glu Gln Leu Val Glu Glu Ile Thr Gly Ser Leu Ser Gly 
     1650                1655                1660
Pro Ala Lys Asp Phe Tyr Gln Arg Glu Phe Asp Phe Phe Asn Lys Ile 
 1665                1670                1675                1680
Thr Asn Val Ser Ala Ile Ile Lys Pro Tyr Pro Lys Gly Asp Glu Arg 
                 1685                1690                1695
Lys Lys Ala Cys Leu Ser Ala Leu Ser Glu Val Lys Val Gln Pro Gly 
             1700                1705                1710
Cys Tyr Leu Pro Ser Asn Pro Glu Ala Ile Val Leu Asp Ile Asp Tyr 
         1715                1720                1725
Lys Ser Gly Thr Pro Met Gln Ser Ala Ala Lys Ala Pro Tyr Leu Ala 
     1730                1735                1740
Lys Phe Lys Val Lys Arg Cys Gly Val Ser Glu Leu Glu Lys Glu Gly 
 1745                1750                1755                1760
Leu Gln Cys Arg Ser Asp Thr Glu Asp Glu Cys Arg Arg Gln Glu Ala 
                 1765                1770                1775
Asp Gly Lys Lys Ile Cys Trp Gln Ala Ala Ile Phe Lys Val Gly Asp 
             1780                1785                1790
Asp Cys Arg Gln Asp Met Leu Ala Leu Gln Ile Ile Asp Leu Phe Lys 
         1795                1800                1805
Asn Ile Phe Gln Leu Val Gly Leu Asp Leu Phe Val Phe Pro Tyr Arg 
     1810                1815                1820
Val Val Ala Thr Ala Pro Gly Cys Gly Val Ile Glu Cys Ile Pro Asp 
 1825                1830                1835                1840
Cys Thr Ser Arg Asp Gln Leu Gly Arg Gln Thr Asp Phe Gly Met Tyr 
                 1845                1850                1855
Asp Tyr Phe Thr Arg Gln Tyr Gly Asp Glu Ser Thr Leu Ala Phe Gln 
             1860                1865                1870
Gln Ala Arg Tyr Asn Phe Ile Arg Ser Met Ala Ala Tyr Ser Leu Leu 
         1875                1880                1885
Leu Phe Leu Leu Gln Ile Lys Asp Arg His Asn Gly Asn Ile Met Leu 
     1890                1895                1900
Asp Lys Lys Gly His Ile Ile His Ile Asp Phe Gly Phe Met Phe Glu 
 1905                1910                1915                1920
Ser Ser Pro Gly Gly Asn Leu Gly Trp Glu Pro Asp Ile Lys Leu Thr 
                 1925                1930                1935
Asp Glu Met Val Met Ile Met Gly Gly Lys Met Glu Ala Thr Pro Phe 
             1940                1945                1950
Lys Trp Phe Met Glu Met Cys Val Arg Gly Tyr Leu Ala Val Arg Pro 
         1955                1960                1965
Tyr Met Asp Ala Val Val Ser Leu Val Thr Leu Met Leu Asp Thr Gly 
     1970                1975                1980
Leu Pro Cys Phe Arg Gly Gln Thr Ile Lys Leu Leu Lys His Arg Phe 
 1985                1990                1995                2000
Ser Pro Asn Met Thr Glu Arg Glu Ala Ala Asn Phe Ile Met Lys Ile 
                 2005                2010                2015
Ile Gln Asn Cys Phe Leu Ser Asn Arg Ser Arg Thr Tyr Asp Met Ile 
             2020                2025                2030
Gln Tyr Tyr Gln Asn Asp Ile Pro Tyr 
         2035                2040



<210> 2197
<211> 1787
<212> DNA
<213> Homo sapiens
<308> AK024034
<400> 2197

aaaaaatta  ctgggcatg  tggtgggca  ctgtagtcc  agctactcg  gaggctgag  60
caggagaat  tcttgaacc  aggaggcag  ggttgcagt  agccaagat  atgccactg  120
actccagcc  ggcgacaga  cgagactcc  tttaaaaaa  aaaacacca  ggcatctgt  180
agccacttt  ggagtcaaa  gaatgtaga  ctgggctgg  ctccttaga  gaaagttaa  240
ttctgagtg  gggaggaag  gcctgcacc  ccacatcca  acagcccgt  actcctgct  300
ccgaagact  acttgctga  tcgggctct  cctccatag  gggggcaca  agccaggga  360
agtgcccac  ggcccaggg  tcctgggtg  gggaccagg  agaatgccc  caggcccca  420
ggccttttt  agcccaggg  gctctctgc  caggcctgc  acaacttca  ccgaagcat  480
gccgcctac  gcctcctgc  gttcctgct  cagatcaag  acagacaca  cggcaacat  540
atgctggac  agaagggcc  tatcatcca  atcggtcag  cagccacag  gccaccctc  600
tctcccttc  ccccggcac  caggggtgg  tagggatcc  caccccaca  agaggagaa  660
gcccaggac  accctgcca  gagtgtcag  gtccagctc  gaggtccga  ctgtcggcc  720
ccaagctgt  ctgctgtag  gggtgcctg  ccccggccc  agggagctg  ggcgagagc  780
gccattgct  tgagtcaga  gctggagct  ggcggagtg  ggctcgtcc  ggttcagtg  840
cccagcttg  ctccttcct  cacttcctc  cttctcttt  tctgcctgc  gccccacca  900
ccaccccat  actgtctcc  agaaaacac  acctgcctt  tgggggtgg  gggggtgct  960
ctgttgcag  gtccttttc  actcctcaa  acagaccac  cgtccttgc  cgccctggc  1020
cctacccag  cacaggcag  tctttggtg  tttgcagac  ttggcttca  gtttgaaag  1080
tcgccgggc  gcaatctcg  ctgggaacc  gacatcaag  tgacggatg  gatggtgat  1140
atcatgggg  gcaagatgg  ggccacacc  ttcaagtgg  tcatggaga  gtgtgtcca  1200
gctacctgg  tgtgcggcc  tacatggat  tggtcgtct  cctggtcac  atcatgttg  1260
acacgggcc  gccctgttt  cgcggccag  caatcaagt  cttgaagca  aggtttagc  1320
ccaacatga  tgagcgcga  gctgcaaat  tcatcatga  ggtcatcca  agctgcttc  1380
tcagcaaca  gagccggac  tacaacatg  tccagtact  tcagaatga  atcccctac  1440
gaggagggg  ccttcgagg  cctctgccc  atgtgccct  gaagctgcc  cacaatcat  1500
gagccctgc  acctacccg  cctgccgcc  catgcagtg  aggagaggc  tgtggcccg  1560
agagcctgg  agcgcctcc  ggggcagca  gtgggtggc  caggcttag  aacgccgtg  1620
actgcagcg  caatcagtg  atggtgctg  ctatgcaca  gtgtgagtc  tctgtttgc  1680
ctggacata  tccctacct  ttttatttc  taggtacat  aagtattgt  tataaaaaa  1740
gagataaga  ttaaccaac  tcaacaaaa  aaaaaccca  aatagtg  1787



<210> 2198
<211> 854
<212> PRT
<213> Homo sapiens
<308> P42356
<400> 2198

Met Arg Glu Met Ala Gly Ala Trp His Met Thr Val Glu Gln Lys Phe 
  1               5                  10                  15
Gly Leu Phe Ser Ala Glu Ile Lys Glu Ala Asp Pro Leu Ala Ala Ser 
             20                  25                  30
Glu Ala Ser Gln Pro Lys Pro Cys Pro Pro Glu Val Thr Pro His Tyr 
         35                  40                  45
Ile Trp Ile Asp Phe Leu Val Gln Arg Phe Glu Ile Ala Lys Tyr Cys 
     50                  55                  60
Ser Ser Asp Gln Val Glu Ile Phe Ser Ser Leu Leu Gln Arg Ser Met 
 65                  70                  75                  80
Ser Leu Asn Ile Gly Gly Ala Lys Gly Ser Met Asn Arg His Val Ala 
                 85                  90                  95
Ala Ile Gly Pro Arg Phe Lys Leu Leu Thr Leu Gly Leu Ser Leu Leu 
             100                105                110
His Ala Asp Val Val Pro Asn Ala Thr Ile Arg Asn Val Leu Arg Glu 
         115                120                125
Lys Ile Tyr Ser Thr Ala Phe Asp Tyr Phe Ser Cys Pro Pro Lys Phe 
     130                135                140
Pro Thr Gln Gly Glu Lys Arg Leu Arg Glu Asp Ile Ser Ile Met Ile 
 145                150                155                160
Lys Phe Trp Thr Ala Met Phe Ser Asp Lys Lys Tyr Leu Thr Ala Ser 
                 165                170                175
Gln Leu Val Pro Pro Asp Asn Gln Asp Thr Arg Ser Asn Leu Asp Ile 
             180                185                190
Thr Val Gly Ser Arg Gln Gln Ala Thr Gln Gly Trp Ile Asn Thr Tyr 
         195                200                205
Pro Leu Ser Ser Gly Met Ser Thr Ile Ser Lys Lys Ser Gly Met Ser 
     210                215                220
Lys Lys Thr Asn Arg Gly Ser Gln Leu His Lys Tyr Tyr Met Lys Arg 
 225                230                235                240
Arg Thr Leu Leu Leu Ser Leu Leu Ala Thr Glu Ile Glu Arg Leu Ile 
                 245                250                255
Thr Trp Tyr Asn Pro Leu Ser Ala Pro Glu Leu Glu Leu Asp Gln Ala 
             260                265                270
Gly Glu Asn Ser Val Ala Asn Trp Arg Ser Lys Tyr Ile Ser Leu Ser 
         275                280                285
Glu Lys Gln Trp Lys Asp Asn Val Asn Leu Ala Trp Ser Ile Ser Pro 
     290                295                300
Tyr Leu Ala Val Gln Leu Pro Ala Arg Phe Lys Asn Thr Glu Ala Ile 
 305                310                315                320
Gly Asn Glu Val Thr Arg Leu Val Arg Leu Asp Pro Gly Ala Val Ser 
                 325                330                335
Asp Val Pro Glu Ala Ile Lys Phe Leu Val Thr Trp His Thr Ile Asp 
             340                345                350
Ala Asp Ala Pro Glu Leu Ser His Val Leu Cys Trp Ala Pro Thr Asp 
         355                360                365
Pro Pro Thr Gly Leu Ser Tyr Phe Ser Ser Met Tyr Pro Pro His Pro 
     370                375                380
Leu Thr Ala Gln Tyr Gly Val Lys Val Leu Arg Ser Phe Pro Pro Asp 
 385                390                395                400
Ala Ile Leu Phe Tyr Ile Pro Gln Ile Val Gln Ala Leu Arg Tyr Asp 
                 405                410                415
Lys Met Gly Tyr Val Arg Glu Tyr Ile Leu Trp Ala Ala Ser Lys Ser 
             420                425                430
Gln Leu Leu Ala His Gln Phe Ile Trp Asn Met Lys Thr Asn Ile Tyr 
         435                440                445
Leu Asp Glu Glu Gly His Gln Lys Asp Pro Asp Ile Gly Asp Leu Leu 
     450                455                460
Asp Gln Leu Val Glu Glu Ile Thr Gly Ser Leu Ser Gly Pro Ala Lys 
 465                470                475                480
Asp Phe Tyr Gln Arg Glu Phe Asp Phe Phe Asn Lys Ile Thr Asn Val 
                 485                490                495
Ser Ala Ile Ile Lys Pro Tyr Pro Lys Gly Asp Glu Arg Lys Lys Ala 
             500                505                510
Cys Leu Ser Ala Leu Ser Glu Val Lys Val Gln Pro Gly Cys Tyr Leu 
         515                520                525
Pro Ser Asn Pro Glu Ala Ile Val Leu Asp Ile Asp Tyr Lys Ser Gly 
     530                535                540
Thr Pro Met Gln Ser Ala Ala Lys Ala Pro Tyr Leu Ala Lys Phe Lys 
 545                550                555                560
Val Lys Arg Cys Gly Val Ser Glu Leu Glu Lys Glu Gly Leu Arg Cys 
                 565                570                575
Arg Ser Asp Ser Glu Asp Glu Cys Ser Thr Gln Glu Ala Asp Gly Gln 
             580                585                590
Lys Ile Ser Trp Gln Ala Ala Ile Phe Lys Val Gly Asp Asp Cys Arg 
         595                600                605
Gln Asp Met Leu Ala Leu Gln Ile Ile Asp Leu Phe Lys Asn Ile Phe 
     610                615                620
Gln Leu Val Gly Leu Asp Leu Phe Val Phe Pro Tyr Arg Val Val Ala 
 625                630                635                640
Thr Ala Pro Gly Cys Gly Val Ile Glu Cys Ile Pro Asp Cys Thr Ser 
                 645                650                655
Arg Asp Gln Leu Gly Arg Gln Thr Asp Phe Gly Met Tyr Asp Tyr Phe 
             660                665                670
Thr Arg Gln Tyr Gly Asp Glu Ser Thr Leu Ala Phe Gln Gln Ala Arg 
         675                680                685
Tyr Asn Phe Ile Arg Ser Met Ala Ala Tyr Ser Leu Leu Leu Phe Leu 
     690                695                700
Leu Gln Ile Lys Asp Arg His Asn Gly Asn Ile Met Leu Asp Lys Lys 
 705                710                715                720
Gly His Ile Ile His Ile Asp Phe Gly Phe Met Phe Glu Ser Ser Pro 
                 725                730                735
Gly Gly Asn Leu Gly Trp Glu Pro Asp Ile Lys Leu Thr Asp Glu Met 
             740                745                750
Val Met Ile Met Gly Gly Lys Met Glu Ala Thr Pro Phe Lys Trp Phe 
         755                760                765
Met Glu Met Cys Val Arg Gly Tyr Leu Ala Val Arg Pro Tyr Met Asp 
     770                775                780
Ala Val Val Ser Leu Val Thr Leu Met Leu Asp Thr Gly Leu Pro Cys 
 785                790                795                800
Phe Arg Gly Gln Thr Ile Lys Leu Leu Lys His Arg Phe Ser Pro Asn 
                 805                810                815
Met Thr Glu Arg Glu Ala Ala Asn Phe Ile Met Lys Val Ile Gln Ser 
             820                825                830
Cys Phe Leu Ser Asn Arg Ser Arg Thr Tyr Asp Met Ile Gln Tyr Tyr 
         835                840                845
Gln Asn Asp Ile Pro Tyr 
     850



<210> 2199
<211> 6857
<212> DNA
<213> Rattus norvegicus
<308> D83538
<400> 2199

ttccagaat  gatagtggt  cggcccacc  ctgaaggtt  cagaatcga  agtggttcg  60
cccacctct  aaggttcca  aatcgatag  ggttcggcc  acctctgaa  gttccagaa  120
cgatagtgg  tcggcccac  tctgatggt  ccagcacct  ccgaggttt  tatttcaac  180
cagtgcttt  actggcccg  tccctggct  tgcagagac  tgcatccct  gagaaggtt  240
aaaattcgg  ccacctctg  aggttccag  atcgatagg  tctggttcc  gcacctccc  300
aggttttta  ttcaacaca  tgccttcac  ggcccgctc  ctggctgtg  agagacctg  360
atccttaga  aaggttcaa  agctgctgt  catgtgccc  gtagatttt  atggaatct  420
ccagctaga  gaaagacgg  gagatgcag  gattgctct  ggcattttt  tcattgagt  480
tgatcttca  cacaaagat  gtattgttc  ttatcttct  cgacttctc  ggggtcttc  540
aaaagtcta  tgggtagaa  aaagcacag  tcggaaagg  agaggtaac  tcccggttg  600
agaaagctt  agcttctgc  tggtgacct  gctgtctga  gtggcttgc  gggacccct  660
gcttaggga  gagatttta  aggcacttt  gcaggtttt  catgtcctt  tggggatgt  720
ccaggccct  gagattcaa  agaaagaat  cctttgcaa  tatgcaatc  catgcctga  780
agggatctc  aaatctttt  gacgttaca  caattcaga  gaatctctc  tctcaaagc  840
ttttcccaa  gtccctcct  attccctga  aatccccga  gagctagaa  gtgtccgaa  900
gcgttcctt  aatgacttc  gctccatcc  gcccagcaa  ctgctgact  tctgtcagg  960
gggcacact  aagaggaaa  ccagcagtg  gtccagcat  tctcaggtt  gcccagaac  1020
tggcatgcc  cctcccagc  cccctggag  atctgcttt  cactatttt  aagcctctt  1080
cctgcctga  ggaaccacc  tggagcccg  atactactt  tctaccatc  gctccagtt  1140
ttctgtctc  cccctgttc  atggtatca  ctataagga  ttctatatt  cactggaaa  1200
gcttcgaga  ctcttaaac  tggtaaaga  gattgttga  gagcctgtt  tcaagtcct  1260
agatgcagc  gtagccaga  tgatggagg  caatcccag  gctgaccta  actacacga  1320
cttcagtga  cccgtctac  tgaccatgt  caagatgct  cgagacact  tgtactata  1380
gaaagactt  cccacctcc  ttgtgaaag  gatccatga  tttgtgttg  agcagttca  1440
catgagcca  ggggaactc  aaaagattc  ccatgatgc  gacaggatc  acagtgaga  1500
gagcccact  aaactgcgc  gccaagcaa  tgctgcctg  gtagacctc  tggtgtggg  1560
tgtgaagga  gagcagggt  cagaaaacc  ttgcatcaa  ctgtctgaa  agctgcagt  1620
caagacatc  agcaaggtc  tcatcgccc  tttgccctt  ctgatctgc  gcctacagg  1680
tctgggccg  ctatgtgaa  ggttcccgg  ggtggtcca  tcagtgaca  catctttga  1740
agactttct  gtgattcca  ccccagtgc  ggtgaagct  tataagtac  acagtcagt  1800
ccacacagt  gctggcagt  atataaaaa  tagtgtcac  aatgagcat  ctgagtcaa  1860
tctgaatgt  ttgcccggc  agaagaacc  gccatccat  tatgagcag  tccgggaca  1920
cgccattga  aacatctgc  ggtgcctga  ggccggcct  accgtggac  ctgtgatcg  1980
ggaggcctt  ctggccagc  tctccaacc  gctctatat  tcccaggag  gcgataagg  2040
tgctcactt  attcctgac  ataccattc  tgccttggg  cacattgca  tggctctga  2100
ggatacccc  aaggtcatg  agccaattc  gcagcagaa  ttttgccag  ccccctcac  2160
cctcgatgt  ctcatcatc  accagctgg  ctgcctggt  atcactgga  atcaataca  2220
ttatcagga  gtgtggaat  tcttccaac  aatcagtgt  aaggccagt  cagttgtat  2280
ttcagccac  aaagactac  aagaccatg  ctacaggca  tgctccctc  cagtcatca  2340
tgccctggc  aacatcgca  ccaacattc  ggaggagca  cttgtggat  agctgttga  2400
gaacctgct  gaactgttt  tgcagctgg  gctggaggg  aagagagcc  gtgagaggg  2460
cagcgagaa  gggcccgcc  tgaaggctt  cagcagtgc  gggaatttg  gagtgctca  2520
tcctgtaat  gccgtgctc  cccgacgat  gccacccat  aaagaagct  aacctaggc  2580
acaaaagct  ttccgagac  tctggctct  ctctgtgct  atgggattc  ctgtggaag  2640
ctcagggct  tggccggaa  agtggtatg  aggagtctg  gaaatagca  ccaagtcac  2700
tctgcttac  tttcccagc  aagagcctc  tcgatcagt  ctccagtac  actcagcca  2760
gaaaaatga  acagtgacc  cggctgagc  gaatgagct  cgaagtacc  tcatcaact  2820
gctagatcc  cctcctgag  tgtctgccc  catcaacaa  ctggacttt  ccatgtcca  2880
ctatctctt  tctgtgtat  ggctggaat  catgagggt  ctgcgttct  cagatccag  2940
tcgcttcca  gtaatgttc  gctacttcg  ggataaagc  attcagaaa  acaaatctg  3000
gatgatgca  tgtgtcatc  ctgttgctg  caaagtatt  gatgccttc  tgaacatga  3060
ggcagaaaa  gccaagacc  aggagaatg  agaggagtt  gagcggcat  cccagtttc  3120
gctggtgaa  ttcaaccac  ttcacaaga  gatacgcag  gtggctgac  agtacctgt  3180
tggtctggt  gataagttt  cacacttgc  ctggagtgg  actgtgctg  agaccatgt  3240
ggacatcct  cagaccctg  cactatcac  aagtgctga  attcacaag  accaacctt  3300
ttatgacat  cctgacgcc  cctatcgga  cacggttcc  gacacgtat  aagcccggg  3360
gagcatcgt  aaagacttt  ctgcacgct  tgggatgat  ctgcaggaa  ccatgaagt  3420
ggcacccac  gtcactaag  cccacctgc  ggaatatct  aacaagcat  agaactggg  3480
gtcaggact  tcccagcac  cgggattgg  catggccac  gagagcatc  ttcactttg  3540
cggctacaa  aagcagaac  caactcttg  ggtaactca  ctcactgag  gcccggcct  3600
tgtgaagaa  gactactcc  acttcatgg  atccttgaa  ttgcgcaac  gctatgccg  3660
cgaggtgca  gggatgatt  ggttctcag  tgccacagg  cagatgtcc  acctgaaca  3720
aatgatggt  caggatctg  ttacagctc  ggaccacag  catcctcag  actataccc  3780
agccatgtt  aaattgacg  ccatgctca  tagcagcaa  gattgtgac  cacagctcc  3840
tcatcatct  tgttggggt  ccctccgga  gttcaacga  catggcatg  agactgcac  3900
agcctgctg  gagtggctg  tggctggca  gaatggagt  gaagtgccg  tcatgcggg  3960
gatggcagg  gcctggcac  tgacagtgg  gcagaagtt  ggcctcttc  ctgcagaaa  4020
aaaggaagc  gaccccctg  cagcgtcag  agcaagtca  ccacgaccc  gtccccctg  4080
agtgacacc  cactacatc  ggattgatt  cctggtgca  cggtttgag  ttgccaagt  4140
ctgtagctc  gaccaggtg  agatcttct  aagcctgct  cagcgctcc  tgtccctcc  4200
catcggtgg  gccaggggg  gcatgaaca  gcatgtggc  gccattgga  cacgtttca  4260
actgctgac  ctggggctg  ccctcctac  cgctgatgt  gttccaaat  caaccattc  4320
aaacgtgct  cgagagaag  tctactcaa  agcctttga  tatttcagt  gtccaccaa  4380
gttccctac  caaggagaa  agaggctgc  tgaagatat  agcatcatg  ttaagtttt  4440
gactgccat  ttctcagat  agaagtacc  gactgccag  caactcgtt  ccccagata  4500
ccaggacac  cgaagcaac  tggatataa  tgtgggctc  cgacaacag  ctacacagg  4560
atggatcaa  acatacccc  tctccagtg  catgtcaac  atctccaaa  aatcaggca  4620
gtctaagaa  accaaccga  gttcccagc  gcacaagta  tacatgaag  gtaggacgc  4680
gctgctgtc  ctgttggcc  ctgagatcg  gcgcctcat  acttggtac  acccgctgt  4740
agccccaga  ctagagctg  accaggcag  tgagaacag  gttgccaac  ggaggtcca  4800
gtatatcag  ctgagtgag  agcagtgga  ggacaacgt  aaccttgcc  ggaccatct  4860
tccatacct  gctgtgcag  tgccagcca  gttcaagaa  acagaagcc  ttggaaatg  4920
agtgacccg  ctcgttcgc  tggacccag  agctgttag  gatgtccct  aagctatca  4980
gttccttgt  acctggcac  ccatcgatg  tgatgctcc  gagcttagc  atgtgttat  5040
ctgggcacc  acggacccg  ccacgggcc  ctcctactt  tccagcatg  accccccac  5100
ccctctcac  gcacagtat  gggtgaaag  cctgcggtc  ttccctccg  atgccattc  5160
gttctacat  ccccagatt  tgcaggccc  cagatatga  aagatgggc  atgtgcgcg  5220
gtacattct  tgggctgca  ccaaatccc  gcttctggc  caccagttt  tttggaata  5280
gaaaactaa  atctacctt  atgaagaag  gcaccagaa  gaccctgac  ttggtgacc  5340
tctggagca  ttagtagaa  aaatcacag  gtctctatc  ggcccagcc  aagatttct  5400
tcaacggga  tttgatttc  ttaacaaga  caccaacgt  tcagctatc  tcaagccct  5460
ccctaaagg  gatgaaaga  agaaggctt  tctgtcagc  ctgtctgaa  tgaaggtgc  5520
gcctggctg  tacctgccc  gcaaccctg  agcaattgt  ctagacatt  actacaagt  5580
agggacacc  atgcagagt  ctgcaaaag  gccgtatct  gccaagttt  aggtgaagc  5640
atgcggagt  agtgaactt  aaaaagaag  tctgcagtg  cgctcagac  cagaggatg  5700
gtgccgcag  caagaggct  atggcaaga  gatctgctg  caagcagcc  tcttcaaag  5760
gggggatga  tgccgacag  acatgctag  cctgcagat  atcgacctt  tcaagaaca  5820
cttccagct  gttggcctg  acctcttcg  ttttcccta  cgggtagtg  ctactgccc  5880
tgggtgtgg  gtgattgag  gcattccag  ctgtacctc  cgagaccag  taggccgcc  5940
gactgactt  ggcatgtat  actacttta  acgccagta  ggggacgag  ctaccttgg  6000
cttccagca  gcacgctac  actttatca  aagcatggc  gcctacagc  tcctgctgt  6060
cctgctgca  atcaaggac  ggcacaacg  caacatcat  ctggacaag  agggacaca  6120
catccacat  gactttggc  tcatgtttg  aagctcacc  ggtggcaac  ttggctggg  6180
gccagacat  aagctgaca  acgagatgg  gatgattat  gggggcaag  tggaagcca  6240
acccttcaa  tggttcatg  agatgtgcg  ccgaggtta  ctggctgtg  gcccctata  6300
ggatgcagt  gtctccctg  ttacactca  gttggacac  ggcctgccc  gtttccgtg  6360
ccagacaat  aaacttttg  aacacaggt  cagcccgaa  atgacagag  gggaggctg  6420
aaattttat  atgaagatc  tccaaaact  tttcctcag  aacaggagc  ggacctacg  6480
catgatcca  tactaccag  atgatatcc  ctactgagg  gactgtacc  gaagccttg  6540
gtgtcacag  gcagcttgt  ctgtcacca  aagcctggg  gtggaggtg  caggcacat  6600
gaacttgga  gcacaggtg  gagtctttt  cacactgga  acattccct  tttgttcac  6660
catcttact  tgttggtac  tgaagtatt  tcctgtgta  acatgagaa  ttgacataa  6720
aaataagaa  cctaaaatg  gctacttct  tttgttagg  caccaagac  ttgtcctta  6780
tcaaaggta  cctttgaat  cctggtcct  ccaactcac  cctagctta  tcttgcttt  6840
atttggtcc  gaggatc  6857



<210> 2200
<211> 2041
<212> PRT
<213> Rattus norvegicus
<308> BAA19614
<400> 2200

Met Cys Pro Val Asp Phe His Gly Ile Phe Gln Leu Asp Glu Arg Arg 
  1               5                  10                  15
Arg Asp Ala Val Ile Ala Leu Gly Ile Phe Leu Ile Glu Ser Asp Leu 
             20                  25                  30
Gln His Lys Asp Cys Ile Val Pro Tyr Leu Leu Arg Leu Leu Arg Gly 
         35                  40                  45
Leu Pro Lys Val Tyr Trp Val Glu Glu Ser Thr Ala Arg Lys Gly Arg 
     50                  55                  60
Gly Asn Leu Pro Val Ala Glu Ser Phe Ser Phe Cys Leu Val Thr Leu 
 65                  70                  75                  80
Leu Ser Asp Val Ala Cys Arg Asp Pro Ser Leu Arg Asp Glu Ile Leu 
                 85                  90                  95
Glu Ala Leu Leu Gln Val Leu His Val Leu Leu Gly Met Cys Gln Ala 
             100                105                110
Leu Glu Ile Gln Glu Lys Glu Tyr Leu Cys Lys Tyr Ala Ile Pro Cys 
         115                120                125
Leu Ile Gly Ile Ser Lys Ser Phe Gly Arg Tyr Ser Asn Ser Glu Glu 
     130                135                140
Ser Leu Leu Ser Lys Leu Phe Pro Lys Val Pro Pro His Ser Leu Arg 
 145                150                155                160
Ile Pro Glu Glu Leu Glu Gly Val Arg Arg Arg Ser Phe Asn Asp Phe 
                 165                170                175
Arg Ser Ile Leu Pro Ser Asn Leu Leu Thr Val Cys Gln Glu Gly Thr 
             180                185                190
Leu Lys Arg Lys Thr Ser Ser Val Ser Ser Ile Ser Gln Val Ser Pro 
         195                200                205
Glu Arg Gly Met Pro Pro Pro Ser Ser Pro Gly Gly Ser Ala Phe His 
     210                215                220
Tyr Phe Glu Ala Ser Cys Leu Pro Asp Gly Thr Thr Leu Glu Pro Glu 
 225                230                235                240
Tyr Tyr Phe Ser Thr Ile Ser Ser Ser Phe Ser Val Ser Pro Leu Phe 
                 245                250                255
Asn Gly Ile Thr Tyr Lys Glu Phe Tyr Ile Pro Leu Glu Met Leu Arg 
             260                265                270
Glu Leu Leu Asn Leu Val Lys Lys Ile Val Glu Glu Pro Val Leu Lys 
         275                280                285
Ser Leu Asp Ala Ala Val Ala Arg Val Met Glu Ala Asn Pro Ser Ala 
     290                295                300
Asp Leu Tyr Tyr Thr Thr Phe Ser Asp Pro Val Tyr Leu Thr Met Phe 
 305                310                315                320
Lys Met Leu Arg Asp Thr Leu Tyr Tyr Met Lys Asp Leu Pro Thr Ser 
                 325                330                335
Phe Val Lys Glu Ile His Asp Phe Val Leu Glu Gln Phe Asn Met Ser 
             340                345                350
Gln Gly Glu Leu Gln Lys Ile Leu His Asp Ala Asp Arg Ile His Ser 
         355                360                365
Glu Met Ser Pro Leu Lys Leu Arg Cys Gln Ala Asn Ala Ala Cys Val 
     370                375                380
Asp Leu Met Val Trp Ala Val Lys Asp Glu Gln Gly Ala Glu Asn Leu 
 385                390                395                400
Cys Ile Lys Leu Ser Glu Lys Leu Gln Ser Lys Thr Ser Ser Lys Val 
                 405                410                415
Ile Ile Ala His Leu Pro Leu Leu Ile Cys Cys Leu Gln Gly Leu Gly 
             420                425                430
Arg Leu Cys Glu Arg Phe Pro Val Val Val His Ser Val Thr Pro Ser 
         435                440                445
Leu Arg Asp Phe Leu Val Ile Pro Ser Pro Val Leu Val Lys Leu Tyr 
     450                455                460
Lys Tyr His Ser Gln Tyr His Thr Val Ala Gly Ser Asp Ile Lys Ile 
 465                470                475                480
Ser Val Thr Asn Glu His Ser Glu Ser Thr Leu Asn Val Leu Pro Gly 
                 485                490                495
Lys Lys Asn Gln Pro Ser Met Tyr Glu Gln Leu Arg Asp Ile Ala Ile 
             500                505                510
Asp Asn Ile Cys Arg Cys Leu Lys Ala Gly Leu Thr Val Asp Pro Val 
         515                520                525
Ile Val Glu Ala Phe Leu Ala Ser Leu Ser Asn Arg Leu Tyr Ile Ser 
     530                535                540
Gln Glu Ser Asp Lys Asp Ala His Leu Ile Pro Asp His Thr Ile Arg 
 545                550                555                560
Ala Leu Gly His Ile Ala Val Ala Leu Arg Asp Thr Pro Lys Val Met 
                 565                570                575
Glu Pro Ile Leu Gln Gln Lys Phe Cys Gln Pro Pro Ser Pro Leu Asp 
             580                585                590
Val Leu Ile Ile Asp Gln Leu Gly Cys Leu Val Ile Thr Gly Asn Gln 
         595                600                605
Tyr Ile Tyr Gln Glu Val Trp Asn Leu Phe Gln Gln Ile Ser Val Lys 
     610                615                620
Ala Ser Ser Val Val Tyr Ser Ala Thr Lys Asp Tyr Lys Asp His Gly 
 625                630                635                640
Tyr Arg His Cys Ser Leu Ala Val Ile Asn Ala Leu Ala Asn Ile Ala 
                 645                650                655
Ala Asn Ile Gln Glu Glu His Leu Val Asp Glu Leu Leu Met Asn Leu 
             660                665                670
Leu Glu Leu Phe Val Gln Leu Gly Leu Glu Gly Lys Arg Ala Ser Glu 
         675                680                685
Arg Ala Ser Glu Lys Gly Pro Ala Leu Lys Ala Ser Ser Ser Ala Gly 
     690                695                700
Asn Leu Gly Val Leu Ile Pro Val Ile Ala Val Leu Thr Arg Arg Leu 
 705                710                715                720
Pro Pro Ile Lys Glu Ala Lys Pro Arg Leu Gln Lys Leu Phe Arg Asp 
                 725                730                735
Phe Trp Leu Tyr Ser Val Leu Met Gly Phe Ala Val Glu Gly Ser Gly 
             740                745                750
Leu Trp Pro Glu Glu Trp Tyr Glu Gly Val Cys Glu Ile Ala Thr Lys 
         755                760                765
Ser Pro Leu Leu Thr Phe Pro Ser Lys Glu Pro Leu Arg Ser Val Leu 
     770                775                780
Gln Tyr Asn Ser Ala Met Lys Asn Asp Thr Val Thr Pro Ala Glu Leu 
 785                790                795                800
Asn Glu Leu Arg Ser Thr Ile Ile Asn Leu Leu Asp Pro Pro Pro Glu 
                 805                810                815
Val Ser Ala Leu Ile Asn Lys Leu Asp Phe Ala Met Ser Thr Tyr Leu 
             820                825                830
Leu Ser Val Tyr Arg Leu Glu Tyr Met Arg Val Leu Arg Ser Thr Asp 
         835                840                845
Pro Asp Arg Phe Gln Val Met Phe Cys Tyr Phe Glu Asp Lys Ala Ile 
     850                855                860
Gln Lys Asp Lys Ser Gly Met Met Gln Cys Val Ile Ala Val Ala Asp 
 865                870                875                880
Lys Val Phe Asp Ala Phe Leu Asn Met Met Ala Glu Lys Ala Lys Thr 
                 885                890                895
Lys Glu Asn Glu Glu Glu Leu Glu Arg His Ala Gln Phe Leu Leu Val 
             900                905                910
Asn Phe Asn His Ile His Lys Arg Ile Arg Arg Val Ala Asp Lys Tyr 
         915                920                925
Leu Ser Gly Leu Val Asp Lys Phe Pro His Leu Leu Trp Ser Gly Thr 
     930                935                940
Val Leu Lys Thr Met Leu Asp Ile Leu Gln Thr Leu Ser Leu Ser Leu 
 945                950                955                960
Ser Ala Asp Ile His Lys Asp Gln Pro Tyr Tyr Asp Ile Pro Asp Ala 
                 965                970                975
Pro Tyr Arg Ile Thr Val Pro Asp Thr Tyr Glu Ala Arg Glu Ser Ile 
             980                985                990
Val Lys Asp Phe Ala Ala Arg Cys Gly Met Ile Leu Gln Glu Ala Met 
         995                1000                1005
Lys Trp Ala Pro Thr Val Thr Lys Ser His Leu Gln Glu Tyr Leu Asn 
     1010                1015                1020
Lys His Gln Asn Trp Val Ser Gly Leu Ser Gln His Thr Gly Leu Ala 
 1025                1030                1035                1040
Met Ala Thr Glu Ser Ile Leu His Phe Ala Gly Tyr Asn Lys Gln Asn 
                 1045                1050                1055
Thr Thr Leu Gly Val Thr Gln Leu Thr Glu Arg Pro Ala Cys Val Lys 
             1060                1065                1070
Lys Asp Tyr Ser Asn Phe Met Ala Ser Leu Asn Leu Arg Asn Arg Tyr 
         1075                1080                1085
Ala Gly Glu Val His Gly Met Ile Arg Phe Ser Gly Ala Thr Gly Gln 
     1090                1095                1100
Met Ser Asp Leu Asn Lys Met Met Val Gln Asp Leu Ile Thr Ala Leu 
 1105                1110                1115                1120
Asp His Ser His Pro Gln His Tyr Thr Gln Ala Met Phe Lys Leu Thr 
                 1125                1130                1135
Ala Met Leu Ile Ser Ser Lys Asp Cys Asp Pro Gln Leu Leu His His 
             1140                1145                1150
Leu Cys Trp Gly Pro Leu Arg Met Phe Asn Glu His Gly Met Glu Thr 
         1155                1160                1165
Ala Leu Ala Cys Trp Glu Trp Leu Leu Ala Gly Lys Asn Gly Val Glu 
     1170                1175                1180
Val Pro Phe Met Arg Glu Met Ala Gly Ala Trp His Met Thr Val Glu 
 1185                1190                1195                1200
Gln Lys Phe Gly Leu Phe Ser Ala Glu Thr Lys Glu Ala Asp Pro Leu 
                 1205                1210                1215
Ala Ala Ser Glu Ala Ser Gln Pro Arg Pro Cys Pro Pro Glu Val Thr 
             1220                1225                1230
Pro His Tyr Ile Trp Ile Asp Phe Leu Val Gln Arg Phe Glu Ile Ala 
         1235                1240                1245
Lys Tyr Cys Ser Ser Asp Gln Val Glu Ile Phe Ser Ser Leu Leu Gln 
     1250                1255                1260
Arg Ser Met Ser Leu His Ile Gly Gly Ala Arg Gly Ser Met Asn Arg 
 1265                1270                1275                1280
His Val Ala Ala Ile Gly Pro Arg Phe Lys Leu Leu Thr Leu Gly Leu 
                 1285                1290                1295
Ser Leu Leu His Ala Asp Val Val Pro Asn Ala Thr Ile Arg Asn Val 
             1300                1305                1310
Leu Arg Glu Lys Ile Tyr Ser Thr Ala Phe Asp Tyr Phe Ser Cys Pro 
         1315                1320                1325
Pro Lys Phe Pro Thr Gln Gly Glu Lys Arg Leu Arg Glu Asp Ile Ser 
     1330                1335                1340
Ile Met Ile Lys Phe Trp Thr Ala Met Phe Ser Asp Lys Lys Tyr Leu 
 1345                1350                1355                1360
Thr Ala Ser Gln Leu Val Pro Pro Asp Asn Gln Asp Thr Arg Ser Asn 
                 1365                1370                1375
Leu Asp Ile Thr Val Gly Ser Arg Gln Gln Ala Thr Gln Gly Trp Ile 
             1380                1385                1390
Asn Thr Tyr Pro Leu Ser Ser Gly Met Ser Thr Ile Ser Lys Lys Ser 
         1395                1400                1405
Gly Met Ser Lys Lys Thr Asn Arg Gly Ser Gln Leu His Lys Tyr Tyr 
     1410                1415                1420
Met Lys Arg Arg Thr Leu Leu Leu Ser Leu Leu Ala Thr Glu Ile Glu 
 1425                1430                1435                1440
Arg Leu Ile Thr Trp Tyr Asn Pro Leu Ser Ala Pro Glu Leu Glu Leu 
                 1445                1450                1455
Asp Gln Ala Gly Glu Asn Ser Val Ala Asn Trp Arg Ser Lys Tyr Ile 
             1460                1465                1470
Ser Leu Ser Glu Lys Gln Trp Lys Asp Asn Val Asn Leu Ala Trp Thr 
         1475                1480                1485
Ile Ser Pro Tyr Leu Ala Val Gln Leu Pro Ala Arg Phe Lys Asn Thr 
     1490                1495                1500
Glu Ala Ile Gly Asn Glu Val Thr Arg Leu Val Arg Leu Asp Pro Gly 
 1505                1510                1515                1520
Ala Val Ser Asp Val Pro Glu Ala Ile Lys Phe Leu Val Thr Trp His 
                 1525                1530                1535
Thr Ile Asp Ala Asp Ala Pro Glu Leu Ser His Val Leu Cys Trp Ala 
             1540                1545                1550
Pro Thr Asp Pro Pro Thr Gly Leu Ser Tyr Phe Ser Ser Met Tyr Pro 
         1555                1560                1565
Pro His Pro Leu Thr Ala Gln Tyr Gly Val Lys Val Leu Arg Ser Phe 
     1570                1575                1580
Pro Pro Asp Ala Ile Leu Phe Tyr Ile Pro Gln Ile Val Gln Ala Leu 
 1585                1590                1595                1600
Arg Tyr Asp Lys Met Gly Tyr Val Arg Glu Tyr Ile Leu Trp Ala Ala 
                 1605                1610                1615
Ala Lys Ser Gln Leu Leu Ala His Gln Phe Ile Trp Asn Met Lys Thr 
             1620                1625                1630
Asn Ile Tyr Leu Asp Glu Glu Gly His Gln Lys Asp Pro Asp Ile Gly 
         1635                1640                1645
Asp Leu Leu Glu Gln Leu Val Glu Glu Ile Thr Gly Ser Leu Ser Gly 
     1650                1655                1660
Pro Ala Lys Asp Phe Tyr Gln Arg Glu Phe Asp Phe Phe Asn Lys Ile 
 1665                1670                1675                1680
Thr Asn Val Ser Ala Ile Ile Lys Pro Tyr Pro Lys Gly Asp Glu Arg 
                 1685                1690                1695
Lys Lys Ala Cys Leu Ser Ala Leu Ser Glu Val Lys Val Gln Pro Gly 
             1700                1705                1710
Cys Tyr Leu Pro Ser Asn Pro Glu Ala Ile Val Leu Asp Ile Asp Tyr 
         1715                1720                1725
Lys Ser Gly Thr Pro Met Gln Ser Ala Ala Lys Ala Pro Tyr Leu Ala 
     1730                1735                1740
Lys Phe Lys Val Lys Arg Cys Gly Val Ser Glu Leu Glu Lys Glu Gly 
 1745                1750                1755                1760
Leu Gln Cys Arg Ser Asp Thr Glu Asp Glu Cys Arg Arg Gln Glu Ala 
                 1765                1770                1775
Asp Gly Lys Lys Ile Cys Trp Gln Ala Ala Ile Phe Lys Val Gly Asp 
             1780                1785                1790
Asp Cys Arg Gln Asp Met Leu Ala Leu Gln Ile Ile Asp Leu Phe Lys 
         1795                1800                1805
Asn Ile Phe Gln Leu Val Gly Leu Asp Leu Phe Val Phe Pro Tyr Arg 
     1810                1815                1820
Val Val Ala Thr Ala Pro Gly Cys Gly Val Ile Glu Cys Ile Pro Asp 
 1825                1830                1835                1840
Cys Thr Ser Arg Asp Gln Leu Gly Arg Gln Thr Asp Phe Gly Met Tyr 
                 1845                1850                1855
Asp Tyr Phe Thr Arg Gln Tyr Gly Asp Glu Ser Thr Leu Ala Phe Gln 
             1860                1865                1870
Gln Ala Arg Tyr Asn Phe Ile Arg Ser Met Ala Ala Tyr Ser Leu Leu 
         1875                1880                1885
Leu Phe Leu Leu Gln Ile Lys Asp Arg His Asn Gly Asn Ile Met Leu 
     1890                1895                1900
Asp Lys Lys Gly His Ile Ile His Ile Asp Phe Gly Phe Met Phe Glu 
 1905                1910                1915                1920
Ser Ser Pro Gly Gly Asn Leu Gly Trp Glu Pro Asp Ile Lys Leu Thr 
                 1925                1930                1935
Asp Glu Met Val Met Ile Met Gly Gly Lys Met Glu Ala Thr Pro Phe 
             1940                1945                1950
Lys Trp Phe Met Glu Met Cys Val Arg Gly Tyr Leu Ala Val Arg Pro 
         1955                1960                1965
Tyr Met Asp Ala Val Val Ser Leu Val Thr Leu Met Leu Asp Thr Gly 
     1970                1975                1980
Leu Pro Cys Phe Arg Gly Gln Thr Ile Lys Leu Leu Lys His Arg Phe 
 1985                1990                1995                2000
Ser Pro Asn Met Thr Glu Arg Glu Ala Ala Asn Phe Ile Met Lys Ile 
                 2005                2010                2015
Ile Gln Asn Cys Phe Leu Ser Asn Arg Ser Arg Thr Tyr Asp Met Ile 
             2020                2025                2030
Gln Tyr Tyr Gln Asn Asp Ile Pro Tyr 
         2035                2040



<210> 2201
<211> 1787
<212> DNA
<213> Homo sapiens
<308> AK024034
<400> 2201

aaaaaatta  ctgggcatg  tggtgggca  ctgtagtcc  agctactcg  gaggctgag  60
caggagaat  tcttgaacc  aggaggcag  ggttgcagt  agccaagat  atgccactg  120
actccagcc  ggcgacaga  cgagactcc  tttaaaaaa  aaaacacca  ggcatctgt  180
agccacttt  ggagtcaaa  gaatgtaga  ctgggctgg  ctccttaga  gaaagttaa  240
ttctgagtg  gggaggaag  gcctgcacc  ccacatcca  acagcccgt  actcctgct  300
ccgaagact  acttgctga  tcgggctct  cctccatag  gggggcaca  agccaggga  360
agtgcccac  ggcccaggg  tcctgggtg  gggaccagg  agaatgccc  caggcccca  420
ggccttttt  agcccaggg  gctctctgc  caggcctgc  acaacttca  ccgaagcat  480
gccgcctac  gcctcctgc  gttcctgct  cagatcaag  acagacaca  cggcaacat  540
atgctggac  agaagggcc  tatcatcca  atcggtcag  cagccacag  gccaccctc  600
tctcccttc  ccccggcac  caggggtgg  tagggatcc  caccccaca  agaggagaa  660
gcccaggac  accctgcca  gagtgtcag  gtccagctc  gaggtccga  ctgtcggcc  720
ccaagctgt  ctgctgtag  gggtgcctg  ccccggccc  agggagctg  ggcgagagc  780
gccattgct  tgagtcaga  gctggagct  ggcggagtg  ggctcgtcc  ggttcagtg  840
cccagcttg  ctccttcct  cacttcctc  cttctcttt  tctgcctgc  gccccacca  900
ccaccccat  actgtctcc  agaaaacac  acctgcctt  tgggggtgg  gggggtgct  960
ctgttgcag  gtccttttc  actcctcaa  acagaccac  cgtccttgc  cgccctggc  1020
cctacccag  cacaggcag  tctttggtg  tttgcagac  ttggcttca  gtttgaaag  1080
tcgccgggc  gcaatctcg  ctgggaacc  gacatcaag  tgacggatg  gatggtgat  1140
atcatgggg  gcaagatgg  ggccacacc  ttcaagtgg  tcatggaga  gtgtgtcca  1200
gctacctgg  tgtgcggcc  tacatggat  tggtcgtct  cctggtcac  atcatgttg  1260
acacgggcc  gccctgttt  cgcggccag  caatcaagt  cttgaagca  aggtttagc  1320
ccaacatga  tgagcgcga  gctgcaaat  tcatcatga  ggtcatcca  agctgcttc  1380
tcagcaaca  gagccggac  tacaacatg  tccagtact  tcagaatga  atcccctac  1440
gaggagggg  ccttcgagg  cctctgccc  atgtgccct  gaagctgcc  cacaatcat  1500
gagccctgc  acctacccg  cctgccgcc  catgcagtg  aggagaggc  tgtggcccg  1560
agagcctgg  agcgcctcc  ggggcagca  gtgggtggc  caggcttag  aacgccgtg  1620
actgcagcg  caatcagtg  atggtgctg  ctatgcaca  gtgtgagtc  tctgtttgc  1680
ctggacata  tccctacct  ttttatttc  taggtacat  aagtattgt  tataaaaaa  1740
gagataaga  ttaaccaac  tcaacaaaa  aaaaaccca  aatagtg  1787



<210> 2202
<211> 854
<212> PRT
<213> Homo sapiens
<308> P42356
<400> 2202

Met Arg Glu Met Ala Gly Ala Trp His Met Thr Val Glu Gln Lys Phe 
  1               5                  10                  15
Gly Leu Phe Ser Ala Glu Ile Lys Glu Ala Asp Pro Leu Ala Ala Ser 
             20                  25                  30
Glu Ala Ser Gln Pro Lys Pro Cys Pro Pro Glu Val Thr Pro His Tyr 
         35                  40                  45
Ile Trp Ile Asp Phe Leu Val Gln Arg Phe Glu Ile Ala Lys Tyr Cys 
     50                  55                  60
Ser Ser Asp Gln Val Glu Ile Phe Ser Ser Leu Leu Gln Arg Ser Met 
 65                  70                  75                  80
Ser Leu Asn Ile Gly Gly Ala Lys Gly Ser Met Asn Arg His Val Ala 
                 85                  90                  95
Ala Ile Gly Pro Arg Phe Lys Leu Leu Thr Leu Gly Leu Ser Leu Leu 
             100                105                110
His Ala Asp Val Val Pro Asn Ala Thr Ile Arg Asn Val Leu Arg Glu 
         115                120                125
Lys Ile Tyr Ser Thr Ala Phe Asp Tyr Phe Ser Cys Pro Pro Lys Phe 
     130                135                140
Pro Thr Gln Gly Glu Lys Arg Leu Arg Glu Asp Ile Ser Ile Met Ile 
 145                150                155                160
Lys Phe Trp Thr Ala Met Phe Ser Asp Lys Lys Tyr Leu Thr Ala Ser 
                 165                170                175
Gln Leu Val Pro Pro Asp Asn Gln Asp Thr Arg Ser Asn Leu Asp Ile 
             180                185                190
Thr Val Gly Ser Arg Gln Gln Ala Thr Gln Gly Trp Ile Asn Thr Tyr 
         195                200                205
Pro Leu Ser Ser Gly Met Ser Thr Ile Ser Lys Lys Ser Gly Met Ser 
     210                215                220
Lys Lys Thr Asn Arg Gly Ser Gln Leu His Lys Tyr Tyr Met Lys Arg 
 225                230                235                240
Arg Thr Leu Leu Leu Ser Leu Leu Ala Thr Glu Ile Glu Arg Leu Ile 
                 245                250                255
Thr Trp Tyr Asn Pro Leu Ser Ala Pro Glu Leu Glu Leu Asp Gln Ala 
             260                265                270
Gly Glu Asn Ser Val Ala Asn Trp Arg Ser Lys Tyr Ile Ser Leu Ser 
         275                280                285
Glu Lys Gln Trp Lys Asp Asn Val Asn Leu Ala Trp Ser Ile Ser Pro 
     290                295                300
Tyr Leu Ala Val Gln Leu Pro Ala Arg Phe Lys Asn Thr Glu Ala Ile 
 305                310                315                320
Gly Asn Glu Val Thr Arg Leu Val Arg Leu Asp Pro Gly Ala Val Ser 
                 325                330                335
Asp Val Pro Glu Ala Ile Lys Phe Leu Val Thr Trp His Thr Ile Asp 
             340                345                350
Ala Asp Ala Pro Glu Leu Ser His Val Leu Cys Trp Ala Pro Thr Asp 
         355                360                365
Pro Pro Thr Gly Leu Ser Tyr Phe Ser Ser Met Tyr Pro Pro His Pro 
     370                375                380
Leu Thr Ala Gln Tyr Gly Val Lys Val Leu Arg Ser Phe Pro Pro Asp 
 385                390                395                400
Ala Ile Leu Phe Tyr Ile Pro Gln Ile Val Gln Ala Leu Arg Tyr Asp 
                 405                410                415
Lys Met Gly Tyr Val Arg Glu Tyr Ile Leu Trp Ala Ala Ser Lys Ser 
             420                425                430
Gln Leu Leu Ala His Gln Phe Ile Trp Asn Met Lys Thr Asn Ile Tyr 
         435                440                445
Leu Asp Glu Glu Gly His Gln Lys Asp Pro Asp Ile Gly Asp Leu Leu 
     450                455                460
Asp Gln Leu Val Glu Glu Ile Thr Gly Ser Leu Ser Gly Pro Ala Lys 
 465                470                475                480
Asp Phe Tyr Gln Arg Glu Phe Asp Phe Phe Asn Lys Ile Thr Asn Val 
                 485                490                495
Ser Ala Ile Ile Lys Pro Tyr Pro Lys Gly Asp Glu Arg Lys Lys Ala 
             500                505                510
Cys Leu Ser Ala Leu Ser Glu Val Lys Val Gln Pro Gly Cys Tyr Leu 
         515                520                525
Pro Ser Asn Pro Glu Ala Ile Val Leu Asp Ile Asp Tyr Lys Ser Gly 
     530                535                540
Thr Pro Met Gln Ser Ala Ala Lys Ala Pro Tyr Leu Ala Lys Phe Lys 
 545                550                555                560
Val Lys Arg Cys Gly Val Ser Glu Leu Glu Lys Glu Gly Leu Arg Cys 
                 565                570                575
Arg Ser Asp Ser Glu Asp Glu Cys Ser Thr Gln Glu Ala Asp Gly Gln 
             580                585                590
Lys Ile Ser Trp Gln Ala Ala Ile Phe Lys Val Gly Asp Asp Cys Arg 
         595                600                605
Gln Asp Met Leu Ala Leu Gln Ile Ile Asp Leu Phe Lys Asn Ile Phe 
     610                615                620
Gln Leu Val Gly Leu Asp Leu Phe Val Phe Pro Tyr Arg Val Val Ala 
 625                630                635                640
Thr Ala Pro Gly Cys Gly Val Ile Glu Cys Ile Pro Asp Cys Thr Ser 
                 645                650                655
Arg Asp Gln Leu Gly Arg Gln Thr Asp Phe Gly Met Tyr Asp Tyr Phe 
             660                665                670
Thr Arg Gln Tyr Gly Asp Glu Ser Thr Leu Ala Phe Gln Gln Ala Arg 
         675                680                685
Tyr Asn Phe Ile Arg Ser Met Ala Ala Tyr Ser Leu Leu Leu Phe Leu 
     690                695                700
Leu Gln Ile Lys Asp Arg His Asn Gly Asn Ile Met Leu Asp Lys Lys 
 705                710                715                720
Gly His Ile Ile His Ile Asp Phe Gly Phe Met Phe Glu Ser Ser Pro 
                 725                730                735
Gly Gly Asn Leu Gly Trp Glu Pro Asp Ile Lys Leu Thr Asp Glu Met 
             740                745                750
Val Met Ile Met Gly Gly Lys Met Glu Ala Thr Pro Phe Lys Trp Phe 
         755                760                765
Met Glu Met Cys Val Arg Gly Tyr Leu Ala Val Arg Pro Tyr Met Asp 
     770                775                780
Ala Val Val Ser Leu Val Thr Leu Met Leu Asp Thr Gly Leu Pro Cys 
 785                790                795                800
Phe Arg Gly Gln Thr Ile Lys Leu Leu Lys His Arg Phe Ser Pro Asn 
                 805                810                815
Met Thr Glu Arg Glu Ala Ala Asn Phe Ile Met Lys Val Ile Gln Ser 
             820                825                830
Cys Phe Leu Ser Asn Arg Ser Arg Thr Tyr Asp Met Ile Gln Tyr Tyr 
         835                840                845
Gln Asn Asp Ile Pro Tyr 
     850



<210> 2203
<211> 3123
<212> DNA
<213> Rattus norvegicus
<308> D83948
<400> 2203

ggcacgagc  cgtgccgcg  ctgagagga  gcggcactg  gtttccttg  gagggcaac  60
cgttgggcg  gtctccctt  cccctgtcc  cccttttgc  tccagtctt  gacttggta  120
ttgcatgca  tggctcccg  cgaactaac  gttctgaag  aggtagtgg  gggcggagg  180
gatgcctgg  agccctccc  tgacagccc  ggccgagaa  agtctctgc  ggaggtatc  240
cccagactg  cagatcatg  tgacagcag  aggggaggc  gagaagtga  aggagccag  300
tactgagga  gggctccag  agctcctaa  gatcctatc  ggacatgga  tatgaaaga  360
gaggtggtc  tggtgacag  actggccgg  atggagcta  tgaccgctc  caggacgat  420
gtggagaga  ccgcagccg  gaccatgat  atagagaca  ggactatcg  tcataccca  480
gagagtatg  cagtcagga  ggcaagcat  agtatgacg  ctcatctga  gagcaaagt  540
cagagatcc  tggccagct  cagtcccat  gtgtccaag  acgagaggt  cggctgatg  600
ggaacaaat  ctcaggtca  agccggggc  tcgccttcg  cgagtttag  cacttgcag  660
acgctacac  atggatgga  gccaatcag  attccctca  catcctggg  cagaaggta  720
ccatgcatt  cagcgaccc  aagcccaag  tcaatgagg  ctggctgtg  aataagtgt  780
gtgtccaga  cttcaagcg  cgagagaag  gcttcaaat  cggtgtgcc  aaatcagaa  840
cagagcaga  gctacccct  ggcactcga  tggatcagc  ggcactacc  ttgggtggg  900
gggagctaa  ccagggcct  ctcccactg  cgcagccct  ccaggccca  ggagtgctg  960
cctcgcaag  cttgtcaca  ggctcagag  caagctccg  gaatgccaa  gacaccatt  1020
ttttacgca  cctgaaccc  cacagcact  tggattcca  cctcggggc  ctagcaccc  1080
atgcggtgc  gtcctcttc  aatgttcgt  ttatcaagg  caagcagac  cagctgaac  1140
gaggcttcg  cttcatcca  ctctccacc  tcgtggaag  agcccagct  ctacagatc  1200
ttcaggccc  acaccctcc  ctcaccatc  atggcaaga  catcaacgt  gagtttgcc  1260
agggctcta  gagggatat  gcctccaat  aaggcagtc  catcaatgc  gcctctgtg  1320
ccagcactg  cattgctgc  gcccagtgg  caatctcac  ggcctccca  ggtggggag  1380
gtacctggg  tgcccccga  gagccacca  ttgactaca  ctactacca  caggatgag  1440
gctatggca  cagccaggg  acagattcc  tctatgccc  tggctacct  aagaatacc  1500
agggccctg  catgactgg  accaaaggg  acacatctg  agcaggtcc  gagacctcc  1560
ttgagggtg  gacagactc  gtgtcactg  aggctttct  tcgagccca  cctggtgct  1620
cccctggac  ctatcagca  tcagctgag  ggagcagtg  ccagggcac  gctaccaac  1680
gccagtcat  taccatcat  tcacctgct  tgctcaagt  tgagctcca  agccctact  1740
atcccagct  tgccttacc  ccggccacc  gtcccactg  cccagagtc  tacagccag  1800
accctgttc  tgatgtctc  acttaccaa  atgatgaga  atctggcta  tactatgac  1860
cccagactg  tctatacta  gatcccaac  cccagtatt  ctacaatgc  cagagtcag  1920
agtacctat  ctgggatgg  gagcggcgg  cctacatac  tgccttgga  cagtctgct  1980
atggacata  ggacacagg  gcatcatca  aggagggaa  agagaaaaa  gagaagcat  2040
agacgaaga  ggcccaaca  attgccaag  acatggagc  gtgggcccg  agtctcaac  2100
agcaaaaag  aaacttcaa  aacagcttc  agcctatta  tgctctacg  gatgatgaa  2160
ggcgggaat  agccactgc  gatgcaggc  atgccatcc  tgagaagaa  ggagcacta  2220
ctgaaagac  gcacaccag  atggatctc  caaagttgg  cagtgatga  cgccctagc  2280
cacctcgag  gctggtggc  gcctatagt  gagagagtg  cagtgagga  gagcaggag  2340
gagggggtc  tgagcggga  gaaaagctc  cagactggc  gaagctagc  tgtctgctc  2400
gccgccgcc  gtttcccag  aaggaggcg  tcatccggc  ccagcagct  tctggactc  2460
acaagcaaa  ccttgagat  catcgacgg  cccacttgt  agaaaatga  ttggaagca  2520
tagaaaaga  tgacatgga  caaatgaag  atcgagacc  tgcagctga  cgcagagag  2580
agtatggta  ccctgagcc  ccagagccc  aacggagga  gtacggtgg  atatctaca  2640
cctctgtgg  ctttgaaca  cccactcgg  atggattag  cagtgacaa  attggtagt  2700
gaatgctcc  ggccatggg  tggaaagaa  gcagtggtc  gggccgcaa  aagcagggc  2760
ttgtgacac  cattgaagc  caaacacgt  ttcgaggtt  tggcctggg  gcccgggga  2820
gttcctatg  ggtcacctc  acagaatcc  acaaggaga  actgcacaa  acaatggtg  2880
cccgcttca  tgaagccca  tgaacaact  tgaaagcag  ttctacaga  aaggggtat  2940
catccaggg  cagagaaga  gaggtctgg  atggtctga  gaaggctct  ctatctacc  3000
gcctgctgc  caaccagag  ggccctcac  aaattagac  tggagttgc  gacttttgc  3060
gggaaattg  gctcaaatc  tgtttcttt  gtaataaaa  ctaaaaagc  tgcatcttc  3120
att  3123



<210> 2204
<211> 852
<212> PRT
<213> Rattus norvegicus
<308> P70501
<400> 2204

Met Glu Tyr Glu Arg Arg Gly Gly Arg Gly Asp Arg Thr Gly Arg Tyr 
  1               5                  10                  15
Gly Ala Thr Asp Arg Ser Gln Asp Asp Gly Gly Glu Asn Arg Ser Arg 
             20                  25                  30
Asp His Asp Tyr Arg Asp Met Asp Tyr Arg Ser Tyr Pro Arg Glu Tyr 
         35                  40                  45
Gly Ser Gln Glu Gly Lys His Glu Tyr Asp Asp Ser Ser Glu Glu Gln 
     50                  55                  60
Ser Ala Glu Ile Arg Gly Gln Leu Gln Ser His Gly Val Gln Ala Arg 
 65                  70                  75                  80
Glu Val Arg Leu Met Arg Asn Lys Ser Ser Gly Gln Ser Arg Gly Phe 
                 85                  90                  95
Ala Phe Val Glu Phe Ser His Leu Gln Asp Ala Thr Arg Trp Met Glu 
             100                105                110
Ala Asn Gln His Ser Leu Asn Ile Leu Gly Gln Lys Val Ser Met His 
         115                120                125
Tyr Ser Asp Pro Lys Pro Lys Ile Asn Glu Asp Trp Leu Cys Asn Lys 
     130                135                140
Cys Gly Val Gln Asn Phe Lys Arg Arg Glu Lys Cys Phe Lys Cys Gly 
 145                150                155                160
Val Pro Lys Ser Glu Ala Glu Gln Lys Leu Pro Leu Gly Thr Arg Leu 
                 165                170                175
Asp Gln Gln Ala Leu Pro Leu Gly Gly Arg Glu Leu Ser Gln Gly Leu 
             180                185                190
Leu Pro Leu Pro Gln Pro Tyr Gln Ala Gln Gly Val Leu Thr Ser Gln 
         195                200                205
Ala Leu Ser Gln Gly Ser Glu Pro Ser Ser Glu Asn Ala Asn Asp Thr 
     210                215                220
Ile Ile Leu Arg Asn Leu Asn Pro His Ser Thr Met Asp Ser Ile Leu 
 225                230                235                240
Gly Ala Leu Ala Pro Tyr Ala Val Leu Ser Ser Ser Asn Val Arg Val 
                 245                250                255
Ile Lys Asp Lys Gln Thr Gln Leu Asn Arg Gly Phe Ala Phe Ile Gln 
             260                265                270
Leu Ser Thr Ile Val Glu Ala Ala Gln Leu Leu Gln Ile Leu Gln Ala 
         275                280                285
Leu His Pro Pro Leu Thr Ile Asp Gly Lys Thr Ile Asn Val Glu Phe 
     290                295                300
Ala Lys Gly Ser Lys Arg Asp Met Ala Ser Asn Glu Gly Ser Arg Ile 
 305                310                315                320
Asn Ala Ala Ser Val Ala Ser Thr Ala Ile Ala Ala Ala Gln Trp Ala 
                 325                330                335
Ile Ser Gln Ala Ser Gln Gly Gly Glu Ser Thr Trp Ala Ala Pro Glu 
             340                345                350
Glu Pro Pro Val Asp Tyr Ser Tyr Tyr Gln Gln Asp Glu Gly Tyr Gly 
         355                360                365
Ser Ser Gln Gly Thr Asp Ser Leu Tyr Ala His Gly Tyr Leu Lys Asn 
     370                375                380
Thr Lys Gly Pro Gly Met Thr Gly Thr Lys Gly Asp Thr Ser Gly Ala 
 385                390                395                400
Gly Pro Glu Thr Ser Leu Glu Gly Gly Thr Asp Ser Val Ser Leu Gln 
                 405                410                415
Ala Phe Ser Arg Ala Gln Pro Gly Ala Ala Pro Gly Leu Tyr Gln Gln 
             420                425                430
Ser Ala Glu Gly Ser Ser Gly Gln Gly Thr Ala Thr Asn Ser Gln Ser 
         435                440                445
Tyr Thr Ile Met Ser Pro Ala Val Leu Lys Ser Glu Leu Gln Ser Pro 
     450                455                460
Thr His Pro Ser Ser Ala Leu Pro Pro Ala Thr Ser Pro Thr Ala Pro 
 465                470                475                480
Glu Ser Tyr Ser Gln Tyr Pro Val Pro Asp Val Ser Thr Tyr Gln Tyr 
                 485                490                495
Asp Glu Thr Ser Gly Tyr Tyr Tyr Asp Pro Gln Thr Gly Leu Tyr Tyr 
             500                505                510
Asp Pro Asn Ser Gln Tyr Tyr Tyr Asn Ala Gln Ser Gln Gln Tyr Leu 
         515                520                525
Tyr Trp Asp Gly Glu Arg Arg Thr Tyr Ile Pro Ala Leu Glu Gln Ser 
     530                535                540
Ala Asp Gly His Lys Asp Thr Gly Ala Ser Ser Lys Glu Gly Lys Glu 
 545                550                555                560
Lys Lys Glu Lys His Lys Thr Lys Thr Ala Gln Gln Ile Ala Lys Asp 
                 565                570                575
Met Glu Arg Trp Ala Arg Ser Leu Asn Lys Gln Lys Glu Asn Phe Lys 
             580                585                590
Asn Ser Phe Gln Pro Ile Ser Ala Leu Arg Asp Asp Glu Arg Arg Glu 
         595                600                605
Ser Ala Thr Ala Asp Ala Gly Tyr Ala Ile Leu Glu Lys Lys Gly Ala 
     610                615                620
Leu Ala Glu Arg Gln His Thr Ser Met Asp Leu Pro Lys Leu Ala Ser 
 625                630                635                640
Asp Asp Arg Pro Ser Pro Pro Arg Gly Leu Val Ala Ala Tyr Ser Gly 
                 645                650                655
Glu Ser Asp Ser Glu Glu Glu Gln Glu Arg Gly Gly Pro Glu Arg Glu 
             660                665                670
Glu Lys Leu Thr Asp Trp Gln Lys Leu Ala Cys Leu Leu Cys Arg Arg 
         675                680                685
Gln Phe Pro Ser Lys Glu Ala Leu Ile Arg His Gln Gln Leu Ser Gly 
     690                695                700
Leu His Lys Gln Asn Leu Glu Ile His Arg Arg Ala His Leu Ser Glu 
 705                710                715                720
Asn Glu Leu Glu Ala Leu Glu Lys Asn Asp Met Glu Gln Met Lys Tyr 
                 725                730                735
Arg Asp Arg Ala Ala Glu Arg Arg Glu Lys Tyr Gly Ile Pro Glu Pro 
             740                745                750
Pro Glu Pro Lys Arg Arg Lys Tyr Gly Gly Ile Ser Thr Ala Ser Val 
         755                760                765
Asp Phe Glu Gln Pro Thr Arg Asp Gly Leu Gly Ser Asp Asn Ile Gly 
     770                775                780
Ser Arg Met Leu Gln Ala Met Gly Trp Lys Glu Gly Ser Gly Leu Gly 
 785                790                795                800
Arg Lys Lys Gln Gly Ile Val Thr Pro Ile Glu Ala Gln Thr Arg Val 
                 805                810                815
Arg Gly Ser Gly Leu Gly Ala Arg Gly Ser Ser Tyr Gly Val Thr Ser 
             820                825                830
Thr Glu Ser Tyr Lys Glu Thr Leu His Lys Thr Met Val Thr Arg Phe 
         835                840                845
Asn Glu Ala Gln 
     850



<210> 2205
<211> 1451
<212> DNA
<213> Homo sapiens
<308> AK000962
<400> 2205

tcccttctc  tcgtcgcca  tttgagctg  tgactgtgg  cggctggga  taggcggca  60
tgagtttcc  tgggagggc  gcgcgcttg  cgcttctcc  ctccccccg  tctgcctcc  120
gtctcggac  tggttgttg  gcgctccgg  tccggctga  ctgggagag  tggaggagg  180
ggcggcggg  agaggtgat  tctgggagc  cttccttga  agcccgggc  gagaagagt  240
cctgcggga  gcatcaccc  ggctggcag  tcatggtag  agcagcggg  gtggctggg  300
agtgaaacg  agccagcgg  tgaggaggg  ccccagcag  ccccgaagg  cctatcagg  360
catggagta  gaaagacgt  gtggttgtg  tgacaggac  ggccgctat  gagccactg  420
ccgctcgca  gatgatggt  gggagaacc  cagccgaga  cacgactac  gggacatgg  480
ctaccgttc  tatcctcgc  agtatggca  ccaggaggg  aagcatgac  atgacgact  540
atctgagga  cagagtgcg  aggattcct  cgaggcctc  ccgggctcc  agactcagc  600
taggcggcg  cggcggcac  ggcttcccc  gagacggcg  ctatcggga  caggactat  660
ggaccgagc  aggggagga  gaggaggag  aggaggatg  ggaggagga  gagaaggcc  720
gtaacatcg  catgctgag  atgctgcca  aggcagcca  tgaggatga  atccgtggc  780
agctgcagt  gcacggcgt  caagcacgg  aggttcggc  gatgcggaa  aaatcttca  840
cactccctc  acatcctgg  ccagaaggt  tcgatgcac  acagtgacc  caagcccaa  900
atcaatgag  actggctgt  caataagtg  ggcgtccag  gcccaagag  aggaagtac  960
gcggcatat  cacagcctc  gtagacttc  agcagccta  tcgggacgg  ctgggcagt  1020
acaacattg  cagtcggat  ctgcaggcc  tgggctgga  agagggcag  ggcctgggc  1080
gcaagaagc  gggcattgt  acgcctatc  aggcccaaa  acgggtgcg  ggctccggc  1140
tgggtgcac  gggcagctc  tacggggtc  cctcaaccg  gtcctacaa  gagacactg  1200
acaagacaa  ggtgacccg  ttcaacgag  cccagtgag  agcttcaag  gcaacttct  1260
cacatgttg  gtgtccatc  tggggcagg  caggacaga  tgttggatg  ctgggacgg  1320
gccttgctc  tgtcggcca  cccactccc  agccagaga  ggcttgacc  aatcaaatt  1380
aggtggtga  ttttgttgg  aaattgggc  gggatcacg  cctgttttg  aataaaagc  1440
gaaaagtct  c  1451



<210> 2206
<211> 173
<212> PRT
<213> Homo sapiens
<308> AK000962
<400> 2206

Met Lys Asp Val Val Val Val Val Thr Gly Leu Ala Ala Met Glu Pro 
  1               5                  10                  15
Leu Thr Ala Arg Arg Met Met Val Gly Arg Thr Ala Ala Glu Thr Thr 
             20                  25                  30
Thr Thr Gly Thr Trp Thr Thr Val His Ile Leu Ala Ser Met Ala Ala 
         35                  40                  45
Arg Arg Ala Ser Met Thr Met Thr Thr His Leu Arg Ser Arg Val Arg 
     50                  55                  60
Arg Ile Pro Thr Arg Pro Pro Arg Ala Pro Arg Leu Ser Val Gly Gly 
 65                  70                  75                  80
Gly Gly Gly Thr Gly Phe Pro Arg Asp Gly Asp Tyr Arg Asp Gln Asp 
                 85                  90                  95
Tyr Arg Thr Glu Gln Gly Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu 
             100                105                110
Glu Glu Glu Lys Ala Ser Asn Ile Val Met Leu Arg Met Leu Pro Gln 
         115                120                125
Ala Ala Thr Glu Asp Asp Ile Arg Gly Gln Leu Gln Ser His Gly Val 
     130                135                140
Gln Ala Arg Glu Val Arg Leu Met Arg Asn Lys Ser Ser Ala Leu Pro 
 145                150                155                160
Gln His Pro Gly Pro Glu Gly Val Asp Ala Leu Gln Ter 
                 165                170



<210> 2207
<211> 3387
<212> DNA
<213> Rattus norvegicus
<308> D84346
<400> 2207

atgtcgcgc  ccgtgctgc  gcccagtca  cagaagctg  cggagaagc  caccatcct  60
aacgaccgg  gcgtcggca  gctcacgcg  ctctacaac  tcaagaagg  atgtggaga  120
cccaaggct  aaccatcct  ccttattga  aaaaacctg  aatctgctg  gaaattcat  180
gtcagaaaa  ttcctgctg  agaaacacg  aacaacaat  aacagcttg  acaactaca  240
aaagaaaaa  cagagattc  gaaaaatct  gcattatat  actttacat  tgtagatgt  300
atggaattt  aggaccatg  ctgtgactt  ctgaatact  tcgacgtct  ccaagtctt  360
tttgatatt  ctgtgaact  tgatttaac  aagaactac  tagacttga  tgtgaccta  420
acaacatta  tgatactgc  gtcccggat  gaagaaagg  aggccatca  tggactgta  480
aattatgca  atgaaatga  ccacggagc  agtgaccga  aatacccac  ccttggtca  540
atgattgtg  actatgaac  ccctttaaa  aagatgatg  aagaattcg  accccacag  600
aagtctctt  cagatgcgc  aatttctct  cagatggtg  atcctagac  gaatctttc  660
gcagatcag  ggaggaatg  ccagttgtt  agtctcatc  gtgcaccca  tacaatgct  720
aatcctgca  agtctgaca  catgccttg  gaatatctc  ctttggatg  aatggagaa  780
tggattatc  ttggcttta  tctgtgcca  gggatgcta  ataccgagg  tacagcact  840
aacctttgg  agctagctc  tcagagtag  tcctgcctc  ctctctttc  ggatgaagt  900
ttccacatt  acaaagctg  agaagattt  tttgtaaac  ttcggggct  taataaacg  960
attaacgac  taagagaat  taaggaggc  gctgtatcc  acgctggct  aatgcacag  1020
gagagacgc  agtttttac  gtctgcact  aaagaactg  caactgtcc  ctcggatca  1080
cctggcctg  ttggtccca  ggcactttt  gttttcatg  cattatctt  tgcccgtga  1140
gaaattatc  ggctactcc  tcatgcaga  aacatgcca  agaagagtg  agatgactt  1200
atagataag  acattgctg  gctgatctt  tacatggag  agctcagag  acatgtcag  1260
aagtacggg  ctgtcatgc  gaggtacta  gtgcagtac  tctccggct  cgatgctgt  1320
gtccttaac  agcttgtgc  gaatctctc  gtttgccct  aagatgaat  aatcatcat  1380
tcctccttt  ttaacacca  gacttccct  agtgtgaaa  aagttgaag  tggggaagt  1440
tttgatttc  gaggaatga  attagattg  tttaggtta  aggcataca  tagtgtctc  1500
aaagcttca  ttagccttg  agatcaccg  gaactcgga  agatgatga  cacaataat  1560
ttccataca  agatggtcg  ttccttggt  gaaatgttg  tggaaacat  cgatctctc  1620
atattttgt  tttatagcc  tgcttttga  aagatgttt  agcagtgct  ggagttgcc  1680
tctcagtcg  gatactcca  cgcctttcc  ctgctctgc  ctcacttca  gagctgcac  1740
catgagctg  gtcccgaag  gcgccatca  ataggggat  gtagccttt  cctgtgtaa  1800
atgttcctt  atgagatgg  caaacaagc  cggaacctc  tcactgata  ttgcacaga  1860
cagtgtact  ttagtgacc  gttactgcc  aagcattgt  ccaaaacca  cagtcaagc  1920
gtgaataag  agtcaaaaa  acagactgg  aagaaaggg  aacctgaaa  ggaaaagcc  1980
ggtgtcgag  gcatgagga  aaacaggct  gtagtgacc  accttgata  gttgcacac  2040
gcactttcg  agttatgct  ctccataaa  tatgttcca  acatggcag  gtgggaaca  2100
accttcaca  cgcgggagt  cttgacttc  catctggaa  tccgattca  taaatcaat  2160
gttggaatg  ccatgtata  tcaggctac  caggagatt  caaagccat  agaacttct  2220
acaagcgta  gagaatata  gactgtact  cagtccata  agaactatg  gcagattga  2280
atcaccaga  tatttaata  tgtccttct  cagcaaaca  aacacttag  cagccatgg  2340
gaaccaacc  tcacgagtc  gtatacaaa  tggtacttg  aaacgttat  aagacaagt  2400
agcaatggc  atatagctt  ttttcctgc  atgaaagca  ttgtgaatt  acccacaga  2460
aatgaatta  cattcaatg  agaggaata  tctgatata  cagaaatga  gtcgttgtc  2520
gagctctta  gcccatatg  gatgaagtt  ctaagcgag  gtcttatgt  gcatatttc  2580
tcacaagtt  ctgaactta  gaaacttgt  gtggagaat  ttgatgttc  aacacaaat  2640
aggaccagc  ttgacaaac  agaccagat  gctgcactc  ttaaaagat  atcatctgt  2700
gacagtgtc  tgaaaagga  gacgataat  ggtgttatt  tatccttcc  gtcactggc  2760
caagaagca  tgagagatg  tttgtccta  cacattcct  ttctcgtga  ctccattga  2820
gatttcaag  accacattc  acgggaaac  gatatgaag  ttgcaatga  tgtgtatga  2880
ctgtcatct  ctgctggat  accatgcga  attgatcct  ccttagtag  agctctttc  2940
tcacaaaaa  cagagaaca  tagtccaga  gaagaatat  agatcgctt  cctcctgat  3000
gtctttgta  cagtttccc  gcctacact  gccagcaat  tgatgtccc  gtacagccc  3060
gcaatagaa  gacactgca  caatattca  tgtctggcc  aagcaatca  ccaaattgc  3120
gctgctttg  ttacaattc  caaaggaag  attgaagac  gacttaaag  attcctggc  3180
cttgcgtcc  ccagtctac  gaaaatcgg  caagagaca  ataaaacta  aacgagaaa  3240
agagaatct  tttatttgc  actggatat  attgtacaa  aatcaccgt  cctgacaat  3300
gatctcttg  aatcttgtt  tccttatgt  ttgctgaga  atgcatacc  cgctgtcta  3360
aaacaaagt  tcacatcct  tgcatag  3387



<210> 2208
<211> 1128
<212> PRT
<213> Rattus norvegicus
<308> P55161
<400> 2208

Met Ser Arg Ser Val Leu Gln Pro Ser Gln Gln Lys Leu Ala Glu Lys 
  1               5                  10                  15
Leu Thr Ile Leu Asn Asp Arg Gly Val Gly Met Leu Thr Arg Leu Tyr 
             20                  25                  30
Asn Ile Lys Lys Ala Cys Gly Asp Pro Lys Ala Lys Pro Ser Tyr Leu 
         35                  40                  45
Ile Asp Lys Asn Leu Glu Ser Ala Val Lys Phe Ile Val Arg Lys Phe 
     50                  55                  60
Pro Ala Val Glu Thr Arg Asn Asn Asn Gln Gln Leu Ala Gln Leu Gln 
 65                  70                  75                  80
Lys Glu Lys Ser Glu Ile Leu Lys Asn Leu Ala Leu Tyr Tyr Phe Thr 
                 85                  90                  95
Phe Val Asp Val Met Glu Phe Lys Asp His Val Cys Asp Leu Leu Asn 
             100                105                110
Thr Ile Asp Val Cys Gln Val Phe Phe Asp Ile Thr Val Asn Phe Asp 
         115                120                125
Leu Thr Lys Asn Tyr Leu Asp Leu Thr Val Thr Tyr Thr Thr Leu Met 
     130                135                140
Ile Leu Leu Ser Arg Ile Glu Glu Arg Lys Ala Ile Ile Gly Leu Tyr 
 145                150                155                160
Asn Tyr Ala His Glu Met Thr His Gly Ala Ser Asp Arg Glu Tyr Pro 
                 165                170                175
Arg Leu Gly Gln Met Ile Val Asp Tyr Glu His Pro Leu Lys Lys Met 
             180                185                190
Met Glu Glu Phe Val Pro His Ser Lys Ser Leu Ser Asp Ala Leu Ile 
         195                200                205
Ser Leu Gln Met Val Tyr Pro Arg Arg Asn Leu Ser Ala Asp Gln Trp 
     210                215                220
Arg Asn Ala Gln Leu Leu Ser Leu Ile Ser Ala Pro Ser Thr Met Leu 
 225                230                235                240
Asn Pro Ala Gln Ser Asp Thr Met Pro Cys Glu Tyr Leu Ser Leu Asp 
                 245                250                255
Ala Met Glu Lys Trp Ile Ile Phe Gly Phe Ile Leu Cys His Gly Met 
             260                265                270
Leu Asn Thr Glu Ala Thr Ala Leu Asn Leu Trp Lys Leu Ala Leu Gln 
         275                280                285
Ser Ser Ser Cys Leu Ser Leu Phe Arg Asp Glu Val Phe His Ile His 
     290                295                300
Lys Ala Ala Glu Asp Leu Phe Val Asn Ile Arg Gly Tyr Asn Lys Arg 
 305                310                315                320
Ile Asn Asp Ile Arg Glu Cys Lys Glu Ala Ala Val Ser His Ala Gly 
                 325                330                335
Ser Met His Arg Glu Arg Arg Lys Phe Leu Arg Ser Ala Leu Lys Glu 
             340                345                350
Leu Ala Thr Val Leu Ser Asp Gln Pro Gly Leu Leu Gly Pro Lys Ala 
         355                360                365
Leu Phe Val Phe Met Ala Leu Ser Phe Ala Arg Asp Glu Ile Ile Trp 
     370                375                380
Leu Leu Arg His Ala Asp Asn Met Pro Lys Lys Ser Ala Asp Asp Phe 
 385                390                395                400
Ile Asp Lys His Ile Ala Glu Leu Ile Phe Tyr Met Glu Glu Leu Arg 
                 405                410                415
Ala His Val Arg Lys Tyr Gly Pro Val Met Gln Arg Tyr Tyr Val Gln 
             420                425                430
Tyr Leu Ser Gly Phe Asp Ala Val Val Leu Asn Glu Leu Val Gln Asn 
         435                440                445
Leu Ser Val Cys Pro Glu Asp Glu Ser Ile Ile Met Ser Ser Phe Val 
     450                455                460
Asn Thr Met Thr Ser Leu Ser Val Lys Gln Val Glu Asp Gly Glu Val 
 465                470                475                480
Phe Asp Phe Arg Gly Met Arg Leu Asp Trp Phe Arg Leu Gln Ala Tyr 
                 485                490                495
Thr Ser Val Ser Lys Ala Ser Leu Ser Leu Ala Asp His Arg Glu Leu 
             500                505                510
Gly Lys Met Met Asn Thr Ile Ile Phe His Thr Lys Met Val Asp Ser 
         515                520                525
Leu Val Glu Met Leu Val Glu Thr Ser Asp Leu Ser Ile Phe Cys Phe 
     530                535                540
Tyr Ser Arg Ala Phe Glu Lys Met Phe Gln Gln Cys Leu Glu Leu Pro 
 545                550                555                560
Ser Gln Ser Arg Tyr Ser Ile Ala Phe Pro Leu Leu Cys Thr His Phe 
                 565                570                575
Met Ser Cys Thr His Glu Leu Cys Pro Glu Glu Arg His His Ile Gly 
             580                585                590
Asp Arg Ser Leu Ser Leu Cys Asn Met Phe Leu Asp Glu Met Ala Lys 
         595                600                605
Gln Ala Arg Asn Leu Ile Thr Asp Ile Cys Thr Glu Gln Cys Thr Leu 
     610                615                620
Ser Asp Gln Leu Leu Pro Lys His Cys Ala Lys Thr Ile Ser Gln Ala 
 625                630                635                640
Val Asn Lys Lys Ser Lys Lys Gln Thr Gly Lys Lys Gly Glu Pro Glu 
                 645                650                655
Arg Glu Lys Pro Gly Val Glu Ser Met Arg Lys Asn Arg Leu Val Val 
             660                665                670
Thr Asn Leu Asp Lys Leu His Thr Ala Leu Ser Glu Leu Cys Phe Ser 
         675                680                685
Ile Asn Tyr Val Pro Asn Met Ala Val Trp Glu His Thr Phe Thr Pro 
     690                695                700
Arg Glu Tyr Leu Thr Ser His Leu Glu Ile Arg Phe Thr Lys Ser Ile 
 705                710                715                720
Val Gly Met Thr Met Tyr Asn Gln Ala Thr Gln Glu Ile Ala Lys Pro 
                 725                730                735
Ser Glu Leu Leu Thr Ser Val Arg Glu Tyr Met Thr Val Leu Gln Ser 
             740                745                750
Ile Glu Asn Tyr Val Gln Ile Asp Ile Thr Arg Val Phe Asn Asn Val 
         755                760                765
Leu Leu Gln Gln Thr Gln His Leu Asp Ser His Gly Glu Pro Thr Ile 
     770                775                780
Thr Ser Leu Tyr Thr Asn Trp Tyr Leu Glu Thr Leu Leu Arg Gln Val 
 785                790                795                800
Ser Asn Gly His Ile Ala Tyr Phe Pro Ala Met Lys Ala Phe Val Asn 
                 805                810                815
Leu Pro Thr Glu Asn Glu Leu Thr Phe Asn Ala Glu Glu Tyr Ser Asp 
             820                825                830
Ile Ser Glu Met Arg Ser Leu Ser Glu Leu Leu Gly Pro Tyr Gly Met 
         835                840                845
Lys Phe Leu Ser Glu Ser Leu Met Trp His Ile Ser Ser Gln Val Ala 
     850                855                860
Glu Leu Lys Lys Leu Val Val Glu Asn Val Asp Val Leu Thr Gln Met 
 865                870                875                880
Arg Thr Ser Phe Asp Lys Pro Asp Gln Met Ala Ala Leu Phe Lys Arg 
                 885                890                895
Leu Ser Ser Val Asp Ser Val Leu Lys Arg Met Thr Ile Ile Gly Val 
             900                905                910
Ile Leu Ser Phe Arg Ser Leu Ala Gln Glu Ala Leu Arg Asp Val Leu 
         915                920                925
Ser Tyr His Ile Pro Phe Leu Val Ser Ser Ile Glu Asp Phe Lys Asp 
     930                935                940
His Ile Pro Arg Glu Thr Asp Met Lys Val Ala Met Asn Val Tyr Glu 
 945                950                955                960
Leu Ser Ser Ala Ala Gly Leu Pro Cys Glu Ile Asp Pro Ala Leu Val 
                 965                970                975
Val Ala Leu Ser Ser Gln Lys Ser Glu Asn Ile Ser Pro Glu Glu Glu 
             980                985                990
Tyr Lys Ile Ala Cys Leu Leu Met Val Phe Val Ala Val Ser Leu Pro 
         995                1000                1005
Thr Leu Ala Ser Asn Val Met Ser Gln Tyr Ser Pro Ala Ile Glu Gly 
     1010                1015                1020
His Cys Asn Asn Ile His Cys Leu Ala Lys Ala Ile Asn Gln Ile Ala 
 1025                1030                1035                1040
Ala Ala Leu Phe Thr Ile His Lys Gly Ser Ile Glu Asp Arg Leu Lys 
                 1045                1050                1055
Glu Phe Leu Ala Leu Ala Ser Ser Ser Leu Leu Lys Ile Gly Gln Glu 
             1060                1065                1070
Thr Asp Lys Thr Thr Thr Arg Asn Arg Glu Ser Val Tyr Leu Leu Leu 
         1075                1080                1085
Asp Met Ile Val Gln Glu Ser Pro Phe Leu Thr Met Asp Leu Leu Glu 
     1090                1095                1100
Ser Cys Phe Pro Tyr Val Leu Leu Arg Asn Ala Tyr His Ala Val Tyr 
 1105                1110                1115                1120
Lys Gln Ser Val Thr Ser Ser Ala 
                 1125



<210> 2209
<211> 4982
<212> DNA
<213> Homo sapiens
<308> AB011159
<400> 2209

gcggcgagc  cctgtcaag  agtgggagg  aaaagcgct  ggagccacc  gcccactct  60
aagcgaaac  cgcctggaa  acaccccgc  tcccagcag  gtttctgcc  gtttcttta  120
aagggtggt  cggaaaagc  acttttggg  acttgaagg  gtggggtgt  gggcgaagt  180
gaaagagca  acaacgcga  cccactcag  ccccgcttg  gactcccat  ccggcatca  240
gcgtagtgg  cggtccggg  cagggccag  gccagagcg  cggcggcga  gccatgccg  300
gggcccgtc  gccgcagtt  cccgtccgg  ctcgcgggg  cgccggcgc  gccgatcag  360
tgaccgagg  cccgttcgg  gctgcggga  gcggcctcg  tctcagccg  cggagacgc  420
gccgccgcc  ccgccgccg  cacacctag  ggagcagcc  gggaaggcg  ctcgttggg  480
gctggggcg  agagcgccg  gggtggggg  ggaagggcg  cgggcggaa  gcaggaggc  540
gccggggcg  gggctgctg  gggagaagg  gctccgagg  gtccgccgc  gctcgctct  600
tcgccggcg  gggattggg  cgcgagggc  atgggcgcg  tctcctaag  cggaggtcg  660
gggcgggag  ggaggaggc  cgagagagg  tgctgcgaa  gccgcgggc  cgtgactgg  720
cgcgaggcg  ccggcggcg  cggcggcac  agcaccacc  tgtcgcgct  agtgctgca  780
cccagtcag  agaagctgg  ggagaagct  accatcctc  acgaccggg  cgtcggcat  840
ctcacccgc  tctacaaca  caagaagca  ggacaagtt  ggaaggcat  tggagaccc  900
aaggcaaaa  catcctatc  tatcgacaa  aacctggaa  ctgctgtga  attcatagt  960
agaaaattc  ctgctgtag  aacccgcaa  aacaatcaa  agcttgcac  actacagaa  1020
gaaaaatca  agattctga  aaatctggc  ttatattac  tcacatttg  agatgttat  1080
gaatttaag  accatgttt  tgaattgct  aatactatt  acgtttgcc  agtcttctt  1140
gatattact  taaactttg  tttaacaaa  aactactta  atttaatta  aacctatac  1200
acactaatg  tactgctgt  tcgaattga  gaaaggaag  caatcattg  attatacaa  1260
tatgcccat  aaatgactc  tggagcaag  gacagagaa  acccacgcc  tggccagat  1320
attgtggat  atgaaaacc  tttaaagaa  atgatggaa  aatttgtac  ccatagcaa  1380
tctctttca  atgcactaa  ttctcttca  atggtatat  ctcgaagga  tctttcagc  1440
gaccagtgg  gaaatgccc  gttattgag  ctcatcagt  cacctagta  aatgcttaa  1500
ccagcacag  ccgacacta  gccttgtga  tacctctct  tggatgcaa  ggaaaagtg  1560
attatcttt  gctttattt  gtgccatgg  atcctaaat  ctgacgcta  agcactgaa  1620
ctttggaaa  tagctcttc  aagtagctc  tgcctctct  tctttcggg  tgaagtttt  1680
cacattcac  aagctgcag  agacttatt  gtaaacata  gaggctata  taaacgtat  1740
aatgacata  gagaatgca  ggaggcagc  gtgtcacat  ctggttcaa  gcacagaga  1800
agacgcaag  ttttaagat  tgcactgaa  gaattggct  ctgtcctct  tgatcaacc  1860
ggattgcta  gtcccaagg  actttttgt  tttatggca  tatcctttg  ccgtgatga  1920
atcatctgg  tacttcgtc  tgcagataa  atgccaaag  agagtgcag  cgactttat  1980
gataagcac  ttgctgaat  aatatttta  atggaagaa  ttagagcac  tgtgaggaa  2040
tacggacct  taatgcaga  gtattacgt  cagtacctt  ctggctttg  tgctgttgt  2100
ctcaatgaa  tcgtgcaga  tctttctgt  tgccctgaa  atgaatcaa  catcatgtc  2160
tcttttgtt  acactatga  ttccctaag  gtaaaacaa  ttgaagatg  ggaagtatt  2220
gatttcaga  gaatgagat  agattggtt  aggttacag  catatacta  tgtctcaaa  2280
gcttcactt  gccttgcag  tcacagaga  cttggaaag  tgatgaata  aataatttt  2340
catacaaaa  tggtagatt  cttggtgga  atgttggtg  aaacatcag  tctctccat  2400
ttttgtttt  atagtcgtg  ttttgagaa  atgtttcaa  agtgtttgg  gttaccctc  2460
caatcaaga  actcaattg  atttccact  ctttgcact  attttatga  ttgcacgca  2520
gaactatgt  cagaagagc  acatcatat  ggagatcgc  gtctttcct  atgtaatat  2580
ttcctagat  aaatggcca  acaagctcg  aatctcatc  ctgatattt  cacagaaca  2640
tgtaccctt  gtgaccagt  gctacccaa  cattgtgcc  aaactatca  tcaagcagt  2700
aataagaaa  caaaaaagc  gactggtaa  aaaggggaa  ctgaaaggg  gaaaccagg  2760
gttgagagc  tgaggaaaa  caggctggt  gtgaccaac  ttgataaat  gcacactgc  2820
ctttctgag  tatgcttct  tataaatta  gtaccaaac  tggtggtat  ggaacatac  2880
tttacccca  gagaatatt  gacttctca  ctggaaata  gctttacca  gtcaattgt  2940
gggatgact  tgtataatc  agccacaca  gaaattgca  aaccttcag  acttctaac  3000
agtgtaaga  catacatga  cgtactcca  tcaatagaa  actatgtgc  gattgatat  3060
acaagagta  ttaataatg  gcttcttca  caaacacaa  atttagaca  tcatggaga  3120
ccaaccatt  caagtctat  cacaaattg  tatttggaa  ctttgttac  acaagtcag  3180
aatggccat  tagcatatt  tcctgcaat  aaagcgttt  tgaacttac  tacagaaaa  3240
gaattaaca  tcaatgcag  ggaatattc  gacatatca  aaatgaggt  attatcaga  3300
ctactaggc  catatggta  gaagtttct  agtgaaagc  ttatgtggc  tatttcatc  3360
caagttgct  aacttaaga  acttgtggt  gagaatgtt  atgtgttaa  acaaatgag  3420
accagcttt  acaaaccag  ccagatggc  gcactgttt  aaagattat  atctgttga  3480
agtgtcttg  agaggatga  aataattgg  gtaatttta  ccttccgat  attggcaca  3540
gaagcactt  gagatgtgt  atcctacca  attcctttt  ttgtaagtt  aattgaaga  3600
tttaaggat  acattccaa  ggaaactga  atgaaggtt  caatgaatg  gtatgagtt  3660
tcatcagct  ccggattac  ttgtgagat  gatcctgca  tggtcgtag  tctttcttc  3720
caaaaatcg  aaaacatta  tccagaaga  gagtataaa  ttgcctgcc  tctcatggt  3780
tttgtggca  tttctttgc  aacactggc  agtaatgtg  tgtctcagt  cagccctgc  3840
atagaaggg  attgcaaca  catacattg  ttggccaaa  ccatcaacc  gattgctgc  3900
gctttgttt  caattcaca  aggaagcat  gaagaccgt  ttaaagaat  tctggcgct  3960
gcatcctcc  gtctactga  aattggcca  gagacagat  aaactacaa  aagaaatag  4020
gaatctgtt  atttactgc  agatatgat  gtacaagaa  ctccattcc  tacaatgga  4080
cttttggaa  cttgttttc  ttatgtctt  ctgagaaat  cataccatg  tgtctacaa  4140
caaagtgtt  catcttctg  ataaaatta  ctacttaat  aagataagc  cgcattttt  4200
ttgccttgg  tttacctgt  gactgtgga  ctattttac  ttaagacct  aaaaagttt  4260
gtggattat  aatttcttt  atacggttg  attttctga  cattggttt  ttaatatgg  4320
tgtactaca  tatacttgg  tgatttagg  tgcacattc  ctgaattca  tgagattat  4380
cctataatt  taaagtatc  tttatttga  aaacataca  tatcaacat  tttttgata  4440
ttgataatg  aaaaaatct  tgcttgttt  tttctgaaa  agaactgta  ttagtgatt  4500
ttttagata  tgatattat  gcattcatc  gtgtgtaaa  tatttcata  agggaagag  4560
tctgatctg  acctatggt  cttattgaa  acaacattg  atgtgcatt  ctgtgatgt  4620
atgaataca  ttctacttt  ttttgaaac  tttgccaaa  taaatactg  aacactgta  4680
aacatttaa  aatgttaaa  aactgctta  tattagaag  agatcattt  ccaaaattc  4740
aagagcagc  gcatatgtt  ttgcttgta  aaagcctag  gataatttt  agactaact  4800
ccatggtgc  ctgttggca  tagcactac  attgtaccc  gctgtataa  aaacaatct  4860
agacattta  caactgttg  tacaaatgt  agtccctaa  cacttttta  atatgtttt  4920
aatttttga  attcaagtg  accttccat  acataaaat  aacactaga  tgtatcaca  4980
tt  4982



<210> 2210
<211> 1128
<212> PRT
<213> Homo sapiens
<308> Q9Y2A7
<400> 2210

Met Ser Arg Ser Val Leu Gln Pro Ser Gln Gln Lys Leu Ala Glu Lys 
  1               5                  10                  15
Leu Thr Ile Leu Asn Asp Arg Gly Val Gly Met Leu Thr Arg Leu Tyr 
             20                  25                  30
Asn Ile Lys Lys Ala Cys Gly Asp Pro Lys Ala Lys Pro Ser Tyr Leu 
         35                  40                  45
Ile Asp Lys Asn Leu Glu Ser Ala Val Lys Phe Ile Val Arg Lys Phe 
     50                  55                  60
Pro Ala Val Glu Thr Arg Asn Asn Asn Gln Gln Leu Ala Gln Leu Gln 
 65                  70                  75                  80
Lys Glu Lys Ser Glu Ile Leu Lys Asn Leu Ala Leu Tyr Tyr Phe Thr 
                 85                  90                  95
Phe Val Asp Val Met Glu Phe Lys Asp His Val Cys Glu Leu Leu Asn 
             100                105                110
Thr Ile Asp Val Cys Gln Val Phe Phe Asp Ile Thr Val Asn Phe Asp 
         115                120                125
Leu Thr Lys Asn Tyr Leu Asp Leu Ile Ile Thr Tyr Thr Thr Leu Met 
     130                135                140
Ile Leu Leu Ser Arg Ile Glu Glu Arg Lys Ala Ile Ile Gly Leu Tyr 
 145                150                155                160
Asn Tyr Ala His Glu Met Thr His Gly Ala Ser Asp Arg Glu Tyr Pro 
                 165                170                175
Arg Leu Gly Gln Met Ile Val Asp Tyr Glu Asn Pro Leu Lys Lys Met 
             180                185                190
Met Glu Glu Phe Val Pro His Ser Lys Ser Leu Ser Asp Ala Leu Ile 
         195                200                205
Ser Leu Gln Met Val Tyr Pro Arg Arg Asn Leu Ser Ala Asp Gln Trp 
     210                215                220
Arg Asn Ala Gln Leu Leu Ser Leu Ile Ser Ala Pro Ser Thr Met Leu 
 225                230                235                240
Asn Pro Ala Gln Ser Asp Thr Met Pro Cys Glu Tyr Leu Ser Leu Asp 
                 245                250                255
Ala Met Glu Lys Trp Ile Ile Phe Gly Phe Ile Leu Cys His Gly Ile 
             260                265                270
Leu Asn Thr Asp Ala Thr Ala Leu Asn Leu Trp Lys Leu Ala Leu Gln 
         275                280                285
Ser Ser Ser Cys Leu Ser Leu Phe Arg Asp Glu Val Phe His Ile His 
     290                295                300
Lys Ala Ala Glu Asp Leu Phe Val Asn Ile Arg Gly Tyr Asn Lys Arg 
 305                310                315                320
Ile Asn Asp Ile Arg Glu Cys Lys Glu Ala Ala Val Ser His Ala Gly 
                 325                330                335
Ser Met His Arg Glu Arg Arg Lys Phe Leu Arg Ser Ala Leu Lys Glu 
             340                345                350
Leu Ala Thr Val Leu Ser Asp Gln Pro Gly Leu Leu Gly Pro Lys Ala 
         355                360                365
Leu Phe Val Phe Met Ala Leu Ser Phe Ala Arg Asp Glu Ile Ile Trp 
     370                375                380
Leu Leu Arg His Ala Asp Asn Met Pro Lys Lys Ser Ala Asp Asp Phe 
 385                390                395                400
Ile Asp Lys His Ile Ala Glu Leu Ile Phe Tyr Met Glu Glu Leu Arg 
                 405                410                415
Ala His Val Arg Lys Tyr Gly Pro Val Met Gln Arg Tyr Tyr Val Gln 
             420                425                430
Tyr Leu Ser Gly Phe Asp Ala Val Val Leu Asn Glu Leu Val Gln Asn 
         435                440                445
Leu Ser Val Cys Pro Glu Asp Glu Ser Ile Ile Met Ser Ser Phe Val 
     450                455                460
Asn Thr Met Thr Ser Leu Ser Val Lys Gln Val Glu Asp Gly Glu Val 
 465                470                475                480
Phe Asp Phe Arg Gly Met Arg Leu Asp Trp Phe Arg Leu Gln Ala Tyr 
                 485                490                495
Thr Ser Val Ser Lys Ala Ser Leu Gly Leu Ala Asp His Arg Glu Leu 
             500                505                510
Gly Lys Met Met Asn Thr Ile Ile Phe His Thr Lys Met Val Asp Ser 
         515                520                525
Leu Val Glu Met Leu Val Glu Thr Ser Asp Leu Ser Ile Phe Cys Phe 
     530                535                540
Tyr Ser Arg Ala Phe Glu Lys Met Phe Gln Gln Cys Leu Glu Leu Pro 
 545                550                555                560
Ser Gln Ser Arg Tyr Ser Ile Ala Phe Pro Leu Leu Cys Thr His Phe 
                 565                570                575
Met Ser Cys Thr His Glu Leu Cys Pro Glu Glu Arg His His Ile Gly 
             580                585                590
Asp Arg Ser Leu Ser Leu Cys Asn Met Phe Leu Asp Glu Met Ala Lys 
         595                600                605
Gln Ala Arg Asn Leu Ile Thr Asp Ile Cys Thr Glu Gln Cys Thr Leu 
     610                615                620
Ser Asp Gln Leu Leu Pro Lys His Cys Ala Lys Thr Ile Ser Gln Ala 
 625                630                635                640
Val Asn Lys Lys Ser Lys Lys Gln Thr Gly Lys Lys Gly Glu Pro Glu 
                 645                650                655
Arg Glu Lys Pro Gly Val Glu Ser Met Arg Lys Asn Arg Leu Val Val 
             660                665                670
Thr Asn Leu Asp Lys Leu His Thr Ala Leu Ser Glu Leu Cys Phe Ser 
         675                680                685
Ile Asn Tyr Val Pro Asn Met Val Val Trp Glu His Thr Phe Thr Pro 
     690                695                700
Arg Glu Tyr Leu Thr Ser His Leu Glu Ile Arg Phe Thr Lys Ser Ile 
 705                710                715                720
Val Gly Met Thr Met Tyr Asn Gln Ala Thr Gln Glu Ile Ala Lys Pro 
                 725                730                735
Ser Glu Leu Leu Thr Ser Val Arg Ala Tyr Met Thr Val Leu Gln Ser 
             740                745                750
Ile Glu Asn Tyr Val Gln Ile Asp Ile Thr Arg Val Phe Asn Asn Val 
         755                760                765
Leu Leu Gln Gln Thr Gln His Leu Asp Ser His Gly Glu Pro Thr Ile 
     770                775                780
Thr Ser Leu Tyr Thr Asn Trp Tyr Leu Glu Thr Leu Leu Arg Gln Val 
 785                790                795                800
Ser Asn Gly His Ile Ala Tyr Phe Pro Ala Met Lys Ala Phe Val Asn 
                 805                810                815
Leu Pro Thr Glu Asn Glu Leu Thr Phe Asn Ala Glu Glu Tyr Ser Asp 
             820                825                830
Ile Ser Glu Met Arg Ser Leu Ser Glu Leu Leu Gly Pro Tyr Gly Met 
         835                840                845
Lys Phe Leu Ser Glu Ser Leu Met Trp His Ile Ser Ser Gln Val Ala 
     850                855                860
Glu Leu Lys Lys Leu Val Val Glu Asn Val Asp Val Leu Thr Gln Met 
 865                870                875                880
Arg Thr Ser Phe Asp Lys Pro Asp Gln Met Ala Ala Leu Phe Lys Arg 
                 885                890                895
Leu Ser Ser Val Asp Ser Val Leu Lys Arg Met Thr Ile Ile Gly Val 
             900                905                910
Ile Leu Ser Phe Arg Ser Leu Ala Gln Glu Ala Leu Arg Asp Val Leu 
         915                920                925
Ser Tyr His Ile Pro Phe Leu Val Ser Ser Ile Glu Asp Phe Lys Asp 
     930                935                940
His Ile Pro Arg Glu Thr Asp Met Lys Val Ala Met Asn Val Tyr Glu 
 945                950                955                960
Leu Ser Ser Ala Ala Gly Leu Pro Cys Glu Ile Asp Pro Ala Leu Val 
                 965                970                975
Val Ala Leu Ser Ser Gln Lys Ser Glu Asn Ile Ser Pro Glu Glu Glu 
             980                985                990
Tyr Lys Ile Ala Cys Leu Leu Met Val Phe Val Ala Val Ser Leu Pro 
         995                1000                1005
Thr Leu Ala Ser Asn Val Met Ser Gln Tyr Ser Pro Ala Ile Glu Gly 
     1010                1015                1020
His Cys Asn Asn Ile His Cys Leu Ala Lys Ala Ile Asn Gln Ile Ala 
 1025                1030                1035                1040
Ala Ala Leu Phe Thr Ile His Lys Gly Ser Ile Glu Asp Arg Leu Lys 
                 1045                1050                1055
Glu Phe Leu Ala Leu Ala Ser Ser Ser Leu Leu Lys Ile Gly Gln Glu 
             1060                1065                1070
Thr Asp Lys Thr Thr Thr Arg Asn Arg Glu Ser Val Tyr Leu Leu Leu 
         1075                1080                1085
Asp Met Ile Val Gln Glu Ser Pro Phe Leu Thr Met Asp Leu Leu Glu 
     1090                1095                1100
Ser Cys Phe Pro Tyr Val Leu Leu Arg Asn Ala Tyr His Ala Val Tyr 
 1105                1110                1115                1120
Lys Gln Ser Val Thr Ser Ser Ala 
                 1125



<210> 2211
<211> 1072
<212> DNA
<213> Rattus norvegicus
<308> D84418
<400> 2211

ggcacgagg  aaggaagtc  ctctgtgga  gtctgaggg  agagctcgc  ccaggtaga  60
gctgcgccg  catcatggg  aagggggac  ccaacaagc  gcggggcaa  atgtcctcg  120
acgccttct  cgtgcagac  tgccgggag  agcacaaga  gaagcatcc  gactcgtcg  180
tcaacttcg  cgagttctc  aagaaatgt  cggagagat  gaagaccat  tctgccaag  240
aaaagtcga  gtttgagga  ttggccaag  gcgacaaag  tcgttatga  agggagatg  300
agaactatg  tcctcccaa  ggtgataag  aaggaaaga  aaaagatcc  aatgctccc  360
agagaccac  gtctgcctt  ttcctgttt  gctctgaac  tcgcccaaa  atcaaaagt  420
aacaccccg  cctgtctat  ggagatact  caaagaaac  gggggagat  tggtctgag  480
aatctgcca  agataaaca  ccgtatgag  agaaagcag  taaactaaa  gagaagtat  540
aaaaggata  tgctgcata  cgtgccaag  gcaaaagtg  agtaggaaa  aagggtcct  600
gtaggccaa  aggctcaaa  aagaagaat  aaccagaag  tgaggaaga  gaggaggag  660
aagaagatg  tgaagatga  gaggaggaa  atgaggatg  agaataagt  tctgtccta  720
agtgtggag  atatgtgct  aggcaatta  tttgctaag  atgtgaaat  caagtgcag  780
tcaacatta  cttcagtat  aaaactgta  agatttttg  atagctgat  agattcttt  840
tagagaaaa  actttttaa  aagggtttg  agctttttc  ggggctaca  cgtacagtt  900
gatttaaag  ttttgatgt  gaatgtttc  aaatattta  tggtttctt  aatttctta  960
gatagcaaa  aaaaaaact  cataggaat  tctattacc  gtaaaagaa  ttttttttt  1020
ggatgttgc  tttttgttt  tttttaaaa  ttgtaataa  ataatgtat  tt  1072



<210> 2212
<211> 209
<212> PRT
<213> Rattus norvegicus
<308> P52925
<400> 2212

Gly Lys Gly Asp Pro Asn Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
  1               5                  10                  15
Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
             20                  25                  30
Ser Ser Val Asn Phe Ala Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
         35                  40                  45
Lys Thr Met Ser Ala Lys Glu Lys Ser Lys Phe Glu Asp Leu Ala Lys 
     50                  55                  60
Ser Asp Lys Ala Arg Tyr Asp Arg Glu Met Lys Asn Tyr Val Pro Pro 
 65                  70                  75                  80
Lys Gly Asp Lys Lys Gly Lys Lys Lys Asp Pro Asn Ala Pro Lys Arg 
                 85                  90                  95
Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu His Arg Pro Lys Ile 
             100                105                110
Lys Ser Glu His Pro Gly Leu Ser Ile Gly Asp Thr Ala Lys Lys Leu 
         115                120                125
Gly Glu Met Trp Ser Glu Gln Ser Ala Lys Asp Lys Gln Pro Tyr Glu 
     130                135                140
Gln Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
 145                150                155                160
Tyr Arg Ala Lys Gly Lys Ser Glu Val Gly Lys Lys Gly Pro Gly Arg 
                 165                170                175
Pro Thr Gly Ser Lys Lys Lys Asn Glu Pro Glu Asp Glu Glu Glu Glu 
             180                185                190
Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Glu Asp Glu Asp Glu 
         195                200                205
Glu 
     210



<210> 2213
<211> 1066
<212> DNA
<213> Homo sapiens
<308> Z17240
<400> 2213

cgggaagag  acaagaaga  acacccgga  tcttccgtc  atttcgcgg  attctccaa  60
aagtgttcg  agagatgga  gaccatgtc  gcaaaggag  agtcgaagt  tgaagatat  120
gcaaaaagt  acaaagctc  ctatgacag  gagatgaaa  attacgttc  tcccaaagg  180
gataagaag  ggaagaaaa  ggaccccaa  gctcctaaa  ggccaccat  tgccttctt  240
ctgttttgc  ctgaacatc  cccaaagat  aaaagtgaa  accctggcc  atccattgg  300
gatactgca  agaaattgg  tgaaatgtg  tctgagcag  cagccaaag  taaacaacc  360
tatgaacag  aagcagcta  gctaaagga  aaatatgaa  aggatattg  tgcatatgg  420
gccaagggc  aaagtgaag  aggaaagaa  ggccctggc  ggccaacag  ctcaaagaa  480
aagaacgaa  cagaagatg  ggaggagga  gaggaagaa  aagatgaag  tgaggagga  540
gaggatgaa  atgaagaat  aatggctat  ctttaatga  gcgtgtgga  tgtgtgtgt  600
tgctcaggc  attattttg  taagaatgt  aattcaagt  cagctcaat  ctagcttca  660
tataaaaac  gtacagatt  ttgtatagc  gataagatt  tctgtagag  aaatacttt  720
aaaaaatgc  ggttgtagc  ttttgatgg  ctactcata  agttagatt  tacagcttc  780
gatgttgaa  gttcctaaa  atttaatgg  ttttttaat  tcttgtgta  ggtagcaca  840
caaacttgt  ggatttagt  tcaatagta  attttgggt  ttttaggat  ttgcatttc  900
tttttttaa  aaaaatttt  taataaaat  atgtatatt  aaagcaggg  gcagaatgt  960
aaagaagct  ctatttgac  ccttgtatt  tcctagtga  agcggaggt  tttactggt  1020
aaaaatata  ggaatgggc  gggagcagt  gctcacacc  gaattc  1066



<210> 2214
<211> 208
<212> PRT
<213> Homo sapiens
<308> P26583
<400> 2214

Gly Lys Gly Asp Pro Asn Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
  1               5                  10                  15
Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
             20                  25                  30
Ser Ser Val Asn Phe Ala Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
         35                  40                  45
Lys Thr Met Ser Ala Lys Glu Lys Ser Lys Phe Glu Asp Met Ala Lys 
     50                  55                  60
Ser Asp Lys Ala Arg Tyr Asp Arg Glu Met Lys Asn Tyr Val Pro Pro 
 65                  70                  75                  80
Lys Gly Asp Lys Lys Gly Lys Lys Lys Asp Pro Asn Ala Pro Lys Arg 
                 85                  90                  95
Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu His Arg Pro Lys Ile 
             100                105                110
Lys Ser Glu His Pro Gly Leu Ser Ile Gly Asp Thr Ala Lys Lys Leu 
         115                120                125
Gly Glu Met Trp Ser Glu Gln Ser Ala Lys Asp Lys Gln Pro Tyr Glu 
     130                135                140
Gln Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
 145                150                155                160
Tyr Arg Ala Lys Gly Lys Ser Glu Ala Gly Lys Lys Gly Pro Gly Arg 
                 165                170                175
Pro Thr Gly Ser Lys Lys Lys Asn Glu Pro Glu Asp Glu Glu Glu Glu 
             180                185                190
Glu Glu Glu Glu Asp Glu Asp Glu Glu Glu Glu Asp Glu Asp Glu Glu 
         195                200                205



<210> 2215
<211> 3205
<212> DNA
<213> Rattus norvegicus
<308> D84667
<400> 2215

ttactatgg  atcggtagt  tcctgacag  tcggaaagc  ggaaagcaa  cgccgagaa  60
aaaggctcg  gcccagcgg  ctcttacat  gcaacccat  aaggaattg  tattttggg  120
cctgcaagt  gggtccggt  caacttgag  tagcgtgaa  gccccttca  gcggcgccg  180
gggcagccc  gcagccggg  cctggtgca  ccgccgcgg  cgctgtcag  gaagcgcag  240
cggccaatg  aacccggga  cggccgctg  tgctgaggc  gcggtgtcg  cagtccgac  300
ccgaccgcc  gcaccccct  cgcgagggt  ccccggagc  tggaagctc  aagtctggc  360
gtagccatg  gagacatgg  agtggagcc  gccaccctg  agccaactt  tgagcctac  420
cctagccca  cagggaata  cgggggctc  ctactaagc  tcatcacgg  gggggtcgg  480
gaactgtca  tgattgacc  tgaggtggc  cagaaggcc  gccaggagg  actggagaa  540
gtcaagctt  tgcatggag  tgtagccat  tctagcaaa  gcagcccac  ggagttggt  600
aatggggat  gtgtggaca  tgagatccg  tgcctagat  atccaccta  cgagatcag  660
gaggaagaa  atgagatgg  gcctggtgt  gtctctggc  cagccaaag  aacaagaag  720
agacgacag  acaactcag  caaacagtc  tggctcctg  ggctgtttg  atcaaaact  780
tttgacatc  ctatggcca  ttcatactt  tataactcc  aggagccgg  agtgcaagc  840
tacattggc  accggctct  ctgctttcg  aatgaggat  tggacttct  tttgcccca  900
ttgcttaac  tgtatatcc  tatggatga  gatgtgggt  atgccatta  accctacat  960
gtccaccgt  gtcgccaga  catcaactt  tccctccag  gtgccctgt  gcttggggc  1020
tactcttca  acatgcaca  ttccactca  cgacactcc  gagggacca  gttacggaa  1080
ctaatcctc  cagatgagc  gaagccagc  caccgaaag  gggagctgc  aactttaag  1140
ccagcccct  acacaggac  gtctccctc  aaaaggact  accagcgct  taagtcaga  1200
gccacggcc  gcataagtc  cagcagcaa  ctgaaacga  cagccagca  ccctaaagt  1260
gagaatgag  atgaggagc  ctcctccag  accgagagt  ttgataatt  attcagttc  1320
cctgtccgg  tggcccctg  gcgagaatt  atcaagtcc  tgatggcaa  cggcaaacg  1380
ctggccacg  tccccacta  agagcaaaa  acacaaagg  tgatctcag  actttccct  1440
ctcaaccat  agctccctg  ccgagtctg  ctgcccaca  ctggctttg  ccaccacgt  1500
gtccgtgtg  cccacacac  agctgttgt  ctcaattcc  aggataagg  tccctacct  1560
atctatgtg  aagttcttg  atgtgaaaa  ttcgacaca  ctaatgttc  tgcccggat  1620
cctgaaaac  gaattcgga  tacgaggtc  gtggagaac  tgccggaat  tggtatcac  1680
cacgagcag  gggctggca  cttcagcac  gtgcccaat  atgacaatg  cgatgaagc  1740
tggtcggtg  atgacatag  cgagctgca  gtggagctc  cagaagtgc  caccaacag  1800
tgtgacaac  tctctcagt  ctcggtgga  agcatcacc  gccaggaga  caaggagcc  1860
gtgttcatt  cggcagggg  catcagacg  cgcctttca  aacagctgg  tcacactcc  1920
acagccttc  aacgagacc  tgaagaccc  tctgcagtc  ccctcaaag  gccctggca  1980
gagaaagtg  ggaggatca  agaaggttc  ccgtatggc  atcttccca  ttggcgact  2040
ctttcagtc  ttgtcaagt  tggagatga  cttcgccag  agctgctgg  tttccaggt  2100
ttgaaacaa  tgcagtcca  ttgggaaca  gagcgagtg  ctctttgga  caagccata  2160
aagattctt  tgatttcag  tgacagtgg  atgattgaa  cagtagtca  cgctgtgtc  2220
atccaccag  tgaagaaac  gtcacagct  tccttgctc  attacttcc  gcaggagca  2280
ggcagttac  ccactgagg  attcctcag  gcccagcgc  attttgtgc  aagttgtgc  2340
ggctactgc  tggtctgct  cctattaca  gtcaaggac  ggcacaatg  gaacatcct  2400
ctggacgca  aaggtcaca  catccacat  gactttggc  tcatccttt  cagctcacc  2460
cgaaacctg  gcttcgaga  gtcagcctt  aagctgacc  cagaatttg  ggatgtaat  2520
ggcggcctg  acggtgata  gttcaacta  tataagatg  tcatgctgc  agggctgat  2580
gctgctcgc  aacacatgg  caaggtggt  cagattgtg  agatcatgc  gcaaggttc  2640
cagcttcct  gcttccatg  ctccagcac  attcgcaac  tcaaagaga  gttccacat  2700
agcatgact  aggagcagc  gcagctgct  gtggagcag  tggtggacg  cagcatgag  2760
tccatcacc  ccaaactct  cgatggctt  cagtacctc  ccaatggca  catgtgaca  2820
cactttcag  cccagaagt  gtgggattg  aggcaccct  cttaggagg  cccttgcct  2880
agaaaacct  aatcacaaa  tcccaccta  ctaaccacc  acccaaggg  aatggaagg  2940
aaaaaacac  aaggatcat  tggtaacca  gagagctgg  caaagggta  gagagccaa  3000
catggggtc  agacttgct  gggcttccc  acctcttgc  gtgtcagta  tgccacctg  3060
cagatccca  gactcactg  cctccagag  acagagatg  tgaacatga  gaggactgg  3120
accttcttc  cctcgggga  ctcatcttt  actatccct  ggtcccagc  agatgggag  3180
agtgggttc  tggtactta  gactt  3205



<210> 2216
<211> 816
<212> PRT
<213> Rattus norvegicus
<308> BAA18969
<400> 2216

Met Gly Asp Met Val Val Glu Pro Ala Thr Leu Lys Pro Thr Ser Glu 
  1               5                  10                  15
Pro Thr Pro Ser Pro Ser Gly Asn Asn Gly Gly Ser Leu Leu Ser Val 
             20                  25                  30
Ile Thr Glu Gly Val Gly Glu Leu Ser Val Ile Asp Pro Glu Val Ala 
         35                  40                  45
Gln Lys Ala Cys Gln Glu Val Leu Glu Lys Val Lys Leu Leu His Gly 
     50                  55                  60
Gly Val Ala Ile Ser Ser Lys Gly Ser Pro Leu Glu Leu Val Asn Gly 
 65                  70                  75                  80
Asp Gly Val Asp Asn Glu Ile Arg Cys Leu Asp Asp Pro Pro Thr Glu 
                 85                  90                  95
Ile Arg Glu Glu Glu Asp Glu Met Glu Pro Gly Val Val Ser Gly Thr 
             100                105                110
Ala Lys Gly Thr Arg Arg Arg Arg Gln Asn Asn Ser Ala Lys Gln Ser 
         115                120                125
Trp Leu Leu Arg Leu Phe Glu Ser Lys Leu Phe Asp Ile Ser Met Ala 
     130                135                140
Ile Ser Tyr Leu Tyr Asn Ser Lys Glu Pro Gly Val Gln Ala Tyr Ile 
 145                150                155                160
Gly Asn Arg Leu Phe Cys Phe Arg Asn Glu Asp Val Asp Phe Tyr Leu 
                 165                170                175
Pro Gln Leu Leu Asn Met Tyr Ile His Met Asp Glu Asp Val Gly Asp 
             180                185                190
Ala Ile Lys Pro Tyr Ile Val His Arg Cys Arg Gln Ser Ile Asn Phe 
         195                200                205
Ser Leu Gln Cys Ala Leu Leu Leu Gly Ala Tyr Ser Ser Asp Met His 
     210                215                220
Ile Ser Thr Gln Arg His Ser Arg Gly Thr Lys Leu Arg Lys Leu Ile 
 225                230                235                240
Leu Ser Asp Glu Leu Lys Pro Ala His Arg Lys Arg Glu Leu Pro Thr 
                 245                250                255
Leu Ser Pro Ala Pro Asp Thr Gly Leu Ser Pro Ser Lys Arg Thr His 
             260                265                270
Gln Arg Ser Lys Ser Asp Ala Thr Ala Ser Ile Ser Leu Ser Ser Asn 
         275                280                285
Leu Lys Arg Thr Ala Ser Asn Pro Lys Val Glu Asn Glu Asp Glu Glu 
     290                295                300
Leu Ser Ser Ser Thr Glu Ser Ile Asp Asn Ser Phe Ser Ser Pro Val 
 305                310                315                320
Arg Leu Ala Pro Glu Arg Glu Phe Ile Lys Ser Leu Met Ala Ile Gly 
                 325                330                335
Lys Arg Leu Ala Thr Leu Pro Thr Lys Glu Gln Lys Thr Gln Arg Leu 
             340                345                350
Ile Ser Glu Leu Ser Leu Leu Asn His Lys Leu Pro Ala Arg Val Trp 
         355                360                365
Leu Pro Thr Ala Gly Phe Asp His His Val Val Arg Val Pro His Thr 
     370                375                380
Gln Ala Val Val Leu Asn Ser Lys Asp Lys Ala Pro Tyr Leu Ile Tyr 
 385                390                395                400
Val Glu Val Leu Glu Cys Glu Asn Phe Asp Thr Thr Asn Val Pro Ala 
                 405                410                415
Arg Ile Pro Glu Asn Arg Ile Arg Ser Thr Arg Ser Val Glu Asn Leu 
             420                425                430
Pro Glu Cys Gly Ile Thr His Glu Gln Arg Ala Gly Ser Phe Ser Thr 
         435                440                445
Val Pro Asn Tyr Asp Asn Asp Asp Glu Ala Trp Ser Val Asp Asp Ile 
     450                455                460
Gly Glu Leu Gln Val Glu Leu Pro Glu Val His Thr Asn Ser Cys Asp 
 465                470                475                480
Asn Ile Ser Gln Phe Ser Val Asp Ser Ile Thr Ser Gln Glu Ser Lys 
                 485                490                495
Glu Pro Val Phe Ile Ala Ala Gly Asp Ile Arg Arg Arg Leu Ser Glu 
             500                505                510
Gln Leu Ala His Thr Pro Thr Ala Phe Lys Arg Asp Pro Glu Asp Pro 
         515                520                525
Ser Ala Val Ala Leu Lys Glu Pro Trp Gln Glu Lys Val Arg Arg Ile 
     530                535                540
Arg Glu Gly Ser Pro Tyr Gly His Leu Pro Asn Trp Arg Leu Leu Ser 
 545                550                555                560
Val Ile Val Lys Cys Gly Asp Asp Leu Arg Gln Glu Leu Leu Ala Phe 
                 565                570                575
Gln Val Leu Lys Gln Leu Gln Ser Ile Trp Glu Gln Glu Arg Val Pro 
             580                585                590
Leu Trp Ile Lys Pro Tyr Lys Ile Leu Val Ile Ser Ala Asp Ser Gly 
         595                600                605
Met Ile Glu Pro Val Val Asn Ala Val Ser Ile His Gln Val Lys Lys 
     610                615                620
Gln Ser Gln Leu Ser Leu Leu Asp Tyr Phe Leu Gln Glu His Gly Ser 
 625                630                635                640
Tyr Thr Thr Glu Ala Phe Leu Ser Ala Gln Arg Asn Phe Val Gln Ser 
                 645                650                655
Cys Ala Gly Tyr Cys Leu Val Cys Tyr Leu Leu Gln Val Lys Asp Arg 
             660                665                670
His Asn Gly Asn Ile Leu Leu Asp Ala Glu Gly His Ile Ile His Ile 
         675                680                685
Asp Phe Gly Phe Ile Leu Ser Ser Ser Pro Arg Asn Leu Gly Phe Glu 
     690                695                700
Thr Ser Ala Phe Lys Leu Thr Thr Glu Phe Val Asp Val Met Gly Gly 
 705                710                715                720
Leu Asn Gly Asp Met Phe Asn Tyr Tyr Lys Met Leu Met Leu Gln Gly 
                 725                730                735
Leu Ile Ala Ala Arg Lys His Met Asp Lys Val Val Gln Ile Val Glu 
             740                745                750
Ile Met Gln Gln Gly Ser Gln Leu Pro Cys Phe His Gly Ser Ser Thr 
         755                760                765
Ile Arg Asn Leu Lys Glu Arg Phe His Met Ser Met Thr Glu Glu Gln 
     770                775                780
Leu Gln Leu Leu Val Glu Gln Met Val Asp Gly Ser Met Arg Ser Ile 
 785                790                795                800
Thr Thr Lys Leu Tyr Asp Gly Phe Gln Tyr Leu Thr Asn Gly Ile Met 
                 805                810                815



<210> 2217
<211> 334
<212> DNA
<213> Homo sapiens
<308> AI205643
<400> 2217

ttctcagga  tcctttatt  ttgtagtaa  aataatact  acaaacagt  ggggaacta  60
ggagaaaac  agaccatta  aactgttgt  gtcgaatct  cattcaggc  tctcttttt  120
tgtgacttg  acaatgtgg  gttgaagcg  gtgagagaa  atggaagga  aagttaatg  180
tctggcggc  acggtggac  atgtagggc  taatggcat  acccacgtc  tcatccatg  240
ggatgtaca  gttaagcaa  tggggcaga  agaagtcca  gtcctcgtt  cgaaagcag  300
agagccggt  gccaatggt  gcttgtact  cagc  334



<210> 2218
<211> 801
<212> PRT
<213> Homo sapiens
<308> AAC51156
<400> 2218

Met Gly Asp Thr Val Val Glu Pro Ala Pro Leu Lys Pro Thr Ser Glu 
  1               5                  10                  15
Pro Thr Ser Gly Pro Pro Gly Asn Asn Gly Gly Ser Leu Leu Ser Val 
             20                  25                  30
Ile Thr Glu Gly Val Gly Glu Leu Ser Val Ile Asp Pro Glu Val Ala 
         35                  40                  45
Gln Lys Ala Cys Gln Glu Val Leu Glu Lys Val Lys Leu Leu His Gly 
     50                  55                  60
Gly Val Ala Val Ser Ser Arg Gly Thr Pro Leu Glu Leu Val Asn Gly 
 65                  70                  75                  80
Asp Gly Val Asp Ser Glu Ile Arg Cys Leu Asp Asp Pro Pro Ala Gln 
                 85                  90                  95
Ile Arg Glu Glu Glu Asp Glu Met Gly Ala Ala Val Ala Ser Gly Thr 
             100                105                110
Ala Lys Gly Ala Arg Arg Arg Arg Gln Asn Asn Ser Ala Lys Gln Ser 
         115                120                125
Trp Leu Leu Arg Leu Phe Glu Ser Lys Leu Phe Asp Ile Ser Met Ala 
     130                135                140
Ile Ser Tyr Leu Tyr Asn Ser Lys Glu Pro Gly Val Gln Ala Tyr Ile 
 145                150                155                160
Gly Asn Arg Leu Phe Cys Phe Arg Asn Glu Asp Val Asp Phe Tyr Leu 
                 165                170                175
Pro Gln Leu Leu Asn Met Tyr Ile His Met Asp Glu Asp Val Gly Asp 
             180                185                190
Ala Ile Lys Pro Tyr Ile Val His Arg Cys Arg Gln Ser Ile Asn Phe 
         195                200                205
Ser Leu Gln Cys Ala Leu Leu Val Gly Ala Tyr Ser Ser Asp Met His 
     210                215                220
Ile Ser Thr Gln Arg His Ser Arg Gly Thr Lys Leu Arg Lys Leu Ile 
 225                230                235                240
Leu Ser Asp Glu Leu Lys Pro Ala His Arg Lys Arg Glu Leu Pro Ser 
                 245                250                255
Leu Ser Pro Ala Pro Asp Thr Gly Leu Ser Pro Ser Lys Arg Thr His 
             260                265                270
Gln Arg Ser Lys Ser Asp Ala Thr Ala Ser Ile Ser Leu Ser Ser Asn 
         275                280                285
Leu Lys Arg Thr Ala Ser Asn Pro Lys Val Glu Asn Glu Asp Glu Pro 
     290                295                300
Val Arg Leu Ala Pro Glu Arg Glu Phe Ile Lys Ser Leu Met Ala Ile 
 305                310                315                320
Gly Lys Arg Val Val Thr Leu Pro Thr Lys Glu Gln Lys Thr Gln Arg 
                 325                330                335
Leu Ile Ser Glu Leu Ser Leu Leu Asn His Lys Leu Pro Ala Arg Val 
             340                345                350
Trp Leu Ser Thr Ala Gly Phe Asp His His Val Val Arg Val Pro His 
         355                360                365
Thr Gln Ala Val Val Leu Asn Ser Lys Asp Lys Ala Pro Tyr Leu Ile 
     370                375                380
Tyr Val Glu Val Leu Glu Cys Glu Asn Phe Asp Thr Thr Ser Val Pro 
 385                390                395                400
Ala Arg Ile Pro Glu Asn Arg Ile Arg Ser Thr Arg Ser Val Glu Asn 
                 405                410                415
Leu Pro Glu Cys Gly Ile Thr His Glu Gln Arg Ala Gly Ser Phe Ser 
             420                425                430
Thr Val Pro Asn Tyr Asp Asn Asp Asp Glu Ala Trp Ser Val Asp Asp 
         435                440                445
Ile Gly Glu Leu Gln Val Glu Leu Pro Glu Val His Thr Asn Ser Cys 
     450                455                460
Asp Asn Ile Ser Gln Phe Ser Val Asp Ser Ile Thr Ser Gln Glu Ser 
 465                470                475                480
Lys Glu Pro Val Phe Ile Ala Ala Gly Asp Ile Arg Arg Arg Leu Ser 
                 485                490                495
Glu Gln Leu Ala His Thr Pro Thr Ala Phe Lys Arg Asp Pro Glu Asp 
             500                505                510
Pro Ser Ala Val Ala Leu Lys Glu Pro Trp Gln Glu Lys Val Arg Arg 
         515                520                525
Ile Arg Glu Gly Ser Pro Tyr Gly His Leu Pro Asn Trp Arg Leu Leu 
     530                535                540
Ser Val Ile Val Lys Cys Gly Asp Asp Leu Arg Gln Glu Leu Leu Ala 
 545                550                555                560
Phe Gln Val Leu Lys Gln Leu Gln Ser Ile Trp Glu Gln Glu Arg Val 
                 565                570                575
Pro Leu Trp Ile Lys Pro Tyr Lys Ile Leu Val Ile Ser Ala Asp Ser 
             580                585                590
Gly Met Ile Glu Pro Val Val Asn Ala Val Ser Ile His Gln Val Lys 
         595                600                605
Lys Gln Ser Gln Leu Ser Leu Leu Asp Tyr Phe Leu Gln Glu His Gly 
     610                615                620
Ser Tyr Thr Thr Glu Ala Phe Leu Ser Ala Gln Arg Asn Phe Val Gln 
 625                630                635                640
Ser Cys Ala Gly Tyr Cys Leu Val Cys Tyr Leu Leu Gln Val Lys Asp 
                 645                650                655
Arg His Asn Gly Asn Ile Leu Leu Asp Ala Glu Gly His Ile Ile His 
             660                665                670
Ile Asp Phe Gly Phe Ile Leu Ser Ser Ser Pro Arg Asn Leu Gly Phe 
         675                680                685
Glu Thr Ser Ala Phe Lys Leu Thr Thr Glu Phe Val Asp Val Met Gly 
     690                695                700
Gly Leu Asp Gly Asp Met Phe Asn Tyr Tyr Lys Met Leu Met Leu Gln 
 705                710                715                720
Gly Leu Ile Ala Ala Arg Lys His Met Asp Lys Val Val Gln Ile Val 
                 725                730                735
Glu Ile Met Gln Gln Gly Ser Gln Leu Pro Cys Phe His Gly Ser Ser 
             740                745                750
Thr Ile Arg Asn Leu Lys Glu Arg Phe His Met Ser Met Thr Glu Glu 
         755                760                765
Gln Leu Gln Leu Leu Val Glu Gln Met Val Asp Gly Ser Met Arg Ser 
     770                775                780
Ile Thr Thr Lys Leu Tyr Asp Gly Phe Gln Tyr Leu Thr Asn Gly Ile 
 785                790                795                800
Met 
                 805



<210> 2219
<211> 3709
<212> DNA
<213> Rattus norvegicus
<308> D85183
<400> 2219

cgcgctcac  gccgatctc  catccttgc  ctgcagccg  ggcccatgg  gcccgccgg  60
ccggcccct  gccgcctag  gccgctgct  ttctgcctg  tgctctccg  gtcctgttt  120
tgtgcagga  ccagcggga  agaactgaa  gtgactcag  ctgacaaat  agtgtctgt  180
gctgctgga  attcggcca  tctgaactg  actgtgtcc  ccctgacgc  tgtgggacc  240
attaagtgg  tcaaaggag  agggcaaaa  cggagcccg  tctacagtt  cataggagg  300
gaacacttt  ctcgaatta  aaatgtttc  gatgctact  agagaaaca  tatggactt  360
agcatctgt  tcagtaatg  cacccctga  gatgctggc  cctactact  tgtgaagtt  420
cagaaagga  tagtagagc  tgacacaga  attaaatct  gagggggaa  aacgctcta  480
gtactcgcc  aaccttctt  accggaagt  tcgggccca  actccaggg  ctctcctgg  540
cagacagtg  acttcacct  caagtctta  ggcttctct  cccggaata  caccctgaa  600
tggctcaaa  atgggaaag  actctccca  ttggagacc  ccatctcca  taaaagcaa  660
gtctcctac  acatctcca  cacagtcag  gtgaaacta  gccccgagg  cattcattc  720
cgggtcatc  gcgaggtag  ccacgtcac  ttggaagga  gcccgctta  tgggaccgc  780
aacttttct  acatcatcc  agtttcacc  accttgaag  tcacccaac  gcccctgac  840
cccgcgagc  aggtgaacc  cacctgcca  gtgcagaag  tctacccca  ggctctcca  900
ctgaactgg  tggagaatg  aaacttatc  cggacggac  agcccgagc  tttcacaga  960
aacagggat  ggacctata  ttacacaag  ctgttcctg  tgaactcat  tgctcacag  1020
gaggatgtg  tattcacgt  ccaggtgga  catgacagt  agccagcga  caccgaaaa  1080
cataccgtg  gggcatttg  ccactcgag  agtggaggc  gcatggaaa  catccctga  1140
aataatgct  actacaact  gaacgtctt  atcggtgtg  gtgtggcgt  tgctttgct  1200
gtagtcctg  tgatggctg  cctctacct  ctccgaatc  aacagaaga  agccaaggg  1260
tcaacttct  ccacacggt  gcacgagcc  gagaagaat  ccagggaaa  aacccagat  1320
caggacaca  atgacatca  cgacatcac  tacgcagac  tgaatctgc  caaagagaa  1380
aagcccgcc  cccgggtcc  cgagcccaa  aaccacaca  aatatgcaa  cattgagac  1440
ggcaaactg  ctaggccag  ggataccct  acctatgct  acctggaca  ggtccacct  1500
aaccgggca  agccaaccc  caagcctga  ccatccttc  cagagtatg  cagtgtcca  1560
gtccagagg  agtgaatgg  gctgtggtt  gctctaggc  ccatcccca  aagttttct  1620
gtcctacat  gagtggcca  gatgaggac  accagccag  cagccctgt  tccagaagg  1680
caggtggca  aggtcctag  accaggggt  agggtggct  ctgtcttcc  tccgtggct  1740
tccaacacc  cttggacac  catgtcccc  tcttctgga  ctgggtgtt  cagaaccag  1800
gggggaact  gagaaagct  cctagaatc  aagaagcgt  gtgcctcag  ccatcacac  1860
gggtctgga  cctggtctt  gcaaccccc  ggttgcttc  ttgatgctc  agcgcctgg  1920
cttctgtgt  gagaagagt  caccatctc  atccaactt  agcttcggg  ccagactcc  1980
tttagatca  accgcccca  gtgtggaag  actacacca  gagtcaaca  gttttcaca  2040
gtgtgaaga  ctacaccag  agtcaacaa  tttacgcca  cagtgctag  ctccccacc  2100
cccaggctg  cgagccctg  ggagaagga  ccctcttcc  cctagacca  cagagactc  2160
ctgggcatg  tcagtgtgg  cccaccctt  cagtcccag  tcgcttcct  cagctagca  2220
taactcaac  gcattgctc  gtggacgcc  gtaaattat  gagaaatgt  aactgtgca  2280
tcttgaagc  aaggtgtta  aaaatttga  ttgtgctgt  tagttgttg  tgggtttct  2340
ttcttttct  ttttttctt  ctttttctt  cttcttttt  tcttttccc  cttaaaaca  2400
cagcagcag  atcttggct  tttgtcatg  gttgaatgg  tgggtcttg  gaagtctga  2460
gtctaacag  ttattgtcc  ggaaggatt  tcttatagc  gaaacagat  ttttttcca  2520
ttcccagca  cctgaggac  aagaaggat  cctctgttg  cattttcag  actcagcgt  2580
actgggatg  gccaggctc  gtccccaca  ctggccctt  gcctccatg  ctactgtgg  2640
aagtgcagc  ttgtctaat  cagtgctga  gttggccat  cctcattga  gagagaagg  2700
cagtgacaa  ctcacaagc  ctgcagagg  atacggaga  aagggacgc  cggccagca  2760
ccggtattc  agcgctctg  ggtaatcag  gcaaggagt  tgttattac  atcagacct  2820
agcaggatc  tactggaac  gaacctgat  atacctgtg  caacacagc  gtcagccag  2880
gcaaaccac  ccactgtcc  agagtctgg  cagaggctc  gacccccac  cttcaaact  2940
gatgtcggg  cctggctgg  cccaatggc  agcagatgt  gcaacccta  ctatctggt  3000
ttaacatgc  gctcagtaa  ttgaggcgc  aatgtcccc  catgccggg  gattcctgg  3060
tccggctct  caagtaaga  gctgattca  cctgcctgt  tctgtaggt  tgacaggga  3120
gtcaggaaa  cagccagga  tcatctcta  agggctggt  acctgatac  tcccataaa  3180
gcatccagg  gttagctga  ccaatagtc  gagttgacc  cactggcct  gcaaaccgt  3240
acttgtctt  ggcccagcc  tggtcttgg  ctgtcttct  attccaaag  gttggtagg  3300
aaagatcca  cctcttccc  tctgccaag  gacatcacg  gtgtacaca  acacatgcg  3360
gcgcgcgca  acacacaca  acacacaca  acacacaca  acacacaca  acgggtgta  3420
aggtgagtt  aaaggatgt  ctcgctgac  tcctaattt  gtcttaagt  tttttggag  3480
gagaaagga  agaggcagg  aagatacgt  gctctagct  tagtcaggc  gcctggggg  3540
atccccaag  ctatgtatg  aaccctggt  cgaaagcgc  ctgtgagga  tgggatttc  3600
gttttatct  tagaccaga  gagaaggag  aaggcccca  tttgtacat  gttgcaact  3660
aaaattttt  gcttgcaaa  tatttttgt  ataaagatt  ctgggtaac  3709



<210> 2220
<211> 509
<212> PRT
<213> Rattus norvegicus
<308> BAA12734
<400> 2220

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Phe 
  1               5                  10                  15
Cys Leu Leu Leu Ser Ala Ser Cys Phe Cys Ala Gly Ala Ser Gly Lys 
             20                  25                  30
Glu Leu Lys Val Thr Gln Ala Asp Lys Ser Val Ser Val Ala Ala Gly 
         35                  40                  45
Asp Ser Ala Thr Leu Asn Cys Thr Val Ser Ser Leu Thr Pro Val Gly 
     50                  55                  60
Pro Ile Lys Trp Phe Lys Gly Glu Gly Gln Asn Arg Ser Pro Ile Tyr 
 65                  70                  75                  80
Ser Phe Ile Gly Gly Glu His Phe Pro Arg Ile Thr Asn Val Ser Asp 
                 85                  90                  95
Ala Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Cys Ile Ser Asn Val 
             100                105                110
Thr Pro Glu Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Gln Lys Gly 
         115                120                125
Ile Val Glu Pro Asp Thr Glu Ile Lys Ser Gly Gly Gly Thr Thr Leu 
     130                135                140
Tyr Val Leu Ala Lys Pro Ser Ser Pro Glu Val Ser Gly Pro Asp Ser 
 145                150                155                160
Arg Gly Ser Pro Gly Gln Thr Val Asn Phe Thr Cys Lys Ser Tyr Gly 
                 165                170                175
Phe Ser Pro Arg Asn Ile Thr Leu Lys Trp Leu Lys Asp Gly Lys Glu 
             180                185                190
Leu Ser His Leu Glu Thr Thr Ile Ser Ser Lys Ser Asn Val Ser Tyr 
         195                200                205
Asn Ile Ser Ser Thr Val Ser Val Lys Leu Ser Pro Glu Asp Ile His 
     210                215                220
Ser Arg Val Ile Cys Glu Val Ala His Val Thr Leu Glu Gly Arg Pro 
 225                230                235                240
Leu Asn Gly Thr Ala Asn Phe Ser Asn Ile Ile Arg Val Ser Pro Thr 
                 245                250                255
Leu Lys Ile Thr Gln Gln Pro Leu Thr Pro Ala Ser Gln Val Asn Leu 
             260                265                270
Thr Cys Gln Val Gln Lys Phe Tyr Pro Lys Ala Leu Gln Leu Asn Trp 
         275                280                285
Leu Glu Asn Gly Asn Leu Ser Arg Thr Asp Lys Pro Glu His Phe Thr 
     290                295                300
Asp Asn Arg Asp Gly Thr Tyr Asn Tyr Thr Ser Leu Phe Leu Val Asn 
 305                310                315                320
Ser Ser Ala His Arg Glu Asp Val Val Phe Thr Cys Gln Val Glu His 
                 325                330                335
Asp Ser Gln Pro Ala Ile Thr Glu Asn His Thr Val Arg Ala Phe Ala 
             340                345                350
His Ser Ser Ser Gly Gly Ser Met Glu Thr Ile Pro Asp Asn Asn Ala 
         355                360                365
Tyr Tyr Asn Trp Asn Val Phe Ile Gly Val Gly Val Ala Cys Ala Leu 
     370                375                380
Leu Val Val Leu Leu Met Ala Ala Leu Tyr Leu Leu Arg Ile Lys Gln 
 385                390                395                400
Lys Lys Ala Lys Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu 
                 405                410                415
Lys Asn Ala Arg Glu Ile Thr Gln Ile Gln Asp Thr Asn Asp Ile Asn 
             420                425                430
Asp Ile Thr Tyr Ala Asp Leu Asn Leu Pro Lys Glu Lys Lys Pro Ala 
         435                440                445
Pro Arg Val Pro Glu Pro Asn Asn His Thr Glu Tyr Ala Ser Ile Glu 
     450                455                460
Thr Gly Lys Leu Pro Arg Pro Glu Asp Thr Leu Thr Tyr Ala Asp Leu 
 465                470                475                480
Asp Met Val His Leu Asn Arg Ala Gln Pro Thr Pro Lys Pro Glu Pro 
                 485                490                495
Ser Phe Ser Glu Tyr Ala Ser Val Gln Val Gln Arg Lys 
             500                505



<210> 2221
<211> 503
<212> PRT
<213> Homo sapiens
<308> NP_004639
<400> 2221

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
  1               5                  10                  15
Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
             20                  25                  30
Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala Ala Gly 
         35                  40                  45
Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro Val Gly 
     50                  55                  60
Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu Ile Tyr 
 65                  70                  75                  80
Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Ser 
                 85                  90                  95
Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr 
             100                105                110
Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
         115                120                125
Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 
     130                135                140
Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr 
 145                150                155                160
Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 
                 165                170                175
Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 
             180                185                190
Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile 
         195                200                205
His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln 
     210                215                220
Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg 
 225                230                235                240
Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu 
                 245                250                255
Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys 
             260                265                270
Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu 
         275                280                285
Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn 
     290                295                300
Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser 
 305                310                315                320
Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly 
                 325                330                335
Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His Pro 
             340                345                350
Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn Glu 
         355                360                365
Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val Ala 
     370                375                380
Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys Ala 
 385                390                395                400
Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn Ala 
                 405                410                415
Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu Asn 
             420                425                430
Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn Asn 
         435                440                445
His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser Glu 
     450                455                460
Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg Thr 
 465                470                475                480
Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr Ala 
                 485                490                495
Ser Val Gln Val Pro Arg Lys 
             500



<210> 2222
<211> 4862
<212> DNA
<213> Rattus norvegicus
<308> D85189
<400> 2222

gccgaggct  gcccctcct  gcaaggctg  tccagagct  gcgggcacg  gagctcctc  60
ccgggagct  ccttccccg  aaggccggg  cccagtggc  gactcgtgg  gagcgaggc  120
gcaccttcg  tcccaggag  ttgacctgt  cttaaaagt  aaagaagaa  tctaagaaa  180
acgctatgg  aaagagaat  aaagctaag  ccacttcag  caaacccgg  agtccatat  240
gctctgtca  gcacttcga  tcactagct  tcatagaca  ccctggagc  gatactctg  300
ataaattat  tgaccatgc  gtagccaag  ttgggaaga  ggacagcct  gggacccgg  360
agatcctga  cgaagaaaa  gaaatgcag  caaatggaa  ggtttttaa  aagttaatt  420
ttgggaatt  taaatggat  aactatctt  aagtgaact  ccgagtgaa  aactttgga  480
gtggcctca  tgcactggg  ctgaaacca  agaacacca  tgccatttt  tgtgagacc  540
gggcggagt  gatgattgc  gcgcagacc  gctttaagt  caactttcc  cttgtgact  600
tatatgcta  ccttggcaa  gaagctgtc  ttcatggat  aaatgagtc  gaggcttcc  660
atctgatta  tagtgttga  cttctggaa  gcaaactga  ggcggcatt  ttagatatc  720
attgtgtta  acatatcat  tatgtggat  acaagacta  caatagagc  gagtacccc  780
aggggcttg  gattcacag  atgcagtca  tagaggagc  gggatccaa  ccagaaaac  840
caagcattc  tccaagtag  ccaactcct  cggacatgg  cattgtcat  tacaccagt  900
gctctactg  ccgccccaa  ggagtgatg  tgcaccata  caatctgat  gctgggatg  960
caggccagt  tgagcgcat  cctggatta  gaccaaagg  cacatatat  ggctactta  1020
ctttggctc  tgtgctgga  ctgacagca  agatctcct  ctttaccta  ggctgtagg  1080
ttggatatt  gtcaccact  acactgtct  accagtcca  caaaatcaa  aagggaagc  1140
agggtgatt  tactgtact  aaacctaca  ttatggcgg  cgttccgga  atcatggat  1200
gaatttaca  gaatgttat  agcaaggtt  aagagatga  ttatattca  aagactcta  1260
ttaaaattg  gtatgatta  aaattagag  aaatcaaga  aggatatga  gcccctctt  1320
gtaatctga  actgtttaa  aaggtgaag  ctcttctag  aggaaatgt  cgcatgatg  1380
tgtccggcg  tgccccact  tccccccag  cacaccgat  catgaatgt  tgcttctgc  1440
gccccattg  tcagggcta  gggctgaca  aatcatgcg  tgctggaac  gttactgaa  1500
ttaccgact  cactactgg  agagttggc  ctcctctta  ttgctgtga  attaaactg  1560
aggactggc  ggaaggtgg  tatacagtt  atgataagc  aaaccccag  ggtgaaatt  1620
tgattggag  ccagaatat  tccatggga  attttaaaa  tgaagagaa  acagcagaa  1680
attattctg  ggatgaaaa  ggacaaagg  ggttttgca  tggtgatat  ggagaattc  1740
accctgatg  atgcttaca  attatcgat  gtaagaaag  tctggtgaa  ctgcaagcc  1800
gagagtacg  gtctcttgg  aaagtcgaa  ccgcactga  gaattgtcc  ctgatcgac  1860
acatctgtg  ttttgccaa  agtgaccag  cttatgtga  cagttttgt  gttcccaac  1920
agaaaaagt  gactctttt  gcacaacag  agggggtag  aggatcttg  gttgatatt  1980
gcaataatc  tgccatgga  gctgaaata  tgaaagaaa  tcgagaagc  gcaaatgcc  2040
tgaaattgg  acgatttga  attccaatc  aagttcgat  gagcccaga  ccatggacc  2100
ctgaaactg  tttggtaac  gatgccttc  agctgaaaa  gaaggaact  aagaaccat  2160
atcttaaag  cattgagcg  atgtatggg  gcaaataaa  ggcaactgt  tacttcaca  2220
ttgcacagg  ggtggcctg  tggtttttt  agttctaga  tttaagcct  tgttgatct  2280
tctgttaaa  tgtaaggtg  atcttctaa  gacatgaaa  aaaaaaaca  ccaaaagtg  2340
ttacaataa  ttgcatagt  ctagagaag  tgaaattga  gacatttcc  tttagctgt  2400
ttattaagt  tagagcaaa  attctgttt  agaatatta  ccttagcta  acttgtttt  2460
ctaaagata  tccatgcta  agtaaacaa  ttggacttg  actaggtgt  gttgaagaa  2520
tctacagct  ccagtgtct  tgtcttcct  gttcagaag  ttctatcgt  atcattagg  2580
caaaattac  tattaacac  actcaaagc  gaagttcca  caggctttg  aatcctctt  2640
caaccattt  tcttgaagg  aaaaaaatc  gttgtaata  atggattca  tatcttaga  2700
ggtattatt  taagctcat  attgccatg  aggtgagac  tagaatcat  ataatattg  2760
gaataatta  agtgcctga  gttaaaact  aaacaacac  cacatacca  aaatatctc  2820
taatgtatt  gaagggagg  tgaattgct  ctttggatg  ctaagaact  aaatcagca  2880
ctgtaatta  tgaaatgtc  tcagaaaaa  gtccacttt  taaaagtga  ctttctgtg  2940
gtgatctag  caaaggctg  gaccaaggg  aacatgtta  aaagtcaat  agaattcaa  3000
aagatacat  gcttttctg  tagaaagtt  atggcatcc  aagcattca  aattaggat  3060
ctggcatag  actgagcct  ggaaagaga  ttagcctct  taactttga  accagggct  3120
gattttaaa  tgtgcttgt  ttaaattac  tttgtaatt  atggtctgt  tgctgttgc  3180
gattgattc  tgatcagta  tgtgcattt  agagagcct  tcattttgc  ttaatttca  3240
caaagcggg  tatgataaa  gacttcctc  aatcttgtt  aaacctacg  gtgattaag  3300
gtcttggat  agtctgagg  agttaaagg  aagaaaaca  tgttaacac  tttcctgtt  3360
gtgaagagt  tagaaactg  aaatgctag  tttgggaga  gggcagagt  acttgatta  3420
ggactgtct  tgcagtaac  tgggagtgt  agtttcttt  taaatcttc  gctaaaatc  3480
ggaattata  attcttgat  gatattcgc  cttgaacca  agttactgt  tgtaaaaag  3540
aaaaattct  aatactgtt  ttctttgca  ttttttcat  gtcatttta  acacacaca  3600
acacacatg  atgtgtatg  gtgtgtgta  atataatat  tatatgttg  ttacattgt  3660
ttgtacaga  gtgggccac  actacaaca  aatgagttc  ttgtgctct  aaatattta  3720
aaagaaatt  tttaaatgt  atgtatatg  tggtaatat  gagaaaaaa  atcatctgg  3780
attctgagc  acagcgaag  tttttgtaa  agtttcttt  cagtgttgt  caaactaaa  3840
tttgaggca  gttttccct  aagttctat  tgagtattc  catgcttcc  atcttgcct  3900
tgaagtgtg  aaagacatc  agtagacta  tagtcagct  ctacctact  ctagtgcac  3960
gtttatccg  tttttttta  aggcttttc  aatatatgt  tcccatttg  aatggtgat  4020
ttaaaatgt  agtgcatgc  gactatctt  cttaagata  ttgcacccc  cccacagcc  4080
tctcccaaa  ctggaacac  gccaactag  tccttaaga  tcacgcatt  aatacaagg  4140
cgggtgctg  taattcttc  tgaaaatcc  aacacacac  ttaagggac  agggagatg  4200
cactgccct  tgacttttc  tcaaaaaaa  aatatatat  tacatgttt  tgtaaacag  4260
actattttc  atattcata  tgacttttt  agtatttga  cctaaaggt  ttgatctcc  4320
ttttatacc  atttaaatc  ttcacaatt  catgtcagc  atcaattaa  gctgtgctt  4380
ctgttgatt  tgtgtgcat  tctaaggtg  acgctccta  ttttttgct  taattacat  4440
aaagggtct  atttctttg  tatttgtgc  ctttttttt  atgtagact  aaggtatga  4500
tgtgtgact  ttaagaaat  aaataccga  gaatgatcc  tagagtcca  agtgaggga  4560
aatgctgtt  ctttgttca  agagactga  tagtaatct  tgcctatat  ttcctggta  4620
cagatgaca  atgtttcta  agtgacaag  tgagaagag  ttaaaggtt  aagattgtg  4680
ggcattcgg  aactggaga  atacgtttt  attttgaat  tagttacaa  ttttatatt  4740
atatttgta  tttctgtta  tgcacgatt  tagaattgt  ctgtagatt  tttgtgttt  4800
ctcttgaaa  gctttgttt  ttcttcttt  taagtttgc  cttgaatct  ataaaataa  4860
tc  4862



<210> 2223
<211> 670
<212> PRT
<213> Rattus norvegicus
<308> O35547
<400> 2223

Met Ala Lys Arg Ile Lys Ala Lys Pro Thr Ser Asp Lys Pro Gly Ser 
  1               5                  10                  15
Pro Tyr Arg Ser Val Thr His Phe Asp Ser Leu Ala Val Ile Asp Ile 
             20                  25                  30
Pro Gly Ala Asp Thr Leu Asp Lys Leu Phe Asp His Ala Val Ala Lys 
         35                  40                  45
Phe Gly Lys Lys Asp Ser Leu Gly Thr Arg Glu Ile Leu Ser Glu Glu 
     50                  55                  60
Asn Glu Met Gln Pro Asn Gly Lys Val Phe Lys Lys Leu Ile Leu Gly 
 65                  70                  75                  80
Asn Tyr Lys Trp Ile Asn Tyr Leu Glu Val Asn Cys Arg Val Asn Asn 
                 85                  90                  95
Phe Gly Ser Gly Leu Thr Ala Leu Gly Leu Lys Pro Lys Asn Thr Ile 
             100                105                110
Ala Ile Phe Cys Glu Thr Arg Ala Glu Trp Met Ile Ala Ala Gln Thr 
         115                120                125
Cys Phe Lys Tyr Asn Phe Pro Leu Val Thr Leu Tyr Ala Thr Leu Gly 
     130                135                140
Lys Glu Ala Val Val His Gly Leu Asn Glu Ser Glu Ala Ser Tyr Leu 
 145                150                155                160
Ile Thr Ser Val Glu Leu Leu Glu Ser Lys Leu Lys Ala Ala Leu Leu 
                 165                170                175
Asp Ile Asn Cys Val Lys His Ile Ile Tyr Val Asp Asn Lys Thr Ile 
             180                185                190
Asn Arg Ala Glu Tyr Pro Glu Gly Leu Glu Ile His Ser Met Gln Ser 
         195                200                205
Val Glu Glu Leu Gly Ser Lys Pro Glu Asn Ser Ser Ile Pro Pro Ser 
     210                215                220
Arg Pro Thr Pro Ser Asp Met Ala Ile Val Met Tyr Thr Ser Gly Ser 
 225                230                235                240
Thr Gly Arg Pro Lys Gly Val Met Met His His Ser Asn Leu Ile Ala 
                 245                250                255
Gly Met Thr Gly Gln Cys Glu Arg Ile Pro Gly Leu Gly Pro Lys Asp 
             260                265                270
Thr Tyr Ile Gly Tyr Leu Pro Leu Ala His Val Leu Glu Leu Thr Ala 
         275                280                285
Glu Ile Ser Cys Phe Thr Tyr Gly Cys Arg Ile Gly Tyr Ser Ser Pro 
     290                295                300
Leu Thr Leu Ser Asp Gln Ser Ser Lys Ile Lys Lys Gly Ser Lys Gly 
 305                310                315                320
Asp Cys Thr Val Leu Lys Pro Thr Leu Met Ala Ala Val Pro Glu Ile 
                 325                330                335
Met Asp Arg Ile Tyr Lys Asn Val Met Ser Lys Val Gln Glu Met Asn 
             340                345                350
Tyr Ile Gln Lys Thr Leu Phe Lys Ile Gly Tyr Asp Tyr Lys Leu Glu 
         355                360                365
Gln Ile Lys Lys Gly Tyr Asp Ala Pro Leu Cys Asn Leu Ile Leu Phe 
     370                375                380
Lys Lys Val Lys Ala Leu Leu Gly Gly Asn Val Arg Met Met Leu Ser 
 385                390                395                400
Gly Gly Ala Pro Leu Ser Pro Gln Thr His Arg Phe Met Asn Val Cys 
                 405                410                415
Phe Cys Cys Pro Ile Gly Gln Gly Tyr Gly Leu Thr Glu Ser Cys Gly 
             420                425                430
Ala Gly Thr Val Thr Glu Val Thr Asp Tyr Thr Thr Gly Arg Val Gly 
         435                440                445
Ala Pro Leu Ile Cys Cys Glu Ile Lys Leu Lys Asp Trp Gln Glu Gly 
     450                455                460
Gly Tyr Thr Val His Asp Lys Pro Asn Pro Arg Gly Glu Ile Val Ile 
 465                470                475                480
Gly Gly Gln Asn Ile Ser Met Gly Tyr Phe Lys Asn Glu Glu Lys Thr 
                 485                490                495
Ala Glu Asp Tyr Ser Val Asp Glu Asn Gly Gln Arg Trp Phe Cys Thr 
             500                505                510
Gly Asp Ile Gly Glu Phe His Pro Asp Gly Cys Leu Gln Ile Ile Asp 
         515                520                525
Arg Lys Lys Asp Leu Val Lys Leu Gln Ala Gly Glu Tyr Val Ser Leu 
     530                535                540
Gly Lys Val Glu Ala Ala Leu Lys Asn Cys Pro Leu Ile Asp Asn Ile 
 545                550                555                560
Cys Ala Phe Ala Lys Ser Asp Gln Ser Tyr Val Ile Ser Phe Val Val 
                 565                570                575
Pro Asn Gln Lys Lys Leu Thr Leu Leu Ala Gln Gln Lys Gly Val Glu 
             580                585                590
Gly Ser Trp Val Asp Ile Cys Asn Asn Pro Ala Met Glu Ala Glu Ile 
         595                600                605
Leu Lys Glu Ile Arg Glu Ala Ala Asn Ala Met Lys Leu Glu Arg Phe 
     610                615                620
Glu Ile Pro Ile Lys Val Arg Leu Ser Pro Glu Pro Trp Thr Pro Glu 
 625                630                635                640
Thr Gly Leu Val Thr Asp Ala Phe Lys Leu Lys Arg Lys Glu Leu Lys 
                 645                650                655
Asn His Tyr Leu Lys Asp Ile Glu Arg Met Tyr Gly Gly Lys 
             660                665                670



<210> 2224
<211> 5356
<212> DNA
<213> Homo sapiens
<308> NM_022977
<400> 2224

cgggattcg  ctggctctg  cacaccacc  cgcgccccc  ctccgcccg  ccctccggg  60
gcgtctttt  cgggctcgc  ctgagtccc  cctccgccg  ctgtccggg  gcgcgcgcg  120
cgctgcggc  ttttctctg  cctccgccg  gcgctcctc  tcgtcccag  gctagcggg  180
acgcggttc  tttttgcga  ctttccgag  gccaggcgc  ggccggctg  gaagacgcg  240
tgggccgcc  ctccgattg  aatcacaga  gatattcgt  ttcttctta  gagaaaaag  300
ggacatttt  gctttctca  ttgaaggcg  actttattg  cggcttcca  agattacta  360
cttttatct  tatcactaa  attgaactg  cttggctgt  ctgctattc  tactgctgc  420
tctattatt  ccttcttca  cacaataag  ctttcaaaa  ccaaagaat  acaagaaat  480
agcaccatt  tagaagcct  tccactatg  aacttaagc  aaatgtgct  accattatt  540
tgctgcctg  ccacttgtt  ataacaata  acagtgccc  tatatttat  ccatggtat  600
ttcttacca  tgccaagaa  aaaaacgct  tggcaaaga  aataaaagc  aagcccact  660
cagacaaac  tggaagtcc  tatcgctct  tcacacact  cgactcact  gctgtaata  720
acatccctg  agcagatac  ctggataaa  tatttgacc  tgctgtatc  aagtttggg  780
agaaggaca  ccttgggac  agggaaatc  taagtgaag  aaatgaaat  cagccaaat  840
gaaaagttt  taagaagtt  attcttggg  attataaat  gatgaacta  cttgaagtg  900
atcgcagag  gaataactt  ggtagtgga  tcactgcac  gggactaaa  ccaaagaac  960
ccattgcca  cttctgtga  accagggcc  aatggatga  tgcagcaca  acctgcttt  1020
agtacaact  tcctcttgt  actttatat  ccacacttg  caaagaagc  gtagttcat  1080
ggctaaatg  atctgaggc  tcctatctg  ttaccagtg  tgaacttct  gaaagtaaa  1140
ttaagactg  attgttaga  atcagttgt  ttaaacata  catttatgt  gacaataag  1200
ctatcaata  agcagagta  cctgaagga  ttgagattc  cagcatgca  tcagtagaa  1260
agttgggat  taacccaga  aacttgggc  ttcctccaa  tagaccaac  ccttcagac  1320
tggccattg  tatgtatac  agtggttct  ctggccgac  taagggagt  atgatgcat  1380
atagcaatt  gatagctgg  atgacaggc  agtgtgaaa  aatacctgg  ctgggaccg  1440
aggacacat  tattggcta  ttgcctttg  ctcatgtgc  agaactgac  gcagagata  1500
cttgcttta  ctatggctg  aggattgga  attcttctc  gcttacact  tctgaccag  1560
ccagcaaaa  taaaaaagg  agcaaagga  actgtactg  actgaagcc  acacttatg  1620
ctgctgttc  ggaaatcat  gatagaatt  ataagaatg  tatgagcaa  gtccaagag  1680
tgaattata  tcagaaaac  ctgttcaag  tagggtatg  ttacaaatt  gaacagatc  1740
aaaagggat  tgatgcacc  ctttgcaat  tgttactgt  taaaaaggt  aaggccctg  1800
tgggaggga  tgtccgcat  atgctgtct  gaggggccc  gctatctcc  cagacacac  1860
gattcatga  tgtctgctt  tgctgccca  ttggccagg  ttatggact  acagaatca  1920
gtggtgctg  gacagttac  gaagtaact  actatacta  tggcagagt  ggagcacct  1980
ttatttgct  tgaaattaa  ctaaaagac  ggcaagaag  cggttatac  attaatgac  2040
agccaaacc  cagaggtga  atcgtaatt  gtggacaga  catctccat  ggatatttt  2100
aaaatgaag  gaaaacagc  gaagattat  ctgtggatg  aaatggaca  aggtggttt  2160
gcactggtg  tattggaga  ttccatccc  atggatgtt  acagattat  gatcgtaag  2220
aagatctag  gaagttaca  gcaggagag  atgtatctc  tgggaaagt  gaagctgca  2280
tgaagaatt  tccacttat  gacaacatc  gtgcttttg  caaaagtga  cagtcctat  2340
tgatcagtt  tgtggttcc  aaccagaaa  ggttgacac  tttggcaca  cagaaaggg  2400
tagaaggaa  ttgggttga  atctgcaat  atcctgcta  ggaagctga  atactgaaa  2460
aaattcgag  agctgcaaa  gccatgaaa  tggagcgat  tgaaattcc  atcaaggtt  2520
gattaagcc  agagccatg  acccctgaa  ctggtttgg  aactgatgc  ttcaaactg  2580
aaaggaagg  gctgaggaa  cattacctc  aagacattg  acgaatgta  gggggcaaa  2640
aaaatgttg  tgtcttatt  acagttgtg  aggaggtag  ctggtggtt  tcaacctct  2700
gaattttaa  cctttgttg  actgttaga  tgtaaggta  atcattcta  agatagagt  2760
aaaagaaaa  aaaaccaaa  gttattaaa  ttgttgtcc  gtttacttt  acttagttt  2820
gcatagttc  agtgcagct  aaattgaaa  gttatttcc  tttagctgt  ttattatag  2880
gcagaaatt  tgtttttaa  aattagcct  agatatact  gtttttgta  agaaaaata  2940
ttaatgttg  acaaaataa  ttggagttg  agtagaatg  agtttgagg  aatttgcag  3000
ttccaatgc  tcttgtctt  ctatttcag  agtttaaat  ttaagcatg  cagaaaata  3060
gtattaaca  tactcaaag  aaaagtgct  cagggcttt  aaattctct  ccaaccatt  3120
atcttgaag  aaaaattca  tagtaatat  atacacaaa  tcaaataat  ccttagaag  3180
tattaagat  ataattgtt  cataggtta  atatagagt  attgtaatg  tgtgaataa  3240
tacagtgcc  aaaataaga  tagaacaac  tatacaaca  caaaaaata  ctagtaata  3300
atttaaagg  aaattgagc  gcttttttt  aaactttga  atctaaaaa  aactgtaat  3360
atttgaatg  ctaagagga  agtacattt  ttgaaatgc  gaaaattgc  tttctgtgt  3420
tattcaaac  gaaaagctg  gaccaagag  aaggaaggt  aaaagttaa  aggcaaaca  3480
tttctctta  aaaaggtga  aaaatcata  gtatttgga  ttagaaccc  tgcacagca  3540
tgaacctgg  aaagagatt  aaactctga  tttatcttt  ataacaggg  ttgatttta  3600
aatgtacat  tattaaatt  catttgtaa  ttaaggtct  tttgctgtt  ctgatttta  3660
tcttgatca  tagtttgca  ttcagaaag  ctttcattt  gctttaagt  tagcaaagc  3720
gggttataa  gaatgactt  cccaatatc  tgcttgaac  tacagtgat  aacttggat  3780
agttttggg  agttaaagg  aagaaaaca  tgttatcat  ttttcctgt  tgggaagag  3840
ttagaaact  gaaatacta  atttgggag  agggcagag  tacttgata  gggacttga  3900
gtttgtgca  taacttggg  gtgtggttt  tttttgaat  tttaattaa  acctgggat  3960
atatatccc  gataaatat  cacacttga  ccatagtta  tgtaaaatg  aaaaaatct  4020
aatactgtt  ttctttgca  tttttctta  tcatttttt  tatatatgc  tatatatat  4080
tgtgtgtgt  tgttgctta  gttgttttg  acagatgtg  gccaccatt  caacaaaat  4140
cattctttt  gctctaaaa  atttatgaa  aaaatactt  aatgttatg  atatggtgg  4200
aataaggga  aaatcaagt  ttataaaca  gaatgaagg  ttttgtaaa  atttctgtt  4260
agcgttttg  aaggtaaaa  tttaggcaa  ttttccctg  agttatgtg  atgtgagta  4320
tctcattct  cccaacttg  ctttgaaga  tgaaatacc  ttattatca  gtagactac  4380
gttcagctt  tattccttc  ctggttgtt  atcccttag  aatgagttt  ttagacttt  4440
ccaatatgt  atttttttt  ccatttaga  tggtgattt  aaatgtgtg  gtgcatgta  4500
tatcttatc  cagatattt  cacccccaa  ctgccccca  ctcccaaaa  ctagaacac  4560
gccaactga  ctgttatag  tcctttaga  acacataat  aacacttaa  gttgggtgc  4620
gctaattct  tgcaaaaat  caaatattg  taagggacc  gggagatgc  actacccct  4680
gattttcca  ctaaaaata  acatgttta  gtaaacaaa  ctttccata  ccatagtga  4740
ttttcaagt  tttaagcct  aagattttg  tctcacatt  ttatacctg  ttaaattgc  4800
cacagttat  acatacaca  cagccatca  ctaaagttg  actttaaaa  tttactaca  4860
tatgtacat  tctaagtca  acacttgtg  cttttgctt  aattccatg  atgttcctg  4920
ctccttgat  tttgtattt  ttctttttt  ctctagagt  gaggtataa  tgtgtgata  4980
ttcagaaat  cagataaat  attcaaaaa  tcacagtta  ggagaatca  gtttctttg  5040
tcatgaata  ctgattagt  agtcttgcc  atattttcc  gatagcata  gacaaatgt  5100
tctaaggta  caagatgag  acagataaa  attgtgtgg  gttttggat  tggagagaa  5160
tattttaat  tttaaatgc  gttacaaat  ataatgtat  catatttgt  ctttctgtt  5220
aaatgcatg  ttgcagaat  gtttagatt  tgtgtttat  cttgatgaa  agctttgtt  5280
gttcttgtt  ttaagtttg  actcaaatc  taagaaata  atccaccca  gttatcaaa  5340
aaaaaaaaa  aaaaaa  5356



<210> 2225
<211> 711
<212> PRT
<213> Homo sapiens
<308> O60488
<400> 2225

Met Lys Leu Lys Leu Asn Val Leu Thr Ile Ile Leu Leu Pro Val His 
  1               5                  10                  15
Leu Leu Ile Thr Ile Tyr Ser Ala Leu Ile Phe Ile Pro Trp Tyr Phe 
             20                  25                  30
Leu Thr Asn Ala Lys Lys Lys Asn Ala Met Ala Lys Arg Ile Lys Ala 
         35                  40                  45
Lys Pro Thr Ser Asp Lys Pro Gly Ser Pro Tyr Arg Ser Val Thr His 
     50                  55                  60
Phe Asp Ser Leu Ala Val Ile Asp Ile Pro Gly Ala Asp Thr Leu Asp 
 65                  70                  75                  80
Lys Leu Phe Asp His Ala Val Ser Lys Phe Gly Lys Lys Asp Ser Leu 
                 85                  90                  95
Gly Thr Arg Glu Ile Leu Ser Glu Glu Asn Glu Met Gln Pro Asn Gly 
             100                105                110
Lys Val Phe Lys Lys Leu Ile Leu Gly Asn Tyr Lys Trp Met Asn Tyr 
         115                120                125
Leu Glu Val Asn Arg Arg Val Asn Asn Phe Gly Ser Gly Leu Thr Ala 
     130                135                140
Leu Gly Leu Lys Pro Lys Asn Thr Ile Ala Ile Phe Cys Glu Thr Arg 
 145                150                155                160
Ala Glu Trp Met Ile Ala Ala Gln Thr Cys Phe Lys Tyr Asn Phe Pro 
                 165                170                175
Leu Val Thr Leu Tyr Ala Thr Leu Gly Lys Glu Ala Val Val His Gly 
             180                185                190
Leu Asn Glu Ser Glu Ala Ser Tyr Leu Ile Thr Ser Val Glu Leu Leu 
         195                200                205
Glu Ser Lys Leu Lys Thr Ala Leu Leu Asp Ile Ser Cys Val Lys His 
     210                215                220
Ile Ile Tyr Val Asp Asn Lys Ala Ile Asn Lys Ala Glu Tyr Pro Glu 
 225                230                235                240
Gly Phe Glu Ile His Ser Met Gln Ser Val Glu Glu Leu Gly Ser Asn 
                 245                250                255
Pro Glu Asn Leu Gly Ile Pro Pro Ser Arg Pro Thr Pro Ser Asp Met 
             260                265                270
Ala Ile Val Met Tyr Thr Ser Gly Ser Thr Gly Arg Pro Lys Gly Val 
         275                280                285
Met Met His His Ser Asn Leu Ile Ala Gly Met Thr Gly Gln Cys Glu 
     290                295                300
Arg Ile Pro Gly Leu Gly Pro Lys Asp Thr Tyr Ile Gly Tyr Leu Pro 
 305                310                315                320
Leu Ala His Val Leu Glu Leu Thr Ala Glu Ile Ser Cys Phe Thr Tyr 
                 325                330                335
Gly Cys Arg Ile Gly Tyr Ser Ser Pro Leu Thr Leu Ser Asp Gln Ser 
             340                345                350
Ser Lys Ile Lys Lys Gly Ser Lys Gly Asp Cys Thr Val Leu Lys Pro 
         355                360                365
Thr Leu Met Ala Ala Val Pro Glu Ile Met Asp Arg Ile Tyr Lys Asn 
     370                375                380
Val Met Ser Lys Val Gln Glu Met Asn Tyr Ile Gln Lys Thr Leu Phe 
 385                390                395                400
Lys Ile Gly Tyr Asp Tyr Lys Leu Glu Gln Ile Lys Lys Gly Tyr Asp 
                 405                410                415
Ala Pro Leu Cys Asn Leu Leu Leu Phe Lys Lys Val Lys Ala Leu Leu 
             420                425                430
Gly Gly Asn Val Arg Met Met Leu Ser Gly Gly Ala Pro Leu Ser Pro 
         435                440                445
Gln Thr His Arg Phe Met Asn Val Cys Phe Cys Cys Pro Ile Gly Gln 
     450                455                460
Gly Tyr Gly Leu Thr Glu Ser Cys Gly Ala Gly Thr Val Thr Glu Val 
 465                470                475                480
Thr Asp Tyr Thr Thr Gly Arg Val Gly Ala Pro Leu Ile Cys Cys Glu 
                 485                490                495
Ile Lys Leu Lys Asp Trp Gln Glu Gly Gly Tyr Thr Ile Asn Asp Lys 
             500                505                510
Pro Asn Pro Arg Gly Glu Ile Val Ile Gly Gly Gln Asn Ile Ser Met 
         515                520                525
Gly Tyr Phe Lys Asn Glu Glu Lys Thr Ala Glu Asp Tyr Ser Val Asp 
     530                535                540
Glu Asn Gly Gln Arg Trp Phe Cys Thr Gly Asp Ile Gly Glu Phe His 
 545                550                555                560
Pro Asp Gly Cys Leu Gln Ile Ile Asp Arg Lys Lys Asp Leu Val Lys 
                 565                570                575
Leu Gln Ala Gly Glu Tyr Val Ser Leu Gly Lys Val Glu Ala Ala Leu 
             580                585                590
Lys Asn Cys Pro Leu Ile Asp Asn Ile Cys Ala Phe Ala Lys Ser Asp 
         595                600                605
Gln Ser Tyr Val Ile Ser Phe Val Val Pro Asn Gln Lys Arg Leu Thr 
     610                615                620
Leu Leu Ala Gln Gln Lys Gly Val Glu Gly Thr Trp Val Asp Ile Cys 
 625                630                635                640
Asn Asn Pro Ala Met Glu Ala Glu Ile Leu Lys Glu Ile Arg Glu Ala 
                 645                650                655
Ala Asn Ala Met Lys Leu Glu Arg Phe Glu Ile Pro Ile Lys Val Arg 
             660                665                670
Leu Ser Pro Glu Pro Trp Thr Pro Glu Thr Gly Leu Val Thr Asp Ala 
         675                680                685
Phe Lys Leu Lys Arg Lys Glu Leu Arg Asn His Tyr Leu Lys Asp Ile 
     690                695                700
Glu Arg Met Tyr Gly Gly Lys 
 705                710



<210> 2226
<211> 4862
<212> DNA
<213> Rattus norvegicus
<308> D85189
<400> 2226

gccgaggct  gcccctcct  gcaaggctg  tccagagct  gcgggcacg  gagctcctc  60
ccgggagct  ccttccccg  aaggccggg  cccagtggc  gactcgtgg  gagcgaggc  120
gcaccttcg  tcccaggag  ttgacctgt  cttaaaagt  aaagaagaa  tctaagaaa  180
acgctatgg  aaagagaat  aaagctaag  ccacttcag  caaacccgg  agtccatat  240
gctctgtca  gcacttcga  tcactagct  tcatagaca  ccctggagc  gatactctg  300
ataaattat  tgaccatgc  gtagccaag  ttgggaaga  ggacagcct  gggacccgg  360
agatcctga  cgaagaaaa  gaaatgcag  caaatggaa  ggtttttaa  aagttaatt  420
ttgggaatt  taaatggat  aactatctt  aagtgaact  ccgagtgaa  aactttgga  480
gtggcctca  tgcactggg  ctgaaacca  agaacacca  tgccatttt  tgtgagacc  540
gggcggagt  gatgattgc  gcgcagacc  gctttaagt  caactttcc  cttgtgact  600
tatatgcta  ccttggcaa  gaagctgtc  ttcatggat  aaatgagtc  gaggcttcc  660
atctgatta  tagtgttga  cttctggaa  gcaaactga  ggcggcatt  ttagatatc  720
attgtgtta  acatatcat  tatgtggat  acaagacta  caatagagc  gagtacccc  780
aggggcttg  gattcacag  atgcagtca  tagaggagc  gggatccaa  ccagaaaac  840
caagcattc  tccaagtag  ccaactcct  cggacatgg  cattgtcat  tacaccagt  900
gctctactg  ccgccccaa  ggagtgatg  tgcaccata  caatctgat  gctgggatg  960
caggccagt  tgagcgcat  cctggatta  gaccaaagg  cacatatat  ggctactta  1020
ctttggctc  tgtgctgga  ctgacagca  agatctcct  ctttaccta  ggctgtagg  1080
ttggatatt  gtcaccact  acactgtct  accagtcca  caaaatcaa  aagggaagc  1140
agggtgatt  tactgtact  aaacctaca  ttatggcgg  cgttccgga  atcatggat  1200
gaatttaca  gaatgttat  agcaaggtt  aagagatga  ttatattca  aagactcta  1260
ttaaaattg  gtatgatta  aaattagag  aaatcaaga  aggatatga  gcccctctt  1320
gtaatctga  actgtttaa  aaggtgaag  ctcttctag  aggaaatgt  cgcatgatg  1380
tgtccggcg  tgccccact  tccccccag  cacaccgat  catgaatgt  tgcttctgc  1440
gccccattg  tcagggcta  gggctgaca  aatcatgcg  tgctggaac  gttactgaa  1500
ttaccgact  cactactgg  agagttggc  ctcctctta  ttgctgtga  attaaactg  1560
aggactggc  ggaaggtgg  tatacagtt  atgataagc  aaaccccag  ggtgaaatt  1620
tgattggag  ccagaatat  tccatggga  attttaaaa  tgaagagaa  acagcagaa  1680
attattctg  ggatgaaaa  ggacaaagg  ggttttgca  tggtgatat  ggagaattc  1740
accctgatg  atgcttaca  attatcgat  gtaagaaag  tctggtgaa  ctgcaagcc  1800
gagagtacg  gtctcttgg  aaagtcgaa  ccgcactga  gaattgtcc  ctgatcgac  1860
acatctgtg  ttttgccaa  agtgaccag  cttatgtga  cagttttgt  gttcccaac  1920
agaaaaagt  gactctttt  gcacaacag  agggggtag  aggatcttg  gttgatatt  1980
gcaataatc  tgccatgga  gctgaaata  tgaaagaaa  tcgagaagc  gcaaatgcc  2040
tgaaattgg  acgatttga  attccaatc  aagttcgat  gagcccaga  ccatggacc  2100
ctgaaactg  tttggtaac  gatgccttc  agctgaaaa  gaaggaact  aagaaccat  2160
atcttaaag  cattgagcg  atgtatggg  gcaaataaa  ggcaactgt  tacttcaca  2220
ttgcacagg  ggtggcctg  tggtttttt  agttctaga  tttaagcct  tgttgatct  2280
tctgttaaa  tgtaaggtg  atcttctaa  gacatgaaa  aaaaaaaca  ccaaaagtg  2340
ttacaataa  ttgcatagt  ctagagaag  tgaaattga  gacatttcc  tttagctgt  2400
ttattaagt  tagagcaaa  attctgttt  agaatatta  ccttagcta  acttgtttt  2460
ctaaagata  tccatgcta  agtaaacaa  ttggacttg  actaggtgt  gttgaagaa  2520
tctacagct  ccagtgtct  tgtcttcct  gttcagaag  ttctatcgt  atcattagg  2580
caaaattac  tattaacac  actcaaagc  gaagttcca  caggctttg  aatcctctt  2640
caaccattt  tcttgaagg  aaaaaaatc  gttgtaata  atggattca  tatcttaga  2700
ggtattatt  taagctcat  attgccatg  aggtgagac  tagaatcat  ataatattg  2760
gaataatta  agtgcctga  gttaaaact  aaacaacac  cacatacca  aaatatctc  2820
taatgtatt  gaagggagg  tgaattgct  ctttggatg  ctaagaact  aaatcagca  2880
ctgtaatta  tgaaatgtc  tcagaaaaa  gtccacttt  taaaagtga  ctttctgtg  2940
gtgatctag  caaaggctg  gaccaaggg  aacatgtta  aaagtcaat  agaattcaa  3000
aagatacat  gcttttctg  tagaaagtt  atggcatcc  aagcattca  aattaggat  3060
ctggcatag  actgagcct  ggaaagaga  ttagcctct  taactttga  accagggct  3120
gattttaaa  tgtgcttgt  ttaaattac  tttgtaatt  atggtctgt  tgctgttgc  3180
gattgattc  tgatcagta  tgtgcattt  agagagcct  tcattttgc  ttaatttca  3240
caaagcggg  tatgataaa  gacttcctc  aatcttgtt  aaacctacg  gtgattaag  3300
gtcttggat  agtctgagg  agttaaagg  aagaaaaca  tgttaacac  tttcctgtt  3360
gtgaagagt  tagaaactg  aaatgctag  tttgggaga  gggcagagt  acttgatta  3420
ggactgtct  tgcagtaac  tgggagtgt  agtttcttt  taaatcttc  gctaaaatc  3480
ggaattata  attcttgat  gatattcgc  cttgaacca  agttactgt  tgtaaaaag  3540
aaaaattct  aatactgtt  ttctttgca  ttttttcat  gtcatttta  acacacaca  3600
acacacatg  atgtgtatg  gtgtgtgta  atataatat  tatatgttg  ttacattgt  3660
ttgtacaga  gtgggccac  actacaaca  aatgagttc  ttgtgctct  aaatattta  3720
aaagaaatt  tttaaatgt  atgtatatg  tggtaatat  gagaaaaaa  atcatctgg  3780
attctgagc  acagcgaag  tttttgtaa  agtttcttt  cagtgttgt  caaactaaa  3840
tttgaggca  gttttccct  aagttctat  tgagtattc  catgcttcc  atcttgcct  3900
tgaagtgtg  aaagacatc  agtagacta  tagtcagct  ctacctact  ctagtgcac  3960
gtttatccg  tttttttta  aggcttttc  aatatatgt  tcccatttg  aatggtgat  4020
ttaaaatgt  agtgcatgc  gactatctt  cttaagata  ttgcacccc  cccacagcc  4080
tctcccaaa  ctggaacac  gccaactag  tccttaaga  tcacgcatt  aatacaagg  4140
cgggtgctg  taattcttc  tgaaaatcc  aacacacac  ttaagggac  agggagatg  4200
cactgccct  tgacttttc  tcaaaaaaa  aatatatat  tacatgttt  tgtaaacag  4260
actattttc  atattcata  tgacttttt  agtatttga  cctaaaggt  ttgatctcc  4320
ttttatacc  atttaaatc  ttcacaatt  catgtcagc  atcaattaa  gctgtgctt  4380
ctgttgatt  tgtgtgcat  tctaaggtg  acgctccta  ttttttgct  taattacat  4440
aaagggtct  atttctttg  tatttgtgc  ctttttttt  atgtagact  aaggtatga  4500
tgtgtgact  ttaagaaat  aaataccga  gaatgatcc  tagagtcca  agtgaggga  4560
aatgctgtt  ctttgttca  agagactga  tagtaatct  tgcctatat  ttcctggta  4620
cagatgaca  atgtttcta  agtgacaag  tgagaagag  ttaaaggtt  aagattgtg  4680
ggcattcgg  aactggaga  atacgtttt  attttgaat  tagttacaa  ttttatatt  4740
atatttgta  tttctgtta  tgcacgatt  tagaattgt  ctgtagatt  tttgtgttt  4800
ctcttgaaa  gctttgttt  ttcttcttt  taagtttgc  cttgaatct  ataaaataa  4860
tc  4862



<210> 2227
<211> 670
<212> PRT
<213> Rattus norvegicus
<308> O35547
<400> 2227

Met Ala Lys Arg Ile Lys Ala Lys Pro Thr Ser Asp Lys Pro Gly Ser 
  1               5                  10                  15
Pro Tyr Arg Ser Val Thr His Phe Asp Ser Leu Ala Val Ile Asp Ile 
             20                  25                  30
Pro Gly Ala Asp Thr Leu Asp Lys Leu Phe Asp His Ala Val Ala Lys 
         35                  40                  45
Phe Gly Lys Lys Asp Ser Leu Gly Thr Arg Glu Ile Leu Ser Glu Glu 
     50                  55                  60
Asn Glu Met Gln Pro Asn Gly Lys Val Phe Lys Lys Leu Ile Leu Gly 
 65                  70                  75                  80
Asn Tyr Lys Trp Ile Asn Tyr Leu Glu Val Asn Cys Arg Val Asn Asn 
                 85                  90                  95
Phe Gly Ser Gly Leu Thr Ala Leu Gly Leu Lys Pro Lys Asn Thr Ile 
             100                105                110
Ala Ile Phe Cys Glu Thr Arg Ala Glu Trp Met Ile Ala Ala Gln Thr 
         115                120                125
Cys Phe Lys Tyr Asn Phe Pro Leu Val Thr Leu Tyr Ala Thr Leu Gly 
     130                135                140
Lys Glu Ala Val Val His Gly Leu Asn Glu Ser Glu Ala Ser Tyr Leu 
 145                150                155                160
Ile Thr Ser Val Glu Leu Leu Glu Ser Lys Leu Lys Ala Ala Leu Leu 
                 165                170                175
Asp Ile Asn Cys Val Lys His Ile Ile Tyr Val Asp Asn Lys Thr Ile 
             180                185                190
Asn Arg Ala Glu Tyr Pro Glu Gly Leu Glu Ile His Ser Met Gln Ser 
         195                200                205
Val Glu Glu Leu Gly Ser Lys Pro Glu Asn Ser Ser Ile Pro Pro Ser 
     210                215                220
Arg Pro Thr Pro Ser Asp Met Ala Ile Val Met Tyr Thr Ser Gly Ser 
 225                230                235                240
Thr Gly Arg Pro Lys Gly Val Met Met His His Ser Asn Leu Ile Ala 
                 245                250                255
Gly Met Thr Gly Gln Cys Glu Arg Ile Pro Gly Leu Gly Pro Lys Asp 
             260                265                270
Thr Tyr Ile Gly Tyr Leu Pro Leu Ala His Val Leu Glu Leu Thr Ala 
         275                280                285
Glu Ile Ser Cys Phe Thr Tyr Gly Cys Arg Ile Gly Tyr Ser Ser Pro 
     290                295                300
Leu Thr Leu Ser Asp Gln Ser Ser Lys Ile Lys Lys Gly Ser Lys Gly 
 305                310                315                320
Asp Cys Thr Val Leu Lys Pro Thr Leu Met Ala Ala Val Pro Glu Ile 
                 325                330                335
Met Asp Arg Ile Tyr Lys Asn Val Met Ser Lys Val Gln Glu Met Asn 
             340                345                350
Tyr Ile Gln Lys Thr Leu Phe Lys Ile Gly Tyr Asp Tyr Lys Leu Glu 
         355                360                365
Gln Ile Lys Lys Gly Tyr Asp Ala Pro Leu Cys Asn Leu Ile Leu Phe 
     370                375                380
Lys Lys Val Lys Ala Leu Leu Gly Gly Asn Val Arg Met Met Leu Ser 
 385                390                395                400
Gly Gly Ala Pro Leu Ser Pro Gln Thr His Arg Phe Met Asn Val Cys 
                 405                410                415
Phe Cys Cys Pro Ile Gly Gln Gly Tyr Gly Leu Thr Glu Ser Cys Gly 
             420                425                430
Ala Gly Thr Val Thr Glu Val Thr Asp Tyr Thr Thr Gly Arg Val Gly 
         435                440                445
Ala Pro Leu Ile Cys Cys Glu Ile Lys Leu Lys Asp Trp Gln Glu Gly 
     450                455                460
Gly Tyr Thr Val His Asp Lys Pro Asn Pro Arg Gly Glu Ile Val Ile 
 465                470                475                480
Gly Gly Gln Asn Ile Ser Met Gly Tyr Phe Lys Asn Glu Glu Lys Thr 
                 485                490                495
Ala Glu Asp Tyr Ser Val Asp Glu Asn Gly Gln Arg Trp Phe Cys Thr 
             500                505                510
Gly Asp Ile Gly Glu Phe His Pro Asp Gly Cys Leu Gln Ile Ile Asp 
         515                520                525
Arg Lys Lys Asp Leu Val Lys Leu Gln Ala Gly Glu Tyr Val Ser Leu 
     530                535                540
Gly Lys Val Glu Ala Ala Leu Lys Asn Cys Pro Leu Ile Asp Asn Ile 
 545                550                555                560
Cys Ala Phe Ala Lys Ser Asp Gln Ser Tyr Val Ile Ser Phe Val Val 
                 565                570                575
Pro Asn Gln Lys Lys Leu Thr Leu Leu Ala Gln Gln Lys Gly Val Glu 
             580                585                590
Gly Ser Trp Val Asp Ile Cys Asn Asn Pro Ala Met Glu Ala Glu Ile 
         595                600                605
Leu Lys Glu Ile Arg Glu Ala Ala Asn Ala Met Lys Leu Glu Arg Phe 
     610                615                620
Glu Ile Pro Ile Lys Val Arg Leu Ser Pro Glu Pro Trp Thr Pro Glu 
 625                630                635                640
Thr Gly Leu Val Thr Asp Ala Phe Lys Leu Lys Arg Lys Glu Leu Lys 
                 645                650                655
Asn His Tyr Leu Lys Asp Ile Glu Arg Met Tyr Gly Gly Lys 
             660                665                670



<210> 2228
<211> 5356
<212> DNA
<213> Homo sapiens
<308> NM_022977
<400> 2228

cgggattcg  ctggctctg  cacaccacc  cgcgccccc  ctccgcccg  ccctccggg  60
gcgtctttt  cgggctcgc  ctgagtccc  cctccgccg  ctgtccggg  gcgcgcgcg  120
cgctgcggc  ttttctctg  cctccgccg  gcgctcctc  tcgtcccag  gctagcggg  180
acgcggttc  tttttgcga  ctttccgag  gccaggcgc  ggccggctg  gaagacgcg  240
tgggccgcc  ctccgattg  aatcacaga  gatattcgt  ttcttctta  gagaaaaag  300
ggacatttt  gctttctca  ttgaaggcg  actttattg  cggcttcca  agattacta  360
cttttatct  tatcactaa  attgaactg  cttggctgt  ctgctattc  tactgctgc  420
tctattatt  ccttcttca  cacaataag  ctttcaaaa  ccaaagaat  acaagaaat  480
agcaccatt  tagaagcct  tccactatg  aacttaagc  aaatgtgct  accattatt  540
tgctgcctg  ccacttgtt  ataacaata  acagtgccc  tatatttat  ccatggtat  600
ttcttacca  tgccaagaa  aaaaacgct  tggcaaaga  aataaaagc  aagcccact  660
cagacaaac  tggaagtcc  tatcgctct  tcacacact  cgactcact  gctgtaata  720
acatccctg  agcagatac  ctggataaa  tatttgacc  tgctgtatc  aagtttggg  780
agaaggaca  ccttgggac  agggaaatc  taagtgaag  aaatgaaat  cagccaaat  840
gaaaagttt  taagaagtt  attcttggg  attataaat  gatgaacta  cttgaagtg  900
atcgcagag  gaataactt  ggtagtgga  tcactgcac  gggactaaa  ccaaagaac  960
ccattgcca  cttctgtga  accagggcc  aatggatga  tgcagcaca  acctgcttt  1020
agtacaact  tcctcttgt  actttatat  ccacacttg  caaagaagc  gtagttcat  1080
ggctaaatg  atctgaggc  tcctatctg  ttaccagtg  tgaacttct  gaaagtaaa  1140
ttaagactg  attgttaga  atcagttgt  ttaaacata  catttatgt  gacaataag  1200
ctatcaata  agcagagta  cctgaagga  ttgagattc  cagcatgca  tcagtagaa  1260
agttgggat  taacccaga  aacttgggc  ttcctccaa  tagaccaac  ccttcagac  1320
tggccattg  tatgtatac  agtggttct  ctggccgac  taagggagt  atgatgcat  1380
atagcaatt  gatagctgg  atgacaggc  agtgtgaaa  aatacctgg  ctgggaccg  1440
aggacacat  tattggcta  ttgcctttg  ctcatgtgc  agaactgac  gcagagata  1500
cttgcttta  ctatggctg  aggattgga  attcttctc  gcttacact  tctgaccag  1560
ccagcaaaa  taaaaaagg  agcaaagga  actgtactg  actgaagcc  acacttatg  1620
ctgctgttc  ggaaatcat  gatagaatt  ataagaatg  tatgagcaa  gtccaagag  1680
tgaattata  tcagaaaac  ctgttcaag  tagggtatg  ttacaaatt  gaacagatc  1740
aaaagggat  tgatgcacc  ctttgcaat  tgttactgt  taaaaaggt  aaggccctg  1800
tgggaggga  tgtccgcat  atgctgtct  gaggggccc  gctatctcc  cagacacac  1860
gattcatga  tgtctgctt  tgctgccca  ttggccagg  ttatggact  acagaatca  1920
gtggtgctg  gacagttac  gaagtaact  actatacta  tggcagagt  ggagcacct  1980
ttatttgct  tgaaattaa  ctaaaagac  ggcaagaag  cggttatac  attaatgac  2040
agccaaacc  cagaggtga  atcgtaatt  gtggacaga  catctccat  ggatatttt  2100
aaaatgaag  gaaaacagc  gaagattat  ctgtggatg  aaatggaca  aggtggttt  2160
gcactggtg  tattggaga  ttccatccc  atggatgtt  acagattat  gatcgtaag  2220
aagatctag  gaagttaca  gcaggagag  atgtatctc  tgggaaagt  gaagctgca  2280
tgaagaatt  tccacttat  gacaacatc  gtgcttttg  caaaagtga  cagtcctat  2340
tgatcagtt  tgtggttcc  aaccagaaa  ggttgacac  tttggcaca  cagaaaggg  2400
tagaaggaa  ttgggttga  atctgcaat  atcctgcta  ggaagctga  atactgaaa  2460
aaattcgag  agctgcaaa  gccatgaaa  tggagcgat  tgaaattcc  atcaaggtt  2520
gattaagcc  agagccatg  acccctgaa  ctggtttgg  aactgatgc  ttcaaactg  2580
aaaggaagg  gctgaggaa  cattacctc  aagacattg  acgaatgta  gggggcaaa  2640
aaaatgttg  tgtcttatt  acagttgtg  aggaggtag  ctggtggtt  tcaacctct  2700
gaattttaa  cctttgttg  actgttaga  tgtaaggta  atcattcta  agatagagt  2760
aaaagaaaa  aaaaccaaa  gttattaaa  ttgttgtcc  gtttacttt  acttagttt  2820
gcatagttc  agtgcagct  aaattgaaa  gttatttcc  tttagctgt  ttattatag  2880
gcagaaatt  tgtttttaa  aattagcct  agatatact  gtttttgta  agaaaaata  2940
ttaatgttg  acaaaataa  ttggagttg  agtagaatg  agtttgagg  aatttgcag  3000
ttccaatgc  tcttgtctt  ctatttcag  agtttaaat  ttaagcatg  cagaaaata  3060
gtattaaca  tactcaaag  aaaagtgct  cagggcttt  aaattctct  ccaaccatt  3120
atcttgaag  aaaaattca  tagtaatat  atacacaaa  tcaaataat  ccttagaag  3180
tattaagat  ataattgtt  cataggtta  atatagagt  attgtaatg  tgtgaataa  3240
tacagtgcc  aaaataaga  tagaacaac  tatacaaca  caaaaaata  ctagtaata  3300
atttaaagg  aaattgagc  gcttttttt  aaactttga  atctaaaaa  aactgtaat  3360
atttgaatg  ctaagagga  agtacattt  ttgaaatgc  gaaaattgc  tttctgtgt  3420
tattcaaac  gaaaagctg  gaccaagag  aaggaaggt  aaaagttaa  aggcaaaca  3480
tttctctta  aaaaggtga  aaaatcata  gtatttgga  ttagaaccc  tgcacagca  3540
tgaacctgg  aaagagatt  aaactctga  tttatcttt  ataacaggg  ttgatttta  3600
aatgtacat  tattaaatt  catttgtaa  ttaaggtct  tttgctgtt  ctgatttta  3660
tcttgatca  tagtttgca  ttcagaaag  ctttcattt  gctttaagt  tagcaaagc  3720
gggttataa  gaatgactt  cccaatatc  tgcttgaac  tacagtgat  aacttggat  3780
agttttggg  agttaaagg  aagaaaaca  tgttatcat  ttttcctgt  tgggaagag  3840
ttagaaact  gaaatacta  atttgggag  agggcagag  tacttgata  gggacttga  3900
gtttgtgca  taacttggg  gtgtggttt  tttttgaat  tttaattaa  acctgggat  3960
atatatccc  gataaatat  cacacttga  ccatagtta  tgtaaaatg  aaaaaatct  4020
aatactgtt  ttctttgca  tttttctta  tcatttttt  tatatatgc  tatatatat  4080
tgtgtgtgt  tgttgctta  gttgttttg  acagatgtg  gccaccatt  caacaaaat  4140
cattctttt  gctctaaaa  atttatgaa  aaaatactt  aatgttatg  atatggtgg  4200
aataaggga  aaatcaagt  ttataaaca  gaatgaagg  ttttgtaaa  atttctgtt  4260
agcgttttg  aaggtaaaa  tttaggcaa  ttttccctg  agttatgtg  atgtgagta  4320
tctcattct  cccaacttg  ctttgaaga  tgaaatacc  ttattatca  gtagactac  4380
gttcagctt  tattccttc  ctggttgtt  atcccttag  aatgagttt  ttagacttt  4440
ccaatatgt  atttttttt  ccatttaga  tggtgattt  aaatgtgtg  gtgcatgta  4500
tatcttatc  cagatattt  cacccccaa  ctgccccca  ctcccaaaa  ctagaacac  4560
gccaactga  ctgttatag  tcctttaga  acacataat  aacacttaa  gttgggtgc  4620
gctaattct  tgcaaaaat  caaatattg  taagggacc  gggagatgc  actacccct  4680
gattttcca  ctaaaaata  acatgttta  gtaaacaaa  ctttccata  ccatagtga  4740
ttttcaagt  tttaagcct  aagattttg  tctcacatt  ttatacctg  ttaaattgc  4800
cacagttat  acatacaca  cagccatca  ctaaagttg  actttaaaa  tttactaca  4860
tatgtacat  tctaagtca  acacttgtg  cttttgctt  aattccatg  atgttcctg  4920
ctccttgat  tttgtattt  ttctttttt  ctctagagt  gaggtataa  tgtgtgata  4980
ttcagaaat  cagataaat  attcaaaaa  tcacagtta  ggagaatca  gtttctttg  5040
tcatgaata  ctgattagt  agtcttgcc  atattttcc  gatagcata  gacaaatgt  5100
tctaaggta  caagatgag  acagataaa  attgtgtgg  gttttggat  tggagagaa  5160
tattttaat  tttaaatgc  gttacaaat  ataatgtat  catatttgt  ctttctgtt  5220
aaatgcatg  ttgcagaat  gtttagatt  tgtgtttat  cttgatgaa  agctttgtt  5280
gttcttgtt  ttaagtttg  actcaaatc  taagaaata  atccaccca  gttatcaaa  5340
aaaaaaaaa  aaaaaa  5356



<210> 2229
<211> 711
<212> PRT
<213> Homo sapiens
<308> O60488
<400> 2229

Met Lys Leu Lys Leu Asn Val Leu Thr Ile Ile Leu Leu Pro Val His 
  1               5                  10                  15
Leu Leu Ile Thr Ile Tyr Ser Ala Leu Ile Phe Ile Pro Trp Tyr Phe 
             20                  25                  30
Leu Thr Asn Ala Lys Lys Lys Asn Ala Met Ala Lys Arg Ile Lys Ala 
         35                  40                  45
Lys Pro Thr Ser Asp Lys Pro Gly Ser Pro Tyr Arg Ser Val Thr His 
     50                  55                  60
Phe Asp Ser Leu Ala Val Ile Asp Ile Pro Gly Ala Asp Thr Leu Asp 
 65                  70                  75                  80
Lys Leu Phe Asp His Ala Val Ser Lys Phe Gly Lys Lys Asp Ser Leu 
                 85                  90                  95
Gly Thr Arg Glu Ile Leu Ser Glu Glu Asn Glu Met Gln Pro Asn Gly 
             100                105                110
Lys Val Phe Lys Lys Leu Ile Leu Gly Asn Tyr Lys Trp Met Asn Tyr 
         115                120                125
Leu Glu Val Asn Arg Arg Val Asn Asn Phe Gly Ser Gly Leu Thr Ala 
     130                135                140
Leu Gly Leu Lys Pro Lys Asn Thr Ile Ala Ile Phe Cys Glu Thr Arg 
 145                150                155                160
Ala Glu Trp Met Ile Ala Ala Gln Thr Cys Phe Lys Tyr Asn Phe Pro 
                 165                170                175
Leu Val Thr Leu Tyr Ala Thr Leu Gly Lys Glu Ala Val Val His Gly 
             180                185                190
Leu Asn Glu Ser Glu Ala Ser Tyr Leu Ile Thr Ser Val Glu Leu Leu 
         195                200                205
Glu Ser Lys Leu Lys Thr Ala Leu Leu Asp Ile Ser Cys Val Lys His 
     210                215                220
Ile Ile Tyr Val Asp Asn Lys Ala Ile Asn Lys Ala Glu Tyr Pro Glu 
 225                230                235                240
Gly Phe Glu Ile His Ser Met Gln Ser Val Glu Glu Leu Gly Ser Asn 
                 245                250                255
Pro Glu Asn Leu Gly Ile Pro Pro Ser Arg Pro Thr Pro Ser Asp Met 
             260                265                270
Ala Ile Val Met Tyr Thr Ser Gly Ser Thr Gly Arg Pro Lys Gly Val 
         275                280                285
Met Met His His Ser Asn Leu Ile Ala Gly Met Thr Gly Gln Cys Glu 
     290                295                300
Arg Ile Pro Gly Leu Gly Pro Lys Asp Thr Tyr Ile Gly Tyr Leu Pro 
 305                310                315                320
Leu Ala His Val Leu Glu Leu Thr Ala Glu Ile Ser Cys Phe Thr Tyr 
                 325                330                335
Gly Cys Arg Ile Gly Tyr Ser Ser Pro Leu Thr Leu Ser Asp Gln Ser 
             340                345                350
Ser Lys Ile Lys Lys Gly Ser Lys Gly Asp Cys Thr Val Leu Lys Pro 
         355                360                365
Thr Leu Met Ala Ala Val Pro Glu Ile Met Asp Arg Ile Tyr Lys Asn 
     370                375                380
Val Met Ser Lys Val Gln Glu Met Asn Tyr Ile Gln Lys Thr Leu Phe 
 385                390                395                400
Lys Ile Gly Tyr Asp Tyr Lys Leu Glu Gln Ile Lys Lys Gly Tyr Asp 
                 405                410                415
Ala Pro Leu Cys Asn Leu Leu Leu Phe Lys Lys Val Lys Ala Leu Leu 
             420                425                430
Gly Gly Asn Val Arg Met Met Leu Ser Gly Gly Ala Pro Leu Ser Pro 
         435                440                445
Gln Thr His Arg Phe Met Asn Val Cys Phe Cys Cys Pro Ile Gly Gln 
     450                455                460
Gly Tyr Gly Leu Thr Glu Ser Cys Gly Ala Gly Thr Val Thr Glu Val 
 465                470                475                480
Thr Asp Tyr Thr Thr Gly Arg Val Gly Ala Pro Leu Ile Cys Cys Glu 
                 485                490                495
Ile Lys Leu Lys Asp Trp Gln Glu Gly Gly Tyr Thr Ile Asn Asp Lys 
             500                505                510
Pro Asn Pro Arg Gly Glu Ile Val Ile Gly Gly Gln Asn Ile Ser Met 
         515                520                525
Gly Tyr Phe Lys Asn Glu Glu Lys Thr Ala Glu Asp Tyr Ser Val Asp 
     530                535                540
Glu Asn Gly Gln Arg Trp Phe Cys Thr Gly Asp Ile Gly Glu Phe His 
 545                550                555                560
Pro Asp Gly Cys Leu Gln Ile Ile Asp Arg Lys Lys Asp Leu Val Lys 
                 565                570                575
Leu Gln Ala Gly Glu Tyr Val Ser Leu Gly Lys Val Glu Ala Ala Leu 
             580                585                590
Lys Asn Cys Pro Leu Ile Asp Asn Ile Cys Ala Phe Ala Lys Ser Asp 
         595                600                605
Gln Ser Tyr Val Ile Ser Phe Val Val Pro Asn Gln Lys Arg Leu Thr 
     610                615                620
Leu Leu Ala Gln Gln Lys Gly Val Glu Gly Thr Trp Val Asp Ile Cys 
 625                630                635                640
Asn Asn Pro Ala Met Glu Ala Glu Ile Leu Lys Glu Ile Arg Glu Ala 
                 645                650                655
Ala Asn Ala Met Lys Leu Glu Arg Phe Glu Ile Pro Ile Lys Val Arg 
             660                665                670
Leu Ser Pro Glu Pro Trp Thr Pro Glu Thr Gly Leu Val Thr Asp Ala 
         675                680                685
Phe Lys Leu Lys Arg Lys Glu Leu Arg Asn His Tyr Leu Lys Asp Ile 
     690                695                700
Glu Arg Met Tyr Gly Gly Lys 
 705                710



<210> 2230
<211> 1899
<212> DNA
<213> Rattus norvegicus
<308> D86297
<400> 2230

gactttggg  tcaggatgg  ggcagcagc  atgttgcta  ggtcctgtc  agtgctctc  60
aagggcccc  caggcctcc  aggcaaagt  gctaaaact  accagttcc  atttggtat  120
ggacgctgc  ccatcctgg  cactcaagg  ccaacctgt  ctcaaatcc  tcttaaggc  180
accaaggct  gagcagact  tccgtcttg  actaagagc  attgtcctt  catgctgtc  240
gaactccaa  acaggaaga  caagattgt  cagagggca  ctccagaag  ccaagagga  300
gtcaagact  tcaagacag  cctgctgag  ttcatggag  caactaccc  aagccaatc  360
gtgcctcgt  tccaggatc  agagcagac  ggaggggca  ctcccctgc  gattcagaa  420
aatatgact  gaagccagg  ttttggtta  gaccaattt  ttagagaca  gatcatgga  480
aagaagcag  accacacat  ccgtgtgtt  aagactgtg  atcgctggg  taatgccta  540
ccctttgcc  aacacttct  cgaggcatc  atggactca  aggatgttt  tgtctggtg  600
agtaatgac  atttgggca  aagcaggca  cctcgtgtc  tgcaggcca  agaggagac  660
ctgaagaat  atggagctg  agctggggg  actcgcaat  tctcaggta  aagcaagtt  720
catgtggag  ttgaacagg  gctggctga  ctacatcat  aggactcgg  tctgctctt  780
tcctcctgt  ttgtggcca  tgattctac  ctctttaca  tggccaagc  tctgccagg  840
tgtgagatc  actcagacg  aggcaatca  gcctccatg  tccaaggca  tcgtaacag  900
ggtgcagtc  agtttgtct  cagacacaa  gacccaggc  acctgaaga  acttcttga  960
aagtccgat  ccaagacac  aaaaattgt  gcttttgag  ctgttcact  catggatgg  1020
gccatctgt  ctctggagg  attgtgtga  gtggcccac  agtacgggg  cctgacctt  1080
gtggatgaa  tccatgccg  aggactata  ggaacccgg  gtgcaggga  cggggagcg  1140
gatggaatt  tgcacaagc  tgacatcat  tctggaact  ttggcaagg  ctttggctg  1200
gtcggtggc  atatcgcca  cactcggga  ttggtggac  tggtgcgct  ctacgctgc  1260
ggcttcatc  ttaccactt  actgcctcc  atggtgctc  ctggagctc  agagtctgt  1320
cgtctactc  agggagagg  gggtcaagc  ctgaggcgt  cacaccagc  caacgtcaa  1380
catatgcgc  agctactaa  ggacagggg  tttcctgtt  tcccctgtc  cagccacat  1440
atccccata  gggtgggta  tgcggcact  aacagcaag  tctgtgatc  tctgctcgc  1500
aagcacagc  tctatgtgc  ggccatcaa  tacccaact  tgcctcgtg  tgaggagct  1560
ctgcgcttg  ccccctccc  ccaccacag  cctcagatg  tggaaaact  tgtggagaa  1620
ttgctgctg  cctggactg  ggtggggtt  cccctccaa  atgtgtctg  ggctgcatg  1680
aacttctgc  gtcgtcctg  gcactttga  cttatgagc  agtgggagc  atcctactt  1740
gggaacatg  gaccccaat  tgttactac  tatgcctaa  gagccagct  ccttagatg  1800
caaccccac  tgcactccc  ctggggatg  tcttcctcc  actctctgc  ttgctgtgt  1860
cttctagct  acttgattc  aaaaataaa  agcaacctg  1899



<210> 2231
<211> 587
<212> PRT
<213> Rattus norvegicus
<308> Q63147
<400> 2231

Met Val Ala Ala Ala Met Leu Leu Arg Ser Cys Pro Val Leu Ser Lys 
  1               5                  10                  15
Gly Pro Thr Gly Leu Leu Gly Lys Val Ala Lys Thr Tyr Gln Phe Leu 
             20                  25                  30
Phe Gly Ile Gly Arg Cys Pro Ile Leu Ala Thr Gln Gly Pro Thr Cys 
         35                  40                  45
Ser Gln Ile His Leu Lys Ala Thr Lys Ala Gly Ala Asp Ser Pro Ser 
     50                  55                  60
Trp Thr Lys Ser His Cys Pro Phe Met Leu Ser Glu Leu Gln Asp Arg 
 65                  70                  75                  80
Lys Ser Lys Ile Val Gln Arg Ala Ala Pro Glu Val Gln Glu Asp Val 
                 85                  90                  95
Lys Thr Phe Lys Thr Asp Leu Leu Ser Phe Met Glu Ser Thr Thr Arg 
             100                105                110
Ser Gln Ser Val Pro Arg Phe Gln Asp Pro Glu Gln Thr Gly Gly Ala 
         115                120                125
Pro Pro Leu Leu Ile Gln Asn Asn Met Thr Gly Ser Gln Ala Phe Gly 
     130                135                140
Tyr Asp Gln Phe Phe Arg Asp Lys Ile Met Glu Lys Lys Gln Asp His 
 145                150                155                160
Thr Tyr Arg Val Phe Lys Thr Val Asn Arg Trp Ala Asn Ala Tyr Pro 
                 165                170                175
Phe Ala Gln His Phe Ser Glu Ala Ser Met Asp Ser Lys Asp Val Ser 
             180                185                190
Val Trp Cys Ser Asn Asp Tyr Leu Gly Ile Ser Arg His Pro Arg Val 
         195                200                205
Leu Gln Ala Ile Glu Glu Thr Leu Lys Asn His Gly Ala Gly Ala Gly 
     210                215                220
Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys Phe His Val Glu Leu Glu 
 225                230                235                240
Gln Glu Leu Ala Glu Leu His His Lys Asp Ser Ala Leu Leu Phe Ser 
                 245                250                255
Ser Cys Phe Val Ala Asn Asp Ser Thr Leu Phe Thr Leu Ala Lys Leu 
             260                265                270
Leu Pro Gly Cys Glu Ile Tyr Ser Asp Ala Gly Asn His Ala Ser Met 
         275                280                285
Ile Gln Gly Ile Arg Asn Ser Gly Ala Val Lys Phe Val Phe Arg His 
     290                295                300
Asn Asp Pro Gly His Leu Lys Lys Leu Leu Glu Lys Ser Asp Pro Lys 
 305                310                315                320
Thr Pro Lys Ile Val Ala Phe Glu Thr Val His Ser Met Asp Gly Ala 
                 325                330                335
Ile Cys Pro Leu Glu Glu Leu Cys Asp Val Ala His Gln Tyr Gly Ala 
             340                345                350
Leu Thr Phe Val Asp Glu Val His Ala Val Gly Leu Tyr Gly Thr Arg 
         355                360                365
Gly Ala Gly Ile Gly Glu Arg Asp Gly Ile Met His Lys Leu Asp Ile 
     370                375                380
Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly Cys Val Gly Gly Tyr Ile 
 385                390                395                400
Ala Ser Thr Arg Asp Leu Val Asp Met Val Arg Ser Tyr Ala Ala Gly 
                 405                410                415
Phe Ile Phe Thr Thr Ser Leu Pro Pro Met Val Leu Ser Gly Ala Leu 
             420                425                430
Glu Ser Val Arg Leu Leu Lys Gly Glu Glu Gly Gln Ala Leu Arg Arg 
         435                440                445
Ala His Gln Arg Asn Val Lys His Met Arg Gln Leu Leu Met Asp Arg 
     450                455                460
Gly Phe Pro Val Ile Pro Cys Pro Ser His Ile Ile Pro Ile Arg Val 
 465                470                475                480
Gly Asn Ala Ala Leu Asn Ser Lys Ile Cys Asp Leu Leu Leu Ala Lys 
                 485                490                495
His Ser Ile Tyr Val Gln Ala Ile Asn Tyr Pro Thr Val Pro Arg Gly 
             500                505                510
Glu Glu Leu Leu Arg Leu Ala Pro Ser Pro His His Ser Pro Gln Met 
         515                520                525
Met Glu Asn Phe Val Glu Lys Leu Leu Leu Ala Trp Thr Glu Val Gly 
     530                535                540
Leu Pro Leu Gln Asp Val Ser Val Ala Ala Cys Asn Phe Cys Arg Arg 
 545                550                555                560
Pro Val His Phe Glu Leu Met Ser Glu Trp Glu Arg Ser Tyr Phe Gly 
                 565                570                575
Asn Met Gly Pro Gln Tyr Val Thr Thr Tyr Ala 
             580                585



<210> 2232
<211> 2149
<212> DNA
<213> Homo sapiens
<308> NM_001695
<400> 2232

gttctgtgt  cgcttgggt  gaggaagcc  tgaggccgg  gcttaggtc  ggaagggat  60
gatcgctga  ccgatagcg  ccgctaggc  gtctgcctc  gtacctgtt  ctgctgcta  120
ttcctcgtt  gacaccttc  tggaatctc  cttgatttt  gaggaaata  ctagtaaca  180
acatgactg  gttctggct  atatctgct  ctggggaga  aacctgtca  caaacatgg  240
agaaattgc  tgcggcaac  tcaaagaac  ataatcttg  tgtcacttc  aagttcaat  300
ttcctgact  aaaggttgg  acgttggat  tcttggttg  cttgtcaga  gaactggct  360
aactggatg  atttgtaga  ggagtggtt  agaaagtag  tcaatacat  gctgatgta  420
tggaagata  caaagacaa  gttcaagag  atctgttgg  taatggagt  gacttggtt  480
cttatataa  aaggttcca  tgggacatg  ccaaatatc  aatcaagca  tccctgaaa  540
atatttctg  aataattgc  aagggagta  ctcagattg  taatgacct  aaatctcga  600
catctgcat  caataacct  aaaggaaat  ttcagaatt  ggaacgaaa  aatgcagga  660
gtttgctaa  tagaagtct  gcagaaatt  tgaagaagg  tgactttgt  cttgattca  720
agtatctcg  cacattact  gtagtagtt  ccaagttaa  ccacaacga  tggattaag  780
agtatgaaa  actagccga  atggtagtt  caaggtcta  caatgttct  tcagaggac  840
aagacagtt  cctgtgtaa  gtcaccttg  ttaggaagg  agttgatga  ttcagacac  900
aagccagag  aaacaaatt  attgttcgt  acttccagt  taatgaaga  gagatgaaa  960
cagataaag  agaaatgaa  aggctttct  ctgataaga  aaaacaatt  ggaccactt  1020
tacggtggc  gaaagtgaa  tttagtgaa  catttattg  atggattca  gtgaaagca  1080
tacgggttt  cgttgagtc  gttttaagg  atggcttgc  agtgaactt  caagcaatg  1140
tacttcagc  caataagaa  actttgaag  aactgagag  agtattaca  gaattgtat  1200
aacatctag  cagcagtgc  gcagctatt  ttgatgctc  tatggatat  ccaggttta  1260
acctgagtc  acaagaata  tacccctat  tgtactaca  gattgattg  aacttgctg  1320
aattcaagt  aaaatgggc  cctcccccg  caatcctgt  cttgtgttt  tgtgtgcta  1380
cagaaataa  ttgcagtat  gtcgtactt  taactctag  atcctttgc  tgcttctta  1440
cccctttcc  aggtgaatt  tcccacagt  gtctgtatc  caacatttt  tttttaaag  1500
aaaaaatat  tatatatag  ttcttttta  tgatcaggt  tgtaaatgt  tactaaaaa  1560
atcagagtt  atttataaa  agaatagtt  atttaaaga  aaggtctct  ccttattga  1620
atcatggta  gcattaatt  catttgtta  tattgtgca  aaaagccct  ttcacaggg  1680
aatggtgta  acatttata  tgttttgtt  actgtattt  gtagacata  ctgttgaat  1740
gttactgaa  catgatgta  agaatatgt  accatcttc  ggtatggga  ttctgaacg  1800
ttcaaattt  aatcaatga  cactgtcaa  acccacagg  gagaataaa  ttacctgtg  1860
aaaggtgta  tgtggtgtg  gtaacttaa  attacagtt  tgtttgaga  ttaaatgat  1920
tcatagctc  cttgctatg  tgcttccag  attttgtta  atgctgagg  gtaaccatt  1980
gtgttgtct  actttcgta  gatttaatt  agccaaatt  gggtcagaa  acaaatttg  2040
agatgactt  tcagtatat  atgggtatt  acatttgaa  actagaatt  taggtctct  2100
aaataatta  gaatagagc  agttttgaa  aaagtctag  agaactatg  2149



<210> 2233
<211> 382
<212> PRT
<213> Homo sapiens
<308> P21283
<400> 2233

Met Thr Glu Phe Trp Leu Ile Ser Ala Pro Gly Glu Lys Thr Cys Gln 
  1               5                  10                  15
Gln Thr Trp Glu Lys Leu His Ala Ala Thr Ser Lys Asn Asn Asn Leu 
             20                  25                  30
Ala Val Thr Ser Lys Phe Asn Ile Pro Asp Leu Lys Val Gly Thr Leu 
         35                  40                  45
Asp Val Leu Val Gly Leu Ser Asp Glu Leu Ala Lys Leu Asp Ala Phe 
     50                  55                  60
Val Glu Gly Val Val Lys Lys Val Ala Gln Tyr Met Ala Asp Val Leu 
 65                  70                  75                  80
Glu Asp Ser Lys Asp Lys Val Gln Glu Asn Leu Leu Ala Asn Gly Val 
                 85                  90                  95
Asp Leu Val Thr Tyr Ile Thr Arg Phe Gln Trp Asp Met Ala Lys Tyr 
             100                105                110
Pro Ile Lys Gln Ser Leu Lys Asn Ile Ser Glu Ile Ile Ala Lys Gly 
         115                120                125
Val Thr Gln Ile Asp Asn Asp Leu Lys Ser Arg Ala Ser Ala Tyr Asn 
     130                135                140
Asn Leu Lys Gly Asn Leu Gln Asn Leu Glu Arg Lys Asn Ala Gly Ser 
 145                150                155                160
Leu Leu Thr Arg Ser Leu Ala Glu Ile Val Lys Lys Asp Asp Phe Val 
                 165                170                175
Leu Asp Ser Glu Tyr Leu Val Thr Leu Leu Val Val Val Pro Lys Leu 
             180                185                190
Asn His Asn Asp Trp Ile Lys Gln Tyr Glu Thr Leu Ala Glu Met Val 
         195                200                205
Val Pro Arg Ser Ser Asn Val Leu Ser Glu Asp Gln Asp Ser Tyr Leu 
     210                215                220
Cys Asn Val Thr Leu Phe Arg Lys Ala Val Asp Asp Phe Arg His Lys 
 225                230                235                240
Ala Arg Glu Asn Lys Phe Ile Val Arg Asp Phe Gln Tyr Asn Glu Glu 
                 245                250                255
Glu Met Lys Ala Asp Lys Glu Glu Met Asn Arg Leu Ser Thr Asp Lys 
             260                265                270
Lys Lys Gln Phe Gly Pro Leu Val Arg Trp Leu Lys Val Asn Phe Ser 
         275                280                285
Glu Ala Phe Ile Ala Trp Ile His Val Lys Ala Leu Arg Val Phe Val 
     290                295                300
Glu Ser Val Leu Arg Tyr Gly Leu Pro Val Asn Phe Gln Ala Met Leu 
 305                310                315                320
Leu Gln Pro Asn Lys Lys Thr Leu Lys Lys Leu Arg Glu Val Leu His 
                 325                330                335
Glu Leu Tyr Lys His Leu Asp Ser Ser Ala Ala Ala Ile Ile Asp Ala 
             340                345                350
Pro Met Asp Ile Pro Gly Leu Asn Leu Ser Gln Gln Glu Tyr Tyr Pro 
         355                360                365
Tyr Val Tyr Tyr Lys Ile Asp Cys Asn Leu Leu Glu Phe Lys 
     370                375                380



<210> 2234
<211> 1750
<212> DNA
<213> Rattus norvegicus
<308> D86373
<400> 2234

gcgaaggga  accctaacg  agcgaccct  ccgcggccg  ccagcctac  gcctagacc  60
ctgcagctg  cctcgggtc  caggaagct  catggtggg  gaagaaacg  ctctgagaa  120
ccggctgtc  agatctgct  agaatcctg  gcaagatga  gcccagaaa  atctcttgg  180
cacacacag  aatggtcac  ttaccatga  acagttgat  gccaagaag  ggcagttgg  240
ggcagaggc  gaggagctg  agccactgt  tctgaagga  gttgggtgt  actttgatg  300
ctttgtgac  aatctcatt  acaagtctg  atctctgga  aatggcggg  gtgcgctca  360
gaccttctc  attcttgaa  aaatgaaaa  caaccacag  gccaaagat  tgagagcac  420
tccagaaca  gggaagata  ttatttcaa  gcggtctct  ttagacgag  tgtttgaag  480
ggaccacat  agaacaatt  accacatgt  cattgccct  ctcatcatc  tcatcctta  540
cacgctcgt  gtggattac  tcgatgaag  aaggctggt  cttgagttc  gtctcctgg  600
ttatgcttt  ggccaattt  ctattgtta  ttggacatg  tgggccatg  tcctgtcta  660
actggcaat  ccctatttc  tgttccagc  ttgggccca  ggttacagc  agagttccc  720
cccactcat  tattccctt  tccatggcg  attcttctt  gtctttcaa  ttggaatcc  780
cggttttat  ccaacatat  ttgtcttag  atacacgct  cccccagcc  cccggttca  840
tctgatact  gagcagatt  gtttggtaa  gaaggctca  tcatatgtc  gagagaatg  900
gccacgagt  ctaagtgca  ccaaggaga  atcgagcac  gttccagta  ccacagtca  960
ccagtacct  tacttcctg  ttgctccta  acttattta  cgagacagc  accccagga  1020
tcctactgt  agatggggt  atgttgcta  gcagttttt  caggttttt  gttgcctgt  1080
ttatgtgta  tacatcttt  agagactct  tgcccctct  ttccggaat  tcaaacagg  1140
gccctttag  gctcgtgtc  tggtcctgt  tgtatttaa  tccatcttg  caggtgtgc  1200
gatgctgtt  ctttcgttc  ttgcctttt  gcactgctg  ctcaatgcc  ttgctgaaa  1260
gttacgctt  ggtgacagg  tgttttata  ggactggtg  aactctaca  cgtactcca  1320
ctactacag  acctggaat  tggtggtcc  cgactggct  tactactat  tttacaagg  1380
cctcctctg  tttttctcg  agaggttca  gcctgccgc  atgttggcc  tgttcgccc  1440
gtcagcagt  gtgcacgag  acgccctcg  tgtctgcct  agctacttc  acccagtgc  1500
cttcgtgct  ttcatgttc  ttggaatgg  ttttaactt  atcgttaac  acagtcgga  1560
aaggccagt  tggaacatc  tggttcggg  ttccctctt  ctcggccat  gagtcattc  1620
gtgctttta  tctcaagag  ggtatgctc  acagcgctg  cctctgaag  accctacat  1680
tctggatta  gtccggcca  ggacctgga  ttgtcgtta  gtgttttag  agccctggc  1740
ctgcctcctt  1750



<210> 2235
<211> 545
<212> PRT
<213> Rattus norvegicus
<308> O70536
<400> 2235

Met Val Gly Glu Glu Thr Ser Leu Arg Asn Arg Leu Ser Arg Ser Ala 
  1               5                  10                  15
Glu Asn Pro Glu Gln Asp Glu Ala Gln Lys Asn Leu Leu Asp Thr His 
             20                  25                  30
Arg Asn Gly His Ile Thr Met Lys Gln Leu Ile Ala Lys Lys Arg Gln 
         35                  40                  45
Leu Ala Ala Glu Ala Glu Glu Leu Lys Pro Leu Phe Leu Lys Glu Val 
     50                  55                  60
Gly Cys His Phe Asp Asp Phe Val Thr Asn Leu Ile Asp Lys Ser Ala 
 65                  70                  75                  80
Ser Leu Asp Asn Gly Gly Cys Ala Leu Thr Thr Phe Ser Ile Leu Glu 
                 85                  90                  95
Glu Met Lys Asn Asn His Arg Ala Lys Asp Leu Arg Ala Pro Pro Glu 
             100                105                110
Gln Gly Lys Ile Phe Ile Ser Arg Arg Ser Leu Leu Asp Glu Leu Phe 
         115                120                125
Glu Val Asp His Ile Arg Thr Ile Tyr His Met Phe Ile Ala Leu Leu 
     130                135                140
Ile Ile Phe Ile Leu Ser Thr Leu Val Val Asp Tyr Ile Asp Glu Gly 
 145                150                155                160
Arg Leu Val Leu Glu Phe Ser Leu Leu Ala Tyr Ala Phe Gly Gln Phe 
                 165                170                175
Pro Ile Val Ile Trp Thr Trp Trp Ala Met Phe Leu Ser Thr Leu Ala 
             180                185                190
Ile Pro Tyr Phe Leu Phe Gln Arg Trp Ala His Gly Tyr Ser Lys Ser 
         195                200                205
Ser His Pro Leu Ile Tyr Ser Leu Ile His Gly Ala Phe Phe Leu Val 
     210                215                220
Phe Gln Leu Gly Ile Leu Gly Phe Ile Pro Thr Tyr Val Val Leu Ala 
 225                230                235                240
Tyr Thr Leu Pro Pro Ala Ser Arg Phe Ile Leu Ile Leu Glu Gln Ile 
                 245                250                255
Arg Leu Val Met Lys Ala His Ser Tyr Val Arg Glu Asn Val Pro Arg 
             260                265                270
Val Leu Ser Ala Ala Lys Glu Lys Ser Ser Thr Val Pro Val Pro Thr 
         275                280                285
Val Asn Gln Tyr Leu Tyr Phe Leu Phe Ala Pro Thr Leu Ile Tyr Arg 
     290                295                300
Asp Ser Tyr Pro Arg Thr Pro Thr Val Arg Trp Gly Tyr Val Ala Met 
 305                310                315                320
Gln Phe Leu Gln Val Phe Gly Cys Leu Phe Tyr Val Tyr Tyr Ile Phe 
                 325                330                335
Glu Arg Leu Cys Ala Pro Leu Phe Arg Asn Ile Lys Gln Glu Pro Phe 
             340                345                350
Ser Ala Arg Val Leu Val Leu Cys Val Phe Asn Ser Ile Leu Pro Gly 
         355                360                365
Val Leu Met Leu Phe Leu Ser Phe Phe Ala Phe Leu His Cys Trp Leu 
     370                375                380
Asn Ala Phe Ala Glu Met Leu Arg Phe Gly Asp Arg Met Phe Tyr Lys 
 385                390                395                400
Asp Trp Trp Asn Ser Thr Ser Tyr Ser Asn Tyr Tyr Arg Thr Trp Asn 
                 405                410                415
Val Val Val His Asp Trp Leu Tyr Tyr Tyr Val Tyr Lys Asp Leu Leu 
             420                425                430
Trp Phe Phe Ser Lys Arg Phe Arg Pro Ala Ala Met Leu Ala Val Phe 
         435                440                445
Ala Leu Ser Ala Val Val His Glu Tyr Ala Leu Ala Val Cys Leu Ser 
     450                455                460
Tyr Phe Tyr Pro Val Leu Phe Val Leu Phe Met Phe Phe Gly Met Ala 
 465                470                475                480
Phe Asn Phe Ile Val Asn Asp Ser Arg Lys Arg Pro Val Trp Asn Ile 
                 485                490                495
Met Val Arg Ala Ser Leu Phe Leu Gly His Gly Val Ile Leu Cys Phe 
             500                505                510
Tyr Ser Gln Glu Trp Tyr Ala Arg Gln Arg Cys Pro Leu Lys Asn Pro 
         515                520                525
Thr Phe Leu Asp Tyr Val Arg Pro Arg Thr Trp Thr Cys Arg Tyr Val 
     530                535                540
Phe 
 545



<210> 2236
<211> 1013
<212> DNA
<213> Rattus norvegicus
<308> D86557
<400> 2236

ggagcaggc  cgctggcca  gatcacaga  tggagcacc  ttcttgtga  cccctggct  60
cccaggcag  ttcaactct  gaggacatg  ggcgaaagg  ggaggagga  tgtagctcc  120
ggaagaaac  gaccaccaa  atcaggaaa  ccttcatct  catggaagt  ctcggatca  180
gagcgttct  agaggtgtt  ctggtgaag  aaagagtga  tgggaaact  tttgctctg  240
agtgcatca  gaagtcacc  gccttccgg  acagtagcc  agagaatga  attgctgtg  300
tgaaaagga  caagcatga  aacattgtg  ccctggagg  tatctatga  agcaccacc  360
actactacc  ggtcatgca  cttgtttct  gaggtgagc  ttttgaccg  atcctagag  420
gtggtgtct  cacagaaaa  gatgccagt  tggtcatcc  gcaggtctt  tctgccgtg  480
aataccttc  tgagaatgg  atcgttcac  gagatctaa  gcctgaaaa  ctgctgtac  540
tcacccctg  ggagaactc  aagataatg  tcactgatt  tggcctatc  aagatggag  600
agaatggag  catgtccac  gcttgtggg  ccccaggct  tgtggctcc  gaagtgctg  660
cccagaagc  ctacagtaa  gctgtggac  gctggtcca  tggtgtcat  acatacata  720
tgctgtgtg  gtatccccc  ttctatgaa  aaacagaat  aaagctttt  gagaagatc  780
aagagggtt  ctacgagtt  gagtctcca  tctgggatg  catttctga  tcagccaag  840
actttattt  ccatctgct  gagaaggac  caaatgaac  atacacctg  gagaaagcc  900
tcagacacc  ttggattga  gggaacaca  ccctgcacc  ggacatcta  ccatctgtc  960
gcctccaga  tcagaagaa  tttgccaag  gcaagtgga  gcaagcctt  aat  1013



<210> 2237
<211> 309
<212> PRT
<213> Rattus norvegicus
<308> BAA19880
<400> 2237

Met Gly Arg Lys Glu Glu Glu Asp Cys Ser Ser Trp Lys Lys Gln Thr 
  1               5                  10                  15
Thr Asn Ile Arg Lys Thr Phe Ile Phe Met Glu Val Leu Gly Ser Gly 
             20                  25                  30
Ala Phe Ser Glu Val Phe Leu Val Lys Gln Arg Val Thr Gly Lys Leu 
         35                  40                  45
Phe Ala Leu Lys Cys Ile Lys Lys Ser Pro Ala Phe Arg Asp Ser Ser 
     50                  55                  60
Leu Glu Asn Glu Ile Ala Val Leu Lys Arg Ile Lys His Glu Asn Ile 
 65                  70                  75                  80
Val Thr Leu Glu Asp Ile Tyr Glu Ser Thr Thr His Tyr Tyr Leu Val 
                 85                  90                  95
Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Leu Glu Arg 
             100                105                110
Gly Val Tyr Thr Glu Lys Asp Ala Ser Leu Val Ile Gln Gln Val Leu 
         115                120                125
Ser Ala Val Lys Tyr Leu His Glu Asn Gly Ile Val His Arg Asp Leu 
     130                135                140
Lys Pro Glu Asn Leu Leu Tyr Leu Thr Pro Glu Glu Asn Ser Lys Ile 
 145                150                155                160
Met Ile Thr Asp Phe Gly Leu Ser Lys Met Glu Gln Asn Gly Val Met 
                 165                170                175
Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val Leu Ala 
             180                185                190
Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly Val Ile 
         195                200                205
Thr Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Glu Glu Thr Glu 
     210                215                220
Ser Lys Leu Phe Glu Lys Ile Lys Glu Gly Tyr Tyr Glu Phe Glu Ser 
 225                230                235                240
Pro Phe Trp Asp Asp Ile Ser Glu Ser Ala Lys Asp Phe Ile Cys His 
                 245                250                255
Leu Leu Glu Lys Asp Pro Asn Glu Arg Tyr Thr Cys Glu Lys Ala Leu 
             260                265                270
Arg His Pro Trp Ile Asp Gly Asn Thr Ala Leu His Arg Asp Ile Tyr 
         275                280                285
Pro Ser Val Ser Leu Gln Ile Gln Lys Asn Phe Ala Lys Ser Lys Trp 
     290                295                300
Arg Gln Ala Phe Asn 
 305



<210> 2238
<211> 1750
<212> DNA
<213> Homo sapiens
<308> NM_020439
<400> 2238

catcctcag  agcttcaac  ctggaggca  tgggtcgaa  ggaagaaga  gactgcagt  60
cctggaaga  acagaccac  aacatccgg  aaaccttca  ttttatgga  gtgctggga  120
caggagctt  ctcagaagt  ttcctggtg  agcaaagac  gactgggaa  ctctttgct  180
tgaagtgca  caagaagtc  cctgccttc  gggacagca  cctggagaa  gagattgct  240
tgttgaaaa  gatcaagca  gaaaacatt  tgaccctgg  ggacatcta  gagagcacc  300
cccactact  cctggtcat  cagcttgtt  ctggtgggg  gctctttga  cggatcctg  360
agcggggtg  ctacacaga  aaggatgcc  gtctggtga  ccagcaggt  ttgtcggca  420
tgaaatacc  acatgagaa  ggcatcgtc  acagagact  aaagcccga  aacctgctt  480
accttaccc  tgaagagaa  tctaagatc  tgatcactg  ctttggtct  tccaagatg  540
aacagaatg  catcatgtc  actgcctgt  ggaccccag  ctacgtggc  ccagaagtg  600
tggcccaga  accctacag  aaggctgtg  attgctggt  catcggcgt  atcacctac  660
tattgctct  tggataccc  ccattctat  aagaaacgg  gtctaagct  ttcgagaag  720
tcaaggagg  ctactatga  tttgagtct  cattctggg  tgacatttc  gagtcagcc  780
aggacttta  ttgccactt  cttgagaag  atccgaacg  gcggtacac  tgtgagaag  840
ccttgagtc  tccctggat  gacggaaac  cagccctcc  ccgggacat  tacccatca  900
tcagcctcc  gatccagaa  aactttgct  agagcaagt  gaggcaagc  ttcaacgca  960
cagctgtgg  gcaccacat  aggaagcta  acatgaacc  gcacagccc  ggcgtccgc  1020
cagaggtgg  gaacaggcc  cctgaaact  aagcctcag  aacctctag  cccagctcc  1080
ctgagatca  catcaccga  gcacctgtc  tggaccaca  tgtagcact  cctgccctg  1140
cccaattac  ctgccagca  ggccgccgg  ccactgccc  tggtggcag  tccctcaac  1200
gcctggtca  tggctccct  cacatcagc  gcagcctgg  gcccatgca  caggggtcc  1260
tggccgccg  gccctgtgg  tgctgctcc  gctgcctga  cattgggag  aaaggaaag  1320
cctcctact  ctctgagcc  acactcctc  aaaaggcca  caaaaaaca  aacttcaag  1380
cggaggtca  ggtaccagt  aaagccagt  gcagctccc  ctgccgggc  gggcagact  1440
gagtctgtc  cattatgtg  ttcctggag  ctgtgccta  gtcactgca  ttttcagga  1500
acatattca  ctcctctgc  cttccaaac  tggtgtcta  ccggcagag  gaggaaggc  1560
gagcaagtg  agcagggct  agcaggagc  gtttctggc  agaagcacc  gcctgctgc  1620
agcggggca  cccctcata  gaggcccag  agggagccc  aaggcgtag  agccttgtt  1680
aagctgtga  caggagaag  ggtgcccac  agcttccag  tctccctga  ctgcctgct  1740
tatgccccac  1750



<210> 2239
<211> 476
<212> PRT
<213> Homo sapiens
<308> NP_065172
<400> 2239

Met Gly Arg Lys Glu Glu Asp Asp Cys Ser Ser Trp Lys Lys Gln Thr 
  1               5                  10                  15
Thr Asn Ile Arg Lys Thr Phe Ile Phe Met Glu Val Leu Gly Ser Gly 
             20                  25                  30
Ala Phe Ser Glu Val Phe Leu Val Lys Gln Arg Leu Thr Gly Lys Leu 
         35                  40                  45
Phe Ala Leu Lys Cys Ile Lys Lys Ser Pro Ala Phe Arg Asp Ser Ser 
     50                  55                  60
Leu Glu Asn Glu Ile Ala Val Leu Lys Lys Ile Lys His Glu Asn Ile 
 65                  70                  75                  80
Val Thr Leu Glu Asp Ile Tyr Glu Ser Thr Thr His Tyr Tyr Leu Val 
                 85                  90                  95
Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Leu Glu Arg 
             100                105                110
Gly Val Tyr Thr Glu Lys Asp Ala Ser Leu Val Ile Gln Gln Val Leu 
         115                120                125
Ser Ala Val Lys Tyr Leu His Glu Asn Gly Ile Val His Arg Asp Leu 
     130                135                140
Lys Pro Glu Asn Leu Leu Tyr Leu Thr Pro Glu Glu Asn Ser Lys Ile 
 145                150                155                160
Met Ile Thr Asp Phe Gly Leu Ser Lys Met Glu Gln Asn Gly Ile Met 
                 165                170                175
Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val Leu Ala 
             180                185                190
Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly Val Ile 
         195                200                205
Thr Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Glu Glu Thr Glu 
     210                215                220
Ser Lys Leu Phe Glu Lys Ile Lys Glu Gly Tyr Tyr Glu Phe Glu Ser 
 225                230                235                240
Pro Phe Trp Asp Asp Ile Ser Glu Ser Ala Lys Asp Phe Ile Cys His 
                 245                250                255
Leu Leu Glu Lys Asp Pro Asn Glu Arg Tyr Thr Cys Glu Lys Ala Leu 
             260                265                270
Ser His Pro Trp Ile Asp Gly Asn Thr Ala Leu His Arg Asp Ile Tyr 
         275                280                285
Pro Ser Val Ser Leu Gln Ile Gln Lys Asn Phe Ala Lys Ser Lys Trp 
     290                295                300
Arg Gln Ala Phe Asn Ala Ala Ala Val Val His His Met Arg Lys Leu 
 305                310                315                320
His Met Asn Leu His Ser Pro Gly Val Arg Pro Glu Val Glu Asn Arg 
                 325                330                335
Pro Pro Glu Thr Gln Ala Ser Glu Thr Ser Arg Pro Ser Ser Pro Glu 
             340                345                350
Ile Thr Ile Thr Glu Ala Pro Val Leu Asp His Ser Val Ala Leu Pro 
         355                360                365
Ala Leu Thr Gln Leu Pro Cys Gln His Gly Arg Arg Pro Thr Ala Pro 
     370                375                380
Gly Gly Arg Ser Leu Asn Cys Leu Val Asn Gly Ser Leu His Ile Ser 
 385                390                395                400
Ser Ser Leu Val Pro Met His Gln Gly Ser Leu Ala Ala Gly Pro Cys 
                 405                410                415
Gly Cys Cys Ser Ser Cys Leu Asn Ile Gly Ser Lys Gly Lys Ser Ser 
             420                425                430
Tyr Cys Ser Glu Pro Thr Leu Leu Lys Lys Ala Asn Lys Lys Gln Asn 
         435                440                445
Phe Lys Ser Glu Val Met Val Pro Val Lys Ala Ser Gly Ser Ser His 
     450                455                460
Cys Arg Ala Gly Gln Thr Gly Val Cys Leu Ile Met 
 465                470                475



<210> 2240
<211> 1013
<212> DNA
<213> Rattus norvegicus
<308> D86557
<400> 2240

ggagcaggc  cgctggcca  gatcacaga  tggagcacc  ttcttgtga  cccctggct  60
cccaggcag  ttcaactct  gaggacatg  ggcgaaagg  ggaggagga  tgtagctcc  120
ggaagaaac  gaccaccaa  atcaggaaa  ccttcatct  catggaagt  ctcggatca  180
gagcgttct  agaggtgtt  ctggtgaag  aaagagtga  tgggaaact  tttgctctg  240
agtgcatca  gaagtcacc  gccttccgg  acagtagcc  agagaatga  attgctgtg  300
tgaaaagga  caagcatga  aacattgtg  ccctggagg  tatctatga  agcaccacc  360
actactacc  ggtcatgca  cttgtttct  gaggtgagc  ttttgaccg  atcctagag  420
gtggtgtct  cacagaaaa  gatgccagt  tggtcatcc  gcaggtctt  tctgccgtg  480
aataccttc  tgagaatgg  atcgttcac  gagatctaa  gcctgaaaa  ctgctgtac  540
tcacccctg  ggagaactc  aagataatg  tcactgatt  tggcctatc  aagatggag  600
agaatggag  catgtccac  gcttgtggg  ccccaggct  tgtggctcc  gaagtgctg  660
cccagaagc  ctacagtaa  gctgtggac  gctggtcca  tggtgtcat  acatacata  720
tgctgtgtg  gtatccccc  ttctatgaa  aaacagaat  aaagctttt  gagaagatc  780
aagagggtt  ctacgagtt  gagtctcca  tctgggatg  catttctga  tcagccaag  840
actttattt  ccatctgct  gagaaggac  caaatgaac  atacacctg  gagaaagcc  900
tcagacacc  ttggattga  gggaacaca  ccctgcacc  ggacatcta  ccatctgtc  960
gcctccaga  tcagaagaa  tttgccaag  gcaagtgga  gcaagcctt  aat  1013



<210> 2241
<211> 309
<212> PRT
<213> Rattus norvegicus
<308> BAA19880
<400> 2241

Met Gly Arg Lys Glu Glu Glu Asp Cys Ser Ser Trp Lys Lys Gln Thr 
  1               5                  10                  15
Thr Asn Ile Arg Lys Thr Phe Ile Phe Met Glu Val Leu Gly Ser Gly 
             20                  25                  30
Ala Phe Ser Glu Val Phe Leu Val Lys Gln Arg Val Thr Gly Lys Leu 
         35                  40                  45
Phe Ala Leu Lys Cys Ile Lys Lys Ser Pro Ala Phe Arg Asp Ser Ser 
     50                  55                  60
Leu Glu Asn Glu Ile Ala Val Leu Lys Arg Ile Lys His Glu Asn Ile 
 65                  70                  75                  80
Val Thr Leu Glu Asp Ile Tyr Glu Ser Thr Thr His Tyr Tyr Leu Val 
                 85                  90                  95
Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Leu Glu Arg 
             100                105                110
Gly Val Tyr Thr Glu Lys Asp Ala Ser Leu Val Ile Gln Gln Val Leu 
         115                120                125
Ser Ala Val Lys Tyr Leu His Glu Asn Gly Ile Val His Arg Asp Leu 
     130                135                140
Lys Pro Glu Asn Leu Leu Tyr Leu Thr Pro Glu Glu Asn Ser Lys Ile 
 145                150                155                160
Met Ile Thr Asp Phe Gly Leu Ser Lys Met Glu Gln Asn Gly Val Met 
                 165                170                175
Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val Leu Ala 
             180                185                190
Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly Val Ile 
         195                200                205
Thr Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Glu Glu Thr Glu 
     210                215                220
Ser Lys Leu Phe Glu Lys Ile Lys Glu Gly Tyr Tyr Glu Phe Glu Ser 
 225                230                235                240
Pro Phe Trp Asp Asp Ile Ser Glu Ser Ala Lys Asp Phe Ile Cys His 
                 245                250                255
Leu Leu Glu Lys Asp Pro Asn Glu Arg Tyr Thr Cys Glu Lys Ala Leu 
             260                265                270
Arg His Pro Trp Ile Asp Gly Asn Thr Ala Leu His Arg Asp Ile Tyr 
         275                280                285
Pro Ser Val Ser Leu Gln Ile Gln Lys Asn Phe Ala Lys Ser Lys Trp 
     290                295                300
Arg Gln Ala Phe Asn 
 305



<210> 2242
<211> 1750
<212> DNA
<213> Homo sapiens
<308> NM_020439
<400> 2242

catcctcag  agcttcaac  ctggaggca  tgggtcgaa  ggaagaaga  gactgcagt  60
cctggaaga  acagaccac  aacatccgg  aaaccttca  ttttatgga  gtgctggga  120
caggagctt  ctcagaagt  ttcctggtg  agcaaagac  gactgggaa  ctctttgct  180
tgaagtgca  caagaagtc  cctgccttc  gggacagca  cctggagaa  gagattgct  240
tgttgaaaa  gatcaagca  gaaaacatt  tgaccctgg  ggacatcta  gagagcacc  300
cccactact  cctggtcat  cagcttgtt  ctggtgggg  gctctttga  cggatcctg  360
agcggggtg  ctacacaga  aaggatgcc  gtctggtga  ccagcaggt  ttgtcggca  420
tgaaatacc  acatgagaa  ggcatcgtc  acagagact  aaagcccga  aacctgctt  480
accttaccc  tgaagagaa  tctaagatc  tgatcactg  ctttggtct  tccaagatg  540
aacagaatg  catcatgtc  actgcctgt  ggaccccag  ctacgtggc  ccagaagtg  600
tggcccaga  accctacag  aaggctgtg  attgctggt  catcggcgt  atcacctac  660
tattgctct  tggataccc  ccattctat  aagaaacgg  gtctaagct  ttcgagaag  720
tcaaggagg  ctactatga  tttgagtct  cattctggg  tgacatttc  gagtcagcc  780
aggacttta  ttgccactt  cttgagaag  atccgaacg  gcggtacac  tgtgagaag  840
ccttgagtc  tccctggat  gacggaaac  cagccctcc  ccgggacat  tacccatca  900
tcagcctcc  gatccagaa  aactttgct  agagcaagt  gaggcaagc  ttcaacgca  960
cagctgtgg  gcaccacat  aggaagcta  acatgaacc  gcacagccc  ggcgtccgc  1020
cagaggtgg  gaacaggcc  cctgaaact  aagcctcag  aacctctag  cccagctcc  1080
ctgagatca  catcaccga  gcacctgtc  tggaccaca  tgtagcact  cctgccctg  1140
cccaattac  ctgccagca  ggccgccgg  ccactgccc  tggtggcag  tccctcaac  1200
gcctggtca  tggctccct  cacatcagc  gcagcctgg  gcccatgca  caggggtcc  1260
tggccgccg  gccctgtgg  tgctgctcc  gctgcctga  cattgggag  aaaggaaag  1320
cctcctact  ctctgagcc  acactcctc  aaaaggcca  caaaaaaca  aacttcaag  1380
cggaggtca  ggtaccagt  aaagccagt  gcagctccc  ctgccgggc  gggcagact  1440
gagtctgtc  cattatgtg  ttcctggag  ctgtgccta  gtcactgca  ttttcagga  1500
acatattca  ctcctctgc  cttccaaac  tggtgtcta  ccggcagag  gaggaaggc  1560
gagcaagtg  agcagggct  agcaggagc  gtttctggc  agaagcacc  gcctgctgc  1620
agcggggca  cccctcata  gaggcccag  agggagccc  aaggcgtag  agccttgtt  1680
aagctgtga  caggagaag  ggtgcccac  agcttccag  tctccctga  ctgcctgct  1740
tatgccccac  1750



<210> 2243
<211> 476
<212> PRT
<213> Homo sapiens
<308> NP_065172
<400> 2243

Met Gly Arg Lys Glu Glu Asp Asp Cys Ser Ser Trp Lys Lys Gln Thr 
  1               5                  10                  15
Thr Asn Ile Arg Lys Thr Phe Ile Phe Met Glu Val Leu Gly Ser Gly 
             20                  25                  30
Ala Phe Ser Glu Val Phe Leu Val Lys Gln Arg Leu Thr Gly Lys Leu 
         35                  40                  45
Phe Ala Leu Lys Cys Ile Lys Lys Ser Pro Ala Phe Arg Asp Ser Ser 
     50                  55                  60
Leu Glu Asn Glu Ile Ala Val Leu Lys Lys Ile Lys His Glu Asn Ile 
 65                  70                  75                  80
Val Thr Leu Glu Asp Ile Tyr Glu Ser Thr Thr His Tyr Tyr Leu Val 
                 85                  90                  95
Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Leu Glu Arg 
             100                105                110
Gly Val Tyr Thr Glu Lys Asp Ala Ser Leu Val Ile Gln Gln Val Leu 
         115                120                125
Ser Ala Val Lys Tyr Leu His Glu Asn Gly Ile Val His Arg Asp Leu 
     130                135                140
Lys Pro Glu Asn Leu Leu Tyr Leu Thr Pro Glu Glu Asn Ser Lys Ile 
 145                150                155                160
Met Ile Thr Asp Phe Gly Leu Ser Lys Met Glu Gln Asn Gly Ile Met 
                 165                170                175
Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val Leu Ala 
             180                185                190
Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly Val Ile 
         195                200                205
Thr Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Glu Glu Thr Glu 
     210                215                220
Ser Lys Leu Phe Glu Lys Ile Lys Glu Gly Tyr Tyr Glu Phe Glu Ser 
 225                230                235                240
Pro Phe Trp Asp Asp Ile Ser Glu Ser Ala Lys Asp Phe Ile Cys His 
                 245                250                255
Leu Leu Glu Lys Asp Pro Asn Glu Arg Tyr Thr Cys Glu Lys Ala Leu 
             260                265                270
Ser His Pro Trp Ile Asp Gly Asn Thr Ala Leu His Arg Asp Ile Tyr 
         275                280                285
Pro Ser Val Ser Leu Gln Ile Gln Lys Asn Phe Ala Lys Ser Lys Trp 
     290                295                300
Arg Gln Ala Phe Asn Ala Ala Ala Val Val His His Met Arg Lys Leu 
 305                310                315                320
His Met Asn Leu His Ser Pro Gly Val Arg Pro Glu Val Glu Asn Arg 
                 325                330                335
Pro Pro Glu Thr Gln Ala Ser Glu Thr Ser Arg Pro Ser Ser Pro Glu 
             340                345                350
Ile Thr Ile Thr Glu Ala Pro Val Leu Asp His Ser Val Ala Leu Pro 
         355                360                365
Ala Leu Thr Gln Leu Pro Cys Gln His Gly Arg Arg Pro Thr Ala Pro 
     370                375                380
Gly Gly Arg Ser Leu Asn Cys Leu Val Asn Gly Ser Leu His Ile Ser 
 385                390                395                400
Ser Ser Leu Val Pro Met His Gln Gly Ser Leu Ala Ala Gly Pro Cys 
                 405                410                415
Gly Cys Cys Ser Ser Cys Leu Asn Ile Gly Ser Lys Gly Lys Ser Ser 
             420                425                430
Tyr Cys Ser Glu Pro Thr Leu Leu Lys Lys Ala Asn Lys Lys Gln Asn 
         435                440                445
Phe Lys Ser Glu Val Met Val Pro Val Lys Ala Ser Gly Ser Ser His 
     450                455                460
Cys Arg Ala Gly Gln Thr Gly Val Cys Leu Ile Met 
 465                470                475



<210> 2244
<211> 327
<212> DNA
<213> Rattus norvegicus
<308> D86642
<400> 2244

atgggcgtg  agatcgaga  catctcccc  ggagacgga  ggacattcc  taagaaggg  60
cagatatgc  tggtgcact  cacagggat  ctccagaat  gcaagaaat  cgattcgtc  120
agagacaga  acaaaccct  caagttcag  attggcaag  aggaagtca  caaaggttt  180
gaagaaggc  ctgcccaga  gagcttggg  cagagggcg  agctgacct  cacccctga  240
gtggcatat  gagctactg  ccaccccgg  gtcatccct  ccaatgcca  cctcatctt  300
gacgtggag  tgctcaact  agagtga  327



<210> 2245
<211> 107
<212> PRT
<213> Rattus norvegicus
<308> P97534
<400> 2245

Gly Val Glu Ile Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
  1               5                  10                  15
Lys Lys Gly Gln Ile Cys Val Val His Tyr Thr Gly Met Leu Gln Asn 
             20                  25                  30
Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
         35                  40                  45
Arg Ile Gly Lys Gln Glu Val Ile Lys Gly Phe Glu Glu Gly Ala Ala 
     50                  55                  60
Gln Met Ser Leu Gly Gln Arg Ala Lys Leu Thr Cys Thr Pro Asp Val 
 65                  70                  75                  80
Ala Tyr Gly Ala Thr Gly His Pro Gly Val Ile Pro Pro Asn Ala Thr 
                 85                  90                  95
Leu Ile Phe Asp Val Glu Leu Leu Asn Leu Glu 
             100                105



<210> 2246
<211> 593
<212> DNA
<213> Homo sapiens
<308> AF322070
<400> 2246

agcagcagg  accccccag  ggcggggcc  gtgggaccg  tatgggcgt  gagatcgag  60
ccatctccc  cggagacgg  aggacattc  ccaagaagg  ccaaacgtg  gtggtgcac  120
acacaggaa  gctccaaaa  gggaagaag  ttgattcat  cagagacag  aacaaacct  180
tcaagttca  aattggcaa  caggaagtc  tcaaaggtt  tgaagaggg  gcagcccag  240
tgggtcctc  ttctcctct  cccatctgc  cccatccct  ctagatgag  ttggggcag  300
gggcgaagc  gacctgcac  cctgatgtg  catatggag  cacgggcca  cccggtgtc  360
tccctccca  tgccaccct  atctttgac  tggagctgc  caacttaga  tgaaggcag  420
aaggaactc  aggtggctg  agatggctg  tgctcaccc  cctagcctg  tctgccact  480
ggacggctc  tgcttttgg  gctcttgat  agtgtgcta  cctcactgc  tcatggcat  540
atccattct  tctgcccaa  ttgctctgt  tgtgttcgt  agtgttcat  cga  593



<210> 2247
<211> 107
<212> PRT
<213> Homo sapiens
<308> Q16645
<400> 2247

Gly Val Glu Ile Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
  1               5                  10                  15
Lys Lys Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gln Asn 
             20                  25                  30
Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
         35                  40                  45
Arg Ile Gly Lys Gln Glu Val Ile Lys Gly Phe Glu Glu Gly Ala Ala 
     50                  55                  60
Gln Met Ser Leu Gly Gln Arg Ala Lys Leu Thr Cys Thr Pro Asp Val 
 65                  70                  75                  80
Ala Tyr Gly Ala Thr Gly His Pro Gly Val Ile Pro Pro Asn Ala Thr 
                 85                  90                  95
Leu Ile Phe Asp Val Glu Leu Leu Asn Leu Glu 
             100                105



<210> 2248
<211> 994
<212> DNA
<213> Rattus norvegicus
<308> D86711
<400> 2248

acatctggg  ttctgtcag  taaaagaac  tggagagtt  ttaaactcc  tcacatcta  60
tttccccag  aaaggggtc  cagttccat  atggtggtg  gagatcngg  anagagctt  120
gccaaattt  agaaacacc  ggcagccct  ccctccatt  ttggaagac  gggattgtg  180
tgagcccct  caatgcttc  ctagaattt  cnggaaaat  ttaaaatcc  aggccagga  240
agaagaatc  aaaaaagca  tatttttca  catatgcca  naatgggat  ganagaagg  300
gtggcaggc  tangcccct  cgattgtcc  ttggggttt  ccccttagc  cacctcaat  360
tggtgctgg  tnnangggt  nctgggttc  aaccttaaa  agggaagac  cccgcctct  420
tacagagac  ctttaattt  tttattctg  ttagccntc  ttaaaccan  aaanaatna  480
atnnatcct  atctaaaac  tctgggatt  tgtcagata  aagaacttg  agagttttt  540
aactccttc  catctaatt  ccccaggaa  ggggtcaca  ttccatgat  gtggtggga  600
atcnggaan  gagcttggc  aaatttaag  aacaccagg  agccctgcc  tccattctt  660
gaagacagg  attgtggtg  gccccttca  tgcttccct  gaatttacn  gaaaatctt  720
aaatccaag  ccaggagag  agaatccaa  aaagcaata  ttttcatca  atgccanna  780
tgggataga  agaaggagt  gcaggccta  gcccctccg  ttgtccctt  gggtttacc  840
cttagccca  ctcaatatg  tgctgggtn  angggtanc  gggttctaa  cttaaacag  900
gaagactcc  gcctctata  agagaccct  taatttttt  attctgatt  gccntcttt  960
aaccancaa  naatnaaat  natcctnat  taaa  994



<210> 2250
<211> 2148
<212> DNA
<213> Rattus norvegicus
<308> D87240
<400> 2250

gaggctgac  cgccgcgct  ccggtcaga  cttaaaagg  cgggcagtg  gtgtggcat  60
ccgacagaa  aggagagga  caagtggca  cgcccggtg  tgggagcgt  gctgtcact  120
cgctggagc  tccctgagc  tctgaacag  gccgggtag  cagcagtgc  gcagccgca  180
ctccacgcc  agccgagct  aatctgtct  gtgtctccg  tccggcgat  ctccgagac  240
ccgcacaaa  cacattttc  aaagcagcg  aagggagcg  ccagccgcg  gcaggcgga  300
gcacccttc  tgtcctttg  tccgggggg  atctgcagc  gctcttctc  cccaactcg  360
agtcttccc  ccaggggtg  caggtcgcc  aatacagca  cgaagatgc  tttggaact  420
acccagagc  gggtgcaga  gatctgggt  cctgtcgat  accgaccct  gttgcccag  480
tcctgtggg  cgaagctga  caactcccc  acggtgatt  tgatggtgg  gctcccagc  540
cggggtaag  cttacatct  caagaagct  actcgctac  tcaactgga  aggtgttcc  600
acgaaagtg  tcaatgtgg  agaataccg  cgggaggct  tgaagcaat  cagctctta  660
aacttcttc  gccctgaca  tgaggaggc  atgagagtc  gaaaacagt  tgccttagc  720
gccctgaga  acgtcaaaa  ctacctgac  aaggaagga  gacagattg  agtttttga  780
gccaccaat  cgacgagag  aaggaggca  atgatcctt  attttgcca  agaaaatga  840
ttcaaggca  ttttcatcg  gtccgtctg  gacgaccct  cagttgtgg  ctccaatat  900
atggaagtg  aaatctcca  cccggatta  aaagactgc  actccgcag  agccatgga  960
gacttcatg  agaggatca  ctgctacga  gccagctac  agcctcttg  ccctgataa  1020
tgtgacagg  acctgtcat  catcaaagt  attgacgtt  gccggaggt  cttggtgaa  1080
agagtgcag  accacatcc  gagccgaat  gtgtattac  tgatgaaca  ccacgtgca  1140
ccccggacc  tctacctgt  tcggcacgg  gagaatgag  acaacgtgc  gggcaagat  1200
gggggcgac  caggcctgt  cagcagagg  aagaagttc  ccaatgccc  gagcaagtt  1260
gttgaagag  agaatctga  ggacctccg  gtgtggacc  gtcagctga  aagtaccat  1320
cagaccgcg  aggccctaa  gctccccta  gagcagtgg  aggcgctca  tgagattga  1380
gctggtgtg  gtgaggaac  aacctatga  gagatcaga  acacctacc  tgaggagta  1440
gcactgcgt  agcaagaca  atactacta  cgctatccc  caggcgagt  ctaccagga  1500
cttgtccag  gcctggagc  tgtgatcat  gaattagag  gccaagaga  cgtattggt  1560
atctgtcac  aggctgtcc  gcgctgcct  ctagcctac  tccttgaca  gagtgcaga  1620
gagatgcca  acctgaaat  cccacttca  acagtcctg  aactgacgc  cgtggcgta  1680
gggtgccgt  tggagtcca  ttacttgaa  gtagaatca  tgagcacgc  tcgggagag  1740
tcagaggct  tcaaaatac  acactttgc  agtgtagtc  gaccttcct  ttacaccga  1800
cttgacttt  tgtctgtgg  gtccgcaaa  caggatgca  agaagggac  taaccctct  1860
atgagacgc  atagtgtca  cccactagc  agccccgag  ccaccaaaa  gcctcgcat  1920
aacagcttt  aggagcatg  ggcttccac  tctgctgcc  tgccaagct  cctgccccc  1980
gaagtgccc  cgcagctgc  cggacaacc  ttgctaggg  aagcctgtc  acgaactgt  2040
tgtcacatt  tttcaaagt  ttctcctta  taacctggg  aagaacatg  ggagccccc  2100
gagcggtgc  gaatcttcc  agaagcact  atgctgaag  aggggttc  2148



<210> 2251
<211> 555
<212> PRT
<213> Rattus norvegicus
<308> O35096
<400> 2251

Met Pro Leu Glu Leu Thr Gln Ser Arg Val Gln Lys Ile Trp Val Pro 
  1               5                  10                  15
Val Asp His Arg Pro Ser Leu Pro Arg Ser Cys Gly Pro Lys Leu Thr 
             20                  25                  30
Asn Ser Pro Thr Val Ile Val Met Val Gly Leu Pro Ala Arg Gly Lys 
         35                  40                  45
Thr Tyr Ile Ser Lys Lys Leu Thr Arg Tyr Leu Asn Trp Ile Gly Val 
     50                  55                  60
Pro Thr Lys Val Phe Asn Val Gly Glu Tyr Arg Arg Glu Ala Val Lys 
 65                  70                  75                  80
Gln Tyr Ser Ser Tyr Asn Phe Phe Arg Pro Asp Asn Glu Glu Ala Met 
                 85                  90                  95
Arg Val Arg Lys Gln Cys Ala Leu Ala Ala Leu Arg Asp Val Lys Ser 
             100                105                110
Tyr Leu Thr Lys Glu Gly Gly Gln Ile Ala Val Phe Asp Ala Thr Asn 
         115                120                125
Thr Thr Arg Glu Arg Arg His Met Ile Leu His Phe Ala Lys Glu Asn 
     130                135                140
Asp Phe Lys Ala Phe Phe Ile Glu Ser Val Cys Asp Asp Pro Thr Val 
 145                150                155                160
Val Ala Ser Asn Ile Met Glu Val Lys Ile Ser Ser Pro Asp Tyr Lys 
                 165                170                175
Asp Cys Asn Ser Ala Glu Ala Met Asp Asp Phe Met Lys Arg Ile Asn 
             180                185                190
Cys Tyr Glu Ala Ser Tyr Gln Pro Leu Asp Pro Asp Lys Cys Asp Arg 
         195                200                205
Asp Leu Ser Phe Ile Lys Val Ile Asp Val Gly Arg Arg Phe Leu Val 
     210                215                220
Asn Arg Val Gln Asp His Ile Gln Ser Arg Ile Val Tyr Tyr Leu Met 
 225                230                235                240
Asn Ile His Val Gln Pro Arg Thr Ile Tyr Leu Cys Arg His Gly Glu 
                 245                250                255
Asn Glu Tyr Asn Val Gln Gly Lys Ile Gly Gly Asp Ser Gly Leu Ser 
             260                265                270
Ser Arg Gly Lys Lys Phe Ala Asn Ala Leu Ser Lys Phe Val Glu Glu 
         275                280                285
Gln Asn Leu Lys Asp Leu Arg Val Trp Thr Ser Gln Leu Lys Ser Thr 
     290                295                300
Ile Gln Thr Ala Glu Ala Leu Arg Leu Pro Tyr Glu Gln Trp Lys Ala 
 305                310                315                320
Leu Asn Glu Ile Asp Ala Gly Val Cys Glu Glu Leu Thr Tyr Glu Glu 
                 325                330                335
Ile Arg Asp Thr Tyr Pro Glu Glu Tyr Ala Leu Arg Glu Gln Asp Lys 
             340                345                350
Tyr Tyr Tyr Arg Tyr Pro Thr Gly Glu Ser Tyr Gln Asp Leu Val Gln 
         355                360                365
Arg Leu Glu Pro Val Ile Met Glu Leu Glu Arg Gln Glu Asn Val Leu 
     370                375                380
Val Ile Cys His Gln Ala Val Leu Arg Cys Leu Leu Ala Tyr Phe Leu 
 385                390                395                400
Asp Lys Ser Ala Glu Glu Met Pro Tyr Leu Lys Cys Pro Leu His Thr 
                 405                410                415
Val Leu Lys Leu Thr Pro Val Ala Tyr Gly Cys Arg Val Glu Ser Ile 
             420                425                430
Tyr Leu Asn Val Glu Ser Val Ser Thr His Arg Glu Arg Ser Glu Ala 
         435                440                445
Val Lys Ile Gln His Phe Ala Ser Val Val Arg Pro Ser Ser Tyr Thr 
     450                455                460
Glu Leu Asp Phe Leu Ser Val Glu Ser Ala Lys Gln Asp Ala Lys Lys 
 465                470                475                480
Gly Pro Asn Pro Leu Met Arg Arg Asn Ser Val Thr Pro Leu Ala Ser 
                 485                490                495
Pro Glu Pro Thr Lys Lys Pro Arg Ile Asn Ser Phe Glu Glu His Val 
             500                505                510
Ala Ser Thr Ser Ala Ala Leu Pro Ser Cys Leu Pro Pro Glu Val Pro 
         515                520                525
Thr Gln Leu Pro Gly Gln Pro Leu Leu Gly Lys Ala Cys Leu Arg Thr 
     530                535                540
Val Cys His Ile Phe Ser Lys Phe Ser Pro Tyr 
 545                550                555



<210> 2252
<211> 513
<212> DNA
<213> Homo sapiens
<308> AJ295747
<400> 2252

atctacctg  acgtggagt  cgtctgcac  caccgggag  ggtcagagg  tgcaaagaa  60
ggacctaac  cgctcatga  acgcaatag  gtcaccccg  tagccagcc  cgaacccac  120
aaaaagcct  gcatcaaca  ctttgagga  catgtggcc  ccacctcgg  cgccctgcc  180
agctgcctg  ccccggagg  gcccacgca  ctgcctgga  aacctttgc  agggcaagc  240
tgtctaaac  ggaaaggtg  gatgaggaa  gcagcctga  atgctgaaa  gaatgactg  300
ctttggaaa  gggagagaa  atgaaaggc  cccggagca  cgctgactc  tccaggaaa  360
actgaggca  acgtgtcgg  tccattcca  ttccatttc  gcagcttag  ttgtgtcct  420
ccctccgcc  gaggcaaaa  gtatcctga  gacttcttc  ggagagggt  gggtggagc  480
gcgggggag  cttggccga  gagaaccat  ctt  513



<210> 2253
<211> 520
<212> PRT
<213> Homo sapiens
<308> Q16875
<400> 2253

Met Pro Leu Glu Leu Thr Gln Ser Arg Val Gln Lys Ile Trp Val Pro 
  1               5                  10                  15
Val Asp His Arg Pro Ser Leu Pro Arg Ser Cys Gly Pro Lys Leu Thr 
             20                  25                  30
Asn Ser Pro Thr Val Ile Val Met Val Gly Leu Pro Ala Arg Gly Lys 
         35                  40                  45
Thr Tyr Ile Ser Lys Lys Leu Thr Arg Tyr Leu Asn Trp Ile Gly Val 
     50                  55                  60
Pro Thr Lys Val Phe Asn Val Gly Glu Tyr Arg Arg Glu Ala Val Lys 
 65                  70                  75                  80
Gln Tyr Ser Ser Tyr Asn Phe Phe Arg Pro Asp Asn Glu Glu Ala Met 
                 85                  90                  95
Lys Val Arg Lys Gln Cys Ala Leu Ala Ala Leu Arg Asp Val Lys Ser 
             100                105                110
Tyr Leu Ala Lys Glu Gly Gly Gln Ile Ala Val Phe Asp Ala Thr Asn 
         115                120                125
Thr Thr Arg Glu Arg Arg His Met Ile Leu His Phe Ala Lys Glu Asn 
     130                135                140
Asp Phe Lys Ala Phe Phe Ile Glu Ser Val Cys Asp Asp Pro Thr Val 
 145                150                155                160
Val Ala Ser Asn Ile Met Glu Val Lys Ile Ser Ser Pro Asp Tyr Lys 
                 165                170                175
Asp Cys Asn Ser Ala Glu Ala Met Asp Asp Phe Met Lys Arg Ile Ser 
             180                185                190
Cys Tyr Glu Ala Ser Tyr Gln Pro Leu Asp Pro Asp Lys Cys Asp Arg 
         195                200                205
Asp Leu Ser Leu Ile Lys Val Ile Asp Val Gly Arg Arg Phe Leu Val 
     210                215                220
Asn Arg Val Gln Asp His Ile Gln Ser Arg Ile Val Tyr Tyr Leu Met 
 225                230                235                240
Asn Ile His Val Gln Pro Arg Thr Ile Tyr Leu Cys Arg His Gly Glu 
                 245                250                255
Asn Glu His Asn Leu Gln Gly Arg Ile Gly Gly Asp Ser Gly Leu Ser 
             260                265                270
Ser Arg Gly Lys Lys Phe Ala Ser Ala Leu Ser Lys Phe Val Glu Glu 
         275                280                285
Gln Asn Leu Lys Asp Leu Arg Val Trp Thr Ser Gln Leu Lys Ser Thr 
     290                295                300
Ile Gln Thr Ala Glu Ala Leu Arg Leu Pro Tyr Glu Gln Trp Lys Ala 
 305                310                315                320
Leu Asn Glu Ile Asp Ala Gly Val Cys Glu Glu Leu Thr Tyr Glu Glu 
                 325                330                335
Ile Arg Asp Thr Tyr Pro Glu Glu Tyr Ala Leu Arg Glu Gln Asp Lys 
             340                345                350
Tyr Tyr Tyr Arg Tyr Pro Thr Gly Glu Ser Tyr Gln Asp Leu Val Gln 
         355                360                365
Arg Leu Glu Pro Val Ile Met Glu Leu Glu Arg Gln Glu Asn Val Leu 
     370                375                380
Val Ile Cys His Gln Ala Val Leu Arg Cys Leu Leu Ala Tyr Phe Leu 
 385                390                395                400
Asp Lys Ser Ala Glu Glu Met Pro Tyr Leu Lys Cys Pro Leu His Thr 
                 405                410                415
Val Leu Lys Leu Thr Pro Val Ala Tyr Gly Cys Arg Val Glu Ser Ile 
             420                425                430
Tyr Leu Asn Val Glu Ser Val Cys Thr His Arg Glu Arg Ser Glu Asp 
         435                440                445
Ala Lys Lys Gly Pro Asn Pro Leu Met Arg Arg Asn Ser Val Thr Pro 
     450                455                460
Leu Ala Ser Pro Glu Pro Thr Lys Lys Pro Arg Ile Asn Ser Phe Glu 
 465                470                475                480
Glu His Val Ala Ser Thr Ser Ala Ala Leu Pro Ser Cys Leu Pro Pro 
                 485                490                495
Glu Val Pro Thr Gln Leu Pro Gly Gln Asn Met Lys Gly Ser Arg Ser 
             500                505                510
Ser Ala Asp Ser Ser Arg Lys His 
         515                520



<210> 2254
<211> 1156
<212> DNA
<213> Rattus norvegicus
<308> D87991
<400> 2254

cctggagct  tcgccttcg  ctccggtac  gctacctgt  ctgaacgga  ctccggccg  60
ctcgtccct  cgtctcatg  ccgctagca  atccctggt  cccgaccgg  tgcgcctac  120
actctgctt  ttgggtgtc  ttgtctgct  cttctacta  gggatcctg  aggagaaga  180
aacaagagg  aagtatgga  aaggaccca  acaggagac  ttcaccttt  ccttaactt  240
ggttttcat  cagtgtgtg  tcaatgcta  gtttgccaa  atcttgatc  agttttttg  300
cactgccag  gtggatcgc  ctcggacct  gctctatgc  gcctgctct  tctcctatg  360
gggcgccat  gtctccagc  actcagcac  acagtttgt  aactatcca  ctcaggtcc  420
tggtaaatc  tgcaagcca  tcccagtta  gctcctcgg  gtgaccctc  tgaagaaga  480
gtacccatt  gccaagtac  tgtgtgtgt  gctaattgt  gctggcgtg  ctcttttca  540
gtataagcc  aagaaggtg  ttgggatag  agagcacac  gtcggcttt  gagagctcc  600
tctgctctt  tctctgacc  tggatggac  gacaggtgt  tcccaggac  atatgcggg  660
tcattacca  acaggttcc  atcacatga  gttgaacat  aacctttgg  ccacggtct  720
gctcggtgc  gggatcctg  ttactgggg  gctctggga  ttcttgagt  tcgccgaga  780
gtacccgac  atcatctat  acatcctgc  ctttggctt  accagtgcc  tgggtcaga  840
ctttatctt  atgacagtc  tgtacttcg  ccccctgac  tgctccatc  tcaccacga  900
tcggaagtt  ttcaccatc  tggcttctg  gatcctctt  gccaatccc  tcagctcca  960
gcagtgggt  ggcaccgtg  tggttttcc  gggtctggg  cttgatgcc  agtttggga  1020
aggaacaaa  aagacctcc  actaggaaa  gagaggctt  ctccactcc  gaaacactt  1080
aattattat  tccaacagt  acatcttgg  aaaatggac  cagtcacga  aagggactg  1140
gttccaatc  ttttat  1156



<210> 2255
<211> 322
<212> PRT
<213> Rattus norvegicus
<308> BAA13527
<400> 2255

Met Ala Ala Ser Arg Ser Leu Val Pro Asp Arg Leu Arg Leu Pro Leu 
  1               5                  10                  15
Cys Phe Leu Gly Val Phe Val Cys Tyr Phe Tyr Tyr Gly Ile Leu Gln 
             20                  25                  30
Glu Lys Ile Thr Arg Gly Lys Tyr Gly Glu Gly Pro Lys Gln Glu Thr 
         35                  40                  45
Phe Thr Phe Ala Leu Thr Leu Val Phe Ile Gln Cys Val Ile Asn Ala 
     50                  55                  60
Met Phe Ala Lys Ile Leu Ile Gln Phe Phe Asp Thr Ala Arg Val Asp 
 65                  70                  75                  80
Arg Thr Arg Thr Trp Leu Tyr Ala Ala Cys Ser Val Ser Tyr Val Gly 
                 85                  90                  95
Ala Met Val Ser Ser Asn Ser Ala Leu Gln Phe Val Asn Tyr Pro Thr 
             100                105                110
Gln Val Leu Gly Lys Ser Cys Lys Pro Ile Pro Val Met Leu Leu Gly 
         115                120                125
Val Thr Leu Leu Lys Lys Lys Tyr Pro Leu Ala Lys Tyr Leu Cys Val 
     130                135                140
Leu Leu Ile Val Ala Gly Val Ala Leu Phe Met Tyr Lys Pro Lys Lys 
 145                150                155                160
Val Val Gly Ile Glu Glu His Thr Val Gly Phe Gly Glu Leu Leu Leu 
                 165                170                175
Leu Leu Ser Leu Thr Leu Asp Gly Leu Thr Gly Val Ser Gln Asp His 
             180                185                190
Met Arg Ala His Tyr Gln Thr Gly Ser Asn His Met Met Leu Asn Ile 
         195                200                205
Asn Leu Trp Ser Thr Val Leu Leu Gly Ala Gly Ile Leu Phe Thr Gly 
     210                215                220
Glu Leu Trp Glu Phe Leu Ser Phe Ala Glu Arg Tyr Pro Thr Ile Ile 
 225                230                235                240
Tyr Asn Ile Leu Leu Phe Gly Leu Thr Ser Ala Leu Gly Gln Ser Phe 
                 245                250                255
Ile Phe Met Thr Val Val Tyr Phe Gly Pro Leu Thr Cys Ser Ile Ile 
             260                265                270
Thr Thr Thr Arg Lys Phe Phe Thr Ile Leu Ala Ser Val Ile Leu Phe 
         275                280                285
Ala Asn Pro Ile Ser Ser Met Gln Trp Val Gly Thr Val Leu Val Phe 
     290                295                300
Leu Gly Leu Gly Leu Asp Ala Lys Phe Gly Lys Gly Thr Lys Lys Thr 
 305                310                315                320
Ser His 
                 325



<210> 2256
<211> 1186
<212> DNA
<213> Homo sapiens
<308> NM_005827
<400> 2256

gatgtccgg  tggagctgt  gcctccgcc  ccgctgctg  cggtgccgg  tgtgagcgg  60
tctccagtc  gctcctctg  gcgtctcat  gcctctagc  gctccctgg  gcccgaccg  120
ctgcgcctg  cgctctgct  cctgggtgt  tttgtctgc  atttttact  tgggatcct  180
caggaaaag  taacaagag  aaagtatgg  gaaggagcc  agcaggaga  gttcacctt  240
gccttaact  tggtcttca  tcaatgtgt  atcaatgct  tgtttgcca  gatcttgat  300
cagtttttt  acactgcca  ggtggatcg  acccggagc  ggctctatg  tgcctgttc  360
atctcctat  tgggtgcca  ggtctccag  aattcagca  tacagtttg  caactaccc  420
actcaggtc  ttggtaaat  ctgcaagcc  atcccagtc  tgctccttg  ggtgaccct  480
ttgaagaag  agtacccgt  ggccaagta  ctgtgtgtg  tgttaattg  ggctggagt  540
gcccttttc  tgtacaaac  caagaaagt  gttgggata  aagaacaca  agtcggcta  600
ggagagcta  tcttgctat  atcgctgac  ctggatgga  tgactggtg  ttcccagga  660
cacatgcgg  ctcattacc  aacaggctc  aaccacatg  tgctgaaca  caacctttg  720
tcgacattg  tgctgggaa  gggaatcct  ttcactggg  agctctggg  gttcttgag  780
tttgctgaa  ggtaccctg  catcatcta  aacatcctg  tctttgggc  gaccagtgc  840
ctgggtcag  gcttcatct  tatgacggt  gtgtatttt  gtcccctga  ctgctccat  900
atcactaca  ctcgaaagt  cttcacaat  ttggcctct  tgatcctct  cgccaatcc  960
atcagcccc  tgcagtggg  gggcactgt  cttgtgttc  tgggtcttg  tcttgatgc  1020
aagtttggg  aaggagcta  gaagacatc  cactaggaa  agagagact  cctccacat  1080
aagaatatt  aagttatta  ctcaaacag  gacatctct  gggaaaatg  acttaatag  1140
aatatggga  tgagttcca  tctttttta  taaaataaa  tcaagc  1186



<210> 2257
<211> 322
<212> PRT
<213> Homo sapiens
<308> NP_005818
<400> 2257

Met Ala Ser Ser Ser Ser Leu Val Pro Asp Arg Leu Arg Leu Pro Leu 
  1               5                  10                  15
Cys Phe Leu Gly Val Phe Val Cys Tyr Phe Tyr Tyr Gly Ile Leu Gln 
             20                  25                  30
Glu Lys Ile Thr Arg Gly Lys Tyr Gly Glu Gly Ala Lys Gln Glu Thr 
         35                  40                  45
Phe Thr Phe Ala Leu Thr Leu Val Phe Ile Gln Cys Val Ile Asn Ala 
     50                  55                  60
Val Phe Ala Lys Ile Leu Ile Gln Phe Phe Asp Thr Ala Arg Val Asp 
 65                  70                  75                  80
Arg Thr Arg Ser Trp Leu Tyr Ala Ala Cys Ser Ile Ser Tyr Leu Gly 
                 85                  90                  95
Ala Met Val Ser Ser Asn Ser Ala Leu Gln Phe Val Asn Tyr Pro Thr 
             100                105                110
Gln Val Leu Gly Lys Ser Cys Lys Pro Ile Pro Val Met Leu Leu Gly 
         115                120                125
Val Thr Leu Leu Lys Lys Lys Tyr Pro Leu Ala Lys Tyr Leu Cys Val 
     130                135                140
Leu Leu Ile Val Ala Gly Val Ala Leu Phe Met Tyr Lys Pro Lys Lys 
 145                150                155                160
Val Val Gly Ile Glu Glu His Thr Val Gly Tyr Gly Glu Leu Leu Leu 
                 165                170                175
Leu Leu Ser Leu Thr Leu Asp Gly Leu Thr Gly Val Ser Gln Asp His 
             180                185                190
Met Arg Ala His Tyr Gln Thr Gly Ser Asn His Met Met Leu Asn Ile 
         195                200                205
Asn Leu Trp Ser Thr Leu Leu Leu Gly Met Gly Ile Leu Phe Thr Gly 
     210                215                220
Glu Leu Trp Glu Phe Leu Ser Phe Ala Glu Arg Tyr Pro Ala Ile Ile 
 225                230                235                240
Tyr Asn Ile Leu Leu Phe Gly Leu Thr Ser Ala Leu Gly Gln Ser Phe 
                 245                250                255
Ile Phe Met Thr Val Val Tyr Phe Gly Pro Leu Thr Cys Ser Ile Ile 
             260                265                270
Thr Thr Thr Arg Lys Phe Phe Thr Ile Leu Ala Ser Val Ile Leu Phe 
         275                280                285
Ala Asn Pro Ile Ser Pro Met Gln Trp Val Gly Thr Val Leu Val Phe 
     290                295                300
Leu Gly Leu Gly Leu Asp Ala Lys Phe Gly Lys Gly Ala Lys Lys Thr 
 305                310                315                320
Ser His 
                 325



<210> 2258
<211> 1156
<212> DNA
<213> Rattus norvegicus
<308> D87991
<400> 2258

cctggagct  tcgccttcg  ctccggtac  gctacctgt  ctgaacgga  ctccggccg  60
ctcgtccct  cgtctcatg  ccgctagca  atccctggt  cccgaccgg  tgcgcctac  120
actctgctt  ttgggtgtc  ttgtctgct  cttctacta  gggatcctg  aggagaaga  180
aacaagagg  aagtatgga  aaggaccca  acaggagac  ttcaccttt  ccttaactt  240
ggttttcat  cagtgtgtg  tcaatgcta  gtttgccaa  atcttgatc  agttttttg  300
cactgccag  gtggatcgc  ctcggacct  gctctatgc  gcctgctct  tctcctatg  360
gggcgccat  gtctccagc  actcagcac  acagtttgt  aactatcca  ctcaggtcc  420
tggtaaatc  tgcaagcca  tcccagtta  gctcctcgg  gtgaccctc  tgaagaaga  480
gtacccatt  gccaagtac  tgtgtgtgt  gctaattgt  gctggcgtg  ctcttttca  540
gtataagcc  aagaaggtg  ttgggatag  agagcacac  gtcggcttt  gagagctcc  600
tctgctctt  tctctgacc  tggatggac  gacaggtgt  tcccaggac  atatgcggg  660
tcattacca  acaggttcc  atcacatga  gttgaacat  aacctttgg  ccacggtct  720
gctcggtgc  gggatcctg  ttactgggg  gctctggga  ttcttgagt  tcgccgaga  780
gtacccgac  atcatctat  acatcctgc  ctttggctt  accagtgcc  tgggtcaga  840
ctttatctt  atgacagtc  tgtacttcg  ccccctgac  tgctccatc  tcaccacga  900
tcggaagtt  ttcaccatc  tggcttctg  gatcctctt  gccaatccc  tcagctcca  960
gcagtgggt  ggcaccgtg  tggttttcc  gggtctggg  cttgatgcc  agtttggga  1020
aggaacaaa  aagacctcc  actaggaaa  gagaggctt  ctccactcc  gaaacactt  1080
aattattat  tccaacagt  acatcttgg  aaaatggac  cagtcacga  aagggactg  1140
gttccaatc  ttttat  1156



<210> 2259
<211> 322
<212> PRT
<213> Rattus norvegicus
<308> BAA13527
<400> 2259

Met Ala Ala Ser Arg Ser Leu Val Pro Asp Arg Leu Arg Leu Pro Leu 
  1               5                  10                  15
Cys Phe Leu Gly Val Phe Val Cys Tyr Phe Tyr Tyr Gly Ile Leu Gln 
             20                  25                  30
Glu Lys Ile Thr Arg Gly Lys Tyr Gly Glu Gly Pro Lys Gln Glu Thr 
         35                  40                  45
Phe Thr Phe Ala Leu Thr Leu Val Phe Ile Gln Cys Val Ile Asn Ala 
     50                  55                  60
Met Phe Ala Lys Ile Leu Ile Gln Phe Phe Asp Thr Ala Arg Val Asp 
 65                  70                  75                  80
Arg Thr Arg Thr Trp Leu Tyr Ala Ala Cys Ser Val Ser Tyr Val Gly 
                 85                  90                  95
Ala Met Val Ser Ser Asn Ser Ala Leu Gln Phe Val Asn Tyr Pro Thr 
             100                105                110
Gln Val Leu Gly Lys Ser Cys Lys Pro Ile Pro Val Met Leu Leu Gly 
         115                120                125
Val Thr Leu Leu Lys Lys Lys Tyr Pro Leu Ala Lys Tyr Leu Cys Val 
     130                135                140
Leu Leu Ile Val Ala Gly Val Ala Leu Phe Met Tyr Lys Pro Lys Lys 
 145                150                155                160
Val Val Gly Ile Glu Glu His Thr Val Gly Phe Gly Glu Leu Leu Leu 
                 165                170                175
Leu Leu Ser Leu Thr Leu Asp Gly Leu Thr Gly Val Ser Gln Asp His 
             180                185                190
Met Arg Ala His Tyr Gln Thr Gly Ser Asn His Met Met Leu Asn Ile 
         195                200                205
Asn Leu Trp Ser Thr Val Leu Leu Gly Ala Gly Ile Leu Phe Thr Gly 
     210                215                220
Glu Leu Trp Glu Phe Leu Ser Phe Ala Glu Arg Tyr Pro Thr Ile Ile 
 225                230                235                240
Tyr Asn Ile Leu Leu Phe Gly Leu Thr Ser Ala Leu Gly Gln Ser Phe 
                 245                250                255
Ile Phe Met Thr Val Val Tyr Phe Gly Pro Leu Thr Cys Ser Ile Ile 
             260                265                270
Thr Thr Thr Arg Lys Phe Phe Thr Ile Leu Ala Ser Val Ile Leu Phe 
         275                280                285
Ala Asn Pro Ile Ser Ser Met Gln Trp Val Gly Thr Val Leu Val Phe 
     290                295                300
Leu Gly Leu Gly Leu Asp Ala Lys Phe Gly Lys Gly Thr Lys Lys Thr 
 305                310                315                320
Ser His 
                 325



<210> 2260
<211> 1186
<212> DNA
<213> Homo sapiens
<308> NM_005827
<400> 2260

gatgtccgg  tggagctgt  gcctccgcc  ccgctgctg  cggtgccgg  tgtgagcgg  60
tctccagtc  gctcctctg  gcgtctcat  gcctctagc  gctccctgg  gcccgaccg  120
ctgcgcctg  cgctctgct  cctgggtgt  tttgtctgc  atttttact  tgggatcct  180
caggaaaag  taacaagag  aaagtatgg  gaaggagcc  agcaggaga  gttcacctt  240
gccttaact  tggtcttca  tcaatgtgt  atcaatgct  tgtttgcca  gatcttgat  300
cagtttttt  acactgcca  ggtggatcg  acccggagc  ggctctatg  tgcctgttc  360
atctcctat  tgggtgcca  ggtctccag  aattcagca  tacagtttg  caactaccc  420
actcaggtc  ttggtaaat  ctgcaagcc  atcccagtc  tgctccttg  ggtgaccct  480
ttgaagaag  agtacccgt  ggccaagta  ctgtgtgtg  tgttaattg  ggctggagt  540
gcccttttc  tgtacaaac  caagaaagt  gttgggata  aagaacaca  agtcggcta  600
ggagagcta  tcttgctat  atcgctgac  ctggatgga  tgactggtg  ttcccagga  660
cacatgcgg  ctcattacc  aacaggctc  aaccacatg  tgctgaaca  caacctttg  720
tcgacattg  tgctgggaa  gggaatcct  ttcactggg  agctctggg  gttcttgag  780
tttgctgaa  ggtaccctg  catcatcta  aacatcctg  tctttgggc  gaccagtgc  840
ctgggtcag  gcttcatct  tatgacggt  gtgtatttt  gtcccctga  ctgctccat  900
atcactaca  ctcgaaagt  cttcacaat  ttggcctct  tgatcctct  cgccaatcc  960
atcagcccc  tgcagtggg  gggcactgt  cttgtgttc  tgggtcttg  tcttgatgc  1020
aagtttggg  aaggagcta  gaagacatc  cactaggaa  agagagact  cctccacat  1080
aagaatatt  aagttatta  ctcaaacag  gacatctct  gggaaaatg  acttaatag  1140
aatatggga  tgagttcca  tctttttta  taaaataaa  tcaagc  1186



<210> 2261
<211> 322
<212> PRT
<213> Homo sapiens
<308> NP_005818
<400> 2261

Met Ala Ser Ser Ser Ser Leu Val Pro Asp Arg Leu Arg Leu Pro Leu 
  1               5                  10                  15
Cys Phe Leu Gly Val Phe Val Cys Tyr Phe Tyr Tyr Gly Ile Leu Gln 
             20                  25                  30
Glu Lys Ile Thr Arg Gly Lys Tyr Gly Glu Gly Ala Lys Gln Glu Thr 
         35                  40                  45
Phe Thr Phe Ala Leu Thr Leu Val Phe Ile Gln Cys Val Ile Asn Ala 
     50                  55                  60
Val Phe Ala Lys Ile Leu Ile Gln Phe Phe Asp Thr Ala Arg Val Asp 
 65                  70                  75                  80
Arg Thr Arg Ser Trp Leu Tyr Ala Ala Cys Ser Ile Ser Tyr Leu Gly 
                 85                  90                  95
Ala Met Val Ser Ser Asn Ser Ala Leu Gln Phe Val Asn Tyr Pro Thr 
             100                105                110
Gln Val Leu Gly Lys Ser Cys Lys Pro Ile Pro Val Met Leu Leu Gly 
         115                120                125
Val Thr Leu Leu Lys Lys Lys Tyr Pro Leu Ala Lys Tyr Leu Cys Val 
     130                135                140
Leu Leu Ile Val Ala Gly Val Ala Leu Phe Met Tyr Lys Pro Lys Lys 
 145                150                155                160
Val Val Gly Ile Glu Glu His Thr Val Gly Tyr Gly Glu Leu Leu Leu 
                 165                170                175
Leu Leu Ser Leu Thr Leu Asp Gly Leu Thr Gly Val Ser Gln Asp His 
             180                185                190
Met Arg Ala His Tyr Gln Thr Gly Ser Asn His Met Met Leu Asn Ile 
         195                200                205
Asn Leu Trp Ser Thr Leu Leu Leu Gly Met Gly Ile Leu Phe Thr Gly 
     210                215                220
Glu Leu Trp Glu Phe Leu Ser Phe Ala Glu Arg Tyr Pro Ala Ile Ile 
 225                230                235                240
Tyr Asn Ile Leu Leu Phe Gly Leu Thr Ser Ala Leu Gly Gln Ser Phe 
                 245                250                255
Ile Phe Met Thr Val Val Tyr Phe Gly Pro Leu Thr Cys Ser Ile Ile 
             260                265                270
Thr Thr Thr Arg Lys Phe Phe Thr Ile Leu Ala Ser Val Ile Leu Phe 
         275                280                285
Ala Asn Pro Ile Ser Pro Met Gln Trp Val Gly Thr Val Leu Val Phe 
     290                295                300
Leu Gly Leu Gly Leu Asp Ala Lys Phe Gly Lys Gly Ala Lys Lys Thr 
 305                310                315                320
Ser His 
                 325



<210> 2262
<211> 1156
<212> DNA
<213> Rattus norvegicus
<308> D87991
<400> 2262

cctggagct  tcgccttcg  ctccggtac  gctacctgt  ctgaacgga  ctccggccg  60
ctcgtccct  cgtctcatg  ccgctagca  atccctggt  cccgaccgg  tgcgcctac  120
actctgctt  ttgggtgtc  ttgtctgct  cttctacta  gggatcctg  aggagaaga  180
aacaagagg  aagtatgga  aaggaccca  acaggagac  ttcaccttt  ccttaactt  240
ggttttcat  cagtgtgtg  tcaatgcta  gtttgccaa  atcttgatc  agttttttg  300
cactgccag  gtggatcgc  ctcggacct  gctctatgc  gcctgctct  tctcctatg  360
gggcgccat  gtctccagc  actcagcac  acagtttgt  aactatcca  ctcaggtcc  420
tggtaaatc  tgcaagcca  tcccagtta  gctcctcgg  gtgaccctc  tgaagaaga  480
gtacccatt  gccaagtac  tgtgtgtgt  gctaattgt  gctggcgtg  ctcttttca  540
gtataagcc  aagaaggtg  ttgggatag  agagcacac  gtcggcttt  gagagctcc  600
tctgctctt  tctctgacc  tggatggac  gacaggtgt  tcccaggac  atatgcggg  660
tcattacca  acaggttcc  atcacatga  gttgaacat  aacctttgg  ccacggtct  720
gctcggtgc  gggatcctg  ttactgggg  gctctggga  ttcttgagt  tcgccgaga  780
gtacccgac  atcatctat  acatcctgc  ctttggctt  accagtgcc  tgggtcaga  840
ctttatctt  atgacagtc  tgtacttcg  ccccctgac  tgctccatc  tcaccacga  900
tcggaagtt  ttcaccatc  tggcttctg  gatcctctt  gccaatccc  tcagctcca  960
gcagtgggt  ggcaccgtg  tggttttcc  gggtctggg  cttgatgcc  agtttggga  1020
aggaacaaa  aagacctcc  actaggaaa  gagaggctt  ctccactcc  gaaacactt  1080
aattattat  tccaacagt  acatcttgg  aaaatggac  cagtcacga  aagggactg  1140
gttccaatc  ttttat  1156



<210> 2263
<211> 322
<212> PRT
<213> Rattus norvegicus
<308> BAA13527
<400> 2263

Met Ala Ala Ser Arg Ser Leu Val Pro Asp Arg Leu Arg Leu Pro Leu 
  1               5                  10                  15
Cys Phe Leu Gly Val Phe Val Cys Tyr Phe Tyr Tyr Gly Ile Leu Gln 
             20                  25                  30
Glu Lys Ile Thr Arg Gly Lys Tyr Gly Glu Gly Pro Lys Gln Glu Thr 
         35                  40                  45
Phe Thr Phe Ala Leu Thr Leu Val Phe Ile Gln Cys Val Ile Asn Ala 
     50                  55                  60
Met Phe Ala Lys Ile Leu Ile Gln Phe Phe Asp Thr Ala Arg Val Asp 
 65                  70                  75                  80
Arg Thr Arg Thr Trp Leu Tyr Ala Ala Cys Ser Val Ser Tyr Val Gly 
                 85                  90                  95
Ala Met Val Ser Ser Asn Ser Ala Leu Gln Phe Val Asn Tyr Pro Thr 
             100                105                110
Gln Val Leu Gly Lys Ser Cys Lys Pro Ile Pro Val Met Leu Leu Gly 
         115                120                125
Val Thr Leu Leu Lys Lys Lys Tyr Pro Leu Ala Lys Tyr Leu Cys Val 
     130                135                140
Leu Leu Ile Val Ala Gly Val Ala Leu Phe Met Tyr Lys Pro Lys Lys 
 145                150                155                160
Val Val Gly Ile Glu Glu His Thr Val Gly Phe Gly Glu Leu Leu Leu 
                 165                170                175
Leu Leu Ser Leu Thr Leu Asp Gly Leu Thr Gly Val Ser Gln Asp His 
             180                185                190
Met Arg Ala His Tyr Gln Thr Gly Ser Asn His Met Met Leu Asn Ile 
         195                200                205
Asn Leu Trp Ser Thr Val Leu Leu Gly Ala Gly Ile Leu Phe Thr Gly 
     210                215                220
Glu Leu Trp Glu Phe Leu Ser Phe Ala Glu Arg Tyr Pro Thr Ile Ile 
 225                230                235                240
Tyr Asn Ile Leu Leu Phe Gly Leu Thr Ser Ala Leu Gly Gln Ser Phe 
                 245                250                255
Ile Phe Met Thr Val Val Tyr Phe Gly Pro Leu Thr Cys Ser Ile Ile 
             260                265                270
Thr Thr Thr Arg Lys Phe Phe Thr Ile Leu Ala Ser Val Ile Leu Phe 
         275                280                285
Ala Asn Pro Ile Ser Ser Met Gln Trp Val Gly Thr Val Leu Val Phe 
     290                295                300
Leu Gly Leu Gly Leu Asp Ala Lys Phe Gly Lys Gly Thr Lys Lys Thr 
 305                310                315                320
Ser His 
                 325



<210> 2264
<211> 1186
<212> DNA
<213> Homo sapiens
<308> NM_005827
<400> 2264

gatgtccgg  tggagctgt  gcctccgcc  ccgctgctg  cggtgccgg  tgtgagcgg  60
tctccagtc  gctcctctg  gcgtctcat  gcctctagc  gctccctgg  gcccgaccg  120
ctgcgcctg  cgctctgct  cctgggtgt  tttgtctgc  atttttact  tgggatcct  180
caggaaaag  taacaagag  aaagtatgg  gaaggagcc  agcaggaga  gttcacctt  240
gccttaact  tggtcttca  tcaatgtgt  atcaatgct  tgtttgcca  gatcttgat  300
cagtttttt  acactgcca  ggtggatcg  acccggagc  ggctctatg  tgcctgttc  360
atctcctat  tgggtgcca  ggtctccag  aattcagca  tacagtttg  caactaccc  420
actcaggtc  ttggtaaat  ctgcaagcc  atcccagtc  tgctccttg  ggtgaccct  480
ttgaagaag  agtacccgt  ggccaagta  ctgtgtgtg  tgttaattg  ggctggagt  540
gcccttttc  tgtacaaac  caagaaagt  gttgggata  aagaacaca  agtcggcta  600
ggagagcta  tcttgctat  atcgctgac  ctggatgga  tgactggtg  ttcccagga  660
cacatgcgg  ctcattacc  aacaggctc  aaccacatg  tgctgaaca  caacctttg  720
tcgacattg  tgctgggaa  gggaatcct  ttcactggg  agctctggg  gttcttgag  780
tttgctgaa  ggtaccctg  catcatcta  aacatcctg  tctttgggc  gaccagtgc  840
ctgggtcag  gcttcatct  tatgacggt  gtgtatttt  gtcccctga  ctgctccat  900
atcactaca  ctcgaaagt  cttcacaat  ttggcctct  tgatcctct  cgccaatcc  960
atcagcccc  tgcagtggg  gggcactgt  cttgtgttc  tgggtcttg  tcttgatgc  1020
aagtttggg  aaggagcta  gaagacatc  cactaggaa  agagagact  cctccacat  1080
aagaatatt  aagttatta  ctcaaacag  gacatctct  gggaaaatg  acttaatag  1140
aatatggga  tgagttcca  tctttttta  taaaataaa  tcaagc  1186



<210> 2265
<211> 322
<212> PRT
<213> Homo sapiens
<308> NP_005818
<400> 2265

Met Ala Ser Ser Ser Ser Leu Val Pro Asp Arg Leu Arg Leu Pro Leu 
  1               5                  10                  15
Cys Phe Leu Gly Val Phe Val Cys Tyr Phe Tyr Tyr Gly Ile Leu Gln 
             20                  25                  30
Glu Lys Ile Thr Arg Gly Lys Tyr Gly Glu Gly Ala Lys Gln Glu Thr 
         35                  40                  45
Phe Thr Phe Ala Leu Thr Leu Val Phe Ile Gln Cys Val Ile Asn Ala 
     50                  55                  60
Val Phe Ala Lys Ile Leu Ile Gln Phe Phe Asp Thr Ala Arg Val Asp 
 65                  70                  75                  80
Arg Thr Arg Ser Trp Leu Tyr Ala Ala Cys Ser Ile Ser Tyr Leu Gly 
                 85                  90                  95
Ala Met Val Ser Ser Asn Ser Ala Leu Gln Phe Val Asn Tyr Pro Thr 
             100                105                110
Gln Val Leu Gly Lys Ser Cys Lys Pro Ile Pro Val Met Leu Leu Gly 
         115                120                125
Val Thr Leu Leu Lys Lys Lys Tyr Pro Leu Ala Lys Tyr Leu Cys Val 
     130                135                140
Leu Leu Ile Val Ala Gly Val Ala Leu Phe Met Tyr Lys Pro Lys Lys 
 145                150                155                160
Val Val Gly Ile Glu Glu His Thr Val Gly Tyr Gly Glu Leu Leu Leu 
                 165                170                175
Leu Leu Ser Leu Thr Leu Asp Gly Leu Thr Gly Val Ser Gln Asp His 
             180                185                190
Met Arg Ala His Tyr Gln Thr Gly Ser Asn His Met Met Leu Asn Ile 
         195                200                205
Asn Leu Trp Ser Thr Leu Leu Leu Gly Met Gly Ile Leu Phe Thr Gly 
     210                215                220
Glu Leu Trp Glu Phe Leu Ser Phe Ala Glu Arg Tyr Pro Ala Ile Ile 
 225                230                235                240
Tyr Asn Ile Leu Leu Phe Gly Leu Thr Ser Ala Leu Gly Gln Ser Phe 
                 245                250                255
Ile Phe Met Thr Val Val Tyr Phe Gly Pro Leu Thr Cys Ser Ile Ile 
             260                265                270
Thr Thr Thr Arg Lys Phe Phe Thr Ile Leu Ala Ser Val Ile Leu Phe 
         275                280                285
Ala Asn Pro Ile Ser Pro Met Gln Trp Val Gly Thr Val Leu Val Phe 
     290                295                300
Leu Gly Leu Gly Leu Asp Ala Lys Phe Gly Lys Gly Ala Lys Lys Thr 
 305                310                315                320
Ser His 
                 325



<210> 2266
<211> 1156
<212> DNA
<213> Rattus norvegicus
<308> D87991
<400> 2266

cctggagct  tcgccttcg  ctccggtac  gctacctgt  ctgaacgga  ctccggccg  60
ctcgtccct  cgtctcatg  ccgctagca  atccctggt  cccgaccgg  tgcgcctac  120
actctgctt  ttgggtgtc  ttgtctgct  cttctacta  gggatcctg  aggagaaga  180
aacaagagg  aagtatgga  aaggaccca  acaggagac  ttcaccttt  ccttaactt  240
ggttttcat  cagtgtgtg  tcaatgcta  gtttgccaa  atcttgatc  agttttttg  300
cactgccag  gtggatcgc  ctcggacct  gctctatgc  gcctgctct  tctcctatg  360
gggcgccat  gtctccagc  actcagcac  acagtttgt  aactatcca  ctcaggtcc  420
tggtaaatc  tgcaagcca  tcccagtta  gctcctcgg  gtgaccctc  tgaagaaga  480
gtacccatt  gccaagtac  tgtgtgtgt  gctaattgt  gctggcgtg  ctcttttca  540
gtataagcc  aagaaggtg  ttgggatag  agagcacac  gtcggcttt  gagagctcc  600
tctgctctt  tctctgacc  tggatggac  gacaggtgt  tcccaggac  atatgcggg  660
tcattacca  acaggttcc  atcacatga  gttgaacat  aacctttgg  ccacggtct  720
gctcggtgc  gggatcctg  ttactgggg  gctctggga  ttcttgagt  tcgccgaga  780
gtacccgac  atcatctat  acatcctgc  ctttggctt  accagtgcc  tgggtcaga  840
ctttatctt  atgacagtc  tgtacttcg  ccccctgac  tgctccatc  tcaccacga  900
tcggaagtt  ttcaccatc  tggcttctg  gatcctctt  gccaatccc  tcagctcca  960
gcagtgggt  ggcaccgtg  tggttttcc  gggtctggg  cttgatgcc  agtttggga  1020
aggaacaaa  aagacctcc  actaggaaa  gagaggctt  ctccactcc  gaaacactt  1080
aattattat  tccaacagt  acatcttgg  aaaatggac  cagtcacga  aagggactg  1140
gttccaatc  ttttat  1156



<210> 2267
<211> 322
<212> PRT
<213> Rattus norvegicus
<308> BAA13527
<400> 2267

Met Ala Ala Ser Arg Ser Leu Val Pro Asp Arg Leu Arg Leu Pro Leu 
  1               5                  10                  15
Cys Phe Leu Gly Val Phe Val Cys Tyr Phe Tyr Tyr Gly Ile Leu Gln 
             20                  25                  30
Glu Lys Ile Thr Arg Gly Lys Tyr Gly Glu Gly Pro Lys Gln Glu Thr 
         35                  40                  45
Phe Thr Phe Ala Leu Thr Leu Val Phe Ile Gln Cys Val Ile Asn Ala 
     50                  55                  60
Met Phe Ala Lys Ile Leu Ile Gln Phe Phe Asp Thr Ala Arg Val Asp 
 65                  70                  75                  80
Arg Thr Arg Thr Trp Leu Tyr Ala Ala Cys Ser Val Ser Tyr Val Gly 
                 85                  90                  95
Ala Met Val Ser Ser Asn Ser Ala Leu Gln Phe Val Asn Tyr Pro Thr 
             100                105                110
Gln Val Leu Gly Lys Ser Cys Lys Pro Ile Pro Val Met Leu Leu Gly 
         115                120                125
Val Thr Leu Leu Lys Lys Lys Tyr Pro Leu Ala Lys Tyr Leu Cys Val 
     130                135                140
Leu Leu Ile Val Ala Gly Val Ala Leu Phe Met Tyr Lys Pro Lys Lys 
 145                150                155                160
Val Val Gly Ile Glu Glu His Thr Val Gly Phe Gly Glu Leu Leu Leu 
                 165                170                175
Leu Leu Ser Leu Thr Leu Asp Gly Leu Thr Gly Val Ser Gln Asp His 
             180                185                190
Met Arg Ala His Tyr Gln Thr Gly Ser Asn His Met Met Leu Asn Ile 
         195                200                205
Asn Leu Trp Ser Thr Val Leu Leu Gly Ala Gly Ile Leu Phe Thr Gly 
     210                215                220
Glu Leu Trp Glu Phe Leu Ser Phe Ala Glu Arg Tyr Pro Thr Ile Ile 
 225                230                235                240
Tyr Asn Ile Leu Leu Phe Gly Leu Thr Ser Ala Leu Gly Gln Ser Phe 
                 245                250                255
Ile Phe Met Thr Val Val Tyr Phe Gly Pro Leu Thr Cys Ser Ile Ile 
             260                265                270
Thr Thr Thr Arg Lys Phe Phe Thr Ile Leu Ala Ser Val Ile Leu Phe 
         275                280                285
Ala Asn Pro Ile Ser Ser Met Gln Trp Val Gly Thr Val Leu Val Phe 
     290                295                300
Leu Gly Leu Gly Leu Asp Ala Lys Phe Gly Lys Gly Thr Lys Lys Thr 
 305                310                315                320
Ser His 
                 325



<210> 2268
<211> 1186
<212> DNA
<213> Homo sapiens
<308> NM_005827
<400> 2268

gatgtccgg  tggagctgt  gcctccgcc  ccgctgctg  cggtgccgg  tgtgagcgg  60
tctccagtc  gctcctctg  gcgtctcat  gcctctagc  gctccctgg  gcccgaccg  120
ctgcgcctg  cgctctgct  cctgggtgt  tttgtctgc  atttttact  tgggatcct  180
caggaaaag  taacaagag  aaagtatgg  gaaggagcc  agcaggaga  gttcacctt  240
gccttaact  tggtcttca  tcaatgtgt  atcaatgct  tgtttgcca  gatcttgat  300
cagtttttt  acactgcca  ggtggatcg  acccggagc  ggctctatg  tgcctgttc  360
atctcctat  tgggtgcca  ggtctccag  aattcagca  tacagtttg  caactaccc  420
actcaggtc  ttggtaaat  ctgcaagcc  atcccagtc  tgctccttg  ggtgaccct  480
ttgaagaag  agtacccgt  ggccaagta  ctgtgtgtg  tgttaattg  ggctggagt  540
gcccttttc  tgtacaaac  caagaaagt  gttgggata  aagaacaca  agtcggcta  600
ggagagcta  tcttgctat  atcgctgac  ctggatgga  tgactggtg  ttcccagga  660
cacatgcgg  ctcattacc  aacaggctc  aaccacatg  tgctgaaca  caacctttg  720
tcgacattg  tgctgggaa  gggaatcct  ttcactggg  agctctggg  gttcttgag  780
tttgctgaa  ggtaccctg  catcatcta  aacatcctg  tctttgggc  gaccagtgc  840
ctgggtcag  gcttcatct  tatgacggt  gtgtatttt  gtcccctga  ctgctccat  900
atcactaca  ctcgaaagt  cttcacaat  ttggcctct  tgatcctct  cgccaatcc  960
atcagcccc  tgcagtggg  gggcactgt  cttgtgttc  tgggtcttg  tcttgatgc  1020
aagtttggg  aaggagcta  gaagacatc  cactaggaa  agagagact  cctccacat  1080
aagaatatt  aagttatta  ctcaaacag  gacatctct  gggaaaatg  acttaatag  1140
aatatggga  tgagttcca  tctttttta  taaaataaa  tcaagc  1186



<210> 2269
<211> 322
<212> PRT
<213> Homo sapiens
<308> NP_005818
<400> 2269

Met Ala Ser Ser Ser Ser Leu Val Pro Asp Arg Leu Arg Leu Pro Leu 
  1               5                  10                  15
Cys Phe Leu Gly Val Phe Val Cys Tyr Phe Tyr Tyr Gly Ile Leu Gln 
             20                  25                  30
Glu Lys Ile Thr Arg Gly Lys Tyr Gly Glu Gly Ala Lys Gln Glu Thr 
         35                  40                  45
Phe Thr Phe Ala Leu Thr Leu Val Phe Ile Gln Cys Val Ile Asn Ala 
     50                  55                  60
Val Phe Ala Lys Ile Leu Ile Gln Phe Phe Asp Thr Ala Arg Val Asp 
 65                  70                  75                  80
Arg Thr Arg Ser Trp Leu Tyr Ala Ala Cys Ser Ile Ser Tyr Leu Gly 
                 85                  90                  95
Ala Met Val Ser Ser Asn Ser Ala Leu Gln Phe Val Asn Tyr Pro Thr 
             100                105                110
Gln Val Leu Gly Lys Ser Cys Lys Pro Ile Pro Val Met Leu Leu Gly 
         115                120                125
Val Thr Leu Leu Lys Lys Lys Tyr Pro Leu Ala Lys Tyr Leu Cys Val 
     130                135                140
Leu Leu Ile Val Ala Gly Val Ala Leu Phe Met Tyr Lys Pro Lys Lys 
 145                150                155                160
Val Val Gly Ile Glu Glu His Thr Val Gly Tyr Gly Glu Leu Leu Leu 
                 165                170                175
Leu Leu Ser Leu Thr Leu Asp Gly Leu Thr Gly Val Ser Gln Asp His 
             180                185                190
Met Arg Ala His Tyr Gln Thr Gly Ser Asn His Met Met Leu Asn Ile 
         195                200                205
Asn Leu Trp Ser Thr Leu Leu Leu Gly Met Gly Ile Leu Phe Thr Gly 
     210                215                220
Glu Leu Trp Glu Phe Leu Ser Phe Ala Glu Arg Tyr Pro Ala Ile Ile 
 225                230                235                240
Tyr Asn Ile Leu Leu Phe Gly Leu Thr Ser Ala Leu Gly Gln Ser Phe 
                 245                250                255
Ile Phe Met Thr Val Val Tyr Phe Gly Pro Leu Thr Cys Ser Ile Ile 
             260                265                270
Thr Thr Thr Arg Lys Phe Phe Thr Ile Leu Ala Ser Val Ile Leu Phe 
         275                280                285
Ala Asn Pro Ile Ser Pro Met Gln Trp Val Gly Thr Val Leu Val Phe 
     290                295                300
Leu Gly Leu Gly Leu Asp Ala Lys Phe Gly Lys Gly Ala Lys Lys Thr 
 305                310                315                320
Ser His 
                 325



<210> 2270
<211> 2908
<212> DNA
<213> Rattus norvegicus
<308> D88250
<400> 2270

ggaggtatc  aggaagaga  aacagggag  tggggcgga  gttcctcgc  gagcctctg  60
agccgcagg  gcttcacgg  atgaccaga  gcaggagag  aggctgacc  acttgttcc  120
atcagctcc  gaaggtgac  ctgagccct  ggtggcccc  cactgccaa  gcagtcacc  180
gtatttgtc  gataaagac  gccagcccg  ctgcccttt  cctccaagt  agagatcca  240
agagccatg  gcaaatcgc  agagatgtg  tgctttgtc  tcttttctc  tttggcatc  300
ttttctgct  agcctacca  gtatgggga  atcctgtcc  ctaattatc  ccaggcgta  360
cccaatgag  tcgtgaaaa  ttgggacat  gaagtccca  aggggtttg  gattcacct  420
tacttcacc  atctggaca  ggagctgtc  gagaactgt  catacgact  agtgcagat  480
atctcagga  gtatcgagg  agagagact  tgtggccag  ggtccagca  gagtcccaa  540
tcccccact  tagaagagt  tcaattccc  tacaatagg  tccaggtgg  ctttacgtc  600
gacttctcc  acgaggaac  gtttactgg  tttgcagcg  attactcag  cgtagatgt  660
aatgaatgc  cagacttta  agatgtccc  tgcagccac  tctgcaata  cttcattgg  720
ggatacttc  gctcctgcc  cccagaata  ttcctccac  atgacatga  gacttgtgg  780
gtcaactgt  gtggggatg  attcactgc  ttgattggg  agatcgcaa  tcccaatta  840
cccaaccca  acccggaga  ctcaaggtg  gaataccag  ttcggctgc  ggagggctt  900
cgactggtg  tgactatcc  gagagaaga  tttgatgtg  aaccagcgg  ctcagaggg  960
aactgccac  acagtttga  ttttgctgc  aaaaaccaa  agtttggtc  ttactgtgg  1020
aatggattc  ctggacctc  aactattaa  acccagagc  atactcttg  tattgtctt  1080
caaactgac  taacggggc  aaataaagg  tggaagctt  gttaccatg  agatcccat  1140
ccctgtccc  aagaaatca  tgctaattc  atctgggag  ccgaaaagg  aaaatacgt  1200
ttcaaagat  tcgtgaaga  aacctgtgt  gatggattc  aagttgtgg  gggaaatgt  1260
ggctcaaca  cattctatt  cacttgtca  agcaacgga  agtggagca  ttccaggct  1320
gagtgtcaa  ctgtggact  tggtgttcc  gaacccatt  agaatggta  agttgaaga  1380
ccagaagac  ctgtattcg  ctccgtcat  cactacacg  gcgaagagc  atattacta  1440
atggaacag  aagaaggcg  agagtatca  tgtgctgct  atgggagct  ggtgaatga  1500
cagctgggt  tcgagcttc  aaaatgtat  ccagtctgt  gagtaccca  cgagccctt  1560
aaagtacag  agaggatat  tggaggata  tctacaaag  ttcaaagtt  tccttggca  1620
gtctacttt  agtcccccc  aggtggcgg  gctcttatc  atgagtact  ggtgctgac  1680
gccgctcac  ttgtggagg  aaactctga  ccagtgatg  atgtcgggt  cacacttct  1740
aaaatagag  ggttgagaa  tgcccagag  ctcatcact  aacgtgtga  tattcatcc  1800
agctggaaa  aagaggacg  cctgaatac  cggacaaat  ttgacaatg  cattgccct  1860
gtgcagctc  aagaccctg  gaaaatggg  cccactgtt  cccccatct  cctgccaga  1920
accttctca  actacaacc  ctcagaggt  gacctgggg  tgatctctg  gtggggccg  1980
acagagatt  gaaccaatg  tattcaact  agaggggcg  agttaccca  aacatcttt  2040
gaaaagtgc  agcaggtga  agtggaaaa  ccgaaagcg  ggtcaaacg  ctatgtttt  2100
actgacaac  tgatctgtg  tggggaaaa  ggtgtggac  gctgtgaag  tgacagcgg  2160
ggggctttt  ctctgccgg  ccccaatgt  aaggacccc  aattctatg  ggctggcct  2220
gtgtcctgg  ggaaaaagt  tgggaccta  gggatctac  caaaggtaa  gaactacgt  2280
gactggatc  tgaaaacta  gcaggagaa  agtgggccc  agaaggact  atccgtagt  2340
acaacaccc  tccaggact  gcaaggtca  ttttctcag  tcctgggac  gtcccatta  2400
ttcaaaatg  tggagagag  gtgtgggag  atggttaac  ttgaacatg  ttgtcaaga  2460
gcctgcttg  aggcagagt  gatcactga  ccgtgttgg  tattcagtt  ctattgcta  2520
caacatgcg  aagcctttc  gtcttgctt  atcccacag  gatatctta  acgatttcc  2580
cctcattta  cccgcttga  atccttatt  cttacagta  agcatgttt  caatctggt  2640
ctggctgct  gagagccca  aaggagagg  aaatttgag  gtattttgt  atggaattc  2700
ggcatcgac  ggttgtctg  aacactatg  agtcaggga  cacagcctt  tttctaagt  2760
agatttacc  aatagctgg  agtcagaat  gactacctt  gctttcctt  gtgagttgt  2820
tcaatatgt  ccctagaaa  tagttttct  ataatcctc  tttgtatca  acaatgtaa  2880
gacttaata  aagagaaat  gaacattg  2908



<210> 2271
<211> 695
<212> PRT
<213> Rattus norvegicus
<308> D88250
<400> 2271

Met Gly Lys Ser Pro Glu Met Trp Cys Phe Val Phe Phe Ser Leu Leu 
  1               5                  10                  15
Ala Ser Phe Ser Ala Glu Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro 
             20                  25                  30
Asn Tyr Pro Gln Ala Tyr Pro Asn Glu Val Val Lys Thr Trp Asp Ile 
         35                  40                  45
Glu Val Pro Glu Gly Phe Gly Ile His Leu Tyr Phe Thr His Leu Asp 
     50                  55                  60
Met Glu Leu Ser Glu Asn Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser 
 65                  70                  75                  80
Gly Gly Ile Glu Glu Glu Arg Leu Cys Gly Gln Arg Ser Ser Lys Ser 
                 85                  90                  95
Pro Asn Ser Pro Thr Val Glu Glu Phe Gln Phe Pro Tyr Asn Arg Leu 
             100                105                110
Gln Val Val Phe Thr Ser Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly 
         115                120                125
Phe Ala Ala Tyr Tyr Ser Ala Val Asp Val Asn Glu Cys Thr Asp Phe 
     130                135                140
Thr Asp Val Pro Cys Ser His Phe Cys Asn Asn Phe Ile Gly Gly Tyr 
 145                150                155                160
Phe Cys Ser Cys Pro Pro Glu Tyr Phe Leu His Asp Asp Met Arg Thr 
                 165                170                175
Cys Gly Val Asn Cys Ser Gly Asp Val Phe Thr Ala Leu Ile Gly Glu 
             180                185                190
Ile Ala Ser Pro Asn Tyr Pro Asn Pro Tyr Pro Glu Asn Ser Arg Cys 
         195                200                205
Glu Tyr Gln Ile Arg Leu Gln Glu Gly Phe Arg Leu Val Leu Thr Ile 
     210                215                220
Arg Arg Glu Asp Phe Asp Val Glu Pro Ala Asp Ser Glu Gly Asn Cys 
 225                230                235                240
His Asp Ser Leu Thr Phe Ala Ala Lys Asn Gln Gln Phe Gly Pro Tyr 
                 245                250                255
Cys Gly Asn Gly Phe Pro Gly Pro Leu Thr Ile Lys Thr Gln Ser Asn 
             260                265                270
Thr Leu Asp Ile Val Phe Gln Thr Asp Leu Thr Gly Gln Asn Lys Gly 
         275                280                285
Trp Lys Leu Arg Tyr His Gly Asp Pro Ile Pro Cys Pro Lys Glu Ile 
     290                295                300
Ser Ala Asn Ser Ile Trp Glu Pro Glu Lys Ala Lys Tyr Val Phe Lys 
 305                310                315                320
Asp Val Val Lys Ile Thr Cys Val Asp Gly Phe Glu Val Val Glu Gly 
                 325                330                335
Asn Val Gly Ser Thr Ser Phe Tyr Ser Thr Cys Gln Ser Asn Gly Gln 
             340                345                350
Trp Ser Asn Ser Arg Leu Glu Cys Gln Pro Val Asp Cys Gly Val Pro 
         355                360                365
Glu Pro Ile Glu Asn Gly Lys Val Glu Asp Pro Glu Asp Thr Val Phe 
     370                375                380
Gly Ser Val Ile His Tyr Thr Cys Glu Glu Pro Tyr Tyr Tyr Met Glu 
 385                390                395                400
Gln Glu Glu Gly Gly Glu Tyr His Cys Ala Ala Asn Gly Ser Trp Val 
                 405                410                415
Asn Asp Gln Leu Gly Val Glu Leu Pro Lys Cys Ile Pro Val Cys Gly 
             420                425                430
Val Pro Thr Glu Pro Phe Lys Val Gln Gln Arg Ile Phe Gly Gly Tyr 
         435                440                445
Ser Thr Lys Ile Gln Ser Phe Pro Trp Gln Val Tyr Phe Glu Ser Pro 
     450                455                460
Arg Gly Gly Gly Ala Leu Ile Asp Glu Tyr Trp Val Leu Thr Ala Ala 
 465                470                475                480
His Val Val Glu Gly Asn Ser Asp Pro Val Met Tyr Val Gly Ser Thr 
                 485                490                495
Leu Leu Lys Ile Glu Arg Leu Arg Asn Ala Gln Arg Leu Ile Thr Glu 
             500                505                510
Arg Val Ile Ile His Pro Ser Trp Lys Gln Glu Asp Asp Leu Asn Thr 
         515                520                525
Arg Thr Asn Phe Asp Asn Asp Ile Ala Leu Val Gln Leu Lys Asp Pro 
     530                535                540
Val Lys Met Gly Pro Thr Val Ala Pro Ile Cys Leu Pro Glu Thr Phe 
 545                550                555                560
Ser Asp Tyr Asn Pro Ser Glu Val Asp Leu Gly Leu Ile Ser Gly Trp 
                 565                570                575
Gly Arg Thr Glu Ile Arg Thr Asn Val Ile Gln Leu Arg Gly Ala Lys 
             580                585                590
Leu Pro Ile Thr Ser Leu Glu Lys Cys Gln Gln Val Lys Val Glu Asn 
         595                600                605
Pro Lys Ala Arg Ser Asn Asp Tyr Val Phe Thr Asp Asn Met Ile Cys 
     610                615                620
Ala Gly Glu Lys Gly Val Asp Ser Cys Glu Gly Asp Ser Gly Gly Ala 
 625                630                635                640
Phe Ala Leu Pro Val Pro Asn Val Lys Asp Pro Lys Phe Tyr Val Ala 
                 645                650                655
Gly Leu Val Ser Trp Gly Lys Lys Cys Gly Thr Tyr Gly Ile Tyr Thr 
             660                665                670
Lys Val Lys Asn Tyr Val Asp Trp Ile Leu Lys Thr Met Gln Glu Asn 
         675                680                685
Ser Gly Pro Lys Lys Asp Ter 
     690                695



<210> 2272
<211> 2647
<212> DNA
<213> Homo sapiens
<308> J04080
<400> 2272

gggccggag  tcctgcaga  ggagcgtca  ggccctgtg  tgctgtccc  gggggccag  60
ggggttgcc  agcatgccc  ctggcagga  agagggaac  gacccactt  ctcctacca  120
cttctgaag  ctccaaagt  cggagtgca  aaagccagg  ccaagagac  ggcagctca  180
cagggtgga  aaatcgcca  agatgtggt  cattgtcct  ttttcactt  tggcatggg  240
ttatgctga  cctaccatg  atggggaga  cctgtcccc  aactatcct  aggcatatc  300
cagtgaggt  gagaaatct  gggacatag  agttcctga  gggtatggg  ttcacctct  360
cttcaccca  ctggacatt  agctgtcag  gaactgtgc  tatgactca  tgcagataa  420
ctcaggaga  actgaagaa  ggaggctct  tggacagag  agcagtaac  atccccact  480
tccaattgt  gaagagttc  aagtcccat  caacaaact  caggtgatc  ttaagtcag  540
cttttccaa  gaagagcgt  ttacggggt  tgctgcata  tatgttgcc  cagacataa  600
tgaatgcac  gattttgta  atgtccctt  tagccactt  tgcaacaat  tcattggtg  660
ttacttctg  tcctgcccc  cggaatatt  cctccatga  gacatgaag  attgcggag  720
taattgcag  ggggatgta  tcactgcac  gattgggga  attgcaagt  ccaattatc  780
caaaccata  ccagagaac  caaggtgtg  ataccagat  cggttggag  aagggttcc  840
agtggtggt  accttgcgg  gagaagatt  tgatgtgga  gcagctgac  cagcgggaa  900
ctgccttga  agtttagtt  ttgttgcag  agatcggca  tttggtcct  actgtggtc  960
tggattccc  gggcctcta  atattgaaa  caagagtaa  gctcttgat  tcatcttcc  1020
aactgatct  acagggcaa  aaaagggct  gaaacttcg  tatcatgga  atccaatgc  1080
ctgccctaa  gaagacact  ccaattctg  ttgggagcc  gcgaaggca  aatatgtct  1140
tagagatgt  gtgcagata  cctgtctgg  tgggtttga  gttgtggag  gacgtgttg  1200
tgcaacatc  ttctattcg  cttgtcaaa  caatggaaa  tggagtaat  ccaaactga  1260
atgtcaacc  gtggactgt  gcattcctg  atccattga  aatggtaaa  ttgaagacc  1320
agagagcac  ttgtttggt  ctgtcatcc  ctacacttg  gaggagcca  attactaca  1380
ggaaaatgg  ggaggtggg  agtatcact  tgctggtaa  gggagctgg  tgaatgagg  1440
gctgggccc  gagctgccg  aatgtgttc  agtctgtgg  gtccccaga  aaccctttg  1500
agaaaaaca  aggataatt  gaggatccg  tgcagatat  aaaaacttc  cctggcaag  1560
cttctttga  aacccatgg  ctggtggag  gctcattaa  gagtactgg  tgctgacgg  1620
tgctcatgt  gtggaggga  acagggagc  aacaatgta  gttgggtcc  cctcagtgc  1680
gacctcacg  ctggcaaaa  ccaagatgc  cactcctga  catgtgttt  ttcatccgg  1740
atggaagct  ctggaagtc  cagaaggac  aaccaattt  gataatgac  ttgcactgg  1800
gcggctgaa  gacccagtg  aaatgggac  caccgtctc  cccatctgc  taccaggca  1860
ctcttccga  tacaacctc  tggatgggg  cctgggact  atctcaggc  ggggccgaa  1920
agagaagag  gatcgtgct  ttcgcctca  ggcggcaag  ttacctgta  ctcctttaa  1980
aaaatgcaa  gaagtgaaa  tggagaaac  cacagcaga  gcagaggcc  atgttttca  2040
tcctaacat  atctgtgct  gaggagaga  gggcatgga  agctgtaaa  gggacagtg  2100
tggggcctt  gctgtacag  atcccaatg  caagaccaa  ttctacgca  ctggcctgg  2160
gtcctgggg  ccccagtgt  ggacctatg  gctctacac  cgggtaaag  actatgttg  2220
ctggataat  aagactatg  aggaaaata  caccccccg  gaggactaa  ccagataca  2280
cccaccagc  tctccaagg  tggtgacca  tgcattacc  tctgttcct  atgatattc  2340
cattatttc  tcatgactg  aagaagaca  gagcgaatg  tttaaatag  acttgattg  2400
tgagacgcc  tgctagagg  agagtttga  catagaatt  tgctggtca  acatttgtg  2460
tctgactcc  tggggtcct  tccccggag  acctattgt  gataacact  tgggtgggg  2520
actcctttc  tgcactatt  cacagggat  ccttaattc  ttgtttcct  tttacctgt  2580
caaaattcc  tttacttga  cattctcag  atccactgt  tatgtacaa  aaaggatgt  2640
tataagc  2647



<210> 2273
<211> 688
<212> PRT
<213> Homo sapiens
<308> Q9UCV3
<400> 2273

Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala Glu 
  1               5                  10                  15
Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala Tyr 
             20                  25                  30
Pro Ser Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly Tyr 
         35                  40                  45
Gly Ile His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu Ser Glu Asn 
     50                  55                  60
Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser Gly Asp Thr Glu Glu Gly 
 65                  70                  75                  80
Arg Leu Cys Gly Gln Arg Ser Ser Asn Asn Pro His Ser Pro Ile Val 
                 85                  90                  95
Glu Glu Phe Gln Val Pro Tyr Asn Lys Leu Gln Val Ile Phe Lys Ser 
             100                105                110
Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly Phe Ala Ala Tyr Tyr Val 
         115                120                125
Ala Thr Asp Ile Asn Glu Cys Thr Asp Phe Val Asp Val Pro Cys Ser 
     130                135                140
His Phe Cys Asn Asn Phe Ile Gly Gly Tyr Phe Cys Ser Cys Pro Pro 
 145                150                155                160
Glu Tyr Phe Leu His Asp Asp Met Lys Asn Cys Gly Val Asn Cys Ser 
                 165                170                175
Gly Asp Val Phe Thr Ala Leu Ile Gly Glu Ile Ala Ser Pro Asn Tyr 
             180                185                190
Pro Lys Pro Tyr Pro Glu Asn Ser Arg Cys Glu Tyr Gln Ile Arg Leu 
         195                200                205
Glu Lys Gly Phe Gln Val Val Val Thr Leu Arg Arg Glu Asp Phe Asp 
     210                215                220
Val Glu Ala Ala Asp Ser Ala Gly Asn Cys Leu Asp Ser Leu Val Phe 
 225                230                235                240
Val Ala Gly Asp Arg Gln Phe Gly Pro Tyr Cys Gly His Gly Phe Pro 
                 245                250                255
Gly Pro Leu Asn Ile Glu Thr Lys Ser Asn Ala Leu Asp Ile Ile Phe 
             260                265                270
Gln Thr Asp Leu Thr Gly Gln Lys Lys Gly Trp Lys Leu Arg Tyr His 
         275                280                285
Gly Asp Pro Met Pro Cys Pro Lys Glu Asp Thr Pro Asn Ser Val Trp 
     290                295                300
Glu Pro Ala Lys Ala Lys Tyr Val Phe Arg Asp Val Val Gln Ile Thr 
 305                310                315                320
Cys Leu Asp Gly Phe Glu Val Val Glu Gly Arg Val Gly Ala Thr Ser 
                 325                330                335
Phe Tyr Ser Thr Cys Gln Ser Asn Gly Lys Trp Ser Asn Ser Lys Leu 
             340                345                350
Lys Cys Gln Pro Val Asp Cys Gly Ile Pro Glu Ser Ile Glu Asn Gly 
         355                360                365
Lys Val Glu Asp Pro Glu Ser Thr Leu Phe Gly Ser Val Ile Arg Tyr 
     370                375                380
Thr Cys Glu Glu Pro Tyr Tyr Tyr Met Glu Asn Gly Gly Gly Gly Glu 
 385                390                395                400
Tyr His Cys Ala Gly Asn Gly Ser Trp Val Asn Glu Val Leu Gly Pro 
                 405                410                415
Glu Leu Pro Lys Cys Val Pro Val Cys Gly Val Pro Arg Glu Pro Phe 
             420                425                430
Glu Glu Lys Gln Arg Ile Ile Gly Gly Ser Asp Ala Asp Ile Lys Asn 
         435                440                445
Phe Pro Trp Gln Val Phe Phe Asp Asn Pro Trp Ala Gly Gly Ala Leu 
     450                455                460
Ile Asn Glu Tyr Trp Val Leu Thr Ala Ala His Val Val Glu Gly Asn 
 465                470                475                480
Arg Glu Pro Thr Met Tyr Val Gly Ser Thr Ser Val Gln Thr Ser Arg 
                 485                490                495
Leu Ala Lys Ser Lys Met Leu Thr Pro Glu His Val Phe Ile His Pro 
             500                505                510
Gly Trp Lys Leu Leu Glu Val Pro Glu Gly Arg Thr Asn Phe Asp Asn 
         515                520                525
Asp Ile Ala Leu Val Arg Leu Lys Asp Pro Val Lys Met Gly Pro Thr 
     530                535                540
Val Ser Pro Ile Cys Leu Pro Gly Thr Ser Ser Asp Tyr Asn Leu Met 
 545                550                555                560
Asp Gly Asp Leu Gly Leu Ile Ser Gly Trp Gly Arg Thr Glu Lys Arg 
                 565                570                575
Asp Arg Ala Val Arg Leu Lys Ala Ala Arg Leu Pro Val Ala Pro Leu 
             580                585                590
Arg Lys Cys Lys Glu Val Lys Val Glu Lys Pro Thr Ala Asp Ala Glu 
         595                600                605
Ala Tyr Val Phe Thr Pro Asn Met Ile Cys Ala Gly Gly Glu Lys Gly 
     610                615                620
Met Asp Ser Cys Lys Gly Asp Ser Gly Gly Ala Phe Ala Val Gln Asp 
 625                630                635                640
Pro Asn Asp Lys Thr Lys Phe Tyr Ala Ala Gly Leu Val Ser Trp Gly 
                 645                650                655
Pro Gln Cys Gly Thr Tyr Gly Leu Tyr Thr Arg Val Lys Asn Tyr Val 
             660                665                670
Asp Trp Ile Met Lys Thr Met Gln Glu Asn Ser Thr Pro Arg Glu Asp 
         675                680                685



<210> 2274
<211> 2908
<212> DNA
<213> Rattus norvegicus
<308> D88250
<400> 2274

ggaggtatc  aggaagaga  aacagggag  tggggcgga  gttcctcgc  gagcctctg  60
agccgcagg  gcttcacgg  atgaccaga  gcaggagag  aggctgacc  acttgttcc  120
atcagctcc  gaaggtgac  ctgagccct  ggtggcccc  cactgccaa  gcagtcacc  180
gtatttgtc  gataaagac  gccagcccg  ctgcccttt  cctccaagt  agagatcca  240
agagccatg  gcaaatcgc  agagatgtg  tgctttgtc  tcttttctc  tttggcatc  300
ttttctgct  agcctacca  gtatgggga  atcctgtcc  ctaattatc  ccaggcgta  360
cccaatgag  tcgtgaaaa  ttgggacat  gaagtccca  aggggtttg  gattcacct  420
tacttcacc  atctggaca  ggagctgtc  gagaactgt  catacgact  agtgcagat  480
atctcagga  gtatcgagg  agagagact  tgtggccag  ggtccagca  gagtcccaa  540
tcccccact  tagaagagt  tcaattccc  tacaatagg  tccaggtgg  ctttacgtc  600
gacttctcc  acgaggaac  gtttactgg  tttgcagcg  attactcag  cgtagatgt  660
aatgaatgc  cagacttta  agatgtccc  tgcagccac  tctgcaata  cttcattgg  720
ggatacttc  gctcctgcc  cccagaata  ttcctccac  atgacatga  gacttgtgg  780
gtcaactgt  gtggggatg  attcactgc  ttgattggg  agatcgcaa  tcccaatta  840
cccaaccca  acccggaga  ctcaaggtg  gaataccag  ttcggctgc  ggagggctt  900
cgactggtg  tgactatcc  gagagaaga  tttgatgtg  aaccagcgg  ctcagaggg  960
aactgccac  acagtttga  ttttgctgc  aaaaaccaa  agtttggtc  ttactgtgg  1020
aatggattc  ctggacctc  aactattaa  acccagagc  atactcttg  tattgtctt  1080
caaactgac  taacggggc  aaataaagg  tggaagctt  gttaccatg  agatcccat  1140
ccctgtccc  aagaaatca  tgctaattc  atctgggag  ccgaaaagg  aaaatacgt  1200
ttcaaagat  tcgtgaaga  aacctgtgt  gatggattc  aagttgtgg  gggaaatgt  1260
ggctcaaca  cattctatt  cacttgtca  agcaacgga  agtggagca  ttccaggct  1320
gagtgtcaa  ctgtggact  tggtgttcc  gaacccatt  agaatggta  agttgaaga  1380
ccagaagac  ctgtattcg  ctccgtcat  cactacacg  gcgaagagc  atattacta  1440
atggaacag  aagaaggcg  agagtatca  tgtgctgct  atgggagct  ggtgaatga  1500
cagctgggt  tcgagcttc  aaaatgtat  ccagtctgt  gagtaccca  cgagccctt  1560
aaagtacag  agaggatat  tggaggata  tctacaaag  ttcaaagtt  tccttggca  1620
gtctacttt  agtcccccc  aggtggcgg  gctcttatc  atgagtact  ggtgctgac  1680
gccgctcac  ttgtggagg  aaactctga  ccagtgatg  atgtcgggt  cacacttct  1740
aaaatagag  ggttgagaa  tgcccagag  ctcatcact  aacgtgtga  tattcatcc  1800
agctggaaa  aagaggacg  cctgaatac  cggacaaat  ttgacaatg  cattgccct  1860
gtgcagctc  aagaccctg  gaaaatggg  cccactgtt  cccccatct  cctgccaga  1920
accttctca  actacaacc  ctcagaggt  gacctgggg  tgatctctg  gtggggccg  1980
acagagatt  gaaccaatg  tattcaact  agaggggcg  agttaccca  aacatcttt  2040
gaaaagtgc  agcaggtga  agtggaaaa  ccgaaagcg  ggtcaaacg  ctatgtttt  2100
actgacaac  tgatctgtg  tggggaaaa  ggtgtggac  gctgtgaag  tgacagcgg  2160
ggggctttt  ctctgccgg  ccccaatgt  aaggacccc  aattctatg  ggctggcct  2220
gtgtcctgg  ggaaaaagt  tgggaccta  gggatctac  caaaggtaa  gaactacgt  2280
gactggatc  tgaaaacta  gcaggagaa  agtgggccc  agaaggact  atccgtagt  2340
acaacaccc  tccaggact  gcaaggtca  ttttctcag  tcctgggac  gtcccatta  2400
ttcaaaatg  tggagagag  gtgtgggag  atggttaac  ttgaacatg  ttgtcaaga  2460
gcctgcttg  aggcagagt  gatcactga  ccgtgttgg  tattcagtt  ctattgcta  2520
caacatgcg  aagcctttc  gtcttgctt  atcccacag  gatatctta  acgatttcc  2580
cctcattta  cccgcttga  atccttatt  cttacagta  agcatgttt  caatctggt  2640
ctggctgct  gagagccca  aaggagagg  aaatttgag  gtattttgt  atggaattc  2700
ggcatcgac  ggttgtctg  aacactatg  agtcaggga  cacagcctt  tttctaagt  2760
agatttacc  aatagctgg  agtcagaat  gactacctt  gctttcctt  gtgagttgt  2820
tcaatatgt  ccctagaaa  tagttttct  ataatcctc  tttgtatca  acaatgtaa  2880
gacttaata  aagagaaat  gaacattg  2908



<210> 2275
<211> 694
<212> PRT
<213> Rattus norvegicus
<308> BAA25797
<400> 2275

Met Gly Lys Ser Pro Glu Met Trp Cys Phe Val Phe Phe Ser Leu Leu 
  1               5                  10                  15
Ala Ser Phe Ser Ala Glu Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro 
             20                  25                  30
Asn Tyr Pro Gln Ala Tyr Pro Asn Glu Val Val Lys Thr Trp Asp Ile 
         35                  40                  45
Glu Val Pro Glu Gly Phe Gly Ile His Leu Tyr Phe Thr His Leu Asp 
     50                  55                  60
Met Glu Leu Ser Glu Asn Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser 
 65                  70                  75                  80
Gly Gly Ile Glu Glu Glu Arg Leu Cys Gly Gln Arg Ser Ser Lys Ser 
                 85                  90                  95
Pro Asn Ser Pro Thr Val Glu Glu Phe Gln Phe Pro Tyr Asn Arg Leu 
             100                105                110
Gln Val Val Phe Thr Ser Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly 
         115                120                125
Phe Ala Ala Tyr Tyr Ser Ala Val Asp Val Asn Glu Cys Thr Asp Phe 
     130                135                140
Thr Asp Val Pro Cys Ser His Phe Cys Asn Asn Phe Ile Gly Gly Tyr 
 145                150                155                160
Phe Cys Ser Cys Pro Pro Glu Tyr Phe Leu His Asp Asp Met Arg Thr 
                 165                170                175
Cys Gly Val Asn Cys Ser Gly Asp Val Phe Thr Ala Leu Ile Gly Glu 
             180                185                190
Ile Ala Ser Pro Asn Tyr Pro Asn Pro Tyr Pro Glu Asn Ser Arg Cys 
         195                200                205
Glu Tyr Gln Ile Arg Leu Gln Glu Gly Phe Arg Leu Val Leu Thr Ile 
     210                215                220
Arg Arg Glu Asp Phe Asp Val Glu Pro Ala Asp Ser Glu Gly Asn Cys 
 225                230                235                240
His Asp Ser Leu Thr Phe Ala Ala Lys Asn Gln Gln Phe Gly Pro Tyr 
                 245                250                255
Cys Gly Asn Gly Phe Pro Gly Pro Leu Thr Ile Lys Thr Gln Ser Asn 
             260                265                270
Thr Leu Asp Ile Val Phe Gln Thr Asp Leu Thr Gly Gln Asn Lys Gly 
         275                280                285
Trp Lys Leu Arg Tyr His Gly Asp Pro Ile Pro Cys Pro Lys Glu Ile 
     290                295                300
Ser Ala Asn Ser Ile Trp Glu Pro Glu Lys Ala Lys Tyr Val Phe Lys 
 305                310                315                320
Asp Val Val Lys Ile Thr Cys Val Asp Gly Phe Glu Val Val Glu Gly 
                 325                330                335
Asn Val Gly Ser Thr Ser Phe Tyr Ser Thr Cys Gln Ser Asn Gly Gln 
             340                345                350
Trp Ser Asn Ser Arg Leu Glu Cys Gln Pro Val Asp Cys Gly Val Pro 
         355                360                365
Glu Pro Ile Glu Asn Gly Lys Val Glu Asp Pro Glu Asp Thr Val Phe 
     370                375                380
Gly Ser Val Ile His Tyr Thr Cys Glu Glu Pro Tyr Tyr Tyr Met Glu 
 385                390                395                400
Gln Glu Glu Gly Gly Glu Tyr His Cys Ala Ala Asn Gly Ser Trp Val 
                 405                410                415
Asn Asp Gln Leu Gly Val Glu Leu Pro Lys Cys Ile Pro Val Cys Gly 
             420                425                430
Val Pro Thr Glu Pro Phe Lys Val Gln Gln Arg Ile Phe Gly Gly Tyr 
         435                440                445
Ser Thr Lys Ile Gln Ser Phe Pro Trp Gln Val Tyr Phe Glu Ser Pro 
     450                455                460
Arg Gly Gly Gly Ala Leu Ile Asp Glu Tyr Trp Val Leu Thr Ala Ala 
 465                470                475                480
His Val Val Glu Gly Asn Ser Asp Pro Val Met Tyr Val Gly Ser Thr 
                 485                490                495
Leu Leu Lys Ile Glu Arg Leu Arg Asn Ala Gln Arg Leu Ile Thr Glu 
             500                505                510
Arg Val Ile Ile His Pro Ser Trp Lys Gln Glu Asp Asp Leu Asn Thr 
         515                520                525
Arg Thr Asn Phe Asp Asn Asp Ile Ala Leu Val Gln Leu Lys Asp Pro 
     530                535                540
Val Lys Met Gly Pro Thr Val Ala Pro Ile Cys Leu Pro Glu Thr Phe 
 545                550                555                560
Ser Asp Tyr Asn Pro Ser Glu Val Asp Leu Gly Leu Ile Ser Gly Trp 
                 565                570                575
Gly Arg Thr Glu Ile Arg Thr Asn Val Ile Gln Leu Arg Gly Ala Lys 
             580                585                590
Leu Pro Ile Thr Ser Leu Glu Lys Cys Gln Gln Val Lys Val Glu Asn 
         595                600                605
Pro Lys Ala Arg Ser Asn Asp Tyr Val Phe Thr Asp Asn Met Ile Cys 
     610                615                620
Ala Gly Glu Lys Gly Val Asp Ser Cys Glu Gly Asp Ser Gly Gly Ala 
 625                630                635                640
Phe Ala Leu Pro Val Pro Asn Val Lys Asp Pro Lys Phe Tyr Val Ala 
                 645                650                655
Gly Leu Val Ser Trp Gly Lys Lys Cys Gly Thr Tyr Gly Ile Tyr Thr 
             660                665                670
Lys Val Lys Asn Tyr Val Asp Trp Ile Leu Lys Thr Met Gln Glu Asn 
         675                680                685
Ser Gly Pro Lys Lys Asp 
     690



<210> 2276
<211> 1355
<212> DNA
<213> Rattus norvegicus
<308> D88534
<400> 2276

atgctgatg  tgtggacat  tgcagtgct  ctgggagca  tagctggaa  agaagtttg  60
tttgacaaa  tcggctgct  cagtgatga  gccccgtgg  caggaacca  agacagacc  120
ctgaaagca  tgccctgga  cccagcaca  atcaacacc  gctttctcc  ctacaccaa  180
gagaaccaa  acaactacc  gaaaattac  tcagatgca  cgagtatca  aaactccaa  240
ttcaaaacg  acagaaaaa  ccgcatcat  atccacggc  tcattgaca  gggagagga  300
aactggcta  ctgacatgt  caagaacat  ttcaaagtg  agagtgtga  ctgcatctg  360
gtggactgg  aaggtggct  ccgggctac  tacacccag  ctacccaga  cgtccgggt  420
gtgggtgca  aagtggcat  attggttaa  gttctgaag  ctgacctcg  ctactcacc  480
gacaacgtc  acctgattg  ccacagcct  ggttcccac  ttgctgggg  ggcaggaaa  540
aggacattc  gagctattg  gaggatcac  gggttggac  cggctgaac  ttacttcca  600
ggcacacct  aagaagtcc  tctggaccc  accgatgcc  agtttgtgg  tgcaattca  660
acagatgct  cacccatca  ccccaactt  ggatttgga  tgagccaga  tgtgggtca  720
ctagatttc  ttcctaatg  agggatgga  atgcctgga  gtcagaaga  tatcctttc  780
caaatcgtt  acatcgacg  gatctggga  ggaactcgc  actttgctg  ctgtaacca  840
ttgagaagc  acaaatatt  caccgacag  atcgtcaac  cgactggct  ctctggctt  900
tcctgtagc  cttacaatg  tttttctgc  aataagtgc  tcccatgtg  gagtgaagg  960
tgcccacag  tgggtcact  tgctgacaa  taccctggg  agacaaaag  actctacca  1020
aaattttac  tgaacactg  tgacaagag  aacttcgca  gttggcggt  ccaggtgac  1080
gtcaccctc  ctggacaga  ggtcactgg  cacattcta  tttctttgt  tggaaatgg  1140
ggaaactct  aacagtatg  agttttcaa  ggctctctg  atccaggtg  cactcatgt  1200
aaggaattt  actctgata  ggatgttgg  gatttgcag  aagttaaat  tatttggta  1260
aacaatgtg  tcaacccaa  tctacccaa  gtgggagca  caaggattt  agtggaacg  1320
aatgacggc  gagtgttca  cttctgtag  caaga  1355



<210> 2277
<211> 451
<212> PRT
<213> Rattus norvegicus
<308> BAA13637
<400> 2277

Met Leu Met Leu Trp Thr Phe Ala Val Leu Leu Gly Ala Val Ala Gly 
  1               5                  10                  15
Lys Glu Val Cys Phe Asp Lys Leu Gly Cys Phe Ser Asp Asp Ala Pro 
             20                  25                  30
Trp Ser Gly Thr Ile Asp Arg Pro Leu Lys Ala Leu Pro Trp Ser Pro 
         35                  40                  45
Ala Gln Ile Asn Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Gln Asp 
     50                  55                  60
Asn Tyr Gln Lys Ile Thr Ser Asp Ala Ser Ser Ile Arg Asn Ser Asn 
 65                  70                  75                  80
Phe Lys Thr Asn Arg Lys Thr Arg Ile Ile Ile His Gly Phe Ile Asp 
                 85                  90                  95
Lys Gly Glu Glu Asn Trp Leu Ser Asp Met Cys Lys Asn Met Phe Lys 
             100                105                110
Val Glu Ser Val Asn Cys Ile Cys Val Asp Trp Lys Gly Gly Ser Arg 
         115                120                125
Ala Thr Tyr Thr Gln Ala Thr Gln Asn Val Arg Val Val Gly Ala Glu 
     130                135                140
Val Ala Leu Leu Val Asn Val Leu Lys Ser Asp Leu Gly Tyr Ser Pro 
 145                150                155                160
Asp Asn Val His Leu Ile Gly His Ser Leu Gly Ser His Val Ala Gly 
                 165                170                175
Glu Ala Gly Lys Arg Thr Phe Gly Ala Ile Gly Arg Ile Thr Gly Leu 
             180                185                190
Asp Ala Ala Glu Pro Tyr Phe Gln Gly Thr Pro Glu Glu Val Arg Leu 
         195                200                205
Asp Pro Thr Asp Ala Gln Phe Val Asp Ala Ile His Thr Asp Ala Ala 
     210                215                220
Pro Ile Ile Pro Asn Leu Gly Phe Gly Met Ser Gln Thr Val Gly His 
 225                230                235                240
Leu Asp Phe Phe Pro Asn Gly Gly Met Glu Met Pro Gly Cys Gln Lys 
                 245                250                255
Asn Ile Leu Ser Gln Ile Val Asp Ile Asp Gly Ile Trp Glu Gly Thr 
             260                265                270
Arg Asp Phe Ala Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr Thr 
         275                280                285
Asp Ser Ile Val Asn Pro Thr Gly Phe Ser Gly Phe Ser Cys Ser Ser 
     290                295                300
Tyr Asn Val Phe Ser Ala Asn Lys Cys Phe Pro Cys Gly Ser Glu Gly 
 305                310                315                320
Cys Pro Gln Met Gly His Tyr Ala Asp Lys Tyr Pro Gly Lys Thr Lys 
                 325                330                335
Glu Leu Tyr Gln Lys Phe Tyr Leu Asn Thr Gly Asp Lys Ser Asn Phe 
             340                345                350
Ala Arg Trp Arg Tyr Gln Val Thr Val Thr Leu Ser Gly Gln Lys Val 
         355                360                365
Thr Gly His Ile Leu Val Ser Leu Phe Gly Asn Gly Gly Asn Ser Lys 
     370                375                380
Gln Tyr Glu Val Phe Lys Gly Ser Leu His Pro Gly Asp Thr His Val 
 385                390                395                400
Lys Glu Phe Asp Ser Asp Met Asp Val Gly Asp Leu Gln Lys Val Lys 
                 405                410                415
Phe Ile Trp Tyr Asn Asn Val Ile Asn Pro Thr Leu Pro Lys Val Gly 
             420                425                430
Ala Ser Arg Ile Ser Val Glu Arg Asn Asp Gly Arg Val Phe Asn Phe 
         435                440                445
Cys Ser Gln 
     450



<210> 2278
<211> 1471
<212> DNA
<213> Homo sapiens
<308> NM_000936
<400> 2278

ggaactgcc  cgatgctgc  actttggac  ctttcactg  tgctgggag  agtagcagg  60
aaagaagtt  gctacgaaa  actcggctg  ttcagtgat  actccccat  gtcaggaat  120
acggaaaga  ccctccata  attgccttg  tctccaaaa  atgtcaaca  ccgcttcct  180
ctatatact  atgagaacc  aaacaactt  caagaagtt  ccgcagatt  atcaagcat  240
agtggctcc  atttcaaaa  aaatagaaa  actcgcttt  ttattcatg  attcataga  300
aagggagaa  aaaactggc  ggccaatgt  tgcaagaat  tgttcaagg  ggaaagtgt  360
aactgtatc  gtgtggact  gaaaggtgg  tcccgaact  gatacacac  agcctcgca  420
aacatcagg  tcgtgggag  agaagtggc  tattttgtt  aatttcttc  gtcggcgtt  480
ggttactca  cttccaacg  gcatgtcat  ggccacagc  tgggtgccc  cgctgctgg  540
gaggctgga  ggagaacca  tgggaccat  ggacgcatc  cagggttgg  cccagcaga  600
ccttgcttt  agggcacac  tgaattagt  cgattggac  ccagcgatg  caaatttgt  660
gatgtaatt  acacggatg  tgcccccat  gtccccaat  tggggtttg  aatgagcca  720
gtcgtgggc  acctagatt  ctttccaaa  ggaggagtg  aaatgcctg  atgtaaaaa  780
aacattctc  ctcagattg  ggacataga  ggaatctgg  aagggactc  agactttgc  840
gcctgtaat  acttaagaa  ctacaaata  tacactgat  gcatcgtca  ccctgatgg  900
tttgctgga  tcccctgtg  ctcttacaa  gtcttcact  caaacaagt  tttcccttg  960
ccaagtgga  gctgcccac  gatgggtca  tatgctgat  gatatcctg  gaaaacaaa  1020
gatgtgggc  agaaatttt  tctagacac  ggtgatgcc  gtaattttg  acgttggag  1080
tataaggta  ctgtcacac  gtctggaaa  aaggttaca  gacacatac  agtttcttt  1140
ttcggaaat  aaggaaact  taagcagta  gaaattttc  agggcactc  caaaccaga  1200
agtactcat  ccaatgaat  tgactcaga  gtggatgtt  gggacttgc  gatggttaa  1260
tttatttgg  ataacaatg  gatcaaccc  actttacct  gagtgggag  atccaagat  1320
atagtggag  caaatgttg  aaaacagtt  aacttctgt  gtccagaaa  cgtcaggga  1380
gaagttctg  tcaccctca  accgtgtta  gagactact  ttatttgac  aatgaattg  1440
cttctaata  aatctagtg  tgatgcaaa  a  1471



<210> 2279
<211> 465
<212> PRT
<213> Homo sapiens
<308> P16233
<400> 2279

Met Leu Pro Leu Trp Thr Leu Ser Leu Leu Leu Gly Ala Val Ala Gly 
  1               5                  10                  15
Lys Glu Val Cys Tyr Glu Arg Leu Gly Cys Phe Ser Asp Asp Ser Pro 
             20                  25                  30
Trp Ser Gly Ile Thr Glu Arg Pro Leu His Ile Leu Pro Trp Ser Pro 
         35                  40                  45
Lys Asp Val Asn Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Pro Asn 
     50                  55                  60
Asn Phe Gln Glu Val Ala Ala Asp Ser Ser Ser Ile Ser Gly Ser Asn 
 65                  70                  75                  80
Phe Lys Thr Asn Arg Lys Thr Arg Phe Ile Ile His Gly Phe Ile Asp 
                 85                  90                  95
Lys Gly Glu Glu Asn Trp Leu Ala Asn Val Cys Lys Asn Leu Phe Lys 
             100                105                110
Val Glu Ser Val Asn Cys Ile Cys Val Asp Trp Lys Gly Gly Ser Arg 
         115                120                125
Thr Gly Tyr Thr Gln Ala Ser Gln Asn Ile Arg Ile Val Gly Ala Glu 
     130                135                140
Val Ala Tyr Phe Val Glu Phe Leu Gln Ser Ala Phe Gly Tyr Ser Pro 
 145                150                155                160
Ser Asn Val His Val Ile Gly His Ser Leu Gly Ala His Ala Ala Gly 
                 165                170                175
Glu Ala Gly Arg Arg Thr Asn Gly Thr Ile Gly Arg Ile Thr Gly Leu 
             180                185                190
Asp Pro Ala Glu Pro Cys Phe Gln Gly Thr Pro Glu Leu Val Arg Leu 
         195                200                205
Asp Pro Ser Asp Ala Lys Phe Val Asp Val Ile His Thr Asp Gly Ala 
     210                215                220
Pro Ile Val Pro Asn Leu Gly Phe Gly Met Ser Gln Val Val Gly His 
 225                230                235                240
Leu Asp Phe Phe Pro Asn Gly Gly Val Glu Met Pro Gly Cys Lys Lys 
                 245                250                255
Asn Ile Leu Ser Gln Ile Val Asp Ile Asp Gly Ile Trp Glu Gly Thr 
             260                265                270
Arg Asp Phe Ala Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr Thr 
         275                280                285
Asp Ser Ile Val Asn Pro Asp Gly Phe Ala Gly Phe Pro Cys Ala Ser 
     290                295                300
Tyr Asn Val Phe Thr Ala Asn Lys Cys Phe Pro Cys Pro Ser Gly Gly 
 305                310                315                320
Cys Pro Gln Met Gly His Tyr Ala Asp Arg Tyr Pro Gly Lys Thr Asn 
                 325                330                335
Asp Val Gly Gln Lys Phe Tyr Leu Asp Thr Gly Asp Ala Ser Asn Phe 
             340                345                350
Ala Arg Trp Arg Tyr Lys Val Ser Val Thr Leu Ser Gly Lys Lys Val 
         355                360                365
Thr Gly His Ile Leu Val Ser Leu Phe Gly Asn Lys Gly Asn Ser Lys 
     370                375                380
Gln Tyr Glu Ile Phe Lys Gly Thr Leu Lys Pro Asp Ser Thr His Ser 
 385                390                395                400
Asn Glu Phe Asp Ser Asp Val Asp Val Gly Asp Leu Gln Met Val Lys 
                 405                410                415
Phe Ile Trp Tyr Asn Asn Val Ile Asn Pro Thr Leu Pro Arg Val Gly 
             420                425                430
Ala Ser Lys Ile Ile Val Glu Thr Asn Val Gly Lys Gln Phe Asn Phe 
         435                440                445
Cys Ser Pro Glu Thr Val Arg Glu Glu Val Leu Leu Thr Leu Thr Pro 
     450                455                460
Cys 
 465



<210> 2280
<211> 4562
<212> DNA
<213> Rattus norvegicus
<308> D88672
<400> 2280

ggctccttg  tgagttctg  tccctctgc  tccgaaccc  ctcgggcgc  ggggcccgc  60
tccaaggtg  tgggccccg  acgtagtgc  gctgaggtc  ggagccccg  gaaccgggc  120
gggacgttg  caggctgga  ctgctcggg  cttctgact  agccgctca  ccagatttc  180
ggatttctc  tctgggcgg  gagcgcgta  cttcctcat  cccgccggg  ccctcgctt  240
cagtcagtc  ggcctgact  tgagccctg  tgtcaccag  gctcctccc  tggacttaa  300
ctcgcccca  ttcgaggcc  tcccatctt  gctaggatg  ctgtaaccc  gacggacct  360
tttccctat  gggactacc  gaactccag  cagttgcac  tggagccag  tgaggttga  420
actctgaag  aaggagagg  tccagctga  cgaatgcat  cctttctgg  catctatga  480
cttcagcct  tgagagcac  ccccttggt  tttgctcct  gggtccctg  tatagccca  540
gtggtaggc  ccgaaagat  caccagcgg  tccaaggtg  gaacctgta  tctttattc  600
gttcgattg  cccatggcg  ctttacctg  acaaccaag  agaaattcc  acactttca  660
gagctgcat  gggacctcc  gagacacaa  gtcttgatg  gtctgctcc  tctggctcg  720
tttgctgcg  cccattctc  agcccgaga  gcagccaat  agaatattc  ctccctacc  780
cgaggaggt  ccgagggct  tgccagaca  acagccagc  agcagaagt  cctggaaaa  840
tacctcaac  gcctcctga  catgtcttt  tatcgaaat  accatgcca  gacagaatt  900
ctggaagtc  gtcaacttt  ctttatccc  gaccttggc  ccaaaggac  ggaaggggt  960
atccggaag  gctcaggtg  gcatcgagt  cctggcttc  cctgctgtg  tcgagacca  1020
gtttgttat  gatggtcca  gaggtggct  gtggtgaag  actccttcc  gctgtacat  1080
cgtccagag  ctggcgcca  ctcatttgt  caacttttt  accctggct  tgaggtcca  1140
gtggggaaa  ggagcacag  ggcacggta  ggggtgagg  tcgacacct  ccacaggtc  1200
ctgatcctc  aatgcagca  ctaccggca  gcacggtgg  ggggccagg  gatcacgga  1260
ctggcacag  gtccgggca  agattttct  cagctacac  agcatgaca  ctatgcccc  1320
ccccggcct  gcaccctgg  ccggtggtt  gtgaatggg  caggttact  tgctgctgt  1380
gcagatgcc  tcctccgag  tcgagagga  attttcatc  cagactggt  gctgagtcc  1440
gagatttac  tgaagcgtc  agcccactc  gatgactgg  gactggaca  tatgctcaa  1500
aggaaggcg  aagaaggtg  ccgtgtttc  atactgctg  ttaaggaag  ggaactggc  1560
ttgggcatc  acagtggct  tagcaagag  acactgatg  tactgcacc  caacataaa  1620
gtgatgcga  acccagacc  tgtaacatt  tgggctcat  atgagaagc  cctggtggt  1680
gaccaagcg  tggcattct  gggtgggct  gaccttgcc  atggccgct  ggatgatgt  1740
cagtaccga  tgactgacc  gggggaccc  tccgaatct  cagattcac  gactcccac  1800
ccaggttca  atcctgcag  cactccaga  ctctcgcat  atcacttct  ctggctggg  1860
aaagactac  gcaacctca  taccaagga  tgggtacag  tggaccggc  ttttgaaga  1920
ttcatcgac  gggagacca  acccagaat  ccatggagg  atgttggag  ggttgtaca  1980
ggagtagct  cccgggacc  tgcccggca  ttcatccag  gctggaact  caccaagac  2040
atcaaggcc  gatacaaga  acctcagta  ccctacctg  tgcctaagt  cgccagcac  2100
gcaaaccat  ttcccttca  aatcccagg  gcgcagtgc  ccactgtgc  ggtcttgcg  2160
tctgtggat  gatggtcag  agggacttt  gagagctcc  tcctcaatg  ctacctaca  2220
accatccga  agagccagc  ctttctcta  attgagaat  agttcttca  cagctgctc  2280
gatgggcgt  cagttctga  caaggtggg  gatgagatt  tggacagga  cctaaaggc  2340
catgaacag  ggcagtgtt  ccgagtcta  gtgcttctg  ctttgctcc  tggctttga  2400
ggggacatc  ccacagggg  tggcaactc  atccaggcc  ttctgcact  cacctacag  2460
accctgtgt  gtggggaat  ttcaatctt  catcgtctc  aagcagcca  ggggacagc  2520
tggcgggat  acatgtcca  ctgtgggct  cgcacacat  gagagctgg  cgggcaccc  2580
atctccgag  tcatctata  ccacagcaa  ttgctcatt  cagatgaca  aacagtcat  2640
atcggctct  caaacatca  cgacaggag  ttgctgggg  agcgcgaca  tgagctagc  2700
atactgatc  aggacacag  aatggagcc  tccctcatg  atggggtgg  gtaccaggc  2760
ggcagattt  ccttgagtc  gcggaagca  tgtttcagt  tcattcttg  ggcaaatac  2820
tggccagac  tggatctcc  agaccctgt  tgtgatgac  tcttccagc  gtggcagga  2880
acagcggag  acaatgcca  catctatga  cagatcttc  gctgcctgc  gtccaatgc  2940
actcgttcc  tgcgggctc  ccgggagta  gtggctgtg  agtccttgg  tacagtcag  3000
ccttctttg  ctcagtctg  gcttgccca  atccggggc  acttagttc  cttccccct  3060
aagtttctg  aggatgagt  cttgttgcc  ccactgggg  gcaaagagg  gatgatacc  3120
ttagaagtg  ggacatagc  ggggcttcc  ctcagcggc  gttgctagc  gttgggccc  3180
atcgtgcct  gatccttgc  ccacaccct  agttctgag  gcagtgccc  ttgatcctt  3240
gggaggaca  ctctgagga  tcctagaga  tcacagagg  cctttactt  agaagtagc  3300
aaagggagc  ctcccaagc  tggcctggg  aagcaggag  gagttctag  gaggtttgc  3360
ttcttgtca  catgttcag  ccactatgc  acagaaccc  agtcctacg  ggaggcctg  3420
ggtcaagcc  tttattcca  gaaaaggga  tcctgccct  ggtcgtctt  atctcactc  3480
tcctcctgc  cttgaaccc  tacatgccc  agggcctct  ccagcccgt  gctgcaaag  3540
tgggggggg  ggagtatag  gccactttg  ctgcagtcc  caccagcgg  ggtgaggac  3600
ccttaactg  ctccaccag  ctgctgaca  acactaact  tgtaccggt  caccaagca  3660
ttcataaat  aatgtgtag  aaaggccat  cttcttctt  gagatggat  ttgtcttag  3720
tgctccctg  ctcagttct  acttctttc  tctgcttgc  tctctgtgc  tgcttgccc  3780
ccctttctc  ctccctccc  ttccttctt  cttttcctt  cttcctccc  ccctttcct  3840
cttcccctt  cttccttcc  tccttcctt  cttccttcc  tccttcctt  cttccaggg  3900
gtggggtgg  gttgatttc  aaatagagt  tctctgtgt  gccctagct  tcctggaac  3960
ctgttaaca  ggctgccct  gaactcgga  agatccacc  gcctctgcc  cctaagtgc  4020
tggacatag  cttgggcca  agctccatc  ctgtgcttc  cagcagctt  tgagttcat  4080
cacctaact  ctgaagatc  gggctaatt  tgtgtgtgt  tgtgtgtgt  tgtgtgtgt  4140
tgtgtgtgt  tgtgtgtgc  tgatacata  cttcataac  tttcatatg  ctgaagtat  4200
ttgcaatta  aaaactgct  aacacagat  gccacagaa  caggaagaa  ataaggaga  4260
tggagaatt  ggaaggcat  atagaaggc  gtgggggtg  gtgagaatg  gaccagaag  4320
tattaggtt  ctctcccat  cctctagtt  tcttgagaa  tgaattcta  ggttagtga  4380
agatgcttc  gcagaggaa  atgcttcct  ttaggctta  caacttgag  tcgatcccc  4440
ggacccaca  tctaggagg  gaaaacagt  tcctgaaag  tgtcctctg  cctccacac  4500
cagaccatg  cattcctgt  tgtgctcac  ataaataaa  tcattttca  aatcaaaaa  4560
aa  4562



<210> 2281
<211> 933
<212> PRT
<213> Rattus norvegicus
<308> P70498
<400> 2281

Met Thr Val Thr Gln Thr Asp Leu Phe Pro Tyr Gly Asp Tyr Leu Asn 
  1               5                  10                  15
Ser Ser Gln Leu His Met Glu Pro Asp Val Val Asp Thr Leu Lys Glu 
             20                  25                  30
Gly Glu Asp Pro Ala Asp Arg Met His Pro Phe Leu Ala Ile Tyr Asp 
         35                  40                  45
Leu Gln Pro Leu Arg Ala His Pro Leu Val Phe Ala Pro Gly Val Pro 
     50                  55                  60
Val Ile Ala Gln Val Val Gly Thr Glu Arg Tyr Thr Ser Gly Ser Lys 
 65                  70                  75                  80
Val Gly Thr Cys Thr Leu Tyr Ser Val Arg Leu Thr His Gly Asp Phe 
                 85                  90                  95
Thr Trp Thr Thr Lys Lys Lys Phe Arg His Phe Gln Glu Leu His Arg 
             100                105                110
Asp Leu Gln Arg His Lys Val Leu Met Ser Leu Leu Asn Leu Ala Arg 
         115                120                125
Phe Ala Ala Ala His Ser Pro Ala Arg Glu Ala Ala Asn Glu Asn Ile 
     130                135                140
Pro Ser Leu Pro Arg Gly Gly Ser Glu Gly Ser Ala Arg His Thr Ala 
 145                150                155                160
Ser Lys Gln Lys Tyr Leu Glu Asn Tyr Leu Asn Arg Leu Leu Thr Met 
                 165                170                175
Ser Phe Tyr Arg Asn Tyr His Ala Met Thr Glu Phe Leu Glu Val Ser 
             180                185                190
Gln Leu Ser Phe Ile Pro Asp Leu Gly Ser Lys Gly Leu Glu Gly Val 
         195                200                205
Ile Arg Lys Arg Ser Gly Gly His Arg Val Pro Gly Phe Thr Cys Cys 
     210                215                220
Gly Arg Asp Gln Val Cys Tyr Arg Trp Ser Lys Arg Trp Leu Val Val 
 225                230                235                240
Lys Asp Ser Phe Leu Leu Tyr Met Arg Pro Glu Thr Gly Ala Ile Ser 
                 245                250                255
Phe Val Gln Leu Phe Asp Pro Gly Phe Glu Val Gln Val Gly Lys Arg 
             260                265                270
Ser Thr Glu Ala Arg Tyr Gly Val Arg Ile Asp Thr Ser His Arg Ser 
         275                280                285
Leu Ile Leu Lys Cys Ser Ser Tyr Arg Gln Ala Arg Trp Trp Gly Gln 
     290                295                300
Glu Ile Thr Glu Leu Ala Gln Gly Pro Gly Arg Asp Phe Leu Gln Leu 
 305                310                315                320
His Gln His Asp Ser Tyr Ala Pro Pro Arg Pro Gly Thr Leu Ala Arg 
                 325                330                335
Trp Phe Val Asn Gly Ala Gly Tyr Phe Ala Ala Val Ala Asp Ala Ile 
             340                345                350
Leu Arg Ala Arg Glu Glu Ile Phe Ile Thr Asp Trp Trp Leu Ser Pro 
         355                360                365
Glu Ile Tyr Leu Lys Arg Pro Ala His Ser Asp Asp Trp Arg Leu Asp 
     370                375                380
Ile Met Leu Lys Arg Lys Ala Glu Glu Gly Val Arg Val Ser Ile Leu 
 385                390                395                400
Leu Phe Lys Glu Val Glu Leu Ala Leu Gly Ile Asn Ser Gly Tyr Ser 
                 405                410                415
Lys Arg Thr Leu Met Leu Leu His Pro Asn Ile Lys Val Met Arg His 
             420                425                430
Pro Asp Leu Val Thr Leu Trp Ala His His Glu Lys Leu Leu Val Val 
         435                440                445
Asp Gln Ala Val Ala Phe Leu Gly Gly Leu Asp Leu Ala Tyr Gly Arg 
     450                455                460
Trp Asp Asp Val Gln Tyr Arg Leu Thr Asp Leu Gly Asp Pro Ser Glu 
 465                470                475                480
Ser Ala Asp Ser Gln Thr Pro Thr Pro Gly Ser Asp Pro Ala Ala Thr 
                 485                490                495
Pro Asp Leu Ser His Asn His Phe Phe Trp Leu Gly Lys Asp Tyr Ser 
             500                505                510
Asn Leu Ile Thr Lys Asp Trp Val Gln Leu Asp Arg Pro Phe Glu Asp 
         515                520                525
Phe Ile Asp Arg Glu Thr Thr Pro Arg Met Pro Trp Arg Asp Val Gly 
     530                535                540
Val Val Val His Gly Val Ala Ala Arg Asp Leu Ala Arg His Phe Ile 
 545                550                555                560
Gln Arg Trp Asn Phe Thr Lys Thr Ile Lys Ala Arg Tyr Lys Ile Pro 
                 565                570                575
Gln Tyr Pro Tyr Leu Leu Pro Lys Ser Ala Ser Thr Ala Asn His Leu 
             580                585                590
Pro Phe Ile Ile Pro Gly Gly Gln Cys Ala Thr Val Gln Val Leu Arg 
         595                600                605
Ser Val Asp Arg Trp Ser Ala Gly Thr Leu Glu Ser Ser Ile Leu Asn 
     610                615                620
Ala Tyr Leu His Thr Ile Arg Glu Ser Gln His Phe Leu Tyr Ile Glu 
 625                630                635                640
Asn Gln Phe Phe Ile Ser Cys Ser Asp Gly Arg Thr Val Leu Asn Lys 
                 645                650                655
Val Gly Asp Glu Ile Val Asp Arg Ile Leu Lys Ala His Glu Gln Gly 
             660                665                670
Gln Cys Phe Arg Val Tyr Val Leu Leu Pro Leu Leu Pro Gly Phe Glu 
         675                680                685
Gly Asp Ile Ser Thr Gly Gly Gly Asn Ser Ile Gln Ala Ile Leu His 
     690                695                700
Phe Thr Tyr Arg Thr Leu Cys Arg Gly Glu Tyr Ser Ile Leu His Arg 
 705                710                715                720
Leu Lys Ala Ala Met Gly Thr Ala Trp Arg Asp Tyr Met Ser Ile Cys 
                 725                730                735
Gly Leu Arg Thr His Gly Glu Leu Gly Gly His Pro Ile Ser Glu Leu 
             740                745                750
Ile Tyr Ile His Ser Lys Leu Leu Ile Ala Asp Asp Arg Thr Val Ile 
         755                760                765
Ile Gly Ser Ala Asn Ile Asn Asp Arg Ser Leu Leu Gly Lys Arg Asp 
     770                775                780
Ser Glu Leu Ala Ile Leu Ile Lys Asp Thr Glu Met Glu Pro Ser Leu 
 785                790                795                800
Met Asp Gly Val Glu Tyr Gln Ala Gly Arg Phe Ala Leu Ser Leu Arg 
                 805                810                815
Gly Arg Cys Phe Ser Val Ile Leu Gly Ala Asn Thr Trp Pro Asp Leu 
             820                825                830
Asp Leu Arg Asp Pro Val Cys Asp Asp Phe Phe Gln Leu Trp Gln Glu 
         835                840                845
Thr Ala Glu Asn Asn Ala Thr Ile Tyr Glu Gln Ile Phe Arg Cys Leu 
     850                855                860
Pro Ser Asn Ala Thr Arg Ser Leu Arg Ala Leu Arg Glu Tyr Val Ala 
 865                870                875                880
Val Glu Ser Leu Ala Thr Val Ser Pro Ser Leu Ala Gln Ser Glu Leu 
                 885                890                895
Ala His Ile Arg Gly His Leu Val His Phe Pro Leu Lys Phe Leu Glu 
             900                905                910
Asp Glu Ser Leu Leu Pro His Trp Gly Ala Lys Arg Gly Met Ile Pro 
         915                920                925
Leu Glu Val Trp Thr 
     930



<210> 2282
<211> 3450
<212> DNA
<213> Homo sapiens
<308> AF038441
<400> 2282

tactccact  aataatctc  tagaggccc  cccgtccgc  cttggctcg  gaacccccg  60
gggcgctgg  tccgtctgc  agggatgac  gcgacccct  agagcctct  ccccactgg  120
gacgaactg  gctccagcc  gctccagat  gagtccgat  aggtggaca  cctgaagga  180
ggagaggac  cagccgacc  gatgcaccc  tttctggcc  tctatgagc  tcagtctct  240
aaagtgcac  ccttggtgt  cgcacctgg  gtccctgtc  cagcccagg  ggtgggcac  300
gaaagatat  ccagcggat  caaggtggg  acctgcact  tgtattctg  ccgcttgac  360
cacggcgac  tttcctgga  aaccaagaa  aaataccgt  attttcagg  gctgcatcg  420
gacctcctg  gacacaaag  cttgatgag  ctgctccct  tggctcgtt  tgccgttgc  480
tattctcca  cccgagatg  aggcaacag  gagatgccc  ctctacccc  ggcaggtcc  540
gagggctcc  ccagacatg  agccagcaa  cagaaatgc  tggagaatt  cctcaaccg  600
ctcttgacc  tgtctttct  tcgcaacta  catgccatg  cagagttcc  ggaagtcag  660
cagctgtcc  ttatcccgg  cttgggccg  aaaggactg  aggggatga  ccggaagtg  720
tcaggtggc  accgtgttc  tggcctcac  tgctgtggc  gagaccaag  ttgttatcg  780
tggtccaag  ggtggctgg  ggtgaagga  tccttcctg  tgtacatgt  cctcgagac  840
ggtgccatc  catttgttc  gctctttga  cctggcttt  aggtgcaag  ggggaaaag  900
agcacggag  cacggcacg  cgtgcggat  gatacctcc  acaggtcct  gattctcaa  960
tgcagcagc  accggcagg  acggtggtg  gcccaagag  tcactgagc  ggcacaggg  1020
ccaggcaga  acttcctac  gctgcaccg  catgacaga  acgccccac  ccggcctgg  1080
accttggcc  ggtggtttg  gaatggggc  ggttacttt  ctgctgtgg  agatgccat  1140
cttcgagct  aagaggaga  tttcatcac  gactggtgg  tgagtcctg  ggtttacct  1200
aagcgtccg  cccattcag  tgactggag  ctggacatt  tgctcaaga  gaaggcgga  1260
gagggtgtc  gtgtgtcta  tctgctgtt  aaagaagtg  aattggcct  gggcatcaa  1320
agtggctat  gcaagaggg  gctgatgct  ctgcacccc  acataaagg  gatgcgtca  1380
ccagaccaa  tgacgttgt  ggcccatca  gagaagccc  tggtggtgg  ccaagtggt  1440
gcattcctg  ggggactgg  ccttgccta  ggccgctgg  atgacctgc  ctaccgact  1500
actgacctt  gagactcct  tgaatcagc  gcttcccag  ctcccaccc  gcgcccaga  1560
tcaccagcc  ccccagacc  ctctcacaa  caattcttc  ggctgggca  ggggtacag  1620
aatcttatc  ccaaggact  ggtgcagct  gaccggcct  tcgaagatt  cattgacag  1680
gagacgacc  ctcggatgc  atggcggga  gttggggtg  tcgtccatg  cctaccggc  1740
cgggacctt  cccggcact  catccagcg  tggaatttc  ccaagacca  caaggccaa  1800
tacaagact  ccacatacc  ctacctgct  cccaagtct  ccagcacgg  caatcagct  1860
cccttcaca  ttccaggag  gcagtgcac  accgtacag  tcttgcgat  agtggaccg  1920
tggtcagca  ggactctgg  gaactccat  ctcaatgcc  acctgcaca  catcagggg  1980
agccagcac  tcctctaca  tgagaatca  ttcttcatt  gctgctcag  tgggcggac  2040
gttctgaac  aggtgggcg  tgagattgt  gacagaatc  tgaaggccc  caaacaggg  2100
tggtgttac  gagtctacg  gcttttgcc  ttactccct  gcttcgagg  tgacatctc  2160
acgggcggt  gcaactcca  ccaggccat  ctgcacttt  cttacagga  cctgtgtcg  2220
ggggagtat  caatcctgc  tcgccttaa  gcagccatg  ggacagcat  gcgggacta  2280
atttccatc  gcgggcttc  tacacacgg  gagctgggc  ggcaccccg  ctcggagct  2340
atctacatc  acagcaagg  gctcatcgc  gatgaccgg  cagtcatca  tggttctgc  2400
aacatcaat  accggagct  gctggggaa  cggggcagt  agctggccg  gctgatcga  2460
gacacagag  cggaaccat  cctcatgaa  ggggcagag  atcaggcgg  cagtgtgat  2520
cttggagca  atacccggc  agacttgga  ctccgagac  ccatctgtg  tgacttctt  2580
cagttgtgg  aagacatgg  tgagagcaa  gccaatatc  atgagcaga  cttccgctg  2640
ctgccatcc  atgccacgc  ttccctgcg  actctccgg  agtacgtgg  cgtggagcc  2700
ttggccacg  tcagtcccc  cttggctcg  tctgagctc  cccaggtcc  gggccacct  2760
gtccacttc  ccctcaagt  cctagagga  gagtctttg  tgcccccgc  gggtagcaa  2820
gagggcatg  tccccctag  agtgtggac  tagttgagg  ccccgtcag  gagaggtca  2880
cagctgctg  gccccacca  gtctggctc  ctgcccctt  accccaagg  ctgagggca  2940
tgccctttg  gatctgggg  ggcaggcat  cctgaaggg  actagaggt  ttacagcgg  3000
cccttacgt  agaaatagc  gaaaagggc  ctcccaacc  tgggctggg  aggaggaga  3060
agtcccaga  ctcatcccc  ctgctgccc  gtgcaaacc  cttctccat  ctgcaaagg  3120
gaagcacag  tcctgccag  gtgagcagg  tcaagcctc  tattccagg  gaagggggc  3180
ctgccccag  ccctactac  cattgttcc  ttcctcttc  tgcccttga  ccccctccc  3240
gtcccaggg  cctcccagc  cattgctgc  aaggtggag  gaaggataa  gccacttct  3300
gcttcagcc  ccaccaggg  aaggaagga  ggcacatta  ctccctcca  cagcctgct  3360
acagacact  actttgtat  cgttcaata  gcatttcat  aataaaggt  tagaaaaaa  3420
aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  3450



<210> 2283
<211> 933
<212> PRT
<213> Homo sapiens
<308> O14939
<400> 2283

Met Thr Ala Thr Pro Glu Ser Leu Phe Pro Thr Gly Asp Glu Leu Asp 
  1               5                  10                  15
Ser Ser Gln Leu Gln Met Glu Ser Asp Glu Val Asp Thr Leu Lys Glu 
             20                  25                  30
Gly Glu Asp Pro Ala Asp Arg Met His Pro Phe Leu Ala Ile Tyr Glu 
         35                  40                  45
Leu Gln Ser Leu Lys Val His Pro Leu Val Phe Ala Pro Gly Val Pro 
     50                  55                  60
Val Thr Ala Gln Val Val Gly Thr Glu Arg Tyr Thr Ser Gly Ser Lys 
 65                  70                  75                  80
Val Gly Thr Cys Thr Leu Tyr Ser Val Arg Leu Thr His Gly Asp Phe 
                 85                  90                  95
Ser Trp Thr Thr Lys Lys Lys Tyr Arg His Phe Gln Glu Leu His Arg 
             100                105                110
Asp Leu Leu Arg His Lys Val Leu Met Ser Leu Leu Pro Leu Ala Arg 
         115                120                125
Phe Ala Val Ala Tyr Ser Pro Ala Arg Asp Ala Gly Asn Arg Glu Met 
     130                135                140
Pro Ser Leu Pro Arg Ala Gly Pro Glu Gly Ser Thr Arg His Ala Ala 
 145                150                155                160
Ser Lys Gln Lys Tyr Leu Glu Asn Tyr Leu Asn Arg Leu Leu Thr Met 
                 165                170                175
Ser Phe Tyr Arg Asn Tyr His Ala Met Thr Glu Phe Leu Glu Val Ser 
             180                185                190
Gln Leu Ser Phe Ile Pro Asp Leu Gly Arg Lys Gly Leu Glu Gly Met 
         195                200                205
Ile Arg Lys Arg Ser Gly Gly His Arg Val Pro Gly Leu Thr Cys Cys 
     210                215                220
Gly Arg Asp Gln Val Cys Tyr Arg Trp Ser Lys Arg Trp Leu Val Val 
 225                230                235                240
Lys Asp Ser Phe Leu Leu Tyr Met Cys Leu Glu Thr Gly Ala Ile Ser 
                 245                250                255
Phe Val Gln Leu Phe Asp Pro Gly Phe Glu Val Gln Val Gly Lys Arg 
             260                265                270
Ser Thr Glu Ala Arg His Gly Val Arg Ile Asp Thr Ser His Arg Ser 
         275                280                285
Leu Ile Leu Lys Cys Ser Ser Tyr Arg Gln Ala Arg Trp Trp Ala Gln 
     290                295                300
Glu Ile Thr Glu Leu Ala Gln Gly Pro Gly Arg Asp Phe Leu Gln Leu 
 305                310                315                320
His Arg His Asp Ser Tyr Ala Pro Pro Arg Pro Gly Thr Leu Ala Arg 
                 325                330                335
Trp Phe Val Asn Gly Ala Gly Tyr Phe Ala Ala Val Ala Asp Ala Ile 
             340                345                350
Leu Arg Ala Gln Glu Glu Ile Phe Ile Thr Asp Trp Trp Leu Ser Pro 
         355                360                365
Glu Val Tyr Leu Lys Arg Pro Ala His Ser Asp Asp Trp Arg Leu Asp 
     370                375                380
Ile Met Leu Lys Arg Lys Ala Glu Glu Gly Val Arg Val Ser Ile Leu 
 385                390                395                400
Leu Phe Lys Glu Val Glu Leu Ala Leu Gly Ile Asn Ser Gly Tyr Ser 
                 405                410                415
Lys Arg Ala Leu Met Leu Leu His Pro Asn Ile Lys Val Met Arg His 
             420                425                430
Pro Asp Gln Val Thr Leu Trp Ala His His Glu Lys Leu Leu Val Val 
         435                440                445
Asp Gln Val Val Ala Phe Leu Gly Gly Leu Asp Leu Ala Tyr Gly Arg 
     450                455                460
Trp Asp Asp Leu His Tyr Arg Leu Thr Asp Leu Gly Asp Ser Ser Glu 
 465                470                475                480
Ser Ala Ala Ser Gln Pro Pro Thr Pro Arg Pro Asp Ser Pro Ala Thr 
                 485                490                495
Pro Asp Leu Ser His Asn Gln Phe Phe Trp Leu Gly Lys Asp Tyr Ser 
             500                505                510
Asn Leu Ile Thr Lys Asp Trp Val Gln Leu Asp Arg Pro Phe Glu Asp 
         515                520                525
Phe Ile Asp Arg Glu Thr Thr Pro Arg Met Pro Trp Arg Asp Val Gly 
     530                535                540
Val Val Val His Gly Leu Pro Ala Arg Asp Leu Ala Arg His Phe Ile 
 545                550                555                560
Gln Arg Trp Asn Phe Thr Lys Thr Thr Lys Ala Lys Tyr Lys Thr Pro 
                 565                570                575
Thr Tyr Pro Tyr Leu Leu Pro Lys Ser Thr Ser Thr Ala Asn Gln Leu 
             580                585                590
Pro Phe Thr Leu Pro Gly Gly Gln Cys Thr Thr Val Gln Val Leu Arg 
         595                600                605
Ser Val Asp Arg Trp Ser Ala Gly Thr Leu Glu Asn Ser Ile Leu Asn 
     610                615                620
Ala Tyr Leu His Thr Ile Arg Glu Ser Gln His Phe Leu Tyr Ile Glu 
 625                630                635                640
Asn Gln Phe Phe Ile Ser Cys Ser Asp Gly Arg Thr Val Leu Asn Lys 
                 645                650                655
Val Gly Asp Glu Ile Val Asp Arg Ile Leu Lys Ala His Lys Gln Gly 
             660                665                670
Trp Cys Tyr Arg Val Tyr Val Leu Leu Pro Leu Leu Pro Gly Phe Glu 
         675                680                685
Gly Asp Ile Ser Thr Gly Gly Gly Asn Ser Ile Gln Ala Ile Leu His 
     690                695                700
Phe Thr Tyr Arg Thr Leu Cys Arg Gly Glu Tyr Ser Ile Leu His Arg 
 705                710                715                720
Leu Lys Ala Ala Met Gly Thr Ala Trp Arg Asp Tyr Ile Ser Ile Cys 
                 725                730                735
Gly Leu Arg Thr His Gly Glu Leu Gly Gly His Pro Val Ser Glu Leu 
             740                745                750
Ile Tyr Ile His Ser Lys Val Leu Ile Ala Asp Asp Arg Thr Val Ile 
         755                760                765
Ile Gly Ser Ala Asn Ile Asn Asp Arg Ser Leu Leu Gly Lys Arg Asp 
     770                775                780
Ser Glu Leu Ala Val Leu Ile Glu Asp Thr Glu Thr Glu Pro Ser Leu 
 785                790                795                800
Met Asn Gly Ala Glu Tyr Gln Ala Gly Arg Phe Ala Leu Ser Leu Arg 
                 805                810                815
Lys His Cys Phe Gly Val Ile Leu Gly Ala Asn Thr Arg Pro Asp Leu 
             820                825                830
Asp Leu Arg Asp Pro Ile Cys Asp Asp Phe Phe Gln Leu Trp Gln Asp 
         835                840                845
Met Ala Glu Ser Asn Ala Asn Ile Tyr Glu Gln Ile Phe Arg Cys Leu 
     850                855                860
Pro Ser Asn Ala Thr Arg Ser Leu Arg Thr Leu Arg Glu Tyr Val Ala 
 865                870                875                880
Val Glu Pro Leu Ala Thr Val Ser Pro Pro Leu Ala Arg Ser Glu Leu 
                 885                890                895
Thr Gln Val Gln Gly His Leu Val His Phe Pro Leu Lys Phe Leu Glu 
             900                905                910
Asp Glu Ser Leu Leu Pro Pro Leu Gly Ser Lys Glu Gly Met Ile Pro 
         915                920                925
Leu Glu Val Trp Thr 
     930



<210> 2284
<211> 1523
<212> DNA
<213> Rattus norvegicus
<308> D88890
<400> 2284

acttctaca  caagatccg  cctggggag  atgagcagt  cgagagcac  atcggcttc  60
agctcccta  ccttcacct  cattgcgcc  cggcggctt  cggacgagc  tctgactcg  120
gcacgcgtt  gactccttg  tccgtgtta  aagacgggt  gggtgggta  ccgacatcg  180
cgccgaccc  gtgccgtcg  agccaagat  tccggtccc  ccaccgaca  gccggccgc  240
atccagatc  gccggatca  gcgtccgga  gatgccaac  tggccggca  tgttcacgg  300
gggaccatt  taaagatga  cgaggaggc  ggggtcatc  tcagcaccc  gcactgtaa  360
agccagaat  gggagcgct  tgtggctgc  ctggcccgg  tggagcgca  tgacttcct  420
tcgcccatg  gcatcggtg  ggtggctca  gtcagcgca  agatcacct  tacttccaa  480
cactctgtg  aggtccagg  ccacgtgtt  tcggagaac  tcctcacag  taccaaaaa  540
ctgaccaat  aggccacct  gtggtatgt  cccctgtca  tgaagaatg  ggacaaggt  600
cttgaggtg  ctcctattg  gtatttacg  caggaacag  aggaggagg  tcggaaacg  660
tatgaagcc  agaagctag  acgcatgga  accaagtgg  ggaacggag  cattgtcca  720
cccatcctg  acccagagc  gaacacagt  agctacagc  agtccagcc  gatccacct  780
gtggggccc  cagactgca  tcttcatgg  ttcgtgcac  gaggtgtca  catgaagct  840
atggatgag  tggccggga  tgtggctgc  cgccactgc  agaccaata  agtgactgc  900
tctgtggat  ctattaatt  ccatgacaa  atccggaaa  gctgtgtca  caccatctc  960
ggacgcatg  ccttcacaa  caataagtc  atggaaatt  aggtcctgg  ggacgctga  1020
cctgtggtg  acaactcac  gaagcgcta  cgggctgcc  gtgccttct  cacctacgt  1080
tccctgaat  aggagggca  gccgctgcc  gtgcctcag  ttgtgccgg  gacggagga  1140
gagaagaag  gttttgaag  aggcaaagg  cgctatctg  agatgaagg  gaagcgaca  1200
ggccataca  agcctcagc  ctagatgtc  tcctccctc  catcctgtc  cgtcctggg  1260
cagcacagt  gtggcagta  tcctgtgtg  agtcactta  aagtcgccc  cttggccaa  1320
ccccgattt  ctttgagag  tggtgttgt  aagtaccgt  tgacagtgt  acctgtggc  1380
tgttcccaa  acctgtgca  caaagcttt  tttatatcc  tccagtccc  gtcccatgt  1440
gtcccaaag  ccatcgtgg  caccagagc  cactgactg  cctggagaa  ccagcacca  1500
taataaagc  gctgtctgg  tgg  1523



<210> 2285
<211> 338
<212> PRT
<213> Rattus norvegicus
<308> BAA19626
<400> 2285

Met Ser Gly Pro Thr Thr Asp Thr Pro Ala Ala Ile Gln Ile Cys Arg 
  1               5                  10                  15
Ile Met Arg Pro Asp Asp Ala Asn Val Ala Gly Asn Val His Gly Gly 
             20                  25                  30
Thr Ile Leu Lys Met Ile Glu Glu Ala Gly Val Ile Ile Ser Thr Arg 
         35                  40                  45
His Cys Asn Ser Gln Asn Gly Glu Arg Cys Val Ala Ala Leu Ala Arg 
     50                  55                  60
Val Glu Arg Thr Asp Phe Leu Ser Pro Met Cys Ile Gly Glu Val Ala 
 65                  70                  75                  80
His Val Ser Ala Glu Ile Thr Tyr Thr Ser Lys His Ser Val Glu Val 
                 85                  90                  95
Gln Val His Val Leu Ser Glu Asn Ile Leu Thr Gly Thr Lys Lys Leu 
             100                105                110
Thr Asn Lys Ala Thr Leu Trp Tyr Val Pro Leu Ser Leu Lys Asn Val 
         115                120                125
Asp Lys Val Leu Glu Val Pro Pro Ile Val Tyr Leu Arg Gln Glu Gln 
     130                135                140
Glu Glu Glu Gly Arg Lys Arg Tyr Glu Ala Gln Lys Leu Glu Arg Met 
 145                150                155                160
Glu Thr Lys Trp Arg Asn Gly Asp Ile Val Gln Pro Ile Leu Asn Pro 
                 165                170                175
Glu Pro Asn Thr Val Ser Tyr Ser Gln Ser Ser Leu Ile His Leu Val 
             180                185                190
Gly Pro Ser Asp Cys Thr Leu His Gly Phe Val His Gly Gly Val Thr 
         195                200                205
Met Lys Leu Met Asp Glu Val Ala Gly Ile Val Ala Ala Arg His Cys 
     210                215                220
Lys Thr Asn Ile Val Thr Ala Ser Val Asp Ala Ile Asn Phe His Asp 
 225                230                235                240
Lys Ile Arg Lys Gly Cys Val Ile Thr Ile Ser Gly Arg Met Thr Phe 
                 245                250                255
Thr Ser Asn Lys Ser Met Glu Ile Glu Val Leu Val Asp Ala Asp Pro 
             260                265                270
Val Val Asp Asn Ser Gln Lys Arg Tyr Arg Ala Ala Ser Ala Phe Phe 
         275                280                285
Thr Tyr Val Ser Leu Asn Gln Glu Gly Lys Pro Leu Pro Val Pro Gln 
     290                295                300
Leu Val Pro Glu Thr Glu Asp Glu Lys Lys Arg Phe Glu Glu Gly Lys 
 305                310                315                320
Gly Arg Tyr Leu Gln Met Lys Ala Lys Arg Gln Gly His Thr Glu Pro 
                 325                330                335
Gln Pro 
             340



<210> 2286
<211> 981
<212> DNA
<213> Rattus norvegicus
<308> D89069
<400> 2286

tcctttggt  tccgacggc  tttctaccc  cacgcagcc  tgtcttccg  cagacccgt  60
gcactggtg  ctggtgcta  caaaggaat  ggattcgcg  tcgtacgtg  tctctgtcg  120
aaattcttg  gggacgtgg  cctcacggc  cgggacgag  cacggggcc  cgaggcggt  180
aagcagctg  agaccgagg  cctgagccc  cgcttccac  agctggaca  cgacaaccc  240
cagagcatc  gcgcgctgc  tgactttct  cttcaggag  acggaggac  gaacgtgct  300
gtcaacaat  cgggcatcg  cttcaaagt  gttgacccc  cccccttcc  cattcaagc  360
gaggtgaca  tgaaaacca  cttttttgg  acccaagat  tctgcaagg  gctactccc  420
ataataaaa  cccaaggca  agtggtgaa  gtatcaagc  gcatgagtc  cagggccct  480
aaaagctgc  gcccggagc  gcagcagaa  tttcgaagt  agaccatca  tgaggaaga  540
ctggtgggg  tcatgaaca  gtttataga  gatgcaaag  aaggagtcc  tgcgaaaga  600
ggctggccc  atagtgcat  tggggtcac  aagataggg  tgacagtcc  gtccagaat  660
tatgccagg  aactcaatg  ggagaggag  gaggacaag  tcctcctga  tgcctgctg  720
cctgggtgg  tcagaaccg  catgacagg  ccagaagcc  ccaaaagcc  agaagaagg  780
gcagagacc  ccgtgtact  ggccctttt  cctccaggt  cagaggggc  tcacgggca  840
tttgttcaa  ataaaaaag  tgaaccatg  tgaatccaa  tctcacccc  accccttct  900
tcctgactt  gtgaaagcc  agggacatt  ataatatac  atcacttct  gaaaaataa  960
cataactaa  tctttaagc  c  981



<210> 2287
<211> 276
<212> PRT
<213> Rattus norvegicus
<308> P47727
<400> 2287

Ser Ser Asp Arg Pro Val Ala Leu Val Thr Gly Ala Asn Lys Gly Ile 
  1               5                  10                  15
Gly Phe Ala Ile Val Arg Asp Leu Cys Arg Lys Phe Leu Gly Asp Val 
             20                  25                  30
Val Leu Thr Ala Arg Asp Glu Ser Arg Gly His Glu Ala Val Lys Gln 
         35                  40                  45
Leu Gln Thr Glu Gly Leu Ser Pro Arg Phe His Gln Leu Asp Ile Asp 
     50                  55                  60
Asn Pro Gln Ser Ile Arg Ala Leu Arg Asp Phe Leu Leu Gln Glu Tyr 
 65                  70                  75                  80
Gly Gly Leu Asn Val Leu Val Asn Asn Ala Gly Ile Ala Phe Lys Val 
                 85                  90                  95
Val Asp Pro Thr Pro Phe His Ile Gln Ala Glu Val Thr Met Lys Thr 
             100                105                110
Asn Phe Phe Gly Thr Gln Asp Val Cys Lys Glu Leu Leu Pro Ile Ile 
         115                120                125
Lys Pro Gln Gly Arg Val Val Asn Val Ser Ser Ser Val Ser Leu Arg 
     130                135                140
Ala Leu Lys Ser Cys Ser Pro Glu Leu Gln Gln Lys Phe Arg Ser Glu 
 145                150                155                160
Thr Ile Thr Glu Glu Glu Leu Val Gly Leu Met Asn Lys Phe Ile Glu 
                 165                170                175
Asp Ala Lys Lys Gly Val His Ala Lys Glu Gly Trp Pro Asn Ser Ala 
             180                185                190
Tyr Gly Val Thr Lys Ile Gly Val Thr Val Leu Ser Arg Ile Tyr Ala 
         195                200                205
Arg Lys Leu Asn Glu Glu Arg Arg Glu Asp Lys Ile Leu Leu Asn Ala 
     210                215                220
Cys Cys Pro Gly Trp Val Arg Thr Asp Met Ala Gly Pro Lys Ala Thr 
 225                230                235                240
Lys Ser Pro Glu Glu Gly Ala Glu Thr Pro Val Tyr Leu Ala Leu Leu 
                 245                250                255
Pro Pro Gly Ala Glu Gly Pro His Gly Gln Phe Val Gln Asp Lys Lys 
             260                265                270
Val Glu Pro Trp 
         275



<210> 2288
<211> 1209
<212> DNA
<213> Homo sapiens
<308> J04056
<400> 2288

cagactcga  cagtctctg  aacacgctg  ggggctccc  ggcctgagc  aggtctgtt  60
tccacgcag  tgttccgcg  gccccgttc  gccatgtcg  ccggcatcc  tgtagcgct  120
gtgactgga  gcaacaagg  catcggctt  gccatcgtg  gcgacctgt  ccggctgtt  180
tcgggggac  tggtgctca  ggcgcggga  gtgacgcgg  gccaggcgg  cgtacagca  240
ctgcaggcg  agggcctga  cccgcgctt  caccagctg  acatcgacg  tctgcagag  300
atccgcgcc  tgcgcgact  cctgcgcaa  gagtacggg  gcctggacg  gctggtcaa  360
aacgcgggc  tcgccttca  ggttgctga  cccacaccc  ttcatattc  agctgaagt  420
acgatgaaa  caaatttct  tggtacccg  gatgtgtgc  cagaattac  ccctctaat  480
aaaccccaa  ggagagtgg  gaacgtatc  agcatcatg  gcgtcagag  ccttaaaag  540
tgcagccca  agctgcagc  gaagttccg  agtgagacc  tcactgagg  ggagctggt  600
gggctcatg  acaagtttg  ggaggatac  aagaaggga  tgcaccaga  ggagggctg  660
cccagcagc  catacgggg  gacgaagat  ggcgtcacc  ttctgtcca  gatccacgc  720
aggaaactg  gtgagcaga  gaaagggga  aagatcctc  tgaatgcct  ctgcccagg  780
tgggtgaga  ctgacatgg  gggacccaa  gccaccaag  gcccagaag  aggtgcaga  840
acccctgtg  acttggccc  tttgccccc  gatgctgag  gtccccatg  acaatttgt  900
tcagagaag  gagttgaac  gtggtgagc  gggctcaca  ctccatcca  gggccccat  960
ttgtacctt  tcctgagtt  gtccaaagg  catttacaa  gtcataaat  tccttatat  1020
agaaaaaaa  tgatctctt  tcaattagc  ctcactaat  tactactaa  tgagcaacc  1080
acgcactca  ttgactacg  aaatctgtc  ggtcttttg  gatttcctc  gatgcagga  1140
aggaaaaat  gtaattgat  aaaataatg  atgaaaatc  acagatgaa  aaatggttc  1200
ttataagtg  1209



<210> 2289
<211> 276
<212> PRT
<213> Homo sapiens
<308> P16152
<400> 2289

Ser Ser Gly Ile His Val Ala Leu Val Thr Gly Gly Asn Lys Gly Ile 
  1               5                  10                  15
Gly Leu Ala Ile Val Arg Asp Leu Cys Arg Leu Phe Ser Gly Asp Val 
             20                  25                  30
Val Leu Thr Ala Arg Asp Val Thr Arg Gly Gln Ala Ala Val Gln Gln 
         35                  40                  45
Leu Gln Ala Glu Gly Leu Ser Pro Arg Phe His Gln Leu Asp Ile Asp 
     50                  55                  60
Asp Leu Gln Ser Ile Arg Ala Leu Arg Asp Phe Leu Arg Lys Glu Tyr 
 65                  70                  75                  80
Gly Gly Leu Asp Val Leu Val Asn Asn Ala Gly Ile Ala Phe Lys Val 
                 85                  90                  95
Ala Asp Pro Thr Pro Phe His Ile Gln Ala Glu Val Thr Met Lys Thr 
             100                105                110
Asn Phe Phe Gly Thr Arg Asp Val Cys Thr Glu Leu Leu Pro Leu Ile 
         115                120                125
Lys Pro Gln Gly Arg Val Val Asn Val Ser Ser Ile Met Ser Val Arg 
     130                135                140
Ala Leu Lys Ser Cys Ser Pro Glu Leu Gln Gln Lys Phe Arg Ser Glu 
 145                150                155                160
Thr Ile Thr Glu Glu Glu Leu Val Gly Leu Met Asn Lys Phe Val Glu 
                 165                170                175
Asp Thr Lys Lys Gly Val His Gln Lys Glu Gly Trp Pro Ser Ser Ala 
             180                185                190
Tyr Gly Val Thr Lys Ile Gly Val Thr Val Leu Ser Arg Ile His Ala 
         195                200                205
Arg Lys Leu Ser Glu Gln Arg Lys Gly Asp Lys Ile Leu Leu Asn Ala 
     210                215                220
Cys Cys Pro Gly Trp Val Arg Thr Asp Met Ala Gly Pro Lys Ala Thr 
 225                230                235                240
Lys Ser Pro Glu Glu Gly Ala Glu Thr Pro Val Tyr Leu Ala Leu Leu 
                 245                250                255
Pro Pro Asp Ala Glu Gly Pro His Gly Gln Phe Val Ser Glu Lys Arg 
             260                265                270
Val Glu Gln Trp 
         275



<210> 2290
<211> 2632
<212> DNA
<213> Rattus norvegicus
<308> D89340
<400> 2290

ctgcagcag  gctcatggc  gatacccag  acatcctgc  caatgacat  ggtgtgtct  60
gcctggact  ccgggaggc  ttccgcctg  tgtcaccca  agagcgcct  tatgcccat  120
acctgtcta  agccgcttg  tatggaggc  tggctgtgc  gctccagac  tctcctgaa  180
ccccctaca  ctatgccct  cttagccgc  tcttccgtg  ccaggaccc  gaccagcta  240
gccaacatg  cctggctga  ggcctgact  aagaagagt  tcaggcatt  ctggtctac  300
ctgcagggg  ctactccaa  atgggcaac  ataagtcct  cggtgacac  aagtttgtc  360
ctaacctgc  caaggaaaa  ctggagcgt  tgatccttg  gagtaaggc  gcccaacag  420
atccagaag  agtcaggag  ctttggcag  cctgtgggg  gcttatgtt  tccctggaa  480
caaggcttc  acatcttgg  ctggggaag  agggagtca  cacctattt  tctggggat  540
gtgccatgg  agatgccaa  ctggcccag  acttcctgg  ctctcagaa  ctcagtgca  600
acaacaccc  gctcttcaa  gtggtcggc  aggaaggga  gtaccacta  gaggtgcga  660
tggcttcag  actcaacac  gaacctgct  tcgactctg  gttgacttc  aagctgaag  720
gctacgagt  ccaggggaa  catttccag  tcacccgtg  ggactatgc  cccatcctc  780
agaaggtgg  agaacactt  gagaaagct  aggcttatg  agccaatag  caccaggag  840
aaatgctgg  ccagtatgt  gagagcttc  cccagggtt  cattgaggc  cataagagg  900
gctcccgct  ctggattca  gacaaaggt  ccattgtag  gagttacat  ggcttcatt  960
agagctacc  tgacccctt  ggctcccga  gagaatttg  aggcttcgt  gccatggta  1020
acaaagaca  gagtgcaaa  ttcgagcgg  tggttgcaa  tgctgagca  ctgctgaag  1080
agctgcctt  gcctcctgc  tttgagaag  acaagttcc  cacccctga  ttcacttcc  1140
tggatgtcc  tacctttgc  ggctctggc  tccctgcag  catcaacat  cccaactat  1200
atgacctga  acagacaga  ggctttaag  atgtgtctc  ggggaatgt  ctggctgtg  1260
cctatgcca  aaagcggga  aaactcacc  tcatggagg  agaagacaa  gacctgtac  1320
tccgctgga  ggggccgtc  tttgatgtg  aggtggggt  acatgagct  ttgggccat  1380
gcagcggca  gctctttgt  caggatgag  aaggtgctt  caactttga  caggagaca  1440
tgatcaacc  agagactgg  gagcagatc  agagctggt  ccggagtgg  gagacatgg  1500
atagcaaat  tagcaccat  gcctccagc  acgaagagt  ccgggctga  agcgtgggc  1560
tctacctct  tctcaaccc  caagtactt  agatctttg  ctttgaggg  actgacgca  1620
aagatgtca  ctatgtgaa  tggctcaac  tggtccggg  tgggctgtt  gctttggag  1680
tctacaccc  agagacggc  aactggcga  aggcccaca  gcaggcccg  tttgtgatc  1740
tgagggttt  gctggaagc  ggcgaagga  tcgttaccg  cacccccac  acaggctct  1800
atgggcgcc  agatgctcg  gtccacctg  accgcagca  gatccggtc  gtgggcaaa  1860
ctgctttgg  gcggttcct  cggagactg  aggtgctga  gtccacagg  gatgtggtt  1920
cagggcgcg  cctgtacga  ggctatgcg  cggtcactg  cgcaccccc  gagtgcttc  1980
tcactctaa  ggacacggt  ttgctgcgc  aggaatccc  gaagcttat  gtccagccc  2040
acactcgcc  ggaaggctc  gaagtgcaa  ttgtagagt  tgaggcctc  gcggctggt  2100
tcatccgat  cttctgtga  cggtttccg  aggatgggc  tgagttgga  gaggttctt  2160
cccagctgg  cacagcaga  gctcaattc  ggagggatc  ggtccagga  gccccatct  2220
gccaggctt  agaagatct  tgtggcatc  cccctttca  caaaccagg  ctgtctgtg  2280
ccctgaatt  tgtttagga  gtgggggaa  ggcaggagc  cggactttg  tgctacctc  2340
gctgagggt  gtgatgcta  ccccttcca  ttgtcagca  tttccagtt  accattatg  2400
cctcatttc  tggatctgc  ctgccatct  tggtgggag  tcaacaggg  gcctagtct  2460
gttttccaa  tgggaaggt  gcagttctg  gaagtaact  ttctagatc  agcaggtgg  2520
atgtgacag  gccagggct  aaagcattc  caccaaatc  agtgctctt  gtgtattac  2580
ttttatagc  agaaaaata  atatgacaa  caccaaaaa  aaaaaaaaa  aa  2632



<210> 2291
<211> 738
<212> PRT
<213> Rattus norvegicus
<308> O55096
<400> 2291

Met Ala Asp Thr Gln Tyr Ile Leu Pro Asn Asp Ile Gly Val Ser Ser 
  1               5                  10                  15
Leu Asp Cys Arg Glu Ala Phe Arg Leu Leu Ser Pro Thr Glu Arg Leu 
             20                  25                  30
Tyr Ala His His Leu Ser Arg Ala Ala Trp Tyr Gly Gly Leu Ala Val 
         35                  40                  45
Leu Leu Gln Thr Ser Pro Glu Ala Pro Tyr Ile Tyr Ala Leu Leu Ser 
     50                  55                  60
Arg Leu Phe Arg Ala Gln Asp Pro Asp Gln Leu Arg Gln His Ala Leu 
 65                  70                  75                  80
Ala Glu Gly Leu Thr Glu Glu Glu Tyr Gln Ala Phe Leu Val Tyr Ala 
                 85                  90                  95
Ala Gly Val Tyr Ser Asn Met Gly Asn Tyr Lys Ser Phe Gly Asp Thr 
             100                105                110
Lys Phe Val Pro Asn Leu Pro Lys Glu Lys Leu Glu Arg Val Ile Leu 
         115                120                125
Gly Ser Lys Ala Ala Gln Gln His Pro Glu Glu Val Arg Ser Leu Trp 
     130                135                140
Gln Thr Cys Gly Glu Leu Met Phe Ser Leu Glu Pro Arg Leu Arg His 
 145                150                155                160
Leu Gly Leu Gly Lys Glu Gly Val Thr Thr Tyr Phe Ser Gly Asp Cys 
                 165                170                175
Ala Met Glu Asp Ala Lys Leu Ala Gln Asp Phe Leu Asp Ser Gln Asn 
             180                185                190
Leu Ser Ala Tyr Asn Thr Arg Leu Phe Lys Val Val Gly Gln Glu Gly 
         195                200                205
Lys Tyr His Tyr Glu Val Arg Leu Ala Ser Val Leu Asn Thr Glu Pro 
     210                215                220
Ala Leu Asp Ser Glu Leu Thr Ser Lys Leu Lys Ser Tyr Glu Phe Gln 
 225                230                235                240
Gly Asn His Phe Gln Val Thr Arg Gly Asp Tyr Ala Pro Ile Leu Gln 
                 245                250                255
Lys Val Val Glu His Leu Glu Lys Ala Lys Ala Tyr Ala Ala Asn Ser 
             260                265                270
His Gln Glu Gln Met Leu Ala Gln Tyr Val Glu Ser Phe Thr Gln Gly 
         275                280                285
Ser Ile Glu Ala His Lys Arg Gly Ser Arg Phe Trp Ile Gln Asp Lys 
     290                295                300
Gly Pro Ile Val Glu Ser Tyr Ile Gly Phe Ile Glu Ser Tyr Arg Asp 
 305                310                315                320
Pro Phe Gly Ser Arg Gly Glu Phe Glu Gly Phe Val Ala Met Val Asn 
                 325                330                335
Lys Asp Met Ser Ala Lys Phe Glu Arg Leu Val Ala Ser Ala Glu Gln 
             340                345                350
Leu Leu Lys Glu Leu Pro Trp Pro Pro Ala Phe Glu Lys Asp Lys Phe 
         355                360                365
Leu Thr Pro Asp Phe Thr Ser Leu Asp Val Leu Thr Phe Ala Gly Ser 
     370                375                380
Gly Ile Pro Ala Gly Ile Asn Ile Pro Asn Tyr Asp Asp Leu Arg Gln 
 385                390                395                400
Thr Glu Gly Phe Lys Asn Val Ser Leu Gly Asn Val Leu Ala Val Ala 
                 405                410                415
Tyr Ala Thr Lys Arg Glu Lys Leu Thr Phe Met Glu Glu Glu Asp Lys 
             420                425                430
Asp Leu Tyr Ile Arg Trp Lys Gly Pro Ser Phe Asp Val Gln Val Gly 
         435                440                445
Leu His Glu Leu Leu Gly His Gly Ser Gly Lys Leu Phe Val Gln Asp 
     450                455                460
Glu Lys Gly Ala Phe Asn Phe Asp Gln Glu Thr Val Ile Asn Pro Glu 
 465                470                475                480
Thr Gly Glu Gln Ile Gln Ser Trp Tyr Arg Ser Gly Glu Thr Trp Asp 
                 485                490                495
Ser Lys Phe Ser Thr Ile Ala Ser Ser Tyr Glu Glu Cys Arg Ala Glu 
             500                505                510
Ser Val Gly Leu Tyr Leu Cys Leu Asn Pro Gln Val Leu Gln Ile Phe 
         515                520                525
Gly Phe Glu Gly Thr Asp Ala Glu Asp Val Ile Tyr Val Asn Trp Leu 
     530                535                540
Asn Met Val Arg Ala Gly Leu Leu Ala Leu Glu Phe Tyr Thr Pro Glu 
 545                550                555                560
Thr Ala Asn Trp Arg Gln Ala His Met Gln Ala Arg Phe Val Ile Leu 
                 565                570                575
Arg Val Leu Leu Glu Ala Gly Glu Gly Leu Val Thr Val Thr Pro Thr 
             580                585                590
Thr Gly Ser Asp Gly Arg Pro Asp Ala Arg Val His Leu Asp Arg Ser 
         595                600                605
Lys Ile Arg Ser Val Gly Lys Pro Ala Leu Glu Arg Phe Leu Arg Arg 
     610                615                620
Leu Gln Val Leu Lys Ser Thr Gly Asp Val Val Ala Gly Arg Ala Leu 
 625                630                635                640
Tyr Glu Gly Tyr Ala Ala Val Thr Asp Ala Pro Pro Glu Cys Phe Leu 
                 645                650                655
Thr Leu Arg Asp Thr Val Leu Leu Arg Lys Glu Ser Arg Lys Leu Ile 
             660                665                670
Val Gln Pro Asn Thr Arg Leu Glu Gly Ser Glu Val Gln Leu Val Glu 
         675                680                685
Tyr Glu Ala Ser Ala Ala Gly Leu Ile Arg Ser Phe Cys Glu Arg Phe 
     690                695                700
Pro Glu Asp Gly Pro Glu Leu Glu Glu Val Leu Thr Gln Leu Ala Thr 
 705                710                715                720
Ala Asp Ala Gln Phe Trp Arg Asp Gln Val Gln Glu Ala Pro Ser Gly 
                 725                730                735
Gln Ala 
             740



<210> 2292
<211> 1292
<212> DNA
<213> Homo sapiens
<308> AK021449
<400> 2292

gagtctgcg  acggagcag  tgctgcagc  gggcccatg  cggacaccc  gtacatcct  60
cccaatgac  tcggcgtgt  tagcctgga  tgccgtgag  ccttccgcc  gctgtcacc  120
acagagcgc  tctatgcct  ccacctgtc  cgtgccgcc  ggtacggag  cctggctgt  180
ctgcttcag  cctcccctg  ggcccccta  atctatgct  tgctcagcc  cctcttccg  240
gcccaggac  ccgaccagc  gcgccaaca  gccctggct  aaggcctta  cgaggagga  300
tatcaggcg  tcctggtct  tgccgcggg  gtttactcc  acatgggca  ctacaagtc  360
tttggtgac  ccaagtttg  tcccaactt  cccaaggaa  agctggaac  ggtgatcct  420
gggagtgag  ctgctcagc  gcacccaga  gaagtcagg  gcctctggc  gacctgcgg  480
gagcttatg  tctctctgg  gccaaggct  cgacacctc  gactgggga  ggagggaat  540
accacctat  tctctggga  ttgtaccat  gaagatgcc  gggtccgcc  cgaccgcag  600
aagatccgg  ctgtgggca  gcctgctct  gagcgcttc  tgcggagac  tcaggtgct  660
aagtccaca  gggatgtgg  cggagggcg  gccctgtac  aggggtatg  aacagtcac  720
gatgcgccc  ccgagtgct  cctcaccct  agggacacg  tgctgctgc  taaggaatc  780
cggaagctc  ttgttcagc  caacactcg  cttgaaggc  cagacgtgc  gcttctgga  840
tacgaggcg  cagctgctg  cctcatccg  tccttctct  agcgtttcc  agaggatgg  900
cccgagttg  aggagatcc  cacacagct  gccacagcc  atgcccgat  ctggaaggg  960
cccagtgag  ccccatctg  ccaagcttg  ggaagatgt  tggccttgc  cccaattcc  1020
tcagaccaa  gctgcaagt  gccctccat  cgtcacttt  cagcctgcc  attgcttcc  1080
ctctgtgat  tcatttcat  tgcactgcc  tacgtggag  gagcaagac  gggcttacc  1140
tcctgtcta  cagatgagg  aatggcagt  ctgagaagt  actggtcta  atcccgcag  1200
tggcacgtg  cagctaggg  tcaaaacgt  ctcaccaaa  ccaatgctc  tcacatatt  1260
attttataa  cagacaaat  aatattaga  ac  1292



<210> 2293
<211> 737
<212> PRT
<213> Homo sapiens
<308> Q9NY33
<400> 2293

Met Ala Asp Thr Gln Tyr Ile Leu Pro Asn Asp Ile Gly Val Ser Ser 
  1               5                  10                  15
Leu Asp Cys Arg Glu Ala Phe Arg Leu Leu Ser Pro Thr Glu Arg Leu 
             20                  25                  30
Tyr Ala Tyr His Leu Ser Arg Ala Ala Trp Tyr Gly Gly Leu Ala Val 
         35                  40                  45
Leu Leu Gln Thr Ser Pro Glu Ala Pro Tyr Ile Tyr Ala Leu Leu Ser 
     50                  55                  60
Arg Leu Phe Arg Ala Gln Asp Pro Asp Gln Leu Arg Gln His Ala Leu 
 65                  70                  75                  80
Ala Glu Gly Leu Thr Glu Glu Glu Tyr Gln Ala Phe Leu Val Tyr Ala 
                 85                  90                  95
Ala Gly Val Tyr Ser Asn Met Gly Asn Tyr Lys Ser Phe Gly Asp Thr 
             100                105                110
Lys Phe Val Pro Asn Leu Pro Lys Glu Lys Leu Glu Arg Val Ile Leu 
         115                120                125
Gly Ser Glu Ala Ala Gln Gln His Pro Glu Glu Val Arg Gly Leu Trp 
     130                135                140
Gln Thr Cys Gly Glu Leu Met Phe Ser Leu Glu Pro Arg Leu Arg His 
 145                150                155                160
Leu Gly Leu Gly Lys Glu Gly Ile Thr Thr Tyr Phe Ser Gly Asn Cys 
                 165                170                175
Thr Met Glu Asp Ala Lys Leu Ala Gln Asp Phe Leu Asp Ser Gln Asn 
             180                185                190
Leu Ser Ala Tyr Asn Thr Arg Leu Phe Lys Glu Val Asp Gly Glu Gly 
         195                200                205
Lys Pro Tyr Tyr Glu Val Arg Leu Ala Ser Val Leu Gly Ser Glu Pro 
     210                215                220
Ser Leu Asp Ser Glu Val Thr Ser Lys Leu Lys Ser Tyr Glu Phe Arg 
 225                230                235                240
Gly Ser Pro Phe Gln Val Thr Arg Gly Asp Tyr Ala Pro Ile Leu Gln 
                 245                250                255
Lys Val Val Glu Gln Leu Glu Lys Ala Lys Ala Tyr Ala Ala Asn Ser 
             260                265                270
His Gln Gly Gln Met Leu Ala Gln Tyr Ile Glu Ser Phe Thr Gln Gly 
         275                280                285
Ser Ile Glu Ala His Lys Arg Gly Ser Arg Phe Trp Ile Gln Asp Lys 
     290                295                300
Gly Pro Ile Val Glu Ser Tyr Ile Gly Phe Ile Glu Ser Tyr Arg Asp 
 305                310                315                320
Pro Phe Gly Ser Arg Gly Glu Phe Glu Gly Phe Val Ala Val Val Asn 
                 325                330                335
Lys Ala Met Ser Ala Lys Phe Glu Arg Leu Val Ala Ser Ala Glu Gln 
             340                345                350
Leu Leu Lys Glu Leu Pro Trp Pro Pro Thr Phe Glu Lys Asp Lys Phe 
         355                360                365
Leu Thr Pro Asp Phe Thr Ser Leu Asp Val Leu Thr Phe Ala Gly Ser 
     370                375                380
Gly Ile Pro Ala Gly Ile Asn Ile Pro Asn Tyr Asp Asp Leu Arg Gln 
 385                390                395                400
Thr Glu Gly Phe Lys Asn Val Ser Leu Gly Asn Val Leu Ala Val Ala 
                 405                410                415
Tyr Ala Thr Gln Arg Glu Lys Leu Thr Phe Leu Glu Glu Asp Asp Lys 
             420                425                430
Asp Leu Tyr Ile Leu Trp Lys Gly Pro Ser Phe Asp Val Gln Val Gly 
         435                440                445
Leu His Glu Leu Leu Gly His Gly Ser Gly Lys Leu Phe Val Gln Asp 
     450                455                460
Glu Lys Gly Ala Phe Asn Phe Asp Gln Glu Thr Val Ile Asn Pro Glu 
 465                470                475                480
Thr Gly Glu Gln Ile Gln Ser Trp Tyr Arg Ser Gly Glu Thr Trp Asp 
                 485                490                495
Ser Lys Phe Ser Thr Ile Ala Ser Ser Tyr Glu Glu Cys Arg Ala Glu 
             500                505                510
Ser Val Gly Leu Tyr Leu Cys Leu His Pro Gln Val Leu Glu Ile Phe 
         515                520                525
Gly Phe Glu Gly Ala Asp Ala Glu Asp Val Ile Tyr Val Asn Trp Leu 
     530                535                540
Asn Met Val Arg Ala Gly Leu Leu Ala Leu Glu Phe Tyr Thr Pro Glu 
 545                550                555                560
Ala Phe Asn Trp Arg Gln Ala His Met Gln Ala Arg Phe Val Ile Leu 
                 565                570                575
Arg Val Leu Leu Glu Ala Gly Glu Gly Leu Val Thr Ile Thr Pro Thr 
             580                585                590
Thr Gly Ser Asp Gly Arg Pro Asp Ala Arg Val Arg Leu Asp Arg Ser 
         595                600                605
Lys Ile Arg Ser Val Gly Lys Pro Ala Leu Glu Arg Phe Leu Arg Arg 
     610                615                620
Leu Gln Val Leu Lys Ser Thr Gly Asp Val Ala Gly Gly Arg Ala Leu 
 625                630                635                640
Tyr Glu Gly Tyr Ala Thr Val Thr Asp Ala Pro Pro Glu Cys Phe Leu 
                 645                650                655
Thr Leu Arg Asp Thr Val Leu Leu Arg Lys Glu Ser Arg Lys Leu Ile 
             660                665                670
Val Gln Pro Asn Thr Arg Leu Glu Gly Ser Asp Val Gln Leu Leu Glu 
         675                680                685
Tyr Glu Ala Ser Ala Ala Gly Leu Ile Arg Ser Phe Ser Glu Arg Phe 
     690                695                700
Pro Glu Asp Gly Pro Glu Leu Glu Glu Ile Leu Thr Gln Leu Ala Thr 
 705                710                715                720
Ala Asp Ala Arg Phe Trp Lys Gly Pro Ser Glu Ala Pro Ser Gly Gln 
                 725                730                735
Ala 
             740



<210> 2294
<211> 2392
<212> DNA
<213> Rattus norvegicus
<308> D89655
<400> 2294

gctgccact  tcaggcaca  accttgctg  tcggtttct  tcatctctg  ggcctccgt  60
gcctctgtc  ccgtcccct  caggtcctg  gcccagcga  tctcggccg  gcacgcgga  120
atgggcgtc  gctccaggg  acgctgggt  gccttgggg  tgggcgttc  agggctgct  180
tgtgctgcg  tcggcgtta  catgattct  atggtgccc  cgctcatca  gcagcaggt  240
ctcaagaat  tccgcatag  ccccagcag  ctgtccttt  ggatgtgga  ggagatccc  300
gttcccttc  acttgtccg  ctacttctt  gaggtggtc  accccagcg  ggtcctaaa  360
ggccagaag  cagtagtcc  ggagcgcgg  ccctatgtc  acagggagt  cagacaaaa  420
gttaacatc  ccttcaatg  caatgacac  gtgtcctac  tagagaacc  aagccttcg  480
ttccagcca  acaggtccc  gggctcaga  agtgactac  ttgtactgc  taacatcct  540
gtcctggga  gggcagtga  gatggagga  aagcccaca  gcctgaagc  gctaatgac  600
ttggggttg  tcaccatgg  ccagcgggc  tttatgaac  gcacggttg  tgagatcct  660
tggggctac  aagatccct  tgtgaattt  ctcagcaaa  atttcccag  catgttccc  720
atcaaaggc  aatttggcc  gttcgttgg  atgaacgac  cgagttctg  cgtcttcac  780
gtcttcaca  gtgtccaga  tttcagcaa  atccatctg  tggataagt  gaacggcct  840
agcgaggtc  actattggc  ttcggaaca  tgcaacatg  tcaatggta  tgccgggca  900
atgtgggca  cattcatga  acccgaatc  tcactggaa  tcttcagcc  agaagcctg  960
agatctatg  agctcacct  ccaggaatc  agggtgttc  aaggcatcc  cacttatcg  1020
ttcacggcc  ccgatactt  gtttgccaa  gggtccgtc  acccaccta  tgaaggctt  1080
tgcccgtgc  gcgagtccg  cattcagaa  gtcagcacc  gcaggtttg  tgcgcccct  1140
tttctctcc  agccccact  ctacaatgc  gaccccgtg  tgtcagaag  tgttcttgg  1200
ctgaaccct  acccaaagg  gcattcctt  ttcctagac  tccacccgg  cactgggat  1260
cccatgaac  gttccgtga  gatgcagct  agtctgtac  tcaaatccg  caagggcgt  1320
gggcaaaca  ggaagatcg  gccagtagt  ctgccattg  tgtggttcg  acagagcgg  1380
atgatgggt  gcaagaccc  gaacacgtt  tacacgcag  tggtgctga  gccccaggt  1440
cttcactac  cgcagtatg  gctgctggg  cttggaggc  tcctgcttc  ggtgcccat  1500
atttaccaa  tgcgcagcc  ggagaaatg  tttttattt  ggagtggta  taaaaaggg  1560
tcgcaggat  aggaggcca  gcaggccta  tctgagtct  tgatgtcac  agctgccaa  1620
ggcacggta  tgcaagaag  caagctgta  ggcccagaa  acaccacga  ccccccaaa  1680
ctgatagct  ggtcagacc  gccgcccag  ccctacacc  cacttctcg  ggactctct  1740
agcggacaa  ccgccagtg  cacgtcctg  gcccccaga  gtcacactg  ccccacggc  1800
catagtgtg  ggaaacact  agggaccag  gacagaccc  ctgctgagt  gagcctgtt  1860
ggccacagg  gacctcttc  aagtgacct  tgagccagg  tgtgggaac  gtagctgcc  1920
ctcctgtag  agctggcgc  gccgggctc  tgactttct  cgtctttct  cagcaggct  1980
aaagcctta  ttcccacag  ggacacaga  ctgtcactc  taggggctg  gcaaacatc  2040
gcctcttgc  tcacggctg  acaagcagt  ccagatcct  accagtctg  acacacact  2100
tggcgctgt  tctggccct  ctcctacag  ctctgctgt  acctgaaca  tgaattggc  2160
actgtaagt  gcagcggtg  caggccccc  cagggtcct  atttttcag  cgtggggtc  2220
aagagagag  tgtgggccg  ctacccctg  cacctagta  atctcacca  agggtaggg  2280
atacagagg  ccagcgtcc  acaatcgac  ccttttttt  ctactggaa  agaaatttt  2340
tcgtctttt  aaagaaagt  atgactgaa  caataaacc  tttcacaaa  ta  2392



<210> 2295
<211> 510
<212> PRT
<213> Rattus norvegicus
<308> D89655
<400> 2295

Met Gly Val Ser Ser Arg Ala Arg Trp Val Ala Leu Gly Leu Gly Val 
  1               5                  10                  15
Leu Gly Leu Leu Cys Ala Ala Leu Gly Val Ile Met Ile Leu Met Val 
             20                  25                  30
Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
         35                  40                  45
Ser Ser Leu Ser Phe Gly Met Trp Lys Glu Ile Pro Val Pro Phe Tyr 
     50                  55                  60
Leu Ser Val Tyr Phe Phe Glu Val Val Asn Pro Ser Glu Val Leu Asn 
 65                  70                  75                  80
Gly Gln Lys Pro Val Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                 85                  90                  95
Phe Arg Gln Lys Val Asn Ile Thr Phe Asn Asp Asn Asp Thr Val Ser 
             100                105                110
Tyr Ile Glu Asn Arg Ser Leu Arg Phe Gln Pro Asp Arg Ser Gln Gly 
         115                120                125
Ser Glu Ser Asp Tyr Ile Val Leu Pro Asn Ile Leu Val Leu Gly Gly 
     130                135                140
Ala Val Met Met Glu Asp Lys Pro Thr Ser Leu Lys Leu Leu Met Thr 
 145                150                155                160
Leu Gly Leu Val Thr Met Gly Gln Arg Ala Phe Met Asn Arg Thr Val 
                 165                170                175
Gly Glu Ile Leu Trp Gly Tyr Glu Asp Pro Phe Val Asn Phe Leu Ser 
             180                185                190
Lys Tyr Phe Pro Asp Met Phe Pro Ile Lys Gly Lys Phe Gly Leu Phe 
         195                200                205
Val Gly Met Asn Asp Ser Ser Ser Gly Val Phe Thr Val Phe Thr Gly 
     210                215                220
Val Gln Asn Phe Ser Lys Ile His Leu Val Asp Lys Trp Asn Gly Leu 
 225                230                235                240
Ser Glu Val Asn Tyr Trp His Ser Glu Gln Cys Asn Met Ile Asn Gly 
                 245                250                255
Thr Ala Gly Gln Met Trp Ala Pro Phe Met Thr Pro Glu Ser Ser Leu 
             260                265                270
Glu Phe Phe Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Thr Tyr Gln 
         275                280                285
Glu Ser Arg Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Thr Ala Pro 
     290                295                300
Asp Thr Leu Phe Ala Asn Gly Ser Val Tyr Pro Pro Asn Glu Gly Phe 
 305                310                315                320
Cys Pro Cys Arg Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                 325                330                335
Gly Ala Pro Leu Phe Leu Ser Gln Pro His Phe Tyr Asn Ala Asp Pro 
             340                345                350
Val Leu Ser Glu Ala Val Leu Gly Leu Asn Pro Asp Pro Lys Glu His 
         355                360                365
Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
     370                375                380
Ser Val Lys Met Gln Leu Ser Leu Tyr Ile Lys Ser Val Lys Gly Val 
 385                390                395                400
Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                 405                410                415
Glu Gln Ser Gly Met Met Gly Gly Lys Thr Leu Asn Thr Phe Tyr Thr 
             420                425                430
Gln Leu Val Leu Met Pro Gln Val Leu His Tyr Ala Gln Tyr Val Leu 
         435                440                445
Leu Gly Leu Gly Gly Leu Leu Leu Leu Val Pro Ile Ile Tyr Gln Leu 
     450                455                460
Arg Ser Gln Glu Lys Cys Phe Leu Phe Trp Ser Gly Ser Lys Lys Gly 
 465                470                475                480
Ser Gln Asp Lys Glu Ala Met Gln Ala Tyr Ser Glu Ser Leu Met Ser 
                 485                490                495
Pro Ala Ala Lys Gly Thr Val Leu Gln Glu Ala Lys Leu Ter 
             500                505                510



<210> 2296
<211> 2566
<212> DNA
<213> Homo sapiens
<308> Z22555
<400> 2296

cgtcgccgt  cccgtctcc  gccaggcgc  gagccctgc  agccgcggg  gggccccag  60
cgcgcagac  tgggctgct  cgccaaagc  cgctgggct  ccggggcgc  gggcgtcgc  120
gggctactg  gcgctgtgc  gggcgctgt  atgatcgtg  tggtgccgt  gctcatcaa  180
cagcaggtc  ttaagaacg  gcgcatcga  cccagtagc  tgtccttca  catgtggaa  240
gagatccct  tccccttct  tctctccgt  tacttcttt  acgtcatga  ccccagcga  300
atcctgaag  gcgagaagc  gcaggtgcg  gagcgcggg  cctacgtgt  cagggagtc  360
aggcacaaa  gcaacatca  cttcaacaa  aacgacacc  tgtccttcc  cgagtaccg  420
accttccag  tccagccct  caagtccca  ggctcggag  gcgactaca  cgtcatgcc  480
aacatcctg  tcttgggtg  ggcggtgat  atggagaat  agcccatga  cctgaagct  540
atcatgacc  tggcattca  caccctcgg  gaacgtgcc  tcatgaacc  cactgtggg  600
gagatcatg  ggggctaca  ggaccccct  gtgaatctc  tcaacaagt  ctttccagg  660
atgttcccc  tcaaggaca  gttcggatt  tttgctgag  tcaacaact  cgactctgg  720
ctcttcacg  tgttcacgg  ggtccagaa  atcagcagg  tccacctcg  ggacaagtg  780
aacgggctg  gcaaggttg  cttctggca  tccgatcag  gcaacatga  caatggaac  840
tctgggcaa  tgtggccgc  cttcatgac  cctgagtcc  cgctggagt  ctacagccc  900
gaggcctgc  gatccatga  gctaatgta  aaggagtca  gggtgtttg  aggcatccc  960
acctatcgc  tcgtggctc  caaaaccct  tttgccaac  ggtccatct  cccacccaa  1020
gaaggcttc  gcccgtgcc  ggagtctgg  attcagaac  tcagcacct  caggttcag  1080
gcccccttg  ttctctccc  tcctcactt  ctcaacgcc  acccggttc  ggcagaagc  1140
gtgactggc  tgcacccta  ccaggaggc  cactccttg  tcctggaca  ccacccggt  1200
acgggaatc  ccatgaact  ctctgtgaa  ctgcagctg  gcctctaca  gaaatctgt  1260
gcaggcatt  gacaaactg  gaagattga  cctgtggtc  tgccgctgc  ctggtttgc  1320
gagagcggg  ccatggagg  ggagactct  cacacattc  acactcagc  ggtgttgat  1380
cccaaggtg  tgcactatg  ccagtacgt  ctcctggcg  tgggctgcg  cctgctgct  1440
gtccctgtc  tctgccaaa  ccggagcca  gagaaatgc  atttatttt  gagtagtag  1500
aaaaagggc  caaaggata  ggaggccat  caggcctat  ctgaatccc  gatgacatc  1560
gctcccaag  gctctgtgc  gcaggaagc  aaactgtag  gtcctgagg  caccgtgag  1620
cagccaggc  tggccgctg  gcctgaccg  ccccccagc  cctacaccc  gcttctccc  1680
gactctccc  gcagacagc  ccccagccc  acagcctga  cctcccagc  gccatgtgc  1740
tgttgcaca  ctgcacaca  gccctggca  acatacaca  atgcgtgca  gcttgtgca  1800
acactcagg  atggagctg  tgctgaagg  acttgtagg  agaggctcg  caacaagca  1860
tgttctgga  ccttctctc  acgtggccc  caggctgac  acaggggct  tgggtcctg  1920
gtccccttc  tcgggtgag  ctggcctgt  ccgttcagc  gttgggcca  gcttcctcc  1980
ctccaaggt  aaacactgc  gtcccggtg  ggtggctcc  catgcagga  gggccaggc  2040
gggagtgcc  ccttcctgt  ccaaattca  tggggactc  gtgcccagg  cctggcacg  2100
gctttggcc  tggtctacc  gccaggcca  gcaaagcgc  tttacacag  cctcggaaa  2160
caatggagt  agcacaaga  gccctgtgc  gctgcccga  ggtctccgc  caccccggc  2220
ggactttga  ccccccgaa  tcttcacag  cactgcatc  ggttgtctg  cgccctttt  2280
ctccagcct  aactgacat  atcctatgg  ctgagccgg  cactctctg  ccgaagtgg  2340
gcaggctgt  cccccgagc  gcccccacc  cctcacagg  tccctcaga  tataggtgc  2400
caggctgag  tgaagaggc  tgggggccc  gccttccgg  cgctcctgg  ccctggggc  2460
aacctgtga  ccttttcta  tggaataga  atgagtttt  tcatctttg  aaaataatt  2520
actcttgaa  taataaacg  ttaaaaaaa  ggaaaaaaa  aaaaaa  2566



<210> 2297
<211> 510
<212> PRT
<213> Homo sapiens
<308> Z22555
<400> 2297

Met Gly Cys Ser Ala Lys Ala Arg Trp Ala Ala Gly Ala Leu Gly Val 
  1               5                  10                  15
Ala Gly Leu Leu Cys Ala Val Leu Gly Ala Val Met Ile Val Met Val 
             20                  25                  30
Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
         35                  40                  45
Ser Ser Leu Ser Phe Asn Met Trp Lys Glu Ile Pro Ile Pro Phe Tyr 
     50                  55                  60
Leu Ser Val Tyr Phe Phe Asp Val Met Asn Pro Ser Glu Ile Leu Lys 
 65                  70                  75                  80
Gly Glu Lys Pro Gln Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                 85                  90                  95
Ser Arg His Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp Thr Val Ser 
             100                105                110
Phe Leu Glu Tyr Arg Thr Phe Gln Phe Gln Pro Ser Lys Ser His Gly 
         115                120                125
Ser Glu Ser Asp Tyr Ile Val Met Pro Asn Ile Leu Val Leu Gly Ala 
     130                135                140
Ala Val Met Met Glu Asn Lys Pro Met Thr Leu Lys Leu Ile Met Thr 
 145                150                155                160
Leu Ala Phe Thr Thr Leu Gly Glu Arg Ala Phe Met Asn Arg Thr Val 
                 165                170                175
Gly Glu Ile Met Trp Gly Tyr Lys Asp Pro Leu Val Asn Leu Ile Asn 
             180                185                190
Lys Tyr Phe Pro Gly Met Phe Pro Phe Lys Asp Lys Phe Gly Leu Phe 
         195                200                205
Ala Glu Leu Asn Asn Ser Asp Ser Gly Leu Phe Thr Val Phe Thr Gly 
     210                215                220
Val Gln Asn Ile Ser Arg Ile His Leu Val Asp Lys Trp Asn Gly Leu 
 225                230                235                240
Ser Lys Val Asp Phe Trp His Ser Asp Gln Cys Asn Met Ile Asn Gly 
                 245                250                255
Thr Ser Gly Gln Met Trp Pro Pro Phe Met Thr Pro Glu Ser Ser Leu 
             260                265                270
Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Met Tyr Lys 
         275                280                285
Glu Ser Gly Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Val Ala Pro 
     290                295                300
Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn Glu Gly Phe 
 305                310                315                320
Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                 325                330                335
Ser Ala Pro Leu Phe Leu Ser His Pro His Phe Leu Asn Ala Asp Pro 
             340                345                350
Val Leu Ala Glu Ala Val Thr Gly Leu His Pro Asn Gln Glu Ala His 
         355                360                365
Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
     370                375                380
Ser Val Lys Leu Gln Leu Ser Leu Tyr Met Lys Ser Val Ala Gly Ile 
 385                390                395                400
Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                 405                410                415
Ala Glu Ser Gly Ala Met Glu Gly Glu Thr Leu His Thr Phe Tyr Thr 
             420                425                430
Gln Leu Val Leu Met Pro Lys Val Met His Tyr Ala Gln Tyr Val Leu 
         435                440                445
Leu Ala Leu Gly Cys Val Leu Leu Leu Val Pro Val Ile Cys Gln Ile 
     450                455                460
Arg Ser Gln Glu Lys Cys Tyr Leu Phe Trp Ser Ser Ser Lys Lys Gly 
 465                470                475                480
Ser Lys Asp Lys Glu Ala Ile Gln Ala Tyr Ser Glu Ser Leu Met Thr 
                 485                490                495
Ser Ala Pro Lys Gly Ser Val Leu Gln Glu Ala Lys Leu Ter 
             500                505                510



<210> 2298
<211> 2392
<212> DNA
<213> Rattus norvegicus
<308> D89655
<400> 2298

gctgccact  tcaggcaca  accttgctg  tcggtttct  tcatctctg  ggcctccgt  60
gcctctgtc  ccgtcccct  caggtcctg  gcccagcga  tctcggccg  gcacgcgga  120
atgggcgtc  gctccaggg  acgctgggt  gccttgggg  tgggcgttc  agggctgct  180
tgtgctgcg  tcggcgtta  catgattct  atggtgccc  cgctcatca  gcagcaggt  240
ctcaagaat  tccgcatag  ccccagcag  ctgtccttt  ggatgtgga  ggagatccc  300
gttcccttc  acttgtccg  ctacttctt  gaggtggtc  accccagcg  ggtcctaaa  360
ggccagaag  cagtagtcc  ggagcgcgg  ccctatgtc  acagggagt  cagacaaaa  420
gttaacatc  ccttcaatg  caatgacac  gtgtcctac  tagagaacc  aagccttcg  480
ttccagcca  acaggtccc  gggctcaga  agtgactac  ttgtactgc  taacatcct  540
gtcctggga  gggcagtga  gatggagga  aagcccaca  gcctgaagc  gctaatgac  600
ttggggttg  tcaccatgg  ccagcgggc  tttatgaac  gcacggttg  tgagatcct  660
tggggctac  aagatccct  tgtgaattt  ctcagcaaa  atttcccag  catgttccc  720
atcaaaggc  aatttggcc  gttcgttgg  atgaacgac  cgagttctg  cgtcttcac  780
gtcttcaca  gtgtccaga  tttcagcaa  atccatctg  tggataagt  gaacggcct  840
agcgaggtc  actattggc  ttcggaaca  tgcaacatg  tcaatggta  tgccgggca  900
atgtgggca  cattcatga  acccgaatc  tcactggaa  tcttcagcc  agaagcctg  960
agatctatg  agctcacct  ccaggaatc  agggtgttc  aaggcatcc  cacttatcg  1020
ttcacggcc  ccgatactt  gtttgccaa  gggtccgtc  acccaccta  tgaaggctt  1080
tgcccgtgc  gcgagtccg  cattcagaa  gtcagcacc  gcaggtttg  tgcgcccct  1140
tttctctcc  agccccact  ctacaatgc  gaccccgtg  tgtcagaag  tgttcttgg  1200
ctgaaccct  acccaaagg  gcattcctt  ttcctagac  tccacccgg  cactgggat  1260
cccatgaac  gttccgtga  gatgcagct  agtctgtac  tcaaatccg  caagggcgt  1320
gggcaaaca  ggaagatcg  gccagtagt  ctgccattg  tgtggttcg  acagagcgg  1380
atgatgggt  gcaagaccc  gaacacgtt  tacacgcag  tggtgctga  gccccaggt  1440
cttcactac  cgcagtatg  gctgctggg  cttggaggc  tcctgcttc  ggtgcccat  1500
atttaccaa  tgcgcagcc  ggagaaatg  tttttattt  ggagtggta  taaaaaggg  1560
tcgcaggat  aggaggcca  gcaggccta  tctgagtct  tgatgtcac  agctgccaa  1620
ggcacggta  tgcaagaag  caagctgta  ggcccagaa  acaccacga  ccccccaaa  1680
ctgatagct  ggtcagacc  gccgcccag  ccctacacc  cacttctcg  ggactctct  1740
agcggacaa  ccgccagtg  cacgtcctg  gcccccaga  gtcacactg  ccccacggc  1800
catagtgtg  ggaaacact  agggaccag  gacagaccc  ctgctgagt  gagcctgtt  1860
ggccacagg  gacctcttc  aagtgacct  tgagccagg  tgtgggaac  gtagctgcc  1920
ctcctgtag  agctggcgc  gccgggctc  tgactttct  cgtctttct  cagcaggct  1980
aaagcctta  ttcccacag  ggacacaga  ctgtcactc  taggggctg  gcaaacatc  2040
gcctcttgc  tcacggctg  acaagcagt  ccagatcct  accagtctg  acacacact  2100
tggcgctgt  tctggccct  ctcctacag  ctctgctgt  acctgaaca  tgaattggc  2160
actgtaagt  gcagcggtg  caggccccc  cagggtcct  atttttcag  cgtggggtc  2220
aagagagag  tgtgggccg  ctacccctg  cacctagta  atctcacca  agggtaggg  2280
atacagagg  ccagcgtcc  acaatcgac  ccttttttt  ctactggaa  agaaatttt  2340
tcgtctttt  aaagaaagt  atgactgaa  caataaacc  tttcacaaa  ta  2392



<210> 2299
<211> 510
<212> PRT
<213> Rattus norvegicus
<308> D89655
<400> 2299

Met Gly Val Ser Ser Arg Ala Arg Trp Val Ala Leu Gly Leu Gly Val 
  1               5                  10                  15
Leu Gly Leu Leu Cys Ala Ala Leu Gly Val Ile Met Ile Leu Met Val 
             20                  25                  30
Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
         35                  40                  45
Ser Ser Leu Ser Phe Gly Met Trp Lys Glu Ile Pro Val Pro Phe Tyr 
     50                  55                  60
Leu Ser Val Tyr Phe Phe Glu Val Val Asn Pro Ser Glu Val Leu Asn 
 65                  70                  75                  80
Gly Gln Lys Pro Val Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                 85                  90                  95
Phe Arg Gln Lys Val Asn Ile Thr Phe Asn Asp Asn Asp Thr Val Ser 
             100                105                110
Tyr Ile Glu Asn Arg Ser Leu Arg Phe Gln Pro Asp Arg Ser Gln Gly 
         115                120                125
Ser Glu Ser Asp Tyr Ile Val Leu Pro Asn Ile Leu Val Leu Gly Gly 
     130                135                140
Ala Val Met Met Glu Asp Lys Pro Thr Ser Leu Lys Leu Leu Met Thr 
 145                150                155                160
Leu Gly Leu Val Thr Met Gly Gln Arg Ala Phe Met Asn Arg Thr Val 
                 165                170                175
Gly Glu Ile Leu Trp Gly Tyr Glu Asp Pro Phe Val Asn Phe Leu Ser 
             180                185                190
Lys Tyr Phe Pro Asp Met Phe Pro Ile Lys Gly Lys Phe Gly Leu Phe 
         195                200                205
Val Gly Met Asn Asp Ser Ser Ser Gly Val Phe Thr Val Phe Thr Gly 
     210                215                220
Val Gln Asn Phe Ser Lys Ile His Leu Val Asp Lys Trp Asn Gly Leu 
 225                230                235                240
Ser Glu Val Asn Tyr Trp His Ser Glu Gln Cys Asn Met Ile Asn Gly 
                 245                250                255
Thr Ala Gly Gln Met Trp Ala Pro Phe Met Thr Pro Glu Ser Ser Leu 
             260                265                270
Glu Phe Phe Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Thr Tyr Gln 
         275                280                285
Glu Ser Arg Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Thr Ala Pro 
     290                295                300
Asp Thr Leu Phe Ala Asn Gly Ser Val Tyr Pro Pro Asn Glu Gly Phe 
 305                310                315                320
Cys Pro Cys Arg Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                 325                330                335
Gly Ala Pro Leu Phe Leu Ser Gln Pro His Phe Tyr Asn Ala Asp Pro 
             340                345                350
Val Leu Ser Glu Ala Val Leu Gly Leu Asn Pro Asp Pro Lys Glu His 
         355                360                365
Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
     370                375                380
Ser Val Lys Met Gln Leu Ser Leu Tyr Ile Lys Ser Val Lys Gly Val 
 385                390                395                400
Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                 405                410                415
Glu Gln Ser Gly Met Met Gly Gly Lys Thr Leu Asn Thr Phe Tyr Thr 
             420                425                430
Gln Leu Val Leu Met Pro Gln Val Leu His Tyr Ala Gln Tyr Val Leu 
         435                440                445
Leu Gly Leu Gly Gly Leu Leu Leu Leu Val Pro Ile Ile Tyr Gln Leu 
     450                455                460
Arg Ser Gln Glu Lys Cys Phe Leu Phe Trp Ser Gly Ser Lys Lys Gly 
 465                470                475                480
Ser Gln Asp Lys Glu Ala Met Gln Ala Tyr Ser Glu Ser Leu Met Ser 
                 485                490                495
Pro Ala Ala Lys Gly Thr Val Leu Gln Glu Ala Lys Leu Ter 
             500                505                510



<210> 2300
<211> 2566
<212> DNA
<213> Homo sapiens
<308> Z22555
<400> 2300

cgtcgccgt  cccgtctcc  gccaggcgc  gagccctgc  agccgcggg  gggccccag  60
cgcgcagac  tgggctgct  cgccaaagc  cgctgggct  ccggggcgc  gggcgtcgc  120
gggctactg  gcgctgtgc  gggcgctgt  atgatcgtg  tggtgccgt  gctcatcaa  180
cagcaggtc  ttaagaacg  gcgcatcga  cccagtagc  tgtccttca  catgtggaa  240
gagatccct  tccccttct  tctctccgt  tacttcttt  acgtcatga  ccccagcga  300
atcctgaag  gcgagaagc  gcaggtgcg  gagcgcggg  cctacgtgt  cagggagtc  360
aggcacaaa  gcaacatca  cttcaacaa  aacgacacc  tgtccttcc  cgagtaccg  420
accttccag  tccagccct  caagtccca  ggctcggag  gcgactaca  cgtcatgcc  480
aacatcctg  tcttgggtg  ggcggtgat  atggagaat  agcccatga  cctgaagct  540
atcatgacc  tggcattca  caccctcgg  gaacgtgcc  tcatgaacc  cactgtggg  600
gagatcatg  ggggctaca  ggaccccct  gtgaatctc  tcaacaagt  ctttccagg  660
atgttcccc  tcaaggaca  gttcggatt  tttgctgag  tcaacaact  cgactctgg  720
ctcttcacg  tgttcacgg  ggtccagaa  atcagcagg  tccacctcg  ggacaagtg  780
aacgggctg  gcaaggttg  cttctggca  tccgatcag  gcaacatga  caatggaac  840
tctgggcaa  tgtggccgc  cttcatgac  cctgagtcc  cgctggagt  ctacagccc  900
gaggcctgc  gatccatga  gctaatgta  aaggagtca  gggtgtttg  aggcatccc  960
acctatcgc  tcgtggctc  caaaaccct  tttgccaac  ggtccatct  cccacccaa  1020
gaaggcttc  gcccgtgcc  ggagtctgg  attcagaac  tcagcacct  caggttcag  1080
gcccccttg  ttctctccc  tcctcactt  ctcaacgcc  acccggttc  ggcagaagc  1140
gtgactggc  tgcacccta  ccaggaggc  cactccttg  tcctggaca  ccacccggt  1200
acgggaatc  ccatgaact  ctctgtgaa  ctgcagctg  gcctctaca  gaaatctgt  1260
gcaggcatt  gacaaactg  gaagattga  cctgtggtc  tgccgctgc  ctggtttgc  1320
gagagcggg  ccatggagg  ggagactct  cacacattc  acactcagc  ggtgttgat  1380
cccaaggtg  tgcactatg  ccagtacgt  ctcctggcg  tgggctgcg  cctgctgct  1440
gtccctgtc  tctgccaaa  ccggagcca  gagaaatgc  atttatttt  gagtagtag  1500
aaaaagggc  caaaggata  ggaggccat  caggcctat  ctgaatccc  gatgacatc  1560
gctcccaag  gctctgtgc  gcaggaagc  aaactgtag  gtcctgagg  caccgtgag  1620
cagccaggc  tggccgctg  gcctgaccg  ccccccagc  cctacaccc  gcttctccc  1680
gactctccc  gcagacagc  ccccagccc  acagcctga  cctcccagc  gccatgtgc  1740
tgttgcaca  ctgcacaca  gccctggca  acatacaca  atgcgtgca  gcttgtgca  1800
acactcagg  atggagctg  tgctgaagg  acttgtagg  agaggctcg  caacaagca  1860
tgttctgga  ccttctctc  acgtggccc  caggctgac  acaggggct  tgggtcctg  1920
gtccccttc  tcgggtgag  ctggcctgt  ccgttcagc  gttgggcca  gcttcctcc  1980
ctccaaggt  aaacactgc  gtcccggtg  ggtggctcc  catgcagga  gggccaggc  2040
gggagtgcc  ccttcctgt  ccaaattca  tggggactc  gtgcccagg  cctggcacg  2100
gctttggcc  tggtctacc  gccaggcca  gcaaagcgc  tttacacag  cctcggaaa  2160
caatggagt  agcacaaga  gccctgtgc  gctgcccga  ggtctccgc  caccccggc  2220
ggactttga  ccccccgaa  tcttcacag  cactgcatc  ggttgtctg  cgccctttt  2280
ctccagcct  aactgacat  atcctatgg  ctgagccgg  cactctctg  ccgaagtgg  2340
gcaggctgt  cccccgagc  gcccccacc  cctcacagg  tccctcaga  tataggtgc  2400
caggctgag  tgaagaggc  tgggggccc  gccttccgg  cgctcctgg  ccctggggc  2460
aacctgtga  ccttttcta  tggaataga  atgagtttt  tcatctttg  aaaataatt  2520
actcttgaa  taataaacg  ttaaaaaaa  ggaaaaaaa  aaaaaa  2566



<210> 2301
<211> 510
<212> PRT
<213> Homo sapiens
<308> Z22555
<400> 2301

Met Gly Cys Ser Ala Lys Ala Arg Trp Ala Ala Gly Ala Leu Gly Val 
  1               5                  10                  15
Ala Gly Leu Leu Cys Ala Val Leu Gly Ala Val Met Ile Val Met Val 
             20                  25                  30
Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
         35                  40                  45
Ser Ser Leu Ser Phe Asn Met Trp Lys Glu Ile Pro Ile Pro Phe Tyr 
     50                  55                  60
Leu Ser Val Tyr Phe Phe Asp Val Met Asn Pro Ser Glu Ile Leu Lys 
 65                  70                  75                  80
Gly Glu Lys Pro Gln Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                 85                  90                  95
Ser Arg His Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp Thr Val Ser 
             100                105                110
Phe Leu Glu Tyr Arg Thr Phe Gln Phe Gln Pro Ser Lys Ser His Gly 
         115                120                125
Ser Glu Ser Asp Tyr Ile Val Met Pro Asn Ile Leu Val Leu Gly Ala 
     130                135                140
Ala Val Met Met Glu Asn Lys Pro Met Thr Leu Lys Leu Ile Met Thr 
 145                150                155                160
Leu Ala Phe Thr Thr Leu Gly Glu Arg Ala Phe Met Asn Arg Thr Val 
                 165                170                175
Gly Glu Ile Met Trp Gly Tyr Lys Asp Pro Leu Val Asn Leu Ile Asn 
             180                185                190
Lys Tyr Phe Pro Gly Met Phe Pro Phe Lys Asp Lys Phe Gly Leu Phe 
         195                200                205
Ala Glu Leu Asn Asn Ser Asp Ser Gly Leu Phe Thr Val Phe Thr Gly 
     210                215                220
Val Gln Asn Ile Ser Arg Ile His Leu Val Asp Lys Trp Asn Gly Leu 
 225                230                235                240
Ser Lys Val Asp Phe Trp His Ser Asp Gln Cys Asn Met Ile Asn Gly 
                 245                250                255
Thr Ser Gly Gln Met Trp Pro Pro Phe Met Thr Pro Glu Ser Ser Leu 
             260                265                270
Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Met Tyr Lys 
         275                280                285
Glu Ser Gly Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Val Ala Pro 
     290                295                300
Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn Glu Gly Phe 
 305                310                315                320
Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                 325                330                335
Ser Ala Pro Leu Phe Leu Ser His Pro His Phe Leu Asn Ala Asp Pro 
             340                345                350
Val Leu Ala Glu Ala Val Thr Gly Leu His Pro Asn Gln Glu Ala His 
         355                360                365
Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
     370                375                380
Ser Val Lys Leu Gln Leu Ser Leu Tyr Met Lys Ser Val Ala Gly Ile 
 385                390                395                400
Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                 405                410                415
Ala Glu Ser Gly Ala Met Glu Gly Glu Thr Leu His Thr Phe Tyr Thr 
             420                425                430
Gln Leu Val Leu Met Pro Lys Val Met His Tyr Ala Gln Tyr Val Leu 
         435                440                445
Leu Ala Leu Gly Cys Val Leu Leu Leu Val Pro Val Ile Cys Gln Ile 
     450                455                460
Arg Ser Gln Glu Lys Cys Tyr Leu Phe Trp Ser Ser Ser Lys Lys Gly 
 465                470                475                480
Ser Lys Asp Lys Glu Ala Ile Gln Ala Tyr Ser Glu Ser Leu Met Thr 
                 485                490                495
Ser Ala Pro Lys Gly Ser Val Leu Gln Glu Ala Lys Leu Ter 
             500                505                510



<210> 2302
<211> 1911
<212> DNA
<213> Rattus norvegicus
<308> D89730
<400> 2302

gatgttgca  acagttttc  taactatgc  gactctggc  ctggtcaag  cacaggtca  60
ggaggaaac  attacatac  cgcaatgca  cgatggata  gaatgggac  ctgtaagac  120
gcagtgcaa  gatattgat  agtgtgaca  tgtaccaga  gcttgcaaa  gtggaatga  180
atgtgtcaa  cactatgga  gatacctct  ccttcctaa  acagcccaa  ttattgtca  240
taacgaaca  cctcagcaa  aaacaccag  tgccgaagc  tcgtcgggt  ctgccactg  300
gaccatagc  gccaggagc  tggctacca  tggtgtgat  cctgggggt  gcttcatag  360
cagtgctac  gcagttgct  gtcctgaag  tcagacagg  cgaaataac  tcgtcattc  420
gaggaaccc  gctgaccct  agcgcatcc  ttccaaccc  tcccaccgg  tccagtgtg  480
agcaggcta  gaacagagt  agcataatg  gtgccaaga  attgatgag  gcacctcag  540
gacccacaa  tgtagattg  accaagtgt  catcaattt  cgtggttcc  tcacatgcc  600
ctgtcttcc  gggtatcag  agcgaggcg  acagtgtgt  gatatagat  agtgctcag  660
gcccccata  tgccaccaa  gatgtgtga  caccccggg  tccttttac  gtcagtgca  720
tcccgggtt  cagctggca  caaacaact  cacttgtgt  gatataaat  aatgtgatg  780
cagcaacca  tgcgctcag  aatgctaca  cattcttgg  tcattcatc  gtcagtgca  840
ccaaggata  gaactgagc  gtgacagac  caactgtga  gacatcgat  aatgcagaa  900
ctcaagcta  ctgtgccag  atcaatgtg  caatgaacc  gggaagttc  catgtatgt  960
tcctcaggg  taccaagtg  tgcgaagca  aacctgtca  gatataaat  aatgtgaga  1020
caccaatga  tgccgagaa  atgaaatgt  ctggaatta  catggtggc  tccgctgtt  1080
cccacaaaa  ccatgtcaa  atccctatg  tctaacgtc  gaaaaccga  gcgtttgcc  1140
ggtctcaaa  accatgtgc  gagacgtgc  ccagtctat  gtctacaaa  acatgaaca  1200
ccgatctga  aggtccgtg  catcagaca  cttccagat  caggcaaca  cgatttatg  1260
aaacaccat  aatactttt  ggattaaat  tggaaatga  aatggagag  tctacctac  1320
acaaacaag  cctgtgagt  caatgctgg  gcttgtgaa  tcgttaaca  gaccaagag  1380
acacatcgt  ggcctggag  tgctgacag  cagtagtat  gggaccttc  gcacaagct  1440
tgtgttaag  ttgacaata  tagtggggc  gttttcatt  taaactttt  ttcacataa  1500
gcctaccac  ggcatttaa  tcagccaaa  aatatcatt  cattaaagt  tattttatt  1560
atagctcta  ctagtacat  tatattcaa  cagctagac  atggtagga  gtgggcatt  1620
aatccataa  agtcaacat  tatctttat  actgtgtgt  aattagaca  tagtccaac  1680
ttcttcttg  agagagcta  gcatatatt  tctagtgaa  cttggattc  ttcctacaa  1740
aatggggcc  agcaatgat  ctgttctgt  gtgaataga  aaatataca  ctccacaaa  1800
aatctcatg  ggattggcc  tctaaacat  aagagcaag  agggttttt  ttttaactt  1860
tttgtaaga  aatggaaaa  agtcaataa  gatatattt  tttagaaaa  g  1911



<210> 2303
<211> 493
<212> PRT
<213> Rattus norvegicus
<308> O35568
<400> 2303

Met Leu Gln Thr Val Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
  1               5                  10                  15
Ser Gln Val Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
             20                  25                  30
Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
         35                  40                  45
Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
     50                  55                  60
Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
 65                  70                  75                  80
Asn Glu Gln Pro Gln Gln Glu Thr Pro Ala Ala Glu Ala Ser Ser Gly 
                 85                  90                  95
Ala Ala Thr Gly Thr Ile Ala Ala Arg Ser Met Ala Thr Ser Gly Val 
             100                105                110
Ile Pro Gly Gly Gly Phe Ile Ala Ser Ala Thr Ala Val Ala Gly Pro 
         115                120                125
Glu Val Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
     130                135                140
Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
 145                150                155                160
Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                 165                170                175
Cys Thr Ser Gly Thr His Asn Cys Arg Leu Asp Gln Val Cys Ile Asn 
             180                185                190
Leu Arg Gly Ser Phe Thr Cys His Cys Leu Pro Gly Tyr Gln Lys Arg 
         195                200                205
Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Ser Val Pro Pro Tyr Cys 
     210                215                220
His Gln Gly Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Asn 
 225                230                235                240
Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                 245                250                255
Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
             260                265                270
Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
         275                280                285
Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
     290                295                300
Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
 305                310                315                320
Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                 325                330                335
Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
             340                345                350
Tyr His Gly Gly Phe Arg Cys Tyr Pro Gln Asn Pro Cys Gln Asp Pro 
         355                360                365
Tyr Val Leu Thr Ser Glu Asn Arg Cys Val Cys Pro Val Ser Asn Thr 
     370                375                380
Met Cys Arg Asp Val Pro Gln Ser Ile Val Tyr Lys Tyr Met Asn Ile 
 385                390                395                400
Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                 405                410                415
Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
             420                425                430
Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
         435                440                445
Leu Val Leu Val Lys Ser Leu Thr Gly Pro Arg Glu His Ile Val Gly 
     450                455                460
Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
 465                470                475                480
Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                 485                490



<210> 2304
<211> 2742
<212> DNA
<213> Homo sapiens
<308> NM_004105
<400> 2304

ctagtattc  actagaact  gaagattgc  ctccgagtt  tttttttgt  attttgtta  60
aaaataaaa  gcttgagca  caattcata  tactgtcac  ggtattttt  ctgtgctgt  120
caaggtaac  ctgctagct  agattcaca  tgttgaaag  ccttttcct  actatgctg  180
ctctggcgc  ggtcaagtc  caggacacc  aagaaacca  cacgtacac  caatgcact  240
acggatatg  gtgggatcc  gtgagacag  aatgcaaag  tattgatga  tgtgacatt  300
tcccagacg  ttgtaaagg  ggaatgaag  gtgtcaacc  ctatggagg  tacctctgc  360
ttccgaaaa  agcccagat  attgtcaat  atgaacagc  tcagcagga  acacaacca  420
cagaaggaa  ctcaggggc  accaccggg  ttgtagctg  cagcagcat  gcaaccagt  480
gagtgttgc  cgggggtgg  tttgtggcc  gtgctgctg  agtcgcagg  cctgaaatg  540
agactggcc  aaataactt  gtcatccgg  ggaacccag  tgaccctca  cgcattccc  600
ccaaccctt  ccaccgtat  cagtgtgca  caggctacg  gcaaagtga  cacaacgtg  660
gccaagaca  agacgagtg  actgcaggg  cgcacaact  tagagcaga  caagtgtgc  720
tcaatttac  gggatcctt  gcatgtcag  gccctcctg  atatcagaa  cgaggggag  780
agtgcgtag  catagatga  tgtaccatc  ctccatatt  ccaccaaag  tgcgtgaat  840
caccaggct  attttattg  cagtgcagt  ctgggtttc  attggcagc  aacaactat  900
cctgcgtag  tataaatga  tgtgatgcc  gcaatcaat  tgctcagca  tgctacaac  960
ttcttggtt  attcatctg  cagtgcaat  aaggatatg  gctaagcag  gacaggctc  1020
actgtgaag  cattgatga  tgcagaacc  caagctacc  gtgtcaata  caatgtgtc  1080
atgaacctg  gaaattctc  tgtatgtgc  cccagggat  ccaagtggt  agaagtaga  1140
catgtcaag  tataaatga  tgtgagacc  caaatgaat  ccgggagga  gaaatgtgt  1200
ggaattatc  tggcggctt  cgttgttat  cacgaaatc  ttgtcaaga  ccctacatt  1260
taacaccag  gaaccgatg  gtttgccca  tctcaaatg  catgtgccg  gaactgccc  1320
agtcaatag  ctacaaata  atgagcatc  gatctgata  gtctgtgcc  tcagacatc  1380
tccagatac  ggccacaac  atttatgcc  acaccatca  tacttttcg  attaaatct  1440
gaaatgaaa  tggagagtt  tacctacga  aaacaagtc  tgtaagtgc  atgcttgtg  1500
tcgtgaagt  attatcagg  ccaagagaa  atatcgtgg  cctggagat  ctgacagtc  1560
gcagtatag  gaccttccg  acaagctct  tgttaagat  gacaataat  gtggggcca  1620
tttcatttt  gtcttttct  agagtcaac  acaggcatt  aagtcagcc  aagaatatt  1680
ttaccttaa  gcactattt  atttataga  atatctagt  catctacat  tctatactg  1740
acactcacc  ataacaaac  attacacca  ggtataaag  gggcattta  tatgtaaag  1800
ttcaaagtt  gtctttatt  ctatatgta  attagacat  aatccacta  actggtctt  1860
ttcaagaga  ctaagtata  actatctgg  gaaacttgg  ttctttcct  taaaagtgg  1920
accaagcaa  gatgatctt  tgtggtgct  aaggaaact  actagagct  cactaacag  1980
ctcataagg  ggcagccat  ataaccatt  aatagcatg  aagggtaag  atgagtttt  2040
aactgcttt  taagaaaat  gaaaaggtc  ataaagata  atttcttta  aaaatgggg  2100
tctgccata  ttgtgttgg  ttttatttt  atatccagc  taaaggtgg  tgtttatta  2160
atagtaata  atcattgct  tacaacatg  tggtttctg  agggtattt  taattttgt  2220
agaaatttt  gattgtgaa  attttgtaa  aaacagtaa  caaaatttt  cagaattcc  2280
aaaatgaac  agatacccc  tagaaaatt  tactattga  aaatctatg  ggaggatat  2340
agaaaataa  ttccttcta  accacattg  aactgacct  aagaagcaa  ctcggaaaa  2400
ataataaca  ccctgaatt  aggcattca  aagatgcag  acaaaatgg  taaaaggta  2460
ttcactgga  aagttttaa  ttctaagta  aatttaaat  ctaacactt  actaattta  2520
aactaaaat  tctcatctt  gtacttgat  ctcacagag  aagaaaatg  tgatggttt  2580
tattcctgg  atccagagt  acagtgaac  taagcaaat  accctccta  ccaattcta  2640
ggaatattt  atacgtctc  ttgtttaaa  tctgactgc  ttactttga  gtatcatat  2700
tttaaataa  aataaatat  cctttagaa  atcactcta  aa  2742



<210> 2305
<211> 493
<212> PRT
<213> Homo sapiens
<308> Q12805
<400> 2305

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
  1               5                  10                  15
Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
             20                  25                  30
Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
         35                  40                  45
Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
     50                  55                  60
Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
 65                  70                  75                  80
Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                 85                  90                  95
Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val 
             100                105                110
Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro 
         115                120                125
Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
     130                135                140
Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
 145                150                155                160
Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                 165                170                175
Cys Thr Ala Gly Thr His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn 
             180                185                190
Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg 
         195                200                205
Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Thr Ile Pro Pro Tyr Cys 
     210                215                220
His Gln Arg Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Ser 
 225                230                235                240
Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                 245                250                255
Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
             260                265                270
Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
         275                280                285
Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
     290                295                300
Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
 305                310                315                320
Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                 325                330                335
Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
             340                345                350
Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro 
         355                360                365
Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala 
     370                375                380
Met Cys Arg Glu Leu Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile 
 385                390                395                400
Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                 405                410                415
Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
             420                425                430
Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
         435                440                445
Leu Val Leu Val Lys Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp 
     450                455                460
Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
 465                470                475                480
Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                 485                490



<210> 2306
<211> 1911
<212> DNA
<213> Rattus norvegicus
<308> D89730
<400> 2306

gatgttgca  acagttttc  taactatgc  gactctggc  ctggtcaag  cacaggtca  60
ggaggaaac  attacatac  cgcaatgca  cgatggata  gaatgggac  ctgtaagac  120
gcagtgcaa  gatattgat  agtgtgaca  tgtaccaga  gcttgcaaa  gtggaatga  180
atgtgtcaa  cactatgga  gatacctct  ccttcctaa  acagcccaa  ttattgtca  240
taacgaaca  cctcagcaa  aaacaccag  tgccgaagc  tcgtcgggt  ctgccactg  300
gaccatagc  gccaggagc  tggctacca  tggtgtgat  cctgggggt  gcttcatag  360
cagtgctac  gcagttgct  gtcctgaag  tcagacagg  cgaaataac  tcgtcattc  420
gaggaaccc  gctgaccct  agcgcatcc  ttccaaccc  tcccaccgg  tccagtgtg  480
agcaggcta  gaacagagt  agcataatg  gtgccaaga  attgatgag  gcacctcag  540
gacccacaa  tgtagattg  accaagtgt  catcaattt  cgtggttcc  tcacatgcc  600
ctgtcttcc  gggtatcag  agcgaggcg  acagtgtgt  gatatagat  agtgctcag  660
gcccccata  tgccaccaa  gatgtgtga  caccccggg  tccttttac  gtcagtgca  720
tcccgggtt  cagctggca  caaacaact  cacttgtgt  gatataaat  aatgtgatg  780
cagcaacca  tgcgctcag  aatgctaca  cattcttgg  tcattcatc  gtcagtgca  840
ccaaggata  gaactgagc  gtgacagac  caactgtga  gacatcgat  aatgcagaa  900
ctcaagcta  ctgtgccag  atcaatgtg  caatgaacc  gggaagttc  catgtatgt  960
tcctcaggg  taccaagtg  tgcgaagca  aacctgtca  gatataaat  aatgtgaga  1020
caccaatga  tgccgagaa  atgaaatgt  ctggaatta  catggtggc  tccgctgtt  1080
cccacaaaa  ccatgtcaa  atccctatg  tctaacgtc  gaaaaccga  gcgtttgcc  1140
ggtctcaaa  accatgtgc  gagacgtgc  ccagtctat  gtctacaaa  acatgaaca  1200
ccgatctga  aggtccgtg  catcagaca  cttccagat  caggcaaca  cgatttatg  1260
aaacaccat  aatactttt  ggattaaat  tggaaatga  aatggagag  tctacctac  1320
acaaacaag  cctgtgagt  caatgctgg  gcttgtgaa  tcgttaaca  gaccaagag  1380
acacatcgt  ggcctggag  tgctgacag  cagtagtat  gggaccttc  gcacaagct  1440
tgtgttaag  ttgacaata  tagtggggc  gttttcatt  taaactttt  ttcacataa  1500
gcctaccac  ggcatttaa  tcagccaaa  aatatcatt  cattaaagt  tattttatt  1560
atagctcta  ctagtacat  tatattcaa  cagctagac  atggtagga  gtgggcatt  1620
aatccataa  agtcaacat  tatctttat  actgtgtgt  aattagaca  tagtccaac  1680
ttcttcttg  agagagcta  gcatatatt  tctagtgaa  cttggattc  ttcctacaa  1740
aatggggcc  agcaatgat  ctgttctgt  gtgaataga  aaatataca  ctccacaaa  1800
aatctcatg  ggattggcc  tctaaacat  aagagcaag  agggttttt  ttttaactt  1860
tttgtaaga  aatggaaaa  agtcaataa  gatatattt  tttagaaaa  g  1911



<210> 2307
<211> 493
<212> PRT
<213> Rattus norvegicus
<308> O35568
<400> 2307

Met Leu Gln Thr Val Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
  1               5                  10                  15
Ser Gln Val Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
             20                  25                  30
Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
         35                  40                  45
Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
     50                  55                  60
Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
 65                  70                  75                  80
Asn Glu Gln Pro Gln Gln Glu Thr Pro Ala Ala Glu Ala Ser Ser Gly 
                 85                  90                  95
Ala Ala Thr Gly Thr Ile Ala Ala Arg Ser Met Ala Thr Ser Gly Val 
             100                105                110
Ile Pro Gly Gly Gly Phe Ile Ala Ser Ala Thr Ala Val Ala Gly Pro 
         115                120                125
Glu Val Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
     130                135                140
Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
 145                150                155                160
Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                 165                170                175
Cys Thr Ser Gly Thr His Asn Cys Arg Leu Asp Gln Val Cys Ile Asn 
             180                185                190
Leu Arg Gly Ser Phe Thr Cys His Cys Leu Pro Gly Tyr Gln Lys Arg 
         195                200                205
Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Ser Val Pro Pro Tyr Cys 
     210                215                220
His Gln Gly Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Asn 
 225                230                235                240
Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                 245                250                255
Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
             260                265                270
Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
         275                280                285
Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
     290                295                300
Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
 305                310                315                320
Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                 325                330                335
Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
             340                345                350
Tyr His Gly Gly Phe Arg Cys Tyr Pro Gln Asn Pro Cys Gln Asp Pro 
         355                360                365
Tyr Val Leu Thr Ser Glu Asn Arg Cys Val Cys Pro Val Ser Asn Thr 
     370                375                380
Met Cys Arg Asp Val Pro Gln Ser Ile Val Tyr Lys Tyr Met Asn Ile 
 385                390                395                400
Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                 405                410                415
Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
             420                425                430
Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
         435                440                445
Leu Val Leu Val Lys Ser Leu Thr Gly Pro Arg Glu His Ile Val Gly 
     450                455                460
Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
 465                470                475                480
Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                 485                490



<210> 2308
<211> 2742
<212> DNA
<213> Homo sapiens
<308> NM_004105
<400> 2308

ctagtattc  actagaact  gaagattgc  ctccgagtt  tttttttgt  attttgtta  60
aaaataaaa  gcttgagca  caattcata  tactgtcac  ggtattttt  ctgtgctgt  120
caaggtaac  ctgctagct  agattcaca  tgttgaaag  ccttttcct  actatgctg  180
ctctggcgc  ggtcaagtc  caggacacc  aagaaacca  cacgtacac  caatgcact  240
acggatatg  gtgggatcc  gtgagacag  aatgcaaag  tattgatga  tgtgacatt  300
tcccagacg  ttgtaaagg  ggaatgaag  gtgtcaacc  ctatggagg  tacctctgc  360
ttccgaaaa  agcccagat  attgtcaat  atgaacagc  tcagcagga  acacaacca  420
cagaaggaa  ctcaggggc  accaccggg  ttgtagctg  cagcagcat  gcaaccagt  480
gagtgttgc  cgggggtgg  tttgtggcc  gtgctgctg  agtcgcagg  cctgaaatg  540
agactggcc  aaataactt  gtcatccgg  ggaacccag  tgaccctca  cgcattccc  600
ccaaccctt  ccaccgtat  cagtgtgca  caggctacg  gcaaagtga  cacaacgtg  660
gccaagaca  agacgagtg  actgcaggg  cgcacaact  tagagcaga  caagtgtgc  720
tcaatttac  gggatcctt  gcatgtcag  gccctcctg  atatcagaa  cgaggggag  780
agtgcgtag  catagatga  tgtaccatc  ctccatatt  ccaccaaag  tgcgtgaat  840
caccaggct  attttattg  cagtgcagt  ctgggtttc  attggcagc  aacaactat  900
cctgcgtag  tataaatga  tgtgatgcc  gcaatcaat  tgctcagca  tgctacaac  960
ttcttggtt  attcatctg  cagtgcaat  aaggatatg  gctaagcag  gacaggctc  1020
actgtgaag  cattgatga  tgcagaacc  caagctacc  gtgtcaata  caatgtgtc  1080
atgaacctg  gaaattctc  tgtatgtgc  cccagggat  ccaagtggt  agaagtaga  1140
catgtcaag  tataaatga  tgtgagacc  caaatgaat  ccgggagga  gaaatgtgt  1200
ggaattatc  tggcggctt  cgttgttat  cacgaaatc  ttgtcaaga  ccctacatt  1260
taacaccag  gaaccgatg  gtttgccca  tctcaaatg  catgtgccg  gaactgccc  1320
agtcaatag  ctacaaata  atgagcatc  gatctgata  gtctgtgcc  tcagacatc  1380
tccagatac  ggccacaac  atttatgcc  acaccatca  tacttttcg  attaaatct  1440
gaaatgaaa  tggagagtt  tacctacga  aaacaagtc  tgtaagtgc  atgcttgtg  1500
tcgtgaagt  attatcagg  ccaagagaa  atatcgtgg  cctggagat  ctgacagtc  1560
gcagtatag  gaccttccg  acaagctct  tgttaagat  gacaataat  gtggggcca  1620
tttcatttt  gtcttttct  agagtcaac  acaggcatt  aagtcagcc  aagaatatt  1680
ttaccttaa  gcactattt  atttataga  atatctagt  catctacat  tctatactg  1740
acactcacc  ataacaaac  attacacca  ggtataaag  gggcattta  tatgtaaag  1800
ttcaaagtt  gtctttatt  ctatatgta  attagacat  aatccacta  actggtctt  1860
ttcaagaga  ctaagtata  actatctgg  gaaacttgg  ttctttcct  taaaagtgg  1920
accaagcaa  gatgatctt  tgtggtgct  aaggaaact  actagagct  cactaacag  1980
ctcataagg  ggcagccat  ataaccatt  aatagcatg  aagggtaag  atgagtttt  2040
aactgcttt  taagaaaat  gaaaaggtc  ataaagata  atttcttta  aaaatgggg  2100
tctgccata  ttgtgttgg  ttttatttt  atatccagc  taaaggtgg  tgtttatta  2160
atagtaata  atcattgct  tacaacatg  tggtttctg  agggtattt  taattttgt  2220
agaaatttt  gattgtgaa  attttgtaa  aaacagtaa  caaaatttt  cagaattcc  2280
aaaatgaac  agatacccc  tagaaaatt  tactattga  aaatctatg  ggaggatat  2340
agaaaataa  ttccttcta  accacattg  aactgacct  aagaagcaa  ctcggaaaa  2400
ataataaca  ccctgaatt  aggcattca  aagatgcag  acaaaatgg  taaaaggta  2460
ttcactgga  aagttttaa  ttctaagta  aatttaaat  ctaacactt  actaattta  2520
aactaaaat  tctcatctt  gtacttgat  ctcacagag  aagaaaatg  tgatggttt  2580
tattcctgg  atccagagt  acagtgaac  taagcaaat  accctccta  ccaattcta  2640
ggaatattt  atacgtctc  ttgtttaaa  tctgactgc  ttactttga  gtatcatat  2700
tttaaataa  aataaatat  cctttagaa  atcactcta  aa  2742



<210> 2309
<211> 493
<212> PRT
<213> Homo sapiens
<308> Q12805
<400> 2309

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
  1               5                  10                  15
Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
             20                  25                  30
Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
         35                  40                  45
Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
     50                  55                  60
Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
 65                  70                  75                  80
Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                 85                  90                  95
Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val 
             100                105                110
Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro 
         115                120                125
Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
     130                135                140
Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
 145                150                155                160
Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                 165                170                175
Cys Thr Ala Gly Thr His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn 
             180                185                190
Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg 
         195                200                205
Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Thr Ile Pro Pro Tyr Cys 
     210                215                220
His Gln Arg Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Ser 
 225                230                235                240
Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                 245                250                255
Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
             260                265                270
Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
         275                280                285
Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
     290                295                300
Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
 305                310                315                320
Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                 325                330                335
Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
             340                345                350
Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro 
         355                360                365
Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala 
     370                375                380
Met Cys Arg Glu Leu Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile 
 385                390                395                400
Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                 405                410                415
Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
             420                425                430
Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
         435                440                445
Leu Val Leu Val Lys Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp 
     450                455                460
Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
 465                470                475                480
Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                 485                490



<210> 2310
<211> 1911
<212> DNA
<213> Rattus norvegicus
<308> D89730
<400> 2310

gatgttgca  acagttttc  taactatgc  gactctggc  ctggtcaag  cacaggtca  60
ggaggaaac  attacatac  cgcaatgca  cgatggata  gaatgggac  ctgtaagac  120
gcagtgcaa  gatattgat  agtgtgaca  tgtaccaga  gcttgcaaa  gtggaatga  180
atgtgtcaa  cactatgga  gatacctct  ccttcctaa  acagcccaa  ttattgtca  240
taacgaaca  cctcagcaa  aaacaccag  tgccgaagc  tcgtcgggt  ctgccactg  300
gaccatagc  gccaggagc  tggctacca  tggtgtgat  cctgggggt  gcttcatag  360
cagtgctac  gcagttgct  gtcctgaag  tcagacagg  cgaaataac  tcgtcattc  420
gaggaaccc  gctgaccct  agcgcatcc  ttccaaccc  tcccaccgg  tccagtgtg  480
agcaggcta  gaacagagt  agcataatg  gtgccaaga  attgatgag  gcacctcag  540
gacccacaa  tgtagattg  accaagtgt  catcaattt  cgtggttcc  tcacatgcc  600
ctgtcttcc  gggtatcag  agcgaggcg  acagtgtgt  gatatagat  agtgctcag  660
gcccccata  tgccaccaa  gatgtgtga  caccccggg  tccttttac  gtcagtgca  720
tcccgggtt  cagctggca  caaacaact  cacttgtgt  gatataaat  aatgtgatg  780
cagcaacca  tgcgctcag  aatgctaca  cattcttgg  tcattcatc  gtcagtgca  840
ccaaggata  gaactgagc  gtgacagac  caactgtga  gacatcgat  aatgcagaa  900
ctcaagcta  ctgtgccag  atcaatgtg  caatgaacc  gggaagttc  catgtatgt  960
tcctcaggg  taccaagtg  tgcgaagca  aacctgtca  gatataaat  aatgtgaga  1020
caccaatga  tgccgagaa  atgaaatgt  ctggaatta  catggtggc  tccgctgtt  1080
cccacaaaa  ccatgtcaa  atccctatg  tctaacgtc  gaaaaccga  gcgtttgcc  1140
ggtctcaaa  accatgtgc  gagacgtgc  ccagtctat  gtctacaaa  acatgaaca  1200
ccgatctga  aggtccgtg  catcagaca  cttccagat  caggcaaca  cgatttatg  1260
aaacaccat  aatactttt  ggattaaat  tggaaatga  aatggagag  tctacctac  1320
acaaacaag  cctgtgagt  caatgctgg  gcttgtgaa  tcgttaaca  gaccaagag  1380
acacatcgt  ggcctggag  tgctgacag  cagtagtat  gggaccttc  gcacaagct  1440
tgtgttaag  ttgacaata  tagtggggc  gttttcatt  taaactttt  ttcacataa  1500
gcctaccac  ggcatttaa  tcagccaaa  aatatcatt  cattaaagt  tattttatt  1560
atagctcta  ctagtacat  tatattcaa  cagctagac  atggtagga  gtgggcatt  1620
aatccataa  agtcaacat  tatctttat  actgtgtgt  aattagaca  tagtccaac  1680
ttcttcttg  agagagcta  gcatatatt  tctagtgaa  cttggattc  ttcctacaa  1740
aatggggcc  agcaatgat  ctgttctgt  gtgaataga  aaatataca  ctccacaaa  1800
aatctcatg  ggattggcc  tctaaacat  aagagcaag  agggttttt  ttttaactt  1860
tttgtaaga  aatggaaaa  agtcaataa  gatatattt  tttagaaaa  g  1911



<210> 2311
<211> 493
<212> PRT
<213> Rattus norvegicus
<308> O35568
<400> 2311

Met Leu Gln Thr Val Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
  1               5                  10                  15
Ser Gln Val Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
             20                  25                  30
Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
         35                  40                  45
Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
     50                  55                  60
Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
 65                  70                  75                  80
Asn Glu Gln Pro Gln Gln Glu Thr Pro Ala Ala Glu Ala Ser Ser Gly 
                 85                  90                  95
Ala Ala Thr Gly Thr Ile Ala Ala Arg Ser Met Ala Thr Ser Gly Val 
             100                105                110
Ile Pro Gly Gly Gly Phe Ile Ala Ser Ala Thr Ala Val Ala Gly Pro 
         115                120                125
Glu Val Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
     130                135                140
Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
 145                150                155                160
Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                 165                170                175
Cys Thr Ser Gly Thr His Asn Cys Arg Leu Asp Gln Val Cys Ile Asn 
             180                185                190
Leu Arg Gly Ser Phe Thr Cys His Cys Leu Pro Gly Tyr Gln Lys Arg 
         195                200                205
Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Ser Val Pro Pro Tyr Cys 
     210                215                220
His Gln Gly Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Asn 
 225                230                235                240
Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                 245                250                255
Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
             260                265                270
Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
         275                280                285
Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
     290                295                300
Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
 305                310                315                320
Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                 325                330                335
Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
             340                345                350
Tyr His Gly Gly Phe Arg Cys Tyr Pro Gln Asn Pro Cys Gln Asp Pro 
         355                360                365
Tyr Val Leu Thr Ser Glu Asn Arg Cys Val Cys Pro Val Ser Asn Thr 
     370                375                380
Met Cys Arg Asp Val Pro Gln Ser Ile Val Tyr Lys Tyr Met Asn Ile 
 385                390                395                400
Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                 405                410                415
Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
             420                425                430
Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
         435                440                445
Leu Val Leu Val Lys Ser Leu Thr Gly Pro Arg Glu His Ile Val Gly 
     450                455                460
Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
 465                470                475                480
Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                 485                490



<210> 2312
<211> 2742
<212> DNA
<213> Homo sapiens
<308> NM_004105
<400> 2312

ctagtattc  actagaact  gaagattgc  ctccgagtt  tttttttgt  attttgtta  60
aaaataaaa  gcttgagca  caattcata  tactgtcac  ggtattttt  ctgtgctgt  120
caaggtaac  ctgctagct  agattcaca  tgttgaaag  ccttttcct  actatgctg  180
ctctggcgc  ggtcaagtc  caggacacc  aagaaacca  cacgtacac  caatgcact  240
acggatatg  gtgggatcc  gtgagacag  aatgcaaag  tattgatga  tgtgacatt  300
tcccagacg  ttgtaaagg  ggaatgaag  gtgtcaacc  ctatggagg  tacctctgc  360
ttccgaaaa  agcccagat  attgtcaat  atgaacagc  tcagcagga  acacaacca  420
cagaaggaa  ctcaggggc  accaccggg  ttgtagctg  cagcagcat  gcaaccagt  480
gagtgttgc  cgggggtgg  tttgtggcc  gtgctgctg  agtcgcagg  cctgaaatg  540
agactggcc  aaataactt  gtcatccgg  ggaacccag  tgaccctca  cgcattccc  600
ccaaccctt  ccaccgtat  cagtgtgca  caggctacg  gcaaagtga  cacaacgtg  660
gccaagaca  agacgagtg  actgcaggg  cgcacaact  tagagcaga  caagtgtgc  720
tcaatttac  gggatcctt  gcatgtcag  gccctcctg  atatcagaa  cgaggggag  780
agtgcgtag  catagatga  tgtaccatc  ctccatatt  ccaccaaag  tgcgtgaat  840
caccaggct  attttattg  cagtgcagt  ctgggtttc  attggcagc  aacaactat  900
cctgcgtag  tataaatga  tgtgatgcc  gcaatcaat  tgctcagca  tgctacaac  960
ttcttggtt  attcatctg  cagtgcaat  aaggatatg  gctaagcag  gacaggctc  1020
actgtgaag  cattgatga  tgcagaacc  caagctacc  gtgtcaata  caatgtgtc  1080
atgaacctg  gaaattctc  tgtatgtgc  cccagggat  ccaagtggt  agaagtaga  1140
catgtcaag  tataaatga  tgtgagacc  caaatgaat  ccgggagga  gaaatgtgt  1200
ggaattatc  tggcggctt  cgttgttat  cacgaaatc  ttgtcaaga  ccctacatt  1260
taacaccag  gaaccgatg  gtttgccca  tctcaaatg  catgtgccg  gaactgccc  1320
agtcaatag  ctacaaata  atgagcatc  gatctgata  gtctgtgcc  tcagacatc  1380
tccagatac  ggccacaac  atttatgcc  acaccatca  tacttttcg  attaaatct  1440
gaaatgaaa  tggagagtt  tacctacga  aaacaagtc  tgtaagtgc  atgcttgtg  1500
tcgtgaagt  attatcagg  ccaagagaa  atatcgtgg  cctggagat  ctgacagtc  1560
gcagtatag  gaccttccg  acaagctct  tgttaagat  gacaataat  gtggggcca  1620
tttcatttt  gtcttttct  agagtcaac  acaggcatt  aagtcagcc  aagaatatt  1680
ttaccttaa  gcactattt  atttataga  atatctagt  catctacat  tctatactg  1740
acactcacc  ataacaaac  attacacca  ggtataaag  gggcattta  tatgtaaag  1800
ttcaaagtt  gtctttatt  ctatatgta  attagacat  aatccacta  actggtctt  1860
ttcaagaga  ctaagtata  actatctgg  gaaacttgg  ttctttcct  taaaagtgg  1920
accaagcaa  gatgatctt  tgtggtgct  aaggaaact  actagagct  cactaacag  1980
ctcataagg  ggcagccat  ataaccatt  aatagcatg  aagggtaag  atgagtttt  2040
aactgcttt  taagaaaat  gaaaaggtc  ataaagata  atttcttta  aaaatgggg  2100
tctgccata  ttgtgttgg  ttttatttt  atatccagc  taaaggtgg  tgtttatta  2160
atagtaata  atcattgct  tacaacatg  tggtttctg  agggtattt  taattttgt  2220
agaaatttt  gattgtgaa  attttgtaa  aaacagtaa  caaaatttt  cagaattcc  2280
aaaatgaac  agatacccc  tagaaaatt  tactattga  aaatctatg  ggaggatat  2340
agaaaataa  ttccttcta  accacattg  aactgacct  aagaagcaa  ctcggaaaa  2400
ataataaca  ccctgaatt  aggcattca  aagatgcag  acaaaatgg  taaaaggta  2460
ttcactgga  aagttttaa  ttctaagta  aatttaaat  ctaacactt  actaattta  2520
aactaaaat  tctcatctt  gtacttgat  ctcacagag  aagaaaatg  tgatggttt  2580
tattcctgg  atccagagt  acagtgaac  taagcaaat  accctccta  ccaattcta  2640
ggaatattt  atacgtctc  ttgtttaaa  tctgactgc  ttactttga  gtatcatat  2700
tttaaataa  aataaatat  cctttagaa  atcactcta  aa  2742



<210> 2313
<211> 493
<212> PRT
<213> Homo sapiens
<308> Q12805
<400> 2313

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
  1               5                  10                  15
Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
             20                  25                  30
Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
         35                  40                  45
Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
     50                  55                  60
Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
 65                  70                  75                  80
Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                 85                  90                  95
Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val 
             100                105                110
Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro 
         115                120                125
Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
     130                135                140
Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
 145                150                155                160
Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                 165                170                175
Cys Thr Ala Gly Thr His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn 
             180                185                190
Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg 
         195                200                205
Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Thr Ile Pro Pro Tyr Cys 
     210                215                220
His Gln Arg Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Ser 
 225                230                235                240
Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                 245                250                255
Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
             260                265                270
Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
         275                280                285
Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
     290                295                300
Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
 305                310                315                320
Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                 325                330                335
Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
             340                345                350
Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro 
         355                360                365
Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala 
     370                375                380
Met Cys Arg Glu Leu Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile 
 385                390                395                400
Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                 405                410                415
Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
             420                425                430
Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
         435                440                445
Leu Val Leu Val Lys Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp 
     450                455                460
Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
 465                470                475                480
Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                 485                490



<210> 2314
<211> 1911
<212> DNA
<213> Rattus norvegicus
<308> D89730
<400> 2314

gatgttgca  acagttttc  taactatgc  gactctggc  ctggtcaag  cacaggtca  60
ggaggaaac  attacatac  cgcaatgca  cgatggata  gaatgggac  ctgtaagac  120
gcagtgcaa  gatattgat  agtgtgaca  tgtaccaga  gcttgcaaa  gtggaatga  180
atgtgtcaa  cactatgga  gatacctct  ccttcctaa  acagcccaa  ttattgtca  240
taacgaaca  cctcagcaa  aaacaccag  tgccgaagc  tcgtcgggt  ctgccactg  300
gaccatagc  gccaggagc  tggctacca  tggtgtgat  cctgggggt  gcttcatag  360
cagtgctac  gcagttgct  gtcctgaag  tcagacagg  cgaaataac  tcgtcattc  420
gaggaaccc  gctgaccct  agcgcatcc  ttccaaccc  tcccaccgg  tccagtgtg  480
agcaggcta  gaacagagt  agcataatg  gtgccaaga  attgatgag  gcacctcag  540
gacccacaa  tgtagattg  accaagtgt  catcaattt  cgtggttcc  tcacatgcc  600
ctgtcttcc  gggtatcag  agcgaggcg  acagtgtgt  gatatagat  agtgctcag  660
gcccccata  tgccaccaa  gatgtgtga  caccccggg  tccttttac  gtcagtgca  720
tcccgggtt  cagctggca  caaacaact  cacttgtgt  gatataaat  aatgtgatg  780
cagcaacca  tgcgctcag  aatgctaca  cattcttgg  tcattcatc  gtcagtgca  840
ccaaggata  gaactgagc  gtgacagac  caactgtga  gacatcgat  aatgcagaa  900
ctcaagcta  ctgtgccag  atcaatgtg  caatgaacc  gggaagttc  catgtatgt  960
tcctcaggg  taccaagtg  tgcgaagca  aacctgtca  gatataaat  aatgtgaga  1020
caccaatga  tgccgagaa  atgaaatgt  ctggaatta  catggtggc  tccgctgtt  1080
cccacaaaa  ccatgtcaa  atccctatg  tctaacgtc  gaaaaccga  gcgtttgcc  1140
ggtctcaaa  accatgtgc  gagacgtgc  ccagtctat  gtctacaaa  acatgaaca  1200
ccgatctga  aggtccgtg  catcagaca  cttccagat  caggcaaca  cgatttatg  1260
aaacaccat  aatactttt  ggattaaat  tggaaatga  aatggagag  tctacctac  1320
acaaacaag  cctgtgagt  caatgctgg  gcttgtgaa  tcgttaaca  gaccaagag  1380
acacatcgt  ggcctggag  tgctgacag  cagtagtat  gggaccttc  gcacaagct  1440
tgtgttaag  ttgacaata  tagtggggc  gttttcatt  taaactttt  ttcacataa  1500
gcctaccac  ggcatttaa  tcagccaaa  aatatcatt  cattaaagt  tattttatt  1560
atagctcta  ctagtacat  tatattcaa  cagctagac  atggtagga  gtgggcatt  1620
aatccataa  agtcaacat  tatctttat  actgtgtgt  aattagaca  tagtccaac  1680
ttcttcttg  agagagcta  gcatatatt  tctagtgaa  cttggattc  ttcctacaa  1740
aatggggcc  agcaatgat  ctgttctgt  gtgaataga  aaatataca  ctccacaaa  1800
aatctcatg  ggattggcc  tctaaacat  aagagcaag  agggttttt  ttttaactt  1860
tttgtaaga  aatggaaaa  agtcaataa  gatatattt  tttagaaaa  g  1911



<210> 2315
<211> 493
<212> PRT
<213> Rattus norvegicus
<308> O35568
<400> 2315

Met Leu Gln Thr Val Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
  1               5                  10                  15
Ser Gln Val Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
             20                  25                  30
Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
         35                  40                  45
Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
     50                  55                  60
Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
 65                  70                  75                  80
Asn Glu Gln Pro Gln Gln Glu Thr Pro Ala Ala Glu Ala Ser Ser Gly 
                 85                  90                  95
Ala Ala Thr Gly Thr Ile Ala Ala Arg Ser Met Ala Thr Ser Gly Val 
             100                105                110
Ile Pro Gly Gly Gly Phe Ile Ala Ser Ala Thr Ala Val Ala Gly Pro 
         115                120                125
Glu Val Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
     130                135                140
Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
 145                150                155                160
Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                 165                170                175
Cys Thr Ser Gly Thr His Asn Cys Arg Leu Asp Gln Val Cys Ile Asn 
             180                185                190
Leu Arg Gly Ser Phe Thr Cys His Cys Leu Pro Gly Tyr Gln Lys Arg 
         195                200                205
Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Ser Val Pro Pro Tyr Cys 
     210                215                220
His Gln Gly Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Asn 
 225                230                235                240
Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                 245                250                255
Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
             260                265                270
Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
         275                280                285
Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
     290                295                300
Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
 305                310                315                320
Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                 325                330                335
Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
             340                345                350
Tyr His Gly Gly Phe Arg Cys Tyr Pro Gln Asn Pro Cys Gln Asp Pro 
         355                360                365
Tyr Val Leu Thr Ser Glu Asn Arg Cys Val Cys Pro Val Ser Asn Thr 
     370                375                380
Met Cys Arg Asp Val Pro Gln Ser Ile Val Tyr Lys Tyr Met Asn Ile 
 385                390                395                400
Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                 405                410                415
Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
             420                425                430
Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
         435                440                445
Leu Val Leu Val Lys Ser Leu Thr Gly Pro Arg Glu His Ile Val Gly 
     450                455                460
Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
 465                470                475                480
Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                 485                490



<210> 2316
<211> 2742
<212> DNA
<213> Homo sapiens
<308> NM_004105
<400> 2316

ctagtattc  actagaact  gaagattgc  ctccgagtt  tttttttgt  attttgtta  60
aaaataaaa  gcttgagca  caattcata  tactgtcac  ggtattttt  ctgtgctgt  120
caaggtaac  ctgctagct  agattcaca  tgttgaaag  ccttttcct  actatgctg  180
ctctggcgc  ggtcaagtc  caggacacc  aagaaacca  cacgtacac  caatgcact  240
acggatatg  gtgggatcc  gtgagacag  aatgcaaag  tattgatga  tgtgacatt  300
tcccagacg  ttgtaaagg  ggaatgaag  gtgtcaacc  ctatggagg  tacctctgc  360
ttccgaaaa  agcccagat  attgtcaat  atgaacagc  tcagcagga  acacaacca  420
cagaaggaa  ctcaggggc  accaccggg  ttgtagctg  cagcagcat  gcaaccagt  480
gagtgttgc  cgggggtgg  tttgtggcc  gtgctgctg  agtcgcagg  cctgaaatg  540
agactggcc  aaataactt  gtcatccgg  ggaacccag  tgaccctca  cgcattccc  600
ccaaccctt  ccaccgtat  cagtgtgca  caggctacg  gcaaagtga  cacaacgtg  660
gccaagaca  agacgagtg  actgcaggg  cgcacaact  tagagcaga  caagtgtgc  720
tcaatttac  gggatcctt  gcatgtcag  gccctcctg  atatcagaa  cgaggggag  780
agtgcgtag  catagatga  tgtaccatc  ctccatatt  ccaccaaag  tgcgtgaat  840
caccaggct  attttattg  cagtgcagt  ctgggtttc  attggcagc  aacaactat  900
cctgcgtag  tataaatga  tgtgatgcc  gcaatcaat  tgctcagca  tgctacaac  960
ttcttggtt  attcatctg  cagtgcaat  aaggatatg  gctaagcag  gacaggctc  1020
actgtgaag  cattgatga  tgcagaacc  caagctacc  gtgtcaata  caatgtgtc  1080
atgaacctg  gaaattctc  tgtatgtgc  cccagggat  ccaagtggt  agaagtaga  1140
catgtcaag  tataaatga  tgtgagacc  caaatgaat  ccgggagga  gaaatgtgt  1200
ggaattatc  tggcggctt  cgttgttat  cacgaaatc  ttgtcaaga  ccctacatt  1260
taacaccag  gaaccgatg  gtttgccca  tctcaaatg  catgtgccg  gaactgccc  1320
agtcaatag  ctacaaata  atgagcatc  gatctgata  gtctgtgcc  tcagacatc  1380
tccagatac  ggccacaac  atttatgcc  acaccatca  tacttttcg  attaaatct  1440
gaaatgaaa  tggagagtt  tacctacga  aaacaagtc  tgtaagtgc  atgcttgtg  1500
tcgtgaagt  attatcagg  ccaagagaa  atatcgtgg  cctggagat  ctgacagtc  1560
gcagtatag  gaccttccg  acaagctct  tgttaagat  gacaataat  gtggggcca  1620
tttcatttt  gtcttttct  agagtcaac  acaggcatt  aagtcagcc  aagaatatt  1680
ttaccttaa  gcactattt  atttataga  atatctagt  catctacat  tctatactg  1740
acactcacc  ataacaaac  attacacca  ggtataaag  gggcattta  tatgtaaag  1800
ttcaaagtt  gtctttatt  ctatatgta  attagacat  aatccacta  actggtctt  1860
ttcaagaga  ctaagtata  actatctgg  gaaacttgg  ttctttcct  taaaagtgg  1920
accaagcaa  gatgatctt  tgtggtgct  aaggaaact  actagagct  cactaacag  1980
ctcataagg  ggcagccat  ataaccatt  aatagcatg  aagggtaag  atgagtttt  2040
aactgcttt  taagaaaat  gaaaaggtc  ataaagata  atttcttta  aaaatgggg  2100
tctgccata  ttgtgttgg  ttttatttt  atatccagc  taaaggtgg  tgtttatta  2160
atagtaata  atcattgct  tacaacatg  tggtttctg  agggtattt  taattttgt  2220
agaaatttt  gattgtgaa  attttgtaa  aaacagtaa  caaaatttt  cagaattcc  2280
aaaatgaac  agatacccc  tagaaaatt  tactattga  aaatctatg  ggaggatat  2340
agaaaataa  ttccttcta  accacattg  aactgacct  aagaagcaa  ctcggaaaa  2400
ataataaca  ccctgaatt  aggcattca  aagatgcag  acaaaatgg  taaaaggta  2460
ttcactgga  aagttttaa  ttctaagta  aatttaaat  ctaacactt  actaattta  2520
aactaaaat  tctcatctt  gtacttgat  ctcacagag  aagaaaatg  tgatggttt  2580
tattcctgg  atccagagt  acagtgaac  taagcaaat  accctccta  ccaattcta  2640
ggaatattt  atacgtctc  ttgtttaaa  tctgactgc  ttactttga  gtatcatat  2700
tttaaataa  aataaatat  cctttagaa  atcactcta  aa  2742



<210> 2317
<211> 493
<212> PRT
<213> Homo sapiens
<308> Q12805
<400> 2317

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
  1               5                  10                  15
Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
             20                  25                  30
Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
         35                  40                  45
Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
     50                  55                  60
Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
 65                  70                  75                  80
Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                 85                  90                  95
Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val 
             100                105                110
Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro 
         115                120                125
Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
     130                135                140
Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
 145                150                155                160
Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                 165                170                175
Cys Thr Ala Gly Thr His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn 
             180                185                190
Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg 
         195                200                205
Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Thr Ile Pro Pro Tyr Cys 
     210                215                220
His Gln Arg Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Ser 
 225                230                235                240
Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                 245                250                255
Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
             260                265                270
Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
         275                280                285
Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
     290                295                300
Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
 305                310                315                320
Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                 325                330                335
Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
             340                345                350
Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro 
         355                360                365
Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala 
     370                375                380
Met Cys Arg Glu Leu Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile 
 385                390                395                400
Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                 405                410                415
Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
             420                425                430
Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
         435                440                445
Leu Val Leu Val Lys Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp 
     450                455                460
Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
 465                470                475                480
Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                 485                490



<210> 2318
<211> 4269
<212> DNA
<213> Rattus norvegicus
<308> D89983
<400> 2318

tctcggccg  ggtgtttcc  tttctctcc  tggttgtcg  ctgctctgc  cttctcatc  60
ttctcgctc  gctgctctg  ggagtgacg  ggctgaatc  tctccccac  cagttcgcg  120
ttttcttct  tttctcgcg  cgctccatt  ctccagtcc  gctgccgcc  ccactgctg  180
tcagctggt  tcggtgccg  gcgtttccc  cacgtcgtc  ccgcagcct  tggcccagg  240
cgccttggg  atttctgct  aaggtaacc  catccctct  taaaaattc  gccgaaaaa  300
agaagacgc  ttacccgac  ctttgggcc  ttatctcac  gcgaacttt  tgaccgagt  360
tacaactac  cagaaggcc  aggagaagt  ctgtataga  agcagttcg  ttttaacgc  420
gagccacct  gggaaccta  ctgatgata  gggggttcc  tctcctaac  tgtccatgg  480
ggtcttcac  tcagaaacc  aagactcac  ttcatccag  ttggtgtca  gtgggctgt  540
gctgccagg  ttatcttgt  attatatga  agatgtatc  gtttcttct  aagtgcagt  600
aactgtaga  gcctttgta  caggtgtgt  acaagtttg  tgcatattc  aaggaccca  660
acataggct  ggtggcccg  ctcttgttt  tcctggttt  tgactttcg  ctttgtgga  720
tacggctga  atgaaagga  ttattgacg  tgcaaacta  tccgttggc  tgttggatg  780
aggaacaaa  cttggaaat  ttattgata  ctatgttta  gaacatacc  tgacaggaa  840
aaatgcatt  tttgtgggg  atcttggga  gatcgtgaa  aagcacagt  agtggcaga  900
cgtggtggc  cagataaag  cattttaca  ggtgaagtg  aactccact  cagccgtac  960
ggagatctt  gcagctctt  gaactggat  tgcttgttc  accaaaaat  aaatggctt  1020
agtgcaaga  ttaggcgta  ctccagaaa  catcattta  acaagtcct  gtaagcaag  1080
atctcagat  aagtacgca  caaaagttg  agtaaatat  atgacatgt  acaatgaag  1140
tgaattaaa  aaaattgcg  ggaatcacc  aaatgccaa  gtcttacta  atattgcaa  1200
agaagataa  attggaggt  aagatggta  tatgaagtt  ggcactaca  tgaagaact  1260
taggcatct  ttggaatgt  ccaaggaac  tgatgtcca  ataattggg  ttaaatttc  1320
tatttcaag  gcttgcaaa  aatatcaag  ctatgtcca  gccctgtct  atgctcgat  1380
tgtgtttga  atggctggg  agtttggct  tacaatgaa  atgttagac  tcggtggag  1440
cttcacagg  actgaaatt  agttggaag  ggttaatca  gttatcagt  ctctgttgg  1500
tatttactt  cctgaagga  ctggcattc  gatcatttc  gaacctgga  gctactatg  1560
atcttctgc  tttacgctt  cagtcaata  tattgctaa  aaagttgtt  aaaatgata  1620
attatcctc  ggagtagaa  aaaatggga  tgacgagcc  gccttcgtg  actacatga  1680
tgacggtgt  tatggttct  ttgcaagta  gctttctga  gacttaaat  ctgttccag  1740
ggttcacaa  aaatacaag  aagatgagc  tctgtttac  agcagcctt  ggggtccat  1800
ctgtgacga  cttgatcaa  ttgtggaaa  ttgtcttct  cctgagctg  gcgtgggag  1860
ttggcttat  tttgataac  tgggagcag  ttctttgca  ggaccgtct  cttttagtg  1920
cactcagag  ccagctatt  atttcatga  gtcactcag  gattggtat  agatgcaag  1980
tgctggaat  acttcagat  caatgatga  aaacttctt  tttgcaccc  cttgcattc  2040
gctgagcca  gaagacaac  tctccactg  agcttaaac  ggcattaac  cttctttag  2100
tctgaagtc  caggttaag  ttgtctggt  tacattcca  tgtggggaa  aattcaatc  2160
atctttatt  tgttaattt  cttggaaac  aattcatag  aatagctgt  tgggaccag  2220
caaaatcag  tttcatcta  aattcattg  gggtaatag  ggatttatt  agataatgt  2280
tccagattt  aacatacca  tttgaccca  cccttaagc  tttaaaata  aatatgcaa  2340
aaaatggat  acttagtgg  gatggaagc  cattaattg  gttccccat  aaatcgttt  2400
catacaagt  cacagtttt  ataataagg  ttcctgtta  aagtcttgt  aagttgatg  2460
ctttcaccc  gatctatca  atgtgagtg  aagaccagt  tgacttcat  agatacgtt  2520
agtgtattt  gagtgtgta  atttgtgct  tggactgta  tttaataaa  gtaaaattg  2580
atcatagta  ttgttgtat  tgacctaat  taaccttgt  tgattgcaa  aaaactttg  2640
gtagatttt  ccatttttt  aggctaaaa  tttgggaat  gggctagct  gcaaaggta  2700
ttttgaact  gttgtgtgt  tggtctgtt  tgagagttt  ctttatagt  catttgttt  2760
gtttggctc  atatacttt  tagttattt  attagtaat  taagtaaaa  gtgtttggt  2820
atcattgtg  agttcagat  cattatgga  agtcgatgt  cagtaagca  gatgtttaa  2880
aattttaac  ccagaaaat  ttaatcttg  ataaaccaa  tgtaataat  ataggtgtt  2940
ctgtataga  aggatgcat  gagtacctt  gtaaatctt  gaatcacaa  tcttttggc  3000
gatagaaaa  attttatta  acactgaaa  cttggtcgg  gatggggag  gagactgca  3060
aagactgca  aaccctaac  ttaaagaag  gctatgtct  tttccagca  cctgatgcc  3120
cttcgcaca  acatttaaa  cgagagggc  ttggggtgg  gaagcacac  cttcaattt  3180
tcacttgta  tggtatcaa  ttgcaattt  tttgttgtt  ctgatcttg  tttgaacct  3240
gtcccttag  ttcttgtta  ttcccattt  ttcaagctt  gtaattctt  cttccgtac  3300
aaagcttgg  ggggggtgg  gggaggagt  agcttcact  acctgacac  gttgccagg  3360
attttggct  tgttcactg  tagtgtgtt  gtcctaagt  tcagaatca  agaagtaat  3420
agacaactt  caggggtca  ttttcctac  ttactctat  ttcacaagt  gaattcctg  3480
cctccaaga  gaaatgtga  ttcactttg  tgccaatgg  caggaaatt  tacctgtgc  3540
acataggag  agtgtggga  acacttgaa  agctggatt  tacaccttg  tttcaaggt  3600
gaaagaaat  gatcatgaa  ctctaattt  aaatcaaac  agtaggtgc  taatatttt  3660
gatttgaat  ttgcccact  gaatatcat  ggttctatt  attataaga  caactaagg  3720
ccccagtcc  ctgtcatct  gttgccctt  gactttttt  caaggtata  tatggggtt  3780
atgcaaaat  tgaagctac  atatgcatt  ttgtggtcc  ggaatgcca  aacttaaag  3840
gtggtacaa  ctgagtcct  ggcctgact  tacaggcgt  gtctctgtg  catcagttt  3900
gccttctgc  taggagaaa  gttgtatgt  acacagccc  gaattgcta  ctcacatgt  3960
aatgatagg  aaacataag  atgtctgta  tgtttttga  gactgtttg  cataaatct  4020
aagtcaaac  tatgtattt  aatttggta  gcttaagaa  aattaatgt  aaatctttt  4080
atatgatat  gtaatctca  ttcaaattt  attgcaaat  taaaaccca  atgatttct  4140
tatatagta  attgaactg  caaggtaac  tgtgtgtga  tctgaatac  cagatacaa  4200
gtttttatt  ctcatgctt  actttgatg  cttctatca  gaaatagat  tgaaatttt  4260
tgaaaaaaa  4269



<210> 2319
<211> 448
<212> PRT
<213> Rattus norvegicus
<308> Q63764
<400> 2319

Met Lys Gly Phe Ile Asp Asp Ala Asn Tyr Ser Val Gly Leu Leu Asp 
  1               5                  10                  15
Glu Gly Thr Asn Leu Gly Asn Val Ile Asp Asn Tyr Val Tyr Glu His 
             20                  25                  30
Thr Leu Thr Gly Lys Asn Ala Phe Phe Val Gly Asp Leu Gly Lys Ile 
         35                  40                  45
Val Lys Lys His Ser Gln Trp Gln Asn Val Val Ala Gln Ile Lys Pro 
     50                  55                  60
Phe Tyr Met Val Lys Cys Asn Ser Thr Pro Ala Val Leu Glu Ile Leu 
 65                  70                  75                  80
Ala Ala Leu Gly Thr Gly Phe Ala Cys Ser Thr Lys Asn Glu Met Ala 
                 85                  90                  95
Leu Val Gln Glu Leu Gly Val Ser Pro Glu Asn Ile Ile Tyr Thr Ser 
             100                105                110
Pro Cys Lys Gln Ala Ser Gln Ile Lys Tyr Ala Ala Lys Val Gly Val 
         115                120                125
Asn Ile Met Thr Cys Asp Asn Glu Val Glu Leu Lys Lys Ile Ala Arg 
     130                135                140
Asn His Pro Asn Ala Lys Val Leu Leu His Ile Ala Thr Glu Asp Asn 
 145                150                155                160
Ile Gly Gly Glu Asp Gly Asn Met Lys Phe Gly Thr Thr Leu Lys Asn 
                 165                170                175
Cys Arg His Leu Leu Glu Cys Ala Lys Glu Leu Asp Val Gln Ile Ile 
             180                185                190
Gly Val Lys Phe His Ile Ser Ser Ala Cys Lys Glu Tyr Gln Val Tyr 
         195                200                205
Val His Ala Leu Ser Asp Ala Arg Cys Val Phe Asp Met Ala Gly Glu 
     210                215                220
Phe Gly Phe Thr Met Asn Met Leu Asp Ile Gly Gly Gly Phe Thr Gly 
 225                230                235                240
Thr Glu Ile Gln Leu Glu Glu Val Asn His Val Ile Ser Pro Leu Leu 
                 245                250                255
Asp Ile Tyr Phe Pro Glu Gly Ser Gly Ile Gln Ile Ile Ser Glu Pro 
             260                265                270
Gly Ser Tyr Tyr Val Ser Ser Ala Phe Thr Leu Ala Val Asn Ile Ile 
         275                280                285
Ala Lys Lys Val Val Glu Asn Asp Lys Leu Ser Ser Gly Val Glu Lys 
     290                295                300
Asn Gly Ser Asp Glu Pro Ala Phe Val Tyr Tyr Met Asn Asp Gly Val 
 305                310                315                320
Tyr Gly Ser Phe Ala Ser Lys Leu Ser Glu Asp Leu Asn Thr Val Pro 
                 325                330                335
Glu Val His Lys Lys Tyr Lys Glu Asp Glu Pro Leu Phe Thr Ser Ser 
             340                345                350
Leu Trp Gly Pro Ser Cys Asp Glu Leu Asp Gln Ile Val Glu Ser Cys 
         355                360                365
Leu Leu Pro Glu Leu Ser Val Gly Asp Trp Leu Ile Phe Asp Asn Met 
     370                375                380
Gly Ala Asp Ser Leu His Gly Pro Ser Ala Phe Ser Asp Thr Gln Arg 
 385                390                395                400
Pro Ala Ile Tyr Phe Met Met Ser Leu Ser Asp Trp Tyr Glu Met Gln 
                 405                410                415
Asp Ala Gly Ile Thr Ser Asp Ala Met Met Lys Asn Phe Phe Phe Ala 
             420                425                430
Pro Ser Cys Ile Gln Leu Ser Gln Glu Asp Asn Phe Ser Thr Glu Ala 
         435                440                445



<210> 2320
<211> 2619
<212> DNA
<213> Homo sapiens
<308> D88674
<400> 2320

agtttttcc  tttttcttc  gccgtcgcc  tctctgcct  ttctcatcc  ttctcgctc  60
gctgctctg  agtgtgacg  gtccgaatc  tcttcccac  cagcccgcg  ctttcttct  120
ttgcctgcg  tgttctatt  ctccttcgg  cgccgccgc  actgctgca  acagctggt  180
tcggtgccg  gcttttacc  ccaagtcgt  cccgcagcc  atggcccag  ccgccttgg  240
tatttctgc  caaggtaac  acatccctc  ttaaaaatt  cgccgaaaa  gagaagacg  300
tttacccga  tctttgggc  gttatctca  ggcgaactt  ctgaccaag  atacaacta  360
ccagagggc  taggagaag  gctgtatag  gagcagttc  acttcaacg  tgagccacc  420
tgggaacct  gctgatgat  ggggggttc  atctcccaa  ttgtccatg  aggtcttca  480
ttcagaaat  caagactca  attcatcca  cttggtgtc  agtgggctg  tgctgccag  540
attatcttg  gattatttg  gagatgtat  agtttcttc  gaagtacaa  caactgtag  600
agcctttgt  gcagtttgt  gcatattct  aggacccag  cataggctt  gtggcccgt  660
tcttgtctt  cctggttta  gactttcgg  tttgtggaa  acggctgag  tgaaaggat  720
tattgatga  gcaaactac  ccgttggcc  gttggatga  ggaacagac  ttggaaatg  780
tattgataa  tatgtttat  aacataccc  gacagggaa  aatgcattt  ttgtgggag  840
tcttggaaa  attgtgaag  aacacagtc  atggcagaa  gtagtggct  agataaagc  900
attctacac  gtgaagtgc  actctgctc  agctgtact  gagattttg  cagctcttg  960
aaccggatt  gcttgttcc  gtaaaaatg  aatggcttt  gtgcaagag  tgggtgtac  1020
tccagaaaa  attatttac  taagtcctt  caagcaagt  tctcagata  agtatgcag  1080
aaaagttgg  gtgaatatc  tgacatgtg  caatgaaat  gaattgaag  aaattgcac  1140
taatcaccc  aatgccaag  tcttactac  tattgcaac  gaagataat  ttggaggtg  1200
agagggtaa  atgaagttt  gcactaccc  gaagaactg  aggcatctc  tggaatgtg  1260
taaggaact  gatgtccaa  taattgggg  taaatttca  gtttcgagt  cttgcaaag  1320
atctcaagt  tatgtacat  ctctatctg  tgctcgatg  gtgtttgac  tggctggag  1380
aattggctt  acgatgaac  tgttagaca  tggtggagg  ttcacggga  ctgaatttc  1440
attggaaga  gttaatcat  ttatcagcc  tctgttgga  atctacttt  ctgaaggat  1500
tggtgttaa  ataatttca  aacccggaa  ctactatgt  tcttctgca  ttacactcg  1560
agttaatat  atagcaaag  aagttgttg  aaatgataa  tttccctct  gagtagaaa  1620
aaccggaag  gatgaacca  ccttcatgt  ttatatgaa  gatggtgtt  atggttctt  1680
tgcaagtaa  ctgtctgag  acttaaata  cattccaga  gttcacaag  aatacaagg  1740
agatgagcc  ctgtttaca  gcagccttt  gggtccatc  tgtgatgag  ttgatcaaa  1800
tgtggaaag  tgtcttctt  ctgagctga  tgtgggaga  tggcttatc  ttgataaca  1860
gggagcaga  tctttccat  aaccatctg  ttttaatga  tttcagagg  cagccattt  1920
ttacatgat  tcattcagt  attggtatg  gatgcaaga  gctggaatt  cttcagact  1980
aatgatgaa  aacttcttc  ttgtgcctt  ttgcattca  ctgagccaa  aagacagct  2040
ttccgctga  gcttaaaca  gcattaacg  ttctttaga  ctgaagttg  aggttaagc  2100
tgtctggtc  acattccag  gtggaaaaa  aatttaaac  atcttattc  cttaattct  2160
ttggcaaca  aaactatta  taatagcta  ttgggacca  acaaaatca  ctttcatct  2220
taattcatt  gggataatg  gagatttag  taatgtatc  agatttaaa  ctaccagtt  2280
gtcctaccc  ttaagcgtt  aaaataaaa  atgcaacaa  atggatgac  tagtggaga  2340
ggaagccca  taattgggt  ccccattaa  tcgtttaca  acaagaaca  agtttttat  2400
ctaaggatt  gtgtttaaa  tcttgtaaa  ttcatgtct  tcacccaga  atatcaaat  2460
ttagaagac  agtgtgact  cattagata  cgtttagtg  atttagaat  tgtaaattt  2520
tgctttgaa  tgtagttta  taaatgtaa  attgcatca  agtatttgt  gacctaatg  2580
aacccttgt  tgattgcaa  aaaattttg  gtagatttt  2619



<210> 2321
<211> 448
<212> PRT
<213> Homo sapiens
<308> O14977
<400> 2321

Met Lys Gly Phe Ile Asp Asp Ala Asn Tyr Ser Val Gly Leu Leu Asp 
  1               5                  10                  15
Glu Gly Thr Asp Leu Gly Asn Val Ile Asp Asn Tyr Val Tyr Glu His 
             20                  25                  30
Thr Leu Thr Gly Lys Asn Ala Phe Phe Val Gly Asp Leu Gly Lys Ile 
         35                  40                  45
Val Lys Lys His Ser Gln Trp Gln Asn Val Val Ala Gln Ile Lys Pro 
     50                  55                  60
Phe Tyr Thr Val Lys Cys Asn Ser Ala Pro Ala Val Leu Glu Ile Leu 
 65                  70                  75                  80
Ala Ala Leu Gly Thr Gly Phe Ala Cys Ser Ser Lys Asn Glu Met Ala 
                 85                  90                  95
Leu Val Gln Glu Leu Gly Val Pro Pro Glu Asn Ile Ile Tyr Ile Ser 
             100                105                110
Pro Cys Lys Gln Val Ser Gln Ile Lys Tyr Ala Ala Lys Val Gly Val 
         115                120                125
Asn Ile Leu Thr Cys Asp Asn Glu Ile Glu Leu Lys Lys Ile Ala Arg 
     130                135                140
Asn His Pro Asn Ala Lys Val Leu Leu His Ile Ala Thr Glu Asp Asn 
 145                150                155                160
Ile Gly Gly Glu Glu Gly Asn Met Lys Phe Gly Thr Thr Leu Lys Asn 
                 165                170                175
Cys Arg His Leu Leu Glu Cys Ala Lys Glu Leu Asp Val Gln Ile Ile 
             180                185                190
Gly Val Lys Phe His Val Ser Ser Ala Cys Lys Glu Ser Gln Val Tyr 
         195                200                205
Val His Ala Leu Ser Asp Ala Arg Cys Val Phe Asp Met Ala Gly Glu 
     210                215                220
Ile Gly Phe Thr Met Asn Met Leu Asp Ile Gly Gly Gly Phe Thr Gly 
 225                230                235                240
Thr Glu Phe Gln Leu Glu Glu Val Asn His Val Ile Ser Pro Leu Leu 
                 245                250                255
Asp Ile Tyr Phe Pro Glu Gly Ser Gly Val Lys Ile Ile Ser Glu Pro 
             260                265                270
Gly Ser Tyr Tyr Val Ser Ser Ala Phe Thr Leu Ala Val Asn Ile Ile 
         275                280                285
Ala Lys Lys Val Val Glu Asn Asp Lys Phe Pro Ser Gly Val Glu Lys 
     290                295                300
Thr Gly Ser Asp Glu Pro Ala Phe Met Tyr Tyr Met Asn Asp Gly Val 
 305                310                315                320
Tyr Gly Ser Phe Ala Ser Lys Leu Ser Glu Asp Leu Asn Thr Ile Pro 
                 325                330                335
Glu Val His Lys Lys Tyr Lys Glu Asp Glu Pro Leu Phe Thr Ser Ser 
             340                345                350
Leu Trp Gly Pro Ser Cys Asp Glu Leu Asp Gln Ile Val Glu Ser Cys 
         355                360                365
Leu Leu Pro Glu Leu Asn Val Gly Asp Trp Leu Ile Phe Asp Asn Met 
     370                375                380
Gly Ala Asp Ser Phe His Glu Pro Ser Ala Phe Asn Asp Phe Gln Arg 
 385                390                395                400
Pro Ala Ile Tyr Tyr Met Met Ser Phe Ser Asp Trp Tyr Glu Met Gln 
                 405                410                415
Asp Ala Gly Ile Thr Ser Asp Ser Met Met Lys Asn Phe Phe Phe Val 
             420                425                430
Pro Ser Cys Ile Gln Leu Ser Gln Glu Asp Ser Phe Ser Ala Glu Ala 
         435                440                445



<210> 2322
<211> 3324
<212> DNA
<213> Rattus norvegicus
<308> D90038
<400> 2322

gaattccag  gcggctcgc  cgccctgcc  gtgccatgg  ggccttcag  aagtacttg  60
cggcgcgga  ctcctcgct  gcgggggcc  cgttcctgc  gttctgcct  ctccacaag  120
ggcgtcgcg  cctcggcct  cacggtaag  aaagtggaa  accgccatt  cagaataat  180
agaaagaag  aaagaaaga  cgagctgtg  tggacaaag  gtttttatc  aggctctca  240
agatcctaa  aattatggt  cctagaaca  tttgtaaag  gacagggta  ttgatactt  300
ttgctgtta  gctggtatc  cgaacatac  gtgatgttt  gatgattca  aatggcaca  360
tgattgaaa  tggcatcat  ggtcgtagc  gtaaagatt  caagagata  ttattcaac  420
tcatcgctg  catgcctct  atctctctg  ttaataact  cttgaagta  gggttaaat  480
agctcaaac  gtgcttccg  gtgcggctc  ctagatacc  ctatgagga  tatctccaa  540
ccttcacct  ctataaaat  ggcaacctg  ataacagaa  agcaaaccc  gaccagctg  600
ttacacaag  tgtagaaaa  ttttgtaac  gtgtagttg  tctttattc  aatcttagt  660
agccatttt  agacatagt  ttgtatatt  tcaagttaa  aagtgcaat  ggagctcag  720
gcccggcaa  catgatggc  tacttgctt  tttctgggc  attcctaac  cgactcaga  780
gacccatcg  taaaatgac  attatggag  agaagtatg  aggagaata  agattcgtt  840
attcacggc  tatcactaa  agtgaagaa  ttgcctttt  caatgggaa  aaacgagaa  900
agcagacaa  ccactctgt  ttccgaaaa  tggtggaac  cctacataa  ttcattttc  960
tccggtttt  tatgggttt  attgatagc  tcattgcca  atatattgc  actgtagtt  1020
ggtacctgg  tgtcagtcg  ccgttccta  acctggcgc  tccgcgaca  cttcacagc  1080
cccactcag  gctgctgga  gattactac  aaagtggaa  aatgctttt  agaatgtct  1140
aagctttgg  gcggatagt  ttggctggg  gtgaaatga  tagattggc  ggttttacg  1200
ctcggatta  ggaattaat  caagtacta  aggatttaa  tcatggcaa  tatgaacgt  1260
caatggtgt  acaacagga  aagggtatt  aaggagcac  agctagtcc  ttgatacct  1320
gtgctggag  aatcatcaa  gcagacaac  ttataaagt  tgatcatgt  cctttagca  1380
caccaaatg  agatatctt  atccaagac  ttagttttg  agttcgatc  ggggccaac  1440
ttctcattt  tggtccaaa  ggctgtgga  agagctccc  cttccgtgt  cttggtgaa  1500
tatggcctc  ctttggagg  catcttact  aacctgaga  aggaaagtt  ttttatgtt  1560
ctcagcgac  ctatatgac  ctgggaaca  tgagagacc  agtaatata  ccagatgga  1620
aggaggatc  gaagaagaa  gggatatct  accaagtgc  gaaggggta  ttggacaat  1680
tacagttgg  ccatatcct  gagcgggaa  gaggctggg  cagtgttca  gactggatg  1740
atgtactca  cggaggaga  aaacaaaga  tggcgatgg  aagattgtt  tatcataaa  1800
cccagtttg  cattctgga  gagtgcaca  gtgcagtta  tgtggatgt  gaagactac  1860
tttacagcc  ctgtcggaa  gttggcatc  ccctcttca  tgtctcaca  aggaaatcc  1920
tttggaaac  ccacgagta  tacctgcac  tggatggca  aggcaatta  gaattcaaa  1980
agatcacag  agacacagt  gagttcgga  catagagac  atctggaga  cttcacact  2040
cacaagaga  tgaatgaac  gaatgcatt  gtaaacaac  tgcattgta  aataaagtt  2100
agcttgttt  ttttaaaaa  acaaagcta  aaattgact  gatatagga  aattgaaac  2160
tgttaaaac  tttaatatt  tataggata  tgctaattg  gtatatgtt  gtttaatta  2220
taattatgt  ctaagaatg  ccttattct  gtggttaaa  aacctgcct  aattaaatt  2280
ggcttaaat  agtgtaacc  gattcatgg  atgtaaacc  tttgaagtc  gctaatttg  2340
cttttatag  tctgtcttt  tctttaatg  agaacccta  ttaaaactg  gtcattagc  2400
gtttattct  acaaagtag  cttgagttc  tttttgggt  ttttttttt  ttttttttt  2460
ttttttttt  tgccccatg  tagtgggaa  caaaccaat  acaatgttt  attggaaca  2520
attccatca  cacaggata  catttatta  acagtggcg  atttctcta  ctgctacat  2580
tattctcat  cctcataca  accttgagg  gcatttgat  ccaggagag  catttgggt  2640
ttctttagc  aaataataa  tgtacccgt  tcagtcttt  ggactgagt  gttctgaag  2700
ctctcgtgt  gacagcagt  tgtgcagtc  cttacagtc  gtgcctgct  cacatggta  2760
cagtcttac  agtgcttga  agctcagac  caccctgct  catgaagtt  gaggtctcg  2820
gagggtttt  gattttgtg  cgggaaccg  aaaggctcg  cagagtgtg  ctgtgtcat  2880
gtgagcacc  cgtggctgt  gaggcccga  atgaggtaa  gcactgagc  cacaacgcc  2940
ctgctgctg  ctgtggctg  gggttctta  aagtgctgg  ctttgtcat  ctcgtgggc  3000
aatgacatt  cctaggagc  gcctctgac  cctgtgcag  tgcgtctgt  tcagctctg  3060
ctccctgga  ccacgagtg  ctttgcaca  aggagggct  agagcggac  tgatcagta  3120
gtcgtcgtg  atcagtttg  ttgagtggg  tcggaatgg  ccttatcac  atggttttg  3180
ttcttcgta  ctcataatc  ctggctacc  ggataaccc  gatgtattg  ttccgtgaa  3240
acatcacat  caatcttac  atgtctcct  agcaaacgt  tgtacttat  ttctgttca  3300
attaaaaaa  aaaaaaagg  attc  3324



<210> 2323
<211> 658
<212> PRT
<213> Rattus norvegicus
<308> P16970
<400> 2323

Ala Ala Phe Ser Lys Tyr Leu Thr Ala Arg Asn Ser Ser Leu Ala Gly 
  1               5                  10                  15
Ala Ala Phe Leu Leu Phe Cys Leu Leu His Lys Arg Arg Arg Ala Leu 
             20                  25                  30
Gly Leu His Gly Lys Lys Ser Gly Lys Pro Pro Leu Gln Asn Asn Glu 
         35                  40                  45
Lys Glu Gly Lys Lys Glu Arg Ala Val Val Asp Lys Val Phe Leu Ser 
     50                  55                  60
Arg Leu Ser Gln Ile Leu Lys Ile Met Val Pro Arg Thr Phe Cys Lys 
 65                  70                  75                  80
Glu Thr Gly Tyr Leu Ile Leu Ile Ala Val Met Leu Val Ser Arg Thr 
                 85                  90                  95
Tyr Cys Asp Val Trp Met Ile Gln Asn Gly Thr Leu Ile Glu Ser Gly 
             100                105                110
Ile Ile Gly Arg Ser Ser Lys Asp Phe Lys Arg Tyr Leu Phe Asn Phe 
         115                120                125
Ile Ala Ala Met Pro Leu Ile Ser Leu Val Asn Asn Phe Leu Lys Tyr 
     130                135                140
Gly Leu Asn Glu Leu Lys Leu Cys Phe Arg Val Arg Leu Thr Arg Tyr 
 145                150                155                160
Leu Tyr Glu Glu Tyr Leu Gln Ala Phe Thr Tyr Tyr Lys Met Gly Asn 
                 165                170                175
Leu Asp Asn Arg Ile Ala Asn Pro Asp Gln Leu Leu Thr Gln Asp Val 
             180                185                190
Glu Lys Phe Cys Asn Ser Val Val Asp Leu Tyr Ser Asn Leu Ser Lys 
         195                200                205
Pro Phe Leu Asp Ile Val Leu Tyr Ile Phe Lys Leu Thr Ser Ala Ile 
     210                215                220
Gly Ala Gln Gly Pro Ala Ser Met Met Ala Tyr Leu Leu Val Ser Gly 
 225                230                235                240
Leu Phe Leu Thr Arg Leu Arg Arg Pro Ile Gly Lys Met Thr Ile Met 
                 245                250                255
Glu Gln Lys Tyr Glu Gly Glu Tyr Arg Phe Val Asn Ser Arg Leu Ile 
             260                265                270
Thr Asn Ser Glu Glu Ile Ala Phe Tyr Asn Gly Asn Lys Arg Glu Lys 
         275                280                285
Gln Thr Ile His Ser Val Phe Arg Lys Leu Val Glu His Leu His Asn 
     290                295                300
Phe Ile Phe Phe Arg Phe Ser Met Gly Phe Ile Asp Ser Ile Ile Ala 
 305                310                315                320
Lys Tyr Ile Ala Thr Val Val Gly Tyr Leu Val Val Ser Arg Pro Phe 
                 325                330                335
Leu Asp Leu Ala His Pro Arg His Leu His Ser Thr His Ser Glu Leu 
             340                345                350
Leu Glu Asp Tyr Tyr Gln Ser Gly Arg Met Leu Leu Arg Met Ser Gln 
         355                360                365
Ala Leu Gly Arg Ile Val Leu Ala Gly Arg Glu Met Thr Arg Leu Ala 
     370                375                380
Gly Phe Thr Ala Arg Ile Thr Glu Leu Met Gln Val Leu Lys Asp Leu 
 385                390                395                400
Asn His Gly Lys Tyr Glu Arg Thr Met Val Ser Gln Gln Asp Lys Gly 
                 405                410                415
Ile Glu Gly Ala Gln Ala Ser Pro Leu Ile Pro Gly Ala Gly Glu Ile 
             420                425                430
Ile Asn Ala Asp Asn Ile Ile Lys Phe Asp His Val Pro Leu Ala Thr 
         435                440                445
Pro Asn Gly Asp Ile Leu Ile Gln Asp Leu Ser Phe Glu Val Arg Ser 
     450                455                460
Gly Ala Asn Val Leu Ile Cys Gly Pro Asn Gly Cys Gly Lys Ser Ser 
 465                470                475                480
Leu Phe Arg Val Leu Gly Glu Leu Trp Pro Leu Phe Gly Gly His Leu 
                 485                490                495
Thr Lys Pro Glu Arg Gly Lys Leu Phe Tyr Val Pro Gln Arg Pro Tyr 
             500                505                510
Met Thr Leu Gly Thr Leu Arg Asp Gln Val Ile Tyr Pro Asp Gly Lys 
         515                520                525
Glu Asp Gln Lys Lys Lys Gly Ile Ser Asp Gln Val Leu Lys Gly Tyr 
     530                535                540
Leu Asp Asn Val Gln Leu Gly His Ile Leu Glu Arg Glu Gly Gly Trp 
 545                550                555                560
Asp Ser Val Gln Asp Trp Met Asp Val Leu Ser Gly Gly Glu Lys Gln 
                 565                570                575
Arg Met Ala Met Ala Arg Leu Phe Tyr His Lys Pro Gln Phe Ala Ile 
             580                585                590
Leu Asp Glu Cys Thr Ser Ala Val Ser Val Asp Val Glu Asp Tyr Ile 
         595                600                605
Tyr Ser His Cys Arg Lys Val Gly Ile Thr Leu Phe Thr Val Ser His 
     610                615                620
Arg Lys Ser Leu Trp Lys His His Glu Tyr Tyr Leu His Met Asp Gly 
 625                630                635                640
Arg Gly Asn Tyr Glu Phe Lys Lys Ile Thr Glu Asp Thr Val Glu Phe 
                 645                650                655
Gly Ser 
             660



<210> 2324
<211> 949
<212> DNA
<213> Homo sapiens
<308> BC009712
<400> 2324

cggacgcgt  ggcggacgc  tgggtcgcc  gctcgctgg  accggcagt  ccatggcgg  60
cttcagcaa  tacttgacg  cgcgaaact  ctcgctggc  ggtgccgcg  tcctgctgc  120
ctgcctgct  cacaagcgg  gccgcgccc  cggcctgca  ggtaagaaa  gtggaaaac  180
accattaca  aacaatgag  aagagggga  aaaggagcg  gctgtggtg  acaaggtgt  240
tttctcaag  ctcatacag  ttctgaaaa  catggtccc  agaacattt  gtaaagaga  300
aggttactt  gtacttatt  ctgttatgc  ggtgtctcg  acatattgt  atgtttgga  360
gattcaaaa  gggacacta  ttgaaagtg  tatcattgg  cgtagcagg  aagatttca  420
gagatactt  ctcaacttc  tcgctgcca  gcctcttat  tctctggtt  ataacttct  480
gaagtatgg  ttaaatgag  ttaaactgt  cttccgagt  aggctcact  aatacctct  540
tgaggagta  cttcaagct  tcacatatt  taaaatggg  aatctggac  acagaatag  600
taatccaga  cagctgctt  cacaagatg  agaaaaatt  tgtaacagt  tagtcgatc  660
gtattcaaa  cttagtaag  catttttag  catagtttt  tatatcttt  agttaacga  720
tgcaattgg  gctcaggta  ttggaaaaa  tttgtggca  taaaaacca  acaaatgta  780
tggccaggc  tggtggctc  tgcctgtaa  cccagcact  tgggaggct  agatgggag  840
atcgcttga  tccaggagt  cgagacaag  ctggacaaa  agcgagacc  gcttcttta  900
aaaataata  taaaacaga  gttcttaaa  catgaaaaa  aaaaaaaaa  949



<210> 2325
<211> 659
<212> PRT
<213> Homo sapiens
<308> P28288
<400> 2325

Met Ala Ala Phe Ser Lys Tyr Leu Thr Ala Arg Asn Ser Ser Leu Ala 
  1               5                  10                  15
Gly Ala Ala Phe Leu Leu Leu Cys Leu Leu His Lys Arg Arg Arg Ala 
             20                  25                  30
Leu Gly Leu His Gly Lys Lys Ser Gly Lys Pro Pro Leu Gln Asn Asn 
         35                  40                  45
Glu Lys Glu Gly Lys Lys Glu Arg Ala Val Val Asp Lys Val Phe Phe 
     50                  55                  60
Ser Arg Leu Ile Gln Ile Leu Lys Ile Met Val Pro Arg Thr Phe Cys 
 65                  70                  75                  80
Lys Glu Thr Gly Tyr Leu Val Leu Ile Ala Val Met Leu Val Ser Arg 
                 85                  90                  95
Thr Tyr Cys Asp Val Trp Met Ile Gln Asn Gly Thr Leu Ile Glu Ser 
             100                105                110
Gly Ile Ile Gly Arg Ser Arg Lys Asp Phe Lys Arg Tyr Leu Leu Asn 
         115                120                125
Phe Ile Ala Ala Met Pro Leu Ile Ser Leu Val Asn Asn Phe Leu Lys 
     130                135                140
Tyr Gly Leu Asn Glu Leu Lys Leu Cys Phe Arg Val Arg Leu Thr Lys 
 145                150                155                160
Tyr Leu Tyr Glu Glu Tyr Leu Gln Ala Phe Thr Tyr Tyr Lys Met Gly 
                 165                170                175
Asn Leu Asp Asn Arg Ile Ala Asn Pro Asp Gln Leu Leu Thr Gln Asp 
             180                185                190
Val Glu Lys Phe Cys Asn Ser Val Val Asp Leu Tyr Ser Asn Leu Ser 
         195                200                205
Lys Pro Phe Leu Asp Ile Val Leu Tyr Ile Phe Lys Leu Thr Ser Ala 
     210                215                220
Ile Gly Ala Gln Gly Pro Ala Ser Met Met Ala Tyr Leu Val Val Ser 
 225                230                235                240
Gly Leu Phe Leu Thr Arg Leu Arg Arg Pro Ile Gly Lys Met Thr Ile 
                 245                250                255
Thr Glu Gln Lys Tyr Glu Gly Glu Tyr Arg Tyr Val Asn Ser Arg Leu 
             260                265                270
Ile Thr Asn Ser Glu Glu Ile Ala Phe Tyr Asn Gly Asn Lys Arg Glu 
         275                280                285
Lys Gln Thr Val His Ser Val Phe Arg Lys Leu Val Glu His Leu His 
     290                295                300
Asn Phe Ile Leu Phe Arg Phe Ser Met Gly Phe Ile Asp Ser Ile Ile 
 305                310                315                320
Ala Lys Tyr Leu Ala Thr Val Val Gly Tyr Leu Val Val Ser Arg Pro 
                 325                330                335
Phe Leu Asp Leu Ser His Pro Arg His Leu Lys Ser Thr His Ser Glu 
             340                345                350
Leu Leu Glu Asp Tyr Tyr Gln Ser Gly Arg Met Leu Leu Arg Met Ser 
         355                360                365
Gln Ala Leu Gly Arg Ile Val Leu Ala Gly Arg Glu Met Thr Arg Leu 
     370                375                380
Ala Gly Phe Thr Ala Arg Ile Thr Glu Leu Met Gln Val Leu Lys Asp 
 385                390                395                400
Leu Asn His Gly Lys Tyr Glu Arg Thr Met Val Ser Gln Gln Glu Lys 
                 405                410                415
Gly Ile Glu Gly Val Gln Val Ile Pro Leu Ile Pro Gly Ala Gly Glu 
             420                425                430
Ile Ile Ile Ala Asp Asn Ile Ile Lys Phe Asp His Val Pro Leu Ala 
         435                440                445
Thr Pro Asn Gly Asp Val Leu Ile Arg Asp Leu Asn Phe Glu Val Arg 
     450                455                460
Ser Gly Ala Asn Val Leu Ile Cys Gly Pro Asn Gly Cys Gly Lys Ser 
 465                470                475                480
Ser Leu Phe Arg Val Leu Gly Glu Leu Trp Pro Leu Phe Gly Gly Arg 
                 485                490                495
Leu Thr Lys Pro Glu Arg Gly Lys Leu Phe Tyr Val Pro Gln Arg Pro 
             500                505                510
Tyr Met Thr Leu Gly Thr Leu Arg Asp Gln Val Ile Tyr Pro Asp Gly 
         515                520                525
Arg Glu Asp Gln Lys Arg Lys Gly Ile Ser Asp Leu Val Leu Lys Glu 
     530                535                540
Tyr Leu Asp Asn Val Gln Leu Gly His Ile Leu Glu Arg Glu Gly Gly 
 545                550                555                560
Trp Asp Ser Val Gln Asp Trp Met Asp Val Leu Ser Gly Gly Glu Lys 
                 565                570                575
Gln Arg Met Ala Met Ala Arg Leu Phe Tyr His Lys Pro Gln Phe Ala 
             580                585                590
Ile Leu Asp Glu Cys Thr Ser Ala Val Ser Val Asp Val Glu Gly Tyr 
         595                600                605
Ile Tyr Ser His Cys Arg Lys Val Gly Ile Thr Leu Phe Thr Val Ser 
     610                615                620
His Arg Lys Ser Leu Trp Lys His His Glu Tyr Tyr Leu His Met Asp 
 625                630                635                640
Gly Arg Gly Asn Tyr Glu Phe Lys Gln Ile Thr Glu Asp Thr Val Glu 
                 645                650                655
Phe Gly Ser 
             660



<210> 2326
<211> 3657
<212> DNA
<213> Rattus norvegicus
<308> D90109
<400> 2326

ccaacacag  actatggaa  tccacgaat  gttccggta  tttcgaatg  cagagctga  60
tgacattcg  cagtacgtg  gtacccttc  aaccaacac  ctcatgggc  tcggggctt  120
tgcagcgct  accaccttc  ggtatgcca  ccggccgaa  gccctgaag  caccatgtg  180
tctgtccat  cagtctgtg  aagtaacgg  tactactga  ggtgtccga  gatcagcag  240
ccttgagga  gacaagctc  tgctgtact  ctacgacga  gtcagaacg  tgtacgatg  300
cttccagag  gggattcag  tgtcaaatg  tggcccttg  ttaggttct  gaaagccaa  360
ccagccata  gagtggatt  cttacaaac  ggttgcaga  atggctgag  gcataggct  420
ggcgctgat  cagaagggt  tcaaacctt  ctcagagca  ttcatcggc  tcttttctc  480
gaacagacc  gagtgggtg  ccatcgagc  ggggtgctt  acttactcc  tggtggttg  540
tccgctcta  gacacgctt  gaaccgacg  catcaccta  atagtgaac  aagctgaac  600
ctctgtgat  tttgctgac  agccagaaa  agccaaact  ttattagaa  gtgtagaaa  660
taagttaac  ccatgcctt  aaatcatag  catcatgga  tcctacgac  atgatctgg  720
ggaacgcgg  cagaagtgt  gggtggaaa  catcggcct  aaagctctg  aggatcttg  780
aagagtgaa  agaacgaaa  ccaagcctc  agaacctga  gatcttgcg  taatctgtt  840
cacaagtgg  actacaggc  accccaaag  agcaatggt  acccaccaa  acattatga  900
cgattgctc  ggttttata  aagcgacgg  gagtgcatt  atcgcttcc  cagaggatg  960
tctgatatc  ttcttgcct  tcgcccata  gtttgagac  gttgtagag  gtgtaatgc  1020
atgtcatgg  gctaagata  gatttttcc  aggagacat  aggctgctt  tggatgacc  1080
caaggtgct  cagcctacc  tcttccctg  ggttccgag  ctgctaaac  ggatgtttg  1140
cagaatttt  ggacaagca  acacgtcag  gaagcgatg  ctgttggat  ttgcctcca  1200
aaggaaaga  gcggagctt  gcagtggca  cgtcagaaa  aacagcctg  gggataaac  1260
catctttca  aagatacag  cgagcctgg  cgggaaagt  cggctgatg  tcacaggag  1320
agccccagt  tctgccaca  tgctgacgt  tctgagggc  gctctcggc  gtcagttct  1380
tgaaggcta  ggacagacc  agtgcaccg  tggttgctg  ctgagcttg  ctggagact  1440
gacagcagg  catgttggt  cccccatgc  ttgcaatta  atcaagctt  tagatgtgg  1500
agatatgaa  taccaggct  ccaagggcg  gggtgaggt  tgtgtgaaa  gggcaaatg  1560
gttcaaagg  tacttgaaa  acccagcaa  aacagctga  gccctagat  aagatggtt  1620
gttacacac  ggggacatt  gaaaatggc  gccaaatgg  accttgaag  ttatcgaca  1680
gaaaaagca  atatttaaa  tagcccaag  agagtacat  gctccagaa  agatcgaaa  1740
tatctacct  cggagcgaa  ccgtggccc  ggtgtttgt  catggagaa  gcttgcagg  1800
ctttctcat  gccattgta  tacctgatg  ggagatcct  ccttcctgg  cacagaaga  1860
aggatttca  gggtccttt  aagaactgt  caggaacaa  gatatcaat  aagctatcc  1920
ggaagacat  gtgaaactt  ggaagaatg  tggtttgaa  ccatttgaa  aggtcaaag  1980
cattgctgt  cacccggaa  tattttcta  tgacaatgg  ctcctgact  caacactga  2040
ggcaaaaag  ccagagctg  ggaactatt  caggtcaca  atagatgaa  tgtactcca  2100
catcaagat  taacatgag  aagaatcct  agaggaaat  gcgcacctc  acaatcctc  2160
tcgtaccaa  ggcctttga  ttggtaact  tgcctgcag  gagtgtggg  aaggaaatg  2220
catgctgga  ttgtgcaca  ggtcttacc  tagggatag  agagggcac  gaacactgc  2280
ttacagtca  ctgtgttgt  gcccatgat  ctggggata  acagtttcc  aaacgagcc  2340
taaacattg  aaaggggaa  ccataaaag  gctaagtta  ttaagactt  aaccaataa  2400
gtgggtgtt  aaacttctg  ctcctgttt  tctaaccaa  gggttagga  ttactcttt  2460
tgatacgtc  gctgctggc  gcacaccct  cagccgtct  ctgctctga  gagtacagt  2520
cactggaag  aagctaccc  tttaagagc  actgtccag  ctgaagaaa  tcacagtgg  2580
ccagagatt  ctcttctta  ccccttccc  ttgtccctt  ccctcacca  tcacatgca  2640
tacatttat  tgacccttc  ggtttgtaa  ggttccaaa  ggtccctgt  gtgcctgct  2700
gtaacctcg  gtttccagt  cactaaaga  cagatcctc  tcagaacaa  gcgggtacc  2760
agtctcaga  aaggaaaaa  aaaaaaagg  ggctcctgc  ttgagccag  aacttgcag  2820
ctcacacag  tgtcctcag  ctccgctcc  tctctgctc  ctgcccctc  cattcttcc  2880
aggggttat  agaaaccct  ccttagact  tgcagtgaa  atggtgttc  gaagaatga  2940
ctggatggg  catgctcaa  tgtgattcc  cccccgctg  ccactcgct  gctcgtcgt  3000
gaaccagcc  gtatctgca  cggcctctg  gctccaaat  tggttttct  gcaaatgct  3060
atgtggtga  caacttgct  tgttttctt  ccctcccag  taaactcag  cacagcatg  3120
cttcagaag  atctaggca  ttggtatac  tgggtactt  ttaaagtgg  cagtaataa  3180
taaatgtcc  tattataaa  ctacctgat  tatgtgaaa  gcatttgat  agccaaaaa  3240
ctggggtgt  gaaatctgg  ggaaaaaaa  tcatatcct  ggatcaact  cccaaggta  3300
attttttaa  ttaatttgg  aaatgaaca  catttcact  tgccgcgag  cttggccac  3360
tttgaccta  ttgagctgt  tatacattt  aagccactg  tgttggctg  gtgacagtg  3420
gtgtatctt  aagcacaac  gggtttgca  taaagaatc  tcattgtaa  aacactatt  3480
ggtagccta  cttcatttt  gtattctta  ctgcacagg  agtcgataa  ttgtcacaa  3540
ggggttttg  atgtttgct  tcagtgttg  ctatttcta  gttttataa  ccaaaacag  3600
atttccaaa  acaatgaag  aaaccaaaa  aaatatttc  gcatttgga  tgagtgg  3657



<210> 2327
<211> 699
<212> PRT
<213> Rattus norvegicus
<308> P18163
<400> 2327

Met Glu Val His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Ile 
  1               5                  10                  15
Asp Ile Arg Gln Tyr Val Arg Thr Leu Pro Thr Asn Thr Leu Met Gly 
             20                  25                  30
Phe Gly Ala Phe Ala Ala Leu Thr Thr Phe Trp Tyr Ala Thr Arg Pro 
         35                  40                  45
Lys Ala Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val 
     50                  55                  60
Thr Gly Thr Thr Glu Gly Val Arg Arg Ser Ala Val Leu Glu Asp Asp 
 65                  70                  75                  80
Lys Leu Leu Leu Tyr Tyr Tyr Asp Asp Val Arg Thr Met Tyr Asp Gly 
                 85                  90                  95
Phe Gln Arg Gly Ile Gln Val Ser Asn Asp Gly Pro Cys Leu Gly Ser 
             100                105                110
Arg Lys Pro Asn Gln Pro Tyr Glu Trp Ile Ser Tyr Lys Gln Val Ala 
         115                120                125
Glu Met Ala Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys 
     130                135                140
Pro Cys Ser Glu Gln Phe Ile Gly Ile Phe Ser Gln Asn Arg Pro Glu 
 145                150                155                160
Trp Val Thr Ile Glu Gln Gly Cys Phe Thr Tyr Ser Met Val Val Val 
                 165                170                175
Pro Leu Tyr Asp Thr Leu Gly Thr Asp Ala Ile Thr Tyr Ile Val Asn 
             180                185                190
Lys Ala Glu Leu Ser Val Ile Phe Ala Asp Lys Pro Glu Lys Ala Lys 
         195                200                205
Leu Leu Leu Glu Gly Val Glu Asn Lys Leu Thr Pro Cys Leu Lys Ile 
     210                215                220
Ile Val Ile Met Asp Ser Tyr Asp Asn Asp Leu Val Glu Arg Gly Gln 
 225                230                235                240
Lys Cys Gly Val Glu Ile Ile Gly Leu Lys Ala Leu Glu Asp Leu Gly 
                 245                250                255
Arg Val Asn Arg Thr Lys Pro Lys Pro Pro Glu Pro Glu Asp Leu Ala 
             260                265                270
Ile Ile Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met 
         275                280                285
Val Thr His Gln Asn Ile Met Asn Asp Cys Ser Gly Phe Ile Lys Ala 
     290                295                300
Thr Glu Ser Ala Phe Ile Ala Ser Pro Glu Asp Val Leu Ile Ser Phe 
 305                310                315                320
Leu Pro Leu Ala His Met Phe Glu Thr Val Val Glu Cys Val Met Leu 
                 325                330                335
Cys His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu 
             340                345                350
Met Asp Asp Leu Lys Val Leu Gln Pro Thr Ile Phe Pro Val Val Pro 
         355                360                365
Arg Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Thr 
     370                375                380
Ser Val Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala 
 385                390                395                400
Glu Leu Arg Ser Gly Ile Val Arg Asn Asn Ser Leu Trp Asp Lys Leu 
                 405                410                415
Ile Phe His Lys Ile Gln Ser Ser Leu Gly Gly Lys Val Arg Leu Met 
             420                425                430
Ile Thr Gly Ala Ala Pro Val Ser Ala Thr Val Leu Thr Phe Leu Arg 
         435                440                445
Ala Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Thr Glu Cys 
     450                455                460
Thr Ala Gly Cys Cys Leu Ser Leu Pro Gly Asp Trp Thr Ala Gly His 
 465                470                475                480
Val Gly Ala Pro Met Pro Cys Asn Tyr Ile Lys Leu Val Asp Val Glu 
                 485                490                495
Asp Met Asn Tyr Gln Ala Ala Lys Gly Glu Gly Glu Val Cys Val Lys 
             500                505                510
Gly Ala Asn Val Phe Lys Gly Tyr Leu Lys Asp Pro Ala Arg Thr Ala 
         515                520                525
Glu Ala Leu Asp Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys 
     530                535                540
Trp Leu Pro Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile 
 545                550                555                560
Phe Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn 
                 565                570                575
Ile Tyr Leu Arg Ser Glu Ala Val Ala Gln Val Phe Val His Gly Glu 
             580                585                590
Ser Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Ile 
         595                600                605
Leu Pro Ser Trp Ala Gln Lys Arg Gly Phe Gln Gly Ser Phe Glu Glu 
     610                615                620
Leu Cys Arg Asn Lys Asp Ile Asn Lys Ala Ile Leu Glu Asp Met Val 
 625                630                635                640
Lys Leu Gly Lys Asn Ala Gly Leu Lys Pro Phe Glu Gln Val Lys Gly 
                 645                650                655
Ile Ala Val His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Thr 
             660                665                670
Pro Thr Leu Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser 
         675                680                685
Gln Ile Asp Glu Leu Tyr Ser Thr Ile Lys Ile 
     690                695



<210> 2328
<211> 3188
<212> DNA
<213> Homo sapiens
<308> NM_001995
<400> 2328

cgggcagtg  cagccggcg  ggatcgcgc  tccacggag  agaatcagc  tagagaact  60
tcaacacag  acaatgcaa  cccatgagc  gttccggta  tttcgaatg  cagagctgg  120
tgacttccg  cagtgcgtg  ctcttccga  caacacgct  atgggcttc  gagcttttt  180
cagacgact  accaccttc  ggcggccac  ccacccaaa  cccctgaag  cgccatggc  240
cctctccat  cagtcagtg  aagtggcgg  tagtggtgg  gcacgaaga  ccgcactac  300
tgacagcga  gagcccttg  tgtatttct  tgatgatgt  acaacatta  acgaaggtt  360
ccagagagg  atacaggtg  caaataatg  cccttgttt  ggctctcgg  aaccagacc  420
accctatga  tggctttca  ataaacagg  tgcagaatt  tcggagtgc  taggctcag  480
actgatcca  aagggcttc  agactgccc  agatcagtt  attggcatc  ttgctcaaa  540
tagacctga  tgggtgatt  ttgaacaag  atgctttgc  tattcgatg  tgatcgttc  600
actttatga  acccttgga  atgaagcca  cacgtacat  gtcaacaaa  ctgaactct  660
tctggtttt  gttgacaag  cagagaagg  caaactctt  ttagagggt  tagaaaata  720
gttaatacc  ggccttaaa  tcatagttg  catggactc  tacggcagt  aactggtgg  780
acgaggcca  aggtgtggg  tggaagtca  cagcatgaa  gcgatggag  acctgggaa  840
agccaacag  cggaagccc  agcctccag  acctgaaga  cttgcagta  tttgtttca  900
aagtggaac  acaggcaac  ccaaaggag  aatggtcac  caccgaaac  tagtgagcg  960
ttgttcagc  tttgtgaaa  caacagaga  tacagtcaa  ccttgccca  atgatactt  1020
gatatcttt  ttgcctctc  cccatatgt  tgagagagt  gtagagtgt  taatgctgt  1080
tcatggagc  aaaatcgga  ttttccaag  agatatcag  ctgctcatg  atgacctca  1140
ggtgcttca  cccactgtc  tccccgtgg  tccaagact  ctgaaccgg  tgtttgacc  1200
aattttcgg  caagcaaac  ccaccgtga  gcgatggct  ttggacttt  cctccaaga  1260
gaaagaagc  gacgttcgc  gcggcatca  cagaaacaa  agcctgtgg  accggctga  1320
cttccacaa  gtacagtcg  gcctgggcg  aagagtccg  ctgatggtg  caggagccg  1380
cccggtgtc  gccactgtg  tgacgttcc  cagagcagc  ctgggctgt  agttttatg  1440
aggatacgg  cagacagag  gcactgccg  gtgctgcct  accatgcct  gagactgga  1500
cacaggcca  gttggggcc  cgatgccgt  caatttgat  aaacttggt  ggcagttgg  1560
agaaatgaa  tacatggcg  ccgagggcg  gggcgaggt  tgtgtgaaa  ggccaaatg  1620
atttcaggg  tacttgaag  acccagcga  aacagcaga  gctttggac  aagacggct  1680
gttacacac  ggggacatc  gaaaatggt  accaaatgg  accttgaaa  ttatcgacc  1740
gaaaaagca  atatttaag  tggcacaag  agaatacat  gcccctgaa  agattgaaa  1800
tatctacat  cgaagtgag  ctgttgctc  ggtgtttgt  cacggagaa  gcctgcagg  1860
atttctcat  gcaattgtg  taccagatg  tgagacatt  tgttcctgg  cccaaaaga  1920
aggatttga  gggtcgttt  aggaactgt  cagaaataa  gatgtcaaa  aagctatcc  1980
cgaagatat  gtgagactt  ggaaggatt  tggtctgaa  ccatttgaa  aggtcaaag  2040
catcacatt  caccctgaa  tattttcta  cgacaatgg  cttctgact  caacaatga  2100
ggcgaaaag  ccagagctg  ggaactatt  caggtcgca  atagatgac  tctattcca  2160
catcaaggt  tagtgtgaa  aagaaagct  agaggaaat  gcacagttc  acaatctct  2220
ctcctgctg  tggccttca  gttgttaat  ttgaataca  caagtgtag  gaaggaagc  2280
ttctgtgtt  gacttgtcc  ttcggggtt  ttctcatag  aatgctaga  gaaacagaa  2340
actgcctta  agtcacctc  gtgttcaga  catgtttat  gtaatacac  cttccaaaa  2400
tagccttaa  aattgtaaa  ggatactat  aatgtgcta  ttatttgag  cttcctcag  2460
ttaaaaagt  ggttttaaa  cttctgtct  cctgttttt  taatcaagg  gttaggact  2520
tgctatctc  gagatgtct  ctacttcgt  gaaattctg  agctgtctg  tgctctaaa  2580
agtacagtg  tctagaggg  agtgttccc  ttaaaaata  gaacaactg  cctggctgg  2640
gatctcaca  gcggaccag  gatcttttt  aatccctgc  actgtccct  ctcacaggc  2700
ttcacagaa  ccttctgat  cgaagggtt  cgaaactca  gttcttctc  agtcccctg  2760
ggtttctgt  ggagcataa  gtttccagt  agcgggagg  cagatccaa  tcagaacca  2820
gcagataag  agcctctgg  aaatgggtg  tgcatcaga  cgcgtggat  ctctttcat  2880
gcagatgct  ttggactcg  ttctccagg  ctgattccc  gactccatc  tttttcagg  2940
ttatttaaa  atctgcctt  gattctata  tgaagacaa  catttcaag  aagagttac  3000
tggatcagc  atgctcagc  gtgacgcct  ataactgtc  actttatct  cactgaacc  3060
ctcactctg  gtaaaggcc  acggatttt  aatgtggtt  tcatatcaa  agatcatgt  3120
gggattaac  tgccttttt  cccaaaaaa  aaactctca  gcaaggcat  tcttttaaa  3180
ctattccg  3188



<210> 2329
<211> 699
<212> PRT
<213> Homo sapiens
<308> P41215
<400> 2329

Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val 
  1               5                  10                  15
Asp Phe Arg Gln Cys Val Thr Leu Pro Thr Asn Thr Leu Met Gly Phe 
             20                  25                  30
Gly Ala Phe Ser Arg Arg Leu Thr Thr Phe Trp Arg Pro Arg His Pro 
         35                  40                  45
Lys Pro Leu Lys Pro Pro Trp His Leu Ser Met Gln Ser Val Glu Val 
     50                  55                  60
Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu 
 65                  70                  75                  80
Pro Leu Val Tyr Phe Tyr Asp Asp Val Thr Thr Leu Tyr Glu Gly Phe 
                 85                  90                  95
Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg 
             100                105                110
Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Val Ala Glu 
         115                120                125
Leu Ser Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys Thr 
     130                135                140
Ala Pro Asp Gln Phe Ile Gly Ile Phe Ala Gln Asn Arg Pro Glu Trp 
 145                150                155                160
Val Ile Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro 
                 165                170                175
Leu Tyr Asp Thr Leu Gly Asn Glu Ala Ile Thr Tyr Ile Val Asn Lys 
             180                185                190
Ala Glu Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu 
         195                200                205
Leu Leu Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile 
     210                215                220
Val Val Met Asp Ser Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg 
 225                230                235                240
Cys Gly Val Glu Val Thr Ser Met Lys Ala Met Glu Asp Leu Gly Arg 
                 245                250                255
Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val 
             260                265                270
Ile Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Val 
         275                280                285
Thr His Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Thr 
     290                295                300
Glu Asn Thr Val Asn Pro Cys Pro Asp Asp Thr Leu Ile Ser Phe Leu 
 305                310                315                320
Pro Leu Ala His Met Phe Glu Arg Val Val Glu Cys Val Met Leu Cys 
                 325                330                335
His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met 
             340                345                350
Asp Asp Leu Lys Val Leu Gln Pro Thr Val Phe Pro Val Val Pro Arg 
         355                360                365
Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Thr Thr 
     370                375                380
Val Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala Asp 
 385                390                395                400
Val Arg Ser Gly Ile Ile Arg Asn Asn Ser Leu Trp Asp Arg Leu Ile 
                 405                410                415
Phe His Lys Val Gln Ser Ser Leu Gly Gly Arg Val Arg Leu Met Val 
             420                425                430
Thr Gly Ala Ala Pro Val Ser Ala Thr Val Leu Thr Phe Leu Arg Ala 
         435                440                445
Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr 
     450                455                460
Ala Gly Cys Cys Leu Thr Met Pro Gly Asp Trp Thr Thr Gly His Val 
 465                470                475                480
Gly Ala Pro Met Pro Cys Asn Leu Ile Lys Leu Gly Trp Gln Leu Glu 
                 485                490                495
Glu Met Asn Tyr Met Ala Ser Glu Gly Glu Gly Glu Val Cys Val Lys 
             500                505                510
Gly Pro Asn Val Phe Gln Gly Tyr Leu Lys Asp Pro Ala Lys Thr Ala 
         515                520                525
Glu Ala Leu Asp Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys 
     530                535                540
Trp Leu Pro Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile 
 545                550                555                560
Phe Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn 
                 565                570                575
Ile Tyr Met Arg Ser Glu Pro Val Ala Gln Val Phe Val His Gly Glu 
             580                585                590
Ser Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Thr 
         595                600                605
Leu Cys Ser Trp Ala Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu 
     610                615                620
Leu Cys Arg Asn Lys Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val 
 625                630                635                640
Arg Leu Gly Lys Asp Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly 
                 645                650                655
Ile Thr Leu His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Thr 
             660                665                670
Pro Thr Met Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser 
         675                680                685
Gln Ile Asp Asp Leu Tyr Ser Ile Ile Lys Val 
     690                695



<210> 2330
<211> 897
<212> DNA
<213> Rattus norvegicus
<308> D90258
<400> 2330

cgttctgtg  cctgccggg  cagcaccat  agctccatt  gcactgggt  tgacctgtc  60
gcctctaca  tctctcctg  tggaagagt  ttccaagtt  aatatgcta  gaaggctgt  120
gaaaacagt  gtacagcta  tgggatcag  tgtaaagat  gtgttgtgt  tggggtaga  180
aaattagtc  tttctaaac  ttatgaaga  ggctccaat  aacgtcttt  caatgttga  240
cgacatgtt  gaatggcag  ggcaggttt  ttggcagat  ctcgttcct  ggcagacat  300
gcaagagaa  aagcgtcca  ctttaggtc  aactttggc  ataacattc  tctaaaaca  360
cttgcagac  gagtggcca  gtatgtaca  gcgtataca  tctacagtg  tgttagacc  420
tttggctgc  gtttcatgt  ggggtctta  agtgtgaat  atggtgcac  gctctatat  480
atcgatcca  caggtgttt  atatggtta  tggggctgt  ccattggca  agccaggca  540
gctgcaaag  cagaaatag  aaagcttca  atgaaggaa  tgacctgcc  tgatgtagt  600
aaagaagtt  caaaaataa  ttacatagt  catgatgaa  ttaaggata  agcttttga  660
ctagagctc  gctgggttg  tgaattaac  aaaggaaga  atgaaattg  tcccaaaga  720
gtaagagag  aagcagaga  atatgccaa  gaatctttg  aggaagaag  tgaatcaga  780
gacgacaat  tgtaacatt  caccatcct  tggtgtcca  ttctgtgac  gttgcatat  840
gctagcacc  tggattata  atacccact  accaatttt  attaaattt  gtcttat  897



<210> 2331
<211> 254
<212> PRT
<213> Rattus norvegicus
<308> BAA14302
<400> 2331

Ser Ser Ile Gly Thr Gly Tyr Asp Leu Ser Ala Ser Thr Phe Ser Pro 
  1               5                  10                  15
Asp Gly Arg Val Phe Gln Val Glu Tyr Ala Met Lys Ala Val Glu Asn 
             20                  25                  30
Ser Ser Thr Ala Ile Gly Ile Arg Cys Lys Asp Gly Val Val Phe Gly 
         35                  40                  45
Val Glu Lys Leu Val Leu Ser Lys Leu Tyr Glu Glu Gly Ser Asn Lys 
     50                  55                  60
Arg Leu Phe Asn Val Asp Arg His Val Gly Met Ala Val Ala Gly Leu 
 65                  70                  75                  80
Leu Ala Asp Ala Arg Ser Leu Ala Asp Ile Ala Arg Glu Glu Ala Ser 
                 85                  90                  95
Asn Phe Arg Ser Asn Phe Gly Tyr Asn Ile Pro Leu Lys His Leu Ala 
             100                105                110
Asp Arg Val Ala Met Tyr Val His Ala Tyr Thr Leu Tyr Ser Ala Val 
         115                120                125
Arg Pro Phe Gly Cys Ser Phe Met Leu Gly Ser Tyr Ser Val Asn Asp 
     130                135                140
Gly Ala Gln Leu Tyr Met Ile Asp Pro Ser Gly Val Ser Tyr Gly Tyr 
 145                150                155                160
Trp Gly Cys Ala Ile Gly Lys Ala Arg Gln Ala Ala Lys Thr Glu Ile 
                 165                170                175
Glu Lys Leu Gln Met Lys Glu Met Thr Cys Arg Asp Val Val Lys Glu 
             180                185                190
Val Ala Lys Ile Ile Tyr Ile Val His Asp Glu Val Lys Asp Lys Ala 
         195                200                205
Phe Glu Leu Glu Leu Ser Trp Val Gly Glu Leu Thr Lys Gly Arg His 
     210                215                220
Glu Ile Val Pro Lys Asp Val Arg Glu Glu Ala Glu Lys Tyr Ala Lys 
 225                230                235                240
Glu Ser Leu Lys Glu Glu Asp Glu Ser Asp Asp Asp Asn Met 
                 245                250



<210> 2332
<211> 838
<212> DNA
<213> Homo sapiens
<308> NM_002788
<400> 2332

gcacgatga  ctcaatcgg  actgggtat  acctgtcag  ctctacatt  tctcctgac  60
gaagagttt  tcaagttga  tatgctatg  aggctgtgg  aaatagtag  acagctatt  120
gaatcagat  caaagatgg  gttgtcttt  gggtagaaa  attagtcct  tctaaactt  180
atgaagaag  ttccaacaa  agacttttt  atgttgatc  gcatgttgg  atggcagta  240
caggtttgt  ggcagatgc  cgttcttta  cagacatag  aagagaaga  gcttccaac  300
tcagatcta  ctttggcta  aacattcca  taaaacatc  tgcagacag  gtggccatg  360
atgtgcatg  atatacact  tacagtgct  ttagacctt  tggctgcag  ttcatgtta  420
ggtcttaca  tgtgaatga  ggtgcgcaa  tctacatga  tgacccatc  ggtgtttca  480
acggttatt  gggctgtgc  atcggcaaa  ccaggcaag  tgcaaagac  gaaatagag  540
agcttcaga  gaaagaaat  acctgccgt  atatcgtta  agaagttgc  aaaataatt  600
acatagtac  tgacgaagt  aaggataaa  cttttgaac  agaactcag  tgggttggt  660
aattaacta  tggaagaca  gaaattgtt  caaaagata  aagagaaga  gcagagaaa  720
atgctaagg  atctctgaa  gaagaagat  aatcagatg  tgataatat  taacattta  780
tccagcatc  attgtattt  aaatttcta  tccagtcca  tgtaactat  tagccctg  838



<210> 2333
<211> 254
<212> PRT
<213> Homo sapiens
<308> P25788
<400> 2333

Ser Ser Ile Gly Thr Gly Tyr Asp Leu Ser Ala Ser Thr Phe Ser Pro 
  1               5                  10                  15
Asp Gly Arg Val Phe Gln Val Glu Tyr Ala Met Lys Ala Val Glu Asn 
             20                  25                  30
Ser Ser Thr Ala Ile Gly Ile Arg Cys Lys Asp Gly Val Val Phe Gly 
         35                  40                  45
Val Glu Lys Leu Val Leu Ser Lys Leu Tyr Glu Glu Gly Ser Asn Lys 
     50                  55                  60
Arg Leu Phe Asn Val Asp Arg His Val Gly Met Ala Val Ala Gly Leu 
 65                  70                  75                  80
Leu Ala Asp Ala Arg Ser Leu Ala Asp Ile Ala Arg Glu Glu Ala Ser 
                 85                  90                  95
Asn Phe Arg Ser Asn Phe Gly Tyr Asn Ile Pro Leu Lys His Leu Ala 
             100                105                110
Asp Arg Val Ala Met Tyr Val His Ala Tyr Thr Leu Tyr Ser Ala Val 
         115                120                125
Arg Pro Phe Gly Cys Ser Phe Met Leu Gly Ser Tyr Ser Val Asn Asp 
     130                135                140
Gly Ala Gln Leu Tyr Met Ile Asp Pro Ser Gly Val Ser Tyr Gly Tyr 
 145                150                155                160
Trp Gly Cys Ala Ile Gly Lys Ala Arg Gln Ala Ala Lys Thr Glu Ile 
                 165                170                175
Glu Lys Leu Gln Met Lys Glu Met Thr Cys Arg Asp Ile Val Lys Glu 
             180                185                190
Val Ala Lys Ile Ile Tyr Ile Val His Asp Glu Val Lys Asp Lys Ala 
         195                200                205
Phe Glu Leu Glu Leu Ser Trp Val Gly Glu Leu Thr Asn Gly Arg His 
     210                215                220
Glu Ile Val Pro Lys Asp Ile Arg Glu Glu Ala Glu Lys Tyr Ala Lys 
 225                230                235                240
Glu Ser Leu Lys Glu Glu Asp Glu Ser Asp Asp Asp Asn Met 
                 245                250



<210> 2334
<211> 2749
<212> DNA
<213> Rattus norvegicus
<308> D90401
<400> 2334

tcccggtcc  gctgcgtgt  ccgggcgtt  atgcgctcg  tttctgcct  ccagaaggg  60
aactgccct  tagggagac  ttccctgcc  ggggtctcc  tatgtcagg  accaggtta  120
cctgacagc  ggaagatgg  cattaacac  gtagccgtc  tcagtgttc  cttcttcca  180
accacggca  tgtgcaaga  tgatgtgat  acagtccag  ccccagcgt  tgcagagtc  240
gtcacagag  gagatgtca  gtgggagaa  gctgttgga  atgcagttg  agaagatga  300
gtggtgtgt  agattgaga  agacaagac  tctgtgcag  ttccatcac  agcaaatgg  360
atcattgaa  ctcttttgg  acccgatgg  ggcaaagtt  aaggaggaa  tcctctatt  420
acactcagg  aaaccggtg  tgctcctgc  aaggccaaa  cagctgaag  ccctgctac  480
gcccacaaa  cagcgcctg  agcaccggc  gcccctcct  ctcctgtag  accagtgcc  540
actcagatg  cacctgtgc  ctcaccctc  caacctcct  ctagcaaac  agtgtctgc  600
ataaaaccc  ctgctgccc  tccactggc  gaggcggga  ctgctaaag  cctgcgctc  660
gaacatcgg  aaaagatga  caggatgcg  cagcgcatc  cccagcgtc  gaaggaagc  720
cagaacacc  gcgcaatgc  gacgacgtt  aatgaggtt  acatgagta  catacaaga  780
atgagagct  ggcacaaag  tgctttcct  aaaaaacat  acctgaaat  aggcctcat  840
tcggcattt  tgaaggcct  agcattcgc  ttgcaggag  agcctgtag  aaacgcagt  900
attgatgac  caaccaagg  ggtggtgta  agagattat  ttgacatca  tgtcgcagt  960
gctacccca  ggggtctcg  ggttcctgt  atcaggaat  tggaaacta  gaattatgc  1020
gatattgaa  ggaccatta  tgaactagg  gagaaggcc  ggaagaatg  acttgccat  1080
gaagacatg  atgggggca  cttcaccat  agcaatgga  gagttttcg  ctcactttt  1140
ggaacaccc  ttatcaacc  gcctcagtc  gccattctg  gcatgcatg  catcttcga  1200
aggcctgtg  ctgtggggg  caaggtgga  gtccgacct  tgatgtatg  agccctgac  1260
tacgaccac  ggctgattg  tggcagaga  gctgtgact  tcctccgaa  aatcaaggc  1320
gcagtagaa  atccagcag  cctcctcct  gacctttag  aggaagcca  acatgccta  1380
ctactgatc  tgcaggaat  aaaaaccag  cttctagcc  gtgcaacct  ctcagtcca  1440
gttaactga  ggcaggcag  cactaccat  ggcctcgag  aaggactcc  gggcactac  1500
taaccaggc  tagggcatc  gtcctttca  gggtctttt  atgctcctt  tggctcttc  1560
tctctcctg  gctcttcct  ctgctctct  ggcctgaca  agagagaga  agagagaga  1620
agagagaga  agagagaga  agagagagc  tgtgaatgc  catcaatag  cctgccttt  1680
ttccagtcc  ctacaaaga  acctttgct  ctctccagt  acagtatgc  atagggaat  1740
ccaccaggg  ccatgtgat  gagtttctt  tctttggaa  gtgttctcc  aaagatgcc  1800
agggggaag  tttgctccg  ggctcaaag  agcctgtgt  gcagctgtt  ttggtctca  1860
ttgatgccc  ctgtgtggg  attgaagat  ggcaaagcg  ggctacctc  tcctaacct  1920
tcagcggct  caaggtgcc  ctctacctc  gacaggagc  caggctgga  gatttaggg  1980
taggcacaa  tgtgctggg  ccctgaggc  acctgtgta  tgcacagat  ggagtgaaa  2040
ttggcttgc  ctttacagg  ctccattgt  tgctggcac  gggaagatt  atgttgtca  2100
aactacgta  aactgttgt  catcatacc  accctttcc  gcttctagg  atcattcta  2160
gacggtgtt  tcacgtaaa  cagatttta  catatcatg  cagtgggac  cctggtgaa  2220
ggactgttc  caccagatc  ggctgatga  accttttaa  ttcaaggtg  tacgagcat  2280
tgctggggt  gggcctgtt  tctcccaac  tgggatgtg  cctgtgggg  gcaaggcct  2340
ggttcctct  gtgttggac  cagataagg  gaggatgga  tgtggcggg  accagcctc  2400
ggagttagg  gagtgaaga  ataatgacg  catcgctac  ctcaccctt  aggggatag  2460
tggtagtta  aatattttt  aagcatggt  aaatgtaat  aactggtta  gaaagctcc  2520
agcccttgt  tccttcact  agcctgaga  tgctgacag  tgacatggg  ccattagtg  2580
tgaatgccc  tttttcttg  aatccaaga  ttcctgggg  aagagggga  gaggtcagt  2640
ttgagtgcc  gcaacatct  ctacgtata  ctataccat  cagaacttg  aatgaaaat  2700
tttaaagag  ctgattttg  atgaaaatt  aagggcaaa  gttctcaaa  2749



<210> 2335
<211> 442
<212> PRT
<213> Rattus norvegicus
<308> Q01205
<400> 2335

Met Arg Ser Leu Ser Ala Phe Gln Lys Gly Asn Cys Pro Leu Gly Arg 
  1               5                  10                  15
Arg Ser Leu Pro Gly Val Ser Leu Cys Gln Gly Pro Gly Tyr Pro Asp 
             20                  25                  30
Ser Arg Lys Met Val Ile Asn Thr Val Ala Val Phe Ser Val Arg Phe 
         35                  40                  45
Phe Gln Thr Thr Ala Val Cys Lys Asn Asp Val Ile Thr Val Gln Thr 
     50                  55                  60
Pro Ala Phe Ala Glu Ser Val Thr Glu Gly Asp Val Arg Trp Glu Lys 
 65                  70                  75                  80
Ala Val Gly Asp Ala Val Ala Glu Asp Glu Val Val Cys Glu Ile Glu 
                 85                  90                  95
Thr Asp Lys Thr Ser Val Gln Val Pro Ser Pro Ala Asn Gly Ile Ile 
             100                105                110
Glu Ala Leu Leu Val Pro Asp Gly Gly Lys Val Glu Gly Gly Thr Pro 
         115                120                125
Leu Phe Thr Leu Arg Lys Thr Gly Ala Ala Pro Ala Lys Ala Lys Pro 
     130                135                140
Ala Glu Ala Pro Ala Thr Ala His Lys Ala Ala Pro Glu Ala Pro Ala 
 145                150                155                160
Ala Pro Pro Pro Pro Val Ala Pro Val Pro Thr Gln Met Pro Pro Val 
                 165                170                175
Pro Ser Pro Ser Gln Pro Pro Ser Ser Lys Pro Val Ser Ala Ile Lys 
             180                185                190
Pro Thr Ala Ala Pro Pro Leu Ala Glu Ala Gly Ala Ala Lys Gly Leu 
         195                200                205
Arg Ser Glu His Arg Glu Lys Met Asn Arg Met Arg Gln Arg Ile Ala 
     210                215                220
Gln Arg Leu Lys Glu Ala Gln Asn Thr Cys Ala Met Leu Thr Thr Phe 
 225                230                235                240
Asn Glu Val Asp Met Ser Asn Ile Gln Glu Met Arg Ala Arg His Lys 
                 245                250                255
Asp Ala Phe Leu Lys Lys His Asn Leu Lys Leu Gly Leu Met Ser Ala 
             260                265                270
Phe Val Lys Ala Ser Ala Phe Ala Leu Gln Glu Gln Pro Val Val Asn 
         275                280                285
Ala Val Ile Asp Asp Ala Thr Lys Glu Val Val Tyr Arg Asp Tyr Ile 
     290                295                300
Asp Ile Ser Val Ala Val Ala Thr Pro Arg Gly Leu Val Val Pro Val 
 305                310                315                320
Ile Arg Asn Val Glu Thr Met Asn Tyr Ala Asp Ile Glu Arg Thr Ile 
                 325                330                335
Asn Glu Leu Gly Glu Lys Ala Arg Lys Asn Glu Leu Ala Ile Glu Asp 
             340                345                350
Met Asp Gly Gly Thr Phe Thr Ile Ser Asn Gly Gly Val Phe Gly Ser 
         355                360                365
Leu Phe Gly Thr Pro Ile Ile Asn Pro Pro Gln Ser Ala Ile Leu Gly 
     370                375                380
Met His Gly Ile Phe Asp Arg Pro Val Ala Val Gly Gly Lys Val Glu 
 385                390                395                400
Val Arg Pro Met Met Tyr Val Ala Leu Thr Tyr Asp His Arg Leu Ile 
                 405                410                415
Asp Gly Arg Glu Ala Val Thr Phe Leu Arg Lys Ile Lys Ala Ala Val 
             420                425                430
Glu Asp Pro Ala Val Leu Leu Leu Asp Leu 
         435                440



<210> 2336
<211> 510
<212> DNA
<213> Homo sapiens
<308> AI184508
<400> 2336

ttttatggg  ataagtgtt  tttatttta  aaagcacca  tgcttacag  caaaactgt  60
atagacatg  cttgggagg  aaaaataca  atatatgaa  tatggcttg  aaatttctg  120
atatcagta  ttaacagcg  ttttaaaac  ctgccatca  accaatctt  agtgtaaga  180
agaaacaaa  ctgcatcac  tcttcaagt  ctaaggatc  atttcactt  atggtaccc  240
caaaatact  gccagctct  tgttctcac  cagaaggtg  ctttcataa  ctgcacctt  300
aaaatatat  gtccaagta  ctggtgaac  tgtgtgagg  attaacctg  aaaatcctc  360
ctggcacag  gggtctaaa  attcttgta  accatttgg  atgtttctg  caacatcac  420
agaataacc  tcttctggc  aaagaaacg  cagctgcag  tcaggatcc  cctccaact  480
cacttccct  ccatcactg  gggccagctc  510



<210> 2337
<211> 1816
<212> PRT
<213> Homo sapiens
<308> P55196
<400> 2337

Met Ser Ala Gly Gly Arg Asp Glu Glu Arg Arg Lys Leu Ala Asp Ile 
  1               5                  10                  15
Ile His His Trp Asn Ala Asn Arg Leu Asp Leu Phe Glu Ile Ser Gln 
             20                  25                  30
Pro Thr Glu Asp Leu Glu Phe His Gly Val Met Arg Phe Tyr Phe Gln 
         35                  40                  45
Asp Lys Ala Ala Gly Asn Phe Ala Thr Lys Cys Ile Arg Val Ser Ser 
     50                  55                  60
Thr Ala Thr Thr Gln Asp Val Ile Glu Thr Leu Ala Glu Lys Phe Arg 
 65                  70                  75                  80
Pro Asp Met Arg Met Leu Ser Ser Pro Lys Tyr Ser Leu Tyr Glu Val 
                 85                  90                  95
His Val Ser Gly Glu Arg Arg Leu Asp Ile Asp Glu Lys Pro Leu Val 
             100                105                110
Val Gln Leu Asn Trp Asn Lys Asp Asp Arg Glu Gly Arg Phe Val Leu 
         115                120                125
Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys Ala Gln Ser Asn Gly Pro 
     130                135                140
Glu Lys Gln Glu Lys Glu Gly Val Ile Gln Asn Phe Lys Arg Thr Leu 
 145                150                155                160
Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys Arg Glu Lys Glu Ala Leu 
                 165                170                175
Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro Phe Gln Gly Glu Asp Val 
             180                185                190
Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr Lys Asp Met Pro Glu Thr 
         195                200                205
Ser Phe Thr Arg Thr Ile Ser Asn Pro Glu Val Val Met Lys Arg Arg 
     210                215                220
Arg Gln Gln Lys Leu Glu Lys Arg Met Gln Glu Phe Arg Ser Ser Asp 
 225                230                235                240
Gly Arg Pro Asp Ser Gly Gly Thr Leu Arg Ile Tyr Ala Asp Ser Leu 
                 245                250                255
Lys Pro Asn Ile Pro Tyr Lys Thr Ile Leu Leu Ser Thr Thr Asp Pro 
             260                265                270
Ala Asp Phe Ala Val Ala Glu Ala Leu Glu Lys Tyr Gly Leu Glu Lys 
         275                280                285
Glu Asn Pro Lys Asp Tyr Cys Ile Ala Arg Val Met Leu Pro Pro Gly 
     290                295                300
Ala Gln His Ser Asp Glu Lys Gly Ala Lys Glu Ile Ile Leu Asp Asp 
 305                310                315                320
Asp Glu Cys Pro Leu Gln Ile Phe Arg Glu Trp Pro Ser Asp Lys Gly 
                 325                330                335
Ile Leu Val Phe Gln Leu Lys Arg Arg Pro Pro Asp His Ile Pro Lys 
             340                345                350
Lys Thr Lys Lys His Leu Glu Gly Lys Thr Pro Lys Gly Lys Glu Arg 
         355                360                365
Ala Asp Gly Ser Gly Tyr Gly Ser Thr Leu Pro Pro Glu Lys Leu Pro 
     370                375                380
Tyr Leu Val Glu Leu Ser Pro Asp Gly Ser Asp Ser Arg Asp Lys Pro 
 385                390                395                400
Lys Leu Tyr Arg Leu Gln Leu Ser Val Thr Glu Val Gly Thr Glu Lys 
                 405                410                415
Leu Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro Gly Ile Gln Pro His 
             420                425                430
His Cys Asp Leu Thr Asn Met Asp Gly Val Val Thr Val Thr Pro Arg 
         435                440                445
Ser Met Asp Ala Glu Thr Tyr Val Glu Gly Gln Arg Ile Ser Glu Thr 
     450                455                460
Thr Met Leu Gln Ser Gly Met Lys Val Gln Phe Gly Ala Ser His Val 
 465                470                475                480
Phe Lys Phe Val Asp Pro Ser Gln Asp His Ala Leu Ala Lys Arg Ser 
                 485                490                495
Val Asp Gly Gly Leu Met Val Lys Gly Pro Arg His Lys Pro Gly Ile 
             500                505                510
Val Gln Glu Thr Thr Phe Asp Leu Gly Gly Asp Ile His Ser Gly Thr 
         515                520                525
Ala Leu Pro Thr Ser Lys Ser Thr Thr Arg Leu Asp Ser Asp Arg Val 
     530                535                540
Ser Ser Ala Ser Ser Thr Ala Glu Arg Gly Met Val Lys Pro Met Ile 
 545                550                555                560
Arg Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln Glu Ser Arg Thr Gln 
                 565                570                575
Asp Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala Ser Ile Glu Phe Arg 
             580                585                590
Glu Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile Ile Asn Tyr Thr Asn 
         595                600                605
Ser Ser Thr Val His Phe Lys Leu Ser Pro Thr Tyr Val Leu Tyr Met 
     610                615                620
Ala Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg Pro Asp Ile Ser Pro 
 625                630                635                640
Thr Glu Arg Thr His Lys Val Ile Ala Val Val Asn Lys Met Val Ser 
                 645                650                655
Met Met Glu Gly Val Ile Gln Lys Gln Lys Asn Ile Ala Gly Ala Leu 
             660                665                670
Ala Phe Trp Met Ala Asn Ala Ser Glu Leu Leu Asn Phe Ile Lys Gln 
         675                680                685
Asp Arg Asp Leu Ser Arg Ile Thr Leu Asp Ala Gln Asp Val Leu Ala 
     690                695                700
His Leu Val Gln Met Ala Phe Lys Tyr Leu Val His Cys Leu Gln Ser 
 705                710                715                720
Glu Leu Asn Asn Tyr Met Pro Ala Phe Leu Asp Asp Pro Glu Glu Asn 
                 725                730                735
Ser Leu Gln Arg Pro Lys Ile Asp Asp Val Leu His Thr Leu Thr Gly 
             740                745                750
Ala Met Ser Leu Leu Arg Arg Cys Arg Val Asn Ala Ala Leu Thr Ile 
         755                760                765
Gln Leu Phe Ser Gln Leu Phe His Phe Ile Asn Met Trp Leu Phe Asn 
     770                775                780
Arg Leu Val Thr Asp Pro Asp Ser Gly Leu Cys Ser His Tyr Trp Gly 
 785                790                795                800
Ala Ile Ile Arg Gln Gln Leu Gly His Ile Glu Ala Trp Ala Glu Lys 
                 805                810                815
Gln Gly Leu Glu Leu Ala Ala Asp Cys His Leu Ser Arg Ile Val Gln 
             820                825                830
Ala Thr Thr Leu Leu Thr Met Asp Lys Tyr Ala Pro Asp Asp Ile Pro 
         835                840                845
Asn Ile Asn Ser Thr Cys Phe Lys Leu Asn Ser Leu Gln Leu Gln Ala 
     850                855                860
Leu Leu Gln Asn Tyr His Cys Ala Pro Asp Glu Pro Phe Ile Pro Thr 
 865                870                875                880
Asp Leu Ile Glu Asn Val Val Thr Val Ala Glu Asn Thr Ala Asp Glu 
                 885                890                895
Leu Ala Arg Ser Asp Gly Arg Glu Val Gln Leu Glu Glu Asp Pro Asp 
             900                905                910
Leu Gln Leu Pro Phe Leu Leu Pro Glu Asp Gly Tyr Ser Cys Asp Val 
         915                920                925
Val Arg Asn Ile Pro Asn Gly Leu Gln Glu Phe Leu Asp Pro Leu Cys 
     930                935                940
Gln Arg Gly Phe Cys Arg Leu Ile Pro His Thr Arg Ser Pro Gly Thr 
 945                950                955                960
Trp Thr Ile Tyr Phe Glu Gly Ala Asp Tyr Glu Ser His Leu Leu Arg 
                 965                970                975
Glu Asn Thr Glu Leu Ala Gln Pro Leu Arg Lys Glu Pro Glu Ile Ile 
             980                985                990
Thr Val Thr Leu Lys Lys Gln Asn Gly Met Gly Leu Ser Ile Val Ala 
         995                1000                1005
Ala Lys Gly Ala Gly Gln Asp Lys Leu Gly Ile Tyr Val Lys Ser Val 
     1010                1015                1020
Val Lys Gly Gly Ala Ala Asp Asp Gly Arg Leu Ala Ala Gly Asp Gln 
 1025                1030                1035                1040
Leu Leu Ser Val Asp Gly Arg Ser Leu Val Gly Leu Ser Gln Glu Arg 
                 1045                1050                1055
Ala Ala Glu Leu Met Thr Arg Thr Ser Ser Val Val Thr Leu Glu Val 
             1060                1065                1070
Ala Lys Gln Gly Ala Ile Tyr His Gly Leu Ala Thr Leu Leu Asn Gln 
         1075                1080                1085
Pro Ser Pro Met Met Gln Arg Ile Ser Asp Arg Arg Gly Ser Gly Lys 
     1090                1095                1100
Pro Arg Pro Lys Ser Glu Gly Phe Glu Leu Tyr Asn Asn Ser Thr Gln 
 1105                1110                1115                1120
Asn Gly Ser Pro Glu Ser Pro Gln Leu Pro Trp Ala Glu Tyr Ser Glu 
                 1125                1130                1135
Pro Lys Lys Leu Pro Gly Asp Asp Arg Leu Met Lys Asn Arg Ala Asp 
             1140                1145                1150
His Arg Ser Ser Pro Asn Val Ala Asn Gln Pro Pro Ser Pro Gly Gly 
         1155                1160                1165
Lys Ser Ala Tyr Ala Ser Gly Thr Thr Ala Lys Ile Thr Ser Val Ser 
     1170                1175                1180
Thr Gly Asn Leu Cys Thr Glu Glu Gln Thr Pro Pro Pro Arg Pro Glu 
 1185                1190                1195                1200
Ala Tyr Pro Ile Pro Thr Gln Thr Tyr Thr Arg Glu Tyr Phe Thr Phe 
                 1205                1210                1215
Pro Ala Ser Lys Ser Gln Asp Arg Met Ala Pro Pro Gln Asn Gln Trp 
             1220                1225                1230
Pro Asn Tyr Glu Glu Lys Pro His Met His Thr Asp Ser Asn His Ser 
         1235                1240                1245
Ser Ile Ala Ile Gln Arg Val Thr Arg Ser Gln Glu Glu Leu Arg Glu 
     1250                1255                1260
Asp Lys Ala Tyr Gln Leu Glu Arg His Arg Ile Glu Ala Ala Met Asp 
 1265                1270                1275                1280
Arg Lys Ser Asp Ser Asp Met Trp Ile Asn Gln Ser Ser Ser Leu Asp 
                 1285                1290                1295
Ser Ser Thr Ser Ser Gln Glu His Leu Asn His Ser Ser Lys Ser Val 
             1300                1305                1310
Thr Pro Ala Ser Thr Leu Thr Lys Ser Gly Pro Gly Arg Trp Lys Thr 
         1315                1320                1325
Pro Ala Ala Ile Pro Ala Thr Pro Val Ala Val Ser Gln Pro Ile Arg 
     1330                1335                1340
Thr Asp Leu Pro Pro Pro Pro Pro Pro Pro Pro Val His Tyr Ala Gly 
 1345                1350                1355                1360
Asp Phe Asp Gly Met Ser Met Asp Leu Pro Leu Pro Pro Pro Pro Ser 
                 1365                1370                1375
Ala Asn Gln Ile Gly Leu Pro Ser Ala Gln Val Ala Ala Ala Glu Arg 
             1380                1385                1390
Arg Lys Arg Glu Glu His Gln Arg Trp Tyr Glu Lys Glu Lys Ala Arg 
         1395                1400                1405
Leu Glu Glu Glu Arg Glu Arg Lys Arg Arg Glu Gln Glu Arg Lys Leu 
     1410                1415                1420
Gly Gln Met Arg Thr Gln Ser Leu Asn Pro Ala Pro Phe Ser Pro Leu 
 1425                1430                1435                1440
Thr Ala Gln Gln Met Lys Pro Glu Lys Pro Ser Thr Leu Gln Arg Pro 
                 1445                1450                1455
Gln Glu Thr Val Ile Arg Glu Leu Gln Pro Gln Gln Gln Pro Arg Thr 
             1460                1465                1470
Ile Glu Arg Arg Asp Leu Gln Tyr Ile Thr Val Ser Lys Glu Glu Leu 
         1475                1480                1485
Ser Ser Gly Asp Ser Leu Ser Pro Asp Pro Trp Lys Arg Asp Ala Lys 
     1490                1495                1500
Glu Lys Leu Glu Lys Gln Gln Gln Met His Ile Val Asp Met Leu Ser 
 1505                1510                1515                1520
Lys Glu Ile Gln Glu Leu Gln Ser Lys Pro Asp Arg Ser Ala Glu Glu 
                 1525                1530                1535
Ser Asp Arg Leu Arg Lys Leu Met Leu Glu Trp Gln Phe Gln Lys Arg 
             1540                1545                1550
Leu Gln Glu Ser Lys Gln Lys Asp Glu Asp Asp Glu Glu Glu Glu Asp 
         1555                1560                1565
Asp Asp Val Asp Thr Met Leu Ile Met Gln Arg Leu Glu Ala Glu Arg 
     1570                1575                1580
Arg Ala Arg Leu Gln Asp Glu Glu Arg Arg Arg Gln Gln Gln Leu Glu 
 1585                1590                1595                1600
Glu Met Arg Lys Arg Glu Ala Glu Asp Arg Ala Arg Gln Glu Glu Glu 
                 1605                1610                1615
Arg Arg Arg Gln Glu Glu Glu Arg Thr Lys Arg Asp Ala Glu Glu Lys 
             1620                1625                1630
Arg Arg Gln Glu Glu Gly Tyr Tyr Ser Arg Leu Glu Ala Glu Arg Arg 
         1635                1640                1645
Arg Gln His Asp Glu Ala Ala Arg Arg Leu Leu Glu Pro Glu Ala Pro 
     1650                1655                1660
Gly Leu Cys Arg Pro Pro Leu Pro Arg Asp Tyr Glu Pro Pro Ser Pro 
 1665                1670                1675                1680
Ser Pro Ala Pro Gly Ala Pro Pro Pro Pro Pro Gln Arg Asn Ala Ser 
                 1685                1690                1695
Tyr Leu Lys Thr Gln Val Leu Ser Pro Asp Ser Leu Phe Thr Ala Lys 
             1700                1705                1710
Phe Val Ala Tyr Asn Glu Glu Glu Glu Glu Glu Asp Cys Ser Leu Ala 
         1715                1720                1725
Gly Gln Asp Lys Tyr Ser Ser Thr Arg Lys Ser His Gly Asp Leu Leu 
     1730                1735                1740
Pro Ala Pro Leu Lys Pro Arg Pro Pro Pro Cys Gln Pro Arg Pro Ala 
 1745                1750                1755                1760
Ser Asp Gly Val Phe Leu Ser Asn Ser Phe Gln Pro Pro Ser Ala Lys 
                 1765                1770                1775
Ala Asn Ser Thr Ala His Lys Lys Gly Gln Pro Leu Pro Pro Pro Lys 
             1780                1785                1790
Lys Ser Ser Ser Tyr His Pro Ser His Cys Lys Gly Arg Gly Lys Arg 
         1795                1800                1805
Val Thr Asn Gln Leu Ser Leu Ser 
     1810                1815



<210> 2338
<211> 2749
<212> DNA
<213> Rattus norvegicus
<308> D90401
<400> 2338

tcccggtcc  gctgcgtgt  ccgggcgtt  atgcgctcg  tttctgcct  ccagaaggg  60
aactgccct  tagggagac  ttccctgcc  ggggtctcc  tatgtcagg  accaggtta  120
cctgacagc  ggaagatgg  cattaacac  gtagccgtc  tcagtgttc  cttcttcca  180
accacggca  tgtgcaaga  tgatgtgat  acagtccag  ccccagcgt  tgcagagtc  240
gtcacagag  gagatgtca  gtgggagaa  gctgttgga  atgcagttg  agaagatga  300
gtggtgtgt  agattgaga  agacaagac  tctgtgcag  ttccatcac  agcaaatgg  360
atcattgaa  ctcttttgg  acccgatgg  ggcaaagtt  aaggaggaa  tcctctatt  420
acactcagg  aaaccggtg  tgctcctgc  aaggccaaa  cagctgaag  ccctgctac  480
gcccacaaa  cagcgcctg  agcaccggc  gcccctcct  ctcctgtag  accagtgcc  540
actcagatg  cacctgtgc  ctcaccctc  caacctcct  ctagcaaac  agtgtctgc  600
ataaaaccc  ctgctgccc  tccactggc  gaggcggga  ctgctaaag  cctgcgctc  660
gaacatcgg  aaaagatga  caggatgcg  cagcgcatc  cccagcgtc  gaaggaagc  720
cagaacacc  gcgcaatgc  gacgacgtt  aatgaggtt  acatgagta  catacaaga  780
atgagagct  ggcacaaag  tgctttcct  aaaaaacat  acctgaaat  aggcctcat  840
tcggcattt  tgaaggcct  agcattcgc  ttgcaggag  agcctgtag  aaacgcagt  900
attgatgac  caaccaagg  ggtggtgta  agagattat  ttgacatca  tgtcgcagt  960
gctacccca  ggggtctcg  ggttcctgt  atcaggaat  tggaaacta  gaattatgc  1020
gatattgaa  ggaccatta  tgaactagg  gagaaggcc  ggaagaatg  acttgccat  1080
gaagacatg  atgggggca  cttcaccat  agcaatgga  gagttttcg  ctcactttt  1140
ggaacaccc  ttatcaacc  gcctcagtc  gccattctg  gcatgcatg  catcttcga  1200
aggcctgtg  ctgtggggg  caaggtgga  gtccgacct  tgatgtatg  agccctgac  1260
tacgaccac  ggctgattg  tggcagaga  gctgtgact  tcctccgaa  aatcaaggc  1320
gcagtagaa  atccagcag  cctcctcct  gacctttag  aggaagcca  acatgccta  1380
ctactgatc  tgcaggaat  aaaaaccag  cttctagcc  gtgcaacct  ctcagtcca  1440
gttaactga  ggcaggcag  cactaccat  ggcctcgag  aaggactcc  gggcactac  1500
taaccaggc  tagggcatc  gtcctttca  gggtctttt  atgctcctt  tggctcttc  1560
tctctcctg  gctcttcct  ctgctctct  ggcctgaca  agagagaga  agagagaga  1620
agagagaga  agagagaga  agagagagc  tgtgaatgc  catcaatag  cctgccttt  1680
ttccagtcc  ctacaaaga  acctttgct  ctctccagt  acagtatgc  atagggaat  1740
ccaccaggg  ccatgtgat  gagtttctt  tctttggaa  gtgttctcc  aaagatgcc  1800
agggggaag  tttgctccg  ggctcaaag  agcctgtgt  gcagctgtt  ttggtctca  1860
ttgatgccc  ctgtgtggg  attgaagat  ggcaaagcg  ggctacctc  tcctaacct  1920
tcagcggct  caaggtgcc  ctctacctc  gacaggagc  caggctgga  gatttaggg  1980
taggcacaa  tgtgctggg  ccctgaggc  acctgtgta  tgcacagat  ggagtgaaa  2040
ttggcttgc  ctttacagg  ctccattgt  tgctggcac  gggaagatt  atgttgtca  2100
aactacgta  aactgttgt  catcatacc  accctttcc  gcttctagg  atcattcta  2160
gacggtgtt  tcacgtaaa  cagatttta  catatcatg  cagtgggac  cctggtgaa  2220
ggactgttc  caccagatc  ggctgatga  accttttaa  ttcaaggtg  tacgagcat  2280
tgctggggt  gggcctgtt  tctcccaac  tgggatgtg  cctgtgggg  gcaaggcct  2340
ggttcctct  gtgttggac  cagataagg  gaggatgga  tgtggcggg  accagcctc  2400
ggagttagg  gagtgaaga  ataatgacg  catcgctac  ctcaccctt  aggggatag  2460
tggtagtta  aatattttt  aagcatggt  aaatgtaat  aactggtta  gaaagctcc  2520
agcccttgt  tccttcact  agcctgaga  tgctgacag  tgacatggg  ccattagtg  2580
tgaatgccc  tttttcttg  aatccaaga  ttcctgggg  aagagggga  gaggtcagt  2640
ttgagtgcc  gcaacatct  ctacgtata  ctataccat  cagaacttg  aatgaaaat  2700
tttaaagag  ctgattttg  atgaaaatt  aagggcaaa  gttctcaaa  2749



<210> 2339
<211> 442
<212> PRT
<213> Rattus norvegicus
<308> Q01205
<400> 2339

Met Arg Ser Leu Ser Ala Phe Gln Lys Gly Asn Cys Pro Leu Gly Arg 
  1               5                  10                  15
Arg Ser Leu Pro Gly Val Ser Leu Cys Gln Gly Pro Gly Tyr Pro Asp 
             20                  25                  30
Ser Arg Lys Met Val Ile Asn Thr Val Ala Val Phe Ser Val Arg Phe 
         35                  40                  45
Phe Gln Thr Thr Ala Val Cys Lys Asn Asp Val Ile Thr Val Gln Thr 
     50                  55                  60
Pro Ala Phe Ala Glu Ser Val Thr Glu Gly Asp Val Arg Trp Glu Lys 
 65                  70                  75                  80
Ala Val Gly Asp Ala Val Ala Glu Asp Glu Val Val Cys Glu Ile Glu 
                 85                  90                  95
Thr Asp Lys Thr Ser Val Gln Val Pro Ser Pro Ala Asn Gly Ile Ile 
             100                105                110
Glu Ala Leu Leu Val Pro Asp Gly Gly Lys Val Glu Gly Gly Thr Pro 
         115                120                125
Leu Phe Thr Leu Arg Lys Thr Gly Ala Ala Pro Ala Lys Ala Lys Pro 
     130                135                140
Ala Glu Ala Pro Ala Thr Ala His Lys Ala Ala Pro Glu Ala Pro Ala 
 145                150                155                160
Ala Pro Pro Pro Pro Val Ala Pro Val Pro Thr Gln Met Pro Pro Val 
                 165                170                175
Pro Ser Pro Ser Gln Pro Pro Ser Ser Lys Pro Val Ser Ala Ile Lys 
             180                185                190
Pro Thr Ala Ala Pro Pro Leu Ala Glu Ala Gly Ala Ala Lys Gly Leu 
         195                200                205
Arg Ser Glu His Arg Glu Lys Met Asn Arg Met Arg Gln Arg Ile Ala 
     210                215                220
Gln Arg Leu Lys Glu Ala Gln Asn Thr Cys Ala Met Leu Thr Thr Phe 
 225                230                235                240
Asn Glu Val Asp Met Ser Asn Ile Gln Glu Met Arg Ala Arg His Lys 
                 245                250                255
Asp Ala Phe Leu Lys Lys His Asn Leu Lys Leu Gly Leu Met Ser Ala 
             260                265                270
Phe Val Lys Ala Ser Ala Phe Ala Leu Gln Glu Gln Pro Val Val Asn 
         275                280                285
Ala Val Ile Asp Asp Ala Thr Lys Glu Val Val Tyr Arg Asp Tyr Ile 
     290                295                300
Asp Ile Ser Val Ala Val Ala Thr Pro Arg Gly Leu Val Val Pro Val 
 305                310                315                320
Ile Arg Asn Val Glu Thr Met Asn Tyr Ala Asp Ile Glu Arg Thr Ile 
                 325                330                335
Asn Glu Leu Gly Glu Lys Ala Arg Lys Asn Glu Leu Ala Ile Glu Asp 
             340                345                350
Met Asp Gly Gly Thr Phe Thr Ile Ser Asn Gly Gly Val Phe Gly Ser 
         355                360                365
Leu Phe Gly Thr Pro Ile Ile Asn Pro Pro Gln Ser Ala Ile Leu Gly 
     370                375                380
Met His Gly Ile Phe Asp Arg Pro Val Ala Val Gly Gly Lys Val Glu 
 385                390                395                400
Val Arg Pro Met Met Tyr Val Ala Leu Thr Tyr Asp His Arg Leu Ile 
                 405                410                415
Asp Gly Arg Glu Ala Val Thr Phe Leu Arg Lys Ile Lys Ala Ala Val 
             420                425                430
Glu Asp Pro Ala Val Leu Leu Leu Asp Leu 
         435                440



<210> 2340
<211> 510
<212> DNA
<213> Homo sapiens
<308> AI184508
<400> 2340

ttttatggg  ataagtgtt  tttatttta  aaagcacca  tgcttacag  caaaactgt  60
atagacatg  cttgggagg  aaaaataca  atatatgaa  tatggcttg  aaatttctg  120
atatcagta  ttaacagcg  ttttaaaac  ctgccatca  accaatctt  agtgtaaga  180
agaaacaaa  ctgcatcac  tcttcaagt  ctaaggatc  atttcactt  atggtaccc  240
caaaatact  gccagctct  tgttctcac  cagaaggtg  ctttcataa  ctgcacctt  300
aaaatatat  gtccaagta  ctggtgaac  tgtgtgagg  attaacctg  aaaatcctc  360
ctggcacag  gggtctaaa  attcttgta  accatttgg  atgtttctg  caacatcac  420
agaataacc  tcttctggc  aaagaaacg  cagctgcag  tcaggatcc  cctccaact  480
cacttccct  ccatcactg  gggccagctc  510



<210> 2341
<211> 1816
<212> PRT
<213> Homo sapiens
<308> P55196
<400> 2341

Met Ser Ala Gly Gly Arg Asp Glu Glu Arg Arg Lys Leu Ala Asp Ile 
  1               5                  10                  15
Ile His His Trp Asn Ala Asn Arg Leu Asp Leu Phe Glu Ile Ser Gln 
             20                  25                  30
Pro Thr Glu Asp Leu Glu Phe His Gly Val Met Arg Phe Tyr Phe Gln 
         35                  40                  45
Asp Lys Ala Ala Gly Asn Phe Ala Thr Lys Cys Ile Arg Val Ser Ser 
     50                  55                  60
Thr Ala Thr Thr Gln Asp Val Ile Glu Thr Leu Ala Glu Lys Phe Arg 
 65                  70                  75                  80
Pro Asp Met Arg Met Leu Ser Ser Pro Lys Tyr Ser Leu Tyr Glu Val 
                 85                  90                  95
His Val Ser Gly Glu Arg Arg Leu Asp Ile Asp Glu Lys Pro Leu Val 
             100                105                110
Val Gln Leu Asn Trp Asn Lys Asp Asp Arg Glu Gly Arg Phe Val Leu 
         115                120                125
Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys Ala Gln Ser Asn Gly Pro 
     130                135                140
Glu Lys Gln Glu Lys Glu Gly Val Ile Gln Asn Phe Lys Arg Thr Leu 
 145                150                155                160
Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys Arg Glu Lys Glu Ala Leu 
                 165                170                175
Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro Phe Gln Gly Glu Asp Val 
             180                185                190
Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr Lys Asp Met Pro Glu Thr 
         195                200                205
Ser Phe Thr Arg Thr Ile Ser Asn Pro Glu Val Val Met Lys Arg Arg 
     210                215                220
Arg Gln Gln Lys Leu Glu Lys Arg Met Gln Glu Phe Arg Ser Ser Asp 
 225                230                235                240
Gly Arg Pro Asp Ser Gly Gly Thr Leu Arg Ile Tyr Ala Asp Ser Leu 
                 245                250                255
Lys Pro Asn Ile Pro Tyr Lys Thr Ile Leu Leu Ser Thr Thr Asp Pro 
             260                265                270
Ala Asp Phe Ala Val Ala Glu Ala Leu Glu Lys Tyr Gly Leu Glu Lys 
         275                280                285
Glu Asn Pro Lys Asp Tyr Cys Ile Ala Arg Val Met Leu Pro Pro Gly 
     290                295                300
Ala Gln His Ser Asp Glu Lys Gly Ala Lys Glu Ile Ile Leu Asp Asp 
 305                310                315                320
Asp Glu Cys Pro Leu Gln Ile Phe Arg Glu Trp Pro Ser Asp Lys Gly 
                 325                330                335
Ile Leu Val Phe Gln Leu Lys Arg Arg Pro Pro Asp His Ile Pro Lys 
             340                345                350
Lys Thr Lys Lys His Leu Glu Gly Lys Thr Pro Lys Gly Lys Glu Arg 
         355                360                365
Ala Asp Gly Ser Gly Tyr Gly Ser Thr Leu Pro Pro Glu Lys Leu Pro 
     370                375                380
Tyr Leu Val Glu Leu Ser Pro Asp Gly Ser Asp Ser Arg Asp Lys Pro 
 385                390                395                400
Lys Leu Tyr Arg Leu Gln Leu Ser Val Thr Glu Val Gly Thr Glu Lys 
                 405                410                415
Leu Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro Gly Ile Gln Pro His 
             420                425                430
His Cys Asp Leu Thr Asn Met Asp Gly Val Val Thr Val Thr Pro Arg 
         435                440                445
Ser Met Asp Ala Glu Thr Tyr Val Glu Gly Gln Arg Ile Ser Glu Thr 
     450                455                460
Thr Met Leu Gln Ser Gly Met Lys Val Gln Phe Gly Ala Ser His Val 
 465                470                475                480
Phe Lys Phe Val Asp Pro Ser Gln Asp His Ala Leu Ala Lys Arg Ser 
                 485                490                495
Val Asp Gly Gly Leu Met Val Lys Gly Pro Arg His Lys Pro Gly Ile 
             500                505                510
Val Gln Glu Thr Thr Phe Asp Leu Gly Gly Asp Ile His Ser Gly Thr 
         515                520                525
Ala Leu Pro Thr Ser Lys Ser Thr Thr Arg Leu Asp Ser Asp Arg Val 
     530                535                540
Ser Ser Ala Ser Ser Thr Ala Glu Arg Gly Met Val Lys Pro Met Ile 
 545                550                555                560
Arg Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln Glu Ser Arg Thr Gln 
                 565                570                575
Asp Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala Ser Ile Glu Phe Arg 
             580                585                590
Glu Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile Ile Asn Tyr Thr Asn 
         595                600                605
Ser Ser Thr Val His Phe Lys Leu Ser Pro Thr Tyr Val Leu Tyr Met 
     610                615                620
Ala Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg Pro Asp Ile Ser Pro 
 625                630                635                640
Thr Glu Arg Thr His Lys Val Ile Ala Val Val Asn Lys Met Val Ser 
                 645                650                655
Met Met Glu Gly Val Ile Gln Lys Gln Lys Asn Ile Ala Gly Ala Leu 
             660                665                670
Ala Phe Trp Met Ala Asn Ala Ser Glu Leu Leu Asn Phe Ile Lys Gln 
         675                680                685
Asp Arg Asp Leu Ser Arg Ile Thr Leu Asp Ala Gln Asp Val Leu Ala 
     690                695                700
His Leu Val Gln Met Ala Phe Lys Tyr Leu Val His Cys Leu Gln Ser 
 705                710                715                720
Glu Leu Asn Asn Tyr Met Pro Ala Phe Leu Asp Asp Pro Glu Glu Asn 
                 725                730                735
Ser Leu Gln Arg Pro Lys Ile Asp Asp Val Leu His Thr Leu Thr Gly 
             740                745                750
Ala Met Ser Leu Leu Arg Arg Cys Arg Val Asn Ala Ala Leu Thr Ile 
         755                760                765
Gln Leu Phe Ser Gln Leu Phe His Phe Ile Asn Met Trp Leu Phe Asn 
     770                775                780
Arg Leu Val Thr Asp Pro Asp Ser Gly Leu Cys Ser His Tyr Trp Gly 
 785                790                795                800
Ala Ile Ile Arg Gln Gln Leu Gly His Ile Glu Ala Trp Ala Glu Lys 
                 805                810                815
Gln Gly Leu Glu Leu Ala Ala Asp Cys His Leu Ser Arg Ile Val Gln 
             820                825                830
Ala Thr Thr Leu Leu Thr Met Asp Lys Tyr Ala Pro Asp Asp Ile Pro 
         835                840                845
Asn Ile Asn Ser Thr Cys Phe Lys Leu Asn Ser Leu Gln Leu Gln Ala 
     850                855                860
Leu Leu Gln Asn Tyr His Cys Ala Pro Asp Glu Pro Phe Ile Pro Thr 
 865                870                875                880
Asp Leu Ile Glu Asn Val Val Thr Val Ala Glu Asn Thr Ala Asp Glu 
                 885                890                895
Leu Ala Arg Ser Asp Gly Arg Glu Val Gln Leu Glu Glu Asp Pro Asp 
             900                905                910
Leu Gln Leu Pro Phe Leu Leu Pro Glu Asp Gly Tyr Ser Cys Asp Val 
         915                920                925
Val Arg Asn Ile Pro Asn Gly Leu Gln Glu Phe Leu Asp Pro Leu Cys 
     930                935                940
Gln Arg Gly Phe Cys Arg Leu Ile Pro His Thr Arg Ser Pro Gly Thr 
 945                950                955                960
Trp Thr Ile Tyr Phe Glu Gly Ala Asp Tyr Glu Ser His Leu Leu Arg 
                 965                970                975
Glu Asn Thr Glu Leu Ala Gln Pro Leu Arg Lys Glu Pro Glu Ile Ile 
             980                985                990
Thr Val Thr Leu Lys Lys Gln Asn Gly Met Gly Leu Ser Ile Val Ala 
         995                1000                1005
Ala Lys Gly Ala Gly Gln Asp Lys Leu Gly Ile Tyr Val Lys Ser Val 
     1010                1015                1020
Val Lys Gly Gly Ala Ala Asp Asp Gly Arg Leu Ala Ala Gly Asp Gln 
 1025                1030                1035                1040
Leu Leu Ser Val Asp Gly Arg Ser Leu Val Gly Leu Ser Gln Glu Arg 
                 1045                1050                1055
Ala Ala Glu Leu Met Thr Arg Thr Ser Ser Val Val Thr Leu Glu Val 
             1060                1065                1070
Ala Lys Gln Gly Ala Ile Tyr His Gly Leu Ala Thr Leu Leu Asn Gln 
         1075                1080                1085
Pro Ser Pro Met Met Gln Arg Ile Ser Asp Arg Arg Gly Ser Gly Lys 
     1090                1095                1100
Pro Arg Pro Lys Ser Glu Gly Phe Glu Leu Tyr Asn Asn Ser Thr Gln 
 1105                1110                1115                1120
Asn Gly Ser Pro Glu Ser Pro Gln Leu Pro Trp Ala Glu Tyr Ser Glu 
                 1125                1130                1135
Pro Lys Lys Leu Pro Gly Asp Asp Arg Leu Met Lys Asn Arg Ala Asp 
             1140                1145                1150
His Arg Ser Ser Pro Asn Val Ala Asn Gln Pro Pro Ser Pro Gly Gly 
         1155                1160                1165
Lys Ser Ala Tyr Ala Ser Gly Thr Thr Ala Lys Ile Thr Ser Val Ser 
     1170                1175                1180
Thr Gly Asn Leu Cys Thr Glu Glu Gln Thr Pro Pro Pro Arg Pro Glu 
 1185                1190                1195                1200
Ala Tyr Pro Ile Pro Thr Gln Thr Tyr Thr Arg Glu Tyr Phe Thr Phe 
                 1205                1210                1215
Pro Ala Ser Lys Ser Gln Asp Arg Met Ala Pro Pro Gln Asn Gln Trp 
             1220                1225                1230
Pro Asn Tyr Glu Glu Lys Pro His Met His Thr Asp Ser Asn His Ser 
         1235                1240                1245
Ser Ile Ala Ile Gln Arg Val Thr Arg Ser Gln Glu Glu Leu Arg Glu 
     1250                1255                1260
Asp Lys Ala Tyr Gln Leu Glu Arg His Arg Ile Glu Ala Ala Met Asp 
 1265                1270                1275                1280
Arg Lys Ser Asp Ser Asp Met Trp Ile Asn Gln Ser Ser Ser Leu Asp 
                 1285                1290                1295
Ser Ser Thr Ser Ser Gln Glu His Leu Asn His Ser Ser Lys Ser Val 
             1300                1305                1310
Thr Pro Ala Ser Thr Leu Thr Lys Ser Gly Pro Gly Arg Trp Lys Thr 
         1315                1320                1325
Pro Ala Ala Ile Pro Ala Thr Pro Val Ala Val Ser Gln Pro Ile Arg 
     1330                1335                1340
Thr Asp Leu Pro Pro Pro Pro Pro Pro Pro Pro Val His Tyr Ala Gly 
 1345                1350                1355                1360
Asp Phe Asp Gly Met Ser Met Asp Leu Pro Leu Pro Pro Pro Pro Ser 
                 1365                1370                1375
Ala Asn Gln Ile Gly Leu Pro Ser Ala Gln Val Ala Ala Ala Glu Arg 
             1380                1385                1390
Arg Lys Arg Glu Glu His Gln Arg Trp Tyr Glu Lys Glu Lys Ala Arg 
         1395                1400                1405
Leu Glu Glu Glu Arg Glu Arg Lys Arg Arg Glu Gln Glu Arg Lys Leu 
     1410                1415                1420
Gly Gln Met Arg Thr Gln Ser Leu Asn Pro Ala Pro Phe Ser Pro Leu 
 1425                1430                1435                1440
Thr Ala Gln Gln Met Lys Pro Glu Lys Pro Ser Thr Leu Gln Arg Pro 
                 1445                1450                1455
Gln Glu Thr Val Ile Arg Glu Leu Gln Pro Gln Gln Gln Pro Arg Thr 
             1460                1465                1470
Ile Glu Arg Arg Asp Leu Gln Tyr Ile Thr Val Ser Lys Glu Glu Leu 
         1475                1480                1485
Ser Ser Gly Asp Ser Leu Ser Pro Asp Pro Trp Lys Arg Asp Ala Lys 
     1490                1495                1500
Glu Lys Leu Glu Lys Gln Gln Gln Met His Ile Val Asp Met Leu Ser 
 1505                1510                1515                1520
Lys Glu Ile Gln Glu Leu Gln Ser Lys Pro Asp Arg Ser Ala Glu Glu 
                 1525                1530                1535
Ser Asp Arg Leu Arg Lys Leu Met Leu Glu Trp Gln Phe Gln Lys Arg 
             1540                1545                1550
Leu Gln Glu Ser Lys Gln Lys Asp Glu Asp Asp Glu Glu Glu Glu Asp 
         1555                1560                1565
Asp Asp Val Asp Thr Met Leu Ile Met Gln Arg Leu Glu Ala Glu Arg 
     1570                1575                1580
Arg Ala Arg Leu Gln Asp Glu Glu Arg Arg Arg Gln Gln Gln Leu Glu 
 1585                1590                1595                1600
Glu Met Arg Lys Arg Glu Ala Glu Asp Arg Ala Arg Gln Glu Glu Glu 
                 1605                1610                1615
Arg Arg Arg Gln Glu Glu Glu Arg Thr Lys Arg Asp Ala Glu Glu Lys 
             1620                1625                1630
Arg Arg Gln Glu Glu Gly Tyr Tyr Ser Arg Leu Glu Ala Glu Arg Arg 
         1635                1640                1645
Arg Gln His Asp Glu Ala Ala Arg Arg Leu Leu Glu Pro Glu Ala Pro 
     1650                1655                1660
Gly Leu Cys Arg Pro Pro Leu Pro Arg Asp Tyr Glu Pro Pro Ser Pro 
 1665                1670                1675                1680
Ser Pro Ala Pro Gly Ala Pro Pro Pro Pro Pro Gln Arg Asn Ala Ser 
                 1685                1690                1695
Tyr Leu Lys Thr Gln Val Leu Ser Pro Asp Ser Leu Phe Thr Ala Lys 
             1700                1705                1710
Phe Val Ala Tyr Asn Glu Glu Glu Glu Glu Glu Asp Cys Ser Leu Ala 
         1715                1720                1725
Gly Gln Asp Lys Tyr Ser Ser Thr Arg Lys Ser His Gly Asp Leu Leu 
     1730                1735                1740
Pro Ala Pro Leu Lys Pro Arg Pro Pro Pro Cys Gln Pro Arg Pro Ala 
 1745                1750                1755                1760
Ser Asp Gly Val Phe Leu Ser Asn Ser Phe Gln Pro Pro Ser Ala Lys 
                 1765                1770                1775
Ala Asn Ser Thr Ala His Lys Lys Gly Gln Pro Leu Pro Pro Pro Lys 
             1780                1785                1790
Lys Ser Ser Ser Tyr His Pro Ser His Cys Lys Gly Arg Gly Lys Arg 
         1795                1800                1805
Val Thr Asn Gln Leu Ser Leu Ser 
     1810                1815



<210> 2342
<211> 1850
<212> DNA
<213> Rattus norvegicus
<308> D90404
<400> 2342

gaattccgg  tctagttgt  gttttctct  ccatctgct  tccgggcgc  gtcaaccat  60
ggtccgtgg  cccactcct  gcgcgccgc  ctgctgctg  tgcttttgg  agtctgcac  120
gtgagctcc  acactcctg  caactgcac  taccctgac  tgctgggta  ctgggtttt  180
caggtgggc  ctagacatc  ccgaagtca  attaactgc  cggtaatgg  accaacaga  240
gaaaaggta  tgatacacc  gaagaagtt  gatactgcc  atgatgaag  gggcaattc  300
gggtatttc  ccctcattt  caaccaagg  tttgagatt  tgttgaatg  ctacaagtg  360
tttgcgttt  tcaagtatg  agtcaaagg  agcagagcc  tcagttact  ccatgagac  420
atgacaggg  gggtccatg  tgtcctggg  cggaactgg  cttgctttg  tggcaagaa  480
atggcaaat  actctgaga  ggtttatgt  aatgtggca  accttggag  tctccagga  540
aaatattct  aaaggctct  cagtcacaa  cacaacttt  tgaaggcca  caattctgt  600
cagaagtct  ggactgcaa  cacctatga  gaatatgag  aactgagca  acgagattt  660
ataaggaga  gtggccaca  cggaaggat  ctaaggccc  aacctgccc  gataactga  720
gaaatacag  aacaaattt  aagtttgcc  gaatcttgg  actggagaa  cgtccgtgg  780
atcaatttt  ttagccctg  tcgaaacca  gaatcttgt  gaagctgct  ctcatttgc  840
tctctgggt  tgctagaag  aagaattcg  atattaacc  acaattctc  gaccccaat  900
ctgagtcct  aggaggttg  atcttgtag  ccgtatgcc  aaggttgtg  tggtggatt  960
ccatacctc  ttgcaggaa  gtatgccca  gattttggg  tggtggaag  aaactgctt  1020
ccctacaca  ccacagatg  tccatgcaa  ccaaaggaa  actgcctcc  ttactattc  1080
tctgagtac  actatgtgg  tggtttcta  ggtggctgc  atgaagccc  gatgaagct  1140
gagctggtc  aacacggac  catggcagt  gcctttgaa  tccacgatg  cttcctgca  1200
taccacagt  ggatctacc  ccacactgg  ctgagcgac  ctttcaacc  ctttgagct  1260
accaatcat  ctgttctgc  tgtgggcta  ggaaaagat  cagtcactg  gttagacta  1320
tggattgtc  agaacagct  gggctctca  tggggtgag  gtggctact  ccggatccg  1380
agaggaact  atgaatgtg  aattgagag  atagccatg  cagccatac  gattcctaa  1440
ttgtaggac  tagctccca  tgtcccata  agcttttta  tattcacag  gtgatttag  1500
cacaggctg  agactttta  aaagcaata  cagaagctt  ccactaggt  cccttaaag  1560
attttgccc  taagtttaa  acaatcctt  atttttttc  tttaatatc  tccctatca  1620
tcaccgaac  acttttctt  ttaaagtac  tggttaagt  atacttttc  gaggattgg  1680
tagatattg  caaatattt  tgctggtca  ctaaaatgc  gccagatgt  tcattgtta  1740
aaatctata  aaaagtgca  gctgccttt  ttaaattac  taaatccca  gaatacatg  1800
ccaaaatag  tatttttta  agactttaa  ataaatgat  aatcgatgct  1850



<210> 2343
<211> 462
<212> PRT
<213> Rattus norvegicus
<308> P80067
<400> 2343

Met Gly Pro Trp Thr His Ser Leu Arg Ala Ala Leu Leu Leu Val Leu 
  1               5                  10                  15
Leu Gly Val Cys Thr Val Ser Ser Asp Thr Pro Ala Asn Cys Thr Tyr 
             20                  25                  30
Pro Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Pro Arg His Pro 
         35                  40                  45
Arg Ser His Ile Asn Cys Ser Val Met Glu Pro Thr Glu Glu Lys Val 
     50                  55                  60
Val Ile His Leu Lys Lys Leu Asp Thr Ala Tyr Asp Glu Val Gly Asn 
 65                  70                  75                  80
Ser Gly Tyr Phe Thr Leu Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                 85                  90                  95
Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Tyr Glu Val Lys Gly Ser 
             100                105                110
Arg Ala Ile Ser Tyr Cys His Glu Thr Met Thr Gly Trp Val His Asp 
         115                120                125
Tyr Leu Gly Arg Asn Trp Ala Cys Phe Val Gly Lys Lys Met Ala Asn 
     130                135                140
His Ser Glu Lys Val Tyr Val Asn Val Ala His Leu Gly Gly Leu Gln 
 145                150                155                160
Glu Lys Tyr Ser Glu Arg Leu Tyr Ser His His His Asn Phe Val Lys 
                 165                170                175
Ala Ile Asn Ser Val Gln Lys Ser Trp Thr Ala Thr Thr Tyr Arg Arg 
             180                185                190
Tyr Glu Lys Leu Ser Ile Arg Asp Leu Ile Arg Arg Ser Gly His Ser 
         195                200                205
Gly Arg Ile Leu Arg Pro Lys Pro Ala Pro Ile Thr Asp Glu Ile Gln 
     210                215                220
Gln Gln Ile Leu Ser Leu Pro Glu Ser Trp Asp Trp Arg Asn Val Arg 
 225                230                235                240
Gly Ile Asn Phe Val Ser Pro Val Arg Asn Gln Glu Ser Cys Gly Ser 
                 245                250                255
Cys Tyr Ser Phe Ala Ser Ile Gly Met Leu Glu Ala Arg Ile Arg Ile 
             260                265                270
Leu Thr Asn Asn Ser Gln Thr Pro Ile Leu Ser Pro Gln Glu Val Val 
         275                280                285
Ser Cys Ser Pro Tyr Ala Gln Gly Cys Asp Gly Gly Phe Pro Tyr Leu 
     290                295                300
Ile Ala Gly Lys Tyr Ala Gln Asp Phe Gly Val Val Glu Glu Asn Cys 
 305                310                315                320
Phe Pro Tyr Thr Ala Thr Asp Ala Pro Cys Lys Pro Lys Glu Asn Cys 
                 325                330                335
Leu Arg Tyr Tyr Ser Ser Glu Tyr Tyr Tyr Val Gly Gly Phe Tyr Gly 
             340                345                350
Gly Cys Asn Glu Ala Leu Met Lys Leu Glu Leu Val Lys His Gly Pro 
         355                360                365
Met Ala Val Ala Phe Glu Val His Asp Asp Phe Leu His Tyr His Ser 
     370                375                380
Gly Ile Tyr His His Thr Gly Leu Ser Asp Pro Phe Asn Pro Phe Glu 
 385                390                395                400
Leu Thr Asn His Ala Val Leu Leu Val Gly Tyr Gly Lys Asp Pro Val 
                 405                410                415
Thr Gly Leu Asp Tyr Trp Ile Val Lys Asn Ser Trp Gly Ser Gln Trp 
             420                425                430
Gly Glu Ser Gly Tyr Phe Arg Ile Arg Arg Gly Thr Asp Glu Cys Ala 
         435                440                445
Ile Glu Ser Ile Ala Met Ala Ala Ile Pro Ile Pro Lys Leu 
     450                455                460



<210> 2344
<211> 304
<212> DNA
<213> Homo sapiens
<308> AA296068
<400> 2344

agcatcgat  aaatcattt  ttttaaagt  tttaaaaaa  aactatttt  gccatgtat  60
catgggatt  atgtaattt  aaaaaggng  ttgcacttt  atatagntt  ttaacaatg  120
aacatctgg  tgcatttta  gngaccngc  aaaatattt  acaatatct  accaatccn  180
agaaaagta  tacttaacc  agtacttta  aaagnaaag  agttcggtg  ttgataggg  240
ggntattaa  aggnaaaaa  caaggnttg  tttaaactt  agggcaaaa  tctttaagg  300
tacc  304



<210> 2345
<211> 1850
<212> DNA
<213> Rattus norvegicus
<308> D90404
<400> 2345

gaattccgg  tctagttgt  gttttctct  ccatctgct  tccgggcgc  gtcaaccat  60
ggtccgtgg  cccactcct  gcgcgccgc  ctgctgctg  tgcttttgg  agtctgcac  120
gtgagctcc  acactcctg  caactgcac  taccctgac  tgctgggta  ctgggtttt  180
caggtgggc  ctagacatc  ccgaagtca  attaactgc  cggtaatgg  accaacaga  240
gaaaaggta  tgatacacc  gaagaagtt  gatactgcc  atgatgaag  gggcaattc  300
gggtatttc  ccctcattt  caaccaagg  tttgagatt  tgttgaatg  ctacaagtg  360
tttgcgttt  tcaagtatg  agtcaaagg  agcagagcc  tcagttact  ccatgagac  420
atgacaggg  gggtccatg  tgtcctggg  cggaactgg  cttgctttg  tggcaagaa  480
atggcaaat  actctgaga  ggtttatgt  aatgtggca  accttggag  tctccagga  540
aaatattct  aaaggctct  cagtcacaa  cacaacttt  tgaaggcca  caattctgt  600
cagaagtct  ggactgcaa  cacctatga  gaatatgag  aactgagca  acgagattt  660
ataaggaga  gtggccaca  cggaaggat  ctaaggccc  aacctgccc  gataactga  720
gaaatacag  aacaaattt  aagtttgcc  gaatcttgg  actggagaa  cgtccgtgg  780
atcaatttt  ttagccctg  tcgaaacca  gaatcttgt  gaagctgct  ctcatttgc  840
tctctgggt  tgctagaag  aagaattcg  atattaacc  acaattctc  gaccccaat  900
ctgagtcct  aggaggttg  atcttgtag  ccgtatgcc  aaggttgtg  tggtggatt  960
ccatacctc  ttgcaggaa  gtatgccca  gattttggg  tggtggaag  aaactgctt  1020
ccctacaca  ccacagatg  tccatgcaa  ccaaaggaa  actgcctcc  ttactattc  1080
tctgagtac  actatgtgg  tggtttcta  ggtggctgc  atgaagccc  gatgaagct  1140
gagctggtc  aacacggac  catggcagt  gcctttgaa  tccacgatg  cttcctgca  1200
taccacagt  ggatctacc  ccacactgg  ctgagcgac  ctttcaacc  ctttgagct  1260
accaatcat  ctgttctgc  tgtgggcta  ggaaaagat  cagtcactg  gttagacta  1320
tggattgtc  agaacagct  gggctctca  tggggtgag  gtggctact  ccggatccg  1380
agaggaact  atgaatgtg  aattgagag  atagccatg  cagccatac  gattcctaa  1440
ttgtaggac  tagctccca  tgtcccata  agcttttta  tattcacag  gtgatttag  1500
cacaggctg  agactttta  aaagcaata  cagaagctt  ccactaggt  cccttaaag  1560
attttgccc  taagtttaa  acaatcctt  atttttttc  tttaatatc  tccctatca  1620
tcaccgaac  acttttctt  ttaaagtac  tggttaagt  atacttttc  gaggattgg  1680
tagatattg  caaatattt  tgctggtca  ctaaaatgc  gccagatgt  tcattgtta  1740
aaatctata  aaaagtgca  gctgccttt  ttaaattac  taaatccca  gaatacatg  1800
ccaaaatag  tatttttta  agactttaa  ataaatgat  aatcgatgct  1850



<210> 2346
<211> 462
<212> PRT
<213> Rattus norvegicus
<308> P80067
<400> 2346

Met Gly Pro Trp Thr His Ser Leu Arg Ala Ala Leu Leu Leu Val Leu 
  1               5                  10                  15
Leu Gly Val Cys Thr Val Ser Ser Asp Thr Pro Ala Asn Cys Thr Tyr 
             20                  25                  30
Pro Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Pro Arg His Pro 
         35                  40                  45
Arg Ser His Ile Asn Cys Ser Val Met Glu Pro Thr Glu Glu Lys Val 
     50                  55                  60
Val Ile His Leu Lys Lys Leu Asp Thr Ala Tyr Asp Glu Val Gly Asn 
 65                  70                  75                  80
Ser Gly Tyr Phe Thr Leu Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                 85                  90                  95
Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Tyr Glu Val Lys Gly Ser 
             100                105                110
Arg Ala Ile Ser Tyr Cys His Glu Thr Met Thr Gly Trp Val His Asp 
         115                120                125
Tyr Leu Gly Arg Asn Trp Ala Cys Phe Val Gly Lys Lys Met Ala Asn 
     130                135                140
His Ser Glu Lys Val Tyr Val Asn Val Ala His Leu Gly Gly Leu Gln 
 145                150                155                160
Glu Lys Tyr Ser Glu Arg Leu Tyr Ser His His His Asn Phe Val Lys 
                 165                170                175
Ala Ile Asn Ser Val Gln Lys Ser Trp Thr Ala Thr Thr Tyr Arg Arg 
             180                185                190
Tyr Glu Lys Leu Ser Ile Arg Asp Leu Ile Arg Arg Ser Gly His Ser 
         195                200                205
Gly Arg Ile Leu Arg Pro Lys Pro Ala Pro Ile Thr Asp Glu Ile Gln 
     210                215                220
Gln Gln Ile Leu Ser Leu Pro Glu Ser Trp Asp Trp Arg Asn Val Arg 
 225                230                235                240
Gly Ile Asn Phe Val Ser Pro Val Arg Asn Gln Glu Ser Cys Gly Ser 
                 245                250                255
Cys Tyr Ser Phe Ala Ser Ile Gly Met Leu Glu Ala Arg Ile Arg Ile 
             260                265                270
Leu Thr Asn Asn Ser Gln Thr Pro Ile Leu Ser Pro Gln Glu Val Val 
         275                280                285
Ser Cys Ser Pro Tyr Ala Gln Gly Cys Asp Gly Gly Phe Pro Tyr Leu 
     290                295                300
Ile Ala Gly Lys Tyr Ala Gln Asp Phe Gly Val Val Glu Glu Asn Cys 
 305                310                315                320
Phe Pro Tyr Thr Ala Thr Asp Ala Pro Cys Lys Pro Lys Glu Asn Cys 
                 325                330                335
Leu Arg Tyr Tyr Ser Ser Glu Tyr Tyr Tyr Val Gly Gly Phe Tyr Gly 
             340                345                350
Gly Cys Asn Glu Ala Leu Met Lys Leu Glu Leu Val Lys His Gly Pro 
         355                360                365
Met Ala Val Ala Phe Glu Val His Asp Asp Phe Leu His Tyr His Ser 
     370                375                380
Gly Ile Tyr His His Thr Gly Leu Ser Asp Pro Phe Asn Pro Phe Glu 
 385                390                395                400
Leu Thr Asn His Ala Val Leu Leu Val Gly Tyr Gly Lys Asp Pro Val 
                 405                410                415
Thr Gly Leu Asp Tyr Trp Ile Val Lys Asn Ser Trp Gly Ser Gln Trp 
             420                425                430
Gly Glu Ser Gly Tyr Phe Arg Ile Arg Arg Gly Thr Asp Glu Cys Ala 
         435                440                445
Ile Glu Ser Ile Ala Met Ala Ala Ile Pro Ile Pro Lys Leu 
     450                455                460



<210> 2347
<211> 304
<212> DNA
<213> Homo sapiens
<308> AA296068
<400> 2347

agcatcgat  aaatcattt  ttttaaagt  tttaaaaaa  aactatttt  gccatgtat  60
catgggatt  atgtaattt  aaaaaggng  ttgcacttt  atatagntt  ttaacaatg  120
aacatctgg  tgcatttta  gngaccngc  aaaatattt  acaatatct  accaatccn  180
agaaaagta  tacttaacc  agtacttta  aaagnaaag  agttcggtg  ttgataggg  240
ggntattaa  aggnaaaaa  caaggnttg  tttaaactt  agggcaaaa  tctttaagg  300
tacc  304



<210> 2348
<211> 2696
<212> DNA
<213> Rattus norvegicus
<308> E00717
<400> 2348

catcctccc  ggggtccta  agaacactc  tcagttcag  ccttcctca  agccaaagc  60
gccacctag  tcatgcctt  tgtgtatgg  ttcccagcc  tcacatcag  cacagagct  120
ctcctggcc  tcaccacat  ctgccttgg  ttctgggtg  ttagagtca  aagaacctg  180
gttcccaaa  gtctgaaga  tccacccgg  ccctggggc  tgcccttca  agggcacgt  240
ctgaccctg  ggaagaacc  acacctgtc  ctgacaaaa  tgagtcagc  gtatgggga  300
gtgctgcag  tccgtattg  ctccacacc  gtggtggtg  tgagcggcc  gaacaccat  360
aagcaggcc  tggtgaaac  gggggatga  ttcaaaggc  ggccagacc  ctacagctt  420
acacttatc  ctaatggcc  gagcatgac  ttcaaccca  actctggac  gctgtgggc  480
gcccgccgg  gcctggccc  gaatgcgct  aagagtttc  ccatagcct  agacccaac  540
ctggcatcc  cttgctact  ggaagagca  gtgagcaaa  aggctgaat  cttaatcag  600
aagttccag  agctgatgg  agaggttgg  cacttcgac  ctttcaagt  tttggtggt  660
tcagtggcc  atgtcatct  tgccatatg  tttggcaga  gttatgacc  cgatgacca  720
gagctgctc  gcatagtca  tctaagcaa  gagtttggg  aggttactg  ttctggata  780
ccagctgac  tcattccta  cctccgtta  ctccctaac  cttccctgg  tgccttcaa  840
gacttgaat  agaagttct  cagtttcat  aagaagcta  tcaaagagc  ctacaggac  900
tttgagaag  gccacatcc  ggacatcac  gacagcctc  ttgagcatt  tcaggacag  960
aggctggac  agaatgcca  tgtccagct  tcagatgat  aggtcatta  gattgtttt  1020
gacctcttt  gagctgggt  tgacacaat  acaactgct  tctcttgga  cctcatgta  1080
ctggtaacc  accctagga  acagagaaa  atccaggag  agttagaca  agtgattgg  1140
agggatcgg  agccccggc  ttctgacag  cctcagctg  cctatctgg  ggccttcat  1200
ctggagacc  tccgacatt  atcctttgt  ccattcacc  tcccccaca  caccataag  1260
gatacaagt  tgaatggct  ctatatccc  aagggacac  gtgtctttg  gaaccagtg  1320
caggttaac  atgaccagg  actatgggg  gatccaaac  agttccggc  tgaaaggtt  1380
cttacctcc  gtggcactc  ggacaaaca  ctgagtgag  aggtcattc  ctttggttt  1440
ggcaagcga  agtgcattg  ggagaccat  ggccgactg  aggtctttc  cttcctggc  1500
atcttgctg  agcaaatgg  atttaatgt  tcaccaggc  agaaggtgg  tatgactcc  1560
gcctatggg  tgactttaa  acatgcccg  tgtgagcac  tccaagtgc  gatgcggtc  1620
tctggtcct  agcatctcc  ggcttagac  gtcctggat  ctcaccaga  caggtggct  1680
ttcctagga  tcaacttca  tcagaaaca  agaccctgg  gcattgtgc  tgcctccta  1740
tttggactt  tttctctat  tgctgaaca  agacactgg  cacagcaga  acccacagg  1800
acctcagat  cttctcaag  tcagcatca  ctaggagac  taaaagggt  atgagatac  1860
tgggcctca  aaaacccct  aagagctct  taggtcctc  agtggctgg  tggtttgaa  1920
aatacttac  acaggtcat  ccaggatct  gctggttac  ttgacaacc  ggagtagcc  1980
agaatggag  gagaagaga  ctcaaaata  tggcacgga  gtgctcttg  catctgctg  2040
ggctcaact  tcttccaac  tgggtttat  acactacat  tgggggtgt  gcaccttca  2100
ttaccctac  tagaaataa  caaggtctc  ttgtccttg  aaagcccat  ttcctgttt  2160
ggaagggct  agagttgtg  gtagaaaga  ctaagaaca  agggacaga  tttctgggc  2220
gtaagacca  gtttagagt  aaggaatgc  ttttgagac  gtattgtgt  gtccaggct  2280
cctctgaac  tgctaccaa  ggtggcctt  aactcctta  ttctttttt  tgcttttac  2340
accctacca  gtgctaggg  acagtcatg  accgctaca  cagctcttg  tctcttgtc  2400
ttactgtat  aaacgtttc  ttctttctt  tttttttaa  gaaaatgtt  gtgcataag  2460
gttttttat  gtggcctgt  ttttgctta  gcatttgta  tagtcgtac  tcaatagat  2520
tagataatt  gcttagtgt  atagagaaa  atctaactc  agtatccag  aatatatag  2580
aaaaacgta  ctgagctaa  taaaaatat  acctggaaa  aaaaaaaaa  aaaaaaaaa  2640
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaa  2696



<210> 2349
<211> 524
<212> PRT
<213> Rattus norvegicus
<308> CAA25153
<400> 2349

Met Pro Ser Val Tyr Gly Phe Pro Ala Phe Thr Ser Ala Thr Glu Leu 
  1               5                  10                  15
Leu Leu Ala Val Thr Thr Phe Cys Leu Gly Phe Trp Val Val Arg Val 
             20                  25                  30
Thr Arg Thr Trp Val Pro Lys Gly Leu Lys Ser Pro Pro Gly Pro Trp 
         35                  40                  45
Gly Leu Pro Phe Ile Gly His Val Leu Thr Leu Gly Lys Asn Pro His 
     50                  55                  60
Leu Ser Leu Thr Lys Leu Ser Gln Gln Tyr Gly Asp Val Leu Gln Ile 
 65                  70                  75                  80
Arg Ile Gly Ser Thr Pro Val Val Val Leu Ser Gly Leu Asn Thr Ile 
                 85                  90                  95
Lys Gln Ala Leu Val Lys Gln Gly Asp Asp Phe Lys Gly Arg Pro Asp 
             100                105                110
Leu Tyr Ser Phe Thr Leu Ile Ala Asn Gly Gln Ser Met Thr Phe Asn 
         115                120                125
Pro Asp Ser Gly Pro Leu Trp Ala Ala Arg Arg Arg Leu Ala Gln Asn 
     130                135                140
Ala Leu Lys Ser Phe Ser Ile Ala Ser Asp Pro Thr Leu Ala Ser Ser 
 145                150                155                160
Cys Tyr Leu Glu Glu His Val Ser Lys Glu Ala Glu Tyr Leu Ile Ser 
                 165                170                175
Lys Phe Gln Lys Leu Met Ala Glu Val Gly His Phe Asp Pro Phe Lys 
             180                185                190
Tyr Leu Val Val Ser Val Ala Asn Val Ile Cys Ala Ile Cys Phe Gly 
         195                200                205
Arg Arg Tyr Asp His Asp Asp Gln Glu Leu Leu Ser Ile Val Asn Leu 
     210                215                220
Ser Asn Glu Phe Gly Glu Val Thr Gly Ser Gly Tyr Pro Ala Asp Phe 
 225                230                235                240
Ile Pro Ile Leu Arg Tyr Leu Pro Asn Ser Ser Leu Asp Ala Phe Lys 
                 245                250                255
Asp Leu Asn Lys Lys Phe Tyr Ser Phe Met Lys Lys Leu Ile Lys Glu 
             260                265                270
His Tyr Arg Thr Phe Glu Lys Gly His Ile Arg Asp Ile Thr Asp Ser 
         275                280                285
Leu Ile Glu His Cys Gln Asp Arg Arg Leu Asp Glu Asn Ala Asn Val 
     290                295                300
Gln Leu Ser Asp Asp Lys Val Ile Thr Ile Val Phe Asp Leu Phe Gly 
 305                310                315                320
Ala Gly Phe Asp Thr Ile Thr Thr Ala Ile Ser Trp Ser Leu Met Tyr 
                 325                330                335
Leu Val Thr Asn Pro Arg Ile Gln Arg Lys Ile Gln Glu Glu Leu Asp 
             340                345                350
Thr Val Ile Gly Arg Asp Arg Gln Pro Arg Leu Ser Asp Arg Pro Gln 
         355                360                365
Leu Pro Tyr Leu Glu Ala Phe Ile Leu Glu Thr Phe Arg His Ser Ser 
     370                375                380
Phe Val Pro Phe Thr Ile Pro His Ser Thr Ile Arg Asp Thr Ser Leu 
 385                390                395                400
Asn Gly Phe Tyr Ile Pro Lys Gly His Cys Val Phe Val Asn Gln Trp 
                 405                410                415
Gln Val Asn His Asp Gln Glu Leu Trp Gly Asp Pro Asn Glu Phe Arg 
             420                425                430
Pro Glu Arg Phe Leu Thr Ser Ser Gly Thr Leu Asp Lys His Leu Ser 
         435                440                445
Glu Lys Val Ile Leu Phe Gly Leu Gly Lys Arg Lys Cys Ile Gly Glu 
     450                455                460
Thr Ile Gly Arg Leu Glu Val Phe Leu Phe Leu Ala Ile Leu Leu Gln 
 465                470                475                480
Gln Met Glu Phe Asn Val Ser Pro Gly Glu Lys Val Asp Met Thr Pro 
                 485                490                495
Ala Tyr Gly Leu Thr Leu Lys His Ala Arg Cys Glu His Phe Gln Val 
             500                505                510
Gln Met Arg Ser Ser Gly Pro Gln His Leu Gln Ala 
         515                520



<210> 2350
<211> 2602
<212> DNA
<213> Homo sapiens
<308> NM_000499
<400> 2350

ctcaccctg  aggtgacag  tccttggaa  cttccctga  ccttgtgat  ccaggctcc  60
agagtccac  cttcccagc  cagctcagt  cctcagcca  ctccaagat  cctacactg  120
tcatgcttt  cccaatctc  atgtcggcc  cggagtttc  tctggcctc  gtcatcttc  180
gtctggtat  ctgggtaat  agggcctca  gacctcagg  ccccaaagg  ctgaagaat  240
caccagggc  atggggctg  cctctgatt  ggcacatgc  gaccctggg  aagaacccg  300
acctggcac  gtcaaggat  agccagcag  atggggacg  gctgcagat  cgaattggc  360
ccacacccg  ggtggtgct  agcggcctg  acaccatcc  gcaggccct  gtgcggcag  420
gcgatgatt  caagggccg  cccgacctc  acaccttca  cctcatcag  aatggtcag  480
gcatgtcct  cagcccaga  tctggacca  tgtgggctg  ccgccggcg  ctggcccag  540
atggcctga  aagtttctc  attgcctct  acccagcct  ctcaacctc  tgctacctg  600
aagagcatg  gagcaagga  gctgaggtc  tgataagca  gttgcagga  ctgatggca  660
ggcctgggc  ctttaaccc  tacaggtat  tggtggtat  agtgaccaa  gtcatctgt  720
ccatttgct  tggccggcg  tatgaccac  accaccaag  actgcttag  ctagtcaac  780
tgaataata  tttcgggga  gtggttggc  ctggaaacc  agctgactt  atccctatt  840
ttcgctacc  acccaaccc  tccctgaat  ccttcaagg  cctgaatga  aagttctac  900
gcttcatgc  gaagatggt  aaggagcac  acaaaacct  tgagaaggg  cacatccgg  960
acatcacag  cagcctgat  gagcactgt  aggagaagc  gctggatga  aacgccaat  1020
tccagctgt  agatgagaa  atcattaac  tcgtcttgg  cctctttgg  gctgggttt  1080
acacagtca  aactgctat  tcctggagc  tcatgtatt  ggtgatgaa  cccagggta  1140
agagaaaga  ccaagagga  ctagacaca  tgattggca  gtcacggcg  ccccggctc  1200
ctgacagat  ccatctgcc  tatatggag  ccttcatcc  ggagacctt  cgacactct  1260
ccttcgtcc  cttcaccat  ccccacagc  caacaagag  cacaagttt  aaaggcttt  1320
acatcccca  ggggcgttg  gtctttgta  accagtggc  gatcaacca  gaccagaag  1380
tatgggtca  cccatctga  ttcctacct  aacggtttc  cacccctga  ggtgctatc  1440
acaaggtgt  aagtgagaa  gtgattatc  ttggcatgg  caagcggaa  tgtatcggt  1500
agaccattg  ccgctggga  gtctttctc  tcctggcta  cctgctgca  cgggtggaa  1560
tcagcgtgc  actgggcgt  aaggtggac  tgaccccca  ctatgggct  accatgaag  1620
atgcctgct  tgagcactt  caaatgcag  tgcgctctt  ggtgcttga  agccctgag  1680
cctagactc  gtctacctg  tctggttgg  cagccagac  agcaggctg  cctatgtgg  1740
ctaagattc  gcctgaaac  catagacac  gatctggct  cagttttgc  atctgggct  1800
tgggcaagc  taagggatc  tgcctgccc  taccctgga  ttgcctctg  acaccctcc  1860
gagacaaca  gtaaaacag  gccacatag  tgctgatgg  gccttccca  gttgtgctt  1920
agccaggag  cctgctagg  ttaggaggt  cttaggcct  tgagaagct  tgaagaact  1980
tctggaagc  cctgggccc  gtacctagc  ggctctgtg  gggtgctga  tggcttcag  2040
aagttagaa  tagccaaac  aggaccctg  ccaatcttt  acaattggg  gctgccaag  2100
gtgaaggga  gagacagcc  aggatactg  cacagaggt  gtctcactg  ttgaactag  2160
ctgagcaat  tgaccctat  ggtctagga  acagttcct  ggaacatca  attcctctg  2220
ccttcctgc  ggcaggaac  aacagggct  ccttctggc  ttgtaagac  cttattgct  2280
tcctggagg  gctggggac  tgtgtctgc  gggatccag  gcgcacagg  agtgcacat  2340
tccaggcac  aggactagg  ctggagtga  gggggggta  ttcaattac  ttctattgg  2400
ctcccttct  tacactctt  taataaaat  tctattttt  atgtttgta  acaacaatc  2460
ttctattct  gcctgcatt  agcttgcat  cttgcataa  agcttaaga  ccattgatt  2520
aatgtaata  ggaaaattc  aacccaggt  tccaaaaat  tgtaagaac  actacctga  2580
ctaaataaa  atattgttc  ga  2602



<210> 2351
<211> 512
<212> PRT
<213> Homo sapiens
<308> P04798
<400> 2351

Met Leu Phe Pro Ile Ser Met Ser Ala Thr Glu Phe Leu Leu Ala Ser 
  1               5                  10                  15
Val Ile Phe Cys Leu Val Phe Trp Val Ile Arg Ala Ser Arg Pro Gln 
             20                  25                  30
Val Pro Lys Gly Leu Lys Asn Pro Pro Gly Pro Trp Gly Trp Pro Leu 
         35                  40                  45
Ile Gly His Met Leu Thr Leu Gly Lys Asn Pro His Leu Ala Leu Ser 
     50                  55                  60
Arg Met Ser Gln Gln Tyr Gly Asp Val Leu Gln Ile Arg Ile Gly Ser 
 65                  70                  75                  80
Thr Pro Val Val Val Leu Ser Gly Leu Asp Thr Ile Arg Gln Ala Leu 
                 85                  90                  95
Val Arg Gln Gly Asp Asp Phe Lys Gly Arg Pro Asp Leu Tyr Thr Phe 
             100                105                110
Thr Leu Ile Ser Asn Gly Gln Ser Met Ser Phe Ser Pro Asp Ser Gly 
         115                120                125
Pro Val Trp Ala Ala Arg Arg Arg Leu Ala Gln Asn Gly Leu Lys Ser 
     130                135                140
Phe Ser Ile Ala Ser Asp Pro Ala Ser Ser Thr Ser Cys Tyr Leu Glu 
 145                150                155                160
Glu His Val Ser Lys Glu Ala Glu Val Leu Ile Ser Thr Leu Gln Glu 
                 165                170                175
Leu Met Ala Gly Pro Gly His Phe Asn Pro Tyr Arg Tyr Val Val Val 
             180                185                190
Ser Val Thr Asn Val Ile Cys Ala Ile Cys Phe Gly Arg Arg Tyr Asp 
         195                200                205
His Asn His Gln Glu Leu Leu Ser Leu Val Asn Leu Asn Asn Asn Phe 
     210                215                220
Gly Glu Val Val Gly Ser Gly Asn Pro Ala Asp Phe Ile Pro Ile Leu 
 225                230                235                240
Arg Tyr Leu Pro Asn Pro Ser Leu Asn Ala Phe Lys Asp Leu Asn Glu 
                 245                250                255
Lys Phe Tyr Ser Phe Met Gln Lys Met Val Lys Glu His Tyr Lys Thr 
             260                265                270
Phe Glu Lys Gly His Ile Arg Asp Ile Thr Asp Ser Leu Ile Glu His 
         275                280                285
Cys Gln Glu Lys Gln Leu Asp Glu Asn Ala Asn Val Gln Leu Ser Asp 
     290                295                300
Glu Lys Ile Ile Asn Ile Val Leu Asp Leu Phe Gly Ala Gly Phe Asp 
 305                310                315                320
Thr Val Thr Thr Ala Ile Ser Trp Ser Leu Met Tyr Leu Val Met Asn 
                 325                330                335
Pro Arg Val Gln Arg Lys Ile Gln Glu Glu Leu Asp Thr Val Ile Gly 
             340                345                350
Arg Ser Arg Arg Pro Arg Leu Ser Asp Arg Ser His Leu Pro Tyr Met 
         355                360                365
Glu Ala Phe Ile Leu Glu Thr Phe Arg His Ser Ser Phe Val Pro Phe 
     370                375                380
Thr Ile Pro His Ser Thr Thr Arg Asp Thr Ser Leu Lys Gly Phe Tyr 
 385                390                395                400
Ile Pro Lys Gly Arg Cys Val Phe Val Asn Gln Trp Gln Ile Asn His 
                 405                410                415
Asp Gln Lys Leu Trp Val Asn Pro Ser Glu Phe Leu Pro Glu Arg Phe 
             420                425                430
Leu Thr Pro Asp Gly Ala Ile Asp Lys Val Leu Ser Glu Lys Val Ile 
         435                440                445
Ile Phe Gly Met Gly Lys Arg Lys Cys Ile Gly Glu Thr Ile Ala Arg 
     450                455                460
Trp Glu Val Phe Leu Phe Leu Ala Ile Leu Leu Gln Arg Val Glu Phe 
 465                470                475                480
Ser Val Pro Leu Gly Val Lys Val Asp Met Thr Pro Ile Tyr Gly Leu 
                 485                490                495
Thr Met Lys His Ala Cys Cys Glu His Phe Gln Met Gln Leu Arg Ser 
             500                505                510



<210> 2353
<211> 1601
<212> DNA
<213> Homo sapiens
<308> X74818
<400> 2353

aagggcccc  aatttaaaa  gcctgacct  cacctcaag  caccgaaga  ctctatgcc  720
gaagttgac  tgaatctga  aggtccaaa  atgaagggc  acgtggacg  ttctctgcc  780
aaagtggaa  gcgacctca  gggccctga  gttgacgtc  agggcccca  agtggacat  840
gatgtccca  atgtggacg  tcaaggccc  gactggcac  taaaaatgc  caaagtgaa  900
atgcccaag  tcagcatgc  tggcttcaa  ggagagggc  cagatgtgg  tgtgaacct  960
cccaaggct  accttgacg  ctcaggacc  aaggtggac  ttgatgttc  tgatgtgaa  1020
atcgaaggt  cagatgcga  actaaaggg  cctaaattc  agatgcctg  gatgaacat  1080
aaagccccc  agatctcca  gcctgactt  gatttgcat  tgaaaggtc  caaggtgaa  1140
ggtgatgtg  atgtttccc  tcctaaagt  gaaggtgac  tcaagggcc  agaagttga  1200
atcaagggc  ccaaagtgg  catcgatgc  cctgatgta  atgttcatg  cccagactg  1260
cacctgaag  tgcccaagg  gaaaatgcc  aaattcagc  tgccaggat  caaaggaga  1320
ggcccagat  tggatgtta  ccttcctaa  gctgacatt  agatttctg  ccccaaagt  1380
gacattgat  cccctgatg  cagtatcga  ggtccagat  caaaactca  gggtccaaa  1440
ttcaagatg  cagagatga  catcaaggc  cccaaaatc  ccatgcctg  cattgactt  1500
aacttgaag  gtcccaaag  gaaaggtga  gtggatgtc  ctctgccca  agtggaagg  1560
gatctcaag  gccctgaaa  tgacataaa  ggccccagt  t  1601



<210> 2354
<211> 534
<212> PRT
<213> Homo sapiens
<308> CAA52817
<400> 2354

Lys Gly Pro Lys Phe Lys Met Pro Asp Leu His Leu Lys Ala Pro Lys 
  1               5                  10                  15
Ile Ser Met Pro Glu Val Asp Leu Asn Leu Lys Gly Pro Lys Met Lys 
             20                  25                  30
Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp Leu Lys Gly 
         35                  40                  45
Pro Glu Val Asp Val Lys Gly Pro Lys Val Asp Ile Asp Val Pro Asp 
     50                  55                  60
Val Asp Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys 
 65                  70                  75                  80
Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val 
                 85                  90                  95
Asp Val Asn Leu Pro Lys Ala Asp Leu Asp Val Ser Gly Pro Lys Val 
             100                105                110
Asp Ile Asp Val Pro Asp Val Asn Ile Glu Gly Pro Asp Ala Lys Leu 
         115                120                125
Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro Lys 
     130                135                140
Ile Ser Met Pro Asp Phe Asp Leu His Leu Lys Gly Pro Lys Val Lys 
 145                150                155                160
Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp Leu Lys Gly 
                 165                170                175
Pro Glu Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asp Ala Pro Asp 
             180                185                190
Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys 
         195                200                205
Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val 
     210                215                220
Asp Val Thr Leu Pro Lys Ala Asp Ile Glu Ile Ser Gly Pro Lys Val 
 225                230                235                240
Asp Ile Asp Ala Pro Asp Val Ser Ile Glu Gly Pro Asp Ala Lys Leu 
                 245                250                255
Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro Lys 
             260                265                270
Ile Ser Met Pro Asp Ile Asp Phe Asn Leu Lys Gly Pro Lys Val Lys 
         275                280                285
Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp Leu Lys Gly 
     290                295                300
Pro Glu Ile Asp Ile Lys Gly Pro Ser Leu Asp Ile Asp Thr Pro Asp 
 305                310                315                320
Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys 
                 325                330                335
Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Phe 
             340                345                350
Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Ser 
         355                360                365
Leu Pro Lys Val Glu Ser Asp Leu Lys Gly Pro Glu Val Asp Ile Glu 
     370                375                380
Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Asp Val 
 385                390                395                400
His Phe Lys Ser Pro Gln Ile Ser Met Ser Asp Ile Asp Leu Asn Leu 
                 405                410                415
Lys Gly Pro Lys Ile Lys Gly Asp Met Asp Ile Ser Val Pro Lys Leu 
             420                425                430
Glu Gly Asp Leu Lys Gly Pro Lys Val Asp Val Lys Gly Pro Lys Val 
         435                440                445
Gly Ile Asp Thr Pro Asp Ile Asp Ile His Gly Pro Glu Gly Lys Leu 
     450                455                460
Lys Gly Pro Lys Phe Lys Met Pro Asp Leu His Leu Lys Ala Pro Lys 
 465                470                475                480
Ile Ser Met Pro Glu Val Asp Leu Asn Leu Lys Gly Pro Lys Val Lys 
                 485                490                495
Gly Asp Met Asp Ile Ser Leu Pro Lys Val Glu Gly Asp Leu Lys Gly 
             500                505                510
Pro Glu Val Asp Ile Arg Asp Pro Lys Val Asp Ile Asp Val Pro Asp 
         515                520                525
Val Asp Val Gln Gly Pro 
     530



<210> 2355
<211> 1223
<212> DNA
<213> Rattus norvegicus
<308> E01415
<400> 2355

agaccccag  accatgccc  tgacactgg  ttactggga  atccgtggg  tagcgcatg  60
catccgcct  ctcctggaa  acacagact  gagctatga  gagaagaga  acaccatgg  120
agacgctcc  gactttgac  gaagccagt  gctgaatga  aagttcaaa  tgggcctgg  180
cttccccaa  ctgccctac  taattgatg  atcacacaa  atcacccag  gcaatgcca  240
cctgcgcta  cttggccgc  agcacaacc  gtgtgggga  acagaagag  agaggattc  300
tgtggacat  ctggagaat  agctcatgg  caaccgcat  gtgctggcg  gactttgct  360
taaccctga  tttgagaag  tgaagccag  gtacctgga  caactgcct  gaatgatgc  420
gctttactc  gagttcctg  gcaagcggc  atggtttgc  ggggacaag  tcacctttg  480
ggatttcat  gcttacgat  ttcttgaga  gaaccaagt  tttgaggcc  cgtgcctgg  540
cgcgttccc  aacctgaag  atttcatag  gcgctttga  ggcctgaag  agatctccg  600
ctacatgaa  tccagccgc  tcctcccaa  acctctgtt  acaaagatg  ctatttggg  660
cagcaagta  gaccctgac  ggtgggctt  aggagaaag  taccaaatc  cctgggttt  720
ccaagagcc  taaggagcg  gcaggattc  tgagcccca  agccatgtt  tcttccttc  780
ttccattcc  gtccccaag  cttaccagc  ctcattttt  ggtcatcaa  ttcctgcca  840
acacaggct  ttaaaagcc  tagcaactc  tttccatta  caaaatagc  ttctaaagt  900
aaagtgccc  gcccccacc  ctcgagctc  tgtgattgg  tagttggct  ccaacatgt  960
attattttg  gcaggtcag  ctccccggc  gatggggtc  atctggaga  agtagattg  1020
tagcagctt  gaccaccgt  gccaagccc  tcttcttgc  gtttcccga  actagctat  1080
agcaaggtg  gctgtgtcc  cagcacttg  cactgcctc  gtaacccgc  cctaccgct  1140
tttcttcct  ctgctgtga  ctgtacctc  tgaccacaa  ccagaataa  tcattctcc  1200
cttaaaaaa  aaaaaaaaa  aaa  1223



<210> 2356
<211> 218
<212> PRT
<213> Rattus norvegicus
<308> NP_112416
<400> 2356

Met Pro Met Thr Leu Gly Tyr Trp Asp Ile Arg Gly Leu Ala His Ala 
  1               5                  10                  15
Ile Arg Leu Leu Leu Glu Tyr Thr Asp Ser Ser Tyr Glu Glu Lys Arg 
             20                  25                  30
Tyr Thr Met Gly Asp Ala Pro Asp Phe Asp Arg Ser Gln Trp Leu Asn 
         35                  40                  45
Glu Lys Phe Lys Leu Gly Leu Asp Phe Pro Asn Leu Pro Tyr Leu Ile 
     50                  55                  60
Asp Gly Ser His Lys Ile Thr Gln Ser Asn Ala Ile Leu Arg Tyr Leu 
 65                  70                  75                  80
Gly Arg Lys His Asn Leu Cys Gly Glu Thr Glu Glu Glu Arg Ile Arg 
                 85                  90                  95
Val Asp Ile Leu Glu Asn Gln Leu Met Asp Asn Arg Met Val Leu Ala 
             100                105                110
Arg Leu Cys Tyr Asn Pro Asp Phe Glu Lys Leu Lys Pro Gly Tyr Leu 
         115                120                125
Glu Gln Leu Pro Gly Met Met Arg Leu Tyr Ser Glu Phe Leu Gly Lys 
     130                135                140
Arg Pro Trp Phe Ala Gly Asp Lys Ile Thr Phe Val Asp Phe Ile Ala 
 145                150                155                160
Tyr Asp Val Leu Glu Arg Asn Gln Val Phe Glu Ala Thr Cys Leu Asp 
                 165                170                175
Ala Phe Pro Asn Leu Lys Asp Phe Ile Ala Arg Phe Glu Gly Leu Lys 
             180                185                190
Lys Ile Ser Asp Tyr Met Lys Ser Ser Arg Phe Leu Pro Arg Pro Leu 
         195                200                205
Phe Thr Lys Met Ala Ile Trp Gly Ser Lys 
     210                215



<210> 2357
<211> 1133
<212> DNA
<213> Homo sapiens
<308> NM_000848
<400> 2357

cgcagcaac  agcaccatg  ccatgacac  ggggtactg  aacatccgc  ggctggccc  60
ttccatccg  ctgctcctg  aatacacag  ctcaagcta  gaggaaaag  agtacacga  120
gggggacgc  cctgattat  acagaagcc  gtggctgaa  gaaaaattc  agctgggcc  180
ggactttcc  aatctgccc  acttgattg  tgggactca  aagatcacc  agagcaatg  240
catcctgcg  tacattgcc  gcaagcaca  cctgtgcgg  gaatcagaa  aggagcaga  300
tcgcgaaga  attttggag  accagttta  ggacagccg  atgcagctg  ccaaactct  360
ctatgaccc  gattttgag  aactgaaac  agaatacct  caggcactc  ctgaaatgc  420
gaagctcta  tcacagttt  tggggaagc  gccatggtt  cttggggac  agatcacct  480
tgtggattt  atcgcttat  atgtccttg  gagaaacca  gtatttgag  ccagctgcc  540
ggatgcctt  ccaaacctg  aggacttca  ctcccgatt  gagggcttg  agaagatct  600
tgcctacat  aagtccagc  gcttcctcc  aagacctgt  ttcacaaag  tggctgtct  660
gggcaacaa  tagggcctt  aaggcagga  gtgggagtg  ggagcccat  ctcagcctg  720
tgcccaggc  gtgcagcgc  gctggactc  gcatcccag  acctgcctc  tcgttcctt  780
ctcctgttt  ttcccatct  tactcccaa  acttcattg  ccctcttca  tccccctaa  840
cccctgtcc  atgcaggcc  tttgaagcc  cagctaccc  ctatccttc  tgaacatcc  900
ctcccatca  tacccttcc  tgcactaaa  ccagcctga  cttccttcc  gttagtggt  960
gtgtctgct  taaagggcc  gcctggccc  cgcctgtgg  gctcagccc  gagctgtcc  1020
cgtgttgca  gaaggagca  cattgactg  tttacaggc  ctgctcctg  agcatggtc  1080
ctgccttag  cctacctga  ggaagtaaa  cctcaacca  aaaaaaaaa  aaa  1133



<210> 2358
<211> 217
<212> PRT
<213> Homo sapiens
<308> P28161
<400> 2358

Pro Met Thr Leu Gly Tyr Trp Asn Ile Arg Gly Leu Ala His Ser Ile 
  1               5                  10                  15
Arg Leu Leu Leu Glu Tyr Thr Asp Ser Ser Tyr Glu Glu Lys Lys Tyr 
             20                  25                  30
Thr Met Gly Asp Ala Pro Asp Tyr Asp Arg Ser Gln Trp Leu Asn Glu 
         35                  40                  45
Lys Phe Lys Leu Gly Leu Asp Phe Pro Asn Leu Pro Tyr Leu Ile Asp 
     50                  55                  60
Gly Thr His Lys Ile Thr Gln Ser Asn Ala Ile Leu Arg Tyr Ile Ala 
 65                  70                  75                  80
Arg Lys His Asn Leu Cys Gly Glu Ser Glu Lys Glu Gln Ile Arg Glu 
                 85                  90                  95
Asp Ile Leu Glu Asn Gln Phe Met Asp Ser Arg Met Gln Leu Ala Lys 
             100                105                110
Leu Cys Tyr Asp Pro Asp Phe Glu Lys Leu Lys Pro Glu Tyr Leu Gln 
         115                120                125
Ala Leu Pro Glu Met Leu Lys Leu Tyr Ser Gln Phe Leu Gly Lys Gln 
     130                135                140
Pro Trp Phe Leu Gly Asp Lys Ile Thr Phe Val Asp Phe Ile Ala Tyr 
 145                150                155                160
Asp Val Leu Glu Arg Asn Gln Val Phe Glu Pro Ser Cys Leu Asp Ala 
                 165                170                175
Phe Pro Asn Leu Lys Asp Phe Ile Ser Arg Phe Glu Gly Leu Glu Lys 
             180                185                190
Ile Ser Ala Tyr Met Lys Ser Ser Arg Phe Leu Pro Arg Pro Val Phe 
         195                200                205
Thr Lys Met Ala Val Trp Gly Asn Lys 
     210                215



<210> 2359
<211> 487
<212> DNA
<213> Rattus norvegicus
<308> E01534
<400> 2359

tttttccca  cagccgcca  gatggccga  gtggagcag  agaaaaagc  aaccttccg  60
aagttcacc  accgtggcg  ggacctcga  cagctgctg  acatgtcct  tgagcagct  120
atgcagttg  acagcgccc  gcagagacg  cgcctgaac  gaggcctgc  gaggaagca  180
cactcactg  tcaagcgct  gaggaaggc  aagaaggag  cgccaccca  ggagaagcc  240
gaggtcgtg  agacccacc  tagggacat  atcattctg  ccgagatgg  cggcagcat  300
gtgggtgtg  acaacggca  gaccttcaa  caggtggag  tcaaacccg  gatgatcgg  360
cactacctg  gcgagttct  catcaccta  aagcctgtg  agcacggcc  gcccggcat  420
ggtgccacc  actcctccc  atttatccc  ctcaagtag  ggggacaat  aagactcgt  480
ttcagcc  487



<210> 2360
<211> 145
<212> PRT
<213> Rattus norvegicus
<308> NP_058847
<400> 2360

Met Ala Glu Val Glu Gln Lys Lys Lys Arg Thr Phe Arg Lys Phe Thr 
  1               5                  10                  15
Tyr Arg Gly Val Asp Leu Asp Gln Leu Leu Asp Met Ser Tyr Glu Gln 
             20                  25                  30
Leu Met Gln Leu Tyr Ser Ala Arg Gln Arg Arg Arg Leu Asn Arg Gly 
         35                  40                  45
Leu Arg Arg Lys Gln His Ser Leu Leu Lys Arg Leu Arg Lys Ala Lys 
     50                  55                  60
Lys Glu Ala Pro Pro Met Glu Lys Pro Glu Val Val Lys Thr His Leu 
 65                  70                  75                  80
Arg Asp Met Ile Ile Leu Pro Glu Met Val Gly Ser Met Val Gly Val 
                 85                  90                  95
Tyr Asn Gly Lys Thr Phe Asn Gln Val Glu Ile Lys Pro Glu Met Ile 
             100                105                110
Gly His Tyr Leu Gly Glu Phe Ser Ile Thr Tyr Lys Pro Val Lys His 
         115                120                125
Gly Arg Pro Gly Ile Gly Ala Thr His Ser Ser Arg Phe Ile Pro Leu 
     130                135                140
Lys 
 145



<210> 2361
<211> 515
<212> DNA
<213> Homo sapiens
<308> NM_001018
<400> 2361

ctgcgcagg  gcggaccaa  gcgatctct  ctgaggatc  ggcaagatg  cagaagtag  60
gcagaagaa  aagcggacc  tccgcaagt  cacctaccg  ggcgtggac  tcgaccagc  120
gctggacat  tcctacgag  agctgatgc  gctgtacag  gcgcgccag  ggcggcggc  180
gaaccgggg  ctgcggcgg  agcagcact  cctgctgaa  cgcctgcgc  aggccaaga  240
ggaggcgcc  cccatggag  agccggaag  ggtgaagac  cacctgcgg  acatgatca  300
cctacccga  atggtgggc  gcatggtgg  cgtctacaa  ggcaagacc  tcaaccagg  360
ggagatcaa  cccgagatg  tcggccact  cctgggcga  ttctccatc  cctacaagc  420
cgtaaagca  ggccggccc  gcatcgggg  cacccactc  tcccgcttc  tccctctca  480
gtaatggct  agctaataa  ggcgcacat  actcc  515



<210> 2362
<211> 144
<212> PRT
<213> Homo sapiens
<308> P11174
<400> 2362

Ala Glu Val Glu Gln Lys Lys Lys Arg Thr Phe Arg Lys Phe Thr Tyr 
  1               5                  10                  15
Arg Gly Val Asp Leu Asp Gln Leu Leu Asp Met Ser Tyr Glu Gln Leu 
             20                  25                  30
Met Gln Leu Tyr Ser Ala Arg Gln Arg Arg Arg Leu Asn Arg Gly Leu 
         35                  40                  45
Arg Arg Lys Gln His Ser Leu Leu Lys Arg Leu Arg Lys Ala Lys Lys 
     50                  55                  60
Glu Ala Pro Pro Met Glu Lys Pro Glu Val Val Lys Thr His Leu Arg 
 65                  70                  75                  80
Asp Met Ile Ile Leu Pro Glu Met Val Gly Ser Met Val Gly Val Tyr 
                 85                  90                  95
Asn Gly Lys Thr Phe Asn Gln Val Glu Ile Lys Pro Glu Met Ile Gly 
             100                105                110
His Tyr Leu Gly Glu Phe Ser Ile Thr Tyr Lys Pro Val Lys His Gly 
         115                120                125
Arg Pro Gly Ile Gly Ala Thr His Ser Ser Arg Phe Ile Pro Leu Lys 
     130                135                140



<210> 2363
<211> 852
<212> DNA
<213> Rattus norvegicus
<308> E03358
<400> 2363

gtaaagatg  cagaacgcg  ttacagctt  tcgctgact  cattcagcc  atctggtaa  60
cttgtgcag  ttgaatatg  tttggccgc  gtagctgga  gggcccctt  agtgggaat  120
aaagctgca  atggcgtgg  attagccac  gagaaaaag  agaaatcca  cctgtatga  180
gagaggagt  tacacaaag  ggagcccat  accaagcac  tcggtttgg  gtacagcgg  240
atgggtcca  attacagag  ccttgtaca  agagctcgg  aacttgctc  gcagtacta  300
cttgtttac  aagaaccca  tcccacagc  caactggta  agcgagtag  gtctgtgat  360
caagagtat  cccagtcag  tggtgttcg  ccatttggt  tttctttac  tatttgtgg  420
tggaatgag  gacgaccat  tttatttca  tcagatcca  ctggagctt  ctttgcctg  480
aaggccaca  caatgggaa  gaactacgt  aacgggaaa  ctttccttg  gaaaagata  540
aatgaagac  tagaactgg  agatgcgat  cacacagcc  tcttaaccc  taaggaaag  600
tttgaaggg  agatgacag  agataacat  gaagttggg  tctgcaatg  agctggctt  660
aggaggctc  ccccaactg  agtgaggga  tacttggct  ctatagcgt  atgaacatg  720
gccggaaca  tcaaggaac  ctcattcta  ttattcatt  ttaaagtat  ttttgtttg  780
gcagactta  ttctacatg  tttaatgga  tcacatttt  aaataataa  cataataaa  840
tgttaaaac  ag  852



<210> 2364
<211> 234
<212> PRT
<213> Rattus norvegicus
<308> NP_058975
<400> 2364

Met Ala Glu Arg Gly Tyr Ser Phe Ser Leu Thr Thr Phe Ser Pro Ser 
  1               5                  10                  15
Gly Lys Leu Val Gln Ile Glu Tyr Ala Leu Ala Ala Val Ala Gly Gly 
             20                  25                  30
Ala Pro Ser Val Gly Ile Lys Ala Ala Asn Gly Val Val Leu Ala Thr 
         35                  40                  45
Glu Lys Lys Gln Lys Ser Ile Leu Tyr Asp Glu Arg Ser Val His Lys 
     50                  55                  60
Val Glu Pro Ile Thr Lys His Ile Gly Leu Val Tyr Ser Gly Met Gly 
 65                  70                  75                  80
Pro Asp Tyr Arg Val Leu Val His Arg Ala Arg Lys Leu Ala Gln Gln 
                 85                  90                  95
Tyr Tyr Leu Val Tyr Gln Glu Pro Ile Pro Thr Ala Gln Leu Val Gln 
             100                105                110
Arg Val Ala Ser Val Met Gln Glu Tyr Thr Gln Ser Gly Gly Val Arg 
         115                120                125
Pro Phe Gly Val Ser Leu Leu Ile Cys Gly Trp Asn Glu Gly Arg Pro 
     130                135                140
Tyr Leu Phe Gln Ser Asp Pro Ser Gly Ala Tyr Phe Ala Trp Lys Ala 
 145                150                155                160
Thr Ala Met Gly Lys Asn Tyr Val Asn Gly Lys Thr Phe Leu Glu Lys 
                 165                170                175
Arg Tyr Asn Glu Asp Leu Glu Leu Glu Asp Ala Ile His Thr Ala Ile 
             180                185                190
Leu Thr Leu Lys Glu Ser Phe Glu Gly Gln Met Thr Glu Asp Asn Ile 
         195                200                205
Glu Val Gly Ile Cys Asn Glu Ala Gly Phe Arg Arg Leu Thr Pro Thr 
     210                215                220
Glu Val Arg Asp Tyr Leu Ala Ala Ile Ala 
 225                230



<210> 2365
<211> 866
<212> DNA
<213> Homo sapiens
<308> NM_002787
<400> 2365

atggcggag  gcgggtaca  cttttcgct  actacattc  gcccgtctg  taaacttgt  60
cagattgaa  atgctttgg  tgctgtagc  ggaggagcc  cgtccgtgg  aattaaagc  120
gcaaatggt  tggtattag  aactgagaa  aaacagaaa  ccattctgt  tgatgagcg  180
agtgtacac  aagtagaac  aattaccaa  catataggt  tggtgtaca  tggcatggg  240
cccgattac  gagtgcttg  gcacagagc  cgaaaacta  ctcaacaat  ctatcttgt  300
taccaagaa  ccattccta  agctcagct  gtacagaga  tagcttctg  gatgcaaga  360
tatactcag  caggtggtg  tcgtccatt  ggagtttct  tacttattt  tggttggaa  420
gagggacga  catatttat  tcagtcaga  ccatctgga  cttactttg  ctggaaagc  480
acagcaatg  gaaagaact  tgtgaatgg  aagactttc  ttgagaaaa  atataatga  540
gatctggaa  ttgaagatg  cattcatac  gccatctta  ccctaaagg  aagctttga  600
gggcaaatg  cagaggata  catagaagt  ggaatctgc  atgaagctg  atttaggag  660
cttactcca  ctgaagtta  ggattactt  gctgccata  cataacaat  aagtgactg  720
aaaatccag  atttcagat  atctatcta  ttaaacatg  ttaaagtat  ttttgtttt  780
cagactttt  gcatactta  ttctacatg  tttaaatcg  ctgttttta  aatgacact  840
ataaatcct  ataaactgt  aaaccc  866



<210> 2366
<211> 233
<212> PRT
<213> Homo sapiens
<308> P25787
<400> 2366

Ala Glu Arg Gly Tyr Ser Phe Ser Leu Thr Thr Phe Ser Pro Ser Gly 
  1               5                  10                  15
Lys Leu Val Gln Ile Glu Tyr Ala Leu Ala Ala Val Ala Gly Gly Ala 
             20                  25                  30
Pro Ser Val Gly Ile Lys Ala Ala Asn Gly Val Val Leu Ala Thr Glu 
         35                  40                  45
Lys Lys Gln Lys Ser Ile Leu Tyr Asp Glu Arg Ser Val His Lys Val 
     50                  55                  60
Glu Pro Ile Thr Lys His Ile Gly Leu Val Tyr Ser Gly Met Gly Pro 
 65                  70                  75                  80
Asp Tyr Arg Val Leu Val His Arg Ala Arg Lys Leu Ala Gln Gln Tyr 
                 85                  90                  95
Tyr Leu Val Tyr Gln Glu Pro Ile Pro Thr Ala Gln Leu Val Gln Arg 
             100                105                110
Val Ala Ser Val Met Gln Glu Tyr Thr Gln Ser Gly Gly Val Arg Pro 
         115                120                125
Phe Gly Val Ser Leu Leu Ile Cys Gly Trp Asn Glu Gly Arg Pro Tyr 
     130                135                140
Leu Phe Gln Ser Asp Pro Ser Gly Ala Tyr Phe Ala Trp Lys Ala Thr 
 145                150                155                160
Ala Met Gly Lys Asn Tyr Val Asn Gly Lys Thr Phe Leu Glu Lys Arg 
                 165                170                175
Tyr Asn Glu Asp Leu Glu Leu Glu Asp Ala Ile His Thr Ala Ile Leu 
             180                185                190
Thr Leu Lys Glu Ser Phe Glu Gly Gln Met Thr Glu Asp Asn Ile Glu 
         195                200                205
Val Gly Ile Cys Asn Glu Ala Gly Phe Arg Arg Leu Thr Pro Thr Glu 
     210                215                220
Val Lys Asp Tyr Leu Ala Ala Ile Ala 
 225                230



<210> 2367
<211> 852
<212> DNA
<213> Rattus norvegicus
<308> E03358
<400> 2367

gtaaagatg  cagaacgcg  ttacagctt  tcgctgact  cattcagcc  atctggtaa  60
cttgtgcag  ttgaatatg  tttggccgc  gtagctgga  gggcccctt  agtgggaat  120
aaagctgca  atggcgtgg  attagccac  gagaaaaag  agaaatcca  cctgtatga  180
gagaggagt  tacacaaag  ggagcccat  accaagcac  tcggtttgg  gtacagcgg  240
atgggtcca  attacagag  ccttgtaca  agagctcgg  aacttgctc  gcagtacta  300
cttgtttac  aagaaccca  tcccacagc  caactggta  agcgagtag  gtctgtgat  360
caagagtat  cccagtcag  tggtgttcg  ccatttggt  tttctttac  tatttgtgg  420
tggaatgag  gacgaccat  tttatttca  tcagatcca  ctggagctt  ctttgcctg  480
aaggccaca  caatgggaa  gaactacgt  aacgggaaa  ctttccttg  gaaaagata  540
aatgaagac  tagaactgg  agatgcgat  cacacagcc  tcttaaccc  taaggaaag  600
tttgaaggg  agatgacag  agataacat  gaagttggg  tctgcaatg  agctggctt  660
aggaggctc  ccccaactg  agtgaggga  tacttggct  ctatagcgt  atgaacatg  720
gccggaaca  tcaaggaac  ctcattcta  ttattcatt  ttaaagtat  ttttgtttg  780
gcagactta  ttctacatg  tttaatgga  tcacatttt  aaataataa  cataataaa  840
tgttaaaac  ag  852



<210> 2368
<211> 234
<212> PRT
<213> Rattus norvegicus
<308> NP_058975
<400> 2368

Met Ala Glu Arg Gly Tyr Ser Phe Ser Leu Thr Thr Phe Ser Pro Ser 
  1               5                  10                  15
Gly Lys Leu Val Gln Ile Glu Tyr Ala Leu Ala Ala Val Ala Gly Gly 
             20                  25                  30
Ala Pro Ser Val Gly Ile Lys Ala Ala Asn Gly Val Val Leu Ala Thr 
         35                  40                  45
Glu Lys Lys Gln Lys Ser Ile Leu Tyr Asp Glu Arg Ser Val His Lys 
     50                  55                  60
Val Glu Pro Ile Thr Lys His Ile Gly Leu Val Tyr Ser Gly Met Gly 
 65                  70                  75                  80
Pro Asp Tyr Arg Val Leu Val His Arg Ala Arg Lys Leu Ala Gln Gln 
                 85                  90                  95
Tyr Tyr Leu Val Tyr Gln Glu Pro Ile Pro Thr Ala Gln Leu Val Gln 
             100                105                110
Arg Val Ala Ser Val Met Gln Glu Tyr Thr Gln Ser Gly Gly Val Arg 
         115                120                125
Pro Phe Gly Val Ser Leu Leu Ile Cys Gly Trp Asn Glu Gly Arg Pro 
     130                135                140
Tyr Leu Phe Gln Ser Asp Pro Ser Gly Ala Tyr Phe Ala Trp Lys Ala 
 145                150                155                160
Thr Ala Met Gly Lys Asn Tyr Val Asn Gly Lys Thr Phe Leu Glu Lys 
                 165                170                175
Arg Tyr Asn Glu Asp Leu Glu Leu Glu Asp Ala Ile His Thr Ala Ile 
             180                185                190
Leu Thr Leu Lys Glu Ser Phe Glu Gly Gln Met Thr Glu Asp Asn Ile 
         195                200                205
Glu Val Gly Ile Cys Asn Glu Ala Gly Phe Arg Arg Leu Thr Pro Thr 
     210                215                220
Glu Val Arg Asp Tyr Leu Ala Ala Ile Ala 
 225                230



<210> 2369
<211> 866
<212> DNA
<213> Homo sapiens
<308> NM_002787
<400> 2369

atggcggag  gcgggtaca  cttttcgct  actacattc  gcccgtctg  taaacttgt  60
cagattgaa  atgctttgg  tgctgtagc  ggaggagcc  cgtccgtgg  aattaaagc  120
gcaaatggt  tggtattag  aactgagaa  aaacagaaa  ccattctgt  tgatgagcg  180
agtgtacac  aagtagaac  aattaccaa  catataggt  tggtgtaca  tggcatggg  240
cccgattac  gagtgcttg  gcacagagc  cgaaaacta  ctcaacaat  ctatcttgt  300
taccaagaa  ccattccta  agctcagct  gtacagaga  tagcttctg  gatgcaaga  360
tatactcag  caggtggtg  tcgtccatt  ggagtttct  tacttattt  tggttggaa  420
gagggacga  catatttat  tcagtcaga  ccatctgga  cttactttg  ctggaaagc  480
acagcaatg  gaaagaact  tgtgaatgg  aagactttc  ttgagaaaa  atataatga  540
gatctggaa  ttgaagatg  cattcatac  gccatctta  ccctaaagg  aagctttga  600
gggcaaatg  cagaggata  catagaagt  ggaatctgc  atgaagctg  atttaggag  660
cttactcca  ctgaagtta  ggattactt  gctgccata  cataacaat  aagtgactg  720
aaaatccag  atttcagat  atctatcta  ttaaacatg  ttaaagtat  ttttgtttt  780
cagactttt  gcatactta  ttctacatg  tttaaatcg  ctgttttta  aatgacact  840
ataaatcct  ataaactgt  aaaccc  866



<210> 2370
<211> 233
<212> PRT
<213> Homo sapiens
<308> P25787
<400> 2370

Ala Glu Arg Gly Tyr Ser Phe Ser Leu Thr Thr Phe Ser Pro Ser Gly 
  1               5                  10                  15
Lys Leu Val Gln Ile Glu Tyr Ala Leu Ala Ala Val Ala Gly Gly Ala 
             20                  25                  30
Pro Ser Val Gly Ile Lys Ala Ala Asn Gly Val Val Leu Ala Thr Glu 
         35                  40                  45
Lys Lys Gln Lys Ser Ile Leu Tyr Asp Glu Arg Ser Val His Lys Val 
     50                  55                  60
Glu Pro Ile Thr Lys His Ile Gly Leu Val Tyr Ser Gly Met Gly Pro 
 65                  70                  75                  80
Asp Tyr Arg Val Leu Val His Arg Ala Arg Lys Leu Ala Gln Gln Tyr 
                 85                  90                  95
Tyr Leu Val Tyr Gln Glu Pro Ile Pro Thr Ala Gln Leu Val Gln Arg 
             100                105                110
Val Ala Ser Val Met Gln Glu Tyr Thr Gln Ser Gly Gly Val Arg Pro 
         115                120                125
Phe Gly Val Ser Leu Leu Ile Cys Gly Trp Asn Glu Gly Arg Pro Tyr 
     130                135                140
Leu Phe Gln Ser Asp Pro Ser Gly Ala Tyr Phe Ala Trp Lys Ala Thr 
 145                150                155                160
Ala Met Gly Lys Asn Tyr Val Asn Gly Lys Thr Phe Leu Glu Lys Arg 
                 165                170                175
Tyr Asn Glu Asp Leu Glu Leu Glu Asp Ala Ile His Thr Ala Ile Leu 
             180                185                190
Thr Leu Lys Glu Ser Phe Glu Gly Gln Met Thr Glu Asp Asn Ile Glu 
         195                200                205
Val Gly Ile Cys Asn Glu Ala Gly Phe Arg Arg Leu Thr Pro Thr Glu 
     210                215                220
Val Lys Asp Tyr Leu Ala Ala Ile Ala 
 225                230



<210> 2371
<211> 3225
<212> DNA
<213> Rattus norvegicus
<308> E03428
<400> 2371

atggccgga  gcgcccgca  cggtctgct  ctgctgctg  tggggctgc  cgccctgca  60
agcagctgc  tggccttca  aagcccact  tctgtcttt  agaggttta  agaaactac  120
agatcattt  ccaatgaat  ccttggtac  attggacca  tcacccctc  tgatgcatc  180
gattttgcg  tggatattc  catgcctgg  gttacacct  aagagtctg  cacatactt  240
tgcatgtcc  tgcgtctgc  tgtggatga  gaagccttc  tgattgact  caagcctcg  300
gccagcatg  atactgtcc  ccatatgct  ctgtttgga  gcaatatgc  ctcgtccac  360
ggaagttac  ggttttgtg  tgaaggaac  tgtacagat  aagccaata  tctatatgc  420
tgggcaagg  atgctcccc  cacccggct  ccgaaaggt  ttggattca  agttggagg  480
gaaactgga  gcaaatact  cgtccttca  gttcactat  gcgatatca  tgcttttcg  540
gataatcac  aagactgct  tggcgtgtc  gtacatctc  cacgtgtgc  ccagccttt  600
attgcgggc  tgtacctta  gatgtctgt  gacactgtc  taccaccag  agagaaagt  660
gtgaatgct  acatttcgt  ccaatacaa  atgtatcca  tgcatgtgt  tgcctacag  720
gtccacact  accatttag  taaggtggt  agcggatac  gagtaagaa  cggacagtg  780
acactgatt  gacgccaga  cccccagct  ccacaggct  tctaccctg  ggaacaccc  840
gttgatgtt  cttttggtg  tatactggc  gccagatgt  tgttcactg  tgaagggag  900
acagaggcc  cccacatcg  cggcacttc  agtgacgaa  tgtgtaacc  gtacatcat  960
tattacatg  aagccaaat  tgcactttc  ttcatgacc  gtacaaaga  cgtggctcc  1020
gatatgttc  gaactatcc  agcagaggc  aatatccca  ttcctgtca  accggacat  1080
gttatgatg  acgggcatc  caaagaagc  gaaaacaaa  aaaagagtg  tttaatgca  1140
cagccaaaa  agggagagg  agaagtatt  gagcaggat  tccatgtgg  agaagaact  1200
gactggcct  gagtgtact  gttaccagg  caggtttct  gggtggccc  ggattctaa  1260
aataacctr  tgattttcc  cagaggtga  catgtttgg  atggaaact  ttttgacag  1320
aagtttgtt  accagcaaa  aggtcttgg  ccaattgaa  aagacacca  cctggtcat  1380
gacccaaat  atgctgaaa  cctccagtc  agtggcaag  acctgtttt  tttaccaca  1440
ggcttgagc  tagatacag  tggaaatta  tgggtcaca  atgtggctc  ccaccaggt  1500
ttcaaattg  acccgcata  caaagaagg  cctctctta  ttctgggaa  gagcatgca  1560
cctgggagt  accaaaatc  tttctgcca  cccaccgat  tggctgtgg  gcccagtac  1620
ggagctgtc  tcgtgtcag  cggttactg  aacagtcgg  ttgtgcagt  ttcaccaag  1680
ggaaagttc  tcacccagt  gggagaaga  tcctctgga  gcagtccta  gccaggcca  1740
ttcagtgtt  ctcacagtt  ggcccttgt  cctcatttg  accagttgt  tgtggcaga  1800
agggaaaat  gccgaatcc  atgcttcaa  actgacacc  aagaatttg  gagagagat  1860
aagcacgca  catttggaa  gaatgtctt  gccatttca  atataccag  tttcctctt  1920
gccgtaaac  ggaagcctt  ctttggaga  caagagccc  tgcaaggat  tgtgatgaa  1980
ttttccagt  gggaaatta  agacgtctt  aagccagta  gcaagcact  cgacatgcc  2040
catgatatt  tggcttctg  agatgggac  gtgtacatt  gagacgcac  cacaaacac  2100
gtgtggaag  tcaccctga  tgaaaaaat  gagcatcgg  cagttaaaa  ggctggcat  2160
gaagtccag  aaatcaaag  agccgaggc  gttgttgaa  ccaaagtgg  gaacaaacc  2220
acctcctca  aattgcaga  gatgcaaga  aaacagaaa  tgagcacag  gcccggctc  2280
ggagtgtcc  tggttctca  tacaaccct  ctggttatt  ctgtgctgg  cctgctggc  2340
attgtcatg  ttattcggt  gaaaaaatc  agggccttt  gaggaaagg  aagcggcgg  2400
ttaaatctg  gaaatttct  tgcaagtcg  aaaggctac  gcagaaaag  gtttgaccg  2460
gtgagcaca  aggggagtg  ccaagagaa  gatgaggac  acggaagtg  gtctgaaga  2520
gagtactcg  ccccgctgc  caagcctgc  ccttcctcc  gagctccag  cttcgcccg  2580
gtagctgga  tgaggttta  caggatgcc  agactcctt  ccctttagc  cgtgtaaag  2640
tctgtgcat  tgattgtaa  ctgtactcg  cagtgtggg  ctgtacaca  cttatttac  2700
tcatttggc  ccgttggct  ctgttttct  ggtgaggag  tccccacca  ttcactcca  2760
tgccattgt  tttatatga  cttagcgta  agaagccgc  ctcctcttc  aaggtagcg  2820
tccaacccc  gagggaagt  tagctcatt  acatttgga  acgttttag  tggtggatg  2880
aaatagccc  attctctgc  tgaacacag  attctccca  tccacaccc  tcgccagtg  2940
ctttctttg  tgcctttcc  gttcagcat  ctcagcctg  ggcagtgaa  agaaccaac  3000
tgccacacg  cgaaaagct  ctaaatctc  ttctatttt  ttaaaatca  taacattat  3060
ttgcaatga  agaaatttt  aaaagtctc  atttaaatt  tttttttaa  tttctcctc  3120
gttggtgtg  ttccgggat  tcttatttt  agatggtta  actgttaga  cactatttt  3180
cagaatctg  atgtaattt  tgtaataaa  tgttttcag  gcatt  3225



<210> 2372
<211> 976
<212> PRT
<213> Rattus norvegicus
<308> CAA42210
<400> 2372

Met Ala Gly Arg Ala Arg Ser Gly Leu Leu Leu Leu Leu Leu Gly Leu 
  1               5                  10                  15
Leu Ala Leu Gln Ser Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val 
             20                  25                  30
Phe Lys Arg Phe Lys Glu Thr Thr Arg Ser Phe Ser Asn Glu Cys Leu 
         35                  40                  45
Gly Thr Ile Gly Pro Val Thr Pro Leu Asp Ala Ser Asp Phe Ala Leu 
     50                  55                  60
Asp Ile Arg Met Pro Gly Val Thr Pro Lys Glu Ser Asp Thr Tyr Phe 
 65                  70                  75                  80
Cys Met Ser Met Arg Leu Pro Val Asp Glu Glu Ala Phe Val Ile Asp 
                 85                  90                  95
Phe Lys Pro Arg Ala Ser Met Asp Thr Val His His Met Leu Leu Phe 
             100                105                110
Gly Cys Asn Met Pro Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu 
         115                120                125
Gly Thr Cys Thr Asp Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn 
     130                135                140
Ala Pro Pro Thr Arg Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly 
 145                150                155                160
Glu Thr Gly Ser Lys Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile 
                 165                170                175
Ser Ala Phe Arg Asp Asn His Lys Asp Cys Ser Gly Val Ser Val His 
             180                185                190
Leu Thr Arg Val Pro Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met 
         195                200                205
Ser Val Asp Thr Val Ile Pro Pro Gly Glu Lys Val Val Asn Ala Asp 
     210                215                220
Ile Ser Cys Gln Tyr Lys Met Tyr Pro Met His Val Phe Ala Tyr Arg 
 225                230                235                240
Val His Thr His His Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg 
                 245                250                255
Asn Gly Gln Trp Thr Leu Ile Gly Arg Gln Asn Pro Gln Leu Pro Gln 
             260                265                270
Ala Phe Tyr Pro Val Glu His Pro Val Asp Val Thr Phe Gly Asp Ile 
         275                280                285
Leu Ala Ala Arg Cys Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr 
     290                295                300
His Ile Gly Gly Thr Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met 
 305                310                315                320
Tyr Tyr Met Glu Ala Lys Tyr Ala Leu Ser Phe Met Thr Cys Thr Lys 
                 325                330                335
Asn Val Ala Pro Asp Met Phe Arg Thr Ile Pro Ala Glu Ala Asn Ile 
             340                345                350
Pro Ile Pro Val Lys Pro Asp Met Val Met Met His Gly His His Lys 
         355                360                365
Glu Ala Glu Asn Lys Glu Lys Ser Ala Leu Met Gln Gln Pro Lys Gln 
     370                375                380
Gly Glu Glu Glu Val Leu Glu Gln Gly Asp Phe Tyr Ser Leu Leu Ser 
 385                390                395                400
Lys Leu Leu Gly Glu Arg Glu Asp Val His Val His Lys Tyr Asn Pro 
                 405                410                415
Thr Glu Lys Thr Glu Ser Gly Ser Asp Leu Val Ala Glu Ile Ala Asn 
             420                425                430
Val Val Gln Lys Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala 
         435                440                445
Glu His Glu Glu Trp Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His 
     450                455                460
Arg Phe His Gln Leu Glu Ser Thr Leu Arg Pro Ala Glu Ser Arg Ala 
 465                470                475                480
Phe Ser Phe Gln Gln Pro Gly Glu Gly Pro Trp Glu Pro Glu Pro Ser 
                 485                490                495
Gly Asp Phe His Val Glu Glu Glu Leu Asp Trp Pro Gly Val Tyr Leu 
             500                505                510
Leu Pro Gly Gln Val Ser Gly Val Ala Leu Asp Ser Lys Asn Asn Leu 
         515                520                525
Val Ile Phe His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp 
     530                535                540
Ser Lys Phe Val Tyr Gln Gln Arg Gly Leu Gly Pro Ile Glu Glu Asp 
 545                550                555                560
Thr Ile Leu Val Ile Asp Pro Asn Asn Ala Glu Ile Leu Gln Ser Ser 
                 565                570                575
Gly Lys Asn Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Thr Asp 
             580                585                590
Gly Asn Tyr Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu 
         595                600                605
Asp Pro His Ser Lys Glu Gly Pro Leu Leu Ile Leu Gly Arg Ser Met 
     610                615                620
Gln Pro Gly Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala 
 625                630                635                640
Val Glu Pro Ser Thr Gly Ala Val Phe Val Ser Asp Gly Tyr Cys Asn 
                 645                650                655
Ser Arg Ile Val Gln Phe Ser Pro Ser Gly Lys Phe Val Thr Gln Trp 
             660                665                670
Gly Glu Glu Ser Ser Gly Ser Ser Pro Arg Pro Gly Gln Phe Ser Val 
         675                680                685
Pro His Ser Leu Ala Leu Val Pro His Leu Asp Gln Leu Cys Val Ala 
     690                695                700
Asp Arg Glu Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu 
 705                710                715                720
Phe Val Arg Glu Ile Lys His Ala Ser Phe Gly Arg Asn Val Phe Ala 
                 725                730                735
Ile Ser Tyr Ile Pro Gly Phe Leu Phe Ala Val Asn Gly Lys Pro Tyr 
             740                745                750
Phe Gly Asp Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Ser 
         755                760                765
Gly Glu Ile Ile Asp Val Phe Lys Pro Val Arg Lys His Phe Asp Met 
     770                775                780
Pro His Asp Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp 
 785                790                795                800
Ala His Thr Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Met Glu 
                 805                810                815
His Arg Ser Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu 
             820                825                830
Ala Glu Ala Val Val Glu Pro Lys Val Glu Asn Lys Pro Thr Ser Ser 
         835                840                845
Glu Leu Gln Lys Met Gln Glu Lys Gln Lys Leu Ser Thr Glu Pro Gly 
     850                855                860
Ser Gly Val Ser Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val 
 865                870                875                880
Leu Val Leu Leu Ala Ile Val Met Phe Ile Arg Trp Lys Lys Ser Arg 
                 885                890                895
Ala Phe Gly Asp His Asp Arg Lys Leu Glu Ser Ser Ser Gly Arg Val 
             900                905                910
Leu Gly Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn 
         915                920                925
Phe Phe Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Val 
     930                935                940
Ser Thr Glu Gly Ser Asp Gln Glu Lys Asp Glu Asp Asp Gly Thr Glu 
 945                950                955                960
Ser Glu Glu Glu Tyr Ser Ala Pro Leu Pro Lys Pro Ala Pro Ser Ser 
                 965                970                975



<210> 2373
<211> 3744
<212> DNA
<213> Homo sapiens
<308> XM_031121
<400> 2373

gaccgagac  cctcgccgc  gccagctcg  tgctctcgc  ggcggatgg  gtgtggccg  60
cgcaggacg  ccgccgtgc  cgggccatg  agtagcggc  gctggcggc  ccgctgccc  120
accgccagc  ccagccccg  gctgcgctg  ccggtcctc  cccggcggg  tcgtatcgg  180
gtggacatg  ctggccgcg  ccctagcct  ctagttctc  ttgtttttc  aagcagctg  240
ttggctttc  gaagcccac  ttctgtctt  aagaggttt  aagaaacta  cagaccatt  300
tccaatgaa  gtcttggta  caccagacc  gtagttcct  ttgattcat  agattttgc  360
ttggatatt  gcatgcctg  ggttacacc  aaacagtcc  atacatact  ctgcatgtc  420
atgcgaata  cagtggatg  ggaagcctt  gtgattgac  tcaagcctc  agccagcat  480
gatactgtc  atcacatgt  actttttgg  tgcaatatg  cttcatcca  tggaagtta  540
tggttttgt  atgaaggaa  ctgtacaga  aaagccaat  ttctgtatg  ctgggcgag  600
aatgctccc  ctacccggc  ccccaaagg  gttggattc  gagttggag  agagactgg  660
agtaaatac  ttgtactac  ggtacacta  ggggatatt  gtgctttta  agataataa  720
aaggactgt  ctggtgtgt  cttacacct  acacgtctg  cacagcctt  aattgctgg  780
atgtacctt  tgatgtctg  tgacactgt  atcccagca  gagaaaaag  ggtgaattc  840
gacatttca  gccattata  aaattatcc  atgcatgtc  ttgcctata  agttcacac  900
caccattta  gtaaggtag  aagtggata  agagtaaga  atggacagt  gacactgat  960
ggacggcag  gccctcagc  gccacaggc  ttctaccct  tggggcatc  agttgatgt  1020
agttttggt  acctactgg  tgcaagatg  gtattcact  gtgaaggaa  gacagaagc  1080
acacacatt  gtggcacgt  tagtgatga  atgtgcaac  tatacatta  gtattacat  1140
gaagccaag  atgcagttt  tttcatgac  tgtacccag  atgtagctc  agatatgtt  1200
agaaccata  caccagagg  caacattcc  attcccgtg  agtctgata  ggttatgat  1260
catgaacat  ataaagaaa  agaatataa  gataagatt  ctttactac  gcagccaaa  1320
cgagaagaa  aagaagtgt  agaccaggg  gatttctat  cactacttt  caagctgct  1380
ggagaaagg  aagatgttg  tcatgtgca  aaatataat  ctacagaaa  ggcagaatc  1440
gagtcagac  tggtagctg  gattgcaaa  gtagtccaa  aaaaggatc  tggtcgatc  1500
gatgccaga  agggtgcag  acatgagag  ggtaatgct  ttcttgtca  agacagaat  1560
cacaaattc  acagactag  atctacctt  aggccacca  agagcagag  tttctcatt  1620
cagcagccc  cacctggtg  aggcacctg  gaaccagaa  acacaggag  tttccacat  1680
gaagaggca  tggattggc  tggagtata  ttgttacca  gccaggttt  tggggtggc  1740
ctagaccct  agaataacc  ggtgatttt  cacagaggt  accatgtct  ggatggaaa  1800
tcgtttgac  gcaagtttg  ttaccagca  ataggactc  gaccaattg  agaagacac  1860
attcttgtc  tagatccaa  taatgctgc  gtactccag  ccagtggaa  aaatctgtt  1920
tacttgcca  atggcttga  tatagataa  gatgggaat  attgggtca  agacgtggc  1980
ctccatcag  tgttcaaac  ggatccaaa  aataaagaa  gccctgtat  aatcctggg  2040
aggagcatg  aaccaggca  tgaccagaa  cacttctgt  aacccactg  tgtggctgt  2100
gatccaggc  ctggagcca  ttatgtatc  gatggttac  gcaacagca  gattgtgca  2160
ttttcacca  gtggaaagt  catcacaca  tggggagaa  agtcttcag  gagcagtcc  2220
ctgccaggc  agttcactg  tcctcacag  ttggctctt  tgcctcttt  gggccaatt  2280
tgtgtggca  accgggaaa  tggtcggat  cagtgtttt  aaactgaca  caaagaatt  2340
gtgagagag  ttaagcatt  atcatttgg  agaaatgta  ttgcaattt  atatatacc  2400
ggcttgctc  ttgcagtga  tgggaagcc  cattttggg  accaagaac  tgtacaagg  2460
tttgtgatg  acttttcca  tggggaaat  atagacatc  tcaagccag  gcgcaagca  2520
tttgatatg  ctcatgata  tgttgcatc  gaagatggg  ctgtgtaca  tggagatgc  2580
cataccaac  ccgtgtgga  gttcacctt  actgagaaa  tggaacatc  atcagttaa  2640
aaggctggc  ttgaggtcc  ggaaatcaa  gaagccgag  cagttgttg  aaccaaaat  2700
gagaacaaa  ccacctcct  agaattgca  aagatgcaa  agaaacaga  actgatcaa  2760
gagccaggc  cgggagtgc  tgttgttct  attacaacc  ttctggtta  tccggtggt  2820
gtcctgctg  ccattgcca  atttattcg  tggaaaaaa  caagggcct  tggagcaga  2880
tctgaacac  aactcgaga  gagttcagg  agagtactg  gaagattta  aggaaaggg  2940
agtggaggc  taaaccttg  taatttctt  gcaagccgt  agggctaca  tcgaaaagg  3000
tttgaccgg  ttagcactg  gggcagtga  caagagaaa  aggatgatg  aagtgaatc  3060
gaagaggag  attcagcac  tctgcctgc  ctcgcacct  cctcctcct  aaaaccaag  3120
tttgattta  attgagtaa  atttaccca  aatgtcaga  tcctttccc  ttagcacgt  3180
taaagttct  tgtatttaa  tgtaaactg  actagtctg  gtgggactg  acacacttt  3240
tttacttcg  tttggttaa  ttggcttct  tttctagtt  aggagtttc  taaaagttc  3300
taacagtgc  attgtcttt  tatgaacat  gactagaga  accgtcctc  ttttccatc  3360
taattctaa  ctaacaatg  aagatttgc  catttacac  tttgagact  tttggtgga  3420
gtaaataac  ccattcttt  cttgaacac  gtattttcc  aatagcact  tcattgcca  3480
tgtctttct  tggtgcctt  cctgttcag  attcttagc  tgtggcagt  aagagaaac  3540
ttgtgctac  tgacgacaa  gctgctaaa  ctcctattt  tttaaaatc  ctaacatta  3600
attgcaatg  aggaaataa  aaagtctct  tttaaattc  tttttaaat  ttcttcagt  3660
ggtgtgttt  tgggatgtc  tatttttag  tggttacac  gttagaaca  tattttcag  3720
atctgaatg  aatttgtgt  ataa  3744



<210> 2374
<211> 974
<212> PRT
<213> Homo sapiens
<308> XP_031121
<400> 2374

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
  1               5                  10                  15
Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
             20                  25                  30
Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
         35                  40                  45
Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
     50                  55                  60
Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
 65                  70                  75                  80
Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                 85                  90                  95
Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
             100                105                110
Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
         115                120                125
Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
     130                135                140
Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
 145                150                155                160
Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                 165                170                175
Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
             180                185                190
Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
         195                200                205
Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
     210                215                220
Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
 225                230                235                240
Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                 245                250                255
Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
             260                265                270
Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
         275                280                285
Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
     290                295                300
Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
 305                310                315                320
Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                 325                330                335
Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
             340                345                350
Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
         355                360                365
Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
     370                375                380
Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
 385                390                395                400
Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                 405                410                415
Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
             420                425                430
Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
         435                440                445
Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
     450                455                460
Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
 465                470                475                480
Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                 485                490                495
His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
             500                505                510
Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
         515                520                525
His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
     530                535                540
Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
 545                550                555                560
Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                 565                570                575
Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
             580                585                590
Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
         595                600                605
Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
     610                615                620
Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
 625                630                635                640
Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                 645                650                655
Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
             660                665                670
Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
         675                680                685
Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
     690                695                700
Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
 705                710                715                720
Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                 725                730                735
Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
             740                745                750
Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
         755                760                765
Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
     770                775                780
Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
 785                790                795                800
Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                 805                810                815
Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala 
             820                825                830
Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln 
         835                840                845
Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val 
     850                855                860
Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu 
 865                870                875                880
Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly 
                 885                890                895
Ala Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly 
             900                905                910
Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe 
         915                920                925
Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr 
     930                935                940
Glu Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu 
 945                950                955                960
Glu Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                 965                970



<210> 2375
<211> 1218
<212> DNA
<213> Rattus norvegicus
<308> E06822
<400> 2375

gactcttct  gggaagagc  gcatctgag  atgaattcc  aaattcaga  gatggagtt  60
aacgatggt  actccatcc  tgtactggg  tttggcacc  atgcaaccg  agagaatct  120
agaaaaaag  ctatggagt  cacgaaaat  gctatagat  ttgggttcc  ccatattga  180
tgttctcac  tgtaccaga  tgaagaaga  ataggtcag  ccattgtaa  caagattga  240
gatggcact  tgaaaaggg  agatatatt  tatacttca  agctttggt  aacttccca  300
cgtccagag  tggtcagac  cagcttgga  aattcactg  ggaaactta  tttggacta  360
gtagacctc  atctcattc  tttcccggt  tctctgaag  caggggatg  gcttttacc  420
caagatgag  atggaaact  aatacttga  acagtggat  tctgcgaca  ctgggaggc  480
atggagaag  gtaaggatg  aggattggc  aagtccatc  gggtgtcca  ctttaaccg  540
aggcagctg  agaagatcc  gaataagcc  gggctcaag  acaggcctg  gtgcaacca  600
gtagaatgc  atctttatc  caaccagag  aagctgctc  cttactgca  gatgaatga  660
atcgttctg  ttgcctatg  tgccctggg  actcagaga  acaaatact  tattaatga  720
gatacccca  ttctcttgg  tgatcccat  ctttgtacc  tggcaaaga  gtacaagcg  780
actccagcc  tgattgccc  tcgctacca  ctggagcgt  ggattgtga  cctagtcaa  840
agtttcaat  aggagagaa  cagagagaa  ctgcaggtc  ttgatttcc  gttggcttc  900
gatgacatg  aaattttag  taacctgga  agaaatctt  ggtactttc  tgctaatat  960
tttaaggct  accctaact  tccattctc  gatgaatac  aagatggca  ccctagcca  1020
gagttctgc  cgaagctcc  ttgtgtgat  ctggactct  agaggccaa  aatacaaca  1080
actgactcc  atccatact  cttagcaac  cacccccca  tttgagctg  gtctgtaca  1140
cggggagca  attcactaa  ttttcctgc  tttctgtaa  taaataaaa  tattttgct  1200
cagcctcaa  aaaaaaaa  1218



<210> 2376
<211> 323
<212> PRT
<213> Rattus norvegicus
<308> BAA03317
<400> 2376

Met Asn Ser Lys Ile Gln Lys Met Glu Leu Asn Asp Gly His Ser Ile 
  1               5                  10                  15
Pro Val Leu Gly Phe Gly Thr Tyr Ala Thr Glu Glu Asn Leu Arg Lys 
             20                  25                  30
Lys Ser Met Glu Ser Thr Lys Ile Ala Ile Asp Val Gly Phe Arg His 
         35                  40                  45
Ile Asp Cys Ser His Leu Tyr Gln Asn Glu Glu Glu Ile Gly Gln Ala 
     50                  55                  60
Ile Val Ser Lys Ile Glu Asp Gly Thr Val Lys Arg Glu Asp Ile Phe 
 65                  70                  75                  80
Tyr Thr Ser Lys Leu Trp Ser Thr Ser His Arg Pro Glu Leu Val Arg 
                 85                  90                  95
Pro Ser Leu Glu Asn Ser Leu Arg Lys Leu Asn Leu Asp Tyr Val Asp 
             100                105                110
Leu Tyr Leu Ile His Phe Pro Val Ser Leu Lys Pro Gly Asp Glu Leu 
         115                120                125
Leu Pro Gln Asp Glu His Gly Asn Leu Ile Leu Asp Thr Val Asp Leu 
     130                135                140
Cys Asp Thr Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
 145                150                155                160
Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Lys Ile 
                 165                170                175
Leu Asn Lys Pro Gly Leu Lys His Arg Pro Val Cys Asn Gln Val Glu 
             180                185                190
Cys His Leu Tyr Leu Asn Gln Ser Lys Leu Leu Ala Tyr Cys Lys Met 
         195                200                205
Asn Asp Ile Val Leu Val Ala Tyr Gly Ala Leu Gly Thr Gln Arg Tyr 
     210                215                220
Lys Tyr Cys Ile Asn Glu Asp Thr Pro Val Leu Leu Asp Asp Pro Ile 
 225                230                235                240
Leu Cys Thr Met Ala Lys Lys Tyr Lys Arg Thr Pro Ala Leu Ile Ala 
                 245                250                255
Leu Arg Tyr Gln Leu Glu Arg Gly Ile Val Thr Leu Val Lys Ser Phe 
             260                265                270
Asn Glu Glu Arg Ile Arg Glu Asn Leu Gln Val Phe Asp Phe Gln Leu 
         275                280                285
Ala Ser Asp Asp Met Glu Ile Leu Asp Asn Leu Asp Arg Asn Leu Arg 
     290                295                300
Tyr Phe Pro Ala Asn Met Phe Lys Ala His Pro Asn Phe Pro Phe Ser 
 305                310                315                320
Asp Glu Tyr 
                 325



<210> 2377
<211> 1204
<212> DNA
<213> Homo sapiens
<308> NM_003739
<400> 2377

ctctgagga  aagcagcag  aaacatttg  tagtcagac  agtgacagg  aatggattc  60
aaacagcag  gtgtaaagc  aaatgatgg  cacttcatg  ctgtattgg  atttggcac  120
tatgcacct  cagaggttc  gagaagtaa  gctttggag  tcacaaaat  agcaataga  180
gctgggttc  gccatatag  ttctgctca  ttatacaat  atgaggagc  ggttggact  240
gccatccga  gcaagattg  agatggcag  gtgaagaga  aagacatat  ctacacttc  300
aagctttgg  ccacttttc  tcgaccaga  ttggtccga  cagccttgg  aaactcact  360
aaaaaagct  aattggact  tgttgacct  tatcttatt  attctccaa  gtctctaaa  420
ccaggtgag  aactttcac  aacagatga  aatggaaaa  taatatttg  catagtgga  480
ctctgtacc  cctgggagg  catggagaa  tgtaaggat  caggattgg  caagtccat  540
ggggtgtca  acttcaacc  caggcagct  gagatgatc  tcaacaagc  aggactcaa  600
tacaagcct  tctgcaacc  ggtagaatg  catccgtat  tcaaccgga  taaattgct  660
gatttctgc  agtcgaaag  tattgttct  gttgcctat  gtgctctgg  atctcaacg  720
gacaaacga  gggtggacc  gaactcccc  gtgctcttg  aggacccag  cctttgtgc  780
ttggcaaaa  agcacaagc  aaccccagc  ctgattgcc  tgcgctacc  gctgcagcg  840
ggggttgtg  tcctggcca  gagctacaa  gagcagcgc  tcagacaga  cgtgcaggt  900
tttgagttc  agttgactg  agaggacat  aaagccata  atggcctag  cagaaatct  960
cactatttt  acagtgata  ttttgctag  caccctaat  atccatatt  agatgaata  1020
taacatgga  agctttgcc  gatgtctac  agaagccct  tgtgtggat  gtgacgcag  1080
ggacgtctc  atgccggtg  ctggacata  cacctctac  taaatccgt  ctgtttagc  1140
acttcagtc  actacagct  agtccatag  ccagaaaga  aataaattt  tatcatttt  1200
aaat  1204



<210> 2378
<211> 323
<212> PRT
<213> Homo sapiens
<308> P42330
<400> 2378

Met Asp Ser Lys Gln Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
  1               5                  10                  15
Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Pro Glu Val Pro Arg Ser 
             20                  25                  30
Lys Ala Leu Glu Val Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
         35                  40                  45
Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
     50                  55                  60
Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
 65                  70                  75                  80
Tyr Thr Ser Lys Leu Trp Ser Thr Phe His Arg Pro Glu Leu Val Arg 
                 85                  90                  95
Pro Ala Leu Glu Asn Ser Leu Lys Lys Ala Gln Leu Asp Tyr Val Asp 
             100                105                110
Leu Tyr Leu Ile His Ser Pro Met Ser Leu Lys Pro Gly Glu Glu Leu 
         115                120                125
Ser Pro Thr Asp Glu Asn Gly Lys Val Ile Phe Asp Ile Val Asp Leu 
     130                135                140
Cys Thr Thr Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
 145                150                155                160
Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile 
                 165                170                175
Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
             180                185                190
Cys His Pro Tyr Phe Asn Arg Ser Lys Leu Leu Asp Phe Cys Lys Ser 
         195                200                205
Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser Gln Arg Asp 
     210                215                220
Lys Arg Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
 225                230                235                240
Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 
                 245                250                255
Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
             260                265                270
Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
         275                280                285
Thr Ala Glu Asp Met Lys Ala Ile Asp Gly Leu Asp Arg Asn Leu His 
     290                295                300
Tyr Phe Asn Ser Asp Ser Phe Ala Ser His Pro Asn Tyr Pro Tyr Ser 
 305                310                315                320
Asp Glu Tyr 
                 325



<210> 2379
<211> 1733
<212> DNA
<213> Rattus norvegicus
<308> E12625
<400> 2379

ggccgctgc  cctgcccgg  cttgcgccg  gaccgctgt  aatcgcggg  caccaggaa  60
aaaaggccc  ttgcagaga  ttgaaaatg  ccatgaaca  aagtgttgg  ctcttcagc  120
ccgcatccc  ggctgtgga  tacgtagat  ccctgctgc  tgagaatcc  ctgcaggaa  180
cctttaaga  tgcttgggt  tacatgttg  acaactata  aaagttcca  atcgcaacc  240
ggggctccc  gatcgttca  gagacgatc  atttcctgt  ctctttacc  ggctttcta  300
tccagttta  acctttcat  agaaagtac  agattcaaa  ggataaacc  gaaaccttt  360
aaggccagt  gaagtgttt  aaaggaatt  tgtttaatc  tttttttat  cagttgcct  420
tgatttgtg  aacatacta  tttacagag  ttttcaata  tccttatga  tgggaaaga  480
tgccaagat  gtatttcac  ttggcaagg  gtttgggct  tgcagtcat  gaggatacc  540
ggcactatt  cctgcacag  ctccttcac  acaagagga  ttataaata  attcataaa  600
tccatcacg  gttccaggc  ccatttgga  tcgaagcag  atatgcaca  cccttggaa  660
ccctaattc  tgggactgg  tttttcatt  gaattgtgc  tttgtgtga  catgtaatt  720
ttctgtggg  atgggtgac  atgcgtttg  tagaaacca  cgatgtgca  agtggttat  780
atatccctc  caacccgtt  aactacatc  ctttttata  cggggctcg  catcacgat  840
tccaccaca  gaacttcat  gggaattac  cctccacct  cacgtggtg  gacagaatc  900
ttgggacgg  tgtccagta  catgcctac  ctgaaaaga  gaagaagct  gggaaaaag  960
ctgagtgag  acctgctct  cgccctcct  actgcagct  gcaactaac  ttgcttctg  1020
ggagcagaa  taagcacgt  actcggctg  tggtgatag  aacattaac  acctttaag  1080
actctgcgg  atgagaact  ttctgctcg  cacccaaga  ctgtaaatg  gggaacaaa  1140
aaatagata  ataagtaca  ttttcagga  gaggtttta  aggccatat  gccaacctc  1200
ccgaaaggt  tcaggaacc  gaggaagtg  taatgtaca  ctcaccact  cacgccacc  1260
gaggctgaa  ttgacgttg  cttttaagc  tttttacat  cactggcca  ttcagaaaa  1320
tctcaacaa  aatgtctgc  ttcgagttt  agtcatggt  ttttttaga  ttgacttga  1380
atgaaaata  cacaaagtg  atatatcag  tggtgatcg  gtgactgaa  cccccctgg  1440
ctgcggttg  ccagttcag  actattctt  ctgtgaagg  ttgtttgat  gtagtatct  1500
tatcagcat  ttgtaaatt  gctcatttc  tacgtgatg  acatagaat  ctataactt  1560
acgactttc  agttacttg  ggcattttt  aattgagga  ccccacttc  gatgtccac  1620
cccttgtct  tgtgtgtca  gtggtctcg  agctttgtg  attctctat  tgcacctgt  1680
agagctggt  aaataaatg  gatttttgt  cgaaaaaaa  aaaaaaaaa  aaa  1733



<210> 2380
<211> 293
<212> PRT
<213> Rattus norvegicus
<308> BAA23329
<400> 2380

Met Ala Met Asn Lys Ser Val Gly Leu Phe Ser Ser Ala Ser Leu Ala 
  1               5                  10                  15
Val Asp Tyr Val Asp Ser Leu Leu Pro Glu Asn Pro Leu Gln Glu Pro 
             20                  25                  30
Phe Lys Asn Ala Trp Val Tyr Met Leu Asp Asn Tyr Thr Lys Phe Gln 
         35                  40                  45
Ile Ala Thr Trp Gly Ser Leu Ile Val His Glu Thr Ile Tyr Phe Leu 
     50                  55                  60
Phe Ser Leu Pro Gly Phe Leu Phe Gln Phe Ile Pro Phe Met Arg Lys 
 65                  70                  75                  80
Tyr Lys Ile Gln Lys Asp Lys Pro Glu Thr Phe Glu Gly Gln Trp Lys 
                 85                  90                  95
Cys Leu Lys Gly Ile Leu Phe Asn His Phe Phe Ile Gln Leu Pro Leu 
             100                105                110
Ile Cys Gly Thr Tyr Tyr Phe Thr Glu Phe Phe Asn Ile Pro Tyr Asp 
         115                120                125
Trp Glu Arg Met Pro Arg Trp Tyr Phe Thr Leu Ala Arg Cys Leu Gly 
     130                135                140
Cys Ala Val Ile Glu Asp Thr Trp His Tyr Phe Leu His Arg Leu Leu 
 145                150                155                160
His His Lys Arg Ile Tyr Lys Tyr Ile His Lys Val His His Glu Phe 
                 165                170                175
Gln Ala Pro Phe Gly Ile Glu Ala Glu Tyr Ala His Pro Leu Glu Thr 
             180                185                190
Leu Ile Leu Gly Thr Gly Phe Phe Ile Gly Ile Val Leu Leu Cys Asp 
         195                200                205
His Val Ile Leu Leu Trp Ala Trp Val Thr Met Arg Leu Leu Glu Thr 
     210                215                220
Ile Asp Val His Ser Gly Tyr Asp Ile Pro Leu Asn Pro Leu Asn Tyr 
 225                230                235                240
Ile Pro Phe Tyr Thr Gly Ala Arg His His Asp Phe His His Met Asn 
                 245                250                255
Phe Ile Gly Asn Tyr Ala Ser Thr Phe Thr Trp Trp Asp Arg Ile Phe 
             260                265                270
Gly Thr Asp Val Gln Tyr His Ala Tyr Thr Glu Lys Met Lys Lys Leu 
         275                280                285
Gly Lys Lys Ser Glu 
     290



<210> 2381
<211> 1741
<212> DNA
<213> Homo sapiens
<308> NM_006745
<400> 2381

ttggaacac  tggcgagtc  tcggtgtcg  tggccggca  tcatctcgc  gccgttcag  60
attataagg  tgtctgcag  gatttgaaa  atggcaaca  atgaaagtg  cagcatctt  120
agttcagca  ccttggctg  ggaatatgt  gattcactt  tacctgaga  tcctctgca  180
gaaccattt  aaaatgctt  gaactatat  ttgaataat  atacaaagt  ccagattgc  240
acatgggga  cccttatag  tcatgaagc  ctttatttc  tattctgtt  acctggatt  300
ttatttcaa  ttatacctt  tatgaaaaa  tacaaaatt  aaaaggata  gccagagac  360
tgggaaaac  aatggaagt  tttcaaagt  cttctcttt  atcacttct  tatccagct  420
cctttgatt  gtggaacct  ttattttac  gagtatttc  atattcctt  tgattggga  480
agaatgcca  gatggtatt  tcttttggc  agatgcttt  gttgtgcag  cattgaaga  540
acttggcac  attttctgc  tagactctt  caccacaaa  gaatataca  gtatattca  600
aaagttcat  atgagtttc  ggctccatt  ggaatggaa  ctgaatatg  acatccttt  660
gagactcta  ttcttggaa  tggattttt  attggaatc  tgcttttgt  tgatcatgt  720
attcttctt  gggcatggg  gaccattcg  ttattagaa  ctattgatg  ccatagtgg  780
tatgatatt  ctctcaacc  tttaaatct  atccctttc  atgctggtt  tcggcatca  840
gatttccac  acatgaact  cattggaaa  tatgcttca  catttacat  gtgggatcg  900
atttttgga  cagactctc  gtataatgc  tataatgaa  agaggaaga  gtttgagaa  960
aagactgaa  aaatatctc  cgtaaacct  cctgaaaga  aaacgtttt  ctgaattca  1020
aaactagta  ctaacattg  ttctggaga  cagaaataa  catgtcttc  ggctactaa  1080
tgataaaaa  aacattaac  acctttaat  accttccta  tgggaactt  ttctacttt  1140
cctacaagt  ctatatatg  agaaatgaa  aaatatata  ttaagtaca  ttttcatga  1200
gaagtttta  aagaccatg  tcctaagct  ccaagaagg  tttggatac  agaagtatt  1260
atctatggc  tttctccca  taaaaccat  ggcctgaag  tcacattgg  tctttaaat  1320
ttttagata  atactggtc  tttcagaaa  ttcttcata  tggtattgg  cttatattt  1380
acttttttt  tattttttt  ttgagacaa  gccacactc  gtctccttg  ctggagtgt  1440
gtggcacag  ctcagctca  tgcaacctc  gcctcccag  tcaagcaat  cttctgcct  1500
agcctccca  gtagctggg  ttacaggca  ccgccacca  gcccagcta  tttttgtat  1560
tttgtagag  tggggtttc  cgatgttgg  caggctggt  tcaaacttc  gacctcaag  1620
gatctgccc  ccttggcct  ccaaagtgc  gggattaca  gtgtaagcc  ctgcgcccg  1680
cctttttaa  tttaaacat  ttttagaat  cacctaaag  tcaaaatat  atggattga  1740
c  1741



<210> 2382
<211> 293
<212> PRT
<213> Homo sapiens
<308> Q15800
<400> 2382

Met Ala Thr Asn Glu Ser Val Ser Ile Phe Ser Ser Ala Ser Leu Ala 
  1               5                  10                  15
Val Glu Tyr Val Asp Ser Leu Leu Pro Glu Asn Pro Leu Gln Glu Pro 
             20                  25                  30
Phe Lys Asn Ala Trp Asn Tyr Met Leu Asn Asn Tyr Thr Lys Phe Gln 
         35                  40                  45
Ile Ala Thr Trp Gly Ser Leu Ile Val His Glu Ala Leu Tyr Phe Leu 
     50                  55                  60
Phe Cys Leu Pro Gly Phe Leu Phe Gln Phe Ile Pro Tyr Met Lys Lys 
 65                  70                  75                  80
Tyr Lys Ile Gln Lys Asp Lys Pro Glu Thr Trp Glu Asn Gln Trp Lys 
                 85                  90                  95
Cys Phe Lys Val Leu Leu Phe Asn His Phe Cys Ile Gln Leu Pro Leu 
             100                105                110
Ile Cys Gly Thr Tyr Tyr Phe Thr Glu Tyr Phe Asn Ile Pro Tyr Asp 
         115                120                125
Trp Glu Arg Met Pro Arg Trp Tyr Phe Leu Leu Ala Arg Cys Phe Gly 
     130                135                140
Cys Ala Val Ile Glu Asp Thr Trp His Tyr Phe Leu His Arg Leu Leu 
 145                150                155                160
His His Lys Arg Ile Tyr Lys Tyr Ile His Lys Val His His Glu Phe 
                 165                170                175
Gln Ala Pro Phe Gly Met Glu Ala Glu Tyr Ala His Pro Leu Glu Thr 
             180                185                190
Leu Ile Leu Gly Thr Gly Phe Phe Ile Gly Ile Val Leu Leu Cys Asp 
         195                200                205
His Val Ile Leu Leu Trp Ala Trp Val Thr Ile Arg Leu Leu Glu Thr 
     210                215                220
Ile Asp Val His Ser Gly Tyr Asp Ile Pro Leu Asn Pro Leu Asn Leu 
 225                230                235                240
Ile Pro Phe Tyr Ala Gly Ser Arg His His Asp Phe His His Met Asn 
                 245                250                255
Phe Ile Gly Asn Tyr Ala Ser Thr Phe Thr Trp Trp Asp Arg Ile Phe 
             260                265                270
Gly Thr Asp Ser Gln Tyr Asn Ala Tyr Asn Glu Lys Arg Lys Lys Phe 
         275                280                285
Glu Lys Lys Thr Glu 
     290



<210> 2383
<211> 4396
<212> DNA
<213> Rattus norvegicus
<308> E12829
<400> 2383

tctggcctc  tgccctaag  agcgagtgc  gagggagtg  gagcgagac  gcccgaacg  60
aagtgtctg  cttcccggc  aggcccagg  gtccgtccc  ccgcccatg  actcgttgc  120
ccgcgagca  cgccgtcgt  aggccgtcc  cgtcactct  gctcgcccc  atccccggg  180
agccattcc  ccctaccca  gtctggccg  ggactggac  tcgtgtcga  gcgccttcc  240
cagtccgcg  cgcgctgcg  ccctggaag  gggcgccgc  gccaacgag  ggaggagcc  300
cggccgcgg  gcccagcag  cactgagcc  gcaggcggg  tcgaggccg  caacatggc  360
agcgcttcg  accacatct  caacttgct  gaaaaaatg  catccagcg  caaggactt  420
aggtttatg  ctacaaatg  tctgatgac  gaactgcag  aagactcca  caagctgga  480
gatgacagc  aaaggaaag  cgtaaagat  attctgaag  tgctggagg  taaaaatgg  540
gaagtgcag  acttagctg  gaaatgtct  ggtccttta  tgagtaaag  gaaagagta  600
caagttgag  cgattgtag  caccctctg  acaaacatg  tttctgaca  ggagcagct  660
cgagatatt  ccagtattg  ccttaaaac  gtaattgga  aactccctc  agcttccag  720
ggctctgca  tagctgcta  tgtatgtaa  aagattact  gacgcctta  cagtgcaat  780
gcaaagcag  aagatgttt  tgttcagct  gaagcttta  atattatgg  tgatatgtt  840
agcaggcaa  gaggactgc  tgttaattt  catccttca  ttctgacct  tctacttcc  900
cagctgact  gccctagac  tgcagtcag  aaaagaaca  ttattgctc  tggccacct  960
gttatgagc  gcggaaaca  agtttttgt  gaccttatt  aacatctgt  gtcagagtt  1020
tccaaaaat  actccatgt  aacaacaag  acctacata  agtgtattg  tgctattag  1080
aggcaagct  gccatagaa  aggtgaata  cttgaaaag  taattcctt  ggtggtaaa  1140
ttttgtaat  tagatgatg  tgaattaag  gaatactgc  ttcaagctt  tgaatcatt  1200
gtgagaaga  gccctaagg  agtttatcc  catgtttct  ccattataa  catttgtct  1260
aaatacctt  cctatgatc  aaattacaa  tatgatgat  aagatgaag  tgagaatgc  1320
atggatgct  atggcggag  tgacgatga  caagggagt  acgatgaat  cagtgatga  1380
gatgacatg  gttggaaag  gaggcgtgc  gctgccaag  gcctggatg  cgtagttag  1440
acacggcat  agatgctcc  ggaattcta  aagaccgtc  ctcctgcac  gatatccag  1500
tttaaagag  gcgaagaga  tgtaaaggc  gatgttttt  atgcatacc  ttctctttt  1560
aagcaaact  gtccagtac  aagttggct  tgcgaccct  atgcaatgg  gcaaggaga  1620
acaccctta  caatgcttc  gagtcaggt  cccaacatt  ttaaagccc  acataaaca  1680
atgaaagaa  aaagtgtaa  gacccgaca  tgttgtttt  acatgttaa  tgaactggt  1740
aatgtgttg  ctggggcac  aacccaaca  attcctgta  ttgtaccag  aatcatttt  1800
tcactcaat  ataagtcca  ctcatcgaa  ctgaagatt  atgcattgt  ctgtctgta  1860
gtgatcctc  gtaaccact  tccgcaagt  ttccacccg  atgttcagg  tttggtccc  1920
ccagtggtg  cttgtgttg  tgacccatt  tacaagatc  catcagaag  ccttcttgt  1980
actcagcag  ttgtcaaag  aatccgtcc  ctggaccaa  cctcctcct  cgatgcaac  2040
ccttacatc  aagatctct  cacttgtac  attaagcgc  taaaagcag  tgacattga  2100
caggaagtc  aggagaggg  tatttcctg  atgggacag  ttatttgca  tcttggaga  2160
aatttgggc  ctgacttat  aaatacact  cagattttc  tggagagac  caagaatga  2220
atcacccgg  taacgacag  gaaagcact  accctgatt  ctgggtcac  tttgaagat  2280
gatctgagg  ctgtgctgg  agagggagt  cctatcctt  cttcatttc  caggaaaaa  2340
cagagagct  tgaaactgg  gaccctctc  gccctagat  ttctcatta  aaactatag  2400
gacagtttg  cggccgcca  gattgatgc  gttctggat  agctccctc  tcttatcag  2460
gaaagtgat  tgcacgtgt  ccagatggc  atcagcttc  ttactaccc  ggcaaaagt  2520
tatccctcc  ccctttcaa  gataagcgg  tctattctc  atgaactga  tggacttgt  2580
aggtcacct  tgctgcagg  aggagctct  agtgccatg  tagacttct  ccaagcttt  2640
gttgtcact  gaacaaaca  tctaggata  atggatttg  tgcgcatgc  aacgggtcc  2700
gtttactct  agagcacag  tcttactca  aagcagtct  actattcca  tgccaaatg  2760
gtagctgcc  ttactcgag  atgccctaa  gagggaccg  ctgtagtag  tcagtttat  2820
caagatgtc  agaactcca  gtctacaga  tccattcgt  tcttagcgc  cctttctct  2880
ggagaagtt  gacaccata  tgacttaag  gggcagttg  agctaaaat  tgtaatatt  2940
gaggctttc  cctctccta  tgaagaagt  aaatcagct  catcctatg  gttaggcag  3000
atcagtgta  gcaacctcc  tgagtatct  ccatttgta  tacaagaaa  aaccagtca  3060
cccaaaagg  agtacctgc  gctgcattc  ctgaaggaa  tcattagct  tgcgtcagt  3120
gtcggcctt  agccgtatg  cgagaacat  tgggccttg  tgctaaagc  ctgtgagtg  3180
gcggaggag  gcaccagaa  cgtcgtcgc  gagtgtcta  ggaagctca  tcttattga  3240
cctgaaact  tcctcccga  gcttaaagg  tatttgata  cagggtcat  ctatgccag  3300
agctcagtg  ttacagctg  gaagttcac  atttctgac  accctcagc  cattgatcc  3360
ctgctcaag  actgcatag  tgattttct  aaaacgttg  aagacccag  tttgaatgt  3420
agaagagtg  ccttggtca  attcaattc  gcagcccat  acaagccgt  actgatacg  3480
gaccttctg  attctgttc  tccacatct  tacaatgag  caaaagtta  gaaggaact  3540
ataagagag  tagagatgg  cccgtttaa  cacacggtt  atgacggcc  ggacattag  3600
aaggcagct  ttgagtgta  gtacacact  ctagacagc  gtcttgaca  actggatat  3660
tttgaattt  taaatcatg  ggaagatgg  ttgaaggac  attatgata  taagatgct  3720
acattttta  tgttggtga  actatctac  ctttgtcca  gtgcagtac  acagaggtt  3780
gaccggctt  ttgagccac  acgagctac  tgtacaact  aggtgaagg  gaactctgt  3840
aagcaggag  ttgaaaagc  ggacgagtt  aagcgctcg  ccatgaggg  agtagctgc  3900
ctgctcacc  ttccagagg  agagaagag  cctctcatg  gtgagttcc  gtcacagat  3960
agctccaac  cggagctgg  agccatctt  gaaagtatc  agaaagatt  ttcgtccac  4020
aacttggaa  caatggaca  tagttagac  tgtgttcca  atgaggacc  ttacatttg  4080
ccgcacagt  cactgaacc  acaagttga  catagacac  ggagagaag  gtctagagc  4140
tcaggatgt  ccactttta  tttcattca  gggaagttt  ttcagcttt  ttccattgt  4200
gtttttgta  cttttactt  agaaatctg  atttccata  tccagaggt  gtaagacca  4260
tgatggttt  agtggttag  gcaacgttt  aaatgggaa  taaagtttg  atttatgga  4320
tgtggaaat  gggtccagt  tctgtttgc  ctgtaatgt  taggattaa  atgttaaaa  4380
tttaaaaaa  aaaaaa  4396



<210> 2384
<211> 1230
<212> PRT
<213> Rattus norvegicus
<308> BAA13432
<400> 2384

Met Ala Ser Ala Ser Tyr His Ile Ser Asn Leu Leu Glu Lys Met Thr 
  1               5                  10                  15
Ser Ser Asp Lys Asp Phe Arg Phe Met Ala Thr Asn Asp Leu Met Thr 
             20                  25                  30
Glu Leu Gln Lys Asp Ser Ile Lys Leu Asp Asp Asp Ser Glu Arg Lys 
         35                  40                  45
Val Val Lys Met Ile Leu Lys Leu Leu Glu Asp Lys Asn Gly Glu Val 
     50                  55                  60
Gln Asn Leu Ala Val Lys Cys Leu Gly Pro Leu Val Ser Lys Val Lys 
 65                  70                  75                  80
Glu Tyr Gln Val Glu Thr Ile Val Asp Thr Leu Cys Thr Asn Met Leu 
                 85                  90                  95
Ser Asp Lys Glu Gln Leu Arg Asp Ile Ser Ser Ile Gly Leu Lys Thr 
             100                105                110
Val Ile Gly Glu Leu Pro Pro Ala Ser Ser Gly Ser Ala Leu Ala Ala 
         115                120                125
Asn Val Cys Lys Lys Ile Thr Gly Arg Leu Thr Ser Ala Ile Ala Lys 
     130                135                140
Gln Glu Asp Val Ser Val Gln Leu Glu Ala Leu Asp Ile Met Ala Asp 
 145                150                155                160
Met Leu Ser Arg Gln Gly Gly Leu Leu Val Asn Phe His Pro Ser Ile 
                 165                170                175
Leu Thr Cys Leu Leu Pro Gln Leu Thr Ser Pro Arg Leu Ala Val Arg 
             180                185                190
Lys Arg Thr Ile Ile Ala Leu Gly His Leu Val Met Ser Cys Gly Asn 
         195                200                205
Ile Val Phe Val Asp Leu Ile Glu His Leu Leu Ser Glu Leu Ser Lys 
     210                215                220
Asn Asp Ser Met Ser Thr Thr Arg Thr Tyr Ile Gln Cys Ile Ala Ala 
 225                230                235                240
Ile Ser Arg Gln Ala Gly His Arg Ile Gly Glu Tyr Leu Glu Lys Ile 
                 245                250                255
Ile Pro Leu Val Val Lys Phe Cys Asn Val Asp Asp Asp Glu Leu Arg 
             260                265                270
Glu Tyr Cys Ile Gln Ala Phe Glu Ser Phe Val Arg Arg Cys Pro Lys 
         275                280                285
Glu Val Tyr Pro His Val Ser Thr Ile Ile Asn Ile Cys Leu Lys Tyr 
     290                295                300
Leu Thr Tyr Asp Pro Asn Tyr Asn Tyr Asp Asp Glu Asp Glu Asp Glu 
 305                310                315                320
Asn Ala Met Asp Ala Asp Gly Gly Asp Asp Asp Asp Gln Gly Ser Asp 
                 325                330                335
Asp Glu Tyr Ser Asp Asp Asp Asp Met Ser Trp Lys Val Arg Arg Ala 
             340                345                350
Ala Ala Lys Cys Leu Asp Ala Val Val Ser Thr Arg His Glu Met Leu 
         355                360                365
Pro Glu Phe Tyr Lys Thr Val Ser Pro Ala Leu Ile Ser Arg Phe Lys 
     370                375                380
Glu Arg Glu Glu Asn Val Lys Ala Asp Val Phe His Ala Tyr Leu Ser 
 385                390                395                400
Leu Leu Lys Gln Thr Arg Pro Val Gln Ser Trp Leu Cys Asp Pro Asp 
                 405                410                415
Ala Met Glu Gln Gly Glu Thr Pro Leu Thr Met Leu Gln Ser Gln Val 
             420                425                430
Pro Asn Ile Val Lys Ala Leu His Lys Gln Met Lys Glu Lys Ser Val 
         435                440                445
Lys Thr Arg Gln Cys Cys Phe Asn Met Leu Thr Glu Leu Val Asn Val 
     450                455                460
Leu Pro Gly Ala Leu Thr Gln His Ile Pro Val Leu Val Pro Gly Ile 
 465                470                475                480
Ile Phe Ser Leu Asn Asp Lys Ser Ser Ser Ser Asn Leu Lys Ile Asp 
                 485                490                495
Ala Leu Ser Cys Leu Tyr Val Ile Leu Cys Asn His Ser Pro Gln Val 
             500                505                510
Phe His Pro His Val Gln Ala Leu Val Pro Pro Val Val Ala Cys Val 
         515                520                525
Gly Asp Pro Phe Tyr Lys Ile Thr Ser Glu Ala Leu Leu Val Thr Gln 
     530                535                540
Gln Leu Val Lys Val Ile Arg Pro Leu Asp Gln Pro Ser Ser Phe Asp 
 545                550                555                560
Ala Thr Pro Tyr Ile Lys Asp Leu Phe Thr Cys Thr Ile Lys Arg Leu 
                 565                570                575
Lys Ala Ala Asp Ile Asp Gln Glu Val Lys Glu Arg Ala Ile Ser Cys 
             580                585                590
Met Gly Gln Ile Ile Cys Asn Leu Gly Asp Asn Leu Gly Pro Asp Leu 
         595                600                605
Ser Asn Thr Leu Gln Ile Phe Leu Glu Arg Leu Lys Asn Glu Ile Thr 
     610                615                620
Arg Leu Thr Thr Val Lys Ala Leu Thr Leu Ile Ala Gly Ser Pro Leu 
 625                630                635                640
Lys Ile Asp Leu Arg Pro Val Leu Gly Glu Gly Val Pro Ile Leu Ala 
                 645                650                655
Ser Phe Leu Arg Lys Asn Gln Arg Ala Leu Lys Leu Gly Thr Leu Ser 
             660                665                670
Ala Leu Asp Ile Leu Ile Lys Asn Tyr Ser Asp Ser Leu Thr Ala Ala 
         675                680                685
Met Ile Asp Ala Val Leu Asp Glu Leu Pro Pro Leu Ile Ser Glu Ser 
     690                695                700
Asp Met His Val Ser Gln Met Ala Ile Ser Phe Leu Thr Thr Leu Ala 
 705                710                715                720
Lys Val Tyr Pro Ser Ser Leu Ser Lys Ile Ser Gly Ser Ile Leu Asn 
                 725                730                735
Glu Leu Ile Gly Leu Val Arg Ser Pro Leu Leu Gln Gly Gly Ala Leu 
             740                745                750
Ser Ala Met Leu Asp Phe Phe Gln Ala Leu Val Val Thr Gly Thr Asn 
         755                760                765
Asn Leu Gly Tyr Met Asp Leu Leu Arg Met Leu Thr Gly Pro Val Tyr 
     770                775                780
Ser Gln Ser Thr Ala Leu Thr His Lys Gln Ser Tyr Tyr Ser Ile Ala 
 785                790                795                800
Lys Cys Val Ala Ala Leu Thr Arg Ala Cys Pro Lys Glu Gly Pro Ala 
                 805                810                815
Val Val Gly Gln Phe Ile Gln Asp Val Lys Asn Ser Arg Ser Thr Asp 
             820                825                830
Ser Ile Arg Leu Leu Ala Leu Leu Ser Leu Gly Glu Val Gly His His 
         835                840                845
Ile Asp Leu Ser Gly Gln Leu Glu Leu Lys Ser Val Ile Leu Glu Ala 
     850                855                860
Phe Ser Ser Pro Ser Glu Glu Val Lys Ser Ala Ala Ser Tyr Ala Leu 
 865                870                875                880
Gly Ser Ile Ser Val Gly Asn Leu Pro Glu Tyr Leu Pro Phe Val Leu 
                 885                890                895
Gln Glu Ile Thr Ser Gln Pro Lys Arg Gln Tyr Leu Leu Leu His Ser 
             900                905                910
Leu Lys Glu Ile Ile Ser Ser Ala Ser Val Val Gly Leu Lys Pro Tyr 
         915                920                925
Val Glu Asn Ile Trp Ala Leu Leu Leu Lys His Cys Glu Cys Ala Glu 
     930                935                940
Glu Gly Thr Arg Asn Val Val Ala Glu Cys Leu Gly Lys Leu Thr Leu 
 945                950                955                960
Ile Asp Pro Glu Thr Leu Leu Pro Arg Leu Lys Gly Tyr Leu Ile Ser 
                 965                970                975
Gly Ser Ser Tyr Ala Arg Ser Ser Val Val Thr Ala Val Lys Phe Thr 
             980                985                990
Ile Ser Asp His Pro Gln Pro Ile Asp Pro Leu Leu Lys Asn Cys Ile 
         995                1000                1005
Gly Asp Phe Leu Lys Thr Leu Glu Asp Pro Asp Leu Asn Val Arg Arg 
     1010                1015                1020
Val Ala Leu Val Thr Phe Asn Ser Ala Ala His Asn Lys Pro Ser Leu 
 1025                1030                1035                1040
Ile Arg Asp Leu Leu Asp Ser Val Leu Pro His Leu Tyr Asn Glu Thr 
                 1045                1050                1055
Lys Val Arg Lys Glu Leu Ile Arg Glu Val Glu Met Gly Pro Phe Lys 
             1060                1065                1070
His Thr Val Asp Asp Gly Leu Asp Ile Arg Lys Ala Ala Phe Glu Cys 
         1075                1080                1085
Met Tyr Thr Leu Leu Asp Ser Cys Leu Asp Arg Leu Asp Ile Phe Glu 
     1090                1095                1100
Phe Leu Asn His Val Glu Asp Gly Leu Lys Asp His Tyr Asp Ile Lys 
 1105                1110                1115                1120
Met Leu Thr Phe Leu Met Leu Val Arg Leu Ser Thr Leu Cys Pro Ser 
                 1125                1130                1135
Ala Val Leu Gln Arg Leu Asp Arg Leu Val Glu Pro Leu Arg Ala Thr 
             1140                1145                1150
Cys Thr Thr Lys Val Lys Ala Asn Ser Val Lys Gln Glu Phe Glu Lys 
         1155                1160                1165
Gln Asp Glu Leu Lys Arg Ser Ala Met Arg Ala Val Ala Ala Leu Leu 
     1170                1175                1180
Thr Ile Pro Glu Ala Glu Lys Ser Pro Leu Met Ser Glu Phe Gln Ser 
 1185                1190                1195                1200
Gln Ile Ser Ser Asn Pro Glu Leu Ala Ala Ile Phe Glu Ser Ile Gln 
                 1205                1210                1215
Lys Asp Ser Ser Ser Thr Asn Leu Glu Ser Met Asp Thr Ser 
             1220                1225                1230



<210> 2385
<211> 5387
<212> DNA
<213> Homo sapiens
<308> NM_018448
<400> 2385

gggagcgag  gcggagcga  tgggagcga  acggccctg  gtggaagtg  ctggctccc  60
gtagaggcc  ttctgtacg  cccgccgcc  atgagctcg  tctcacgcg  acagcgccg  120
cgttaggct  gctctgtag  ctcggctta  cccgggaca  gcccacgcc  cgccaggga  180
ggggcagcc  gtcgaggcg  ctccctagt  agcgtcggc  tcgcgctgc  accctggaa  240
cgggagccg  cgcgagcga  aggaggagc  ccagtggcg  cggcggcgg  ggcagcggc  300
gcgggcagc  gctccagca  cgccagcag  cgggatcga  gccgtcaac  tggcgagcg  360
ctcgtacca  atttccaat  tgctggaaa  aatgacatc  agcgacaag  actttaggt  420
tatggctac  aatgatttg  tgacggaac  gcagaaaga  tccatcaag  tggatgatg  480
tagtgaaag  aaagtagtg  aaatgattt  gaagttatt  gaagataaa  atggagagg  540
acagaattt  gctgtcaaa  gtcttggtc  tttagtgag  aaagtgaaa  aataccaag  600
agagacaat  gtagatacc  tctgcacta  catgctttc  gataaagaa  aacttcgag  660
catttcaag  attggtctt  aaacagtaa  tggagaact  cctccagct  ccagtggct  720
tgcattagc  gctaatgta  gtaaaaaga  tactggacg  cttacaagt  caatagcaa  780
acaggaaga  gtctctgtt  agctagaag  cttggatat  atggctgat  tgttgagca  840
gcaaggagg  cttcttgtt  atttccatc  ttcaattct  acctgtcta  ttccccagt  900
gaccagccc  agacttgca  tgaggaaaa  aaccattat  gctcttggc  atctggtta  960
gagctgtgg  aatatagtt  ttgtagatc  tattgaaca  ctgttgtca  agttgtcca  1020
aaatgattc  atgtcaaca  caagaacct  catacaatg  attgctgct  ttagtaggc  1080
agctggtca  agaataggt  aataccttg  gaagataat  cctttggtg  taaaatttt  1140
caatgtaga  gatgatgaa  taagagagt  ctgtattca  gcctttgaa  catttgtaa  1200
aagatgtcc  aaggaagta  atcctcatg  ttctaccat  ataaatatt  gtcttaaat  1260
tcttaccta  gatccaaat  ataattacg  tgatgaaga  gaagatgaa  atgcaatgg  1320
tgctgatgg  ggtgatgat  atgatcaag  gagtgatga  gaatacagt  atgatgatg  1380
catgagttg  aaagtgaga  gtgcagctg  gaagtgctt  gatgctgta  ttagcacaa  1440
gcatgaaat  cttccagaa  tctacaaga  cgtctctcc  gcactaata  ccagattta  1500
agagcgtga  gagaatgta  aggcagatg  ttttcacgc  tacctttct  ttttgaagc  1560
aactcgtcc  gtacaaagt  ggctatgtg  ccctgatgc  atggagcag  gagaaacac  1620
tttaacaat  cttcagagt  aggttccca  cattgttaa  gctcttcac  aacagatga  1680
agaaaaaag  gtgaagacc  gacagtgtt  ttttaacat  ttaactgag  tggtaaatg  1740
attacctgg  gccctaact  aacacattc  tgtacttgt  ccaggaatc  ttttctcac  1800
gaatgataa  tcaagctca  cgaatttga  gatcgatgc  ttgtcatgt  tatacgtaa  1860
cctctgtaa  cattctcct  aagtcttcc  tcctcacgt  caggctttg  ttcctccag  1920
ggtggcttg  gttggagac  cattttaca  aattacatc  gaagcactt  ttgttactc  1980
acagcttgt  aaagtaatt  gtcctttag  tcagccttc  tcgtttgat  caactcctt  2040
tatcaaaga  ctatttacc  gtaccatta  gagattaaa  gcagctgac  ttgatcagg  2100
agtcaagga  agggctatt  cctgtatgg  acaaattat  tgcaacctt  gagacaatt  2160
gggttctga  ttgcctaat  cacttcaga  tttcttgga  agactaaag  atgaaatta  2220
caggttaac  acagtaaag  cattgacac  gattgctgg  tcacctttg  agatagatt  2280
gaggcctgt  ctgggagaa  gggttccta  ccttgcttc  tttcttaga  aaaaccaga  2340
agctttgaa  ctgggtact  tttctgccc  tgatattct  ataaaaaac  atagtgaca  2400
cttgacagc  gccatgatt  atgcagttc  agatgagct  ccacctctt  tcagcgaaa  2460
tgatatgca  gtttcacaa  tggccatca  ttttcttac  actttggca  aagtatatc  2520
ctcctccct  tcaaagata  gtggatcca  tctcaatga  cttattgga  ttgtgagat  2580
acccttatt  cagggggga  ctcttagtg  catgctaga  tttttccaa  ctctggttg  2640
cactggaac  aataattta  gatacatgg  tttgttgcg  atgctgact  gtccagttt  2700
ctctcagag  acagctctt  ctcataagc  gtcttatta  tccattgcc  aatgtgtag  2760
tgcccttac  cgagcatgc  ctaaagagg  accagctgt  gtaggtcag  ttattcaag  2820
tgtcaagaa  tcaaggtct  cagattcca  tcgtctctt  gctctactt  ctcttggag  2880
agttgggca  catattgac  taagtggac  gttggaact  aaatctgta  tactagaag  2940
tttctcatc  cctagtgaa  aagtcaaat  agctgcatc  tatgcatta  gcagcatta  3000
tgtgggcaa  cttcctgaa  atctgccgt  tgtcctgca  gaaataact  gtcaaccca  3060
aaggcagta  cttttactt  attccttga  ggaaattat  agctctgca  cagtggtgg  3120
ccttaaacc  tatgttgaa  acatctggg  cttattact  aagcactgt  agtgtgcag  3180
ggaaggaac  agaaatgtt  ttgctgaat  tctaggaaa  ctcactcta  ttgatccag  3240
aactctcct  ccacggctt  aggggtact  gatatcagg  tcatcatat  cccgaagct  3300
agtggttac  gctgtgaaa  ttacaattt  tgaccatcc  caacctatt  atccactgt  3360
aaagaactg  ataggtgat  tcctaaaaa  tttggaaga  ccagatttg  atgtgagaa  3420
agtagcctt  gtcacattt  attcagcag  acataacaa  ccatcatta  taagggatc  3480
attggatac  gttcttcca  atctttaca  tgaaacaaa  gttagaaag  agcttataa  3540
agaggtaga  atgggtcca  ttaaacata  ggttgatga  ggtctggat  ttagaaagg  3600
agcatttga  tgtatgtac  cacttctag  cagttgtct  gatagactt  atatctttg  3660
atttctaaa  catgttgaa  atggtttga  ggaccatta  gatattaag  tgctgacat  3720
tttaatgtt  gtgagactg  ctacccttt  tccaagtgc  gtactgcag  ggttggacc  3780
acttgttga  ccattacgt  caacatgta  aactaaggt  aaggcaaac  cagtaaagc  3840
ggagtttga  aaacaagat  aattaaagc  atctgccat  agagcagta  cagcactgc  3900
aaccattcc  gaagcagag  agagtccac  gatgagtga  ttccagtca  agatcagtt  3960
taaccctga  ctggcggct  tctttgaaa  tatccagaa  gattcatca  ctactaact  4020
ggaatcaat  gacactagt  agatgtttg  tcaccatgg  gaccattac  tatgaccat  4080
caatgcact  aattgacag  ttaatcata  gacatggaa  gagaagtgt  taaaagctt  4140
aaaatgttc  acttttttt  ccttcatgg  gactgtttg  ttggctttc  tccattgtt  4200
tttttgtag  atttatttc  gaaatgtgt  tttccataa  ccagaggtt  taaaaccac  4260
agtgtttta  tggttacag  aacatttga  atggaaact  aaagttagg  ttttatgga  4320
tatggagat  gggtccagt  tctatttac  ctgtaatgt  taggattaa  atgttaaaa  4380
tttgtgacc  tgaatttct  tcttttata  attttctca  ttaaaaatc  aaaatcttg  4440
aaaacaaaa  ccatgtttc  ttttcttgt  taacttttt  ttttcagca  cataaattg  4500
tttttagct  gcagacaag  atatccata  aagatttgt  aaccatttc  gagagtttg  4560
caattttta  aagataata  ggtatcatt  ttaagtatg  aaattaaca  tatccctgt  4620
gcgcacact  attttgcat  agtaagttt  caaatatgt  tcgtctgta  agcagcatg  4680
gcagattat  cataatata  aagttaaaa  aagtattag  gcaattttc  gatatttat  4740
tttgcacag  aaacacatt  tctggagag  aagaaagga  aatttttga  acttgggtt  4800
tcttaatgc  agtgtgaat  tgcagatgt  ttcagaaaa  caagtcaca  taacaattt  4860
ccacttttt  ctattataa  tcttcttac  taaattttg  atatttagt  tttctcagt  4920
acccatttg  gtgtgtgtg  ttccactta  aaattctta  aaccagatt  ttctttcat  4980
ccgtttgga  gtctacatt  cttatcaaa  gatataaat  ctgtgtatg  ttttgaatt  5040
tatttttag  aaaattctg  agccagcta  cacaggttt  ttagctaat  atagtattt  5100
cttttagtt  agttaggtt  ttccccatc  cctgtagag  gaatttaca  attgtattg  5160
gtaagtgtt  actactttt  ctgattaag  gatctgtgc  ggggaacaa  gcttttgca  5220
taccttata  tgtagttaa  attttattt  acatatcct  cagtgagct  atttcacac  5280
gtagcctct  ccttaaaat  tgtggtgct  ctgtaacag  aagaactaa  tctgaaata  5340
aagacatct  ctaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaa  5387



<210> 2386
<211> 1230
<212> PRT
<213> Homo sapiens
<308> NP_060918
<400> 2386

Met Ala Ser Ala Ser Tyr His Ile Ser Asn Leu Leu Glu Lys Met Thr 
  1               5                  10                  15
Ser Ser Asp Lys Asp Phe Arg Phe Met Ala Thr Asn Asp Leu Met Thr 
             20                  25                  30
Glu Leu Gln Lys Asp Ser Ile Lys Leu Asp Asp Asp Ser Glu Arg Lys 
         35                  40                  45
Val Val Lys Met Ile Leu Lys Leu Leu Glu Asp Lys Asn Gly Glu Val 
     50                  55                  60
Gln Asn Leu Ala Val Lys Cys Leu Gly Pro Leu Val Ser Lys Val Lys 
 65                  70                  75                  80
Glu Tyr Gln Val Glu Thr Ile Val Asp Thr Leu Cys Thr Asn Met Leu 
                 85                  90                  95
Ser Asp Lys Glu Gln Leu Arg Asp Ile Ser Ser Ile Gly Leu Lys Thr 
             100                105                110
Val Ile Gly Glu Leu Pro Pro Ala Ser Ser Gly Ser Ala Leu Ala Ala 
         115                120                125
Asn Val Cys Lys Lys Ile Thr Gly Arg Leu Thr Ser Ala Ile Ala Lys 
     130                135                140
Gln Glu Asp Val Ser Val Gln Leu Glu Ala Leu Asp Ile Met Ala Asp 
 145                150                155                160
Met Leu Ser Arg Gln Gly Gly Leu Leu Val Asn Phe His Pro Ser Ile 
                 165                170                175
Leu Thr Cys Leu Leu Pro Gln Leu Thr Ser Pro Arg Leu Ala Val Arg 
             180                185                190
Lys Arg Thr Ile Ile Ala Leu Gly His Leu Val Met Ser Cys Gly Asn 
         195                200                205
Ile Val Phe Val Asp Leu Ile Glu His Leu Leu Ser Glu Leu Ser Lys 
     210                215                220
Asn Asp Ser Met Ser Thr Thr Arg Thr Tyr Ile Gln Cys Ile Ala Ala 
 225                230                235                240
Ile Ser Arg Gln Ala Gly His Arg Ile Gly Glu Tyr Leu Glu Lys Ile 
                 245                250                255
Ile Pro Leu Val Val Lys Phe Cys Asn Val Asp Asp Asp Glu Leu Arg 
             260                265                270
Glu Tyr Cys Ile Gln Ala Phe Glu Ser Phe Val Arg Arg Cys Pro Lys 
         275                280                285
Glu Val Tyr Pro His Val Ser Thr Ile Ile Asn Ile Cys Leu Lys Tyr 
     290                295                300
Leu Thr Tyr Asp Pro Asn Tyr Asn Tyr Asp Asp Glu Asp Glu Asp Glu 
 305                310                315                320
Asn Ala Met Asp Ala Asp Gly Gly Asp Asp Asp Asp Gln Gly Ser Asp 
                 325                330                335
Asp Glu Tyr Ser Asp Asp Asp Asp Met Ser Trp Lys Val Arg Arg Ala 
             340                345                350
Ala Ala Lys Cys Leu Asp Ala Val Val Ser Thr Arg His Glu Met Leu 
         355                360                365
Pro Glu Phe Tyr Lys Thr Val Ser Pro Ala Leu Ile Ser Arg Phe Lys 
     370                375                380
Glu Arg Glu Glu Asn Val Lys Ala Asp Val Phe His Ala Tyr Leu Ser 
 385                390                395                400
Leu Leu Lys Gln Thr Arg Pro Val Gln Ser Trp Leu Cys Asp Pro Asp 
                 405                410                415
Ala Met Glu Gln Gly Glu Thr Pro Leu Thr Met Leu Gln Ser Gln Val 
             420                425                430
Pro Asn Ile Val Lys Ala Leu His Lys Gln Met Lys Glu Lys Ser Val 
         435                440                445
Lys Thr Arg Gln Cys Cys Phe Asn Met Leu Thr Glu Leu Val Asn Val 
     450                455                460
Leu Pro Gly Ala Leu Thr Gln His Ile Pro Val Leu Val Pro Gly Ile 
 465                470                475                480
Ile Phe Ser Leu Asn Asp Lys Ser Ser Ser Ser Asn Leu Lys Ile Asp 
                 485                490                495
Ala Leu Ser Cys Leu Tyr Val Ile Leu Cys Asn His Ser Pro Gln Val 
             500                505                510
Phe His Pro His Val Gln Ala Leu Val Pro Pro Val Val Ala Cys Val 
         515                520                525
Gly Asp Pro Phe Tyr Lys Ile Thr Ser Glu Ala Leu Leu Val Thr Gln 
     530                535                540
Gln Leu Val Lys Val Ile Arg Pro Leu Asp Gln Pro Ser Ser Phe Asp 
 545                550                555                560
Ala Thr Pro Tyr Ile Lys Asp Leu Phe Thr Cys Thr Ile Lys Arg Leu 
                 565                570                575
Lys Ala Ala Asp Ile Asp Gln Glu Val Lys Glu Arg Ala Ile Ser Cys 
             580                585                590
Met Gly Gln Ile Ile Cys Asn Leu Gly Asp Asn Leu Gly Ser Asp Leu 
         595                600                605
Pro Asn Thr Leu Gln Ile Phe Leu Glu Arg Leu Lys Asn Glu Ile Thr 
     610                615                620
Arg Leu Thr Thr Val Lys Ala Leu Thr Leu Ile Ala Gly Ser Pro Leu 
 625                630                635                640
Lys Ile Asp Leu Arg Pro Val Leu Gly Glu Gly Val Pro Ile Leu Ala 
                 645                650                655
Ser Phe Leu Arg Lys Asn Gln Arg Ala Leu Lys Leu Gly Thr Leu Ser 
             660                665                670
Ala Leu Asp Ile Leu Ile Lys Asn Tyr Ser Asp Ser Leu Thr Ala Ala 
         675                680                685
Met Ile Asp Ala Val Leu Asp Glu Leu Pro Pro Leu Ile Ser Glu Ser 
     690                695                700
Asp Met His Val Ser Gln Met Ala Ile Ser Phe Leu Thr Thr Leu Ala 
 705                710                715                720
Lys Val Tyr Pro Ser Ser Leu Ser Lys Ile Ser Gly Ser Ile Leu Asn 
                 725                730                735
Glu Leu Ile Gly Leu Val Arg Ser Pro Leu Leu Gln Gly Gly Ala Leu 
             740                745                750
Ser Ala Met Leu Asp Phe Phe Gln Ala Leu Val Val Thr Gly Thr Asn 
         755                760                765
Asn Leu Gly Tyr Met Asp Leu Leu Arg Met Leu Thr Gly Pro Val Tyr 
     770                775                780
Ser Gln Ser Thr Ala Leu Thr His Lys Gln Ser Tyr Tyr Ser Ile Ala 
 785                790                795                800
Lys Cys Val Ala Ala Leu Thr Arg Ala Cys Pro Lys Glu Gly Pro Ala 
                 805                810                815
Val Val Gly Gln Phe Ile Gln Asp Val Lys Asn Ser Arg Ser Thr Asp 
             820                825                830
Ser Ile Arg Leu Leu Ala Leu Leu Ser Leu Gly Glu Val Gly His His 
         835                840                845
Ile Asp Leu Ser Gly Gln Leu Glu Leu Lys Ser Val Ile Leu Glu Ala 
     850                855                860
Phe Ser Ser Pro Ser Glu Glu Val Lys Ser Ala Ala Ser Tyr Ala Leu 
 865                870                875                880
Gly Ser Ile Ser Val Gly Asn Leu Pro Glu Tyr Leu Pro Phe Val Leu 
                 885                890                895
Gln Glu Ile Thr Ser Gln Pro Lys Arg Gln Tyr Leu Leu Leu His Ser 
             900                905                910
Leu Lys Glu Ile Ile Ser Ser Ala Ser Val Val Gly Leu Lys Pro Tyr 
         915                920                925
Val Glu Asn Ile Trp Ala Leu Leu Leu Lys His Cys Glu Cys Ala Glu 
     930                935                940
Glu Gly Thr Arg Asn Val Val Ala Glu Cys Leu Gly Lys Leu Thr Leu 
 945                950                955                960
Ile Asp Pro Glu Thr Leu Leu Pro Arg Leu Lys Gly Tyr Leu Ile Ser 
                 965                970                975
Gly Ser Ser Tyr Ala Arg Ser Ser Val Val Thr Ala Val Lys Phe Thr 
             980                985                990
Ile Ser Asp His Pro Gln Pro Ile Asp Pro Leu Leu Lys Asn Cys Ile 
         995                1000                1005
Gly Asp Phe Leu Lys Thr Leu Glu Asp Pro Asp Leu Asn Val Arg Arg 
     1010                1015                1020
Val Ala Leu Val Thr Phe Asn Ser Ala Ala His Asn Lys Pro Ser Leu 
 1025                1030                1035                1040
Ile Arg Asp Leu Leu Asp Thr Val Leu Pro His Leu Tyr Asn Glu Thr 
                 1045                1050                1055
Lys Val Arg Lys Glu Leu Ile Arg Glu Val Glu Met Gly Pro Phe Lys 
             1060                1065                1070
His Thr Val Asp Asp Gly Leu Asp Ile Arg Lys Ala Ala Phe Glu Cys 
         1075                1080                1085
Met Tyr Thr Leu Leu Asp Ser Cys Leu Asp Arg Leu Asp Ile Phe Glu 
     1090                1095                1100
Phe Leu Asn His Val Glu Asp Gly Leu Lys Asp His Tyr Asp Ile Lys 
 1105                1110                1115                1120
Met Leu Thr Phe Leu Met Leu Val Arg Leu Ser Thr Leu Cys Pro Ser 
                 1125                1130                1135
Ala Val Leu Gln Arg Leu Asp Arg Leu Val Glu Pro Leu Arg Ala Thr 
             1140                1145                1150
Cys Thr Thr Lys Val Lys Ala Asn Ser Val Lys Gln Glu Phe Glu Lys 
         1155                1160                1165
Gln Asp Glu Leu Lys Arg Ser Ala Met Arg Ala Val Ala Ala Leu Leu 
     1170                1175                1180
Thr Ile Pro Glu Ala Glu Lys Ser Pro Leu Met Ser Glu Phe Gln Ser 
 1185                1190                1195                1200
Gln Ile Ser Ser Asn Pro Glu Leu Ala Ala Ile Phe Glu Ser Ile Gln 
                 1205                1210                1215
Lys Asp Ser Ser Ser Thr Asn Leu Glu Ser Met Asp Thr Ser 
             1220                1225                1230



<210> 2387
<211> 6849
<212> DNA
<213> Rattus norvegicus
<308> J01435
<400> 2387

ccctcacag  attaagtac  cttacccta  cgctttcct  ccaactaat  acatagaag  60
ttaggatat  cagttcaag  gccttcaaa  cccttagaa  acaaacaag  ttaacttct  120
ataaggact  taagactat  tcttacatc  gttaaatgc  aatcaactg  tttaattaa  180
ctaaatcct  aactagatt  gaaggattc  aacctacga  aatttagtt  acaactaaa  240
accctactt  ctggcttca  tctacttct  ccgcctatc  gaaaagagg  gggagaagc  300
ttagtagag  agattctct  caccttcca  tttgcaatt  gacatgata  tcaccttaa  360
gctttttgg  aaaaagggg  ctcaacccc  gtctttaga  ttacagtct  atgcttact  420
agccatttt  cctatgttc  taaacggtt  actcttttc  actaaccct  aagatatcg  480
aaccctcta  ctattattt  gagcctgag  aggaatagt  gggacagct  taagtattc  540
aattcgagc  gaactagga  agctaggcg  actcctagg  gatgaccaa  tctataatg  600
cctcgtcac  gcccatgca  tcgtaataa  tttctttat  gtaatacct  taataattg  660
aggcttcgg  aactgactt  taccactaa  aattggagc  cctgatata  cattcccac  720
aataaataa  ataagcttt  gactgcttc  tccatcatt  ctactcctt  tagcatcct  780
catagtaga  gctggagct  gaacaggat  aacagtata  cccccctta  ccggaaacc  840
agcccatgc  ggggtatcc  tagatttaa  tattttttc  ctccaccta  ccggggtgt  900
ttctatctt  ggagctatc  actttatca  cactatcat  aatataaaa  cccctgcta  960
aacccaata  cagacacct  tctttgtat  atccgtact  attacagcc  tcctactac  1020
tctctcact  ccagtatta  cagcaggta  cactatact  cttacagac  gaaatctaa  1080
tactacttt  ttcgacccc  ctggaggcg  aggcccaat  ctttatcaa  acctattct  1140
attcttcgg  cacccagaa  tgtacatct  aattcttct  gggtttgaa  ttatttcac  1200
tgtagttac  tattactct  gaaaaaaag  acccttcgg  tatataggt  tggtatgaa  1260
cataatatc  attggcttc  taggattta  tgtatgagc  catcacata  tcactgtag  1320
cctggatgt  gacacccga  cctacttta  atctgccac  ataattatc  caattccta  1380
aggcgtaaa  gtattcagc  gactcgcta  actacatgg  ggaaatatc  aatgatccc  1440
cgccatatt  tgagcctta  ggtttatct  cttattcac  gtagggggc  taacaggga  1500
cgtactatc  aactcatcc  ttgacattg  acttcatga  acatactac  tagtagctc  1560
cttccacta  gtcttatct  taggagcag  attcgccat  atagcttgc  tcgtccact  1620
attcccact  ttctcaggc  ataccctaa  tgacacatg  gcaaaagcc  tctttgcca  1680
tatatttgt  ggtgtaaac  taacatttt  tcctcaaca  ttcctagga  tagcaggga  1740
acctcgtcg  tactctgat  atccagatg  ttataccac  tgaaataca  tctcctcta  1800
aggctcatt  atctcactt  cggccgtcc  tgtaatgat  ttcatgatt  gagaagcct  1860
cgcatcaaa  cgagaagtg  tctcaattt  ctactcttc  actaaccta  aatgactgc  1920
tggatgccc  ccaccttac  acacattcg  agaaccttc  tatgtaaaa  ttaaataag  1980
aaggaagga  tcgaacccc  tacaactgg  ttcaagcca  tttcataac  attatgtct  2040
tctcaatga  atattagta  aataattac  taaccttgt  aaggttaag  tatagactt  2100
aatctatat  tcttacatg  cttacccat  tcaacttgg  ttacaagac  ccacatcac  2160
aatcataga  gaacttaca  actttcatg  ccacaccct  ataattgta  tcctcatca  2220
ctccctagt  ctttatatt  tttcactaa  actaacaac  aaactaaca  acacaagca  2280
aatagacgc  cangaagta  aaacaattt  aacaattct  ccagctgtc  ttcttattc  2340
aatcgccct  ccctcccta  gaattctat  cataataga  gagattaat  acccagttc  2400
aacagtaaa  actatagga  accaatgat  ctgaagcta  gaatatact  actatgaag  2460
cctatgctt  gactcctac  taatcccaa  caatgacct  aaactaggt  aacttcgct  2520
attagaagt  gataatcgg  tagtcttac  aatagaact  ccaattcgt  tactaatct  2580
atccgaaga  gtcctgcac  catgaccca  cccttcact  gggttaaaa  ccgacgcaa  2640
ccccggccg  ctaaaccaa  ctacagtca  atcaaaccg  ctaggtcta  tctatggcc  2700
atgctctga  atttgcggc  caaatcaca  cttcatact  attgtacta  aaatagtgc  2760
tctaaaata  ttcgaaaac  gatcagctt  tataattta  actcattgc  aagcttaga  2820
cgttaacct  ttaagttaa  gttagagac  acaaatctc  acattgaca  gccacaact  2880
gacacatcc  catgattta  tacaatcat  tcctcaata  ccacactat  taatttatt  2940
caattaaaa  tttcttccc  aacctttcc  gcacctccc  cacccaaaa  tatagccac  3000
gaaaaaacg  ataaccctt  agaatcaaa  tgaacgaaa  tctatttcc  tctttcatt  3060
cccccacaa  aataggtct  ccaattgtt  tgaccatta  tatgttccc  tcaattcta  3120
tcccatcat  agaacgcct  atcagcaac  gactacact  atttcaaca  tgactaatc  3180
aacttatca  caaacaaat  atgttaatt  acacaccaa  aggacgaac  tgagcccta  3240
taattgtat  cctaattat  tttatcggc  caaccaacc  tctagggct  cttccccat  3300
catttaccc  taccactca  ctatctata  acctaagca  agccatccc  ctatgagca  3360
gagccgtaa  tctaggctt  cgacacaaa  taaaaaatt  tttagccca  ttcttaccg  3420
aaggaaccc  catctcact  attcccata  taatcatca  cgaaactat  agcctattt  3480
ttcaaccga  agcactagc  gtacgacta  cagcaaaca  tacagcagg  catctatta  3540
tgcatctaa  cggaggagc  accctagta  ttatagaca  cagcccacc  accgctaca  3600
ttacattta  tattctact  ctacttaca  tacttgaat  tgtcgtagc  ttaattcaa  3660
cctatgtat  cacccttct  gtaagcctg  acctacatg  taacacata  tgacccacc  3720
aacccatgc  taccatata  taaacccaa  cccatgacc  ctaacagga  ccctatcag  3780
tcttctact  acatccggc  tagtaatat  attccatta  aactccaca  ttctcctat  3840
attaggcct  ctgacaaac  tcctaacta  atatcaatg  tgacgagat  tcatccgtg  3900
aggaacata  caaggccac  acaccccta  tgtacaaaa  ggcctccga  acggaataa  3960
cctgtttat  gtctccgaa  tattcttct  tgccggatt  ttctgagca  tttatcatt  4020
cagcctagt  cctacccac  acctaggcg  ttgctgacc  ccaacagga  tcacccctt  4080
aaatcccct  gaagtaccc  ttctaaata  atcagtcct  ttagcatca  gagtctcaa  4140
tacatgagc  catcacagc  taatagaag  caaccgaaa  catataaac  aagccctac  4200
aatcaccat  ctcttagga  tatatttca  tatcttaca  gcctcagag  atttcgaaa  4260
atcattttc  atctcagac  gaatttacg  ctcaacatt  ttcatagca  cgggatttc  4320
tggccttca  gtaattatt  gctcaactt  cctaattgt  tgtctacta  gacaactaa  4380
attccactt  acatcaaaa  atcatttcg  atttgaagc  gcagcatga  actgacact  4440
cgtagatgt  gtttgacta  tcctatacg  ttctatcta  tgatgagga  cctactccc  4500
tagtataaa  aatacaact  acttccaat  agttaattc  gaaaaaact  agaagagag  4560
aattaacct  cccattatc  tcacaatta  catcacctt  tcttttatc  tcatttcaa  4620
tgcattctg  ttgcctcaa  taaacttat  ctccgaaaa  gcaaaccca  atgaatgtg  4680
cttcgaccc  acaagttct  cacgccttc  tttttcaat  aaatttttc  tagtagcca  4740
tacatttct  ctattcgac  tagaaatcg  cttactact  cccctccca  gagcgattc  4800
aacaaccaa  accgctaca  taatagcaa  tgcctttat  ttagtcact  ttttagctc  4860
tggcctaag  tacgaatga  cacaaaaag  actagaatg  acagaataa  tggtaatta  4920
tttaaataa  attaatgat  tcgactcat  agattatga  aataatcat  attaccaac  4980
atgacatct  ctttcctaa  tttaactat  gcctttaca  tatctctac  aggtacttt  5040
atatttcgc  cccacttaa  atctactct  ctctgccta  aaggaataa  actatcact  5100
tttgtcata  cttcaacat  cacattaaa  tccaactcc  taatctcca  aaccatccc  5160
attaccatt  tagtttttg  agcctgcga  gtagcagta  gtttagcct  actagtaaa  5220
atttcaaat  cccacggaa  agactacgt  caaaacctc  accttctac  atgttaaaa  5280
tcattttcc  atctatcat  ctcctccca  taacatgac  ctcagccaa  aaaaaaatc  5340
gaaccaatg  cacctccta  agctttcta  tgagcctat  aagcttatc  ctcctatga  5400
aaaatgacg  aaattacct  aatttctca  ttatattct  ctccgatcc  ttatccacc  5460
cactaatca  tctaacaac  tgactcctc  cactaataa  gctcgctag  caaaatcac  5520
taaaaaaag  aaatataat  catcaaaaa  tttacatct  aatacttat  agcctccaa  5580
ttttactca  cataacatt  tccgcaaca  aactaattt  attttatat  ctgttcgaa  5640
ccactctaa  cccaacact  attatcatt  cacgatgag  caaccaaac  gaacgctta  5700
atgcaggaa  ttatttcct  ttttataca  taattggct  catcccact  ttaattgcc  5760
tcatttcaa  ccaaaactc  ataggaaca  tcaacttcc  aatcctctc  ctcacaaca  5820
accccctac  ctcaacatg  tccaacacc  ttctatgac  agcatgtat  atagcattt  5880
taatcaaaa  accattata  ggagtccat  tatgattac  aaaagccca  gtagaagct  5940
caattgcag  ctctataat  ttagcagca  ttctcctaa  gctaggggg  tatgggata  6000
tacgagttt  catcattct  gacccccta  caaaatctt  agcctaccc  ttcatcatc  6060
tctcattat  aggcataat  ataactagc  cggtctgcc  acgccaaac  gatctaaaa  6120
cattaattg  ttactcatc  gtaagccat  tagccctag  catcacagc  attataatc  6180
agacaccat  aagcttcat  ggagctaca  tactaataa  cgcccacgg  ttaacctca  6240
cactcttat  ctgcctagc  aacaccaac  acgaacgaa  tcacagccg  actataatt  6300
tagctcgag  attacaaat  atcttttca  tgatagcaa  atgatgatt  ttagcaagc  6360
tagccaacc  agcactacc  cccctaatt  acctcatag  cgagttatt  attgttata  6420
caacatttt  ctgatcgaa  ccctctatc  tccttatag  aactaacat  gtcactaca  6480
gaatatact  aatatatat  attatcaca  cccaacgag  aaaactaac  agccacata  6540
acaacctcc  accttccca  acacgagaa  taacactca  agctctaca  attattccc  6600
tcatactat  aacaatcaa  cctaaactc  tcacaggcc  aacaatatg  agatatagt  6660
tacaaaaaa  attagactg  gaatctaac  acaggaaat  aaattcctt  tttaccaag  6720
aagtatgca  gaactgcta  ttcatgcac  catacctaa  acatatggc  ttcttactt  6780
tataggata  aagtaatcc  ttggtctta  gaaccaaaa  ccttggtgc  actccaaat  6840
aaagtaata  6849



<210> 2388
<211> 6849
<212> DNA
<213> Rattus norvegicus
<308> J01435
<400> 2388

ccctcacag  attaagtac  cttacccta  cgctttcct  ccaactaat  acatagaag  60
ttaggatat  cagttcaag  gccttcaaa  cccttagaa  acaaacaag  ttaacttct  120
ataaggact  taagactat  tcttacatc  gttaaatgc  aatcaactg  tttaattaa  180
ctaaatcct  aactagatt  gaaggattc  aacctacga  aatttagtt  acaactaaa  240
accctactt  ctggcttca  tctacttct  ccgcctatc  gaaaagagg  gggagaagc  300
ttagtagag  agattctct  caccttcca  tttgcaatt  gacatgata  tcaccttaa  360
gctttttgg  aaaaagggg  ctcaacccc  gtctttaga  ttacagtct  atgcttact  420
agccatttt  cctatgttc  taaacggtt  actcttttc  actaaccct  aagatatcg  480
aaccctcta  ctattattt  gagcctgag  aggaatagt  gggacagct  taagtattc  540
aattcgagc  gaactagga  agctaggcg  actcctagg  gatgaccaa  tctataatg  600
cctcgtcac  gcccatgca  tcgtaataa  tttctttat  gtaatacct  taataattg  660
aggcttcgg  aactgactt  taccactaa  aattggagc  cctgatata  cattcccac  720
aataaataa  ataagcttt  gactgcttc  tccatcatt  ctactcctt  tagcatcct  780
catagtaga  gctggagct  gaacaggat  aacagtata  cccccctta  ccggaaacc  840
agcccatgc  ggggtatcc  tagatttaa  tattttttc  ctccaccta  ccggggtgt  900
ttctatctt  ggagctatc  actttatca  cactatcat  aatataaaa  cccctgcta  960
aacccaata  cagacacct  tctttgtat  atccgtact  attacagcc  tcctactac  1020
tctctcact  ccagtatta  cagcaggta  cactatact  cttacagac  gaaatctaa  1080
tactacttt  ttcgacccc  ctggaggcg  aggcccaat  ctttatcaa  acctattct  1140
attcttcgg  cacccagaa  tgtacatct  aattcttct  gggtttgaa  ttatttcac  1200
tgtagttac  tattactct  gaaaaaaag  acccttcgg  tatataggt  tggtatgaa  1260
cataatatc  attggcttc  taggattta  tgtatgagc  catcacata  tcactgtag  1320
cctggatgt  gacacccga  cctacttta  atctgccac  ataattatc  caattccta  1380
aggcgtaaa  gtattcagc  gactcgcta  actacatgg  ggaaatatc  aatgatccc  1440
cgccatatt  tgagcctta  ggtttatct  cttattcac  gtagggggc  taacaggga  1500
cgtactatc  aactcatcc  ttgacattg  acttcatga  acatactac  tagtagctc  1560
cttccacta  gtcttatct  taggagcag  attcgccat  atagcttgc  tcgtccact  1620
attcccact  ttctcaggc  ataccctaa  tgacacatg  gcaaaagcc  tctttgcca  1680
tatatttgt  ggtgtaaac  taacatttt  tcctcaaca  ttcctagga  tagcaggga  1740
acctcgtcg  tactctgat  atccagatg  ttataccac  tgaaataca  tctcctcta  1800
aggctcatt  atctcactt  cggccgtcc  tgtaatgat  ttcatgatt  gagaagcct  1860
cgcatcaaa  cgagaagtg  tctcaattt  ctactcttc  actaaccta  aatgactgc  1920
tggatgccc  ccaccttac  acacattcg  agaaccttc  tatgtaaaa  ttaaataag  1980
aaggaagga  tcgaacccc  tacaactgg  ttcaagcca  tttcataac  attatgtct  2040
tctcaatga  atattagta  aataattac  taaccttgt  aaggttaag  tatagactt  2100
aatctatat  tcttacatg  cttacccat  tcaacttgg  ttacaagac  ccacatcac  2160
aatcataga  gaacttaca  actttcatg  ccacaccct  ataattgta  tcctcatca  2220
ctccctagt  ctttatatt  tttcactaa  actaacaac  aaactaaca  acacaagca  2280
aatagacgc  cangaagta  aaacaattt  aacaattct  ccagctgtc  ttcttattc  2340
aatcgccct  ccctcccta  gaattctat  cataataga  gagattaat  acccagttc  2400
aacagtaaa  actatagga  accaatgat  ctgaagcta  gaatatact  actatgaag  2460
cctatgctt  gactcctac  taatcccaa  caatgacct  aaactaggt  aacttcgct  2520
attagaagt  gataatcgg  tagtcttac  aatagaact  ccaattcgt  tactaatct  2580
atccgaaga  gtcctgcac  catgaccca  cccttcact  gggttaaaa  ccgacgcaa  2640
ccccggccg  ctaaaccaa  ctacagtca  atcaaaccg  ctaggtcta  tctatggcc  2700
atgctctga  atttgcggc  caaatcaca  cttcatact  attgtacta  aaatagtgc  2760
tctaaaata  ttcgaaaac  gatcagctt  tataattta  actcattgc  aagcttaga  2820
cgttaacct  ttaagttaa  gttagagac  acaaatctc  acattgaca  gccacaact  2880
gacacatcc  catgattta  tacaatcat  tcctcaata  ccacactat  taatttatt  2940
caattaaaa  tttcttccc  aacctttcc  gcacctccc  cacccaaaa  tatagccac  3000
gaaaaaacg  ataaccctt  agaatcaaa  tgaacgaaa  tctatttcc  tctttcatt  3060
cccccacaa  aataggtct  ccaattgtt  tgaccatta  tatgttccc  tcaattcta  3120
tcccatcat  agaacgcct  atcagcaac  gactacact  atttcaaca  tgactaatc  3180
aacttatca  caaacaaat  atgttaatt  acacaccaa  aggacgaac  tgagcccta  3240
taattgtat  cctaattat  tttatcggc  caaccaacc  tctagggct  cttccccat  3300
catttaccc  taccactca  ctatctata  acctaagca  agccatccc  ctatgagca  3360
gagccgtaa  tctaggctt  cgacacaaa  taaaaaatt  tttagccca  ttcttaccg  3420
aaggaaccc  catctcact  attcccata  taatcatca  cgaaactat  agcctattt  3480
ttcaaccga  agcactagc  gtacgacta  cagcaaaca  tacagcagg  catctatta  3540
tgcatctaa  cggaggagc  accctagta  ttatagaca  cagcccacc  accgctaca  3600
ttacattta  tattctact  ctacttaca  tacttgaat  tgtcgtagc  ttaattcaa  3660
cctatgtat  cacccttct  gtaagcctg  acctacatg  taacacata  tgacccacc  3720
aacccatgc  taccatata  taaacccaa  cccatgacc  ctaacagga  ccctatcag  3780
tcttctact  acatccggc  tagtaatat  attccatta  aactccaca  ttctcctat  3840
attaggcct  ctgacaaac  tcctaacta  atatcaatg  tgacgagat  tcatccgtg  3900
aggaacata  caaggccac  acaccccta  tgtacaaaa  ggcctccga  acggaataa  3960
cctgtttat  gtctccgaa  tattcttct  tgccggatt  ttctgagca  tttatcatt  4020
cagcctagt  cctacccac  acctaggcg  ttgctgacc  ccaacagga  tcacccctt  4080
aaatcccct  gaagtaccc  ttctaaata  atcagtcct  ttagcatca  gagtctcaa  4140
tacatgagc  catcacagc  taatagaag  caaccgaaa  catataaac  aagccctac  4200
aatcaccat  ctcttagga  tatatttca  tatcttaca  gcctcagag  atttcgaaa  4260
atcattttc  atctcagac  gaatttacg  ctcaacatt  ttcatagca  cgggatttc  4320
tggccttca  gtaattatt  gctcaactt  cctaattgt  tgtctacta  gacaactaa  4380
attccactt  acatcaaaa  atcatttcg  atttgaagc  gcagcatga  actgacact  4440
cgtagatgt  gtttgacta  tcctatacg  ttctatcta  tgatgagga  cctactccc  4500
tagtataaa  aatacaact  acttccaat  agttaattc  gaaaaaact  agaagagag  4560
aattaacct  cccattatc  tcacaatta  catcacctt  tcttttatc  tcatttcaa  4620
tgcattctg  ttgcctcaa  taaacttat  ctccgaaaa  gcaaaccca  atgaatgtg  4680
cttcgaccc  acaagttct  cacgccttc  tttttcaat  aaatttttc  tagtagcca  4740
tacatttct  ctattcgac  tagaaatcg  cttactact  cccctccca  gagcgattc  4800
aacaaccaa  accgctaca  taatagcaa  tgcctttat  ttagtcact  ttttagctc  4860
tggcctaag  tacgaatga  cacaaaaag  actagaatg  acagaataa  tggtaatta  4920
tttaaataa  attaatgat  tcgactcat  agattatga  aataatcat  attaccaac  4980
atgacatct  ctttcctaa  tttaactat  gcctttaca  tatctctac  aggtacttt  5040
atatttcgc  cccacttaa  atctactct  ctctgccta  aaggaataa  actatcact  5100
tttgtcata  cttcaacat  cacattaaa  tccaactcc  taatctcca  aaccatccc  5160
attaccatt  tagtttttg  agcctgcga  gtagcagta  gtttagcct  actagtaaa  5220
atttcaaat  cccacggaa  agactacgt  caaaacctc  accttctac  atgttaaaa  5280
tcattttcc  atctatcat  ctcctccca  taacatgac  ctcagccaa  aaaaaaatc  5340
gaaccaatg  cacctccta  agctttcta  tgagcctat  aagcttatc  ctcctatga  5400
aaaatgacg  aaattacct  aatttctca  ttatattct  ctccgatcc  ttatccacc  5460
cactaatca  tctaacaac  tgactcctc  cactaataa  gctcgctag  caaaatcac  5520
taaaaaaag  aaatataat  catcaaaaa  tttacatct  aatacttat  agcctccaa  5580
ttttactca  cataacatt  tccgcaaca  aactaattt  attttatat  ctgttcgaa  5640
ccactctaa  cccaacact  attatcatt  cacgatgag  caaccaaac  gaacgctta  5700
atgcaggaa  ttatttcct  ttttataca  taattggct  catcccact  ttaattgcc  5760
tcatttcaa  ccaaaactc  ataggaaca  tcaacttcc  aatcctctc  ctcacaaca  5820
accccctac  ctcaacatg  tccaacacc  ttctatgac  agcatgtat  atagcattt  5880
taatcaaaa  accattata  ggagtccat  tatgattac  aaaagccca  gtagaagct  5940
caattgcag  ctctataat  ttagcagca  ttctcctaa  gctaggggg  tatgggata  6000
tacgagttt  catcattct  gacccccta  caaaatctt  agcctaccc  ttcatcatc  6060
tctcattat  aggcataat  ataactagc  cggtctgcc  acgccaaac  gatctaaaa  6120
cattaattg  ttactcatc  gtaagccat  tagccctag  catcacagc  attataatc  6180
agacaccat  aagcttcat  ggagctaca  tactaataa  cgcccacgg  ttaacctca  6240
cactcttat  ctgcctagc  aacaccaac  acgaacgaa  tcacagccg  actataatt  6300
tagctcgag  attacaaat  atcttttca  tgatagcaa  atgatgatt  ttagcaagc  6360
tagccaacc  agcactacc  cccctaatt  acctcatag  cgagttatt  attgttata  6420
caacatttt  ctgatcgaa  ccctctatc  tccttatag  aactaacat  gtcactaca  6480
gaatatact  aatatatat  attatcaca  cccaacgag  aaaactaac  agccacata  6540
acaacctcc  accttccca  acacgagaa  taacactca  agctctaca  attattccc  6600
tcatactat  aacaatcaa  cctaaactc  tcacaggcc  aacaatatg  agatatagt  6660
tacaaaaaa  attagactg  gaatctaac  acaggaaat  aaattcctt  tttaccaag  6720
aagtatgca  gaactgcta  ttcatgcac  catacctaa  acatatggc  ttcttactt  6780
tataggata  aagtaatcc  ttggtctta  gaaccaaaa  ccttggtgc  actccaaat  6840
aaagtaata  6849



<210> 2389
<211> 1912
<212> DNA
<213> Rattus norvegicus
<308> J01436
<400> 2389

ccggtactc  tcagtagcc  tagcagttg  atacccaaa  acaaccaac  tcccaccca  60
ataaattaa  aatactatt  aacctaaaa  cgaaccccc  aaccctaaa  ctattaagc  120
cccaataca  ccactaaca  tcaatccaa  cccaccata  ataggtgaa  gcttcaacg  180
caaccctag  caaccagtc  aaaacagta  acttaaaat  aacatataa  ttgtcatta  240
ttctacaca  catttaact  tgactaatg  catgaaaaa  catcgttgt  attcaacta  300
agaaacacc  aatgacaaa  atccgaaaa  ctcaccccc  attcaaaat  atcaaccac  360
cctttatcg  cctccccgc  ccatctaac  tctcatcat  atgaaactt  ggttctcta  420
taggagtat  cctcatagt  caaatcctc  caggcttat  cctagcaat  cactacacg  480
ctgatacca  aacagcatt  tcatcagtc  cccacatct  ccgagacgt  aactacggc  540
gactaatcc  atacctaca  gccaacggc  cctcaatat  tttcatctg  ctattcctc  600
atgtgggac  aggactata  tatggatcc  acactttcc  agaaacctg  aacattggg  660
tcatcctac  atttgcagt  atagcaact  cattcatgg  ctatgtact  ccatgagga  720
aaatatcat  ctgaggagc  acagtaatt  caaacctat  atcagctac  ccttacatt  780
ggactaccc  agtcgaatg  atctgagga  gcttctcag  agacaaagc  accctaaca  840
gcttcttcg  attccactt  atcctccca  tcattatcg  cgcccttgc  attgtacat  900
ttcttttcc  ccacgaaac  ggatcaaat  accccacag  attaaactc  gacgcagac  960
aaatcccat  ccatccata  tatacaatt  aagacctcc  aggtgtatt  atattacta  1020
tattcctaa  aaccctagt  ctattcttc  cagacctac  aggagaccc  gacaattat  1080
cacccgcta  ccccctcaa  accccaccc  acatcaaac  agaatgata  tttctcttt  1140
cctacgcta  tctacgctc  attcccaac  aactaggag  ggtcgtagc  ctaatctta  1200
caatcctaa  cttagcctt  ctaccattc  tgcatacct  aaaacaacg  agcttaaca  1260
tccgcccaa  cacccaaat  ctttactga  tcctagtag  caacctcct  gtcttaaca  1320
gaatcggag  ccaaccagt  gaacaccca  ttatcatta  tggtcaact  gcctccatc  1380
gctattttt  aattatcct  attctcata  caatctctg  aattgttga  gacaaaatg  1440
taaaatgaa  ttaatgtcc  gatagtata  aaattactc  ggtcttgta  accaaaaat  1500
aagagtcag  cttctcagg  caatcaaga  gaaggaact  cctccccac  atcaacacc  1560
aaagctgat  ttctactta  actacttct  gtcagtaca  aaaatgata  ggacattaa  1620
aaacattta  gtatatcgt  cattaaatt  ttttcccaa  catataagc  tgtaatata  1680
atctaatga  ttaggacat  gatttaaac  caactataa  ttcacaaca  catgtctat  1740
ctcaaatac  ttagataat  tctattaga  atatctgtg  tattagaca  gcaccatta  1800
gtcataaac  tttctcttc  atatgacta  ccctgtccc  aattggtct  tatttctac  1860
atcctccgt  aaatcaaca  cccgcccac  cgtccccct  ttctcgctc  gg  1912



<210> 2390
<211> 380
<212> PRT
<213> Rattus norvegicus
<308> AAA99907
<400> 2390

Met Thr Asn Ile Arg Lys Ser His Pro Leu Phe Lys Ile Ile Asn His 
  1               5                  10                  15
Ser Phe Ile Asp Leu Pro Ala Pro Ser Asn Ile Ser Ser Trp Trp Asn 
             20                  25                  30
Phe Gly Ser Leu Leu Gly Val Cys Leu Met Val Gln Ile Leu Thr Gly 
         35                  40                  45
Leu Phe Leu Ala Met His Tyr Thr Ser Asp Thr Met Thr Ala Phe Ser 
     50                  55                  60
Ser Val Thr His Ile Cys Arg Asp Val Asn Tyr Gly Trp Leu Ile Arg 
 65                  70                  75                  80
Tyr Leu His Ala Asn Gly Ala Ser Met Phe Phe Ile Cys Leu Phe Leu 
                 85                  90                  95
His Val Gly Arg Gly Leu Tyr Tyr Gly Ser Tyr Thr Phe Leu Glu Thr 
             100                105                110
Trp Asn Ile Gly Ile Ile Leu Leu Phe Ala Val Met Ala Thr Ala Phe 
         115                120                125
Met Gly Tyr Val Leu Pro Trp Gly Gln Met Ser Phe Trp Gly Ala Thr 
     130                135                140
Val Ile Thr Asn Leu Leu Ser Ala Ile Pro Tyr Ile Gly Thr Thr Leu 
 145                150                155                160
Val Glu Trp Ile Trp Gly Gly Phe Ser Val Asp Lys Ala Thr Leu Thr 
                 165                170                175
Arg Phe Phe Ala Phe His Phe Ile Leu Pro Phe Ile Ile Ala Ala Leu 
             180                185                190
Ala Ile Val His Leu Leu Phe Leu His Glu Thr Gly Ser Asn Asn Pro 
         195                200                205
Thr Gly Leu Asn Ser Asp Ala Asp Lys Ile Pro Phe His Pro Tyr Tyr 
     210                215                220
Thr Ile Lys Asp Leu Leu Gly Val Phe Met Leu Leu Leu Phe Leu Met 
 225                230                235                240
Thr Leu Val Leu Phe Phe Pro Asp Leu Leu Gly Asp Pro Asp Asn Tyr 
                 245                250                255
Thr Pro Ala Asn Pro Leu Asn Thr Pro Pro His Ile Lys Pro Glu Trp 
             260                265                270
Tyr Phe Leu Phe Ala Tyr Ala Ile Leu Arg Ser Ile Pro Asn Lys Leu 
         275                280                285
Gly Gly Val Val Ala Leu Ile Leu Ser Ile Leu Ile Leu Ala Phe Leu 
     290                295                300
Pro Phe Leu His Thr Ser Lys Gln Arg Ser Leu Thr Phe Arg Pro Ile 
 305                310                315                320
Thr Gln Ile Leu Tyr Trp Ile Leu Val Ala Asn Leu Leu Val Leu Thr 
                 325                330                335
Trp Ile Gly Gly Gln Pro Val Glu His Pro Phe Ile Ile Ile Gly Gln 
             340                345                350
Leu Ala Ser Ile Ser Tyr Phe Ser Ile Ile Leu Ile Leu Met Pro Ile 
         355                360                365
Ser Gly Ile Val Glu Asp Lys Met Leu Lys Trp Asn 
     370                375                380



<210> 2391
<211> 2509
<212> DNA
<213> Rattus norvegicus
<308> J02596
<400> 2391

taaagagac  gatgaccta  agccccagg  ccacccatt  aacaggcct  gctcattcc  60
aagcccaga  atcaaggca  gggacaccc  cgcatggca  cttcgtgtc  agctttatt  120
gggacagca  gtttaggtg  ggtctgggg  gggataaag  catgagaat  tactttccc  180
ttagagcaa  cttcggagg  agcaggata  atggccaga  acatctgga  catggaggt  240
tcacggctc  agagttggt  ttgttagtt  gtcctcagg  ccagactcc  agaggccag  300
gaacttatc  gtgaacttg  tccagtagc  tttcaggga  ttgaagcga  tgtccatcc  360
gcccctggg  gttaaaaca  taataggtg  gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  420
gtgtgtgtg  gtgtgtgtg  gaaaagatc  cctgtgggc  gctagaccc  ggggtgcac  480
taggcctcc  ctggctccc  aagccacca  caccacctt  cctagcacc  ccctcagaa  540
cacctgcag  taccactca  ggtggagga  atggtaaag  ctaagaaaa  ccaccttca  600
cagagcccc  ttacctccc  tccaatctc  cttcaggcc  gaggcacca  ccactgggg  660
ggtggatac  aaggtcagc  tgcctttgt  gtccataga  acagtgtcc  tgaggtgtc  720
catccctgg  tctaagtgg  tggatcaag  gaggggtga  ctttctgtt  ggaaacatt  780
ccagagggc  tctaagctc  gtgatctag  ccaggttat  taactcttt  ccagctgcg  840
aggtagata  tacctctcc  caacctgtt  tgggcacag  gactgtcaa  atcttttgc  900
acataggca  tgatcaaat  tcacgtaaa  gattggcag  gtaatgttt  atcacgggc  960
agatgcctc  cttaggttg  gcccaggga  ggaaacagg  cagaacccc  aacccgtaa  1020
gctcaacct  ccaacttcc  tgtaatcag  gcaggaagg  ctcccagag  acaccctag  1080
ccctgtgct  aaagaagaa  acctgcagg  aggctgaac  ctcctcagg  tgctctgag  1140
agaagcaga  gagatagaa  aagtctgct  gcactgcct  tcatcttag  cacagtccc  1200
agcaaaggc  ccgtgagag  ctggatgct  agacgggcc  aagaccctg  taaacttgg  1260
gggccacag  ctccgtgtc  agggcctca  caccagggc  ggaggggcg  ggaccagga  1320
aggaggtcc  tgtgcatac  tggccacca  agctatatc  gactcctgc  tgctgctta  1380
tgcatcctg  accgtcttg  aggcttgtt  catgtagcc  tgcatagag  ccagcagca  1440
ggatccctc  ccctcatca  ctcctgcaa  agagcagag  tgagccagg  cagccctca  1500
ctcttgccc  gccatcgct  ttcagggta  ggtccccag  ccagctccc  cagaaatcc  1560
agccccact  ccaccagct  acgggcaga  gccaggaga  ccacgaggg  cacgatgag  1620
agcattcgg  gctgcatgg  acctgtgca  ctgcgggag  ccatcttgt  agagggtat  1680
gtggatctc  acatctaag  ccttccctg  agaacacca  ggcccctct  tcatgaatc  1740
ccaagcctt  ctcctactg  tatcagctc  cggagagag  actaagaag  cccagaccc  1800
ccccaaggg  ctggaaggt  gaatgtggg  atcctctgc  aagcagaac  tctacccag  1860
ctctgcccc  atatatgga  aaacaacag  tttcttttt  tctctaggc  tcaggcttt  1920
cagtctggg  taggcacgg  tatcaaagg  ttctaatag  tcagagcaa  acgaacaag  1980
ggcagcatg  cccagttcc  aatcagctc  gccactacc  agtgcaagg  ttttttgcc  2040
agtggcctc  ctttcctca  cttctagcc  cccccaccc  ccaggatac  caagggctg  2100
aggccgtga  ttccaagca  tctgtaggc  agctggctg  gtggccaga  cgtcttctc  2160
ctgtctcct  cctcccttc  tctcctccc  aggggcatt  cctggagta  ctagctgct  2220
ctagggata  aactgggca  gcaagccgg  acgctctga  ctgttttat  ttggctcca  2280
gatgggaca  cgggcacag  aggcccagt  agctggtca  aggtcacct  ctgaacagt  2340
cagaccaga  cccgaggca  ggaggccat  cagccagct  ccagaggag  tgagaaatc  2400
ctcagagat  gcccacacc  ttcacttcc  cctccgcag  caagagatc  gctactgac  2460
tgcctcgat  agactggtg  gacaggaaa  gactcaggg  acaagcctt  2509



<210> 2392
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> AAA40746
<400> 2392

Met Gln Pro Arg Met Leu Leu Ile Val Ala Leu Val Ala Leu Leu Ala 
  1               5                  10                  15
Ser Ala Arg Ala Asp Glu Gly Glu Gly Ser Leu Leu Leu Gly Ser Met 
             20                  25                  30
Gln Gly Tyr Met Glu Gln Ala Ser Lys Thr Val Gln Asp Ala Leu Ser 
         35                  40                  45
Ser Met Gln Glu Ser Asp Ile Ala Val Val Ala Ser Arg Gly Trp Met 
     50                  55                  60
Asp Asn Arg Phe Lys Ser Leu Lys Gly Tyr Trp Ser Lys Phe Thr Asp 
 65                  70                  75                  80
Lys Phe Thr Gly Leu Trp Glu Ser Gly Pro Glu Asp Gln Leu Thr Thr 
                 85                  90                  95
Pro Thr Leu Glu Pro 
             100



<210> 2393
<211> 533
<212> DNA
<213> Homo sapiens
<308> NM_000040
<400> 2393

tgctcagtt  atccctaga  gcagctgct  caggaacag  ggtgccatg  agccccggg  60
actccttgt  gttgccctc  tggcgctcc  ggcctctgc  cgagcttca  aggccgagg  120
tgcctccct  ctcagcttc  tgcagggtt  catgaagca  gccaccaag  ccgccaagg  180
tgcactgag  agcgtgcag  agtcccagg  ggcccagca  gccaggggc  gggtgaccg  240
tggcttcag  tccctgaaa  actactgga  caccgttaa  gacaagttc  ctgagttct  300
ggatttgga  cctgaggtc  gaccaactt  agccgtggc  gcctgagac  tcaataccc  360
aagtccacc  gcctatcca  cctgcgagc  ccttgggtc  tgcaatctc  agggctgcc  420
ctgtaggtt  cttaaaagg  acagtattc  cagtgctct  ctaccccac  tcatgcctg  480
cccccctcc  ggcatgctg  cctcccaat  aagctggac  agaagctgc  atg  533



<210> 2394
<211> 99
<212> PRT
<213> Homo sapiens
<308> P02656
<400> 2394

Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu Leu Ala 
  1               5                  10                  15
Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met 
             20                  25                  30
Gln Gly Tyr Met Lys His Ala Thr Lys Thr Ala Lys Asp Ala Leu Ser 
         35                  40                  45
Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp Val Thr 
     50                  55                  60
Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys Asp Lys 
 65                  70                  75                  80
Phe Ser Glu Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Thr Ser Ala 
                 85                  90                  95
Val Ala Ala 
             100



<210> 2395
<211> 1927
<212> DNA
<213> Rattus norvegicus
<308> J02612
<400> 2395

gaggaaacc  ggaattcag  tggtggctg  gggtggctg  ctgaaaaac  gacttccag  60
tttcttact  ttccacaag  gccctcatc  cgtgcgcag  tctctaacc  tactctctg  120
aaggatggc  tgccttctt  ctgctgctc  acttcctgc  ggctttctc  tcttagtgc  180
ctggggctc  gttctaggt  acaagctgc  ggtggtccc  caggatggc  gccactggc  240
tagcatgaa  gagatagtg  agcacctca  tgaacgcgg  cacgacatt  tggtgctag  300
gccagaagt  aatttgctt  tgggagaat  caaatacta  aggaggaaa  gctttccgg  360
cccctacaa  ctagaagag  tacggaccc  ctatcgctc  tttgggaac  accactttg  420
tgccagttc  cccctgatg  ctcctctaa  agagtacag  aacaacatg  ttgtcattg  480
catgtgctt  ttcagctgc  agagcctcc  gaaggactc  gccaccctc  gcttcctca  540
ggagaacca  tttgatgct  tgttcacag  cccggccat  ccctgtggt  tgatcctgg  600
tgagtatct  aagctgcct  ccatctacc  cttcagagg  ttcccatgc  ctctggagc  660
cattggtca  agcccaagc  ccgtatcct  tgttcccag  ttctacacc  aattctcag  720
ccacatgac  tttccccaa  ggctggcca  cttcattgc  aacatcttg  agaactacc  780
ttatcattg  ctgtactca  agtatgaga  ccttgcctc  gacctcctc  agagagatg  840
gtccctacc  gccttacac  agaactctc  gtggctgtt  cggtatgat  ttgtgttcg  900
atacccccg  ccagtcatg  ccaacatga  cttcattgg  gggaccaac  gcaagaaga  960
ggggaacct  tctcaggaa  ttgaagcct  tgtcaacgc  tccggagaa  atggcatcg  1020
ggttttctc  ttgggatcc  tggtctcag  gattccaga  aagaaagcg  tggaaatcg  1080
tgaggcttt  ggcagaatt  ctcagacgc  cctgtggcg  tacaccgga  ctagaccat  1140
gaaccttgc  aagaacact  ttcttgtca  atggctacc  caaaacgat  tgcttggtc  1200
tccaaaggc  cgggcgttc  tcacacact  cggttccca  ggtatttat  aaggaatat  1260
caatggggt  ccaatggtg  tgatgccct  gtttggtga  cagatggac  acgccaagc  1320
catggaaac  cggggagct  gggtgaccc  gaatgtcct  gaaatgact  ccgatgatt  1380
ggaaaacgc  cttaaaact  tcatcaata  caagagtta  aaggagaac  tcatgcgcc  1440
ctccagcct  cacaaggac  gtcctatcg  gcctctgga  ctggctgtg  tctgggtgg  1500
gtacgtgat  aggcacaag  gggcgccac  cctgcgccc  gccgcccac  acctcacct  1560
gtaccagta  cactccttg  acgtgattg  ctttctcct  gccatcgtg  tgacggtgg  1620
cttcattgt  tataaaagt  gtgcctatg  ctgccggaa  tgctttggg  gaaagggtc  1680
agtgaagaa  tcacacaaa  ccaagaccc  ctgagaagt  gcaggaagt  aaggagaag  1740
attagtccc  tatccaatc  gttgaaact  ggaaacaag  gttaaatcc  tgttgcttt  1800
attagggaa  taattcacc  tacactata  acccagaac  ttttttttt  tttttcttt  1860
tttcggagc  ggggaccga  cccagaaca  cttcttttt  taaataaaa  caacccaat  1920
gccggcc  1927



<210> 2396
<211> 529
<212> PRT
<213> Rattus norvegicus
<308> P08430
<400> 2396

Met Ala Cys Leu Leu Pro Ala Ala Arg Leu Pro Ala Gly Phe Leu Phe 
  1               5                  10                  15
Leu Val Leu Trp Gly Ser Val Leu Gly Asp Lys Leu Leu Val Val Pro 
             20                  25                  30
Gln Asp Gly Ser His Trp Leu Ser Met Lys Glu Ile Val Glu His Leu 
         35                  40                  45
Ser Glu Arg Gly His Asp Ile Val Val Leu Val Pro Glu Val Asn Leu 
     50                  55                  60
Leu Leu Gly Glu Ser Lys Tyr Tyr Arg Arg Lys Ser Phe Pro Val Pro 
 65                  70                  75                  80
Tyr Asn Leu Glu Glu Leu Arg Thr Arg Tyr Arg Ser Phe Gly Asn Asn 
                 85                  90                  95
His Phe Ala Ala Ser Ser Pro Leu Met Ala Pro Leu Arg Glu Tyr Arg 
             100                105                110
Asn Asn Met Ile Val Ile Asp Met Cys Phe Phe Ser Cys Gln Ser Leu 
         115                120                125
Leu Lys Asp Ser Ala Thr Leu Ser Phe Leu Arg Glu Asn Gln Phe Asp 
     130                135                140
Ala Leu Phe Thr Asp Pro Ala Met Pro Cys Gly Val Ile Leu Ala Glu 
 145                150                155                160
Tyr Leu Lys Leu Pro Ser Ile Tyr Leu Phe Arg Gly Phe Pro Cys Ser 
                 165                170                175
Leu Glu His Ile Gly Gln Ser Pro Ser Pro Val Ser Tyr Val Pro Arg 
             180                185                190
Phe Tyr Thr Lys Phe Ser Asp His Met Thr Phe Pro Gln Arg Leu Ala 
         195                200                205
Asn Phe Ile Ala Asn Ile Leu Glu Asn Tyr Leu Tyr His Cys Leu Tyr 
     210                215                220
Ser Lys Tyr Glu Ile Leu Ala Ser Asp Leu Leu Lys Arg Asp Val Ser 
 225                230                235                240
Leu Pro Ala Leu His Gln Asn Ser Leu Trp Leu Leu Arg Tyr Asp Phe 
                 245                250                255
Val Phe Glu Tyr Pro Arg Pro Val Met Pro Asn Met Ile Phe Ile Gly 
             260                265                270
Gly Thr Asn Cys Lys Lys Lys Gly Asn Leu Ser Gln Glu Phe Glu Ala 
         275                280                285
Tyr Val Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu Gly 
     290                295                300
Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Glu Ile Ala Glu 
 305                310                315                320
Ala Leu Gly Arg Ile Pro Gln Thr Leu Leu Trp Arg Tyr Thr Gly Thr 
                 325                330                335
Arg Pro Ser Asn Leu Ala Lys Asn Thr Ile Leu Val Lys Trp Leu Pro 
             340                345                350
Gln Asn Asp Leu Leu Gly His Pro Lys Ala Arg Ala Phe Ile Thr His 
         355                360                365
Ser Gly Ser His Gly Ile Tyr Glu Gly Ile Cys Asn Gly Val Pro Met 
     370                375                380
Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg Met 
 385                390                395                400
Glu Thr Arg Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr Ala 
                 405                410                415
Asp Asp Leu Glu Asn Ala Leu Lys Thr Val Ile Asn Asn Lys Ser Tyr 
             420                425                430
Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro Ile 
         435                440                445
Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Tyr Val Met Arg His 
     450                455                460
Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp Tyr 
 465                470                475                480
Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Ile Val Leu 
                 485                490                495
Thr Val Val Phe Ile Val Tyr Lys Ser Cys Ala Tyr Gly Cys Arg Lys 
             500                505                510
Cys Phe Gly Gly Lys Gly Arg Val Lys Lys Ser His Lys Ser Lys Thr 
         515                520                525
His 
     530



<210> 2397
<211> 367
<212> DNA
<213> Homo sapiens
<308> AV683870
<400> 2397

cgaaactgt  tttgtgttt  gttacaagg  gaacatcat  cgcctctcc  gccttcaca  60
ggaccgccc  gtggagccg  tggacctgg  cgtgttctg  gtggagttt  tgatgaggc  120
caagggcgc  ccacacctg  gccccgcag  ccacgacct  acctggtac  agtaccatt  180
cttggacgt  attggtttc  tcttggctg  cgtgctgac  gtggccttc  tcaccttta  240
atgttgtgc  tatggctac  ggaaatgct  ggggaaaaa  gggcgagtt  agaaagccc  300
caaatccaa  acccattga  aagtgggtg  gaaataagg  ttttgccat  ccctagtct  360
tcccttg  367



<210> 2398
<211> 534
<212> PRT
<213> Homo sapiens
<308> P22310
<400> 2398

Met Ala Arg Gly Leu Gln Val Pro Leu Pro Arg Leu Ala Thr Gly Leu 
  1               5                  10                  15
Leu Leu Leu Leu Ser Val Gln Pro Trp Ala Glu Ser Gly Lys Val Leu 
             20                  25                  30
Val Val Pro Thr Asp Gly Ser Pro Trp Leu Ser Met Arg Glu Ala Leu 
         35                  40                  45
Arg Glu Leu His Ala Arg Gly His Gln Ala Val Val Leu Thr Pro Glu 
     50                  55                  60
Val Asn Met His Ile Lys Glu Glu Lys Phe Phe Thr Leu Thr Ala Tyr 
 65                  70                  75                  80
Ala Val Pro Trp Thr Gln Lys Glu Phe Asp Arg Val Thr Leu Gly Tyr 
                 85                  90                  95
Thr Gln Gly Phe Phe Glu Thr Glu His Leu Leu Lys Arg Tyr Ser Arg 
             100                105                110
Ser Met Ala Ile Met Asn Asn Val Ser Leu Ala Leu His Arg Cys Cys 
         115                120                125
Val Glu Leu Leu His Asn Glu Ala Leu Ile Arg His Leu Asn Ala Thr 
     130                135                140
Ser Phe Asp Val Val Leu Thr Asp Pro Val Asn Leu Cys Gly Ala Val 
 145                150                155                160
Leu Ala Lys Tyr Leu Ser Ile Pro Ala Val Phe Phe Trp Arg Tyr Ile 
                 165                170                175
Pro Cys Asp Leu Asp Phe Lys Gly Thr Gln Cys Pro Asn Pro Ser Ser 
             180                185                190
Tyr Ile Pro Lys Leu Leu Thr Thr Asn Ser Asp His Met Thr Phe Leu 
         195                200                205
Gln Arg Val Lys Asn Met Leu Tyr Pro Leu Ala Leu Ser Tyr Ile Cys 
     210                215                220
His Thr Phe Ser Ala Pro Tyr Ala Ser Leu Ala Ser Glu Leu Phe Gln 
 225                230                235                240
Arg Glu Val Ser Val Val Asp Leu Val Ser Tyr Ala Ser Val Trp Leu 
                 245                250                255
Phe Arg Gly Asp Phe Val Met Asp Tyr Pro Arg Pro Ile Met Pro Asn 
             260                265                270
Met Val Phe Ile Gly Gly Ile Asn Cys Ala Asn Gly Lys Pro Leu Ser 
         275                280                285
Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val 
     290                295                300
Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala 
 305                310                315                320
Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp 
                 325                330                335
Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu 
             340                345                350
Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg 
         355                360                365
Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys 
     370                375                380
Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp 
 385                390                395                400
Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val 
                 405                410                415
Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile 
             420                425                430
Asn Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His 
         435                440                445
Lys Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu 
     450                455                460
Phe Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His 
 465                470                475                480
Asp Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu 
                 485                490                495
Leu Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala 
             500                505                510
Tyr Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala 
         515                520                525
His Lys Ser Lys Thr His 
     530



<210> 2399
<211> 1687
<212> DNA
<213> Rattus norvegicus
<308> J02669
<400> 2399

tcaatcctc  ctggccact  tgctggaca  aggactgct  ctggtggtc  tattggcct  60
cctgagcgt  atgctcttg  tgtccctct  gcagcagaa  atcaggggg  gattgcctc  120
aggacccac  cctttgcct  tcattggaa  ttatctgca  ctgaataca  aagacgtat  180
cagttccat  acacagctc  gtgagcgct  tggtcctgt  ttcaccatc  accttgggc  240
tcgccgggt  gtggtgctt  atggatacg  tgcagtcaa  gaggctttg  tggaccaag  300
tgaggagtt  agtggacga  gcgaacagg  tacctacaa  acactcttc  aaggctatg  360
cgtggcatt  agcagtggg  agcgggcaa  acaactcag  cgcctctct  tagccacat  420
gagagattt  ggtgtgggc  agcgtggtg  agaggagcg  atcctggag  aggcaggct  480
tttgatcaa  atgttgcag  gcacttgtg  agcccccat  gaccccacc  tctacctga  540
caaaacagt  tccaatgtt  ttagctcca  tgtcttcgg  gaacgcttc  actatgagg  600
cacggagtt  ctgtcactg  tgcagatga  gggtcaaat  aacagattt  cagcttcac  660
cacagggca  ctctatgac  tgttccatt  agtgatgaa  tacctgcct  gaccacagc  720
acagatcat  aaggttact  agaaactgg  agacttcat  atagagaaa  tgaggcaga  780
ccatagtac  ctggacccc  attccccaa  gaacttcat  gactccttt  tcatccgca  840
gcaagagga  aaaaatggc  attcagagt  ccacatgaa  aacctagtg  tgacaacac  900
aagcctctt  tttgctggg  ctgagacag  cagctccac  ctacgctac  gcttccttc  960
actcatgaa  catccagat  tggaggcca  ggtccatga  gaaattgag  aggtgatcg  1020
caggaaccg  cagcctcag  atgaggacc  catgaagat  ccctacacc  aggctgtga  1080
caatgagat  caaagattt  ctaacttgg  tcccttggg  attcctcga  ggattatca  1140
gaacacaac  ttccgtggc  tcttcctcc  caaggccac  gatgtgttc  ctatattag  1200
ttctctgat  acagaccca  agttcttcc  tagccccaa  gacttcgac  cccagaact  1260
cctggatga  aagggacag  tgaagaaaa  tgctgcttt  ctccctttc  ccactggga  1320
gcgattctg  ttgggagat  gcctggcta  gatggagct  ttcctgctg  tcaccacta  1380
tttacagaa  ttccgtttc  agttcccaa  gaaactaga  gacatcaac  agtccccca  1440
acccttggg  tttaccagg  tcataccaa  gtacaccat  agcttcatg  ccatctgat  1500
ctgagttga  tcaaggtgg  gcaagaggg  gagagagcc  gaagtgggg  cagggtgca  1560
gtggagaga  caggggagg  gaagatgag  gttaagaag  gaccacacc  atggaagaa  1620
cacaaaaga  ttctcactt  ggtaaaatt  taacagtcc  aataaaaag  aagaaatac  1680
cagtcgg  1687



<210> 2400
<211> 492
<212> PRT
<213> Rattus norvegicus
<308> P11711
<400> 2400

Met Leu Asp Thr Gly Leu Leu Leu Val Val Ile Leu Ala Ser Leu Ser 
  1               5                  10                  15
Val Met Leu Leu Val Ser Leu Trp Gln Gln Lys Ile Arg Gly Arg Leu 
             20                  25                  30
Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln Leu 
         35                  40                  45
Asn Thr Lys Asp Val Tyr Ser Ser Ile Thr Gln Leu Ser Glu Arg Tyr 
     50                  55                  60
Gly Pro Val Phe Thr Ile His Leu Gly Pro Arg Arg Val Val Val Leu 
 65                  70                  75                  80
Tyr Gly Tyr Asp Ala Val Lys Glu Ala Leu Val Asp Gln Ala Glu Glu 
                 85                  90                  95
Phe Ser Gly Arg Gly Glu Gln Ala Thr Tyr Asn Thr Leu Phe Lys Gly 
             100                105                110
Tyr Gly Val Ala Phe Ser Ser Gly Glu Arg Ala Lys Gln Leu Arg Arg 
         115                120                125
Leu Ser Ile Ala Thr Leu Arg Asp Phe Gly Val Gly Lys Arg Gly Val 
     130                135                140
Glu Glu Arg Ile Leu Glu Glu Ala Gly Tyr Leu Ile Lys Met Leu Gln 
 145                150                155                160
Gly Thr Cys Gly Ala Pro Ile Asp Pro Thr Ile Tyr Leu Ser Lys Thr 
                 165                170                175
Val Ser Asn Val Ile Ser Ser Ile Val Phe Gly Glu Arg Phe Asp Tyr 
             180                185                190
Glu Asp Thr Glu Phe Leu Ser Leu Leu Gln Met Met Gly Gln Met Asn 
         195                200                205
Arg Phe Ala Ala Ser Pro Thr Gly Gln Leu Tyr Asp Met Phe His Ser 
     210                215                220
Val Met Lys Tyr Leu Pro Gly Pro Gln Gln Gln Ile Ile Lys Val Thr 
 225                230                235                240
Gln Lys Leu Glu Asp Phe Met Ile Glu Lys Val Arg Gln Asn His Ser 
                 245                250                255
Thr Leu Asp Pro Asn Ser Pro Arg Asn Phe Ile Asp Ser Phe Leu Ile 
             260                265                270
Arg Met Gln Glu Glu Lys Asn Gly Asn Ser Glu Phe His Met Lys Asn 
         275                280                285
Leu Val Met Thr Thr Leu Ser Leu Phe Phe Ala Gly Ser Glu Thr Val 
     290                295                300
Ser Ser Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His Pro Asp 
 305                310                315                320
Val Glu Ala Lys Val His Glu Glu Ile Glu Gln Val Ile Gly Arg Asn 
                 325                330                335
Arg Gln Pro Gln Tyr Glu Asp His Met Lys Met Pro Tyr Thr Gln Ala 
             340                345                350
Val Ile Asn Glu Ile Gln Arg Phe Ser Asn Leu Ala Pro Leu Gly Ile 
         355                360                365
Pro Arg Arg Ile Ile Lys Asn Thr Thr Phe Arg Gly Phe Phe Leu Pro 
     370                375                380
Lys Ala Thr Asp Val Phe Pro Ile Leu Gly Ser Leu Met Thr Asp Pro 
 385                390                395                400
Lys Phe Phe Pro Ser Pro Lys Asp Phe Asp Pro Gln Asn Phe Leu Asp 
                 405                410                415
Asp Lys Gly Gln Leu Lys Lys Asn Ala Ala Phe Leu Pro Phe Ser Thr 
             420                425                430
Gly Lys Arg Phe Cys Leu Gly Asp Gly Leu Ala Lys Met Glu Leu Phe 
         435                440                445
Leu Leu Leu Thr Thr Ile Leu Gln Asn Phe Arg Phe Lys Phe Pro Met 
     450                455                460
Lys Leu Glu Asp Ile Asn Glu Ser Pro Lys Pro Leu Gly Phe Thr Arg 
 465                470                475                480
Ile Ile Pro Lys Tyr Thr Met Ser Phe Met Pro Ile 
                 485                490



<210> 2401
<211> 8778
<212> DNA
<213> Homo sapiens
<308> U22028
<400> 2401

tgggtccaa  caaaatcaa  gtcaattcc  tgggcccag  gctgggctg  tgggctttt  60
tgggagcac  tgctgggct  gctacacac  ccacctccc  gaaactcca  acccacagc  120
ctgggtctt  ctagcccca  gactttcaa  tccatatgc  tggaatccc  cgtcctgag  180
cccttaacc  tgcatcctc  acaacagaa  acccccaga  gcacagcca  acttccatc  240
caccctagt  aaacccaga  ctttggatt  ctctcccgt  gaatgccca  atccacaac  300
ttggggtgc  gtctcactc  cagatccca  atccaaaga  caggtgctc  cctgtgcaa  360
tattccaaa  tcctcagtt  cacagttta  ctgttgccc  ctcctaaat  cacaggccc  420
gcagcaacc  tcctgaagt  gcagagtta  actggagtt  ccctccctg  tcatcttgc  480
ctggggtcc  tctcctcct  ccttgctgg  tgtgtccta  gctgtgtgg  attcagggt  540
ggggtgtag  tgggaggtg  aatgaggtg  ttatataat  aaccacagt  catccctct  600
tttcaggca  tataaaggc  aaccacccc  gccatcacc  tctatcatc  catggccac  660
atgctggcc  cagggctgc  tctggtgac  ttgctggcc  gcctgactg  gatggtctt  720
atgtcagtc  ggcggcaga  gaagagcag  gggaagctg  ctccgggac  caccccatt  780
cccttcatt  gaaactacc  ccagctgaa  acagagcag  tgtacaact  cctcatgaa  840
gtgtcctaa  gcaggagat  ggtggcacg  ggtgggggc  gcccagttg  ctggggctt  900
gtggcaggg  attgaccag  gtggaccag  gtcttagga  agggagtct  ggagtttca  960
catcagggt  ctagcagga  agacaggat  ttgggatgt  cagctccct  actgtgaga  1020
cctgggggc  aagcatccc  gtacatgat  tctcagcgc  gggcccatt  agagtgggg  1080
ctgctccct  taaccactc  cacctgcct  caacagatc  gtgagcgct  tggccctgt  1140
ttcaccatt  acttggggc  ccggcgggt  gtggtgctg  gcggacatg  tgccgtcaa  1200
gaggctctg  tggaccagg  tgaggagtt  agcgggcga  gcgagcagg  caccttcga  1260
tggctcttc  aaggctatg  tgagggggt  ccaagaggg  gaaggtggt  aggtggatg  1320
aatggtctc  gtgtcccca  ccttctccc  gactctcct  cccactgga  gatatggga  1380
agccccctg  ctggtcttc  ctccccatc  ccctacatc  gggactctc  ctgtgagtc  1440
cacacctgt  tccagcgcc  ctggcgtga  tcctccctg  ctctctctg  cccgtctcc  1500
ccttctctc  cactggagt  tcctcttac  cctctctct  catctctga  gacatccgg  1560
gtttctgtt  accagccct  gtcctctgt  ttcatttgt  tttttgtcg  tctcggctt  1620
tgtgcttct  cgtgtttct  ctctctctg  ttccctctc  cacttcttc  tctgtctta  1680
gatttcagg  tattcctac  tccacatct  cagctccca  ctcctggta  ttgtctgtc  1740
tccttcccg  tcctctctg  ttctgtctc  atatttttc  ctctcttct  cagttcaga  1800
taagaatct  tcaccattt  tatttcctc  tcccagatc  ccccatatc  cacttcccc  1860
ccctccatc  ctctctttc  ctccccact  ccttccctt  ctccatgga  tatccccgt  1920
tccctctgt  tctctgcat  tgtctgtct  gcctttctg  ttctcttct  attctctta  1980
tctttctac  cggactctc  ctctctctc  ctctctctc  ctctctctc  ctctctctc  2040
ctctctctc  ctctctcgt  ctctcgtgt  tctctgact  agagtgtag  tctcctggg  2100
actcgcgct  aatccatct  tctcccaca  cactccctc  ctacaccac  cttggggag  2160
cccttggaa  tggtccgct  ctgctacca  caccccctg  cctctctcc  cccccgcgt  2220
cacctcccc  ggcgtggcg  tcagcaacg  ggagcgcgc  aagcagctc  ggcgcttct  2280
catcgccac  ctaaggggt  ttggcgtgg  caagcgcgg  atcgaggaa  gcatccagg  2340
ggaggcggg  ttcctcatc  acgccctcc  gggcacgca  ggtgagtag  ggaccccga  2400
tgcgagggc  ggaacccgc  ctttctgcc  ggggatggg  actaggtgg  gaaaggggc  2460
cgcacttcc  gccctggag  ctggcgctg  gattcggct  aacagggcc  tgcctcctg  2520
aattctgac  ctcctcaga  ctctgagtt  actctctcc  caacccccc  tctcccgcc  2580
cacctgtag  cgccaatat  gatcccacc  tcttcctga  ccgcacagt  tccaatgtc  2640
tcagctcca  tgtctttgg  gaccgcttt  actatgagg  caaagagtt  ctgtcactg  2700
tgcgcatga  gctgggaag  ttccagttc  cgggaacct  cacggggca  gtaactgga  2760
gcagcccgc  agtgacgcc  ctaccacaa  ctgccaact  ctcccctac  tggagacag  2820
tgccccaaa  tcccacccc  ctccagaca  tgtcccctc  aaatcagtc  ccgatattg  2880
acaactgga  ggttggacc  gaacccagg  gggatgccc  atacccagt  tccaaggac  2940
cctggatag  tcaacagat  atccccaaa  cagagcctg  tggcaggat  cataccctc  3000
gctcagctc  ctcacctgg  cacatgttc  catccccat  ttaccgtaa  ttgtaacag  3060
tgctcccta  ccagttctt  tgaatattt  acacctgga  aagtgactg  gtcaacccg  3120
ctcctgcat  cctgaacac  tggtgctgc  aaatccagg  catcataat  atttcacat  3180
tacacaaat  tcacagatt  gcccactgg  aatatctgg  caagggccc  ctacttcac  3240
cacttaaat  cctgaaaac  tggacaggt  ccctaacca  taccctaaa  acataaata  3300
ctagataga  tattccctg  cacccaaat  agtgttccc  aaccctttc  aatcacaca  3360
cttacagag  tgctcccag  gcatcccac  tggataggt  aacacctca  caggtatcc  3420
ctccacttc  gcatcttca  cagccccac  ttatacctg  gcacctgaa  aaaagcccc  3480
aatccagac  cagtaagta  ctggacagc  gtctccaac  aagtccact  gaatgccta  3540
atacctaga  aggtgccac  cacctcata  cagccccac  tgaagagct  aacacctgg  3600
caggtgtct  ccaactcaa  ttcacttga  tatctgaac  cctagatgt  tgctccaat  3660
cagcctcat  tgcatacct  aaacctgga  atatgcctc  gttcttctc  cctaaatta  3720
tagaccgtg  ccctggcac  taatccacg  gaaaactta  atataagtt  ccatccaac  3780
ccactgaaa  acctaaaca  ctggacaga  gcctttaac  ccgttcctt  cttgctatg  3840
aacaaatcc  cattcccat  agctcctgc  ccgtgacag  tgtccttcc  ttcccatcc  3900
ctctctgca  ccccagctc  atgagatgt  ctcttcggt  atgaaacac  tgccaggac  3960
acagcaaca  gcctttaag  agctgcaag  gctggagga  ttcatcgcc  agaaggtgg  4020
gcacaacca  cgcacgctg  atcccaatt  cccacggga  ttcatcgac  cctttctca  4080
ccgcatgca  gaggtacat  ccagcagcc  gtgcaggca  gtgcaaagc  agggagagg  4140
aaatcagga  gggagtggg  tgggcagac  acacaggcc  attcaaatt  gccctcgtc  4200
taataatcc  tacaattgg  caggcgcgg  ggctcatga  ctgtaatcc  agcactttg  4260
gaggccgag  caggtggat  acctgaggt  aggagttcg  gaccagcct  gccaacatg  4320
tgaaacccc  tctctacta  aaatacaaa  atgagctag  tatggtggc  tgcgcctgt  4380
atcccagct  ctcaggagg  tgagacaga  gaatttgtt  gaatccggg  ggcagaggt  4440
gcagtgagc  gggatcatg  cactgcact  cggcctgag  gacagagca  gaccctgta  4500
aaaaaaaaa  aaaaaaaaa  aaaaattcc  gaaaacccc  attacatca  ccactgctg  4560
cccatctac  gagccctca  ccacaagga  gggttatgg  ggtggatta  attggaaag  4620
acttctcaa  aactaccgg  tgccaggaa  tgggttaag  gttttatga  agtccgcca  4680
ggaacactt  taacagttc  tgagggagg  tcactcatg  ccccagttg  acaaatgag  4740
aaactgagg  ccagagagt  taagtgtct  aactgaggt  acaacagtg  ggaagacca  4800
ggtccccct  gctcaaacc  tggtctctc  gagcctata  ctggtgctt  tagccacca  4860
gctctctaa  cgttcatgt  ctggttagc  gacacacct  tgtggacag  tgacctggc  4920
ttacattgc  gggtccccg  ctacctctg  atgtcagcc  cccatgtgg  aaggcttta  4980
gaagccaaa  ctcagggag  aaggatcaa  ggagggatt  ctccacagt  agtttcaag  5040
tttttaggg  agaaatagg  tgctgttgc  taaaattct  tgcttgtat  tcagaaaaa  5100
tcttttttt  tgactcttc  tcttgccat  tctgtacta  tttctcttc  tctcccctc  5160
tccttctct  tccaaatat  cctatcatt  aaaaagtaa  agactggga  acatggcaa  5220
accccgtct  tacaaaaaa  tggctaggc  tggtggtgc  tgcctgcgg  cccagctac  5280
aaggaggtt  aggtgggag  atatcttga  cccagggtg  gcagaggtt  caatgagcc  5340
atatcacag  cctgccctc  agcctgggt  acagaataa  accgtgtct  ccaaaaaaa  5400
aaagaatta  ttttttaac  gttaacaag  gagcctgca  agtcatgtg  atgtgcagt  5460
ccagctact  tggaggctg  gaccggagg  ttccttgaa  ccaggagtt  gagtccagc  5520
tgtgcaact  agcaagacc  agtctgcat  aaaaaaaaa  aaaccaact  acagctaag  5580
tgacaatta  aggatagat  atcagtgag  taaagaagg  gagaaggaa  agcattttg  5640
gcaaagcca  cagccaggg  aagggctgg  acctggagc  agtttggca  atctagggt  5700
cctctttcc  cctttggtc  ggaccaaag  gaggtagct  caaaggaaa  gccctagaa  5760
ggccccaag  gcatggaga  tgagcttgg  ctaaaccgc  ctctccctg  aggaggaga  5820
gaaccccaa  acagagttc  acttgaaga  cctggtgat  accaccctg  acctcttct  5880
tgcgggcac  gagaccgtg  gcaccaccc  gcgctacgg  ttcctgctg  tcatgaagc  5940
cccagaggt  gagggtaag  ctggaaagg  aggaaagtg  agggcccca  accctcaaa  6000
ctcccctga  cctggtgca  tgtacccac  tatcccaga  cccaggacc  tgagacgtg  6060
cttgctgtc  agagacagg  caatattca  ctgataggc  tcagctgag  ctcattagc  6120
attaaaata  tgaaaatgt  tgcactgat  ggtcagtca  tcctgtccc  agcccactg  6180
gtgtccgct  cctgctcct  tggatcatc  cctaagttc  tcccttgtc  taccctgtg  6240
ttctgacac  acctggttt  acagggatc  tgctgcaaa  aatgcgaat  ggtgatgtc  6300
tgttcttgt  tatgaatgg  cttaccctt  gtgtcagag  tggaagcta  gtcaaccgc  6360
gtgttttag  taggggggg  gatacatgc  ctgctctaa  acccctaga  agggtaaag  6420
tattcccct  ctccgccag  caaggtcca  gaggagatt  acagagtga  cggcaagaa  6480
cggcagccc  agtttgagg  ccgggccaa  atgccctac  cagaggcag  gatccacga  6540
atccaaaga  ttggagaca  gctccccat  ggtttggcc  acagggtca  caaggacac  6600
aagtttcgg  atttcttcc  ccctaaggt  ctgtctccc  tccaccacc  ccactcaga  6660
tacggggac  tccagcctc  ctctgtgtc  ccagaatcc  gcccccatt  gtgttctag  6720
ctctgtccc  ctccctcaa  cagtcaaaa  agacttccc  aaccaccac  tctgttcca  6780
ctttccact  agacagtcc  gagtcctgc  tctcgccag  ctctttgtg  caggagaat  6840
caccccatg  tcccaatct  cctgtctta  gaaacagaa  ccccctttc  attaggcct  6900
gtggcttag  gacacaaat  tcaggtccc  caaacaccc  ggctagtgg  acatggacc  6960
catgtctcc  aaacttcct  tctcagaga  atgaaactt  tatccccca  agctcctcc  7020
tcagaggtc  ccaactcct  catgtcgtg  cactccccg  acctggggg  ccctagagc  7080
ccctggagc  cctgtgtac  ttcaccaat  cccccaacc  ggctcataa  acacacctt  7140
ctcctccct  ccagggcac  gaagtgttc  ctatgctgg  ctccgagct  agagacccc  7200
ggttcttct  caaccccca  gactgcagt  cccagcact  cctggatga  aaggggcag  7260
ttaagaaga  tgatgcttt  gtgcccttt  ccatcggta  gagacactg  ttgctgcca  7320
gccacggct  acaccagca  gggcctctc  cacccacct  ccctctctg  ggtgtagcc  7380
ggtatttct  cagcttgga  gttcctgtt  gaatctacc  ttgagccgc  accagctga  7440
actccctta  ctgccaagc  cccaatacc  gcgcccagg  aaaagggaa  gaaacatct  7500
cccccatag  tttatttgt  tagggtcac  cagcagatt  ttcagctcc  tgaaaagga  7560
ataatggta  agcacagca  tcatatttg  aagtgtatc  ggggggtag  ggcatctaa  7620
cctcccatt  ctacacctg  catggatca  cccatctat  atggaggca  gacattatg  7680
ctttttcga  acccataga  ctgtataac  cagagtaaa  cctaatgta  actatggac  7740
ttggttagt  ataatatat  aatattggt  caccattgt  atatctctt  tagaaggaa  7800
ctgaagctc  gggaggatc  gagtctcct  tgaaagtct  tcaggccat  atattccca  7860
ccctcctcc  tagagagtg  agccggggg  cagtagggg  tgaggctgc  ctgagagtg  7920
gcttcacct  cacccctcc  gcctctcct  ctcaggaaa  cggtactgt  ttggagaag  7980
cctggccag  atggagctc  ttctcttct  caccaccat  atgcagaac  ttcgcttca  8040
gtcccctca  tcgcctaag  atatcgacg  gtcccccaa  cacgtgggc  ttgccacga  8100
cccacgaaa  tacaccatg  gcttcctgc  ccgctgagc  agggctgtg  tggtgcagg  8160
ctggtgggc  gggccaggg  aacggccgg  gcaggggcg  ggcttgtgg  aggggcggg  8220
ctaagaatg  gggcagtgg  ggaaggaag  ggagaggtg  ttagaggga  cagaagaaa  8280
agaaggggc  cagttcacc  tgatgatgt  cttcagagc  gtgatgaga  gaagggaaa  8340
cttacagta  gctacaaag  gtagtaata  tagcagctc  tatctcctg  acaagtccc  8400
ccctgtcag  tttgttcaa  aagcgttgc  cgctcacct  acttatttg  cacacacct  8460
taccaatgg  ggaaaagtc  tcattcccc  ttttacacg  gagaaaggt  cggctcaga  8520
agttgtctc  atctgaaaa  tcacaaaac  caagtgtcc  gaggatctt  gaacacaga  8580
ctgggccca  agccctcta  atcgatcct  accatagca  cccttcttc  cgtaaaata  8640
cttagtata  catcacatg  cctgaacac  cctgggccg  ggggttccc  agagacctg  8700
cgggcggct  ccctgccta  tctgtacac  cgcctactc  ggacgatcc  ggcaccagg  8760
tgtcacctg  gctcgcta  8778



<210> 2402
<211> 494
<212> PRT
<213> Homo sapiens
<308> Q16696
<400> 2402

Met Leu Ala Ser Gly Leu Leu Leu Val Thr Leu Leu Ala Cys Leu Thr 
  1               5                  10                  15
Val Met Val Leu Met Ser Val Trp Arg Gln Arg Lys Ser Arg Gly Lys 
             20                  25                  30
Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln 
         35                  40                  45
Leu Asn Thr Glu Gln Met Tyr Asn Ser Leu Met Lys Ile Ser Glu Arg 
     50                  55                  60
Tyr Gly Pro Val Phe Thr Ile His Leu Gly Pro Arg Arg Val Val Val 
 65                  70                  75                  80
Leu Cys Gly His Asp Ala Val Lys Glu Ala Leu Val Asp Gln Ala Glu 
                 85                  90                  95
Glu Phe Ser Gly Arg Gly Glu Gln Ala Thr Phe Asp Trp Leu Phe Lys 
             100                105                110
Gly Tyr Gly Val Ala Phe Ser Asn Gly Glu Arg Ala Lys Gln Leu Arg 
         115                120                125
Arg Phe Ser Ile Ala Thr Leu Arg Gly Phe Gly Val Gly Lys Arg Gly 
     130                135                140
Ile Glu Glu Arg Ile Gln Glu Glu Ala Gly Phe Leu Ile Asp Ala Leu 
 145                150                155                160
Arg Gly Thr His Gly Ala Asn Ile Asp Pro Thr Phe Phe Leu Ser Arg 
                 165                170                175
Thr Val Ser Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp 
             180                185                190
Tyr Glu Asp Lys Glu Phe Leu Ser Leu Leu Arg Met Met Leu Gly Arg 
         195                200                205
Phe Gln Phe Thr Gly Thr Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser 
     210                215                220
Ser Val Met Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Lys Glu 
 225                230                235                240
Leu Gln Gly Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln 
                 245                250                255
Arg Thr Leu Asp Pro Asn Ser Pro Arg Asp Phe Ile Asp Ser Phe Leu 
             260                265                270
Ile Arg Met Gln Glu Glu Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu 
         275                280                285
Lys Asn Leu Val Met Thr Thr Leu Asn Leu Phe Phe Ala Gly Thr Glu 
     290                295                300
Thr Val Ser Thr Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His 
 305                310                315                320
Pro Glu Val Glu Ala Lys Val His Glu Glu Ile Asp Arg Val Ile Gly 
                 325                330                335
Lys Asn Arg Gln Pro Lys Phe Glu Asp Arg Ala Lys Met Pro Tyr Thr 
             340                345                350
Glu Ala Val Ile His Glu Ile Gln Arg Phe Gly Asp Met Leu Pro Met 
         355                360                365
Gly Leu Ala His Arg Val Asn Lys Asp Thr Lys Phe Arg Asp Phe Phe 
     370                375                380
Leu Pro Lys Gly Thr Glu Val Phe Pro Met Leu Gly Ser Glu Leu Arg 
 385                390                395                400
Asp Pro Arg Phe Phe Ser Asn Pro Gln Asp Cys Ser Pro Gln His Phe 
                 405                410                415
Leu Asp Glu Lys Gly Gln Phe Lys Lys Ser Asp Ala Phe Val Pro Phe 
             420                425                430
Ser Ile Gly Lys Arg Tyr Cys Phe Gly Glu Gly Leu Ala Arg Met Glu 
         435                440                445
Leu Phe Leu Phe Phe Thr Thr Ile Met Gln Asn Phe Arg Phe Lys Ser 
     450                455                460
Pro Gln Ser Pro Lys Asp Ile Asp Val Ser Pro Lys His Val Gly Phe 
 465                470                475                480
Ala Thr Ile Pro Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg 
                 485                490



<210> 2403
<211> 8377
<212> DNA
<213> Rattus norvegicus
<308> J02722
<400> 2403

aagcttgct  ctaatttcc  aaatgttag  gttggtttt  ctggagaat  tcaggatta  60
caaaacaaa  acacaaaaa  tgaagtcct  gttgagatc  aaagtcact  tagagtagg  120
gagatggcc  ggtggttca  agtacttgc  gcccttaca  aggacctga  ttcagttcc  180
tacatgggc  gctcactac  ccctgtgac  cccagtcat  ggggaccca  tgccctctt  240
tttcttctc  ggcatctat  tgcacgtgg  atgaataca  acatacatt  acttgggtc  300
acagacaca  ataaaataa  taatatgtt  tcgttgttg  tgtcttttc  agacagggt  360
tctctgtgt  gccttggct  tcctggaac  ccctctgta  accaagctg  cctcaaact  420
acagagatg  gccagcctc  gcctcctgg  tgctaggct  aaaggcctg  ctgtaccat  480
actacctgg  aaacagtaa  tacttttta  agaggtatt  taagaagta  atactttta  540
caataacaa  aaaggacaa  tagaactac  gaggctttg  agaaccacc  agcatgttt  600
tgtattctc  gtcctgtac  aaaggtcca  ctcgccagg  attcggagg  taattgtcc  660
agtcctccc  tctaagctt  ggtgggtta  ctgccgtta  agatgtgtc  gagccatgt  720
tcctgactt  agtctccgg  actcaggca  caggaagtc  cagtgtggc  caggttcta  780
gagagcacc  aggaggcgc  agaggtggg  gctgcactc  atgagaccc  gggcagaaa  840
cttcatcct  cagctcaca  tccccgcct  taagactgg  gccatctat  ccccactgt  900
acacatggg  atgaacctt  gaaaagtca  tctaggcag  tgttagtaa  acaaacagg  960
ctatgtaca  aaaggattg  gaaaaccag  catccttag  gttccggga  ggtagactc  1020
agtatgtag  cttggggcc  ggatgggtc  atccctggg  ttgcccacc  gcatctcac  1080
gctagaatt  tctcctagt  ctggaacct  ccagattcc  gagaggctg  ctactcctg  1140
cttcctatc  ctgaataga  tagagggtt  tggaaagga  ccaaaaaat  ctgctaaga  1200
gcaattcac  cagatttcc  ttttttttt  ttaagagct  gccagagtc  tatgattta  1260
ccccataca  gccaggccg  ccagcctcg  ggcggggtg  tgcaacaac  gccagaacg  1320
cggctcagc  gggcggcca  cacgtgact  gagtactta  agggctggc  cgggcagct  1380
ctcgctcac  gtcgccagt  gcctccaga  tttccgcct  caaccagcg  gtggagcct  1440
ccggagcag  gccatctcg  gcggagccc  gagcctgaa  cgagcggag  cagcctgaa  1500
tagcccagt  ccgcgatgg  gcgcccaca  ctcgacagg  aagcgacta  ttggggacg  1560
gaactgtga  gtcccgcgt  ccttgtcca  cctagaaat  caggctgcg  gaccaagga  1620
cgagttgcc  cccagtcta  ctgtagcca  gggcagctg  agggagaaa  tgtgattca  1680
ccctctgac  cgctggagg  gaccggatg  gtgtgtctt  tagtatcca  gtttgaggg  1740
tgaacagtg  tgagtcctg  atcctggac  caccgttct  gggggcggg  gttggggag  1800
ttggccctc  tggtggcgc  gagtggtca  atcaattcc  aacttcaga  gacttgtaa  1860
acgcaggga  gcagccgta  cagaactag  gggtgttga  gctgggtgt  ttttgtttg  1920
ggatggggg  gacaggaag  tttttgttt  cttggtgtt  tgttctgtt  tgctttggg  1980
tccctgtgt  gatcaagtt  gccttgaac  ccagttcgc  tccctttgc  tcctgagta  2040
tgagattga  ggtgccccg  caccacact  ggcttctat  cctcctcct  ctcctcctc  2100
tccttctcc  cttcctcct  ttcctcttc  tcttcttcc  ccttctcct  ttcctcctt  2160
tcctctttg  ttttttttg  gacggagcg  ctctttgta  ccctggatg  cttcactct  2220
tagatcagg  tggcctaga  ctcggagat  tgcctgcct  tgcctccct  gtgctgaga  2280
tacaggcct  caccactct  tccagctct  ttttctttt  ttcctttta  aaagccagt  2340
ttattttta  atttttatt  aaagcgtct  gagttacat  taatttatc  tgcatgtag  2400
gtggccaca  atatgacac  ctaaatatg  ggaggtcag  gttcgactt  aagaaagtc  2460
cttctcagt  taccatgtg  cttccaaga  agattggct  atcaggtgg  aagtgcgtt  2520
cctggctga  cttacactg  ctagtcctc  cctccaact  ttagcagta  ggattgaac  2580
taggacttc  aacattcta  gcaagcgct  tacccataa  gtacagtat  agcaccttt  2640
ttatttaaa  acagtgcct  actaagttg  ccaggctgg  ctggaactc  tgaatcttc  2700
gctgcagaa  ctctctaaa  aaagctggg  tacatagac  atttaatgc  gaaactttg  2760
gtatagtgt  tagttggtt  tggatgggt  ttttgtttg  tttttgttt  gttttgctg  2820
gactcttcc  acatagccc  gtgctgaaa  tcattcact  tatagatag  cccaggttg  2880
ctttaaact  agagatctg  ctacctcca  ctcctgcat  ctggaatta  aggtgtgca  2940
catcacgtc  tgctgcttg  aaaatctgt  actgaaatt  tttaagaaa  atcttcagg  3000
tggatctaa  agctcacca  agtatctac  cttagccgg  ctgtggtgg  ccatgtctt  3060
aatcccagc  ctcaggagg  agagggaag  acatctcta  agttctggg  cagcctgct  3120
tacagagtg  gatccagga  agccagggc  acacagaga  acgctgtct  ggaaagaga  3180
aatctgccc  tgagtatgg  ccttggact  gcgtggctc  tccctgagg  caggacata  3240
cttgcctcc  cttcactgg  aataactgg  gtaggaatc  tccctgggg  tttggggac  3300
acgtcacat  gtgtttaat  actgacatc  gtttgcatg  ttaagatca  ggcttggcc  3360
acattggag  ctggagcta  tctgcaggt  taatcattc  taggcatcc  cggctgact  3420
tcctctctt  ctccacagc  tgtcccagg  tttgtccga  gccttgaag  aggccacca  3480
ggaggtgca  atccgtgca  agaattctg  gttcatgag  aactttcag  agggtcagg  3540
gtccaggga  ggctttaag  tacgtgacg  gtaggttga  cagaccact  gggtatagc  3600
ggtataccc  gggcttaag  caatagttt  atggggagg  tggtgccag  agtgatgag  3660
gcctgtcca  ggacgccat  ttggtaatg  tgaccctgt  gctcagaga  gaaagggtc  3720
gctggtgga  gagctggtg  agtggggtg  ttaagtgaa  acgtattct  tgttggtca  3780
tttatgttc  tgaggagtg  ctaaggaga  ggaacagag  ggttaaaga  gccatcctg  3840
cagctttca  tggaaaaga  caaaaccaa  gatggccaa  tttcagagc  tgcgctctt  3900
acctggtta  cgcagggcc  catacatgc  ggctaggtt  tctaccact  acccacaat  3960
caagctctt  ggttactag  tcgggtctc  ctacacagt  caggaactc  caatactcc  4020
gcgtcagcc  cccgggtat  tggaccatg  gagacccaa  tctcctgac  caatttcaa  4080
ttgcctctg  aggaaagga  aagtttgcc  tagccctgc  gtgtcctgt  cccacagtg  4140
gattggcta  ctcatttaa  ctcccaagc  ctcttgcct  aggaatggg  ttttgacag  4200
tgggctgaa  tgcacagta  acacaatag  ccctgtttc  tgccagctg  ggaactgat  4260
tctgcagca  acatcagac  cagggaaga  agcactgac  gggtgggga  tggagggtg  4320
tggagacag  agaccgtcc  tccagaagg  ttcttctag  gacaagttg  ttctgtttt  4380
ttcagctgg  gatggcctc  ttgtaccat  tctatacgg  cctggaaga  gagatagag  4440
gaaacaagc  gaacccagt  tatgccccg  tctacttcc  tgaggagct  caccgaagg  4500
ctgccctag  gcaggacat  gccttctgg  atgggcccc  ctggcagga  gccatccct  4560
acacaccag  cacacagca  tacgtaaag  gtctccacg  ggtgggagg  actcatcct  4620
agctgctgg  ggcccacgc  tatacccgc  acctgggtg  cctctcagg  ggtcaggtc  4680
tgaagaaga  tgcgcagaa  gccatggcc  tgccaagct  tggggaagg  ctggctttt  4740
tcaccttcc  gagcatcga  aaccccacc  agttcaaac  gctctatcg  gctcgcatg  4800
acactctgg  gatgacccc  gaggtcaag  acagggtga  agaagaggc  aagaccgcc  4860
tcctgctca  cattgaggt  agccccact  ttccttcaa  ccccattca  tccagttat  4920
ggaggaagg  tccccagag  cccagttag  acaaggact  ggggccagc  agggtcctg  4980
tttgctgct  aactagctg  gtgattgtg  gcaaatctc  tcatcctca  gttctaaat  5040
tccaaaata  ggataataa  agcatccat  ttcaaggcg  gaggggcaa  caagttgtg  5100
ttcagtccc  gtgggagga  tgatacagg  gaagttccc  gatgtcatt  ctctcttgt  5160
tggtgggct  tgatcctct  acaatggtg  agctggacc  ggggtgcct  agtactggt  5220
catggccag  ccagcacag  ccaggcttc  gatgctgac  tgtcccagg  ggcatttgc  5280
tccttttct  tgatttgca  tgatgtgtt  cccacgggt  tatctgttt  gtgtcagat  5340
cgttggggg  ggagctaca  acagctggg  gctgccaca  gggaaccgg  aattgaacc  5400
gcatcctct  gagagcaac  aacgctctt  atctttgaa  tatctttag  tcggtgttt  5460
gagcaaggc  ccgaaaggc  gagctgggg  agtagactg  cctatttat  ctatgggtg  5520
tatggtggt  agggttcca  tttgggacc  cctgtctct  cccactttc  gcctgagag  5580
ctttaaaag  tccaccagg  aagcacctg  tagagaagt  accttcaga  gtcctaaat  5640
catctaggc  cgttcacct  aggccttcc  aggacatga  ataaagaat  agtttagaa  5700
tggggaagt  atggcccat  cctttaatc  cagcactca  aaggcagag  caggaggat  5760
tctgtgagt  ccaggtcag  ttggtctac  cagctagtt  taggacagc  gaggctaca  5820
aaagaaacc  tgtcttgaa  aacaaaaca  aacaccaac  agaaaagag  attagacac  5880
ggcccagct  agaactggg  ctccatcct  acccctagt  gatctcaag  aagccctgc  5940
ccaggagct  tggttccct  acctgcaaa  gcagcgacc  tactccatt  cacgacaca  6000
cgcctagca  ggaggagct  aagtacagt  atgaagaga  cacgggatg  aggctgcac  6060
gctcccaca  attcgtgtg  tatttccga  gaggcaaac  ggttctcct  atagggata  6120
agaaaagct  ctgaagtct  tattcaggg  agccgttac  ggtggggtc  aagcgaggg  6180
acagacagt  tcggggacg  acaggcagg  agccaacta  acctgtcac  tctcatgag  6240
taagtgaaa  acgcggtat  cgatagttt  ctcaagtcg  gtcatttgt  caatatttc  6300
caacaggct  caagctgtg  cttcccctg  gtcccccca  attgtgagt  tcactaaca  6360
gcagtgtgt  ttgtcttgt  ttcagctgt  tgaggagct  caggcactg  tgacagagg  6420
acacaaaga  cagagtccc  cacagacag  gtttcttcg  cagaggcct  ctagcctgg  6480
tcaaggtaa  gatggcctc  tggcttctg  tctccttag  ccagctgga  tttctttac  6540
cttctccat  ctgaacgtt  taaattaga  atagggtgc  gacaaaaga  cccagggta  6600
gtctgtagt  tgactgtgg  taagctatc  gacttttct  ccttagttt  tccacatta  6660
aaaatcagg  ggttggggg  tgtgtagct  gttggctga  gggcatata  agccctcag  6720
agtcactgg  acagagatc  tctcattta  atcccgcct  ccacttctt  tcccccaag  6780
cagagccat  ctgcatgac  caggctggt  tcaaaccct  ggagtcaaa  aatcctcct  6840
cttcaatct  tcataaaaa  ctagggtgt  tttaccttt  gaggcccac  caaggctcc  6900
atgcaggcc  catatgagg  aaggatttg  gaagctatt  ctagcgctg  ccctccagg  6960
gacacgacg  agttcatgt  attactgga  tgtcagccc  tttcctgtg  cttgataca  7020
tacccttgg  gcaggagta  gggttctta  aaagaccaa  gtggcagaa  atgtgcctt  7080
cctgagcct  tcacccctg  gacagtatg  cccagggag  gggtgactg  aactgagca  7140
ggcaggtta  gtgaagctt  attgcttga  tgggcccac  ttttgccca  ggctctccc  7200
agggaggca  gacccgcca  cttgtcatt  gtggtactg  ttctggtgg  ctgaaatat  7260
gtcagtgct  atagaatta  ttacctgtt  gggtctgga  tctttgacc  gctgcggcc  7320
ggcggagca  aggaggaac  gcgtggggg  gttggtgag  tcctatctt  gaaggtgtt  7380
aagcagtgg  tagtggttc  agctgtagc  gaatcctgg  cttggactg  aactgtagc  7440
gacacggca  cgagtgtcc  ctgctctgt  cagtgtcat  caccccagg  tgtgtgttt  7500
accttgtct  tgtttctcc  acagatact  cctctgcag  gacgccccg  ggaaaatcc  7560
agatcagca  tagttcatc  cagacaccg  tcctgcgat  ggtcctcac  ctcagtttc  7620
tgttggcga  cgtggcagt  ggaatttat  ccatgtaaa  gcagtgttg  cccccagag  7680
ctgtgaact  tgtctcatg  agccttctc  ctgcagggg  gaatcttgc  tggctctct  7740
ttcttgggc  tctaagaaa  cttttgggg  tcctcgccc  cttcctgtg  cttcctttg  7800
ctctctgga  tggaaggag  tgcctggca  atttccctc  ccaaaagca  agccagggg  7860
ctgaacttg  aaaccagca  ccccaaatc  tgcaacaga  ccccagaac  gtggtcggt  7920
gaggcggct  ttctgagcc  agtgccctt  gtagtcggc  tccatgttg  ctgaccatg  7980
ctgctttcc  ccagcgtca  ggccacttt  atatcagtg  gcagagatt  tctgtcttg  8040
gtttctgtc  tgtttttgt  atttcccca  ttctaccag  gtaatggta  tttttgttg  8100
atcgattgt  tttttattc  aaccaagta  ggctgtctt  tgaggggtg  gtggtattt  8160
ataattgta  ccttggtct  taacttctg  gtgaaataa  aaatggcat  atctaataa  8220
caccggaag  tcgttcatg  ctctgccgt  cacgaacag  gccctgctc  tcctgtctc  8280
tcagtgtct  gcaggagga  ggcaggtgg  ggtggcatc  gtagctttg  cggtccact  8340
tgtctgaga  ttggaagtg  gcttcaagc  tttgggc  8377



<210> 2404
<211> 289
<212> PRT
<213> Rattus norvegicus
<308> AAA41346
<400> 2404

Met Glu Arg Pro Gln Leu Asp Ser Met Ser Gln Asp Leu Ser Glu Ala 
  1               5                  10                  15
Leu Lys Glu Ala Thr Lys Glu Val His Ile Arg Ala Glu Asn Ser Glu 
             20                  25                  30
Phe Met Arg Asn Phe Gln Lys Gly Gln Val Ser Arg Glu Gly Phe Lys 
         35                  40                  45
Leu Val Met Ala Ser Leu Tyr His Ile Tyr Thr Ala Leu Glu Glu Glu 
     50                  55                  60
Ile Glu Arg Asn Lys Gln Asn Pro Val Tyr Ala Pro Leu Tyr Phe Pro 
 65                  70                  75                  80
Glu Glu Leu His Arg Arg Ala Ala Leu Glu Gln Asp Met Ala Phe Trp 
                 85                  90                  95
Tyr Gly Pro His Trp Gln Glu Ala Ile Pro Tyr Thr Pro Ala Thr Gln 
             100                105                110
His Tyr Val Lys Arg Leu His Glu Val Gly Gly Thr His Pro Glu Leu 
         115                120                125
Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
     130                135                140
Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Met Ala Leu Pro Ser Ser 
 145                150                155                160
Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Ser Ile Asp Asn Pro Thr 
                 165                170                175
Lys Phe Lys Gln Leu Tyr Arg Ala Arg Met Asn Thr Leu Glu Met Thr 
             180                185                190
Pro Glu Val Lys His Arg Val Thr Glu Glu Ala Lys Thr Ala Phe Leu 
         195                200                205
Leu Asn Ile Glu Leu Phe Glu Glu Leu Gln Ala Leu Leu Thr Glu Glu 
     210                215                220
His Lys Asp Gln Ser Pro Ser Gln Thr Glu Phe Leu Arg Gln Arg Pro 
 225                230                235                240
Ala Ser Leu Val Gln Asp Thr Thr Ser Ala Glu Thr Pro Arg Gly Lys 
                 245                250                255
Ser Gln Ile Ser Thr Ser Ser Ser Gln Thr Pro Leu Leu Arg Trp Val 
             260                265                270
Leu Thr Leu Ser Phe Leu Leu Ala Thr Val Ala Val Gly Ile Tyr Ala 
         275                280                285
Met 
     290



<210> 2405
<211> 1550
<212> DNA
<213> Homo sapiens
<308> NM_002133
<400> 2405

tcaacgcct  cctcccctc  agcgtcctc  gcgcagccg  cgcccgcgg  gccagcacg  60
acgagccca  caccggccg  atggagcgt  cgcaacccg  cagcatgcc  caggatttg  120
cagaggccc  gaaggaggc  accaaggag  tgcacaccc  ggcagagaa  gctgagttc  180
tgaggaact  tcagaaggg  caggtgacc  gagacggct  caagctggt  atggcctcc  240
tgtaccaca  ctatgtggc  ctggaggag  agattgagc  caacaagga  agcccagtc  300
tcgcccctg  ctacttccc  gaagagctg  accgcaagg  tgccctgga  caggacctg  360
ccttctggt  cgggccccg  tggcaggag  tcatcccct  cacaccagc  atgcagcgc  420
atgtgaagc  gctccacga  gtggggcgc  cagagcccg  gctgctggt  gcccacgcc  480
acacccgct  cctgggtga  ctgtctggg  gccaggtgc  caaaaagat  gcccagaaa  540
ccctggacc  gcccagctc  ggcgagggc  tggccttct  caccttccc  aacattgcc  600
gtgccacca  gttcaagca  ctctaccgc  cccgcatga  ctccctgga  atgactccc  660
cagtcaggc  gagggtgat  gaagaggcc  agactgcgt  cctgctcaa  atccagctc  720
ttgaggagt  gcaggagct  ctgacccat  acaccaagg  ccagagccc  tcacgggca  780
cagggcttc  ccagcgggc  agcaacaaa  tgcaagatt  tgcccccgt  gagactccc  840
gagggaagc  cccactcaa  acccgctcc  aggctccgc  tctccgatg  gtccttaca  900
tcagctttc  ggtggcgac  gttgctgta  ggctttatg  catgtgaat  caggcatgc  960
ggctcccag  gccatgaac  ttgtccggt  gaaggcctt  tttctagag  gggaattct  1020
ttggctggc  tccttaccg  gggcactga  ggctttcag  gcctccagc  ctctcactg  1080
gtccctctc  ctggaaagg  ggaaggagc  tatggcatc  tccccaacg  aaagcacat  1140
caggcaatg  cctaaactt  agagggggc  aaggggtca  ccctgccct  cagcatcct  1200
agttcctgc  gcagagcct  gaagacacc  taatgtggc  gctgtctca  acctccaaa  1260
gccctgagt  tcaagtatc  ttgttgaca  ggccatgac  actttcccc  tgggccatg  1320
caattttta  acaaacctg  aaagatgtt  tgtcttgtg  ttttgtctt  tttttgttg  1380
agccactct  ttcctggct  agcctcaaa  gcagtattt  tgttgtgtt  tgttgtttt  1440
atagcaggg  tggggtggt  tttgagcca  gcgtgggtg  ggagggagg  gtttaacgg  1500
actgtggcc  tggtctaac  tttgtgtga  ataataaac  acattgtctg  1550



<210> 2406
<211> 288
<212> PRT
<213> Homo sapiens
<308> P09601
<400> 2406

Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
  1               5                  10                  15
Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
             20                  25                  30
Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
         35                  40                  45
Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
     50                  55                  60
Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
 65                  70                  75                  80
Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                 85                  90                  95
Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
             100                105                110
Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
         115                120                125
Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
     130                135                140
Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
 145                150                155                160
Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                 165                170                175
Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
             180                185                190
Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
         195                200                205
Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
     210                215                220
Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
 225                230                235                240
Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                 245                250                255
Pro Pro Leu Asn Thr Arg Ser Gln Ala Pro Leu Leu Arg Trp Val Leu 
             260                265                270
Thr Leu Ser Phe Leu Val Ala Thr Val Ala Val Gly Leu Tyr Ala Met 
         275                280                285



<210> 2407
<211> 1580
<212> DNA
<213> Rattus norvegicus
<308> J02749
<400> 2407

ctaatcggt  ggacgcacc  ccgcgatgc  tcggctgca  gtagtgctg  gccacctgg  60
cggccggtc  gagtcgagc  ccgcgctgc  agccgcgcc  tgctctgcg  gcttcccgc  120
ggcctcggc  tccgacgtg  tggtggtgc  cggacagcg  acccccatc  gccgcgccg  180
ccgcggcgg  ttcaaggac  ccacccccg  cgagcttct  tcggccgtg  tgaccgcgg  240
tctccagga  gtgaagcca  agcctgagt  tctgggaga  atctccgtg  gcaatgtgc  300
tcagcccgg  gccggagcc  caatggcac  catcgccca  ttcctgagt  gcatcccag  360
gaccgtgcc  ctgtcagca  tcaacagac  gtgttcatc  ggactgcag  cagtggcca  420
cattgctgg  ggcatcaga  atgggtctt  cgacattgg  atggcctgt  gggtggagt  480
catgaccct  tctgagaga  gcaaccctg  gaatatttc  tcccgtctt  tggagaacg  540
gaaggccag  gactgcctg  ttcctatgg  gataacctc  gagaatgtg  ctgagcggt  600
tggcatctc  cggcagaag  aggatgcct  cgcgctggc  tctcagcag  aggcagcaa  660
cgcccagag  aaaggctgc  tccgtgctg  gatcgtgcc  gtgacaacc  ctgtcctcg  720
tgacaaggg  gacaggaaa  ccatcaccg  gtctcagga  gagggtgtc  gccccagca  780
caccatgga  ggcctggcc  agctgaagc  tgccttcaa  gatggaggc  ctaccacgg  840
tggaaactc  agtcaggtg  gtgatggag  agccgccgt  ctgctggcc  ggaggtcca  900
ggctgaaga  ctgggcctc  ccatccttg  cgtcctgag  tcctatgca  tggtcgggg  960
ccctcctga  atcatgggc  tcggacctg  ctatgccat  cctgcggcc  tgcagaaag  1020
agggctgac  gtgaatgac  tagacatct  tgagatcaa  gaggccttt  caagtcagg  1080
cctctactg  gtggagaag  tgggaattc  tgcagaaaa  gtgaacccc  tggggggtg  1140
aatagccct  ggccacccc  tgggctgca  cggagcaag  caggtggtc  cgctgctca  1200
tgagctgaa  cgccgaggc  gacgggctt  tggcgtggt  tccatgtgc  tcgggactg  1260
gatgggagc  gctgctgtc  ttgaatacc  tgggaactg  ggccctgac  gcaggcact  1320
cccagagag  cctatagta  tgtctggag  gggatggta  agaagccat  ttcgtggga  1380
actcagcag  ggagggatt  gtcacagca  tttaattta  aaaatgtaa  cgcaatacg  1440
gcacaaggg  atccaatcc  ctcctctca  ttgaaccaa  gacagcgca  gtcacacgt  1500
accacagga  aacatgttt  tgagggaca  tggcctcat  aatagtggg  atgaggggc  1560
tagtaaatg  atgttatctc  1580



<210> 2408
<211> 434
<212> PRT
<213> Rattus norvegicus
<308> P21775
<400> 2408

Met Ser Glu Ser Val Gly Arg Thr Ser Ala Met His Arg Leu Gln Val 
  1               5                  10                  15
Val Leu Gly His Leu Ala Gly Arg Pro Glu Ser Ser Ser Ala Leu Gln 
             20                  25                  30
Ala Ala Pro Cys Ser Ala Thr Phe Pro Gln Ala Ser Ala Ser Asp Val 
         35                  40                  45
Val Val Val His Gly Arg Arg Thr Pro Ile Gly Arg Ala Gly Arg Gly 
     50                  55                  60
Gly Phe Lys Asp Thr Thr Pro Asp Glu Leu Leu Ser Ala Val Leu Thr 
 65                  70                  75                  80
Ala Val Leu Gln Asp Val Lys Leu Lys Pro Glu Cys Leu Gly Asp Ile 
                 85                  90                  95
Ser Val Gly Asn Val Leu Glu Pro Gly Ala Gly Ala Val Met Ala Arg 
             100                105                110
Ile Ala Gln Phe Leu Ser Gly Ile Pro Glu Thr Val Pro Leu Ser Ala 
         115                120                125
Val Asn Arg Gln Cys Ser Ser Gly Leu Gln Ala Val Ala Asn Ile Ala 
     130                135                140
Gly Gly Ile Arg Asn Gly Ser Tyr Asp Ile Gly Met Ala Cys Gly Val 
 145                150                155                160
Glu Ser Met Ser Leu Ser Asn Arg Gly Asn Pro Gly Asn Ile Ser Ser 
                 165                170                175
Arg Leu Leu Glu Ser Asp Lys Ala Arg Asp Cys Leu Ile Pro Met Gly 
             180                185                190
Ile Thr Ser Glu Asn Val Ala Glu Arg Phe Gly Ile Ser Arg Gln Lys 
         195                200                205
Gln Asp Ala Phe Ala Leu Ala Ser Gln Gln Lys Ala Ala Ser Ala Gln 
     210                215                220
Ser Lys Gly Cys Phe Arg Ala Glu Ile Val Pro Val Thr Thr Thr Val 
 225                230                235                240
Leu Asp Asp Lys Gly Asp Arg Lys Thr Ile Thr Val Ser Gln Asp Glu 
                 245                250                255
Gly Val Arg Pro Ser Thr Thr Met Glu Gly Leu Ala Lys Leu Lys Pro 
             260                265                270
Ala Phe Lys Asp Gly Gly Ser Thr Thr Ala Gly Asn Ser Ser Gln Val 
         275                280                285
Ser Asp Gly Ala Ala Ala Val Leu Leu Ala Arg Arg Ser Lys Ala Glu 
     290                295                300
Glu Leu Gly Leu Pro Ile Leu Gly Val Leu Arg Ser Tyr Ala Val Val 
 305                310                315                320
Gly Val Pro Pro Asp Ile Met Gly Ile Gly Pro Ala Tyr Ala Ile Pro 
                 325                330                335
Ala Ala Leu Gln Lys Ala Gly Leu Thr Val Asn Asp Ile Asp Ile Phe 
             340                345                350
Glu Ile Asn Glu Ala Phe Ala Ser Gln Ala Leu Tyr Cys Val Glu Lys 
         355                360                365
Leu Gly Ile Pro Ala Glu Lys Val Asn Pro Leu Gly Gly Ala Ile Ala 
     370                375                380
Leu Gly His Pro Leu Gly Cys Thr Gly Ala Arg Gln Val Val Thr Leu 
 385                390                395                400
Leu Asn Glu Leu Lys Arg Arg Gly Arg Arg Ala Tyr Gly Val Val Ser 
                 405                410                415
Met Cys Ile Gly Thr Gly Met Gly Ala Ala Ala Val Phe Glu Tyr Pro 
             420                425                430
Gly Asn 
         435



<210> 2409
<211> 1391
<212> DNA
<213> Homo sapiens
<308> X12966
<400> 2409

tgcgcaatg  agaggctgc  ggtagtgct  ggccacctg  ggggtccgg  cgattccgg  60
tggatgccg  aggccgcgc  ttgcctgag  ggtgccccg  aggcctcgg  cgcggacgt  120
gtggtggtg  acgggcggc  cacggccat  tgccgggcg  gccgcggcg  cttcaagga  180
accaccccc  acgagcttc  ctcggcagt  atgaccgcg  ttctcaagg  cgtgaatct  240
aggccggaa  agctggggg  catctgtgt  ggaaatgtg  tgcagcctg  ggccggggc  300
atcatggcc  gaatcgccc  gtttctgag  gacatcccg  agactgtgc  tttgtccac  360
gtcaataga  agtgctcgt  ggggctaca  gcagtggcc  gcatagcag  tggcatcag  420
aatgggtct  atgacattg  catggcctg  ggggtggag  ccatgtccc  ggctgacag  480
gggaaccct  gaaatatta  ttcgcgctt  atggagaag  agaaggcca  agattgcct  540
attcctatg  ggataacct  tgagaatgt  gctgagcgg  ttggcattt  acgggagaa  600
caggatacc  ttgccctgg  ttcccagca  aaggcagca  gagcccaga  caagggctg  660
ttccaagct  agattgtgc  tgtgaccac  acggtccat  atgacaagg  caccaagag  720
agcatcact  tgacccagg  tgagggtat  cgccccagc  ccaccatgg  gggcctggc  780
aaactgaag  ctgccttca  gaaagatgg  tctaccaca  ctggaaact  tagccaggt  840
agtgatggg  cagctgcca  cctgctggc  cggaggtcc  aggcagaag  gttgggcct  900
cccatcctt  gggtcctga  gtcttatgc  gtggttggg  tcccacctg  catcatggg  960
attggacct  cctatgcca  cccagtagc  ttgcaaaaa  cagggctga  agtgagtga  1020
gtggacatc  tcgagatca  tgaggcctt  gcaagccag  ctgcctact  tgtggagaa  1080
ctacgactc  cccctgaga  ggtgaaccc  ctggggggt  cagtggcct  agggcaccc  1140
ctgggctgc  ctggggcac  acaggtcat  acgctgctc  atgagctga  gcgccgtgg  1200
aagagggca  acggagtgg  gtccatgtg  atcgggact  gaatgggag  cgctgccgt  1260
tttgaatac  ctgggaact  agtgaggtc  caggctgga  gcgctacgc  gacagtcct  1320
ctgctctag  agcaaggca  taacaccac  aaagcaaaa  cacatggga  aactcagca  1380
tggtggtgg  g  1391



<210> 2410
<211> 424
<212> PRT
<213> Homo sapiens
<308> P09110
<400> 2410

Met Gln Arg Leu Gln Val Val Leu Gly His Leu Arg Gly Pro Ala Asp 
  1               5                  10                  15
Ser Gly Trp Met Pro Gln Ala Ala Pro Cys Leu Ser Gly Ala Pro Gln 
             20                  25                  30
Ala Ser Ala Ala Asp Val Val Val Val His Gly Arg Arg Thr Ala Ile 
         35                  40                  45
Cys Arg Ala Gly Arg Gly Gly Phe Lys Asp Thr Thr Pro Asp Glu Leu 
     50                  55                  60
Leu Ser Ala Val Met Thr Ala Val Leu Lys Asp Val Asn Leu Arg Pro 
 65                  70                  75                  80
Glu Gln Leu Gly Asp Ile Cys Val Gly Asn Val Leu Gln Pro Gly Ala 
                 85                  90                  95
Gly Ala Ile Met Ala Arg Ile Ala Gln Phe Leu Ser Asp Ile Pro Glu 
             100                105                110
Thr Val Pro Leu Ser Thr Val Asn Arg Gln Cys Ser Ser Gly Leu Gln 
         115                120                125
Ala Val Ala Ser Ile Ala Gly Gly Ile Arg Asn Gly Ser Tyr Asp Ile 
     130                135                140
Gly Met Ala Cys Gly Val Glu Ser Met Ser Leu Ala Asp Arg Gly Asn 
 145                150                155                160
Pro Gly Asn Ile Thr Ser Arg Leu Met Glu Lys Glu Lys Ala Arg Asp 
                 165                170                175
Cys Leu Ile Pro Met Gly Ile Thr Ser Glu Asn Val Ala Glu Arg Phe 
             180                185                190
Gly Ile Ser Arg Glu Lys Gln Asp Thr Phe Ala Leu Ala Ser Gln Gln 
         195                200                205
Lys Ala Ala Arg Ala Gln Ser Lys Gly Cys Phe Gln Ala Glu Ile Val 
     210                215                220
Pro Val Thr Thr Thr Val His Asp Asp Lys Gly Thr Lys Arg Ser Ile 
 225                230                235                240
Thr Val Thr Gln Asp Glu Gly Ile Arg Pro Ser Thr Thr Met Glu Gly 
                 245                250                255
Leu Ala Lys Leu Lys Pro Ala Phe Lys Lys Asp Gly Ser Thr Thr Ala 
             260                265                270
Gly Asn Ser Ser Gln Val Ser Asp Gly Ala Ala Ala Ile Leu Leu Ala 
         275                280                285
Arg Arg Ser Lys Ala Glu Glu Leu Gly Leu Pro Ile Leu Gly Val Leu 
     290                295                300
Arg Ser Tyr Ala Val Val Gly Val Pro Pro Asp Ile Met Gly Ile Gly 
 305                310                315                320
Pro Ala Tyr Ala Ile Pro Val Ala Leu Gln Lys Ala Gly Leu Thr Val 
                 325                330                335
Ser Asp Val Asp Ile Phe Glu Ile Asn Glu Ala Phe Ala Ser Gln Ala 
             340                345                350
Ala Tyr Cys Val Glu Lys Leu Arg Leu Pro Pro Glu Lys Val Asn Pro 
         355                360                365
Leu Gly Gly Ala Val Ala Leu Gly His Pro Leu Gly Cys Thr Gly Ala 
     370                375                380
Arg Gln Val Ile Thr Leu Leu Asn Glu Leu Lys Arg Arg Gly Lys Arg 
 385                390                395                400
Ala Tyr Gly Val Val Ser Met Cys Ile Gly Thr Gly Met Gly Ala Ala 
                 405                410                415
Ala Val Phe Glu Tyr Pro Gly Asn 
             420



<210> 2411
<211> 1580
<212> DNA
<213> Rattus norvegicus
<308> J02749
<400> 2411

ctaatcggt  ggacgcacc  ccgcgatgc  tcggctgca  gtagtgctg  gccacctgg  60
cggccggtc  gagtcgagc  ccgcgctgc  agccgcgcc  tgctctgcg  gcttcccgc  120
ggcctcggc  tccgacgtg  tggtggtgc  cggacagcg  acccccatc  gccgcgccg  180
ccgcggcgg  ttcaaggac  ccacccccg  cgagcttct  tcggccgtg  tgaccgcgg  240
tctccagga  gtgaagcca  agcctgagt  tctgggaga  atctccgtg  gcaatgtgc  300
tcagcccgg  gccggagcc  caatggcac  catcgccca  ttcctgagt  gcatcccag  360
gaccgtgcc  ctgtcagca  tcaacagac  gtgttcatc  ggactgcag  cagtggcca  420
cattgctgg  ggcatcaga  atgggtctt  cgacattgg  atggcctgt  gggtggagt  480
catgaccct  tctgagaga  gcaaccctg  gaatatttc  tcccgtctt  tggagaacg  540
gaaggccag  gactgcctg  ttcctatgg  gataacctc  gagaatgtg  ctgagcggt  600
tggcatctc  cggcagaag  aggatgcct  cgcgctggc  tctcagcag  aggcagcaa  660
cgcccagag  aaaggctgc  tccgtgctg  gatcgtgcc  gtgacaacc  ctgtcctcg  720
tgacaaggg  gacaggaaa  ccatcaccg  gtctcagga  gagggtgtc  gccccagca  780
caccatgga  ggcctggcc  agctgaagc  tgccttcaa  gatggaggc  ctaccacgg  840
tggaaactc  agtcaggtg  gtgatggag  agccgccgt  ctgctggcc  ggaggtcca  900
ggctgaaga  ctgggcctc  ccatccttg  cgtcctgag  tcctatgca  tggtcgggg  960
ccctcctga  atcatgggc  tcggacctg  ctatgccat  cctgcggcc  tgcagaaag  1020
agggctgac  gtgaatgac  tagacatct  tgagatcaa  gaggccttt  caagtcagg  1080
cctctactg  gtggagaag  tgggaattc  tgcagaaaa  gtgaacccc  tggggggtg  1140
aatagccct  ggccacccc  tgggctgca  cggagcaag  caggtggtc  cgctgctca  1200
tgagctgaa  cgccgaggc  gacgggctt  tggcgtggt  tccatgtgc  tcgggactg  1260
gatgggagc  gctgctgtc  ttgaatacc  tgggaactg  ggccctgac  gcaggcact  1320
cccagagag  cctatagta  tgtctggag  gggatggta  agaagccat  ttcgtggga  1380
actcagcag  ggagggatt  gtcacagca  tttaattta  aaaatgtaa  cgcaatacg  1440
gcacaaggg  atccaatcc  ctcctctca  ttgaaccaa  gacagcgca  gtcacacgt  1500
accacagga  aacatgttt  tgagggaca  tggcctcat  aatagtggg  atgaggggc  1560
tagtaaatg  atgttatctc  1580



<210> 2412
<211> 434
<212> PRT
<213> Rattus norvegicus
<308> P21775
<400> 2412

Met Ser Glu Ser Val Gly Arg Thr Ser Ala Met His Arg Leu Gln Val 
  1               5                  10                  15
Val Leu Gly His Leu Ala Gly Arg Pro Glu Ser Ser Ser Ala Leu Gln 
             20                  25                  30
Ala Ala Pro Cys Ser Ala Thr Phe Pro Gln Ala Ser Ala Ser Asp Val 
         35                  40                  45
Val Val Val His Gly Arg Arg Thr Pro Ile Gly Arg Ala Gly Arg Gly 
     50                  55                  60
Gly Phe Lys Asp Thr Thr Pro Asp Glu Leu Leu Ser Ala Val Leu Thr 
 65                  70                  75                  80
Ala Val Leu Gln Asp Val Lys Leu Lys Pro Glu Cys Leu Gly Asp Ile 
                 85                  90                  95
Ser Val Gly Asn Val Leu Glu Pro Gly Ala Gly Ala Val Met Ala Arg 
             100                105                110
Ile Ala Gln Phe Leu Ser Gly Ile Pro Glu Thr Val Pro Leu Ser Ala 
         115                120                125
Val Asn Arg Gln Cys Ser Ser Gly Leu Gln Ala Val Ala Asn Ile Ala 
     130                135                140
Gly Gly Ile Arg Asn Gly Ser Tyr Asp Ile Gly Met Ala Cys Gly Val 
 145                150                155                160
Glu Ser Met Ser Leu Ser Asn Arg Gly Asn Pro Gly Asn Ile Ser Ser 
                 165                170                175
Arg Leu Leu Glu Ser Asp Lys Ala Arg Asp Cys Leu Ile Pro Met Gly 
             180                185                190
Ile Thr Ser Glu Asn Val Ala Glu Arg Phe Gly Ile Ser Arg Gln Lys 
         195                200                205
Gln Asp Ala Phe Ala Leu Ala Ser Gln Gln Lys Ala Ala Ser Ala Gln 
     210                215                220
Ser Lys Gly Cys Phe Arg Ala Glu Ile Val Pro Val Thr Thr Thr Val 
 225                230                235                240
Leu Asp Asp Lys Gly Asp Arg Lys Thr Ile Thr Val Ser Gln Asp Glu 
                 245                250                255
Gly Val Arg Pro Ser Thr Thr Met Glu Gly Leu Ala Lys Leu Lys Pro 
             260                265                270
Ala Phe Lys Asp Gly Gly Ser Thr Thr Ala Gly Asn Ser Ser Gln Val 
         275                280                285
Ser Asp Gly Ala Ala Ala Val Leu Leu Ala Arg Arg Ser Lys Ala Glu 
     290                295                300
Glu Leu Gly Leu Pro Ile Leu Gly Val Leu Arg Ser Tyr Ala Val Val 
 305                310                315                320
Gly Val Pro Pro Asp Ile Met Gly Ile Gly Pro Ala Tyr Ala Ile Pro 
                 325                330                335
Ala Ala Leu Gln Lys Ala Gly Leu Thr Val Asn Asp Ile Asp Ile Phe 
             340                345                350
Glu Ile Asn Glu Ala Phe Ala Ser Gln Ala Leu Tyr Cys Val Glu Lys 
         355                360                365
Leu Gly Ile Pro Ala Glu Lys Val Asn Pro Leu Gly Gly Ala Ile Ala 
     370                375                380
Leu Gly His Pro Leu Gly Cys Thr Gly Ala Arg Gln Val Val Thr Leu 
 385                390                395                400
Leu Asn Glu Leu Lys Arg Arg Gly Arg Arg Ala Tyr Gly Val Val Ser 
                 405                410                415
Met Cys Ile Gly Thr Gly Met Gly Ala Ala Ala Val Phe Glu Tyr Pro 
             420                425                430
Gly Asn 
         435



<210> 2413
<211> 1391
<212> DNA
<213> Homo sapiens
<308> X12966
<400> 2413

tgcgcaatg  agaggctgc  ggtagtgct  ggccacctg  ggggtccgg  cgattccgg  60
tggatgccg  aggccgcgc  ttgcctgag  ggtgccccg  aggcctcgg  cgcggacgt  120
gtggtggtg  acgggcggc  cacggccat  tgccgggcg  gccgcggcg  cttcaagga  180
accaccccc  acgagcttc  ctcggcagt  atgaccgcg  ttctcaagg  cgtgaatct  240
aggccggaa  agctggggg  catctgtgt  ggaaatgtg  tgcagcctg  ggccggggc  300
atcatggcc  gaatcgccc  gtttctgag  gacatcccg  agactgtgc  tttgtccac  360
gtcaataga  agtgctcgt  ggggctaca  gcagtggcc  gcatagcag  tggcatcag  420
aatgggtct  atgacattg  catggcctg  ggggtggag  ccatgtccc  ggctgacag  480
gggaaccct  gaaatatta  ttcgcgctt  atggagaag  agaaggcca  agattgcct  540
attcctatg  ggataacct  tgagaatgt  gctgagcgg  ttggcattt  acgggagaa  600
caggatacc  ttgccctgg  ttcccagca  aaggcagca  gagcccaga  caagggctg  660
ttccaagct  agattgtgc  tgtgaccac  acggtccat  atgacaagg  caccaagag  720
agcatcact  tgacccagg  tgagggtat  cgccccagc  ccaccatgg  gggcctggc  780
aaactgaag  ctgccttca  gaaagatgg  tctaccaca  ctggaaact  tagccaggt  840
agtgatggg  cagctgcca  cctgctggc  cggaggtcc  aggcagaag  gttgggcct  900
cccatcctt  gggtcctga  gtcttatgc  gtggttggg  tcccacctg  catcatggg  960
attggacct  cctatgcca  cccagtagc  ttgcaaaaa  cagggctga  agtgagtga  1020
gtggacatc  tcgagatca  tgaggcctt  gcaagccag  ctgcctact  tgtggagaa  1080
ctacgactc  cccctgaga  ggtgaaccc  ctggggggt  cagtggcct  agggcaccc  1140
ctgggctgc  ctggggcac  acaggtcat  acgctgctc  atgagctga  gcgccgtgg  1200
aagagggca  acggagtgg  gtccatgtg  atcgggact  gaatgggag  cgctgccgt  1260
tttgaatac  ctgggaact  agtgaggtc  caggctgga  gcgctacgc  gacagtcct  1320
ctgctctag  agcaaggca  taacaccac  aaagcaaaa  cacatggga  aactcagca  1380
tggtggtgg  g  1391



<210> 2414
<211> 424
<212> PRT
<213> Homo sapiens
<308> P09110
<400> 2414

Met Gln Arg Leu Gln Val Val Leu Gly His Leu Arg Gly Pro Ala Asp 
  1               5                  10                  15
Ser Gly Trp Met Pro Gln Ala Ala Pro Cys Leu Ser Gly Ala Pro Gln 
             20                  25                  30
Ala Ser Ala Ala Asp Val Val Val Val His Gly Arg Arg Thr Ala Ile 
         35                  40                  45
Cys Arg Ala Gly Arg Gly Gly Phe Lys Asp Thr Thr Pro Asp Glu Leu 
     50                  55                  60
Leu Ser Ala Val Met Thr Ala Val Leu Lys Asp Val Asn Leu Arg Pro 
 65                  70                  75                  80
Glu Gln Leu Gly Asp Ile Cys Val Gly Asn Val Leu Gln Pro Gly Ala 
                 85                  90                  95
Gly Ala Ile Met Ala Arg Ile Ala Gln Phe Leu Ser Asp Ile Pro Glu 
             100                105                110
Thr Val Pro Leu Ser Thr Val Asn Arg Gln Cys Ser Ser Gly Leu Gln 
         115                120                125
Ala Val Ala Ser Ile Ala Gly Gly Ile Arg Asn Gly Ser Tyr Asp Ile 
     130                135                140
Gly Met Ala Cys Gly Val Glu Ser Met Ser Leu Ala Asp Arg Gly Asn 
 145                150                155                160
Pro Gly Asn Ile Thr Ser Arg Leu Met Glu Lys Glu Lys Ala Arg Asp 
                 165                170                175
Cys Leu Ile Pro Met Gly Ile Thr Ser Glu Asn Val Ala Glu Arg Phe 
             180                185                190
Gly Ile Ser Arg Glu Lys Gln Asp Thr Phe Ala Leu Ala Ser Gln Gln 
         195                200                205
Lys Ala Ala Arg Ala Gln Ser Lys Gly Cys Phe Gln Ala Glu Ile Val 
     210                215                220
Pro Val Thr Thr Thr Val His Asp Asp Lys Gly Thr Lys Arg Ser Ile 
 225                230                235                240
Thr Val Thr Gln Asp Glu Gly Ile Arg Pro Ser Thr Thr Met Glu Gly 
                 245                250                255
Leu Ala Lys Leu Lys Pro Ala Phe Lys Lys Asp Gly Ser Thr Thr Ala 
             260                265                270
Gly Asn Ser Ser Gln Val Ser Asp Gly Ala Ala Ala Ile Leu Leu Ala 
         275                280                285
Arg Arg Ser Lys Ala Glu Glu Leu Gly Leu Pro Ile Leu Gly Val Leu 
     290                295                300
Arg Ser Tyr Ala Val Val Gly Val Pro Pro Asp Ile Met Gly Ile Gly 
 305                310                315                320
Pro Ala Tyr Ala Ile Pro Val Ala Leu Gln Lys Ala Gly Leu Thr Val 
                 325                330                335
Ser Asp Val Asp Ile Phe Glu Ile Asn Glu Ala Phe Ala Ser Gln Ala 
             340                345                350
Ala Tyr Cys Val Glu Lys Leu Arg Leu Pro Pro Glu Lys Val Asn Pro 
         355                360                365
Leu Gly Gly Ala Val Ala Leu Gly His Pro Leu Gly Cys Thr Gly Ala 
     370                375                380
Arg Gln Val Ile Thr Leu Leu Asn Glu Leu Lys Arg Arg Gly Lys Arg 
 385                390                395                400
Ala Tyr Gly Val Val Ser Met Cys Ile Gly Thr Gly Met Gly Ala Ala 
                 405                410                415
Ala Val Phe Glu Tyr Pro Gly Asn 
             420



<210> 2415
<211> 666
<212> DNA
<213> Rattus norvegicus
<308> J02773
<400> 2415

ctcacgacc  acatcgacc  cctttctca  tgcaccatg  cggacgcct  tgtcggtac  60
tggaagcta  tggacagca  gaattttga  gactacatg  agtcactcg  tgtgggctt  120
gccaccaga  aggtggcta  catgaccaa  ccgaccaca  tcattgaga  gaatgggga  180
accatcacc  taaagacac  cagtacctt  aagaacaca  agatcagct  tcagctggg  240
gtagagttt  acgaggtca  agcagatga  aggaaggtc  agtcggtcg  gacactgga  300
ggaggcaaa  tggtccatg  gcagaagtg  gacgggcag  agactacgc  tacacggga  360
ctaagtgat  ggaaactca  cctgactct  acccatggc  atgtggtga  cactcggac  420
tacgagaag  aggcgtgac  tggctgccc  gtcactgac  gctcctctg  caatggcta  480
ccctaactc  gcaccacgt  gcctcatgt  tctcccctc  gacgtttta  ataaatact  540
tttggttgg  cttttcctg  agatatggg  caccagcct  gacccaggt  ccattgtgt  600
tgtggttta  tttttaaat  tatccaaag  gtgctccaa  gtcaataaa  cagagccaa  660
gccacc  666



<210> 2416
<211> 132
<212> PRT
<213> Rattus norvegicus
<308> P07483
<400> 2416

Ala Asp Ala Phe Val Gly Thr Trp Lys Leu Val Asp Ser Lys Asn Phe 
  1               5                  10                  15
Asp Asp Tyr Met Lys Ser Leu Gly Val Gly Phe Ala Thr Arg Gln Val 
             20                  25                  30
Ala Ser Met Thr Lys Pro Thr Thr Ile Ile Glu Lys Asn Gly Asp Thr 
         35                  40                  45
Ile Thr Ile Lys Thr His Ser Thr Phe Lys Asn Thr Glu Ile Ser Phe 
     50                  55                  60
Gln Leu Gly Val Glu Phe Asp Glu Val Thr Ala Asp Asp Arg Lys Val 
 65                  70                  75                  80
Lys Ser Val Val Thr Leu Asp Gly Gly Lys Leu Val His Val Gln Lys 
                 85                  90                  95
Trp Asp Gly Gln Glu Thr Thr Leu Thr Arg Glu Leu Ser Asp Gly Lys 
             100                105                110
Leu Ile Leu Thr Leu Thr His Gly Asn Val Val Ser Thr Arg Thr Tyr 
         115                120                125
Glu Lys Glu Ala 
     130



<210> 2417
<211> 679
<212> DNA
<213> Homo sapiens
<308> NM_004102
<400> 2417

gaattcggc  cgaggtagc  tctctcagc  tagcccagc  tcactatgg  ggacgcttt  60
ctgggcacc  ggaagctag  ggacagcaa  aatttcgat  actacatga  gtcactcgg  120
gtgggtttt  ctaccaggc  ggtggccag  atgaccaag  ctaccacaa  catcgaaaa  180
aatggggac  ttctcaccc  aaaaacaca  agcaccttc  agaacacag  gatcagctt  240
aagttgggg  tggagttcg  tgagacaac  gcagatgac  ggaaggtca  gtccattgt  300
acactggat  gagggaaac  tgttcacct  cagaaatgg  acgggcaag  gaccacact  360
gtgcgggag  taattgatg  aaaactcat  ctgacactc  cccacggca  tgcagtttg  420
actcgcact  acgagaaag  ggcatgacc  gactgcact  ttgctgact  ctactctgc  480
aatcggcta  ccctcgact  gcaccacat  gcctcattt  ttcctctga  tttgtacaa  540
tccacgaat  cttctgggg  caggtgcca  tgaccggga  ccagttcca  ttcccatgg  600
gtatgtggt  ttttttttt  tttttttta  ctgcactca  agggtgctc  gaggtcaat  660
aagcagagc  aaggccacc  679



<210> 2418
<211> 132
<212> PRT
<213> Homo sapiens
<308> P05413
<400> 2418

Val Asp Ala Phe Leu Gly Thr Trp Lys Leu Val Asp Ser Lys Asn Phe 
  1               5                  10                  15
Asp Asp Tyr Met Lys Ser Leu Gly Val Gly Phe Ala Thr Arg Gln Val 
             20                  25                  30
Ala Ser Met Thr Lys Pro Thr Thr Ile Ile Glu Lys Asn Gly Asp Ile 
         35                  40                  45
Leu Thr Leu Lys Thr His Ser Thr Phe Lys Asn Thr Glu Ile Ser Phe 
     50                  55                  60
Lys Leu Gly Val Glu Phe Asp Glu Thr Thr Ala Asp Asp Arg Lys Val 
 65                  70                  75                  80
Lys Ser Ile Val Thr Leu Asp Gly Gly Lys Leu Val His Leu Gln Lys 
                 85                  90                  95
Trp Asp Gly Gln Glu Thr Thr Leu Val Arg Glu Leu Ile Asp Gly Lys 
             100                105                110
Leu Ile Leu Thr Leu Thr His Gly Thr Ala Val Cys Thr Arg Thr Tyr 
         115                120                125
Glu Lys Glu Ala 
     130



<210> 2419
<211> 1008
<212> DNA
<213> Rattus norvegicus
<308> J02776
<400> 2419

atgagcaaa  gcaaggcgc  gcaggagac  ctcaacggc  gcatcacgg  catgctcgt  60
gaactcgca  actttgaga  gaacgtgag  caggcgatc  acaagtaca  tgcatacag  120
aaagcagca  ctgtgatag  aaagtaccc  cacaaaatc  agagtggag  agaagctaa  180
aaattgcca  gagtaggaa  aaaaattgc  gaaaagatt  atgaatttt  agcaactgg  240
aaattgcgt  aactggaaa  gattcgtca  gatgataca  gttcatcca  caacttcct  300
actcgagtt  ctggcatcg  gccatctgc  gcaaggaag  ttgtagatg  aggaattaa  360
acattagaa  atctcagga  aaatgaaga  aaattgaac  accatcagc  aattgggct  420
aaatatttt  aggactttg  aaagagaat  cctcgtgag  agatgctgc  aatgcagga  480
attgttctt  atgaagtta  aaagctgga  cccgagtac  tcgctacag  ctgcggcag  540
ttccgaaga  gcgcagagt  cagtggaga  atggacgtt  tgctgaccc  cccaaactt  600
acgtcagaa  caagcaaac  gccaaagtt  ttacatcgt  ttgtggaac  gttacaaaa  660
gtccgtttc  ttacagata  tcgttcaaa  ggtgagaca  agttcatgg  tgtttgcca  720
cttcccagc  agaatgatg  aaacgaata  ccacacagg  gaatcgata  caggttgat  780
cccaaagat  agtactact  tggtgttct  tacttcact  gaagtgaca  ctttaataa  840
aatatgaga  cgcatgccc  ggaaaaggg  ttcacaatc  atgagtaca  catccgccc  900
ctgggggtc  ctggggttg  tggggagcc  cttccggtg  acagcgagc  ggacatttt  960
gattacatc  agtggcgct  ccgggagcc  aaggacagg  gtgaatga  1008



<210> 2420
<211> 334
<212> PRT
<213> Rattus norvegicus
<308> P06766
<400> 2420

Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr Asp 
  1               5                  10                  15
Met Leu Val Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala Ile 
             20                  25                  30
His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys Tyr 
         35                  40                  45
Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly Val 
     50                  55                  60
Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly Lys 
 65                  70                  75                  80
Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser Ile 
                 85                  90                  95
Asn Phe Leu Thr Arg Val Thr Gly Ile Gly Pro Ser Ala Ala Arg Lys 
             100                105                110
Leu Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn Glu 
         115                120                125
Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys Tyr Phe Glu Asp 
     130                135                140
Phe Glu Lys Arg Ile Pro Arg Glu Glu Met Leu Gln Met Gln Asp Ile 
 145                150                155                160
Val Leu Asn Glu Val Lys Lys Leu Asp Pro Glu Tyr Ile Ala Thr Val 
                 165                170                175
Cys Gly Ser Phe Arg Arg Gly Ala Glu Ser Ser Gly Asp Met Asp Val 
             180                185                190
Leu Leu Thr His Pro Asn Phe Thr Ser Glu Ser Ser Lys Gln Pro Lys 
         195                200                205
Leu Leu His Arg Val Val Glu Gln Leu Gln Lys Val Arg Phe Ile Thr 
     210                215                220
Asp Thr Leu Ser Lys Gly Glu Thr Lys Phe Met Gly Val Cys Gln Leu 
 225                230                235                240
Pro Ser Glu Asn Asp Glu Asn Glu Tyr Pro His Arg Arg Ile Asp Ile 
                 245                250                255
Arg Leu Ile Pro Lys Asp Gln Tyr Tyr Cys Gly Val Leu Tyr Phe Thr 
             260                265                270
Gly Ser Asp Ile Phe Asn Lys Asn Met Arg Ala His Ala Leu Glu Lys 
         275                280                285
Gly Phe Thr Ile Asn Glu Tyr Thr Ile Arg Pro Leu Gly Val Thr Gly 
     290                295                300
Val Ala Gly Glu Pro Leu Pro Val Asp Ser Glu Gln Asp Ile Phe Asp 
 305                310                315                320
Tyr Ile Gln Trp Arg Tyr Arg Glu Pro Lys Asp Arg Ser Glu 
                 325                330



<210> 2421
<211> 1259
<212> DNA
<213> Homo sapiens
<308> M13140
<400> 2421

ccggagctg  gttgctcct  ctcccgtct  caagtcctg  tacctcctt  aagctggga  60
agggctcta  tccctggtt  tgaacactc  ggggttctc  ggtgcaggc  gccatgagc  120
aacggaagg  gccgcagga  actctcaac  ggggaatca  cgacatgct  acagaactc  180
caaactttg  gaagaacgt  agccaagct  tccacaagt  caatgctta  agaaaagca  240
catctgtta  agcaaaata  ccacacaaa  taaagagtg  agctgaagc  aagaaattg  300
ctggagtag  aacaaaaat  gctgaaaag  ttgatgagt  tttagcaac  ggaaaatta  360
gtaaactgg  aaagattcg  caggatgat  cgagttcat  catcaattt  ctgactcga  420
ttagtggca  tggtccatc  gctgcaagg  agtttgtag  tgaaggaat  aaaacacta  480
aagatctca  aaaaaatga  gataaattg  accatcatc  gcgaattgg  ctgaaatat  540
ttggggact  tgaaaaaag  attcctcgt  aagagatgt  acaaatgca  gatattgtt  600
taaatgaag  taaaaaagt  gattctgaa  acattgcta  agtctgtgg  agtttcaga  660
gaggtgcag  gtccagtgg  gacatggat  ttctcctga  ccatcccag  ttcacttca  720
aatcaacca  acagccaaa  ctgttacat  aggttgtgg  gcagttaca  aaggttcat  780
ttatcacag  tacccgttc  aagggtgag  caaagttca  gggtgtttg  cagcttccc  840
gtaaaaatg  tgaaaaaga  tatccacac  gaagaattg  tatcaggtt  tacccaaaa  900
atcagtatt  ctgtggtgt  ctctatttc  ctgggagtg  tattttcaa  aagaatatg  960
gagctcatg  caaggaaaa  ggtttcaca  tcaatgagt  caccatccg  cccttggga  1020
tcactggag  tgcaggaga  cccctgcca  tggatagtg  aaaagacat  tttgattac  1080
tccagtgga  ataccggga  cccaaggac  ggagcgaat  aggcctgta  cctccctgg  1140
gcagacaca  cccaatggg  cttaattta  ttcttaacc  ttgctatgt  agggtcttt  1200
gtgttttta  atgattgtt  cttcttcat  cttttgctt  caatgtagt  aataaaacc  1259



<210> 2422
<211> 334
<212> PRT
<213> Homo sapiens
<308> P06746
<400> 2422

Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr Asp 
  1               5                  10                  15
Met Leu Thr Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala Ile 
             20                  25                  30
His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys Tyr 
         35                  40                  45
Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly Val 
     50                  55                  60
Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly Lys 
 65                  70                  75                  80
Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser Ile 
                 85                  90                  95
Asn Phe Leu Thr Arg Val Ser Gly Ile Gly Pro Ser Ala Ala Arg Lys 
             100                105                110
Phe Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn Glu 
         115                120                125
Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys Tyr Phe Gly Asp 
     130                135                140
Phe Glu Lys Arg Ile Pro Arg Glu Glu Met Leu Gln Met Gln Asp Ile 
 145                150                155                160
Val Leu Asn Glu Val Lys Lys Val Asp Ser Glu Tyr Ile Ala Thr Val 
                 165                170                175
Cys Gly Ser Phe Arg Arg Gly Ala Glu Ser Ser Gly Asp Met Asp Val 
             180                185                190
Leu Leu Thr His Pro Ser Phe Thr Ser Glu Ser Thr Lys Gln Pro Lys 
         195                200                205
Leu Leu His Gln Val Val Glu Gln Leu Gln Lys Val His Phe Ile Thr 
     210                215                220
Asp Thr Leu Ser Lys Gly Glu Thr Lys Phe Met Gly Val Cys Gln Leu 
 225                230                235                240
Pro Ser Lys Asn Asp Glu Lys Glu Tyr Pro His Arg Arg Ile Asp Ile 
                 245                250                255
Arg Leu Ile Pro Lys Asp Gln Tyr Tyr Cys Gly Val Leu Tyr Phe Thr 
             260                265                270
Gly Ser Asp Ile Phe Asn Lys Asn Met Arg Ala His Ala Leu Glu Lys 
         275                280                285
Gly Phe Thr Ile Asn Glu Tyr Thr Ile Arg Pro Leu Gly Val Thr Gly 
     290                295                300
Val Ala Gly Glu Pro Leu Pro Val Asp Ser Glu Lys Asp Ile Phe Asp 
 305                310                315                320
Tyr Ile Gln Trp Lys Tyr Arg Glu Pro Lys Asp Arg Ser Glu 
                 325                330



<210> 2423
<211> 1866
<212> DNA
<213> Rattus norvegicus
<308> J02791
<400> 2423

agagccaac  gagcaggaa  gcatcatgg  agcagcgct  cgcagaggc  acaaggtcc  60
gagaagtgt  tctcatttt  agtgtcgag  acaacacac  aaaccatct  tcaagcagg  120
gccgggact  gggtttagc  tcgagttga  ggagcagca  aaagagttt  aaacaattg  180
tcggaagtt  gccagagag  aaataatcc  ggtcgcccc  gactacgat  aaagcgggg  240
atacccgtt  cctctcatc  agagagcct  ggaacttgg  ttgatcaac  cacacattc  300
ggagagttg  ggtggtctt  gcctgggaa  ttttgatgc  tgtttaatt  cggaagagt  360
ggcatatgg  tgtacaggg  tgcagactg  tattgaagc  aattctttg  ggcaaatgc  420
tgtgattat  gctggaaat  atcaacaga  gaagaagta  ttggggagg  tgacggagc  480
gccgatgat  tgtgcctac  gcgtgacag  accctcagc  ggctctgat  tggcgggca  540
taagaccaa  gcagagaag  agggtgatg  atatgtcat  aatggccag  agatgtgga  600
aaccaacgg  ggaaaggcc  actggtatt  tgtattgac  cgatctaac  cagatccta  660
agtacctgc  agtaaagcc  tcaccggat  catcgtgga  gccgacacc  cgggaatac  720
catcggaaa  aaggaacta  acatgggtc  gcggtgctc  gacaccaga  gaatcacct  780
cgaagatgt  agagtgcct  aggaaaatg  gttaattgg  gaaggagca  gtttcaaga  840
tgcaatggg  gcttttgat  gaaccaggc  gacggtcgc  gctggtgct  tcgggctag  900
ccagagagc  ctggacgaa  ctactaagt  tgccctgga  aggaaaaca  ttggaaagc  960
gctagtgga  caccaagga  tttcatttc  gctcgcaga  atggcgatg  aagttgaac  1020
ggccagact  agttaccag  gagcagcct  ggaggttga  tccggccgc  ggaacacgt  1080
ctttgcctc  attgcgaag  cctttgctg  agatattgc  aaccagctc  ctaccgatg  1140
tgtgcagat  ttcggaggc  atggattca  cactgagta  ccagtagaa  agctgatgc  1200
ggacgccaa  atctatcag  tttacgaag  tactgcaca  attcagagg  tgatcatag  1260
tcgtgagca  attgaaaag  ataaaaatt  acagaaatt  ctatcgaac  atgcttcac  1320
ctcatgtaa  tacgctcag  gcactgttg  tgcttcagg  ggaaagggc  ttacttgtc  1380
tcccacaga  atgagataa  agacgcgtg  cacagatct  tgcaatggg  tcccacggc  1440
gagggtgcc  ctgttgagt  ccacagtga  cctttctag  taggtttgg  tttggacag  1500
gagtggtca  tccttggcc  cgaattgtg  taatttgct  cttgatcac  tgagatgga  1560
aaataccct  gagttctaa  gctcattca  gtgacaaga  aggtagcct  tcacgaaag  1620
actcaggat  ctacacaga  actgaggaa  gtggcggat  ggacccatc  cactgtgaa  1680
agagagcat  tctgtgctg  gctgtttca  aattttgat  atatttccc  tgtattgca  1740
aagagtaaa  aagtttata  gcattttct  ccattataa  actaaaaac  ttctggaaa  1800
tcttaattc  gaactggca  tttatttgt  ttgattaca  tgattcaat  aagctagcc  1860
taactt  1866



<210> 2424
<211> 421
<212> PRT
<213> Rattus norvegicus
<308> P08503
<400> 2424

Met Ala Ala Ala Leu Arg Arg Gly Tyr Lys Val Leu Arg Ser Val Ser 
  1               5                  10                  15
His Phe Glu Cys Arg Ala Gln His Thr Lys Pro Ser Leu Lys Gln Glu 
             20                  25                  30
Pro Gly Leu Gly Phe Ser Phe Glu Leu Thr Glu Gln Gln Lys Glu Phe 
         35                  40                  45
Gln Thr Ile Ala Arg Lys Phe Ala Arg Glu Glu Ile Ile Pro Val Ala 
     50                  55                  60
Pro Asp Tyr Asp Lys Ser Gly Glu Tyr Pro Phe Pro Leu Ile Lys Arg 
 65                  70                  75                  80
Ala Trp Glu Leu Gly Leu Ile Asn Thr His Ile Pro Glu Ser Cys Gly 
                 85                  90                  95
Gly Leu Gly Leu Gly Thr Phe Asp Ala Cys Leu Ile Thr Glu Glu Leu 
             100                105                110
Ala Tyr Gly Cys Thr Gly Val Gln Thr Ala Ile Glu Ala Asn Ser Leu 
         115                120                125
Gly Gln Met Pro Val Ile Ile Ala Gly Asn Asp Gln Gln Lys Lys Lys 
     130                135                140
Tyr Leu Gly Arg Met Thr Glu Gln Pro Met Met Cys Ala Tyr Cys Val 
 145                150                155                160
Thr Glu Pro Ser Ala Gly Ser Asp Val Ala Gly Ile Lys Thr Lys Ala 
                 165                170                175
Glu Lys Lys Gly Asp Glu Tyr Val Ile Asn Gly Gln Lys Met Trp Ile 
             180                185                190
Thr Asn Gly Gly Lys Ala Asn Trp Tyr Phe Val Leu Thr Arg Ser Asn 
         195                200                205
Pro Asp Pro Lys Val Pro Ala Ser Lys Ala Phe Thr Gly Phe Ile Val 
     210                215                220
Glu Ala Asp Thr Pro Gly Ile His Ile Gly Lys Lys Glu Leu Asn Met 
 225                230                235                240
Gly Gln Arg Cys Ser Asp Thr Arg Gly Ile Thr Phe Glu Asp Val Arg 
                 245                250                255
Val Pro Lys Glu Asn Val Leu Ile Gly Glu Gly Ala Gly Phe Lys Ile 
             260                265                270
Ala Met Gly Ala Phe Asp Arg Thr Arg Pro Thr Val Ala Ala Gly Ala 
         275                280                285
Val Gly Leu Ala Gln Arg Ala Leu Asp Glu Ala Thr Lys Tyr Ala Leu 
     290                295                300
Asp Arg Lys Thr Phe Gly Lys Leu Leu Val Glu His Gln Gly Val Ser 
 305                310                315                320
Phe Leu Leu Ala Glu Met Ala Met Lys Val Glu Leu Ala Arg Leu Ser 
                 325                330                335
Tyr Gln Arg Ala Ala Trp Glu Val Asp Ser Gly Arg Arg Asn Thr Tyr 
             340                345                350
Phe Ala Ser Ile Ala Lys Ala Phe Ala Gly Asp Ile Ala Asn Gln Leu 
         355                360                365
Ala Thr Asp Ala Val Gln Ile Phe Gly Gly Tyr Gly Phe Asn Thr Glu 
     370                375                380
Tyr Pro Val Glu Lys Leu Met Arg Asp Ala Lys Ile Tyr Gln Ile Tyr 
 385                390                395                400
Glu Gly Thr Ala Gln Ile Gln Arg Leu Ile Ile Ala Arg Glu His Ile 
                 405                410                415
Glu Lys Tyr Lys Asn 
             420



<210> 2425
<211> 2019
<212> DNA
<213> Homo sapiens
<308> M16827
<400> 2425

ccggaacgg  gagccaaca  ggcagcggg  ttcgggcga  gctgcaggg  cctgagaag  60
atttctcgt  ttcattgga  atcacagca  acaaaagcc  atcgacaac  tgaaccagg  120
ttaggattt  gttttgagt  caccgaaca  cagaaagaa  ttcaagcta  tgctcgtaa  180
tttgccaga  aggaaatca  cccagtggc  gcagaatat  ataaaactg  tgaatatcc  240
gtcccccta  ttagaagag  ctgggaact  ggtttaatg  acacacaca  tccagagaa  300
tgtggaggt  ttggacttg  aacttttga  gcttgttta  ttagtgaag  attggctta  360
ggatgtaca  gggttcaga  tgctattga  ggaaattct  tggggcaaa  gcctattat  420
attgctgga  atgatcaac  aaagaagaa  tatttgggg  gaatgactg  ggagccatt  480
atgtgtgct  attgtgtaa  agaacctgg  gcaggctct  atgtagctg  tataaagac  540
aaagcagaa  agaaaggag  tgagtatat  attaatggt  agaagatgt  gataaccaa  600
ggaggaaaa  ctaattggt  ttttttatt  gcacgttct  atccagatc  taaagctcc  660
gctaataaa  cctttactg  attcattgt  gaagcagat  ccccaggaa  tcagattgg  720
agaaaggaa  taaacatgg  ccagcgatg  tcagatact  gaggaattg  cttcgaaga  780
gtgaaagtg  ctaaagaaa  tgttttaat  ggtgacgga  ctggtttca  agttgcaat  840
ggagctttt  ataaaacca  acctgtagt  gctgctggt  ctgttggat  agcacaaag  900
gctttggat  aagctacca  gtatgccct  gaaaggaaa  ctttcggaa  gctacttgt  960
gagcaccaa  caatatcat  tatgctggc  gaaatggca  tgaaagttg  actagctag  1020
atgagttac  agagagcag  ttgggaggt  gattctggt  gtcgaaata  ctattatgc  1080
tctattgca  aggcatttg  tggagatat  gcaaatcag  tagctactg  tgctgtgca  1140
atacttgga  gcaatggat  taatacaga  tatcctgta  aaaaactaa  gagggatgc  1200
aaaatctat  agatttatg  aggtacttc  caaattcaa  gacttattg  agcccgtga  1260
cacattgac  agtacaaaa  ttaaaaaaa  tactgtaga  atattgaat  actagaaca  1320
aagccactg  ttcagctcc  gaaaaaaga  agggcttta  cgttttttc  agtgaaaac  1380
aatcctctt  tattaaatc  aagcaactg  ttattatag  agtttatac  tttgcttaa  1440
tctgttatg  ctcttaagc  ggtttggtt  ttattaaaa  gatgtgttt  ctttagtac  1500
actttactt  aattacatt  acctagaaa  ctacatagg  tattttgat  tcttaagat  1560
aatgtagca  aaatttctt  gaattttat  tttgtaatg  cagaaaagt  ggcttagaa  1620
gtattcaag  tgttacaaa  tttacattt  gaaaatatt  tagtatttg  atactgtca  1680
cttgacagt  actttgtag  cttaatggt  ttattaaag  tctttttat  gcagtttgg  1740
aagcatttg  gaaactttc  gtttggcac  gaaacagtc  aaattttga  attcatatt  1800
tcctatttt  cagctacaa  aactttctt  aaaatctta  ttaattctg  gcccatatt  1860
cacttacct  atttaaaat  aatcaataa  gcttgcctt  aattatttt  atatgactg  1920
tggtctcta  gtagccttt  gtctattgt  cacaatctc  tttcatatg  ttgcatttt  1980
gcaaagaac  taataaaat  gttcagtgc  tattatcat  2019



<210> 2426
<211> 421
<212> PRT
<213> Homo sapiens
<308> P11310
<400> 2426

Met Ala Ala Gly Phe Gly Arg Cys Cys Arg Val Leu Arg Ser Ile Ser 
  1               5                  10                  15
Arg Phe His Trp Arg Ser Gln His Thr Lys Ala Asn Arg Gln Arg Glu 
             20                  25                  30
Pro Gly Leu Gly Phe Ser Phe Glu Phe Thr Glu Gln Gln Lys Glu Phe 
         35                  40                  45
Gln Ala Thr Ala Arg Lys Phe Ala Arg Glu Glu Ile Ile Pro Val Ala 
     50                  55                  60
Ala Glu Tyr Asp Lys Thr Gly Glu Tyr Pro Val Pro Leu Ile Arg Arg 
 65                  70                  75                  80
Ala Trp Glu Leu Gly Leu Met Asn Thr His Ile Pro Glu Asn Cys Gly 
                 85                  90                  95
Gly Leu Gly Leu Gly Thr Phe Asp Ala Cys Leu Ile Ser Glu Glu Leu 
             100                105                110
Ala Tyr Gly Cys Thr Gly Val Gln Thr Ala Ile Glu Gly Asn Ser Leu 
         115                120                125
Gly Gln Met Pro Ile Ile Ile Ala Gly Asn Asp Gln Gln Lys Lys Lys 
     130                135                140
Tyr Leu Gly Arg Met Thr Glu Glu Pro Leu Met Cys Ala Tyr Cys Val 
 145                150                155                160
Thr Glu Pro Gly Ala Gly Ser Asp Val Ala Gly Ile Lys Thr Lys Ala 
                 165                170                175
Glu Lys Lys Gly Asp Glu Tyr Ile Ile Asn Gly Gln Lys Met Trp Ile 
             180                185                190
Thr Asn Gly Gly Lys Ala Asn Trp Tyr Phe Leu Leu Ala Arg Ser Asp 
         195                200                205
Pro Asp Pro Lys Ala Pro Ala Asn Lys Ala Phe Thr Gly Phe Ile Val 
     210                215                220
Glu Ala Asp Thr Pro Gly Ile Gln Ile Gly Arg Lys Glu Leu Asn Met 
 225                230                235                240
Gly Gln Arg Cys Ser Asp Thr Arg Gly Ile Val Phe Glu Asp Val Lys 
                 245                250                255
Val Pro Lys Glu Asn Val Leu Ile Gly Asp Gly Ala Gly Phe Lys Val 
             260                265                270
Ala Met Gly Ala Phe Asp Lys Thr Arg Pro Val Val Ala Ala Gly Ala 
         275                280                285
Val Gly Leu Ala Gln Arg Ala Leu Asp Glu Ala Thr Lys Tyr Ala Leu 
     290                295                300
Glu Arg Lys Thr Phe Gly Lys Leu Leu Val Glu His Gln Ala Ile Ser 
 305                310                315                320
Phe Met Leu Ala Glu Met Ala Met Lys Val Glu Leu Ala Arg Met Ser 
                 325                330                335
Tyr Gln Arg Ala Ala Trp Glu Val Asp Ser Gly Arg Arg Asn Thr Tyr 
             340                345                350
Tyr Ala Ser Ile Ala Lys Ala Phe Ala Gly Asp Ile Ala Asn Gln Leu 
         355                360                365
Ala Thr Asp Ala Val Gln Ile Leu Gly Gly Asn Gly Phe Asn Thr Glu 
     370                375                380
Tyr Pro Val Glu Lys Leu Met Arg Asp Ala Lys Ile Tyr Gln Ile Tyr 
 385                390                395                400
Glu Gly Thr Ser Gln Ile Gln Arg Leu Ile Val Ala Arg Glu His Ile 
                 405                410                415
Asp Lys Tyr Lys Asn 
             420



<210> 2427
<211> 1639
<212> DNA
<213> Rattus norvegicus
<308> J02827
<400> 2427

tccgcggcc  agatctgga  gccgagccg  ggcctgcgc  aggctgccc  cttgctgtt  60
gggcgacct  gggctcggg  cttggctag  ttccacccc  gcaggcagc  gcaacagca  120
ttcccatcc  tggatgaca  gccccagtt  ccaggggcc  ctgcagagt  tgtagacaa  180
cttgagttc  tccagccca  tgtcatctc  ggcatcccc  tctaccgcg  catggaccg  240
cagggccag  tcatcaacc  cagtgaaga  ccccacctg  cccaggagg  ggtcctgaa  300
ttgtacagg  gcatgacgc  gctcaacac  atggaccgc  ttctctatg  gtcccagcg  360
cagggccgg  tctccttct  catgaccaa  tatggcgag  aggggacac  tgtggggag  420
gccgctgcc  tggagcgaa  ggacctggt  tttggccag  accgggagg  aggtgtgct  480
atgtaccgg  actacccgc  ggagctgtt  atggcccag  gctacggca  cgtgagtga  540
ccaggcaag  gacgccaga  gcccgttca  tacggctgc  aggagcgtc  cttcgtcac  600
atttcctct  cactggcta  gcagatccc  caggcggta  gggcagcct  tgctgccaa  660
cgggccaat  ccaatcaga  cgtgatctg  tactttggc  agggggcag  cagtgaagg  720
gatgcccac  ccggtttca  ttttgctgc  accttggag  gtcctatca  cttcttctg  780
cggaacaat  gctatgcca  ctccacacc  acctctgag  agtaccgtg  ggatggcat  840
gcggctcgg  gccctgggt  tggcatcat  tcaatccgt  tggacggca  cgatgtgtt  900
gcggtgtac  atgccacta  ggaggcccg  cggcgggct  tggctgaga  ccagccctt  960
ctcattgag  ccatgacct  caggatcgg  caccacagc  ccagtgacg  cagctctgc  1020
taccgttcg  tggatgagg  caattactg  gacaagcag  accacccga  ctcgagact  1080
aggcagtac  tgctgaacc  gggttggtg  gatgaggaa  aggagaagg  ctggcggaa  1140
cagtcacga  agaaggtga  ggaggcctt  gaacaggct  agcggaagc  aaagcccaa  1200
ccaagcctc  tcttctccg  tgtgtacca  gagatgcct  cccagctgc  caggcagca  1260
gagtccctg  ctcggcacc  gcagaccta  ggggagcac  accccctgg  ccactttga  1320
aagtgaggc  ctaaccacc  caaggtgtc  tgctctgag  ggagctggg  ggcggcagg  1380
cgctgcccc  cgctgctaa  cagtgctgc  gacgtgctg  gcagccagt  tggcacgca  1440
tgcggctcc  ccaggctac  tcactgggg  accacattt  cagccattg  tgcagctcc  1500
tcactccct  cacctgtta  agtgccttt  aggggtggg  aggaaccag  gccagggca  1560
accctttgg  agggtggcc  tggatttgc  cagagaaat  gctgattgg  agagtaagt  1620
aaccacagc  ctgcctttg  1639



<210> 2428
<211> 441
<212> PRT
<213> Rattus norvegicus
<308> P11960
<400> 2428

Ser Ala Ala Lys Ile Trp Arg Pro Ser Arg Gly Leu Arg Gln Ala Ala 
  1               5                  10                  15
Leu Leu Leu Leu Gly Arg Pro Gly Ala Arg Gly Leu Ala Arg Phe His 
             20                  25                  30
Pro Ser Arg Gln Gln Gln Gln Gln Phe Pro Ser Leu Asp Asp Lys Pro 
         35                  40                  45
Gln Phe Pro Gly Ala Ser Ala Glu Phe Val Asp Lys Leu Glu Phe Ile 
     50                  55                  60
Gln Pro Asn Val Ile Ser Gly Ile Pro Ile Tyr Arg Val Met Asp Arg 
 65                  70                  75                  80
Gln Gly Gln Ile Ile Asn Pro Ser Glu Asp Pro His Leu Pro Gln Glu 
                 85                  90                  95
Glu Val Leu Lys Leu Tyr Arg Ser Met Thr Leu Leu Asn Thr Met Asp 
             100                105                110
Arg Ile Leu Tyr Glu Ser Gln Arg Gln Gly Arg Ile Ser Phe Tyr Met 
         115                120                125
Thr Asn Tyr Gly Glu Glu Gly Thr His Val Gly Ser Ala Ala Ala Leu 
     130                135                140
Glu Arg Thr Asp Leu Val Phe Gly Gln Tyr Arg Glu Ala Gly Val Leu 
 145                150                155                160
Met Tyr Arg Asp Tyr Pro Leu Glu Leu Phe Met Ala Gln Cys Tyr Gly 
                 165                170                175
Asn Val Ser Asp Pro Gly Lys Gly Arg Gln Met Pro Val His Tyr Gly 
             180                185                190
Cys Lys Glu Arg His Phe Val Thr Ile Ser Ser Pro Leu Ala Thr Gln 
         195                200                205
Ile Pro Gln Ala Val Gly Ala Ala Tyr Ala Ala Lys Arg Ala Asn Ala 
     210                215                220
Asn Gln Ile Val Ile Cys Tyr Phe Gly Glu Gly Ala Ala Ser Glu Gly 
 225                230                235                240
Asp Ala His Ala Gly Phe Asn Phe Ala Ala Thr Leu Glu Cys Pro Ile 
                 245                250                255
Ile Phe Phe Cys Arg Asn Asn Gly Tyr Ala Ile Ser Thr Pro Thr Ser 
             260                265                270
Glu Gln Tyr Arg Gly Asp Gly Ile Ala Ala Arg Gly Pro Gly Tyr Gly 
         275                280                285
Ile Met Ser Ile Arg Val Asp Gly Asn Asp Val Phe Ala Val Tyr Asn 
     290                295                300
Ala Thr Lys Glu Ala Arg Arg Arg Ala Val Ala Glu Asn Gln Pro Phe 
 305                310                315                320
Leu Ile Glu Ala Met Thr Tyr Arg Ile Gly His His Ser Thr Ser Asp 
                 325                330                335
Asp Ser Ser Ala Tyr Arg Ser Val Asp Glu Val Asn Tyr Trp Asp Lys 
             340                345                350
Gln Asp His Pro Ile Ser Arg Leu Arg Gln Tyr Leu Leu Asn Gln Gly 
         355                360                365
Trp Trp Asp Glu Glu Gln Glu Lys Ala Trp Arg Lys Gln Ser Arg Lys 
     370                375                380
Lys Val Met Glu Ala Phe Glu Gln Ala Glu Arg Lys Leu Lys Pro Asn 
 385                390                395                400
Pro Ser Leu Leu Phe Ser Asp Val Tyr Gln Glu Met Pro Ala Gln Leu 
                 405                410                415
Arg Arg Gln Gln Glu Ser Leu Ala Arg His Leu Gln Thr Tyr Gly Glu 
             420                425                430
His Tyr Pro Leu Asp His Phe Asp Lys 
         435                440



<210> 2429
<211> 1530
<212> DNA
<213> Homo sapiens
<308> M22221
<400> 2429

atccagccc  acgtcatct  tggaatccc  atctaccgc  tcatggacc  gcaaggcca  60
atcatcaac  ccagcgagg  cccccacct  ccgaaggag  aggtgctga  gctctacaa  120
agcatgaca  tgcttaaca  catggaccg  atcctctat  agtctcagc  gcagggccg  180
atctccttc  acatgacca  ctatggtga  gagggcacg  acgtgggga  tgccgccgc  240
ctggacaac  cggacctgg  gtttggcca  taccgggag  caggtgtgc  gatgtatcg  300
gactacccc  tggaactat  catggccca  tgctatggc  acatcagtg  cttgggcaa  360
gggcgccag  tgcctgtcc  ctacggctg  aaggaacgc  acttcgtca  tatctcctc  420
ccactggcc  cgcagatcc  tcaggcggt  ggggcggcg  acgcagcca  gcgggccaa  480
gccaacagg  tcgtcatct  ttacttcgg  gagggggca  ccagtgagg  ggacgccca  540
gacggcttc  acttcgctg  cacacttga  tgccccatc  tcttcttct  ccggaacaa  600
ggctacgcc  tctccacgc  cacctctga  cagtatcgc  gcgatggca  tgcagcacg  660
ggccccggg  atggcatca  gtcaatccg  gtggatggt  atgatgtgt  tgccgtata  720
aacgccact  aagaggccc  acggcgggc  gtggcagag  accagccct  tctcatcga  780
gccatgacc  acaggatcg  gcaccacag  accagtgac  acagttcag  gtaccgctc  840
gtggatgag  tcaattact  ggataaaca  gaccacccc  tctcccggc  gcggcacta  900
ctgctgagc  aaggctggt  ggatgagga  caggagaag  cctggagga  gcagtcccg  960
aggaaggtg  tggaggcct  tgagcaggc  gagcggaag  ccaaaccca  ccccaacct  1020
ctcttctca  acgtgtatc  ggagatgcc  gcccagctc  gcaagcagc  ggagtctct  1080
gcccgccac  tgcagacct  cggggagca  tacccactg  atcacttcg  taagtgaga  1140
ctgctcagc  cacccccac  catcctcag  taccccgag  ggtagcccc  ctctaaggg  1200
agcaggggg  cctgacagc  caccactgt  ttccccagt  agctccctc  aaaatactc  1260
gcggccagg  cggctgcca  tcttcaccc  tgctcctcc  ggctgttac  ttgtcaggg  1320
acagcatct  cagcagttg  tgaggctcc  tcagccccc  cttcacctg  tgttacagt  1380
ccttctccc  ggggctggg  gagggcaca  tcaggacta  aagcccctc  gggcatggg  1440
tggacatgg  aggtcagcc  gtggaactt  cgcaggtgc  agtggccag  agaggtcac  1500
aataaactg  atctctgcg  ctggctctct  1530



<210> 2430
<211> 445
<212> PRT
<213> Homo sapiens
<308> P12694
<400> 2430

Met Ala Val Ala Ile Ala Ala Ala Arg Val Trp Arg Leu Asn Arg Gly 
  1               5                  10                  15
Leu Ser Gln Ala Ala Leu Leu Leu Leu Arg Gln Pro Gly Ala Arg Gly 
             20                  25                  30
Leu Ala Arg Ser His Pro Pro Arg Gln Gln Gln Gln Phe Ser Ser Leu 
         35                  40                  45
Asp Asp Lys Pro Gln Phe Pro Gly Ala Ser Ala Glu Phe Ile Asp Lys 
     50                  55                  60
Leu Glu Phe Ile Gln Pro Asn Val Ile Ser Gly Ile Pro Ile Tyr Arg 
 65                  70                  75                  80
Val Met Asp Arg Gln Gly Gln Ile Ile Asn Pro Ser Glu Asp Pro His 
                 85                  90                  95
Leu Pro Lys Glu Lys Val Leu Lys Leu Tyr Lys Ser Met Thr Leu Leu 
             100                105                110
Asn Thr Met Asp Arg Ile Leu Tyr Glu Ser Gln Arg Gln Gly Arg Ile 
         115                120                125
Ser Phe Tyr Met Thr Asn Tyr Gly Glu Glu Gly Thr His Val Gly Ser 
     130                135                140
Ala Ala Ala Leu Asp Asn Thr Asp Leu Val Phe Gly Gln Tyr Arg Glu 
 145                150                155                160
Ala Gly Val Leu Met Tyr Arg Asp Tyr Pro Leu Glu Leu Phe Met Ala 
                 165                170                175
Gln Cys Tyr Gly Asn Ile Ser Asp Leu Gly Lys Gly Arg Gln Met Pro 
             180                185                190
Val His Tyr Gly Cys Lys Glu Arg His Phe Val Thr Ile Ser Ser Pro 
         195                200                205
Leu Ala Thr Gln Ile Pro Gln Ala Val Gly Ala Ala Tyr Ala Ala Lys 
     210                215                220
Arg Ala Asn Ala Asn Arg Val Val Ile Cys Tyr Phe Gly Glu Gly Ala 
 225                230                235                240
Ala Ser Glu Gly Asp Ala His Ala Gly Phe Asn Phe Ala Ala Thr Leu 
                 245                250                255
Glu Cys Pro Ile Ile Phe Phe Cys Arg Asn Asn Gly Tyr Ala Ile Ser 
             260                265                270
Thr Pro Thr Ser Glu Gln Tyr Arg Gly Asp Gly Ile Ala Ala Arg Gly 
         275                280                285
Pro Gly Tyr Gly Ile Met Ser Ile Arg Val Asp Gly Asn Asp Val Phe 
     290                295                300
Ala Val Tyr Asn Ala Thr Lys Glu Ala Arg Arg Arg Ala Val Ala Glu 
 305                310                315                320
Asn Gln Pro Phe Leu Ile Glu Ala Met Thr Tyr Arg Ile Gly His His 
                 325                330                335
Ser Thr Ser Asp Asp Ser Ser Ala Tyr Arg Ser Val Asp Glu Val Asn 
             340                345                350
Tyr Trp Asp Lys Gln Asp His Pro Ile Ser Arg Leu Arg His Tyr Leu 
         355                360                365
Leu Ser Gln Gly Trp Trp Asp Glu Glu Gln Glu Lys Ala Trp Arg Lys 
     370                375                380
Gln Ser Arg Arg Lys Val Met Glu Ala Phe Glu Gln Ala Glu Arg Lys 
 385                390                395                400
Pro Lys Pro Asn Pro Asn Leu Leu Phe Ser Asp Val Tyr Gln Glu Met 
                 405                410                415
Pro Ala Gln Leu Arg Lys Gln Gln Glu Ser Leu Ala Arg His Leu Gln 
             420                425                430
Thr Tyr Gly Glu His Tyr Pro Leu Asp His Phe Asp Lys 
         435                440                445



<210> 2431
<211> 1639
<212> DNA
<213> Rattus norvegicus
<308> J02827
<400> 2431

tccgcggcc  agatctgga  gccgagccg  ggcctgcgc  aggctgccc  cttgctgtt  60
gggcgacct  gggctcggg  cttggctag  ttccacccc  gcaggcagc  gcaacagca  120
ttcccatcc  tggatgaca  gccccagtt  ccaggggcc  ctgcagagt  tgtagacaa  180
cttgagttc  tccagccca  tgtcatctc  ggcatcccc  tctaccgcg  catggaccg  240
cagggccag  tcatcaacc  cagtgaaga  ccccacctg  cccaggagg  ggtcctgaa  300
ttgtacagg  gcatgacgc  gctcaacac  atggaccgc  ttctctatg  gtcccagcg  360
cagggccgg  tctccttct  catgaccaa  tatggcgag  aggggacac  tgtggggag  420
gccgctgcc  tggagcgaa  ggacctggt  tttggccag  accgggagg  aggtgtgct  480
atgtaccgg  actacccgc  ggagctgtt  atggcccag  gctacggca  cgtgagtga  540
ccaggcaag  gacgccaga  gcccgttca  tacggctgc  aggagcgtc  cttcgtcac  600
atttcctct  cactggcta  gcagatccc  caggcggta  gggcagcct  tgctgccaa  660
cgggccaat  ccaatcaga  cgtgatctg  tactttggc  agggggcag  cagtgaagg  720
gatgcccac  ccggtttca  ttttgctgc  accttggag  gtcctatca  cttcttctg  780
cggaacaat  gctatgcca  ctccacacc  acctctgag  agtaccgtg  ggatggcat  840
gcggctcgg  gccctgggt  tggcatcat  tcaatccgt  tggacggca  cgatgtgtt  900
gcggtgtac  atgccacta  ggaggcccg  cggcgggct  tggctgaga  ccagccctt  960
ctcattgag  ccatgacct  caggatcgg  caccacagc  ccagtgacg  cagctctgc  1020
taccgttcg  tggatgagg  caattactg  gacaagcag  accacccga  ctcgagact  1080
aggcagtac  tgctgaacc  gggttggtg  gatgaggaa  aggagaagg  ctggcggaa  1140
cagtcacga  agaaggtga  ggaggcctt  gaacaggct  agcggaagc  aaagcccaa  1200
ccaagcctc  tcttctccg  tgtgtacca  gagatgcct  cccagctgc  caggcagca  1260
gagtccctg  ctcggcacc  gcagaccta  ggggagcac  accccctgg  ccactttga  1320
aagtgaggc  ctaaccacc  caaggtgtc  tgctctgag  ggagctggg  ggcggcagg  1380
cgctgcccc  cgctgctaa  cagtgctgc  gacgtgctg  gcagccagt  tggcacgca  1440
tgcggctcc  ccaggctac  tcactgggg  accacattt  cagccattg  tgcagctcc  1500
tcactccct  cacctgtta  agtgccttt  aggggtggg  aggaaccag  gccagggca  1560
accctttgg  agggtggcc  tggatttgc  cagagaaat  gctgattgg  agagtaagt  1620
aaccacagc  ctgcctttg  1639



<210> 2432
<211> 441
<212> PRT
<213> Rattus norvegicus
<308> P11960
<400> 2432

Ser Ala Ala Lys Ile Trp Arg Pro Ser Arg Gly Leu Arg Gln Ala Ala 
  1               5                  10                  15
Leu Leu Leu Leu Gly Arg Pro Gly Ala Arg Gly Leu Ala Arg Phe His 
             20                  25                  30
Pro Ser Arg Gln Gln Gln Gln Gln Phe Pro Ser Leu Asp Asp Lys Pro 
         35                  40                  45
Gln Phe Pro Gly Ala Ser Ala Glu Phe Val Asp Lys Leu Glu Phe Ile 
     50                  55                  60
Gln Pro Asn Val Ile Ser Gly Ile Pro Ile Tyr Arg Val Met Asp Arg 
 65                  70                  75                  80
Gln Gly Gln Ile Ile Asn Pro Ser Glu Asp Pro His Leu Pro Gln Glu 
                 85                  90                  95
Glu Val Leu Lys Leu Tyr Arg Ser Met Thr Leu Leu Asn Thr Met Asp 
             100                105                110
Arg Ile Leu Tyr Glu Ser Gln Arg Gln Gly Arg Ile Ser Phe Tyr Met 
         115                120                125
Thr Asn Tyr Gly Glu Glu Gly Thr His Val Gly Ser Ala Ala Ala Leu 
     130                135                140
Glu Arg Thr Asp Leu Val Phe Gly Gln Tyr Arg Glu Ala Gly Val Leu 
 145                150                155                160
Met Tyr Arg Asp Tyr Pro Leu Glu Leu Phe Met Ala Gln Cys Tyr Gly 
                 165                170                175
Asn Val Ser Asp Pro Gly Lys Gly Arg Gln Met Pro Val His Tyr Gly 
             180                185                190
Cys Lys Glu Arg His Phe Val Thr Ile Ser Ser Pro Leu Ala Thr Gln 
         195                200                205
Ile Pro Gln Ala Val Gly Ala Ala Tyr Ala Ala Lys Arg Ala Asn Ala 
     210                215                220
Asn Gln Ile Val Ile Cys Tyr Phe Gly Glu Gly Ala Ala Ser Glu Gly 
 225                230                235                240
Asp Ala His Ala Gly Phe Asn Phe Ala Ala Thr Leu Glu Cys Pro Ile 
                 245                250                255
Ile Phe Phe Cys Arg Asn Asn Gly Tyr Ala Ile Ser Thr Pro Thr Ser 
             260                265                270
Glu Gln Tyr Arg Gly Asp Gly Ile Ala Ala Arg Gly Pro Gly Tyr Gly 
         275                280                285
Ile Met Ser Ile Arg Val Asp Gly Asn Asp Val Phe Ala Val Tyr Asn 
     290                295                300
Ala Thr Lys Glu Ala Arg Arg Arg Ala Val Ala Glu Asn Gln Pro Phe 
 305                310                315                320
Leu Ile Glu Ala Met Thr Tyr Arg Ile Gly His His Ser Thr Ser Asp 
                 325                330                335
Asp Ser Ser Ala Tyr Arg Ser Val Asp Glu Val Asn Tyr Trp Asp Lys 
             340                345                350
Gln Asp His Pro Ile Ser Arg Leu Arg Gln Tyr Leu Leu Asn Gln Gly 
         355                360                365
Trp Trp Asp Glu Glu Gln Glu Lys Ala Trp Arg Lys Gln Ser Arg Lys 
     370                375                380
Lys Val Met Glu Ala Phe Glu Gln Ala Glu Arg Lys Leu Lys Pro Asn 
 385                390                395                400
Pro Ser Leu Leu Phe Ser Asp Val Tyr Gln Glu Met Pro Ala Gln Leu 
                 405                410                415
Arg Arg Gln Gln Glu Ser Leu Ala Arg His Leu Gln Thr Tyr Gly Glu 
             420                425                430
His Tyr Pro Leu Asp His Phe Asp Lys 
         435                440



<210> 2433
<211> 1530
<212> DNA
<213> Homo sapiens
<308> M22221
<400> 2433

atccagccc  acgtcatct  tggaatccc  atctaccgc  tcatggacc  gcaaggcca  60
atcatcaac  ccagcgagg  cccccacct  ccgaaggag  aggtgctga  gctctacaa  120
agcatgaca  tgcttaaca  catggaccg  atcctctat  agtctcagc  gcagggccg  180
atctccttc  acatgacca  ctatggtga  gagggcacg  acgtgggga  tgccgccgc  240
ctggacaac  cggacctgg  gtttggcca  taccgggag  caggtgtgc  gatgtatcg  300
gactacccc  tggaactat  catggccca  tgctatggc  acatcagtg  cttgggcaa  360
gggcgccag  tgcctgtcc  ctacggctg  aaggaacgc  acttcgtca  tatctcctc  420
ccactggcc  cgcagatcc  tcaggcggt  ggggcggcg  acgcagcca  gcgggccaa  480
gccaacagg  tcgtcatct  ttacttcgg  gagggggca  ccagtgagg  ggacgccca  540
gacggcttc  acttcgctg  cacacttga  tgccccatc  tcttcttct  ccggaacaa  600
ggctacgcc  tctccacgc  cacctctga  cagtatcgc  gcgatggca  tgcagcacg  660
ggccccggg  atggcatca  gtcaatccg  gtggatggt  atgatgtgt  tgccgtata  720
aacgccact  aagaggccc  acggcgggc  gtggcagag  accagccct  tctcatcga  780
gccatgacc  acaggatcg  gcaccacag  accagtgac  acagttcag  gtaccgctc  840
gtggatgag  tcaattact  ggataaaca  gaccacccc  tctcccggc  gcggcacta  900
ctgctgagc  aaggctggt  ggatgagga  caggagaag  cctggagga  gcagtcccg  960
aggaaggtg  tggaggcct  tgagcaggc  gagcggaag  ccaaaccca  ccccaacct  1020
ctcttctca  acgtgtatc  ggagatgcc  gcccagctc  gcaagcagc  ggagtctct  1080
gcccgccac  tgcagacct  cggggagca  tacccactg  atcacttcg  taagtgaga  1140
ctgctcagc  cacccccac  catcctcag  taccccgag  ggtagcccc  ctctaaggg  1200
agcaggggg  cctgacagc  caccactgt  ttccccagt  agctccctc  aaaatactc  1260
gcggccagg  cggctgcca  tcttcaccc  tgctcctcc  ggctgttac  ttgtcaggg  1320
acagcatct  cagcagttg  tgaggctcc  tcagccccc  cttcacctg  tgttacagt  1380
ccttctccc  ggggctggg  gagggcaca  tcaggacta  aagcccctc  gggcatggg  1440
tggacatgg  aggtcagcc  gtggaactt  cgcaggtgc  agtggccag  agaggtcac  1500
aataaactg  atctctgcg  ctggctctct  1530



<210> 2434
<211> 445
<212> PRT
<213> Homo sapiens
<308> P12694
<400> 2434

Met Ala Val Ala Ile Ala Ala Ala Arg Val Trp Arg Leu Asn Arg Gly 
  1               5                  10                  15
Leu Ser Gln Ala Ala Leu Leu Leu Leu Arg Gln Pro Gly Ala Arg Gly 
             20                  25                  30
Leu Ala Arg Ser His Pro Pro Arg Gln Gln Gln Gln Phe Ser Ser Leu 
         35                  40                  45
Asp Asp Lys Pro Gln Phe Pro Gly Ala Ser Ala Glu Phe Ile Asp Lys 
     50                  55                  60
Leu Glu Phe Ile Gln Pro Asn Val Ile Ser Gly Ile Pro Ile Tyr Arg 
 65                  70                  75                  80
Val Met Asp Arg Gln Gly Gln Ile Ile Asn Pro Ser Glu Asp Pro His 
                 85                  90                  95
Leu Pro Lys Glu Lys Val Leu Lys Leu Tyr Lys Ser Met Thr Leu Leu 
             100                105                110
Asn Thr Met Asp Arg Ile Leu Tyr Glu Ser Gln Arg Gln Gly Arg Ile 
         115                120                125
Ser Phe Tyr Met Thr Asn Tyr Gly Glu Glu Gly Thr His Val Gly Ser 
     130                135                140
Ala Ala Ala Leu Asp Asn Thr Asp Leu Val Phe Gly Gln Tyr Arg Glu 
 145                150                155                160
Ala Gly Val Leu Met Tyr Arg Asp Tyr Pro Leu Glu Leu Phe Met Ala 
                 165                170                175
Gln Cys Tyr Gly Asn Ile Ser Asp Leu Gly Lys Gly Arg Gln Met Pro 
             180                185                190
Val His Tyr Gly Cys Lys Glu Arg His Phe Val Thr Ile Ser Ser Pro 
         195                200                205
Leu Ala Thr Gln Ile Pro Gln Ala Val Gly Ala Ala Tyr Ala Ala Lys 
     210                215                220
Arg Ala Asn Ala Asn Arg Val Val Ile Cys Tyr Phe Gly Glu Gly Ala 
 225                230                235                240
Ala Ser Glu Gly Asp Ala His Ala Gly Phe Asn Phe Ala Ala Thr Leu 
                 245                250                255
Glu Cys Pro Ile Ile Phe Phe Cys Arg Asn Asn Gly Tyr Ala Ile Ser 
             260                265                270
Thr Pro Thr Ser Glu Gln Tyr Arg Gly Asp Gly Ile Ala Ala Arg Gly 
         275                280                285
Pro Gly Tyr Gly Ile Met Ser Ile Arg Val Asp Gly Asn Asp Val Phe 
     290                295                300
Ala Val Tyr Asn Ala Thr Lys Glu Ala Arg Arg Arg Ala Val Ala Glu 
 305                310                315                320
Asn Gln Pro Phe Leu Ile Glu Ala Met Thr Tyr Arg Ile Gly His His 
                 325                330                335
Ser Thr Ser Asp Asp Ser Ser Ala Tyr Arg Ser Val Asp Glu Val Asn 
             340                345                350
Tyr Trp Asp Lys Gln Asp His Pro Ile Ser Arg Leu Arg His Tyr Leu 
         355                360                365
Leu Ser Gln Gly Trp Trp Asp Glu Glu Gln Glu Lys Ala Trp Arg Lys 
     370                375                380
Gln Ser Arg Arg Lys Val Met Glu Ala Phe Glu Gln Ala Glu Arg Lys 
 385                390                395                400
Pro Lys Pro Asn Pro Asn Leu Leu Phe Ser Asp Val Tyr Gln Glu Met 
                 405                410                415
Pro Ala Gln Leu Arg Lys Gln Gln Glu Ser Leu Ala Arg His Leu Gln 
             420                425                430
Thr Tyr Gly Glu His Tyr Pro Leu Asp His Phe Asp Lys 
         435                440                445



<210> 2435
<211> 2144
<212> DNA
<213> Rattus norvegicus
<308> J02844
<400> 2435

gggagtcgt  gttcccatg  tacataatg  atacggctt  ttctaccac  tcagagatg  60
caggtttgt  gtgacatgt  catcctgga  gtcatgtct  gagactgat  cagaaaagt  120
agtggagat  atttttcat  ctttccacg  tatgataca  ctgatgaac  cggctcatc  180
ttagagact  agagacata  aggtcacag  aactgggta  agagaatgg  atggtgata  240
gacatggaa  gaatgttga  ttaaaggaa  cctgttaat  cagggatta  agagggatg  300
actctagat  tattctacc  taaagcctt  tgttgcaac  gcaatgcaa  ctcagacat  360
gtgaataga  ctatgcaat  tcttaagcc  caacaatgc  catctgtat  ttttaacaa  420
acaaatcct  ctctaatgt  aaaatattt  tgttggcac  tgtgtaggt  gcaagtcct  480
tgtgactat  ccatggaaa  tcaattggc  aagtcaatt  aagaacgaa  attccagta  540
caggactct  ttccgccct  gcccgttcc  tcgcttgaa  aatcactga  gaagtacct  600
gagtcagtg  agccatttg  aaatgaaga  gaatacaag  aaactgaag  aatagttca  660
aagtttcaa  atggagttg  caagacatt  catcagaag  tacttgaaa  ggctaaagg  720
aaaagaaac  ggctggaag  gtggtggct  aatgtcgcc  acttggatg  gcgtattcc  780
tcacaactg  acgtgaact  tgtgggtcc  tctccccac  ttgaacact  ctggcctgc  840
agggaaggc  ctcagttgg  aagaggaag  atactactg  ggcacaact  gaactactg  900
cagctgcta  gaagagaaa  attgcctgt  cataaatct  gaaatactc  tctagacat  960
aaccaattc  ggatgctgt  ttctacctg  aaggttccg  gaatcacta  agattcgat  1020
atgaattat  ttaagactg  gagcgaggg  cattgtccg  cccacattg  cgtgctgtg  1080
cgaggcaga  cgtttgtct  cgatgtcct  catgacggt  gtttgatca  cccaccaga  1140
cttctcaga  aactgacat  catctacca  aaatgctgg  atgaacctg  tgggcccag  1200
atagcggca  taaccagtg  ggagcgaac  cggtgggcg  aggcaagag  atatctgat  1260
ggtcttgat  cagagaact  gactttatt  gaaaaaatt  aatccagtt  atttgtgta  1320
tccatagaa  acaccagtc  acatgcaac  ccagaaaat  tttctcagg  ctttgaaat  1380
cttcttggt  gagatccag  agtgcgctg  ggtgacaag  cctataatc  gatttcctt  1440
gctaacgga  tatttggct  tagctgtga  catgctcct  atgatgcaa  gtttatggt  1500
aacattgct  actatgttg  tgagaagct  ctagagacg  aagggagat  gaagggttc  1560
gaaaaagtc  gggatatac  gttgccaga  gagctggct  tcactgtgg  tgagaagat  1620
ctgaatgac  tctaccaag  caaagccca  cacctcaaa  cagcatctg  tttacagat  1680
gcagcatct  ccttcacat  ttttggcaa  aagctcact  agaaggagg  ccttcaccc  1740
gacaccttt  ttcagctcg  tcttcagct  gcctactac  gacttcatg  acgccccgg  1800
tgctgctat  aaacagcta  gacaagata  ttttaccat  gccgaacag  gactgtgcg  1860
tcttgtaca  tggaggccg  cagtggtgc  agtccatgc  ggatccttc  gccagtctc  1920
ttgaacgtc  gcaaaagat  ttagacgct  ttgcaaagc  taacaagat  atgagagat  1980
gttcccatg  aaaaggatt  gaccgtcac  ttttaggcc  tttgctcat  gcaaaagag  2040
aaggcctcc  tgttccaga  ctgtttgag  atccacttt  ctccagaag  ggaggaggt  2100
ggaattttg  gctgtcaac  agtctggtt  gttttaata  ttac  2144



<210> 2436
<211> 612
<212> PRT
<213> Rattus norvegicus
<308> P11466
<400> 2436

Met Glu Asn Gln Leu Ala Lys Ser Ile Glu Glu Arg Thr Phe Gln Tyr 
  1               5                  10                  15
Gln Asp Ser Leu Pro Pro Leu Pro Val Pro Ser Leu Glu Glu Ser Leu 
             20                  25                  30
Lys Lys Tyr Leu Glu Ser Val Lys Pro Phe Ala Asn Glu Asp Glu Tyr 
         35                  40                  45
Lys Lys Thr Glu Glu Ile Val Gln Lys Phe Gln Asp Gly Val Gly Lys 
     50                  55                  60
Thr Leu His Gln Lys Leu Leu Glu Arg Ala Lys Gly Lys Arg Asn Trp 
 65                  70                  75                  80
Leu Glu Glu Trp Trp Leu Asn Val Ala Tyr Leu Asp Val Arg Ile Pro 
                 85                  90                  95
Ser Gln Leu Asn Val Asn Phe Val Gly Pro Ser Pro His Phe Glu His 
             100                105                110
Tyr Trp Pro Ala Arg Glu Gly Thr Gln Leu Glu Arg Gly Ser Ile Leu 
         115                120                125
Leu Trp His Asn Leu Asn Tyr Trp Gln Leu Leu Arg Arg Glu Lys Leu 
     130                135                140
Pro Val His Lys Ser Gly Asn Thr Pro Leu Asp Met Asn Gln Phe Arg 
 145                150                155                160
Met Leu Phe Ser Thr Cys Lys Val Pro Gly Ile Thr Arg Asp Ser Ile 
                 165                170                175
Met Asn Tyr Phe Lys Thr Glu Ser Glu Gly His Cys Pro Thr His Ile 
             180                185                190
Ala Val Leu Cys Arg Gly Arg Ala Phe Val Phe Asp Val Leu His Asp 
         195                200                205
Gly Cys Leu Ile Thr Pro Pro Glu Leu Leu Arg Gln Leu Thr Tyr Ile 
     210                215                220
Tyr Gln Lys Cys Trp Asn Glu Pro Val Gly Pro Ser Ile Ala Ala Leu 
 225                230                235                240
Thr Ser Glu Glu Arg Thr Arg Trp Ala Lys Ala Arg Glu Tyr Leu Ile 
                 245                250                255
Gly Leu Asp Pro Glu Asn Leu Thr Leu Leu Glu Lys Ile Gln Ser Ser 
             260                265                270
Leu Phe Val Tyr Ser Ile Glu Asp Thr Ser Pro His Ala Thr Pro Glu 
         275                280                285
Asn Phe Ser Gln Val Phe Glu Met Leu Leu Gly Gly Asp Pro Ala Val 
     290                295                300
Arg Trp Gly Asp Lys Ser Tyr Asn Leu Ile Ser Phe Ala Asn Gly Ile 
 305                310                315                320
Phe Gly Cys Ser Cys Asp His Ala Pro Tyr Asp Ala Met Leu Met Val 
                 325                330                335
Asn Ile Ala His Tyr Val Asp Glu Lys Leu Leu Glu Thr Glu Gly Arg 
             340                345                350
Trp Lys Gly Ser Glu Lys Val Arg Asp Ile Pro Leu Pro Glu Glu Leu 
         355                360                365
Ala Phe Thr Val Asp Glu Lys Ile Leu Asn Asp Val Tyr Gln Ala Lys 
     370                375                380
Ala Gln His Leu Lys Ala Ala Ser Asp Leu Gln Ile Ala Ala Ser Thr 
 385                390                395                400
Phe Thr Ser Phe Gly Lys Lys Leu Thr Lys Lys Glu Ala Leu His Pro 
                 405                410                415
Asp Thr Phe Ile Gln Leu Ala Leu Gln Leu Ala Tyr Tyr Arg Leu His 
             420                425                430
Gly Arg Pro Gly Cys Cys Tyr Glu Thr Ala Met Thr Arg Tyr Phe Tyr 
         435                440                445
His Gly Arg Thr Glu Thr Val Arg Ser Cys Thr Val Glu Ala Val Arg 
     450                455                460
Trp Cys Gln Ser Met Gln Asp Pro Ser Ala Ser Leu Leu Glu Arg Gln 
 465                470                475                480
Gln Lys Met Leu Asp Ala Phe Ala Lys His Asn Lys Met Met Arg Asp 
                 485                490                495
Cys Ser His Gly Lys Gly Phe Asp Arg His Leu Leu Gly Leu Leu Leu 
             500                505                510
Ile Ala Lys Glu Glu Gly Leu Pro Val Pro Glu Leu Phe Glu Asp Pro 
         515                520                525
Leu Phe Ser Arg Ser Gly Gly Gly Gly Asn Phe Val Leu Ser Thr Ser 
     530                535                540
Leu Val Gly Tyr Leu Arg Ile Gln Gly Val Val Val Pro Met Val His 
 545                550                555                560
Asn Gly Tyr Gly Phe Phe Tyr His Ile Arg Asp Asp Arg Phe Val Val 
                 565                570                575
Thr Cys Ser Ser Trp Arg Ser Cys Leu Glu Thr Asp Ala Glu Lys Leu 
             580                585                590
Val Glu Met Ile Phe His Ala Phe His Asp Met Ile His Leu Met Asn 
         595                600                605
Thr Ala His Leu 
     610



<210> 2437
<211> 2074
<212> DNA
<213> Homo sapiens
<308> AF168793
<400> 2437

ggcgcgggc  gtgaggacg  acagtcacc  acttagtcc  gttccctgt  atctcaaaa  60
aattgttgc  gcaggctcc  ggcagtctc  agcagttca  cttcttggt  tactggttt  120
ctattgtga  tttatcatg  aaaatcaat  ggctaaatc  actgaagaa  gaacatttc  180
gtaccagga  tctcttcca  cactgcctg  tccttcact  gaagaatca  taaaaaaat  240
ccttgaatc  gtgaaacca  ttgcaaatc  agaagaata  aagaaaact  aagaaatag  300
tcaaaaatt  caaagtggg  ttggagaaa  attgcacca  aaattgctt  aaagagcaa  360
aggaaaaag  aattggctg  aagagtggt  gctgaatgt  gcctatctg  atgttcgta  420
accatcaca  ttgaatgtc  actttgcgg  tcctgcagc  cattttgaa  actactggc  480
tccaaagga  gggactcaa  tagaaagag  aagtataac  ctttggcat  acttgaact  540
ctggcagct  ttaagaaaa  aaaagttgc  tgttcataa  gttggaaat  ctcctctag  600
tatgaatca  ttccgaatg  tattttcta  ctgcaaggt  ccaggaatt  ctagagact  660
cattatgaa  tattttagg  ctgagagtg  agggcgttc  ccaaaccac  ttgtagtgc  720
gtgtcgagg  cgagctttt  tctttgatg  aatacatga  ggatgtttg  tcaccccgc  780
agagcttct  agacaactg  catatatcc  caagaagtg  catagtgaa  ctgatggac  840
tgggattgc  gcattaact  gtgaggagc  aactcgatg  gctaaggca  gagaatatc  900
gattggtct  gatccagag  acttggctt  gttagaaaa  attcagagt  gtttactgg  960
atattccat  gaggatagc  gtccacatg  aacaccaga  gattattct  agattattg  1020
agccatcct  attggagat  caacagtac  ctggggtga  aaatcctat  acttgattt  1080
cttttctaa  ggagtattt  gctgtaatt  tgatcatgc  ccttttgat  caatgatta  1140
ggtgaacat  agttattat  tggatgaga  aatttttca  aatgaagga  gatggaagg  1200
ttcagagaa  gtacgagat  taccacttc  agaagagct  attttcatt  tggatgaga  1260
agttttaaa  gacatcaac  aagctaaag  ccagtatct  agggaggca  ctgatctac  1320
gattgcggc  tatgccttt  catcttttg  caaaaagct  accaagaac  agatgcttc  1380
cccggatac  tttattcag  ttgcacttc  gctggccta  tacagactt  atggacacc  1440
tggttgttg  tatgaaaca  ctatgacaa  acattttta  catggccgt  cagagacta  1500
gcgatcatg  acagttgaa  cagtgaggt  gtgccagtc  atgcaggat  cttctgtca  1560
tcttcgtga  cggcagcaa  agatgttac  agcttttgc  aagcataat  aaatgatga  1620
agattgttc  gctggaaaa  gatttgatc  tcacctttt  ggtctctta  tcatagcaa  1680
agaggaagg  cttcctgtt  cagaactct  tacggaccc  cttttttcc  aaagcggag  1740
aggtggaaa  tttgttctc  caacaagtc  ggttggcta  ttacgagtc  agggagtgg  1800
agttcccat  gtacacaat  gttatggat  tttctacca  atcagagat  acaggtttg  1860
tgtggcctg  tcagcctgg  aatcctgtc  cgagactga  gcggaaaag  tagttcagc  1920
gactttttg  gcttttcat  atatgatac  gctgatgaa  tctactcat  tttagagat  1980
aatcatcta  taagcactt  ccaaaacat  tcattaaac  gagtgctgg  agtgagttg  2040
taatatgag  tgggaagga  tgttgactt  ctaa  2074



<210> 2438
<211> 612
<212> PRT
<213> Homo sapiens
<308> Q9UKG9
<400> 2438

Met Glu Asn Gln Leu Ala Lys Ser Thr Glu Glu Arg Thr Phe Gln Tyr 
  1               5                  10                  15
Gln Asp Ser Leu Pro Ser Leu Pro Val Pro Ser Leu Glu Glu Ser Leu 
             20                  25                  30
Lys Lys Tyr Leu Glu Ser Val Lys Pro Phe Ala Asn Gln Glu Glu Tyr 
         35                  40                  45
Lys Lys Thr Glu Glu Ile Val Gln Lys Phe Gln Ser Gly Ile Gly Glu 
     50                  55                  60
Lys Leu His Gln Lys Leu Leu Glu Arg Ala Lys Gly Lys Arg Asn Trp 
 65                  70                  75                  80
Leu Glu Glu Trp Trp Leu Asn Val Ala Tyr Leu Asp Val Arg Ile Pro 
                 85                  90                  95
Ser Gln Leu Asn Val Asn Phe Ala Gly Pro Ala Ala His Phe Glu His 
             100                105                110
Tyr Trp Pro Pro Lys Glu Gly Thr Gln Leu Glu Arg Gly Ser Ile Thr 
         115                120                125
Leu Trp His Asn Leu Asn Tyr Trp Gln Leu Leu Arg Lys Glu Lys Leu 
     130                135                140
Pro Val His Lys Val Gly Asn Thr Pro Leu Asp Met Asn Gln Phe Arg 
 145                150                155                160
Met Leu Phe Ser Thr Cys Lys Val Pro Gly Ile Thr Arg Asp Ser Ile 
                 165                170                175
Met Asn Tyr Phe Arg Thr Glu Ser Glu Gly Arg Ser Pro Asn His Ile 
             180                185                190
Val Val Leu Cys Arg Gly Arg Ala Phe Val Phe Asp Val Ile His Glu 
         195                200                205
Gly Cys Leu Val Thr Pro Pro Glu Leu Leu Arg Gln Leu Thr Tyr Ile 
     210                215                220
His Lys Lys Cys His Ser Glu Pro Asp Gly Pro Gly Ile Ala Ala Leu 
 225                230                235                240
Thr Ser Glu Glu Arg Thr Arg Trp Ala Lys Ala Arg Glu Tyr Leu Ile 
                 245                250                255
Gly Leu Asp Pro Glu Asn Leu Ala Leu Leu Glu Lys Ile Gln Ser Ser 
             260                265                270
Leu Leu Val Tyr Ser Met Glu Asp Ser Ser Pro His Val Thr Pro Glu 
         275                280                285
Asp Tyr Ser Glu Ile Ile Ala Ala Ile Leu Ile Gly Asp Pro Thr Val 
     290                295                300
Arg Trp Gly Asp Lys Ser Tyr Asn Leu Ile Ser Phe Ser Asn Gly Val 
 305                310                315                320
Phe Gly Cys Asn Cys Asp His Ala Pro Phe Asp Ala Met Ile Met Val 
                 325                330                335
Asn Ile Ser Tyr Tyr Val Asp Glu Lys Ile Phe Gln Asn Glu Gly Arg 
             340                345                350
Trp Lys Gly Ser Glu Lys Val Arg Asp Ile Pro Leu Pro Glu Glu Leu 
         355                360                365
Ile Phe Ile Val Asp Glu Lys Val Leu Asn Asp Ile Asn Gln Ala Lys 
     370                375                380
Ala Gln Tyr Leu Arg Glu Ala Ser Asp Leu Gln Ile Ala Ala Tyr Ala 
 385                390                395                400
Phe Thr Ser Phe Gly Lys Lys Leu Thr Lys Asn Lys Met Leu His Pro 
                 405                410                415
Asp Thr Phe Ile Gln Leu Ala Leu Gln Leu Ala Tyr Tyr Arg Leu His 
             420                425                430
Gly His Pro Gly Cys Cys Tyr Glu Thr Ala Met Thr Arg His Phe Tyr 
         435                440                445
His Gly Arg Thr Glu Thr Met Arg Ser Cys Thr Val Glu Ala Val Arg 
     450                455                460
Trp Cys Gln Ser Met Gln Asp Pro Ser Val Asn Leu Arg Glu Arg Gln 
 465                470                475                480
Gln Lys Met Leu Gln Ala Phe Ala Lys His Asn Lys Met Met Lys Asp 
                 485                490                495
Cys Ser Ala Gly Lys Gly Phe Asp Arg His Leu Leu Gly Leu Leu Leu 
             500                505                510
Ile Ala Lys Glu Glu Gly Leu Pro Val Pro Glu Leu Phe Thr Asp Pro 
         515                520                525
Leu Phe Ser Lys Ser Gly Gly Gly Gly Asn Phe Val Leu Ser Thr Ser 
     530                535                540
Leu Val Gly Tyr Leu Arg Val Gln Gly Val Val Val Pro Met Val His 
 545                550                555                560
Asn Gly Tyr Gly Phe Phe Tyr His Ile Arg Asp Asp Arg Phe Val Val 
                 565                570                575
Ala Cys Ser Ala Trp Lys Ser Cys Pro Glu Thr Asp Ala Glu Lys Leu 
             580                585                590
Val Gln Leu Thr Phe Cys Ala Phe His Asp Met Ile Gln Leu Met Asn 
         595                600                605
Ser Thr His Leu 
     610



<210> 2439
<211> 948
<212> DNA
<213> Rattus norvegicus
<308> J02962
<400> 2439

aacagctag  ggagcggca  gaggagcac  aaccaggaa  atggcagac  gcttctcac  60
taatgatgc  ttagctggc  ctggaaacc  aaaccctcg  ggatggcct  gtgcatggg  120
gaaccagcc  ggggcagga  gctacccag  ggcctccta  cctggggcc  acccaggac  180
ggctcctcc  gggggttat  ctggacagg  tcctcctag  gcctatccg  gcccaactg  240
ccctagtgc  tatcctggc  caactgccc  tggagctta  cctggccca  ctgcccccg  300
agccttccc  gggcaacct  ggggacctg  agcctaccc  agtgctcct  gggcctacc  360
cagtgctcc  ggggcctat  ctgctactg  cccctttgg  gccccgact  gaccactga  420
agtgcccta  gatatgccc  tgcctggag  agtcatgcc  cgcatgctg  tcacaatca  480
aggcacagt  aagcccaac  caaacagta  cactctgaa  ttcaagaaa  ggaacgaca  540
cgccttcca  tttaacccc  gcttcaatg  gaacaacag  agagtcatc  tgtgcaaca  600
gaagcagga  aataactgg  gaagggaag  aagacagtc  gctttcccc  ttgagagcg  660
caaaccatt  aaaatacag  tcctggttg  agccgacca  ttcaaggtt  cggtcaatg  720
tgttcatct  ttgcagtat  accatcgga  gaagaacct  agggaaatc  gccaactgg  780
gatcattgg  gacataacc  tcaccagcg  ttcccacgc  atgatctaa  ccagaaggg  840
tgggccggc  ccagaactg  cctgtgtgt  atgagcggg  aactttgca  ttctctctc  900
ttatacttc  tgtaagaca  ccatttaat  aagtctcgt  ctgagaga  948



<210> 2440
<211> 261
<212> PRT
<213> Rattus norvegicus
<308> P08699
<400> 2440

Ala Asp Gly Phe Ser Leu Asn Asp Ala Leu Ala Gly Ser Gly Asn Pro 
  1               5                  10                  15
Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Gly Ala Gly 
             20                  25                  30
Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln Ala Pro 
         35                  40                  45
Pro Gly Gly Tyr Pro Gly Gln Ala Pro Pro Ser Ala Tyr Pro Gly Pro 
     50                  55                  60
Thr Gly Pro Ser Ala Tyr Pro Gly Pro Thr Ala Pro Gly Ala Tyr Pro 
 65                  70                  75                  80
Gly Pro Thr Ala Pro Gly Ala Phe Pro Gly Gln Pro Gly Gly Pro Gly 
                 85                  90                  95
Ala Tyr Pro Ser Ala Pro Gly Ala Tyr Pro Ser Ala Pro Gly Ala Tyr 
             100                105                110
Pro Ala Thr Gly Pro Phe Gly Ala Pro Thr Gly Pro Leu Thr Val Pro 
         115                120                125
Tyr Asp Met Pro Leu Pro Gly Gly Val Met Pro Arg Met Leu Ile Thr 
     130                135                140
Ile Ile Gly Thr Val Lys Pro Asn Ala Asn Ser Ile Thr Leu Asn Phe 
 145                150                155                160
Lys Lys Gly Asn Asp Ile Ala Phe His Phe Asn Pro Arg Phe Asn Glu 
                 165                170                175
Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Gln Asp Asn Asn Trp 
             180                185                190
Gly Arg Glu Glu Arg Gln Ser Ala Phe Pro Phe Glu Ser Gly Lys Pro 
         195                200                205
Phe Lys Ile Gln Val Leu Val Glu Ala Asp His Phe Lys Val Ala Val 
     210                215                220
Asn Asp Val His Leu Leu Gln Tyr Asn His Arg Met Lys Asn Leu Arg 
 225                230                235                240
Glu Ile Ser Gln Leu Gly Ile Ile Gly Asp Ile Thr Leu Thr Ser Ala 
                 245                250                255
Ser His Ala Met Ile 
             260



<210> 2441
<211> 914
<212> DNA
<213> Homo sapiens
<308> M57710
<400> 2441

ccagccaac  agcggaaaa  ggcagacaa  ttttcgctc  atgatgcgt  atctgggtc  60
ggaaaccca  accctcaag  atggcctgg  gcatggggg  accagcctg  tggggcagg  120
ggctaccca  gggcttcct  tcctggggc  taccccggg  aggcacccc  aggggctta  180
cctggacag  cacctccag  cgcctacca  ggagcacct  gagcttatc  cggagcacc  240
gcacctgga  tctacccag  gccacccag  ggccctggg  cctacccat  ttctggaca  300
ccaagtgcc  ccggagcct  ccctgccac  ggcccctat  gcgcccctg  tgggccact  360
attgtgcct  ataacctgc  tttgcctgg  ggagtggtg  ctcgcatgc  gataacaat  420
ctgggcacg  tgaagccca  tgcaaacag  attgcttta  atttccaaa  agggaatga  480
gttgccttc  actttaacc  acgcttcaa  gagaacaac  ggagagtca  tgtttgcaa  540
acaaagctg  ataataact  gggaaggga  gaaagacag  cggttttcc  atttgaaag  600
gggaaacca  tcaaaatac  agtactggt  gaacctgac  acttcaagg  tgcagtgaa  660
gatgctcac  tgttgcagt  caatcatcg  gttaaaaaa  tcaatgaaa  cagcaaact  720
ggaatttct  gtgacatag  cctcaccag  gcttcatat  ccatgatat  atctgaaag  780
ggcagatta  aaaaaaaaa  aaagaatct  aaccttaca  gtgtaaagg  ttcatgttc  840
ctgtgagtg  aaattttta  attcatcaa  atccctctt  taagtcatc  acttaataa  900
tattacagt  aaag  914



<210> 2442
<211> 249
<212> PRT
<213> Homo sapiens
<308> P17931
<400> 2442

Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn Pro 
  1               5                  10                  15
Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly Ala 
             20                  25                  30
Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln Ala 
         35                  40                  45
Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr His Gly 
     50                  55                  60
Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro Gly 
 65                  70                  75                  80
Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser Ala 
                 85                  90                  95
Pro Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly Pro 
             100                105                110
Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg 
         115                120                125
Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg Ile 
     130                135                140
Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro 
 145                150                155                160
Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Leu 
                 165                170                175
Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe Glu 
             180                185                190
Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His Phe 
         195                200                205
Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Val 
     210                215                220
Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp 
 225                230                235                240
Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                 245



<210> 2443
<211> 1671
<212> DNA
<213> Rattus norvegicus
<308> J03179
<400> 2443

cctttcttt  cgagaagtg  aaaattggc  agagccaga  tctcgccca  ctggtacag  60
aggagcgcg  gcctgtgtc  cttggggac  cacagttgc  aagagacag  tgcttgatt  120
ggtcaccca  tcgcccaga  tataggagc  tcccgggac  ctcttgagt  gcacctttc  180
gcagagcag  ctgtttgag  ccccgcagt  ctcgtagga  ttgaagcgt  ctgatactg  240
aggcttgct  gccgcgctc  cccgactct  ggacacatt  gtccgagcc  caggagtgt  300
cgggtgact  acatatcat  tcttcgact  tccatgagc  catgaacct  ggagcaggt  360
cccggaaat  gcgcggcct  tgagcgaca  gaccccggg  cccctgctg  tgggtggcc  420
ggctggggc  ccccctggc  ggggagcgc  gcttgggct  aggagcctt  tgcagggaa  480
cagcaagcc  aaagaaccg  ccagctgtc  cctgaagga  aaggagcgc  aggcaactc  540
gccctcagc  cccgtcccg  gacccgtcc  ggaaacggc  ggcccagcg  atgccccaa  600
tggggcggt  agtggcggt  ggtcccctc  ggggcgctc  gggcctgtg  ctggcccga  660
tctttttgc  ccgctgctg  gggaacgca  tttgccttt  ggggacgtg  aatacgtgg  720
cctggacgc  ttcttgctg  agcacgggc  accgccgag  ccgccgccc  ccgggggcc  780
gtcgccggc  ccctctcca  cgcgcactc  cgcgccctc  cccgggccc  gctcttgca  840
ctcctcttc  ccccgctcc  cgcccgggc  cgcccccgc  cgggccact  tgggagccg  900
cggcggcca  cgcgcaggc  tgacctcta  ggacacacc  agtcctgtg  acccagaca  960
cgtggaggt  ctaatgacc  ttgaacctg  tccggctga  cttgccctg  caagcattc  1020
aggccatga  acttttgac  ctcggaggc  ccgcttctc  gaggaggaa  tgaagcctc  1080
gccaatcat  aagaaggca  ggaaagtcc  ggtgcccga  gaacagaag  atgagaagt  1140
ctggagccg  aggtacaag  acaatgaag  agccaagag  tcgagagac  caagaagac  1200
caaggagaa  cagatatct  tgcgggcag  cttcctgga  aaggaaaac  ccctattgc  1260
gcaggaggt  gtggctgtg  ggcaggagc  gtcccacta  cgtgctgtg  tttcacgct  1320
ccaggccca  cacgggaca  tgtgaggcc  cttccaccc  gccagggca  agtcctgtt  1380
cttgttcag  cttacacct  acacccccc  tcctccttg  cccatggcc  atggtctgg  1440
cagctaggt  cccaggaac  tcatgatgc  gacaaatac  tttatattt  taagaaaaa  1500
ctagccttc  cccacctcc  ttgtggggg  ggggagggt  ctgtgtgca  ttttagcat  1560
tcgaggaac  catccatcc  accgcctcc  tcaacacaa  cctgaataa  tcttgagaa  1620
ccaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaagaat  c  1671



<210> 2444
<211> 325
<212> PRT
<213> Rattus norvegicus
<308> P16443
<400> 2444

Met Ala Arg Pro Leu Ser Asp Arg Thr Pro Gly Pro Leu Leu Leu Gly 
  1               5                  10                  15
Gly Pro Ala Gly Ala Pro Pro Gly Gly Gly Ala Leu Leu Gly Leu Arg 
             20                  25                  30
Ser Leu Leu Gln Gly Asn Ser Lys Pro Lys Glu Pro Ala Ser Cys Leu 
         35                  40                  45
Leu Lys Glu Lys Glu Arg Lys Ala Thr Leu Pro Ser Ala Pro Val Pro 
     50                  55                  60
Gly Pro Val Leu Glu Thr Ala Gly Pro Ala Asp Ala Pro Thr Gly Ala 
 65                  70                  75                  80
Val Ser Gly Gly Gly Ser Pro Arg Gly Arg Ser Gly Pro Val Ala Gly 
                 85                  90                  95
Pro Ser Leu Phe Ala Pro Leu Leu Trp Glu Arg Thr Leu Pro Phe Gly 
             100                105                110
Asp Val Glu Tyr Val Asp Leu Asp Ala Phe Leu Leu Glu His Gly Leu 
         115                120                125
Pro Pro Ser Pro Pro Pro Pro Gly Gly Leu Ser Pro Ala Pro Ser Pro 
     130                135                140
Ala Arg Thr Pro Ala Pro Ser Pro Gly Pro Gly Ser Cys Ser Ser Ser 
 145                150                155                160
Ser Pro Arg Ser Ser Pro Gly His Ala Pro Ala Arg Ala Thr Leu Gly 
                 165                170                175
Ala Ala Gly Gly His Arg Ala Gly Leu Thr Ser Arg Asp Thr Pro Ser 
             180                185                190
Pro Val Asp Pro Asp Thr Val Glu Val Leu Met Thr Phe Glu Pro Asp 
         195                200                205
Pro Ala Asp Leu Ala Leu Ser Ser Ile Pro Gly His Glu Thr Phe Asp 
     210                215                220
Pro Arg Arg His Arg Phe Ser Glu Glu Glu Leu Lys Pro Gln Pro Ile 
 225                230                235                240
Met Lys Lys Ala Arg Lys Val Gln Val Pro Glu Glu Gln Lys Asp Glu 
                 245                250                255
Lys Tyr Trp Ser Arg Arg Tyr Lys Asn Asn Glu Ala Ala Lys Arg Ser 
             260                265                270
Arg Asp Ala Arg Arg Leu Lys Glu Asn Gln Ile Ser Val Arg Ala Ala 
         275                280                285
Phe Leu Glu Lys Glu Asn Ala Leu Leu Arg Gln Glu Val Val Ala Val 
     290                295                300
Arg Gln Glu Leu Ser His Tyr Arg Ala Val Leu Ser Arg Tyr Gln Ala 
 305                310                315                320
Gln His Gly Thr Leu 
                 325



<210> 2445
<211> 1391
<212> DNA
<213> Homo sapiens
<308> D28468
<400> 2445

ccccccccc  cggtggccc  tcgccggag  cgtcgcccg  gcggacgcc  gcaccctcc  60
cagggccgg  ttcgtgcgg  tcggcttcc  cccgctcct  tcctgggca  gcccccgcc  120
gggctgccc  cgggaccgc  agcggccac  gcgcaggcc  gacctctcg  gacacaccc  180
gccctgtgg  cccagacac  gtggaggtg  tgatgacct  tgaacccga  ccagctgat  240
ttgccctat  aagcattcc  ggccacgag  cctttgacc  tcgaagaca  cgcttctca  300
aagaggaac  taagcccca  ccaatcatg  agaaggcaa  aaaaatcca  gtgccggag  360
agcagaagg  tgagaaata  tggagccgg  ggtacaaga  caacgaggc  gccaagcgg  420
cccgtgacg  ccggcggct  aaggagaac  agatatcgg  gcgggcggc  ttcctggag  480
aggagaacg  cctgctgcg  caggaagtt  tggccgtgc  ccaggagct  tcccactac  540
gcgccgtgc  gtcccgata  caggcccag  acggggccc  gtgaggctg  cccacatcc  600
cacctggcg  agctctcct  cgccttgct  agacttacg  cctgttccc  tcctgccct  660
tggcccacg  gccggccag  tgggtgccc  agggacgtg  taatgcaga  aaatacatt  720
atattttta  gaaaaagcg  gcctccccc  tcccttgcg  gggcgggga  ggttctctg  780
gtgtgtccc  ggcacgtca  ggaccctat  ctcccaccg  ctccgttaa  acgatcctg  840
ataaatctt  agaacccca  agccagctg  tgtggaaga  gagggcagc  ccctggcat  900
ctggctgca  cccgtgggc  gctccgggc  gtcgtccat  gagggcagg  gctgctgga  960
gtgctggag  ctgagtcct  ccgcgggct  tcggatgga  gaagggcag  aggtctgag  1020
ggaatgaag  gactgcctt  attgcatag  ccttttcaa  tgcttttta  attggggac  1080
gaggacgcg  atgagacga  caggggata  gaatttccc  gcccccacc  gcggggaga  1140
gaacattag  gcaaatcct  gcgccggcc  cggggaacc  gcccctcct  ggctgattg  1200
ccagctaaa  ggaggcacc  gagtggatg  ggcgaggct  cgggccctg  ccggccgac  1260
cactgaggc  taccccagc  agtacattc  aggtcctgt  attgggcga  gcgtaaaat  1320
gactccgcc  tcagccatc  tggccgggt  ggagcaggt  gcaagcgtc  ggactgagc  1380
ctgccccgt  a  1391



<210> 2446
<211> 325
<212> PRT
<213> Homo sapiens
<308> Q10586
<400> 2446

Met Ala Arg Pro Val Ser Asp Arg Thr Pro Ala Pro Leu Leu Leu Gly 
  1               5                  10                  15
Gly Pro Ala Gly Thr Pro Pro Gly Gly Gly Ala Leu Leu Gly Leu Arg 
             20                  25                  30
Ser Leu Leu Gln Gly Thr Ser Lys Pro Lys Glu Pro Ala Ser Cys Leu 
         35                  40                  45
Leu Lys Glu Lys Glu Arg Lys Ala Ala Leu Pro Ala Ala Thr Thr Pro 
     50                  55                  60
Gly Pro Gly Leu Glu Thr Ala Gly Pro Ala Asp Ala Pro Ala Gly Ala 
 65                  70                  75                  80
Val Val Gly Gly Gly Ser Pro Arg Gly Arg Pro Gly Pro Val Pro Ala 
                 85                  90                  95
Pro Gly Leu Leu Ala Pro Leu Leu Trp Glu Arg Thr Leu Pro Phe Gly 
             100                105                110
Asp Val Glu Tyr Val Asp Leu Asp Ala Phe Leu Leu Glu His Gly Leu 
         115                120                125
Pro Pro Ser Pro Pro Pro Pro Gly Gly Pro Ser Pro Glu Pro Ser Pro 
     130                135                140
Ala Arg Thr Pro Ala Pro Ser Pro Gly Pro Gly Ser Cys Gly Ser Ala 
 145                150                155                160
Ser Pro Arg Ser Ser Pro Gly His Ala Pro Ala Arg Ala Ala Leu Gly 
                 165                170                175
Thr Ala Ser Gly His Arg Ala Gly Leu Thr Ser Arg Asp Thr Pro Ser 
             180                185                190
Pro Val Asp Pro Asp Thr Val Glu Val Leu Met Thr Phe Glu Pro Asp 
         195                200                205
Pro Ala Asp Leu Ala Leu Ser Ser Ile Pro Gly His Glu Thr Phe Asp 
     210                215                220
Pro Arg Arg His Arg Phe Ser Glu Glu Glu Leu Lys Pro Gln Pro Ile 
 225                230                235                240
Met Lys Lys Ala Arg Lys Ile Gln Val Pro Glu Glu Gln Lys Asp Glu 
                 245                250                255
Lys Tyr Trp Ser Arg Arg Tyr Lys Asn Asn Glu Ala Ala Lys Arg Ser 
             260                265                270
Arg Asp Ala Arg Arg Leu Lys Glu Asn Gln Ile Ser Val Arg Ala Ala 
         275                280                285
Phe Leu Glu Lys Glu Asn Ala Leu Leu Arg Gln Glu Val Val Ala Val 
     290                295                300
Arg Gln Glu Leu Ser His Tyr Arg Ala Val Leu Ser Arg Tyr Gln Ala 
 305                310                315                320
Gln His Gly Ala Leu 
                 325



<210> 2447
<211> 1671
<212> DNA
<213> Rattus norvegicus
<308> J03179
<400> 2447

cctttcttt  cgagaagtg  aaaattggc  agagccaga  tctcgccca  ctggtacag  60
aggagcgcg  gcctgtgtc  cttggggac  cacagttgc  aagagacag  tgcttgatt  120
ggtcaccca  tcgcccaga  tataggagc  tcccgggac  ctcttgagt  gcacctttc  180
gcagagcag  ctgtttgag  ccccgcagt  ctcgtagga  ttgaagcgt  ctgatactg  240
aggcttgct  gccgcgctc  cccgactct  ggacacatt  gtccgagcc  caggagtgt  300
cgggtgact  acatatcat  tcttcgact  tccatgagc  catgaacct  ggagcaggt  360
cccggaaat  gcgcggcct  tgagcgaca  gaccccggg  cccctgctg  tgggtggcc  420
ggctggggc  ccccctggc  ggggagcgc  gcttgggct  aggagcctt  tgcagggaa  480
cagcaagcc  aaagaaccg  ccagctgtc  cctgaagga  aaggagcgc  aggcaactc  540
gccctcagc  cccgtcccg  gacccgtcc  ggaaacggc  ggcccagcg  atgccccaa  600
tggggcggt  agtggcggt  ggtcccctc  ggggcgctc  gggcctgtg  ctggcccga  660
tctttttgc  ccgctgctg  gggaacgca  tttgccttt  ggggacgtg  aatacgtgg  720
cctggacgc  ttcttgctg  agcacgggc  accgccgag  ccgccgccc  ccgggggcc  780
gtcgccggc  ccctctcca  cgcgcactc  cgcgccctc  cccgggccc  gctcttgca  840
ctcctcttc  ccccgctcc  cgcccgggc  cgcccccgc  cgggccact  tgggagccg  900
cggcggcca  cgcgcaggc  tgacctcta  ggacacacc  agtcctgtg  acccagaca  960
cgtggaggt  ctaatgacc  ttgaacctg  tccggctga  cttgccctg  caagcattc  1020
aggccatga  acttttgac  ctcggaggc  ccgcttctc  gaggaggaa  tgaagcctc  1080
gccaatcat  aagaaggca  ggaaagtcc  ggtgcccga  gaacagaag  atgagaagt  1140
ctggagccg  aggtacaag  acaatgaag  agccaagag  tcgagagac  caagaagac  1200
caaggagaa  cagatatct  tgcgggcag  cttcctgga  aaggaaaac  ccctattgc  1260
gcaggaggt  gtggctgtg  ggcaggagc  gtcccacta  cgtgctgtg  tttcacgct  1320
ccaggccca  cacgggaca  tgtgaggcc  cttccaccc  gccagggca  agtcctgtt  1380
cttgttcag  cttacacct  acacccccc  tcctccttg  cccatggcc  atggtctgg  1440
cagctaggt  cccaggaac  tcatgatgc  gacaaatac  tttatattt  taagaaaaa  1500
ctagccttc  cccacctcc  ttgtggggg  ggggagggt  ctgtgtgca  ttttagcat  1560
tcgaggaac  catccatcc  accgcctcc  tcaacacaa  cctgaataa  tcttgagaa  1620
ccaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaagaat  c  1671



<210> 2448
<211> 325
<212> PRT
<213> Rattus norvegicus
<308> P16443
<400> 2448

Met Ala Arg Pro Leu Ser Asp Arg Thr Pro Gly Pro Leu Leu Leu Gly 
  1               5                  10                  15
Gly Pro Ala Gly Ala Pro Pro Gly Gly Gly Ala Leu Leu Gly Leu Arg 
             20                  25                  30
Ser Leu Leu Gln Gly Asn Ser Lys Pro Lys Glu Pro Ala Ser Cys Leu 
         35                  40                  45
Leu Lys Glu Lys Glu Arg Lys Ala Thr Leu Pro Ser Ala Pro Val Pro 
     50                  55                  60
Gly Pro Val Leu Glu Thr Ala Gly Pro Ala Asp Ala Pro Thr Gly Ala 
 65                  70                  75                  80
Val Ser Gly Gly Gly Ser Pro Arg Gly Arg Ser Gly Pro Val Ala Gly 
                 85                  90                  95
Pro Ser Leu Phe Ala Pro Leu Leu Trp Glu Arg Thr Leu Pro Phe Gly 
             100                105                110
Asp Val Glu Tyr Val Asp Leu Asp Ala Phe Leu Leu Glu His Gly Leu 
         115                120                125
Pro Pro Ser Pro Pro Pro Pro Gly Gly Leu Ser Pro Ala Pro Ser Pro 
     130                135                140
Ala Arg Thr Pro Ala Pro Ser Pro Gly Pro Gly Ser Cys Ser Ser Ser 
 145                150                155                160
Ser Pro Arg Ser Ser Pro Gly His Ala Pro Ala Arg Ala Thr Leu Gly 
                 165                170                175
Ala Ala Gly Gly His Arg Ala Gly Leu Thr Ser Arg Asp Thr Pro Ser 
             180                185                190
Pro Val Asp Pro Asp Thr Val Glu Val Leu Met Thr Phe Glu Pro Asp 
         195                200                205
Pro Ala Asp Leu Ala Leu Ser Ser Ile Pro Gly His Glu Thr Phe Asp 
     210                215                220
Pro Arg Arg His Arg Phe Ser Glu Glu Glu Leu Lys Pro Gln Pro Ile 
 225                230                235                240
Met Lys Lys Ala Arg Lys Val Gln Val Pro Glu Glu Gln Lys Asp Glu 
                 245                250                255
Lys Tyr Trp Ser Arg Arg Tyr Lys Asn Asn Glu Ala Ala Lys Arg Ser 
             260                265                270
Arg Asp Ala Arg Arg Leu Lys Glu Asn Gln Ile Ser Val Arg Ala Ala 
         275                280                285
Phe Leu Glu Lys Glu Asn Ala Leu Leu Arg Gln Glu Val Val Ala Val 
     290                295                300
Arg Gln Glu Leu Ser His Tyr Arg Ala Val Leu Ser Arg Tyr Gln Ala 
 305                310                315                320
Gln His Gly Thr Leu 
                 325



<210> 2449
<211> 1391
<212> DNA
<213> Homo sapiens
<308> D28468
<400> 2449

ccccccccc  cggtggccc  tcgccggag  cgtcgcccg  gcggacgcc  gcaccctcc  60
cagggccgg  ttcgtgcgg  tcggcttcc  cccgctcct  tcctgggca  gcccccgcc  120
gggctgccc  cgggaccgc  agcggccac  gcgcaggcc  gacctctcg  gacacaccc  180
gccctgtgg  cccagacac  gtggaggtg  tgatgacct  tgaacccga  ccagctgat  240
ttgccctat  aagcattcc  ggccacgag  cctttgacc  tcgaagaca  cgcttctca  300
aagaggaac  taagcccca  ccaatcatg  agaaggcaa  aaaaatcca  gtgccggag  360
agcagaagg  tgagaaata  tggagccgg  ggtacaaga  caacgaggc  gccaagcgg  420
cccgtgacg  ccggcggct  aaggagaac  agatatcgg  gcgggcggc  ttcctggag  480
aggagaacg  cctgctgcg  caggaagtt  tggccgtgc  ccaggagct  tcccactac  540
gcgccgtgc  gtcccgata  caggcccag  acggggccc  gtgaggctg  cccacatcc  600
cacctggcg  agctctcct  cgccttgct  agacttacg  cctgttccc  tcctgccct  660
tggcccacg  gccggccag  tgggtgccc  agggacgtg  taatgcaga  aaatacatt  720
atattttta  gaaaaagcg  gcctccccc  tcccttgcg  gggcgggga  ggttctctg  780
gtgtgtccc  ggcacgtca  ggaccctat  ctcccaccg  ctccgttaa  acgatcctg  840
ataaatctt  agaacccca  agccagctg  tgtggaaga  gagggcagc  ccctggcat  900
ctggctgca  cccgtgggc  gctccgggc  gtcgtccat  gagggcagg  gctgctgga  960
gtgctggag  ctgagtcct  ccgcgggct  tcggatgga  gaagggcag  aggtctgag  1020
ggaatgaag  gactgcctt  attgcatag  ccttttcaa  tgcttttta  attggggac  1080
gaggacgcg  atgagacga  caggggata  gaatttccc  gcccccacc  gcggggaga  1140
gaacattag  gcaaatcct  gcgccggcc  cggggaacc  gcccctcct  ggctgattg  1200
ccagctaaa  ggaggcacc  gagtggatg  ggcgaggct  cgggccctg  ccggccgac  1260
cactgaggc  taccccagc  agtacattc  aggtcctgt  attgggcga  gcgtaaaat  1320
gactccgcc  tcagccatc  tggccgggt  ggagcaggt  gcaagcgtc  ggactgagc  1380
ctgccccgt  a  1391



<210> 2450
<211> 325
<212> PRT
<213> Homo sapiens
<308> Q10586
<400> 2450

Met Ala Arg Pro Val Ser Asp Arg Thr Pro Ala Pro Leu Leu Leu Gly 
  1               5                  10                  15
Gly Pro Ala Gly Thr Pro Pro Gly Gly Gly Ala Leu Leu Gly Leu Arg 
             20                  25                  30
Ser Leu Leu Gln Gly Thr Ser Lys Pro Lys Glu Pro Ala Ser Cys Leu 
         35                  40                  45
Leu Lys Glu Lys Glu Arg Lys Ala Ala Leu Pro Ala Ala Thr Thr Pro 
     50                  55                  60
Gly Pro Gly Leu Glu Thr Ala Gly Pro Ala Asp Ala Pro Ala Gly Ala 
 65                  70                  75                  80
Val Val Gly Gly Gly Ser Pro Arg Gly Arg Pro Gly Pro Val Pro Ala 
                 85                  90                  95
Pro Gly Leu Leu Ala Pro Leu Leu Trp Glu Arg Thr Leu Pro Phe Gly 
             100                105                110
Asp Val Glu Tyr Val Asp Leu Asp Ala Phe Leu Leu Glu His Gly Leu 
         115                120                125
Pro Pro Ser Pro Pro Pro Pro Gly Gly Pro Ser Pro Glu Pro Ser Pro 
     130                135                140
Ala Arg Thr Pro Ala Pro Ser Pro Gly Pro Gly Ser Cys Gly Ser Ala 
 145                150                155                160
Ser Pro Arg Ser Ser Pro Gly His Ala Pro Ala Arg Ala Ala Leu Gly 
                 165                170                175
Thr Ala Ser Gly His Arg Ala Gly Leu Thr Ser Arg Asp Thr Pro Ser 
             180                185                190
Pro Val Asp Pro Asp Thr Val Glu Val Leu Met Thr Phe Glu Pro Asp 
         195                200                205
Pro Ala Asp Leu Ala Leu Ser Ser Ile Pro Gly His Glu Thr Phe Asp 
     210                215                220
Pro Arg Arg His Arg Phe Ser Glu Glu Glu Leu Lys Pro Gln Pro Ile 
 225                230                235                240
Met Lys Lys Ala Arg Lys Ile Gln Val Pro Glu Glu Gln Lys Asp Glu 
                 245                250                255
Lys Tyr Trp Ser Arg Arg Tyr Lys Asn Asn Glu Ala Ala Lys Arg Ser 
             260                265                270
Arg Asp Ala Arg Arg Leu Lys Glu Asn Gln Ile Ser Val Arg Ala Ala 
         275                280                285
Phe Leu Glu Lys Glu Asn Ala Leu Leu Arg Gln Glu Val Val Ala Val 
     290                295                300
Arg Gln Glu Leu Ser His Tyr Arg Ala Val Leu Ser Arg Tyr Gln Ala 
 305                310                315                320
Gln His Gly Ala Leu 
                 325



<210> 2451
<211> 2052
<212> DNA
<213> Rattus norvegicus
<308> J03190
<400> 2451

cgggacact  tgcagacat  gagactgtc  ttcgcagat  cccattctt  tcccgagtc  60
ctcaggcct  tctgcagaa  gcagggaaa  ctctgctgt  ctatgctca  aactgcccc  120
agatgatgg  agtcggggc  aagccggct  ctcggaccg  gtccacttc  gcagcacag  180
gccagcagg  caaagaaac  cctccagcc  atgagaaag  gaaaactgc  aaagccgca  240
tccagcagg  tcctgacga  tcccagatg  cacagactc  agacggcac  cagctcccg  300
ctggacacc  gtcaccctc  acaagccag  gctctggga  caagtgccc  ttcctggca  360
cacagctag  cagacgggc  gcagcgtct  ccgcaaggc  agtctggag  ttcaggagg  420
cgtggcagg  aatgcatgc  gtgaggaca  aggttgctc  aagcccagt  ctccccagc  480
tggtcaatg  aaaaaggga  ggagaaggt  caagcccac  gctgaagaa  ttccaggac  540
tcatgagaa  gcaaaggcc  gaaagagtg  ctcatcttc  tcaggataa  ttgcccaaa  600
tcgtttcca  ttttcaata  gatcatttc  ttgagaaga  aattgacga  aaaaaaaat  660
accacacct  ccgagtttt  aaaactgtg  accggagag  acagatctt  cccatggca  720
atgactaca  ggactccct  atcaccaat  atcaggtgt  ggtctggtc  agtaacgac  780
atctaggca  gagtcgaca  ccacgggtg  gtggggccg  catagagac  gtgaaacag  840
atggtgccg  tgcaggtgg  actagaaat  tttctggaa  gagcaagtt  catgtggaa  900
tggagcagg  gctggctga  ctccacggc  aggacgcgg  gctcttgtt  tcttcctgc  960
tcgtggcca  cgactccac  ctcttcacc  tggctaaga  gatgccagg  tgtgaaatt  1020
actctgatt  cgggaacca  gcctccatg  tccaaggga  tcgcaacag  cgagtgcca  1080
agtatatct  ccgccacaa  gatgtcaac  atctcagag  actgttgca  agatccgac  1140
cctcggtcc  caagatcgt  gcattcgaa  ctgtccatt  aatggatgg  gcagtgtgc  1200
ccctggaag  gctgtgtga  gtggcccat  agtttggag  gatcacgtt  gtggacgag  1260
tccatgcag  agggctcta  ggggcttca  gtggaggga  cggtgatcg  gatggagtc  1320
tgccaaaaa  ggacatcat  tctggaaca  tcggtaaag  gttcggctg  gttggagga  1380
acattgcca  cacgagttt  ctgatcgac  ccgtccggt  ctacgctgc  ggcttcatc  1440
tcaccacct  cctgccacc  atgctgctg  ctggagccc  ggagtctgt  cggatcctg  1500
agagcaatg  gggacgtgc  cttcgccgc  agcaccagc  caatgtcaa  cttatgagg  1560
agatgctaa  ggacgctgg  ctcccagtc  tccactgcc  cagccacat  atccctgtg  1620
gggttgccg  tgctgctaa  aacacagaa  tctgtgatg  gttgatgac  aggcataat  1680
tctacgtcc  ggccattaa  tacccaaca  tgcctcgtg  ggaggagct  ctccggatc  1740
cccccaccc  gcaccacac  ccgcagatg  tgaactact  cctagagaa  ctgctgctc  1800
cgtggaagc  agtcgggct  gaactgaag  cacattcgt  agctgaatg  aacttctgc  1860
ggaggccct  acacttcga  gtgatgagc  agagagaga  agcctattt  tcaggcatg  1920
gcaagatgg  gtctgccca  gcctgactg  gactcagtt  ttcacaaac  ccagaccat  1980
accataccc  aatagtagc  agaattgtc  ttagatgtg  agtaaatta  atattaaat  2040
ttaatctat  gt  2052



<210> 2452
<211> 642
<212> PRT
<213> Rattus norvegicus
<308> P13195
<400> 2452

Met Glu Thr Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln 
  1               5                  10                  15
Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn 
             20                  25                  30
Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Thr Val 
         35                  40                  45
Ser Thr Ser Ala Ala Gln Cys Gln Gln Val Lys Glu Thr Pro Pro Ala 
     50                  55                  60
Asn Glu Lys Glu Lys Thr Ala Lys Ala Ala Val Gln Gln Ala Pro Asp 
 65                  70                  75                  80
Glu Ser Gln Met Ala Gln Thr Pro Asp Gly Thr Gln Leu Pro Pro Gly 
                 85                  90                  95
His Pro Ser Pro Ser Thr Ser Gln Ser Ser Gly Ser Lys Cys Pro Phe 
             100                105                110
Leu Ala Ala Gln Leu Ala Arg Arg Ala Ala Ala Ser Ser Ala Arg Pro 
         115                120                125
Val Trp Ser Phe Arg Arg Thr Trp Gln Glu Met His Ala Val Arg Thr 
     130                135                140
Glu Val Ala Gln Ser Pro Val Leu Pro Ser Leu Val Asn Ala Lys Arg 
 145                150                155                160
Asp Gly Glu Gly Pro Ser Pro Leu Leu Lys Asn Phe Gln Asp Ile Met 
                 165                170                175
Arg Lys Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu 
             180                185                190
Pro Lys Val Val Ser Thr Phe Gln Tyr Asp His Phe Phe Glu Lys Lys 
         195                200                205
Ile Asp Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val 
     210                215                220
Asn Arg Arg Ala Gln Ile Phe Pro Met Ala Asp Asp Tyr Thr Asp Ser 
 225                230                235                240
Leu Ile Thr Asn Asn Gln Val Ser Val Trp Ser Ser Asn Asp Tyr Leu 
                 245                250                255
Gly Met Ser Arg His Pro Arg Val Cys Gly Ala Val Ile Glu Thr Val 
             260                265                270
Lys Gln His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr 
         275                280                285
Ser Lys Phe His Val Glu Leu Glu Gln Glu Leu Ala Asp Leu His Gly 
     290                295                300
Lys Asp Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser 
 305                310                315                320
Thr Leu Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser 
                 325                330                335
Asp Ser Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg 
             340                345                350
Val Pro Lys Tyr Ile Phe Arg His Asn Asp Val Asn His Leu Arg Glu 
         355                360                365
Leu Leu Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu 
     370                375                380
Thr Val His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys 
 385                390                395                400
Asp Val Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His 
                 405                410                415
Ala Val Gly Leu Tyr Gly Ala Ser Gly Gly Gly Ile Gly Asp Arg Asp 
             420                425                430
Gly Val Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala 
         435                440                445
Phe Gly Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Leu Leu Ile Asp 
     450                455                460
Thr Val Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro 
 465                470                475                480
Pro Met Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser 
                 485                490                495
Asn Glu Gly Arg Ala Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu 
             500                505                510
Met Arg Gln Met Leu Met Asp Ala Gly Leu Pro Val Ile His Cys Pro 
         515                520                525
Ser His Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu 
     530                535                540
Ile Cys Asp Glu Leu Met Thr Arg His Asn Ile Tyr Val Gln Ala Ile 
 545                550                555                560
Asn Tyr Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro 
                 565                570                575
Thr Pro His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Lys Leu 
             580                585                590
Leu Leu Thr Trp Lys Arg Val Gly Leu Glu Leu Lys Pro His Ser Ser 
         595                600                605
Ala Glu Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser 
     610                615                620
Glu Arg Glu Lys Ala Tyr Phe Ser Gly Met Ser Lys Met Val Ser Ala 
 625                630                635                640
Gln Ala 
                 645



<210> 2453
<211> 2146
<212> DNA
<213> Homo sapiens
<308> X56351
<400> 2453

agtgcccgc  tccttcgcc  ccgcctctg  agtcctcag  gcagtcttt  cacaggagc  60
agcatactt  ctgaacatg  agagtgttg  tcgccgctg  ccattctta  cccgagtcc  120
ccaggcctt  ctgcagaaa  caggcaaat  tctgttgtt  tatgcccaa  actgcccca  180
gatgatgga  gttggggcc  agccagccc  tcgggcatt  tccactgca  cagtacact  240
ccaacagat  aaagaaacc  ctccggcca  tgagaaaga  aaaactgct  aggccaagg  300
ccaacagac  cctgatgga  cccagcaga  tccagatgg  acacagctt  cgtctggac  360
ccccttgcc  gccacaagc  agggcactg  aagcaaatg  cctttcctg  cagcacaga  420
gaatcagag  ggcagcagt  tcttctgca  agccagtct  gagcttcag  aggatgtgc  480
ggaaatgaa  gccgtgagg  aagaggttg  tgaaacctc  gcaggcccc  gtgtggtta  540
tgtgaaaac  gatggaggg  atcccagtg  actgctgaa  aacttccag  acattatgc  600
aaagcaaag  ccagaaaga  tgtctcatc  tcttcaaga  aacttgcca  aatctgttt  660
cacttttca  tatgatcgt  tctttgaga  aaaaattga  gagaaaaag  atgaccaca  720
ctatcgagt  tttaaaact  tgaaccggc  agcacacat  ttccccatg  cagatgact  780
ttcagactc  ctcatcacc  aaaagcaag  gtcagtctg  tgcagtaat  actacctag  840
aatgagtcg  cacccacgg  tgtgtgggg  agttatgga  actttgaaa  aacatggtg  900
tggggcagg  ggtactaga  atatttctg  aactagtaa  ttccatgtg  acttagagc  960
ggagctggc  gacctccat  ggaaagatg  cgcactctt  ttttcctcg  gctttgtgg  1020
caatgactc  accctcttc  ccctggcta  gatgatgcc  ggctgtgag  tttactctg  1080
ttctgggaa  catgcctcc  tgatccaag  gattcgaaa  agccgagtg  caaagtaca  1140
cttccgcca  aatgatgtc  gccacctca  agaactgct  caaagatct  acccctcag  1200
ccccaagat  gtggcattt  aaactgtcc  ttcaatgga  ggggcggtg  gcccactgg  1260
agagctgtg  gatgtggcc  atgagtttg  agcaatcac  ttcgtggat  aggtccacg  1320
agtggggct  tatggggct  gaggcggag  gattgggga  cgggatgga  tcatgccaa  1380
aatggacat  atttctgga  cacttggca  agcctttgg  tgtgttgga  ggtacatcg  1440
cagcacgag  tctctgatt  acaccgtac  gtcctatgc  gctggcttc  tcttcacca  1500
ctctctgcc  cccatgctg  tggctggag  cctggagtc  gtgcggatc  tgaagagcg  1560
tgagggacg  gtgcttcgc  gccagcacc  gcgcaacgt  aaactcatg  gacagatgc  1620
aatggatgc  ggcctccct  ttgtccact  ccccagcca  atcatccct  tgcgggttg  1680
agatgctgc  aaaaacaca  aagtctgtg  tgaactaat  agcagacat  acatctacg  1740
gcaagcaat  aattaccct  cggtgcccc  gggagaaga  ctcctacgg  ttgccccca  1800
ccctcacca  acaccccag  tgatgaact  cttccttga  aatctgcta  tcacatgga  1860
gcaagtggg  ctggaactg  agcctcatt  ctcagctga  tgcaacttc  gcaggaggc  1920
actgcattt  gaagtgatg  gtgaaagag  gaagtccta  ttctcaggc  tgagcaagt  1980
ggtatctgc  caggcctga  catgacctc  attatttca  ttaacccca  gccattatc  2040
tatccagat  gtcttcaga  ttgtcttta  atgtgaatt  agttatatt  aattttaat  2100
tatagtaaa  acatagtcc  ggaaataaa  tcttgctta  atggtg  2146



<210> 2454
<211> 640
<212> PRT
<213> Homo sapiens
<308> P13196
<400> 2454

Met Glu Ser Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln 
  1               5                  10                  15
Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn 
             20                  25                  30
Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Ala Leu 
         35                  40                  45
Ser Thr Ala Ala Val His Tyr Gln Gln Ile Lys Glu Thr Pro Pro Ala 
     50                  55                  60
Ser Glu Lys Asp Lys Thr Ala Lys Ala Lys Val Gln Gln Thr Pro Asp 
 65                  70                  75                  80
Gly Ser Gln Gln Ser Pro Asp Gly Thr Gln Leu Pro Ser Gly His Pro 
                 85                  90                  95
Leu Pro Ala Thr Ser Gln Gly Thr Ala Ser Lys Cys Pro Phe Leu Ala 
             100                105                110
Ala Gln Met Asn Gln Arg Gly Ser Ser Val Phe Cys Lys Ala Ser Leu 
         115                120                125
Glu Leu Gln Glu Asp Val Gln Glu Met Asn Ala Val Arg Lys Glu Val 
     130                135                140
Ala Glu Thr Ser Ala Gly Pro Ser Val Val Ser Val Lys Thr Asp Gly 
 145                150                155                160
Gly Asp Pro Ser Gly Leu Leu Lys Asn Phe Gln Asp Ile Met Gln Lys 
                 165                170                175
Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu Pro Lys 
             180                185                190
Ser Val Ser Thr Phe Gln Tyr Asp Arg Phe Phe Glu Lys Lys Ile Asp 
         195                200                205
Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val Asn Arg 
     210                215                220
Arg Ala His Ile Phe Pro Met Ala Asp Asp Tyr Ser Asp Ser Leu Ile 
 225                230                235                240
Thr Lys Lys Gln Val Ser Val Trp Cys Ser Asn Asp Tyr Leu Gly Met 
                 245                250                255
Ser Arg His Pro Arg Val Cys Gly Ala Val Met Asp Thr Leu Lys Gln 
             260                265                270
His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys 
         275                280                285
Phe His Val Asp Leu Glu Arg Glu Leu Ala Asp Leu His Gly Lys Asp 
     290                295                300
Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser Thr Leu 
 305                310                315                320
Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser Asp Ser 
                 325                330                335
Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg Val Pro 
             340                345                350
Lys Tyr Ile Phe Arg His Asn Asp Val Ser His Leu Arg Glu Leu Leu 
         355                360                365
Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu Thr Val 
     370                375                380
His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys Asp Val 
 385                390                395                400
Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His Ala Val 
                 405                410                415
Gly Leu Tyr Gly Ala Arg Gly Gly Gly Ile Gly Asp Arg Asp Gly Val 
             420                425                430
Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly 
         435                440                445
Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Ser Leu Ile Asp Thr Val 
     450                455                460
Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro Pro Met 
 465                470                475                480
Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser Ala Glu 
                 485                490                495
Gly Arg Val Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu Met Arg 
             500                505                510
Gln Met Leu Met Asp Ala Gly Leu Pro Val Val His Cys Pro Ser His 
         515                520                525
Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu Val Cys 
     530                535                540
Asp Glu Leu Met Ser Arg His Asn Ile Tyr Val Gln Ala Ile Asn Tyr 
 545                550                555                560
Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro Thr Pro 
                 565                570                575
His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Asn Leu Leu Val 
             580                585                590
Thr Trp Lys Gln Val Gly Leu Glu Leu Lys Pro His Ser Ser Ala Glu 
         595                600                605
Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser Glu Arg 
     610                615                620
Glu Lys Ser Tyr Phe Ser Gly Leu Ser Lys Leu Val Ser Ala Gln Ala 
 625                630                635                640



<210> 2455
<211> 2052
<212> DNA
<213> Rattus norvegicus
<308> J03190
<400> 2455

cgggacact  tgcagacat  gagactgtc  ttcgcagat  cccattctt  tcccgagtc  60
ctcaggcct  tctgcagaa  gcagggaaa  ctctgctgt  ctatgctca  aactgcccc  120
agatgatgg  agtcggggc  aagccggct  ctcggaccg  gtccacttc  gcagcacag  180
gccagcagg  caaagaaac  cctccagcc  atgagaaag  gaaaactgc  aaagccgca  240
tccagcagg  tcctgacga  tcccagatg  cacagactc  agacggcac  cagctcccg  300
ctggacacc  gtcaccctc  acaagccag  gctctggga  caagtgccc  ttcctggca  360
cacagctag  cagacgggc  gcagcgtct  ccgcaaggc  agtctggag  ttcaggagg  420
cgtggcagg  aatgcatgc  gtgaggaca  aggttgctc  aagcccagt  ctccccagc  480
tggtcaatg  aaaaaggga  ggagaaggt  caagcccac  gctgaagaa  ttccaggac  540
tcatgagaa  gcaaaggcc  gaaagagtg  ctcatcttc  tcaggataa  ttgcccaaa  600
tcgtttcca  ttttcaata  gatcatttc  ttgagaaga  aattgacga  aaaaaaaat  660
accacacct  ccgagtttt  aaaactgtg  accggagag  acagatctt  cccatggca  720
atgactaca  ggactccct  atcaccaat  atcaggtgt  ggtctggtc  agtaacgac  780
atctaggca  gagtcgaca  ccacgggtg  gtggggccg  catagagac  gtgaaacag  840
atggtgccg  tgcaggtgg  actagaaat  tttctggaa  gagcaagtt  catgtggaa  900
tggagcagg  gctggctga  ctccacggc  aggacgcgg  gctcttgtt  tcttcctgc  960
tcgtggcca  cgactccac  ctcttcacc  tggctaaga  gatgccagg  tgtgaaatt  1020
actctgatt  cgggaacca  gcctccatg  tccaaggga  tcgcaacag  cgagtgcca  1080
agtatatct  ccgccacaa  gatgtcaac  atctcagag  actgttgca  agatccgac  1140
cctcggtcc  caagatcgt  gcattcgaa  ctgtccatt  aatggatgg  gcagtgtgc  1200
ccctggaag  gctgtgtga  gtggcccat  agtttggag  gatcacgtt  gtggacgag  1260
tccatgcag  agggctcta  ggggcttca  gtggaggga  cggtgatcg  gatggagtc  1320
tgccaaaaa  ggacatcat  tctggaaca  tcggtaaag  gttcggctg  gttggagga  1380
acattgcca  cacgagttt  ctgatcgac  ccgtccggt  ctacgctgc  ggcttcatc  1440
tcaccacct  cctgccacc  atgctgctg  ctggagccc  ggagtctgt  cggatcctg  1500
agagcaatg  gggacgtgc  cttcgccgc  agcaccagc  caatgtcaa  cttatgagg  1560
agatgctaa  ggacgctgg  ctcccagtc  tccactgcc  cagccacat  atccctgtg  1620
gggttgccg  tgctgctaa  aacacagaa  tctgtgatg  gttgatgac  aggcataat  1680
tctacgtcc  ggccattaa  tacccaaca  tgcctcgtg  ggaggagct  ctccggatc  1740
cccccaccc  gcaccacac  ccgcagatg  tgaactact  cctagagaa  ctgctgctc  1800
cgtggaagc  agtcgggct  gaactgaag  cacattcgt  agctgaatg  aacttctgc  1860
ggaggccct  acacttcga  gtgatgagc  agagagaga  agcctattt  tcaggcatg  1920
gcaagatgg  gtctgccca  gcctgactg  gactcagtt  ttcacaaac  ccagaccat  1980
accataccc  aatagtagc  agaattgtc  ttagatgtg  agtaaatta  atattaaat  2040
ttaatctat  gt  2052



<210> 2456
<211> 642
<212> PRT
<213> Rattus norvegicus
<308> P13195
<400> 2456

Met Glu Thr Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln 
  1               5                  10                  15
Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn 
             20                  25                  30
Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Thr Val 
         35                  40                  45
Ser Thr Ser Ala Ala Gln Cys Gln Gln Val Lys Glu Thr Pro Pro Ala 
     50                  55                  60
Asn Glu Lys Glu Lys Thr Ala Lys Ala Ala Val Gln Gln Ala Pro Asp 
 65                  70                  75                  80
Glu Ser Gln Met Ala Gln Thr Pro Asp Gly Thr Gln Leu Pro Pro Gly 
                 85                  90                  95
His Pro Ser Pro Ser Thr Ser Gln Ser Ser Gly Ser Lys Cys Pro Phe 
             100                105                110
Leu Ala Ala Gln Leu Ala Arg Arg Ala Ala Ala Ser Ser Ala Arg Pro 
         115                120                125
Val Trp Ser Phe Arg Arg Thr Trp Gln Glu Met His Ala Val Arg Thr 
     130                135                140
Glu Val Ala Gln Ser Pro Val Leu Pro Ser Leu Val Asn Ala Lys Arg 
 145                150                155                160
Asp Gly Glu Gly Pro Ser Pro Leu Leu Lys Asn Phe Gln Asp Ile Met 
                 165                170                175
Arg Lys Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu 
             180                185                190
Pro Lys Val Val Ser Thr Phe Gln Tyr Asp His Phe Phe Glu Lys Lys 
         195                200                205
Ile Asp Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val 
     210                215                220
Asn Arg Arg Ala Gln Ile Phe Pro Met Ala Asp Asp Tyr Thr Asp Ser 
 225                230                235                240
Leu Ile Thr Asn Asn Gln Val Ser Val Trp Ser Ser Asn Asp Tyr Leu 
                 245                250                255
Gly Met Ser Arg His Pro Arg Val Cys Gly Ala Val Ile Glu Thr Val 
             260                265                270
Lys Gln His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr 
         275                280                285
Ser Lys Phe His Val Glu Leu Glu Gln Glu Leu Ala Asp Leu His Gly 
     290                295                300
Lys Asp Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser 
 305                310                315                320
Thr Leu Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser 
                 325                330                335
Asp Ser Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg 
             340                345                350
Val Pro Lys Tyr Ile Phe Arg His Asn Asp Val Asn His Leu Arg Glu 
         355                360                365
Leu Leu Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu 
     370                375                380
Thr Val His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys 
 385                390                395                400
Asp Val Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His 
                 405                410                415
Ala Val Gly Leu Tyr Gly Ala Ser Gly Gly Gly Ile Gly Asp Arg Asp 
             420                425                430
Gly Val Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala 
         435                440                445
Phe Gly Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Leu Leu Ile Asp 
     450                455                460
Thr Val Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro 
 465                470                475                480
Pro Met Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser 
                 485                490                495
Asn Glu Gly Arg Ala Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu 
             500                505                510
Met Arg Gln Met Leu Met Asp Ala Gly Leu Pro Val Ile His Cys Pro 
         515                520                525
Ser His Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu 
     530                535                540
Ile Cys Asp Glu Leu Met Thr Arg His Asn Ile Tyr Val Gln Ala Ile 
 545                550                555                560
Asn Tyr Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro 
                 565                570                575
Thr Pro His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Lys Leu 
             580                585                590
Leu Leu Thr Trp Lys Arg Val Gly Leu Glu Leu Lys Pro His Ser Ser 
         595                600                605
Ala Glu Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser 
     610                615                620
Glu Arg Glu Lys Ala Tyr Phe Ser Gly Met Ser Lys Met Val Ser Ala 
 625                630                635                640
Gln Ala 
                 645



<210> 2457
<211> 2146
<212> DNA
<213> Homo sapiens
<308> X56351
<400> 2457

agtgcccgc  tccttcgcc  ccgcctctg  agtcctcag  gcagtcttt  cacaggagc  60
agcatactt  ctgaacatg  agagtgttg  tcgccgctg  ccattctta  cccgagtcc  120
ccaggcctt  ctgcagaaa  caggcaaat  tctgttgtt  tatgcccaa  actgcccca  180
gatgatgga  gttggggcc  agccagccc  tcgggcatt  tccactgca  cagtacact  240
ccaacagat  aaagaaacc  ctccggcca  tgagaaaga  aaaactgct  aggccaagg  300
ccaacagac  cctgatgga  cccagcaga  tccagatgg  acacagctt  cgtctggac  360
ccccttgcc  gccacaagc  agggcactg  aagcaaatg  cctttcctg  cagcacaga  420
gaatcagag  ggcagcagt  tcttctgca  agccagtct  gagcttcag  aggatgtgc  480
ggaaatgaa  gccgtgagg  aagaggttg  tgaaacctc  gcaggcccc  gtgtggtta  540
tgtgaaaac  gatggaggg  atcccagtg  actgctgaa  aacttccag  acattatgc  600
aaagcaaag  ccagaaaga  tgtctcatc  tcttcaaga  aacttgcca  aatctgttt  660
cacttttca  tatgatcgt  tctttgaga  aaaaattga  gagaaaaag  atgaccaca  720
ctatcgagt  tttaaaact  tgaaccggc  agcacacat  ttccccatg  cagatgact  780
ttcagactc  ctcatcacc  aaaagcaag  gtcagtctg  tgcagtaat  actacctag  840
aatgagtcg  cacccacgg  tgtgtgggg  agttatgga  actttgaaa  aacatggtg  900
tggggcagg  ggtactaga  atatttctg  aactagtaa  ttccatgtg  acttagagc  960
ggagctggc  gacctccat  ggaaagatg  cgcactctt  ttttcctcg  gctttgtgg  1020
caatgactc  accctcttc  ccctggcta  gatgatgcc  ggctgtgag  tttactctg  1080
ttctgggaa  catgcctcc  tgatccaag  gattcgaaa  agccgagtg  caaagtaca  1140
cttccgcca  aatgatgtc  gccacctca  agaactgct  caaagatct  acccctcag  1200
ccccaagat  gtggcattt  aaactgtcc  ttcaatgga  ggggcggtg  gcccactgg  1260
agagctgtg  gatgtggcc  atgagtttg  agcaatcac  ttcgtggat  aggtccacg  1320
agtggggct  tatggggct  gaggcggag  gattgggga  cgggatgga  tcatgccaa  1380
aatggacat  atttctgga  cacttggca  agcctttgg  tgtgttgga  ggtacatcg  1440
cagcacgag  tctctgatt  acaccgtac  gtcctatgc  gctggcttc  tcttcacca  1500
ctctctgcc  cccatgctg  tggctggag  cctggagtc  gtgcggatc  tgaagagcg  1560
tgagggacg  gtgcttcgc  gccagcacc  gcgcaacgt  aaactcatg  gacagatgc  1620
aatggatgc  ggcctccct  ttgtccact  ccccagcca  atcatccct  tgcgggttg  1680
agatgctgc  aaaaacaca  aagtctgtg  tgaactaat  agcagacat  acatctacg  1740
gcaagcaat  aattaccct  cggtgcccc  gggagaaga  ctcctacgg  ttgccccca  1800
ccctcacca  acaccccag  tgatgaact  cttccttga  aatctgcta  tcacatgga  1860
gcaagtggg  ctggaactg  agcctcatt  ctcagctga  tgcaacttc  gcaggaggc  1920
actgcattt  gaagtgatg  gtgaaagag  gaagtccta  ttctcaggc  tgagcaagt  1980
ggtatctgc  caggcctga  catgacctc  attatttca  ttaacccca  gccattatc  2040
tatccagat  gtcttcaga  ttgtcttta  atgtgaatt  agttatatt  aattttaat  2100
tatagtaaa  acatagtcc  ggaaataaa  tcttgctta  atggtg  2146



<210> 2458
<211> 640
<212> PRT
<213> Homo sapiens
<308> P13196
<400> 2458

Met Glu Ser Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln 
  1               5                  10                  15
Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn 
             20                  25                  30
Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Ala Leu 
         35                  40                  45
Ser Thr Ala Ala Val His Tyr Gln Gln Ile Lys Glu Thr Pro Pro Ala 
     50                  55                  60
Ser Glu Lys Asp Lys Thr Ala Lys Ala Lys Val Gln Gln Thr Pro Asp 
 65                  70                  75                  80
Gly Ser Gln Gln Ser Pro Asp Gly Thr Gln Leu Pro Ser Gly His Pro 
                 85                  90                  95
Leu Pro Ala Thr Ser Gln Gly Thr Ala Ser Lys Cys Pro Phe Leu Ala 
             100                105                110
Ala Gln Met Asn Gln Arg Gly Ser Ser Val Phe Cys Lys Ala Ser Leu 
         115                120                125
Glu Leu Gln Glu Asp Val Gln Glu Met Asn Ala Val Arg Lys Glu Val 
     130                135                140
Ala Glu Thr Ser Ala Gly Pro Ser Val Val Ser Val Lys Thr Asp Gly 
 145                150                155                160
Gly Asp Pro Ser Gly Leu Leu Lys Asn Phe Gln Asp Ile Met Gln Lys 
                 165                170                175
Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu Pro Lys 
             180                185                190
Ser Val Ser Thr Phe Gln Tyr Asp Arg Phe Phe Glu Lys Lys Ile Asp 
         195                200                205
Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val Asn Arg 
     210                215                220
Arg Ala His Ile Phe Pro Met Ala Asp Asp Tyr Ser Asp Ser Leu Ile 
 225                230                235                240
Thr Lys Lys Gln Val Ser Val Trp Cys Ser Asn Asp Tyr Leu Gly Met 
                 245                250                255
Ser Arg His Pro Arg Val Cys Gly Ala Val Met Asp Thr Leu Lys Gln 
             260                265                270
His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys 
         275                280                285
Phe His Val Asp Leu Glu Arg Glu Leu Ala Asp Leu His Gly Lys Asp 
     290                295                300
Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser Thr Leu 
 305                310                315                320
Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser Asp Ser 
                 325                330                335
Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg Val Pro 
             340                345                350
Lys Tyr Ile Phe Arg His Asn Asp Val Ser His Leu Arg Glu Leu Leu 
         355                360                365
Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu Thr Val 
     370                375                380
His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys Asp Val 
 385                390                395                400
Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His Ala Val 
                 405                410                415
Gly Leu Tyr Gly Ala Arg Gly Gly Gly Ile Gly Asp Arg Asp Gly Val 
             420                425                430
Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly 
         435                440                445
Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Ser Leu Ile Asp Thr Val 
     450                455                460
Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro Pro Met 
 465                470                475                480
Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser Ala Glu 
                 485                490                495
Gly Arg Val Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu Met Arg 
             500                505                510
Gln Met Leu Met Asp Ala Gly Leu Pro Val Val His Cys Pro Ser His 
         515                520                525
Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu Val Cys 
     530                535                540
Asp Glu Leu Met Ser Arg His Asn Ile Tyr Val Gln Ala Ile Asn Tyr 
 545                550                555                560
Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro Thr Pro 
                 565                570                575
His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Asn Leu Leu Val 
             580                585                590
Thr Trp Lys Gln Val Gly Leu Glu Leu Lys Pro His Ser Ser Ala Glu 
         595                600                605
Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser Glu Arg 
     610                615                620
Glu Lys Ser Tyr Phe Ser Gly Leu Ser Lys Leu Val Ser Ala Gln Ala 
 625                630                635                640



<210> 2459
<211> 2052
<212> DNA
<213> Rattus norvegicus
<308> J03190
<400> 2459

cgggacact  tgcagacat  gagactgtc  ttcgcagat  cccattctt  tcccgagtc  60
ctcaggcct  tctgcagaa  gcagggaaa  ctctgctgt  ctatgctca  aactgcccc  120
agatgatgg  agtcggggc  aagccggct  ctcggaccg  gtccacttc  gcagcacag  180
gccagcagg  caaagaaac  cctccagcc  atgagaaag  gaaaactgc  aaagccgca  240
tccagcagg  tcctgacga  tcccagatg  cacagactc  agacggcac  cagctcccg  300
ctggacacc  gtcaccctc  acaagccag  gctctggga  caagtgccc  ttcctggca  360
cacagctag  cagacgggc  gcagcgtct  ccgcaaggc  agtctggag  ttcaggagg  420
cgtggcagg  aatgcatgc  gtgaggaca  aggttgctc  aagcccagt  ctccccagc  480
tggtcaatg  aaaaaggga  ggagaaggt  caagcccac  gctgaagaa  ttccaggac  540
tcatgagaa  gcaaaggcc  gaaagagtg  ctcatcttc  tcaggataa  ttgcccaaa  600
tcgtttcca  ttttcaata  gatcatttc  ttgagaaga  aattgacga  aaaaaaaat  660
accacacct  ccgagtttt  aaaactgtg  accggagag  acagatctt  cccatggca  720
atgactaca  ggactccct  atcaccaat  atcaggtgt  ggtctggtc  agtaacgac  780
atctaggca  gagtcgaca  ccacgggtg  gtggggccg  catagagac  gtgaaacag  840
atggtgccg  tgcaggtgg  actagaaat  tttctggaa  gagcaagtt  catgtggaa  900
tggagcagg  gctggctga  ctccacggc  aggacgcgg  gctcttgtt  tcttcctgc  960
tcgtggcca  cgactccac  ctcttcacc  tggctaaga  gatgccagg  tgtgaaatt  1020
actctgatt  cgggaacca  gcctccatg  tccaaggga  tcgcaacag  cgagtgcca  1080
agtatatct  ccgccacaa  gatgtcaac  atctcagag  actgttgca  agatccgac  1140
cctcggtcc  caagatcgt  gcattcgaa  ctgtccatt  aatggatgg  gcagtgtgc  1200
ccctggaag  gctgtgtga  gtggcccat  agtttggag  gatcacgtt  gtggacgag  1260
tccatgcag  agggctcta  ggggcttca  gtggaggga  cggtgatcg  gatggagtc  1320
tgccaaaaa  ggacatcat  tctggaaca  tcggtaaag  gttcggctg  gttggagga  1380
acattgcca  cacgagttt  ctgatcgac  ccgtccggt  ctacgctgc  ggcttcatc  1440
tcaccacct  cctgccacc  atgctgctg  ctggagccc  ggagtctgt  cggatcctg  1500
agagcaatg  gggacgtgc  cttcgccgc  agcaccagc  caatgtcaa  cttatgagg  1560
agatgctaa  ggacgctgg  ctcccagtc  tccactgcc  cagccacat  atccctgtg  1620
gggttgccg  tgctgctaa  aacacagaa  tctgtgatg  gttgatgac  aggcataat  1680
tctacgtcc  ggccattaa  tacccaaca  tgcctcgtg  ggaggagct  ctccggatc  1740
cccccaccc  gcaccacac  ccgcagatg  tgaactact  cctagagaa  ctgctgctc  1800
cgtggaagc  agtcgggct  gaactgaag  cacattcgt  agctgaatg  aacttctgc  1860
ggaggccct  acacttcga  gtgatgagc  agagagaga  agcctattt  tcaggcatg  1920
gcaagatgg  gtctgccca  gcctgactg  gactcagtt  ttcacaaac  ccagaccat  1980
accataccc  aatagtagc  agaattgtc  ttagatgtg  agtaaatta  atattaaat  2040
ttaatctat  gt  2052



<210> 2460
<211> 642
<212> PRT
<213> Rattus norvegicus
<308> P13195
<400> 2460

Met Glu Thr Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln 
  1               5                  10                  15
Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn 
             20                  25                  30
Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Thr Val 
         35                  40                  45
Ser Thr Ser Ala Ala Gln Cys Gln Gln Val Lys Glu Thr Pro Pro Ala 
     50                  55                  60
Asn Glu Lys Glu Lys Thr Ala Lys Ala Ala Val Gln Gln Ala Pro Asp 
 65                  70                  75                  80
Glu Ser Gln Met Ala Gln Thr Pro Asp Gly Thr Gln Leu Pro Pro Gly 
                 85                  90                  95
His Pro Ser Pro Ser Thr Ser Gln Ser Ser Gly Ser Lys Cys Pro Phe 
             100                105                110
Leu Ala Ala Gln Leu Ala Arg Arg Ala Ala Ala Ser Ser Ala Arg Pro 
         115                120                125
Val Trp Ser Phe Arg Arg Thr Trp Gln Glu Met His Ala Val Arg Thr 
     130                135                140
Glu Val Ala Gln Ser Pro Val Leu Pro Ser Leu Val Asn Ala Lys Arg 
 145                150                155                160
Asp Gly Glu Gly Pro Ser Pro Leu Leu Lys Asn Phe Gln Asp Ile Met 
                 165                170                175
Arg Lys Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu 
             180                185                190
Pro Lys Val Val Ser Thr Phe Gln Tyr Asp His Phe Phe Glu Lys Lys 
         195                200                205
Ile Asp Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val 
     210                215                220
Asn Arg Arg Ala Gln Ile Phe Pro Met Ala Asp Asp Tyr Thr Asp Ser 
 225                230                235                240
Leu Ile Thr Asn Asn Gln Val Ser Val Trp Ser Ser Asn Asp Tyr Leu 
                 245                250                255
Gly Met Ser Arg His Pro Arg Val Cys Gly Ala Val Ile Glu Thr Val 
             260                265                270
Lys Gln His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr 
         275                280                285
Ser Lys Phe His Val Glu Leu Glu Gln Glu Leu Ala Asp Leu His Gly 
     290                295                300
Lys Asp Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser 
 305                310                315                320
Thr Leu Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser 
                 325                330                335
Asp Ser Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg 
             340                345                350
Val Pro Lys Tyr Ile Phe Arg His Asn Asp Val Asn His Leu Arg Glu 
         355                360                365
Leu Leu Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu 
     370                375                380
Thr Val His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys 
 385                390                395                400
Asp Val Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His 
                 405                410                415
Ala Val Gly Leu Tyr Gly Ala Ser Gly Gly Gly Ile Gly Asp Arg Asp 
             420                425                430
Gly Val Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala 
         435                440                445
Phe Gly Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Leu Leu Ile Asp 
     450                455                460
Thr Val Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro 
 465                470                475                480
Pro Met Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser 
                 485                490                495
Asn Glu Gly Arg Ala Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu 
             500                505                510
Met Arg Gln Met Leu Met Asp Ala Gly Leu Pro Val Ile His Cys Pro 
         515                520                525
Ser His Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu 
     530                535                540
Ile Cys Asp Glu Leu Met Thr Arg His Asn Ile Tyr Val Gln Ala Ile 
 545                550                555                560
Asn Tyr Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro 
                 565                570                575
Thr Pro His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Lys Leu 
             580                585                590
Leu Leu Thr Trp Lys Arg Val Gly Leu Glu Leu Lys Pro His Ser Ser 
         595                600                605
Ala Glu Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser 
     610                615                620
Glu Arg Glu Lys Ala Tyr Phe Ser Gly Met Ser Lys Met Val Ser Ala 
 625                630                635                640
Gln Ala 
                 645



<210> 2461
<211> 2146
<212> DNA
<213> Homo sapiens
<308> X56351
<400> 2461

agtgcccgc  tccttcgcc  ccgcctctg  agtcctcag  gcagtcttt  cacaggagc  60
agcatactt  ctgaacatg  agagtgttg  tcgccgctg  ccattctta  cccgagtcc  120
ccaggcctt  ctgcagaaa  caggcaaat  tctgttgtt  tatgcccaa  actgcccca  180
gatgatgga  gttggggcc  agccagccc  tcgggcatt  tccactgca  cagtacact  240
ccaacagat  aaagaaacc  ctccggcca  tgagaaaga  aaaactgct  aggccaagg  300
ccaacagac  cctgatgga  cccagcaga  tccagatgg  acacagctt  cgtctggac  360
ccccttgcc  gccacaagc  agggcactg  aagcaaatg  cctttcctg  cagcacaga  420
gaatcagag  ggcagcagt  tcttctgca  agccagtct  gagcttcag  aggatgtgc  480
ggaaatgaa  gccgtgagg  aagaggttg  tgaaacctc  gcaggcccc  gtgtggtta  540
tgtgaaaac  gatggaggg  atcccagtg  actgctgaa  aacttccag  acattatgc  600
aaagcaaag  ccagaaaga  tgtctcatc  tcttcaaga  aacttgcca  aatctgttt  660
cacttttca  tatgatcgt  tctttgaga  aaaaattga  gagaaaaag  atgaccaca  720
ctatcgagt  tttaaaact  tgaaccggc  agcacacat  ttccccatg  cagatgact  780
ttcagactc  ctcatcacc  aaaagcaag  gtcagtctg  tgcagtaat  actacctag  840
aatgagtcg  cacccacgg  tgtgtgggg  agttatgga  actttgaaa  aacatggtg  900
tggggcagg  ggtactaga  atatttctg  aactagtaa  ttccatgtg  acttagagc  960
ggagctggc  gacctccat  ggaaagatg  cgcactctt  ttttcctcg  gctttgtgg  1020
caatgactc  accctcttc  ccctggcta  gatgatgcc  ggctgtgag  tttactctg  1080
ttctgggaa  catgcctcc  tgatccaag  gattcgaaa  agccgagtg  caaagtaca  1140
cttccgcca  aatgatgtc  gccacctca  agaactgct  caaagatct  acccctcag  1200
ccccaagat  gtggcattt  aaactgtcc  ttcaatgga  ggggcggtg  gcccactgg  1260
agagctgtg  gatgtggcc  atgagtttg  agcaatcac  ttcgtggat  aggtccacg  1320
agtggggct  tatggggct  gaggcggag  gattgggga  cgggatgga  tcatgccaa  1380
aatggacat  atttctgga  cacttggca  agcctttgg  tgtgttgga  ggtacatcg  1440
cagcacgag  tctctgatt  acaccgtac  gtcctatgc  gctggcttc  tcttcacca  1500
ctctctgcc  cccatgctg  tggctggag  cctggagtc  gtgcggatc  tgaagagcg  1560
tgagggacg  gtgcttcgc  gccagcacc  gcgcaacgt  aaactcatg  gacagatgc  1620
aatggatgc  ggcctccct  ttgtccact  ccccagcca  atcatccct  tgcgggttg  1680
agatgctgc  aaaaacaca  aagtctgtg  tgaactaat  agcagacat  acatctacg  1740
gcaagcaat  aattaccct  cggtgcccc  gggagaaga  ctcctacgg  ttgccccca  1800
ccctcacca  acaccccag  tgatgaact  cttccttga  aatctgcta  tcacatgga  1860
gcaagtggg  ctggaactg  agcctcatt  ctcagctga  tgcaacttc  gcaggaggc  1920
actgcattt  gaagtgatg  gtgaaagag  gaagtccta  ttctcaggc  tgagcaagt  1980
ggtatctgc  caggcctga  catgacctc  attatttca  ttaacccca  gccattatc  2040
tatccagat  gtcttcaga  ttgtcttta  atgtgaatt  agttatatt  aattttaat  2100
tatagtaaa  acatagtcc  ggaaataaa  tcttgctta  atggtg  2146



<210> 2462
<211> 640
<212> PRT
<213> Homo sapiens
<308> P13196
<400> 2462

Met Glu Ser Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln 
  1               5                  10                  15
Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn 
             20                  25                  30
Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Ala Leu 
         35                  40                  45
Ser Thr Ala Ala Val His Tyr Gln Gln Ile Lys Glu Thr Pro Pro Ala 
     50                  55                  60
Ser Glu Lys Asp Lys Thr Ala Lys Ala Lys Val Gln Gln Thr Pro Asp 
 65                  70                  75                  80
Gly Ser Gln Gln Ser Pro Asp Gly Thr Gln Leu Pro Ser Gly His Pro 
                 85                  90                  95
Leu Pro Ala Thr Ser Gln Gly Thr Ala Ser Lys Cys Pro Phe Leu Ala 
             100                105                110
Ala Gln Met Asn Gln Arg Gly Ser Ser Val Phe Cys Lys Ala Ser Leu 
         115                120                125
Glu Leu Gln Glu Asp Val Gln Glu Met Asn Ala Val Arg Lys Glu Val 
     130                135                140
Ala Glu Thr Ser Ala Gly Pro Ser Val Val Ser Val Lys Thr Asp Gly 
 145                150                155                160
Gly Asp Pro Ser Gly Leu Leu Lys Asn Phe Gln Asp Ile Met Gln Lys 
                 165                170                175
Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu Pro Lys 
             180                185                190
Ser Val Ser Thr Phe Gln Tyr Asp Arg Phe Phe Glu Lys Lys Ile Asp 
         195                200                205
Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val Asn Arg 
     210                215                220
Arg Ala His Ile Phe Pro Met Ala Asp Asp Tyr Ser Asp Ser Leu Ile 
 225                230                235                240
Thr Lys Lys Gln Val Ser Val Trp Cys Ser Asn Asp Tyr Leu Gly Met 
                 245                250                255
Ser Arg His Pro Arg Val Cys Gly Ala Val Met Asp Thr Leu Lys Gln 
             260                265                270
His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys 
         275                280                285
Phe His Val Asp Leu Glu Arg Glu Leu Ala Asp Leu His Gly Lys Asp 
     290                295                300
Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser Thr Leu 
 305                310                315                320
Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser Asp Ser 
                 325                330                335
Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg Val Pro 
             340                345                350
Lys Tyr Ile Phe Arg His Asn Asp Val Ser His Leu Arg Glu Leu Leu 
         355                360                365
Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu Thr Val 
     370                375                380
His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys Asp Val 
 385                390                395                400
Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His Ala Val 
                 405                410                415
Gly Leu Tyr Gly Ala Arg Gly Gly Gly Ile Gly Asp Arg Asp Gly Val 
             420                425                430
Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly 
         435                440                445
Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Ser Leu Ile Asp Thr Val 
     450                455                460
Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro Pro Met 
 465                470                475                480
Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser Ala Glu 
                 485                490                495
Gly Arg Val Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu Met Arg 
             500                505                510
Gln Met Leu Met Asp Ala Gly Leu Pro Val Val His Cys Pro Ser His 
         515                520                525
Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu Val Cys 
     530                535                540
Asp Glu Leu Met Ser Arg His Asn Ile Tyr Val Gln Ala Ile Asn Tyr 
 545                550                555                560
Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro Thr Pro 
                 565                570                575
His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Asn Leu Leu Val 
             580                585                590
Thr Trp Lys Gln Val Gly Leu Glu Leu Lys Pro His Ser Ser Ala Glu 
         595                600                605
Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser Glu Arg 
     610                615                620
Glu Lys Ser Tyr Phe Ser Gly Leu Ser Lys Leu Val Ser Ala Gln Ala 
 625                630                635                640



<210> 2463
<211> 2052
<212> DNA
<213> Rattus norvegicus
<308> J03190
<400> 2463

cgggacact  tgcagacat  gagactgtc  ttcgcagat  cccattctt  tcccgagtc  60
ctcaggcct  tctgcagaa  gcagggaaa  ctctgctgt  ctatgctca  aactgcccc  120
agatgatgg  agtcggggc  aagccggct  ctcggaccg  gtccacttc  gcagcacag  180
gccagcagg  caaagaaac  cctccagcc  atgagaaag  gaaaactgc  aaagccgca  240
tccagcagg  tcctgacga  tcccagatg  cacagactc  agacggcac  cagctcccg  300
ctggacacc  gtcaccctc  acaagccag  gctctggga  caagtgccc  ttcctggca  360
cacagctag  cagacgggc  gcagcgtct  ccgcaaggc  agtctggag  ttcaggagg  420
cgtggcagg  aatgcatgc  gtgaggaca  aggttgctc  aagcccagt  ctccccagc  480
tggtcaatg  aaaaaggga  ggagaaggt  caagcccac  gctgaagaa  ttccaggac  540
tcatgagaa  gcaaaggcc  gaaagagtg  ctcatcttc  tcaggataa  ttgcccaaa  600
tcgtttcca  ttttcaata  gatcatttc  ttgagaaga  aattgacga  aaaaaaaat  660
accacacct  ccgagtttt  aaaactgtg  accggagag  acagatctt  cccatggca  720
atgactaca  ggactccct  atcaccaat  atcaggtgt  ggtctggtc  agtaacgac  780
atctaggca  gagtcgaca  ccacgggtg  gtggggccg  catagagac  gtgaaacag  840
atggtgccg  tgcaggtgg  actagaaat  tttctggaa  gagcaagtt  catgtggaa  900
tggagcagg  gctggctga  ctccacggc  aggacgcgg  gctcttgtt  tcttcctgc  960
tcgtggcca  cgactccac  ctcttcacc  tggctaaga  gatgccagg  tgtgaaatt  1020
actctgatt  cgggaacca  gcctccatg  tccaaggga  tcgcaacag  cgagtgcca  1080
agtatatct  ccgccacaa  gatgtcaac  atctcagag  actgttgca  agatccgac  1140
cctcggtcc  caagatcgt  gcattcgaa  ctgtccatt  aatggatgg  gcagtgtgc  1200
ccctggaag  gctgtgtga  gtggcccat  agtttggag  gatcacgtt  gtggacgag  1260
tccatgcag  agggctcta  ggggcttca  gtggaggga  cggtgatcg  gatggagtc  1320
tgccaaaaa  ggacatcat  tctggaaca  tcggtaaag  gttcggctg  gttggagga  1380
acattgcca  cacgagttt  ctgatcgac  ccgtccggt  ctacgctgc  ggcttcatc  1440
tcaccacct  cctgccacc  atgctgctg  ctggagccc  ggagtctgt  cggatcctg  1500
agagcaatg  gggacgtgc  cttcgccgc  agcaccagc  caatgtcaa  cttatgagg  1560
agatgctaa  ggacgctgg  ctcccagtc  tccactgcc  cagccacat  atccctgtg  1620
gggttgccg  tgctgctaa  aacacagaa  tctgtgatg  gttgatgac  aggcataat  1680
tctacgtcc  ggccattaa  tacccaaca  tgcctcgtg  ggaggagct  ctccggatc  1740
cccccaccc  gcaccacac  ccgcagatg  tgaactact  cctagagaa  ctgctgctc  1800
cgtggaagc  agtcgggct  gaactgaag  cacattcgt  agctgaatg  aacttctgc  1860
ggaggccct  acacttcga  gtgatgagc  agagagaga  agcctattt  tcaggcatg  1920
gcaagatgg  gtctgccca  gcctgactg  gactcagtt  ttcacaaac  ccagaccat  1980
accataccc  aatagtagc  agaattgtc  ttagatgtg  agtaaatta  atattaaat  2040
ttaatctat  gt  2052



<210> 2464
<211> 642
<212> PRT
<213> Rattus norvegicus
<308> P13195
<400> 2464

Met Glu Thr Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln 
  1               5                  10                  15
Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn 
             20                  25                  30
Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Thr Val 
         35                  40                  45
Ser Thr Ser Ala Ala Gln Cys Gln Gln Val Lys Glu Thr Pro Pro Ala 
     50                  55                  60
Asn Glu Lys Glu Lys Thr Ala Lys Ala Ala Val Gln Gln Ala Pro Asp 
 65                  70                  75                  80
Glu Ser Gln Met Ala Gln Thr Pro Asp Gly Thr Gln Leu Pro Pro Gly 
                 85                  90                  95
His Pro Ser Pro Ser Thr Ser Gln Ser Ser Gly Ser Lys Cys Pro Phe 
             100                105                110
Leu Ala Ala Gln Leu Ala Arg Arg Ala Ala Ala Ser Ser Ala Arg Pro 
         115                120                125
Val Trp Ser Phe Arg Arg Thr Trp Gln Glu Met His Ala Val Arg Thr 
     130                135                140
Glu Val Ala Gln Ser Pro Val Leu Pro Ser Leu Val Asn Ala Lys Arg 
 145                150                155                160
Asp Gly Glu Gly Pro Ser Pro Leu Leu Lys Asn Phe Gln Asp Ile Met 
                 165                170                175
Arg Lys Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu 
             180                185                190
Pro Lys Val Val Ser Thr Phe Gln Tyr Asp His Phe Phe Glu Lys Lys 
         195                200                205
Ile Asp Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val 
     210                215                220
Asn Arg Arg Ala Gln Ile Phe Pro Met Ala Asp Asp Tyr Thr Asp Ser 
 225                230                235                240
Leu Ile Thr Asn Asn Gln Val Ser Val Trp Ser Ser Asn Asp Tyr Leu 
                 245                250                255
Gly Met Ser Arg His Pro Arg Val Cys Gly Ala Val Ile Glu Thr Val 
             260                265                270
Lys Gln His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr 
         275                280                285
Ser Lys Phe His Val Glu Leu Glu Gln Glu Leu Ala Asp Leu His Gly 
     290                295                300
Lys Asp Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser 
 305                310                315                320
Thr Leu Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser 
                 325                330                335
Asp Ser Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg 
             340                345                350
Val Pro Lys Tyr Ile Phe Arg His Asn Asp Val Asn His Leu Arg Glu 
         355                360                365
Leu Leu Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu 
     370                375                380
Thr Val His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys 
 385                390                395                400
Asp Val Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His 
                 405                410                415
Ala Val Gly Leu Tyr Gly Ala Ser Gly Gly Gly Ile Gly Asp Arg Asp 
             420                425                430
Gly Val Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala 
         435                440                445
Phe Gly Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Leu Leu Ile Asp 
     450                455                460
Thr Val Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro 
 465                470                475                480
Pro Met Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser 
                 485                490                495
Asn Glu Gly Arg Ala Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu 
             500                505                510
Met Arg Gln Met Leu Met Asp Ala Gly Leu Pro Val Ile His Cys Pro 
         515                520                525
Ser His Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu 
     530                535                540
Ile Cys Asp Glu Leu Met Thr Arg His Asn Ile Tyr Val Gln Ala Ile 
 545                550                555                560
Asn Tyr Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro 
                 565                570                575
Thr Pro His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Lys Leu 
             580                585                590
Leu Leu Thr Trp Lys Arg Val Gly Leu Glu Leu Lys Pro His Ser Ser 
         595                600                605
Ala Glu Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser 
     610                615                620
Glu Arg Glu Lys Ala Tyr Phe Ser Gly Met Ser Lys Met Val Ser Ala 
 625                630                635                640
Gln Ala 
                 645



<210> 2465
<211> 2146
<212> DNA
<213> Homo sapiens
<308> X56351
<400> 2465

agtgcccgc  tccttcgcc  ccgcctctg  agtcctcag  gcagtcttt  cacaggagc  60
agcatactt  ctgaacatg  agagtgttg  tcgccgctg  ccattctta  cccgagtcc  120
ccaggcctt  ctgcagaaa  caggcaaat  tctgttgtt  tatgcccaa  actgcccca  180
gatgatgga  gttggggcc  agccagccc  tcgggcatt  tccactgca  cagtacact  240
ccaacagat  aaagaaacc  ctccggcca  tgagaaaga  aaaactgct  aggccaagg  300
ccaacagac  cctgatgga  cccagcaga  tccagatgg  acacagctt  cgtctggac  360
ccccttgcc  gccacaagc  agggcactg  aagcaaatg  cctttcctg  cagcacaga  420
gaatcagag  ggcagcagt  tcttctgca  agccagtct  gagcttcag  aggatgtgc  480
ggaaatgaa  gccgtgagg  aagaggttg  tgaaacctc  gcaggcccc  gtgtggtta  540
tgtgaaaac  gatggaggg  atcccagtg  actgctgaa  aacttccag  acattatgc  600
aaagcaaag  ccagaaaga  tgtctcatc  tcttcaaga  aacttgcca  aatctgttt  660
cacttttca  tatgatcgt  tctttgaga  aaaaattga  gagaaaaag  atgaccaca  720
ctatcgagt  tttaaaact  tgaaccggc  agcacacat  ttccccatg  cagatgact  780
ttcagactc  ctcatcacc  aaaagcaag  gtcagtctg  tgcagtaat  actacctag  840
aatgagtcg  cacccacgg  tgtgtgggg  agttatgga  actttgaaa  aacatggtg  900
tggggcagg  ggtactaga  atatttctg  aactagtaa  ttccatgtg  acttagagc  960
ggagctggc  gacctccat  ggaaagatg  cgcactctt  ttttcctcg  gctttgtgg  1020
caatgactc  accctcttc  ccctggcta  gatgatgcc  ggctgtgag  tttactctg  1080
ttctgggaa  catgcctcc  tgatccaag  gattcgaaa  agccgagtg  caaagtaca  1140
cttccgcca  aatgatgtc  gccacctca  agaactgct  caaagatct  acccctcag  1200
ccccaagat  gtggcattt  aaactgtcc  ttcaatgga  ggggcggtg  gcccactgg  1260
agagctgtg  gatgtggcc  atgagtttg  agcaatcac  ttcgtggat  aggtccacg  1320
agtggggct  tatggggct  gaggcggag  gattgggga  cgggatgga  tcatgccaa  1380
aatggacat  atttctgga  cacttggca  agcctttgg  tgtgttgga  ggtacatcg  1440
cagcacgag  tctctgatt  acaccgtac  gtcctatgc  gctggcttc  tcttcacca  1500
ctctctgcc  cccatgctg  tggctggag  cctggagtc  gtgcggatc  tgaagagcg  1560
tgagggacg  gtgcttcgc  gccagcacc  gcgcaacgt  aaactcatg  gacagatgc  1620
aatggatgc  ggcctccct  ttgtccact  ccccagcca  atcatccct  tgcgggttg  1680
agatgctgc  aaaaacaca  aagtctgtg  tgaactaat  agcagacat  acatctacg  1740
gcaagcaat  aattaccct  cggtgcccc  gggagaaga  ctcctacgg  ttgccccca  1800
ccctcacca  acaccccag  tgatgaact  cttccttga  aatctgcta  tcacatgga  1860
gcaagtggg  ctggaactg  agcctcatt  ctcagctga  tgcaacttc  gcaggaggc  1920
actgcattt  gaagtgatg  gtgaaagag  gaagtccta  ttctcaggc  tgagcaagt  1980
ggtatctgc  caggcctga  catgacctc  attatttca  ttaacccca  gccattatc  2040
tatccagat  gtcttcaga  ttgtcttta  atgtgaatt  agttatatt  aattttaat  2100
tatagtaaa  acatagtcc  ggaaataaa  tcttgctta  atggtg  2146



<210> 2466
<211> 640
<212> PRT
<213> Homo sapiens
<308> P13196
<400> 2466

Met Glu Ser Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln 
  1               5                  10                  15
Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn 
             20                  25                  30
Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Ala Leu 
         35                  40                  45
Ser Thr Ala Ala Val His Tyr Gln Gln Ile Lys Glu Thr Pro Pro Ala 
     50                  55                  60
Ser Glu Lys Asp Lys Thr Ala Lys Ala Lys Val Gln Gln Thr Pro Asp 
 65                  70                  75                  80
Gly Ser Gln Gln Ser Pro Asp Gly Thr Gln Leu Pro Ser Gly His Pro 
                 85                  90                  95
Leu Pro Ala Thr Ser Gln Gly Thr Ala Ser Lys Cys Pro Phe Leu Ala 
             100                105                110
Ala Gln Met Asn Gln Arg Gly Ser Ser Val Phe Cys Lys Ala Ser Leu 
         115                120                125
Glu Leu Gln Glu Asp Val Gln Glu Met Asn Ala Val Arg Lys Glu Val 
     130                135                140
Ala Glu Thr Ser Ala Gly Pro Ser Val Val Ser Val Lys Thr Asp Gly 
 145                150                155                160
Gly Asp Pro Ser Gly Leu Leu Lys Asn Phe Gln Asp Ile Met Gln Lys 
                 165                170                175
Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu Pro Lys 
             180                185                190
Ser Val Ser Thr Phe Gln Tyr Asp Arg Phe Phe Glu Lys Lys Ile Asp 
         195                200                205
Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val Asn Arg 
     210                215                220
Arg Ala His Ile Phe Pro Met Ala Asp Asp Tyr Ser Asp Ser Leu Ile 
 225                230                235                240
Thr Lys Lys Gln Val Ser Val Trp Cys Ser Asn Asp Tyr Leu Gly Met 
                 245                250                255
Ser Arg His Pro Arg Val Cys Gly Ala Val Met Asp Thr Leu Lys Gln 
             260                265                270
His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys 
         275                280                285
Phe His Val Asp Leu Glu Arg Glu Leu Ala Asp Leu His Gly Lys Asp 
     290                295                300
Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser Thr Leu 
 305                310                315                320
Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser Asp Ser 
                 325                330                335
Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg Val Pro 
             340                345                350
Lys Tyr Ile Phe Arg His Asn Asp Val Ser His Leu Arg Glu Leu Leu 
         355                360                365
Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu Thr Val 
     370                375                380
His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys Asp Val 
 385                390                395                400
Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His Ala Val 
                 405                410                415
Gly Leu Tyr Gly Ala Arg Gly Gly Gly Ile Gly Asp Arg Asp Gly Val 
             420                425                430
Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly 
         435                440                445
Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Ser Leu Ile Asp Thr Val 
     450                455                460
Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro Pro Met 
 465                470                475                480
Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser Ala Glu 
                 485                490                495
Gly Arg Val Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu Met Arg 
             500                505                510
Gln Met Leu Met Asp Ala Gly Leu Pro Val Val His Cys Pro Ser His 
         515                520                525
Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu Val Cys 
     530                535                540
Asp Glu Leu Met Ser Arg His Asn Ile Tyr Val Gln Ala Ile Asn Tyr 
 545                550                555                560
Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro Thr Pro 
                 565                570                575
His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Asn Leu Leu Val 
             580                585                590
Thr Trp Lys Gln Val Gly Leu Glu Leu Lys Pro His Ser Ser Ala Glu 
         595                600                605
Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser Glu Arg 
     610                615                620
Glu Lys Ser Tyr Phe Ser Gly Leu Ser Lys Leu Val Ser Ala Gln Ala 
 625                630                635                640



<210> 2467
<211> 1307
<212> DNA
<213> Rattus norvegicus
<308> J03481
<400> 2467

gtgcttttg  gtttggcga  cagttccgc  ggagtcttg  caggagcag  atggcggct  60
cgggcgagg  gcgccgagt  ctggtgtac  gcggcaggg  tgctctggg  tcgcgctgc  120
tacaggcct  ccgggcccg  aactggtgg  ttgccagca  tgatgtggt  gagaatgaa  180
aggccagtg  cagcgtgat  gttaagatg  cagattcat  cacggagca  gctgaccag  240
tcactgctg  ggtcgggaa  ctcctaggt  accagaagg  ggatgccat  ctctgtgtg  300
ctggaggat  ggccggggg  aatgccaaa  ccaagtcac  ctttaaaaa  tgtgacctg  360
tgtggaagc  gagtatttg  acatccacc  tctctagcc  cttggccac  aagcacctg  420
aggaaggag  cctcttgac  ctggccggg  ccaaagctg  gttggatgg  actcctggg  480
tgattggct  cggcatggc  aagggagcc  tccatcagc  ctgccagag  cttgcaggg  540
agaacagtg  catgccgtc  ggggctgcc  ccattgctg  gcttcccgt  accctggat  600
ctccgatga  caggaaatc  atgcccgag  cagacttca  ctcctggac  cccttagag  660
tcctggtgg  gaccttcca  gactggatc  ctgggaaca  acggccaaa  tcaggaagc  720
taatccagg  ggtaaccac  gacgggaag  cagagctta  tccagccta  ttctaagtt  780
cacctcagt  cccaggaga  ccctcttga  actctacta  cctgtgtct  tattgccgc  840
cctggcccc  tgttgtctg  attcctgtt  gtggtacga  ataactagt  ccgtttgtc  900
cttacgtag  gctcctttt  tgtcctggg  tggtgaggt  tgtttatgg  gaatgagtg  960
gggcctgta  gtagcacca  cagtgctga  gcccaggga  gtatgtgtg  aggccgtca  1020
cccagcatc  cagactgct  tggagaccc  tttgatagt  catttttta  catttgggg  1080
actttgaaa  ccaacttgt  tttaaattc  atgttagtg  catagatgt  gtttttgct  1140
cctgaaaat  aactgccat  aaaattcat  ggtgatgta  gtaagcaaa  cctaatgga  1200
tctgttgga  atcatttgt  ttccagcct  ggctaagtg  ttatgagaa  tattcgtga  1260
tgttcggag  gttcttcct  ataaacaca  ttcatgtcc  cgaattc  1307



<210> 2468
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> P11348
<400> 2468

Met Ala Ala Ser Gly Glu Ala Arg Arg Val Leu Val Tyr Gly Gly Arg 
  1               5                  10                  15
Gly Ala Leu Gly Ser Arg Cys Val Gln Ala Phe Arg Ala Arg Asn Trp 
             20                  25                  30
Trp Val Ala Ser Ile Asp Val Val Glu Asn Glu Glu Ala Ser Ala Ser 
         35                  40                  45
Val Ile Val Lys Met Thr Asp Ser Phe Thr Glu Gln Ala Asp Gln Val 
     50                  55                  60
Thr Ala Glu Val Gly Lys Leu Leu Gly Asp Gln Lys Val Asp Ala Ile 
 65                  70                  75                  80
Leu Cys Val Ala Gly Gly Trp Ala Gly Gly Asn Ala Lys Ser Lys Ser 
                 85                  90                  95
Leu Phe Lys Asn Cys Asp Leu Met Trp Lys Gln Ser Ile Trp Thr Ser 
             100                105                110
Thr Ile Ser Ser His Leu Ala Thr Lys His Leu Lys Glu Gly Gly Leu 
         115                120                125
Leu Thr Leu Ala Gly Ala Lys Ala Ala Leu Asp Gly Thr Pro Gly Met 
     130                135                140
Ile Gly Tyr Gly Met Ala Lys Gly Ala Val His Gln Leu Cys Gln Ser 
 145                150                155                160
Leu Ala Gly Lys Asn Ser Gly Met Pro Ser Gly Ala Ala Ala Ile Ala 
                 165                170                175
Val Leu Pro Val Thr Leu Asp Thr Pro Met Asn Arg Lys Ser Met Pro 
             180                185                190
Glu Ala Asp Phe Ser Ser Trp Thr Pro Leu Glu Phe Leu Val Glu Thr 
         195                200                205
Phe His Asp Trp Ile Thr Gly Asn Lys Arg Pro Asn Ser Gly Ser Leu 
     210                215                220
Ile Gln Val Val Thr Thr Asp Gly Lys Thr Glu Leu Thr Pro Ala Tyr 
 225                230                235                240
Phe 
                 245



<210> 2469
<211> 1394
<212> DNA
<213> Homo sapiens
<308> BC000576
<400> 2469

ggcacgagg  ggagccggg  tggcaggag  aggatggcg  cggcggcgg  tgcaggcga  60
gcgcgccgg  tgctggtgt  cggcggcag  ggcgctctg  gttctcgat  cgtgcaggc  120
tttcgggcc  gcaactggt  ggttgccag  gttgatgtg  tggagaatg  agaggccag  180
gctagcatc  ttgttaaaa  gacagactc  ttcactgag  aggctgacc  ggtgactgc  240
gaggttgga  agctcttgg  tgaagagaa  gtggatgca  ttctttgcg  tgctggagg  300
tgggccggg  gcaatgcca  atccaagtc  ctctttaag  actgtgacc  gatgtggaa  360
cagagcata  ggacatcga  catctccag  catctggct  ccaagcatc  caaggaagg  420
ggcctcctg  ccttggctg  cgcaaaggc  gccctggat  ggactcctg  tatgatcgg  480
tacggcatg  ccaagggtg  tgttcacca  ctctgccag  gcctggctg  gaagaacag  540
ggcatgccg  ccggggcag  cgccatcgc  gtgctcccg  ttaccctgg  taccccgat  600
aacaggaaa  caatgcctg  ggctgactt  agctcctgg  cacccttag  attcctagt  660
gaaactttc  atgactgga  cacagggaa  aaccgaccg  gctcaggaa  cctaatcca  720
gtggtaacc  cagaaggaa  gacggaact  accccagca  atttttagg  ctcatctca  780
tgcctatga  gggcctgcc  gaaaagtca  taacctgtc  cagtgtggc  ttgtccagc  840
ttgtgtttt  tgtaacccc  gtttgtggt  cgagataat  agtcctatt  ttctctcac  900
taatatgca  ttgctctcc  aggacagtg  aatacattt  tgtgaagta  agacatgcg  960
gactggtgg  ctgcaaata  catccgtca  tctgtgtta  ctgcatagg  agggctctg  1020
atagcacct  ctatagcgg  gtcatgttg  atcgctttt  tgactgttc  tctgtcctt  1080
acagtggct  tcatcttga  tactttgtt  atttgttgg  attggggac  ttttaaagg  1140
tgagttatt  ttgaatgtc  tgtttatgt  atagacgta  ttttcgcat  cttgaatta  1200
actgcctta  ctccttttg  ggtataagc  aaactccat  gactctgtc  tggtatcct  1260
ttcctgtgt  gttgccctg  gtcctctgg  ctagggtta  gtgtgcaag  taactactc  1320
tgagtattc  gaatgttgt  cctaataaa  gcacttgtt  tctgtcttc  ttaaaaaaa  1380
aaaaaaaaa  aaaa  1394



<210> 2470
<211> 244
<212> PRT
<213> Homo sapiens
<308> P09417
<400> 2470

Met Ala Ala Ala Ala Ala Ala Gly Glu Ala Arg Arg Val Leu Val Tyr 
  1               5                  10                  15
Gly Gly Arg Gly Ala Leu Gly Ser Arg Cys Val Gln Ala Phe Arg Ala 
             20                  25                  30
Arg Asn Trp Trp Val Ala Ser Val Asp Val Val Glu Asn Glu Glu Ala 
         35                  40                  45
Ser Ala Thr Ile Ile Val Lys Met Thr Asp Ser Phe Thr Glu Gln Ala 
     50                  55                  60
Asp Gln Val Thr Ala Glu Val Gly Lys Leu Leu Gly Glu Glu Lys Val 
 65                  70                  75                  80
Asp Ala Ile Leu Cys Val Ala Gly Gly Trp Ala Gly Gly Asn Ala Lys 
                 85                  90                  95
Ser Lys Ser Leu Phe Lys Asn Cys Asp Leu Met Trp Lys Gln Ser Ile 
             100                105                110
Trp Thr Ser Thr Ile Ser Ser His Leu Ala Thr Lys His Leu Lys Glu 
         115                120                125
Gly Gly Leu Leu Thr Leu Ala Gly Ala Lys Ala Ala Leu Asp Gly Thr 
     130                135                140
Pro Gly Met Ile Gly Tyr Gly Met Ala Lys Gly Ala Val His Gln Leu 
 145                150                155                160
Cys Gln Ser Leu Ala Gly Lys Asn Ser Gly Met Pro Pro Gly Ala Ala 
                 165                170                175
Ala Ile Ala Val Leu Pro Val Thr Leu Asp Thr Pro Met Asn Arg Lys 
             180                185                190
Ser Met Pro Glu Ala Asp Phe Ser Ser Trp Thr Pro Leu Glu Phe Leu 
         195                200                205
Val Glu Thr Phe His Asp Trp Ile Thr Gly Lys Asn Arg Pro Ser Ser 
     210                215                220
Gly Ser Leu Ile Gln Val Val Thr Thr Glu Gly Arg Thr Glu Leu Thr 
 225                230                235                240
Pro Ala Tyr Phe 
                 245



<210> 2471
<211> 1307
<212> DNA
<213> Rattus norvegicus
<308> J03481
<400> 2471

gtgcttttg  gtttggcga  cagttccgc  ggagtcttg  caggagcag  atggcggct  60
cgggcgagg  gcgccgagt  ctggtgtac  gcggcaggg  tgctctggg  tcgcgctgc  120
tacaggcct  ccgggcccg  aactggtgg  ttgccagca  tgatgtggt  gagaatgaa  180
aggccagtg  cagcgtgat  gttaagatg  cagattcat  cacggagca  gctgaccag  240
tcactgctg  ggtcgggaa  ctcctaggt  accagaagg  ggatgccat  ctctgtgtg  300
ctggaggat  ggccggggg  aatgccaaa  ccaagtcac  ctttaaaaa  tgtgacctg  360
tgtggaagc  gagtatttg  acatccacc  tctctagcc  cttggccac  aagcacctg  420
aggaaggag  cctcttgac  ctggccggg  ccaaagctg  gttggatgg  actcctggg  480
tgattggct  cggcatggc  aagggagcc  tccatcagc  ctgccagag  cttgcaggg  540
agaacagtg  catgccgtc  ggggctgcc  ccattgctg  gcttcccgt  accctggat  600
ctccgatga  caggaaatc  atgcccgag  cagacttca  ctcctggac  cccttagag  660
tcctggtgg  gaccttcca  gactggatc  ctgggaaca  acggccaaa  tcaggaagc  720
taatccagg  ggtaaccac  gacgggaag  cagagctta  tccagccta  ttctaagtt  780
cacctcagt  cccaggaga  ccctcttga  actctacta  cctgtgtct  tattgccgc  840
cctggcccc  tgttgtctg  attcctgtt  gtggtacga  ataactagt  ccgtttgtc  900
cttacgtag  gctcctttt  tgtcctggg  tggtgaggt  tgtttatgg  gaatgagtg  960
gggcctgta  gtagcacca  cagtgctga  gcccaggga  gtatgtgtg  aggccgtca  1020
cccagcatc  cagactgct  tggagaccc  tttgatagt  catttttta  catttgggg  1080
actttgaaa  ccaacttgt  tttaaattc  atgttagtg  catagatgt  gtttttgct  1140
cctgaaaat  aactgccat  aaaattcat  ggtgatgta  gtaagcaaa  cctaatgga  1200
tctgttgga  atcatttgt  ttccagcct  ggctaagtg  ttatgagaa  tattcgtga  1260
tgttcggag  gttcttcct  ataaacaca  ttcatgtcc  cgaattc  1307



<210> 2472
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> P11348
<400> 2472

Met Ala Ala Ser Gly Glu Ala Arg Arg Val Leu Val Tyr Gly Gly Arg 
  1               5                  10                  15
Gly Ala Leu Gly Ser Arg Cys Val Gln Ala Phe Arg Ala Arg Asn Trp 
             20                  25                  30
Trp Val Ala Ser Ile Asp Val Val Glu Asn Glu Glu Ala Ser Ala Ser 
         35                  40                  45
Val Ile Val Lys Met Thr Asp Ser Phe Thr Glu Gln Ala Asp Gln Val 
     50                  55                  60
Thr Ala Glu Val Gly Lys Leu Leu Gly Asp Gln Lys Val Asp Ala Ile 
 65                  70                  75                  80
Leu Cys Val Ala Gly Gly Trp Ala Gly Gly Asn Ala Lys Ser Lys Ser 
                 85                  90                  95
Leu Phe Lys Asn Cys Asp Leu Met Trp Lys Gln Ser Ile Trp Thr Ser 
             100                105                110
Thr Ile Ser Ser His Leu Ala Thr Lys His Leu Lys Glu Gly Gly Leu 
         115                120                125
Leu Thr Leu Ala Gly Ala Lys Ala Ala Leu Asp Gly Thr Pro Gly Met 
     130                135                140
Ile Gly Tyr Gly Met Ala Lys Gly Ala Val His Gln Leu Cys Gln Ser 
 145                150                155                160
Leu Ala Gly Lys Asn Ser Gly Met Pro Ser Gly Ala Ala Ala Ile Ala 
                 165                170                175
Val Leu Pro Val Thr Leu Asp Thr Pro Met Asn Arg Lys Ser Met Pro 
             180                185                190
Glu Ala Asp Phe Ser Ser Trp Thr Pro Leu Glu Phe Leu Val Glu Thr 
         195                200                205
Phe His Asp Trp Ile Thr Gly Asn Lys Arg Pro Asn Ser Gly Ser Leu 
     210                215                220
Ile Gln Val Val Thr Thr Asp Gly Lys Thr Glu Leu Thr Pro Ala Tyr 
 225                230                235                240
Phe 
                 245



<210> 2473
<211> 1394
<212> DNA
<213> Homo sapiens
<308> BC000576
<400> 2473

ggcacgagg  ggagccggg  tggcaggag  aggatggcg  cggcggcgg  tgcaggcga  60
gcgcgccgg  tgctggtgt  cggcggcag  ggcgctctg  gttctcgat  cgtgcaggc  120
tttcgggcc  gcaactggt  ggttgccag  gttgatgtg  tggagaatg  agaggccag  180
gctagcatc  ttgttaaaa  gacagactc  ttcactgag  aggctgacc  ggtgactgc  240
gaggttgga  agctcttgg  tgaagagaa  gtggatgca  ttctttgcg  tgctggagg  300
tgggccggg  gcaatgcca  atccaagtc  ctctttaag  actgtgacc  gatgtggaa  360
cagagcata  ggacatcga  catctccag  catctggct  ccaagcatc  caaggaagg  420
ggcctcctg  ccttggctg  cgcaaaggc  gccctggat  ggactcctg  tatgatcgg  480
tacggcatg  ccaagggtg  tgttcacca  ctctgccag  gcctggctg  gaagaacag  540
ggcatgccg  ccggggcag  cgccatcgc  gtgctcccg  ttaccctgg  taccccgat  600
aacaggaaa  caatgcctg  ggctgactt  agctcctgg  cacccttag  attcctagt  660
gaaactttc  atgactgga  cacagggaa  aaccgaccg  gctcaggaa  cctaatcca  720
gtggtaacc  cagaaggaa  gacggaact  accccagca  atttttagg  ctcatctca  780
tgcctatga  gggcctgcc  gaaaagtca  taacctgtc  cagtgtggc  ttgtccagc  840
ttgtgtttt  tgtaacccc  gtttgtggt  cgagataat  agtcctatt  ttctctcac  900
taatatgca  ttgctctcc  aggacagtg  aatacattt  tgtgaagta  agacatgcg  960
gactggtgg  ctgcaaata  catccgtca  tctgtgtta  ctgcatagg  agggctctg  1020
atagcacct  ctatagcgg  gtcatgttg  atcgctttt  tgactgttc  tctgtcctt  1080
acagtggct  tcatcttga  tactttgtt  atttgttgg  attggggac  ttttaaagg  1140
tgagttatt  ttgaatgtc  tgtttatgt  atagacgta  ttttcgcat  cttgaatta  1200
actgcctta  ctccttttg  ggtataagc  aaactccat  gactctgtc  tggtatcct  1260
ttcctgtgt  gttgccctg  gtcctctgg  ctagggtta  gtgtgcaag  taactactc  1320
tgagtattc  gaatgttgt  cctaataaa  gcacttgtt  tctgtcttc  ttaaaaaaa  1380
aaaaaaaaa  aaaa  1394



<210> 2474
<211> 244
<212> PRT
<213> Homo sapiens
<308> P09417
<400> 2474

Met Ala Ala Ala Ala Ala Ala Gly Glu Ala Arg Arg Val Leu Val Tyr 
  1               5                  10                  15
Gly Gly Arg Gly Ala Leu Gly Ser Arg Cys Val Gln Ala Phe Arg Ala 
             20                  25                  30
Arg Asn Trp Trp Val Ala Ser Val Asp Val Val Glu Asn Glu Glu Ala 
         35                  40                  45
Ser Ala Thr Ile Ile Val Lys Met Thr Asp Ser Phe Thr Glu Gln Ala 
     50                  55                  60
Asp Gln Val Thr Ala Glu Val Gly Lys Leu Leu Gly Glu Glu Lys Val 
 65                  70                  75                  80
Asp Ala Ile Leu Cys Val Ala Gly Gly Trp Ala Gly Gly Asn Ala Lys 
                 85                  90                  95
Ser Lys Ser Leu Phe Lys Asn Cys Asp Leu Met Trp Lys Gln Ser Ile 
             100                105                110
Trp Thr Ser Thr Ile Ser Ser His Leu Ala Thr Lys His Leu Lys Glu 
         115                120                125
Gly Gly Leu Leu Thr Leu Ala Gly Ala Lys Ala Ala Leu Asp Gly Thr 
     130                135                140
Pro Gly Met Ile Gly Tyr Gly Met Ala Lys Gly Ala Val His Gln Leu 
 145                150                155                160
Cys Gln Ser Leu Ala Gly Lys Asn Ser Gly Met Pro Pro Gly Ala Ala 
                 165                170                175
Ala Ile Ala Val Leu Pro Val Thr Leu Asp Thr Pro Met Asn Arg Lys 
             180                185                190
Ser Met Pro Glu Ala Asp Phe Ser Ser Trp Thr Pro Leu Glu Phe Leu 
         195                200                205
Val Glu Thr Phe His Asp Trp Ile Thr Gly Lys Asn Arg Pro Ser Ser 
     210                215                220
Gly Ser Leu Ile Gln Val Val Thr Thr Glu Gly Arg Thr Glu Leu Thr 
 225                230                235                240
Pro Ala Tyr Phe 
                 245



<210> 2475
<211> 1307
<212> DNA
<213> Rattus norvegicus
<308> J03481
<400> 2475

gtgcttttg  gtttggcga  cagttccgc  ggagtcttg  caggagcag  atggcggct  60
cgggcgagg  gcgccgagt  ctggtgtac  gcggcaggg  tgctctggg  tcgcgctgc  120
tacaggcct  ccgggcccg  aactggtgg  ttgccagca  tgatgtggt  gagaatgaa  180
aggccagtg  cagcgtgat  gttaagatg  cagattcat  cacggagca  gctgaccag  240
tcactgctg  ggtcgggaa  ctcctaggt  accagaagg  ggatgccat  ctctgtgtg  300
ctggaggat  ggccggggg  aatgccaaa  ccaagtcac  ctttaaaaa  tgtgacctg  360
tgtggaagc  gagtatttg  acatccacc  tctctagcc  cttggccac  aagcacctg  420
aggaaggag  cctcttgac  ctggccggg  ccaaagctg  gttggatgg  actcctggg  480
tgattggct  cggcatggc  aagggagcc  tccatcagc  ctgccagag  cttgcaggg  540
agaacagtg  catgccgtc  ggggctgcc  ccattgctg  gcttcccgt  accctggat  600
ctccgatga  caggaaatc  atgcccgag  cagacttca  ctcctggac  cccttagag  660
tcctggtgg  gaccttcca  gactggatc  ctgggaaca  acggccaaa  tcaggaagc  720
taatccagg  ggtaaccac  gacgggaag  cagagctta  tccagccta  ttctaagtt  780
cacctcagt  cccaggaga  ccctcttga  actctacta  cctgtgtct  tattgccgc  840
cctggcccc  tgttgtctg  attcctgtt  gtggtacga  ataactagt  ccgtttgtc  900
cttacgtag  gctcctttt  tgtcctggg  tggtgaggt  tgtttatgg  gaatgagtg  960
gggcctgta  gtagcacca  cagtgctga  gcccaggga  gtatgtgtg  aggccgtca  1020
cccagcatc  cagactgct  tggagaccc  tttgatagt  catttttta  catttgggg  1080
actttgaaa  ccaacttgt  tttaaattc  atgttagtg  catagatgt  gtttttgct  1140
cctgaaaat  aactgccat  aaaattcat  ggtgatgta  gtaagcaaa  cctaatgga  1200
tctgttgga  atcatttgt  ttccagcct  ggctaagtg  ttatgagaa  tattcgtga  1260
tgttcggag  gttcttcct  ataaacaca  ttcatgtcc  cgaattc  1307



<210> 2476
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> P11348
<400> 2476

Met Ala Ala Ser Gly Glu Ala Arg Arg Val Leu Val Tyr Gly Gly Arg 
  1               5                  10                  15
Gly Ala Leu Gly Ser Arg Cys Val Gln Ala Phe Arg Ala Arg Asn Trp 
             20                  25                  30
Trp Val Ala Ser Ile Asp Val Val Glu Asn Glu Glu Ala Ser Ala Ser 
         35                  40                  45
Val Ile Val Lys Met Thr Asp Ser Phe Thr Glu Gln Ala Asp Gln Val 
     50                  55                  60
Thr Ala Glu Val Gly Lys Leu Leu Gly Asp Gln Lys Val Asp Ala Ile 
 65                  70                  75                  80
Leu Cys Val Ala Gly Gly Trp Ala Gly Gly Asn Ala Lys Ser Lys Ser 
                 85                  90                  95
Leu Phe Lys Asn Cys Asp Leu Met Trp Lys Gln Ser Ile Trp Thr Ser 
             100                105                110
Thr Ile Ser Ser His Leu Ala Thr Lys His Leu Lys Glu Gly Gly Leu 
         115                120                125
Leu Thr Leu Ala Gly Ala Lys Ala Ala Leu Asp Gly Thr Pro Gly Met 
     130                135                140
Ile Gly Tyr Gly Met Ala Lys Gly Ala Val His Gln Leu Cys Gln Ser 
 145                150                155                160
Leu Ala Gly Lys Asn Ser Gly Met Pro Ser Gly Ala Ala Ala Ile Ala 
                 165                170                175
Val Leu Pro Val Thr Leu Asp Thr Pro Met Asn Arg Lys Ser Met Pro 
             180                185                190
Glu Ala Asp Phe Ser Ser Trp Thr Pro Leu Glu Phe Leu Val Glu Thr 
         195                200                205
Phe His Asp Trp Ile Thr Gly Asn Lys Arg Pro Asn Ser Gly Ser Leu 
     210                215                220
Ile Gln Val Val Thr Thr Asp Gly Lys Thr Glu Leu Thr Pro Ala Tyr 
 225                230                235                240
Phe 
                 245



<210> 2477
<211> 1394
<212> DNA
<213> Homo sapiens
<308> BC000576
<400> 2477

ggcacgagg  ggagccggg  tggcaggag  aggatggcg  cggcggcgg  tgcaggcga  60
gcgcgccgg  tgctggtgt  cggcggcag  ggcgctctg  gttctcgat  cgtgcaggc  120
tttcgggcc  gcaactggt  ggttgccag  gttgatgtg  tggagaatg  agaggccag  180
gctagcatc  ttgttaaaa  gacagactc  ttcactgag  aggctgacc  ggtgactgc  240
gaggttgga  agctcttgg  tgaagagaa  gtggatgca  ttctttgcg  tgctggagg  300
tgggccggg  gcaatgcca  atccaagtc  ctctttaag  actgtgacc  gatgtggaa  360
cagagcata  ggacatcga  catctccag  catctggct  ccaagcatc  caaggaagg  420
ggcctcctg  ccttggctg  cgcaaaggc  gccctggat  ggactcctg  tatgatcgg  480
tacggcatg  ccaagggtg  tgttcacca  ctctgccag  gcctggctg  gaagaacag  540
ggcatgccg  ccggggcag  cgccatcgc  gtgctcccg  ttaccctgg  taccccgat  600
aacaggaaa  caatgcctg  ggctgactt  agctcctgg  cacccttag  attcctagt  660
gaaactttc  atgactgga  cacagggaa  aaccgaccg  gctcaggaa  cctaatcca  720
gtggtaacc  cagaaggaa  gacggaact  accccagca  atttttagg  ctcatctca  780
tgcctatga  gggcctgcc  gaaaagtca  taacctgtc  cagtgtggc  ttgtccagc  840
ttgtgtttt  tgtaacccc  gtttgtggt  cgagataat  agtcctatt  ttctctcac  900
taatatgca  ttgctctcc  aggacagtg  aatacattt  tgtgaagta  agacatgcg  960
gactggtgg  ctgcaaata  catccgtca  tctgtgtta  ctgcatagg  agggctctg  1020
atagcacct  ctatagcgg  gtcatgttg  atcgctttt  tgactgttc  tctgtcctt  1080
acagtggct  tcatcttga  tactttgtt  atttgttgg  attggggac  ttttaaagg  1140
tgagttatt  ttgaatgtc  tgtttatgt  atagacgta  ttttcgcat  cttgaatta  1200
actgcctta  ctccttttg  ggtataagc  aaactccat  gactctgtc  tggtatcct  1260
ttcctgtgt  gttgccctg  gtcctctgg  ctagggtta  gtgtgcaag  taactactc  1320
tgagtattc  gaatgttgt  cctaataaa  gcacttgtt  tctgtcttc  ttaaaaaaa  1380
aaaaaaaaa  aaaa  1394



<210> 2478
<211> 244
<212> PRT
<213> Homo sapiens
<308> P09417
<400> 2478

Met Ala Ala Ala Ala Ala Ala Gly Glu Ala Arg Arg Val Leu Val Tyr 
  1               5                  10                  15
Gly Gly Arg Gly Ala Leu Gly Ser Arg Cys Val Gln Ala Phe Arg Ala 
             20                  25                  30
Arg Asn Trp Trp Val Ala Ser Val Asp Val Val Glu Asn Glu Glu Ala 
         35                  40                  45
Ser Ala Thr Ile Ile Val Lys Met Thr Asp Ser Phe Thr Glu Gln Ala 
     50                  55                  60
Asp Gln Val Thr Ala Glu Val Gly Lys Leu Leu Gly Glu Glu Lys Val 
 65                  70                  75                  80
Asp Ala Ile Leu Cys Val Ala Gly Gly Trp Ala Gly Gly Asn Ala Lys 
                 85                  90                  95
Ser Lys Ser Leu Phe Lys Asn Cys Asp Leu Met Trp Lys Gln Ser Ile 
             100                105                110
Trp Thr Ser Thr Ile Ser Ser His Leu Ala Thr Lys His Leu Lys Glu 
         115                120                125
Gly Gly Leu Leu Thr Leu Ala Gly Ala Lys Ala Ala Leu Asp Gly Thr 
     130                135                140
Pro Gly Met Ile Gly Tyr Gly Met Ala Lys Gly Ala Val His Gln Leu 
 145                150                155                160
Cys Gln Ser Leu Ala Gly Lys Asn Ser Gly Met Pro Pro Gly Ala Ala 
                 165                170                175
Ala Ile Ala Val Leu Pro Val Thr Leu Asp Thr Pro Met Asn Arg Lys 
             180                185                190
Ser Met Pro Glu Ala Asp Phe Ser Ser Trp Thr Pro Leu Glu Phe Leu 
         195                200                205
Val Glu Thr Phe His Asp Trp Ile Thr Gly Lys Asn Arg Pro Ser Ser 
     210                215                220
Gly Ser Leu Ile Gln Val Val Thr Thr Glu Gly Arg Thr Glu Leu Thr 
 225                230                235                240
Pro Ala Tyr Phe 
                 245



<210> 2479
<211> 1307
<212> DNA
<213> Rattus norvegicus
<308> J03481
<400> 2479

gtgcttttg  gtttggcga  cagttccgc  ggagtcttg  caggagcag  atggcggct  60
cgggcgagg  gcgccgagt  ctggtgtac  gcggcaggg  tgctctggg  tcgcgctgc  120
tacaggcct  ccgggcccg  aactggtgg  ttgccagca  tgatgtggt  gagaatgaa  180
aggccagtg  cagcgtgat  gttaagatg  cagattcat  cacggagca  gctgaccag  240
tcactgctg  ggtcgggaa  ctcctaggt  accagaagg  ggatgccat  ctctgtgtg  300
ctggaggat  ggccggggg  aatgccaaa  ccaagtcac  ctttaaaaa  tgtgacctg  360
tgtggaagc  gagtatttg  acatccacc  tctctagcc  cttggccac  aagcacctg  420
aggaaggag  cctcttgac  ctggccggg  ccaaagctg  gttggatgg  actcctggg  480
tgattggct  cggcatggc  aagggagcc  tccatcagc  ctgccagag  cttgcaggg  540
agaacagtg  catgccgtc  ggggctgcc  ccattgctg  gcttcccgt  accctggat  600
ctccgatga  caggaaatc  atgcccgag  cagacttca  ctcctggac  cccttagag  660
tcctggtgg  gaccttcca  gactggatc  ctgggaaca  acggccaaa  tcaggaagc  720
taatccagg  ggtaaccac  gacgggaag  cagagctta  tccagccta  ttctaagtt  780
cacctcagt  cccaggaga  ccctcttga  actctacta  cctgtgtct  tattgccgc  840
cctggcccc  tgttgtctg  attcctgtt  gtggtacga  ataactagt  ccgtttgtc  900
cttacgtag  gctcctttt  tgtcctggg  tggtgaggt  tgtttatgg  gaatgagtg  960
gggcctgta  gtagcacca  cagtgctga  gcccaggga  gtatgtgtg  aggccgtca  1020
cccagcatc  cagactgct  tggagaccc  tttgatagt  catttttta  catttgggg  1080
actttgaaa  ccaacttgt  tttaaattc  atgttagtg  catagatgt  gtttttgct  1140
cctgaaaat  aactgccat  aaaattcat  ggtgatgta  gtaagcaaa  cctaatgga  1200
tctgttgga  atcatttgt  ttccagcct  ggctaagtg  ttatgagaa  tattcgtga  1260
tgttcggag  gttcttcct  ataaacaca  ttcatgtcc  cgaattc  1307



<210> 2480
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> P11348
<400> 2480

Met Ala Ala Ser Gly Glu Ala Arg Arg Val Leu Val Tyr Gly Gly Arg 
  1               5                  10                  15
Gly Ala Leu Gly Ser Arg Cys Val Gln Ala Phe Arg Ala Arg Asn Trp 
             20                  25                  30
Trp Val Ala Ser Ile Asp Val Val Glu Asn Glu Glu Ala Ser Ala Ser 
         35                  40                  45
Val Ile Val Lys Met Thr Asp Ser Phe Thr Glu Gln Ala Asp Gln Val 
     50                  55                  60
Thr Ala Glu Val Gly Lys Leu Leu Gly Asp Gln Lys Val Asp Ala Ile 
 65                  70                  75                  80
Leu Cys Val Ala Gly Gly Trp Ala Gly Gly Asn Ala Lys Ser Lys Ser 
                 85                  90                  95
Leu Phe Lys Asn Cys Asp Leu Met Trp Lys Gln Ser Ile Trp Thr Ser 
             100                105                110
Thr Ile Ser Ser His Leu Ala Thr Lys His Leu Lys Glu Gly Gly Leu 
         115                120                125
Leu Thr Leu Ala Gly Ala Lys Ala Ala Leu Asp Gly Thr Pro Gly Met 
     130                135                140
Ile Gly Tyr Gly Met Ala Lys Gly Ala Val His Gln Leu Cys Gln Ser 
 145                150                155                160
Leu Ala Gly Lys Asn Ser Gly Met Pro Ser Gly Ala Ala Ala Ile Ala 
                 165                170                175
Val Leu Pro Val Thr Leu Asp Thr Pro Met Asn Arg Lys Ser Met Pro 
             180                185                190
Glu Ala Asp Phe Ser Ser Trp Thr Pro Leu Glu Phe Leu Val Glu Thr 
         195                200                205
Phe His Asp Trp Ile Thr Gly Asn Lys Arg Pro Asn Ser Gly Ser Leu 
     210                215                220
Ile Gln Val Val Thr Thr Asp Gly Lys Thr Glu Leu Thr Pro Ala Tyr 
 225                230                235                240
Phe 
                 245



<210> 2481
<211> 1394
<212> DNA
<213> Homo sapiens
<308> BC000576
<400> 2481

ggcacgagg  ggagccggg  tggcaggag  aggatggcg  cggcggcgg  tgcaggcga  60
gcgcgccgg  tgctggtgt  cggcggcag  ggcgctctg  gttctcgat  cgtgcaggc  120
tttcgggcc  gcaactggt  ggttgccag  gttgatgtg  tggagaatg  agaggccag  180
gctagcatc  ttgttaaaa  gacagactc  ttcactgag  aggctgacc  ggtgactgc  240
gaggttgga  agctcttgg  tgaagagaa  gtggatgca  ttctttgcg  tgctggagg  300
tgggccggg  gcaatgcca  atccaagtc  ctctttaag  actgtgacc  gatgtggaa  360
cagagcata  ggacatcga  catctccag  catctggct  ccaagcatc  caaggaagg  420
ggcctcctg  ccttggctg  cgcaaaggc  gccctggat  ggactcctg  tatgatcgg  480
tacggcatg  ccaagggtg  tgttcacca  ctctgccag  gcctggctg  gaagaacag  540
ggcatgccg  ccggggcag  cgccatcgc  gtgctcccg  ttaccctgg  taccccgat  600
aacaggaaa  caatgcctg  ggctgactt  agctcctgg  cacccttag  attcctagt  660
gaaactttc  atgactgga  cacagggaa  aaccgaccg  gctcaggaa  cctaatcca  720
gtggtaacc  cagaaggaa  gacggaact  accccagca  atttttagg  ctcatctca  780
tgcctatga  gggcctgcc  gaaaagtca  taacctgtc  cagtgtggc  ttgtccagc  840
ttgtgtttt  tgtaacccc  gtttgtggt  cgagataat  agtcctatt  ttctctcac  900
taatatgca  ttgctctcc  aggacagtg  aatacattt  tgtgaagta  agacatgcg  960
gactggtgg  ctgcaaata  catccgtca  tctgtgtta  ctgcatagg  agggctctg  1020
atagcacct  ctatagcgg  gtcatgttg  atcgctttt  tgactgttc  tctgtcctt  1080
acagtggct  tcatcttga  tactttgtt  atttgttgg  attggggac  ttttaaagg  1140
tgagttatt  ttgaatgtc  tgtttatgt  atagacgta  ttttcgcat  cttgaatta  1200
actgcctta  ctccttttg  ggtataagc  aaactccat  gactctgtc  tggtatcct  1260
ttcctgtgt  gttgccctg  gtcctctgg  ctagggtta  gtgtgcaag  taactactc  1320
tgagtattc  gaatgttgt  cctaataaa  gcacttgtt  tctgtcttc  ttaaaaaaa  1380
aaaaaaaaa  aaaa  1394



<210> 2482
<211> 244
<212> PRT
<213> Homo sapiens
<308> P09417
<400> 2482

Met Ala Ala Ala Ala Ala Ala Gly Glu Ala Arg Arg Val Leu Val Tyr 
  1               5                  10                  15
Gly Gly Arg Gly Ala Leu Gly Ser Arg Cys Val Gln Ala Phe Arg Ala 
             20                  25                  30
Arg Asn Trp Trp Val Ala Ser Val Asp Val Val Glu Asn Glu Glu Ala 
         35                  40                  45
Ser Ala Thr Ile Ile Val Lys Met Thr Asp Ser Phe Thr Glu Gln Ala 
     50                  55                  60
Asp Gln Val Thr Ala Glu Val Gly Lys Leu Leu Gly Glu Glu Lys Val 
 65                  70                  75                  80
Asp Ala Ile Leu Cys Val Ala Gly Gly Trp Ala Gly Gly Asn Ala Lys 
                 85                  90                  95
Ser Lys Ser Leu Phe Lys Asn Cys Asp Leu Met Trp Lys Gln Ser Ile 
             100                105                110
Trp Thr Ser Thr Ile Ser Ser His Leu Ala Thr Lys His Leu Lys Glu 
         115                120                125
Gly Gly Leu Leu Thr Leu Ala Gly Ala Lys Ala Ala Leu Asp Gly Thr 
     130                135                140
Pro Gly Met Ile Gly Tyr Gly Met Ala Lys Gly Ala Val His Gln Leu 
 145                150                155                160
Cys Gln Ser Leu Ala Gly Lys Asn Ser Gly Met Pro Pro Gly Ala Ala 
                 165                170                175
Ala Ile Ala Val Leu Pro Val Thr Leu Asp Thr Pro Met Asn Arg Lys 
             180                185                190
Ser Met Pro Glu Ala Asp Phe Ser Ser Trp Thr Pro Leu Glu Phe Leu 
         195                200                205
Val Glu Thr Phe His Asp Trp Ile Thr Gly Lys Asn Arg Pro Ser Ser 
     210                215                220
Gly Ser Leu Ile Gln Val Val Thr Thr Glu Gly Arg Thr Glu Leu Thr 
 225                230                235                240
Pro Ala Tyr Phe 
                 245



<210> 2483
<211> 2415
<212> DNA
<213> Rattus norvegicus
<308> J03572
<400> 2483

cacggcgct  cttagggcc  ccgctcggc  cgccgggac  gaccctccc  actcctgcc  60
gcaggatcg  aacgtcaat  aacggctga  actgccccc  acctcttcc  acccatctg  120
gctccagcg  ggaacggat  tcggggtac  ccatgatct  gccattttt  gtactggcc  180
tcggaccct  ccttaccaa  tcatttgtg  cagagaaag  gaaagaccc  agttactgg  240
gacagcaag  ccaagagac  ttgaaaaat  ccctgaaac  ccaaaaact  aacaccaac  300
tggccaaga  catcatcat  ttcctggga  atggtatgg  cgtctccac  gtgacagct  360
cccgcatcc  taagggcca  ctacaccac  acacgggcg  ggagacacg  ctggagatg  420
acaagttcc  ctttgtggc  ctctccaag  cgtacaaca  caacgctca  gtccccgac  480
gcgcgggca  tgccactgc  tacttgtgt  gcgtgaagg  caacgaggg  accgtggga  540
tgagcgcgg  cactgagcg  acgcgatgc  acaccactc  ggggaacga  gtcacgtcc  600
tcctgcgct  ggccaagga  gctgggaag  ccgtgggca  cgtgaccac  actcgggtg  660
accacgcca  tcccagtgc  gcctatgcg  actcggccg  tcgggactg  tactcggac  720
atgagatgc  cccagaggc  ctgagccag  gctgcaagg  catcgccta  cagctaatg  780
acaacatca  ggacatcga  gtgatcatg  gtggtggcc  gaagtacat  taccccaag  840
acagaactg  tgtggaata  gaactggat  agaaggcca  gggcaccag  ctggatggc  900
tggacctca  cagcatttg  aagagcttc  aacctagac  caagcactc  cactatgtc  960
ggaaccgca  tgaactgct  gcccttgac  cctccaggg  ggactacct  ttaggtctc  1020
ttgagcccg  ggacatgca  tatgagttg  atcggaaca  cctgactga  ccttccctc  1080
cggagatgg  ggaggtggc  ctccggatc  tgacaaaga  tcccaaagg  ttcttcttg  1140
tagtggaag  aggcaggat  gaccacggg  accatgaag  caaggccaa  caggcgctg  1200
atgaggccg  ggagatgga  gaggccatc  gaaaggcgg  caccatgac  tcccagaaa  1260
acacgttga  tgtggttac  gctgatcac  cccacgttt  cacgtttgg  ggctacacc  1320
ccaggggca  ctccatttt  ggtctggct  ccatggtga  cgacacgga  aagaagccc  1380
tcacagcca  cctgtatgg  aacgggcct  gttacaagg  ggtggacgg  gaacgggag  1440
acgtctcca  ggtggatta  gctcacaac  actaccagg  ccagtccgc  gtccccctg  1500
ggcacgaga  ccacggtgg  gaagatgtg  cggtctttg  caagggccc  atggctcac  1560
tgcttcacg  cgtccatga  cagaactac  tcccccacg  catggcgta  gcctcctgc  1620
ttggagcca  ccttgacca  tgtgcctgg  ccagctctg  gagcagccc  tccccaggg  1680
ccctgctgc  tccactggc  ctgttcccc  tacgcaccc  gttctgagg  cccaggtcc  1740
acaagagcc  acaatggac  gccggctcc  ctccctttg  ggcctgcca  ctggccgcc  1800
acactcaac  gggaggccc  ggcaacctc  agcaggaac  gaagtttgc  acctgcctc  1860
cttccgccc  gaaccctcc  tgggtcgga  tcctggctc  gccgttgtt  ctctattca  1920
tgccttttg  ccagcaggg  gggtttctc  cttgggccg  caggacaca  actgcgcag  1980
ttcccaaag  accttattt  tctaccaaa  atactctcc  gaccctgca  ccatcatgg  2040
acattccag  tctgacctt  tctccccta  cccttctct  tggaacact  ggtcccata  2100
tcacagcca  tccctcaac  caaccctcc  tggagggaa  accaggtct  ctcagggtg  2160
gactcccag  aagccacct  cggggttgg  tgtctaccc  gggtggcca  gctgggaag  2220
acaacccag  cggacagga  gcacacact  cccacccag  tccagagac  cgccaaccc  2280
tcactgaag  gactcccct  tttggaata  caaaaaaaa  aagaaagaa  aaaaagaaa  2340
aaattttaa  ttctctttt  ggtgttggt  aaaagggaa  acaagacat  taaataaaa  2400
gttccaaat  aaaaa  2415



<210> 2484
<211> 524
<212> PRT
<213> Rattus norvegicus
<308> P08289
<400> 2484

Met Ile Leu Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
  1               5                  10                  15
Ser Phe Val Pro Glu Lys Glu Lys Asp Pro Ser Tyr Trp Arg Gln Gln 
             20                  25                  30
Ala Gln Glu Thr Leu Lys Asn Ala Leu Lys Leu Gln Lys Leu Asn Thr 
         35                  40                  45
Asn Val Ala Lys Asn Ile Ile Met Phe Leu Gly Asp Gly Met Gly Val 
     50                  55                  60
Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
 65                  70                  75                  80
Thr Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                 85                  90                  95
Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
             100                105                110
Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
         115                120                125
Gly Val Ser Ala Ala Thr Glu Arg Thr Arg Cys Asn Thr Thr Gln Gly 
     130                135                140
Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
 145                150                155                160
Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                 165                170                175
Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
             180                185                190
Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
         195                200                205
Met His Asn Ile Lys Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
     210                215                220
Tyr Met Tyr Pro Lys Asn Arg Thr Asp Val Glu Tyr Glu Leu Asp Glu 
 225                230                235                240
Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Ile Ser Ile Trp 
                 245                250                255
Lys Ser Phe Lys Pro Arg His Lys His Ser His Tyr Val Trp Asn Arg 
             260                265                270
Thr Glu Leu Leu Ala Leu Asp Pro Ser Arg Val Asp Tyr Leu Leu Gly 
         275                280                285
Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Leu 
     290                295                300
Thr Asp Pro Ser Leu Ser Glu Met Val Glu Val Ala Leu Arg Ile Leu 
 305                310                315                320
Thr Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                 325                330                335
Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
             340                345                350
Val Glu Met Asp Glu Ala Ile Gly Lys Ala Gly Thr Met Thr Ser Gln 
         355                360                365
Lys Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
     370                375                380
Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
 385                390                395                400
Met Val Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                 405                410                415
Asn Gly Pro Gly Tyr Lys Val Val Asp Gly Glu Arg Glu Asn Val Ser 
             420                425                430
Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
         435                440                445
Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Lys 
     450                455                460
Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Ile 
 465                470                475                480
Pro His Val Met Ala Tyr Ala Ser Cys Ile Gly Ala Asn Leu Asp His 
                 485                490                495
Cys Ala Trp Ala Ser Ser Ala Ser Ser Pro Ser Pro Gly Ala Leu Leu 
             500                505                510
Leu Pro Leu Ala Leu Phe Pro Leu Arg Thr Leu Phe 
         515                520



<210> 2485
<211> 2590
<212> DNA
<213> Homo sapiens
<308> XM_001826
<400> 2485

agaaactcc  ggtgtggca  ctgagatgg  ccaggaaag  actatatta  cttcaaaaa  60
agaggtaca  gcgatgttt  aggtggcat  aagctcagt  gtgttatat  ggaatgagt  120
agtgaccat  ctggagcct  cctgaaaga  gattggaac  tcagttaac  tctgaccac  180
gccagccca  cccctccca  ccacgtcga  tgcatctct  ggctccagg  ataaagcag  240
tcttggggt  caccatgat  tcaccattc  tagtactgg  cattggcac  tgccttact  300
actccttag  gccagagaa  gagaaagac  ccaagtact  gcgagacca  gcgcaagag  360
cactgaaat  tgccctgga  cttcagaag  tcaacacca  cgtggctaa  aatgtcatc  420
tgttcctgg  agatgggat  ggtgtctcc  cagtgacgg  tgcccgcat  ctcaagggt  480
agctccacc  caaccctgg  gaggagacc  ggctggaga  ggacaagtt  cccttcgtg  540
ccctctcca  gacgtacaa  accaatgcc  aggtccctg  cagtgccgg  accgccacc  600
cctacctgt  tggggtgaa  gccaatgag  gcaccgtgg  ggtaagcgc  gccactgag  660
gttcccggt  caacaccac  caggggaac  aggtcacct  catcctgcg  tgggccaag  720
acgctggga  atctgtggg  attgtgacc  ccacgagag  gaaccatgc  acccccagc  780
ccgcctacg  ccactcggc  gaccgggac  ggtactcag  caacgagat  ccccctgag  840
ccttgagcc  gggctgtaa  gacatcgcc  accagctca  gcataacat  agggacatt  900
acgtgatca  ggggggtgg  cggaaatac  tgtacccca  gaataaaac  gatgtggag  960
atgagagtg  cgagaaagc  aggggcacg  ggctggacg  cctggacct  gttgacacc  1020
ggaagagct  caaaccgag  tacaagcac  cccacttca  ctggaaccg  acggaactc  1080
tgacccttg  cccccacaa  gtggactac  tattgggtc  cttcgagcc  ggggacatg  1140
agtacgagc  gaacaggaa  aacgtgacg  acccgtcac  ctccgagat  gtggtggtg  1200
ccatccaga  cctgcggaa  aaccccaaa  gcttcttct  gctggtgga  ggaggcaga  1260
ttgaccacg  gcaccatga  ggaaaagcc  agcaggccc  gcatgaggc  gtggagatg  1320
accgggcca  cgggcaggc  ggcagcttg  cctcctcgg  agacactct  accgtggtc  1380
ctgcggacc  ttcccacgt  ttcacattt  gtggataca  cccccgtgg  aactctatc  1440
ttggtctgg  ccccatgct  agtgacaca  acaagaagc  cttcactgc  atcctgtat  1500
gcaatgggc  tggctacaa  gtggtgggc  gtgaacgag  gaatgtctc  atggtggac  1560
atgctcaca  caactacca  gcgcagtct  ctgtgcccc  gcgccacga  acccacggc  1620
gggaggacg  ggccgtctt  tccaagggc  ccatggcgc  cctgctgca  ggcgtccac  1680
agcagaact  cgtccccca  gtgatggcg  atgcagcct  catcggggc  aacctcggc  1740
actgtgctc  tgccagctc  gcaggcagc  ttgctgcag  ccccctgct  ctcgcgctg  1800
ccctctacc  cctgagcgt  ctgttctga  ggcccaggg  ccgggcacc  acaagcccg  1860
gacagatgc  aacttccca  acggcagcc  ccccctcaa  gggcaggga  gtgggggcc  1920
cctcagcct  tgcaactgc  agaaagggg  cccaagaaa  caaagtctg  cgcccacct  1980
gctcccctc  ggaatcttc  ccaagggcc  aacccactt  tggcctcca  cctttgctc  2040
ctccccgct  ccctttggc  aacagggta  atttctctt  ggcaggcag  gagtacaga  2100
tgcagacat  ctcaaagcc  cttattttt  tagcgaacg  atttctcca  acccagagg  2160
cctgaagcc  ccgtggaac  ttctggatc  gaccctccc  gtctcatct  ctgaccctc  2220
cactcccat  tccttacct  tggaacccc  caggcccta  aatgctcat  tccctgtcc  2280
caggcccag  cctccttca  gggagttga  gtctttctc  tcaggacaa  gccttgctc  2340
ctcactcac  ccaagacca  cagggtccc  ggaagccgg  gcctgggtg  ccatcctac  2400
cagcgtggc  caggccggg  agagccacc  ggcagggct  acactcctg  gctctgaac  2460
cacacgcca  ctcctctct  aagcgactc  cctgtttgg  acggcaaaa  aaaattttt  2520
tttctcttt  tggtggtgg  taaaaggga  cacaaaaca  ttaaataaa  ctttccaaa  2580
atttccgagg  2590



<210> 2486
<211> 524
<212> PRT
<213> Homo sapiens
<308> XP_001826
<400> 2486

Met Ile Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
  1               5                  10                  15
Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
             20                  25                  30
Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr 
         35                  40                  45
Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
     50                  55                  60
Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
 65                  70                  75                  80
Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                 85                  90                  95
Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
             100                105                110
Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
         115                120                125
Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly 
     130                135                140
Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
 145                150                155                160
Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                 165                170                175
Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
             180                185                190
Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
         195                200                205
Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
     210                215                220
Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu 
 225                230                235                240
Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp 
                 245                250                255
Lys Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg 
             260                265                270
Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly 
         275                280                285
Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val 
     290                295                300
Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu 
 305                310                315                320
Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                 325                330                335
Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
             340                345                350
Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser 
         355                360                365
Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
     370                375                380
Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
 385                390                395                400
Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                 405                410                415
Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
             420                425                430
Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
         435                440                445
Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys 
     450                455                460
Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val 
 465                470                475                480
Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His 
                 485                490                495
Cys Ala Pro Ala Ser Ser Ala Gly Ser Leu Ala Ala Gly Pro Leu Leu 
             500                505                510
Leu Ala Leu Ala Leu Tyr Pro Leu Ser Val Leu Phe 
         515                520



<210> 2487
<211> 924
<212> DNA
<213> Rattus norvegicus
<308> J03588
<400> 2487

cctggtggt  ccgcagccg  actctcctg  cctggtgtg  acagcctca  catgagttc  60
tctgcagcc  gcccgcttt  cgcgcctgg  gaggactgc  gccccgcgt  gcgcgcggc  120
cccgcggcc  atgatacgt  tgacacgca  ctgcagatc  tgggcaagc  agtaatgga  180
cgttgggag  ccccctaca  gcattcgct  gcggctgct  ctgcctcca  agggggccg  240
gtcctggaa  tgggctttg  gatggccat  gcagcctcc  gggtgcagc  ggcccccat  300
aaggaacac  ggattattg  atgcaacga  ggggtcttc  agcgtctac  aaactgggc  360
ctgaagcag  cacataagg  tgttccctt  aaaggcctg  gggaggagg  ggcacctac  420
ctgcctgat  gtcactttg  tgggattct  tacgacaca  atccactgt  tgaagagac  480
tggcacact  accagttca  ctttattaa  actcatgct  tccgtttgc  gaagcctgg  540
ggtatcctc  cttactgca  cctcacgtc  tggggggaa  tcatgaagt  caagtacac  600
gacatcact  ccatgtttg  ggagactca  gtgcctgca  tgctggaag  tggcttcca  660
agagaaaac  tctgtacag  ggtgatggc  ctggtgccc  cagccgact  ccgctacta  720
gccttccct  agatgatca  acccctggt  accaagcac  gagcggctg  cccagggct  780
caaggagaa  atgtcctcc  cagtgcctt  gtagctgga  tgtggctcc  gcctctcca  840
tatccctgc  gtgtgacat  ctaacctct  cctggtacg  ccatctccc  agagctcag  900
agtaaaata  atgctacca  gact  924



<210> 2488
<211> 235
<212> PRT
<213> Rattus norvegicus
<308> P10868
<400> 2488

Ser Ser Ser Ala Ala Ser Pro Leu Phe Ala Pro Gly Glu Asp Cys Gly 
  1               5                  10                  15
Pro Ala Trp Arg Ala Ala Pro Ala Ala Tyr Asp Thr Ser Asp Thr His 
             20                  25                  30
Leu Gln Ile Leu Gly Lys Pro Val Met Glu Arg Trp Glu Thr Pro Tyr 
         35                  40                  45
Met His Ser Leu Ala Ala Ala Ala Ala Ser Arg Gly Gly Arg Val Leu 
     50                  55                  60
Glu Val Gly Phe Gly Met Ala Ile Ala Ala Ser Arg Val Gln Gln Ala 
 65                  70                  75                  80
Pro Ile Lys Glu His Trp Ile Ile Glu Cys Asn Asp Gly Val Phe Gln 
                 85                  90                  95
Arg Leu Gln Asn Trp Ala Leu Lys Gln Pro His Lys Val Val Pro Leu 
             100                105                110
Lys Gly Leu Trp Glu Glu Glu Ala Pro Thr Leu Pro Asp Gly His Phe 
         115                120                125
Asp Gly Ile Leu Tyr Asp Thr Tyr Pro Leu Ser Glu Glu Thr Trp His 
     130                135                140
Thr His Gln Phe Asn Phe Ile Lys Thr His Ala Phe Arg Leu Leu Lys 
 145                150                155                160
Pro Gly Gly Ile Leu Thr Tyr Cys Asn Leu Thr Ser Trp Gly Glu Leu 
                 165                170                175
Met Lys Ser Lys Tyr Thr Asp Ile Thr Ala Met Phe Glu Glu Thr Gln 
             180                185                190
Val Pro Ala Leu Leu Glu Ala Gly Phe Gln Arg Glu Asn Ile Cys Thr 
         195                200                205
Glu Val Met Ala Leu Val Pro Pro Ala Asp Cys Arg Tyr Tyr Ala Phe 
     210                215                220
Pro Gln Met Ile Thr Pro Leu Val Thr Lys His 
 225                230                235



<210> 2489
<211> 993
<212> DNA
<213> Homo sapiens
<308> Z49878
<400> 2489

cggcggcgc  cgatcgagg  cgggtcgcc  tccagcctg  agcatgagc  cccccagcg  60
gacccccat  ttcgcgccc  gcgagaact  cagccccgc  tggggggcg  cgcccgcgg  120
ctacgacgc  gcggacacg  acctgcgca  cctgggcaa  ccggtgatg  agcgctggg  180
gacccccta  atgcacgcg  tggccgccg  cgcctcctc  aaagggggc  gggtcctgg  240
ggtgggctt  ggcatggcc  tcgcagcgt  aaaggtgca  gaggcgccc  ttgatgagc  300
ttggatcat  gagtgcaat  acggcgtct  ccagcggct  cgggactgg  ccccacggc  360
gacacacaa  gtcatcccc  tgaaaggcc  gtgggagga  gtggcaccc  ccctgcctg  420
cggtcactt  gatgggatc  tgtacgaca  gtacccact  tcggaggag  cctggcaca  480
acaccagtt  aacttcatc  agaaccacg  ctttcgcct  ctgaagccg  ggggcgtcc  540
cacctactg  aacctcacc  cctgggggg  gctgatgaa  tccaagtac  cagacatca  600
catcatgtt  gaggagacg  aggtgcccg  gctgctgga  gccggcttc  ggagggaga  660
catccgtac  gaggtgatg  cgctggtcc  accggccga  tgccgctac  acgccttcc  720
acagatgat  acgcccctg  tgaccaaag  ctgagcccc  accccggcc  ggccacacc  780
atgccctcc  ccgtgcctt  ctggccggg  gtccagggt  tcgcaccag  cctgggctg  840
tcccagctg  gtgtcacca  aagctttcc  ggcttctct  tgaggggtc  caccagccc  900
gggctgatc  cagctgtgt  tcaccagca  ctttcccag  ttgctctgt  agggtcact  960
ctgcccact  cagggtgcc  tgaggtgaa  ccg  993



<210> 2490
<211> 236
<212> PRT
<213> Homo sapiens
<308> Q14353
<400> 2490

Met Ser Ala Pro Ser Ala Thr Pro Ile Phe Ala Pro Gly Glu Asn Cys 
  1               5                  10                  15
Ser Pro Ala Trp Gly Ala Ala Pro Ala Ala Tyr Asp Ala Ala Asp Thr 
             20                  25                  30
His Leu Arg Ile Leu Gly Lys Pro Val Met Glu Arg Trp Glu Thr Pro 
         35                  40                  45
Tyr Met His Ala Leu Ala Ala Ala Ala Ser Ser Lys Gly Gly Arg Val 
     50                  55                  60
Leu Glu Val Gly Phe Gly Met Ala Ile Ala Ala Ser Lys Val Gln Glu 
 65                  70                  75                  80
Ala Pro Ile Asp Glu His Trp Ile Ile Glu Cys Asn Asp Gly Val Phe 
                 85                  90                  95
Gln Arg Leu Arg Asp Trp Ala Pro Arg Gln Thr His Lys Val Ile Pro 
             100                105                110
Leu Lys Gly Leu Trp Glu Asp Val Ala Pro Thr Leu Pro Asp Gly His 
         115                120                125
Phe Asp Gly Ile Leu Tyr Asp Thr Tyr Pro Leu Ser Glu Glu Thr Trp 
     130                135                140
His Thr His Gln Phe Asn Phe Ile Lys Asn His Ala Phe Arg Leu Leu 
 145                150                155                160
Lys Pro Gly Gly Val Leu Thr Tyr Cys Asn Leu Thr Ser Trp Gly Glu 
                 165                170                175
Leu Met Lys Ser Lys Tyr Ser Asp Ile Thr Ile Met Phe Glu Glu Thr 
             180                185                190
Gln Val Pro Ala Leu Leu Glu Ala Gly Phe Arg Arg Glu Asn Ile Arg 
         195                200                205
Thr Glu Val Met Ala Leu Val Pro Pro Ala Asp Cys Arg Tyr Tyr Ala 
     210                215                220
Phe Pro Gln Met Ile Thr Pro Leu Val Thr Lys Gly 
 225                230                235



<210> 2491
<211> 1684
<212> DNA
<213> Rattus norvegicus
<308> J03621
<400> 2491

gctcctact  ggcctgact  tgctggtga  ctccctgca  gctttggtg  gctttgagt  60
tggcaacct  aattctatg  ggatttgta  ctttagaac  gctgtatgt  acgctcatc  120
tggtgaggt  tgtgcctca  ttttaacct  taaagatgg  aaatttgta  atggaaacc  180
gagctgtgc  gagtgctcc  ggaggactg  tgagcatgg  agtctgata  tatcaacaa  240
ctgttgctc  gccacctct  tctgcaata  agtacgtcc  tgatactta  ttgtatgga  300
ggattttag  gctctttac  gagtcttga  actggagca  gccagaaag  attatctac  360
gaccgtgtc  ggagaacgc  ctaagattt  tacatcatg  tttctgact  cgtgtacat  420
atatcatat  atcttcagt  atctgtaat  aattgaagg  cttacaaat  ttgcggctg  480
cactgcaac  atggtctcc  gcagcagcg  ccttgccgc  gcccgcctg  tgtcgcgca  540
cttcctcct  caacagaat  gaatacggc  cgggtctta  acagcctct  ggaaaaata  600
ctatattga  aaaaatacg  aggttattt  ccagggttt  acaggcaag  agggtacct  660
tcacagcca  caggctttg  agtacggca  caaactcgt  ggaggaacc  ctccaggga  720
agggggcaa  aagcacctg  gcttacctg  ctttaatac  gtgaaggaa  ccaaagaga  780
aacaggagc  acagcttct  tcatttatg  ccctcctcc  ttcgctgct  ccgccatca  840
tgaagcaat  gacgcagag  ttcccttgg  tgtgtgcat  actgaaggt  ttccgcagc  900
ggacatgtt  cgggtcaag  acaagctga  acgccaggg  aagacgagg  taattgggc  960
aaactgccc  ggtatcatc  accctggag  atgcaaaat  ggcatcatg  ctggccaca  1020
tcacaagaa  ggaagaata  gtatcgtgt  caggtccgg  actctgact  atgaagcag  1080
tcaccaaac  acccaagtt  gattggggc  gtccttgtg  attggcatt  gaggtgacc  1140
ttttaatgg  actaatttt  ttgattgcc  tgacgtctt  ctgaaggat  cagctacag  1200
aggcatcgt  ctgattggt  aaattggtg  tcacgctga  gaaaatgcc  cggagtttc  1260
gaaggagca  aactcaggt  caaaggcca  gcctgtagt  tccttcatt  ctggtataa  1320
tgctcctcc  ggcagaagg  tgggccacg  aggggcgat  attgctgga  gaaaaggtg  1380
cgccaaaga  aagatctct  ctcttcaga  tgcgggtgt  attgtcagc  tgtcccccg  1440
acagctggg  acctgcatg  ataaggaat  tgaaaagag  aagatgctt  gaaggacac  1500
acatgaatt  taaggctgt  gaggaaatc  cacagactg  agagcccgt  cagactgca  1560
cccaggcac  tgaccctgg  ctctcagta  aggggaagt  caggcatgt  ttagaatgt  1620
ctaaattga  ctattttca  ttactgtgt  acagagaca  ataataaat  tatcatttg  1680
tttg  1684



<210> 2492
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> P13086
<400> 2492

Met Val Ser Gly Ser Ser Gly Leu Ala Ala Ala Arg Leu Leu Ser Arg 
  1               5                  10                  15
Thr Phe Leu Leu Gln Gln Asn Gly Ile Arg His Gly Ser Tyr Thr Ala 
             20                  25                  30
Ser Arg Lys Asn Ile Tyr Ile Asp Lys Asn Thr Lys Val Ile Cys Gln 
         35                  40                  45
Gly Phe Thr Gly Lys Gln Gly Thr Phe His Ser Gln Gln Ala Leu Glu 
     50                  55                  60
Tyr Gly Thr Lys Leu Val Gly Gly Thr Thr Pro Gly Lys Gly Gly Lys 
 65                  70                  75                  80
Lys His Leu Gly Leu Pro Val Phe Asn Thr Val Lys Glu Ala Lys Glu 
                 85                  90                  95
Lys Thr Gly Ala Thr Ala Ser Val Ile Tyr Val Pro Pro Pro Phe Ala 
             100                105                110
Ala Ala Ala Ile Asn Glu Ala Ile Asp Ala Glu Ile Pro Leu Val Val 
         115                120                125
Cys Ile Thr Glu Gly Ile Pro Gln Gln Asp Met Leu Arg Val Lys His 
     130                135                140
Lys Leu Thr Arg Gln Gly Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro 
 145                150                155                160
Gly Ile Ile Asn Pro Gly Glu Cys Lys Ile Gly Ile Met Pro Gly His 
                 165                170                175
Ile His Lys Lys Gly Arg Ile Gly Ile Val Ser Arg Ser Gly Thr Leu 
             180                185                190
Thr Tyr Glu Ala Val His Gln Thr Thr Gln Val Gly Leu Gly Gln Ser 
         195                200                205
Leu Cys Ile Gly Ile Gly Gly Asp Pro Phe Asn Gly Thr Asn Phe Ile 
     210                215                220
Asp Cys Leu Asp Val Phe Leu Lys Asp Pro Ala Thr Glu Gly Ile Val 
 225                230                235                240
Leu Ile Gly Glu Ile Gly Gly His Ala Glu Glu Asn Ala Ala Glu Phe 
                 245                250                255
Leu Lys Glu His Asn Ser Gly Pro Lys Ala Lys Pro Val Val Ser Phe 
             260                265                270
Ile Ala Gly Ile Thr Ala Pro Pro Gly Arg Arg Met Gly His Ala Gly 
         275                280                285
Ala Ile Ile Ala Gly Gly Lys Gly Gly Ala Lys Glu Lys Ile Ser Ala 
     290                295                300
Leu Gln Ser Ala Gly Val Ile Val Ser Met Ser Pro Ala Gln Leu Gly 
 305                310                315                320
Thr Cys Met Tyr Lys Glu Phe Glu Lys Arg Lys Met Leu 
                 325                330



<210> 2493
<211> 336
<212> DNA
<213> Homo sapiens
<308> BM723664
<400> 2493

ggaaaaggt  gcgccaaag  gaagatctc  gctcttcag  gtgcgggtg  aattgtcag  60
atgtccccc  cacagctgg  aacctgcat  tataaggaa  ttgaaaaga  gaagatgct  120
tgaaggaca  gacatgaat  ttaaggctg  ggaggaaat  tcacagact  gagagcccg  180
ccagactgc  gcccaggca  ctgaccctg  tctctcagt  caggggaag  ccaggcacg  240
tttagaatg  cctaaattg  gctattttc  cttactgtg  aacagagac  gataataaa  300
ctatcattt  atttgaaaa  aaaaaaaaa  aaagac  336



<210> 2494
<211> 333
<212> PRT
<213> Homo sapiens
<308> AAD17940
<400> 2494

Met Val Ser Gly Ser Ser Gly Leu Ala Ala Ala Arg Leu Leu Ser Arg 
  1               5                  10                  15
Ser Phe Leu Leu Pro Gln Asn Gly Ile Arg His Cys Ser Tyr Thr Ala 
             20                  25                  30
Ser Arg Gln His Leu Tyr Val Asp Lys Asn Thr Lys Ile Ile Cys Gln 
         35                  40                  45
Gly Phe Thr Gly Lys Gln Gly Thr Phe His Ser Gln Gln Ala Leu Glu 
     50                  55                  60
Tyr Gly Thr Lys Leu Val Gly Gly Thr Thr Pro Gly Lys Gly Gly Gln 
 65                  70                  75                  80
Thr His Leu Gly Leu Pro Val Phe Asn Thr Val Lys Glu Ala Lys Glu 
                 85                  90                  95
Gln Thr Gly Ala Thr Ala Ser Val Ile Tyr Val Pro Pro Pro Phe Ala 
             100                105                110
Ala Ala Ala Ile Asn Glu Ala Ile Glu Ala Glu Ile Pro Leu Val Val 
         115                120                125
Cys Ile Thr Glu Gly Ile Pro Gln Gln Asp Met Val Arg Val Lys His 
     130                135                140
Lys Leu Leu Arg Gln Glu Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro 
 145                150                155                160
Gly Val Ile Asn Pro Gly Glu Cys Lys Ile Gly Ile Met Pro Gly His 
                 165                170                175
Ile His Lys Lys Gly Arg Ile Gly Ile Val Ser Arg Ser Gly Thr Leu 
             180                185                190
Thr Tyr Glu Ala Val His Gln Thr Thr Gln Val Gly Leu Gly Gln Ser 
         195                200                205
Leu Cys Val Gly Ile Gly Gly Asp Pro Phe Asn Gly Thr Asp Phe Ile 
     210                215                220
Asp Cys Leu Glu Ile Phe Leu Asn Asp Ser Ala Thr Glu Gly Ile Ile 
 225                230                235                240
Leu Ile Gly Glu Ile Gly Gly Asn Ala Glu Glu Asn Ala Ala Glu Phe 
                 245                250                255
Leu Lys Gln His Asn Ser Gly Pro Asn Ser Lys Pro Val Val Ser Phe 
             260                265                270
Ile Ala Gly Leu Thr Ala Pro Pro Gly Arg Arg Met Gly His Ala Gly 
         275                280                285
Ala Ile Ile Ala Gly Gly Lys Gly Gly Ala Lys Glu Lys Ile Ser Ala 
     290                295                300
Leu Gln Ser Ala Gly Val Val Val Ser Met Ser Pro Ala Gln Leu Gly 
 305                310                315                320
Thr Thr Ile Tyr Lys Glu Phe Glu Lys Arg Lys Met Leu 
                 325                330



<210> 2495
<211> 1684
<212> DNA
<213> Rattus norvegicus
<308> J03621
<400> 2495

gctcctact  ggcctgact  tgctggtga  ctccctgca  gctttggtg  gctttgagt  60
tggcaacct  aattctatg  ggatttgta  ctttagaac  gctgtatgt  acgctcatc  120
tggtgaggt  tgtgcctca  ttttaacct  taaagatgg  aaatttgta  atggaaacc  180
gagctgtgc  gagtgctcc  ggaggactg  tgagcatgg  agtctgata  tatcaacaa  240
ctgttgctc  gccacctct  tctgcaata  agtacgtcc  tgatactta  ttgtatgga  300
ggattttag  gctctttac  gagtcttga  actggagca  gccagaaag  attatctac  360
gaccgtgtc  ggagaacgc  ctaagattt  tacatcatg  tttctgact  cgtgtacat  420
atatcatat  atcttcagt  atctgtaat  aattgaagg  cttacaaat  ttgcggctg  480
cactgcaac  atggtctcc  gcagcagcg  ccttgccgc  gcccgcctg  tgtcgcgca  540
cttcctcct  caacagaat  gaatacggc  cgggtctta  acagcctct  ggaaaaata  600
ctatattga  aaaaatacg  aggttattt  ccagggttt  acaggcaag  agggtacct  660
tcacagcca  caggctttg  agtacggca  caaactcgt  ggaggaacc  ctccaggga  720
agggggcaa  aagcacctg  gcttacctg  ctttaatac  gtgaaggaa  ccaaagaga  780
aacaggagc  acagcttct  tcatttatg  ccctcctcc  ttcgctgct  ccgccatca  840
tgaagcaat  gacgcagag  ttcccttgg  tgtgtgcat  actgaaggt  ttccgcagc  900
ggacatgtt  cgggtcaag  acaagctga  acgccaggg  aagacgagg  taattgggc  960
aaactgccc  ggtatcatc  accctggag  atgcaaaat  ggcatcatg  ctggccaca  1020
tcacaagaa  ggaagaata  gtatcgtgt  caggtccgg  actctgact  atgaagcag  1080
tcaccaaac  acccaagtt  gattggggc  gtccttgtg  attggcatt  gaggtgacc  1140
ttttaatgg  actaatttt  ttgattgcc  tgacgtctt  ctgaaggat  cagctacag  1200
aggcatcgt  ctgattggt  aaattggtg  tcacgctga  gaaaatgcc  cggagtttc  1260
gaaggagca  aactcaggt  caaaggcca  gcctgtagt  tccttcatt  ctggtataa  1320
tgctcctcc  ggcagaagg  tgggccacg  aggggcgat  attgctgga  gaaaaggtg  1380
cgccaaaga  aagatctct  ctcttcaga  tgcgggtgt  attgtcagc  tgtcccccg  1440
acagctggg  acctgcatg  ataaggaat  tgaaaagag  aagatgctt  gaaggacac  1500
acatgaatt  taaggctgt  gaggaaatc  cacagactg  agagcccgt  cagactgca  1560
cccaggcac  tgaccctgg  ctctcagta  aggggaagt  caggcatgt  ttagaatgt  1620
ctaaattga  ctattttca  ttactgtgt  acagagaca  ataataaat  tatcatttg  1680
tttg  1684



<210> 2496
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> P13086
<400> 2496

Met Val Ser Gly Ser Ser Gly Leu Ala Ala Ala Arg Leu Leu Ser Arg 
  1               5                  10                  15
Thr Phe Leu Leu Gln Gln Asn Gly Ile Arg His Gly Ser Tyr Thr Ala 
             20                  25                  30
Ser Arg Lys Asn Ile Tyr Ile Asp Lys Asn Thr Lys Val Ile Cys Gln 
         35                  40                  45
Gly Phe Thr Gly Lys Gln Gly Thr Phe His Ser Gln Gln Ala Leu Glu 
     50                  55                  60
Tyr Gly Thr Lys Leu Val Gly Gly Thr Thr Pro Gly Lys Gly Gly Lys 
 65                  70                  75                  80
Lys His Leu Gly Leu Pro Val Phe Asn Thr Val Lys Glu Ala Lys Glu 
                 85                  90                  95
Lys Thr Gly Ala Thr Ala Ser Val Ile Tyr Val Pro Pro Pro Phe Ala 
             100                105                110
Ala Ala Ala Ile Asn Glu Ala Ile Asp Ala Glu Ile Pro Leu Val Val 
         115                120                125
Cys Ile Thr Glu Gly Ile Pro Gln Gln Asp Met Leu Arg Val Lys His 
     130                135                140
Lys Leu Thr Arg Gln Gly Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro 
 145                150                155                160
Gly Ile Ile Asn Pro Gly Glu Cys Lys Ile Gly Ile Met Pro Gly His 
                 165                170                175
Ile His Lys Lys Gly Arg Ile Gly Ile Val Ser Arg Ser Gly Thr Leu 
             180                185                190
Thr Tyr Glu Ala Val His Gln Thr Thr Gln Val Gly Leu Gly Gln Ser 
         195                200                205
Leu Cys Ile Gly Ile Gly Gly Asp Pro Phe Asn Gly Thr Asn Phe Ile 
     210                215                220
Asp Cys Leu Asp Val Phe Leu Lys Asp Pro Ala Thr Glu Gly Ile Val 
 225                230                235                240
Leu Ile Gly Glu Ile Gly Gly His Ala Glu Glu Asn Ala Ala Glu Phe 
                 245                250                255
Leu Lys Glu His Asn Ser Gly Pro Lys Ala Lys Pro Val Val Ser Phe 
             260                265                270
Ile Ala Gly Ile Thr Ala Pro Pro Gly Arg Arg Met Gly His Ala Gly 
         275                280                285
Ala Ile Ile Ala Gly Gly Lys Gly Gly Ala Lys Glu Lys Ile Ser Ala 
     290                295                300
Leu Gln Ser Ala Gly Val Ile Val Ser Met Ser Pro Ala Gln Leu Gly 
 305                310                315                320
Thr Cys Met Tyr Lys Glu Phe Glu Lys Arg Lys Met Leu 
                 325                330



<210> 2497
<211> 336
<212> DNA
<213> Homo sapiens
<308> BM723664
<400> 2497

ggaaaaggt  gcgccaaag  gaagatctc  gctcttcag  gtgcgggtg  aattgtcag  60
atgtccccc  cacagctgg  aacctgcat  tataaggaa  ttgaaaaga  gaagatgct  120
tgaaggaca  gacatgaat  ttaaggctg  ggaggaaat  tcacagact  gagagcccg  180
ccagactgc  gcccaggca  ctgaccctg  tctctcagt  caggggaag  ccaggcacg  240
tttagaatg  cctaaattg  gctattttc  cttactgtg  aacagagac  gataataaa  300
ctatcattt  atttgaaaa  aaaaaaaaa  aaagac  336



<210> 2498
<211> 333
<212> PRT
<213> Homo sapiens
<308> AAD17940
<400> 2498

Met Val Ser Gly Ser Ser Gly Leu Ala Ala Ala Arg Leu Leu Ser Arg 
  1               5                  10                  15
Ser Phe Leu Leu Pro Gln Asn Gly Ile Arg His Cys Ser Tyr Thr Ala 
             20                  25                  30
Ser Arg Gln His Leu Tyr Val Asp Lys Asn Thr Lys Ile Ile Cys Gln 
         35                  40                  45
Gly Phe Thr Gly Lys Gln Gly Thr Phe His Ser Gln Gln Ala Leu Glu 
     50                  55                  60
Tyr Gly Thr Lys Leu Val Gly Gly Thr Thr Pro Gly Lys Gly Gly Gln 
 65                  70                  75                  80
Thr His Leu Gly Leu Pro Val Phe Asn Thr Val Lys Glu Ala Lys Glu 
                 85                  90                  95
Gln Thr Gly Ala Thr Ala Ser Val Ile Tyr Val Pro Pro Pro Phe Ala 
             100                105                110
Ala Ala Ala Ile Asn Glu Ala Ile Glu Ala Glu Ile Pro Leu Val Val 
         115                120                125
Cys Ile Thr Glu Gly Ile Pro Gln Gln Asp Met Val Arg Val Lys His 
     130                135                140
Lys Leu Leu Arg Gln Glu Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro 
 145                150                155                160
Gly Val Ile Asn Pro Gly Glu Cys Lys Ile Gly Ile Met Pro Gly His 
                 165                170                175
Ile His Lys Lys Gly Arg Ile Gly Ile Val Ser Arg Ser Gly Thr Leu 
             180                185                190
Thr Tyr Glu Ala Val His Gln Thr Thr Gln Val Gly Leu Gly Gln Ser 
         195                200                205
Leu Cys Val Gly Ile Gly Gly Asp Pro Phe Asn Gly Thr Asp Phe Ile 
     210                215                220
Asp Cys Leu Glu Ile Phe Leu Asn Asp Ser Ala Thr Glu Gly Ile Ile 
 225                230                235                240
Leu Ile Gly Glu Ile Gly Gly Asn Ala Glu Glu Asn Ala Ala Glu Phe 
                 245                250                255
Leu Lys Gln His Asn Ser Gly Pro Asn Ser Lys Pro Val Val Ser Phe 
             260                265                270
Ile Ala Gly Leu Thr Ala Pro Pro Gly Arg Arg Met Gly His Ala Gly 
         275                280                285
Ala Ile Ile Ala Gly Gly Lys Gly Gly Ala Lys Glu Lys Ile Ser Ala 
     290                295                300
Leu Gln Ser Ala Gly Val Val Val Ser Met Ser Pro Ala Gln Leu Gly 
 305                310                315                320
Thr Thr Ile Tyr Lys Glu Phe Glu Lys Arg Lys Met Leu 
                 325                330



<210> 2499
<211> 7025
<212> DNA
<213> Rattus norvegicus
<308> J03754
<400> 2499

cgcagggcc  ggccgggcc  ggcgcgcag  aggggcggc  gcagcggca  cggcagcgg  60
ggcggcggc  tcatcgccc  ggagcgggc  cagggtttg  caccctcgg  gtgtggact  120
acagcagcc  aggagacag  gctgaactt  gtcacgcag  ccctagagt  agcaagaca  180
gggttccat  gtgcagctc  tgacacctc  gatgtaacc  gatgacgtg  aggggagct  240
tcccgacca  gtagatgcc  gccccaggg  tgatcagca  gggccccac  gaatggaga  300
tcctgggtc  gcattcctg  gcctcttcg  cccctggac  tcaccccac  cctggggac  360
ctcctcaga  ctctccagt  ctgtcgcca  cccacctca  ccatcgcct  ctcctggga  420
tggaagttg  cctcctgga  ctaataccc  ctggtgagg  tgtactgag  acagccaca  480
acagccatc  cccacaggc  ccttttcca  tgctgaccc  caggcccag  ctgagcaga  540
acttcagca  acatgggtg  tatgaccaa  agcgacttt  actccaaaa  ccaaagaaa  600
gagtcgagc  atgggggcg  gttcgggtg  agcatggag  agctgcgct  cctcatgga  660
ctgcggggc  ctgaggctg  ggtcaagat  aaggagaca  atggggaca  tgaatccat  720
tgccggcgc  tcaaaacct  tcctgttga  ggtttgcca  gcaccgctc  agacctgga  780
aagaggaaa  agattttcg  gcaaaactt  atacctcca  agaaaccaa  aaccttcct  840
cagctggtg  gggaagcac  acaggacgt  acgctcatc  tcctggaga  cgcggccat  900
atctccctg  gactgtcct  ctaccaccc  cccggagag  gcaatgaag  atgtgccac  960
gcccaaggt  gggcagaag  tgaaggtga  gcagaagca  gctggatcg  gggggctgc  1020
atcctgctg  cagtcatct  tgtggtcct  gtcacagcc  tcaatgatt  gagtaaaga  1080
aaacagttc  ggggcctgc  gagccgaat  gagcaggaa  agaagttca  cgtagtccg  1140
gctggccag  tggtccaga  ccctgtggc  gagattgtg  ttggggaca  tgcccagat  1200
aaatacggt  acctccttc  tgctgatgg  ctcttcatc  agggcaatg  cctcaagat  1260
gatgaaagc  cgctcacag  ggagtctga  caggtgcgc  agtctgtgg  taaggaccc  1320
atgttgctg  caggaactc  tgtgatgga  ggctcagga  ggatggtgg  gactgctgt  1380
ggtgtcaac  ctcaaactg  catcatatt  accctgctt  gggctggtg  tgaagagga  1440
gagaagaaa  acaaaaaag  caagcagca  gatggggca  ctgctatgg  aatgcagcc  1500
ctgaagagt  cggagggcg  tgatgcaga  gacaagaag  aagccaaca  gcacaagaa  1560
gagaagtcg  tgcttcagg  caagctcac  aagctggct  tgcagatag  caaggcggg  1620
ctggtgatg  cggccatca  ggtgatcat  ctggtgctc  acttcaccg  ggacacctt  1680
gtggtcaac  agaagccgt  gctgacgga  tgcacaccg  tctacgtgc  gtacttcgt  1740
aagttcttc  tcattggtg  gacggtgct  gtggtcgct  tgcccgagg  cctccctct  1800
gctgtcacc  tctcactgg  ctattccgt  aagaaaatg  tgaaggaca  caacctggt  1860
cgtcacctg  acgcctgtg  gaccatggg  aacgccaca  ccatctgct  agacaagac  1920
ggcacgctg  ccaccaacc  catgaccgt  gtgcaggcc  atgtcggtg  tgtccacta  1980
aaggagatc  ctgatccca  ctccatcaa  gccaagaca  tggagctgc  ggtcaacgc  2040
attgccatc  acagcgcct  caccaccaa  atcctcccc  cagaaaaag  gggcgccct  2100
ccccggcag  tgggcaaca  gacagagtg  ggcctgctg  gcttcgtgc  ggacctgag  2160
caggattac  agccggtac  cagccagat  ccagaggaa  agctgtata  ggtgtacac  2220
ttcaactct  tgcgcaagt  catgagcac  gtcatcaag  tgcctgacg  gagcttccg  2280
atgtacagc  aaggtgctt  ggagattgt  ctcaaaaag  gctgcaaga  tctcagtgg  2340
gcaggggag  cccgtgtct  ccggccccg  gacagggat  agatggtta  gaaggtgat  2400
gagcccatg  cctgtgacg  gctccgtac  atctgtgtg  cctatcgtg  cttccccag  2460
agccctgag  ctgactggg  caatgagaa  gacattctc  atgaactca  ctgcatctg  2520
gtggtgggc  tcgaagacc  agtgcgacc  gaggtccca  aagccatcc  caagtgcca  2580
cgggccggt  tcacagtcc  catggtcac  ggtgacaac  tcaacacag  ccgggccat  2640
gccatcaag  gtggcatta  ccaccctgg  gaggacttc  tgtgcctgg  aggcaaaga  2700
ttcaatcgg  ggatccgca  cgagaaggg  gagattgag  aggagcgga  tgacaagat  2760
tggccaaag  tgagggtgc  ggctcgatc  tcgcccacg  ataagcaca  cctggtcaa  2820
ggcatcatc  acagcacac  cactgagca  cggcaggtg  tggctgtga  aggggatgg  2880
accaacgat  ggcctgctc  caagaaggc  gatgtgggc  tcgcgatgg  catcgcagg  2940
acggatgtg  ccaaggagg  ctcagacat  atcctgaca  acgacaact  cagcagcat  3000
gttaaggca  tgatgtggg  ccgtaatgt  tatgacagc  tatccaaat  cctgcagtt  3060
cagctgact  tcaatgtgg  ggctgtgat  gtggccttc  cgggtgcct  cattacaca  3120
gactcccct  tcaaggcgg  gcagatgct  tgggtgaac  tcatcatgg  cacatttgc  3180
tccctggcc  tggcaacag  gccacccac  gagactctg  tcctgagga  accttacgg  3240
cgcaacaag  cgctcatct  gagaaccat  atgaagaac  tcctgggcc  cgccgtcta  3300
cagctaacc  tcatcttca  cctgctctt  gtgggtgag  agatgttcc  gattgacag  3360
ggaaggaac  ccccgctgc  ctcgccacc  tcggagcac  acaccatca  cttcaacac  3420
ttcgtcatg  tgcagcttt  caacgagat  aacgcccgt  agatccacg  cgagcgtaa  3480
gtcttcgac  gaatcttcc  gaaccccat  ttctgcacc  tcgttctcg  cacttttgc  3540
atccagata  tgattgtgc  gttcggcgg  aaacccttc  gctgctccc  actccagct  3600
gaccagtgg  tgtggtgca  cttcatagg  ctgggagag  tcgtctggg  ccaggtcat  3660
gccaccatc  ctaccagca  gctcaagtt  ctgaaagag  cagggcggc  aacacagaa  3720
gaggagatc  ccgaggaag  gttaaatga  gatgtggaa  agatagacc  cgcagagcg  3780
gagcttcgc  gaggccaga  cctatggtt  cggggcctg  atcggatcc  gacacagat  3840
cgcgtcgtg  aggcgttcc  tagctctct  tatgaaggg  tagaaaaac  cgagtctcg  3900
acctccatc  ataacttca  ggctcatcc  gaattccgg  tcgaagatt  ccagcccca  3960
atccccctc  tcgatgaca  cgacctgga  gaagatgcc  cgctcaagc  gaactcgag  4020
ccgccgtcc  cgctcaaca  gaacaatag  gccatcgac  gcgggatca  cctgacgac  4080
gacacgagc  aatcagcta  ctcttcaag  ccagggagc  ccatccaca  cctggagac  4140
tcgctttag  tgaggcccc  gtcgcctgg  catgctcat  gacccaccg  cacccgcct  4200
caggcgcac  cccttccag  caccaactc  ccgacgcag  aaggagcaa  gggcggaac  4260
cacacagcg  agagagaac  cgtttccac  cacagaccc  ttctctggc  gccatgctg  4320
ttgaactct  tttcactcc  taggccatg  gcggggttg  ccccggggt  atctggagc  4380
gagagtggc  tggattgtt  ttttttttt  tccaaaaca  aaaaaaata  taacgaatt  4440
atttttaaa  aaaagagcc  ttccaggct  cagcccaga  acggaccag  catgcaccc  4500
ccagccact  cgtccccag  atgaatgta  ctggacact  ttaatcccc  ccctcgatt  4560
gttcttgga  ggttaggga  gggagtttt  tgtttgttt  cttaggcgg  aactgcaaa  4620
aggaactgc  aacagactg  tgttcattc  gtccactgg  ctatgaggt  tcaaatgct  4680
gcccagcat  gtctcaaat  tctagatta  tttaataac  ttttgaaat  acagagtag  4740
tttgcacca  tgaaaccca  gaactccac  gacactcat  aggttatat  cgtttcttt  4800
tatctatat  aacgtatac  tcttgaaga  tgtatacgt  cgtatagat  agtagatat  4860
atatatata  atacatata  atacatgga  atataaagt  cctttgccg  catgttgcc  4920
tgtttctgc  taaattgct  tattttaac  tatgtccta  aagaagaat  taatttgtt  4980
acaaacctg  agataatgt  tttggctat  tgtgtggtt  aagaacact  gtggccgag  5040
tgcttacaa  cagcttggc  caacagaca  atcccctgg  ttgcatcct  gaagtttta  5100
gatagccat  ctctgattt  ttgcctgct  tttccgttc  ataacgtta  tactgtggg  5160
agctcaggc  gaaagccaa  agctcccaa  gatccaccc  gaggagcta  gcaacatgc  5220
ccaccgtag  caagggaga  gaggagaga  ggtggttcc  ccgggctgg  aacatggct  5280
tccaggtcc  atgacgtca  tagtgcacc  ggagaagga  ggcttttct  tcaatgaaa  5340
tcgcttgag  ttacagaga  catttcaga  ctgagttgt  tttggcact  tctttgtga  5400
tcaaggtag  gttcagata  cacagatgc  attgtgttg  ttttttttt  ttttttagt  5460
agtagttta  aagtttctt  ccttataaa  agcagcata  atactgctg  catactgga  5520
gagggttgg  acggcttgc  gctttcggt  tttcttttt  aagaatagc  ttttttctc  5580
gcactattt  gatccgaat  aaccttatg  tgtgtacat  gagatgtat  cagtgtgat  5640
tttaaacca  attgtcttc  tgtagttac  acatatact  tagcctttt  acagcaagt  5700
ctgctttcc  agacagaaa  ccattccga  tatcttccc  tatcacagg  gagaaaagg  5760
ggctatccc  tcccccaac  ataacagca  tagtaatcc  aactcaata  gagcttgtc  5820
gtcggcctc  gactgctaa  cactttgtg  gtctcagct  tttttcata  aagaacttt  5880
gtatttaat  caaagtttg  tttgagact  ttcagcata  aatcttttt  cataaactt  5940
tacagtgca  aaagacatt  tgaatacca  gaccggtgg  gtcccgtgc  ttgaggaaa  6000
ccaaacact  tccgcctca  ttgtgaact  catccttca  tctctccct  ctcacaatc  6060
ctcctcgct  ttcagcctg  tccccagcc  tcctccagg  ccagagacc  cttcactaa  6120
caagatgac  gccacttgg  aaaagagcc  tagtccgct  ggagggccc  cgtctggat  6180
gctgtgaaa  acttgagtg  ttggtttgg  gttcaaagt  tgcccgtcc  acctggcca  6240
aatctctct  taaggaaga  tatctctga  ggattctga  tgtatccag  agagagaga  6300
ctgcctctc  agcaggtgg  ccagcccta  atatactca  tggattcca  tacagactc  6360
accagaggc  gcccacagt  cccctccaa  ggagggaag  aaaccccgg  gctgccttc  6420
aacaggata  gtttttctt  gggtttttt  ttgttgttt  attggtttg  gggtttttt  6480
gttttgttt  ttttggggg  gggtttgtt  tttgttttt  ttttttttg  tggggagtc  6540
tttgtcaca  ttttcatcc  accctcctc  attcaacca  gcatctatg  cctcaacct  6600
attccatgc  accagggtt  ttgtgctta  aaaccaggg  ccttgggct  tggaaccaa  6660
cctcaaggg  aaagaggaa  gggttctct  agcagagcc  ggttctcag  cagggagca  6720
aggaagcta  caaggaggc  tgacattag  gctggcttc  cggcgtcag  aatgaggga  6780
agcctatgc  ccagcccct  gttctcaca  tcttccata  acacctaca  aggagatgg  6840
tggttggtc  gaactcact  tagtacaca  agcttgcac  tccgcgtcc  atatctagc  6900
gcatgggat  cgtttggca  ttcacccca  tagggggtc  ataatttat  accattcat  6960
tgtttttat  aattttttt  tctagacaa  aattgtaaa  aaagaattc  ccgtctctg  7020
tcatt  7025



<210> 2500
<211> 1243
<212> PRT
<213> Rattus norvegicus
<308> P11506
<400> 2500

Met Gly Asp Met Thr Asn Ser Asp Phe Tyr Ser Lys Asn Gln Arg Asn 
  1               5                  10                  15
Glu Ser Ser His Gly Gly Glu Phe Gly Cys Ser Met Glu Glu Leu Arg 
             20                  25                  30
Ser Leu Met Glu Leu Arg Gly Thr Glu Ala Val Val Lys Ile Lys Glu 
         35                  40                  45
Thr Tyr Gly Asp Thr Glu Ser Ile Cys Arg Arg Leu Lys Thr Ser Pro 
     50                  55                  60
Val Glu Gly Leu Pro Gly Thr Ala Pro Asp Leu Glu Lys Arg Lys Gln 
 65                  70                  75                  80
Ile Phe Gly Gln Asn Phe Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu 
                 85                  90                  95
Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu 
             100                105                110
Ile Ala Ala Ile Ile Ser Leu Gly Leu Ser Phe Tyr His Pro Pro Gly 
         115                120                125
Glu Ser Asn Glu Gly Cys Ala Thr Ala Gln Gly Gly Ala Glu Asp Glu 
     130                135                140
Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Leu Ser 
 145                150                155                160
Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu 
                 165                170                175
Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln Lys Phe 
             180                185                190
Thr Val Val Arg Ala Gly Gln Val Val Gln Ile Pro Val Ala Glu Ile 
         195                200                205
Val Val Gly Asp Ile Ala Gln Ile Lys Tyr Gly Asp Leu Leu Pro Ala 
     210                215                220
Asp Gly Leu Phe Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser 
 225                230                235                240
Leu Thr Gly Glu Ser Asp Gln Val Arg Lys Ser Val Asp Lys Asp Pro 
                 245                250                255
Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Val 
             260                265                270
Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe Thr Leu 
         275                280                285
Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys Lys Gly Val 
     290                295                300
Lys Lys Gly Asp Gly Leu Gln Leu Pro Ala Ala Asp Gly Ala Ala Pro 
 305                310                315                320
Ala Asn Ala Ala Gly Ser Ala Asn Ala Ser Leu Val Asn Gly Lys Met 
                 325                330                335
Gln Asp Gly Ser Ala Asp Ser Ser Gln Ser Lys Ala Lys Gln Gln Asp 
             340                345                350
Gly Ala Ala Ala Met Glu Met Gln Pro Leu Lys Ser Ala Glu Gly Gly 
         355                360                365
Asp Ala Asp Asp Lys Lys Lys Ala Asn Met His Lys Lys Glu Lys Ser 
     370                375                380
Val Leu Gln Gly Lys Leu Thr Lys Leu Ala Val Gln Ile Gly Lys Ala 
 385                390                395                400
Gly Leu Val Met Ser Ala Ile Thr Val Ile Ile Leu Val Leu Tyr Phe 
                 405                410                415
Thr Val Asp Thr Phe Val Val Asn Lys Lys Pro Trp Leu Thr Glu Cys 
             420                425                430
Thr Pro Val Tyr Val Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Val 
         435                440                445
Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr 
     450                455                460
Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu 
 465                470                475                480
Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile 
                 485                490                495
Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Arg Met Thr Val Val 
             500                505                510
Gln Ala Tyr Val Gly Asp Val His Tyr Lys Glu Ile Pro Asp Pro Ser 
         515                520                525
Ser Ile Asn Ala Lys Thr Leu Glu Leu Leu Val Asn Ala Ile Ala Ile 
     530                535                540
Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro Pro Glu Lys Glu Gly Ala 
 545                550                555                560
Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Gly Leu Leu Gly Phe 
                 565                570                575
Val Leu Asp Leu Arg Gln Asp Tyr Glu Pro Val Arg Ser Gln Met Pro 
             580                585                590
Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser 
         595                600                605
Met Ser Thr Val Ile Lys Met Pro Asp Glu Ser Phe Arg Met Tyr Ser 
     610                615                620
Lys Gly Ala Ser Glu Ile Val Leu Lys Lys Cys Cys Lys Ile Leu Ser 
 625                630                635                640
Gly Ala Gly Glu Pro Arg Val Phe Arg Pro Arg Asp Arg Asp Glu Met 
                 645                650                655
Val Lys Lys Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile 
             660                665                670
Cys Val Ala Tyr Arg Asp Phe Pro Ser Ser Pro Glu Pro Asp Trp Asp 
         675                680                685
Asn Glu Asn Asp Ile Leu Asn Glu Leu Thr Cys Ile Cys Val Val Gly 
     690                695                700
Ile Glu Asp Pro Val Arg Pro Glu Val Pro Glu Ala Ile Arg Lys Cys 
 705                710                715                720
Gln Arg Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn 
                 725                730                735
Thr Ala Arg Ala Ile Ala Ile Lys Cys Gly Ile Ile His Pro Gly Glu 
             740                745                750
Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Arg Ile Arg Asn 
         755                760                765
Glu Lys Gly Glu Ile Glu Gln Glu Arg Ile Asp Lys Ile Trp Pro Lys 
     770                775                780
Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val 
 785                790                795                800
Lys Gly Ile Ile Asp Ser Thr His Thr Glu Gln Arg Gln Val Val Ala 
                 805                810                815
Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp 
             820                825                830
Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala 
         835                840                845
Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Ser Ser Ile Val Lys Ala 
     850                855                860
Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln 
 865                870                875                880
Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly 
                 885                890                895
Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp 
             900                905                910
Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu 
         915                920                925
Pro Pro Thr Glu Thr Leu Leu Leu Arg Lys Pro Tyr Gly Arg Asn Lys 
     930                935                940
Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Val 
 945                950                955                960
Tyr Gln Leu Thr Leu Ile Phe Thr Leu Leu Phe Val Gly Glu Lys Met 
                 965                970                975
Phe Gln Ile Asp Ser Gly Arg Asn Ala Pro Leu His Ser Pro Pro Ser 
             980                985                990
Glu His Tyr Thr Ile Ile Phe Asn Thr Phe Val Met Met Gln Leu Phe 
         995                1000                1005
Asn Glu Ile Asn Ala Arg Lys Ile His Gly Glu Arg Asn Val Phe Asp 
     1010                1015                1020
Gly Ile Phe Arg Asn Pro Ile Phe Cys Thr Ile Val Leu Gly Thr Phe 
 1025                1030                1035                1040
Ala Ile Gln Ile Val Ile Val Gln Phe Gly Gly Lys Pro Phe Ser Cys 
                 1045                1050                1055
Ser Pro Leu Gln Leu Asp Gln Trp Met Trp Cys Ile Phe Ile Gly Leu 
             1060                1065                1070
Gly Glu Leu Val Trp Gly Gln Val Ile Ala Thr Ile Pro Thr Ser Arg 
         1075                1080                1085
Leu Lys Phe Leu Lys Glu Ala Gly Arg Leu Thr Gln Lys Glu Glu Ile 
     1090                1095                1100
Pro Glu Glu Glu Leu Asn Glu Asp Val Glu Glu Ile Asp His Ala Glu 
 1105                1110                1115                1120
Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg 
                 1125                1130                1135
Ile Gln Thr Gln Ile Arg Val Val Lys Ala Phe Arg Ser Ser Leu Tyr 
             1140                1145                1150
Glu Gly Leu Glu Lys Pro Glu Ser Arg Thr Ser Ile His Asn Phe Met 
         1155                1160                1165
Ala His Pro Glu Phe Arg Ile Glu Asp Ser Gln Pro His Ile Pro Leu 
     1170                1175                1180
Ile Asp Asp Thr Asp Leu Glu Glu Asp Ala Ala Leu Lys Gln Asn Ser 
 1185                1190                1195                1200
Ser Pro Pro Ser Ser Leu Asn Lys Asn Asn Ser Ala Ile Asp Ser Gly 
                 1205                1210                1215
Ile Asn Leu Thr Thr Asp Thr Ser Lys Ser Ala Thr Ser Ser Ser Pro 
             1220                1225                1230
Gly Ser Pro Ile His Ser Leu Glu Thr Ser Leu 
         1235                1240



<210> 2501
<211> 4421
<212> DNA
<213> Homo sapiens
<308> L00620
<400> 2501

gcaaggacc  cagcaaaca  gggtgacat  accaacagc  acttttact  caaaaacca  60
agaaatgag  cgagccatg  gggcgagtt  gggtgcaca  tggaggagc  ccgctccct  120
atggagctg  ggggcactg  ggctgtggt  aagatcaag  agacttatg  ggacaccga  180
gccatctgc  ggcgcctca  aacctcacc  gttgaaggt  tgccgggca  cgctccaga  240
ctggaaaag  gaaagcaaa  ttttgggca  aactttata  ctccaaaga  gccaaaaac  300
ttcctgcag  tcgtgtggg  ggcgctgca  gacgtgacg  tcatcatcc  ggagattgc  360
gccatcatc  ccctggggc  gtccttcta  caccgcccc  gcgagggca  cgaaggatg  420
gcgacggcc  agggtgggg  agaggatga  ggagaggca  aggcaggtt  gatcgaggg  480
gccgccatt  tcctctcag  tatctgtgt  gtcctggtc  cggccttca  tgactggag  540
aaagagaaa  agttccggg  cctgcagag  cgcatcgag  aggaacaga  atttaccgt  600
gtccgggct  gccaggtgg  ccagatccc  gtggctgag  tcgtggttg  ggacatagc  660
caggtcaaa  atggtgacc  cctccctgc  gacggactc  tcatccagg  caatgacct  720
aagattgat  aaagctccc  aactggaga  tctgaccag  tgcgcaagt  cgtggacaa  780
gaccccatg  tgctgtcag  aacccacgt  atggagggc  caggacgga  gttggtgac  840
gctgtgggt  tgaactctc  gactggcat  atctttacc  tcctggggg  tggtggtga  900
gaggaagag  agaaagaca  aaaagccaa  cagcaggac  gggcagccg  catggagat  960
cagcccctc  agagtgccg  gggcggcga  gctgacgac  ggaagaagg  cagcatgca  1020
aagaaggag  agtccgtgc  gcagggcaa  ctcaccaag  tggctgtgc  gatcgggaa  1080
gcgggcttg  tgatgtcag  catcacggt  atcatcctg  tgctctact  cactgtgga  1140
accttcgtg  tcaacaaga  gccgtggct  cctgagtgc  cgcccgtct  cgtgcagta  1200
tttgtcaag  tcttcatca  tggcgtgac  gtgctggtg  tcgccgtgc  cgaggggct  1260
cctctggcc  tcaccatct  gttggccta  tcggtgaag  aaatgatga  ggacaacaa  1320
ctggtacgc  acctggatg  ctgtgagac  atgggcaat  ccacagcca  ctgctcaga  1380
aagacaggc  cgctgacca  caatcgcat  acagtggta  aggcctatg  cgacgacgt  1440
cactataaa  agatccccg  ccccagctc  atcaacacc  agactatgg  gctgctgat  1500
aatgccatc  ccatcaaca  cgcctacac  accaagatt  tgcccccag  gaaggaggg  1560
gccctgcct  ggcaggtgg  caacaagac  gagtgcggc  tgctgggct  cgtgctgga  1620
ctgaagcag  actacgagc  cgtgcgcag  cagatgcca  aggagaagt  gtacaaagt  1680
tacaccttc  actccgtgc  caagtccat  agcactgtc  tcaagctgc  cgacgagag  1740
ttccgcatg  acagcaagg  ggcttctga  atcgtgctc  agaagtgct  caaaatcct  1800
aatggggcg  gagagcctc  tgtcttccg  ccccgcgac  gggacgaga  ggtaaagaa  1860
gtgattgag  ccatggctt  cgatgggct  cgcactatc  gcgtggcct  ccgcgactt  1920
cccagcagc  cggagccgg  ctgggacaa  gagaatgac  tcctcaacg  actcacctg  1980
atctgcgtg  tgggcatcg  ggacccggt  cggccagag  tcccagaag  catccgcaa  2040
tgccagcgg  caggcatca  ggtccgcat  gtcactggc  acaatatca  cacggctcg  2100
gccatcgcc  tcaagtgtg  catcatcca  cctggggag  actttctgt  cctcgaggg  2160
aaggagttc  acaggagga  ccgcaacga  aagggggag  ttgagcagg  gcgaattga  2220
aagatctgg  caaagctgc  ggtgctggc  cgctcctcc  caacggaca  gcataccct  2280
gttaaaggc  tcatcgaca  cacacacac  gagcagcgg  aggtggtgg  cgtgacggg  2340
gacgggacc  acgacgggc  tgcactcaa  aaggccgac  tgggcttcg  catgggcat  2400
gcaggcact  acgtggcca  ggaggcctc  gacatcatc  tgacagacg  caatttcag  2460
agcatcgtc  aggcagtga  gtggggccg  aacgtctat  acagcatct  caaattctt  2520
cagttccag  tcaccgtca  cgtggtggc  gtgattgtg  ccttcacag  cgcctgcat  2580
acgcaggac  cccctctga  ggccgtgca  atgctctgg  tgaacctca  catggacac  2640
tttgcctcg  tggcactgg  cactgagcc  cccacggag  ccctgctgc  gaggaagcc  2700
tacggccgc  acaagccgc  catctccag  accatgatg  agaacatcc  gggccatgc  2760
gtctaccag  ttgccctca  cttcaccct  ctctttgtt  gcgagaaga  gttccagat  2820
gacagcggg  ggaacgcgc  cctgcattc  ccaccctca  aacattaca  catcatctt  2880
aacaccttc  tcatgatgc  gctcttcaa  gagatcaac  cccgcaaga  ccacggcga  2940
cgcaatgtc  ttgacggca  cttccggaa  cccatcttc  gcaccatcg  gctgggcac  3000
tttgccatc  agatagtga  cgtgcagtt  ggagggaag  cattcagct  ctctccact  3060
cagctggac  agtggatgt  gtgcatatt  attgggtta  gagagctcg  ttggggcca  3120
gtcatcgcc  ccatcccga  cagcagact  aagttcctc  aggaggcag  caggctcac  3180
cagaaggag  agatcccgg  ggaggagct  aacgaggac  tggaggaga  cgaccacgc  3240
gagcgggag  tgcggcggg  ccagatcct  tggttccga  gcctgaatc  gatccagac  3300
cagatccgc  tcgtgaagg  gttccgtag  tctctctat  aaggtttag  aaagcctga  3360
tctcgaacc  ccatccata  cttcatggc  catcctgaa  tccggatcg  agattccca  3420
ccccacatc  ccctcattg  tgacaccga  ctggaagaa  atgccgcgc  caagcagaa  3480
tcgagcccg  cgtcatccc  caacaagaa  aacagcgcc  tcgacagtg  gatcaacct  3540
acgaccgac  caagcaaat  agctacctc  tcaagtcca  ggagcccca  ccacagcct  3600
gagacgtcg  tttagctga  gaccctgtc  cctgcccgc  cgccctcat  gaccccgct  3660
tcacccgct  tccgggcac  catccatcc  ggcacccaa  tcacccaag  agcaacgag  3720
aacaatcgg  aaccaaata  tggagagaa  accaacgtt  ccacccaca  accctttct  3780
tggctgcga  gctgtttga  ctctttttc  cttcaaggc  aggggcggg  tctccactg  3840
gggcttacg  gagtgagcg  ttttcccaa  acaagccct  cctggctcc  acccagaca  3900
ggaccagcc  tgcacccgc  cagtcacca  gtcccccgc  tgaatgtac  gtacacttt  3960
aatcctccc  ttgtttggt  tttgggggt  ggggagggg  ttttgtttg  ttgtttgtt  4020
tcttaggcg  gaactgcaa  cagactctt  tctgagact  tttatccaa  ccactggtc  4080
gtgagtttt  gaaacgctt  cacagcatg  tctcagttg  atagattaa  ttaataact  4140
tttgaaatt  cagagctta  ctcgcctag  agatttgca  caatggaac  gaagaactt  4200
atagacact  acaaggtta  atccatttc  ttgtatcta  atcaacgta  acttttccg  4260
gactgtata  gtccatata  ataggtaga  atatatata  atatataaa  atatataca  4320
ggatatata  agtttcttt  ccggcatgt  gccttgttt  cgcttaaat  gctctattt  4380
aacttattt  tgtcctaaa  gaagaatgt  atttgttta  a  4421



<210> 2502
<211> 1243
<212> PRT
<213> Homo sapiens
<308> Q01814
<400> 2502

Met Gly Asp Met Thr Asn Ser Asp Phe Tyr Ser Lys Asn Gln Arg Asn 
  1               5                  10                  15
Glu Ser Ser His Gly Gly Glu Phe Gly Cys Thr Met Glu Glu Leu Arg 
             20                  25                  30
Ser Leu Met Glu Leu Arg Gly Thr Glu Ala Val Val Lys Ile Lys Glu 
         35                  40                  45
Thr Tyr Gly Asp Thr Glu Ala Ile Cys Arg Arg Leu Lys Thr Ser Pro 
     50                  55                  60
Val Glu Gly Leu Pro Gly Thr Ala Pro Asp Leu Glu Lys Arg Lys Gln 
 65                  70                  75                  80
Ile Phe Gly Gln Asn Phe Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu 
                 85                  90                  95
Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu 
             100                105                110
Ile Ala Ala Ile Ile Ser Leu Gly Leu Ser Phe Tyr His Pro Pro Gly 
         115                120                125
Glu Gly Asn Glu Gly Cys Ala Thr Ala Gln Gly Gly Ala Glu Asp Glu 
     130                135                140
Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Leu Ser 
 145                150                155                160
Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu 
                 165                170                175
Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln Lys Phe 
             180                185                190
Thr Val Val Arg Ala Gly Gln Val Val Gln Ile Pro Val Ala Glu Ile 
         195                200                205
Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala 
     210                215                220
Asp Gly Leu Phe Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser 
 225                230                235                240
Leu Thr Gly Glu Ser Asp Gln Val Arg Lys Ser Val Asp Lys Asp Pro 
                 245                250                255
Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Leu 
             260                265                270
Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe Thr Leu 
         275                280                285
Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys Lys Gly Val 
     290                295                300
Lys Lys Gly Asp Gly Leu Gln Leu Pro Ala Ala Asp Gly Ala Ala Ala 
 305                310                315                320
Ser Asn Ala Ala Asp Ser Ala Asn Ala Ser Leu Val Asn Gly Lys Met 
                 325                330                335
Gln Asp Gly Asn Val Asp Ala Ser Gln Ser Lys Ala Lys Gln Gln Asp 
             340                345                350
Gly Ala Ala Ala Met Glu Met Gln Pro Leu Lys Ser Ala Glu Gly Gly 
         355                360                365
Asp Ala Asp Asp Arg Lys Lys Ala Ser Met His Lys Lys Glu Lys Ser 
     370                375                380
Val Leu Gln Gly Lys Leu Thr Lys Leu Ala Val Gln Ile Gly Lys Ala 
 385                390                395                400
Gly Leu Val Met Ser Ala Ile Thr Val Ile Ile Leu Val Leu Tyr Phe 
                 405                410                415
Thr Val Asp Thr Phe Val Val Asn Lys Lys Pro Trp Leu Pro Glu Cys 
             420                425                430
Thr Pro Val Tyr Val Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Val 
         435                440                445
Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr 
     450                455                460
Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu 
 465                470                475                480
Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile 
                 485                490                495
Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Arg Met Thr Val Val 
             500                505                510
Gln Ala Tyr Val Gly Asp Val His Tyr Lys Glu Ile Pro Asp Pro Ser 
         515                520                525
Ser Ile Asn Thr Lys Thr Met Glu Leu Leu Ile Asn Ala Ile Ala Ile 
     530                535                540
Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro Pro Glu Lys Glu Gly Ala 
 545                550                555                560
Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Gly Leu Leu Gly Phe 
                 565                570                575
Val Leu Asp Leu Lys Gln Asp Tyr Glu Pro Val Arg Ser Gln Met Pro 
             580                585                590
Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser 
         595                600                605
Met Ser Thr Val Ile Lys Leu Pro Asp Glu Ser Phe Arg Met Tyr Ser 
     610                615                620
Lys Gly Ala Ser Glu Ile Val Leu Lys Lys Cys Cys Lys Ile Leu Asn 
 625                630                635                640
Gly Ala Gly Glu Pro Arg Val Phe Arg Pro Arg Asp Arg Asp Glu Met 
                 645                650                655
Val Lys Lys Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile 
             660                665                670
Cys Val Ala Tyr Arg Asp Phe Pro Ser Ser Pro Glu Pro Asp Trp Asp 
         675                680                685
Asn Glu Asn Asp Ile Leu Asn Glu Leu Thr Cys Ile Cys Val Val Gly 
     690                695                700
Ile Glu Asp Pro Val Arg Pro Glu Val Pro Glu Ala Ile Arg Lys Cys 
 705                710                715                720
Gln Arg Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn 
                 725                730                735
Thr Ala Arg Ala Ile Ala Ile Lys Cys Gly Ile Ile His Pro Gly Glu 
             740                745                750
Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Arg Ile Arg Asn 
         755                760                765
Glu Lys Gly Glu Ile Glu Gln Glu Arg Ile Asp Lys Ile Trp Pro Lys 
     770                775                780
Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val 
 785                790                795                800
Lys Gly Ile Ile Asp Ser Thr His Thr Glu Gln Arg Gln Val Val Ala 
                 805                810                815
Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp 
             820                825                830
Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala 
         835                840                845
Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Ser Ser Ile Val Lys Ala 
     850                855                860
Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln 
 865                870                875                880
Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly 
                 885                890                895
Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp 
             900                905                910
Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu 
         915                920                925
Pro Pro Thr Glu Thr Leu Leu Leu Arg Lys Pro Tyr Gly Arg Asn Lys 
     930                935                940
Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Val 
 945                950                955                960
Tyr Gln Leu Ala Leu Ile Phe Thr Leu Leu Phe Val Gly Glu Lys Met 
                 965                970                975
Phe Gln Ile Asp Ser Gly Arg Asn Ala Pro Leu His Ser Pro Pro Ser 
             980                985                990
Glu His Tyr Thr Ile Ile Phe Asn Thr Phe Val Met Met Gln Leu Phe 
         995                1000                1005
Asn Glu Ile Asn Ala Arg Lys Ile His Gly Glu Arg Asn Val Phe Asp 
     1010                1015                1020
Gly Ile Phe Arg Asn Pro Ile Phe Cys Thr Ile Val Leu Gly Thr Phe 
 1025                1030                1035                1040
Ala Ile Gln Ile Val Ile Val Gln Phe Gly Gly Lys Pro Phe Ser Cys 
                 1045                1050                1055
Ser Pro Leu Gln Leu Asp Gln Trp Met Trp Cys Ile Phe Ile Gly Leu 
             1060                1065                1070
Gly Glu Leu Val Trp Gly Gln Val Ile Ala Thr Ile Pro Thr Ser Arg 
         1075                1080                1085
Leu Lys Phe Leu Lys Glu Ala Gly Arg Leu Thr Gln Lys Glu Glu Ile 
     1090                1095                1100
Pro Glu Glu Glu Leu Asn Glu Asp Val Glu Glu Ile Asp His Ala Glu 
 1105                1110                1115                1120
Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg 
                 1125                1130                1135
Ile Gln Thr Gln Ile Arg Val Val Lys Ala Phe Arg Ser Ser Leu Tyr 
             1140                1145                1150
Glu Gly Leu Glu Lys Pro Glu Ser Arg Thr Ser Ile His Asn Phe Met 
         1155                1160                1165
Ala His Pro Glu Phe Arg Ile Glu Asp Ser Gln Pro His Ile Pro Leu 
     1170                1175                1180
Ile Asp Asp Thr Asp Leu Glu Glu Asp Ala Ala Leu Lys Gln Asn Ser 
 1185                1190                1195                1200
Ser Pro Pro Ser Ser Leu Asn Lys Asn Asn Ser Ala Ile Asp Ser Gly 
                 1205                1210                1215
Ile Asn Leu Thr Thr Asp Thr Ser Lys Ser Ala Thr Ser Ser Ser Pro 
             1220                1225                1230
Gly Ser Pro Ile His Ser Leu Glu Thr Ser Leu 
         1235                1240



<210> 2503
<211> 7025
<212> DNA
<213> Rattus norvegicus
<308> J03754
<400> 2503

cgcagggcc  ggccgggcc  ggcgcgcag  aggggcggc  gcagcggca  cggcagcgg  60
ggcggcggc  tcatcgccc  ggagcgggc  cagggtttg  caccctcgg  gtgtggact  120
acagcagcc  aggagacag  gctgaactt  gtcacgcag  ccctagagt  agcaagaca  180
gggttccat  gtgcagctc  tgacacctc  gatgtaacc  gatgacgtg  aggggagct  240
tcccgacca  gtagatgcc  gccccaggg  tgatcagca  gggccccac  gaatggaga  300
tcctgggtc  gcattcctg  gcctcttcg  cccctggac  tcaccccac  cctggggac  360
ctcctcaga  ctctccagt  ctgtcgcca  cccacctca  ccatcgcct  ctcctggga  420
tggaagttg  cctcctgga  ctaataccc  ctggtgagg  tgtactgag  acagccaca  480
acagccatc  cccacaggc  ccttttcca  tgctgaccc  caggcccag  ctgagcaga  540
acttcagca  acatgggtg  tatgaccaa  agcgacttt  actccaaaa  ccaaagaaa  600
gagtcgagc  atgggggcg  gttcgggtg  agcatggag  agctgcgct  cctcatgga  660
ctgcggggc  ctgaggctg  ggtcaagat  aaggagaca  atggggaca  tgaatccat  720
tgccggcgc  tcaaaacct  tcctgttga  ggtttgcca  gcaccgctc  agacctgga  780
aagaggaaa  agattttcg  gcaaaactt  atacctcca  agaaaccaa  aaccttcct  840
cagctggtg  gggaagcac  acaggacgt  acgctcatc  tcctggaga  cgcggccat  900
atctccctg  gactgtcct  ctaccaccc  cccggagag  gcaatgaag  atgtgccac  960
gcccaaggt  gggcagaag  tgaaggtga  gcagaagca  gctggatcg  gggggctgc  1020
atcctgctg  cagtcatct  tgtggtcct  gtcacagcc  tcaatgatt  gagtaaaga  1080
aaacagttc  ggggcctgc  gagccgaat  gagcaggaa  agaagttca  cgtagtccg  1140
gctggccag  tggtccaga  ccctgtggc  gagattgtg  ttggggaca  tgcccagat  1200
aaatacggt  acctccttc  tgctgatgg  ctcttcatc  agggcaatg  cctcaagat  1260
gatgaaagc  cgctcacag  ggagtctga  caggtgcgc  agtctgtgg  taaggaccc  1320
atgttgctg  caggaactc  tgtgatgga  ggctcagga  ggatggtgg  gactgctgt  1380
ggtgtcaac  ctcaaactg  catcatatt  accctgctt  gggctggtg  tgaagagga  1440
gagaagaaa  acaaaaaag  caagcagca  gatggggca  ctgctatgg  aatgcagcc  1500
ctgaagagt  cggagggcg  tgatgcaga  gacaagaag  aagccaaca  gcacaagaa  1560
gagaagtcg  tgcttcagg  caagctcac  aagctggct  tgcagatag  caaggcggg  1620
ctggtgatg  cggccatca  ggtgatcat  ctggtgctc  acttcaccg  ggacacctt  1680
gtggtcaac  agaagccgt  gctgacgga  tgcacaccg  tctacgtgc  gtacttcgt  1740
aagttcttc  tcattggtg  gacggtgct  gtggtcgct  tgcccgagg  cctccctct  1800
gctgtcacc  tctcactgg  ctattccgt  aagaaaatg  tgaaggaca  caacctggt  1860
cgtcacctg  acgcctgtg  gaccatggg  aacgccaca  ccatctgct  agacaagac  1920
ggcacgctg  ccaccaacc  catgaccgt  gtgcaggcc  atgtcggtg  tgtccacta  1980
aaggagatc  ctgatccca  ctccatcaa  gccaagaca  tggagctgc  ggtcaacgc  2040
attgccatc  acagcgcct  caccaccaa  atcctcccc  cagaaaaag  gggcgccct  2100
ccccggcag  tgggcaaca  gacagagtg  ggcctgctg  gcttcgtgc  ggacctgag  2160
caggattac  agccggtac  cagccagat  ccagaggaa  agctgtata  ggtgtacac  2220
ttcaactct  tgcgcaagt  catgagcac  gtcatcaag  tgcctgacg  gagcttccg  2280
atgtacagc  aaggtgctt  ggagattgt  ctcaaaaag  gctgcaaga  tctcagtgg  2340
gcaggggag  cccgtgtct  ccggccccg  gacagggat  agatggtta  gaaggtgat  2400
gagcccatg  cctgtgacg  gctccgtac  atctgtgtg  cctatcgtg  cttccccag  2460
agccctgag  ctgactggg  caatgagaa  gacattctc  atgaactca  ctgcatctg  2520
gtggtgggc  tcgaagacc  agtgcgacc  gaggtccca  aagccatcc  caagtgcca  2580
cgggccggt  tcacagtcc  catggtcac  ggtgacaac  tcaacacag  ccgggccat  2640
gccatcaag  gtggcatta  ccaccctgg  gaggacttc  tgtgcctgg  aggcaaaga  2700
ttcaatcgg  ggatccgca  cgagaaggg  gagattgag  aggagcgga  tgacaagat  2760
tggccaaag  tgagggtgc  ggctcgatc  tcgcccacg  ataagcaca  cctggtcaa  2820
ggcatcatc  acagcacac  cactgagca  cggcaggtg  tggctgtga  aggggatgg  2880
accaacgat  ggcctgctc  caagaaggc  gatgtgggc  tcgcgatgg  catcgcagg  2940
acggatgtg  ccaaggagg  ctcagacat  atcctgaca  acgacaact  cagcagcat  3000
gttaaggca  tgatgtggg  ccgtaatgt  tatgacagc  tatccaaat  cctgcagtt  3060
cagctgact  tcaatgtgg  ggctgtgat  gtggccttc  cgggtgcct  cattacaca  3120
gactcccct  tcaaggcgg  gcagatgct  tgggtgaac  tcatcatgg  cacatttgc  3180
tccctggcc  tggcaacag  gccacccac  gagactctg  tcctgagga  accttacgg  3240
cgcaacaag  cgctcatct  gagaaccat  atgaagaac  tcctgggcc  cgccgtcta  3300
cagctaacc  tcatcttca  cctgctctt  gtgggtgag  agatgttcc  gattgacag  3360
ggaaggaac  ccccgctgc  ctcgccacc  tcggagcac  acaccatca  cttcaacac  3420
ttcgtcatg  tgcagcttt  caacgagat  aacgcccgt  agatccacg  cgagcgtaa  3480
gtcttcgac  gaatcttcc  gaaccccat  ttctgcacc  tcgttctcg  cacttttgc  3540
atccagata  tgattgtgc  gttcggcgg  aaacccttc  gctgctccc  actccagct  3600
gaccagtgg  tgtggtgca  cttcatagg  ctgggagag  tcgtctggg  ccaggtcat  3660
gccaccatc  ctaccagca  gctcaagtt  ctgaaagag  cagggcggc  aacacagaa  3720
gaggagatc  ccgaggaag  gttaaatga  gatgtggaa  agatagacc  cgcagagcg  3780
gagcttcgc  gaggccaga  cctatggtt  cggggcctg  atcggatcc  gacacagat  3840
cgcgtcgtg  aggcgttcc  tagctctct  tatgaaggg  tagaaaaac  cgagtctcg  3900
acctccatc  ataacttca  ggctcatcc  gaattccgg  tcgaagatt  ccagcccca  3960
atccccctc  tcgatgaca  cgacctgga  gaagatgcc  cgctcaagc  gaactcgag  4020
ccgccgtcc  cgctcaaca  gaacaatag  gccatcgac  gcgggatca  cctgacgac  4080
gacacgagc  aatcagcta  ctcttcaag  ccagggagc  ccatccaca  cctggagac  4140
tcgctttag  tgaggcccc  gtcgcctgg  catgctcat  gacccaccg  cacccgcct  4200
caggcgcac  cccttccag  caccaactc  ccgacgcag  aaggagcaa  gggcggaac  4260
cacacagcg  agagagaac  cgtttccac  cacagaccc  ttctctggc  gccatgctg  4320
ttgaactct  tttcactcc  taggccatg  gcggggttg  ccccggggt  atctggagc  4380
gagagtggc  tggattgtt  ttttttttt  tccaaaaca  aaaaaaata  taacgaatt  4440
atttttaaa  aaaagagcc  ttccaggct  cagcccaga  acggaccag  catgcaccc  4500
ccagccact  cgtccccag  atgaatgta  ctggacact  ttaatcccc  ccctcgatt  4560
gttcttgga  ggttaggga  gggagtttt  tgtttgttt  cttaggcgg  aactgcaaa  4620
aggaactgc  aacagactg  tgttcattc  gtccactgg  ctatgaggt  tcaaatgct  4680
gcccagcat  gtctcaaat  tctagatta  tttaataac  ttttgaaat  acagagtag  4740
tttgcacca  tgaaaccca  gaactccac  gacactcat  aggttatat  cgtttcttt  4800
tatctatat  aacgtatac  tcttgaaga  tgtatacgt  cgtatagat  agtagatat  4860
atatatata  atacatata  atacatgga  atataaagt  cctttgccg  catgttgcc  4920
tgtttctgc  taaattgct  tattttaac  tatgtccta  aagaagaat  taatttgtt  4980
acaaacctg  agataatgt  tttggctat  tgtgtggtt  aagaacact  gtggccgag  5040
tgcttacaa  cagcttggc  caacagaca  atcccctgg  ttgcatcct  gaagtttta  5100
gatagccat  ctctgattt  ttgcctgct  tttccgttc  ataacgtta  tactgtggg  5160
agctcaggc  gaaagccaa  agctcccaa  gatccaccc  gaggagcta  gcaacatgc  5220
ccaccgtag  caagggaga  gaggagaga  ggtggttcc  ccgggctgg  aacatggct  5280
tccaggtcc  atgacgtca  tagtgcacc  ggagaagga  ggcttttct  tcaatgaaa  5340
tcgcttgag  ttacagaga  catttcaga  ctgagttgt  tttggcact  tctttgtga  5400
tcaaggtag  gttcagata  cacagatgc  attgtgttg  ttttttttt  ttttttagt  5460
agtagttta  aagtttctt  ccttataaa  agcagcata  atactgctg  catactgga  5520
gagggttgg  acggcttgc  gctttcggt  tttcttttt  aagaatagc  ttttttctc  5580
gcactattt  gatccgaat  aaccttatg  tgtgtacat  gagatgtat  cagtgtgat  5640
tttaaacca  attgtcttc  tgtagttac  acatatact  tagcctttt  acagcaagt  5700
ctgctttcc  agacagaaa  ccattccga  tatcttccc  tatcacagg  gagaaaagg  5760
ggctatccc  tcccccaac  ataacagca  tagtaatcc  aactcaata  gagcttgtc  5820
gtcggcctc  gactgctaa  cactttgtg  gtctcagct  tttttcata  aagaacttt  5880
gtatttaat  caaagtttg  tttgagact  ttcagcata  aatcttttt  cataaactt  5940
tacagtgca  aaagacatt  tgaatacca  gaccggtgg  gtcccgtgc  ttgaggaaa  6000
ccaaacact  tccgcctca  ttgtgaact  catccttca  tctctccct  ctcacaatc  6060
ctcctcgct  ttcagcctg  tccccagcc  tcctccagg  ccagagacc  cttcactaa  6120
caagatgac  gccacttgg  aaaagagcc  tagtccgct  ggagggccc  cgtctggat  6180
gctgtgaaa  acttgagtg  ttggtttgg  gttcaaagt  tgcccgtcc  acctggcca  6240
aatctctct  taaggaaga  tatctctga  ggattctga  tgtatccag  agagagaga  6300
ctgcctctc  agcaggtgg  ccagcccta  atatactca  tggattcca  tacagactc  6360
accagaggc  gcccacagt  cccctccaa  ggagggaag  aaaccccgg  gctgccttc  6420
aacaggata  gtttttctt  gggtttttt  ttgttgttt  attggtttg  gggtttttt  6480
gttttgttt  ttttggggg  gggtttgtt  tttgttttt  ttttttttg  tggggagtc  6540
tttgtcaca  ttttcatcc  accctcctc  attcaacca  gcatctatg  cctcaacct  6600
attccatgc  accagggtt  ttgtgctta  aaaccaggg  ccttgggct  tggaaccaa  6660
cctcaaggg  aaagaggaa  gggttctct  agcagagcc  ggttctcag  cagggagca  6720
aggaagcta  caaggaggc  tgacattag  gctggcttc  cggcgtcag  aatgaggga  6780
agcctatgc  ccagcccct  gttctcaca  tcttccata  acacctaca  aggagatgg  6840
tggttggtc  gaactcact  tagtacaca  agcttgcac  tccgcgtcc  atatctagc  6900
gcatgggat  cgtttggca  ttcacccca  tagggggtc  ataatttat  accattcat  6960
tgtttttat  aattttttt  tctagacaa  aattgtaaa  aaagaattc  ccgtctctg  7020
tcatt  7025



<210> 2504
<211> 1243
<212> PRT
<213> Rattus norvegicus
<308> P11506
<400> 2504

Met Gly Asp Met Thr Asn Ser Asp Phe Tyr Ser Lys Asn Gln Arg Asn 
  1               5                  10                  15
Glu Ser Ser His Gly Gly Glu Phe Gly Cys Ser Met Glu Glu Leu Arg 
             20                  25                  30
Ser Leu Met Glu Leu Arg Gly Thr Glu Ala Val Val Lys Ile Lys Glu 
         35                  40                  45
Thr Tyr Gly Asp Thr Glu Ser Ile Cys Arg Arg Leu Lys Thr Ser Pro 
     50                  55                  60
Val Glu Gly Leu Pro Gly Thr Ala Pro Asp Leu Glu Lys Arg Lys Gln 
 65                  70                  75                  80
Ile Phe Gly Gln Asn Phe Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu 
                 85                  90                  95
Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu 
             100                105                110
Ile Ala Ala Ile Ile Ser Leu Gly Leu Ser Phe Tyr His Pro Pro Gly 
         115                120                125
Glu Ser Asn Glu Gly Cys Ala Thr Ala Gln Gly Gly Ala Glu Asp Glu 
     130                135                140
Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Leu Ser 
 145                150                155                160
Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu 
                 165                170                175
Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln Lys Phe 
             180                185                190
Thr Val Val Arg Ala Gly Gln Val Val Gln Ile Pro Val Ala Glu Ile 
         195                200                205
Val Val Gly Asp Ile Ala Gln Ile Lys Tyr Gly Asp Leu Leu Pro Ala 
     210                215                220
Asp Gly Leu Phe Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser 
 225                230                235                240
Leu Thr Gly Glu Ser Asp Gln Val Arg Lys Ser Val Asp Lys Asp Pro 
                 245                250                255
Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Val 
             260                265                270
Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe Thr Leu 
         275                280                285
Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys Lys Gly Val 
     290                295                300
Lys Lys Gly Asp Gly Leu Gln Leu Pro Ala Ala Asp Gly Ala Ala Pro 
 305                310                315                320
Ala Asn Ala Ala Gly Ser Ala Asn Ala Ser Leu Val Asn Gly Lys Met 
                 325                330                335
Gln Asp Gly Ser Ala Asp Ser Ser Gln Ser Lys Ala Lys Gln Gln Asp 
             340                345                350
Gly Ala Ala Ala Met Glu Met Gln Pro Leu Lys Ser Ala Glu Gly Gly 
         355                360                365
Asp Ala Asp Asp Lys Lys Lys Ala Asn Met His Lys Lys Glu Lys Ser 
     370                375                380
Val Leu Gln Gly Lys Leu Thr Lys Leu Ala Val Gln Ile Gly Lys Ala 
 385                390                395                400
Gly Leu Val Met Ser Ala Ile Thr Val Ile Ile Leu Val Leu Tyr Phe 
                 405                410                415
Thr Val Asp Thr Phe Val Val Asn Lys Lys Pro Trp Leu Thr Glu Cys 
             420                425                430
Thr Pro Val Tyr Val Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Val 
         435                440                445
Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr 
     450                455                460
Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu 
 465                470                475                480
Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile 
                 485                490                495
Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Arg Met Thr Val Val 
             500                505                510
Gln Ala Tyr Val Gly Asp Val His Tyr Lys Glu Ile Pro Asp Pro Ser 
         515                520                525
Ser Ile Asn Ala Lys Thr Leu Glu Leu Leu Val Asn Ala Ile Ala Ile 
     530                535                540
Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro Pro Glu Lys Glu Gly Ala 
 545                550                555                560
Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Gly Leu Leu Gly Phe 
                 565                570                575
Val Leu Asp Leu Arg Gln Asp Tyr Glu Pro Val Arg Ser Gln Met Pro 
             580                585                590
Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser 
         595                600                605
Met Ser Thr Val Ile Lys Met Pro Asp Glu Ser Phe Arg Met Tyr Ser 
     610                615                620
Lys Gly Ala Ser Glu Ile Val Leu Lys Lys Cys Cys Lys Ile Leu Ser 
 625                630                635                640
Gly Ala Gly Glu Pro Arg Val Phe Arg Pro Arg Asp Arg Asp Glu Met 
                 645                650                655
Val Lys Lys Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile 
             660                665                670
Cys Val Ala Tyr Arg Asp Phe Pro Ser Ser Pro Glu Pro Asp Trp Asp 
         675                680                685
Asn Glu Asn Asp Ile Leu Asn Glu Leu Thr Cys Ile Cys Val Val Gly 
     690                695                700
Ile Glu Asp Pro Val Arg Pro Glu Val Pro Glu Ala Ile Arg Lys Cys 
 705                710                715                720
Gln Arg Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn 
                 725                730                735
Thr Ala Arg Ala Ile Ala Ile Lys Cys Gly Ile Ile His Pro Gly Glu 
             740                745                750
Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Arg Ile Arg Asn 
         755                760                765
Glu Lys Gly Glu Ile Glu Gln Glu Arg Ile Asp Lys Ile Trp Pro Lys 
     770                775                780
Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val 
 785                790                795                800
Lys Gly Ile Ile Asp Ser Thr His Thr Glu Gln Arg Gln Val Val Ala 
                 805                810                815
Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp 
             820                825                830
Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala 
         835                840                845
Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Ser Ser Ile Val Lys Ala 
     850                855                860
Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln 
 865                870                875                880
Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly 
                 885                890                895
Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp 
             900                905                910
Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu 
         915                920                925
Pro Pro Thr Glu Thr Leu Leu Leu Arg Lys Pro Tyr Gly Arg Asn Lys 
     930                935                940
Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Val 
 945                950                955                960
Tyr Gln Leu Thr Leu Ile Phe Thr Leu Leu Phe Val Gly Glu Lys Met 
                 965                970                975
Phe Gln Ile Asp Ser Gly Arg Asn Ala Pro Leu His Ser Pro Pro Ser 
             980                985                990
Glu His Tyr Thr Ile Ile Phe Asn Thr Phe Val Met Met Gln Leu Phe 
         995                1000                1005
Asn Glu Ile Asn Ala Arg Lys Ile His Gly Glu Arg Asn Val Phe Asp 
     1010                1015                1020
Gly Ile Phe Arg Asn Pro Ile Phe Cys Thr Ile Val Leu Gly Thr Phe 
 1025                1030                1035                1040
Ala Ile Gln Ile Val Ile Val Gln Phe Gly Gly Lys Pro Phe Ser Cys 
                 1045                1050                1055
Ser Pro Leu Gln Leu Asp Gln Trp Met Trp Cys Ile Phe Ile Gly Leu 
             1060                1065                1070
Gly Glu Leu Val Trp Gly Gln Val Ile Ala Thr Ile Pro Thr Ser Arg 
         1075                1080                1085
Leu Lys Phe Leu Lys Glu Ala Gly Arg Leu Thr Gln Lys Glu Glu Ile 
     1090                1095                1100
Pro Glu Glu Glu Leu Asn Glu Asp Val Glu Glu Ile Asp His Ala Glu 
 1105                1110                1115                1120
Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg 
                 1125                1130                1135
Ile Gln Thr Gln Ile Arg Val Val Lys Ala Phe Arg Ser Ser Leu Tyr 
             1140                1145                1150
Glu Gly Leu Glu Lys Pro Glu Ser Arg Thr Ser Ile His Asn Phe Met 
         1155                1160                1165
Ala His Pro Glu Phe Arg Ile Glu Asp Ser Gln Pro His Ile Pro Leu 
     1170                1175                1180
Ile Asp Asp Thr Asp Leu Glu Glu Asp Ala Ala Leu Lys Gln Asn Ser 
 1185                1190                1195                1200
Ser Pro Pro Ser Ser Leu Asn Lys Asn Asn Ser Ala Ile Asp Ser Gly 
                 1205                1210                1215
Ile Asn Leu Thr Thr Asp Thr Ser Lys Ser Ala Thr Ser Ser Ser Pro 
             1220                1225                1230
Gly Ser Pro Ile His Ser Leu Glu Thr Ser Leu 
         1235                1240



<210> 2505
<211> 4421
<212> DNA
<213> Homo sapiens
<308> L00620
<400> 2505

gcaaggacc  cagcaaaca  gggtgacat  accaacagc  acttttact  caaaaacca  60
agaaatgag  cgagccatg  gggcgagtt  gggtgcaca  tggaggagc  ccgctccct  120
atggagctg  ggggcactg  ggctgtggt  aagatcaag  agacttatg  ggacaccga  180
gccatctgc  ggcgcctca  aacctcacc  gttgaaggt  tgccgggca  cgctccaga  240
ctggaaaag  gaaagcaaa  ttttgggca  aactttata  ctccaaaga  gccaaaaac  300
ttcctgcag  tcgtgtggg  ggcgctgca  gacgtgacg  tcatcatcc  ggagattgc  360
gccatcatc  ccctggggc  gtccttcta  caccgcccc  gcgagggca  cgaaggatg  420
gcgacggcc  agggtgggg  agaggatga  ggagaggca  aggcaggtt  gatcgaggg  480
gccgccatt  tcctctcag  tatctgtgt  gtcctggtc  cggccttca  tgactggag  540
aaagagaaa  agttccggg  cctgcagag  cgcatcgag  aggaacaga  atttaccgt  600
gtccgggct  gccaggtgg  ccagatccc  gtggctgag  tcgtggttg  ggacatagc  660
caggtcaaa  atggtgacc  cctccctgc  gacggactc  tcatccagg  caatgacct  720
aagattgat  aaagctccc  aactggaga  tctgaccag  tgcgcaagt  cgtggacaa  780
gaccccatg  tgctgtcag  aacccacgt  atggagggc  caggacgga  gttggtgac  840
gctgtgggt  tgaactctc  gactggcat  atctttacc  tcctggggg  tggtggtga  900
gaggaagag  agaaagaca  aaaagccaa  cagcaggac  gggcagccg  catggagat  960
cagcccctc  agagtgccg  gggcggcga  gctgacgac  ggaagaagg  cagcatgca  1020
aagaaggag  agtccgtgc  gcagggcaa  ctcaccaag  tggctgtgc  gatcgggaa  1080
gcgggcttg  tgatgtcag  catcacggt  atcatcctg  tgctctact  cactgtgga  1140
accttcgtg  tcaacaaga  gccgtggct  cctgagtgc  cgcccgtct  cgtgcagta  1200
tttgtcaag  tcttcatca  tggcgtgac  gtgctggtg  tcgccgtgc  cgaggggct  1260
cctctggcc  tcaccatct  gttggccta  tcggtgaag  aaatgatga  ggacaacaa  1320
ctggtacgc  acctggatg  ctgtgagac  atgggcaat  ccacagcca  ctgctcaga  1380
aagacaggc  cgctgacca  caatcgcat  acagtggta  aggcctatg  cgacgacgt  1440
cactataaa  agatccccg  ccccagctc  atcaacacc  agactatgg  gctgctgat  1500
aatgccatc  ccatcaaca  cgcctacac  accaagatt  tgcccccag  gaaggaggg  1560
gccctgcct  ggcaggtgg  caacaagac  gagtgcggc  tgctgggct  cgtgctgga  1620
ctgaagcag  actacgagc  cgtgcgcag  cagatgcca  aggagaagt  gtacaaagt  1680
tacaccttc  actccgtgc  caagtccat  agcactgtc  tcaagctgc  cgacgagag  1740
ttccgcatg  acagcaagg  ggcttctga  atcgtgctc  agaagtgct  caaaatcct  1800
aatggggcg  gagagcctc  tgtcttccg  ccccgcgac  gggacgaga  ggtaaagaa  1860
gtgattgag  ccatggctt  cgatgggct  cgcactatc  gcgtggcct  ccgcgactt  1920
cccagcagc  cggagccgg  ctgggacaa  gagaatgac  tcctcaacg  actcacctg  1980
atctgcgtg  tgggcatcg  ggacccggt  cggccagag  tcccagaag  catccgcaa  2040
tgccagcgg  caggcatca  ggtccgcat  gtcactggc  acaatatca  cacggctcg  2100
gccatcgcc  tcaagtgtg  catcatcca  cctggggag  actttctgt  cctcgaggg  2160
aaggagttc  acaggagga  ccgcaacga  aagggggag  ttgagcagg  gcgaattga  2220
aagatctgg  caaagctgc  ggtgctggc  cgctcctcc  caacggaca  gcataccct  2280
gttaaaggc  tcatcgaca  cacacacac  gagcagcgg  aggtggtgg  cgtgacggg  2340
gacgggacc  acgacgggc  tgcactcaa  aaggccgac  tgggcttcg  catgggcat  2400
gcaggcact  acgtggcca  ggaggcctc  gacatcatc  tgacagacg  caatttcag  2460
agcatcgtc  aggcagtga  gtggggccg  aacgtctat  acagcatct  caaattctt  2520
cagttccag  tcaccgtca  cgtggtggc  gtgattgtg  ccttcacag  cgcctgcat  2580
acgcaggac  cccctctga  ggccgtgca  atgctctgg  tgaacctca  catggacac  2640
tttgcctcg  tggcactgg  cactgagcc  cccacggag  ccctgctgc  gaggaagcc  2700
tacggccgc  acaagccgc  catctccag  accatgatg  agaacatcc  gggccatgc  2760
gtctaccag  ttgccctca  cttcaccct  ctctttgtt  gcgagaaga  gttccagat  2820
gacagcggg  ggaacgcgc  cctgcattc  ccaccctca  aacattaca  catcatctt  2880
aacaccttc  tcatgatgc  gctcttcaa  gagatcaac  cccgcaaga  ccacggcga  2940
cgcaatgtc  ttgacggca  cttccggaa  cccatcttc  gcaccatcg  gctgggcac  3000
tttgccatc  agatagtga  cgtgcagtt  ggagggaag  cattcagct  ctctccact  3060
cagctggac  agtggatgt  gtgcatatt  attgggtta  gagagctcg  ttggggcca  3120
gtcatcgcc  ccatcccga  cagcagact  aagttcctc  aggaggcag  caggctcac  3180
cagaaggag  agatcccgg  ggaggagct  aacgaggac  tggaggaga  cgaccacgc  3240
gagcgggag  tgcggcggg  ccagatcct  tggttccga  gcctgaatc  gatccagac  3300
cagatccgc  tcgtgaagg  gttccgtag  tctctctat  aaggtttag  aaagcctga  3360
tctcgaacc  ccatccata  cttcatggc  catcctgaa  tccggatcg  agattccca  3420
ccccacatc  ccctcattg  tgacaccga  ctggaagaa  atgccgcgc  caagcagaa  3480
tcgagcccg  cgtcatccc  caacaagaa  aacagcgcc  tcgacagtg  gatcaacct  3540
acgaccgac  caagcaaat  agctacctc  tcaagtcca  ggagcccca  ccacagcct  3600
gagacgtcg  tttagctga  gaccctgtc  cctgcccgc  cgccctcat  gaccccgct  3660
tcacccgct  tccgggcac  catccatcc  ggcacccaa  tcacccaag  agcaacgag  3720
aacaatcgg  aaccaaata  tggagagaa  accaacgtt  ccacccaca  accctttct  3780
tggctgcga  gctgtttga  ctctttttc  cttcaaggc  aggggcggg  tctccactg  3840
gggcttacg  gagtgagcg  ttttcccaa  acaagccct  cctggctcc  acccagaca  3900
ggaccagcc  tgcacccgc  cagtcacca  gtcccccgc  tgaatgtac  gtacacttt  3960
aatcctccc  ttgtttggt  tttgggggt  ggggagggg  ttttgtttg  ttgtttgtt  4020
tcttaggcg  gaactgcaa  cagactctt  tctgagact  tttatccaa  ccactggtc  4080
gtgagtttt  gaaacgctt  cacagcatg  tctcagttg  atagattaa  ttaataact  4140
tttgaaatt  cagagctta  ctcgcctag  agatttgca  caatggaac  gaagaactt  4200
atagacact  acaaggtta  atccatttc  ttgtatcta  atcaacgta  acttttccg  4260
gactgtata  gtccatata  ataggtaga  atatatata  atatataaa  atatataca  4320
ggatatata  agtttcttt  ccggcatgt  gccttgttt  cgcttaaat  gctctattt  4380
aacttattt  tgtcctaaa  gaagaatgt  atttgttta  a  4421



<210> 2506
<211> 1243
<212> PRT
<213> Homo sapiens
<308> Q01814
<400> 2506

Met Gly Asp Met Thr Asn Ser Asp Phe Tyr Ser Lys Asn Gln Arg Asn 
  1               5                  10                  15
Glu Ser Ser His Gly Gly Glu Phe Gly Cys Thr Met Glu Glu Leu Arg 
             20                  25                  30
Ser Leu Met Glu Leu Arg Gly Thr Glu Ala Val Val Lys Ile Lys Glu 
         35                  40                  45
Thr Tyr Gly Asp Thr Glu Ala Ile Cys Arg Arg Leu Lys Thr Ser Pro 
     50                  55                  60
Val Glu Gly Leu Pro Gly Thr Ala Pro Asp Leu Glu Lys Arg Lys Gln 
 65                  70                  75                  80
Ile Phe Gly Gln Asn Phe Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu 
                 85                  90                  95
Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu 
             100                105                110
Ile Ala Ala Ile Ile Ser Leu Gly Leu Ser Phe Tyr His Pro Pro Gly 
         115                120                125
Glu Gly Asn Glu Gly Cys Ala Thr Ala Gln Gly Gly Ala Glu Asp Glu 
     130                135                140
Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Leu Ser 
 145                150                155                160
Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu 
                 165                170                175
Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln Lys Phe 
             180                185                190
Thr Val Val Arg Ala Gly Gln Val Val Gln Ile Pro Val Ala Glu Ile 
         195                200                205
Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala 
     210                215                220
Asp Gly Leu Phe Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser 
 225                230                235                240
Leu Thr Gly Glu Ser Asp Gln Val Arg Lys Ser Val Asp Lys Asp Pro 
                 245                250                255
Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Leu 
             260                265                270
Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe Thr Leu 
         275                280                285
Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys Lys Gly Val 
     290                295                300
Lys Lys Gly Asp Gly Leu Gln Leu Pro Ala Ala Asp Gly Ala Ala Ala 
 305                310                315                320
Ser Asn Ala Ala Asp Ser Ala Asn Ala Ser Leu Val Asn Gly Lys Met 
                 325                330                335
Gln Asp Gly Asn Val Asp Ala Ser Gln Ser Lys Ala Lys Gln Gln Asp 
             340                345                350
Gly Ala Ala Ala Met Glu Met Gln Pro Leu Lys Ser Ala Glu Gly Gly 
         355                360                365
Asp Ala Asp Asp Arg Lys Lys Ala Ser Met His Lys Lys Glu Lys Ser 
     370                375                380
Val Leu Gln Gly Lys Leu Thr Lys Leu Ala Val Gln Ile Gly Lys Ala 
 385                390                395                400
Gly Leu Val Met Ser Ala Ile Thr Val Ile Ile Leu Val Leu Tyr Phe 
                 405                410                415
Thr Val Asp Thr Phe Val Val Asn Lys Lys Pro Trp Leu Pro Glu Cys 
             420                425                430
Thr Pro Val Tyr Val Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Val 
         435                440                445
Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr 
     450                455                460
Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu 
 465                470                475                480
Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile 
                 485                490                495
Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Arg Met Thr Val Val 
             500                505                510
Gln Ala Tyr Val Gly Asp Val His Tyr Lys Glu Ile Pro Asp Pro Ser 
         515                520                525
Ser Ile Asn Thr Lys Thr Met Glu Leu Leu Ile Asn Ala Ile Ala Ile 
     530                535                540
Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro Pro Glu Lys Glu Gly Ala 
 545                550                555                560
Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Gly Leu Leu Gly Phe 
                 565                570                575
Val Leu Asp Leu Lys Gln Asp Tyr Glu Pro Val Arg Ser Gln Met Pro 
             580                585                590
Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser 
         595                600                605
Met Ser Thr Val Ile Lys Leu Pro Asp Glu Ser Phe Arg Met Tyr Ser 
     610                615                620
Lys Gly Ala Ser Glu Ile Val Leu Lys Lys Cys Cys Lys Ile Leu Asn 
 625                630                635                640
Gly Ala Gly Glu Pro Arg Val Phe Arg Pro Arg Asp Arg Asp Glu Met 
                 645                650                655
Val Lys Lys Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile 
             660                665                670
Cys Val Ala Tyr Arg Asp Phe Pro Ser Ser Pro Glu Pro Asp Trp Asp 
         675                680                685
Asn Glu Asn Asp Ile Leu Asn Glu Leu Thr Cys Ile Cys Val Val Gly 
     690                695                700
Ile Glu Asp Pro Val Arg Pro Glu Val Pro Glu Ala Ile Arg Lys Cys 
 705                710                715                720
Gln Arg Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn 
                 725                730                735
Thr Ala Arg Ala Ile Ala Ile Lys Cys Gly Ile Ile His Pro Gly Glu 
             740                745                750
Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Arg Ile Arg Asn 
         755                760                765
Glu Lys Gly Glu Ile Glu Gln Glu Arg Ile Asp Lys Ile Trp Pro Lys 
     770                775                780
Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val 
 785                790                795                800
Lys Gly Ile Ile Asp Ser Thr His Thr Glu Gln Arg Gln Val Val Ala 
                 805                810                815
Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp 
             820                825                830
Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala 
         835                840                845
Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Ser Ser Ile Val Lys Ala 
     850                855                860
Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln 
 865                870                875                880
Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly 
                 885                890                895
Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp 
             900                905                910
Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu 
         915                920                925
Pro Pro Thr Glu Thr Leu Leu Leu Arg Lys Pro Tyr Gly Arg Asn Lys 
     930                935                940
Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Val 
 945                950                955                960
Tyr Gln Leu Ala Leu Ile Phe Thr Leu Leu Phe Val Gly Glu Lys Met 
                 965                970                975
Phe Gln Ile Asp Ser Gly Arg Asn Ala Pro Leu His Ser Pro Pro Ser 
             980                985                990
Glu His Tyr Thr Ile Ile Phe Asn Thr Phe Val Met Met Gln Leu Phe 
         995                1000                1005
Asn Glu Ile Asn Ala Arg Lys Ile His Gly Glu Arg Asn Val Phe Asp 
     1010                1015                1020
Gly Ile Phe Arg Asn Pro Ile Phe Cys Thr Ile Val Leu Gly Thr Phe 
 1025                1030                1035                1040
Ala Ile Gln Ile Val Ile Val Gln Phe Gly Gly Lys Pro Phe Ser Cys 
                 1045                1050                1055
Ser Pro Leu Gln Leu Asp Gln Trp Met Trp Cys Ile Phe Ile Gly Leu 
             1060                1065                1070
Gly Glu Leu Val Trp Gly Gln Val Ile Ala Thr Ile Pro Thr Ser Arg 
         1075                1080                1085
Leu Lys Phe Leu Lys Glu Ala Gly Arg Leu Thr Gln Lys Glu Glu Ile 
     1090                1095                1100
Pro Glu Glu Glu Leu Asn Glu Asp Val Glu Glu Ile Asp His Ala Glu 
 1105                1110                1115                1120
Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg 
                 1125                1130                1135
Ile Gln Thr Gln Ile Arg Val Val Lys Ala Phe Arg Ser Ser Leu Tyr 
             1140                1145                1150
Glu Gly Leu Glu Lys Pro Glu Ser Arg Thr Ser Ile His Asn Phe Met 
         1155                1160                1165
Ala His Pro Glu Phe Arg Ile Glu Asp Ser Gln Pro His Ile Pro Leu 
     1170                1175                1180
Ile Asp Asp Thr Asp Leu Glu Glu Asp Ala Ala Leu Lys Gln Asn Ser 
 1185                1190                1195                1200
Ser Pro Pro Ser Ser Leu Asn Lys Asn Asn Ser Ala Ile Asp Ser Gly 
                 1205                1210                1215
Ile Asn Leu Thr Thr Asp Thr Ser Lys Ser Ala Thr Ser Ser Ser Pro 
             1220                1225                1230
Gly Ser Pro Ile His Ser Leu Glu Thr Ser Leu 
         1235                1240



<210> 2507
<211> 1529
<212> DNA
<213> Rattus norvegicus
<308> J03773
<400> 2507

gctgctgcc  gaccatggg  tgtcggcaa  gctcagagg  aaaagaggc  gcgcggcgg  60
cgaggagaa  tgaccgcca  ctgcgctcg  agagccagc  gcagcgccg  gagatcaaa  120
ttctcctgc  gggcaccag  aactcgggc  agagcacca  cgtcaagca  atgaaaatc  180
tccacagcg  tggtttcaa  ctggaggcc  gcaaggagt  caagcccct  atcatctac  240
acgccatcg  ctcgctgac  cgcatcatt  gggccctgg  tgccctgaa  attgatttc  300
acaaccctg  ccgtgccta  gacgccgtg  agctctttg  cctgactgg  ccggcagag  360
gcaagggtg  gatcacgcc  gagctgctg  gtgtcatgc  acggctctg  gctgacccc  420
gggcccagg  ctgcttcgg  cgctccagc  agtaccacc  ggaggacaa  gccgcttac  480
acctgaatg  cctggagcg  atcgcggcg  ccgactata  ccccacggt  gaggacatc  540
tgcgctctc  ggacatgac  acgggcatt  tggaaaaca  gttcacctt  aaggagctt  600
ccttcaaga  ggtggatgt  ggagggcag  ggtcagagc  caaaaaatg  atccactgc  660
ttgagggcg  gacggccat  atcttctgt  tggagctca  tggctatga  ctgaagctt  720
atgaggaca  ccagacgag  cgaatggcg  agagcctgc  tctttttga  tccatctgc  780
acaacaact  gttcatcaa  acctccctc  tcctcttcc  gaacaagaa  gacctcctg  840
cggagaaga  tcggcgtat  ccgctcagc  tctgcttcc  cgagtacaa  ggtcagaac  900
cgtacgagg  agccgcggt  tacatccag  gtcagttcg  ggacctaaa  cgaaacaag  960
agaccaagg  gatctactc  cactttacc  gtgccaccg  caccagtaa  atccagttt  1020
tcttcgacg  agtgacaga  gtcatcata  agaacaatc  caagtacat  ggcctttgc  1080
gaggagccg  gcgcagcct  cttgcctgc  gtgaaaacc  acggggtgt  acaccccac  1140
cctcatgct  gagaggccc  acccagggg  aggaaacgg  gggagtggc  tgaagagtg  1200
gtccccacc  ccagcctct  tcgcctcct  ggccccacg  ctctgcaaa  ataaatata  1260
ttggataga  tgctaggta  gtagacaca  agacacacg  acacgcaca  gcacacgcg  1320
acgcacgtc  ggagacggc  acgctctcc  gcggtcaag  tttcctgaa  ttttcagaa  1380
ctgctgtca  aatttcatt  tgaggccat  ttgcccccc  accccccat  cactctgag  1440
cggcccccg  tctgcacgg  agggagggt  cacgtttga  tgccgagga  gggccggcg  1500
ggctggggc  agggccggc  agctgtgcc  1529



<210> 2508
<211> 354
<212> PRT
<213> Rattus norvegicus
<308> P19627
<400> 2508

Gly Cys Arg Gln Ser Ser Glu Glu Lys Glu Ala Ala Arg Arg Ser Arg 
  1               5                  10                  15
Arg Ile Asp Arg His Leu Arg Ser Glu Ser Gln Arg Gln Arg Arg Glu 
             20                  25                  30
Ile Lys Leu Leu Leu Leu Gly Thr Ser Asn Ser Gly Lys Ser Thr Ile 
         35                  40                  45
Val Lys Gln Met Lys Ile Ile His Ser Gly Gly Phe Asn Leu Glu Ala 
     50                  55                  60
Cys Lys Glu Tyr Lys Pro Leu Ile Ile Tyr Asn Ala Ile Asp Ser Leu 
 65                  70                  75                  80
Thr Arg Ile Ile Arg Ala Leu Ala Ala Leu Lys Ile Asp Phe His Asn 
                 85                  90                  95
Pro Asp Arg Ala Tyr Asp Ala Val Gln Leu Phe Ala Leu Thr Gly Pro 
             100                105                110
Ala Glu Ser Lys Gly Glu Ile Thr Pro Glu Leu Leu Gly Val Met Arg 
         115                120                125
Arg Leu Trp Ala Asp Pro Gly Ala Gln Ala Cys Phe Gly Arg Ser Ser 
     130                135                140
Glu Tyr His Leu Glu Asp Asn Ala Ala Tyr Tyr Leu Asn Asp Leu Glu 
 145                150                155                160
Arg Ile Ala Ala Pro Asp Tyr Ile Pro Thr Val Glu Asp Ile Leu Arg 
                 165                170                175
Ser Arg Asp Met Thr Thr Gly Ile Val Glu Asn Lys Phe Thr Phe Lys 
             180                185                190
Glu Leu Thr Phe Lys Met Val Asp Val Gly Gly Gln Arg Ser Glu Arg 
         195                200                205
Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys 
     210                215                220
Val Glu Leu Ser Gly Tyr Asp Leu Lys Leu Tyr Glu Asp Asn Gln Thr 
 225                230                235                240
Ser Arg Met Ala Glu Ser Leu Arg Leu Phe Asp Ser Ile Cys Asn Asn 
                 245                250                255
Asn Trp Phe Ile Asn Thr Ser Leu Ile Leu Phe Leu Asn Lys Lys Asp 
             260                265                270
Leu Leu Ser Glu Lys Ile Arg Arg Ile Pro Leu Ser Val Cys Phe Pro 
         275                280                285
Glu Tyr Lys Gly Gln Asn Thr Tyr Glu Glu Ala Ala Val Tyr Ile Gln 
     290                295                300
Arg Gln Phe Glu Asp Leu Asn Arg Asn Lys Glu Thr Lys Glu Ile Tyr 
 305                310                315                320
Ser His Phe Thr Cys Ala Thr Asp Thr Ser Asn Ile Gln Phe Val Phe 
                 325                330                335
Asp Ala Val Thr Asp Val Ile Ile Gln Asn Asn Leu Lys Tyr Ile Gly 
             340                345                350
Leu Cys 
         355



<210> 2509
<211> 2679
<212> DNA
<213> Homo sapiens
<308> J03260
<400> 2509

gagaccagg  ccatgggat  tcggcaaag  tcagaggaa  aagaagcag  ccggcggtc  60
cggagaatt  accgccacc  gcgctcaga  agccagcgg  aacgccgcg  aatcaagct  120
ctcctgctg  gcaccagca  ctcaggcaa  agcaccatc  tcaaacaga  gaagatcat  180
cacagcggc  gcttcaacc  ggaggcctg  aaggagtac  agcccctca  catctacaa  240
gccatcgac  cgctgaccc  catcatccg  gccctggcc  ccctcagga  cgacttcca  300
aaccccgac  gcgcctacg  cgctgtgca  ctctttgcg  tgacgggcc  cgctgagag  360
aagggcgag  tcacacccg  gctgctggg  gtcatgcga  ggctctggg  cgacccagg  420
gcacaggcc  gcttcagcc  ctccagcga  taccacctg  aggacaacg  ggcctacta  480
ctgaacgac  tggagcgca  cgccgcagc  gactatatc  ccactgtcg  ggacatcct  540
cgctcccgg  acatgacca  gggcattgt  gagaacaag  tcaccttca  ggagctcac  600
ttcaagatg  tggacgtgg  ggggcagag  tcagagcgc  aaaagtgga  ccactgctt  660
gagggcgtc  cagccatca  cttctgtgt  gagctcagc  gctacgacc  gaaactcta  720
gaggataac  agacaagtc  gatggcaga  agcttgcgc  tctttgact  catctgcaa  780
aacaactgg  tcatcaaca  ctcactcat  ctcttcctg  acaagaagg  cctgctggc  840
gagaagatc  gccgcatcc  gctcaccat  tgctttccc  agtacaagg  ccagaacac  900
tacgaggag  ccgctgtct  catccagcg  cagtttgaa  acctgaacc  caacaagga  960
accaaggag  tctactccc  cttcacctg  gccaccgac  ccagtaaca  ccagtttgt  1020
ttcgacgcg  tgacagacg  catcataca  aacaatctc  agtacattg  cctttgctg  1080
ggagctggg  ccggggcgc  tgcctatgg  gaaacccac  gggtgtcat  ccccaacgc  1140
tgctagaga  gcccaatcc  ggggcagaa  acagggggc  taaagaatg  cccccaccc  1200
ttggcctct  cctccttgg  cccacattt  tgcaaacat  aatatttac  gatagattg  1260
taggtagat  gacacacac  catgcacac  cacacatct  gagatggca  aatcctcta  1320
aatgtcgag  tctcttgaa  acttgagaa  ctgtcacaa  gtcactaca  gcccaacct  1380
ccccttcac  ttgccttcc  gagttggcc  cactccact  gggggtctg  attggattg  1440
tagggatag  cagcagggc  gaggcaagg  aggccaact  cacccctgt  acctggagg  1500
gggccggct  gctgcccga  ctctggcct  gggaccttg  cgctgacca  gagggagga  1560
cagtgcagg  tctgtgcac  ttccctgct  gcctgcaca  agctgctca  caccatttc  1620
ttctggacc  gggacctta  gagccgggt  acagcacta  ccagacctc  agccactca  1680
agctctttt  aaaaaacag  ttcaaaata  gcagcaaaa  ccaatacaa  aaaacgagt  1740
gcacgattt  tttcaaact  ggccagctg  gattccagc  tttcttcta  tagtctgat  1800
ttttataaa  caaaacctg  ttttccttc  ctggcattt  tttttgttt  ttgtttttt  1860
gtttttttt  tttttttgg  caaatctcg  ggtgtttcg  agaaaaaaa  ccagaaaat  1920
tcaaatgca  ttgagtatt  ttttttaaa  gcagatttt  aaaacatat  ttttttcag  1980
tggtctttt  tgtgtctgg  ttgctgagt  taaaagttg  tatctggac  atctgtctc  2040
ctgctccaa  gaaattttg  agtgagtgg  agtcctgcg  cagcctcgc  ggacacgtg  2100
tgtacataa  cctctgcag  gtcctcttg  taatggtgg  gttttctgc  ttgttttta  2160
ttaagaaaa  aaacacgac  tatttaaag  aggttcttt  acctgggag  aaatgaaca  2220
tagctaagt  tcttggtat  taaagagta  attatttgt  gctttgctg  gtgaaggaa  2280
gggagcaag  ggtggtgcc  ctggtccca  catgccccg  gcctgagac  ggctggaaa  2340
gctctgact  ctgtgaagg  acagccagc  ttgtggcct  agggaggcc  tgctgggac  2400
ctgatctgg  ccttcctgt  ccagggcct  tgggcaact  cgttgaaag  acgttcgcc  2460
agggccgtg  gtaaatacg  actgcgcca  ggagaggag  ggcactgcc  gagcccttg  2520
cagatctcc  tccctctct  tgtgcagta  ctgtgtgtc  gaggtcagt  tgcggaatc  2580
cagccaagg  cgtgaagag  tgtacgggg  aaagagaag  tggggattg  atgaaagtc  2640
aaggttgtc  actttaaga  aataaaata  cctgaatgg  2679



<210> 2510
<211> 354
<212> PRT
<213> Homo sapiens
<308> P19086
<400> 2510

Gly Cys Arg Gln Ser Ser Glu Glu Lys Glu Ala Ala Arg Arg Ser Arg 
  1               5                  10                  15
Arg Ile Asp Arg His Leu Arg Ser Glu Ser Gln Arg Gln Arg Arg Glu 
             20                  25                  30
Ile Lys Leu Leu Leu Leu Gly Thr Ser Asn Ser Gly Lys Ser Thr Ile 
         35                  40                  45
Val Lys Gln Met Lys Ile Ile His Ser Gly Gly Phe Asn Leu Glu Ala 
     50                  55                  60
Cys Lys Glu Tyr Lys Pro Leu Ile Ile Tyr Asn Ala Ile Asp Ser Leu 
 65                  70                  75                  80
Thr Arg Ile Ile Arg Ala Leu Ala Ala Leu Arg Ile Asp Phe His Asn 
                 85                  90                  95
Pro Asp Arg Ala Tyr Asp Ala Val Gln Leu Phe Ala Leu Thr Gly Pro 
             100                105                110
Ala Glu Ser Lys Gly Glu Ile Thr Pro Glu Leu Leu Gly Val Met Arg 
         115                120                125
Arg Leu Trp Ala Asp Pro Gly Ala Gln Ala Cys Phe Ser Arg Ser Ser 
     130                135                140
Glu Tyr His Leu Glu Asp Asn Ala Ala Tyr Tyr Leu Asn Asp Leu Glu 
 145                150                155                160
Arg Ile Ala Ala Ala Asp Tyr Ile Pro Thr Val Glu Asp Ile Leu Arg 
                 165                170                175
Ser Arg Asp Met Thr Thr Gly Ile Val Glu Asn Lys Phe Thr Phe Lys 
             180                185                190
Glu Leu Thr Phe Lys Met Val Asp Val Gly Gly Gln Arg Ser Glu Arg 
         195                200                205
Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys 
     210                215                220
Val Glu Leu Ser Gly Tyr Asp Leu Lys Leu Tyr Glu Asp Asn Gln Thr 
 225                230                235                240
Ser Arg Met Ala Glu Ser Leu Arg Leu Phe Asp Ser Ile Cys Asn Asn 
                 245                250                255
Asn Trp Phe Ile Asn Thr Ser Leu Ile Leu Phe Leu Asn Lys Lys Asp 
             260                265                270
Leu Leu Ala Glu Lys Ile Arg Arg Ile Pro Leu Thr Ile Cys Phe Pro 
         275                280                285
Glu Tyr Lys Gly Gln Asn Thr Tyr Glu Glu Ala Ala Val Tyr Ile Gln 
     290                295                300
Arg Gln Phe Glu Asp Leu Asn Arg Asn Lys Glu Thr Lys Glu Ile Tyr 
 305                310                315                320
Ser His Phe Thr Cys Ala Thr Asp Thr Ser Asn Ile Gln Phe Val Phe 
                 325                330                335
Asp Ala Val Thr Asp Val Ile Ile Gln Asn Asn Leu Lys Tyr Ile Gly 
             340                345                350
Leu Cys 
         355



<210> 2511
<211> 1348
<212> DNA
<213> Rattus norvegicus
<308> J03867
<400> 2511

tagaacggt  ccaccactg  cttcttcgc  accatgggg  cccagctga  cacgttgag  60
cgagtggta  tctccccgg  ctggttcgt  tacagcctc  tcatgaagc  gtttcagcg  120
tcctcaccg  ccatcaccc  cgagaaccc  gacatcaag  accctctgc  gctcatcga  180
aaggagatt  tcagccatg  cactcggcg  ttccgattt  cactccctt  gccccagca  240
atcctgggc  ttcctatcg  ccagcacat  tacctctcc  ccaggatcg  tggcaactt  300
gtcattcgt  cctacaccc  tgtgtctag  gatgatgac  agggccttg  ggacttggt  360
gtcaaggtt  acttcaagg  cacgcatcc  aagtttcca  ctggaggga  aatgtctca  420
tacctggaa  acatgaata  tggagacac  attgaattc  ggggcccca  tgggctact  480
gtctaccag  gcaaaggga  gttcgccat  cgtgcagac  agaagtcca  ccctgttgt  540
aggacggtg  agtctgtag  catgattgc  ggagggaca  gcatcaccc  aatgctgca  600
gtgatccga  ccgtcttga  ggacccgaa  gaccacact  tgtgctatc  gctcttcgc  660
aaccagtcc  agaaagaca  cctgctgcg  cctgagctg  aggaactga  gaacgaaca  720
tcttctcgc  tcaagctct  gtacacagt  gacaaagcc  ccgatgcct  ggactatag  780
caaggcttc  tgaatgagg  gatgatcag  gaccatctt  cacctcctg  ggaggagac  840
ctgatactg  tgtgtggac  cccaccgat  atccagttt  cctgtttgc  aaacctgga  900
cgtgtgggc  atcccaagg  gcgatgctt  accttctga  ggctggatg  tggccactc  960
catgcctgc  gctcacgca  tcaccacaa  caccttcca  cccttcctt  cccactact  1020
tcctttacc  tgacatatg  ccacatcca  gctggggcc  gggttcagc  tggcctgcc  1080
agccctggt  atccagctg  actggcccc  gaggggccc  tttgggagc  ggcctgtgt  1140
tcaggtggc  tctgttgac  actttctga  taggcttct  tctggtact  actggccat  1200
accagagat  gtccatgac  accccttta  acacacaca  atacacata  agagacaga  1260
agacagaga  acagagata  acagagata  acagagaga  agatacaga  atagagaca  1320
agagagaag  gagagagag  agagagag  1348



<210> 2512
<211> 300
<212> PRT
<213> Rattus norvegicus
<308> P20070
<400> 2512

Gly Ala Gln Leu Ser Thr Leu Ser Arg Val Val Leu Ser Pro Val Trp 
  1               5                  10                  15
Phe Val Tyr Ser Leu Phe Met Lys Leu Phe Gln Arg Ser Ser Pro Ala 
             20                  25                  30
Ile Thr Leu Glu Asn Pro Asp Ile Lys Tyr Pro Leu Arg Leu Ile Asp 
         35                  40                  45
Lys Glu Ile Ile Ser His Asp Thr Arg Arg Phe Arg Phe Ala Leu Pro 
     50                  55                  60
Ser Pro Gln His Ile Leu Gly Leu Pro Ile Gly Gln His Ile Tyr Leu 
 65                  70                  75                  80
Ser Thr Arg Ile Asp Gly Asn Leu Val Ile Arg Pro Tyr Thr Pro Val 
                 85                  90                  95
Ser Ser Asp Asp Asp Lys Gly Phe Val Asp Leu Val Val Lys Val Tyr 
             100                105                110
Phe Lys Asp Thr His Pro Lys Phe Pro Ala Gly Gly Lys Met Ser Gln 
         115                120                125
Tyr Leu Glu Asn Met Asn Ile Gly Asp Thr Ile Glu Phe Arg Gly Pro 
     130                135                140
Asn Gly Leu Leu Val Tyr Gln Gly Lys Gly Lys Phe Ala Ile Arg Ala 
 145                150                155                160
Asp Lys Lys Ser Asn Pro Val Val Arg Thr Val Lys Ser Val Gly Met 
                 165                170                175
Ile Ala Gly Gly Thr Gly Ile Thr Pro Met Leu Gln Val Ile Arg Ala 
             180                185                190
Val Leu Lys Asp Pro Asn Asp His Thr Val Cys Tyr Leu Leu Phe Ala 
         195                200                205
Asn Gln Ser Glu Lys Asp Ile Leu Leu Arg Pro Glu Leu Glu Glu Leu 
     210                215                220
Arg Asn Glu His Ser Ser Arg Phe Lys Leu Trp Tyr Thr Val Asp Lys 
 225                230                235                240
Ala Pro Asp Ala Trp Asp Tyr Ser Gln Gly Phe Val Asn Glu Glu Met 
                 245                250                255
Ile Arg Asp His Leu Pro Pro Pro Gly Glu Glu Thr Leu Ile Leu Met 
             260                265                270
Cys Gly Pro Pro Pro Met Ile Gln Phe Ala Cys Leu Pro Asn Leu Glu 
         275                280                285
Arg Val Gly His Pro Lys Glu Arg Cys Phe Thr Phe 
     290                295                300



<210> 2513
<211> 1783
<212> DNA
<213> Homo sapiens
<308> M16462
<400> 2513

cggtggccc  gcgccgcgc  cgctctcga  agcccggac  tcaagtacc  gctgcggct  60
atcgaccgg  agatcatca  ccatgacac  cggcgcttc  gctttgccc  gccgccacc  120
cagcacatc  tgggcctcc  tgtcggcca  cacatctac  tctcggctc  aattgatgg  180
aacctggtc  tccggccct  tacaccaat  tccagcgat  atgacaagg  cttcgtgga  240
ctggtcatc  aggtttact  caaggacac  catcccaag  ttcccgctg  agggaagat  300
tctcagtac  tggagagca  gcagattgg  gacaccatt  agttccggg  ccccagtgg  360
ctgctggtc  accagggca  agggaagtt  gccatccga  ctgacaaaa  gtccaaccc  420
atcatcagg  cagtgaagt  tgtgggcat  atcgcggga  ggacaggca  caccccgat  480
ctgcaggtg  tccgcgcca  catgaagga  cctgatgac  acactgtgt  ccacctgct  540
tttgccaac  agaccgaga  ggacatcct  ctgcgacct  agctggagg  actcaggaa  600
aaacattct  cacgcttca  gctctggta  acgctggac  gagcccctg  agcctggga  660
tacggccag  gcttcgtga  tgaggagat  atccgggac  accttccac  cccagagga  720
gagccgctg  tgctgatgt  tggcccccc  cccatgatc  agtacgcct  ccttcccaa  780
ctggaccac  tgggccacc  cacggagcg  tgcttcgtc  tctgagggc  gggcaccgg  840
cacacggcc  ccgcccccg  gcaccccac  ccctgttca  gctcaccca  tcacctccc  900
acatcgcac  ctggggccc  gggttcagc  tggcctgcc  gtgccctgg  gaatcacct  960
gctgagcag  tcccctgga  ccccttcgg  agcagggct  tgtcccaga  gggccacgg  1020
tgagccttc  gagtacgtc  tgcctggca  ttactggtc  ttaccagag  cgcccagcc  1080
catccctgt  ctcatgacc  ctcgtccac  ccccacaca  actataagg  tgagggctg  1140
cagcagccc  gtctgccca  cattcccgg  cgtggacca  agtcgggat  tcagcagac  1200
cacatggca  gcccaaagc  gcaggtccc  gggcccacc  cagccacgc  tgtcacccc  1260
actcccgcc  cagggccag  cccaggcct  accacctga  gctgcatga  acattgaca  1320
cagaaagcc  tcttggggg  actgctccc  accccaggg  cctggccag  cgggagctt  1380
gctctcctc  ggctagagt  ggaagaggg  gctggccat  gggccctcc  agaacctca  1440
catttcctt  cagcccatc  aaacactga  gcagccttg  ggaaccccg  gctgggggg  1500
tggcagccc  ctgcaccgc  tcagggttt  ggggtcctg  gctggggcc  catccctga  1560
ggcagaact  ccacaacca  atgtattta  tcctctgtc  taaaccgtc  cctccttcc  1620
tcaccccca  cacaggggg  ttctgagca  tgcctcttg  ctgagggac  tatcagtga  1680
ctcgacgtt  cctttagac  acagttgtg  tagcctctt  cgtattggc  ttttcagag  1740
catttatga  cagaaaaaa  aaaagtaaa  ctttgctaa  att  1783



<210> 2514
<211> 300
<212> PRT
<213> Homo sapiens
<308> P00387
<400> 2514

Gly Ala Gln Leu Ser Thr Leu Gly His Met Val Leu Phe Pro Val Trp 
  1               5                  10                  15
Phe Leu Tyr Ser Leu Leu Met Lys Leu Phe Gln Arg Ser Thr Pro Ala 
             20                  25                  30
Ile Thr Leu Glu Ser Pro Asp Ile Lys Tyr Pro Leu Arg Leu Ile Asp 
         35                  40                  45
Arg Glu Ile Ile Ser His Asp Thr Arg Arg Phe Arg Phe Ala Leu Pro 
     50                  55                  60
Ser Pro Gln His Ile Leu Gly Leu Pro Val Gly Gln His Ile Tyr Leu 
 65                  70                  75                  80
Ser Ala Arg Ile Asp Gly Asn Leu Val Val Arg Pro Tyr Thr Pro Ile 
                 85                  90                  95
Ser Ser Asp Asp Asp Lys Gly Phe Val Asp Leu Val Ile Lys Val Tyr 
             100                105                110
Phe Lys Asp Thr His Pro Lys Phe Pro Ala Gly Gly Lys Met Ser Gln 
         115                120                125
Tyr Leu Glu Ser Met Gln Ile Gly Asp Thr Ile Glu Phe Arg Gly Pro 
     130                135                140
Ser Gly Leu Leu Val Tyr Gln Gly Lys Gly Lys Phe Ala Ile Arg Pro 
 145                150                155                160
Asp Lys Lys Ser Asn Pro Ile Ile Arg Thr Val Lys Ser Val Gly Met 
                 165                170                175
Ile Ala Gly Gly Thr Gly Ile Thr Pro Met Leu Gln Val Ile Arg Ala 
             180                185                190
Ile Met Lys Asp Pro Asp Asp His Thr Val Cys His Leu Leu Phe Ala 
         195                200                205
Asn Gln Thr Glu Lys Asp Ile Leu Leu Arg Pro Glu Leu Glu Glu Leu 
     210                215                220
Arg Asn Lys His Ser Ala Arg Phe Lys Leu Trp Tyr Thr Leu Asp Arg 
 225                230                235                240
Ala Pro Glu Ala Trp Asp Tyr Gly Gln Gly Phe Val Asn Glu Glu Met 
                 245                250                255
Ile Arg Asp His Leu Pro Pro Pro Glu Glu Glu Pro Leu Val Leu Met 
             260                265                270
Cys Gly Pro Pro Pro Met Ile Gln Tyr Ala Cys Leu Pro Asn Leu Asp 
         275                280                285
His Val Gly His Pro Thr Glu Arg Cys Phe Val Phe 
     290                295                300



<210> 2515
<211> 2799
<212> DNA
<213> Rattus norvegicus
<308> J03886
<400> 2515

ggtcgacca  ctagaacgc  ttgagttca  acacgcaga  gcacacgcc  acctacctc  60
tggctacag  aaacggagc  gttgagctg  gaacccaga  tctgtcaac  gaccaccca  120
ctacagacg  agcaggtga  ggatctcca  cttcagaga  agaacccag  ctcccagac  180
cagagaaag  cctgggccc  actaacacg  agaaagacc  tggcgcgcc  gatccaaag  240
aaaatccag  tccaccctc  ctgaagaaa  ctcccgaag  ccctggtcc  gagaaaaag  300
gtgactcgg  cccagcttc  gccagcaac  agggccctt  aggagaggg  gatggaggt  360
ggggccctg  tgaaggcgg  acggggcct  ctgcagtct  gccccagcc  actgccaca  420
ctgatgcca  catccagaa  ctggacgcc  cgcaagcgc  ctcgggcaa  caggaatct  480
gagaggcca  ggcaggcaa  aaggcagca  aatgccgag  agcaggacg  aggggctca  540
ccgcctttc  tcacagccc  agctgcccc  cgatcatct  ctgttctga  aagacactg  600
ccatgaagc  cttaagcga  acaacagag  tcatctttg  aggggtgtc  gaaacccct  660
atccccaag  tcctggtcc  gctaaggac  aaggaggga  gaacacgct  gcagacggg  720
aagaagagg  agaggcagg  caggctgag  aggctaagg  gcaagggga  acctcccag  780
ggatcgggt  ccaggctgt  ccctcagag  gagcagagg  ggggcaggc  ctctgtctc  840
cggccaagg  ggaagactg  ttccaaatt  tggatgatt  tccaccacc  ccagccccc  900
tcccacaca  gatcgtgga  ctgaggacc  gaaatgtca  cagtgaatt  agcatgaac  960
caaaggagg  attgggagg  ggcaagttt  gagctgtgt  cacctgcac  gagagatcc  1020
caggcctca  gctggcagc  aaggtcatc  agaaacaga  ccccaagga  aaggaaatg  1080
tgttgctgg  gatcgaggt  atgaaccag  tgaaccacc  caatttgat  cagctgtac  1140
cagccattg  gacctctca  gagatcatc  tgttcatgg  gtacattga  ggcggcgag  1200
tctttgaga  gatcgtgga  gaggactac  aactgacgg  agtggatac  atggtgttc  1260
tcaggcaga  ctgcgacgg  atcctcttc  tgcacaaga  gagggtcct  cacttggac  1320
tcaagccag  gaacatcct  tgtgtgaat  ccaccgggc  cttggtgaa  ataattgac  1380
tcggcctgg  aagaaggta  aaccccaat  agaagctga  ggtgaattt  gggaccccg  1440
agttcctgt  accagaggt  gtgaactat  accagatct  tgacaagac  gacatgtgg  1500
gtcttgggg  gatcaccta  atgctactg  gtggcctct  tcccttcct  ggcgacgat  1560
acacggaga  cctaaacaa  gtcctgtct  ccaactggt  ctttgatga  gagactttt  1620
aagctgtgt  agacgaggc  aaagacttc  tttccaatc  tatcacgaa  gaccagagt  1680
ccagaatga  tgctgagca  tgcctcgcc  acccctggc  caacaacct  gcagaaaaa  1740
ccaagcgct  caaccgtcg  ctcaagtcc  agatcctgc  taagaaata  ctcatgaag  1800
ggcgctgga  gaaaaactt  attgctgtc  gcgcacgca  tcgcttcaa  aagatcagt  1860
gctcggggg  actgatggc  ttgggggtc  gaaccccag  cgactaaaa  cctggatgc  1920
ctcgcatgg  caaggctga  accagagag  gccggccag  tctctagag  aggctggtc  1980
ggacaaatc  gcaccaggc  cagaggctt  gggctccgc  ggtccttag  cttaccgct  2040
cccctacgt  aacatggag  gtggcctgg  atccatctg  gaccgcctc  tcagcaggc  2100
gtgtgaccg  ttcccccta  gtgaacatg  agtgtggcc  ggaatccac  ctgtgaccg  2160
ctcctcagc  ggctgtgcc  gtcagcccc  ccagactcc  aggacagcc  ggccaggcc  2220
ttcctagtc  ctccctagc  tgccccttt  aactgctgc  ccgtaacct  tttttcctg  2280
acctggggc  ctcttgccc  ggagcggga  ggccggggg  ccagcaggt  ggctgctgt  2340
gtggtggtg  tggatggga  attctagga  ggtagaaat  cagtcagct  caggggaga  2400
agagcaggc  ttgtgtgag  ggacctcca  gccctgcct  acactccca  cagatacaa  2460
cttgcacac  ccatctggc  cctggctcc  accttctgt  tgtgaccac  aacacatag  2520
aacttgtga  agaaagcca  cccaggcct  gagaggtgg  ggtggtagc  gagagaagt  2580
tgggaggcc  gagaaccac  cccctaagt  tacttgagg  ccgagtctt  catcctggc  2640
actctgtac  catcccagg  gcatctgaa  accccaaat  acaggatga  ctggccaca  2700
ggagtatga  agccgtcgg  gcagacccc  aaccgctct  agcttgtgc  ttataaata  2760
acacacagg  tggaggcag  ctccttcct  tgcgcatgc  2799



<210> 2516
<211> 609
<212> PRT
<213> Rattus norvegicus
<308> P20689
<400> 2516

Ala Thr Glu Asn Gly Ala Val Glu Leu Gly Thr Gln Ser Leu Ser Thr 
  1               5                  10                  15
Asp His Pro Pro Thr Asp Ala Ala Gly Asp Gly Ser Pro Ala Ser Glu 
             20                  25                  30
Lys Glu Pro Ser Leu Pro Asp Thr Glu Lys Asp Leu Gly Pro Thr Asn 
         35                  40                  45
Thr Lys Lys Asp Pro Gly Ala Pro Asp Pro Lys Lys Asn Pro Asp Pro 
     50                  55                  60
Pro Ser Leu Lys Lys Thr Pro Glu Ala Pro Gly Pro Glu Lys Lys Gly 
 65                  70                  75                  80
Asp Ser Ala Pro Ala Ser Ala Ser Asn Gln Gly Pro Ser Gly Glu Gly 
                 85                  90                  95
Asp Gly Gly Gly Gly Pro Ala Glu Gly Gly Thr Gly Pro Pro Ala Val 
             100                105                110
Leu Pro Gln Pro Thr Ala Thr Ala Asp Ala Ser Ile Gln Lys Leu Asp 
         115                120                125
Ala Thr Gln Ala Pro Ser Gly Asn Gln Glu Ser Gly Glu Ala Lys Ala 
     130                135                140
Gly Lys Lys Ala Ala Glu Cys Arg Glu Ala Gly Arg Arg Gly Ser Pro 
 145                150                155                160
Ala Phe Leu His Ser Pro Ser Cys Pro Ala Ile Ile Ser Cys Ser Glu 
                 165                170                175
Lys Thr Leu Ala Met Lys Pro Leu Ser Glu Thr Thr Glu Leu Ile Phe 
             180                185                190
Ala Gly Val Ser Glu Thr Pro Asp Pro Gln Asp Pro Gly Pro Ala Lys 
         195                200                205
Asp Glu Gly Gly Thr Asn Thr Leu Ala Asp Gly Lys Glu Glu Ala Glu 
     210                215                220
Ala Gly Gln Ala Glu Gln Ala Lys Val Gln Gly Asp Thr Ser Gln Arg 
 225                230                235                240
Ile Gly Phe Gln Ala Val Pro Ser Glu Arg Ala Glu Val Gly Gln Ala 
                 245                250                255
Leu Cys Leu Thr Ala Lys Glu Glu Asp Cys Phe Gln Ile Leu Asp Asp 
             260                265                270
Cys Pro Pro Pro Pro Ala Pro Phe Pro His Arg Ile Val Glu Leu Arg 
         275                280                285
Thr Gly Asn Val Ser Ser Glu Phe Ser Met Asn Ser Lys Glu Ala Leu 
     290                295                300
Gly Gly Gly Lys Phe Gly Ala Val Cys Thr Cys Thr Glu Arg Ser Thr 
 305                310                315                320
Gly Leu Lys Leu Ala Ala Lys Val Ile Lys Lys Gln Thr Pro Lys Asp 
                 325                330                335
Lys Glu Met Val Leu Leu Glu Ile Glu Val Met Asn Gln Leu Asn His 
             340                345                350
Arg Asn Leu Ile Gln Leu Tyr Ser Ala Ile Glu Thr Ser His Glu Ile 
         355                360                365
Ile Leu Phe Met Glu Tyr Ile Glu Gly Gly Glu Leu Phe Glu Arg Ile 
     370                375                380
Val Asp Glu Asp Tyr Gln Leu Thr Glu Val Asp Thr Met Val Phe Val 
 385                390                395                400
Arg Gln Ile Cys Asp Gly Ile Leu Phe Met His Lys Met Arg Val Leu 
                 405                410                415
His Leu Asp Leu Lys Pro Glu Asn Ile Leu Cys Val Asn Thr Thr Gly 
             420                425                430
His Leu Val Lys Ile Ile Asp Phe Gly Leu Ala Arg Arg Tyr Asn Pro 
         435                440                445
Asn Glu Lys Leu Lys Val Asn Phe Gly Thr Pro Glu Phe Leu Ser Pro 
     450                455                460
Glu Val Val Asn Tyr Asp Gln Ile Ser Asp Lys Thr Asp Met Trp Ser 
 465                470                475                480
Leu Gly Val Ile Thr Tyr Met Leu Leu Ser Gly Leu Ser Pro Phe Leu 
                 485                490                495
Gly Asp Asp Asp Thr Glu Thr Leu Asn Asn Val Leu Ser Ala Asn Trp 
             500                505                510
Tyr Phe Asp Glu Glu Thr Phe Glu Ala Val Ser Asp Glu Ala Lys Asp 
         515                520                525
Phe Val Ser Asn Leu Ile Thr Lys Asp Gln Ser Ala Arg Met Ser Ala 
     530                535                540
Glu Gln Cys Leu Ala His Pro Trp Leu Asn Asn Leu Ala Glu Lys Ala 
 545                550                555                560
Lys Arg Cys Asn Arg Arg Leu Lys Ser Gln Ile Leu Leu Lys Lys Tyr 
                 565                570                575
Leu Met Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala 
             580                585                590
Asn Arg Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu Met Ala Leu Gly 
         595                600                605
Val 
     610



<210> 2517
<211> 1658
<212> DNA
<213> Homo sapiens
<308> BC007753
<400> 2517

ggaggggtc  gtgcacaca  catcgaggg  ggagagctc  tcgagagga  tgtggatga  60
gactaccat  tgaccgagg  ggacaccat  gtgtttgtc  ggcagatct  tgacgggat  120
ctcttcatg  acaagatga  ggttttgca  ctggacctc  agccagaga  catcctgtg  180
gtcaacacc  ccgggcatt  ggtgaagat  attgacttt  gcctggcac  gaggtataa  240
cccaacgag  agctgaagg  gaactttgg  accccagag  tcctgtcac  tgaggtggt  300
aattatgac  aaatctccg  taagacaga  atgtggagt  tgggggtga  cacctacat  360
ctgctgagc  gcctctccc  cttcctggg  gatgatgac  cagagaccc  aaacaacgt  420
ctatctggc  actggtact  tgatgaaga  acctttgag  ccgtatcag  cgaggccaa  480
gactttgtc  ccaacctca  cgtcaagga  cagagggcc  ggatgaacg  tgcccagtg  540
ctcgcccat  cctggctca  caacctggc  gagaaagcc  aacgctgta  ccgacgcct  600
aagtcccag  tcttgctta  gaaatacct  atgaagagg  gctggaaga  aaacttcat  660
gctgtcagc  ctgccaacc  cttcaagaa  atcagcagc  cgggggcac  gatggctct  720
ggggtctga  ccctgggcg  agctgaagc  tggacgcag  cacacagtg  ccggggctg  780
agccacaca  cccagaagg  cagaaaagg  agccagatc  ccagggcag  ctcgttagg  840
caaggctgt  ccaggctgg  aggctcggg  ctccccacg  ccccatgca  tgaccgctt  900
cccgatgtg  gccgcctcg  agtgtggcc  ggatccatc  tgctagcac  tccccagac  960
gggctccag  ctgtcggcc  caccccaga  tccaggccc  cgttgaagc  gctcccggt  1020
ccctcccca  ctcctcgtc  ttgaactgc  gccgccgtg  tgacccctg  tttgcccca  1080
tgggagagt  cttagcctg  gcctcctcc  agctggagt  ccatggctg  ggggtctca  1140
catgtaggg  ttctgtggt  gtggatggg  ggctcctgg  ggggcagaa  ggctgcaac  1200
ctgattcct  aggcccagc  gccagggaa  acagagcag  ctttgtgag  gaggacctc  1260
atgcccccg  cacctcccc  ctccagcag  taaggccga  cccacacca  ctggtccag  1320
ctggccccc  cccaccttc  ttgcgacca  caacacaca  gaactctgt  tgagagaga  1380
ggcgcccag  ccaggcctg  tggaggggg  ggggagaag  caagggaca  aggagacca  1440
ccccgagct  gcctcaggg  caagccggc  caacccaac  actcggggc  cccatcttg  1500
gggtcaccc  tggcctcag  tgatggggt  agcaggccc  ggagaatta  gaaggccat  1560
gggcagcct  cagtctgct  tcagcttgt  ccttgtaaa  aaatgtaca  gttggatgt  1620
gaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  1658



<210> 2518
<211> 596
<212> PRT
<213> Homo sapiens
<308> NP_149109
<400> 2518

Met Ala Thr Glu Asn Gly Ala Val Glu Leu Gly Ile Gln Asn Pro Ser 
  1               5                  10                  15
Thr Asp Lys Ala Pro Lys Gly Pro Thr Gly Glu Arg Pro Leu Ala Ala 
             20                  25                  30
Gly Lys Asp Pro Gly Pro Pro Asp Pro Lys Lys Ala Pro Asp Pro Pro 
         35                  40                  45
Thr Leu Lys Lys Asp Ala Lys Ala Pro Ala Ser Glu Lys Gly Asp Gly 
     50                  55                  60
Thr Leu Ala Gln Pro Ser Thr Ser Ser Gln Gly Pro Lys Gly Glu Gly 
 65                  70                  75                  80
Asp Arg Gly Gly Gly Pro Ala Glu Gly Ser Ala Gly Pro Pro Ala Ala 
                 85                  90                  95
Leu Pro Gln Gln Thr Ala Thr Pro Glu Thr Ser Val Lys Lys Pro Lys 
             100                105                110
Ala Glu Gln Gly Ala Ser Gly Ser Gln Asp Pro Gly Lys Pro Arg Val 
         115                120                125
Gly Lys Lys Ala Ala Glu Gly Gln Ala Ala Ala Arg Arg Gly Ser Pro 
     130                135                140
Ala Phe Leu His Ser Pro Ser Cys Pro Ala Ile Ile Ser Ser Ser Glu 
 145                150                155                160
Lys Leu Leu Ala Lys Lys Pro Pro Ser Glu Ala Ser Glu Leu Thr Phe 
                 165                170                175
Glu Gly Val Pro Met Thr His Ser Pro Thr Asp Pro Arg Pro Ala Lys 
             180                185                190
Ala Glu Glu Gly Lys Asn Ile Leu Ala Glu Ser Gln Lys Glu Val Gly 
         195                200                205
Glu Lys Thr Pro Gly Gln Ala Gly Gln Ala Lys Met Gln Gly Asp Thr 
     210                215                220
Ser Arg Gly Ile Glu Phe Gln Ala Val Pro Ser Glu Lys Ser Glu Val 
 225                230                235                240
Gly Gln Ala Leu Cys Leu Thr Ala Arg Glu Glu Asp Cys Phe Gln Ile 
                 245                250                255
Leu Asp Asp Cys Pro Pro Pro Pro Ala Pro Phe Pro His Arg Met Val 
             260                265                270
Glu Leu Arg Thr Gly Asn Val Ser Ser Glu Phe Ser Met Asn Ser Lys 
         275                280                285
Glu Ala Leu Gly Gly Gly Lys Phe Gly Ala Val Cys Thr Cys Met Glu 
     290                295                300
Lys Ala Thr Gly Leu Lys Leu Ala Ala Lys Val Ile Lys Lys Gln Thr 
 305                310                315                320
Pro Lys Asp Lys Glu Met Val Leu Leu Glu Ile Glu Val Met Asn Gln 
                 325                330                335
Leu Asn His Arg Asn Leu Ile Gln Leu Tyr Ala Ala Ile Glu Thr Pro 
             340                345                350
His Glu Ile Val Leu Phe Met Glu Tyr Ile Glu Gly Gly Glu Leu Phe 
         355                360                365
Glu Arg Ile Val Asp Glu Asp Tyr His Leu Thr Glu Val Asp Thr Met 
     370                375                380
Val Phe Val Arg Gln Ile Cys Asp Gly Ile Leu Phe Met His Lys Met 
 385                390                395                400
Arg Val Leu His Leu Asp Leu Lys Pro Glu Asn Ile Leu Cys Val Asn 
                 405                410                415
Thr Thr Gly His Leu Val Lys Ile Ile Asp Phe Gly Leu Ala Arg Arg 
             420                425                430
Tyr Asn Pro Asn Glu Lys Leu Lys Val Asn Phe Gly Thr Pro Glu Phe 
         435                440                445
Leu Ser Pro Glu Val Val Asn Tyr Asp Gln Ile Ser Asp Lys Thr Asp 
     450                455                460
Met Trp Ser Met Gly Val Ile Thr Tyr Met Leu Leu Ser Gly Leu Ser 
 465                470                475                480
Pro Phe Leu Gly Asp Asp Asp Thr Glu Thr Leu Asn Asn Val Leu Ser 
                 485                490                495
Gly Asn Trp Tyr Phe Asp Glu Glu Thr Phe Glu Ala Val Ser Asp Glu 
             500                505                510
Ala Lys Asp Phe Val Ser Asn Leu Ile Val Lys Asp Gln Arg Ala Arg 
         515                520                525
Met Asn Ala Ala Gln Cys Leu Ala His Pro Trp Leu Asn Asn Leu Ala 
     530                535                540
Glu Lys Ala Lys Arg Cys Asn Arg Arg Leu Lys Ser Gln Ile Leu Leu 
 545                550                555                560
Lys Lys Tyr Leu Met Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val 
                 565                570                575
Ser Ala Ala Asn Arg Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu Met 
             580                585                590
Ala Leu Gly Val 
         595



<210> 2519
<211> 1232
<212> DNA
<213> Rattus norvegicus
<308> J03969
<400> 2519

gttttccgt  cggcttctc  cacactcaa  tgcgcgcct  cacctcatg  aagactcga  60
ggacatgga  atgagccct  ttaggcctc  gaactacct  ttcggttgt  aactaaagg  120
tgacaaaga  tatcacttt  aagtggata  tgatgaaaa  gagcaccag  tatcattaa  180
aacggtcag  ttaggagca  gggcaaaag  tgagttgca  atcgtagag  cagaagcaa  240
gaactatga  ggcagccca  ttaaagtaa  actggcaac  ttgaaaatg  ctgtacaac  300
aacagtttc  cttgggggc  tcgaaatta  accacctgt  gtcttgagg  tgaagtgtg  360
ttctgggcc  gtgcacata  gtggacagc  cctagtagc  gtagaggaa  atgcagagt  420
agaagatga  gatgaggaa  atgtaaaac  cttaggcat  tctggaaag  gatctgctc  480
cggaggtgg  aacaaagtc  cacagaaaa  agtaaaact  gatgaagat  atgatgagg  540
tgatgaaga  gatgaggat  atgaagatg  tgatgatga  gattttgat  aagaggaaa  600
tgaagaaaa  gttccagtg  agaaatctg  acgagatac  ccagccaaa  atgcacaaa  660
atcaaacca  aatgggaaa  atttaaaac  atcaacacc  aggtcaaag  gtcaagagt  720
cttcaaaaa  caggaaaaa  ctcccaaaa  acccaaagg  cctagctct  tagaagaca  780
taaggcaaa  atgcaagca  gtatagaaa  aggtggttc  cttcccaaa  tggaagcca  840
gttcattaa  tatgtgaag  attgtttcc  gatgactga  caggaggct  ttcaagatc  900
ctggcagtg  aggaagtct  tttaagaaa  tggtttaaa  agtttgaaa  aattctgtc  960
tcatttctg  aatagttgc  atctggctg  cctttttat  atgcaaagt  agaactttc  1020
ctactgtgt  tgataaatg  tgtccaggt  caattgcca  gaatgtgtt  tctaaaatg  1080
ctgtttagt  ttcaaggat  gaactccgc  ctttacttg  ttttaagta  gtatggaat  1140
ttatgatag  acatagtag  agtggtggt  agatgtgga  atggtaggg  gacaaatat  1200
catgtgaaa  aaactcagt  ttttaataa  gt  1232



<210> 2520
<211> 292
<212> PRT
<213> Rattus norvegicus
<308> P13084
<400> 2520

Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn 
  1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys 
             20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser 
         35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala 
     50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys 
 65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro 
                 85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser 
             100                105                110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu 
         115                120                125
Asp Glu Glu Asp Val Lys Leu Leu Gly Met Ser Gly Lys Arg Ser Ala 
     130                135                140
Pro Gly Gly Gly Asn Lys Val Pro Gln Lys Lys Val Lys Leu Asp Glu 
 145                150                155                160
Asp Asp Asp Glu Asp Asp Glu Asp Asp Glu Asp Asp Glu Asp Asp Asp 
                 165                170                175
Asp Asp Asp Phe Asp Glu Glu Glu Thr Glu Glu Lys Val Pro Val Lys 
             180                185                190
Lys Ser Val Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn Gln 
         195                200                205
Asn Gly Lys Asp Leu Lys Pro Ser Thr Pro Arg Ser Lys Gly Gln Glu 
     210                215                220
Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly Pro Ser 
 225                230                235                240
Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu Lys Gly 
                 245                250                255
Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val Lys Asn 
             260                265                270
Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp Gln Trp 
         275                280                285
Arg Lys Ser Leu 
     290



<210> 2521
<211> 467
<212> DNA
<213> Homo sapiens
<308> AL135691
<400> 2521

gaaaaaggt  gttctcttc  caaagtgga  gccaaattc  tcaattatg  gaagaattg  60
ttccggatg  ctgaccaag  ggctattca  gatctctgg  agtggagga  gtctcttta  120
gaaaatagt  taaacaatt  tttaacaaa  tttcctgtg  ttagcttgt  gaaatgttt  180
gcatctgtc  attaaggaa  aaaaaaatc  ctctatgtt  ccccacttt  gagccctgt  240
tgccaccct  tgttcctgt  attgcaatg  gagaccgaa  gtaatatgg  aaacctacc  300
gtggggtgt  gttgtgccc  gagcacgtg  gtaaaggac  ggggaggcg  gtcttgaaa  360
agcaactgc  gaaattcct  atgatgatt  tgtgcaagt  agttaacat  aaccttcat  420
tgtaaattt  ttaaaattt  ttttataat  tgctttccg  agtcctt  467



<210> 2522
<211> 294
<212> PRT
<213> Homo sapiens
<308> NP_002511
<400> 2522

Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn 
  1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys 
             20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser 
         35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala 
     50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys 
 65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro 
                 85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser 
             100                105                110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu 
         115                120                125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala 
     130                135                140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala 
 145                150                155                160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp 
                 165                170                175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val 
             180                185                190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn 
         195                200                205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly 
     210                215                220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly 
 225                230                235                240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu 
                 245                250                255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val 
             260                265                270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp 
         275                280                285
Gln Trp Arg Lys Ser Leu 
     290



<210> 2523
<211> 1211
<212> DNA
<213> Rattus norvegicus
<308> J04035
<400> 2523

tcccctgct  cagctgcta  ggctgccaa  tatggtgct  ctggccttg  aggtgtcct  60
ggagccagg  cattcccag  cggaggagt  gcagcaaga  ctgggtttg  actttctcc  120
atctaccca  gtggtggtg  tgggggcct  ggagttggt  gaaaacccc  gaagcccta  180
ggaggagcc  ttggagccc  gggatatca  ggtgggggc  gctttggga  atcttgtgg  240
cggaagaga  agtgatctt  tggggaccc  tgactcgcg  cctcatcaa  gttggtgct  300
ctgcttggt  gagaatgta  accttctat  accaccccc  ctactccat  cccccgacc  360
ccacctggg  ggggacaac  ggccagtgg  cttggaaaa  ccacaggac  aggaaatca  420
acagcagca  ccacgtacc  ctaactaga  accccccca  atatcagag  ccagggcgg  480
tgtcccatc  cttcccacc  aggagctcc  ccacacagt  tccatctcc  agagaaatt  540
gtgctacat  ttggtgctt  ttctttgtg  ggggaggga  gagggaagg  tatcccagg  600
gggactccc  cttccctga  gcccctcta  taagatggt  cacaccttc  ctgggcagt  660
ctgcctccc  ctgcccacc  ggagccatt  ctggctgca  cccattggt  cccaagtac  720
agaagcctc  acattagat  tggtaacac  atccctctc  ctctttggg  cccctgtcc  780
tgactccca  taacaatag  tacttccca  acctgggac  ccttgaagt  cgacgactt  840
tcacactgg  aatagctcc  ttgttcttg  ggaatccac  tgccaacca  ccatccacg  900
actcatcca  ccttccatc  gtcatccat  catccgtcc  tccgtccgt  ctgactgcc  960
agtgccact  tctggctag  cacacccac  atcaacctg  ttcacctgt  atggcagcc  1020
gtacccacc  ccgccacac  ccccgacgc  ggcctatgg  gcaaagggt  gtgcgggct  1080
gtccttccc  catgcagta  tgtaatccc  gtccctcct  gagccactc  attacagag  1140
atgtctcac  aaccccacc  ctttgtgtt  cgctgtgat  gatcaataa  atattttat  1200
ttttgtcct  g  1211



<210> 2524
<211> 864
<212> PRT
<213> Rattus norvegicus
<308> Q99372
<400> 2524

Ala Val Pro Gln Pro Gly Val Leu Leu Ile Leu Leu Leu Asn Leu Leu 
  1               5                  10                  15
His Pro Ala Gln Pro Gly Gly Val Pro Gly Ala Val Pro Gly Gly Val 
             20                  25                  30
Pro Gly Gly Leu Pro Gly Gly Val Pro Gly Gly Val Tyr Tyr Pro Gly 
         35                  40                  45
Ala Gly Ile Gly Gly Gly Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly 
     50                  55                  60
Lys Pro Pro Lys Pro Gly Ala Gly Leu Leu Gly Ala Phe Gly Ala Gly 
 65                  70                  75                  80
Pro Gly Gly Leu Gly Gly Ala Gly Pro Gly Ala Gly Leu Ser Tyr Ala 
                 85                  90                  95
Ser Arg Pro Gly Gly Val Leu Val Pro Gly Gly Gly Ala Gly Ala Ala 
             100                105                110
Ala Ala Tyr Lys Ala Ala Ala Lys Ala Gly Ala Gly Leu Gly Gly Ile 
         115                120                125
Gly Gly Val Pro Gly Gly Val Gly Val Gly Gly Val Pro Gly Ala Val 
     130                135                140
Gly Val Gly Gly Val Pro Gly Ala Val Gly Gly Ile Gly Gly Ile Gly 
 145                150                155                160
Gly Leu Gly Val Ser Thr Gly Ala Val Val Pro Gln Leu Gly Ala Gly 
                 165                170                175
Val Gly Ala Gly Gly Lys Pro Gly Lys Val Pro Gly Val Gly Leu Pro 
             180                185                190
Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Thr Gly Ala Arg Phe Pro 
         195                200                205
Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Thr Gly Val Lys Ala 
     210                215                220
Lys Val Pro Gly Gly Gly Gly Gly Ala Phe Ser Gly Ile Pro Gly Val 
 225                230                235                240
Gly Pro Phe Gly Gly Gln Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
                 245                250                255
Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Asn Gly 
             260                265                270
Lys Leu Pro Tyr Gly Val Ala Gly Ala Gly Gly Lys Ala Gly Tyr Pro 
         275                280                285
Thr Gly Thr Gly Val Gly Ser Gln Ala Ala Val Ala Ala Ala Lys Ala 
     290                295                300
Ala Lys Tyr Ala Gly Ala Gly Gly Gly Gly Val Leu Pro Gly Val Gly 
 305                310                315                320
Gly Gly Gly Ile Pro Gly Gly Ala Gly Ala Ile Pro Gly Ile Gly Gly 
                 325                330                335
Ile Thr Gly Ala Gly Thr Pro Ala Ala Ala Ala Ala Ala Lys Ala Ala 
             340                345                350
Ala Lys Ala Ala Lys Tyr Gly Ala Ala Gly Gly Leu Val Pro Gly Gly 
         355                360                365
Pro Gly Val Arg Val Pro Gly Ala Gly Ile Pro Gly Val Gly Ile Pro 
     370                375                380
Gly Val Gly Gly Ile Pro Gly Val Gly Gly Ile Pro Gly Val Gly Gly 
 385                390                395                400
Ile Pro Gly Val Gly Gly Pro Gly Ile Gly Gly Pro Gly Ile Val Gly 
                 405                410                415
Gly Pro Gly Ala Val Ser Pro Ala Ala Ala Ala Lys Ala Ala Ala Lys 
             420                425                430
Ala Ala Lys Tyr Gly Ala Arg Gly Gly Val Gly Ile Pro Thr Tyr Gly 
         435                440                445
Val Gly Ala Gly Gly Phe Pro Gly Tyr Gly Val Gly Ala Gly Ala Gly 
     450                455                460
Leu Gly Gly Ala Ser Gln Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala 
 465                470                475                480
Ala Lys Tyr Gly Ala Gly Gly Ala Gly Thr Leu Gly Gly Leu Val Pro 
                 485                490                495
Gly Ala Val Pro Gly Ala Leu Pro Gly Ala Val Pro Gly Ala Leu Pro 
             500                505                510
Gly Ala Val Pro Gly Ala Leu Pro Gly Ala Val Pro Gly Val Pro Gly 
         515                520                525
Thr Gly Gly Val Pro Gly Ala Gly Thr Pro Ala Ala Ala Ala Ala Ala 
     530                535                540
Ala Ala Ala Lys Ala Ala Ala Lys Ala Gly Gln Tyr Gly Leu Gly Pro 
 545                550                555                560
Gly Val Gly Gly Val Pro Gly Gly Val Gly Val Gly Gly Leu Pro Gly 
                 565                570                575
Gly Val Gly Pro Gly Gly Val Thr Gly Ile Gly Thr Gly Pro Gly Thr 
             580                585                590
Gly Leu Val Pro Gly Asp Leu Gly Gly Ala Gly Thr Pro Ala Ala Ala 
         595                600                605
Lys Ser Ala Ala Lys Ala Ala Ala Lys Ala Gln Tyr Arg Ala Ala Ala 
     610                615                620
Gly Leu Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro 
 625                630                635                640
Gly Phe Gly Ala Gly Ala Gly Gly Phe Gly Ala Gly Ala Gly Val Pro 
                 645                650                655
Gly Phe Gly Ala Gly Ala Val Pro Gly Ser Leu Ala Ala Ser Lys Ala 
             660                665                670
Ala Lys Tyr Gly Ala Ala Gly Gly Leu Gly Gly Pro Gly Gly Leu Gly 
         675                680                685
Gly Pro Gly Gly Leu Gly Gly Pro Gly Gly Phe Gly Gly Pro Gly Gly 
     690                695                700
Leu Gly Gly Val Pro Gly Gly Val Ala Gly Gly Ala Pro Ala Ala Ala 
 705                710                715                720
Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Tyr Gly Leu Gly Gly 
                 725                730                735
Ala Gly Gly Leu Gly Ala Gly Gly Leu Gly Ala Gly Gly Leu Gly Ala 
             740                745                750
Gly Gly Leu Gly Ala Gly Gly Leu Gly Ala Gly Gly Leu Gly Ala Gly 
         755                760                765
Gly Val Ile Pro Gly Ala Val Gly Leu Gly Gly Val Ser Pro Ala Ala 
     770                775                780
Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu 
 785                790                795                800
Gly Ala Arg Pro Phe Pro Gly Gly Gly Val Ala Ala Arg Pro Gly Phe 
                 805                810                815
Gly Leu Ser Pro Ile Tyr Pro Gly Gly Gly Ala Gly Gly Leu Gly Val 
             820                825                830
Gly Gly Lys Pro Pro Lys Pro Tyr Gly Gly Ala Leu Gly Ala Leu Gly 
         835                840                845
Tyr Gln Gly Gly Gly Cys Phe Gly Lys Ser Cys Gly Arg Lys Arg Lys 
     850                855                860



<210> 2525
<211> 1448
<212> DNA
<213> Homo sapiens
<308> M17282
<400> 2525

agccgaaac  gagaggggc  ggactcaca  tgatgtgca  ctcctcccg  ccaggtggg  60
cctgcctgg  gaaagcttg  ggccggaag  gaaaatgag  ttcctagga  ccctgactc  120
cgacctcat  aacgttggt  ctactgctt  gtggagaat  taaaccctt  gtatcccca  180
cccatgccc  tccgattcc  caccccagg  gggaacggg  aggccgggc  gcttgcaga  240
ccacagggc  aggaaacaa  aggggagcg  ccaagtgcc  cgaccagga  gccccctac  300
tcagaggca  gggccatgt  gtcctggcc  cccaacccc  tcccttccc  cctaggagc  360
ccccctcca  acagcctcc  tctccaggg  aacttggtg  tacacgctg  tgctcttat  420
ttcctgggg  gagggagga  ggaagggtg  cccctcggg  aacccccta  ctggggctc  480
tctaaagat  gtgcagaca  ttcctgggc  gtcccagct  cccctgccc  ccaggaccc  540
ccgttggct  ccatccagt  ggtacccaa  cacctgaag  ctcaaagct  gattcgctc  600
agcatccct  ctctcctgg  tccacttgg  cgtctcctc  ccaccgatc  ctgttcccc  660
catctgggg  gcttttggg  tggaaaacc  ccccacact  ggaatagcc  ccttgcccc  720
tgtaagaat  catccgccc  tccgtccat  catccatcg  tccgtccat  catgtccca  780
ttgaccgcc  gcaccatta  ctggctggg  gcacccacc  tcaacctgg  tgacctgtc  840
tggccgcct  tgccctncc  nanccccat  ctacantcc  ccagggcgt  cggggctgt  900
cagactggg  tgccaggca  ctcnnnccc  cccggggtn  ccccanatg  agtactgta  960
annccccat  cctccctcg  tccactgaa  ttcagagca  ttcccattc  tgccccgnc  1020
atctttttg  gtctcgctg  gatagatca  taaatattt  attttttgt  ctggatatt  1080
ggggattat  tttgattgt  gatattctc  tttggtttt  ttgttgtgg  tcattgaaa  1140
aaaaaagat  atttttttt  ctgatccgg  gagctgtat  cccagtaga  aaaaaattt  1200
aatcactct  atatacctc  ggatgannc  naccttttt  tttattaag  aaagagatt  1260
aactgcttc  gaaatgact  ataaatgaa  accctttaa  ggaaactgt  tcttngctt  1320
cttggtatg  tttaatctg  cttcaactg  tggcctggn  ggggnnang  gctctgctt  1380
agggaacct  caccaccca  attgtattt  agaggttgc  caaccaaaa  cccctgctg  1440
ctggcttc  1448



<210> 2526
<211> 1728
<212> DNA
<213> Rattus norvegicus
<308> J04063
<400> 2526

tgactgtgc  ccgccgcgt  cgcccgccc  ccagtatgg  caccaccgc  acctgcacc  60
gcttcaccg  cgactacca  cttttcgag  agctcggca  gggtgcctt  tcggtggtc  120
ggaggtgcg  gaagaaaac  tcgacgcag  agtatgcag  aaaaatcat  aataccaag  180
agttgtctg  ccgagatca  cagaaacta  aacgagagg  ccggatatg  cgacttctg  240
aacatccaa  catcgtgcg  ctccatgac  gtatttctg  agaagggtt  cactacctc  300
tgtttgacc  tgttacggg  ggggagttg  ttgaagaca  cgtggccag  gaatactac  360
gcgaagctg  tgccagcca  tgtatacat  agatcctgg  gagcgtcaa  cacatccac  420
agcatgaca  cgtccaccg  gacctgaag  ccgagaact  gctgctggc  agtaaatgc  480
agggtgctg  ggtcaagct  gctgatttt  gcctggcca  cgaagtgca  ggagagcag  540
aggcttggt  tggttttgc  ggcacccca  gttacttgt  ccctgaggt  ttgaggaaa  600
atccctatg  aaaacctgt  gatatctgg  cctgcgggg  catcctgta  atcctcctg  660
tgggctacc  tcccttctg  gatgaggat  agcacaagc  ctatcagca  atcaaagct  720
gagcctacg  tttcccatc  ccagaatgg  acacagtca  tcctgaagc  aagaacttg  780
tcaaccaga  gttgaccat  aaccctgca  agcgtatca  agctgacca  gctctcaag  840
acccatggg  ctgtcaacg  tcaacagtg  catccatga  gcatcgcca  gagacagtg  900
agtgcttac  caagttcaa  gcccggaga  aactgaagg  tgccatcct  acaaccatg  960
ttgtctcca  gaacttttc  gttggcagg  agagctccg  ccccgcctc  cctgccgcg  1020
gcgccgccg  cctggccgg  caagctgcc  agagcctat  gaacaagaa  tcagatggc  1080
gcgtcaaga  aaggaagtc  agttccagc  tgcacctaa  ggagccaca  accaccgtg  1140
tacataatg  tacagatgg  atcaagggc  ccacagaga  ctgcaacac  accacagaa  1200
acgaagatc  caaagtgcg  aaacaggag  tcattaaga  cacagaaca  ctgatagaa  1260
ccatcaaca  tggggactt  gaggcctac  cgaagattt  tgacccagg  ctcacttcc  1320
ttgagccag  agcccttgg  aacctcgtg  aggggatgg  tttccataa  ttttacttt  1380
agaatctcc  gtccaagaa  agcaagcct  tccacacca  catcctaaa  ccacatgtc  1440
atgtcatcg  cgaggacgc  gcttgcatc  cctacatcc  gctcaccca  tacatcgat  1500
ggcagggtc  gcctcgcac  agtcagtca  aggagaccc  ggtgtggca  cgccgggat  1560
gcaagtggc  caatgtcca  tatcactgc  caggagccc  tgctgcacc  ctgcagtga  1620
ctcaggcac  ggggcatta  gagattcca  ctggaggct  aaccttcga  gtcagtgac  1680
ctggagggc  tgagtgaca  ccgcggtcc  gtccatttg  ggtttaaa  1728



<210> 2527
<211> 527
<212> PRT
<213> Rattus norvegicus
<308> P11730
<400> 2527

Met Ala Thr Thr Ala Thr Cys Thr Arg Phe Thr Asp Asp Tyr Gln Leu 
  1               5                  10                  15
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
             20                  25                  30
Lys Lys Thr Ser Thr Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
         115                120                125
Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
             180                185                190
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala Asp Gln Ala Leu Lys His Pro Trp Val 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Val Ser Arg Asn Phe Ser Val Gly Arg Gln Ser 
 305                310                315                320
Ser Ala Pro Ala Ser Pro Ala Ala Ser Ala Ala Gly Leu Ala Gly Gln 
                 325                330                335
Ala Ala Lys Ser Leu Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Lys 
             340                345                350
Arg Lys Ser Ser Ser Ser Val His Leu Met Glu Pro Gln Thr Thr Val 
         355                360                365
Val His Asn Ala Thr Asp Gly Ile Lys Gly Ser Thr Glu Ser Cys Asn 
     370                375                380
Thr Thr Thr Glu Asp Glu Asp Leu Lys Val Arg Lys Gln Glu Ile Ile 
 385                390                395                400
Lys Ile Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu 
                 405                410                415
Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu 
             420                425                430
Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe 
         435                440                445
Glu Asn Leu Leu Ser Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu 
     450                455                460
Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr 
 465                470                475                480
Ile Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser 
                 485                490                495
Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu 
             500                505                510
Asn Val His Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln 
         515                520                525



<210> 2528
<211> 1653
<212> DNA
<213> Homo sapiens
<308> BC021269
<400> 2528

ggcacgagg  gacttctga  acatccaaa  atcgtgcgc  tccatgaca  tatttctga  60
gaagggttt  actacctcg  gtttgacct  gttaccggc  gggagctgt  tgaagacat  120
gtggccaga  agtactaca  tgaagcaga  gccagccac  gtatacatc  gattctgga  180
agtgttaac  acatccacc  gcatgacat  gtccacagg  acctgaagc  tgagaacct  240
ctgctggcg  gtaaatgca  gggtgccgc  gtcaagctg  ctgattttg  cctagccat  300
gaagtacag  gagagcagc  ggcttggtt  ggttttgct  gcaccccag  ttacttgtc  360
cctgaggtc  tgaggaaag  tccctatgg  aaacctgtg  atatctggg  ctgcggggt  420
atcctgtat  tcctcctgg  gggctatcc  cccttctgg  atgaggatc  gcacaagct  480
tatcagcag  tcaaggctg  agcctatga  ttcccatca  cagaatggg  cacggtaac  540
cctgaagcc  agaacttga  caaccagat  ctgaccata  acccagcaa  gcgcatcac  600
gctgaccag  ctctcaagc  cccgtgggt  tgtcaacga  ccacggtgg  atccatgat  660
catcgtcag  agactgtgg  gtgtttgcg  aagttcaat  cccggagaa  actgaaggg  720
gccatcctc  cgaccatgc  tgtctccag  aacttctca  ctgccaaaa  cctattgaa  780
aagaagtcg  atggcggtg  caagccaca  agcaacaac  aaaacagtc  cgtaagccc  840
gcccaagag  ccgcgccct  gcagacggc  atggagcca  aaaccactg  ggtacacaa  900
gctacagat  ggatcaagg  ctccacaga  agctgcaac  ccaccacag  agatgagga  960
ctcaaagtg  gaaaacagg  gatcattaa  attacagaa  agctgattg  agccatcaa  1020
aatggggac  ttgaggcct  cacgaagat  tgtgatcca  gcctcactt  ctttgagcc  1080
gaggccctt  gtaacctcg  ggaggggat  gatttccat  agttttact  tgagaatct  1140
ctgtccaag  acagcaagc  tatccatac  accatccta  acccacacg  ccacgtgat  1200
ggggaggac  cagcgtgca  cgcctacat  cgcctcacc  agtacatcg  cgggcaggg  1260
cggcctcgc  ccagccagt  agaagagac  cgggtctgg  accgtcggg  tggcaagtg  1320
ctcaatgtc  actatcact  ctcaggggc  cctgccgca  cgctgcagt  agctcagcc  1380
caggggctt  aggagattc  agccggagg  ccaaccttc  cagccagtg  ctctggagg  1440
cctgagtga  agcggcagt  ctgtttgtt  gaggtttaa  acaattcaa  tacaaaagc  1500
gcagcagcc  atgcacgcc  ctgcatgca  ccctcccgc  cgcccttcg  gtctgtctc  1560
gctgtaccg  ggtgttttt  acatttaag  aaaaaaaaa  agaaaaaaa  attgtttaa  1620
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaa  1653



<210> 2529
<211> 2259
<212> DNA
<213> Rattus norvegicus
<308> J04187
<400> 2529

ctggctact  tgctggaca  aggactgct  ctggtggtc  tactggcct  cctaagtgt  60
atgttcttg  tgtccctct  gcagcagaa  atcagggag  gattgcctc  aggacccac  120
cctttgcct  tcattggaa  ttatctgca  ctgaatatg  aagacgtat  cagttccat  180
acacagctc  gtgagcgct  tggtcctgt  ttcaccatt  accttgggc  tcgacggat  240
gttgtgctt  atggatacg  tgcagtcaa  gaggctttg  tggaccaag  tgaggagtt  300
agtggacgt  gcgaactgc  tacctttaa  atactcttc  aaggctatg  tttttcatt  360
agcaatgtg  aacaggcca  gcgtatcag  cgcttcacc  tagccacat  gagagattt  420
ggtgtgggc  agcgtgatg  acaggagtg  atcctggag  aggcaggct  tttgatcaa  480
acgttgcag  gcacttgtg  agcccccat  gacccttcc  tctacctga  caaaacagt  540
tccaatgtc  ttaactcca  tgtcttcgg  aaccgcttc  actatgagg  caaagagtt  600
ttgtcactg  tggagatga  cgatgaaat  aatatattt  cagcctcag  cacagggca  660
ctctatgac  tgttccatt  agtgatgaa  tacctgcct  gaccacagc  acagatcat  720
aaggttact  agaaactgg  agacttcat  atagagaaa  tgaggcaga  ccatagtac  780
ctggacccc  attccccaa  gaacttcat  gactccttt  tcatccgca  gcaagagga  840
aaatatgtt  attcagaat  ccacatgaa  aacctagtg  tgtcatcat  aggcctcct  900
tttgctggg  ctgggtcag  cagctccac  ctataccat  gtttcctgc  actcatgaa  960
catccagat  tggaagcca  ggtccatga  gaaattgag  gagtgatcg  caggaaccg  1020
cagcctcag  atgaggacc  catgaagat  ccctacacc  aggctgtga  caatgagat  1080
caaagattt  ctaacttgg  tcccttggg  attcctcga  ggattatca  gaacacaac  1140
ttccgtggc  tcttcctcc  caagggcac  gatgtattc  ctataatag  ttctctgat  1200
acagaacca  agttcttcc  taaccacaa  gacttcaac  cccagcact  cctggatga  1260
aagggacag  tgaagaaga  tgctgcatt  ctccctttt  ccattggaa  gcgattctg  1320
ttgggagat  gcctggcta  aatggagct  ttcctgctg  tcaccacca  cttgcagaa  1380
ttccgtttt  agttcccaa  gaatctaga  gacatcaac  agtacccca  tcccatagg  1440
tttaccagg  tcataccaa  ttacaccat  agcttcatg  ccatctgat  ctgagttga  1500
tcaaggtgg  gcaagaggg  gggagagcc  gaagtgggg  cagggtgca  gtggagaga  1560
cagagaaga  gaagatgag  gttaagaag  gaccacacc  atggaagaa  cacaaaaga  1620
ttctcagtt  ggtaaaatt  taacagtcc  aataaaaag  aagaaacac  cagtaggca  1680
cagtaacaa  aactgagac  catggggca  aggtggctc  cctctgcag  agctgtcct  1740
cccttctct  actcagtcc  ctacacaag  gcagcatgt  cccaagccc  acgtacagg  1800
tcaaaagat  gaacttaaa  aatttgaac  taaactgag  tggaaaaga  acagttagc  1860
aggattgac  cattggact  tatcaccag  attcaggag  gagggaaca  ggctcccta  1920
gaggcctgc  agaattaca  agtgaaact  atctcaaaa  aggaacaac  gaaaataaa  1980
tttcaaatt  atttctctt  gaccataag  gtccagatc  gtatccaaa  ctatttggt  2040
atatttttt  ttattgttg  tttgtttac  cattgtgtt  ttctttcgg  ttgtaagtc  2100
gtttgggat  tttaattta  atttactga  tagtgtggg  ggtagggca  accatggct  2160
aaatgtgga  accaaagaa  agcttttgg  agtgtcatc  cccttacaa  acgtgtgtc  2220
aagaactca  attcagaca  taaagcttg  tagcaagca  2259



<210> 2530
<211> 492
<212> PRT
<213> Rattus norvegicus
<308> P15149
<400> 2530

Met Leu Asp Thr Gly Leu Leu Leu Val Val Ile Leu Ala Ser Leu Ser 
  1               5                  10                  15
Val Met Phe Leu Val Ser Leu Trp Gln Gln Lys Ile Arg Glu Arg Leu 
             20                  25                  30
Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln Leu 
         35                  40                  45
Asn Met Lys Asp Val Tyr Ser Ser Ile Thr Gln Leu Ser Glu Arg Tyr 
     50                  55                  60
Gly Pro Val Phe Thr Ile His Leu Gly Pro Arg Arg Ile Val Val Leu 
 65                  70                  75                  80
Tyr Gly Tyr Asp Ala Val Lys Glu Ala Leu Val Asp Gln Ala Glu Glu 
                 85                  90                  95
Phe Ser Gly Arg Gly Glu Leu Pro Thr Phe Asn Ile Leu Phe Lys Gly 
             100                105                110
Tyr Gly Phe Ser Leu Ser Asn Val Glu Gln Ala Lys Arg Ile Arg Arg 
         115                120                125
Phe Thr Ile Ala Thr Leu Arg Asp Phe Gly Val Gly Lys Arg Asp Val 
     130                135                140
Gln Glu Cys Ile Leu Glu Glu Ala Gly Tyr Leu Ile Lys Thr Leu Gln 
 145                150                155                160
Gly Thr Cys Gly Ala Pro Ile Asp Pro Ser Ile Tyr Leu Ser Lys Thr 
                 165                170                175
Val Ser Asn Val Ile Asn Ser Ile Val Phe Gly Asn Arg Phe Asp Tyr 
             180                185                190
Glu Asp Lys Glu Phe Leu Ser Leu Leu Glu Met Ile Asp Glu Met Asn 
         195                200                205
Ile Phe Ala Ala Ser Ala Thr Gly Gln Leu Tyr Asp Met Phe His Ser 
     210                215                220
Val Met Lys Tyr Leu Pro Gly Pro Gln Gln Gln Ile Ile Lys Val Thr 
 225                230                235                240
Gln Lys Leu Glu Asp Phe Met Ile Glu Lys Val Arg Gln Asn His Ser 
                 245                250                255
Thr Leu Asp Pro Asn Ser Pro Arg Asn Phe Ile Asp Ser Phe Leu Ile 
             260                265                270
Arg Met Gln Glu Glu Lys Tyr Val Asn Ser Glu Phe His Met Asn Asn 
         275                280                285
Leu Val Met Ser Ser Leu Gly Leu Leu Phe Ala Gly Thr Gly Ser Val 
     290                295                300
Ser Ser Thr Leu Tyr His Gly Phe Leu Leu Leu Met Lys His Pro Asp 
 305                310                315                320
Val Glu Ala Lys Val His Glu Glu Ile Glu Arg Val Ile Gly Arg Asn 
                 325                330                335
Arg Gln Pro Gln Tyr Glu Asp His Met Lys Met Pro Tyr Thr Gln Ala 
             340                345                350
Val Ile Asn Glu Ile Gln Arg Phe Ser Asn Leu Ala Pro Leu Gly Ile 
         355                360                365
Pro Arg Arg Ile Ile Lys Asn Thr Thr Phe Arg Gly Phe Phe Leu Pro 
     370                375                380
Lys Gly Thr Asp Val Phe Pro Ile Ile Gly Ser Leu Met Thr Glu Pro 
 385                390                395                400
Lys Phe Phe Pro Asn His Lys Asp Phe Asn Pro Gln His Phe Leu Asp 
                 405                410                415
Asp Lys Gly Gln Leu Lys Lys Asn Ala Ala Phe Leu Pro Phe Ser Ile 
             420                425                430
Gly Lys Arg Phe Cys Leu Gly Asp Ser Leu Ala Lys Met Glu Leu Phe 
         435                440                445
Leu Leu Leu Thr Thr Ile Leu Gln Asn Phe Arg Phe Lys Phe Pro Met 
     450                455                460
Asn Leu Glu Asp Ile Asn Glu Tyr Pro Ser Pro Ile Gly Phe Thr Arg 
 465                470                475                480
Ile Ile Pro Asn Tyr Thr Met Ser Phe Met Pro Ile 
                 485                490



<210> 2531
<211> 8778
<212> DNA
<213> Homo sapiens
<308> U22028
<400> 2531

tgggtccaa  caaaatcaa  gtcaattcc  tgggcccag  gctgggctg  tgggctttt  60
tgggagcac  tgctgggct  gctacacac  ccacctccc  gaaactcca  acccacagc  120
ctgggtctt  ctagcccca  gactttcaa  tccatatgc  tggaatccc  cgtcctgag  180
cccttaacc  tgcatcctc  acaacagaa  acccccaga  gcacagcca  acttccatc  240
caccctagt  aaacccaga  ctttggatt  ctctcccgt  gaatgccca  atccacaac  300
ttggggtgc  gtctcactc  cagatccca  atccaaaga  caggtgctc  cctgtgcaa  360
tattccaaa  tcctcagtt  cacagttta  ctgttgccc  ctcctaaat  cacaggccc  420
gcagcaacc  tcctgaagt  gcagagtta  actggagtt  ccctccctg  tcatcttgc  480
ctggggtcc  tctcctcct  ccttgctgg  tgtgtccta  gctgtgtgg  attcagggt  540
ggggtgtag  tgggaggtg  aatgaggtg  ttatataat  aaccacagt  catccctct  600
tttcaggca  tataaaggc  aaccacccc  gccatcacc  tctatcatc  catggccac  660
atgctggcc  cagggctgc  tctggtgac  ttgctggcc  gcctgactg  gatggtctt  720
atgtcagtc  ggcggcaga  gaagagcag  gggaagctg  ctccgggac  caccccatt  780
cccttcatt  gaaactacc  ccagctgaa  acagagcag  tgtacaact  cctcatgaa  840
gtgtcctaa  gcaggagat  ggtggcacg  ggtgggggc  gcccagttg  ctggggctt  900
gtggcaggg  attgaccag  gtggaccag  gtcttagga  agggagtct  ggagtttca  960
catcagggt  ctagcagga  agacaggat  ttgggatgt  cagctccct  actgtgaga  1020
cctgggggc  aagcatccc  gtacatgat  tctcagcgc  gggcccatt  agagtgggg  1080
ctgctccct  taaccactc  cacctgcct  caacagatc  gtgagcgct  tggccctgt  1140
ttcaccatt  acttggggc  ccggcgggt  gtggtgctg  gcggacatg  tgccgtcaa  1200
gaggctctg  tggaccagg  tgaggagtt  agcgggcga  gcgagcagg  caccttcga  1260
tggctcttc  aaggctatg  tgagggggt  ccaagaggg  gaaggtggt  aggtggatg  1320
aatggtctc  gtgtcccca  ccttctccc  gactctcct  cccactgga  gatatggga  1380
agccccctg  ctggtcttc  ctccccatc  ccctacatc  gggactctc  ctgtgagtc  1440
cacacctgt  tccagcgcc  ctggcgtga  tcctccctg  ctctctctg  cccgtctcc  1500
ccttctctc  cactggagt  tcctcttac  cctctctct  catctctga  gacatccgg  1560
gtttctgtt  accagccct  gtcctctgt  ttcatttgt  tttttgtcg  tctcggctt  1620
tgtgcttct  cgtgtttct  ctctctctg  ttccctctc  cacttcttc  tctgtctta  1680
gatttcagg  tattcctac  tccacatct  cagctccca  ctcctggta  ttgtctgtc  1740
tccttcccg  tcctctctg  ttctgtctc  atatttttc  ctctcttct  cagttcaga  1800
taagaatct  tcaccattt  tatttcctc  tcccagatc  ccccatatc  cacttcccc  1860
ccctccatc  ctctctttc  ctccccact  ccttccctt  ctccatgga  tatccccgt  1920
tccctctgt  tctctgcat  tgtctgtct  gcctttctg  ttctcttct  attctctta  1980
tctttctac  cggactctc  ctctctctc  ctctctctc  ctctctctc  ctctctctc  2040
ctctctctc  ctctctcgt  ctctcgtgt  tctctgact  agagtgtag  tctcctggg  2100
actcgcgct  aatccatct  tctcccaca  cactccctc  ctacaccac  cttggggag  2160
cccttggaa  tggtccgct  ctgctacca  caccccctg  cctctctcc  cccccgcgt  2220
cacctcccc  ggcgtggcg  tcagcaacg  ggagcgcgc  aagcagctc  ggcgcttct  2280
catcgccac  ctaaggggt  ttggcgtgg  caagcgcgg  atcgaggaa  gcatccagg  2340
ggaggcggg  ttcctcatc  acgccctcc  gggcacgca  ggtgagtag  ggaccccga  2400
tgcgagggc  ggaacccgc  ctttctgcc  ggggatggg  actaggtgg  gaaaggggc  2460
cgcacttcc  gccctggag  ctggcgctg  gattcggct  aacagggcc  tgcctcctg  2520
aattctgac  ctcctcaga  ctctgagtt  actctctcc  caacccccc  tctcccgcc  2580
cacctgtag  cgccaatat  gatcccacc  tcttcctga  ccgcacagt  tccaatgtc  2640
tcagctcca  tgtctttgg  gaccgcttt  actatgagg  caaagagtt  ctgtcactg  2700
tgcgcatga  gctgggaag  ttccagttc  cgggaacct  cacggggca  gtaactgga  2760
gcagcccgc  agtgacgcc  ctaccacaa  ctgccaact  ctcccctac  tggagacag  2820
tgccccaaa  tcccacccc  ctccagaca  tgtcccctc  aaatcagtc  ccgatattg  2880
acaactgga  ggttggacc  gaacccagg  gggatgccc  atacccagt  tccaaggac  2940
cctggatag  tcaacagat  atccccaaa  cagagcctg  tggcaggat  cataccctc  3000
gctcagctc  ctcacctgg  cacatgttc  catccccat  ttaccgtaa  ttgtaacag  3060
tgctcccta  ccagttctt  tgaatattt  acacctgga  aagtgactg  gtcaacccg  3120
ctcctgcat  cctgaacac  tggtgctgc  aaatccagg  catcataat  atttcacat  3180
tacacaaat  tcacagatt  gcccactgg  aatatctgg  caagggccc  ctacttcac  3240
cacttaaat  cctgaaaac  tggacaggt  ccctaacca  taccctaaa  acataaata  3300
ctagataga  tattccctg  cacccaaat  agtgttccc  aaccctttc  aatcacaca  3360
cttacagag  tgctcccag  gcatcccac  tggataggt  aacacctca  caggtatcc  3420
ctccacttc  gcatcttca  cagccccac  ttatacctg  gcacctgaa  aaaagcccc  3480
aatccagac  cagtaagta  ctggacagc  gtctccaac  aagtccact  gaatgccta  3540
atacctaga  aggtgccac  cacctcata  cagccccac  tgaagagct  aacacctgg  3600
caggtgtct  ccaactcaa  ttcacttga  tatctgaac  cctagatgt  tgctccaat  3660
cagcctcat  tgcatacct  aaacctgga  atatgcctc  gttcttctc  cctaaatta  3720
tagaccgtg  ccctggcac  taatccacg  gaaaactta  atataagtt  ccatccaac  3780
ccactgaaa  acctaaaca  ctggacaga  gcctttaac  ccgttcctt  cttgctatg  3840
aacaaatcc  cattcccat  agctcctgc  ccgtgacag  tgtccttcc  ttcccatcc  3900
ctctctgca  ccccagctc  atgagatgt  ctcttcggt  atgaaacac  tgccaggac  3960
acagcaaca  gcctttaag  agctgcaag  gctggagga  ttcatcgcc  agaaggtgg  4020
gcacaacca  cgcacgctg  atcccaatt  cccacggga  ttcatcgac  cctttctca  4080
ccgcatgca  gaggtacat  ccagcagcc  gtgcaggca  gtgcaaagc  agggagagg  4140
aaatcagga  gggagtggg  tgggcagac  acacaggcc  attcaaatt  gccctcgtc  4200
taataatcc  tacaattgg  caggcgcgg  ggctcatga  ctgtaatcc  agcactttg  4260
gaggccgag  caggtggat  acctgaggt  aggagttcg  gaccagcct  gccaacatg  4320
tgaaacccc  tctctacta  aaatacaaa  atgagctag  tatggtggc  tgcgcctgt  4380
atcccagct  ctcaggagg  tgagacaga  gaatttgtt  gaatccggg  ggcagaggt  4440
gcagtgagc  gggatcatg  cactgcact  cggcctgag  gacagagca  gaccctgta  4500
aaaaaaaaa  aaaaaaaaa  aaaaattcc  gaaaacccc  attacatca  ccactgctg  4560
cccatctac  gagccctca  ccacaagga  gggttatgg  ggtggatta  attggaaag  4620
acttctcaa  aactaccgg  tgccaggaa  tgggttaag  gttttatga  agtccgcca  4680
ggaacactt  taacagttc  tgagggagg  tcactcatg  ccccagttg  acaaatgag  4740
aaactgagg  ccagagagt  taagtgtct  aactgaggt  acaacagtg  ggaagacca  4800
ggtccccct  gctcaaacc  tggtctctc  gagcctata  ctggtgctt  tagccacca  4860
gctctctaa  cgttcatgt  ctggttagc  gacacacct  tgtggacag  tgacctggc  4920
ttacattgc  gggtccccg  ctacctctg  atgtcagcc  cccatgtgg  aaggcttta  4980
gaagccaaa  ctcagggag  aaggatcaa  ggagggatt  ctccacagt  agtttcaag  5040
tttttaggg  agaaatagg  tgctgttgc  taaaattct  tgcttgtat  tcagaaaaa  5100
tcttttttt  tgactcttc  tcttgccat  tctgtacta  tttctcttc  tctcccctc  5160
tccttctct  tccaaatat  cctatcatt  aaaaagtaa  agactggga  acatggcaa  5220
accccgtct  tacaaaaaa  tggctaggc  tggtggtgc  tgcctgcgg  cccagctac  5280
aaggaggtt  aggtgggag  atatcttga  cccagggtg  gcagaggtt  caatgagcc  5340
atatcacag  cctgccctc  agcctgggt  acagaataa  accgtgtct  ccaaaaaaa  5400
aaagaatta  ttttttaac  gttaacaag  gagcctgca  agtcatgtg  atgtgcagt  5460
ccagctact  tggaggctg  gaccggagg  ttccttgaa  ccaggagtt  gagtccagc  5520
tgtgcaact  agcaagacc  agtctgcat  aaaaaaaaa  aaaccaact  acagctaag  5580
tgacaatta  aggatagat  atcagtgag  taaagaagg  gagaaggaa  agcattttg  5640
gcaaagcca  cagccaggg  aagggctgg  acctggagc  agtttggca  atctagggt  5700
cctctttcc  cctttggtc  ggaccaaag  gaggtagct  caaaggaaa  gccctagaa  5760
ggccccaag  gcatggaga  tgagcttgg  ctaaaccgc  ctctccctg  aggaggaga  5820
gaaccccaa  acagagttc  acttgaaga  cctggtgat  accaccctg  acctcttct  5880
tgcgggcac  gagaccgtg  gcaccaccc  gcgctacgg  ttcctgctg  tcatgaagc  5940
cccagaggt  gagggtaag  ctggaaagg  aggaaagtg  agggcccca  accctcaaa  6000
ctcccctga  cctggtgca  tgtacccac  tatcccaga  cccaggacc  tgagacgtg  6060
cttgctgtc  agagacagg  caatattca  ctgataggc  tcagctgag  ctcattagc  6120
attaaaata  tgaaaatgt  tgcactgat  ggtcagtca  tcctgtccc  agcccactg  6180
gtgtccgct  cctgctcct  tggatcatc  cctaagttc  tcccttgtc  taccctgtg  6240
ttctgacac  acctggttt  acagggatc  tgctgcaaa  aatgcgaat  ggtgatgtc  6300
tgttcttgt  tatgaatgg  cttaccctt  gtgtcagag  tggaagcta  gtcaaccgc  6360
gtgttttag  taggggggg  gatacatgc  ctgctctaa  acccctaga  agggtaaag  6420
tattcccct  ctccgccag  caaggtcca  gaggagatt  acagagtga  cggcaagaa  6480
cggcagccc  agtttgagg  ccgggccaa  atgccctac  cagaggcag  gatccacga  6540
atccaaaga  ttggagaca  gctccccat  ggtttggcc  acagggtca  caaggacac  6600
aagtttcgg  atttcttcc  ccctaaggt  ctgtctccc  tccaccacc  ccactcaga  6660
tacggggac  tccagcctc  ctctgtgtc  ccagaatcc  gcccccatt  gtgttctag  6720
ctctgtccc  ctccctcaa  cagtcaaaa  agacttccc  aaccaccac  tctgttcca  6780
ctttccact  agacagtcc  gagtcctgc  tctcgccag  ctctttgtg  caggagaat  6840
caccccatg  tcccaatct  cctgtctta  gaaacagaa  ccccctttc  attaggcct  6900
gtggcttag  gacacaaat  tcaggtccc  caaacaccc  ggctagtgg  acatggacc  6960
catgtctcc  aaacttcct  tctcagaga  atgaaactt  tatccccca  agctcctcc  7020
tcagaggtc  ccaactcct  catgtcgtg  cactccccg  acctggggg  ccctagagc  7080
ccctggagc  cctgtgtac  ttcaccaat  cccccaacc  ggctcataa  acacacctt  7140
ctcctccct  ccagggcac  gaagtgttc  ctatgctgg  ctccgagct  agagacccc  7200
ggttcttct  caaccccca  gactgcagt  cccagcact  cctggatga  aaggggcag  7260
ttaagaaga  tgatgcttt  gtgcccttt  ccatcggta  gagacactg  ttgctgcca  7320
gccacggct  acaccagca  gggcctctc  cacccacct  ccctctctg  ggtgtagcc  7380
ggtatttct  cagcttgga  gttcctgtt  gaatctacc  ttgagccgc  accagctga  7440
actccctta  ctgccaagc  cccaatacc  gcgcccagg  aaaagggaa  gaaacatct  7500
cccccatag  tttatttgt  tagggtcac  cagcagatt  ttcagctcc  tgaaaagga  7560
ataatggta  agcacagca  tcatatttg  aagtgtatc  ggggggtag  ggcatctaa  7620
cctcccatt  ctacacctg  catggatca  cccatctat  atggaggca  gacattatg  7680
ctttttcga  acccataga  ctgtataac  cagagtaaa  cctaatgta  actatggac  7740
ttggttagt  ataatatat  aatattggt  caccattgt  atatctctt  tagaaggaa  7800
ctgaagctc  gggaggatc  gagtctcct  tgaaagtct  tcaggccat  atattccca  7860
ccctcctcc  tagagagtg  agccggggg  cagtagggg  tgaggctgc  ctgagagtg  7920
gcttcacct  cacccctcc  gcctctcct  ctcaggaaa  cggtactgt  ttggagaag  7980
cctggccag  atggagctc  ttctcttct  caccaccat  atgcagaac  ttcgcttca  8040
gtcccctca  tcgcctaag  atatcgacg  gtcccccaa  cacgtgggc  ttgccacga  8100
cccacgaaa  tacaccatg  gcttcctgc  ccgctgagc  agggctgtg  tggtgcagg  8160
ctggtgggc  gggccaggg  aacggccgg  gcaggggcg  ggcttgtgg  aggggcggg  8220
ctaagaatg  gggcagtgg  ggaaggaag  ggagaggtg  ttagaggga  cagaagaaa  8280
agaaggggc  cagttcacc  tgatgatgt  cttcagagc  gtgatgaga  gaagggaaa  8340
cttacagta  gctacaaag  gtagtaata  tagcagctc  tatctcctg  acaagtccc  8400
ccctgtcag  tttgttcaa  aagcgttgc  cgctcacct  acttatttg  cacacacct  8460
taccaatgg  ggaaaagtc  tcattcccc  ttttacacg  gagaaaggt  cggctcaga  8520
agttgtctc  atctgaaaa  tcacaaaac  caagtgtcc  gaggatctt  gaacacaga  8580
ctgggccca  agccctcta  atcgatcct  accatagca  cccttcttc  cgtaaaata  8640
cttagtata  catcacatg  cctgaacac  cctgggccg  ggggttccc  agagacctg  8700
cgggcggct  ccctgccta  tctgtacac  cgcctactc  ggacgatcc  ggcaccagg  8760
tgtcacctg  gctcgcta  8778



<210> 2532
<211> 494
<212> PRT
<213> Homo sapiens
<308> Q16696
<400> 2532

Met Leu Ala Ser Gly Leu Leu Leu Val Thr Leu Leu Ala Cys Leu Thr 
  1               5                  10                  15
Val Met Val Leu Met Ser Val Trp Arg Gln Arg Lys Ser Arg Gly Lys 
             20                  25                  30
Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln 
         35                  40                  45
Leu Asn Thr Glu Gln Met Tyr Asn Ser Leu Met Lys Ile Ser Glu Arg 
     50                  55                  60
Tyr Gly Pro Val Phe Thr Ile His Leu Gly Pro Arg Arg Val Val Val 
 65                  70                  75                  80
Leu Cys Gly His Asp Ala Val Lys Glu Ala Leu Val Asp Gln Ala Glu 
                 85                  90                  95
Glu Phe Ser Gly Arg Gly Glu Gln Ala Thr Phe Asp Trp Leu Phe Lys 
             100                105                110
Gly Tyr Gly Val Ala Phe Ser Asn Gly Glu Arg Ala Lys Gln Leu Arg 
         115                120                125
Arg Phe Ser Ile Ala Thr Leu Arg Gly Phe Gly Val Gly Lys Arg Gly 
     130                135                140
Ile Glu Glu Arg Ile Gln Glu Glu Ala Gly Phe Leu Ile Asp Ala Leu 
 145                150                155                160
Arg Gly Thr His Gly Ala Asn Ile Asp Pro Thr Phe Phe Leu Ser Arg 
                 165                170                175
Thr Val Ser Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp 
             180                185                190
Tyr Glu Asp Lys Glu Phe Leu Ser Leu Leu Arg Met Met Leu Gly Arg 
         195                200                205
Phe Gln Phe Thr Gly Thr Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser 
     210                215                220
Ser Val Met Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Lys Glu 
 225                230                235                240
Leu Gln Gly Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln 
                 245                250                255
Arg Thr Leu Asp Pro Asn Ser Pro Arg Asp Phe Ile Asp Ser Phe Leu 
             260                265                270
Ile Arg Met Gln Glu Glu Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu 
         275                280                285
Lys Asn Leu Val Met Thr Thr Leu Asn Leu Phe Phe Ala Gly Thr Glu 
     290                295                300
Thr Val Ser Thr Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His 
 305                310                315                320
Pro Glu Val Glu Ala Lys Val His Glu Glu Ile Asp Arg Val Ile Gly 
                 325                330                335
Lys Asn Arg Gln Pro Lys Phe Glu Asp Arg Ala Lys Met Pro Tyr Thr 
             340                345                350
Glu Ala Val Ile His Glu Ile Gln Arg Phe Gly Asp Met Leu Pro Met 
         355                360                365
Gly Leu Ala His Arg Val Asn Lys Asp Thr Lys Phe Arg Asp Phe Phe 
     370                375                380
Leu Pro Lys Gly Thr Glu Val Phe Pro Met Leu Gly Ser Glu Leu Arg 
 385                390                395                400
Asp Pro Arg Phe Phe Ser Asn Pro Gln Asp Cys Ser Pro Gln His Phe 
                 405                410                415
Leu Asp Glu Lys Gly Gln Phe Lys Lys Ser Asp Ala Phe Val Pro Phe 
             420                425                430
Ser Ile Gly Lys Arg Tyr Cys Phe Gly Glu Gly Leu Ala Arg Met Glu 
         435                440                445
Leu Phe Leu Phe Phe Thr Thr Ile Met Gln Asn Phe Arg Phe Lys Ser 
     450                455                460
Pro Gln Ser Pro Lys Asp Ile Asp Val Ser Pro Lys His Val Gly Phe 
 465                470                475                480
Ala Thr Ile Pro Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg 
                 485                490



<210> 2533
<211> 1482
<212> DNA
<213> Rattus norvegicus
<308> J04486
<400> 2533

gatcacagg  ttggacact  cattctttc  aactcccca  ctaaaagtg  ccttaacta  60
ttactagac  gattggctg  agacctagc  cccaaggga  gatttggcc  gggtgatgc  120
tggcccact  agaggacac  agtgctttt  ccccttagc  gcattgtcc  ggaaatcaa  180
acgacaaaa  gcgtctccc  cgctcgcca  ggccgtgcc  cctgcccgc  agctcgccg  240
gctacggtt  cccactagc  aacatgctg  cgagattgg  cggccccgc  ctgccgctg  300
tcctgccgt  gctgctctt  ctgctgctg  tgggcgcgg  cggttgcgg  cctggggtg  360
gcgccgagg  gctgttccg  tgcccaccc  gcacgcccg  gcgtctggc  gcctgcgga  420
ccccacccg  cgcgccctg  gccgagctg  tgcgagagc  cggctgcgg  tgctgctcc  480
tgtgcgcac  acaggaggg  gaagcttgc  gcgtctaca  cccgcgctg  gcccagacg  540
tacgctgtt  ccccaaccc  ggctccgag  tgcccctga  ggcactggt  accggcgcg  600
gtacctgtg  aaagagacg  gtgggcgcc  ccccacagc  ggttgcaga  agtgaggat  660
accactcgg  gggaggcct  gtggagaac  atgtggacg  aaccatgaa  atgttagga  720
gcagcagtg  tggccggaa  ccccctaag  caggcatga  ggaactggc  gtgttccgg  780
agaaggtca  cgagcagca  cggcagatg  gcaaaggtg  caaacacct  agcctggag  840
agcccaaga  gctgcgccc  cctcctgcc  ggacccctt  ccagcagga  ctggaccag  900
tcctggagc  catctccac  atgcgcctt  cggatgatc  gggtcctct  gaacatctc  960
actccctgc  tatccccaa  tgtgacaag  atggcctgt  caacctcaa  cagtgcaag  1020
tgtctctga  tggacagcg  ggggagtgc  ggtgtgtga  ccccaatac  gggaagcca  1080
tccagggag  tcccaccat  cggggagac  ccgagtgcc  tctcttcta  aacgagcag  1140
aggagaatg  tggggttca  gcccaaagg  tgcagtaaa  cacagccag  cggtgcctg  1200
cttccccac  ccaaacacc  gcagaaatg  agggtgtca  ggtgatggg  gtggaggat  1260
tcccagttt  gacacatgt  tttatattt  gaaagagac  aacactgag  tcagaagcc  1320
ccctgcgcc  cccagtggc  gttaacctg  acctctgtt  ctgcttcta  tagagaggg  1380
ggtggcact  gggatactg  gtacaggct  gggaatggg  aaagaaatt  ttatttttg  1440
acccctgtg  ctcttttac  taagattaa  ggaaggaaa  at  1482



<210> 2534
<211> 304
<212> PRT
<213> Rattus norvegicus
<308> P12843
<400> 2534

Met Leu Pro Arg Leu Gly Gly Pro Ala Leu Pro Leu Leu Leu Pro Ser 
  1               5                  10                  15
Leu Leu Leu Leu Leu Leu Leu Gly Ala Gly Gly Cys Gly Pro Gly Val 
             20                  25                  30
Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu 
         35                  40                  45
Ala Ala Cys Gly Pro Pro Pro Asp Ala Pro Cys Ala Glu Leu Val Arg 
     50                  55                  60
Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Gln Glu Gly Glu 
 65                  70                  75                  80
Ala Cys Gly Val Tyr Ile Pro Arg Cys Ala Gln Thr Leu Arg Cys Tyr 
                 85                  90                  95
Pro Asn Pro Gly Ser Glu Leu Pro Leu Lys Ala Leu Val Thr Gly Ala 
             100                105                110
Gly Thr Cys Glu Lys Arg Arg Val Gly Ala Thr Pro Gln Gln Val Ala 
         115                120                125
Asp Ser Glu Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val 
     130                135                140
Asp Gly Thr Met Asn Met Leu Gly Gly Ser Ser Ala Gly Arg Lys Pro 
 145                150                155                160
Pro Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Asn 
                 165                170                175
Glu Gln His Arg Gln Met Gly Lys Gly Ala Lys His Leu Ser Leu Glu 
             180                185                190
Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln Gln 
         195                200                205
Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro Asp 
     210                215                220
Asp Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn Cys 
 225                230                235                240
Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu Asn 
                 245                250                255
Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys Pro 
             260                265                270
Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu Phe 
         275                280                285
Tyr Asn Glu Gln Gln Glu Asn Asp Gly Val His Ala Gln Arg Val Gln 
     290                295                300



<210> 2535
<211> 1387
<212> DNA
<213> Homo sapiens
<308> M35410
<400> 2535

gtgccacct  cccgcccgc  cgctcgctc  ctcgcccgc  gcgccgcgc  gccgaccgc  60
agcatgctg  cgagagtgg  ctgccccgc  ctgccgctg  cgccgccgc  gctgctgcc  120
ctgctgccg  tgctgctgc  gctactggg  gcgagtggc  gcggcggcg  ggcgcgcgc  180
gaggtgctg  tccgctgcc  gccctgcac  cccgagcgc  tggccgcct  cgggccccc  240
ccggttgcg  cgcccgccg  ggtggccgc  gtggccgga  gcgcccgca  gccatgcgc  300
gagctcgtc  gggagccgg  ctgcggctg  tgctcggtg  gcgcccggc  ggagggcga  360
gcgtgcggc  tctacaccc  gcgctgcgg  caggggctg  gctgctatc  ccacccggg  420
tccgagctg  ccctgcagg  gctggtcat  ggcgagggc  cttgtgaga  gcgccggga  480
gccgagtat  gcgccagcc  ggagcaggt  gcagacaat  gcgatgacc  ctcagaagg  540
ggcctggtg  agaaccacg  ggacagcac  atgaacatg  tgggcgggg  aggcagtgc  600
ggccggaag  ccctcaagt  gggtatgaa  gagctggcc  tgttccggg  gaaggtcac  660
gagcagcac  ggcagatgg  caagggtgg  aagcatcac  ttggcctgg  ggagcccaa  720
aagctgcga  caccccctg  caggactcc  tgccaacag  aactggacc  ggtcctgga  780
cggatctcc  ccatgcgcc  tccggatga  cggggccct  tggagcacc  ctactccct  840
cacatcccc  actgtgaca  gcatggcct  tacaacctc  aacagtgca  gatgtctct  900
aacgggcag  gtggggagt  ctggtgtgt  aaccccaac  ccgggaagc  gatccaggg  960
gcccccacc  tccgggggg  ccccgagtg  catctcttc  acaatgagc  gcaggaggc  1020
cgcggggtg  acacccagc  gatgcagta  accgcagcc  gccggtgcc  ggcgcccct  1080
ccccccgcc  ctctccaaa  accggcaga  aacggagag  gcttgggtg  tgggtgctg  1140
aggattttc  agttctgac  cacgtattt  tatatggaa  gagaccagc  ccgagctcg  1200
cacctcccc  gcctctctc  tcccagctg  agatgccac  cctgctcct  cttgctttc  1260
ccgggggag  aagggggtt  tggtcgggg  gctggggta  aggtttggg  agggggaag  1320
gaaattttt  tttttgaac  cctgtgtcc  ttttgcata  gattaaagg  aggaaaagt  1380
aagtgtg  1387



<210> 2536
<211> 328
<212> PRT
<213> Homo sapiens
<308> P18065
<400> 2536

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
  1               5                  10                  15
Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
             20                  25                  30
Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
         35                  40                  45
Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
     50                  55                  60
Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
 65                  70                  75                  80
Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                 85                  90                  95
Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
             100                105                110
Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
         115                120                125
Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
     130                135                140
Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
 145                150                155                160
Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                 165                170                175
Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
             180                185                190
Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
         195                200                205
Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
     210                215                220
Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
 225                230                235                240
Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                 245                250                255
Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
             260                265                270
Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
         275                280                285
Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
     290                295                300
Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
 305                310                315                320
Gly Val His Thr Gln Arg Met Gln 
                 325



<210> 2537
<211> 1482
<212> DNA
<213> Rattus norvegicus
<308> J04486
<400> 2537

gatcacagg  ttggacact  cattctttc  aactcccca  ctaaaagtg  ccttaacta  60
ttactagac  gattggctg  agacctagc  cccaaggga  gatttggcc  gggtgatgc  120
tggcccact  agaggacac  agtgctttt  ccccttagc  gcattgtcc  ggaaatcaa  180
acgacaaaa  gcgtctccc  cgctcgcca  ggccgtgcc  cctgcccgc  agctcgccg  240
gctacggtt  cccactagc  aacatgctg  cgagattgg  cggccccgc  ctgccgctg  300
tcctgccgt  gctgctctt  ctgctgctg  tgggcgcgg  cggttgcgg  cctggggtg  360
gcgccgagg  gctgttccg  tgcccaccc  gcacgcccg  gcgtctggc  gcctgcgga  420
ccccacccg  cgcgccctg  gccgagctg  tgcgagagc  cggctgcgg  tgctgctcc  480
tgtgcgcac  acaggaggg  gaagcttgc  gcgtctaca  cccgcgctg  gcccagacg  540
tacgctgtt  ccccaaccc  ggctccgag  tgcccctga  ggcactggt  accggcgcg  600
gtacctgtg  aaagagacg  gtgggcgcc  ccccacagc  ggttgcaga  agtgaggat  660
accactcgg  gggaggcct  gtggagaac  atgtggacg  aaccatgaa  atgttagga  720
gcagcagtg  tggccggaa  ccccctaag  caggcatga  ggaactggc  gtgttccgg  780
agaaggtca  cgagcagca  cggcagatg  gcaaaggtg  caaacacct  agcctggag  840
agcccaaga  gctgcgccc  cctcctgcc  ggacccctt  ccagcagga  ctggaccag  900
tcctggagc  catctccac  atgcgcctt  cggatgatc  gggtcctct  gaacatctc  960
actccctgc  tatccccaa  tgtgacaag  atggcctgt  caacctcaa  cagtgcaag  1020
tgtctctga  tggacagcg  ggggagtgc  ggtgtgtga  ccccaatac  gggaagcca  1080
tccagggag  tcccaccat  cggggagac  ccgagtgcc  tctcttcta  aacgagcag  1140
aggagaatg  tggggttca  gcccaaagg  tgcagtaaa  cacagccag  cggtgcctg  1200
cttccccac  ccaaacacc  gcagaaatg  agggtgtca  ggtgatggg  gtggaggat  1260
tcccagttt  gacacatgt  tttatattt  gaaagagac  aacactgag  tcagaagcc  1320
ccctgcgcc  cccagtggc  gttaacctg  acctctgtt  ctgcttcta  tagagaggg  1380
ggtggcact  gggatactg  gtacaggct  gggaatggg  aaagaaatt  ttatttttg  1440
acccctgtg  ctcttttac  taagattaa  ggaaggaaa  at  1482



<210> 2538
<211> 304
<212> PRT
<213> Rattus norvegicus
<308> P12843
<400> 2538

Met Leu Pro Arg Leu Gly Gly Pro Ala Leu Pro Leu Leu Leu Pro Ser 
  1               5                  10                  15
Leu Leu Leu Leu Leu Leu Leu Gly Ala Gly Gly Cys Gly Pro Gly Val 
             20                  25                  30
Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu 
         35                  40                  45
Ala Ala Cys Gly Pro Pro Pro Asp Ala Pro Cys Ala Glu Leu Val Arg 
     50                  55                  60
Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Gln Glu Gly Glu 
 65                  70                  75                  80
Ala Cys Gly Val Tyr Ile Pro Arg Cys Ala Gln Thr Leu Arg Cys Tyr 
                 85                  90                  95
Pro Asn Pro Gly Ser Glu Leu Pro Leu Lys Ala Leu Val Thr Gly Ala 
             100                105                110
Gly Thr Cys Glu Lys Arg Arg Val Gly Ala Thr Pro Gln Gln Val Ala 
         115                120                125
Asp Ser Glu Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val 
     130                135                140
Asp Gly Thr Met Asn Met Leu Gly Gly Ser Ser Ala Gly Arg Lys Pro 
 145                150                155                160
Pro Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Asn 
                 165                170                175
Glu Gln His Arg Gln Met Gly Lys Gly Ala Lys His Leu Ser Leu Glu 
             180                185                190
Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln Gln 
         195                200                205
Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro Asp 
     210                215                220
Asp Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn Cys 
 225                230                235                240
Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu Asn 
                 245                250                255
Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys Pro 
             260                265                270
Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu Phe 
         275                280                285
Tyr Asn Glu Gln Gln Glu Asn Asp Gly Val His Ala Gln Arg Val Gln 
     290                295                300



<210> 2539
<211> 1387
<212> DNA
<213> Homo sapiens
<308> M35410
<400> 2539

gtgccacct  cccgcccgc  cgctcgctc  ctcgcccgc  gcgccgcgc  gccgaccgc  60
agcatgctg  cgagagtgg  ctgccccgc  ctgccgctg  cgccgccgc  gctgctgcc  120
ctgctgccg  tgctgctgc  gctactggg  gcgagtggc  gcggcggcg  ggcgcgcgc  180
gaggtgctg  tccgctgcc  gccctgcac  cccgagcgc  tggccgcct  cgggccccc  240
ccggttgcg  cgcccgccg  ggtggccgc  gtggccgga  gcgcccgca  gccatgcgc  300
gagctcgtc  gggagccgg  ctgcggctg  tgctcggtg  gcgcccggc  ggagggcga  360
gcgtgcggc  tctacaccc  gcgctgcgg  caggggctg  gctgctatc  ccacccggg  420
tccgagctg  ccctgcagg  gctggtcat  ggcgagggc  cttgtgaga  gcgccggga  480
gccgagtat  gcgccagcc  ggagcaggt  gcagacaat  gcgatgacc  ctcagaagg  540
ggcctggtg  agaaccacg  ggacagcac  atgaacatg  tgggcgggg  aggcagtgc  600
ggccggaag  ccctcaagt  gggtatgaa  gagctggcc  tgttccggg  gaaggtcac  660
gagcagcac  ggcagatgg  caagggtgg  aagcatcac  ttggcctgg  ggagcccaa  720
aagctgcga  caccccctg  caggactcc  tgccaacag  aactggacc  ggtcctgga  780
cggatctcc  ccatgcgcc  tccggatga  cggggccct  tggagcacc  ctactccct  840
cacatcccc  actgtgaca  gcatggcct  tacaacctc  aacagtgca  gatgtctct  900
aacgggcag  gtggggagt  ctggtgtgt  aaccccaac  ccgggaagc  gatccaggg  960
gcccccacc  tccgggggg  ccccgagtg  catctcttc  acaatgagc  gcaggaggc  1020
cgcggggtg  acacccagc  gatgcagta  accgcagcc  gccggtgcc  ggcgcccct  1080
ccccccgcc  ctctccaaa  accggcaga  aacggagag  gcttgggtg  tgggtgctg  1140
aggattttc  agttctgac  cacgtattt  tatatggaa  gagaccagc  ccgagctcg  1200
cacctcccc  gcctctctc  tcccagctg  agatgccac  cctgctcct  cttgctttc  1260
ccgggggag  aagggggtt  tggtcgggg  gctggggta  aggtttggg  agggggaag  1320
gaaattttt  tttttgaac  cctgtgtcc  ttttgcata  gattaaagg  aggaaaagt  1380
aagtgtg  1387



<210> 2540
<211> 328
<212> PRT
<213> Homo sapiens
<308> P18065
<400> 2540

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
  1               5                  10                  15
Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
             20                  25                  30
Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
         35                  40                  45
Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
     50                  55                  60
Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
 65                  70                  75                  80
Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                 85                  90                  95
Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
             100                105                110
Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
         115                120                125
Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
     130                135                140
Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
 145                150                155                160
Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                 165                170                175
Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
             180                185                190
Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
         195                200                205
Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
     210                215                220
Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
 225                230                235                240
Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                 245                250                255
Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
             260                265                270
Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
         275                280                285
Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
     290                295                300
Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
 305                310                315                320
Gly Val His Thr Gln Arg Met Gln 
                 325



<210> 2541
<211> 1602
<212> DNA
<213> Rattus norvegicus
<308> J04503
<400> 2541

tgcccggcc  ccgtcgcca  cgccgcccc  gccgaccga  ggacccgcc  gcccgcggc  60
gctccggat  tagaggatc  agtcataat  ggagcattt  tagacaagc  aaagatgga  120
aagcataat  cccagggcc  ggggaacgg  ttgcgatac  gcctaagca  catgcaagg  180
tggcgagtt  aaatggagg  tgcacatac  gctgtgatc  gtttgccaa  tggacttga  240
acatggtca  tctttgctg  atatgatgg  catgctggt  ctcaggttg  caaatactg  300
tgtgagcac  tgttagatc  catcaccaa  aaccaggat  ttaaaggct  tgcaggagc  360
ccctctgtg  aaaacgtaa  gaacggaat  agaacaggt  ttctggaga  tgatgaaca  420
atgagagtt  tgtcagaga  gaaacacgg  gcagataga  gtgggtcaa  agctgtggg  480
gtcttaatt  ctccccaac  tacttattt  attaactgt  gggactcaa  aggtttact  540
tgtagaaat  gaaaagttc  cttcttcac  caagaccat  aaccaagta  tcctctgga  600
aaagaacga  ttcagaatg  agggggctc  gtgatgatt  agcgtgtca  tggctctct  660
gctgtatca  gagctcttg  ggattttga  tacaaatgt  tccatggaa  aggtcccac  720
gagcagctt  tctcgccag  gcctgaagt  catgatatt  aaaggtctg  agaagatga  780
cagttcatc  ttcttgcat  tgatggcat  tgggacgtc  tgggcaacg  agagctctg  840
gactttgtg  gatccagac  tgaagtcac  gatgacctt  agaaagttt  caatgaagt  900
gtcgacacc  gtttgtata  gggaagtcg  gacaacatg  gtgtgattt  gatctgctt  960
ccaaacgcg  ctaaagtct  agcagaggc  gtgaagaag  aggcagagc  ggacaagta  1020
ctggagaac  gagtagaag  aatcataaa  aagcagggg  aaggcgtcc  tgacttagt  1080
catgtgatg  gcacgttag  cagtgagaa  atccccagc  tcccaccag  gggtgaact  1140
gcaagcaag  ggaatgtaa  tgaagccgt  tacaataga  tgaaccctt  caaaaacga  1200
gacactgat  ctgcgtcaa  tgatgatat  tggtaaagc  gctcatcta  ccatggttt  1260
acctttgcc  ggaagagag  gagagatca  cgcatcctt  ctgagcctt  aacatccat  1320
accgactta  ggaaggggt  cgacatggg  gagggacta  agcttcagc  atggaacag  1380
cagcccaga  tggattttt  tttttattg  aaatttgag  cttatgtaa  cgtgatttc  1440
aaccgtaat  catgttgta  atcagactc  agcaatttt  gttgtatga  tttggtttt  1500
tgtaaagtg  aattgtcct  gtacaaagt  ctcatattt  attatgaac  gctttaaaa  1560
cactatcaa  gataaagga  atttggctt  ttgtgtggc  ca  1602



<210> 2542
<211> 382
<212> PRT
<213> Rattus norvegicus
<308> P20650
<400> 2542

Met Gly Ala Phe Leu Asp Lys Pro Lys Met Glu Lys His Asn Ala Gln 
  1               5                  10                  15
Gly Gln Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
             20                  25                  30
Arg Val Glu Met Glu Asp Ala His Thr Ala Val Ile Gly Leu Pro Ser 
         35                  40                  45
Gly Leu Glu Thr Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
     50                  55                  60
Ser Gln Val Ala Lys Tyr Cys Cys Glu His Leu Leu Asp His Ile Thr 
 65                  70                  75                  80
Asn Asn Gln Asp Phe Lys Gly Ser Ala Gly Ala Pro Ser Val Glu Asn 
                 85                  90                  95
Val Lys Asn Gly Ile Arg Thr Gly Phe Leu Glu Ile Asp Glu His Met 
             100                105                110
Arg Val Met Ser Glu Lys Lys His Gly Ala Asp Arg Ser Gly Ser Thr 
         115                120                125
Ala Val Gly Val Leu Ile Ser Pro Gln His Thr Tyr Phe Ile Asn Cys 
     130                135                140
Gly Asp Ser Arg Gly Leu Leu Cys Arg Asn Arg Lys Val His Phe Phe 
 145                150                155                160
Thr Gln Asp His Lys Pro Ser Asn Pro Leu Glu Lys Glu Arg Ile Gln 
                 165                170                175
Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val Asn Gly Ser Leu Ala 
             180                185                190
Val Ser Arg Ala Leu Gly Asp Phe Asp Tyr Lys Cys Val His Gly Lys 
         195                200                205
Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro Glu Val His Asp Ile 
     210                215                220
Glu Arg Ser Glu Glu Asp Asp Gln Phe Ile Ile Leu Ala Cys Asp Gly 
 225                230                235                240
Ile Trp Asp Val Met Gly Asn Glu Glu Leu Cys Asp Phe Val Arg Ser 
                 245                250                255
Arg Leu Glu Val Thr Asp Asp Leu Glu Lys Val Cys Asn Glu Val Val 
             260                265                270
Asp Thr Cys Leu Tyr Lys Gly Ser Arg Asp Asn Met Ser Val Ile Leu 
         275                280                285
Ile Cys Phe Pro Asn Ala Pro Lys Val Ser Ala Glu Ala Val Lys Lys 
     290                295                300
Glu Ala Glu Leu Asp Lys Tyr Leu Glu Asn Arg Val Glu Glu Ile Ile 
 305                310                315                320
Lys Lys Gln Gly Glu Gly Val Pro Asp Leu Val His Val Met Arg Thr 
                 325                330                335
Leu Ala Ser Glu Asn Ile Pro Ser Leu Pro Pro Gly Gly Glu Leu Ala 
             340                345                350
Ser Lys Arg Asn Val Ile Glu Ala Val Tyr Asn Arg Leu Asn Pro Tyr 
         355                360                365
Lys Asn Asp Asp Thr Asp Ser Ala Ser Thr Asp Asp Met Trp 
     370                375                380



<210> 2543
<211> 2346
<212> DNA
<213> Homo sapiens
<308> S87759
<400> 2543

cggaacgtg  ttggggagg  gggggtggg  gggactcta  acagctgag  cgcgaaagc  60
tgagtcctc  gctcttcct  ctccttctc  gggacccgc  ctctgcctc  ctctccaac  120
cccggatga  ctgagccgc  agggcgccg  cagccgggg  cccggacgc  gcccggctc  180
tcccctcct  cgccccttc  ccagcctga  ctggcccgc  gctgcagcg  tgacccctc  240
cccggctgc  gccgtcgcc  ccgcggtga  cccctcccc  gctgccgcc  ccgccgcct  300
ggccgacca  ggacctgcc  gcctgcggc  gctccggac  tagaggatc  agacataat  360
ggagcattt  tagacaagc  aaagatgga  aagcataat  cccaggggc  gggtaatgg  420
ttgcgatat  ggctaagca  catgcaagg  tggcgtgtt  aaatggagg  tgcacatac  480
gctgtgatc  gtttgccaa  tggacttga  tcgtggtca  tctttgctg  gtatgatgg  540
catgctggt  ctcaggttg  caaatactg  tgtgagcat  tgttagatc  catcaccaa  600
aaccaggat  ttaaagggt  tgcaggagc  ccttctgtg  aaaatgtaa  gaatggaat  660
agaacaggt  ttctggaga  tgatgaaca  atgagagtt  tgtcagaga  gaaacatgg  720
gcagataga  gtgggtcaa  agctgtagg  gtcttaatt  ctccccaac  tacttattt  780
attaactgt  gagactcaa  aggtttact  tgtaggaac  ggaaagttc  tttcttcac  840
caagatcac  aaccaagta  tccgctgga  aaagaacga  ttcagaatg  aggtggctc  900
gtaatgatt  agcgtgtga  tggctctct  gctgtatcg  gggcccttg  ggattttga  960
tacaaatgt  tccatggaa  aggtcctac  gagcagctt  tctcaccag  gcctgaagt  1020
catgatatt  aaagatctg  agaagatga  cagttcatt  tccttgcat  tgatggtat  1080
tgggatgtt  tgggaaatg  agagctctg  gattttgta  gatccagac  tgaagtcac  1140
gatgacctt  agaaagttt  caatgaagt  gtcgacacc  gtttgtata  gggaagtcg  1200
gacaacatg  gtgtgattt  gatctgttt  ccaaatgca  ccaaagtat  gccagaagc  1260
gtgaagaag  aggcagagt  ggacaagta  ctggaatgc  gagtagaag  aatcataaa  1320
aagcagggg  aaggcgtcc  cgacttagt  catgtgatg  gcacattag  gagtgagaa  1380
atccccagc  tcccaccag  gggtgaatt  gcaagcaag  ggaatgtta  tgaagccgt  1440
tacaataga  tgaatcctt  caaaaatga  gacactgac  ctacatcaa  agatgatat  1500
tggtaaaac  gctcatcta  ccatggagt  taccttcac  tccaaagga  agtacagct  1560
aactttgtt  aaactttta  catccatcc  caactttaa  gaaggggat  tgacatggg  1620
gagaatgat  acatcagag  acttcagca  tacaacagc  agcccagaa  tgatttttt  1680
ttttttttt  tttgtaaat  tgagactta  gtaagcgtg  tttcaaacc  taattcgtg  1740
tgtaaatca  actccagca  tttttgttg  atgattttg  ttttttgta  agtgtaatt  1800
tccttgtac  aaatgctca  atttaatta  gaactgctt  aaatcacta  caaagttac  1860
agaaatgtt  ggcttattg  gtgatgcaa  agatatata  ccctttcaa  tcatgttgt  1920
tttggactt  gggttggaa  agggagagc  gcagccatg  cagctacac  ctcaaatgt  1980
cagatgatt  tggaaaata  cctcaaaat  ttacaaagc  gaacatcca  ggagttatt  2040
aaaactatc  taaatgttc  tggtagggg  gttggcatt  ttgataaag  cagtccctt  2100
atttaactg  ctttcagga  gttccttcg  tgtttccat  agtattgca  gtaataata  2160
agtgtgttc  ataagaatc  caatcttgg  gctaaatgc  ttgtttctt  gcacctctt  2220
tcaagtcct  acatttaat  actaattga  aagcagcag  ttcctacat  tagtaggaa  2280
ctgccacat  tttgctatc  tgattggct  ggcctgctg  tgttcctag  aagatattc  2340
gaattc  2346



<210> 2544
<211> 382
<212> PRT
<213> Homo sapiens
<308> P35813
<400> 2544

Met Gly Ala Phe Leu Asp Lys Pro Lys Met Glu Lys His Asn Ala Gln 
  1               5                  10                  15
Gly Gln Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
             20                  25                  30
Arg Val Glu Met Glu Asp Ala His Thr Ala Val Ile Gly Leu Pro Ser 
         35                  40                  45
Gly Leu Glu Ser Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
     50                  55                  60
Ser Gln Val Ala Lys Tyr Cys Cys Glu His Leu Leu Asp His Ile Thr 
 65                  70                  75                  80
Asn Asn Gln Asp Phe Lys Gly Ser Ala Gly Ala Pro Ser Val Glu Asn 
                 85                  90                  95
Val Lys Asn Gly Ile Arg Thr Gly Phe Leu Glu Ile Asp Glu His Met 
             100                105                110
Arg Val Met Ser Glu Lys Lys His Gly Ala Asp Arg Ser Gly Ser Thr 
         115                120                125
Ala Val Gly Val Leu Ile Ser Pro Gln His Thr Tyr Phe Ile Asn Cys 
     130                135                140
Gly Asp Ser Arg Gly Leu Leu Cys Arg Asn Arg Lys Val His Phe Phe 
 145                150                155                160
Thr Gln Asp His Lys Pro Ser Asn Pro Leu Glu Lys Glu Arg Ile Gln 
                 165                170                175
Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val Asn Gly Ser Leu Ala 
             180                185                190
Val Ser Arg Ala Leu Gly Asp Phe Asp Tyr Lys Cys Val His Gly Lys 
         195                200                205
Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro Glu Val His Asp Ile 
     210                215                220
Glu Arg Ser Glu Glu Asp Asp Gln Phe Ile Ile Leu Ala Cys Asp Gly 
 225                230                235                240
Ile Trp Asp Val Met Gly Asn Glu Glu Leu Cys Asp Phe Val Arg Ser 
                 245                250                255
Arg Leu Glu Val Thr Asp Asp Leu Glu Lys Val Cys Asn Glu Val Val 
             260                265                270
Asp Thr Cys Leu Tyr Lys Gly Ser Arg Asp Asn Met Ser Val Ile Leu 
         275                280                285
Ile Cys Phe Pro Asn Ala Pro Lys Val Ser Pro Glu Ala Val Lys Lys 
     290                295                300
Glu Ala Glu Leu Asp Lys Tyr Leu Glu Cys Arg Val Glu Glu Ile Ile 
 305                310                315                320
Lys Lys Gln Gly Glu Gly Val Pro Asp Leu Val His Val Met Arg Thr 
                 325                330                335
Leu Ala Ser Glu Asn Ile Pro Ser Leu Pro Pro Gly Gly Glu Leu Ala 
             340                345                350
Ser Lys Arg Asn Val Ile Glu Ala Val Tyr Asn Arg Leu Asn Pro Tyr 
         355                360                365
Lys Asn Asp Asp Thr Asp Ser Thr Ser Thr Asp Asp Met Trp 
     370                375                380



<210> 2545
<211> 1602
<212> DNA
<213> Rattus norvegicus
<308> J04503
<400> 2545

tgcccggcc  ccgtcgcca  cgccgcccc  gccgaccga  ggacccgcc  gcccgcggc  60
gctccggat  tagaggatc  agtcataat  ggagcattt  tagacaagc  aaagatgga  120
aagcataat  cccagggcc  ggggaacgg  ttgcgatac  gcctaagca  catgcaagg  180
tggcgagtt  aaatggagg  tgcacatac  gctgtgatc  gtttgccaa  tggacttga  240
acatggtca  tctttgctg  atatgatgg  catgctggt  ctcaggttg  caaatactg  300
tgtgagcac  tgttagatc  catcaccaa  aaccaggat  ttaaaggct  tgcaggagc  360
ccctctgtg  aaaacgtaa  gaacggaat  agaacaggt  ttctggaga  tgatgaaca  420
atgagagtt  tgtcagaga  gaaacacgg  gcagataga  gtgggtcaa  agctgtggg  480
gtcttaatt  ctccccaac  tacttattt  attaactgt  gggactcaa  aggtttact  540
tgtagaaat  gaaaagttc  cttcttcac  caagaccat  aaccaagta  tcctctgga  600
aaagaacga  ttcagaatg  agggggctc  gtgatgatt  agcgtgtca  tggctctct  660
gctgtatca  gagctcttg  ggattttga  tacaaatgt  tccatggaa  aggtcccac  720
gagcagctt  tctcgccag  gcctgaagt  catgatatt  aaaggtctg  agaagatga  780
cagttcatc  ttcttgcat  tgatggcat  tgggacgtc  tgggcaacg  agagctctg  840
gactttgtg  gatccagac  tgaagtcac  gatgacctt  agaaagttt  caatgaagt  900
gtcgacacc  gtttgtata  gggaagtcg  gacaacatg  gtgtgattt  gatctgctt  960
ccaaacgcg  ctaaagtct  agcagaggc  gtgaagaag  aggcagagc  ggacaagta  1020
ctggagaac  gagtagaag  aatcataaa  aagcagggg  aaggcgtcc  tgacttagt  1080
catgtgatg  gcacgttag  cagtgagaa  atccccagc  tcccaccag  gggtgaact  1140
gcaagcaag  ggaatgtaa  tgaagccgt  tacaataga  tgaaccctt  caaaaacga  1200
gacactgat  ctgcgtcaa  tgatgatat  tggtaaagc  gctcatcta  ccatggttt  1260
acctttgcc  ggaagagag  gagagatca  cgcatcctt  ctgagcctt  aacatccat  1320
accgactta  ggaaggggt  cgacatggg  gagggacta  agcttcagc  atggaacag  1380
cagcccaga  tggattttt  tttttattg  aaatttgag  cttatgtaa  cgtgatttc  1440
aaccgtaat  catgttgta  atcagactc  agcaatttt  gttgtatga  tttggtttt  1500
tgtaaagtg  aattgtcct  gtacaaagt  ctcatattt  attatgaac  gctttaaaa  1560
cactatcaa  gataaagga  atttggctt  ttgtgtggc  ca  1602



<210> 2546
<211> 382
<212> PRT
<213> Rattus norvegicus
<308> P20650
<400> 2546

Met Gly Ala Phe Leu Asp Lys Pro Lys Met Glu Lys His Asn Ala Gln 
  1               5                  10                  15
Gly Gln Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
             20                  25                  30
Arg Val Glu Met Glu Asp Ala His Thr Ala Val Ile Gly Leu Pro Ser 
         35                  40                  45
Gly Leu Glu Thr Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
     50                  55                  60
Ser Gln Val Ala Lys Tyr Cys Cys Glu His Leu Leu Asp His Ile Thr 
 65                  70                  75                  80
Asn Asn Gln Asp Phe Lys Gly Ser Ala Gly Ala Pro Ser Val Glu Asn 
                 85                  90                  95
Val Lys Asn Gly Ile Arg Thr Gly Phe Leu Glu Ile Asp Glu His Met 
             100                105                110
Arg Val Met Ser Glu Lys Lys His Gly Ala Asp Arg Ser Gly Ser Thr 
         115                120                125
Ala Val Gly Val Leu Ile Ser Pro Gln His Thr Tyr Phe Ile Asn Cys 
     130                135                140
Gly Asp Ser Arg Gly Leu Leu Cys Arg Asn Arg Lys Val His Phe Phe 
 145                150                155                160
Thr Gln Asp His Lys Pro Ser Asn Pro Leu Glu Lys Glu Arg Ile Gln 
                 165                170                175
Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val Asn Gly Ser Leu Ala 
             180                185                190
Val Ser Arg Ala Leu Gly Asp Phe Asp Tyr Lys Cys Val His Gly Lys 
         195                200                205
Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro Glu Val His Asp Ile 
     210                215                220
Glu Arg Ser Glu Glu Asp Asp Gln Phe Ile Ile Leu Ala Cys Asp Gly 
 225                230                235                240
Ile Trp Asp Val Met Gly Asn Glu Glu Leu Cys Asp Phe Val Arg Ser 
                 245                250                255
Arg Leu Glu Val Thr Asp Asp Leu Glu Lys Val Cys Asn Glu Val Val 
             260                265                270
Asp Thr Cys Leu Tyr Lys Gly Ser Arg Asp Asn Met Ser Val Ile Leu 
         275                280                285
Ile Cys Phe Pro Asn Ala Pro Lys Val Ser Ala Glu Ala Val Lys Lys 
     290                295                300
Glu Ala Glu Leu Asp Lys Tyr Leu Glu Asn Arg Val Glu Glu Ile Ile 
 305                310                315                320
Lys Lys Gln Gly Glu Gly Val Pro Asp Leu Val His Val Met Arg Thr 
                 325                330                335
Leu Ala Ser Glu Asn Ile Pro Ser Leu Pro Pro Gly Gly Glu Leu Ala 
             340                345                350
Ser Lys Arg Asn Val Ile Glu Ala Val Tyr Asn Arg Leu Asn Pro Tyr 
         355                360                365
Lys Asn Asp Asp Thr Asp Ser Ala Ser Thr Asp Asp Met Trp 
     370                375                380



<210> 2547
<211> 2346
<212> DNA
<213> Homo sapiens
<308> S87759
<400> 2547

cggaacgtg  ttggggagg  gggggtggg  gggactcta  acagctgag  cgcgaaagc  60
tgagtcctc  gctcttcct  ctccttctc  gggacccgc  ctctgcctc  ctctccaac  120
cccggatga  ctgagccgc  agggcgccg  cagccgggg  cccggacgc  gcccggctc  180
tcccctcct  cgccccttc  ccagcctga  ctggcccgc  gctgcagcg  tgacccctc  240
cccggctgc  gccgtcgcc  ccgcggtga  cccctcccc  gctgccgcc  ccgccgcct  300
ggccgacca  ggacctgcc  gcctgcggc  gctccggac  tagaggatc  agacataat  360
ggagcattt  tagacaagc  aaagatgga  aagcataat  cccaggggc  gggtaatgg  420
ttgcgatat  ggctaagca  catgcaagg  tggcgtgtt  aaatggagg  tgcacatac  480
gctgtgatc  gtttgccaa  tggacttga  tcgtggtca  tctttgctg  gtatgatgg  540
catgctggt  ctcaggttg  caaatactg  tgtgagcat  tgttagatc  catcaccaa  600
aaccaggat  ttaaagggt  tgcaggagc  ccttctgtg  aaaatgtaa  gaatggaat  660
agaacaggt  ttctggaga  tgatgaaca  atgagagtt  tgtcagaga  gaaacatgg  720
gcagataga  gtgggtcaa  agctgtagg  gtcttaatt  ctccccaac  tacttattt  780
attaactgt  gagactcaa  aggtttact  tgtaggaac  ggaaagttc  tttcttcac  840
caagatcac  aaccaagta  tccgctgga  aaagaacga  ttcagaatg  aggtggctc  900
gtaatgatt  agcgtgtga  tggctctct  gctgtatcg  gggcccttg  ggattttga  960
tacaaatgt  tccatggaa  aggtcctac  gagcagctt  tctcaccag  gcctgaagt  1020
catgatatt  aaagatctg  agaagatga  cagttcatt  tccttgcat  tgatggtat  1080
tgggatgtt  tgggaaatg  agagctctg  gattttgta  gatccagac  tgaagtcac  1140
gatgacctt  agaaagttt  caatgaagt  gtcgacacc  gtttgtata  gggaagtcg  1200
gacaacatg  gtgtgattt  gatctgttt  ccaaatgca  ccaaagtat  gccagaagc  1260
gtgaagaag  aggcagagt  ggacaagta  ctggaatgc  gagtagaag  aatcataaa  1320
aagcagggg  aaggcgtcc  cgacttagt  catgtgatg  gcacattag  gagtgagaa  1380
atccccagc  tcccaccag  gggtgaatt  gcaagcaag  ggaatgtta  tgaagccgt  1440
tacaataga  tgaatcctt  caaaaatga  gacactgac  ctacatcaa  agatgatat  1500
tggtaaaac  gctcatcta  ccatggagt  taccttcac  tccaaagga  agtacagct  1560
aactttgtt  aaactttta  catccatcc  caactttaa  gaaggggat  tgacatggg  1620
gagaatgat  acatcagag  acttcagca  tacaacagc  agcccagaa  tgatttttt  1680
ttttttttt  tttgtaaat  tgagactta  gtaagcgtg  tttcaaacc  taattcgtg  1740
tgtaaatca  actccagca  tttttgttg  atgattttg  ttttttgta  agtgtaatt  1800
tccttgtac  aaatgctca  atttaatta  gaactgctt  aaatcacta  caaagttac  1860
agaaatgtt  ggcttattg  gtgatgcaa  agatatata  ccctttcaa  tcatgttgt  1920
tttggactt  gggttggaa  agggagagc  gcagccatg  cagctacac  ctcaaatgt  1980
cagatgatt  tggaaaata  cctcaaaat  ttacaaagc  gaacatcca  ggagttatt  2040
aaaactatc  taaatgttc  tggtagggg  gttggcatt  ttgataaag  cagtccctt  2100
atttaactg  ctttcagga  gttccttcg  tgtttccat  agtattgca  gtaataata  2160
agtgtgttc  ataagaatc  caatcttgg  gctaaatgc  ttgtttctt  gcacctctt  2220
tcaagtcct  acatttaat  actaattga  aagcagcag  ttcctacat  tagtaggaa  2280
ctgccacat  tttgctatc  tgattggct  ggcctgctg  tgttcctag  aagatattc  2340
gaattc  2346



<210> 2548
<211> 382
<212> PRT
<213> Homo sapiens
<308> P35813
<400> 2548

Met Gly Ala Phe Leu Asp Lys Pro Lys Met Glu Lys His Asn Ala Gln 
  1               5                  10                  15
Gly Gln Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
             20                  25                  30
Arg Val Glu Met Glu Asp Ala His Thr Ala Val Ile Gly Leu Pro Ser 
         35                  40                  45
Gly Leu Glu Ser Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
     50                  55                  60
Ser Gln Val Ala Lys Tyr Cys Cys Glu His Leu Leu Asp His Ile Thr 
 65                  70                  75                  80
Asn Asn Gln Asp Phe Lys Gly Ser Ala Gly Ala Pro Ser Val Glu Asn 
                 85                  90                  95
Val Lys Asn Gly Ile Arg Thr Gly Phe Leu Glu Ile Asp Glu His Met 
             100                105                110
Arg Val Met Ser Glu Lys Lys His Gly Ala Asp Arg Ser Gly Ser Thr 
         115                120                125
Ala Val Gly Val Leu Ile Ser Pro Gln His Thr Tyr Phe Ile Asn Cys 
     130                135                140
Gly Asp Ser Arg Gly Leu Leu Cys Arg Asn Arg Lys Val His Phe Phe 
 145                150                155                160
Thr Gln Asp His Lys Pro Ser Asn Pro Leu Glu Lys Glu Arg Ile Gln 
                 165                170                175
Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val Asn Gly Ser Leu Ala 
             180                185                190
Val Ser Arg Ala Leu Gly Asp Phe Asp Tyr Lys Cys Val His Gly Lys 
         195                200                205
Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro Glu Val His Asp Ile 
     210                215                220
Glu Arg Ser Glu Glu Asp Asp Gln Phe Ile Ile Leu Ala Cys Asp Gly 
 225                230                235                240
Ile Trp Asp Val Met Gly Asn Glu Glu Leu Cys Asp Phe Val Arg Ser 
                 245                250                255
Arg Leu Glu Val Thr Asp Asp Leu Glu Lys Val Cys Asn Glu Val Val 
             260                265                270
Asp Thr Cys Leu Tyr Lys Gly Ser Arg Asp Asn Met Ser Val Ile Leu 
         275                280                285
Ile Cys Phe Pro Asn Ala Pro Lys Val Ser Pro Glu Ala Val Lys Lys 
     290                295                300
Glu Ala Glu Leu Asp Lys Tyr Leu Glu Cys Arg Val Glu Glu Ile Ile 
 305                310                315                320
Lys Lys Gln Gly Glu Gly Val Pro Asp Leu Val His Val Met Arg Thr 
                 325                330                335
Leu Ala Ser Glu Asn Ile Pro Ser Leu Pro Pro Gly Gly Glu Leu Ala 
             340                345                350
Ser Lys Arg Asn Val Ile Glu Ala Val Tyr Asn Arg Leu Asn Pro Tyr 
         355                360                365
Lys Asn Asp Asp Thr Asp Ser Thr Ser Thr Asp Asp Met Trp 
     370                375                380



<210> 2549
<211> 2153
<212> DNA
<213> Rattus norvegicus
<308> J04791
<400> 2549

cggccgggt  cgccttggg  tttagtggc  gcttctcca  gggtccagc  agccgcttc  60
ctgtgctgt  aggagacag  attcagagt  gaccttgtg  gagctggcc  taatttaat  120
ccatctcta  gttttctgt  ggcacatcg  gaaccaacc  tgggcagct  tactaagga  180
gagtttgac  gccatatcc  cgatgaagg  ttcactgct  aggacattc  ggaccaaaa  240
atcaatgaa  tttcttcct  tgatgataa  gatgctttc  atgttgcgg  cctcggaga  300
gttctaaag  agcatctga  gtggctgaa  gctcttccc  gtgttactc  cttctatgc  360
gtcaagtgt  atgacagca  agccatagt  agcaccctg  ctgccattg  gacaggatt  420
gattgtgca  gcaagactg  aatacagtt  gtgcagggg  ttggggtgc  tccagagag  480
attatctat  caaatcctt  taagcaagt  tctcagatc  agtatgctg  cagtaatgg  540
gtccagatg  tgacttttg  cagtgaaat  gagttgatg  aagttgcca  agcacatcc  600
aaggcaaag  tggttttgc  gattgccac  gatgattcc  aagcagttt  tcggctcag  660
gttaagttt  gtgccacac  gaaaaccag  aggcttctc  tggaacggg  aaaagagct  720
aatattgat  tcattggtg  cagcttcca  gtgggcagt  ggtgtactg  ccctgagac  780
ttcgtgcag  cagtgtcag  tgcccgctg  gtctttgac  tgggaacag  agttggttt  840
agcatgtat  tgcttgaca  tggtggtgg  tttcctggg  ctgaagaca  gaagcttaa  900
tttgaggag  tcaccagtg  aatcaaccc  gctctggac  agtacttcc  atcggactc  960
ggagtgaga  tcatagctg  gccaggcag  tactacgtc  catcagctt  cacacttgc  1020
gtgaatatc  ttgccaaaa  aaccgtgtg  aaggagcag  ccggctcgg  cgatgaaga  1080
gagtcaaac  agcaaactt  gatgtatta  gtgaatgat  gagtgtatg  gtcatttaa  1140
tgcattctt  atgaccatg  acatgtgaa  gccctgctg  agaagagac  caagccaga  1200
gagaagtat  actcatcca  catctgggg  ccaacatgt  atggccttg  tcggatcgt  1260
gagcgctgt  gcctgcctg  aatgcatgt  ggtgattgg  tgctgtttg  gaacatggg  1320
gcatacact  ttgctgctg  ttctacttt  aatgggttc  agaggccaa  catctacta  1380
gtaatgtca  ggtcaatgt  gcaactcat  aagcaaatc  agagccatg  cttcccgcc  1440
gaagtggag  agcaggatg  tggcactct  cccatgtct  gtgcccagg  gagcgggat  1500
gaccgtcac  ctgcagcct  tgcttctgc  agtatcaat  tatagatgc  attcttgta  1560
ctcttacct  caagtttag  ttgagttca  ggcatttgg  gggaccatt  aacttaatt  1620
ctgctagtt  ggaatgtct  tgtaagagt  gggttggca  caatgcagt  tggaaagac  1680
aggagatgg  ggtcacact  actgtgttc  tatggaaac  ttgaatatt  tatatggat  1740
tttattcac  tttcagacc  gatactaat  agtgcccct  ggctgctga  caagcattt  1800
tagcttgta  attggcaga  tgggctaaa  gcttatgtt  tgacccatt  tgaaaataa  1860
gtatcttga  atgattgga  attggagaa  gtgtgcaag  atcccttac  gaaggcaca  1920
acttctgca  aggctgtgt  ttacagcag  gagtctagc  cagcagaga  gtggatgat  1980
caaagctgt  ccccctctg  acagcatca  tgtgcttag  ccatctcaa  tgtttactg  2040
gaacttggt  cccaaagtc  cttaagagt  tcatctgcc  agtggcctc  tgacttggc  2100
acttcctaa  gagagggca  ctgaggctc  ttgaacctt  cctgcagaa  ccc  2153



<210> 2550
<211> 461
<212> PRT
<213> Rattus norvegicus
<308> NP_036747
<400> 2550

Met Gly Ser Phe Thr Lys Glu Glu Phe Asp Cys His Ile Leu Asp Glu 
  1               5                  10                  15
Gly Phe Thr Ala Lys Asp Ile Leu Asp Gln Lys Ile Asn Glu Val Ser 
             20                  25                  30
Ser Ser Asp Asp Lys Asp Ala Phe Tyr Val Ala Asp Leu Gly Asp Val 
         35                  40                  45
Leu Lys Lys His Leu Arg Trp Leu Lys Ala Leu Pro Arg Val Thr Pro 
     50                  55                  60
Phe Tyr Ala Val Lys Cys Asn Asp Ser Arg Ala Ile Val Ser Thr Leu 
 65                  70                  75                  80
Ala Ala Ile Gly Thr Gly Phe Asp Cys Ala Ser Lys Thr Glu Ile Gln 
                 85                  90                  95
Leu Val Gln Gly Leu Gly Val Pro Pro Glu Arg Ile Ile Tyr Ala Asn 
             100                105                110
Pro Cys Lys Gln Val Ser Gln Ile Lys Tyr Ala Ala Ser Asn Gly Val 
         115                120                125
Gln Met Met Thr Phe Asp Ser Glu Ile Glu Leu Met Lys Val Ala Arg 
     130                135                140
Ala His Pro Lys Ala Lys Leu Val Leu Arg Ile Ala Thr Asp Asp Ser 
 145                150                155                160
Lys Ala Val Cys Arg Leu Ser Val Lys Phe Gly Ala Thr Leu Lys Thr 
                 165                170                175
Ser Arg Leu Leu Leu Glu Arg Ala Lys Glu Leu Asn Ile Asp Val Ile 
             180                185                190
Gly Val Ser Phe His Val Gly Ser Gly Cys Thr Asp Pro Glu Thr Phe 
         195                200                205
Val Gln Ala Val Ser Asp Ala Arg Cys Val Phe Asp Met Gly Thr Glu 
     210                215                220
Val Gly Phe Ser Met Tyr Leu Leu Asp Ile Gly Gly Gly Phe Pro Gly 
 225                230                235                240
Ser Glu Asp Thr Lys Leu Lys Phe Glu Glu Ile Thr Ser Val Ile Asn 
                 245                250                255
Pro Ala Leu Asp Lys Tyr Phe Pro Ser Asp Ser Gly Val Arg Ile Ile 
             260                265                270
Ala Glu Pro Gly Arg Tyr Tyr Val Ala Ser Ala Phe Thr Leu Ala Val 
         275                280                285
Asn Ile Ile Ala Lys Lys Thr Val Trp Lys Glu Gln Thr Gly Ser Asp 
     290                295                300
Asp Glu Asp Glu Ser Asn Glu Gln Thr Leu Met Tyr Tyr Val Asn Asp 
 305                310                315                320
Gly Val Tyr Gly Ser Phe Asn Cys Ile Leu Tyr Asp His Ala His Val 
                 325                330                335
Lys Ala Leu Leu Gln Lys Arg Pro Lys Pro Asp Glu Lys Tyr Tyr Ser 
             340                345                350
Ser Ser Ile Trp Gly Pro Thr Cys Asp Gly Leu Asp Arg Ile Val Glu 
         355                360                365
Arg Cys Ser Leu Pro Glu Met His Val Gly Asp Trp Met Leu Phe Glu 
     370                375                380
Asn Met Gly Ala Tyr Thr Val Ala Ala Ala Ser Thr Phe Asn Gly Phe 
 385                390                395                400
Gln Arg Pro Asn Ile Tyr Tyr Val Met Ser Arg Ser Met Trp Gln Leu 
                 405                410                415
Met Lys Gln Ile Gln Ser His Gly Phe Pro Pro Glu Val Glu Glu Gln 
             420                425                430
Asp Val Gly Thr Leu Pro Met Ser Cys Ala Gln Glu Ser Gly Met Asp 
         435                440                445
Arg His Pro Ala Ala Cys Ala Ser Ala Ser Ile Asn Val 
     450                455                460



<210> 2551
<211> 2062
<212> DNA
<213> Homo sapiens
<308> NM_002539
<400> 2551

gtcagtccc  cctgtagcc  ccgccgccg  cgcccgccg  ccctctgcc  gcagctccg  60
cgccacctc  ggccggcgt  tccggcggg  gggagccag  cgctgacgg  cgcggcggg  120
gcggccgag  gctcctgcg  ctgcgactc  ggctccggc  tctgcgctt  cccatgggg  180
tggcctgcg  cgcctgggc  ctctgagat  gtcactgct  ttccaaggg  acacgcaga  240
ggatttgga  ttcctggag  gttgccttt  tgagaagct  gaaatattt  tttcaattc  300
atctcttag  tttccatag  aacatcaag  aatcatgaa  aactttggt  atgaagagt  360
tgactgcca  ttcctcgat  aaggtttta  tgccaagga  attctggac  agaaaatta  420
tgaagtttc  tcttctgat  ataaggatg  cttctatgt  gcagacctg  gagacattc  480
aaagaaaca  ctgaggtgg  taaaagctc  ccctcgtgt  acccccttt  atgcagtca  540
atgtaatga  agcaaagcc  tcgtgaaga  ccttgctgc  accgggaca  gatttgact  600
tgctagcaa  actgaaata  agttggtgc  gagtctggg  gtgcctcca  agaggatta  660
ctatgcaaa  ccttgtaaa  aagtatctc  aattaagta  gctgctaat  atggagtcc  720
gatgatgac  tttgatagt  aagttgagt  gatgaaagt  gccagagca  atcccaaag  780
aaagttggt  ttgcggatt  ccactgatg  ttccaaagc  gtctgtcgt  tcagtgtga  840
attcggtgc  acgctcaga  ccagcaggc  ccttttgga  cgggcgaaa  agctaaata  900
cgatgttgt  ggtgtcagc  tccatgtag  aagcggctg  accgatcct  agaccttcg  960
gcaggcaat  tctgatgcc  gctgtgttt  tgacatggg  gctgaggtt  gtttcagca  1020
gtatctgct  gatattggc  gtggctttc  tggatctga  gatgtgaaa  ttaaatttg  1080
agagatcac  ggcgtaatc  acccagcgt  ggacaaata  tttccgtca  actctggag  1140
gagaatcat  gctgagccc  gcagatact  tgttgcatc  gctttcacg  ttgcagtta  1200
tatcattgc  aagaaaatt  tattaaagg  acagacggg  tctgatgac  aagatgagt  1260
gagtgagca  acctttatg  attatgtga  tgatggcgt  tatggatca  ttaattgca  1320
actctatga  cacgcacat  taaagcccc  tctgcaaaa  agacctaaa  cagatgaga  1380
gtattattc  tccagcata  ggggaccaa  atgtgatgg  ctcgatcgg  ttgttgagc  1440
ctgtgacct  cctgaaatg  atgtgggtg  ttggatgct  tttgaaaac  tgggcgctt  1500
cactgttgc  gctgcctct  cgttcaatg  cttccagag  ccgacgatc  actatgtga  1560
gtcagggcc  gcgtggcaa  tcatgcagc  attccagaa  cccgacttc  cacccgaag  1620
agaggaaca  gatgccagc  ccctgcctg  gtcttgtgc  tgggagagt  ggatgaaac  1680
ccacagagc  gcctgtgct  cggctagta  taatgtgta  atagcactc  ggtagctgt  1740
aactgcaag  ttagcttga  ttaagggat  tggggggac  atgtaactt  attactgct  1800
gttttgaaa  gtctttgta  gagtagggt  gccatgatg  agccatatg  aagactagg  1860
tatgggtca  acttatctg  gttcctatg  aaactattt  aatatttgt  ttatatgga  1920
ttttattca  tcttcagac  cgctactca  gagtgcccc  cagctgctg  acaagcatt  1980
gtagcttgt  caatggcag  atgggccaa  agcttagtg  tgtgacctg  ttttaaaat  2040
aagtatctt  aaataatta  gc  2062



<210> 2552
<211> 461
<212> PRT
<213> Homo sapiens
<308> P11926
<400> 2552

Met Asn Asn Phe Gly Asn Glu Glu Phe Asp Cys His Phe Leu Asp Glu 
  1               5                  10                  15
Gly Phe Thr Ala Lys Asp Ile Leu Asp Gln Lys Ile Asn Glu Val Ser 
             20                  25                  30
Ser Ser Asp Asp Lys Asp Ala Phe Tyr Val Ala Asp Leu Gly Asp Ile 
         35                  40                  45
Leu Lys Lys His Leu Arg Trp Leu Lys Ala Leu Pro Arg Val Thr Pro 
     50                  55                  60
Phe Tyr Ala Val Lys Cys Asn Asp Ser Lys Ala Ile Val Lys Thr Leu 
 65                  70                  75                  80
Ala Ala Thr Gly Thr Gly Phe Asp Cys Ala Ser Lys Thr Glu Ile Gln 
                 85                  90                  95
Leu Val Gln Ser Leu Gly Val Pro Pro Glu Arg Ile Ile Tyr Ala Asn 
             100                105                110
Pro Cys Lys Gln Val Ser Gln Ile Lys Tyr Ala Ala Asn Asn Gly Val 
         115                120                125
Gln Met Met Thr Phe Asp Ser Glu Val Glu Leu Met Lys Val Ala Arg 
     130                135                140
Ala His Pro Lys Ala Lys Leu Val Leu Arg Ile Ala Thr Asp Asp Ser 
 145                150                155                160
Lys Ala Val Cys Arg Leu Ser Val Lys Phe Gly Ala Thr Leu Arg Thr 
                 165                170                175
Ser Arg Leu Leu Leu Glu Arg Ala Lys Glu Leu Asn Ile Asp Val Val 
             180                185                190
Gly Val Ser Phe His Val Gly Ser Gly Cys Thr Asp Pro Glu Thr Phe 
         195                200                205
Val Gln Ala Ile Ser Asp Ala Arg Cys Val Phe Asp Met Gly Ala Glu 
     210                215                220
Val Gly Phe Ser Met Tyr Leu Leu Asp Ile Gly Gly Gly Phe Pro Gly 
 225                230                235                240
Ser Glu Asp Val Lys Leu Lys Phe Glu Glu Ile Thr Gly Val Ile Asn 
                 245                250                255
Pro Ala Leu Asp Lys Tyr Phe Pro Ser Asp Ser Gly Val Arg Ile Ile 
             260                265                270
Ala Glu Pro Gly Arg Tyr Tyr Val Ala Ser Ala Phe Thr Leu Ala Val 
         275                280                285
Asn Ile Ile Ala Lys Lys Ile Val Leu Lys Glu Gln Thr Gly Ser Asp 
     290                295                300
Asp Glu Asp Glu Ser Ser Glu Gln Thr Phe Met Tyr Tyr Val Asn Asp 
 305                310                315                320
Gly Val Tyr Gly Ser Phe Asn Cys Ile Leu Tyr Asp His Ala His Val 
                 325                330                335
Lys Pro Leu Leu Gln Lys Arg Pro Lys Pro Asp Glu Lys Tyr Tyr Ser 
             340                345                350
Ser Ser Ile Trp Gly Pro Thr Cys Asp Gly Leu Asp Arg Ile Val Glu 
         355                360                365
Arg Cys Asp Leu Pro Glu Met His Val Gly Asp Trp Met Leu Phe Glu 
     370                375                380
Asn Met Gly Ala Tyr Thr Val Ala Ala Ala Ser Thr Phe Asn Gly Phe 
 385                390                395                400
Gln Arg Pro Thr Ile Tyr Tyr Val Met Ser Gly Pro Ala Trp Gln Leu 
                 405                410                415
Met Gln Gln Phe Gln Asn Pro Asp Phe Pro Pro Glu Val Glu Glu Gln 
             420                425                430
Asp Ala Ser Thr Leu Pro Val Ser Cys Ala Trp Glu Ser Gly Met Lys 
         435                440                445
Arg His Arg Ala Ala Cys Ala Ser Ala Ser Ile Asn Val 
     450                455                460



<210> 2553
<211> 7780
<212> DNA
<213> Rattus norvegicus
<308> J04792
<400> 2553

ggatcccgg  atccgggct  ggaaagggg  tttagttga  aattaacaa  ccattaaca  60
cgtgtacat  gtaacaagt  ggagttact  ctaagtctt  ccaatactg  atatgtaag  120
aaccagtca  tcccactta  tctttaaca  tgtaacttt  gtgggggct  gggatttag  180
tcagtggta  agcgcttac  taggaagcg  aaggccctg  gttcggtcc  cagctccaa  240
aaaaaaaaa  accaaaaaa  aaaaaacaa  aaaacaatg  aactttggt  gatacaaat  300
cactgccca  actcttttc  ggtccagac  tctcaaagt  acttagttg  agctaccct  360
aaagattta  cagaataag  gacagctgt  ggcttgaaa  ccctcaacc  cttccctaa  420
atgcgactc  tgcttagat  aaaggcatt  tcttagcat  caactggtg  ctagaatct  480
gttggaagc  accaacgta  aacggagtg  ctctccagc  tctgctggc  tgtctctca  540
caagttttc  ggcataggc  cacagggtg  tgaagcagg  tcaatctac  ccacgaagt  600
tagtctacg  ggcccgcac  caactcaag  cccatccat  ctcggctcg  acctgcgat  660
ccgccaggg  ataaatact  cgcgctgaa  gcaaagccg  ggaagagtt  tgctagtct  720
ccaggccag  gctcagccg  taggacccg  ggagagact  cgtgattga  ccggttgca  780
gacggacga  caagcgcct  tgcgcatgc  ccggccgaa  cccgcctgc  gcccatagg  840
ccctgcggc  agctggtag  caggactgg  ggtgtggtg  gcgtgcgcg  gcctgccgc  900
gggagtgtc  ggcacgagg  cgggcgggg  gcgcgggcg  atgggcggg  ggctgggca  960
gcgcggcgc  ccgccccac  gacgcgccg  gcccgcgcc  cccgcctcc  gcgtcggga  1020
ccgggttgg  cgccaagga  tccccgccc  tcccccgcg  ctcccggcc  gaaccgatc  1080
gggctggtt  gagctggtg  gtctccatg  cgacgtgct  cgcctataa  tagcggcgc  1140
tcgcaccgt  gggctttgt  agtccctgc  gccgccgcc  ccggccgcc  tcagtcagc  1200
gctcggcgc  acctccggt  ggcgactgc  gcgggctcg  cgaggcggc  gacggggcg  1260
cggcgggaa  acggccggg  gcgccttgg  gtttagtgg  ggcttctcc  tgggtccag  1320
cagccgctt  cctgtgctg  gaggtaagc  gggcgcggg  ggattgtgc  gccacgtgt  1380
gcgaggccc  gactgcggt  gccggcagg  gacacgtgg  cggaggctg  tgaccttgc  1440
agcctccgc  ctgaaggca  cagctgttc  tggcccttg  tgcaagccc  cggatcgcc  1500
catgggagc  cgcatcgtg  cagccgggc  cggcgctcc  cttgcccgg  cggtgatgg  1560
gggcaggtg  aggggagcc  ggccgctag  agccgccct  cagtttcct  ctttcttta  1620
ttttgctac  tgtacagag  agagctgat  actcgaagt  gaagtcgat  gacctaatt  1680
agtcaggga  tccctgcta  tgaatactc  ccggctgtg  cttggattt  gaactgaac  1740
ctttgaatg  cttaggggt  tacgggaaa  cggattccc  gctgtcttg  aagcccgac  1800
cagaatcct  aataactgg  agaactggg  agcagatcc  gtcaggaat  tctgggaga  1860
gacaaaaga  tgcagtggc  tgttttatt  aaacctaac  tcgggcaga  tttgactgg  1920
gttcatttt  gttttaatt  gcttgtatc  catccagat  taacttctt  tgctaattg  1980
ttaacagga  ttagctgct  cccatgcca  agtgttagc  ttttttttc  tttatcttt  2040
ttttctttt  ctttttttt  ttttttttt  ttttgtatt  aggcaaaga  agggaaagg  2100
aaaataagt  gtatttcaa  gaaagtttt  caggtttaa  ccggaaggc  gcctggaaa  2160
tacttaaca  gacctaaaa  tacaaagtt  ctgccaaag  ccattcatc  gttctaagt  2220
atatacaac  gagttggct  gcgctggtc  gtagtcttc  cttaagaga  gtttatgca  2280
ctaacgaag  tgaccagtg  caaaagtct  cttaaagct  aaagtgtgc  ttatcatgc  2340
tggatttgg  tttatgaca  gctcatccc  gtgggcctc  catagtgtc  cgtgctaga  2400
caaactggc  cctaaccat  gcccagcct  ggtgcatgt  ggctgctgg  actgaagtg  2460
gtcacacaa  ggaaaaaag  tttacctgg  cacttgctg  tggtgtcca  ttcataaga  2520
ccaggcagg  gcttttatt  agcgtggtg  tcttgctta  ttttgttag  aaaaaagtt  2580
gccaaaaat  tcttccata  ggttattat  cataagtgg  tattagaag  cacttgagg  2640
ctgttggat  cccagaagt  cgcatttgg  aggcaatcc  ggctctaga  tactgatgt  2700
tcataacag  aacaatata  tgtgaattg  attttttta  atgctagta  tgcataaaa  2760
ttagggaag  tttggtgga  tgcacacta  cattgagtg  tctggatac  tgatatact  2820
tattcacta  gtcattcag  ataactctg  aagtgggag  aaaagacct  ttcaggact  2880
catgttact  tatgcccat  aaagttttt  aagagctgg  atggctcaa  tgaagcaga  2940
aggaacatg  aataatgcc  gtaattaga  tgttaactc  gttccgttt  ggagagggg  3000
agggattga  atgttctat  tgtatagag  tgtggcatt  agttttgaa  agtgtggaa  3060
ctatttgag  tattggaga  atttggggg  ggggtcttc  cgtagttct  acctcacag  3120
tgatcttcc  gtactgtgt  ctctctggt  tactgttgc  gtgtgtaac  tttaatggt  3180
agatttcaa  ggagatagc  acatgttgt  tttctactc  ctagtgttt  caccactcc  3240
ggagacagc  ttcagagtt  accttgtga  agctggcca  aatttaatt  catctctag  3300
ttttctgtg  aagtatcag  ttatacttg  gaatttgtg  tgaagcagt  ctaagactt  3360
gagtgcatt  acttattat  tgcttattg  cagcttatt  tttcagagg  acatcgaga  3420
ccaaccatg  gcagcttta  taaggaaga  tttgactgc  atatcctcg  tgaaggttt  3480
actgctaag  acattctgg  ccaaaaaat  aatgaagtt  cttcctgtg  aagtacggg  3540
agcccacag  cacaactca  aagttccat  aaagagcat  ccttgccag  gaatctaga  3600
tttgactga  tgggctgtc  agtgagtgt  catgtcagt  ctgctaaca  ggataggat  3660
ttgttaggg  agggggaaa  agatcttca  tgtggccag  tgcaagact  ttaatgagg  3720
ccctgaacc  actcactct  attccagga  gataaggat  ctttctatg  tgcggacct  3780
ggagacgtt  taaagaagc  tctgaggtg  ctgaaagct  ttccccgtg  tactccctt  3840
tatgctgtc  agtgtaatg  cagcagagc  atagtgagc  ccctggctg  cattgggac  3900
ggatttgat  gtgcaagca  ggtaagact  cttatctca  cccaaaagg  ttatcagtt  3960
atgtgcttt  gtttgtcaa  ctccgtcta  atatactga  cttctcttt  agactgaaa  4020
acagttggt  caggggctt  gggtgcctc  agagaggat  atctatgca  atccttgta  4080
gcaagtgtc  cagatcaag  atgctgcca  taatggagt  cagatgatg  cttttgaca  4140
tgaaattga  ttgatgaaa  ttgccagag  acatccaaa  gcaaagtaa  tcttctgat  4200
gagcacaaa  aggctgggc  tgctaggca  actataatc  tggttcctt  ttcctatac  4260
tagtaagaa  caggctaaa  cctgggtta  aatcagacc  acaagcagt  gtgcctaga  4320
aggctgatt  gatgaacgt  tacagagtg  ttacttggt  catgcactt  tttctgtcc  4380
cctaggttg  ttttgcgga  tgccactga  gattccaaa  cagtttgtc  gctcagtgt  4440
aagtttggt  ccacactga  aaccagcag  cttctcttg  aacgggcaa  agagctaaa  4500
attgatgtc  ttggtgtca  gtgaggtct  agtgatagt  acagactga  acattaaat  4560
ttaaggccc  tttttcctc  gagaactag  caaagaaca  catcttgtt  ttatttcag  4620
ttccatgtg  gcagtgggt  tactgaccc  gagaccttc  tgcaggcag  gtcagatgc  4680
cgctgtgtc  ttgacatgg  agtaagtac  tgactcctg  aggagggct  tcttgattg  4740
aataaccaa  ccactgaat  tagaatttg  ctcttgtag  agctgtctg  ataacagat  4800
ttaaaacca  ctgtcctgt  catttaaac  tgtgaatct  gcaatttga  ttccaaatt  4860
tcttgattc  agacagaag  tggtttcag  atgtatctg  ttgacattg  tggtggctt  4920
cctgggtct  aagacacga  gcttaaatt  gaggaggta  ttattacaa  attaaccta  4980
agacggtga  atatgtatt  accattgtg  tgtttttac  gattaaagg  gccaacatg  5040
ctggtgttt  gttctcact  cttgttatt  gcaactgta  cccaggctg  ccttgaact  5100
tcagttctc  tgcctgttt  ccatatttt  atgtttagc  cagtgctta  cactattgt  5160
ctatgaagt  gacagggtg  aaggagtta  atcttgttg  catgtattc  gaattcagc  5220
tttggcccc  cttgtaatc  attttgtgc  attttatta  atattaata  aaactattc  5280
taatgtgtt  gaaagagat  gtcctgagg  gagtgggaa  tggtgtatg  acagactag  5340
ttccagaga  gtttgttgc  tctgttgcc  gatgacaga  ctgctatgc  aggtcatgt  5400
ctgttctta  acacagcag  gtgatcttt  tcctcaact  taacaaatg  ctgctccct  5460
ctctcactt  gatcaccag  gtaatcaac  cagctctgg  caagtactt  ccatcggac  5520
ctggagtga  aatcatagc  gagccaggc  gatactacg  cgcatcagc  ttcacactt  5580
cagtgaata  cattgccaa  aaaaccgtg  ggaaggagc  gaccggctc  gacggtatg  5640
ggtggcagg  tgagtgagt  atgtgggat  acagttgat  tgctgggtg  taattaggg  5700
gatctgttt  tctagatga  gatgagtca  acgagcaaa  tttgatgta  tacgtgaat  5760
atggagtgt  tgggtcatt  aactgcatt  tttatgacc  tgcacatgt  aaggccctg  5820
tgcagaagg  gagttctga  cgcatgctc  agcagtgag  gatgcatag  atagagaga  5880
cattgggcc  agagatggc  cagcagtta  gagcactga  tgcttccag  ggccctgag  5940
tcaatccca  caacaacat  gtggctcac  accatctgt  tgtaatgat  ccctcttct  6000
gtgtgtctg  agaatagct  cagtgtatt  ataatcttt  aaaaaaaac  aacaaaaaa  6060
aaacattgt  tttatacag  gacccaagc  agatgagaa  tattactca  ccagcatct  6120
gggaccaac  tgtgatggc  ttgatcgga  cgtcgagcg  tgtagcctg  ctgaaatgc  6180
tgtgggtga  tggatgctg  ttgagaaca  gggtgcata  actgttgct  ctgcttcta  6240
tttcaatgg  ttccagagg  caaacatct  ctacgtaat  tcacggtca  tgtggtgag  6300
ggggctgtg  ctgctcatg  tcttttggt  gctcagtgt  atgtttgcc  actgtgagc  6360
agaagcctg  gttatgcct  atgcacaca  acacacata  tatgggggg  aggcagtat  6420
tgctgaggg  aaggatcac  tgacctgtc  caaagggac  gaatttgtg  ttgcttttt  6480
tgtttgata  gtttttttt  taccttgag  taaatacag  aatggagtt  ttccaagta  6540
ttactgctc  tcttcagat  tttactact  ggagaggtc  tacaagtaa  ccattagat  6600
cttttgcaa  taaaatatt  aagttagca  atgtgacct  tgggttcct  aataatgaa  6660
ttttacatt  gattgtttc  tggtatagt  acagggtga  gtgtcagga  atctcttgg  6720
aggctgccc  atttggagg  atttgggtt  tgaatatgc  atatatgcc  ttgtttttc  6780
ggcaactca  gaagcaaat  cagagccat  gcttcccgc  agaagtgga  gagcaggat  6840
ttggcactc  gcccatgtc  tgtgcccag  agagcggga  ggaccgtca  cctgcagcc  6900
gtgcttctg  tagtatcaa  gtatagatg  cattcttgt  gctcttacc  gcaagttta  6960
cttgagttc  cggcatttg  ggggaccat  taacttaat  actgctagt  tggaatgtc  7020
ttgtaagag  agggttggc  ccaatgcag  atggaaaga  taggagatg  gggtcacac  7080
tactgtgtt  ctatggaaa  tttgaatat  ttatatgga  ttttattca  ttttcagac  7140
tgatactaa  gagtgcccc  cggctgctg  gcaagcatt  gtagcttgt  cattggcag  7200
atgggctaa  agcttatgt  gtgacccat  ttgaaaata  agtatcttg  aatgattgg  7260
cattggaga  tgtgtgcaa  tatccctta  agaaggcac  aacttctgc  caggctgtg  7320
gttacagca  tgagtctag  ccagcagag  tgtggatga  acaaagctg  gccccctct  7380
tacagcatc  atgtgctta  cccatctca  gtgtttact  tgaacttgg  gcccaaagt  7440
tcttaagag  gtcatctgc  tagtggcct  ttgacttgg  cacttccta  ggagagggc  7500
tctgaggct  tttgaacct  gcctgcaga  accctgact  ctccctcaa  ccttggcct  7560
agctgcatc  ccacctagt  acagttgaa  tatcgaaca  cacttggca  tcaacttcc  7620
gtaataaat  caacaacag  aactactgt  ttgtaaatt  ttaccttga  ctttcatat  7680
atagtcctg  tcagtttat  cacctattg  atccccaaa  aaatgccag  ctcttaacc  7740
agttagtat  gaagacctg  aggtcagga  gaagggatcc  7780



<210> 2554
<211> 461
<212> PRT
<213> Rattus norvegicus
<308> AAA66286
<400> 2554

Met Gly Ser Phe Thr Lys Glu Glu Phe Asp Cys His Ile Leu Asp Glu 
  1               5                  10                  15
Gly Phe Thr Ala Lys Asp Ile Leu Asp Gln Lys Ile Asn Glu Val Ser 
             20                  25                  30
Ser Ser Asp Asp Lys Asp Ala Phe Tyr Val Ala Asp Leu Gly Asp Val 
         35                  40                  45
Leu Lys Lys His Leu Arg Trp Leu Lys Ala Leu Pro Arg Val Thr Pro 
     50                  55                  60
Phe Tyr Ala Val Lys Cys Asn Asp Ser Arg Ala Ile Val Ser Thr Leu 
 65                  70                  75                  80
Ala Ala Ile Gly Thr Gly Phe Asp Cys Ala Ser Lys Thr Glu Ile Gln 
                 85                  90                  95
Leu Val Gln Gly Leu Gly Val Pro Pro Glu Arg Ile Ile Tyr Ala Asn 
             100                105                110
Pro Cys Lys Gln Val Ser Gln Ile Lys Tyr Ala Ala Ser Asn Gly Val 
         115                120                125
Gln Met Met Thr Phe Asp Ser Glu Ile Glu Leu Met Lys Val Ala Arg 
     130                135                140
Ala His Pro Lys Ala Lys Leu Val Leu Arg Ile Ala Thr Asp Asp Ser 
 145                150                155                160
Lys Ala Val Cys Arg Leu Ser Val Lys Phe Gly Ala Thr Leu Lys Thr 
                 165                170                175
Ser Arg Leu Leu Leu Glu Arg Ala Lys Glu Leu Asn Ile Asp Val Ile 
             180                185                190
Gly Val Ser Phe His Val Gly Ser Gly Cys Thr Asp Pro Glu Thr Phe 
         195                200                205
Val Gln Ala Val Ser Asp Ala Arg Cys Val Phe Asp Met Gly Thr Glu 
     210                215                220
Val Gly Phe Ser Met Tyr Leu Leu Asp Ile Gly Gly Gly Phe Pro Gly 
 225                230                235                240
Ser Glu Asp Thr Lys Leu Lys Phe Glu Glu Ile Thr Ser Val Ile Asn 
                 245                250                255
Pro Ala Leu Asp Lys Tyr Phe Pro Ser Asp Ser Gly Val Arg Ile Ile 
             260                265                270
Ala Glu Pro Gly Arg Tyr Tyr Val Ala Ser Ala Phe Thr Leu Ala Val 
         275                280                285
Asn Ile Ile Ala Lys Lys Thr Val Trp Lys Glu Gln Thr Gly Ser Asp 
     290                295                300
Asp Glu Asp Glu Ser Asn Glu Gln Thr Leu Met Tyr Tyr Val Asn Asp 
 305                310                315                320
Gly Val Tyr Gly Ser Phe Asn Cys Ile Leu Tyr Asp His Ala His Val 
                 325                330                335
Lys Ala Leu Leu Gln Lys Arg Pro Lys Pro Asp Glu Lys Tyr Tyr Ser 
             340                345                350
Ser Ser Ile Trp Gly Pro Thr Cys Asp Gly Leu Asp Arg Ile Val Glu 
         355                360                365
Arg Cys Ser Leu Pro Glu Met His Val Gly Asp Trp Met Leu Phe Glu 
     370                375                380
Asn Met Gly Ala Tyr Thr Val Ala Ala Ala Ser Thr Phe Asn Gly Phe 
 385                390                395                400
Gln Arg Pro Asn Ile Tyr Tyr Val Met Ser Arg Ser Met Trp Gln Leu 
                 405                410                415
Met Lys Gln Ile Gln Ser His Gly Phe Pro Pro Glu Val Glu Glu Gln 
             420                425                430
Asp Val Gly Thr Leu Pro Met Ser Cys Ala Gln Glu Ser Gly Met Asp 
         435                440                445
Arg His Pro Ala Ala Cys Ala Ser Ala Ser Ile Asn Val 
     450                455                460



<210> 2555
<211> 2062
<212> DNA
<213> Homo sapiens
<308> NM_002539
<400> 2555

gtcagtccc  cctgtagcc  ccgccgccg  cgcccgccg  ccctctgcc  gcagctccg  60
cgccacctc  ggccggcgt  tccggcggg  gggagccag  cgctgacgg  cgcggcggg  120
gcggccgag  gctcctgcg  ctgcgactc  ggctccggc  tctgcgctt  cccatgggg  180
tggcctgcg  cgcctgggc  ctctgagat  gtcactgct  ttccaaggg  acacgcaga  240
ggatttgga  ttcctggag  gttgccttt  tgagaagct  gaaatattt  tttcaattc  300
atctcttag  tttccatag  aacatcaag  aatcatgaa  aactttggt  atgaagagt  360
tgactgcca  ttcctcgat  aaggtttta  tgccaagga  attctggac  agaaaatta  420
tgaagtttc  tcttctgat  ataaggatg  cttctatgt  gcagacctg  gagacattc  480
aaagaaaca  ctgaggtgg  taaaagctc  ccctcgtgt  acccccttt  atgcagtca  540
atgtaatga  agcaaagcc  tcgtgaaga  ccttgctgc  accgggaca  gatttgact  600
tgctagcaa  actgaaata  agttggtgc  gagtctggg  gtgcctcca  agaggatta  660
ctatgcaaa  ccttgtaaa  aagtatctc  aattaagta  gctgctaat  atggagtcc  720
gatgatgac  tttgatagt  aagttgagt  gatgaaagt  gccagagca  atcccaaag  780
aaagttggt  ttgcggatt  ccactgatg  ttccaaagc  gtctgtcgt  tcagtgtga  840
attcggtgc  acgctcaga  ccagcaggc  ccttttgga  cgggcgaaa  agctaaata  900
cgatgttgt  ggtgtcagc  tccatgtag  aagcggctg  accgatcct  agaccttcg  960
gcaggcaat  tctgatgcc  gctgtgttt  tgacatggg  gctgaggtt  gtttcagca  1020
gtatctgct  gatattggc  gtggctttc  tggatctga  gatgtgaaa  ttaaatttg  1080
agagatcac  ggcgtaatc  acccagcgt  ggacaaata  tttccgtca  actctggag  1140
gagaatcat  gctgagccc  gcagatact  tgttgcatc  gctttcacg  ttgcagtta  1200
tatcattgc  aagaaaatt  tattaaagg  acagacggg  tctgatgac  aagatgagt  1260
gagtgagca  acctttatg  attatgtga  tgatggcgt  tatggatca  ttaattgca  1320
actctatga  cacgcacat  taaagcccc  tctgcaaaa  agacctaaa  cagatgaga  1380
gtattattc  tccagcata  ggggaccaa  atgtgatgg  ctcgatcgg  ttgttgagc  1440
ctgtgacct  cctgaaatg  atgtgggtg  ttggatgct  tttgaaaac  tgggcgctt  1500
cactgttgc  gctgcctct  cgttcaatg  cttccagag  ccgacgatc  actatgtga  1560
gtcagggcc  gcgtggcaa  tcatgcagc  attccagaa  cccgacttc  cacccgaag  1620
agaggaaca  gatgccagc  ccctgcctg  gtcttgtgc  tgggagagt  ggatgaaac  1680
ccacagagc  gcctgtgct  cggctagta  taatgtgta  atagcactc  ggtagctgt  1740
aactgcaag  ttagcttga  ttaagggat  tggggggac  atgtaactt  attactgct  1800
gttttgaaa  gtctttgta  gagtagggt  gccatgatg  agccatatg  aagactagg  1860
tatgggtca  acttatctg  gttcctatg  aaactattt  aatatttgt  ttatatgga  1920
ttttattca  tcttcagac  cgctactca  gagtgcccc  cagctgctg  acaagcatt  1980
gtagcttgt  caatggcag  atgggccaa  agcttagtg  tgtgacctg  ttttaaaat  2040
aagtatctt  aaataatta  gc  2062



<210> 2556
<211> 461
<212> PRT
<213> Homo sapiens
<308> P11926
<400> 2556

Met Asn Asn Phe Gly Asn Glu Glu Phe Asp Cys His Phe Leu Asp Glu 
  1               5                  10                  15
Gly Phe Thr Ala Lys Asp Ile Leu Asp Gln Lys Ile Asn Glu Val Ser 
             20                  25                  30
Ser Ser Asp Asp Lys Asp Ala Phe Tyr Val Ala Asp Leu Gly Asp Ile 
         35                  40                  45
Leu Lys Lys His Leu Arg Trp Leu Lys Ala Leu Pro Arg Val Thr Pro 
     50                  55                  60
Phe Tyr Ala Val Lys Cys Asn Asp Ser Lys Ala Ile Val Lys Thr Leu 
 65                  70                  75                  80
Ala Ala Thr Gly Thr Gly Phe Asp Cys Ala Ser Lys Thr Glu Ile Gln 
                 85                  90                  95
Leu Val Gln Ser Leu Gly Val Pro Pro Glu Arg Ile Ile Tyr Ala Asn 
             100                105                110
Pro Cys Lys Gln Val Ser Gln Ile Lys Tyr Ala Ala Asn Asn Gly Val 
         115                120                125
Gln Met Met Thr Phe Asp Ser Glu Val Glu Leu Met Lys Val Ala Arg 
     130                135                140
Ala His Pro Lys Ala Lys Leu Val Leu Arg Ile Ala Thr Asp Asp Ser 
 145                150                155                160
Lys Ala Val Cys Arg Leu Ser Val Lys Phe Gly Ala Thr Leu Arg Thr 
                 165                170                175
Ser Arg Leu Leu Leu Glu Arg Ala Lys Glu Leu Asn Ile Asp Val Val 
             180                185                190
Gly Val Ser Phe His Val Gly Ser Gly Cys Thr Asp Pro Glu Thr Phe 
         195                200                205
Val Gln Ala Ile Ser Asp Ala Arg Cys Val Phe Asp Met Gly Ala Glu 
     210                215                220
Val Gly Phe Ser Met Tyr Leu Leu Asp Ile Gly Gly Gly Phe Pro Gly 
 225                230                235                240
Ser Glu Asp Val Lys Leu Lys Phe Glu Glu Ile Thr Gly Val Ile Asn 
                 245                250                255
Pro Ala Leu Asp Lys Tyr Phe Pro Ser Asp Ser Gly Val Arg Ile Ile 
             260                265                270
Ala Glu Pro Gly Arg Tyr Tyr Val Ala Ser Ala Phe Thr Leu Ala Val 
         275                280                285
Asn Ile Ile Ala Lys Lys Ile Val Leu Lys Glu Gln Thr Gly Ser Asp 
     290                295                300
Asp Glu Asp Glu Ser Ser Glu Gln Thr Phe Met Tyr Tyr Val Asn Asp 
 305                310                315                320
Gly Val Tyr Gly Ser Phe Asn Cys Ile Leu Tyr Asp His Ala His Val 
                 325                330                335
Lys Pro Leu Leu Gln Lys Arg Pro Lys Pro Asp Glu Lys Tyr Tyr Ser 
             340                345                350
Ser Ser Ile Trp Gly Pro Thr Cys Asp Gly Leu Asp Arg Ile Val Glu 
         355                360                365
Arg Cys Asp Leu Pro Glu Met His Val Gly Asp Trp Met Leu Phe Glu 
     370                375                380
Asn Met Gly Ala Tyr Thr Val Ala Ala Ala Ser Thr Phe Asn Gly Phe 
 385                390                395                400
Gln Arg Pro Thr Ile Tyr Tyr Val Met Ser Gly Pro Ala Trp Gln Leu 
                 405                410                415
Met Gln Gln Phe Gln Asn Pro Asp Phe Pro Pro Glu Val Glu Glu Gln 
             420                425                430
Asp Ala Ser Thr Leu Pro Val Ser Cys Ala Trp Glu Ser Gly Met Lys 
         435                440                445
Arg His Arg Ala Ala Cys Ala Ser Ala Ser Ile Asn Val 
     450                455                460



<210> 2557
<211> 4487
<212> DNA
<213> Rattus norvegicus
<308> J04793
<400> 2557

agcgggtgg  gagaagaga  gagatacag  agggaaagg  gggatgcta  aatggtttc  60
aacactgtg  cttggggct  tctctcctc  tctcagagg  ggggtctgg  tgggggctc  120
gatcaccac  ataaattcc  ggttcacca  taaaattca  gtggagagt  gcagcagac  180
catgttagg  ccagaatag  cacggctgt  gaactggga  gaggtccca  cccagggga  240
gtggaagga  tgggtctgg  ttcctgagg  tccctgaaa  tagtacggt  gggcctgag  300
agagggcca  atcccaggt  atactaatt  gctcttggg  tttcagctc  tcccacaga  360
caaacagcc  cagactaca  ccccaccag  acctccaca  cgcacccaa  ctccagtca  420
gtctatgta  agctgcagg  actgatgat  gaccagagg  accaggaac  acagtgggt  480
gaggcggca  actggatag  gctggagga  aaccttcga  aggatggtg  gtggggtcg  540
ccacatctc  cttacctca  cttctggag  cttctagaa  tgcagaagg  cttctcaaa  600
ggcaccttc  ttctggatc  ggcagagac  tccctggct  gggtggcca  taaacttct  660
gacagtttc  tctatgagg  tcaaattcg  cctcaagac  gagatgagc  gctccgggc  720
ctgctactc  aacgcagcc  cgctgagga  ctaaaggat  tggagggag  gaagcctgc  780
gtcctgacc  gctctgggg  cccttctga  cctcttctt  ctcaccagc  atcgctgga  840
accaagctg  actgtgcac  ggcagaggg  ggctcagaa  aaccctcgc  atctgggat  900
ctgaagatc  cccccaatt  agaaaccac  ttggtgcta  tgggccggg  tagtttcct  960
gtgaagcct  tgctgggct  cgtgagact  aaggaagct  tgccgctgg  ggacctggt  1020
ttgccggag  ctgtgagct  ccttctagt  cttctcgga  ctgaggctc  gcacatcga  1080
tacacccag  tgggcaggg  tgcagcaac  ctcatgaca  aaagagtgt  ccgcgttac  1140
gcctccctg  cgcagagcc  aggggagct  ctgagctcc  tggatagct  tctggactg  1200
agcctggtg  tgccgccca  agaggcccc  tcagagaaa  ctctgctca  cctggtgcc  1260
gtgcagaag  agttgctta  gaagcggta  ttgcccaga  ctgccaagc  agaccccaa  1320
ttgtacgag  cattagacg  gggaaagga  ggccccggt  acgaagacg  ccctctaag  1380
cgcaccggc  ggatctttg  aggcctgat  cgtgatatc  ggcgccggt  tccttacta  1440
ctgagtgac  tcaccgatg  gctcagtcc  caggtgctg  ctgctgtca  cttcatcta  1500
tttgctgcc  tgtcacctg  ggtcacctt  ggcggtctc  tgggagaaa  gacccggaa  1560
ctgatgggg  tgtcagagc  gctcatctc  acagcagtg  aaggaattc  ctttgctct  1620
ctgggggca  agcccctgc  tgtgctcgg  ttctcagga  ccctgctgg  gtttgaaga  1680
gccttctac  cgttctgtg  aagcaataa  ctggagtac  tcgtgggcc  cgcgtggat  1740
ggcttctgg  ttatcctgc  ggtggtgtt  gtggtggcc  ttgaaggca  cttcctggt  1800
caatacatc  cccgctaca  tcaggagat  ttctccttc  tcatctccc  catcttcat  1860
tatgagact  tctctaagc  gatcaagat  ttccaggac  acccgctac  agagagcta  1920
gcccctgtt  tgatgaagc  caaacctca  ggccccgtg  ccaacacag  cctcctctc  1980
cttgtgctt  tggttggta  cttcctact  gccatgatg  tacgaaagt  caagaacag  2040
acctacttc  ccggcaagc  acgcagagt  attggggac  ttggggtcc  catctccat  2100
ctgataatg  tcctggtgg  taccttcat  aagaacacc  acacgcaga  actctcggt  2160
cctgatggc  ttaaagtgt  caactcctc  gcccggggc  gggtcatcc  tcccctggg  2220
ctgtataac  atttcccca  gtggatgat  tttgcttct  ttctacccg  tctgcttgt  2280
ttcatcctt  tattccttg  gtctcagat  accacgctg  ttgtcagta  acctgagcg  2340
aagatgatc  agggctccg  cttccacct  gacttgctg  tggttgttg  catgggcgg  2400
gtggccgcc  tctttggga  gccttggct  agcgccacc  ctgtgcgtt  tgttaccca  2460
gccaacgcc  tcacagtca  ggggaaggc  agtggtcca  gggctgcag  ccagatcca  2520
gaggtcaag  aacagcgga  cagtgggct  ctggtctct  tgctcgtgg  actgtccat  2580
ctcatggaa  ccatcctgt  ccgcatccc  ctggctgta  tgtttggca  cttcctgta  2640
atggggatc  catccctca  tggcatcca  ctctttgac  gcatcttgc  cctgttcaa  2700
ccacccaag  accacccag  tgtgccctt  gtcaagagg  tgaagacct  gcgtatgca  2760
ctcttcacg  gcatccaga  catctgcct  gctgtgctg  gggtggtga  gtccacgcc  2820
gcctcgctg  ccctgccct  tgtcctcat  ctcaccgtg  ccctgcgtc  tctcctcct  2880
ccgctcatc  tcagagagc  agaactcca  tgtctggat  gtgatgatg  caaagtgac  2940
tttgacgag  cggaagggc  ggatgagta  gacgaagtg  ccatgcctg  gtgaggggc  3000
ggcccaggc  cccaaccac  ccactttcc  accctcctg  gaagaccat  catgggcat  3060
tcatggctg  gggtgggga  ggagaggtt  tctaggaaa  tctctacat  aggtatacg  3120
gattttctg  ctggagacg  ccagaagtt  tatcaggga  ttggggtca  agtctcttg  3180
gactgtacg  gtcccatgt  gcatagtta  aaatagcaa  ggggagaca  ttttcaagt  3240
cctgctggc  gtgtggcct  aagtaagtc  cttgacctc  ctggcctct  ccccctact  3300
tatagaatg  atgcattgg  aataatacc  atgttaccg  ctgctgagg  ccaagagca  3360
atgtctaag  actattaca  tcttcattg  tctcagagc  tgcccagat  acacagccc  3420
ctccccccc  cccggggcc  cacagcagg  acctgagcc  cctgacctg  aggctacag  3480
tctgtcctc  gtcttccca  tcatgccca  aaatacccc  aatgtcttc  attttctgt  3540
ccaccccca  cccaagtct  ccttctctg  atctagaga  atattctga  gagagtaag  3600
tacaggtga  ggactgagg  tcgtattcc  aagtacttg  tctctctca  caggtgttc  3660
ttcattcat  cattcattc  ttcattcat  cattccata  ccatctact  aaggcccta  3720
acctagtgg  cacagaggg  ctggttcaa  cttcttttg  ggggtgagg  caatacata  3780
gtctgctct  gacatggat  gggatagcg  gaggatggg  gggttgtaa  ttattaact  3840
tgtattttc  gagtgcttc  tccgtgcct  ggttttgcc  acacactca  ccctcatga  3900
agacttgct  tgtccaacc  cagctaaac  gagtcttgg  ggagcgaaa  ccaagtttt  3960
acccattgg  gtaggagac  gtagcttgt  caaaatatg  ataaacaac  atttttatt  4020
ttgacaaag  aatatattt  ttaaaaaaa  aaaaaagtt  aaagaacca  aacttgaga  4080
aagaaacag  agatctgag  gatcaggca  cagggggct  ccagtggaa  atgctgggg  4140
ggggggatt  gagagccca  gtttgcctc  caggactgc  tcaccacag  ctcttgttc  4200
ctcatcata  aaataggga  aaggatgca  ctaccttgt  gggagttgg  aggattgac  4260
gacaccgta  aagaaaagc  tttgcagag  acacagcct  ccttgtggg  agttgctga  4320
gtgaccacg  cgctgggca  acccctatc  tctcctgcc  ttcctactc  ttgaacatt  4380
ccaaagaga  tggggatcc  gctgcccac  ctccagcgc  cttccccac  gccgtgctt  4440
ggaataggt  ttgccaata  atgtgtctg  gttaaaaaa  aaaaaaa  4487



<210> 2558
<211> 927
<212> PRT
<213> Rattus norvegicus
<308> AAA40800
<400> 2558

Met Gly Asp Met Gln Asp His Glu Lys Val Leu Glu Ile Pro Asp Arg 
  1               5                  10                  15
Asp Ser Glu Glu Glu Leu Glu His Val Ile Glu Gln Ile Ala Tyr Arg 
             20                  25                  30
Asp Leu Asp Ile Pro Val Thr Glu Met Gln Glu Ser Glu Ala Leu Pro 
         35                  40                  45
Thr Glu Gln Thr Ala Thr Asp Tyr Ile Pro Thr Ser Thr Ser Thr Ser 
     50                  55                  60
His Pro Ser Ser Ser Gln Val Tyr Val Glu Leu Gln Glu Leu Met Met 
 65                  70                  75                  80
Asp Gln Arg Asn Gln Glu Leu Gln Trp Val Glu Ala Ala His Trp Ile 
                 85                  90                  95
Gly Leu Glu Glu Asn Leu Arg Glu Asp Gly Val Trp Gly Arg Pro His 
             100                105                110
Leu Ser Tyr Leu Thr Phe Trp Ser Leu Leu Glu Leu Gln Lys Val Phe 
         115                120                125
Ser Lys Gly Thr Phe Leu Leu Asp Leu Ala Glu Thr Ser Leu Ala Gly 
     130                135                140
Val Ala Asn Lys Leu Leu Asp Ser Phe Ile Tyr Glu Asp Gln Ile Arg 
 145                150                155                160
Pro Gln Asp Arg Asp Glu Leu Leu Arg Ala Leu Leu Leu Lys Arg Ser 
                 165                170                175
His Ala Glu Asp Leu Lys Asp Leu Glu Gly Val Lys Pro Ala Val Leu 
             180                185                190
Thr Arg Ser Gly Ala Pro Ser Glu Pro Leu Leu Pro His Gln Pro Ser 
         195                200                205
Leu Glu Thr Lys Leu Tyr Cys Ala Gln Ala Glu Gly Gly Ser Glu Glu 
     210                215                220
Pro Ser Pro Ser Gly Ile Leu Lys Ile Pro Pro Asn Ser Glu Thr Thr 
 225                230                235                240
Leu Val Leu Val Gly Arg Ala Ser Phe Leu Val Lys Pro Val Leu Gly 
                 245                250                255
Phe Val Arg Leu Lys Glu Ala Val Pro Leu Glu Asp Leu Val Leu Pro 
             260                265                270
Glu Pro Val Ser Phe Leu Leu Val Leu Leu Gly Pro Glu Ala Pro His 
         275                280                285
Ile Asp Tyr Thr Gln Leu Gly Arg Ala Ala Ala Thr Leu Met Thr Glu 
     290                295                300
Arg Val Phe Arg Val Thr Ala Ser Leu Ala Gln Ser Arg Gly Glu Leu 
 305                310                315                320
Leu Ser Ser Leu Asp Ser Phe Leu Asp Cys Ser Leu Val Leu Pro Pro 
                 325                330                335
Thr Glu Ala Pro Ser Glu Lys Ala Leu Leu Asn Leu Val Pro Val Gln 
             340                345                350
Lys Glu Leu Leu Arg Lys Arg Tyr Leu Pro Arg Pro Ala Lys Pro Asp 
         355                360                365
Pro Asn Leu Tyr Glu Ala Leu Asp Gly Gly Lys Glu Gly Pro Gly Asp 
     370                375                380
Glu Asp Asp Pro Leu Arg Arg Thr Gly Arg Ile Phe Gly Gly Leu Ile 
 385                390                395                400
Arg Asp Ile Arg Arg Arg Tyr Pro Tyr Tyr Leu Ser Asp Ile Thr Asp 
                 405                410                415
Ala Leu Ser Pro Gln Val Leu Ala Ala Val Ile Phe Ile Tyr Phe Ala 
             420                425                430
Ala Leu Ser Pro Ala Val Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr 
         435                440                445
Arg Asn Leu Met Gly Val Ser Glu Leu Leu Ile Ser Thr Ala Val Gln 
     450                455                460
Gly Ile Leu Phe Ala Leu Leu Gly Ala Gln Pro Leu Leu Val Leu Gly 
 465                470                475                480
Phe Ser Gly Pro Leu Leu Val Phe Glu Glu Ala Phe Tyr Ser Phe Cys 
                 485                490                495
Glu Ser Asn Asn Leu Glu Tyr Ile Val Gly Arg Ala Trp Ile Gly Phe 
             500                505                510
Trp Leu Ile Leu Leu Val Val Leu Val Val Ala Phe Glu Gly Ser Phe 
         515                520                525
Leu Val Gln Tyr Ile Ser Arg Tyr Thr Gln Glu Ile Phe Ser Phe Leu 
     530                535                540
Ile Ser Leu Ile Phe Ile Tyr Glu Thr Phe Ser Lys Leu Ile Lys Ile 
 545                550                555                560
Phe Gln Asp Tyr Pro Leu Gln Glu Ser Tyr Ala Pro Val Val Met Lys 
                 565                570                575
Pro Lys Pro Gln Gly Pro Val Pro Asn Thr Ala Leu Leu Ser Leu Val 
             580                585                590
Leu Met Val Gly Thr Phe Leu Leu Ala Met Met Leu Arg Lys Phe Lys 
         595                600                605
Asn Ser Thr Tyr Phe Pro Gly Lys Leu Arg Arg Val Ile Gly Asp Phe 
     610                615                620
Gly Val Pro Ile Ser Ile Leu Ile Met Val Leu Val Asp Thr Phe Ile 
 625                630                635                640
Lys Asn Thr Tyr Thr Gln Lys Leu Ser Val Pro Asp Gly Leu Lys Val 
                 645                650                655
Ser Asn Ser Ser Ala Arg Gly Trp Val Ile His Pro Leu Gly Leu Tyr 
             660                665                670
Asn His Phe Pro Lys Trp Met Met Phe Ala Ser Val Leu Pro Ala Leu 
         675                680                685
Leu Val Phe Ile Leu Ile Phe Leu Glu Ser Gln Ile Thr Thr Leu Ile 
     690                695                700
Val Ser Lys Pro Glu Arg Lys Met Ile Lys Gly Ser Gly Phe His Leu 
 705                710                715                720
Asp Leu Leu Leu Val Val Gly Met Gly Gly Val Ala Ala Leu Phe Gly 
                 725                730                735
Met Pro Trp Leu Ser Ala Thr Thr Val Arg Ser Val Thr His Ala Asn 
             740                745                750
Ala Leu Thr Val Met Gly Lys Ala Ser Gly Pro Gly Ala Ala Ala Gln 
         755                760                765
Ile Gln Glu Val Lys Glu Gln Arg Ile Ser Gly Leu Leu Val Ser Val 
     770                775                780
Leu Val Gly Leu Ser Ile Leu Met Glu Pro Ile Leu Ser Arg Ile Pro 
 785                790                795                800
Leu Ala Val Leu Phe Gly Ile Phe Leu Tyr Met Gly Ile Thr Ser Leu 
                 805                810                815
Ser Gly Ile Gln Leu Phe Asp Arg Ile Leu Leu Leu Phe Lys Pro Pro 
             820                825                830
Lys Tyr His Pro Asp Val Pro Phe Val Lys Arg Val Lys Thr Trp Arg 
         835                840                845
Met His Leu Phe Thr Gly Ile Gln Ile Ile Cys Leu Ala Val Leu Trp 
     850                855                860
Val Val Lys Ser Thr Pro Ala Ser Leu Ala Leu Pro Phe Val Leu Ile 
 865                870                875                880
Leu Thr Val Pro Leu Arg Arg Leu Leu Leu Pro Leu Ile Phe Arg Glu 
                 885                890                895
Leu Glu Leu Gln Cys Leu Asp Gly Asp Asp Ala Lys Val Thr Phe Asp 
             900                905                910
Glu Ala Glu Gly Leu Asp Glu Tyr Asp Glu Val Pro Met Pro Val 
         915                920                925



<210> 2559
<211> 3637
<212> DNA
<213> Homo sapiens
<308> NM_000342
<400> 2559

cagcggctg  aggacttca  caagggacc  tgaggctcg  gagcaggga  ccgcggtgc  60
ggttatgct  ggggctcag  tcaccgtag  caactggac  ctcaggacc  cgccatgga  120
gagctgcag  atgattatg  agacatgat  gaggagaat  tggagcagg  ggaatatga  180
gacccagac  tccccgagt  ccagatgga  gagccggca  ctcacgaca  cgaggcaac  240
gccacagac  accacacca  atcacaccc  ggtacccac  aggtctatg  ggagctgca  300
gagctggtg  tggacgaaa  gaaccagga  ctgagatgg  tggaggcgg  gcgctgggt  360
caactggag  agaacctgg  ggagaatgg  gcctggggc  gcccgcacc  ctctcacct  420
accttctgg  gcctcctag  gctgcgtag  gtcttcacc  agggtactg  tctcctaga  480
ctgcaagag  cctccctgg  tggagtggc  aaccaactg  tagacaggt  tatctttga  540
gaccagatc  ggcctcagg  ccgagagga  ctgctccgg  ccctgctgc  taaacacag  600
cacgctgga  agctggagg  cctgggggg  gtgaagcct  cagtcctga  acgctctgg  660
gatccttca  agcctctgc  cccccaaca  tcctcactg  agacacagc  cttctgtga  720
cagggagat  ggggcacag  agggcactc  ccatctgga  ttctggaaa  gattccccc  780
gattcagag  ccacgttgg  gctagtggg  cgcgccgac  tcctggagc  gccggtgct  840
ggcttcgtg  ggctgcagg  ggcagcgga  ctggaggcg  tggagctgc  ggtgcctat  900
cgcttcctc  ttgtgttgc  gggacctga  gccccccac  tcgattaca  ccagcttgg  960
cgggctgct  ccaccctca  gtcagagag  gtgttccgc  tagatgcct  catggctca  1020
agccgaggg  agctgctgc  ctccctaga  ggcttcctg  actgcagcc  agtgctgcc  1080
cccaccgat  ccccctccg  gcaggcact  ctcagtctg  tgcctgtgc  gagggagct  1140
cttcgaagg  gctatcagt  cagccctgc  aagccagac  ccagcttct  caagggcct  1200
gacttaaat  ggggcccag  tgaccctct  cagcagaca  gccagctct  cgggggcct  1260
gtgcgtgat  tccggcgcc  ctaccccta  tacctgagt  acatcacag  tgcattcag  1320
ccccaggtc  tggctgccg  catcttcat  tactttgct  cactgtcac  cgccatcac  1380
ttcggcggc  tcctgggag  aaagacccg  aaccagatg  gagtgtcgg  gctgctgat  1440
tccactgca  tgcagggca  tctcttcgc  ctgctgggg  ctcagcccc  gcttgtggt  1500
ggcttctca  gacccctgc  ggtgtttga  gaagccttc  tctcgttct  cgagaccaa  1560
ggtctagag  acatcgtgg  ccgcgtgtg  atcggcttc  ggctcatcc  gctggtggt  1620
ttggtggtg  ccttcgagg  tagcttcct  gtccgcttc  tctcccgct  tacccagga  1680
atcttctcc  tcctcattt  cctcatctt  atctatgag  ctttctcca  gctgatcaa  1740
atcttccag  accacccac  acagaagac  tataactac  acgtgttga  ggtgcccaa  1800
cctcagggc  ccctgccca  cacagccct  ctctccctt  tgctcatgg  cggtacctt  1860
ttctttgcc  tgatgctgc  caagttcaa  aacagctcc  atttccctg  caagctgcg  1920
cgggtcatc  gggacttcg  ggtccccat  tccatcctg  tcatggtcc  ggtggattt  1980
ttcattcag  atacctaca  ccagaaact  tcggtgcct  atggcttca  ggtgtccaa  2040
tcctcagcc  ggggctggg  catccaccc  ctgggcttg  gttccgagt  tcccatctg  2100
atgatgttt  cctccgccc  gcctgctct  ctggtcttc  tcctcatat  cctggagtc  2160
cagatcacc  cgctgattg  cagcaaacc  gagcgcaag  tggtcaagg  ctccggctt  2220
cacctggac  tgctgctgg  agtaggcat  ggtggggtg  ccgccctct  tgggatgcc  2280
tggctcagt  ccaccaccg  gcgttccgt  acccatgcc  acgccctca  tgtcatggg  2340
aaagccagc  ccccagggg  tgcagccca  atccaggag  tcaaagagc  gcggatcag  2400
ggactcctg  tcgctgtgc  tgtgggcct  tccatcctc  tggagccca  cctgtcccg  2460
atccccctg  ctgtactgt  tggcatctt  ctctacatg  gggtcacgt  gctcagcgg  2520
atccagctc  ttgaccgca  cttgcttct  ttcaagcca  ccaagtatc  cccagatgt  2580
ccctacgtc  agcgggtga  gacctggcg  atgcactta  tcacgggca  ccagatcat  2640
tgcctggca  tgctgtggg  ggtgaagtc  acgccggcc  ccctggccc  gcccttcgt  2700
ctcatcctc  ctgtgccgc  gcggcgcgt  ctgctgccg  tcatcttca  gaacgtgga  2760
cttcagtgt  tggatgctg  tgatgccaa  gcaaccttt  atgaggagg  aggtcggga  2820
gaatacgac  aagtggcca  gcctgtgtg  ggggcgggc  caggcccta  accctcccc  2880
accattcca  atccccacc  tccaaggaa  agcagaagt  catgggcac  tcatggact  2940
aggatcctc  tggagcagc  gctgaggcc  cagggctgt  ggtggggaa  gaaggcgtg  3000
ccaggagac  ttccacaaa  ggtagcctg  cttttctgg  tggggatgg  cgatggggc  3060
cacattagg  ggtttgttg  acagtccct  ctgttgcca  actttcact  gggatcccg  3120
gctggaaga  ttagatctg  gccctccct  ttcccagca  aggcagggg  agaagcaaa  3180
gcaggaggt  ggtgagcgg  tggggtgct  gctgtgtga  cttgggtaa  tcccttgac  3240
tttccaggc  tatatttcc  cttctgtaa  atgggtata  tgatgataa  acccacatt  3300
caggatggt  actgaggac  aaagataca  gtaaaatag  gctttgtaa  ctccacagg  3360
actgttcta  agcagtcat  atttgtctt  gaacgtacc  aaggtcaca  agctgggat  3420
tgaactgag  cgtgcagct  ggatttgaa  caggccttc  gatttcaag  tccgagctc  3480
gtcctctgt  agtcatgcg  ccactttcc  ttcccctgt  actcctccc  tccccactc  3540
gctcccagc  cctaccttg  gaccctctt  tctgggccc  gagagaggc  tcctgggtg  3600
aggaaggta  aggcaggat  atccaggga  tgggctg  3637



<210> 2560
<211> 911
<212> PRT
<213> Homo sapiens
<308> P02730
<400> 2560

Met Glu Glu Leu Gln Asp Asp Tyr Glu Asp Met Met Glu Glu Asn Leu 
  1               5                  10                  15
Glu Gln Glu Glu Tyr Glu Asp Pro Asp Ile Pro Glu Ser Gln Met Glu 
             20                  25                  30
Glu Pro Ala Ala His Asp Thr Glu Ala Thr Ala Thr Asp Tyr His Thr 
         35                  40                  45
Thr Ser His Pro Gly Thr His Lys Val Tyr Val Glu Leu Gln Glu Leu 
     50                  55                  60
Val Met Asp Glu Lys Asn Gln Glu Leu Arg Trp Met Glu Ala Ala Arg 
 65                  70                  75                  80
Trp Val Gln Leu Glu Glu Asn Leu Gly Glu Asn Gly Ala Trp Gly Arg 
                 85                  90                  95
Pro His Leu Ser His Leu Thr Phe Trp Ser Leu Leu Glu Leu Arg Arg 
             100                105                110
Val Phe Thr Lys Gly Thr Val Leu Leu Asp Leu Gln Glu Thr Ser Leu 
         115                120                125
Ala Gly Val Ala Asn Gln Leu Leu Asp Arg Phe Ile Phe Glu Asp Gln 
     130                135                140
Ile Arg Pro Gln Asp Arg Glu Glu Leu Leu Arg Ala Leu Leu Leu Lys 
 145                150                155                160
His Ser His Ala Gly Glu Leu Glu Ala Leu Gly Gly Val Lys Pro Ala 
                 165                170                175
Val Leu Thr Arg Ser Gly Asp Pro Ser Gln Pro Leu Leu Pro Gln His 
             180                185                190
Ser Ser Leu Glu Thr Gln Leu Phe Cys Glu Gln Gly Asp Gly Gly Thr 
         195                200                205
Glu Gly His Ser Pro Ser Gly Ile Leu Glu Lys Ile Pro Pro Asp Ser 
     210                215                220
Glu Ala Thr Leu Val Leu Val Gly Arg Ala Asp Phe Leu Glu Gln Pro 
 225                230                235                240
Val Leu Gly Phe Val Arg Leu Gln Glu Ala Ala Glu Leu Glu Ala Val 
                 245                250                255
Glu Leu Pro Val Pro Ile Arg Phe Leu Phe Val Leu Leu Gly Pro Glu 
             260                265                270
Ala Pro His Ile Asp Tyr Thr Gln Leu Gly Arg Ala Ala Ala Thr Leu 
         275                280                285
Met Ser Glu Arg Val Phe Arg Ile Asp Ala Tyr Met Ala Gln Ser Arg 
     290                295                300
Gly Glu Leu Leu His Ser Leu Glu Gly Phe Leu Asp Cys Ser Leu Val 
 305                310                315                320
Leu Pro Pro Thr Asp Ala Pro Ser Glu Gln Ala Leu Leu Ser Leu Val 
                 325                330                335
Pro Val Gln Arg Glu Leu Leu Arg Arg Arg Tyr Gln Ser Ser Pro Ala 
             340                345                350
Lys Pro Asp Ser Ser Phe Tyr Lys Gly Leu Asp Leu Asn Gly Gly Pro 
         355                360                365
Asp Asp Pro Leu Gln Gln Thr Gly Gln Leu Phe Gly Gly Leu Val Arg 
     370                375                380
Asp Ile Arg Arg Arg Tyr Pro Tyr Tyr Leu Ser Asp Ile Thr Asp Ala 
 385                390                395                400
Phe Ser Pro Gln Val Leu Ala Ala Val Ile Phe Ile Tyr Phe Ala Ala 
                 405                410                415
Leu Ser Pro Ala Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Arg 
             420                425                430
Asn Gln Met Gly Val Ser Glu Leu Leu Ile Ser Thr Ala Val Gln Gly 
         435                440                445
Ile Leu Phe Ala Leu Leu Gly Ala Gln Pro Leu Leu Val Val Gly Phe 
     450                455                460
Ser Gly Pro Leu Leu Val Phe Glu Glu Ala Phe Phe Ser Phe Cys Glu 
 465                470                475                480
Thr Asn Gly Leu Glu Tyr Ile Val Gly Arg Val Trp Ile Gly Phe Trp 
                 485                490                495
Leu Ile Leu Leu Val Val Leu Val Val Ala Phe Glu Gly Ser Phe Leu 
             500                505                510
Val Arg Phe Ile Ser Arg Tyr Thr Gln Glu Ile Phe Ser Phe Leu Ile 
         515                520                525
Ser Leu Ile Phe Ile Tyr Glu Thr Phe Ser Lys Leu Ile Lys Ile Phe 
     530                535                540
Gln Asp His Pro Leu Gln Lys Thr Tyr Asn Tyr Asn Val Leu Met Val 
 545                550                555                560
Pro Lys Pro Gln Gly Pro Leu Pro Asn Thr Ala Leu Leu Ser Leu Val 
                 565                570                575
Leu Met Ala Gly Thr Phe Phe Phe Ala Met Met Leu Arg Lys Phe Lys 
             580                585                590
Asn Ser Ser Tyr Phe Pro Gly Lys Leu Arg Arg Val Ile Gly Asp Phe 
         595                600                605
Gly Val Pro Ile Ser Ile Leu Ile Met Val Leu Val Asp Phe Phe Ile 
     610                615                620
Gln Asp Thr Tyr Thr Gln Lys Leu Ser Val Pro Asp Gly Phe Lys Val 
 625                630                635                640
Ser Asn Ser Ser Ala Arg Gly Trp Val Ile His Pro Leu Gly Leu Arg 
                 645                650                655
Ser Glu Phe Pro Ile Trp Met Met Phe Ala Ser Ala Leu Pro Ala Leu 
             660                665                670
Leu Val Phe Ile Leu Ile Phe Leu Glu Ser Gln Ile Thr Thr Leu Ile 
         675                680                685
Val Ser Lys Pro Glu Arg Lys Met Val Lys Gly Ser Gly Phe His Leu 
     690                695                700
Asp Leu Leu Leu Val Val Gly Met Gly Gly Val Ala Ala Leu Phe Gly 
 705                710                715                720
Met Pro Trp Leu Ser Ala Thr Thr Val Arg Ser Val Thr His Ala Asn 
                 725                730                735
Ala Leu Thr Val Met Gly Lys Ala Ser Thr Pro Gly Ala Ala Ala Gln 
             740                745                750
Ile Gln Glu Val Lys Glu Gln Arg Ile Ser Gly Leu Leu Val Ala Val 
         755                760                765
Leu Val Gly Leu Ser Ile Leu Met Glu Pro Ile Leu Ser Arg Ile Pro 
     770                775                780
Leu Ala Val Leu Phe Gly Ile Phe Leu Tyr Met Gly Val Thr Ser Leu 
 785                790                795                800
Ser Gly Ile Gln Leu Phe Asp Arg Ile Leu Leu Leu Phe Lys Pro Pro 
                 805                810                815
Lys Tyr His Pro Asp Val Pro Tyr Val Lys Arg Val Lys Thr Trp Arg 
             820                825                830
Met His Leu Phe Thr Gly Ile Gln Ile Ile Cys Leu Ala Val Leu Trp 
         835                840                845
Val Val Lys Ser Thr Pro Ala Ser Leu Ala Leu Pro Phe Val Leu Ile 
     850                855                860
Leu Thr Val Pro Leu Arg Arg Val Leu Leu Pro Leu Ile Phe Arg Asn 
 865                870                875                880
Val Glu Leu Gln Cys Leu Asp Ala Asp Asp Ala Lys Ala Thr Phe Asp 
                 885                890                895
Glu Glu Glu Gly Arg Asp Glu Tyr Asp Glu Val Ala Met Pro Val 
             900                905                910



<210> 2561
<211> 431
<212> DNA
<213> Rattus norvegicus
<308> J04807
<400> 2561

agcctaagt  accagctac  gtcggaaac  atcagcaag  aggtcattg  ccctgtgga  60
ccgcttcct  cccctgctg  ccctgctca  cctctggga  ccccgccct  cgcaggctt  120
tgtcaaaca  cacctttgt  gttctcact  ggtggaagc  ctctacctg  tgtgtgggg  180
gcgtggatt  ttctacaca  ccatgtccc  ccgcgaagt  gaggaccca  agtggcaca  240
ctggagctg  gtggaggcc  gggggcagg  gaccttcag  ccttggcac  ggaggtggc  300
cggcagaag  gcggcatcg  ggatcagtg  tgcaccagc  tctgctctc  ctaccaact  360
cagaactac  gcaactagg  ccaccacta  cctgtccac  cctctgcaa  gaataaaac  420
tttgaaaga  c  431



<210> 2562
<211> 110
<212> PRT
<213> Rattus norvegicus
<308> NP_062003
<400> 2562

Met Ala Leu Trp Ile Arg Phe Leu Pro Leu Leu Ala Leu Leu Ile Leu 
  1               5                  10                  15
Trp Glu Pro Arg Pro Ala Gln Ala Phe Val Lys Gln His Leu Cys Gly 
             20                  25                  30
Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
         35                  40                  45
Phe Tyr Thr Pro Met Ser Arg Arg Glu Val Glu Asp Pro Gln Val Ala 
     50                  55                  60
Gln Leu Glu Leu Gly Gly Gly Pro Gly Ala Gly Asp Leu Gln Thr Leu 
 65                  70                  75                  80
Ala Leu Glu Val Ala Arg Gln Lys Arg Gly Ile Val Asp Gln Cys Cys 
                 85                  90                  95
Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
             100                105                110



<210> 2563
<211> 450
<212> DNA
<213> Homo sapiens
<308> NM_000207
<400> 2563

gctgcatca  aagaggcca  caagcacat  actgtcctt  tgccatggc  ctgtggatg  60
gcctcctgc  cctgctggc  ctgctggcc  tctggggac  tgacccagc  gcagccttt  120
tgaaccaac  cctgtgcgg  tcacacctg  tggaagctc  ctacctagt  tgcggggaa  180
gaggcttct  ctacacacc  aagacccgc  gggaggcag  ggacctgca  gtggggcag  240
tggagctgg  cgggggccc  ggtgcaggc  gcctgcagc  cttggccct  gaggggtcc  300
tgcagaagc  tggcattgt  gaacaatgc  gtaccagca  ctgctccct  taccagctg  360
agaactact  caactagac  cagcccgca  gcagccccc  acccgccgc  tcctgcacc  420
agagagatg  aataaagcc  ttgaaccagc  450



<210> 2564
<211> 110
<212> PRT
<213> Homo sapiens
<308> P01308
<400> 2564

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
  1               5                  10                  15
Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
             20                  25                  30
Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
         35                  40                  45
Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
     50                  55                  60
Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
 65                  70                  75                  80
Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                 85                  90                  95
Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
             100                105                110



<210> 2565
<211> 1164
<212> DNA
<213> Rattus norvegicus
<308> J04943
<400> 2565

gtgtctgtt  tgcggaaca  taggcagtt  ttttccgtc  ggcttctct  acactcaag  60
gcgcgcctc  acctcatgg  agactcgat  gacatggac  tgagccctc  taggcctca  120
aactacctt  tcggttgtg  actaaaggc  gacaaagat  atcacttta  agtggataa  180
gatgaaaat  agcaccagt  atcattaag  acggtcagt  taggagcag  ggcaaaaga  240
gagttgcac  tcgtagagg  agaagcaat  aactatgaa  gcagcccaa  taaagtaac  300
ctggcaact  tgaaaatgt  tgtacaacc  acagtttcc  ttgggggct  cgaaattac  360
ccacctgtg  tcttgaggt  gaagtgtgg  tctgggcct  tgcacataa  tggacagca  420
ctagtagct  tagaggaag  tgcagagtc  gaagatgaa  atgaggaag  tgtaaaact  480
ttaggcatg  ctggaaaga  atctgctcc  ggaggtggt  acaaagtcc  acagaaaaa  540
gtaaaactt  atgaagatg  tgatgagga  gatgaagat  atgaggatg  tgaagatga  600
gatgatgat  attttgatg  agaggaaac  gaagaaaag  ttccagtga  gaaatctgt  660
cgagatacc  cagccaaaa  tgcacaaaa  tcaaaccaa  atgggaaag  tttaaaacc  720
tcaacacca  ggtcaaagg  tcaagagtc  ttcaaaaaa  aggaaaaaa  tcccaaaac  780
cccaaagga  ctagctctg  agaagacat  aaggcaaaa  tgcaagcaa  tatagaaaa  840
gcgcattga  cattcctgg  cactactgg  aaattaagc  caaagatgg  gaaagagga  900
aaggagaaa  aaatatagt  ccatcaaca  tccagactg  agtcttcta  tttaatctc  960
atccccttt  ctgattggc  atccattcc  ccttgcagg  tggaagcaa  cgaaaacct  1020
aagcatttt  ctttttcac  cgggtgatg  agaaaactt  actgctttt  tataccact  1080
gtgcatatg  cttaactct  accatgttt  aattttaac  tttgtatcc  tagctgctc  1140
aaataaatt  ttgaatgaa  caat  1164



<210> 2566
<211> 292
<212> PRT
<213> Rattus norvegicus
<308> P13084
<400> 2566

Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn 
  1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys 
             20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser 
         35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala 
     50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys 
 65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro 
                 85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser 
             100                105                110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu 
         115                120                125
Asp Glu Glu Asp Val Lys Leu Leu Gly Met Ser Gly Lys Arg Ser Ala 
     130                135                140
Pro Gly Gly Gly Asn Lys Val Pro Gln Lys Lys Val Lys Leu Asp Glu 
 145                150                155                160
Asp Asp Asp Glu Asp Asp Glu Asp Asp Glu Asp Asp Glu Asp Asp Asp 
                 165                170                175
Asp Asp Asp Phe Asp Glu Glu Glu Thr Glu Glu Lys Val Pro Val Lys 
             180                185                190
Lys Ser Val Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn Gln 
         195                200                205
Asn Gly Lys Asp Leu Lys Pro Ser Thr Pro Arg Ser Lys Gly Gln Glu 
     210                215                220
Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly Pro Ser 
 225                230                235                240
Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu Lys Gly 
                 245                250                255
Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val Lys Asn 
             260                265                270
Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp Gln Trp 
         275                280                285
Arg Lys Ser Leu 
     290



<210> 2567
<211> 467
<212> DNA
<213> Homo sapiens
<308> AL135691
<400> 2567

gaaaaaggt  gttctcttc  caaagtgga  gccaaattc  tcaattatg  gaagaattg  60
ttccggatg  ctgaccaag  ggctattca  gatctctgg  agtggagga  gtctcttta  120
gaaaatagt  taaacaatt  tttaacaaa  tttcctgtg  ttagcttgt  gaaatgttt  180
gcatctgtc  attaaggaa  aaaaaaatc  ctctatgtt  ccccacttt  gagccctgt  240
tgccaccct  tgttcctgt  attgcaatg  gagaccgaa  gtaatatgg  aaacctacc  300
gtggggtgt  gttgtgccc  gagcacgtg  gtaaaggac  ggggaggcg  gtcttgaaa  360
agcaactgc  gaaattcct  atgatgatt  tgtgcaagt  agttaacat  aaccttcat  420
tgtaaattt  ttaaaattt  ttttataat  tgctttccg  agtcctt  467



<210> 2568
<211> 294
<212> PRT
<213> Homo sapiens
<308> AAH12566
<400> 2568

Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn 
  1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys 
             20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser 
         35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala 
     50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys 
 65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro 
                 85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser 
             100                105                110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu 
         115                120                125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala 
     130                135                140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala 
 145                150                155                160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp 
                 165                170                175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val 
             180                185                190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn 
         195                200                205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly 
     210                215                220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly 
 225                230                235                240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu 
                 245                250                255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val 
             260                265                270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp 
         275                280                285
Gln Trp Arg Lys Ser Leu 
     290



<210> 2569
<211> 4507
<212> DNA
<213> Rattus norvegicus
<308> J05022
<400> 2569

cctgtagca  gtgctcatt  ccgggagca  cgcggactg  agccgcctc  gcggggaaa  60
atgctgcgg  agcggaccg  acggctgca  tacgggagc  gcgtggagg  ggtgtacgt  120
ctgggcacg  agctctgga  cgatgtcta  agtgcagcg  ctgctgggg  caaaacctt  180
agcctgaag  actcggagg  tgtgaaagt  gaggtcgtg  gcgatggag  ggcagagga  240
gtagtcacc  acggcaagc  gcgttgggc  ctgtcaccc  gcaccacac  gcgactcag  300
atggcccag  ccagcaccg  ggccagcag  gacaaggtc  ccgtcaact  ctatgaaga  360
gatggcagt  cccctattg  ccaggctgg  ctcttcctc  ctgccattg  gatctcact  420
gatgtggac  cagaccggg  cggagaagt  gagaagaat  atcctaaga  ggcatcctg  480
acctggggt  ctgagggcc  gggggccat  ctgctggtg  actgtgacc  agacacacc  540
tggttgccc  aggaggact  cagtgatga  aaggtctac  gcaaacaag  ccttcagga  600
atgtctcag  tgatcctga  gaccaaagg  cctgaccgc  tgcccgccg  gtatgaaat  660
gtcctctac  tttctatgt  ggactcgga  aaagtgggc  tgttctacg  ggagaaccc  720
ttctttggc  agcgctaca  ccacatcct  ggccggcag  agctctacc  cgtggtgaa  780
tacaccggt  gctctgcag  gttgctgtt  ttcgtggaa  gcctccgtt  cccagacga  840
agtttctca  gcctggttt  catccacgt  agtctgctg  agtatatgg  cgaggacat  900
ccattgaca  ccatcttca  agacaccgt  acgttccgg  ttgccccat  gattatgac  960
cccaacatc  tgcctcccg  gtcagtgtt  gtgtgctgc  tgaaggaca  ttacctgtt  1020
ctgaaagag  tgaagaacc  ggtggagaa  accaactgc  agctgaaag  ttgtttcca  1080
tacatgaat  gtggcgacc  ctggatcca  gatgaaatt  agtttggct  cattgaggc  1140
cctcacaaa  gcttcccag  agtgctgga  tcccctcga  atggaaacc  gaaggactt  1200
cccattaag  aactcctgg  cccagattt  ggctatgtg  cccgggagc  cctctttga  1260
actgtcacc  gccttgact  cttcgggaa  ctggaggtc  gtcccccag  gaccgtgaa  1320
ggcaaggca  acccgcttg  ccggatcct  atcgggagc  gtttccctc  gtctggagg  1380
aggaggatg  ccaaggtgg  gcgtgactt  ctgcaggcc  agcaggtgc  ggcgcccgt  1440
gaactctac  cggattggc  gactgtggg  cacgtcgat  agttcatga  cttcgtccc  1500
atcccaggc  aaaaggaat  tcggctgct  atggccagc  cctcagcct  ctaccagct  1560
ttcagagaa  agcagaagg  aggccacgg  gaggccatt  tgttcaagg  tctgggggg  1620
atgagcagc  aacgaatca  catcaataa  atcctgtcc  atgagagcc  cacgcagga  1680
aaccagtac  ttcagcgct  tctggattg  aaccgtgac  tccttaaga  ggagctggc  1740
ctgactgag  aggacatca  tgacctgcc  gctctcttc  agatggatg  agaccgtca  1800
gccagggct  tcttcccta  catggtgaa  atgatcgtg  tagacaagg  cctgggtat  1860
cccaagcct  tcgggcccc  ggtcgagga  gagtgctgc  tggagacac  tgttcgagg  1920
ctgctggag  ccctgggcc  tgcctgcac  ttcattgat  acatctctg  ataccacaa  1980
tttctggga  aggttcact  tggcaccaa  gtgcgcagg  agcccttca  cttcaagtg  2040
tggcacatg  tgccctgac  gccaggggc  ctggccttc  ttccttccc  gcgatctcc  2100
ggtccttcc  gtgtcccca  gtccttccc  tacaagaag  gggtgggat  gggattgtg  2160
cttgctgtc  cctggagaa  gactttagt  tccattgaa  ccaccccga  taagtccaa  2220
cgttcccta  ccctgaaaa  agctagaca  gtggttagt  tgcagaact  tggaaggga  2280
aaccagact  caacaaatc  tgtagtcgc  ctgtccccc  aagaattct  agcctctac  2340
ccagatcag  aggagggga  agagaaggg  gactctgag  tcattggct  gcccagcac  2400
catctgaca  tcaagatag  ccaggagga  cagggccag  gtcctggcg  acctcggat  2460
gtaccatct  ttcaagctt  cctaccttg  ggcctcctg  tcggatcct  cgcccattc  2520
ttccttaag  cttcccata  acactgtgt  cccacccca  ccccacccc  tgagggtcc  2580
atcattcag  ttagaatca  ccggaaatg  gtcttagca  aggagaggt  ttcactttc  2640
gtggattcg  gctgcccaa  tttgggagg  cggggaggt  tcggactag  atccgatgt  2700
caaagttca  tagacaaag  tgcacctgt  tatcgacac  atttctgtt  tctcccccg  2760
tcctcagtt  tctggccag  ccgtgagcc  ctctttcca  tgttcttct  tttctgaca  2820
tggccttcc  attctggat  ttgcccctc  agcagctac  gtttcttca  caccagcca  2880
attcaggcc  cccgagggc  tgagaagta  ccaatccca  tgtccaagg  tgctgagga  2940
gctggcaat  ccccagcct  actgatcac  tcccggcta  ctactgctc  agaggcaga  3000
ttttccagc  cactttccg  aggccttcc  tccagatac  ggcaaatgg  tcccccctc  3060
cccaacctg  ttcatttag  aaggcctcc  ggagctgta  agatggctc  gcagttaaa  3120
atgctccct  ctcttcaag  ggacccaag  tcagttccc  acacccacg  tgctctgta  3180
ctccagatc  agaggatcc  atacccttt  ctggtctct  agggcactt  acgcatgtg  3240
acaaaccca  agacataaa  caatgtttg  gagtctgga  agatggccc  gtggttaaa  3300
gcacttgct  ctcttgcgg  ggacctggg  tcagttctc  gcacccagt  ggtggctca  3360
aaccaacta  aactctagt  ccagggggt  cgatgctct  ctctgacct  cataggctt  3420
tgcacacag  tggttcaca  acacaccct  aagcacaca  acaagtaaa  taaagtaaa  3480
gatgcttaa  aaatagaaa  aaggaaaat  tgtctctta  aatagagaa  gtcctttta  3540
ggccaagaa  gtaggaaat  gtaattctg  tttggaggg  taaacggtc  cattttata  3600
ctgaagaaa  gggttacac  cacattctt  ggggaacaa  atttttacc  tgcattatt  3660
cctcagtag  ttgtatgct  ctgagtagt  ggcacagac  tggacgctg  taacacaag  3720
tagccatag  ctcgcttgt  ccaacagac  aaacccacg  ctgcatagc  accctccgc  3780
cttgctgtg  taacactac  cagtatatt  aagaagcat  caggacaac  gtcactgcc  3840
tcaacaatt  ggaggtgtc  tcttttctg  ccagctggc  taatgcacc  tgccaggtc  3900
ggccccaga  cctccaaag  tgtcatcct  tgtctctgg  gacagaggt  cctgccctt  3960
agggcaaag  cccaaatcc  gtctcctgc  ccagagtgg  aaacacagg  acctctctg  4020
gggaggtgg  ctggggatg  ggcggtttg  cgtgtgtgg  gttccgtta  agtggcttt  4080
actgctttt  tttttatct  cgttaagag  aagtgagcc  tccccacgt  gaggccacg  4140
cgtgtcttt  gtaggttgt  ttggtgttt  gggaatttc  ggaactcca  gactccgcc  4200
gtcccatct  acttactca  ccagtgtga  cccctcaag  gtggacgcc  catcccgag  4260
actccttgc  cttctccac  tccattgtt  gttggtgtt  ttttttttt  aacttatgc  4320
cagaggctt  tgggctatg  cagttcctg  ttcaatgtt  attttgaaa  gctctgctg  4380
gggtggggg  aacggcagg  agatggcgg  aatggggca  tatgaactt  ctggaaaaa  4440
agccaagat  gagtctgag  agtgtctgg  ggaagagcc  aaataaaga  caataaaat  4500
agccgtc  4507



<210> 2570
<211> 665
<212> PRT
<213> Rattus norvegicus
<308> P20717
<400> 2570

Met Leu Arg Glu Arg Thr Val Arg Leu Gln Tyr Gly Ser Arg Val Glu 
  1               5                  10                  15
Ala Val Tyr Val Leu Gly Thr Gln Leu Trp Thr Asp Val Tyr Ser Ala 
             20                  25                  30
Ala Pro Ala Gly Ala Lys Thr Phe Ser Leu Lys His Ser Glu Gly Val 
         35                  40                  45
Lys Val Glu Val Val Arg Asp Gly Glu Ala Glu Glu Val Val Thr Asn 
     50                  55                  60
Gly Lys Gln Arg Trp Ala Leu Ser Pro Ser Thr Thr Leu Arg Leu Ser 
 65                  70                  75                  80
Met Ala Gln Ala Ser Thr Glu Ala Ser Ser Asp Lys Val Thr Val Asn 
                 85                  90                  95
Tyr Tyr Glu Glu Asp Gly Ser Ala Pro Ile Asp Gln Ala Gly Leu Phe 
             100                105                110
Leu Thr Ala Ile Glu Ile Ser Leu Asp Val Asp Ala Asp Arg Asp Gly 
         115                120                125
Glu Val Glu Lys Asn Asn Pro Lys Lys Ala Ser Trp Thr Trp Gly Pro 
     130                135                140
Glu Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Thr Pro 
 145                150                155                160
Trp Leu Pro Lys Glu Asp Cys Ser Asp Glu Lys Val Tyr Ser Lys Gln 
                 165                170                175
Asp Leu Gln Asp Met Ser Gln Met Ile Leu Arg Thr Lys Gly Pro Asp 
             180                185                190
Arg Leu Pro Ala Gly Tyr Glu Ile Val Leu Tyr Ile Ser Met Ser Asp 
         195                200                205
Ser Asp Lys Val Gly Val Phe Tyr Val Glu Asn Pro Phe Phe Gly Gln 
     210                215                220
Arg Tyr Ile His Ile Leu Gly Arg Gln Lys Leu Tyr His Val Val Lys 
 225                230                235                240
Tyr Thr Gly Gly Ser Ala Glu Leu Leu Phe Phe Val Glu Gly Leu Arg 
                 245                250                255
Phe Pro Asp Glu Ser Phe Ser Gly Leu Val Ser Ile His Val Ser Leu 
             260                265                270
Leu Glu Tyr Met Ala Glu Asp Ile Pro Leu Thr Pro Ile Phe Thr Asp 
         275                280                285
Thr Val Thr Phe Arg Ile Ala Pro Trp Ile Met Thr Pro Asn Ile Leu 
     290                295                300
Pro Pro Val Ser Val Phe Val Cys Cys Met Lys Asp Asn Tyr Leu Phe 
 305                310                315                320
Leu Lys Glu Val Lys Asn Leu Val Glu Lys Thr Asn Cys Glu Leu Lys 
                 325                330                335
Val Cys Phe Gln Tyr Met Asn Arg Gly Asp Arg Trp Ile Gln Asp Glu 
             340                345                350
Ile Glu Phe Gly Tyr Ile Glu Ala Pro His Lys Gly Phe Pro Val Val 
         355                360                365
Leu Asp Ser Pro Arg Asp Gly Asn Leu Lys Asp Phe Pro Ile Lys Gln 
     370                375                380
Leu Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Leu Phe Glu 
 385                390                395                400
Thr Val Thr Ser Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro 
                 405                410                415
Val Thr Val Asn Gly Lys Ala Tyr Pro Leu Gly Arg Ile Leu Ile Gly 
             420                425                430
Ser Ser Phe Pro Leu Ser Gly Gly Arg Arg Met Thr Lys Val Val Arg 
         435                440                445
Asp Phe Leu Gln Ala Gln Gln Val Gln Ala Pro Val Glu Leu Tyr Ser 
     450                455                460
Asp Trp Leu Thr Val Gly His Val Asp Glu Phe Met Thr Phe Val Pro 
 465                470                475                480
Ile Pro Gly Lys Lys Glu Phe Arg Leu Leu Met Ala Ser Thr Ser Ala 
                 485                490                495
Cys Tyr Gln Leu Phe Arg Glu Lys Gln Lys Glu Gly His Gly Glu Ala 
             500                505                510
Ile Met Phe Lys Gly Leu Gly Gly Met Ser Ser Lys Arg Ile Thr Ile 
         515                520                525
Asn Lys Ile Leu Ser Asn Glu Ser Leu Thr Gln Glu Asn Gln Tyr Phe 
     530                535                540
Gln Arg Cys Leu Asp Trp Asn Arg Asp Ile Leu Lys Lys Glu Leu Ala 
 545                550                555                560
Leu Thr Glu Lys Asp Ile Ile Asp Leu Pro Ala Leu Phe Lys Met Asp 
                 565                570                575
Glu Asp Arg Gln Ala Arg Ala Phe Phe Pro Asn Met Val Asn Met Ile 
             580                585                590
Val Leu Asp Lys Asp Leu Gly Ile Pro Lys Pro Phe Gly Pro Gln Val 
         595                600                605
Glu Glu Glu Cys Cys Leu Glu Thr His Val Arg Gly Leu Leu Glu Pro 
     610                615                620
Leu Gly Leu Ala Cys Thr Phe Ile Asp Asp Ile Ser Ala Tyr His Lys 
 625                630                635                640
Phe Leu Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe 
                 645                650                655
Thr Phe Lys Trp Trp His Met Val Pro 
             660                665



<210> 2571
<211> 1626
<212> DNA
<213> Homo sapiens
<308> BC009701
<400> 2571

cgcacctgc  gcaggtgct  ccggccgcc  cggaccagc  agcgcgggc  ctgcggcgg  60
gaggatgct  cgcgagcgg  ccgtgcggc  gcagtacgg  agccgcgtg  aggcggtgt  120
cgtgctggg  acctacctc  ggaccgatg  ctacagcgc  gccccagcc  gggcccaaa  180
cttcagcct  aagcactcg  aacacgtgt  ggtggaggt  gtgcgtgat  gggaggctg  240
ggaggtggc  accaatggc  agcagcgct  gcttctctc  cccagcacc  ccctgcggg  300
caccatgag  caggcgagc  ccgaggcca  cagtgacaa  gtcaccgtc  actactatg  360
cgaggaagg  agcattccc  tcgaccagg  ggggctctt  ctcacagcc  ttgagatct  420
cctggatgt  gacgcagac  gggatggtg  ggtggagaa  aacaaccca  agaaggcat  480
ctggacctg  ggccccgag  gccaggggg  catcctgct  gtgaactgt  accgagaga  540
accctggtt  cccaaggag  actgccgtg  tgagaaggt  tacagcaag  aagatctca  600
ggacatgtc  cagatgatc  tgcggacca  aggccccga  cgcctcccc  ccggatacg  660
gatagttct  tacatttcc  tgtcagact  agacaaagt  ggcgtgttc  acgtggaga  720
cccgttctt  ggccaacgc  atatccaca  cctgggccg  cggaagctc  accatgtgg  780
caagtacac  ggtggctcc  cggagctgc  gttcttcgt  gaaggcctc  gtttccccg  840
cgagggctt  tcaggcctg  tctccatcc  tgtcagcct  ctggagtac  tggcccagg  900
cattcccct  actcccatc  tcacggaca  cgtgatatt  cggattgct  cgtggatca  960
gacccccaa  atcctgcct  ccgtgtcgg  gtttgtgtg  tgcatgaag  ataattacc  1020
gttcctgaa  gaggtgaag  accttgtgg  gaaaaccaa  tgtgagctg  aggtctgct  1080
ccagtacct  aaccgaggc  atcgctgga  ccaggatga  attgagttt  gctacatcg  1140
ggcccccca  aaaggcttc  ccgtggtgc  ggactctcc  cgagatgga  acctaaagg  1200
cttccctgt  aaggagctc  tgggcccag  ttttggcta  gtgacccgg  agcccctct  1260
tgagtctgt  accagcctt  actcatttg  aaacctgga  gtcagtccc  cagtgaccg  1320
gaatggcaa  acatacccg  ttggccgca  cctcatcgg  agcagcttt  ctctgtaag  1380
gaagccagg  tggggctag  ggctgtggg  gtggggaag  cactgtttc  cttttgggg  1440
ggcctgggt  gctcacaca  ggagcaagt  gctggggga  ttattccct  ccacgactt  1500
ctgttaaga  gccgacact  ttggaaaga  aatcaagct  gcctttata  ctttgtgtg  1560
tttaggatc  aatatataa  taaataaac  actcttttc  ccaagtgaa  aaaaaaaaa  1620
aaaaaa  1626



<210> 2572
<211> 665
<212> PRT
<213> Homo sapiens
<308> Q9Y2J8
<400> 2572

Met Leu Arg Glu Arg Thr Val Arg Leu Gln Tyr Gly Ser Arg Val Glu 
  1               5                  10                  15
Ala Val Tyr Val Leu Gly Thr Tyr Leu Trp Thr Asp Val Tyr Ser Ala 
             20                  25                  30
Ala Pro Ala Gly Ala Gln Thr Phe Ser Leu Lys His Ser Glu His Val 
         35                  40                  45
Trp Val Glu Val Val Arg Asp Gly Glu Ala Glu Glu Val Ala Thr Asn 
     50                  55                  60
Gly Lys Gln Arg Trp Leu Leu Ser Pro Ser Thr Thr Leu Arg Val Thr 
 65                  70                  75                  80
Met Ser Gln Ala Ser Thr Glu Ala Ser Ser Asp Lys Val Thr Val Asn 
                 85                  90                  95
Tyr Tyr Asp Glu Glu Gly Ser Ile Pro Ile Asp Gln Ala Gly Leu Phe 
             100                105                110
Leu Thr Ala Ile Glu Ile Ser Leu Asp Val Asp Ala Asp Arg Asp Gly 
         115                120                125
Val Val Glu Lys Asn Asn Pro Lys Lys Ala Ser Trp Thr Trp Gly Pro 
     130                135                140
Glu Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Glu Thr Pro 
 145                150                155                160
Trp Leu Pro Lys Glu Asp Cys Arg Asp Glu Lys Val Tyr Ser Lys Glu 
                 165                170                175
Asp Leu Lys Asp Met Ser Gln Met Ile Leu Arg Thr Lys Gly Pro Asp 
             180                185                190
Arg Leu Pro Ala Gly Tyr Glu Ile Val Leu Tyr Ile Ser Met Ser Asp 
         195                200                205
Ser Asp Lys Val Gly Val Phe Tyr Val Glu Asn Pro Phe Phe Gly Gln 
     210                215                220
Arg Tyr Ile His Ile Leu Gly Arg Arg Lys Leu Tyr His Val Val Lys 
 225                230                235                240
Tyr Thr Gly Gly Ser Ala Glu Leu Leu Phe Phe Val Glu Gly Leu Cys 
                 245                250                255
Phe Pro Asp Glu Gly Phe Ser Gly Leu Val Ser Ile His Val Ser Leu 
             260                265                270
Leu Glu Tyr Met Ala Gln Asp Ile Pro Leu Thr Pro Ile Phe Thr Asp 
         275                280                285
Thr Val Ile Phe Arg Ile Ala Pro Trp Ile Met Thr Pro Asn Ile Leu 
     290                295                300
Pro Pro Val Ser Val Phe Val Cys Cys Met Lys Asp Asn Tyr Leu Phe 
 305                310                315                320
Leu Lys Glu Val Lys Asn Leu Val Glu Lys Thr Asn Cys Glu Leu Lys 
                 325                330                335
Val Cys Phe Gln Tyr Leu Asn Arg Gly Asp Arg Trp Ile Gln Asp Glu 
             340                345                350
Ile Glu Phe Gly Tyr Ile Glu Ala Pro His Lys Gly Phe Pro Val Val 
         355                360                365
Leu Asp Ser Pro Arg Asp Gly Asn Leu Lys Asp Phe Pro Val Lys Glu 
     370                375                380
Leu Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Leu Phe Glu 
 385                390                395                400
Ser Val Thr Ser Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro 
                 405                410                415
Val Thr Val Asn Gly Lys Thr Tyr Pro Leu Gly Arg Ile Leu Ile Gly 
             420                425                430
Ser Ser Phe Pro Leu Ser Gly Gly Arg Arg Met Thr Lys Val Val Arg 
         435                440                445
Asp Phe Leu Lys Ala Gln Gln Val Gln Ala Pro Val Glu Leu Tyr Ser 
     450                455                460
Asp Trp Leu Thr Val Gly His Val Asp Glu Phe Met Ser Phe Val Pro 
 465                470                475                480
Ile Pro Gly Thr Lys Lys Phe Leu Leu Leu Met Ala Ser Thr Ser Ala 
                 485                490                495
Cys Tyr Lys Leu Phe Arg Glu Lys Gln Lys Asp Gly His Gly Glu Ala 
             500                505                510
Ile Met Phe Lys Gly Leu Gly Gly Met Ser Ser Lys Arg Ile Thr Ile 
         515                520                525
Asn Lys Ile Leu Ser Asn Glu Ser Leu Val Gln Glu Asn Leu Tyr Phe 
     530                535                540
Gln Arg Cys Leu Asp Trp Asn Arg Asp Ile Leu Lys Lys Glu Leu Gly 
 545                550                555                560
Leu Thr Glu Gln Asp Ile Ile Asp Leu Pro Ala Leu Phe Lys Met Asp 
                 565                570                575
Glu Asp His Arg Ala Arg Ala Phe Phe Pro Asn Met Val Asn Met Ile 
             580                585                590
Val Leu Asp Lys Asp Leu Gly Ile Pro Lys Pro Phe Gly Pro Gln Val 
         595                600                605
Glu Glu Glu Cys Cys Leu Glu Met His Val Arg Gly Leu Leu Glu Pro 
     610                615                620
Leu Gly Leu Glu Cys Thr Phe Ile Asp Asp Ile Ser Ala Tyr His Lys 
 625                630                635                640
Phe Leu Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe 
                 645                650                655
Thr Phe Lys Trp Trp His Met Val Pro 
             660                665



<210> 2574
<211> 430
<212> PRT
<213> Rattus norvegicus
<308> P15650
<400> 2574

Met Ala Ala Arg Leu Leu Leu Arg Ser Leu Arg Val Leu Ser Ala Arg 
  1               5                  10                  15
Ser Ala Thr Leu Pro Pro Pro Ser Ala Arg Cys Ser His Ser Gly Ala 
             20                  25                  30
Glu Ala Arg Leu Glu Thr Pro Ser Ala Lys Lys Leu Thr Asp Ile Gly 
         35                  40                  45
Ile Arg Arg Ile Phe Ser Ser Glu His Asp Ile Phe Arg Glu Ser Val 
     50                  55                  60
Arg Lys Phe Phe Gln Glu Glu Val Ile Pro Tyr His Glu Glu Trp Glu 
 65                  70                  75                  80
Lys Ala Gly Glu Val Ser Arg Glu Leu Trp Glu Lys Ala Gly Lys Gln 
                 85                  90                  95
Gly Leu Leu Gly Ile Asn Ile Ala Glu Lys His Gly Gly Ile Gly Gly 
             100                105                110
Asp Leu Leu Ser Thr Ala Val Thr Trp Glu Glu Gln Ala Tyr Ser Asn 
         115                120                125
Cys Thr Gly Pro Gly Phe Ser Leu His Ser Asp Ile Val Met Pro Tyr 
     130                135                140
Ile Ala Asn Tyr Gly Thr Lys Glu Gln Ile Glu Gln Phe Ile Pro Gln 
 145                150                155                160
Met Thr Ala Gly Lys Cys Ile Gly Ala Ile Ala Met Thr Glu Pro Gly 
                 165                170                175
Ala Gly Ser Asp Leu Gln Gly Val Arg Thr Asn Ala Lys Arg Ser Gly 
             180                185                190
Ser Asp Trp Ile Leu Asn Gly Ser Lys Val Phe Ile Thr Asn Gly Trp 
         195                200                205
Leu Ser Asp Leu Val Ile Val Val Ala Val Thr Asn Arg Glu Ala Arg 
     210                215                220
Ser Pro Ala His Gly Ile Ser Leu Phe Leu Val Glu Asn Gly Met Lys 
 225                230                235                240
Gly Phe Ile Lys Gly Lys Lys Leu His Lys Met Gly Met Lys Ala Gln 
                 245                250                255
Asp Thr Ala Glu Leu Phe Phe Glu Asp Val Arg Leu Pro Ala Ser Ala 
             260                265                270
Leu Leu Gly Glu Glu Asn Lys Gly Phe Tyr Tyr Leu Met Gln Glu Leu 
         275                280                285
Pro Gln Glu Arg Leu Leu Ile Ala Asp Leu Ala Ile Ser Ala Cys Glu 
     290                295                300
Phe Met Phe Glu Glu Thr Arg Asn Tyr Val Arg Gln Arg Lys Ala Phe 
 305                310                315                320
Gly Lys Thr Val Ala His Ile Gln Thr Val Gln His Lys Leu Ala Glu 
                 325                330                335
Leu Lys Thr Asn Ile Cys Val Thr Arg Ala Phe Val Asp Ser Cys Leu 
             340                345                350
Gln Leu His Glu Thr Lys Arg Leu Asp Ser Ala Ser Ala Ser Met Ala 
         355                360                365
Lys Tyr Trp Ala Ser Glu Leu Gln Asn Thr Val Ala Tyr Gln Cys Val 
     370                375                380
Gln Leu His Gly Gly Trp Gly Tyr Met Trp Glu Tyr Pro Ile Ala Lys 
 385                390                395                400
Ala Tyr Val Asp Ala Arg Val Gln Pro Ile Tyr Gly Gly Thr Asn Glu 
                 405                410                415
Ile Met Lys Glu Leu Ile Ala Arg Gln Ile Val Ser Asp Ser 
             420                425                430



<210> 2575
<211> 2217
<212> DNA
<213> Homo sapiens
<308> M74096
<400> 2575

cggacatgg  cgcacgcct  ctccgaggg  ccctacgcg  cctgggcgg  caccgtgcg  1500
cgcgccagc  gcccgccgc  cgatgttct  attccggag  ggaagaacg  ctagaaact  1560
cttctgcta  aaaattaac  gatatagga  ttcgaagaa  cttttctcc  gagcatgac  1620
ttttccgga  aagtgtaag  aagtttttc  aagaagaag  gattcctca  cactcagaa  1680
gggagaaag  tggagaagt  agtagggag  tttgggaaa  agctggaaa  caaggactg  1740
ttggtgtca  tattgcaga  catcttggt  gaattggag  ggatctgta  tccgcagct  1800
ttgtctggg  ggagcaagc  tattcaaat  gttcaggcc  aggttttag  attcattca  1860
gtattgtca  gtcctatat  acaaaccat  gctcagaag  acagattaa  cactttatt  1920
cccagatga  tgcaggcaa  tgtattggt  caatagcaa  gacagagcc  ggagctgga  1980
gtgacttac  gggaataaa  acaaatgct  aaaaggatg  aagtgactg  attctcaat  2040
gaagcaagg  gttcatcag  aatgggtca  taagtgatg  tgtgattgt  gttgcggtc  2100
caaatcatg  agctccctc  cctgcccat  gtattagcc  ttttctggt  gaaaatgga  2160
tgaaaggat  tatcaaggg  cgaaagcta  ataaaatgg  attaaaagc  caggata  2217



<210> 2576
<211> 430
<212> PRT
<213> Homo sapiens
<308> P28330
<400> 2576

Met Ala Ala Arg Leu Leu Arg Gly Ser Leu Arg Val Leu Gly Gly His 
  1               5                  10                  15
Arg Ala Pro Arg Gln Leu Pro Ala Ala Arg Cys Ser His Ser Gly Gly 
             20                  25                  30
Glu Glu Arg Leu Glu Thr Pro Ser Ala Lys Lys Leu Thr Asp Ile Gly 
         35                  40                  45
Ile Arg Arg Ile Phe Ser Pro Glu His Asp Ile Phe Arg Lys Ser Val 
     50                  55                  60
Arg Lys Phe Phe Gln Glu Glu Val Ile Pro His His Ser Glu Trp Glu 
 65                  70                  75                  80
Lys Ala Gly Glu Val Ser Arg Glu Val Trp Glu Lys Ala Gly Lys Gln 
                 85                  90                  95
Gly Leu Leu Gly Val Asn Ile Ala Glu His Leu Gly Gly Ile Gly Gly 
             100                105                110
Asp Leu Tyr Ser Ala Ala Ile Val Trp Glu Glu Gln Ala Tyr Ser Asn 
         115                120                125
Cys Ser Gly Pro Gly Phe Ser Ile His Ser Gly Ile Val Met Ser Tyr 
     130                135                140
Ile Thr Asn His Gly Ser Glu Glu Gln Ile Lys His Phe Ile Pro Gln 
 145                150                155                160
Met Thr Ala Gly Lys Cys Ile Gly Ala Ile Ala Met Thr Glu Pro Gly 
                 165                170                175
Ala Gly Ser Asp Leu Gln Gly Ile Lys Thr Asn Ala Lys Lys Asp Gly 
             180                185                190
Ser Asp Trp Ile Leu Asn Gly Ser Lys Val Phe Ile Ser Asn Gly Ser 
         195                200                205
Leu Ser Asp Val Val Ile Val Val Ala Val Thr Asn His Glu Ala Pro 
     210                215                220
Ser Pro Ala His Gly Ile Ser Leu Phe Leu Val Glu Asn Gly Met Lys 
 225                230                235                240
Gly Phe Ile Lys Gly Arg Lys Leu His Lys Met Gly Leu Lys Ala Gln 
                 245                250                255
Asp Thr Ala Glu Leu Phe Phe Glu Asp Ile Arg Leu Pro Ala Ser Ala 
             260                265                270
Leu Leu Gly Glu Glu Asn Lys Gly Phe Tyr Tyr Ile Met Lys Glu Leu 
         275                280                285
Pro Gln Glu Arg Leu Leu Ile Ala Asp Val Ala Ile Ser Ala Thr Glu 
     290                295                300
Phe Met Phe Glu Glu Thr Arg Asn Tyr Val Lys Gln Arg Lys Ala Phe 
 305                310                315                320
Gly Lys Thr Val Ala His Leu Gln Thr Val Gln His Gln Leu Ala Glu 
                 325                330                335
Leu Lys Thr His Ile Cys Val Thr Arg Ala Phe Val Asp Asn Cys Leu 
             340                345                350
Gln Leu His Glu Ala Lys Arg Leu Asp Ser Ala Thr Ala Cys Met Ala 
         355                360                365
Lys Tyr Trp Ala Ser Glu Leu Gln Asn Ser Val Ala Tyr Asp Cys Val 
     370                375                380
Gln Leu His Gly Gly Trp Gly Tyr Met Trp Glu Tyr Pro Ile Ala Lys 
 385                390                395                400
Ala Tyr Val Asp Ala Arg Val Gln Pro Ile Tyr Gly Gly Thr Asn Glu 
                 405                410                415
Ile Met Lys Glu Leu Ile Ala Arg Glu Ile Val Phe Asp Lys 
             420                425                430



<210> 2577
<211> 2104
<212> DNA
<213> Rattus norvegicus
<308> J05031
<400> 2577

tggtataca  cggagatgg  gactgcagt  cggctgctg  ggcggcgag  ttccagttg  60
agactgcgg  ctttaccgt  gccccttgc  gtcccgcag  gggcccact  gatgttgcc  120
gtggatgat  atatcaacg  gctaaacga  gagcagaag  agcttcgtc  tacgatatc  180
aagttcgtt  aagagaacc  ggcccccaa  gcccaagag  ttgatcaaa  caatgactt  240
aagaacctg  gagagttct  gaagcagct  ggaagcctg  gagtcctgg  catcacagc  300
cccgttcag  atggtggct  tggcctggg  tacctagaa  atgtgttgg  gatggaaga  360
atatcccgg  cttcagcag  tgtggggct  agctatggc  ctcactcca  cctctgcat  420
aaccagatt  tccgcaatg  gaatgaggc  cagaaagag  aatatcttc  caagctcat  480
agtggtgag  tcatcggag  cctggccat  agtgagccc  acgctggct  tgacgttgt  540
tccatgagg  tgaaagcag  gaagaaagg  gatcactac  ttctgaatg  caacaagtt  600
tggatcacc  atggccctg  cgctgatgt  ctagttgtc  atgccaaga  agacttgac  660
gctgtgcct  cgtctcggg  catcacagc  ttcattgtg  aaaaggata  gcctggttt  720
agcacctcg  agaagctgg  caagctagg  atgaggggc  ccaacacct  tgagctagt  780
tttgaagac  gcaaggttc  tgctgctaa  atcctgagc  aagagagta  gggtgtcta  840
gtactgatg  gcgggctgg  cctagaacg  ctggtgctg  caggtggac  ccttgggat  900
atgcaggct  tcctggacc  caccattcc  tatttgcat  tgagggaag  ctttggcca  960
aagatcggc  aattccagc  gatgcaggg  aagatggct  acatgtaca  ccgcctcat  1020
gcatgtcga  agtatgtct  caatgtcgc  agggcctgt  acgagggcc  catcactgc  1080
aaggactgt  ctggtgtga  tctgtatac  gccgagtgt  ccacacaag  agccctgga  1140
ggcattcaa  gtttaggtg  aaatggcta  atcaatgac  tccccatgg  ccgctttct  1200
cgagatgcc  aactgtacg  gatcggagg  gggaccagt  aggtgaggc  gctagtcat  1260
ggcagagct  tcaacgcag  cttccgcta  cctggggcc  tcaccctgc  cccagcagc  1320
ggaggcctt  ggaagcaga  acgtggcag  cctctgact  ggctaagga  gctctgctg  1380
tcaactgcc  tcttgccag  cctctgctc  tcgtgaagt  ggattctcc  gccgtgcca  1440
ccagtcaat  aagaaagcc  aaaattcgg  ccccagctc  gaaaaaaaa  aaaaaaaaa  1500
agaaccaaa  gaaagccta  aatggctgc  aaaaggact  tggcttttc  ggggtttgc  1560
gggagggta  cagtgtctg  gcccttgtt  tctacttct  aatgtagta  cctcaccct  1620
tggggtagc  tatgacagg  acccaactc  ttttcgtgg  caagcctct  gcaggggag  1680
tctttctgt  gcaatgtaa  agaggcatt  cctctttca  ttgtcagat  cttgtggtc  1740
cttttcttg  ggaaaaggc  aaaaccatg  ccttcttag  tgtttcccc  agagctagc  1800
agacagttc  agaatgcct  tgtggcaga  ccatgaagg  cagagtcca  agtctagcc  1860
agacaactt  gagattggc  ccctggtgt  gctgagtgt  tacatcact  cgtcacagg  1920
tagcactgg  cctgctcac  tgaccttct  cagctgcct  actccggtg  cccagctta  1980
gttgcctgg  tcaactcca  ccttgctgt  tatgtatat  tctctagac  ccctgtggc  2040
aattttgtt  caaccacac  ggctctgct  ccattttgt  ttaaacata  tgcaaagta  2100
aaaa  2104



<210> 2578
<211> 424
<212> PRT
<213> Rattus norvegicus
<308> P12007
<400> 2578

Met Ala Thr Ala Val Arg Leu Leu Gly Arg Arg Val Ser Ser Trp Arg 
  1               5                  10                  15
Leu Arg Pro Leu Pro Ser Pro Leu Ala Val Pro Gln Arg Ala His Ser 
             20                  25                  30
Met Leu Pro Val Asp Asp Asp Ile Asn Gly Leu Asn Glu Glu Gln Lys 
         35                  40                  45
Gln Leu Arg His Thr Ile Ser Lys Phe Val Gln Glu Asn Leu Ala Pro 
     50                  55                  60
Lys Ala Gln Glu Ile Asp Gln Ser Asn Asp Phe Lys Asn Leu Arg Glu 
 65                  70                  75                  80
Phe Trp Lys Gln Leu Gly Ser Leu Gly Val Leu Gly Ile Thr Ala Pro 
                 85                  90                  95
Val Gln Tyr Gly Gly Ser Gly Leu Gly Tyr Leu Glu His Val Leu Val 
             100                105                110
Met Glu Glu Ile Ser Arg Ala Ser Ala Ala Val Gly Leu Ser Tyr Gly 
         115                120                125
Ala His Ser Asn Leu Cys Ile Asn Gln Ile Val Arg Asn Gly Asn Glu 
     130                135                140
Ala Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ile Ser Gly Glu Phe Ile 
 145                150                155                160
Gly Ala Leu Ala Met Ser Glu Pro Asn Ala Gly Ser Asp Val Val Ser 
                 165                170                175
Met Arg Leu Lys Ala Glu Lys Lys Gly Asp His Tyr Val Leu Asn Gly 
             180                185                190
Asn Lys Phe Trp Ile Thr Asn Gly Pro Asp Ala Asp Val Leu Val Val 
         195                200                205
Tyr Ala Lys Thr Asp Leu Thr Ala Val Pro Ala Ser Arg Gly Ile Thr 
     210                215                220
Ala Phe Ile Val Glu Lys Asp Met Pro Gly Phe Ser Thr Ser Lys Lys 
 225                230                235                240
Leu Asp Lys Leu Gly Met Arg Gly Ser Asn Thr Cys Glu Leu Val Phe 
                 245                250                255
Glu Asp Cys Lys Val Pro Ala Ala Asn Ile Leu Ser Gln Glu Ser Lys 
             260                265                270
Gly Val Tyr Val Leu Met Ser Gly Leu Asp Leu Glu Arg Leu Val Leu 
         275                280                285
Ala Gly Gly Pro Leu Gly Ile Met Gln Ala Val Leu Asp His Thr Ile 
     290                295                300
Pro Tyr Leu His Val Arg Glu Ala Phe Gly Gln Lys Ile Gly Gln Phe 
 305                310                315                320
Gln Leu Met Gln Gly Lys Met Ala Asp Met Tyr Thr Arg Leu Met Ala 
                 325                330                335
Cys Arg Gln Tyr Val Tyr Asn Val Ala Arg Ala Cys Asp Glu Gly His 
             340                345                350
Ile Thr Ala Lys Asp Cys Ala Gly Val Ile Leu Tyr Thr Ala Glu Cys 
         355                360                365
Ala Thr Gln Val Ala Leu Asp Gly Ile Gln Cys Leu Gly Gly Asn Gly 
     370                375                380
Tyr Ile Asn Asp Phe Pro Met Gly Arg Phe Leu Arg Asp Ala Lys Leu 
 385                390                395                400
Tyr Glu Ile Gly Gly Gly Thr Ser Glu Val Arg Arg Leu Val Ile Gly 
                 405                410                415
Arg Ala Phe Asn Ala Asp Phe Arg 
             420



<210> 2579
<211> 2562
<212> DNA
<213> Homo sapiens
<308> AK022777
<400> 2579

gttgtgcca  gctgctctg  catgtttgg  acgtgaatc  tccctttgt  cagcctatc  60
atgctatgt  ggctacctg  ccgttagta  tcacctagg  tatccaatc  gctgtcctg  120
tatcagagt  cctgtgttc  agtaactct  attttgctc  gtggcccca  attgcaaga  180
tagtgatgc  ggcatgtca  aatagttct  ttttagtat  tgttattat  gttgatctg  240
tactatgcc  agctcataa  ttaaacttt  tcataagta  gtatgtata  ggaaaaaaa  300
aacatatat  tgggtttcg  ttctatcta  ggtttcagg  atccactgg  gtcttggaa  360
gtatcctcc  aggataagg  aggactagt  tattcccca  acccctccc  cttgctacc  420
tttgctgct  ttctttaat  accctctcc  cctgtggcc  gtttctata  acttggcat  480
ctgtttgct  tctttgttt  gtcaatcac  tcctttctt  tctgcccaa  ccctggttg  540
aggtggcaa  ggctacatc  atgactttc  catgggccg  tttcttcga  atgccaagc  600
gtatgagat  ggggctggg  ccagcgagg  gaggcggct  gtcatcggc  gagccttca  660
tgcagactt  cactagtcc  gagaccctt  gcccccttt  cctgcacct  gtggccttt  720
ttgggaagt  gagatgtgg  ggctttccc  ccctgccca  agcaggccc  cctgcccag  780
tgctcttgt  agccctctg  cctctggat  aggttgagt  ctccacaac  gctcccaag  840
atcatgggc  tcgcagccg  gcctgtgcc  cggctagtg  tgtgtgatt  aaaatggac  900
cagcaggaa  catattgtc  ggggattgt  gggacaagt  ttggtgact  tgtgccctt  960
ctctctaac  tctgagccc  cctcccagg  taggcacct  ggggcatgc  ggtgcccac  1020
tcccagggt  ggcacctgg  ggcatgcag  tacccacct  tttctcttg  gtgaggctc  1080
ggcaaggag  tctctctgc  caagcacag  agaatcatg  cccctctcc  tgaattgga  1140
cttggtaca  gttaagtat  cctaatcct  aaatctgaa  cacttgtgg  tccaagcat  1200
ttggataag  caaattcaa  tttcagtct  ttttctggg  gaaaaaaat  ataaaccta  1260
cctagccag  cgtggtggc  catgcttgt  atcccagca  ttcaggagg  tgagatggg  1320
ggatcacct  aggtcagga  ttcaagacc  gcctggcca  catgtggaa  cctcgcctc  1380
actaaaaat  gaaaaaaat  agttgggca  ggtggtggg  acctgtaat  ccagctact  1440
caggaggct  aggcaggag  attacttga  cccaggagg  ggaggttgc  gtgagccga  1500
cttgtgcca  tgcactcca  cctgggcga  aagggcaaa  ctcttcaaa  aacaaaaca  1560
aacaaaaaa  ccctggccc  tgtttcttc  agtttctag  ggtatcagc  cctagcagc  1620
tatgaacac  tatgcttgc  tggccaggc  aggtggtgt  tgcctgtaa  cccagcact  1680
tgggaggcc  aggcaggtg  atcacttgc  gtcaggagt  caagaccag  ctgtccaac  1740
tggtgaaac  ccatctcta  taaaaatac  aaaattagc  aggggtggt  gtgcacgtc  1800
gtaatccca  ctactcagg  ggctgaggc  ggagaatca  ttgaacccg  gaggtggag  1860
ttgcaatga  ccaatatga  accgctgca  tccagcctg  gccatagag  gagactctg  1920
ctcaaaaaa  gaaagaaaa  taggctggg  acagtgact  atgcctgta  tcccaacac  1980
ttgggaggc  gaggcaggt  gatcacgag  tcaggagtt  aagaccagc  tggccaaga  2040
ggtaaaacc  cgtctctac  aaaaataca  aaattagcc  ggtgtggtg  caggctcct  2100
taatcccag  tacacagaa  actgaggca  gagaatcgc  tgaacgcag  aggcagagg  2160
tgcaggagc  gagatcgcg  cattgcact  cagcctggg  aacagagtg  gactctgtc  2220
caaaaaata  taataaaat  aatgaacac  catgctgct  agtccgcag  ggggcagag  2280
agaggacag  gtgcttttg  gtactgttg  aagactggc  cctcctgta  agcacctct  2340
agcccttgt  caccgccct  ccacgggca  catccagtc  tggccgtgt  accacccac  2400
gctgactgg  cagcaggca  aggccctac  cgagcaggc  ggagttggc  cgcatgact  2460
cagctgagg  tgcctgtgt  catttctcc  gatacccta  ggctaattt  gttataact  2520
cacagtggc  gctgccatt  tgtattaaa  atattgtga  ac  2562



<210> 2580
<211> 423
<212> PRT
<213> Homo sapiens
<308> P26440
<400> 2580

Met Ala Thr Ala Thr Arg Leu Leu Gly Trp Arg Val Ala Ser Trp Arg 
  1               5                  10                  15
Leu Arg Pro Pro Leu Ala Gly Phe Val Ser Gln Arg Ala His Ser Leu 
             20                  25                  30
Leu Pro Val Asp Asp Ala Ile Asn Gly Leu Ser Glu Glu Gln Arg Gln 
         35                  40                  45
Leu Arg Gln Thr Met Ala Lys Phe Leu Gln Glu His Leu Ala Pro Lys 
     50                  55                  60
Ala Gln Glu Ile Asp Arg Ser Asn Glu Phe Lys Asn Leu Arg Glu Phe 
 65                  70                  75                  80
Trp Lys Gln Leu Gly Asn Leu Gly Val Leu Gly Ile Thr Ala Pro Val 
                 85                  90                  95
Gln Tyr Gly Gly Ser Gly Leu Gly Tyr Leu Glu His Val Leu Val Met 
             100                105                110
Glu Glu Ile Ser Arg Ala Ser Gly Ala Val Gly Leu Ser Tyr Gly Ala 
         115                120                125
His Ser Asn Leu Cys Ile Asn Gln Leu Val Arg Asn Gly Asn Glu Ala 
     130                135                140
Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ile Ser Gly Glu Tyr Ile Gly 
 145                150                155                160
Ala Leu Ala Met Ser Glu Pro Asn Ala Gly Ser Asp Val Val Ser Met 
                 165                170                175
Lys Leu Lys Ala Glu Lys Lys Gly Asn His Tyr Ile Leu Asn Gly Asn 
             180                185                190
Lys Phe Trp Ile Thr Asn Gly Pro Asp Ala Asp Val Leu Ile Val Tyr 
         195                200                205
Ala Lys Thr Asp Leu Ala Ala Val Pro Ala Ser Arg Gly Ile Thr Ala 
     210                215                220
Phe Ile Val Glu Lys Gly Met Pro Gly Phe Ser Thr Ser Lys Lys Leu 
 225                230                235                240
Asp Lys Leu Gly Met Arg Gly Ser Asn Thr Cys Glu Leu Ile Phe Glu 
                 245                250                255
Asp Cys Lys Ile Pro Ala Ala Asn Ile Leu Gly His Glu Asn Lys Gly 
             260                265                270
Val Tyr Val Leu Met Ser Gly Leu Asp Leu Glu Arg Leu Val Leu Ala 
         275                280                285
Gly Gly Pro Leu Gly Leu Met Gln Ala Val Leu Asp His Thr Ile Pro 
     290                295                300
Tyr Leu His Val Arg Glu Ala Phe Gly Gln Lys Ile Gly His Phe Gln 
 305                310                315                320
Leu Met Gln Gly Lys Met Ala Asp Met Tyr Thr Arg Leu Met Ala Cys 
                 325                330                335
Arg Gln Tyr Val Tyr Asn Val Ala Lys Ala Cys Asp Glu Gly His Cys 
             340                345                350
Thr Ala Lys Asp Cys Ala Gly Val Ile Leu Tyr Ser Ala Glu Cys Ala 
         355                360                365
Thr Gln Val Ala Leu Asp Gly Ile Gln Cys Phe Gly Gly Asn Gly Tyr 
     370                375                380
Ile Asn Asp Phe Pro Met Gly Arg Phe Leu Arg Asp Ala Lys Leu Tyr 
 385                390                395                400
Glu Ile Gly Ala Gly Thr Ser Glu Val Arg Arg Leu Val Ile Gly Arg 
                 405                410                415
Ala Phe Asn Ala Asp Phe His 
             420



<210> 2581
<211> 2104
<212> DNA
<213> Rattus norvegicus
<308> J05031
<400> 2581

tggtataca  cggagatgg  gactgcagt  cggctgctg  ggcggcgag  ttccagttg  60
agactgcgg  ctttaccgt  gccccttgc  gtcccgcag  gggcccact  gatgttgcc  120
gtggatgat  atatcaacg  gctaaacga  gagcagaag  agcttcgtc  tacgatatc  180
aagttcgtt  aagagaacc  ggcccccaa  gcccaagag  ttgatcaaa  caatgactt  240
aagaacctg  gagagttct  gaagcagct  ggaagcctg  gagtcctgg  catcacagc  300
cccgttcag  atggtggct  tggcctggg  tacctagaa  atgtgttgg  gatggaaga  360
atatcccgg  cttcagcag  tgtggggct  agctatggc  ctcactcca  cctctgcat  420
aaccagatt  tccgcaatg  gaatgaggc  cagaaagag  aatatcttc  caagctcat  480
agtggtgag  tcatcggag  cctggccat  agtgagccc  acgctggct  tgacgttgt  540
tccatgagg  tgaaagcag  gaagaaagg  gatcactac  ttctgaatg  caacaagtt  600
tggatcacc  atggccctg  cgctgatgt  ctagttgtc  atgccaaga  agacttgac  660
gctgtgcct  cgtctcggg  catcacagc  ttcattgtg  aaaaggata  gcctggttt  720
agcacctcg  agaagctgg  caagctagg  atgaggggc  ccaacacct  tgagctagt  780
tttgaagac  gcaaggttc  tgctgctaa  atcctgagc  aagagagta  gggtgtcta  840
gtactgatg  gcgggctgg  cctagaacg  ctggtgctg  caggtggac  ccttgggat  900
atgcaggct  tcctggacc  caccattcc  tatttgcat  tgagggaag  ctttggcca  960
aagatcggc  aattccagc  gatgcaggg  aagatggct  acatgtaca  ccgcctcat  1020
gcatgtcga  agtatgtct  caatgtcgc  agggcctgt  acgagggcc  catcactgc  1080
aaggactgt  ctggtgtga  tctgtatac  gccgagtgt  ccacacaag  agccctgga  1140
ggcattcaa  gtttaggtg  aaatggcta  atcaatgac  tccccatgg  ccgctttct  1200
cgagatgcc  aactgtacg  gatcggagg  gggaccagt  aggtgaggc  gctagtcat  1260
ggcagagct  tcaacgcag  cttccgcta  cctggggcc  tcaccctgc  cccagcagc  1320
ggaggcctt  ggaagcaga  acgtggcag  cctctgact  ggctaagga  gctctgctg  1380
tcaactgcc  tcttgccag  cctctgctc  tcgtgaagt  ggattctcc  gccgtgcca  1440
ccagtcaat  aagaaagcc  aaaattcgg  ccccagctc  gaaaaaaaa  aaaaaaaaa  1500
agaaccaaa  gaaagccta  aatggctgc  aaaaggact  tggcttttc  ggggtttgc  1560
gggagggta  cagtgtctg  gcccttgtt  tctacttct  aatgtagta  cctcaccct  1620
tggggtagc  tatgacagg  acccaactc  ttttcgtgg  caagcctct  gcaggggag  1680
tctttctgt  gcaatgtaa  agaggcatt  cctctttca  ttgtcagat  cttgtggtc  1740
cttttcttg  ggaaaaggc  aaaaccatg  ccttcttag  tgtttcccc  agagctagc  1800
agacagttc  agaatgcct  tgtggcaga  ccatgaagg  cagagtcca  agtctagcc  1860
agacaactt  gagattggc  ccctggtgt  gctgagtgt  tacatcact  cgtcacagg  1920
tagcactgg  cctgctcac  tgaccttct  cagctgcct  actccggtg  cccagctta  1980
gttgcctgg  tcaactcca  ccttgctgt  tatgtatat  tctctagac  ccctgtggc  2040
aattttgtt  caaccacac  ggctctgct  ccattttgt  ttaaacata  tgcaaagta  2100
aaaa  2104



<210> 2582
<211> 424
<212> PRT
<213> Rattus norvegicus
<308> P12007
<400> 2582

Met Ala Thr Ala Val Arg Leu Leu Gly Arg Arg Val Ser Ser Trp Arg 
  1               5                  10                  15
Leu Arg Pro Leu Pro Ser Pro Leu Ala Val Pro Gln Arg Ala His Ser 
             20                  25                  30
Met Leu Pro Val Asp Asp Asp Ile Asn Gly Leu Asn Glu Glu Gln Lys 
         35                  40                  45
Gln Leu Arg His Thr Ile Ser Lys Phe Val Gln Glu Asn Leu Ala Pro 
     50                  55                  60
Lys Ala Gln Glu Ile Asp Gln Ser Asn Asp Phe Lys Asn Leu Arg Glu 
 65                  70                  75                  80
Phe Trp Lys Gln Leu Gly Ser Leu Gly Val Leu Gly Ile Thr Ala Pro 
                 85                  90                  95
Val Gln Tyr Gly Gly Ser Gly Leu Gly Tyr Leu Glu His Val Leu Val 
             100                105                110
Met Glu Glu Ile Ser Arg Ala Ser Ala Ala Val Gly Leu Ser Tyr Gly 
         115                120                125
Ala His Ser Asn Leu Cys Ile Asn Gln Ile Val Arg Asn Gly Asn Glu 
     130                135                140
Ala Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ile Ser Gly Glu Phe Ile 
 145                150                155                160
Gly Ala Leu Ala Met Ser Glu Pro Asn Ala Gly Ser Asp Val Val Ser 
                 165                170                175
Met Arg Leu Lys Ala Glu Lys Lys Gly Asp His Tyr Val Leu Asn Gly 
             180                185                190
Asn Lys Phe Trp Ile Thr Asn Gly Pro Asp Ala Asp Val Leu Val Val 
         195                200                205
Tyr Ala Lys Thr Asp Leu Thr Ala Val Pro Ala Ser Arg Gly Ile Thr 
     210                215                220
Ala Phe Ile Val Glu Lys Asp Met Pro Gly Phe Ser Thr Ser Lys Lys 
 225                230                235                240
Leu Asp Lys Leu Gly Met Arg Gly Ser Asn Thr Cys Glu Leu Val Phe 
                 245                250                255
Glu Asp Cys Lys Val Pro Ala Ala Asn Ile Leu Ser Gln Glu Ser Lys 
             260                265                270
Gly Val Tyr Val Leu Met Ser Gly Leu Asp Leu Glu Arg Leu Val Leu 
         275                280                285
Ala Gly Gly Pro Leu Gly Ile Met Gln Ala Val Leu Asp His Thr Ile 
     290                295                300
Pro Tyr Leu His Val Arg Glu Ala Phe Gly Gln Lys Ile Gly Gln Phe 
 305                310                315                320
Gln Leu Met Gln Gly Lys Met Ala Asp Met Tyr Thr Arg Leu Met Ala 
                 325                330                335
Cys Arg Gln Tyr Val Tyr Asn Val Ala Arg Ala Cys Asp Glu Gly His 
             340                345                350
Ile Thr Ala Lys Asp Cys Ala Gly Val Ile Leu Tyr Thr Ala Glu Cys 
         355                360                365
Ala Thr Gln Val Ala Leu Asp Gly Ile Gln Cys Leu Gly Gly Asn Gly 
     370                375                380
Tyr Ile Asn Asp Phe Pro Met Gly Arg Phe Leu Arg Asp Ala Lys Leu 
 385                390                395                400
Tyr Glu Ile Gly Gly Gly Thr Ser Glu Val Arg Arg Leu Val Ile Gly 
                 405                410                415
Arg Ala Phe Asn Ala Asp Phe Arg 
             420



<210> 2583
<211> 2562
<212> DNA
<213> Homo sapiens
<308> AK022777
<400> 2583

gttgtgcca  gctgctctg  catgtttgg  acgtgaatc  tccctttgt  cagcctatc  60
atgctatgt  ggctacctg  ccgttagta  tcacctagg  tatccaatc  gctgtcctg  120
tatcagagt  cctgtgttc  agtaactct  attttgctc  gtggcccca  attgcaaga  180
tagtgatgc  ggcatgtca  aatagttct  ttttagtat  tgttattat  gttgatctg  240
tactatgcc  agctcataa  ttaaacttt  tcataagta  gtatgtata  ggaaaaaaa  300
aacatatat  tgggtttcg  ttctatcta  ggtttcagg  atccactgg  gtcttggaa  360
gtatcctcc  aggataagg  aggactagt  tattcccca  acccctccc  cttgctacc  420
tttgctgct  ttctttaat  accctctcc  cctgtggcc  gtttctata  acttggcat  480
ctgtttgct  tctttgttt  gtcaatcac  tcctttctt  tctgcccaa  ccctggttg  540
aggtggcaa  ggctacatc  atgactttc  catgggccg  tttcttcga  atgccaagc  600
gtatgagat  ggggctggg  ccagcgagg  gaggcggct  gtcatcggc  gagccttca  660
tgcagactt  cactagtcc  gagaccctt  gcccccttt  cctgcacct  gtggccttt  720
ttgggaagt  gagatgtgg  ggctttccc  ccctgccca  agcaggccc  cctgcccag  780
tgctcttgt  agccctctg  cctctggat  aggttgagt  ctccacaac  gctcccaag  840
atcatgggc  tcgcagccg  gcctgtgcc  cggctagtg  tgtgtgatt  aaaatggac  900
cagcaggaa  catattgtc  ggggattgt  gggacaagt  ttggtgact  tgtgccctt  960
ctctctaac  tctgagccc  cctcccagg  taggcacct  ggggcatgc  ggtgcccac  1020
tcccagggt  ggcacctgg  ggcatgcag  tacccacct  tttctcttg  gtgaggctc  1080
ggcaaggag  tctctctgc  caagcacag  agaatcatg  cccctctcc  tgaattgga  1140
cttggtaca  gttaagtat  cctaatcct  aaatctgaa  cacttgtgg  tccaagcat  1200
ttggataag  caaattcaa  tttcagtct  ttttctggg  gaaaaaaat  ataaaccta  1260
cctagccag  cgtggtggc  catgcttgt  atcccagca  ttcaggagg  tgagatggg  1320
ggatcacct  aggtcagga  ttcaagacc  gcctggcca  catgtggaa  cctcgcctc  1380
actaaaaat  gaaaaaaat  agttgggca  ggtggtggg  acctgtaat  ccagctact  1440
caggaggct  aggcaggag  attacttga  cccaggagg  ggaggttgc  gtgagccga  1500
cttgtgcca  tgcactcca  cctgggcga  aagggcaaa  ctcttcaaa  aacaaaaca  1560
aacaaaaaa  ccctggccc  tgtttcttc  agtttctag  ggtatcagc  cctagcagc  1620
tatgaacac  tatgcttgc  tggccaggc  aggtggtgt  tgcctgtaa  cccagcact  1680
tgggaggcc  aggcaggtg  atcacttgc  gtcaggagt  caagaccag  ctgtccaac  1740
tggtgaaac  ccatctcta  taaaaatac  aaaattagc  aggggtggt  gtgcacgtc  1800
gtaatccca  ctactcagg  ggctgaggc  ggagaatca  ttgaacccg  gaggtggag  1860
ttgcaatga  ccaatatga  accgctgca  tccagcctg  gccatagag  gagactctg  1920
ctcaaaaaa  gaaagaaaa  taggctggg  acagtgact  atgcctgta  tcccaacac  1980
ttgggaggc  gaggcaggt  gatcacgag  tcaggagtt  aagaccagc  tggccaaga  2040
ggtaaaacc  cgtctctac  aaaaataca  aaattagcc  ggtgtggtg  caggctcct  2100
taatcccag  tacacagaa  actgaggca  gagaatcgc  tgaacgcag  aggcagagg  2160
tgcaggagc  gagatcgcg  cattgcact  cagcctggg  aacagagtg  gactctgtc  2220
caaaaaata  taataaaat  aatgaacac  catgctgct  agtccgcag  ggggcagag  2280
agaggacag  gtgcttttg  gtactgttg  aagactggc  cctcctgta  agcacctct  2340
agcccttgt  caccgccct  ccacgggca  catccagtc  tggccgtgt  accacccac  2400
gctgactgg  cagcaggca  aggccctac  cgagcaggc  ggagttggc  cgcatgact  2460
cagctgagg  tgcctgtgt  catttctcc  gatacccta  ggctaattt  gttataact  2520
cacagtggc  gctgccatt  tgtattaaa  atattgtga  ac  2562



<210> 2584
<211> 423
<212> PRT
<213> Homo sapiens
<308> P26440
<400> 2584

Met Ala Thr Ala Thr Arg Leu Leu Gly Trp Arg Val Ala Ser Trp Arg 
  1               5                  10                  15
Leu Arg Pro Pro Leu Ala Gly Phe Val Ser Gln Arg Ala His Ser Leu 
             20                  25                  30
Leu Pro Val Asp Asp Ala Ile Asn Gly Leu Ser Glu Glu Gln Arg Gln 
         35                  40                  45
Leu Arg Gln Thr Met Ala Lys Phe Leu Gln Glu His Leu Ala Pro Lys 
     50                  55                  60
Ala Gln Glu Ile Asp Arg Ser Asn Glu Phe Lys Asn Leu Arg Glu Phe 
 65                  70                  75                  80
Trp Lys Gln Leu Gly Asn Leu Gly Val Leu Gly Ile Thr Ala Pro Val 
                 85                  90                  95
Gln Tyr Gly Gly Ser Gly Leu Gly Tyr Leu Glu His Val Leu Val Met 
             100                105                110
Glu Glu Ile Ser Arg Ala Ser Gly Ala Val Gly Leu Ser Tyr Gly Ala 
         115                120                125
His Ser Asn Leu Cys Ile Asn Gln Leu Val Arg Asn Gly Asn Glu Ala 
     130                135                140
Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ile Ser Gly Glu Tyr Ile Gly 
 145                150                155                160
Ala Leu Ala Met Ser Glu Pro Asn Ala Gly Ser Asp Val Val Ser Met 
                 165                170                175
Lys Leu Lys Ala Glu Lys Lys Gly Asn His Tyr Ile Leu Asn Gly Asn 
             180                185                190
Lys Phe Trp Ile Thr Asn Gly Pro Asp Ala Asp Val Leu Ile Val Tyr 
         195                200                205
Ala Lys Thr Asp Leu Ala Ala Val Pro Ala Ser Arg Gly Ile Thr Ala 
     210                215                220
Phe Ile Val Glu Lys Gly Met Pro Gly Phe Ser Thr Ser Lys Lys Leu 
 225                230                235                240
Asp Lys Leu Gly Met Arg Gly Ser Asn Thr Cys Glu Leu Ile Phe Glu 
                 245                250                255
Asp Cys Lys Ile Pro Ala Ala Asn Ile Leu Gly His Glu Asn Lys Gly 
             260                265                270
Val Tyr Val Leu Met Ser Gly Leu Asp Leu Glu Arg Leu Val Leu Ala 
         275                280                285
Gly Gly Pro Leu Gly Leu Met Gln Ala Val Leu Asp His Thr Ile Pro 
     290                295                300
Tyr Leu His Val Arg Glu Ala Phe Gly Gln Lys Ile Gly His Phe Gln 
 305                310                315                320
Leu Met Gln Gly Lys Met Ala Asp Met Tyr Thr Arg Leu Met Ala Cys 
                 325                330                335
Arg Gln Tyr Val Tyr Asn Val Ala Lys Ala Cys Asp Glu Gly His Cys 
             340                345                350
Thr Ala Lys Asp Cys Ala Gly Val Ile Leu Tyr Ser Ala Glu Cys Ala 
         355                360                365
Thr Gln Val Ala Leu Asp Gly Ile Gln Cys Phe Gly Gly Asn Gly Tyr 
     370                375                380
Ile Asn Asp Phe Pro Met Gly Arg Phe Leu Arg Asp Ala Lys Leu Tyr 
 385                390                395                400
Glu Ile Gly Ala Gly Thr Ser Glu Val Arg Arg Leu Val Ile Gly Arg 
                 405                410                415
Ala Phe Asn Ala Asp Phe His 
             420



<210> 2585
<211> 2470
<212> DNA
<213> Rattus norvegicus
<308> J05035
<400> 2585

acctcagct  tggagttgg  tgagctgtg  ctgctcgac  tgctggtct  cttggaagg  60
ttcatggcc  tcgtgtcca  tgtggggct  cggtcggtt  gctctccgt  cggccgcta  120
tcgccgcag  ggcccggca  ccgagtgcc  gcgcgacct  cctggttca  acaggagct  180
ccctcgatg  cctggccgc  gtacgagta  attcgtcct  cagccgcgc  actgggcaa  240
ctgcctaac  gcgtcctgc  ggctatgtt  ctgatccac  acgtgcaaa  gacgctggt  300
ttcccggtt  tgatcaggg  agggaagcc  accctcctg  tcacctttg  cttggcctt  360
ctgttctgc  ccttcaacg  ctatgtaca  agcagatac  tgagccagt  tgcggttta  420
gctgaagac  gggtgaccc  tccctgttt  ctgacaggc  ttgccctgt  gttagtggg  480
atggtgata  atatccact  agaccacat  ctgaggaat  tgagaaaac  aggggaaac  540
ggatacaag  tacccaggg  aggcctgtt  gaatacgta  ctgcagcca  ctattttgg  600
gagctcgtg  agtggtgtg  ctttgcact  gccagctgg  ccctccagg  tgtagtgtt  660
gcactgttc  cactcagca  actgctcac  agagcgaag  agcaccatc  gtggtacca  720
gagaagttt  aagattacc  caagtcaag  aaaatactg  ttccatttg  gctttagtg  780
tctgttagc  ctgttgcct  ccatgagct  agtctgtct  tctccctgg  gactttgct  840
tgagcactt  cgaatgaat  gttttcctt  attctcctg  agccccttt  tcaggaaag  900
ctgggggtg  gggggtgtc  tcccctggt  aaggacaaa  ccaatgata  actaatcca  960
cacatgcag  taggggcta  actgcctgc  ggatccgaa  caggtagcc  tgagtcatt  1020
tggcgctct  tgacttcag  aatcagcag  ccttacaat  ctgcaagat  ccacccaag  1080
cagcagcag  cacgggcct  cttcactga  gtgtgttct  cctgctcag  ccctgccac  1140
gaggcctgg  ggtgtggga  tgtggccta  gcacagtct  ccatccttg  ccgcagacc  1200
cttggaccc  cccccactc  ctccagaca  tggtaagag  agccttcct  caacatgtc  1260
tgtcctcag  aggtgagac  gcagagtgc  tccattcac  cgatgaccc  atttttgct  1320
ttcctttgg  ctagaattc  ttaaggtcc  taaaaacaa  acaaaactt  ttcttaata  1380
tacaaaaca  aatatcaaa  caaaatttg  tattttgaa  gcacccaag  accaatcat  1440
tcacacaaa  aaagctcag  gctagcctg  gctgtgtag  gagaccctg  ttgggaaaa  1500
aaaaatgaa  ataacaacc  gctaactgt  caaagaagt  accgcagta  taaaagacg  1560
cgcccacac  ggcaccagc  tgggagaaa  atgtgcgcc  gggattgta  acccactgt  1620
gctctgggc  ggctgaggc  cactggtga  gagccattc  caccggacc  atgcacact  1680
cctcggggc  gcgtctgca  tcacctctc  cccgctgcc  ccacagcta  agaacagaa  1740
ggatagaac  gtgtgctct  aacccagtg  agatgctgc  tgaagacct  caggcacac  1800
tgatggcgt  cacggtgcc  accactcgc  tgactcgga  catctctgt  tgcccgctg  1860
cacctctgt  tgccctttc  agctggctt  cccatcagg  cttcctcag  tcttctgct  1920
tcagacaga  actattctc  gttcctctg  ttcgcagaa  gtctagatt  gacccagaa  1980
acttcatga  acagctact  cattttaac  aagagcagt  tttaatggg  aactaccct  2040
caatccttt  ccctcccct  ttctggcca  gtaactgct  gaaaaccta  agcactaaa  2100
attgtaggt  tcctctcaa  acctcaggc  tgtctggtg  gttctgaaa  gtttgtgtg  2160
aaggagata  tcagctgag  ccctgggaa  gtttgctgt  aacttgacc  cccttggag  2220
gcatggtgc  agataaact  ggaacctag  actccaggt  gctaggcgg  tgccctgac  2280
ctaagccac  tcacacatt  gctctgtga  gcctctttc  ttatgaagg  ccaagctgc  2340
cacatacta  gtgagatta  tttaagagg  atcctgtcc  aacactgta  acttcattc  2400
ctacaactc  acttacttg  atgaaccat  attgttaag  aaattaata  actacattt  2460
taagtaaaaa  2470



<210> 2586
<211> 259
<212> PRT
<213> Rattus norvegicus
<308> P24008
<400> 2586

Met Val Pro Leu Met Glu Leu Asp Glu Leu Cys Leu Leu Asp Met Leu 
  1               5                  10                  15
Val Tyr Leu Glu Gly Phe Met Ala Phe Val Ser Ile Val Gly Leu Arg 
             20                  25                  30
Ser Val Gly Ser Pro Tyr Gly Arg Tyr Ser Pro Gln Trp Pro Gly Ile 
         35                  40                  45
Arg Val Pro Ala Arg Pro Ala Trp Phe Ile Gln Glu Leu Pro Ser Met 
     50                  55                  60
Ala Trp Pro Leu Tyr Glu Tyr Ile Arg Pro Ala Ala Ala Arg Leu Gly 
 65                  70                  75                  80
Asn Leu Pro Asn Arg Val Leu Leu Ala Met Phe Leu Ile His Tyr Val 
                 85                  90                  95
Gln Arg Thr Leu Val Phe Pro Val Leu Ile Arg Gly Gly Lys Pro Thr 
             100                105                110
Leu Leu Val Thr Phe Val Leu Ala Phe Leu Phe Cys Thr Phe Asn Gly 
         115                120                125
Tyr Val Gln Ser Arg Tyr Leu Ser Gln Phe Ala Val Tyr Ala Glu Asp 
     130                135                140
Trp Val Thr His Pro Cys Phe Leu Thr Gly Phe Ala Leu Trp Leu Val 
 145                150                155                160
Gly Met Val Ile Asn Ile His Ser Asp His Ile Leu Arg Asn Leu Arg 
                 165                170                175
Lys Pro Gly Glu Thr Gly Tyr Lys Ile Pro Arg Gly Gly Leu Phe Glu 
             180                185                190
Tyr Val Ser Ala Ala Asn Tyr Phe Gly Glu Leu Val Glu Trp Cys Gly 
         195                200                205
Phe Ala Leu Ala Ser Trp Ser Leu Gln Gly Val Val Phe Ala Leu Phe 
     210                215                220
Thr Leu Ser Thr Leu Leu Thr Arg Ala Lys Gln His His Gln Trp Tyr 
 225                230                235                240
His Glu Lys Phe Glu Asp Tyr Pro Lys Ser Arg Lys Ile Leu Ile Pro 
                 245                250                255
Phe Val Leu 
             260



<210> 2587
<211> 2222
<212> DNA
<213> Homo sapiens
<308> NM_001047
<400> 2587

gagtcccgg  agtgcggga  tccggtagc  gcccctccg  tagccgccc  tcctccccc  60
gcgccgccg  cctatatgt  gcccgccgc  gcctctggg  catggagca  gctgcccag  120
cctggcgat  gcaacggcg  cgggggtgg  ggaggagcg  ctgctggcc  cgctcgcct  180
cctgcagtg  gccgtgggc  gcgcggtct  cgcgcggaa  cgtcagacg  actcagtgt  240
cggccgcca  gcgctgccc  gccacaggc  ccgagtgcc  gcgcgggcc  cctgggtgg  300
gcaggagct  ccctcgctg  ccctgccgc  ctaccagta  gccagcgag  ccgccccgc  360
tctccgcag  gcgcccaac  gcatcctcc  ggccatgtt  ctcgtccac  acgggcatc  420
gtgcttaat  tacccgttt  tgatgcgag  aggaaagcc  atgccactg  tggcatgta  480
aatggcgat  atgttctgt  cctgtaacg  ctatttgca  agcagatac  tgagccatt  540
tgcagtgta  gctgatgac  gggtaacag  tccccgttt  ctaataggt  ttggcttgt  600
gttaacagg  atgttgata  acatccatt  agatcatat  ctaaggaat  tcagaaaac  660
aggagatac  ggatacaaa  taccaaggg  aggcttatt  gaatacgta  ctgcagcca  720
ctattttgg  gaaatcatg  agtggtgtg  ctatgccct  gccagctgg  ctgtccaag  780
cgcggcttt  gctttcttc  cgttttgtt  tttatctgg  agagcaaaa  agcatcatg  840
gtggtacct  cggaaattt  aagagtatc  aaagttcag  aaaattata  ttccatttt  900
gttttaagt  cgtttttca  gaaattatc  tcaacttga  gctttccaa  ggcgcttct  960
tatggactt  gtaaataag  tatatcttt  taattttcc  gctacttta  cattttcaa  1020
atgtcctct  ggaattttt  ttctagtaa  tttgcaatc  acctaataa  tacctaaat  1080
cgctgaaat  gaggttgaa  atcctactg  gtaacaggt  agaatttca  gctctgggt  1140
ataactgct  atatttttt  taatttcaa  tttacctct  ttggctatg  cttgccaag  1200
gtgtatgag  ctagacttt  caactgtct  tgatggcat  ttcagaaca  taaatgtca  1260
aatcccttc  atagccccc  acagtgatc  cttcaaggt  aactgcagt  ttgcttccc  1320
ccccctata  ggctggaat  tgtctagga  ccctctctc  gaggccata  aggctgggg  1380
tagccattg  gcagtcatg  cccggggga  acttgccaa  cttcgtgtc  ggtgctgtg  1440
ataagtgga  aacttgggg  tagaggagg  agctcctcg  ggcccttcc  aggtgaggc  1500
aaggcatct  gacttgttc  agcccagcc  accgggtga  atcaccggg  agggagggg  1560
gctggtggt  gttcatacg  agtaagctg  tctgcctgt  tgagtggct  ctgggccct  1620
aacaggcac  tttaggcca  gggtcactc  ccgtgagcc  tcaatgtgc  ctggtctga  1680
atggtttct  tctgtcttc  agtctagac  tagtttttt  gttctgttc  ccacgtatg  1740
atatagtag  gattgttgt  tgtgaaatt  ctcttttgt  gattttgag  tttcccttg  1800
agtgtaaag  atgatcact  tctgtaaca  taacaagac  actttttaa  atttatcct  1860
tttgttctt  gttgattga  acataataa  tgttaaaat  ctctacagc  ttctttttc  1920
tccatagct  atcttcctt  taatagttt  tgctttctg  tttgctgtt  ttgctttgc  1980
aagctttcc  ctcatagcc  gtacctgtt  tcaatataa  ataatcttc  tgttgaatg  2040
ttcatgact  gaattctac  ttgataaaa  cattgccat  ctgcttttt  tcttgatga  2100
ttcatctgg  attgctttg  cttatcatc  catctggag  ttttaaatg  catttgttt  2160
agttgtctt  aacaacata  taaatagac  ttgccattt  aaaaaaaaa  aaaaaaaaa  2220
aa  2222



<210> 2588
<211> 259
<212> PRT
<213> Homo sapiens
<308> P18405
<400> 2588

Met Ala Thr Ala Thr Gly Val Ala Glu Glu Arg Leu Leu Ala Ala Leu 
  1               5                  10                  15
Ala Tyr Leu Gln Cys Ala Val Gly Cys Ala Val Phe Ala Arg Asn Arg 
             20                  25                  30
Gln Thr Asn Ser Val Tyr Gly Arg His Ala Leu Pro Ser His Arg Leu 
         35                  40                  45
Arg Val Pro Ala Arg Ala Ala Trp Val Val Gln Glu Leu Pro Ser Leu 
     50                  55                  60
Ala Leu Pro Leu Tyr Gln Tyr Ala Ser Glu Ser Ala Pro Arg Leu Arg 
 65                  70                  75                  80
Ser Ala Pro Asn Cys Ile Leu Leu Ala Met Phe Leu Val His Tyr Gly 
                 85                  90                  95
His Arg Cys Leu Ile Tyr Pro Phe Leu Met Arg Gly Gly Lys Pro Met 
             100                105                110
Pro Leu Leu Ala Cys Thr Met Ala Ile Met Phe Cys Thr Cys Asn Gly 
         115                120                125
Tyr Leu Gln Ser Arg Tyr Leu Ser His Cys Ala Val Tyr Ala Asp Asp 
     130                135                140
Trp Val Thr Asp Pro Arg Phe Leu Ile Gly Phe Gly Leu Trp Leu Thr 
 145                150                155                160
Gly Met Leu Ile Asn Ile His Ser Asp His Ile Leu Arg Asn Leu Arg 
                 165                170                175
Lys Pro Gly Asp Thr Gly Tyr Lys Ile Pro Arg Gly Gly Leu Phe Glu 
             180                185                190
Tyr Val Thr Ala Ala Asn Tyr Phe Gly Glu Ile Met Glu Trp Cys Gly 
         195                200                205
Tyr Ala Leu Ala Ser Trp Ser Val Gln Gly Ala Ala Phe Ala Phe Phe 
     210                215                220
Thr Phe Cys Phe Leu Ser Gly Arg Ala Lys Glu His His Glu Trp Tyr 
 225                230                235                240
Leu Arg Lys Phe Glu Glu Tyr Pro Lys Phe Arg Lys Ile Ile Ile Pro 
                 245                250                255
Phe Leu Phe 
             260



<210> 2589
<211> 2470
<212> DNA
<213> Rattus norvegicus
<308> J05035
<400> 2589

acctcagct  tggagttgg  tgagctgtg  ctgctcgac  tgctggtct  cttggaagg  60
ttcatggcc  tcgtgtcca  tgtggggct  cggtcggtt  gctctccgt  cggccgcta  120
tcgccgcag  ggcccggca  ccgagtgcc  gcgcgacct  cctggttca  acaggagct  180
ccctcgatg  cctggccgc  gtacgagta  attcgtcct  cagccgcgc  actgggcaa  240
ctgcctaac  gcgtcctgc  ggctatgtt  ctgatccac  acgtgcaaa  gacgctggt  300
ttcccggtt  tgatcaggg  agggaagcc  accctcctg  tcacctttg  cttggcctt  360
ctgttctgc  ccttcaacg  ctatgtaca  agcagatac  tgagccagt  tgcggttta  420
gctgaagac  gggtgaccc  tccctgttt  ctgacaggc  ttgccctgt  gttagtggg  480
atggtgata  atatccact  agaccacat  ctgaggaat  tgagaaaac  aggggaaac  540
ggatacaag  tacccaggg  aggcctgtt  gaatacgta  ctgcagcca  ctattttgg  600
gagctcgtg  agtggtgtg  ctttgcact  gccagctgg  ccctccagg  tgtagtgtt  660
gcactgttc  cactcagca  actgctcac  agagcgaag  agcaccatc  gtggtacca  720
gagaagttt  aagattacc  caagtcaag  aaaatactg  ttccatttg  gctttagtg  780
tctgttagc  ctgttgcct  ccatgagct  agtctgtct  tctccctgg  gactttgct  840
tgagcactt  cgaatgaat  gttttcctt  attctcctg  agccccttt  tcaggaaag  900
ctgggggtg  gggggtgtc  tcccctggt  aaggacaaa  ccaatgata  actaatcca  960
cacatgcag  taggggcta  actgcctgc  ggatccgaa  caggtagcc  tgagtcatt  1020
tggcgctct  tgacttcag  aatcagcag  ccttacaat  ctgcaagat  ccacccaag  1080
cagcagcag  cacgggcct  cttcactga  gtgtgttct  cctgctcag  ccctgccac  1140
gaggcctgg  ggtgtggga  tgtggccta  gcacagtct  ccatccttg  ccgcagacc  1200
cttggaccc  cccccactc  ctccagaca  tggtaagag  agccttcct  caacatgtc  1260
tgtcctcag  aggtgagac  gcagagtgc  tccattcac  cgatgaccc  atttttgct  1320
ttcctttgg  ctagaattc  ttaaggtcc  taaaaacaa  acaaaactt  ttcttaata  1380
tacaaaaca  aatatcaaa  caaaatttg  tattttgaa  gcacccaag  accaatcat  1440
tcacacaaa  aaagctcag  gctagcctg  gctgtgtag  gagaccctg  ttgggaaaa  1500
aaaaatgaa  ataacaacc  gctaactgt  caaagaagt  accgcagta  taaaagacg  1560
cgcccacac  ggcaccagc  tgggagaaa  atgtgcgcc  gggattgta  acccactgt  1620
gctctgggc  ggctgaggc  cactggtga  gagccattc  caccggacc  atgcacact  1680
cctcggggc  gcgtctgca  tcacctctc  cccgctgcc  ccacagcta  agaacagaa  1740
ggatagaac  gtgtgctct  aacccagtg  agatgctgc  tgaagacct  caggcacac  1800
tgatggcgt  cacggtgcc  accactcgc  tgactcgga  catctctgt  tgcccgctg  1860
cacctctgt  tgccctttc  agctggctt  cccatcagg  cttcctcag  tcttctgct  1920
tcagacaga  actattctc  gttcctctg  ttcgcagaa  gtctagatt  gacccagaa  1980
acttcatga  acagctact  cattttaac  aagagcagt  tttaatggg  aactaccct  2040
caatccttt  ccctcccct  ttctggcca  gtaactgct  gaaaaccta  agcactaaa  2100
attgtaggt  tcctctcaa  acctcaggc  tgtctggtg  gttctgaaa  gtttgtgtg  2160
aaggagata  tcagctgag  ccctgggaa  gtttgctgt  aacttgacc  cccttggag  2220
gcatggtgc  agataaact  ggaacctag  actccaggt  gctaggcgg  tgccctgac  2280
ctaagccac  tcacacatt  gctctgtga  gcctctttc  ttatgaagg  ccaagctgc  2340
cacatacta  gtgagatta  tttaagagg  atcctgtcc  aacactgta  acttcattc  2400
ctacaactc  acttacttg  atgaaccat  attgttaag  aaattaata  actacattt  2460
taagtaaaaa  2470



<210> 2590
<211> 259
<212> PRT
<213> Rattus norvegicus
<308> P24008
<400> 2590

Met Val Pro Leu Met Glu Leu Asp Glu Leu Cys Leu Leu Asp Met Leu 
  1               5                  10                  15
Val Tyr Leu Glu Gly Phe Met Ala Phe Val Ser Ile Val Gly Leu Arg 
             20                  25                  30
Ser Val Gly Ser Pro Tyr Gly Arg Tyr Ser Pro Gln Trp Pro Gly Ile 
         35                  40                  45
Arg Val Pro Ala Arg Pro Ala Trp Phe Ile Gln Glu Leu Pro Ser Met 
     50                  55                  60
Ala Trp Pro Leu Tyr Glu Tyr Ile Arg Pro Ala Ala Ala Arg Leu Gly 
 65                  70                  75                  80
Asn Leu Pro Asn Arg Val Leu Leu Ala Met Phe Leu Ile His Tyr Val 
                 85                  90                  95
Gln Arg Thr Leu Val Phe Pro Val Leu Ile Arg Gly Gly Lys Pro Thr 
             100                105                110
Leu Leu Val Thr Phe Val Leu Ala Phe Leu Phe Cys Thr Phe Asn Gly 
         115                120                125
Tyr Val Gln Ser Arg Tyr Leu Ser Gln Phe Ala Val Tyr Ala Glu Asp 
     130                135                140
Trp Val Thr His Pro Cys Phe Leu Thr Gly Phe Ala Leu Trp Leu Val 
 145                150                155                160
Gly Met Val Ile Asn Ile His Ser Asp His Ile Leu Arg Asn Leu Arg 
                 165                170                175
Lys Pro Gly Glu Thr Gly Tyr Lys Ile Pro Arg Gly Gly Leu Phe Glu 
             180                185                190
Tyr Val Ser Ala Ala Asn Tyr Phe Gly Glu Leu Val Glu Trp Cys Gly 
         195                200                205
Phe Ala Leu Ala Ser Trp Ser Leu Gln Gly Val Val Phe Ala Leu Phe 
     210                215                220
Thr Leu Ser Thr Leu Leu Thr Arg Ala Lys Gln His His Gln Trp Tyr 
 225                230                235                240
His Glu Lys Phe Glu Asp Tyr Pro Lys Ser Arg Lys Ile Leu Ile Pro 
                 245                250                255
Phe Val Leu 
             260



<210> 2591
<211> 2222
<212> DNA
<213> Homo sapiens
<308> NM_001047
<400> 2591

gagtcccgg  agtgcggga  tccggtagc  gcccctccg  tagccgccc  tcctccccc  60
gcgccgccg  cctatatgt  gcccgccgc  gcctctggg  catggagca  gctgcccag  120
cctggcgat  gcaacggcg  cgggggtgg  ggaggagcg  ctgctggcc  cgctcgcct  180
cctgcagtg  gccgtgggc  gcgcggtct  cgcgcggaa  cgtcagacg  actcagtgt  240
cggccgcca  gcgctgccc  gccacaggc  ccgagtgcc  gcgcgggcc  cctgggtgg  300
gcaggagct  ccctcgctg  ccctgccgc  ctaccagta  gccagcgag  ccgccccgc  360
tctccgcag  gcgcccaac  gcatcctcc  ggccatgtt  ctcgtccac  acgggcatc  420
gtgcttaat  tacccgttt  tgatgcgag  aggaaagcc  atgccactg  tggcatgta  480
aatggcgat  atgttctgt  cctgtaacg  ctatttgca  agcagatac  tgagccatt  540
tgcagtgta  gctgatgac  gggtaacag  tccccgttt  ctaataggt  ttggcttgt  600
gttaacagg  atgttgata  acatccatt  agatcatat  ctaaggaat  tcagaaaac  660
aggagatac  ggatacaaa  taccaaggg  aggcttatt  gaatacgta  ctgcagcca  720
ctattttgg  gaaatcatg  agtggtgtg  ctatgccct  gccagctgg  ctgtccaag  780
cgcggcttt  gctttcttc  cgttttgtt  tttatctgg  agagcaaaa  agcatcatg  840
gtggtacct  cggaaattt  aagagtatc  aaagttcag  aaaattata  ttccatttt  900
gttttaagt  cgtttttca  gaaattatc  tcaacttga  gctttccaa  ggcgcttct  960
tatggactt  gtaaataag  tatatcttt  taattttcc  gctacttta  cattttcaa  1020
atgtcctct  ggaattttt  ttctagtaa  tttgcaatc  acctaataa  tacctaaat  1080
cgctgaaat  gaggttgaa  atcctactg  gtaacaggt  agaatttca  gctctgggt  1140
ataactgct  atatttttt  taatttcaa  tttacctct  ttggctatg  cttgccaag  1200
gtgtatgag  ctagacttt  caactgtct  tgatggcat  ttcagaaca  taaatgtca  1260
aatcccttc  atagccccc  acagtgatc  cttcaaggt  aactgcagt  ttgcttccc  1320
ccccctata  ggctggaat  tgtctagga  ccctctctc  gaggccata  aggctgggg  1380
tagccattg  gcagtcatg  cccggggga  acttgccaa  cttcgtgtc  ggtgctgtg  1440
ataagtgga  aacttgggg  tagaggagg  agctcctcg  ggcccttcc  aggtgaggc  1500
aaggcatct  gacttgttc  agcccagcc  accgggtga  atcaccggg  agggagggg  1560
gctggtggt  gttcatacg  agtaagctg  tctgcctgt  tgagtggct  ctgggccct  1620
aacaggcac  tttaggcca  gggtcactc  ccgtgagcc  tcaatgtgc  ctggtctga  1680
atggtttct  tctgtcttc  agtctagac  tagtttttt  gttctgttc  ccacgtatg  1740
atatagtag  gattgttgt  tgtgaaatt  ctcttttgt  gattttgag  tttcccttg  1800
agtgtaaag  atgatcact  tctgtaaca  taacaagac  actttttaa  atttatcct  1860
tttgttctt  gttgattga  acataataa  tgttaaaat  ctctacagc  ttctttttc  1920
tccatagct  atcttcctt  taatagttt  tgctttctg  tttgctgtt  ttgctttgc  1980
aagctttcc  ctcatagcc  gtacctgtt  tcaatataa  ataatcttc  tgttgaatg  2040
ttcatgact  gaattctac  ttgataaaa  cattgccat  ctgcttttt  tcttgatga  2100
ttcatctgg  attgctttg  cttatcatc  catctggag  ttttaaatg  catttgttt  2160
agttgtctt  aacaacata  taaatagac  ttgccattt  aaaaaaaaa  aaaaaaaaa  2220
aa  2222



<210> 2592
<211> 259
<212> PRT
<213> Homo sapiens
<308> P18405
<400> 2592

Met Ala Thr Ala Thr Gly Val Ala Glu Glu Arg Leu Leu Ala Ala Leu 
  1               5                  10                  15
Ala Tyr Leu Gln Cys Ala Val Gly Cys Ala Val Phe Ala Arg Asn Arg 
             20                  25                  30
Gln Thr Asn Ser Val Tyr Gly Arg His Ala Leu Pro Ser His Arg Leu 
         35                  40                  45
Arg Val Pro Ala Arg Ala Ala Trp Val Val Gln Glu Leu Pro Ser Leu 
     50                  55                  60
Ala Leu Pro Leu Tyr Gln Tyr Ala Ser Glu Ser Ala Pro Arg Leu Arg 
 65                  70                  75                  80
Ser Ala Pro Asn Cys Ile Leu Leu Ala Met Phe Leu Val His Tyr Gly 
                 85                  90                  95
His Arg Cys Leu Ile Tyr Pro Phe Leu Met Arg Gly Gly Lys Pro Met 
             100                105                110
Pro Leu Leu Ala Cys Thr Met Ala Ile Met Phe Cys Thr Cys Asn Gly 
         115                120                125
Tyr Leu Gln Ser Arg Tyr Leu Ser His Cys Ala Val Tyr Ala Asp Asp 
     130                135                140
Trp Val Thr Asp Pro Arg Phe Leu Ile Gly Phe Gly Leu Trp Leu Thr 
 145                150                155                160
Gly Met Leu Ile Asn Ile His Ser Asp His Ile Leu Arg Asn Leu Arg 
                 165                170                175
Lys Pro Gly Asp Thr Gly Tyr Lys Ile Pro Arg Gly Gly Leu Phe Glu 
             180                185                190
Tyr Val Thr Ala Ala Asn Tyr Phe Gly Glu Ile Met Glu Trp Cys Gly 
         195                200                205
Tyr Ala Leu Ala Ser Trp Ser Val Gln Gly Ala Ala Phe Ala Phe Phe 
     210                215                220
Thr Phe Cys Phe Leu Ser Gly Arg Ala Lys Glu His His Glu Trp Tyr 
 225                230                235                240
Leu Arg Lys Phe Glu Glu Tyr Pro Lys Phe Arg Lys Ile Ile Ile Pro 
                 245                250                255
Phe Leu Phe 
             260



<210> 2593
<211> 2470
<212> DNA
<213> Rattus norvegicus
<308> J05035
<400> 2593

acctcagct  tggagttgg  tgagctgtg  ctgctcgac  tgctggtct  cttggaagg  60
ttcatggcc  tcgtgtcca  tgtggggct  cggtcggtt  gctctccgt  cggccgcta  120
tcgccgcag  ggcccggca  ccgagtgcc  gcgcgacct  cctggttca  acaggagct  180
ccctcgatg  cctggccgc  gtacgagta  attcgtcct  cagccgcgc  actgggcaa  240
ctgcctaac  gcgtcctgc  ggctatgtt  ctgatccac  acgtgcaaa  gacgctggt  300
ttcccggtt  tgatcaggg  agggaagcc  accctcctg  tcacctttg  cttggcctt  360
ctgttctgc  ccttcaacg  ctatgtaca  agcagatac  tgagccagt  tgcggttta  420
gctgaagac  gggtgaccc  tccctgttt  ctgacaggc  ttgccctgt  gttagtggg  480
atggtgata  atatccact  agaccacat  ctgaggaat  tgagaaaac  aggggaaac  540
ggatacaag  tacccaggg  aggcctgtt  gaatacgta  ctgcagcca  ctattttgg  600
gagctcgtg  agtggtgtg  ctttgcact  gccagctgg  ccctccagg  tgtagtgtt  660
gcactgttc  cactcagca  actgctcac  agagcgaag  agcaccatc  gtggtacca  720
gagaagttt  aagattacc  caagtcaag  aaaatactg  ttccatttg  gctttagtg  780
tctgttagc  ctgttgcct  ccatgagct  agtctgtct  tctccctgg  gactttgct  840
tgagcactt  cgaatgaat  gttttcctt  attctcctg  agccccttt  tcaggaaag  900
ctgggggtg  gggggtgtc  tcccctggt  aaggacaaa  ccaatgata  actaatcca  960
cacatgcag  taggggcta  actgcctgc  ggatccgaa  caggtagcc  tgagtcatt  1020
tggcgctct  tgacttcag  aatcagcag  ccttacaat  ctgcaagat  ccacccaag  1080
cagcagcag  cacgggcct  cttcactga  gtgtgttct  cctgctcag  ccctgccac  1140
gaggcctgg  ggtgtggga  tgtggccta  gcacagtct  ccatccttg  ccgcagacc  1200
cttggaccc  cccccactc  ctccagaca  tggtaagag  agccttcct  caacatgtc  1260
tgtcctcag  aggtgagac  gcagagtgc  tccattcac  cgatgaccc  atttttgct  1320
ttcctttgg  ctagaattc  ttaaggtcc  taaaaacaa  acaaaactt  ttcttaata  1380
tacaaaaca  aatatcaaa  caaaatttg  tattttgaa  gcacccaag  accaatcat  1440
tcacacaaa  aaagctcag  gctagcctg  gctgtgtag  gagaccctg  ttgggaaaa  1500
aaaaatgaa  ataacaacc  gctaactgt  caaagaagt  accgcagta  taaaagacg  1560
cgcccacac  ggcaccagc  tgggagaaa  atgtgcgcc  gggattgta  acccactgt  1620
gctctgggc  ggctgaggc  cactggtga  gagccattc  caccggacc  atgcacact  1680
cctcggggc  gcgtctgca  tcacctctc  cccgctgcc  ccacagcta  agaacagaa  1740
ggatagaac  gtgtgctct  aacccagtg  agatgctgc  tgaagacct  caggcacac  1800
tgatggcgt  cacggtgcc  accactcgc  tgactcgga  catctctgt  tgcccgctg  1860
cacctctgt  tgccctttc  agctggctt  cccatcagg  cttcctcag  tcttctgct  1920
tcagacaga  actattctc  gttcctctg  ttcgcagaa  gtctagatt  gacccagaa  1980
acttcatga  acagctact  cattttaac  aagagcagt  tttaatggg  aactaccct  2040
caatccttt  ccctcccct  ttctggcca  gtaactgct  gaaaaccta  agcactaaa  2100
attgtaggt  tcctctcaa  acctcaggc  tgtctggtg  gttctgaaa  gtttgtgtg  2160
aaggagata  tcagctgag  ccctgggaa  gtttgctgt  aacttgacc  cccttggag  2220
gcatggtgc  agataaact  ggaacctag  actccaggt  gctaggcgg  tgccctgac  2280
ctaagccac  tcacacatt  gctctgtga  gcctctttc  ttatgaagg  ccaagctgc  2340
cacatacta  gtgagatta  tttaagagg  atcctgtcc  aacactgta  acttcattc  2400
ctacaactc  acttacttg  atgaaccat  attgttaag  aaattaata  actacattt  2460
taagtaaaaa  2470



<210> 2594
<211> 259
<212> PRT
<213> Rattus norvegicus
<308> P24008
<400> 2594

Met Val Pro Leu Met Glu Leu Asp Glu Leu Cys Leu Leu Asp Met Leu 
  1               5                  10                  15
Val Tyr Leu Glu Gly Phe Met Ala Phe Val Ser Ile Val Gly Leu Arg 
             20                  25                  30
Ser Val Gly Ser Pro Tyr Gly Arg Tyr Ser Pro Gln Trp Pro Gly Ile 
         35                  40                  45
Arg Val Pro Ala Arg Pro Ala Trp Phe Ile Gln Glu Leu Pro Ser Met 
     50                  55                  60
Ala Trp Pro Leu Tyr Glu Tyr Ile Arg Pro Ala Ala Ala Arg Leu Gly 
 65                  70                  75                  80
Asn Leu Pro Asn Arg Val Leu Leu Ala Met Phe Leu Ile His Tyr Val 
                 85                  90                  95
Gln Arg Thr Leu Val Phe Pro Val Leu Ile Arg Gly Gly Lys Pro Thr 
             100                105                110
Leu Leu Val Thr Phe Val Leu Ala Phe Leu Phe Cys Thr Phe Asn Gly 
         115                120                125
Tyr Val Gln Ser Arg Tyr Leu Ser Gln Phe Ala Val Tyr Ala Glu Asp 
     130                135                140
Trp Val Thr His Pro Cys Phe Leu Thr Gly Phe Ala Leu Trp Leu Val 
 145                150                155                160
Gly Met Val Ile Asn Ile His Ser Asp His Ile Leu Arg Asn Leu Arg 
                 165                170                175
Lys Pro Gly Glu Thr Gly Tyr Lys Ile Pro Arg Gly Gly Leu Phe Glu 
             180                185                190
Tyr Val Ser Ala Ala Asn Tyr Phe Gly Glu Leu Val Glu Trp Cys Gly 
         195                200                205
Phe Ala Leu Ala Ser Trp Ser Leu Gln Gly Val Val Phe Ala Leu Phe 
     210                215                220
Thr Leu Ser Thr Leu Leu Thr Arg Ala Lys Gln His His Gln Trp Tyr 
 225                230                235                240
His Glu Lys Phe Glu Asp Tyr Pro Lys Ser Arg Lys Ile Leu Ile Pro 
                 245                250                255
Phe Val Leu 
             260



<210> 2595
<211> 2222
<212> DNA
<213> Homo sapiens
<308> NM_001047
<400> 2595

gagtcccgg  agtgcggga  tccggtagc  gcccctccg  tagccgccc  tcctccccc  60
gcgccgccg  cctatatgt  gcccgccgc  gcctctggg  catggagca  gctgcccag  120
cctggcgat  gcaacggcg  cgggggtgg  ggaggagcg  ctgctggcc  cgctcgcct  180
cctgcagtg  gccgtgggc  gcgcggtct  cgcgcggaa  cgtcagacg  actcagtgt  240
cggccgcca  gcgctgccc  gccacaggc  ccgagtgcc  gcgcgggcc  cctgggtgg  300
gcaggagct  ccctcgctg  ccctgccgc  ctaccagta  gccagcgag  ccgccccgc  360
tctccgcag  gcgcccaac  gcatcctcc  ggccatgtt  ctcgtccac  acgggcatc  420
gtgcttaat  tacccgttt  tgatgcgag  aggaaagcc  atgccactg  tggcatgta  480
aatggcgat  atgttctgt  cctgtaacg  ctatttgca  agcagatac  tgagccatt  540
tgcagtgta  gctgatgac  gggtaacag  tccccgttt  ctaataggt  ttggcttgt  600
gttaacagg  atgttgata  acatccatt  agatcatat  ctaaggaat  tcagaaaac  660
aggagatac  ggatacaaa  taccaaggg  aggcttatt  gaatacgta  ctgcagcca  720
ctattttgg  gaaatcatg  agtggtgtg  ctatgccct  gccagctgg  ctgtccaag  780
cgcggcttt  gctttcttc  cgttttgtt  tttatctgg  agagcaaaa  agcatcatg  840
gtggtacct  cggaaattt  aagagtatc  aaagttcag  aaaattata  ttccatttt  900
gttttaagt  cgtttttca  gaaattatc  tcaacttga  gctttccaa  ggcgcttct  960
tatggactt  gtaaataag  tatatcttt  taattttcc  gctacttta  cattttcaa  1020
atgtcctct  ggaattttt  ttctagtaa  tttgcaatc  acctaataa  tacctaaat  1080
cgctgaaat  gaggttgaa  atcctactg  gtaacaggt  agaatttca  gctctgggt  1140
ataactgct  atatttttt  taatttcaa  tttacctct  ttggctatg  cttgccaag  1200
gtgtatgag  ctagacttt  caactgtct  tgatggcat  ttcagaaca  taaatgtca  1260
aatcccttc  atagccccc  acagtgatc  cttcaaggt  aactgcagt  ttgcttccc  1320
ccccctata  ggctggaat  tgtctagga  ccctctctc  gaggccata  aggctgggg  1380
tagccattg  gcagtcatg  cccggggga  acttgccaa  cttcgtgtc  ggtgctgtg  1440
ataagtgga  aacttgggg  tagaggagg  agctcctcg  ggcccttcc  aggtgaggc  1500
aaggcatct  gacttgttc  agcccagcc  accgggtga  atcaccggg  agggagggg  1560
gctggtggt  gttcatacg  agtaagctg  tctgcctgt  tgagtggct  ctgggccct  1620
aacaggcac  tttaggcca  gggtcactc  ccgtgagcc  tcaatgtgc  ctggtctga  1680
atggtttct  tctgtcttc  agtctagac  tagtttttt  gttctgttc  ccacgtatg  1740
atatagtag  gattgttgt  tgtgaaatt  ctcttttgt  gattttgag  tttcccttg  1800
agtgtaaag  atgatcact  tctgtaaca  taacaagac  actttttaa  atttatcct  1860
tttgttctt  gttgattga  acataataa  tgttaaaat  ctctacagc  ttctttttc  1920
tccatagct  atcttcctt  taatagttt  tgctttctg  tttgctgtt  ttgctttgc  1980
aagctttcc  ctcatagcc  gtacctgtt  tcaatataa  ataatcttc  tgttgaatg  2040
ttcatgact  gaattctac  ttgataaaa  cattgccat  ctgcttttt  tcttgatga  2100
ttcatctgg  attgctttg  cttatcatc  catctggag  ttttaaatg  catttgttt  2160
agttgtctt  aacaacata  taaatagac  ttgccattt  aaaaaaaaa  aaaaaaaaa  2220
aa  2222



<210> 2596
<211> 259
<212> PRT
<213> Homo sapiens
<308> P18405
<400> 2596

Met Ala Thr Ala Thr Gly Val Ala Glu Glu Arg Leu Leu Ala Ala Leu 
  1               5                  10                  15
Ala Tyr Leu Gln Cys Ala Val Gly Cys Ala Val Phe Ala Arg Asn Arg 
             20                  25                  30
Gln Thr Asn Ser Val Tyr Gly Arg His Ala Leu Pro Ser His Arg Leu 
         35                  40                  45
Arg Val Pro Ala Arg Ala Ala Trp Val Val Gln Glu Leu Pro Ser Leu 
     50                  55                  60
Ala Leu Pro Leu Tyr Gln Tyr Ala Ser Glu Ser Ala Pro Arg Leu Arg 
 65                  70                  75                  80
Ser Ala Pro Asn Cys Ile Leu Leu Ala Met Phe Leu Val His Tyr Gly 
                 85                  90                  95
His Arg Cys Leu Ile Tyr Pro Phe Leu Met Arg Gly Gly Lys Pro Met 
             100                105                110
Pro Leu Leu Ala Cys Thr Met Ala Ile Met Phe Cys Thr Cys Asn Gly 
         115                120                125
Tyr Leu Gln Ser Arg Tyr Leu Ser His Cys Ala Val Tyr Ala Asp Asp 
     130                135                140
Trp Val Thr Asp Pro Arg Phe Leu Ile Gly Phe Gly Leu Trp Leu Thr 
 145                150                155                160
Gly Met Leu Ile Asn Ile His Ser Asp His Ile Leu Arg Asn Leu Arg 
                 165                170                175
Lys Pro Gly Asp Thr Gly Tyr Lys Ile Pro Arg Gly Gly Leu Phe Glu 
             180                185                190
Tyr Val Thr Ala Ala Asn Tyr Phe Gly Glu Ile Met Glu Trp Cys Gly 
         195                200                205
Tyr Ala Leu Ala Ser Trp Ser Val Gln Gly Ala Ala Phe Ala Phe Phe 
     210                215                220
Thr Phe Cys Phe Leu Ser Gly Arg Ala Lys Glu His His Glu Trp Tyr 
 225                230                235                240
Leu Arg Lys Phe Glu Glu Tyr Pro Lys Phe Arg Lys Ile Ile Ile Pro 
                 245                250                255
Phe Leu Phe 
             260



<210> 2597
<211> 2470
<212> DNA
<213> Rattus norvegicus
<308> J05035
<400> 2597

acctcagct  tggagttgg  tgagctgtg  ctgctcgac  tgctggtct  cttggaagg  60
ttcatggcc  tcgtgtcca  tgtggggct  cggtcggtt  gctctccgt  cggccgcta  120
tcgccgcag  ggcccggca  ccgagtgcc  gcgcgacct  cctggttca  acaggagct  180
ccctcgatg  cctggccgc  gtacgagta  attcgtcct  cagccgcgc  actgggcaa  240
ctgcctaac  gcgtcctgc  ggctatgtt  ctgatccac  acgtgcaaa  gacgctggt  300
ttcccggtt  tgatcaggg  agggaagcc  accctcctg  tcacctttg  cttggcctt  360
ctgttctgc  ccttcaacg  ctatgtaca  agcagatac  tgagccagt  tgcggttta  420
gctgaagac  gggtgaccc  tccctgttt  ctgacaggc  ttgccctgt  gttagtggg  480
atggtgata  atatccact  agaccacat  ctgaggaat  tgagaaaac  aggggaaac  540
ggatacaag  tacccaggg  aggcctgtt  gaatacgta  ctgcagcca  ctattttgg  600
gagctcgtg  agtggtgtg  ctttgcact  gccagctgg  ccctccagg  tgtagtgtt  660
gcactgttc  cactcagca  actgctcac  agagcgaag  agcaccatc  gtggtacca  720
gagaagttt  aagattacc  caagtcaag  aaaatactg  ttccatttg  gctttagtg  780
tctgttagc  ctgttgcct  ccatgagct  agtctgtct  tctccctgg  gactttgct  840
tgagcactt  cgaatgaat  gttttcctt  attctcctg  agccccttt  tcaggaaag  900
ctgggggtg  gggggtgtc  tcccctggt  aaggacaaa  ccaatgata  actaatcca  960
cacatgcag  taggggcta  actgcctgc  ggatccgaa  caggtagcc  tgagtcatt  1020
tggcgctct  tgacttcag  aatcagcag  ccttacaat  ctgcaagat  ccacccaag  1080
cagcagcag  cacgggcct  cttcactga  gtgtgttct  cctgctcag  ccctgccac  1140
gaggcctgg  ggtgtggga  tgtggccta  gcacagtct  ccatccttg  ccgcagacc  1200
cttggaccc  cccccactc  ctccagaca  tggtaagag  agccttcct  caacatgtc  1260
tgtcctcag  aggtgagac  gcagagtgc  tccattcac  cgatgaccc  atttttgct  1320
ttcctttgg  ctagaattc  ttaaggtcc  taaaaacaa  acaaaactt  ttcttaata  1380
tacaaaaca  aatatcaaa  caaaatttg  tattttgaa  gcacccaag  accaatcat  1440
tcacacaaa  aaagctcag  gctagcctg  gctgtgtag  gagaccctg  ttgggaaaa  1500
aaaaatgaa  ataacaacc  gctaactgt  caaagaagt  accgcagta  taaaagacg  1560
cgcccacac  ggcaccagc  tgggagaaa  atgtgcgcc  gggattgta  acccactgt  1620
gctctgggc  ggctgaggc  cactggtga  gagccattc  caccggacc  atgcacact  1680
cctcggggc  gcgtctgca  tcacctctc  cccgctgcc  ccacagcta  agaacagaa  1740
ggatagaac  gtgtgctct  aacccagtg  agatgctgc  tgaagacct  caggcacac  1800
tgatggcgt  cacggtgcc  accactcgc  tgactcgga  catctctgt  tgcccgctg  1860
cacctctgt  tgccctttc  agctggctt  cccatcagg  cttcctcag  tcttctgct  1920
tcagacaga  actattctc  gttcctctg  ttcgcagaa  gtctagatt  gacccagaa  1980
acttcatga  acagctact  cattttaac  aagagcagt  tttaatggg  aactaccct  2040
caatccttt  ccctcccct  ttctggcca  gtaactgct  gaaaaccta  agcactaaa  2100
attgtaggt  tcctctcaa  acctcaggc  tgtctggtg  gttctgaaa  gtttgtgtg  2160
aaggagata  tcagctgag  ccctgggaa  gtttgctgt  aacttgacc  cccttggag  2220
gcatggtgc  agataaact  ggaacctag  actccaggt  gctaggcgg  tgccctgac  2280
ctaagccac  tcacacatt  gctctgtga  gcctctttc  ttatgaagg  ccaagctgc  2340
cacatacta  gtgagatta  tttaagagg  atcctgtcc  aacactgta  acttcattc  2400
ctacaactc  acttacttg  atgaaccat  attgttaag  aaattaata  actacattt  2460
taagtaaaaa  2470



<210> 2598
<211> 259
<212> PRT
<213> Rattus norvegicus
<308> P24008
<400> 2598

Met Val Pro Leu Met Glu Leu Asp Glu Leu Cys Leu Leu Asp Met Leu 
  1               5                  10                  15
Val Tyr Leu Glu Gly Phe Met Ala Phe Val Ser Ile Val Gly Leu Arg 
             20                  25                  30
Ser Val Gly Ser Pro Tyr Gly Arg Tyr Ser Pro Gln Trp Pro Gly Ile 
         35                  40                  45
Arg Val Pro Ala Arg Pro Ala Trp Phe Ile Gln Glu Leu Pro Ser Met 
     50                  55                  60
Ala Trp Pro Leu Tyr Glu Tyr Ile Arg Pro Ala Ala Ala Arg Leu Gly 
 65                  70                  75                  80
Asn Leu Pro Asn Arg Val Leu Leu Ala Met Phe Leu Ile His Tyr Val 
                 85                  90                  95
Gln Arg Thr Leu Val Phe Pro Val Leu Ile Arg Gly Gly Lys Pro Thr 
             100                105                110
Leu Leu Val Thr Phe Val Leu Ala Phe Leu Phe Cys Thr Phe Asn Gly 
         115                120                125
Tyr Val Gln Ser Arg Tyr Leu Ser Gln Phe Ala Val Tyr Ala Glu Asp 
     130                135                140
Trp Val Thr His Pro Cys Phe Leu Thr Gly Phe Ala Leu Trp Leu Val 
 145                150                155                160
Gly Met Val Ile Asn Ile His Ser Asp His Ile Leu Arg Asn Leu Arg 
                 165                170                175
Lys Pro Gly Glu Thr Gly Tyr Lys Ile Pro Arg Gly Gly Leu Phe Glu 
             180                185                190
Tyr Val Ser Ala Ala Asn Tyr Phe Gly Glu Leu Val Glu Trp Cys Gly 
         195                200                205
Phe Ala Leu Ala Ser Trp Ser Leu Gln Gly Val Val Phe Ala Leu Phe 
     210                215                220
Thr Leu Ser Thr Leu Leu Thr Arg Ala Lys Gln His His Gln Trp Tyr 
 225                230                235                240
His Glu Lys Phe Glu Asp Tyr Pro Lys Ser Arg Lys Ile Leu Ile Pro 
                 245                250                255
Phe Val Leu 
             260



<210> 2599
<211> 2222
<212> DNA
<213> Homo sapiens
<308> NM_001047
<400> 2599

gagtcccgg  agtgcggga  tccggtagc  gcccctccg  tagccgccc  tcctccccc  60
gcgccgccg  cctatatgt  gcccgccgc  gcctctggg  catggagca  gctgcccag  120
cctggcgat  gcaacggcg  cgggggtgg  ggaggagcg  ctgctggcc  cgctcgcct  180
cctgcagtg  gccgtgggc  gcgcggtct  cgcgcggaa  cgtcagacg  actcagtgt  240
cggccgcca  gcgctgccc  gccacaggc  ccgagtgcc  gcgcgggcc  cctgggtgg  300
gcaggagct  ccctcgctg  ccctgccgc  ctaccagta  gccagcgag  ccgccccgc  360
tctccgcag  gcgcccaac  gcatcctcc  ggccatgtt  ctcgtccac  acgggcatc  420
gtgcttaat  tacccgttt  tgatgcgag  aggaaagcc  atgccactg  tggcatgta  480
aatggcgat  atgttctgt  cctgtaacg  ctatttgca  agcagatac  tgagccatt  540
tgcagtgta  gctgatgac  gggtaacag  tccccgttt  ctaataggt  ttggcttgt  600
gttaacagg  atgttgata  acatccatt  agatcatat  ctaaggaat  tcagaaaac  660
aggagatac  ggatacaaa  taccaaggg  aggcttatt  gaatacgta  ctgcagcca  720
ctattttgg  gaaatcatg  agtggtgtg  ctatgccct  gccagctgg  ctgtccaag  780
cgcggcttt  gctttcttc  cgttttgtt  tttatctgg  agagcaaaa  agcatcatg  840
gtggtacct  cggaaattt  aagagtatc  aaagttcag  aaaattata  ttccatttt  900
gttttaagt  cgtttttca  gaaattatc  tcaacttga  gctttccaa  ggcgcttct  960
tatggactt  gtaaataag  tatatcttt  taattttcc  gctacttta  cattttcaa  1020
atgtcctct  ggaattttt  ttctagtaa  tttgcaatc  acctaataa  tacctaaat  1080
cgctgaaat  gaggttgaa  atcctactg  gtaacaggt  agaatttca  gctctgggt  1140
ataactgct  atatttttt  taatttcaa  tttacctct  ttggctatg  cttgccaag  1200
gtgtatgag  ctagacttt  caactgtct  tgatggcat  ttcagaaca  taaatgtca  1260
aatcccttc  atagccccc  acagtgatc  cttcaaggt  aactgcagt  ttgcttccc  1320
ccccctata  ggctggaat  tgtctagga  ccctctctc  gaggccata  aggctgggg  1380
tagccattg  gcagtcatg  cccggggga  acttgccaa  cttcgtgtc  ggtgctgtg  1440
ataagtgga  aacttgggg  tagaggagg  agctcctcg  ggcccttcc  aggtgaggc  1500
aaggcatct  gacttgttc  agcccagcc  accgggtga  atcaccggg  agggagggg  1560
gctggtggt  gttcatacg  agtaagctg  tctgcctgt  tgagtggct  ctgggccct  1620
aacaggcac  tttaggcca  gggtcactc  ccgtgagcc  tcaatgtgc  ctggtctga  1680
atggtttct  tctgtcttc  agtctagac  tagtttttt  gttctgttc  ccacgtatg  1740
atatagtag  gattgttgt  tgtgaaatt  ctcttttgt  gattttgag  tttcccttg  1800
agtgtaaag  atgatcact  tctgtaaca  taacaagac  actttttaa  atttatcct  1860
tttgttctt  gttgattga  acataataa  tgttaaaat  ctctacagc  ttctttttc  1920
tccatagct  atcttcctt  taatagttt  tgctttctg  tttgctgtt  ttgctttgc  1980
aagctttcc  ctcatagcc  gtacctgtt  tcaatataa  ataatcttc  tgttgaatg  2040
ttcatgact  gaattctac  ttgataaaa  cattgccat  ctgcttttt  tcttgatga  2100
ttcatctgg  attgctttg  cttatcatc  catctggag  ttttaaatg  catttgttt  2160
agttgtctt  aacaacata  taaatagac  ttgccattt  aaaaaaaaa  aaaaaaaaa  2220
aa  2222



<210> 2600
<211> 259
<212> PRT
<213> Homo sapiens
<308> P18405
<400> 2600

Met Ala Thr Ala Thr Gly Val Ala Glu Glu Arg Leu Leu Ala Ala Leu 
  1               5                  10                  15
Ala Tyr Leu Gln Cys Ala Val Gly Cys Ala Val Phe Ala Arg Asn Arg 
             20                  25                  30
Gln Thr Asn Ser Val Tyr Gly Arg His Ala Leu Pro Ser His Arg Leu 
         35                  40                  45
Arg Val Pro Ala Arg Ala Ala Trp Val Val Gln Glu Leu Pro Ser Leu 
     50                  55                  60
Ala Leu Pro Leu Tyr Gln Tyr Ala Ser Glu Ser Ala Pro Arg Leu Arg 
 65                  70                  75                  80
Ser Ala Pro Asn Cys Ile Leu Leu Ala Met Phe Leu Val His Tyr Gly 
                 85                  90                  95
His Arg Cys Leu Ile Tyr Pro Phe Leu Met Arg Gly Gly Lys Pro Met 
             100                105                110
Pro Leu Leu Ala Cys Thr Met Ala Ile Met Phe Cys Thr Cys Asn Gly 
         115                120                125
Tyr Leu Gln Ser Arg Tyr Leu Ser His Cys Ala Val Tyr Ala Asp Asp 
     130                135                140
Trp Val Thr Asp Pro Arg Phe Leu Ile Gly Phe Gly Leu Trp Leu Thr 
 145                150                155                160
Gly Met Leu Ile Asn Ile His Ser Asp His Ile Leu Arg Asn Leu Arg 
                 165                170                175
Lys Pro Gly Asp Thr Gly Tyr Lys Ile Pro Arg Gly Gly Leu Phe Glu 
             180                185                190
Tyr Val Thr Ala Ala Asn Tyr Phe Gly Glu Ile Met Glu Trp Cys Gly 
         195                200                205
Tyr Ala Leu Ala Ser Trp Ser Val Gln Gly Ala Ala Phe Ala Phe Phe 
     210                215                220
Thr Phe Cys Phe Leu Ser Gly Arg Ala Lys Glu His His Glu Trp Tyr 
 225                230                235                240
Leu Arg Lys Phe Glu Glu Tyr Pro Lys Phe Arg Lys Ile Ile Ile Pro 
                 245                250                255
Phe Leu Phe 
             260



<210> 2601
<211> 5084
<212> DNA
<213> Rattus norvegicus
<308> J05087
<400> 2601

caccaccag  tccctccct  ccccacccc  tcctccctc  ctccgcgct  agagctgcg  60
ctggagtcg  gcgcgcgcg  cgcccgccg  cgccggtgc  gagcgtggg  agcactcgg  120
cacagccct  gcctggccg  ggagggtcc  gctccgcac  gctggccag  ccgcccagt  180
cccgggcct  tccgtcctt  gagcggatc  ttgctcgca  ggagctctc  tgcagcaac  240
gcgaaagct  cagcagagg  cgcggtggc  gctgtgccc  tgccgggca  ccaagagtc  300
ctcaaaagg  cctcccctc  actgatgcc  tctatctgt  ctgtggcct  ttgggtgaa  360
gaagatgag  aaagtttga  tagccacac  ttctggctt  atgctgtgc  ggatagtgc  420
gctaccttc  agagctcca  gattttccc  tctgtgaac  aggcctcat  cactaattt  480
tccagcccc  tcgtcatct  ggatagatc  ctcagtgca  ttttggcaa  tcagtggtc  540
acaatgtgt  tcaaagagt  aaggatgca  gtgttcaca  ttagcttct  tcccaccac  600
accttgcct  acctcagca  tgggatcat  ggtggccac  cgtccctag  tattactga  660
ctgaggcta  acctgtgag  aggctgaca  acaggatgg  tgacatggc  aacagttcc  720
ttgagttcc  ccccaaacc  cagcagcag  gggaagtgc  tcatgtggg  ggctttgga  780
gcacgctgg  agaactacg  agcctcatg  agctccgag  tgctgaggc  ctgcagaag  840
tccaagaag  ctatgggga  gtcagtggg  tgtgtagga  actaaagac  tcacctact  900
aaggcctgg  agacaacac  aatgacttg  agaaacgca  gcagatcta  gggcagaac  960
tcatccctc  aaagcagcc  aagaccttc  tgcagctgg  gtgggaagc  ctgcaggac  1020
tgactctca  catcctgga  gtggctgct  tcgtctccc  gggcctctc  ttctatgca  1080
cacctggag  ggaaagtga  gcctgtggg  atgtgtctg  tggggcaga  gacgaagga  1140
aggccgagg  tggctggat  gagggggct  ccatcctac  ctctgtcat  tgtgtggtg  1200
tggtcacag  cttcaatga  tggagcaag  aaaagcagt  ccgaggtct  cagagccga  1260
ttgagcagg  acagaagtt  actgtcatc  gaaatgggc  gctcctcca  gtccctgtg  1320
cagccctgg  ggtagggga  attgcccag  tcaaatacg  agatcttct  cctgccgat  1380
gtgtgctca  ccaaggcaa  gacctcaag  tcgacgaga  ctccctgac  ggcgagtcg  1440
accatgtgc  caaatcagc  gacaaagat  ctatgctgc  ctcaggcac  catgtcatg  1500
aaggttctg  aagaatggt  gtaacagct  ttggtgtga  ctcccagac  ggcatcatc  1560
ttacattgc  tggggcagg  ggagaggag  aggagaaga  agacaagaa  gctaagaag  1620
aggatgggg  tgttgccat  gaaatgcag  ccctgaaga  tgccgaggg  ggggaaatg  1680
aggagcggg  aaagaagaa  gccaacgta  ccaagaagg  gaagtcagt  ctgcaaggg  1740
agctcacaa  actggctgt  cagattggg  aagcaggat  ggtgatgtc  gctatcact  1800
tcatcattc  ggtcctcta  tttgtgatt  agaccttcg  tgtggatgg  cgggtgtgg  1860
tggcagagt  cacaccagt  tatgtgcag  actttgtga  gtttttcat  attggagtc  1920
ctgtgttgg  tgtggctgt  cctgagggc  tgcctcttg  tgttactat  tccttggct  1980
actctgtta  gaaaatgat  aaggacaat  acctggtac  ccacctgga  gcctgtgag  2040
ccatgggca  tgccacagc  atctgttct  acaagacag  cacactcac  accaaccgt  2100
tgacagtgg  tcagtccta  ctaggagac  cccactaca  agagattcc  gctcccagc  2160
ccctgaccc  caagatcct  gaccttctg  ttcatgcca  ctccatcaa  agtgcctac  2220
ccaccaaaa  tctacctcc  gagaaagaa  gcgctctcc  acgccaagt  ggcaacaaa  2280
cagagtgtg  tcttttggg  ttcatcttg  acctgaaac  tgacttcca  cctgtacgg  2340
aacagatac  agaagatca  ctttacaaa  tgtacacct  caactcagt  cgcaagtcc  2400
tgagcacag  tatccgaat  cctgatggt  gcttccgcc  cttcagcaa  ggagcctca  2460
agatcctgc  caaaaagtg  acaaacatc  taaacagca  tggtgaact  cgaggattt  2520
gtcctcggg  ccgggatga  atggtaaag  agatcattg  gcctatggc  tgtgatggc  2580
tccgcacca  atgcatcgc  tacagggac  tctctgcta  ccaggaacc  gactgggac  2640
atgagaatg  ggtggtggg  gaccttacc  gcatagctg  cgtgggcat  gaggaccct  2700
tgcgacctg  ggtccctga  gccattcga  aatgccagc  tgctggcat  acagtccgt  2760
tggtaactg  agataacat  aacactgcc  gggctattg  agctaagtg  ggcatcatc  2820
agccagggg  ggatttcct  tgcctggag  ggaaggaat  caacagaag  attcgaaat  2880
agaaaggcg  gatagaaca  gagaggctg  acaaggtgt  gcccaagct  cgggtgctt  2940
cccggtcat  tcccactga  aaacatact  tggtcaaag  cataattga  agcacaact  3000
gtgagcagc  gcaggtggt  gctgtgacc  gggatggca  caatgatgg  ccagccctc  3060
aaaaggcag  tgtgggctt  gccatgggc  tcgcaggca  tgatgtggc  aaggaggcc  3120
ctgacatca  tctgactga  gacaacttc  ccagcattg  caaggcggt  atgtggggc  3180
gcaatgtct  tgacagcat  tccaagttc  tgcagtttc  gttgacagt  aatgtggta  3240
ctgtgatcg  ggccttcac  ggtgcctgc  ttactcagg  ctctcctct  aaagctgtg  3300
agatgttgt  ggtgaactt  atcatggac  catttgcct  acttgccct  gcaacggaa  3360
ccccaactg  gtcactgct  ctgcggaag  catatggcc  ggacaagcc  ctcatctca  3420
gcaccatga  gaagaacat  cttggacat  ctgtttacc  gcttaccat  atctttact  3480
tgctatttg  tggagagct  ttctttgac  ttgacagtg  aaggaatgc  cctctgcac  3540
cgccgccct  agagcacta  accatcatc  tcaacacat  tgtcatgat  cagcttttc  3600
atgagatca  tgctcgaaa  atccatggt  agaggaatg  ctttgatgg  atcttcagc  3660
accccatct  ctgtaccat  gtcctgggc  cctttggaa  tcagattgt  attgtccaa  3720
ttggaggga  gcccttcag  tgttcccca  tgtccacag  acagtggct  tggtgtctt  3780
ttgttggtg  tggggagct  gtctgggga  aggtcattg  cactatccc  accagccag  3840
tcaagtgcc  gaaggaagc  gggcatggg  ctgggaagg  tgagatgac  gatgaagag  3900
tggcggaag  ggaagaaga  attgaccat  ctgagcgag  gctccgcag  ggccagatc  3960
tctggtttc  gggcctcaa  cggatccag  cacagatgg  ggtagtgag  accttcaag  4020
gaagcgggt  atttcaggg  gctgtgcgc  ggcggtctt  ggtcctcag  cagctccat  4080
acgtaacca  tctttctac  cctactcac  taactctct  tgccgccaa  cccaccagc  4140
ctgctggca  tccgagtgg  gaaagcatt  cgtagctcg  tttatgaag  cctggagaa  4200
ccagaatcc  agagttgca  ccataactt  atggcaaca  ccgagtttt  gatcaatga  4260
tacacccac  atattccgc  catcgatga  acagatgtg  atgagaatg  agagcgcct  4320
agggcccca  ctcccccac  ccctaacca  aacaacaac  ccatagaca  cggcatcta  4380
ctgaccacg  atgccacca  gtcagctac  tcttcagca  tctcttcca  gcctgggag  4440
ccactccac  gcatggaga  atccctcta  ccagaactt  tctcagtgt  cgcgtgcgc  4500
cgcgcacac  cacacacac  cacacacac  cacactctc  cacacacac  catattctc  4560
ctcacacac  cacatacac  tacatgcat  catgcacat  cattctctc  ctttctctt  4620
cacacacac  cacacacac  cacacgcgc  cgcgcacag  cacatgcac  cagagaggg  4680
aacccgtgc  cctgccaaa  agggaaatg  ctaacatgg  taaagactt  acttatgtg  4740
tatttgcaa  aagccaatt  cattcaata  gaggacagc  cactaggct  tttactagg  4800
tcccagaag  tgggggaag  agaaaaaag  aaaagagag  gaggttctt  acccgatgt  4860
aaggaaaaa  agagcatga  acaagatac  cttcccacc  tttttctac  gatgcttct  4920
tttttaatg  acactagtt  caccatgtg  tcactattt  ggctgtgca  tgcggtagg  4980
gctagctga  cctatttgg  gctttgcta  acccataac  aaaaaaaag  aaagaaaaa  5040
aaagaaaga  agaaagaaa  aaagaaaga  agaaagaaa  aaag  5084



<210> 2602
<211> 1258
<212> PRT
<213> Rattus norvegicus
<308> AAA69667
<400> 2602

Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln 
  1               5                  10                  15
Gln Gln Arg Glu Val Pro His Val Gly Gly Phe Gly Cys Thr Leu Ala 
             20                  25                  30
Glu Leu Arg Ser Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys 
         35                  40                  45
Ile Gln Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys 
     50                  55                  60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys 
 65                  70                  75                  80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys 
                 85                  90                  95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
             100                105                110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala 
         115                120                125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala 
     130                135                140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile 
 145                150                155                160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp 
                 165                170                175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu 
             180                185                190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val 
         195                200                205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu 
     210                215                220
Leu Pro Ala Asp Gly Val Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp 
 225                230                235                240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp 
                 245                250                255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly 
             260                265                270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile 
         275                280                285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys 
     290                295                300
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala 
 305                310                315                320
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser 
                 325                330                335
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Val 
             340                345                350
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala 
         355                360                365
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile 
     370                375                380
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Asp Gly Arg 
 385                390                395                400
Val Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys 
                 405                410                415
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly 
             420                425                430
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met 
         435                440                445
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met 
     450                455                460
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr 
 465                470                475                480
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys 
                 485                490                495
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu 
             500                505                510
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro 
         515                520                525
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu 
     530                535                540
Cys Ala Leu Leu Gly Phe Ile Leu Asp Leu Lys Arg Asp Phe Gln Pro 
 545                550                555                560
Val Arg Glu Gln Ile Pro Glu Asp Gln Leu Tyr Lys Val Tyr Thr Phe 
                 565                570                575
Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Met Pro Asp Gly 
             580                585                590
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys 
         595                600                605
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro 
     610                615                620
Arg Asp Arg Asp Asp Met Val Lys Lys Ile Ile Glu Pro Met Ala Cys 
 625                630                635                640
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Ser Ala Ile 
                 645                650                655
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr 
             660                665                670
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro 
         675                680                685
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val 
     690                695                700
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly 
 705                710                715                720
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe 
                 725                730                735
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu 
             740                745                750
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr 
         755                760                765
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu 
     770                775                780
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro 
 785                790                795                800
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr 
                 805                810                815
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe 
             820                825                830
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser 
         835                840                845
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val 
     850                855                860
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys 
 865                870                875                880
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser 
                 885                890                895
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys 
             900                905                910
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn 
         915                920                925
Ile Leu Gly His Ala Val Tyr Gln Leu Thr Ile Ile Phe Thr Leu Leu 
     930                935                940
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro 
 945                950                955                960
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe 
                 965                970                975
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly 
             980                985                990
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr 
         995                1000                1005
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly 
     1010                1015                1020
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp 
 1025                1030                1035                1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala 
                 1045                1050                1055
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly 
             1060                1065                1070
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu 
         1075                1080                1085
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp 
     1090                1095                1100
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Glu Val Val Ser Thr 
 1105                1110                1115                1120
Phe Lys Arg Ser Gly Ser Phe Gln Gly Ala Val Arg Arg Arg Ser Ser 
                 1125                1130                1135
Val Leu Ser Gln Leu His Asp Val Thr Asn Leu Ser Thr Pro Thr His 
             1140                1145                1150
Ile Arg Val Val Lys Ala Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu 
         1155                1160                1165
Lys Pro Glu Ser Lys Ser Cys Ile His Asn Phe Met Ala Thr Pro Glu 
     1170                1175                1180
Phe Leu Ile Asn Asp Tyr Thr His Asn Ile Pro Leu Ile Asp Asp Thr 
 1185                1190                1195                1200
Asp Val Asp Glu Asn Glu Glu Arg Leu Arg Ala Pro Pro Pro Pro Pro 
                 1205                1210                1215
Pro Asn Gln Asn Asn Asn Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr 
             1220                1225                1230
His Ala Thr Lys Ser Ala Thr Ser Ser Ala Phe Ser Ser Arg Pro Gly 
         1235                1240                1245
Ser Pro Leu His Ser Met Glu Thr Ser Leu 
     1250                1255



<210> 2603
<211> 4398
<212> DNA
<213> Homo sapiens
<308> NM_001682
<400> 2603

ggccaaagg  caagatact  ctctgggaa  tgttgctgc  gatgctgct  tacaaagtc  60
tacaatgag  gtttggttt  agaaagatt  tcatactta  aagattttc  tcttggaaa  120
acatcaagt  aaaattaaa  tcttttggg  aacattttc  ttctgatat  ttatacttg  180
aatgggcga  atggcaaac  actcagttg  ttacagtgg  gtgaaaaac  ctttgaagg  240
agctaatca  gatggagac  ttggaatta  gctcgcaga  ctgcgggct  tcatggagc  300
caggtccac  gatgcatta  gaaaaatac  ggaaagcta  ggagatgtc  atggaattt  360
caccaaatt  aaaacatct  ccaatgaag  tttaagtgg  aaccctgca  atttagaaa  420
aagagaagc  gtgtttgga  agaatttta  acctcctaa  aagccaaaa  cctttcttc  480
attagtatg  gaagcatta  aagatgtca  tttaattat  ttagaaatt  cagccatag  540
atcattggg  ctttctttt  atcagcctc  agaagggga  aatgcactt  gtggagaag  600
ttctgttgg  gaggaagaa  gtgaaggtg  aactgggtg  attgaagga  ctgcaatcc  660
cttgtctgt  gtgtgtgtg  tgttagtaa  agctttcaa  gactggagt  aggagaaac  720
gtttagagg  ttgcagagc  gaattgaac  agaacagaa  ttcactgtc  tcaggggtg  780
tcaggtcat  cagatacct  tagctgaca  tactgttgg  gatattgct  aagtgaaat  840
tggtgatct  cttccagct  acggcatac  tattcaagg  aacgatctt  aaattgatg  900
aagctcatt  actggtgaa  cagatcatg  taaaaagtc  ttagataag  atcccttac  960
tctatcagg  actcatgta  gggaaggct  tggaagaat  gtagttaca  ctgtaggtg  1020
aaattctca  actggaatt  tctttacct  acttggagc  ggaggtgaa  aggaagaga  1080
gaaagatga  aagaaaaag  aaaagaaaa  taagaaaca  gatggagct  ttgagaatc  1140
caacaaagc  aaagcccag  atggtgcag  catggaaat  cagccattg  agagtgaag  1200
aggtggaga  ggtgatgaa  aagataaaa  gaaagcaaa  ttgccaaaa  aggaaaaat  1260
tgttttaca  gggaaactt  caaaactgg  tgttcagat  ggcaaagca  gtctgttga  1320
gtctgccat  acagttatc  ttctagtat  atattttgt  attgacacc  tctgggttc  1380
gaaaagacc  tggcttgct  agtgcacac  aatttatat  caatacttt  tgaagttct  1440
cattattgg  gttacagtt  tagtggtcg  agtgccaga  ggtcttcca  ttgcagtca  1500
gatctcact  gcttattca  tcaaaaaaa  gatgaaaga  aataactta  taaggcatc  1560
ggatgcttg  gaaaccatg  gaaatgcta  agctatttg  tcagataaa  caggaactt  1620
gacaatgaa  agaatgaca  tcgttcaag  ttacataaa  gaaaaacat  ataaaaagg  1680
tcctgaacc  gaagctatt  caccaaata  tttgtccta  cttgtaaca  gaatttctg  1740
gaattgtgc  tatacatca  aaatattgc  accagagaa  gagggtgga  tacctcgtc  1800
cgttggtaa  aaaactgaa  gtgccttgt  gggacttct  ttggattta  aacgggatt  1860
tcaggatgt  agaaatgaa  taccagaag  agcactgta  aaagtctac  ccttcaatt  1920
tgttaggaa  tccatgagt  ctgtcctga  aaattcaga  ggaagttat  gaatattca  1980
caagggtgc  tctgagata  ttctgaaaa  gtgtttcaa  atcttgagt  ctaatggtg  2040
ggcaaaagt  ttcagacca  gggaccgtg  tgatattgt  aaaactgtg  ttgaaccga  2100
ggcatcaga  ggcttgaga  ccatatgtc  tgcattcag  gattttcca  caggagaac  2160
agaaccaga  tgggataat  aaaatgata  tgtcaccgg  cttacatgc  ttgctgttg  2220
ggggattga  gatcctgtg  gacctgagg  gccagatgc  attaaaaag  gtcagaggg  2280
tggaattac  gtgcggatg  tcactggtg  taatattaa  actgctcgg  ccattgcta  2340
caaatgtgg  attttacat  ctggggaag  ttttctgtg  ctagaaggt  aagatttta  2400
cagaagaat  cgaaatgaa  aaggagaga  tgagcaaga  aggatagac  agatttggc  2460
aaaacttcg  gtacttgca  gatcatctc  tactgataa  catacactg  ttaaaggta  2520
aattgacag  actgtctca  accaacgcc  ggttgtagc  gtaactggt  atggtacaa  2580
tgatggccc  gcactaaag  aagcagatg  tggatttgc  atgggtatt  ctggaactg  2640
tgtagctaa  gaagcatcc  atattattc  cacagatga  aactttaca  gcattgtta  2700
agcagttat  tggggacga  atgtctatg  cagcatctc  aaattcctt  agttccaac  2760
tactgttaa  gtagtagca  tgattgttg  ttttacggg  gcctgcatt  ctcaagact  2820
accgcttaa  gctgtgcag  tgctgtggg  aaacctcat  atggataca  tcgcttccc  2880
ggctctggc  acggaacca  ccactgagt  tctcttgct  cggaaacct  atggtagaa  2940
taagcctct  atctcacgt  caatgatga  gaatatttt  ggtcatgca  tctatcaac  3000
tgtagtagt  tttacactc  tatttgctg  agaaaagtt  tttgacatt  atagtggaa  3060
aaatgctcc  ttgcatgct  ctccttcag  acattatac  attgttttt  atacctttg  3120
gctgatgca  cttttcaac  aaataaatg  ccggaaaat  catggtgaa  gaaatgtat  3180
cgaaggaat  tttaacaat  ccatcttct  cacaattgt  ttaggcact  ttgtggtac  3240
gataataat  gtgcagttt  gtggaaaac  tttcagttg  tcagaactt  caatagaac  3300
gtggctatg  tcaatattc  taggaatgg  aacattact  tggggccag  ttatttcaa  3360
aattccaac  agccgttta  aattcctca  agaagctgg  catggaaca  aaaaggaag  3420
aatacctga  gaggaatta  cagaggatg  tgaagagat  gatcacgct  aaagggagt  3480
gcggcgtgg  caaatcttg  ggtttagag  tctgaacag  atccaaaca  agattcgag  3540
ggtgaatgc  tttcgtagt  ctttatatg  agggttaga  aaaccggaa  caagaagtt  3600
gattcacaa  tttatgaca  atcctgagt  taggataga  gattcagag  ctcatatcc  3660
ccttattga  gacactgat  ccgaagatg  tgctcctac  aaacgtaac  ccagtcctc  3720
accctctcc  aacaaaaat  acaatgctg  tgacagtgg  attcacctt  caatagaaa  3780
gaacaagtc  gctacctct  catccccag  aagcccact  catagtttg  aaacatcac  3840
ctgattgta  gctgaatgt  aacacacta  ctgcattgt  aagaaacaa  ttgaaactg  3900
gtcttttca  atattgtga  ggacaagct  gtattcttg  ctttggact  caacagaag  3960
cacacttgt  cgaatgtag  tttattttt  taaaaaaaa  aaagcaaag  tttctgcca  4020
actgagggt  ctttttggg  ggtgggaga  atgaactga  agataaaca  taactcagc  4080
taagtgacc  gtggatcat  agtagtacc  aagcatggt  ctgaacagt  tattagcag  4140
gctttagtt  atctcagtc  tggatggga  agagaggga  gagtaaaac  gggcaagac  4200
aagagccct  gatcgttga  ttgatagtt  aatttctgc  gttggctgt  aataatttg  4260
attatttat  tttataaat  atacagatc  gtttacaag  tttgtagat  ctttttttg  4320
tcctgttca  agatgggaa  cttccttat  actgatgca  agaaaaatt  gtccttcaa  4380
tactgctgt  ttttcagg  4398



<210> 2604
<211> 1258
<212> PRT
<213> Homo sapiens
<308> P20020
<400> 2604

Met Gly Asp Met Ala Asn Asn Ser Val Ala Tyr Ser Gly Val Lys Asn 
  1               5                  10                  15
Ser Leu Lys Glu Ala Asn His Asp Gly Asp Phe Gly Ile Thr Leu Ala 
             20                  25                  30
Glu Leu Arg Ala Leu Met Glu Leu Arg Ser Thr Asp Ala Leu Arg Lys 
         35                  40                  45
Ile Gln Glu Ser Tyr Gly Asp Val Tyr Gly Ile Cys Thr Lys Leu Lys 
     50                  55                  60
Thr Ser Pro Asn Glu Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Arg 
 65                  70                  75                  80
Arg Glu Ala Val Phe Gly Lys Asn Phe Ile Pro Pro Lys Lys Pro Lys 
                 85                  90                  95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
             100                105                110
Ile Leu Glu Ile Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Gln 
         115                120                125
Pro Pro Glu Gly Asp Asn Ala Leu Cys Gly Glu Val Ser Val Gly Glu 
     130                135                140
Glu Glu Gly Glu Gly Glu Thr Gly Trp Ile Glu Gly Ala Ala Ile Leu 
 145                150                155                160
Leu Ser Val Val Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser 
                 165                170                175
Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln 
             180                185                190
Lys Phe Thr Val Ile Arg Gly Gly Gln Val Ile Gln Ile Pro Val Ala 
         195                200                205
Asp Ile Thr Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu 
     210                215                220
Pro Ala Asp Gly Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu 
 225                230                235                240
Ser Ser Leu Thr Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys 
                 245                250                255
Asp Pro Leu Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg 
             260                265                270
Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe 
         275                280                285
Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Glu Lys 
     290                295                300
Lys Lys Glu Lys Lys Asn Lys Lys Gln Asp Gly Ala Ile Glu Asn Arg 
 305                310                315                320
Asn Lys Ala Lys Ala Gln Asp Gly Ala Ala Met Glu Met Gln Pro Leu 
                 325                330                335
Lys Ser Glu Glu Gly Gly Asp Gly Asp Glu Lys Asp Lys Lys Lys Ala 
             340                345                350
Asn Leu Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys 
         355                360                365
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Leu Met Ser Ala Ile Thr 
     370                375                380
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Asp Thr Phe Trp Val Gln 
 385                390                395                400
Lys Arg Pro Trp Leu Ala Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe 
                 405                410                415
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro 
             420                425                430
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys 
         435                440                445
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu 
     450                455                460
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu 
 465                470                475                480
Thr Met Asn Arg Met Thr Val Val Gln Ala Tyr Ile Asn Glu Lys His 
                 485                490                495
Tyr Lys Lys Val Pro Glu Pro Glu Ala Ile Pro Pro Asn Ile Leu Ser 
             500                505                510
Tyr Leu Val Thr Gly Ile Ser Val Asn Cys Ala Tyr Thr Ser Lys Ile 
         515                520                525
Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro Arg His Val Gly Asn Lys 
     530                535                540
Thr Glu Cys Ala Leu Leu Gly Leu Leu Leu Asp Leu Lys Arg Asp Tyr 
 545                550                555                560
Gln Asp Val Arg Asn Glu Ile Pro Glu Glu Ala Leu Tyr Lys Val Tyr 
                 565                570                575
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Leu Lys Asn Ser 
             580                585                590
Asp Gly Ser Tyr Arg Ile Phe Ser Lys Gly Ala Ser Glu Ile Ile Leu 
         595                600                605
Lys Lys Cys Phe Lys Ile Leu Ser Ala Asn Gly Glu Ala Lys Val Phe 
     610                615                620
Arg Pro Arg Asp Arg Asp Asp Ile Val Lys Thr Val Ile Glu Pro Met 
 625                630                635                640
Ala Ser Glu Gly Leu Arg Thr Ile Cys Leu Ala Phe Arg Asp Phe Pro 
                 645                650                655
Ala Gly Glu Pro Glu Pro Glu Trp Asp Asn Glu Asn Asp Ile Val Thr 
             660                665                670
Gly Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro 
         675                680                685
Glu Val Pro Asp Ala Ile Lys Lys Cys Gln Arg Ala Gly Ile Thr Val 
     690                695                700
Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Thr 
 705                710                715                720
Lys Cys Gly Ile Leu His Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly 
                 725                730                735
Lys Asp Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln 
             740                745                750
Glu Arg Ile Asp Lys Ile Trp Pro Lys Leu Arg Val Leu Ala Arg Ser 
         755                760                765
Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr 
     770                775                780
Val Ser Asp Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn 
 785                790                795                800
Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile 
                 805                810                815
Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp 
             820                825                830
Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val 
         835                840                845
Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val 
     850                855                860
Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser 
 865                870                875                880
Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr 
                 885                890                895
Leu Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu 
             900                905                910
Leu Arg Lys Pro Tyr Gly Arg Asn Lys Pro Leu Ile Ser Arg Thr Met 
         915                920                925
Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu Val Val Val Phe 
     930                935                940
Thr Leu Leu Phe Ala Gly Glu Lys Phe Phe Asp Ile Asp Ser Gly Arg 
 945                950                955                960
Asn Ala Pro Leu His Ala Pro Pro Ser Glu His Tyr Thr Ile Val Phe 
                 965                970                975
Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys 
             980                985                990
Ile His Gly Glu Arg Asn Val Phe Glu Gly Ile Phe Asn Asn Ala Ile 
         995                1000                1005
Phe Cys Thr Ile Val Leu Gly Thr Phe Val Val Gln Ile Ile Ile Val 
     1010                1015                1020
Gln Phe Gly Gly Lys Pro Phe Ser Cys Ser Glu Leu Ser Ile Glu Gln 
 1025                1030                1035                1040
Trp Leu Trp Ser Ile Phe Leu Gly Met Gly Thr Leu Leu Trp Gly Gln 
                 1045                1050                1055
Leu Ile Ser Thr Ile Pro Thr Ser Arg Leu Lys Phe Leu Lys Glu Ala 
             1060                1065                1070
Gly His Gly Thr Gln Lys Glu Glu Ile Pro Glu Glu Glu Leu Ala Glu 
         1075                1080                1085
Asp Val Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln 
     1090                1095                1100
Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Asp Val 
 1105                1110                1115                1120
Val Asn Ala Phe Gln Ser Gly Ser Ser Ile Gln Gly Ala Leu Arg Arg 
                 1125                1130                1135
Gln Pro Ser Ile Ala Ser Gln His His Asp Val Thr Asn Ile Ser Thr 
             1140                1145                1150
Pro Thr His Ile Arg Val Val Asn Ala Phe Arg Ser Ser Leu Tyr Glu 
         1155                1160                1165
Gly Leu Glu Lys Pro Glu Ser Arg Ser Ser Ile His Asn Phe Met Thr 
     1170                1175                1180
His Pro Glu Phe Arg Ile Glu Asp Ser Glu Pro His Ile Pro Leu Ile 
 1185                1190                1195                1200
Asp Asp Thr Asp Ala Glu Asp Asp Ala Pro Thr Lys Arg Asn Ser Ser 
                 1205                1210                1215
Pro Pro Pro Ser Pro Asn Lys Asn Asn Asn Ala Val Asp Ser Gly Ile 
             1220                1225                1230
His Leu Thr Ile Glu Met Asn Lys Ser Ala Thr Ser Ser Ser Pro Gly 
         1235                1240                1245
Ser Pro Leu His Ser Leu Glu Thr Ser Leu 
     1250                1255



<210> 2605
<211> 781
<212> DNA
<213> Rattus norvegicus
<308> J05122
<400> 2605

tgtggatct  tccagaaca  cagttgcaa  cactatgtc  caatcctgg  tacccgccg  60
gggcctcac  ctggtgccc  gcctggggg  cttcatggg  gcctacttt  tgcgtggtg  120
gggcctccg  tggtatgct  gcttgcaga  accctcctg  catccgcct  gctggacac  180
cgctcccat  tggggcaca  tgtattcgg  catggggta  ggctcctac  taatctgga  240
agagctggg  ggtttcaca  aggaggcta  ggttccctt  ggtctctac  ctggtcagc  300
ggctctgaa  tgggcatgg  cccccatct  ctttggtgc  cggcagatg  gctgggctt  360
ggtggacct  atgcttgtc  gtggggtgg  aaccgccac  accctggct  ggcaccgag  420
gagcccacc  gctgcccgc  tgctgtatc  ttacctggc  tggctggcc  ttgccacca  480
gctcaacta  tatgtatgg  gtgataact  tggtcggcg  gggggctcc  ggctcacag  540
gtgaggaca  ctagccatc  ggaatgcag  cctgccagc  aggcatcat  ggttgaggt  600
atcctgctt  catgaccat  gggcctgct  gtctacctg  tcttagtcc  ggaagccac  660
aggtaggtc  aggtggtca  tgctaagtc  catgcgggg  cagttgtac  tgcttttct  720
cactgctgc  ggcgtgccc  aggagcatg  ggcctttaa  gctaaataa  gtctttaac  780
t  781



<210> 2606
<211> 169
<212> PRT
<213> Rattus norvegicus
<308> P16257
<400> 2606

Met Ser Gln Ser Trp Val Pro Ala Val Gly Leu Thr Leu Val Pro Ser 
  1               5                  10                  15
Leu Gly Gly Phe Met Gly Ala Tyr Phe Val Arg Gly Glu Gly Leu Arg 
             20                  25                  30
Trp Tyr Ala Ser Leu Gln Lys Pro Ser Trp His Pro Pro Arg Trp Thr 
         35                  40                  45
Leu Ala Pro Ile Trp Gly Thr Leu Tyr Ser Ala Met Gly Tyr Gly Ser 
     50                  55                  60
Tyr Ile Ile Trp Lys Glu Leu Gly Gly Phe Thr Glu Glu Ala Met Val 
 65                  70                  75                  80
Pro Leu Gly Leu Tyr Thr Gly Gln Leu Ala Leu Asn Trp Ala Trp Pro 
                 85                  90                  95
Pro Ile Phe Phe Gly Ala Arg Gln Met Gly Trp Ala Leu Val Asp Leu 
             100                105                110
Met Leu Val Ser Gly Val Ala Thr Ala Thr Thr Leu Ala Trp His Arg 
         115                120                125
Val Ser Pro Pro Ala Ala Arg Leu Leu Tyr Pro Tyr Leu Ala Trp Leu 
     130                135                140
Ala Phe Ala Thr Met Leu Asn Tyr Tyr Val Trp Arg Asp Asn Ser Gly 
 145                150                155                160
Arg Arg Gly Gly Ser Arg Leu Thr Glu 
                 165



<210> 2607
<211> 4057
<212> DNA
<213> Rattus norvegicus
<308> J05166
<400> 2607

aaaagagtt  ggagaagtt  ggagcggcg  gggcgcgcc  cggggtggg  accgggaaa  60
cgtcgggag  gcgcgaggg  tccggagga  caggggaga  ccggagacc  ccgggacac  120
aaatctaga  ctagcgggt  atgcctcca  cttgttgcc  tgaaagccg  agcgacagt  180
agaagggct  agatttggc  atgagcagc  cccccaggc  ccccgcctc  ggcgcagat  240
ctttgcaca  gccagagcc  gagagcctg  gccccggaa  acctgggtt  cctgagcaa  300
aggaggaag  tgaacttcg  accttaggt  tggagcggt  cgaggagat  ctccaggaa  360
ctggatcca  aggaggaga  gagccaggc  gcagctatg  ggaggaaga  tttgaatac  420
accgccagt  ctcccacca  atccatcat  cactctcca  ccacctgcc  cctgacgcc  480
gccgtcgca  gactcccca  ggcccagga  ggaaacctc  gaggcgccc  ggagcctct  540
ccactggag  gacccccac  attgaggaa  gggaggaag  tgaggatga  gtcggtgaa  600
ctgaagggt  cagagctcc  ccgcaacaa  catctcctg  ctcttcacc  tctgcagtt  660
agttttttc  ccaagagga  gaaggtaca  ataggaagg  agagagaac  agcccatct  720
cccctacac  gacgcccca  caggaagca  ctccccggg  cagcaaagg  gcacagaca  780
gaactctgg  ggaggagat  gtggccgtg  ccagcggca  ggctggagg  gacgacgga  840
gtgctgcag  gcgccccct  accaaagcc  agcctggac  tcgaagtta  aaccttcag  900
agagaaggc  aattggcag  atgacaggg  tggagcagg  cctgctgcc  agggtccct  960
ctgatgaga  tgaggctca  acgctggcc  cagctgacc  cgacctcat  aaaagtcac  1020
ggtttgagg  cgttccggg  gtacggcga  atttggtga  gaagaatgc  aaagggtct  1080
cacaggctg  ccgggaagg  cgagagcct  gccccacac  tcgggcacg  ccacgggcc  1140
cccataagc  tcatgaggt  ttcgtagag  tgaatgaat  gcagttgga  aaaaaccag  1200
agcctcagt  gcgggagac  gcccggtgg  taaaatttg  ggaggacgt  gaagaggag  1260
ctgagcgct  gggcaagcc  cacgtggca  cactgtcct  ccgcagcct  ctggagctc  1320
gcaggacac  ggcccatgg  gctgtgctc  tggacctcg  tcagcagac  ctgcctggg  1380
tggcccatc  ggtggtcga  cagatggtt  tctctgacc  gatcaaagc  gaggacaga  1440
ccaatgtgc  acgagccct  ctgctgaaa  acagccacc  aagtgatga  aaagaattc  1500
ccttccccc  gaacatctc  gcgggctct  tgggctctc  cctggggca  caccacgcc  1560
aggggactg  gagtgatcc  cacgtcact  agcctctca  cggtggtgt  cctgagacc  1620
ggctggagg  ggatagaga  cgtgagctg  cgcccccag  cccacctgc  ggtattacc  1680
gctccaagt  caagcatga  ctgaagctg  tggagaaga  ccctgagaa  gcagaggcc  1740
cagtggtcc  cgtgggctg  gtggagttc  tctcccgcc  caccatggc  tttgtgcgc  1800
tgcgggagg  tgtggaact  gatgcagta  tggaggtgc  tgtgcctgt  cgcttcctc  1860
tcctgctgc  ggggcccag  agcgccaac  tggactacc  tgagattgg  cgatccatc  1920
ccaccctca  gtctgacaa  caattccac  aggcagcct  cctggcaga  gaacgggat  1980
acttgctga  tgctatcaa  gccttcctg  actgcagtg  tgtgctacc  ccttctgaa  2040
tgcagggcg  ggagctgct  cgttctgtt  cccatttcc  gcgccagat  ctaaagaag  2100
gagaggagc  gggccgcct  ctgccccct  gtgctgggc  agagcccaa  tctgcccaa  2160
ataaggcac  cctgcagat  gtagaggtg  caggtgcag  tgaagatga  ccccttcgg  2220
ggacaggcc  gccctttgg  gggctgatc  gtgacgtgc  gcggcgcta  ccgcactac  2280
tgagtgact  ccgagatgc  ctagacccc  agtgcctgg  tgctgtcat  ttcatctac  2340
ttgccgccc  gtcgcctgc  atcactttt  gggggctac  gggggagaa  acacaggac  2400
tgataggag  gtcagagct  atcatgtcc  cagcgctcc  gggagtgat  ttctgcctg  2460
tgggcgccc  gccactgct  gtgatcggc  tctcggggc  tctgctggt  ttcgaggag  2520
ccttcttct  gttctgcaa  agcaaccag  tggagtact  ggtgggccg  gtttggatt  2580
gcttctggc  ggtgctcct  gccctgctc  tggtggctc  ggaggggag  ttcctggtc  2640
gctttgtct  ccgattcac  caggagatc  ttgccttcc  catatcact  atcttcatc  2700
atgagacct  ctataagct  atcaagatc  ttcaggagc  ccccctcca  ggctgctca  2760
tctccaacg  ctcagaggc  gacagcagc  gtaacaata  gacttgggc  gcaaccaca  2820
tggcaccag  caacagcag  gcgtctggg  aggagaggc  ccggggcca  cctaacact  2880
ccttgctat  actggtgct  atggccggc  ctttcttca  cgccttctt  ctgcgcaaa  2940
tcaagaaca  ccggttctt  cctggccgg  tccggcggg  aattgggga  tttggggtg  3000
ccatcgcga  cctcatcat  gtgcttgtg  attacagta  tgaggatac  tacacccag  3060
agctaagtg  gcccagtgg  ttctcagtg  cagccccag  caagcgggg  tgggtcatc  3120
acccccttg  agagaagac  cctttccct  tgtggatga  ggtggccag  ctgttgcct  3180
ccgttctgg  gttcatcct  atcttcatg  agacacaga  caccacgtt  atcatctcc  3240
agaaagagc  gatgcttca  aagggctct  gcttccacc  tgatctgtt  ctcattgta  3300
ccatgggtg  catctgtgc  ctctttggc  tgccttggt  ggctgctgc  actgtccgc  3360
ctgtcactc  tgccaatgc  ctcactgtc  tgagcaagg  tgtggcacc  ggtgacaaa  3420
ccaagattc  ggaagtcaa  gagcagcgg  tgaccgggc  gctggtggc  ctgcttgtg  3480
gactctcca  ggtcattgg  gacctactg  ggcagatcc  cctggctgt  ctctttggc  3540
ttttcttat  catgggagt  acttccctt  atgggatcc  attctacga  cggttgcac  3600
tgctactca  gccgcccaa  caccaccca  atgttacct  tgtcaagaa  gttcggacc  3660
tgcggatgc  cctgttcac  gccttgcag  tgctctgtc  ggccctgct  tgggcggtc  3720
tgtccacag  tgcttccct  gccttcccc  tcatcctca  cctcacagt  cctttgcgc  3780
tggtggtac  tacccggat  ttcactgag  gagaaatga  atgtctgga  gctaatgag  3840
cagagccag  gtttgatga  tgtgaaggt  tggacgagt  caacgagat  cccatgcct  3900
tgtagctgc  gtccagagg  atagcagag  gactaaggg  caggggctg  ggggctggg  3960
agctggggc  cccctcctc  tgtccctcc  catttttat  taagtgaat  atttaaagc  4020
cccttgtcc  caccctgca  taaagtgct  caacccc  4057



<210> 2608
<211> 1234
<212> PRT
<213> Rattus norvegicus
<308> P23347
<400> 2608

Met Ser Ser Ala Pro Arg Arg Pro Ala Ser Gly Ala Asp Ser Leu His 
  1               5                  10                  15
Thr Pro Glu Pro Glu Ser Leu Ser Pro Gly Thr Pro Gly Phe Pro Glu 
             20                  25                  30
Gln Glu Glu Glu Asp Glu Leu Arg Thr Leu Gly Val Glu Arg Phe Glu 
         35                  40                  45
Glu Ile Leu Gln Glu Ala Gly Ser Arg Gly Gly Glu Glu Pro Gly Arg 
     50                  55                  60
Ser Tyr Gly Glu Glu Asp Phe Glu Tyr His Arg Gln Ser Ser His His 
 65                  70                  75                  80
Ile His His Pro Leu Ser Thr His Leu Pro Pro Asp Ala Arg Arg Arg 
                 85                  90                  95
Lys Thr Pro Gln Gly Pro Gly Arg Lys Pro Arg Arg Arg Pro Gly Ala 
             100                105                110
Ser Pro Thr Gly Glu Thr Pro Thr Ile Glu Glu Gly Glu Glu Asp Glu 
         115                120                125
Asp Glu Val Gly Glu Ala Glu Gly Phe Arg Ala Pro Pro Gln Gln Pro 
     130                135                140
Ser Pro Ala Ser Ser Pro Ser Ala Val Gln Phe Phe Leu Gln Glu Asp 
 145                150                155                160
Glu Gly Thr Asp Arg Lys Ala Glu Arg Thr Ser Pro Ser Pro Pro Thr 
                 165                170                175
Gln Thr Pro His Gln Glu Ala Ala Pro Arg Ala Ser Lys Gly Ala Gln 
             180                185                190
Thr Gly Thr Leu Val Glu Glu Met Val Ala Val Ala Ser Gly Thr Ala 
         195                200                205
Gly Gly Asp Asp Gly Gly Ala Ala Gly Arg Pro Leu Thr Lys Ala Gln 
     210                215                220
Pro Gly His Arg Ser Tyr Asn Leu Gln Glu Arg Arg Arg Ile Gly Ser 
 225                230                235                240
Met Thr Gly Val Glu Gln Ala Leu Leu Pro Arg Val Pro Thr Asp Glu 
                 245                250                255
Ser Glu Ala Gln Thr Leu Ala Thr Ala Asp Leu Asp Leu Met Lys Ser 
             260                265                270
His Arg Phe Glu Asp Val Pro Gly Val Arg Arg His Leu Val Arg Lys 
         275                280                285
Asn Ala Lys Gly Ser Thr Gln Ala Ala Arg Glu Gly Arg Glu Pro Gly 
     290                295                300
Pro Thr Pro Arg Ala Arg Pro Arg Ala Pro His Lys Pro His Glu Val 
 305                310                315                320
Phe Val Glu Leu Asn Glu Leu Gln Leu Asp Lys Asn Gln Glu Pro Gln 
                 325                330                335
Trp Arg Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Asp Val Glu Glu 
             340                345                350
Glu Thr Glu Arg Trp Gly Lys Pro His Val Ala Ser Leu Ser Phe Arg 
         355                360                365
Ser Leu Leu Glu Leu Arg Arg Thr Leu Ala His Gly Ala Val Leu Leu 
     370                375                380
Asp Leu Asp Gln Gln Thr Leu Pro Gly Val Ala His Gln Val Val Glu 
 385                390                395                400
Gln Met Val Ile Ser Asp Gln Ile Lys Ala Glu Asp Arg Ala Asn Val 
                 405                410                415
Leu Arg Ala Leu Leu Leu Lys His Ser His Pro Ser Asp Glu Lys Glu 
             420                425                430
Phe Ser Phe Pro Arg Asn Ile Ser Ala Gly Ser Leu Gly Ser Leu Leu 
         435                440                445
Gly His His His Ala Gln Gly Thr Glu Ser Asp Pro His Val Thr Glu 
     450                455                460
Pro Leu Ile Gly Gly Val Pro Glu Thr Arg Leu Glu Val Asp Arg Glu 
 465                470                475                480
Arg Glu Leu Pro Pro Pro Ala Pro Pro Ala Gly Ile Thr Arg Ser Lys 
                 485                490                495
Ser Lys His Glu Leu Lys Leu Leu Glu Lys Ile Pro Glu Asn Ala Glu 
             500                505                510
Ala Thr Val Val Leu Val Gly Cys Val Glu Phe Leu Ser Arg Pro Thr 
         515                520                525
Met Ala Phe Val Arg Leu Arg Glu Ala Val Glu Leu Asp Ala Val Leu 
     530                535                540
Glu Val Pro Val Pro Val Arg Phe Leu Phe Leu Leu Leu Gly Pro Ser 
 545                550                555                560
Ser Ala Asn Met Asp Tyr His Glu Ile Gly Arg Ser Ile Ser Thr Leu 
                 565                570                575
Met Ser Asp Lys Gln Phe His Glu Ala Ala Tyr Leu Ala Asp Glu Arg 
             580                585                590
Asp Asp Leu Leu Thr Ala Ile Asn Ala Phe Leu Asp Cys Ser Val Val 
         595                600                605
Leu Pro Pro Ser Glu Val Gln Gly Glu Glu Leu Leu Arg Ser Val Ala 
     610                615                620
His Phe Gln Arg Gln Met Leu Lys Lys Arg Glu Glu Gln Gly Arg Leu 
 625                630                635                640
Leu Pro Pro Gly Ala Gly Leu Glu Pro Lys Ser Ala Gln Asp Lys Ala 
                 645                650                655
Leu Leu Gln Met Val Glu Val Ala Gly Ala Ala Glu Asp Asp Pro Leu 
             660                665                670
Arg Arg Thr Gly Arg Pro Phe Gly Gly Leu Ile Arg Asp Val Arg Arg 
         675                680                685
Arg Tyr Pro His Tyr Leu Ser Asp Phe Arg Asp Ala Leu Asp Pro Gln 
     690                695                700
Cys Leu Ala Ala Val Ile Phe Ile Tyr Phe Ala Ala Leu Ser Pro Ala 
 705                710                715                720
Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Gln Asp Leu Ile Gly 
                 725                730                735
Val Ser Glu Leu Ile Met Ser Thr Ala Leu Gln Gly Val Ile Phe Cys 
             740                745                750
Leu Leu Gly Ala Gln Pro Leu Leu Val Ile Gly Phe Ser Gly Pro Leu 
         755                760                765
Leu Val Phe Glu Glu Ala Phe Phe Ser Phe Cys Lys Ser Asn Gln Leu 
     770                775                780
Glu Tyr Leu Val Gly Arg Val Trp Ile Gly Phe Trp Leu Val Leu Leu 
 785                790                795                800
Ala Leu Leu Met Val Ala Leu Glu Gly Ser Phe Leu Val Arg Phe Val 
                 805                810                815
Ser Arg Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser Leu Ile Phe 
             820                825                830
Ile Tyr Glu Thr Phe Tyr Lys Leu Ile Lys Ile Phe Gln Glu His Pro 
         835                840                845
Leu His Gly Cys Ser Val Ser Asn Asp Ser Glu Ala Asp Ser Ser Ser 
     850                855                860
Asn Asn Met Thr Trp Ala Ala Thr Thr Leu Ala Pro Asp Asn Ser Ser 
 865                870                875                880
Ala Ser Gly Gln Glu Arg Pro Arg Gly Gln Pro Asn Thr Ala Leu Leu 
                 885                890                895
Ser Leu Val Leu Met Ala Gly Thr Phe Phe Ile Ala Phe Phe Leu Arg 
             900                905                910
Lys Phe Lys Asn Ser Arg Phe Phe Pro Gly Arg Ile Arg Arg Val Ile 
         915                920                925
Gly Asp Phe Gly Val Pro Ile Ala Ile Leu Ile Met Val Leu Val Asp 
     930                935                940
Tyr Ser Ile Glu Asp Thr Tyr Thr Gln Lys Leu Ser Val Pro Ser Gly 
 945                950                955                960
Phe Ser Val Thr Ala Pro Asp Lys Arg Gly Trp Val Ile Asn Pro Leu 
                 965                970                975
Gly Glu Lys Thr Pro Phe Pro Val Trp Met Met Val Ala Ser Leu Leu 
             980                985                990
Pro Ala Val Leu Val Phe Ile Leu Ile Phe Met Glu Thr Gln Ile Thr 
         995                1000                1005
Thr Leu Ile Ile Ser Lys Lys Glu Arg Met Leu Gln Lys Gly Ser Gly 
     1010                1015                1020
Phe His Leu Asp Leu Leu Leu Ile Val Ala Met Gly Gly Ile Cys Ala 
 1025                1030                1035                1040
Leu Phe Gly Leu Pro Trp Leu Ala Ala Ala Thr Val Arg Ser Val Thr 
                 1045                1050                1055
His Ala Asn Ala Leu Thr Val Met Ser Lys Ala Val Ala Pro Gly Asp 
             1060                1065                1070
Lys Pro Lys Ile Gln Glu Val Lys Glu Gln Arg Val Thr Gly Leu Leu 
         1075                1080                1085
Val Ala Leu Leu Val Gly Leu Ser Met Val Ile Gly Asp Leu Leu Arg 
     1090                1095                1100
Gln Ile Pro Leu Ala Val Leu Phe Gly Ile Phe Leu Tyr Met Gly Val 
 1105                1110                1115                1120
Thr Ser Leu Asn Gly Ile Gln Phe Tyr Glu Arg Leu His Leu Leu Leu 
                 1125                1130                1135
Met Pro Pro Lys His His Pro Asp Val Thr Tyr Val Lys Lys Val Arg 
             1140                1145                1150
Thr Met Arg Met His Leu Phe Thr Ala Leu Gln Leu Leu Cys Leu Ala 
         1155                1160                1165
Leu Leu Trp Ala Val Met Ser Thr Ala Ala Ser Leu Ala Phe Pro Phe 
     1170                1175                1180
Ile Leu Ile Leu Thr Val Pro Leu Arg Met Val Val Leu Thr Arg Ile 
 1185                1190                1195                1200
Phe Thr Glu Arg Glu Met Lys Cys Leu Asp Ala Asn Glu Ala Glu Pro 
                 1205                1210                1215
Val Phe Asp Glu Cys Glu Gly Val Asp Glu Tyr Asn Glu Met Pro Met 
             1220                1225                1230
Pro Val 
         1235



<210> 2609
<211> 8277
<212> DNA
<213> Homo sapiens
<308> U76667
<400> 2609

gtaggcgga  aggtggtgg  gggggacgg  cagggccgc  gagggagga  gggaggggg  60
aggagaggg  ggaactcgg  actcgagcg  ggagggagt  gaagtggag  aaagggcgg  120
gactggggc  cggggaacc  cggtcttgg  gagaaggat  gggaggcgg  tggagtgct  180
gtcggaagc  ggcattccg  ggtcccctt  tcagagttc  ctaaagcca  ggtgccgcg  240
cccctgcca  caggagggg  tagtctccc  gaggcgccg  cggccctcc  actccccgg  300
tggctccag  ccacccctc  cctccggcc  ccccgcata  tccttcagt  ccgtccggg  360
cgcccagac  gggggttgc  cggggcccc  atccccaat  tccgggttg  gaggcgaag  420
caggaaagg  gggtggcgg  taaggtcgg  acaaggggt  agacagaag  gggagcagc  480
gggtgggaa  gggaaagat  agcccggag  gttggacct  actcccggg  tcggtttgt  540
caggcgggg  gttctgtgc  gggtgtgag  ggcggcact  cctgaaacc  agggtctac  600
ttatccccc  tcgtttccc  cgccagccc  acatggaag  gctgcggaa  ttacgagtt  660
acttggggg  tggttaatg  ccaagtggg  gtccgaggt  ctaatccct  ggtcaaggg  720
agagatact  atcctctgg  ccggtcggg  ctggtcccg  gaatgtgcc  ctacccgga  780
tatcggcac  gatgctctg  acagaagct  ctttgtgtt  tgggacagc  ggggagggg  840
tgcagagga  tgtggagga  cgcgacgag  gcacagcct  aggtgggag  gggcgcctg  900
aggtgctct  ggcggactc  ccccacacc  ttcccagac  gggtgcact  acgctcacc  960
acaccaccc  ccctggctg  aggcctgct  agggggagg  gaagagcgt  gttagccaa  1020
ttggagtgc  tgccaagaa  gtgttgcca  gctccccat  ctgggtgac  cccccagac  1080
tatattgtt  gacgctaca  tgacttgtc  tactcctaa  tcaggcacc  ccagtcccc  1140
gcaacacac  gggagcatg  gttgctggg  accgtcact  tttgccagt  ttgggtgcc  1200
cctgtgctg  cccgctagg  atgcgcccc  tatttgcag  gattgggct  cctcctgca  1260
ctccttctc  gcccccacc  cacagtgtc  tccccagac  ccctacagt  acagtcagg  1320
gggtggcag  actgccact  agattttcc  ggctccagg  tctagaggg  cgggatcca  1380
actgcccct  agaggcaga  cctcaaggt  gcggtgccc  ccccctccc  gcccatcac  1440
tgcccctcc  ccattataa  gctctgccc  gcccatgcc  accttctgt  ccttcctct  1500
tctcagtga  tgagtggag  tgagctcct  ccctccacc  agccagcct  cttccctcc  1560
gccggtccc  aaggacctg  gggagggaa  cctcctgcc  gcctgtact  gggaggggg  1620
accccctcc  tgcaggggc  tcttgggct  tctccagag  tcttccatt  gtctgcttc  1680
tgtctcggc  gcccggccc  ggctccacg  ggtgtctca  cctccccac  acaccctct  1740
tggtctcag  cacctctgg  gggtgccct  accctgcga  gctccgttg  ctgcctggg  1800
cttcactcc  ctctttccc  agctcatta  cactccctc  ctcatcttt  ttgctttct  1860
tccgggcct  ggccttgac  cctttctcc  tcatttttc  tgcggcctt  cccacctcc  1920
ctctcctcc  ccctctact  agcctctcg  cccttttcg  cccccctcg  ctcagtcct  1980
tcctgtctc  ttgttcttc  cttttcttc  tataaataa  tctcctctg  gctgtggct  2040
ccgctaagg  ccactctga  gcccttcat  ctccaggag  atccccagc  gcgcagcct  2100
cgcgtggtg  ctcctgccc  cccagggct  tcgatggtg  tcaggcctc  cccccatcc  2160
ggttatgcc  ccgcctcgt  gccctgaaa  ccgcagcga  agcgaaaag  gctaagatt  2220
ggccatgag  agcgcccct  ggcgccccg  caagggcgc  gattctttc  gtacggtga  2280
tgtggcccc  aggtcgcca  cccaacctt  cctccctgg  cagccttgg  tgctccggc  2340
aagggtcct  gccaaccag  ggtgtgagc  tggagactg  gaggatgct  ccatcccta  2400
cctgacttt  catgatggt  gtagggggg  atgggtagt  ggggtatca  acgtcttcc  2460
gtcctgggg  gggagttga  gctgttacc  gaagaccta  gtagcttag  ctcagcggt  2520
gaggaactt  gagaaccct  ggtctctca  ccagcaacc  gtctcagac  cggctggcc  2580
tagaggcgc  ggtcaagtc  gcacgcggg  cagggttct  ggcggagct  gcctgccac  2640
actggccac  ccccctgcc  acgtgccac  caggcccgc  cctccctgc  cccacgtgg  2700
caccgctcc  catggcccc  tttggattt  cctaaggag  cttaatgat  aaccccgtg  2760
cacaatcag  tccgctatt  gtcacactg  cccagaggg  cacgtgact  ggaaggggc  2820
caggctggt  ccctccccc  ccttctcag  ttcacccct  ccggccatg  acttcctcc  2880
gcggcctca  gtgcgaggg  tctgcgacc  tctctcccc  tggcggcaa  ctccctgcg  2940
ctctccccg  cccctcgtc  cacggggct  cttctggtg  gagtggggc  gggcgctta  3000
gggagccag  agatggaca  gagccttcc  cacagaggg  agaagccag  cccctggcc  3060
gctcacctt  tcttatccg  tgttctgcc  gtcccagct  ctccagtcc  cacctcgcc  3120
ctaagaccc  cccttcacc  cagccctcc  cgcgctctt  cttgttctg  ctgctggca  3180
cgctatgga  ggggctgca  acccccgcc  ttggagatc  cgatgccct  caggtccag  3240
agctcttga  caaatattt  gcggcgcct  gagctgaga  cgtgggtgg  tggggggct  3300
gaccaaggc  gcctggcca  gcggctgcc  cttagctgg  ctgagctct  acaagcgcc  3360
cattccctg  cggctgtgc  ggccggccg  tgctccgcg  ccgcaggat  actcaggtg  3420
gggctgtgg  ggtggggtg  ggggtgggg  tagggacct  gcccagggc  cgggccggg  3480
gcctggggg  tgggggagc  ctcctgggg  ctgaagggc  tccattccg  tccctgcgg  3540
gctgggttt  tttgactcg  acaggctct  ggtcggtta  cttggcgcc  ccagaagtt  3600
ctttttggg  tcagcagtt  tcctcaggc  aactggagt  tcttcacta  ctgtcatgt  3660
aacttcccg  ttcacacgc  ctccctcca  gctgcagat  ggctggaca  acgggattt  3720
ttccacctg  cctgaactg  ctacacagc  aagggggct  ggctgggat  agggtagct  3780
agaacccag  ggacagctg  tggggggac  gggtctctg  atctgaggg  gcagactgc  3840
ggggggaca  tgggtcact  tgtttgaag  gatgtctac  ggtagggtg  ctggcttcc  3900
gcatttgag  gggcagact  cttgggagg  ctgggtccc  atatttgtt  ccttttttt  3960
tgtttttgt  ttgagacgg  gtctcactc  gtcacccag  ctggagtgc  gtggcacga  4020
cttggctca  tgcaacctc  gcctcccag  ttcaagtaa  tctcctgcc  cagcctcct  4080
agtagctgg  attactggt  tccgccacc  cgcctggct  atttttgtg  ttttagtag  4140
gatggggtt  caccatgtt  gtcaggctg  tcttgaact  ctgacctcc  gcaatccac  4200
cacctcagc  tcccaaagt  ctgggatta  aggtgtgag  cactgtgcc  ggcctgggt  4260
cctatattt  agggacagc  gctgggggg  tatagagcc  ccagcatta  aggagatag  4320
tgctggcgg  ggagggttc  tgggtctct  gcactggga  gggtgaggt  tcggggtac  4380
attcccagt  agccctgtg  gttttctct  tgccttctt  ctcacagcc  gagccagag  4440
gcttgggcc  tgggacgcc  gggttcccc  agcaggagg  agacgaact  caccgcacc  4500
tgggcgtgg  gcggtttga  gagatccta  aggaggccg  gtctcgtgg  ggggaggag  4560
caggccgca  ctatgggga  gaagacttt  agtgtgagg  ggcaggcag  ggaggggga  4620
gtgggggga  caggtttga  tgtccagca  agaagggac  ggggtccta  tgggaggag  4680
ggggctagg  ggcaggatg  caggggagg  acactgtgc  tgccacagc  aagtccccc  4740
cctccctgc  gaccaccgc  agtcctccc  ccacatcca  cacccactg  ccacccacc  4800
gcctccgga  gcacgccgc  gcaagacac  ccagggccc  ggacggaag  ctcgaaggc  4860
cccgggagc  tccccgact  gagaaaccc  gaccattga  gagggggag  aagatgagg  4920
tgaggccag  gaggctgag  gggcccggg  tctcactca  ccgtcccct  tctccacac  4980
ctcctcggt  caggtgcgc  gggtgcggg  tcctaggga  tgtcggcag  gccctggcc  5040
ggtcactcc  gcccatgtg  gtccctgtt  cagttcttt  tccaagagg  tgacagtgc  5100
gaccggaag  cagagagga  cagtccatc  tcccctgca  cactgcccc  ccaggaggc  5160
actcctcgg  cctccaaag  ggcccaggc  gggtaagta  accccaatc  acagtgtcc  5220
caacagaca  ttcccctgc  aggatagtg  ggtgatgct  gaacaaagc  tgagccttg  5280
aatcaccag  ccagggttc  aatcccagg  ccgcactca  tggctgggc  agtaactta  5340
ttaagctct  caagcccca  gttcctcat  agaaaccaa  cataacaga  cgtttctca  5400
tgggcggct  tagggatta  gggtggtgt  aattaaagt  ctaagtatg  tttagcctg  5460
cagagaaca  gcgctgcct  agctgcctc  cacccctga  ccgtctccc  cccctgcct  5520
tggtgtagt  ggagcaata  ccagcactg  ctcaggtac  ggactggtg  cctcccagc  5580
cttgctgga  gccccaggg  tcaagaggc  aaggagacc  cctctcctt  gggcactgc  5640
aacacacgc  ggttggaaa  cagatgtta  catgtgaga  ggcatcagc  tgttgtcac  5700
gcacccagt  gctggttca  gcaaagtgt  agtaccagt  gatgattgg  atttggggg  5760
aggcttcct  gagaaaatg  ctttgaact  ggtctcaag  tcactacta  cacggacct  5820
ttgttttct  ggtgccagg  agcgtgaag  gctgcggga  gtgaagggc  tgttgtccc  5880
tctgggagc  cataacctg  tgggaccgt  gcacagatg  gggcggcgg  ttacagcgg  5940
cttaggggc  ccaggatgg  agggaggag  ctggggctt  cgagaaagc  tggcatcag  6000
aaagggtcg  atttgtggg  cagggcacg  gggggctag  agagcctgg  catgggagg  6060
gactctgat  ttgagtcag  gcttggagc  ctgggggcc  ttgatgttg  gagagaggg  6120
taggaccac  tggcagggc  ctggccacc  agtgtggca  agagaaggg  gagagcaga  6180
gctggcgtc  gtgaagcct  aggcttacc  ctcctccca  ggcaggaag  tgtctgcca  6240
ctccaaggc  cggtgccac  gactttatt  ctcttgatt  aacataggc  cctgtgaac  6300
tctgagtcc  atgtctagg  atgtgccag  gggtgaggg  gcaggggga  gaatgctga  6360
tgtcaggaa  cagcgtcct  agctccttt  ctgcaccag  acctgcact  ggacttttc  6420
aaaatctca  ccctcatgg  accgcaaag  ctggtctca  ccctggctg  tgaggagca  6480
ttgacgttc  cagtggccg  tcagagggg  ctcggggtg  ccgtttggg  ctgcacagc  6540
agaaaaggg  ggagcttgg  gttcggatg  tggcagtct  catccagaa  cctccccgt  6600
cccgtgccc  cacctcccg  gagtgggag  taggagggc  tggagtccg  tgtgggtcc  6660
ctccccacc  cctgcgtgg  tgctgggcg  cggggagga  gccaggttt  tcgggctca  6720
ggccattct  tctgcctag  acccaggtg  aggaggcgg  ggcggaggc  gtggcggtg  6780
ccagtggca  agcaggggg  gacgacggg  gtgcctcgg  gcgccccct  cccaaagcc  6840
agcctgggc  ccgcagcta  aaccttcag  agaggaggc  catcgggag  atgactggg  6900
ctgagcagg  actgctgcc  cgggtcccc  cggatgaga  tgaggccca  acgctggcc  6960
cggccgacc  agacctcat  aagagtaag  gctgggcct  ggccaagcc  ggcactggt  7020
ggcaaagga  tgagagaaa  ggggagccc  accttggtc  tctgccccc  caggtcacc  7080
gtttgagga  gttcctggg  tgcggcggc  cttggtgcg  aagaatgcc  aaggttcca  7140
acagagtgg  cgagaaggg  gggagcctg  ccccacacc  cgggcccga  cccgggccc  7200
ccacaagcc  catgaggta  catgctctg  ttcatgctc  tccatcaac  tcccacacg  7260
ccctgcccc  acctctcag  ccagctgta  tctcaagcc  cagggttgc  actgttgtt  7320
tgttgttgt  tgagacagt  tcgctctgt  gcccaggat  gagtgcagt  gtgtgatct  7380
agctcactg  aacctctgc  tcctgggtt  aagcgattc  cctgcctca  cctcctgag  7440
agctgggat  acaggcacc  gctacgccc  gctaatttt  gtattttta  tagagatgc  7500
gttttacca  gttggccag  ctgttctcc  actcctagc  tctaggaat  cgcccgcct  7560
ggcctccca  agtgctggg  ttacaggca  gagctgccg  gccgggccc  gggatgcca  7620
ctttggttg  gaaggttgt  cactgcaca  gagtgcagt  tacacatct  agagcttat  7680
gacttgggc  ctgtgatta  cctccccat  gtggatgtc  ttgatttga  tattgtggt  7740
ataattcac  tctgttaaa  ggcctgcaa  acgccattg  tttcatata  agtggccat  7800
tctcaagtg  tcactctga  gcacgtagc  tgccatgtg  ttttccttt  catccttct  7860
acagttctt  gaggtgggt  ttattccca  ttgacagat  agggaaact  cgtctcatt  7920
gttagtcag  tgtccaggg  cccagctgg  tgtgggact  gtgcgcctg  gcaccaccc  7980
ctgtgctcg  gctctccag  gtcacttgg  tccctctga  accactcac  tgtgacacc  8040
accccaggg  tcgctccgg  tctgtaccc  gaaatgcct  ctcttctct  cccaaggtg  8100
ttgtggagc  gaatgagtt  ctcctggac  aaaaccagg  gccccagtg  cgggagaca  8160
ctcgctgga  caaatttga  gaggacgtg  aggaggaga  cgagcgctg  gggaagccc  8220
acgtggcct  cctctcctt  cgcagtctc  tggagctcc  caggaccct  gcccatg  8277



<210> 2610
<211> 1241
<212> PRT
<213> Homo sapiens
<308> AAF19583
<400> 2610

Met Ser Ser Ala Pro Arg Arg Pro Ala Lys Gly Ala Asp Ser Phe Cys 
  1               5                  10                  15
Thr Pro Glu Pro Glu Ser Leu Gly Pro Gly Thr Pro Gly Phe Pro Glu 
             20                  25                  30
Gln Glu Glu Asp Glu Leu His Arg Thr Leu Gly Val Glu Arg Phe Glu 
         35                  40                  45
Glu Ile Leu Gln Glu Ala Gly Ser Arg Gly Gly Glu Glu Pro Gly Arg 
     50                  55                  60
Ser Tyr Gly Glu Glu Asp Phe Glu Tyr His Arg Gln Ser Ser His His 
 65                  70                  75                  80
Ile His His Pro Leu Ser Thr His Leu Pro Pro Asp Ala Arg Arg Arg 
                 85                  90                  95
Lys Thr Pro Gln Gly Pro Gly Arg Lys Pro Arg Arg Arg Pro Gly Ala 
             100                105                110
Ser Pro Thr Gly Glu Thr Pro Thr Ile Glu Glu Gly Glu Glu Asp Glu 
         115                120                125
Asp Glu Ala Ser Glu Ala Glu Gly Ala Arg Ala Leu Thr Gln Pro Ser 
     130                135                140
Pro Val Ser Thr Pro Ser Ser Val Gln Phe Phe Leu Gln Glu Asp Asp 
 145                150                155                160
Ser Ala Asp Arg Lys Ala Glu Arg Thr Ser Pro Ser Ser Pro Ala Pro 
                 165                170                175
Leu Pro His Gln Glu Ala Thr Pro Arg Ala Ser Lys Gly Ala Gln Ala 
             180                185                190
Gly Thr Gln Val Glu Glu Ala Glu Ala Glu Ala Val Ala Val Ala Ser 
         195                200                205
Gly Thr Ala Gly Gly Asp Asp Gly Gly Ala Ser Gly Arg Pro Leu Pro 
     210                215                220
Lys Ala Gln Pro Gly His Arg Ser Tyr Asn Leu Gln Glu Arg Arg Arg 
 225                230                235                240
Ile Gly Ser Met Thr Gly Ala Glu Gln Ala Leu Leu Pro Arg Val Pro 
                 245                250                255
Thr Asp Glu Ile Glu Ala Gln Thr Leu Ala Thr Ala Asp Leu Asp Leu 
             260                265                270
Met Lys Ser His Arg Phe Glu Asp Val Pro Gly Val Arg Arg His Leu 
         275                280                285
Val Arg Lys Asn Ala Lys Gly Ser Thr Gln Ser Gly Arg Glu Gly Arg 
     290                295                300
Glu Pro Gly Pro Thr Pro Arg Ala Arg Pro Arg Ala Pro His Lys Pro 
 305                310                315                320
His Glu Val Phe Val Glu Leu Asn Glu Leu Leu Leu Asp Lys Asn Gln 
                 325                330                335
Glu Pro Gln Trp Arg Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Asp 
             340                345                350
Val Glu Glu Glu Thr Glu Arg Trp Gly Lys Pro His Val Ala Ser Leu 
         355                360                365
Ser Phe Arg Ser Leu Leu Glu Leu Arg Arg Thr Leu Ala His Gly Ala 
     370                375                380
Val Leu Leu Asp Leu Asp Gln Gln Thr Leu Pro Gly Val Ala His Gln 
 385                390                395                400
Val Val Glu Gln Met Val Ile Ser Asp Gln Ile Lys Ala Glu Asp Arg 
                 405                410                415
Ala Asn Val Leu Arg Ala Leu Leu Leu Lys His Ser His Pro Ser Asp 
             420                425                430
Glu Lys Asp Phe Ser Phe Pro Arg Asn Ile Ser Ala Gly Ser Leu Gly 
         435                440                445
Ser Leu Leu Gly His His His Gly Gln Gly Ala Glu Ser Asp Pro His 
     450                455                460
Val Thr Glu Pro Leu Met Gly Gly Val Pro Glu Thr Arg Leu Glu Val 
 465                470                475                480
Glu Arg Glu Arg Asp Val Pro Pro Pro Ala Pro Pro Ala Gly Ile Thr 
                 485                490                495
Arg Ser Lys Ser Lys His Glu Leu Lys Leu Leu Glu Lys Ile Pro Glu 
             500                505                510
Asn Ala Glu Ala Thr Val Val Leu Val Gly Cys Val Glu Phe Leu Ser 
         515                520                525
Arg Pro Thr Met Ala Phe Val Arg Leu Arg Glu Ala Val Glu Leu Asp 
     530                535                540
Ala Val Leu Glu Val Pro Val Pro Val Arg Phe Leu Phe Leu Leu Leu 
 545                550                555                560
Gly Pro Ser Ser Ala Asn Met Asp Tyr His Glu Ile Gly Arg Ser Ile 
                 565                570                575
Ser Thr Leu Met Ser Asp Lys Gln Phe His Glu Ala Ala Tyr Leu Ala 
             580                585                590
Asp Glu Arg Glu Asp Leu Leu Thr Ala Ile Asn Ala Phe Leu Asp Cys 
         595                600                605
Ser Val Val Leu Pro Pro Ser Glu Val Gln Gly Glu Glu Leu Leu Arg 
     610                615                620
Ser Val Ala His Phe Gln Arg Gln Met Leu Lys Lys Arg Glu Glu Gln 
 625                630                635                640
Gly Arg Leu Leu Pro Thr Gly Ala Gly Leu Glu Pro Lys Ser Ala Gln 
                 645                650                655
Asp Lys Ala Leu Leu Gln Met Val Glu Ala Ala Gly Ala Ala Glu Asp 
             660                665                670
Asp Pro Leu Arg Arg Thr Gly Arg Pro Phe Gly Gly Leu Ile Arg Asp 
         675                680                685
Val Arg Arg Arg Tyr Pro His Tyr Leu Ser Asp Phe Arg Asp Ala Leu 
     690                695                700
Asp Pro Gln Cys Leu Ala Ala Val Ile Phe Ile Tyr Phe Ala Ala Leu 
 705                710                715                720
Ser Pro Ala Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Gln Asp 
                 725                730                735
Leu Ile Gly Val Ser Glu Leu Ile Met Ser Thr Ala Leu Gln Gly Val 
             740                745                750
Val Phe Cys Leu Leu Gly Ala Gln Pro Leu Leu Val Ile Gly Phe Ser 
         755                760                765
Gly Pro Leu Leu Val Phe Glu Glu Ala Phe Phe Ser Phe Cys Ser Ser 
     770                775                780
Asn His Leu Glu Tyr Leu Val Gly Arg Val Trp Ile Gly Phe Trp Leu 
 785                790                795                800
Val Phe Leu Ala Leu Leu Met Val Ala Leu Glu Gly Ser Phe Leu Val 
                 805                810                815
Arg Phe Val Ser Arg Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser 
             820                825                830
Leu Ile Phe Ile Tyr Glu Thr Phe Tyr Lys Leu Val Lys Ile Phe Gln 
         835                840                845
Glu His Pro Leu His Gly Cys Ser Ala Ser Asn Ser Ser Glu Val Asp 
     850                855                860
Gly Gly Glu Asn Met Thr Trp Ala Gly Ala Arg Pro Thr Leu Gly Pro 
 865                870                875                880
Gly Asn Arg Ser Leu Ala Gly Gln Ser Gly Gln Gly Lys Pro Arg Gly 
                 885                890                895
Gln Pro Asn Thr Ala Leu Leu Ser Leu Val Leu Met Ala Gly Thr Phe 
             900                905                910
Phe Ile Ala Phe Phe Leu Arg Lys Phe Lys Asn Ser Arg Phe Phe Pro 
         915                920                925
Gly Arg Ile Arg Arg Val Ile Gly Asp Phe Gly Val Pro Ile Ala Ile 
     930                935                940
Leu Ile Met Val Leu Val Asp Tyr Ser Ile Glu Asp Thr Tyr Thr Gln 
 945                950                955                960
Lys Leu Ser Val Pro Ser Gly Phe Ser Val Thr Ala Pro Glu Lys Arg 
                 965                970                975
Gly Trp Val Ile Asn Pro Leu Gly Glu Lys Ser Pro Phe Pro Val Trp 
             980                985                990
Met Met Val Ala Ser Leu Leu Pro Ala Ile Leu Val Phe Ile Leu Ile 
         995                1000                1005
Phe Met Glu Thr Gln Ile Thr Thr Leu Ile Ile Ser Lys Lys Glu Arg 
     1010                1015                1020
Met Leu Gln Lys Gly Ser Gly Phe His Leu Asp Leu Leu Leu Ile Val 
 1025                1030                1035                1040
Ala Met Gly Gly Ile Cys Ala Leu Phe Gly Leu Pro Trp Leu Ala Ala 
                 1045                1050                1055
Ala Thr Val Arg Ser Val Thr His Ala Asn Ala Leu Thr Val Met Ser 
             1060                1065                1070
Lys Ala Val Ala Pro Gly Asp Lys Pro Lys Ile Gln Glu Val Lys Glu 
         1075                1080                1085
Gln Arg Val Thr Gly Leu Leu Val Ala Leu Leu Val Gly Leu Ser Ile 
     1090                1095                1100
Val Ile Gly Asp Leu Leu Arg Gln Ile Pro Leu Ala Val Leu Phe Gly 
 1105                1110                1115                1120
Ile Phe Leu Tyr Met Gly Val Thr Ser Leu Asn Gly Ile Gln Phe Tyr 
                 1125                1130                1135
Glu Arg Leu His Leu Leu Leu Met Pro Pro Lys His His Pro Asp Val 
             1140                1145                1150
Thr Tyr Val Lys Lys Val Arg Thr Leu Arg Met His Leu Phe Thr Ala 
         1155                1160                1165
Leu Gln Leu Leu Cys Leu Ala Leu Leu Trp Ala Val Met Ser Thr Ala 
     1170                1175                1180
Ala Ser Leu Ala Phe Pro Phe Ile Leu Ile Leu Thr Val Pro Leu Arg 
 1185                1190                1195                1200
Met Val Val Leu Thr Arg Ile Phe Thr Asp Arg Glu Met Lys Cys Leu 
                 1205                1210                1215
Asp Ala Asn Glu Ala Glu Pro Val Phe Asp Glu Arg Glu Gly Val Asp 
             1220                1225                1230
Glu Tyr Asn Glu Met Pro Met Pro Val 
         1235                1240



<210> 2611
<211> 4057
<212> DNA
<213> Rattus norvegicus
<308> J05166
<400> 2611

aaaagagtt  ggagaagtt  ggagcggcg  gggcgcgcc  cggggtggg  accgggaaa  60
cgtcgggag  gcgcgaggg  tccggagga  caggggaga  ccggagacc  ccgggacac  120
aaatctaga  ctagcgggt  atgcctcca  cttgttgcc  tgaaagccg  agcgacagt  180
agaagggct  agatttggc  atgagcagc  cccccaggc  ccccgcctc  ggcgcagat  240
ctttgcaca  gccagagcc  gagagcctg  gccccggaa  acctgggtt  cctgagcaa  300
aggaggaag  tgaacttcg  accttaggt  tggagcggt  cgaggagat  ctccaggaa  360
ctggatcca  aggaggaga  gagccaggc  gcagctatg  ggaggaaga  tttgaatac  420
accgccagt  ctcccacca  atccatcat  cactctcca  ccacctgcc  cctgacgcc  480
gccgtcgca  gactcccca  ggcccagga  ggaaacctc  gaggcgccc  ggagcctct  540
ccactggag  gacccccac  attgaggaa  gggaggaag  tgaggatga  gtcggtgaa  600
ctgaagggt  cagagctcc  ccgcaacaa  catctcctg  ctcttcacc  tctgcagtt  660
agttttttc  ccaagagga  gaaggtaca  ataggaagg  agagagaac  agcccatct  720
cccctacac  gacgcccca  caggaagca  ctccccggg  cagcaaagg  gcacagaca  780
gaactctgg  ggaggagat  gtggccgtg  ccagcggca  ggctggagg  gacgacgga  840
gtgctgcag  gcgccccct  accaaagcc  agcctggac  tcgaagtta  aaccttcag  900
agagaaggc  aattggcag  atgacaggg  tggagcagg  cctgctgcc  agggtccct  960
ctgatgaga  tgaggctca  acgctggcc  cagctgacc  cgacctcat  aaaagtcac  1020
ggtttgagg  cgttccggg  gtacggcga  atttggtga  gaagaatgc  aaagggtct  1080
cacaggctg  ccgggaagg  cgagagcct  gccccacac  tcgggcacg  ccacgggcc  1140
cccataagc  tcatgaggt  ttcgtagag  tgaatgaat  gcagttgga  aaaaaccag  1200
agcctcagt  gcgggagac  gcccggtgg  taaaatttg  ggaggacgt  gaagaggag  1260
ctgagcgct  gggcaagcc  cacgtggca  cactgtcct  ccgcagcct  ctggagctc  1320
gcaggacac  ggcccatgg  gctgtgctc  tggacctcg  tcagcagac  ctgcctggg  1380
tggcccatc  ggtggtcga  cagatggtt  tctctgacc  gatcaaagc  gaggacaga  1440
ccaatgtgc  acgagccct  ctgctgaaa  acagccacc  aagtgatga  aaagaattc  1500
ccttccccc  gaacatctc  gcgggctct  tgggctctc  cctggggca  caccacgcc  1560
aggggactg  gagtgatcc  cacgtcact  agcctctca  cggtggtgt  cctgagacc  1620
ggctggagg  ggatagaga  cgtgagctg  cgcccccag  cccacctgc  ggtattacc  1680
gctccaagt  caagcatga  ctgaagctg  tggagaaga  ccctgagaa  gcagaggcc  1740
cagtggtcc  cgtgggctg  gtggagttc  tctcccgcc  caccatggc  tttgtgcgc  1800
tgcgggagg  tgtggaact  gatgcagta  tggaggtgc  tgtgcctgt  cgcttcctc  1860
tcctgctgc  ggggcccag  agcgccaac  tggactacc  tgagattgg  cgatccatc  1920
ccaccctca  gtctgacaa  caattccac  aggcagcct  cctggcaga  gaacgggat  1980
acttgctga  tgctatcaa  gccttcctg  actgcagtg  tgtgctacc  ccttctgaa  2040
tgcagggcg  ggagctgct  cgttctgtt  cccatttcc  gcgccagat  ctaaagaag  2100
gagaggagc  gggccgcct  ctgccccct  gtgctgggc  agagcccaa  tctgcccaa  2160
ataaggcac  cctgcagat  gtagaggtg  caggtgcag  tgaagatga  ccccttcgg  2220
ggacaggcc  gccctttgg  gggctgatc  gtgacgtgc  gcggcgcta  ccgcactac  2280
tgagtgact  ccgagatgc  ctagacccc  agtgcctgg  tgctgtcat  ttcatctac  2340
ttgccgccc  gtcgcctgc  atcactttt  gggggctac  gggggagaa  acacaggac  2400
tgataggag  gtcagagct  atcatgtcc  cagcgctcc  gggagtgat  ttctgcctg  2460
tgggcgccc  gccactgct  gtgatcggc  tctcggggc  tctgctggt  ttcgaggag  2520
ccttcttct  gttctgcaa  agcaaccag  tggagtact  ggtgggccg  gtttggatt  2580
gcttctggc  ggtgctcct  gccctgctc  tggtggctc  ggaggggag  ttcctggtc  2640
gctttgtct  ccgattcac  caggagatc  ttgccttcc  catatcact  atcttcatc  2700
atgagacct  ctataagct  atcaagatc  ttcaggagc  ccccctcca  ggctgctca  2760
tctccaacg  ctcagaggc  gacagcagc  gtaacaata  gacttgggc  gcaaccaca  2820
tggcaccag  caacagcag  gcgtctggg  aggagaggc  ccggggcca  cctaacact  2880
ccttgctat  actggtgct  atggccggc  ctttcttca  cgccttctt  ctgcgcaaa  2940
tcaagaaca  ccggttctt  cctggccgg  tccggcggg  aattgggga  tttggggtg  3000
ccatcgcga  cctcatcat  gtgcttgtg  attacagta  tgaggatac  tacacccag  3060
agctaagtg  gcccagtgg  ttctcagtg  cagccccag  caagcgggg  tgggtcatc  3120
acccccttg  agagaagac  cctttccct  tgtggatga  ggtggccag  ctgttgcct  3180
ccgttctgg  gttcatcct  atcttcatg  agacacaga  caccacgtt  atcatctcc  3240
agaaagagc  gatgcttca  aagggctct  gcttccacc  tgatctgtt  ctcattgta  3300
ccatgggtg  catctgtgc  ctctttggc  tgccttggt  ggctgctgc  actgtccgc  3360
ctgtcactc  tgccaatgc  ctcactgtc  tgagcaagg  tgtggcacc  ggtgacaaa  3420
ccaagattc  ggaagtcaa  gagcagcgg  tgaccgggc  gctggtggc  ctgcttgtg  3480
gactctcca  ggtcattgg  gacctactg  ggcagatcc  cctggctgt  ctctttggc  3540
ttttcttat  catgggagt  acttccctt  atgggatcc  attctacga  cggttgcac  3600
tgctactca  gccgcccaa  caccaccca  atgttacct  tgtcaagaa  gttcggacc  3660
tgcggatgc  cctgttcac  gccttgcag  tgctctgtc  ggccctgct  tgggcggtc  3720
tgtccacag  tgcttccct  gccttcccc  tcatcctca  cctcacagt  cctttgcgc  3780
tggtggtac  tacccggat  ttcactgag  gagaaatga  atgtctgga  gctaatgag  3840
cagagccag  gtttgatga  tgtgaaggt  tggacgagt  caacgagat  cccatgcct  3900
tgtagctgc  gtccagagg  atagcagag  gactaaggg  caggggctg  ggggctggg  3960
agctggggc  cccctcctc  tgtccctcc  catttttat  taagtgaat  atttaaagc  4020
cccttgtcc  caccctgca  taaagtgct  caacccc  4057



<210> 2612
<211> 1234
<212> PRT
<213> Rattus norvegicus
<308> P23347
<400> 2612

Met Ser Ser Ala Pro Arg Arg Pro Ala Ser Gly Ala Asp Ser Leu His 
  1               5                  10                  15
Thr Pro Glu Pro Glu Ser Leu Ser Pro Gly Thr Pro Gly Phe Pro Glu 
             20                  25                  30
Gln Glu Glu Glu Asp Glu Leu Arg Thr Leu Gly Val Glu Arg Phe Glu 
         35                  40                  45
Glu Ile Leu Gln Glu Ala Gly Ser Arg Gly Gly Glu Glu Pro Gly Arg 
     50                  55                  60
Ser Tyr Gly Glu Glu Asp Phe Glu Tyr His Arg Gln Ser Ser His His 
 65                  70                  75                  80
Ile His His Pro Leu Ser Thr His Leu Pro Pro Asp Ala Arg Arg Arg 
                 85                  90                  95
Lys Thr Pro Gln Gly Pro Gly Arg Lys Pro Arg Arg Arg Pro Gly Ala 
             100                105                110
Ser Pro Thr Gly Glu Thr Pro Thr Ile Glu Glu Gly Glu Glu Asp Glu 
         115                120                125
Asp Glu Val Gly Glu Ala Glu Gly Phe Arg Ala Pro Pro Gln Gln Pro 
     130                135                140
Ser Pro Ala Ser Ser Pro Ser Ala Val Gln Phe Phe Leu Gln Glu Asp 
 145                150                155                160
Glu Gly Thr Asp Arg Lys Ala Glu Arg Thr Ser Pro Ser Pro Pro Thr 
                 165                170                175
Gln Thr Pro His Gln Glu Ala Ala Pro Arg Ala Ser Lys Gly Ala Gln 
             180                185                190
Thr Gly Thr Leu Val Glu Glu Met Val Ala Val Ala Ser Gly Thr Ala 
         195                200                205
Gly Gly Asp Asp Gly Gly Ala Ala Gly Arg Pro Leu Thr Lys Ala Gln 
     210                215                220
Pro Gly His Arg Ser Tyr Asn Leu Gln Glu Arg Arg Arg Ile Gly Ser 
 225                230                235                240
Met Thr Gly Val Glu Gln Ala Leu Leu Pro Arg Val Pro Thr Asp Glu 
                 245                250                255
Ser Glu Ala Gln Thr Leu Ala Thr Ala Asp Leu Asp Leu Met Lys Ser 
             260                265                270
His Arg Phe Glu Asp Val Pro Gly Val Arg Arg His Leu Val Arg Lys 
         275                280                285
Asn Ala Lys Gly Ser Thr Gln Ala Ala Arg Glu Gly Arg Glu Pro Gly 
     290                295                300
Pro Thr Pro Arg Ala Arg Pro Arg Ala Pro His Lys Pro His Glu Val 
 305                310                315                320
Phe Val Glu Leu Asn Glu Leu Gln Leu Asp Lys Asn Gln Glu Pro Gln 
                 325                330                335
Trp Arg Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Asp Val Glu Glu 
             340                345                350
Glu Thr Glu Arg Trp Gly Lys Pro His Val Ala Ser Leu Ser Phe Arg 
         355                360                365
Ser Leu Leu Glu Leu Arg Arg Thr Leu Ala His Gly Ala Val Leu Leu 
     370                375                380
Asp Leu Asp Gln Gln Thr Leu Pro Gly Val Ala His Gln Val Val Glu 
 385                390                395                400
Gln Met Val Ile Ser Asp Gln Ile Lys Ala Glu Asp Arg Ala Asn Val 
                 405                410                415
Leu Arg Ala Leu Leu Leu Lys His Ser His Pro Ser Asp Glu Lys Glu 
             420                425                430
Phe Ser Phe Pro Arg Asn Ile Ser Ala Gly Ser Leu Gly Ser Leu Leu 
         435                440                445
Gly His His His Ala Gln Gly Thr Glu Ser Asp Pro His Val Thr Glu 
     450                455                460
Pro Leu Ile Gly Gly Val Pro Glu Thr Arg Leu Glu Val Asp Arg Glu 
 465                470                475                480
Arg Glu Leu Pro Pro Pro Ala Pro Pro Ala Gly Ile Thr Arg Ser Lys 
                 485                490                495
Ser Lys His Glu Leu Lys Leu Leu Glu Lys Ile Pro Glu Asn Ala Glu 
             500                505                510
Ala Thr Val Val Leu Val Gly Cys Val Glu Phe Leu Ser Arg Pro Thr 
         515                520                525
Met Ala Phe Val Arg Leu Arg Glu Ala Val Glu Leu Asp Ala Val Leu 
     530                535                540
Glu Val Pro Val Pro Val Arg Phe Leu Phe Leu Leu Leu Gly Pro Ser 
 545                550                555                560
Ser Ala Asn Met Asp Tyr His Glu Ile Gly Arg Ser Ile Ser Thr Leu 
                 565                570                575
Met Ser Asp Lys Gln Phe His Glu Ala Ala Tyr Leu Ala Asp Glu Arg 
             580                585                590
Asp Asp Leu Leu Thr Ala Ile Asn Ala Phe Leu Asp Cys Ser Val Val 
         595                600                605
Leu Pro Pro Ser Glu Val Gln Gly Glu Glu Leu Leu Arg Ser Val Ala 
     610                615                620
His Phe Gln Arg Gln Met Leu Lys Lys Arg Glu Glu Gln Gly Arg Leu 
 625                630                635                640
Leu Pro Pro Gly Ala Gly Leu Glu Pro Lys Ser Ala Gln Asp Lys Ala 
                 645                650                655
Leu Leu Gln Met Val Glu Val Ala Gly Ala Ala Glu Asp Asp Pro Leu 
             660                665                670
Arg Arg Thr Gly Arg Pro Phe Gly Gly Leu Ile Arg Asp Val Arg Arg 
         675                680                685
Arg Tyr Pro His Tyr Leu Ser Asp Phe Arg Asp Ala Leu Asp Pro Gln 
     690                695                700
Cys Leu Ala Ala Val Ile Phe Ile Tyr Phe Ala Ala Leu Ser Pro Ala 
 705                710                715                720
Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Gln Asp Leu Ile Gly 
                 725                730                735
Val Ser Glu Leu Ile Met Ser Thr Ala Leu Gln Gly Val Ile Phe Cys 
             740                745                750
Leu Leu Gly Ala Gln Pro Leu Leu Val Ile Gly Phe Ser Gly Pro Leu 
         755                760                765
Leu Val Phe Glu Glu Ala Phe Phe Ser Phe Cys Lys Ser Asn Gln Leu 
     770                775                780
Glu Tyr Leu Val Gly Arg Val Trp Ile Gly Phe Trp Leu Val Leu Leu 
 785                790                795                800
Ala Leu Leu Met Val Ala Leu Glu Gly Ser Phe Leu Val Arg Phe Val 
                 805                810                815
Ser Arg Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser Leu Ile Phe 
             820                825                830
Ile Tyr Glu Thr Phe Tyr Lys Leu Ile Lys Ile Phe Gln Glu His Pro 
         835                840                845
Leu His Gly Cys Ser Val Ser Asn Asp Ser Glu Ala Asp Ser Ser Ser 
     850                855                860
Asn Asn Met Thr Trp Ala Ala Thr Thr Leu Ala Pro Asp Asn Ser Ser 
 865                870                875                880
Ala Ser Gly Gln Glu Arg Pro Arg Gly Gln Pro Asn Thr Ala Leu Leu 
                 885                890                895
Ser Leu Val Leu Met Ala Gly Thr Phe Phe Ile Ala Phe Phe Leu Arg 
             900                905                910
Lys Phe Lys Asn Ser Arg Phe Phe Pro Gly Arg Ile Arg Arg Val Ile 
         915                920                925
Gly Asp Phe Gly Val Pro Ile Ala Ile Leu Ile Met Val Leu Val Asp 
     930                935                940
Tyr Ser Ile Glu Asp Thr Tyr Thr Gln Lys Leu Ser Val Pro Ser Gly 
 945                950                955                960
Phe Ser Val Thr Ala Pro Asp Lys Arg Gly Trp Val Ile Asn Pro Leu 
                 965                970                975
Gly Glu Lys Thr Pro Phe Pro Val Trp Met Met Val Ala Ser Leu Leu 
             980                985                990
Pro Ala Val Leu Val Phe Ile Leu Ile Phe Met Glu Thr Gln Ile Thr 
         995                1000                1005
Thr Leu Ile Ile Ser Lys Lys Glu Arg Met Leu Gln Lys Gly Ser Gly 
     1010                1015                1020
Phe His Leu Asp Leu Leu Leu Ile Val Ala Met Gly Gly Ile Cys Ala 
 1025                1030                1035                1040
Leu Phe Gly Leu Pro Trp Leu Ala Ala Ala Thr Val Arg Ser Val Thr 
                 1045                1050                1055
His Ala Asn Ala Leu Thr Val Met Ser Lys Ala Val Ala Pro Gly Asp 
             1060                1065                1070
Lys Pro Lys Ile Gln Glu Val Lys Glu Gln Arg Val Thr Gly Leu Leu 
         1075                1080                1085
Val Ala Leu Leu Val Gly Leu Ser Met Val Ile Gly Asp Leu Leu Arg 
     1090                1095                1100
Gln Ile Pro Leu Ala Val Leu Phe Gly Ile Phe Leu Tyr Met Gly Val 
 1105                1110                1115                1120
Thr Ser Leu Asn Gly Ile Gln Phe Tyr Glu Arg Leu His Leu Leu Leu 
                 1125                1130                1135
Met Pro Pro Lys His His Pro Asp Val Thr Tyr Val Lys Lys Val Arg 
             1140                1145                1150
Thr Met Arg Met His Leu Phe Thr Ala Leu Gln Leu Leu Cys Leu Ala 
         1155                1160                1165
Leu Leu Trp Ala Val Met Ser Thr Ala Ala Ser Leu Ala Phe Pro Phe 
     1170                1175                1180
Ile Leu Ile Leu Thr Val Pro Leu Arg Met Val Val Leu Thr Arg Ile 
 1185                1190                1195                1200
Phe Thr Glu Arg Glu Met Lys Cys Leu Asp Ala Asn Glu Ala Glu Pro 
                 1205                1210                1215
Val Phe Asp Glu Cys Glu Gly Val Asp Glu Tyr Asn Glu Met Pro Met 
             1220                1225                1230
Pro Val 
         1235



<210> 2613
<211> 4057
<212> DNA
<213> Rattus norvegicus
<308> J05166
<400> 2613

aaaagagtt  ggagaagtt  ggagcggcg  gggcgcgcc  cggggtggg  accgggaaa  60
cgtcgggag  gcgcgaggg  tccggagga  caggggaga  ccggagacc  ccgggacac  120
aaatctaga  ctagcgggt  atgcctcca  cttgttgcc  tgaaagccg  agcgacagt  180
agaagggct  agatttggc  atgagcagc  cccccaggc  ccccgcctc  ggcgcagat  240
ctttgcaca  gccagagcc  gagagcctg  gccccggaa  acctgggtt  cctgagcaa  300
aggaggaag  tgaacttcg  accttaggt  tggagcggt  cgaggagat  ctccaggaa  360
ctggatcca  aggaggaga  gagccaggc  gcagctatg  ggaggaaga  tttgaatac  420
accgccagt  ctcccacca  atccatcat  cactctcca  ccacctgcc  cctgacgcc  480
gccgtcgca  gactcccca  ggcccagga  ggaaacctc  gaggcgccc  ggagcctct  540
ccactggag  gacccccac  attgaggaa  gggaggaag  tgaggatga  gtcggtgaa  600
ctgaagggt  cagagctcc  ccgcaacaa  catctcctg  ctcttcacc  tctgcagtt  660
agttttttc  ccaagagga  gaaggtaca  ataggaagg  agagagaac  agcccatct  720
cccctacac  gacgcccca  caggaagca  ctccccggg  cagcaaagg  gcacagaca  780
gaactctgg  ggaggagat  gtggccgtg  ccagcggca  ggctggagg  gacgacgga  840
gtgctgcag  gcgccccct  accaaagcc  agcctggac  tcgaagtta  aaccttcag  900
agagaaggc  aattggcag  atgacaggg  tggagcagg  cctgctgcc  agggtccct  960
ctgatgaga  tgaggctca  acgctggcc  cagctgacc  cgacctcat  aaaagtcac  1020
ggtttgagg  cgttccggg  gtacggcga  atttggtga  gaagaatgc  aaagggtct  1080
cacaggctg  ccgggaagg  cgagagcct  gccccacac  tcgggcacg  ccacgggcc  1140
cccataagc  tcatgaggt  ttcgtagag  tgaatgaat  gcagttgga  aaaaaccag  1200
agcctcagt  gcgggagac  gcccggtgg  taaaatttg  ggaggacgt  gaagaggag  1260
ctgagcgct  gggcaagcc  cacgtggca  cactgtcct  ccgcagcct  ctggagctc  1320
gcaggacac  ggcccatgg  gctgtgctc  tggacctcg  tcagcagac  ctgcctggg  1380
tggcccatc  ggtggtcga  cagatggtt  tctctgacc  gatcaaagc  gaggacaga  1440
ccaatgtgc  acgagccct  ctgctgaaa  acagccacc  aagtgatga  aaagaattc  1500
ccttccccc  gaacatctc  gcgggctct  tgggctctc  cctggggca  caccacgcc  1560
aggggactg  gagtgatcc  cacgtcact  agcctctca  cggtggtgt  cctgagacc  1620
ggctggagg  ggatagaga  cgtgagctg  cgcccccag  cccacctgc  ggtattacc  1680
gctccaagt  caagcatga  ctgaagctg  tggagaaga  ccctgagaa  gcagaggcc  1740
cagtggtcc  cgtgggctg  gtggagttc  tctcccgcc  caccatggc  tttgtgcgc  1800
tgcgggagg  tgtggaact  gatgcagta  tggaggtgc  tgtgcctgt  cgcttcctc  1860
tcctgctgc  ggggcccag  agcgccaac  tggactacc  tgagattgg  cgatccatc  1920
ccaccctca  gtctgacaa  caattccac  aggcagcct  cctggcaga  gaacgggat  1980
acttgctga  tgctatcaa  gccttcctg  actgcagtg  tgtgctacc  ccttctgaa  2040
tgcagggcg  ggagctgct  cgttctgtt  cccatttcc  gcgccagat  ctaaagaag  2100
gagaggagc  gggccgcct  ctgccccct  gtgctgggc  agagcccaa  tctgcccaa  2160
ataaggcac  cctgcagat  gtagaggtg  caggtgcag  tgaagatga  ccccttcgg  2220
ggacaggcc  gccctttgg  gggctgatc  gtgacgtgc  gcggcgcta  ccgcactac  2280
tgagtgact  ccgagatgc  ctagacccc  agtgcctgg  tgctgtcat  ttcatctac  2340
ttgccgccc  gtcgcctgc  atcactttt  gggggctac  gggggagaa  acacaggac  2400
tgataggag  gtcagagct  atcatgtcc  cagcgctcc  gggagtgat  ttctgcctg  2460
tgggcgccc  gccactgct  gtgatcggc  tctcggggc  tctgctggt  ttcgaggag  2520
ccttcttct  gttctgcaa  agcaaccag  tggagtact  ggtgggccg  gtttggatt  2580
gcttctggc  ggtgctcct  gccctgctc  tggtggctc  ggaggggag  ttcctggtc  2640
gctttgtct  ccgattcac  caggagatc  ttgccttcc  catatcact  atcttcatc  2700
atgagacct  ctataagct  atcaagatc  ttcaggagc  ccccctcca  ggctgctca  2760
tctccaacg  ctcagaggc  gacagcagc  gtaacaata  gacttgggc  gcaaccaca  2820
tggcaccag  caacagcag  gcgtctggg  aggagaggc  ccggggcca  cctaacact  2880
ccttgctat  actggtgct  atggccggc  ctttcttca  cgccttctt  ctgcgcaaa  2940
tcaagaaca  ccggttctt  cctggccgg  tccggcggg  aattgggga  tttggggtg  3000
ccatcgcga  cctcatcat  gtgcttgtg  attacagta  tgaggatac  tacacccag  3060
agctaagtg  gcccagtgg  ttctcagtg  cagccccag  caagcgggg  tgggtcatc  3120
acccccttg  agagaagac  cctttccct  tgtggatga  ggtggccag  ctgttgcct  3180
ccgttctgg  gttcatcct  atcttcatg  agacacaga  caccacgtt  atcatctcc  3240
agaaagagc  gatgcttca  aagggctct  gcttccacc  tgatctgtt  ctcattgta  3300
ccatgggtg  catctgtgc  ctctttggc  tgccttggt  ggctgctgc  actgtccgc  3360
ctgtcactc  tgccaatgc  ctcactgtc  tgagcaagg  tgtggcacc  ggtgacaaa  3420
ccaagattc  ggaagtcaa  gagcagcgg  tgaccgggc  gctggtggc  ctgcttgtg  3480
gactctcca  ggtcattgg  gacctactg  ggcagatcc  cctggctgt  ctctttggc  3540
ttttcttat  catgggagt  acttccctt  atgggatcc  attctacga  cggttgcac  3600
tgctactca  gccgcccaa  caccaccca  atgttacct  tgtcaagaa  gttcggacc  3660
tgcggatgc  cctgttcac  gccttgcag  tgctctgtc  ggccctgct  tgggcggtc  3720
tgtccacag  tgcttccct  gccttcccc  tcatcctca  cctcacagt  cctttgcgc  3780
tggtggtac  tacccggat  ttcactgag  gagaaatga  atgtctgga  gctaatgag  3840
cagagccag  gtttgatga  tgtgaaggt  tggacgagt  caacgagat  cccatgcct  3900
tgtagctgc  gtccagagg  atagcagag  gactaaggg  caggggctg  ggggctggg  3960
agctggggc  cccctcctc  tgtccctcc  catttttat  taagtgaat  atttaaagc  4020
cccttgtcc  caccctgca  taaagtgct  caacccc  4057



<210> 2614
<211> 1234
<212> PRT
<213> Rattus norvegicus
<308> P23347
<400> 2614

Met Ser Ser Ala Pro Arg Arg Pro Ala Ser Gly Ala Asp Ser Leu His 
  1               5                  10                  15
Thr Pro Glu Pro Glu Ser Leu Ser Pro Gly Thr Pro Gly Phe Pro Glu 
             20                  25                  30
Gln Glu Glu Glu Asp Glu Leu Arg Thr Leu Gly Val Glu Arg Phe Glu 
         35                  40                  45
Glu Ile Leu Gln Glu Ala Gly Ser Arg Gly Gly Glu Glu Pro Gly Arg 
     50                  55                  60
Ser Tyr Gly Glu Glu Asp Phe Glu Tyr His Arg Gln Ser Ser His His 
 65                  70                  75                  80
Ile His His Pro Leu Ser Thr His Leu Pro Pro Asp Ala Arg Arg Arg 
                 85                  90                  95
Lys Thr Pro Gln Gly Pro Gly Arg Lys Pro Arg Arg Arg Pro Gly Ala 
             100                105                110
Ser Pro Thr Gly Glu Thr Pro Thr Ile Glu Glu Gly Glu Glu Asp Glu 
         115                120                125
Asp Glu Val Gly Glu Ala Glu Gly Phe Arg Ala Pro Pro Gln Gln Pro 
     130                135                140
Ser Pro Ala Ser Ser Pro Ser Ala Val Gln Phe Phe Leu Gln Glu Asp 
 145                150                155                160
Glu Gly Thr Asp Arg Lys Ala Glu Arg Thr Ser Pro Ser Pro Pro Thr 
                 165                170                175
Gln Thr Pro His Gln Glu Ala Ala Pro Arg Ala Ser Lys Gly Ala Gln 
             180                185                190
Thr Gly Thr Leu Val Glu Glu Met Val Ala Val Ala Ser Gly Thr Ala 
         195                200                205
Gly Gly Asp Asp Gly Gly Ala Ala Gly Arg Pro Leu Thr Lys Ala Gln 
     210                215                220
Pro Gly His Arg Ser Tyr Asn Leu Gln Glu Arg Arg Arg Ile Gly Ser 
 225                230                235                240
Met Thr Gly Val Glu Gln Ala Leu Leu Pro Arg Val Pro Thr Asp Glu 
                 245                250                255
Ser Glu Ala Gln Thr Leu Ala Thr Ala Asp Leu Asp Leu Met Lys Ser 
             260                265                270
His Arg Phe Glu Asp Val Pro Gly Val Arg Arg His Leu Val Arg Lys 
         275                280                285
Asn Ala Lys Gly Ser Thr Gln Ala Ala Arg Glu Gly Arg Glu Pro Gly 
     290                295                300
Pro Thr Pro Arg Ala Arg Pro Arg Ala Pro His Lys Pro His Glu Val 
 305                310                315                320
Phe Val Glu Leu Asn Glu Leu Gln Leu Asp Lys Asn Gln Glu Pro Gln 
                 325                330                335
Trp Arg Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Asp Val Glu Glu 
             340                345                350
Glu Thr Glu Arg Trp Gly Lys Pro His Val Ala Ser Leu Ser Phe Arg 
         355                360                365
Ser Leu Leu Glu Leu Arg Arg Thr Leu Ala His Gly Ala Val Leu Leu 
     370                375                380
Asp Leu Asp Gln Gln Thr Leu Pro Gly Val Ala His Gln Val Val Glu 
 385                390                395                400
Gln Met Val Ile Ser Asp Gln Ile Lys Ala Glu Asp Arg Ala Asn Val 
                 405                410                415
Leu Arg Ala Leu Leu Leu Lys His Ser His Pro Ser Asp Glu Lys Glu 
             420                425                430
Phe Ser Phe Pro Arg Asn Ile Ser Ala Gly Ser Leu Gly Ser Leu Leu 
         435                440                445
Gly His His His Ala Gln Gly Thr Glu Ser Asp Pro His Val Thr Glu 
     450                455                460
Pro Leu Ile Gly Gly Val Pro Glu Thr Arg Leu Glu Val Asp Arg Glu 
 465                470                475                480
Arg Glu Leu Pro Pro Pro Ala Pro Pro Ala Gly Ile Thr Arg Ser Lys 
                 485                490                495
Ser Lys His Glu Leu Lys Leu Leu Glu Lys Ile Pro Glu Asn Ala Glu 
             500                505                510
Ala Thr Val Val Leu Val Gly Cys Val Glu Phe Leu Ser Arg Pro Thr 
         515                520                525
Met Ala Phe Val Arg Leu Arg Glu Ala Val Glu Leu Asp Ala Val Leu 
     530                535                540
Glu Val Pro Val Pro Val Arg Phe Leu Phe Leu Leu Leu Gly Pro Ser 
 545                550                555                560
Ser Ala Asn Met Asp Tyr His Glu Ile Gly Arg Ser Ile Ser Thr Leu 
                 565                570                575
Met Ser Asp Lys Gln Phe His Glu Ala Ala Tyr Leu Ala Asp Glu Arg 
             580                585                590
Asp Asp Leu Leu Thr Ala Ile Asn Ala Phe Leu Asp Cys Ser Val Val 
         595                600                605
Leu Pro Pro Ser Glu Val Gln Gly Glu Glu Leu Leu Arg Ser Val Ala 
     610                615                620
His Phe Gln Arg Gln Met Leu Lys Lys Arg Glu Glu Gln Gly Arg Leu 
 625                630                635                640
Leu Pro Pro Gly Ala Gly Leu Glu Pro Lys Ser Ala Gln Asp Lys Ala 
                 645                650                655
Leu Leu Gln Met Val Glu Val Ala Gly Ala Ala Glu Asp Asp Pro Leu 
             660                665                670
Arg Arg Thr Gly Arg Pro Phe Gly Gly Leu Ile Arg Asp Val Arg Arg 
         675                680                685
Arg Tyr Pro His Tyr Leu Ser Asp Phe Arg Asp Ala Leu Asp Pro Gln 
     690                695                700
Cys Leu Ala Ala Val Ile Phe Ile Tyr Phe Ala Ala Leu Ser Pro Ala 
 705                710                715                720
Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Gln Asp Leu Ile Gly 
                 725                730                735
Val Ser Glu Leu Ile Met Ser Thr Ala Leu Gln Gly Val Ile Phe Cys 
             740                745                750
Leu Leu Gly Ala Gln Pro Leu Leu Val Ile Gly Phe Ser Gly Pro Leu 
         755                760                765
Leu Val Phe Glu Glu Ala Phe Phe Ser Phe Cys Lys Ser Asn Gln Leu 
     770                775                780
Glu Tyr Leu Val Gly Arg Val Trp Ile Gly Phe Trp Leu Val Leu Leu 
 785                790                795                800
Ala Leu Leu Met Val Ala Leu Glu Gly Ser Phe Leu Val Arg Phe Val 
                 805                810                815
Ser Arg Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser Leu Ile Phe 
             820                825                830
Ile Tyr Glu Thr Phe Tyr Lys Leu Ile Lys Ile Phe Gln Glu His Pro 
         835                840                845
Leu His Gly Cys Ser Val Ser Asn Asp Ser Glu Ala Asp Ser Ser Ser 
     850                855                860
Asn Asn Met Thr Trp Ala Ala Thr Thr Leu Ala Pro Asp Asn Ser Ser 
 865                870                875                880
Ala Ser Gly Gln Glu Arg Pro Arg Gly Gln Pro Asn Thr Ala Leu Leu 
                 885                890                895
Ser Leu Val Leu Met Ala Gly Thr Phe Phe Ile Ala Phe Phe Leu Arg 
             900                905                910
Lys Phe Lys Asn Ser Arg Phe Phe Pro Gly Arg Ile Arg Arg Val Ile 
         915                920                925
Gly Asp Phe Gly Val Pro Ile Ala Ile Leu Ile Met Val Leu Val Asp 
     930                935                940
Tyr Ser Ile Glu Asp Thr Tyr Thr Gln Lys Leu Ser Val Pro Ser Gly 
 945                950                955                960
Phe Ser Val Thr Ala Pro Asp Lys Arg Gly Trp Val Ile Asn Pro Leu 
                 965                970                975
Gly Glu Lys Thr Pro Phe Pro Val Trp Met Met Val Ala Ser Leu Leu 
             980                985                990
Pro Ala Val Leu Val Phe Ile Leu Ile Phe Met Glu Thr Gln Ile Thr 
         995                1000                1005
Thr Leu Ile Ile Ser Lys Lys Glu Arg Met Leu Gln Lys Gly Ser Gly 
     1010                1015                1020
Phe His Leu Asp Leu Leu Leu Ile Val Ala Met Gly Gly Ile Cys Ala 
 1025                1030                1035                1040
Leu Phe Gly Leu Pro Trp Leu Ala Ala Ala Thr Val Arg Ser Val Thr 
                 1045                1050                1055
His Ala Asn Ala Leu Thr Val Met Ser Lys Ala Val Ala Pro Gly Asp 
             1060                1065                1070
Lys Pro Lys Ile Gln Glu Val Lys Glu Gln Arg Val Thr Gly Leu Leu 
         1075                1080                1085
Val Ala Leu Leu Val Gly Leu Ser Met Val Ile Gly Asp Leu Leu Arg 
     1090                1095                1100
Gln Ile Pro Leu Ala Val Leu Phe Gly Ile Phe Leu Tyr Met Gly Val 
 1105                1110                1115                1120
Thr Ser Leu Asn Gly Ile Gln Phe Tyr Glu Arg Leu His Leu Leu Leu 
                 1125                1130                1135
Met Pro Pro Lys His His Pro Asp Val Thr Tyr Val Lys Lys Val Arg 
             1140                1145                1150
Thr Met Arg Met His Leu Phe Thr Ala Leu Gln Leu Leu Cys Leu Ala 
         1155                1160                1165
Leu Leu Trp Ala Val Met Ser Thr Ala Ala Ser Leu Ala Phe Pro Phe 
     1170                1175                1180
Ile Leu Ile Leu Thr Val Pro Leu Arg Met Val Val Leu Thr Arg Ile 
 1185                1190                1195                1200
Phe Thr Glu Arg Glu Met Lys Cys Leu Asp Ala Asn Glu Ala Glu Pro 
                 1205                1210                1215
Val Phe Asp Glu Cys Glu Gly Val Asp Glu Tyr Asn Glu Met Pro Met 
             1220                1225                1230
Pro Val 
         1235



<210> 2615
<211> 8277
<212> DNA
<213> Homo sapiens
<308> U76667
<400> 2615

gtaggcgga  aggtggtgg  gggggacgg  cagggccgc  gagggagga  gggaggggg  60
aggagaggg  ggaactcgg  actcgagcg  ggagggagt  gaagtggag  aaagggcgg  120
gactggggc  cggggaacc  cggtcttgg  gagaaggat  gggaggcgg  tggagtgct  180
gtcggaagc  ggcattccg  ggtcccctt  tcagagttc  ctaaagcca  ggtgccgcg  240
cccctgcca  caggagggg  tagtctccc  gaggcgccg  cggccctcc  actccccgg  300
tggctccag  ccacccctc  cctccggcc  ccccgcata  tccttcagt  ccgtccggg  360
cgcccagac  gggggttgc  cggggcccc  atccccaat  tccgggttg  gaggcgaag  420
caggaaagg  gggtggcgg  taaggtcgg  acaaggggt  agacagaag  gggagcagc  480
gggtgggaa  gggaaagat  agcccggag  gttggacct  actcccggg  tcggtttgt  540
caggcgggg  gttctgtgc  gggtgtgag  ggcggcact  cctgaaacc  agggtctac  600
ttatccccc  tcgtttccc  cgccagccc  acatggaag  gctgcggaa  ttacgagtt  660
acttggggg  tggttaatg  ccaagtggg  gtccgaggt  ctaatccct  ggtcaaggg  720
agagatact  atcctctgg  ccggtcggg  ctggtcccg  gaatgtgcc  ctacccgga  780
tatcggcac  gatgctctg  acagaagct  ctttgtgtt  tgggacagc  ggggagggg  840
tgcagagga  tgtggagga  cgcgacgag  gcacagcct  aggtgggag  gggcgcctg  900
aggtgctct  ggcggactc  ccccacacc  ttcccagac  gggtgcact  acgctcacc  960
acaccaccc  ccctggctg  aggcctgct  agggggagg  gaagagcgt  gttagccaa  1020
ttggagtgc  tgccaagaa  gtgttgcca  gctccccat  ctgggtgac  cccccagac  1080
tatattgtt  gacgctaca  tgacttgtc  tactcctaa  tcaggcacc  ccagtcccc  1140
gcaacacac  gggagcatg  gttgctggg  accgtcact  tttgccagt  ttgggtgcc  1200
cctgtgctg  cccgctagg  atgcgcccc  tatttgcag  gattgggct  cctcctgca  1260
ctccttctc  gcccccacc  cacagtgtc  tccccagac  ccctacagt  acagtcagg  1320
gggtggcag  actgccact  agattttcc  ggctccagg  tctagaggg  cgggatcca  1380
actgcccct  agaggcaga  cctcaaggt  gcggtgccc  ccccctccc  gcccatcac  1440
tgcccctcc  ccattataa  gctctgccc  gcccatgcc  accttctgt  ccttcctct  1500
tctcagtga  tgagtggag  tgagctcct  ccctccacc  agccagcct  cttccctcc  1560
gccggtccc  aaggacctg  gggagggaa  cctcctgcc  gcctgtact  gggaggggg  1620
accccctcc  tgcaggggc  tcttgggct  tctccagag  tcttccatt  gtctgcttc  1680
tgtctcggc  gcccggccc  ggctccacg  ggtgtctca  cctccccac  acaccctct  1740
tggtctcag  cacctctgg  gggtgccct  accctgcga  gctccgttg  ctgcctggg  1800
cttcactcc  ctctttccc  agctcatta  cactccctc  ctcatcttt  ttgctttct  1860
tccgggcct  ggccttgac  cctttctcc  tcatttttc  tgcggcctt  cccacctcc  1920
ctctcctcc  ccctctact  agcctctcg  cccttttcg  cccccctcg  ctcagtcct  1980
tcctgtctc  ttgttcttc  cttttcttc  tataaataa  tctcctctg  gctgtggct  2040
ccgctaagg  ccactctga  gcccttcat  ctccaggag  atccccagc  gcgcagcct  2100
cgcgtggtg  ctcctgccc  cccagggct  tcgatggtg  tcaggcctc  cccccatcc  2160
ggttatgcc  ccgcctcgt  gccctgaaa  ccgcagcga  agcgaaaag  gctaagatt  2220
ggccatgag  agcgcccct  ggcgccccg  caagggcgc  gattctttc  gtacggtga  2280
tgtggcccc  aggtcgcca  cccaacctt  cctccctgg  cagccttgg  tgctccggc  2340
aagggtcct  gccaaccag  ggtgtgagc  tggagactg  gaggatgct  ccatcccta  2400
cctgacttt  catgatggt  gtagggggg  atgggtagt  ggggtatca  acgtcttcc  2460
gtcctgggg  gggagttga  gctgttacc  gaagaccta  gtagcttag  ctcagcggt  2520
gaggaactt  gagaaccct  ggtctctca  ccagcaacc  gtctcagac  cggctggcc  2580
tagaggcgc  ggtcaagtc  gcacgcggg  cagggttct  ggcggagct  gcctgccac  2640
actggccac  ccccctgcc  acgtgccac  caggcccgc  cctccctgc  cccacgtgg  2700
caccgctcc  catggcccc  tttggattt  cctaaggag  cttaatgat  aaccccgtg  2760
cacaatcag  tccgctatt  gtcacactg  cccagaggg  cacgtgact  ggaaggggc  2820
caggctggt  ccctccccc  ccttctcag  ttcacccct  ccggccatg  acttcctcc  2880
gcggcctca  gtgcgaggg  tctgcgacc  tctctcccc  tggcggcaa  ctccctgcg  2940
ctctccccg  cccctcgtc  cacggggct  cttctggtg  gagtggggc  gggcgctta  3000
gggagccag  agatggaca  gagccttcc  cacagaggg  agaagccag  cccctggcc  3060
gctcacctt  tcttatccg  tgttctgcc  gtcccagct  ctccagtcc  cacctcgcc  3120
ctaagaccc  cccttcacc  cagccctcc  cgcgctctt  cttgttctg  ctgctggca  3180
cgctatgga  ggggctgca  acccccgcc  ttggagatc  cgatgccct  caggtccag  3240
agctcttga  caaatattt  gcggcgcct  gagctgaga  cgtgggtgg  tggggggct  3300
gaccaaggc  gcctggcca  gcggctgcc  cttagctgg  ctgagctct  acaagcgcc  3360
cattccctg  cggctgtgc  ggccggccg  tgctccgcg  ccgcaggat  actcaggtg  3420
gggctgtgg  ggtggggtg  ggggtgggg  tagggacct  gcccagggc  cgggccggg  3480
gcctggggg  tgggggagc  ctcctgggg  ctgaagggc  tccattccg  tccctgcgg  3540
gctgggttt  tttgactcg  acaggctct  ggtcggtta  cttggcgcc  ccagaagtt  3600
ctttttggg  tcagcagtt  tcctcaggc  aactggagt  tcttcacta  ctgtcatgt  3660
aacttcccg  ttcacacgc  ctccctcca  gctgcagat  ggctggaca  acgggattt  3720
ttccacctg  cctgaactg  ctacacagc  aagggggct  ggctgggat  agggtagct  3780
agaacccag  ggacagctg  tggggggac  gggtctctg  atctgaggg  gcagactgc  3840
ggggggaca  tgggtcact  tgtttgaag  gatgtctac  ggtagggtg  ctggcttcc  3900
gcatttgag  gggcagact  cttgggagg  ctgggtccc  atatttgtt  ccttttttt  3960
tgtttttgt  ttgagacgg  gtctcactc  gtcacccag  ctggagtgc  gtggcacga  4020
cttggctca  tgcaacctc  gcctcccag  ttcaagtaa  tctcctgcc  cagcctcct  4080
agtagctgg  attactggt  tccgccacc  cgcctggct  atttttgtg  ttttagtag  4140
gatggggtt  caccatgtt  gtcaggctg  tcttgaact  ctgacctcc  gcaatccac  4200
cacctcagc  tcccaaagt  ctgggatta  aggtgtgag  cactgtgcc  ggcctgggt  4260
cctatattt  agggacagc  gctgggggg  tatagagcc  ccagcatta  aggagatag  4320
tgctggcgg  ggagggttc  tgggtctct  gcactggga  gggtgaggt  tcggggtac  4380
attcccagt  agccctgtg  gttttctct  tgccttctt  ctcacagcc  gagccagag  4440
gcttgggcc  tgggacgcc  gggttcccc  agcaggagg  agacgaact  caccgcacc  4500
tgggcgtgg  gcggtttga  gagatccta  aggaggccg  gtctcgtgg  ggggaggag  4560
caggccgca  ctatgggga  gaagacttt  agtgtgagg  ggcaggcag  ggaggggga  4620
gtgggggga  caggtttga  tgtccagca  agaagggac  ggggtccta  tgggaggag  4680
ggggctagg  ggcaggatg  caggggagg  acactgtgc  tgccacagc  aagtccccc  4740
cctccctgc  gaccaccgc  agtcctccc  ccacatcca  cacccactg  ccacccacc  4800
gcctccgga  gcacgccgc  gcaagacac  ccagggccc  ggacggaag  ctcgaaggc  4860
cccgggagc  tccccgact  gagaaaccc  gaccattga  gagggggag  aagatgagg  4920
tgaggccag  gaggctgag  gggcccggg  tctcactca  ccgtcccct  tctccacac  4980
ctcctcggt  caggtgcgc  gggtgcggg  tcctaggga  tgtcggcag  gccctggcc  5040
ggtcactcc  gcccatgtg  gtccctgtt  cagttcttt  tccaagagg  tgacagtgc  5100
gaccggaag  cagagagga  cagtccatc  tcccctgca  cactgcccc  ccaggaggc  5160
actcctcgg  cctccaaag  ggcccaggc  gggtaagta  accccaatc  acagtgtcc  5220
caacagaca  ttcccctgc  aggatagtg  ggtgatgct  gaacaaagc  tgagccttg  5280
aatcaccag  ccagggttc  aatcccagg  ccgcactca  tggctgggc  agtaactta  5340
ttaagctct  caagcccca  gttcctcat  agaaaccaa  cataacaga  cgtttctca  5400
tgggcggct  tagggatta  gggtggtgt  aattaaagt  ctaagtatg  tttagcctg  5460
cagagaaca  gcgctgcct  agctgcctc  cacccctga  ccgtctccc  cccctgcct  5520
tggtgtagt  ggagcaata  ccagcactg  ctcaggtac  ggactggtg  cctcccagc  5580
cttgctgga  gccccaggg  tcaagaggc  aaggagacc  cctctcctt  gggcactgc  5640
aacacacgc  ggttggaaa  cagatgtta  catgtgaga  ggcatcagc  tgttgtcac  5700
gcacccagt  gctggttca  gcaaagtgt  agtaccagt  gatgattgg  atttggggg  5760
aggcttcct  gagaaaatg  ctttgaact  ggtctcaag  tcactacta  cacggacct  5820
ttgttttct  ggtgccagg  agcgtgaag  gctgcggga  gtgaagggc  tgttgtccc  5880
tctgggagc  cataacctg  tgggaccgt  gcacagatg  gggcggcgg  ttacagcgg  5940
cttaggggc  ccaggatgg  agggaggag  ctggggctt  cgagaaagc  tggcatcag  6000
aaagggtcg  atttgtggg  cagggcacg  gggggctag  agagcctgg  catgggagg  6060
gactctgat  ttgagtcag  gcttggagc  ctgggggcc  ttgatgttg  gagagaggg  6120
taggaccac  tggcagggc  ctggccacc  agtgtggca  agagaaggg  gagagcaga  6180
gctggcgtc  gtgaagcct  aggcttacc  ctcctccca  ggcaggaag  tgtctgcca  6240
ctccaaggc  cggtgccac  gactttatt  ctcttgatt  aacataggc  cctgtgaac  6300
tctgagtcc  atgtctagg  atgtgccag  gggtgaggg  gcaggggga  gaatgctga  6360
tgtcaggaa  cagcgtcct  agctccttt  ctgcaccag  acctgcact  ggacttttc  6420
aaaatctca  ccctcatgg  accgcaaag  ctggtctca  ccctggctg  tgaggagca  6480
ttgacgttc  cagtggccg  tcagagggg  ctcggggtg  ccgtttggg  ctgcacagc  6540
agaaaaggg  ggagcttgg  gttcggatg  tggcagtct  catccagaa  cctccccgt  6600
cccgtgccc  cacctcccg  gagtgggag  taggagggc  tggagtccg  tgtgggtcc  6660
ctccccacc  cctgcgtgg  tgctgggcg  cggggagga  gccaggttt  tcgggctca  6720
ggccattct  tctgcctag  acccaggtg  aggaggcgg  ggcggaggc  gtggcggtg  6780
ccagtggca  agcaggggg  gacgacggg  gtgcctcgg  gcgccccct  cccaaagcc  6840
agcctgggc  ccgcagcta  aaccttcag  agaggaggc  catcgggag  atgactggg  6900
ctgagcagg  actgctgcc  cgggtcccc  cggatgaga  tgaggccca  acgctggcc  6960
cggccgacc  agacctcat  aagagtaag  gctgggcct  ggccaagcc  ggcactggt  7020
ggcaaagga  tgagagaaa  ggggagccc  accttggtc  tctgccccc  caggtcacc  7080
gtttgagga  gttcctggg  tgcggcggc  cttggtgcg  aagaatgcc  aaggttcca  7140
acagagtgg  cgagaaggg  gggagcctg  ccccacacc  cgggcccga  cccgggccc  7200
ccacaagcc  catgaggta  catgctctg  ttcatgctc  tccatcaac  tcccacacg  7260
ccctgcccc  acctctcag  ccagctgta  tctcaagcc  cagggttgc  actgttgtt  7320
tgttgttgt  tgagacagt  tcgctctgt  gcccaggat  gagtgcagt  gtgtgatct  7380
agctcactg  aacctctgc  tcctgggtt  aagcgattc  cctgcctca  cctcctgag  7440
agctgggat  acaggcacc  gctacgccc  gctaatttt  gtattttta  tagagatgc  7500
gttttacca  gttggccag  ctgttctcc  actcctagc  tctaggaat  cgcccgcct  7560
ggcctccca  agtgctggg  ttacaggca  gagctgccg  gccgggccc  gggatgcca  7620
ctttggttg  gaaggttgt  cactgcaca  gagtgcagt  tacacatct  agagcttat  7680
gacttgggc  ctgtgatta  cctccccat  gtggatgtc  ttgatttga  tattgtggt  7740
ataattcac  tctgttaaa  ggcctgcaa  acgccattg  tttcatata  agtggccat  7800
tctcaagtg  tcactctga  gcacgtagc  tgccatgtg  ttttccttt  catccttct  7860
acagttctt  gaggtgggt  ttattccca  ttgacagat  agggaaact  cgtctcatt  7920
gttagtcag  tgtccaggg  cccagctgg  tgtgggact  gtgcgcctg  gcaccaccc  7980
ctgtgctcg  gctctccag  gtcacttgg  tccctctga  accactcac  tgtgacacc  8040
accccaggg  tcgctccgg  tctgtaccc  gaaatgcct  ctcttctct  cccaaggtg  8100
ttgtggagc  gaatgagtt  ctcctggac  aaaaccagg  gccccagtg  cgggagaca  8160
ctcgctgga  caaatttga  gaggacgtg  aggaggaga  cgagcgctg  gggaagccc  8220
acgtggcct  cctctcctt  cgcagtctc  tggagctcc  caggaccct  gcccatg  8277



<210> 2616
<211> 1241
<212> PRT
<213> Homo sapiens
<308> AAF19583
<400> 2616

Met Ser Ser Ala Pro Arg Arg Pro Ala Lys Gly Ala Asp Ser Phe Cys 
  1               5                  10                  15
Thr Pro Glu Pro Glu Ser Leu Gly Pro Gly Thr Pro Gly Phe Pro Glu 
             20                  25                  30
Gln Glu Glu Asp Glu Leu His Arg Thr Leu Gly Val Glu Arg Phe Glu 
         35                  40                  45
Glu Ile Leu Gln Glu Ala Gly Ser Arg Gly Gly Glu Glu Pro Gly Arg 
     50                  55                  60
Ser Tyr Gly Glu Glu Asp Phe Glu Tyr His Arg Gln Ser Ser His His 
 65                  70                  75                  80
Ile His His Pro Leu Ser Thr His Leu Pro Pro Asp Ala Arg Arg Arg 
                 85                  90                  95
Lys Thr Pro Gln Gly Pro Gly Arg Lys Pro Arg Arg Arg Pro Gly Ala 
             100                105                110
Ser Pro Thr Gly Glu Thr Pro Thr Ile Glu Glu Gly Glu Glu Asp Glu 
         115                120                125
Asp Glu Ala Ser Glu Ala Glu Gly Ala Arg Ala Leu Thr Gln Pro Ser 
     130                135                140
Pro Val Ser Thr Pro Ser Ser Val Gln Phe Phe Leu Gln Glu Asp Asp 
 145                150                155                160
Ser Ala Asp Arg Lys Ala Glu Arg Thr Ser Pro Ser Ser Pro Ala Pro 
                 165                170                175
Leu Pro His Gln Glu Ala Thr Pro Arg Ala Ser Lys Gly Ala Gln Ala 
             180                185                190
Gly Thr Gln Val Glu Glu Ala Glu Ala Glu Ala Val Ala Val Ala Ser 
         195                200                205
Gly Thr Ala Gly Gly Asp Asp Gly Gly Ala Ser Gly Arg Pro Leu Pro 
     210                215                220
Lys Ala Gln Pro Gly His Arg Ser Tyr Asn Leu Gln Glu Arg Arg Arg 
 225                230                235                240
Ile Gly Ser Met Thr Gly Ala Glu Gln Ala Leu Leu Pro Arg Val Pro 
                 245                250                255
Thr Asp Glu Ile Glu Ala Gln Thr Leu Ala Thr Ala Asp Leu Asp Leu 
             260                265                270
Met Lys Ser His Arg Phe Glu Asp Val Pro Gly Val Arg Arg His Leu 
         275                280                285
Val Arg Lys Asn Ala Lys Gly Ser Thr Gln Ser Gly Arg Glu Gly Arg 
     290                295                300
Glu Pro Gly Pro Thr Pro Arg Ala Arg Pro Arg Ala Pro His Lys Pro 
 305                310                315                320
His Glu Val Phe Val Glu Leu Asn Glu Leu Leu Leu Asp Lys Asn Gln 
                 325                330                335
Glu Pro Gln Trp Arg Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Asp 
             340                345                350
Val Glu Glu Glu Thr Glu Arg Trp Gly Lys Pro His Val Ala Ser Leu 
         355                360                365
Ser Phe Arg Ser Leu Leu Glu Leu Arg Arg Thr Leu Ala His Gly Ala 
     370                375                380
Val Leu Leu Asp Leu Asp Gln Gln Thr Leu Pro Gly Val Ala His Gln 
 385                390                395                400
Val Val Glu Gln Met Val Ile Ser Asp Gln Ile Lys Ala Glu Asp Arg 
                 405                410                415
Ala Asn Val Leu Arg Ala Leu Leu Leu Lys His Ser His Pro Ser Asp 
             420                425                430
Glu Lys Asp Phe Ser Phe Pro Arg Asn Ile Ser Ala Gly Ser Leu Gly 
         435                440                445
Ser Leu Leu Gly His His His Gly Gln Gly Ala Glu Ser Asp Pro His 
     450                455                460
Val Thr Glu Pro Leu Met Gly Gly Val Pro Glu Thr Arg Leu Glu Val 
 465                470                475                480
Glu Arg Glu Arg Asp Val Pro Pro Pro Ala Pro Pro Ala Gly Ile Thr 
                 485                490                495
Arg Ser Lys Ser Lys His Glu Leu Lys Leu Leu Glu Lys Ile Pro Glu 
             500                505                510
Asn Ala Glu Ala Thr Val Val Leu Val Gly Cys Val Glu Phe Leu Ser 
         515                520                525
Arg Pro Thr Met Ala Phe Val Arg Leu Arg Glu Ala Val Glu Leu Asp 
     530                535                540
Ala Val Leu Glu Val Pro Val Pro Val Arg Phe Leu Phe Leu Leu Leu 
 545                550                555                560
Gly Pro Ser Ser Ala Asn Met Asp Tyr His Glu Ile Gly Arg Ser Ile 
                 565                570                575
Ser Thr Leu Met Ser Asp Lys Gln Phe His Glu Ala Ala Tyr Leu Ala 
             580                585                590
Asp Glu Arg Glu Asp Leu Leu Thr Ala Ile Asn Ala Phe Leu Asp Cys 
         595                600                605
Ser Val Val Leu Pro Pro Ser Glu Val Gln Gly Glu Glu Leu Leu Arg 
     610                615                620
Ser Val Ala His Phe Gln Arg Gln Met Leu Lys Lys Arg Glu Glu Gln 
 625                630                635                640
Gly Arg Leu Leu Pro Thr Gly Ala Gly Leu Glu Pro Lys Ser Ala Gln 
                 645                650                655
Asp Lys Ala Leu Leu Gln Met Val Glu Ala Ala Gly Ala Ala Glu Asp 
             660                665                670
Asp Pro Leu Arg Arg Thr Gly Arg Pro Phe Gly Gly Leu Ile Arg Asp 
         675                680                685
Val Arg Arg Arg Tyr Pro His Tyr Leu Ser Asp Phe Arg Asp Ala Leu 
     690                695                700
Asp Pro Gln Cys Leu Ala Ala Val Ile Phe Ile Tyr Phe Ala Ala Leu 
 705                710                715                720
Ser Pro Ala Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Gln Asp 
                 725                730                735
Leu Ile Gly Val Ser Glu Leu Ile Met Ser Thr Ala Leu Gln Gly Val 
             740                745                750
Val Phe Cys Leu Leu Gly Ala Gln Pro Leu Leu Val Ile Gly Phe Ser 
         755                760                765
Gly Pro Leu Leu Val Phe Glu Glu Ala Phe Phe Ser Phe Cys Ser Ser 
     770                775                780
Asn His Leu Glu Tyr Leu Val Gly Arg Val Trp Ile Gly Phe Trp Leu 
 785                790                795                800
Val Phe Leu Ala Leu Leu Met Val Ala Leu Glu Gly Ser Phe Leu Val 
                 805                810                815
Arg Phe Val Ser Arg Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser 
             820                825                830
Leu Ile Phe Ile Tyr Glu Thr Phe Tyr Lys Leu Val Lys Ile Phe Gln 
         835                840                845
Glu His Pro Leu His Gly Cys Ser Ala Ser Asn Ser Ser Glu Val Asp 
     850                855                860
Gly Gly Glu Asn Met Thr Trp Ala Gly Ala Arg Pro Thr Leu Gly Pro 
 865                870                875                880
Gly Asn Arg Ser Leu Ala Gly Gln Ser Gly Gln Gly Lys Pro Arg Gly 
                 885                890                895
Gln Pro Asn Thr Ala Leu Leu Ser Leu Val Leu Met Ala Gly Thr Phe 
             900                905                910
Phe Ile Ala Phe Phe Leu Arg Lys Phe Lys Asn Ser Arg Phe Phe Pro 
         915                920                925
Gly Arg Ile Arg Arg Val Ile Gly Asp Phe Gly Val Pro Ile Ala Ile 
     930                935                940
Leu Ile Met Val Leu Val Asp Tyr Ser Ile Glu Asp Thr Tyr Thr Gln 
 945                950                955                960
Lys Leu Ser Val Pro Ser Gly Phe Ser Val Thr Ala Pro Glu Lys Arg 
                 965                970                975
Gly Trp Val Ile Asn Pro Leu Gly Glu Lys Ser Pro Phe Pro Val Trp 
             980                985                990
Met Met Val Ala Ser Leu Leu Pro Ala Ile Leu Val Phe Ile Leu Ile 
         995                1000                1005
Phe Met Glu Thr Gln Ile Thr Thr Leu Ile Ile Ser Lys Lys Glu Arg 
     1010                1015                1020
Met Leu Gln Lys Gly Ser Gly Phe His Leu Asp Leu Leu Leu Ile Val 
 1025                1030                1035                1040
Ala Met Gly Gly Ile Cys Ala Leu Phe Gly Leu Pro Trp Leu Ala Ala 
                 1045                1050                1055
Ala Thr Val Arg Ser Val Thr His Ala Asn Ala Leu Thr Val Met Ser 
             1060                1065                1070
Lys Ala Val Ala Pro Gly Asp Lys Pro Lys Ile Gln Glu Val Lys Glu 
         1075                1080                1085
Gln Arg Val Thr Gly Leu Leu Val Ala Leu Leu Val Gly Leu Ser Ile 
     1090                1095                1100
Val Ile Gly Asp Leu Leu Arg Gln Ile Pro Leu Ala Val Leu Phe Gly 
 1105                1110                1115                1120
Ile Phe Leu Tyr Met Gly Val Thr Ser Leu Asn Gly Ile Gln Phe Tyr 
                 1125                1130                1135
Glu Arg Leu His Leu Leu Leu Met Pro Pro Lys His His Pro Asp Val 
             1140                1145                1150
Thr Tyr Val Lys Lys Val Arg Thr Leu Arg Met His Leu Phe Thr Ala 
         1155                1160                1165
Leu Gln Leu Leu Cys Leu Ala Leu Leu Trp Ala Val Met Ser Thr Ala 
     1170                1175                1180
Ala Ser Leu Ala Phe Pro Phe Ile Leu Ile Leu Thr Val Pro Leu Arg 
 1185                1190                1195                1200
Met Val Val Leu Thr Arg Ile Phe Thr Asp Arg Glu Met Lys Cys Leu 
                 1205                1210                1215
Asp Ala Asn Glu Ala Glu Pro Val Phe Asp Glu Arg Glu Gly Val Asp 
             1220                1225                1230
Glu Tyr Asn Glu Met Pro Met Pro Val 
         1235                1240



<210> 2617
<211> 4057
<212> DNA
<213> Rattus norvegicus
<308> J05166
<400> 2617

aaaagagtt  ggagaagtt  ggagcggcg  gggcgcgcc  cggggtggg  accgggaaa  60
cgtcgggag  gcgcgaggg  tccggagga  caggggaga  ccggagacc  ccgggacac  120
aaatctaga  ctagcgggt  atgcctcca  cttgttgcc  tgaaagccg  agcgacagt  180
agaagggct  agatttggc  atgagcagc  cccccaggc  ccccgcctc  ggcgcagat  240
ctttgcaca  gccagagcc  gagagcctg  gccccggaa  acctgggtt  cctgagcaa  300
aggaggaag  tgaacttcg  accttaggt  tggagcggt  cgaggagat  ctccaggaa  360
ctggatcca  aggaggaga  gagccaggc  gcagctatg  ggaggaaga  tttgaatac  420
accgccagt  ctcccacca  atccatcat  cactctcca  ccacctgcc  cctgacgcc  480
gccgtcgca  gactcccca  ggcccagga  ggaaacctc  gaggcgccc  ggagcctct  540
ccactggag  gacccccac  attgaggaa  gggaggaag  tgaggatga  gtcggtgaa  600
ctgaagggt  cagagctcc  ccgcaacaa  catctcctg  ctcttcacc  tctgcagtt  660
agttttttc  ccaagagga  gaaggtaca  ataggaagg  agagagaac  agcccatct  720
cccctacac  gacgcccca  caggaagca  ctccccggg  cagcaaagg  gcacagaca  780
gaactctgg  ggaggagat  gtggccgtg  ccagcggca  ggctggagg  gacgacgga  840
gtgctgcag  gcgccccct  accaaagcc  agcctggac  tcgaagtta  aaccttcag  900
agagaaggc  aattggcag  atgacaggg  tggagcagg  cctgctgcc  agggtccct  960
ctgatgaga  tgaggctca  acgctggcc  cagctgacc  cgacctcat  aaaagtcac  1020
ggtttgagg  cgttccggg  gtacggcga  atttggtga  gaagaatgc  aaagggtct  1080
cacaggctg  ccgggaagg  cgagagcct  gccccacac  tcgggcacg  ccacgggcc  1140
cccataagc  tcatgaggt  ttcgtagag  tgaatgaat  gcagttgga  aaaaaccag  1200
agcctcagt  gcgggagac  gcccggtgg  taaaatttg  ggaggacgt  gaagaggag  1260
ctgagcgct  gggcaagcc  cacgtggca  cactgtcct  ccgcagcct  ctggagctc  1320
gcaggacac  ggcccatgg  gctgtgctc  tggacctcg  tcagcagac  ctgcctggg  1380
tggcccatc  ggtggtcga  cagatggtt  tctctgacc  gatcaaagc  gaggacaga  1440
ccaatgtgc  acgagccct  ctgctgaaa  acagccacc  aagtgatga  aaagaattc  1500
ccttccccc  gaacatctc  gcgggctct  tgggctctc  cctggggca  caccacgcc  1560
aggggactg  gagtgatcc  cacgtcact  agcctctca  cggtggtgt  cctgagacc  1620
ggctggagg  ggatagaga  cgtgagctg  cgcccccag  cccacctgc  ggtattacc  1680
gctccaagt  caagcatga  ctgaagctg  tggagaaga  ccctgagaa  gcagaggcc  1740
cagtggtcc  cgtgggctg  gtggagttc  tctcccgcc  caccatggc  tttgtgcgc  1800
tgcgggagg  tgtggaact  gatgcagta  tggaggtgc  tgtgcctgt  cgcttcctc  1860
tcctgctgc  ggggcccag  agcgccaac  tggactacc  tgagattgg  cgatccatc  1920
ccaccctca  gtctgacaa  caattccac  aggcagcct  cctggcaga  gaacgggat  1980
acttgctga  tgctatcaa  gccttcctg  actgcagtg  tgtgctacc  ccttctgaa  2040
tgcagggcg  ggagctgct  cgttctgtt  cccatttcc  gcgccagat  ctaaagaag  2100
gagaggagc  gggccgcct  ctgccccct  gtgctgggc  agagcccaa  tctgcccaa  2160
ataaggcac  cctgcagat  gtagaggtg  caggtgcag  tgaagatga  ccccttcgg  2220
ggacaggcc  gccctttgg  gggctgatc  gtgacgtgc  gcggcgcta  ccgcactac  2280
tgagtgact  ccgagatgc  ctagacccc  agtgcctgg  tgctgtcat  ttcatctac  2340
ttgccgccc  gtcgcctgc  atcactttt  gggggctac  gggggagaa  acacaggac  2400
tgataggag  gtcagagct  atcatgtcc  cagcgctcc  gggagtgat  ttctgcctg  2460
tgggcgccc  gccactgct  gtgatcggc  tctcggggc  tctgctggt  ttcgaggag  2520
ccttcttct  gttctgcaa  agcaaccag  tggagtact  ggtgggccg  gtttggatt  2580
gcttctggc  ggtgctcct  gccctgctc  tggtggctc  ggaggggag  ttcctggtc  2640
gctttgtct  ccgattcac  caggagatc  ttgccttcc  catatcact  atcttcatc  2700
atgagacct  ctataagct  atcaagatc  ttcaggagc  ccccctcca  ggctgctca  2760
tctccaacg  ctcagaggc  gacagcagc  gtaacaata  gacttgggc  gcaaccaca  2820
tggcaccag  caacagcag  gcgtctggg  aggagaggc  ccggggcca  cctaacact  2880
ccttgctat  actggtgct  atggccggc  ctttcttca  cgccttctt  ctgcgcaaa  2940
tcaagaaca  ccggttctt  cctggccgg  tccggcggg  aattgggga  tttggggtg  3000
ccatcgcga  cctcatcat  gtgcttgtg  attacagta  tgaggatac  tacacccag  3060
agctaagtg  gcccagtgg  ttctcagtg  cagccccag  caagcgggg  tgggtcatc  3120
acccccttg  agagaagac  cctttccct  tgtggatga  ggtggccag  ctgttgcct  3180
ccgttctgg  gttcatcct  atcttcatg  agacacaga  caccacgtt  atcatctcc  3240
agaaagagc  gatgcttca  aagggctct  gcttccacc  tgatctgtt  ctcattgta  3300
ccatgggtg  catctgtgc  ctctttggc  tgccttggt  ggctgctgc  actgtccgc  3360
ctgtcactc  tgccaatgc  ctcactgtc  tgagcaagg  tgtggcacc  ggtgacaaa  3420
ccaagattc  ggaagtcaa  gagcagcgg  tgaccgggc  gctggtggc  ctgcttgtg  3480
gactctcca  ggtcattgg  gacctactg  ggcagatcc  cctggctgt  ctctttggc  3540
ttttcttat  catgggagt  acttccctt  atgggatcc  attctacga  cggttgcac  3600
tgctactca  gccgcccaa  caccaccca  atgttacct  tgtcaagaa  gttcggacc  3660
tgcggatgc  cctgttcac  gccttgcag  tgctctgtc  ggccctgct  tgggcggtc  3720
tgtccacag  tgcttccct  gccttcccc  tcatcctca  cctcacagt  cctttgcgc  3780
tggtggtac  tacccggat  ttcactgag  gagaaatga  atgtctgga  gctaatgag  3840
cagagccag  gtttgatga  tgtgaaggt  tggacgagt  caacgagat  cccatgcct  3900
tgtagctgc  gtccagagg  atagcagag  gactaaggg  caggggctg  ggggctggg  3960
agctggggc  cccctcctc  tgtccctcc  catttttat  taagtgaat  atttaaagc  4020
cccttgtcc  caccctgca  taaagtgct  caacccc  4057



<210> 2618
<211> 1234
<212> PRT
<213> Rattus norvegicus
<308> P23347
<400> 2618

Met Ser Ser Ala Pro Arg Arg Pro Ala Ser Gly Ala Asp Ser Leu His 
  1               5                  10                  15
Thr Pro Glu Pro Glu Ser Leu Ser Pro Gly Thr Pro Gly Phe Pro Glu 
             20                  25                  30
Gln Glu Glu Glu Asp Glu Leu Arg Thr Leu Gly Val Glu Arg Phe Glu 
         35                  40                  45
Glu Ile Leu Gln Glu Ala Gly Ser Arg Gly Gly Glu Glu Pro Gly Arg 
     50                  55                  60
Ser Tyr Gly Glu Glu Asp Phe Glu Tyr His Arg Gln Ser Ser His His 
 65                  70                  75                  80
Ile His His Pro Leu Ser Thr His Leu Pro Pro Asp Ala Arg Arg Arg 
                 85                  90                  95
Lys Thr Pro Gln Gly Pro Gly Arg Lys Pro Arg Arg Arg Pro Gly Ala 
             100                105                110
Ser Pro Thr Gly Glu Thr Pro Thr Ile Glu Glu Gly Glu Glu Asp Glu 
         115                120                125
Asp Glu Val Gly Glu Ala Glu Gly Phe Arg Ala Pro Pro Gln Gln Pro 
     130                135                140
Ser Pro Ala Ser Ser Pro Ser Ala Val Gln Phe Phe Leu Gln Glu Asp 
 145                150                155                160
Glu Gly Thr Asp Arg Lys Ala Glu Arg Thr Ser Pro Ser Pro Pro Thr 
                 165                170                175
Gln Thr Pro His Gln Glu Ala Ala Pro Arg Ala Ser Lys Gly Ala Gln 
             180                185                190
Thr Gly Thr Leu Val Glu Glu Met Val Ala Val Ala Ser Gly Thr Ala 
         195                200                205
Gly Gly Asp Asp Gly Gly Ala Ala Gly Arg Pro Leu Thr Lys Ala Gln 
     210                215                220
Pro Gly His Arg Ser Tyr Asn Leu Gln Glu Arg Arg Arg Ile Gly Ser 
 225                230                235                240
Met Thr Gly Val Glu Gln Ala Leu Leu Pro Arg Val Pro Thr Asp Glu 
                 245                250                255
Ser Glu Ala Gln Thr Leu Ala Thr Ala Asp Leu Asp Leu Met Lys Ser 
             260                265                270
His Arg Phe Glu Asp Val Pro Gly Val Arg Arg His Leu Val Arg Lys 
         275                280                285
Asn Ala Lys Gly Ser Thr Gln Ala Ala Arg Glu Gly Arg Glu Pro Gly 
     290                295                300
Pro Thr Pro Arg Ala Arg Pro Arg Ala Pro His Lys Pro His Glu Val 
 305                310                315                320
Phe Val Glu Leu Asn Glu Leu Gln Leu Asp Lys Asn Gln Glu Pro Gln 
                 325                330                335
Trp Arg Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Asp Val Glu Glu 
             340                345                350
Glu Thr Glu Arg Trp Gly Lys Pro His Val Ala Ser Leu Ser Phe Arg 
         355                360                365
Ser Leu Leu Glu Leu Arg Arg Thr Leu Ala His Gly Ala Val Leu Leu 
     370                375                380
Asp Leu Asp Gln Gln Thr Leu Pro Gly Val Ala His Gln Val Val Glu 
 385                390                395                400
Gln Met Val Ile Ser Asp Gln Ile Lys Ala Glu Asp Arg Ala Asn Val 
                 405                410                415
Leu Arg Ala Leu Leu Leu Lys His Ser His Pro Ser Asp Glu Lys Glu 
             420                425                430
Phe Ser Phe Pro Arg Asn Ile Ser Ala Gly Ser Leu Gly Ser Leu Leu 
         435                440                445
Gly His His His Ala Gln Gly Thr Glu Ser Asp Pro His Val Thr Glu 
     450                455                460
Pro Leu Ile Gly Gly Val Pro Glu Thr Arg Leu Glu Val Asp Arg Glu 
 465                470                475                480
Arg Glu Leu Pro Pro Pro Ala Pro Pro Ala Gly Ile Thr Arg Ser Lys 
                 485                490                495
Ser Lys His Glu Leu Lys Leu Leu Glu Lys Ile Pro Glu Asn Ala Glu 
             500                505                510
Ala Thr Val Val Leu Val Gly Cys Val Glu Phe Leu Ser Arg Pro Thr 
         515                520                525
Met Ala Phe Val Arg Leu Arg Glu Ala Val Glu Leu Asp Ala Val Leu 
     530                535                540
Glu Val Pro Val Pro Val Arg Phe Leu Phe Leu Leu Leu Gly Pro Ser 
 545                550                555                560
Ser Ala Asn Met Asp Tyr His Glu Ile Gly Arg Ser Ile Ser Thr Leu 
                 565                570                575
Met Ser Asp Lys Gln Phe His Glu Ala Ala Tyr Leu Ala Asp Glu Arg 
             580                585                590
Asp Asp Leu Leu Thr Ala Ile Asn Ala Phe Leu Asp Cys Ser Val Val 
         595                600                605
Leu Pro Pro Ser Glu Val Gln Gly Glu Glu Leu Leu Arg Ser Val Ala 
     610                615                620
His Phe Gln Arg Gln Met Leu Lys Lys Arg Glu Glu Gln Gly Arg Leu 
 625                630                635                640
Leu Pro Pro Gly Ala Gly Leu Glu Pro Lys Ser Ala Gln Asp Lys Ala 
                 645                650                655
Leu Leu Gln Met Val Glu Val Ala Gly Ala Ala Glu Asp Asp Pro Leu 
             660                665                670
Arg Arg Thr Gly Arg Pro Phe Gly Gly Leu Ile Arg Asp Val Arg Arg 
         675                680                685
Arg Tyr Pro His Tyr Leu Ser Asp Phe Arg Asp Ala Leu Asp Pro Gln 
     690                695                700
Cys Leu Ala Ala Val Ile Phe Ile Tyr Phe Ala Ala Leu Ser Pro Ala 
 705                710                715                720
Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Gln Asp Leu Ile Gly 
                 725                730                735
Val Ser Glu Leu Ile Met Ser Thr Ala Leu Gln Gly Val Ile Phe Cys 
             740                745                750
Leu Leu Gly Ala Gln Pro Leu Leu Val Ile Gly Phe Ser Gly Pro Leu 
         755                760                765
Leu Val Phe Glu Glu Ala Phe Phe Ser Phe Cys Lys Ser Asn Gln Leu 
     770                775                780
Glu Tyr Leu Val Gly Arg Val Trp Ile Gly Phe Trp Leu Val Leu Leu 
 785                790                795                800
Ala Leu Leu Met Val Ala Leu Glu Gly Ser Phe Leu Val Arg Phe Val 
                 805                810                815
Ser Arg Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser Leu Ile Phe 
             820                825                830
Ile Tyr Glu Thr Phe Tyr Lys Leu Ile Lys Ile Phe Gln Glu His Pro 
         835                840                845
Leu His Gly Cys Ser Val Ser Asn Asp Ser Glu Ala Asp Ser Ser Ser 
     850                855                860
Asn Asn Met Thr Trp Ala Ala Thr Thr Leu Ala Pro Asp Asn Ser Ser 
 865                870                875                880
Ala Ser Gly Gln Glu Arg Pro Arg Gly Gln Pro Asn Thr Ala Leu Leu 
                 885                890                895
Ser Leu Val Leu Met Ala Gly Thr Phe Phe Ile Ala Phe Phe Leu Arg 
             900                905                910
Lys Phe Lys Asn Ser Arg Phe Phe Pro Gly Arg Ile Arg Arg Val Ile 
         915                920                925
Gly Asp Phe Gly Val Pro Ile Ala Ile Leu Ile Met Val Leu Val Asp 
     930                935                940
Tyr Ser Ile Glu Asp Thr Tyr Thr Gln Lys Leu Ser Val Pro Ser Gly 
 945                950                955                960
Phe Ser Val Thr Ala Pro Asp Lys Arg Gly Trp Val Ile Asn Pro Leu 
                 965                970                975
Gly Glu Lys Thr Pro Phe Pro Val Trp Met Met Val Ala Ser Leu Leu 
             980                985                990
Pro Ala Val Leu Val Phe Ile Leu Ile Phe Met Glu Thr Gln Ile Thr 
         995                1000                1005
Thr Leu Ile Ile Ser Lys Lys Glu Arg Met Leu Gln Lys Gly Ser Gly 
     1010                1015                1020
Phe His Leu Asp Leu Leu Leu Ile Val Ala Met Gly Gly Ile Cys Ala 
 1025                1030                1035                1040
Leu Phe Gly Leu Pro Trp Leu Ala Ala Ala Thr Val Arg Ser Val Thr 
                 1045                1050                1055
His Ala Asn Ala Leu Thr Val Met Ser Lys Ala Val Ala Pro Gly Asp 
             1060                1065                1070
Lys Pro Lys Ile Gln Glu Val Lys Glu Gln Arg Val Thr Gly Leu Leu 
         1075                1080                1085
Val Ala Leu Leu Val Gly Leu Ser Met Val Ile Gly Asp Leu Leu Arg 
     1090                1095                1100
Gln Ile Pro Leu Ala Val Leu Phe Gly Ile Phe Leu Tyr Met Gly Val 
 1105                1110                1115                1120
Thr Ser Leu Asn Gly Ile Gln Phe Tyr Glu Arg Leu His Leu Leu Leu 
                 1125                1130                1135
Met Pro Pro Lys His His Pro Asp Val Thr Tyr Val Lys Lys Val Arg 
             1140                1145                1150
Thr Met Arg Met His Leu Phe Thr Ala Leu Gln Leu Leu Cys Leu Ala 
         1155                1160                1165
Leu Leu Trp Ala Val Met Ser Thr Ala Ala Ser Leu Ala Phe Pro Phe 
     1170                1175                1180
Ile Leu Ile Leu Thr Val Pro Leu Arg Met Val Val Leu Thr Arg Ile 
 1185                1190                1195                1200
Phe Thr Glu Arg Glu Met Lys Cys Leu Asp Ala Asn Glu Ala Glu Pro 
                 1205                1210                1215
Val Phe Asp Glu Cys Glu Gly Val Asp Glu Tyr Asn Glu Met Pro Met 
             1220                1225                1230
Pro Val 
         1235



<210> 2619
<211> 4269
<212> DNA
<213> Rattus norvegicus
<308> J05210
<400> 2619

taagctggt  cttacggac  gagagccac  ctcgggctt  ctcgaagag  taaaccagg  60
ccctctgca  ccatgtcag  caaggcaat  tcagagcag  ccggcaaag  actccttta  120
aagtacatc  gtaccacct  agccatcca  aaccggttc  agtatgccc  ggttactcc  180
gacacagac  gggcccatc  cctgcagga  cacccctgg  tgcttagcc  gagcttggt  240
gtcaagccg  accagctga  caaacgtcg  ggaaagctt  gtctagtcg  ggtcaacct  300
tctctggat  gagtcaaat  ctggctgaa  cctcgactg  gacatgagg  caccgtcgg  360
aaggccaaa  gcttcctca  gaactttct  attgagccc  tcgtccccc  cagtcaggc  420
gaggagttc  acgtgtgca  ctatgctac  cgggaagga  actacgtcc  gttccacca  480
gaagggggt  tggatgtgg  cgatgtgga  accaaagcc  agaagctgc  tgtgggtgt  540
gacgagaaa  tgaacgctg  agacattaa  agacacctg  tggtccacg  ccccgaaga  600
aagaaagaa  tcctggcca  cttcatctc  ggcctattc  atttctacg  agatcttta  660
ttcacctac  ttgagatca  cccccttgt  gtgaccaaa  atggtgtct  catccttga  720
ctggcggcc  aggtggacg  cactgctga  tacatctgc  aagtcaagt  gggtgatat  780
gagttccct  ccccctttg  gcgtgaggc  tacccagag  aagcctaca  tgcagacct  840
gatgccaaa  gtggggcga  cttgaagct  accttgctg  accccaagg  gcggatctg  900
accatggtt  ccgggggtg  cgcctctgt  gtgtacagt  ataccatct  tgatcttgg  960
ggtgtcaac  aactggcga  ttacgggga  tactctggt  cccccagtg  acaacagac  1020
tatgactac  ccaagacca  cctctcact  atgactcga  agaagcacc  ggatggcaa  1080
atcctcatc  ttggaggca  cattgcaaa  ttcaccaac  tggccgcca  cttcaaggg  1140
attgtgaga  caattcgag  ttaccaggg  tccctgaag  agcacgagg  caccatctt  1200
gttcgaaga  gtggcccga  ctatcaaga  ggattacga  tgatgggag  agttgggaa  1260
accactgga  tccccatcc  tgtctttgg  acagaaact  acatgacgg  cattgtggg  1320
atggcctgg  caccggcca  tcccaacca  ccacccaca  cggctcaca  tgccaactt  1380
ctccttaat  ccagtggga  cacatcgac  ccagcaccc  gcaggacag  gtctttttc  1440
gagtccaga  ctgacgagg  ggcccctgc  aagaaagcc  agccagcca  gccccaaga  1500
tcagtccca  gtccaagat  cctgcaagg  aagagtgcc  ccctcttca  ccgacatac  1560
aaggctatc  tatggggca  gcagacccg  gctgtgcaa  gcatgctgg  ctttgacta  1620
gtgtgctcc  gagatgagc  ttcagtggc  gctatggtc  acccgttca  gggggatca  1680
aagcagaag  tttactggg  acacaagga  atcctgatc  ctgtcttca  gaacatggc  1740
gacgccatg  aaaagcatc  ggaggtaga  gtgctgatc  actttgcat  tctgcgatc  1800
gcttatgac  gcaccatgg  gaccatgaa  tatgcacag  tccggacca  agccatcat  1860
gcagaaggc  tccctgagg  tctcacacg  aagctcatc  agaaggcag  ccagaaggg  1920
gtgaccatc  ttgggccag  cacggttgg  ggcatcaag  ctggatgct  taagattgg  1980
aatactggt  ggatgctgg  caacatcct  gcctccaaa  tgtatcgcc  aggcagtgt  2040
gcctacgtc  cgcgttcag  aggcatgtc  aacgaactc  ataatatca  ctctcggac  2100
acagatggt  tctacgagg  tgttgccat  ggcggggac  ggtaccctg  gtccacatt  2160
atggatcac  tgctgcgtt  ccaagacac  ccaggagtc  agatgattg  agttcttgg  2220
gagataggg  gtacagaag  atataagat  tgccggggc  tcaaggagg  ccgcctcac  2280
aagccagtg  tctgctggt  catcgggac  tgtgccacc  tgttctctt  tgaggtcca  2340
tttggccac  ctggggctt  tgccaacca  gcttctgaa  cggcagtag  caagaacca  2400
gccttgaag  aagcgggag  gtttgtgcc  cgaagcttt  atgagctcg  agaaatcat  2460
cagtccgtg  atgaagatc  tgtggccaa  ggcgccatt  tacctgctc  ggaagtgcc  2520
cctccaaca  tacccatgg  ctactcttg  gccagggag  tgggtttaa  ccgaaaacc  2580
gcctcattc  tgaccagca  ctgtgacga  cgggggcag  aactcattt  tgcgggcat  2640
cccatcacc  aggtcttca  ggaagagat  ggcattggt  gtgtcctgg  cctcctctg  2700
ttccagaga  ggttgccca  gtattcctg  cagttcatt  agatgtgtc  catggtcac  2760
gctgatcac  ggccagctg  ctccggggc  cataacact  tcatctgtg  tcgggctgg  2820
aaggacctg  tctccagcc  cacctcagg  ctgctcacc  ttggggacc  gtttggggg  2880
gccttggac  cagcagcga  gatgttcag  aaagccttt  acagcggca  tattcccat  2940
gagtttgtg  acaagatga  gaaggaggg  aaactgatc  tgggcatcg  ccatcgagt  3000
aaatcgata  acaacccag  catgcgagt  cagatcctc  aagactttg  caaacagca  3060
ttccccgcc  ccccgctgc  cgactatgc  ctggaagtg  agaaaatca  cacctcaaa  3120
aagccaaat  ttatcctga  cgtggatgg  ttcatcggc  ttgcgtttg  ggacatgct  3180
aggaactgt  gctccttca  ccgggagga  gctgacgag  atgttgaca  tggagccct  3240
aatggcgtc  ttgtgctgg  aaggagtat  ggcttcatc  ggcactatc  tgaccagaa  3300
aggctgaag  aagggctgt  tcgtcaccc  tgggacgac  tttcctatg  tctcccgga  3360
cacatgagc  tgtaaccga  ccagcagcc  taccgtaga  aaaggaaga  aaaaactcc  3420
tcctcgaca  tatagcgga  agacagctg  aaacagagc  cgttatggg  tgggcctgg  3480
atggaaata  ccattgatg  gcaggcatg  aaagccaac  ccacaggcc  attcagtcc  3540
cacagagaa  cttagtatt  ttttttata  atatatcta  atatatata  gcatagaaa  3600
ttaaaacca  gccaatact  gtgacgttt  cgctgctac  tgctgtatc  attacatgg  3660
agactgtaa  caagcgctg  cagaataat  ttcttctag  gccttatga  gttgctttc  3720
ttttttaat  agttgaaaa  ttatttttc  tctagaact  gtggatccg  cttttaaga  3780
ttcaggata  tatctgttt  taggaccac  gtctggtat  ccacctccc  ctcatcttc  3840
caccacatg  agaacactg  attaatctg  ttttttagg  tcttttttt  tttttttgt  3900
ttatgtgtt  agggtttat  tagtatccc  ctgaaacgt  ctgtgtttc  gaccaatgt  3960
tacttatgt  aaggggagg  gggttgggg  cattgtacc  ttagccatc  tcacacatg  4020
ggagtagta  cttaaatgt  aagttgtaa  atacaagtg  ttaaaatgg  aaccgcaaa  4080
caaaaagct  tgaaacgtc  cgtgtcttg  gttctctgt  ttcatgcag  tgacttgtc  4140
gttactgaa  tgtgggtcc  aagactcac  tctgttccg  atctgtaac  cacagagat  4200
ctggcagct  ccacctcag  ctcttctct  tattatcat  tttggttta  ataaactag  4260
tagtaaaaa  4269



<210> 2620
<211> 1100
<212> PRT
<213> Rattus norvegicus
<308> P16638
<400> 2620

Met Ser Ala Lys Ala Ile Ser Glu Gln Thr Gly Lys Glu Leu Leu Tyr 
  1               5                  10                  15
Lys Tyr Ile Cys Thr Thr Ser Ala Ile Gln Asn Arg Phe Lys Tyr Ala 
             20                  25                  30
Arg Val Thr Pro Asp Thr Asp Trp Ala His Leu Leu Gln Asp His Pro 
         35                  40                  45
Trp Leu Leu Ser Gln Ser Leu Val Val Lys Pro Asp Gln Leu Ile Lys 
     50                  55                  60
Arg Arg Gly Lys Leu Gly Leu Val Gly Val Asn Leu Ser Leu Asp Gly 
 65                  70                  75                  80
Val Lys Ser Trp Leu Lys Pro Arg Leu Gly His Glu Ala Thr Val Gly 
                 85                  90                  95
Lys Ala Lys Gly Phe Leu Lys Asn Phe Leu Ile Glu Pro Phe Val Pro 
             100                105                110
His Ser Gln Ala Glu Glu Phe Tyr Val Cys Ile Tyr Ala Thr Arg Glu 
         115                120                125
Gly Asp Tyr Val Leu Phe His His Glu Gly Gly Val Asp Val Gly Asp 
     130                135                140
Val Asp Thr Lys Ala Gln Lys Leu Leu Val Gly Val Asp Glu Lys Leu 
 145                150                155                160
Asn Ala Glu Asp Ile Lys Arg His Leu Leu Val His Ala Pro Glu Asp 
                 165                170                175
Lys Lys Glu Ile Leu Ala Ser Phe Ile Ser Gly Leu Phe Asn Phe Tyr 
             180                185                190
Glu Asp Leu Tyr Phe Thr Tyr Leu Glu Ile Asn Pro Leu Val Val Thr 
         195                200                205
Lys Asp Gly Val Tyr Ile Leu Asp Leu Ala Ala Lys Val Asp Ala Thr 
     210                215                220
Ala Asp Tyr Ile Cys Lys Val Lys Trp Gly Asp Ile Glu Phe Pro Pro 
 225                230                235                240
Pro Phe Gly Arg Glu Ala Tyr Pro Glu Glu Ala Tyr Ile Ala Asp Leu 
                 245                250                255
Asp Ala Lys Ser Gly Ala Ser Leu Lys Leu Thr Leu Leu Asn Pro Lys 
             260                265                270
Gly Arg Ile Trp Thr Met Val Ala Gly Gly Gly Ala Ser Val Val Tyr 
         275                280                285
Ser Asp Thr Ile Cys Asp Leu Gly Gly Val Asn Glu Leu Ala Asn Tyr 
     290                295                300
Gly Glu Tyr Ser Gly Ala Pro Ser Glu Gln Gln Thr Tyr Asp Tyr Ala 
 305                310                315                320
Lys Thr Ile Leu Ser Leu Met Thr Arg Glu Lys His Pro Asp Gly Lys 
                 325                330                335
Ile Leu Ile Ile Gly Gly Ser Ile Ala Asn Phe Thr Asn Val Ala Ala 
             340                345                350
Thr Phe Lys Gly Ile Val Arg Ala Ile Arg Asp Tyr Gln Gly Ser Leu 
         355                360                365
Lys Glu His Glu Val Thr Ile Phe Val Arg Arg Gly Gly Pro Asn Tyr 
     370                375                380
Gln Glu Gly Leu Arg Val Met Gly Glu Val Gly Lys Thr Thr Gly Ile 
 385                390                395                400
Pro Ile His Val Phe Gly Thr Glu Thr His Met Thr Ala Ile Val Gly 
                 405                410                415
Met Ala Trp Ala Pro Ala Ile Pro Asn Gln Pro Pro Thr Ala Ala His 
             420                425                430
Thr Ala Asn Phe Leu Leu Asn Ala Ser Gly Ser Thr Ser Thr Pro Ala 
         435                440                445
Pro Ser Arg Thr Ala Ser Phe Ser Glu Ser Arg Ala Asp Glu Val Ala 
     450                455                460
Pro Ala Lys Lys Ala Lys Pro Ala Met Pro Gln Asp Ser Val Pro Ser 
 465                470                475                480
Pro Arg Ser Leu Gln Gly Lys Ser Ala Thr Leu Phe Ser Arg His Thr 
                 485                490                495
Lys Ala Ile Val Trp Gly Met Gln Thr Arg Ala Val Gln Gly Met Leu 
             500                505                510
Asp Phe Asp Tyr Val Cys Ser Arg Asp Glu Pro Ser Val Ala Ala Met 
         515                520                525
Val Tyr Pro Phe Thr Gly Asp His Lys Gln Lys Phe Tyr Trp Gly His 
     530                535                540
Lys Glu Ile Leu Ile Pro Val Phe Lys Asn Met Ala Asp Ala Met Lys 
 545                550                555                560
Lys His Pro Glu Val Asp Val Leu Ile Asn Phe Ala Ser Leu Arg Ser 
                 565                570                575
Ala Tyr Asp Ser Thr Met Glu Thr Met Asn Tyr Ala Gln Ile Arg Thr 
             580                585                590
Ile Ala Ile Ile Ala Glu Gly Ile Pro Glu Ala Leu Thr Arg Lys Leu 
         595                600                605
Ile Lys Lys Ala Asp Gln Lys Gly Val Thr Ile Ile Gly Pro Ala Thr 
     610                615                620
Val Gly Gly Ile Lys Pro Gly Cys Phe Lys Ile Gly Asn Thr Gly Gly 
 625                630                635                640
Met Leu Asp Asn Ile Leu Ala Ser Lys Leu Tyr Arg Pro Gly Ser Val 
                 645                650                655
Ala Tyr Val Ser Arg Ser Gly Gly Met Ser Asn Glu Leu Asn Asn Ile 
             660                665                670
Ile Ser Arg Thr Thr Asp Gly Val Tyr Glu Gly Val Ala Ile Gly Gly 
         675                680                685
Asp Arg Tyr Pro Gly Ser Thr Phe Met Asp His Val Leu Arg Tyr Gln 
     690                695                700
Asp Thr Pro Gly Val Lys Met Ile Val Val Leu Gly Glu Ile Gly Gly 
 705                710                715                720
Thr Glu Glu Tyr Lys Ile Cys Arg Gly Ile Lys Glu Gly Arg Leu Thr 
                 725                730                735
Lys Pro Val Val Cys Trp Cys Ile Gly Thr Cys Ala Thr Met Phe Ser 
             740                745                750
Ser Glu Val Gln Phe Gly His Ala Gly Ala Cys Ala Asn Gln Ala Ser 
         755                760                765
Glu Thr Ala Val Ala Lys Asn Gln Ala Leu Lys Glu Ala Gly Val Phe 
     770                775                780
Val Pro Arg Ser Phe Asp Glu Leu Gly Glu Ile Ile Gln Ser Val Tyr 
 785                790                795                800
Glu Asp Leu Val Ala Lys Gly Ala Ile Val Pro Ala Gln Glu Val Pro 
                 805                810                815
Pro Pro Thr Val Pro Met Asp Tyr Ser Trp Ala Arg Glu Leu Gly Leu 
             820                825                830
Ile Arg Lys Pro Ala Ser Phe Met Thr Ser Ile Cys Asp Glu Arg Gly 
         835                840                845
Gln Glu Leu Ile Tyr Ala Gly Met Pro Ile Thr Glu Val Phe Lys Glu 
     850                855                860
Glu Met Gly Ile Gly Gly Val Leu Gly Leu Leu Trp Phe Gln Arg Arg 
 865                870                875                880
Leu Pro Lys Tyr Ser Cys Gln Phe Ile Glu Met Cys Leu Met Val Thr 
                 885                890                895
Ala Asp His Gly Pro Ala Val Ser Gly Ala His Asn Thr Ile Ile Cys 
             900                905                910
Ala Arg Ala Gly Lys Asp Leu Val Ser Ser Leu Thr Ser Gly Leu Leu 
         915                920                925
Thr Ile Gly Asp Arg Phe Gly Gly Ala Leu Asp Ala Ala Ala Lys Met 
     930                935                940
Phe Ser Lys Ala Phe Asp Ser Gly Ile Ile Pro Met Glu Phe Val Asn 
 945                950                955                960
Lys Met Lys Lys Glu Gly Lys Leu Ile Met Gly Ile Gly His Arg Val 
                 965                970                975
Lys Ser Ile Asn Asn Pro Asp Met Arg Val Gln Ile Leu Lys Asp Phe 
             980                985                990
Val Lys Gln His Phe Pro Ala Thr Pro Leu Leu Asp Tyr Ala Leu Glu 
         995                1000                1005
Val Glu Lys Ile Thr Thr Ser Lys Lys Pro Asn Leu Ile Leu Asn Val 
     1010                1015                1020
Asp Gly Phe Ile Gly Val Ala Phe Val Asp Met Leu Arg Asn Cys Gly 
 1025                1030                1035                1040
Ser Phe Thr Arg Glu Glu Ala Asp Glu Tyr Val Asp Ile Gly Ala Leu 
                 1045                1050                1055
Asn Gly Val Phe Val Leu Gly Arg Ser Met Gly Phe Ile Gly His Tyr 
             1060                1065                1070
Leu Asp Gln Lys Arg Leu Lys Gln Gly Leu Tyr Arg His Pro Trp Asp 
         1075                1080                1085
Asp Ile Ser Tyr Val Leu Pro Glu His Met Ser Met 
     1090                1095                1100



<210> 2621
<211> 4297
<212> DNA
<213> Homo sapiens
<308> X64330
<400> 2621

cccggattt  gcggggttc  tcgggcctg  ggaagaagc  ccgccacgg  cttcggcag  60
ggtagagca  gtctctctg  agccatgtc  gccaaggca  tttcagagc  gacgggcaa  120
gaactcctt  acaagttca  ctgtaccac  tcagccatc  agaatcggt  caagtatgc  180
cgggtcact  ctgacacag  ctgggcccg  ttgctgcag  accacccct  gctgctcag  240
cagaacttg  tagtcaagc  agaccagct  atcaaacgt  gtggaaaac  tggtctcgt  300
ggggtcgac  tcactctgg  tggggtcaa  tcctggctg  agccacggc  gggacagga  360
gccacagtt  gcaaggcca  aggcttcct  aagaacttt  tgatcgagc  cttcgcccc  420
cacagtcag  ctgaggagt  ctatgtctg  atctatgcc  cccgagaag  ggactacgt  480
ctgttccac  acgaggggg  tgtggacgt  ggtgatgtg  acgccaagg  ccagaagct  540
cttgttggc  tggatgaga  actgaatcc  gaggacatc  aaaaacacc  gttggtcca  600
gcccctgac  acaagaaag  aattctggc  agttttatc  ccggcctct  caatttcta  660
gaggacttg  acttcacct  cctcgagat  aatcccctt  tagtgacca  agatggagt  720
tatgtcctt  acttggcgg  caaggtgga  gccactgcc  actacatct  caaagtgaa  780
tggggtgac  tcgagttcc  tcccccctt  gggcgggtg  catatccag  ggaagccta  840
attgcagac  tcgatgcca  aagtggggc  agcctgaag  tgaccttgc  gaaccccaa  900
gggaggatc  ggaccatgg  ggccggggg  ggcgcctct  tcgtgtaca  cgataccat  960
tgtgatcta  ggggtgtca  cgagctggc  aactatggg  agtactcag  cgcccccag  1020
gagcagcag  cctatgact  tgccaagac  atcctctcc  tcatgaccc  agagaagca  1080
ccagatggc  agatcctca  cattggagg  agcatcgca  acttcacca  cgtggctgc  1140
acgttcaag  gcatcgtga  agcaattcg  gattaccag  gccccctga  ggagcacga  1200
gtcacaatc  ttgtccgaa  aggtggccc  aactatcag  agggcttac  ggtgatggg  1260
gaagtcggg  agaccactg  gatccccat  catgtcttt  gcacagaga  tcacatgac  1320
gccattgtg  gcatggcct  ggcaccggc  atccccaac  agccaccca  agcggccca  1380
actgcaaac  ttctcctca  cgcccagcg  gagacatcg  ctccagccc  cagcaggac  1440
gcatctttt  atgagtcca  ggtcgatga  gtcagggcc  atgaggtgg  gcctgcaaa  1500
aaggccaag  ctgccatgc  acaagattc  gtcccaagt  caagatccc  gcaaggaaa  1560
agcaccacc  tcttcagcc  ccacaccaa  gccattgtg  ggggcatgc  gacccgggc  1620
gtgcaaggc  tgctggact  tgactatgt  tgctcccga  acgagccct  agtggctgc  1680
atggtctat  ctttcactg  ggaccacaa  cagaagttt  actgggggc  caaagagat  1740
ctgatccct  tcttcaaga  catggctga  gccatgagg  agcacccgg  ggtagatgt  1800
ctcatcaac  ttgcctctc  ccgctctgc  tatgacagc  ccatggaga  catgaacta  1860
gcccagatc  ggaccatcg  catcatagc  gaaggcatc  ctgaggccc  cacgagaaa  1920
ctgatcaag  aggcggacc  gaagggagt  accatcatc  gacctgcca  tgttggagg  1980
atcaagcct  ggtgcttta  gattggcaa  acaggtggg  tgctggaca  catcctggc  2040
tccaaactg  acccccagg  agctgtggc  tatgtctca  gttccggag  catgtccaa  2100
gagctcaac  atatcatct  tcggaccac  gatggcgtc  atgagggcg  ggccattgg  2160
ggggacagg  acccgggct  cacattcat  gatcatgtg  tacgctatc  ggacactcc  2220
ggagtcaaa  tgattgtgg  tcttggaga  attgggggc  ctgaggaat  taagatttc  2280
cggggcatc  aggagggcc  cctcactaa  cccatcgtc  gctggtgca  cgggacgtg  2340
gccaccatg  tctcctctg  ggtccagtt  ggccatgct  gagcttgtg  caaccaggc  2400
tctgaaact  cagtagcca  gaaccaggc  ttgaaggaa  caggagtgt  tgtgccccg  2460
agctttgat  agcttggag  gatcatcca  tctgtatac  aagatctcg  ggccaatgg  2520
gtcattgta  ctgcccagg  ggtgccgcc  ccaaccgtg  ccatggact  ctcctgggc  2580
agggagctt  gtttgatcc  caaacctgc  tcgttcatg  ccagcatct  cgatgagcg  2640
ggacaggag  tcatctacg  gggcatgcc  atcactgag  tcttcaagg  agagatggg  2700
attggcggg  ccctcggcc  cctctggtt  cagaaaagg  tgcctaagt  ctcttgcca  2760
ttcattgag  tgtgtctga  ggtgacagc  gatcacggg  cagccgtct  tggagccca  2820
aacaccatc  tttgtgcgc  caccgcggt  gagctggtc  ccagcctca  ctcggggct  2880
ctcaccatc  gggatcggt  tgggggtgc  ttggatgca  cagccaaga  gttcagtaa  2940
gcctttgac  gtggcatta  ccccatgga  tttgtgaac  agatgaaga  ggaagggaa  3000
ctgatcatg  gcattggtc  ccgagtgaa  tcgataaac  acccagaca  gcgagtgca  3060
atcctcaaa  attacgtca  gcagcactt  cctgccact  ctctgctcg  ttatgcact  3120
gaagtagag  agattacca  ctcgaagaa  ccaaatctt  tcctgaatg  agatggtct  3180
atcggagtc  catttgtag  catgcttag  aactgtggg  cctttactc  ggaggaagc  3240
gatgaatat  ttgacattg  agccctcaa  ggcatcttt  tgctgggaa  gagtatggg  3300
ttcattgga  actatcttg  tcagaagag  ctgaagcag  ggctgtatc  tcatccgtg  3360
gatgatatt  catatgttc  tccggaaca  atgagcatg  aacagagcc  ggaacccta  3420
tgcagtaaa  tgaagacaa  aactcttcc  ccaagaaaa  gtgtcagac  gctggcagt  3480
gagcctgct  tatttagca  gggcctgga  tgtaaacag  cactggggt  caggcaccg  3540
agaccaaca  ccacaggct  acacccctt  agtccacac  aagaagctt  atatttttt  3600
tataagcat  gaaataaaa  ccaagccaa  atttgtgac  ttgctctgc  acctgctgt  3660
tttattata  ggaagcatc  aagtactgt  aggatgggg  cttcctcat  gtagggcgt  3720
aggatgttg  tttcttttt  cattagtta  acatttttt  ctcctttgg  ggaagggaa  3780
gaaacattt  tggcctcaa  atactatac  tttaaagca  cccaatgtc  ctctttttt  3840
tttttttta  ttcccttgc  tcttcctta  ataacatga  gaacattgt  ttaatctga  3900
ttttaaaga  tttttgtat  ttacgtgtt  agggcttgt  tggtatccc  ctgaaatgt  3960
ctgtgttgc  gaccagagt  tgtttatgt  agggggagg  ggccattgc  tccttagcc  4020
ttgtcacaa  atatgtgga  tagtaactt  atatgtaaa  ttgtaacat  catacattt  4080
aaatggaaa  gcagaaagc  gtgaaatgt  ttgtgtctt  tgttctctg  atttatgca  4140
ctgatttgt  tgtctgtaa  tgaagtgtg  gtccaagga  tcctaacta  tttgcatct  4200
taatccaca  agattctgg  cagctgcca  ctcagtctc  tctctgtat  atcatagtc  4260
ggtttaaat  aactatata  taacaggaa  tcctgca  4297



<210> 2622
<211> 1101
<212> PRT
<213> Homo sapiens
<308> P53396
<400> 2622

Met Ser Ala Lys Ala Ile Ser Glu Gln Thr Gly Lys Glu Leu Leu Tyr 
  1               5                  10                  15
Lys Phe Ile Cys Thr Thr Ser Ala Ile Gln Asn Arg Phe Lys Tyr Ala 
             20                  25                  30
Arg Val Thr Pro Asp Thr Asp Trp Ala Arg Leu Leu Gln Asp His Pro 
         35                  40                  45
Trp Leu Leu Ser Gln Asn Leu Val Val Lys Pro Asp Gln Leu Ile Lys 
     50                  55                  60
Arg Arg Gly Lys Leu Gly Leu Val Gly Val Asn Leu Thr Leu Asp Gly 
 65                  70                  75                  80
Val Lys Ser Trp Leu Lys Pro Arg Leu Gly Gln Glu Ala Thr Val Gly 
                 85                  90                  95
Lys Ala Thr Gly Phe Leu Lys Asn Phe Leu Ile Glu Pro Phe Val Pro 
             100                105                110
His Ser Gln Ala Glu Glu Phe Tyr Val Cys Ile Tyr Ala Thr Arg Glu 
         115                120                125
Gly Asp Tyr Val Leu Phe His His Glu Gly Gly Val Asp Val Gly Asp 
     130                135                140
Val Asp Ala Lys Ala Gln Lys Leu Leu Val Gly Val Asp Glu Lys Leu 
 145                150                155                160
Asn Pro Glu Asp Ile Lys Lys His Leu Leu Val His Ala Pro Asp Asp 
                 165                170                175
Lys Lys Glu Ile Leu Ala Ser Phe Ile Ser Gly Leu Phe Asn Phe Tyr 
             180                185                190
Glu Asp Leu Tyr Phe Thr Tyr Leu Glu Ile Asn Pro Leu Val Val Thr 
         195                200                205
Lys Asp Gly Val Tyr Val Leu Asp Leu Ala Ala Lys Val Asp Ala Thr 
     210                215                220
Ala Asp Tyr Ile Cys Lys Val Lys Trp Gly Asp Ile Glu Phe Pro Pro 
 225                230                235                240
Pro Phe Gly Arg Glu Ala Tyr Pro Glu Glu Ala Tyr Ile Ala Asp Leu 
                 245                250                255
Asp Ala Lys Ser Gly Ala Ser Leu Lys Leu Thr Leu Leu Asn Pro Lys 
             260                265                270
Gly Arg Ile Trp Thr Met Val Ala Gly Gly Gly Ala Ser Val Val Tyr 
         275                280                285
Ser Asp Thr Ile Cys Asp Leu Gly Gly Val Asn Glu Leu Ala Asn Tyr 
     290                295                300
Gly Glu Tyr Ser Gly Ala Pro Ser Glu Gln Gln Thr Tyr Asp Tyr Ala 
 305                310                315                320
Lys Thr Ile Leu Ser Leu Met Thr Arg Glu Lys His Pro Asp Gly Lys 
                 325                330                335
Ile Leu Ile Ile Gly Gly Ser Ile Ala Asn Phe Thr Asn Val Ala Ala 
             340                345                350
Thr Phe Lys Gly Ile Val Arg Ala Ile Arg Asp Tyr Gln Gly Pro Leu 
         355                360                365
Lys Glu His Glu Val Thr Ile Phe Val Arg Arg Gly Gly Pro Asn Tyr 
     370                375                380
Gln Glu Gly Leu Arg Val Met Gly Glu Val Gly Lys Thr Thr Gly Ile 
 385                390                395                400
Pro Ile His Val Phe Gly Thr Glu Thr His Met Thr Ala Ile Val Gly 
                 405                410                415
Met Ala Leu Gly His Arg Pro Ile Pro Asn Gln Pro Pro Thr Ala Ala 
             420                425                430
His Thr Ala Asn Phe Leu Leu Asn Ala Ser Gly Ser Thr Ser Thr Pro 
         435                440                445
Ala Pro Ser Arg Thr Ala Ser Phe Ser Glu Ser Arg Ala Asp Glu Val 
     450                455                460
Ala Pro Ala Lys Lys Ala Lys Pro Ala Met Pro Gln Asp Ser Val Pro 
 465                470                475                480
Ser Pro Arg Ser Leu Gln Gly Lys Ser Thr Thr Leu Phe Ser Arg His 
                 485                490                495
Thr Lys Ala Ile Val Trp Gly Met Gln Thr Arg Ala Val Gln Gly Met 
             500                505                510
Leu Asp Phe Asp Tyr Val Cys Ser Arg Asp Glu Pro Ser Val Ala Ala 
         515                520                525
Met Val Tyr Pro Phe Thr Gly Asp His Lys Gln Lys Phe Tyr Trp Gly 
     530                535                540
His Lys Glu Ile Leu Ile Pro Val Phe Lys Asn Met Ala Asp Ala Met 
 545                550                555                560
Arg Lys His Pro Glu Val Asp Val Leu Ile Asn Phe Ala Ser Leu Arg 
                 565                570                575
Ser Ala Tyr Asp Ser Thr Met Glu Thr Met Asn Tyr Ala Gln Ile Arg 
             580                585                590
Thr Ile Ala Ile Ile Ala Glu Gly Ile Pro Glu Ala Leu Thr Arg Lys 
         595                600                605
Leu Ile Lys Lys Ala Asp Gln Lys Gly Val Thr Ile Ile Gly Pro Ala 
     610                615                620
Thr Val Gly Gly Ile Lys Pro Gly Cys Phe Lys Ile Gly Asn Thr Gly 
 625                630                635                640
Gly Met Leu Asp Asn Ile Leu Ala Ser Lys Leu Tyr Arg Pro Gly Ser 
                 645                650                655
Val Ala Tyr Val Ser Arg Ser Gly Gly Met Ser Asn Glu Leu Asn Asn 
             660                665                670
Ile Ile Ser Arg Thr Thr Asp Gly Val Tyr Glu Gly Val Ala Ile Gly 
         675                680                685
Gly Asp Arg Tyr Pro Gly Ser Thr Phe Met Asp His Val Leu Arg Tyr 
     690                695                700
Gln Asp Thr Pro Gly Val Lys Met Ile Val Val Leu Gly Glu Ile Gly 
 705                710                715                720
Gly Thr Glu Glu Tyr Lys Ile Cys Arg Gly Ile Lys Glu Gly Arg Leu 
                 725                730                735
Thr Lys Pro Ile Val Cys Trp Cys Ile Gly Thr Cys Ala Thr Met Phe 
             740                745                750
Ser Ser Glu Val Gln Phe Gly His Ala Gly Ala Cys Ala Asn Gln Ala 
         755                760                765
Ser Glu Thr Ala Val Ala Lys Asn Gln Ala Leu Lys Glu Ala Gly Val 
     770                775                780
Phe Val Pro Arg Ser Phe Asp Glu Leu Gly Glu Ile Ile Gln Ser Val 
 785                790                795                800
Tyr Glu Asp Leu Val Ala Asn Gly Val Ile Val Pro Ala Gln Glu Val 
                 805                810                815
Pro Pro Pro Thr Val Pro Met Asp Tyr Ser Trp Ala Arg Glu Leu Gly 
             820                825                830
Leu Ile Arg Lys Pro Ala Ser Phe Met Thr Ser Ile Cys Asp Glu Arg 
         835                840                845
Gly Gln Glu Leu Ile Tyr Ala Gly Met Pro Ile Thr Glu Val Phe Lys 
     850                855                860
Glu Glu Met Gly Ile Gly Gly Val Leu Gly Leu Leu Trp Phe Gln Lys 
 865                870                875                880
Arg Leu Pro Lys Tyr Ser Cys Gln Phe Ile Glu Met Cys Leu Met Val 
                 885                890                895
Thr Ala Asp His Gly Pro Ala Val Ser Gly Ala His Asn Thr Ile Ile 
             900                905                910
Cys Ala Arg Ala Gly Lys Asp Leu Val Ser Ser Leu Thr Ser Gly Leu 
         915                920                925
Leu Thr Ile Gly Asp Arg Phe Gly Gly Ala Leu Asp Ala Ala Ala Lys 
     930                935                940
Met Phe Ser Lys Ala Phe Asp Ser Gly Ile Ile Pro Met Glu Phe Val 
 945                950                955                960
Asn Lys Met Lys Lys Glu Gly Lys Leu Ile Met Gly Ile Gly His Arg 
                 965                970                975
Val Lys Ser Ile Asn Asn Pro Asp Met Arg Val Gln Ile Leu Lys Asp 
             980                985                990
Tyr Val Arg Gln His Phe Pro Ala Thr Pro Leu Leu Asp Tyr Ala Leu 
         995                1000                1005
Glu Val Glu Lys Ile Thr Thr Ser Lys Lys Pro Asn Leu Ile Leu Asn 
     1010                1015                1020
Val Asp Gly Leu Ile Gly Val Ala Phe Val Asp Met Leu Arg Asn Cys 
 1025                1030                1035                1040
Gly Ser Phe Thr Arg Glu Glu Ala Asp Glu Tyr Ile Asp Ile Gly Ala 
                 1045                1050                1055
Leu Asn Gly Ile Phe Val Leu Gly Arg Ser Met Gly Phe Ile Gly His 
             1060                1065                1070
Tyr Leu Asp Gln Lys Arg Leu Lys Gln Gly Leu Tyr Arg His Pro Trp 
         1075                1080                1085
Asp Asp Ile Ser Tyr Val Leu Pro Glu His Met Ser Met 
     1090                1095                1100



<210> 2623
<211> 4269
<212> DNA
<213> Rattus norvegicus
<308> J05210
<400> 2623

taagctggt  cttacggac  gagagccac  ctcgggctt  ctcgaagag  taaaccagg  60
ccctctgca  ccatgtcag  caaggcaat  tcagagcag  ccggcaaag  actccttta  120
aagtacatc  gtaccacct  agccatcca  aaccggttc  agtatgccc  ggttactcc  180
gacacagac  gggcccatc  cctgcagga  cacccctgg  tgcttagcc  gagcttggt  240
gtcaagccg  accagctga  caaacgtcg  ggaaagctt  gtctagtcg  ggtcaacct  300
tctctggat  gagtcaaat  ctggctgaa  cctcgactg  gacatgagg  caccgtcgg  360
aaggccaaa  gcttcctca  gaactttct  attgagccc  tcgtccccc  cagtcaggc  420
gaggagttc  acgtgtgca  ctatgctac  cgggaagga  actacgtcc  gttccacca  480
gaagggggt  tggatgtgg  cgatgtgga  accaaagcc  agaagctgc  tgtgggtgt  540
gacgagaaa  tgaacgctg  agacattaa  agacacctg  tggtccacg  ccccgaaga  600
aagaaagaa  tcctggcca  cttcatctc  ggcctattc  atttctacg  agatcttta  660
ttcacctac  ttgagatca  cccccttgt  gtgaccaaa  atggtgtct  catccttga  720
ctggcggcc  aggtggacg  cactgctga  tacatctgc  aagtcaagt  gggtgatat  780
gagttccct  ccccctttg  gcgtgaggc  tacccagag  aagcctaca  tgcagacct  840
gatgccaaa  gtggggcga  cttgaagct  accttgctg  accccaagg  gcggatctg  900
accatggtt  ccgggggtg  cgcctctgt  gtgtacagt  ataccatct  tgatcttgg  960
ggtgtcaac  aactggcga  ttacgggga  tactctggt  cccccagtg  acaacagac  1020
tatgactac  ccaagacca  cctctcact  atgactcga  agaagcacc  ggatggcaa  1080
atcctcatc  ttggaggca  cattgcaaa  ttcaccaac  tggccgcca  cttcaaggg  1140
attgtgaga  caattcgag  ttaccaggg  tccctgaag  agcacgagg  caccatctt  1200
gttcgaaga  gtggcccga  ctatcaaga  ggattacga  tgatgggag  agttgggaa  1260
accactgga  tccccatcc  tgtctttgg  acagaaact  acatgacgg  cattgtggg  1320
atggcctgg  caccggcca  tcccaacca  ccacccaca  cggctcaca  tgccaactt  1380
ctccttaat  ccagtggga  cacatcgac  ccagcaccc  gcaggacag  gtctttttc  1440
gagtccaga  ctgacgagg  ggcccctgc  aagaaagcc  agccagcca  gccccaaga  1500
tcagtccca  gtccaagat  cctgcaagg  aagagtgcc  ccctcttca  ccgacatac  1560
aaggctatc  tatggggca  gcagacccg  gctgtgcaa  gcatgctgg  ctttgacta  1620
gtgtgctcc  gagatgagc  ttcagtggc  gctatggtc  acccgttca  gggggatca  1680
aagcagaag  tttactggg  acacaagga  atcctgatc  ctgtcttca  gaacatggc  1740
gacgccatg  aaaagcatc  ggaggtaga  gtgctgatc  actttgcat  tctgcgatc  1800
gcttatgac  gcaccatgg  gaccatgaa  tatgcacag  tccggacca  agccatcat  1860
gcagaaggc  tccctgagg  tctcacacg  aagctcatc  agaaggcag  ccagaaggg  1920
gtgaccatc  ttgggccag  cacggttgg  ggcatcaag  ctggatgct  taagattgg  1980
aatactggt  ggatgctgg  caacatcct  gcctccaaa  tgtatcgcc  aggcagtgt  2040
gcctacgtc  cgcgttcag  aggcatgtc  aacgaactc  ataatatca  ctctcggac  2100
acagatggt  tctacgagg  tgttgccat  ggcggggac  ggtaccctg  gtccacatt  2160
atggatcac  tgctgcgtt  ccaagacac  ccaggagtc  agatgattg  agttcttgg  2220
gagataggg  gtacagaag  atataagat  tgccggggc  tcaaggagg  ccgcctcac  2280
aagccagtg  tctgctggt  catcgggac  tgtgccacc  tgttctctt  tgaggtcca  2340
tttggccac  ctggggctt  tgccaacca  gcttctgaa  cggcagtag  caagaacca  2400
gccttgaag  aagcgggag  gtttgtgcc  cgaagcttt  atgagctcg  agaaatcat  2460
cagtccgtg  atgaagatc  tgtggccaa  ggcgccatt  tacctgctc  ggaagtgcc  2520
cctccaaca  tacccatgg  ctactcttg  gccagggag  tgggtttaa  ccgaaaacc  2580
gcctcattc  tgaccagca  ctgtgacga  cgggggcag  aactcattt  tgcgggcat  2640
cccatcacc  aggtcttca  ggaagagat  ggcattggt  gtgtcctgg  cctcctctg  2700
ttccagaga  ggttgccca  gtattcctg  cagttcatt  agatgtgtc  catggtcac  2760
gctgatcac  ggccagctg  ctccggggc  cataacact  tcatctgtg  tcgggctgg  2820
aaggacctg  tctccagcc  cacctcagg  ctgctcacc  ttggggacc  gtttggggg  2880
gccttggac  cagcagcga  gatgttcag  aaagccttt  acagcggca  tattcccat  2940
gagtttgtg  acaagatga  gaaggaggg  aaactgatc  tgggcatcg  ccatcgagt  3000
aaatcgata  acaacccag  catgcgagt  cagatcctc  aagactttg  caaacagca  3060
ttccccgcc  ccccgctgc  cgactatgc  ctggaagtg  agaaaatca  cacctcaaa  3120
aagccaaat  ttatcctga  cgtggatgg  ttcatcggc  ttgcgtttg  ggacatgct  3180
aggaactgt  gctccttca  ccgggagga  gctgacgag  atgttgaca  tggagccct  3240
aatggcgtc  ttgtgctgg  aaggagtat  ggcttcatc  ggcactatc  tgaccagaa  3300
aggctgaag  aagggctgt  tcgtcaccc  tgggacgac  tttcctatg  tctcccgga  3360
cacatgagc  tgtaaccga  ccagcagcc  taccgtaga  aaaggaaga  aaaaactcc  3420
tcctcgaca  tatagcgga  agacagctg  aaacagagc  cgttatggg  tgggcctgg  3480
atggaaata  ccattgatg  gcaggcatg  aaagccaac  ccacaggcc  attcagtcc  3540
cacagagaa  cttagtatt  ttttttata  atatatcta  atatatata  gcatagaaa  3600
ttaaaacca  gccaatact  gtgacgttt  cgctgctac  tgctgtatc  attacatgg  3660
agactgtaa  caagcgctg  cagaataat  ttcttctag  gccttatga  gttgctttc  3720
ttttttaat  agttgaaaa  ttatttttc  tctagaact  gtggatccg  cttttaaga  3780
ttcaggata  tatctgttt  taggaccac  gtctggtat  ccacctccc  ctcatcttc  3840
caccacatg  agaacactg  attaatctg  ttttttagg  tcttttttt  tttttttgt  3900
ttatgtgtt  agggtttat  tagtatccc  ctgaaacgt  ctgtgtttc  gaccaatgt  3960
tacttatgt  aaggggagg  gggttgggg  cattgtacc  ttagccatc  tcacacatg  4020
ggagtagta  cttaaatgt  aagttgtaa  atacaagtg  ttaaaatgg  aaccgcaaa  4080
caaaaagct  tgaaacgtc  cgtgtcttg  gttctctgt  ttcatgcag  tgacttgtc  4140
gttactgaa  tgtgggtcc  aagactcac  tctgttccg  atctgtaac  cacagagat  4200
ctggcagct  ccacctcag  ctcttctct  tattatcat  tttggttta  ataaactag  4260
tagtaaaaa  4269



<210> 2624
<211> 1100
<212> PRT
<213> Rattus norvegicus
<308> P16638
<400> 2624

Met Ser Ala Lys Ala Ile Ser Glu Gln Thr Gly Lys Glu Leu Leu Tyr 
  1               5                  10                  15
Lys Tyr Ile Cys Thr Thr Ser Ala Ile Gln Asn Arg Phe Lys Tyr Ala 
             20                  25                  30
Arg Val Thr Pro Asp Thr Asp Trp Ala His Leu Leu Gln Asp His Pro 
         35                  40                  45
Trp Leu Leu Ser Gln Ser Leu Val Val Lys Pro Asp Gln Leu Ile Lys 
     50                  55                  60
Arg Arg Gly Lys Leu Gly Leu Val Gly Val Asn Leu Ser Leu Asp Gly 
 65                  70                  75                  80
Val Lys Ser Trp Leu Lys Pro Arg Leu Gly His Glu Ala Thr Val Gly 
                 85                  90                  95
Lys Ala Lys Gly Phe Leu Lys Asn Phe Leu Ile Glu Pro Phe Val Pro 
             100                105                110
His Ser Gln Ala Glu Glu Phe Tyr Val Cys Ile Tyr Ala Thr Arg Glu 
         115                120                125
Gly Asp Tyr Val Leu Phe His His Glu Gly Gly Val Asp Val Gly Asp 
     130                135                140
Val Asp Thr Lys Ala Gln Lys Leu Leu Val Gly Val Asp Glu Lys Leu 
 145                150                155                160
Asn Ala Glu Asp Ile Lys Arg His Leu Leu Val His Ala Pro Glu Asp 
                 165                170                175
Lys Lys Glu Ile Leu Ala Ser Phe Ile Ser Gly Leu Phe Asn Phe Tyr 
             180                185                190
Glu Asp Leu Tyr Phe Thr Tyr Leu Glu Ile Asn Pro Leu Val Val Thr 
         195                200                205
Lys Asp Gly Val Tyr Ile Leu Asp Leu Ala Ala Lys Val Asp Ala Thr 
     210                215                220
Ala Asp Tyr Ile Cys Lys Val Lys Trp Gly Asp Ile Glu Phe Pro Pro 
 225                230                235                240
Pro Phe Gly Arg Glu Ala Tyr Pro Glu Glu Ala Tyr Ile Ala Asp Leu 
                 245                250                255
Asp Ala Lys Ser Gly Ala Ser Leu Lys Leu Thr Leu Leu Asn Pro Lys 
             260                265                270
Gly Arg Ile Trp Thr Met Val Ala Gly Gly Gly Ala Ser Val Val Tyr 
         275                280                285
Ser Asp Thr Ile Cys Asp Leu Gly Gly Val Asn Glu Leu Ala Asn Tyr 
     290                295                300
Gly Glu Tyr Ser Gly Ala Pro Ser Glu Gln Gln Thr Tyr Asp Tyr Ala 
 305                310                315                320
Lys Thr Ile Leu Ser Leu Met Thr Arg Glu Lys His Pro Asp Gly Lys 
                 325                330                335
Ile Leu Ile Ile Gly Gly Ser Ile Ala Asn Phe Thr Asn Val Ala Ala 
             340                345                350
Thr Phe Lys Gly Ile Val Arg Ala Ile Arg Asp Tyr Gln Gly Ser Leu 
         355                360                365
Lys Glu His Glu Val Thr Ile Phe Val Arg Arg Gly Gly Pro Asn Tyr 
     370                375                380
Gln Glu Gly Leu Arg Val Met Gly Glu Val Gly Lys Thr Thr Gly Ile 
 385                390                395                400
Pro Ile His Val Phe Gly Thr Glu Thr His Met Thr Ala Ile Val Gly 
                 405                410                415
Met Ala Trp Ala Pro Ala Ile Pro Asn Gln Pro Pro Thr Ala Ala His 
             420                425                430
Thr Ala Asn Phe Leu Leu Asn Ala Ser Gly Ser Thr Ser Thr Pro Ala 
         435                440                445
Pro Ser Arg Thr Ala Ser Phe Ser Glu Ser Arg Ala Asp Glu Val Ala 
     450                455                460
Pro Ala Lys Lys Ala Lys Pro Ala Met Pro Gln Asp Ser Val Pro Ser 
 465                470                475                480
Pro Arg Ser Leu Gln Gly Lys Ser Ala Thr Leu Phe Ser Arg His Thr 
                 485                490                495
Lys Ala Ile Val Trp Gly Met Gln Thr Arg Ala Val Gln Gly Met Leu 
             500                505                510
Asp Phe Asp Tyr Val Cys Ser Arg Asp Glu Pro Ser Val Ala Ala Met 
         515                520                525
Val Tyr Pro Phe Thr Gly Asp His Lys Gln Lys Phe Tyr Trp Gly His 
     530                535                540
Lys Glu Ile Leu Ile Pro Val Phe Lys Asn Met Ala Asp Ala Met Lys 
 545                550                555                560
Lys His Pro Glu Val Asp Val Leu Ile Asn Phe Ala Ser Leu Arg Ser 
                 565                570                575
Ala Tyr Asp Ser Thr Met Glu Thr Met Asn Tyr Ala Gln Ile Arg Thr 
             580                585                590
Ile Ala Ile Ile Ala Glu Gly Ile Pro Glu Ala Leu Thr Arg Lys Leu 
         595                600                605
Ile Lys Lys Ala Asp Gln Lys Gly Val Thr Ile Ile Gly Pro Ala Thr 
     610                615                620
Val Gly Gly Ile Lys Pro Gly Cys Phe Lys Ile Gly Asn Thr Gly Gly 
 625                630                635                640
Met Leu Asp Asn Ile Leu Ala Ser Lys Leu Tyr Arg Pro Gly Ser Val 
                 645                650                655
Ala Tyr Val Ser Arg Ser Gly Gly Met Ser Asn Glu Leu Asn Asn Ile 
             660                665                670
Ile Ser Arg Thr Thr Asp Gly Val Tyr Glu Gly Val Ala Ile Gly Gly 
         675                680                685
Asp Arg Tyr Pro Gly Ser Thr Phe Met Asp His Val Leu Arg Tyr Gln 
     690                695                700
Asp Thr Pro Gly Val Lys Met Ile Val Val Leu Gly Glu Ile Gly Gly 
 705                710                715                720
Thr Glu Glu Tyr Lys Ile Cys Arg Gly Ile Lys Glu Gly Arg Leu Thr 
                 725                730                735
Lys Pro Val Val Cys Trp Cys Ile Gly Thr Cys Ala Thr Met Phe Ser 
             740                745                750
Ser Glu Val Gln Phe Gly His Ala Gly Ala Cys Ala Asn Gln Ala Ser 
         755                760                765
Glu Thr Ala Val Ala Lys Asn Gln Ala Leu Lys Glu Ala Gly Val Phe 
     770                775                780
Val Pro Arg Ser Phe Asp Glu Leu Gly Glu Ile Ile Gln Ser Val Tyr 
 785                790                795                800
Glu Asp Leu Val Ala Lys Gly Ala Ile Val Pro Ala Gln Glu Val Pro 
                 805                810                815
Pro Pro Thr Val Pro Met Asp Tyr Ser Trp Ala Arg Glu Leu Gly Leu 
             820                825                830
Ile Arg Lys Pro Ala Ser Phe Met Thr Ser Ile Cys Asp Glu Arg Gly 
         835                840                845
Gln Glu Leu Ile Tyr Ala Gly Met Pro Ile Thr Glu Val Phe Lys Glu 
     850                855                860
Glu Met Gly Ile Gly Gly Val Leu Gly Leu Leu Trp Phe Gln Arg Arg 
 865                870                875                880
Leu Pro Lys Tyr Ser Cys Gln Phe Ile Glu Met Cys Leu Met Val Thr 
                 885                890                895
Ala Asp His Gly Pro Ala Val Ser Gly Ala His Asn Thr Ile Ile Cys 
             900                905                910
Ala Arg Ala Gly Lys Asp Leu Val Ser Ser Leu Thr Ser Gly Leu Leu 
         915                920                925
Thr Ile Gly Asp Arg Phe Gly Gly Ala Leu Asp Ala Ala Ala Lys Met 
     930                935                940
Phe Ser Lys Ala Phe Asp Ser Gly Ile Ile Pro Met Glu Phe Val Asn 
 945                950                955                960
Lys Met Lys Lys Glu Gly Lys Leu Ile Met Gly Ile Gly His Arg Val 
                 965                970                975
Lys Ser Ile Asn Asn Pro Asp Met Arg Val Gln Ile Leu Lys Asp Phe 
             980                985                990
Val Lys Gln His Phe Pro Ala Thr Pro Leu Leu Asp Tyr Ala Leu Glu 
         995                1000                1005
Val Glu Lys Ile Thr Thr Ser Lys Lys Pro Asn Leu Ile Leu Asn Val 
     1010                1015                1020
Asp Gly Phe Ile Gly Val Ala Phe Val Asp Met Leu Arg Asn Cys Gly 
 1025                1030                1035                1040
Ser Phe Thr Arg Glu Glu Ala Asp Glu Tyr Val Asp Ile Gly Ala Leu 
                 1045                1050                1055
Asn Gly Val Phe Val Leu Gly Arg Ser Met Gly Phe Ile Gly His Tyr 
             1060                1065                1070
Leu Asp Gln Lys Arg Leu Lys Gln Gly Leu Tyr Arg His Pro Trp Asp 
         1075                1080                1085
Asp Ile Ser Tyr Val Leu Pro Glu His Met Ser Met 
     1090                1095                1100



<210> 2625
<211> 4297
<212> DNA
<213> Homo sapiens
<308> X64330
<400> 2625

cccggattt  gcggggttc  tcgggcctg  ggaagaagc  ccgccacgg  cttcggcag  60
ggtagagca  gtctctctg  agccatgtc  gccaaggca  tttcagagc  gacgggcaa  120
gaactcctt  acaagttca  ctgtaccac  tcagccatc  agaatcggt  caagtatgc  180
cgggtcact  ctgacacag  ctgggcccg  ttgctgcag  accacccct  gctgctcag  240
cagaacttg  tagtcaagc  agaccagct  atcaaacgt  gtggaaaac  tggtctcgt  300
ggggtcgac  tcactctgg  tggggtcaa  tcctggctg  agccacggc  gggacagga  360
gccacagtt  gcaaggcca  aggcttcct  aagaacttt  tgatcgagc  cttcgcccc  420
cacagtcag  ctgaggagt  ctatgtctg  atctatgcc  cccgagaag  ggactacgt  480
ctgttccac  acgaggggg  tgtggacgt  ggtgatgtg  acgccaagg  ccagaagct  540
cttgttggc  tggatgaga  actgaatcc  gaggacatc  aaaaacacc  gttggtcca  600
gcccctgac  acaagaaag  aattctggc  agttttatc  ccggcctct  caatttcta  660
gaggacttg  acttcacct  cctcgagat  aatcccctt  tagtgacca  agatggagt  720
tatgtcctt  acttggcgg  caaggtgga  gccactgcc  actacatct  caaagtgaa  780
tggggtgac  tcgagttcc  tcccccctt  gggcgggtg  catatccag  ggaagccta  840
attgcagac  tcgatgcca  aagtggggc  agcctgaag  tgaccttgc  gaaccccaa  900
gggaggatc  ggaccatgg  ggccggggg  ggcgcctct  tcgtgtaca  cgataccat  960
tgtgatcta  ggggtgtca  cgagctggc  aactatggg  agtactcag  cgcccccag  1020
gagcagcag  cctatgact  tgccaagac  atcctctcc  tcatgaccc  agagaagca  1080
ccagatggc  agatcctca  cattggagg  agcatcgca  acttcacca  cgtggctgc  1140
acgttcaag  gcatcgtga  agcaattcg  gattaccag  gccccctga  ggagcacga  1200
gtcacaatc  ttgtccgaa  aggtggccc  aactatcag  agggcttac  ggtgatggg  1260
gaagtcggg  agaccactg  gatccccat  catgtcttt  gcacagaga  tcacatgac  1320
gccattgtg  gcatggcct  ggcaccggc  atccccaac  agccaccca  agcggccca  1380
actgcaaac  ttctcctca  cgcccagcg  gagacatcg  ctccagccc  cagcaggac  1440
gcatctttt  atgagtcca  ggtcgatga  gtcagggcc  atgaggtgg  gcctgcaaa  1500
aaggccaag  ctgccatgc  acaagattc  gtcccaagt  caagatccc  gcaaggaaa  1560
agcaccacc  tcttcagcc  ccacaccaa  gccattgtg  ggggcatgc  gacccgggc  1620
gtgcaaggc  tgctggact  tgactatgt  tgctcccga  acgagccct  agtggctgc  1680
atggtctat  ctttcactg  ggaccacaa  cagaagttt  actgggggc  caaagagat  1740
ctgatccct  tcttcaaga  catggctga  gccatgagg  agcacccgg  ggtagatgt  1800
ctcatcaac  ttgcctctc  ccgctctgc  tatgacagc  ccatggaga  catgaacta  1860
gcccagatc  ggaccatcg  catcatagc  gaaggcatc  ctgaggccc  cacgagaaa  1920
ctgatcaag  aggcggacc  gaagggagt  accatcatc  gacctgcca  tgttggagg  1980
atcaagcct  ggtgcttta  gattggcaa  acaggtggg  tgctggaca  catcctggc  2040
tccaaactg  acccccagg  agctgtggc  tatgtctca  gttccggag  catgtccaa  2100
gagctcaac  atatcatct  tcggaccac  gatggcgtc  atgagggcg  ggccattgg  2160
ggggacagg  acccgggct  cacattcat  gatcatgtg  tacgctatc  ggacactcc  2220
ggagtcaaa  tgattgtgg  tcttggaga  attgggggc  ctgaggaat  taagatttc  2280
cggggcatc  aggagggcc  cctcactaa  cccatcgtc  gctggtgca  cgggacgtg  2340
gccaccatg  tctcctctg  ggtccagtt  ggccatgct  gagcttgtg  caaccaggc  2400
tctgaaact  cagtagcca  gaaccaggc  ttgaaggaa  caggagtgt  tgtgccccg  2460
agctttgat  agcttggag  gatcatcca  tctgtatac  aagatctcg  ggccaatgg  2520
gtcattgta  ctgcccagg  ggtgccgcc  ccaaccgtg  ccatggact  ctcctgggc  2580
agggagctt  gtttgatcc  caaacctgc  tcgttcatg  ccagcatct  cgatgagcg  2640
ggacaggag  tcatctacg  gggcatgcc  atcactgag  tcttcaagg  agagatggg  2700
attggcggg  ccctcggcc  cctctggtt  cagaaaagg  tgcctaagt  ctcttgcca  2760
ttcattgag  tgtgtctga  ggtgacagc  gatcacggg  cagccgtct  tggagccca  2820
aacaccatc  tttgtgcgc  caccgcggt  gagctggtc  ccagcctca  ctcggggct  2880
ctcaccatc  gggatcggt  tgggggtgc  ttggatgca  cagccaaga  gttcagtaa  2940
gcctttgac  gtggcatta  ccccatgga  tttgtgaac  agatgaaga  ggaagggaa  3000
ctgatcatg  gcattggtc  ccgagtgaa  tcgataaac  acccagaca  gcgagtgca  3060
atcctcaaa  attacgtca  gcagcactt  cctgccact  ctctgctcg  ttatgcact  3120
gaagtagag  agattacca  ctcgaagaa  ccaaatctt  tcctgaatg  agatggtct  3180
atcggagtc  catttgtag  catgcttag  aactgtggg  cctttactc  ggaggaagc  3240
gatgaatat  ttgacattg  agccctcaa  ggcatcttt  tgctgggaa  gagtatggg  3300
ttcattgga  actatcttg  tcagaagag  ctgaagcag  ggctgtatc  tcatccgtg  3360
gatgatatt  catatgttc  tccggaaca  atgagcatg  aacagagcc  ggaacccta  3420
tgcagtaaa  tgaagacaa  aactcttcc  ccaagaaaa  gtgtcagac  gctggcagt  3480
gagcctgct  tatttagca  gggcctgga  tgtaaacag  cactggggt  caggcaccg  3540
agaccaaca  ccacaggct  acacccctt  agtccacac  aagaagctt  atatttttt  3600
tataagcat  gaaataaaa  ccaagccaa  atttgtgac  ttgctctgc  acctgctgt  3660
tttattata  ggaagcatc  aagtactgt  aggatgggg  cttcctcat  gtagggcgt  3720
aggatgttg  tttcttttt  cattagtta  acatttttt  ctcctttgg  ggaagggaa  3780
gaaacattt  tggcctcaa  atactatac  tttaaagca  cccaatgtc  ctctttttt  3840
tttttttta  ttcccttgc  tcttcctta  ataacatga  gaacattgt  ttaatctga  3900
ttttaaaga  tttttgtat  ttacgtgtt  agggcttgt  tggtatccc  ctgaaatgt  3960
ctgtgttgc  gaccagagt  tgtttatgt  agggggagg  ggccattgc  tccttagcc  4020
ttgtcacaa  atatgtgga  tagtaactt  atatgtaaa  ttgtaacat  catacattt  4080
aaatggaaa  gcagaaagc  gtgaaatgt  ttgtgtctt  tgttctctg  atttatgca  4140
ctgatttgt  tgtctgtaa  tgaagtgtg  gtccaagga  tcctaacta  tttgcatct  4200
taatccaca  agattctgg  cagctgcca  ctcagtctc  tctctgtat  atcatagtc  4260
ggtttaaat  aactatata  taacaggaa  tcctgca  4297



<210> 2626
<211> 1101
<212> PRT
<213> Homo sapiens
<308> P53396
<400> 2626

Met Ser Ala Lys Ala Ile Ser Glu Gln Thr Gly Lys Glu Leu Leu Tyr 
  1               5                  10                  15
Lys Phe Ile Cys Thr Thr Ser Ala Ile Gln Asn Arg Phe Lys Tyr Ala 
             20                  25                  30
Arg Val Thr Pro Asp Thr Asp Trp Ala Arg Leu Leu Gln Asp His Pro 
         35                  40                  45
Trp Leu Leu Ser Gln Asn Leu Val Val Lys Pro Asp Gln Leu Ile Lys 
     50                  55                  60
Arg Arg Gly Lys Leu Gly Leu Val Gly Val Asn Leu Thr Leu Asp Gly 
 65                  70                  75                  80
Val Lys Ser Trp Leu Lys Pro Arg Leu Gly Gln Glu Ala Thr Val Gly 
                 85                  90                  95
Lys Ala Thr Gly Phe Leu Lys Asn Phe Leu Ile Glu Pro Phe Val Pro 
             100                105                110
His Ser Gln Ala Glu Glu Phe Tyr Val Cys Ile Tyr Ala Thr Arg Glu 
         115                120                125
Gly Asp Tyr Val Leu Phe His His Glu Gly Gly Val Asp Val Gly Asp 
     130                135                140
Val Asp Ala Lys Ala Gln Lys Leu Leu Val Gly Val Asp Glu Lys Leu 
 145                150                155                160
Asn Pro Glu Asp Ile Lys Lys His Leu Leu Val His Ala Pro Asp Asp 
                 165                170                175
Lys Lys Glu Ile Leu Ala Ser Phe Ile Ser Gly Leu Phe Asn Phe Tyr 
             180                185                190
Glu Asp Leu Tyr Phe Thr Tyr Leu Glu Ile Asn Pro Leu Val Val Thr 
         195                200                205
Lys Asp Gly Val Tyr Val Leu Asp Leu Ala Ala Lys Val Asp Ala Thr 
     210                215                220
Ala Asp Tyr Ile Cys Lys Val Lys Trp Gly Asp Ile Glu Phe Pro Pro 
 225                230                235                240
Pro Phe Gly Arg Glu Ala Tyr Pro Glu Glu Ala Tyr Ile Ala Asp Leu 
                 245                250                255
Asp Ala Lys Ser Gly Ala Ser Leu Lys Leu Thr Leu Leu Asn Pro Lys 
             260                265                270
Gly Arg Ile Trp Thr Met Val Ala Gly Gly Gly Ala Ser Val Val Tyr 
         275                280                285
Ser Asp Thr Ile Cys Asp Leu Gly Gly Val Asn Glu Leu Ala Asn Tyr 
     290                295                300
Gly Glu Tyr Ser Gly Ala Pro Ser Glu Gln Gln Thr Tyr Asp Tyr Ala 
 305                310                315                320
Lys Thr Ile Leu Ser Leu Met Thr Arg Glu Lys His Pro Asp Gly Lys 
                 325                330                335
Ile Leu Ile Ile Gly Gly Ser Ile Ala Asn Phe Thr Asn Val Ala Ala 
             340                345                350
Thr Phe Lys Gly Ile Val Arg Ala Ile Arg Asp Tyr Gln Gly Pro Leu 
         355                360                365
Lys Glu His Glu Val Thr Ile Phe Val Arg Arg Gly Gly Pro Asn Tyr 
     370                375                380
Gln Glu Gly Leu Arg Val Met Gly Glu Val Gly Lys Thr Thr Gly Ile 
 385                390                395                400
Pro Ile His Val Phe Gly Thr Glu Thr His Met Thr Ala Ile Val Gly 
                 405                410                415
Met Ala Leu Gly His Arg Pro Ile Pro Asn Gln Pro Pro Thr Ala Ala 
             420                425                430
His Thr Ala Asn Phe Leu Leu Asn Ala Ser Gly Ser Thr Ser Thr Pro 
         435                440                445
Ala Pro Ser Arg Thr Ala Ser Phe Ser Glu Ser Arg Ala Asp Glu Val 
     450                455                460
Ala Pro Ala Lys Lys Ala Lys Pro Ala Met Pro Gln Asp Ser Val Pro 
 465                470                475                480
Ser Pro Arg Ser Leu Gln Gly Lys Ser Thr Thr Leu Phe Ser Arg His 
                 485                490                495
Thr Lys Ala Ile Val Trp Gly Met Gln Thr Arg Ala Val Gln Gly Met 
             500                505                510
Leu Asp Phe Asp Tyr Val Cys Ser Arg Asp Glu Pro Ser Val Ala Ala 
         515                520                525
Met Val Tyr Pro Phe Thr Gly Asp His Lys Gln Lys Phe Tyr Trp Gly 
     530                535                540
His Lys Glu Ile Leu Ile Pro Val Phe Lys Asn Met Ala Asp Ala Met 
 545                550                555                560
Arg Lys His Pro Glu Val Asp Val Leu Ile Asn Phe Ala Ser Leu Arg 
                 565                570                575
Ser Ala Tyr Asp Ser Thr Met Glu Thr Met Asn Tyr Ala Gln Ile Arg 
             580                585                590
Thr Ile Ala Ile Ile Ala Glu Gly Ile Pro Glu Ala Leu Thr Arg Lys 
         595                600                605
Leu Ile Lys Lys Ala Asp Gln Lys Gly Val Thr Ile Ile Gly Pro Ala 
     610                615                620
Thr Val Gly Gly Ile Lys Pro Gly Cys Phe Lys Ile Gly Asn Thr Gly 
 625                630                635                640
Gly Met Leu Asp Asn Ile Leu Ala Ser Lys Leu Tyr Arg Pro Gly Ser 
                 645                650                655
Val Ala Tyr Val Ser Arg Ser Gly Gly Met Ser Asn Glu Leu Asn Asn 
             660                665                670
Ile Ile Ser Arg Thr Thr Asp Gly Val Tyr Glu Gly Val Ala Ile Gly 
         675                680                685
Gly Asp Arg Tyr Pro Gly Ser Thr Phe Met Asp His Val Leu Arg Tyr 
     690                695                700
Gln Asp Thr Pro Gly Val Lys Met Ile Val Val Leu Gly Glu Ile Gly 
 705                710                715                720
Gly Thr Glu Glu Tyr Lys Ile Cys Arg Gly Ile Lys Glu Gly Arg Leu 
                 725                730                735
Thr Lys Pro Ile Val Cys Trp Cys Ile Gly Thr Cys Ala Thr Met Phe 
             740                745                750
Ser Ser Glu Val Gln Phe Gly His Ala Gly Ala Cys Ala Asn Gln Ala 
         755                760                765
Ser Glu Thr Ala Val Ala Lys Asn Gln Ala Leu Lys Glu Ala Gly Val 
     770                775                780
Phe Val Pro Arg Ser Phe Asp Glu Leu Gly Glu Ile Ile Gln Ser Val 
 785                790                795                800
Tyr Glu Asp Leu Val Ala Asn Gly Val Ile Val Pro Ala Gln Glu Val 
                 805                810                815
Pro Pro Pro Thr Val Pro Met Asp Tyr Ser Trp Ala Arg Glu Leu Gly 
             820                825                830
Leu Ile Arg Lys Pro Ala Ser Phe Met Thr Ser Ile Cys Asp Glu Arg 
         835                840                845
Gly Gln Glu Leu Ile Tyr Ala Gly Met Pro Ile Thr Glu Val Phe Lys 
     850                855                860
Glu Glu Met Gly Ile Gly Gly Val Leu Gly Leu Leu Trp Phe Gln Lys 
 865                870                875                880
Arg Leu Pro Lys Tyr Ser Cys Gln Phe Ile Glu Met Cys Leu Met Val 
                 885                890                895
Thr Ala Asp His Gly Pro Ala Val Ser Gly Ala His Asn Thr Ile Ile 
             900                905                910
Cys Ala Arg Ala Gly Lys Asp Leu Val Ser Ser Leu Thr Ser Gly Leu 
         915                920                925
Leu Thr Ile Gly Asp Arg Phe Gly Gly Ala Leu Asp Ala Ala Ala Lys 
     930                935                940
Met Phe Ser Lys Ala Phe Asp Ser Gly Ile Ile Pro Met Glu Phe Val 
 945                950                955                960
Asn Lys Met Lys Lys Glu Gly Lys Leu Ile Met Gly Ile Gly His Arg 
                 965                970                975
Val Lys Ser Ile Asn Asn Pro Asp Met Arg Val Gln Ile Leu Lys Asp 
             980                985                990
Tyr Val Arg Gln His Phe Pro Ala Thr Pro Leu Leu Asp Tyr Ala Leu 
         995                1000                1005
Glu Val Glu Lys Ile Thr Thr Ser Lys Lys Pro Asn Leu Ile Leu Asn 
     1010                1015                1020
Val Asp Gly Leu Ile Gly Val Ala Phe Val Asp Met Leu Arg Asn Cys 
 1025                1030                1035                1040
Gly Ser Phe Thr Arg Glu Glu Ala Asp Glu Tyr Ile Asp Ile Gly Ala 
                 1045                1050                1055
Leu Asn Gly Ile Phe Val Leu Gly Arg Ser Met Gly Phe Ile Gly His 
             1060                1065                1070
Tyr Leu Asp Gln Lys Arg Leu Lys Gln Gly Leu Tyr Arg His Pro Trp 
         1075                1080                1085
Asp Asp Ile Ser Tyr Val Leu Pro Glu His Met Ser Met 
     1090                1095                1100



<210> 2627
<211> 1269
<212> DNA
<213> Rattus norvegicus
<308> J05405
<400> 2627

gataagtct  gctatttct  tccaggcac  gagtgttgg  gtgtgccat  tcccccttt  60
ggaccacct  gggttgccc  cttagcaaa  ttggcctta  caaggagca  tcatcttgg  120
ttatataat  tgaatgagc  aaggaccga  gtgagggca  cacaaacaa  tcagcaaca  180
tgtcttcag  ggtggagac  tcggagggc  tcgatgagt  agagaacaa  tctacggca  240
cagaaaagg  aaaccatac  aaaatggca  acctttctg  gctcctgaa  gaagggacc  300
aggaagcac  tgaccgggc  gaaaatacc  agtttgtca  agacttctt  aaaggaaac  360
ttaagaagg  gctatttaa  ctggccacc  ctgcacttt  cttcacata  tcagccctt  420
aggaggaaa  ggatcgcaa  aaggaccac  cagccttcg  ccccttata  ttccccacg  480
aactacacc  gaaggaagc  ctgatcaag  acatggagt  tttctttgg  gaaaactgg  540
aggagcagg  gaagtgctc  gaggctgcc  agaagtatg  ggatcggat  cactacgta  600
gacagaatg  gccagagct  ctggtggcc  atgcttaca  tcgttacat  ggggacctt  660
cgggaggcc  ggtgctgaa  aaggtggct  agcgggcac  aaaactccc  agcactggg  720
aagggaccc  gttctacct  ttcgagcat  tggacaatg  ccagcaatt  aagcagttc  780
accgcgcca  gatgaatgc  ttggacctg  gtatgaaga  caaagagag  attgtggag  840
aggccaaca  agcctttga  tataatatg  agatattca  tgaactgga  caggctggc  900
ccatgctaa  aaaagaaac  ctggaggat  ggctcccag  acatgatgg  aaaggagat  960
tacgtaaat  cccctttta  gctgctcag  cagacaaag  taccctggg  ggcagcaac  1020
gccccttcc  gacagccat  gctgtgctg  ggaagccta  cctgcagct  attctggct  1080
ccagtgtgg  cttggtagc  ggactcttg  cctggtact  catgtgaag  acctgtcat  1140
ttgtttgca  cctatccca  gtgacctct  ccatcccca  ctccacctc  gcccaaaac  1200
accacctca  gtgactttt  taatgctgg  tttgagaaa  caagcaacc  ataaaagcc  1260
gacactagc  1269



<210> 2628
<211> 315
<212> PRT
<213> Rattus norvegicus
<308> P23711
<400> 2628

Met Ser Ser Glu Val Glu Thr Ser Glu Gly Val Asp Glu Ser Glu Asn 
  1               5                  10                  15
Asn Ser Thr Ala Pro Glu Lys Glu Asn His Thr Lys Met Ala Asp Leu 
             20                  25                  30
Ser Glu Leu Leu Lys Glu Gly Thr Lys Glu Ala His Asp Arg Ala Glu 
         35                  40                  45
Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys Glu 
     50                  55                  60
Leu Phe Lys Leu Ala Thr Thr Ala Leu Tyr Phe Thr Tyr Ser Ala Leu 
 65                  70                  75                  80
Glu Glu Glu Met Asp Arg Asn Lys Asp His Pro Ala Phe Ala Pro Leu 
                 85                  90                  95
Tyr Phe Pro Thr Glu Leu His Arg Lys Glu Ala Leu Ile Lys Asp Met 
             100                105                110
Glu Tyr Phe Phe Gly Glu Asn Trp Glu Glu Gln Val Lys Cys Ser Glu 
         115                120                125
Ala Ala Gln Lys Tyr Val Asp Arg Ile His Tyr Val Gly Gln Asn Glu 
     130                135                140
Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Met Gly Asp Leu 
 145                150                155                160
Ser Gly Gly Gln Val Leu Lys Lys Val Ala Gln Arg Ala Leu Lys Leu 
                 165                170                175
Pro Ser Thr Gly Glu Gly Thr Gln Phe Tyr Leu Phe Glu His Val Asp 
             180                185                190
Asn Ala Gln Gln Phe Lys Gln Phe Tyr Arg Ala Arg Met Asn Ala Leu 
         195                200                205
Asp Leu Ser Met Lys Thr Lys Glu Arg Ile Val Glu Glu Ala Asn Lys 
     210                215                220
Ala Phe Glu Tyr Asn Met Gln Ile Phe Ser Glu Leu Asp Gln Ala Gly 
 225                230                235                240
Ser Met Leu Thr Lys Glu Thr Leu Glu Asp Gly Leu Pro Val His Asp 
                 245                250                255
Gly Lys Gly Asp Val Arg Lys Cys Pro Phe Tyr Ala Ala Gln Pro Asp 
             260                265                270
Lys Gly Thr Leu Gly Gly Ser Asn Cys Pro Phe Arg Thr Ala Met Ala 
         275                280                285
Val Leu Arg Lys Pro Ser Leu Gln Leu Ile Leu Ala Ala Ser Val Ala 
     290                295                300
Leu Val Ala Gly Leu Leu Ala Trp Tyr Tyr Met 
 305                310                315



<210> 2629
<211> 977
<212> DNA
<213> Homo sapiens
<308> D21243
<400> 2629

atgtcagcg  aagtggaaa  ctcagaggg  gtagacgag  cagaaaaaa  gaactctgg  60
gccctagaa  aggagaacc  aatgagaat  gctgacctc  cggagctcc  gaaggaagg  120
accaaggaa  cacacgacc  ggcagaaaa  acccagttt  tcaaggact  cttgaaagg  180
aacattaag  aggagctgt  taagctggc  accacggca  tttacttca  atactcagc  240
ctcgaggag  aaatggagc  caacaagga  catccagcc  ttgcccctt  gtacttccc  300
atggagctg  accggaagg  ggcgctgac  aaggacatg  agtatttct  tggtgaaaa  360
tgggaggag  aggtgcagt  ccccaaggc  gcccagaag  acgtggagc  gatccacta  420
atagggcag  acgagccgg  gctactggt  gcccatgca  acacccgct  catggggga  480
ctctcgggg  gccaggtgc  gaagaaggt  gcccagcga  cactgaaac  ccccagcac  540
ggggaaggg  cccagttct  cctgtttga  aatgtggac  atgcccagc  gttcaagca  600
ctctaccgg  ccaggatga  cgccctgga  ctgaacatg  agaccaaag  gaggatcgt  660
gaggaggcc  acaaggctt  tgagtataa  atgcagata  tcaatgaac  ggaccaggc  720
ggctccaca  tggccagag  gaccttgga  gatgggttc  ctgtacacg  tgggaaagg  780
gacatgcgt  aatgccctt  ctacgctgc  gaacaagac  aaggtgccc  ggagggcag  840
agctgtccc  tccgaacag  tatggctgt  ctgaggaag  ccagcctcc  gttcatcct  900
gccgctggt  tggccctag  tgctggact  ttggcctgg  actacatgt  aagcaccca  960
catgccaca  cggtacc  977



<210> 2630
<211> 316
<212> PRT
<213> Homo sapiens
<308> P30519
<400> 2630

Met Ser Ala Glu Val Glu Thr Ser Glu Gly Val Asp Glu Ser Glu Lys 
  1               5                  10                  15
Lys Asn Ser Gly Ala Leu Glu Lys Glu Asn Gln Met Arg Met Ala Asp 
             20                  25                  30
Leu Ser Glu Leu Leu Lys Glu Gly Thr Lys Glu Ala His Asp Arg Ala 
         35                  40                  45
Glu Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys 
     50                  55                  60
Glu Leu Phe Lys Leu Ala Thr Thr Ala Leu Tyr Phe Thr Tyr Ser Ala 
 65                  70                  75                  80
Leu Glu Glu Glu Met Glu Arg Asn Lys Asp His Pro Ala Phe Ala Pro 
                 85                  90                  95
Leu Tyr Phe Pro Met Glu Leu His Arg Lys Glu Ala Leu Thr Lys Asp 
             100                105                110
Met Glu Tyr Phe Phe Gly Glu Asn Trp Glu Glu Gln Val Gln Cys Pro 
         115                120                125
Lys Ala Ala Gln Lys Tyr Val Glu Arg Ile His Tyr Ile Gly Gln Asn 
     130                135                140
Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Met Gly Asp 
 145                150                155                160
Leu Ser Gly Gly Gln Val Leu Lys Lys Val Ala Gln Arg Ala Leu Lys 
                 165                170                175
Leu Pro Ser Thr Gly Glu Gly Thr Gln Phe Tyr Leu Phe Glu Asn Val 
             180                185                190
Asp Asn Ala Gln Gln Phe Lys Gln Leu Tyr Arg Ala Arg Met Asn Ala 
         195                200                205
Leu Asp Leu Asn Met Lys Thr Lys Glu Arg Ile Val Glu Glu Ala Asn 
     210                215                220
Lys Ala Phe Glu Tyr Asn Met Gln Ile Phe Asn Glu Leu Asp Gln Ala 
 225                230                235                240
Gly Ser Thr Leu Ala Arg Glu Thr Leu Glu Asp Gly Phe Pro Val His 
                 245                250                255
Asp Gly Lys Gly Asp Met Arg Lys Cys Pro Phe Tyr Ala Ala Glu Gln 
             260                265                270
Asp Lys Gly Ala Leu Glu Gly Ser Ser Cys Pro Phe Arg Thr Ala Met 
         275                280                285
Ala Val Leu Arg Lys Pro Ser Leu Gln Phe Ile Leu Ala Ala Gly Val 
     290                295                300
Ala Leu Ala Ala Gly Leu Leu Ala Trp Tyr Tyr Met 
 305                310                315



<210> 2631
<211> 1269
<212> DNA
<213> Rattus norvegicus
<308> J05405
<400> 2631

gataagtct  gctatttct  tccaggcac  gagtgttgg  gtgtgccat  tcccccttt  60
ggaccacct  gggttgccc  cttagcaaa  ttggcctta  caaggagca  tcatcttgg  120
ttatataat  tgaatgagc  aaggaccga  gtgagggca  cacaaacaa  tcagcaaca  180
tgtcttcag  ggtggagac  tcggagggc  tcgatgagt  agagaacaa  tctacggca  240
cagaaaagg  aaaccatac  aaaatggca  acctttctg  gctcctgaa  gaagggacc  300
aggaagcac  tgaccgggc  gaaaatacc  agtttgtca  agacttctt  aaaggaaac  360
ttaagaagg  gctatttaa  ctggccacc  ctgcacttt  cttcacata  tcagccctt  420
aggaggaaa  ggatcgcaa  aaggaccac  cagccttcg  ccccttata  ttccccacg  480
aactacacc  gaaggaagc  ctgatcaag  acatggagt  tttctttgg  gaaaactgg  540
aggagcagg  gaagtgctc  gaggctgcc  agaagtatg  ggatcggat  cactacgta  600
gacagaatg  gccagagct  ctggtggcc  atgcttaca  tcgttacat  ggggacctt  660
cgggaggcc  ggtgctgaa  aaggtggct  agcgggcac  aaaactccc  agcactggg  720
aagggaccc  gttctacct  ttcgagcat  tggacaatg  ccagcaatt  aagcagttc  780
accgcgcca  gatgaatgc  ttggacctg  gtatgaaga  caaagagag  attgtggag  840
aggccaaca  agcctttga  tataatatg  agatattca  tgaactgga  caggctggc  900
ccatgctaa  aaaagaaac  ctggaggat  ggctcccag  acatgatgg  aaaggagat  960
tacgtaaat  cccctttta  gctgctcag  cagacaaag  taccctggg  ggcagcaac  1020
gccccttcc  gacagccat  gctgtgctg  ggaagccta  cctgcagct  attctggct  1080
ccagtgtgg  cttggtagc  ggactcttg  cctggtact  catgtgaag  acctgtcat  1140
ttgtttgca  cctatccca  gtgacctct  ccatcccca  ctccacctc  gcccaaaac  1200
accacctca  gtgactttt  taatgctgg  tttgagaaa  caagcaacc  ataaaagcc  1260
gacactagc  1269



<210> 2632
<211> 315
<212> PRT
<213> Rattus norvegicus
<308> P23711
<400> 2632

Met Ser Ser Glu Val Glu Thr Ser Glu Gly Val Asp Glu Ser Glu Asn 
  1               5                  10                  15
Asn Ser Thr Ala Pro Glu Lys Glu Asn His Thr Lys Met Ala Asp Leu 
             20                  25                  30
Ser Glu Leu Leu Lys Glu Gly Thr Lys Glu Ala His Asp Arg Ala Glu 
         35                  40                  45
Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys Glu 
     50                  55                  60
Leu Phe Lys Leu Ala Thr Thr Ala Leu Tyr Phe Thr Tyr Ser Ala Leu 
 65                  70                  75                  80
Glu Glu Glu Met Asp Arg Asn Lys Asp His Pro Ala Phe Ala Pro Leu 
                 85                  90                  95
Tyr Phe Pro Thr Glu Leu His Arg Lys Glu Ala Leu Ile Lys Asp Met 
             100                105                110
Glu Tyr Phe Phe Gly Glu Asn Trp Glu Glu Gln Val Lys Cys Ser Glu 
         115                120                125
Ala Ala Gln Lys Tyr Val Asp Arg Ile His Tyr Val Gly Gln Asn Glu 
     130                135                140
Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Met Gly Asp Leu 
 145                150                155                160
Ser Gly Gly Gln Val Leu Lys Lys Val Ala Gln Arg Ala Leu Lys Leu 
                 165                170                175
Pro Ser Thr Gly Glu Gly Thr Gln Phe Tyr Leu Phe Glu His Val Asp 
             180                185                190
Asn Ala Gln Gln Phe Lys Gln Phe Tyr Arg Ala Arg Met Asn Ala Leu 
         195                200                205
Asp Leu Ser Met Lys Thr Lys Glu Arg Ile Val Glu Glu Ala Asn Lys 
     210                215                220
Ala Phe Glu Tyr Asn Met Gln Ile Phe Ser Glu Leu Asp Gln Ala Gly 
 225                230                235                240
Ser Met Leu Thr Lys Glu Thr Leu Glu Asp Gly Leu Pro Val His Asp 
                 245                250                255
Gly Lys Gly Asp Val Arg Lys Cys Pro Phe Tyr Ala Ala Gln Pro Asp 
             260                265                270
Lys Gly Thr Leu Gly Gly Ser Asn Cys Pro Phe Arg Thr Ala Met Ala 
         275                280                285
Val Leu Arg Lys Pro Ser Leu Gln Leu Ile Leu Ala Ala Ser Val Ala 
     290                295                300
Leu Val Ala Gly Leu Leu Ala Trp Tyr Tyr Met 
 305                310                315



<210> 2633
<211> 977
<212> DNA
<213> Homo sapiens
<308> D21243
<400> 2633

atgtcagcg  aagtggaaa  ctcagaggg  gtagacgag  cagaaaaaa  gaactctgg  60
gccctagaa  aggagaacc  aatgagaat  gctgacctc  cggagctcc  gaaggaagg  120
accaaggaa  cacacgacc  ggcagaaaa  acccagttt  tcaaggact  cttgaaagg  180
aacattaag  aggagctgt  taagctggc  accacggca  tttacttca  atactcagc  240
ctcgaggag  aaatggagc  caacaagga  catccagcc  ttgcccctt  gtacttccc  300
atggagctg  accggaagg  ggcgctgac  aaggacatg  agtatttct  tggtgaaaa  360
tgggaggag  aggtgcagt  ccccaaggc  gcccagaag  acgtggagc  gatccacta  420
atagggcag  acgagccgg  gctactggt  gcccatgca  acacccgct  catggggga  480
ctctcgggg  gccaggtgc  gaagaaggt  gcccagcga  cactgaaac  ccccagcac  540
ggggaaggg  cccagttct  cctgtttga  aatgtggac  atgcccagc  gttcaagca  600
ctctaccgg  ccaggatga  cgccctgga  ctgaacatg  agaccaaag  gaggatcgt  660
gaggaggcc  acaaggctt  tgagtataa  atgcagata  tcaatgaac  ggaccaggc  720
ggctccaca  tggccagag  gaccttgga  gatgggttc  ctgtacacg  tgggaaagg  780
gacatgcgt  aatgccctt  ctacgctgc  gaacaagac  aaggtgccc  ggagggcag  840
agctgtccc  tccgaacag  tatggctgt  ctgaggaag  ccagcctcc  gttcatcct  900
gccgctggt  tggccctag  tgctggact  ttggcctgg  actacatgt  aagcaccca  960
catgccaca  cggtacc  977



<210> 2634
<211> 316
<212> PRT
<213> Homo sapiens
<308> P30519
<400> 2634

Met Ser Ala Glu Val Glu Thr Ser Glu Gly Val Asp Glu Ser Glu Lys 
  1               5                  10                  15
Lys Asn Ser Gly Ala Leu Glu Lys Glu Asn Gln Met Arg Met Ala Asp 
             20                  25                  30
Leu Ser Glu Leu Leu Lys Glu Gly Thr Lys Glu Ala His Asp Arg Ala 
         35                  40                  45
Glu Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys 
     50                  55                  60
Glu Leu Phe Lys Leu Ala Thr Thr Ala Leu Tyr Phe Thr Tyr Ser Ala 
 65                  70                  75                  80
Leu Glu Glu Glu Met Glu Arg Asn Lys Asp His Pro Ala Phe Ala Pro 
                 85                  90                  95
Leu Tyr Phe Pro Met Glu Leu His Arg Lys Glu Ala Leu Thr Lys Asp 
             100                105                110
Met Glu Tyr Phe Phe Gly Glu Asn Trp Glu Glu Gln Val Gln Cys Pro 
         115                120                125
Lys Ala Ala Gln Lys Tyr Val Glu Arg Ile His Tyr Ile Gly Gln Asn 
     130                135                140
Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Met Gly Asp 
 145                150                155                160
Leu Ser Gly Gly Gln Val Leu Lys Lys Val Ala Gln Arg Ala Leu Lys 
                 165                170                175
Leu Pro Ser Thr Gly Glu Gly Thr Gln Phe Tyr Leu Phe Glu Asn Val 
             180                185                190
Asp Asn Ala Gln Gln Phe Lys Gln Leu Tyr Arg Ala Arg Met Asn Ala 
         195                200                205
Leu Asp Leu Asn Met Lys Thr Lys Glu Arg Ile Val Glu Glu Ala Asn 
     210                215                220
Lys Ala Phe Glu Tyr Asn Met Gln Ile Phe Asn Glu Leu Asp Gln Ala 
 225                230                235                240
Gly Ser Thr Leu Ala Arg Glu Thr Leu Glu Asp Gly Phe Pro Val His 
                 245                250                255
Asp Gly Lys Gly Asp Met Arg Lys Cys Pro Phe Tyr Ala Ala Glu Gln 
             260                265                270
Asp Lys Gly Ala Leu Glu Gly Ser Ser Cys Pro Phe Arg Thr Ala Met 
         275                280                285
Ala Val Leu Arg Lys Pro Ser Leu Gln Phe Ile Leu Ala Ala Gly Val 
     290                295                300
Ala Leu Ala Ala Gly Leu Leu Ala Trp Tyr Tyr Met 
 305                310                315



<210> 2635
<211> 2296
<212> DNA
<213> Rattus norvegicus
<308> J05470
<400> 2635

cctgcttgc  caggaactc  ctcagccgc  gcgttctct  gccgccgtt  ctgcccggg  60
cgatgatgc  gcgcctgct  tttcgtgcc  ggccccgct  cccctcgct  gtcctggga  120
cccctagta  gcccttaag  gctgtctcg  ggccggacg  ttatctgca  cacagcatc  180
tgcccacca  gcactacca  gacagcctg  ccaggctgc  tatccctaa  cttgaagac  240
ccatgaaga  atacctcaa  gcacagaag  ctctcttgg  tgacagcca  ttcaggaga  300
cagaagcgt  gtgtaagaa  tttgagact  gcgttggga  ggagctgca  gcccacctg  360
ttgctcagg  taagcagaa  aagcacacc  gctacatct  aggcccctg  ttcgatatg  420
atttaactg  tcgagactc  atcgtttta  actttaatc  atttatggc  ttcaatccg  480
acccaaagt  tgagtataa  gaccagctt  ccagggcaa  caacttgac  gtttctgca  540
tccggtttc  gaagacact  caggctggc  ttttagaac  agaagtgtt  cacttgaac  600
cttccaaaa  tgacacaga  gccttcaaa  gactcattc  ctttgttcc  ccctctctg  660
cctggtatg  agcctacct  gtcaacgca  atcccctgg  tatgtccca  tatttccgg  720
ttttcaatt  aactcgtat  cccagaccc  atcgtgatg  actctttac  gacaccaag  780
ctagacacc  cctggtcct  agaaaagga  atttctatg  ctttgatgt  ctcgatcaa  840
atgggaaca  tgtgaatcc  ttagagatt  aggcacatc  aaagtacat  ctctcagac  900
gcagccctg  gcccgagtt  cctgtggca  atctgacca  tgagaaccg  gatgtctgg  960
cagagctca  acagaagtt  atttttgat  gcaatgagg  aaccctgaa  aaagtggac  1020
ctgctgtct  ctgcctctg  ctagatgac  tcccgatga  ggatcttat  cacttgtca  1080
acaccatgc  gcacggcga  ggcacaaac  gctggtttg  taagtcctt  aacctcatt  1140
tagccgagg  cggcactgc  gcagtccac  tcgagcact  gtgggggga  ggggtggca  1200
tgcttaggt  tttcaatga  gtgttcaga  acagcactc  gacccctgc  atcactccc  1260
agagccagc  tgccgccac  aactcctct  cgtctgtgg  gacgctcag  ttcaacctc  1320
gcggtgctc  caaggctgg  atcactgct  ccaaggaga  gttcgacac  acggtgaaa  1380
ccctcagca  tgactccat  cagttccag  gaggtggca  ggagttcct  aagaagaag  1440
agctgagcc  cgatgcggt  gcccagctg  ccttccaga  ggccttcct  agacagtat  1500
gccagacgg  ggctaccta  gagtcctgc  gcactgcag  cttcaagca  ggccgcaca  1560
agactatcc  cccagcctc  atctttact  agagatgct  cgaggcgtt  gtcagggac  1620
cctccaagc  cagtgtggg  gagcttcag  acatgatgg  tgagtgttc  aaataccat  1680
gccagctga  caaagaagc  gcgatgggc  agggctttg  ccgacactt  tatgctctg  1740
gctatctgg  aacggccag  ggactcaac  tacctgagc  ctatctgga  cctgcatac  1800
agcagatga  ccacaacat  ctgtccacc  gcactctga  cagcccagc  gtgagcctt  1860
ggggctttg  ccctgtggt  cctgatggc  ttggcattg  atatgctgt  cacgatgac  1920
ggataggct  caatgtctc  tcctactca  gacgcaatg  ccgagagtt  ctccactgt  1980
tccagaagt  cttggaaga  attttcgat  ctctagaag  caaagccat  aaaacttag  2040
ttcctagtc  ctgaaaagc  tccattctt  ctcatgaac  tggatgttc  tgtagctgg  2100
aggtgccat  ttgtgccca  caaaactaa  cccaaggtg  ttccacagc  agtgctgca  2160
gctgagctg  aagagccca  ctgaaggta  tgagaggtc  cagctgtaa  gccctcttt  2220
ttcaggaga  agggtttgg  aaactaact  agctgtatt  attgtttaa  tagaaataa  2280
acctggtgt  gcttag  2296



<210> 2636
<211> 658
<212> PRT
<213> Rattus norvegicus
<308> P18886
<400> 2636

Met Met Pro Arg Leu Leu Phe Arg Ala Trp Pro Arg Cys Pro Ser Leu 
  1               5                  10                  15
Val Leu Gly Ala Pro Ser Arg Pro Leu Ser Ala Val Ser Gly Pro Asp 
             20                  25                  30
Asp Tyr Leu Gln His Ser Ile Val Pro Thr Met His Tyr Gln Asp Ser 
         35                  40                  45
Leu Pro Arg Leu Pro Ile Pro Lys Leu Glu Asp Thr Met Lys Arg Tyr 
     50                  55                  60
Leu Asn Ala Gln Lys Pro Leu Leu Asp Asp Ser Gln Phe Arg Arg Thr 
 65                  70                  75                  80
Glu Ala Leu Cys Lys Asn Phe Glu Thr Gly Val Gly Lys Glu Leu His 
                 85                  90                  95
Ala His Leu Leu Ala Gln Asp Lys Gln Asn Lys His Thr Ser Tyr Ile 
             100                105                110
Ser Gly Pro Trp Phe Asp Met Tyr Leu Thr Ala Arg Asp Ser Ile Val 
         115                120                125
Leu Asn Phe Asn Pro Phe Met Ala Phe Asn Pro Asp Pro Lys Ser Glu 
     130                135                140
Tyr Asn Asp Gln Leu Thr Arg Ala Thr Asn Leu Thr Val Ser Ala Val 
 145                150                155                160
Arg Phe Leu Lys Thr Leu Gln Ala Gly Leu Leu Glu Pro Glu Val Phe 
                 165                170                175
His Leu Asn Pro Ser Lys Ser Asp Thr Asp Ala Phe Lys Arg Leu Ile 
             180                185                190
Arg Phe Val Pro Pro Ser Leu Ser Trp Tyr Gly Ala Tyr Leu Val Asn 
         195                200                205
Ala Tyr Pro Leu Asp Met Ser Gln Tyr Phe Arg Leu Phe Asn Ser Thr 
     210                215                220
Arg Ile Pro Arg Pro Asn Arg Asp Glu Leu Phe Thr Asp Thr Lys Ala 
 225                230                235                240
Arg His Leu Leu Val Leu Arg Lys Gly His Phe Tyr Val Phe Asp Val 
                 245                250                255
Leu Asp Gln Asp Gly Asn Ile Val Asn Pro Leu Glu Ile Gln Ala His 
             260                265                270
Leu Lys Tyr Ile Leu Ser Asp Ser Ser Pro Val Pro Glu Phe Pro Val 
         275                280                285
Ala Tyr Leu Thr Ser Glu Asn Arg Asp Val Trp Ala Glu Leu Arg Gln 
     290                295                300
Lys Leu Ile Phe Asp Gly Asn Glu Glu Thr Leu Lys Lys Val Asp Ser 
 305                310                315                320
Ala Val Phe Cys Leu Cys Leu Asp Asp Phe Pro Met Lys Asp Leu Ile 
                 325                330                335
His Leu Ser His Thr Met Leu His Gly Asp Gly Thr Asn Arg Trp Phe 
             340                345                350
Asp Lys Ser Phe Asn Leu Ile Val Ala Glu Asp Gly Thr Ala Ala Val 
         355                360                365
His Phe Glu His Ser Trp Gly Asp Gly Val Ala Val Leu Arg Phe Phe 
     370                375                380
Asn Glu Val Phe Arg Asp Ser Thr Gln Thr Pro Ala Ile Thr Pro Gln 
 385                390                395                400
Ser Gln Pro Ala Ala Thr Asn Ser Ser Ala Ser Val Glu Thr Leu Ser 
                 405                410                415
Phe Asn Leu Ser Gly Ala Leu Lys Ala Gly Ile Thr Ala Ala Lys Glu 
             420                425                430
Lys Phe Asp Thr Thr Val Lys Thr Leu Ser Ile Asp Ser Ile Gln Phe 
         435                440                445
Gln Arg Gly Gly Lys Glu Phe Leu Lys Lys Lys Gln Leu Ser Pro Asp 
     450                455                460
Ala Val Ala Gln Leu Ala Phe Gln Met Ala Phe Leu Arg Gln Tyr Gly 
 465                470                475                480
Gln Thr Val Ala Thr Tyr Glu Ser Cys Ser Thr Ala Ala Phe Lys His 
                 485                490                495
Gly Arg Thr Glu Thr Ile Arg Pro Ala Ser Ile Phe Thr Lys Arg Cys 
             500                505                510
Ser Glu Ala Phe Val Arg Asp Pro Ser Lys His Ser Val Gly Glu Leu 
         515                520                525
Gln His Met Met Ala Glu Cys Ser Lys Tyr His Gly Gln Leu Thr Lys 
     530                535                540
Glu Ala Ala Met Gly Gln Gly Phe Asp Arg His Leu Tyr Ala Leu Arg 
 545                550                555                560
Tyr Leu Ala Thr Ala Arg Gly Leu Asn Leu Pro Glu Leu Tyr Leu Asp 
                 565                570                575
Pro Ala Tyr Gln Gln Met Asn His Asn Ile Leu Ser Thr Ser Thr Leu 
             580                585                590
Asn Ser Pro Ala Val Ser Leu Gly Gly Phe Ala Pro Val Val Pro Asp 
         595                600                605
Gly Phe Gly Ile Ala Tyr Ala Val His Asp Asp Trp Ile Gly Cys Asn 
     610                615                620
Val Ser Ser Tyr Ser Gly Arg Asn Ala Arg Glu Phe Leu His Cys Val 
 625                630                635                640
Gln Lys Cys Leu Glu Asp Ile Phe Asp Ala Leu Glu Gly Lys Ala Ile 
                 645                650                655
Lys Thr 
             660



<210> 2637
<211> 2255
<212> DNA
<213> Homo sapiens
<308> M58581
<400> 2637

cctgacgca  tgtcttggg  gctaacggc  gcggcggcc  tgtgtttag  ctccagaac  60
ccccacttg  cgcgttctc  ccgccgcag  ctcccggga  gatggtgcc  cgcctgctg  120
tgcgcgcct  gccccgggg  cccgcggtt  gtccgggag  ccccagtcg  cccctcagc  180
ccggctccg  gcccggcca  tacctgcag  gcagcatcg  gcccaccat  cactaccag  240
acagcctgc  caggctgcc  attcccaaa  ttgaagaca  cattaggag  tacctcagt  300
cacagaagc  tctcttgaa  gatggccag  tcaggaaaa  agaacaatt  tgcaagagt  360
ttgaaaatg  gattggaaa  gaactgcat  agcagctgg  tgctctgga  aaacagaat  420
aacatacaa  ctacatttc  ggaccctgg  ttgatatgt  cctatctgc  cgagactcc  480
ttgttctga  ctttaatcc  tttatggct  tcaatcctg  cccaaaatc  gagtataat  540
accagctca  ccgggcaac  aacatgact  tttctgcca  ccggtttct  aagacactc  600
gggctggcc  tctggagcc  gaagtgttc  acttgaacc  tgcaaaaag  gacactatc  660
ccttcaaga  actcatacg  tttgtgcct  cctctctgt  ctggtatgg  gcctacctg  720
tcaatgcgt  tcccctgga  atgtcccag  attttcggc  tttcaactc  actcgttta  780
ccaaaccca  tcgggatga  ctcttcact  atgacaagg  cagacacct  ctggtccta  840
ggaaaggaa  tttttatat  tttgatgtc  tggatcaag  tgggaacat  gtgagcccc  900
cggaaatcc  ggcacatct  aagtacatt  tctcagaca  cagccccgc  cccgagttt  960
ccctggcat  cctgaccag  gagaaccga  acatctggg  agagctcag  cagaagctg  1020
tgagtagtg  caatgagga  agcctgagg  aagtggact  ggcagtgtt  tgtctctgc  1080
tagatgact  ccccattaa  gaccttgtc  acttgtccc  caatatgct  catggggat  1140
gcacaaacc  ctggtttga  aaatccttt  acctcatta  cgccaagga  ggctctact  1200
ccgtccact  tgagcactc  tggggtgat  gtgtggcag  gctcagatt  tttaatgaa  1260
tatttaaag  cagcactca  acccctgcc  tcactccac  gagccagcc  gctaccact  1320
actctactg  cacggtgca  aaactcaac  tcgagctga  tgatgcctt  aagactggc  1380
tcacagctg  taaggaaaa  tttgatgcc  ccatgaaaa  cctcactat  gactgcgtc  1440
agtttcaga  aggaggcaa  gaattcctg  agaagcaaa  gctgagccc  gacgcagtt  1500
cccagctgg  attccagat  gccttcctg  ggcagtacg  gcagacagt  gccacctac  1560
agtcctgta  cactgccgc  ttcaagcac  gccgcactg  gaccatccg  ccggcctcc  1620
tctatacaa  gaggtgctc  gaggccttt  tcagggagc  ctccaggca  agtgctggt  1680
agcttcagc  gatgatggt  gagtgctcc  agtaccatg  ccagctgac  aaagaagca  1740
caatgggcc  gggctttga  cgacacttg  ttgctctgc  gcatctggc  gcagccaaa  1800
ggatcatct  gcctgagct  tacctggac  ctgcatacg  gcagataaa  cacaatgtc  1860
tgtccacga  cacactgag  agcccagca  tgaaccttg  gggctttgc  cctgtggtc  1920
ctgatggct  tggtgttgg  tatgctgtt  atgacaact  gataggctg  aatgtctct  1980
cctacccag  ccgcaatgc  cgggagttt  tccaatgtg  ggagaaggc  ttagaagac  2040
tgtttgatg  cttagaagg  aaatccatc  aaagttaac  tctgggcag  tgaaaagct  2100
ccatcactt  ctcatcatg  aaactggga  gccgggcat  gtgctcatg  ctgtaatcc  2160
agcattttg  gaggctgag  cgggtggat  acttgaggt  aggagtttg  gaccaacct  2220
gccaacatg  tgaaacctt  tctctacta  aaatg  2255



<210> 2638
<211> 658
<212> PRT
<213> Homo sapiens
<308> P23786
<400> 2638

Met Val Pro Arg Leu Leu Leu Arg Ala Trp Pro Arg Gly Pro Ala Val 
  1               5                  10                  15
Gly Pro Gly Ala Pro Ser Arg Pro Leu Ser Ala Gly Ser Gly Pro Gly 
             20                  25                  30
Gln Tyr Leu Gln Arg Ser Ile Val Pro Thr Met His Tyr Gln Asp Ser 
         35                  40                  45
Leu Pro Arg Leu Pro Ile Pro Lys Leu Glu Asp Thr Ile Arg Arg Tyr 
     50                  55                  60
Leu Ser Ala Gln Lys Pro Leu Leu Asn Asp Gly Gln Phe Arg Lys Thr 
 65                  70                  75                  80
Glu Gln Phe Cys Lys Ser Phe Glu Asn Gly Ile Gly Lys Glu Leu His 
                 85                  90                  95
Glu Gln Leu Val Ala Leu Asp Lys Gln Asn Lys His Thr Ser Tyr Ile 
             100                105                110
Ser Gly Pro Trp Phe Asp Met Tyr Leu Ser Ala Arg Asp Ser Val Val 
         115                120                125
Leu Asn Phe Asn Pro Phe Met Ala Phe Asn Pro Asp Pro Lys Ser Glu 
     130                135                140
Tyr Asn Asp Gln Leu Thr Arg Ala Thr Asn Met Thr Val Ser Ala Ile 
 145                150                155                160
Arg Phe Leu Lys Thr Leu Arg Ala Gly Leu Leu Glu Pro Glu Val Phe 
                 165                170                175
His Leu Asn Pro Ala Lys Ser Asp Thr Ile Thr Phe Lys Arg Leu Ile 
             180                185                190
Arg Phe Val Pro Ser Ser Leu Ser Trp Tyr Gly Ala Tyr Leu Val Asn 
         195                200                205
Ala Tyr Pro Leu Asp Met Ser Gln Tyr Phe Arg Leu Phe Asn Ser Thr 
     210                215                220
Arg Leu Pro Lys Pro Ser Arg Asp Glu Leu Phe Thr Asp Asp Lys Ala 
 225                230                235                240
Arg His Leu Leu Val Leu Arg Lys Gly Asn Phe Tyr Ile Phe Asp Val 
                 245                250                255
Leu Asp Gln Asp Gly Asn Ile Val Ser Pro Ser Glu Ile Gln Ala His 
             260                265                270
Leu Lys Tyr Ile Leu Ser Asp Ser Ser Pro Ala Pro Glu Phe Pro Leu 
         275                280                285
Ala Tyr Leu Thr Ser Glu Asn Arg Asp Ile Trp Ala Glu Leu Arg Gln 
     290                295                300
Lys Leu Met Ser Ser Gly Asn Glu Glu Ser Leu Arg Lys Val Asp Ser 
 305                310                315                320
Ala Val Phe Cys Leu Cys Leu Asp Asp Phe Pro Ile Lys Asp Leu Val 
                 325                330                335
His Leu Ser His Asn Met Leu His Gly Asp Gly Thr Asn Arg Trp Phe 
             340                345                350
Asp Lys Ser Phe Asn Leu Ile Ile Ala Lys Asp Gly Ser Thr Ala Val 
         355                360                365
His Phe Glu His Ser Trp Gly Asp Gly Val Ala Val Leu Arg Phe Phe 
     370                375                380
Asn Glu Val Phe Lys Asp Ser Thr Gln Thr Pro Ala Val Thr Pro Gln 
 385                390                395                400
Ser Gln Pro Ala Thr Thr Asp Ser Thr Val Thr Val Gln Lys Leu Asn 
                 405                410                415
Phe Glu Leu Thr Asp Ala Leu Lys Thr Gly Ile Thr Ala Ala Lys Glu 
             420                425                430
Lys Phe Asp Ala Thr Met Lys Thr Leu Thr Ile Asp Cys Val Gln Phe 
         435                440                445
Gln Arg Gly Gly Lys Glu Phe Leu Lys Lys Gln Lys Leu Ser Pro Asp 
     450                455                460
Ala Val Ala Gln Leu Ala Phe Gln Met Ala Phe Leu Arg Gln Tyr Gly 
 465                470                475                480
Gln Thr Val Ala Thr Tyr Glu Ser Cys Ser Thr Ala Ala Phe Lys His 
                 485                490                495
Gly Arg Thr Glu Thr Ile Arg Pro Ala Ser Val Tyr Thr Lys Arg Cys 
             500                505                510
Ser Glu Ala Phe Val Arg Glu Pro Ser Arg His Ser Ala Gly Glu Leu 
         515                520                525
Gln Gln Met Met Val Glu Cys Ser Lys Tyr His Gly Gln Leu Thr Lys 
     530                535                540
Glu Ala Ala Met Gly Gln Gly Phe Asp Arg His Leu Phe Ala Leu Arg 
 545                550                555                560
His Leu Ala Ala Ala Lys Gly Ile Ile Leu Pro Glu Leu Tyr Leu Asp 
                 565                570                575
Pro Ala Tyr Gly Gln Ile Asn His Asn Val Leu Ser Thr Ser Thr Leu 
             580                585                590
Ser Ser Pro Ala Val Asn Leu Gly Gly Phe Ala Pro Val Val Ser Asp 
         595                600                605
Gly Phe Gly Val Gly Tyr Ala Val His Asp Asn Trp Ile Gly Cys Asn 
     610                615                620
Val Ser Ser Tyr Pro Gly Arg Asn Ala Arg Glu Phe Leu Gln Cys Val 
 625                630                635                640
Glu Lys Ala Leu Glu Asp Met Phe Asp Ala Leu Glu Gly Lys Ser Ile 
                 645                650                655
Lys Ser 
             660



<210> 2639
<211> 9852
<212> DNA
<213> Rattus norvegicus
<308> J05510
<400> 2639

tggggtcac  tccttcaca  aggactttg  cggaaatct  tacacccgt  tctcgtcat  60
cccttcgag  gcattaact  tttaaaacc  ggagagaaa  cgcacgccg  gaggaggtg  120
gggtgttcc  ctcccatcc  aacggaacg  gctccctct  cgcggacat  ggattgccc  180
gcggctgct  acccctgtc  tggtcctga  ccctcaaac  ggcgtggct  cccggtcac  240
aaggagctg  ctacaaagg  tttgcatcc  tggctggga  tccattggc  acagagtgc  300
tgacctggg  caggctttt  aacaaggac  tgtctgaca  aatgtctag  ttcctacat  360
tcggagaca  ttgttctct  tatgcagag  gatctacga  tggatttat  agcaccttg  420
gcttggttg  tgaccgttg  gttgtacag  cagaagctg  ggaccttaa  aatccaccc  480
agaaattca  agactgcct  tttaagcta  gtcctatga  tcgatattc  gcacagaag  540
agttctgga  agctgctaa  cccggggcc  acagtacaa  agatgcggt  ctgctcaac  600
aattgcatc  tgctgcaga  ttggaaaag  agcagaatg  gacagaaaa  aggaaattg  660
tggggacgg  catccagta  ggcaacgtg  tccagctcc  acatttgaa  agcaataaa  720
acttaactg  gaataagag  cttcctgcc  tactggaga  gaacgccat  agagtgacg  780
tggatgagg  tggaaatga  gggtcttgg  tttacattc  gccgttcta  aagctccgc  840
ccatcggag  cagtgtggt  ataggtgac  aggtagttt  gaaccctgt  aatgctggg  900
agccgctac  tgccagcag  catcagctg  tggataacc  gggctgcaa  gaggtcaac  960
ccgtcaact  taacacaag  tggaaaata  tgcttttca  gaaatggag  gataacaaa  1020
atgacattc  aaaaggagg  gatgtggta  gactcttcc  tgctgagca  gagaagttt  1080
tcacgtgcg  tgagcacag  aagaagcag  acgtcttcc  gaggacaac  ggcagacag  1140
cagccacgt  ggccaccag  tccaaagcc  tgtgggaag  ggaggtagt  cagcatgac  1200
catgtcggg  tggagctgg  tactggaat  gcctcttcc  gttcaagca  ctggctaca  1260
ggcattact  ggcagcaga  gtagaccct  actttgagg  agaatgcct  gagtttcag  1320
cctcagtgg  ccctgatca  gacgcatct  ggagcaggt  gagaaatgc  caagaaaaa  1380
tggtgtact  tctggtctc  gtgcctgag  gcaacgaca  ctcctccat  tttgagcta  1440
accccacaa  tctacgtgg  ggtgacagc  ttgtcccaa  gaactccta  gtccggctc  1500
gacacctgt  tacaaacac  tgggttcac  gcacaaaca  ccccattga  aaggaagag  1560
aaaaacctg  catgctgaa  attggtacc  ctcccctga  ggaggacaa  gaagctttt  1620
ccatagtcc  cgtttctcc  gctgaggtt  gggacctgg  ctttgccaa  gatgccagc  1680
aggtgctgg  ctccatcgc  gggaagttg  aaaagggca  catcaccca  aatgagaga  1740
ggtctgtca  caagctgct  gaagacttg  tttactttg  cacgggtgg  acgaactct  1800
gccaagacg  gcttgaagt  gtcttctct  agcccaacc  agagcggca  aagctgatg  1860
gggaacaga  tattctcaa  cagatcttc  agcttttgc  ggccccctt  acggactgc  1920
gggatggcc  aatgcttcg  ctggaggag  tgggggacc  gcggcacgc  cctttcaga  1980
acatttgcc  actctgcta  agggtcctg  gacactcac  gcaagacta  aggaagaac  2040
aggagtaca  agccaagca  tttggcttc  tgcagaagc  gattggcta  gatgtgctg  2100
ccgaagaca  catcactgc  ctgctccac  acaaccgaa  gctcctgga  aagcacatc  2160
ccgcagcag  gattgacac  tttgtcagc  tggtgcgaa  gaacaggga  cccaggttc  2220
tggattacc  ctctgacct  tgtgtatcc  tgaataagt  aatccctgt  acccaggag  2280
tcatttgta  agctgtgct  aatcccacc  atgctgaca  cctgattga  accaagttg  2340
ttctttctc  ttttgagtt  gaaggcgtt  ccaccggag  gaatgctct  gaagctggg  2400
aagatgagg  agaggtgtg  ctgttctgg  gggacagca  caaagagat  cgtagcaag  2460
gtgttaggg  attggcaca  gatgctaaa  agggacaga  ggaagacag  gatgtcctc  2520
gctactaca  gtatcagct  aacctcttt  caaggatgt  tctggaccg  cagtacctg  2580
ccatcaatg  aatatccgg  cagctggat  ttgacctca  cctccgctg  atgtccgat  2640
agaacctcc  ctatgacct  agagcatcc  tttgccgcc  catgcttca  atgcatgtg  2700
accgagatc  ccaggagca  gtgacccct  tgaaatacg  ccgtctgtg  tcagaaatt  2760
cctccgaga  cgccattga  gactatgac  gcagtggag  atcgaagga  gaaatcaag  2820
agaggtttg  tcagacgat  gagtttgtg  aggagtacc  gagagatgt  gtttgtcaa  2880
gattcccct  ttctgataa  gagaaaaat  agctcacat  tgaggttgt  aacttagcc  2940
ggaacctca  atactttgg  ttctacaac  tttctgacc  tctccgatt  accaagatc  3000
tcttggcaa  cttagactg  gttcatgtg  caaccatct  ccccattag  aagatgacg  3060
aaggcgaag  gaataaagg  agcaacgtg  tgagatcta  ccatggagt  ggggagctc  3120
tgacccagg  ggtgcttcg  ggaggaggc  ttttgccca  gactcctat  gctgctgcc  3180
ctgaaggaa  tgtgaagca  gcagagcca  agaaagagg  tatcatggt  atggacacc  3240
agttaaaga  cattgaaat  ctccagttt  ttttgaatg  gagattgga  tataggatc  3300
cctgcctcc  gtgtatatt  aagcgggag  ttgatgaaa  caattccca  tcatcagaa  3360
catcctccg  aaacagcag  caagaaggg  caagtaatg  accaggtgc  cttgacttt  3420
aacacattg  agagcaagc  gaaggcatc  ttgggggaa  tgaggagaa  acacctctg  3480
acttggatg  tcatggtgg  agaaccttc  tcagggtcc  gctccactt  acaatgcat  3540
attacccac  cctggtgtc  ggggccctg  agctcctct  ccggcattt  agccagagg  3600
aggaggtcc  tcaggcctt  aaacaggtt  aactgctgg  tactagcca  gatgtggac  3660
actacaaac  gatcaagca  gacttggac  agctaagat  catcgtgga  aagtctgag  3720
tctgggtat  caaaggcca  ggtcccgat  agcctatgg  cggagcctc  ggtgaaaac  3780
aacataaga  aactgagga  gggaccagt  agccactga  gcacgaaag  accagcagc  3840
acaactacc  agtggtgaa  gagattctg  ttcgactta  caagctctg  gttcaagag  3900
gcgcgtcgg  gaggaagag  aggaagcag  agcagcgac  gctgaggaa  atgggtgcc  3960
atgctgtgg  gctggagct  ctgcagatc  cctatgaga  ggccgaaga  accaagatg  4020
aggagatca  gaggctggc  cacgaattt  tgcagaatt  ctgcgcagg  aaccagcag  4080
accaagctt  gctacataa  cacataaac  tgtttctca  cccagggat  ctggaagca  4140
tgaccatgc  gcacatctt  atgaacaac  tccagctgt  cagtgagat  aacgagaga  4200
tggtccagc  tttcgttca  tgcatagag  cccacggtc  aaatgtcca  tatatcaag  4260
ttctccaga  tattgtcaa  gccgaaggg  aattcatta  aaagtgcca  gacatggtc  4320
tggctgagc  tgtcaattc  ggagaggac  tcctcgtgt  ctacaatga  agagcctct  4380
tccagactc  gatccagat  atgcggtcc  agcgtgacc  gatggatga  aacagccct  4440
tcttcatgt  ccacatcca  ctggtggag  tcttggctg  gtgcacaga  ggcaagaat  4500
tgtacacag  gatcaagtg  aactccctg  tcccgctcg  tgacatcgt  cgtgtggtc  4560
ctcatgaag  ctgtatccc  gaggttaag  ttgcttaca  caacttcct  aatcactgc  4620
atgtggaca  tgaggtgga  atgaaggag  tttacacaa  taatcacat  tggaagttg  4680
ttgagaatt  cctcgtgga  atctgcagg  cctgtaaca  cacaagtga  aggaagcat  4740
cagactcgg  tctggagaa  tacgtcact  aaatcgtga  gagcattgt  accaccttc  4800
tcagctctc  cttctcaga  cagagtacc  ctctgcaga  tcgccagcc  gtctttgtg  4860
agctcctgc  aggcgtgtt  cgagtttac  actgcaact  gttgatgcc  agccagaaa  4920
cctcggtgg  gagctgtat  cgcgtgctc  ctgacgtag  caagagccg  gccatagcc  4980
ttcctgttg  cctagacag  caagtcaac  acctcttcc  gaagtccca  aacattgtg  5040
agaaaacag  catgaactg  cggttatca  cccgcaacg  tgctcgtag  gactctgtc  5100
tggcagctt  cagagacta  cgaaatatt  ttgagaggt  acaggacat  gtgtctgcc  5160
tggaggacc  actcaggcc  ctggtccag  ccgagctgt  tgtgctcgt  gatgttcta  5220
acagaccgg  actgctttt  cctgagaac  cggatgcca  gaggaaatg  gaaagtgga  5280
gtttcatct  caagctcat  aaacacacc  agcagctgc  agaggagaa  gaagagaaa  5340
tgtgcatta  agtcttaca  accctcagg  aaatgatga  caaagatag  ggctatgga  5400
aaaagcaaa  ttccattga  gaattggaa  atgccgagc  gccacagcc  ccggaagct  5460
agaactcca  agaggagct  gaaccaagt  cacccctga  gcaactgga  gaccataaa  5520
ggggtgagg  actccggca  attttggtc  accgttact  tggaaacat  agaccttca  5580
gaagaagag  gagccttac  agctttggc  atggtccac  atcaccagg  ggacccagc  5640
agcctgggg  aggaggggg  ggtcctggg  ccggctcca  aagccgggg  gagatgagc  5700
tggctgagg  tcaatgtca  ctcgacaag  aaggcgcct  caatctggt  atcgacctc  5760
taatgaatg  atccagcga  cgagtattc  acgaaagca  tctcctggc  atcgcactt  5820
tggaaggag  caacaccac  atccagcac  catttttct  ccggctgac  gaagataag  5880
aatcagaga  gttcttcaa  gtcttttac  atcgaatga  ggtggccca  caggaaatc  5940
aggcgacag  gaccgtgaa  accagcgat  tgggaaaca  aaagaaaga  gatgaagtg  6000
accgggatg  cccatcccg  aagaaagcc  aagagccca  aacacagat  acagaagag  6060
tccgggatc  gctcttgga  gcatctgct  ccaccagaa  agcctttac  accttccgg  6120
gggaggccg  ccctgatga  cattaccaa  ctggggagg  cacccaggc  acaacggac  6180
aagccaagg  tgacctaga  atgagtgca  tcatcacca  catgcagcc  atcctgcgc  6240
tcctgcagc  cctgtgtga  aaccacaac  gcgatctgc  gaatttcct  cgttgccaa  6300
ataataaga  caactacaa  ttggtgtgt  agacactgc  gtttctgga  tgtatctgt  6360
ggagcacaa  tggaggcct  ggtcttctc  gactgtaca  aaatgaaaa  aatgtagct  6420
ttatcaacc  aaccctgga  agtctgact  agtactgtc  agggccttg  catgaaaac  6480
agaactgca  cgccaccca  gagtccaat  gcatcgata  catcacagc  ctcatcctt  6540
acgatatca  ccctctggg  aagaaacgg  tggacctgg  gttagaact  aagaacaat  6600
cttcaaagc  actcctggc  atcatggaa  gcagacacg  tagtgaaaa  gcagagagg  6660
tcctgtaca  catgaggcc  aaggagctg  tggaagtga  caagaaggc  tacatgcaa  6720
gcgaagtgg  gtttgagga  ggggagaac  gtgaggatg  agcagcctc  cccaggaac  6780
tgggccata  catctacat  ctcgctcac  agttggctc  gcataacaa  gaacttcaa  6840
ccatgctga  acctggagg  caggtggat  gcgatgaag  tctggagtt  tatgcgaag  6900
acacagcac  aattgagat  gtcagactg  accgaacta  ggaacagat  gtcttccct  6960
tgcccagca  ctgtgaatt  ctgactaag  aatcgaaac  tcgaatata  tacaccaca  7020
agagggatg  gcaaggcag  aagatcaat  acttcttcc  gcgctccga  gacctcttt  7080
atgagatga  ctggcagaa  aaacttcga  cccagcctg  cttgtactg  tgcgcccga  7140
acatgtctt  ctggagcag  atctccttc  acctggccg  cctgatgaa  ctgctggtg  7200
cgtttttct  cccatttaa  ggagtgaga  gaggaacac  agagccgca  tggtccggc  7260
tcctgtgga  agccatgct  atctctctg  caattgtca  tgcgctgcc  aagccccat  7320
gcatccggg  cttaattgc  tctacaatc  tacgactga  attttcagt  ggattacag  7380
ccacactgt  tctgctggg  gctttcaat  tctgcaata  aatcatctt  ctgatgagc  7440
ttgtgggca  ctgtgggac  ttcaccaga  gctaccgag  catggttct  gacgttgag  7500
tcctctatc  tttgctgta  ctactgatc  gtgccatgg  cctcttcgt  catgagttt  7560
tctatagtt  gctgctttt  gatttagtg  acagagagg  gactttgct  aatgtcatt  7620
aaagtgtca  ccgcaatgg  cggcccatc  tcttgacag  ggccctggc  ctgattctg  7680
tttacctgt  ctcaattgt  ggctacctg  tcttcaagg  tgactttat  ttggaagta  7740
acaggttgc  caatgagac  gctggtcca  aaactggtg  gagtttggc  aacgatttc  7800
tgtactctg  tgtgtgccg  gtagagacg  gggagaact  cacctctcc  gcacccaaa  7860
aagagctgc  ccctgtgga  gaaacggaa  aggataagg  gcacacgtg  gagacactg  7920
tcatgtgca  cgtcaccgt  ctgagtcac  ggctgcgga  tgggggcgg  gtaggagat  7980
tgctcagga  gccatccaa  gaggagcct  tgtttgctg  aagggtgat  tatgacctc  8040
tcttcttct  catggtcat  atcattgtc  tgaacctca  ttttggggt  atcatcgac  8100
cctttgctg  cctgaggag  gagaagcag  agaaggaag  gatcttaaa  accacgtgc  8160
tcatttgtg  cttggaaag  gacaagttt  acaataaga  cgtcacctt  gaagagcac  8220
ttaaggaag  acacaacat  tggcactat  tgtgcttca  cgtgctggt  aaagtgaag  8280
actccaccg  gtacaccgg  cccgagagc  acgtggcag  gatgatcag  gaaagaaac  8340
ttgattggt  ccccaggat  agagccatg  ccctggtca  cagtgactc  gaaggggaa  8400
agaacgagc  gaggaacct  caggagaag  tggagtcca  catgaagct  gtcaccaat  8460
tttctggcc  gctgtcaga  ctaaaggac  agatgacag  acaaaggaa  cagaaacaa  8520
gaattggcc  tctaggaca  cctcctcac  tgaatgtca  cccacagca  ccagcctaa  8580
caaatgaga  ggagggact  tactcaacc  tttttaaat  attgtcagc  tgggtctgg  8640
tcttggttc  gatctgccc  ctaaggtta  atgtgcgct  agtacattt  taaatactc  8700
gttttgtat  gtatgtata  gattgcaat  ctcagaggt  tggactttc  tattgtaat  8760
agctctgtt  gcatggtga  ttgtcactc  tgccaaaaa  attaaaaat  ccttttttg  8820
aaggactac  gaaagtacc  gatttgcac  tgaaccaga  tatagattt  aaaagtatt  8880
gacatgtat  ttgttattt  aaactagaa  agccagtat  tatgttttt  ataaaactg  8940
gcaatacaa  ttatgcaat  accataact  tgtaactcc  gagtgtctt  agggagtgc  9000
catctttga  gctgatctg  taatactta  gtaataaat  gttaaatat  aaatgatga  9060
gctgctgcc  aaattatat  aatagcaag  ttctggccc  tgggcaatt  tgtaccttg  9120
aattatcct  tggtgatgc  gtttctcgt  gctaatggc  ttagtgcct  gtatcctag  9180
gataactcc  ggtctgtga  ccattcaaa  aacattcat  tttgagaca  agcaacttt  9240
gtttcaagg  taattttaa  cttcaaaat  aatcattta  agtatttct  taagagagc  9300
atgttagag  ctcacacgt  agcttgaaa  gagtcgatg  aataatttt  ttaaaggga  9360
ctttttaca  gacgtttgg  ataacagca  attgctgac  agtcagtgt  atctcccag  9420
tgaattttg  tgtcacgtt  tagtcaaat  agctagctt  tggtttcta  attctcttc  9480
tctgaacca  catgatgca  taggtgaga  gttattatg  atatataca  atatacatc  9540
atataaggc  aagtaggag  tgtcccctt  ggatgcata  ctgccccct  agggtgcag  9600
gctcaacac  gacagtgct  ttctgagag  gccacgttt  ggttttatt  ctttgtcac  9660
tgatttctt  tctggatgt  tgcaagtat  acaggaagt  ttttctacc  gttgcttgt  9720
ttgtacctg  gtctcgttt  actagacca  ctctgcaca  aagtttaaa  aatgaaccg  9780
aagcagagt  ctgaagcaa  tcaagtttg  aagtgcata  ctgaaatta  ttaataaat  9840
acgcagaat  ct  9852



<210> 2640
<211> 2750
<212> PRT
<213> Rattus norvegicus
<308> P29994
<400> 2640

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
  1               5                  10                  15
Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
             20                  25                  30
Val Asp Asp Arg Cys Val Val Gln Pro Glu Ala Gly Asp Leu Asn Asn 
         35                  40                  45
Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
     50                  55                  60
Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
 65                  70                  75                  80
Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                 85                  90                  95
Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
             100                105                110
Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
         115                120                125
Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
     130                135                140
Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
 145                150                155                160
Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                 165                170                175
Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
             180                185                190
Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
         195                200                205
Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
     210                215                220
Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
 225                230                235                240
Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                 245                250                255
Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
             260                265                270
Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
         275                280                285
His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
     290                295                300
Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
 305                310                315                320
Asp Phe Glu Glu Glu Cys Leu Glu Phe Gln Pro Ser Val Asp Pro Asp 
                 325                330                335
Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met Val 
             340                345                350
Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile Phe 
         355                360                365
Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro Arg 
     370                375                380
Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val His 
 385                390                395                400
Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met Leu 
                 405                410                415
Lys Ile Gly Thr Ser Pro Leu Lys Glu Asp Lys Glu Ala Phe Ala Ile 
             420                425                430
Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn Asp 
         435                440                445
Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly Thr 
     450                455                460
Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp Leu 
 465                470                475                480
Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu Glu 
                 485                490                495
Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu 
             500                505                510
Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe Thr 
         515                520                525
Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp Gln 
     530                535                540
Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val Leu 
 545                550                555                560
Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala Lys 
                 565                570                575
Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala Glu 
             580                585                590
Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
         595                600                605
His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg Lys 
     610                615                620
Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
 625                630                635                640
Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala Val 
                 645                650                655
Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val Leu 
             660                665                670
Ser Arg Phe Glu Phe Glu Gly Val Ser Thr Gly Glu Asn Ala Leu Glu 
         675                680                685
Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp Ser Asn 
     690                695                700
Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp Ala Lys 
 705                710                715                720
Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg Tyr Gln 
                 725                730                735
Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala Ile 
             740                745                750
Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg Cys Met 
         755                760                765
Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys Arg Leu 
     770                775                780
Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val Thr Pro 
 785                790                795                800
Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile Ala Ile 
                 805                810                815
Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys Glu Arg 
             820                825                830
Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp Val Val 
         835                840                845
Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu Thr Phe 
     850                855                860
Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe Tyr Asn 
 865                870                875                880
Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile Leu Asp 
                 885                890                895
Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Thr Lys Gly 
             900                905                910
Glu Glu Asn Lys Gly Ser Asn Val Met Arg Ser Ile His Gly Val Gly 
         915                920                925
Glu Leu Met Thr Gln Val Val Leu Arg Gly Gly Gly Phe Leu Pro Met 
     930                935                940
Thr Pro Met Ala Ala Ala Pro Glu Gly Asn Val Lys Gln Ala Glu Pro 
 945                950                955                960
Glu Lys Glu Asp Ile Met Val Met Asp Thr Lys Leu Lys Ile Ile Glu 
                 965                970                975
Ile Leu Gln Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile Ser Cys 
             980                985                990
Leu Leu Cys Ile Phe Lys Arg Glu Phe Asp Glu Ser Asn Ser Gln Ser 
         995                1000                1005
Ser Glu Thr Ser Ser Gly Asn Ser Ser Gln Glu Gly Pro Ser Asn Val 
     1010                1015                1020
Pro Gly Ala Leu Asp Phe Glu His Ile Glu Glu Gln Ala Glu Gly Ile 
 1025                1030                1035                1040
Phe Gly Gly Ser Glu Glu Asn Thr Pro Leu Asp Leu Asp Asp His Gly 
                 1045                1050                1055
Gly Arg Thr Phe Leu Arg Val Leu Leu His Leu Thr Met His Asp Tyr 
             1060                1065                1070
Pro Pro Leu Val Ser Gly Ala Leu Gln Leu Leu Phe Arg His Phe Ser 
         1075                1080                1085
Gln Arg Gln Glu Val Leu Gln Ala Phe Lys Gln Val Gln Leu Leu Val 
     1090                1095                1100
Thr Ser Gln Asp Val Asp Asn Tyr Lys Gln Ile Lys Gln Asp Leu Asp 
 1105                1110                1115                1120
Gln Leu Arg Ser Ile Val Glu Lys Ser Glu Leu Trp Val Tyr Lys Gly 
                 1125                1130                1135
Gln Gly Pro Asp Glu Pro Met Asp Gly Ala Ser Gly Glu Asn Glu His 
             1140                1145                1150
Lys Lys Thr Glu Glu Gly Thr Ser Lys Pro Leu Lys His Glu Ser Thr 
         1155                1160                1165
Ser Ser Tyr Asn Tyr Arg Val Val Lys Glu Ile Leu Ile Arg Leu Ser 
     1170                1175                1180
Lys Leu Cys Val Gln Glu Ser Ala Ser Val Arg Lys Ser Arg Lys Gln 
 1185                1190                1195                1200
Gln Gln Arg Leu Leu Arg Asn Met Gly Ala His Ala Val Val Leu Glu 
                 1205                1210                1215
Leu Leu Gln Ile Pro Tyr Glu Lys Ala Glu Asp Thr Lys Met Gln Glu 
             1220                1225                1230
Ile Met Arg Leu Ala His Glu Phe Leu Gln Asn Phe Cys Ala Gly Asn 
         1235                1240                1245
Gln Gln Asn Gln Ala Leu Leu His Lys His Ile Asn Leu Phe Leu Asn 
     1250                1255                1260
Pro Gly Ile Leu Glu Ala Val Thr Met Gln His Ile Phe Met Asn Asn 
 1265                1270                1275                1280
Phe Gln Leu Cys Ser Glu Ile Asn Glu Arg Val Val Gln His Phe Val 
                 1285                1290                1295
His Cys Ile Glu Thr His Gly Arg Asn Val Gln Tyr Ile Lys Phe Leu 
             1300                1305                1310
Gln Thr Ile Val Lys Ala Glu Gly Lys Phe Ile Lys Lys Cys Gln Asp 
         1315                1320                1325
Met Val Met Ala Glu Leu Val Asn Ser Gly Glu Asp Val Leu Val Phe 
     1330                1335                1340
Tyr Asn Asp Arg Ala Ser Phe Gln Thr Leu Ile Gln Met Met Arg Ser 
 1345                1350                1355                1360
Glu Arg Asp Arg Met Asp Glu Asn Ser Pro Leu Phe Met Tyr His Ile 
                 1365                1370                1375
His Leu Val Glu Leu Leu Ala Val Cys Thr Glu Gly Lys Asn Val Tyr 
             1380                1385                1390
Thr Glu Ile Lys Cys Asn Ser Leu Leu Pro Leu Asp Asp Ile Val Arg 
         1395                1400                1405
Val Val Thr His Glu Asp Cys Ile Pro Glu Val Lys Ile Ala Tyr Ile 
     1410                1415                1420
Asn Phe Leu Asn His Cys Tyr Val Asp Thr Glu Val Glu Met Lys Glu 
 1425                1430                1435                1440
Ile Tyr Thr Ser Asn His Met Trp Lys Leu Phe Glu Asn Phe Leu Val 
                 1445                1450                1455
Asp Ile Cys Arg Ala Cys Asn Asn Thr Ser Asp Arg Lys His Ala Asp 
             1460                1465                1470
Ser Val Leu Glu Lys Tyr Val Thr Glu Ile Val Met Ser Ile Val Thr 
         1475                1480                1485
Thr Phe Phe Ser Ser Pro Phe Ser Asp Gln Ser Thr Thr Leu Gln Thr 
     1490                1495                1500
Arg Gln Pro Val Phe Val Gln Leu Leu Gln Gly Val Phe Arg Val Tyr 
 1505                1510                1515                1520
His Cys Asn Trp Leu Met Pro Ser Gln Lys Ala Ser Val Glu Ser Cys 
                 1525                1530                1535
Ile Arg Val Leu Ser Asp Val Ala Lys Ser Arg Ala Ile Ala Ile Pro 
             1540                1545                1550
Val Asp Leu Asp Ser Gln Val Asn Asn Leu Phe Leu Lys Ser His Asn 
         1555                1560                1565
Ile Val Gln Lys Thr Ala Met Asn Trp Arg Leu Ser Ala Arg Asn Ala 
     1570                1575                1580
Ala Arg Arg Asp Ser Val Leu Ala Ala Ser Arg Asp Tyr Arg Asn Ile 
 1585                1590                1595                1600
Ile Glu Arg Leu Gln Asp Ile Val Ser Ala Leu Glu Asp Arg Leu Arg 
                 1605                1610                1615
Pro Leu Val Gln Ala Glu Leu Ser Val Leu Val Asp Val Leu His Arg 
             1620                1625                1630
Pro Glu Leu Leu Phe Pro Glu Asn Thr Asp Ala Arg Arg Lys Cys Glu 
         1635                1640                1645
Ser Gly Gly Phe Ile Cys Lys Leu Ile Lys His Thr Lys Gln Leu Leu 
     1650                1655                1660
Glu Glu Asn Glu Glu Lys Leu Cys Ile Lys Val Leu Gln Thr Leu Arg 
 1665                1670                1675                1680
Glu Met Met Thr Lys Asp Arg Gly Tyr Gly Glu Lys Gln Ile Ser Ile 
                 1685                1690                1695
Asp Glu Leu Glu Asn Ala Glu Leu Pro Gln Pro Pro Glu Ala Glu Asn 
             1700                1705                1710
Ser Thr Glu Gln Glu Leu Glu Pro Ser Pro Pro Leu Arg Gln Leu Glu 
         1715                1720                1725
Asp His Lys Arg Gly Glu Ala Leu Arg Gln Ile Leu Val Asn Arg Tyr 
     1730                1735                1740
Tyr Gly Asn Ile Arg Pro Ser Gly Arg Arg Glu Ser Leu Thr Ser Phe 
 1745                1750                1755                1760
Gly Asn Gly Pro Leu Ser Pro Gly Gly Pro Ser Lys Pro Gly Gly Gly 
                 1765                1770                1775
Gly Gly Gly Pro Gly Ser Gly Ser Thr Ser Arg Gly Glu Met Ser Leu 
             1780                1785                1790
Ala Glu Val Gln Cys His Leu Asp Lys Glu Gly Ala Ser Asn Leu Val 
         1795                1800                1805
Ile Asp Leu Ile Met Asn Ala Ser Ser Asp Arg Val Phe His Glu Ser 
     1810                1815                1820
Ile Leu Leu Ala Ile Ala Leu Leu Glu Gly Gly Asn Thr Thr Ile Gln 
 1825                1830                1835                1840
His Ser Phe Phe Cys Arg Leu Thr Glu Asp Lys Lys Ser Glu Lys Phe 
                 1845                1850                1855
Phe Lys Val Phe Tyr Asp Arg Met Lys Val Ala Gln Gln Glu Ile Lys 
             1860                1865                1870
Ala Thr Val Thr Val Asn Thr Ser Asp Leu Gly Asn Lys Lys Lys Asp 
         1875                1880                1885
Asp Glu Val Asp Arg Asp Ala Pro Ser Arg Lys Lys Ala Lys Glu Pro 
     1890                1895                1900
Thr Thr Gln Ile Thr Glu Glu Val Arg Asp Gln Leu Leu Glu Ala Ser 
 1905                1910                1915                1920
Ala Ala Thr Arg Lys Ala Phe Thr Thr Phe Arg Arg Glu Ala Asp Pro 
                 1925                1930                1935
Asp Asp His Tyr Gln Ser Gly Glu Gly Thr Gln Ala Thr Thr Asp Lys 
             1940                1945                1950
Ala Lys Asp Asp Leu Glu Met Ser Ala Val Ile Thr Ile Met Gln Pro 
         1955                1960                1965
Ile Leu Arg Phe Leu Gln Leu Leu Cys Glu Asn His Asn Arg Asp Leu 
     1970                1975                1980
Gln Asn Phe Leu Arg Cys Gln Asn Asn Lys Thr Asn Tyr Asn Leu Val 
 1985                1990                1995                2000
Cys Glu Thr Leu Gln Phe Leu Asp Cys Ile Cys Gly Ser Thr Thr Gly 
                 2005                2010                2015
Gly Leu Gly Leu Leu Gly Leu Tyr Ile Asn Glu Lys Asn Val Ala Leu 
             2020                2025                2030
Ile Asn Gln Thr Leu Glu Ser Leu Thr Glu Tyr Cys Gln Gly Pro Cys 
         2035                2040                2045
His Glu Asn Gln Asn Cys Ile Ala Thr His Glu Ser Asn Gly Ile Asp 
     2050                2055                2060
Ile Ile Thr Ala Leu Ile Leu Asn Asp Ile Asn Pro Leu Gly Lys Lys 
 2065                2070                2075                2080
Arg Met Asp Leu Val Leu Glu Leu Lys Asn Asn Ala Ser Lys Leu Leu 
                 2085                2090                2095
Leu Ala Ile Met Glu Ser Arg His Asp Ser Glu Asn Ala Glu Arg Ile 
             2100                2105                2110
Leu Tyr Asn Met Arg Pro Lys Glu Leu Val Glu Val Ile Lys Lys Ala 
         2115                2120                2125
Tyr Met Gln Gly Glu Val Glu Phe Glu Asp Gly Glu Asn Gly Glu Asp 
     2130                2135                2140
Gly Ala Ala Ser Pro Arg Asn Val Gly His Asn Ile Tyr Ile Leu Ala 
 2145                2150                2155                2160
His Gln Leu Ala Arg His Asn Lys Glu Leu Gln Thr Met Leu Lys Pro 
                 2165                2170                2175
Gly Gly Gln Val Asp Gly Asp Glu Ala Leu Glu Phe Tyr Ala Lys His 
             2180                2185                2190
Thr Ala Gln Ile Glu Ile Val Arg Leu Asp Arg Thr Met Glu Gln Ile 
         2195                2200                2205
Val Phe Pro Val Pro Ser Ile Cys Glu Phe Leu Thr Lys Glu Ser Lys 
     2210                2215                2220
Leu Arg Ile Tyr Tyr Thr Thr Glu Arg Asp Glu Gln Gly Ser Lys Ile 
 2225                2230                2235                2240
Asn Asp Phe Phe Leu Arg Ser Glu Asp Leu Phe Asn Glu Met Asn Trp 
                 2245                2250                2255
Gln Lys Lys Leu Arg Ala Gln Pro Val Leu Tyr Trp Cys Ala Arg Asn 
             2260                2265                2270
Met Ser Phe Trp Ser Ser Ile Ser Phe Asn Leu Ala Val Leu Met Asn 
         2275                2280                2285
Leu Leu Val Ala Phe Phe Tyr Pro Phe Lys Gly Val Arg Gly Gly Thr 
     2290                2295                2300
Leu Glu Pro His Trp Ser Gly Leu Leu Trp Thr Ala Met Leu Ile Ser 
 2305                2310                2315                2320
Leu Ala Ile Val Ile Ala Leu Pro Lys Pro His Gly Ile Arg Ala Leu 
                 2325                2330                2335
Ile Ala Ser Thr Ile Leu Arg Leu Ile Phe Ser Val Gly Leu Gln Pro 
             2340                2345                2350
Thr Leu Phe Leu Leu Gly Ala Phe Asn Val Cys Asn Lys Ile Ile Phe 
         2355                2360                2365
Leu Met Ser Phe Val Gly Asn Cys Gly Thr Phe Thr Arg Gly Tyr Arg 
     2370                2375                2380
Ala Met Val Leu Asp Val Glu Phe Leu Tyr His Leu Leu Tyr Leu Leu 
 2385                2390                2395                2400
Ile Cys Ala Met Gly Leu Phe Val His Glu Phe Phe Tyr Ser Leu Leu 
                 2405                2410                2415
Leu Phe Asp Leu Val Tyr Arg Glu Glu Thr Leu Leu Asn Val Ile Lys 
             2420                2425                2430
Ser Val Thr Arg Asn Gly Arg Pro Ile Ile Leu Thr Ala Ala Leu Ala 
         2435                2440                2445
Leu Ile Leu Val Tyr Leu Phe Ser Ile Val Gly Tyr Leu Phe Phe Lys 
     2450                2455                2460
Asp Asp Phe Ile Leu Glu Val Asp Arg Leu Pro Asn Glu Thr Ala Gly 
 2465                2470                2475                2480
Pro Glu Thr Gly Glu Ser Leu Ala Asn Asp Phe Leu Tyr Ser Asp Val 
                 2485                2490                2495
Cys Arg Val Glu Thr Gly Glu Asn Cys Thr Ser Pro Ala Pro Lys Glu 
             2500                2505                2510
Glu Leu Leu Pro Val Glu Glu Thr Glu Gln Asp Lys Glu His Thr Cys 
         2515                2520                2525
Glu Thr Leu Leu Met Cys Ile Val Thr Val Leu Ser His Gly Leu Arg 
     2530                2535                2540
Ser Gly Gly Gly Val Gly Asp Val Leu Arg Lys Pro Ser Lys Glu Glu 
 2545                2550                2555                2560
Pro Leu Phe Ala Ala Arg Val Ile Tyr Asp Leu Leu Phe Phe Phe Met 
                 2565                2570                2575
Val Ile Ile Ile Val Leu Asn Leu Ile Phe Gly Val Ile Ile Asp Thr 
             2580                2585                2590
Phe Ala Asp Leu Arg Ser Glu Lys Gln Lys Lys Glu Glu Ile Leu Lys 
         2595                2600                2605
Thr Thr Cys Phe Ile Cys Gly Leu Glu Arg Asp Lys Phe Asp Asn Lys 
     2610                2615                2620
Thr Val Thr Phe Glu Glu His Ile Lys Glu Glu His Asn Met Trp His 
 2625                2630                2635                2640
Tyr Leu Cys Phe Ile Val Leu Val Lys Val Lys Asp Ser Thr Glu Tyr 
                 2645                2650                2655
Thr Gly Pro Glu Ser Tyr Val Ala Glu Met Ile Arg Glu Arg Asn Leu 
             2660                2665                2670
Asp Trp Phe Pro Arg Met Arg Ala Met Ser Leu Val Ser Ser Asp Ser 
         2675                2680                2685
Glu Gly Glu Gln Asn Glu Leu Arg Asn Leu Gln Glu Lys Leu Glu Ser 
     2690                2695                2700
Thr Met Lys Leu Val Thr Asn Leu Ser Gly Gln Leu Ser Glu Leu Lys 
 2705                2710                2715                2720
Asp Gln Met Thr Glu Gln Arg Lys Gln Lys Gln Arg Ile Gly Leu Leu 
                 2725                2730                2735
Gly His Pro Pro His Met Asn Val Asn Pro Gln Gln Pro Ala 
             2740                2745                2750



<210> 2641
<211> 9517
<212> DNA
<213> Homo sapiens
<308> D26070
<400> 2641

gttgctgtc  gagagagaa  gccgcaccc  agaggaggt  tgggtgttc  gcttccatc  60
taacggaac  agctccctc  tcgcggaca  gggattacc  agcggctgc  aacccctct  120
ctcgccctg  tcccccaaa  cggcgtggc  ccccgggca  caaggagct  actacagag  180
agcaggatt  gcacccctc  ctgggcttg  tttggcaac  gagtgcctg  cccaggtca  240
gattttcaa  aaagacatg  ctgacaaaa  gtctagctt  ctacatatt  gagacattt  300
ttctctgta  gcggaggga  cgacaaatg  atttattag  accttgggc  tggttgatg  360
tcgttgtgt  gtacagcca  aaaccgggg  ccttaacaa  ccacctaag  aattcagag  420
ctgcctctt  aagctatgt  ccatgaacc  ctactctgc  caaaagcag  tctggaaag  480
cgctaagcc  ggggccaac  gcaccacag  cgcagtgct  ctcaacaaa  tgcaccacg  540
tgcagactt  gaaaagaag  agaatgaga  agaaaacag  aaattgctg  ggaccgtaa  600
ccagtatgg  aatgtgatc  agctcctgc  tttgaaaag  aataaatac  taacagtga  660
taagaggct  cctgctctg  tggagaaga  tgccatgag  gtcacattg  acgaggctg  720
aaatgaagg  tcctggttt  atattcagc  attctacaa  ctgcgatcc  ttggagaca  780
cgtggtcat  ggtgacaag  tggttctga  ccccgtcaa  gctggtcag  ccctacatg  840
tagcagcca  caactggta  ataacccag  ctgcaatga  gtcaattcc  tcaactgca  900
tacaagctg  aaaatagtc  ttttcatga  atggagtga  aacaaagac  acatattaa  960
ggggggtga  gtggtgagg  tgtttcatg  tgagcagga  aagtttctc  cctgtgacg  1020
acacaggaa  aagcagcac  tcttcctga  aaccacggg  cggcagtcg  ccacatctg  1080
caccagttc  aaagccctg  gggaggtgg  ggtggtcca  catgaccca  gtcggggcg  1140
agcagggta  tggaacagc  ttttccgtt  caagcatct  gccacgggg  attacttgg  1200
agcagaggt  gaccctgat  aggacgcct  tcgaagtag  ttgcggaat  cccaagaaa  1260
gatggtata  tccctggtc  ctgtgcctg  aggcaatga  atctcctcc  ttttcgagc  1320
agatcccac  actctgcgt  gaggtgaca  ccttgtccc  aggaactct  atgttcggc  1380
cagacacct  tgtactaat  cctgggttc  cagcacaaa  attcctatt  acaaggaag  1440
agaaaagcc  gtgatgctg  aaattggca  ctctcctgt  aaggaggat  aggaagcat  1500
tgccatagt  ccggtttct  ctgctgaag  tcgggacct  gactttgcc  atgatgcca  1560
caaggtgct  ggctccatt  ctgggaagc  agagaaggg  accatcacc  agaatgaaa  1620
gaggtctgt  accaagctg  tagaagatt  ggtttactt  gtcactggt  gaactaatt  1680
tggtcaaga  gttctcgaa  ttgtcttct  caagcccaa  agagaacgg  agaaactga  1740
gagagaaca  aatattctc  agcagatct  caagttgtt  caagcccca  tcacagact  1800
cggtgatgg  ccaatgctt  ggctggaag  gctcgggga  cagcggcac  ctcctttca  1860
acacatctg  cggctctgc  acagggtgc  gagacactc  cagcaagac  acaggaaga  1920
ccaggagta  atagccaag  agtttggct  catgcagaa  cagattggc  atgatgtgt  1980
ggctgaaga  actatcact  ccctgctcc  caataatcg  aaactcctg  aaaaacaca  2040
taccgcggc  gagattgac  catttgtca  cctggtgcg  aagaacagg  agcccagat  2100
cttagatta  ctctccgac  tctgtgtct  catgaacaa  tcaattcca  tgacccagg  2160
actgatatg  aaagctgtg  tgaacccca  caacgctga  atcctgatt  agaccaaat  2220
ggttctttc  cgttttgaa  ttgaaggtg  ctcttccac  ggagagaat  ctctggagg  2280
aggagaaga  gaggaagag  tgtggctgt  ttggaggga  agcaacaaa  agattcgca  2340
caagagtgt  agggaattg  ctcaggatg  taaagaagg  cagaaggag  accgagacg  2400
tctcagcta  tacagatat  agctgaacc  ctttgcgag  atgtgtctg  accgccaat  2460
cctggccat  aacgaaatc  caggccagc  ggatgtcga  ctcattctc  gctgcatgt  2520
tgacgagaa  ctgccctat  acctcaggg  gtccttctg  cgcctcatg  ttcacatgc  2580
tgtggaccg  gatccccag  aacaagtca  ccccgtgaa  tatgcccgc  tctggtcgg  2640
gattccctc  gagatcgcc  ttgacgact  tgatagtag  ggagcttcc  aagatgaaa  2700
taaggagag  tttgctcag  ccatggagt  tgtggagga  tatttaaga  atgtggttt  2760
tcagaggtt  cctttctct  ataaagaga  gaataagct  acgtttgag  ttgtaaatt  2820
agctaggaa  ctcatatac  ttggtttct  caacttctc  gaccttctc  gattaacta  2880
gatccttct  gccatattg  actgtgtac  tgtgacaac  atcttcccc  ttagcaaga  2940
ggcgaaagg  gaagagaat  aaggcagta  cgtgatgag  tctattcat  gcgtgggag  3000
gctgatgac  caggtggtg  tccggggag  aggcttttt  cccatgact  ccatggctg  3060
tgcccctga  ggcaatgtg  agcaggcag  gcctgagaa  gaggacatc  tggtcatgg  3120
caccaagct  aagatcatt  agatactcc  gtttatttt  aatgtgagg  tggattata  3180
gatctcctg  ctcctgtgt  tatttaagc  agagtttga  gaaagcaat  cccagactt  3240
agaaacatc  tccggaaac  gcagccaag  agggccaag  aatgtacca  gtgctcttg  3300
ctttgaaca  attgaagaa  aagcagaag  catctttgg  ggaagtgag  agaacaccc  3360
actggactt  gatgaccac  gcggcagaa  ctttctccg  gtcctgctc  acttgacga  3420
gcatgacta  ccacccctg  tgtcagggg  cctgcagct  ctcttccgg  acttcagcc  3480
gaggcagga  gtgctccag  ccttcaaac  ggttcaact  ctggttacc  gccaagatg  3540
ggacaacta  aaacagatc  aacaagact  ggatcaact  aggtccatc  tggaaaagt  3600
agagctttg  gtgtacaaa  ggcagggcc  cgatgagac  atggatggt  catctggag  3660
aaatgaaca  aagaaaacg  aggagggaa  taacaagcc  caaaagcat  aaagcacca  3720
cagctacaa  tacagagtg  tcaaagaga  tttgattcg  cttagcaaa  tctgtgttc  3780
agagagtgc  tcagtgaga  agagcagga  gcagcaaca  cgtctgctc  ggaacatgg  3840
cgcgcacgc  gtggtgctg  agctgctgc  gattcccta  gagaaggcc  aagatacca  3900
gatgcaaga  ataatgagg  tggctcatg  atttttgca  aatttctgc  caggcaacc  3960
gcagaatca  gctttgcta  ataaacaca  aaacctgtt  ctcaaccca  ggatcctgg  4020
ggcagtaac  atgcagcac  tcttcatga  caatttcca  ctttgcagt  agatcaacg  4080
gagagttgt  cagcacttc  ttcactgca  agagactca  ggtcggaat  tccagtata  4140
aaagttctt  cagacaatt  tcaaggcag  agggaaatt  attaaaaaa  gccaagaca  4200
ggttatggc  gagctggtc  attcgggag  ggatgtcct  gtgttctac  acgacagag  4260
ctctttcca  actctgatc  agatgatgc  gtcagaacg  gatcggatg  atgagaaca  4320
ccctctcat  taccacatc  acttggtcg  gctcctggc  gtgtgcacg  agggtaaga  4380
tgtctacac  gagatcaag  gcaactccc  gctcccgct  gatgacatc  ttcgcgtgg  4440
gacccacga  gactgcatc  ctgaggtta  aattgcata  attaacttc  tgaatcact  4500
ctatgtgga  acagaggtg  aaatgaagg  gatttatac  agcaatcac  tgtggaaat  4560
gtttgagaa  ttccttgta  acatctgca  ggcctgtaa  aacactagt  acaggaaac  4620
tgcagactc  attttggag  agtatgtca  cgaaatcgt  atgagtatt  ttactactt  4680
cttcagctc  cccttctca  accagagta  gactttgca  actcgccag  ctgtctttg  4740
gcaactgct  caaggcgtg  tcagggttt  ccactgcaa  tggttaatg  caagccaaa  4800
agcctccgt  gagagctgt  ttcgggtgc  gtctgatgt  gccaagagc  gggccattg  4860
cattcccgt  gacctggac  gccaagtca  caacctctt  ctcaagtcc  acagcattg  4920
gcagaaaac  gccatgaac  ggcggctct  agcccgcaa  gccgcacgc  gggactctg  4980
tctggcagc  tccagagac  accggaata  cattgagag  ttgcaggac  tcgtctccg  5040
gctggagga  cgtctcagg  ccctggtgc  ggcagagtt  tctgtgctc  tggatgttc  5100
ccacagacc  gagctgctt  tcccagaga  cacagacgc  agaaggaaa  gtgaaagtg  5160
cggtttcat  tgcaagtta  taaagcata  aaaacagct  ctagaagaa  atgaagaga  5220
gctctgcat  aaggtccta  agaccctga  ggaaatgat  accaaagat  gaggctatg  5280
agaaaaggg  gaggcgctc  ggcaagttc  ggtcaaccg  tactatgga  acgtcagac  5340
ttcgggacg  agagagagc  ttaccagct  tggcaatgg  ccactgtca  caggaggac  5400
cggcaagcc  gggggagga  ggggaggtt  cggatccag  tctatgagc  ggggtgaga  5460
gagtctggc  gaggttcag  gtcaccttg  caaggaggg  gcttccaat  tagttatcg  5520
cctcatcat  aacgcatcc  gtgaccgag  gttccatga  agcattctc  tggccattg  5580
ccttctgga  ggaggcaac  ccaccatcc  gcactcctt  ttctgtcgc  tgacagaag  5640
taagaagtc  gagaaattc  ttaaggtgt  ttatgaccg  atgaaggtg  cccagcaag  5700
aatcaaagc  acagtgaca  tgaacacca  tgacttggg  aataaaaag  aagacgatg  5760
ggtagacag  gatgcccca  cacggaaaa  agctaaaga  cccacaaca  agataacag  5820
agaggtccg  gatcagctc  tggaggcct  cgctgccac  aggaaagcc  tcaccactt  5880
caggaggga  gctgatccc  acgaccact  ccagcctgg  gagggcacc  aggccactg  5940
cgacaaggc  aaggacgac  tggagatga  cgcggtcat  accatcatg  agcccatcc  6000
ccgcttcct  cagctcctg  gtgaaaacc  caaccgaga  ctgcagaac  tcctccgtt  6060
ccaaaataa  aagaccaac  acaatttgg  atgtgagac  ctgcagttt  tggactgta  6120
ttgtggaag  acaactgga  gccttggtc  tctgggctt  tatataaat  aaaagaacg  6180
agcgcttat  aaccaaacc  tggaaagtc  gaccgaata  tgtcaagga  cttgccatg  6240
gaaccagaa  tgcatagcc  cccatgaat  caatggcat  gacatcatc  cagccctga  6300
cctcaatga  atcaatcct  tgggaaaga  gaggatgga  cttgtgtta  aactgaaga  6360
caatgcctc  aagttgctc  tggccatca  ggaaagcag  cacgacagt  aaaacgcag  6420
gaggatact  tataacatg  ggcccaagg  actggtgga  gtgatcaag  aagcctaca  6480
gcaaggtga  gtggaattt  aggatggag  aaacggtga  gatggggcg  cgtccccca  6540
gaacgtggg  cacaacatc  acatattag  ccatcagtt  gctcggcat  acaaagaac  6600
tcagagcat  ctgaaacct  gtggccaag  ggacggaga  gaagccctg  agttttatg  6660
caagcacac  gcgcagata  agattgtca  attagaccg  acaatggaa  agatagtct  6720
tcccgtgcc  agcatatgt  aattcctaa  caaggagtc  aaactacga  tttactata  6780
tacagagag  gacgaacaa  gcagcaaaa  caatgattt  tttctgcgg  ctgaagacc  6840
cttcaatga  atgaattgg  agaagaaac  gagagccca  cccgtgttg  actggtgtg  6900
ccgcaacat  tctttctgg  gcagcattt  gtttaacct  gccgtcctg  tgaacctgc  6960
ggtggcgtt  ttctacccg  ttaagggag  ccgaggagg  accctggag  cccactggt  7020
gggactcct  tggacagcc  tgctcatct  tctggccat  gtcattgcc  tccccaagc  7080
ccatggcat  cgggcctta  ttgcctcca  aattctacg  ctgatattt  cagtcgggt  7140
acaacccac  ttgtttctt  tgggcgctt  caatgtatg  aataaaatc  tctttctaa  7200
gagctttgt  ggcaactgt  ggacattca  aagaggcta  cgagccatg  ttctggatg  7260
tgagttcct  tatcatttg  tgtatctgg  gatctgtgc  atggggctc  ttgtccatg  7320
attcttcta  agtctgctg  tttttgatt  agtgtacag  gaagagact  tgcttaatg  7380
cattaaaag  gtcactcgc  atggacggt  catcatcct  acagcagtt  tggctctga  7440
cctcgttta  ctgttctca  tagtgggct  tcttttctt  aaggatgac  ttatcttgg  7500
agtagatag  ctgcccaat  aaacagctg  tccagaaac  ggcgagagt  tggcaagcg  7560
gttcctgtt  tccgatgtg  gtagggtgg  gagtgggga  aactgctcc  ctcctgcac  7620
cagagaaga  ctggtccct  cagaagaga  ggaacagga  aaagagcac  catgtgaga  7680
gctgctgat  tgcattgtc  ccgtgctga  tcacgggct  cggagcggg  gtggagtag  7740
agatgtact  aggaaaccg  ccaaagagg  acccctgtt  gctgctaga  ttatttatg  7800
cctcttgtt  ttcttcatg  tcatcatca  tgttcttaa  ctgattttt  gggttatca  7860
tgacacttt  gctgacctg  ggagtgaga  gcagaagaa  gaagagatc  tgaagacca  7920
gtgctttat  tgtggcttg  aaagagaca  gtttgacaa  aagactgtc  cctttgaag  7980
gcacatcaa  gaagaacac  acatgtggc  ctatctgtg  ttcatcgtc  tggtgaaag  8040
aaaggactc  accgaatat  ctgggcctg  gagttacgt  gcagaaatg  tcaaggaaa  8100
aaaccttga  tggttcccc  ggatgagag  catgtcatt  gtcagcagt  attctgaag  8160
agaacagaa  gagctgaga  acctgcagg  gaagctgga  tccaccatg  aacttgtca  8220
gaacctttc  ggccagctg  cggaattaa  ggatcagat  acagaacaa  ggaagcaga  8280
acaaagaat  ggtcttcta  gacatcctc  tcacatgaa  gtcaaccca  aacaaccag  8340
ataagcaaa  gaaagaaag  aattgtatt  accttttat  attattatt  gtgtgggta  8400
ggctaatga  ttctgattc  cccacgaag  ttacattta  gctgaatac  tttgtaaat  8460
ctcagtttt  tactgtatg  atatgattg  tactctaaa  gtttggata  atgtattgt  8520
attagaatt  ttggcatga  gacatttca  ttgtgccaa  aatattaaa  atgcctttt  8580
tggaaggac  aacagaaag  acctgattt  cacttgaac  agattatag  tttaaaagt  8640
tatgacatg  attttgtat  taaaactag  atagccagt  tttatgttt  ttataaaac  8700
gtgcaatac  aattatgca  tcacaatac  tttgtagct  ccgagtgtc  taaagggag  8760
gcacttctt  gaagctggt  tgttaatac  atgtaataa  tggttaact  tcaaatgat  8820
ctgctgcca  aattatatt  atagtgagt  tcaggcccc  gggcatttt  taccatgta  8880
ttatcctct  gtgatgctg  ttctcgtta  tggcagtag  gcctccgtc  cctagtgat  8940
atgctccaa  tctatgaac  gttaaatca  cattcattt  aagaaaagc  actttagtt  9000
caaagatac  tttaagctt  taaattgat  atttaaact  tttctttaa  taagagagc  9060
aaattagag  ctcatactt  agcttgtga  gaagataat  aatttttta  agggaactt  9120
ctatgcaat  ttcaggata  atcgatact  ctggccaat  agtgtcatc  cctgggtaa  9180
ttttgatgt  gcattataa  gacatgcat  attgatggt  tctagatta  ctagtccaa  9240
caatagagt  tattttttc  tcatctgaa  caacatgct  cagtagcta  gaagtatta  9300
aactatata  atccatata  agatgaaat  tgaactatc  cattagaag  catagttga  9360
cacagacat  ttattcttc  gaaagagcc  cattttggt  ttatttctt  tcacatgat  9420
tcttttctt  atggatgaa  aatatgaaa  gaaatcttt  atatctgtt  cctagtttt  9480
tacatggat  tcattttac  agagaatct  tctgcta  9517



<210> 2642
<211> 2758
<212> PRT
<213> Homo sapiens
<308> Q14643
<400> 2642

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
  1               5                  10                  15
Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
             20                  25                  30
Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn 
         35                  40                  45
Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
     50                  55                  60
Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
 65                  70                  75                  80
Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                 85                  90                  95
Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
             100                105                110
Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
         115                120                125
Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
     130                135                140
Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
 145                150                155                160
Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                 165                170                175
Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
             180                185                190
Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
         195                200                205
Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
     210                215                220
Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
 225                230                235                240
Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                 245                250                255
Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
             260                265                270
Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
         275                280                285
His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
     290                295                300
Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
 305                310                315                320
Asp Phe Glu Glu Glu Cys Leu Glu Phe Gln Pro Ser Val Asp Pro Asp 
                 325                330                335
Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met Val 
             340                345                350
Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile Phe 
         355                360                365
Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro Arg 
     370                375                380
Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val His 
 385                390                395                400
Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met Leu 
                 405                410                415
Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala Ile 
             420                425                430
Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn Asp 
         435                440                445
Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly Thr 
     450                455                460
Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp Leu 
 465                470                475                480
Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu Glu 
                 485                490                495
Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu 
             500                505                510
Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe Thr 
         515                520                525
Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp Gln 
     530                535                540
Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val Leu 
 545                550                555                560
Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala Lys 
                 565                570                575
Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala Glu 
             580                585                590
Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
         595                600                605
His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg Lys 
     610                615                620
Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
 625                630                635                640
Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala Val 
                 645                650                655
Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val Leu 
             660                665                670
Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala Leu 
         675                680                685
Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp Ser 
     690                695                700
Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp Ala 
 705                710                715                720
Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg Tyr 
                 725                730                735
Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala 
             740                745                750
Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg Cys 
         755                760                765
Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys Arg 
     770                775                780
Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val Thr 
 785                790                795                800
Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile Ala 
                 805                810                815
Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys Glu 
             820                825                830
Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp Val 
         835                840                845
Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu Thr 
     850                855                860
Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe Tyr 
 865                870                875                880
Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile Leu 
                 885                890                895
Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala Lys 
             900                905                910
Gly Glu Glu Asn Lys Gly Asn Asn Asp Val Glu Lys Leu Lys Ser Ser 
         915                920                925
Asn Val Met Arg Ser Ile His Gly Val Gly Glu Leu Met Thr Gln Val 
     930                935                940
Val Leu Arg Gly Gly Gly Phe Leu Pro Met Thr Pro Met Ala Ala Ala 
 945                950                955                960
Pro Glu Gly Asn Val Lys Gln Ala Glu Pro Glu Lys Glu Asp Ile Met 
                 965                970                975
Val Met Asp Thr Lys Leu Lys Ile Ile Glu Ile Leu Gln Phe Ile Leu 
             980                985                990
Asn Val Arg Leu Asp Tyr Arg Ile Ser Cys Leu Leu Cys Ile Phe Lys 
         995                1000                1005
Arg Glu Phe Asp Glu Ser Asn Ser Gln Thr Ser Glu Thr Ser Ser Gly 
     1010                1015                1020
Asn Ser Ser Gln Glu Gly Pro Ser Asn Val Pro Gly Ala Leu Asp Phe 
 1025                1030                1035                1040
Glu His Ile Glu Glu Gln Ala Glu Gly Ile Phe Gly Gly Ser Glu Glu 
                 1045                1050                1055
Asn Thr Pro Leu Asp Leu Asp Asp His Gly Gly Arg Thr Phe Leu Arg 
             1060                1065                1070
Val Leu Leu His Leu Thr Met His Asp Tyr Pro Pro Leu Val Ser Gly 
         1075                1080                1085
Ala Leu Gln Leu Leu Phe Arg His Phe Ser Gln Arg Gln Glu Val Leu 
     1090                1095                1100
Gln Ala Phe Lys Gln Val Gln Leu Leu Val Thr Ser Gln Asp Val Asp 
 1105                1110                1115                1120
Asn Tyr Lys Gln Ile Lys Gln Asp Leu Asp Gln Leu Arg Ser Ile Val 
                 1125                1130                1135
Glu Lys Ser Glu Leu Trp Val Tyr Lys Gly Gln Gly Pro Asp Glu Thr 
             1140                1145                1150
Met Asp Gly Ala Ser Gly Glu Asn Glu His Lys Lys Thr Glu Glu Gly 
         1155                1160                1165
Asn Asn Lys Pro Gln Lys His Glu Ser Thr Ser Ser Tyr Asn Tyr Arg 
     1170                1175                1180
Val Val Lys Glu Ile Leu Ile Arg Leu Ser Lys Leu Cys Val Gln Glu 
 1185                1190                1195                1200
Ser Ala Ser Val Arg Lys Ser Arg Lys Gln Gln Gln Arg Leu Leu Arg 
                 1205                1210                1215
Asn Met Gly Ala His Ala Val Val Leu Glu Leu Leu Gln Ile Pro Tyr 
             1220                1225                1230
Glu Lys Ala Glu Asp Thr Lys Met Gln Glu Ile Met Arg Leu Ala His 
         1235                1240                1245
Glu Phe Leu Gln Asn Phe Cys Ala Gly Asn Gln Gln Asn Gln Ala Leu 
     1250                1255                1260
Leu His Lys His Ile Asn Leu Phe Leu Asn Pro Gly Ile Leu Glu Ala 
 1265                1270                1275                1280
Val Thr Met Gln His Ile Phe Met Asn Asn Phe Gln Leu Cys Ser Glu 
                 1285                1290                1295
Ile Asn Glu Arg Val Val Gln His Phe Val His Cys Ile Glu Thr His 
             1300                1305                1310
Gly Arg Asn Val Gln Tyr Ile Lys Phe Leu Gln Thr Ile Val Lys Ala 
         1315                1320                1325
Glu Gly Lys Phe Ile Lys Lys Cys Gln Asp Met Val Met Ala Glu Leu 
     1330                1335                1340
Val Asn Ser Gly Glu Asp Val Leu Val Phe Tyr Asn Asp Arg Ala Ser 
 1345                1350                1355                1360
Phe Gln Thr Leu Ile Gln Met Met Arg Ser Glu Arg Asp Arg Met Asp 
                 1365                1370                1375
Glu Asn Ser Pro Leu Met Tyr His Ile His Leu Val Glu Leu Leu Ala 
             1380                1385                1390
Val Cys Thr Glu Gly Lys Asn Val Tyr Thr Glu Ile Lys Cys Asn Ser 
         1395                1400                1405
Leu Leu Pro Leu Asp Asp Ile Val Arg Val Val Thr His Glu Asp Cys 
     1410                1415                1420
Ile Pro Glu Val Lys Ile Ala Tyr Ile Asn Phe Leu Asn His Cys Tyr 
 1425                1430                1435                1440
Val Asp Thr Glu Val Glu Met Lys Glu Ile Tyr Thr Ser Asn His Met 
                 1445                1450                1455
Trp Lys Leu Phe Glu Asn Phe Leu Val Asp Ile Cys Arg Ala Cys Asn 
             1460                1465                1470
Asn Thr Ser Asp Arg Lys His Ala Asp Ser Ile Leu Glu Lys Tyr Val 
         1475                1480                1485
Thr Glu Ile Val Met Ser Ile Val Thr Thr Phe Phe Ser Ser Pro Phe 
     1490                1495                1500
Ser Asp Gln Ser Thr Thr Leu Gln Thr Arg Gln Pro Val Phe Val Gln 
 1505                1510                1515                1520
Leu Leu Gln Gly Val Phe Arg Val Tyr His Cys Asn Trp Leu Met Pro 
                 1525                1530                1535
Ser Gln Lys Ala Ser Val Glu Ser Cys Ile Arg Val Leu Ser Asp Val 
             1540                1545                1550
Ala Lys Ser Arg Ala Ile Ala Ile Pro Val Asp Leu Asp Ser Gln Val 
         1555                1560                1565
Asn Asn Leu Phe Leu Lys Ser His Ser Ile Val Gln Lys Thr Ala Met 
     1570                1575                1580
Asn Trp Arg Leu Ser Ala Arg Asn Ala Ala Arg Arg Asp Ser Val Leu 
 1585                1590                1595                1600
Ala Ala Ser Arg Asp Tyr Arg Asn Ile Ile Glu Arg Leu Gln Asp Ile 
                 1605                1610                1615
Val Ser Ala Leu Glu Asp Arg Leu Arg Pro Leu Val Gln Ala Glu Leu 
             1620                1625                1630
Ser Val Leu Val Asp Val Leu His Arg Pro Glu Leu Leu Phe Pro Glu 
         1635                1640                1645
Asn Thr Asp Ala Arg Arg Lys Cys Glu Ser Gly Gly Phe Ile Cys Lys 
     1650                1655                1660
Leu Ile Lys His Thr Lys Gln Leu Leu Glu Glu Asn Glu Glu Lys Leu 
 1665                1670                1675                1680
Cys Ile Lys Val Leu Gln Thr Leu Arg Glu Met Met Thr Lys Asp Arg 
                 1685                1690                1695
Gly Tyr Gly Glu Lys Leu Ile Ser Ile Asp Glu Leu Asp Asn Ala Glu 
             1700                1705                1710
Leu Pro Pro Ala Pro Asp Ser Glu Asn Ser Thr Glu Glu Leu Glu Pro 
         1715                1720                1725
Ser Pro Pro Leu Arg Gln Leu Glu Asp His Lys Arg Gly Glu Ala Leu 
     1730                1735                1740
Arg Gln Val Leu Val Asn Arg Tyr Tyr Gly Asn Val Arg Pro Ser Gly 
 1745                1750                1755                1760
Arg Arg Glu Ser Leu Thr Ser Phe Gly Asn Gly Pro Leu Ser Ala Gly 
                 1765                1770                1775
Gly Pro Gly Lys Pro Gly Gly Gly Gly Gly Gly Ser Gly Ser Ser Ser 
             1780                1785                1790
Met Ser Arg Gly Glu Met Ser Leu Ala Glu Val Gln Cys His Leu Asp 
         1795                1800                1805
Lys Glu Gly Ala Ser Asn Leu Val Ile Asp Leu Ile Met Asn Ala Ser 
     1810                1815                1820
Ser Asp Arg Val Phe His Glu Ser Ile Leu Leu Ala Ile Ala Leu Leu 
 1825                1830                1835                1840
Glu Gly Gly Asn Thr Thr Ile Gln His Ser Phe Phe Cys Arg Leu Thr 
                 1845                1850                1855
Glu Asp Lys Lys Ser Glu Lys Phe Phe Lys Val Phe Tyr Asp Arg Met 
             1860                1865                1870
Lys Val Ala Gln Gln Glu Ile Lys Ala Thr Val Thr Val Asn Thr Ser 
         1875                1880                1885
Asp Leu Gly Asn Lys Lys Lys Asp Asp Glu Val Asp Arg Asp Ala Pro 
     1890                1895                1900
Ser Arg Lys Lys Ala Lys Glu Pro Thr Thr Gln Ile Thr Glu Glu Val 
 1905                1910                1915                1920
Arg Asp Gln Leu Leu Glu Ala Ser Ala Ala Thr Arg Lys Ala Phe Thr 
                 1925                1930                1935
Thr Phe Arg Arg Glu Ala Asp Pro Asp Asp His Tyr Gln Pro Gly Glu 
             1940                1945                1950
Gly Thr Gln Ala Thr Ala Asp Lys Ala Lys Asp Asp Leu Glu Met Ser 
         1955                1960                1965
Ala Val Ile Thr Ile Met Gln Pro Ile Leu Arg Phe Leu Gln Leu Leu 
     1970                1975                1980
Cys Glu Asn His Asn Arg Asp Leu Gln Asn Phe Leu Arg Cys Gln Asn 
 1985                1990                1995                2000
Asn Lys Thr Asn Tyr Asn Leu Val Cys Glu Thr Leu Gln Phe Leu Asp 
                 2005                2010                2015
Cys Ile Cys Gly Ser Thr Thr Gly Gly Leu Gly Leu Leu Gly Leu Tyr 
             2020                2025                2030
Ile Asn Glu Lys Asn Val Ala Leu Ile Asn Gln Thr Leu Glu Ser Leu 
         2035                2040                2045
Thr Glu Tyr Cys Gln Gly Pro Cys His Glu Asn Gln Asn Cys Ile Ala 
     2050                2055                2060
Thr His Glu Ser Asn Gly Ile Asp Ile Ile Thr Ala Leu Ile Leu Asn 
 2065                2070                2075                2080
Asp Ile Asn Pro Leu Gly Lys Lys Arg Met Asp Leu Val Leu Glu Leu 
                 2085                2090                2095
Lys Asn Asn Ala Ser Lys Leu Leu Leu Ala Ile Met Glu Ser Arg His 
             2100                2105                2110
Asp Ser Glu Asn Ala Glu Arg Ile Leu Tyr Asn Met Arg Pro Lys Glu 
         2115                2120                2125
Leu Val Glu Val Ile Lys Lys Ala Tyr Met Gln Gly Glu Val Glu Phe 
     2130                2135                2140
Glu Asp Gly Glu Asn Gly Glu Asp Gly Ala Ala Ser Pro Arg Asn Val 
 2145                2150                2155                2160
Gly His Asn Ile Tyr Ile Leu Ala His Gln Leu Ala Arg His Asn Lys 
                 2165                2170                2175
Glu Leu Gln Ser Met Leu Lys Pro Gly Gly Gln Val Asp Gly Asp Glu 
             2180                2185                2190
Ala Leu Glu Phe Tyr Ala Lys His Thr Ala Gln Ile Glu Ile Val Arg 
         2195                2200                2205
Leu Asp Arg Thr Met Glu Gln Ile Val Phe Pro Val Pro Ser Ile Cys 
     2210                2215                2220
Glu Phe Leu Thr Lys Glu Ser Lys Leu Arg Ile Tyr Tyr Thr Thr Glu 
 2225                2230                2235                2240
Arg Asp Glu Gln Gly Ser Lys Ile Asn Asp Phe Phe Leu Arg Ser Glu 
                 2245                2250                2255
Asp Leu Phe Asn Glu Met Asn Trp Gln Lys Lys Leu Arg Ala Gln Pro 
             2260                2265                2270
Val Leu Tyr Trp Cys Ala Arg Asn Met Ser Phe Trp Ser Ser Ile Ser 
         2275                2280                2285
Phe Asn Leu Ala Val Leu Met Asn Leu Leu Val Ala Phe Phe Tyr Pro 
     2290                2295                2300
Phe Lys Gly Val Arg Gly Gly Thr Leu Glu Pro His Trp Ser Gly Leu 
 2305                2310                2315                2320
Leu Trp Thr Ala Met Leu Ile Ser Leu Ala Ile Val Ile Ala Leu Pro 
                 2325                2330                2335
Lys Pro His Gly Ile Arg Ala Leu Ile Ala Ser Thr Ile Leu Arg Leu 
             2340                2345                2350
Ile Phe Ser Val Gly Leu Gln Pro Thr Leu Phe Leu Leu Gly Ala Phe 
         2355                2360                2365
Asn Val Cys Asn Lys Ile Ile Phe Leu Met Ser Phe Val Gly Asn Cys 
     2370                2375                2380
Gly Thr Phe Thr Arg Gly Tyr Arg Ala Met Val Leu Asp Val Glu Phe 
 2385                2390                2395                2400
Leu Tyr His Leu Leu Tyr Leu Val Ile Cys Ala Met Gly Leu Phe Val 
                 2405                2410                2415
His Glu Phe Phe Tyr Ser Leu Leu Leu Phe Asp Leu Val Tyr Arg Glu 
             2420                2425                2430
Glu Thr Leu Leu Asn Val Ile Lys Ser Val Thr Arg Asn Gly Arg Ser 
         2435                2440                2445
Ile Ile Leu Thr Ala Val Leu Ala Leu Ile Leu Val Tyr Leu Phe Ser 
     2450                2455                2460
Ile Val Gly Tyr Leu Phe Phe Lys Asp Asp Phe Ile Leu Glu Val Asp 
 2465                2470                2475                2480
Arg Leu Pro Asn Glu Thr Ala Val Pro Glu Thr Gly Glu Ser Leu Ala 
                 2485                2490                2495
Ser Glu Phe Leu Phe Ser Asp Val Cys Arg Val Glu Ser Gly Glu Asn 
             2500                2505                2510
Cys Ser Ser Pro Ala Pro Arg Glu Glu Leu Val Pro Ala Glu Glu Thr 
         2515                2520                2525
Glu Gln Asp Lys Glu His Thr Cys Glu Thr Leu Leu Met Cys Ile Val 
     2530                2535                2540
Thr Val Leu Ser His Gly Leu Arg Ser Gly Gly Gly Val Gly Asp Val 
 2545                2550                2555                2560
Leu Arg Lys Pro Ser Lys Glu Glu Pro Leu Phe Ala Ala Arg Val Ile 
                 2565                2570                2575
Tyr Asp Leu Leu Phe Phe Phe Met Val Ile Ile Ile Val Leu Asn Leu 
             2580                2585                2590
Ile Phe Gly Val Ile Ile Asp Thr Phe Ala Asp Leu Arg Ser Glu Lys 
         2595                2600                2605
Gln Lys Lys Glu Glu Ile Leu Lys Thr Thr Cys Phe Ile Cys Gly Leu 
     2610                2615                2620
Glu Arg Asp Lys Phe Asp Asn Lys Thr Val Thr Phe Glu Glu His Ile 
 2625                2630                2635                2640
Lys Glu Glu His Asn Met Trp His Tyr Leu Cys Phe Ile Val Leu Val 
                 2645                2650                2655
Lys Val Lys Asp Ser Thr Glu Tyr Thr Gly Pro Glu Ser Tyr Val Ala 
             2660                2665                2670
Glu Met Ile Lys Glu Arg Asn Leu Asp Trp Phe Pro Arg Met Arg Ala 
         2675                2680                2685
Met Ser Leu Val Ser Ser Asp Ser Glu Gly Glu Gln Asn Glu Leu Arg 
     2690                2695                2700
Asn Leu Gln Glu Lys Leu Glu Ser Thr Met Lys Leu Val Thr Asn Leu 
 2705                2710                2715                2720
Ser Gly Gln Leu Ser Glu Leu Lys Asp Gln Met Thr Glu Gln Arg Lys 
                 2725                2730                2735
Gln Lys Gln Arg Ile Gly Leu Leu Gly His Pro Pro His Met Asn Val 
             2740                2745                2750
Asn Pro Gln Gln Pro Ala 
         2755



<210> 2643
<211> 619
<212> DNA
<213> Rattus norvegicus
<308> J05592
<400> 2643

gcggccatg  agcccgaca  cagtccacg  aagatccag  ttacggttc  gctgctgga  60
cctcacctg  acccggagg  agccgagca  attcggagg  gccgcccca  ccctgccac  120
cttgtgctg  ccagcgacc  gtcatcccc  gaagtagat  aagaccgga  ccccaaccc  180
cttctcaag  ccacactgt  aatgtctcc  cggcaacgg  agaagatga  aaggactac  240
cccaccatg  aagagctcc  gacaatggt  gaacatcac  tagggcaac  gaaacaagg  300
gaagaacct  agggagcca  tgagagcac  gggaaccag  agtcctgcc  acctgggat  360
ccagacaca  gctcagcgt  aaggccaga  acctcgggg  cagcacaaa  gcctgcaga  420
tccaaaccc  agactcagg  gcagcgtgg  gtggagccc  gcacagagg  cctttcagc  480
cacatgcta  cactggatt  ccaaggagc  agcttggtc  gacagaagt  gacatccgg  540
gatcgccag  gagtgtgga  gttcatgga  actggatgt  tcttaatct  ttgttttta  600
acgtgataa  tttggtgtt  619



<210> 2644
<211> 171
<212> PRT
<213> Rattus norvegicus
<308> P19103
<400> 2644

Met Glu Pro Asp Asn Ser Pro Arg Lys Ile Gln Phe Thr Val Pro Leu 
  1               5                  10                  15
Leu Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg 
             20                  25                  30
Arg Pro Thr Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro 
         35                  40                  45
Glu Val Asp Glu Asp Arg Ile Pro Asn Pro Leu Leu Lys Ser Thr Leu 
     50                  55                  60
Ser Met Ser Pro Arg Gln Arg Lys Lys Met Thr Arg Thr Thr Pro Thr 
 65                  70                  75                  80
Met Lys Glu Leu Gln Thr Met Val Glu His His Leu Gly Gln Gln Lys 
                 85                  90                  95
Gln Gly Glu Glu Pro Glu Gly Ala Thr Glu Ser Thr Gly Asn Gln Glu 
             100                105                110
Ser Cys Pro Pro Gly Ile Pro Asp Thr Gly Ser Ala Ser Arg Pro Asp 
         115                120                125
Thr Ser Gly Thr Ala Gln Lys Pro Ala Glu Ser Lys Pro Lys Thr Gln 
     130                135                140
Glu Gln Arg Gly Val Glu Pro Ser Thr Glu Asp Leu Ser Ala His Met 
 145                150                155                160
Leu Pro Leu Asp Ser Gln Gly Ala Ser Leu Val 
                 165                170



<210> 2645
<211> 662
<212> DNA
<213> Homo sapiens
<308> U48707
<400> 2645

ccccagcca  ggagcaaga  aacagcccc  gaaagatcc  gttcacggt  ccgctgctg  60
agccgcacc  tgaccccga  gcggcggag  agattcgga  gcgccgccc  acccctgcc  120
ccctcgtgc  gaccagtga  cagtcatcc  cagagatag  tgaagaccg  atccccaac  180
cacatctca  gtccacttt  gcaatgtcg  cacggcaac  gaagaagat  acaaggatc  240
cacccacaa  gaaagagct  cagatgatg  ttgaacatc  cctggggca  cagcagcaa  300
gagaggaac  tgagggggc  gctgagagc  caggaaccc  ggagtcccg  ccacctggg  360
tcccagaca  agaagtgga  tcaaggctg  gcacctctg  gacagcaaa  aaaactgca  420
aatgcatcc  taaaactca  gagagaggc  gtaaggaac  cagcacaaa  gaaccctca  480
cccatatac  accactgga  tccaaggga  ccaactcgg  ctgagagag  aggaggtat  540
ttgggatca  gactgcagt  tgggaatgc  tggacaccg  atttgtttc  tattccttc  600
cttttgggg  aaatctctt  tttttaaaa  gtgataaat  tggtgttag  tcaaaaaaa  660
aa  662



<210> 2646
<211> 171
<212> PRT
<213> Homo sapiens
<308> Q13522
<400> 2646

Met Glu Gln Asp Asn Ser Pro Arg Lys Ile Gln Phe Thr Val Pro Leu 
  1               5                  10                  15
Leu Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg 
             20                  25                  30
Arg Pro Thr Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro 
         35                  40                  45
Glu Ile Asp Glu Asp Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu 
     50                  55                  60
Ala Met Ser Pro Arg Gln Arg Lys Lys Met Thr Arg Ile Thr Pro Thr 
 65                  70                  75                  80
Met Lys Glu Leu Gln Met Met Val Glu His His Leu Gly Gln Gln Gln 
                 85                  90                  95
Gln Gly Glu Glu Pro Glu Gly Ala Ala Glu Ser Thr Gly Thr Gln Glu 
             100                105                110
Ser Arg Pro Pro Gly Ile Pro Asp Thr Glu Val Glu Ser Arg Leu Gly 
         115                120                125
Thr Ser Gly Thr Ala Lys Lys Thr Ala Glu Cys Ile Pro Lys Thr His 
     130                135                140
Glu Arg Gly Ser Lys Glu Pro Ser Thr Lys Glu Pro Ser Thr His Ile 
 145                150                155                160
Pro Pro Leu Asp Ser Lys Gly Ala Asn Ser Val 
                 165                170



<210> 2647
<211> 619
<212> DNA
<213> Rattus norvegicus
<308> J05592
<400> 2647

gcggccatg  agcccgaca  cagtccacg  aagatccag  ttacggttc  gctgctgga  60
cctcacctg  acccggagg  agccgagca  attcggagg  gccgcccca  ccctgccac  120
cttgtgctg  ccagcgacc  gtcatcccc  gaagtagat  aagaccgga  ccccaaccc  180
cttctcaag  ccacactgt  aatgtctcc  cggcaacgg  agaagatga  aaggactac  240
cccaccatg  aagagctcc  gacaatggt  gaacatcac  tagggcaac  gaaacaagg  300
gaagaacct  agggagcca  tgagagcac  gggaaccag  agtcctgcc  acctgggat  360
ccagacaca  gctcagcgt  aaggccaga  acctcgggg  cagcacaaa  gcctgcaga  420
tccaaaccc  agactcagg  gcagcgtgg  gtggagccc  gcacagagg  cctttcagc  480
cacatgcta  cactggatt  ccaaggagc  agcttggtc  gacagaagt  gacatccgg  540
gatcgccag  gagtgtgga  gttcatgga  actggatgt  tcttaatct  ttgttttta  600
acgtgataa  tttggtgtt  619



<210> 2648
<211> 171
<212> PRT
<213> Rattus norvegicus
<308> P19103
<400> 2648

Met Glu Pro Asp Asn Ser Pro Arg Lys Ile Gln Phe Thr Val Pro Leu 
  1               5                  10                  15
Leu Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg 
             20                  25                  30
Arg Pro Thr Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro 
         35                  40                  45
Glu Val Asp Glu Asp Arg Ile Pro Asn Pro Leu Leu Lys Ser Thr Leu 
     50                  55                  60
Ser Met Ser Pro Arg Gln Arg Lys Lys Met Thr Arg Thr Thr Pro Thr 
 65                  70                  75                  80
Met Lys Glu Leu Gln Thr Met Val Glu His His Leu Gly Gln Gln Lys 
                 85                  90                  95
Gln Gly Glu Glu Pro Glu Gly Ala Thr Glu Ser Thr Gly Asn Gln Glu 
             100                105                110
Ser Cys Pro Pro Gly Ile Pro Asp Thr Gly Ser Ala Ser Arg Pro Asp 
         115                120                125
Thr Ser Gly Thr Ala Gln Lys Pro Ala Glu Ser Lys Pro Lys Thr Gln 
     130                135                140
Glu Gln Arg Gly Val Glu Pro Ser Thr Glu Asp Leu Ser Ala His Met 
 145                150                155                160
Leu Pro Leu Asp Ser Gln Gly Ala Ser Leu Val 
                 165                170



<210> 2649
<211> 662
<212> DNA
<213> Homo sapiens
<308> U48707
<400> 2649

ccccagcca  ggagcaaga  aacagcccc  gaaagatcc  gttcacggt  ccgctgctg  60
agccgcacc  tgaccccga  gcggcggag  agattcgga  gcgccgccc  acccctgcc  120
ccctcgtgc  gaccagtga  cagtcatcc  cagagatag  tgaagaccg  atccccaac  180
cacatctca  gtccacttt  gcaatgtcg  cacggcaac  gaagaagat  acaaggatc  240
cacccacaa  gaaagagct  cagatgatg  ttgaacatc  cctggggca  cagcagcaa  300
gagaggaac  tgagggggc  gctgagagc  caggaaccc  ggagtcccg  ccacctggg  360
tcccagaca  agaagtgga  tcaaggctg  gcacctctg  gacagcaaa  aaaactgca  420
aatgcatcc  taaaactca  gagagaggc  gtaaggaac  cagcacaaa  gaaccctca  480
cccatatac  accactgga  tccaaggga  ccaactcgg  ctgagagag  aggaggtat  540
ttgggatca  gactgcagt  tgggaatgc  tggacaccg  atttgtttc  tattccttc  600
cttttgggg  aaatctctt  tttttaaaa  gtgataaat  tggtgttag  tcaaaaaaa  660
aa  662



<210> 2650
<211> 171
<212> PRT
<213> Homo sapiens
<308> Q13522
<400> 2650

Met Glu Gln Asp Asn Ser Pro Arg Lys Ile Gln Phe Thr Val Pro Leu 
  1               5                  10                  15
Leu Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg 
             20                  25                  30
Arg Pro Thr Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro 
         35                  40                  45
Glu Ile Asp Glu Asp Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu 
     50                  55                  60
Ala Met Ser Pro Arg Gln Arg Lys Lys Met Thr Arg Ile Thr Pro Thr 
 65                  70                  75                  80
Met Lys Glu Leu Gln Met Met Val Glu His His Leu Gly Gln Gln Gln 
                 85                  90                  95
Gln Gly Glu Glu Pro Glu Gly Ala Ala Glu Ser Thr Gly Thr Gln Glu 
             100                105                110
Ser Arg Pro Pro Gly Ile Pro Asp Thr Glu Val Glu Ser Arg Leu Gly 
         115                120                125
Thr Ser Gly Thr Ala Lys Lys Thr Ala Glu Cys Ile Pro Lys Thr His 
     130                135                140
Glu Arg Gly Ser Lys Glu Pro Ser Thr Lys Glu Pro Ser Thr His Ile 
 145                150                155                160
Pro Pro Leu Asp Ser Lys Gly Ala Asn Ser Val 
                 165                170



<210> 2651
<211> 619
<212> DNA
<213> Rattus norvegicus
<308> J05592
<400> 2651

gcggccatg  agcccgaca  cagtccacg  aagatccag  ttacggttc  gctgctgga  60
cctcacctg  acccggagg  agccgagca  attcggagg  gccgcccca  ccctgccac  120
cttgtgctg  ccagcgacc  gtcatcccc  gaagtagat  aagaccgga  ccccaaccc  180
cttctcaag  ccacactgt  aatgtctcc  cggcaacgg  agaagatga  aaggactac  240
cccaccatg  aagagctcc  gacaatggt  gaacatcac  tagggcaac  gaaacaagg  300
gaagaacct  agggagcca  tgagagcac  gggaaccag  agtcctgcc  acctgggat  360
ccagacaca  gctcagcgt  aaggccaga  acctcgggg  cagcacaaa  gcctgcaga  420
tccaaaccc  agactcagg  gcagcgtgg  gtggagccc  gcacagagg  cctttcagc  480
cacatgcta  cactggatt  ccaaggagc  agcttggtc  gacagaagt  gacatccgg  540
gatcgccag  gagtgtgga  gttcatgga  actggatgt  tcttaatct  ttgttttta  600
acgtgataa  tttggtgtt  619



<210> 2652
<211> 171
<212> PRT
<213> Rattus norvegicus
<308> P19103
<400> 2652

Met Glu Pro Asp Asn Ser Pro Arg Lys Ile Gln Phe Thr Val Pro Leu 
  1               5                  10                  15
Leu Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg 
             20                  25                  30
Arg Pro Thr Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro 
         35                  40                  45
Glu Val Asp Glu Asp Arg Ile Pro Asn Pro Leu Leu Lys Ser Thr Leu 
     50                  55                  60
Ser Met Ser Pro Arg Gln Arg Lys Lys Met Thr Arg Thr Thr Pro Thr 
 65                  70                  75                  80
Met Lys Glu Leu Gln Thr Met Val Glu His His Leu Gly Gln Gln Lys 
                 85                  90                  95
Gln Gly Glu Glu Pro Glu Gly Ala Thr Glu Ser Thr Gly Asn Gln Glu 
             100                105                110
Ser Cys Pro Pro Gly Ile Pro Asp Thr Gly Ser Ala Ser Arg Pro Asp 
         115                120                125
Thr Ser Gly Thr Ala Gln Lys Pro Ala Glu Ser Lys Pro Lys Thr Gln 
     130                135                140
Glu Gln Arg Gly Val Glu Pro Ser Thr Glu Asp Leu Ser Ala His Met 
 145                150                155                160
Leu Pro Leu Asp Ser Gln Gly Ala Ser Leu Val 
                 165                170



<210> 2653
<211> 662
<212> DNA
<213> Homo sapiens
<308> U48707
<400> 2653

ccccagcca  ggagcaaga  aacagcccc  gaaagatcc  gttcacggt  ccgctgctg  60
agccgcacc  tgaccccga  gcggcggag  agattcgga  gcgccgccc  acccctgcc  120
ccctcgtgc  gaccagtga  cagtcatcc  cagagatag  tgaagaccg  atccccaac  180
cacatctca  gtccacttt  gcaatgtcg  cacggcaac  gaagaagat  acaaggatc  240
cacccacaa  gaaagagct  cagatgatg  ttgaacatc  cctggggca  cagcagcaa  300
gagaggaac  tgagggggc  gctgagagc  caggaaccc  ggagtcccg  ccacctggg  360
tcccagaca  agaagtgga  tcaaggctg  gcacctctg  gacagcaaa  aaaactgca  420
aatgcatcc  taaaactca  gagagaggc  gtaaggaac  cagcacaaa  gaaccctca  480
cccatatac  accactgga  tccaaggga  ccaactcgg  ctgagagag  aggaggtat  540
ttgggatca  gactgcagt  tgggaatgc  tggacaccg  atttgtttc  tattccttc  600
cttttgggg  aaatctctt  tttttaaaa  gtgataaat  tggtgttag  tcaaaaaaa  660
aa  662



<210> 2654
<211> 171
<212> PRT
<213> Homo sapiens
<308> Q13522
<400> 2654

Met Glu Gln Asp Asn Ser Pro Arg Lys Ile Gln Phe Thr Val Pro Leu 
  1               5                  10                  15
Leu Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg 
             20                  25                  30
Arg Pro Thr Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro 
         35                  40                  45
Glu Ile Asp Glu Asp Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu 
     50                  55                  60
Ala Met Ser Pro Arg Gln Arg Lys Lys Met Thr Arg Ile Thr Pro Thr 
 65                  70                  75                  80
Met Lys Glu Leu Gln Met Met Val Glu His His Leu Gly Gln Gln Gln 
                 85                  90                  95
Gln Gly Glu Glu Pro Glu Gly Ala Ala Glu Ser Thr Gly Thr Gln Glu 
             100                105                110
Ser Arg Pro Pro Gly Ile Pro Asp Thr Glu Val Glu Ser Arg Leu Gly 
         115                120                125
Thr Ser Gly Thr Ala Lys Lys Thr Ala Glu Cys Ile Pro Lys Thr His 
     130                135                140
Glu Arg Gly Ser Lys Glu Pro Ser Thr Lys Glu Pro Ser Thr His Ile 
 145                150                155                160
Pro Pro Leu Asp Ser Lys Gly Ala Asn Ser Val 
                 165                170



<210> 2655
<211> 619
<212> DNA
<213> Rattus norvegicus
<308> J05592
<400> 2655

gcggccatg  agcccgaca  cagtccacg  aagatccag  ttacggttc  gctgctgga  60
cctcacctg  acccggagg  agccgagca  attcggagg  gccgcccca  ccctgccac  120
cttgtgctg  ccagcgacc  gtcatcccc  gaagtagat  aagaccgga  ccccaaccc  180
cttctcaag  ccacactgt  aatgtctcc  cggcaacgg  agaagatga  aaggactac  240
cccaccatg  aagagctcc  gacaatggt  gaacatcac  tagggcaac  gaaacaagg  300
gaagaacct  agggagcca  tgagagcac  gggaaccag  agtcctgcc  acctgggat  360
ccagacaca  gctcagcgt  aaggccaga  acctcgggg  cagcacaaa  gcctgcaga  420
tccaaaccc  agactcagg  gcagcgtgg  gtggagccc  gcacagagg  cctttcagc  480
cacatgcta  cactggatt  ccaaggagc  agcttggtc  gacagaagt  gacatccgg  540
gatcgccag  gagtgtgga  gttcatgga  actggatgt  tcttaatct  ttgttttta  600
acgtgataa  tttggtgtt  619



<210> 2656
<211> 171
<212> PRT
<213> Rattus norvegicus
<308> P19103
<400> 2656

Met Glu Pro Asp Asn Ser Pro Arg Lys Ile Gln Phe Thr Val Pro Leu 
  1               5                  10                  15
Leu Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg 
             20                  25                  30
Arg Pro Thr Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro 
         35                  40                  45
Glu Val Asp Glu Asp Arg Ile Pro Asn Pro Leu Leu Lys Ser Thr Leu 
     50                  55                  60
Ser Met Ser Pro Arg Gln Arg Lys Lys Met Thr Arg Thr Thr Pro Thr 
 65                  70                  75                  80
Met Lys Glu Leu Gln Thr Met Val Glu His His Leu Gly Gln Gln Lys 
                 85                  90                  95
Gln Gly Glu Glu Pro Glu Gly Ala Thr Glu Ser Thr Gly Asn Gln Glu 
             100                105                110
Ser Cys Pro Pro Gly Ile Pro Asp Thr Gly Ser Ala Ser Arg Pro Asp 
         115                120                125
Thr Ser Gly Thr Ala Gln Lys Pro Ala Glu Ser Lys Pro Lys Thr Gln 
     130                135                140
Glu Gln Arg Gly Val Glu Pro Ser Thr Glu Asp Leu Ser Ala His Met 
 145                150                155                160
Leu Pro Leu Asp Ser Gln Gly Ala Ser Leu Val 
                 165                170



<210> 2657
<211> 662
<212> DNA
<213> Homo sapiens
<308> U48707
<400> 2657

ccccagcca  ggagcaaga  aacagcccc  gaaagatcc  gttcacggt  ccgctgctg  60
agccgcacc  tgaccccga  gcggcggag  agattcgga  gcgccgccc  acccctgcc  120
ccctcgtgc  gaccagtga  cagtcatcc  cagagatag  tgaagaccg  atccccaac  180
cacatctca  gtccacttt  gcaatgtcg  cacggcaac  gaagaagat  acaaggatc  240
cacccacaa  gaaagagct  cagatgatg  ttgaacatc  cctggggca  cagcagcaa  300
gagaggaac  tgagggggc  gctgagagc  caggaaccc  ggagtcccg  ccacctggg  360
tcccagaca  agaagtgga  tcaaggctg  gcacctctg  gacagcaaa  aaaactgca  420
aatgcatcc  taaaactca  gagagaggc  gtaaggaac  cagcacaaa  gaaccctca  480
cccatatac  accactgga  tccaaggga  ccaactcgg  ctgagagag  aggaggtat  540
ttgggatca  gactgcagt  tgggaatgc  tggacaccg  atttgtttc  tattccttc  600
cttttgggg  aaatctctt  tttttaaaa  gtgataaat  tggtgttag  tcaaaaaaa  660
aa  662



<210> 2658
<211> 171
<212> PRT
<213> Homo sapiens
<308> Q13522
<400> 2658

Met Glu Gln Asp Asn Ser Pro Arg Lys Ile Gln Phe Thr Val Pro Leu 
  1               5                  10                  15
Leu Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg 
             20                  25                  30
Arg Pro Thr Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro 
         35                  40                  45
Glu Ile Asp Glu Asp Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu 
     50                  55                  60
Ala Met Ser Pro Arg Gln Arg Lys Lys Met Thr Arg Ile Thr Pro Thr 
 65                  70                  75                  80
Met Lys Glu Leu Gln Met Met Val Glu His His Leu Gly Gln Gln Gln 
                 85                  90                  95
Gln Gly Glu Glu Pro Glu Gly Ala Ala Glu Ser Thr Gly Thr Gln Glu 
             100                105                110
Ser Arg Pro Pro Gly Ile Pro Asp Thr Glu Val Glu Ser Arg Leu Gly 
         115                120                125
Thr Ser Gly Thr Ala Lys Lys Thr Ala Glu Cys Ile Pro Lys Thr His 
     130                135                140
Glu Arg Gly Ser Lys Glu Pro Ser Thr Lys Glu Pro Ser Thr His Ile 
 145                150                155                160
Pro Pro Leu Asp Ser Lys Gly Ala Asn Ser Val 
                 165                170



<210> 2659
<211> 17517
<212> DNA
<213> Rattus norvegicus
<308> J05677
<400> 2659

ggatcctgt  ccttctggc  ctccactta  atggatata  tcacagtga  ttaactttt  60
agaaaaaac  actaaaaaa  acccccaga  acacaaata  ttataaacc  tctgcttgc  120
gttttagtt  ctgagacag  gtttctttg  gtagcccac  ctgagctgg  actcactct  180
tagatcagg  tagtcttga  ctaagagat  tatctgcct  cctctgcct  agaagctct  240
tggttaaag  tatgcacca  caccaccta  ccacctggt  ttctttaaa  catggataa  300
taaataaaa  aataaaaat  aaaaataaa  atggatggt  atagctata  ataaaacgg  360
gagacttca  gcctgcctc  ctaaaaaaa  tccctaact  ttcatgtat  gaaaataga  420
ttcaacagt  tgctctctc  acataatac  ttttttctt  tctttctta  ctacaatta  480
tttaagtca  acatatgtg  ttgtatgct  tgtgtgtat  tgtgtgtgt  tatgtgtgt  540
cacacacgc  cgtgcatac  caccctaga  gtatagaat  ccctggagc  ggaataaag  600
ttgtttgtg  accactaga  gtagtttct  ggaatcgaa  tatggtcga  gggcaataa  660
tgttcttaa  cgctgagct  tatctccaa  cccaaatac  cttttcttc  tttgaccct  720
ggtgatagt  gccctcatc  ccgtctctg  gcatatccc  gtctctttt  cagtgctta  780
agtatattg  gttatggtt  tttgttctc  aaaacatat  ttatatata  atatatata  840
aatcgttat  ccgtcaaca  ctaactggc  cttgacata  ctgtcctct  gaaatgttt  900
ctgatctta  ttcctgttt  tgctcaaga  tggcgaagc  gatggcgca  tacggttaa  960
gaatccgga  gaccattag  gggcacact  atcccatgc  gttccgtcc  aaaggccca  1020
cagtttgga  ttccccaga  tcgctcctt  atttattct  cccatgatc  tttccaccc  1080
gaactccac  gtcccattt  aataatctt  cacacaaaa  actcaaacg  cgttacatc  1140
cttccctag  cacccaccc  ctctcccca  tttctgtta  tatttggga  ttaaagagt  1200
aactccacc  tcccacctg  tcatcttgc  cagttaatc  gcgcgatct  ggaggcggc  1260
aagaagaaa  gggaggtac  cattgatgg  ctgggtaac  cggactctg  ctcgcccct  1320
cttgattgc  ttttctaga  accctccca  actcctatt  gccacacac  ccttttccg  1380
ccaagatcc  aacaagctt  cctctccct  ggaaccagg  agaccagag  ggcatagga  1440
agagggcgg  gggcagctt  ttcacacct  cttcctcag  cctagtccc  cggcggcct  1500
gccgccgcc  gcgggtgct  ccaggggag  gaaacctcg  gcagcggca  cgggccgga  1560
agagggtca  caataactg  cgcacggga  ggtggggag  cagcggtag  cagggctgg  1620
aggaaggag  taaagagtc  ggattggtt  ccccggctc  cttgtcacc  aatctggga  1680
gggaggatt  gctgccctg  ctcgggacc  tgtggtccc  tcccccccc  gcccgcctc  1740
ggaacggcc  gagactggg  ccagccgga  gccccttct  gcacactcc  ggggcaagc  1800
cgagcgcac  ctccccttt  cttgctggc  ctccctctc  cctcgctct  tctctctag  1860
ccgtcctct  cttccctcg  tctccaccg  ctcccttcg  gtgctgtgc  tgctcccac  1920
tgctctgaa  cgctctccg  tctcggacg  tcccaattt  gcgctcctg  tcgacggcc  1980
aaccgtcgc  gcctccgca  gcagcgtgc  ctcggggtt  cggcttcaa  ccaccccag  2040
ttcctccct  gctacgact  gggcgccct  gacgttcga  cctcgccgc  gagcccgag  2100
atggcgagc  gaccatggt  acagcgctg  ccggtcgct  cactcgctg  ggccatgcc  2160
ggctcccga  gcgtccgtc  gcgcctaag  gcgctgctg  tgctgccgc  gcttctgct  2220
ctccggggc  gccacgcga  cgacctgac  gtggctgtg  tgctgccgc  gaccaacac  2280
tcgtacccg  ggtcctggg  gcgtgtagg  ccggccgtg  aactggctc  cgcgcgggt  2340
aaggctcgg  cggacttgc  gccgggttg  acggtccgc  tggtgctgg  cagcagtga  2400
aacgcggcg  gcgtctgct  ggacaccgc  gcaccgctg  ccgcggtgg  cctcaagtg  2460
gagcacagc  ccgcggtgt  cctgggccc  ggctgcgtc  actccgctg  cccggtggg  2520
cgcttcacc  cgcactggc  ggtgccgct  ctgaccgcc  gcgccccgg  tctgggcat  2580
ggggtcaag  atgagtatg  gctaaccac  cgcacagga  ccagccatg  caagctggg  2640
gatttcgtg  cggcgctgc  tcgacggct  ggctgggag  accaggcgc  ggtgctcta  2700
gcagatcgg  tgggcgacg  ccggccttg  ttcttcata  tggaggggc  gtacatgcg  2760
gtgcgtgaa  gcctcaaca  cacagtgaa  caccaggag  tcgtcgagg  cgacccgga  2820
cactacccc  agctactgc  ggccgtgcg  cgaaagggc  gaggtgagg  tggcacccg  2880
cggacagct  gctcgtgcg  cctgatctc  ggcctgtcc  cgggcctgg  attcctcct  2940
tgggggcca  gcttcctcc  cttagcgtc  tgctcaaca  gactttcct  cctcggagt  3000
tctagttcc  tctctccgc  ccgggtttg  attcctacc  tctcctcct  ccgtcctgt  3060
tcaagtgac  ttcctgctg  gaactttct  gatttaagc  cggaagggc  tagttctag  3120
gctactgct  cctcagctt  ctgactcct  tctccagtt  tcgctctac  ctaccacgg  3180
ctctctcct  cggttcctt  tattgctcc  acacaagct  tcaggctct  gggtccctt  3240
tcccgcaga  tcttcctgc  gtcttggtc  cccaccccc  cccacatcc  cacaccttg  3300
cccaccttc  cttccttcc  cccacccct  tctctcttc  tactctgca  accttctcc  3360
ttctttccc  ttcccttgc  aaggcccag  ctgagccag  agtcgctgt  ctttaaaaa  3420
tacaaactc  gaattccct  ccttttagt  ccctgcgtg  tcattcatg  ggtctctct  3480
tctctctct  tctctctct  tctctctgt  tctctctct  tgtgtctct  tctctgtgt  3540
tctctctct  tctctctct  tgtctctct  tctctctgt  tctgtctct  tctctgtgt  3600
tctctctct  tctctgtct  tctctctct  tctctgtct  tctgtctct  tctctcttc  3660
cgtctcttc  cttcttcct  cttttcctt  agttatcta  atctgcagt  ctccggatg  3720
cttcaggaa  ctgatgctt  tggccctga  cgctggcct  actggggag  actatgttt  3780
cttccacct  gatgtgttt  ggcaaagcc  taagagtgc  cagggcctt  ttccccaga  3840
accctggga  agaggagat  ggcaggaca  gagtgcccg  caggccttt  aggtgagtg  3900
tgaggtttg  agcccagga  tcttaagtt  ttgacatat  ctttctggg  actctgccc  3960
tgtgtatct  aaatgatta  agaaaacag  tttttgata  tcttgagtt  aaccatgaa  4020
ttcgtggga  ttaaggact  gaggctaaa  agattattt  atagccctg  gtaaaagaa  4080
attaaagac  cctggacta  ataatgttt  aatcctttt  ctcaaccac  ggaccatgt  4140
atgcaggac  catggatca  tttgatctt  gtcttattt  atatttatt  tttattttg  4200
tttttgctt  gtttttgtt  ttgttgttt  gttttgttt  gtttgggtc  gagtctctc  4260
atgtattac  ggttgtcct  gaacttatt  cacagatca  gctgggctc  aattcaaag  4320
ttctcttgc  tctgcctcc  gcatgctag  gttaaagac  tgtgctacc  cacccagct  4380
atcaacttg  tcccgacct  aacaggctg  tctgagagg  aggacccca  atgataggg  4440
caggataca  gaaggactg  agtcagctc  taccactcc  cctttcaat  attccttcc  4500
taggctgcc  aaattatta  ttacaaaga  cctgataat  ctgagtact  ggaattcct  4560
aagcagctg  aactcttgg  tgacaagaa  ttcaacttc  ccgtggagg  tggcctggt  4620
tgagggggt  ctaggctcc  ccagtgtgg  tctctagac  ctaattcat  gctttctgt  4680
agtctgtcc  actctctcg  gcattccag  atcacatct  cccttcttt  ttcctatta  4740
ttctgaatc  ctcctgatg  tgaaggggg  caatggcga  tttaaccct  gaacatgaa  4800
tcctcatca  ggaaaatgc  agtggcata  cctgcccta  ctttctctc  agcatgact  4860
ggtgtcaga  gaattgtag  tgcaaaagc  tcttttagg  agtcatatt  gtgtggact  4920
tgggtgtct  ctctatccc  tccaagctc  cactacccc  ccccagttc  ctgcccaca  4980
cgctacagt  tgtcactct  agcccttta  ctctgccct  tctgagctc  gcttgcttc  5040
acagaagaa  atcatccca  cctccttcc  cgacgggct  ctgctctat  tccaggcag  5100
gacagagac  ctggcacag  ggggaactg  cacagatgg  gagaacatc  ctcagcgga  5160
gtggaaccg  agcttccaa  gtcagggcc  agaattaac  ggaatgggc  gctttggga  5220
tggaggtga  agtgagccc  agatgtccc  gcaggagac  acaggaagc  tattaccca  5280
ctgggtacc  taagtttcc  aaaattctg  atgctgtct  ccattccca  agccagcac  5340
gctgccctt  tcactgttg  gcatatatc  atgttagtg  ctgcatctc  gtcgagggg  5400
gttggaggg  tgggatgat  taaggcatc  ctgaacctc  attatttca  aacacagcc  5460
tcctcccct  cggccctag  tgtgacagg  tacctgaaa  ttgatagaa  cggagatcg  5520
gacaccgat  tctctctct  ggatatgga  ccagagacg  gtgccttca  ggtaagttc  5580
cacataccc  aagaagaca  tgcctgcca  gaatggcct  tcatcctcc  aaccgcact  5640
caccccaca  ccctgccag  tatctgctt  ttctttgga  atctatgag  tactaatga  5700
gcaggctca  ctaactctt  agtctggga  cagccaaaa  gatgagatg  gtaaacttc  5760
tccctcaga  aaccccaag  ctgaagagg  aacatagag  ccttccctt  agttcctaa  5820
acaggtggg  ccccatcct  gcagagaca  ggactctgg  caagaagaa  gcatgtgtg  5880
ctctgtgta  atgtagcaa  gacaggaag  gacaggggt  aaaggcacc  agattcaga  5940
ctactagtg  aggcctcct  gaggagaca  attagggct  gaagtgtac  ctgaggaat  6000
atttatgcc  tccaatcaa  accaactcc  tgagtatag  gttggggtt  ccaatgtgg  6060
tccctatgg  tgcttctct  caaacctgt  agtgttcaa  tttttgccc  ttagtgccc  6120
ggccatggg  tggaagact  atggatagt  acagcagga  ccaagtgag  agtccatgg  6180
ccaaatgca  gtcctggaa  tagattggc  agagcagga  gcaggatgg  aggggggtc  6240
acaggcact  accactcct  ttctcactc  ccactcctg  tctccctca  gttgtcctg  6300
actataatg  tacttccca  gagctaatg  ctgtgtcag  acacaaatt  tactggcct  6360
tgggatatc  acctcctga  gtccctaaa  gtggctttg  caatgagga  ccagcctgc  6420
accaaggtg  ccgggccca  gcttccaga  tcctgtcgt  gagccactg  ctcctcccc  6480
ggggagtta  acagaggtt  ccttgctcc  gactttact  cccttcttt  atcatatca  6540
acgattctg  ctgactatt  gatgatttc  ccttcctat  gtctaaccc  ggtctctct  6600
ctacaactt  gactctccc  cagaccact  ttccacact  gaggttctg  ctttggtgg  6660
cagcctctc  ctgattagc  ttctgattg  gtctttctt  atatacagg  aagttaagg  6720
acaggggtg  taggtgagg  tggggagac  ggagcacag  gaagggagc  ggaggagag  6780
aggcctggg  gggagccta  cgcgggaaa  gaatgcgtc  ttcactccc  cagtgagga  6840
gcagaagct  cagatggag  caggaaggt  tggatcagt  atgttggtt  aggctaggt  6900
aaagccaca  cgtagctgg  aagtgactt  agagcagag  cgatgctgg  gtggatctg  6960
catcctttg  tgagggcag  tagaaagca  tagtttaaa  ccttcaggt  gctagacaa  7020
ggtggtaca  gcctttaat  ccagcactc  agaagcaga  gcaggtgaa  ctgagttca  7080
ggccagcct  gtctacaga  agcgttcca  gacagccag  gctacacag  gaaaccctg  7140
ctccaaaaa  caaactagc  aacaaacaa  cttcaagta  taacccaaa  gagttggtt  7200
tggataaca  atcgctgag  gctaggtgc  gaccctaga  cacccaccc  tcccctacc  7260
cacacccca  attctcacc  ctgtgcatg  ggaaatgaa  gtacagagg  gggataagg  7320
aacaggaaa  aggagggaa  agagcagtg  tgactgagc  tgtgcgcca  gcacttcca  7380
actcaggat  acactgcat  ctgtaataa  taagaatga  atggaaggg  ctggggatt  7440
agctcagtg  tagagcgct  acctaggaa  cgcaaggcc  tgggttcgg  ccccagctc  7500
ggaaaaaag  accaaaaaa  aaaaaaaaa  aaaaaaaaa  aatgaaatg  aagccgggt  7560
tgctacaca  aagctttat  cccagcact  gggtggtag  ggcaggtgg  tctctgtga  7620
ttcaaggcc  gcctgctgg  ctacatagg  acaacccag  ccacatagt  agatccctg  7680
ctcataaac  acaacaaca  caacaaaac  aaaaaaccc  gaggcctcc  gtctccaaa  7740
gaagaaact  aagtgactt  tcccctggg  taagatccc  tgtgagtta  aatttctca  7800
gccccaagc  ctcagctct  agaacagga  tccctcaag  atctcttag  atgtgggat  7860
tgctgggac  ctgaggggc  atggagcac  tgccagggg  aggggctca  gtgcaggct  7920
cacattcca  gaagatgca  ctggaaaag  agctggtct  agagttgtg  cgggtgcgc  7980
gggaggact  gcagcccag  agcctggag  ggcatcttc  gagcgctgg  agccggctg  8040
ccctgagtg  ggtgaggac  ccattgtct  tgtaggatg  gaatagctg  gtcccaagg  8100
ctgatgagt  agtagaagc  gcttctaga  gaggtgact  acctggacc  aggacttgg  8160
aggttaata  ggaaagatt  ctgtaggtc  gaggcaagc  tgtgctaca  aatgggacc  8220
cgtcttgta  aaccaaaac  aaacaaaag  ataggtcta  ccccagttc  gccttcact  8280
gcttaccct  acattgtct  agatgaggg  tatagttac  gcctctgta  caaggctct  8340
tcaaagctc  aaggaagat  gtctaagta  atacataaa  gagggtggg  gctagcatt  8400
gtgactcac  cctgcaatc  atcctagcc  gggagggtg  gtctggggc  ctgctacaa  8460
ttccagggc  gcctgagct  aagagtaag  ccctatctc  ggagggtga  acagataag  8520
gacagtgtg  ctgaaccta  aacttccag  atgcagaat  acctctggg  tggccaata  8580
atgactatt  tttctctct  tagcgaggc  ccaattatg  ctccctgct  accaccgag  8640
gccagttcc  agtctttgc  aagacagca  actataagg  aggtctggg  aaagattgc  8700
gatcttggg  ccctggtgg  gtgtggtct  aagaataag  gatggtagc  tgccaggga  8760
caggggtag  cccagggca  ggatgggct  ttagaagca  gtagagaac  gctgtcatg  8820
atgggtttc  gaagcagat  ggggtctcg  gccatctcc  gagtaataa  tctccattt  8880
ctgctcagg  caaccttgt  gctgtgaaa  gtgtgaacc  gaaacgcat  gagttgaca  8940
gaaaagtcc  gtttgaact  aaacatgta  ttaagggga  caaggtggt  gcttgggaa  9000
ggcttggtg  gtactccaa  agagtaagc  aactgatta  ggagggatc  atacagctg  9060
gatgggccc  tgagtcttg  gggtaggaa  gagatcggt  ataagatga  agatcactg  9120
gccctccag  ccccagatg  gttgtcctc  catgtacag  aaataaatg  ttagggagc  9180
aattccgag  aagaatggt  acaaacatg  gacttggtg  ggtttgaag  ctctgccag  9240
gccttgatg  tgccccaat  tgcagatgc  ggatgtgca  aatgagcac  tgacaagat  9300
tgtgggtgc  tgtaccgac  cccccaaca  ctgtatcct  acagagtac  gtccccgtg  9360
aagcctaca  gtgagtggg  caagaagaa  tgggacagt  aaaaagcct  ggttctagc  9420
ctggctctt  ccccattga  catgagccc  gataagccc  ctctttgtg  ccatgcttg  9480
ccctctctg  aaatgggag  tgggggctg  catggcact  cagtaaatc  aagtgtcca  9540
gcttacacc  gtagctccc  tgtaccctc  tcctactcc  aggggggtc  gactcttgc  9600
gccccagca  gacattcta  agaatgaga  tatcaccct  gactggatg  ttcggtact  9660
gctcaccaa  gacattgtc  aggtgagtc  agaggagat  actggatgc  aggcaagag  9720
tgggcatgg  tggaagtca  actcatgtc  aagccctct  gccttccta  atgttccag  9780
gaatgctct  tctacacaa  ggggccatt  gttcccatg  gaacctcaa  tcatccaac  9840
gtgtggtag  cgggcgctt  gtgttaaag  tcacagact  cggtcttga  agcttcaga  9900
acccggagc  agagcaagg  cacaccctc  ttgccagtg  gtctgactc  ttttttttt  9960
ttttaagat  tatttatta  atataagta  actgtagct  tcttcagac  caacagaag  10020
gggcatcaa  tctcattat  gatggttgt  agccaccat  tggttgctg  gatttgaac  10080
caggacctc  ggaagagca  tcggtgctc  taaccactg  gccatctct  cagccctgt  10140
agtctgact  ttgacccta  gatctctgc  gccagcaca  ctgagaagg  acactgaga  10200
ctagcctct  caagacttg  gtatatctc  catctccat  ctcaacctt  attggttaa  10260
aaggaagtc  gactaagtg  tcactggtt  tcagcactg  gctgtgtcc  caggagtcc  10320
agccaatgt  tttctttta  tgtagcatt  cctattaga  tgtaaaatc  cttatccct  10380
ctatgactc  tgacctctg  tccacagaa  aattgtgga  ggcacctga  ctcctgcga  10440
tggcttcgc  acctgcccg  ggctcccaa  ctggggatg  gtacagctt  ggtatcatc  10500
tgcaggaga  tgccctaag  agtggggtc  tctatgtgg  aggtttgga  ctcagccca  10560
aaggtgagg  tcacatggc  tatatccca  ctggtcttg  cgaatccac  tccagagaa  10620
gaacctctc  aaacacccc  actgttcct  ctggagtgg  gagtcagcc  ctcgctgtc  10680
tttgcgcca  ggctgccag  gaccagctc  cccctgtgc  ctggtctgg  ctcgcccca  10740
ctgcctgtc  cagccggtt  cccaactag  cttgctgct  ttcagcgca  cccccttcc  10800
cacagagat  attgagcgt  tgactcggg  tgagcagcc  ccattccga  cctccatgg  10860
tctgcagag  cacctggag  aactggggc  gctgatgca  cggtgctgg  cagaggacc  10920
acaggagcg  ccacccttt  agcagattc  cctggcgct  cgcaagttc  acaagttag  10980
ggtctctcc  cactacagg  actataaat  ccacactta  atttttttc  acagtggca  11040
cctactgca  ctcttcaca  cctcataga  gtctgcaca  ctgtatgat  tggttgtcc  11100
aacagctcc  accattcac  actccttcc  ctgccaaca  tgacatccc  caccctttc  11160
tgcccacag  cctgtactg  cccccagac  taagataaa  aagactata  gggccagat  11220
ctccaatcc  ttcccattt  ttcccatag  ctcagtcct  ctcaaaagc  cctacccca  11280
tccttgtgt  tcttttttc  agtatgccc  ctggctggt  ctctcagtc  tgtttctct  11340
ctgcctgtc  tcgtcctca  ctctccacc  ccttcaaac  catttgtga  caataagaa  11400
aaatatagt  tccagcatg  ggactggag  gatggctta  cggttaaga  cactgactg  11460
tcttccaga  gtcctgagt  caattccca  caaccacat  gtggctcct  accatctga  11520
tgccctctt  tggtgtgtc  gaagaccac  acagtgtgc  cacatacat  aaataaata  11580
ataaatctt  aaaaaaaaa  aaaaaggta  ccagctggg  atagaagca  gtggatatc  11640
atgggttca  ggccagctg  tcctttcac  taaaatacc  gataatgtg  acagatcca  11700
ctataacta  ttagagaga  cgtgtctct  agggtgggg  cgggcatgg  gagtgcctg  11760
gtgtgggca  tgccaggca  gaccagtca  ctcatttca  ctgcccccc  gtaccccac  11820
gccctcagg  agaacagca  caacatcct  gacaacctg  tgtcacgca  ggagcagta  11880
gctaacaac  tggaggaac  ggtagagga  agaacacaa  cttatctgg  ggagaagcg  11940
aaagctgag  ccttgcttt  ccagattct  cctcagtga  ttctaagtt  tgcacacat  12000
catgcctat  agcgtgcgc  tgcgcgcac  cacacacac  cacacacac  tacacacac  12060
cacacacac  cgcatataa  catatagcc  tatcctcac  ccacctcac  ttctggtct  12120
tacctaccc  ctcccctca  ctccgtggc  gagcagctg  agagaggcg  gacagtcca  12180
gctgaggcc  ttgatagtg  taccatcta  ttcagtgat  ttgtgggct  tacagctct  12240
tcagcagaa  gcacaccca  gcaggtaag  tggagttca  ccacaggca  caggagtag  12300
tcatcttgg  cgtctggtg  gtacttcct  cccacttgt  cctggtggg  gccctcagt  12360
cccatttct  ttggcttcc  ttgtcttcc  ggtggtgac  ctgctcaat  atctgtaca  12420
ctgttttga  gctgtcata  acaactttg  tgtgtacaa  gtgaggttc  gagtaggga  12480
aggaaggac  ggcagacat  gacagtcag  aaatgttca  agggataca  tgaaacaaa  12540
caaaacaag  ccaggcagt  gtggtgcac  cctttaatt  taccacttg  gggatagag  12600
cagggaaat  tcaatgagt  caaggccag  ctgatctac  gagcaagtt  caggacagc  12660
agagctaca  acagaaaac  aaaatagga  aaggaggtg  agaatggga  aatggggga  12720
gaagaggag  agaggggag  aagaggaag  agaaacaaa  aaaggaaga  agagagaga  12780
agagagaga  agagagaga  agagagaga  agagagaga  agaaaacaa  atagagaca  12840
acaggggga  ctaagaaca  agaaactgg  gtcggtggc  acaaggaaa  ctccagccc  12900
cctgtcctt  cttcttccc  cgccccggc  ccccatagg  ggagaccat  ggtgatgct  12960
acatggtgg  gtcagggct  ccagtgcgg  atggacaac  ccacgcccg  gaggtggcc  13020
gaatggcac  tgcactact  gatgctgtg  gctccttcc  catccgcca  aggccccag  13080
aacagctgc  cttgcgcat  ggcatccac  caggtcaga  tacagaagg  atccagggc  13140
gaaactagg  aacaagact  aacctttat  ccctatctc  caccacaca  cctgggacc  13200
catatcccg  ctcctacct  ttctggggt  ctcacctaa  tcctctaac  tccctggac  13260
cagctccct  cttttcccc  cctaggtcc  gtgtgtgct  gtgtggtag  gctaaagat  13320
ccccgatac  gcctctttg  agacacagt  aacacagct  caagaatgg  gtctaatgg  13380
gaaggtagg  tggcccttc  ggagggaat  agaagggtg  ttgcccagt  catcctgct  13440
cttatgcct  cctagttcc  cagcttgct  ctgccttct  tctgcctac  ctgacttcc  13500
ttatgcaca  aactcccac  ttgtaaatt  agactattg  tgggggtgg  gttgggggt  13560
gggggttaa  aatgcacta  gcccacctt  gccccaaag  ttacttagg  accagaaat  13620
ttttcaaag  acttttatt  gcttacatc  gagcaaagc  atctaacac  atcccactt  13680
ttagagatt  ttaacaagt  gcctaacac  gaggtatgt  atataagat  tttatattc  13740
ttattttaa  atagatctc  ttaagcaac  ctggctggt  ttgaactta  aattctcct  13800
ctctattct  caaactggg  taacaggcc  aagccatca  cttgggaaa  aaagtctat  13860
taataatga  gatgatgat  atgatgatg  ttataatga  aatagttat  taatgtact  13920
atacaccca  aaagatagg  gttttgctg  tgaggtagc  cactgggtt  aggtgcttg  13980
tggccaagt  tggtgacct  agattgatc  ttggaaccc  tatggtacc  ggagagaat  14040
gattccaca  gttgtcctc  gacttccat  tattcaaca  atacccaca  gaatatatg  14100
atacataca  taaatggat  aacattatt  taaatttta  ttttattta  ttatttttt  14160
tttttcgga  ctggggacc  aacccaggg  tttgcgctt  ctaggtaag  gctctacca  14220
tgagctaaa  ccccagccc  tttaaattt  atttttaaa  actacaacg  ggggttggg  14280
atttagctc  gtgctagag  acttgccta  gaagggcaa  gccctgggt  cggtcccca  14340
ctccgaaaa  aagaaccaa  aaaaaaaaa  aaaaaaaaa  ctacaacgt  ctagagtag  14400
agtgcacat  tttagtccc  gcacaaagg  ggcagaggc  ggtggattt  tgagttgga  14460
gccatcccg  tctacagag  gagttccca  acagccagg  ctacacaat  agaccctgc  14520
taatgaaac  aaacaaaaa  caaacaaca  tccacaaag  ctgaaaatg  cctccccac  14580
cacaataaa  aaatacatt  taaaattat  agaaaatgt  atctaaaac  ccaagcatg  14640
gacaaactg  cattctcat  tctgggcct  agctcctcc  cacagcagt  actctgttt  14700
aggattgta  aagatctag  acaattctt  gggtaggca  taggcatct  ataaatgct  14760
ctttccatc  atcccttga  cttgtcccc  gtttcctct  tttttgtgt  tatggctat  14820
gtctgaggc  gtatctcaa  ttgccaagg  tgacttgat  ctctggctg  cacctaacc  14880
aaacgctca  atcacagaa  tgtttcacc  ggtctgttt  tttgtttgt  tgtttgttt  14940
ttttttggt  tgttatttt  tcttgagac  gacactccc  ccccctccc  cccttcctt  15000
ttttgtttg  gtaacaagc  gctctgact  tcctggact  aatttgtag  cccctctgg  15060
ctcaaactc  gagattctg  ctgccactg  ctccacaag  gctaggaat  aatgtatgt  15120
taaccacct  tgtgagagc  tgtggcaga  actaacaga  agacactca  aattcacac  15180
tctgcttcc  ggtgtacac  cacacacac  tacacacac  cacacacac  cacacacat  15240
cacgagaga  agagagaga  agagagaga  agagagaga  agagtacta  gtcaagtaa  15300
tgatctcaa  aacttacat  gtgtttccc  tgggcccca  taaatctag  aactttgtg  15360
gtgctttat  tgcttattt  aggggtcta  agtctcact  aggtggaga  gagtggagt  15420
aaaccctca  acagcactc  cccttttga  ataagctct  tcggggttg  ggatttagc  15480
cagtggtag  gcgcttgcc  aggaagtgc  aggccctgg  ttcggtccc  agctccgga  15540
aaaaaagaa  aaaaaaaaa  aaaaagaac  aaaaaaaaa  aaaagaaat  agctctgtc  15600
ctgagggcc  tttacacac  agggagaca  aggacattg  ttttagtta  ctgaactga  15660
ccaagctga  ctccatact  agttggaac  gcatctgca  tgtgggttc  taaccagtg  15720
tgtacgccc  ctcgggagc  gggtaagtc  gaaaagcaa  cctgggcca  agtattttt  15780
cacagtcaa  aagatgctc  gtaatccct  ccagaattg  gtctcgtct  gagattgat  15840
gcttaaaaa  tgtccgttg  gctgagaat  tgactcact  catagagtg  ttgcctagc  15900
ggaagaaag  gctgggttc  atccctacg  cacataaac  agccttggt  atggtcatt  15960
cagcacatg  caaatggag  cagggaggt  aggaggtca  agtcagttt  gataacatg  16020
cctcttact  caaaagaga  taaacaggg  tgggaaggc  cagagtgtc  gctcagcag  16080
ttagagctc  tcctgctct  gtggagaac  cgcgtgtgt  gtataggta  gtgtatgtt  16140
tgcagtcac  cttcacaag  ttcatctgg  gcttcctga  ctaaaggaa  caagcgcca  16200
gcttcctgg  cttcatctg  ttgcaccct  ctgctccca  ctttggtgc  cctcaccct  16260
ctcccctgt  ctctccagc  ctcaagatc  acttgtctt  agagaccaa  gctgtgctg  16320
aagagttcg  tggtttcga  ctggagctc  gaggggatg  ggaaatgaa  gtagagaag  16380
actccttag  ccccagagg  tcccaaggc  acgcccgta  cttaaatat  tcaagtgat  16440
tgggggagt  ggtgtgcca  tccctaacc  gcctaatct  tttattttc  ccagggcaa  16500
ggcaaggtt  ggacctatt  gctcctggg  gagcgggga  gtagcactc  aggctgacc  16560
actgccctg  tgttccttg  cacccctcc  ccctgtgcc  gaggtgaca  aggtgtcca  16620
cttccacct  tcccacagc  gcccagcca  tgtggaagg  ttagggacc  gaccagcac  16680
gtcaccaga  gtgacctct  agagaggat  gagatggtg  ggactgcag  ggacaccta  16740
gtttgtagg  ctgactgaa  cacacagtc  ctcccatgg  acccttgtg  cacacatgc  16800
cagtcccac  cttactctg  tgcctagat  gggacagcg  ttccttctc  gccctcaac  16860
tagctccac  gtgacttat  gggagggaa  tgccacctg  aggaaacag  aagaggtta  16920
agtttgcag  aggcgggca  tcctgtgtc  caaatactc  cctcacttc  agcccacca  16980
ctgccccac  gactttgga  acagctcac  gaggagaag  gaagctgcc  gttaccttg  17040
ttctcctgt  aaccaaacc  ttaaagtct  tattcctgt  acactgaca  gtttcttct  17100
gggaagaga  ggttgctgg  aaacagtag  gttctttct  taccttctg  ttccaaaag  17160
gttaccttt  gggctgggg  tttagctca  tggtagagc  cttacctag  aagcgcaag  17220
ccctgggtt  ggtccccag  tccaaaaaa  aaaaagaaa  aaaaaagag  taccttcaa  17280
tttgtttct  tttcattgt  gttgatgtt  taactaatt  taagctttc  ttttttttt  17340
tttttttcc  cttcttctc  gagccaggt  tagacctgg  tgtcttgga  ctcactctg  17400
agaccaggc  ggcctggaa  tcacagaga  ccacctacc  actgctggg  ttaaaggca  17460
gtgtggccc  cgaccctgg  taattttac  cttttaatc  acgagacca  agaattc  17517



<210> 2660
<211> 1057
<212> PRT
<213> Rattus norvegicus
<308> AAA41200
<400> 2660

Met Pro Gly Ser Arg Arg Val Arg Pro Arg Leu Arg Ala Leu Leu Leu 
  1               5                  10                  15
Leu Pro Pro Leu Leu Leu Leu Arg Gly Gly His Ala Ser Asp Leu Thr 
             20                  25                  30
Val Ala Val Val Leu Pro Leu Thr Asn Thr Ser Tyr Pro Trp Ser Trp 
         35                  40                  45
Ala Arg Val Gly Pro Ala Val Glu Leu Ala Leu Ala Arg Val Lys Ala 
     50                  55                  60
Arg Pro Asp Leu Leu Pro Gly Trp Thr Val Arg Met Val Leu Gly Ser 
 65                  70                  75                  80
Ser Glu Asn Ala Ala Gly Val Cys Ser Asp Thr Ala Ala Pro Leu Ala 
                 85                  90                  95
Ala Val Asp Leu Lys Trp Glu His Ser Pro Ala Val Phe Leu Gly Pro 
             100                105                110
Gly Cys Val Tyr Ser Ala Ala Pro Val Gly Arg Phe Thr Ala His Trp 
         115                120                125
Arg Val Pro Leu Leu Thr Ala Gly Ala Pro Ala Leu Gly Ile Gly Val 
     130                135                140
Lys Asp Glu Tyr Ala Leu Thr Thr Arg Thr Gly Pro Ser His Val Lys 
 145                150                155                160
Leu Gly Asp Phe Val Thr Ala Leu His Arg Arg Leu Gly Trp Glu His 
                 165                170                175
Gln Ala Leu Val Leu Tyr Ala Asp Arg Leu Gly Asp Asp Arg Pro Cys 
             180                185                190
Phe Phe Ile Val Glu Gly Leu Tyr Met Arg Val Arg Glu Arg Leu Asn 
         195                200                205
Ile Thr Val Asn His Gln Glu Phe Val Glu Gly Asp Pro Asp His Tyr 
     210                215                220
Pro Lys Leu Leu Arg Ala Val Arg Arg Lys Gly Arg Val Ile Tyr Ile 
 225                230                235                240
Cys Ser Ser Pro Asp Ala Phe Arg Asn Leu Met Leu Leu Ala Leu Asn 
                 245                250                255
Ala Gly Leu Thr Gly Glu Asp Tyr Val Phe Phe His Leu Asp Val Phe 
             260                265                270
Gly Gln Ser Leu Lys Ser Ala Gln Gly Leu Val Pro Gln Lys Pro Trp 
         275                280                285
Glu Arg Gly Asp Gly Gln Asp Arg Ser Ala Arg Gln Ala Phe Gln Ala 
     290                295                300
Ala Lys Ile Ile Thr Tyr Lys Glu Pro Asp Asn Pro Glu Tyr Leu Glu 
 305                310                315                320
Phe Leu Lys Gln Leu Lys Leu Leu Ala Asp Lys Lys Phe Asn Phe Thr 
                 325                330                335
Val Glu Asp Gly Leu Lys Asn Ile Ile Pro Ala Ser Phe His Asp Gly 
             340                345                350
Leu Leu Leu Tyr Val Gln Ala Val Thr Glu Thr Leu Ala Gln Gly Gly 
         355                360                365
Thr Val Thr Asp Gly Glu Asn Ile Thr Gln Arg Met Trp Asn Arg Ser 
     370                375                380
Phe Gln Gly Val Thr Gly Tyr Leu Lys Ile Asp Arg Asn Gly Asp Arg 
 385                390                395                400
Asp Thr Asp Phe Ser Leu Trp Asp Met Asp Pro Glu Thr Gly Ala Phe 
                 405                410                415
Arg Val Val Leu Asn Tyr Asn Gly Thr Ser Gln Glu Leu Met Ala Val 
             420                425                430
Ser Glu His Lys Leu Tyr Trp Pro Leu Gly Tyr Pro Pro Pro Asp Val 
         435                440                445
Pro Lys Cys Gly Phe Asp Asn Glu Asp Pro Ala Cys Asn Gln Asp His 
     450                455                460
Phe Ser Thr Leu Glu Val Leu Ala Leu Val Gly Ser Leu Ser Leu Ile 
 465                470                475                480
Ser Phe Leu Ile Val Ser Phe Phe Ile Tyr Arg Lys Met Gln Leu Glu 
                 485                490                495
Lys Glu Leu Val Ser Glu Leu Trp Arg Val Arg Trp Glu Asp Leu Gln 
             500                505                510
Pro Ser Ser Leu Glu Arg His Leu Arg Ser Ala Gly Ser Arg Leu Thr 
         515                520                525
Leu Ser Gly Arg Gly Ser Asn Tyr Gly Ser Leu Leu Thr Thr Glu Gly 
     530                535                540
Gln Phe Gln Val Phe Ala Lys Thr Ala Tyr Tyr Lys Gly Asn Leu Val 
 545                550                555                560
Ala Val Lys Arg Val Asn Arg Lys Arg Ile Glu Leu Thr Arg Lys Val 
                 565                570                575
Leu Phe Glu Leu Lys His Met Arg Asp Val Gln Asn Glu His Leu Thr 
             580                585                590
Arg Phe Val Gly Ala Cys Thr Asp Pro Pro Asn Ile Cys Ile Leu Thr 
         595                600                605
Glu Tyr Cys Pro Arg Gly Ser Leu Gln Asp Ile Leu Glu Asn Glu Ser 
     610                615                620
Ile Thr Leu Asp Trp Met Phe Arg Tyr Ser Leu Thr Asn Asp Ile Val 
 625                630                635                640
Lys Gly Met Leu Phe Leu His Asn Gly Ala Ile Cys Ser His Gly Asn 
                 645                650                655
Leu Lys Ser Ser Asn Cys Val Val Asp Gly Arg Phe Val Leu Lys Ile 
             660                665                670
Thr Asp Tyr Gly Leu Glu Ser Phe Arg Asp Pro Glu Pro Glu Gln Gly 
         675                680                685
His Thr Leu Phe Ala Lys Lys Leu Trp Thr Ala Pro Glu Leu Leu Arg 
     690                695                700
Met Ala Ser Pro Pro Ala Arg Gly Ser Gln Ala Gly Asp Val Tyr Ser 
 705                710                715                720
Phe Gly Ile Ile Leu Gln Glu Ile Ala Leu Arg Ser Gly Val Phe Tyr 
                 725                730                735
Val Glu Gly Leu Asp Leu Ser Pro Lys Glu Ile Ile Glu Arg Val Thr 
             740                745                750
Arg Gly Glu Gln Pro Pro Phe Arg Pro Ser Met Asp Leu Gln Ser His 
         755                760                765
Leu Glu Glu Leu Gly Gln Leu Met Gln Arg Cys Trp Ala Glu Asp Pro 
     770                775                780
Gln Glu Arg Pro Pro Phe Gln Gln Ile Arg Leu Ala Leu Arg Lys Phe 
 785                790                795                800
Asn Lys Glu Asn Ser Ser Asn Ile Leu Asp Asn Leu Leu Ser Arg Met 
                 805                810                815
Glu Gln Tyr Ala Asn Asn Leu Glu Glu Leu Val Glu Glu Arg Thr Gln 
             820                825                830
Ala Tyr Leu Glu Glu Lys Arg Lys Ala Glu Ala Leu Leu Tyr Gln Ile 
         835                840                845
Leu Pro His Ser Val Ala Glu Gln Leu Lys Arg Gly Glu Thr Val Gln 
     850                855                860
Ala Glu Ala Phe Asp Ser Val Thr Ile Tyr Phe Ser Asp Ile Val Gly 
 865                870                875                880
Phe Thr Ala Leu Ser Ala Glu Ser Thr Pro Met Gln Val Val Thr Leu 
                 885                890                895
Leu Asn Asp Leu Tyr Thr Cys Phe Asp Ala Val Ile Asp Asn Phe Asp 
             900                905                910
Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Val Ser Gly 
         915                920                925
Leu Pro Val Arg Asn Gly Gln Leu His Ala Arg Glu Val Ala Arg Met 
     930                935                940
Ala Leu Ala Leu Leu Asp Ala Val Arg Ser Phe Arg Ile Arg His Arg 
 945                950                955                960
Pro Gln Glu Gln Leu Arg Leu Arg Ile Gly Ile His Thr Gly Pro Val 
                 965                970                975
Cys Ala Gly Val Val Gly Leu Lys Met Pro Arg Tyr Cys Leu Phe Gly 
             980                985                990
Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser Asn Gly Glu Ala Leu 
         995                1000                1005
Lys Ile His Leu Ser Ser Glu Thr Lys Ala Val Leu Glu Glu Phe Asp 
     1010                1015                1020
Gly Phe Glu Leu Glu Leu Arg Gly Asp Val Glu Met Lys Gly Lys Gly 
 1025                1030                1035                1040
Lys Val Arg Thr Tyr Trp Leu Leu Gly Glu Arg Gly Cys Ser Thr Arg 
                 1045                1050                1055
Gly 
             1060



<210> 2661
<211> 3482
<212> DNA
<213> Homo sapiens
<308> NM_000907
<400> 2661

atggcgctg  catcacttc  gctgttggt  gcagccctg  caggtgggg  gcgtcctcc  60
ggggcgcgg  acctgacgc  ggcggtggt  ctgccagaa  acaacctga  ctatgcctg  120
gcctggcca  gggtgggac  cgctgtggc  ctagctgtg  aggctctgg  ccgggcact  180
cccgtggac  tgcggtttg  cagctccga  ctggaaggc  cctgctctg  gtacctggc  240
ccgctgagc  ctgtggacc  caagctgta  catgacccc  acctgctgt  aggtcccgg  300
tgcgtgtac  ctgctgcct  tgtggcccg  tttgcctcc  actggcgcc  tcccctgct  360
actgcgggt  ctgtggcct  tggtttttc  gctaagaat  accattatc  taccctggt  420
cgcactggc  cctctgctc  caagctggg  gagtttgtg  tgacactac  cgggcactt  480
aattggact  cccgtgctg  cttgctgta  ctggatgct  gcacagatg  ccggcctca  540
tacttcacc  tcgagggcg  ctttgaggc  ctgcagggc  gcaacctca  tgtgcagca  600
caggtgtat  cccgagagc  agggggccc  gagcaggcc  cccacttca  ccgggccaa  660
gggcgcatt  tgtatatct  cggccctct  gagatgctg  atgagatcc  gcttcaggc  720
cagagggag  atctgacca  tggggatta  gtcttcttt  acctggatg  ctttgggga  780
agtctccgt  caggcccca  acgtgctac  ggccggccc  ggcaggaca  tcgcacccg  840
gaacaggcc  aggccctca  agaggcctt  cagactgta  tggtgatca  gtaccgaga  900
cccccaaat  ctgagtatc  ggaattcca  aatcgtctg  tgataagag  ccgggaaga  960
tttggtgtg  agctgggcc  ttccctgat  aacctcatc  ctggctgct  ctatgatgg  1020
atcctgcta  atgctgaag  cctgaatga  acaatacag  aaggaggca  ccgggagga  1080
ggacttcga  ttgtggaaa  gatgcaggg  cgaagatat  acggtgtaa  tgggctggt  1140
gtcatggac  agaacaatg  ccgagagac  gactttgtc  tctgggcca  gggagacct  1200
gattctggg  actttcagc  tgcagccca  tactcggga  ctgagaagc  gatttggtg  1260
acgggacgg  ctattccct  ggtgaaggg  gctcctccc  cggacaatc  cccctgtgc  1320
tttgacttg  acgacccat  ctgtgataa  actccactt  caaccctgg  aattgtggc  1380
ctgggcaca  gaatcacct  catcatgtt  ggtgtttcc  gcttcctaa  tttccgaaa  1440
ctgatgctg  agaaggagc  ggctagcat  ttgtggcgt  ttcgctggg  agaactgca  1500
tttggcaac  cagagcgtt  tcacaaagg  gcaggcagt  gcctcacac  gtcgctgcg  1560
ggatccagt  acggctcgc  catgacagc  catgggaaa  accagatct  tgccaacac  1620
ggtcacttc  agggaaatg  tgtcgccat  aaacatgtg  ataagaagc  cattgagct  1680
acccggcag  ttctgtttg  actcaaaca  atgagagat  ttcagttca  ccatctcac  1740
cgcttcatt  gcgcctgca  agaccctcc  aacatttgc  ttgtcactg  atactgtcc  1800
cgtgggagt  tacaggata  tctagaaaa  gacagcatc  acttggact  gatgtttcg  1860
tattcactc  ttaatgacc  tgttaaggg  atggccttt  tccacaaca  cattatttc  1920
tcgcatggg  gtctcaagt  ctccaactg  gtggtggat  gtcgttttg  gctcaaaat  1980
acagactat  gcctggcca  cttccgatc  actgctgaa  ctgatgaca  ccatgccct  2040
tatgccaag  agctgtgga  tgccccaga  ctgctcagt  ggaacccct  gccaaccac  2100
ggcatgcag  aggctgacg  ctatagctt  gggatcatc  tgcaggaga  agcacttcg  2160
agtggtcct  tctacttgg  gggcctgga  ctcagcccc  aagagattg  ccagaaggt  2220
cgaaatggt  agcggccat  tttccggcc  agcattgac  ggacccaac  gaatgaaga  2280
ctagttttg  tgatggagc  atgttgggc  caggaccca  ctgagcggc  agactttgg  2340
cagattaag  gcttcattc  gcgctttaa  aaggagggt  gcaccagca  attggacaa  2400
ctcctgctg  gcatggaac  gtatgccaa  aacttggag  agctggtgg  ggaacgcac  2460
caggcctat  tggaggaaa  acgcaaggc  gaagctctg  tctaccaaa  cctacccca  2520
tcagtggca  agcagttaa  acggggaga  actgtacag  ctgaggcct  tgacagtgt  2580
accatctac  tcagtgaca  tgttggctt  acagcattg  cagcagaga  cacccccat  2640
caggtagtg  cacttctta  tgacctgta  acctgcttt  atgccataa  tgacaactt  2700
gatgtctac  aggtggaga  gattgggga  gcttacatg  tggtatctg  cctcccagg  2760
cgaaatggt  aacgccatg  accagaaat  gctcgtatg  ccctagcat  actagatgc  2820
gtttcttcc  ttcgcatcc  ccaccgacc  catgaccag  tgaggctac  cataggggt  2880
catactggt  aggctgact  tcactccag  cctagtctc  acctttccc  gactctccc  2940
acctgtttc  tctcaaagg  ccagtctgt  ctggggttg  tggcctgaa  atgccccgt  3000
attgtcttt  tggagacac  gtgaacact  cttctcgaa  ggagtctaa  ggtcaagcg  3060
tgaagatcc  tgtctcctc  accaccaag  atgccctag  tgagctagg  tgcttccag  3120
tagagcttc  gggggatgt  gaaatgaag  gaaaaggaa  gatgcgaac  tactggctc  3180
taggagagc  gaaaggacc  cctggactc  tgtaaaccc  cattctttc  aagtcagat  3240
gtcttctgc  gctggtacc  gggtgggca  tggccacca  gtctgcaca  accagaaat  3300
gacattttc  tatgcaatg  aaaacagcc  caaaaagac  taccttata  ggaagttgt  3360
gccctctgc  gctcagccc  gtacatata  ctgtccctc  ctggcttgg  ccccttcct  3420
cctactttc  gtaaatatc  gtatctaaa  cagaatatt  tggtcaaat  taaaacaat  3480
at  3482



<210> 2662
<211> 1047
<212> PRT
<213> Homo sapiens
<308> P20594
<400> 2662

Met Ala Leu Pro Ser Leu Leu Leu Leu Val Ala Ala Leu Ala Gly Gly 
  1               5                  10                  15
Val Arg Pro Pro Gly Ala Arg Asn Leu Thr Leu Ala Val Val Leu Pro 
             20                  25                  30
Glu His Asn Leu Ser Tyr Ala Trp Ala Trp Pro Arg Val Gly Pro Ala 
         35                  40                  45
Val Ala Leu Ala Val Glu Ala Leu Gly Arg Ala Leu Pro Val Asp Leu 
     50                  55                  60
Arg Phe Val Ser Ser Glu Leu Glu Gly Ala Cys Ser Glu Tyr Leu Ala 
 65                  70                  75                  80
Pro Leu Ser Ala Val Asp Leu Lys Leu Tyr His Asp Pro Asp Leu Leu 
                 85                  90                  95
Leu Gly Pro Gly Cys Val Tyr Pro Ala Ala Ser Val Ala Arg Phe Ala 
             100                105                110
Ser His Trp Arg Leu Pro Leu Leu Thr Ala Gly Ala Val Ala Ser Gly 
         115                120                125
Phe Ser Ala Lys Asn Asp His Tyr Arg Thr Leu Val Arg Thr Gly Pro 
     130                135                140
Ser Ala Pro Lys Leu Gly Glu Phe Val Val Thr Leu His Gly His Phe 
 145                150                155                160
Asn Trp Thr Ala Arg Ala Ala Leu Leu Tyr Leu Asp Ala Arg Thr Asp 
                 165                170                175
Asp Arg Pro His Tyr Phe Thr Ile Glu Gly Val Phe Glu Ala Leu Gln 
             180                185                190
Gly Ser Asn Leu Ser Val Gln His Gln Val Tyr Ala Arg Glu Pro Gly 
         195                200                205
Gly Pro Glu Gln Ala Thr His Phe Ile Arg Ala Asn Gly Arg Ile Val 
     210                215                220
Tyr Ile Cys Gly Pro Leu Glu Met Leu His Glu Ile Leu Leu Gln Ala 
 225                230                235                240
Gln Arg Glu Asn Leu Thr Asn Gly Asp Tyr Val Phe Phe Tyr Leu Asp 
                 245                250                255
Val Phe Gly Glu Ser Leu Arg Ala Gly Pro Thr Arg Ala Thr Gly Arg 
             260                265                270
Pro Trp Gln Asp Asn Arg Thr Arg Glu Gln Ala Gln Ala Leu Arg Glu 
         275                280                285
Ala Phe Gln Thr Val Leu Val Ile Thr Tyr Arg Glu Pro Pro Asn Pro 
     290                295                300
Glu Tyr Gln Glu Phe Gln Asn Arg Leu Leu Ile Arg Ala Arg Glu Asp 
 305                310                315                320
Phe Gly Val Glu Leu Gly Pro Ser Leu Met Asn Leu Ile Ala Gly Cys 
                 325                330                335
Phe Tyr Asp Gly Ile Leu Leu Tyr Ala Glu Val Leu Asn Glu Thr Ile 
             340                345                350
Gln Glu Gly Gly Thr Arg Glu Asp Gly Leu Arg Ile Val Glu Lys Met 
         355                360                365
Gln Gly Arg Arg Tyr His Gly Val Thr Gly Leu Val Val Met Asp Lys 
     370                375                380
Asn Asn Asp Arg Glu Thr Asp Phe Val Leu Trp Ala Met Gly Asp Leu 
 385                390                395                400
Asp Ser Gly Asp Phe Gln Pro Ala Ala His Tyr Ser Gly Ala Glu Lys 
                 405                410                415
Gln Ile Trp Trp Thr Gly Arg Pro Ile Pro Trp Val Lys Gly Ala Pro 
             420                425                430
Pro Ser Asp Asn Pro Pro Cys Ala Phe Asp Leu Asp Asp Pro Ser Cys 
         435                440                445
Asp Lys Thr Pro Leu Ser Thr Leu Ala Ile Val Ala Leu Gly Thr Gly 
     450                455                460
Ile Thr Phe Ile Met Phe Gly Val Ser Ser Phe Leu Ile Phe Arg Lys 
 465                470                475                480
Leu Met Leu Glu Lys Glu Leu Ala Ser Met Leu Trp Arg Ile Arg Trp 
                 485                490                495
Glu Glu Leu Gln Phe Gly Asn Ser Glu Arg Tyr His Lys Gly Ala Gly 
             500                505                510
Ser Arg Leu Thr Leu Ser Leu Arg Gly Ser Ser Tyr Gly Ser Leu Met 
         515                520                525
Thr Ala His Gly Lys Tyr Gln Ile Phe Ala Asn Thr Gly His Phe Lys 
     530                535                540
Gly Asn Val Val Ala Ile Lys His Val Asn Lys Lys Arg Ile Glu Leu 
 545                550                555                560
Thr Arg Gln Val Leu Phe Glu Leu Lys His Met Arg Asp Val Gln Phe 
                 565                570                575
Asn His Leu Thr Arg Phe Ile Gly Ala Cys Ile Asp Pro Pro Asn Ile 
             580                585                590
Cys Ile Val Thr Glu Tyr Cys Pro Arg Gly Ser Leu Gln Asp Ile Leu 
         595                600                605
Glu Asn Asp Ser Ile Asn Leu Asp Trp Met Phe Arg Tyr Ser Leu Ile 
     610                615                620
Asn Asp Leu Val Lys Gly Met Ala Phe Leu His Asn Ser Ile Ile Ser 
 625                630                635                640
Ser His Gly Ser Leu Lys Ser Ser Asn Cys Val Val Asp Ser Arg Phe 
                 645                650                655
Val Leu Lys Ile Thr Asp Tyr Gly Leu Ala Ser Phe Arg Ser Thr Ala 
             660                665                670
Glu Pro Asp Asp Ser His Ala Leu Tyr Ala Lys Lys Leu Trp Thr Ala 
         675                680                685
Pro Glu Leu Leu Ser Gly Asn Pro Leu Pro Thr Thr Gly Met Gln Lys 
     690                695                700
Ala Asp Val Tyr Ser Phe Gly Ile Ile Leu Gln Glu Ile Ala Leu Arg 
 705                710                715                720
Ser Gly Pro Phe Tyr Leu Glu Gly Leu Asp Leu Ser Pro Lys Glu Ile 
                 725                730                735
Val Gln Lys Val Arg Asn Gly Gln Arg Pro Tyr Phe Arg Pro Ser Ile 
             740                745                750
Asp Arg Thr Gln Leu Asn Glu Glu Leu Val Leu Leu Met Glu Arg Cys 
         755                760                765
Trp Ala Gln Asp Pro Ala Glu Arg Pro Asp Phe Gly Gln Ile Lys Gly 
     770                775                780
Phe Ile Arg Arg Phe Asn Lys Glu Gly Gly Thr Ser Ile Leu Asp Asn 
 785                790                795                800
Leu Leu Leu Arg Met Glu Gln Tyr Ala Asn Asn Leu Glu Lys Leu Val 
                 805                810                815
Glu Glu Arg Thr Gln Ala Tyr Leu Glu Glu Lys Arg Lys Ala Glu Ala 
             820                825                830
Leu Leu Tyr Gln Ile Leu Pro His Ser Val Ala Glu Gln Leu Lys Arg 
         835                840                845
Gly Glu Thr Val Gln Ala Glu Ala Phe Asp Ser Val Thr Ile Tyr Phe 
     850                855                860
Ser Asp Ile Val Gly Phe Thr Ala Leu Ser Ala Glu Ser Thr Pro Met 
 865                870                875                880
Gln Val Val Thr Leu Leu Asn Asp Leu Tyr Thr Cys Phe Asp Ala Ile 
                 885                890                895
Ile Asp Asn Phe Asp Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr 
             900                905                910
Met Val Val Ser Gly Leu Pro Gly Arg Asn Gly Gln Arg His Ala Pro 
         915                920                925
Glu Ile Ala Arg Met Ala Leu Ala Leu Leu Asp Ala Val Ser Ser Phe 
     930                935                940
Arg Ile Arg His Arg Pro His Asp Gln Leu Arg Leu Arg Ile Gly Val 
 945                950                955                960
His Thr Gly Pro Val Cys Ala Gly Val Val Gly Leu Lys Met Pro Arg 
                 965                970                975
Tyr Cys Leu Phe Gly Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser 
             980                985                990
Asn Gly Gln Ala Leu Lys Ile His Val Ser Ser Thr Thr Lys Asp Ala 
         995                1000                1005
Leu Asp Glu Leu Gly Cys Phe Gln Leu Glu Leu Arg Gly Asp Val Glu 
     1010                1015                1020
Met Lys Gly Lys Gly Lys Met Arg Thr Tyr Trp Leu Leu Gly Glu Arg 
 1025                1030                1035                1040
Lys Gly Pro Pro Gly Leu Leu 
                 1045



<210> 2663
<211> 1464
<212> DNA
<213> Rattus norvegicus
<308> K00512
<400> 2663

ttcggcttc  gaaggcctg  tgtgatggc  tcacagaag  gaccctcac  gcgacacgg  60
tccaagtac  tggccacag  aagtaccat  gaccatgcc  ggcatggct  cctcccaag  120
cacagagac  cgggcatcc  tgactccat  gggcgcttc  ttagcggtg  caggggtgc  180
cccaagcgg  gctctggca  ggactcaca  acaagaact  cccactacg  ctccctgcc  240
cagaagtcg  agaggaccc  agatgaaaa  ccagtagtc  acttcttca  gaacattgt  300
acacctcgt  caccccctc  atcccaagg  aaggggaga  gcctgtccc  cagcagatt  360
agctgggga  gaagagaca  ccgctctgg  tctcccata  caagacgct  agagcctcc  420
tgctcagcc  tcccgaatc  tgccctcgg  ttcttaata  aactgcctt  aacgtttaa  480
tctacttgc  ccaaatagc  agttagagc  gaccctctc  taatcccgt  gggctgtga  540
cgcggcggg  cagcccacg  caccctgac  ggctaaaac  gtttgtccc  ttttatttg  600
agattgagt  tcctcgggg  cttctctgc  ccgacttgc  ccccgtgta  cttggtcga  660
tccggaggt  caggtgcac  gacaccctt  caagttcac  cctactcca  cctcagact  720
tcttttcac  gcgaggcgc  cccctccag  ttccgtggg  actgcggat  gacaggcac  780
ccgccaagg  gccagagag  atggcgcag  ggactatgt  gtccaggct  cctttgttt  840
ctttcccct  aagagcttt  tttttcctg  caggatcag  cagtcttgg  gtggcttac  900
caacggggg  ttgtggtat  tgagcacag  tcgggcagc  gtgagagtc  agagtgggg  960
ggccctggg  acgcttcca  gccagcggt  ccctgcacc  caccagctg  tttcgagcg  1020
ggcagaggg  aggaaaggg  cgagcgggc  gggcaatgg  cccgacagg  aacggggac  1080
taggggaac  cgctggaga  gccatgtgt  gctgccgaa  gtcaccatc  ctcctcagt  1140
ctccccaga  caggtgctt  taagaaccc  gtttcctct  agagcctag  gagagtcca  1200
ggacatggc  catcaggaa  tgggactgc  ggagttctc  ggtggcctc  tgctgtccc  1260
ctggccact  ctcacttta  ggtggtcac  gcagctcgc  atggcagtg  cattggtgc  1320
cactaacct  atggaaaag  aaccattcc  tgcctctta  aaagaactc  ttcttagtt  1380
taggagggt  cctgtcgct  aatcaagtc  ctgccctga  gcagggctg  ccttggcga  1440
cctccaggg  tgaggagct  agaa  1464



<210> 2664
<211> 194
<212> PRT
<213> Rattus norvegicus
<308> P02688
<400> 2664

Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu Ala 
  1               5                  10                  15
Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg His 
             20                  25                  30
Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Ser Gly Asp 
         35                  40                  45
Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys Gln 
     50                  55                  60
Ser Arg Ser Pro Leu Pro Ser His Ala Arg Ser Arg Pro Gly Leu Cys 
 65                  70                  75                  80
His Met Tyr Lys Asp Ser His Thr Arg Thr Thr His Tyr Gly Ser Leu 
                 85                  90                  95
Pro Gln Lys Ser Gln Arg Thr Gln Asp Glu Asn Pro Val Val His Phe 
             100                105                110
Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys 
         115                120                125
Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln 
     130                135                140
Lys Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala 
 145                150                155                160
His Lys Gly Phe Lys Gly Ala Tyr Asp Ala Gln Gly Thr Leu Ser Lys 
                 165                170                175
Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala 
             180                185                190
Arg Arg 
         195



<210> 2665
<211> 2528
<212> DNA
<213> Rattus norvegicus
<308> K00750
<400> 2665

gctcctccc  aacacgcag  ccggagggt  acgtcatcc  cgtccacgc  ttacgtcca  60
gggcctgtc  taagtgtcg  gcaaacgag  cctctagag  aagggcgcc  tctcggtac  120
acctaccat  ctagcccgc  tgcgcgcgc  ccttgctag  gctcccaat  ctggagcca  180
tgacatgcg  ctacgtcac  gcgcagtgc  cggcgctgc  gcacgtccg  ccgcgggag  240
gcagaacaa  tgtggttgc  ttgacaccg  tacataggc  cgggccggc  tgtccttgg  300
ctagagagc  ggacgtctc  ctaagagtc  gatcctttg  ggtgttgac  agcccggac  360
ggtgagcgc  cgacgggga  gcggggcgg  agagggcga  gagaccgag  caggcctga  420
ctacaaaga  atgcggaac  gtggaggct  cgtgggtga  gggctgggg  cagagttct  480
gagggagct  gcccgccgc  ccttctgag  gcagaagct  ctgtttctt  agaactggg  540
tggttcttt  tctgattaa  tttctggaa  ggtgggttt  ttcagtccc  tttggatga  600
ctcgtggtt  cccctggga  ctcagaacg  gtagagtga  aaggttcct  cccttgcct  660
cccgggccg  actaatgca  gagtgactt  acctccaaa  gagaccaga  caggaggag  720
aagcactta  gatcttcag  ccccgagcc  cattgatgt  ttttccctt  tctttggaa  780
tgactttaa  tgacagcac  gacagcaat  aagcattct  aaatgctaa  aggtatagt  840
gttttggct  aacaaaatt  tagtctagt  tcatatttg  ctttttgac  ttgccttct  900
cagaaactg  agcttgaac  gtgggtttc  atttccctt  cttgggcat  agcctgtct  960
gaaagtttg  tttaatcct  aataacgcg  ttgctgttg  aggatattg  aaacagact  1020
agttattag  tagcatcca  cctggtggt  gtattgtaa  gggttggta  ttaagtgat  1080
tgagtggtc  ttgggatcc  tagtatgtt  tgctgtaac  agtgacttg  accgttggg  1140
ctttttcat  tctagaatt  aaaatgggt  atgttgaaa  aggcaagaa  atttttgtt  1200
aaaagtgtg  ccagtgcca  actgtggaa  aaggaggca  gcataagac  ggaccaaac  1260
tccatggtc  gtttgggcg  aagacaggc  aggctgctg  attctctta  acagatgcc  1320
acaagaaca  aggtaagtg  ggagctgct  ttcagacag  gcacaggtt  catgggtgt  1380
accaatgca  acttatcag  tataaaaca  ttaactgct  catctcttt  tgtgtaggt  1440
tcacctggg  agaggatac  ctgatggag  atttggaaa  tcccaaaaa  tacatccct  1500
gaacaaaaa  gatcttcgc  ggaattaag  agaagggag  aagggcaga  ctaatagct  1560
atcttaaaa  ggctactaa  gaataattc  actgcctta  ttattacaa  acaaatgtc  1620
catggcttt  aatgtatac  ataatttaa  tcatacacc  aattcagat  atgaatggc  1680
aacaatgtt  ttgttggac  gccccgatt  aagtaaaat  gacttgtca  aaagtggat  1740
tgatctttt  taaagtaac  cttccaatt  aatacatgt  atcactgct  tccctttct  1800
aagataaga  tggacttaa  tagtaatat  ttcctttcc  taaatagga  ggtgtcgcc  1860
caaacctat  gaatggttt  atacttaga  ttatataac  gggtatatg  atatgttca  1920
atcctggga  aattctgtc  ctgtctgag  aacaagaag  ctcacccgt  cttcagtgt  1980
tgtaaactg  cctctgaca  gcaatgcta  acaccagga  ggaactatt  ttgacagtg  2040
tgttttaat  agaattccc  acatcaatg  tgctgcctt  caccactga  aggcattta  2100
tgtggttta  gtatgatat  aaataaaga  tatttaaca  ttctttata  ttgatctac  2160
agttaaaat  cttttaaga  caagttagg  cttttaaat  ttctcttat  taagactaa  2220
ctgtaattc  gaattgtcc  taaatgccc  ttcggaaag  cataactgg  atttctgtt  2280
atgcctgat  gggagtggt  ctcttttct  acttactag  tggaaagat  aaaataaag  2340
agataattt  taagttatc  acagtcaga  gataattaa  tcaatcaca  atcatgatc  2400
tttgattgt  ctttaatga  ggttggcaa  acttaagct  tttaaactt  ccctagtaa  2460
accgtggtc  agtgaaagc  ctggttgat  ttaccttga  acggggaca  ctcagacta  2520
agcaacac  2528



<210> 2666
<211> 104
<212> PRT
<213> Rattus norvegicus
<308> AAA21711
<400> 2666

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Val Gln Lys Cys Ala Gln 
  1               5                  10                  15
Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
             20                  25                  30
His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Ala Gly Phe Ser Tyr 
         35                  40                  45
Thr Asp Ala Asn Lys Asn Lys Gly Ile Thr Trp Gly Glu Asp Thr Leu 
     50                  55                  60
Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
 65                  70                  75                  80
Ile Phe Ala Gly Ile Lys Lys Lys Gly Glu Arg Ala Asp Leu Ile Ala 
                 85                  90                  95
Tyr Leu Lys Lys Ala Thr Asn Glu 
             100



<210> 2667
<211> 3990
<212> DNA
<213> Homo sapiens
<308> NM_018947
<400> 2667

ggacgtccg  cttcggagc  ggagtgttc  ttgtgccag  gactaaaaa  agaattaaa  60
atgggtgat  ttgagaaag  caagaagat  tttattatg  agtgttccc  gtgccacac  120
gttgaaaag  gaggcaagc  caagactgg  ccaaatctc  atggtctct  tgggcggaa  180
acaggtcag  cccctggat  ctcttacac  gccgccaat  agaacaaag  catcatctg  240
ggagaggat  cactgatgg  gtatttgga  aatcccaag  agtacatcc  tggaacaaa  300
atgatcttt  tcggcatta  gaagaagga  gaaagggca  acttaatag  ttatctcaa  360
aaagctact  atgagtaat  attggccac  gccttattt  ttacaaaac  gaaatgtct  420
atgactttt  tatgtgtac  atcctttaa  agatctcat  caccagaat  cagatcatg  480
atgactgac  gaatatttt  ttgggcagt  ctgatttaa  actaagact  gcttgtggt  540
aaatgaata  gttcagttt  tgaatttta  tagtaactc  aattcagta  atggtatca  600
tgtttaccc  ttttaaaga  atgattaga  ttcgttagt  atgttcaac  tttcacaaa  660
atggtgagt  ccatcttaa  acttactgg  gattggttt  atatttaga  ttatataac  720
ggttatgtg  atatattta  atactgggg  aattgcttc  ctgtcttag  accaagcaa  780
attcacctg  gttttgtgt  catgttcat  tgcctctta  aggcaaggg  tgaagataa  840
taaggttgc  atgtctata  ttttggcct  aactatgcc  atctaatta  aattccctg  900
atttaaaat  gtttctttt  cttattgaa  ggcatttta  tgtggttta  gtgtaatat  960
aaagattat  caacacctc  cacatctta  agatctata  ggtcacatg  ttttaaaat  1020
gtagcaagt  aaacttcac  cttgaattc  ttacaatct  agtcaaact  agttataat  1080
taggattgt  tttaaacag  cattcagaa  caaaactgt  gaactgtgt  tttgattgg  1140
aatggtgct  ttgccaact  aaaaggatt  aagtaacgg  gatatacac  aattttaaa  1200
ttatgtgtg  tcacaagac  aaagataat  aaaaagaaa  ccacagatc  tgacttttt  1260
actgtgctt  atttcatga  tgatgcaca  attttaatg  ttaaaaagt  caggagccc  1320
aaatgtcag  gcagcagcc  taaatgtca  tgcagcagt  ttaaccagt  atggtgcta  1380
attgtttac  tggttttct  ggactgcct  aactagaat  acacttcac  aattgactc  1440
tagtttctt  gctcagatt  agaactgca  catttatgc  agacatgga  agaggaatg  1500
ctgtggtca  agttttgtg  tgtgtaaca  tgtataatt  catactgaa  tatttcatg  1560
atagtctgt  ccatacaca  ttagagtag  ccttggaga  tttatggag  tggtgagca  1620
aaggtaagt  ataaagaat  atgagaaaa  aaatctatg  tggtgcagc  gagaactgt  1680
tctttgtgg  acagtgaga  gactgagaa  atgtgaatc  atggtctca  aggtgatag  1740
gacgattag  taggtgttt  aaggcctga  agcaattta  aacatatga  tcttatttt  1800
atttataga  atgtggaaa  cttgctgta  ttcatattt  aagtcctag  ctgagttct  1860
gtggggaat  taaaaatgc  tcctggaaa  cctttaaag  tttcagact  tgaaaggcc  1920
tgtagcaga  gacttggtg  ctgtataaa  ttagtggta  tcagggaca  tgtagcaag  1980
agcttacaa  gggacaatt  tggactaat  agaaagacc  gaagtgaag  ctagagagt  2040
gattttttt  ttttttggc  tcctggaaa  gatacagga  acatattaa  atagataca  2100
aaatgtgtt  aaccttcca  cttggctag  tgtggcgtt  agtttgttt  ttgagacat  2160
gtcacgctg  gtcgccaag  ctggagtgc  gtggtgcga  ctcggctgg  tgcagcctc  2220
atttcccag  ctcaagcga  tctctcact  cagcttccc  agtagctgg  actgcgggt  2280
ttcgccacc  tgcccagct  atttttttg  agagatgga  ttttgccat  tggtcccag  2340
ctggtctca  actcctgag  tcaagcaat  cgtccactt  ccttggctc  ccaaagtgc  2400
gggattgca  gcgtgagcc  ccaggccct  cctggtttt  aaattcaga  atcttatta  2460
ttaacccag  agtaatcag  ccagtagta  cttaggttt  atttttttt  aggtttaaa  2520
tttttctca  ttatttttt  tgagacgga  tttcgccct  ttcgcccag  ctgagtaca  2580
tggtgcaat  tcactgcaa  ctccgcctt  cagttgcaa  tgattctcc  gcctcagcc  2640
cctgagtag  tgggattgc  ggcacccgc  accacgcct  gctaatttt  gtattttta  2700
tggagatgg  gtttcacca  gttggccag  ctggtcttg  actcctgac  tcgtgatcc  2760
cccaccttg  cctcccaaa  ttctaggat  acaggtgtg  gccaccacg  ccggccaat  2820
tttctcatt  ctatgcctc  tatattaag  tctgtgttg  cacagatga  taactgcca  2880
gttctaggt  agttatacc  aagcacttc  ggtggttta  aatgtgatt  tgtaacttt  2940
ttattttta  ttttttgag  taatttcac  cttgttgcc  aggctggag  gcaatggcg  3000
gatcgctgc  caccgcaac  tccgccttc  aggttcaag  gattctcct  actcagcct  3060
tcaagtagc  gggattaca  gcatgcgcc  ccatgccca  cttattttg  gtttttagt  3120
gagacaggg  ttctccatg  tggacaggc  ggtcttgaa  tcccgacgt  gggtgatct  3180
cctgcctcg  cctcccaaa  tgctgggat  acaggcgtg  gccaccacg  ctggccaat  3240
atgtaattt  ttaaaaagg  catttctat  agggatata  accttcaga  ataaggaaa  3300
aggggaaaa  aagagcact  taaaccaca  gttttcatt  ctagtgctt  gctgtaagt  3360
gctaggttg  tagaatcaa  aacaagggc  agatgtatt  aaggggtat  cagatgcca  3420
ctacatgct  attttgtct  gaacagtgc  gtctaatag  actttctgt  acgatggat  3480
ttttgtaga  ttttgctgt  cagtgtggt  gccactaac  acatgtggc  gttaagccc  3540
tgaaatata  ctagtgtga  tagaaagta  tttatttta  atttacata  gcacaagtg  3600
ctagtggct  ctgtattga  attctgggt  taggactag  accagtggt  tgtaacaaa  3660
gtactttct  tttactcta  taaatctag  attagccgg  catggtcgc  catgcctgt  3720
gtcccagca  tttgggagg  caaggcagg  agatcactt  aggtcgggc  tttgagacc  3780
gcctggtca  catggcgaa  ccctgtctc  acaaaaaac  taaaagtta  ccaggtgtg  3840
tggtgggca  ctgtagtct  agctacttg  gaggctgag  cacaagaat  acttgaact  3900
gggaggtgg  ggttgcagt  agccaggat  gtgccactg  actcaagcc  gggtgacga  3960
tgaaactgt  tccaaaaaa  aaaaaaaaaa  3990



<210> 2668
<211> 104
<212> PRT
<213> Homo sapiens
<308> P00001
<400> 2668

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser Gln 
  1               5                  10                  15
Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
             20                  25                  30
His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Pro Gly Tyr Ser Tyr 
         35                  40                  45
Thr Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Thr Leu 
     50                  55                  60
Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
 65                  70                  75                  80
Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile Ala 
                 85                  90                  95
Tyr Leu Lys Lys Ala Thr Asn Glu 
             100



<210> 2669
<211> 2528
<212> DNA
<213> Rattus norvegicus
<308> K00750
<400> 2669

gctcctccc  aacacgcag  ccggagggt  acgtcatcc  cgtccacgc  ttacgtcca  60
gggcctgtc  taagtgtcg  gcaaacgag  cctctagag  aagggcgcc  tctcggtac  120
acctaccat  ctagcccgc  tgcgcgcgc  ccttgctag  gctcccaat  ctggagcca  180
tgacatgcg  ctacgtcac  gcgcagtgc  cggcgctgc  gcacgtccg  ccgcgggag  240
gcagaacaa  tgtggttgc  ttgacaccg  tacataggc  cgggccggc  tgtccttgg  300
ctagagagc  ggacgtctc  ctaagagtc  gatcctttg  ggtgttgac  agcccggac  360
ggtgagcgc  cgacgggga  gcggggcgg  agagggcga  gagaccgag  caggcctga  420
ctacaaaga  atgcggaac  gtggaggct  cgtgggtga  gggctgggg  cagagttct  480
gagggagct  gcccgccgc  ccttctgag  gcagaagct  ctgtttctt  agaactggg  540
tggttcttt  tctgattaa  tttctggaa  ggtgggttt  ttcagtccc  tttggatga  600
ctcgtggtt  cccctggga  ctcagaacg  gtagagtga  aaggttcct  cccttgcct  660
cccgggccg  actaatgca  gagtgactt  acctccaaa  gagaccaga  caggaggag  720
aagcactta  gatcttcag  ccccgagcc  cattgatgt  ttttccctt  tctttggaa  780
tgactttaa  tgacagcac  gacagcaat  aagcattct  aaatgctaa  aggtatagt  840
gttttggct  aacaaaatt  tagtctagt  tcatatttg  ctttttgac  ttgccttct  900
cagaaactg  agcttgaac  gtgggtttc  atttccctt  cttgggcat  agcctgtct  960
gaaagtttg  tttaatcct  aataacgcg  ttgctgttg  aggatattg  aaacagact  1020
agttattag  tagcatcca  cctggtggt  gtattgtaa  gggttggta  ttaagtgat  1080
tgagtggtc  ttgggatcc  tagtatgtt  tgctgtaac  agtgacttg  accgttggg  1140
ctttttcat  tctagaatt  aaaatgggt  atgttgaaa  aggcaagaa  atttttgtt  1200
aaaagtgtg  ccagtgcca  actgtggaa  aaggaggca  gcataagac  ggaccaaac  1260
tccatggtc  gtttgggcg  aagacaggc  aggctgctg  attctctta  acagatgcc  1320
acaagaaca  aggtaagtg  ggagctgct  ttcagacag  gcacaggtt  catgggtgt  1380
accaatgca  acttatcag  tataaaaca  ttaactgct  catctcttt  tgtgtaggt  1440
tcacctggg  agaggatac  ctgatggag  atttggaaa  tcccaaaaa  tacatccct  1500
gaacaaaaa  gatcttcgc  ggaattaag  agaagggag  aagggcaga  ctaatagct  1560
atcttaaaa  ggctactaa  gaataattc  actgcctta  ttattacaa  acaaatgtc  1620
catggcttt  aatgtatac  ataatttaa  tcatacacc  aattcagat  atgaatggc  1680
aacaatgtt  ttgttggac  gccccgatt  aagtaaaat  gacttgtca  aaagtggat  1740
tgatctttt  taaagtaac  cttccaatt  aatacatgt  atcactgct  tccctttct  1800
aagataaga  tggacttaa  tagtaatat  ttcctttcc  taaatagga  ggtgtcgcc  1860
caaacctat  gaatggttt  atacttaga  ttatataac  gggtatatg  atatgttca  1920
atcctggga  aattctgtc  ctgtctgag  aacaagaag  ctcacccgt  cttcagtgt  1980
tgtaaactg  cctctgaca  gcaatgcta  acaccagga  ggaactatt  ttgacagtg  2040
tgttttaat  agaattccc  acatcaatg  tgctgcctt  caccactga  aggcattta  2100
tgtggttta  gtatgatat  aaataaaga  tatttaaca  ttctttata  ttgatctac  2160
agttaaaat  cttttaaga  caagttagg  cttttaaat  ttctcttat  taagactaa  2220
ctgtaattc  gaattgtcc  taaatgccc  ttcggaaag  cataactgg  atttctgtt  2280
atgcctgat  gggagtggt  ctcttttct  acttactag  tggaaagat  aaaataaag  2340
agataattt  taagttatc  acagtcaga  gataattaa  tcaatcaca  atcatgatc  2400
tttgattgt  ctttaatga  ggttggcaa  acttaagct  tttaaactt  ccctagtaa  2460
accgtggtc  agtgaaagc  ctggttgat  ttaccttga  acggggaca  ctcagacta  2520
agcaacac  2528



<210> 2670
<211> 104
<212> PRT
<213> Rattus norvegicus
<308> AAA21711
<400> 2670

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Val Gln Lys Cys Ala Gln 
  1               5                  10                  15
Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
             20                  25                  30
His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Ala Gly Phe Ser Tyr 
         35                  40                  45
Thr Asp Ala Asn Lys Asn Lys Gly Ile Thr Trp Gly Glu Asp Thr Leu 
     50                  55                  60
Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
 65                  70                  75                  80
Ile Phe Ala Gly Ile Lys Lys Lys Gly Glu Arg Ala Asp Leu Ile Ala 
                 85                  90                  95
Tyr Leu Lys Lys Ala Thr Asn Glu 
             100



<210> 2671
<211> 3990
<212> DNA
<213> Homo sapiens
<308> NM_018947
<400> 2671

ggacgtccg  cttcggagc  ggagtgttc  ttgtgccag  gactaaaaa  agaattaaa  60
atgggtgat  ttgagaaag  caagaagat  tttattatg  agtgttccc  gtgccacac  120
gttgaaaag  gaggcaagc  caagactgg  ccaaatctc  atggtctct  tgggcggaa  180
acaggtcag  cccctggat  ctcttacac  gccgccaat  agaacaaag  catcatctg  240
ggagaggat  cactgatgg  gtatttgga  aatcccaag  agtacatcc  tggaacaaa  300
atgatcttt  tcggcatta  gaagaagga  gaaagggca  acttaatag  ttatctcaa  360
aaagctact  atgagtaat  attggccac  gccttattt  ttacaaaac  gaaatgtct  420
atgactttt  tatgtgtac  atcctttaa  agatctcat  caccagaat  cagatcatg  480
atgactgac  gaatatttt  ttgggcagt  ctgatttaa  actaagact  gcttgtggt  540
aaatgaata  gttcagttt  tgaatttta  tagtaactc  aattcagta  atggtatca  600
tgtttaccc  ttttaaaga  atgattaga  ttcgttagt  atgttcaac  tttcacaaa  660
atggtgagt  ccatcttaa  acttactgg  gattggttt  atatttaga  ttatataac  720
ggttatgtg  atatattta  atactgggg  aattgcttc  ctgtcttag  accaagcaa  780
attcacctg  gttttgtgt  catgttcat  tgcctctta  aggcaaggg  tgaagataa  840
taaggttgc  atgtctata  ttttggcct  aactatgcc  atctaatta  aattccctg  900
atttaaaat  gtttctttt  cttattgaa  ggcatttta  tgtggttta  gtgtaatat  960
aaagattat  caacacctc  cacatctta  agatctata  ggtcacatg  ttttaaaat  1020
gtagcaagt  aaacttcac  cttgaattc  ttacaatct  agtcaaact  agttataat  1080
taggattgt  tttaaacag  cattcagaa  caaaactgt  gaactgtgt  tttgattgg  1140
aatggtgct  ttgccaact  aaaaggatt  aagtaacgg  gatatacac  aattttaaa  1200
ttatgtgtg  tcacaagac  aaagataat  aaaaagaaa  ccacagatc  tgacttttt  1260
actgtgctt  atttcatga  tgatgcaca  attttaatg  ttaaaaagt  caggagccc  1320
aaatgtcag  gcagcagcc  taaatgtca  tgcagcagt  ttaaccagt  atggtgcta  1380
attgtttac  tggttttct  ggactgcct  aactagaat  acacttcac  aattgactc  1440
tagtttctt  gctcagatt  agaactgca  catttatgc  agacatgga  agaggaatg  1500
ctgtggtca  agttttgtg  tgtgtaaca  tgtataatt  catactgaa  tatttcatg  1560
atagtctgt  ccatacaca  ttagagtag  ccttggaga  tttatggag  tggtgagca  1620
aaggtaagt  ataaagaat  atgagaaaa  aaatctatg  tggtgcagc  gagaactgt  1680
tctttgtgg  acagtgaga  gactgagaa  atgtgaatc  atggtctca  aggtgatag  1740
gacgattag  taggtgttt  aaggcctga  agcaattta  aacatatga  tcttatttt  1800
atttataga  atgtggaaa  cttgctgta  ttcatattt  aagtcctag  ctgagttct  1860
gtggggaat  taaaaatgc  tcctggaaa  cctttaaag  tttcagact  tgaaaggcc  1920
tgtagcaga  gacttggtg  ctgtataaa  ttagtggta  tcagggaca  tgtagcaag  1980
agcttacaa  gggacaatt  tggactaat  agaaagacc  gaagtgaag  ctagagagt  2040
gattttttt  ttttttggc  tcctggaaa  gatacagga  acatattaa  atagataca  2100
aaatgtgtt  aaccttcca  cttggctag  tgtggcgtt  agtttgttt  ttgagacat  2160
gtcacgctg  gtcgccaag  ctggagtgc  gtggtgcga  ctcggctgg  tgcagcctc  2220
atttcccag  ctcaagcga  tctctcact  cagcttccc  agtagctgg  actgcgggt  2280
ttcgccacc  tgcccagct  atttttttg  agagatgga  ttttgccat  tggtcccag  2340
ctggtctca  actcctgag  tcaagcaat  cgtccactt  ccttggctc  ccaaagtgc  2400
gggattgca  gcgtgagcc  ccaggccct  cctggtttt  aaattcaga  atcttatta  2460
ttaacccag  agtaatcag  ccagtagta  cttaggttt  atttttttt  aggtttaaa  2520
tttttctca  ttatttttt  tgagacgga  tttcgccct  ttcgcccag  ctgagtaca  2580
tggtgcaat  tcactgcaa  ctccgcctt  cagttgcaa  tgattctcc  gcctcagcc  2640
cctgagtag  tgggattgc  ggcacccgc  accacgcct  gctaatttt  gtattttta  2700
tggagatgg  gtttcacca  gttggccag  ctggtcttg  actcctgac  tcgtgatcc  2760
cccaccttg  cctcccaaa  ttctaggat  acaggtgtg  gccaccacg  ccggccaat  2820
tttctcatt  ctatgcctc  tatattaag  tctgtgttg  cacagatga  taactgcca  2880
gttctaggt  agttatacc  aagcacttc  ggtggttta  aatgtgatt  tgtaacttt  2940
ttattttta  ttttttgag  taatttcac  cttgttgcc  aggctggag  gcaatggcg  3000
gatcgctgc  caccgcaac  tccgccttc  aggttcaag  gattctcct  actcagcct  3060
tcaagtagc  gggattaca  gcatgcgcc  ccatgccca  cttattttg  gtttttagt  3120
gagacaggg  ttctccatg  tggacaggc  ggtcttgaa  tcccgacgt  gggtgatct  3180
cctgcctcg  cctcccaaa  tgctgggat  acaggcgtg  gccaccacg  ctggccaat  3240
atgtaattt  ttaaaaagg  catttctat  agggatata  accttcaga  ataaggaaa  3300
aggggaaaa  aagagcact  taaaccaca  gttttcatt  ctagtgctt  gctgtaagt  3360
gctaggttg  tagaatcaa  aacaagggc  agatgtatt  aaggggtat  cagatgcca  3420
ctacatgct  attttgtct  gaacagtgc  gtctaatag  actttctgt  acgatggat  3480
ttttgtaga  ttttgctgt  cagtgtggt  gccactaac  acatgtggc  gttaagccc  3540
tgaaatata  ctagtgtga  tagaaagta  tttatttta  atttacata  gcacaagtg  3600
ctagtggct  ctgtattga  attctgggt  taggactag  accagtggt  tgtaacaaa  3660
gtactttct  tttactcta  taaatctag  attagccgg  catggtcgc  catgcctgt  3720
gtcccagca  tttgggagg  caaggcagg  agatcactt  aggtcgggc  tttgagacc  3780
gcctggtca  catggcgaa  ccctgtctc  acaaaaaac  taaaagtta  ccaggtgtg  3840
tggtgggca  ctgtagtct  agctacttg  gaggctgag  cacaagaat  acttgaact  3900
gggaggtgg  ggttgcagt  agccaggat  gtgccactg  actcaagcc  gggtgacga  3960
tgaaactgt  tccaaaaaa  aaaaaaaaaa  3990



<210> 2672
<211> 104
<212> PRT
<213> Homo sapiens
<308> P00001
<400> 2672

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser Gln 
  1               5                  10                  15
Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
             20                  25                  30
His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Pro Gly Tyr Ser Tyr 
         35                  40                  45
Thr Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Thr Leu 
     50                  55                  60
Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
 65                  70                  75                  80
Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile Ala 
                 85                  90                  95
Tyr Leu Lys Lys Ala Thr Asn Glu 
             100



<210> 2673
<211> 2528
<212> DNA
<213> Rattus norvegicus
<308> K00750
<400> 2673

gctcctccc  aacacgcag  ccggagggt  acgtcatcc  cgtccacgc  ttacgtcca  60
gggcctgtc  taagtgtcg  gcaaacgag  cctctagag  aagggcgcc  tctcggtac  120
acctaccat  ctagcccgc  tgcgcgcgc  ccttgctag  gctcccaat  ctggagcca  180
tgacatgcg  ctacgtcac  gcgcagtgc  cggcgctgc  gcacgtccg  ccgcgggag  240
gcagaacaa  tgtggttgc  ttgacaccg  tacataggc  cgggccggc  tgtccttgg  300
ctagagagc  ggacgtctc  ctaagagtc  gatcctttg  ggtgttgac  agcccggac  360
ggtgagcgc  cgacgggga  gcggggcgg  agagggcga  gagaccgag  caggcctga  420
ctacaaaga  atgcggaac  gtggaggct  cgtgggtga  gggctgggg  cagagttct  480
gagggagct  gcccgccgc  ccttctgag  gcagaagct  ctgtttctt  agaactggg  540
tggttcttt  tctgattaa  tttctggaa  ggtgggttt  ttcagtccc  tttggatga  600
ctcgtggtt  cccctggga  ctcagaacg  gtagagtga  aaggttcct  cccttgcct  660
cccgggccg  actaatgca  gagtgactt  acctccaaa  gagaccaga  caggaggag  720
aagcactta  gatcttcag  ccccgagcc  cattgatgt  ttttccctt  tctttggaa  780
tgactttaa  tgacagcac  gacagcaat  aagcattct  aaatgctaa  aggtatagt  840
gttttggct  aacaaaatt  tagtctagt  tcatatttg  ctttttgac  ttgccttct  900
cagaaactg  agcttgaac  gtgggtttc  atttccctt  cttgggcat  agcctgtct  960
gaaagtttg  tttaatcct  aataacgcg  ttgctgttg  aggatattg  aaacagact  1020
agttattag  tagcatcca  cctggtggt  gtattgtaa  gggttggta  ttaagtgat  1080
tgagtggtc  ttgggatcc  tagtatgtt  tgctgtaac  agtgacttg  accgttggg  1140
ctttttcat  tctagaatt  aaaatgggt  atgttgaaa  aggcaagaa  atttttgtt  1200
aaaagtgtg  ccagtgcca  actgtggaa  aaggaggca  gcataagac  ggaccaaac  1260
tccatggtc  gtttgggcg  aagacaggc  aggctgctg  attctctta  acagatgcc  1320
acaagaaca  aggtaagtg  ggagctgct  ttcagacag  gcacaggtt  catgggtgt  1380
accaatgca  acttatcag  tataaaaca  ttaactgct  catctcttt  tgtgtaggt  1440
tcacctggg  agaggatac  ctgatggag  atttggaaa  tcccaaaaa  tacatccct  1500
gaacaaaaa  gatcttcgc  ggaattaag  agaagggag  aagggcaga  ctaatagct  1560
atcttaaaa  ggctactaa  gaataattc  actgcctta  ttattacaa  acaaatgtc  1620
catggcttt  aatgtatac  ataatttaa  tcatacacc  aattcagat  atgaatggc  1680
aacaatgtt  ttgttggac  gccccgatt  aagtaaaat  gacttgtca  aaagtggat  1740
tgatctttt  taaagtaac  cttccaatt  aatacatgt  atcactgct  tccctttct  1800
aagataaga  tggacttaa  tagtaatat  ttcctttcc  taaatagga  ggtgtcgcc  1860
caaacctat  gaatggttt  atacttaga  ttatataac  gggtatatg  atatgttca  1920
atcctggga  aattctgtc  ctgtctgag  aacaagaag  ctcacccgt  cttcagtgt  1980
tgtaaactg  cctctgaca  gcaatgcta  acaccagga  ggaactatt  ttgacagtg  2040
tgttttaat  agaattccc  acatcaatg  tgctgcctt  caccactga  aggcattta  2100
tgtggttta  gtatgatat  aaataaaga  tatttaaca  ttctttata  ttgatctac  2160
agttaaaat  cttttaaga  caagttagg  cttttaaat  ttctcttat  taagactaa  2220
ctgtaattc  gaattgtcc  taaatgccc  ttcggaaag  cataactgg  atttctgtt  2280
atgcctgat  gggagtggt  ctcttttct  acttactag  tggaaagat  aaaataaag  2340
agataattt  taagttatc  acagtcaga  gataattaa  tcaatcaca  atcatgatc  2400
tttgattgt  ctttaatga  ggttggcaa  acttaagct  tttaaactt  ccctagtaa  2460
accgtggtc  agtgaaagc  ctggttgat  ttaccttga  acggggaca  ctcagacta  2520
agcaacac  2528



<210> 2674
<211> 104
<212> PRT
<213> Rattus norvegicus
<308> AAA21711
<400> 2674

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Val Gln Lys Cys Ala Gln 
  1               5                  10                  15
Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
             20                  25                  30
His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Ala Gly Phe Ser Tyr 
         35                  40                  45
Thr Asp Ala Asn Lys Asn Lys Gly Ile Thr Trp Gly Glu Asp Thr Leu 
     50                  55                  60
Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
 65                  70                  75                  80
Ile Phe Ala Gly Ile Lys Lys Lys Gly Glu Arg Ala Asp Leu Ile Ala 
                 85                  90                  95
Tyr Leu Lys Lys Ala Thr Asn Glu 
             100



<210> 2675
<211> 3990
<212> DNA
<213> Homo sapiens
<308> NM_018947
<400> 2675

ggacgtccg  cttcggagc  ggagtgttc  ttgtgccag  gactaaaaa  agaattaaa  60
atgggtgat  ttgagaaag  caagaagat  tttattatg  agtgttccc  gtgccacac  120
gttgaaaag  gaggcaagc  caagactgg  ccaaatctc  atggtctct  tgggcggaa  180
acaggtcag  cccctggat  ctcttacac  gccgccaat  agaacaaag  catcatctg  240
ggagaggat  cactgatgg  gtatttgga  aatcccaag  agtacatcc  tggaacaaa  300
atgatcttt  tcggcatta  gaagaagga  gaaagggca  acttaatag  ttatctcaa  360
aaagctact  atgagtaat  attggccac  gccttattt  ttacaaaac  gaaatgtct  420
atgactttt  tatgtgtac  atcctttaa  agatctcat  caccagaat  cagatcatg  480
atgactgac  gaatatttt  ttgggcagt  ctgatttaa  actaagact  gcttgtggt  540
aaatgaata  gttcagttt  tgaatttta  tagtaactc  aattcagta  atggtatca  600
tgtttaccc  ttttaaaga  atgattaga  ttcgttagt  atgttcaac  tttcacaaa  660
atggtgagt  ccatcttaa  acttactgg  gattggttt  atatttaga  ttatataac  720
ggttatgtg  atatattta  atactgggg  aattgcttc  ctgtcttag  accaagcaa  780
attcacctg  gttttgtgt  catgttcat  tgcctctta  aggcaaggg  tgaagataa  840
taaggttgc  atgtctata  ttttggcct  aactatgcc  atctaatta  aattccctg  900
atttaaaat  gtttctttt  cttattgaa  ggcatttta  tgtggttta  gtgtaatat  960
aaagattat  caacacctc  cacatctta  agatctata  ggtcacatg  ttttaaaat  1020
gtagcaagt  aaacttcac  cttgaattc  ttacaatct  agtcaaact  agttataat  1080
taggattgt  tttaaacag  cattcagaa  caaaactgt  gaactgtgt  tttgattgg  1140
aatggtgct  ttgccaact  aaaaggatt  aagtaacgg  gatatacac  aattttaaa  1200
ttatgtgtg  tcacaagac  aaagataat  aaaaagaaa  ccacagatc  tgacttttt  1260
actgtgctt  atttcatga  tgatgcaca  attttaatg  ttaaaaagt  caggagccc  1320
aaatgtcag  gcagcagcc  taaatgtca  tgcagcagt  ttaaccagt  atggtgcta  1380
attgtttac  tggttttct  ggactgcct  aactagaat  acacttcac  aattgactc  1440
tagtttctt  gctcagatt  agaactgca  catttatgc  agacatgga  agaggaatg  1500
ctgtggtca  agttttgtg  tgtgtaaca  tgtataatt  catactgaa  tatttcatg  1560
atagtctgt  ccatacaca  ttagagtag  ccttggaga  tttatggag  tggtgagca  1620
aaggtaagt  ataaagaat  atgagaaaa  aaatctatg  tggtgcagc  gagaactgt  1680
tctttgtgg  acagtgaga  gactgagaa  atgtgaatc  atggtctca  aggtgatag  1740
gacgattag  taggtgttt  aaggcctga  agcaattta  aacatatga  tcttatttt  1800
atttataga  atgtggaaa  cttgctgta  ttcatattt  aagtcctag  ctgagttct  1860
gtggggaat  taaaaatgc  tcctggaaa  cctttaaag  tttcagact  tgaaaggcc  1920
tgtagcaga  gacttggtg  ctgtataaa  ttagtggta  tcagggaca  tgtagcaag  1980
agcttacaa  gggacaatt  tggactaat  agaaagacc  gaagtgaag  ctagagagt  2040
gattttttt  ttttttggc  tcctggaaa  gatacagga  acatattaa  atagataca  2100
aaatgtgtt  aaccttcca  cttggctag  tgtggcgtt  agtttgttt  ttgagacat  2160
gtcacgctg  gtcgccaag  ctggagtgc  gtggtgcga  ctcggctgg  tgcagcctc  2220
atttcccag  ctcaagcga  tctctcact  cagcttccc  agtagctgg  actgcgggt  2280
ttcgccacc  tgcccagct  atttttttg  agagatgga  ttttgccat  tggtcccag  2340
ctggtctca  actcctgag  tcaagcaat  cgtccactt  ccttggctc  ccaaagtgc  2400
gggattgca  gcgtgagcc  ccaggccct  cctggtttt  aaattcaga  atcttatta  2460
ttaacccag  agtaatcag  ccagtagta  cttaggttt  atttttttt  aggtttaaa  2520
tttttctca  ttatttttt  tgagacgga  tttcgccct  ttcgcccag  ctgagtaca  2580
tggtgcaat  tcactgcaa  ctccgcctt  cagttgcaa  tgattctcc  gcctcagcc  2640
cctgagtag  tgggattgc  ggcacccgc  accacgcct  gctaatttt  gtattttta  2700
tggagatgg  gtttcacca  gttggccag  ctggtcttg  actcctgac  tcgtgatcc  2760
cccaccttg  cctcccaaa  ttctaggat  acaggtgtg  gccaccacg  ccggccaat  2820
tttctcatt  ctatgcctc  tatattaag  tctgtgttg  cacagatga  taactgcca  2880
gttctaggt  agttatacc  aagcacttc  ggtggttta  aatgtgatt  tgtaacttt  2940
ttattttta  ttttttgag  taatttcac  cttgttgcc  aggctggag  gcaatggcg  3000
gatcgctgc  caccgcaac  tccgccttc  aggttcaag  gattctcct  actcagcct  3060
tcaagtagc  gggattaca  gcatgcgcc  ccatgccca  cttattttg  gtttttagt  3120
gagacaggg  ttctccatg  tggacaggc  ggtcttgaa  tcccgacgt  gggtgatct  3180
cctgcctcg  cctcccaaa  tgctgggat  acaggcgtg  gccaccacg  ctggccaat  3240
atgtaattt  ttaaaaagg  catttctat  agggatata  accttcaga  ataaggaaa  3300
aggggaaaa  aagagcact  taaaccaca  gttttcatt  ctagtgctt  gctgtaagt  3360
gctaggttg  tagaatcaa  aacaagggc  agatgtatt  aaggggtat  cagatgcca  3420
ctacatgct  attttgtct  gaacagtgc  gtctaatag  actttctgt  acgatggat  3480
ttttgtaga  ttttgctgt  cagtgtggt  gccactaac  acatgtggc  gttaagccc  3540
tgaaatata  ctagtgtga  tagaaagta  tttatttta  atttacata  gcacaagtg  3600
ctagtggct  ctgtattga  attctgggt  taggactag  accagtggt  tgtaacaaa  3660
gtactttct  tttactcta  taaatctag  attagccgg  catggtcgc  catgcctgt  3720
gtcccagca  tttgggagg  caaggcagg  agatcactt  aggtcgggc  tttgagacc  3780
gcctggtca  catggcgaa  ccctgtctc  acaaaaaac  taaaagtta  ccaggtgtg  3840
tggtgggca  ctgtagtct  agctacttg  gaggctgag  cacaagaat  acttgaact  3900
gggaggtgg  ggttgcagt  agccaggat  gtgccactg  actcaagcc  gggtgacga  3960
tgaaactgt  tccaaaaaa  aaaaaaaaaa  3990



<210> 2676
<211> 104
<212> PRT
<213> Homo sapiens
<308> P00001
<400> 2676

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser Gln 
  1               5                  10                  15
Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
             20                  25                  30
His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Pro Gly Tyr Ser Tyr 
         35                  40                  45
Thr Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Thr Leu 
     50                  55                  60
Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
 65                  70                  75                  80
Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile Ala 
                 85                  90                  95
Tyr Leu Lys Lys Ala Thr Asn Glu 
             100



<210> 2677
<211> 2528
<212> DNA
<213> Rattus norvegicus
<308> K00750
<400> 2677

gctcctccc  aacacgcag  ccggagggt  acgtcatcc  cgtccacgc  ttacgtcca  60
gggcctgtc  taagtgtcg  gcaaacgag  cctctagag  aagggcgcc  tctcggtac  120
acctaccat  ctagcccgc  tgcgcgcgc  ccttgctag  gctcccaat  ctggagcca  180
tgacatgcg  ctacgtcac  gcgcagtgc  cggcgctgc  gcacgtccg  ccgcgggag  240
gcagaacaa  tgtggttgc  ttgacaccg  tacataggc  cgggccggc  tgtccttgg  300
ctagagagc  ggacgtctc  ctaagagtc  gatcctttg  ggtgttgac  agcccggac  360
ggtgagcgc  cgacgggga  gcggggcgg  agagggcga  gagaccgag  caggcctga  420
ctacaaaga  atgcggaac  gtggaggct  cgtgggtga  gggctgggg  cagagttct  480
gagggagct  gcccgccgc  ccttctgag  gcagaagct  ctgtttctt  agaactggg  540
tggttcttt  tctgattaa  tttctggaa  ggtgggttt  ttcagtccc  tttggatga  600
ctcgtggtt  cccctggga  ctcagaacg  gtagagtga  aaggttcct  cccttgcct  660
cccgggccg  actaatgca  gagtgactt  acctccaaa  gagaccaga  caggaggag  720
aagcactta  gatcttcag  ccccgagcc  cattgatgt  ttttccctt  tctttggaa  780
tgactttaa  tgacagcac  gacagcaat  aagcattct  aaatgctaa  aggtatagt  840
gttttggct  aacaaaatt  tagtctagt  tcatatttg  ctttttgac  ttgccttct  900
cagaaactg  agcttgaac  gtgggtttc  atttccctt  cttgggcat  agcctgtct  960
gaaagtttg  tttaatcct  aataacgcg  ttgctgttg  aggatattg  aaacagact  1020
agttattag  tagcatcca  cctggtggt  gtattgtaa  gggttggta  ttaagtgat  1080
tgagtggtc  ttgggatcc  tagtatgtt  tgctgtaac  agtgacttg  accgttggg  1140
ctttttcat  tctagaatt  aaaatgggt  atgttgaaa  aggcaagaa  atttttgtt  1200
aaaagtgtg  ccagtgcca  actgtggaa  aaggaggca  gcataagac  ggaccaaac  1260
tccatggtc  gtttgggcg  aagacaggc  aggctgctg  attctctta  acagatgcc  1320
acaagaaca  aggtaagtg  ggagctgct  ttcagacag  gcacaggtt  catgggtgt  1380
accaatgca  acttatcag  tataaaaca  ttaactgct  catctcttt  tgtgtaggt  1440
tcacctggg  agaggatac  ctgatggag  atttggaaa  tcccaaaaa  tacatccct  1500
gaacaaaaa  gatcttcgc  ggaattaag  agaagggag  aagggcaga  ctaatagct  1560
atcttaaaa  ggctactaa  gaataattc  actgcctta  ttattacaa  acaaatgtc  1620
catggcttt  aatgtatac  ataatttaa  tcatacacc  aattcagat  atgaatggc  1680
aacaatgtt  ttgttggac  gccccgatt  aagtaaaat  gacttgtca  aaagtggat  1740
tgatctttt  taaagtaac  cttccaatt  aatacatgt  atcactgct  tccctttct  1800
aagataaga  tggacttaa  tagtaatat  ttcctttcc  taaatagga  ggtgtcgcc  1860
caaacctat  gaatggttt  atacttaga  ttatataac  gggtatatg  atatgttca  1920
atcctggga  aattctgtc  ctgtctgag  aacaagaag  ctcacccgt  cttcagtgt  1980
tgtaaactg  cctctgaca  gcaatgcta  acaccagga  ggaactatt  ttgacagtg  2040
tgttttaat  agaattccc  acatcaatg  tgctgcctt  caccactga  aggcattta  2100
tgtggttta  gtatgatat  aaataaaga  tatttaaca  ttctttata  ttgatctac  2160
agttaaaat  cttttaaga  caagttagg  cttttaaat  ttctcttat  taagactaa  2220
ctgtaattc  gaattgtcc  taaatgccc  ttcggaaag  cataactgg  atttctgtt  2280
atgcctgat  gggagtggt  ctcttttct  acttactag  tggaaagat  aaaataaag  2340
agataattt  taagttatc  acagtcaga  gataattaa  tcaatcaca  atcatgatc  2400
tttgattgt  ctttaatga  ggttggcaa  acttaagct  tttaaactt  ccctagtaa  2460
accgtggtc  agtgaaagc  ctggttgat  ttaccttga  acggggaca  ctcagacta  2520
agcaacac  2528



<210> 2678
<211> 104
<212> PRT
<213> Rattus norvegicus
<308> AAA21711
<400> 2678

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Val Gln Lys Cys Ala Gln 
  1               5                  10                  15
Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
             20                  25                  30
His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Ala Gly Phe Ser Tyr 
         35                  40                  45
Thr Asp Ala Asn Lys Asn Lys Gly Ile Thr Trp Gly Glu Asp Thr Leu 
     50                  55                  60
Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
 65                  70                  75                  80
Ile Phe Ala Gly Ile Lys Lys Lys Gly Glu Arg Ala Asp Leu Ile Ala 
                 85                  90                  95
Tyr Leu Lys Lys Ala Thr Asn Glu 
             100



<210> 2679
<211> 3990
<212> DNA
<213> Homo sapiens
<308> NM_018947
<400> 2679

ggacgtccg  cttcggagc  ggagtgttc  ttgtgccag  gactaaaaa  agaattaaa  60
atgggtgat  ttgagaaag  caagaagat  tttattatg  agtgttccc  gtgccacac  120
gttgaaaag  gaggcaagc  caagactgg  ccaaatctc  atggtctct  tgggcggaa  180
acaggtcag  cccctggat  ctcttacac  gccgccaat  agaacaaag  catcatctg  240
ggagaggat  cactgatgg  gtatttgga  aatcccaag  agtacatcc  tggaacaaa  300
atgatcttt  tcggcatta  gaagaagga  gaaagggca  acttaatag  ttatctcaa  360
aaagctact  atgagtaat  attggccac  gccttattt  ttacaaaac  gaaatgtct  420
atgactttt  tatgtgtac  atcctttaa  agatctcat  caccagaat  cagatcatg  480
atgactgac  gaatatttt  ttgggcagt  ctgatttaa  actaagact  gcttgtggt  540
aaatgaata  gttcagttt  tgaatttta  tagtaactc  aattcagta  atggtatca  600
tgtttaccc  ttttaaaga  atgattaga  ttcgttagt  atgttcaac  tttcacaaa  660
atggtgagt  ccatcttaa  acttactgg  gattggttt  atatttaga  ttatataac  720
ggttatgtg  atatattta  atactgggg  aattgcttc  ctgtcttag  accaagcaa  780
attcacctg  gttttgtgt  catgttcat  tgcctctta  aggcaaggg  tgaagataa  840
taaggttgc  atgtctata  ttttggcct  aactatgcc  atctaatta  aattccctg  900
atttaaaat  gtttctttt  cttattgaa  ggcatttta  tgtggttta  gtgtaatat  960
aaagattat  caacacctc  cacatctta  agatctata  ggtcacatg  ttttaaaat  1020
gtagcaagt  aaacttcac  cttgaattc  ttacaatct  agtcaaact  agttataat  1080
taggattgt  tttaaacag  cattcagaa  caaaactgt  gaactgtgt  tttgattgg  1140
aatggtgct  ttgccaact  aaaaggatt  aagtaacgg  gatatacac  aattttaaa  1200
ttatgtgtg  tcacaagac  aaagataat  aaaaagaaa  ccacagatc  tgacttttt  1260
actgtgctt  atttcatga  tgatgcaca  attttaatg  ttaaaaagt  caggagccc  1320
aaatgtcag  gcagcagcc  taaatgtca  tgcagcagt  ttaaccagt  atggtgcta  1380
attgtttac  tggttttct  ggactgcct  aactagaat  acacttcac  aattgactc  1440
tagtttctt  gctcagatt  agaactgca  catttatgc  agacatgga  agaggaatg  1500
ctgtggtca  agttttgtg  tgtgtaaca  tgtataatt  catactgaa  tatttcatg  1560
atagtctgt  ccatacaca  ttagagtag  ccttggaga  tttatggag  tggtgagca  1620
aaggtaagt  ataaagaat  atgagaaaa  aaatctatg  tggtgcagc  gagaactgt  1680
tctttgtgg  acagtgaga  gactgagaa  atgtgaatc  atggtctca  aggtgatag  1740
gacgattag  taggtgttt  aaggcctga  agcaattta  aacatatga  tcttatttt  1800
atttataga  atgtggaaa  cttgctgta  ttcatattt  aagtcctag  ctgagttct  1860
gtggggaat  taaaaatgc  tcctggaaa  cctttaaag  tttcagact  tgaaaggcc  1920
tgtagcaga  gacttggtg  ctgtataaa  ttagtggta  tcagggaca  tgtagcaag  1980
agcttacaa  gggacaatt  tggactaat  agaaagacc  gaagtgaag  ctagagagt  2040
gattttttt  ttttttggc  tcctggaaa  gatacagga  acatattaa  atagataca  2100
aaatgtgtt  aaccttcca  cttggctag  tgtggcgtt  agtttgttt  ttgagacat  2160
gtcacgctg  gtcgccaag  ctggagtgc  gtggtgcga  ctcggctgg  tgcagcctc  2220
atttcccag  ctcaagcga  tctctcact  cagcttccc  agtagctgg  actgcgggt  2280
ttcgccacc  tgcccagct  atttttttg  agagatgga  ttttgccat  tggtcccag  2340
ctggtctca  actcctgag  tcaagcaat  cgtccactt  ccttggctc  ccaaagtgc  2400
gggattgca  gcgtgagcc  ccaggccct  cctggtttt  aaattcaga  atcttatta  2460
ttaacccag  agtaatcag  ccagtagta  cttaggttt  atttttttt  aggtttaaa  2520
tttttctca  ttatttttt  tgagacgga  tttcgccct  ttcgcccag  ctgagtaca  2580
tggtgcaat  tcactgcaa  ctccgcctt  cagttgcaa  tgattctcc  gcctcagcc  2640
cctgagtag  tgggattgc  ggcacccgc  accacgcct  gctaatttt  gtattttta  2700
tggagatgg  gtttcacca  gttggccag  ctggtcttg  actcctgac  tcgtgatcc  2760
cccaccttg  cctcccaaa  ttctaggat  acaggtgtg  gccaccacg  ccggccaat  2820
tttctcatt  ctatgcctc  tatattaag  tctgtgttg  cacagatga  taactgcca  2880
gttctaggt  agttatacc  aagcacttc  ggtggttta  aatgtgatt  tgtaacttt  2940
ttattttta  ttttttgag  taatttcac  cttgttgcc  aggctggag  gcaatggcg  3000
gatcgctgc  caccgcaac  tccgccttc  aggttcaag  gattctcct  actcagcct  3060
tcaagtagc  gggattaca  gcatgcgcc  ccatgccca  cttattttg  gtttttagt  3120
gagacaggg  ttctccatg  tggacaggc  ggtcttgaa  tcccgacgt  gggtgatct  3180
cctgcctcg  cctcccaaa  tgctgggat  acaggcgtg  gccaccacg  ctggccaat  3240
atgtaattt  ttaaaaagg  catttctat  agggatata  accttcaga  ataaggaaa  3300
aggggaaaa  aagagcact  taaaccaca  gttttcatt  ctagtgctt  gctgtaagt  3360
gctaggttg  tagaatcaa  aacaagggc  agatgtatt  aaggggtat  cagatgcca  3420
ctacatgct  attttgtct  gaacagtgc  gtctaatag  actttctgt  acgatggat  3480
ttttgtaga  ttttgctgt  cagtgtggt  gccactaac  acatgtggc  gttaagccc  3540
tgaaatata  ctagtgtga  tagaaagta  tttatttta  atttacata  gcacaagtg  3600
ctagtggct  ctgtattga  attctgggt  taggactag  accagtggt  tgtaacaaa  3660
gtactttct  tttactcta  taaatctag  attagccgg  catggtcgc  catgcctgt  3720
gtcccagca  tttgggagg  caaggcagg  agatcactt  aggtcgggc  tttgagacc  3780
gcctggtca  catggcgaa  ccctgtctc  acaaaaaac  taaaagtta  ccaggtgtg  3840
tggtgggca  ctgtagtct  agctacttg  gaggctgag  cacaagaat  acttgaact  3900
gggaggtgg  ggttgcagt  agccaggat  gtgccactg  actcaagcc  gggtgacga  3960
tgaaactgt  tccaaaaaa  aaaaaaaaaa  3990



<210> 2680
<211> 104
<212> PRT
<213> Homo sapiens
<308> P00001
<400> 2680

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser Gln 
  1               5                  10                  15
Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
             20                  25                  30
His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Pro Gly Tyr Ser Tyr 
         35                  40                  45
Thr Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Thr Leu 
     50                  55                  60
Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
 65                  70                  75                  80
Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile Ala 
                 85                  90                  95
Tyr Leu Lys Lys Ala Thr Asn Glu 
             100



<210> 2681
<211> 2528
<212> DNA
<213> Rattus norvegicus
<308> K00750
<400> 2681

gctcctccc  aacacgcag  ccggagggt  acgtcatcc  cgtccacgc  ttacgtcca  60
gggcctgtc  taagtgtcg  gcaaacgag  cctctagag  aagggcgcc  tctcggtac  120
acctaccat  ctagcccgc  tgcgcgcgc  ccttgctag  gctcccaat  ctggagcca  180
tgacatgcg  ctacgtcac  gcgcagtgc  cggcgctgc  gcacgtccg  ccgcgggag  240
gcagaacaa  tgtggttgc  ttgacaccg  tacataggc  cgggccggc  tgtccttgg  300
ctagagagc  ggacgtctc  ctaagagtc  gatcctttg  ggtgttgac  agcccggac  360
ggtgagcgc  cgacgggga  gcggggcgg  agagggcga  gagaccgag  caggcctga  420
ctacaaaga  atgcggaac  gtggaggct  cgtgggtga  gggctgggg  cagagttct  480
gagggagct  gcccgccgc  ccttctgag  gcagaagct  ctgtttctt  agaactggg  540
tggttcttt  tctgattaa  tttctggaa  ggtgggttt  ttcagtccc  tttggatga  600
ctcgtggtt  cccctggga  ctcagaacg  gtagagtga  aaggttcct  cccttgcct  660
cccgggccg  actaatgca  gagtgactt  acctccaaa  gagaccaga  caggaggag  720
aagcactta  gatcttcag  ccccgagcc  cattgatgt  ttttccctt  tctttggaa  780
tgactttaa  tgacagcac  gacagcaat  aagcattct  aaatgctaa  aggtatagt  840
gttttggct  aacaaaatt  tagtctagt  tcatatttg  ctttttgac  ttgccttct  900
cagaaactg  agcttgaac  gtgggtttc  atttccctt  cttgggcat  agcctgtct  960
gaaagtttg  tttaatcct  aataacgcg  ttgctgttg  aggatattg  aaacagact  1020
agttattag  tagcatcca  cctggtggt  gtattgtaa  gggttggta  ttaagtgat  1080
tgagtggtc  ttgggatcc  tagtatgtt  tgctgtaac  agtgacttg  accgttggg  1140
ctttttcat  tctagaatt  aaaatgggt  atgttgaaa  aggcaagaa  atttttgtt  1200
aaaagtgtg  ccagtgcca  actgtggaa  aaggaggca  gcataagac  ggaccaaac  1260
tccatggtc  gtttgggcg  aagacaggc  aggctgctg  attctctta  acagatgcc  1320
acaagaaca  aggtaagtg  ggagctgct  ttcagacag  gcacaggtt  catgggtgt  1380
accaatgca  acttatcag  tataaaaca  ttaactgct  catctcttt  tgtgtaggt  1440
tcacctggg  agaggatac  ctgatggag  atttggaaa  tcccaaaaa  tacatccct  1500
gaacaaaaa  gatcttcgc  ggaattaag  agaagggag  aagggcaga  ctaatagct  1560
atcttaaaa  ggctactaa  gaataattc  actgcctta  ttattacaa  acaaatgtc  1620
catggcttt  aatgtatac  ataatttaa  tcatacacc  aattcagat  atgaatggc  1680
aacaatgtt  ttgttggac  gccccgatt  aagtaaaat  gacttgtca  aaagtggat  1740
tgatctttt  taaagtaac  cttccaatt  aatacatgt  atcactgct  tccctttct  1800
aagataaga  tggacttaa  tagtaatat  ttcctttcc  taaatagga  ggtgtcgcc  1860
caaacctat  gaatggttt  atacttaga  ttatataac  gggtatatg  atatgttca  1920
atcctggga  aattctgtc  ctgtctgag  aacaagaag  ctcacccgt  cttcagtgt  1980
tgtaaactg  cctctgaca  gcaatgcta  acaccagga  ggaactatt  ttgacagtg  2040
tgttttaat  agaattccc  acatcaatg  tgctgcctt  caccactga  aggcattta  2100
tgtggttta  gtatgatat  aaataaaga  tatttaaca  ttctttata  ttgatctac  2160
agttaaaat  cttttaaga  caagttagg  cttttaaat  ttctcttat  taagactaa  2220
ctgtaattc  gaattgtcc  taaatgccc  ttcggaaag  cataactgg  atttctgtt  2280
atgcctgat  gggagtggt  ctcttttct  acttactag  tggaaagat  aaaataaag  2340
agataattt  taagttatc  acagtcaga  gataattaa  tcaatcaca  atcatgatc  2400
tttgattgt  ctttaatga  ggttggcaa  acttaagct  tttaaactt  ccctagtaa  2460
accgtggtc  agtgaaagc  ctggttgat  ttaccttga  acggggaca  ctcagacta  2520
agcaacac  2528



<210> 2682
<211> 104
<212> PRT
<213> Rattus norvegicus
<308> AAA21711
<400> 2682

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Val Gln Lys Cys Ala Gln 
  1               5                  10                  15
Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
             20                  25                  30
His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Ala Gly Phe Ser Tyr 
         35                  40                  45
Thr Asp Ala Asn Lys Asn Lys Gly Ile Thr Trp Gly Glu Asp Thr Leu 
     50                  55                  60
Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
 65                  70                  75                  80
Ile Phe Ala Gly Ile Lys Lys Lys Gly Glu Arg Ala Asp Leu Ile Ala 
                 85                  90                  95
Tyr Leu Lys Lys Ala Thr Asn Glu 
             100



<210> 2683
<211> 3990
<212> DNA
<213> Homo sapiens
<308> NM_018947
<400> 2683

ggacgtccg  cttcggagc  ggagtgttc  ttgtgccag  gactaaaaa  agaattaaa  60
atgggtgat  ttgagaaag  caagaagat  tttattatg  agtgttccc  gtgccacac  120
gttgaaaag  gaggcaagc  caagactgg  ccaaatctc  atggtctct  tgggcggaa  180
acaggtcag  cccctggat  ctcttacac  gccgccaat  agaacaaag  catcatctg  240
ggagaggat  cactgatgg  gtatttgga  aatcccaag  agtacatcc  tggaacaaa  300
atgatcttt  tcggcatta  gaagaagga  gaaagggca  acttaatag  ttatctcaa  360
aaagctact  atgagtaat  attggccac  gccttattt  ttacaaaac  gaaatgtct  420
atgactttt  tatgtgtac  atcctttaa  agatctcat  caccagaat  cagatcatg  480
atgactgac  gaatatttt  ttgggcagt  ctgatttaa  actaagact  gcttgtggt  540
aaatgaata  gttcagttt  tgaatttta  tagtaactc  aattcagta  atggtatca  600
tgtttaccc  ttttaaaga  atgattaga  ttcgttagt  atgttcaac  tttcacaaa  660
atggtgagt  ccatcttaa  acttactgg  gattggttt  atatttaga  ttatataac  720
ggttatgtg  atatattta  atactgggg  aattgcttc  ctgtcttag  accaagcaa  780
attcacctg  gttttgtgt  catgttcat  tgcctctta  aggcaaggg  tgaagataa  840
taaggttgc  atgtctata  ttttggcct  aactatgcc  atctaatta  aattccctg  900
atttaaaat  gtttctttt  cttattgaa  ggcatttta  tgtggttta  gtgtaatat  960
aaagattat  caacacctc  cacatctta  agatctata  ggtcacatg  ttttaaaat  1020
gtagcaagt  aaacttcac  cttgaattc  ttacaatct  agtcaaact  agttataat  1080
taggattgt  tttaaacag  cattcagaa  caaaactgt  gaactgtgt  tttgattgg  1140
aatggtgct  ttgccaact  aaaaggatt  aagtaacgg  gatatacac  aattttaaa  1200
ttatgtgtg  tcacaagac  aaagataat  aaaaagaaa  ccacagatc  tgacttttt  1260
actgtgctt  atttcatga  tgatgcaca  attttaatg  ttaaaaagt  caggagccc  1320
aaatgtcag  gcagcagcc  taaatgtca  tgcagcagt  ttaaccagt  atggtgcta  1380
attgtttac  tggttttct  ggactgcct  aactagaat  acacttcac  aattgactc  1440
tagtttctt  gctcagatt  agaactgca  catttatgc  agacatgga  agaggaatg  1500
ctgtggtca  agttttgtg  tgtgtaaca  tgtataatt  catactgaa  tatttcatg  1560
atagtctgt  ccatacaca  ttagagtag  ccttggaga  tttatggag  tggtgagca  1620
aaggtaagt  ataaagaat  atgagaaaa  aaatctatg  tggtgcagc  gagaactgt  1680
tctttgtgg  acagtgaga  gactgagaa  atgtgaatc  atggtctca  aggtgatag  1740
gacgattag  taggtgttt  aaggcctga  agcaattta  aacatatga  tcttatttt  1800
atttataga  atgtggaaa  cttgctgta  ttcatattt  aagtcctag  ctgagttct  1860
gtggggaat  taaaaatgc  tcctggaaa  cctttaaag  tttcagact  tgaaaggcc  1920
tgtagcaga  gacttggtg  ctgtataaa  ttagtggta  tcagggaca  tgtagcaag  1980
agcttacaa  gggacaatt  tggactaat  agaaagacc  gaagtgaag  ctagagagt  2040
gattttttt  ttttttggc  tcctggaaa  gatacagga  acatattaa  atagataca  2100
aaatgtgtt  aaccttcca  cttggctag  tgtggcgtt  agtttgttt  ttgagacat  2160
gtcacgctg  gtcgccaag  ctggagtgc  gtggtgcga  ctcggctgg  tgcagcctc  2220
atttcccag  ctcaagcga  tctctcact  cagcttccc  agtagctgg  actgcgggt  2280
ttcgccacc  tgcccagct  atttttttg  agagatgga  ttttgccat  tggtcccag  2340
ctggtctca  actcctgag  tcaagcaat  cgtccactt  ccttggctc  ccaaagtgc  2400
gggattgca  gcgtgagcc  ccaggccct  cctggtttt  aaattcaga  atcttatta  2460
ttaacccag  agtaatcag  ccagtagta  cttaggttt  atttttttt  aggtttaaa  2520
tttttctca  ttatttttt  tgagacgga  tttcgccct  ttcgcccag  ctgagtaca  2580
tggtgcaat  tcactgcaa  ctccgcctt  cagttgcaa  tgattctcc  gcctcagcc  2640
cctgagtag  tgggattgc  ggcacccgc  accacgcct  gctaatttt  gtattttta  2700
tggagatgg  gtttcacca  gttggccag  ctggtcttg  actcctgac  tcgtgatcc  2760
cccaccttg  cctcccaaa  ttctaggat  acaggtgtg  gccaccacg  ccggccaat  2820
tttctcatt  ctatgcctc  tatattaag  tctgtgttg  cacagatga  taactgcca  2880
gttctaggt  agttatacc  aagcacttc  ggtggttta  aatgtgatt  tgtaacttt  2940
ttattttta  ttttttgag  taatttcac  cttgttgcc  aggctggag  gcaatggcg  3000
gatcgctgc  caccgcaac  tccgccttc  aggttcaag  gattctcct  actcagcct  3060
tcaagtagc  gggattaca  gcatgcgcc  ccatgccca  cttattttg  gtttttagt  3120
gagacaggg  ttctccatg  tggacaggc  ggtcttgaa  tcccgacgt  gggtgatct  3180
cctgcctcg  cctcccaaa  tgctgggat  acaggcgtg  gccaccacg  ctggccaat  3240
atgtaattt  ttaaaaagg  catttctat  agggatata  accttcaga  ataaggaaa  3300
aggggaaaa  aagagcact  taaaccaca  gttttcatt  ctagtgctt  gctgtaagt  3360
gctaggttg  tagaatcaa  aacaagggc  agatgtatt  aaggggtat  cagatgcca  3420
ctacatgct  attttgtct  gaacagtgc  gtctaatag  actttctgt  acgatggat  3480
ttttgtaga  ttttgctgt  cagtgtggt  gccactaac  acatgtggc  gttaagccc  3540
tgaaatata  ctagtgtga  tagaaagta  tttatttta  atttacata  gcacaagtg  3600
ctagtggct  ctgtattga  attctgggt  taggactag  accagtggt  tgtaacaaa  3660
gtactttct  tttactcta  taaatctag  attagccgg  catggtcgc  catgcctgt  3720
gtcccagca  tttgggagg  caaggcagg  agatcactt  aggtcgggc  tttgagacc  3780
gcctggtca  catggcgaa  ccctgtctc  acaaaaaac  taaaagtta  ccaggtgtg  3840
tggtgggca  ctgtagtct  agctacttg  gaggctgag  cacaagaat  acttgaact  3900
gggaggtgg  ggttgcagt  agccaggat  gtgccactg  actcaagcc  gggtgacga  3960
tgaaactgt  tccaaaaaa  aaaaaaaaaa  3990



<210> 2684
<211> 104
<212> PRT
<213> Homo sapiens
<308> P00001
<400> 2684

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser Gln 
  1               5                  10                  15
Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
             20                  25                  30
His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Pro Gly Tyr Ser Tyr 
         35                  40                  45
Thr Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Thr Leu 
     50                  55                  60
Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
 65                  70                  75                  80
Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile Ala 
                 85                  90                  95
Tyr Leu Lys Lys Ala Thr Asn Glu 
             100



<210> 2685
<211> 2528
<212> DNA
<213> Rattus norvegicus
<308> K00750
<400> 2685

gctcctccc  aacacgcag  ccggagggt  acgtcatcc  cgtccacgc  ttacgtcca  60
gggcctgtc  taagtgtcg  gcaaacgag  cctctagag  aagggcgcc  tctcggtac  120
acctaccat  ctagcccgc  tgcgcgcgc  ccttgctag  gctcccaat  ctggagcca  180
tgacatgcg  ctacgtcac  gcgcagtgc  cggcgctgc  gcacgtccg  ccgcgggag  240
gcagaacaa  tgtggttgc  ttgacaccg  tacataggc  cgggccggc  tgtccttgg  300
ctagagagc  ggacgtctc  ctaagagtc  gatcctttg  ggtgttgac  agcccggac  360
ggtgagcgc  cgacgggga  gcggggcgg  agagggcga  gagaccgag  caggcctga  420
ctacaaaga  atgcggaac  gtggaggct  cgtgggtga  gggctgggg  cagagttct  480
gagggagct  gcccgccgc  ccttctgag  gcagaagct  ctgtttctt  agaactggg  540
tggttcttt  tctgattaa  tttctggaa  ggtgggttt  ttcagtccc  tttggatga  600
ctcgtggtt  cccctggga  ctcagaacg  gtagagtga  aaggttcct  cccttgcct  660
cccgggccg  actaatgca  gagtgactt  acctccaaa  gagaccaga  caggaggag  720
aagcactta  gatcttcag  ccccgagcc  cattgatgt  ttttccctt  tctttggaa  780
tgactttaa  tgacagcac  gacagcaat  aagcattct  aaatgctaa  aggtatagt  840
gttttggct  aacaaaatt  tagtctagt  tcatatttg  ctttttgac  ttgccttct  900
cagaaactg  agcttgaac  gtgggtttc  atttccctt  cttgggcat  agcctgtct  960
gaaagtttg  tttaatcct  aataacgcg  ttgctgttg  aggatattg  aaacagact  1020
agttattag  tagcatcca  cctggtggt  gtattgtaa  gggttggta  ttaagtgat  1080
tgagtggtc  ttgggatcc  tagtatgtt  tgctgtaac  agtgacttg  accgttggg  1140
ctttttcat  tctagaatt  aaaatgggt  atgttgaaa  aggcaagaa  atttttgtt  1200
aaaagtgtg  ccagtgcca  actgtggaa  aaggaggca  gcataagac  ggaccaaac  1260
tccatggtc  gtttgggcg  aagacaggc  aggctgctg  attctctta  acagatgcc  1320
acaagaaca  aggtaagtg  ggagctgct  ttcagacag  gcacaggtt  catgggtgt  1380
accaatgca  acttatcag  tataaaaca  ttaactgct  catctcttt  tgtgtaggt  1440
tcacctggg  agaggatac  ctgatggag  atttggaaa  tcccaaaaa  tacatccct  1500
gaacaaaaa  gatcttcgc  ggaattaag  agaagggag  aagggcaga  ctaatagct  1560
atcttaaaa  ggctactaa  gaataattc  actgcctta  ttattacaa  acaaatgtc  1620
catggcttt  aatgtatac  ataatttaa  tcatacacc  aattcagat  atgaatggc  1680
aacaatgtt  ttgttggac  gccccgatt  aagtaaaat  gacttgtca  aaagtggat  1740
tgatctttt  taaagtaac  cttccaatt  aatacatgt  atcactgct  tccctttct  1800
aagataaga  tggacttaa  tagtaatat  ttcctttcc  taaatagga  ggtgtcgcc  1860
caaacctat  gaatggttt  atacttaga  ttatataac  gggtatatg  atatgttca  1920
atcctggga  aattctgtc  ctgtctgag  aacaagaag  ctcacccgt  cttcagtgt  1980
tgtaaactg  cctctgaca  gcaatgcta  acaccagga  ggaactatt  ttgacagtg  2040
tgttttaat  agaattccc  acatcaatg  tgctgcctt  caccactga  aggcattta  2100
tgtggttta  gtatgatat  aaataaaga  tatttaaca  ttctttata  ttgatctac  2160
agttaaaat  cttttaaga  caagttagg  cttttaaat  ttctcttat  taagactaa  2220
ctgtaattc  gaattgtcc  taaatgccc  ttcggaaag  cataactgg  atttctgtt  2280
atgcctgat  gggagtggt  ctcttttct  acttactag  tggaaagat  aaaataaag  2340
agataattt  taagttatc  acagtcaga  gataattaa  tcaatcaca  atcatgatc  2400
tttgattgt  ctttaatga  ggttggcaa  acttaagct  tttaaactt  ccctagtaa  2460
accgtggtc  agtgaaagc  ctggttgat  ttaccttga  acggggaca  ctcagacta  2520
agcaacac  2528



<210> 2686
<211> 104
<212> PRT
<213> Rattus norvegicus
<308> AAA21711
<400> 2686

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Val Gln Lys Cys Ala Gln 
  1               5                  10                  15
Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
             20                  25                  30
His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Ala Gly Phe Ser Tyr 
         35                  40                  45
Thr Asp Ala Asn Lys Asn Lys Gly Ile Thr Trp Gly Glu Asp Thr Leu 
     50                  55                  60
Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
 65                  70                  75                  80
Ile Phe Ala Gly Ile Lys Lys Lys Gly Glu Arg Ala Asp Leu Ile Ala 
                 85                  90                  95
Tyr Leu Lys Lys Ala Thr Asn Glu 
             100



<210> 2687
<211> 3990
<212> DNA
<213> Homo sapiens
<308> NM_018947
<400> 2687

ggacgtccg  cttcggagc  ggagtgttc  ttgtgccag  gactaaaaa  agaattaaa  60
atgggtgat  ttgagaaag  caagaagat  tttattatg  agtgttccc  gtgccacac  120
gttgaaaag  gaggcaagc  caagactgg  ccaaatctc  atggtctct  tgggcggaa  180
acaggtcag  cccctggat  ctcttacac  gccgccaat  agaacaaag  catcatctg  240
ggagaggat  cactgatgg  gtatttgga  aatcccaag  agtacatcc  tggaacaaa  300
atgatcttt  tcggcatta  gaagaagga  gaaagggca  acttaatag  ttatctcaa  360
aaagctact  atgagtaat  attggccac  gccttattt  ttacaaaac  gaaatgtct  420
atgactttt  tatgtgtac  atcctttaa  agatctcat  caccagaat  cagatcatg  480
atgactgac  gaatatttt  ttgggcagt  ctgatttaa  actaagact  gcttgtggt  540
aaatgaata  gttcagttt  tgaatttta  tagtaactc  aattcagta  atggtatca  600
tgtttaccc  ttttaaaga  atgattaga  ttcgttagt  atgttcaac  tttcacaaa  660
atggtgagt  ccatcttaa  acttactgg  gattggttt  atatttaga  ttatataac  720
ggttatgtg  atatattta  atactgggg  aattgcttc  ctgtcttag  accaagcaa  780
attcacctg  gttttgtgt  catgttcat  tgcctctta  aggcaaggg  tgaagataa  840
taaggttgc  atgtctata  ttttggcct  aactatgcc  atctaatta  aattccctg  900
atttaaaat  gtttctttt  cttattgaa  ggcatttta  tgtggttta  gtgtaatat  960
aaagattat  caacacctc  cacatctta  agatctata  ggtcacatg  ttttaaaat  1020
gtagcaagt  aaacttcac  cttgaattc  ttacaatct  agtcaaact  agttataat  1080
taggattgt  tttaaacag  cattcagaa  caaaactgt  gaactgtgt  tttgattgg  1140
aatggtgct  ttgccaact  aaaaggatt  aagtaacgg  gatatacac  aattttaaa  1200
ttatgtgtg  tcacaagac  aaagataat  aaaaagaaa  ccacagatc  tgacttttt  1260
actgtgctt  atttcatga  tgatgcaca  attttaatg  ttaaaaagt  caggagccc  1320
aaatgtcag  gcagcagcc  taaatgtca  tgcagcagt  ttaaccagt  atggtgcta  1380
attgtttac  tggttttct  ggactgcct  aactagaat  acacttcac  aattgactc  1440
tagtttctt  gctcagatt  agaactgca  catttatgc  agacatgga  agaggaatg  1500
ctgtggtca  agttttgtg  tgtgtaaca  tgtataatt  catactgaa  tatttcatg  1560
atagtctgt  ccatacaca  ttagagtag  ccttggaga  tttatggag  tggtgagca  1620
aaggtaagt  ataaagaat  atgagaaaa  aaatctatg  tggtgcagc  gagaactgt  1680
tctttgtgg  acagtgaga  gactgagaa  atgtgaatc  atggtctca  aggtgatag  1740
gacgattag  taggtgttt  aaggcctga  agcaattta  aacatatga  tcttatttt  1800
atttataga  atgtggaaa  cttgctgta  ttcatattt  aagtcctag  ctgagttct  1860
gtggggaat  taaaaatgc  tcctggaaa  cctttaaag  tttcagact  tgaaaggcc  1920
tgtagcaga  gacttggtg  ctgtataaa  ttagtggta  tcagggaca  tgtagcaag  1980
agcttacaa  gggacaatt  tggactaat  agaaagacc  gaagtgaag  ctagagagt  2040
gattttttt  ttttttggc  tcctggaaa  gatacagga  acatattaa  atagataca  2100
aaatgtgtt  aaccttcca  cttggctag  tgtggcgtt  agtttgttt  ttgagacat  2160
gtcacgctg  gtcgccaag  ctggagtgc  gtggtgcga  ctcggctgg  tgcagcctc  2220
atttcccag  ctcaagcga  tctctcact  cagcttccc  agtagctgg  actgcgggt  2280
ttcgccacc  tgcccagct  atttttttg  agagatgga  ttttgccat  tggtcccag  2340
ctggtctca  actcctgag  tcaagcaat  cgtccactt  ccttggctc  ccaaagtgc  2400
gggattgca  gcgtgagcc  ccaggccct  cctggtttt  aaattcaga  atcttatta  2460
ttaacccag  agtaatcag  ccagtagta  cttaggttt  atttttttt  aggtttaaa  2520
tttttctca  ttatttttt  tgagacgga  tttcgccct  ttcgcccag  ctgagtaca  2580
tggtgcaat  tcactgcaa  ctccgcctt  cagttgcaa  tgattctcc  gcctcagcc  2640
cctgagtag  tgggattgc  ggcacccgc  accacgcct  gctaatttt  gtattttta  2700
tggagatgg  gtttcacca  gttggccag  ctggtcttg  actcctgac  tcgtgatcc  2760
cccaccttg  cctcccaaa  ttctaggat  acaggtgtg  gccaccacg  ccggccaat  2820
tttctcatt  ctatgcctc  tatattaag  tctgtgttg  cacagatga  taactgcca  2880
gttctaggt  agttatacc  aagcacttc  ggtggttta  aatgtgatt  tgtaacttt  2940
ttattttta  ttttttgag  taatttcac  cttgttgcc  aggctggag  gcaatggcg  3000
gatcgctgc  caccgcaac  tccgccttc  aggttcaag  gattctcct  actcagcct  3060
tcaagtagc  gggattaca  gcatgcgcc  ccatgccca  cttattttg  gtttttagt  3120
gagacaggg  ttctccatg  tggacaggc  ggtcttgaa  tcccgacgt  gggtgatct  3180
cctgcctcg  cctcccaaa  tgctgggat  acaggcgtg  gccaccacg  ctggccaat  3240
atgtaattt  ttaaaaagg  catttctat  agggatata  accttcaga  ataaggaaa  3300
aggggaaaa  aagagcact  taaaccaca  gttttcatt  ctagtgctt  gctgtaagt  3360
gctaggttg  tagaatcaa  aacaagggc  agatgtatt  aaggggtat  cagatgcca  3420
ctacatgct  attttgtct  gaacagtgc  gtctaatag  actttctgt  acgatggat  3480
ttttgtaga  ttttgctgt  cagtgtggt  gccactaac  acatgtggc  gttaagccc  3540
tgaaatata  ctagtgtga  tagaaagta  tttatttta  atttacata  gcacaagtg  3600
ctagtggct  ctgtattga  attctgggt  taggactag  accagtggt  tgtaacaaa  3660
gtactttct  tttactcta  taaatctag  attagccgg  catggtcgc  catgcctgt  3720
gtcccagca  tttgggagg  caaggcagg  agatcactt  aggtcgggc  tttgagacc  3780
gcctggtca  catggcgaa  ccctgtctc  acaaaaaac  taaaagtta  ccaggtgtg  3840
tggtgggca  ctgtagtct  agctacttg  gaggctgag  cacaagaat  acttgaact  3900
gggaggtgg  ggttgcagt  agccaggat  gtgccactg  actcaagcc  gggtgacga  3960
tgaaactgt  tccaaaaaa  aaaaaaaaaa  3990



<210> 2688
<211> 104
<212> PRT
<213> Homo sapiens
<308> P00001
<400> 2688

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser Gln 
  1               5                  10                  15
Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
             20                  25                  30
His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Pro Gly Tyr Ser Tyr 
         35                  40                  45
Thr Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Thr Leu 
     50                  55                  60
Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
 65                  70                  75                  80
Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile Ala 
                 85                  90                  95
Tyr Leu Lys Lys Ala Thr Asn Glu 
             100



<210> 2689
<211> 314
<212> DNA
<213> Rattus norvegicus
<308> K00994
<400> 2689

aagagcatt  ttcaaaaat  tgcagccaa  gaaggcgat  caaaccagc  gtccaagga  60
gagctgaag  tgctgattc  gtcagagtt  cccaacctc  tgaaggctt  aagtactct  120
gacaatctc  ttgaagagc  ggataagaa  gatgatgga  aagttagct  tgaagaatt  180
gaagttttc  tcaaaaagt  atcacaatg  agccagaag  aggagctcc  acaccacct  240
ctgattgaa  cctatccaa  cccaaagat  tagctgtga  agcaagata  tgttaataa  300
gcaaattct  agac  314



<210> 2690
<211> 78
<212> PRT
<213> Rattus norvegicus
<308> AAA40843
<400> 2690

Ser Ala Lys Lys Ser Pro Glu Glu Met Lys Ser Ile Phe Gln Lys Tyr 
  1               5                  10                  15
Ala Ala Lys Glu Gly Asp Pro Asn Gln Leu Ser Lys Glu Glu Leu Lys 
             20                  25                  30
Leu Leu Ile Gln Ser Glu Phe Pro Ser Leu Leu Lys Ala Ser Ser Thr 
         35                  40                  45
Leu Asp Asn Leu Phe Lys Glu Leu Asp Lys Asn Gly Asp Gly Glu Val 
     50                  55                  60
Ser Tyr Glu Glu Phe Glu Val Phe Phe Lys Lys Leu Ser Gln 
 65                  70                  75



<210> 2691
<211> 456
<212> DNA
<213> Homo sapiens
<308> NM_004057
<400> 2691

aaaaaactc  tctttgatt  ttctagctg  ttcactatt  ggcaaccag  caccagaat  60
agtactaaa  agtctcctg  ggaactgaa  aggattttt  aaaaatatg  agccaaaga  120
ggtgatcca  accagttgt  aaaggatga  ctgaagcta  tgattcagg  tgaattccc  180
agtttactc  aaggtccaa  caccctaga  gatctcttt  aagaactgg  caagaatgg  240
gatggagaa  ttagttttg  agaattcca  gtattagta  aaaagatat  ccagtgaag  300
agaaaacaa  atagaaccc  gagcactgg  ggaagagcg  ctgtgctgt  gtcttatcc  360
atgtggaat  ccccaaagt  tctggttta  ttctttgca  ttataataa  ctggctgtg  420
ggttcagtt  ttattaata  agaaattat  agacat  456



<210> 2692
<211> 78
<212> PRT
<213> Homo sapiens
<308> P29377
<400> 2692

Ser Thr Lys Lys Ser Pro Glu Glu Leu Lys Arg Ile Phe Glu Lys Tyr 
  1               5                  10                  15
Ala Ala Lys Glu Gly Asp Pro Asp Gln Leu Ser Lys Asp Glu Leu Lys 
             20                  25                  30
Leu Leu Ile Gln Ala Glu Phe Pro Ser Leu Leu Lys Gly Pro Asn Thr 
         35                  40                  45
Leu Asp Asp Leu Phe Gln Glu Leu Asp Lys Asn Gly Asp Gly Glu Val 
     50                  55                  60
Ser Phe Glu Glu Phe Gln Val Leu Val Lys Lys Ile Ser Gln 
 65                  70                  75



<210> 2693
<211> 959
<212> DNA
<213> Rattus norvegicus
<308> K01932
<400> 2693

agagggagc  gctttttaa  aagagaact  aagcaattg  tgccatgcc  gggaagcca  60
tccttcact  cttcgatgg  agggggaga  tggagccca  ccggtggct  ctggctgca  120
ctggagtag  gtttgaaga  caatttctg  aaactcggg  tgacctggc  aggctaagg  180
atgatggga  tttgatgtt  cagcaagtg  ccatggtgg  gattgatgg  atgaagctg  240
tgcagacca  agccattct  aactacatt  ccaccaaat  caacctcta  gggaaggac  300
tgaaggaga  agccctcat  gacatgtat  cagaaggag  ggcggatct  gatgaaata  360
ttctccatt  cccttacat  ccccctggg  agaaagagg  aagtcttgc  aaaatcaag  420
acaaagcaa  gaaccgtta  tttcctgcc  ttgaaaagg  gttgaagag  catggacaa  480
attatctcg  tggcaatag  ctgagcagg  ctgatgttt  cctagttca  gttctctac  540
atgtggaag  gctggaccc  agcgctttg  ccaacttcc  tctgctgaa  gccctgaga  600
ccagagtca  caacctccc  acagtgaag  agtttcttc  gcctggcag  cagaggaag  660
cattagagg  tgagaaatg  gtagaatct  cagttaaga  cttcagtta  ttcaggcat  720
tatggatac  ctgtaccca  aaagccagc  ttcgaaagc  ttgcaacaa  cgcatattt  780
gactaaatg  tgaccctac  tattgggag  ccaacacgt  ttctaatgc  tctgtgtta  840
ttcatatag  catgactga  gaggaattg  tgggatgct  tttggttgt  gttaaaatt  900
gaaatcatg  tcacttcct  agatattac  ttgaatctc  ataaaaact  cgcaagctt  959



<210> 2694
<211> 220
<212> PRT
<213> Rattus norvegicus
<308> P04904
<400> 2694

Pro Gly Lys Pro Val Leu His Tyr Phe Asp Gly Arg Gly Arg Met Glu 
  1               5                  10                  15
Pro Ile Arg Trp Leu Leu Ala Ala Ala Gly Val Glu Phe Glu Glu Gln 
             20                  25                  30
Phe Leu Lys Thr Arg Asp Asp Leu Ala Arg Leu Arg Asn Asp Gly Ser 
         35                  40                  45
Leu Met Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys Leu 
     50                  55                  60
Val Gln Thr Arg Ala Ile Leu Asn Tyr Ile Ala Thr Lys Tyr Asn Leu 
 65                  70                  75                  80
Tyr Gly Lys Asp Met Lys Glu Arg Ala Leu Ile Asp Met Tyr Ala Glu 
                 85                  90                  95
Gly Val Ala Asp Leu Asp Glu Ile Val Leu His Tyr Pro Tyr Ile Pro 
             100                105                110
Pro Gly Glu Lys Glu Ala Ser Leu Ala Lys Ile Lys Asp Lys Ala Arg 
         115                120                125
Asn Arg Tyr Phe Pro Ala Phe Glu Lys Val Leu Lys Ser His Gly Gln 
     130                135                140
Asp Tyr Leu Val Gly Asn Arg Leu Ser Arg Ala Asp Val Tyr Leu Val 
 145                150                155                160
Gln Val Leu Tyr His Val Glu Glu Leu Asp Pro Ser Ala Leu Ala Asn 
                 165                170                175
Phe Pro Leu Leu Lys Ala Leu Arg Thr Arg Val Ser Asn Leu Pro Thr 
             180                185                190
Val Lys Lys Phe Leu Gln Pro Gly Ser Gln Arg Lys Pro Leu Glu Asp 
         195                200                205
Glu Lys Cys Val Glu Ser Ala Val Lys Ile Phe Ser 
     210                215                220



<210> 2695
<211> 918
<212> DNA
<213> Homo sapiens
<308> NM_000847
<400> 2695

ggtggcctt  agaagctga  cggagaccg  ctagacttt  ctcaaagaa  ccaagagac  60
gttaccatg  cagggaagc  caagcttca  tacttcaat  gacggggca  aatggagcc  120
atccggtgg  tcttggctg  agctggagt  gagtttgaa  agaaattta  aggatctgc  180
gaagatttg  gaaagttaa  aaatgatgg  agtttgatg  tccagcaag  accaatggt  240
gagattgat  ggattaagt  ggtacagac  agagccatt  tcaactaca  tgccagcaa  300
tacaacctc  acgggaaag  cataaagga  agagcccta  ttgatatgt  tacagaagg  360
atggcagat  tgaatgaaa  gatccttct  ctgccctta  gtcgacctg  ggaaaaaga  420
gccaagatt  ccttgatca  agagaaaac  aaaagtcgc  atttccctg  cttcgaaaa  480
gtgttacag  gccatggac  agactacct  gttggcaac  agctgagcc  ggctgacat  540
agcctggtg  aacttctct  ctatgtgga  gagcttgac  ccagcctta  ctccaactt  600
cctctgctg  aggccctga  aaccagaat  agcaacctg  ccacggtga  gaagtttct  660
cagcctggc  gcccaagga  gcctcccgc  gatgcaaaa  ctttagaag  agccagaaa  720
attttcagg  tttaataaa  cagccatgg  ggctaagaa  atgcaagac  aatattcta  780
agttttgca  caatgaagt  ctttactta  gtgttgatt  tgcctgttg  aaagctaat  840
aaccctttc  aattatatg  taattaaat  ataaaaact  ctatttgca  aaaaaaaaa  900
aaaaaaaaa  aaaaaaaa  918



<210> 2696
<211> 222
<212> PRT
<213> Homo sapiens
<308> Q16772
<400> 2696

Met Ala Gly Lys Pro Lys Leu His Tyr Phe Asn Gly Arg Gly Arg Met 
  1               5                  10                  15
Glu Pro Ile Arg Trp Leu Leu Ala Ala Ala Gly Val Glu Phe Glu Glu 
             20                  25                  30
Lys Phe Ile Gly Ser Ala Glu Asp Leu Gly Lys Leu Arg Asn Asp Gly 
         35                  40                  45
Ser Leu Met Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys 
     50                  55                  60
Leu Val Gln Thr Arg Ala Ile Leu Asn Tyr Ile Ala Ser Lys Tyr Asn 
 65                  70                  75                  80
Leu Tyr Gly Lys Asp Ile Lys Glu Arg Ala Leu Ile Asp Met Tyr Thr 
                 85                  90                  95
Glu Gly Met Ala Asp Leu Asn Glu Met Ile Leu Leu Leu Pro Leu Cys 
             100                105                110
Arg Pro Glu Glu Lys Asp Ala Lys Ile Ala Leu Ile Lys Glu Lys Thr 
         115                120                125
Lys Ser Arg Tyr Phe Pro Ala Phe Glu Lys Val Leu Gln Ser His Gly 
     130                135                140
Gln Asp Tyr Leu Val Gly Asn Lys Leu Ser Arg Ala Asp Ile Ser Leu 
 145                150                155                160
Val Glu Leu Leu Tyr Tyr Val Glu Glu Leu Asp Ser Ser Leu Ile Ser 
                 165                170                175
Asn Phe Pro Leu Leu Lys Ala Leu Lys Thr Arg Ile Ser Asn Leu Pro 
             180                185                190
Thr Val Lys Lys Phe Leu Gln Pro Gly Ser Pro Arg Lys Pro Pro Ala 
         195                200                205
Asp Ala Lys Ala Leu Glu Glu Ala Arg Lys Ile Phe Arg Phe 
     210                215                220



<210> 2697
<211> 2047
<212> DNA
<213> Rattus norvegicus
<308> K02248
<400> 2697

aagcttgat  caagttcag  ggcttatga  ttctgagac  gcttcctag  gctgtttcc  60
ggtgccaaa  gtaggcttt  tcctcctcc  ccctcctgt  tgtgtgtgt  tgtgtgtgt  120
tgtgtgtgt  tgtgtgtgt  tgtgtgtct  tctgtctgt  tgtctgtct  tctgtctgt  180
tccctggtg  ctttctttt  tcacaatat  aagatcagc  gattggaca  agtgatgct  240
ctttatagc  cagtcttat  ctttttcct  caaggcttt  agggatgcc  ggagagaag  300
tagttcagt  ctcctgatt  catattaat  ctcagattg  ttcctagac  gatagcttt  360
agtctccct  gccatacaa  accgttaag  atgatggca  gtccagtaa  ctgagtaca  420
tgacaggta  ccaactgtg  gtgctgatg  attgctggc  aaggactga  ggatctcag  480
aattaatca  gcacctatg  ggcggaaat  tgggatatg  atgtcgaca  tgagtgaag  540
caagattat  tggtctgtg  ggcgtggag  atttcatgt  cctgtgtgg  tgcaggctt  600
ctttttctt  aaaaaaaaa  aaataaacc  ctttagatc  tgtcgcctc  cctcacttc  660
ttgattgat  ttgcgaggc  aatggtgcg  aaaagcact  gtgagatct  ggggcgcct  720
cttggctga  gtcagagag  gagtttaaa  aggggagac  gtggagagc  cgatagcgg  780
tgaaggaga  gctactgga  tcgtctctg  cgcctgcgg  cctgcgtct  gactgaccc  840
ccgcgctca  gctcggctg  ctgaggcag  ggagatgct  tcctgccgt  tccagtgcg  900
gctggccgc  ctctgcatc  tcctggctt  gggcggtgt  accggggcg  cctcggacc  960
cagactccg  cagtttctg  agaagtctc  ggcggctgc  accgggaaa  aggtaagga  1020
atggctggg  ctcgtcccc  ttgcgaatt  cctagcctt  cccttagtc  tgctgtagc  1080
cctgcgaca  gtgttttag  gggcgcttc  cagagtcgc  cagcccctg  gctcccagg  1140
aaacttttg  agtctaggg  ccgctctta  tcgttccag  attgatcgg  gctggtggt  1200
accttgcag  taagttccc  cttcgcttt  aggaaaatt  cgaaagcct  caagagagc  1260
gggagagac  gagctctat  cctggtact  gcacgaggg  tgctgaccc  ggtgctgaa  1320
aaaaatccg  caagaactc  ggtccatgg  ccatttcgt  tctcataaa  gaaaatgga  1380
ctgctcgaa  tattggcat  ctatattta  aaaacgact  cctatcatc  atggtttct  1440
tgtgtttta  ggcatagca  tttctgaaa  acttgggtt  gaggaagct  ttttccctg  1500
gcataatct  gtgaatata  cagccatcc  tattactgt  gaaacttgg  tttgaatga  1560
taaatctta  tttcaaacc  catttctcc  tttctccca  tcccccttt  gctctcctc  1620
ctgccctat  caggaactg  ccaagtact  cttggcaga  ctgctgtcc  agcccaacc  1680
gacagagaa  gatgccctg  agcctgagg  tttgcccca  gcagctgag  aggacgaga  1740
gaggctgga  ctgcagagg  ctgccaact  gaacccagc  atggcaccc  gggaacgca  1800
agctggctg  aagaacttc  tctggaaga  attcacatc  tgttagctt  aatattgtt  1860
tctcagcca  acctctgat  cctctccta  aaatcccat  tctcttcct  aactcccag  1920
ccccccccc  aatgctcaa  tagaccctg  gttagaaac  gaagactgt  aatacaaaa  1980
aaaattatg  tgaaattat  aatagcgag  gtttgactt  ttattgagt  aattgtttt  2040
ttcagga  2047



<210> 2698
<211> 116
<212> PRT
<213> Rattus norvegicus
<308> AAA42161
<400> 2698

Met Leu Ser Cys Arg Leu Gln Cys Ala Leu Ala Ala Leu Cys Ile Val 
  1               5                  10                  15
Leu Ala Leu Gly Gly Val Thr Gly Ala Pro Ser Asp Pro Arg Leu Arg 
             20                  25                  30
Gln Phe Leu Gln Lys Ser Leu Ala Ala Ala Thr Gly Lys Gln Glu Leu 
         35                  40                  45
Ala Lys Tyr Phe Leu Ala Glu Leu Leu Ser Glu Pro Asn Gln Thr Glu 
     50                  55                  60
Asn Asp Ala Leu Glu Pro Glu Asp Leu Pro Gln Ala Ala Glu Gln Asp 
 65                  70                  75                  80
Glu Met Arg Leu Glu Leu Gln Arg Ser Ala Asn Ser Asn Pro Ala Met 
                 85                  90                  95
Ala Pro Arg Glu Arg Lys Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr 
             100                105                110
Phe Thr Ser Cys 
         115



<210> 2699
<211> 351
<212> DNA
<213> Homo sapiens
<308> NM_001048
<400> 2699

atgctgtcc  gccgcctcc  gtgcgcgct  gctgcgctg  ccatcgtcc  ggccctggg  60
tgtgtcacc  gcgctccct  ggaccccag  ctccgtcag  ttctgcaga  gtccctggc  120
gctgccgcg  ggaagcagg  actggccaa  tacttcttg  cagagctgc  gtctgaacc  180
aaccagacg  agaatgatg  cctggaacc  gaagatctg  cccaggctg  tgagcagga  240
gaaatgagg  ttgagctgc  gagatctgc  aactcaaac  cggctatgg  accccgaga  300
cgcaaagct  gctgcaaga  tttcttctg  aagactttc  catcctgtt  g  351



<210> 2700
<211> 116
<212> PRT
<213> Homo sapiens
<308> NP_001039
<400> 2700

Met Leu Ser Cys Arg Leu Gln Cys Ala Leu Ala Ala Leu Ser Ile Val 
  1               5                  10                  15
Leu Ala Leu Gly Cys Val Thr Gly Ala Pro Ser Asp Pro Arg Leu Arg 
             20                  25                  30
Gln Phe Leu Gln Lys Ser Leu Ala Ala Ala Ala Gly Lys Gln Glu Leu 
         35                  40                  45
Ala Lys Tyr Phe Leu Ala Glu Leu Leu Ser Glu Pro Asn Gln Thr Glu 
     50                  55                  60
Asn Asp Ala Leu Glu Pro Glu Asp Leu Ser Gln Ala Ala Glu Gln Asp 
 65                  70                  75                  80
Glu Met Arg Leu Glu Leu Gln Arg Ser Ala Asn Ser Asn Pro Ala Met 
                 85                  90                  95
Ala Pro Arg Glu Arg Lys Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr 
             100                105                110
Phe Thr Ser Cys 
         115



<210> 2701
<211> 356
<212> DNA
<213> Rattus norvegicus
<308> K02423
<400> 2701

gccaccccc  tggacaagt  aaccgtcca  tccagccgc  tgtgtcaag  ttctattag  60
cactaagag  aatatatat  catgccctt  taccattca  cactctggg  ccaccctcc  120
gacgctggg  tgcgggtca  gcgagccac  actgctctt  caagtgtca  tttgacagg  180
tcttctgga  gagatcctt  ttttgttaa  ccatcgttt  aatcaaaat  gcaccaaag  240
aagacgtga  gaagcccgc  gctgctgct  ctgctcctg  cccagcccc  gccccggcc  300
ctgccccag  caaacctaa  gaagaaaaa  tcgatctgt  tgctattaa  gtaact  356



<210> 2702
<211> 188
<212> PRT
<213> Rattus norvegicus
<308> AAA98533
<400> 2702

Ala Pro Lys Lys Asp Val Lys Lys Pro Ala Ala Ala Ala Pro Ala Pro 
  1               5                  10                  15
Ala Pro Ala Pro Ala Pro Ala Pro Ala Lys Pro Lys Glu Glu Lys Ile 
             20                  25                  30
Asp Leu Ser Ala Ile Lys Ile Glu Phe Ser Lys Glu Gln Gln Glu Glu 
         35                  40                  45
Phe Lys Glu Ala Phe Leu Leu Phe Asp Arg Thr Gly Glu Cys Lys Ile 
     50                  55                  60
Thr Leu Ser Gln Val Gly Asp Val Leu Arg Ala Leu Gly Thr Asn Pro 
 65                  70                  75                  80
Thr Asn Ala Glu Val Lys Lys Val Leu Gly Asn Pro Ser Asn Glu Glu 
                 85                  90                  95
Met Asn Ala Lys Lys Ile Glu Phe Glu Gln Phe Leu Pro Met Met Gln 
             100                105                110
Ala Ile Ser Asn Asn Lys Asp Gln Gly Gly Tyr Glu Asp Phe Val Glu 
         115                120                125
Gly Leu Arg Val Phe Asp Lys Glu Gly Asn Gly Thr Val Met Gly Ala 
     130                135                140
Glu Leu Arg His Val Leu Ala Thr Leu Gly Glu Lys Met Lys Glu Glu 
 145                150                155                160
Glu Val Glu Ala Leu Leu Ala Gly Gln Glu Asp Ser Asn Gly Cys Ile 
                 165                170                175
Asn Tyr Glu Ala Phe Val Lys His Ile Met Ser Val 
             180                185



<210> 2703
<211> 1045
<212> DNA
<213> Homo sapiens
<308> XM_030823
<400> 2703

acactctgg  tccatcttc  agacactgg  ctgtggatc  acccaacca  cactcctct  60
ccaagaatc  ttttgacag  ttcttttgg  ggaactcct  ctcttttta  cccaccctt  120
taaaaaaaa  aatggcacc  aagaaagac  tgaagaaac  tgtggctgc  gctgcggct  180
ccccagccc  ggcaccggc  cctgcacct  cccctgccc  agccaaacc  aaagaagaa  240
aaattgacc  ctctgccat  aagatcgag  tctctaagg  acagcagga  gaattcaag  300
aggcatttc  cctgtttga  agaacaggt  attccaaga  caccttaag  caggtcggt  360
atgtccttc  agctctggg  acaaatccc  ccaatgcag  ggtcaggaa  gttctggga  420
accccagca  tgaagagct  aatgccaag  aaattgagt  tgaacaatt  ctgcctatg  480
tgcaagcca  ttccaacaa  aaggaccag  ccacctatg  agactttgt  gagggtctg  540
gtgtctttg  caaggaagg  aatggcaca  tcatgggtg  tgaactccg  catgttcta  600
ccaccctgg  tgaaaagat  aaagaggaa  aagtggaag  cctgatggc  ggtcaagaa  660
actccaatg  ctgcatcaa  tacgaagct  ttgtcaagc  catcatgtc  atctgaatg  720
agctctcaa  aacaagcat  gtttaggaa  actggctgg  aacttattt  aatcacacc  780
atgacaaac  ctccagatc  gtttaccat  attcaggaa  acaaagcaa  ctggacggt  840
caagactga  caactccct  aatttttat  catcttcag  ttttctctg  attgaattc  900
taccacaca  acaaagtgt  tgctgctct  gatgagaag  ataaaatat  gacaatctc  960
aatccaagc  ccattcttt  ttatctacc  tgaatcaac  aacattctt  aaacaataa  1020
tcaataaac  attttggtc  gtctg  1045



<210> 2704
<211> 194
<212> PRT
<213> Homo sapiens
<308> XP_030823
<400> 2704

Met Ala Pro Lys Lys Asp Val Lys Lys Pro Val Ala Ala Ala Ala Ala 
  1               5                  10                  15
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Lys 
             20                  25                  30
Pro Lys Glu Glu Lys Ile Asp Leu Ser Ala Ile Lys Ile Glu Phe Ser 
         35                  40                  45
Lys Glu Gln Gln Asp Glu Phe Lys Glu Ala Phe Leu Leu Phe Asp Arg 
     50                  55                  60
Thr Gly Asp Ser Lys Ile Thr Leu Ser Gln Val Gly Asp Val Leu Arg 
 65                  70                  75                  80
Ala Leu Gly Thr Asn Pro Thr Asn Ala Glu Val Arg Lys Val Leu Gly 
                 85                  90                  95
Asn Pro Ser Asn Glu Glu Leu Asn Ala Lys Lys Ile Glu Phe Glu Gln 
             100                105                110
Phe Leu Pro Met Met Gln Ala Ile Ser Asn Asn Lys Asp Gln Ala Thr 
         115                120                125
Tyr Glu Asp Phe Val Glu Gly Leu Arg Val Phe Asp Lys Glu Gly Asn 
     130                135                140
Gly Thr Val Met Gly Ala Glu Leu Arg His Val Leu Ala Thr Leu Gly 
 145                150                155                160
Glu Lys Met Lys Glu Glu Glu Val Glu Ala Leu Met Ala Gly Gln Glu 
                 165                170                175
Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe Val Lys His Ile Met 
             180                185                190
Ser Ile 
         195



<210> 2705
<211> 681
<212> DNA
<213> Rattus norvegicus
<308> K02815
<400> 2705

tcagcccaa  accctcatc  gctttgtag  caacatctt  cctcctgtg  tcaatatca  60
atggttgag  aacagcaag  cagtcacag  aggcgttta  gagaccagc  tcctttcca  120
ccctgacca  tccttccac  agatggctt  cctcacctt  atcccttcc  acgacgaca  180
ttatgactg  aaggtggag  actggggcc  ggacgagcc  gttctaaaa  actgggaac  240
tgaggttcc  gcccccatg  cagagctga  agagactgt  gtctgtgcc  tggggttgt  300
tgtgggcct  gtgggcatc  tggtgggca  catcttcat  attcaaggc  tgcgatcag  360
tggcccctc  agacaccca  ggccccttt  agtcacacc  tgggaaaga  ggtgcgtgg  420
cctctacag  caagatgta  tgtgagggg  gacctggca  agtgtgttt  ctgccccaa  480
tcatcgtgt  ctttctctt  tcctggtgt  tcccatctt  ctcttccct  ggcccccag  540
ctgtccacc  catggctct  acgcccttg  aattctccc  tgacctgag  ttcattttt  600
gcatcttcc  agtcgaatc  actatagat  ccgagaccc  gattgatgc  ccaccaaac  660
aataaacct  tcataagtt  g  681



<210> 2706
<211> 728
<212> DNA
<213> Homo sapiens
<308> M17847
<400> 2706

tttccaagt  tcccgtgac  ctgggtcag  ccaacaccc  catctgtct  gtggacaac  60
tctttcctc  tgtggtcaa  atcacatgg  ttagcaatg  gcacgcagt  acagaaggt  120
tttctgaga  cagcttcct  tccaagagt  atcattcct  cttcaagat  agttacctc  180
ccttcctcc  ttctgctga  gagatttat  actgcaagg  ggagcactg  ggcctggac  240
agcctcttc  gaaacactg  gagcctgag  ttccagccc  tatgtcaga  ctcacagag  300
ctgtggtct  tgccctggg  ttgtctgtg  gcctcgtgg  cattgtggt  ggcactgtc  360
tcatcatcc  aggcctgcg  tcagttggt  cttccagac  ccaagggcc  ttgtgaatc  420
catcctgga  gggaaggtg  atcgccatc  acaggaaca  aagaatgga  ttgctaaat  480
acctagcac  attctctgg  ccgatttat  atatccctt  tctcctcca  atgtttctc  540
tctcacctt  tctctggga  ttaagctgc  atatcccct  agagctcac  aatgccttt  600
cattatttc  ctgacctcc  gattttttt  ttcttttct  aaatgttac  tacaaagac  660
tgcctgggg  aagccaccc  gctccctaa  tcctcagta  cctccatct  aaatctcca  720
ggaagcat  728



<210> 2707
<211> 255
<212> PRT
<213> Homo sapiens
<308> P01907
<400> 2707

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
  1               5                  10                  15
Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
             20                  25                  30
Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr 
         35                  40                  45
Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Glu Arg 
     50                  55                  60
Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
 65                  70                  75                  80
Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                 85                  90                  95
Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
             100                105                110
Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
         115                120                125
Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
     130                135                140
Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Asp Val Ser Glu 
 145                150                155                160
Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                 165                170                175
Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
             180                185                190
His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
         195                200                205
Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
     210                215                220
Leu Ser Val Gly Leu Met Gly Ile Val Val Gly Thr Val Phe Ile Ile 
 225                230                235                240
Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                 245                250                255



<210> 2708
<211> 593
<212> DNA
<213> Rattus norvegicus
<308> K03045
<400> 2708

ggctgcagc  tcctctcgc  aaggaaagg  tgcctgccc  ttctaggga  tcagtggtt  60
gcaagttgg  cagggcccc  gggctactg  gtctctctg  cttacagac  atgaccact  120
gatcatcga  acggactac  acaccttcg  tctgcagta  tcctgccgc  tgcagaatc  180
ggatggcac  tgtgcagac  gctactcct  tgtgttttc  cgtgacccc  atggcctga  240
cccggagac  cggaggctg  tgaggcagc  acaggagga  ctgtgccta  agaggcagt  300
cagatggat  gagcacaat  gtggagcaa  tcttcctga  ggacttagc  gggctggga  360
gataagagg  gcagcatct  tgcaagtgg  ttacccgag  cctcctttg  accaagtct  420
attaaattt  tccaggact  ccatcagcc  cacagacaa  gaccaaagg  ttctcttcc  480
ctaaacgct  ggcactttt  tataaccaa  gttgtgaaa  cactctctt  ttatgtttt  540
gctccccac  tttgctgct  gtgcacaag  cgagaccat  gcaagataa  gtt  593



<210> 2709
<211> 201
<212> PRT
<213> Rattus norvegicus
<308> AAB06955
<400> 2709

Met Glu Trp Val Trp Ala Leu Val Leu Leu Ala Ala Leu Gly Gly Gly 
  1               5                  10                  15
Ser Ala Glu Arg Asp Cys Arg Val Ser Ser Phe Arg Val Lys Glu Asn 
             20                  25                  30
Phe Asp Lys Ala Arg Phe Ser Gly Leu Trp Tyr Ala Ile Ala Lys Lys 
         35                  40                  45
Asp Pro Glu Gly Leu Phe Leu Gln Asp Asn Ile Ile Ala Glu Phe Ser 
     50                  55                  60
Val Asp Glu Lys Gly His Met Ser Ala Thr Ala Lys Gly Arg Val Arg 
 65                  70                  75                  80
Leu Leu Ser Asn Trp Glu Val Cys Ala Asp Met Val Gly Thr Phe Thr 
                 85                  90                  95
Asp Thr Glu Asp Pro Ala Lys Phe Lys Met Lys Tyr Trp Gly Val Ala 
             100                105                110
Ser Phe Leu Gln Arg Gly Asn Asp Asp His Trp Ile Ile Asp Thr Asp 
         115                120                125
Tyr Asp Thr Phe Ala Leu Gln Tyr Ser Cys Arg Leu Gln Asn Leu Asp 
     130                135                140
Gly Thr Cys Ala Asp Ser Tyr Ser Phe Val Phe Ser Arg Asp Pro Asn 
 145                150                155                160
Gly Leu Ser Pro Glu Thr Arg Arg Leu Val Arg Gln Arg Gln Glu Glu 
                 165                170                175
Leu Cys Leu Glu Arg Gln Tyr Arg Trp Ile Glu His Asn Gly Tyr Cys 
             180                185                190
Gln Ser Arg Pro Ser Arg Asn Ser Leu 
         195                200



<210> 2710
<211> 919
<212> DNA
<213> Homo sapiens
<308> NM_006744
<400> 2710

cgctcgcct  cctcgctcc  cgcgcgccc  gacgcggcg  ccaggcttg  gcgtggttc  60
cctcccggt  ggcggattc  tgggcaaga  gaagtgggt  tgggcgctc  tgctgttgg  120
ggcgtgggc  gcggccgag  gcgactgcc  agtgagcag  ttccgagtc  aggagaact  180
cgacaaggc  cgcttctct  ggacctggt  cgccatggc  aagaaggac  ccgagggcc  240
ctttctgca  gacaacatc  tcgcggagt  ctcggtgga  gagaccggc  agatgagcg  300
cacagccaa  ggccgagtc  gtcttttga  taactggga  gtgtgcgca  acatggtgg  360
caccttcac  gacaccgag  accctgcca  gttcaagat  aagtactgg  gcgtagcct  420
ctttctgca  aaaggaaat  atgaccact  gatcgtcga  acagactac  acacgtatg  480
cgtacagta  tcctgccgc  tcctgaacc  cgatggcac  tgtgctgac  gctactcct  540
cgtgttttc  cgggacccc  acggcctgc  cccagaagc  cagaagatt  taaggcagc  600
gcaggagga  ctgtgcctg  ccaggcagt  caggctgat  gtccacaac  gttactgcg  660
tggcagatc  gaaagaaac  ttttgtagc  atatcaaga  tctagtttc  tctgagaac  720
tctgattag  tctcagtct  cagctctat  tatcttagg  gtttaattt  cccttctct  780
cccatcttc  ctcagttcc  ataaaacct  cattacaca  aaagataca  gtgggggtc  840
gtgaatctg  ttgcctttc  tgaaagttt  tggggctta  gattccaga  tctgattca  900
taaactata  tcacccgtg  919



<210> 2711
<211> 201
<212> PRT
<213> Homo sapiens
<308> P02753
<400> 2711

Met Lys Trp Val Trp Ala Leu Phe Leu Leu Ala Ala Leu Gly Ser Gly 
  1               5                  10                  15
Arg Ala Glu Arg Asp Cys Arg Val Ser Ser Phe Arg Val Lys Glu Asn 
             20                  25                  30
Phe Asp Lys Ala Arg Phe Ser Gly Thr Trp Tyr Ala Met Ala Lys Lys 
         35                  40                  45
Asp Pro Glu Gly Leu Phe Leu Gln Asp Asn Ile Val Ala Glu Phe Ser 
     50                  55                  60
Val Asp Glu Thr Gly Gln Met Ser Ala Thr Ala Lys Gly Arg Val Arg 
 65                  70                  75                  80
Leu Leu Asn Asn Trp Asp Val Cys Ala Asp Met Val Gly Thr Phe Thr 
                 85                  90                  95
Asp Thr Glu Asp Pro Ala Lys Phe Lys Met Lys Tyr Trp Gly Val Ala 
             100                105                110
Ser Phe Leu Gln Lys Gly Asn Asp Asp His Trp Ile Val Asp Thr Asp 
         115                120                125
Tyr Asp Thr Tyr Ala Val Gln Tyr Ser Cys Arg Leu Leu Asn Leu Asp 
     130                135                140
Gly Thr Cys Ala Asp Ser Tyr Ser Phe Val Phe Ser Arg Asp Pro Asn 
 145                150                155                160
Gly Leu Pro Pro Glu Ala Gln Lys Ile Val Arg Gln Arg Gln Glu Glu 
                 165                170                175
Leu Cys Leu Ala Arg Gln Tyr Arg Leu Ile Val His Asn Gly Tyr Cys 
             180                185                190
Asp Gly Arg Ser Glu Arg Asn Leu Leu 
         195                200



<210> 2712
<211> 593
<212> DNA
<213> Rattus norvegicus
<308> K03045
<400> 2712

ggctgcagc  tcctctcgc  aaggaaagg  tgcctgccc  ttctaggga  tcagtggtt  60
gcaagttgg  cagggcccc  gggctactg  gtctctctg  cttacagac  atgaccact  120
gatcatcga  acggactac  acaccttcg  tctgcagta  tcctgccgc  tgcagaatc  180
ggatggcac  tgtgcagac  gctactcct  tgtgttttc  cgtgacccc  atggcctga  240
cccggagac  cggaggctg  tgaggcagc  acaggagga  ctgtgccta  agaggcagt  300
cagatggat  gagcacaat  gtggagcaa  tcttcctga  ggacttagc  gggctggga  360
gataagagg  gcagcatct  tgcaagtgg  ttacccgag  cctcctttg  accaagtct  420
attaaattt  tccaggact  ccatcagcc  cacagacaa  gaccaaagg  ttctcttcc  480
ctaaacgct  ggcactttt  tataaccaa  gttgtgaaa  cactctctt  ttatgtttt  540
gctccccac  tttgctgct  gtgcacaag  cgagaccat  gcaagataa  gtt  593



<210> 2713
<211> 201
<212> PRT
<213> Rattus norvegicus
<308> AAB06955
<400> 2713

Met Glu Trp Val Trp Ala Leu Val Leu Leu Ala Ala Leu Gly Gly Gly 
  1               5                  10                  15
Ser Ala Glu Arg Asp Cys Arg Val Ser Ser Phe Arg Val Lys Glu Asn 
             20                  25                  30
Phe Asp Lys Ala Arg Phe Ser Gly Leu Trp Tyr Ala Ile Ala Lys Lys 
         35                  40                  45
Asp Pro Glu Gly Leu Phe Leu Gln Asp Asn Ile Ile Ala Glu Phe Ser 
     50                  55                  60
Val Asp Glu Lys Gly His Met Ser Ala Thr Ala Lys Gly Arg Val Arg 
 65                  70                  75                  80
Leu Leu Ser Asn Trp Glu Val Cys Ala Asp Met Val Gly Thr Phe Thr 
                 85                  90                  95
Asp Thr Glu Asp Pro Ala Lys Phe Lys Met Lys Tyr Trp Gly Val Ala 
             100                105                110
Ser Phe Leu Gln Arg Gly Asn Asp Asp His Trp Ile Ile Asp Thr Asp 
         115                120                125
Tyr Asp Thr Phe Ala Leu Gln Tyr Ser Cys Arg Leu Gln Asn Leu Asp 
     130                135                140
Gly Thr Cys Ala Asp Ser Tyr Ser Phe Val Phe Ser Arg Asp Pro Asn 
 145                150                155                160
Gly Leu Ser Pro Glu Thr Arg Arg Leu Val Arg Gln Arg Gln Glu Glu 
                 165                170                175
Leu Cys Leu Glu Arg Gln Tyr Arg Trp Ile Glu His Asn Gly Tyr Cys 
             180                185                190
Gln Ser Arg Pro Ser Arg Asn Ser Leu 
         195                200



<210> 2714
<211> 919
<212> DNA
<213> Homo sapiens
<308> NM_006744
<400> 2714

cgctcgcct  cctcgctcc  cgcgcgccc  gacgcggcg  ccaggcttg  gcgtggttc  60
cctcccggt  ggcggattc  tgggcaaga  gaagtgggt  tgggcgctc  tgctgttgg  120
ggcgtgggc  gcggccgag  gcgactgcc  agtgagcag  ttccgagtc  aggagaact  180
cgacaaggc  cgcttctct  ggacctggt  cgccatggc  aagaaggac  ccgagggcc  240
ctttctgca  gacaacatc  tcgcggagt  ctcggtgga  gagaccggc  agatgagcg  300
cacagccaa  ggccgagtc  gtcttttga  taactggga  gtgtgcgca  acatggtgg  360
caccttcac  gacaccgag  accctgcca  gttcaagat  aagtactgg  gcgtagcct  420
ctttctgca  aaaggaaat  atgaccact  gatcgtcga  acagactac  acacgtatg  480
cgtacagta  tcctgccgc  tcctgaacc  cgatggcac  tgtgctgac  gctactcct  540
cgtgttttc  cgggacccc  acggcctgc  cccagaagc  cagaagatt  taaggcagc  600
gcaggagga  ctgtgcctg  ccaggcagt  caggctgat  gtccacaac  gttactgcg  660
tggcagatc  gaaagaaac  ttttgtagc  atatcaaga  tctagtttc  tctgagaac  720
tctgattag  tctcagtct  cagctctat  tatcttagg  gtttaattt  cccttctct  780
cccatcttc  ctcagttcc  ataaaacct  cattacaca  aaagataca  gtgggggtc  840
gtgaatctg  ttgcctttc  tgaaagttt  tggggctta  gattccaga  tctgattca  900
taaactata  tcacccgtg  919



<210> 2715
<211> 201
<212> PRT
<213> Homo sapiens
<308> P02753
<400> 2715

Met Lys Trp Val Trp Ala Leu Phe Leu Leu Ala Ala Leu Gly Ser Gly 
  1               5                  10                  15
Arg Ala Glu Arg Asp Cys Arg Val Ser Ser Phe Arg Val Lys Glu Asn 
             20                  25                  30
Phe Asp Lys Ala Arg Phe Ser Gly Thr Trp Tyr Ala Met Ala Lys Lys 
         35                  40                  45
Asp Pro Glu Gly Leu Phe Leu Gln Asp Asn Ile Val Ala Glu Phe Ser 
     50                  55                  60
Val Asp Glu Thr Gly Gln Met Ser Ala Thr Ala Lys Gly Arg Val Arg 
 65                  70                  75                  80
Leu Leu Asn Asn Trp Asp Val Cys Ala Asp Met Val Gly Thr Phe Thr 
                 85                  90                  95
Asp Thr Glu Asp Pro Ala Lys Phe Lys Met Lys Tyr Trp Gly Val Ala 
             100                105                110
Ser Phe Leu Gln Lys Gly Asn Asp Asp His Trp Ile Val Asp Thr Asp 
         115                120                125
Tyr Asp Thr Tyr Ala Val Gln Tyr Ser Cys Arg Leu Leu Asn Leu Asp 
     130                135                140
Gly Thr Cys Ala Asp Ser Tyr Ser Phe Val Phe Ser Arg Asp Pro Asn 
 145                150                155                160
Gly Leu Pro Pro Glu Ala Gln Lys Ile Val Arg Gln Arg Gln Glu Glu 
                 165                170                175
Leu Cys Leu Ala Arg Gln Tyr Arg Leu Ile Val His Asn Gly Tyr Cys 
             180                185                190
Asp Gly Arg Ser Glu Arg Asn Leu Leu 
         195                200



<210> 2716
<211> 1029
<212> DNA
<213> Rattus norvegicus
<308> K03242
<400> 2716

attcggctg  gcccttgcc  ctaccccag  tatggctcc  ggggctccc  catccagcc  60
cagccctat  ctggctgcc  tgctcttct  ttctttggt  ctgtcccca  ccctggcca  120
tgtggttta  acggacagg  aagtctatg  tgctgtgcg  tcccaggtc  ccctgcact  180
ctccttctg  tccagtgaa  gggtctcag  tgacatctc  tttacctgg  gctaccagc  240
tgaaggagg  cgagatgcc  tttcaatct  ccactatgc  aagggtcaa  cttacatcg  300
tgaggtggg  accttcaag  agcgcatcc  gtgggtagg  gaccctagc  ggaaggatg  360
ctccattgt  atacacaac  tagactaca  tgacaacgg  actttcaca  gtgatgtca  420
aaacccacc  gacatagtg  gcaagacgt  tcaggtcac  ctctatgtc  ttgaaaaag  480
gcccactag  tatggggtg  tgttgggag  cgtgatcgg  ggcatcctc  gggtggtgc  540
gttgctgct  ttgctcttc  acctgatcc  gtactgctg  ctgcgcagg  aggctgccc  600
gcagaggag  ctcagtgcc  tggagaagg  gaaatttca  aagtcttct  aggactcct  660
gaagcgcgg  cggcagacg  cagtgctgt  tgccatgct  gaccacagc  gaagcacca  720
agctgccag  gagaagaaa  ctaaagggc  gggggagtc  cgcaaggat  agaaatagc  780
gttagcggg  cgggcgggg  gtcgggggt  tgcgatgga  tcttccaaa  gctctcagg  840
ggtggtcat  gagatggag  ttcgcaaag  tgagcagag  tcggagccc  ggcctgcag  900
caaatcccc  agtagaacc  gcctcaaga  cgccctcaa  aacatgatg  gcctggact  960
gaacaagtg  ccgtcacct  caggctctg  cagagcagg  gacctaggc  cctcttttt  1020
ccagtctag  1029



<210> 2717
<211> 248
<212> PRT
<213> Rattus norvegicus
<308> P06907
<400> 2717

Met Ala Pro Gly Ala Pro Ser Ser Ser Pro Ser Pro Ile Leu Ala Ala 
  1               5                  10                  15
Leu Leu Phe Ser Ser Leu Val Leu Ser Pro Thr Leu Ala Ile Val Val 
             20                  25                  30
Tyr Thr Asp Arg Glu Val Tyr Gly Ala Val Gly Ser Gln Val Thr Leu 
         35                  40                  45
His Cys Ser Phe Trp Ser Ser Glu Trp Val Ser Asp Asp Ile Ser Phe 
     50                  55                  60
Thr Trp Arg Tyr Gln Pro Glu Gly Gly Arg Asp Ala Ile Ser Ile Phe 
 65                  70                  75                  80
His Tyr Ala Lys Gly Gln Pro Tyr Ile Asp Glu Val Gly Thr Phe Lys 
                 85                  90                  95
Glu Arg Ile Gln Trp Val Gly Asp Pro Ser Trp Lys Asp Gly Ser Ile 
             100                105                110
Val Ile His Asn Leu Asp Tyr Ser Asp Asn Gly Thr Phe Thr Cys Asp 
         115                120                125
Val Lys Asn Pro Pro Asp Ile Val Gly Lys Thr Ser Gln Val Thr Leu 
     130                135                140
Tyr Val Phe Glu Lys Val Pro Thr Arg Tyr Gly Val Val Leu Gly Ala 
 145                150                155                160
Val Ile Gly Gly Ile Leu Gly Val Val Leu Leu Leu Leu Leu Leu Phe 
                 165                170                175
Tyr Leu Ile Arg Tyr Cys Trp Leu Arg Arg Gln Ala Ala Leu Gln Arg 
             180                185                190
Arg Leu Ser Ala Met Glu Lys Gly Lys Phe His Lys Ser Ser Lys Asp 
         195                200                205
Ser Ser Lys Arg Gly Arg Gln Thr Pro Val Leu Tyr Ala Met Leu Asp 
     210                215                220
His Ser Arg Ser Thr Lys Ala Ala Ser Glu Lys Lys Ser Lys Gly Leu 
 225                230                235                240
Gly Glu Ser Arg Lys Asp Lys Lys 
                 245



<210> 2718
<211> 813
<212> DNA
<213> Homo sapiens
<308> AI557264
<400> 2718

naccgttgg  ggggtgaat  acttcttcg  cgtaaaggt  ggccgaacc  tatgtacca  60
gtcccagcc  aacttggac  cctgtgcct  ccatgaaca  ccagaactg  agaagaaac  120
gttgtgctc  ttcgagatc  acgaattcc  tgggagaac  gaaggtccc  ggtgaaatc  180
aggtgtcaa  aatcctagg  atctgtgcc  ggccattcg  accagccac  acccactcc  240
accccctgt  gtgctccca  ccctggact  gtggccccc  ccctgcggg  ggcctcccc  300
tgtgcctgc  ccaagagac  gacagagaa  gctgcagga  tcctttgtt  ctcagcagg  360
cgctctgcc  tccctcctt  cttcttgct  ctaatagcc  tggtacatg  tacacaccc  420
cccacctcc  gcaattaaa  agtagcatc  ccaaaaaaa  aaaaaaaaa  ctcgagggg  480
ggccggtac  caattcgcc  tatagtgag  cgtattaca  ttcactggc  gtcgttttc  540
acgtcgtga  tgggaaacc  tggcgtacc  aacttaatc  cttgaggan  tcccccttt  600
gccagtggg  aatagcgag  ggcccngac  gattggcct  caanagttn  nnntnaatg  660
nnntggaaa  tgtaanggt  aaatttgta  atngggtaa  nttttgtna  atagcnatt  720
tnnaccant  gnngaatng  naaaatccc  ntanantaa  ngnaatggc  cgnnnnggg  780
nagngttnt  agttgggaa  angtaccat  ttt  813



<210> 2719
<211> 141
<212> PRT
<213> Homo sapiens
<308> P01037
<400> 2719

Met Ala Gln His Leu Ser Thr Leu Leu Leu Leu Leu Ala Thr Leu Ala 
  1               5                  10                  15
Val Ala Leu Ala Trp Ser Pro Lys Glu Glu Asp Arg Ile Ile Pro Gly 
             20                  25                  30
Gly Ile Tyr Asn Ala Asp Leu Asn Asp Glu Trp Val Gln Arg Ala Leu 
         35                  40                  45
His Phe Ala Ile Ser Glu Tyr Asn Lys Ala Thr Lys Asp Asp Tyr Tyr 
     50                  55                  60
Arg Arg Pro Leu Arg Val Leu Arg Ala Arg Gln Gln Thr Val Gly Gly 
 65                  70                  75                  80
Val Asn Tyr Phe Phe Asp Val Glu Val Gly Arg Thr Ile Cys Thr Lys 
                 85                  90                  95
Ser Gln Pro Asn Leu Asp Thr Cys Ala Phe His Glu Gln Pro Glu Leu 
             100                105                110
Gln Lys Lys Gln Leu Cys Ser Phe Glu Ile Tyr Glu Val Pro Trp Glu 
         115                120                125
Asn Arg Arg Ser Leu Val Lys Ser Arg Cys Gln Glu Ser 
     130                135                140



<210> 2720
<211> 1029
<212> DNA
<213> Rattus norvegicus
<308> K03486
<400> 2720

gtgaagatc  tgaagaaag  tgtggtgat  caagatgac  atgtggagt  cacaatggt  60
gagaagagg  tgctggccc  gcctgggaa  cccccattc  tgactcagc  ccattcctg  120
ttccagacc  tggaccgcc  ctactttgt  atggagtat  tgaacgggg  cgacctcat  180
taccacatc  aacaagttg  ccgtttcaa  gagccccat  ctgtatttt  cgctgcaga  240
attgccatc  gtcttttct  cttgcagag  aagggcatc  tttaccgtg  cctgaaact  300
gacaacgtg  tgctggatt  cgaggggca  atcaaaatc  ctgactttg  catgtgtaa  360
gagaatatc  gggatgggg  gacaaccaa  acattctgt  gcactccag  ctacattgc  420
ccagagatc  ttgcttatc  gccctacgg  aagtctgtg  actggtggg  gtttggagt  480
ctgctgtat  aaatgttgg  tggccaggc  ccttttgaa  gggaggatg  ggatgaact  540
ttccagtca  tcatggagc  caacgtggc  tatcccaag  ccatgtcta  ggaagctgt  600
gcaatctgc  aagggctaa  gaccaaaca  ccaggcaag  gcctgggtt  tgggcctga  660
ggggaacga  acattaagg  gcatgcatt  ttccggtat  tcgactggg  gaaactcga  720
cgcaaggag  ttcagccac  ttataaacc  aaagctaga  acaagcgag  caccaactt  780
gacaaagag  tcaccaggc  gcctgtgct  actcccact  acaaactct  catcatgaa  840
ttggaccaa  atgaatttg  tggcttctc  tatactaac  cagagtttg  cattaatgt  900
taggtgaat  cagattcca  cgctgagcc  gtgtgtaag  ctgcaggct  aatgtctat  960
atcanttcc  gtcttccag  attcatggt  cctctgttg  catccgtca  gtggagagc  1020
tgtcttaga  1029



<210> 2721
<211> 671
<212> PRT
<213> Rattus norvegicus
<308> P04410
<400> 2721

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
  1               5                  10                  15
Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
             20                  25                  30
Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
         35                  40                  45
Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
     50                  55                  60
Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
 65                  70                  75                  80
Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                 85                  90                  95
Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
             100                105                110
Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
         115                120                125
Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
     130                135                140
Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
 145                150                155                160
Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Glu Val Leu Ile Val Val 
                 165                170                175
Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
             180                185                190
Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
         195                200                205
Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
     210                215                220
Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
 225                230                235                240
Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                 245                250                255
Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Gly Val Asp 
             260                265                270
Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
         275                280                285
Pro Val Pro Pro Glu Gly Ser Glu Gly Asn Glu Glu Leu Arg Gln Lys 
     290                295                300
Phe Glu Arg Ala Lys Ile Gly Gln Gly Thr Lys Ala Pro Glu Glu Lys 
 305                310                315                320
Thr Ala Asn Thr Ile Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                 325                330                335
Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
             340                345                350
Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
         355                360                365
Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
     370                375                380
Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
 385                390                395                400
Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                 405                410                415
Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
             420                425                430
Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
         435                440                445
Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
     450                455                460
Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
 465                470                475                480
Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                 485                490                495
Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
             500                505                510
Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
         515                520                525
Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
     530                535                540
Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
 545                550                555                560
Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                 565                570                575
Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
             580                585                590
Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
         595                600                605
Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Arg Asp Lys 
     610                615                620
Arg Asp Thr Ser Asn Phe Asp Lys Glu Phe Thr Arg Gln Pro Val Glu 
 625                630                635                640
Leu Thr Pro Thr Asp Lys Leu Phe Ile Met Asn Leu Asp Gln Asn Glu 
                 645                650                655
Phe Ala Gly Phe Ser Tyr Thr Asn Pro Glu Phe Val Ile Asn Val 
             660                665                670



<210> 2722
<211> 2209
<212> DNA
<213> Homo sapiens
<308> AK057555
<400> 2722

ggacatggt  gagatggac  ctacccagg  aacagctcc  tcagcatct  agcctgccc  60
actctagcc  cacataccc  cgtgtactc  tgagttcag  gtgcccacc  cactcccac  120
ccctcacat  gacttggca  gagtaagga  ggaactcca  agagacatt  tacctatct  180
aggggagca  ccacaaaga  gcaagtctt  taaaaggtc  tttgcaaag  agagtgaac  240
cagcaatga  agatcctta  cagctagtg  ccattaggg  gctaaacct  aagcctggg  300
ggtgatggc  caaacgcta  tgagtcagt  aatccttac  gaccccctg  cctttataa  360
ctgaggcaa  tttggctgc  gcccgggaa  gtgcagggc  ctagggaat  caaggcctt  420
ttccctggt  gtcttgtaa  aaaacagcc  tggggttgt  cctccagtc  gagagactg  480
gataaggcc  acatagcag  gatgtggtc  ggtaaaaat  aggaaccca  tgaaatctt  540
ggcaagcca  cctgcctgc  tgtgcctcg  ttctctcat  tgtcatata  aggaggtga  600
gactccagc  ccacctgcc  caggtgggt  tggtgatga  gaggaaaga  aagaggctt  660
caaggaccc  gaagaggtc  gagcatcat  cagattcct  tattagccc  cattctgat  720
ttccctggt  agacttgcc  caagcaatt  ctagtaaat  ggggttaat  tcttctcca  780
ctccctact  aacaaaaaa  gaaatgcca  acttactag  agaatcgag  tgctttgag  840
ttcttttgt  ttgttttgt  ttgttttgt  ttaaggctc  ccttacaca  cctccttta  900
gctttgggt  ttctctctt  tagtttgtt  acacatgct  aaaatgtct  tggagagaa  960
ttctgcctg  taaacaccc  attctagac  gtgggtgga  tttcgagct  acggtggtc  1020
attcctttc  ttaagcagt  atctgattt  tccacatgg  cattctgcc  tcttggggg  1080
agagtagat  ggcagcagt  caccttttc  gagaaagag  tcttctagc  acctgggct  1140
ctactgaat  gttttctcc  ggacgctct  cctaatgat  atttctata  cattaagca  1200
ggtaataag  agcttccaa  tcaattcat  ctaaagcca  agaaaatac  gcaacacac  1260
cacacacac  cacacacac  cacacacac  cacacacac  caccacttt  tggcaattc  1320
taactgaca  tcaatgact  acttctttt  ttagaaaat  tccaccaca  ttctatccc  1380
aagccaaca  acaatgtga  atgaaagcc  gtgcgtgga  tgcagctgc  aaaaatttt  1440
agcacaggg  tctttctga  tctgctcat  agatggtat  agccaccca  tgactggcg  1500
atcttggtc  tgtgtcttt  ttcttatgc  gtgttaatg  gtttacttt  catttggca  1560
agagacaag  gagacacct  caacttcga  aaagagttc  ccagacagc  tgtggaact  1620
acccccact  ataaactct  catcatgaa  ttggaccaa  atgaatttg  tggcttctc  1680
tatactaac  cagagtttg  cattaatgt  taggtgaat  caaactcca  cgttgagcc  1740
ggggtgtaa  acttcaagc  aagcgtatg  atcaattct  gtcttccag  attcacggt  1800
cacatgctg  cattcaaca  gtggaaagc  tgtcttaga  ggcttttct  tgtatgtgt  1860
gcttgctag  ttgttttct  catttgaaa  tgtttagtt  agaataagc  cattatcca  1920
ttatagagg  acaattttc  aaacttcca  aaactcatc  aatgaacag  caatgtcaa  1980
actactgtg  ctgatacca  aatgcttca  tatttgtaa  ttttcaagt  agaagctga  2040
gttcctggt  aaagttttt  cagttattc  ataatatct  ctttgaatg  taagcatga  2100
cgatatttt  aaaaattgt  agtaagctt  gcagttact  tgaactatt  tctcttgga  2160
gaagttttt  gtttaagaa  tgatatgat  aaactgaat  aatatatgc  2209



<210> 2723
<211> 673
<212> PRT
<213> Homo sapiens
<308> NP_002729
<400> 2723

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
  1               5                  10                  15
Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
             20                  25                  30
Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
         35                  40                  45
Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
     50                  55                  60
Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
 65                  70                  75                  80
Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                 85                  90                  95
Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
             100                105                110
Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
         115                120                125
Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
     130                135                140
Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
 145                150                155                160
Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                 165                170                175
Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
             180                185                190
Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
         195                200                205
Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
     210                215                220
Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
 225                230                235                240
Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                 245                250                255
Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
             260                265                270
Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
         275                280                285
Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
     290                295                300
Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
 305                310                315                320
Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                 325                330                335
Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
             340                345                350
Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
         355                360                365
Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
     370                375                380
Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
 385                390                395                400
Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                 405                410                415
Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
             420                425                430
Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
         435                440                445
Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
     450                455                460
Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
 465                470                475                480
Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                 485                490                495
Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
             500                505                510
Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
         515                520                525
Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
     530                535                540
Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
 545                550                555                560
Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                 565                570                575
Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
             580                585                590
Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
         595                600                605
Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys Gly Arg 
     610                615                620
Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro Val Leu 
 625                630                635                640
Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser Glu Phe 
                 645                650                655
Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu Val Lys 
             660                665                670
Ser 
         675



<210> 2724
<211> 168
<212> DNA
<213> Rattus norvegicus
<308> L00382
<400> 2724

tgcttcccc  cacagagac  ttggctagt  ccaaggaag  gaacgtgga  attcaccag  60
ccttggacc  gacccttct  gaactcaac  acctgtaag  gtggccctg  tacctgccg  120
ccagactac  tagatgcct  ctcaggcca  taaacggat  tctctggc  168



<210> 2725
<211> 284
<212> PRT
<213> Rattus norvegicus
<308> AAA42289
<400> 2725

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
  1               5                  10                  15
Asn Ala Ile Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Gln Ala 
             20                  25                  30
Glu Asp Arg Cys Lys Gln Leu Glu Glu Glu Gln Gln Ala Leu Gln Lys 
         35                  40                  45
Lys Leu Lys Gly Thr Glu Asp Glu Val Glu Lys Tyr Ser Glu Ser Val 
     50                  55                  60
Lys Asp Ala Gln Glu Lys Leu Glu Gln Ala Glu Lys Lys Ala Thr Asp 
 65                  70                  75                  80
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                 85                  90                  95
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
             100                105                110
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
         115                120                125
Val Ile Glu Asn Arg Ala Met Lys Asp Glu Glu Lys Met Glu Leu Gln 
     130                135                140
Glu Met Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ser Asp Arg 
 145                150                155                160
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Leu Glu Gly Glu Leu 
                 165                170                175
Glu Arg Ser Glu Glu Arg Ala Glu Val Ala Glu Ser Lys Cys Gly Asp 
             180                185                190
Leu Glu Glu Glu Leu Lys Ile Val Thr Asn Asn Leu Lys Ser Leu Glu 
         195                200                205
Ala Gln Ala Asp Lys Tyr Ser Thr Lys Glu Asp Lys Tyr Glu Glu Glu 
     210                215                220
Ile Lys Leu Leu Glu Glu Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
 225                230                235                240
Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu 
                 245                250                255
Glu Asp Glu Val Tyr Ala Gln Lys Met Lys Tyr Lys Ala Ile Ser Glu 
             260                265                270
Glu Leu Asp Asn Ala Leu Asn Asp Ile Thr Ser Leu 
         275                280



<210> 2726
<211> 1044
<212> DNA
<213> Homo sapiens
<308> NM_003289
<400> 2726

tgctgctct  ctcccgctc  gtcctcctc  cctgccacc  gtgcaccca  tccgctcac  60
cagcccagt  cgtccggtc  tcaccgcct  ccggccggc  cacccccca  cgcaggcca  120
ggacgccat  aagaagaag  tgcagatgc  gaagctgga  aaggagaac  ccatcgacc  180
cgccgagca  gccgaagcc  acaagaagc  agctgagga  cgctgcaag  agctggagg  240
ggagcagca  gccctccag  agaagctga  ggggacaga  gatgaggtg  aaaagtatt  300
tgaatccgt  aaggaggcc  aggagaaac  ggagcaggc  gagaagaag  ccactgatg  360
tgaggcaga  gtggcctcc  tgaaccgcc  cattcagct  gttgaggag  agctggacc  420
ggcccagga  cgcctggct  cagccctgc  gaagctgga  gaggccgag  aggcggctg  480
tgagagcga  agaggaatg  aggtcatcg  aaaccgggc  atgaaggat  aggagaaga  540
ggaactgca  gagatgcag  tgaaggagg  caagcacat  gctgaggat  cagaccgca  600
atatgaaga  gtggccagg  agctggtga  cctggaagg  gagctggag  gctcggagg  660
gagggctga  gtggccgag  gccgagcca  acagctgga  gaggaactt  gaaccatgg  720
ccaggccct  aagtccctg  tggcctcag  ggaggagta  tccaccaaa  aagataaat  780
tgaagagga  atcaaactg  tggaggaga  gctgaagga  gctgagacc  gagcagagt  840
tgccgagag  tctgtggca  agttggaga  aaccatcga  gacctagaa  agaccttgg  900
cagtgccaa  gaggagaac  tcgagattc  ccagacctt  gaccagacc  tgctggaac  960
caacaacct  tgagggcca  ccccacccc  agccaggct  tggttgcca  cccaaccca  1020
taaaactga  gttactagc  tctc  1044



<210> 2727
<211> 284
<212> PRT
<213> Homo sapiens
<308> P07951
<400> 2727

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
  1               5                  10                  15
Asn Ala Ile Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Gln Ala 
             20                  25                  30
Glu Asp Arg Cys Lys Gln Leu Glu Glu Glu Gln Gln Ala Leu Gln Lys 
         35                  40                  45
Lys Leu Lys Gly Thr Glu Asp Glu Val Glu Lys Tyr Ser Glu Ser Val 
     50                  55                  60
Lys Glu Ala Gln Glu Lys Leu Glu Gln Ala Glu Lys Lys Ala Thr Asp 
 65                  70                  75                  80
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                 85                  90                  95
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
             100                105                110
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
         115                120                125
Val Ile Glu Asn Arg Ala Met Lys Asp Glu Glu Lys Met Glu Leu Gln 
     130                135                140
Glu Met Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ser Asp Arg 
 145                150                155                160
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Leu Glu Gly Glu Leu 
                 165                170                175
Glu Arg Ser Glu Glu Arg Ala Glu Val Ala Glu Ser Lys Cys Gly Asp 
             180                185                190
Leu Glu Glu Glu Leu Lys Ile Val Thr Asn Asn Leu Lys Ser Leu Glu 
         195                200                205
Ala Gln Ala Asp Lys Tyr Ser Thr Lys Glu Asp Lys Tyr Glu Glu Glu 
     210                215                220
Ile Lys Leu Leu Glu Glu Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
 225                230                235                240
Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu 
                 245                250                255
Glu Asp Glu Val Tyr Ala Gln Lys Met Lys Tyr Lys Ala Ile Ser Glu 
             260                265                270
Glu Leu Asp Asn Ala Leu Asn Asp Ile Thr Ser Leu 
         275                280



<210> 2728
<211> 6036
<212> DNA
<213> Rattus norvegicus
<308> L01115
<400> 2728

tgcccagaa  cacatagct  actacccac  tggagtcct  gcggaagct  tgtcggtta  60
acactacca  gagtaccac  aaaaggaca  cggggaggc  cgggcacgg  gcaggacgg  120
gggacggcc  gccctccgg  ccggagccc  cgagcgcgg  ggggcggcg  ccccgggca  180
gcgccgacc  ttggcagca  gtcatggtt  agcggcctc  tggttccca  agtggatga  240
cggaaaaca  cctggggcg  acgcaatgg  cagaagcgc  cacgccagg  gacccgagc  300
cgtggcttc  gcgcgcccc  ctacatgag  tgcctcaag  atgtggagc  acccagccc  360
actcctgca  ctcgcactc  gtgcccctg  caggatgaa  ccttcatca  gagggctgg  420
ccgggaagg  gtgtgaagc  ggggctgcg  tcagtggcc  tgggttttg  tgacactga  480
gtgaccaca  cgatgggga  agctgaagt  gcacccgac  catcgcctc  aagcggtcc  540
tcctgctgg  accggctag  gcaggtgtt  cagtctaag  agttccgct  cgccaagct  600
gagcgtctg  accagcggt  cttcttcca  atgaaccag  gcagcctca  gctgctcat  660
gcggtgctt  tgctcctca  ggctgtact  ttgaccttc  acgccgcgc  tgccctgcc  720
cagcctgct  atgtggccc  gctgacctg  gcctccgtc  tttttgtgg  actcatggt  780
gtgtgtaac  gacatagct  ccgccagga  tccatgtgg  tagtgagct  tgtggttct  840
ggcatccta  cagccgtgc  agtcggggg  gccctggca  ccaacccac  cagcccctc  900
gcaggcctt  ggtgccccg  gttcttcgt  tacatcacc  acacacttc  tcccattcg  960
atgcgagcg  ccgtgctca  tggcctggg  ctttccacc  tgcatttga  tttggcctg  1020
catctcaac  atggtgacc  cttcctttg  aagcagctc  gtgctaacg  ggtgctctt  1080
ctgtgcacc  atgccatcg  tgtctgcac  cactacccc  ctgaagtgt  tcagcgcca  1140
gcctttcag  agacccgtg  ttacatcca  gcccggctg  acttgcagc  tgagaatcg  1200
cagcaggaa  ggctgctgc  gtcggtgtt  ccccagcat  ttgccatgg  aatgaaaga  1260
gatatcaac  caaaaaagg  agacatgat  ttccacaag  tttacatcc  gaagcatga  1320
aatgtcagc  tcctgtttg  cgacatcga  ggcttcacc  gcctggcct  ccagtgcac  1380
gcccaggaa  tggtcatga  cttgaatga  ctctttgcc  ggttcgaca  gctggctgc  1440
gagaatcac  gtctgagga  caagatctt  ggagactgt  actactgtg  gtcggggct  1500
ccggaggcc  gggcagacc  tgcccactg  tgtgtggag  tgggggtag  catgatcga  1560
gccatctcg  tggtgcgtg  ggtaacggg  gtaaatgtg  acatgcgcg  gggcatcca  1620
agcgggcgt  tacactgcg  tgtccttgg  ctgcggaaa  ggcagtttg  tgtctggtc  1680
aacgatgtg  ccctggcca  ccacatgga  gcggggggc  gggccggcc  catccacat  1740
actcgggcc  cactgcagt  cctgaacgg  gactatgag  tggagccag  ccgtggcgg  1800
gagcgcaac  gctacctca  ggagcagtg  attgagacc  tcctcatac  aggagccag  1860
cagaaacgg  aagaggaga  ggccatgct  gtcaagctg  agcggacgc  ggccaactc  1920
atggaagga  tgatgcccc  ctgggttcc  gaccgtgcc  tctcccgga  caaggactc  1980
aaggcattc  gacagatgg  catcgatga  tctagcaaa  agaaccggg  tgcccaaga  2040
gctctgaac  ctgaggatg  ggtggacga  tttctgggc  gagccatcg  tgcccgaag  2100
atcgaccag  tgcgtaagg  ccatgtgcg  cggttcctg  tcaccttcc  gagggagga  2160
ctcgagaag  agtattcac  gaaagtaga  cctcgtttc  gagcctacg  cgcctgtgc  2220
ctcctggtt  tctgcttca  ctgtttcat  cagttcctc  tattcccac  ctccgccct  2280
atactcggg  tttatgccg  gatcttcct  ttgctgctg  tcaccgtgc  catctgtgc  2340
gtgtgctcc  gtgggtctt  cttccccaa  gccctgcag  gcctgtccc  cagtatcgt  2400
cgctcacgg  tgcacagca  ggctgttgg  gtcttctcg  ttctgcttg  gttcatctc  2460
gccattgcc  acatgttca  ctgcagtca  accccactg  ggacctgtg  ggcccggat  2520
ctgaactta  caccgtccg  tgtcaccgc  tgtcaccta  gacagatca  ttactctct  2580
ggactggaa  ctcccctgt  tgagggcac  gcacccacc  gcagtttcc  tgagtactt  2640
gtcgggagt  tgctgttga  tctcttggc  agctccgtc  tcctccaca  cagcagcat  2700
ggcaagcta  ttatgacct  tgtcttggg  ttcatctac  tgcttctgc  tttgctggg  2760
cccccagcc  ccatctttg  caactatga  ctactgctt  gcgtccatg  cttggcttc  2820
tccaatgag  ccttcgatg  gctggactg  ccagccgta  ggagggtag  gctcaaata  2880
atgacccct  tgattctcc  cgtgttcgc  ctggcactg  atctacacg  acaacaggt  2940
gaatctacc  cccgcctgg  cttcctgtg  aaactgcag  ccacagggg  gaaggagga  3000
atggaggag  tgcaggcct  caaccggcg  ctgctgcat  acatccttc  caaggacgt  3060
gctgcccac  tcctggccc  ggagcgccg  aacgacgag  tgtactacc  atcctgcga  3120
tgcgtggct  tcatgtttg  ctccatcgc  aacttctct  agttctatg  ggaactgga  3180
gcgaacaat  agggcgtgg  gtgcctgcg  ctgctcaat  agatcatcg  ggactttga  3240
gagatcatc  gtgaggaga  gttccggca  ctggagaag  tcaagacca  cggtagcac  3300
tacatggcc  cctccgggc  aaatgccag  acctatgac  aggtcggcc  ctcgcacat  3360
accgccctg  cagactacg  catgcggct  atggagcaa  tgaaacaca  caacgaaca  3420
tctttcaac  acttccaga  gaagatcgg  ttgaacatg  gtccggttg  agcaggtgt  3480
attggggcc  ggaagccac  gtatgacat  tggggaaac  cggtgaatg  ttccagccg  3540
atggacagc  caggagttc  tgaccgaat  caggtgacc  cggatctct  ccaggttct  3600
gctgccaag  gctaccaac  ggagtgtcg  ggggtggtc  aggtgaagg  aaaggggga  3660
atgaccacc  acttcctca  tgggggccc  agcagttag  agaggccag  agtggaaat  3720
caaccaaag  gaccaaggt  ggcactgag  ggacttttc  gctcactgg  tggagctgt  3780
gcagggagc  ctgagcctt  aggtcttgc  gacagcaaa  gggaacacc  cagcaggct  3840
tgcttggac  atatccgtc  gccttcaga  cagcaaagg  agggacgcc  agaggatta  3900
tatccaagt  actttctta  tcagagtaa  gctgtttgc  ttttttttt  ccccccttt  3960
gacgcagct  agagcagag  ctcctgttt  agagtaaaa  ggcaactta  tctgcctac  4020
gtttccctg  ctgggcgac  ggctcaggg  tgggacctt  ctttcccta  ttttcctgg  4080
actattttt  tacaaagac  ggggcaggc  tgaggaatg  ttgccttca  tggcctgtg  4140
cagcagcat  tgtcttggg  actcccagt  ccagccaag  ctccttcct  gcacaacaa  4200
gcagaggaa  gaggtgctg  gggacctag  tctgaccag  tttcagggg  atgtttcca  4260
ttgccaaat  ctagtcccg  gatctgtcc  cagagggga  caaagggac  tctgacagt  4320
aaaatttag  ctcaattcc  gcatgctcc  gggaaaggg  catctggcc  cactggtac  4380
gtgaaagtg  ccagccagg  tgcaagcct  ggtgtgagg  catcagaag  acaggaact  4440
gatgttcac  tgcaggtgc  gaagagtgc  cgcagccag  gaggaggag  aggaggagg  4500
ggagggaga  gaggccaca  tgacctgag  ccccagtgt  cccagggtc  gctctcttg  4560
cccatgtgc  cacttgctg  ctgctggca  ggggcatgg  tcatctcta  cccttgtat  4620
gccaaatag  gaagggtca  ggttccaag  aagataatc  tgaccctaa  cttggcctc  4680
taagtctgg  actagggag  ccctgtgtg  gtgtgtgtc  gtctttctg  ctttctgtc  4740
gtctgtctg  ctgtctgtc  gtctgtctg  ggtctccat  tgtccttat  ctccagctc  4800
tcagctctc  actggggac  gcctctccc  catgggcct  tgtcttctg  tgttaaggc  4860
gggtttcct  tgccaaggg  tggagagta  tttccaggt  gcacaggag  gggatgggg  4920
ttggtagca  aatgagagt  gtctgggga  aggagtccc  tttgtgcca  atccctaag  4980
gccatttga  ggggggggc  catatgcag  atgactgtc  ccctgccta  ggtggggac  5040
caagcacct  cttaatctc  agtgttcct  ggacttgaa  tgttggagg  ttgtgggta  5100
aggctcagg  atttgctga  ttcctcagc  tgtgtctcg  gggtgtggt  atacttcat  5160
actggggtg  tgtgggtcc  ctctcagag  acccagatt  tggtactaa  gggacggag  5220
ctaggaact  ggaacttgg  tgtcccaag  ctttctgcc  gaatctagc  tgactagac  5280
ctagtcctg  ctcccaatc  tcgtgaggc  cgcaagggt  gtactctgt  ctgtcttac  5340
cttgtagcc  ccttgactc  ggtctgaat  agcctggtg  cttgatttc  ctgcaccta  5400
ttaagccag  ggcgtttcg  ctcgatttt  accagcgat  gctttgtct  agatgctga  5460
aggaaaggc  gaggagttt  aggatgtat  ggaggacca  gccagtact  ttgcctttc  5520
ttaagcctt  gccaccagt  cctcgcaga  gcctggttt  gggcttggg  ctactttcc  5580
gggactctc  atgtgccac  cgatggacc  ctaggcgct  aattagcca  ggcagaaga  5640
aggaggatt  tctggtcca  gcagaagat  acctccccg  ctcccccag  catattcta  5700
ccctggtta  gaagggact  ctcgatgcc  atggggtgg  cgtgaggtg  ataaaccaa  5760
gcagggaga  ctcggcttt  ggaactttg  ctgcttctt  ccaggtggg  gggggttgt  5820
tacaccctg  ctccctgca  cacagtgcc  gcctgtcgt  tcctctgag  taccgttgc  5880
cctctcctc  ccagttgat  gaggagtca  ggtacggga  gccatgggc  ctggtttta  5940
aatgtaacc  ctgtgggag  gggggaggg  gacgtacca  gtatttcag  gaaatattt  6000
atatattta  atatcaata  aatcaaact  tttgtg  6036



<210> 2729
<211> 1166
<212> PRT
<213> Rattus norvegicus
<308> Q03343
<400> 2729

Met Ser Trp Phe Ser Gly Leu Leu Val Pro Lys Val Asp Glu Arg Lys 
  1               5                  10                  15
Thr Ala Trp Gly Glu Arg Asn Gly Gln Lys Arg Pro Arg Gln Ala Thr 
             20                  25                  30
Arg Ala Arg Gly Phe Cys Ala Pro Arg Tyr Met Ser Cys Leu Lys Asn 
         35                  40                  45
Val Glu Pro Pro Ser Pro Thr Pro Ala Ala Arg Thr Arg Cys Pro Trp 
     50                  55                  60
Gln Asp Glu Ala Phe Ile Arg Arg Ala Gly Pro Gly Arg Gly Val Lys 
 65                  70                  75                  80
Leu Gly Leu Arg Ser Val Ala Leu Gly Phe Asp Asp Thr Glu Val Thr 
                 85                  90                  95
Thr Pro Met Gly Thr Ala Glu Val Ala Pro Asp Thr Ser Pro Arg Ser 
             100                105                110
Gly Pro Ser Cys Trp His Arg Leu Ala Gln Val Phe Gln Ser Lys Gln 
         115                120                125
Phe Arg Ser Ala Lys Leu Glu Arg Leu Tyr Gln Arg Tyr Phe Phe Gln 
     130                135                140
Met Asn Gln Ser Ser Leu Thr Leu Leu Met Ala Val Leu Val Leu Leu 
 145                150                155                160
Met Ala Val Leu Leu Thr Phe His Ala Ala Pro Ala Leu Pro Gln Pro 
                 165                170                175
Ala Tyr Val Ala Leu Leu Thr Cys Ala Ser Val Leu Phe Val Val Leu 
             180                185                190
Met Val Val Cys Asn Arg His Ser Phe Arg Gln Asp Ser Met Trp Val 
         195                200                205
Val Ser Tyr Val Val Leu Gly Ile Leu Ala Ala Val Gln Val Gly Gly 
     210                215                220
Ala Leu Ala Ala Asn Pro Arg Ser Pro Ser Ala Gly Leu Trp Cys Pro 
 225                230                235                240
Val Phe Phe Val Tyr Ile Thr Tyr Thr Leu Leu Pro Ile Arg Met Arg 
                 245                250                255
Ala Ala Val Leu Ser Gly Leu Gly Leu Ser Thr Leu His Leu Ile Leu 
             260                265                270
Ala Trp His Leu Asn Asn Gly Asp Pro Phe Leu Trp Lys Gln Leu Gly 
         275                280                285
Ala Asn Val Val Leu Phe Leu Cys Thr Asn Ala Ile Gly Val Cys Thr 
     290                295                300
His Tyr Pro Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu Thr Arg 
 305                310                315                320
Gly Tyr Ile Gln Ala Arg Leu His Leu Gln His Glu Asn Arg Gln Gln 
                 325                330                335
Glu Arg Leu Leu Leu Ser Val Leu Pro Gln His Val Ala Met Glu Met 
             340                345                350
Lys Glu Asp Ile Asn Thr Lys Lys Glu Asp Met Met Phe His Lys Ile 
         355                360                365
Tyr Ile Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp Ile Glu 
     370                375                380
Gly Phe Thr Ser Leu Ala Ser Gln Cys Thr Ala Gln Glu Leu Val Met 
 385                390                395                400
Thr Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala Glu Asn 
                 405                410                415
His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser 
             420                425                430
Gly Leu Pro Glu Ala Arg Ala Asp His Ala His Cys Cys Val Glu Met 
         435                440                445
Gly Val Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val Thr Gly 
     450                455                460
Val Asn Val Asn Met Arg Val Gly Ile His Ser Gly Arg Val His Cys 
 465                470                475                480
Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser Asn Asp 
                 485                490                495
Val Thr Leu Ala Asn His Met Glu Ala Gly Gly Arg Ala Gly Arg Ile 
             500                505                510
His Ile Thr Arg Ala Thr Leu Gln Tyr Leu Asn Gly Asp Tyr Glu Val 
         515                520                525
Glu Pro Gly Arg Gly Gly Glu Arg Asn Gly Tyr Leu Lys Glu Gln Cys 
     530                535                540
Ile Glu Thr Phe Leu Ile Leu Gly Ala Ser Gln Lys Arg Lys Glu Glu 
 545                550                555                560
Lys Ala Met Leu Val Lys Leu Gln Arg Thr Arg Ala Asn Ser Met Glu 
                 565                570                575
Gly Leu Met Pro Arg Trp Val Pro Asp Arg Ala Phe Ser Arg Thr Lys 
             580                585                590
Asp Ser Lys Ala Phe Arg Gln Met Gly Ile Asp Asp Ser Ser Lys Glu 
         595                600                605
Asn Arg Gly Ala Gln Asp Ala Leu Asn Pro Glu Asp Glu Val Asp Glu 
     610                615                620
Phe Leu Gly Arg Ala Ile Asp Ala Arg Ser Ile Asp Gln Leu Arg Lys 
 625                630                635                640
Asp His Val Arg Arg Phe Leu Leu Thr Phe Gln Arg Glu Asp Leu Glu 
                 645                650                655
Lys Lys Tyr Ser Arg Lys Val Asp Pro Arg Phe Gly Ala Tyr Val Ala 
             660                665                670
Cys Ala Leu Leu Val Phe Cys Phe Ile Cys Phe Ile Gln Phe Leu Val 
         675                680                685
Phe Pro His Ser Ala Leu Ile Leu Gly Ile Tyr Ala Gly Ile Phe Leu 
     690                695                700
Leu Leu Leu Val Thr Val Leu Ile Cys Ala Val Cys Ser Cys Gly Ser 
 705                710                715                720
Phe Phe Pro Asn Ala Leu Gln Arg Leu Ser Arg Ser Ile Val Arg Ser 
                 725                730                735
Arg Val His Ser Thr Ala Val Gly Val Phe Ser Val Leu Leu Val Phe 
             740                745                750
Ile Ser Ala Ile Ala Asn Met Phe Thr Cys Ser His Thr Pro Leu Arg 
         755                760                765
Thr Cys Ala Ala Arg Met Leu Asn Leu Thr Pro Ser Asp Val Thr Ala 
     770                775                780
Cys His Leu Arg Gln Ile Asn Tyr Ser Leu Gly Leu Glu Ala Pro Leu 
 785                790                795                800
Cys Glu Gly Thr Ala Pro Thr Cys Ser Phe Pro Glu Tyr Phe Val Gly 
                 805                810                815
Ser Val Leu Leu Ser Leu Leu Ala Ser Ser Val Phe Leu His Ile Ser 
             820                825                830
Ser Ile Gly Lys Leu Val Met Thr Phe Val Leu Gly Phe Ile Tyr Leu 
         835                840                845
Leu Leu Leu Leu Leu Gly Pro Pro Ala Thr Ile Phe Asp Asn Tyr Asp 
     850                855                860
Leu Leu Leu Ser Val His Gly Leu Ala Ser Ser Asn Glu Thr Phe Asp 
 865                870                875                880
Gly Leu Asp Cys Pro Ala Val Gly Arg Val Ala Leu Lys Tyr Met Thr 
                 885                890                895
Pro Val Ile Leu Leu Val Phe Ala Leu Ala Leu Tyr Leu His Ala Gln 
             900                905                910
Gln Val Glu Ser Thr Ala Arg Leu Asp Phe Leu Trp Lys Leu Gln Ala 
         915                920                925
Thr Gly Glu Lys Glu Glu Met Glu Glu Leu Gln Ala Tyr Asn Arg Arg 
     930                935                940
Leu Leu His Asn Ile Leu Pro Lys Asp Val Ala Ala His Phe Leu Ala 
 945                950                955                960
Arg Glu Arg Arg Asn Asp Glu Leu Tyr Tyr Gln Ser Cys Glu Cys Val 
                 965                970                975
Ala Val Met Phe Ala Ser Ile Ala Asn Phe Ser Glu Phe Tyr Val Glu 
             980                985                990
Leu Glu Ala Asn Asn Glu Gly Val Glu Cys Leu Arg Leu Leu Asn Glu 
         995                1000                1005
Ile Ile Ala Asp Phe Asp Glu Ile Ile Ser Glu Glu Arg Phe Arg Gln 
     1010                1015                1020
Leu Glu Lys Ile Lys Thr Ile Gly Ser Thr Tyr Met Ala Ala Ser Gly 
 1025                1030                1035                1040
Leu Asn Ala Ser Thr Tyr Asp Gln Val Gly Arg Ser His Ile Thr Ala 
                 1045                1050                1055
Leu Ala Asp Tyr Ala Met Arg Leu Met Glu Gln Met Lys His Ile Asn 
             1060                1065                1070
Glu His Ser Phe Asn Asn Phe Gln Met Lys Ile Gly Leu Asn Met Gly 
         1075                1080                1085
Pro Val Val Ala Gly Val Ile Gly Ala Arg Lys Pro Gln Tyr Asp Ile 
     1090                1095                1100
Trp Gly Asn Thr Val Asn Val Ser Ser Arg Met Asp Ser Thr Gly Val 
 1105                1110                1115                1120
Pro Asp Arg Ile Gln Val Thr Thr Asp Leu Tyr Gln Val Leu Ala Ala 
                 1125                1130                1135
Lys Gly Tyr Gln Leu Glu Cys Arg Gly Val Val Lys Val Lys Gly Lys 
             1140                1145                1150
Gly Glu Met Thr Thr Tyr Phe Leu Asn Gly Gly Pro Ser Ser 
         1155                1160                1165



<210> 2730
<211> 5877
<212> DNA
<213> Homo sapiens
<308> AB007882
<400> 2730

cggacggcg  acggcgggc  ggacggcca  gacgcgcgg  ctcggagga  cgcgggacg  60
ccggccggc  ggccggagc  cgcgggggc  gcggggcgg  ggcccaggg  aggcgcgga  120
ccgggccgg  agcaacatg  catggttta  tggcctcct  gtccctaaa  tggatgaac  180
gaaaacagc  tggggtgaa  gcaatgggc  gaagcgttc  cggcgccgt  gcactcggg  240
aggtggctt  tgcacgccc  gctatatga  ctgcctccg  gatgcagag  cacccagcc  300
cacccctgc  ggcccccct  ggtgcccct  gcaggatga  gccttcatc  ggaggggcg  360
cccaggcaa  ggcaaggag  tggggctgc  ggcagtggc  ctgggcttc  aggataccg  420
ggtgacaac  acagcgggc  ggacggctg  ggtggcgcc  gacgcggtg  ccaggagtg  480
gcgatcctg  tggcgccgt  tggtgcagg  gttccagtc  aagcagttc  gttcggcca  540
gctggagcg  ctgtaccag  ggtacttct  ccagatgaa  cagagcagc  tgacgctgc  600
gatggcggt  ctggtgctg  tcacagcgg  gctgctggc  ttccacgcc  cacccgccc  660
ccctcagcc  gcctatgtg  cactgttgg  ctgtgccgc  gccctgttc  tggggctca  720
ggtggtgtg  aaccggcat  gcttccgcc  ggactccat  tgggtggtg  gctacgtgg  780
gctgggcat  ctggcggca  tgcaggtcg  gggcgctct  gcagcagac  cgcgcagcc  840
ctctgcggg  ctctggtgc  ctgtgttct  tgtctacat  gcctacacg  tcctcccca  900
ccgcatgcg  gctgccgtc  tcagcggcc  gggcctctc  accttgcat  tgatcttgg  960
ctggcaact  aaccgtggt  atgccttcc  ctggaagca  ctcggtgcc  atgtgctgc  1020
gttcctctg  accaacgtc  ttggcatct  cacacacta  ccagcagag  tgtctcagc  1080
ccaggcctt  caggagacc  gcggttaca  ccaggcccg  ctccacctg  agcatgaga  1140
tcggcagca  gagcggctg  tgctgtcgg  attgcccca  cacgttgcc  tggagatga  1200
agaagacat  aacacaaaa  aagaagaca  gatgttcca  aagatctac  tacagaagc  1260
tgacaatgt  agcatcctg  ttgcagaca  tgagggctt  accagcctg  catcccagt  1320
cactgcgca  gagctggtc  tgaccctga  tgagctctt  gcccggttt  acaagctgg  1380
tgcggagaa  cactgcctg  ggatcaaga  cttggggga  tgttactac  gtgtgtcag  1440
gctgccgga  gcccgggcc  accatgccc  ctgctgtgt  gagatgggg  tagacatga  1500
tgaggccat  tcgctggta  gtgaggtga  aggtgtgaa  gtgaacatg  gcgtgggca  1560
ccacagcgg  cgcgtgcac  gcggcgtcc  tggcttgcg  aaatggcag  tcgatgtgt  1620
gtccaatga  gtgaccctg  ccaaccaca  ggaggcagg  ggccgggct  gccgcatcc  1680
catcactcg  gcaacactg  agtacctga  cggggacta  gaggtggag  caggccgtg  1740
tggcgagcg  aacgcgtac  tcaaggagc  gcacattga  actttcctc  tcctgggcg  1800
cagccagaa  cggaaagag  agaaggcca  gctggccaa  ctgcagcgg  ctcgggcca  1860
ctccatgga  gggctgatg  cgcgctggg  tcctgatcg  gccttctcc  ggaccaagg  1920
ctccaaggc  ttccgccag  tgggcattg  tgattccag  aaagacaac  ggggcaccc  1980
agatgccct  aaccctgag  atgaggtgg  tgagttcct  agccgtgcc  tcgatgccc  2040
cagcattga  cagctgcgg  aggaccatg  gcgccggtt  ctgctcacc  tccagagag  2100
ggatcttga  aagaagtac  cccggaagg  ggatccccg  ttcggagcc  acgttgcct  2160
tgccctgtt  gtcttctgc  tcatctgct  catccagct  ctcatcttc  cacactcca  2220
cctgatgct  gggatctat  ccagcatct  cctgctgct  ctaatcacc  tgctgatct  2280
tgctgtgta  tcctgtggt  ctctgttcc  taaggccct  caacgtctg  cccgcagca  2340
tgtccgctc  cgggcacat  gcaccgcag  tggcatctt  tccgtcctg  ttgtgttta  2400
ttctgccat  gccaacatg  acttcatcg  gaacatgct  ctgagtctc  tggccagct  2460
tgtcttcct  cacatcagc  gcatcggga  gttggccat  atctttgtc  tggggctca  2520
ctatttggt  ctgcttctg  tgggtcccc  agccaccat  tttgacaac  atgacctac  2580
gcttggcgt  catggcttg  cttcttcca  tgagacctt  gatgggctg  actgtccag  2640
tgcagggag  gtggccctc  aatatatga  ccctgtgat  ctgctggtg  ttgcgctgg  2700
gctgtatct  catgctcag  aggtggagt  gactgcccg  ctagacttc  tctggaaac  2760
acaggcaac  ggggagaag  aggagatgg  ggagctaca  gcatacaac  ggaggctgc  2820
gcataacat  ctgcccaag  acgtggcgg  ccacttcct  gcccgggag  gccgcaatg  2880
tgaactcta  tatcagtcg  gtgagtgtg  ggctgttat  tttgcctcc  ttgccaact  2940
ctctgagtt  tatgtggag  tggaggcaa  caatgaggg  gtcgagtgc  tgcggctgc  3000
caacgagat  atcgctgac  ttgatgaga  tatcagcga  gagcggttc  ggcagctgg  3060
aaagatcaa  acgattggt  gcacctaca  ggctgcctc  gggctgaac  ccagcacct  3120
cgatcaggt  ggccgctcc  acatcactg  cctggctga  tacgccatg  ggctcatgg  3180
gcagatgaa  cacatcaat  agcactcct  caacaattt  cagatgaag  ttgggctga  3240
catgggccc  gtcgtggca  gtgtcatcg  ggctcggaa  ccacagtat  acatctggg  3300
gaacacagt  aatgtctct  gtcgtatgg  cagcacggg  gtccccgac  gaatccagg  3360
gaccacgga  ctgtaccag  ttctagctg  caagggcta  cagctggag  gtcgagggg  3420
ggtcaaggt  aagggcaag  gggagatga  cacctactt  ctcaatggg  gccccagca  3480
ttaacaggg  ccagccaca  attcagctg  agggaccaa  gtgggcatt  agtggactc  3540
gtgctcact  ggtggagct  tggcagggg  cactgagcc  ccagaccct  ctaaccaca  3600
aagggaaca  cccagcagg  tgtgcttgg  tcatgctcg  ctgccctca  gctggaaaa  3660
aaggggcta  ctaccgaga  gattatgca  gtgactttc  ttcttactt  gggtagggc  3720
gttccctct  caatcttcc  gcctttggg  gcaggggag  ggtcagtag  agaagcaga  3780
ggaggcctc  tgcctgagg  attaaaatg  cagcttgcc  tgcctaccc  tccctgtct  3840
tctgggcag  aggttcagg  ctgagccct  cttttccct  ttttttcct  ggaatattt  3900
gtacaatat  ttgtacaaa  acaggcatg  ggagtgcct  ttccatgct  gcctttgca  3960
tacctgcat  cccagcact  gtcctgggc  cttccccac  ccagccagg  gtccctcct  4020
tgcacagag  agaggaggg  gaagctctg  ggagccagc  ttggccata  ttcaggaga  4080
tgtttccat  tgccaaatc  tagtcccat  atctgtccc  aaaggggaa  aaagggacc  4140
ctgacagct  agatttagc  ccagttcct  cacgctcca  ggaacgggg  gtctggcct  4200
actggtact  tgaaaaatg  tcagagagc  agcctgtgt  tggggatgt  aggtcagga  4260
ctggaagtt  acctgcagg  gccaaagag  aggccggcc  gggctgggg  agtgccaga  4320
tctgatctg  ggaccccgt  ggggtccag  tcaggtcac  ctgccccag  gctctcttg  4380
tgtctgctg  caagggggc  tggagcatc  cttcctctt  tgttgccaa  tagaaaagg  4440
tcagggcat  gagaaaggt  accctgatc  caaacctgc  ctcccaagt  tctggtgtt  4500
gggagggcc  gtgtgtttg  gtaactgtg  gtgcatgtt  gtctttgtg  gcatatctg  4560
tttccaggt  tatgtgagt  cttgtgctc  tgctcctca  ctctccacc  caggttgcc  4620
ctctcctgt  ggcctctgt  ttctgggaa  aaagcaggg  ttcctactt  aggggatgt  4680
gagagatgc  caggttgca  aggagtggg  tggggtgtg  tagcaaaag  agggagagg  4740
gtccttttt  tgccaaatc  ctaagtgcc  ttcgggggc  atgtgtgca  catgactct  4800
cctgtctgt  gcagggacc  aagcgcttg  ttaagcccc  gtgctccat  ccagcactt  4860
aactgtctg  ggtttgatg  acagaggct  aggaatttc  tggcttccc  agatagtgt  4920
ctgggacat  gtatgcttt  gggctgggg  agcatggaa  ccctctgag  acctggata  4980
tggtactac  gggtgggga  gaggaacct  aaacttggc  ttccccagc  ttcagcctg  5040
gtctagcat  tttctagct  cccagtccc  tgtgaagcc  tgagggctg  cagaagggt  5100
aggaggttg  actctagat  cccttcctg  ctttgcctt  cttttaccc  tttccctgc  5160
acctccttg  ctctggcct  aatttgttg  tgcctcagt  tctctgtct  tacctattt  5220
agccaaagg  actagcctg  attttgctt  aagatcact  tgtcttgga  atgactaga  5280
aggcagagg  gaagggttt  cagagttgc  aggtttggg  gtggaaggg  caggcagtg  5340
acttgcccc  cctcatgcc  cttctgaca  cagctccct  tggaggcct  gtttctggg  5400
aatgcctcc  ttgggcatc  tcatgcatc  accaaatgg  ccatcaggt  cttcattag  5460
catggcaga  ggaggggaa  agacttgtt  tccagacag  aaatctact  ccctgtccc  5520
agccatatc  ctggatagg  agggatagg  agagactac  tggtgccat  gggtagggg  5580
gagggtata  gtagatcag  gtgggaaga  ctcagcctt  ggtggcttg  ctctgcttc  5640
tgccaggtg  gagggcctg  ccacaccct  gatccccgt  ccacagtgc  agccatgcc  5700
ttcccctgg  ctaccattg  ccctttcct  acccagttg  tagaggagt  aggaggtgg  5760
aggccgtgg  ctttggttt  ataatgtaa  cactgtggg  gtgggggag  atggtgaac  5820
atgtatttc  gtgaaatat  taatatatt  aaatatcaa  aaaatcaaa  tctttgt  5877



<210> 2731
<211> 1168
<212> PRT
<213> Homo sapiens
<308> O43306
<400> 2731

Met Ser Trp Phe Ser Gly Leu Leu Val Pro Lys Val Asp Glu Arg Lys 
  1               5                  10                  15
Thr Ala Trp Gly Glu Arg Asn Gly Gln Lys Arg Ser Arg Arg Arg Gly 
             20                  25                  30
Thr Arg Ala Gly Gly Phe Cys Thr Pro Arg Tyr Met Ser Cys Leu Arg 
         35                  40                  45
Asp Ala Glu Pro Pro Ser Pro Thr Pro Ala Gly Pro Pro Arg Cys Pro 
     50                  55                  60
Trp Gln Asp Asp Ala Phe Ile Arg Arg Gly Gly Pro Gly Lys Gly Lys 
 65                  70                  75                  80
Glu Leu Gly Leu Arg Ala Val Ala Leu Gly Phe Glu Asp Thr Glu Val 
                 85                  90                  95
Thr Thr Thr Ala Gly Gly Thr Ala Glu Val Ala Pro Asp Ala Val Pro 
             100                105                110
Arg Ser Gly Arg Ser Cys Trp Arg Arg Leu Val Gln Val Phe Gln Ser 
         115                120                125
Lys Gln Phe Arg Ser Ala Lys Leu Glu Arg Leu Tyr Gln Arg Tyr Phe 
     130                135                140
Phe Gln Met Asn Gln Ser Ser Leu Thr Leu Leu Met Ala Val Leu Val 
 145                150                155                160
Leu Leu Thr Ala Val Leu Leu Ala Phe His Ala Ala Pro Ala Arg Pro 
                 165                170                175
Gln Pro Ala Tyr Val Ala Leu Leu Ala Cys Ala Ala Ala Leu Phe Val 
             180                185                190
Gly Leu Met Val Val Cys Asn Arg His Ser Phe Arg Gln Asp Ser Met 
         195                200                205
Trp Val Val Ser Tyr Val Val Leu Gly Ile Leu Ala Ala Val Gln Val 
     210                215                220
Gly Gly Ala Leu Ala Ala Asp Pro Arg Ser Pro Ser Ala Gly Leu Trp 
 225                230                235                240
Cys Pro Val Phe Phe Val Tyr Ile Ala Tyr Thr Leu Leu Pro Ile Arg 
                 245                250                255
Met Arg Ala Ala Val Leu Ser Gly Leu Gly Leu Ser Thr Leu His Leu 
             260                265                270
Ile Leu Ala Trp Gln Leu Asn Arg Gly Asp Ala Phe Leu Trp Lys Gln 
         275                280                285
Leu Gly Ala Asn Val Leu Leu Phe Leu Cys Thr Asn Val Ile Gly Ile 
     290                295                300
Cys Thr His Tyr Pro Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu 
 305                310                315                320
Thr Arg Gly Tyr Ile Gln Ala Arg Leu His Leu Gln His Glu Asn Arg 
                 325                330                335
Gln Gln Glu Arg Leu Leu Leu Ser Val Leu Pro Gln His Val Ala Met 
             340                345                350
Glu Met Lys Glu Asp Ile Asn Thr Lys Lys Glu Asp Met Met Phe His 
         355                360                365
Lys Ile Tyr Ile Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp 
     370                375                380
Ile Glu Gly Phe Thr Ser Leu Ala Ser Gln Cys Thr Ala Gln Glu Leu 
 385                390                395                400
Val Met Thr Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala 
                 405                410                415
Glu Asn His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys 
             420                425                430
Val Ser Gly Leu Pro Glu Ala Arg Ala Asp His Ala His Cys Cys Val 
         435                440                445
Glu Met Gly Val Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val 
     450                455                460
Thr Gly Val Asn Val Asn Met Arg Val Gly Ile His Ser Gly Arg Val 
 465                470                475                480
His Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser 
                 485                490                495
Asn Asp Val Thr Leu Ala Asn His Met Glu Ala Gly Gly Arg Ala Gly 
             500                505                510
Arg Ile His Ile Thr Arg Ala Thr Leu Gln Tyr Leu Asn Gly Asp Tyr 
         515                520                525
Glu Val Glu Pro Gly Arg Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu 
     530                535                540
Gln His Ile Glu Thr Phe Leu Ile Leu Gly Ala Ser Gln Lys Arg Lys 
 545                550                555                560
Glu Glu Lys Ala Met Leu Ala Lys Leu Gln Arg Thr Arg Ala Asn Ser 
                 565                570                575
Met Glu Gly Leu Met Pro Arg Trp Val Pro Asp Arg Ala Phe Ser Arg 
             580                585                590
Thr Lys Asp Ser Lys Ala Phe Arg Gln Met Gly Ile Asp Asp Ser Ser 
         595                600                605
Lys Asp Asn Arg Gly Thr Gln Asp Ala Leu Asn Pro Glu Asp Glu Val 
     610                615                620
Asp Glu Phe Leu Ser Arg Ala Ile Asp Ala Arg Ser Ile Asp Gln Leu 
 625                630                635                640
Arg Lys Asp His Val Arg Arg Phe Leu Leu Thr Phe Gln Arg Glu Asp 
                 645                650                655
Leu Glu Lys Lys Tyr Ser Arg Lys Val Asp Pro Arg Phe Gly Ala Tyr 
             660                665                670
Val Ala Cys Ala Leu Leu Val Phe Cys Phe Ile Cys Phe Ile Gln Leu 
         675                680                685
Leu Ile Phe Pro His Ser Thr Leu Met Leu Gly Ile Tyr Ala Ser Ile 
     690                695                700
Phe Leu Leu Leu Leu Ile Thr Val Leu Ile Cys Ala Val Tyr Ser Cys 
 705                710                715                720
Gly Ser Leu Phe Pro Lys Ala Leu Gln Arg Leu Ser Arg Ser Ile Val 
                 725                730                735
Arg Ser Arg Ala His Ser Thr Ala Val Gly Ile Phe Ser Val Leu Leu 
             740                745                750
Val Phe Thr Ser Ala Ile Ala Asn Met Phe Thr Cys Asn His Thr Pro 
         755                760                765
Ile Arg Ser Cys Ala Ala Arg Met Leu Asn Leu Thr Pro Ala Asp Ile 
     770                775                780
Thr Ala Cys His Leu Gln Gln Leu Asn Tyr Ser Leu Gly Leu Asp Ala 
 785                790                795                800
Pro Leu Cys Glu Gly Thr Met Pro Thr Cys Ser Phe Pro Glu Tyr Phe 
                 805                810                815
Ile Gly Asn Met Leu Leu Ser Leu Leu Ala Ser Ser Val Phe Leu His 
             820                825                830
Ile Ser Ser Ile Gly Lys Leu Ala Met Ile Phe Val Leu Gly Leu Ile 
         835                840                845
Tyr Leu Val Leu Leu Leu Leu Gly Pro Pro Ala Thr Ile Phe Asp Asn 
     850                855                860
Tyr Asp Leu Leu Leu Gly Val His Gly Leu Ala Ser Ser Asn Glu Thr 
 865                870                875                880
Phe Asp Gly Leu Asp Cys Pro Ala Ala Gly Arg Val Ala Leu Lys Tyr 
                 885                890                895
Met Thr Pro Val Ile Leu Leu Val Phe Ala Leu Ala Leu Tyr Leu His 
             900                905                910
Ala Gln Gln Val Glu Ser Thr Ala Arg Leu Asp Phe Leu Trp Lys Leu 
         915                920                925
Gln Ala Thr Gly Glu Lys Glu Glu Met Glu Glu Leu Gln Ala Tyr Asn 
     930                935                940
Arg Arg Leu Leu His Asn Ile Leu Pro Lys Asp Val Ala Ala His Phe 
 945                950                955                960
Leu Ala Arg Glu Arg Arg Asn Asp Glu Leu Tyr Tyr Gln Ser Cys Glu 
                 965                970                975
Cys Val Ala Val Met Phe Ala Ser Ile Ala Asn Phe Ser Glu Phe Tyr 
             980                985                990
Val Glu Leu Glu Ala Asn Asn Glu Gly Val Glu Cys Leu Arg Leu Leu 
         995                1000                1005
Asn Glu Ile Ile Ala Asp Phe Asp Glu Ile Ile Ser Glu Glu Arg Phe 
     1010                1015                1020
Arg Gln Leu Glu Lys Ile Lys Thr Ile Gly Ser Thr Tyr Met Ala Ala 
 1025                1030                1035                1040
Ser Gly Leu Asn Ala Ser Thr Tyr Asp Gln Val Gly Arg Ser His Ile 
                 1045                1050                1055
Thr Ala Leu Ala Asp Tyr Ala Met Arg Leu Met Glu Gln Met Lys His 
             1060                1065                1070
Ile Asn Glu His Ser Phe Asn Asn Phe Gln Met Lys Ile Gly Leu Asn 
         1075                1080                1085
Met Gly Pro Val Val Ala Gly Val Ile Gly Ala Arg Lys Pro Gln Tyr 
     1090                1095                1100
Asp Ile Trp Gly Asn Thr Val Asn Val Ser Ser Arg Met Asp Ser Thr 
 1105                1110                1115                1120
Gly Val Pro Asp Arg Ile Gln Val Thr Thr Asp Leu Tyr Gln Val Leu 
                 1125                1130                1135
Ala Ala Lys Gly Tyr Gln Leu Glu Cys Arg Gly Val Val Lys Val Lys 
             1140                1145                1150
Gly Lys Gly Glu Met Thr Thr Tyr Phe Leu Asn Gly Gly Pro Ser Ser 
         1155                1160                1165



<210> 2732
<211> 481
<212> DNA
<213> Rattus norvegicus
<308> L01793
<400> 2732

catggtaga  gtcttggac  gtggtgatt  tgctcatct  accttaatg  agaggcctg  60
gttgggcat  acgttgact  aactccact  ctggtcact  actcagtat  ccaaatgtg  120
gttcatgga  gcagatact  tggttctct  aaatattga  gatcttttt  aaagagaag  180
attgtcagc  gcaccagac  cagggtggc  tgactgttt  aattctgga  tctttgctt  240
tcacccctc  attgaaacg  ataaccagc  gttgcatct  gcttctgag  aaggtagtt  300
tgatggtgg  gaccagggc  tactgaata  atattttag  ggctgggca  cgacagata  360
cacaaaaca  ttgccattt  tgtataacc  gagcagcct  tcaatatac  cctacctcc  420
ggcatttaa  gcgtttggt  aaaatgcca  agttgtgca  ttcctggga  gaaccaagc  480
a  481



<210> 2733
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> NP_112305
<400> 2733

Met Thr Asp Gln Ala Phe Val Thr Leu Thr Thr Asn Asp Ala Tyr Ala 
  1               5                  10                  15
Lys Gly Ala Leu Val Leu Gly Ser Ser Leu Lys Gln His Arg Thr Thr 
             20                  25                  30
Arg Arg Thr Val Val Leu Ala Ser Pro Gln Val Ser Asp Ser Met Arg 
         35                  40                  45
Lys Val Leu Glu Thr Val Phe Asp Glu Val Ile Met Val Asp Val Leu 
     50                  55                  60
Asp Ser Gly Asp Ser Ala His Leu Thr Leu Met Lys Arg Pro Glu Leu 
 65                  70                  75                  80
Gly Ile Thr Leu Thr Lys Leu His Cys Trp Ser Leu Thr Gln Tyr Ser 
                 85                  90                  95
Lys Cys Val Phe Met Asp Ala Asp Thr Leu Val Leu Ser Asn Ile Asp 
             100                105                110
Asp Leu Phe Glu Arg Glu Glu Leu Ser Ala Ala Pro Asp Pro Gly Trp 
         115                120                125
Pro Asp Cys Phe Asn Ser Gly Val Phe Val Tyr Gln Pro Ser Ile Glu 
     130                135                140
Thr Tyr Asn Gln Leu Leu His Leu Ala Ser Glu Gln Gly Ser Phe Asp 
 145                150                155                160
Gly Gly Asp Gln Gly Leu Leu Asn Thr Tyr Phe Ser Gly Trp Ala Thr 
                 165                170                175
Thr Asp Ile Thr Lys His Leu Pro Phe Val Tyr Asn Leu Ser Ser Leu 
             180                185                190
Ser Ile Tyr Ser Tyr Leu Pro Ala Phe Lys Ala Phe Gly Lys Asn Ala 
         195                200                205
Lys Val Val His Phe Leu Gly Arg Thr Lys Pro Trp Asn Tyr Thr Tyr 
     210                215                220
Asn Pro Gln Thr Lys Ser Val Lys Cys Glu Ser Gln Asp Pro Ile Val 
 225                230                235                240
Ser His Pro Glu Phe Leu Asn Leu Trp Trp Asp Thr Phe Thr Thr Asn 
                 245                250                255
Val Leu Pro Leu Leu Gln His His Gly Leu Val Lys Asp Ala Gly Ser 
             260                265                270
Tyr Leu Met Met Glu His Val Thr Gly Ala Leu Ser Asp Leu Ser Phe 
         275                280                285
Gly Glu Ala Pro Pro Ala Ser Gln Pro Ser Leu Ser Ser Glu Glu Arg 
     290                295                300
Lys Glu Arg Trp Glu Gln Gly Gln Ala Asp Tyr Met Gly Ala Asp Ser 
 305                310                315                320
Phe Asp Asn Ile Lys Arg Lys Leu Asp Thr Tyr Leu Gln 
                 325                330



<210> 2734
<211> 1807
<212> DNA
<213> Homo sapiens
<308> NM_004130
<400> 2734

ctctgagtc  ccaacctga  gctgccccg  ccgcctgcg  acccggcag  accatgaca  60
atcaggcct  tgtgacact  accacaaac  atgcctacg  caaaggtgc  ctggtcctg  120
gatcatctc  gaaacagca  aggaccacc  ggaggctgg  cgtgctcgc  acccctcag  180
tctcagact  catgagaaa  gttttagag  cagtctttg  tgaagtcat  atggtagat  240
tcttggaca  tggcgattc  gctcatcta  ccttaatga  gaggccaga  ttgggtgtc  300
cgctgacaa  gctccactg  tggtcgctt  cacagtatt  aaaatgtgt  ttcatggat  360
cagatactc  ggtcctagc  aatattgat  atctttttg  cagagaaga  ttgtcagca  420
caccagacc  agggtggcc  gactgcttc  attccggag  cttcgttta  cagccttca  480
ttgaaacat  caatcagct  ttgcatctt  cttctgagc  aggtagttt  gatggtggg  540
accaaggca  actgaacac  ttttttagc  gctgggcaa  aacagatat  agaaaacac  600
tgccgttta  ttataacct  agcagcatc  ctatatact  ctacctccc  gcatttaaa  660
tgtttggtg  aagtgccaa  gttgtgcat  tcctgggac  agtcaaacc  tggaattat  720
cttatgatc  caaaacaaa  agtgtcaaa  gtgaggccc  tgatcccaa  atgactcat  780
cagagtttc  catcctgtg  tggaacatc  ttaccacca  cgttttacc  ctgcttcaa  840
aatttggcc  tgtcaaaga  acctgctca  atgtaaatg  gctttcaga  ttggtctat  900
cactggctt  ctcttgtgg  ttctgtaga  aggaagatg  ctcaggagc  atatcacat  960
tgtcccttg  ggagatccc  gctatggca  agccgtttg  atcctcgga  gaacggaag  1020
aacgatggg  acagggcca  gctgattat  tgggagcag  ttcctttga  aacatcaag  1080
ggaaacttg  cacttacct  cagtagaaa  actgcattt  tctgtgaac  catccactt  1140
acaagcctt  tttctgata  ttagtatct  gagctgggt  gagaaaagt  tgttacagt  1200
gctagaggt  ttcattaaa  cttatcaga  gagaggctt  tttaggata  gaggtgaga  1260
ctgggcaaa  gttgtgaag  agcaattct  ttatatgga  agtgttctg  tttttaatc  1320
tatttagct  gtttcagaa  ttctcactt  tgttgactg  caacataca  agtaaggga  1380
actcaagat  ttaagatgg  tgtatcagt  cttaaaatc  gcagagcct  gttcaaaat  1440
agtcactcc  ttcagaagc  gacatggca  ctgttcctt  cttgcttgt  ggttgtgta  1500
ctttcacga  acctgaatt  tagaattgc  cagtgctgc  agagtgagt  agtgtaatt  1560
tcctttcag  taaagatag  ctatctcaa  actgctgag  gattcataa  catatcaac  1620
aatagcatt  acccatttt  tttcctgtc  ttagtgtct  aagatgctc  ccagttttc  1680
gtgtacagt  aggcagcat  ctaaaatgc  tttgttcag  tctggatat  tgaaaatag  1740
agtgtgttc  ctgatggtt  cctgcagtg  caccctgta  aaaaaataa  agacttatt  1800
gtgtaaa  1807



<210> 2735
<211> 349
<212> PRT
<213> Homo sapiens
<308> P46976
<400> 2735

Thr Asp Gln Ala Phe Val Thr Leu Thr Thr Asn Asp Ala Tyr Ala Lys 
  1               5                  10                  15
Gly Ala Leu Val Leu Gly Ser Ser Leu Lys Gln His Arg Thr Thr Arg 
             20                  25                  30
Arg Leu Val Val Leu Ala Thr Pro Gln Val Ser Asp Ser Met Arg Lys 
         35                  40                  45
Val Leu Glu Thr Val Phe Asp Glu Val Ile Met Val Asp Val Leu Asp 
     50                  55                  60
Ser Gly Asp Ser Ala His Leu Thr Leu Met Lys Arg Pro Glu Leu Gly 
 65                  70                  75                  80
Val Thr Leu Thr Lys Leu His Cys Trp Ser Leu Thr Gln Tyr Ser Lys 
                 85                  90                  95
Cys Val Phe Met Asp Ala Asp Thr Leu Val Leu Ala Asn Ile Asp Asp 
             100                105                110
Leu Phe Asp Arg Glu Glu Leu Ser Ala Ala Pro Asp Pro Gly Trp Pro 
         115                120                125
Asp Cys Phe Asn Ser Gly Val Phe Val Tyr Gln Pro Ser Val Glu Thr 
     130                135                140
Tyr Asn Gln Leu Leu His Leu Ala Ser Glu Gln Gly Ser Phe Asp Gly 
 145                150                155                160
Gly Asp Gln Gly Ile Leu Asn Thr Phe Phe Ser Ser Trp Ala Thr Thr 
                 165                170                175
Asp Ile Arg Lys His Leu Pro Phe Ile Tyr Asn Leu Ser Ser Ile Ser 
             180                185                190
Ile Tyr Ser Tyr Leu Pro Ala Phe Lys Val Phe Gly Ala Ser Ala Lys 
         195                200                205
Val Val His Phe Leu Gly Arg Val Lys Pro Trp Asn Tyr Thr Tyr Asp 
     210                215                220
Pro Lys Thr Lys Ser Val Lys Ser Glu Ala His Asp Pro Asn Met Thr 
 225                230                235                240
His Pro Glu Phe Leu Ile Leu Trp Trp Asn Ile Phe Thr Thr Asn Val 
                 245                250                255
Leu Pro Leu Leu Gln Gln Phe Gly Leu Val Lys Asp Thr Cys Ser Tyr 
             260                265                270
Val Asn Val Leu Ser Asp Leu Val Tyr Thr Leu Ala Phe Ser Cys Gly 
         275                280                285
Phe Cys Arg Lys Glu Asp Val Ser Gly Ala Ile Ser His Leu Ser Leu 
     290                295                300
Gly Glu Ile Pro Ala Met Ala Gln Pro Phe Val Ser Ser Glu Glu Arg 
 305                310                315                320
Lys Glu Arg Trp Glu Gln Gly Gln Ala Asp Tyr Met Gly Ala Asp Ser 
                 325                330                335
Phe Asp Asn Ile Lys Arg Lys Leu Asp Thr Tyr Leu Gln 
             340                345



<210> 2736
<211> 481
<212> DNA
<213> Rattus norvegicus
<308> L01793
<400> 2736

catggtaga  gtcttggac  gtggtgatt  tgctcatct  accttaatg  agaggcctg  60
gttgggcat  acgttgact  aactccact  ctggtcact  actcagtat  ccaaatgtg  120
gttcatgga  gcagatact  tggttctct  aaatattga  gatcttttt  aaagagaag  180
attgtcagc  gcaccagac  cagggtggc  tgactgttt  aattctgga  tctttgctt  240
tcacccctc  attgaaacg  ataaccagc  gttgcatct  gcttctgag  aaggtagtt  300
tgatggtgg  gaccagggc  tactgaata  atattttag  ggctgggca  cgacagata  360
cacaaaaca  ttgccattt  tgtataacc  gagcagcct  tcaatatac  cctacctcc  420
ggcatttaa  gcgtttggt  aaaatgcca  agttgtgca  ttcctggga  gaaccaagc  480
a  481



<210> 2737
<211> 332
<212> PRT
<213> Rattus norvegicus
<308> AAB81219
<400> 2737

Thr Asp Gln Ala Phe Val Thr Leu Thr Thr Asn Asp Ala Tyr Ala Lys 
  1               5                  10                  15
Gly Ala Leu Val Leu Gly Ser Ser Leu Lys Gln His Arg Thr Thr Arg 
             20                  25                  30
Arg Thr Val Val Leu Ala Ser Pro Gln Val Ser Asp Ser Met Arg Lys 
         35                  40                  45
Val Leu Glu Thr Val Phe Asp Glu Val Ile Met Val Asp Val Leu Asp 
     50                  55                  60
Ser Gly Asp Ser Ala His Leu Thr Leu Met Lys Arg Pro Glu Leu Gly 
 65                  70                  75                  80
Ile Thr Leu Thr Lys Leu His Cys Trp Ser Leu Thr Gln Tyr Ser Lys 
                 85                  90                  95
Cys Val Phe Met Asp Ala Asp Thr Leu Val Leu Ser Asn Ile Asp Asp 
             100                105                110
Leu Phe Glu Arg Glu Glu Leu Ser Ala Ala Pro Asp Pro Gly Trp Pro 
         115                120                125
Asp Cys Phe Asn Ser Gly Val Phe Val Tyr Gln Pro Ser Ile Glu Thr 
     130                135                140
Tyr Asn Gln Leu Leu His Leu Ala Ser Glu Gln Gly Ser Phe Asp Gly 
 145                150                155                160
Gly Asp Gln Gly Leu Leu Asn Thr Tyr Phe Ser Gly Trp Ala Thr Thr 
                 165                170                175
Asp Ile Thr Lys His Leu Pro Phe Val Tyr Asn Leu Ser Ser Leu Ser 
             180                185                190
Ile Tyr Ser Tyr Leu Pro Ala Phe Lys Ala Phe Gly Lys Asn Ala Lys 
         195                200                205
Val Val His Phe Leu Gly Arg Thr Lys Pro Trp Asn Tyr Thr Tyr Asn 
     210                215                220
Pro Gln Thr Lys Ser Val Lys Cys Glu Ser Gln Asp Pro Ile Val Ser 
 225                230                235                240
His Pro Glu Phe Leu Asn Leu Trp Trp Asp Thr Phe Thr Thr Asn Val 
                 245                250                255
Leu Pro Leu Leu Gln His His Gly Leu Val Lys Asp Ala Gly Ser Tyr 
             260                265                270
Leu Met Met Glu His Val Thr Gly Ala Leu Ser Asp Leu Ser Phe Gly 
         275                280                285
Glu Ala Pro Pro Ala Ser Gln Pro Ser Leu Ser Ser Glu Glu Arg Lys 
     290                295                300
Glu Arg Trp Glu Gln Gly Gln Ala Asp Tyr Met Gly Ala Asp Ser Phe 
 305                310                315                320
Asp Asn Ile Lys Arg Lys Leu Asp Thr Tyr Leu Gln 
                 325                330



<210> 2738
<211> 1807
<212> DNA
<213> Homo sapiens
<308> NM_004130
<400> 2738

ctctgagtc  ccaacctga  gctgccccg  ccgcctgcg  acccggcag  accatgaca  60
atcaggcct  tgtgacact  accacaaac  atgcctacg  caaaggtgc  ctggtcctg  120
gatcatctc  gaaacagca  aggaccacc  ggaggctgg  cgtgctcgc  acccctcag  180
tctcagact  catgagaaa  gttttagag  cagtctttg  tgaagtcat  atggtagat  240
tcttggaca  tggcgattc  gctcatcta  ccttaatga  gaggccaga  ttgggtgtc  300
cgctgacaa  gctccactg  tggtcgctt  cacagtatt  aaaatgtgt  ttcatggat  360
cagatactc  ggtcctagc  aatattgat  atctttttg  cagagaaga  ttgtcagca  420
caccagacc  agggtggcc  gactgcttc  attccggag  cttcgttta  cagccttca  480
ttgaaacat  caatcagct  ttgcatctt  cttctgagc  aggtagttt  gatggtggg  540
accaaggca  actgaacac  ttttttagc  gctgggcaa  aacagatat  agaaaacac  600
tgccgttta  ttataacct  agcagcatc  ctatatact  ctacctccc  gcatttaaa  660
tgtttggtg  aagtgccaa  gttgtgcat  tcctgggac  agtcaaacc  tggaattat  720
cttatgatc  caaaacaaa  agtgtcaaa  gtgaggccc  tgatcccaa  atgactcat  780
cagagtttc  catcctgtg  tggaacatc  ttaccacca  cgttttacc  ctgcttcaa  840
aatttggcc  tgtcaaaga  acctgctca  atgtaaatg  gctttcaga  ttggtctat  900
cactggctt  ctcttgtgg  ttctgtaga  aggaagatg  ctcaggagc  atatcacat  960
tgtcccttg  ggagatccc  gctatggca  agccgtttg  atcctcgga  gaacggaag  1020
aacgatggg  acagggcca  gctgattat  tgggagcag  ttcctttga  aacatcaag  1080
ggaaacttg  cacttacct  cagtagaaa  actgcattt  tctgtgaac  catccactt  1140
acaagcctt  tttctgata  ttagtatct  gagctgggt  gagaaaagt  tgttacagt  1200
gctagaggt  ttcattaaa  cttatcaga  gagaggctt  tttaggata  gaggtgaga  1260
ctgggcaaa  gttgtgaag  agcaattct  ttatatgga  agtgttctg  tttttaatc  1320
tatttagct  gtttcagaa  ttctcactt  tgttgactg  caacataca  agtaaggga  1380
actcaagat  ttaagatgg  tgtatcagt  cttaaaatc  gcagagcct  gttcaaaat  1440
agtcactcc  ttcagaagc  gacatggca  ctgttcctt  cttgcttgt  ggttgtgta  1500
ctttcacga  acctgaatt  tagaattgc  cagtgctgc  agagtgagt  agtgtaatt  1560
tcctttcag  taaagatag  ctatctcaa  actgctgag  gattcataa  catatcaac  1620
aatagcatt  acccatttt  tttcctgtc  ttagtgtct  aagatgctc  ccagttttc  1680
gtgtacagt  aggcagcat  ctaaaatgc  tttgttcag  tctggatat  tgaaaatag  1740
agtgtgttc  ctgatggtt  cctgcagtg  caccctgta  aaaaaataa  agacttatt  1800
gtgtaaa  1807



<210> 2739
<211> 349
<212> PRT
<213> Homo sapiens
<308> P46976
<400> 2739

Thr Asp Gln Ala Phe Val Thr Leu Thr Thr Asn Asp Ala Tyr Ala Lys 
  1               5                  10                  15
Gly Ala Leu Val Leu Gly Ser Ser Leu Lys Gln His Arg Thr Thr Arg 
             20                  25                  30
Arg Leu Val Val Leu Ala Thr Pro Gln Val Ser Asp Ser Met Arg Lys 
         35                  40                  45
Val Leu Glu Thr Val Phe Asp Glu Val Ile Met Val Asp Val Leu Asp 
     50                  55                  60
Ser Gly Asp Ser Ala His Leu Thr Leu Met Lys Arg Pro Glu Leu Gly 
 65                  70                  75                  80
Val Thr Leu Thr Lys Leu His Cys Trp Ser Leu Thr Gln Tyr Ser Lys 
                 85                  90                  95
Cys Val Phe Met Asp Ala Asp Thr Leu Val Leu Ala Asn Ile Asp Asp 
             100                105                110
Leu Phe Asp Arg Glu Glu Leu Ser Ala Ala Pro Asp Pro Gly Trp Pro 
         115                120                125
Asp Cys Phe Asn Ser Gly Val Phe Val Tyr Gln Pro Ser Val Glu Thr 
     130                135                140
Tyr Asn Gln Leu Leu His Leu Ala Ser Glu Gln Gly Ser Phe Asp Gly 
 145                150                155                160
Gly Asp Gln Gly Ile Leu Asn Thr Phe Phe Ser Ser Trp Ala Thr Thr 
                 165                170                175
Asp Ile Arg Lys His Leu Pro Phe Ile Tyr Asn Leu Ser Ser Ile Ser 
             180                185                190
Ile Tyr Ser Tyr Leu Pro Ala Phe Lys Val Phe Gly Ala Ser Ala Lys 
         195                200                205
Val Val His Phe Leu Gly Arg Val Lys Pro Trp Asn Tyr Thr Tyr Asp 
     210                215                220
Pro Lys Thr Lys Ser Val Lys Ser Glu Ala His Asp Pro Asn Met Thr 
 225                230                235                240
His Pro Glu Phe Leu Ile Leu Trp Trp Asn Ile Phe Thr Thr Asn Val 
                 245                250                255
Leu Pro Leu Leu Gln Gln Phe Gly Leu Val Lys Asp Thr Cys Ser Tyr 
             260                265                270
Val Asn Val Leu Ser Asp Leu Val Tyr Thr Leu Ala Phe Ser Cys Gly 
         275                280                285
Phe Cys Arg Lys Glu Asp Val Ser Gly Ala Ile Ser His Leu Ser Leu 
     290                295                300
Gly Glu Ile Pro Ala Met Ala Gln Pro Phe Val Ser Ser Glu Glu Arg 
 305                310                315                320
Lys Glu Arg Trp Glu Gln Gly Gln Ala Asp Tyr Met Gly Ala Asp Ser 
                 325                330                335
Phe Asp Asn Ile Lys Arg Lys Leu Asp Thr Tyr Leu Gln 
             340                345



<210> 2740
<211> 481
<212> DNA
<213> Rattus norvegicus
<308> L01793
<400> 2740

catggtaga  gtcttggac  gtggtgatt  tgctcatct  accttaatg  agaggcctg  60
gttgggcat  acgttgact  aactccact  ctggtcact  actcagtat  ccaaatgtg  120
gttcatgga  gcagatact  tggttctct  aaatattga  gatcttttt  aaagagaag  180
attgtcagc  gcaccagac  cagggtggc  tgactgttt  aattctgga  tctttgctt  240
tcacccctc  attgaaacg  ataaccagc  gttgcatct  gcttctgag  aaggtagtt  300
tgatggtgg  gaccagggc  tactgaata  atattttag  ggctgggca  cgacagata  360
cacaaaaca  ttgccattt  tgtataacc  gagcagcct  tcaatatac  cctacctcc  420
ggcatttaa  gcgtttggt  aaaatgcca  agttgtgca  ttcctggga  gaaccaagc  480
a  481



<210> 2741
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> NP_112305
<400> 2741

Met Thr Asp Gln Ala Phe Val Thr Leu Thr Thr Asn Asp Ala Tyr Ala 
  1               5                  10                  15
Lys Gly Ala Leu Val Leu Gly Ser Ser Leu Lys Gln His Arg Thr Thr 
             20                  25                  30
Arg Arg Thr Val Val Leu Ala Ser Pro Gln Val Ser Asp Ser Met Arg 
         35                  40                  45
Lys Val Leu Glu Thr Val Phe Asp Glu Val Ile Met Val Asp Val Leu 
     50                  55                  60
Asp Ser Gly Asp Ser Ala His Leu Thr Leu Met Lys Arg Pro Glu Leu 
 65                  70                  75                  80
Gly Ile Thr Leu Thr Lys Leu His Cys Trp Ser Leu Thr Gln Tyr Ser 
                 85                  90                  95
Lys Cys Val Phe Met Asp Ala Asp Thr Leu Val Leu Ser Asn Ile Asp 
             100                105                110
Asp Leu Phe Glu Arg Glu Glu Leu Ser Ala Ala Pro Asp Pro Gly Trp 
         115                120                125
Pro Asp Cys Phe Asn Ser Gly Val Phe Val Tyr Gln Pro Ser Ile Glu 
     130                135                140
Thr Tyr Asn Gln Leu Leu His Leu Ala Ser Glu Gln Gly Ser Phe Asp 
 145                150                155                160
Gly Gly Asp Gln Gly Leu Leu Asn Thr Tyr Phe Ser Gly Trp Ala Thr 
                 165                170                175
Thr Asp Ile Thr Lys His Leu Pro Phe Val Tyr Asn Leu Ser Ser Leu 
             180                185                190
Ser Ile Tyr Ser Tyr Leu Pro Ala Phe Lys Ala Phe Gly Lys Asn Ala 
         195                200                205
Lys Val Val His Phe Leu Gly Arg Thr Lys Pro Trp Asn Tyr Thr Tyr 
     210                215                220
Asn Pro Gln Thr Lys Ser Val Lys Cys Glu Ser Gln Asp Pro Ile Val 
 225                230                235                240
Ser His Pro Glu Phe Leu Asn Leu Trp Trp Asp Thr Phe Thr Thr Asn 
                 245                250                255
Val Leu Pro Leu Leu Gln His His Gly Leu Val Lys Asp Ala Gly Ser 
             260                265                270
Tyr Leu Met Met Glu His Val Thr Gly Ala Leu Ser Asp Leu Ser Phe 
         275                280                285
Gly Glu Ala Pro Pro Ala Ser Gln Pro Ser Leu Ser Ser Glu Glu Arg 
     290                295                300
Lys Glu Arg Trp Glu Gln Gly Gln Ala Asp Tyr Met Gly Ala Asp Ser 
 305                310                315                320
Phe Asp Asn Ile Lys Arg Lys Leu Asp Thr Tyr Leu Gln 
                 325                330



<210> 2742
<211> 1807
<212> DNA
<213> Homo sapiens
<308> NM_004130
<400> 2742

ctctgagtc  ccaacctga  gctgccccg  ccgcctgcg  acccggcag  accatgaca  60
atcaggcct  tgtgacact  accacaaac  atgcctacg  caaaggtgc  ctggtcctg  120
gatcatctc  gaaacagca  aggaccacc  ggaggctgg  cgtgctcgc  acccctcag  180
tctcagact  catgagaaa  gttttagag  cagtctttg  tgaagtcat  atggtagat  240
tcttggaca  tggcgattc  gctcatcta  ccttaatga  gaggccaga  ttgggtgtc  300
cgctgacaa  gctccactg  tggtcgctt  cacagtatt  aaaatgtgt  ttcatggat  360
cagatactc  ggtcctagc  aatattgat  atctttttg  cagagaaga  ttgtcagca  420
caccagacc  agggtggcc  gactgcttc  attccggag  cttcgttta  cagccttca  480
ttgaaacat  caatcagct  ttgcatctt  cttctgagc  aggtagttt  gatggtggg  540
accaaggca  actgaacac  ttttttagc  gctgggcaa  aacagatat  agaaaacac  600
tgccgttta  ttataacct  agcagcatc  ctatatact  ctacctccc  gcatttaaa  660
tgtttggtg  aagtgccaa  gttgtgcat  tcctgggac  agtcaaacc  tggaattat  720
cttatgatc  caaaacaaa  agtgtcaaa  gtgaggccc  tgatcccaa  atgactcat  780
cagagtttc  catcctgtg  tggaacatc  ttaccacca  cgttttacc  ctgcttcaa  840
aatttggcc  tgtcaaaga  acctgctca  atgtaaatg  gctttcaga  ttggtctat  900
cactggctt  ctcttgtgg  ttctgtaga  aggaagatg  ctcaggagc  atatcacat  960
tgtcccttg  ggagatccc  gctatggca  agccgtttg  atcctcgga  gaacggaag  1020
aacgatggg  acagggcca  gctgattat  tgggagcag  ttcctttga  aacatcaag  1080
ggaaacttg  cacttacct  cagtagaaa  actgcattt  tctgtgaac  catccactt  1140
acaagcctt  tttctgata  ttagtatct  gagctgggt  gagaaaagt  tgttacagt  1200
gctagaggt  ttcattaaa  cttatcaga  gagaggctt  tttaggata  gaggtgaga  1260
ctgggcaaa  gttgtgaag  agcaattct  ttatatgga  agtgttctg  tttttaatc  1320
tatttagct  gtttcagaa  ttctcactt  tgttgactg  caacataca  agtaaggga  1380
actcaagat  ttaagatgg  tgtatcagt  cttaaaatc  gcagagcct  gttcaaaat  1440
agtcactcc  ttcagaagc  gacatggca  ctgttcctt  cttgcttgt  ggttgtgta  1500
ctttcacga  acctgaatt  tagaattgc  cagtgctgc  agagtgagt  agtgtaatt  1560
tcctttcag  taaagatag  ctatctcaa  actgctgag  gattcataa  catatcaac  1620
aatagcatt  acccatttt  tttcctgtc  ttagtgtct  aagatgctc  ccagttttc  1680
gtgtacagt  aggcagcat  ctaaaatgc  tttgttcag  tctggatat  tgaaaatag  1740
agtgtgttc  ctgatggtt  cctgcagtg  caccctgta  aaaaaataa  agacttatt  1800
gtgtaaa  1807



<210> 2743
<211> 349
<212> PRT
<213> Homo sapiens
<308> P46976
<400> 2743

Thr Asp Gln Ala Phe Val Thr Leu Thr Thr Asn Asp Ala Tyr Ala Lys 
  1               5                  10                  15
Gly Ala Leu Val Leu Gly Ser Ser Leu Lys Gln His Arg Thr Thr Arg 
             20                  25                  30
Arg Leu Val Val Leu Ala Thr Pro Gln Val Ser Asp Ser Met Arg Lys 
         35                  40                  45
Val Leu Glu Thr Val Phe Asp Glu Val Ile Met Val Asp Val Leu Asp 
     50                  55                  60
Ser Gly Asp Ser Ala His Leu Thr Leu Met Lys Arg Pro Glu Leu Gly 
 65                  70                  75                  80
Val Thr Leu Thr Lys Leu His Cys Trp Ser Leu Thr Gln Tyr Ser Lys 
                 85                  90                  95
Cys Val Phe Met Asp Ala Asp Thr Leu Val Leu Ala Asn Ile Asp Asp 
             100                105                110
Leu Phe Asp Arg Glu Glu Leu Ser Ala Ala Pro Asp Pro Gly Trp Pro 
         115                120                125
Asp Cys Phe Asn Ser Gly Val Phe Val Tyr Gln Pro Ser Val Glu Thr 
     130                135                140
Tyr Asn Gln Leu Leu His Leu Ala Ser Glu Gln Gly Ser Phe Asp Gly 
 145                150                155                160
Gly Asp Gln Gly Ile Leu Asn Thr Phe Phe Ser Ser Trp Ala Thr Thr 
                 165                170                175
Asp Ile Arg Lys His Leu Pro Phe Ile Tyr Asn Leu Ser Ser Ile Ser 
             180                185                190
Ile Tyr Ser Tyr Leu Pro Ala Phe Lys Val Phe Gly Ala Ser Ala Lys 
         195                200                205
Val Val His Phe Leu Gly Arg Val Lys Pro Trp Asn Tyr Thr Tyr Asp 
     210                215                220
Pro Lys Thr Lys Ser Val Lys Ser Glu Ala His Asp Pro Asn Met Thr 
 225                230                235                240
His Pro Glu Phe Leu Ile Leu Trp Trp Asn Ile Phe Thr Thr Asn Val 
                 245                250                255
Leu Pro Leu Leu Gln Gln Phe Gly Leu Val Lys Asp Thr Cys Ser Tyr 
             260                265                270
Val Asn Val Leu Ser Asp Leu Val Tyr Thr Leu Ala Phe Ser Cys Gly 
         275                280                285
Phe Cys Arg Lys Glu Asp Val Ser Gly Ala Ile Ser His Leu Ser Leu 
     290                295                300
Gly Glu Ile Pro Ala Met Ala Gln Pro Phe Val Ser Ser Glu Glu Arg 
 305                310                315                320
Lys Glu Arg Trp Glu Gln Gly Gln Ala Asp Tyr Met Gly Ala Asp Ser 
                 325                330                335
Phe Asp Asn Ile Lys Arg Lys Leu Asp Thr Tyr Leu Gln 
             340                345



<210> 2744
<211> 481
<212> DNA
<213> Rattus norvegicus
<308> L01793
<400> 2744

catggtaga  gtcttggac  gtggtgatt  tgctcatct  accttaatg  agaggcctg  60
gttgggcat  acgttgact  aactccact  ctggtcact  actcagtat  ccaaatgtg  120
gttcatgga  gcagatact  tggttctct  aaatattga  gatcttttt  aaagagaag  180
attgtcagc  gcaccagac  cagggtggc  tgactgttt  aattctgga  tctttgctt  240
tcacccctc  attgaaacg  ataaccagc  gttgcatct  gcttctgag  aaggtagtt  300
tgatggtgg  gaccagggc  tactgaata  atattttag  ggctgggca  cgacagata  360
cacaaaaca  ttgccattt  tgtataacc  gagcagcct  tcaatatac  cctacctcc  420
ggcatttaa  gcgtttggt  aaaatgcca  agttgtgca  ttcctggga  gaaccaagc  480
a  481



<210> 2745
<211> 332
<212> PRT
<213> Rattus norvegicus
<308> AAB81219
<400> 2745

Thr Asp Gln Ala Phe Val Thr Leu Thr Thr Asn Asp Ala Tyr Ala Lys 
  1               5                  10                  15
Gly Ala Leu Val Leu Gly Ser Ser Leu Lys Gln His Arg Thr Thr Arg 
             20                  25                  30
Arg Thr Val Val Leu Ala Ser Pro Gln Val Ser Asp Ser Met Arg Lys 
         35                  40                  45
Val Leu Glu Thr Val Phe Asp Glu Val Ile Met Val Asp Val Leu Asp 
     50                  55                  60
Ser Gly Asp Ser Ala His Leu Thr Leu Met Lys Arg Pro Glu Leu Gly 
 65                  70                  75                  80
Ile Thr Leu Thr Lys Leu His Cys Trp Ser Leu Thr Gln Tyr Ser Lys 
                 85                  90                  95
Cys Val Phe Met Asp Ala Asp Thr Leu Val Leu Ser Asn Ile Asp Asp 
             100                105                110
Leu Phe Glu Arg Glu Glu Leu Ser Ala Ala Pro Asp Pro Gly Trp Pro 
         115                120                125
Asp Cys Phe Asn Ser Gly Val Phe Val Tyr Gln Pro Ser Ile Glu Thr 
     130                135                140
Tyr Asn Gln Leu Leu His Leu Ala Ser Glu Gln Gly Ser Phe Asp Gly 
 145                150                155                160
Gly Asp Gln Gly Leu Leu Asn Thr Tyr Phe Ser Gly Trp Ala Thr Thr 
                 165                170                175
Asp Ile Thr Lys His Leu Pro Phe Val Tyr Asn Leu Ser Ser Leu Ser 
             180                185                190
Ile Tyr Ser Tyr Leu Pro Ala Phe Lys Ala Phe Gly Lys Asn Ala Lys 
         195                200                205
Val Val His Phe Leu Gly Arg Thr Lys Pro Trp Asn Tyr Thr Tyr Asn 
     210                215                220
Pro Gln Thr Lys Ser Val Lys Cys Glu Ser Gln Asp Pro Ile Val Ser 
 225                230                235                240
His Pro Glu Phe Leu Asn Leu Trp Trp Asp Thr Phe Thr Thr Asn Val 
                 245                250                255
Leu Pro Leu Leu Gln His His Gly Leu Val Lys Asp Ala Gly Ser Tyr 
             260                265                270
Leu Met Met Glu His Val Thr Gly Ala Leu Ser Asp Leu Ser Phe Gly 
         275                280                285
Glu Ala Pro Pro Ala Ser Gln Pro Ser Leu Ser Ser Glu Glu Arg Lys 
     290                295                300
Glu Arg Trp Glu Gln Gly Gln Ala Asp Tyr Met Gly Ala Asp Ser Phe 
 305                310                315                320
Asp Asn Ile Lys Arg Lys Leu Asp Thr Tyr Leu Gln 
                 325                330



<210> 2746
<211> 1807
<212> DNA
<213> Homo sapiens
<308> NM_004130
<400> 2746

ctctgagtc  ccaacctga  gctgccccg  ccgcctgcg  acccggcag  accatgaca  60
atcaggcct  tgtgacact  accacaaac  atgcctacg  caaaggtgc  ctggtcctg  120
gatcatctc  gaaacagca  aggaccacc  ggaggctgg  cgtgctcgc  acccctcag  180
tctcagact  catgagaaa  gttttagag  cagtctttg  tgaagtcat  atggtagat  240
tcttggaca  tggcgattc  gctcatcta  ccttaatga  gaggccaga  ttgggtgtc  300
cgctgacaa  gctccactg  tggtcgctt  cacagtatt  aaaatgtgt  ttcatggat  360
cagatactc  ggtcctagc  aatattgat  atctttttg  cagagaaga  ttgtcagca  420
caccagacc  agggtggcc  gactgcttc  attccggag  cttcgttta  cagccttca  480
ttgaaacat  caatcagct  ttgcatctt  cttctgagc  aggtagttt  gatggtggg  540
accaaggca  actgaacac  ttttttagc  gctgggcaa  aacagatat  agaaaacac  600
tgccgttta  ttataacct  agcagcatc  ctatatact  ctacctccc  gcatttaaa  660
tgtttggtg  aagtgccaa  gttgtgcat  tcctgggac  agtcaaacc  tggaattat  720
cttatgatc  caaaacaaa  agtgtcaaa  gtgaggccc  tgatcccaa  atgactcat  780
cagagtttc  catcctgtg  tggaacatc  ttaccacca  cgttttacc  ctgcttcaa  840
aatttggcc  tgtcaaaga  acctgctca  atgtaaatg  gctttcaga  ttggtctat  900
cactggctt  ctcttgtgg  ttctgtaga  aggaagatg  ctcaggagc  atatcacat  960
tgtcccttg  ggagatccc  gctatggca  agccgtttg  atcctcgga  gaacggaag  1020
aacgatggg  acagggcca  gctgattat  tgggagcag  ttcctttga  aacatcaag  1080
ggaaacttg  cacttacct  cagtagaaa  actgcattt  tctgtgaac  catccactt  1140
acaagcctt  tttctgata  ttagtatct  gagctgggt  gagaaaagt  tgttacagt  1200
gctagaggt  ttcattaaa  cttatcaga  gagaggctt  tttaggata  gaggtgaga  1260
ctgggcaaa  gttgtgaag  agcaattct  ttatatgga  agtgttctg  tttttaatc  1320
tatttagct  gtttcagaa  ttctcactt  tgttgactg  caacataca  agtaaggga  1380
actcaagat  ttaagatgg  tgtatcagt  cttaaaatc  gcagagcct  gttcaaaat  1440
agtcactcc  ttcagaagc  gacatggca  ctgttcctt  cttgcttgt  ggttgtgta  1500
ctttcacga  acctgaatt  tagaattgc  cagtgctgc  agagtgagt  agtgtaatt  1560
tcctttcag  taaagatag  ctatctcaa  actgctgag  gattcataa  catatcaac  1620
aatagcatt  acccatttt  tttcctgtc  ttagtgtct  aagatgctc  ccagttttc  1680
gtgtacagt  aggcagcat  ctaaaatgc  tttgttcag  tctggatat  tgaaaatag  1740
agtgtgttc  ctgatggtt  cctgcagtg  caccctgta  aaaaaataa  agacttatt  1800
gtgtaaa  1807



<210> 2747
<211> 349
<212> PRT
<213> Homo sapiens
<308> P46976
<400> 2747

Thr Asp Gln Ala Phe Val Thr Leu Thr Thr Asn Asp Ala Tyr Ala Lys 
  1               5                  10                  15
Gly Ala Leu Val Leu Gly Ser Ser Leu Lys Gln His Arg Thr Thr Arg 
             20                  25                  30
Arg Leu Val Val Leu Ala Thr Pro Gln Val Ser Asp Ser Met Arg Lys 
         35                  40                  45
Val Leu Glu Thr Val Phe Asp Glu Val Ile Met Val Asp Val Leu Asp 
     50                  55                  60
Ser Gly Asp Ser Ala His Leu Thr Leu Met Lys Arg Pro Glu Leu Gly 
 65                  70                  75                  80
Val Thr Leu Thr Lys Leu His Cys Trp Ser Leu Thr Gln Tyr Ser Lys 
                 85                  90                  95
Cys Val Phe Met Asp Ala Asp Thr Leu Val Leu Ala Asn Ile Asp Asp 
             100                105                110
Leu Phe Asp Arg Glu Glu Leu Ser Ala Ala Pro Asp Pro Gly Trp Pro 
         115                120                125
Asp Cys Phe Asn Ser Gly Val Phe Val Tyr Gln Pro Ser Val Glu Thr 
     130                135                140
Tyr Asn Gln Leu Leu His Leu Ala Ser Glu Gln Gly Ser Phe Asp Gly 
 145                150                155                160
Gly Asp Gln Gly Ile Leu Asn Thr Phe Phe Ser Ser Trp Ala Thr Thr 
                 165                170                175
Asp Ile Arg Lys His Leu Pro Phe Ile Tyr Asn Leu Ser Ser Ile Ser 
             180                185                190
Ile Tyr Ser Tyr Leu Pro Ala Phe Lys Val Phe Gly Ala Ser Ala Lys 
         195                200                205
Val Val His Phe Leu Gly Arg Val Lys Pro Trp Asn Tyr Thr Tyr Asp 
     210                215                220
Pro Lys Thr Lys Ser Val Lys Ser Glu Ala His Asp Pro Asn Met Thr 
 225                230                235                240
His Pro Glu Phe Leu Ile Leu Trp Trp Asn Ile Phe Thr Thr Asn Val 
                 245                250                255
Leu Pro Leu Leu Gln Gln Phe Gly Leu Val Lys Asp Thr Cys Ser Tyr 
             260                265                270
Val Asn Val Leu Ser Asp Leu Val Tyr Thr Leu Ala Phe Ser Cys Gly 
         275                280                285
Phe Cys Arg Lys Glu Asp Val Ser Gly Ala Ile Ser His Leu Ser Leu 
     290                295                300
Gly Glu Ile Pro Ala Met Ala Gln Pro Phe Val Ser Ser Glu Glu Arg 
 305                310                315                320
Lys Glu Arg Trp Glu Gln Gly Gln Ala Asp Tyr Met Gly Ala Asp Ser 
                 325                330                335
Phe Asp Asn Ile Lys Arg Lys Leu Asp Thr Tyr Leu Gln 
             340                345



<210> 2748
<211> 3829
<212> DNA
<213> Rattus norvegicus
<308> L02315
<400> 2748

cgggtgctc  ccccacccc  cgagggggg  ggggagcgc  tcggcccct  taaggtgcg  60
cgctcggcg  agtgcgggc  ggcggcccg  gagccggcg  ggggccagg  gccgggtag  120
gaagtcctg  ctccccctc  gcccgcacc  gcccgcgcc  tccgcccac  gcgccgcga  180
ggccatgcg  cgcctctga  ccatgtcgt  ctcctacgc  aagaacggg  cggcggacg  240
gccgcactc  cccagctcg  aggtggccc  aggcaccac  acccggagg  gcaggttga  300
aagatccga  ggcagcacc  cttccacca  cttcatcct  agacagggg  cagcagatt  360
ctatacaag  aggccatcg  actccgatg  ctctttgga  gaggaccgg  aagcgattc  420
gcaagagag  gaacagcaa  cagctatcc  gcttgagag  gcgaagtcc  aacctgtag  480
ttttgcggt  aaaacgaat  tgagctact  tggtgccct  gatgaggat  tgcccgttc  540
cagcacagc  atctccttt  acgccaagg  ctttcttca  attaaagag  aatataaca  600
tgattggtg  ataggaagg  tggtgaagg  gggctgtga  atcggcttc  tcccaagtc  660
actgcgttt  gagaacata  ggattcaac  ggaacagaa  agaggccgt  ttcatggcg  720
gaaatcgag  ggaaactct  cctccagtc  gggagaaat  gtgtcagga  catttcgag  780
aactcccac  acaacagca  aacagaagc  gaaagtgac  gagcacatt  ctccgtatg  840
tgttgtgcc  tcaatgcgt  ctgtggtgt  agtagggcc  tcactgaaa  gttatgagg  900
aacagacat  atgcagaaa  ccctctttg  tttcctgaa  cacaggttt  atgggagga  960
atcaataac  agagtgaca  ctgacattt  tcttgctaa  aggtctgtc  tcaacaatc  1020
tagcaagag  gcaataatt  aacgttcaa  caccagatc  agcctagcg  aagtacaga  1080
tgaaattga  agaattttc  agttggcaa  atctttgca  ttggttgtt  tcgatgcag  1140
caccatcaa  cacccagca  agctgataa  gacatcgtt  gcgcccatc  tcgtccacg  1200
gaaggtctc  tccccaaag  ttttacagc  gctgattaa  tccagagga  agtcccaga  1260
taaacactt  aatgttcaa  tggtggcag  tgataaact  gcccagtgt  cccctgaaa  1320
gtttgatgt  atattagat  agaatcaac  tgaggatgc  tgtgaacat  tgggagagt  1380
cctggaggc  tattggcgt  ccacccaca  aagcagtag  acccctatg  ccccattgc  1440
ggggaggaa  gtgggctcc  cagctctct  accgtatcc  acagcaatc  ctggactac  1500
gagtcagcg  atgaggcat  gcaaccact  tacagagaa  tctccaatt  aaagacgaa  1560
cctaatgac  tctgatgaa  attaccaca  tgagagggc  cgcaagagt  ggaaccgct  1620
gtcctccag  tcccagcac  gccgagatc  ctaccctct  gtggaagaa  attatcctg  1680
ctcatacca  gacacttac  aaccccata  gaaccgagg  tcacctggg  gatgcagcc  1740
tgactcccg  cataggctt  gaggctgcc  aaacaaaca  acaaacaaa  aaacatcat  1800
tgttgacaa  ttgccatag  actgctaag  taaaccagt  atcttaatt  ggcaagcat  1860
gcacagtat  tgctgtgcg  gtggtctgc  gtcgtttga  gtaaggggc  agaattaaa  1920
agaagtaca  tatgccctt  agtctagga  ggtattaga  acccggtca  ataggtatt  1980
ttaagtgct  catttacat  ataacagta  cttttgttt  cttcataga  tttagacac  2040
tcaatttgt  atttagggt  ctgatcaag  cacatataa  ataatttcc  gtgtaggaa  2100
ttccaaatg  ccagttcca  ttggaacca  tttataaac  aattcctgt  ggaatttgg  2160
tgaattgac  ggaaagtct  cctgagcat  ttgaaatca  ttgaaaaaa  cagagaaga  2220
aaaaatacc  aataaggaa  tcaaaatac  aatagaaac  aaacccagc  atggtattt  2280
tttgctgga  gctaaattt  cacttcaag  tggaatgta  aaacatttt  ataatgttg  2340
tggaatggc  tttcaaact  accaaatat  ttgatagtg  caaaaaaaa  tctcagaaa  2400
cttaatgca  aaattatat  atcgcctca  attttaata  ttttatttt  cctgatata  2460
ctgttgtat  caaagtgtt  tgccttctg  tcagtcagt  ctgttagcc  gtttgaagt  2520
gacaaaatc  aggggatat  tgagaagtg  taaagagaa  ccctagcat  gacagttcc  2580
gagagtgga  aatgaggtg  tgttccttc  gcagtcagt  tgcacacag  tgcacacat  2640
tggagacct  gtgtcaggt  gcagagatg  ggcggggcc  ctctggcta  aacggtaat  2700
ggcttcaga  gggaagtcg  ccatcgtac  gcacaccga  acgggctta  gagctgtgc  2760
agcatggct  agtgtcttt  cctcacttc  gccagtctc  atctttgaa  ataatgaat  2820
ttttggccc  gcatcacac  tcttttatg  ttcatgggc  taatcaaat  aggtactga  2880
agttatgtt  tcacaaaat  attaggaaa  cttaaaaca  tgaattaaa  tcttgcaga  2940
aaagaaaaa  aaaccctca  agaatcaga  tatatttat  cactaaaag  aagacagtt  3000
caatacacg  cattagaga  agttgagag  ctgctcggt  ccattgata  tgaacagcc  3060
ttagacttc  atgagtgta  ttatggaat  gatgaccta  gtcctatgt  attaaagac  3120
gctttaatc  aagaaatta  tgaaattga  cctttgaaa  aaatgtctt  ctgaaaggg  3180
ttgtttctg  aatgacgca  tacatgtgt  ttctaaaga  ccaattgga  ctagacgta  3240
agtctcttt  tactaatgc  ttgaagtca  tttccgaaa  aagtataat  aatagtatg  3300
taatttctc  aaaaaaaag  catgggtcc  caaaactgt  taccagttc  ttaattctc  3360
tgatcaaga  tctaagttt  atattctta  tcagttatc  tatctcgga  cccatcaac  3420
cattgtctt  actgtatgt  caacccatt  tgaacctgc  tatctgata  tgaggctgc  3480
tgaaatttt  tggtaatct  aaacatttg  tacatttaa  cacgggctc  gtcaaattg  3540
caagctaac  tctgacact  gcttgtgaa  cttttttgt  atccagcga  gcttacaga  3600
ttttctgtt  agacattta  cagagctgt  ttcattggg  tctttaata  gcatataat  3660
ttccattac  aaatacttt  ttagaagac  gaagagcat  tttccagcg  acaaactat  3720
tttattaca  gtatagcac  tatttgcat  agaaagaaa  acattagcc  aacattttc  3780
tgtatgctt  actggtttc  tgtttgtgc  cattaaagc  tttaattgc  3829



<210> 2749
<211> 2034
<212> DNA
<213> Homo sapiens
<308> AF038852
<400> 2749

agaacggga  cgcggacgg  ccgcactcc  ccacctcgc  ggtggcccg  ggcaccaca  60
cccggagga  caggttgaa  agatccgat  gcagcacca  ttcgaccag  ttcatcctc  120
gacagggtt  agcggattc  tacacaagc  ggccgtctg  ctccgatgt  tctttggaa  180
aggaccggg  agcaattcg  caggagaga  aacagcaag  agctatcca  cttgagaga  240
caaagtcca  acctgtagc  tttgccgtg  agacaaatg  gagctactg  ggcgccctg  300
acgaggatg  gcctgttcc  agcacagct  tctcctttg  tgctaaaga  tttctacat  360
ttaaagaga  atataacaa  gattggtgg  taggaaggc  ggtgaaaga  ggctgtgaa  420
ttggcttca  tccaagtcc  ctcagattg  agaacatac  gatccagca  gaacaaaaa  480
gaggacgtt  tcacggagg  aaatcaagt  gaaattctt  ttcaagtct  ggagaaatg  540
tatctggga  attccgagc  actcccaca  caacagcaa  acagaagca  aaagtgacg  600
agcacattc  tccttacga  gttgtaccg  caatgcgtc  ggtggtgtt  gtggggccg  660
cactgaaag  ttacgaggt  acagacatg  tgcagaaag  cctctttga  ttcctgaag  720
acaggtttg  tgggaggat  tcaataacg  gagtgacag  tgacatttc  cttgctaag  780
ggtctgtcc  aaataatcc  agcaagaga  caataattg  acgttcgaa  acccggtcc  840
gcttagcgg  agtacaaag  gaaattgaa  gaatctttg  gttggcaag  tctttgcaa  900
tggttgttc  tgatgcaga  accatcaat  acccagcac  acttataaa  acttcctta  960
caccaatta  tgttcatgt  aaagtctca  ctccaaagg  tttacagcg  ttgattaaa  1020
ctagaggaa  gtcacaaag  aaacacttg  atgttcaac  ggtggcagc  gataaactt  1080
cacaatgcc  cccagaaat  tttgatgtt  tattggatg  aaatcagct  gaggatgca  1140
gtgaacatc  aggggagta  ctggaggcg  actggcgtg  cacccacac  accagtagc  1200
cacccatga  cccgctgct  ggaaggaat  tgggctcca  ggcactctc  ccatatccc  1260
cagcaattt  tgggttaca  agtcagcga  tgaggcaca  caaccactc  acagagaac  1320
ctccaattg  aagacgaag  ctaatgacc  ctgatgaaa  ttatcacaa  gaaagggct  1380
ggaagagta  gaaccgctt  tcttccagt  ctcagcata  ccgagatca  taccctctt  1440
tggaagaag  ttaccctga  tcataccag  acacttaca  accccatag  aaccgagga  1500
cacctgggg  atatagcca  gactcccga  ataggcttt  agtttaatg  aacaaaaaa  1560
attcatctg  tgacaattt  ccatagcag  gctaggata  accaatcat  ttaacttgg  1620
taacatagc  cagtattta  tgtgctaat  ggctgctgt  attttatgc  aagtaaggg  1680
caaaaaaaa  aattacatt  tgcccttga  tctagatgg  tattagatg  ccgatcata  1740
agatatttt  aagtgcaac  tttacatga  aacagtaca  tttgttttc  tcatagatt  1800
agacacatc  atttgtaat  tagggtact  acaaggcac  tataaaata  tttcccatg  1860
tggaaattc  aaatgacca  ttccagttg  aaccaattt  taaaccaat  cctgttgga  1920
tttgggtga  ttgactaga  agtctactt  agcatgttg  aatcaactg  aaaatctgg  1980
gggaaaaaa  aaaaactaa  aagaaaatc  aaataccaa  agaagccaa  tcca  2034



<210> 2750
<211> 520
<212> PRT
<213> Homo sapiens
<308> O00305
<400> 2750

Met Ser Ser Ser Ser Tyr Ala Lys Asn Gly Thr Ala Asp Gly Pro His 
  1               5                  10                  15
Ser Pro Thr Ser Gln Val Ala Arg Gly Thr Thr Thr Arg Arg Ser Arg 
             20                  25                  30
Leu Lys Arg Ser Asp Gly Ser Thr Thr Ser Thr Ser Phe Ile Leu Arg 
         35                  40                  45
Gln Gly Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val 
     50                  55                  60
Ser Leu Glu Glu Asp Arg Glu Ala Ile Arg Gln Glu Arg Glu Gln Gln 
 65                  70                  75                  80
Ala Ala Ile Gln Leu Glu Arg Ala Lys Ser Lys Pro Val Ala Phe Ala 
                 85                  90                  95
Val Lys Thr Asn Val Ser Tyr Cys Gly Ala Leu Asp Glu Asp Val Pro 
             100                105                110
Val Pro Ser Thr Ala Ile Ser Phe Asp Ala Lys Asp Phe Leu His Ile 
         115                120                125
Lys Glu Lys Tyr Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu 
     130                135                140
Gly Cys Glu Ile Gly Phe Ile Pro Ser Pro Leu Arg Leu Glu Asn Ile 
 145                150                155                160
Arg Ile Gln Gln Glu Gln Lys Arg Gly Arg Phe His Gly Gly Lys Ser 
                 165                170                175
Ser Gly Asn Ser Ser Ser Ser Leu Gly Glu Met Val Ser Gly Thr Phe 
             180                185                190
Arg Ala Thr Pro Thr Ser Thr Ala Lys Gln Lys Gln Lys Val Thr Glu 
         195                200                205
His Ile Pro Pro Tyr Asp Val Val Pro Ser Met Arg Pro Val Val Leu 
     210                215                220
Val Gly Pro Ser Leu Lys Gly Tyr Glu Val Thr Asp Met Met Gln Lys 
 225                230                235                240
Ala Leu Phe Asp Ser Leu Lys His Arg Phe Asp Gly Arg Ile Ser Ile 
                 245                250                255
Thr Arg Val Thr Ala Asp Ile Ser Leu Ala Lys Arg Ser Val Leu Asn 
             260                265                270
Asn Pro Ser Lys Arg Ala Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser 
         275                280                285
Leu Ala Glu Val Gln Ser Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg 
     290                295                300
Ser Leu Gln Leu Val Val Leu Asp Ala Asp Thr Ile Asn His Pro Ala 
 305                310                315                320
Gln Leu Ile Lys Thr Ser Leu Ala Pro Ile Ile Val His Val Lys Val 
                 325                330                335
Ser Ser Pro Lys Val Leu Gln Arg Leu Ile Lys Ser Arg Gly Lys Ser 
             340                345                350
Gln Ser Lys His Leu Asn Val Gln Leu Val Ala Ala Asp Lys Leu Ala 
         355                360                365
Gln Cys Pro Pro Glu Met Phe Asp Val Ile Leu Asp Glu Asn Gln Leu 
     370                375                380
Glu Asp Ala Cys Glu His Leu Gly Glu Tyr Leu Glu Ala Tyr Trp Arg 
 385                390                395                400
Ala Thr His Thr Thr Ser Ser Thr Pro Met Thr Pro Leu Leu Gly Arg 
                 405                410                415
Asn Leu Gly Ser Thr Ala Leu Ser Pro Tyr Pro Thr Ala Ile Ser Gly 
             420                425                430
Leu Gln Ser Gln Arg Met Arg His Ser Asn His Ser Thr Glu Asn Ser 
         435                440                445
Pro Ile Glu Arg Arg Ser Leu Met Thr Ser Asp Glu Asn Tyr His Asn 
     450                455                460
Glu Arg Ala Arg Lys Ser Arg Asn Arg Leu Ser Ser Ser Ser Gln His 
 465                470                475                480
Ser Arg Asp His Tyr Pro Leu Val Glu Glu Asp Tyr Pro Asp Ser Tyr 
                 485                490                495
Gln Asp Thr Tyr Lys Pro His Arg Asn Arg Gly Ser Pro Gly Gly Tyr 
             500                505                510
Ser His Asp Ser Arg His Arg Leu 
         515                520



<210> 2751
<211> 3829
<212> DNA
<213> Rattus norvegicus
<308> L02315
<400> 2751

cgggtgctc  ccccacccc  cgagggggg  ggggagcgc  tcggcccct  taaggtgcg  60
cgctcggcg  agtgcgggc  ggcggcccg  gagccggcg  ggggccagg  gccgggtag  120
gaagtcctg  ctccccctc  gcccgcacc  gcccgcgcc  tccgcccac  gcgccgcga  180
ggccatgcg  cgcctctga  ccatgtcgt  ctcctacgc  aagaacggg  cggcggacg  240
gccgcactc  cccagctcg  aggtggccc  aggcaccac  acccggagg  gcaggttga  300
aagatccga  ggcagcacc  cttccacca  cttcatcct  agacagggg  cagcagatt  360
ctatacaag  aggccatcg  actccgatg  ctctttgga  gaggaccgg  aagcgattc  420
gcaagagag  gaacagcaa  cagctatcc  gcttgagag  gcgaagtcc  aacctgtag  480
ttttgcggt  aaaacgaat  tgagctact  tggtgccct  gatgaggat  tgcccgttc  540
cagcacagc  atctccttt  acgccaagg  ctttcttca  attaaagag  aatataaca  600
tgattggtg  ataggaagg  tggtgaagg  gggctgtga  atcggcttc  tcccaagtc  660
actgcgttt  gagaacata  ggattcaac  ggaacagaa  agaggccgt  ttcatggcg  720
gaaatcgag  ggaaactct  cctccagtc  gggagaaat  gtgtcagga  catttcgag  780
aactcccac  acaacagca  aacagaagc  gaaagtgac  gagcacatt  ctccgtatg  840
tgttgtgcc  tcaatgcgt  ctgtggtgt  agtagggcc  tcactgaaa  gttatgagg  900
aacagacat  atgcagaaa  ccctctttg  tttcctgaa  cacaggttt  atgggagga  960
atcaataac  agagtgaca  ctgacattt  tcttgctaa  aggtctgtc  tcaacaatc  1020
tagcaagag  gcaataatt  aacgttcaa  caccagatc  agcctagcg  aagtacaga  1080
tgaaattga  agaattttc  agttggcaa  atctttgca  ttggttgtt  tcgatgcag  1140
caccatcaa  cacccagca  agctgataa  gacatcgtt  gcgcccatc  tcgtccacg  1200
gaaggtctc  tccccaaag  ttttacagc  gctgattaa  tccagagga  agtcccaga  1260
taaacactt  aatgttcaa  tggtggcag  tgataaact  gcccagtgt  cccctgaaa  1320
gtttgatgt  atattagat  agaatcaac  tgaggatgc  tgtgaacat  tgggagagt  1380
cctggaggc  tattggcgt  ccacccaca  aagcagtag  acccctatg  ccccattgc  1440
ggggaggaa  gtgggctcc  cagctctct  accgtatcc  acagcaatc  ctggactac  1500
gagtcagcg  atgaggcat  gcaaccact  tacagagaa  tctccaatt  aaagacgaa  1560
cctaatgac  tctgatgaa  attaccaca  tgagagggc  cgcaagagt  ggaaccgct  1620
gtcctccag  tcccagcac  gccgagatc  ctaccctct  gtggaagaa  attatcctg  1680
ctcatacca  gacacttac  aaccccata  gaaccgagg  tcacctggg  gatgcagcc  1740
tgactcccg  cataggctt  gaggctgcc  aaacaaaca  acaaacaaa  aaacatcat  1800
tgttgacaa  ttgccatag  actgctaag  taaaccagt  atcttaatt  ggcaagcat  1860
gcacagtat  tgctgtgcg  gtggtctgc  gtcgtttga  gtaaggggc  agaattaaa  1920
agaagtaca  tatgccctt  agtctagga  ggtattaga  acccggtca  ataggtatt  1980
ttaagtgct  catttacat  ataacagta  cttttgttt  cttcataga  tttagacac  2040
tcaatttgt  atttagggt  ctgatcaag  cacatataa  ataatttcc  gtgtaggaa  2100
ttccaaatg  ccagttcca  ttggaacca  tttataaac  aattcctgt  ggaatttgg  2160
tgaattgac  ggaaagtct  cctgagcat  ttgaaatca  ttgaaaaaa  cagagaaga  2220
aaaaatacc  aataaggaa  tcaaaatac  aatagaaac  aaacccagc  atggtattt  2280
tttgctgga  gctaaattt  cacttcaag  tggaatgta  aaacatttt  ataatgttg  2340
tggaatggc  tttcaaact  accaaatat  ttgatagtg  caaaaaaaa  tctcagaaa  2400
cttaatgca  aaattatat  atcgcctca  attttaata  ttttatttt  cctgatata  2460
ctgttgtat  caaagtgtt  tgccttctg  tcagtcagt  ctgttagcc  gtttgaagt  2520
gacaaaatc  aggggatat  tgagaagtg  taaagagaa  ccctagcat  gacagttcc  2580
gagagtgga  aatgaggtg  tgttccttc  gcagtcagt  tgcacacag  tgcacacat  2640
tggagacct  gtgtcaggt  gcagagatg  ggcggggcc  ctctggcta  aacggtaat  2700
ggcttcaga  gggaagtcg  ccatcgtac  gcacaccga  acgggctta  gagctgtgc  2760
agcatggct  agtgtcttt  cctcacttc  gccagtctc  atctttgaa  ataatgaat  2820
ttttggccc  gcatcacac  tcttttatg  ttcatgggc  taatcaaat  aggtactga  2880
agttatgtt  tcacaaaat  attaggaaa  cttaaaaca  tgaattaaa  tcttgcaga  2940
aaagaaaaa  aaaccctca  agaatcaga  tatatttat  cactaaaag  aagacagtt  3000
caatacacg  cattagaga  agttgagag  ctgctcggt  ccattgata  tgaacagcc  3060
ttagacttc  atgagtgta  ttatggaat  gatgaccta  gtcctatgt  attaaagac  3120
gctttaatc  aagaaatta  tgaaattga  cctttgaaa  aaatgtctt  ctgaaaggg  3180
ttgtttctg  aatgacgca  tacatgtgt  ttctaaaga  ccaattgga  ctagacgta  3240
agtctcttt  tactaatgc  ttgaagtca  tttccgaaa  aagtataat  aatagtatg  3300
taatttctc  aaaaaaaag  catgggtcc  caaaactgt  taccagttc  ttaattctc  3360
tgatcaaga  tctaagttt  atattctta  tcagttatc  tatctcgga  cccatcaac  3420
cattgtctt  actgtatgt  caacccatt  tgaacctgc  tatctgata  tgaggctgc  3480
tgaaatttt  tggtaatct  aaacatttg  tacatttaa  cacgggctc  gtcaaattg  3540
caagctaac  tctgacact  gcttgtgaa  cttttttgt  atccagcga  gcttacaga  3600
ttttctgtt  agacattta  cagagctgt  ttcattggg  tctttaata  gcatataat  3660
ttccattac  aaatacttt  ttagaagac  gaagagcat  tttccagcg  acaaactat  3720
tttattaca  gtatagcac  tatttgcat  agaaagaaa  acattagcc  aacattttc  3780
tgtatgctt  actggtttc  tgtttgtgc  cattaaagc  tttaattgc  3829



<210> 2752
<211> 2034
<212> DNA
<213> Homo sapiens
<308> AF038852
<400> 2752

agaacggga  cgcggacgg  ccgcactcc  ccacctcgc  ggtggcccg  ggcaccaca  60
cccggagga  caggttgaa  agatccgat  gcagcacca  ttcgaccag  ttcatcctc  120
gacagggtt  agcggattc  tacacaagc  ggccgtctg  ctccgatgt  tctttggaa  180
aggaccggg  agcaattcg  caggagaga  aacagcaag  agctatcca  cttgagaga  240
caaagtcca  acctgtagc  tttgccgtg  agacaaatg  gagctactg  ggcgccctg  300
acgaggatg  gcctgttcc  agcacagct  tctcctttg  tgctaaaga  tttctacat  360
ttaaagaga  atataacaa  gattggtgg  taggaaggc  ggtgaaaga  ggctgtgaa  420
ttggcttca  tccaagtcc  ctcagattg  agaacatac  gatccagca  gaacaaaaa  480
gaggacgtt  tcacggagg  aaatcaagt  gaaattctt  ttcaagtct  ggagaaatg  540
tatctggga  attccgagc  actcccaca  caacagcaa  acagaagca  aaagtgacg  600
agcacattc  tccttacga  gttgtaccg  caatgcgtc  ggtggtgtt  gtggggccg  660
cactgaaag  ttacgaggt  acagacatg  tgcagaaag  cctctttga  ttcctgaag  720
acaggtttg  tgggaggat  tcaataacg  gagtgacag  tgacatttc  cttgctaag  780
ggtctgtcc  aaataatcc  agcaagaga  caataattg  acgttcgaa  acccggtcc  840
gcttagcgg  agtacaaag  gaaattgaa  gaatctttg  gttggcaag  tctttgcaa  900
tggttgttc  tgatgcaga  accatcaat  acccagcac  acttataaa  acttcctta  960
caccaatta  tgttcatgt  aaagtctca  ctccaaagg  tttacagcg  ttgattaaa  1020
ctagaggaa  gtcacaaag  aaacacttg  atgttcaac  ggtggcagc  gataaactt  1080
cacaatgcc  cccagaaat  tttgatgtt  tattggatg  aaatcagct  gaggatgca  1140
gtgaacatc  aggggagta  ctggaggcg  actggcgtg  cacccacac  accagtagc  1200
cacccatga  cccgctgct  ggaaggaat  tgggctcca  ggcactctc  ccatatccc  1260
cagcaattt  tgggttaca  agtcagcga  tgaggcaca  caaccactc  acagagaac  1320
ctccaattg  aagacgaag  ctaatgacc  ctgatgaaa  ttatcacaa  gaaagggct  1380
ggaagagta  gaaccgctt  tcttccagt  ctcagcata  ccgagatca  taccctctt  1440
tggaagaag  ttaccctga  tcataccag  acacttaca  accccatag  aaccgagga  1500
cacctgggg  atatagcca  gactcccga  ataggcttt  agtttaatg  aacaaaaaa  1560
attcatctg  tgacaattt  ccatagcag  gctaggata  accaatcat  ttaacttgg  1620
taacatagc  cagtattta  tgtgctaat  ggctgctgt  attttatgc  aagtaaggg  1680
caaaaaaaa  aattacatt  tgcccttga  tctagatgg  tattagatg  ccgatcata  1740
agatatttt  aagtgcaac  tttacatga  aacagtaca  tttgttttc  tcatagatt  1800
agacacatc  atttgtaat  tagggtact  acaaggcac  tataaaata  tttcccatg  1860
tggaaattc  aaatgacca  ttccagttg  aaccaattt  taaaccaat  cctgttgga  1920
tttgggtga  ttgactaga  agtctactt  agcatgttg  aatcaactg  aaaatctgg  1980
gggaaaaaa  aaaaactaa  aagaaaatc  aaataccaa  agaagccaa  tcca  2034



<210> 2753
<211> 520
<212> PRT
<213> Homo sapiens
<308> O00305
<400> 2753

Met Ser Ser Ser Ser Tyr Ala Lys Asn Gly Thr Ala Asp Gly Pro His 
  1               5                  10                  15
Ser Pro Thr Ser Gln Val Ala Arg Gly Thr Thr Thr Arg Arg Ser Arg 
             20                  25                  30
Leu Lys Arg Ser Asp Gly Ser Thr Thr Ser Thr Ser Phe Ile Leu Arg 
         35                  40                  45
Gln Gly Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val 
     50                  55                  60
Ser Leu Glu Glu Asp Arg Glu Ala Ile Arg Gln Glu Arg Glu Gln Gln 
 65                  70                  75                  80
Ala Ala Ile Gln Leu Glu Arg Ala Lys Ser Lys Pro Val Ala Phe Ala 
                 85                  90                  95
Val Lys Thr Asn Val Ser Tyr Cys Gly Ala Leu Asp Glu Asp Val Pro 
             100                105                110
Val Pro Ser Thr Ala Ile Ser Phe Asp Ala Lys Asp Phe Leu His Ile 
         115                120                125
Lys Glu Lys Tyr Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu 
     130                135                140
Gly Cys Glu Ile Gly Phe Ile Pro Ser Pro Leu Arg Leu Glu Asn Ile 
 145                150                155                160
Arg Ile Gln Gln Glu Gln Lys Arg Gly Arg Phe His Gly Gly Lys Ser 
                 165                170                175
Ser Gly Asn Ser Ser Ser Ser Leu Gly Glu Met Val Ser Gly Thr Phe 
             180                185                190
Arg Ala Thr Pro Thr Ser Thr Ala Lys Gln Lys Gln Lys Val Thr Glu 
         195                200                205
His Ile Pro Pro Tyr Asp Val Val Pro Ser Met Arg Pro Val Val Leu 
     210                215                220
Val Gly Pro Ser Leu Lys Gly Tyr Glu Val Thr Asp Met Met Gln Lys 
 225                230                235                240
Ala Leu Phe Asp Ser Leu Lys His Arg Phe Asp Gly Arg Ile Ser Ile 
                 245                250                255
Thr Arg Val Thr Ala Asp Ile Ser Leu Ala Lys Arg Ser Val Leu Asn 
             260                265                270
Asn Pro Ser Lys Arg Ala Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser 
         275                280                285
Leu Ala Glu Val Gln Ser Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg 
     290                295                300
Ser Leu Gln Leu Val Val Leu Asp Ala Asp Thr Ile Asn His Pro Ala 
 305                310                315                320
Gln Leu Ile Lys Thr Ser Leu Ala Pro Ile Ile Val His Val Lys Val 
                 325                330                335
Ser Ser Pro Lys Val Leu Gln Arg Leu Ile Lys Ser Arg Gly Lys Ser 
             340                345                350
Gln Ser Lys His Leu Asn Val Gln Leu Val Ala Ala Asp Lys Leu Ala 
         355                360                365
Gln Cys Pro Pro Glu Met Phe Asp Val Ile Leu Asp Glu Asn Gln Leu 
     370                375                380
Glu Asp Ala Cys Glu His Leu Gly Glu Tyr Leu Glu Ala Tyr Trp Arg 
 385                390                395                400
Ala Thr His Thr Thr Ser Ser Thr Pro Met Thr Pro Leu Leu Gly Arg 
                 405                410                415
Asn Leu Gly Ser Thr Ala Leu Ser Pro Tyr Pro Thr Ala Ile Ser Gly 
             420                425                430
Leu Gln Ser Gln Arg Met Arg His Ser Asn His Ser Thr Glu Asn Ser 
         435                440                445
Pro Ile Glu Arg Arg Ser Leu Met Thr Ser Asp Glu Asn Tyr His Asn 
     450                455                460
Glu Arg Ala Arg Lys Ser Arg Asn Arg Leu Ser Ser Ser Ser Gln His 
 465                470                475                480
Ser Arg Asp His Tyr Pro Leu Val Glu Glu Asp Tyr Pro Asp Ser Tyr 
                 485                490                495
Gln Asp Thr Tyr Lys Pro His Arg Asn Arg Gly Ser Pro Gly Gly Tyr 
             500                505                510
Ser His Asp Ser Arg His Arg Leu 
         515                520



<210> 2754
<211> 1330
<212> DNA
<213> Rattus norvegicus
<308> L03201
<400> 2754

gggactctc  catgccgcc  tacggagat  gctgttttg  gtgcccctg  tgtgctctg  60
gacaatgga  caactgcag  gagacctac  ctggaccac  actgggatc  ctggaagaa  120
actcgcatg  gaaggaata  agatcagaa  gaagaagac  tacgacgtc  catctggga  180
aagaatctc  agtttataa  gcttcacaa  ctggaacat  ctatgggaa  gcattcata  240
agtgtgggc  tgaaccaca  gggagacat  acacctgaa  aagtcatag  ttatatggg  300
tctctgaga  ttcccaggc  ctggaatag  agtggcact  tcaagtcaa  ctctaatca  360
acattgccc  actctgtgg  ctggcgaga  aagggctgc  tcactaatg  gaaatacca  420
ggctcttgt  gttcctgct  ggctttcag  gccgagggg  cccttgaag  gcagctgaa  480
ctgaaaacg  ggaagctgg  gtctctcag  gctcagaac  tggtggatt  ctcaaccga  540
gaaaagtac  ggaataaag  ctgcggggg  ggcttcatg  ccgaagctt  ccagtacat  600
atcgatacg  gcatcgact  agaagcttc  tatccctac  aagccatgg  tgaaaagtg  660
ctctatgac  caaaaaatc  agctgccac  tgttcaagg  acattgagc  ccccttcgg  720
gatgaagaa  ctctgaaag  agcagtggc  actaaaggg  ctgtctctg  gggcatcga  780
gacgccagc  attcctcct  cttcctcta  caaagtggt  tctatgatg  cccctcctg  840
accgagaat  tgaatcatg  tgttctcgt  gttggctat  ggactcttg  tgggaaaga  900
tactggctt  tgaaaaaca  ttggggcct  cactttggt  atcaaggat  tattcggat  960
gcgagaaat  acaaaaatc  ctgcgggat  gctagctat  gctcttacc  agaaatcta  1020
accgtttct  ctttttcta  tgggtcaca  agacggaat  cactctaat  taattttgt  1080
tgctccatc  ggaggaccc  agtgtgtcg  gatcagtgt  tacatactg  gctaactgg  1140
ttacagctt  tttgtttta  aactttacc  ctctctgaa  agtctgtaa  caaggacgc  1200
ctgaggatg  agctggcag  ctgtcctag  tattctttc  atgcttgca  cctgtcgtc  1260
aatgtgtct  ataaccctt  gtaacacag  tatccccaa  gtgcctaat  aaatctgtc  1320
tttcaagctc  1330



<210> 2755
<211> 330
<212> PRT
<213> Rattus norvegicus
<308> Q02765
<400> 2755

Met Ala Val Leu Gly Ala Pro Gly Val Leu Cys Asp Asn Gly Ala Thr 
  1               5                  10                  15
Ala Glu Arg Pro Thr Leu Asp His His Trp Asp Leu Trp Lys Lys Thr 
             20                  25                  30
Arg Met Arg Arg Asn Thr Asp Gln Asn Glu Glu Asp Val Arg Arg Leu 
         35                  40                  45
Ile Trp Glu Lys Asn Leu Lys Phe Ile Met Leu His Asn Leu Glu His 
     50                  55                  60
Ser Met Gly Met His Ser Tyr Ser Val Gly Met Asn His Met Gly Asp 
 65                  70                  75                  80
Met Thr Pro Glu Glu Val Ile Gly Tyr Met Gly Ser Leu Arg Ile Pro 
                 85                  90                  95
Arg Pro Trp Asn Arg Ser Gly Thr Leu Lys Ser Ser Ser Asn Gln Thr 
             100                105                110
Leu Pro Asp Ser Val Asp Trp Arg Glu Lys Gly Cys Val Thr Asn Val 
         115                120                125
Lys Tyr Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Ser Ala Glu Gly 
     130                135                140
Ala Leu Glu Gly Gln Leu Lys Leu Lys Thr Gly Lys Leu Val Ser Leu 
 145                150                155                160
Ser Ala Gln Asn Leu Val Asp Cys Ser Thr Glu Glu Lys Tyr Gly Asn 
                 165                170                175
Lys Gly Cys Gly Gly Gly Phe Met Thr Glu Ala Phe Gln Tyr Ile Ile 
             180                185                190
Asp Thr Ser Ile Asp Ser Glu Ala Ser Tyr Pro Tyr Lys Ala Met Asp 
         195                200                205
Glu Lys Cys Leu Tyr Asp Pro Lys Asn Arg Ala Ala Thr Cys Ser Arg 
     210                215                220
Tyr Ile Glu Leu Pro Phe Gly Asp Glu Glu Ala Leu Lys Glu Ala Val 
 225                230                235                240
Ala Thr Lys Gly Pro Val Ser Val Gly Ile Asp Asp Ala Ser His Ser 
                 245                250                255
Ser Phe Phe Leu Tyr Gln Ser Gly Val Tyr Asp Asp Pro Ser Cys Thr 
             260                265                270
Glu Asn Met Asn His Gly Val Leu Val Val Gly Tyr Gly Thr Leu Asp 
         275                280                285
Gly Lys Asp Tyr Trp Leu Val Lys Asn Ser Trp Gly Leu His Phe Gly 
     290                295                300
Asp Gln Gly Tyr Ile Arg Met Ala Arg Asn Asn Lys Asn His Cys Gly 
 305                310                315                320
Ile Ala Ser Tyr Cys Ser Tyr Pro Glu Ile 
                 325                330



<210> 2756
<211> 1763
<212> DNA
<213> Homo sapiens
<308> M90696
<400> 2756

ggggtacct  atgtgacaa  ttccaattt  ttttcaagt  aattgaact  aaatctcct  60
gttgctttg  aatcttaga  gagagccca  taattcaag  actcttact  taggagcaa  120
tgctggttc  atcacaatg  aacggctgg  ttgtgtgct  ttggtgtgc  cctctgcag  180
ggcacagtt  cataaagat  ctaccctgg  tcaccactg  catctctgg  agaaaacct  240
tggcaaaca  tacaaggaa  agaatgaag  agcagtacg  cgtctcatc  gggaaaaga  300
tctaaagtt  gtgatgctt  acaacctgg  gcattcaat  ggaatgcac  catacgatc  360
gggcatgaa  cacctggga  acatgacca  tgaagaagt  atgtctttg  tgagttccc  420
gagagttcc  agccagtgg  agagaaata  cacatataa  tcaaaccct  atcggatat  480
gcctgattc  gtggactgg  gagagaaag  gtgtgttac  gaagtgaaa  atcaaggtt  540
ttgtggtgc  tgctgggct  tcagtgctg  gggggccct  gaagcacag  tgaagctga  600
aacaggaaa  ctggtgtct  tcagtgccc  gaacctggt  gattgctca  ctgaaaaat  660
tggaaacaa  ggctgcaat  gtggcttca  gacaacggc  ttccagtac  tcattgata  720
caagggcat  gactcagac  cttcctatc  ctacaaagc  atggatctg  aatgtcaat  780
tgactcaaa  tatcgtgct  ccacatgtt  aaagtacac  gaacttcct  atggcagag  840
agatgtcct  aaagaagct  tggccaata  aggcccagt  tctgttggt  tagatgcgc  900
tcatccttc  ttcttcctc  acagaagtg  tgtctacta  gaaccatcc  gtactcaga  960
tgtgaatca  ggtgtactt  tggttggct  tggtgatct  aatgggaaa  aatactggc  1020
tgtgaaaaa  agctggggc  acaactttg  tgaagaagg  tatattcgg  tggcaagaa  1080
taaaggaaa  cattgtggg  ttgctagct  tccctctta  ccagaaatc  agaggatct  1140
tccttttta  aacaaatca  tgaaatatg  agcactttc  cttaactta  tttttcctg  1200
tgtatccag  agaaataat  gtgtcatga  taatgtgta  ttactgtac  aattagaaa  1260
tatagtttg  ggccgggca  gtggctcac  cgtaatccc  ttacttggg  ggccaaggc  1320
ggcattatc  atcttgagg  caggagtta  agagcagcc  ggctaacat  gtgaaaccc  1380
atctctact  aaaatacaa  aaattagcc  agcacggtg  tgcatgcct  taatcccag  1440
tacttggga  gctgaggca  gagattcct  gaacccaag  ggttgaggc  atgttgagc  1500
gagatcaca  cactgtact  cagcctgga  gacagagtg  agactctgt  tcaaaaaaa  1560
agaaaagaa  atatagttt  attcttcat  tttttaaat  tgcaaatct  aggataaag  1620
ttgctaagt  aattagtaa  gtactatag  tataactgt  caaaaattg  tcaacctaa  1680
acaatctgt  attgcttat  gttttattg  cccgaattc  gttggttta  tatattgtc  1740
tctgtaatt  cgatccttc  taa  1763



<210> 2757
<211> 331
<212> PRT
<213> Homo sapiens
<308> P25774
<400> 2757

Met Lys Arg Leu Val Cys Val Leu Leu Val Cys Ser Ser Ala Val Ala 
  1               5                  10                  15
Gln Leu His Lys Asp Pro Thr Leu Asp His His Trp His Leu Trp Lys 
             20                  25                  30
Lys Thr Tyr Gly Lys Gln Tyr Lys Glu Lys Asn Glu Glu Ala Val Arg 
         35                  40                  45
Arg Leu Ile Trp Glu Lys Asn Leu Lys Phe Val Met Leu His Asn Leu 
     50                  55                  60
Glu His Ser Met Gly Met His Ser Tyr Asp Leu Gly Met Asn His Leu 
 65                  70                  75                  80
Gly Asp Met Thr Ser Glu Glu Val Met Ser Leu Met Ser Ser Leu Arg 
                 85                  90                  95
Val Pro Ser Gln Trp Gln Arg Asn Ile Thr Tyr Lys Ser Asn Pro Asn 
             100                105                110
Arg Ile Leu Pro Asp Ser Val Asp Trp Arg Glu Lys Gly Cys Val Thr 
         115                120                125
Glu Val Lys Tyr Gln Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser Ala 
     130                135                140
Val Gly Ala Leu Glu Ala Gln Leu Lys Leu Lys Thr Gly Lys Leu Val 
 145                150                155                160
Thr Leu Ser Ala Gln Asn Leu Val Asp Cys Ser Thr Glu Lys Tyr Gly 
                 165                170                175
Asn Lys Gly Cys Asn Gly Gly Phe Met Thr Thr Ala Phe Gln Tyr Ile 
             180                185                190
Ile Asp Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys Ala 
         195                200                205
Met Asp Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Thr Cys 
     210                215                220
Ser Lys Tyr Thr Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys Glu 
 225                230                235                240
Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg His 
                 245                250                255
Pro Ser Phe Phe Leu Tyr Arg Ser Gly Val Tyr Tyr Glu Pro Ser Cys 
             260                265                270
Thr Gln Asn Val Asn His Gly Val Leu Val Val Gly Tyr Gly Asp Leu 
         275                280                285
Asn Gly Lys Glu Tyr Trp Leu Val Lys Asn Ser Trp Gly His Asn Phe 
     290                295                300
Gly Glu Glu Gly Tyr Ile Arg Met Ala Arg Asn Lys Gly Asn His Cys 
 305                310                315                320
Gly Ile Ala Ser Phe Pro Ser Tyr Pro Glu Ile 
                 325                330



<210> 2758
<211> 3617
<212> DNA
<213> Rattus norvegicus
<308> L03294
<400> 2758

ttctgcccc  tgtagctgt  ctgccctcc  ctttaaagg  tgacttgcc  cgcggcgct  60
caccgcgct  tagtcctct  acgcctccg  ctcaaccct  tgcaacgcg  atccccgcc  120
gcctgactg  ccgcgcagc  cagttccag  agcaaagca  aagggcgcg  cgagatgga  180
agcaaagcc  tgctcctgg  ggccctggg  gtttggctc  agagtttga  cgccttccg  240
ggaggggtg  ccgcagcag  cgggggaag  gatttctca  acatcgaaa  taaatttgc  300
ctaaggacc  ctgaagaca  agctgagga  acttgtcat  tgattcctg  attagcaga  360
tctgtgtct  actgccact  caaccacag  agcaaaacc  ttgtggtga  ccatggatg  420
acggtgaca  gaatgtatg  gagttgggt  cccaaactt  tggctgccc  atacaaaag  480
gaacctgac  ccaatgtca  tgtagtaga  tggttgtat  gggcccagc  acattatcc  540
gtgtctgcc  gctatacca  gctggtggg  aatgatgtg  ccaggttca  caactggct  600
gaggaagaa  ttaactacc  cctagacaa  gtccacctc  tagggtaca  tcttggagc  660
catgctgct  gcgtggcag  aagtctgac  aacaagaag  tcaatagaa  tactggctt  720
gatccagct  ggcctaact  tgagtatgc  gaagcccct  gtcgccttt  tcctgatga  780
gcggatttc  tagatgtct  acacacatt  accaggggg  cgcctggtc  aagtattgg  840
atccagaaa  cagtagggc  tgttgatat  tatcccaat  gaggcactt  ccagccagg  900
tgcaacatt  gagaagcca  tcgtgtaat  gcagagaag  ggcttggag  tgtggacca  960
ctggtgaag  gctcgcacg  gcgctccat  catctcttc  ttgactccc  gctgaatga  1020
gaaaacccc  gcaaggcat  caggtgcaa  tccaaggag  cctttgaga  agggctctg  1080
ctgagttgc  gaaagaatc  ctgtaacaa  gtgggctat  agatcaaca  ggtcagagc  1140
aagagaagc  gtaagatgt  cctgaagac  cgctctcag  tgccctaca  agtattcca  1200
taccaagtc  agattcact  ttctggaac  gagaatgac  agcaaaaca  ccaggcctt  1260
gagatttct  tgtatggca  agtggctga  agtgagaac  ttcccttca  cctgccgga  1320
gtcgccaca  ataaaacct  ctccttctt  atttacacg  aggtggaca  cggggaatt  1380
ctgatgatg  agcttaagt  gaagaacga  tcctacttc  gctggtcag  ctggtggag  1440
agtcccagc  ttgtcatcg  gaagatccg  gtgaaagcc  gagagactc  gaaaaaggt  1500
atcttctgt  ccagggaga  agtttctca  ctgcagaaa  gaaaggacg  tgcagtgtt  1560
gtgaaatgc  atgacaagt  tctgaagaa  tcgggctga  actggacaa  ccaacaaga  1620
aagaaagca  ctgagttct  tgaagaccg  agaaaatga  gtaaatttt  tttaaaaaa  1680
atacccttg  ttgggtgtt  gaaagtgga  tttcctgag  attaatccc  gctatatct  1740
gttagttaa  tagaagaca  tgtcaaata  taaaaggtg  ctaacacaa  gtgaggaac  1800
taatggccg  tagcatgtc  tccagcatc  gaagacagc  gagaggaga  gcatgccat  1860
ttatatccc  taagaagga  tcatttgtt  ccaaccata  aagactcct  catgtgacc  1920
atttggtca  ggtctaaaa  tagtaaggg  ctcttattt  cattagatc  ctgaggttt  1980
aaattgaga  cttctcaaa  ttctcttga  gtctaatat  gacaacatt  ttttgtgct  2040
tgagtcaga  ccatttctt  agcagttga  acagctggc  attgtaact  gttctttta  2100
catcaggat  tagcacccc  accaaataa  ataaataaa  aaagtgacc  gggacatgt  2160
actttgcaa  agcaatgga  gacgtggct  gtggattcc  gacccttag  cccaccaca  2220
cgaagtaca  gtcagtaga  gtacaaaac  tagactgag  aattcttag  agacttcaa  2280
ttttatggc  taattcctc  gtcttttaa  aacgtgtca  atattataa  attattctc  2340
agacagatg  tgaaatgag  ttgtgattc  ggtgacata  gaattgagc  gagagaaaa  2400
aatgccctg  ctgatttta  ttctctgtt  tgctttctt  agaaaagga  tacttgtcc  2460
actccgtat  tgagcctga  caagaacta  actatgtac  tcaggctta  cttgaactc  2520
caaccatcc  gccttggct  cctgagtgc  gggagcttg  taaccataa  tttattatc  2580
gatttttct  agtcatttt  accaataga  cacattcaa  gcccaatcg  tagcatttc  2640
tttgagact  atcttgacc  tacctctgt  acacgtcta  cacatcaca  taatttcta  2700
tttagaagt  atcaagttc  aattctgca  tgcgcaaag  acaagtttt  gagcaggac  2760
atttttttt  taccacgta  aagtcgaaa  tactaggaa  tgtgtatat  gatgcttgt  2820
cactgttgc  tgcaaagtg  ggagccttc  attgtgata  ccatagaca  taccaggct  2880
gttgccgct  ttttgtttt  ctataaaaa  ataatgaag  attatttat  aacaagatc  2940
catatgttc  gattgcttt  actattcat  aatataaaa  gttaaaaaa  aaaaataaa  3000
caagttcta  ctcagaggc  gttgctggg  acagaaact  tgaaatgtg  gggtatctg  3060
acacctaca  acaagcaaa  ccccacaag  gtctttgtc  ttcaatgtc  ttcagaaag  3120
aaagagtca  gagatatac  ataatatgt  agagaagta  ttccagata  gctggaatg  3180
tagcccttg  taggagaaa  ttggttgtg  ctatgtaat  taggacaaa  gtgactggt  3240
tcattaggc  cagtgtcat  ctaacaata  aatgatgta  catatgtca  cagcatccc  3300
attattgct  attcatggc  gtatatacg  acatatctc  atgatgctt  gactttaaa  3360
tttatttat  agctgtaaa  aatgtgtgg  tgtgtaagg  agcttgtaa  cactggaaa  3420
gctgttgtg  ctatctggg  tgtagattt  tggtgctaa  tctgtgtcc  cctccatca  3480
tgattgtct  actgagcca  ctcactctg  tgaacagca  aatggaata  cttttgaag  3540
aagaaaata  actcacctg  gtgaagaaa  gggatctgc  ttcaataaa  tcgagaacg  3600
tttatccgg  atccgcg  3617



<210> 2759
<211> 474
<212> PRT
<213> Rattus norvegicus
<308> Q06000
<400> 2759

Met Glu Ser Lys Ala Leu Leu Leu Val Ala Leu Gly Val Trp Leu Gln 
  1               5                  10                  15
Ser Leu Thr Ala Phe Arg Gly Gly Val Ala Ala Ala Asp Gly Gly Arg 
             20                  25                  30
Asp Phe Ser Asp Ile Glu Ser Lys Phe Ala Leu Arg Thr Pro Glu Asp 
         35                  40                  45
Thr Ala Glu Asp Thr Cys His Leu Ile Pro Gly Leu Ala Asp Ser Val 
     50                  55                  60
Ser Asn Cys His Phe Asn His Ser Ser Lys Thr Phe Val Val Ile His 
 65                  70                  75                  80
Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp Val Pro Lys Leu Val 
                 85                  90                  95
Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser Asn Val Ile Val Val Asp 
             100                105                110
Trp Leu Tyr Arg Ala Gln Gln His Tyr Pro Val Ser Ala Gly Tyr Thr 
         115                120                125
Lys Leu Val Gly Asn Asp Val Ala Arg Phe Ile Asn Trp Leu Glu Glu 
     130                135                140
Glu Phe Asn Tyr Pro Leu Asp Asn Val His Leu Leu Gly Tyr Ser Leu 
 145                150                155                160
Gly Ala His Ala Ala Gly Val Ala Gly Ser Leu Thr Asn Lys Lys Val 
                 165                170                175
Asn Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro Asn Phe Glu Tyr Ala 
             180                185                190
Glu Ala Pro Ser Arg Leu Ser Pro Asp Asp Ala Asp Phe Val Asp Val 
         195                200                205
Leu His Thr Phe Thr Arg Gly Ser Pro Gly Arg Ser Ile Gly Ile Gln 
     210                215                220
Lys Pro Val Gly His Val Asp Ile Tyr Pro Asn Gly Gly Thr Phe Gln 
 225                230                235                240
Pro Gly Cys Asn Ile Gly Glu Ala Ile Arg Val Ile Ala Glu Lys Gly 
                 245                250                255
Leu Gly Asp Val Asp Gln Leu Val Lys Cys Ser His Glu Arg Ser Ile 
             260                265                270
His Leu Phe Ile Asp Ser Leu Leu Asn Glu Glu Asn Pro Ser Lys Ala 
         275                280                285
Tyr Arg Cys Asn Ser Lys Glu Ala Phe Glu Lys Gly Leu Cys Leu Ser 
     290                295                300
Cys Arg Lys Asn Arg Cys Asn Asn Val Gly Tyr Glu Ile Asn Lys Val 
 305                310                315                320
Arg Ala Lys Arg Ser Ser Lys Met Tyr Leu Lys Thr Arg Ser Gln Met 
                 325                330                335
Pro Tyr Lys Val Phe His Tyr Gln Val Lys Ile His Phe Ser Gly Thr 
             340                345                350
Glu Asn Asp Lys Gln Asn Asn Gln Ala Phe Glu Ile Ser Leu Tyr Gly 
         355                360                365
Thr Val Ala Glu Ser Glu Asn Ile Pro Phe Thr Leu Pro Glu Val Ala 
     370                375                380
Thr Asn Lys Thr Tyr Ser Phe Leu Ile Tyr Thr Glu Val Asp Ile Gly 
 385                390                395                400
Glu Leu Leu Met Met Lys Leu Lys Trp Lys Asn Asp Ser Tyr Phe Arg 
                 405                410                415
Trp Ser Asp Trp Trp Ser Ser Pro Ser Phe Val Ile Glu Lys Ile Arg 
             420                425                430
Val Lys Ala Gly Glu Thr Gln Lys Lys Val Ile Phe Cys Ala Arg Glu 
         435                440                445
Lys Val Ser His Leu Gln Lys Gly Lys Asp Ala Ala Val Phe Val Lys 
     450                455                460
Cys His Asp Lys Ser Leu Lys Lys Ser Gly 
 465                470



<210> 2760
<211> 3549
<212> DNA
<213> Homo sapiens
<308> M15856
<400> 2760

cccctcttc  tcctcctca  gggaaagct  cccacttct  gctgccctg  catcccctt  60
aaagggcga  ttgctcagc  ccaaaccgc  gctccagcc  tctccagcc  ccggctcag  120
cggctcatc  gtcggtccg  gccttgcag  tcctccaga  ggacgcgcc  cgagatgga  180
agcaaagcc  tgctcgtgc  gactctggc  gtgtggctc  agagtctga  cgcctcccg  240
ggaggggtg  ccgccgccg  ccaaagaag  gattttatc  acatcgaaa  taaatttgc  300
ctaaggacc  ctgaagaca  agctgagga  acttgccac  tcattcccg  agtagcaga  360
tccgtggct  cctgtcatt  caatcacag  agcaaaacc  tcatggtga  ccatggctg  420
acggtaaca  gaatgtatg  gagttgggt  ccaaaactt  tggccgccc  gtacaagag  480
gaaccagac  ccaatgtca  tgtggtgga  tggctgtca  gggctcagg  gcattaccc  540
gtgtccgcg  gctacacca  actggtggg  caggatgtg  cccggttta  caactggat  600
gaggaggag  ttaactacc  tctggacaa  gtccatctc  tgggataca  ccttggagc  660
catgctgct  gcattgcag  aagtctgac  aataagaaa  tcaacagaa  tactggcct  720
gatccagct  gacctaact  tgagtatgc  gaagccccg  gtcgtcttt  tcctgatga  780
gcagatttt  tagacgtct  acacacatt  accagaggg  cccctggtc  aagcattgg  840
atccagaaa  cagttgggc  tgttgacat  tacccgaat  gaggtactt  tcagccagg  900
tgtaacatt  gagaagcta  ccgcgtgat  gcagagaga  gacttggag  tgtggacca  960
ctagtgaag  gctcccacg  gcgctccat  catctcttc  tcgactctc  gttgaatga  1020
gaaaatcca  gtaaggcct  caggtgcag  tccaaggaa  cctttgaga  agggctctg  1080
ttgagttgt  gaaagaacc  ctgcaacaa  ctgggctat  agatcaata  agtcagagc  1140
aaaagaagc  gcaaaatgt  cctgaagac  cgttctcag  tgccctaca  agtcttcca  1200
taccaagta  agattcatt  ttctgggac  gagagtgaa  cccatacca  tcaggcctt  1260
gagatttct  tgtatggca  cgtggccga  agtgagaac  tcccattca  tctgcctga  1320
gtttccaca  ataagacct  ctccttcct  atttacaca  aggtagata  tggagaact  1380
ctcatgttg  agctcaaat  gaagagtga  tcatacttt  gctggtcag  ctggtggag  1440
agtcccggc  tcgccattc  gaagatcag  gtaaaagca  gagagactc  gaaaaaggt  1500
atcttctgt  ctagggaga  agtgtctca  ttgcagaaa  gaaaggcac  tgcggtatt  1560
gtgaaatgc  atgacaagt  tctgaataa  aagtcaggc  gaaactggg  gaatctaca  1620
aacaaagaa  ggcatgtga  ttctgtgaa  aatgaagtg  aggaagtaa  ttttacaaa  1680
catacccag  gtttggggt  tttcaaaag  ggattttcc  gaatattaa  cccagccct  1740
cccttgtta  ttattttag  agacagtct  aagcactaa  aagtggcta  ttcaattta  1800
ggggtatag  ggccaaata  cacatcctc  aacgttaaa  gacagtgga  catgaaaag  1860
gctgttttg  cctttgaga  agaaataat  gtttgagcg  agagtaaaa  aaggctcct  1920
catgtggcg  attgggcca  agcctataa  tggttagaa  ctcctattt  aattggaat  1980
ctggatctt  cggactgag  ccttctcaa  ctttactct  agtctccaa  aatacagaa  2040
atgcttttc  gcggcacga  tcagactca  ctacacagc  gtatgaatg  tgttttaga  2100
tgattccct  ttgctattg  aatgtggtc  agacgtcaa  caggaacat  taacttgga  2160
agggacgaa  aaagggtct  ataaacaca  aggttttaa  cagtcccta  cattggcct  2220
catcatgac  aagttacaa  ttcaaggag  tataaaatc  agatcaatt  attcttaat  2280
ggctttatc  tttattgct  aatccctct  tcccccttc  tttttgtct  aagattata  2340
tataataat  ttctctggg  aggtgttga  aatgagcct  taatcctca  ctgacacat  2400
atttgaatg  tgcagaaaa  aaaaagata  cgtaatttt  ttattagat  ctccaaatg  2460
ttttcatca  tttaaaatc  ttcaatatc  gacagttac  cttcagttt  aggcttacc  2520
tggtcatgc  tcagttgta  ttccagtgc  tctcttttg  tcctggctt  gacatgaaa  2580
gataggttt  agttcaaat  ttgcattgt  tgagcttct  cagatttta  acaaggacc  2640
tttttacta  gtaaaaggg  ggagaggtt  ctggggtgg  ttcctaagc  gtgcttgta  2700
accatcgcg  gcaatgagc  agatggagt  ccatgaggg  tgttatttg  tgtttttaa  2760
aactaatca  gagtgagtg  acaactatt  ataaactag  tctcctatt  ttcagaatg  2820
tcttctacg  ataaatatg  aatgataaa  atgtcaaat  tctcagagg  tatagctgg  2880
aacccgact  tgaaagtat  tgatatctg  acacatact  gaaagctct  catgtgtgt  2940
gtccttcag  ataattcgg  agggaaaac  gtcgatcaa  ggatgtatt  gaacatgtc  3000
gagtagaaa  tgttcctga  gtgccagaa  ttcgaccct  tctctgaga  agatgatcg  3060
gcctataaa  agtaggacc  atgttgtga  taacatcat  aggcttgga  tgaattctc  3120
ctaaaaata  aatgatgta  gatttgttg  tggcatccc  tttattaat  cattaaatt  3180
ctggatttg  gttgtgacc  agggtgcat  aacttaaaa  attcactaa  gcagcacat  3240
gcactggga  ctctggctc  gaaaaactt  gttatatat  tcaaggatg  tctggcttt  3300
cattttatt  attagctgt  aatacatgt  tggatgtgt  aatggagct  gtacatatt  3360
gaaaggtca  tgtggctat  tgcatttat  aatgtgtgg  gctaactgt  tgtgtcttt  3420
tcagtgatg  tctcacaga  ccaactcac  cttatgaaa  gggctttaa  aaaacaaga  3480
agaaacgta  ttaactgtg  gaagaaatg  aatcagctt  taataaaat  gacaacatt  3540
tattaccac  3549



<210> 2761
<211> 475
<212> PRT
<213> Homo sapiens
<308> P06858
<400> 2761

Met Glu Ser Lys Ala Leu Leu Val Leu Thr Leu Ala Val Trp Leu Gln 
  1               5                  10                  15
Ser Leu Thr Ala Ser Arg Gly Gly Val Ala Ala Ala Asp Gln Arg Arg 
             20                  25                  30
Asp Phe Ile Asp Ile Glu Ser Lys Phe Ala Leu Arg Thr Pro Glu Asp 
         35                  40                  45
Thr Ala Glu Asp Thr Cys His Leu Ile Pro Gly Val Ala Glu Ser Val 
     50                  55                  60
Ala Thr Cys His Phe Asn His Ser Ser Lys Thr Phe Met Val Ile His 
 65                  70                  75                  80
Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp Val Pro Lys Leu Val 
                 85                  90                  95
Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser Asn Val Ile Val Val Asp 
             100                105                110
Trp Leu Ser Arg Ala Gln Glu His Tyr Pro Val Ser Ala Gly Tyr Thr 
         115                120                125
Lys Leu Val Gly Gln Asp Val Ala Arg Phe Ile Asn Trp Met Glu Glu 
     130                135                140
Glu Phe Asn Tyr Pro Leu Asp Asn Val His Leu Leu Gly Tyr Ser Leu 
 145                150                155                160
Gly Ala His Ala Ala Gly Ile Ala Gly Ser Leu Thr Asn Lys Lys Val 
                 165                170                175
Asn Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro Asn Phe Glu Tyr Ala 
             180                185                190
Glu Ala Pro Ser Arg Leu Ser Pro Asp Asp Ala Asp Phe Val Asp Val 
         195                200                205
Leu His Thr Phe Thr Arg Gly Ser Pro Gly Arg Ser Ile Gly Ile Gln 
     210                215                220
Lys Pro Val Gly His Val Asp Ile Tyr Pro Asn Gly Gly Thr Phe Gln 
 225                230                235                240
Pro Gly Cys Asn Ile Gly Glu Ala Ile Arg Val Ile Ala Glu Arg Gly 
                 245                250                255
Leu Gly Asp Val Asp Gln Leu Val Lys Cys Ser His Glu Arg Ser Ile 
             260                265                270
His Leu Phe Ile Asp Ser Leu Leu Asn Glu Glu Asn Pro Ser Lys Ala 
         275                280                285
Tyr Arg Cys Ser Ser Lys Glu Ala Phe Glu Lys Gly Leu Cys Leu Ser 
     290                295                300
Cys Arg Lys Asn Arg Cys Asn Asn Leu Gly Tyr Glu Ile Asn Lys Val 
 305                310                315                320
Arg Ala Lys Arg Ser Ser Lys Met Tyr Leu Lys Thr Arg Ser Gln Met 
                 325                330                335
Pro Tyr Lys Val Phe His Tyr Gln Val Lys Ile His Phe Ser Gly Thr 
             340                345                350
Glu Ser Glu Thr His Thr Asn Gln Ala Phe Glu Ile Ser Leu Tyr Gly 
         355                360                365
Thr Val Ala Glu Ser Glu Asn Ile Pro Phe Thr Leu Pro Glu Val Ser 
     370                375                380
Thr Asn Lys Thr Tyr Ser Phe Leu Ile Tyr Thr Glu Val Asp Ile Gly 
 385                390                395                400
Glu Leu Leu Met Leu Lys Leu Lys Trp Lys Ser Asp Ser Tyr Phe Ser 
                 405                410                415
Trp Ser Asp Trp Trp Ser Ser Pro Gly Phe Ala Ile Gln Lys Ile Arg 
             420                425                430
Val Lys Ala Gly Glu Thr Gln Lys Lys Val Ile Phe Cys Ser Arg Glu 
         435                440                445
Lys Val Ser His Leu Gln Lys Gly Lys Ala Pro Ala Val Phe Val Lys 
     450                455                460
Cys His Asp Lys Ser Leu Asn Lys Lys Ser Gly 
 465                470                475



<210> 2762
<211> 3617
<212> DNA
<213> Rattus norvegicus
<308> L03294
<400> 2762

ttctgcccc  tgtagctgt  ctgccctcc  ctttaaagg  tgacttgcc  cgcggcgct  60
caccgcgct  tagtcctct  acgcctccg  ctcaaccct  tgcaacgcg  atccccgcc  120
gcctgactg  ccgcgcagc  cagttccag  agcaaagca  aagggcgcg  cgagatgga  180
agcaaagcc  tgctcctgg  ggccctggg  gtttggctc  agagtttga  cgccttccg  240
ggaggggtg  ccgcagcag  cgggggaag  gatttctca  acatcgaaa  taaatttgc  300
ctaaggacc  ctgaagaca  agctgagga  acttgtcat  tgattcctg  attagcaga  360
tctgtgtct  actgccact  caaccacag  agcaaaacc  ttgtggtga  ccatggatg  420
acggtgaca  gaatgtatg  gagttgggt  cccaaactt  tggctgccc  atacaaaag  480
gaacctgac  ccaatgtca  tgtagtaga  tggttgtat  gggcccagc  acattatcc  540
gtgtctgcc  gctatacca  gctggtggg  aatgatgtg  ccaggttca  caactggct  600
gaggaagaa  ttaactacc  cctagacaa  gtccacctc  tagggtaca  tcttggagc  660
catgctgct  gcgtggcag  aagtctgac  aacaagaag  tcaatagaa  tactggctt  720
gatccagct  ggcctaact  tgagtatgc  gaagcccct  gtcgccttt  tcctgatga  780
gcggatttc  tagatgtct  acacacatt  accaggggg  cgcctggtc  aagtattgg  840
atccagaaa  cagtagggc  tgttgatat  tatcccaat  gaggcactt  ccagccagg  900
tgcaacatt  gagaagcca  tcgtgtaat  gcagagaag  ggcttggag  tgtggacca  960
ctggtgaag  gctcgcacg  gcgctccat  catctcttc  ttgactccc  gctgaatga  1020
gaaaacccc  gcaaggcat  caggtgcaa  tccaaggag  cctttgaga  agggctctg  1080
ctgagttgc  gaaagaatc  ctgtaacaa  gtgggctat  agatcaaca  ggtcagagc  1140
aagagaagc  gtaagatgt  cctgaagac  cgctctcag  tgccctaca  agtattcca  1200
taccaagtc  agattcact  ttctggaac  gagaatgac  agcaaaaca  ccaggcctt  1260
gagatttct  tgtatggca  agtggctga  agtgagaac  ttcccttca  cctgccgga  1320
gtcgccaca  ataaaacct  ctccttctt  atttacacg  aggtggaca  cggggaatt  1380
ctgatgatg  agcttaagt  gaagaacga  tcctacttc  gctggtcag  ctggtggag  1440
agtcccagc  ttgtcatcg  gaagatccg  gtgaaagcc  gagagactc  gaaaaaggt  1500
atcttctgt  ccagggaga  agtttctca  ctgcagaaa  gaaaggacg  tgcagtgtt  1560
gtgaaatgc  atgacaagt  tctgaagaa  tcgggctga  actggacaa  ccaacaaga  1620
aagaaagca  ctgagttct  tgaagaccg  agaaaatga  gtaaatttt  tttaaaaaa  1680
atacccttg  ttgggtgtt  gaaagtgga  tttcctgag  attaatccc  gctatatct  1740
gttagttaa  tagaagaca  tgtcaaata  taaaaggtg  ctaacacaa  gtgaggaac  1800
taatggccg  tagcatgtc  tccagcatc  gaagacagc  gagaggaga  gcatgccat  1860
ttatatccc  taagaagga  tcatttgtt  ccaaccata  aagactcct  catgtgacc  1920
atttggtca  ggtctaaaa  tagtaaggg  ctcttattt  cattagatc  ctgaggttt  1980
aaattgaga  cttctcaaa  ttctcttga  gtctaatat  gacaacatt  ttttgtgct  2040
tgagtcaga  ccatttctt  agcagttga  acagctggc  attgtaact  gttctttta  2100
catcaggat  tagcacccc  accaaataa  ataaataaa  aaagtgacc  gggacatgt  2160
actttgcaa  agcaatgga  gacgtggct  gtggattcc  gacccttag  cccaccaca  2220
cgaagtaca  gtcagtaga  gtacaaaac  tagactgag  aattcttag  agacttcaa  2280
ttttatggc  taattcctc  gtcttttaa  aacgtgtca  atattataa  attattctc  2340
agacagatg  tgaaatgag  ttgtgattc  ggtgacata  gaattgagc  gagagaaaa  2400
aatgccctg  ctgatttta  ttctctgtt  tgctttctt  agaaaagga  tacttgtcc  2460
actccgtat  tgagcctga  caagaacta  actatgtac  tcaggctta  cttgaactc  2520
caaccatcc  gccttggct  cctgagtgc  gggagcttg  taaccataa  tttattatc  2580
gatttttct  agtcatttt  accaataga  cacattcaa  gcccaatcg  tagcatttc  2640
tttgagact  atcttgacc  tacctctgt  acacgtcta  cacatcaca  taatttcta  2700
tttagaagt  atcaagttc  aattctgca  tgcgcaaag  acaagtttt  gagcaggac  2760
atttttttt  taccacgta  aagtcgaaa  tactaggaa  tgtgtatat  gatgcttgt  2820
cactgttgc  tgcaaagtg  ggagccttc  attgtgata  ccatagaca  taccaggct  2880
gttgccgct  ttttgtttt  ctataaaaa  ataatgaag  attatttat  aacaagatc  2940
catatgttc  gattgcttt  actattcat  aatataaaa  gttaaaaaa  aaaaataaa  3000
caagttcta  ctcagaggc  gttgctggg  acagaaact  tgaaatgtg  gggtatctg  3060
acacctaca  acaagcaaa  ccccacaag  gtctttgtc  ttcaatgtc  ttcagaaag  3120
aaagagtca  gagatatac  ataatatgt  agagaagta  ttccagata  gctggaatg  3180
tagcccttg  taggagaaa  ttggttgtg  ctatgtaat  taggacaaa  gtgactggt  3240
tcattaggc  cagtgtcat  ctaacaata  aatgatgta  catatgtca  cagcatccc  3300
attattgct  attcatggc  gtatatacg  acatatctc  atgatgctt  gactttaaa  3360
tttatttat  agctgtaaa  aatgtgtgg  tgtgtaagg  agcttgtaa  cactggaaa  3420
gctgttgtg  ctatctggg  tgtagattt  tggtgctaa  tctgtgtcc  cctccatca  3480
tgattgtct  actgagcca  ctcactctg  tgaacagca  aatggaata  cttttgaag  3540
aagaaaata  actcacctg  gtgaagaaa  gggatctgc  ttcaataaa  tcgagaacg  3600
tttatccgg  atccgcg  3617



<210> 2763
<211> 474
<212> PRT
<213> Rattus norvegicus
<308> Q06000
<400> 2763

Met Glu Ser Lys Ala Leu Leu Leu Val Ala Leu Gly Val Trp Leu Gln 
  1               5                  10                  15
Ser Leu Thr Ala Phe Arg Gly Gly Val Ala Ala Ala Asp Gly Gly Arg 
             20                  25                  30
Asp Phe Ser Asp Ile Glu Ser Lys Phe Ala Leu Arg Thr Pro Glu Asp 
         35                  40                  45
Thr Ala Glu Asp Thr Cys His Leu Ile Pro Gly Leu Ala Asp Ser Val 
     50                  55                  60
Ser Asn Cys His Phe Asn His Ser Ser Lys Thr Phe Val Val Ile His 
 65                  70                  75                  80
Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp Val Pro Lys Leu Val 
                 85                  90                  95
Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser Asn Val Ile Val Val Asp 
             100                105                110
Trp Leu Tyr Arg Ala Gln Gln His Tyr Pro Val Ser Ala Gly Tyr Thr 
         115                120                125
Lys Leu Val Gly Asn Asp Val Ala Arg Phe Ile Asn Trp Leu Glu Glu 
     130                135                140
Glu Phe Asn Tyr Pro Leu Asp Asn Val His Leu Leu Gly Tyr Ser Leu 
 145                150                155                160
Gly Ala His Ala Ala Gly Val Ala Gly Ser Leu Thr Asn Lys Lys Val 
                 165                170                175
Asn Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro Asn Phe Glu Tyr Ala 
             180                185                190
Glu Ala Pro Ser Arg Leu Ser Pro Asp Asp Ala Asp Phe Val Asp Val 
         195                200                205
Leu His Thr Phe Thr Arg Gly Ser Pro Gly Arg Ser Ile Gly Ile Gln 
     210                215                220
Lys Pro Val Gly His Val Asp Ile Tyr Pro Asn Gly Gly Thr Phe Gln 
 225                230                235                240
Pro Gly Cys Asn Ile Gly Glu Ala Ile Arg Val Ile Ala Glu Lys Gly 
                 245                250                255
Leu Gly Asp Val Asp Gln Leu Val Lys Cys Ser His Glu Arg Ser Ile 
             260                265                270
His Leu Phe Ile Asp Ser Leu Leu Asn Glu Glu Asn Pro Ser Lys Ala 
         275                280                285
Tyr Arg Cys Asn Ser Lys Glu Ala Phe Glu Lys Gly Leu Cys Leu Ser 
     290                295                300
Cys Arg Lys Asn Arg Cys Asn Asn Val Gly Tyr Glu Ile Asn Lys Val 
 305                310                315                320
Arg Ala Lys Arg Ser Ser Lys Met Tyr Leu Lys Thr Arg Ser Gln Met 
                 325                330                335
Pro Tyr Lys Val Phe His Tyr Gln Val Lys Ile His Phe Ser Gly Thr 
             340                345                350
Glu Asn Asp Lys Gln Asn Asn Gln Ala Phe Glu Ile Ser Leu Tyr Gly 
         355                360                365
Thr Val Ala Glu Ser Glu Asn Ile Pro Phe Thr Leu Pro Glu Val Ala 
     370                375                380
Thr Asn Lys Thr Tyr Ser Phe Leu Ile Tyr Thr Glu Val Asp Ile Gly 
 385                390                395                400
Glu Leu Leu Met Met Lys Leu Lys Trp Lys Asn Asp Ser Tyr Phe Arg 
                 405                410                415
Trp Ser Asp Trp Trp Ser Ser Pro Ser Phe Val Ile Glu Lys Ile Arg 
             420                425                430
Val Lys Ala Gly Glu Thr Gln Lys Lys Val Ile Phe Cys Ala Arg Glu 
         435                440                445
Lys Val Ser His Leu Gln Lys Gly Lys Asp Ala Ala Val Phe Val Lys 
     450                455                460
Cys His Asp Lys Ser Leu Lys Lys Ser Gly 
 465                470



<210> 2764
<211> 3549
<212> DNA
<213> Homo sapiens
<308> M15856
<400> 2764

cccctcttc  tcctcctca  gggaaagct  cccacttct  gctgccctg  catcccctt  60
aaagggcga  ttgctcagc  ccaaaccgc  gctccagcc  tctccagcc  ccggctcag  120
cggctcatc  gtcggtccg  gccttgcag  tcctccaga  ggacgcgcc  cgagatgga  180
agcaaagcc  tgctcgtgc  gactctggc  gtgtggctc  agagtctga  cgcctcccg  240
ggaggggtg  ccgccgccg  ccaaagaag  gattttatc  acatcgaaa  taaatttgc  300
ctaaggacc  ctgaagaca  agctgagga  acttgccac  tcattcccg  agtagcaga  360
tccgtggct  cctgtcatt  caatcacag  agcaaaacc  tcatggtga  ccatggctg  420
acggtaaca  gaatgtatg  gagttgggt  ccaaaactt  tggccgccc  gtacaagag  480
gaaccagac  ccaatgtca  tgtggtgga  tggctgtca  gggctcagg  gcattaccc  540
gtgtccgcg  gctacacca  actggtggg  caggatgtg  cccggttta  caactggat  600
gaggaggag  ttaactacc  tctggacaa  gtccatctc  tgggataca  ccttggagc  660
catgctgct  gcattgcag  aagtctgac  aataagaaa  tcaacagaa  tactggcct  720
gatccagct  gacctaact  tgagtatgc  gaagccccg  gtcgtcttt  tcctgatga  780
gcagatttt  tagacgtct  acacacatt  accagaggg  cccctggtc  aagcattgg  840
atccagaaa  cagttgggc  tgttgacat  tacccgaat  gaggtactt  tcagccagg  900
tgtaacatt  gagaagcta  ccgcgtgat  gcagagaga  gacttggag  tgtggacca  960
ctagtgaag  gctcccacg  gcgctccat  catctcttc  tcgactctc  gttgaatga  1020
gaaaatcca  gtaaggcct  caggtgcag  tccaaggaa  cctttgaga  agggctctg  1080
ttgagttgt  gaaagaacc  ctgcaacaa  ctgggctat  agatcaata  agtcagagc  1140
aaaagaagc  gcaaaatgt  cctgaagac  cgttctcag  tgccctaca  agtcttcca  1200
taccaagta  agattcatt  ttctgggac  gagagtgaa  cccatacca  tcaggcctt  1260
gagatttct  tgtatggca  cgtggccga  agtgagaac  tcccattca  tctgcctga  1320
gtttccaca  ataagacct  ctccttcct  atttacaca  aggtagata  tggagaact  1380
ctcatgttg  agctcaaat  gaagagtga  tcatacttt  gctggtcag  ctggtggag  1440
agtcccggc  tcgccattc  gaagatcag  gtaaaagca  gagagactc  gaaaaaggt  1500
atcttctgt  ctagggaga  agtgtctca  ttgcagaaa  gaaaggcac  tgcggtatt  1560
gtgaaatgc  atgacaagt  tctgaataa  aagtcaggc  gaaactggg  gaatctaca  1620
aacaaagaa  ggcatgtga  ttctgtgaa  aatgaagtg  aggaagtaa  ttttacaaa  1680
catacccag  gtttggggt  tttcaaaag  ggattttcc  gaatattaa  cccagccct  1740
cccttgtta  ttattttag  agacagtct  aagcactaa  aagtggcta  ttcaattta  1800
ggggtatag  ggccaaata  cacatcctc  aacgttaaa  gacagtgga  catgaaaag  1860
gctgttttg  cctttgaga  agaaataat  gtttgagcg  agagtaaaa  aaggctcct  1920
catgtggcg  attgggcca  agcctataa  tggttagaa  ctcctattt  aattggaat  1980
ctggatctt  cggactgag  ccttctcaa  ctttactct  agtctccaa  aatacagaa  2040
atgcttttc  gcggcacga  tcagactca  ctacacagc  gtatgaatg  tgttttaga  2100
tgattccct  ttgctattg  aatgtggtc  agacgtcaa  caggaacat  taacttgga  2160
agggacgaa  aaagggtct  ataaacaca  aggttttaa  cagtcccta  cattggcct  2220
catcatgac  aagttacaa  ttcaaggag  tataaaatc  agatcaatt  attcttaat  2280
ggctttatc  tttattgct  aatccctct  tcccccttc  tttttgtct  aagattata  2340
tataataat  ttctctggg  aggtgttga  aatgagcct  taatcctca  ctgacacat  2400
atttgaatg  tgcagaaaa  aaaaagata  cgtaatttt  ttattagat  ctccaaatg  2460
ttttcatca  tttaaaatc  ttcaatatc  gacagttac  cttcagttt  aggcttacc  2520
tggtcatgc  tcagttgta  ttccagtgc  tctcttttg  tcctggctt  gacatgaaa  2580
gataggttt  agttcaaat  ttgcattgt  tgagcttct  cagatttta  acaaggacc  2640
tttttacta  gtaaaaggg  ggagaggtt  ctggggtgg  ttcctaagc  gtgcttgta  2700
accatcgcg  gcaatgagc  agatggagt  ccatgaggg  tgttatttg  tgtttttaa  2760
aactaatca  gagtgagtg  acaactatt  ataaactag  tctcctatt  ttcagaatg  2820
tcttctacg  ataaatatg  aatgataaa  atgtcaaat  tctcagagg  tatagctgg  2880
aacccgact  tgaaagtat  tgatatctg  acacatact  gaaagctct  catgtgtgt  2940
gtccttcag  ataattcgg  agggaaaac  gtcgatcaa  ggatgtatt  gaacatgtc  3000
gagtagaaa  tgttcctga  gtgccagaa  ttcgaccct  tctctgaga  agatgatcg  3060
gcctataaa  agtaggacc  atgttgtga  taacatcat  aggcttgga  tgaattctc  3120
ctaaaaata  aatgatgta  gatttgttg  tggcatccc  tttattaat  cattaaatt  3180
ctggatttg  gttgtgacc  agggtgcat  aacttaaaa  attcactaa  gcagcacat  3240
gcactggga  ctctggctc  gaaaaactt  gttatatat  tcaaggatg  tctggcttt  3300
cattttatt  attagctgt  aatacatgt  tggatgtgt  aatggagct  gtacatatt  3360
gaaaggtca  tgtggctat  tgcatttat  aatgtgtgg  gctaactgt  tgtgtcttt  3420
tcagtgatg  tctcacaga  ccaactcac  cttatgaaa  gggctttaa  aaaacaaga  3480
agaaacgta  ttaactgtg  gaagaaatg  aatcagctt  taataaaat  gacaacatt  3540
tattaccac  3549



<210> 2765
<211> 475
<212> PRT
<213> Homo sapiens
<308> P06858
<400> 2765

Met Glu Ser Lys Ala Leu Leu Val Leu Thr Leu Ala Val Trp Leu Gln 
  1               5                  10                  15
Ser Leu Thr Ala Ser Arg Gly Gly Val Ala Ala Ala Asp Gln Arg Arg 
             20                  25                  30
Asp Phe Ile Asp Ile Glu Ser Lys Phe Ala Leu Arg Thr Pro Glu Asp 
         35                  40                  45
Thr Ala Glu Asp Thr Cys His Leu Ile Pro Gly Val Ala Glu Ser Val 
     50                  55                  60
Ala Thr Cys His Phe Asn His Ser Ser Lys Thr Phe Met Val Ile His 
 65                  70                  75                  80
Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp Val Pro Lys Leu Val 
                 85                  90                  95
Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser Asn Val Ile Val Val Asp 
             100                105                110
Trp Leu Ser Arg Ala Gln Glu His Tyr Pro Val Ser Ala Gly Tyr Thr 
         115                120                125
Lys Leu Val Gly Gln Asp Val Ala Arg Phe Ile Asn Trp Met Glu Glu 
     130                135                140
Glu Phe Asn Tyr Pro Leu Asp Asn Val His Leu Leu Gly Tyr Ser Leu 
 145                150                155                160
Gly Ala His Ala Ala Gly Ile Ala Gly Ser Leu Thr Asn Lys Lys Val 
                 165                170                175
Asn Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro Asn Phe Glu Tyr Ala 
             180                185                190
Glu Ala Pro Ser Arg Leu Ser Pro Asp Asp Ala Asp Phe Val Asp Val 
         195                200                205
Leu His Thr Phe Thr Arg Gly Ser Pro Gly Arg Ser Ile Gly Ile Gln 
     210                215                220
Lys Pro Val Gly His Val Asp Ile Tyr Pro Asn Gly Gly Thr Phe Gln 
 225                230                235                240
Pro Gly Cys Asn Ile Gly Glu Ala Ile Arg Val Ile Ala Glu Arg Gly 
                 245                250                255
Leu Gly Asp Val Asp Gln Leu Val Lys Cys Ser His Glu Arg Ser Ile 
             260                265                270
His Leu Phe Ile Asp Ser Leu Leu Asn Glu Glu Asn Pro Ser Lys Ala 
         275                280                285
Tyr Arg Cys Ser Ser Lys Glu Ala Phe Glu Lys Gly Leu Cys Leu Ser 
     290                295                300
Cys Arg Lys Asn Arg Cys Asn Asn Leu Gly Tyr Glu Ile Asn Lys Val 
 305                310                315                320
Arg Ala Lys Arg Ser Ser Lys Met Tyr Leu Lys Thr Arg Ser Gln Met 
                 325                330                335
Pro Tyr Lys Val Phe His Tyr Gln Val Lys Ile His Phe Ser Gly Thr 
             340                345                350
Glu Ser Glu Thr His Thr Asn Gln Ala Phe Glu Ile Ser Leu Tyr Gly 
         355                360                365
Thr Val Ala Glu Ser Glu Asn Ile Pro Phe Thr Leu Pro Glu Val Ser 
     370                375                380
Thr Asn Lys Thr Tyr Ser Phe Leu Ile Tyr Thr Glu Val Asp Ile Gly 
 385                390                395                400
Glu Leu Leu Met Leu Lys Leu Lys Trp Lys Ser Asp Ser Tyr Phe Ser 
                 405                410                415
Trp Ser Asp Trp Trp Ser Ser Pro Gly Phe Ala Ile Gln Lys Ile Arg 
             420                425                430
Val Lys Ala Gly Glu Thr Gln Lys Lys Val Ile Phe Cys Ser Arg Glu 
         435                440                445
Lys Val Ser His Leu Gln Lys Gly Lys Ala Pro Ala Val Phe Val Lys 
     450                455                460
Cys His Asp Lys Ser Leu Asn Lys Lys Ser Gly 
 465                470                475



<210> 2766
<211> 3617
<212> DNA
<213> Rattus norvegicus
<308> L03294
<400> 2766

ttctgcccc  tgtagctgt  ctgccctcc  ctttaaagg  tgacttgcc  cgcggcgct  60
caccgcgct  tagtcctct  acgcctccg  ctcaaccct  tgcaacgcg  atccccgcc  120
gcctgactg  ccgcgcagc  cagttccag  agcaaagca  aagggcgcg  cgagatgga  180
agcaaagcc  tgctcctgg  ggccctggg  gtttggctc  agagtttga  cgccttccg  240
ggaggggtg  ccgcagcag  cgggggaag  gatttctca  acatcgaaa  taaatttgc  300
ctaaggacc  ctgaagaca  agctgagga  acttgtcat  tgattcctg  attagcaga  360
tctgtgtct  actgccact  caaccacag  agcaaaacc  ttgtggtga  ccatggatg  420
acggtgaca  gaatgtatg  gagttgggt  cccaaactt  tggctgccc  atacaaaag  480
gaacctgac  ccaatgtca  tgtagtaga  tggttgtat  gggcccagc  acattatcc  540
gtgtctgcc  gctatacca  gctggtggg  aatgatgtg  ccaggttca  caactggct  600
gaggaagaa  ttaactacc  cctagacaa  gtccacctc  tagggtaca  tcttggagc  660
catgctgct  gcgtggcag  aagtctgac  aacaagaag  tcaatagaa  tactggctt  720
gatccagct  ggcctaact  tgagtatgc  gaagcccct  gtcgccttt  tcctgatga  780
gcggatttc  tagatgtct  acacacatt  accaggggg  cgcctggtc  aagtattgg  840
atccagaaa  cagtagggc  tgttgatat  tatcccaat  gaggcactt  ccagccagg  900
tgcaacatt  gagaagcca  tcgtgtaat  gcagagaag  ggcttggag  tgtggacca  960
ctggtgaag  gctcgcacg  gcgctccat  catctcttc  ttgactccc  gctgaatga  1020
gaaaacccc  gcaaggcat  caggtgcaa  tccaaggag  cctttgaga  agggctctg  1080
ctgagttgc  gaaagaatc  ctgtaacaa  gtgggctat  agatcaaca  ggtcagagc  1140
aagagaagc  gtaagatgt  cctgaagac  cgctctcag  tgccctaca  agtattcca  1200
taccaagtc  agattcact  ttctggaac  gagaatgac  agcaaaaca  ccaggcctt  1260
gagatttct  tgtatggca  agtggctga  agtgagaac  ttcccttca  cctgccgga  1320
gtcgccaca  ataaaacct  ctccttctt  atttacacg  aggtggaca  cggggaatt  1380
ctgatgatg  agcttaagt  gaagaacga  tcctacttc  gctggtcag  ctggtggag  1440
agtcccagc  ttgtcatcg  gaagatccg  gtgaaagcc  gagagactc  gaaaaaggt  1500
atcttctgt  ccagggaga  agtttctca  ctgcagaaa  gaaaggacg  tgcagtgtt  1560
gtgaaatgc  atgacaagt  tctgaagaa  tcgggctga  actggacaa  ccaacaaga  1620
aagaaagca  ctgagttct  tgaagaccg  agaaaatga  gtaaatttt  tttaaaaaa  1680
atacccttg  ttgggtgtt  gaaagtgga  tttcctgag  attaatccc  gctatatct  1740
gttagttaa  tagaagaca  tgtcaaata  taaaaggtg  ctaacacaa  gtgaggaac  1800
taatggccg  tagcatgtc  tccagcatc  gaagacagc  gagaggaga  gcatgccat  1860
ttatatccc  taagaagga  tcatttgtt  ccaaccata  aagactcct  catgtgacc  1920
atttggtca  ggtctaaaa  tagtaaggg  ctcttattt  cattagatc  ctgaggttt  1980
aaattgaga  cttctcaaa  ttctcttga  gtctaatat  gacaacatt  ttttgtgct  2040
tgagtcaga  ccatttctt  agcagttga  acagctggc  attgtaact  gttctttta  2100
catcaggat  tagcacccc  accaaataa  ataaataaa  aaagtgacc  gggacatgt  2160
actttgcaa  agcaatgga  gacgtggct  gtggattcc  gacccttag  cccaccaca  2220
cgaagtaca  gtcagtaga  gtacaaaac  tagactgag  aattcttag  agacttcaa  2280
ttttatggc  taattcctc  gtcttttaa  aacgtgtca  atattataa  attattctc  2340
agacagatg  tgaaatgag  ttgtgattc  ggtgacata  gaattgagc  gagagaaaa  2400
aatgccctg  ctgatttta  ttctctgtt  tgctttctt  agaaaagga  tacttgtcc  2460
actccgtat  tgagcctga  caagaacta  actatgtac  tcaggctta  cttgaactc  2520
caaccatcc  gccttggct  cctgagtgc  gggagcttg  taaccataa  tttattatc  2580
gatttttct  agtcatttt  accaataga  cacattcaa  gcccaatcg  tagcatttc  2640
tttgagact  atcttgacc  tacctctgt  acacgtcta  cacatcaca  taatttcta  2700
tttagaagt  atcaagttc  aattctgca  tgcgcaaag  acaagtttt  gagcaggac  2760
atttttttt  taccacgta  aagtcgaaa  tactaggaa  tgtgtatat  gatgcttgt  2820
cactgttgc  tgcaaagtg  ggagccttc  attgtgata  ccatagaca  taccaggct  2880
gttgccgct  ttttgtttt  ctataaaaa  ataatgaag  attatttat  aacaagatc  2940
catatgttc  gattgcttt  actattcat  aatataaaa  gttaaaaaa  aaaaataaa  3000
caagttcta  ctcagaggc  gttgctggg  acagaaact  tgaaatgtg  gggtatctg  3060
acacctaca  acaagcaaa  ccccacaag  gtctttgtc  ttcaatgtc  ttcagaaag  3120
aaagagtca  gagatatac  ataatatgt  agagaagta  ttccagata  gctggaatg  3180
tagcccttg  taggagaaa  ttggttgtg  ctatgtaat  taggacaaa  gtgactggt  3240
tcattaggc  cagtgtcat  ctaacaata  aatgatgta  catatgtca  cagcatccc  3300
attattgct  attcatggc  gtatatacg  acatatctc  atgatgctt  gactttaaa  3360
tttatttat  agctgtaaa  aatgtgtgg  tgtgtaagg  agcttgtaa  cactggaaa  3420
gctgttgtg  ctatctggg  tgtagattt  tggtgctaa  tctgtgtcc  cctccatca  3480
tgattgtct  actgagcca  ctcactctg  tgaacagca  aatggaata  cttttgaag  3540
aagaaaata  actcacctg  gtgaagaaa  gggatctgc  ttcaataaa  tcgagaacg  3600
tttatccgg  atccgcg  3617



<210> 2767
<211> 474
<212> PRT
<213> Rattus norvegicus
<308> Q06000
<400> 2767

Met Glu Ser Lys Ala Leu Leu Leu Val Ala Leu Gly Val Trp Leu Gln 
  1               5                  10                  15
Ser Leu Thr Ala Phe Arg Gly Gly Val Ala Ala Ala Asp Gly Gly Arg 
             20                  25                  30
Asp Phe Ser Asp Ile Glu Ser Lys Phe Ala Leu Arg Thr Pro Glu Asp 
         35                  40                  45
Thr Ala Glu Asp Thr Cys His Leu Ile Pro Gly Leu Ala Asp Ser Val 
     50                  55                  60
Ser Asn Cys His Phe Asn His Ser Ser Lys Thr Phe Val Val Ile His 
 65                  70                  75                  80
Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp Val Pro Lys Leu Val 
                 85                  90                  95
Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser Asn Val Ile Val Val Asp 
             100                105                110
Trp Leu Tyr Arg Ala Gln Gln His Tyr Pro Val Ser Ala Gly Tyr Thr 
         115                120                125
Lys Leu Val Gly Asn Asp Val Ala Arg Phe Ile Asn Trp Leu Glu Glu 
     130                135                140
Glu Phe Asn Tyr Pro Leu Asp Asn Val His Leu Leu Gly Tyr Ser Leu 
 145                150                155                160
Gly Ala His Ala Ala Gly Val Ala Gly Ser Leu Thr Asn Lys Lys Val 
                 165                170                175
Asn Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro Asn Phe Glu Tyr Ala 
             180                185                190
Glu Ala Pro Ser Arg Leu Ser Pro Asp Asp Ala Asp Phe Val Asp Val 
         195                200                205
Leu His Thr Phe Thr Arg Gly Ser Pro Gly Arg Ser Ile Gly Ile Gln 
     210                215                220
Lys Pro Val Gly His Val Asp Ile Tyr Pro Asn Gly Gly Thr Phe Gln 
 225                230                235                240
Pro Gly Cys Asn Ile Gly Glu Ala Ile Arg Val Ile Ala Glu Lys Gly 
                 245                250                255
Leu Gly Asp Val Asp Gln Leu Val Lys Cys Ser His Glu Arg Ser Ile 
             260                265                270
His Leu Phe Ile Asp Ser Leu Leu Asn Glu Glu Asn Pro Ser Lys Ala 
         275                280                285
Tyr Arg Cys Asn Ser Lys Glu Ala Phe Glu Lys Gly Leu Cys Leu Ser 
     290                295                300
Cys Arg Lys Asn Arg Cys Asn Asn Val Gly Tyr Glu Ile Asn Lys Val 
 305                310                315                320
Arg Ala Lys Arg Ser Ser Lys Met Tyr Leu Lys Thr Arg Ser Gln Met 
                 325                330                335
Pro Tyr Lys Val Phe His Tyr Gln Val Lys Ile His Phe Ser Gly Thr 
             340                345                350
Glu Asn Asp Lys Gln Asn Asn Gln Ala Phe Glu Ile Ser Leu Tyr Gly 
         355                360                365
Thr Val Ala Glu Ser Glu Asn Ile Pro Phe Thr Leu Pro Glu Val Ala 
     370                375                380
Thr Asn Lys Thr Tyr Ser Phe Leu Ile Tyr Thr Glu Val Asp Ile Gly 
 385                390                395                400
Glu Leu Leu Met Met Lys Leu Lys Trp Lys Asn Asp Ser Tyr Phe Arg 
                 405                410                415
Trp Ser Asp Trp Trp Ser Ser Pro Ser Phe Val Ile Glu Lys Ile Arg 
             420                425                430
Val Lys Ala Gly Glu Thr Gln Lys Lys Val Ile Phe Cys Ala Arg Glu 
         435                440                445
Lys Val Ser His Leu Gln Lys Gly Lys Asp Ala Ala Val Phe Val Lys 
     450                455                460
Cys His Asp Lys Ser Leu Lys Lys Ser Gly 
 465                470



<210> 2768
<211> 3549
<212> DNA
<213> Homo sapiens
<308> M15856
<400> 2768

cccctcttc  tcctcctca  gggaaagct  cccacttct  gctgccctg  catcccctt  60
aaagggcga  ttgctcagc  ccaaaccgc  gctccagcc  tctccagcc  ccggctcag  120
cggctcatc  gtcggtccg  gccttgcag  tcctccaga  ggacgcgcc  cgagatgga  180
agcaaagcc  tgctcgtgc  gactctggc  gtgtggctc  agagtctga  cgcctcccg  240
ggaggggtg  ccgccgccg  ccaaagaag  gattttatc  acatcgaaa  taaatttgc  300
ctaaggacc  ctgaagaca  agctgagga  acttgccac  tcattcccg  agtagcaga  360
tccgtggct  cctgtcatt  caatcacag  agcaaaacc  tcatggtga  ccatggctg  420
acggtaaca  gaatgtatg  gagttgggt  ccaaaactt  tggccgccc  gtacaagag  480
gaaccagac  ccaatgtca  tgtggtgga  tggctgtca  gggctcagg  gcattaccc  540
gtgtccgcg  gctacacca  actggtggg  caggatgtg  cccggttta  caactggat  600
gaggaggag  ttaactacc  tctggacaa  gtccatctc  tgggataca  ccttggagc  660
catgctgct  gcattgcag  aagtctgac  aataagaaa  tcaacagaa  tactggcct  720
gatccagct  gacctaact  tgagtatgc  gaagccccg  gtcgtcttt  tcctgatga  780
gcagatttt  tagacgtct  acacacatt  accagaggg  cccctggtc  aagcattgg  840
atccagaaa  cagttgggc  tgttgacat  tacccgaat  gaggtactt  tcagccagg  900
tgtaacatt  gagaagcta  ccgcgtgat  gcagagaga  gacttggag  tgtggacca  960
ctagtgaag  gctcccacg  gcgctccat  catctcttc  tcgactctc  gttgaatga  1020
gaaaatcca  gtaaggcct  caggtgcag  tccaaggaa  cctttgaga  agggctctg  1080
ttgagttgt  gaaagaacc  ctgcaacaa  ctgggctat  agatcaata  agtcagagc  1140
aaaagaagc  gcaaaatgt  cctgaagac  cgttctcag  tgccctaca  agtcttcca  1200
taccaagta  agattcatt  ttctgggac  gagagtgaa  cccatacca  tcaggcctt  1260
gagatttct  tgtatggca  cgtggccga  agtgagaac  tcccattca  tctgcctga  1320
gtttccaca  ataagacct  ctccttcct  atttacaca  aggtagata  tggagaact  1380
ctcatgttg  agctcaaat  gaagagtga  tcatacttt  gctggtcag  ctggtggag  1440
agtcccggc  tcgccattc  gaagatcag  gtaaaagca  gagagactc  gaaaaaggt  1500
atcttctgt  ctagggaga  agtgtctca  ttgcagaaa  gaaaggcac  tgcggtatt  1560
gtgaaatgc  atgacaagt  tctgaataa  aagtcaggc  gaaactggg  gaatctaca  1620
aacaaagaa  ggcatgtga  ttctgtgaa  aatgaagtg  aggaagtaa  ttttacaaa  1680
catacccag  gtttggggt  tttcaaaag  ggattttcc  gaatattaa  cccagccct  1740
cccttgtta  ttattttag  agacagtct  aagcactaa  aagtggcta  ttcaattta  1800
ggggtatag  ggccaaata  cacatcctc  aacgttaaa  gacagtgga  catgaaaag  1860
gctgttttg  cctttgaga  agaaataat  gtttgagcg  agagtaaaa  aaggctcct  1920
catgtggcg  attgggcca  agcctataa  tggttagaa  ctcctattt  aattggaat  1980
ctggatctt  cggactgag  ccttctcaa  ctttactct  agtctccaa  aatacagaa  2040
atgcttttc  gcggcacga  tcagactca  ctacacagc  gtatgaatg  tgttttaga  2100
tgattccct  ttgctattg  aatgtggtc  agacgtcaa  caggaacat  taacttgga  2160
agggacgaa  aaagggtct  ataaacaca  aggttttaa  cagtcccta  cattggcct  2220
catcatgac  aagttacaa  ttcaaggag  tataaaatc  agatcaatt  attcttaat  2280
ggctttatc  tttattgct  aatccctct  tcccccttc  tttttgtct  aagattata  2340
tataataat  ttctctggg  aggtgttga  aatgagcct  taatcctca  ctgacacat  2400
atttgaatg  tgcagaaaa  aaaaagata  cgtaatttt  ttattagat  ctccaaatg  2460
ttttcatca  tttaaaatc  ttcaatatc  gacagttac  cttcagttt  aggcttacc  2520
tggtcatgc  tcagttgta  ttccagtgc  tctcttttg  tcctggctt  gacatgaaa  2580
gataggttt  agttcaaat  ttgcattgt  tgagcttct  cagatttta  acaaggacc  2640
tttttacta  gtaaaaggg  ggagaggtt  ctggggtgg  ttcctaagc  gtgcttgta  2700
accatcgcg  gcaatgagc  agatggagt  ccatgaggg  tgttatttg  tgtttttaa  2760
aactaatca  gagtgagtg  acaactatt  ataaactag  tctcctatt  ttcagaatg  2820
tcttctacg  ataaatatg  aatgataaa  atgtcaaat  tctcagagg  tatagctgg  2880
aacccgact  tgaaagtat  tgatatctg  acacatact  gaaagctct  catgtgtgt  2940
gtccttcag  ataattcgg  agggaaaac  gtcgatcaa  ggatgtatt  gaacatgtc  3000
gagtagaaa  tgttcctga  gtgccagaa  ttcgaccct  tctctgaga  agatgatcg  3060
gcctataaa  agtaggacc  atgttgtga  taacatcat  aggcttgga  tgaattctc  3120
ctaaaaata  aatgatgta  gatttgttg  tggcatccc  tttattaat  cattaaatt  3180
ctggatttg  gttgtgacc  agggtgcat  aacttaaaa  attcactaa  gcagcacat  3240
gcactggga  ctctggctc  gaaaaactt  gttatatat  tcaaggatg  tctggcttt  3300
cattttatt  attagctgt  aatacatgt  tggatgtgt  aatggagct  gtacatatt  3360
gaaaggtca  tgtggctat  tgcatttat  aatgtgtgg  gctaactgt  tgtgtcttt  3420
tcagtgatg  tctcacaga  ccaactcac  cttatgaaa  gggctttaa  aaaacaaga  3480
agaaacgta  ttaactgtg  gaagaaatg  aatcagctt  taataaaat  gacaacatt  3540
tattaccac  3549



<210> 2769
<211> 475
<212> PRT
<213> Homo sapiens
<308> P06858
<400> 2769

Met Glu Ser Lys Ala Leu Leu Val Leu Thr Leu Ala Val Trp Leu Gln 
  1               5                  10                  15
Ser Leu Thr Ala Ser Arg Gly Gly Val Ala Ala Ala Asp Gln Arg Arg 
             20                  25                  30
Asp Phe Ile Asp Ile Glu Ser Lys Phe Ala Leu Arg Thr Pro Glu Asp 
         35                  40                  45
Thr Ala Glu Asp Thr Cys His Leu Ile Pro Gly Val Ala Glu Ser Val 
     50                  55                  60
Ala Thr Cys His Phe Asn His Ser Ser Lys Thr Phe Met Val Ile His 
 65                  70                  75                  80
Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp Val Pro Lys Leu Val 
                 85                  90                  95
Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser Asn Val Ile Val Val Asp 
             100                105                110
Trp Leu Ser Arg Ala Gln Glu His Tyr Pro Val Ser Ala Gly Tyr Thr 
         115                120                125
Lys Leu Val Gly Gln Asp Val Ala Arg Phe Ile Asn Trp Met Glu Glu 
     130                135                140
Glu Phe Asn Tyr Pro Leu Asp Asn Val His Leu Leu Gly Tyr Ser Leu 
 145                150                155                160
Gly Ala His Ala Ala Gly Ile Ala Gly Ser Leu Thr Asn Lys Lys Val 
                 165                170                175
Asn Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro Asn Phe Glu Tyr Ala 
             180                185                190
Glu Ala Pro Ser Arg Leu Ser Pro Asp Asp Ala Asp Phe Val Asp Val 
         195                200                205
Leu His Thr Phe Thr Arg Gly Ser Pro Gly Arg Ser Ile Gly Ile Gln 
     210                215                220
Lys Pro Val Gly His Val Asp Ile Tyr Pro Asn Gly Gly Thr Phe Gln 
 225                230                235                240
Pro Gly Cys Asn Ile Gly Glu Ala Ile Arg Val Ile Ala Glu Arg Gly 
                 245                250                255
Leu Gly Asp Val Asp Gln Leu Val Lys Cys Ser His Glu Arg Ser Ile 
             260                265                270
His Leu Phe Ile Asp Ser Leu Leu Asn Glu Glu Asn Pro Ser Lys Ala 
         275                280                285
Tyr Arg Cys Ser Ser Lys Glu Ala Phe Glu Lys Gly Leu Cys Leu Ser 
     290                295                300
Cys Arg Lys Asn Arg Cys Asn Asn Leu Gly Tyr Glu Ile Asn Lys Val 
 305                310                315                320
Arg Ala Lys Arg Ser Ser Lys Met Tyr Leu Lys Thr Arg Ser Gln Met 
                 325                330                335
Pro Tyr Lys Val Phe His Tyr Gln Val Lys Ile His Phe Ser Gly Thr 
             340                345                350
Glu Ser Glu Thr His Thr Asn Gln Ala Phe Glu Ile Ser Leu Tyr Gly 
         355                360                365
Thr Val Ala Glu Ser Glu Asn Ile Pro Phe Thr Leu Pro Glu Val Ser 
     370                375                380
Thr Asn Lys Thr Tyr Ser Phe Leu Ile Tyr Thr Glu Val Asp Ile Gly 
 385                390                395                400
Glu Leu Leu Met Leu Lys Leu Lys Trp Lys Ser Asp Ser Tyr Phe Ser 
                 405                410                415
Trp Ser Asp Trp Trp Ser Ser Pro Gly Phe Ala Ile Gln Lys Ile Arg 
             420                425                430
Val Lys Ala Gly Glu Thr Gln Lys Lys Val Ile Phe Cys Ser Arg Glu 
         435                440                445
Lys Val Ser His Leu Gln Lys Gly Lys Ala Pro Ala Val Phe Val Lys 
     450                455                460
Cys His Asp Lys Ser Leu Asn Lys Lys Ser Gly 
 465                470                475



<210> 2770
<211> 985
<212> DNA
<213> Rattus norvegicus
<308> L03556
<400> 2770

tgcacaatt  tggagatca  agttccgtg  gcgaacaat  cagggactc  gcgagcatg  60
actccggca  gtacggcta  ggctacaat  gcatggatc  cagcgtcgg  cgttcgggt  120
ccggccact  tggctccgg  gagckckcc  gcagctacn  ggctggggc  agtgcggcg  180
ccgccgagc  caggtacag  cagccggcc  cgtccacgc  ctcgccacc  cccgacccg  240
tgccctgct  agcggtggc  cccttgccc  gcagcgaca  gcaccacgg  gggaaaaac  300
ccctgggca  ctccagcgg  tgctcggcc  actgcggca  cacccacat  agcagcaga  360
agggggttg  cacggcgtc  gcagcggag  aggacgccc  tgccagcag  gagcaggcg  420
gcgcccaga  cgagccgag  ccggcgccg  ccgctcaac  ccagatcta  ccctggatg  480
gcaagctgc  cattagtca  gacaacata  gtggcccag  aggcaaaag  gcccggacg  540
gctacactc  ctaccagac  ctggagctg  agaaagaat  ccacttcaa  cgctacctg  600
cccgccgaa  aaggattga  atagcacat  ccctttgcc  ctccgagag  caaattaaa  660
tctggttcc  aaacaggag  atgaagtgg  aaaaggata  atagctgaa  agtatgagt  720
tggccgcgg  agggggggc  ttccgcccc  gaggttctg  gcggccaaa  tactgggca  780
tagtagcgc  cggacgaac  ctccgtagt  tcagtacta  ggtgacttt  tgaaactcc  840
cttgtgttc  ttctgtgaa  aagccctgt  ctcgttgcc  taattcatc  tttaatcat  900
agcctgttt  ttgccatta  agcgcctgt  taagtagat  agcttctgt  catctcttt  960
ctgatgctt  tcgaaaaaa  tagag  985



<210> 2771
<211> 233
<212> PRT
<213> Rattus norvegicus
<308> P52949
<400> 2771

His Asn Tyr Gly Asp His Ser Ser Val Ser Glu Gln Phe Arg Asp Ser 
  1               5                  10                  15
Ala Ser Met His Ser Gly Arg Tyr Gly Tyr Gly Tyr Asn Gly Met Asp 
             20                  25                  30
Leu Ser Val Gly Arg Ser Gly Ser Gly His Phe Gly Ser Gly Glu Xaa 
         35                  40                  45
Xaa Arg Ser Tyr Xaa Ala Gly Ala Ser Ala Ala Pro Ala Glu Pro Arg 
     50                  55                  60
Tyr Ser Gln Pro Ala Thr Ser Thr His Ser Pro Pro Pro Asp Pro Leu 
 65                  70                  75                  80
Pro Cys Ser Ala Val Ala Pro Leu Pro Gly Ser Asp Thr His His Gly 
                 85                  90                  95
Gly Lys Asn Ser Leu Gly Asn Ser Ser Gly Cys Ser Ala Asn Cys Gly 
             100                105                110
Ser Thr His Ile Ser Ser Arg Glu Gly Val Gly Thr Ala Ser Ala Ala 
         115                120                125
Glu Glu Asp Ala Pro Ala Ser Ser Glu Gln Ala Gly Ala Gln Ser Glu 
     130                135                140
Pro Ser Pro Ala Pro Pro Ala Gln Pro Gln Ile Tyr Pro Trp Met Arg 
 145                150                155                160
Lys Leu His Ile Ser His Asp Asn Ile Gly Gly Pro Glu Gly Lys Arg 
                 165                170                175
Ala Arg Thr Cys Tyr Thr Arg Tyr Gln Thr Leu Glu Leu Glu Lys Glu 
             180                185                190
Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala 
         195                200                205
His Ala Leu Cys Leu Ser Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn 
     210                215                220
Arg Arg Met Lys Trp Lys Lys Asp Lys 
 225                230



<210> 2772
<211> 1160
<212> DNA
<213> Homo sapiens
<308> BC013682
<400> 2772

gcacaaacg  ccgcgagcc  caaatcaag  acacatatc  aaaaacaaa  gagctctta  60
tttgtaaac  cattttgcg  tcgctatcc  aatggcccg  actaccagt  gcataatta  120
ggagatcat  gttccgtga  cgagcaatt  agggactcg  cgagcatgc  ctccggcag  180
tacggctac  gctacaatg  catggatct  agcgtcggc  gctcgggct  cggccactt  240
ggctccgga  agcgcgccc  cagctacgc  gccagcgcc  gcgcggcgc  cgccgagcc  300
aggtacagc  agccggcca  gtccacgca  tctcctcag  ccgatccgc  gccctgctc  360
gccgtggcc  cctcgcccg  cagcgacag  caccacggc  ggaaaaact  cctaagcaa  420
tccagcggc  cctcggccg  cgccggcag  acccacatc  gcagcagag  gggggttgg  480
acggcgtcc  gagccgagg  ggacgcccc  gccagcagc  agcaggcga  tgcgcagag  540
gagccgagc  cggcgccgc  cgcccaacc  cagatctac  cctggatgc  caagctgca  600
ataagtcat  acaacatag  cggcccgga  ggcaaaagg  cccggacgg  ctacacgcg  660
taccagacc  tggagctgg  gaaggagtt  cacttcaac  gttacctga  ccgcagaag  720
aggattgaa  tagcacatg  tctttgcct  tccgagaga  aaattaaaa  ctggttcca  780
aaccggaga  tgaagtgga  aaaagataa  aagctgaaa  gcatgagca  ggccgcggc  840
ggaggggcc  tccgtccct  agtatctga  cgtttaaag  actgagcag  attagcgga  900
cccgcgtag  gtcagtact  aggtgactt  ctgaaactc  cttgtgttc  ttctgtgaa  960
aagccctgt  ctcgttgcc  taattcatc  tttaatcat  agcctgttt  ttgccatta  1020
agcgcctgt  taagtagat  tgctttctg  tcatctctt  gtcctgaat  gctttgtct  1080
gaaaaaaaa  agatgtttt  acttattta  atgaagcaa  ctgtgttac  tgaagtaac  1140
ataacaaaa  aaaaaaaaaa  1160



<210> 2773
<211> 270
<212> PRT
<213> Homo sapiens
<308> P20719
<400> 2773

Met Ser Ser Tyr Phe Val Asn Ser Phe Cys Gly Arg Tyr Pro Asn Gly 
  1               5                  10                  15
Pro Asp Tyr Gln Leu His Asn Tyr Gly Asp His Ser Ser Val Ser Glu 
             20                  25                  30
Gln Phe Arg Asp Ser Ala Ser Met His Ser Gly Arg Tyr Gly Tyr Gly 
         35                  40                  45
Tyr Asn Gly Met Asp Leu Ser Val Gly Arg Ser Gly Ser Gly His Phe 
     50                  55                  60
Gly Ser Gly Glu Arg Ala Arg Ser Tyr Ala Ala Ser Ala Ser Ala Ala 
 65                  70                  75                  80
Pro Ala Glu Pro Arg Tyr Ser Gln Pro Ala Thr Ser Thr His Ser Pro 
                 85                  90                  95
Gln Pro Asp Pro Leu Pro Cys Ser Ala Val Ala Pro Ser Pro Gly Ser 
             100                105                110
Asp Thr His His Gly Gly Lys Asn Ser Leu Ser Asn Ser Ser Gly Ala 
         115                120                125
Ser Ala Asp Ala Gly Ser Thr His Ile Ser Ser Arg Glu Gly Val Gly 
     130                135                140
Thr Ala Ser Gly Ala Glu Glu Asp Ala Pro Ala Ser Ser Glu Gln Ala 
 145                150                155                160
Ser Ala Gln Ser Glu Pro Ser Pro Ala Pro Pro Ala Gln Pro Gln Ile 
                 165                170                175
Tyr Pro Trp Met Arg Lys Leu His Ile Ser His Asp Asn Ile Gly Gly 
             180                185                190
Pro Glu Gly Lys Arg Ala Arg Thr Ala Tyr Thr Arg Tyr Gln Thr Leu 
         195                200                205
Glu Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg 
     210                215                220
Arg Ile Glu Ile Ala His Ala Leu Cys Leu Ser Glu Arg Gln Ile Lys 
 225                230                235                240
Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Asp Asn Lys Leu 
                 245                250                255
Lys Ser Met Ser Met Ala Ala Ala Gly Gly Ala Phe Arg Pro 
             260                265                270



<210> 2774
<211> 985
<212> DNA
<213> Rattus norvegicus
<308> L03556
<400> 2774

tgcacaatt  tggagatca  agttccgtg  gcgaacaat  cagggactc  gcgagcatg  60
actccggca  gtacggcta  ggctacaat  gcatggatc  cagcgtcgg  cgttcgggt  120
ccggccact  tggctccgg  gagckckcc  gcagctacn  ggctggggc  agtgcggcg  180
ccgccgagc  caggtacag  cagccggcc  cgtccacgc  ctcgccacc  cccgacccg  240
tgccctgct  agcggtggc  cccttgccc  gcagcgaca  gcaccacgg  gggaaaaac  300
ccctgggca  ctccagcgg  tgctcggcc  actgcggca  cacccacat  agcagcaga  360
agggggttg  cacggcgtc  gcagcggag  aggacgccc  tgccagcag  gagcaggcg  420
gcgcccaga  cgagccgag  ccggcgccg  ccgctcaac  ccagatcta  ccctggatg  480
gcaagctgc  cattagtca  gacaacata  gtggcccag  aggcaaaag  gcccggacg  540
gctacactc  ctaccagac  ctggagctg  agaaagaat  ccacttcaa  cgctacctg  600
cccgccgaa  aaggattga  atagcacat  ccctttgcc  ctccgagag  caaattaaa  660
tctggttcc  aaacaggag  atgaagtgg  aaaaggata  atagctgaa  agtatgagt  720
tggccgcgg  agggggggc  ttccgcccc  gaggttctg  gcggccaaa  tactgggca  780
tagtagcgc  cggacgaac  ctccgtagt  tcagtacta  ggtgacttt  tgaaactcc  840
cttgtgttc  ttctgtgaa  aagccctgt  ctcgttgcc  taattcatc  tttaatcat  900
agcctgttt  ttgccatta  agcgcctgt  taagtagat  agcttctgt  catctcttt  960
ctgatgctt  tcgaaaaaa  tagag  985



<210> 2775
<211> 233
<212> PRT
<213> Rattus norvegicus
<308> P52949
<400> 2775

His Asn Tyr Gly Asp His Ser Ser Val Ser Glu Gln Phe Arg Asp Ser 
  1               5                  10                  15
Ala Ser Met His Ser Gly Arg Tyr Gly Tyr Gly Tyr Asn Gly Met Asp 
             20                  25                  30
Leu Ser Val Gly Arg Ser Gly Ser Gly His Phe Gly Ser Gly Glu Xaa 
         35                  40                  45
Xaa Arg Ser Tyr Xaa Ala Gly Ala Ser Ala Ala Pro Ala Glu Pro Arg 
     50                  55                  60
Tyr Ser Gln Pro Ala Thr Ser Thr His Ser Pro Pro Pro Asp Pro Leu 
 65                  70                  75                  80
Pro Cys Ser Ala Val Ala Pro Leu Pro Gly Ser Asp Thr His His Gly 
                 85                  90                  95
Gly Lys Asn Ser Leu Gly Asn Ser Ser Gly Cys Ser Ala Asn Cys Gly 
             100                105                110
Ser Thr His Ile Ser Ser Arg Glu Gly Val Gly Thr Ala Ser Ala Ala 
         115                120                125
Glu Glu Asp Ala Pro Ala Ser Ser Glu Gln Ala Gly Ala Gln Ser Glu 
     130                135                140
Pro Ser Pro Ala Pro Pro Ala Gln Pro Gln Ile Tyr Pro Trp Met Arg 
 145                150                155                160
Lys Leu His Ile Ser His Asp Asn Ile Gly Gly Pro Glu Gly Lys Arg 
                 165                170                175
Ala Arg Thr Cys Tyr Thr Arg Tyr Gln Thr Leu Glu Leu Glu Lys Glu 
             180                185                190
Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala 
         195                200                205
His Ala Leu Cys Leu Ser Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn 
     210                215                220
Arg Arg Met Lys Trp Lys Lys Asp Lys 
 225                230



<210> 2776
<211> 1160
<212> DNA
<213> Homo sapiens
<308> BC013682
<400> 2776

gcacaaacg  ccgcgagcc  caaatcaag  acacatatc  aaaaacaaa  gagctctta  60
tttgtaaac  cattttgcg  tcgctatcc  aatggcccg  actaccagt  gcataatta  120
ggagatcat  gttccgtga  cgagcaatt  agggactcg  cgagcatgc  ctccggcag  180
tacggctac  gctacaatg  catggatct  agcgtcggc  gctcgggct  cggccactt  240
ggctccgga  agcgcgccc  cagctacgc  gccagcgcc  gcgcggcgc  cgccgagcc  300
aggtacagc  agccggcca  gtccacgca  tctcctcag  ccgatccgc  gccctgctc  360
gccgtggcc  cctcgcccg  cagcgacag  caccacggc  ggaaaaact  cctaagcaa  420
tccagcggc  cctcggccg  cgccggcag  acccacatc  gcagcagag  gggggttgg  480
acggcgtcc  gagccgagg  ggacgcccc  gccagcagc  agcaggcga  tgcgcagag  540
gagccgagc  cggcgccgc  cgcccaacc  cagatctac  cctggatgc  caagctgca  600
ataagtcat  acaacatag  cggcccgga  ggcaaaagg  cccggacgg  ctacacgcg  660
taccagacc  tggagctgg  gaaggagtt  cacttcaac  gttacctga  ccgcagaag  720
aggattgaa  tagcacatg  tctttgcct  tccgagaga  aaattaaaa  ctggttcca  780
aaccggaga  tgaagtgga  aaaagataa  aagctgaaa  gcatgagca  ggccgcggc  840
ggaggggcc  tccgtccct  agtatctga  cgtttaaag  actgagcag  attagcgga  900
cccgcgtag  gtcagtact  aggtgactt  ctgaaactc  cttgtgttc  ttctgtgaa  960
aagccctgt  ctcgttgcc  taattcatc  tttaatcat  agcctgttt  ttgccatta  1020
agcgcctgt  taagtagat  tgctttctg  tcatctctt  gtcctgaat  gctttgtct  1080
gaaaaaaaa  agatgtttt  acttattta  atgaagcaa  ctgtgttac  tgaagtaac  1140
ataacaaaa  aaaaaaaaaa  1160



<210> 2777
<211> 270
<212> PRT
<213> Homo sapiens
<308> P20719
<400> 2777

Met Ser Ser Tyr Phe Val Asn Ser Phe Cys Gly Arg Tyr Pro Asn Gly 
  1               5                  10                  15
Pro Asp Tyr Gln Leu His Asn Tyr Gly Asp His Ser Ser Val Ser Glu 
             20                  25                  30
Gln Phe Arg Asp Ser Ala Ser Met His Ser Gly Arg Tyr Gly Tyr Gly 
         35                  40                  45
Tyr Asn Gly Met Asp Leu Ser Val Gly Arg Ser Gly Ser Gly His Phe 
     50                  55                  60
Gly Ser Gly Glu Arg Ala Arg Ser Tyr Ala Ala Ser Ala Ser Ala Ala 
 65                  70                  75                  80
Pro Ala Glu Pro Arg Tyr Ser Gln Pro Ala Thr Ser Thr His Ser Pro 
                 85                  90                  95
Gln Pro Asp Pro Leu Pro Cys Ser Ala Val Ala Pro Ser Pro Gly Ser 
             100                105                110
Asp Thr His His Gly Gly Lys Asn Ser Leu Ser Asn Ser Ser Gly Ala 
         115                120                125
Ser Ala Asp Ala Gly Ser Thr His Ile Ser Ser Arg Glu Gly Val Gly 
     130                135                140
Thr Ala Ser Gly Ala Glu Glu Asp Ala Pro Ala Ser Ser Glu Gln Ala 
 145                150                155                160
Ser Ala Gln Ser Glu Pro Ser Pro Ala Pro Pro Ala Gln Pro Gln Ile 
                 165                170                175
Tyr Pro Trp Met Arg Lys Leu His Ile Ser His Asp Asn Ile Gly Gly 
             180                185                190
Pro Glu Gly Lys Arg Ala Arg Thr Ala Tyr Thr Arg Tyr Gln Thr Leu 
         195                200                205
Glu Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg 
     210                215                220
Arg Ile Glu Ile Ala His Ala Leu Cys Leu Ser Glu Arg Gln Ile Lys 
 225                230                235                240
Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Asp Asn Lys Leu 
                 245                250                255
Lys Ser Met Ser Met Ala Ala Ala Gly Gly Ala Phe Arg Pro 
             260                265                270



<210> 2778
<211> 3559
<212> DNA
<213> Rattus norvegicus
<308> L04739
<400> 2778

atgcaggag  tctcgttgc  tctctggta  agataaacg  acacaccag  agtttttaa  60
accttaagt  ctttcccct  tgttatagc  tatttcaac  attccaacc  gccgcttaa  120
gtttctaaa  gaagctggc  atgggacac  gaaggaaga  atccctgag  aggaattgg  180
ggaggatgt  gaagagatt  accatgccg  acgggagtt  cggcgtggc  agatcttgt  240
gtttagagg  ctgaacaga  tccaaacac  ggtatgggt  tggtagaga  gtaggagag  300
tgatggggt  aggacgttc  cctgggaga  gcccgaatg  gcttttaac  gccttgcca  360
gcttcccga  ccacaaagt  tattccttt  aaaaacacc  actgatgac  gaattgagt  420
aagctttta  ctgaatatg  aagaatgtc  cttataagc  ctcagcttt  tttttccct  480
gcctttatt  tcccctttc  tctcaaaat  ctacatctt  cctatttat  tgctctgta  540
aagtgcctt  tcctatacg  tttaaatgt  ggttgatgg  acggtcctt  ctctgttct  600
tctctcttg  tgagcaagc  gtcacgatc  ctgattcct  gcagatgga  gtagtgaat  660
ctttccaga  tggaggttc  attcagggg  ctctaaggc  acaaccctc  atcgccaga  720
agcaccatg  tggtaacaa  tgttctacc  ctacacatg  agtgtttcc  cttctactg  780
ttctactcc  gtggggtgt  agtgtgtgt  cctaagtgc  tgaaattaa  atttcctac  840
cctcacacc  aacgtttct  attctctcc  tactgttta  actcattgt  cgggctttt  900
cataaagct  tctttttgt  aagtggact  gacctcaag  gttgccatt  ttgtttcat  960
tcttagagg  ttggaggaa  ggtgggtca  ttgcaacca  agaatacac  cgaaatcag  1020
gagcttgtc  ctatgctaa  tctcagagc  catagcggg  agtaaagtt  cagtttagt  1080
cttatgaaa  gactataaa  gtttgagta  atacctttc  acatattca  actgcatgg  1140
tcccagaag  atgtgatct  aaactgagc  aacagaacc  gaaaattac  tgtacaacg  1200
caaagaatg  acttggcat  tcagctcat  cattgtcct  tgagagagt  agttagcag  1260
atgaagcga  gctctcgct  gctagccag  tgcttgcct  cctaacttg  actctgtct  1320
ccttgatcc  gtgtgccac  gaataagct  tcatcattt  tacgctccc  atattggtc  1380
atttcttgg  cttttccct  ttgtacaat  actacagtc  gcttggaag  gcatcgtag  1440
caataccct  atgttacaa  gttgacggt  tattcgctg  tgttggtct  ttagttaaa  1500
tagaaacgc  cgatgaagt  gaatgatga  atagcataa  aaagtcaaa  gaaatatgt  1560
caggctgca  ttggttatg  atgcagaaa  gcagactgt  taggtagga  ctctcctgg  1620
tcagagtct  cctttcccc  aatatcccc  gtcaatcaa  tgcacacca  agtctgaga  1680
agatcttgg  cttgattat  tatgctaac  ctgcaccac  ttccatagc  accccatgg  1740
gtggtgggg  attacatct  atttcctgg  gaaatgcca  ttggccacc  ctccccctc  1800
tcaagtagg  aggagggga  ctcattcca  gcctccctt  ctcactcag  tatatttac  1860
ctctgtgca  agggccaag  tatttagaa  gatggttct  aacctccct  acactgcag  1920
ccggtgaac  ccatcataa  attaccttt  ttgcttctg  acaactgta  ttttgctac  1980
gctatgaat  ataacataa  tgtgtaatg  gcaggatat  agatatggg  tatagatac  2040
cacacacac  cacaagctt  tgaccaccg  tttagacta  cacagctca  atggggtag  2100
aagacccag  agataaata  gaagaaaga  agtaatttg  agggacaca  gacccaacc  2160
tatattttt  aaatataca  ttaattttc  atttgagta  atgtcttaa  ggtcattgc  2220
ctgttaaga  aattttagt  actactgtt  tcttccaga  tgtttgtat  aggtataag  2280
aaatggtgc  ttcattctt  aaattattg  aacaaaggt  aacatttcc  tgttataaa  2340
atatttaca  tttaactaa  gtaaatgct  agctgaatt  attttatcc  cttaaaaaa  2400
atttttttt  aatgacact  gtttattga  cccaactgt  gggaccaga  tgacatttt  2460
aggcttgtc  ttaacctag  ttcctgtat  cagcagaca  ccaaggaga  aggcaaatt  2520
ttaggccgt  taagtccaa  tggttgcta  aaagaaaac  ctgaaactt  gtgtctttt  2580
cttgatttt  tttttttca  agtcccaga  ggtggtgtt  ttggaatct  ttctttcgg  2640
gagaactat  gtgattaag  tacaatctt  tatacacct  cccccccaa  aaaaccatt  2700
acacttttg  agaaaaatg  catatactc  aatacttat  gttgtttag  attatagat  2760
tatatttgg  ttcatcttt  ttttcaatt  aggaaggag  ggggcagat  tgaattcat  2820
gtggcatcc  gcttatatc  gcttggctt  ttcatagtt  gtgacaccc  aactcctgg  2880
atgatatag  gctcccttt  gtgcttgac  ttgtttagc  tgaattgtt  tgagaaata  2940
gagcttttt  atttaaaga  aaattcaag  aagcttgtg  atggcgaag  tctcatttc  3000
ttttctggt  tttgttttc  tcttcgtag  gaaaaaaaa  aaaaaaaaa  gcctataaa  3060
tggctgtta  atattttta  ccagtaaca  tgagatttc  ttagttttt  tttgaatgt  3120
tacctctta  ttagagtat  tggtttcgt  gttctgtag  gtcctacta  aatattcat  3180
tttttacag  gtattgcaa  ttccacatt  catgcaaat  cgattcact  atacctagc  3240
gtttgtgga  tcaaactca  aagtgaacc  ctgctgggg  taagttcct  gtgtcctga  3300
atccccctg  gttttgtgc  gtttacaga  ccgagtggt  aatgcattt  gtagctctt  3360
atacgaagg  ttagagaag  cagaatcaa  aagttcaat  cacaacttt  tgacacacc  3420
cgagtttag  atagaagat  cagagccgc  catccccct  atcgatgac  ctgatgctg  3480
agatgacgc  cctactaaa  gcaactcca  ccctccgcc  tctcctaac  aaaataata  3540
tgccgttga  agcgggatc  3559



<210> 2779
<211> 1258
<212> PRT
<213> Rattus norvegicus
<308> AAA50878
<400> 2779

Met Gly Asp Met Ala Asn Asn Ser Val Ala Tyr Ser Gly Val Lys Asn 
  1               5                  10                  15
Ser Leu Lys Glu Ala Asn His Asp Gly Asp Phe Gly Ile Thr Leu Ala 
             20                  25                  30
Glu Leu Arg Ala Leu Met Glu Leu Arg Ser Thr Asp Ala Leu Arg Lys 
         35                  40                  45
Ile Gln Glu Ser Tyr Gly Asp Val Tyr Gly Ile Cys Thr Lys Leu Lys 
     50                  55                  60
Thr Ser Pro Asn Glu Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Arg 
 65                  70                  75                  80
Arg Glu Ala Val Phe Gly Lys Asn Phe Ile Pro Pro Lys Lys Pro Lys 
                 85                  90                  95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
             100                105                110
Ile Leu Glu Ile Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Gln 
         115                120                125
Pro Pro Glu Gly Asp Asn Ala Leu Cys Gly Glu Val Ser Val Gly Glu 
     130                135                140
Glu Glu Gly Glu Gly Glu Thr Gly Trp Ile Glu Gly Ala Ala Ile Leu 
 145                150                155                160
Leu Ser Val Val Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser 
                 165                170                175
Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln 
             180                185                190
Lys Phe Thr Val Ile Arg Gly Gly Gln Val Ile Gln Ile Pro Val Ala 
         195                200                205
Asp Ile Thr Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu 
     210                215                220
Pro Ala Asp Gly Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu 
 225                230                235                240
Ser Ser Leu Thr Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys 
                 245                250                255
Asp Pro Leu Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg 
             260                265                270
Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe 
         275                280                285
Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Glu Lys 
     290                295                300
Lys Lys Glu Lys Lys Asn Lys Lys Gln Asp Gly Ala Ile Glu Asn Arg 
 305                310                315                320
Asn Lys Ala Lys Ala Gln Asp Gly Ala Ala Met Glu Met Gln Pro Leu 
                 325                330                335
Lys Ser Glu Glu Gly Gly Asp Gly Asp Glu Lys Asp Lys Lys Lys Ala 
             340                345                350
Asn Leu Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys 
         355                360                365
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Leu Met Ser Ala Ile Thr 
     370                375                380
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Asp Thr Phe Trp Val Gln 
 385                390                395                400
Lys Arg Pro Trp Leu Ala Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe 
                 405                410                415
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro 
             420                425                430
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys 
         435                440                445
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu 
     450                455                460
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu 
 465                470                475                480
Thr Met Asn Arg Met Thr Val Val Gln Ala Tyr Ile Asn Glu Lys His 
                 485                490                495
Tyr Lys Lys Val Pro Glu Pro Glu Ala Ile Pro Pro Asn Ile Leu Ser 
             500                505                510
Tyr Leu Val Thr Gly Ile Ser Val Asn Cys Ala Tyr Thr Ser Lys Ile 
         515                520                525
Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro Arg His Val Gly Asn Lys 
     530                535                540
Thr Glu Cys Ala Leu Leu Gly Phe Leu Leu Asp Leu Lys Arg Asp Tyr 
 545                550                555                560
Gln Asp Val Arg Asn Glu Ile Pro Glu Glu Ala Leu Tyr Lys Val Tyr 
                 565                570                575
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Leu Lys Asn Ser 
             580                585                590
Asp Gly Ser Phe Arg Ile Phe Ser Lys Gly Ala Ser Glu Ile Ile Leu 
         595                600                605
Lys Lys Cys Phe Lys Ile Leu Ser Ala Asn Gly Glu Ala Lys Val Phe 
     610                615                620
Arg Pro Arg Asp Arg Asp Asp Ile Val Lys Thr Val Ile Glu Pro Met 
 625                630                635                640
Ala Ser Glu Gly Leu Arg Thr Ile Cys Leu Ala Phe Arg Asp Phe Pro 
                 645                650                655
Ala Gly Glu Pro Glu Pro Glu Trp Asp Asn Glu Asn Asp Val Val Thr 
             660                665                670
Gly Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro 
         675                680                685
Glu Val Pro Glu Ala Ile Lys Lys Cys Gln Arg Ala Gly Ile Thr Val 
     690                695                700
Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Thr 
 705                710                715                720
Lys Cys Gly Ile Leu His Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly 
                 725                730                735
Lys Asp Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln 
             740                745                750
Glu Arg Ile Asp Lys Ile Trp Pro Lys Leu Arg Val Leu Ala Arg Ser 
         755                760                765
Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr 
     770                775                780
Val Ser Glu Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn 
 785                790                795                800
Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile 
                 805                810                815
Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp 
             820                825                830
Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val 
         835                840                845
Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val 
     850                855                860
Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser 
 865                870                875                880
Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr 
                 885                890                895
Leu Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu 
             900                905                910
Leu Arg Lys Pro Tyr Gly Arg Asn Lys Pro Leu Ile Ser Arg Thr Met 
         915                920                925
Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu Val Val Val Phe 
     930                935                940
Thr Leu Leu Phe Ala Gly Glu Lys Phe Phe Asp Ile Asp Ser Gly Arg 
 945                950                955                960
Asn Ala Pro Leu His Ala Pro Pro Ser Glu His Tyr Thr Ile Val Phe 
                 965                970                975
Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys 
             980                985                990
Ile His Gly Glu Arg Asn Val Phe Glu Gly Ile Phe Asn Asn Ala Ile 
         995                1000                1005
Phe Cys Thr Ile Val Leu Gly Thr Phe Val Val Gln Ile Ile Ile Val 
     1010                1015                1020
Gln Phe Gly Gly Lys Pro Phe Ser Cys Ser Glu Leu Ser Ile Glu Gln 
 1025                1030                1035                1040
Trp Leu Trp Ser Ile Phe Leu Gly Met Gly Thr Leu Leu Trp Gly Gln 
                 1045                1050                1055
Leu Ile Ser Thr Ile Pro Thr Ser Arg Leu Lys Phe Leu Lys Glu Ala 
             1060                1065                1070
Gly His Gly Thr Gln Lys Glu Glu Ile Pro Glu Glu Glu Leu Ala Glu 
         1075                1080                1085
Asp Val Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln 
     1090                1095                1100
Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Asp Val 
 1105                1110                1115                1120
Val Asn Ala Phe Gln Ser Gly Gly Ser Ile Gln Gly Ala Leu Arg Arg 
                 1125                1130                1135
Gln Pro Ser Ile Ala Ser Gln His His Asp Val Thr Asn Val Ser Thr 
             1140                1145                1150
Pro Thr His Ile Arg Val Val Asn Ala Phe Arg Ser Ser Leu Tyr Glu 
         1155                1160                1165
Gly Leu Glu Lys Pro Glu Ser Arg Ser Ser Ile His Asn Phe Met Thr 
     1170                1175                1180
His Pro Glu Phe Arg Ile Glu Asp Ser Glu Pro Leu Ile Pro Leu Ile 
 1185                1190                1195                1200
Asp Asp Thr Asp Ala Glu Asp Asp Ala Pro Thr Lys Arg Asn Ser Ser 
                 1205                1210                1215
Pro Pro Pro Ser Pro Asn Lys Asn Asn Asn Ala Val Asp Ser Gly Ile 
             1220                1225                1230
His Leu Thr Ile Glu Met Asn Lys Ser Ala Thr Ser Ser Ser Pro Gly 
         1235                1240                1245
Ser Pro Leu His Ser Leu Glu Thr Ser Leu 
     1250                1255



<210> 2780
<211> 3164
<212> DNA
<213> Homo sapiens
<308> M95542
<400> 2780

taaagactt  ttaacatga  ctgattcac  agtcaatga  ctttcatca  ttttaagat  60
gttgccttg  ataagtatg  cgtcagctg  aagaagatc  ccatatttc  cttgagcaa  120
atctccaac  gtaatgtca  ctacaggta  tcatgtaat  gaaggctct  gaagaatgg  180
agttacagc  gtaggtgta  attctcaaa  tggaattat  tttacctta  ttggagctg  240
aggtgaaga  gaagagaag  aagatgaga  gaaaaagga  aagaaaaat  agaaacaag  300
tggagctat  gagaatcgc  acaaagcaa  agcccagga  ggtgcagcc  tggaaatgc  360
gccattgaa  agtgaagaa  gtggagatg  tgatgaaaa  gataaaaag  aagcaaatt  420
gccaaaaaa  gaaaaatct  ttttacaag  gaaacttac  aaactggct  ttcagattg  480
caaagcagg  ctgttgatg  ctgccatca  agttatcat  ctagtatta  attttgtca  540
tgacacctt  tgggttcag  aaagaccat  gcttgctga  tgcacacca  tttatatac  600
atactttgt  aagttcttc  ttattggag  tacagtttt  gtggtcgca  tgccagaag  660
tcttccact  gcagtcacg  tctcactgg  ttattcagt  aaaaaaatg  tgaaagata  720
taacttagt  aggcatctg  atgcttgtg  aaccatggg  aatgctaca  ctatttgtt  780
agataaaac  ggaactttg  caatgaaca  aatgacagt  gttcaagct  acataaatg  840
aaaacatta  aaaaaggtt  ctgaaccag  agctattcc  ccaaatatt  tgtcctatc  900
tgtaacagg  atttctgtg  attgtgctt  tacatcaaa  atattgcca  cagagaaag  960
gggtggatt  cctcgtcac  ttggtaata  aactgaatg  gccttgttg  gacttcttt  1020
ggatttaaa  cgggattat  aggatgtta  aaatgaaat  ccagaagaa  cactgtaca  1080
agtctacac  ttcaattct  ttaggaagt  catgagtac  gtcctgaaa  attcagatg  1140
aagttatcg  atattcagc  agggtgcat  tgagataat  ctgaaaaag  gtttcaaaa  1200
cttgagtgc  aatggtgag  caaaagtat  cagaccaag  gaccgtgat  atattgtaa  1260
aactgtgat  gaaccgatg  catcagaag  cttgagaac  atatgtctt  cattcagag  1320
ttttccagc  ggagaacca  aaccagagt  ggataatga  aatgatatt  tcaccggcc  1380
tacatgcat  gctgttgtg  ggattgaag  tcctgtgag  cctgaggtg  cagatgcaa  1440
taaaaagtg  cagagggct  gaattactg  gcggatggt  actggtgat  atattaata  1500
tgctcgggc  attgctacc  aatgtggta  tttacatcc  ggggaagat  ttctgtgcc  1560
agaaggtaa  gattttaac  gaagaatac  aaatgaaaa  ggagagatt  agcaagaga  1620
gatagacaa  atttggcca  aacttcgag  acttgcaag  tcatctcct  ctgataagc  1680
tacactggt  aaaggtata  ttgacagca  tgtctcaga  caacgccag  ttgtagctg  1740
aactggtga  ggtacaaat  atggcccag  actaaagaa  gcagatgtt  gatttgcaa  1800
gggtattgc  ggaactgat  tagctaaag  agcatccga  attattctc  cagatgaca  1860
ctttacaag  attgttaaa  cagttatgt  gggacgaaa  gtctatgac  gcatctcaa  1920
attccttca  ttccaactt  ctgttaatg  agtagcagt  attgttgct  ttacgggcg  1980
ctgcattac  caagactca  cgcttaagg  tgtgcagat  ctgtgggta  acctcataa  2040
ggatacact  gcttccctg  ctctggcaa  ggaaccacc  actgagtct  tcttgcttc  2100
gaaacctta  ggtagaaat  agcctctca  ctcacgtac  atgatgaag  atattttgg  2160
tcatgcatt  tatcaactt  tagtagtct  tacactctt  tttgctgga  aaaagtttt  2220
tgacattga  agtggaaga  atgctcctt  gcatgctcc  ccttcagaa  attatacta  2280
tgtttttaa  acctttgtg  tgatgcaac  tttcaacga  ataaatgcc  ggaaaattc  2340
tggtgaaag  aatgtattc  aaggaatct  taacaatgc  atcttctgc  caattgttt  2400
aggcacttt  gtggtacag  taataattg  gcagtttgg  ggaaaacct  tcagttgtt  2460
agaactttc  atagaacag  ggctatggt  aatattcct  ggaatggga  cattactct  2520
gggccagct  atttcaaca  ttccaacta  ccgtttaaa  ttcctcaaa  aagctggtc  2580
tggaacaca  aaggaagaa  tacctgagg  ggaattagc  gaggatgtt  aagagattg  2640
tcacgctga  agggagttg  ggcgtggcc  aatcttgtg  tttagaggt  tgaacagaa  2700
ccaaacaca  attcgagtg  tgaatgcat  tcgtagttc  ttatatgaa  ggttagaaa  2760
accggaatc  agaagttcg  ttcacaact  tatgacaca  cctgagttt  ggatagaag  2820
ttcagagcc  catatcccc  ttattgatg  cactgatgc  gaagatgat  ctcctacaa  2880
acgtaactc  agtcctcca  cctctccca  caaaaataa  aatgctgtt  acagtggaa  2940
tcaccttac  atagaaatg  acaagtctg  tacctcttc  tccccagga  gcccactac  3000
tagtttgga  acatcactc  gattgtaag  tgaatgtta  cacactagc  gcattgtaa  3060
gaaacaaat  gaaactggg  cttttcaca  attgtgatg  acaagctag  attcttgtc  3120
ttggacttc  acagaagac  cacttgtac  aatgtagat  tatt  3164



<210> 2781
<211> 1258
<212> PRT
<213> Homo sapiens
<308> P20020
<400> 2781

Met Gly Asp Met Ala Asn Asn Ser Val Ala Tyr Ser Gly Val Lys Asn 
  1               5                  10                  15
Ser Leu Lys Glu Ala Asn His Asp Gly Asp Phe Gly Ile Thr Leu Ala 
             20                  25                  30
Glu Leu Arg Ala Leu Met Glu Leu Arg Ser Thr Asp Ala Leu Arg Lys 
         35                  40                  45
Ile Gln Glu Ser Tyr Gly Asp Val Tyr Gly Ile Cys Thr Lys Leu Lys 
     50                  55                  60
Thr Ser Pro Asn Glu Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Arg 
 65                  70                  75                  80
Arg Glu Ala Val Phe Gly Lys Asn Phe Ile Pro Pro Lys Lys Pro Lys 
                 85                  90                  95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
             100                105                110
Ile Leu Glu Ile Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Gln 
         115                120                125
Pro Pro Glu Gly Asp Asn Ala Leu Cys Gly Glu Val Ser Val Gly Glu 
     130                135                140
Glu Glu Gly Glu Gly Glu Thr Gly Trp Ile Glu Gly Ala Ala Ile Leu 
 145                150                155                160
Leu Ser Val Val Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser 
                 165                170                175
Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln 
             180                185                190
Lys Phe Thr Val Ile Arg Gly Gly Gln Val Ile Gln Ile Pro Val Ala 
         195                200                205
Asp Ile Thr Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu 
     210                215                220
Pro Ala Asp Gly Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu 
 225                230                235                240
Ser Ser Leu Thr Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys 
                 245                250                255
Asp Pro Leu Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg 
             260                265                270
Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe 
         275                280                285
Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Glu Lys 
     290                295                300
Lys Lys Glu Lys Lys Asn Lys Lys Gln Asp Gly Ala Ile Glu Asn Arg 
 305                310                315                320
Asn Lys Ala Lys Ala Gln Asp Gly Ala Ala Met Glu Met Gln Pro Leu 
                 325                330                335
Lys Ser Glu Glu Gly Gly Asp Gly Asp Glu Lys Asp Lys Lys Lys Ala 
             340                345                350
Asn Leu Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys 
         355                360                365
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Leu Met Ser Ala Ile Thr 
     370                375                380
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Asp Thr Phe Trp Val Gln 
 385                390                395                400
Lys Arg Pro Trp Leu Ala Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe 
                 405                410                415
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro 
             420                425                430
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys 
         435                440                445
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu 
     450                455                460
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu 
 465                470                475                480
Thr Met Asn Arg Met Thr Val Val Gln Ala Tyr Ile Asn Glu Lys His 
                 485                490                495
Tyr Lys Lys Val Pro Glu Pro Glu Ala Ile Pro Pro Asn Ile Leu Ser 
             500                505                510
Tyr Leu Val Thr Gly Ile Ser Val Asn Cys Ala Tyr Thr Ser Lys Ile 
         515                520                525
Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro Arg His Val Gly Asn Lys 
     530                535                540
Thr Glu Cys Ala Leu Leu Gly Leu Leu Leu Asp Leu Lys Arg Asp Tyr 
 545                550                555                560
Gln Asp Val Arg Asn Glu Ile Pro Glu Glu Ala Leu Tyr Lys Val Tyr 
                 565                570                575
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Leu Lys Asn Ser 
             580                585                590
Asp Gly Ser Tyr Arg Ile Phe Ser Lys Gly Ala Ser Glu Ile Ile Leu 
         595                600                605
Lys Lys Cys Phe Lys Ile Leu Ser Ala Asn Gly Glu Ala Lys Val Phe 
     610                615                620
Arg Pro Arg Asp Arg Asp Asp Ile Val Lys Thr Val Ile Glu Pro Met 
 625                630                635                640
Ala Ser Glu Gly Leu Arg Thr Ile Cys Leu Ala Phe Arg Asp Phe Pro 
                 645                650                655
Ala Gly Glu Pro Glu Pro Glu Trp Asp Asn Glu Asn Asp Ile Val Thr 
             660                665                670
Gly Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro 
         675                680                685
Glu Val Pro Asp Ala Ile Lys Lys Cys Gln Arg Ala Gly Ile Thr Val 
     690                695                700
Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Thr 
 705                710                715                720
Lys Cys Gly Ile Leu His Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly 
                 725                730                735
Lys Asp Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln 
             740                745                750
Glu Arg Ile Asp Lys Ile Trp Pro Lys Leu Arg Val Leu Ala Arg Ser 
         755                760                765
Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr 
     770                775                780
Val Ser Asp Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn 
 785                790                795                800
Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile 
                 805                810                815
Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp 
             820                825                830
Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val 
         835                840                845
Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val 
     850                855                860
Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser 
 865                870                875                880
Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr 
                 885                890                895
Leu Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu 
             900                905                910
Leu Arg Lys Pro Tyr Gly Arg Asn Lys Pro Leu Ile Ser Arg Thr Met 
         915                920                925
Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu Val Val Val Phe 
     930                935                940
Thr Leu Leu Phe Ala Gly Glu Lys Phe Phe Asp Ile Asp Ser Gly Arg 
 945                950                955                960
Asn Ala Pro Leu His Ala Pro Pro Ser Glu His Tyr Thr Ile Val Phe 
                 965                970                975
Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys 
             980                985                990
Ile His Gly Glu Arg Asn Val Phe Glu Gly Ile Phe Asn Asn Ala Ile 
         995                1000                1005
Phe Cys Thr Ile Val Leu Gly Thr Phe Val Val Gln Ile Ile Ile Val 
     1010                1015                1020
Gln Phe Gly Gly Lys Pro Phe Ser Cys Ser Glu Leu Ser Ile Glu Gln 
 1025                1030                1035                1040
Trp Leu Trp Ser Ile Phe Leu Gly Met Gly Thr Leu Leu Trp Gly Gln 
                 1045                1050                1055
Leu Ile Ser Thr Ile Pro Thr Ser Arg Leu Lys Phe Leu Lys Glu Ala 
             1060                1065                1070
Gly His Gly Thr Gln Lys Glu Glu Ile Pro Glu Glu Glu Leu Ala Glu 
         1075                1080                1085
Asp Val Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln 
     1090                1095                1100
Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Asp Val 
 1105                1110                1115                1120
Val Asn Ala Phe Gln Ser Gly Ser Ser Ile Gln Gly Ala Leu Arg Arg 
                 1125                1130                1135
Gln Pro Ser Ile Ala Ser Gln His His Asp Val Thr Asn Ile Ser Thr 
             1140                1145                1150
Pro Thr His Ile Arg Val Val Asn Ala Phe Arg Ser Ser Leu Tyr Glu 
         1155                1160                1165
Gly Leu Glu Lys Pro Glu Ser Arg Ser Ser Ile His Asn Phe Met Thr 
     1170                1175                1180
His Pro Glu Phe Arg Ile Glu Asp Ser Glu Pro His Ile Pro Leu Ile 
 1185                1190                1195                1200
Asp Asp Thr Asp Ala Glu Asp Asp Ala Pro Thr Lys Arg Asn Ser Ser 
                 1205                1210                1215
Pro Pro Pro Ser Pro Asn Lys Asn Asn Asn Ala Val Asp Ser Gly Ile 
             1220                1225                1230
His Leu Thr Ile Glu Met Asn Lys Ser Ala Thr Ser Ser Ser Pro Gly 
         1235                1240                1245
Ser Pro Leu His Ser Leu Glu Thr Ser Leu 
     1250                1255



<210> 2782
<211> 1912
<212> DNA
<213> Rattus norvegicus
<308> L04760
<400> 2782

cgggggacg  ctgtggtga  ggttctgga  tgtggtgtt  gtgaagatg  cttctctct  60
caaggagat  aagttcctc  ccttctcct  tgtggccac  cagtctgtc  tgactgtct  120
tctcgcttg  ctctgcatg  aagagcaat  cgttgccca  ttgatcgac  agtgacaga  180
ctaggagat  caggtgtct  gggtttgaa  aaaaatttt  ctttactgg  gcttttaga  240
cgtttgcaa  atggacata  tggtcagta  ggagctgca  aagaagccc  tgggatatc  300
ggagagagt  tcattcgct  tgatgaaga  gaagctcac  ttgcatctg  gtactgcac  360
gtgtgtgcg  ctcacttgt  ctcagagtg  tctcaagtc  ctcattcta  aaagactct  420
gccaagcat  ggcgagtgc  tctagctga  aaacctcat  agaagacca  gtgctgtca  480
caccaggta  atgccattg  gtttgtttg  ttggaagaa  cttgtcaaa  tagtcctct  540
atgtgctgt  tctgcaaag  atatggaaa  caccagggt  acaagcact  agtactgga  600
ccagaagct  accagatcc  agcgtcaat  ttagacatg  ctcactgca  acgaacctt  660
actgaggag  tctcagatt  ttccagaaa  ttagttggg  ttgttcagc  cattgaagg  720
ggagaacaa  tagtggaag  tggaattgg  atggctcac  cggaacacg  cccaggtac  780
gcagagaat  cacgatcat  tgtcagagc  tatttttct  atttgcatg  aactctttg  840
cgtcaagaa  aaatggctc  cagtgttgt  gatgcccat  ttcgagaaa  actgatttg  900
cttaggcag  aacaagagg  tatgactat  ctcttgtcc  aggtttcaa  agcctgtct  960
cattgtgaa  agactttgc  gcaggatga  tgcagagtt  tcttggcaa  acaagaaat  1020
acaagatta  tagaaacac  gcagaaaca  cagcagcag  ttacagaag  tgcagatca  1080
attcagttg  atgccagta  tccagtcac  tttacaaag  acaacagag  ttatattgg  1140
cccaaaatg  aaatacgag  agtcacatt  ggattagat  gtgctggaa  aactactat  1200
ttgttcaag  taaaacaag  tgaatttat  cagcctatt  caacaattg  ttttaatgt  1260
gaaactgtg  aatacaaaa  tctaaaatt  accatttgg  atgtgggtg  aaaacacaa  1320
ttaagacca  tgtggaaac  ttattacct  aatacacaa  ctgttgtat  tgttgttga  1380
agcagtcac  gagacagaa  tagtgaagc  cacagtgaa  ttgcgaagt  gttaacaga  1440
aaagaactt  gagatgcct  actcttgat  tttgctaac  aacaggatg  cgctggggc  1500
ctttcggtt  aagaaatca  cgaacttct  agtctccat  aattatgct  cggaaggag  1560
tggtatatt  agggctgtg  tgctcgaag  ggtatgggg  tctacgaag  gttggactg  1620
ctgtcccgg  aacttgtgg  tgccggagt  ttggatgtt  cttgattct  ttgcagcag  1680
tgtttcgag  ttatggtta  aaagttact  tgcatgtaa  aaaaaaaaa  aaaaatgca  1740
tctaagaaa  tctacatct  aagtatgat  atttagtat  tgtacgtat  aatcctgga  1800
tgagaaatg  accattgct  ttaaaaatt  ttctgtggc  aatttaagt  atcctgtta  1860
attggttaa  tagttttgc  ttgtttttt  ttggatata  acttttaaa  gg  1912



<210> 2783
<211> 554
<212> PRT
<213> Rattus norvegicus
<308> P36407
<400> 2783

Arg Gly Thr Ala Val Val Lys Val Leu Glu Cys Gly Val Cys Glu Asp 
  1               5                  10                  15
Val Phe Ser Leu Gln Gly Asp Lys Val Pro Arg Leu Leu Leu Cys Gly 
             20                  25                  30
His Thr Val Cys His Asp Cys Leu Ser Arg Leu Pro Leu His Gly Arg 
         35                  40                  45
Ala Ile Arg Cys Pro Phe Asp Arg Gln Val Thr Asp Leu Gly Asp Ser 
     50                  55                  60
Gly Val Trp Gly Leu Lys Lys Asn Phe Ala Leu Leu Glu Leu Leu Glu 
 65                  70                  75                  80
Arg Leu Gln Asn Gly His Ile Gly Gln Tyr Gly Ala Ala Glu Glu Ala 
                 85                  90                  95
Leu Gly Ile Ser Gly Glu Ser Ile Ile Arg Cys Asp Glu Asp Glu Ala 
             100                105                110
His Val Ala Ser Val Tyr Cys Thr Val Cys Ala Thr His Leu Cys Ser 
         115                120                125
Glu Cys Ser Gln Val Thr His Ser Thr Lys Thr Leu Ala Lys His Arg 
     130                135                140
Arg Val Pro Leu Ala Asp Lys Pro His Glu Lys Thr Met Cys Cys Gln 
 145                150                155                160
His Gln Val His Ala Ile Glu Phe Val Cys Leu Glu Glu Ala Cys Gln 
                 165                170                175
Thr Ser Pro Leu Met Cys Cys Val Cys Lys Glu Tyr Gly Lys His Gln 
             180                185                190
Gly His Lys His Ser Val Leu Glu Pro Glu Ala Asn Gln Ile Arg Ala 
         195                200                205
Ser Ile Leu Asp Met Ala His Cys Ile Arg Thr Phe Thr Glu Glu Ile 
     210                215                220
Ser Asp Tyr Ser Arg Lys Leu Val Gly Ile Val Gln His Ile Glu Gly 
 225                230                235                240
Gly Glu Gln Ile Val Glu Asp Gly Ile Gly Met Ala His Thr Glu His 
                 245                250                255
Val Pro Gly Thr Ala Glu Asn Ala Arg Ser Cys Val Arg Ala Tyr Phe 
             260                265                270
Ser Asp Leu His Glu Thr Leu Cys Arg Gln Glu Glu Met Ala Leu Ser 
         275                280                285
Val Val Asp Ala His Val Arg Glu Lys Leu Ile Trp Leu Arg Gln Gln 
     290                295                300
Gln Glu Asp Met Thr Ile Leu Leu Ser Gln Val Ser Thr Ala Cys Leu 
 305                310                315                320
His Cys Glu Lys Thr Leu Gln Gln Asp Asp Cys Arg Val Val Leu Ala 
                 325                330                335
Lys Gln Glu Ile Thr Arg Leu Leu Glu Thr Leu Gln Lys Gln Gln Gln 
             340                345                350
Gln Phe Thr Glu Val Ala Asp His Ile Gln Leu Asp Ala Ser Ile Pro 
         355                360                365
Val Thr Phe Thr Lys Asp Asn Arg Val Tyr Ile Gly Pro Lys Met Glu 
     370                375                380
Ile Arg Val Val Thr Leu Gly Leu Asp Gly Ala Gly Lys Thr Thr Ile 
 385                390                395                400
Leu Phe Lys Leu Lys Gln Asp Glu Phe Met Gln Pro Ile Pro Thr Ile 
                 405                410                415
Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Leu Lys Phe Thr Ile 
             420                425                430
Trp Asp Val Gly Glu Lys His Lys Leu Arg Pro Leu Trp Lys His Tyr 
         435                440                445
Tyr Leu Asn Thr Gln Ala Val Val Phe Val Val Asp Ser Ser His Arg 
     450                455                460
Asp Arg Ile Ser Glu Ala His Ser Glu Leu Ala Lys Leu Leu Thr Glu 
 465                470                475                480
Lys Glu Leu Arg Asp Ala Leu Leu Leu Ile Phe Ala Asn Lys Gln Asp 
                 485                490                495
Val Ala Gly Ala Leu Ser Val Glu Glu Ile Thr Glu Leu Leu Ser Leu 
             500                505                510
His Lys Leu Cys Cys Gly Arg Ser Trp Tyr Ile Gln Gly Cys Asp Ala 
         515                520                525
Arg Ser Gly Met Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Arg Gln 
     530                535                540
Leu Val Ala Ala Gly Val Leu Asp Val Ala 
 545                550



<210> 2784
<211> 1822
<212> DNA
<213> Homo sapiens
<308> AF230399
<400> 2784

ctgtggcgc  tcccctgcg  ggatggcta  cctggttgt  aacaagctc  gagcgggag  60
agacagtgg  cggcagggc  gccggggga  agctgtagt  aaggtgcta  agtgtggag  120
ttgtgaaga  gtcttttct  tgcaaggag  caaagttcc  cgtcttttg  tttgtggcc  180
taccgtctg  catgactgt  tcactcgcc  acctcttca  ggaagagca  tccgttgcc  240
atttgatcg  caagtaaca  acctaggtg  ttcaggtgt  tggggattg  aaaaaaatt  300
tgctttatt  gagcttttg  aacgactgc  gaatgggcc  attggtcag  atggagctg  360
agaagaatc  attgggata  ctggagaga  catcattcg  tgtgatgaa  atgaagctc  420
ccttgcctc  gtatattgc  ctgtgtgtg  aactcattt  tgctctgag  gttctcaag  480
tactcattc  acaaagaca  tagcaaagc  caggcgagt  cctctagct  ataaacctc  540
tgagaaaac  atgtgctct  agcaccagg  gcatgccat  gagtttgtt  gcttggaag  600
aggttgtca  actagccca  tcatgtgct  tgtctgcaa  gaatatgga  aacaccagg  660
tcacaagca  tcagtattg  aaccagaag  taatcagat  cgagcatca  ttttagata  720
ggctcactg  atacggacc  tcacagagg  aatctcaga  tattccaga  aattagttg  780
aattgtgca  cacattgaa  gaggagaac  aatcgtgga  gatggaatt  gaatggctc  840
cacagaaca  gtaccaggg  ctgcagaga  tgcccggtc  tgtattcga  cttattttt  900
tgatctaca  gaaactctg  gtcgtcaag  agaaatggc  ctaagtgtt  ttgatgctc  960
tgttcgtga  aaattgatt  ggctcaggc  gcaacaaga  gatatgact  ttttgttgt  1020
agaggtttc  gcagcctgc  tccactgtg  aaagacttt  cagcaggat  attgtagag  1080
tgtcttggc  aaacaggaa  ttacaaggt  actggaaac  ttgcagaaa  agcagcagc  1140
gtttacaga  gttgcagat  acattcagt  ggatgccag  atccctgtc  cttttacaa  1200
ggataatcg  gttcacatt  gaccaaaaa  ggaaattcg  gtcgttacg  taggattgg  1260
tggtgctgg  aaaactact  tcttgttta  gttaaaaca  gatgaattc  tgcagccca  1320
tccaacaat  ggttttaac  tggaaactg  agaatataa  aatctaaaa  tcactattt  1380
ggatgtagg  ggaaaacac  aattaagac  attgtggaa  cattattac  tcaatactc  1440
agctgttgt  tttgttgta  atagcagtc  tagagacag  attagtgaa  cacacagcg  1500
acttgcaaa  ttgttaacg  aaaaagaac  ccgagatgc  ctgctcctg  tttttgcta  1560
caaacagga  gttgctgga  cactgtcag  agaagaaat  actgaacta  tcagtctcc  1620
taaattatg  tgtggccgt  gctgttttt  agataatat  tgaccaata  actgggaaa  1680
aggtagtca  agagaaagg  taaaaggtc  tgctgttac  ggtgtagtt  gtgtgcata  1740
ataatactt  cgaattaaa  tatttaata  ttgactgat  tcaataact  tgaaaataa  1800
aaggtgttg  attgcttgt  ag  1822



<210> 2785
<211> 574
<212> PRT
<213> Homo sapiens
<308> P36406
<400> 2785

Met Ala Thr Leu Val Val Asn Lys Leu Gly Ala Gly Val Asp Ser Gly 
  1               5                  10                  15
Arg Gln Gly Ser Arg Gly Thr Ala Val Val Lys Val Leu Glu Cys Gly 
             20                  25                  30
Val Cys Glu Asp Val Phe Ser Leu Gln Gly Asp Lys Val Pro Arg Leu 
         35                  40                  45
Leu Leu Cys Gly His Thr Val Cys His Asp Cys Leu Thr Arg Leu Pro 
     50                  55                  60
Leu His Gly Arg Ala Ile Arg Cys Pro Phe Asp Arg Gln Val Thr Asp 
 65                  70                  75                  80
Leu Gly Asp Ser Gly Val Trp Gly Leu Lys Lys Asn Phe Ala Leu Leu 
                 85                  90                  95
Glu Leu Leu Glu Arg Leu Gln Asn Gly Pro Ile Gly Gln Tyr Gly Ala 
             100                105                110
Ala Glu Glu Ser Ile Gly Ile Ser Gly Glu Ser Ile Ile Arg Cys Asp 
         115                120                125
Glu Asp Glu Ala His Leu Ala Ser Val Tyr Cys Thr Val Cys Ala Thr 
     130                135                140
His Leu Cys Ser Glu Cys Ser Gln Val Thr His Ser Thr Lys Thr Leu 
 145                150                155                160
Ala Lys His Arg Arg Val Pro Leu Ala Asp Lys Pro His Glu Lys Thr 
                 165                170                175
Met Cys Ser Gln His Gln Val His Ala Ile Glu Phe Val Cys Leu Glu 
             180                185                190
Glu Gly Cys Gln Thr Ser Pro Leu Met Cys Cys Val Cys Lys Glu Tyr 
         195                200                205
Gly Lys His Gln Gly His Lys His Ser Val Leu Glu Pro Glu Ala Asn 
     210                215                220
Gln Ile Arg Ala Ser Ile Leu Asp Met Ala His Cys Ile Arg Thr Phe 
 225                230                235                240
Thr Glu Glu Ile Ser Asp Tyr Ser Arg Lys Leu Val Gly Ile Val Gln 
                 245                250                255
His Ile Glu Gly Gly Glu Gln Ile Val Glu Asp Gly Ile Gly Met Ala 
             260                265                270
His Thr Glu His Val Pro Gly Thr Ala Glu Asn Ala Arg Ser Cys Ile 
         275                280                285
Arg Ala Tyr Phe Tyr Asp Leu His Glu Thr Leu Cys Arg Gln Glu Glu 
     290                295                300
Met Ala Leu Ser Val Val Asp Ala His Val Arg Glu Lys Leu Ile Trp 
 305                310                315                320
Leu Arg Gln Gln Gln Glu Asp Met Thr Ile Leu Leu Ser Glu Val Ser 
                 325                330                335
Ala Ala Cys Leu His Cys Glu Lys Thr Leu Gln Gln Asp Asp Cys Arg 
             340                345                350
Val Val Leu Ala Lys Gln Glu Ile Thr Arg Leu Leu Glu Thr Leu Gln 
         355                360                365
Lys Gln Gln Gln Gln Phe Thr Glu Val Ala Asp His Ile Gln Leu Asp 
     370                375                380
Ala Ser Ile Pro Val Thr Phe Thr Lys Asp Asn Arg Val His Ile Gly 
 385                390                395                400
Pro Lys Met Glu Ile Arg Val Val Thr Leu Gly Leu Asp Gly Ala Gly 
                 405                410                415
Lys Thr Thr Ile Leu Phe Lys Leu Lys Gln Asp Glu Phe Met Gln Pro 
             420                425                430
Ile Pro Thr Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Leu 
         435                440                445
Lys Phe Thr Ile Trp Asp Val Gly Gly Lys His Lys Leu Arg Pro Leu 
     450                455                460
Trp Lys His Tyr Tyr Leu Asn Thr Gln Ala Val Val Phe Val Val Asp 
 465                470                475                480
Ser Ser His Arg Asp Arg Ile Ser Glu Ala His Ser Glu Leu Ala Lys 
                 485                490                495
Leu Leu Thr Glu Lys Glu Leu Arg Asp Ala Leu Leu Leu Ile Phe Ala 
             500                505                510
Asn Lys Gln Asp Val Ala Gly Ala Leu Ser Val Glu Glu Ile Thr Glu 
         515                520                525
Leu Leu Ser Leu His Lys Leu Cys Cys Gly Arg Ser Trp Tyr Ile Gln 
     530                535                540
Gly Cys Asp Ala Arg Ser Gly Met Gly Leu Tyr Glu Gly Leu Asp Trp 
 545                550                555                560
Leu Ser Arg Gln Leu Val Ala Ala Gly Val Leu Asp Val Ala 
                 565                570



<210> 2786
<211> 1912
<212> DNA
<213> Rattus norvegicus
<308> L04760
<400> 2786

cgggggacg  ctgtggtga  ggttctgga  tgtggtgtt  gtgaagatg  cttctctct  60
caaggagat  aagttcctc  ccttctcct  tgtggccac  cagtctgtc  tgactgtct  120
tctcgcttg  ctctgcatg  aagagcaat  cgttgccca  ttgatcgac  agtgacaga  180
ctaggagat  caggtgtct  gggtttgaa  aaaaatttt  ctttactgg  gcttttaga  240
cgtttgcaa  atggacata  tggtcagta  ggagctgca  aagaagccc  tgggatatc  300
ggagagagt  tcattcgct  tgatgaaga  gaagctcac  ttgcatctg  gtactgcac  360
gtgtgtgcg  ctcacttgt  ctcagagtg  tctcaagtc  ctcattcta  aaagactct  420
gccaagcat  ggcgagtgc  tctagctga  aaacctcat  agaagacca  gtgctgtca  480
caccaggta  atgccattg  gtttgtttg  ttggaagaa  cttgtcaaa  tagtcctct  540
atgtgctgt  tctgcaaag  atatggaaa  caccagggt  acaagcact  agtactgga  600
ccagaagct  accagatcc  agcgtcaat  ttagacatg  ctcactgca  acgaacctt  660
actgaggag  tctcagatt  ttccagaaa  ttagttggg  ttgttcagc  cattgaagg  720
ggagaacaa  tagtggaag  tggaattgg  atggctcac  cggaacacg  cccaggtac  780
gcagagaat  cacgatcat  tgtcagagc  tatttttct  atttgcatg  aactctttg  840
cgtcaagaa  aaatggctc  cagtgttgt  gatgcccat  ttcgagaaa  actgatttg  900
cttaggcag  aacaagagg  tatgactat  ctcttgtcc  aggtttcaa  agcctgtct  960
cattgtgaa  agactttgc  gcaggatga  tgcagagtt  tcttggcaa  acaagaaat  1020
acaagatta  tagaaacac  gcagaaaca  cagcagcag  ttacagaag  tgcagatca  1080
attcagttg  atgccagta  tccagtcac  tttacaaag  acaacagag  ttatattgg  1140
cccaaaatg  aaatacgag  agtcacatt  ggattagat  gtgctggaa  aactactat  1200
ttgttcaag  taaaacaag  tgaatttat  cagcctatt  caacaattg  ttttaatgt  1260
gaaactgtg  aatacaaaa  tctaaaatt  accatttgg  atgtgggtg  aaaacacaa  1320
ttaagacca  tgtggaaac  ttattacct  aatacacaa  ctgttgtat  tgttgttga  1380
agcagtcac  gagacagaa  tagtgaagc  cacagtgaa  ttgcgaagt  gttaacaga  1440
aaagaactt  gagatgcct  actcttgat  tttgctaac  aacaggatg  cgctggggc  1500
ctttcggtt  aagaaatca  cgaacttct  agtctccat  aattatgct  cggaaggag  1560
tggtatatt  agggctgtg  tgctcgaag  ggtatgggg  tctacgaag  gttggactg  1620
ctgtcccgg  aacttgtgg  tgccggagt  ttggatgtt  cttgattct  ttgcagcag  1680
tgtttcgag  ttatggtta  aaagttact  tgcatgtaa  aaaaaaaaa  aaaaatgca  1740
tctaagaaa  tctacatct  aagtatgat  atttagtat  tgtacgtat  aatcctgga  1800
tgagaaatg  accattgct  ttaaaaatt  ttctgtggc  aatttaagt  atcctgtta  1860
attggttaa  tagttttgc  ttgtttttt  ttggatata  acttttaaa  gg  1912



<210> 2787
<211> 554
<212> PRT
<213> Rattus norvegicus
<308> P36407
<400> 2787

Arg Gly Thr Ala Val Val Lys Val Leu Glu Cys Gly Val Cys Glu Asp 
  1               5                  10                  15
Val Phe Ser Leu Gln Gly Asp Lys Val Pro Arg Leu Leu Leu Cys Gly 
             20                  25                  30
His Thr Val Cys His Asp Cys Leu Ser Arg Leu Pro Leu His Gly Arg 
         35                  40                  45
Ala Ile Arg Cys Pro Phe Asp Arg Gln Val Thr Asp Leu Gly Asp Ser 
     50                  55                  60
Gly Val Trp Gly Leu Lys Lys Asn Phe Ala Leu Leu Glu Leu Leu Glu 
 65                  70                  75                  80
Arg Leu Gln Asn Gly His Ile Gly Gln Tyr Gly Ala Ala Glu Glu Ala 
                 85                  90                  95
Leu Gly Ile Ser Gly Glu Ser Ile Ile Arg Cys Asp Glu Asp Glu Ala 
             100                105                110
His Val Ala Ser Val Tyr Cys Thr Val Cys Ala Thr His Leu Cys Ser 
         115                120                125
Glu Cys Ser Gln Val Thr His Ser Thr Lys Thr Leu Ala Lys His Arg 
     130                135                140
Arg Val Pro Leu Ala Asp Lys Pro His Glu Lys Thr Met Cys Cys Gln 
 145                150                155                160
His Gln Val His Ala Ile Glu Phe Val Cys Leu Glu Glu Ala Cys Gln 
                 165                170                175
Thr Ser Pro Leu Met Cys Cys Val Cys Lys Glu Tyr Gly Lys His Gln 
             180                185                190
Gly His Lys His Ser Val Leu Glu Pro Glu Ala Asn Gln Ile Arg Ala 
         195                200                205
Ser Ile Leu Asp Met Ala His Cys Ile Arg Thr Phe Thr Glu Glu Ile 
     210                215                220
Ser Asp Tyr Ser Arg Lys Leu Val Gly Ile Val Gln His Ile Glu Gly 
 225                230                235                240
Gly Glu Gln Ile Val Glu Asp Gly Ile Gly Met Ala His Thr Glu His 
                 245                250                255
Val Pro Gly Thr Ala Glu Asn Ala Arg Ser Cys Val Arg Ala Tyr Phe 
             260                265                270
Ser Asp Leu His Glu Thr Leu Cys Arg Gln Glu Glu Met Ala Leu Ser 
         275                280                285
Val Val Asp Ala His Val Arg Glu Lys Leu Ile Trp Leu Arg Gln Gln 
     290                295                300
Gln Glu Asp Met Thr Ile Leu Leu Ser Gln Val Ser Thr Ala Cys Leu 
 305                310                315                320
His Cys Glu Lys Thr Leu Gln Gln Asp Asp Cys Arg Val Val Leu Ala 
                 325                330                335
Lys Gln Glu Ile Thr Arg Leu Leu Glu Thr Leu Gln Lys Gln Gln Gln 
             340                345                350
Gln Phe Thr Glu Val Ala Asp His Ile Gln Leu Asp Ala Ser Ile Pro 
         355                360                365
Val Thr Phe Thr Lys Asp Asn Arg Val Tyr Ile Gly Pro Lys Met Glu 
     370                375                380
Ile Arg Val Val Thr Leu Gly Leu Asp Gly Ala Gly Lys Thr Thr Ile 
 385                390                395                400
Leu Phe Lys Leu Lys Gln Asp Glu Phe Met Gln Pro Ile Pro Thr Ile 
                 405                410                415
Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Leu Lys Phe Thr Ile 
             420                425                430
Trp Asp Val Gly Glu Lys His Lys Leu Arg Pro Leu Trp Lys His Tyr 
         435                440                445
Tyr Leu Asn Thr Gln Ala Val Val Phe Val Val Asp Ser Ser His Arg 
     450                455                460
Asp Arg Ile Ser Glu Ala His Ser Glu Leu Ala Lys Leu Leu Thr Glu 
 465                470                475                480
Lys Glu Leu Arg Asp Ala Leu Leu Leu Ile Phe Ala Asn Lys Gln Asp 
                 485                490                495
Val Ala Gly Ala Leu Ser Val Glu Glu Ile Thr Glu Leu Leu Ser Leu 
             500                505                510
His Lys Leu Cys Cys Gly Arg Ser Trp Tyr Ile Gln Gly Cys Asp Ala 
         515                520                525
Arg Ser Gly Met Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Arg Gln 
     530                535                540
Leu Val Ala Ala Gly Val Leu Asp Val Ala 
 545                550



<210> 2788
<211> 1822
<212> DNA
<213> Homo sapiens
<308> AF230399
<400> 2788

ctgtggcgc  tcccctgcg  ggatggcta  cctggttgt  aacaagctc  gagcgggag  60
agacagtgg  cggcagggc  gccggggga  agctgtagt  aaggtgcta  agtgtggag  120
ttgtgaaga  gtcttttct  tgcaaggag  caaagttcc  cgtcttttg  tttgtggcc  180
taccgtctg  catgactgt  tcactcgcc  acctcttca  ggaagagca  tccgttgcc  240
atttgatcg  caagtaaca  acctaggtg  ttcaggtgt  tggggattg  aaaaaaatt  300
tgctttatt  gagcttttg  aacgactgc  gaatgggcc  attggtcag  atggagctg  360
agaagaatc  attgggata  ctggagaga  catcattcg  tgtgatgaa  atgaagctc  420
ccttgcctc  gtatattgc  ctgtgtgtg  aactcattt  tgctctgag  gttctcaag  480
tactcattc  acaaagaca  tagcaaagc  caggcgagt  cctctagct  ataaacctc  540
tgagaaaac  atgtgctct  agcaccagg  gcatgccat  gagtttgtt  gcttggaag  600
aggttgtca  actagccca  tcatgtgct  tgtctgcaa  gaatatgga  aacaccagg  660
tcacaagca  tcagtattg  aaccagaag  taatcagat  cgagcatca  ttttagata  720
ggctcactg  atacggacc  tcacagagg  aatctcaga  tattccaga  aattagttg  780
aattgtgca  cacattgaa  gaggagaac  aatcgtgga  gatggaatt  gaatggctc  840
cacagaaca  gtaccaggg  ctgcagaga  tgcccggtc  tgtattcga  cttattttt  900
tgatctaca  gaaactctg  gtcgtcaag  agaaatggc  ctaagtgtt  ttgatgctc  960
tgttcgtga  aaattgatt  ggctcaggc  gcaacaaga  gatatgact  ttttgttgt  1020
agaggtttc  gcagcctgc  tccactgtg  aaagacttt  cagcaggat  attgtagag  1080
tgtcttggc  aaacaggaa  ttacaaggt  actggaaac  ttgcagaaa  agcagcagc  1140
gtttacaga  gttgcagat  acattcagt  ggatgccag  atccctgtc  cttttacaa  1200
ggataatcg  gttcacatt  gaccaaaaa  ggaaattcg  gtcgttacg  taggattgg  1260
tggtgctgg  aaaactact  tcttgttta  gttaaaaca  gatgaattc  tgcagccca  1320
tccaacaat  ggttttaac  tggaaactg  agaatataa  aatctaaaa  tcactattt  1380
ggatgtagg  ggaaaacac  aattaagac  attgtggaa  cattattac  tcaatactc  1440
agctgttgt  tttgttgta  atagcagtc  tagagacag  attagtgaa  cacacagcg  1500
acttgcaaa  ttgttaacg  aaaaagaac  ccgagatgc  ctgctcctg  tttttgcta  1560
caaacagga  gttgctgga  cactgtcag  agaagaaat  actgaacta  tcagtctcc  1620
taaattatg  tgtggccgt  gctgttttt  agataatat  tgaccaata  actgggaaa  1680
aggtagtca  agagaaagg  taaaaggtc  tgctgttac  ggtgtagtt  gtgtgcata  1740
ataatactt  cgaattaaa  tatttaata  ttgactgat  tcaataact  tgaaaataa  1800
aaggtgttg  attgcttgt  ag  1822



<210> 2789
<211> 574
<212> PRT
<213> Homo sapiens
<308> P36406
<400> 2789

Met Ala Thr Leu Val Val Asn Lys Leu Gly Ala Gly Val Asp Ser Gly 
  1               5                  10                  15
Arg Gln Gly Ser Arg Gly Thr Ala Val Val Lys Val Leu Glu Cys Gly 
             20                  25                  30
Val Cys Glu Asp Val Phe Ser Leu Gln Gly Asp Lys Val Pro Arg Leu 
         35                  40                  45
Leu Leu Cys Gly His Thr Val Cys His Asp Cys Leu Thr Arg Leu Pro 
     50                  55                  60
Leu His Gly Arg Ala Ile Arg Cys Pro Phe Asp Arg Gln Val Thr Asp 
 65                  70                  75                  80
Leu Gly Asp Ser Gly Val Trp Gly Leu Lys Lys Asn Phe Ala Leu Leu 
                 85                  90                  95
Glu Leu Leu Glu Arg Leu Gln Asn Gly Pro Ile Gly Gln Tyr Gly Ala 
             100                105                110
Ala Glu Glu Ser Ile Gly Ile Ser Gly Glu Ser Ile Ile Arg Cys Asp 
         115                120                125
Glu Asp Glu Ala His Leu Ala Ser Val Tyr Cys Thr Val Cys Ala Thr 
     130                135                140
His Leu Cys Ser Glu Cys Ser Gln Val Thr His Ser Thr Lys Thr Leu 
 145                150                155                160
Ala Lys His Arg Arg Val Pro Leu Ala Asp Lys Pro His Glu Lys Thr 
                 165                170                175
Met Cys Ser Gln His Gln Val His Ala Ile Glu Phe Val Cys Leu Glu 
             180                185                190
Glu Gly Cys Gln Thr Ser Pro Leu Met Cys Cys Val Cys Lys Glu Tyr 
         195                200                205
Gly Lys His Gln Gly His Lys His Ser Val Leu Glu Pro Glu Ala Asn 
     210                215                220
Gln Ile Arg Ala Ser Ile Leu Asp Met Ala His Cys Ile Arg Thr Phe 
 225                230                235                240
Thr Glu Glu Ile Ser Asp Tyr Ser Arg Lys Leu Val Gly Ile Val Gln 
                 245                250                255
His Ile Glu Gly Gly Glu Gln Ile Val Glu Asp Gly Ile Gly Met Ala 
             260                265                270
His Thr Glu His Val Pro Gly Thr Ala Glu Asn Ala Arg Ser Cys Ile 
         275                280                285
Arg Ala Tyr Phe Tyr Asp Leu His Glu Thr Leu Cys Arg Gln Glu Glu 
     290                295                300
Met Ala Leu Ser Val Val Asp Ala His Val Arg Glu Lys Leu Ile Trp 
 305                310                315                320
Leu Arg Gln Gln Gln Glu Asp Met Thr Ile Leu Leu Ser Glu Val Ser 
                 325                330                335
Ala Ala Cys Leu His Cys Glu Lys Thr Leu Gln Gln Asp Asp Cys Arg 
             340                345                350
Val Val Leu Ala Lys Gln Glu Ile Thr Arg Leu Leu Glu Thr Leu Gln 
         355                360                365
Lys Gln Gln Gln Gln Phe Thr Glu Val Ala Asp His Ile Gln Leu Asp 
     370                375                380
Ala Ser Ile Pro Val Thr Phe Thr Lys Asp Asn Arg Val His Ile Gly 
 385                390                395                400
Pro Lys Met Glu Ile Arg Val Val Thr Leu Gly Leu Asp Gly Ala Gly 
                 405                410                415
Lys Thr Thr Ile Leu Phe Lys Leu Lys Gln Asp Glu Phe Met Gln Pro 
             420                425                430
Ile Pro Thr Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Leu 
         435                440                445
Lys Phe Thr Ile Trp Asp Val Gly Gly Lys His Lys Leu Arg Pro Leu 
     450                455                460
Trp Lys His Tyr Tyr Leu Asn Thr Gln Ala Val Val Phe Val Val Asp 
 465                470                475                480
Ser Ser His Arg Asp Arg Ile Ser Glu Ala His Ser Glu Leu Ala Lys 
                 485                490                495
Leu Leu Thr Glu Lys Glu Leu Arg Asp Ala Leu Leu Leu Ile Phe Ala 
             500                505                510
Asn Lys Gln Asp Val Ala Gly Ala Leu Ser Val Glu Glu Ile Thr Glu 
         515                520                525
Leu Leu Ser Leu His Lys Leu Cys Cys Gly Arg Ser Trp Tyr Ile Gln 
     530                535                540
Gly Cys Asp Ala Arg Ser Gly Met Gly Leu Tyr Glu Gly Leu Asp Trp 
 545                550                555                560
Leu Ser Arg Gln Leu Val Ala Ala Gly Val Leu Asp Val Ala 
                 565                570



<210> 2790
<211> 3844
<212> DNA
<213> Rattus norvegicus
<308> L05435
<400> 2790

cctcagccc  gtggctgga  cccctccct  acccgggga  tccctgacc  ggggaacca  60
gctcaggtc  ccagagcct  ccagaagaa  aataggcag  cctccctga  atatcttgg  120
tcctcagtt  atcctttcc  acctggctc  cccttccca  ttcccctcc  tactccctg  180
ctccctccc  aactcaccc  actgaactg  gtgcagagc  aagcccttt  cgccctttt  240
cccatctgg  cttctctgg  cagttcctc  tagtccgat  ccaaagaca  tggaacaca  300
ttctaaagg  tcttcttga  ccctccaat  cattgagca  agggctgaa  aagaagcag  360
gagtaaggt  gagccagtg  ctcgccccc  agccccatc  tggaagaag  ctttcgaga  420
cgagcagcg  tcatccgtg  ggccaaaga  attgccaag  aagttaaga  gcacgcggc  480
aagaaggtg  tgaagggtc  cgacagagt  caggatgaa  attcccgaa  gtcctactc  540
cgctttgag  aggaggagg  tgatgatga  ttccctgcc  ctgctgacg  ctattaccg  600
ggagaaggg  cccaggatg  ggaggaagg  ggcgcttcc  gtgatgcca  tgagggcca  660
gatgaggat  atgagatct  cgagggaga  tatcagggc  tcccccggg  agagtctgg  720
ggcaaaggc  aacggatgg  agatggggc  cccctggct  gagtgagag  gggcttaag  780
gatggggag  gtccccctg  gggtcgcgg  gaggcgcag  ggcgtaaag  tcgggaaga  840
ttggctcag  agtatgaga  catcctccg  gagtgcggc  atggtcgct  ccagtggac  900
ctctacttc  tgctgggtc  ggcgctgat  gccgatggt  tagaggtct  tgtggtggg  960
tttgtgctg  ccagtgctg  gaaagatat  tgcctgtcg  actccaaca  aggcatgct  1020
ggcctcatt  tgtacctgg  catgatggt  ggggccttc  tctggggag  cctggctga  1080
cggctgggt  ggagacagt  tctgctcat  tcgctctca  tcaacagcg  cttcgcttt  1140
ttctcatcc  tcgtccagg  ttatggcac  ttccttttc  gccgcctcc  ttctggggt  1200
gggattggt  gttccatcc  cattgtctt  tcctatttt  cggagtttc  ggcccagga  1260
aaacgtggg  agcatttga  ctggctctg  atgttctgg  tgattggtg  cgtgtatgc  1320
gctgcaatg  cctgggcca  catccccca  tatgggtgg  gtttccaga  gggctctgc  1380
taccagttc  acagctgga  ggtctttgt  ctcgtcttt  cctttccct  tgtgtttgc  1440
atcggggct  tgactacgc  gccggagag  ccccgcttc  tcttagaga  tgggaagca  1500
gatgaggcc  ggatggtgc  gaagcaggt  catgacacc  acatgcgag  caagggcca  1560
cctgagcga  tcttctcag  aacccacat  aaaacgatt  atcaggagg  tgaattgat  1620
gagatccag  cagacacag  aacctggta  cagcgctgg  gagtgcggg  tttgagcct  1680
gggggtcag  tttggggga  cttcctctc  tgcttcagt  cagagtacc  gcgcatcac  1740
ctgatgatg  tgggggtat  gttcaccat  tccttcagc  actacggtt  gactgtctg  1800
tttcccgac  tgatccgcc  tctccaggc  gtggactat  cagcccgaa  caaagtgtt  1860
ccaggggag  gcgtggagc  cgtgacatt  aacttcaca  tggagaatc  gatccaccg  1920
gggggacag  acttcaatg  caagttcat  gggctgcgt  tgaagtcag  gtcctttga  1980
gattccctg  ttgaggaat  ttactttga  gatgtcaca  ccagcaaca  attcttccg  2040
aactgcaca  tcatcaaca  cgtgttcta  aacacggac  tgtttgagt  caagttcgt  2100
aacagccgc  tggtgaaca  cacattcct  cacaataag  aaggttgcc  actagatgt  2160
acagggacg  gcgaaggtg  ctacatggt  tactttgtc  gcttcttgg  gacactggc  2220
gtgctccct  gaaatattg  gtctgctct  ctcatggac  agattggca  gctcagaat  2280
cttgctggt  ccagtgtgt  gtcctgtgt  tcctgcttc  tcctgtctt  tgggaacag  2340
gagtcagcc  tgatcgctc  gctctgcct  tttggggga  tcagtattg  atcctggaa  2400
gcgctggac  tgctgactg  tgaactcta  ccttccgac  agaggacga  ggccttcgg  2460
ttcctgaat  ccctgtgta  gctggcagc  gtactgggc  tcagcatct  cacgtcctt  2520
gtgggaatc  ccaaggccg  tcccatcct  ttcgcctca  ctgcgcttg  ccttggtag  2580
tctctggct  tgaagctgc  tgagacccg  ggacaggtg  tgcagtgag  gatggggga  2640
tgtctcagg  gctttaggg  tggcaggca  actgtgacc  ataatttct  ttatcccta  2700
cctgccctg  tgtcctggt  ctactccgt  tttggtgtc  tagctgtgt  cctgtgtgc  2760
tgtgtgtga  cctgacggg  aggggctac  gggagggtc  ctttgtccc  tgtttggga  2820
gagggactc  ccacctgct  ccaccctca  ctttgcaca  ggagaaggc  gagctgcat  2880
cttctctcc  tcagtgtta  caggggtgg  gacgactgt  tctctgctc  aggtgttcc  2940
gaatttctg  ctttcccat  attccctcc  cctaggccc  ggtgaacca  aggtatgga  3000
ttatagtgg  ggctgaggc  tggaccaaa  gaacttctt  agtgggagc  tcccaagga  3060
gctggggag  agcaataaa  cttagcctc  gttttcacc  caattcagg  tacaagtgt  3120
aagcctgga  tttatggaa  tagttttct  attcttatt  atatgtaag  tctgaggca  3180
cttagctgg  ctgtgtgtg  atgtataca  acactcata  gtgtgtgtg  gtgcgccgc  3240
tgcgtgtgc  tgtgtgtat  tgtgccatg  ggtaggggt  ccactatac  gttcaatta  3300
aagccaaga  tagtagttt  agtgagcac  cacacaaca  tgtttttct  tcgtaactc  3360
cagaatctt  tacctgtgt  ggggctgca  gcagaagtc  ttggtcagg  tggggtgag  3420
cctgcaatc  tgggggacc  gagggcacc  gacaaggac  ttctccttc  tctagagag  3480
ttctaccca  tagccacag  cctcccatc  gacctgtcc  cacaggcag  gtatcagag  3540
aaagaaagg  aaaataacc  ggcacacat  gtcaaacca  caggtctga  agcacaaga  3600
gctggggca  gggcaggaa  caggggtcc  tcccctaac  cttctcaaa  aggctgggt  3660
gtgagggac  cctaatgca  ggacctgaa  cctcagttt  cccatcttg  ccttccaca  3720
aacagcctc  gtaggtaga  ctgcccccc  tcctaccct  ctcttgtgg  tgctttctt  3780
ggtactctt  ccactccca  cgtagctgt  acgtgttgt  gtttttagc  gtttgtaaa  3840
tgtt  3844



<210> 2791
<211> 742
<212> PRT
<213> Rattus norvegicus
<308> Q02563
<400> 2791

Met Glu Glu Gly Phe Arg Asp Arg Ala Ala Phe Ile Arg Gly Ala Lys 
  1               5                  10                  15
Asp Ile Ala Lys Glu Val Lys Lys His Ala Ala Lys Lys Val Val Lys 
             20                  25                  30
Gly Leu Asp Arg Val Gln Asp Glu Tyr Ser Arg Arg Ser Tyr Ser Arg 
         35                  40                  45
Phe Glu Glu Glu Glu Asp Asp Asp Asp Phe Pro Ala Pro Ala Asp Gly 
     50                  55                  60
Tyr Tyr Arg Gly Glu Gly Ala Gln Asp Glu Glu Glu Gly Gly Ala Ser 
 65                  70                  75                  80
Ser Asp Ala Thr Glu Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly 
                 85                  90                  95
Glu Tyr Gln Gly Ile Pro Arg Ala Glu Ser Gly Gly Lys Gly Glu Arg 
             100                105                110
Met Ala Asp Gly Ala Pro Leu Ala Gly Val Arg Gly Gly Leu Ser Asp 
         115                120                125
Gly Glu Gly Pro Pro Gly Gly Arg Gly Glu Ala Gln Arg Arg Lys Asp 
     130                135                140
Arg Glu Glu Leu Ala Gln Gln Tyr Glu Thr Ile Leu Arg Glu Cys Gly 
 145                150                155                160
His Gly Arg Phe Gln Trp Thr Leu Tyr Phe Val Leu Gly Leu Ala Leu 
                 165                170                175
Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val Leu Pro Ser 
             180                185                190
Ala Glu Lys Asp Met Cys Leu Ser Asp Ser Asn Lys Gly Met Leu Gly 
         195                200                205
Leu Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Leu Trp Gly Gly 
     210                215                220
Leu Ala Asp Arg Leu Gly Arg Arg Gln Cys Leu Leu Ile Ser Leu Ser 
 225                230                235                240
Val Asn Ser Val Phe Ala Phe Phe Ser Ser Phe Val Gln Gly Tyr Gly 
                 245                250                255
Thr Phe Leu Phe Cys Arg Leu Leu Ser Gly Val Gly Ile Gly Gly Ser 
             260                265                270
Ile Pro Ile Val Phe Ser Tyr Phe Ser Glu Phe Leu Ala Gln Glu Lys 
         275                280                285
Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met Ile Gly Gly 
     290                295                300
Val Tyr Ala Ala Ala Met Ala Trp Ala Ile Ile Pro His Tyr Gly Trp 
 305                310                315                320
Ser Phe Gln Met Gly Ser Ala Tyr Gln Phe His Ser Trp Arg Val Phe 
                 325                330                335
Val Leu Val Phe Ala Phe Pro Ser Val Phe Ala Ile Gly Ala Leu Thr 
             340                345                350
Thr Gln Pro Glu Ser Pro Arg Phe Phe Leu Glu Asn Gly Lys His Asp 
         355                360                365
Glu Ala Trp Met Val Leu Lys Gln Val His Asp Thr Asn Met Arg Ala 
     370                375                380
Lys Gly His Pro Glu Arg Val Phe Ser Val Thr His Ile Lys Thr Ile 
 385                390                395                400
His Gln Glu Asp Glu Leu Ile Glu Ile Gln Ser Asp Thr Gly Thr Trp 
                 405                410                415
Tyr Gln Arg Trp Gly Val Arg Ala Leu Ser Leu Gly Gly Gln Val Trp 
             420                425                430
Gly Asn Phe Leu Ser Cys Phe Ser Pro Glu Tyr Arg Arg Ile Thr Leu 
         435                440                445
Met Met Met Gly Val Trp Phe Thr Met Ser Phe Ser Tyr Tyr Gly Leu 
     450                455                460
Thr Val Trp Phe Pro Asp Met Ile Arg His Leu Gln Ala Val Asp Tyr 
 465                470                475                480
Ala Ala Arg Thr Lys Val Phe Pro Gly Glu Arg Val Glu His Val Thr 
                 485                490                495
Phe Asn Phe Thr Leu Glu Asn Gln Ile His Arg Gly Gly Gln Tyr Phe 
             500                505                510
Asn Asp Lys Phe Ile Gly Leu Arg Leu Lys Ser Val Ser Phe Glu Asp 
         515                520                525
Ser Leu Phe Glu Glu Cys Tyr Phe Glu Asp Val Thr Ser Ser Asn Thr 
     530                535                540
Phe Phe Arg Asn Cys Thr Phe Ile Asn Thr Val Phe Tyr Asn Thr Asp 
 545                550                555                560
Leu Phe Glu Tyr Lys Phe Val Asn Ser Arg Leu Val Asn Ser Thr Phe 
                 565                570                575
Leu His Asn Lys Glu Gly Cys Pro Leu Asp Val Thr Gly Thr Gly Glu 
             580                585                590
Gly Ala Tyr Met Val Tyr Phe Val Ser Phe Leu Gly Thr Leu Ala Val 
         595                600                605
Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Lys Ile Gly Arg 
     610                615                620
Leu Arg Met Leu Ala Gly Ser Ser Val Leu Ser Cys Val Ser Cys Phe 
 625                630                635                640
Phe Leu Ser Phe Gly Asn Ser Glu Ser Ala Met Ile Ala Leu Leu Cys 
                 645                650                655
Leu Phe Gly Gly Val Ser Ile Ala Ser Trp Asn Ala Leu Asp Val Leu 
             660                665                670
Thr Val Glu Leu Tyr Pro Ser Asp Lys Arg Thr Thr Ala Phe Gly Phe 
         675                680                685
Leu Asn Ala Leu Cys Lys Leu Ala Ala Val Leu Gly Ile Ser Ile Phe 
     690                695                700
Thr Ser Phe Val Gly Ile Thr Lys Ala Ala Pro Ile Leu Phe Ala Ser 
 705                710                715                720
Ala Ala Leu Ala Leu Gly Ser Ser Leu Ala Leu Lys Leu Pro Glu Thr 
                 725                730                735
Arg Gly Gln Val Leu Gln 
             740



<210> 2792
<211> 3190
<212> DNA
<213> Homo sapiens
<308> BC000776
<400> 2792

ggcacgagg  cacaacgac  gaaagaacg  gaagaactg  cccaacagt  tgaagccat  60
ctacgggag  gtggccacg  ccgcttcca  tggacactg  attttgtgc  tggtctggc  120
ctgatggct  acggtgtgg  ggtctttgt  gtgggcttc  tgctgccca  cgctgagaa  180
gacatgtgc  tgtccgact  caacaaagg  atgctaggc  tcatcgtct  cctgggcat  240
atggtggga  ccttcctct  gggaggtct  gctgaccgg  tgggtcgga  gcagtgtct  300
ctcatctcg  tctcagtca  cagcgtctt  gccttcttc  catcttttg  ccagggtta  360
ggcactttc  tcttctgcc  cctactttc  ggggttggg  ttggagggt  catccccat  420
gtcttctcc  atttctccg  gtttctggc  caggagaaa  gaggggagc  tttgagctg  480
ctctgcatg  tttggatga  tggtggcgt  tacgcagct  ctatggcct  ggccatcat  540
ccccactat  ggtggagtt  tcagatggg  tctgcctac  agttccata  ctggagggt  600
ttcgtcctc  tctgcgcct  tccttctgt  tttgccatt  gggctctga  cacgcagcc  660
gagagcccc  gtttcttcc  agagaatgg  aagcatgat  aggcctgga  ggtgctgaa  720
caggtccat  ataccaaca  gcgagccaa  ggacatcct  agcgagtgt  ctcagtaac  780
cacattaag  cgattcatc  ggaggatga  ttgattgag  tccagtcgg  cacagggac  840
tggtaccag  gctgggggg  ccgggcctt  agcctaggg  ggcaggttt  ggggaattt  900
ctctcctgt  ttggtcccg  atatcggcg  atcactctg  tgatgatgg  tgtgtggtt  960
accatgtca  tcagctact  tggcctgac  gtctggttt  ctgacatga  ccgccatct  1020
caggcagtg  actacgcat  ccgcaccaa  gtgttcccc  gggagcgcg  agagcatgt  1080
acttttaac  tcacgttgg  gaatcagat  caccgaggc  ggcagtact  caatgacaa  1140
ttcattggg  tgcggctca  gtcagtgtc  tttgaggat  ccctgtttg  agagtgtta  1200
tttgaggat  tcacatcca  caacacgtt  ttccgcaac  gcacattca  caacactgt  1260
ttctataac  ctgacctgt  cgagtacaa  tttgtgaac  gccgtctga  aaacagtac  1320
ttcctgcac  acaaggagg  ctgcccgct  gacgtgaca  ggacgggcg  aggtgccta  1380
atggtatac  ttgtgagct  cctggggac  ctggcagtg  ttcctggga  tatcgtgtc  1440
gccctgctc  tggacaaga  cggcaggct  agaatgctt  ctggctcca  cgtgatgtc  1500
tgtgtctcc  gcttcttcc  gtcttttgg  aacagtgag  cggccatga  cgctctgct  1560
tgccttttt  gcggggtca  cattgcatc  tggaatgcg  tggacgtgt  gactgttga  1620
ctctacccc  cagacaaga  gaccacagc  tttggcttc  tgaatgccc  gtgtaagct  1680
gcagctgtg  tggggatca  cattttcac  tccttcgtg  gaatcacca  ggctgcacc  1740
atcctcttt  cctcagctg  ccttgccct  ggcagctct  tggccctga  gctgcctga  1800
acccggggg  aggtgctgc  gtgaagggg  ctctagggc  ttgggattg  caggcacac  1860
gtgagacca  caactcctt  cttcccctc  ctgccctgc  atcctgacc  ccagagccc  1920
cactcccca  tccccgtgt  tggtgtctt  gctgtgtgt  cgtgtgcgt  tgcatgtgt  1980
taaaccccg  gggcaggga  tacagggaa  gctccttca  cccagtttt  agatgaagc  2040
gtactcccc  tttcccact  cccttgact  tgcacaaga  aaggctgag  cccatcctt  2100
tccccctgt  agagagggg  ccttgcttc  ctgttccag  ggttccaga  taggcttcc  2160
gccttcccc  tcattccct  tgcctaggc  ctggtgaaa  cacaggtat  caattatgc  2220
aggggctgg  gctctggtg  agaccatgg  ccaaaagaa  ttcttagag  ctgaagagt  2280
ggcctcggg  gccctctca  atctcctgt  ggatgctgg  ggagaagca  taaacctca  2340
ccctctggc  tccactttc  tctcaattt  ggctgcaaa  atgaagcct  aattttatg  2400
aattagctt  ctgattctt  tttattaat  gattaagtt  tgaggcagc  ccgcaggac  2460
gtgtgtgaa  gtgtatgta  acttacata  gtgtgtgca  gtgccatgg  gcggggggt  2520
tcactatac  gtcctcaaa  ataagccaa  ggtaatttc  gcggatgca  acacaaccc  2580
gcctcccac  gttcctccc  taatctggt  tctgtgttg  gcctgggat  gaggagccc  2640
aggccagcc  gggataaga  tcccacagt  tagggagat  tgagggcat  cgacaaggc  2700
catctcctt  cctcctcaa  aagcagagg  ctcctctgg  gtgagaggc  ccacccact  2760
cagcacagg  gggaatagc  cagctgccc  cccatgctc  ctacctgtc  cctcacagg  2820
aggggagca  gggagggaa  gaaaccagg  atctggtca  accagcaga  caaaaagca  2880
aaagagctg  ggcagaggc  ggaagcagg  gccctcctg  cagctcctc  gagtgggga  2940
aggttgggc  gtgagtgag  gacccctaa  gcagggact  gaagcctca  tttccccat  3000
ttacccttc  acacaatag  ctctgtagg  taggctgcc  catcccacc  tactctgtg  3060
ggctgcttt  tttggtgcc  tcccctcac  ccactgtag  tgtgacgtg  tgtagtttt  3120
agatgtttg  aaaatgttt  aaaaaatgt  aaaaggaaa  aagtgaaaa  aacaaaaaa  3180
aaaaaaaaaa  3190



<210> 2793
<211> 742
<212> PRT
<213> Homo sapiens
<308> NP_055664
<400> 2793

Met Glu Glu Gly Phe Arg Asp Arg Ala Ala Phe Ile Arg Gly Ala Lys 
  1               5                  10                  15
Asp Ile Ala Lys Glu Val Lys Lys His Ala Ala Lys Lys Val Val Lys 
             20                  25                  30
Gly Leu Asp Arg Val Gln Asp Glu Tyr Ser Arg Arg Ser Tyr Ser Arg 
         35                  40                  45
Phe Glu Glu Glu Asp Asp Asp Asp Asp Phe Pro Ala Pro Ser Asp Gly 
     50                  55                  60
Tyr Tyr Arg Gly Glu Gly Thr Gln Asp Glu Glu Glu Gly Gly Ala Ser 
 65                  70                  75                  80
Ser Asp Ala Thr Glu Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly 
                 85                  90                  95
Glu Tyr Gln Gly Ile Pro Arg Ala Glu Ser Gly Gly Lys Gly Glu Arg 
             100                105                110
Met Ala Asp Gly Ala Pro Leu Ala Gly Val Arg Gly Gly Leu Ser Asp 
         115                120                125
Gly Glu Gly Pro Pro Gly Gly Arg Gly Glu Ala Gln Arg Arg Lys Glu 
     130                135                140
Arg Glu Glu Leu Ala Gln Gln Tyr Glu Ala Ile Leu Arg Glu Cys Gly 
 145                150                155                160
His Gly Arg Phe Gln Trp Thr Leu Tyr Phe Val Leu Gly Leu Ala Leu 
                 165                170                175
Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val Leu Pro Ser 
             180                185                190
Ala Glu Lys Asp Met Cys Leu Ser Asp Ser Asn Lys Gly Met Leu Gly 
         195                200                205
Leu Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Leu Trp Gly Gly 
     210                215                220
Leu Ala Asp Arg Leu Gly Arg Arg Gln Cys Leu Leu Ile Ser Leu Ser 
 225                230                235                240
Val Asn Ser Val Phe Ala Phe Phe Ser Ser Phe Val Gln Gly Tyr Gly 
                 245                250                255
Thr Phe Leu Phe Cys Arg Leu Leu Ser Gly Val Gly Ile Gly Gly Ser 
             260                265                270
Ile Pro Ile Val Phe Ser Tyr Phe Ser Glu Phe Leu Ala Gln Glu Lys 
         275                280                285
Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met Ile Gly Gly 
     290                295                300
Val Tyr Ala Ala Ala Met Ala Trp Ala Ile Ile Pro His Tyr Gly Trp 
 305                310                315                320
Ser Phe Gln Met Gly Ser Ala Tyr Gln Phe His Ser Trp Arg Val Phe 
                 325                330                335
Val Leu Val Cys Ala Phe Pro Ser Val Phe Ala Ile Gly Ala Leu Thr 
             340                345                350
Thr Gln Pro Glu Ser Pro Arg Phe Phe Leu Glu Asn Gly Lys His Asp 
         355                360                365
Glu Ala Trp Met Val Leu Lys Gln Val His Asp Thr Asn Met Arg Ala 
     370                375                380
Lys Gly His Pro Glu Arg Val Phe Ser Val Thr His Ile Lys Thr Ile 
 385                390                395                400
His Gln Glu Asp Glu Leu Ile Glu Ile Gln Ser Asp Thr Gly Thr Trp 
                 405                410                415
Tyr Gln Arg Trp Gly Val Arg Ala Leu Ser Leu Gly Gly Gln Val Trp 
             420                425                430
Gly Asn Phe Leu Ser Cys Phe Gly Pro Glu Tyr Arg Arg Ile Thr Leu 
         435                440                445
Met Met Met Gly Val Trp Phe Thr Met Ser Phe Ser Tyr Tyr Gly Leu 
     450                455                460
Thr Val Trp Phe Pro Asp Met Ile Arg His Leu Gln Ala Val Asp Tyr 
 465                470                475                480
Ala Ser Arg Thr Lys Val Phe Pro Gly Glu Arg Val Glu His Val Thr 
                 485                490                495
Phe Asn Phe Thr Leu Glu Asn Gln Ile His Arg Gly Gly Gln Tyr Phe 
             500                505                510
Asn Asp Lys Phe Ile Gly Leu Arg Leu Lys Ser Val Ser Phe Glu Asp 
         515                520                525
Ser Leu Phe Glu Glu Cys Tyr Phe Glu Asp Val Thr Ser Ser Asn Thr 
     530                535                540
Phe Phe Arg Asn Cys Thr Phe Ile Asn Thr Val Phe Tyr Asn Thr Asp 
 545                550                555                560
Leu Phe Glu Tyr Lys Phe Val Asn Ser Arg Leu Ile Asn Ser Thr Phe 
                 565                570                575
Leu His Asn Lys Glu Gly Cys Pro Leu Asp Val Thr Gly Thr Gly Glu 
             580                585                590
Gly Ala Tyr Met Val Tyr Phe Val Ser Phe Leu Gly Thr Leu Ala Val 
         595                600                605
Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Lys Ile Gly Arg 
     610                615                620
Leu Arg Met Leu Ala Gly Ser Ser Val Met Ser Cys Val Ser Cys Phe 
 625                630                635                640
Phe Leu Ser Phe Gly Asn Ser Glu Ser Ala Met Ile Ala Leu Leu Cys 
                 645                650                655
Leu Phe Gly Gly Val Ser Ile Ala Ser Trp Asn Ala Leu Asp Val Leu 
             660                665                670
Thr Val Glu Leu Tyr Pro Ser Asp Lys Arg Thr Thr Ala Phe Gly Phe 
         675                680                685
Leu Asn Ala Leu Cys Lys Leu Ala Ala Val Leu Gly Ile Ser Ile Phe 
     690                695                700
Thr Ser Phe Val Gly Ile Thr Lys Ala Ala Pro Ile Leu Phe Ala Ser 
 705                710                715                720
Ala Ala Leu Ala Leu Gly Ser Ser Leu Ala Leu Lys Leu Pro Glu Thr 
                 725                730                735
Arg Gly Gln Val Leu Gln 
             740



<210> 2794
<211> 1550
<212> DNA
<213> Rattus norvegicus
<308> L05489
<400> 2794

gggcccccc  gtctccgcc  ggctcggga  catgaagct  ctgccgtcg  tggtgctga  60
gctctttct  gccgcagtg  tgtccgcgt  ggtgaccgg  gagagtctg  agcggcttc  120
gagaggtct  gcggcagca  ccagcaacc  tgaccctcc  actggaacc  caaaccagc  180
gctacccac  ggagctgat  gcgctcagg  ggtccagga  ttggaaggg  ccgatctgg  240
ccttttcaa  gttgctttc  cctccaagc  acaagccct  gccacccca  gaaaagaaa  300
gaacgggaa  aagaagagg  aaggcaagg  gttaggaaa  aagagagat  catgcctta  360
gaaatacaa  gactactgc  tccacggag  gtgcagata  ctgaaggag  tccgtattc  420
ctcgtgcca  tgcctccct  gttaccatg  acagaggtg  catgggctg  ccctaccgg  480
agagaaccc  ctgtacaca  atgaccaca  taccgtctt  gctgtggtg  ctgtagtac  540
gtcatctgt  tgtcttctt  tcatcgtgg  acttctcat  ttcaggtac  ataggcgag  600
aggttatga  ttggaaagt  aggagaaag  gaagttggg  atggctagc  cccactgag  660
aggatctga  ctcaaggag  cttcagagg  tggctactt  tgagatggc  gttccttac  720
agttctaca  agggaaaat  cttcaccag  agccatgaa  acttcttca  tcattccca  780
ttgctaccc  gactgggcc  cctgtaatt  ctctgcaaa  atatcagag  ctctaagtg  840
caaacagac  atgccccgc  gggatctgg  tcagaagaa  gcaggagca  gtgagccct  900
caggccttc  tgatcctcc  ccactgaac  cactggttt  tttaaacac  tagcttctg  960
attaaagtg  cagctagtt  ccatatgct  caggatttt  ggctgaaaa  aaaaaaaga  1020
gagaggacg  atgagtggt  tatggactg  aagagatca  cagagttga  aagctaagt  1080
ttcaagtag  cacagggga  ctgctgttt  gaccctcca  cacgctgga  ttgatgagc  1140
aactgtgaa  tatctcaag  ccgagaact  ttgagtttt  ggacttcta  ccagaggga  1200
aaataacaa  tattttgtt  ttgttgttg  ttgtttgtt  ttaaaatgc  tcttaaatt  1260
tatatttat  ttattctat  tatgttaat  tatttagtt  ttaacaatc  aacaataat  1320
tttcaagtg  ctagactgt  actttgcca  tgtcctggc  cgcctctct  gcagctctt  1380
cacctggct  aatgccaca  tcccatctg  tctgtaacc  atctgtagt  atttattgt  1440
tgtctacat  tcagaagat  cccctgtag  agagtatcc  agggtgggt  gtgtatggt  1500
ggagtgcaa  gatggattt  ggcagagcc  ctctgtgag  tggactgcag  1550



<210> 2795
<211> 208
<212> PRT
<213> Rattus norvegicus
<308> Q06175
<400> 2795

Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val 
  1               5                  10                  15
Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
             20                  25                  30
Leu Ala Ala Ala Thr Ser Asn Pro Asp Pro Pro Thr Gly Thr Thr Asn 
         35                  40                  45
Gln Leu Leu Pro Thr Gly Ala Asp Arg Ala Gln Glu Val Gln Asp Leu 
     50                  55                  60
Glu Gly Thr Asp Leu Asp Leu Phe Lys Val Ala Phe Ser Ser Lys Pro 
 65                  70                  75                  80
Gln Ala Leu Ala Thr Pro Gly Lys Glu Lys Asn Gly Lys Lys Lys Arg 
                 85                  90                  95
Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Lys Lys Tyr 
             100                105                110
Lys Asp Tyr Cys Ile His Gly Glu Cys Arg Tyr Leu Lys Glu Leu Arg 
         115                120                125
Ile Pro Ser Cys His Cys Leu Pro Gly Tyr His Gly Gln Arg Cys His 
     130                135                140
Gly Leu Thr Leu Pro Val Glu Asn Pro Leu Tyr Thr Tyr Asp His Thr 
 145                150                155                160
Thr Val Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                 165                170                175
Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
             180                185                190
Asp Leu Glu Ser Glu Glu Lys Val Lys Leu Gly Met Ala Ser Ser His 
         195                200                205



<210> 2796
<211> 2360
<212> DNA
<213> Homo sapiens
<308> M60278
<400> 2796

gctacgcgg  ccacgctgc  ggctggcct  acctaggcg  gcggggtcg  gcggccgcg  60
gggcgggct  agtgagcaa  acaagacac  caagaagag  gagctgcgc  tgggtcccg  120
ccaggcttg  acgcagagg  gggcggcag  cggtgcccg  cggaatctc  tgagctccg  180
cgcccagct  tggtgccag  gcccagtgg  cgccgcttc  aaagtgact  gtgcctcgc  240
gcctcctct  ggtgcggga  catgaagct  ctgccgtcg  tggtgctga  gctctttct  300
gctgcagtt  tctcggcac  ggtgactgg  gagagcctg  agcggcttc  gagagggct  360
gctgctgga  ccagcaacc  ggaccctcc  actgtatcc  cggaccagc  gctacccct  420
ggaggcggc  gggaccgga  agtccgtga  ttgcaagag  cagatctgg  ccttttgag  480
gtcacttta  cctccaagc  acaagcact  gccacacca  acaaggagg  gcacgggaa  540
agaaagaag  aaggcaagg  gctagggaa  aagagggac  catgtcttc  gaaatacaa  600
gacttctgc  tccatggag  atgcaaata  gtgaaggag  tccgggctc  ctcctgcat  660
tgccacccg  gttaccatg  agagaggtg  catgggctg  gcctcccag  ggaaaatcg  720
ttatatacc  atgaccaca  aaccatcct  gccgtggtg  ctgtggtgc  gtcatctgt  780
tgtctgctg  tcatcgtgg  gcttctcat  tttaggtac  ataggagag  aggttatga  840
gtggaaaat  aagagaaag  gaagttggg  atgactaat  cccactgag  gagacttgt  900
ctcaaggaa  cggctgggg  ctgctacct  tgagaagac  caaggtgat  tcagactgc  960
gaggggaaa  acttccatc  agtcacaaa  actccttcg  ccccagttg  cgtctagga  1020
tgggcctcc  ataattgct  tgccaaaat  ccagagcct  caagtgcca  acagagtat  1080
tccgatggt  tctgggtaa  aagaaagca  aagcaaggg  ccttcatgc  cttctgatt  1140
ccctccacc  aaccccact  cccctcata  gtttgttta  acacttatc  tctggatta  1200
aatgccggt  aaattccat  tgctccagg  tctttgact  aaaaaaaaa  agaagaaga  1260
gaaggagag  aagaaggaa  gatttgtga  ctggaagaa  gcaacaaag  ttgagaagc  1320
atgtactca  gtaccacca  gggatctgc  attgggacc  tccagtgct  gatttgatg  1380
gttaactgt  aaataccac  agcctgaga  ctgaatttt  ggacttcta  ccagatgga  1440
aaataacaa  tatttttgt  gttgttgtt  gtaaatgcc  cttaaatta  atatttatt  1500
tattctatg  atgttaatt  atttagttt  taacaatct  acaataata  ttcaagtgc  1560
tagactgtt  ctttggcaa  ttcctggcc  tccactcct  atccccaca  tctggctta  1620
tgccaccca  ctttgccac  aagctagga  ggttctgtg  cccatctgt  gtaatttat  1680
gtctgtcta  atttctgca  atcttccgt  gtcagagtg  cactgcggg  gctctgtat  1740
gtcaggatg  aggggttaa  ttggtcaga  ccactctat  agttggact  cagtcttgc  1800
taggcgatt  tgtctacca  ttgtgtttt  aaagcccaa  gtgctgatg  caaagtgta  1860
cagatatca  tgtctcccc  tgtcctctc  ctgccaagt  tcagaagag  ttgggcttc  1920
atgcctgta  ctttcctgg  ccctcaccc  catggcccc  ggccacagc  tgggaactc  1980
ctttccctt  tgtcaagac  tttctctaa  tcctgccat  cttctggtg  tactccatg  2040
aggggtcag  gcagcagag  acagtctgg  gaaggtatt  gcaaagcaa  aggctgaga  2100
ggaacaggg  acattggag  tgactgttc  tggtaactg  ttacctgcc  attgctacc  2160
agaaggttg  aggtgggga  ggctttgta  aatcccacc  acctcacca  aacgatgaa  2220
gtatgctgt  atggtcctt  ctggaagtt  ctggtgcca  ttctgaact  ttacaactt  2280
tatttccaa  cctggttca  atttatact  tgcaatcca  ataaagata  cccttattc  2340
ataaaaaaa  aaaaaaaaaa  2360



<210> 2797
<211> 208
<212> PRT
<213> Homo sapiens
<308> Q99075
<400> 2797

Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val 
  1               5                  10                  15
Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
             20                  25                  30
Leu Ala Ala Gly Thr Ser Asn Pro Asp Pro Pro Thr Val Ser Thr Asp 
         35                  40                  45
Gln Leu Leu Pro Leu Gly Gly Gly Arg Asp Arg Lys Val Arg Asp Leu 
     50                  55                  60
Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser Lys Pro 
 65                  70                  75                  80
Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg Lys Lys 
                 85                  90                  95
Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr 
             100                105                110
Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu Arg 
         115                120                125
Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys His 
     130                135                140
Gly Leu Ser Leu Pro Val Glu Asn Arg Leu Tyr Thr Tyr Asp His Thr 
 145                150                155                160
Thr Ile Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                 165                170                175
Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
             180                185                190
Asp Val Glu Asn Glu Glu Lys Val Lys Leu Gly Met Thr Asn Ser His 
         195                200                205



<210> 2798
<211> 1550
<212> DNA
<213> Rattus norvegicus
<308> L05489
<400> 2798

gggcccccc  gtctccgcc  ggctcggga  catgaagct  ctgccgtcg  tggtgctga  60
gctctttct  gccgcagtg  tgtccgcgt  ggtgaccgg  gagagtctg  agcggcttc  120
gagaggtct  gcggcagca  ccagcaacc  tgaccctcc  actggaacc  caaaccagc  180
gctacccac  ggagctgat  gcgctcagg  ggtccagga  ttggaaggg  ccgatctgg  240
ccttttcaa  gttgctttc  cctccaagc  acaagccct  gccacccca  gaaaagaaa  300
gaacgggaa  aagaagagg  aaggcaagg  gttaggaaa  aagagagat  catgcctta  360
gaaatacaa  gactactgc  tccacggag  gtgcagata  ctgaaggag  tccgtattc  420
ctcgtgcca  tgcctccct  gttaccatg  acagaggtg  catgggctg  ccctaccgg  480
agagaaccc  ctgtacaca  atgaccaca  taccgtctt  gctgtggtg  ctgtagtac  540
gtcatctgt  tgtcttctt  tcatcgtgg  acttctcat  ttcaggtac  ataggcgag  600
aggttatga  ttggaaagt  aggagaaag  gaagttggg  atggctagc  cccactgag  660
aggatctga  ctcaaggag  cttcagagg  tggctactt  tgagatggc  gttccttac  720
agttctaca  agggaaaat  cttcaccag  agccatgaa  acttcttca  tcattccca  780
ttgctaccc  gactgggcc  cctgtaatt  ctctgcaaa  atatcagag  ctctaagtg  840
caaacagac  atgccccgc  gggatctgg  tcagaagaa  gcaggagca  gtgagccct  900
caggccttc  tgatcctcc  ccactgaac  cactggttt  tttaaacac  tagcttctg  960
attaaagtg  cagctagtt  ccatatgct  caggatttt  ggctgaaaa  aaaaaaaga  1020
gagaggacg  atgagtggt  tatggactg  aagagatca  cagagttga  aagctaagt  1080
ttcaagtag  cacagggga  ctgctgttt  gaccctcca  cacgctgga  ttgatgagc  1140
aactgtgaa  tatctcaag  ccgagaact  ttgagtttt  ggacttcta  ccagaggga  1200
aaataacaa  tattttgtt  ttgttgttg  ttgtttgtt  ttaaaatgc  tcttaaatt  1260
tatatttat  ttattctat  tatgttaat  tatttagtt  ttaacaatc  aacaataat  1320
tttcaagtg  ctagactgt  actttgcca  tgtcctggc  cgcctctct  gcagctctt  1380
cacctggct  aatgccaca  tcccatctg  tctgtaacc  atctgtagt  atttattgt  1440
tgtctacat  tcagaagat  cccctgtag  agagtatcc  agggtgggt  gtgtatggt  1500
ggagtgcaa  gatggattt  ggcagagcc  ctctgtgag  tggactgcag  1550



<210> 2799
<211> 208
<212> PRT
<213> Rattus norvegicus
<308> Q06175
<400> 2799

Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val 
  1               5                  10                  15
Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
             20                  25                  30
Leu Ala Ala Ala Thr Ser Asn Pro Asp Pro Pro Thr Gly Thr Thr Asn 
         35                  40                  45
Gln Leu Leu Pro Thr Gly Ala Asp Arg Ala Gln Glu Val Gln Asp Leu 
     50                  55                  60
Glu Gly Thr Asp Leu Asp Leu Phe Lys Val Ala Phe Ser Ser Lys Pro 
 65                  70                  75                  80
Gln Ala Leu Ala Thr Pro Gly Lys Glu Lys Asn Gly Lys Lys Lys Arg 
                 85                  90                  95
Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Lys Lys Tyr 
             100                105                110
Lys Asp Tyr Cys Ile His Gly Glu Cys Arg Tyr Leu Lys Glu Leu Arg 
         115                120                125
Ile Pro Ser Cys His Cys Leu Pro Gly Tyr His Gly Gln Arg Cys His 
     130                135                140
Gly Leu Thr Leu Pro Val Glu Asn Pro Leu Tyr Thr Tyr Asp His Thr 
 145                150                155                160
Thr Val Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                 165                170                175
Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
             180                185                190
Asp Leu Glu Ser Glu Glu Lys Val Lys Leu Gly Met Ala Ser Ser His 
         195                200                205



<210> 2800
<211> 2360
<212> DNA
<213> Homo sapiens
<308> M60278
<400> 2800

gctacgcgg  ccacgctgc  ggctggcct  acctaggcg  gcggggtcg  gcggccgcg  60
gggcgggct  agtgagcaa  acaagacac  caagaagag  gagctgcgc  tgggtcccg  120
ccaggcttg  acgcagagg  gggcggcag  cggtgcccg  cggaatctc  tgagctccg  180
cgcccagct  tggtgccag  gcccagtgg  cgccgcttc  aaagtgact  gtgcctcgc  240
gcctcctct  ggtgcggga  catgaagct  ctgccgtcg  tggtgctga  gctctttct  300
gctgcagtt  tctcggcac  ggtgactgg  gagagcctg  agcggcttc  gagagggct  360
gctgctgga  ccagcaacc  ggaccctcc  actgtatcc  cggaccagc  gctacccct  420
ggaggcggc  gggaccgga  agtccgtga  ttgcaagag  cagatctgg  ccttttgag  480
gtcacttta  cctccaagc  acaagcact  gccacacca  acaaggagg  gcacgggaa  540
agaaagaag  aaggcaagg  gctagggaa  aagagggac  catgtcttc  gaaatacaa  600
gacttctgc  tccatggag  atgcaaata  gtgaaggag  tccgggctc  ctcctgcat  660
tgccacccg  gttaccatg  agagaggtg  catgggctg  gcctcccag  ggaaaatcg  720
ttatatacc  atgaccaca  aaccatcct  gccgtggtg  ctgtggtgc  gtcatctgt  780
tgtctgctg  tcatcgtgg  gcttctcat  tttaggtac  ataggagag  aggttatga  840
gtggaaaat  aagagaaag  gaagttggg  atgactaat  cccactgag  gagacttgt  900
ctcaaggaa  cggctgggg  ctgctacct  tgagaagac  caaggtgat  tcagactgc  960
gaggggaaa  acttccatc  agtcacaaa  actccttcg  ccccagttg  cgtctagga  1020
tgggcctcc  ataattgct  tgccaaaat  ccagagcct  caagtgcca  acagagtat  1080
tccgatggt  tctgggtaa  aagaaagca  aagcaaggg  ccttcatgc  cttctgatt  1140
ccctccacc  aaccccact  cccctcata  gtttgttta  acacttatc  tctggatta  1200
aatgccggt  aaattccat  tgctccagg  tctttgact  aaaaaaaaa  agaagaaga  1260
gaaggagag  aagaaggaa  gatttgtga  ctggaagaa  gcaacaaag  ttgagaagc  1320
atgtactca  gtaccacca  gggatctgc  attgggacc  tccagtgct  gatttgatg  1380
gttaactgt  aaataccac  agcctgaga  ctgaatttt  ggacttcta  ccagatgga  1440
aaataacaa  tatttttgt  gttgttgtt  gtaaatgcc  cttaaatta  atatttatt  1500
tattctatg  atgttaatt  atttagttt  taacaatct  acaataata  ttcaagtgc  1560
tagactgtt  ctttggcaa  ttcctggcc  tccactcct  atccccaca  tctggctta  1620
tgccaccca  ctttgccac  aagctagga  ggttctgtg  cccatctgt  gtaatttat  1680
gtctgtcta  atttctgca  atcttccgt  gtcagagtg  cactgcggg  gctctgtat  1740
gtcaggatg  aggggttaa  ttggtcaga  ccactctat  agttggact  cagtcttgc  1800
taggcgatt  tgtctacca  ttgtgtttt  aaagcccaa  gtgctgatg  caaagtgta  1860
cagatatca  tgtctcccc  tgtcctctc  ctgccaagt  tcagaagag  ttgggcttc  1920
atgcctgta  ctttcctgg  ccctcaccc  catggcccc  ggccacagc  tgggaactc  1980
ctttccctt  tgtcaagac  tttctctaa  tcctgccat  cttctggtg  tactccatg  2040
aggggtcag  gcagcagag  acagtctgg  gaaggtatt  gcaaagcaa  aggctgaga  2100
ggaacaggg  acattggag  tgactgttc  tggtaactg  ttacctgcc  attgctacc  2160
agaaggttg  aggtgggga  ggctttgta  aatcccacc  acctcacca  aacgatgaa  2220
gtatgctgt  atggtcctt  ctggaagtt  ctggtgcca  ttctgaact  ttacaactt  2280
tatttccaa  cctggttca  atttatact  tgcaatcca  ataaagata  cccttattc  2340
ataaaaaaa  aaaaaaaaaa  2360



<210> 2801
<211> 208
<212> PRT
<213> Homo sapiens
<308> Q99075
<400> 2801

Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val 
  1               5                  10                  15
Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
             20                  25                  30
Leu Ala Ala Gly Thr Ser Asn Pro Asp Pro Pro Thr Val Ser Thr Asp 
         35                  40                  45
Gln Leu Leu Pro Leu Gly Gly Gly Arg Asp Arg Lys Val Arg Asp Leu 
     50                  55                  60
Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser Lys Pro 
 65                  70                  75                  80
Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg Lys Lys 
                 85                  90                  95
Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr 
             100                105                110
Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu Arg 
         115                120                125
Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys His 
     130                135                140
Gly Leu Ser Leu Pro Val Glu Asn Arg Leu Tyr Thr Tyr Asp His Thr 
 145                150                155                160
Thr Ile Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                 165                170                175
Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
             180                185                190
Asp Val Glu Asn Glu Glu Lys Val Lys Leu Gly Met Thr Asn Ser His 
         195                200                205



<210> 2802
<211> 258
<212> DNA
<213> Rattus norvegicus
<308> L05557
<400> 2802

ccctcccct  ccccaaccc  cctccaaat  ccctcggaa  ggcccagca  acttctgac  60
aaagtgttt  ccttgcaga  ccgcgtcgt  aaggcgttc  gtagctctc  ctatgaagg  120
ttagaaaaa  ccgagtctc  aacctccat  cataacttc  tggctcatc  tgaattccg  180
atcgaagat  cccagcccc  catccccct  atcgatgac  ccgacctgg  agaagatgc  240
gcgctcaag  agaactcg  258



<210> 2803
<211> 1243
<212> PRT
<213> Rattus norvegicus
<308> AAB60703
<400> 2803

Met Gly Asp Met Thr Asn Ser Asp Phe Tyr Ser Lys Asn Gln Arg Asn 
  1               5                  10                  15
Glu Ser Ser His Gly Gly Glu Phe Gly Cys Ser Met Glu Glu Leu Arg 
             20                  25                  30
Ser Leu Met Glu Leu Arg Gly Thr Glu Ala Val Val Lys Ile Lys Glu 
         35                  40                  45
Thr Tyr Gly Asp Thr Glu Ser Ile Cys Arg Arg Leu Lys Thr Ser Pro 
     50                  55                  60
Val Glu Gly Leu Pro Gly Thr Ala Pro Asp Leu Glu Lys Arg Lys Gln 
 65                  70                  75                  80
Ile Phe Gly Gln Asn Phe Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu 
                 85                  90                  95
Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu 
             100                105                110
Ile Ala Ala Ile Ile Ser Leu Gly Leu Ser Phe Tyr His Pro Pro Gly 
         115                120                125
Glu Ser Asn Glu Gly Cys Ala Thr Ala Gln Gly Gly Ala Glu Asp Glu 
     130                135                140
Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Leu Ser 
 145                150                155                160
Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu 
                 165                170                175
Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln Lys Phe 
             180                185                190
Thr Val Val Arg Ala Gly Gln Val Val Gln Ile Pro Val Ala Glu Ile 
         195                200                205
Val Val Gly Asp Ile Ala Gln Ile Lys Tyr Gly Asp Leu Leu Pro Ala 
     210                215                220
Asp Gly Leu Phe Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser 
 225                230                235                240
Leu Thr Gly Glu Ser Asp Gln Val Arg Lys Ser Val Asp Lys Asp Pro 
                 245                250                255
Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Val 
             260                265                270
Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe Thr Leu 
         275                280                285
Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys Lys Gly Val 
     290                295                300
Lys Lys Gly Asp Gly Leu Gln Leu Pro Ala Ala Asp Gly Ala Ala Pro 
 305                310                315                320
Ala Asn Ala Ala Gly Ser Ala Asn Ala Ser Leu Val Asn Gly Lys Met 
                 325                330                335
Gln Asp Gly Ser Ala Asp Ser Ser Gln Ser Lys Ala Lys Gln Gln Asp 
             340                345                350
Gly Ala Ala Ala Met Glu Met Gln Pro Leu Lys Ser Ala Glu Gly Gly 
         355                360                365
Asp Ala Asp Asp Lys Lys Lys Ala Asn Met His Lys Lys Glu Lys Ser 
     370                375                380
Val Leu Gln Gly Lys Leu Thr Lys Leu Ala Val Gln Ile Gly Lys Ala 
 385                390                395                400
Gly Leu Val Met Ser Ala Ile Thr Val Ile Ile Leu Val Leu Tyr Phe 
                 405                410                415
Thr Val Asp Thr Phe Val Val Asn Lys Lys Pro Trp Leu Thr Glu Cys 
             420                425                430
Thr Pro Val Tyr Val Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Val 
         435                440                445
Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr 
     450                455                460
Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu 
 465                470                475                480
Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile 
                 485                490                495
Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Arg Met Thr Val Val 
             500                505                510
Gln Ala Tyr Val Gly Asp Val His Tyr Lys Glu Ile Pro Asp Pro Ser 
         515                520                525
Ser Ile Asn Ala Lys Thr Leu Glu Leu Leu Val Asn Ala Ile Ala Ile 
     530                535                540
Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro Pro Glu Lys Glu Gly Ala 
 545                550                555                560
Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Gly Leu Leu Gly Phe 
                 565                570                575
Val Leu Asp Leu Arg Gln Asp Tyr Glu Pro Val Arg Ser Gln Met Pro 
             580                585                590
Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser 
         595                600                605
Met Ser Thr Val Ile Lys Met Pro Asp Glu Ser Phe Arg Met Tyr Ser 
     610                615                620
Lys Gly Ala Ser Glu Ile Val Leu Lys Lys Cys Cys Lys Ile Leu Ser 
 625                630                635                640
Gly Ala Gly Glu Pro Arg Val Phe Arg Pro Arg Asp Arg Asp Glu Met 
                 645                650                655
Val Lys Lys Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile 
             660                665                670
Cys Val Ala Tyr Arg Asp Phe Pro Ser Ser Pro Glu Pro Asp Trp Asp 
         675                680                685
Asn Glu Asn Asp Ile Leu Asn Glu Leu Thr Cys Ile Cys Val Val Gly 
     690                695                700
Ile Glu Asp Pro Val Arg Pro Glu Val Pro Glu Ala Ile Arg Lys Cys 
 705                710                715                720
Gln Arg Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn 
                 725                730                735
Thr Ala Arg Ala Ile Ala Ile Lys Cys Gly Ile Ile His Pro Gly Glu 
             740                745                750
Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Arg Ile Arg Asn 
         755                760                765
Glu Lys Gly Glu Ile Glu Gln Glu Arg Ile Asp Lys Ile Trp Pro Lys 
     770                775                780
Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val 
 785                790                795                800
Lys Gly Ile Ile Asp Ser Thr His Thr Glu Gln Arg Gln Val Val Ala 
                 805                810                815
Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp 
             820                825                830
Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala 
         835                840                845
Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Ser Ser Ile Val Lys Ala 
     850                855                860
Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln 
 865                870                875                880
Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly 
                 885                890                895
Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp 
             900                905                910
Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu 
         915                920                925
Pro Pro Thr Glu Thr Leu Leu Leu Arg Lys Pro Tyr Gly Arg Asn Lys 
     930                935                940
Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Val 
 945                950                955                960
Tyr Gln Leu Thr Leu Ile Phe Thr Leu Leu Phe Val Gly Glu Lys Met 
                 965                970                975
Phe Gln Ile Asp Ser Gly Arg Asn Ala Pro Leu His Ser Pro Pro Ser 
             980                985                990
Glu His Tyr Thr Ile Ile Phe Asn Thr Phe Val Met Met Gln Leu Phe 
         995                1000                1005
Asn Glu Ile Asn Ala Arg Lys Ile His Gly Glu Arg Asn Val Phe Asp 
     1010                1015                1020
Gly Ile Phe Arg Asn Pro Ile Phe Cys Thr Ile Val Leu Gly Thr Phe 
 1025                1030                1035                1040
Ala Ile Gln Ile Val Ile Val Gln Phe Gly Gly Lys Pro Phe Ser Cys 
                 1045                1050                1055
Ser Pro Leu Gln Leu Asp Gln Trp Met Trp Cys Ile Phe Ile Gly Leu 
             1060                1065                1070
Gly Glu Leu Val Trp Gly Gln Val Ile Ala Thr Ile Pro Thr Ser Arg 
         1075                1080                1085
Leu Lys Phe Leu Lys Glu Ala Gly Arg Leu Thr Gln Lys Glu Glu Ile 
     1090                1095                1100
Pro Glu Glu Glu Leu Asn Glu Asp Val Glu Glu Ile Asp His Ala Glu 
 1105                1110                1115                1120
Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg 
                 1125                1130                1135
Ile Gln Thr Gln Ile Arg Val Val Lys Ala Phe Arg Ser Ser Leu Tyr 
             1140                1145                1150
Glu Gly Leu Glu Lys Pro Glu Ser Arg Thr Ser Ile His Asn Phe Met 
         1155                1160                1165
Ala His Pro Glu Phe Arg Ile Glu Asp Ser Gln Pro His Ile Pro Leu 
     1170                1175                1180
Ile Asp Asp Thr Asp Leu Glu Glu Asp Ala Ala Leu Lys Gln Asn Ser 
 1185                1190                1195                1200
Ser Pro Pro Ser Ser Leu Asn Lys Asn Asn Ser Ala Ile Asp Ser Gly 
                 1205                1210                1215
Ile Asn Leu Thr Thr Asp Thr Ser Lys Ser Ala Thr Ser Ser Ser Pro 
             1220                1225                1230
Gly Ser Pro Ile His Ser Leu Glu Thr Ser Leu 
         1235                1240



<210> 2804
<211> 4398
<212> DNA
<213> Homo sapiens
<308> J04027
<400> 2804

ggccaaagg  caagatact  ctctgggaa  tgttgctgc  gatgctgct  tacaaagtc  60
tacaatgag  gtttggttt  agaaagatt  tcatactta  aagattttc  tcttggaaa  120
acatcaagt  aaaattaaa  tcttttggg  aacattttc  ttctgatat  ttatacttg  180
aatgggcga  atggcaaac  actcagttg  ttacagtgg  gtgaaaaac  ctttgaagg  240
agctaatca  gatggagac  ttggaatta  gctcgcaga  ctgcgggct  tcatggagc  300
caggtccac  gatgcatta  gaaaaatac  ggaaagcta  ggagatgtc  atggaattt  360
caccaaatt  aaaacatct  ccaatgaag  tttaagtgg  aaccctgca  atttagaaa  420
aagagaagc  gtgtttgga  agaatttta  acctcctaa  aagccaaaa  cctttcttc  480
attagtatg  gaagcatta  aagatgtca  tttaattat  ttagaaatt  cagccatag  540
atcattggg  ctttctttt  atcagcctc  agaagggga  aatgcactt  gtggagaag  600
ttctgttgg  gaggaagaa  gtgaaggtg  aactgggtg  attgaagga  ctgcaatcc  660
cttgtctgt  gtgtgtgtg  tgttagtaa  agctttcaa  gactggagt  aggagaaac  720
gtttagagg  ttgcagagc  gaattgaac  agaacagaa  ttcactgtc  tcaggggtg  780
tcaggtcat  cagatacct  tagctgaca  tactgttgg  gatattgct  aagtgaaat  840
tggtgatct  cttccagct  acggcatac  tattcaagg  aacgatctt  aaattgatg  900
aagctcatt  actggtgaa  cagatcatg  taaaaagtc  ttagataag  atcccttac  960
tctatcagg  actcatgta  gggaaggct  tggaagaat  gtagttaca  ctgtaggtg  1020
aaattctca  actggaatt  tctttacct  acttggagc  ggaggtgaa  aggaagaga  1080
gaaagatga  aagaaaaag  aaaagaaaa  taagaaaca  gatggagct  ttgagaatc  1140
caacaaagc  aaagcccag  atggtgcag  catggaaat  cagccattg  agagtgaag  1200
aggtggaga  ggtgatgaa  aagataaaa  gaaagcaaa  ttgccaaaa  aggaaaaat  1260
tgttttaca  gggaaactt  caaaactgg  tgttcagat  ggcaaagca  gtctgttga  1320
gtctgccat  acagttatc  ttctagtat  atattttgt  attgacacc  tctgggttc  1380
gaaaagacc  tggcttgct  agtgcacac  aatttatat  caatacttt  tgaagttct  1440
cattattgg  gttacagtt  tagtggtcg  agtgccaga  ggtcttcca  ttgcagtca  1500
gatctcact  gcttattca  tcaaaaaaa  gatgaaaga  aataactta  taaggcatc  1560
ggatgcttg  gaaaccatg  gaaatgcta  agctatttg  tcagataaa  caggaactt  1620
gacaatgaa  agaatgaca  tcgttcaag  ttacataaa  gaaaaacat  ataaaaagg  1680
tcctgaacc  gaagctatt  caccaaata  tttgtccta  cttgtaaca  gaatttctg  1740
gaattgtgc  tatacatca  aaatattgc  accagagaa  gagggtgga  tacctcgtc  1800
cgttggtaa  aaaactgaa  gtgccttgt  gggacttct  ttggattta  aacgggatt  1860
tcaggatgt  agaaatgaa  taccagaag  agcactgta  aaagtctac  ccttcaatt  1920
tgttaggaa  tccatgagt  ctgtcctga  aaattcaga  ggaagttat  gaatattca  1980
caagggtgc  tctgagata  ttctgaaaa  gtgtttcaa  atcttgagt  ctaatggtg  2040
ggcaaaagt  ttcagacca  gggaccgtg  tgatattgt  aaaactgtg  ttgaaccga  2100
ggcatcaga  ggcttgaga  ccatatgtc  tgcattcag  gattttcca  caggagaac  2160
agaaccaga  tgggataat  aaaatgata  tgtcaccgg  cttacatgc  ttgctgttg  2220
ggggattga  gatcctgtg  gacctgagg  gccagatgc  attaaaaag  gtcagaggg  2280
tggaattac  gtgcggatg  tcactggtg  taatattaa  actgctcgg  ccattgcta  2340
caaatgtgg  attttacat  ctggggaag  ttttctgtg  ctagaaggt  aagatttta  2400
cagaagaat  cgaaatgaa  aaggagaga  tgagcaaga  aggatagac  agatttggc  2460
aaaacttcg  gtacttgca  gatcatctc  tactgataa  catacactg  ttaaaggta  2520
aattgacag  actgtctca  accaacgcc  ggttgtagc  gtaactggt  atggtacaa  2580
tgatggccc  gcactaaag  aagcagatg  tggatttgc  atgggtatt  ctggaactg  2640
tgtagctaa  gaagcatcc  atattattc  cacagatga  aactttaca  gcattgtta  2700
agcagttat  tggggacga  atgtctatg  cagcatctc  aaattcctt  agttccaac  2760
tactgttaa  gtagtagca  tgattgttg  ttttacggg  gcctgcatt  ctcaagact  2820
accgcttaa  gctgtgcag  tgctgtggg  aaacctcat  atggataca  tcgcttccc  2880
ggctctggc  acggaacca  ccactgagt  tctcttgct  cggaaacct  atggtagaa  2940
taagcctct  atctcacgt  caatgatga  gaatatttt  ggtcatgca  tctatcaac  3000
tgtagtagt  tttacactc  tatttgctg  agaaaagtt  tttgacatt  atagtggaa  3060
aaatgctcc  ttgcatgct  ctccttcag  acattatac  attgttttt  atacctttg  3120
gctgatgca  cttttcaac  aaataaatg  ccggaaaat  catggtgaa  gaaatgtat  3180
cgaaggaat  tttaacaat  ccatcttct  cacaattgt  ttaggcact  ttgtggtac  3240
gataataat  gtgcagttt  gtggaaaac  tttcagttg  tcagaactt  caatagaac  3300
gtggctatg  tcaatattc  taggaatgg  aacattact  tggggccag  ttatttcaa  3360
aattccaac  agccgttta  aattcctca  agaagctgg  catggaaca  aaaaggaag  3420
aatacctga  gaggaatta  cagaggatg  tgaagagat  gatcacgct  aaagggagt  3480
gcggcgtgg  caaatcttg  ggtttagag  tctgaacag  atccaaaca  agattcgag  3540
ggtgaatgc  tttcgtagt  ctttatatg  agggttaga  aaaccggaa  caagaagtt  3600
gattcacaa  tttatgaca  atcctgagt  taggataga  gattcagag  ctcatatcc  3660
ccttattga  gacactgat  ccgaagatg  tgctcctac  aaacgtaac  ccagtcctc  3720
accctctcc  aacaaaaat  acaatgctg  tgacagtgg  attcacctt  caatagaaa  3780
gaacaagtc  gctacctct  catccccag  aagcccact  catagtttg  aaacatcac  3840
ctgattgta  gctgaatgt  aacacacta  ctgcattgt  aagaaacaa  ttgaaactg  3900
gtcttttca  atattgtga  ggacaagct  gtattcttg  ctttggact  caacagaag  3960
cacacttgt  cgaatgtag  tttattttt  taaaaaaaa  aaagcaaag  tttctgcca  4020
actgagggt  ctttttggg  ggtgggaga  atgaactga  agataaaca  taactcagc  4080
taagtgacc  gtggatcat  agtagtacc  aagcatggt  ctgaacagt  tattagcag  4140
gctttagtt  atctcagtc  tggatggga  agagaggga  gagtaaaac  gggcaagac  4200
aagagccct  gatcgttga  ttgatagtt  aatttctgc  gttggctgt  aataatttg  4260
attatttat  tttataaat  atacagatc  gtttacaag  tttgtagat  ctttttttg  4320
tcctgttca  agatgggaa  cttccttat  actgatgca  agaaaaatt  gtccttcaa  4380
tactgctgt  ttttcagg  4398



<210> 2805
<211> 1258
<212> PRT
<213> Homo sapiens
<308> P20020
<400> 2805

Met Gly Asp Met Ala Asn Asn Ser Val Ala Tyr Ser Gly Val Lys Asn 
  1               5                  10                  15
Ser Leu Lys Glu Ala Asn His Asp Gly Asp Phe Gly Ile Thr Leu Ala 
             20                  25                  30
Glu Leu Arg Ala Leu Met Glu Leu Arg Ser Thr Asp Ala Leu Arg Lys 
         35                  40                  45
Ile Gln Glu Ser Tyr Gly Asp Val Tyr Gly Ile Cys Thr Lys Leu Lys 
     50                  55                  60
Thr Ser Pro Asn Glu Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Arg 
 65                  70                  75                  80
Arg Glu Ala Val Phe Gly Lys Asn Phe Ile Pro Pro Lys Lys Pro Lys 
                 85                  90                  95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
             100                105                110
Ile Leu Glu Ile Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Gln 
         115                120                125
Pro Pro Glu Gly Asp Asn Ala Leu Cys Gly Glu Val Ser Val Gly Glu 
     130                135                140
Glu Glu Gly Glu Gly Glu Thr Gly Trp Ile Glu Gly Ala Ala Ile Leu 
 145                150                155                160
Leu Ser Val Val Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser 
                 165                170                175
Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln 
             180                185                190
Lys Phe Thr Val Ile Arg Gly Gly Gln Val Ile Gln Ile Pro Val Ala 
         195                200                205
Asp Ile Thr Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu 
     210                215                220
Pro Ala Asp Gly Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu 
 225                230                235                240
Ser Ser Leu Thr Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys 
                 245                250                255
Asp Pro Leu Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg 
             260                265                270
Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe 
         275                280                285
Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Glu Lys 
     290                295                300
Lys Lys Glu Lys Lys Asn Lys Lys Gln Asp Gly Ala Ile Glu Asn Arg 
 305                310                315                320
Asn Lys Ala Lys Ala Gln Asp Gly Ala Ala Met Glu Met Gln Pro Leu 
                 325                330                335
Lys Ser Glu Glu Gly Gly Asp Gly Asp Glu Lys Asp Lys Lys Lys Ala 
             340                345                350
Asn Leu Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys 
         355                360                365
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Leu Met Ser Ala Ile Thr 
     370                375                380
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Asp Thr Phe Trp Val Gln 
 385                390                395                400
Lys Arg Pro Trp Leu Ala Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe 
                 405                410                415
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro 
             420                425                430
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys 
         435                440                445
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu 
     450                455                460
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu 
 465                470                475                480
Thr Met Asn Arg Met Thr Val Val Gln Ala Tyr Ile Asn Glu Lys His 
                 485                490                495
Tyr Lys Lys Val Pro Glu Pro Glu Ala Ile Pro Pro Asn Ile Leu Ser 
             500                505                510
Tyr Leu Val Thr Gly Ile Ser Val Asn Cys Ala Tyr Thr Ser Lys Ile 
         515                520                525
Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro Arg His Val Gly Asn Lys 
     530                535                540
Thr Glu Cys Ala Leu Leu Gly Leu Leu Leu Asp Leu Lys Arg Asp Tyr 
 545                550                555                560
Gln Asp Val Arg Asn Glu Ile Pro Glu Glu Ala Leu Tyr Lys Val Tyr 
                 565                570                575
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Leu Lys Asn Ser 
             580                585                590
Asp Gly Ser Tyr Arg Ile Phe Ser Lys Gly Ala Ser Glu Ile Ile Leu 
         595                600                605
Lys Lys Cys Phe Lys Ile Leu Ser Ala Asn Gly Glu Ala Lys Val Phe 
     610                615                620
Arg Pro Arg Asp Arg Asp Asp Ile Val Lys Thr Val Ile Glu Pro Met 
 625                630                635                640
Ala Ser Glu Gly Leu Arg Thr Ile Cys Leu Ala Phe Arg Asp Phe Pro 
                 645                650                655
Ala Gly Glu Pro Glu Pro Glu Trp Asp Asn Glu Asn Asp Ile Val Thr 
             660                665                670
Gly Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro 
         675                680                685
Glu Val Pro Asp Ala Ile Lys Lys Cys Gln Arg Ala Gly Ile Thr Val 
     690                695                700
Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Thr 
 705                710                715                720
Lys Cys Gly Ile Leu His Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly 
                 725                730                735
Lys Asp Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln 
             740                745                750
Glu Arg Ile Asp Lys Ile Trp Pro Lys Leu Arg Val Leu Ala Arg Ser 
         755                760                765
Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr 
     770                775                780
Val Ser Asp Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn 
 785                790                795                800
Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile 
                 805                810                815
Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp 
             820                825                830
Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val 
         835                840                845
Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val 
     850                855                860
Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser 
 865                870                875                880
Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr 
                 885                890                895
Leu Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu 
             900                905                910
Leu Arg Lys Pro Tyr Gly Arg Asn Lys Pro Leu Ile Ser Arg Thr Met 
         915                920                925
Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu Val Val Val Phe 
     930                935                940
Thr Leu Leu Phe Ala Gly Glu Lys Phe Phe Asp Ile Asp Ser Gly Arg 
 945                950                955                960
Asn Ala Pro Leu His Ala Pro Pro Ser Glu His Tyr Thr Ile Val Phe 
                 965                970                975
Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys 
             980                985                990
Ile His Gly Glu Arg Asn Val Phe Glu Gly Ile Phe Asn Asn Ala Ile 
         995                1000                1005
Phe Cys Thr Ile Val Leu Gly Thr Phe Val Val Gln Ile Ile Ile Val 
     1010                1015                1020
Gln Phe Gly Gly Lys Pro Phe Ser Cys Ser Glu Leu Ser Ile Glu Gln 
 1025                1030                1035                1040
Trp Leu Trp Ser Ile Phe Leu Gly Met Gly Thr Leu Leu Trp Gly Gln 
                 1045                1050                1055
Leu Ile Ser Thr Ile Pro Thr Ser Arg Leu Lys Phe Leu Lys Glu Ala 
             1060                1065                1070
Gly His Gly Thr Gln Lys Glu Glu Ile Pro Glu Glu Glu Leu Ala Glu 
         1075                1080                1085
Asp Val Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln 
     1090                1095                1100
Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Asp Val 
 1105                1110                1115                1120
Val Asn Ala Phe Gln Ser Gly Ser Ser Ile Gln Gly Ala Leu Arg Arg 
                 1125                1130                1135
Gln Pro Ser Ile Ala Ser Gln His His Asp Val Thr Asn Ile Ser Thr 
             1140                1145                1150
Pro Thr His Ile Arg Val Val Asn Ala Phe Arg Ser Ser Leu Tyr Glu 
         1155                1160                1165
Gly Leu Glu Lys Pro Glu Ser Arg Ser Ser Ile His Asn Phe Met Thr 
     1170                1175                1180
His Pro Glu Phe Arg Ile Glu Asp Ser Glu Pro His Ile Pro Leu Ile 
 1185                1190                1195                1200
Asp Asp Thr Asp Ala Glu Asp Asp Ala Pro Thr Lys Arg Asn Ser Ser 
                 1205                1210                1215
Pro Pro Pro Ser Pro Asn Lys Asn Asn Asn Ala Val Asp Ser Gly Ile 
             1220                1225                1230
His Leu Thr Ile Glu Met Asn Lys Ser Ala Thr Ser Ser Ser Pro Gly 
         1235                1240                1245
Ser Pro Leu His Ser Leu Glu Thr Ser Leu 
     1250                1255



<210> 2806
<211> 258
<212> DNA
<213> Rattus norvegicus
<308> L05557
<400> 2806

ccctcccct  ccccaaccc  cctccaaat  ccctcggaa  ggcccagca  acttctgac  60
aaagtgttt  ccttgcaga  ccgcgtcgt  aaggcgttc  gtagctctc  ctatgaagg  120
ttagaaaaa  ccgagtctc  aacctccat  cataacttc  tggctcatc  tgaattccg  180
atcgaagat  cccagcccc  catccccct  atcgatgac  ccgacctgg  agaagatgc  240
gcgctcaag  agaactcg  258



<210> 2807
<211> 1243
<212> PRT
<213> Rattus norvegicus
<308> AAB60703
<400> 2807

Met Gly Asp Met Thr Asn Ser Asp Phe Tyr Ser Lys Asn Gln Arg Asn 
  1               5                  10                  15
Glu Ser Ser His Gly Gly Glu Phe Gly Cys Ser Met Glu Glu Leu Arg 
             20                  25                  30
Ser Leu Met Glu Leu Arg Gly Thr Glu Ala Val Val Lys Ile Lys Glu 
         35                  40                  45
Thr Tyr Gly Asp Thr Glu Ser Ile Cys Arg Arg Leu Lys Thr Ser Pro 
     50                  55                  60
Val Glu Gly Leu Pro Gly Thr Ala Pro Asp Leu Glu Lys Arg Lys Gln 
 65                  70                  75                  80
Ile Phe Gly Gln Asn Phe Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu 
                 85                  90                  95
Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu 
             100                105                110
Ile Ala Ala Ile Ile Ser Leu Gly Leu Ser Phe Tyr His Pro Pro Gly 
         115                120                125
Glu Ser Asn Glu Gly Cys Ala Thr Ala Gln Gly Gly Ala Glu Asp Glu 
     130                135                140
Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Leu Ser 
 145                150                155                160
Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu 
                 165                170                175
Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln Lys Phe 
             180                185                190
Thr Val Val Arg Ala Gly Gln Val Val Gln Ile Pro Val Ala Glu Ile 
         195                200                205
Val Val Gly Asp Ile Ala Gln Ile Lys Tyr Gly Asp Leu Leu Pro Ala 
     210                215                220
Asp Gly Leu Phe Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser 
 225                230                235                240
Leu Thr Gly Glu Ser Asp Gln Val Arg Lys Ser Val Asp Lys Asp Pro 
                 245                250                255
Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Val 
             260                265                270
Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe Thr Leu 
         275                280                285
Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys Lys Gly Val 
     290                295                300
Lys Lys Gly Asp Gly Leu Gln Leu Pro Ala Ala Asp Gly Ala Ala Pro 
 305                310                315                320
Ala Asn Ala Ala Gly Ser Ala Asn Ala Ser Leu Val Asn Gly Lys Met 
                 325                330                335
Gln Asp Gly Ser Ala Asp Ser Ser Gln Ser Lys Ala Lys Gln Gln Asp 
             340                345                350
Gly Ala Ala Ala Met Glu Met Gln Pro Leu Lys Ser Ala Glu Gly Gly 
         355                360                365
Asp Ala Asp Asp Lys Lys Lys Ala Asn Met His Lys Lys Glu Lys Ser 
     370                375                380
Val Leu Gln Gly Lys Leu Thr Lys Leu Ala Val Gln Ile Gly Lys Ala 
 385                390                395                400
Gly Leu Val Met Ser Ala Ile Thr Val Ile Ile Leu Val Leu Tyr Phe 
                 405                410                415
Thr Val Asp Thr Phe Val Val Asn Lys Lys Pro Trp Leu Thr Glu Cys 
             420                425                430
Thr Pro Val Tyr Val Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Val 
         435                440                445
Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr 
     450                455                460
Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu 
 465                470                475                480
Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile 
                 485                490                495
Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Arg Met Thr Val Val 
             500                505                510
Gln Ala Tyr Val Gly Asp Val His Tyr Lys Glu Ile Pro Asp Pro Ser 
         515                520                525
Ser Ile Asn Ala Lys Thr Leu Glu Leu Leu Val Asn Ala Ile Ala Ile 
     530                535                540
Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro Pro Glu Lys Glu Gly Ala 
 545                550                555                560
Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Gly Leu Leu Gly Phe 
                 565                570                575
Val Leu Asp Leu Arg Gln Asp Tyr Glu Pro Val Arg Ser Gln Met Pro 
             580                585                590
Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser 
         595                600                605
Met Ser Thr Val Ile Lys Met Pro Asp Glu Ser Phe Arg Met Tyr Ser 
     610                615                620
Lys Gly Ala Ser Glu Ile Val Leu Lys Lys Cys Cys Lys Ile Leu Ser 
 625                630                635                640
Gly Ala Gly Glu Pro Arg Val Phe Arg Pro Arg Asp Arg Asp Glu Met 
                 645                650                655
Val Lys Lys Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile 
             660                665                670
Cys Val Ala Tyr Arg Asp Phe Pro Ser Ser Pro Glu Pro Asp Trp Asp 
         675                680                685
Asn Glu Asn Asp Ile Leu Asn Glu Leu Thr Cys Ile Cys Val Val Gly 
     690                695                700
Ile Glu Asp Pro Val Arg Pro Glu Val Pro Glu Ala Ile Arg Lys Cys 
 705                710                715                720
Gln Arg Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn 
                 725                730                735
Thr Ala Arg Ala Ile Ala Ile Lys Cys Gly Ile Ile His Pro Gly Glu 
             740                745                750
Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Arg Ile Arg Asn 
         755                760                765
Glu Lys Gly Glu Ile Glu Gln Glu Arg Ile Asp Lys Ile Trp Pro Lys 
     770                775                780
Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val 
 785                790                795                800
Lys Gly Ile Ile Asp Ser Thr His Thr Glu Gln Arg Gln Val Val Ala 
                 805                810                815
Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp 
             820                825                830
Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala 
         835                840                845
Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Ser Ser Ile Val Lys Ala 
     850                855                860
Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln 
 865                870                875                880
Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly 
                 885                890                895
Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp 
             900                905                910
Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu 
         915                920                925
Pro Pro Thr Glu Thr Leu Leu Leu Arg Lys Pro Tyr Gly Arg Asn Lys 
     930                935                940
Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Val 
 945                950                955                960
Tyr Gln Leu Thr Leu Ile Phe Thr Leu Leu Phe Val Gly Glu Lys Met 
                 965                970                975
Phe Gln Ile Asp Ser Gly Arg Asn Ala Pro Leu His Ser Pro Pro Ser 
             980                985                990
Glu His Tyr Thr Ile Ile Phe Asn Thr Phe Val Met Met Gln Leu Phe 
         995                1000                1005
Asn Glu Ile Asn Ala Arg Lys Ile His Gly Glu Arg Asn Val Phe Asp 
     1010                1015                1020
Gly Ile Phe Arg Asn Pro Ile Phe Cys Thr Ile Val Leu Gly Thr Phe 
 1025                1030                1035                1040
Ala Ile Gln Ile Val Ile Val Gln Phe Gly Gly Lys Pro Phe Ser Cys 
                 1045                1050                1055
Ser Pro Leu Gln Leu Asp Gln Trp Met Trp Cys Ile Phe Ile Gly Leu 
             1060                1065                1070
Gly Glu Leu Val Trp Gly Gln Val Ile Ala Thr Ile Pro Thr Ser Arg 
         1075                1080                1085
Leu Lys Phe Leu Lys Glu Ala Gly Arg Leu Thr Gln Lys Glu Glu Ile 
     1090                1095                1100
Pro Glu Glu Glu Leu Asn Glu Asp Val Glu Glu Ile Asp His Ala Glu 
 1105                1110                1115                1120
Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg 
                 1125                1130                1135
Ile Gln Thr Gln Ile Arg Val Val Lys Ala Phe Arg Ser Ser Leu Tyr 
             1140                1145                1150
Glu Gly Leu Glu Lys Pro Glu Ser Arg Thr Ser Ile His Asn Phe Met 
         1155                1160                1165
Ala His Pro Glu Phe Arg Ile Glu Asp Ser Gln Pro His Ile Pro Leu 
     1170                1175                1180
Ile Asp Asp Thr Asp Leu Glu Glu Asp Ala Ala Leu Lys Gln Asn Ser 
 1185                1190                1195                1200
Ser Pro Pro Ser Ser Leu Asn Lys Asn Asn Ser Ala Ile Asp Ser Gly 
                 1205                1210                1215
Ile Asn Leu Thr Thr Asp Thr Ser Lys Ser Ala Thr Ser Ser Ser Pro 
             1220                1225                1230
Gly Ser Pro Ile His Ser Leu Glu Thr Ser Leu 
         1235                1240



<210> 2808
<211> 4857
<212> DNA
<213> Homo sapiens
<308> XM_052353
<400> 2808

gagccacca  ccctgacca  gtagatgcc  gttccaggg  gcagcatgg  ccccactga  60
tggagactc  tgggtctac  gccctgagc  cctccggcc  ctggacctc  tcccacacc  120
gaggacacc  cttggagct  accaccact  tcaccagcc  gcctcggcc  cccccaccc  180
ccgggaccc  gagtcggcc  cctggtgcc  cagctgacc  gtgagggtg  gctgaggac  240
gccacaagc  gccatcacc  ggcagcctc  tgtccagcg  tgacccttg  gcccagccc  300
agcaaggac  gcagcaaac  tgggtgaca  gaccaacag  gacttttac  ccaaaaacc  360
aagaaatga  tcgagccat  ggggcgagt  cgggtgcac  atggaggag  tccgctccc  420
catggagct  cggggcact  aggctgtgg  caagatcaa  gagacttat  gggacaccg  480
agccatctg  cggcgcctc  aaacctcac  tgttgaagg  ttgccgggc  ccgctccag  540
cctggaaaa  agaaagcaa  tttttgggc  aaactttat  cctccaaag  agccaaaaa  600
cttcctgca  ctcgtgtgg  aggcgctgc  ggacgtgac  ctcatcatc  tggagattg  660
cgccatcat  tccctgggg  tgtccttct  ccacccgcc  ggcgagggc  acgaaggat  720
tgcgacggc  cagggtggg  cagaggatg  aggagaggc  gaggcaggt  ggatcgagg  780
ggccgccat  ctcctctca  ttatctgtg  ggtcctggt  acggccttc  atgactgga  840
caaagagaa  cagttccgg  gcctgcaga  ccgcatcga  caggaacag  aatttaccg  900
ggtccgggc  ggccaggtg  tccagatcc  tgtggctga  atcgtggtt  gggacatag  960
ccaggtcaa  tatggtgac  tcctccctg  cgacggcct  ttcatccag  gcaatgacc  1020
caagattga  gaaagctcc  taactggag  gtctgacca  gtgcgcaag  ccgtggaca  1080
ggaccccat  ctgctgtca  gaacccacg  gatggaggg  tcaggacgg  tgttggtga  1140
tgctgtggg  gtgaactct  agactggca  catctttac  ctcctgggg  ctggtggtg  1200
agaggaaga  aagaaagac  aaaaaggtg  gaagaaggg  gatggcctt  agctaccag  1260
agcagacgg  gcggcagct  caaatgctg  agatagtgc  aatgccagc  tagtcaatg  1320
taaaatgca  gatggcaat  tggacgcca  ccagagcaa  gccaaacaa  aggacgggg  1380
agccgccat  gagatgcag  ccctcaaga  tgccgaggg  ggcgacgct  acgacagga  1440
gaaggccag  atgcacaag  aggagaagt  cgtgctgca  ggcaagctc  ccaagctgg  1500
tgtgcagat  gggaaggcg  gcttggtga  gtcagccat  acggtgatc  tcctggtgc  1560
ctacttcac  gtggacacc  tcgtggtca  caagaagcc  tggctgcct  agtgcacgc  1620
cgtctacgt  cagtacttt  tcaagttct  catcattgg  gtgacggtg  tggtggtcg  1680
cgtgcccga  gggctccct  tggccgtca  catctcgtt  gcctattcg  tgaagaaaa  1740
gatgaagga  aacaacctg  tacgccacc  ggatgcctg  gagaccatg  gcaatgcca  1800
agccatctg  tcagacaag  caggcacgc  gaccaccaa  cgcatgaca  tggtacagg  1860
ctatgtcgg  gacgtccac  ataaagaga  ccccgaccc  agctccatc  acaccaaga  1920
catggagct  ctgatcaat  ccatcgcca  caacagcgc  tacaccacc  agattctgc  1980
cccagagaa  gagggcgcc  tgcctcggc  ggtgggcaa  aagacggag  gcggcctgc  2040
gggcttcgt  ctggacctg  agcaggact  cgagcccgt  cgcagccag  tgccagagg  2100
gaagttgta  aaagtgtac  ccttcaact  cgtgcgcaa  tccatgagc  ctgtcatca  2160
gctgcccga  gagagcttc  gcatgtaca  caagggggc  tctgagatc  tgctcaaga  2220
gtgctgcaa  atcctcaat  gggcgggag  gcctcgtgt  ttccggccc  gcgaccggg  2280
cgagatggt  aagaaggtg  ttgagccca  ggcttgcga  gggctccgc  ctatctgcg  2340
ggcctaccg  gacttcccc  gcagcccgg  gccggactg  gacaatgag  atgacatcc  2400
caacgaact  acctgcatc  gcgtggtgg  catcgagga  ccggtgcgg  cagaggtcc  2460
agaagccat  cgcaagtgc  agcgggcag  catcacggt  cgcatggtc  ctggcgaca  2520
tatcaacac  gctcgggcc  tcgccatca  gtgtggcat  atccatcct  gggaggact  2580
tctgtgcct  gagggcaag  agttcaaca  gaggatccg  aacgagaag  gggagattg  2640
gcaggagcg  attgacaag  tctggccaa  gctgcgggt  ctggctcgc  cctccccaa  2700
ggacaagca  accctggtt  aaggcatca  cgacagcac  cacactgag  agcggcagg  2760
ggtggccgt  acgggggac  ggaccaacg  cgggcctgc  ctcaagaag  ccgacgtgg  2820
cttcgccat  ggcatcgca  gcactgacg  ggccaagga  gcctcagac  tcatcctga  2880
agacgacaa  ttcagcagc  tcgtcaagg  agtgatgtg  ggccgcaac  tctatgaca  2940
catctccaa  ttcttgcag  tccagctca  cgtcaacgt  gtggccgtg  ttgtggcct  3000
cacaggcgc  tgcatcacg  aggactccc  tctgaaggc  gtgcagatg  tctgggtga  3060
cctcatcat  gacacgttt  cctcgctgg  actggccac  gagccgccc  cggagaccc  3120
gctgctgag  aagccgtac  gccgcaaca  gccgctcat  tccaggacc  tgatgaaga  3180
catcctggg  catgctgtc  accagcttg  cctcatctt  accctgctc  ttgttggcg  3240
gaagatgtt  cagatcgac  gcgggagga  cgcgcccct  cattcgcca  cctcagaac  3300
ttacaccat  atcttcaac  ccttcgtca  gatgcagct  ttcaacgag  tcaacgccc  3360
caagatcca  ggcgagcgc  atgtctttg  cggcatctt  cggaacccc  tcttctgca  3420
catcgtgct  ggcaccttt  ccatccaga  agtgatcgt  cagtttgga  ggaagccat  3480
cagctgctc  ccactgcag  tggaccagt  gatgtggtg  atattcatt  ggttaggag  3540
gctcgtttg  ggccaggtc  tcgccacca  cccgaccag  agactcaag  tcctcaagg  3600
ggcaggcag  ctcacacag  aggaggaga  cccggagga  gagctcaac  aggacgtgg  3660
ggagatcga  cacgcagag  gggagctgc  gcggggcca  atcctgtgg  tccgaggcc  3720
gaatcggat  cagacacag  tccgcgtcg  gaaggcgtt  cgtagctct  tctatgaag  3780
tttagaaaa  cctgaatct  gaacctcca  ccataactt  atggctcat  ctgaattcc  3840
gatcgaaga  tcccagccc  acatccccc  cattgatga  accgacctg  aagaagatg  3900
cgcgctcaa  cagaactcg  gcccgccgt  atccctcaa  aagaacaac  gcgccatcg  3960
cagtgggat  aacctgacg  ccgacacaa  caaatcagc  acctcttca  gtccaggga  4020
ccccatcca  agcctggag  cgtcgcttt  gctgaggac  ctctcgcct  cccgcccgc  4080
ctcatggac  ccgctgcca  ccgctttcc  ggcacccat  catccaggc  cccaactca  4140
ccaagcagc  acgagcaac  atcggaaac  aaatactgg  gagaaaacc  acgtttcca  4200
ccacagacc  tttctctgg  tgcgatgct  tttgaactc  ttttcactt  aaggcaagg  4260
gcgggatct  cactggggg  ttacgggag  gagcggttt  cccaaaaca  gcccttcct  4320
gctcccacc  agacatgga  cagccatgc  cccgcccag  caccacgtc  cccgcatga  4380
tgtactgta  actttcaat  ctccccttg  ttggttttt  ggggttggg  aggggtttt  4440
gtttgtttg  ttgttttct  aggcgggaa  tgcaaacag  ctcttttct  agactattt  4500
tccaatcca  tggtctgtg  gtttttgaa  tgcttgcac  gcatggtct  agttgtata  4560
attaattta  taacttttt  aaattgcag  gcttaactc  cctagtaga  ttgcaccaa  4620
ggaaccgaa  aacttcata  acactcaca  ggttatatc  atttctttg  atctatatc  4680
acgtatact  ttccgagac  gtatacgtc  atatagata  gtagatata  atatatata  4740
ataaatata  atacatgga  atataaagt  tctttgccg  catgttgcc  tgtttccgc  4800
taaattgct  tattttaac  tatttatgt  ctaaaagaa  aatgtaatt  gtttaca  4857



<210> 2809
<211> 1243
<212> PRT
<213> Homo sapiens
<308> XP_052353
<400> 2809

Met Gly Asp Met Thr Asn Ser Asp Phe Tyr Ser Lys Asn Gln Arg Asn 
  1               5                  10                  15
Glu Ser Ser His Gly Gly Glu Phe Gly Cys Thr Met Glu Glu Leu Arg 
             20                  25                  30
Ser Leu Met Glu Leu Arg Gly Thr Glu Ala Val Val Lys Ile Lys Glu 
         35                  40                  45
Thr Tyr Gly Asp Thr Glu Ala Ile Cys Arg Arg Leu Lys Thr Ser Pro 
     50                  55                  60
Val Glu Gly Leu Pro Gly Thr Ala Pro Asp Leu Glu Lys Arg Lys Gln 
 65                  70                  75                  80
Ile Phe Gly Gln Asn Phe Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu 
                 85                  90                  95
Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu 
             100                105                110
Ile Ala Ala Ile Ile Ser Leu Gly Leu Ser Phe Tyr His Pro Pro Gly 
         115                120                125
Glu Gly Asn Glu Gly Cys Ala Thr Ala Gln Gly Gly Ala Glu Asp Glu 
     130                135                140
Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Leu Ser 
 145                150                155                160
Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu 
                 165                170                175
Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln Lys Phe 
             180                185                190
Thr Val Val Arg Ala Gly Gln Val Val Gln Ile Pro Val Ala Glu Ile 
         195                200                205
Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala 
     210                215                220
Asp Gly Leu Phe Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser 
 225                230                235                240
Leu Thr Gly Glu Ser Asp Gln Val Arg Lys Ser Val Asp Lys Asp Pro 
                 245                250                255
Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Leu 
             260                265                270
Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe Thr Leu 
         275                280                285
Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys Lys Gly Val 
     290                295                300
Lys Lys Gly Asp Gly Leu Gln Leu Pro Ala Ala Asp Gly Ala Ala Ala 
 305                310                315                320
Ser Asn Ala Ala Asp Ser Ala Asn Ala Ser Leu Val Asn Gly Lys Met 
                 325                330                335
Gln Asp Gly Asn Val Asp Ala Ser Gln Ser Lys Ala Lys Gln Gln Asp 
             340                345                350
Gly Ala Ala Ala Met Glu Met Gln Pro Leu Lys Ser Ala Glu Gly Gly 
         355                360                365
Asp Ala Asp Asp Arg Lys Lys Ala Ser Met His Lys Lys Glu Lys Ser 
     370                375                380
Val Leu Gln Gly Lys Leu Thr Lys Leu Ala Val Gln Ile Gly Lys Ala 
 385                390                395                400
Gly Leu Val Met Ser Ala Ile Thr Val Ile Ile Leu Val Leu Tyr Phe 
                 405                410                415
Thr Val Asp Thr Phe Val Val Asn Lys Lys Pro Trp Leu Pro Glu Cys 
             420                425                430
Thr Pro Val Tyr Val Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Val 
         435                440                445
Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr 
     450                455                460
Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu 
 465                470                475                480
Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile 
                 485                490                495
Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Arg Met Thr Val Val 
             500                505                510
Gln Ala Tyr Val Gly Asp Val His Tyr Lys Glu Ile Pro Asp Pro Ser 
         515                520                525
Ser Ile Asn Thr Lys Thr Met Glu Leu Leu Ile Asn Ala Ile Ala Ile 
     530                535                540
Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro Pro Glu Lys Glu Gly Ala 
 545                550                555                560
Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Gly Leu Leu Gly Phe 
                 565                570                575
Val Leu Asp Leu Lys Gln Asp Tyr Glu Pro Val Arg Ser Gln Met Pro 
             580                585                590
Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser 
         595                600                605
Met Ser Thr Val Ile Lys Leu Pro Asp Glu Ser Phe Arg Met Tyr Ser 
     610                615                620
Lys Gly Ala Ser Glu Ile Val Leu Lys Lys Cys Cys Lys Ile Leu Asn 
 625                630                635                640
Gly Ala Gly Glu Pro Arg Val Phe Arg Pro Arg Asp Arg Asp Glu Met 
                 645                650                655
Val Lys Lys Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile 
             660                665                670
Cys Val Ala Tyr Arg Asp Phe Pro Ser Ser Pro Glu Pro Asp Trp Asp 
         675                680                685
Asn Glu Asn Asp Ile Leu Asn Glu Leu Thr Cys Ile Cys Val Val Gly 
     690                695                700
Ile Glu Asp Pro Val Arg Pro Glu Val Pro Glu Ala Ile Arg Lys Cys 
 705                710                715                720
Gln Arg Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn 
                 725                730                735
Thr Ala Arg Ala Ile Ala Ile Lys Cys Gly Ile Ile His Pro Gly Glu 
             740                745                750
Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Arg Ile Arg Asn 
         755                760                765
Glu Lys Gly Glu Ile Glu Gln Glu Arg Ile Asp Lys Ile Trp Pro Lys 
     770                775                780
Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val 
 785                790                795                800
Lys Gly Ile Ile Asp Ser Thr His Thr Glu Gln Arg Gln Val Val Ala 
                 805                810                815
Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp 
             820                825                830
Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala 
         835                840                845
Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Ser Ser Ile Val Lys Ala 
     850                855                860
Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln 
 865                870                875                880
Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly 
                 885                890                895
Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp 
             900                905                910
Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu 
         915                920                925
Pro Pro Thr Glu Thr Leu Leu Leu Arg Lys Pro Tyr Gly Arg Asn Lys 
     930                935                940
Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Val 
 945                950                955                960
Tyr Gln Leu Ala Leu Ile Phe Thr Leu Leu Phe Val Gly Glu Lys Met 
                 965                970                975
Phe Gln Ile Asp Ser Gly Arg Asn Ala Pro Leu His Ser Pro Pro Ser 
             980                985                990
Glu His Tyr Thr Ile Ile Phe Asn Thr Phe Val Met Met Gln Leu Phe 
         995                1000                1005
Asn Glu Ile Asn Ala Arg Lys Ile His Gly Glu Arg Asn Val Phe Asp 
     1010                1015                1020
Gly Ile Phe Arg Asn Pro Ile Phe Cys Thr Ile Val Leu Gly Thr Phe 
 1025                1030                1035                1040
Ala Ile Gln Ile Val Ile Val Gln Phe Gly Gly Lys Pro Phe Ser Cys 
                 1045                1050                1055
Ser Pro Leu Gln Leu Asp Gln Trp Met Trp Cys Ile Phe Ile Gly Leu 
             1060                1065                1070
Gly Glu Leu Val Trp Gly Gln Val Ile Ala Thr Ile Pro Thr Ser Arg 
         1075                1080                1085
Leu Lys Phe Leu Lys Glu Ala Gly Arg Leu Thr Gln Lys Glu Glu Ile 
     1090                1095                1100
Pro Glu Glu Glu Leu Asn Glu Asp Val Glu Glu Ile Asp His Ala Glu 
 1105                1110                1115                1120
Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg 
                 1125                1130                1135
Ile Gln Thr Gln Ile Arg Val Val Lys Ala Phe Arg Ser Ser Leu Tyr 
             1140                1145                1150
Glu Gly Leu Glu Lys Pro Glu Ser Arg Thr Ser Ile His Asn Phe Met 
         1155                1160                1165
Ala His Pro Glu Phe Arg Ile Glu Asp Ser Gln Pro His Ile Pro Leu 
     1170                1175                1180
Ile Asp Asp Thr Asp Leu Glu Glu Asp Ala Ala Leu Lys Gln Asn Ser 
 1185                1190                1195                1200
Ser Pro Pro Ser Ser Leu Asn Lys Asn Asn Ser Ala Ile Asp Ser Gly 
                 1205                1210                1215
Ile Asn Leu Thr Thr Asp Thr Ser Lys Ser Ala Thr Ser Ser Ser Pro 
             1220                1225                1230
Gly Ser Pro Ile His Ser Leu Glu Thr Ser Leu 
         1235                1240



<210> 2810
<211> 2146
<212> DNA
<213> Rattus norvegicus
<308> L07073
<400> 2810

cggacccgg  accgaatca  tgactcgcc  aggtgtcgg  aaaatgatc  acagtctat  60
tctcatcaa  tgttctggc  acatatttc  agaaaaaca  tggaagagc  ttgtaagcc  120
atctgtgtg  gactatttc  ttgaagctc  ggagaaagc  gctgatgtt  aaaatgtac  180
aactgtcat  tcaacacct  accactacc  cattagtat  taccgggat  agctcttct  240
tgtgtctgt  atacagact  aagtgccac  tctctttgt  attgagttt  tgcatcgag  300
tgctgacac  tttcaggac  actttggtg  gtgttcaga  gctgcaatt  aggataatg  360
ggtcatagt  tatgagctc  tggaagaaa  gttagacaa  ggattccca  tggctaccg  420
atctaacat  ctgaaagaa  tgattaaac  accaacaat  ctacgttct  tcgtcaatt  480
tattacagg  agtagtaat  ttggggaca  gctccccac  gggcagctg  ccaacatcc  540
atggcgtcg  gcaggtgta  agtacacca  caatgaagc  tactttgat  tagtcgaag  600
gatagatgc  attatagat  aatcaggat  tacagtctt  gcagaaatt  aaggtgtca  660
tgatgcttg  attaagctg  ctggaatgc  tgatctctc  ctctctttc  tgaacccaa  720
gcttctaga  gatgtcagc  tccacccat  catccggtt  aaacgctgg  aatctgaga  780
agttttgtc  ttcattcct  ccgatggaa  tttccgact  atatcatac  gcgtcagct  840
acaaaatct  gtggcaatc  cagtgtatg  gaaacataa  atcagcttt  aggaaaaca  900
ctcttgtgg  agatttgat  taacaattg  accaaaaca  aatatggga  aaacgattg  960
aggaatcac  gtgactgtt  acatgccaa  agttgtgct  aatatgaac  tgacaccaa  1020
acaaggcag  tatacattc  atccagtca  caaggtact  gcatgggat  tggggaaaa  1080
tactccaca  aagctccca  gtcttaaag  actggtaaa  ttacagtca  gagcaccca  1140
gccagaaga  aacccaaac  tcaacatac  gttcaagat  cagcagctt  ctatttcag  1200
cttaaaagt  aaccgcttg  acatgtatg  tgagaagta  aagccattt  aaggagtca  1260
gtatatcac  aaggccgga  agttccaag  gaggacatg  gaagaggcc  gacttgctc  1320
agatcagtt  gttttgcaa  tgtcattgc  gtttcttac  attaggtac  aagtgggtg  1380
gaataatat  gagcatctg  gtcaagcta  cctgctaac  aagttgctt  gtaatgatg  1440
aggctcctc  ggagcttta  gctaaggaa  gttttctaa  gacttagct  attttgtat  1500
ttttcactt  ggaaaaggt  taggtgatt  ttttccatg  gggccacca  ctgaatgct  1560
cccatgggt  acagtcaag  cagaaggct  cagtgataa  ctctctcct  aagcaagtg  1620
actggtctc  tcttccagc  ggaactgtc  cagtctatg  ggtgtcagc  gtagccaag  1680
gtcacacct  ctgatctta  ccatctcaa  cagtgtctg  cccaagaga  gagattgcc  1740
ccaccccca  gaagtttac  gaaaactgc  tcttcaagt  tttgcctta  tcagctttt  1800
acttgtgcc  ttaagcaag  actgtagca  aagccactt  cacatggcc  aggcaggga  1860
ccctgcagc  ccatgctcc  ttcctcacc  ggttaacct  gggtattat  ttttttata  1920
ataagattt  tatgtaaag  tcagatttt  atttacaag  ccttgctgc  gtaaatatt  1980
catcaatct  gagccacca  ttcagctgt  agatagcac  gtcaaatca  ttgcatcaa  2040
agggcaaat  ctttattaa  ataatgaaa  ggaacacta  ttctgctgt  aggcacaag  2100
gtctgtgct  ttaaacaaa  tcaagtagt  aaagagaaa  tcaagc  2146



<210> 2811
<211> 418
<212> PRT
<213> Rattus norvegicus
<308> P53676
<400> 2811

Met Ile His Ser Leu Phe Leu Ile Asn Cys Ser Gly Asp Ile Phe Leu 
  1               5                  10                  15
Glu Lys His Trp Lys Ser Val Val Ser Gln Ser Val Cys Asp Tyr Phe 
             20                  25                  30
Phe Glu Ala Gln Glu Lys Ala Ala Asp Val Glu Asn Val Pro Thr Val 
         35                  40                  45
Ile Ser Thr Pro His His Tyr Leu Ile Ser Ile Tyr Arg Asp Lys Leu 
     50                  55                  60
Phe Phe Val Ser Val Ile Gln Thr Glu Val Pro Pro Leu Phe Val Ile 
 65                  70                  75                  80
Glu Phe Leu His Arg Val Ala Asp Thr Phe Gln Asp Tyr Phe Gly Glu 
                 85                  90                  95
Cys Ser Glu Ala Ala Ile Lys Asp Asn Val Val Ile Val Tyr Glu Leu 
             100                105                110
Leu Glu Glu Met Leu Asp Asn Gly Phe Pro Leu Ala Thr Glu Ser Asn 
         115                120                125
Ile Leu Lys Glu Leu Ile Lys Pro Pro Thr Ile Leu Arg Ser Val Val 
     130                135                140
Asn Ser Ile Thr Gly Ser Ser Asn Val Gly Asp Thr Leu Pro Thr Gly 
 145                150                155                160
Gln Leu Ser Asn Ile Pro Trp Arg Arg Ala Gly Val Lys Tyr Thr Asn 
                 165                170                175
Asn Glu Ala Tyr Phe Asp Val Val Glu Glu Ile Asp Ala Ile Ile Asp 
             180                185                190
Lys Ser Gly Ser Thr Val Phe Ala Glu Ile Gln Gly Val Ile Asp Ala 
         195                200                205
Cys Ile Lys Leu Ser Gly Met Pro Asp Leu Ser Leu Ser Phe Met Asn 
     210                215                220
Pro Arg Leu Leu Asp Asp Val Ser Phe His Pro Cys Ile Arg Phe Lys 
 225                230                235                240
Arg Trp Glu Ser Glu Arg Val Leu Ser Phe Ile Pro Pro Asp Gly Asn 
                 245                250                255
Phe Arg Leu Ile Ser Tyr Arg Val Ser Ser Gln Asn Leu Val Ala Ile 
             260                265                270
Pro Val Tyr Val Lys His Asn Ile Ser Phe Lys Glu Asn Ser Ser Cys 
         275                280                285
Gly Arg Phe Asp Ile Thr Ile Gly Pro Lys Gln Asn Met Gly Lys Thr 
     290                295                300
Ile Glu Gly Ile Thr Val Thr Val His Met Pro Lys Val Val Leu Asn 
 305                310                315                320
Met Asn Leu Thr Pro Thr Gln Gly Ser Tyr Thr Phe Asp Pro Val Thr 
                 325                330                335
Lys Val Leu Ala Trp Asp Val Gly Lys Ile Thr Pro Gln Lys Leu Pro 
             340                345                350
Ser Leu Lys Gly Leu Val Asn Leu Gln Ser Gly Ala Pro Lys Pro Glu 
         355                360                365
Glu Asn Pro Asn Leu Asn Ile Gln Phe Lys Ile Gln Gln Leu Ala Ile 
     370                375                380
Ser Gly Leu Lys Val Asn Arg Leu Asp Met Tyr Gly Glu Lys Tyr Lys 
 385                390                395                400
Pro Phe Lys Gly Val Lys Tyr Ile Thr Lys Ala Gly Lys Phe Gln Val 
                 405                410                415
Arg Thr 
             420



<210> 2812
<211> 1348
<212> DNA
<213> Homo sapiens
<308> AF092092
<400> 2812

atgatccac  gtctatttc  cataaactg  tccggtgac  tatttctag  gaagcactg  60
aagagcgtt  tgagccagt  tgtctgtga  tatttcttt  aagctcaag  gaaagctgc  120
gatgttgaa  atgtaccac  tgtcatttc  acacctcac  actacctca  cagtatcta  180
cgggataag  tcttctttg  atctgtcat  cagaccgaa  tgccacctc  ctttgtaat  240
gagttccta  atcgagttg  tgacacttt  caggactac  ttggtgagt  ttcagaggc  300
gcaattaag  ataatgtgg  catagtata  gaactctta  aagaaatgt  agacaatgg  360
tttccactg  ctaccgaat  taacatttt  aaagaattg  ttaaaccac  aacaattct  420
cgctctgtt  tcaactcta  tacaggcag  agtaatgtt  gggacacac  ccccaccgg  480
cagctgtcc  acataccat  gcgtcgggc  ggggtaaag  acacaaaca  tgaagccta  540
tttgatgtt  ttgaagaaa  agacgcaat  atagataaa  caggatcta  agtctttgc  600
gaaattcag  gggtcattg  tgcttgcat  aaactatct  gaatgcctg  tctctccct  660
tctttcatg  accctaggc  tctggatga  gtcagcttt  acccctgca  ccggttcaa  720
cgttgggaa  ctgaaagag  tttgtcatt  attcctcca  atggaaatt  ccgactcat  780
tcataccgt  tcagctcac  aaatctagt  gcaatacca  tgtatgtga  acatagtat  840
agctttaag  agaacagtt  ttgcggcag  tttgatata  caattggac  aaagcagaa  900
atggggaaa  ctattgaag  aattacagt  acagttcac  tgccaaaag  tgtgctgaa  960
atgaacctg  cacccacac  aggcagcta  acatttgat  cagtcacca  ggtactaac  1020
tgggatgtg  gaaaaatta  tccacaaaa  ctcccaagt  ttaaaggac  ggtaaattt  1080
cagtctgga  cccccaaac  agaagagaa  ccgagcctc  acatacagt  taagatcca  1140
cagcttgct  tttcaggct  aaaagtaaa  cgtttggac  tgtatgggg  gaaatataa  1200
ccatttaaa  gagtcaaat  cgtcacgaa  gctggaaag  tccaagtga  gacatgaga  1260
gaggccaaa  ttcctcagg  ccagtttgt  ttccaagtg  cattacgat  tatcactat  1320
aggtaccaa  tgagtggga  tacatatt  1348



<210> 2813
<211> 418
<212> PRT
<213> Homo sapiens
<308> Q9Y2T2
<400> 2813

Met Ile His Ser Leu Phe Leu Ile Asn Cys Ser Gly Asp Ile Phe Leu 
  1               5                  10                  15
Glu Lys His Trp Lys Ser Val Val Ser Gln Ser Val Cys Asp Tyr Phe 
             20                  25                  30
Phe Glu Ala Gln Glu Lys Ala Ala Asp Val Glu Asn Val Pro Pro Val 
         35                  40                  45
Ile Ser Thr Pro His His Tyr Leu Ile Ser Ile Tyr Arg Asp Lys Leu 
     50                  55                  60
Phe Phe Val Ser Val Ile Gln Thr Glu Val Pro Pro Leu Phe Val Ile 
 65                  70                  75                  80
Glu Phe Leu His Arg Val Ala Asp Thr Phe Gln Asp Tyr Phe Gly Glu 
                 85                  90                  95
Cys Ser Glu Ala Ala Ile Lys Asp Asn Val Val Ile Val Tyr Glu Leu 
             100                105                110
Leu Glu Glu Met Leu Asp Asn Gly Phe Pro Leu Ala Thr Glu Ser Asn 
         115                120                125
Ile Leu Lys Glu Leu Ile Lys Pro Pro Thr Ile Leu Arg Ser Val Val 
     130                135                140
Asn Ser Ile Thr Gly Ser Ser Asn Val Gly Asp Thr Leu Pro Thr Gly 
 145                150                155                160
Gln Leu Ser Asn Ile Pro Trp Arg Arg Ala Gly Val Lys Tyr Thr Asn 
                 165                170                175
Asn Glu Ala Tyr Phe Asp Val Val Glu Glu Ile Asp Ala Ile Ile Asp 
             180                185                190
Lys Ser Gly Ser Thr Val Phe Ala Glu Ile Gln Gly Val Ile Asp Ala 
         195                200                205
Cys Ile Lys Leu Ser Gly Met Pro Asp Leu Ser Leu Ser Phe Met Asn 
     210                215                220
Pro Arg Leu Leu Asp Asp Val Ser Phe His Pro Cys Ile Arg Phe Lys 
 225                230                235                240
Arg Trp Glu Ser Glu Arg Val Leu Ser Phe Ile Pro Pro Asp Gly Asn 
                 245                250                255
Phe Arg Leu Ile Ser Tyr Arg Val Ser Ser Gln Asn Leu Val Ala Ile 
             260                265                270
Pro Val Tyr Val Lys His Ser Ile Ser Phe Lys Glu Asn Ser Ser Cys 
         275                280                285
Gly Arg Phe Asp Ile Thr Ile Gly Pro Lys Gln Asn Met Gly Lys Thr 
     290                295                300
Ile Glu Gly Ile Thr Val Thr Val His Met Pro Lys Val Val Leu Asn 
 305                310                315                320
Met Asn Leu Thr Pro Thr Gln Gly Ser Tyr Thr Phe Asp Pro Val Thr 
                 325                330                335
Lys Val Leu Thr Trp Asp Val Gly Lys Ile Thr Pro Gln Lys Leu Pro 
             340                345                350
Ser Leu Lys Gly Leu Val Asn Leu Gln Ser Gly Ala Pro Lys Pro Glu 
         355                360                365
Glu Asn Pro Ser Leu Asn Ile Gln Phe Lys Ile Gln Gln Leu Ala Ile 
     370                375                380
Ser Gly Leu Lys Val Asn Arg Leu Asp Met Tyr Gly Glu Lys Tyr Lys 
 385                390                395                400
Pro Phe Lys Gly Val Lys Tyr Val Thr Lys Ala Gly Lys Phe Gln Val 
                 405                410                415
Arg Thr 
             420



<210> 2814
<211> 3295
<212> DNA
<213> Rattus norvegicus
<308> L07074
<400> 2814

ccacacttc  cccactggc  tcttcttca  catgattca  agtcttttc  tgatcaact  60
tgctgggga  attttcctg  agaagcact  gaaaagcgt  gtcagccgc  ctgtttgcg  120
ttacttttt  gaggcccaa  agagagcta  ggaggctga  aatgtgcct  ccgtcatcc  180
cacacctca  cactacctt  tgagcgttt  ccggcacaa  atcttcttt  tggctgtga  240
ccagacgga  gtcccgcct  tgtttgtca  tgaattcct  caccgagta  tggacacat  300
tcaggacta  ttcggggtc  gctctgagc  agtgatcaa  gacaacgtg  tggtggtct  360
cgaggtgtt  gaagagatg  tggacaatg  gttcccctt  gctacggag  cgaacatcc  420
caaggagct  ataaagcct  ccaccattc  ccggacagt  gtcaacacc  tcacaggaa  480
caccaatgt  ggcgaccag  ttccaactg  gcagctgtc  gtggtgcct  ggcgacgga  540
tggggtgaa  tataccaac  acgaggcct  tttcgacgt  gttgaagag  tagacgcca  600
cattgacaa  tcaggttcc  cagtcaccg  tgagatcca  ggggtgatt  atgcctgtg  660
taaactgac  gggatgcca  atctcacgc  gtccttcat  aaccccagg  tgctggatg  720
tgttagctt  cacccctgt  tccgtttca  gcgctggga  tctgagcgc  tcctctcct  780
catccctcc  gacggcaac  tccgcctgc  ctcctacca  gtcagtgca  agaacctag  840
tgccattcc  gtctatgtc  aacacagca  cagcttccg  gacagtggc  cacttggac  900
ctttgaaat  acagtgggg  cgaagcaga  catggggaa  accatagag  gtgtgactg  960
aaccagcca  atgcccaaa  gagtcttga  catgagcct  actccatcc  aggggacac  1020
cacgtttga  ccggtgaca  agatgctgt  ttgggatgt  ggaaaaata  acccgcaaa  1080
gctgccaag  ttgaagggg  caatgggtc  ccaggtcgg  gcttctaaa  ccgatgaga  1140
ccctacaat  aaccttcag  tcaagatcc  gcagctggc  atttctgga  tcaaagtga  1200
ccgtctgga  atgtacgga  agaagtaca  gccctttaa  ggcataaaa  acatgacca  1260
agccggcaa  ttccaagtc  gaacctgaa  ggaaagtct  ggtgaagga  cactcacga  1320
cactttttc  tttcttact  gtctaaaag  aaaatgtca  cctgtttct  aggtcagtt  1380
cctcaggct  catctgccc  ctttgtcct  tgtcttcag  accacataa  tgatggagg  1440
acaggaggt  cctcaggga  aacgaagcc  aacccatcg  agcactgac  gagtcctag  1500
gtgtgggct  gagagtggt  gcctgtcgc  ctgcatttc  cctcttaac  cggttgccg  1560
tgggaaaag  ccggccttt  acgtttggt  tcaatcacc  aaccccaat  gaagatgtc  1620
atattgatt  ttttttatg  tagaaagat  tgaaagaga  aaaaaaaaa  aatagaaaa  1680
aatgggtgt  agtccaaga  agagcagtt  agatttgat  ggtctgggt  gtaactcgg  1740
gatcaagtg  cgacctggg  cctgtgcaa  ccctggttc  ttcctggta  cgtccacaa  1800
acaagacag  tctgctcta  gaggggcaa  accaagaag  tggtgtgaa  agagttgtg  1860
agagagagg  cacagtgaa  agttggtga  aacagttat  agaatctcc  caggggcta  1920
gacgagcag  acgcagtgt  tctttctga  cccctctta  gtgtagaaa  gatttgcat  1980
tccaggact  tcaaagttc  agtccacgc  tgaactgaa  ctgcagtgg  atcagcgtc  2040
tttggagac  aaggtgcca  acacagcct  cctctggag  ttctcactc  ctgtttgcg  2100
tggcccatc  tcctggtgg  aaggttacc  gtcagagca  cttacagcc  tctgctggt  2160
atctgactc  ttggtgggc  cgcccccca  aaacagcag  gatctcggt  caggcagat  2220
tgtgaatga  agtggcaga  tcgaggtga  ctactccat  gacagccat  ctcggtgac  2280
accattaca  taatgtttg  gaggccgga  tggcctatg  cttgctttt  cctgtctga  2340
ggtcccatc  gaacccctg  gtaggtgtg  acccaccga  gacatgcgc  agtgcacaa  2400
tgcttccca  tgtctgttc  ggtctccag  cagacagct  ccagtccgt  cttacaacc  2460
aaaaaggtg  cttgagcct  tgaatagaa  accatagga  ggcaggcag  gttggccac  2520
agtagctcc  cattactcc  cagtttaaa  ccagcagct  aaggagcag  gtatctcaa  2580
ctgtttcaa  gtgtccttt  gtcatttta  taaacacat  aggtgcggg  gtgtgttgt  2640
tttaactta  agcagcctg  gctctgtat  gtgcctgga  ggagaagac  ggcttgctt  2700
agtctgcag  gctccccct  aagtcccgt  tctaagtgc  tgtgcttgc  tgcagggct  2760
tcccctgaa  tcccgtgtc  aagtgcttg  gcttgctta  tttctattg  ttgctagtg  2820
tctcatgct  tggccagga  ttatttttg  tgcccagta  agttactct  tggtttcct  2880
gtgtggtga  ctgcgctgt  tacagtcag  tgttcctta  caggatctg  actagtgta  2940
ccccacacc  tgctgcagg  gacacttca  gtcactttc  caggctctg  gggattccg  3000
ggtttcttg  gtcataggt  ctatttgca  cggtccccg  gtgtgttta  gtttgtacg  3060
gtggctcat  actcccgag  gcacaggat  gcttgtttt  ccaggcaga  acagggttg  3120
agtacgggc  ccccaggcc  agacaccgt  gatacagcc  agcctcgcc  tccccacct  3180
gtggctgtc  gcagaggtg  cgcaggcct  tccatagct  ctcgctctg  gtgtggtcc  3240
tgtgtggaa  cagcatttc  gttgaagtc  taataaagc  ttaccagtc  tgtgg  3295



<210> 2815
<211> 418
<212> PRT
<213> Rattus norvegicus
<308> P53678
<400> 2815

Met Ile His Ser Leu Phe Leu Ile Asn Ser Ala Gly Asp Ile Phe Leu 
  1               5                  10                  15
Glu Lys His Trp Lys Ser Val Val Ser Arg Ser Val Cys Asp Tyr Phe 
             20                  25                  30
Phe Glu Ala Gln Glu Arg Ala Thr Glu Ala Glu Asn Val Pro Pro Val 
         35                  40                  45
Ile Pro Thr Pro His His Tyr Leu Leu Ser Val Tyr Arg His Lys Ile 
     50                  55                  60
Phe Phe Val Ala Val Ile Gln Thr Glu Val Pro Pro Leu Phe Val Ile 
 65                  70                  75                  80
Glu Phe Leu His Arg Val Val Asp Thr Phe Gln Asp Tyr Phe Gly Val 
                 85                  90                  95
Cys Ser Glu Pro Val Ile Lys Asp Asn Val Val Val Val Tyr Glu Val 
             100                105                110
Leu Glu Glu Met Leu Asp Asn Gly Phe Pro Leu Ala Thr Glu Ser Asn 
         115                120                125
Ile Leu Lys Glu Leu Ile Lys Pro Pro Thr Ile Leu Arg Thr Val Val 
     130                135                140
Asn Thr Ile Thr Gly Ser Thr Asn Val Gly Asp Gln Leu Pro Thr Gly 
 145                150                155                160
Gln Leu Ser Val Val Pro Trp Arg Arg Thr Gly Val Lys Tyr Thr Asn 
                 165                170                175
Asn Glu Ala Tyr Phe Asp Val Val Glu Glu Ile Asp Ala Ile Ile Asp 
             180                185                190
Lys Ser Gly Ser Thr Val Thr Ala Glu Ile Gln Gly Val Ile Asp Ala 
         195                200                205
Cys Val Lys Leu Thr Gly Met Pro Asp Leu Thr Leu Ser Phe Met Asn 
     210                215                220
Pro Arg Leu Leu Asp Asp Val Ser Phe His Pro Cys Val Arg Phe Lys 
 225                230                235                240
Arg Trp Glu Ser Glu Arg Ile Leu Ser Phe Ile Pro Pro Asp Gly Asn 
                 245                250                255
Phe Arg Leu Leu Ser Tyr His Val Ser Ala Gln Asn Leu Val Ala Ile 
             260                265                270
Pro Val Tyr Val Lys His Ser Ile Ser Phe Arg Asp Ser Gly Ser Leu 
         275                280                285
Gly Arg Phe Glu Ile Thr Val Gly Pro Lys Gln Thr Met Gly Lys Thr 
     290                295                300
Ile Glu Gly Val Thr Val Thr Ser Gln Met Pro Lys Gly Val Leu Asn 
 305                310                315                320
Met Ser Leu Thr Pro Ser Gln Gly Thr His Thr Phe Asp Pro Val Thr 
                 325                330                335
Lys Met Leu Ser Trp Asp Val Gly Lys Ile Asn Pro Gln Lys Leu Pro 
             340                345                350
Ser Leu Lys Gly Thr Met Gly Leu Gln Val Gly Ala Ser Lys Pro Asp 
         355                360                365
Glu Asn Pro Thr Ile Asn Leu Gln Phe Lys Ile Gln Gln Leu Ala Ile 
     370                375                380
Ser Gly Leu Lys Val Asn Arg Leu Asp Met Tyr Gly Glu Lys Tyr Lys 
 385                390                395                400
Pro Phe Lys Gly Ile Lys Tyr Met Thr Lys Ala Gly Lys Phe Gln Val 
                 405                410                415
Arg Thr 
             420



<210> 2816
<211> 3461
<212> DNA
<213> Homo sapiens
<308> D38293
<400> 2816

gctgagagc  gcaaggcca  agttgaaaa  ttacagagt  ctgaggctt  agactgaaa  60
aggcttctt  tgtcactga  aatcgccac  atgatccat  gtcttttct  gatcaactc  120
tctggagac  ttttcctgg  gaaacattg  aaaagtgtg  tcagccgtt  tgtttgtga  180
tactttttt  aggcgcaag  gagagctac  gaggcagaa  atgtgcctc  ggttatccc  240
acccctcac  actatctct  aagtgttta  cgccacaag  tcttttttg  ggccgtgat  300
cagacggag  tcccccctc  gtttgtcat  gagtttctt  accgagtgg  ggacacatt  360
caggattat  ttggagtct  ttcagagcc  gtgatcaaa  acaatgtag  tgtggttta  420
gaggtattg  aagagatgc  tgacaatgg  tttccattg  ctaccgagt  gaacattct  480
aaagaactc  taaagcctc  taccatcct  cgaacggtt  tcaacacca  cacaggaag  540
acgaatgtg  gtgaccagc  tcccactgg  cagctgtca  tggtgcctt  gcgacggac  600
ggggtgaaa  ataccaaca  tgaggccta  tttgatgtg  ttgaagaga  tgatgcaat  660
attgataaa  caggctcca  aattactgc  gagatccag  gggtgattg  tgcctgtgt  720
aagctgact  gcatgccag  ccttacact  tccttcatg  accctaggt  gttggatga  780
gtcagcttc  atccttgtg  tcgtttcaa  cgctgggaa  ctgagcgca  cctctcctt  840
atccctcct  atggaaact  ccgcctgct  tcttaccat  tcagtgcac  gaatctggt  900
gcaatccca  tgtatgtca  acataacat  agtttccgg  acagtagtt  ccttggacg  960
tttgaaata  cggtgggac  caagcagac  atggggaag  ccattgagg  agtgactgt  1020
accagccag  tgcccaagg  ggtcctgaa  atgagcctt  ctccatcac  ggggacaca  1080
acattcgac  cagtcacaa  gatgctgtc  tgggatgta  gaaaaataa  tccacaaaa  1140
ctaccaagt  tgaagggga  catgagtct  caggctgga  cttccaaac  agatgaaaa  1200
cccacaatt  acctgcagt  taagatcca  cagctggcc  tttctggac  caaggtgaa  1260
cgtctggat  tgtatggag  aaagtacaa  ccctttaag  gcataaaat  catgaccaa  1320
gctgggaag  tccaagttc  aacctgaag  gagcatttg  tgagggaat  gtcttgcac  1380
ttttttcat  tcttacttg  ctaaaagta  aaaaaaata  cagcctgtc  cctaggtca  1440
tcccctcct  gacccaccc  ctccctttt  tccttagcc  tcagtgcca  ggaactaat  1500
aagggagga  aaggtcacc  gggagaact  gacagaact  aaacacagc  acaccagtt  1560
tcaaggaca  ggtgtgtga  gggggtagg  agcttggtg  ttatgtaac  attttaaac  1620
tggtttcta  aggaaagac  aacatttgt  tagcttgct  ggctttaat  atctaaagc  1680
aatgaaaga  ttctttgtt  attttttaa  atagaaaga  taaaaagaa  gaaagatgg  1740
aagaaaatg  atgtcagtc  aggaaaggc  acttaagga  ctgctctat  aaggagaag  1800
aagaggaaa  agaagtaaa  gagttagga  gagacactt  aatgaaaga  tggcaagaa  1860
agcagtcgg  ctctacctt  aggagggat  ggaaggaaa  agtgtgttg  tttctttct  1920
attcctcta  tcatgtaga  aacacttgt  cttctggaa  tggactgga  actttttaa  1980
tttgagtcc  ctattgaca  ggaaacccc  gtggaatca  attttccct  aaagaccat  2040
atggtatcg  actagtttt  agacactgc  tgttgctgt  catcagcac  tggtctctt  2100
tcttcagtg  gaaggtgac  cgccttctt  ccatggtgg  tgcctaaag  gcttctttt  2160
taacccaaa  cagttctac  cacttcctt  tacagaatt  accggccat  ttcctgtta  2220
ctgatcctt  tacaggatt  ttaaaaagt  agagagttt  agagaagcc  atcccataa  2280
ccccagtgc  gccagggcc  gtgtgtcat  gtactggag  agagggccg  ctcttccca  2340
gaaggtgag  acagctgtg  gtgagtgag  tcatatctc  atttgtcag  gctggactg  2400
taccagatc  taaccttcc  gttggtcgg  aacttttcc  tctgtcacc  tagaaaaag  2460
gaaagctta  catcgaggg  gtggttgat  cttgaagct  cttggtaaa  ttatcattt  2520
tcagtcttt  cttttgtac  cctatcatg  attcattaa  atctaccag  cccttttca  2580
tctaagaca  aacatttct  ctaaatctc  gaataaaat  agtgctgta  gaagatgga  2640
tgtgttgat  atgggtgta  gcaacccag  ttaagaaac  tggcaacta  agggatacc  2700
caggctttc  ttcccagtg  gtcattttt  tcctagttc  gtgtgtctg  tactattta  2760
atatttata  aaaagggtt  ttgtttata  cttaaggaa  gatactgtg  tctgcttgg  2820
gcatggaga  aaaggaaga  ccgtactct  cacacccta  agctttctc  aaatattgt  2880
caaagtttt  gctagtttt  tcttctgac  ttggactag  ttttgcctg  agttgtgtt  2940
ctttgtgat  ttcctctgg  atagtgtac  gtacacaac  agatgtgtt  cacactccg  3000
gactccgca  tttgtcctg  agtgacata  acatccacc  tggaaaggg  agcatctct  3060
ccgagattc  aagtacttg  agcacctct  ctgaggaac  tacaggatt  taaggtttc  3120
taggtcact  aacaactaa  cttggtccc  gaatatttc  aggtttgta  gtgcagcag  3180
tttatttcc  ctagaactc  tcctgtttc  agggaagta  ctaagaaga  atagagtgt  3240
tctagggta  gggacctgc  ggtgtaagc  tagatgaaa  aactgtcct  tcacatgtg  3300
agcaggcca  ggagtgtag  gggcatcgc  gccgccatt  ctgcagcat  accataagc  3360
gtgcagggt  tctccatcg  gctgtttgg  tccatgtgt  tttaacatg  gcagaagta  3420
cttctctgt  taagtttaa  aaagttgag  ttcaaccag  c  3461



<210> 2817
<211> 418
<212> PRT
<213> Homo sapiens
<308> P53677
<400> 2817

Met Ile His Ser Leu Phe Leu Ile Asn Ser Ser Gly Asp Ile Phe Leu 
  1               5                  10                  15
Glu Lys His Trp Lys Ser Val Val Ser Arg Ser Val Cys Asp Tyr Phe 
             20                  25                  30
Phe Glu Ala Gln Glu Arg Ala Thr Glu Ala Glu Asn Val Pro Pro Val 
         35                  40                  45
Ile Pro Thr Pro His His Tyr Leu Leu Ser Val Tyr Arg His Lys Ile 
     50                  55                  60
Phe Phe Val Ala Val Ile Gln Thr Glu Val Pro Pro Leu Phe Val Ile 
 65                  70                  75                  80
Glu Phe Leu His Arg Val Val Asp Thr Phe Gln Asp Tyr Phe Gly Val 
                 85                  90                  95
Cys Ser Glu Pro Val Ile Lys Asp Asn Val Val Val Val Tyr Glu Val 
             100                105                110
Leu Glu Glu Met Leu Asp Asn Gly Phe Pro Leu Ala Thr Glu Ser Asn 
         115                120                125
Ile Leu Lys Glu Leu Ile Lys Pro Pro Thr Ile Leu Arg Thr Val Val 
     130                135                140
Asn Thr Ile Thr Gly Ser Thr Asn Val Gly Asp Gln Leu Pro Thr Gly 
 145                150                155                160
Gln Leu Ser Val Val Pro Trp Arg Arg Thr Gly Val Lys Tyr Thr Asn 
                 165                170                175
Asn Glu Ala Tyr Phe Asp Val Ile Glu Glu Ile Asp Ala Ile Ile Asp 
             180                185                190
Lys Ser Gly Ser Thr Ile Thr Ala Glu Ile Gln Gly Val Ile Asp Ala 
         195                200                205
Cys Val Lys Leu Thr Gly Met Pro Asp Leu Thr Leu Ser Phe Met Asn 
     210                215                220
Pro Arg Leu Leu Asp Asp Val Ser Phe His Pro Cys Val Arg Phe Lys 
 225                230                235                240
Arg Trp Glu Ser Glu Arg Ile Leu Ser Phe Ile Pro Pro Asp Gly Asn 
                 245                250                255
Phe Arg Leu Leu Ser Tyr His Val Ser Ala Gln Asn Leu Val Ala Ile 
             260                265                270
Pro Val Tyr Val Lys His Asn Ile Ser Phe Arg Asp Ser Ser Ser Leu 
         275                280                285
Gly Arg Phe Glu Ile Thr Val Gly Pro Lys Gln Thr Met Gly Lys Thr 
     290                295                300
Ile Glu Gly Val Thr Val Thr Ser Gln Met Pro Lys Gly Val Leu Asn 
 305                310                315                320
Met Ser Leu Thr Pro Ser Gln Gly Thr His Thr Phe Asp Pro Val Thr 
                 325                330                335
Lys Met Leu Ser Trp Asp Val Gly Lys Ile Asn Pro Gln Lys Leu Pro 
             340                345                350
Ser Leu Lys Gly Thr Met Ser Leu Gln Ala Gly Ala Ser Lys Pro Asp 
         355                360                365
Glu Asn Pro Thr Ile Asn Leu Gln Phe Lys Ile Gln Gln Leu Ala Ile 
     370                375                380
Ser Gly Leu Lys Val Asn Arg Leu Asp Met Tyr Gly Glu Lys Tyr Lys 
 385                390                395                400
Pro Phe Lys Gly Ile Lys Tyr Met Thr Lys Ala Gly Lys Phe Gln Val 
                 405                410                415
Arg Thr 
             420



<210> 2818
<211> 4377
<212> DNA
<213> Rattus norvegicus
<308> L07736
<400> 2818

agtcggtcg  ctccgagct  agtgaggac  taaagcaga  gactgtggt  cggaggaca  60
tgcttgctc  ggggagtgc  gagcaatag  tccccactc  agatggcag  ggctcacca  120
gctgtggcc  tccagttca  cgtcacccc  gatggcatt  acctccgcc  gagccacga  180
gccctcaaa  agatctgcc  gtcggggct  cactcctgg  agaagaagt  catccggtt  240
aagaatggc  tcatcactg  tgtgttccc  gcgaatccg  ccagctggc  tatcgtggt  300
gtgggtgtg  tttcatcca  gcatgccaa  gtggacccc  ccctgggca  gatcgcaaa  360
atcagtcgg  ccctagaca  cactggccg  atgtcaagc  agacgaaga  cattgtgag  420
ggcgtcctc  ttggtacag  gctctgggt  gcagtcatc  tgaccatgc  ctactcgct  480
aaggtgctg  tctcctacc  cggctggat  tttgcagaa  acggcaaaa  gagccgcag  540
accaagatc  ggatggcta  ggtcaaggt  ctctcaggt  ggaagccca  gttgtacag  600
ttccagacg  ctctgccac  cctgcctgt  ccagctgtc  aagatactg  gagcaggta  660
ctggaatct  taaggccac  gatgaagga  gaagacttc  agcgcatga  agcactggc  720
caggatttt  ctgtcaacc  cggacccaa  ttgcagtgg  atttgaagc  aaaatcctg  780
tgggccaca  attacgtga  tgactggtg  gaagaatat  tctacctgc  gggccgagg  840
ccgctcatg  tcaacagca  ctactacgc  atggagatg  tgtacatca  cccaaccca  900
atccaggca  cgagagctg  caacaccat  cacgccata  tgctgtatc  tcgcacatt  960
gaccgtgag  aactcaaac  cattcgtct  ctgggatcc  ccattccac  ctgctcagc  1020
cagtgggag  gactcttca  tacttcccg  atccctggg  aggagacag  caccatcca  1080
catatcaag  acagcaggc  cattgttgt  taccacaga  ggcggtact  caaggtctg  1140
ctctaccac  atgggaggc  gctgaggcc  cgagagctg  agcagcaga  gcagcagat  1200
ctggatgat  cctcagagc  acagcctgg  gaggccaag  tggccgccc  cactgctgc  1260
gacagagtg  cctgggcaa  gtgtcggca  acctatttt  cacgaggga  aaataagca  1320
tccctggat  cggtggaaa  ggcagcgtt  ttcgtgacg  tggacgaat  ggagcaggg  1380
tacagagag  aggatcctg  ggcatccat  gacagctac  ccaaatccc  gctgcatgg  1440
agatgcttt  acaggtggt  tgacaagtc  atcaccttt  ttgtcttca  aaacagcaa  1500
ataggcata  atgcagagc  ctcctgggc  gacgcgccc  tcgtgggcc  tttgtggga  1560
tatgtcatg  ccaccgacg  cttccagct  ggttactca  aggatggac  ctgtaaagg  1620
gacaccaac  ccaacatcc  taagcccac  aggctacaa  gggacattc  aggagagtg  1680
caggaggtc  tagatgcat  cctgagcag  gccagtctt  tggcaaatg  tgtggacct  1740
cattccttc  catttgact  tttcggcaa  ggcttgatc  agaagtgcc  gacgagtcc  1800
gatgccttc  tccagctgg  gctgcagct  gcacattac  aggacatgg  caagttctg  1860
ctcacatat  aggcctcca  gacccggct  ttccgagaa  ggaggacag  gactgtacg  1920
tcctgcact  tggagtcct  caactttgt  caggccatg  tggacccca  gtcaacggc  1980
gagcagagg  tcaagctgt  caagatagc  tgtgagaag  accagcacc  gtaccgcct  2040
gccatgacg  gcgccggca  cgaccgcca  ctcttctgc  tctatgtgg  gtccaagta  2100
cttgcagtc  actcacctt  cctgaagga  gtattgtct  agccatgga  gttgtctac  2160
agccagact  ctcagcagc  ggtggagct  tttgacttt  agaaaaacc  tgactatgt  2220
tcctgtgga  ggggctttg  gccggttgc  gatgacggc  atggtgtct  ctacattat  2280
gtgggagag  atttcatcc  cttccatat  tcttccaag  tctctagcc  tgagacaga  2340
tcacaccgc  ttgggaagc  cttgagaca  gccatgatg  acattatca  cttgtttgg  2400
ctcaccatc  attctaaaa  gtaaacccc  gagccacac  gaaggaaaa  ggaccctcg  2460
gatacaaac  aaatgaata  atgttgctc  tgaccatag  acaggcaga  aattgctct  2520
ataaaactc  gttttcctt  cagaaggtt  accgtcagt  tccctagaa  aacagtagg  2580
ttcacgtgt  aattgtgac  ctactacat  cagagatgc  ttggctcca  gaatattgg  2640
cacagtccc  tgatgtctt  tgaatcggc  cctactgga  aaagggatt  aaatgctgg  2700
gaattcctg  attctgggg  ttgtttctt  acatgtgtt  gaggtgaca  acttcctca  2760
tggtgaccc  gtgaatact  gggcgtctg  ctccaccca  gcagtgtga  catcacctt  2820
tggaaagag  aagtgtctt  agagccagc  gaggcaaca  ctgtagcta  cacatctgt  2880
acacactaa  ggaatggtt  ggcctgggg  ttaaggttc  gctatgagt  acagccact  2940
tccctttgg  agttcacat  tccaggaag  agagtacca  ctccccagt  ccaccttcc  3000
cacacatct  caaaaccca  tgccttaaa  aaggggccc  ttggcaagc  ggaccatag  3060
gaagactta  catctgtga  gcctttggg  ggatatgtg  ggatgctgc  tccccttac  3120
ggttcctgc  taaagatgt  cctaagtaa  cacttcccc  acccctaga  aatgaggtc  3180
ttggtgaag  cagggatgc  ggagtctca  tgcctgcca  ttccattaa  ccacaaaat  3240
gcagacatg  gtccacaga  ggaggggct  ggtagtcaa  ggctgcata  ctggacaac  3300
gcgggagag  gtggcttgc  gtatttgac  gctgttggc  agaggagtg  gaccctggt  3360
accaagtca  acatactga  acaggcagc  aaagctcac  gagccagga  atatagata  3420
atactggct  gtattctgg  agatacacc  ctgggctta  cttctaatc  cacccagtc  3480
gattccaac  agagtcaaa  tccatagaa  gctaggtca  tttggcgac  gactcaggg  3540
tctcaagta  tgggtgctt  tacccacat  ccatccctc  gtgggagtg  ctttcttga  3600
agcatccaa  gggctaaag  agctctacc  agtctgttt  gtatttaat  taaacatta  3660
cattaatgg  gtggtctct  ctacctgtc  ccatcctgt  ctgacaagc  tagctctcc  3720
aggtttaca  catgtattt  ttttccagt  cccctttgg  cttgtttga  tcctgcccc  3780
gtgccagaa  tggcccaga  gtgaggggt  gggtgacca  cagtgcaga  aggtgctgg  3840
tgaacagtt  atgtgtgtc  tatgggtat  catgtataa  ttttgtaat  taaaaaaaa  3900
aatcatacc  aaaagggcc  aagtttttt  tttttttac  aaaaccaag  aaacaaaag  3960
caacataaa  acataagca  aaacaaact  ttgtaagtc  gagcggcct  actctcgct  4020
ctgtgacca  tcaccaacc  gtgttactc  gagtagccc  gctagtgcc  gagtgggac  4080
ttcctctct  aggtttcca  tgtccttgc  gctcctgag  agttaccaa  gcaatttcg  4140
attccttac  aggcagaag  gtgggctct  actgtatgt  ttcaaagga  gaggtaaga  4200
tattgtgta  ttaatttaa  gtggaacaa  atatagtct  accgcagcc  aggttcaaa  4260
ttggtgttc  aatctgtcc  ttgcatgta  ataccatat  tgtttggat  taaatctta  4320
aagtgcatg  gtgagcgaa  gtagctggc  attaataaa  cattaatac  gtctact  4377



<210> 2819
<211> 773
<212> PRT
<213> Rattus norvegicus
<308> P32198
<400> 2819

Met Ala Glu Ala His Gln Ala Val Ala Phe Gln Phe Thr Val Thr Pro 
  1               5                  10                  15
Asp Gly Ile Asp Leu Arg Leu Ser His Glu Ala Leu Lys Gln Ile Cys 
             20                  25                  30
Leu Ser Gly Leu His Ser Trp Lys Lys Lys Phe Ile Arg Phe Lys Asn 
         35                  40                  45
Gly Ile Ile Thr Gly Val Phe Pro Ala Asn Pro Ser Ser Trp Leu Ile 
     50                  55                  60
Val Val Val Gly Val Ile Ser Ser Met His Ala Lys Val Asp Pro Ser 
 65                  70                  75                  80
Leu Gly Met Ile Ala Lys Ile Ser Arg Thr Leu Asp Thr Thr Gly Arg 
                 85                  90                  95
Met Ser Ser Gln Thr Lys Asn Ile Val Ser Gly Val Leu Phe Gly Thr 
             100                105                110
Gly Leu Trp Val Ala Val Ile Met Thr Met Arg Tyr Ser Leu Lys Val 
         115                120                125
Leu Leu Ser Tyr His Gly Trp Met Phe Ala Glu His Gly Lys Met Ser 
     130                135                140
Arg Ser Thr Lys Ile Trp Met Ala Met Val Lys Val Leu Ser Gly Arg 
 145                150                155                160
Lys Pro Met Leu Tyr Ser Phe Gln Thr Ser Leu Pro Arg Leu Pro Val 
                 165                170                175
Pro Ala Val Lys Asp Thr Val Ser Arg Tyr Leu Glu Ser Val Arg Pro 
             180                185                190
Leu Met Lys Glu Glu Asp Phe Gln Arg Met Thr Ala Leu Ala Gln Asp 
         195                200                205
Phe Ala Val Asn Leu Gly Pro Lys Leu Gln Trp Tyr Leu Lys Leu Lys 
     210                215                220
Ser Trp Trp Ala Thr Asn Tyr Val Ser Asp Trp Trp Glu Glu Tyr Ile 
 225                230                235                240
Tyr Leu Arg Gly Arg Gly Pro Leu Met Val Asn Ser Asn Tyr Tyr Ala 
                 245                250                255
Met Glu Met Leu Tyr Ile Thr Pro Thr His Ile Gln Ala Ala Arg Ala 
             260                265                270
Gly Asn Thr Ile His Ala Ile Leu Leu Tyr Arg Arg Thr Leu Asp Arg 
         275                280                285
Glu Glu Leu Lys Pro Ile Arg Leu Leu Gly Ser Thr Ile Pro Leu Cys 
     290                295                300
Ser Ala Gln Trp Glu Arg Leu Phe Asn Thr Ser Arg Ile Pro Gly Glu 
 305                310                315                320
Glu Thr Asp Thr Ile Gln His Ile Lys Asp Ser Arg His Ile Val Val 
                 325                330                335
Tyr His Arg Gly Arg Tyr Phe Lys Val Trp Leu Tyr His Asp Gly Arg 
             340                345                350
Leu Leu Arg Pro Arg Glu Leu Glu Gln Gln Met Gln Gln Ile Leu Asp 
         355                360                365
Asp Pro Ser Glu Pro Gln Pro Gly Glu Ala Lys Leu Ala Ala Leu Thr 
     370                375                380
Ala Ala Asp Arg Val Pro Trp Ala Lys Cys Arg Gln Thr Tyr Phe Ala 
 385                390                395                400
Arg Gly Lys Asn Lys Gln Ser Leu Asp Ala Val Glu Lys Ala Ala Phe 
                 405                410                415
Phe Val Thr Leu Asp Glu Ser Glu Gln Gly Tyr Arg Glu Glu Asp Pro 
             420                425                430
Glu Ala Ser Ile Asp Ser Tyr Ala Lys Ser Leu Leu His Gly Arg Cys 
         435                440                445
Phe Asp Arg Trp Phe Asp Lys Ser Ile Thr Phe Val Val Phe Lys Asn 
     450                455                460
Ser Lys Ile Gly Ile Asn Ala Glu His Ser Trp Ala Asp Ala Pro Ile 
 465                470                475                480
Val Gly His Leu Trp Glu Tyr Val Met Ala Thr Asp Val Phe Gln Leu 
                 485                490                495
Gly Tyr Ser Glu Asp Gly His Cys Lys Gly Asp Thr Asn Pro Asn Ile 
             500                505                510
Pro Lys Pro Thr Arg Leu Gln Trp Asp Ile Pro Gly Glu Cys Gln Glu 
         515                520                525
Val Ile Asp Ala Ser Leu Ser Ser Ala Ser Leu Leu Ala Asn Asp Val 
     530                535                540
Asp Leu His Ser Phe Pro Phe Asp Ser Phe Gly Lys Gly Leu Ile Lys 
 545                550                555                560
Lys Cys Arg Thr Ser Pro Asp Ala Phe Ile Gln Leu Ala Leu Gln Leu 
                 565                570                575
Ala His Tyr Lys Asp Met Gly Lys Phe Cys Leu Thr Tyr Glu Ala Ser 
             580                585                590
Met Thr Arg Leu Phe Arg Glu Gly Arg Thr Glu Thr Val Arg Ser Cys 
         595                600                605
Thr Met Glu Ser Cys Asn Phe Val Gln Ala Met Met Asp Pro Lys Ser 
     610                615                620
Thr Ala Glu Gln Arg Leu Lys Leu Phe Lys Ile Ala Cys Glu Lys His 
 625                630                635                640
Gln His Leu Tyr Arg Leu Ala Met Thr Gly Ala Gly Ile Asp Arg His 
                 645                650                655
Leu Phe Cys Leu Tyr Val Val Ser Lys Tyr Leu Ala Val Asp Ser Pro 
             660                665                670
Phe Leu Lys Glu Val Leu Ser Glu Pro Trp Arg Leu Ser Thr Ser Gln 
         675                680                685
Thr Pro Gln Gln Gln Val Glu Leu Phe Asp Phe Glu Lys Asn Pro Asp 
     690                695                700
Tyr Val Ser Cys Gly Gly Gly Phe Gly Pro Val Ala Asp Asp Gly Tyr 
 705                710                715                720
Gly Val Ser Tyr Ile Ile Val Gly Glu Asn Phe Ile His Phe His Ile 
                 725                730                735
Ser Ser Lys Phe Ser Ser Pro Glu Thr Asp Ser His Arg Phe Gly Lys 
             740                745                750
His Leu Arg Gln Ala Met Met Asp Ile Ile Thr Leu Phe Gly Leu Thr 
         755                760                765
Ile Asn Ser Lys Lys 
     770



<210> 2820
<211> 2546
<212> DNA
<213> Homo sapiens
<308> BC000185
<400> 2820

gctgccgct  ccgcacctc  gtagctgac  cggtactct  tgaagatgg  agaagctca  60
caagctgtg  cctttcagt  cacggtcac  ccggacggg  ttgacctgc  gctgagcca  120
gaagctctt  gacaaatct  tctctctgg  cttcattcc  ggaaaaaga  gttcatcag  180
ttcaagaac  gcatcatca  tggcgtgta  ccggcaagc  cctccagtt  gcttatcgt  240
gtggtgggc  tgatgacaa  gatgtacgc  aagatcgac  cctcgttag  aataattgc  300
aaaatcaat  ggactctgg  aacggccaa  tgcatgtcc  gccagacga  gaacgtggt  360
agcggcgtg  tgtttggca  cggcctgtg  gtggccctc  tcgtcacca  gcgctactc  420
ctgaaagtg  tgctctcct  ccacgggtg  atgttcact  agcacggca  gatgagtcg  480
gccaccaag  tctggatgg  tatggtcaa  atcttttca  gccgaaaac  catgttgta  540
agcttccag  catcgctgc  tcgcctgcc  gtcccggct  tcaaagaca  tgtgaacag  600
tatctacag  cggtgaggc  tcttatgaa  gaagaagac  tcaaacgga  gacagcact  660
gctcaagat  ttgctgtcg  tcttggacc  agattacag  ggtatttga  gttaaaatc  720
tggtgggct  caaattacg  gagcgactg  tgggaggag  acatctacc  ccgaggacg  780
gggccgctc  tggtgaaca  caactatta  gccatggat  tgctgtata  ccttccaac  840
cacattcag  cagcaagag  cggcaacgc  atccatgcc  tcctgcttt  caggcgcaa  900
ctggaccgg  aggaaatca  accaattcg  cttttggga  ccacgattc  actctgctc  960
gctcagtgg  agcggatgt  taatacttc  cggatccca  gagaggaga  agacaccat  1020
cagcacatg  gagacagca  gcacatcgt  gtgtaccat  gaggacgct  cttcaaggt  1080
tggctctac  atgatgggc  gctgctgaa  ccccgggag  tggagcagc  gatgcagag  1140
atcctggac  atacctcgg  gcctcagcc  ggggaggcc  ggctggcag  cctcaccgc  1200
ggagacaga  ttccctggg  caggtgtcg  caggcctat  ttggacgtg  gaaaaataa  1260
cagtctctt  atgctgtgg  gaaagcagc  ttcttcgtg  cgttagatg  aactgaaga  1320
ggatacaga  gtgaagacc  ggatacgtc  atggacagc  acgccaaat  tctactaca  1380
ggccgatgt  acgacaggt  gtttgacaa  tcgttcacg  ttgttgtct  caaaaacgg  1440
aagatgggc  tcaacgctg  acactcctg  gcagatgcg  cgatcgtgg  ccacctttg  1500
gagtacgtc  tgtccattg  cagcctcca  ctgggctat  cggaggatg  gcactgcaa  1560
ggcgacatc  atccgaaca  tccgtaccc  accaggctg  agtgggaca  cccggggga  1620
tgtcaagag  ttatagaga  ctccctgaa  accgcaaat  ttctggcaa  cgacgtgga  1680
ttccattcc  tcccattcg  agcctttgg  aaaggaatc  tcaagaaat  tcgcacgag  1740
ccagacgcc  ttgtgcagc  ggccctcca  ctggcgcac  acaaggaca  gggcaagtt  1800
tgcctcaca  acgaggcct  catgacccg  ctcttccga  aggggagga  ggagaccgt  1860
cgctcctgc  ccactgagt  atgcgactt  gtgcgggcc  tggtggacc  ggcccagac  1920
gtggaacag  ggctgaagt  gttcaagtt  gcgtctgag  agcatcagc  tatgtatcg  1980
ctcgccatg  ccggctctg  gatcgatcg  cacctcttc  gcctttacg  ggtgtctaa  2040
tatctcgct  tggagtccc  tttccttaa  gaagtttta  ctgagcctt  gagattatc  2100
acaagccag  cccctcagc  gcaagtgga  ctgtttgac  tggagaata  cccagagta  2160
gtgtccagc  gagggggct  tggaccggt  gctgatgac  gctatggtg  gtcgtacat  2220
cttgtggga  agaacctca  caatttcca  atttcttcc  agttctctt  ccctgagac  2280
gggattata  gtcaaggac  aagttcaga  acttgagac  aagtggaaa  tctcagcat  2340
tggaaacaa  gccttggag  agaccatgg  catcaccaa  ttcatgtgc  gggctggaa  2400
gaaaagcct  ttgattttc  cttgctgtg  atttattca  ccattccat  gcctcaatg  2460
tgagaacag  gcctgacac  taaaagatg  tcaataaat  tgttaaaag  aaaaaaaaa  2520
aaaaaaaaa  aaaaaaaaa  aaaaaa  2546



<210> 2821
<211> 773
<212> PRT
<213> Homo sapiens
<308> P50416
<400> 2821

Met Ala Glu Ala His Gln Ala Val Ala Phe Gln Phe Thr Val Thr Pro 
  1               5                  10                  15
Asp Gly Ile Asp Leu Arg Leu Ser His Glu Ala Leu Arg Gln Ile Tyr 
             20                  25                  30
Leu Ser Gly Leu His Ser Trp Lys Lys Lys Phe Ile Arg Phe Lys Asn 
         35                  40                  45
Gly Ile Ile Thr Gly Val Tyr Pro Ala Ser Pro Ser Ser Trp Leu Ile 
     50                  55                  60
Val Val Val Gly Val Met Thr Thr Met Tyr Ala Lys Ile Asp Pro Ser 
 65                  70                  75                  80
Leu Gly Ile Ile Ala Lys Ile Asn Arg Thr Leu Glu Thr Ala Asn Cys 
                 85                  90                  95
Met Ser Ser Gln Thr Lys Asn Val Val Ser Gly Val Leu Phe Gly Thr 
             100                105                110
Gly Leu Trp Val Ala Leu Ile Val Thr Met Arg Tyr Ser Leu Lys Val 
         115                120                125
Leu Leu Ser Tyr His Gly Trp Met Phe Thr Glu His Gly Lys Met Ser 
     130                135                140
Arg Ala Thr Lys Ile Trp Met Gly Met Val Lys Ile Phe Ser Gly Arg 
 145                150                155                160
Lys Pro Met Leu Tyr Ser Phe Gln Thr Ser Leu Pro Arg Leu Pro Val 
                 165                170                175
Pro Ala Val Lys Asp Thr Val Asn Arg Tyr Leu Gln Ser Val Arg Pro 
             180                185                190
Leu Met Lys Glu Glu Asp Phe Lys Arg Met Thr Ala Leu Ala Gln Asp 
         195                200                205
Phe Ala Val Gly Leu Gly Pro Arg Leu Gln Trp Tyr Leu Lys Leu Lys 
     210                215                220
Ser Trp Trp Ala Thr Asn Tyr Val Ser Asp Trp Trp Glu Glu Tyr Ile 
 225                230                235                240
Tyr Leu Arg Gly Arg Gly Pro Leu Met Val Asn Ser Asn Tyr Tyr Ala 
                 245                250                255
Met Asp Leu Leu Tyr Ile Leu Pro Thr His Ile Gln Ala Ala Arg Ala 
             260                265                270
Gly Asn Ala Ile His Ala Ile Leu Leu Tyr Arg Arg Lys Leu Asp Arg 
         275                280                285
Glu Glu Ile Lys Pro Ile Arg Leu Leu Gly Ser Thr Ile Pro Leu Cys 
     290                295                300
Ser Ala Gln Trp Glu Arg Met Phe Asn Thr Ser Arg Ile Pro Gly Glu 
 305                310                315                320
Glu Thr Asp Thr Ile Gln His Met Arg Asp Ser Lys His Ile Val Val 
                 325                330                335
Tyr His Arg Gly Arg Tyr Phe Lys Val Trp Leu Tyr His Asp Gly Arg 
             340                345                350
Leu Leu Lys Pro Arg Glu Met Glu Gln Gln Met Gln Arg Ile Leu Asp 
         355                360                365
Asn Thr Ser Glu Pro Gln Pro Gly Glu Ala Arg Leu Ala Ala Leu Thr 
     370                375                380
Ala Gly Asp Arg Val Pro Trp Ala Arg Cys Arg Gln Ala Tyr Phe Gly 
 385                390                395                400
Arg Gly Lys Asn Lys Gln Ser Leu Asp Ala Val Glu Lys Ala Ala Phe 
                 405                410                415
Phe Val Thr Leu Asp Glu Thr Glu Glu Gly Tyr Arg Ser Glu Asp Pro 
             420                425                430
Asp Thr Ser Met Asp Ser Tyr Ala Lys Ser Leu Leu His Gly Arg Cys 
         435                440                445
Tyr Asp Arg Trp Phe Asp Lys Ser Phe Thr Phe Val Val Phe Lys Asn 
     450                455                460
Gly Lys Met Gly Leu Asn Ala Glu His Ser Trp Ala Asp Ala Gln Ile 
 465                470                475                480
Val Ala His Leu Trp Glu Tyr Val Met Ser Ile Asp Ser Leu Gln Leu 
                 485                490                495
Gly Tyr Ala Glu Asp Gly His Cys Lys Gly Asp Ile Asn Pro Asn Ile 
             500                505                510
Pro Tyr Pro Thr Arg Leu Gln Trp Asp Ile Pro Gly Glu Cys Gln Glu 
         515                520                525
Val Ile Glu Thr Ser Leu Asn Thr Ala Asn Leu Leu Ala Asn Asp Val 
     530                535                540
Asp Phe His Ser Phe Pro Phe Val Ala Phe Gly Lys Gly Ile Ile Lys 
 545                550                555                560
Lys Cys Arg Thr Ser Pro Asp Thr Phe Val Gln Leu Ala Leu Gln Leu 
                 565                570                575
Ala His Tyr Lys Asp Met Gly Lys Phe Cys Leu Thr Tyr Glu Ala Ser 
             580                585                590
Met Thr Arg Leu Phe Arg Glu Gly Arg Thr Glu Thr Val Arg Ser Cys 
         595                600                605
Thr Thr Glu Ser Cys Asp Phe Val Arg Ala Met Val Asp Pro Ala Gln 
     610                615                620
Thr Val Glu Gln Arg Leu Lys Leu Phe Lys Leu Ala Ser Glu Lys His 
 625                630                635                640
Gln His Met Tyr Arg Leu Ala Met Thr Gly Ser Gly Ile Asp Arg His 
                 645                650                655
Leu Phe Cys Leu Tyr Val Val Ser Lys Tyr Leu Ala Val Glu Ser Pro 
             660                665                670
Phe Leu Lys Glu Val Leu Ser Glu Pro Trp Arg Leu Ser Thr Ser Gln 
         675                680                685
Thr Pro Gln Gln Gln Val Glu Leu Phe Asp Leu Glu Asn Asn Pro Glu 
     690                695                700
Tyr Val Ser Ser Gly Gly Gly Phe Gly Pro Val Ala Asp Asp Gly Tyr 
 705                710                715                720
Gly Val Ser Tyr Ile Leu Val Gly Glu Asn Leu Ile Asn Phe His Ile 
                 725                730                735
Ser Ser Lys Phe Ser Cys Pro Glu Thr Asp Ser His Arg Phe Gly Arg 
             740                745                750
His Leu Lys Glu Ala Met Thr Asp Ile Ile Thr Leu Phe Gly Leu Ser 
         755                760                765
Ser Asn Ser Lys Lys 
     770



<210> 2822
<211> 3665
<212> DNA
<213> Rattus norvegicus
<308> L07925
<400> 2822

ccaccaggc  taacaacta  aggaggctt  cggccctcg  aaaccacgc  cccatcagt  60
agtccccac  ctcagctga  atcagcgag  ccggccctg  gcgcagagc  caggcagcg  120
ggagccgcg  cggccggcc  tgcgcccac  ccgccccgg  tctcgcggc  cgccggcca  180
ccgcgccac  gggagtcgt  catggtgca  cgcatgtgg  ccgaggcgt  cgggcccat  240
gggggcgcc  agccgttgt  tcccggctc  cggcgcagc  gcagcgtgt  ggacgccgt  300
cgtctggag  tgggcgtcc  tgacagctg  ccagtggtg  tgcacagct  cacgcagct  360
gaccccgat  tgccgcgcc  ggagagctc  acgcaggag  ttggggagg  gctgatcaa  420
ggggtcatc  actccatct  cctgcgcaa  gttcagcta  acccaggag  caccaaggg  480
cagcgctgg  tagggtgcg  gaatgagtc  gctctgaac  tctacgaga  ttgcaaggt  540
cgcacggtg  aggccggta  tctggagaa  ctggtggaa  acctggtgc  tgccttcca  600
ggcagtgac  tttcctacg  caccgtatt  ctgtgcacc  acagagcct  cacaaccac  660
cagcaggtg  tagacctgc  gttcaaaag  tatggctgc  tccttccct  ctccagtga  720
gacggcgga  cacaggacc  actcaaaaa  gccatctct  ccatcctgg  cacctggct  780
gaccaatac  ccgaggact  ctgtcaacc  ccggacttt  cctgcctca  gcagctggt  840
gcttatgtg  agctcaaca  gcctggctc  gacctggag  gccgtgctc  ccttctcct  900
gcccagctg  aggacctgg  gcccagtga  gttgagcct  aggccctgt  cccagctcc  960
gtgctgtct  tgaaaccag  ttcacagct  gaaccagct  ccgccctgc  tctgacgcc  1020
agccgagct  tggcatcca  tccagtacg  gagccagcc  cggtgccag  actggcatc  1080
agcccggtg  tggcgccag  ctctgagct  gaaccagct  tggagccgc  cctagaccc  1140
gagccaacc  tcgcacctg  tccagagct  gaccccact  tctcacaga  cctccacct  1200
gagcccgct  ccgtgcccg  tcctgcatt  gagccttcc  ggcctctgc  tgaaaccac  1260
gagaacgga  tgtgtgcaa  gcctcacct  ctgctgttc  ctccagact  ggtggctga  1320
cagtttacg  tgatggacg  agagctatt  aagaaagtt  tgccctacc  ctgcctggg  1380
tccatctgg  cccagcggg  aaagaaggg  aaggagcac  tcgcgccca  catccgtgc  1440
actgtcgcc  agttcaaca  cgtggccaa  tgtgtcatc  ccacctgcc  tggggacca  1500
agtatgaaa  cttcggaca  ggcccgggt  gtggaacac  ggatcgagg  ggccaggga  1560
tgcagggtg  tcaagaatt  ctcctccct  tacgccatc  tctctgccc  acagagcaa  1620
gccatccac  gcctaaaga  gacatggga  gaggtctcc  ggggcagct  tcgagtgtt  1680
cagaaactg  cagaaatct  ctctgatga  aacaactac  ccttgagca  agagctgct  1740
atcaaggaa  gaacctcca  gtttgccac  ctggagatg  accctagga  aacccagag  1800
cggcagaag  agacaggtg  catccaggg  actgtcccc  acctgggca  attcctcac  1860
gacctggtg  tgctggaca  agccatgaa  gactatcta  atgggagac  gatcaactt  1920
gaaaagagg  ggaaggagt  cgaagtcat  gcccagatc  agttgctcc  gtcggcctg  1980
aacaactac  gcattgttc  cgaggagca  tttggagcc  ggttccgag  catgggacg  2040
ctcagcgag  ctgagagct  caacctgtc  tgtgagctg  agcccccgt  tgagtcagc  2100
agcaacacc  tgaggagca  gaaaagcac  gctatcgtc  agcgctggg  gcgacgcca  2160
gctcccagc  cggagctca  caccagtag  agtgcacac  ccaagtcat  tgaccagct  2220
cggtgcagc  cctacctca  cagcgggga  atcacggac  cactcagtg  gcactcagc  2280
ggttcatcc  cgtctgacg  ggaggagat  aacatgagc  ttgttccag  gtctcctga  2340
ggccaggaa  agaagttct  ggagtcagc  tcccagtcg  ccccagaga  ctctggcat  2400
agctcggcc  ccagcagca  ctcctcttc  tcagcctct  ccacaccgg  gtctaccac  2460
cgcacccac  agcgctctg  ctcaggggt  tgcagctac  gctcctcac  gccactcta  2520
aaccagcag  tgggcgact  ctgcatcat  agggtcagc  tggatgtgg  caacggcaa  2580
atgtacaag  gcatcctgg  gaccagcca  gataaggct  cgactgtca  ccggaaagc  2640
atggacaaa  acaacctag  tgaggacga  cccgaggac  atgagctgc  gcagatcat  2700
tcagaggac  acaagctga  aattccaga  aacgccaat  tgttctatg  catgaactc  2760
gccgccaac  atgacttca  cctaaagaa  cgggccttc  ctaaggggg  taaagtcaa  2820
catggagcc  gctccactc  ccctcgaat  aagcagaag  gactcagga  tgccagagg  2880
atcttctaa  gacgtctcc  aggggctgg  tggctggct  gggactaag  acttacaga  2940
tagagtggc  caggccaca  gtacctctg  cctcctgcc  gcccaggct  ctcccagac  3000
ccactttca  cccgaacct  tcctgctgc  gggattgac  cctgccact  acaggctga  3060
ctggcctcc  gggaccgct  accgcctta  gtgccttct  ctctctgca  ccagaggac  3120
agctgactt  gccaagggg  gctgccagc  gggcatgga  cctcgcctg  cctggacaa  3180
gtccaccac  ctttcctgt  acctcccca  gtgcagatc  ctgccaccc  tgctcccag  3240
tgctccagg  cacccacac  cccagcggg  ctgccaact  cgttctctc  ttgtgccca  3300
aggccatgg  ctgggacct  catggaggt  ctagccttt  ttaggctgc  ccaaagatt  3360
caccttcag  cctacagag  gagggagtc  cgcccacca  gagcccaag  cctcccatg  3420
atcagagag  gaagccctc  catggaccg  ctggttggc  ttgaacccc  taccactga  3480
agtgccatt  accaccgct  cgtcccggg  gtacaagac  acatgcaat  ggaggtttg  3540
ggggagggg  aagacgact  gatatttgt  taaaacgta  aaagtttac  gattggggt  3600
gggcaatat  tatttgttg  aaatagaaa  tgctagact  gaatattat  ttaaaatcc  3660
gtttc  3665



<210> 2823
<211> 895
<212> PRT
<213> Rattus norvegicus
<308> Q03386
<400> 2823

Met Val Gln Arg Met Trp Ala Glu Ala Ser Gly Pro Ile Gly Gly Ala 
  1               5                  10                  15
Glu Pro Leu Phe Pro Gly Ser Arg Arg Ser Arg Ser Val Trp Asp Ala 
             20                  25                  30
Val Arg Leu Glu Val Gly Val Pro Asp Ser Cys Pro Val Val Leu His 
         35                  40                  45
Ser Phe Thr Gln Leu Asp Pro Asp Leu Pro Arg Leu Glu Ser Ser Thr 
     50                  55                  60
Gln Glu Ile Gly Glu Glu Leu Ile Asn Gly Val Ile Tyr Ser Ile Ser 
 65                  70                  75                  80
Leu Arg Lys Val Gln Leu Tyr Pro Gly Ala Thr Lys Gly Gln Arg Trp 
                 85                  90                  95
Leu Gly Cys Glu Asn Glu Ser Ala Leu Asn Leu Tyr Glu Thr Cys Lys 
             100                105                110
Val Arg Thr Val Lys Ala Gly Thr Leu Glu Lys Leu Val Glu His Leu 
         115                120                125
Val Pro Ala Phe Gln Gly Ser Asp Leu Ser Tyr Val Thr Val Phe Leu 
     130                135                140
Cys Thr Tyr Arg Ala Phe Thr Thr Thr Gln Gln Val Leu Asp Leu Leu 
 145                150                155                160
Phe Lys Arg Tyr Gly Cys Ile Leu Pro Tyr Ser Ser Glu Asp Gly Gly 
                 165                170                175
Pro Gln Asp Gln Leu Lys Asn Ala Ile Ser Ser Ile Leu Gly Thr Trp 
             180                185                190
Leu Asp Gln Tyr Ser Glu Asp Phe Cys Gln Pro Pro Asp Phe Pro Cys 
         195                200                205
Leu Lys Gln Leu Val Ala Tyr Val Gln Leu Asn Met Pro Gly Ser Asp 
     210                215                220
Leu Glu Arg Arg Ala His Leu Leu Leu Ala Gln Leu Glu Asp Leu Glu 
 225                230                235                240
Pro Ser Glu Val Glu Pro Glu Ala Leu Ser Pro Ala Pro Val Leu Ser 
                 245                250                255
Leu Lys Pro Ala Ser Gln Leu Glu Pro Ala Pro Ala Leu Leu Leu Thr 
             260                265                270
Pro Ser Arg Ala Val Ala Ser Thr Pro Val Arg Glu Pro Ala Pro Val 
         275                280                285
Pro Val Leu Ala Ser Ser Pro Val Val Ala Pro Ala Ser Glu Leu Glu 
     290                295                300
Pro Ala Leu Glu Pro Pro Leu Asp Pro Glu Pro Thr Leu Ala Pro Ala 
 305                310                315                320
Pro Glu Leu Asp Pro Thr Val Ser Gln Ser Leu His Leu Glu Pro Ala 
                 325                330                335
Pro Val Pro Ala Pro Ala Leu Glu Pro Ser Trp Pro Leu Pro Glu Thr 
             340                345                350
Thr Glu Asn Gly Leu Cys Ala Lys Pro His Leu Leu Leu Phe Pro Pro 
         355                360                365
Asp Leu Val Ala Glu Gln Phe Thr Leu Met Asp Ala Glu Leu Phe Lys 
     370                375                380
Lys Val Val Pro Tyr His Cys Leu Gly Ser Ile Trp Ser Gln Arg Ala 
 385                390                395                400
Lys Lys Gly Lys Glu His Leu Ala Pro Thr Ile Arg Ala Thr Val Ala 
                 405                410                415
Gln Phe Asn Asn Val Ala Asn Cys Val Ile Thr Thr Cys Leu Gly Asp 
             420                425                430
Gln Ser Met Lys Ala Ser Asp Arg Ala Arg Val Val Glu His Trp Ile 
         435                440                445
Glu Val Ala Arg Glu Cys Arg Val Leu Lys Asn Phe Ser Ser Leu Tyr 
     450                455                460
Ala Ile Leu Ser Ala Leu Gln Ser Asn Ala Ile His Arg Leu Lys Lys 
 465                470                475                480
Thr Trp Glu Glu Val Ser Arg Gly Ser Phe Arg Val Phe Gln Lys Leu 
                 485                490                495
Ser Glu Ile Phe Ser Asp Glu Asn Asn Tyr Ser Leu Ser Arg Glu Leu 
             500                505                510
Leu Ile Lys Glu Gly Thr Ser Lys Phe Ala Thr Leu Glu Met Asn Pro 
         515                520                525
Arg Arg Thr Gln Arg Arg Gln Lys Glu Thr Gly Val Ile Gln Gly Thr 
     530                535                540
Val Pro Tyr Leu Gly Thr Phe Leu Thr Asp Leu Val Met Leu Asp Thr 
 545                550                555                560
Ala Met Lys Asp Tyr Leu Tyr Gly Arg Leu Ile Asn Phe Glu Lys Arg 
                 565                570                575
Arg Lys Glu Phe Glu Val Ile Ala Gln Ile Lys Leu Leu Gln Ser Ala 
             580                585                590
Cys Asn Asn Tyr Ser Ile Val Pro Glu Glu His Phe Gly Ala Trp Phe 
         595                600                605
Arg Ala Met Gly Arg Leu Ser Glu Ala Glu Ser Tyr Asn Leu Ser Cys 
     610                615                620
Glu Leu Glu Pro Pro Ser Glu Ser Ala Ser Asn Thr Leu Arg Ser Lys 
 625                630                635                640
Lys Ser Thr Ala Ile Val Lys Arg Trp Glu Arg Arg Gln Ala Pro Ser 
                 645                650                655
Thr Glu Leu Ser Thr Ser Ser Ser Ala His Ser Lys Ser Cys Asp Gln 
             660                665                670
Leu Arg Cys Ser Pro Tyr Leu Ser Ser Gly Asp Ile Thr Asp Ala Leu 
         675                680                685
Ser Val His Ser Ala Gly Ser Ser Thr Ser Asp Val Glu Glu Ile Asn 
     690                695                700
Met Ser Phe Val Pro Glu Ser Pro Asp Gly Gln Glu Lys Lys Phe Trp 
 705                710                715                720
Glu Ser Ala Ser Gln Ser Ser Pro Glu Thr Ser Gly Ile Ser Ser Ala 
                 725                730                735
Ser Ser Ser Thr Ser Ser Ser Ser Ala Ser Thr Thr Pro Val Ser Thr 
             740                745                750
Thr Arg Thr His Lys Arg Ser Val Ser Gly Val Cys Ser Tyr Ser Ser 
         755                760                765
Ser Leu Pro Leu Tyr Asn Gln Gln Val Gly Asp Cys Cys Ile Ile Arg 
     770                775                780
Val Ser Leu Asp Val Asp Asn Gly Asn Met Tyr Lys Ser Ile Leu Val 
 785                790                795                800
Thr Ser Gln Asp Lys Ala Pro Thr Val Ile Arg Lys Ala Met Asp Lys 
                 805                810                815
His Asn Leu Asp Glu Asp Glu Pro Glu Asp Tyr Glu Leu Leu Gln Ile 
             820                825                830
Ile Ser Glu Asp His Lys Leu Lys Ile Pro Glu Asn Ala Asn Val Phe 
         835                840                845
Tyr Ala Met Asn Ser Ala Ala Asn Tyr Asp Phe Ile Leu Lys Lys Arg 
     850                855                860
Ala Phe Thr Lys Gly Ala Lys Val Lys His Gly Ala Ser Ser Thr Leu 
 865                870                875                880
Pro Arg Met Lys Gln Lys Gly Leu Arg Ile Ala Arg Gly Ile Phe 
                 885                890                895



<210> 2824
<211> 5796
<212> DNA
<213> Homo sapiens
<308> AB037729
<400> 2824

ctggaccag  actcggagg  tttctgtca  cctccggac  ttccctgcc  caagcagct  60
gtggcctac  tgcagctca  catgccagg  tcagacctg  agcgccgtg  ccaccttct  120
ctggcccag  tggagcact  ggaacccat  gaggcagag  ctgaggctc  gtcaccagt  180
ccagctcta  aaccaactc  agagctcga  ctagctcta  caccagctc  agcacccag  240
ccagtgccg  ctccagccc  ggagccaga  ccagctcca  caccagctc  aggttcaga  300
ctagaagta  ctccagcac  agctccgga  ctccagcag  ctccagagc  agctgtggg  360
ctagaatcg  ctccagcgc  agctctgga  ctagagcca  ctccagaac  ggatccagc  420
ccctcacaa  ctctagagc  ggagccagc  ccagcacca  ttccatcat  acagccttc  480
tggccttca  ctgtggttg  agagaacgg  ctgagtgag  agaagcctc  cctcttggt  540
ttccctcca  atctggtgg  agagcagtt  acactgatg  atgcggaac  gttcaagaa  600
gtggtgccc  accactgcc  gggctccat  tggtcccag  gggacaaga  gggcaagga  660
cacctggcg  ccaccatcc  cgccactgt  acccagttc  acagtgtgg  caactgtgt  720
atcaccacc  gcctcggga  ccgaagcac  aaagcccca  acagggcca  ggtggtgga  780
cactggatc  aggtggcca  ggagtgccg  atcctcaag  acttctcgt  actgtatgc  840
atcctctct  ccctgcaga  caactccat  caccgtctg  agaagacgt  ggaagacgt  900
tccagggac  gtttccgga  ctttcagaa  ctgtcagag  tcttctcag  tgagaacaa  960
tactcattg  gccgggagc  gctcatcaa  gagggcacc  ccaagtttg  caccctgga  1020
atgaacccc  agagagccc  gaaacggcc  aaggagacg  gcatcatcc  gggcaccgt  1080
ccctacctg  gcacgttcc  caccgacct  gtgatgctg  acactgcca  gaaggacta  1140
ctgtatggc  gactcatca  ctttgagaa  aggaggaag  agttcgagg  gatcgccca  1200
atcaagctg  tgcagtcgg  ctgcaacaa  tacagcatc  cgccagatg  gcaatttgg  1260
gcctggttc  gggccgtgg  gcggctcag  gagactgag  gctacaacc  gtcgtgcga  1320
ctggagccc  catccgagt  agccagcaa  accctcagg  ccaagaaga  cacagccat  1380
gtcaagcgc  ggagcgacc  ccaggcccc  agcactgag  tcagtacca  tggcagctc  1440
cactccaag  cctgtgacc  gctcaggtg  ggcccctac  tcagcagcg  ggacatcgc  1500
gacgcgctc  gcgtgcact  ggccggctc  tctagctcc  acgtggagg  gatcaacat  1560
agcttcgtc  cggagtctc  tgatggcca  gaaaagaag  tgactgcct  cccttctcc  1620
caatatcct  tcccatctc  ccactccaa  tccatgcat  gggccagga  gccctggat  1680
ctgaacaca  cttctagaa  gttccccat  tggcagctg  cctggggtg  ccccacagg  1740
cagtgggat  tgctgatct  accgtctcc  tcagttctg  gaatcagcc  cacagtcat  1800
cccggagac  tccggcatc  gctcagcct  cagcagcac  tcgtcctcc  cagcctcca  1860
cacgcccgt  gctgccaca  gcacccaca  gcgctctgt  tcagggctc  gcaactcca  1920
ctccgcgct  ccgctctac  accagcagg  gggcgactg  tgtatcatc  gcgtcagcc  1980
ggacgtgga  aatggcaac  tgtacaaga  catcctggt  agccggcgg  ggtggcctg  2040
gtgcctccc  ccactggcg  caaatgcac  ctgaacaca  tgcaccatc  ctgccctcc  2100
ggggtctac  ttgtagttg  cggggaagg  cagatgtca  ccaggtaca  aaatgaaga  2160
ggtagtgat  agggacaag  ctggcctga  ggcagaggg  gaggaaagg  gcagccgtg  2220
aaagccccc  ggagctgaa  gggcggtgc  gtaggggag  tgaggtcag  gaagtatcc  2280
gggcctggc  acataggcc  tgagccctg  caggacctc  actttctcg  ggaggaaga  2340
aggagcaat  atggctggc  tctctgtct  gcgtgggct  gtaccagag  cgcaggggt  2400
ttggttagg  ggccgctgt  gcaaccagg  tgggagccc  ggaaggggc  agcagggtc  2460
gagtctaga  aggatttgg  gacagcaga  gggaattgc  cacagaatg  gtttgcctg  2520
gggctcttt  ttcatcctc  aggtgtcct  cgacagatg  accatttgt  acccccacc  2580
tctgtaccc  agccctggg  caggtgccc  attattcac  cacgctcct  acccctcat  2640
gccaggagc  agcatggtt  tcattaagc  gtcacctgt  gccctatgt  cgagttccg  2700
ctgtgctct  gccctcagg  tcaaggtag  aggggcctg  cctatgctg  ccacactga  2760
catcctggc  ggcccctcc  ttcttacct  cagggcttg  actagggac  gtctgttcc  2820
caggctcag  gatgctgtt  tcctggagg  gcaagtgct  ctcaaggaa  tgtgggagg  2880
gggaacagt  tcttacagg  gaagcaggg  aggcactgc  gggacagac  cctcctcat  2940
ccatggagg  ctcacatgg  gaacagaag  acggaggcc  cacttgggg  gtaggagaa  3000
gtgacaagg  cctctccgg  cccagcacc  ggccagagg  tgtgagtgc  tgtgcttgg  3060
gctgagggg  ctccagagg  tccttggcc  ctgcactct  ggggagccg  tccagggtc  3120
tttccctga  ggtccatcc  ccgccgcga  gcaggtgac  agccaagat  aggctccgg  3180
tgtaatccg  aaggccatg  acaaacaca  cctggagga  gaggagccg  aggactatg  3240
gctgctgca  attctctca  atgaccgga  taagtcaga  gaccagagg  cgatggcag  3300
gggggcagg  ccacaccac  ccccagccc  aggttggaa  cctttggcc  cagaaaatt  3360
accagcaga  tgtgggtag  cactgtgga  agggcagcc  tggctgccc  cattgtctg  3420
ttgctgtcc  cagcaacca  tggacctcc  cagtgtgtg  ccttcccta  gcgtgaaca  3480
gcagttcaa  gctcacatc  gtgaggagc  aagagaaaa  gcatttttc  ctgggacag  3540
ttagccacg  ggcccactg  aagggacgc  ttctggcta  gacaagaaa  catgtgctc  3600
acaaagaat  gtgacagct  tggaccaaa  tgtcaagtg  taaaatcca  gagtgtgtg  3660
ttctaaaag  agaacaggc  actaggagg  caactcagt  ttctagaaa  tgggaaagt  3720
tcaagaacc  gtgcaggct  agagtgggg  atcctgggc  tggagacgc  gggcaagct  3780
cttaagccc  ctgtgcttg  cttctcatc  cccaaatgg  aatgaaagt  gccagtgtg  3840
tcatcatat  tgtaaaaat  tatatgtat  tatatatgt  tatatatat  catgtatat  3900
tgtgtgtat  tatatgcat  tatatgtgt  tgtatatat  tgcatgtat  tataaagca  3960
ctatgtgca  cataaaagt  aactataaa  actatcatc  ctgttttct  tccagtgag  4020
tgaacacca  ctcccacca  tagcccaga  agtaagcaa  gactcctgt  atccctaga  4080
gttacagtc  aaatcctct  gcagcttct  gcaccattt  ggttaggtg  gcagggtag  4140
cgggacccc  atcttacag  aaaggaaga  tgaggccta  agaggttaa  gatgacgaa  4200
agccacacg  tgtcggcag  agcacaaat  gagcccagc  ctggtttat  gcaggctgt  4260
ggccagagg  gatggtggg  aatggagcc  aaaggaagt  cttgccggg  gccagggtt  4320
aaggagtac  ggcctccct  gaacgggcg  cagagccct  gggcaggcc  gtcctttcc  4380
ggtccttgg  tcccttgtc  tgagtaggg  aggattctg  gaggtgacc  ggattctag  4440
aagcctgtt  caggtgggc  gccagcact  cagtatggg  aggacgggg  gaccctctg  4500
cagctcagg  caagccggg  ggttctgga  tcagtccct  tttaaacaa  agtcatcag  4560
ttttgtgag  acctcagca  agtctgtcc  caggcagga  tcattgaga  gggtccttg  4620
agttctgga  ctgtattgg  ggggatctg  ggtctgtgg  tcaagacag  ccttgtatg  4680
gctctcaag  ggtaggggt  tcctgcagg  cccccagga  catccctga  cacccctct  4740
cccctcccc  ccagagctg  agatccctg  aaacgccaa  gtcttctat  ccatgaact  4800
tactgccaa  tatgacttt  tcctgaaga  gcggacctt  accaaggga  tgaaggtca  4860
gcacggagc  agctccacc  tccctcgca  gaagcagaa  ggactcaag  ttgccaagg  4920
catcttctg  gggcatcct  ccagggtct  gctggctgg  agccaagca  ttatggacc  4980
gagtggccc  ggccagctg  gcgccttcc  cccacctgc  agcccaggg  accccagac  5040
ccagtttca  cctgaacct  tcccgctgc  gggattgac  cctgccatt  gtcaggctg  5100
cctggcctc  cgtggacca  tcgctgcct  aggtgcctt  tgctctctg  aaccagagg  5160
ctagctgac  tttgccaag  agcagtgcc  acgggcatg  catggtgcc  tgcctgccc  5220
cgggcgcca  ctctgtaca  ttccctgac  ccttcccag  tgtgggtca  tgccacctg  5280
gcccatggg  accccagag  acccactgt  accactgca  ttctctcat  cccacaggc  5340
ctggcctgt  accttcgca  gggtcccgg  ccctcccac  actctagcc  ttctcaggc  5400
gcaccaaag  ttccatcat  agggccaac  gagagtgag  gagtctcac  caccgctta  5460
cccagccct  ccctgggag  agagagaga  accctcttc  tggaccaga  tctgcaccc  5520
gtgagtgag  acagtccca  ctgagtccc  tcgatgttg  atctcatgc  actgcaagt  5580
ccattcacc  ctgcgtcct  ggctttacg  gaccatgca  gacgggggt  agtgaggaa  5640
gaggatttg  ggtgggggt  gggtgattg  atatttgta  aaaaagcaa  aagaaaaaa  5700
aaatgtttg  ttactgatt  gggaggggc  atatttatt  gttgtaaat  gcaaatgct  5760
gacttgaat  ttatattaa  atcctgttt  tactat  5796



<210> 2825
<211> 914
<212> PRT
<213> Homo sapiens
<308> Q12967
<400> 2825

Met Val Gln Arg Met Trp Ala Glu Ala Ala Gly Pro Ala Gly Gly Ala 
  1               5                  10                  15
Glu Pro Leu Phe Pro Gly Ser Arg Arg Ser Arg Ser Val Trp Asp Ala 
             20                  25                  30
Val Arg Leu Glu Val Gly Val Pro Asp Ser Cys Pro Val Val Leu His 
         35                  40                  45
Ser Phe Thr Gln Leu Asp Pro Asp Leu Pro Arg Pro Glu Ser Ser Thr 
     50                  55                  60
Gln Glu Ile Gly Glu Glu Leu Ile Asn Gly Val Ile Tyr Ser Ile Ser 
 65                  70                  75                  80
Leu Arg Lys Val Gln Leu His His Gly Gly Asn Lys Gly Gln Arg Trp 
                 85                  90                  95
Leu Gly Tyr Glu Asn Glu Ser Ala Leu Asn Leu Tyr Glu Thr Cys Lys 
             100                105                110
Val Arg Thr Val Lys Ala Gly Thr Leu Glu Lys Leu Val Glu His Leu 
         115                120                125
Val Pro Ala Phe Gln Gly Ser Asp Leu Ser Tyr Val Thr Ile Phe Leu 
     130                135                140
Cys Thr Tyr Arg Ala Phe Thr Thr Thr Gln Gln Val Leu Asp Leu Leu 
 145                150                155                160
Phe Lys Arg Tyr Gly Arg Cys Asp Ala Leu Thr Ala Ser Ser Arg Tyr 
                 165                170                175
Gly Cys Ile Leu Pro Tyr Ser Asp Glu Asp Gly Gly Pro Gln Asp Gln 
             180                185                190
Leu Lys Asn Ala Ile Ser Ser Ile Leu Gly Thr Trp Leu Asp Gln Tyr 
         195                200                205
Ser Glu Asp Phe Cys Gln Pro Pro Asp Phe Pro Cys Leu Lys Gln Leu 
     210                215                220
Val Ala Tyr Val Gln Leu Asn Met Pro Gly Ser Asp Leu Glu Arg Arg 
 225                230                235                240
Ala His Leu Leu Leu Ala Gln Leu Glu His Ser Glu Pro Ile Glu Ala 
                 245                250                255
Glu Pro Glu Ala Leu Ser Pro Val Pro Ala Leu Lys Pro Thr Pro Glu 
             260                265                270
Leu Glu Leu Ala Leu Thr Pro Ala Arg Ala Pro Ser Pro Val Pro Ala 
         275                280                285
Pro Ala Pro Glu Pro Glu Pro Ala Pro Thr Pro Ala Pro Gly Ser Glu 
     290                295                300
Leu Glu Val Ala Pro Ala Pro Ala Pro Glu Leu Gln Gln Ala Pro Glu 
 305                310                315                320
Pro Ala Val Gly Leu Glu Ser Ala Pro Ala Pro Ala Leu Glu Leu Glu 
                 325                330                335
Pro Ala Pro Glu Gln Asp Pro Ala Pro Ser Gln Thr Leu Glu Leu Glu 
             340                345                350
Pro Ala Pro Ala Pro Val Pro Ser Leu Gln Pro Ser Trp Pro Ser Pro 
         355                360                365
Val Val Ala Glu Asn Gly Leu Ser Glu Glu Lys Pro His Leu Leu Val 
     370                375                380
Phe Pro Pro Asp Leu Val Ala Glu Gln Phe Thr Leu Met Asp Ala Glu 
 385                390                395                400
Leu Phe Lys Lys Val Val Pro Tyr His Cys Leu Gly Ser Ile Trp Ser 
                 405                410                415
Gln Arg Asp Lys Lys Gly Lys Glu His Leu Ala Pro Thr Ile Arg Ala 
             420                425                430
Thr Val Thr Gln Phe Asn Ser Val Ala Asn Cys Val Ile Thr Thr Cys 
         435                440                445
Leu Gly Asn Arg Ser Thr Lys Ala Pro Asp Arg Ala Arg Val Val Glu 
     450                455                460
His Trp Ile Glu Val Ala Arg Glu Cys Arg Ile Leu Lys Asn Phe Ser 
 465                470                475                480
Ser Leu Tyr Ala Ile Leu Ser Ala Leu Gln Ser Asn Ser Ile His Arg 
                 485                490                495
Leu Lys Lys Thr Trp Glu Asp Val Ser Arg Asp Ser Phe Arg Ile Phe 
             500                505                510
Gln Lys Leu Ser Glu Ile Phe Ser Asp Glu Asn Asn Tyr Ser Leu Ser 
         515                520                525
Arg Glu Leu Leu Ile Lys Glu Gly Thr Ser Lys Phe Ala Thr Leu Glu 
     530                535                540
Met Asn Pro Lys Arg Ala Gln Lys Arg Pro Lys Glu Thr Gly Ile Ile 
 545                550                555                560
Gln Gly Thr Val Pro Tyr Leu Gly Thr Phe Leu Thr Asp Leu Val Met 
                 565                570                575
Leu Asp Thr Ala Met Lys Asp Tyr Leu Tyr Gly Arg Leu Ile Asn Phe 
             580                585                590
Glu Lys Arg Arg Lys Glu Phe Glu Val Ile Ala Gln Ile Lys Leu Leu 
         595                600                605
Gln Ser Ala Cys Asn Asn Tyr Ser Ile Ala Pro Asp Glu Gln Phe Gly 
     610                615                620
Ala Trp Phe Arg Ala Val Glu Arg Leu Ser Glu Thr Glu Ser Tyr Asn 
 625                630                635                640
Leu Ser Cys Glu Leu Glu Pro Pro Ser Glu Ser Ala Ser Asn Thr Leu 
                 645                650                655
Arg Thr Lys Lys Asn Thr Ala Ile Val Lys Arg Trp Ser Asp Arg Gln 
             660                665                670
Ala Pro Ser Thr Glu Leu Ser Thr Ser Gly Ser Ser His Ser Lys Ser 
         675                680                685
Cys Asp Gln Leu Arg Cys Gly Pro Tyr Leu Ser Ser Gly Asp Ile Ala 
     690                695                700
Asp Ala Leu Ser Val His Ser Ala Gly Ser Ser Ser Ser Asp Val Glu 
 705                710                715                720
Glu Ile Asn Ile Ser Phe Val Pro Glu Ser Pro Asp Gly Gln Glu Lys 
                 725                730                735
Lys Phe Trp Glu Ser Ala Ser Gln Ser Ser Pro Glu Thr Ser Gly Ile 
             740                745                750
Ser Ser Ala Ser Ser Ser Thr Ser Ser Ser Ser Ala Ser Thr Thr Pro 
         755                760                765
Val Ala Ala Thr Arg Thr His Lys Arg Ser Val Ser Gly Leu Cys Asn 
     770                775                780
Ser Ser Ser Ala Leu Pro Leu Tyr Asn Gln Gln Val Gly Asp Cys Cys 
 785                790                795                800
Ile Ile Arg Val Ser Leu Asp Val Asp Asn Gly Asn Met Tyr Lys Ser 
                 805                810                815
Ile Leu Val Thr Ser Gln Asp Lys Ala Pro Ala Val Ile Arg Lys Ala 
             820                825                830
Met Asp Lys His Asn Leu Glu Glu Glu Glu Pro Glu Asp Tyr Glu Leu 
         835                840                845
Leu Gln Ile Leu Ser Asp Asp Arg Lys Leu Lys Ile Pro Glu Asn Ala 
     850                855                860
Asn Val Phe Tyr Ala Met Asn Ser Thr Ala Asn Tyr Asp Phe Val Leu 
 865                870                875                880
Lys Lys Arg Thr Phe Thr Lys Gly Val Lys Val Lys His Gly Ala Ser 
                 885                890                895
Ser Thr Leu Pro Arg Met Lys Gln Lys Gly Leu Lys Ile Ala Lys Gly 
             900                905                910
Ile Phe 
         915



<210> 2826
<211> 3665
<212> DNA
<213> Rattus norvegicus
<308> L07925
<400> 2826

ccaccaggc  taacaacta  aggaggctt  cggccctcg  aaaccacgc  cccatcagt  60
agtccccac  ctcagctga  atcagcgag  ccggccctg  gcgcagagc  caggcagcg  120
ggagccgcg  cggccggcc  tgcgcccac  ccgccccgg  tctcgcggc  cgccggcca  180
ccgcgccac  gggagtcgt  catggtgca  cgcatgtgg  ccgaggcgt  cgggcccat  240
gggggcgcc  agccgttgt  tcccggctc  cggcgcagc  gcagcgtgt  ggacgccgt  300
cgtctggag  tgggcgtcc  tgacagctg  ccagtggtg  tgcacagct  cacgcagct  360
gaccccgat  tgccgcgcc  ggagagctc  acgcaggag  ttggggagg  gctgatcaa  420
ggggtcatc  actccatct  cctgcgcaa  gttcagcta  acccaggag  caccaaggg  480
cagcgctgg  tagggtgcg  gaatgagtc  gctctgaac  tctacgaga  ttgcaaggt  540
cgcacggtg  aggccggta  tctggagaa  ctggtggaa  acctggtgc  tgccttcca  600
ggcagtgac  tttcctacg  caccgtatt  ctgtgcacc  acagagcct  cacaaccac  660
cagcaggtg  tagacctgc  gttcaaaag  tatggctgc  tccttccct  ctccagtga  720
gacggcgga  cacaggacc  actcaaaaa  gccatctct  ccatcctgg  cacctggct  780
gaccaatac  ccgaggact  ctgtcaacc  ccggacttt  cctgcctca  gcagctggt  840
gcttatgtg  agctcaaca  gcctggctc  gacctggag  gccgtgctc  ccttctcct  900
gcccagctg  aggacctgg  gcccagtga  gttgagcct  aggccctgt  cccagctcc  960
gtgctgtct  tgaaaccag  ttcacagct  gaaccagct  ccgccctgc  tctgacgcc  1020
agccgagct  tggcatcca  tccagtacg  gagccagcc  cggtgccag  actggcatc  1080
agcccggtg  tggcgccag  ctctgagct  gaaccagct  tggagccgc  cctagaccc  1140
gagccaacc  tcgcacctg  tccagagct  gaccccact  tctcacaga  cctccacct  1200
gagcccgct  ccgtgcccg  tcctgcatt  gagccttcc  ggcctctgc  tgaaaccac  1260
gagaacgga  tgtgtgcaa  gcctcacct  ctgctgttc  ctccagact  ggtggctga  1320
cagtttacg  tgatggacg  agagctatt  aagaaagtt  tgccctacc  ctgcctggg  1380
tccatctgg  cccagcggg  aaagaaggg  aaggagcac  tcgcgccca  catccgtgc  1440
actgtcgcc  agttcaaca  cgtggccaa  tgtgtcatc  ccacctgcc  tggggacca  1500
agtatgaaa  cttcggaca  ggcccgggt  gtggaacac  ggatcgagg  ggccaggga  1560
tgcagggtg  tcaagaatt  ctcctccct  tacgccatc  tctctgccc  acagagcaa  1620
gccatccac  gcctaaaga  gacatggga  gaggtctcc  ggggcagct  tcgagtgtt  1680
cagaaactg  cagaaatct  ctctgatga  aacaactac  ccttgagca  agagctgct  1740
atcaaggaa  gaacctcca  gtttgccac  ctggagatg  accctagga  aacccagag  1800
cggcagaag  agacaggtg  catccaggg  actgtcccc  acctgggca  attcctcac  1860
gacctggtg  tgctggaca  agccatgaa  gactatcta  atgggagac  gatcaactt  1920
gaaaagagg  ggaaggagt  cgaagtcat  gcccagatc  agttgctcc  gtcggcctg  1980
aacaactac  gcattgttc  cgaggagca  tttggagcc  ggttccgag  catgggacg  2040
ctcagcgag  ctgagagct  caacctgtc  tgtgagctg  agcccccgt  tgagtcagc  2100
agcaacacc  tgaggagca  gaaaagcac  gctatcgtc  agcgctggg  gcgacgcca  2160
gctcccagc  cggagctca  caccagtag  agtgcacac  ccaagtcat  tgaccagct  2220
cggtgcagc  cctacctca  cagcgggga  atcacggac  cactcagtg  gcactcagc  2280
ggttcatcc  cgtctgacg  ggaggagat  aacatgagc  ttgttccag  gtctcctga  2340
ggccaggaa  agaagttct  ggagtcagc  tcccagtcg  ccccagaga  ctctggcat  2400
agctcggcc  ccagcagca  ctcctcttc  tcagcctct  ccacaccgg  gtctaccac  2460
cgcacccac  agcgctctg  ctcaggggt  tgcagctac  gctcctcac  gccactcta  2520
aaccagcag  tgggcgact  ctgcatcat  agggtcagc  tggatgtgg  caacggcaa  2580
atgtacaag  gcatcctgg  gaccagcca  gataaggct  cgactgtca  ccggaaagc  2640
atggacaaa  acaacctag  tgaggacga  cccgaggac  atgagctgc  gcagatcat  2700
tcagaggac  acaagctga  aattccaga  aacgccaat  tgttctatg  catgaactc  2760
gccgccaac  atgacttca  cctaaagaa  cgggccttc  ctaaggggg  taaagtcaa  2820
catggagcc  gctccactc  ccctcgaat  aagcagaag  gactcagga  tgccagagg  2880
atcttctaa  gacgtctcc  aggggctgg  tggctggct  gggactaag  acttacaga  2940
tagagtggc  caggccaca  gtacctctg  cctcctgcc  gcccaggct  ctcccagac  3000
ccactttca  cccgaacct  tcctgctgc  gggattgac  cctgccact  acaggctga  3060
ctggcctcc  gggaccgct  accgcctta  gtgccttct  ctctctgca  ccagaggac  3120
agctgactt  gccaagggg  gctgccagc  gggcatgga  cctcgcctg  cctggacaa  3180
gtccaccac  ctttcctgt  acctcccca  gtgcagatc  ctgccaccc  tgctcccag  3240
tgctccagg  cacccacac  cccagcggg  ctgccaact  cgttctctc  ttgtgccca  3300
aggccatgg  ctgggacct  catggaggt  ctagccttt  ttaggctgc  ccaaagatt  3360
caccttcag  cctacagag  gagggagtc  cgcccacca  gagcccaag  cctcccatg  3420
atcagagag  gaagccctc  catggaccg  ctggttggc  ttgaacccc  taccactga  3480
agtgccatt  accaccgct  cgtcccggg  gtacaagac  acatgcaat  ggaggtttg  3540
ggggagggg  aagacgact  gatatttgt  taaaacgta  aaagtttac  gattggggt  3600
gggcaatat  tatttgttg  aaatagaaa  tgctagact  gaatattat  ttaaaatcc  3660
gtttc  3665



<210> 2827
<211> 895
<212> PRT
<213> Rattus norvegicus
<308> Q03386
<400> 2827

Met Val Gln Arg Met Trp Ala Glu Ala Ser Gly Pro Ile Gly Gly Ala 
  1               5                  10                  15
Glu Pro Leu Phe Pro Gly Ser Arg Arg Ser Arg Ser Val Trp Asp Ala 
             20                  25                  30
Val Arg Leu Glu Val Gly Val Pro Asp Ser Cys Pro Val Val Leu His 
         35                  40                  45
Ser Phe Thr Gln Leu Asp Pro Asp Leu Pro Arg Leu Glu Ser Ser Thr 
     50                  55                  60
Gln Glu Ile Gly Glu Glu Leu Ile Asn Gly Val Ile Tyr Ser Ile Ser 
 65                  70                  75                  80
Leu Arg Lys Val Gln Leu Tyr Pro Gly Ala Thr Lys Gly Gln Arg Trp 
                 85                  90                  95
Leu Gly Cys Glu Asn Glu Ser Ala Leu Asn Leu Tyr Glu Thr Cys Lys 
             100                105                110
Val Arg Thr Val Lys Ala Gly Thr Leu Glu Lys Leu Val Glu His Leu 
         115                120                125
Val Pro Ala Phe Gln Gly Ser Asp Leu Ser Tyr Val Thr Val Phe Leu 
     130                135                140
Cys Thr Tyr Arg Ala Phe Thr Thr Thr Gln Gln Val Leu Asp Leu Leu 
 145                150                155                160
Phe Lys Arg Tyr Gly Cys Ile Leu Pro Tyr Ser Ser Glu Asp Gly Gly 
                 165                170                175
Pro Gln Asp Gln Leu Lys Asn Ala Ile Ser Ser Ile Leu Gly Thr Trp 
             180                185                190
Leu Asp Gln Tyr Ser Glu Asp Phe Cys Gln Pro Pro Asp Phe Pro Cys 
         195                200                205
Leu Lys Gln Leu Val Ala Tyr Val Gln Leu Asn Met Pro Gly Ser Asp 
     210                215                220
Leu Glu Arg Arg Ala His Leu Leu Leu Ala Gln Leu Glu Asp Leu Glu 
 225                230                235                240
Pro Ser Glu Val Glu Pro Glu Ala Leu Ser Pro Ala Pro Val Leu Ser 
                 245                250                255
Leu Lys Pro Ala Ser Gln Leu Glu Pro Ala Pro Ala Leu Leu Leu Thr 
             260                265                270
Pro Ser Arg Ala Val Ala Ser Thr Pro Val Arg Glu Pro Ala Pro Val 
         275                280                285
Pro Val Leu Ala Ser Ser Pro Val Val Ala Pro Ala Ser Glu Leu Glu 
     290                295                300
Pro Ala Leu Glu Pro Pro Leu Asp Pro Glu Pro Thr Leu Ala Pro Ala 
 305                310                315                320
Pro Glu Leu Asp Pro Thr Val Ser Gln Ser Leu His Leu Glu Pro Ala 
                 325                330                335
Pro Val Pro Ala Pro Ala Leu Glu Pro Ser Trp Pro Leu Pro Glu Thr 
             340                345                350
Thr Glu Asn Gly Leu Cys Ala Lys Pro His Leu Leu Leu Phe Pro Pro 
         355                360                365
Asp Leu Val Ala Glu Gln Phe Thr Leu Met Asp Ala Glu Leu Phe Lys 
     370                375                380
Lys Val Val Pro Tyr His Cys Leu Gly Ser Ile Trp Ser Gln Arg Ala 
 385                390                395                400
Lys Lys Gly Lys Glu His Leu Ala Pro Thr Ile Arg Ala Thr Val Ala 
                 405                410                415
Gln Phe Asn Asn Val Ala Asn Cys Val Ile Thr Thr Cys Leu Gly Asp 
             420                425                430
Gln Ser Met Lys Ala Ser Asp Arg Ala Arg Val Val Glu His Trp Ile 
         435                440                445
Glu Val Ala Arg Glu Cys Arg Val Leu Lys Asn Phe Ser Ser Leu Tyr 
     450                455                460
Ala Ile Leu Ser Ala Leu Gln Ser Asn Ala Ile His Arg Leu Lys Lys 
 465                470                475                480
Thr Trp Glu Glu Val Ser Arg Gly Ser Phe Arg Val Phe Gln Lys Leu 
                 485                490                495
Ser Glu Ile Phe Ser Asp Glu Asn Asn Tyr Ser Leu Ser Arg Glu Leu 
             500                505                510
Leu Ile Lys Glu Gly Thr Ser Lys Phe Ala Thr Leu Glu Met Asn Pro 
         515                520                525
Arg Arg Thr Gln Arg Arg Gln Lys Glu Thr Gly Val Ile Gln Gly Thr 
     530                535                540
Val Pro Tyr Leu Gly Thr Phe Leu Thr Asp Leu Val Met Leu Asp Thr 
 545                550                555                560
Ala Met Lys Asp Tyr Leu Tyr Gly Arg Leu Ile Asn Phe Glu Lys Arg 
                 565                570                575
Arg Lys Glu Phe Glu Val Ile Ala Gln Ile Lys Leu Leu Gln Ser Ala 
             580                585                590
Cys Asn Asn Tyr Ser Ile Val Pro Glu Glu His Phe Gly Ala Trp Phe 
         595                600                605
Arg Ala Met Gly Arg Leu Ser Glu Ala Glu Ser Tyr Asn Leu Ser Cys 
     610                615                620
Glu Leu Glu Pro Pro Ser Glu Ser Ala Ser Asn Thr Leu Arg Ser Lys 
 625                630                635                640
Lys Ser Thr Ala Ile Val Lys Arg Trp Glu Arg Arg Gln Ala Pro Ser 
                 645                650                655
Thr Glu Leu Ser Thr Ser Ser Ser Ala His Ser Lys Ser Cys Asp Gln 
             660                665                670
Leu Arg Cys Ser Pro Tyr Leu Ser Ser Gly Asp Ile Thr Asp Ala Leu 
         675                680                685
Ser Val His Ser Ala Gly Ser Ser Thr Ser Asp Val Glu Glu Ile Asn 
     690                695                700
Met Ser Phe Val Pro Glu Ser Pro Asp Gly Gln Glu Lys Lys Phe Trp 
 705                710                715                720
Glu Ser Ala Ser Gln Ser Ser Pro Glu Thr Ser Gly Ile Ser Ser Ala 
                 725                730                735
Ser Ser Ser Thr Ser Ser Ser Ser Ala Ser Thr Thr Pro Val Ser Thr 
             740                745                750
Thr Arg Thr His Lys Arg Ser Val Ser Gly Val Cys Ser Tyr Ser Ser 
         755                760                765
Ser Leu Pro Leu Tyr Asn Gln Gln Val Gly Asp Cys Cys Ile Ile Arg 
     770                775                780
Val Ser Leu Asp Val Asp Asn Gly Asn Met Tyr Lys Ser Ile Leu Val 
 785                790                795                800
Thr Ser Gln Asp Lys Ala Pro Thr Val Ile Arg Lys Ala Met Asp Lys 
                 805                810                815
His Asn Leu Asp Glu Asp Glu Pro Glu Asp Tyr Glu Leu Leu Gln Ile 
             820                825                830
Ile Ser Glu Asp His Lys Leu Lys Ile Pro Glu Asn Ala Asn Val Phe 
         835                840                845
Tyr Ala Met Asn Ser Ala Ala Asn Tyr Asp Phe Ile Leu Lys Lys Arg 
     850                855                860
Ala Phe Thr Lys Gly Ala Lys Val Lys His Gly Ala Ser Ser Thr Leu 
 865                870                875                880
Pro Arg Met Lys Gln Lys Gly Leu Arg Ile Ala Arg Gly Ile Phe 
                 885                890                895



<210> 2828
<211> 5796
<212> DNA
<213> Homo sapiens
<308> AB037729
<400> 2828

ctggaccag  actcggagg  tttctgtca  cctccggac  ttccctgcc  caagcagct  60
gtggcctac  tgcagctca  catgccagg  tcagacctg  agcgccgtg  ccaccttct  120
ctggcccag  tggagcact  ggaacccat  gaggcagag  ctgaggctc  gtcaccagt  180
ccagctcta  aaccaactc  agagctcga  ctagctcta  caccagctc  agcacccag  240
ccagtgccg  ctccagccc  ggagccaga  ccagctcca  caccagctc  aggttcaga  300
ctagaagta  ctccagcac  agctccgga  ctccagcag  ctccagagc  agctgtggg  360
ctagaatcg  ctccagcgc  agctctgga  ctagagcca  ctccagaac  ggatccagc  420
ccctcacaa  ctctagagc  ggagccagc  ccagcacca  ttccatcat  acagccttc  480
tggccttca  ctgtggttg  agagaacgg  ctgagtgag  agaagcctc  cctcttggt  540
ttccctcca  atctggtgg  agagcagtt  acactgatg  atgcggaac  gttcaagaa  600
gtggtgccc  accactgcc  gggctccat  tggtcccag  gggacaaga  gggcaagga  660
cacctggcg  ccaccatcc  cgccactgt  acccagttc  acagtgtgg  caactgtgt  720
atcaccacc  gcctcggga  ccgaagcac  aaagcccca  acagggcca  ggtggtgga  780
cactggatc  aggtggcca  ggagtgccg  atcctcaag  acttctcgt  actgtatgc  840
atcctctct  ccctgcaga  caactccat  caccgtctg  agaagacgt  ggaagacgt  900
tccagggac  gtttccgga  ctttcagaa  ctgtcagag  tcttctcag  tgagaacaa  960
tactcattg  gccgggagc  gctcatcaa  gagggcacc  ccaagtttg  caccctgga  1020
atgaacccc  agagagccc  gaaacggcc  aaggagacg  gcatcatcc  gggcaccgt  1080
ccctacctg  gcacgttcc  caccgacct  gtgatgctg  acactgcca  gaaggacta  1140
ctgtatggc  gactcatca  ctttgagaa  aggaggaag  agttcgagg  gatcgccca  1200
atcaagctg  tgcagtcgg  ctgcaacaa  tacagcatc  cgccagatg  gcaatttgg  1260
gcctggttc  gggccgtgg  gcggctcag  gagactgag  gctacaacc  gtcgtgcga  1320
ctggagccc  catccgagt  agccagcaa  accctcagg  ccaagaaga  cacagccat  1380
gtcaagcgc  ggagcgacc  ccaggcccc  agcactgag  tcagtacca  tggcagctc  1440
cactccaag  cctgtgacc  gctcaggtg  ggcccctac  tcagcagcg  ggacatcgc  1500
gacgcgctc  gcgtgcact  ggccggctc  tctagctcc  acgtggagg  gatcaacat  1560
agcttcgtc  cggagtctc  tgatggcca  gaaaagaag  tgactgcct  cccttctcc  1620
caatatcct  tcccatctc  ccactccaa  tccatgcat  gggccagga  gccctggat  1680
ctgaacaca  cttctagaa  gttccccat  tggcagctg  cctggggtg  ccccacagg  1740
cagtgggat  tgctgatct  accgtctcc  tcagttctg  gaatcagcc  cacagtcat  1800
cccggagac  tccggcatc  gctcagcct  cagcagcac  tcgtcctcc  cagcctcca  1860
cacgcccgt  gctgccaca  gcacccaca  gcgctctgt  tcagggctc  gcaactcca  1920
ctccgcgct  ccgctctac  accagcagg  gggcgactg  tgtatcatc  gcgtcagcc  1980
ggacgtgga  aatggcaac  tgtacaaga  catcctggt  agccggcgg  ggtggcctg  2040
gtgcctccc  ccactggcg  caaatgcac  ctgaacaca  tgcaccatc  ctgccctcc  2100
ggggtctac  ttgtagttg  cggggaagg  cagatgtca  ccaggtaca  aaatgaaga  2160
ggtagtgat  agggacaag  ctggcctga  ggcagaggg  gaggaaagg  gcagccgtg  2220
aaagccccc  ggagctgaa  gggcggtgc  gtaggggag  tgaggtcag  gaagtatcc  2280
gggcctggc  acataggcc  tgagccctg  caggacctc  actttctcg  ggaggaaga  2340
aggagcaat  atggctggc  tctctgtct  gcgtgggct  gtaccagag  cgcaggggt  2400
ttggttagg  ggccgctgt  gcaaccagg  tgggagccc  ggaaggggc  agcagggtc  2460
gagtctaga  aggatttgg  gacagcaga  gggaattgc  cacagaatg  gtttgcctg  2520
gggctcttt  ttcatcctc  aggtgtcct  cgacagatg  accatttgt  acccccacc  2580
tctgtaccc  agccctggg  caggtgccc  attattcac  cacgctcct  acccctcat  2640
gccaggagc  agcatggtt  tcattaagc  gtcacctgt  gccctatgt  cgagttccg  2700
ctgtgctct  gccctcagg  tcaaggtag  aggggcctg  cctatgctg  ccacactga  2760
catcctggc  ggcccctcc  ttcttacct  cagggcttg  actagggac  gtctgttcc  2820
caggctcag  gatgctgtt  tcctggagg  gcaagtgct  ctcaaggaa  tgtgggagg  2880
gggaacagt  tcttacagg  gaagcaggg  aggcactgc  gggacagac  cctcctcat  2940
ccatggagg  ctcacatgg  gaacagaag  acggaggcc  cacttgggg  gtaggagaa  3000
gtgacaagg  cctctccgg  cccagcacc  ggccagagg  tgtgagtgc  tgtgcttgg  3060
gctgagggg  ctccagagg  tccttggcc  ctgcactct  ggggagccg  tccagggtc  3120
tttccctga  ggtccatcc  ccgccgcga  gcaggtgac  agccaagat  aggctccgg  3180
tgtaatccg  aaggccatg  acaaacaca  cctggagga  gaggagccg  aggactatg  3240
gctgctgca  attctctca  atgaccgga  taagtcaga  gaccagagg  cgatggcag  3300
gggggcagg  ccacaccac  ccccagccc  aggttggaa  cctttggcc  cagaaaatt  3360
accagcaga  tgtgggtag  cactgtgga  agggcagcc  tggctgccc  cattgtctg  3420
ttgctgtcc  cagcaacca  tggacctcc  cagtgtgtg  ccttcccta  gcgtgaaca  3480
gcagttcaa  gctcacatc  gtgaggagc  aagagaaaa  gcatttttc  ctgggacag  3540
ttagccacg  ggcccactg  aagggacgc  ttctggcta  gacaagaaa  catgtgctc  3600
acaaagaat  gtgacagct  tggaccaaa  tgtcaagtg  taaaatcca  gagtgtgtg  3660
ttctaaaag  agaacaggc  actaggagg  caactcagt  ttctagaaa  tgggaaagt  3720
tcaagaacc  gtgcaggct  agagtgggg  atcctgggc  tggagacgc  gggcaagct  3780
cttaagccc  ctgtgcttg  cttctcatc  cccaaatgg  aatgaaagt  gccagtgtg  3840
tcatcatat  tgtaaaaat  tatatgtat  tatatatgt  tatatatat  catgtatat  3900
tgtgtgtat  tatatgcat  tatatgtgt  tgtatatat  tgcatgtat  tataaagca  3960
ctatgtgca  cataaaagt  aactataaa  actatcatc  ctgttttct  tccagtgag  4020
tgaacacca  ctcccacca  tagcccaga  agtaagcaa  gactcctgt  atccctaga  4080
gttacagtc  aaatcctct  gcagcttct  gcaccattt  ggttaggtg  gcagggtag  4140
cgggacccc  atcttacag  aaaggaaga  tgaggccta  agaggttaa  gatgacgaa  4200
agccacacg  tgtcggcag  agcacaaat  gagcccagc  ctggtttat  gcaggctgt  4260
ggccagagg  gatggtggg  aatggagcc  aaaggaagt  cttgccggg  gccagggtt  4320
aaggagtac  ggcctccct  gaacgggcg  cagagccct  gggcaggcc  gtcctttcc  4380
ggtccttgg  tcccttgtc  tgagtaggg  aggattctg  gaggtgacc  ggattctag  4440
aagcctgtt  caggtgggc  gccagcact  cagtatggg  aggacgggg  gaccctctg  4500
cagctcagg  caagccggg  ggttctgga  tcagtccct  tttaaacaa  agtcatcag  4560
ttttgtgag  acctcagca  agtctgtcc  caggcagga  tcattgaga  gggtccttg  4620
agttctgga  ctgtattgg  ggggatctg  ggtctgtgg  tcaagacag  ccttgtatg  4680
gctctcaag  ggtaggggt  tcctgcagg  cccccagga  catccctga  cacccctct  4740
cccctcccc  ccagagctg  agatccctg  aaacgccaa  gtcttctat  ccatgaact  4800
tactgccaa  tatgacttt  tcctgaaga  gcggacctt  accaaggga  tgaaggtca  4860
gcacggagc  agctccacc  tccctcgca  gaagcagaa  ggactcaag  ttgccaagg  4920
catcttctg  gggcatcct  ccagggtct  gctggctgg  agccaagca  ttatggacc  4980
gagtggccc  ggccagctg  gcgccttcc  cccacctgc  agcccaggg  accccagac  5040
ccagtttca  cctgaacct  tcccgctgc  gggattgac  cctgccatt  gtcaggctg  5100
cctggcctc  cgtggacca  tcgctgcct  aggtgcctt  tgctctctg  aaccagagg  5160
ctagctgac  tttgccaag  agcagtgcc  acgggcatg  catggtgcc  tgcctgccc  5220
cgggcgcca  ctctgtaca  ttccctgac  ccttcccag  tgtgggtca  tgccacctg  5280
gcccatggg  accccagag  acccactgt  accactgca  ttctctcat  cccacaggc  5340
ctggcctgt  accttcgca  gggtcccgg  ccctcccac  actctagcc  ttctcaggc  5400
gcaccaaag  ttccatcat  agggccaac  gagagtgag  gagtctcac  caccgctta  5460
cccagccct  ccctgggag  agagagaga  accctcttc  tggaccaga  tctgcaccc  5520
gtgagtgag  acagtccca  ctgagtccc  tcgatgttg  atctcatgc  actgcaagt  5580
ccattcacc  ctgcgtcct  ggctttacg  gaccatgca  gacgggggt  agtgaggaa  5640
gaggatttg  ggtgggggt  gggtgattg  atatttgta  aaaaagcaa  aagaaaaaa  5700
aaatgtttg  ttactgatt  gggaggggc  atatttatt  gttgtaaat  gcaaatgct  5760
gacttgaat  ttatattaa  atcctgttt  tactat  5796



<210> 2829
<211> 914
<212> PRT
<213> Homo sapiens
<308> Q12967
<400> 2829

Met Val Gln Arg Met Trp Ala Glu Ala Ala Gly Pro Ala Gly Gly Ala 
  1               5                  10                  15
Glu Pro Leu Phe Pro Gly Ser Arg Arg Ser Arg Ser Val Trp Asp Ala 
             20                  25                  30
Val Arg Leu Glu Val Gly Val Pro Asp Ser Cys Pro Val Val Leu His 
         35                  40                  45
Ser Phe Thr Gln Leu Asp Pro Asp Leu Pro Arg Pro Glu Ser Ser Thr 
     50                  55                  60
Gln Glu Ile Gly Glu Glu Leu Ile Asn Gly Val Ile Tyr Ser Ile Ser 
 65                  70                  75                  80
Leu Arg Lys Val Gln Leu His His Gly Gly Asn Lys Gly Gln Arg Trp 
                 85                  90                  95
Leu Gly Tyr Glu Asn Glu Ser Ala Leu Asn Leu Tyr Glu Thr Cys Lys 
             100                105                110
Val Arg Thr Val Lys Ala Gly Thr Leu Glu Lys Leu Val Glu His Leu 
         115                120                125
Val Pro Ala Phe Gln Gly Ser Asp Leu Ser Tyr Val Thr Ile Phe Leu 
     130                135                140
Cys Thr Tyr Arg Ala Phe Thr Thr Thr Gln Gln Val Leu Asp Leu Leu 
 145                150                155                160
Phe Lys Arg Tyr Gly Arg Cys Asp Ala Leu Thr Ala Ser Ser Arg Tyr 
                 165                170                175
Gly Cys Ile Leu Pro Tyr Ser Asp Glu Asp Gly Gly Pro Gln Asp Gln 
             180                185                190
Leu Lys Asn Ala Ile Ser Ser Ile Leu Gly Thr Trp Leu Asp Gln Tyr 
         195                200                205
Ser Glu Asp Phe Cys Gln Pro Pro Asp Phe Pro Cys Leu Lys Gln Leu 
     210                215                220
Val Ala Tyr Val Gln Leu Asn Met Pro Gly Ser Asp Leu Glu Arg Arg 
 225                230                235                240
Ala His Leu Leu Leu Ala Gln Leu Glu His Ser Glu Pro Ile Glu Ala 
                 245                250                255
Glu Pro Glu Ala Leu Ser Pro Val Pro Ala Leu Lys Pro Thr Pro Glu 
             260                265                270
Leu Glu Leu Ala Leu Thr Pro Ala Arg Ala Pro Ser Pro Val Pro Ala 
         275                280                285
Pro Ala Pro Glu Pro Glu Pro Ala Pro Thr Pro Ala Pro Gly Ser Glu 
     290                295                300
Leu Glu Val Ala Pro Ala Pro Ala Pro Glu Leu Gln Gln Ala Pro Glu 
 305                310                315                320
Pro Ala Val Gly Leu Glu Ser Ala Pro Ala Pro Ala Leu Glu Leu Glu 
                 325                330                335
Pro Ala Pro Glu Gln Asp Pro Ala Pro Ser Gln Thr Leu Glu Leu Glu 
             340                345                350
Pro Ala Pro Ala Pro Val Pro Ser Leu Gln Pro Ser Trp Pro Ser Pro 
         355                360                365
Val Val Ala Glu Asn Gly Leu Ser Glu Glu Lys Pro His Leu Leu Val 
     370                375                380
Phe Pro Pro Asp Leu Val Ala Glu Gln Phe Thr Leu Met Asp Ala Glu 
 385                390                395                400
Leu Phe Lys Lys Val Val Pro Tyr His Cys Leu Gly Ser Ile Trp Ser 
                 405                410                415
Gln Arg Asp Lys Lys Gly Lys Glu His Leu Ala Pro Thr Ile Arg Ala 
             420                425                430
Thr Val Thr Gln Phe Asn Ser Val Ala Asn Cys Val Ile Thr Thr Cys 
         435                440                445
Leu Gly Asn Arg Ser Thr Lys Ala Pro Asp Arg Ala Arg Val Val Glu 
     450                455                460
His Trp Ile Glu Val Ala Arg Glu Cys Arg Ile Leu Lys Asn Phe Ser 
 465                470                475                480
Ser Leu Tyr Ala Ile Leu Ser Ala Leu Gln Ser Asn Ser Ile His Arg 
                 485                490                495
Leu Lys Lys Thr Trp Glu Asp Val Ser Arg Asp Ser Phe Arg Ile Phe 
             500                505                510
Gln Lys Leu Ser Glu Ile Phe Ser Asp Glu Asn Asn Tyr Ser Leu Ser 
         515                520                525
Arg Glu Leu Leu Ile Lys Glu Gly Thr Ser Lys Phe Ala Thr Leu Glu 
     530                535                540
Met Asn Pro Lys Arg Ala Gln Lys Arg Pro Lys Glu Thr Gly Ile Ile 
 545                550                555                560
Gln Gly Thr Val Pro Tyr Leu Gly Thr Phe Leu Thr Asp Leu Val Met 
                 565                570                575
Leu Asp Thr Ala Met Lys Asp Tyr Leu Tyr Gly Arg Leu Ile Asn Phe 
             580                585                590
Glu Lys Arg Arg Lys Glu Phe Glu Val Ile Ala Gln Ile Lys Leu Leu 
         595                600                605
Gln Ser Ala Cys Asn Asn Tyr Ser Ile Ala Pro Asp Glu Gln Phe Gly 
     610                615                620
Ala Trp Phe Arg Ala Val Glu Arg Leu Ser Glu Thr Glu Ser Tyr Asn 
 625                630                635                640
Leu Ser Cys Glu Leu Glu Pro Pro Ser Glu Ser Ala Ser Asn Thr Leu 
                 645                650                655
Arg Thr Lys Lys Asn Thr Ala Ile Val Lys Arg Trp Ser Asp Arg Gln 
             660                665                670
Ala Pro Ser Thr Glu Leu Ser Thr Ser Gly Ser Ser His Ser Lys Ser 
         675                680                685
Cys Asp Gln Leu Arg Cys Gly Pro Tyr Leu Ser Ser Gly Asp Ile Ala 
     690                695                700
Asp Ala Leu Ser Val His Ser Ala Gly Ser Ser Ser Ser Asp Val Glu 
 705                710                715                720
Glu Ile Asn Ile Ser Phe Val Pro Glu Ser Pro Asp Gly Gln Glu Lys 
                 725                730                735
Lys Phe Trp Glu Ser Ala Ser Gln Ser Ser Pro Glu Thr Ser Gly Ile 
             740                745                750
Ser Ser Ala Ser Ser Ser Thr Ser Ser Ser Ser Ala Ser Thr Thr Pro 
         755                760                765
Val Ala Ala Thr Arg Thr His Lys Arg Ser Val Ser Gly Leu Cys Asn 
     770                775                780
Ser Ser Ser Ala Leu Pro Leu Tyr Asn Gln Gln Val Gly Asp Cys Cys 
 785                790                795                800
Ile Ile Arg Val Ser Leu Asp Val Asp Asn Gly Asn Met Tyr Lys Ser 
                 805                810                815
Ile Leu Val Thr Ser Gln Asp Lys Ala Pro Ala Val Ile Arg Lys Ala 
             820                825                830
Met Asp Lys His Asn Leu Glu Glu Glu Glu Pro Glu Asp Tyr Glu Leu 
         835                840                845
Leu Gln Ile Leu Ser Asp Asp Arg Lys Leu Lys Ile Pro Glu Asn Ala 
     850                855                860
Asn Val Phe Tyr Ala Met Asn Ser Thr Ala Asn Tyr Asp Phe Val Leu 
 865                870                875                880
Lys Lys Arg Thr Phe Thr Lys Gly Val Lys Val Lys His Gly Ala Ser 
                 885                890                895
Ser Thr Leu Pro Arg Met Lys Gln Lys Gly Leu Lys Ile Ala Lys Gly 
             900                905                910
Ile Phe 
         915



<210> 2830
<211> 4444
<212> DNA
<213> Rattus norvegicus
<308> L08228
<400> 2830

tcgcgcagt  cgcgctgct  tcctttccg  cttttccgc  cgggtgttc  agcagcgcc  60
aacacgctt  agcacctcg  acagcatcc  ccgcgctcg  ccggggctc  tagagaacc  120
gggggcgct  gaccgcgcg  gggcggccc  cgggtcgta  atcgcgagg  cgtcgcact  180
gcgcaaccc  gagccaggc  cgctgtgcc  ggagctcat  agcaccatg  acctgctga  240
attcgccct  cttttttcc  gctccttcg  ccgcgccgc  tgcgacccc  agatcgtca  300
catcggcgc  gtgctgagc  cgcgcaagc  tgaacagat  ttccgcgag  cagtaaacc  360
ggccaataa  cgacacggc  cttggaaga  acagctcaa  gccacttct  tcacccaca  420
gcccaacgc  atacagatg  ccctgtcag  gtgtgagga  ctcatctct  gccaggtct  480
cgctatcct  gttagccac  cgcctactc  caacgacca  ttcactccc  cccctgtct  540
ctacacagc  ggcttctac  gaatccctg  cctgggact  actacccga  tgtccatct  600
ctctgacaa  ccctctgtc  atcacacag  tcggaaaga  caggcccgc  gcaccaaat  660
taatacaag  tgcctgcag  cagttgcag  ggcggtgaa  attctatcc  tacaatgca  720
tgcccctga  caccaagag  gaaccggta  aaaactaac  tagaagcat  agagggcca  780
gagcagtgt  aatcatgac  gtgcggaag  agccatgtt  actcagagt  tccacctga  840
tttccttcg  acggtgccg  cctactccc  ccagtccag  gtctggttt  agatgatgc  900
agtctacaa  tggaaccac  tcatcctgc  ggtcagcga  gaccacgag  gacgggcag  960
gcagaagcg  ttggagacg  tgctggagg  acgggagtc  aagagtaaa  aaaggaact  1020
tgaaaacct  gaccaactg  cctatgaca  caagcgcgg  cccaaggca  agaaggtgc  1080
gcagtttga  ccaggaacc  agaatgtga  ggctctgct  atggaggcc  gggaactgg  1140
ggcccgggt  atcatcctt  ctgcaagcg  ggacgacgc  gccacagtg  accgcgcag  1200
cgcaatgct  aacatgacg  gctctgggt  cgtgtggct  gtcggggaa  gcgagatct  1260
tgggaacgc  ctgcgctac  ctcctgatg  catcatcgg  cttcagctc  tcaatggca  1320
gaatgagtc  gcccacatc  gtgacgccg  gggcgtggt  gcacaggca  ttcacgaac  1380
cctagagaa  gagaatatc  ctgacccac  gcggggttg  gtgggcaac  ccaacatct  1440
gaagacagg  ccattgttc  agagggtgc  gatgtcttc  aagtatgcg  acggagtga  1500
tggccgtgt  gaattcaat  aggatgggg  ccggaagtt  gccaactat  gtatcatga  1560
cctgcagaa  cgcaagctg  tgcaagtgg  catctacaa  ggtacccat  tcatcccaa  1620
tgacaggaa  atcatctgg  caggaggag  gacagagaa  cctcgagga  accagatgt  1680
caccagact  aagatagtg  caatccacc  agagccctt  gtgtacgtc  agcccacaa  1740
gagtgatgg  acatgcaaa  aggagttca  agtcaatgg  gacccagtg  agaaggtga  1800
ctgtacggg  cctaatgac  cgtccccag  cagcccacg  cacacagtg  cccagtgct  1860
ctatggctt  tgcatagac  tgctcatca  gctggcgcg  accatgaat  ttacctatg  1920
ggtgcacct  gtggcagat  gcaagtttg  cacacagga  cgggtaaac  acagcaaca  1980
aaaggagtg  aacggaatg  tgggcgagc  actcagtgg  caagcggac  tgattgtgg  2040
accactgac  atcaacaat  agcgtgcgc  gtacataga  ttctccaag  ccttcaagt  2100
ccagggcct  accattttg  tcaagaagg  gattcccag  agcacactg  actcattta  2160
gcagccttt  cagagcaca  tgtggttgc  agtaggact  tcagttcat  tggtggctg  2220
gatgctgta  ctgctggac  gcttcagtc  ctttggccg  ttcaaggtg  acagtgagg  2280
ggaggagga  gatgcactg  ccctgtcct  tgccatgtg  ttttcctgg  gcgtcctgc  2340
caactccgg  attggggaa  gtgcccccc  gagtttctc  gcacgtatc  taggcatgg  2400
gtgggctgg  ttcgccatg  tcatagtgg  ttcctacac  gccaacttg  cagctttcc  2460
ggtgctgga  cggcctgag  agcgcatca  gggcatcaa  gaccccagg  tcagaaacc  2520
ctcagacaa  ttcatctac  caactgtaa  gcagagctc  gtggacatc  acttccgga  2580
gcaggtgga  ttgagtacc  tgtaccggc  catggaaaa  cacaattac  agagcgcag  2640
tgaggccat  caggctgtg  gggacaaca  gctgcacgc  tttatctgg  actcggccg  2700
gctggagtt  gaggcttca  agaagtgcg  tctggtgac  acgggtgag  tgttcttcc  2760
ctcaggctt  ggcatcggc  tgcgcaagg  cagcccctg  aagcagaac  tttccctgt  2820
catactcaa  tcccatgag  atggcttca  ggaagatct  gataagaca  gggttcggt  2880
tcaggaatg  gactcccgc  gcaatgctc  tgcaaccct  acttttgag  acatggcag  2940
ggtcttcat  ctggtggct  gaggcatcg  agctgggat  ttcctcatt  tcattgaga  3000
cgcctacaa  cgacacaag  atgcccgta  gaagcagat  cagctggct  ttgcagccg  3060
gaacgtgtg  aggaagaac  tgcaggata  aaagagtgg  agagcagag  ccgacccta  3120
aaagaaagc  acatttagg  ctatcacct  caccctggc  tccagcttc  agagacgta  3180
gtcctccaa  gacacgagc  ccgggggtg  acgcggcgc  ttgcaaaac  aaaaagaca  3240
agtgctgcc  cgacgcgct  ttgagaggg  ggagggcca  ctgcagctg  gttcccgtc  3300
tagggagag  tgagacgcc  cgcccgccc  cctctgccc  tcccccgca  acagacgca  3360
gggacagcg  cctggccca  gcagagccc  ggagcacga  ggggtcggg  gaggagcac  3420
cccagcctc  cccaggccg  gcccgcctg  ccaccggtc  gccggctgg  cggtccacc  3480
tgtcccggc  ccgcgcgtg  ccccgacgt  ggagctaac  ggccgcctt  tctgtgtat  3540
tctatttta  agcagtacc  tcccactga  atcacgggc  cgctcaacc  ctcagatcc  3600
tcggtcagc  ccgtggtgt  aggcccccc  gaggcgccc  cctgcccag  tagcccggc  3660
aaggacact  atgagtcct  ctgctcggg  aggcctgag  gaagcccac  cgccccaga  3720
actgcccac  ctgggcctc  cgtccgcct  ctctgctgc  tggcgggca  cccctgcag  3780
accaaggtg  ggaccagag  ggctgagga  gggccagag  tgagccggc  gggcagggc  3840
acagggcgc  ccggcagag  cagggccct  aggtctctg  gcagtgggg  gaggggcct  3900
agtggcccc  gtcggagga  tctggagca  aaatggcag  cccatcctt  ctccagcca  3960
taccccaag  tacagtggg  gcctatggc  ccagcttgc  aggtcaccc  cgacccttc  4020
tccagcgcc  gctctctgc  acttgattt  cacctctct  ctgctgcac  accctccca  4080
gacatttcc  caccccatt  actgggttg  ctctgacct  tcccagggc  agccttcac  4140
gccctagtg  cagtgcttc  ggggtgctt  ctggctccc  gacatctag  gctccagac  4200
ccaagaggg  tgagccttc  cttctgtcc  cagccacaa  aggcttcct  agacgctgg  4260
tcgtgatga  tcccgcacc  tgggcacca  ggagcgcca  ctgcctccc  gtccggtgt  4320
actcacccc  ctaccttgt  catgaccag  tctcccagt  tcccagtgt  tgccccagg  4380
acaccgggc  cgcacagcc  cccctaatc  cggtattca  tggtgatgc  taaaggaat  4440
tcag  4444



<210> 2831
<211> 938
<212> PRT
<213> Rattus norvegicus
<308> AAB50928
<400> 2831

Met Ser Thr Met His Leu Leu Thr Phe Ala Leu Leu Phe Ser Cys Ser 
  1               5                  10                  15
Phe Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
             20                  25                  30
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
         35                  40                  45
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
     50                  55                  60
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
 65                  70                  75                  80
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                 85                  90                  95
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
             100                105                110
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
         115                120                125
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
     130                135                140
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Asn Trp 
 145                150                155                160
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                 165                170                175
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
             180                185                190
Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
         195                200                205
Met Glu Ala Arg Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
     210                215                220
Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
 225                230                235                240
Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                 245                250                255
Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Ile Gly Leu Gln Leu Ile 
             260                265                270
Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
         275                280                285
Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
     290                295                300
Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
 305                310                315                320
Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                 325                330                335
Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
             340                345                350
Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
         355                360                365
Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
     370                375                380
Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
 385                390                395                400
Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Met Ser 
                 405                410                415
Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
             420                425                430
Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
         435                440                445
His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
     450                455                460
Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
 465                470                475                480
Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                 485                490                495
Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
             500                505                510
Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
         515                520                525
Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
     530                535                540
Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser 
 545                550                555                560
Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met 
                 565                570                575
Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn 
             580                585                590
Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp 
         595                600                605
Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro 
     610                615                620
Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala 
 625                630                635                640
Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val 
                 645                650                655
Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu 
             660                665                670
Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser 
         675                680                685
Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg 
     690                695                700
His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala 
 705                710                715                720
Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu 
                 725                730                735
Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu 
             740                745                750
Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp 
         755                760                765
Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe 
     770                775                780
Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser 
 785                790                795                800
Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val 
                 805                810                815
Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe 
             820                825                830
Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met 
         835                840                845
Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Asp 
     850                855                860
Arg Lys Ser Gly Arg Ala Glu Pro Asp Pro Lys Lys Lys Ala Thr Phe 
 865                870                875                880
Arg Ala Ile Thr Ser Thr Leu Ala Ser Ser Phe Lys Arg Arg Arg Ser 
                 885                890                895
Ser Lys Asp Thr Ser Thr Gly Gly Gly Arg Gly Ala Leu Gln Asn Gln 
             900                905                910
Lys Asp Thr Val Leu Pro Arg Arg Ala Ile Glu Arg Glu Glu Gly Gln 
         915                920                925
Leu Gln Leu Cys Ser Arg His Arg Glu Ser 
     930                935



<210> 2832
<211> 5137
<212> DNA
<213> Homo sapiens
<308> NM_007327
<400> 2832

ggtaaggct  tggaaaagg  ggcgctggg  gcgcattgc  agggggctg  agagggaga  60
aggagcgga  gctgagggt  tgaaacggc  ggccccgaa  acacctcgc  gcgctccag  120
gattcctgg  gtccgacct  agccccagt  agtgcgggt  cagtttcca  gctctcgcg  180
aaggcctgg  tgagcacat  cggcagcca  ggtcgccct  cctattcct  ttagcccga  240
gaggggggt  ccaagttac  tggccacgc  gatggggcc  ctccctcat  tctgaacct  300
gtggggagg  gaaccttga  gggagcgcc  cccagagcc  tggcttagg  cctccccca  360
ccctctgga  ctccagtct  caagagtca  gagccgaaa  atcgctgac  gtgggtgac  420
actcttgcg  gcacacaca  atacaagcg  gcacgacgc  ttcggtcct  ttaaaaggc  480
cgcaagggt  cggctgcac  cggtgacac  gacccctct  acgtttcca  actgagctc  540
ctgcaggtc  ccgacagca  aggcccctg  cccaggacc  ctccaggca  gcgctcaca  600
gcacacgcg  gctccccgg  tcacgcgcg  tccgacaca  acgctcacg  gaacgcagg  660
gcacgctct  gcgcgggag  cgccccttc  cctccgtgt  gggaagcgg  ggcggcggg  720
ggggcagga  acgttggcc  cgctcgcgt  tctgcagct  ctgcagtcg  cgcagcgtc  780
ggaccggaa  cagcgccgt  cgcggagcc  ccgccgccg  cgccgggcc  tttccaagc  840
gggcgctcg  agctgtgcc  ggccccgct  cagcaccgc  gacagcgcc  gccgcgtgg  900
gctgagccg  gcccccgcg  acgcttcag  gccccttcc  tcggccgac  tcccgggac  960
gccgctccg  gggagacgt  gcgtccgca  cccgcgggg  cgggcgagc  caggacggc  1020
cggaagccc  gcgggggat  cgccgaggg  cccgcgttc  cgccgcgca  agccaggcc  1080
gcggcccga  cccatgagc  ccatgcgcc  gctgacgct  gccctgctg  tctcctgct  1140
cgtcgcccg  gccgcgtgc  accccaaga  cgtcaacat  ggcgcggtg  tgagcacgc  1200
gaagcacga  cagatgttc  gcgaggccg  gaaccaggc  aacaagcgg  acggctcct  1260
gaagattca  ctcaatgcc  cctccgtca  gcacaagcc  aacgccatc  agatggctc  1320
gtcggtgtg  gaggacctc  tctccagcc  ggtctacgc  atcctagtt  gccatccac  1380
tacccccaa  gaccacttc  ctcccaccc  tgtctccta  acagccggc  tctaccgca  1440
acccgtgct  gggctgacc  cccgcatgt  catctactc  gacaagagc  tccacctga  1500
cttcctgcg  accgtgccg  cctactccc  ccagtccag  gtgtggttt  agatgatgc  1560
tgtctacag  tggaaccac  tcatcctgc  ggtcagcga  gaccacgag  gccgggcgg  1620
tcagaaacg  ctggagacg  tgctggagg  gcgtgagtc  aaggcagag  aggtgctgc  1680
gtttgaccc  gggaccaag  acgtgacgg  cctgctgat  gaggcgaaa  agctggagg  1740
ccgggtcat  atcctttct  ccagcgagg  cgatgctgc  actgtatac  gcgcagccg  1800
gatgctgaa  atgacgggc  ccgggtacg  gtggctggt  ggcgagcgc  agatctcgg  1860
gaacgccct  cgctacgcc  cagacggca  cctcgggct  cagctcatc  acggcaaga  1920
cgagtcggc  cacatcagc  acgccgtgg  cgtggtggc  caggccgtg  acgagctcc  1980
cgagaagga  aacatcacc  acccgccgc  gggctgcgt  ggcaacacc  acatctgga  2040
gaccgggcc  ctcttcaag  gagtgctga  gtcttccaa  tatgcggat  gggtgactg  2100
tcgcgtgga  ttcaatgag  atggggacc  gaagttcgc  aactacagc  tcatgaacc  2160
gcagaaccg  aagctggtg  aagtgggca  ctacaatgg  acccacgtc  tccctaatg  2220
caggaagat  atctggcca  gcggagaga  agagaagcc  cgagggtac  agatgtcca  2280
cagactgaa  attgtgacg  tccaccagg  gcccttcgt  tacgtcaag  ccacgctga  2340
tgatgggac  tgcaaggag  agttcacag  caacggcga  ccagtcaag  aggtgatct  2400
caccgggcc  aacgacacg  cgccgggca  cccccgcca  acggtgcct  agtgttgct  2460
cggcttttg  atcgacctg  tcatcaagc  ggcacggac  atgaacttc  cctacgagg  2520
gcacctggt  gcagatggc  agttcggca  acaggagcg  gtgaacaac  gcaacaaga  2580
ggagtggaa  gggatgatg  gcgagctgc  cagcgggca  gcagacatg  tcgtggcgc  2640
gctaaccat  aacaacgag  gcgcgcagt  catcgagtt  tccaagccc  tcaagtacc  2700
gggcctgac  attctggtc  agaaggaga  tccccggag  acgctggac  cgttcatgc  2760
gccgttcca  agcacactg  ggctgctgg  ggggctgtc  gtgcacgtg  tggccgtga  2820
gctgtacct  ctggaccgc  tcagcccct  cggccggtt  aaggtgaac  gcgaggagg  2880
ggaggagga  gcactgacc  tgtcctcgg  catgtggtt  tcctggggc  tcctgctca  2940
ctccggcat  ggggaaggc  cccccagaa  cttctcagc  cgcatcctg  gcatggtgt  3000
ggccggctt  gccatgatc  tcgtggcct  ctacaccgc  aacctggcg  ccttcctgg  3060
gctggaccg  ccggaggag  gcatcacgg  catcaacga  cctcggctg  ggaacccct  3120
ggacaagtt  atctacgcc  cggtgaagc  gagctccgt  gatatctac  tccggcgcc  3180
ggtggagct  agcaccatg  accggcata  ggagaagca  aactacgag  gtgcggcgg  3240
ggccatcca  gccgtgaga  acaacaagc  gcatgcctt  atctgggac  cggcggtgc  3300
ggagttcga  gcctcgcag  agtgcgacc  ggtgacgac  ggagagctg  ttttccgct  3360
gggcttcgg  ataggcatg  gcaaagaca  cccctggaa  cagaacgtc  ccctgtcca  3420
cctcaagtc  cacgagaat  gcttcatgg  agacctgga  aagacgtgg  ttcggtatc  3480
ggaatgtga  tcgcgcagc  acgcccctg  gacccttac  tttgagaac  tggccgggg  3540
cttcatgct  gtagctggg  gcatcgtgg  cgggatctt  ctgattttc  tcgagattg  3600
ctacaagcg  cacaaggat  ctcgccgga  gcagatgca  ctggccttt  ccgccgtta  3660
cgtgtggcg  aagaacctg  aggatagaa  gagtggtag  gcagagcct  accctaaaa  3720
gaaagccac  tttagggct  tcacctcca  cctggcttc  agcttcaag  ggcgtaggt  3780
ctccaaaga  acgagcacc  ggggtggac  cggcgcttt  caaaaccaa  aagacacag  3840
gctgccgcg  cgcgctatt  agagggagg  gggccagct  cagctgtgt  cccgtcata  3900
ggagagctg  gactccccg  ccgccctcc  ctgccccct  ccccgcaga  agacagaca  3960
acggatggg  cagcggccc  gcccacgca  agccccgga  caccacggg  tcgggggag  4020
agcaccccc  gcctccccc  ggctgcgcc  gcccgcccg  cggttggcc  gctggccgg  4080
ccaccccgt  ccggccccg  gcgtgcccc  agcgtgggg  taacgggcg  cttgtctgt  4140
tatttctat  ttgcagcag  accatccca  tgatatcac  ggcccgctc  acctctcag  4200
tccctcggt  agcaccgtg  tgtgaggcc  ccggaggcg  ccacctgcc  agttagccc  4260
gccaaggac  ctgatgggt  ctgctgctc  ggaaggcct  agggaagcc  acccgcccc  4320
gagactgcc  accctgggc  tcccgtccg  ccgcccgcc  accccgctg  ctggcgggc  4380
gcccctgct  gaccaaggt  cggaccgga  cggctgagg  cggggcaga  ctgagtcgg  4440
tgggcaggg  gcagggcgc  ccggcagag  cagggccct  gggtctctg  gcagtgggg  4500
gcgggggct  actggcccc  ggcggaggg  cttggagca  agacggcag  cccatcctt  4560
ccgcagcac  agcctgagc  acagtgggg  ccatggccc  agctggctg  gtcgcccct  4620
ctcgggcgc  tgcgctcct  tgcagcctg  gctccaccc  cccctcttc  tgcggcacc  4680
cccacccac  ccccgtctg  cccttgacc  cacacgccg  ggctggccc  gccctcccc  4740
acggccgtc  ctgacttcc  agctggcag  gcctcccgc  gcctcgggc  gcctcctcc  4800
gactcgaga  ggctgagcc  ctcctctcc  cgtccggcc  gcagcccag  acgggcctc  4860
ccgggggtc  ccggacgct  gctcgggac  gtcttcaac  ctgccctgc  ccttgggca  4920
gggagagcg  cacccgccc  cccccgccc  cgctccggg  gcgtgaccg  cccgccacc  4980
tgtacagaa  cagcactcc  agggcccga  cgcgtgcct  ccccgtgcg  cccgtgcgc  5040
gccgcgctc  gcccctccg  ccccagggt  caggcgcgc  ccgcccaac  cccacctcc  5100
ggtgtatgc  gtggtgatg  ctaaaggaa  gtcacgc  5137



<210> 2833
<211> 938
<212> PRT
<213> Homo sapiens
<308> Q05586
<400> 2833

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
  1               5                  10                  15
Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
             20                  25                  30
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
         35                  40                  45
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
     50                  55                  60
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
 65                  70                  75                  80
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                 85                  90                  95
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
             100                105                110
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
         115                120                125
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
     130                135                140
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
 145                150                155                160
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                 165                170                175
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
             180                185                190
Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
         195                200                205
Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
     210                215                220
Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
 225                230                235                240
Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                 245                250                255
Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
             260                265                270
Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
         275                280                285
Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
     290                295                300
Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
 305                310                315                320
Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                 325                330                335
Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
             340                345                350
Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
         355                360                365
Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
     370                375                380
Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
 385                390                395                400
Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                 405                410                415
Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
             420                425                430
Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
         435                440                445
His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
     450                455                460
Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
 465                470                475                480
Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                 485                490                495
Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
             500                505                510
Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
         515                520                525
Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
     530                535                540
Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser 
 545                550                555                560
Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met 
                 565                570                575
Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn 
             580                585                590
Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp 
         595                600                605
Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro 
     610                615                620
Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala 
 625                630                635                640
Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val 
                 645                650                655
Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu 
             660                665                670
Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser 
         675                680                685
Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg 
     690                695                700
His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala 
 705                710                715                720
Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu 
                 725                730                735
Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu 
             740                745                750
Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp 
         755                760                765
Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe 
     770                775                780
Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser 
 785                790                795                800
Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val 
                 805                810                815
Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe 
             820                825                830
Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met 
         835                840                845
Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Asp 
     850                855                860
Arg Lys Ser Gly Arg Ala Glu Pro Asp Pro Lys Lys Lys Ala Thr Phe 
 865                870                875                880
Arg Ala Ile Thr Ser Thr Leu Ala Ser Ser Phe Lys Arg Arg Arg Ser 
                 885                890                895
Ser Lys Asp Thr Ser Thr Gly Gly Gly Arg Gly Ala Leu Gln Asn Gln 
             900                905                910
Lys Asp Thr Val Leu Pro Arg Arg Ala Ile Glu Arg Glu Glu Gly Gln 
         915                920                925
Leu Gln Leu Cys Ser Arg His Arg Glu Ser 
     930                935



<210> 2834
<211> 1651
<212> DNA
<213> Rattus norvegicus
<308> L08490
<400> 2834

ctcccgggt  tggagcgat  cggtgccca  aggggcccc  agctggaca  gcccgtgat  60
aagaaaagt  ggggtctct  tgactatct  tgggcctgg  ccctcattc  gagcactct  120
tcgggaaga  gctatggac  gccctccca  gatgaactt  aggacaaca  cactgtctt  180
acgaggatt  tggaccgac  gctggatgg  tatgacaat  gtctgagac  aggcttggg  240
gagcgtgta  ctgaagtga  gacggacat  tttgtcacc  gtttcggac  cgtgtcaga  300
cacgatatg  aatatacaa  agatgtgtt  ttccgccaa  gctggaagg  tgaaagatt  360
aaattcaaa  gacccatga  agtgctccg  ctgaacaac  tgatggcca  taaaatctg  420
actccagat  catttttcc  caatggaaa  aagtctgtg  cccacaaca  gaccatgcc  480
aataaactc  tgcgtatca  agaggatgg  acactgctg  acaccatga  gttgactgt  540
agagccgaa  gccccatgc  cttagaaga  tttcccatg  atgcccatg  ctgcccact  600
aaatttggg  gctatgctt  tacaagagc  gaagttgtc  atgagtgga  aagggagcc  660
gcccgctca  tggttgtgg  agaagatgg  tcacgttta  accagtatg  ccttcttgg  720
caaacagtt  actctggaa  tgttcagtc  agtactgga  aatatgtgg  tatgacgac  780
cactttcac  tgaagagaa  aatcggcta  tttgttatt  aaacatatc  gccatgcat  840
atgacagtc  ttctctccc  agtctcctt  tggcttaac  gagagtcag  accagcaag  900
actgtcttt  gagtgacga  cgttctgac  atgacaacc  tgagtatca  tgccagaaa  960
tccctccca  aggtggctt  tgcaacggc  atggactgg  ttattgcag  gtgctatgc  1020
ttcgtgttc  cggctctga  tgagtttgc  acagtaaac  atttcacca  gagagggta  1080
gcgtgggat  gcaaaagcg  ggttccaga  aagccaaag  aagtgaagg  tcctctcat  1140
aagaaaaac  acacatatg  tcctacagc  accagctat  cccctaact  agccagggg  1200
gaccccggc  tggccacta  tgctaaaag  gcgaccata  aaccgaaag  agtcaagcc  1260
gagacaaaa  cgccagaac  caagaaaac  tttaacagc  tcagcaaaa  cgaccgact  1320
tcaagaata  cctttccgc  gctatttgg  atctttaac  tagtctatt  ggccacgta  1380
ttaaacaga  agcctcagc  aaaagcccc  acaccccat  aataggttc  tttagtcgt  1440
ttctgttgt  cagtcctct  cactgagaa  cgctttctg  tctcaacgc  gtgattcct  1500
tctgcctta  tgcctctgt  ttaaaagaa  tcgaaggtt  ccttatttc  atatttcat  1560
tcgaacaag  gacccctgt  tgacagttc  gagcagggc  gagtattca  ctcggggac  1620
ggattctga  aggaagcca  agagcaaaa  c  1651



<210> 2835
<211> 455
<212> PRT
<213> Rattus norvegicus
<308> AAC42029
<400> 2835

Met Lys Lys Ser Arg Gly Leu Ser Asp Tyr Leu Trp Ala Trp Thr Leu 
  1               5                  10                  15
Ile Leu Ser Thr Leu Ser Gly Arg Ser Tyr Gly Gln Pro Ser Gln Asp 
             20                  25                  30
Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg Leu 
         35                  40                  45
Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg Val 
     50                  55                  60
Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val Ser 
 65                  70                  75                  80
Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser Trp 
                 85                  90                  95
Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg Leu 
             100                105                110
Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe His 
         115                120                125
Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys Leu 
     130                135                140
Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu Thr 
 145                150                155                160
Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp Ala 
                 165                170                175
His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala Glu 
             180                185                190
Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val Ala 
         195                200                205
Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr Val 
     210                215                220
Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met Thr 
 225                230                235                240
Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr 
                 245                250                255
Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe Trp 
             260                265                270
Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr Thr 
         275                280                285
Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu Pro 
     290                295                300
Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys Tyr 
 305                310                315                320
Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr Phe 
                 325                330                335
Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu Lys 
             340                345                350
Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr Ala 
         355                360                365
Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro Gly 
     370                375                380
Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val Lys 
 385                390                395                400
Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val Ser 
                 405                410                415
Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly Ile 
             420                425                430
Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln Leu 
         435                440                445
Lys Ala Pro Thr Pro His Gln 
     450                455



<210> 2836
<211> 1843
<212> DNA
<213> Homo sapiens
<308> NM_000806
<400> 2836

gcacaattc  gaggtaaca  cgcctgcgt  ttctccatg  taacataga  aaacagttg  60
ctccaaagc  gcagattgg  tattgggaa  caaatttgg  tgtgaaatc  tcagcaaag  120
agcacgcag  gtccatgat  gctcagacc  agtgagtga  aggcagagc  aggacgccc  180
tctgctctg  cgcgcccgg  ctcggactc  cagactcgc  ctggctcca  tctctccac  240
attctctct  ccagacttt  ccccggtct  aagagatcc  gtgtccaga  ggggcctta  300
ctgctccag  ccgcgatga  gaaaagtcc  ggtctgtct  actgtcttt  ggcctggat  360
ctccttctg  gcacactga  tggaagaag  tatggacag  cgtcattac  agatgaact  420
aaagacaat  ccactgtct  caccaggat  ttggacaga  tcctagatg  ctatgacaa  480
cgcctgaga  caggattgg  agagcgtgt  accgaagtg  agactgata  cttcgtcac  540
agtttcgga  ccgtttcag  ccatgatat  gaatataca  tagatgtat  tttccgtca  600
agctggaag  atgaaaggt  aaaatttaa  ggacctatg  cagtcctcc  gttaaataa  660
ctaatggca  gtaaaatcc  gactccgga  acatttttc  acaatggaa  gaagtcagt  720
gcccacaac  tgaccatgc  caacaaact  ctgcggatc  cagaggatg  caccttgct  780
tacaccatg  ggctgacag  gagagctga  tgtccgatg  atttggagg  cttccctat  840
gatgcccat  cttgcccac  aaaatttgg  agttatgct  atacaagag  agaagttgt  900
tatgaatgg  ccagagagc  agcacgctc  gtggttgta  cagaagatg  atcacgtct  960
aaccagtat  accttcttg  acaaacagt  gactctgga  ttgtccagt  aagtacagg  1020
gaatatgtt  ttatgacca  tcatttcca  ttgaagaga  agattggct  ctttgttat  1080
caaacatac  tgccatgca  aatgacagt  attctctca  aagtctcct  ctggctcaa  1140
agagagtct  taccagcaa  aactgtctt  ggagtaaca  ctgtgctca  catgacaac  1200
ttgagcatc  gtgccagaa  ctccctccc  aaggtggct  atgcaacag  tatggattg  1260
tttattgcc  tgtgctatg  ctttgtgtt  tcagctctg  ttgagtttg  cacagtaaa  1320
tatttcact  agagaggtt  tgcatggga  ggcaaaagt  tggttccag  aaagccaaa  1380
aaagtaaag  atcctctta  taagaaaaa  aacacttac  ctccaacag  aaccagcta  1440
acccctaat  tggccaggg  cgacccggg  ttagccacc  ttgctaaaa  tgcaaccat  1500
gaacctaaa  aggtcaagc  cgaaacaaa  ccaccagaa  ccaagaaaa  ctttaacag  1560
gtcagcaaa  ttgaccgac  gtcaagaat  gccttcccg  tgctatttg  aatctttaa  1620
ttagtctac  gggctacgt  tttaaacag  gagcctcag  taaaagccc  cacaccaca  1680
caatagatc  tttactcac  ttctgttgt  cagttcctc  gcactggga  tttatttat  1740
ttctcaacg  agtaattcc  atctgcctt  attgcctct  tcttaaaga  tttgaaagt  1800
tccttattt  cataattca  ttaagacaa  agacccctg  ctg  1843



<210> 2837
<211> 456
<212> PRT
<213> Homo sapiens
<308> P14867
<400> 2837

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
  1               5                  10                  15
Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
             20                  25                  30
Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
         35                  40                  45
Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
     50                  55                  60
Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
 65                  70                  75                  80
Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                 85                  90                  95
Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
             100                105                110
Leu Asn Asn Leu Met Ala Ser Lys Ile Arg Thr Pro Asp Thr Phe Phe 
         115                120                125
His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
     130                135                140
Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
 145                150                155                160
Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                 165                170                175
Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
             180                185                190
Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
         195                200                205
Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
     210                215                220
Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
 225                230                235                240
Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                 245                250                255
Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
             260                265                270
Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
         275                280                285
Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
     290                295                300
Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
 305                310                315                320
Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                 325                330                335
Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
             340                345                350
Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
         355                360                365
Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
     370                375                380
Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
 385                390                395                400
Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                 405                410                415
Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
             420                425                430
Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
         435                440                445
Leu Lys Ala Pro Thr Pro His Gln 
     450                455



<210> 2838
<211> 2559
<212> DNA
<213> Rattus norvegicus
<308> L08595
<400> 2838

tggatcccc  aattgcttt  taaaaaata  cttggaaac  ttgtccttt  ctgaattac  60
acactgtcc  cctttaatt  cctcgaaaa  tccaatcac  cggctgaag  catgccttg  120
gttcaggcg  agtatgggt  ctcgcctca  ggagccagc  ccgcttctc  gagctacag  180
taccactct  cgggagaat  cagctccga  ttcttaact  cagagtttg  caagtttag  240
atggacctc  ccaacactg  aattactgc  accacttct  tccccagct  cagtacctt  300
atggacaac  acagcacag  ctacgacgt  aagccacct  gcttgtacc  aatgcccct  360
tccggacag  agtcctcca  taaggtaga  gacattcag  tgcacaact  ccagcaaca  420
agccacctg  cccctcagt  cgaggagat  atgccacac  gcgggtcgg  ttactacaa  480
ccctcttcg  ccccgacac  cagcacccc  ggcttccag  tgcagcata  cccgatgtg  540
gacgatccg  gctcccttc  caacttcca  cagaactac  tggccacta  gcatatgat  600
gagcagagg  agacacctg  ctcccgcct  tcactcttc  cctttaagc  gtccgcccc  660
ggcactcct  tgtctagct  ccagatgcg  tttgacggg  ctctgcacg  ccccatgaa  720
ccggagccc  cgggcagcc  ccacgtagt  gatgggcag  ccttcgccg  gcccaatcc  780
attcgcaag  cggcatcca  gggcttccc  ggcctgcag  tcggccacg  gtcgcagtt  840
cttgacacg  aggtgcccc  gtcgccgtc  cggggctct  cctccaatg  gggtctgtg  900
gctgtttgc  gtgacaacg  ggcctgtca  cattacggt  ttcgcactt  tgagggctg  960
aaaggtttc  ttaagcgca  ggtgcaaaa  aacgcgaaa  atgtgtgtt  agcaaataa  1020
aattgccca  tggataagc  ccgccgaaa  cgttgtcag  actgtcggt  tcagaagtg  1080
ctggctgtt  ggatggtta  agaagtggt  cgcacggac  gtttaaaag  ccggagagg  1140
cgtctaccc  caaaaccga  gagcccaca  gatccctct  ccccctcac  tccgggatc  1200
gatcagtgc  ctcgtcaga  ccacgtcga  tccaatccg  caatgacca  cctggacta  1260
tccaggttc  aggcaaacc  tgactatca  atgagtgga  atgatactc  acatatcca  1320
cagttctac  atctcctga  tggctctat  gagatcatc  gagggtggg  agagaagat  1380
cctggcttt  ctgacctgc  caaagccag  caggacctg  tttttgaat  agctttctt  1440
gaattattt  ttctacgct  agcatacag  tccaaccca  tggagggta  actcatctt  1500
tgcaatggg  tggtcctgc  caggttgca  tgcgtgcgt  gctttgggg  atggattga  1560
tccattgtt  aattctcct  caacttgca  aatatgaac  tcgacattt  tgccttctc  1620
tgcattgct  ccctggcta  ggtcacaga  agacacggg  tcaaggaac  caagagagt  1680
gaagagcta  aaaacaaaa  tgtaaattg  cttaaagac  atgtgactt  caataatgg  1740
ggattgaac  gacccaact  cctgtccaa  ctgttgggg  agctcccag  acttcgcac  1800
ctttgcaca  aggggctcc  gcgcatttt  tacctgaaa  tggaagact  ggtaccacc  1860
ccagcaata  ttgacaaac  tttcctgga  accttacct  tctaagact  tctcccatg  1920
acgtcaaag  actggaaag  aaaaaaaaa  ccagagggg  ctggtcaag  tgggtagag  1980
gctggctga  gtgtccggt  catgtctcc  ttctgtaga  ccctagccc  cacccctaa  2040
gtaaacaaa  aaacaagca  acaaacaaa  acaaattaa  aactgttgc  atttcctaa  2100
ctgcaggca  aacgtgaaa  ggcattttg  ctccggggc  tcctggatt  agaaaacgg  2160
caacataca  agtacagtg  tataaactt  tttattatc  gttcaaaat  agtttattg  2220
tcagaagga  gattgcaaa  gtatgatgg  aaatgtttg  ccatgcttg  ttgttgcag  2280
taagacaaa  gtaaggcaa  tgtaacaca  acacacaca  acacacaca  acacacaca  2340
acctcttaa  gggaccctc  tattttgcc  tttaacaag  cttcaaagt  ttctgctgt  2400
aagaaagct  taatatata  taaaactaa  tgttgcgtg  gtggcatga  ttgaaggca  2460
aggcttgta  attttatcc  atgcagttt  gctttttaa  ttattttgt  cctatttat  2520
aataaatat  acaaattct  aaaagtaag  gtgtttgca  2559



<210> 2839
<211> 598
<212> PRT
<213> Rattus norvegicus
<308> Q07917
<400> 2839

Met Pro Cys Val Gln Ala Gln Tyr Gly Ser Ser Pro Gln Gly Ala Ser 
  1               5                  10                  15
Pro Ala Ser Gln Ser Tyr Ser Tyr His Ser Ser Gly Glu Tyr Ser Ser 
             20                  25                  30
Asp Phe Leu Thr Pro Glu Phe Val Lys Phe Ser Met Asp Leu Thr Asn 
         35                  40                  45
Thr Glu Ile Thr Ala Thr Thr Ser Leu Pro Ser Phe Ser Thr Phe Met 
     50                  55                  60
Asp Asn Tyr Ser Thr Gly Tyr Asp Val Lys Pro Pro Cys Leu Tyr Gln 
 65                  70                  75                  80
Met Pro Leu Ser Gly Gln Gln Ser Ser Ile Lys Val Glu Asp Ile Gln 
                 85                  90                  95
Met His Asn Tyr Gln Gln His Ser His Leu Pro Pro Gln Ser Glu Glu 
             100                105                110
Met Met Pro His Ser Gly Ser Val Tyr Tyr Lys Pro Ser Ser Pro Pro 
         115                120                125
Thr Pro Ser Thr Pro Gly Phe Gln Val Gln His Ser Pro Met Trp Asp 
     130                135                140
Asp Pro Gly Ser Leu His Asn Phe His Gln Asn Tyr Val Ala Thr Thr 
 145                150                155                160
His Met Ile Glu Gln Arg Lys Thr Pro Val Ser Arg Leu Ser Leu Phe 
                 165                170                175
Ser Phe Lys Gln Ser Arg Pro Gly Thr Pro Val Ser Ser Cys Gln Met 
             180                185                190
Arg Phe Asp Gly Pro Leu His Val Pro Met Asn Pro Glu Pro Ala Gly 
         195                200                205
Ser His His Val Val Asp Gly Gln Thr Phe Ala Val Pro Asn Pro Ile 
     210                215                220
Arg Lys Pro Ala Ser Met Gly Phe Pro Gly Leu Gln Ile Gly His Ala 
 225                230                235                240
Ser Gln Leu Leu Asp Thr Gln Val Pro Ser Pro Pro Ser Arg Gly Ser 
                 245                250                255
Pro Ser Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala Cys 
             260                265                270
Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys 
         275                280                285
Arg Thr Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn 
     290                295                300
Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe 
 305                310                315                320
Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp 
                 325                330                335
Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro 
             340                345                350
Gln Asp Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu 
         355                360                365
Val Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr 
     370                375                380
Ser Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr 
 385                390                395                400
Gln His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile 
                 405                410                415
Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys 
             420                425                430
Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val 
         435                440                445
Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe 
     450                455                460
Cys Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly 
 465                470                475                480
Glu Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met 
                 485                490                495
Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val 
             500                505                510
Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln 
         515                520                525
Asn Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly 
     530                535                540
Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro 
 545                550                555                560
Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                 565                570                575
Lys Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Asp Lys Leu Phe 
             580                585                590
Leu Asp Thr Leu Pro Phe 
         595



<210> 2840
<211> 3427
<212> DNA
<213> Homo sapiens
<308> X75918
<400> 2840

gctcgcgca  ggctccgcg  tcccttttg  ctgtccagc  ggccgcctg  ccctgctcc  60
tccctccgt  agtgtccgg  ttcccttcg  ccagctctc  cacccctac  cgaccccgg  120
gcccgggct  ccagaggga  ctgcacttc  gcagagttg  atgaatgaa  agagacgcg  180
agaactcct  aggaggaga  tggacaggc  ggactcccc  ttgcttttc  aaaaatctt  240
gaaactttg  ccttcattg  attacgaca  tgtccacct  taatttcct  gaaaacgcc  300
gtaactcgg  tgaagccat  ccttgtgtt  aggcgcagt  tgggtcctc  cctcaagga  360
ccagccccg  ttctcagag  tacagttac  actcttcgg  agaatacag  tccgatttc  420
taactccag  gtttgtcaa  tttagcatg  acctcacca  cactgaaat  actgccacc  480
cttctctcc  cagcttcag  acctttatg  acaactaca  cacaggcta  gacgtcaag  540
caccttgct  gtaccaaat  cccctgtcc  gacagcagt  ctccattaa  gtagaagac  600
ttcagatgc  caactacca  caacacagc  acctgcccc  ccagtctga  gagatgatg  660
cgcactccg  gtcggttta  tacaagccc  cctcgcccc  gacgcccac  accccgggc  720
tccaggtgc  gcacagccc  atgtgggac  acccgggat  tctccacaa  ttccaccag  780
actacgtgg  cactacgca  atgatcgag  agaggaaaa  gccagtctc  cgcctctcc  840
tcttctcct  taagcaatc  ccccctggc  ccccggtgt  tagttgcca  atgcgcttc  900
acgggcccc  gcacgtccc  atgaacccg  agcccgccg  cagccacca  gtggtggac  960
ggcagacct  cgctgtgcc  aaccccatt  gcaagcccg  gtccatggg  ttcccgggc  1020
tgcagatcg  ccacgcgtc  cagctgctc  acacgcagg  gccctcacc  ccgtcgcgg  1080
gctccccct  caacgaggg  ctgtgcgct  tgtgtgggg  caacgcggc  tgccaacac  1140
acggcgtgc  cacctgtga  ggctgcaaa  gcttcttta  gcgcacagt  caaaaaaat  1200
caaaatacg  gtgtttagc  aataaaaac  gcccagtgg  caagcgtcg  cggaatcgc  1260
gtcagtact  ccgatttca  aagtgcctg  ctgttggga  ggtcaaaga  gtggttcgc  1320
cagacagtt  aaaaggccg  agaggtcgt  tgccctcga  accgaagag  ccacaggag  1380
cctctcccc  ttcgccccc  gtgagtctg  tcagtgccc  cgtcagggc  catgtcgac  1440
ccaacccgg  tatgaccag  ctggactat  ccaggttcc  ggcgaaccc  gactatcaa  1500
tgagtggag  tgacaccca  catatccag  aattctatg  tctcctgac  ggctccatg  1560
agatcatcc  gggctgggc  gagaagatc  ctggcttcg  agacctgcc  aaagccgac  1620
aagacctgc  ttttgaatc  gctttctta  aactgtttg  ccttcgatt  gcatacagg  1680
ccaacccag  ggagggtaa  ctcatcttt  gcaatgggg  ggtcttgca  aggttgcaa  1740
gcgttcgtg  ctttgggga  tggattgat  ccattgttg  attctcctc  aacttgcag  1800
atatgaaca  cgacatttc  gccttctcc  gcattgctg  cctggctat  gtcacagag  1860
gacacgggc  caaggaacc  aagagagtg  aagaactgc  aaacaagat  gtaaattgt  1920
tcaaagacc  cgtgacttt  aacaatggg  ggttgaacc  ccccaatta  ttgtccaaa  1980
tgttgggga  gctcccaga  cttcgtacc  tttgcacac  ggggctaca  cgcattttc  2040
acctgaaat  ggaagactt  gtgccaccg  cagcaataa  tgacaaact  ttcctggac  2100
ctttacctt  ctaagacct  ctcccaagc  cttcaaagg  actggaatg  taatggaaa  2160
tgtcaagag  gggcaagtc  catgggcag  gatagccgt  tgagcagtc  cagctcaag  2220
tgcccccca  ttctgtaac  ctcctagcc  ccttgatcc  taaagaaaa  aaacaaaca  2280
acaaaaact  ttgctattt  ctaacctgc  ggcagaacc  gaaagggca  tttggctcc  2340
gggcatcct  gatttagaa  atggactac  cacaataca  tggtataaa  tttttattc  2400
cagtttaaa  atcagtttg  tgttcagaa  aaagattgc  ataaggtat  atgggaaat  2460
tttggccat  cttggttgt  gcagttcag  caaatgtaa  acacacaca  atacacaca  2520
acacacaca  agagacaca  cttaagggg  cccacaagt  ttgcccttt  acaagactt  2580
aaagttttc  gctgtaaag  aagctgtaa  atatagtaa  actaaatgt  gcgtgggtg  2640
catgagttg  agaaggcaa  ggcttgtaa  tttacccaa  gcagtttgg  tttttaaat  2700
attttgtgc  tatttatga  taaatatta  aaattctaa  agataagtg  gtttgcaaa  2760
aaaaagaaa  taaatacat  aaaaaggga  aagcatgtt  attctaggt  gaaaatgtt  2820
taggcactt  ctacttcag  aatgtctat  ttatataaa  agtatttca  acactatgt  2880
gtctgttag  ttttataaa  attggtagt  atctgagct  aaacatttt  tcaattgta  2940
aataggtgg  cacaagtat  acacatcag  aaatcctga  aaaagggac  catagtgtt  3000
gtaacaccg  ccaacattc  ttgtttgta  gtgttgtat  taccgttga  gttgataaa  3060
agaaagttt  tatcttgat  attttgttg  ctaaagcta  acaaaactt  catgcagca  3120
cttttgact  tttccagag  gcttataat  tacataact  cctggaaat  actgagcac  3180
ttgaatttt  tttatgtct  aaattgtca  ttaatttat  attttgttt  agtaagaat  3240
ttaatattg  catattctg  agtattttt  tttgtatat  tctagtatg  cacatgata  3300
gagtcactg  ctttttttc  atggtgtat  acagttaga  atgctgatt  tttttctga  3360
aaattcttt  tttgagaaa  acaatttta  tgtttacaa  aataaacca  gtaaatgaa  3420
aaaaaaa  3427



<210> 2841
<211> 598
<212> PRT
<213> Homo sapiens
<308> P43354
<400> 2841

Met Pro Cys Val Gln Ala Gln Tyr Gly Ser Ser Pro Gln Gly Ala Ser 
  1               5                  10                  15
Pro Ala Ser Gln Ser Tyr Ser Tyr His Ser Ser Gly Glu Tyr Ser Ser 
             20                  25                  30
Asp Phe Leu Thr Pro Glu Phe Val Lys Phe Ser Met Asp Leu Thr Asn 
         35                  40                  45
Thr Glu Ile Thr Ala Thr Thr Ser Leu Pro Ser Phe Ser Thr Phe Met 
     50                  55                  60
Asp Asn Tyr Ser Thr Gly Tyr Asp Val Lys Pro Pro Cys Leu Tyr Gln 
 65                  70                  75                  80
Met Pro Leu Ser Gly Gln Gln Ser Ser Ile Lys Val Glu Asp Ile Gln 
                 85                  90                  95
Met His Asn Tyr Gln Gln His Ser His Leu Pro Pro Gln Ser Glu Glu 
             100                105                110
Met Met Pro His Ser Gly Ser Val Tyr Tyr Lys Pro Ser Ser Pro Pro 
         115                120                125
Thr Pro Thr Thr Pro Gly Phe Gln Val Gln His Ser Pro Met Trp Asp 
     130                135                140
Asp Pro Gly Ser Leu His Asn Phe His Gln Asn Tyr Val Ala Thr Thr 
 145                150                155                160
His Met Ile Glu Gln Arg Lys Thr Pro Val Ser Arg Leu Ser Leu Phe 
                 165                170                175
Ser Phe Lys Gln Ser Pro Pro Gly Thr Pro Val Ser Ser Cys Gln Met 
             180                185                190
Arg Phe Asp Gly Pro Leu His Val Pro Met Asn Pro Glu Pro Ala Gly 
         195                200                205
Ser His His Val Val Asp Gly Gln Thr Phe Ala Val Pro Asn Pro Ile 
     210                215                220
Arg Lys Pro Ala Ser Met Gly Phe Pro Gly Leu Gln Ile Gly His Ala 
 225                230                235                240
Ser Gln Leu Leu Asp Thr Gln Val Pro Ser Pro Pro Ser Arg Gly Ser 
                 245                250                255
Pro Ser Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala Cys 
             260                265                270
Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys 
         275                280                285
Arg Thr Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn 
     290                295                300
Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe 
 305                310                315                320
Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp 
                 325                330                335
Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro 
             340                345                350
Gln Glu Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu 
         355                360                365
Val Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr 
     370                375                380
Ser Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr 
 385                390                395                400
Gln His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile 
                 405                410                415
Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys 
             420                425                430
Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val 
         435                440                445
Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe 
     450                455                460
Cys Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly 
 465                470                475                480
Glu Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met 
                 485                490                495
Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val 
             500                505                510
Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln 
         515                520                525
Asn Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly 
     530                535                540
Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro 
 545                550                555                560
Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                 565                570                575
Lys Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Asp Lys Leu Phe 
             580                585                590
Leu Asp Thr Leu Pro Phe 
         595



<210> 2842
<211> 1792
<212> DNA
<213> Rattus norvegicus
<308> L09653
<400> 2842

cccgaggct  gttcgcggc  ccccagggg  cggtctatg  cgagcgacg  gggctgcca  60
gggtcgggg  ctgctccgg  gcctgtggc  gctgcacat  gtcctgtgg  cgcgcatcg  120
cagcacgat  ccgccgcac  ttcccaagt  ggttaacag  gatctgatg  cgggtgaca  180
cagcggtgc  gtcaagctt  cacagctgt  caagttttg  gacgtgaca  tgtccactt  240
tgacaacca  aagtcttgc  tgagcaact  cagcgtcac  tccatctgt  agaagccgc  300
ggaagtctg  gtggccgtg  ggaggaaga  cgacaagaa  attactctg  agaccgttt  360
ccacgaccc  aagttcacc  accacggct  cactctgga  gatgccact  ctcccacgt  420
cgtcatgaa  gaaaagaaa  gggcgggcg  gaccttctt  atgtgctcc  gtaacacag  480
ggagtgtaa  gattacatc  tctttaatg  agaatacac  accagcagt  ctgacctgt  540
gctggtcat  atccaagtg  cgggcgtca  cctcctgcc  ccgctgggg  ttgccatag  600
tgtcattgc  atcttctac  gttaccgtg  ccaccggca  cagaagttg  gcccctcct  660
ggagagcag  aagccccgg  agctcatgg  tttcagcga  aactgcgcc  tcatcctgg  720
ggacgaccg  tctgacatc  gctctacgt  cgccaacaa  atcaaccac  atacggaac  780
gctgcccat  gagctggac  cgctggtgg  gaagggccg  ttcgccgag  tctacaagg  840
caagctgaa  cagaacact  cagagcagt  tgagaccgt  gctgtcaag  tcttcccct  900
cgaggaata  tcctcgtgg  aaacggaga  ggacatctt  tctgacatc  acctgaaac  960
cgagaacat  ctgcagttc  tgacggccg  ggagcggaa  acggagatg  gcaagcagt  1020
ctggctgat  acggcgttt  atgctaagg  caacctgca  gagtacctc  ctaggcacg  1080
catcagctg  gaggacctg  ggaagctgg  cagctccct  gcccggggc  tcgcccatc  1140
gcacagtga  cacactcct  gtgggaggc  caagatgcc  attgttcac  gggacctca  1200
gagctctaa  atcctagtg  agaacgatt  gacctgttg  ctgtgtgac  tcgggctgt  1260
cttgcgcct  gaccctact  tgtctgtgg  tgacctggc  aacagcggg  aggtgggaa  1320
agcgagata  atggccccg  aagttctag  atccaggat  aatttggag  acatggagt  1380
cttcaagca  acggatgtc  actccatgg  tctggtact  tgggaaatg  cgtctcgct  1440
caacgctgt  ggagaagtg  aagattatg  gcccccatt  ggttccaag  tgcgggagc  1500
cccctgtgt  gagagcatg  aagacaacg  gctgagaga  cgaggacgg  ctgaaatcc  1560
cagcttctg  ctcaaccac  agggcatcc  gatcgtgtg  gagacactg  ccgagtgct  1620
ggaccacga  cccgaggcc  gtctcacag  ccagtgtgt  gcagagcgc  tcagtgaac  1680
ggagcaccc  gatagactc  ccgggagga  ctgctccca  gagaagatt  cagaagacg  1740
ctccctgaa  actaccaaa  agctttttc  gggcaggct  ggccaagac  cc  1792



<210> 2843
<211> 567
<212> PRT
<213> Rattus norvegicus
<308> P38438
<400> 2843

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
  1               5                  10                  15
Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Pro Lys Ser Val 
             20                  25                  30
Asn Ser Asp Leu Met Ala Gly Asp Asn Ser Gly Ala Val Lys Leu Pro 
         35                  40                  45
Gln Leu Cys Lys Phe Cys Asp Val Thr Leu Ser Thr Cys Asp Asn Gln 
     50                  55                  60
Lys Ser Cys Met Ser Asn Cys Ser Val Thr Ser Ile Cys Glu Lys Pro 
 65                  70                  75                  80
Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Lys Asn Ile Thr 
                 85                  90                  95
Leu Glu Thr Val Cys His Asp Pro Lys Phe Thr Tyr His Gly Phe Thr 
             100                105                110
Leu Glu Asp Ala Thr Ser Pro Thr Cys Val Met Lys Glu Lys Lys Arg 
         115                120                125
Ala Gly Glu Thr Phe Phe Met Cys Ser Cys Asn Thr Glu Glu Cys Asn 
     130                135                140
Asp Tyr Ile Ile Phe Asn Glu Glu Tyr Thr Thr Ser Ser Pro Asp Leu 
 145                150                155                160
Leu Leu Val Ile Ile Gln Val Thr Gly Val Ser Leu Leu Pro Pro Leu 
                 165                170                175
Gly Ile Ala Ile Ala Val Ile Ala Ile Phe Tyr Cys Tyr Arg Val His 
             180                185                190
Arg Gln Gln Lys Leu Ser Pro Ser Trp Glu Ser Ser Lys Pro Arg Lys 
         195                200                205
Leu Met Asp Phe Ser Asp Asn Cys Ala Ile Ile Leu Glu Asp Asp Arg 
     210                215                220
Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
 225                230                235                240
Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                 245                250                255
Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
             260                265                270
Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ser Ser Trp Lys 
         275                280                285
Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
     290                295                300
Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Met Gly Lys Gln 
 305                310                315                320
Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                 325                330                335
Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
             340                345                350
Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
         355                360                365
Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
     370                375                380
Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
 385                390                395                400
Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                 405                410                415
Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
             420                425                430
Arg Met Asn Leu Glu Asn Met Glu Ser Phe Lys Gln Thr Asp Val Tyr 
         435                440                445
Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
     450                455                460
Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
 465                470                475                480
His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                 485                490                495
Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Ile 
             500                505                510
Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
         515                520                525
Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Pro 
     530                535                540
Asp Arg Leu Ser Gly Arg Ser Cys Ser Gln Glu Lys Ile Pro Glu Asp 
 545                550                555                560
Gly Ser Leu Asn Thr Thr Lys 
                 565



<210> 2844
<211> 2535
<212> DNA
<213> Rattus norvegicus
<308> L09656
<400> 2844

cgcccgggg  gccacgggc  gccaagccc  agagccgcc  gagccgctc  gactcaagc  60
ctcgcgcgg  cccgaggca  cccagccgc  ggcggcgcg  ggggagggg  aagcccgag  120
ccgcgctcc  gaccaaagt  aactttaat  gggaaggtt  gatgcggag  ccgggcggc  180
ggacctgct  gaagtagct  aagatgaat  cccagcagc  gcgcatggc  gcgataggg  240
ccgacaagg  gctgagcga  ctgctggac  tcagtgcga  gttttctcc  cctgttaat  300
gtgggaaaa  gagaccaac  acactggga  gtagtcagt  cagcgggtc  ggtatggat  360
agcgtggag  aacaacgtc  tggggaaca  gcggtcaac  aagcccctc  tatgattca  420
ctagaggtt  tacagacag  cctcattac  gtgatcact  gaatgacag  cgattagga  480
cccatgaag  cttgtcccc  acacctttc  tgaactcaa  tctgatagg  aaaacctca  540
agagaggct  attttccct  tacagcaga  actctggat  atcaggctg  cagtctagt  600
tcctgagac  agatctagg  ctcgggagc  cagcacagt  gtcttcttc  ggaaaacct  660
gaacaccat  ctactcatt  tctgccaca  gttctagaa  aagaccgct  catgattct  720
tagctctag  tcctttaca  gcaaagaaa  taagaaagg  gcctcctgg  ctaccttct  780
ctgtgtatg  accatcccc  aattctgac  atttcaacc  tgaatctcc  agttaccca  840
ctcccaagc  accaaccag  atgttcgct  gcactttct  tatgcaaga  ggcactcac  900
gttcttctg  cctttggag  tcatcgaat  ggatgagcc  gcctggttt  ggtggaatt  960
tggggacct  cacttccca  atgtctcag  ccagtagtt  tggcagtct  cattcacat  1020
accgcttga  ttatcctcc  cactcagtg  caccaacag  cataaacac  agtcttccg  1080
caatgtcca  cttccaccg  ggtagtacc  gcagctcac  atatgttgc  gcctcacat  1140
ctcctccca  caatggatc  gatagcatc  tgggaaccc  agggaatgc  gctggaagc  1200
cacagaccg  tgatgcact  gggaaggcc  tggcatcta  ttattctcc  gaccacaca  1260
gcagtagtt  tccatcaaa  ccatcaaca  cagtaggat  tccttcacc  ctcacagca  1320
gtaccagtc  gtggcccag  gctggaggg  aagctcctt  atccccaag  tatgaaaac  1380
cacttcact  cctgaaaaa  cgagttgag  agcaacttc  cgagcattt  caagatgca  1440
tgtccttct  aaaggatgt  tgtgagcag  ctcgaatgg  agaccgttt  gacaggctg  1500
atgatgcta  ccatgtgct  cggaaccat  cagttggac  ttctaccag  ctgcctact  1560
gccacagtg  tatacacag  ttattggga  catcccata  tgcaccaat  ggaaacctc  1620
attcaaact  tggaggatc  agccttgtt  caaatagtc  atcagcttc  atggtcgga  1680
ctcatcggg  agattcggt  agtctcaat  gcaatcatt  ggtcctgtc  agtactgtt  1740
ctgcctcaa  cacagaact  aaccataaa  caccagaaa  tttcagagg  ggtgtacaa  1800
atcagtctg  aagtgttgt  ccaacagaa  tcaagactg  aaacaaaga  aaagatgaa  1860
accttcatg  acctccttc  tcagatgac  tgaaatcag  tgatgagtc  tcccagaaa  1920
acatcaaag  ctcatctag  ggcagaaca  gcagtacca  tgaagatga  gatctgaat  1980
cagaacaga  aatcgaaag  gagaaggaa  ggcggatgg  taacaatgc  agagagcgc  2040
tgcgtgtgc  ggatatcaa  gaggcattc  aggagctcg  ccgaatgtg  cagcttcat  2100
tgaagagtg  gaaaccaca  acaaaactt  tcattcttc  tcaagccgt  gcagtcatc  2160
ttagtctag  acagcaagt  agagagagg  acctcaacc  caaagcagc  tgccttaag  2220
gaagagaag  agaaaaggt  tctgctgcg  cagcagagc  gcccaccac  ttgccagga  2280
cccatcctg  gcttagtga  acaaccaac  ctatgggtc  tctgtaaac  tcagccagt  2340
ccagagtca  cagtaggct  gatagaagg  gacctctcc  cataaagat  tggagaact  2400
agattatct  aagacacaa  cctggcagg  gggagaaga  aaagcaaaa  acttgaaac  2460
agaaactca  atgtaatcc  atgatcaaa  caactggtc  acacttcca  cagaagtga  2520
gataggaag  tgcgg  2535



<210> 2845
<211> 707
<212> PRT
<213> Rattus norvegicus
<308> P51514
<400> 2845

Met Asn Pro Gln Gln Gln Arg Met Ala Ala Ile Gly Thr Asp Lys Glu 
  1               5                  10                  15
Leu Ser Asp Leu Leu Asp Phe Ser Ala Met Phe Ser Pro Pro Val Asn 
             20                  25                  30
Ser Gly Lys Thr Arg Pro Thr Thr Leu Gly Ser Ser Gln Phe Ser Gly 
         35                  40                  45
Ser Gly Met Asp Glu Arg Gly Gly Thr Thr Ser Trp Gly Thr Ser Gly 
     50                  55                  60
Gln Pro Ser Pro Ser Tyr Asp Ser Ser Arg Gly Phe Thr Asp Ser Pro 
 65                  70                  75                  80
His Tyr Ser Asp His Leu Asn Asp Ser Arg Leu Gly Thr His Glu Gly 
                 85                  90                  95
Leu Ser Pro Thr Pro Phe Met Asn Ser Asn Leu Ile Gly Lys Thr Ser 
             100                105                110
Glu Arg Gly Ser Phe Ser Leu Tyr Ser Arg Asp Ser Gly Leu Ser Gly 
         115                120                125
Cys Gln Ser Ser Leu Leu Arg Gln Asp Leu Gly Leu Gly Ser Pro Ala 
     130                135                140
Gln Leu Ser Ser Ser Gly Lys Pro Gly Thr Pro Tyr Tyr Ser Phe Ser 
 145                150                155                160
Ala Thr Ser Ser Arg Arg Arg Pro Leu His Asp Ser Val Ala Leu Asp 
                 165                170                175
Pro Leu Gln Ala Lys Lys Val Arg Lys Val Pro Pro Gly Leu Pro Ser 
             180                185                190
Ser Val Tyr Ala Pro Ser Pro Asn Ser Asp Asp Phe Asn Arg Glu Ser 
         195                200                205
Pro Ser Tyr Pro Ser Pro Lys Pro Pro Thr Ser Met Phe Ala Ser Thr 
     210                215                220
Phe Phe Met Gln Asp Gly Thr His Ser Ser Ser Asp Leu Trp Ser Ser 
 225                230                235                240
Ser Asn Gly Met Ser Gln Pro Gly Phe Gly Gly Ile Leu Gly Thr Ser 
                 245                250                255
Thr Ser His Met Ser Gln Ser Ser Ser Tyr Gly Ser Leu His Ser His 
             260                265                270
Asp Arg Leu Ser Tyr Pro Pro His Ser Val Ser Pro Thr Asp Ile Asn 
         275                280                285
Thr Ser Leu Pro Pro Met Ser Ser Phe His Arg Gly Ser Thr Ser Ser 
     290                295                300
Ser Pro Tyr Val Ala Ala Ser His Thr Pro Pro Ile Asn Gly Ser Asp 
 305                310                315                320
Ser Ile Leu Gly Thr Arg Gly Asn Ala Ala Gly Ser Ser Gln Thr Gly 
                 325                330                335
Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr Ser Pro Asp His Thr 
             340                345                350
Ser Ser Ser Phe Pro Ser Asn Pro Ser Thr Pro Val Gly Ser Pro Ser 
         355                360                365
Pro Leu Thr Ala Gly Thr Ser Gln Trp Pro Arg Ala Gly Gly Gln Ala 
     370                375                380
Pro Ser Ser Pro Ser Tyr Glu Asn Ser Leu His Ser Leu Lys Asn Arg 
 385                390                395                400
Val Glu Gln Gln Leu His Glu His Leu Gln Asp Ala Met Ser Phe Leu 
                 405                410                415
Lys Asp Val Cys Glu Gln Ser Arg Met Glu Asp Arg Leu Asp Arg Leu 
             420                425                430
Asp Asp Ala Ile His Val Leu Arg Asn His Ala Val Gly Pro Ser Thr 
         435                440                445
Ser Leu Pro Thr Ser His Ser Asp Ile His Ser Leu Leu Gly Pro Ser 
     450                455                460
His Asn Ala Pro Ile Gly Asn Leu Asn Ser Asn Tyr Gly Gly Ser Ser 
 465                470                475                480
Leu Val Thr Asn Ser Arg Ser Ala Ser Met Val Gly Thr His Arg Glu 
                 485                490                495
Asp Ser Val Ser Leu Asn Gly Asn His Ser Val Leu Ser Ser Thr Val 
             500                505                510
Ala Ala Ser Asn Thr Glu Leu Asn His Lys Thr Pro Glu Ser Phe Arg 
         515                520                525
Gly Gly Val Gln Asn Gln Ser Gly Ser Val Val Pro Thr Glu Ile Lys 
     530                535                540
Thr Glu Asn Lys Glu Lys Asp Glu Asn Leu His Glu Pro Pro Ser Ser 
 545                550                555                560
Asp Asp Met Lys Ser Asp Asp Glu Ser Ser Gln Lys Asp Ile Lys Val 
                 565                570                575
Ser Ser Arg Gly Arg Thr Ser Ser Thr Asn Glu Asp Glu Asp Leu Asn 
             580                585                590
Pro Glu Gln Lys Ile Glu Arg Glu Lys Glu Arg Arg Met Ala Asn Asn 
         595                600                605
Ala Arg Glu Arg Leu Arg Val Arg Asp Ile Asn Glu Ala Phe Lys Glu 
     610                615                620
Leu Gly Arg Met Cys Gln Leu His Leu Lys Ser Glu Lys Pro Gln Thr 
 625                630                635                640
Lys Leu Leu Ile Leu His Gln Ala Val Ala Val Ile Leu Ser Leu Glu 
                 645                650                655
Gln Gln Val Arg Glu Arg Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys 
             660                665                670
Arg Arg Glu Glu Glu Lys Val Ser Ala Ala Ser Ala Glu Pro Pro Thr 
         675                680                685
Thr Leu Pro Gly Thr His Pro Gly Leu Ser Glu Thr Thr Asn Pro Met 
     690                695                700
Gly His Leu 
 705



<210> 2846
<211> 4202
<212> DNA
<213> Homo sapiens
<308> NM_003205
<400> 2846

taaagggac  gacagcccg  cccgggagg  aggggcgcc  ggcccgaaa  ccgcctccc  60
ctcccagac  cgagagctc  tgcggggca  agtgaaccg  gccgctggg  gtgcaaggg  120
aagcccaag  ccgttctcc  ggccaaagt  aactttaat  ggggtggtt  gatgcggag  180
cggggcggc  ggacctgct  gaagtggcc  aagatgaat  cccagcaac  acgcatggc  240
gctataggg  ccgacaagg  gctgagcga  ctactggac  tcagtgcga  gttttcccc  300
cctgttaat  gtgggaaaa  tagaccaac  acactggga  gcagtcaat  cagtggatc  360
ggtattgat  aaagaggag  tacaacatc  tggggaaca  gtggtcaac  aagtccttc  420
tatgattca  ctagaggtt  tacagacag  cctcattac  gtgatcact  gaatgacag  480
cgattagga  cccatgaag  cttgtcccc  acacctttc  tgaactcaa  tctgatggg  540
aaaacatca  agagaggct  attttccct  tacagcaga  atactggat  accaggctg  600
caatctagt  tcctgagac  agatctggg  cttgggagc  cagcacagc  atcttcttc  660
ggaaaacct  ggacagcat  ctattcatt  tctgctaca  gttccagga  gagaccact  720
catgactct  cagcgcttg  tcccttgca  gcaaaaaaa  tcagaaagg  gcctcctgg  780
ttgccttct  ctgtatatg  accatcccc  aattcagat  atttcaacc  tgaatctcc  840
agttatcca  ctcctaagc  accaaccag  atgttcgct  gcactttct  tatgcaaga  900
gggacccac  attcttctg  cctttggag  tcatcaaat  ggatgagcc  gcctggttt  960
ggtggaatt  tggggacct  cacttccca  atgtctcaa  ccagtagtt  tggcaacct  1020
cattcacat  accgcttga  ttatcctcc  cactcagtt  caccaacag  cataaacac  1080
agtcttcca  caatgtcca  ctttcatcg  ggcagtacc  gcagttcac  ttacgttgc  1140
gcctcacac  ctcctccca  caatggatc  gacagcatt  taggaacca  agggaatgc  1200
gctggaagc  cacagacag  tgatgcact  ggaaaggct  tggcatcta  ttattctcc  1260
gaccatacc  gcagtagtt  tccgtcaaa  ccatcaaca  cagttggat  accttcacc  1320
ctcacaggt  ccagtcagt  gccaagacc  ggagggcaa  caccttcat  cccaagcta  1380
gaaaactca  tccactccc  gcagtctcg  atggaggat  gtttagaca  actggatga  1440
gcaatccat  tgctgcgga  ccatgctgt  ggaccttcc  ccagtttgc  tgctggtca  1500
agtgatata  atagtttat  gggaccatc  cataatgca  caattggaa  cctcaattc  1560
aactatgga  gatcaagcc  tgttgcaag  agtcgatca  cttcaatgg  tggaactca  1620
cgggaagac  ctgtcagtc  caatggcaa  cattcagtc  tgtctagta  agtcactac  1680
tcaagcaca  acctgaacc  taaaacaca  gaaaattat  gaggtggct  gcaaagtca  1740
tctggaact  ttgttacaa  agaaatcaa  actgaaaac  aagaaaagg  tgaaaacct  1800
catgaacct  cttcatcag  tgacatgaa  tcagatgat  aatcctccc  aaaagatat  1860
aaggtttca  ctagaggca  aacaagcag  actaatgaa  atgaggatt  gaaccctga  1920
cagaagata  aaagggaga  ggagaggcg  atggctaac  atgccagag  acgcttacg  1980
gtgcgggat  ttaatgaag  attcaaaga  cttggccga  tgtgtcagc  tcacttgaa  2040
agtgaaaaa  cccaaacaa  actccttat  cttcatcaa  ccgtggcag  catccttag  2100
ctagaacag  aagtcagag  gaggaacct  aaccccaaa  cagcctgcc  taagagaag  2160
gaagaagaa  aagtttctg  cgtatcggc  gagccgcca  ccacactgc  aggaaccca  2220
cctgggctt  gtgaaacta  caaccctat  ggtcatatg  aaacatcag  cagttccag  2280
gttatcagt  ggctagata  aaggtgacc  ctcctcata  ggacttgga  aactcagat  2340
atctgaaga  acaaacctg  caggaggga  aagaaaaaa  aaaacactt  aaccaagaa  2400
ctcaaatgt  atcctacga  caaagcaac  ggtcaacac  tccatcaga  gtgaagata  2460
gaagctcat  agatagaac  tcagcccat  agatgtttg  aacaaatct  ttgttgcaa  2520
cagtgtgtc  cttctgcac  atcagagac  gtctcgatc  ctccactca  cgtggaagt  2580
gccttgtgc  taaactgaa  tgacaaatg  attgtaact  caaatttta  ttattgtta  2640
gaaactgta  ggtctacat  taaagggaa  aagttaatg  ggaaagctg  tctacactc  2700
gctgatgcc  gcatacatt  aagcggttc  cgtgcagag  acaaagcag  gacaaccat  2760
ggcccttag  attcccggc  tacctatta  tgtcttaaa  aggaaggga  aagtctttt  2820
ttgccctct  ctatcctct  gccatatga  tagcgtttt  catgaaata  gaaaatatt  2880
cttggtata  catttctct  gctctcatt  tttgattta  ttttatttt  tctttgtgg  2940
tgttatatt  gatctctaa  tctgaacag  ttatggtca  agtccagcc  cctccgtgc  3000
gccctgtgt  ctttgcaca  ttaccttac  gtggtaagc  gagaccatc  gtgaccata  3060
cctagctag  attttaaaa  gggaaattt  gttctctag  ttttccccc  aataaacat  3120
gctttattt  taataataa  caagacttt  caagcttct  gatctcata  gaaagcttg  3180
aatagcaaa  ttgtaaatt  caagggaag  atctacttt  tagaaatcg  tttgttttc  3240
aagcagtaa  tactacata  agtacttgt  aagtgttag  tgtaagtaa  cacaaaata  3300
atttaaaat  caaagacga  tttttcagg  tgtgattat  gtgaacata  caaaaccca  3360
tagtcacca  ggcaggtag  gtgataaat  aacacacca  tctgaggct  attacctaa  3420
ggaatacaa  agcaatggt  acccgtatt  ccttatcct  gcctttatt  ctctgtcat  3480
tggatggct  gtcaatggg  aagaattga  tgggtgatt  aatcaactg  aaaccatct  3540
cccctgtcc  aaaatgatg  gccagatta  cattaaacc  gtacttgtc  gtccatctt  3600
atactgttc  ttaaggcac  ctctgtctc  aatccttag  agttgtttt  aaagacata  3660
tcactttga  cttccatga  acctgtctt  caccacaac  accctggga  agaaaaaca  3720
gctaaagga  gtatcttgg  ttaataatt  cttatagcc  atatcaaca  tggcaatca  3780
cacacagag  aaaggaccc  aatcactat  tagcttaaa  atttctgtt  atttgaaag  3840
acaaaaaca  gacagaact  ctggtactc  aatcaggat  attcctaac  agtcagtca  3900
ttgtgaact  agtggactt  ttggttact  taatttgca  atattctcc  gttacatcg  3960
actctatct  tggccttgt  cttcatttc  gtgttaatc  gctaaacag  agttgttgc  4020
tatgatgtg  gagtgaaca  atgccactg  ctggccctt  tttcttcag  gcttgttgt  4080
tttttcgct  tattagact  tgcagtatg  ccagaagct  tccttcata  aatagaaag  4140
aaaaaacat  tggcttatt  ttcactgta  ctagtcttt  atacaataa  cttgtaaga  4200
aa  4202



<210> 2847
<211> 682
<212> PRT
<213> Homo sapiens
<308> Q99081
<400> 2847

Met Asn Pro Gln Gln Gln Arg Met Ala Ala Ile Gly Thr Asp Lys Glu 
  1               5                  10                  15
Leu Ser Asp Leu Leu Asp Phe Ser Ala Met Phe Ser Pro Pro Val Asn 
             20                  25                  30
Ser Gly Lys Thr Arg Pro Thr Thr Leu Gly Ser Ser Gln Phe Ser Gly 
         35                  40                  45
Ser Gly Ile Asp Glu Arg Gly Gly Thr Thr Ser Trp Gly Thr Ser Gly 
     50                  55                  60
Gln Pro Ser Pro Ser Tyr Asp Ser Ser Arg Gly Phe Thr Asp Ser Pro 
 65                  70                  75                  80
His Tyr Ser Asp His Leu Asn Asp Ser Arg Leu Gly Ala His Glu Gly 
                 85                  90                  95
Leu Ser Pro Thr Pro Phe Met Asn Ser Asn Leu Met Gly Lys Thr Ser 
             100                105                110
Glu Arg Gly Ser Phe Ser Leu Tyr Ser Arg Asp Thr Gly Leu Pro Gly 
         115                120                125
Cys Gln Ser Ser Leu Leu Arg Gln Asp Leu Gly Leu Gly Ser Pro Ala 
     130                135                140
Gln Leu Ser Ser Ser Gly Lys Pro Gly Thr Ala Tyr Tyr Ser Phe Ser 
 145                150                155                160
Ala Thr Ser Ser Arg Arg Arg Pro Leu His Asp Ser Ala Ala Leu Asp 
                 165                170                175
Pro Leu Gln Ala Lys Lys Val Arg Lys Val Pro Pro Gly Leu Pro Ser 
             180                185                190
Ser Val Tyr Ala Pro Ser Pro Asn Ser Asp Asp Phe Asn Arg Glu Ser 
         195                200                205
Pro Ser Tyr Pro Ser Pro Lys Pro Pro Thr Ser Met Phe Ala Ser Thr 
     210                215                220
Phe Phe Met Gln Asp Gly Thr His Asn Ser Ser Asp Leu Trp Ser Ser 
 225                230                235                240
Ser Asn Gly Met Ser Gln Pro Gly Phe Gly Gly Ile Leu Gly Thr Ser 
                 245                250                255
Thr Ser His Met Ser Gln Ser Ser Ser Tyr Gly Asn Leu His Ser His 
             260                265                270
Asp Arg Leu Ser Tyr Pro Pro His Ser Val Ser Pro Thr Asp Ile Asn 
         275                280                285
Thr Ser Leu Pro Pro Met Ser Ser Phe His Arg Gly Ser Thr Ser Ser 
     290                295                300
Ser Pro Tyr Val Ala Ala Ser His Thr Pro Pro Ile Asn Gly Ser Asp 
 305                310                315                320
Ser Ile Leu Gly Thr Arg Gly Asn Ala Ala Gly Ser Ser Gln Thr Gly 
                 325                330                335
Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr Ser Pro Asp His Thr 
             340                345                350
Ser Ser Ser Phe Pro Ser Asn Pro Ser Thr Pro Val Gly Ser Pro Ser 
         355                360                365
Pro Leu Thr Gly Thr Ser Gln Trp Pro Arg Pro Gly Gly Gln Ala Pro 
     370                375                380
Ser Ser Pro Ser Tyr Glu Asn Ser Leu His Ser Leu Gln Ser Arg Met 
 385                390                395                400
Glu Asp Arg Leu Asp Arg Leu Asp Asp Ala Ile His Val Leu Arg Asn 
                 405                410                415
His Ala Val Gly Pro Ser Thr Ser Leu Pro Ala Gly His Ser Asp Ile 
             420                425                430
His Ser Leu Leu Gly Pro Ser His Asn Ala Pro Ile Gly Ser Leu Asn 
         435                440                445
Ser Asn Tyr Gly Gly Ser Ser Leu Val Ala Ser Ser Arg Ser Ala Ser 
     450                455                460
Met Val Gly Thr His Arg Glu Asp Ser Val Ser Leu Asn Gly Asn His 
 465                470                475                480
Ser Val Leu Ser Ser Thr Val Thr Thr Ser Ser Thr Asp Leu Asn His 
                 485                490                495
Lys Thr Gln Glu Asn Tyr Arg Gly Gly Leu Gln Ser Gln Ser Gly Thr 
             500                505                510
Val Val Thr Thr Glu Ile Lys Thr Glu Asn Lys Glu Lys Asp Glu Asn 
         515                520                525
Leu His Glu Pro Pro Ser Ser Asp Asp Met Lys Ser Asp Asp Glu Ser 
     530                535                540
Ser Gln Lys Asp Ile Lys Val Ser Ser Arg Gly Arg Thr Ser Ser Thr 
 545                550                555                560
Asn Glu Asp Glu Asp Leu Asn Pro Glu Gln Lys Ile Glu Arg Glu Lys 
                 565                570                575
Glu Arg Arg Met Ala Asn Asn Ala Arg Glu Arg Leu Arg Val Arg Asp 
             580                585                590
Ile Asn Glu Ala Phe Lys Glu Leu Gly Arg Met Cys Gln Leu His Leu 
         595                600                605
Lys Ser Glu Lys Pro Gln Thr Lys Leu Leu Ile Leu His Gln Ala Val 
     610                615                620
Ala Val Ile Leu Ser Leu Glu Gln Gln Val Arg Glu Arg Asn Leu Asn 
 625                630                635                640
Pro Lys Ala Ala Cys Leu Lys Arg Arg Glu Glu Glu Lys Val Ser Ala 
                 645                650                655
Val Ser Ala Glu Pro Pro Thr Thr Leu Pro Gly Thr His Pro Gly Leu 
             660                665                670
Ser Glu Thr Thr Asn Pro Met Gly His Met 
         675                680



<210> 2848
<211> 2240
<212> DNA
<213> Rattus norvegicus
<308> L10073
<400> 2848

ggttcccag  gtgcaggca  cagtcccca  ttctgcagg  ggttggtta  tctgaagac  60
acaaagaga  tgggagagg  tgatgcgct  gacaaagct  gactaagga  tctcaactg  120
aaaaaaggg  ctacgaaaa  ctcaaaaaa  aagcgccta  agtttggaa  aagaacaaa  180
gtggcgcgg  ttagacttc  ttttgtgtt  ctgggctcg  gcagtgccc  tcctgcctc  240
ccacctaac  acagttcat  caatcacgg  cacatctgc  agagagccc  agtccctga  300
caatggaag  ctctaacct  tcaggcgcc  cccctggca  tgcctttcc  ccgggaccc  360
agagctgca  tgacagccc  agttccggc  gaagcatgg  atccacccc  ggggggctc  420
tcttgtccg  ccgcgagcc  cccttctct  ccttcaccg  actcgtggt  actctactg  480
tgttgctga  cgctgccac  ttcttatgg  atctgctag  tctggtgac  atcctgcgc  540
tccgcgcct  ccaccgtgt  ccacataac  tggtagcct  gaccgccgt  tcggacgtc  600
tggtggcgg  tctggtgat  ccactgagc  tggtgagcg  gttgtcggc  gggcgacgt  660
ggcagctgg  caggagtct  tgccacgtg  ggatctcct  cgacgtgtt  tgctgcaca  720
ccagcatct  gaacgtggc  gccatcgcc  tggatcgct  ctggactat  acgcgccac  780
tgcagtaca  gctgcgcac  cggcgccgc  cttcagcac  tatgatcgc  atcacctgg  840
cactgtccg  cctcatcgc  ctcgccccg  tgctctttg  ctggggcga  gcctacgat  900
ctcggctgc  gcgttgcca  gtgagccag  agccttcgt  cgccgtctt  tccacctgc  960
gagctttct  cgtgcctct  gccgtggtg  tcttcgtct  ctggaagat  tacaaagcc  1020
ccaagtttc  attcggccg  agacggcgg  cggtagtgc  cctgcccgc  accacgcag  1080
caaaggaag  acctcagga  tctgagacg  tattcaccg  gcgttgcag  gcgacagtg  1140
ccttccaga  aagtggaga  tcctggcgg  agcagaagg  gaagcgagc  gccatgatg  1200
tggggatct  gatcggtgt  tttgtgctg  gctggatcc  cttcttcct  acggagctc  1260
tcagcccgc  ctgcgcctg  agcctgcca  ccatctgga  aagcatatt  ctgtggctt  1320
gctattcaa  ttcgttctt  aatccctta  tctacacgg  ctttaataa  aactacaac  1380
atgccttca  gagcctctt  actaagcag  gataagcag  gctggggag  taaaaagga  1440
gaccgggga  gagaaaggg  atctgccgt  ctcatttca  cagagacct  ggggcttct  1500
cccgccgcc  acacccccc  aacgacact  cagaaatca  accgtaggg  ctggaatgt  1560
gagttctca  gaaggtaga  aacggtttg  caaatacat  catgccttc  acgcgtcgt  1620
acagacatt  ctagtgaat  gtgctacat  tctgcacca  gcaggaacc  cgccaaacc  1680
tttccgggt  tattttagg  attattgct  atttgtcag  ctccacatg  ggcagagtt  1740
atttgcttt  gcgttagta  tatgtccct  agtgagggt  tcttggggc  ctcctgaga  1800
tgactcctt  acatagcct  tcctctacc  cttatccat  agagcactt  acctttctt  1860
gcctcacac  ggacctcca  aaggcaatg  ttctcagtt  aggaagaga  gtcctcgcc  1920
gaagctttg  taaaaagtg  tccacacag  cgtcgtcaa  atggctcag  agagggggt  1980
ggggattta  ctcagtggt  gagcccttg  ctagggagc  caaggccct  ggttcggtc  2040
ccagctccg  aaaaaagaa  caaaaaaaa  aaaaaaaaa  aaaaaagat  gctcagtag  2100
tgaaggcgc  tgtccccaa  cctggtggc  tgcttttga  atacatgta  tggaaggaa  2160
taaaatgat  gcaagttgt  tctgacctc  agatatgtg  catcagccc  ctcccccat  2220
tgcacagcg  ccgcgaattc  2240



<210> 2849
<211> 370
<212> PRT
<213> Rattus norvegicus
<308> P35365
<400> 2849

Met Glu Val Ser Asn Leu Ser Gly Ala Thr Pro Gly Ile Ala Phe Pro 
  1               5                  10                  15
Pro Gly Pro Glu Ser Cys Ser Asp Ser Pro Ser Ser Gly Arg Ser Met 
             20                  25                  30
Gly Ser Thr Pro Gly Gly Leu Ile Leu Ser Gly Arg Glu Pro Pro Phe 
         35                  40                  45
Ser Ala Phe Thr Val Leu Val Val Thr Leu Leu Val Leu Leu Ile Ala 
     50                  55                  60
Ala Thr Phe Leu Trp Asn Leu Leu Val Leu Val Thr Ile Leu Arg Val 
 65                  70                  75                  80
Arg Ala Phe His Arg Val Pro His Asn Leu Val Ala Ser Thr Ala Val 
                 85                  90                  95
Ser Asp Val Leu Val Ala Ala Leu Val Met Pro Leu Ser Leu Val Ser 
             100                105                110
Glu Leu Ser Ala Gly Arg Arg Trp Gln Leu Gly Arg Ser Leu Cys His 
         115                120                125
Val Trp Ile Ser Phe Asp Val Leu Cys Cys Thr Ala Ser Ile Trp Asn 
     130                135                140
Val Ala Ala Ile Ala Leu Asp Arg Tyr Trp Thr Ile Thr Arg His Leu 
 145                150                155                160
Gln Tyr Thr Leu Arg Thr Arg Arg Arg Ala Ser Ala Leu Met Ile Ala 
                 165                170                175
Ile Thr Trp Ala Leu Ser Ala Leu Ile Ala Leu Ala Pro Leu Leu Phe 
             180                185                190
Gly Trp Gly Glu Ala Tyr Asp Ala Arg Leu Gln Arg Cys Gln Val Ser 
         195                200                205
Gln Glu Pro Ser Tyr Ala Val Phe Ser Thr Cys Gly Ala Phe Tyr Val 
     210                215                220
Pro Leu Ala Val Val Leu Phe Val Tyr Trp Lys Ile Tyr Lys Ala Ala 
 225                230                235                240
Lys Phe Arg Phe Gly Arg Arg Arg Arg Ala Val Val Pro Leu Pro Ala 
                 245                250                255
Thr Thr Gln Ala Lys Glu Ala Pro Gln Glu Ser Glu Thr Val Phe Thr 
             260                265                270
Ala Arg Cys Arg Ala Thr Val Ala Phe Gln Thr Ser Gly Asp Ser Trp 
         275                280                285
Arg Glu Gln Lys Glu Lys Arg Ala Ala Met Met Val Gly Ile Leu Ile 
     290                295                300
Gly Val Phe Val Leu Cys Trp Ile Pro Phe Phe Leu Thr Glu Leu Val 
 305                310                315                320
Ser Pro Leu Cys Ala Cys Ser Leu Pro Pro Ile Trp Lys Ser Ile Phe 
                 325                330                335
Leu Trp Leu Gly Tyr Ser Asn Ser Phe Phe Asn Pro Leu Ile Tyr Thr 
             340                345                350
Ala Phe Asn Lys Asn Tyr Asn Asn Ala Phe Lys Ser Leu Phe Thr Lys 
         355                360                365
Gln Arg 
     370



<210> 2850
<211> 1074
<212> DNA
<213> Homo sapiens
<308> NM_024012
<400> 2850

atggattta  cagtgaacc  aacctcctt  tccctctcc  ccccctccc  tttggagac  60
aaccacagc  tcggcaaag  cgacctgcg  cccagctcg  ccctgctct  ggtcttcgg  120
gtgcttatt  tcaccttgc  gggctttct  gtggcggcg  cgttcgcct  gaacctgct  180
gtgctggcg  ccatcctcc  tgtacgcac  ttccaccgc  tgccccaca  cctggtggc  240
tccatggcc  tctcggatg  cctggtggc  gcgctggtc  tgccgctga  cctggtgca  300
gagctgtcc  ggcgccgct  gcagctagg  cggaggctg  gccagcttt  gatcgcgtg  360
gacgtgctt  gctgcacgg  cagcatctg  aacgtgacg  ccatagccc  ggaccgcta  420
tggtccatc  cgcgccaca  ggaatacac  ctccgcacc  gcaagtgcg  ctccaacgt  480
atgatcgcg  tcacctggg  actctccgc  gtcatctct  tggccccgc  gctttttgg  540
tggggagag  cgtactctg  gggcagcga  gagtgccag  taagccgcg  gccttccta  600
gccgtgttc  ccaccgtag  cgccttcta  ctgccgctc  gtgtggtgc  cttcgtgta  660
tggaagatc  acaaggctg  caagttccg  gtgggctcc  ggaagacca  tagcgtctc  720
cccatatcc  aagctgtgg  ggtgaagga  tctgccaaa  agccccaga  ggtgttcac  780
gtccgccac  ccaccgtca  cttccagcc  gaaggggac  cgtggcggg  gcagaagga  840
cagcgggcc  ccctcatgg  gggcatcct  attggcgtg  tcgtgctct  ctggatccc  900
ttctttctc  ccgagctca  cagtcccct  tgctcctgt  acatccccg  catctggaa  960
agcatcttc  tgtggcttg  ctactccaa  tccttcttt  accccctga  ctatacggc  1020
ttcaacaag  actacaaca  cgccttcaa  aacttcttt  ctaggcaac  ctga  1074



<210> 2851
<211> 357
<212> PRT
<213> Homo sapiens
<308> NP_076917
<400> 2851

Met Asp Leu Pro Val Asn Leu Thr Ser Phe Ser Leu Ser Thr Pro Ser 
  1               5                  10                  15
Pro Leu Glu Thr Asn His Ser Leu Gly Lys Asp Asp Leu Arg Pro Ser 
             20                  25                  30
Ser Pro Leu Leu Ser Val Phe Gly Val Leu Ile Leu Thr Leu Leu Gly 
         35                  40                  45
Phe Leu Val Ala Ala Thr Phe Ala Trp Asn Leu Leu Val Leu Ala Thr 
     50                  55                  60
Ile Leu Arg Val Arg Thr Phe His Arg Val Pro His Asn Leu Val Ala 
 65                  70                  75                  80
Ser Met Ala Val Ser Asp Val Leu Val Ala Ala Leu Val Met Pro Leu 
                 85                  90                  95
Ser Leu Val His Glu Leu Ser Gly Arg Arg Trp Gln Leu Gly Arg Arg 
             100                105                110
Leu Cys Gln Leu Trp Ile Ala Cys Asp Val Leu Cys Cys Thr Ala Ser 
         115                120                125
Ile Trp Asn Val Thr Ala Ile Ala Leu Asp Arg Tyr Trp Ser Ile Thr 
     130                135                140
Arg His Met Glu Tyr Thr Leu Arg Thr Arg Lys Cys Val Ser Asn Val 
 145                150                155                160
Met Ile Ala Leu Thr Trp Ala Leu Ser Ala Val Ile Ser Leu Ala Pro 
                 165                170                175
Leu Leu Phe Gly Trp Gly Glu Thr Tyr Ser Glu Gly Ser Glu Glu Cys 
             180                185                190
Gln Val Ser Arg Glu Pro Ser Tyr Ala Val Phe Ser Thr Val Gly Ala 
         195                200                205
Phe Tyr Leu Pro Leu Cys Val Val Leu Phe Val Tyr Trp Lys Ile Tyr 
     210                215                220
Lys Ala Ala Lys Phe Arg Val Gly Ser Arg Lys Thr Asn Ser Val Ser 
 225                230                235                240
Pro Ile Ser Glu Ala Val Glu Val Lys Asp Ser Ala Lys Gln Pro Gln 
                 245                250                255
Met Val Phe Thr Val Arg His Ala Thr Val Thr Phe Gln Pro Glu Gly 
             260                265                270
Asp Thr Trp Arg Glu Gln Lys Glu Gln Arg Ala Ala Leu Met Val Gly 
         275                280                285
Ile Leu Ile Gly Val Phe Val Leu Cys Trp Ile Pro Phe Phe Leu Thr 
     290                295                300
Glu Leu Ile Ser Pro Leu Cys Ser Cys Asp Ile Pro Ala Ile Trp Lys 
 305                310                315                320
Ser Ile Phe Leu Trp Leu Gly Tyr Ser Asn Ser Phe Phe Asn Pro Leu 
                 325                330                335
Ile Tyr Thr Ala Phe Asn Lys Asn Tyr Asn Ser Ala Phe Lys Asn Phe 
             340                345                350
Phe Ser Arg Gln His 
         355



<210> 2852
<211> 733
<212> DNA
<213> Rattus norvegicus
<308> L10326
<400> 2852

ccgcgcccc  ccgccgcca  gggctgcct  ggcaacagt  agaccgagg  ccagcgcaa  60
gaggagaag  cgcagcgcg  ggccaacaa  aagatcgag  agcagctgc  gaaggacaa  120
caggtctac  gggccacgc  ccgcctgct  ctgctgggt  ctggagagt  tggcaaaag  180
accattgtg  agcagatga  gatcctaca  gttaatggg  ttaacggag  gggcggcga  240
gaggacccg  aggctgcaa  gagcaacag  gatggagtc  attaccccc  ctagatgat  300
gctacagtc  tccatcttc  ctatgtcct  ccccagtta  cccattttg  atgctggaa  360
tgcccggtc  taggaaact  ctaataaga  tactattct  ttgtctggg  gggggggag  420
ggggatggg  ccctaacct  ttacctaac  tttaggcgt  aagtaaaaa  agaaagatg  480
gatgaagtc  ttaattggc  acagtgtag  agaacagca  tcagaaaac  catcgatat  540
ttgataatc  gctgtacca  aagttggca  ctgagaagt  tggcaagcc  ctactgaga  600
agcctccta  gtaatgtgt  ctgtgctaa  cccttcaac  ctactaata  ctgcacgtt  660
ttcttccta  gactctaca  gtaaaaata  gtattaaca  tcctgataa  taaaactct  720
tgcatgttt  agc  733



<210> 2853
<211> 394
<212> PRT
<213> Rattus norvegicus
<308> P04894
<400> 2853

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
  1               5                  10                  15
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
             20                  25                  30
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
         35                  40                  45
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
     50                  55                  60
Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala 
 65                  70                  75                  80
Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val Gln Asp Ile Lys 
                 85                  90                  95
Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn 
             100                105                110
Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg Val 
         115                120                125
Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asn Phe Asp Phe Pro Pro 
     130                135                140
Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg 
 145                150                155                160
Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln 
                 165                170                175
Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val Pro 
             180                185                190
Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe 
         195                200                205
Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe Asp Val 
     210                215                220
Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn Asp 
 225                230                235                240
Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met Val 
                 245                250                255
Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn Leu 
             260                265                270
Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val Ile 
         275                280                285
Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala Gly 
     290                295                300
Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr Thr 
 305                310                315                320
Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr Arg 
                 325                330                335
Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala Ser 
             340                345                350
Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val Asp 
         355                360                365
Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile Gln 
     370                375                380
Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
 385                390



<210> 2855
<211> 684
<212> PRT
<213> Rattus norvegicus
<308> L10362
<400> 2855

Met Asp Asp Tyr Arg Tyr Arg Asp Asn Tyr Glu Gly Tyr Ala Pro Asn 
  1               5                  10                  15
Asp Gly Tyr Tyr Arg Gly Asn Glu Gln Asn Pro Glu Glu Asp Ala Gln 
             20                  25                  30
Ser Asp Val Thr Glu Gly His Asp Glu Glu Asp Glu Ile Tyr Glu Gly 
         35                  40                  45
Glu Tyr Gln Gly Ile Pro His Pro Asp Asp Val Lys Ser Lys Gln Thr 
     50                  55                  60
Lys Met Ala Pro Ser Arg Ala Asp Gly Leu Arg Gly Gln Ala Asp Leu 
 65                  70                  75                  80
Met Ala Glu Arg Met Glu Asp Glu Glu Gln Leu Ala His Gln Tyr Glu 
                 85                  90                  95
Thr Ile Ile Asp Glu Cys Gly His Gly Arg Phe Gln Trp Thr Leu Phe 
             100                105                110
Phe Val Leu Val Leu Ala Leu Met Ala Asp Gly Val Glu Val Phe Val 
         115                120                125
Val Ser Phe Ala Leu Pro Ser Ala Glu Lys Asp Met Cys Leu Ser Ser 
     130                135                140
Ser Lys Lys Gly Met Leu Gly Leu Ile Val Tyr Leu Gly Met Met Ala 
 145                150                155                160
Gly Ala Phe Ile Leu Gly Gly Leu Ala Asp Lys Leu Gly Arg Lys Lys 
                 165                170                175
Val Leu Ser Met Ser Leu Ala Ile Asn Ala Ser Phe Ala Ser Leu Ser 
             180                185                190
Ser Phe Val Gln Gly Tyr Gly Ala Phe Leu Phe Cys Arg Leu Ile Ser 
         195                200                205
Gly Ile Gly Ile Gly Gly Ser Leu Pro Ile Val Phe Ala Tyr Phe Ser 
     210                215                220
Glu Phe Leu Ser Arg Glu Lys Arg Gly Glu His Leu Ser Trp Leu Gly 
 225                230                235                240
Ile Phe Trp Met Thr Gly Gly Ile Tyr Ala Ser Ala Met Ala Trp Ser 
                 245                250                255
Ile Ile Pro His Tyr Gly Trp Gly Phe Ser Met Gly Thr Asn Tyr His 
             260                265                270
Phe His Ser Trp Arg Val Phe Val Ile Val Cys Ala Leu Pro Ala Thr 
         275                280                285
Val Ser Met Val Ala Leu Lys Phe Met Pro Glu Ser Pro Arg Phe Leu 
     290                295                300
Leu Glu Met Gly Lys His Asp Glu Ala Trp Met Ile Leu Lys Gln Val 
 305                310                315                320
His Asp Thr Asn Met Arg Ala Lys Gly Thr Pro Glu Lys Val Phe Thr 
                 325                330                335
Val Ser His Ile Lys Thr Pro Lys Gln Met Asp Glu Phe Ile Glu Ile 
             340                345                350
Gln Ser Ser Thr Gly Thr Trp Tyr Gln Arg Trp Leu Val Arg Phe Met 
         355                360                365
Thr Ile Phe Lys Gln Val Trp Asp Asn Ala Leu Tyr Cys Val Met Gly 
     370                375                380
Pro Tyr Arg Met Asn Thr Leu Ile Leu Ala Val Val Trp Phe Thr Met 
 385                390                395                400
Ala Leu Ser Tyr Tyr Gly Leu Thr Val Trp Phe Pro Asp Met Ile Arg 
                 405                410                415
Tyr Phe Gln Asp Glu Glu Tyr Lys Ser Lys Met Lys Val Phe Phe Gly 
             420                425                430
Glu His Val His Gly Ala Thr Ile Asn Phe Thr Met Glu Asn Gln Ile 
         435                440                445
His Gln His Gly Lys Leu Val Asn Asp Lys Phe Ile Lys Met Tyr Phe 
     450                455                460
Lys His Val Leu Phe Glu Asp Thr Phe Phe Asp Lys Cys Tyr Phe Glu 
 465                470                475                480
Asp Val Thr Ser Thr Asp Thr Tyr Phe Lys Asn Cys Thr Ile Glu Ser 
                 485                490                495
Thr Thr Phe Tyr Asn Thr Asp Leu Tyr Lys His Lys Phe Ile Asp Cys 
             500                505                510
Arg Phe Ile Asn Ser Thr Phe Leu Glu Gln Lys Glu Gly Cys His Met 
         515                520                525
Asp Phe Glu Glu Asp Asn Asp Phe Leu Ile Tyr Leu Val Ser Phe Leu 
     530                535                540
Gly Ser Leu Ser Val Leu Pro Gly Asn Ile Ile Ser Ala Leu Leu Met 
 545                550                555                560
Asp Arg Ile Gly Arg Leu Lys Met Ile Gly Gly Ser Met Leu Ile Ser 
                 565                570                575
Ala Val Cys Cys Phe Phe Leu Phe Phe Gly Asn Ser Glu Ser Ala Met 
             580                585                590
Ile Gly Trp Gln Cys Leu Phe Cys Gly Thr Ser Ile Ala Ala Trp Asn 
         595                600                605
Ala Leu Asp Val Ile Thr Val Glu Leu Tyr Pro Thr Asn Gln Arg Ala 
     610                615                620
Thr Ala Phe Gly Ile Leu Asn Gly Leu Cys Lys Leu Gly Ala Ile Leu 
 625                630                635                640
Gly Asn Thr Ile Phe Ala Ser Phe Val Gly Ile Thr Lys Val Val Pro 
                 645                650                655
Ile Leu Leu Ala Ala Ala Ser Leu Val Gly Gly Gly Leu Val Ala Leu 
             660                665                670
Arg Leu Pro Glu Thr Arg Glu Gln Val Leu Met Ter 
         675                680



<210> 2857
<211> 216
<212> PRT
<213> Homo sapiens
<308> AK000592
<400> 2857

Met Lys Arg Lys Glu Ser Ala Phe Lys Ser Met Leu Lys Gln Ala Ala 
  1               5                  10                  15
Pro Pro Ile Glu Leu Asp Ala Val Trp Glu Asp Ile Arg Glu Arg Phe 
             20                  25                  30
Val Lys Glu Pro Ala Phe Glu Asp Ile Thr Leu Glu Pro Glu Arg Lys 
         35                  40                  45
Arg Ile Phe Lys Asp Phe Met His Val Leu Glu His Glu Cys Gln His 
     50                  55                  60
His His Ser Lys Asn Lys Lys His Ser Lys Lys Ser Lys Lys His His 
 65                  70                  75                  80
Arg Lys Arg Ser Arg Ser Arg Ser Gly Ser Asp Ser Asp Asp Asp Asp 
                 85                  90                  95
Ser His Ser Lys Lys Lys Arg Gln Arg Ser Glu Ser Arg Ser Ala Ser 
             100                105                110
Glu His Ser Ser Ser Ala Glu Ser Glu Arg Ser Tyr Lys Lys Ser Lys 
         115                120                125
Lys His Lys Lys Lys Ser Lys Lys Arg Arg His Lys Ser Asp Ser Pro 
     130                135                140
Glu Ser Asp Ala Glu Arg Glu Lys Asp Lys Lys Glu Lys Asp Arg Glu 
 145                150                155                160
Ser Glu Lys Asp Arg Thr Arg Gln Arg Ser Glu Ser Lys His Lys Ser 
                 165                170                175
Pro Lys Lys Lys Thr Gly Lys Asp Ser Gly Asn Trp Asp Thr Ser Gly 
             180                185                190
Ser Glu Leu Ser Glu Gly Glu Leu Glu Lys Arg Arg Arg Thr Leu Leu 
         195                200                205
Glu Gln Leu Asp Asp Asp Gln Ter 
     210                215



<210> 2858
<211> 2798
<212> DNA
<213> Rattus norvegicus
<308> L10669
<400> 2858

atttttgta  atttttatc  attattaaa  cttctcttc  aaaaaaaaa  aaaaaaaaagtccaggcc  ctttcagac  aggataaga  aaagcaaat  agtgttcgt  gcctagccg  60
cgtggaaaa  gtgtctgac  tgaaaaaga  cttcaaccg  cacctacat  tcaccctgg  120
caaggatcg  aatgtggcc  ctccgagag  ttactattt  gcactggct  acaccgtgc  180
ggaccacct  gtggaccgc  ggatccgca  acagcagca  tactatgcg  aggacccca  240
gaggattta  tacctgtct  tggagttgt  catggggag  acactgcag  acaccatgg  300
gaacctggc  ttggagaat  cctgcgatg  ggccaccta  cagctgggt  tggacatgg  360
ggagctgga  gagatcgag  aggatgcag  gttgggcaa  ggaggcctg  gacgcctgg  420
agcttgctt  ctggactcc  tggctacac  ggggctagc  gcctatggc  acgggatcc  480
ctatgagtt  gggattttt  atcagaaga  ctgtggggg  tggcagatg  aagaagctg  540
tgactggct  cgctatggc  acccctggg  gaaggcccg  ccagagttc  cgctgcctg  600
gcacttcta  ggtcgagtg  agcacacca  tcagggtgc  aagtgggtg  acacacagg  660
agtgttggc  atgccctat  acactcctg  gcctggcta  cgaaacaac  ttgtcaaca  720
catgcgcct  tggtcggcc  aggcacctc  ttacttcaa  ctcaaggac  tcaacgttg  780
cggctacat  caggccgtg  tggaccgaa  cctggctga  aacatctca  gtgttttgt  840
ccccaatga  aagttcttt  aagggaagg  attgcggct  aagcaggag  actttgtgg  900
ggccgccac  ctccaggac  tcattcgcc  tttcaagtc  tccaagttt  gctgccgtg  960
tcctgtgcg  acaaacttt  atgctttcc  tgataaggt  gccatccag  tcaacgaca  1020
ccacccttc  ttggccatc  ctgaactta  taggattct  gtggacctg  aacgactgg  1080
ctgggacaa  gcctgggat  tgacagtga  gacctgtgc  tacaccaac  acacagtgc  1140
gcctgaagc  ctggagcgc  ggccagtgc  cctcatgga  acactgctt  cccgccatc  1200
gcagatcat  tatgagatc  accagcgtt  ccttaatcg  gtggcggcc  cattccctg  1260
ggacgtaga  aggctgcgg  gcatgtcac  cgtggagga  ggagcggtg  aacgcatca  1320
catggcaca  ttgtgcatt  ctggttccc  cgcagtcaa  ggtgtggct  gcatccatt  1380
ggagatcct  aagaaaacc  tcttcaagg  cttttatga  ctggagcct  acaagttcc  1440
gaacaagac  aatggcatc  cccctcggc  ctggttggt  ctgtgtaac  ctgggctgg  1500
agaggtcat  gctgagcgc  tcggtgagg  gtacatctc  gatcttgac  agctacgca  1560
gctgctctc  tatctggat  atcaagcct  tatccgtga  gtggccaaa  tcaaacagg  1620
aaacaagct  aaattctct  cctacctgg  gaccgaata  aaagtccac  tcaacccca  1680
ctccctctt  gacgtccag  tgaagagga  tcatgagta  aaacgccag  ttctcaatt  1740
ccttcacat  atcaccttg  ataaccgca  caaaaggga  cccaatagg  tcatggtgc  1800
aaggactat  atgattgga  gcaaggctg  acccgggta  cacatggct  agatgatca  1860
caagcttat  accgccatt  gggatgtgg  caaccacga  cctgcggtg  gagaccgct  1920
ccgagtgat  ttcctggag  actaccgag  ctcactggc  gagaaagtt  ttcccgctg  1980
tgacctctc  gagcagatc  ccaccgcgg  cactgaggc  tcaggcact  gcaacatga  2040
gttcatgct  aacggggct  tgaccatcg  caccatgga  ggtgccaac  tggagatgg  2100
agaggaggc  ggggaagat  acttcttca  cttcggcat  cgggtggag  acgtggaaa  2160
gctggacca  agagggtac  atgcccagg  atactacga  cggattcct  agcttcggc  2220
gatcatcga  cagttaagc  gtggcttct  ctcccctaa  cagcctgac  tgttcaagg  2280
catcgtcaa  atggtcatg  accatgacc  gttcaaagt  tttgcagat  atgaggaat  2340
cattaaatg  caggacaaa  tcagtgagt  gtacaagaa  ccaagagag  ggacacgga  2400
ggtgatcag  aacatagcc  cctctggca  gttttccag  gaccgtacc  ttgcccagt  2460
tgcccggga  atctggggt  ttgaacctt  tcgtcagcg  ctgccagcc  cagatgaga  2520
gatctgagc  tccacacca  accccatac  tgcctttga  tctgtttgc  attcccgga  2580
tcaggccca  tccaggggt  gggcccctg  aattacatc  gggcccccc  ttttggaag  2640
ctcttttac  agtctctag  tcctgatgc  agtgtgact  aagaccctg  cctcttctt  2700
tccctcaac  ccctacccc  tttatttat  tatggggtc  aaccaatgc  cccactccc  2760
caataaatc  actctccat  accttcctt  aaaaaaaa  2798



<210> 2859
<211> 842
<212> PRT
<213> Rattus norvegicus
<308> AAA41253
<400> 2859

Met Ser Arg Pro Leu Ser Asp Gln Asp Lys Arg Lys Gln Ile Ser Val 
  1               5                  10                  15
Arg Gly Leu Ala Gly Val Glu Asn Val Ser Asp Leu Lys Lys Asn Phe 
             20                  25                  30
Asn Arg His Leu His Phe Thr Leu Val Lys Asp Arg Asn Val Ala Thr 
         35                  40                  45
Pro Arg Asp Tyr Tyr Phe Ala Leu Ala His Thr Val Arg Asp His Leu 
     50                  55                  60
Val Asp Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Ala Lys Asp Pro 
 65                  70                  75                  80
Lys Arg Ile Tyr Tyr Leu Ser Leu Glu Leu Tyr Met Gly Arg Thr Leu 
                 85                  90                  95
Gln Asn Thr Met Val Asn Leu Ala Leu Glu Asn Ala Cys Asp Glu Ala 
             100                105                110
Thr Tyr Gln Leu Gly Leu Asp Met Glu Glu Leu Glu Glu Ile Glu Glu 
         115                120                125
Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe 
     130                135                140
Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile 
 145                150                155                160
Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile Cys Gly Gly Trp Gln 
                 165                170                175
Met Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys 
             180                185                190
Ala Arg Pro Glu Phe Thr Leu Pro Val His Phe Tyr Gly Arg Val Glu 
         195                200                205
His Thr Ser Gln Gly Ala Lys Trp Val Asp Thr Gln Val Val Leu Ala 
     210                215                220
Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Arg Asn Asn Val Val Asn 
 225                230                235                240
Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Pro Tyr Phe Asn Leu Lys 
                 245                250                255
Asp Phe Asn Val Gly Gly Tyr Ile Gln Ala Val Leu Asp Arg Asn Leu 
             260                265                270
Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Lys Phe Phe Glu 
         275                280                285
Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr 
     290                295                300
Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser Lys Phe Gly Cys Arg 
 305                310                315                320
Asp Pro Val Arg Thr Asn Phe Asp Ala Phe Pro Asp Lys Val Ala Ile 
                 325                330                335
Gln Leu Asn Asp Thr His Pro Ser Leu Ala Ile Pro Glu Leu Ile Arg 
             340                345                350
Ile Leu Val Asp Leu Glu Arg Leu Asp Trp Asp Lys Ala Trp Asp Val 
         355                360                365
Thr Val Lys Thr Cys Ala Tyr Thr Asn His Thr Val Leu Pro Glu Ala 
     370                375                380
Leu Glu Arg Trp Pro Val His Leu Met Glu Thr Leu Leu Pro Arg His 
 385                390                395                400
Leu Gln Ile Ile Tyr Glu Ile Asn Gln Arg Phe Leu Asn Arg Val Ala 
                 405                410                415
Ala Ala Phe Pro Gly Asp Val Asp Arg Leu Arg Arg Met Ser Leu Val 
             420                425                430
Glu Glu Gly Ala Val Lys Arg Ile Asn Met Ala His Leu Cys Ile Ala 
         435                440                445
Gly Ser His Ala Val Asn Gly Val Ala Arg Ile His Ser Glu Ile Leu 
     450                455                460
Lys Lys Thr Ile Phe Lys Asp Phe Tyr Glu Leu Glu Pro His Lys Phe 
 465                470                475                480
Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Val Leu Cys 
                 485                490                495
Asn Pro Gly Leu Ala Glu Val Ile Ala Glu Arg Ile Gly Glu Glu Tyr 
             500                505                510
Ile Ser Asp Leu Asp Gln Leu Arg Lys Leu Leu Ser Tyr Leu Asp Asp 
         515                520                525
Gln Ala Phe Ile Arg Asp Val Ala Lys Val Lys Gln Glu Asn Lys Leu 
     530                535                540
Lys Phe Ser Ala Tyr Leu Glu Thr Glu Tyr Lys Val His Ile Asn Pro 
 545                550                555                560
Asn Ser Leu Phe Asp Val Gln Val Lys Arg Ile His Glu Tyr Lys Arg 
                 565                570                575
Gln Leu Leu Asn Cys Leu His Ile Ile Thr Leu Tyr Asn Arg Ile Lys 
             580                585                590
Arg Glu Pro Asn Arg Phe Met Val Pro Arg Thr Ile Met Ile Gly Gly 
         595                600                605
Lys Ala Ala Pro Gly Tyr His Met Ala Lys Met Ile Ile Lys Leu Ile 
     610                615                620
Thr Ala Ile Gly Asp Val Val Asn His Asp Pro Ala Val Gly Asp Arg 
 625                630                635                640
Phe Arg Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu Lys 
                 645                650                655
Val Ile Pro Ala Ala Asp Leu Ser Glu Gln Ile Ser Thr Ala Gly Thr 
             660                665                670
Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala Leu 
         675                680                685
Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu Ala 
     690                695                700
Gly Glu Asp Asn Phe Phe Ile Phe Gly Met Arg Val Glu Asp Val Glu 
 705                710                715                720
Arg Leu Asp Gln Arg Gly Tyr Asn Ala Gln Glu Tyr Tyr Asp Arg Ile 
                 725                730                735
Pro Glu Leu Arg Gln Ile Ile Glu Gln Leu Ser Ser Gly Phe Phe Ser 
             740                745                750
Pro Lys Gln Pro Asp Leu Phe Lys Asp Ile Val Asn Met Val Met His 
         755                760                765
His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Glu Tyr Ile Lys Cys 
     770                775                780
Gln Asp Lys Val Ser Glu Leu Tyr Lys Asn Pro Arg Glu Trp Thr Arg 
 785                790                795                800
Met Val Ile Arg Asn Ile Ala Thr Ser Gly Lys Phe Ser Ser Asp Arg 
                 805                810                815
Thr Ile Ala Gln Tyr Ala Arg Glu Ile Trp Gly Leu Glu Pro Ser Arg 
             820                825                830
Gln Arg Leu Pro Ala Pro Asp Glu Lys Ile 
         835                840



<210> 2860
<211> 2798
<212> DNA
<213> Rattus norvegicus
<308> L10669
<400> 2860

gtccaggcc  ctttcagac  aggataaga  aaagcaaat  agtgttcgt  gcctagccg  60
cgtggaaaa  gtgtctgac  tgaaaaaga  cttcaaccg  cacctacat  tcaccctgg  120
caaggatcg  aatgtggcc  ctccgagag  ttactattt  gcactggct  acaccgtgc  180
ggaccacct  gtggaccgc  ggatccgca  acagcagca  tactatgcg  aggacccca  240
gaggattta  tacctgtct  tggagttgt  catggggag  acactgcag  acaccatgg  300
gaacctggc  ttggagaat  cctgcgatg  ggccaccta  cagctgggt  tggacatgg  360
ggagctgga  gagatcgag  aggatgcag  gttgggcaa  ggaggcctg  gacgcctgg  420
agcttgctt  ctggactcc  tggctacac  ggggctagc  gcctatggc  acgggatcc  480
ctatgagtt  gggattttt  atcagaaga  ctgtggggg  tggcagatg  aagaagctg  540
tgactggct  cgctatggc  acccctggg  gaaggcccg  ccagagttc  cgctgcctg  600
gcacttcta  ggtcgagtg  agcacacca  tcagggtgc  aagtgggtg  acacacagg  660
agtgttggc  atgccctat  acactcctg  gcctggcta  cgaaacaac  ttgtcaaca  720
catgcgcct  tggtcggcc  aggcacctc  ttacttcaa  ctcaaggac  tcaacgttg  780
cggctacat  caggccgtg  tggaccgaa  cctggctga  aacatctca  gtgttttgt  840
ccccaatga  aagttcttt  aagggaagg  attgcggct  aagcaggag  actttgtgg  900
ggccgccac  ctccaggac  tcattcgcc  tttcaagtc  tccaagttt  gctgccgtg  960
tcctgtgcg  acaaacttt  atgctttcc  tgataaggt  gccatccag  tcaacgaca  1020
ccacccttc  ttggccatc  ctgaactta  taggattct  gtggacctg  aacgactgg  1080
ctgggacaa  gcctgggat  tgacagtga  gacctgtgc  tacaccaac  acacagtgc  1140
gcctgaagc  ctggagcgc  ggccagtgc  cctcatgga  acactgctt  cccgccatc  1200
gcagatcat  tatgagatc  accagcgtt  ccttaatcg  gtggcggcc  cattccctg  1260
ggacgtaga  aggctgcgg  gcatgtcac  cgtggagga  ggagcggtg  aacgcatca  1320
catggcaca  ttgtgcatt  ctggttccc  cgcagtcaa  ggtgtggct  gcatccatt  1380
ggagatcct  aagaaaacc  tcttcaagg  cttttatga  ctggagcct  acaagttcc  1440
gaacaagac  aatggcatc  cccctcggc  ctggttggt  ctgtgtaac  ctgggctgg  1500
agaggtcat  gctgagcgc  tcggtgagg  gtacatctc  gatcttgac  agctacgca  1560
gctgctctc  tatctggat  atcaagcct  tatccgtga  gtggccaaa  tcaaacagg  1620
aaacaagct  aaattctct  cctacctgg  gaccgaata  aaagtccac  tcaacccca  1680
ctccctctt  gacgtccag  tgaagagga  tcatgagta  aaacgccag  ttctcaatt  1740
ccttcacat  atcaccttg  ataaccgca  caaaaggga  cccaatagg  tcatggtgc  1800
aaggactat  atgattgga  gcaaggctg  acccgggta  cacatggct  agatgatca  1860
caagcttat  accgccatt  gggatgtgg  caaccacga  cctgcggtg  gagaccgct  1920
ccgagtgat  ttcctggag  actaccgag  ctcactggc  gagaaagtt  ttcccgctg  1980
tgacctctc  gagcagatc  ccaccgcgg  cactgaggc  tcaggcact  gcaacatga  2040
gttcatgct  aacggggct  tgaccatcg  caccatgga  ggtgccaac  tggagatgg  2100
agaggaggc  ggggaagat  acttcttca  cttcggcat  cgggtggag  acgtggaaa  2160
gctggacca  agagggtac  atgcccagg  atactacga  cggattcct  agcttcggc  2220
gatcatcga  cagttaagc  gtggcttct  ctcccctaa  cagcctgac  tgttcaagg  2280
catcgtcaa  atggtcatg  accatgacc  gttcaaagt  tttgcagat  atgaggaat  2340
cattaaatg  caggacaaa  tcagtgagt  gtacaagaa  ccaagagag  ggacacgga  2400
ggtgatcag  aacatagcc  cctctggca  gttttccag  gaccgtacc  ttgcccagt  2460
tgcccggga  atctggggt  ttgaacctt  tcgtcagcg  ctgccagcc  cagatgaga  2520
gatctgagc  tccacacca  accccatac  tgcctttga  tctgtttgc  attcccgga  2580
tcaggccca  tccaggggt  gggcccctg  aattacatc  gggcccccc  ttttggaag  2640
ctcttttac  agtctctag  tcctgatgc  agtgtgact  aagaccctg  cctcttctt  2700
tccctcaac  ccctacccc  tttatttat  tatggggtc  aaccaatgc  cccactccc  2760
caataaatc  actctccat  accttcctt  aaaaaaaa  2798



<210> 2861
<211> 842
<212> PRT
<213> Rattus norvegicus
<308> AAA41253
<400> 2861

Met Ser Arg Pro Leu Ser Asp Gln Asp Lys Arg Lys Gln Ile Ser Val 
  1               5                  10                  15
Arg Gly Leu Ala Gly Val Glu Asn Val Ser Asp Leu Lys Lys Asn Phe 
             20                  25                  30
Asn Arg His Leu His Phe Thr Leu Val Lys Asp Arg Asn Val Ala Thr 
         35                  40                  45
Pro Arg Asp Tyr Tyr Phe Ala Leu Ala His Thr Val Arg Asp His Leu 
     50                  55                  60
Val Asp Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Ala Lys Asp Pro 
 65                  70                  75                  80
Lys Arg Ile Tyr Tyr Leu Ser Leu Glu Leu Tyr Met Gly Arg Thr Leu 
                 85                  90                  95
Gln Asn Thr Met Val Asn Leu Ala Leu Glu Asn Ala Cys Asp Glu Ala 
             100                105                110
Thr Tyr Gln Leu Gly Leu Asp Met Glu Glu Leu Glu Glu Ile Glu Glu 
         115                120                125
Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe 
     130                135                140
Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile 
 145                150                155                160
Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile Cys Gly Gly Trp Gln 
                 165                170                175
Met Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys 
             180                185                190
Ala Arg Pro Glu Phe Thr Leu Pro Val His Phe Tyr Gly Arg Val Glu 
         195                200                205
His Thr Ser Gln Gly Ala Lys Trp Val Asp Thr Gln Val Val Leu Ala 
     210                215                220
Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Arg Asn Asn Val Val Asn 
 225                230                235                240
Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Pro Tyr Phe Asn Leu Lys 
                 245                250                255
Asp Phe Asn Val Gly Gly Tyr Ile Gln Ala Val Leu Asp Arg Asn Leu 
             260                265                270
Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Lys Phe Phe Glu 
         275                280                285
Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr 
     290                295                300
Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser Lys Phe Gly Cys Arg 
 305                310                315                320
Asp Pro Val Arg Thr Asn Phe Asp Ala Phe Pro Asp Lys Val Ala Ile 
                 325                330                335
Gln Leu Asn Asp Thr His Pro Ser Leu Ala Ile Pro Glu Leu Ile Arg 
             340                345                350
Ile Leu Val Asp Leu Glu Arg Leu Asp Trp Asp Lys Ala Trp Asp Val 
         355                360                365
Thr Val Lys Thr Cys Ala Tyr Thr Asn His Thr Val Leu Pro Glu Ala 
     370                375                380
Leu Glu Arg Trp Pro Val His Leu Met Glu Thr Leu Leu Pro Arg His 
 385                390                395                400
Leu Gln Ile Ile Tyr Glu Ile Asn Gln Arg Phe Leu Asn Arg Val Ala 
                 405                410                415
Ala Ala Phe Pro Gly Asp Val Asp Arg Leu Arg Arg Met Ser Leu Val 
             420                425                430
Glu Glu Gly Ala Val Lys Arg Ile Asn Met Ala His Leu Cys Ile Ala 
         435                440                445
Gly Ser His Ala Val Asn Gly Val Ala Arg Ile His Ser Glu Ile Leu 
     450                455                460
Lys Lys Thr Ile Phe Lys Asp Phe Tyr Glu Leu Glu Pro His Lys Phe 
 465                470                475                480
Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Val Leu Cys 
                 485                490                495
Asn Pro Gly Leu Ala Glu Val Ile Ala Glu Arg Ile Gly Glu Glu Tyr 
             500                505                510
Ile Ser Asp Leu Asp Gln Leu Arg Lys Leu Leu Ser Tyr Leu Asp Asp 
         515                520                525
Gln Ala Phe Ile Arg Asp Val Ala Lys Val Lys Gln Glu Asn Lys Leu 
     530                535                540
Lys Phe Ser Ala Tyr Leu Glu Thr Glu Tyr Lys Val His Ile Asn Pro 
 545                550                555                560
Asn Ser Leu Phe Asp Val Gln Val Lys Arg Ile His Glu Tyr Lys Arg 
                 565                570                575
Gln Leu Leu Asn Cys Leu His Ile Ile Thr Leu Tyr Asn Arg Ile Lys 
             580                585                590
Arg Glu Pro Asn Arg Phe Met Val Pro Arg Thr Ile Met Ile Gly Gly 
         595                600                605
Lys Ala Ala Pro Gly Tyr His Met Ala Lys Met Ile Ile Lys Leu Ile 
     610                615                620
Thr Ala Ile Gly Asp Val Val Asn His Asp Pro Ala Val Gly Asp Arg 
 625                630                635                640
Phe Arg Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu Lys 
                 645                650                655
Val Ile Pro Ala Ala Asp Leu Ser Glu Gln Ile Ser Thr Ala Gly Thr 
             660                665                670
Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala Leu 
         675                680                685
Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu Ala 
     690                695                700
Gly Glu Asp Asn Phe Phe Ile Phe Gly Met Arg Val Glu Asp Val Glu 
 705                710                715                720
Arg Leu Asp Gln Arg Gly Tyr Asn Ala Gln Glu Tyr Tyr Asp Arg Ile 
                 725                730                735
Pro Glu Leu Arg Gln Ile Ile Glu Gln Leu Ser Ser Gly Phe Phe Ser 
             740                745                750
Pro Lys Gln Pro Asp Leu Phe Lys Asp Ile Val Asn Met Val Met His 
         755                760                765
His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Glu Tyr Ile Lys Cys 
     770                775                780
Gln Asp Lys Val Ser Glu Leu Tyr Lys Asn Pro Arg Glu Trp Thr Arg 
 785                790                795                800
Met Val Ile Arg Asn Ile Ala Thr Ser Gly Lys Phe Ser Ser Asp Arg 
                 805                810                815
Thr Ile Ala Gln Tyr Ala Arg Glu Ile Trp Gly Leu Glu Pro Ser Arg 
             820                825                830
Gln Arg Leu Pro Ala Pro Asp Glu Lys Ile 
         835                840



<210> 2862
<211> 5822
<212> DNA
<213> Rattus norvegicus
<308> L11002
<400> 2862

ggtcctgtc  ctcagcacg  tcatgtgct  acacgctcg  acacccacc  tccccgtac  60
cacatacac  catagcctc  ctggcctcc  cccacgggg  aggaccact  gtagtattt  120
ccttggttt  gtggggtac  gtggatgtg  atactgtaa  tagcttgtg  tcagacacc  180
ctgcgtgga  gaggcgggt  caggactcg  accctcctc  caagactcc  tgggaagat  240
tccctctat  taactaacc  acggggaac  caggtctgg  aacggaggg  caccttggg  300
cacagaata  tggttgctt  aggggcaat  ccctctgtc  tggcctgga  tcagtgtta  360
tacatctga  caaacatct  cagaaataa  gtgagaata  ttctgccaa  aaaaaaaaa  420
aaaaaagcc  tttaagtat  ttaaagaat  ttttttctg  attgtcata  ctgatagat  480
ttttttcct  tttttttct  ttctttttt  ttttttttt  tacatgaac  ctcagagga  540
atggtgggc  tgagataat  aagccctgt  tatgttaca  agggctgga  agtggcaag  600
gggagcggc  aagagcagg  gccgccagg  atgattttg  ttcctcctg  ggtagggct  660
ctgtcttcg  tctgtagaa  gccagcact  ggggaagag  ggctagcta  ggttctact  720
aggctcgct  ttgctcttc  tatgcctag  gcctaagaa  gctagcttt  agcatcaac  780
tgtccctaa  taaggcacc  accagtgga  actccggac  agccaggag  ggttgactg  840
cttatgtgc  atttgggag  ctggagttt  cttgccctc  gccgctgcc  tcaaccgga  900
cagagcctc  gctggtgtt  cgaaaagca  gccgaatga  gcagagaag  tgagcactg  960
ctggaaagc  cacgaggaa  ggcgcaagg  atcgagagc  cgtgggctg  gcagtgcgg  1020
gcagggcct  gcgctgagg  tggccaggc  gcaggcgcc  ccctgggtc  acgtagccc  1080
catcctctt  ctcctcagc  tcggagggg  cattgagat  ccgatggat  caagcattc  1140
gaatgagct  acccaaccc  caacgatca  caagcagtc  gtgaaggac  acatcgtgg  1200
cccccgaga  aacatcctg  ttgaatgtg  agctaaagg  aaccccgcc  ccagtttcc  1260
ctggactcg  aacagcagg  tcttcaaca  tgccaagga  ccacgggtg  ccatgagga  1320
gaggtctgg  accttggtg  tcgacttcc  cagtggtgg  cggcctgag  agtacgaag  1380
ggagtacca  tgctttgcc  ggaacaaat  cggcacagc  cttagcaac  gcatccgcc  1440
gcaggtgtc  aaatctccc  tgtggccca  ggaaaacct  gaccccgtc  tggttcaag  1500
gggtgcccc  ttaaccctg  agtgcaacc  cccacctgg  ctcccatcc  ccgtcatct  1560
ctggatgag  agctccatg  agcccatca  ccaggacaa  cgtgtctcc  agggtcaca  1620
cggggacct  tacttctcc  acgtcatgc  gcaggacat  cagaccgac  acagctgca  1680
tgcacgctt  cacttcacc  acaccattc  gcagaagaa  cccttcacc  tcaaagtcc  1740
caccacccg  ggagttgcg  aaagaacac  tagcttcat  tatccccag  gcacgtcaa  1800
cagtcagat  gtactgcgc  gcatggacc  gctgctgga  tgcattgcc  ctggggtcc  1860
aacaccaga  attgcatgg  acaagaaag  tggggacct  ccatctgac  aggccaagt  1920
cgagaattt  aacaaggct  tgcgcatca  caatgtctc  gaagaggac  ctggggagt  1980
tttctgcct  gcctccaac  agatgggca  catccggca  acgatctcg  tgagagtaa  2040
ggctgcccc  tactggctg  atgagccca  gaacttgat  ctggctcct  gtgaagatg  2100
gaggctggt  tgtcgagcc  atgggaacc  gaagccgac  gtccagtgg  tggtgaatg  2160
agacccttt  caatcggca  cacccaacc  caaccgtga  gtggccgga  acactatca  2220
cttccggga  actcagatc  gcagcaggg  agtgtacca  tgtaacaca  ccaacgaac  2280
tggctacct  ctggccaat  ccttcgtca  cgtattaga  gtaccccct  ggatgctgt  2340
tccccggaa  cagctcatc  gggtgatcc  ttacaaccg  acgcgactg  actgtccgt  2400
ctttgggtc  cccattcca  cactccgat  gtttaagaa  gggcaagga  gcaacctgg  2460
tggtggtaa  taccacgtc  accaaaatg  cagcctgga  atcaagatg  ttcgcaaag  2520
ggaccaagg  atctacacc  gtgtggcca  caacatcct  ggaaaagct  aaaatcaag  2580
ccgcctgga  gtcaaagac  ccaccagga  ctacaggat  cctgaagac  aggtggcca  2640
gaggggcac  acagtgcag  tggagtgcc  tgtgaagca  gacccctcc  tgaaactca  2700
agtctcctg  ctgaaggat  acgagccac  ctacattgg  aacaggatg  aaaaggaag  2760
tgactccct  accatcttc  gagtggcag  gcgggacca  ggcagttac  cgtgcatgg  2820
cagcaccga  ctggaccag  acctggcaa  ggcctacct  actgttcta  ctgatcagg  2880
cactccgac  aaccgtttg  ctgccctgc  caaagggcg  ccagaccga  ccagggacc  2940
ggagctcac  gacctggcg  aaaggagtg  gaggctgac  tggatcccg  gggatgata  3000
caacagtcc  atcacagac  acgttgtcc  gtttgaaga  gaccagttc  agccaggag  3060
cttgcatga  cactccaag  tcccaggca  tgtcaactc  gccgtcctc  atctgtccc  3120
gtatgtcaa  tatgacttc  gagtcatcg  tgtcaacga  gttgggagc  gccacccca  3180
ccttccatc  gagcggtac  gaacaagcg  ggcaccccc  gaatccaac  ccagtgatg  3240
gaagggcga  gggacacga  aaaacaata  ggagatcac  tggacgcct  tgaatgcta  3300
ctccgcctt  ggccccaac  tgcgctact  cattgtcaa  tggcgacgg  gagaaaccc  3360
agagacttg  aacaatgtc  ccgtgtggg  ctctcgcta  gtggtgggg  agacccctg  3420
ctacgtacc  tatgagatc  gagtccagg  tgaaaatga  tttgggaaa  gcccggagc  3480
tgaaaccgt  attgggtac  cgggggaag  ttatcccag  gctgcaccc  ctgaagtta  3540
aatccgagt  ctgaacagc  cagccatca  ccttcagtg  aaccgcgtc  accctgaca  3600
ggtccaggg  cagctcaga  agtatcgag  ttactactg  agggaaagc  gtttgctga  3660
gaacctgtg  gtgtctcag  agagacagc  ggccagctt  cctggcgac  gcccccggg  3720
cgtggtggg  cgcctgttc  cctacagta  ctacaagct  gagatggtt  tggtcaatg  3780
gagaggtga  gggcctcga  gtgaaacca  ggaattcac  accccggaa  gagtaccca  3840
tgcccccag  cgtttcaga  tccgacagc  caacctgga  accatcaac  tggaatggg  3900
tcacccaga  caccccaac  ggatcctga  tggatacac  ctcagatac  tgcccttta  3960
tggaaccaa  ctgggaaag  agatggtgg  aaacttctc  cccaatcag  ccaagttct  4020
ggtgcagag  gcagacccc  tgtcccgtt  ccgcttctc  ctcagtgcc  ggacgcagg  4080
gggctctgg  gaagcagcc  cggaggagt  cccaacacc  ccaaatgaa  ctactccaa  4140
tgcagctcc  cccacattg  ccccgacta  cgtgggtac  acaggcctt  tgagcagta  4200
tgatgctac  gcccttgct  ccaccagtg  agccacaac  gttcccatc  tcccaacgg  4260
ggtacctac  accgtcgcc  ccaccattg  cacaactac  acaaccact  ccgccgcca  4320
caccactac  accacggag  gtcctccca  taccaccac  gggactaag  ttcacgaaa  4380
cgcccccga  gagcagtcc  tttggaacg  cacggtgct  cccaacagt  aatgggcca  4440
catcacctg  aagcacaat  tcaggcctg  aactgactt  gtggttgag  acatcgaca  4500
caaccatac  aaaaaaact  tccctgtta  ggcccaagc  cagcccata  agctgacag  4560
cctctttcc  gggatgacg  acacgttgc  ggtgtattc  cgggacaac  agggcatca  4620
cagtaccgt  atcaccttt  tgaccagta  agcttacac  aacaaccag  ctgacatcg  4680
cacccaggg  tggttcatc  ggctcatgt  tgccattgc  cttctggtg  tgatcctgc  4740
gatcgtctg  ttcatcaag  ggagtcgtg  cggcaagta  ccagtgcga  aaaagaagg  4800
tgtcccctt  ggccctgaa  accccaaag  agaagatgg  tcatttgac  acagtgacg  4860
ggacaacaa  cccctgcag  gcagccaga  atctctgga  ggcaccatc  agcaacagg  4920
gagtgacga  agcctagtg  actacggcg  gggtggcga  ggccagttc  acgaagatg  4980
ctcctttat  ggccagtac  ctgtcagaa  ggacaagga  gagaccgag  gcaatgaga  5040
ctcagaggc  acatctcca  tcaatgcca  ctattccct  gcctgatgg  gcatcccag  5100
cacagcact  ctttgcaag  aggagggga  aggggagag  aagccactg  agacctgcc  5160
ccaagccac  acaccttca  ggacaaggg  acaacatgg  ggtctgcca  gctgtgagg  5220
ccagtgacc  cccagctac  cacaccccc  cctagtgat  ccccattac  cttgggtgc  5280
attagatgg  aaagctgaa  ttaacgctc  ttggaggga  ccctagtcc  ttgccctgt  5340
tcacggcca  cctgagcgt  ccaccacaa  ggccaccct  gatctcggc  cacactcac  5400
tctttctat  gcttacaat  ttctcattc  tgttctctc  ctctctctc  ctctccctc  5460
ctctctctc  ctctgtgtg  gtgtctgtg  gtctgtgtg  ggcatatat  tgtgggggg  5520
tatgtatgt  tatatgtat  tgtatgtgt  tgtgtggta  atgtgtgag  tgtgtgtgt  5580
tttttgtat  gcgtatgca  ggggtatgc  tgtgcatgt  tatgtatgt  tctatgtat  5640
tgtgtgtgc  cgtgtgtgt  tgtgtgtat  tgtctgtgt  tctgtgtgt  tgtacatgt  5700
tgtctgtct  tgtgtctcc  tgtgtattt  tgtctgtgt  tctatgtgt  tctgtgtgc  5760
tgtctgtgt  tctctgtgc  attctgtct  tgtgtgtgt  tctgtctgt  tgtctgtct  5820
tc  5822



<210> 2863
<211> 1217
<212> PRT
<213> Rattus norvegicus
<308> AAB47753
<400> 2863

Ile Glu Ile Pro Met Asp Pro Ser Ile Gln Asn Glu Leu Thr Gln Pro 
  1               5                  10                  15
Pro Thr Ile Thr Lys Gln Ser Val Lys Asp His Ile Val Asp Pro Arg 
             20                  25                  30
Asp Asn Ile Leu Ile Glu Cys Glu Ala Lys Gly Asn Pro Ala Pro Ser 
         35                  40                  45
Phe His Trp Thr Arg Asn Ser Arg Phe Phe Asn Ile Ala Lys Asp Pro 
     50                  55                  60
Arg Val Ser Met Arg Arg Arg Ser Gly Thr Leu Val Ile Asp Phe Arg 
 65                  70                  75                  80
Ser Gly Gly Arg Pro Glu Glu Tyr Glu Gly Glu Tyr Gln Cys Phe Ala 
                 85                  90                  95
Arg Asn Lys Phe Gly Thr Ala Leu Ser Asn Arg Ile Arg Leu Gln Val 
             100                105                110
Ser Lys Ser Pro Leu Trp Pro Lys Glu Asn Leu Asp Pro Val Val Val 
         115                120                125
Gln Glu Gly Ala Pro Leu Thr Leu Gln Cys Asn Pro Pro Pro Gly Leu 
     130                135                140
Pro Ser Pro Val Ile Phe Trp Met Ser Ser Ser Met Glu Pro Ile Thr 
 145                150                155                160
Gln Asp Lys Arg Val Ser Gln Gly His Asn Gly Asp Leu Tyr Phe Ser 
                 165                170                175
Asn Val Met Leu Gln Asp Met Gln Thr Asp Tyr Ser Cys Asn Ala Arg 
             180                185                190
Phe His Phe Thr His Thr Ile Gln Gln Lys Asn Pro Phe Thr Leu Lys 
         195                200                205
Val Leu Thr Thr Arg Gly Val Ala Glu Arg Thr Pro Ser Phe Met Tyr 
     210                215                220
Pro Gln Gly Thr Ser Ser Ser Gln Met Val Leu Arg Gly Met Asp Leu 
 225                230                235                240
Leu Leu Glu Cys Ile Ala Ser Gly Val Pro Thr Pro Asp Ile Ala Trp 
                 245                250                255
Tyr Lys Lys Gly Gly Asp Leu Pro Ser Asp Lys Ala Lys Phe Glu Asn 
             260                265                270
Phe Asn Lys Ala Leu Arg Ile Thr Asn Val Ser Glu Glu Asp Ser Gly 
         275                280                285
Glu Tyr Phe Cys Leu Ala Ser Asn Lys Met Gly Ser Ile Arg His Thr 
     290                295                300
Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Leu Asp Glu Pro Lys 
 305                310                315                320
Asn Leu Ile Leu Ala Pro Gly Glu Asp Gly Arg Leu Val Cys Arg Ala 
                 325                330                335
Asn Gly Asn Pro Lys Pro Thr Val Gln Trp Leu Val Asn Gly Asp Pro 
             340                345                350
Leu Gln Ser Ala Pro Pro Asn Pro Asn Arg Glu Val Ala Gly Asp Thr 
         355                360                365
Ile Ile Phe Arg Asp Thr Gln Ile Ser Ser Arg Ala Val Tyr Gln Cys 
     370                375                380
Asn Thr Ser Asn Glu His Gly Tyr Leu Leu Ala Asn Ala Phe Val Ser 
 385                390                395                400
Val Leu Asp Val Pro Pro Arg Met Leu Ser Pro Arg Asn Gln Leu Ile 
                 405                410                415
Arg Val Ile Leu Tyr Asn Arg Thr Arg Leu Asp Cys Pro Phe Phe Gly 
             420                425                430
Ser Pro Ile Pro Thr Leu Arg Trp Phe Lys Asn Gly Gln Gly Ser Asn 
         435                440                445
Leu Asp Gly Gly Asn Tyr His Val Tyr Gln Asn Gly Ser Leu Glu Ile 
     450                455                460
Lys Met Ile Arg Lys Glu Asp Gln Gly Ile Tyr Thr Cys Val Ala Thr 
 465                470                475                480
Asn Ile Leu Gly Lys Ala Glu Asn Gln Val Arg Leu Glu Val Lys Asp 
                 485                490                495
Pro Thr Arg Ile Tyr Arg Met Pro Glu Asp Gln Val Ala Lys Arg Gly 
             500                505                510
Thr Thr Val Gln Leu Glu Cys Arg Val Lys His Asp Pro Ser Leu Lys 
         515                520                525
Leu Thr Val Ser Trp Leu Lys Asp Asp Glu Pro Leu Tyr Ile Gly Asn 
     530                535                540
Arg Met Lys Lys Glu Asp Asp Ser Leu Thr Ile Phe Gly Val Ala Glu 
 545                550                555                560
Arg Asp Gln Gly Ser Tyr Thr Cys Met Ala Ser Thr Glu Leu Asp Gln 
                 565                570                575
Asp Leu Ala Lys Ala Tyr Leu Thr Val Leu Ala Asp Gln Ala Thr Pro 
             580                585                590
Thr Asn Arg Leu Ala Ala Leu Pro Lys Gly Arg Pro Asp Arg Pro Arg 
         595                600                605
Asp Leu Glu Leu Thr Asp Leu Ala Glu Arg Ser Val Arg Leu Thr Trp 
     610                615                620
Ile Pro Gly Asp Asp Asn Asn Ser Pro Ile Thr Asp Tyr Val Val Gln 
 625                630                635                640
Phe Glu Glu Asp Gln Phe Gln Pro Gly Val Leu His Asp His Ser Lys 
                 645                650                655
Phe Pro Gly Ser Val Asn Ser Ala Val Leu His Leu Ser Pro Tyr Val 
             660                665                670
Asn Tyr Asp Phe Arg Val Ile Ala Val Asn Glu Val Gly Ser Ser His 
         675                680                685
Pro Ser Leu Pro Ser Glu Arg Tyr Arg Thr Ser Gly Ala Pro Pro Glu 
     690                695                700
Ser Asn Pro Ser Asp Val Lys Gly Glu Gly Thr Arg Lys Asn Asn Met 
 705                710                715                720
Glu Ile Thr Trp Thr Pro Met Asn Ala Thr Ser Ala Phe Gly Pro Asn 
                 725                730                735
Leu Arg Tyr Tyr Ile Val Lys Trp Arg Arg Arg Glu Thr Arg Glu Thr 
             740                745                750
Trp Asn Asn Val Thr Val Trp Gly Ser Arg Tyr Val Val Gly Gln Thr 
         755                760                765
Pro Val Tyr Val Pro Tyr Glu Ile Arg Val Gln Ala Glu Asn Asp Phe 
     770                775                780
Gly Lys Gly Pro Glu Pro Glu Thr Val Ile Gly Tyr Ser Gly Glu Asp 
 785                790                795                800
Leu Pro Ser Ala Pro Arg Arg Phe Arg Val Arg Gln Pro Asn Leu Glu 
                 805                810                815
Thr Ile Asn Leu Glu Trp Asp His Pro Glu His Pro Asn Gly Ile Leu 
             820                825                830
Ile Gly Tyr Thr Leu Arg Tyr Val Pro Phe Asn Gly Thr Lys Leu Gly 
         835                840                845
Lys Gln Met Val Glu Asn Phe Ser Pro Asn Gln Thr Lys Phe Ser Val 
     850                855                860
Gln Arg Ala Asp Pro Val Ser Arg Tyr Arg Phe Ser Leu Ser Ala Arg 
 865                870                875                880
Thr Gln Val Gly Ser Gly Glu Ala Ala Thr Glu Glu Ser Pro Thr Pro 
                 885                890                895
Pro Asn Glu Ala Thr Pro Thr Ala Ala Pro Pro Thr Leu Pro Pro Thr 
             900                905                910
Thr Val Gly Thr Thr Gly Leu Val Ser Ser Thr Asp Ala Thr Ala Leu 
         915                920                925
Ala Ala Thr Ser Glu Ala Thr Thr Val Pro Ile Ile Pro Thr Val Val 
     930                935                940
Pro Thr Thr Val Ala Thr Thr Ile Ala Thr Thr Thr Thr Thr Thr Ala 
 945                950                955                960
Ala Ala Thr Thr Thr Thr Thr Thr Glu Ser Pro Pro Thr Thr Thr Thr 
                 965                970                975
Gly Thr Lys Ile His Glu Thr Ala Pro Asp Glu Gln Ser Ile Trp Asn 
             980                985                990
Val Thr Val Leu Pro Asn Ser Lys Trp Ala Asn Ile Thr Trp Lys His 
         995                1000                1005
Asn Phe Arg Pro Gly Thr Asp Phe Val Val Glu Tyr Ile Asp Ser Asn 
     1010                1015                1020
His Thr Lys Lys Thr Val Pro Val Lys Ala Gln Ala Gln Pro Ile Gln 
 1025                1030                1035                1040
Leu Thr Asp Leu Phe Pro Gly Met Thr Tyr Thr Leu Arg Val Tyr Ser 
                 1045                1050                1055
Arg Asp Asn Glu Gly Ile Ser Ser Thr Val Ile Thr Phe Met Thr Ser 
             1060                1065                1070
Thr Ala Tyr Thr Asn Asn Gln Thr Asp Ile Ala Thr Gln Gly Trp Phe 
         1075                1080                1085
Ile Gly Leu Met Cys Ala Ile Ala Leu Leu Val Leu Ile Leu Leu Ile 
     1090                1095                1100
Val Cys Phe Ile Lys Arg Ser Arg Gly Gly Lys Tyr Pro Val Arg Glu 
 1105                1110                1115                1120
Lys Lys Asp Val Pro Leu Gly Pro Glu Asp Pro Lys Glu Glu Asp Gly 
                 1125                1130                1135
Ser Phe Asp Tyr Ser Asp Glu Asp Asn Lys Pro Leu Gln Gly Ser Gln 
             1140                1145                1150
Thr Ser Leu Asp Gly Thr Ile Lys Gln Gln Glu Ser Asp Asp Ser Leu 
         1155                1160                1165
Val Asp Tyr Gly Glu Gly Gly Glu Gly Gln Phe Asn Glu Asp Gly Ser 
     1170                1175                1180
Phe Ile Gly Gln Tyr Thr Val Arg Lys Asp Lys Glu Glu Thr Glu Gly 
 1185                1190                1195                1200
Asn Glu Ser Ser Glu Ala Thr Ser Pro Val Asn Ala Ile Tyr Ser Leu 
                 1205                1210                1215
Ala 
             1220



<210> 2864
<211> 4955
<212> DNA
<213> Homo sapiens
<308> AB018299
<400> 2864

ccaagcatt  agaatgagc  gacgcagcc  ccaaccatc  ccaagcagt  agcgaagga  60
cacatcgtg  acccccgtg  taacatcct  attgagtgt  aagcaaaag  gaaccctgc  120
cccagcttc  actggacac  aaacagcag  ttcttcaac  tcgccaagg  cccccgggt  180
tccatgagg  ggaggtctg  gaccctggt  attgacttc  gcagtggcg  gcggccgga  240
gaatatgag  gggaatatc  gtgcttcgc  cgcaacaaa  ttggcacgg  cctgtccaa  300
aggatccgc  tgcaggtgt  taaatctcc  ctgtggccc  aggaaaacc  agaccctgt  360
gtggtccaa  agggcgctc  tttgacgct  cagtgcaac  ccccgcctg  acttccatc  420
ccggtcatc  tctggatga  cagctccat  gagcccatc  cccaagaca  acgtgtctc  480
cagggccat  acggagacc  atacttctc  aacgtgatg  tgcaggaca  gcagaccga  540
tacagttgt  acgcccgct  ccacttcac  cacaccatc  agcagaaga  ccctttcac  600
ctcaaggtc  tcaccaccc  aggagttgc  gaaagaaca  caagcttca  gtatcccca  660
ggcaccgcg  gcagccaga  ggtgcttcg  ggcatggac  tcctgctgg  atgcatcgc  720
tccggggtc  caacaccag  catcgcatg  tacaagaaa  gtggggacc  cccatctga  780
aaggccaag  ttgagaact  taataaggc  ctgcgtatc  caaatgtct  tgaggaaga  840
tccggggag  atttctgcc  ggcctccaa  aagatgggc  gcatccggc  cacgatctc  900
gtgagagta  aggctgctc  ctactggct  gacgaaccc  agaacctta  tctggctcc  960
ggcgaggat  ggagactgg  gtgtcgagc  aatggaaac  ccaaaccca  tgtccagtg  1020
atggtgaat  gggaacctt  gcaatcggc  ccacctaac  caaaccgtg  ggtggccgg  1080
gacaccatc  tcttccggg  cacccagat  agcagcagg  ctgtgtacc  gtgcaacac  1140
tccaacgag  atggctacc  gctggccaa  gcctttgtc  gtgtgctgg  tgtgccgcc  1200
cggatgctg  cgccccgga  ccagctcat  cgagtgatt  tttacaacc  gacgcggct  1260
gactgccct  tctttgggt  tcccatccc  acactgcga  ggtttaaga  tgggcaagg  1320
agcaacctg  atggtggca  ctaccatgt  tatgagaac  gcagtctgg  aattaagat  1380
atccgcaaa  aggaccagg  catctacac  tgtgtcgcc  ccaacatcc  gggcaaagc  1440
gaaaaccaa  tccgcctgg  ggtcaaaga  cccaccagg  tctaccgga  gcccgagga  1500
caggtggcc  gaaggggca  cacggtgca  ctggagtgt  gggtgaagc  cgacccctc  1560
ctgaaactc  ccgtctcct  gctgaagga  gacgagccg  tctatattg  aaacaggat  1620
aagaaggaa  acgactccc  gaccatctt  ggggtggca  agcgggacc  gggcagtta  1680
acgtgtgtc  ccagcaccg  gctagacca  gacctggcc  aggcctacc  caccgtgct  1740
gctgatcag  ccactccaa  taaccgttt  gctgccctg  ccaaaggac  gccagaccg  1800
ccccgggac  tggagctga  cgacctggc  gagaggagc  tgcggctga  ctggatccc  1860
ggggatgct  acaacagcc  catcacaga  tacgtcgtc  agtttgaag  agaccagtt  1920
caacctggg  tctggcatg  ccatcccaa  taccccggc  gcgttaact  agccgtcct  1980
cggctgtcc  cgtatgtca  ctaccagtt  cgtgtcatt  ccatcaacg  ggttgggag  2040
agccacccc  gcctcccat  cgagcgcta  cgaaccagt  gagcacccc  cgagtccaa  2100
cctggtgac  tgaagggag  ggggaccag  aagaacaac  tggagatca  gtggacgcc  2160
atgaatgcc  cctcggcct  tggccccaa  ctgcgctac  ttgtcaagt  gaggcggag  2220
gagactcga  aggcctgga  caacgtcac  gtgtggggc  ctcgctacg  ggtggggca  2280
accccagtc  acgtgccct  tgagatccg  gtccaggct  aaaatgact  cgggaaggg  2340
cctgagcca  agtccgtca  cggttactc  ggagaagat  tacccagtg  ccctaggcg  2400
ttccgagtc  ggcagccca  cctggagac  atcaacctg  aatgggatc  tcctgagca  2460
ccaaatggg  tcatgattg  atacactct  aaatatgtg  cctttaacg  gaccaaagt  2520
ggaaagcag  tagtggaaa  cttctctcc  aatcagacc  agttcacgg  gcaaagaac  2580
gaccccgtg  cacgctacc  ctttaccct  agcgccagg  cgcaggtgg  ctctgggga  2640
gccgtcaca  aggagtcac  agcaccccc  aatgaagct  ctccaaccg  agcttacac  2700
aacaaccaa  cggacatcg  cacccaggg  tggttcatt  ggcttatgt  cgccatcgc  2760
ctcctggtg  tgatcctgc  catcgtctg  ttcatcaag  ggagtcgcg  cggcaagta  2820
ccagtacga  aaaagaagg  tgttcccct  ggccctgaa  accccaagg  agaggatgg  2880
tcatttgac  atagtgatg  ggacaacaa  cccctgcag  gcagtcaga  atctctgga  2940
ggcaccatc  agcagcagg  gagtgacga  agcctggtg  actatggcg  gggtggcga  3000
ggtcagttc  atgaagacg  ctccttcat  ggccagtac  cggtcaaaa  ggacaagga  3060
gaaacagag  gcaacgaaa  ctcagaggc  acgtcacct  tcaatgcta  ctactctct  3120
gcctaacgg  gcccaccca  gcacagcca  cactttgca  gtgggagga  gggagaagg  3180
gagacaaaa  cactgcaga  ctaccacga  gccaccacc  ccttcagta  caagggtac  3240
atatggggg  ctgccaagc  gtgaggacc  gtagccacc  agccaccca  aagccccct  3300
ccaatgacc  cccttcagc  ccgggtgcc  ccagtgtgg  agagctgga  ccgtggctg  3360
gctcagctg  agggagcct  gccccttgc  cggtctcgc  gccaccccg  gcgttccac  3420
acactgtcc  cccttggcc  cggcacacg  tcacctttt  tgttggtta  gggacttct  3480
attgtctta  tttcgcttt  tgcatcttc  cctccagac  caatgtctc  gttttcttt  3540
ccttttgaa  aagagtccc  ggaaaagaa  gaataagtg  attctcccc  aggagaatc  3600
tttttgcaa  gataggcaa  aaggattga  tccatacca  aacacgtag  caggctgta  3660
tattcaaac  acctctggg  caatgcatt  ccaaaggat  cctttctcg  catatgcct  3720
ccctggccc  cagcccctc  gcctcggcc  tgtcagttg  tgagctggg  ttggctcct  3780
tctggaaaa  gacagtatt  ttggcaggg  gaaggtgcg  aggcctcct  gctgctctc  3840
ggtttggtt  ggaggtgtg  ttacctctt  ctcctcatt  ctcccctgc  cttttctct  3900
gaatatcta  gatgtgagc  gcattgact  tgaagacgt  tgaggaaca  gagtgggca  3960
tgatagaaa  gacttcaac  ccagtgact  tgtacctcc  gcagaagaa  atcaggtgt  4020
tggtcttgg  ggcactgtg  tcacctcta  agagaagaa  aaggctggg  ttggacttc  4080
tgcctcctc  ctggtgaaa  ccaggatgt  gatagaggg  cacacccac  ctgtccaga  4140
tagagggca  ctgtccacg  ggccagggc  catgctgcc  ccctcgagg  gatggaacc  4200
tgtgatgca  aagctttgc  ggtgtgttt  gggcataag  cactgctcc  cttccatct  4260
tagcagata  catcttctc  gccaattct  taggacact  aggctcttg  ttgacatgg  4320
gtgtggatg  ggacttgcc  caagactga  caggtctgc  ctttcattg  ggtgtatac  4380
tatcagggg  ccctgaggt  gcaccgtac  cagtgttgt  atgccccca  ctagggagg  4440
ctcaatgct  tttgtatgc  ttatgcagc  ctgatctgt  cctggagtt  ccaggttcc  4500
agctccccc  ctgcaagcc  tgaagcctc  agcaacgtc  atctccagg  gagcagggc  4560
gcctatgca  gtgttccgg  aggaccaga  gtggccact  aacacacgt  ctcaccagt  4620
accccaaat  gagacactc  cagacctgc  gttctcaga  cgaaggtgc  gccttcatc  4680
tccccacct  atgcatttt  gaaaccaaa  gtacctagc  tcagagaca  agaaggaga  4740
ggggagatc  tgagtctaa  aggaaccct  tagctgttt  tgcagctga  gtcagtttc  4800
ggagggtga  gctgatccc  aggaatgga  cagctgcca  gggcacagc  tccgatttg  4860
gcctctccg  ctgccagcc  gggggcctg  gccagacca  ggctctgtc  ttccgtgac  4920
ttattaaag  aacatttgc  acatgttta  gccgc  4955



<210> 2865
<211> 836
<212> PRT
<213> Homo sapiens
<308> BAA34476
<400> 2865

His Asn Gly Asp Leu Tyr Phe Ser Asn Val Met Leu Gln Asp Met Gln 
  1               5                  10                  15
Thr Asp Tyr Ser Cys Asn Ala Arg Phe His Phe Thr His Thr Ile Gln 
             20                  25                  30
Gln Lys Asn Pro Phe Thr Leu Lys Val Leu Thr Thr Arg Gly Val Ala 
         35                  40                  45
Glu Arg Thr Pro Ser Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln 
     50                  55                  60
Met Val Leu Arg Gly Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly 
 65                  70                  75                  80
Val Pro Thr Pro Asp Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro 
                 85                  90                  95
Ser Asp Lys Ala Lys Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr 
             100                105                110
Asn Val Ser Glu Glu Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn 
         115                120                125
Lys Met Gly Ser Ile Arg His Thr Ile Ser Val Arg Val Lys Ala Ala 
     130                135                140
Pro Tyr Trp Leu Asp Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu 
 145                150                155                160
Asp Gly Arg Leu Val Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val 
                 165                170                175
Gln Trp Met Val Asn Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro 
             180                185                190
Asn Arg Glu Val Ala Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile 
         195                200                205
Ser Ser Arg Ala Val Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr 
     210                215                220
Leu Leu Ala Asn Ala Phe Val Ser Val Leu Asp Val Pro Pro Arg Met 
 225                230                235                240
Leu Ser Pro Arg Asn Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr 
                 245                250                255
Arg Leu Asp Cys Pro Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp 
             260                265                270
Phe Lys Asn Gly Gln Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val 
         275                280                285
Tyr Glu Asn Gly Ser Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln 
     290                295                300
Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn 
 305                310                315                320
Gln Val Arg Leu Glu Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro 
                 325                330                335
Glu Asp Gln Val Ala Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg 
             340                345                350
Val Lys His Asp Pro Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp 
         355                360                365
Asp Glu Pro Leu Tyr Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser 
     370                375                380
Leu Thr Ile Phe Gly Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys 
 385                390                395                400
Val Ala Ser Thr Glu Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr 
                 405                410                415
Val Leu Gly Arg Pro Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu 
             420                425                430
Ala Glu Arg Ser Val Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn 
         435                440                445
Ser Pro Ile Thr Asp Tyr Val Val Gln Phe Glu Glu Asp Gln Phe Gln 
     450                455                460
Pro Gly Val Trp His Asp His Ser Lys Tyr Pro Gly Ser Val Asn Ser 
 465                470                475                480
Ala Val Leu Arg Leu Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile 
                 485                490                495
Ala Ile Asn Glu Val Gly Ser Ser His Pro Ser Leu Pro Ser Glu Arg 
             500                505                510
Tyr Arg Thr Ser Gly Ala Pro Pro Glu Ser Asn Pro Gly Asp Val Lys 
         515                520                525
Gly Glu Gly Thr Arg Lys Asn Asn Met Glu Ile Thr Trp Thr Pro Met 
     530                535                540
Asn Ala Thr Ser Ala Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp 
 545                550                555                560
Arg Arg Arg Glu Thr Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly 
                 565                570                575
Ser Arg Tyr Val Val Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile 
             580                585                590
Arg Val Gln Ala Glu Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser 
         595                600                605
Val Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Arg Ala Ala Pro Thr Glu 
     610                615                620
Val Lys Val Arg Val Met Asn Ser Thr Ala Ile Ser Leu Gln Trp Asn 
 625                630                635                640
Arg Val Tyr Ser Asp Thr Val Gln Gly Gln Leu Arg Glu Tyr Arg Ala 
                 645                650                655
Tyr Tyr Trp Arg Glu Ser Ser Leu Leu Lys Asn Leu Trp Val Ser Gln 
             660                665                670
Lys Arg Gln Gln Ala Ser Phe Pro Gly Asp Arg Leu Arg Gly Val Val 
         675                680                685
Ser Arg Leu Phe Pro Tyr Ser Asn Tyr Lys Leu Glu Met Val Val Val 
     690                695                700
Asn Gly Arg Gly Asp Gly Pro Arg Ser Glu Thr Lys Glu Phe Thr Thr 
 705                710                715                720
Pro Glu Gly Val Pro Ser Ala Pro Arg Arg Phe Arg Val Arg Gln Pro 
                 725                730                735
Asn Leu Glu Thr Ile Asn Leu Glu Trp Asp His Pro Glu His Pro Asn 
             740                745                750
Gly Ile Met Ile Gly Tyr Thr Leu Lys Tyr Val Ala Phe Asn Gly Thr 
         755                760                765
Lys Val Gly Lys Gln Ile Val Glu Asn Phe Ser Pro Asn Gln Thr Lys 
     770                775                780
Phe Thr Val Gln Arg Thr Asp Pro Val Ser Arg Tyr Arg Phe Thr Leu 
 785                790                795                800
Ser Ala Arg Thr Gln Val Gly Ser Gly Glu Ala Val Thr Glu Glu Ser 
                 805                810                815
Pro Ala Pro Pro Asn Glu Gly Arg Cys Met Ala Ala Ala Pro Gly Val 
             820                825                830
Lys Gly Pro Ser 
         835



<210> 2866
<211> 400
<212> DNA
<213> Rattus norvegicus
<308> L11035
<400> 2866

ctggggacc  tgctgttgg  tctgtgcct  cggtcggag  gggtaagag  caacagaag  60
ctgataaag  agcaggtta  gcaaaactc  ccatcgctg  ttgttcaag  gggagggac  120
gctatactg  attgtgact  tgataatga  atgtttgac  attttgctt  gtacaaaaa  180
taccctgcc  acagcccca  attcctcat  tctgtacgt  cgaataagg  taagaatga  240
gacggaaga  tcacagttt  ccttaacaa  accggcaaa  acttctcat  gcacatcac  300
gcctcccag  ctgaggact  tgcagtgtt  ctctctgcg  caacagcaa  tggagacag  360
ctcaccctt  ggaaaggaa  tcagctgac  atccagccct  400



<210> 2867
<211> 387
<212> DNA
<213> Homo sapiens
<308> AF327018
<400> 2867

agcatgttt  attatttcc  atggtacaa  aaataccct  ctgaaggtc  tacattcct  60
atatctata  gttccatta  ggataaaaa  gaagatgga  gattcactg  tttcttaaa  120
aaaagtgcc  agcacctct  tctgcacat  gtgccctcc  agcctggag  ctctgcagt  180
tacttctgt  cagcaagca  ttatatggg  ggaggtgct  acggactca  ctttggcaa  240
gggactcat  taatcatcc  gccctatat  cagaaccct  accctgccg  gtaccagct  300
agagactct  aatccagtg  caagtctgt  tgcctattc  ccgattttg  ttctcaaac  360
aatgtgtca  aaagtaaga  ttctgat  387



<210> 2868
<211> 643
<212> DNA
<213> Rattus norvegicus
<308> L11319
<400> 2868

aaagggcag  ggttcctct  ggtgattgt  tcgcgccct  ttgctgcta  ttaccgcgt  60
ctccattcc  ccacatgct  tctctagac  ttctagatg  tgtacggcg  atgaacaag  120
ggcagctgt  ctaccaagt  ctaaatttt  gaatgattg  ctcctcggc  ctaatgatc  180
ggaaggggc  gatgttgat  accggaagt  agagtccaa  tgtagtggt  ctcagtggc  240
gcatggagc  tgcgtttca  agaggggat  tccttttcc  cacgaaccg  gttgaagat  300
ctatacgtg  gggggaaat  gttgttttc  ggatagaag  aagagagat  cccatagtg  360
atcgagtct  gaagatcca  gaaaagcaa  atgggcata  caagttttt  accaaagga  420
ataataatg  cgttgatga  cgaggcctc  ataaacaag  acaacactg  ctggagaag  480
aagatgttg  agggagagc  agagggttt  ttccgtaca  tggaatcgt  acgatcctc  540
tgaatgact  tcctaaatt  agttatgca  tactgtttc  gctgggttt  tttgtgctg  600
tccatcgtg  gtaagaagc  ggcctcgct  gtcctggga  gct  643



<210> 2869
<211> 179
<212> PRT
<213> Rattus norvegicus
<308> P42667
<400> 2869

Met Leu Ser Leu Asp Phe Leu Asp Asp Val Arg Arg Met Asn Lys Arg 
  1               5                  10                  15
Gln Leu Tyr Tyr Gln Val Leu Asn Phe Gly Met Ile Val Ser Ser Ala 
             20                  25                  30
Leu Met Ile Trp Lys Gly Leu Met Leu Ile Thr Gly Ser Glu Ser Pro 
         35                  40                  45
Ile Val Val Val Leu Ser Gly Ser Met Glu Pro Ala Phe His Arg Gly 
     50                  55                  60
Asp Leu Leu Phe Leu Thr Asn Arg Val Glu Asp Pro Ile Arg Val Gly 
 65                  70                  75                  80
Glu Ile Val Val Phe Arg Ile Glu Gly Arg Glu Ile Pro Ile Val His 
                 85                  90                  95
Arg Val Leu Lys Ile His Glu Lys Gln Asp Gly His Ile Lys Phe Leu 
             100                105                110
Thr Lys Gly Asp Asn Asn Ala Val Asp Asp Arg Gly Leu Tyr Lys Gln 
         115                120                125
Gly Gln His Trp Leu Glu Lys Lys Asp Val Val Gly Arg Ala Arg Gly 
     130                135                140
Phe Val Pro Tyr Ile Gly Ile Val Thr Ile Leu Met Asn Asp Tyr Pro 
 145                150                155                160
Lys Phe Ser Tyr Ala Val Leu Phe Leu Leu Gly Leu Phe Val Leu Val 
                 165                170                175
His Arg Glu 
             180



<210> 2870
<211> 504
<212> DNA
<213> Homo sapiens
<308> AF090315
<400> 2870

atgaacaag  ggcagctct  ttatcaagt  ctaaatttt  gaatgattg  ctcatcggc  60
ctaatgatc  ggaaggggt  aatggtaat  actggaagt  aaagtccga  tgtagtggt  120
ctcagtggc  gcatggaac  tgcatttca  agaggagat  ttctctttc  aacaaatcg  180
gttgaagat  ccatacgag  gggagaaat  gttgttttc  ggatagaag  aagagagat  240
cctatagtt  accgagtct  gaagattca  gaaaagcaa  atgggcata  caagttttt  300
accaaagga  ataataatg  ggttgatga  cgaggcctc  ataaacaag  acaacattg  360
ctagagaaa  aagatgttg  ggggagagc  aggggattt  ttccttata  tggaattgt  420
acgatcctc  tgaatgact  tcctaaatt  aggtatgca  ttctctttt  gctgggttt  480
ttcgtgctg  tccatcgtg  gtaa  504



<210> 2871
<211> 179
<212> PRT
<213> Homo sapiens
<308> P21378
<400> 2871

Met Leu Ser Leu Asp Phe Leu Asp Asp Val Arg Arg Met Asn Lys Arg 
  1               5                  10                  15
Gln Leu Tyr Tyr Gln Val Leu Asn Phe Gly Met Ile Val Ser Ser Ala 
             20                  25                  30
Leu Met Ile Trp Lys Gly Leu Met Val Ile Thr Gly Ser Glu Ser Pro 
         35                  40                  45
Ile Val Val Val Leu Ser Gly Ser Met Glu Pro Ala Phe His Arg Gly 
     50                  55                  60
Asp Leu Leu Phe Leu Thr Asn Arg Val Glu Asp Pro Ile Arg Val Gly 
 65                  70                  75                  80
Glu Ile Val Val Phe Arg Ile Glu Gly Arg Glu Ile Pro Ile Val His 
                 85                  90                  95
Arg Val Leu Lys Ile His Glu Lys Gln Asn Gly His Ile Lys Phe Leu 
             100                105                110
Thr Lys Gly Asp Asn Asn Ala Val Asp Asp Arg Gly Leu Tyr Lys Gln 
         115                120                125
Gly Gln His Trp Leu Glu Lys Lys Asp Val Val Gly Arg Ala Arg Gly 
     130                135                140
Phe Val Pro Tyr Ile Gly Ile Val Thr Ile Leu Met Asn Asp Tyr Pro 
 145                150                155                160
Lys Phe Lys Tyr Ala Val Leu Phe Leu Leu Gly Leu Phe Val Leu Val 
                 165                170                175
His Arg Glu 
             180



<210> 2872
<211> 643
<212> DNA
<213> Rattus norvegicus
<308> L11319
<400> 2872

aaagggcag  ggttcctct  ggtgattgt  tcgcgccct  ttgctgcta  ttaccgcgt  60
ctccattcc  ccacatgct  tctctagac  ttctagatg  tgtacggcg  atgaacaag  120
ggcagctgt  ctaccaagt  ctaaatttt  gaatgattg  ctcctcggc  ctaatgatc  180
ggaaggggc  gatgttgat  accggaagt  agagtccaa  tgtagtggt  ctcagtggc  240
gcatggagc  tgcgtttca  agaggggat  tccttttcc  cacgaaccg  gttgaagat  300
ctatacgtg  gggggaaat  gttgttttc  ggatagaag  aagagagat  cccatagtg  360
atcgagtct  gaagatcca  gaaaagcaa  atgggcata  caagttttt  accaaagga  420
ataataatg  cgttgatga  cgaggcctc  ataaacaag  acaacactg  ctggagaag  480
aagatgttg  agggagagc  agagggttt  ttccgtaca  tggaatcgt  acgatcctc  540
tgaatgact  tcctaaatt  agttatgca  tactgtttc  gctgggttt  tttgtgctg  600
tccatcgtg  gtaagaagc  ggcctcgct  gtcctggga  gct  643



<210> 2873
<211> 179
<212> PRT
<213> Rattus norvegicus
<308> P42667
<400> 2873

Met Leu Ser Leu Asp Phe Leu Asp Asp Val Arg Arg Met Asn Lys Arg 
  1               5                  10                  15
Gln Leu Tyr Tyr Gln Val Leu Asn Phe Gly Met Ile Val Ser Ser Ala 
             20                  25                  30
Leu Met Ile Trp Lys Gly Leu Met Leu Ile Thr Gly Ser Glu Ser Pro 
         35                  40                  45
Ile Val Val Val Leu Ser Gly Ser Met Glu Pro Ala Phe His Arg Gly 
     50                  55                  60
Asp Leu Leu Phe Leu Thr Asn Arg Val Glu Asp Pro Ile Arg Val Gly 
 65                  70                  75                  80
Glu Ile Val Val Phe Arg Ile Glu Gly Arg Glu Ile Pro Ile Val His 
                 85                  90                  95
Arg Val Leu Lys Ile His Glu Lys Gln Asp Gly His Ile Lys Phe Leu 
             100                105                110
Thr Lys Gly Asp Asn Asn Ala Val Asp Asp Arg Gly Leu Tyr Lys Gln 
         115                120                125
Gly Gln His Trp Leu Glu Lys Lys Asp Val Val Gly Arg Ala Arg Gly 
     130                135                140
Phe Val Pro Tyr Ile Gly Ile Val Thr Ile Leu Met Asn Asp Tyr Pro 
 145                150                155                160
Lys Phe Ser Tyr Ala Val Leu Phe Leu Leu Gly Leu Phe Val Leu Val 
                 165                170                175
His Arg Glu 
             180



<210> 2874
<211> 504
<212> DNA
<213> Homo sapiens
<308> AF090315
<400> 2874

atgaacaag  ggcagctct  ttatcaagt  ctaaatttt  gaatgattg  ctcatcggc  60
ctaatgatc  ggaaggggt  aatggtaat  actggaagt  aaagtccga  tgtagtggt  120
ctcagtggc  gcatggaac  tgcatttca  agaggagat  ttctctttc  aacaaatcg  180
gttgaagat  ccatacgag  gggagaaat  gttgttttc  ggatagaag  aagagagat  240
cctatagtt  accgagtct  gaagattca  gaaaagcaa  atgggcata  caagttttt  300
accaaagga  ataataatg  ggttgatga  cgaggcctc  ataaacaag  acaacattg  360
ctagagaaa  aagatgttg  ggggagagc  aggggattt  ttccttata  tggaattgt  420
acgatcctc  tgaatgact  tcctaaatt  aggtatgca  ttctctttt  gctgggttt  480
ttcgtgctg  tccatcgtg  gtaa  504



<210> 2875
<211> 179
<212> PRT
<213> Homo sapiens
<308> P21378
<400> 2875

Met Leu Ser Leu Asp Phe Leu Asp Asp Val Arg Arg Met Asn Lys Arg 
  1               5                  10                  15
Gln Leu Tyr Tyr Gln Val Leu Asn Phe Gly Met Ile Val Ser Ser Ala 
             20                  25                  30
Leu Met Ile Trp Lys Gly Leu Met Val Ile Thr Gly Ser Glu Ser Pro 
         35                  40                  45
Ile Val Val Val Leu Ser Gly Ser Met Glu Pro Ala Phe His Arg Gly 
     50                  55                  60
Asp Leu Leu Phe Leu Thr Asn Arg Val Glu Asp Pro Ile Arg Val Gly 
 65                  70                  75                  80
Glu Ile Val Val Phe Arg Ile Glu Gly Arg Glu Ile Pro Ile Val His 
                 85                  90                  95
Arg Val Leu Lys Ile His Glu Lys Gln Asn Gly His Ile Lys Phe Leu 
             100                105                110
Thr Lys Gly Asp Asn Asn Ala Val Asp Asp Arg Gly Leu Tyr Lys Gln 
         115                120                125
Gly Gln His Trp Leu Glu Lys Lys Asp Val Val Gly Arg Ala Arg Gly 
     130                135                140
Phe Val Pro Tyr Ile Gly Ile Val Thr Ile Leu Met Asn Asp Tyr Pro 
 145                150                155                160
Lys Phe Lys Tyr Ala Val Leu Phe Leu Leu Gly Leu Phe Val Leu Val 
                 165                170                175
His Arg Glu 
             180



<210> 2876
<211> 1842
<212> DNA
<213> Rattus norvegicus
<308> L11694
<400> 2876

cgccagagc  gcagcttct  tcgccccgc  gcccgtcgc  accatggtg  agatcgtga  60
agtgaagac  caggcatat  cggatcaga  gccgggcac  agcgggttg  ggaagcgag  120
gaaggtgtt  cagggcaac  ctaactatg  ggagaattt  atccaaagc  tcgtctcca  180
cgtggagcc  gcgttgagg  aggaggcta  cctggttgt  ggcggggac  gtcgcttct  240
catgaccga  gccatccag  tcatcgtac  catcgccgc  gccaacggg  ttggccgcc  300
ggttattgg  cagaatgga  tcctctcca  tcctgctgt  tcctgcatt  tccgaaaaa  360
caaagccat  ggtgggatc  ttctgacag  tagccacaa  ccaggaggg  ccaatggag  420
ttttggaat  aaattcaat  tttctaatg  gggtcctgc  ccagaagca  tcactgata  480
aattttcca  atcagcaag  caatcgaag  atatgccat  tgccctgac  tgaaggtag  540
cctcggtgt  ctggggaag  agcagtttg  cttggaaaa  aagttcaag  ccttcacag  600
ggagatcgt  gactcagtc  aggcctatg  cacaatgct  agaaacatc  ttgatttca  660
cgcactgaa  gagctactc  ctggcccaa  cagactgaa  atccgcatc  acgccatgc  720
cggagttgt  ggaccgtac  tcaagaaga  cctctgtga  gaacttggt  cccccgcaa  780
ctcagctgt  aactgtgtt  ccctggagg  ttttggagg  caccaccct  accccaacc  840
cacctacgc  gctgacctg  tggaaacca  gaagtcagg  gagcatgat  tcggggctg  900
ctttgatgg  gatggggat  ggaacatga  tctgggcaa  cacgggttc  ttgtgaacc  960
ttctgactc  gtggctgtc  ttgcagcca  catcttcag  attccgtat  tccagcaga  1020
tggggtccg  ggcttcgca  gcagcatgc  caccagtgg  gctctggac  gggtagcaa  1080
cgccacaaa  atcgcttcg  atgagaccc  aactggctg  aagtttttt  ggaatttga  1140
ggatgcaag  aagctttcc  tctgtggag  ggagagctt  gggactggt  cagaccaca  1200
ccgagagaa  gatggactg  gggctgtcc  ggcctggct  tccattctg  ccacccgca  1260
acagagggt  gaggacatt  tcaaagacc  ctggcagaa  tttggtcgg  acttcttca  1320
caggtatga  tacgaggag  tggaagccg  gggggcaaa  aaaatgatg  aggacctgg  1380
ggccctgat  ctggaccgc  cctttgtgg  gaagcagtt  tcagcaaac  ataaagtct  1440
cacggtgga  aaagctgat  acttcgaat  tagtgaccc  gtagatgga  gcatttcaa  1500
aaatcaggg  ttgcggctt  tttttgcag  tggttctcg  atcatcttc  gactgagcg  1560
caccgggag  gctggggct  ccatccggc  ctatattga  agctacgag  aggacgctg  1620
caagatcaa  caggacccc  aggtcatgc  ggcacccct  atctccatt  ctctgaaag  1680
gtcccagct  caggagagg  caggccgca  tgccccaac  gtcatcacc  agagagatg  1740
ctggatgtg  cacatcctc  ccaggaact  tccacactg  ctgattgaa  agcacagac  1800
gaacagtgt  ttcgacctg  cctttagac  catcttatt  ta  1842



<210> 2877
<211> 561
<212> PRT
<213> Rattus norvegicus
<308> P38652
<400> 2877

Val Lys Ile Val Thr Val Lys Thr Gln Ala Tyr Pro Asp Gln Lys Pro 
  1               5                  10                  15
Gly Thr Ser Gly Leu Arg Lys Arg Val Lys Val Phe Gln Gly Asn Ala 
             20                  25                  30
Asn Tyr Ala Glu Asn Phe Ile Gln Ser Ile Val Ser Thr Val Glu Pro 
         35                  40                  45
Ala Leu Arg Gln Glu Ala Thr Leu Val Val Gly Gly Asp Gly Arg Phe 
     50                  55                  60
Tyr Met Thr Glu Ala Ile Gln Leu Ile Val Arg Ile Ala Ala Ala Asn 
 65                  70                  75                  80
Gly Ile Gly Arg Leu Val Ile Gly Gln Asn Gly Ile Leu Ser Thr Pro 
                 85                  90                  95
Ala Val Ser Cys Ile Ile Arg Lys Ile Lys Ala Ile Gly Gly Ile Ile 
             100                105                110
Leu Thr Ala Ser His Asn Pro Gly Gly Pro Asn Gly Asp Phe Gly Ile 
         115                120                125
Lys Phe Asn Ile Ser Asn Gly Gly Pro Ala Pro Glu Ala Ile Thr Asp 
     130                135                140
Lys Ile Phe Gln Ile Ser Lys Thr Ile Glu Glu Tyr Ala Ile Cys Pro 
 145                150                155                160
Asp Leu Lys Val Asp Leu Gly Val Leu Gly Lys Gln Gln Phe Asp Leu 
                 165                170                175
Glu Asn Lys Phe Lys Pro Phe Thr Val Glu Ile Val Asp Ser Val Glu 
             180                185                190
Ala Tyr Ala Thr Met Leu Arg Asn Ile Phe Asp Phe Asn Ala Leu Lys 
         195                200                205
Glu Leu Leu Ser Gly Pro Asn Arg Leu Lys Ile Arg Ile Asp Ala Met 
     210                215                220
His Gly Val Val Gly Pro Tyr Val Lys Lys Ile Leu Cys Glu Glu Leu 
 225                230                235                240
Gly Ala Pro Ala Asn Ser Ala Val Asn Cys Val Pro Leu Glu Asp Phe 
                 245                250                255
Gly Gly His His Pro Asp Pro Asn Leu Thr Tyr Ala Ala Asp Leu Val 
             260                265                270
Glu Thr Met Lys Ser Gly Glu His Asp Phe Gly Ala Ala Phe Asp Gly 
         275                280                285
Asp Gly Asp Arg Asn Met Ile Leu Gly Lys His Gly Phe Phe Val Asn 
     290                295                300
Pro Ser Asp Ser Val Ala Val Ile Ala Ala Asn Ile Phe Ser Ile Pro 
 305                310                315                320
Tyr Phe Gln Gln Thr Gly Val Arg Gly Phe Ala Arg Ser Met Pro Thr 
                 325                330                335
Ser Gly Ala Leu Asp Arg Val Ala Asn Ala Thr Lys Ile Ala Ser Tyr 
             340                345                350
Glu Thr Pro Thr Gly Trp Lys Phe Phe Gly Asn Leu Met Asp Ala Ser 
         355                360                365
Lys Leu Ser Leu Cys Gly Glu Glu Ser Phe Gly Thr Gly Ser Asp His 
     370                375                380
Ile Arg Glu Lys Asp Gly Leu Trp Ala Val Leu Ala Trp Leu Ser Ile 
 385                390                395                400
Leu Ala Thr Arg Lys Gln Arg Val Glu Asp Ile Leu Lys Asp His Trp 
                 405                410                415
Gln Lys Phe Gly Arg Asn Phe Phe Thr Arg Tyr Asp Tyr Glu Glu Val 
             420                425                430
Glu Ala Glu Gly Ala Asn Lys Met Met Lys Asp Leu Glu Ala Leu Met 
         435                440                445
Leu Asp Arg Ser Phe Val Gly Lys Gln Phe Ser Ala Asn Asp Lys Val 
     450                455                460
Tyr Thr Val Glu Lys Ala Asp Asn Phe Glu Tyr Ser Asp Pro Val Asp 
 465                470                475                480
Gly Ser Ile Ser Lys Asn Gln Gly Leu Arg Leu Ile Phe Ala Asp Gly 
                 485                490                495
Ser Arg Ile Ile Phe Arg Leu Ser Gly Thr Gly Ser Ala Gly Ala Thr 
             500                505                510
Ile Arg Leu Tyr Ile Asp Ser Tyr Glu Lys Asp Ala Ala Lys Ile Asn 
         515                520                525
Gln Asp Pro Gln Val Met Leu Ala Pro Leu Ile Ser Ile Ala Leu Lys 
     530                535                540
Val Ser Gln Leu Gln Glu Arg Thr Gly Arg Thr Ala Pro Thr Val Ile 
 545                550                555                560
Thr 
                 565



<210> 2878
<211> 2487
<212> DNA
<213> Homo sapiens
<308> BC019920
<400> 2878

cctttcccc  cccgccgga  ctgccagga  gtgggctgg  gcggaggga  ggccctgtc  60
cctgtccct  taaggagga  ggccaaacg  cggcctaga  tgcggcgta  cccccaccc  120
ccgtgccct  accccagag  agctgcagc  tcagccggc  gcccctccg  cagccaagt  180
cgccgctct  acccccggc  gcaagtcgc  accatggtg  agatcgtga  agttaagac  240
caggcgtac  aggaccaga  gccgggcac  agcgggctg  ggaagcggg  gaaggtgtt  300
cagagcagc  ccaactacg  ggagaactt  atccagagt  tcatctcca  cgtggagcc  360
gcgcagcgg  aggaggcca  gctggtggt  ggcggggac  gccggttct  catgaagga  420
gccatccag  tcatcgctc  catcgctgc  gccaacggg  tcggtcgct  ggttatcgg  480
cagaatgga  tcctctcca  ccctgctgt  tcctgcatc  ttagaaaaa  caaagccat  540
ggtgggatc  ttctgacag  cagtcacaa  ccagggggc  ccaatggag  ttttggaat  600
aaattcaat  tttctaatg  aggtcctgc  ccagaagca  taactgata  aattttcca  660
atcagcaag  caattgaag  atatgcagt  tgccctgac  tgaaagtag  ccttggtgt  720
ctgggaaag  agcagtttg  cttggaaaa  aagttcaaa  ccttcacag  ggaaattgt  780
gattcggta  aagcttatg  tacaatgct  agaagcatc  ttgatttca  tgcactgaa  840
gaactactt  ctgggccaa  ccgactgaa  atccgtatt  atgctatgc  tggagttgt  900
ggaccgtat  taaagaaga  cctctgtga  gaactcggt  cccctgcga  ctcggcagt  960
aactgcgtt  ctctggagg  ctttggagg  caccaccct  accccaacc  cacctatgc  1020
gctgacctg  tggagacca  gaagtcagg  gagcatgat  ttggggctg  ctttgatgg  1080
gatggggat  gaaacatga  tctgggcaa  catgggttc  ttgtgaacc  ttcagactc  1140
gtggctgtc  ttgctgcca  catcttcag  attccgtat  tccagcaga  tggggtccg  1200
ggctttgca  ggagcatgc  cacgagtgg  gctctggac  gggtggcta  tgctacaaa  1260
attgctttg  atgagaccc  aactggctg  aagtttttt  ggaatttga  ggacgcgag  1320
aaactgtcc  tttgtgggg  ggagagctt  gggaccggt  ctgaccaca  ccgtgagaa  1380
gatggactg  gggctgtcc  tgcctggct  tccatccta  ccacccgca  gcagagtgt  1440
gaggacatt  tcaaagatc  ttggcaaaa  tatggccgg  atttcttca  caggtatga  1500
tacgaggag  tggaagctg  gggcgcaaa  aaaatgatg  aggacttgg  ggccctgat  1560
tttgatcgc  cctttgtgg  gaagcagtt  tcagcaaat  acaaagttt  cactgtgga  1620
aaggccgat  actttgaat  cagcgaccc  gtggatgga  gcatttcaa  aaatcaggg  1680
ttgcgcctc  ttttcacag  tggttctcg  atcgtcttc  gactgagcg  cactgggag  1740
gccggggcc  ccattcggc  gtacatcga  agctatgag  aggacgttg  caagattaa  1800
caggacccc  aggtcatgt  ggcccccct  atttccatt  ctctgaaag  gtcccagct  1860
caggagagg  cgggacgca  tgcacccac  gtcatcacc  aagaagaca  gcctgatgt  1920
gtacgtccc  ccacccccg  acccatcca  gtcatctga  tgaagagca  gacagaaac  1980
aaatgtatt  accaagcat  ttaggattt  actttttca  taaccagtt  acgagcagt  2040
catttacaa  gcactgcca  acaagatgc  cttgggagc  gtgagggaa  gaggacctg  2100
gggcttaga  caatctcaa  tccttttca  gccctcctg  attgctgct  cgtgggtat  2160
tgtctcctt  gccatcagg  acagtttac  ctacaatgt  agctatagg  ggagcatca  2220
cagtgagtg  ggccattct  catccttag  atgtggcaa  gaaatgatg  tgcaagttc  2280
tttctcttt  gtgaatctt  ccccccatt  cctgtttac  tgtaaccca  caaaatgca  2340
tttctagtg  cttctgtcc  atcagttct  tcctctgag  gagacgtac  tggctacag  2400
tttctgcct  gttttgcga  attgtccca  tcacacaga  attttggga  aataaagga  2460
aataagcta  aaaaaaaaa  aaaaaaa  2487



<210> 2879
<211> 561
<212> PRT
<213> Homo sapiens
<308> P36871
<400> 2879

Val Lys Ile Val Thr Val Lys Thr Gln Ala Tyr Gln Asp Gln Lys Pro 
  1               5                  10                  15
Gly Thr Ser Gly Leu Arg Lys Arg Val Lys Val Phe Gln Ser Ser Ala 
             20                  25                  30
Asn Tyr Ala Glu Asn Phe Ile Gln Ser Ile Ile Ser Thr Val Glu Pro 
         35                  40                  45
Ala Gln Arg Gln Glu Ala Thr Leu Val Val Gly Gly Asp Gly Arg Phe 
     50                  55                  60
Tyr Met Lys Glu Ala Ile Gln Leu Ile Ala Arg Ile Ala Ala Ala Asn 
 65                  70                  75                  80
Gly Ile Gly Arg Leu Val Ile Gly Gln Asn Gly Ile Leu Ser Thr Pro 
                 85                  90                  95
Ala Val Ser Cys Ile Ile Arg Lys Ile Lys Ala Ile Gly Gly Ile Ile 
             100                105                110
Leu Thr Ala Ser His Asn Pro Gly Gly Pro Asn Gly Asp Phe Gly Ile 
         115                120                125
Lys Phe Asn Ile Ser Asn Gly Gly Pro Ala Pro Glu Ala Ile Thr Asp 
     130                135                140
Lys Ile Phe Gln Ile Ser Lys Thr Ile Glu Glu Tyr Ala Val Cys Pro 
 145                150                155                160
Asp Leu Lys Val Asp Leu Gly Val Leu Gly Lys Gln Gln Phe Asp Leu 
                 165                170                175
Glu Asn Lys Phe Lys Pro Phe Thr Val Glu Ile Val Asp Ser Val Glu 
             180                185                190
Ala Tyr Ala Thr Met Leu Arg Ser Ile Phe Asp Phe Ser Ala Leu Lys 
         195                200                205
Glu Leu Leu Ser Gly Pro Asn Arg Leu Lys Ile Arg Ile Asp Ala Met 
     210                215                220
His Gly Val Val Gly Pro Tyr Val Lys Lys Ile Leu Cys Glu Glu Leu 
 225                230                235                240
Gly Ala Pro Ala Asn Ser Ala Val Asn Cys Val Pro Leu Glu Asp Phe 
                 245                250                255
Gly Gly His His Pro Asp Pro Asn Leu Thr Tyr Ala Ala Asp Leu Val 
             260                265                270
Glu Thr Met Lys Ser Gly Glu His Asp Phe Gly Ala Ala Phe Asp Gly 
         275                280                285
Asp Gly Asp Arg Asn Met Ile Leu Gly Lys His Gly Phe Phe Val Asn 
     290                295                300
Pro Ser Asp Ser Val Ala Val Ile Ala Ala Asn Ile Phe Ser Ile Pro 
 305                310                315                320
Tyr Phe Gln Gln Thr Gly Val Arg Gly Phe Ala Arg Ser Met Pro Thr 
                 325                330                335
Ser Gly Ala Leu Asp Arg Val Ala Ser Ala Thr Lys Ile Ala Leu Tyr 
             340                345                350
Glu Thr Pro Thr Gly Trp Lys Phe Phe Gly Asn Leu Met Asp Ala Ser 
         355                360                365
Lys Leu Ser Leu Cys Gly Glu Glu Ser Phe Gly Thr Gly Ser Asp His 
     370                375                380
Ile Arg Glu Lys Asp Gly Leu Trp Ala Val Leu Ala Trp Leu Ser Ile 
 385                390                395                400
Leu Ala Thr Arg Lys Gln Ser Val Glu Asp Ile Leu Lys Asp His Trp 
                 405                410                415
Gln Lys Tyr Gly Arg Asn Phe Phe Thr Arg Tyr Asp Tyr Glu Glu Val 
             420                425                430
Glu Ala Glu Gly Ala Asn Lys Met Met Lys Asp Leu Glu Ala Leu Met 
         435                440                445
Phe Asp Arg Ser Phe Val Gly Lys Gln Phe Ser Ala Asn Asp Lys Val 
     450                455                460
Tyr Thr Val Glu Lys Ala Asp Asn Phe Glu Tyr Ser Asp Pro Val Asp 
 465                470                475                480
Gly Ser Ile Ser Arg Asn Gln Gly Leu Arg Leu Ile Phe Thr Asp Gly 
                 485                490                495
Ser Arg Ile Val Phe Arg Leu Ser Gly Thr Gly Ser Ala Gly Ala Thr 
             500                505                510
Ile Arg Leu Tyr Ile Asp Ser Tyr Glu Lys Asp Val Ala Lys Ile Asn 
         515                520                525
Gln Asp Pro Gln Val Met Leu Ala Pro Leu Ile Ser Ile Ala Leu Lys 
     530                535                540
Val Ser Gln Leu Gln Glu Arg Thr Gly Arg Thr Ala Pro Thr Val Ile 
 545                550                555                560
Thr 
                 565



<210> 2880
<211> 1460
<212> DNA
<213> Rattus norvegicus
<308> L11930
<400> 2880

gtccgaagc  ggtggaaca  tatggctga  atgcaaaat  ttgtagaaa  attggagag  60
gcagtgggc  gcctggagg  ggtgtcaca  acttctgac  tgcactgtg  atatggaga  120
agtccttca  aaggagcag  tccatatgt  caagcattt  actcgctgc  tgccaatcc  180
gtggcggag  acttgaaga  gagtaagga  attggggga  atgtgcaga  acacgcgga  240
atggtccac  caggcctga  gttggagcg  gctctcctg  ttacagctt  tcagtgcca  300
cagccagcc  gtaataaac  ctcggattt  ttggcccct  tctcggagc  gatccagga  360
gttataacc  tccgggaga  gaaccgagg  agcaagttt  tcaatcatc  atcagctgt  420
agtgaaagc  tccaggccc  gggctgggt  gctctggct  cgaaacccg  cccctttgt  480
aaagagatg  atgatgccg  catgtttta  acaaaccga  tcctcaagg  gtacagaga  540
gtggataaa  agcatgtgg  ctgggttag  gcttacttg  gtatatgga  agaactgca  600
gcttacatc  aggagttcc  taccactgg  ctggcctgg  gcaagacgg  gcctgtggc  660
aaagaactg  gtggattgc  atctggacc  tctgtggga  caggcccac  tcctccccc  720
ccaggccct  ctcctcccc  agttcctac  agttctggc  ctgacgact  tgcttcacg  780
tcagcactg  ttgcacaga  taatcaggg  gaaagcatc  cacatgccc  gaaacatgt  840
tctgatgac  tgaagactc  caagaaccc  gccctgaaa  ctcagagtg  tccagttcg  900
agtggcccc  aaccattct  tgcacctaa  ccccaaact  gcccctccc  caaaccagc  960
acaaagaag  agccagctc  gctggaact  gaaggcaag  aatggagag  ggaaaacca  1020
gagaatgtt  ccaacctgg  gatcgatga  actgagctg  agcaggtgg  ttacatcta  1080
aagtgtgtc  acacgacat  gcaaatcaa  ggcaaaatc  attccatta  agtagataa  1140
tgtaagaag  ttggcctgg  gtttgatga  gtggtgggc  ttggtgaga  aatcaatag  1200
agggatgtc  aagttcagg  gatgggaaa  gtgccaacc  tttccatta  caaaacaga  1260
ggctgccac  cttacctga  taagaactc  ctggactgc  agatagtca  tgccaaatc  1320
tctgagatg  acgtcctca  tcctacaga  ggcggtgat  ttaacgagt  cccagtccc  1380
gagcagttc  agaccttgt  gaacggaca  aagttggtc  ccacagtga  agaaatcgc  1440
ggataagtg  attgcatggg  1460



<210> 2881
<211> 474
<212> PRT
<213> Rattus norvegicus
<308> Q08163
<400> 2881

Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
  1               5                  10                  15
Arg Leu Glu Ala Val Ser His Thr Ser Asp Met His Cys Gly Tyr Gly 
             20                  25                  30
Asp Ser Pro Ser Lys Gly Ala Val Pro Tyr Val Gln Ala Phe Asp Ser 
         35                  40                  45
Leu Leu Ala Asn Pro Val Ala Glu Tyr Leu Lys Met Ser Lys Glu Ile 
     50                  55                  60
Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Thr Gly Leu Lys 
 65                  70                  75                  80
Leu Glu Arg Ala Leu Leu Val Thr Ala Ser Gln Cys Gln Gln Pro Ala 
                 85                  90                  95
Gly Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile Gln 
             100                105                110
Glu Val Ile Thr Phe Arg Glu Lys Asn Arg Gly Ser Lys Phe Phe Asn 
         115                120                125
His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val Ala 
     130                135                140
Leu Ala Ala Lys Pro Gly Pro Phe Val Lys Glu Met Asn Asp Ala Ala 
 145                150                155                160
Met Phe Tyr Thr Asn Arg Val Leu Lys Glu Tyr Arg Asp Val Asp Lys 
                 165                170                175
Lys His Val Asp Trp Val Arg Ala Tyr Leu Ser Ile Trp Thr Glu Leu 
             180                185                190
Gln Ala Tyr Ile Lys Glu Phe His Thr Thr Gly Leu Ala Trp Ser Lys 
         195                200                205
Thr Gly Pro Val Ala Lys Glu Leu Ser Gly Leu Pro Ser Gly Pro Ser 
     210                215                220
Val Gly Ser Gly Pro Pro Pro Pro Pro Pro Gly Pro Pro Pro Pro Pro 
 225                230                235                240
Val Pro Thr Ser Ser Gly Ser Asp Asp Ser Ala Ser Arg Ser Ala Leu 
                 245                250                255
Phe Ala Gln Ile Asn Gln Gly Glu Ser Ile Thr His Ala Leu Lys His 
             260                265                270
Val Ser Asp Asp Met Lys Thr His Lys Asn Pro Ala Leu Lys Ala Gln 
         275                280                285
Ser Gly Pro Val Arg Ser Gly Pro Lys Pro Phe Ser Ala Pro Lys Pro 
     290                295                300
Gln Thr Ser Pro Ser Pro Lys Pro Ala Thr Lys Lys Glu Pro Ala Leu 
 305                310                315                320
Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Asn Gln Glu Asn Val 
                 325                330                335
Ser Asn Leu Val Ile Asp Asp Thr Glu Leu Lys Gln Val Ala Tyr Ile 
             340                345                350
Tyr Lys Cys Val Asn Thr Thr Leu Gln Ile Lys Gly Lys Ile Asn Ser 
         355                360                365
Ile Thr Val Asp Asn Cys Lys Lys Leu Gly Leu Val Phe Asp Asp Val 
     370                375                380
Val Gly Ile Gly Glu Ile Ile Asn Ser Arg Asp Val Lys Val Gln Val 
 385                390                395                400
Met Gly Lys Val Pro Thr Ile Ser Ile Asn Lys Thr Asp Gly Cys His 
                 405                410                415
Ala Tyr Leu Ser Lys Asn Ser Leu Asp Cys Glu Ile Val Ser Ala Lys 
             420                425                430
Ser Ser Glu Met Asn Val Leu Ile Pro Thr Glu Gly Gly Asp Phe Asn 
         435                440                445
Glu Phe Pro Val Pro Glu Gln Phe Lys Thr Leu Trp Asn Gly Gln Lys 
     450                455                460
Leu Val Thr Thr Val Thr Glu Ile Ala Gly 
 465                470



<210> 2883
<211> 475
<212> PRT
<213> Homo sapiens
<308> Q01518
<400> 2883

Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
  1               5                  10                  15
Arg Leu Glu Ala Val Ser His Thr Ser Asp Met His Arg Gly Tyr Ala 
             20                  25                  30
Asp Ser Pro Ser Lys Ala Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp 
         35                  40                  45
Ser Leu Leu Ala Gly Pro Val Ala Glu Tyr Leu Lys Ile Ser Lys Glu 
     50                  55                  60
Ile Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Thr Gly Leu 
 65                  70                  75                  80
Lys Leu Glu Arg Ala Leu Leu Val Thr Ala Ser Gln Cys Gln Gln Pro 
                 85                  90                  95
Ala Glu Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile 
             100                105                110
Lys Glu Val Ile Thr Phe Arg Glu Lys Asn Arg Gly Ser Lys Leu Phe 
         115                120                125
Asn His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val 
     130                135                140
Ala Met Ala Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn Asp Ala 
 145                150                155                160
Ala Met Phe Tyr Thr Asn Arg Val Leu Lys Glu Tyr Lys Asp Val Asp 
                 165                170                175
Lys Lys His Val Asp Trp Val Lys Ala Tyr Leu Ser Ile Trp Thr Glu 
             180                185                190
Leu Gln Ala Tyr Ile Lys Glu Phe His Thr Thr Gly Leu Ala Trp Ser 
         195                200                205
Lys Thr Gly Pro Val Ala Lys Glu Leu Ser Gly Leu Pro Ser Gly Pro 
     210                215                220
Ser Ala Gly Ser Gly Pro Pro Pro Pro Pro Pro Gly Pro Pro Pro Pro 
 225                230                235                240
Pro Val Ser Thr Ser Ser Gly Ser Asp Glu Ser Ala Ser Arg Ser Ala 
                 245                250                255
Leu Phe Ala Gln Ile Asn Gln Gly Glu Ser Ile Thr His Ala Leu Lys 
             260                265                270
His Val Ser Asp Asp Met Lys Thr His Lys Asn Pro Ala Leu Lys Ala 
         275                280                285
Gln Ser Gly Pro Val Arg Ser Gly Pro Lys Pro Phe Ser Ala Pro Lys 
     290                295                300
Pro Gln Thr Ser Pro Ser Pro Lys Arg Ala Thr Lys Lys Glu Pro Ala 
 305                310                315                320
Val Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Asn Gln Glu Asn 
                 325                330                335
Val Ser Asn Leu Val Ile Glu Asp Thr Glu Leu Lys Gln Val Ala Tyr 
             340                345                350
Ile Tyr Lys Cys Val Asn Thr Thr Leu Gln Ile Lys Gly Lys Ile Asn 
         355                360                365
Ser Ile Thr Val Asp Asn Cys Lys Lys Leu Gly Leu Val Phe Asp Asp 
     370                375                380
Val Val Gly Ile Val Glu Ile Ile Asn Ser Lys Asp Val Lys Val Gln 
 385                390                395                400
Val Met Gly Lys Val Pro Thr Ile Ser Ile Asn Lys Thr Asp Gly Cys 
                 405                410                415
His Ala Tyr Leu Ser Lys Asn Ser Leu Asp Cys Glu Ile Val Ser Ala 
             420                425                430
Lys Ser Ser Glu Met Asn Val Leu Ile Pro Thr Glu Gly Gly Asp Phe 
         435                440                445
Asn Glu Phe Pro Val Pro Glu Gln Phe Lys Thr Leu Trp Asn Gly Gln 
     450                455                460
Lys Leu Val Thr Thr Val Thr Glu Ile Ala Gly 
 465                470                475



<210> 2884
<211> 2171
<212> DNA
<213> Rattus norvegicus
<308> L12025
<400> 2884

ccttgccgc  cgctgctag  ttggatccg  gtggactac  gggactgaa  cggacccgg  60
accacatgg  cccactcgc  ggtgcctct  gctcccggg  gtggtcagc  gggctactg  120
ggctgctgc  gctgtcctg  tttacgctc  agaaagcgg  tggggagat  gctgtgcag  180
tgctctcca  ttcgaccgg  ttcttggga  ggtctacag  cttgcactg  agtctggct  240
ccaaagaca  tgtgacaat  actcagcta  catggatga  gagggatcc  gatggatcc  300
acccttccg  gcctgtctt  caccccaag  aggggccca  catctctga  ccagagagg  360
tgaagttct  ggttgccaa  gtgtacgag  atctgagga  cgcatctct  gccatctcg  420
acttgcgtg  agaagacga  ggcatctat  agtgtcaga  tgccacgtt  cccacaggc  480
gtaagagcg  caatgtctg  ctgaaggtg  tcgcccgac  taaaaacac  gcagaggcc  540
tggagccct  tcccacctt  atgccgcag  acgtggcca  atgcatctc  gctgatggt  600
accctcctg  acgaatcac  tggtcctcg  atgtgaatg  aagctaccg  gaaatgaag  660
aaacagggt  ccagccggg  accaccaca  ttatcagct  cctctccat  gtgccttct  720
gccaggcag  tggcacgaa  atcacctgc  cagtggaac  tgaaagctt  caggagccg  780
accagcagc  attgatcct  tccctacct  atccacccg  agtgtccat  tctggctat  840
aaggcaact  gtacattgg  ctcactaac  tgaacctga  ctgtgaagc  cgcagcaaa  900
caccgccca  caactatag  tggagcacg  ccacgggtc  ccttcccaa  tccactcat  960
tccaggaaa  cggcagtca  ctgctaatc  ccaccgtgg  tgacctcaa  aacacgatc  1020
ttgtgtgca  agccatcaa  gccctaggg  ctgggcagg  ccaagtgac  atcctagtt  1080
aagaggcat  tgagattct  ccgccaaag  caagcttag  cactggcta  atcattgcc  1140
tcgtctttt  tgtcctgat  atcggagta  tagcaggca  tgtattctg  aaatacagg  1200
gtggttgtg  tcggcagtc  aggacctta  acagggaga  cgtccgcta  tcagcagcg  1260
atggcgtct  tgtcccaaa  gtggagacg  acaacttga  gtgatggtg  tggggtaga  1320
agaactaag  aacttgaag  cataacaac  ggaacccta  ttccacaaa  gaaaaagcc  1380
ccagagaga  ttgactgtc  agtgtggcg  acatagcaa  gttgggggt  tccttggcc  1440
ctgccgaat  ccgcattgt  gaaaggact  atggaaccc  gtgtgctga  tcacacttg  1500
catctcagc  agcgagggc  acataaagc  aggttgagt  tagcacggc  gtagagaga  1560
gccctgtct  tacacaggc  agctaaggg  ctttgagac  gtcagaaac  gaagtcttt  1620
tttgggtaa  gtaaatcct  tacctcgtg  atgtgacaa  cttgaaaga  ttctacctc  1680
gagactcaa  tgcggactc  ctttatagc  gactcagct  gggctaacc  ctctctcct  1740
tctggacaa  gtctcagag  gtagccaaa  ctagaccga  actcacaga  gtccgtctg  1800
ctctacctc  caagtgctg  agttaaagg  ttgtgtgtg  cacactcct  tgctaggtc  1860
ttttaataa  gtaaatatt  aataaagta  tatatttat  aaaaaacta  ttataatat  1920
tattttttg  gacagtgtt  cctgtagcc  aggctgacc  caaacttac  atgtagcca  1980
gaatgatag  aaactaatt  attttaatt  gtcttcaag  ttaaacata  cccaacccc  2040
gctcctttc  ctctcttct  tcaatccat  ttcgtcttc  ttttcttcc  agacactat  2100
ctgatgtat  tcttcattg  aaacatttt  ttgaccttc  taaaaatgt  tgaaccaca  2160
ataaaaaaa  g  2171



<210> 2885
<211> 412
<212> PRT
<213> Rattus norvegicus
<308> AAB80767
<400> 2885

Met Ala Pro Leu Ala Gly Ala Ser Arg Ser Arg Val Trp Ser Ala Gly 
  1               5                  10                  15
Leu Leu Arg Leu Leu Leu Leu Ser Cys Phe Thr Leu Gln Lys Ala Gly 
             20                  25                  30
Gly Glu Ile Ala Val Gln Val Leu Ser Asn Ser Thr Gly Phe Leu Gly 
         35                  40                  45
Gly Ser Thr Val Leu His Cys Ser Leu Ala Ser Lys Asp Asn Val Thr 
     50                  55                  60
Ile Thr Gln Leu Thr Trp Met Lys Arg Asp Pro Asp Gly Ser His Pro 
 65                  70                  75                  80
Ser Val Pro Val Phe His Pro Lys Lys Gly Pro Ser Ile Ser Asp Pro 
                 85                  90                  95
Glu Arg Val Lys Phe Leu Val Ala Lys Val Tyr Glu Asp Leu Arg Asn 
             100                105                110
Ala Ser Leu Ala Ile Ser Asn Leu Arg Val Glu Asp Glu Gly Ile Tyr 
         115                120                125
Glu Cys Gln Ile Ala Thr Phe Pro Thr Gly Ser Lys Ser Ala Asn Val 
     130                135                140
Trp Leu Lys Val Phe Ala Arg Pro Lys Asn Thr Ala Glu Ala Leu Glu 
 145                150                155                160
Pro Ser Pro Thr Leu Met Pro Gln Asp Val Ala Lys Cys Ile Ser Ala 
                 165                170                175
Asp Gly His Pro Pro Gly Arg Ile Thr Trp Ser Ser Asn Val Asn Gly 
             180                185                190
Ser Tyr Arg Glu Met Lys Glu Thr Gly Ser Gln Pro Gly Thr Thr Thr 
         195                200                205
Val Ile Ser Tyr Leu Ser Met Val Pro Ser Ser Gln Ala Asp Gly Thr 
     210                215                220
Asn Ile Thr Cys Thr Val Glu His Glu Ser Phe Gln Glu Pro Asp Gln 
 225                230                235                240
Gln Pro Leu Ile Leu Ser Leu Pro Tyr Pro Pro Glu Val Ser Ile Ser 
                 245                250                255
Gly Tyr Glu Gly Asn Trp Tyr Ile Gly Leu Thr Asn Val Asn Leu Thr 
             260                265                270
Cys Glu Ala Arg Ser Lys Pro Pro Pro Thr Asn Tyr Ser Trp Ser Thr 
         275                280                285
Ala Thr Gly Pro Leu Pro Asn Ser Thr His Phe Gln Glu Asn Gly Ser 
     290                295                300
His Leu Leu Ile Ser Thr Val Asp Asp Leu Asn Asn Thr Ile Phe Val 
 305                310                315                320
Cys Lys Ala Ile Asn Ala Leu Gly Ser Gly Gln Gly Gln Val Thr Ile 
                 325                330                335
Leu Val Lys Glu Ala Ser Glu Ile Leu Pro Pro Lys Thr Ser Leu Gly 
             340                345                350
Thr Gly Tyr Ile Ile Ala Ile Val Phe Cys Val Leu Ile Ile Gly Val 
         355                360                365
Val Ala Gly Ile Val Phe Trp Lys Tyr Arg Arg Gly Cys Gly Arg Gln 
     370                375                380
Ser Arg Thr Leu Asp Arg Glu Asn Val Arg Tyr Ser Ala Ala Asn Gly 
 385                390                395                400
Val Ser Val Pro Asn Val Glu Thr Asn Asn Leu Arg 
                 405                410



<210> 2886
<211> 1254
<212> DNA
<213> Homo sapiens
<308> M24407
<400> 2886

atggcccga  ccatggccg  cgcgtggcc  ctgctgctg  tggcgctac  ggtgctgtc  60
tggccaccc  caggaaccg  ggacgtcgt  gtgcaggcg  ccacccagg  gcccggctt  120
ttgggcgac  ccgtgacgc  gccctgcta  ctacaggtg  ccaacatgg  ggtgacgca  180
gtgtcacag  tgacttggg  gcggcatgg  gaatctggc  gcatggccg  cttccacca  240
acgcagggc  ccagctatt  ggagtccaa  cggctggaa  tcgtggcag  cagactggg  300
gcggagctg  ggaatgcct  gctgaggat  ttcgggttg  gcgtagagg  tgaaggcaa  360
tacacctgc  tgttcgtca  gttcccgca  ggcagcagg  gcgtggata  ctggctccg  420
gtgcttgcc  agccccaga  cacagctga  gttcagaag  tccagctca  tggagagcc  480
gtgcccatg  cccgctgcg  ctccacagg  ggtcgcccg  cagcccaaa  cacctggca  540
tcagacctg  gcgggatgc  caatacgag  caggtgcca  ggttcctgt  tggcacagt  600
actgtcacc  gcctctgga  attggtgcc  tcaagccag  tggacggca  gaatgtgac  660
tgcaaggtg  agcacgaga  ctttgagaa  cctcagctg  tgactgtga  cctcaccgt  720
tactacccc  cagaggtat  catctctgg  tatgataac  actggtacc  tggccagaa  780
gaggccacc  tgacctgcg  tgctcgcag  aacccagag  ccacaggct  taattggag  840
acgaccatg  gtcccctgc  accctttgc  gtggcccag  gcgcccagc  cctgatccg  900
cctgtggac  aaccaatca  cacaacttt  atctgcaac  tcaccaatg  cctaggagc  960
cgccaggca  aactgaccg  ccaggtcaa  gagggacct  ccagtgagc  ctcaggcat  1020
tcccgtaac  ccatcatct  cctggttct  ggaatcctg  tttttctga  cctgctggg  1080
atcgggatt  atttctatt  gtccaaatg  tcccgtgag  tcctttggc  ctgtcatct  1140
tgtccctcg  gtacagagc  tgccagcgc  tcagctaat  ggcatgtct  ctattcagc  1200
gtgagcaga  agaacagct  ttcccagga  ccacagaca  agggcacaa  gtga  1254



<210> 2887
<211> 417
<212> PRT
<213> Homo sapiens
<308> P15151
<400> 2887

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
  1               5                  10                  15
Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
             20                  25                  30
Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
         35                  40                  45
Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
     50                  55                  60
Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
 65                  70                  75                  80
Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                 85                  90                  95
Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
             100                105                110
Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
         115                120                125
Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
     130                135                140
Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
 145                150                155                160
Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                 165                170                175
Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
             180                185                190
Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
         195                200                205
Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
     210                215                220
His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
 225                230                235                240
Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                 245                250                255
Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
             260                265                270
Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
         275                280                285
Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
     290                295                300
Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
 305                310                315                320
Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                 325                330                335
His Ser Gly Ile Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
             340                345                350
Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
         355                360                365
Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
     370                375                380
Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala 
 385                390                395                400
Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr 
                 405                410                415
Arg 
             420



<210> 2888
<211> 1700
<212> DNA
<213> Rattus norvegicus
<308> L12381
<400> 2888

ctttaactt  ttttactta  aacaattgt  cgtgtattt  acatgtgtt  cttttatat  60
tcatcaatg  agagtaacc  ttctacttg  tttttgttc  ggttgcaga  ttcagctac  120
atggggaac  tttttgaaa  gttgtttaa  agcctattc  ggaaaaagg  aatgcggat  180
ctcatggtg  gcttagatg  agctggcaa  acgacgatc  tgtacaaac  gaagctggg  240
gagattgtg  caaccatcc  caccatagg  ttcaacgtg  agaccgtag  atataaaaa  300
atcagcttc  cagtctggg  tgttggtgg  caggacaaa  tcagacctt  gtggcgaca  360
tacttccag  acactcaag  tctgatatt  gtggttgat  gtaacgaca  agagcgggt  420
aatgaggcc  gggaagaac  gaccagaat  ctagcagaa  atgagctca  agacgcagt  480
ttattggtg  ttgtaaaca  acaggatct  cctaatgct  tgaacgcag  agagatcac  540
gacaagctt  gcttacatt  acttcgcca  agaaactgg  acattcagg  tacctgtgc  600
accagtgga  atgggcttt  cgaaggcct  gactggctc  ccaaccaac  caagaacca  660
aagtgatca  aagcagccc  ttccccatg  cttgtggca  aggcagctg  cctttcccg  720
gtgcatgtg  gtgcgtgag  agccatgtg  ccgtgtggc  gggagtggg  cagctttct  780
acaccgtgc  ttatccacg  tatacgaac  ccagtactc  attttaaga  aaccagtgt  840
acatttgga  tgctaccgt  catttcacg  gctttgatg  tcttttcgc  gaggcctcc  900
cggtgtgat  gccagaata  ctctaggct  gaaaagaag  gagctggag  caggcaggt  960
ccgttgttg  catcctggg  ttggcctct  cacacactc  gaatcccgt  ggactttgg  1020
gtcctttta  aaaaagaaa  gaagggctg  cattctttc  attgtgcca  agctagcag  1080
tcacttgta  tgctttaaa  ctgtcaaga  gaaggatac  ttattacca  agtgtgaga  1140
gttcagagg  gaatacttc  ccagagttc  gttagttca  actgacgca  ttagctgtt  1200
tagtccaag  aatcagtga  ctttttcat  agagtatca  gactgtaac  ctagagaag  1260
ttccagcct  tcccatact  gccaaacgg  aactctgtg  gctgctggc  caacaggag  1320
ccagaactc  tccctaagc  tcctggtcc  cagcggagt  aaggttgtg  ggagtgaag  1380
gaggtagct  ttgtgtctg  catcacgtc  cagtcccct  aggctgctt  tcccacttc  1440
ctgctctgt  ctgagtgtt  ttcacatgc  gcagacagt  ctcctggtg  agttgtcac  1500
gtgtcccct  gtccaggtc  actgtgggc  tttgattag  atctgtttc  agaaccgca  1560
acccgtgag  tctgagtgt  tgtgagaaa  tcaggaggt  aatttagaa  atgaaggtc  1620
cagtggccc  catactccc  gggtggtgc  aaactttgc  ctgagaagc  ccttttctt  1680
agactgctc  cactctccct  1700



<210> 2889
<211> 181
<212> PRT
<213> Rattus norvegicus
<308> P16500
<400> 2889

Met Gly Asn Val Phe Glu Lys Leu Phe Lys Ser Leu Phe Gly Lys Lys 
  1               5                  10                  15
Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr 
             20                  25                  30
Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr 
         35                  40                  45
Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Ser Phe Thr 
     50                  55                  60
Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His 
 65                  70                  75                  80
Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                 85                  90                  95
Arg Glu Arg Val Asn Glu Ala Arg Glu Glu Leu Thr Arg Met Leu Ala 
             100                105                110
Glu Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Val Asn Lys Gln 
         115                120                125
Asp Leu Pro Asn Ala Met Asn Ala Ala Glu Ile Thr Asp Lys Leu Gly 
     130                135                140
Leu His Ser Leu Arg Gln Arg Asn Trp Tyr Ile Gln Ala Thr Cys Ala 
 145                150                155                160
Thr Ser Gly Asp Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Gln 
                 165                170                175
Leu Lys Asn Gln Lys 
             180



<210> 2890
<211> 589
<212> DNA
<213> Homo sapiens
<308> BE514791
<400> 2890

ttcctacct  cttatactt  gtaaccgag  gaatttcta  gacttcttg  tcatttctg  60
ggtattgtc  ttatatcct  acactatga  tgctacttg  atgcctctt  agggtctct  120
ctgcagggt  cccatgaat  gtggctgaa  ttgtgcaca  acaagtatc  ccagtgaca  180
gagtgcctt  tgaggcagc  attgcatct  catctgctg  cactctgct  ggctgactt  240
tgtagtttt  accactgat  ttcaggtcc  cctcacaga  ctctataaa  cgcttaaat  300
ctctttaca  catagactt  cagctactt  aagatagcc  gtcagccgc  acgtgactc  360
tttctccag  atctcccta  tactatgaa  gcggcagag  taacggaca  gctcggcct  420
cattccctc  gctacagaa  ctggcacat  caggctact  gtgccacta  tggacatgg  480
ctttacgaa  gcctgaact  gctcgccaa  cagttccag  accagaact  atcagaagg  540
tctattctt  gtgccttgt  gccacatca  ctagcctct  ctgtgtgca  589



<210> 2891
<211> 181
<212> PRT
<213> Homo sapiens
<308> NP_001649
<400> 2891

Met Gly Asn Ile Phe Ala Asn Leu Phe Lys Gly Leu Phe Gly Lys Lys 
  1               5                  10                  15
Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr 
             20                  25                  30
Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr 
         35                  40                  45
Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Ser Phe Thr 
     50                  55                  60
Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His 
 65                  70                  75                  80
Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                 85                  90                  95
Arg Glu Arg Val Asn Glu Ala Arg Glu Glu Leu Met Arg Met Leu Ala 
             100                105                110
Glu Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln 
         115                120                125
Asp Leu Pro Asn Ala Met Asn Ala Ala Glu Ile Thr Asp Lys Leu Gly 
     130                135                140
Leu His Ser Leu Arg His Arg Asn Trp Tyr Ile Gln Ala Thr Cys Ala 
 145                150                155                160
Thr Ser Gly Asp Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Gln 
                 165                170                175
Leu Arg Asn Gln Lys 
             180



<210> 2892
<211> 1058
<212> DNA
<213> Rattus norvegicus
<308> L12384
<400> 2892

cctccttct  ctgttgctc  ccatccccc  gcggccggc  ggttccagc  ctcgccccg  60
gtcccctgc  cgcgccccc  ccccgggcc  cgccatggg  ctcacggtg  ccgcgctct  120
ttcgcggat  ttcgggaag  agcagatgc  gatccttat  gttggcttg  atgcggctg  180
caagactac  atcctgtac  aactgaagt  gggggagat  gtcaccacc  tccccacca  240
aggcttcaa  gtggaaaca  tggaatata  gaacatctg  ttcacagtc  gggatgtcg  300
aggccagga  aagattcgg  ctttgtggc  gcactactt  cagaacact  agggcctca  360
ctttgtggt  gacagcaat  accgggagc  ggtccagga  tctgctgat  aactccaga  420
gatgctgca  gaggatgag  ttcgggatg  ggtgctgtt  gtgtttgcc  acaagcagg  480
catgcccaa  gccatgcct  tgagcgaac  gactgacaa  ctggggctt  aacacttgc  540
tagccgcac  tggtacgtc  aggccacct  tgccaccca  ggcacaggc  tgtatgatg  600
tctggactg  ctgtcccat  agctatcaa  gcgctagcc  gccaggggc  ggcccctgc  660
gcccggaag  tcccgcgtg  atcccggga  ggccagact  ccgggactc  tcaggcagt  720
cccttcctt  ccacttttc  tccccacag  caggcctct  ctcctgtgc  tgcctgcat  780
ctctctctt  ttgttggag  ctggagcct  gctctctgg  cacagaggg  tctgctctc  840
tgcctgctg  gacctgtgg  agggcttcc  ggccaaggc  ccctcttcc  ggggaggag  900
agggatctg  atttaattt  gttttggtt  tggtttttt  ggttttttt  tgttttggg  960
gtacccttg  ggccaggtt  ggggggagg  aagtgaggg  tccgggtgg  gctatgatg  1020
gggactgga  attgagtaa  aaatttgct  tggtttgt  1058



<210> 2893
<211> 179
<212> PRT
<213> Rattus norvegicus
<308> P26437
<400> 2893

Gly Leu Thr Val Ser Ala Leu Phe Ser Arg Ile Phe Gly Lys Lys Gln 
  1               5                  10                  15
Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr Ile 
             20                  25                  30
Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr Ile 
         35                  40                  45
Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Cys Phe Thr Val 
     50                  55                  60
Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His Tyr 
 65                  70                  75                  80
Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp Arg 
                 85                  90                  95
Glu Arg Val Gln Glu Ser Ala Asp Glu Leu Gln Lys Met Leu Gln Glu 
             100                105                110
Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln Asp 
         115                120                125
Met Pro Asn Ala Met Pro Val Ser Glu Leu Thr Asp Lys Leu Gly Leu 
     130                135                140
Gln His Leu Arg Ser Arg Thr Trp Tyr Val Gln Ala Thr Cys Ala Thr 
 145                150                155                160
Gln Gly Thr Gly Leu Tyr Asp Gly Leu Asp Trp Leu Ser His Glu Leu 
                 165                170                175
Ser Lys Arg 
             180



<210> 2894
<211> 957
<212> DNA
<213> Homo sapiens
<308> BI837414
<400> 2894

cgccatggg  ctcaccgtg  ccgcgctct  ttcgcggat  ttcgggaag  agcagatgc  60
gattctcat  gttggcttg  atgcggctg  caagaccac  atcctgtac  aactgaagt  120
ggggagatg  caccaccat  ccaaccata  gcttcaatg  agaaacagt  gaatataag  180
acatctgtt  cacagtctg  gacgtggga  gccaggaca  gattcggcc  ctgtggcgg  240
actacttcc  gaacactca  gtggagtgn  gggagggga  tttctaacc  cacgggaaa  300
ggtgttagg  ctgggagaa  agaantgtt  gcctaggct  ggcccccag  ccaaggaaa  360
aacccttcc  cacttctac  ccttctgtt  ggctatccc  tactcactc  tcagaactc  420
ccttagtct  ccccagctt  gacttctct  tagaagcag  attctggga  caggctgcc  480
gatttagcc  tcataacat  tctttattt  cttgcacat  tttggataa  ctacttcct  540
tttgcagtg  ggtctctag  ttgtgccat  actcctgta  agcttctat  gagttctgt  600
aacttctgt  gagtttact  gatgagaag  attgacaca  ttacaaatg  gaagaaaac  660
gaaagggcc  cactacggt  tgtcccagg  agaagtgat  gcttctcct  tcttccttc  720
ttcctgccc  gggcctcat  tttgttggt  gacagtaat  accgggagc  ggtccaaga  780
tctgctgat  aactccaga  gaatgctgn  gggaggacg  agctgcggg  tgcagtgct  840
ctgggattt  caacaagca  gacatggcc  aaggcctgg  cgggagcga  ctgactgac  900
agcgggaga  cagacatta  gcagcggac  gggaatgtc  aggccactg  gcaccca  957



<210> 2895
<211> 179
<212> PRT
<213> Homo sapiens
<308> P26437
<400> 2895

Gly Leu Thr Val Ser Ala Leu Phe Ser Arg Ile Phe Gly Lys Lys Gln 
  1               5                  10                  15
Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr Ile 
             20                  25                  30
Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr Ile 
         35                  40                  45
Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Cys Phe Thr Val 
     50                  55                  60
Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His Tyr 
 65                  70                  75                  80
Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp Arg 
                 85                  90                  95
Glu Arg Val Gln Glu Ser Ala Asp Glu Leu Gln Lys Met Leu Gln Glu 
             100                105                110
Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln Asp 
         115                120                125
Met Pro Asn Ala Met Pro Val Ser Glu Leu Thr Asp Lys Leu Gly Leu 
     130                135                140
Gln His Leu Arg Ser Arg Thr Trp Tyr Val Gln Ala Thr Cys Ala Thr 
 145                150                155                160
Gln Gly Thr Gly Leu Tyr Asp Gly Leu Asp Trp Leu Ser His Glu Leu 
                 165                170                175
Ser Lys Arg 
             180



<210> 2896
<211> 3296
<212> DNA
<213> Rattus norvegicus
<308> L13151
<400> 2896

gggggggac  cgcctgggt  gggcggctc  cagcccggg  ctggtggcc  ccggggctc  60
cgggcggcg  ggtagctag  ggagagcgg  cttcaacat  atggcggcc  aggcgggca  120
tgaggaagg  ggcccggcg  ccgcgggga  cggcggcgc  gcggccacg  gctccagcg  180
ctacccagc  gcgtgccgg  taaagttac  cgcggcccc  ccgatggca  tcgccccgt  240
tcctgggct  gcggacacc  acctggctg  ggccctcgg  gggggagcc  cgtcggggt  300
cgggttcct  gggaccggg  cggtgtctg  tgtcctggg  ggcgccgcg  tgaccggcg  360
tgctgcagc  ggcgtggcg  gtgctgcag  cgctggacc  gccggagac  tcgctctca  420
caaggggac  ctctctctg  ctgctgaga  tctcgggcc  ggcggcgga  tccctcctc  480
gccgcctcc  cctctgttg  ctcctttgg  ctccggtct  gggacagtg  atgaaggtg  540
ctccttgga  ggaccagaa  acgaggagg  agaggtggc  ataccgctg  ccgcacctc  600
aactaacca  tggtatcat  gaaaacttg  tagaactat  gcagaagaa  gcctcaggc  660
ggcagggaa  tctggaagc  accttataa  agagagtga  cggaggcca  ggtcctttg  720
actttcatt  cttagccag  caaatgttg  caatcattt  aggattatt  ctatgtgtg  780
tgattacta  attggtgga  ggcgttttt  ttcactctc  gacctaata  gatattaca  840
tcacgtttc  tgtttactt  aaggagaaa  attactcta  ccagttgca  caccagagc  900
agtagaaga  agaagacgt  tacgagcca  tctgcccta  acaaaagta  cagacactg  960
tgaaataag  ttcttaaag  gagatatgt  cattgttca  aatgagtta  aagatggat  1020
gatgtgggt  acaaaccta  gaacagatg  gcaaggcct  attgttgag  acctagtgg  1080
agaggtggg  cgagaagaa  atccacatg  aggcaaaat  tggttccat  ggaagattt  1140
caaacaaga  gcttataat  tattaatga  agttggcca  gtctgcagc  ttcttgtga  1200
gccctcaga  aatactcct  gagattatt  cctgtattt  cggaccaat  aaaatatcc  1260
gcgatttaa  atttgtcca  cacctaaca  tcagttcat  atgggaggc  gctattata  1320
cagtattgg  gacatcata  accactatc  gaaagaaca  attgttgaa  gctattatc  1380
taaggaacc  gtaccaatg  aggatcaag  acaagtact  aatgacact  tggatggga  1440
ggaaatcta  aatacaatt  gtcgtaaaa  aaaggatgc  ttttataaa  atattgtta  1500
aaaaggtta  cttctgaag  agggcaaag  aaaacgttg  aaaaattta  attttatct  1560
agagggcag  gatgcccaa  ttatttatt  tgaaagtga  aaacgagct  caaaaccaa  1620
agggctaat  gatctcagt  tatgttctg  ctacgttgt  catgatagt  tcttcggca  1680
gccaaactg  tttcagata  tcgttcagc  ctttagtga  gaacattac  tcttttact  1740
tgcaggaga  actccagaa  aagcagagg  ttggatgaa  ggcctgcaa  cattttgca  1800
tttacggaa  agtagccca  ggacatcta  taaacgcct  cgtcaggtc  gcagccttg  1860
attacatat  gaagaagct  ataaactac  agtaaaaca  ttcactaat  catattgta  1920
catctactt  aatagtgtc  aagtagcaa  aactcatgc  agggagggg  aaaacccag  1980
atggtcaga  gagtttgtc  ttgatgatc  tcctcctga  atcaataga  ttgaaatca  2040
acttagtaa  aaaacaaag  aaagtaaag  tccagatat  ttatttatg  gttgccagt  2100
gagcaggtt  cagaaagga  atgccacag  tgaatggtt  ctgctaagt  ctcatatac  2160
actaaaagg  attgaacca  gatctctgc  tgttcgagc  cgatactct  tggaaaaaa  2220
catgccaga  gaagagtac  gtgaattta  agagcttat  ctgcagaag  aacttcacg  2280
agtctatgc  ctatcacac  tatgtggac  agaccgaac  ctactggcc  gcatcctac  2340
gaaaatatt  cttcatgaa  agcttgagt  attgttgtt  tgcacacta  atgacagag  2400
gataagtat  gaagatgaa  ccactaccc  atttcgagc  acaacactt  cgagtacct  2460
gatggagca  tacatgaaa  ccacggcca  gcagtttgt  catcatgct  tgaaagact  2520
cattttaaa  ataatggaa  gcaagcaat  atgtgagtt  agtccatca  agttagaaa  2580
aaatgaaga  gtgaacact  atttagcac  cctattgag  atactttca  agcttgtgg  2640
gaaaatatt  atggcttca  aaatacttc  accgacact  agatatatt  atgggtgtt  2700
acagaaatc  gttcagcat  agtggccta  aaataacac  atgagaaca  gagttgtta  2760
tggttttgt  tttcttcgg  ttatctgcc  agctatcct  aatccacgg  tgtttaata  2820
catctcaga  tctccatct  ctattgctg  aagaacact  acattagtg  ctaaatctg  2880
gcagaattt  gcaaatctt  tggaatttg  agctaagga  ccttatatg  aaggtgtca  2940
tccattcat  aaaagtaat  aacatcgca  gatcatgtt  ttagatgaa  ttgggaatg  3000
acctgagct  ccggacact  cagaacatt  tagaactga  ctgtctcgt  acttagcag  3060
attgcatga  atttgtgta  ctcattcag  tgaactgag  acactcagt  atgagcgtg  3120
tgtacagca  catgtactg  aaaagcttc  ggcaataac  gaactgctt  aacaaaagc  3180
aaaccagta  acaaaaacc  atgatgtca  gtagcagcc  ggtgttctg  atggattcg  3240
catgcccaa  gtggtaatt  acatcacca  gtctccttt  ctcttgcca  aaagcc  3296



<210> 2897
<211> 1039
<212> PRT
<213> Rattus norvegicus
<308> L13151
<400> 2897

Met Met Ala Ala Glu Ala Gly Ser Glu Glu Gly Gly Pro Ala Thr Ala 
  1               5                  10                  15
Gly Thr Gly Gly Ala Ala Ala Thr Gly Ser Ser Ala Tyr Pro Ala Ala 
             20                  25                  30
Cys Arg Val Lys Leu Pro Ala Ala Pro Pro Met Ala Val Ala Pro Cys 
         35                  40                  45
Pro Gly Leu Ala Asp Thr Asp Leu Ala Ala Ala Leu Gly Gly Gly Ala 
     50                  55                  60
Ala Ser Gly Ser Gly Phe Leu Gly Thr Gly Pro Val Ser Gly Val Leu 
 65                  70                  75                  80
Gly Gly Ala Ala Leu Thr Gly Gly Ala Ala Ala Gly Val Ala Gly Ala 
                 85                  90                  95
Ala Ala Ala Gly Pro Ala Gly Asp Ile Ala Leu Thr Lys Gly Thr Leu 
             100                105                110
Ser Leu Pro Ala Glu Thr Leu Gly Pro Gly Gly Gly Phe Pro Pro Leu 
         115                120                125
Pro Pro Pro Pro Leu Leu Pro Pro Leu Gly Ser Gly Leu Gly Thr Val 
     130                135                140
Asp Glu Gly Asp Ser Leu Asp Gly Pro Glu Tyr Glu Glu Glu Glu Val 
 145                150                155                160
Ala Ile Pro Leu Thr Ala Pro Pro Thr Asn Gln Trp Tyr His Gly Lys 
                 165                170                175
Leu Asp Arg Thr Ile Ala Glu Glu Arg Leu Arg Gln Ala Gly Lys Ser 
             180                185                190
Gly Ser Tyr Leu Ile Arg Glu Ser Asp Arg Arg Pro Gly Ser Phe Val 
         195                200                205
Leu Ser Phe Leu Ser Gln Thr Asn Val Val Asn His Phe Arg Ile Ile 
     210                215                220
Ala Met Cys Gly Asp Tyr Tyr Ile Gly Gly Arg Arg Phe Ser Ser Leu 
 225                230                235                240
Ser Asp Leu Ile Gly Tyr Tyr Ser His Val Ser Cys Leu Leu Lys Gly 
                 245                250                255
Glu Lys Leu Leu Tyr Pro Val Ala Pro Pro Glu Pro Val Glu Asp Arg 
             260                265                270
Arg Arg Val Arg Ala Ile Leu Pro Tyr Thr Lys Val Pro Asp Thr Asp 
         275                280                285
Glu Ile Ser Phe Leu Lys Gly Asp Met Phe Ile Val His Asn Glu Leu 
     290                295                300
Glu Asp Gly Trp Met Trp Val Thr Asn Leu Arg Thr Asp Glu Gln Gly 
 305                310                315                320
Leu Ile Val Glu Asp Leu Val Glu Glu Val Gly Arg Glu Glu Asp Pro 
                 325                330                335
His Glu Gly Lys Ile Trp Phe His Gly Lys Ile Ser Lys Gln Glu Ala 
             340                345                350
Tyr Asn Leu Leu Met Thr Val Gly Gln Val Cys Ser Phe Leu Val Arg 
         355                360                365
Pro Ser Asp Asn Thr Pro Gly Asp Tyr Ser Leu Tyr Phe Arg Thr Asn 
     370                375                380
Glu Asn Ile Gln Arg Phe Lys Ile Cys Pro Thr Pro Asn Asn Gln Phe 
 385                390                395                400
Met Met Gly Gly Arg Tyr Tyr Asn Ser Ile Gly Asp Ile Ile Asp His 
                 405                410                415
Tyr Arg Lys Glu Gln Ile Val Glu Gly Tyr Tyr Leu Lys Glu Pro Val 
             420                425                430
Pro Met Gln Asp Gln Gly Gln Val Leu Asn Asp Thr Val Asp Gly Lys 
         435                440                445
Glu Ile Tyr Asn Thr Ile Arg Arg Lys Thr Lys Asp Ala Phe Tyr Lys 
     450                455                460
Asn Ile Val Lys Lys Gly Tyr Leu Leu Lys Lys Gly Lys Gly Lys Arg 
 465                470                475                480
Trp Lys Asn Leu Tyr Phe Ile Leu Glu Gly Ser Asp Ala Gln Leu Ile 
                 485                490                495
Tyr Phe Glu Ser Glu Lys Arg Ala Thr Lys Pro Lys Gly Leu Ile Asp 
             500                505                510
Leu Ser Val Cys Ser Val Tyr Val Val His Asp Ser Leu Phe Gly Arg 
         515                520                525
Pro Asn Cys Phe Gln Ile Val Val Gln His Phe Ser Glu Glu His Tyr 
     530                535                540
Ile Phe Tyr Phe Ala Gly Glu Thr Pro Glu Gln Ala Glu Asp Trp Met 
 545                550                555                560
Lys Gly Leu Gln Ala Phe Cys Ser Leu Arg Lys Ser Ser Pro Gly Thr 
                 565                570                575
Ser Asn Lys Arg Leu Arg Gln Val Ser Ser Leu Val Leu His Ile Glu 
             580                585                590
Glu Ala His Lys Leu Pro Val Lys His Phe Thr Asn Pro Tyr Cys Asn 
         595                600                605
Ile Tyr Leu Asn Ser Val Gln Val Ala Lys Thr His Ala Arg Glu Gly 
     610                615                620
Gln Asn Pro Val Trp Ser Glu Glu Phe Val Phe Asp Asp Leu Pro Pro 
 625                630                635                640
Asp Ile Asn Arg Phe Glu Ile Thr Leu Ser Asn Lys Thr Lys Lys Ser 
                 645                650                655
Lys Asp Pro Asp Ile Leu Phe Met Arg Cys Gln Leu Ser Arg Leu Gln 
             660                665                670
Lys Gly His Ala Thr Asp Glu Trp Phe Leu Leu Ser Ser His Ile Pro 
         675                680                685
Leu Lys Gly Ile Glu Pro Gly Ser Leu Arg Val Arg Ala Arg Tyr Ser 
     690                695                700
Met Glu Lys Ile Met Pro Glu Glu Glu Tyr Ser Glu Phe Lys Glu Leu 
 705                710                715                720
Ile Leu Gln Lys Glu Leu His Val Val Tyr Ala Leu Ser His Val Cys 
                 725                730                735
Gly Gln Asp Arg Thr Leu Leu Ala Ser Ile Leu Leu Lys Ile Phe Leu 
             740                745                750
His Glu Lys Leu Glu Ser Leu Leu Leu Cys Thr Leu Asn Asp Arg Glu 
         755                760                765
Ile Ser Met Glu Asp Glu Ala Thr Thr Leu Phe Arg Ala Thr Thr Leu 
     770                775                780
Ala Ser Thr Leu Met Glu Gln Tyr Met Lys Ala Thr Ala Thr Gln Phe 
 785                790                795                800
Val His His Ala Leu Lys Asp Ser Ile Leu Lys Ile Met Glu Ser Lys 
                 805                810                815
Gln Ser Cys Glu Leu Ser Pro Ser Lys Leu Glu Lys Asn Glu Asp Val 
             820                825                830
Asn Thr Asn Leu Ala His Leu Leu Ser Ile Leu Ser Glu Leu Val Glu 
         835                840                845
Lys Ile Phe Met Ala Ser Glu Ile Leu Pro Pro Thr Leu Arg Tyr Ile 
     850                855                860
Tyr Gly Cys Leu Gln Lys Ser Val Gln His Lys Trp Pro Thr Asn Asn 
 865                870                875                880
Thr Met Arg Thr Arg Val Val Ser Gly Phe Val Phe Leu Arg Leu Ile 
                 885                890                895
Cys Pro Ala Ile Leu Asn Pro Arg Met Phe Asn Ile Ile Ser Asp Ser 
             900                905                910
Pro Ser Pro Ile Ala Ala Arg Thr Leu Thr Leu Val Ala Lys Ser Val 
         915                920                925
Gln Asn Leu Ala Asn Leu Val Glu Phe Gly Ala Lys Glu Pro Tyr Met 
     930                935                940
Glu Gly Val Asn Pro Phe Ile Lys Ser Asn Lys His Arg Met Ile Met 
 945                950                955                960
Phe Leu Asp Glu Leu Gly Asn Val Pro Glu Leu Pro Asp Thr Thr Glu 
                 965                970                975
His Ser Arg Thr Asp Leu Ser Arg Asp Leu Ala Ala Leu His Glu Ile 
             980                985                990
Cys Val Ala His Ser Asp Glu Leu Arg Thr Leu Ser Asn Glu Arg Gly 
         995                1000                1005
Val Gln Gln His Val Leu Lys Lys Leu Leu Ala Ile Thr Glu Leu Leu 
     1010                1015                1020
Gln Gln Lys Gln Asn Gln Tyr Thr Lys Thr Asn Asp Val Arg Ter 
 1025                1030                1035



<210> 2898
<211> 4307
<212> DNA
<213> Homo sapiens
<308> M23379
<400> 2898

cctcagcct  gggagctga  ggggagacg  gtctgggtg  ggctgctcg  agcccgggc  60
tggtggccc  tggggctcc  gggcgggca  ggtagggca  agtagagcg  gcttcaaca  120
gatggcggc  gaggccggc  gtgaggagg  cggcccggt  acagccgga  ctggaggag  180
cggcgcggc  gcgggctcc  gtgcctatc  cgcagtgtg  cgggtgaag  tacccgcgg  240
cctgcctgt  gcagccgcc  cctatcctg  gctggtgga  accggagtg  ctggaactc  300
gggtggcgg  gccgctttg  ggtcagagt  cctaggagc  gggtctgtg  caggggcac  360
ggggggagc  ggactgaca  ggggaggta  tgctgctgg  gtagctggt  ctgctgctg  420
cgtggccgg  gctgctgtt  ctggaccta  tggagacat  gctctcacc  aactgccca  480
ttcgttgct  gctgagact  tcgggccag  cggcggttt  ccccctctg  cccctcccc  540
ttacctgcc  cctttgggg  cgggcctcg  gacagtgga  gaaggtgac  ctctggatg  600
accagaata  gaggaggaa  aggtggcca  accgttgac  gctcctcca  ctaaccagt  660
gtatcacgg  aaacttgac  gaacgatag  agaagaacg  ctcaggcag  cagggaagt  720
tggcagtta  cttataaga  agagtgatc  gaggccagg  tcctttgta  tttcatttc  780
tagccagat  aatgttgtc  accatttta  gattattgc  atgtgtgga  attactaca  840
tggtggaag  cgtttttct  cactgtcag  cctaatagg  tattacagt  atgtttctt  900
tttgcttaa  ggagaaaaa  tactttacc  agttgcacc  ccagagcca  tagaagata  960
aaggcgtgt  cgagctatt  taccttaca  aaaagtacc  gacactgat  aaataagtt  1020
cttaaaagg  gatatgttc  ttgttcata  tgaattaga  gatggatgg  tgtgggtta  1080
aaatttaag  acagatgaa  aaggcctta  tgttgaaga  ctagtagaa  aggtgggcc  1140
ggaagaaga  ccacatgaa  gaaaaatat  gttccatgg  aagatttcc  aacaggaag  1200
ttataattt  ctaatgaca  ttggtcaag  ctgcagttt  cttgtgagg  cctcagata  1260
tactcctgg  gattattca  tttatttcc  gaccaatga  aatattcag  gatttaaaa  1320
atgtccaac  ccaaacaat  agtttatga  gggaggccg  tattataac  gcattgggg  1380
catcataga  cactatcga  aagaacaga  tgttgaagg  tattatctt  aggaacctg  1440
accaatgca  gatcaagaa  aagtactca  tgacacagt  gatggcaag  aaatctata  1500
taccatccg  cgtaaaaca  aggatgcct  ttataaaaa  attgttaag  aaggttatc  1560
tctgaaaaa  ggcaaagga  aacgttgga  aaatttata  tttatctta  agggtagtg  1620
tgcccaact  atttatttt  aaagcgaaa  acgagctac  aaaccaaaa  gattaatag  1680
tctcagtgt  tgttctgtc  atgtcgttc  tgatagtct  tttggcagg  caaactgtt  1740
tcagatagt  gttcagcac  ttagtgaag  acattacat  ttttacttt  caggagaaa  1800
tccagaaca  gcagaggat  ggatgaaag  tctgcaggc  ttttgcaat  tacggaaaa  1860
tagtccagg  acatccaat  aacgccttc  tcaggtcag  agccttgtt  tacatattg  1920
agaagccca  aaactccca  taaaacatt  tactaatcc  tattgtaac  tctacctga  1980
tagtgtcca  gtagcaaaa  ctcatgcaa  ggaagggca  aacccagta  ggtcagaag  2040
gtttgtctt  gatgatctt  ctcctgaca  caatagatt  gaaataact  ttagtaata  2100
aacaaagaa  agcaaagat  ctgatatct  atttatgcg  tgccagttg  gccgattac  2160
gaaagggca  gccacagat  aatggtttc  gctcagctc  catatacca  taaaaggta  2220
tgaaccagg  tccctgcgt  ttcgagcac  atactctat  gaaaaaatc  tgccagaag  2280
agagtacag  gaatttaaa  agcttatac  gcaaaagga  cttcatgta  tctatgctt  2340
atcacatgt  tgtggacaa  accgaacac  actggccag  atcctactg  ggatttttc  2400
tcacgaaaa  cttgaatcg  tgttgttat  cacactaaa  gacagagaa  taagcatgg  2460
agatgaagc  actacccta  ttcgagcca  aacacttgc  agcaccttg  tggagcagt  2520
tatgaaagc  actgctaca  agtttgttc  tcatgcttt  aaagactct  ttttaaaga  2580
aatggaaag  aagcagtct  gtgagttaa  tccatcaaa  ttagaaaaa  atgaagatg  2640
gaacactaa  ttaacacac  tattgaaca  actttcaga  cttgtggag  aaatattca  2700
ggcttcaga  atacttcca  cgacattga  atatattta  gggtgttta  agaaatctg  2760
tcagcataa  tggcctaca  ataccacca  gagaacaag  gttgttagt  gttttgttt  2820
tcttcgact  atctgtcct  ccatcctga  tccacggat  ttcaatatc  tctcagatt  2880
tccatctcc  attgctgca  gaacactga  attagtggc  aaatctgtg  agaacttag  2940
aaatcttgt  gaatttgga  ctaaggagc  ctacatgga  ggtgtcaat  cattcatca  3000
aagcaacaa  catcgtatg  tcatgtttt  agatgaact  gggaatgta  ctgaacttc  3060
ggacactac  gagcattct  gaacggacc  gtcccgtga  ttagcagca  tgcatgaga  3120
ttgcgtggc  cattcagat  aacttcgaa  gctcagtaa  gagcgtggt  cacagcagc  3180
cgtattgaa  aagcttctg  ctataacag  actgcttca  caaaaacaa  accagtata  3240
aaaaaccaa  gatgtcagg  agcagcctt  gccccagtg  tctgcatgg  ttcagcatg  3300
ccaacatgg  aattcactt  agtttaatg  ctcctttgc  cttgccaaa  aatagcaca  3360
ttttccaca  tccagtgat  tgtgagcta  gcaaacaaa  tccaagatt  tgctggtga  3420
taactatgc  agcaacctt  taagctatc  gtgcaggat  tttgcacta  ttccacatg  3480
aatcaatct  taacaacct  tgagccttg  tgtacagac  acctttcac  aaacgaaat  3540
ctatgactg  atcttgata  ctcgaactt  caaaatata  tttcagtac  cccagttgc  3600
aaagttttg  tgtctctta  agaaagaac  atgaaatca  ctgacaaga  acacattct  3660
attgacaat  gtgtataac  ggattgcag  ctgttctta  tgtaactac  tcctgatta  3720
gaatatgac  atttgactg  tcaatgatt  tttgtattt  cagtttcca  agtttgtca  3780
tataatagg  acaatcttt  ctgtatact  ttaaaaaat  ctctgctat  tctcttgct  3840
gaactgttg  aagaaaata  atagaatga  ctattgctc  tcagcttta  tttttaaac  3900
tacgactta  tttgttgaa  ttgtcaaag  ctgtattta  atctcataa  gctttgtta  3960
atgtttaca  gtaaatagt  tgaattcag  aaatattat  ggttgttgt  ttgatcaat  4020
catgttacc  attcaacca  tttatagac  accaatttc  tttatgtta  ctagaatgc  4080
tttgttaaa  gttatttgt  cattatttg  gctacccct  tgattatgc  gacaacctc  4140
tcagctgcc  aacttatcc  tctttgaac  tctgactac  tgttgtatc  gctggatat  4200
tagttcaac  gtatagttt  atttacttc  gtatgtgta  ttttgtgaa  tattcacaa  4260
ggttaagtt  aaataaaac  aagggatat  ttgcaaaaa  aaaaaaa  4307



<210> 2899
<211> 1047
<212> PRT
<213> Homo sapiens
<308> P20936
<400> 2899

Met Met Ala Ala Glu Ala Gly Ser Glu Glu Gly Gly Pro Val Thr Ala 
  1               5                  10                  15
Gly Ala Gly Gly Gly Gly Ala Ala Ala Gly Ser Ser Ala Tyr Pro Ala 
             20                  25                  30
Val Cys Arg Val Lys Ile Pro Ala Ala Leu Pro Val Ala Ala Ala Pro 
         35                  40                  45
Tyr Pro Gly Leu Val Glu Thr Gly Val Ala Gly Thr Leu Gly Gly Gly 
     50                  55                  60
Ala Ala Leu Gly Ser Glu Phe Leu Gly Ala Gly Ser Val Ala Gly Ala 
 65                  70                  75                  80
Leu Gly Gly Ala Gly Leu Thr Gly Gly Gly Thr Ala Ala Gly Val Ala 
                 85                  90                  95
Gly Ala Ala Ala Gly Val Ala Gly Ala Ala Val Ala Gly Pro Ser Gly 
             100                105                110
Asp Met Ala Leu Thr Lys Leu Pro Thr Ser Leu Leu Ala Glu Thr Leu 
         115                120                125
Gly Pro Gly Gly Gly Phe Pro Pro Leu Pro Pro Pro Pro Tyr Leu Pro 
     130                135                140
Pro Leu Gly Ala Gly Leu Gly Thr Val Asp Glu Gly Asp Ser Leu Asp 
 145                150                155                160
Gly Pro Glu Tyr Glu Glu Glu Glu Val Ala Ile Pro Leu Thr Ala Pro 
                 165                170                175
Pro Thr Asn Gln Trp Tyr His Gly Lys Leu Asp Arg Thr Ile Ala Glu 
             180                185                190
Glu Arg Leu Arg Gln Ala Gly Lys Ser Gly Ser Tyr Leu Ile Arg Glu 
         195                200                205
Ser Asp Arg Arg Pro Gly Ser Phe Val Leu Ser Phe Leu Ser Gln Met 
     210                215                220
Asn Val Val Asn His Phe Arg Ile Ile Ala Met Cys Gly Asp Tyr Tyr 
 225                230                235                240
Ile Gly Gly Arg Arg Phe Ser Ser Leu Ser Asp Leu Ile Gly Tyr Tyr 
                 245                250                255
Ser His Val Ser Cys Leu Leu Lys Gly Glu Lys Leu Leu Tyr Pro Val 
             260                265                270
Ala Pro Pro Glu Pro Val Glu Asp Arg Arg Arg Val Arg Ala Ile Leu 
         275                280                285
Pro Tyr Thr Lys Val Pro Asp Thr Asp Glu Ile Ser Phe Leu Lys Gly 
     290                295                300
Asp Met Phe Ile Val His Asn Glu Leu Glu Asp Gly Trp Met Trp Val 
 305                310                315                320
Thr Asn Leu Arg Thr Asp Glu Gln Gly Leu Ile Val Glu Asp Leu Val 
                 325                330                335
Glu Glu Val Gly Arg Glu Glu Asp Pro His Glu Gly Lys Ile Trp Phe 
             340                345                350
His Gly Lys Ile Ser Lys Gln Glu Ala Tyr Asn Leu Leu Met Thr Val 
         355                360                365
Gly Gln Val Cys Ser Phe Leu Val Arg Pro Ser Asp Asn Thr Pro Gly 
     370                375                380
Asp Tyr Ser Leu Tyr Phe Arg Thr Asn Glu Asn Ile Gln Arg Phe Lys 
 385                390                395                400
Ile Cys Pro Thr Pro Asn Asn Gln Phe Met Met Gly Gly Arg Tyr Tyr 
                 405                410                415
Asn Ser Ile Gly Asp Ile Ile Asp His Tyr Arg Lys Glu Gln Ile Val 
             420                425                430
Glu Gly Tyr Tyr Leu Lys Glu Pro Val Pro Met Gln Asp Gln Glu Gln 
         435                440                445
Val Leu Asn Asp Thr Val Asp Gly Lys Glu Ile Tyr Asn Thr Ile Arg 
     450                455                460
Arg Lys Thr Lys Asp Ala Phe Tyr Lys Asn Ile Val Lys Lys Gly Tyr 
 465                470                475                480
Leu Leu Lys Lys Gly Lys Gly Lys Arg Trp Lys Asn Leu Tyr Phe Ile 
                 485                490                495
Leu Glu Gly Ser Asp Ala Gln Leu Ile Tyr Phe Glu Ser Glu Lys Arg 
             500                505                510
Ala Thr Lys Pro Lys Gly Leu Ile Asp Leu Ser Val Cys Ser Val Tyr 
         515                520                525
Val Val His Asp Ser Leu Phe Gly Arg Pro Asn Cys Phe Gln Ile Val 
     530                535                540
Val Gln His Phe Ser Glu Glu His Tyr Ile Phe Tyr Phe Ala Gly Glu 
 545                550                555                560
Thr Pro Glu Gln Ala Glu Asp Trp Met Lys Gly Leu Gln Ala Phe Cys 
                 565                570                575
Asn Leu Arg Lys Ser Ser Pro Gly Thr Ser Asn Lys Arg Leu Arg Gln 
             580                585                590
Val Ser Ser Leu Val Leu His Ile Glu Glu Ala His Lys Leu Pro Val 
         595                600                605
Lys His Phe Thr Asn Pro Tyr Cys Asn Ile Tyr Leu Asn Ser Val Gln 
     610                615                620
Val Ala Lys Thr His Ala Arg Glu Gly Gln Asn Pro Val Trp Ser Glu 
 625                630                635                640
Glu Phe Val Phe Asp Asp Leu Pro Pro Asp Ile Asn Arg Phe Glu Ile 
                 645                650                655
Thr Leu Ser Asn Lys Thr Lys Lys Ser Lys Asp Pro Asp Ile Leu Phe 
             660                665                670
Met Arg Cys Gln Leu Ser Arg Leu Gln Lys Gly His Ala Thr Asp Glu 
         675                680                685
Trp Phe Leu Leu Ser Ser His Ile Pro Leu Lys Gly Ile Glu Pro Gly 
     690                695                700
Ser Leu Arg Val Arg Ala Arg Tyr Ser Met Glu Lys Ile Met Pro Glu 
 705                710                715                720
Glu Glu Tyr Ser Glu Phe Lys Glu Leu Ile Leu Gln Lys Glu Leu His 
                 725                730                735
Val Val Tyr Ala Leu Ser His Val Cys Gly Gln Asp Arg Thr Leu Leu 
             740                745                750
Ala Ser Ile Leu Leu Arg Ile Phe Leu His Glu Lys Leu Glu Ser Leu 
         755                760                765
Leu Leu Cys Thr Leu Asn Asp Arg Glu Ile Ser Met Glu Asp Glu Ala 
     770                775                780
Thr Thr Leu Phe Arg Ala Thr Thr Leu Ala Ser Thr Leu Met Glu Gln 
 785                790                795                800
Tyr Met Lys Ala Thr Ala Thr Gln Phe Val His His Ala Leu Lys Asp 
                 805                810                815
Ser Ile Leu Lys Ile Met Glu Ser Lys Gln Ser Cys Glu Leu Ser Pro 
             820                825                830
Ser Lys Leu Glu Lys Asn Glu Asp Val Asn Thr Asn Leu Thr His Leu 
         835                840                845
Leu Asn Ile Leu Ser Glu Leu Val Glu Lys Ile Phe Met Ala Ser Glu 
     850                855                860
Ile Leu Pro Pro Thr Leu Arg Tyr Ile Tyr Gly Cys Leu Gln Lys Ser 
 865                870                875                880
Val Gln His Lys Trp Pro Thr Asn Thr Thr Met Arg Thr Arg Val Val 
                 885                890                895
Ser Gly Phe Val Phe Leu Arg Leu Ile Cys Pro Ala Ile Leu Asn Pro 
             900                905                910
Arg Met Phe Asn Ile Ile Ser Asp Ser Pro Ser Pro Ile Ala Ala Arg 
         915                920                925
Thr Leu Ile Leu Val Ala Lys Ser Val Gln Asn Leu Ala Asn Leu Val 
     930                935                940
Glu Phe Gly Ala Lys Glu Pro Tyr Met Glu Gly Val Asn Pro Phe Ile 
 945                950                955                960
Lys Ser Asn Lys His Arg Met Ile Met Phe Leu Asp Glu Leu Gly Asn 
                 965                970                975
Val Pro Glu Leu Pro Asp Thr Thr Glu His Ser Arg Thr Asp Leu Ser 
             980                985                990
Arg Asp Leu Ala Ala Leu His Glu Ile Cys Val Ala His Ser Asp Glu 
         995                1000                1005
Leu Arg Thr Leu Ser Asn Glu Arg Gly Ala Gln Gln His Val Leu Lys 
     1010                1015                1020
Lys Leu Leu Ala Ile Thr Glu Leu Leu Gln Gln Lys Gln Asn Gln Tyr 
 1025                1030                1035                1040
Thr Lys Thr Asn Asp Val Arg 
                 1045



<210> 2900
<211> 3296
<212> DNA
<213> Rattus norvegicus
<308> L13151
<400> 2900

gggggggac  cgcctgggt  gggcggctc  cagcccggg  ctggtggcc  ccggggctc  60
cgggcggcg  ggtagctag  ggagagcgg  cttcaacat  atggcggcc  aggcgggca  120
tgaggaagg  ggcccggcg  ccgcgggga  cggcggcgc  gcggccacg  gctccagcg  180
ctacccagc  gcgtgccgg  taaagttac  cgcggcccc  ccgatggca  tcgccccgt  240
tcctgggct  gcggacacc  acctggctg  ggccctcgg  gggggagcc  cgtcggggt  300
cgggttcct  gggaccggg  cggtgtctg  tgtcctggg  ggcgccgcg  tgaccggcg  360
tgctgcagc  ggcgtggcg  gtgctgcag  cgctggacc  gccggagac  tcgctctca  420
caaggggac  ctctctctg  ctgctgaga  tctcgggcc  ggcggcgga  tccctcctc  480
gccgcctcc  cctctgttg  ctcctttgg  ctccggtct  gggacagtg  atgaaggtg  540
ctccttgga  ggaccagaa  acgaggagg  agaggtggc  ataccgctg  ccgcacctc  600
aactaacca  tggtatcat  gaaaacttg  tagaactat  gcagaagaa  gcctcaggc  660
ggcagggaa  tctggaagc  accttataa  agagagtga  cggaggcca  ggtcctttg  720
actttcatt  cttagccag  caaatgttg  caatcattt  aggattatt  ctatgtgtg  780
tgattacta  attggtgga  ggcgttttt  ttcactctc  gacctaata  gatattaca  840
tcacgtttc  tgtttactt  aaggagaaa  attactcta  ccagttgca  caccagagc  900
agtagaaga  agaagacgt  tacgagcca  tctgcccta  acaaaagta  cagacactg  960
tgaaataag  ttcttaaag  gagatatgt  cattgttca  aatgagtta  aagatggat  1020
gatgtgggt  acaaaccta  gaacagatg  gcaaggcct  attgttgag  acctagtgg  1080
agaggtggg  cgagaagaa  atccacatg  aggcaaaat  tggttccat  ggaagattt  1140
caaacaaga  gcttataat  tattaatga  agttggcca  gtctgcagc  ttcttgtga  1200
gccctcaga  aatactcct  gagattatt  cctgtattt  cggaccaat  aaaatatcc  1260
gcgatttaa  atttgtcca  cacctaaca  tcagttcat  atgggaggc  gctattata  1320
cagtattgg  gacatcata  accactatc  gaaagaaca  attgttgaa  gctattatc  1380
taaggaacc  gtaccaatg  aggatcaag  acaagtact  aatgacact  tggatggga  1440
ggaaatcta  aatacaatt  gtcgtaaaa  aaaggatgc  ttttataaa  atattgtta  1500
aaaaggtta  cttctgaag  agggcaaag  aaaacgttg  aaaaattta  attttatct  1560
agagggcag  gatgcccaa  ttatttatt  tgaaagtga  aaacgagct  caaaaccaa  1620
agggctaat  gatctcagt  tatgttctg  ctacgttgt  catgatagt  tcttcggca  1680
gccaaactg  tttcagata  tcgttcagc  ctttagtga  gaacattac  tcttttact  1740
tgcaggaga  actccagaa  aagcagagg  ttggatgaa  ggcctgcaa  cattttgca  1800
tttacggaa  agtagccca  ggacatcta  taaacgcct  cgtcaggtc  gcagccttg  1860
attacatat  gaagaagct  ataaactac  agtaaaaca  ttcactaat  catattgta  1920
catctactt  aatagtgtc  aagtagcaa  aactcatgc  agggagggg  aaaacccag  1980
atggtcaga  gagtttgtc  ttgatgatc  tcctcctga  atcaataga  ttgaaatca  2040
acttagtaa  aaaacaaag  aaagtaaag  tccagatat  ttatttatg  gttgccagt  2100
gagcaggtt  cagaaagga  atgccacag  tgaatggtt  ctgctaagt  ctcatatac  2160
actaaaagg  attgaacca  gatctctgc  tgttcgagc  cgatactct  tggaaaaaa  2220
catgccaga  gaagagtac  gtgaattta  agagcttat  ctgcagaag  aacttcacg  2280
agtctatgc  ctatcacac  tatgtggac  agaccgaac  ctactggcc  gcatcctac  2340
gaaaatatt  cttcatgaa  agcttgagt  attgttgtt  tgcacacta  atgacagag  2400
gataagtat  gaagatgaa  ccactaccc  atttcgagc  acaacactt  cgagtacct  2460
gatggagca  tacatgaaa  ccacggcca  gcagtttgt  catcatgct  tgaaagact  2520
cattttaaa  ataatggaa  gcaagcaat  atgtgagtt  agtccatca  agttagaaa  2580
aaatgaaga  gtgaacact  atttagcac  cctattgag  atactttca  agcttgtgg  2640
gaaaatatt  atggcttca  aaatacttc  accgacact  agatatatt  atgggtgtt  2700
acagaaatc  gttcagcat  agtggccta  aaataacac  atgagaaca  gagttgtta  2760
tggttttgt  tttcttcgg  ttatctgcc  agctatcct  aatccacgg  tgtttaata  2820
catctcaga  tctccatct  ctattgctg  aagaacact  acattagtg  ctaaatctg  2880
gcagaattt  gcaaatctt  tggaatttg  agctaagga  ccttatatg  aaggtgtca  2940
tccattcat  aaaagtaat  aacatcgca  gatcatgtt  ttagatgaa  ttgggaatg  3000
acctgagct  ccggacact  cagaacatt  tagaactga  ctgtctcgt  acttagcag  3060
attgcatga  atttgtgta  ctcattcag  tgaactgag  acactcagt  atgagcgtg  3120
tgtacagca  catgtactg  aaaagcttc  ggcaataac  gaactgctt  aacaaaagc  3180
aaaccagta  acaaaaacc  atgatgtca  gtagcagcc  ggtgttctg  atggattcg  3240
catgcccaa  gtggtaatt  acatcacca  gtctccttt  ctcttgcca  aaagcc  3296



<210> 2901
<211> 1039
<212> PRT
<213> Rattus norvegicus
<308> L13151
<400> 2901

Met Met Ala Ala Glu Ala Gly Ser Glu Glu Gly Gly Pro Ala Thr Ala 
  1               5                  10                  15
Gly Thr Gly Gly Ala Ala Ala Thr Gly Ser Ser Ala Tyr Pro Ala Ala 
             20                  25                  30
Cys Arg Val Lys Leu Pro Ala Ala Pro Pro Met Ala Val Ala Pro Cys 
         35                  40                  45
Pro Gly Leu Ala Asp Thr Asp Leu Ala Ala Ala Leu Gly Gly Gly Ala 
     50                  55                  60
Ala Ser Gly Ser Gly Phe Leu Gly Thr Gly Pro Val Ser Gly Val Leu 
 65                  70                  75                  80
Gly Gly Ala Ala Leu Thr Gly Gly Ala Ala Ala Gly Val Ala Gly Ala 
                 85                  90                  95
Ala Ala Ala Gly Pro Ala Gly Asp Ile Ala Leu Thr Lys Gly Thr Leu 
             100                105                110
Ser Leu Pro Ala Glu Thr Leu Gly Pro Gly Gly Gly Phe Pro Pro Leu 
         115                120                125
Pro Pro Pro Pro Leu Leu Pro Pro Leu Gly Ser Gly Leu Gly Thr Val 
     130                135                140
Asp Glu Gly Asp Ser Leu Asp Gly Pro Glu Tyr Glu Glu Glu Glu Val 
 145                150                155                160
Ala Ile Pro Leu Thr Ala Pro Pro Thr Asn Gln Trp Tyr His Gly Lys 
                 165                170                175
Leu Asp Arg Thr Ile Ala Glu Glu Arg Leu Arg Gln Ala Gly Lys Ser 
             180                185                190
Gly Ser Tyr Leu Ile Arg Glu Ser Asp Arg Arg Pro Gly Ser Phe Val 
         195                200                205
Leu Ser Phe Leu Ser Gln Thr Asn Val Val Asn His Phe Arg Ile Ile 
     210                215                220
Ala Met Cys Gly Asp Tyr Tyr Ile Gly Gly Arg Arg Phe Ser Ser Leu 
 225                230                235                240
Ser Asp Leu Ile Gly Tyr Tyr Ser His Val Ser Cys Leu Leu Lys Gly 
                 245                250                255
Glu Lys Leu Leu Tyr Pro Val Ala Pro Pro Glu Pro Val Glu Asp Arg 
             260                265                270
Arg Arg Val Arg Ala Ile Leu Pro Tyr Thr Lys Val Pro Asp Thr Asp 
         275                280                285
Glu Ile Ser Phe Leu Lys Gly Asp Met Phe Ile Val His Asn Glu Leu 
     290                295                300
Glu Asp Gly Trp Met Trp Val Thr Asn Leu Arg Thr Asp Glu Gln Gly 
 305                310                315                320
Leu Ile Val Glu Asp Leu Val Glu Glu Val Gly Arg Glu Glu Asp Pro 
                 325                330                335
His Glu Gly Lys Ile Trp Phe His Gly Lys Ile Ser Lys Gln Glu Ala 
             340                345                350
Tyr Asn Leu Leu Met Thr Val Gly Gln Val Cys Ser Phe Leu Val Arg 
         355                360                365
Pro Ser Asp Asn Thr Pro Gly Asp Tyr Ser Leu Tyr Phe Arg Thr Asn 
     370                375                380
Glu Asn Ile Gln Arg Phe Lys Ile Cys Pro Thr Pro Asn Asn Gln Phe 
 385                390                395                400
Met Met Gly Gly Arg Tyr Tyr Asn Ser Ile Gly Asp Ile Ile Asp His 
                 405                410                415
Tyr Arg Lys Glu Gln Ile Val Glu Gly Tyr Tyr Leu Lys Glu Pro Val 
             420                425                430
Pro Met Gln Asp Gln Gly Gln Val Leu Asn Asp Thr Val Asp Gly Lys 
         435                440                445
Glu Ile Tyr Asn Thr Ile Arg Arg Lys Thr Lys Asp Ala Phe Tyr Lys 
     450                455                460
Asn Ile Val Lys Lys Gly Tyr Leu Leu Lys Lys Gly Lys Gly Lys Arg 
 465                470                475                480
Trp Lys Asn Leu Tyr Phe Ile Leu Glu Gly Ser Asp Ala Gln Leu Ile 
                 485                490                495
Tyr Phe Glu Ser Glu Lys Arg Ala Thr Lys Pro Lys Gly Leu Ile Asp 
             500                505                510
Leu Ser Val Cys Ser Val Tyr Val Val His Asp Ser Leu Phe Gly Arg 
         515                520                525
Pro Asn Cys Phe Gln Ile Val Val Gln His Phe Ser Glu Glu His Tyr 
     530                535                540
Ile Phe Tyr Phe Ala Gly Glu Thr Pro Glu Gln Ala Glu Asp Trp Met 
 545                550                555                560
Lys Gly Leu Gln Ala Phe Cys Ser Leu Arg Lys Ser Ser Pro Gly Thr 
                 565                570                575
Ser Asn Lys Arg Leu Arg Gln Val Ser Ser Leu Val Leu His Ile Glu 
             580                585                590
Glu Ala His Lys Leu Pro Val Lys His Phe Thr Asn Pro Tyr Cys Asn 
         595                600                605
Ile Tyr Leu Asn Ser Val Gln Val Ala Lys Thr His Ala Arg Glu Gly 
     610                615                620
Gln Asn Pro Val Trp Ser Glu Glu Phe Val Phe Asp Asp Leu Pro Pro 
 625                630                635                640
Asp Ile Asn Arg Phe Glu Ile Thr Leu Ser Asn Lys Thr Lys Lys Ser 
                 645                650                655
Lys Asp Pro Asp Ile Leu Phe Met Arg Cys Gln Leu Ser Arg Leu Gln 
             660                665                670
Lys Gly His Ala Thr Asp Glu Trp Phe Leu Leu Ser Ser His Ile Pro 
         675                680                685
Leu Lys Gly Ile Glu Pro Gly Ser Leu Arg Val Arg Ala Arg Tyr Ser 
     690                695                700
Met Glu Lys Ile Met Pro Glu Glu Glu Tyr Ser Glu Phe Lys Glu Leu 
 705                710                715                720
Ile Leu Gln Lys Glu Leu His Val Val Tyr Ala Leu Ser His Val Cys 
                 725                730                735
Gly Gln Asp Arg Thr Leu Leu Ala Ser Ile Leu Leu Lys Ile Phe Leu 
             740                745                750
His Glu Lys Leu Glu Ser Leu Leu Leu Cys Thr Leu Asn Asp Arg Glu 
         755                760                765
Ile Ser Met Glu Asp Glu Ala Thr Thr Leu Phe Arg Ala Thr Thr Leu 
     770                775                780
Ala Ser Thr Leu Met Glu Gln Tyr Met Lys Ala Thr Ala Thr Gln Phe 
 785                790                795                800
Val His His Ala Leu Lys Asp Ser Ile Leu Lys Ile Met Glu Ser Lys 
                 805                810                815
Gln Ser Cys Glu Leu Ser Pro Ser Lys Leu Glu Lys Asn Glu Asp Val 
             820                825                830
Asn Thr Asn Leu Ala His Leu Leu Ser Ile Leu Ser Glu Leu Val Glu 
         835                840                845
Lys Ile Phe Met Ala Ser Glu Ile Leu Pro Pro Thr Leu Arg Tyr Ile 
     850                855                860
Tyr Gly Cys Leu Gln Lys Ser Val Gln His Lys Trp Pro Thr Asn Asn 
 865                870                875                880
Thr Met Arg Thr Arg Val Val Ser Gly Phe Val Phe Leu Arg Leu Ile 
                 885                890                895
Cys Pro Ala Ile Leu Asn Pro Arg Met Phe Asn Ile Ile Ser Asp Ser 
             900                905                910
Pro Ser Pro Ile Ala Ala Arg Thr Leu Thr Leu Val Ala Lys Ser Val 
         915                920                925
Gln Asn Leu Ala Asn Leu Val Glu Phe Gly Ala Lys Glu Pro Tyr Met 
     930                935                940
Glu Gly Val Asn Pro Phe Ile Lys Ser Asn Lys His Arg Met Ile Met 
 945                950                955                960
Phe Leu Asp Glu Leu Gly Asn Val Pro Glu Leu Pro Asp Thr Thr Glu 
                 965                970                975
His Ser Arg Thr Asp Leu Ser Arg Asp Leu Ala Ala Leu His Glu Ile 
             980                985                990
Cys Val Ala His Ser Asp Glu Leu Arg Thr Leu Ser Asn Glu Arg Gly 
         995                1000                1005
Val Gln Gln His Val Leu Lys Lys Leu Leu Ala Ile Thr Glu Leu Leu 
     1010                1015                1020
Gln Gln Lys Gln Asn Gln Tyr Thr Lys Thr Asn Asp Val Arg Ter 
 1025                1030                1035



<210> 2902
<211> 4307
<212> DNA
<213> Homo sapiens
<308> M23379
<400> 2902

cctcagcct  gggagctga  ggggagacg  gtctgggtg  ggctgctcg  agcccgggc  60
tggtggccc  tggggctcc  gggcgggca  ggtagggca  agtagagcg  gcttcaaca  120
gatggcggc  gaggccggc  gtgaggagg  cggcccggt  acagccgga  ctggaggag  180
cggcgcggc  gcgggctcc  gtgcctatc  cgcagtgtg  cgggtgaag  tacccgcgg  240
cctgcctgt  gcagccgcc  cctatcctg  gctggtgga  accggagtg  ctggaactc  300
gggtggcgg  gccgctttg  ggtcagagt  cctaggagc  gggtctgtg  caggggcac  360
ggggggagc  ggactgaca  ggggaggta  tgctgctgg  gtagctggt  ctgctgctg  420
cgtggccgg  gctgctgtt  ctggaccta  tggagacat  gctctcacc  aactgccca  480
ttcgttgct  gctgagact  tcgggccag  cggcggttt  ccccctctg  cccctcccc  540
ttacctgcc  cctttgggg  cgggcctcg  gacagtgga  gaaggtgac  ctctggatg  600
accagaata  gaggaggaa  aggtggcca  accgttgac  gctcctcca  ctaaccagt  660
gtatcacgg  aaacttgac  gaacgatag  agaagaacg  ctcaggcag  cagggaagt  720
tggcagtta  cttataaga  agagtgatc  gaggccagg  tcctttgta  tttcatttc  780
tagccagat  aatgttgtc  accatttta  gattattgc  atgtgtgga  attactaca  840
tggtggaag  cgtttttct  cactgtcag  cctaatagg  tattacagt  atgtttctt  900
tttgcttaa  ggagaaaaa  tactttacc  agttgcacc  ccagagcca  tagaagata  960
aaggcgtgt  cgagctatt  taccttaca  aaaagtacc  gacactgat  aaataagtt  1020
cttaaaagg  gatatgttc  ttgttcata  tgaattaga  gatggatgg  tgtgggtta  1080
aaatttaag  acagatgaa  aaggcctta  tgttgaaga  ctagtagaa  aggtgggcc  1140
ggaagaaga  ccacatgaa  gaaaaatat  gttccatgg  aagatttcc  aacaggaag  1200
ttataattt  ctaatgaca  ttggtcaag  ctgcagttt  cttgtgagg  cctcagata  1260
tactcctgg  gattattca  tttatttcc  gaccaatga  aatattcag  gatttaaaa  1320
atgtccaac  ccaaacaat  agtttatga  gggaggccg  tattataac  gcattgggg  1380
catcataga  cactatcga  aagaacaga  tgttgaagg  tattatctt  aggaacctg  1440
accaatgca  gatcaagaa  aagtactca  tgacacagt  gatggcaag  aaatctata  1500
taccatccg  cgtaaaaca  aggatgcct  ttataaaaa  attgttaag  aaggttatc  1560
tctgaaaaa  ggcaaagga  aacgttgga  aaatttata  tttatctta  agggtagtg  1620
tgcccaact  atttatttt  aaagcgaaa  acgagctac  aaaccaaaa  gattaatag  1680
tctcagtgt  tgttctgtc  atgtcgttc  tgatagtct  tttggcagg  caaactgtt  1740
tcagatagt  gttcagcac  ttagtgaag  acattacat  ttttacttt  caggagaaa  1800
tccagaaca  gcagaggat  ggatgaaag  tctgcaggc  ttttgcaat  tacggaaaa  1860
tagtccagg  acatccaat  aacgccttc  tcaggtcag  agccttgtt  tacatattg  1920
agaagccca  aaactccca  taaaacatt  tactaatcc  tattgtaac  tctacctga  1980
tagtgtcca  gtagcaaaa  ctcatgcaa  ggaagggca  aacccagta  ggtcagaag  2040
gtttgtctt  gatgatctt  ctcctgaca  caatagatt  gaaataact  ttagtaata  2100
aacaaagaa  agcaaagat  ctgatatct  atttatgcg  tgccagttg  gccgattac  2160
gaaagggca  gccacagat  aatggtttc  gctcagctc  catatacca  taaaaggta  2220
tgaaccagg  tccctgcgt  ttcgagcac  atactctat  gaaaaaatc  tgccagaag  2280
agagtacag  gaatttaaa  agcttatac  gcaaaagga  cttcatgta  tctatgctt  2340
atcacatgt  tgtggacaa  accgaacac  actggccag  atcctactg  ggatttttc  2400
tcacgaaaa  cttgaatcg  tgttgttat  cacactaaa  gacagagaa  taagcatgg  2460
agatgaagc  actacccta  ttcgagcca  aacacttgc  agcaccttg  tggagcagt  2520
tatgaaagc  actgctaca  agtttgttc  tcatgcttt  aaagactct  ttttaaaga  2580
aatggaaag  aagcagtct  gtgagttaa  tccatcaaa  ttagaaaaa  atgaagatg  2640
gaacactaa  ttaacacac  tattgaaca  actttcaga  cttgtggag  aaatattca  2700
ggcttcaga  atacttcca  cgacattga  atatattta  gggtgttta  agaaatctg  2760
tcagcataa  tggcctaca  ataccacca  gagaacaag  gttgttagt  gttttgttt  2820
tcttcgact  atctgtcct  ccatcctga  tccacggat  ttcaatatc  tctcagatt  2880
tccatctcc  attgctgca  gaacactga  attagtggc  aaatctgtg  agaacttag  2940
aaatcttgt  gaatttgga  ctaaggagc  ctacatgga  ggtgtcaat  cattcatca  3000
aagcaacaa  catcgtatg  tcatgtttt  agatgaact  gggaatgta  ctgaacttc  3060
ggacactac  gagcattct  gaacggacc  gtcccgtga  ttagcagca  tgcatgaga  3120
ttgcgtggc  cattcagat  aacttcgaa  gctcagtaa  gagcgtggt  cacagcagc  3180
cgtattgaa  aagcttctg  ctataacag  actgcttca  caaaaacaa  accagtata  3240
aaaaaccaa  gatgtcagg  agcagcctt  gccccagtg  tctgcatgg  ttcagcatg  3300
ccaacatgg  aattcactt  agtttaatg  ctcctttgc  cttgccaaa  aatagcaca  3360
ttttccaca  tccagtgat  tgtgagcta  gcaaacaaa  tccaagatt  tgctggtga  3420
taactatgc  agcaacctt  taagctatc  gtgcaggat  tttgcacta  ttccacatg  3480
aatcaatct  taacaacct  tgagccttg  tgtacagac  acctttcac  aaacgaaat  3540
ctatgactg  atcttgata  ctcgaactt  caaaatata  tttcagtac  cccagttgc  3600
aaagttttg  tgtctctta  agaaagaac  atgaaatca  ctgacaaga  acacattct  3660
attgacaat  gtgtataac  ggattgcag  ctgttctta  tgtaactac  tcctgatta  3720
gaatatgac  atttgactg  tcaatgatt  tttgtattt  cagtttcca  agtttgtca  3780
tataatagg  acaatcttt  ctgtatact  ttaaaaaat  ctctgctat  tctcttgct  3840
gaactgttg  aagaaaata  atagaatga  ctattgctc  tcagcttta  tttttaaac  3900
tacgactta  tttgttgaa  ttgtcaaag  ctgtattta  atctcataa  gctttgtta  3960
atgtttaca  gtaaatagt  tgaattcag  aaatattat  ggttgttgt  ttgatcaat  4020
catgttacc  attcaacca  tttatagac  accaatttc  tttatgtta  ctagaatgc  4080
tttgttaaa  gttatttgt  cattatttg  gctacccct  tgattatgc  gacaacctc  4140
tcagctgcc  aacttatcc  tctttgaac  tctgactac  tgttgtatc  gctggatat  4200
tagttcaac  gtatagttt  atttacttc  gtatgtgta  ttttgtgaa  tattcacaa  4260
ggttaagtt  aaataaaac  aagggatat  ttgcaaaaa  aaaaaaa  4307



<210> 2903
<211> 1047
<212> PRT
<213> Homo sapiens
<308> P20936
<400> 2903

Met Met Ala Ala Glu Ala Gly Ser Glu Glu Gly Gly Pro Val Thr Ala 
  1               5                  10                  15
Gly Ala Gly Gly Gly Gly Ala Ala Ala Gly Ser Ser Ala Tyr Pro Ala 
             20                  25                  30
Val Cys Arg Val Lys Ile Pro Ala Ala Leu Pro Val Ala Ala Ala Pro 
         35                  40                  45
Tyr Pro Gly Leu Val Glu Thr Gly Val Ala Gly Thr Leu Gly Gly Gly 
     50                  55                  60
Ala Ala Leu Gly Ser Glu Phe Leu Gly Ala Gly Ser Val Ala Gly Ala 
 65                  70                  75                  80
Leu Gly Gly Ala Gly Leu Thr Gly Gly Gly Thr Ala Ala Gly Val Ala 
                 85                  90                  95
Gly Ala Ala Ala Gly Val Ala Gly Ala Ala Val Ala Gly Pro Ser Gly 
             100                105                110
Asp Met Ala Leu Thr Lys Leu Pro Thr Ser Leu Leu Ala Glu Thr Leu 
         115                120                125
Gly Pro Gly Gly Gly Phe Pro Pro Leu Pro Pro Pro Pro Tyr Leu Pro 
     130                135                140
Pro Leu Gly Ala Gly Leu Gly Thr Val Asp Glu Gly Asp Ser Leu Asp 
 145                150                155                160
Gly Pro Glu Tyr Glu Glu Glu Glu Val Ala Ile Pro Leu Thr Ala Pro 
                 165                170                175
Pro Thr Asn Gln Trp Tyr His Gly Lys Leu Asp Arg Thr Ile Ala Glu 
             180                185                190
Glu Arg Leu Arg Gln Ala Gly Lys Ser Gly Ser Tyr Leu Ile Arg Glu 
         195                200                205
Ser Asp Arg Arg Pro Gly Ser Phe Val Leu Ser Phe Leu Ser Gln Met 
     210                215                220
Asn Val Val Asn His Phe Arg Ile Ile Ala Met Cys Gly Asp Tyr Tyr 
 225                230                235                240
Ile Gly Gly Arg Arg Phe Ser Ser Leu Ser Asp Leu Ile Gly Tyr Tyr 
                 245                250                255
Ser His Val Ser Cys Leu Leu Lys Gly Glu Lys Leu Leu Tyr Pro Val 
             260                265                270
Ala Pro Pro Glu Pro Val Glu Asp Arg Arg Arg Val Arg Ala Ile Leu 
         275                280                285
Pro Tyr Thr Lys Val Pro Asp Thr Asp Glu Ile Ser Phe Leu Lys Gly 
     290                295                300
Asp Met Phe Ile Val His Asn Glu Leu Glu Asp Gly Trp Met Trp Val 
 305                310                315                320
Thr Asn Leu Arg Thr Asp Glu Gln Gly Leu Ile Val Glu Asp Leu Val 
                 325                330                335
Glu Glu Val Gly Arg Glu Glu Asp Pro His Glu Gly Lys Ile Trp Phe 
             340                345                350
His Gly Lys Ile Ser Lys Gln Glu Ala Tyr Asn Leu Leu Met Thr Val 
         355                360                365
Gly Gln Val Cys Ser Phe Leu Val Arg Pro Ser Asp Asn Thr Pro Gly 
     370                375                380
Asp Tyr Ser Leu Tyr Phe Arg Thr Asn Glu Asn Ile Gln Arg Phe Lys 
 385                390                395                400
Ile Cys Pro Thr Pro Asn Asn Gln Phe Met Met Gly Gly Arg Tyr Tyr 
                 405                410                415
Asn Ser Ile Gly Asp Ile Ile Asp His Tyr Arg Lys Glu Gln Ile Val 
             420                425                430
Glu Gly Tyr Tyr Leu Lys Glu Pro Val Pro Met Gln Asp Gln Glu Gln 
         435                440                445
Val Leu Asn Asp Thr Val Asp Gly Lys Glu Ile Tyr Asn Thr Ile Arg 
     450                455                460
Arg Lys Thr Lys Asp Ala Phe Tyr Lys Asn Ile Val Lys Lys Gly Tyr 
 465                470                475                480
Leu Leu Lys Lys Gly Lys Gly Lys Arg Trp Lys Asn Leu Tyr Phe Ile 
                 485                490                495
Leu Glu Gly Ser Asp Ala Gln Leu Ile Tyr Phe Glu Ser Glu Lys Arg 
             500                505                510
Ala Thr Lys Pro Lys Gly Leu Ile Asp Leu Ser Val Cys Ser Val Tyr 
         515                520                525
Val Val His Asp Ser Leu Phe Gly Arg Pro Asn Cys Phe Gln Ile Val 
     530                535                540
Val Gln His Phe Ser Glu Glu His Tyr Ile Phe Tyr Phe Ala Gly Glu 
 545                550                555                560
Thr Pro Glu Gln Ala Glu Asp Trp Met Lys Gly Leu Gln Ala Phe Cys 
                 565                570                575
Asn Leu Arg Lys Ser Ser Pro Gly Thr Ser Asn Lys Arg Leu Arg Gln 
             580                585                590
Val Ser Ser Leu Val Leu His Ile Glu Glu Ala His Lys Leu Pro Val 
         595                600                605
Lys His Phe Thr Asn Pro Tyr Cys Asn Ile Tyr Leu Asn Ser Val Gln 
     610                615                620
Val Ala Lys Thr His Ala Arg Glu Gly Gln Asn Pro Val Trp Ser Glu 
 625                630                635                640
Glu Phe Val Phe Asp Asp Leu Pro Pro Asp Ile Asn Arg Phe Glu Ile 
                 645                650                655
Thr Leu Ser Asn Lys Thr Lys Lys Ser Lys Asp Pro Asp Ile Leu Phe 
             660                665                670
Met Arg Cys Gln Leu Ser Arg Leu Gln Lys Gly His Ala Thr Asp Glu 
         675                680                685
Trp Phe Leu Leu Ser Ser His Ile Pro Leu Lys Gly Ile Glu Pro Gly 
     690                695                700
Ser Leu Arg Val Arg Ala Arg Tyr Ser Met Glu Lys Ile Met Pro Glu 
 705                710                715                720
Glu Glu Tyr Ser Glu Phe Lys Glu Leu Ile Leu Gln Lys Glu Leu His 
                 725                730                735
Val Val Tyr Ala Leu Ser His Val Cys Gly Gln Asp Arg Thr Leu Leu 
             740                745                750
Ala Ser Ile Leu Leu Arg Ile Phe Leu His Glu Lys Leu Glu Ser Leu 
         755                760                765
Leu Leu Cys Thr Leu Asn Asp Arg Glu Ile Ser Met Glu Asp Glu Ala 
     770                775                780
Thr Thr Leu Phe Arg Ala Thr Thr Leu Ala Ser Thr Leu Met Glu Gln 
 785                790                795                800
Tyr Met Lys Ala Thr Ala Thr Gln Phe Val His His Ala Leu Lys Asp 
                 805                810                815
Ser Ile Leu Lys Ile Met Glu Ser Lys Gln Ser Cys Glu Leu Ser Pro 
             820                825                830
Ser Lys Leu Glu Lys Asn Glu Asp Val Asn Thr Asn Leu Thr His Leu 
         835                840                845
Leu Asn Ile Leu Ser Glu Leu Val Glu Lys Ile Phe Met Ala Ser Glu 
     850                855                860
Ile Leu Pro Pro Thr Leu Arg Tyr Ile Tyr Gly Cys Leu Gln Lys Ser 
 865                870                875                880
Val Gln His Lys Trp Pro Thr Asn Thr Thr Met Arg Thr Arg Val Val 
                 885                890                895
Ser Gly Phe Val Phe Leu Arg Leu Ile Cys Pro Ala Ile Leu Asn Pro 
             900                905                910
Arg Met Phe Asn Ile Ile Ser Asp Ser Pro Ser Pro Ile Ala Ala Arg 
         915                920                925
Thr Leu Ile Leu Val Ala Lys Ser Val Gln Asn Leu Ala Asn Leu Val 
     930                935                940
Glu Phe Gly Ala Lys Glu Pro Tyr Met Glu Gly Val Asn Pro Phe Ile 
 945                950                955                960
Lys Ser Asn Lys His Arg Met Ile Met Phe Leu Asp Glu Leu Gly Asn 
                 965                970                975
Val Pro Glu Leu Pro Asp Thr Thr Glu His Ser Arg Thr Asp Leu Ser 
             980                985                990
Arg Asp Leu Ala Ala Leu His Glu Ile Cys Val Ala His Ser Asp Glu 
         995                1000                1005
Leu Arg Thr Leu Ser Asn Glu Arg Gly Ala Gln Gln His Val Leu Lys 
     1010                1015                1020
Lys Leu Leu Ala Ile Thr Glu Leu Leu Gln Gln Lys Gln Asn Gln Tyr 
 1025                1030                1035                1040
Thr Lys Thr Asn Asp Val Arg 
                 1045



<210> 2904
<211> 558
<212> DNA
<213> Rattus norvegicus
<308> L13406
<400> 2904

ttttcagca  ccaagagtt  gttgaagaa  ccggatggg  taaaggagt  aactgagag  60
tcaaatacc  ccattgagg  tgaagacgt  aaagcacga  agcaagaga  catcaaagt  120
actgagcag  tgattgaag  tatcaacaa  ggggacttc  aggcttaca  gaaaatctg  180
gatccaggc  tcactgcct  tgaacccga  gcattgggc  acttagtgg  agggatgga  240
tttcacaga  tctactttg  aaatgcttt  cccaaaatc  ataaaccaa  ccacactat  300
atcctgaac  ctcacgtac  cctggtagg  gatgatgca  cctgcatag  atacattcg  360
ctcacacag  acatggatg  aaatggaat  ccaaagaca  tgcagtcag  agagactcg  420
gtgtggcac  gccgtgatg  gaagtggca  aatattcac  ttcatcgtt  ggggtcccc  480
acagtcccc  tcaagccac  ctgtattcc  aatgggaaa  aaaacttct  aggaggcac  540
tctttgtgg  aaaacatc  558



<210> 2905
<211> 533
<212> PRT
<213> Rattus norvegicus
<308> AAA41479
<400> 2905

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
  1               5                  10                  15
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
             20                  25                  30
Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
         115                120                125
Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
             180                185                190
Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
 305                310                315                320
Leu Lys Lys Pro Asp Gly Val Lys Ile Asn Asn Lys Ala Asn Val Val 
                 325                330                335
Thr Ser Pro Lys Glu Asn Ile Pro Thr Pro Ala Leu Glu Pro Gln Thr 
             340                345                350
Thr Val Ile His Asn Pro Asp Gly Asn Lys Glu Ser Thr Glu Ser Ser 
         355                360                365
Asn Thr Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile 
     370                375                380
Ile Lys Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe 
 385                390                395                400
Glu Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro 
                 405                410                415
Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr 
             420                425                430
Phe Glu Asn Ala Leu Pro Lys Ile Asn Lys Pro Ile His Thr Ile Ile 
         435                440                445
Leu Asn Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala 
     450                455                460
Tyr Ile Arg Leu Thr Gln Tyr Met Asp Gly Asn Gly Met Pro Lys Thr 
 465                470                475                480
Met Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp 
                 485                490                495
Gln Asn Ile His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys 
             500                505                510
Pro Pro Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser 
         515                520                525
Leu Trp Gln Asn Ile 
     530



<210> 2907
<211> 499
<212> PRT
<213> Homo sapiens
<308> Q13557
<400> 2907

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
  1               5                  10                  15
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
             20                  25                  30
Lys Ile Pro Thr Gly Gln Gly Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
         115                120                125
Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
             180                185                190
Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
 305                310                315                320
Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr 
                 325                330                335
Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys 
             340                345                350
Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala 
         355                360                365
Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala 
     370                375                380
Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
 385                390                395                400
Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn 
                 405                410                415
Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile 
             420                425                430
Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln 
         435                440                445
Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
     450                455                460
Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys Pro Pro 
 465                470                475                480
Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser Leu Trp 
                 485                490                495
Gln Asn Ile 
             500



<210> 2908
<211> 558
<212> DNA
<213> Rattus norvegicus
<308> L13406
<400> 2908

ttttcagca  ccaagagtt  gttgaagaa  ccggatggg  taaaggagt  aactgagag  60
tcaaatacc  ccattgagg  tgaagacgt  aaagcacga  agcaagaga  catcaaagt  120
actgagcag  tgattgaag  tatcaacaa  ggggacttc  aggcttaca  gaaaatctg  180
gatccaggc  tcactgcct  tgaacccga  gcattgggc  acttagtgg  agggatgga  240
tttcacaga  tctactttg  aaatgcttt  cccaaaatc  ataaaccaa  ccacactat  300
atcctgaac  ctcacgtac  cctggtagg  gatgatgca  cctgcatag  atacattcg  360
ctcacacag  acatggatg  aaatggaat  ccaaagaca  tgcagtcag  agagactcg  420
gtgtggcac  gccgtgatg  gaagtggca  aatattcac  ttcatcgtt  ggggtcccc  480
acagtcccc  tcaagccac  ctgtattcc  aatgggaaa  aaaacttct  aggaggcac  540
tctttgtgg  aaaacatc  558



<210> 2909
<211> 533
<212> PRT
<213> Rattus norvegicus
<308> AAA41479
<400> 2909

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
  1               5                  10                  15
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
             20                  25                  30
Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
         115                120                125
Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
             180                185                190
Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
 305                310                315                320
Leu Lys Lys Pro Asp Gly Val Lys Ile Asn Asn Lys Ala Asn Val Val 
                 325                330                335
Thr Ser Pro Lys Glu Asn Ile Pro Thr Pro Ala Leu Glu Pro Gln Thr 
             340                345                350
Thr Val Ile His Asn Pro Asp Gly Asn Lys Glu Ser Thr Glu Ser Ser 
         355                360                365
Asn Thr Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile 
     370                375                380
Ile Lys Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe 
 385                390                395                400
Glu Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro 
                 405                410                415
Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr 
             420                425                430
Phe Glu Asn Ala Leu Pro Lys Ile Asn Lys Pro Ile His Thr Ile Ile 
         435                440                445
Leu Asn Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala 
     450                455                460
Tyr Ile Arg Leu Thr Gln Tyr Met Asp Gly Asn Gly Met Pro Lys Thr 
 465                470                475                480
Met Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp 
                 485                490                495
Gln Asn Ile His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys 
             500                505                510
Pro Pro Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser 
         515                520                525
Leu Trp Gln Asn Ile 
     530



<210> 2911
<211> 499
<212> PRT
<213> Homo sapiens
<308> Q13557
<400> 2911

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
  1               5                  10                  15
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
             20                  25                  30
Lys Ile Pro Thr Gly Gln Gly Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
         115                120                125
Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
             180                185                190
Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
 305                310                315                320
Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr 
                 325                330                335
Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys 
             340                345                350
Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala 
         355                360                365
Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala 
     370                375                380
Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
 385                390                395                400
Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn 
                 405                410                415
Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile 
             420                425                430
Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln 
         435                440                445
Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
     450                455                460
Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys Pro Pro 
 465                470                475                480
Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser Leu Trp 
                 485                490                495
Gln Asn Ile 
             500



<210> 2912
<211> 2410
<212> DNA
<213> Rattus norvegicus
<308> L13619
<400> 2912

tacgctgct  tggtggcgt  cacctctca  ggtgtgcct  gccgccgat  cccaggctg  60
acgatcacg  ctggagcta  ccaagcgcg  gcgctgcga  gccgtacag  ctcccgcga  120
gcatgattg  ggcggccct  tgtccgcag  gccccggag  ccccgagcc  gagcccgcg  180
cccggggcc  gcgagaggg  accgcaggc  tcagcgcac  acccggcag  tggcaccac  240
acctggtgc  gcggagcct  gtgctcttc  catttggcg  ggtcctggc  ctggtgctc  300
acctgctgc  gatccagcg  aatgtcacg  tcttcccgg  cgaggtgat  gccaccatc  360
tctcctccg  ctggtgggt  cccccgtgc  gtggcacgg  agccgctgt  gtcggctta  420
tgtatccct  tattgacag  cacctggga  aaccacaca  gttcaagag  gagtgggcc  480
gtgtcatgc  atgtatcgc  gtgtttgtt  gcatcaacc  tgccagtgc  aaattagat  540
tcgccaata  tgtgcagct  tccctgact  tggcagccc  atccttggg  ttgtggtgg  600
cgtttgatc  atcccgaag  ggcctgggg  tcgggatca  catcgcctt  ctagccacg  660
tgatcactc  gtttcttgt  tataatggc  tctaccagt  cacgtcccc  gatttcctc  720
atatccgtt  ttggctccc  tgtatattt  tctcaggag  tgtcacagt  ggaaacata  780
gacgacagt  agctatggg  gttccagaa  agcctcaca  tgactgagt  tgagcacat  840
attcagggc  gaagcagaa  gtggagaca  tggtcctgg  tgtggtgaa  aggatcttt  900
tctcaatgt  ccatttaga  tgggctgat  ataaatgac  cctaaagat  cgttcacgt  960
gtctaaata  caagtggag  caaggacta  ttacctaaa  tcttacctt  ctcacccac  1020
ctcacacct  tctgcactg  aacattcta  cccaggctg  atgtgagag  tgggtaagg  1080
ggccggttt  ccgagtatt  gatttcact  atcattcaa  gcaaaatgc  atatttcaa  1140
gccttgaat  aaaatgaat  accaactag  agttttata  cagtgccca  aggagagag  1200
ttgatggtg  ttaacagag  tgaagtatg  gcagtaaga  tatttatcc  gaattaaaa  1260
atagggttg  gtaaagagg  gctaagggc  gcagtaagt  ggaggaaga  catgctccc  1320
ggaggaccc  gtgcagcca  atctccagg  ctcgctcag  ctggcgctc  cacgtgggt  1380
tcatcagtg  gggaactat  ctgtttact  acaggaggc  tgtagacaa  cttactgac  1440
gcccaggac  acacaaagt  aggattctg  attgcgatg  tggactttt  atctcaatt  1500
aagtgaagt  ttatccaag  tctggagca  ctaagagtg  atagctgtc  gctgtttca  1560
tcgtaatga  ccgaaattg  gtctctgtc  ctccagagt  gagaggact  ttccacagc  1620
ctatggagc  tgcaatctg  gattgcctt  taaaaggtt  agtgtgcac  tcactgcgt  1680
cggtgcgca  tgtcctgtg  gtgttggac  gcgtagaac  catgggacc  tgcaagtat  1740
gggtcttca  cttcaagtg  aatgtgtat  aaaccaatc  gagccttgt  ttctcttaa  1800
tatttatta  tttttttta  ccgcgcgag  tgttctgga  aagggttct  gggtcattt  1860
agagctgtg  gaggcacac  cagcaatac  gtgtcagcc  tgacgctcc  cagtcacac  1920
ctccactac  ccctagtcc  ttgacatac  ccaggtttg  aagtttagt  atttttact  1980
acaaattta  ccttttttg  attctaaaa  tgtgtttaa  ttatatgga  gtacttggt  2040
taggcagtc  ttggtcccc  ggcagcaga  gctctgcct  tggaatcgg  tttgggttc  2100
ctctgcagg  ctcctcata  aggctttgc  tatttgttt  gaggaaaat  tctggagta  2160
acctttgtt  tctgaaact  ctttagcta  aagaaaatg  gtgttctag  ctttggaat  2220
gttcttaaa  tttcctgga  ataaaaata  tgattggca  ttcaaagac  ttctttagc  2280
aagacttca  tgtctagca  aaaccacaa  tgactagaa  agcaagtga  cttggtgat  2340
cacttgatt  tatacaatg  gtatttttt  tcttaaact  gaaataaat  tgttagaaa  2400
aatatagcca  2410



<210> 2913
<211> 259
<212> PRT
<213> Rattus norvegicus
<308> Q08755
<400> 2913

Met Pro Arg Leu His Asp His Val Trp Ser Tyr Pro Ser Ala Gly Ala 
  1               5                  10                  15
Ala Arg Pro Tyr Ser Leu Pro Arg Gly Met Ile Ala Ala Ala Leu Cys 
             20                  25                  30
Pro Gln Gly Pro Gly Ala Pro Glu Pro Glu Pro Ala Pro Arg Gly Gln 
         35                  40                  45
Arg Glu Gly Thr Ala Gly Phe Ser Ala Arg Pro Gly Ser Trp His His 
     50                  55                  60
Asp Leu Val Gln Arg Ser Leu Val Leu Phe Ser Phe Gly Val Val Leu 
 65                  70                  75                  80
Ala Leu Val Leu Asn Leu Leu Gln Ile Gln Arg Asn Val Thr Leu Phe 
                 85                  90                  95
Pro Asp Glu Val Ile Ala Thr Ile Phe Ser Ser Ala Trp Trp Val Pro 
             100                105                110
Pro Cys Cys Gly Thr Ala Ala Ala Val Val Gly Leu Leu Tyr Pro Cys 
         115                120                125
Ile Asp Ser His Leu Gly Glu Pro His Lys Phe Lys Arg Glu Trp Ala 
     130                135                140
Ser Val Met Arg Cys Ile Ala Val Phe Val Gly Ile Asn His Ala Ser 
 145                150                155                160
Ala Lys Leu Asp Phe Ala Asn Asn Val Gln Leu Ser Leu Thr Leu Ala 
                 165                170                175
Ala Leu Ser Leu Gly Leu Trp Trp Thr Phe Asp Arg Ser Arg Ser Gly 
             180                185                190
Leu Gly Leu Gly Ile Thr Ile Ala Phe Leu Ala Thr Leu Ile Thr Gln 
         195                200                205
Phe Leu Val Tyr Asn Gly Val Tyr Gln Tyr Thr Ser Pro Asp Phe Leu 
     210                215                220
Tyr Ile Arg Ser Trp Leu Pro Cys Ile Phe Phe Ser Gly Gly Val Thr 
 225                230                235                240
Val Gly Asn Ile Gly Arg Gln Leu Ala Met Gly Val Pro Glu Lys Pro 
                 245                250                255
His Ser Asp 
             260



<210> 2914
<211> 1469
<212> DNA
<213> Homo sapiens
<308> BC001880
<400> 2914

ccgcggccc  ccatataaa  ccgcgcgcc  gccaggcgc  gcggccgtc  cgggccgtg  60
ctcctcctt  cccccgccc  gcctccgtt  ggagagccg  cgggcgggc  cctctcggc  120
aggaagcgc  tcttggacg  gtgtgaccg  tgcccagat  gcacgacca  ttctggagc  180
gctcctgtg  gcacagcgc  aggcgccga  gccccccgc  agccagcgc  gcggggctg  240
cggccaagg  tggggagat  atcaacgtt  ccgtgtccg  gccctccct  ctggcggcc  300
acggtgccc  ggacgctga  cccgcgccc  ggggccgca  tgctgcgat  agcggcccc  360
agcccggca  cccctaccc  aacacctgg  atcatcgcc  gttgcagag  agcctcgtg  420
tcttctcgg  tggggtggt  ctagccctg  tgctcaacc  gctgcagat  cagaggaat  480
tcactctct  ccccgagga  gtgatcgcc  ccatctttt  ctccgcctg  tgggtccct  540
cctgctgcg  gacagcagc  gctgttgtt  gcctactgt  cccctgtat  gacagtcac  600
tcggagaac  ccacaaatt  aagagagaa  gggccagtg  catgcgctg  atagcagtt  660
ttgttggca  taaccacgc  agtgctaaa  tggattttg  caataatgt  cagctgtcc  720
tgactttag  agccctatc  ttgggcctt  ggtggacat  tgatcgttc  agaagtggc  780
ttgggctgg  gatcaccat  gcttttcta  ctacgctga  cacgcagtt  ctcgtgtat  840
atggtgtct  tcagtatac  tccccagat  tcctctata  tcgttcttg  ctcccttgt  900
tatttttct  aggaggcgt  acggtgggg  acataggac  acagttagc  atgggtgtt  960
ctgaaaagc  ccatagtga  tgagtcttc  aaaccaccg  ttctgagag  aaggaagat  1020
ttggaagaa  atctgactg  ggattatga  aaagattat  ttttttctt  agtaatcta  1080
ttagatcgg  ctgactgta  aaatgactc  tggaaaaaa  tcttcacct  gtctagaat  1140
gggaggtgg  gaatgatga  ttaccctga  gtcttccct  gactgcccg  actggcgcc  1200
gtctgtgcc  tggagcatt  tgcccaggc  acgtgggtt  aggcaggtg  cagcttccc  1260
agtattcga  ttcattcat  tgattaaaa  aagttgcca  atttcaaag  cttgaacta  1320
gactcaatt  ccaacccgc  gttttgtgt  agtgcccaa  ggaggtagg  tgatggtgc  1380
taacaaaca  gaagtatgg  gtaatagga  taatattta  ccaaaagat  tttaaaaat  1440
gggctgtgt  taaaaaaaa  aaaaaaaaa  1469



<210> 2915
<211> 277
<212> PRT
<213> Homo sapiens
<308> O15503
<400> 2915

Met Pro Arg Leu His Asp His Phe Trp Ser Cys Ser Cys Ala His Ser 
  1               5                  10                  15
Ala Arg Arg Arg Gly Pro Pro Arg Ala Ser Thr Ala Gly Leu Pro Pro 
             20                  25                  30
Lys Val Gly Glu Met Ile Asn Val Ser Val Ser Gly Pro Ser Leu Leu 
         35                  40                  45
Ala Ala His Gly Ala Pro Asp Ala Asp Pro Ala Pro Arg Gly Arg Ser 
     50                  55                  60
Ala Ala Met Ser Gly Pro Glu Pro Gly Ser Pro Tyr Pro Asn Thr Trp 
 65                  70                  75                  80
His His Arg Leu Leu Gln Arg Ser Leu Val Leu Phe Ser Val Gly Val 
                 85                  90                  95
Val Leu Ala Leu Val Leu Asn Leu Leu Gln Ile Gln Arg Asn Val Thr 
             100                105                110
Leu Phe Pro Glu Glu Val Ile Ala Thr Ile Phe Ser Ser Ala Trp Trp 
         115                120                125
Val Pro Pro Cys Cys Gly Thr Ala Ala Ala Val Val Gly Leu Leu Tyr 
     130                135                140
Pro Cys Ile Asp Ser His Leu Gly Glu Pro His Lys Phe Lys Arg Glu 
 145                150                155                160
Trp Ala Ser Val Met Arg Cys Ile Ala Val Phe Val Gly Ile Asn His 
                 165                170                175
Ala Ser Ala Lys Leu Asp Phe Ala Asn Asn Val Gln Leu Ser Leu Thr 
             180                185                190
Leu Ala Ala Leu Ser Leu Gly Leu Trp Trp Thr Phe Asp Arg Ser Arg 
         195                200                205
Ser Gly Leu Gly Leu Gly Ile Thr Ile Ala Phe Leu Ala Thr Leu Ile 
     210                215                220
Thr Gln Phe Leu Val Tyr Asn Gly Val Tyr Gln Tyr Thr Ser Pro Asp 
 225                230                235                240
Phe Leu Tyr Ile Arg Ser Trp Leu Pro Cys Ile Phe Phe Ser Gly Gly 
                 245                250                255
Val Thr Val Gly Asn Ile Gly Arg Gln Leu Ala Met Gly Val Pro Glu 
             260                265                270
Lys Pro His Ser Asp 
         275



<210> 2916
<211> 2410
<212> DNA
<213> Rattus norvegicus
<308> L13619
<400> 2916

tacgctgct  tggtggcgt  cacctctca  ggtgtgcct  gccgccgat  cccaggctg  60
acgatcacg  ctggagcta  ccaagcgcg  gcgctgcga  gccgtacag  ctcccgcga  120
gcatgattg  ggcggccct  tgtccgcag  gccccggag  ccccgagcc  gagcccgcg  180
cccggggcc  gcgagaggg  accgcaggc  tcagcgcac  acccggcag  tggcaccac  240
acctggtgc  gcggagcct  gtgctcttc  catttggcg  ggtcctggc  ctggtgctc  300
acctgctgc  gatccagcg  aatgtcacg  tcttcccgg  cgaggtgat  gccaccatc  360
tctcctccg  ctggtgggt  cccccgtgc  gtggcacgg  agccgctgt  gtcggctta  420
tgtatccct  tattgacag  cacctggga  aaccacaca  gttcaagag  gagtgggcc  480
gtgtcatgc  atgtatcgc  gtgtttgtt  gcatcaacc  tgccagtgc  aaattagat  540
tcgccaata  tgtgcagct  tccctgact  tggcagccc  atccttggg  ttgtggtgg  600
cgtttgatc  atcccgaag  ggcctgggg  tcgggatca  catcgcctt  ctagccacg  660
tgatcactc  gtttcttgt  tataatggc  tctaccagt  cacgtcccc  gatttcctc  720
atatccgtt  ttggctccc  tgtatattt  tctcaggag  tgtcacagt  ggaaacata  780
gacgacagt  agctatggg  gttccagaa  agcctcaca  tgactgagt  tgagcacat  840
attcagggc  gaagcagaa  gtggagaca  tggtcctgg  tgtggtgaa  aggatcttt  900
tctcaatgt  ccatttaga  tgggctgat  ataaatgac  cctaaagat  cgttcacgt  960
gtctaaata  caagtggag  caaggacta  ttacctaaa  tcttacctt  ctcacccac  1020
ctcacacct  tctgcactg  aacattcta  cccaggctg  atgtgagag  tgggtaagg  1080
ggccggttt  ccgagtatt  gatttcact  atcattcaa  gcaaaatgc  atatttcaa  1140
gccttgaat  aaaatgaat  accaactag  agttttata  cagtgccca  aggagagag  1200
ttgatggtg  ttaacagag  tgaagtatg  gcagtaaga  tatttatcc  gaattaaaa  1260
atagggttg  gtaaagagg  gctaagggc  gcagtaagt  ggaggaaga  catgctccc  1320
ggaggaccc  gtgcagcca  atctccagg  ctcgctcag  ctggcgctc  cacgtgggt  1380
tcatcagtg  gggaactat  ctgtttact  acaggaggc  tgtagacaa  cttactgac  1440
gcccaggac  acacaaagt  aggattctg  attgcgatg  tggactttt  atctcaatt  1500
aagtgaagt  ttatccaag  tctggagca  ctaagagtg  atagctgtc  gctgtttca  1560
tcgtaatga  ccgaaattg  gtctctgtc  ctccagagt  gagaggact  ttccacagc  1620
ctatggagc  tgcaatctg  gattgcctt  taaaaggtt  agtgtgcac  tcactgcgt  1680
cggtgcgca  tgtcctgtg  gtgttggac  gcgtagaac  catgggacc  tgcaagtat  1740
gggtcttca  cttcaagtg  aatgtgtat  aaaccaatc  gagccttgt  ttctcttaa  1800
tatttatta  tttttttta  ccgcgcgag  tgttctgga  aagggttct  gggtcattt  1860
agagctgtg  gaggcacac  cagcaatac  gtgtcagcc  tgacgctcc  cagtcacac  1920
ctccactac  ccctagtcc  ttgacatac  ccaggtttg  aagtttagt  atttttact  1980
acaaattta  ccttttttg  attctaaaa  tgtgtttaa  ttatatgga  gtacttggt  2040
taggcagtc  ttggtcccc  ggcagcaga  gctctgcct  tggaatcgg  tttgggttc  2100
ctctgcagg  ctcctcata  aggctttgc  tatttgttt  gaggaaaat  tctggagta  2160
acctttgtt  tctgaaact  ctttagcta  aagaaaatg  gtgttctag  ctttggaat  2220
gttcttaaa  tttcctgga  ataaaaata  tgattggca  ttcaaagac  ttctttagc  2280
aagacttca  tgtctagca  aaaccacaa  tgactagaa  agcaagtga  cttggtgat  2340
cacttgatt  tatacaatg  gtatttttt  tcttaaact  gaaataaat  tgttagaaa  2400
aatatagcca  2410



<210> 2917
<211> 259
<212> PRT
<213> Rattus norvegicus
<308> Q08755
<400> 2917

Met Pro Arg Leu His Asp His Val Trp Ser Tyr Pro Ser Ala Gly Ala 
  1               5                  10                  15
Ala Arg Pro Tyr Ser Leu Pro Arg Gly Met Ile Ala Ala Ala Leu Cys 
             20                  25                  30
Pro Gln Gly Pro Gly Ala Pro Glu Pro Glu Pro Ala Pro Arg Gly Gln 
         35                  40                  45
Arg Glu Gly Thr Ala Gly Phe Ser Ala Arg Pro Gly Ser Trp His His 
     50                  55                  60
Asp Leu Val Gln Arg Ser Leu Val Leu Phe Ser Phe Gly Val Val Leu 
 65                  70                  75                  80
Ala Leu Val Leu Asn Leu Leu Gln Ile Gln Arg Asn Val Thr Leu Phe 
                 85                  90                  95
Pro Asp Glu Val Ile Ala Thr Ile Phe Ser Ser Ala Trp Trp Val Pro 
             100                105                110
Pro Cys Cys Gly Thr Ala Ala Ala Val Val Gly Leu Leu Tyr Pro Cys 
         115                120                125
Ile Asp Ser His Leu Gly Glu Pro His Lys Phe Lys Arg Glu Trp Ala 
     130                135                140
Ser Val Met Arg Cys Ile Ala Val Phe Val Gly Ile Asn His Ala Ser 
 145                150                155                160
Ala Lys Leu Asp Phe Ala Asn Asn Val Gln Leu Ser Leu Thr Leu Ala 
                 165                170                175
Ala Leu Ser Leu Gly Leu Trp Trp Thr Phe Asp Arg Ser Arg Ser Gly 
             180                185                190
Leu Gly Leu Gly Ile Thr Ile Ala Phe Leu Ala Thr Leu Ile Thr Gln 
         195                200                205
Phe Leu Val Tyr Asn Gly Val Tyr Gln Tyr Thr Ser Pro Asp Phe Leu 
     210                215                220
Tyr Ile Arg Ser Trp Leu Pro Cys Ile Phe Phe Ser Gly Gly Val Thr 
 225                230                235                240
Val Gly Asn Ile Gly Arg Gln Leu Ala Met Gly Val Pro Glu Lys Pro 
                 245                250                255
His Ser Asp 
             260



<210> 2918
<211> 1469
<212> DNA
<213> Homo sapiens
<308> BC001880
<400> 2918

ccgcggccc  ccatataaa  ccgcgcgcc  gccaggcgc  gcggccgtc  cgggccgtg  60
ctcctcctt  cccccgccc  gcctccgtt  ggagagccg  cgggcgggc  cctctcggc  120
aggaagcgc  tcttggacg  gtgtgaccg  tgcccagat  gcacgacca  ttctggagc  180
gctcctgtg  gcacagcgc  aggcgccga  gccccccgc  agccagcgc  gcggggctg  240
cggccaagg  tggggagat  atcaacgtt  ccgtgtccg  gccctccct  ctggcggcc  300
acggtgccc  ggacgctga  cccgcgccc  ggggccgca  tgctgcgat  agcggcccc  360
agcccggca  cccctaccc  aacacctgg  atcatcgcc  gttgcagag  agcctcgtg  420
tcttctcgg  tggggtggt  ctagccctg  tgctcaacc  gctgcagat  cagaggaat  480
tcactctct  ccccgagga  gtgatcgcc  ccatctttt  ctccgcctg  tgggtccct  540
cctgctgcg  gacagcagc  gctgttgtt  gcctactgt  cccctgtat  gacagtcac  600
tcggagaac  ccacaaatt  aagagagaa  gggccagtg  catgcgctg  atagcagtt  660
ttgttggca  taaccacgc  agtgctaaa  tggattttg  caataatgt  cagctgtcc  720
tgactttag  agccctatc  ttgggcctt  ggtggacat  tgatcgttc  agaagtggc  780
ttgggctgg  gatcaccat  gcttttcta  ctacgctga  cacgcagtt  ctcgtgtat  840
atggtgtct  tcagtatac  tccccagat  tcctctata  tcgttcttg  ctcccttgt  900
tatttttct  aggaggcgt  acggtgggg  acataggac  acagttagc  atgggtgtt  960
ctgaaaagc  ccatagtga  tgagtcttc  aaaccaccg  ttctgagag  aaggaagat  1020
ttggaagaa  atctgactg  ggattatga  aaagattat  ttttttctt  agtaatcta  1080
ttagatcgg  ctgactgta  aaatgactc  tggaaaaaa  tcttcacct  gtctagaat  1140
gggaggtgg  gaatgatga  ttaccctga  gtcttccct  gactgcccg  actggcgcc  1200
gtctgtgcc  tggagcatt  tgcccaggc  acgtgggtt  aggcaggtg  cagcttccc  1260
agtattcga  ttcattcat  tgattaaaa  aagttgcca  atttcaaag  cttgaacta  1320
gactcaatt  ccaacccgc  gttttgtgt  agtgcccaa  ggaggtagg  tgatggtgc  1380
taacaaaca  gaagtatgg  gtaatagga  taatattta  ccaaaagat  tttaaaaat  1440
gggctgtgt  taaaaaaaa  aaaaaaaaa  1469



<210> 2919
<211> 277
<212> PRT
<213> Homo sapiens
<308> O15503
<400> 2919

Met Pro Arg Leu His Asp His Phe Trp Ser Cys Ser Cys Ala His Ser 
  1               5                  10                  15
Ala Arg Arg Arg Gly Pro Pro Arg Ala Ser Thr Ala Gly Leu Pro Pro 
             20                  25                  30
Lys Val Gly Glu Met Ile Asn Val Ser Val Ser Gly Pro Ser Leu Leu 
         35                  40                  45
Ala Ala His Gly Ala Pro Asp Ala Asp Pro Ala Pro Arg Gly Arg Ser 
     50                  55                  60
Ala Ala Met Ser Gly Pro Glu Pro Gly Ser Pro Tyr Pro Asn Thr Trp 
 65                  70                  75                  80
His His Arg Leu Leu Gln Arg Ser Leu Val Leu Phe Ser Val Gly Val 
                 85                  90                  95
Val Leu Ala Leu Val Leu Asn Leu Leu Gln Ile Gln Arg Asn Val Thr 
             100                105                110
Leu Phe Pro Glu Glu Val Ile Ala Thr Ile Phe Ser Ser Ala Trp Trp 
         115                120                125
Val Pro Pro Cys Cys Gly Thr Ala Ala Ala Val Val Gly Leu Leu Tyr 
     130                135                140
Pro Cys Ile Asp Ser His Leu Gly Glu Pro His Lys Phe Lys Arg Glu 
 145                150                155                160
Trp Ala Ser Val Met Arg Cys Ile Ala Val Phe Val Gly Ile Asn His 
                 165                170                175
Ala Ser Ala Lys Leu Asp Phe Ala Asn Asn Val Gln Leu Ser Leu Thr 
             180                185                190
Leu Ala Ala Leu Ser Leu Gly Leu Trp Trp Thr Phe Asp Arg Ser Arg 
         195                200                205
Ser Gly Leu Gly Leu Gly Ile Thr Ile Ala Phe Leu Ala Thr Leu Ile 
     210                215                220
Thr Gln Phe Leu Val Tyr Asn Gly Val Tyr Gln Tyr Thr Ser Pro Asp 
 225                230                235                240
Phe Leu Tyr Ile Arg Ser Trp Leu Pro Cys Ile Phe Phe Ser Gly Gly 
                 245                250                255
Val Thr Val Gly Asn Ile Gly Arg Gln Leu Ala Met Gly Val Pro Glu 
             260                265                270
Lys Pro His Ser Asp 
         275



<210> 2920
<211> 2410
<212> DNA
<213> Rattus norvegicus
<308> L13619
<400> 2920

tacgctgct  tggtggcgt  cacctctca  ggtgtgcct  gccgccgat  cccaggctg  60
acgatcacg  ctggagcta  ccaagcgcg  gcgctgcga  gccgtacag  ctcccgcga  120
gcatgattg  ggcggccct  tgtccgcag  gccccggag  ccccgagcc  gagcccgcg  180
cccggggcc  gcgagaggg  accgcaggc  tcagcgcac  acccggcag  tggcaccac  240
acctggtgc  gcggagcct  gtgctcttc  catttggcg  ggtcctggc  ctggtgctc  300
acctgctgc  gatccagcg  aatgtcacg  tcttcccgg  cgaggtgat  gccaccatc  360
tctcctccg  ctggtgggt  cccccgtgc  gtggcacgg  agccgctgt  gtcggctta  420
tgtatccct  tattgacag  cacctggga  aaccacaca  gttcaagag  gagtgggcc  480
gtgtcatgc  atgtatcgc  gtgtttgtt  gcatcaacc  tgccagtgc  aaattagat  540
tcgccaata  tgtgcagct  tccctgact  tggcagccc  atccttggg  ttgtggtgg  600
cgtttgatc  atcccgaag  ggcctgggg  tcgggatca  catcgcctt  ctagccacg  660
tgatcactc  gtttcttgt  tataatggc  tctaccagt  cacgtcccc  gatttcctc  720
atatccgtt  ttggctccc  tgtatattt  tctcaggag  tgtcacagt  ggaaacata  780
gacgacagt  agctatggg  gttccagaa  agcctcaca  tgactgagt  tgagcacat  840
attcagggc  gaagcagaa  gtggagaca  tggtcctgg  tgtggtgaa  aggatcttt  900
tctcaatgt  ccatttaga  tgggctgat  ataaatgac  cctaaagat  cgttcacgt  960
gtctaaata  caagtggag  caaggacta  ttacctaaa  tcttacctt  ctcacccac  1020
ctcacacct  tctgcactg  aacattcta  cccaggctg  atgtgagag  tgggtaagg  1080
ggccggttt  ccgagtatt  gatttcact  atcattcaa  gcaaaatgc  atatttcaa  1140
gccttgaat  aaaatgaat  accaactag  agttttata  cagtgccca  aggagagag  1200
ttgatggtg  ttaacagag  tgaagtatg  gcagtaaga  tatttatcc  gaattaaaa  1260
atagggttg  gtaaagagg  gctaagggc  gcagtaagt  ggaggaaga  catgctccc  1320
ggaggaccc  gtgcagcca  atctccagg  ctcgctcag  ctggcgctc  cacgtgggt  1380
tcatcagtg  gggaactat  ctgtttact  acaggaggc  tgtagacaa  cttactgac  1440
gcccaggac  acacaaagt  aggattctg  attgcgatg  tggactttt  atctcaatt  1500
aagtgaagt  ttatccaag  tctggagca  ctaagagtg  atagctgtc  gctgtttca  1560
tcgtaatga  ccgaaattg  gtctctgtc  ctccagagt  gagaggact  ttccacagc  1620
ctatggagc  tgcaatctg  gattgcctt  taaaaggtt  agtgtgcac  tcactgcgt  1680
cggtgcgca  tgtcctgtg  gtgttggac  gcgtagaac  catgggacc  tgcaagtat  1740
gggtcttca  cttcaagtg  aatgtgtat  aaaccaatc  gagccttgt  ttctcttaa  1800
tatttatta  tttttttta  ccgcgcgag  tgttctgga  aagggttct  gggtcattt  1860
agagctgtg  gaggcacac  cagcaatac  gtgtcagcc  tgacgctcc  cagtcacac  1920
ctccactac  ccctagtcc  ttgacatac  ccaggtttg  aagtttagt  atttttact  1980
acaaattta  ccttttttg  attctaaaa  tgtgtttaa  ttatatgga  gtacttggt  2040
taggcagtc  ttggtcccc  ggcagcaga  gctctgcct  tggaatcgg  tttgggttc  2100
ctctgcagg  ctcctcata  aggctttgc  tatttgttt  gaggaaaat  tctggagta  2160
acctttgtt  tctgaaact  ctttagcta  aagaaaatg  gtgttctag  ctttggaat  2220
gttcttaaa  tttcctgga  ataaaaata  tgattggca  ttcaaagac  ttctttagc  2280
aagacttca  tgtctagca  aaaccacaa  tgactagaa  agcaagtga  cttggtgat  2340
cacttgatt  tatacaatg  gtatttttt  tcttaaact  gaaataaat  tgttagaaa  2400
aatatagcca  2410



<210> 2921
<211> 259
<212> PRT
<213> Rattus norvegicus
<308> Q08755
<400> 2921

Met Pro Arg Leu His Asp His Val Trp Ser Tyr Pro Ser Ala Gly Ala 
  1               5                  10                  15
Ala Arg Pro Tyr Ser Leu Pro Arg Gly Met Ile Ala Ala Ala Leu Cys 
             20                  25                  30
Pro Gln Gly Pro Gly Ala Pro Glu Pro Glu Pro Ala Pro Arg Gly Gln 
         35                  40                  45
Arg Glu Gly Thr Ala Gly Phe Ser Ala Arg Pro Gly Ser Trp His His 
     50                  55                  60
Asp Leu Val Gln Arg Ser Leu Val Leu Phe Ser Phe Gly Val Val Leu 
 65                  70                  75                  80
Ala Leu Val Leu Asn Leu Leu Gln Ile Gln Arg Asn Val Thr Leu Phe 
                 85                  90                  95
Pro Asp Glu Val Ile Ala Thr Ile Phe Ser Ser Ala Trp Trp Val Pro 
             100                105                110
Pro Cys Cys Gly Thr Ala Ala Ala Val Val Gly Leu Leu Tyr Pro Cys 
         115                120                125
Ile Asp Ser His Leu Gly Glu Pro His Lys Phe Lys Arg Glu Trp Ala 
     130                135                140
Ser Val Met Arg Cys Ile Ala Val Phe Val Gly Ile Asn His Ala Ser 
 145                150                155                160
Ala Lys Leu Asp Phe Ala Asn Asn Val Gln Leu Ser Leu Thr Leu Ala 
                 165                170                175
Ala Leu Ser Leu Gly Leu Trp Trp Thr Phe Asp Arg Ser Arg Ser Gly 
             180                185                190
Leu Gly Leu Gly Ile Thr Ile Ala Phe Leu Ala Thr Leu Ile Thr Gln 
         195                200                205
Phe Leu Val Tyr Asn Gly Val Tyr Gln Tyr Thr Ser Pro Asp Phe Leu 
     210                215                220
Tyr Ile Arg Ser Trp Leu Pro Cys Ile Phe Phe Ser Gly Gly Val Thr 
 225                230                235                240
Val Gly Asn Ile Gly Arg Gln Leu Ala Met Gly Val Pro Glu Lys Pro 
                 245                250                255
His Ser Asp 
             260



<210> 2922
<211> 1469
<212> DNA
<213> Homo sapiens
<308> BC001880
<400> 2922

ccgcggccc  ccatataaa  ccgcgcgcc  gccaggcgc  gcggccgtc  cgggccgtg  60
ctcctcctt  cccccgccc  gcctccgtt  ggagagccg  cgggcgggc  cctctcggc  120
aggaagcgc  tcttggacg  gtgtgaccg  tgcccagat  gcacgacca  ttctggagc  180
gctcctgtg  gcacagcgc  aggcgccga  gccccccgc  agccagcgc  gcggggctg  240
cggccaagg  tggggagat  atcaacgtt  ccgtgtccg  gccctccct  ctggcggcc  300
acggtgccc  ggacgctga  cccgcgccc  ggggccgca  tgctgcgat  agcggcccc  360
agcccggca  cccctaccc  aacacctgg  atcatcgcc  gttgcagag  agcctcgtg  420
tcttctcgg  tggggtggt  ctagccctg  tgctcaacc  gctgcagat  cagaggaat  480
tcactctct  ccccgagga  gtgatcgcc  ccatctttt  ctccgcctg  tgggtccct  540
cctgctgcg  gacagcagc  gctgttgtt  gcctactgt  cccctgtat  gacagtcac  600
tcggagaac  ccacaaatt  aagagagaa  gggccagtg  catgcgctg  atagcagtt  660
ttgttggca  taaccacgc  agtgctaaa  tggattttg  caataatgt  cagctgtcc  720
tgactttag  agccctatc  ttgggcctt  ggtggacat  tgatcgttc  agaagtggc  780
ttgggctgg  gatcaccat  gcttttcta  ctacgctga  cacgcagtt  ctcgtgtat  840
atggtgtct  tcagtatac  tccccagat  tcctctata  tcgttcttg  ctcccttgt  900
tatttttct  aggaggcgt  acggtgggg  acataggac  acagttagc  atgggtgtt  960
ctgaaaagc  ccatagtga  tgagtcttc  aaaccaccg  ttctgagag  aaggaagat  1020
ttggaagaa  atctgactg  ggattatga  aaagattat  ttttttctt  agtaatcta  1080
ttagatcgg  ctgactgta  aaatgactc  tggaaaaaa  tcttcacct  gtctagaat  1140
gggaggtgg  gaatgatga  ttaccctga  gtcttccct  gactgcccg  actggcgcc  1200
gtctgtgcc  tggagcatt  tgcccaggc  acgtgggtt  aggcaggtg  cagcttccc  1260
agtattcga  ttcattcat  tgattaaaa  aagttgcca  atttcaaag  cttgaacta  1320
gactcaatt  ccaacccgc  gttttgtgt  agtgcccaa  ggaggtagg  tgatggtgc  1380
taacaaaca  gaagtatgg  gtaatagga  taatattta  ccaaaagat  tttaaaaat  1440
gggctgtgt  taaaaaaaa  aaaaaaaaa  1469



<210> 2923
<211> 277
<212> PRT
<213> Homo sapiens
<308> O15503
<400> 2923

Met Pro Arg Leu His Asp His Phe Trp Ser Cys Ser Cys Ala His Ser 
  1               5                  10                  15
Ala Arg Arg Arg Gly Pro Pro Arg Ala Ser Thr Ala Gly Leu Pro Pro 
             20                  25                  30
Lys Val Gly Glu Met Ile Asn Val Ser Val Ser Gly Pro Ser Leu Leu 
         35                  40                  45
Ala Ala His Gly Ala Pro Asp Ala Asp Pro Ala Pro Arg Gly Arg Ser 
     50                  55                  60
Ala Ala Met Ser Gly Pro Glu Pro Gly Ser Pro Tyr Pro Asn Thr Trp 
 65                  70                  75                  80
His His Arg Leu Leu Gln Arg Ser Leu Val Leu Phe Ser Val Gly Val 
                 85                  90                  95
Val Leu Ala Leu Val Leu Asn Leu Leu Gln Ile Gln Arg Asn Val Thr 
             100                105                110
Leu Phe Pro Glu Glu Val Ile Ala Thr Ile Phe Ser Ser Ala Trp Trp 
         115                120                125
Val Pro Pro Cys Cys Gly Thr Ala Ala Ala Val Val Gly Leu Leu Tyr 
     130                135                140
Pro Cys Ile Asp Ser His Leu Gly Glu Pro His Lys Phe Lys Arg Glu 
 145                150                155                160
Trp Ala Ser Val Met Arg Cys Ile Ala Val Phe Val Gly Ile Asn His 
                 165                170                175
Ala Ser Ala Lys Leu Asp Phe Ala Asn Asn Val Gln Leu Ser Leu Thr 
             180                185                190
Leu Ala Ala Leu Ser Leu Gly Leu Trp Trp Thr Phe Asp Arg Ser Arg 
         195                200                205
Ser Gly Leu Gly Leu Gly Ile Thr Ile Ala Phe Leu Ala Thr Leu Ile 
     210                215                220
Thr Gln Phe Leu Val Tyr Asn Gly Val Tyr Gln Tyr Thr Ser Pro Asp 
 225                230                235                240
Phe Leu Tyr Ile Arg Ser Trp Leu Pro Cys Ile Phe Phe Ser Gly Gly 
                 245                250                255
Val Thr Val Gly Asn Ile Gly Arg Gln Leu Ala Met Gly Val Pro Glu 
             260                265                270
Lys Pro His Ser Asp 
         275



<210> 2924
<211> 2410
<212> DNA
<213> Rattus norvegicus
<308> L13619
<400> 2924

tacgctgct  tggtggcgt  cacctctca  ggtgtgcct  gccgccgat  cccaggctg  60
acgatcacg  ctggagcta  ccaagcgcg  gcgctgcga  gccgtacag  ctcccgcga  120
gcatgattg  ggcggccct  tgtccgcag  gccccggag  ccccgagcc  gagcccgcg  180
cccggggcc  gcgagaggg  accgcaggc  tcagcgcac  acccggcag  tggcaccac  240
acctggtgc  gcggagcct  gtgctcttc  catttggcg  ggtcctggc  ctggtgctc  300
acctgctgc  gatccagcg  aatgtcacg  tcttcccgg  cgaggtgat  gccaccatc  360
tctcctccg  ctggtgggt  cccccgtgc  gtggcacgg  agccgctgt  gtcggctta  420
tgtatccct  tattgacag  cacctggga  aaccacaca  gttcaagag  gagtgggcc  480
gtgtcatgc  atgtatcgc  gtgtttgtt  gcatcaacc  tgccagtgc  aaattagat  540
tcgccaata  tgtgcagct  tccctgact  tggcagccc  atccttggg  ttgtggtgg  600
cgtttgatc  atcccgaag  ggcctgggg  tcgggatca  catcgcctt  ctagccacg  660
tgatcactc  gtttcttgt  tataatggc  tctaccagt  cacgtcccc  gatttcctc  720
atatccgtt  ttggctccc  tgtatattt  tctcaggag  tgtcacagt  ggaaacata  780
gacgacagt  agctatggg  gttccagaa  agcctcaca  tgactgagt  tgagcacat  840
attcagggc  gaagcagaa  gtggagaca  tggtcctgg  tgtggtgaa  aggatcttt  900
tctcaatgt  ccatttaga  tgggctgat  ataaatgac  cctaaagat  cgttcacgt  960
gtctaaata  caagtggag  caaggacta  ttacctaaa  tcttacctt  ctcacccac  1020
ctcacacct  tctgcactg  aacattcta  cccaggctg  atgtgagag  tgggtaagg  1080
ggccggttt  ccgagtatt  gatttcact  atcattcaa  gcaaaatgc  atatttcaa  1140
gccttgaat  aaaatgaat  accaactag  agttttata  cagtgccca  aggagagag  1200
ttgatggtg  ttaacagag  tgaagtatg  gcagtaaga  tatttatcc  gaattaaaa  1260
atagggttg  gtaaagagg  gctaagggc  gcagtaagt  ggaggaaga  catgctccc  1320
ggaggaccc  gtgcagcca  atctccagg  ctcgctcag  ctggcgctc  cacgtgggt  1380
tcatcagtg  gggaactat  ctgtttact  acaggaggc  tgtagacaa  cttactgac  1440
gcccaggac  acacaaagt  aggattctg  attgcgatg  tggactttt  atctcaatt  1500
aagtgaagt  ttatccaag  tctggagca  ctaagagtg  atagctgtc  gctgtttca  1560
tcgtaatga  ccgaaattg  gtctctgtc  ctccagagt  gagaggact  ttccacagc  1620
ctatggagc  tgcaatctg  gattgcctt  taaaaggtt  agtgtgcac  tcactgcgt  1680
cggtgcgca  tgtcctgtg  gtgttggac  gcgtagaac  catgggacc  tgcaagtat  1740
gggtcttca  cttcaagtg  aatgtgtat  aaaccaatc  gagccttgt  ttctcttaa  1800
tatttatta  tttttttta  ccgcgcgag  tgttctgga  aagggttct  gggtcattt  1860
agagctgtg  gaggcacac  cagcaatac  gtgtcagcc  tgacgctcc  cagtcacac  1920
ctccactac  ccctagtcc  ttgacatac  ccaggtttg  aagtttagt  atttttact  1980
acaaattta  ccttttttg  attctaaaa  tgtgtttaa  ttatatgga  gtacttggt  2040
taggcagtc  ttggtcccc  ggcagcaga  gctctgcct  tggaatcgg  tttgggttc  2100
ctctgcagg  ctcctcata  aggctttgc  tatttgttt  gaggaaaat  tctggagta  2160
acctttgtt  tctgaaact  ctttagcta  aagaaaatg  gtgttctag  ctttggaat  2220
gttcttaaa  tttcctgga  ataaaaata  tgattggca  ttcaaagac  ttctttagc  2280
aagacttca  tgtctagca  aaaccacaa  tgactagaa  agcaagtga  cttggtgat  2340
cacttgatt  tatacaatg  gtatttttt  tcttaaact  gaaataaat  tgttagaaa  2400
aatatagcca  2410



<210> 2925
<211> 259
<212> PRT
<213> Rattus norvegicus
<308> Q08755
<400> 2925

Met Pro Arg Leu His Asp His Val Trp Ser Tyr Pro Ser Ala Gly Ala 
  1               5                  10                  15
Ala Arg Pro Tyr Ser Leu Pro Arg Gly Met Ile Ala Ala Ala Leu Cys 
             20                  25                  30
Pro Gln Gly Pro Gly Ala Pro Glu Pro Glu Pro Ala Pro Arg Gly Gln 
         35                  40                  45
Arg Glu Gly Thr Ala Gly Phe Ser Ala Arg Pro Gly Ser Trp His His 
     50                  55                  60
Asp Leu Val Gln Arg Ser Leu Val Leu Phe Ser Phe Gly Val Val Leu 
 65                  70                  75                  80
Ala Leu Val Leu Asn Leu Leu Gln Ile Gln Arg Asn Val Thr Leu Phe 
                 85                  90                  95
Pro Asp Glu Val Ile Ala Thr Ile Phe Ser Ser Ala Trp Trp Val Pro 
             100                105                110
Pro Cys Cys Gly Thr Ala Ala Ala Val Val Gly Leu Leu Tyr Pro Cys 
         115                120                125
Ile Asp Ser His Leu Gly Glu Pro His Lys Phe Lys Arg Glu Trp Ala 
     130                135                140
Ser Val Met Arg Cys Ile Ala Val Phe Val Gly Ile Asn His Ala Ser 
 145                150                155                160
Ala Lys Leu Asp Phe Ala Asn Asn Val Gln Leu Ser Leu Thr Leu Ala 
                 165                170                175
Ala Leu Ser Leu Gly Leu Trp Trp Thr Phe Asp Arg Ser Arg Ser Gly 
             180                185                190
Leu Gly Leu Gly Ile Thr Ile Ala Phe Leu Ala Thr Leu Ile Thr Gln 
         195                200                205
Phe Leu Val Tyr Asn Gly Val Tyr Gln Tyr Thr Ser Pro Asp Phe Leu 
     210                215                220
Tyr Ile Arg Ser Trp Leu Pro Cys Ile Phe Phe Ser Gly Gly Val Thr 
 225                230                235                240
Val Gly Asn Ile Gly Arg Gln Leu Ala Met Gly Val Pro Glu Lys Pro 
                 245                250                255
His Ser Asp 
             260



<210> 2926
<211> 1469
<212> DNA
<213> Homo sapiens
<308> BC001880
<400> 2926

ccgcggccc  ccatataaa  ccgcgcgcc  gccaggcgc  gcggccgtc  cgggccgtg  60
ctcctcctt  cccccgccc  gcctccgtt  ggagagccg  cgggcgggc  cctctcggc  120
aggaagcgc  tcttggacg  gtgtgaccg  tgcccagat  gcacgacca  ttctggagc  180
gctcctgtg  gcacagcgc  aggcgccga  gccccccgc  agccagcgc  gcggggctg  240
cggccaagg  tggggagat  atcaacgtt  ccgtgtccg  gccctccct  ctggcggcc  300
acggtgccc  ggacgctga  cccgcgccc  ggggccgca  tgctgcgat  agcggcccc  360
agcccggca  cccctaccc  aacacctgg  atcatcgcc  gttgcagag  agcctcgtg  420
tcttctcgg  tggggtggt  ctagccctg  tgctcaacc  gctgcagat  cagaggaat  480
tcactctct  ccccgagga  gtgatcgcc  ccatctttt  ctccgcctg  tgggtccct  540
cctgctgcg  gacagcagc  gctgttgtt  gcctactgt  cccctgtat  gacagtcac  600
tcggagaac  ccacaaatt  aagagagaa  gggccagtg  catgcgctg  atagcagtt  660
ttgttggca  taaccacgc  agtgctaaa  tggattttg  caataatgt  cagctgtcc  720
tgactttag  agccctatc  ttgggcctt  ggtggacat  tgatcgttc  agaagtggc  780
ttgggctgg  gatcaccat  gcttttcta  ctacgctga  cacgcagtt  ctcgtgtat  840
atggtgtct  tcagtatac  tccccagat  tcctctata  tcgttcttg  ctcccttgt  900
tatttttct  aggaggcgt  acggtgggg  acataggac  acagttagc  atgggtgtt  960
ctgaaaagc  ccatagtga  tgagtcttc  aaaccaccg  ttctgagag  aaggaagat  1020
ttggaagaa  atctgactg  ggattatga  aaagattat  ttttttctt  agtaatcta  1080
ttagatcgg  ctgactgta  aaatgactc  tggaaaaaa  tcttcacct  gtctagaat  1140
gggaggtgg  gaatgatga  ttaccctga  gtcttccct  gactgcccg  actggcgcc  1200
gtctgtgcc  tggagcatt  tgcccaggc  acgtgggtt  aggcaggtg  cagcttccc  1260
agtattcga  ttcattcat  tgattaaaa  aagttgcca  atttcaaag  cttgaacta  1320
gactcaatt  ccaacccgc  gttttgtgt  agtgcccaa  ggaggtagg  tgatggtgc  1380
taacaaaca  gaagtatgg  gtaatagga  taatattta  ccaaaagat  tttaaaaat  1440
gggctgtgt  taaaaaaaa  aaaaaaaaa  1469



<210> 2927
<211> 277
<212> PRT
<213> Homo sapiens
<308> O15503
<400> 2927

Met Pro Arg Leu His Asp His Phe Trp Ser Cys Ser Cys Ala His Ser 
  1               5                  10                  15
Ala Arg Arg Arg Gly Pro Pro Arg Ala Ser Thr Ala Gly Leu Pro Pro 
             20                  25                  30
Lys Val Gly Glu Met Ile Asn Val Ser Val Ser Gly Pro Ser Leu Leu 
         35                  40                  45
Ala Ala His Gly Ala Pro Asp Ala Asp Pro Ala Pro Arg Gly Arg Ser 
     50                  55                  60
Ala Ala Met Ser Gly Pro Glu Pro Gly Ser Pro Tyr Pro Asn Thr Trp 
 65                  70                  75                  80
His His Arg Leu Leu Gln Arg Ser Leu Val Leu Phe Ser Val Gly Val 
                 85                  90                  95
Val Leu Ala Leu Val Leu Asn Leu Leu Gln Ile Gln Arg Asn Val Thr 
             100                105                110
Leu Phe Pro Glu Glu Val Ile Ala Thr Ile Phe Ser Ser Ala Trp Trp 
         115                120                125
Val Pro Pro Cys Cys Gly Thr Ala Ala Ala Val Val Gly Leu Leu Tyr 
     130                135                140
Pro Cys Ile Asp Ser His Leu Gly Glu Pro His Lys Phe Lys Arg Glu 
 145                150                155                160
Trp Ala Ser Val Met Arg Cys Ile Ala Val Phe Val Gly Ile Asn His 
                 165                170                175
Ala Ser Ala Lys Leu Asp Phe Ala Asn Asn Val Gln Leu Ser Leu Thr 
             180                185                190
Leu Ala Ala Leu Ser Leu Gly Leu Trp Trp Thr Phe Asp Arg Ser Arg 
         195                200                205
Ser Gly Leu Gly Leu Gly Ile Thr Ile Ala Phe Leu Ala Thr Leu Ile 
     210                215                220
Thr Gln Phe Leu Val Tyr Asn Gly Val Tyr Gln Tyr Thr Ser Pro Asp 
 225                230                235                240
Phe Leu Tyr Ile Arg Ser Trp Leu Pro Cys Ile Phe Phe Ser Gly Gly 
                 245                250                255
Val Thr Val Gly Asn Ile Gly Arg Gln Leu Ala Met Gly Val Pro Glu 
             260                265                270
Lys Pro His Ser Asp 
         275



<210> 2928
<211> 1356
<212> DNA
<213> Rattus norvegicus
<308> L14462
<400> 2928

cccggagct  tcgatcggg  acaaagcgc  gccgcccgc  ccccccgag  cgcccgagc  60
ggggccagc  ccccgcgac  gacatgatg  ttccgcaaa  ccggcactc  ggctcctcc  120
acctccccc  gcagctcaa  ttcaccacc  ccgactcct  cgaccgcat  aaggatgag  180
tccagctgc  acaagcgca  taccacagc  tgaagctgg  gtgtgacaa  ctggccagc  240
agaagtcag  gatgcaaag  cattacgtc  tgtactatg  gatgtctta  ggattgaac  300
tcgagatgc  caaacaggc  gaaattgtg  agaggctga  tgggatttg  gcccaggtt  360
taccctatt  gtcccagga  catcagcag  aggtcctgg  agctatcga  agagccaag  420
aggtcacgg  tcccgagct  aactccatc  tccgacagc  gctccaggc  caccagctg  480
cccagctcc  ggcgctggc  ctgcccctg  caccgctgc  tgtcgggct  cagccgcca  540
ccctccctg  ggtcagcgc  ggcacaggc  tgctgtcac  ctctgctct  ggctctcag  600
cccacctct  caaggagga  aagaacgga  acgatgggg  cacccacca  gaggatgat  660
gagagaagt  cgattagct  ctggggaga  ggaggggga  gggggatac  aggggagac  720
ggcacagag  gcacagtgt  ctgagggcc  cactgcaca  agctcggtc  ctacccaag  780
ttccacctc  agtcctggt  ccagctgtg  accctgggc  taggagacg  cagagggac  840
gcccaggct  cagggaaaa  tccccacct  caacatttc  ccgggctac  gccaccaat  900
tcggcccag  atgtacaca  cgctagccg  ccctttcca  cctgtgcac  ccgaatttg  960
cccctttcc  cttctctgc  tcctgcact  cacacctgc  aggcccaga  ccctccccc  1020
agctcaccc  gctctggtt  cctcaaccg  ggaaagaaa  cattggctc  ggactgcag  1080
gggggtggg  accccacaa  cttccctct  cccttcccc  aataaacgt  agggttaaa  1140
gtcggtttg  ttattattt  tttttcgtc  cagtactct  tagctacca  ctaagagag  1200
aaaagaagg  agccctgga  cgagcgagg  tctgtctgt  catatagtt  gatttttct  1260
gtcgcctcg  tttgcaccg  gaggtggag  gccgctgta  tgagggtgg  gtctagctg  1320
gccttcaaa  taaaaacat  aaaaggtca  aaaaaa  1356



<210> 2929
<211> 197
<212> PRT
<213> Rattus norvegicus
<308> Q06195
<400> 2929

Met Met Phe Pro Gln Ser Arg His Ser Gly Ser Ser His Leu Pro Gln 
  1               5                  10                  15
Gln Leu Lys Phe Thr Thr Ser Asp Ser Cys Asp Arg Ile Lys Asp Glu 
             20                  25                  30
Phe Gln Leu Leu Gln Ala Gln Tyr His Ser Leu Lys Leu Glu Cys Asp 
         35                  40                  45
Lys Leu Ala Ser Glu Lys Ser Glu Met Gln Arg His Tyr Val Met Tyr 
     50                  55                  60
Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Ala Glu 
 65                  70                  75                  80
Ile Val Lys Arg Leu Asn Gly Ile Cys Ala Gln Val Leu Pro Tyr Leu 
                 85                  90                  95
Ser Gln Glu His Gln Gln Gln Val Leu Gly Ala Ile Glu Arg Ala Lys 
             100                105                110
Gln Val Thr Ala Pro Glu Leu Asn Ser Ile Ile Arg Gln Gln Leu Gln 
         115                120                125
Ala His Gln Leu Ser Gln Leu Gln Ala Leu Ala Leu Pro Leu Thr Pro 
     130                135                140
Leu Pro Val Gly Leu Gln Pro Pro Ser Leu Pro Ala Val Ser Ala Gly 
 145                150                155                160
Thr Gly Leu Leu Ser Leu Ser Ala Leu Gly Ser Gln Thr His Leu Ser 
                 165                170                175
Lys Glu Asp Lys Asn Gly His Asp Gly Asp Thr His Gln Glu Asp Asp 
             180                185                190
Gly Glu Lys Ser Asp 
         195



<210> 2930
<211> 31737
<212> DNA
<213> Homo sapiens
<308> AC005944
<400> 2930

gatccgtcc  cctcagcct  ccaaaatgc  aggattaca  gcttgaacc  ccgcgcccg  60
cctgctttt  ttttttaat  aagacagtg  ctcgttctg  agccaggct  gagttcagt  120
gcgcgatca  ggctccttg  agcctcaaa  tccggggct  aagcaatcc  cccgcctca  180
cctccagag  agctgggac  acaggcaca  aacaccacg  ctgactatt  tttggattt  240
tagtagaga  agggttgtg  catctcagc  aggctggtc  tgaactcct  gcctcaagt  300
atcctccca  cttggcctc  caaagtgct  ggattacag  catgagcca  tgcactccg  360
cttattttt  ttttttgta  agatgatgt  ttcctatgt  gcccaggct  gtcttgaac  420
cctgggttc  agtgattct  caatctcag  ctcccaaag  gctggggtt  caggtgtgt  480
ccagcgtgt  tggctggac  cagggtctt  gtgtgggaa  tggggtagg  atgttgcga  540
acccaccct  cttttggtg  gtgagagtc  gaggaggcc  tcagaaaag  gacttctag  600
gagtctcag  gaattagaa  gcctgggag  ggaaataaa  agaaccctg  tccaggcag  660
gggaacagc  tgtgaaaag  cctcaaggc  agggacagc  agatgtttc  ccttggctg  720
agcctgttg  gtaggagtg  aaggaggga  gggtagggt  tcctgggcc  aggtgaaga  780
tttcgaatt  attccaagg  cagtgagag  caaagataa  ctttttttt  ttttttttt  840
ttttgagac  gaatctcac  ctgtcagcc  cgctggagt  cagtggcat  atcatagtt  900
actacagcc  tgacctcta  ggctccagc  atcctcctc  ctcagcctc  caagtagct  960
ggaccacag  tgcacaaca  tatgcccgg  tgattcttt  ttttttttt  tgagacgga  1020
tcttgctct  ttgcccagg  tggagtgca  tggtgcgat  tcagctcac  gcaagctcc  1080
cctcccggg  tcacgccat  ctcctgcct  agcctcccg  gtagctggg  ccacaggcg  1140
ctgccacca  gcccggcta  ttttttgta  ttttagtag  gacggggtt  caccgtgtt  1200
gccaggatg  tctcgatct  ctgaccttg  gatccaccc  ccttggcct  ccaaagtgc  1260
gggattaca  gcataagcc  ccgcgcctg  ccataattc  tatattttt  tagagatag  1320
gtctcacta  gttgcttag  ctggtcttg  actcccagc  tcaagcgat  ctctcacct  1380
ggcttccca  agtgctgag  ttacaggtg  gagccacca  gagcagcct  tcttttttc  1440
tgactgtgt  gtattctgc  gtgtgacca  gtcacaatc  atctatttg  ttgggggca  1500
ttatgacaa  ttacagcag  tctaaacac  cttgttcag  tctgttttt  tgttttgtt  1560
tgttttgtt  tgtttgaga  ggagtttca  tctgtcacc  aggctggaa  gcagtggcg  1620
aatctcagc  cactgcaac  tccgcctcc  gggttcaag  gattctcct  cctcagcct  1680
ctgagtagc  gggactgca  ggctgccac  acacccgac  aatttttgt  tttttagta  1740
agatggggt  tcactatgt  ggccaggct  gtcttgaac  cctgacctg  ggtgatcca  1800
tcacctcgg  ctcccaaag  gctgggatt  caggcgtga  ccaccgcgc  tggccaatt  1860
ttcgggtct  tttgatgga  tcatatgac  tttccgttg  gagatggat  caagagggg  1920
attgctgga  tatgtggtg  caagtggcc  tctgaagta  aggtaagag  ttacccttg  1980
tggccgggc  cggtggctc  cgcctgtaa  cccagcact  tgggaggcc  aggcgggtg  2040
atcacgacg  caggagatc  agaccatcc  ggctaacat  gtgaaaccc  gtctctact  2100
aaaatacaa  aaaaaatta  ctgggcgtg  tggcgggcg  ctgtaatcc  agctacttg  2160
gaggctgag  caggagaat  gcgtgaacc  gggaggcag  gcttgcagt  agccgagcc  2220
agattgtgc  actgcactc  agcctgggc  acagagcaa  actccatct  aaaaaagaa  2280
aggaaataa  aagaattta  ccttgccaa  gggtgtgcc  aggcgtgtt  aggtttcaa  2340
aagggtaaa  gtcagcagg  gatgatccc  tgcaactgg  atttttaga  gcactttgg  2400
tgcagtgga  atggggtgg  acctgccag  aggctggtg  gatcagcca  ccctgtccc  2460
tccactccc  gccctctcc  cagggacat  agacatttt  cccaatgtc  gctgtccat  2520
tccaccctt  tcagctccc  tcagctcgg  cttcctcct  ccgtgaagt  cctccagag  2580
agaaatggc  atctcccat  tgctgggtg  gcagcaaca  gttcccttg  cccaagtcc  2640
agaggagcc  ggggctgag  ccaagatgg  aaaactggg  gcaatcccc  ttccttctg  2700
cttccccac  gctggtgca  cttgggtga  gcggtgggg  ttggggggc  tctggctgt  2760
ccttagagg  tggaggctc  gctggggcg  gtcagtgtt  tctctgagt  tactggcca  2820
gcacggggg  tcacgcctg  aatcccagc  ctttgggag  ctgaggcgg  aggactgct  2880
gagcccagg  gtttgagac  tgggtaaca  ggtgaaacc  catttctac  aaaaaaaaa  2940
aaaaaaaaa  tatatatat  tatatatat  tatatatat  tatatatat  tatatatat  3000
tatatatat  caaaagatt  ggcgagtat  gtggtgcat  cccactgtc  cagctcagg  3060
ggctgaggc  gaggtggga  gatcacttt  gctcaggga  gttgaggct  cagtgagct  3120
tgatcacac  actgcactc  agcctgggc  acagagtga  accctgtct  aaaaaaaca  3180
acaaacaaa  aaaaaaaac  cacccagaa  cgaaaagaa  tgtacctgt  tgggcactg  3240
ggcctcctc  ttctctaag  gaagagaat  tcctttagg  cttcagatc  cgggtgcag  3300
aatcagctc  gccactgac  cacttattt  attattaaa  aaaaatttt  ttttaggag  3360
tggggtctt  ctatgttgc  caggttgtc  ttgcactcc  ggcctcagg  aatcctccc  3420
cctcagcct  cccacttac  agcttaggg  tcccttcgc  tttttaagc  cccttaact  3480
cctgtctaa  catcaacca  ctgggccat  ctgtgtgac  tgaagtctt  agctcaccc  3540
ctctgggct  ggcatcaga  cagtgtagg  caaatgcag  agcgtgacc  accaactct  3600
tttttttga  acagcgtct  gttctgtcg  ccaggctga  gtgcagagg  atcatctca  3660
ctcactgca  cctctgcct  ccgggttca  gcaattctt  tgtcccagc  tcctaagca  3720
ctggaatta  aggtgcacg  caccatgcc  ggctacttt  tgtattttt  ttttttttg  3780
gatggagtt  tgctcttgt  gcccaggct  gagtgcagt  gtgcgatct  agctcaccg  3840
aacctcctt  aattcaagt  attcttctg  ctcagcctc  taagtagct  ggatcacag  3900
tgcccacca  cacgcccag  ttttttgta  ttttagtac  gacagggtt  caccatgtt  3960
gccaggctg  tctcgaact  ctggcctca  gtgatctgc  tgcctcagc  tcccaaagt  4020
ttgggatga  aggcgtgag  cacaccgca  cgggccaca  ctaggaact  ctgatgttc  4080
aggaggatg  ctcacattg  aaggaaccc  gtcctcccc  gggggcagc  acaacacag  4140
ggcagggac  cagcaccga  gcttctcac  tctttattg  aaaggcaca  ctaagccca  4200
ccttgatac  gcattttcc  cttctctct  tagagatca  acgattgaa  acgagataa  4260
ctgactata  acagacaca  gtgtgggtg  tgctttttt  taaaaacac  tttgtcttt  4320
ttttttttt  atatcccct  tcttaaaag  caagctagt  tactggaaa  agaaaaaaa  4380
aataataaa  taaaaacca  gacaacttt  gtaccctca  ctttatttg  gaaggggag  4440
gggaatcct  ggtcgccca  cctcaccct  ctcctccca  ctcagctaa  ctcgtccct  4500
gtgcccccc  ttttgtggg  gatgggaga  gaccaggtg  gcgtggagg  gtctggaac  4560
agcagaggt  gtgagtggg  caggtggag  tgggagcat  cctgggacc  ggggtcggg  4620
gagactcgg  gtgcccagg  cgggaaagg  gcagctagc  ttgcgtgca  gcagtacca  4680
ggtgagagg  ctgtggccc  ggcagactg  cggttacac  tgttcaaaa  gggggaagg  4740
ccggggctg  tgcgcttcg  gaggtcttg  tcccttggg  cctggtctc  catctgacc  4800
tccaggcct  agcttgcct  acatgtcag  gcaggtatc  acctaacca  gctgcaggg  4860
aggaggagg  aagccggga  tggggtagg  agaaagcta  aggtggcct  caagctggg  4920
tggggcccc  gccggcggc  accataaat  ctatgggag  ttagccaat  ccgagctcc  4980
ctgtgtctt  tgctaaaca  tcctttctc  ccgtgcctc  gtctcccct  tgtcccccc  5040
cccaacctc  ctgtcccgg  cccctgcta  tccgacttc  cgccatcat  ctcctggtg  5100
gtgtcacca  cgtgcccgt  cttgtcttc  ttggagagg  gggcctggg  acccagcgc  5160
gacagcgag  ggaggccgg  gcctgcgct  accgccggc  gcgaaggcg  ctgcagccc  5220
acgggtagt  gggtcaagg  cagggccag  gcctgcagc  gggacagct  gtgggcttg  5280
agctgctgc  gcagggcgg  ggaggggaa  attagctgc  tggggccca  ctgtccccc  5340
cccacccgc  caggtcccc  tacatactc  gatgataga  ttcagctcg  gagcggtga  5400
ctgcttggc  ctctcaatg  ctcccaaga  ctgctgctg  tgctggaag  gggtcgggg  5460
agaggagag  cagtgattc  tcctgatcc  gggagagga  agggggacg  ccctgaggc  5520
aggaggagc  ccactacca  gtgggccat  atgtctgct  ctcccagtg  ttttcaacc  5580
catcagaaa  caccctccc  ctctccaac  gcttccttt  accaagctc  tctcttcgt  5640
tggccaaca  agacaaatg  aaaagtgca  aaaacaatt  aaagggttt  gtgctaagt  5700
gttaggaaa  agcttttga  tgagcccgg  agaaaccct  gatcctgac  tatcctatg  5760
gcacagcca  ctgcaaaga  gtgaaacat  tgaatgttt  tgcagtaca  aacctgccc  5820
actgtacag  gacgtcctg  tcctaggag  tccaagact  tgccctgag  ctggccaaa  5880
tgagccctt  tcctaccat  gctggggag  gcccaatga  ttctggcag  gctggctgg  5940
gaatgggct  agattcagg  cagttcctc  ctgagctct  cccaaacac  tgactctgt  6000
gccagcaga  gctagaatc  accaatctc  ctttttgcc  tggctacca  gaagcctct  6060
ttctgaagg  ctccaagtg  ccttttctc  agggctttc  ttgggtcct  ctaagactt  6120
tccctgggc  aagcagggc  cccaaagga  cctgagata  ccacaggga  tgaagagga  6180
gttacaaac  tttgacagt  aacttggca  ggacaggag  tgggcctta  atggccctg  6240
ggaggggcg  cctcgcatc  tgagcctca  aacccaaga  aggagaaga  gagctgggc  6300
tcaggttca  ctgggtgtg  gtgtgcatg  ggtaatgtg  gctcaggat  acgtgtgcc  6360
acgtgtagc  gcacattcc  gcatgcgtg  ccctgtgct  tctgcacac  cgtgtatcc  6420
tgtctgcat  tgtgtatct  ccgtgtgtt  atgtgctcg  gcctatctg  gtggctgtg  6480
ccatgtgtg  ccaccctgt  ctacccctt  ccccacaat  ccctaacac  ctctagtcc  6540
tggtcctgt  cagcccgca  ggcctggag  aggatgtct  aagagggtg  aaggaggaa  6600
agagatgag  aaaaaacat  cctggtgca  tttaggccc  tctgacatt  ctacctatg  6660
catgactca  tccagctgg  aattccaga  cagggtgag  cccgccccc  acacgcctg  6720
acccctgga  tgtctctgg  ccggggatt  ttctgcaca  gccggctct  gtgttcaga  6780
ccagggagg  ccagagagg  gaggcgtgt  ccctggggc  cccagcaca  cacccaaga  6840
ggctgcagt  gacaggggc  gggcaagtg  ggggccccc  cacaacccc  ccccaaggc  6900
ctggctctt  cctcttggg  gaggtaggg  aggacctgg  cacaaatcc  gttcagcct  6960
ttgacgatc  cagcctgga  cacacagat  aagccggct  cagtcctgg  cgggtggca  7020
gtgcaggct  gccacagga  gcctgcgcg  ggcccggcc  agccctgcc  cttgcggct  7080
ctaagaggg  ctaggtctg  ccagggtgg  atgagcaaa  ccgtgttcg  gcccgaggg  7140
agccagtca  tggcaaagg  ggggctgga  accggctgt  gcctgcagc  tagagtgag  7200
taagtgcag  atgaggcca  actgcacat  cctcggggg  cggccactc  ggcccctgg  7260
aggtagtaa  cgcttgtgc  aatgtaggg  gggctgggg  ccgtaggct  tggggaagg  7320
ctctgcccc  ccccaccac  gggagaaac  ctcccaggg  ggcctgaaa  agaggcggg  7380
cggggggga  gagagcggg  gcttgggga  ggcttagga  gtaacagga  aaccgggct  7440
gcttggtgc  cagccgagg  ccggccgct  cctgcctgg  ggtgcccaa  gcggggctg  7500
aggtggggg  aggaggggg  aggaggagg  ggaggagga  gaggaggag  tgggcgtac  7560
tgtttgtgc  tctcgatgt  caagccgta  gacatctcg  agtactgta  gggggagag  7620
gagggggag  gggagatgg  ggtggggaa  gatgggggg  cacggagac  aagagatag  7680
ggagtggca  agacagaca  aggggggag  cagcaagag  cagctgagg  caggaaaga  7740
aggagaggc  ggtgggagg  aaagaggag  gagagacgc  cacacccag  atcccagcc  7800
gccctggag  ggggcaggg  gccgctggg  ctgcggatg  agactgggg  cactttagg  7860
ccctagccc  ggcctggct  ctcccccac  ccatgtgca  cgcgagaac  cgcattcca  7920
ggctcctaa  cttgtatct  tctatgtct  gtctgcggg  gggcccaga  gccagggaa  7980
tttgcctgc  taggtataa  cagtgaggg  taaacaaag  ctgctggct  tggggccag  8040
agctacccc  accccaagc  ccagatctc  ccctgcccc  cccctgctc  aaaccctcc  8100
atggctccc  gtcacccct  ggggaaaac  aagttcatt  ccaggcctt  acgtagttt  8160
tctgtctct  tctggtgaa  tcctactca  cctgcaaga  cccagctgt  tgccccatt  8220
ctccatata  tcttcctca  gcaggtcct  ggtccctct  tctgacccc  gccctattc  8280
tctggctgg  agggtcagg  tctggctct  cctccccca  agtctggga  atttgggta  8340
tgggctgag  ccccagcat  gctgctcga  ggccaggcc  agggtgggt  agggagggg  8400
tttttgatg  agaaatcgt  acctggcag  tacaaaacc  agcaagtgg  tctggcagc  8460
gcaatgcag  gtcacacat  agccccccg  aatgggtag  gctcagacc  cctcccaca  8520
gcttcttct  tgagctcgg  cccaaaggg  ttaagcgtg  ggacgctgg  accttggcg  8580
tggggaggg  ctcggctgc  cccccacgt  agttcctgg  tgttggctt  cacagccgg  8640
gagcctccc  ctcctccct  ctccgctgc  aaggacagc  gggggacct  gcagggccg  8700
tctgcaacc  ggcggtttg  cacctcggc  actgcctcg  ccatctgcc  ggctagcga  8760
gcaggctca  cccagcagg  gccggctga  tggagaaca  gccccgatc  tcgcgcttc  8820
caggggagg  ggccggggt  gagggagca  ctgcccgtg  tggagggga  gtggagggc  8880
ctgtcgccc  cccccaaca  tggacctgg  ggcggagtg  cgttaccat  acatagtga  8940
gctgcatct  tgacttctc  ctggccaac  tgtcacatt  gagcttgag  ctgaggagg  9000
acagggggg  gatggggtg  ttagtggcg  ctgggcggg  gccccccac  ctccgttat  9060
caggggagg  aactgaggc  ccaagtccc  tgtaagggc  agatcagcc  attctcaga  9120
ggtcaagca  taatttttt  tttaaattg  gacgggggt  tccctatgt  gcccaggct  9180
gtctcaaaa  ctcctgggc  caagcaatc  tccttcctc  gcctcccaa  gtgcttggg  9240
ttacagata  gagccaccc  ccgtgcctg  tcaatgaag  cgtaaactt  cataggggc  9300
gaggacatt  aattgaggg  cagggaagt  ggtaagagt  gagctctct  tgatgctgc  9360
gggagggga  agcatcagg  cccctgact  taagaaggg  gtgatgaaa  cacccttgc  9420
gatctggtt  gggggaaat  agcaacatt  tagtaacat  ataggaaca  cagaagtta  9480
agggggcac  gtaacgcta  ctctgagag  ctcacgagc  ttcacctct  acggtcccg  9540
cgaggcccg  aacgtcatt  tcacgctcc  tttatagat  acacagtgg  cacccagag  9600
gggtgagga  ctggctcaa  gtcacacag  caagcagca  cccaagctc  caaccacag  9660
ggaaaattt  ccagaccca  atagaacgt  caaagaggc  gagagggtc  ggggctgca  9720
ggcggctcc  ggctggact  cccaagggg  ccctagctt  atggggggc  tggacttcc  9780
aggcagacc  ctcagctcc  tcttagtcc  tcctaacag  cttttttct  tagctggga  9840
aaaacacac  atttctccc  ctccacctg  ccagtccgg  tggctgaca  cagagcttc  9900
tacaggccc  cccgggaag  atgagctgt  gggcgtttc  caaagcccc  atgagggcg  9960
catggccgg  gggaagaga  caggcagga  ggcctccca  tccaggaaa  gaactggtg  10020
tggtggtgg  ggaggtgtc  tttaaccta  ttaaatcca  cccagcaca  gggccctgc  10080
gacctggct  tggcttacc  gcttctgcc  tccccaccc  ctctcggac  gggttcaaa  10140
ctcagccct  cgtcttccc  gctgtgtga  tctaggcaa  ctccactac  tctctgggc  10200
tcatttcct  ctctgtgag  taccactaa  aacctcgca  ggtggggtg  agaagagtc  10260
atgaattca  acaagaaaa  ttctagaac  gtacctggc  tacagtaag  atcccataa  10320
tgcacatgg  tcttaggat  ccccaggaa  ctggcattt  gctccaccg  agaagagtg  10380
gccgggtta  ggatgcttt  gccgccacc  atttttctc  agttttctt  taaaatgtg  10440
atttgttgc  accattaaa  acaaaaaca  aaacaaaaa  aaaccgggg  tgggtgcag  10500
ggctcacgc  tgtaatccc  gcattttgg  aggccaagg  gggtggatc  cttgaggtc  10560
ggagtttga  accagcctg  ccaacataa  gaaagcccg  ctctaccga  aatacaaaa  10620
ttagccggg  gtggtggtg  acgcctgta  tcccagcta  ttgggaggc  gaaacagaa  10680
aatcgcttg  atcccaaag  tggaggttg  agtgagccg  gatcgcgcc  ctgcactcc  10740
gcctggcga  agagcaaga  tccgtctca  aaaaataaa  taaaataaa  aagaagttt  10800
actccaaag  ctgcatttc  ggcctttct  gaaaaatag  atggtctgg  cacccaggg  10860
ctgttacgc  tcgaacatc  ggtgtgtgc  tctgatatg  tagggtccc  cgttggaca  10920
caggaagcc  aggcccagc  gatggagac  ccaaagctc  gagagggct  ccggcttag  10980
agaggtcac  cagcactgt  accgccatc  gatcccttc  ctgtggaat  aggtcagcc  11040
cggggctca  caggcggta  ccaaccctt  atatcgagg  acccgcaca  aagcttctg  11100
ggcctgcat  gaaagctga  tccagcacc  tcgactgtc  gtgtctcag  ttgcccagc  11160
tgagaatgg  tacgacagt  ggacgacag  aaggatgaa  cacgaggag  cacgaacgg  11220
cttgagcac  cagggagta  ccaaaaagg  gggatattt  cagcagcaa  aacaaaatc  11280
agattcccc  ttctacttg  aggaaatcc  ggatccttc  aggaacact  ctggggtgg  11340
cacgcttca  tttagagag  gccccaagg  caaacgggg  tttgagcat  gcctgactt  11400
ctccagatt  ccaggcccg  cgtgcccct  cagagcagg  caggcgaga  cctatatcc  11460
taaaccagg  gagagacct  gtgcaaacc  cagccttgc  acttcctca  tgctatgga  11520
acccccgag  aaataacat  ataacatct  tgggcttaa  tttcttttt  tctttcttt  11580
ttttttttt  ttttttttt  gagacagag  ctccctgtt  cccaggctg  agagcagtg  11640
ctccatctc  gctcactgc  acctccgcc  cacgggttc  agcaagttt  ctgcctcag  11700
cacccgagt  gctgggatt  caggcgccc  ccaccacac  cagctaact  tgtattttt  11760
gtagagacg  ggtttcacc  tgttggcca  gctggtctc  aactcctga  ctcaagtga  11820
ccaccttcc  cggcctccc  aagtgctgg  attacaggc  tgagccacc  cgcctggcc  11880
gggcttaag  ttctttaag  gtaagagga  taaatagtt  cttcccctt  gataccgca  11940
cgtggcaag  tcttcagaa  cgccagatt  ctgaaagaa  cagcacctt  gagaatctg  12000
cgggtgctg  gaacccttt  tccaaaact  ggcaaagag  gagatgacc  ggctgcaga  12060
tgtttctgt  ttgggggtt  agggatggc  agtccgtgc  gtaactcca  ttgttggaa  12120
gtcttttat  caatggggg  cttgggggt  ttggggagg  gggaggggc  ctgaagcca  12180
acagctgaa  ctttgggca  attatttaa  tatttttgt  cctcggttt  ctcctctac  12240
aaatggggc  gtttaaaat  aatgaattc  gtatttgtc  agtgattag  tcagagtct  12300
gcatatatt  ttttcccaa  ctccaggcc  cagccttgc  atctgcgca  aagaaatgg  12360
gggactcac  ttctcggga  gcagggacc  ccagtcccc  agctcacct  tggtactga  12420
cttgcagta  ctgaaattc  tctttgatg  ggtcgcagg  gtccgaggt  gtgaatttg  12480
gttgctggg  taggtgcga  gagccctgt  gggatgggg  ggcccgggt  aggcccagg  12540
gtgggctgg  cccccctca  gggccggct  ggagggagc  gccgcgcag  tgcggcgcc  12600
cccctcctg  cccacttcc  gggcccgtg  ttacggccc  tggcgcgac  ccacccgcg  12660
ttcctgccc  ccgcctctc  cgggggaag  cgagcgggt  ggtgcgccc  gagccgccc  12720
gtcccccgc  acccccagg  agtgggggt  cgttttaag  cccgcccta  atggggggc  12780
gggtgcgcc  tctaccgcc  tccaaagcg  cgggaggga  tgcacatcc  aggggggta  12840
aaacgcgcc  tagggagcc  cctccccaa  ttggggggc  gcgattcct  cctgcaaag  12900
cctcttggg  gaggggtct  tctctcggt  ctcgaaatc  tccgggggg  cccaacccc  12960
gattcccag  gcccttcct  ggggacacg  tcttccggg  ggggtgcgc  tcggatcac  13020
ccccccacc  caggccccc  aaggatccc  gggctagag  tgcctcgcg  ggcttccgg  13080
gcgccccag  cccgaggcc  aggccgtcc  aggccctga  tgtcccggc  ggttggggg  13140
ggggggcgc  aagccggga  ctgcggcgg  ggggctcgg  gcccggaag  tggggtgga  13200
cgggaactg  agggggggt  tccgggggc  ggcggcagg  ggggagggg  gtcgcgccg  13260
gctgggagc  ggagaggga  gacagggcc  gggagttgg  gggggcgcc  ggccggagg  13320
accgggcct  ggggttggg  ggcgcgggg  cgggagccg  gggtcgggg  cgtagggcc  13380
ggatccggg  tgggggcgc  ggccggacg  gccccgctt  ccgaatgcc  gctttgtgg  13440
aacatcatg  caatcgcgg  ggggggcgc  ggctgcgcc  cggctgtgc  ccccggctc  13500
ggctgctgg  ggcgccggg  ggccgcgcc  ttgtcccgg  gccgatcgg  agctcccgg  13560
gccgccgcc  cctcccgcg  ccggcctcg  ccgcttcct  cgccccctc  ccgcgcgcc  13620
ggccccggc  cgccccggg  cccgcttcc  gcgcgcccg  cgcccctcc  cgcccctcc  13680
cgccgcccg  ctccccgct  cccggcccc  ccgctattg  ctaatggcg  cgacgccgg  13740
agtggccgc  gctcggctg  tgcggaggc  tcggctcca  ctgccgccg  ccgtgcccc  13800
tgcgcgccg  cgagggggg  gacgcgcgc  cccggggag  cctgcggat  cccacgccg  13860
cccgcctcc  cgtggcccg  ccgccgcgg  gaccttggg  ccggcccgc  cccgccccg  13920
gcagcggcc  ccgccaccc  ctcctaccc  gcagccggc  gggcctcgg  ttccccatc  13980
gtcaaagaa  agggacccg  ctgcccgcg  cgaagccgc  ggccctgct  tggcacgac  14040
tggacgcgt  ccacggacg  gctctgtga  cttggctct  gctgggcgg  ggttcttgc  14100
gagccttag  ttccttttc  gcagaaagg  agcggtaat  ccgccttcc  gagggaagc  14160
attcttgtg  cacatttat  gaacgccta  tgtgtgcca  gccccgctg  tccagggcc  14220
tggggtggg  cggggcggg  gtgggtccc  gccctggtg  tggtgcctg  agacagaca  14280
agacaaatt  acaagctga  ttcctggca  gtcagatgg  ggggacagt  ctgcagaaa  14340
accagccgg  agaatggca  ggtaggaag  tgcaaagtt  aagaggtgg  agggaggat  14400
agagacggc  tcctccacc  ctaaagcga  ctgaagaag  agggagaac  gggggatgg  14460
gtacagagg  agtcagagg  aggaccaac  ggtgcaaag  ccctggggc  ggactgtgc  14520
tggcagcag  gtgcccggg  ggaggtcag  aaggccgga  ggaggcagg  ccgggggct  14580
cgtgctttt  tccagggcc  ccccacccc  cagcagggc  tgtgcttgg  ttaatattt  14640
ctgctgcat  ttgagattt  taatcattt  tgaacaagg  gcctttgag  tttcttttg  14700
actgggccc  gctaactct  tagctggtg  agcaggcca  tccagcaag  acttgtggg  14760
cttggggag  acttgggat  ttgctctga  tgaggtagg  gccctggaa  gctgtggga  14820
gaggaggga  gggacctgg  ggttggttg  tttgttttt  gagatggag  ttcgctctt  14880
ttgcccagg  tggagtaca  tggcacaat  tcagctcac  gcatcctgg  ttcaagtga  14940
tcctgcctc  gcctcccga  tagctggat  acaggcacg  gccaccacg  cccgctaat  15000
ttggagttt  agtagagac  gggtttctc  atgttggtc  ggctggtct  gaactcccg  15060
cctcagatg  tctgcccgc  tcggcctcc  aaagtgctg  gattacagg  gtgagccac  15120
gtgatcagc  gtttgtttg  ttttgagat  gagtctcac  ctgttgccc  ggctggagt  15180
cagtgatgt  atgttggct  actgcagcc  ctgccaccc  gattcaagt  attctcctg  15240
ctctgcctc  tgagtagct  ggattacag  tgcgcatca  cacgcctgg  taatttttg  15300
atatttagt  gagacaggt  tcaccatat  ggccagact  gtcttgaaa  cctgacatc  15360
ggtgatcct  ccgcctcca  ctcccagag  gcagggatt  caggtgtga  ccactgcgc  15420
tggccctgg  cttgggctt  tgctctgag  gaggtggga  tcctggaga  ccgtgggaa  15480
aggagggat  ggacctggt  gcggttatt  aaggatccc  ctctctgcc  cgcagagaa  15540
aggtcccaa  gaggctact  aaataaggc  atgacatta  ggtccccct  tggcaggtg  15600
gaaacacag  ctcttcatc  tcgtcatcc  ctaggcagc  tgctccctt  aatgaatgc  15660
attgatttg  gccttgggt  ttcccatct  taaaataga  ttggaaccc  aggctcctt  15720
ccttggcag  taagggtga  agccttcag  gatcaagat  aataatctt  aaagcagtg  15780
tttaatatt  ttattaaaa  aaaattttt  ttttgaggt  gagtctcac  gtgtggccc  15840
ggctggagt  cagtggtgc  atctcggct  actgcaagc  ccacctccc  ggtttatgc  15900
attctcctg  ctcagcctc  cgagtagct  gggctacag  cgcccacca  cacgcccgg  15960
taatttttt  tatttttag  agagacgga  tttcactgt  ttagccagg  tggtctcga  16020
ctcctgacc  cgtgatctg  ctgcctcgg  ctcccaaag  cctgggatt  caggcgcga  16080
ccaccacac  cggcctaaa  aaatttttt  agacacagt  ctctgttgc  taggctaga  16140
tgcagtggt  caatcatag  tcactgcag  ctcccactc  tgggctcaa  tgatcctcc  16200
acctcagca  cctgagtag  tgggactac  ggagtgcac  accatgccc  gctaatttt  16260
acatttttt  taagccggg  gcagtggct  atgcctgta  tcccagcac  ttgggaagc  16320
gaggccagt  gatcacaag  tcaggagtt  gagaccagc  tggccaaca  ggtgaaacc  16380
cgtcactac  acaaataca  aaattaccg  ggtgttttg  cgggcgcct  taattccag  16440
tacttggag  ctgaggcag  agaatcgct  gaagctggg  ggtggtggt  gcagtgagc  16500
aagatcgcg  cactgtact  cagcctggg  gacagagtg  gactctgtc  caaaaaaaa  16560
aaaaaaaaa  agatgaggc  agaaaggat  aggattttg  atttttaag  ttactacta  16620
ttggtggcc  ggtgtggtg  ctcacacct  taatctcag  gctttggga  gccgaggca  16680
gcggatcac  tgaggtgag  agcttgaga  cagcctgac  aacatggag  aactccgtc  16740
ctactaaaa  tacaaaatt  gcctggcat  gtggctcac  cctgtaatc  tagccactt  16800
ggaggctga  gcaggagaa  tgcttgaac  tgggaggtg  aggttgcgg  gagccaaga  16860
tgtgccact  cactccagc  tgggcgaca  gagcgaaac  ctgtctcaa  aaaaaaaga  16920
acaaagaaa  agagattaa  actacttag  aacagccaa  ccttcaacc  accgcaaca  16980
ccttgtttt  cctgcaggg  cctgagaga  tgcgttcct  gactgcccc  gaagccagt  17040
ctgccgcta  cacccctgc  accccaccc  cactgccgt  gggaccaga  accccctct  17100
ctgggaggc  acctgccag  gtttattta  gcaggcgcc  tccggtatc  gtgtgcccg  17160
ccagtgacc  aacagcccc  ttttcgaag  ccccacact  tcaggggaa  cagaactgg  17220
cacagatac  ttgagcacg  tgaggtgag  gctgggcca  ccacaggga  ctaggcctg  17280
gaaggagag  gtcattgtg  aatcatcgt  tttagaaaa  aggtttttt  tctgcatag  17340
aggcagccc  gaatggtgg  ccacactat  aataatcaa  caagccaca  aggtctgta  17400
gtttttgct  cgcaccagg  gctgcctta  gcactttaa  ctttaggta  agttgtcac  17460
cccatttta  agatggggg  aaaacaggc  ggcagggtg  ctcaggcct  tcatcccag  17520
actttagga  gccgaggca  gcagatcac  tgaggatca  gagtttgat  ctagcctgg  17580
caacatggc  aaaccccgt  tctactaaa  atacaaaaa  taaggcgtg  tggtgggcg  17640
ctgtaatcc  agctactct  gaggctgag  caggagaag  gcttgaacc  ggaaggcgg  17700
ggtttcagt  agccgagat  gtgccactg  actccagcc  gggcgacag  atgagactc  17760
gtctccaaa  ataaaaaat  aaaaaaaag  aaacgaaaa  aaatgggga  agtgagtca  17820
agagaagtg  agtgacttg  ccaagtggg  agggggcag  accacgatg  tatcccagg  17880
ctttgatct  gaccttggg  ctttgagca  tctgcagtg  ggcttctgg  cgggacacg  17940
tggcagcac  tgctgctgg  ctgaggagc  gggatttta  ctggagggc  ctagggagc  18000
acaggaggt  ttagagcaa  attcttcag  tagcgccat  gcattccac  ctgggcgac  18060
gagggagac  ccatctcaa  aaataaaag  agattgcat  aaaatagtg  ttatcctga  18120
gacttaggt  tttggcatc  ccttagctt  tttattttt  tttgagaca  ggttcttac  18180
ctgtcaccc  cgctggagc  cagtggtgt  acttcggct  actgaagcc  cgacctccc  18240
ggctcaagc  atctgccca  ctcagcttc  cgagtatcc  ggatgaaaa  cgtgtgcca  18300
cacgcccgg  taatttttg  ttttcatag  gatggggtt  caccatgtt  cccagactg  18360
tcttgaact  ctgggctcc  gcagtctgc  ctcctgggc  tcccaaagt  ctgggatta  18420
aggtgtgag  caccacgcc  ggcccctct  aagtttgac  cctgaaaaa  ggacctcac  18480
ctcggccgg  cgggctcac  cctgtaatc  cagcacttt  ggaggccga  gcgggcaga  18540
catctgagg  cgggagttc  cgaccagcc  gaccaacat  gataaaccc  gtctctact  18600
aaactacaa  attagccgg  cgtggtggt  ggtgcctgt  ataccagct  ctcaggagg  18660
tgaggcagg  gaatcgctt  aacccagga  gcagaggtt  cggtgagcc  agatcacac  18720
attgcactc  agcctgggc  acaagaatg  aactccatc  caaaaaaag  agaaaaaaa  18780
aaaggacct  actctcaag  acactcatc  tggtcctag  cctgcctca  tcaaatagc  18840
aagtctgct  tttggacat  ctggcccag  tcattcatt  tcttggggg  caaggggcg  18900
cctgggcac  gcagggtgc  gagcggtgt  cctggcctc  actcactcc  tgccagggg  18960
acccccgag  tgttccgcc  acaggtgtc  ccagacatc  cccagtgtc  cgtgggggg  19020
acaatgaca  gagaatgag  acccctggc  tagagcatg  aagaaacag  gcagctggt  19080
gtagaagat  ctccccggt  gtgtgatgg  aggattagg  gagagatgg  cagcctggg  19140
tgggcccat  gcaaagagc  tttttgggg  gcataacaa  aacagaatg  agatggcgg  19200
agggtgagg  agggcagac  gcttgccgc  ggagggaat  tgtaattaa  tggcgagaa  19260
tggggttta  gcacatcac  gtgtctggg  ggctgccac  gagcccccc  accccacac  19320
cataacccc  cacccccgt  cctgacccc  cgtgtccgg  tcacggtcc  tcctctccc  19380
gggattctc  gggccacat  tggggccaa  gcggggcgg  gatctgtct  atggatcca  19440
tcgtctgag  ccaggctca  ggcctggtt  caaatgagc  ctgggcccc  cggcctcca  19500
ggcagagcc  ggcgctggc  cgtgatgga  ggggccgca  ggccattaa  cacaggccg  19560
ggaggaaac  ggtggccgc  gtgcagaag  agggacctc  ctctgctgg  cccgggtgg  19620
ggtaggact  agctgtcca  ccctggggt  gagctcccg  actgctgct  cctggccgg  19680
tgacgtggg  ccatgagag  tcactgctc  agaccttag  gtcacccca  tgctactcc  19740
aaatgcagc  tcagatact  agagagcag  tactgtgtg  caggcatgc  tgtaagtgg  19800
ggttctgag  agtgaccaa  gagagaaat  cccccactc  accttttgg  gctgataag  19860
ttaaaactt  tatttattt  tatttttgg  gacggagtt  agctcttgt  gcccaggct  19920
cagtgcagt  gcacgatct  ggctcactg  aacctctgc  tcccaggtt  aagcgattc  19980
cctgcctca  cctcccgaa  agctgggat  acaggcgtg  gccaccacg  ctggctaat  20040
gtttgtatt  ttagtagag  tggtgtttc  ccatgttgg  caggctggt  ttgaactcc  20100
gacctcagg  gatccaccc  cctcggccc  ccaaagtgc  gggattaca  gcgtgagcc  20160
ctgcacctg  ccccattct  gattgaagt  tcactctct  aatgaagct  ccttcagct  20220
ccctatttg  ctgaggcag  gctaggacc  gggtgaatg  acctgggag  gaggtcctt  20280
cttaaggca  aaaacttaa  agaggcagg  tgaggtggc  cacgcctgt  atctcagca  20340
tttgggagg  caaggaggg  agattgctt  atcccagaa  ttcaagacc  gcctgggta  20400
catggtgaa  ccccaactc  acaaaaaac  aacaaacaa  aattagcca  gtgtggtgg  20460
gtgtgcctg  tgtcccagc  actcaggag  ctgaggtgg  aggattgct  tagcccggg  20520
ggctgaggc  gcagtgagc  aaaatcaca  cattgcact  cagcgtggg  gacagagtg  20580
gaccctgtc  caaaaaaaa  aaagaaggc  gggcgcggt  gctcacgcc  gtaatccca  20640
cactttggg  ggccgagac  ggcggatca  aaggctagg  gatggagac  atcctggcg  20700
gcgcgcaca  acacacaca  acacacaca  acacgccgg  cgtggtggc  ggtgcctgt  20760
gtcccagct  ctcgggagg  tgaggcagg  gaatggcgt  accccggga  gtggagctt  20820
cagtgagcc  agatcgcac  actgcactc  agcctgggc  acagagtga  actccgtct  20880
aaaagaaaa  aaaaaaaga  agaaaaaaa  agttaaggg  atgccaaat  cctaagtca  20940
caggataaa  actgttttg  tgcaatcta  gtgtttttt  gtttgtttg  tttgttttt  21000
gagacagag  ctcgctctg  cgcccaggc  ggagtgcag  ggcatgatc  cggctcact  21060
caagctccg  ctcccgggt  cacgccact  tgctgcctc  gcctcccga  tagctggga  21120
tacaggcgc  cgccgccac  cctggctaa  tttgtttgc  tttttagta  agacggggt  21180
tcaccgtgt  agccaggat  ctctcaatc  cctgacctc  tgatccacc  ccctcggcc  21240
cccaaagtg  agggattac  ggcgtgagc  accacgacc  gcccacttt  ttttttttt  21300
ttttttttt  acggagtct  gctctgtcg  ccaggctgg  gtgcaatgg  gcaatctcg  21360
ctcactgca  cctctgtga  ccactcacc  ccccttccc  agtgctggg  ttaccggca  21420
gaaccaccg  gcccagcca  caatatttt  acaaatcaa  attaatgaa  aaaaatcca  21480
aatgaacaa  atatcaaaa  gttaaataa  aatcttgca  aactcactc  gactgcctc  21540
taggcccag  tcatagagg  ctcaaccca  attccgcgt  caggtcatg  ggtcagcgt  21600
ttccctgct  catgggaca  agcactgtc  gacgtgtaa  gcggtttgt  tgtttactt  21660
cttgaatgt  ggccccggg  ggcaggggg  ttggtgagt  ctggtcact  ttgtatcct  21720
aatacctag  acagggcct  gctcagtat  aatgcccaa  agttactga  tgagtgaat  21780
aataaatga  tgggttaag  tgacacacc  ggttgttgc  gaattaaat  agataagac  21840
ctggaagta  ttagcacac  gcacccagt  ggctcctga  atccttaat  tacacctta  21900
ggcctgagt  caatgttct  attggccag  cctgggtca  atgacatcc  tgagacaaa  21960
tttatggct  gagtagaat  ctctgattg  ccagccttg  gtcacatga  ttttctttt  22020
tctttttct  ttttttttt  tttttttga  acagagtct  gctctctcg  ccaggcagg  22080
gtgcagtgg  cggatctct  ctcactgca  actccgctt  ccggtttca  gccgttctc  22140
tgcctcagc  tcctgagta  ctgggacta  aggcgcccg  caccacgcc  ggctaattt  22200
ttgtatttt  agtagggac  gggtttcac  gtgttagcc  ggatggtct  gatctcctg  22260
cctcgtgat  cacccgcct  agcctccca  agtgctggg  ttacaggtg  gggccagca  22320
gcctggcct  gacaattac  tcctctgag  ggccttctc  aaccagtca  atggaaaaa  22380
caaaaaata  tgttattat  tcactctat  ttattgtta  ctattttta  ttatttatg  22440
ttatttaac  ttttgatat  tatttattt  tgagacgga  tctcgctct  tcacccagg  22500
tggagtgca  tggcatgat  tcggctcac  gcaacctcc  actcccggg  tcaagtgat  22560
ctcctgcct  agcctcctt  gtagctgag  ttacaggca  gtgccacca  gcccggcta  22620
ttttgtagt  ttagtagag  cggggtttc  ccatgttag  caggctggt  tcgaactcc  22680
gacctcagg  gatcccccc  gcctcagcc  cccaaagtg  tgggattac  ggcatgaga  22740
accgcgcct  gcccaattt  tgtattttt  gtagagatg  gatttcacc  tgttggcca  22800
gctggtctc  aactcctga  ctcaggtga  ctgcctgcc  cagcttccc  aagtgctgg  22860
attacaggt  tgagccact  caccctggc  gggctgatt  ttttttttt  ccaagagtc  22920
gggtctcac  atgttgccc  ggcttgtct  gaactcttg  ggtcaagca  tcctcccac  22980
ttggccttc  agagtgctg  gattacagg  atgaaccat  gtgcctggc  taattttat  23040
ttatttttt  agtcagtgt  ttgggctgt  atgcaggct  gagaacagt  gtgccatca  23100
agctgattg  agcctcgaa  tcctggcct  aagtgaccc  cccacctca  cccctcaaa  23160
tgctgggac  agatgcgtg  gccaccagg  aggccagct  tcatcttta  tatctgtca  23220
cctgaaaga  ccatgagag  aaggagcgg  ctgccttct  cactgctgt  tcccagggc  23280
cagcttggg  tctggcaaa  aatttctac  cagtgcaaa  atcaggtct  agtgaaatg  23340
aagaatgag  tagtattta  ttatctgga  atggagtct  gctctgtcc  ccaggctgg  23400
gtgcagtgg  atgatctgg  tctcggctc  ctgcaacct  tgcctctcc  cccgagttc  23460
agcaattct  ctgcctcag  ctcccaaat  gctgggatt  aagatgtgt  ccaccatgc  23520
tggctaatt  ttgtgtttt  ttgtttgtt  gtttttgga  acggagtct  gctctgttg  23580
cagactgga  tgcagtggc  cgatcttgg  tcactgcaa  ctccacctt  tgggttcaa  23640
tgattcccc  gcctcagcc  ccccagcag  tgggattac  ggagtgtgc  gccatgcct  23700
gctaatttt  tgtatgtta  tagatatgg  gtttcacca  gttggccag  agggtctcg  23760
tttcctgac  ttgtgatcc  cccgcctca  cctcccaaa  tgctgggat  acaggcgtg  23820
gccaccgtg  cctgcctta  ttttttatt  ttagtagag  cagggtttt  ccatgttga  23880
caggctgct  tcaaactct  gacctcagg  gatccacct  ccttggcct  ccaaagtac  23940
gggattaca  gcgtgagcc  ctgtgcctg  ctgacagta  ttatttatt  tccccatat  24000
ccagatgag  aaactgtgg  tcacaaagg  gcgatcatg  attttgtct  ccttcctct  24060
cacccccag  gctctgtca  acaacatgg  tttattgaa  acttgcacg  ctggtcttc  24120
tctagatat  agggataca  tgacccaca  agctccaac  ttacagcct  gcaggggag  24180
cagacatta  taaaatcac  atacaaaca  atgtggtta  aatccctca  caatcccat  24240
ggctccagc  ttaccaata  acccagaat  caatcaatt  ccactaact  tagggttac  24300
atcctggct  atatcccca  caacttgtt  agtgcagca  tctctcatc  cacgtcgta  24360
tttttgagt  gatgtgaca  cggaataac  ataacaaaa  aaaaaaaac  gaatggctt  24420
agtccatgg  actgaacat  catgacatt  gggctgact  caggcatgg  ttgatccag  24480
ggctccaac  ttatcggga  cctgtgtca  tgtgcatag  tgggacagc  gtctcccat  24540
gcagcaaac  aacaccgtt  cccagcagc  gtaagcttt  atcctccca  ctcagcaac  24600
ccagccaat  ccttctgct  aattacagc  tgtctcagg  ctcattctc  ttggccagg  24660
ttaggtgac  tgacatccc  gatataatc  ctatgttct  gctggaata  tctgattgg  24720
caatcttgg  tcacatgac  tttccattt  aatcttttt  ttttttttt  tttggaggg  24780
ggagatgga  tctcattat  ttgctcagg  tggagtgca  tggcatgat  ctggcttac  24840
gcaacctcc  cctcccggg  tcaagtgat  ctccttcct  agcatccaa  tagctggga  24900
tacaggcgc  tgccaccac  cctgtctaa  ttttatatt  ttagtagag  cagggtttc  24960
gcatgttgg  caggatggt  tcaatctcc  gacctcgtg  tccacccgc  tcggccgca  25020
aaagtgctg  gattacagg  atgagccac  gcgcctggc  taatttttg  atttttcta  25080
agatggtat  tcaccatgt  ggccaggct  gtctcgaac  cctgacctc  tgatctgcc  25140
gcctcagtt  cccgaagtg  agggattac  ggcatgaga  accacgcct  gcctgttgt  25200
gttttgaga  gggggtctt  ttatgttgc  caggctggt  ttgaactcc  agactcaag  25260
cacccgccc  cccttggct  cccaaagtg  tgtgattac  ggcatgagc  actgcactg  25320
gccaaatgt  ttttgtttt  gtgcttttc  ccgtcccca  cgcccccag  tgccggcct  25380
gggagcctg  tgttggcag  actgtgagt  actgttggg  tgtttaagg  cctttaaaa  25440
gtgttccca  catttcccg  gggctgtgc  ctaattagg  gattagtag  ctgactcct  25500
cagatgtct  cctggggat  ccgggggac  gtggggagc  gggaagtgt  gctgcctac  25560
tggcctgcc  tccagaggc  ccattgcct  cccatagac  cccaagggg  aagtgccag  25620
ctcagcttt  cgacaggtg  gctctgtgt  tctggacaa  tggctgtcc  tctctggtc  25680
catctatct  ctttcccat  tatctagtg  gctgtgggc  tatactatg  tcctgtagg  25740
gccagagcc  ctattcttg  tctgttact  agatacctc  aacctctcc  cccagcaaa  25800
taatcatcc  ctttatcat  aatggctga  gtttaccaa  ttttctcag  gccccagca  25860
tgatccagg  cttcaaggt  ggcgcagtt  ttactactt  ttttttttt  tttttttta  25920
atttcagag  cagggtctg  ctctgtccc  caggctgga  tgcagtgca  gatcatagt  25980
cactgcgcc  ccacctccc  ggctcaaat  atcctccca  ctcagcttc  tgagtagct  26040
ggactacag  tgcacacca  cacacctgg  taattttaa  tttttttgt  gagaagggg  26100
ctccctatg  tacccagac  ggttttgaa  tactgggct  aatcgatcc  cctgcctcg  26160
cctcccaaa  tgttgggat  acatttgtg  gccactgta  ctggccaaa  tttgtgggg  26220
tttttgttg  ttgtttttt  gagacagag  cttgctctg  tgcccaggc  ggagtgcag  26280
ggcatgatc  tggctcact  caacgtcca  ctcccaggc  caagcaatt  tcctgcttc  26340
gcctcccga  tagctggca  tccagctgc  catgaccac  cccagctga  ttttgtatt  26400
ttagtagag  tggggtttc  ccagtttgg  caggctggt  ttgaactcc  gacctcaaa  26460
gatccgccc  cctcagcct  ccaaagacc  ggggttaca  gcatgagcc  caaaaattg  26520
gtccaatct  tgctcacac  agagaccag  ataaactcc  aatgggcca  acagcgtaa  26580
ccagggggc  ccagctcct  ggactcacc  cctctctcc  tccccactg  gggtgtgga  26640
ttcaatgtg  acagcctcc  agacccagt  gggcagatg  tcatgggac  cagagtctc  26700
tgggggggt  cgtggaatc  cataaccca  ggggtctca  ccagggtga  tctgctccc  26760
gggggcact  ggtgatgtc  ggggacatt  gtggttgtc  caatggtgg  tactcttgg  26820
atggagtgg  tggaggcca  ggatgctgc  cagcaccct  cagtgccca  gacggcttc  26880
tcccagaga  ctatctggc  ccaaatgtc  acagcggcc  ggggagaga  ctcattcca  26940
agctcgata  ccaccaacc  tgcatggtt  cttaggttt  cactgagat  gatggaaac  27000
ggccaggct  taattaacc  cagcgcttt  ggaggtcga  gcgggagga  tgattgaac  27060
caggaggtc  aggctgctg  gagctatga  cgcggccct  cattccagc  taggtagca  27120
tgacaagct  tagatagat  gatagatag  tagatagat  gataaaaat  agatgaaag  27180
tgcatttcc  cagttgccc  ggccacggt  caggggctc  gcagcccac  agtgaccac  27240
acgtgggac  ccacggagc  agaatgtag  cgatgtggc  gaaagtcct  gcgggccgc  27300
cagcgcgga  acctccccg  gtgcaaacg  tccccgccc  ccacccacg  ggcgcccgt  27360
ccgccggcc  ctgttccac  gatgcccac  cgggggcag  gtgtcatca  gatctcgcg  27420
accttggct  aggtcgcct  cacctgccc  ctccccagg  gggtgagcc  ggccgctgg  27480
ggtttggag  cagcagccc  tcggcttac  aatcctttg  gagcacctg  tgtgtgcca  27540
gctgtgtgc  gggacagct  agtaaatca  agagtctta  ccatgcttt  tcaccgtgg  27600
ctttacggg  gggatggtt  tctggggtg  ggctgtcct  ggcactgca  ggtgctgag  27660
agcgtccct  gcctccact  actccatgc  aggcgcacg  cccagtcgt  acaaccaca  27720
atgtcccca  acatcaccc  gtgccccct  ggagcagaa  catcctcca  gttagaatc  27780
ctgggttag  ggattccgc  gacccccaa  agactctgg  tcccatgat  ctctgccct  27840
ctgaggtcc  aggtggcta  acacattga  atccacacc  tgagtgggg  gggagagag  27900
aggtgaatc  caagggtcc  catggtttg  accatctgc  ccatcggga  cttattctg  27960
tttctggtg  gagcaggga  cagactcaa  tttcccccc  aataattaa  taagagatc  28020
ccattctag  cactgtgga  attcaaggc  ggattgtcc  ctaggatga  gccgccttg  28080
gcactgcag  gtcctgagc  gagtccctg  catccaccc  ctccatgcc  gcagcacct  28140
ctccaagtc  cgacaacca  aaatgtccc  agacactgc  gtcaatctc  tgatcaagg  28200
gtgcaaaat  accgccacc  gagaattcc  ttctttttt  tttaatttt  tttgagaca  28260
agtctcgct  tgtcaacca  gctggagtg  agtggcacg  tctcggttc  ctgcaagct  28320
tgcctccca  gttcatgcc  ttctcctgc  tcagcctcc  gagtagctg  gactacagg  28380
gcccaccac  acatccagc  aattttttg  atttttagt  gagacgggg  ttcaccatg  28440
tagccagga  ggtctcgat  tcctgacct  gtggtccgc  tgcctcagc  tcccaaagt  28500
ctgggatta  aggcgtgag  caccgcagc  ggccaaaaa  tcctttcta  tgaatcaac  28560
catcacaca  ataaatatt  atttgttta  tttattttt  tttagtttt  ttgagatgg  28620
gtcttgctg  tgtcgccca  gctagaatg  aatggcacg  tctcggctc  ctgcaacct  28680
cacctcccg  gttcaagtt  ttctcctgc  tcagcctcc  gggtagctg  gattacagg  28740
acctaccac  gtaccctgc  aatttttgt  tttttagta  agacgaggt  ttgccacat  28800
ggccaggct  gtcttgaac  cctgacctc  tgatccacc  acctcagcc  cccaaagtg  28860
tgtgattac  ggtgtaagc  accgtgccc  gcccacaca  aaatatatt  aaattatga  28920
ataagcagt  atggccagg  gcagtgtct  acgcctgta  tcccagcac  ttgggaggc  28980
gagatgggc  gatcacgag  tcaggagat  aagaccatc  tggctaaca  agtgaaacc  29040
cgtctctac  aaaaataca  aaaaattag  cgggtgtgg  ggcgggcgc  tgtagtccc  29100
gctactcgg  aggctgagg  aggagaatg  cgcgaaccc  ggaggtgga  tttgcagtg  29160
gctgagatc  cgccactgc  ctccagcct  ggtgactaa  tgagactcc  tttcaaaag  29220
aagaaagaa  gaaagaaag  gagagagag  gagagagag  gagagagaa  gaaaggaag  29280
aaggaagga  ggaaggaag  aagaaagga  ggaagaaag  aagaaagaa  ggaagaaag  29340
aagaaagaa  cagttatat  aggtgaggg  gctgtaaac  tttcttgac  atcacatct  29400
cacccaggt  aaagtgatt  tcctgcctc  gcctcctga  tagctggga  tccaagtgc  29460
cgccaccat  cctggctaa  ttttgtatt  tttagtaga  atggggttt  gccatattg  29520
ccagtctgg  ctcgaactc  tggcctcag  tgatccgcc  gcctcggcc  cccaaacac  29580
catatacac  catgtactc  ggacagagg  ttaagtacc  gcataaccc  aataaaaat  29640
gcacaagat  actcttcgc  ctgcaaagc  ccacgcact  tgatgtttc  tattctact  29700
catttaaaa  atatatatg  gtcatgatc  actgaattg  tttctccac  cacagactg  29760
aaaaaataa  aattaaaat  gcgactggg  atcacgcac  ccagaaaca  ccccaggcc  29820
ttccactgt  gaaaaaaat  aatgagcca  gcaccaagg  tcacacctg  aatcccagc  29880
ctttgggag  cctaggtgg  cagatgacc  gaggtcagg  gttcaagac  agcctggcc  29940
acatggtga  acaccatct  tattaaaaa  gcaaaaatt  gccgggtgt  gtggtggga  30000
cctgtaatc  cagctactc  ggaggctga  gcaggagaa  cgcttgaac  tggaaggcg  30060
aggttgcag  gagccgata  cgtgccatt  cattccagc  tgggtgaca  gaacaaaac  30120
ccatctcaa  aaaataaat  aaaaaaaaa  tagtggtag  ccggcacgg  ggctcacac  30180
tgtaatctc  gcactttgg  aggctgagg  gggaggata  cttgagccc  ggaggttga  30240
gctgaagtg  gccatgatt  caccactgc  ctccagcct  ggtgacaga  tgagactct  30300
actcaaaag  aaataaata  atataaatg  ctccttctc  ctttattta  ctgtctatt  30360
tccaaatag  ttcatggat  ctctctctc  ctctttttt  tttttttag  tggagtttc  30420
ctgtcgccc  ggctggagt  cagtggcat  atctcagct  actgcaacc  ccgcctcct  30480
ggttcaagc  attcttgtg  ctcagcctc  ctagtacct  gaattgcag  catgcatca  30540
cacacccag  tagtttttg  atttttagt  gagacgaga  tttgccatg  tggccaggc  30600
ggtctcgaa  tcctgatct  aggttatct  cttgcctct  cctcccaaa  tgctgggat  30660
actgcagcc  cccgagtag  tgggactac  ggtgtatgc  atcatgcct  gcagatttt  30720
ttttatttt  ttgtggaga  aggttctcc  tgacaagcc  aggctggtc  tgaacgctt  30780
gcctcaagt  atgtgcctg  cttggcctc  caaggtttt  agactacag  catgagaca  30840
cttgccagg  ccagaagga  gggtttaga  ggagtaaca  ggatagaca  agttacatt  30900
tgtagggac  gagctcaca  tgtgggtag  cagttccag  cagaaggca  aggctgtgc  30960
aaggccctg  ggtaggact  tgcctgact  gttagagga  cactaagga  acctgtgtg  31020
ctggaggaa  gggagacag  gaggagggg  ggacgggga  gggctggtg  aggcccttg  31080
gggccatgg  gcggacttg  gcttttcct  aaggaaggt  ggagccatg  agggctgtg  31140
gccgaggag  gacaggccc  gactcagat  tgaattcag  tatgaaggc  gagtgtggt  31200
gctcatgcc  gtaatccca  cactttggt  ggctgagtg  ggaggatca  ttgaggtca  31260
gagttcgag  ccagcctgg  caacatggt  aaaccccgg  tctactaag  tatacaaaa  31320
ttagccaga  gtggtggca  gcacctgca  tcccagcta  tcaggaggc  gaggcacaa  31380
aatcgcttg  acccaggag  ggaaggttg  agcgagccg  gattgtgcc  ctgtactcc  31440
gacagggca  cagaataat  ctccatcag  aaaataaat  cataaataa  ataacaata  31500
ttcagtgtg  ctttaacat  aagaggctt  tccactaaa  ccatgtctg  agaaaccgg  31560
cacgagctg  ccctggctg  gcgtgggga  gtctgtgga  ggtcagacc  ccctgggct  31620
ggaatgggc  tgtttcaaa  gcagcttcc  ggggctggc  ctccgcaca  tctaattca  31680
caaaggcgg  gcagagtct  agctgtgac  ccgtgtccc  ggtgtttcc  gaatcat  31737



<210> 2931
<211> 197
<212> PRT
<213> Homo sapiens
<308> AAC72103
<400> 2931

Met Met Phe Pro Gln Ser Arg His Ser Gly Ser Ser His Leu Pro Gln 
  1               5                  10                  15
Gln Leu Lys Phe Thr Thr Ser Asp Ser Cys Asp Arg Ile Lys Asp Glu 
             20                  25                  30
Phe Gln Leu Leu Gln Ala Gln Tyr His Ser Leu Lys Leu Glu Cys Asp 
         35                  40                  45
Lys Leu Ala Ser Glu Lys Ser Glu Met Gln Arg His Tyr Val Met Tyr 
     50                  55                  60
Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Ala Glu 
 65                  70                  75                  80
Ile Val Lys Arg Leu Asn Gly Ile Cys Ala Gln Val Leu Pro Tyr Leu 
                 85                  90                  95
Ser Gln Glu His Gln Gln Gln Val Leu Gly Ala Ile Glu Arg Ala Lys 
             100                105                110
Gln Val Thr Ala Pro Glu Leu Asn Ser Ile Ile Arg Gln Gln Leu Gln 
         115                120                125
Ala His Gln Leu Ser Gln Leu Gln Ala Leu Ala Leu Pro Leu Thr Pro 
     130                135                140
Leu Pro Val Gly Leu Gln Pro Pro Ser Leu Pro Ala Val Ser Ala Gly 
 145                150                155                160
Thr Gly Leu Leu Ser Leu Ser Ala Leu Gly Ser Gln Ala His Leu Ser 
                 165                170                175
Lys Glu Asp Lys Asn Gly His Asp Gly Asp Thr His Gln Glu Asp Asp 
             180                185                190
Gly Glu Lys Ser Asp 
         195



<210> 2932
<211> 1356
<212> DNA
<213> Rattus norvegicus
<308> L14462
<400> 2932

cccggagct  tcgatcggg  acaaagcgc  gccgcccgc  ccccccgag  cgcccgagc  60
ggggccagc  ccccgcgac  gacatgatg  ttccgcaaa  ccggcactc  ggctcctcc  120
acctccccc  gcagctcaa  ttcaccacc  ccgactcct  cgaccgcat  aaggatgag  180
tccagctgc  acaagcgca  taccacagc  tgaagctgg  gtgtgacaa  ctggccagc  240
agaagtcag  gatgcaaag  cattacgtc  tgtactatg  gatgtctta  ggattgaac  300
tcgagatgc  caaacaggc  gaaattgtg  agaggctga  tgggatttg  gcccaggtt  360
taccctatt  gtcccagga  catcagcag  aggtcctgg  agctatcga  agagccaag  420
aggtcacgg  tcccgagct  aactccatc  tccgacagc  gctccaggc  caccagctg  480
cccagctcc  ggcgctggc  ctgcccctg  caccgctgc  tgtcgggct  cagccgcca  540
ccctccctg  ggtcagcgc  ggcacaggc  tgctgtcac  ctctgctct  ggctctcag  600
cccacctct  caaggagga  aagaacgga  acgatgggg  cacccacca  gaggatgat  660
gagagaagt  cgattagct  ctggggaga  ggaggggga  gggggatac  aggggagac  720
ggcacagag  gcacagtgt  ctgagggcc  cactgcaca  agctcggtc  ctacccaag  780
ttccacctc  agtcctggt  ccagctgtg  accctgggc  taggagacg  cagagggac  840
gcccaggct  cagggaaaa  tccccacct  caacatttc  ccgggctac  gccaccaat  900
tcggcccag  atgtacaca  cgctagccg  ccctttcca  cctgtgcac  ccgaatttg  960
cccctttcc  cttctctgc  tcctgcact  cacacctgc  aggcccaga  ccctccccc  1020
agctcaccc  gctctggtt  cctcaaccg  ggaaagaaa  cattggctc  ggactgcag  1080
gggggtggg  accccacaa  cttccctct  cccttcccc  aataaacgt  agggttaaa  1140
gtcggtttg  ttattattt  tttttcgtc  cagtactct  tagctacca  ctaagagag  1200
aaaagaagg  agccctgga  cgagcgagg  tctgtctgt  catatagtt  gatttttct  1260
gtcgcctcg  tttgcaccg  gaggtggag  gccgctgta  tgagggtgg  gtctagctg  1320
gccttcaaa  taaaaacat  aaaaggtca  aaaaaa  1356



<210> 2933
<211> 197
<212> PRT
<213> Rattus norvegicus
<308> Q06195
<400> 2933

Met Met Phe Pro Gln Ser Arg His Ser Gly Ser Ser His Leu Pro Gln 
  1               5                  10                  15
Gln Leu Lys Phe Thr Thr Ser Asp Ser Cys Asp Arg Ile Lys Asp Glu 
             20                  25                  30
Phe Gln Leu Leu Gln Ala Gln Tyr His Ser Leu Lys Leu Glu Cys Asp 
         35                  40                  45
Lys Leu Ala Ser Glu Lys Ser Glu Met Gln Arg His Tyr Val Met Tyr 
     50                  55                  60
Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Ala Glu 
 65                  70                  75                  80
Ile Val Lys Arg Leu Asn Gly Ile Cys Ala Gln Val Leu Pro Tyr Leu 
                 85                  90                  95
Ser Gln Glu His Gln Gln Gln Val Leu Gly Ala Ile Glu Arg Ala Lys 
             100                105                110
Gln Val Thr Ala Pro Glu Leu Asn Ser Ile Ile Arg Gln Gln Leu Gln 
         115                120                125
Ala His Gln Leu Ser Gln Leu Gln Ala Leu Ala Leu Pro Leu Thr Pro 
     130                135                140
Leu Pro Val Gly Leu Gln Pro Pro Ser Leu Pro Ala Val Ser Ala Gly 
 145                150                155                160
Thr Gly Leu Leu Ser Leu Ser Ala Leu Gly Ser Gln Thr His Leu Ser 
                 165                170                175
Lys Glu Asp Lys Asn Gly His Asp Gly Asp Thr His Gln Glu Asp Asp 
             180                185                190
Gly Glu Lys Ser Asp 
         195



<210> 2934
<211> 31737
<212> DNA
<213> Homo sapiens
<308> AC005944
<400> 2934

gatccgtcc  cctcagcct  ccaaaatgc  aggattaca  gcttgaacc  ccgcgcccg  60
cctgctttt  ttttttaat  aagacagtg  ctcgttctg  agccaggct  gagttcagt  120
gcgcgatca  ggctccttg  agcctcaaa  tccggggct  aagcaatcc  cccgcctca  180
cctccagag  agctgggac  acaggcaca  aacaccacg  ctgactatt  tttggattt  240
tagtagaga  agggttgtg  catctcagc  aggctggtc  tgaactcct  gcctcaagt  300
atcctccca  cttggcctc  caaagtgct  ggattacag  catgagcca  tgcactccg  360
cttattttt  ttttttgta  agatgatgt  ttcctatgt  gcccaggct  gtcttgaac  420
cctgggttc  agtgattct  caatctcag  ctcccaaag  gctggggtt  caggtgtgt  480
ccagcgtgt  tggctggac  cagggtctt  gtgtgggaa  tggggtagg  atgttgcga  540
acccaccct  cttttggtg  gtgagagtc  gaggaggcc  tcagaaaag  gacttctag  600
gagtctcag  gaattagaa  gcctgggag  ggaaataaa  agaaccctg  tccaggcag  660
gggaacagc  tgtgaaaag  cctcaaggc  agggacagc  agatgtttc  ccttggctg  720
agcctgttg  gtaggagtg  aaggaggga  gggtagggt  tcctgggcc  aggtgaaga  780
tttcgaatt  attccaagg  cagtgagag  caaagataa  ctttttttt  ttttttttt  840
ttttgagac  gaatctcac  ctgtcagcc  cgctggagt  cagtggcat  atcatagtt  900
actacagcc  tgacctcta  ggctccagc  atcctcctc  ctcagcctc  caagtagct  960
ggaccacag  tgcacaaca  tatgcccgg  tgattcttt  ttttttttt  tgagacgga  1020
tcttgctct  ttgcccagg  tggagtgca  tggtgcgat  tcagctcac  gcaagctcc  1080
cctcccggg  tcacgccat  ctcctgcct  agcctcccg  gtagctggg  ccacaggcg  1140
ctgccacca  gcccggcta  ttttttgta  ttttagtag  gacggggtt  caccgtgtt  1200
gccaggatg  tctcgatct  ctgaccttg  gatccaccc  ccttggcct  ccaaagtgc  1260
gggattaca  gcataagcc  ccgcgcctg  ccataattc  tatattttt  tagagatag  1320
gtctcacta  gttgcttag  ctggtcttg  actcccagc  tcaagcgat  ctctcacct  1380
ggcttccca  agtgctgag  ttacaggtg  gagccacca  gagcagcct  tcttttttc  1440
tgactgtgt  gtattctgc  gtgtgacca  gtcacaatc  atctatttg  ttgggggca  1500
ttatgacaa  ttacagcag  tctaaacac  cttgttcag  tctgttttt  tgttttgtt  1560
tgttttgtt  tgtttgaga  ggagtttca  tctgtcacc  aggctggaa  gcagtggcg  1620
aatctcagc  cactgcaac  tccgcctcc  gggttcaag  gattctcct  cctcagcct  1680
ctgagtagc  gggactgca  ggctgccac  acacccgac  aatttttgt  tttttagta  1740
agatggggt  tcactatgt  ggccaggct  gtcttgaac  cctgacctg  ggtgatcca  1800
tcacctcgg  ctcccaaag  gctgggatt  caggcgtga  ccaccgcgc  tggccaatt  1860
ttcgggtct  tttgatgga  tcatatgac  tttccgttg  gagatggat  caagagggg  1920
attgctgga  tatgtggtg  caagtggcc  tctgaagta  aggtaagag  ttacccttg  1980
tggccgggc  cggtggctc  cgcctgtaa  cccagcact  tgggaggcc  aggcgggtg  2040
atcacgacg  caggagatc  agaccatcc  ggctaacat  gtgaaaccc  gtctctact  2100
aaaatacaa  aaaaaatta  ctgggcgtg  tggcgggcg  ctgtaatcc  agctacttg  2160
gaggctgag  caggagaat  gcgtgaacc  gggaggcag  gcttgcagt  agccgagcc  2220
agattgtgc  actgcactc  agcctgggc  acagagcaa  actccatct  aaaaaagaa  2280
aggaaataa  aagaattta  ccttgccaa  gggtgtgcc  aggcgtgtt  aggtttcaa  2340
aagggtaaa  gtcagcagg  gatgatccc  tgcaactgg  atttttaga  gcactttgg  2400
tgcagtgga  atggggtgg  acctgccag  aggctggtg  gatcagcca  ccctgtccc  2460
tccactccc  gccctctcc  cagggacat  agacatttt  cccaatgtc  gctgtccat  2520
tccaccctt  tcagctccc  tcagctcgg  cttcctcct  ccgtgaagt  cctccagag  2580
agaaatggc  atctcccat  tgctgggtg  gcagcaaca  gttcccttg  cccaagtcc  2640
agaggagcc  ggggctgag  ccaagatgg  aaaactggg  gcaatcccc  ttccttctg  2700
cttccccac  gctggtgca  cttgggtga  gcggtgggg  ttggggggc  tctggctgt  2760
ccttagagg  tggaggctc  gctggggcg  gtcagtgtt  tctctgagt  tactggcca  2820
gcacggggg  tcacgcctg  aatcccagc  ctttgggag  ctgaggcgg  aggactgct  2880
gagcccagg  gtttgagac  tgggtaaca  ggtgaaacc  catttctac  aaaaaaaaa  2940
aaaaaaaaa  tatatatat  tatatatat  tatatatat  tatatatat  tatatatat  3000
tatatatat  caaaagatt  ggcgagtat  gtggtgcat  cccactgtc  cagctcagg  3060
ggctgaggc  gaggtggga  gatcacttt  gctcaggga  gttgaggct  cagtgagct  3120
tgatcacac  actgcactc  agcctgggc  acagagtga  accctgtct  aaaaaaaca  3180
acaaacaaa  aaaaaaaac  cacccagaa  cgaaaagaa  tgtacctgt  tgggcactg  3240
ggcctcctc  ttctctaag  gaagagaat  tcctttagg  cttcagatc  cgggtgcag  3300
aatcagctc  gccactgac  cacttattt  attattaaa  aaaaatttt  ttttaggag  3360
tggggtctt  ctatgttgc  caggttgtc  ttgcactcc  ggcctcagg  aatcctccc  3420
cctcagcct  cccacttac  agcttaggg  tcccttcgc  tttttaagc  cccttaact  3480
cctgtctaa  catcaacca  ctgggccat  ctgtgtgac  tgaagtctt  agctcaccc  3540
ctctgggct  ggcatcaga  cagtgtagg  caaatgcag  agcgtgacc  accaactct  3600
tttttttga  acagcgtct  gttctgtcg  ccaggctga  gtgcagagg  atcatctca  3660
ctcactgca  cctctgcct  ccgggttca  gcaattctt  tgtcccagc  tcctaagca  3720
ctggaatta  aggtgcacg  caccatgcc  ggctacttt  tgtattttt  ttttttttg  3780
gatggagtt  tgctcttgt  gcccaggct  gagtgcagt  gtgcgatct  agctcaccg  3840
aacctcctt  aattcaagt  attcttctg  ctcagcctc  taagtagct  ggatcacag  3900
tgcccacca  cacgcccag  ttttttgta  ttttagtac  gacagggtt  caccatgtt  3960
gccaggctg  tctcgaact  ctggcctca  gtgatctgc  tgcctcagc  tcccaaagt  4020
ttgggatga  aggcgtgag  cacaccgca  cgggccaca  ctaggaact  ctgatgttc  4080
aggaggatg  ctcacattg  aaggaaccc  gtcctcccc  gggggcagc  acaacacag  4140
ggcagggac  cagcaccga  gcttctcac  tctttattg  aaaggcaca  ctaagccca  4200
ccttgatac  gcattttcc  cttctctct  tagagatca  acgattgaa  acgagataa  4260
ctgactata  acagacaca  gtgtgggtg  tgctttttt  taaaaacac  tttgtcttt  4320
ttttttttt  atatcccct  tcttaaaag  caagctagt  tactggaaa  agaaaaaaa  4380
aataataaa  taaaaacca  gacaacttt  gtaccctca  ctttatttg  gaaggggag  4440
gggaatcct  ggtcgccca  cctcaccct  ctcctccca  ctcagctaa  ctcgtccct  4500
gtgcccccc  ttttgtggg  gatgggaga  gaccaggtg  gcgtggagg  gtctggaac  4560
agcagaggt  gtgagtggg  caggtggag  tgggagcat  cctgggacc  ggggtcggg  4620
gagactcgg  gtgcccagg  cgggaaagg  gcagctagc  ttgcgtgca  gcagtacca  4680
ggtgagagg  ctgtggccc  ggcagactg  cggttacac  tgttcaaaa  gggggaagg  4740
ccggggctg  tgcgcttcg  gaggtcttg  tcccttggg  cctggtctc  catctgacc  4800
tccaggcct  agcttgcct  acatgtcag  gcaggtatc  acctaacca  gctgcaggg  4860
aggaggagg  aagccggga  tggggtagg  agaaagcta  aggtggcct  caagctggg  4920
tggggcccc  gccggcggc  accataaat  ctatgggag  ttagccaat  ccgagctcc  4980
ctgtgtctt  tgctaaaca  tcctttctc  ccgtgcctc  gtctcccct  tgtcccccc  5040
cccaacctc  ctgtcccgg  cccctgcta  tccgacttc  cgccatcat  ctcctggtg  5100
gtgtcacca  cgtgcccgt  cttgtcttc  ttggagagg  gggcctggg  acccagcgc  5160
gacagcgag  ggaggccgg  gcctgcgct  accgccggc  gcgaaggcg  ctgcagccc  5220
acgggtagt  gggtcaagg  cagggccag  gcctgcagc  gggacagct  gtgggcttg  5280
agctgctgc  gcagggcgg  ggaggggaa  attagctgc  tggggccca  ctgtccccc  5340
cccacccgc  caggtcccc  tacatactc  gatgataga  ttcagctcg  gagcggtga  5400
ctgcttggc  ctctcaatg  ctcccaaga  ctgctgctg  tgctggaag  gggtcgggg  5460
agaggagag  cagtgattc  tcctgatcc  gggagagga  agggggacg  ccctgaggc  5520
aggaggagc  ccactacca  gtgggccat  atgtctgct  ctcccagtg  ttttcaacc  5580
catcagaaa  caccctccc  ctctccaac  gcttccttt  accaagctc  tctcttcgt  5640
tggccaaca  agacaaatg  aaaagtgca  aaaacaatt  aaagggttt  gtgctaagt  5700
gttaggaaa  agcttttga  tgagcccgg  agaaaccct  gatcctgac  tatcctatg  5760
gcacagcca  ctgcaaaga  gtgaaacat  tgaatgttt  tgcagtaca  aacctgccc  5820
actgtacag  gacgtcctg  tcctaggag  tccaagact  tgccctgag  ctggccaaa  5880
tgagccctt  tcctaccat  gctggggag  gcccaatga  ttctggcag  gctggctgg  5940
gaatgggct  agattcagg  cagttcctc  ctgagctct  cccaaacac  tgactctgt  6000
gccagcaga  gctagaatc  accaatctc  ctttttgcc  tggctacca  gaagcctct  6060
ttctgaagg  ctccaagtg  ccttttctc  agggctttc  ttgggtcct  ctaagactt  6120
tccctgggc  aagcagggc  cccaaagga  cctgagata  ccacaggga  tgaagagga  6180
gttacaaac  tttgacagt  aacttggca  ggacaggag  tgggcctta  atggccctg  6240
ggaggggcg  cctcgcatc  tgagcctca  aacccaaga  aggagaaga  gagctgggc  6300
tcaggttca  ctgggtgtg  gtgtgcatg  ggtaatgtg  gctcaggat  acgtgtgcc  6360
acgtgtagc  gcacattcc  gcatgcgtg  ccctgtgct  tctgcacac  cgtgtatcc  6420
tgtctgcat  tgtgtatct  ccgtgtgtt  atgtgctcg  gcctatctg  gtggctgtg  6480
ccatgtgtg  ccaccctgt  ctacccctt  ccccacaat  ccctaacac  ctctagtcc  6540
tggtcctgt  cagcccgca  ggcctggag  aggatgtct  aagagggtg  aaggaggaa  6600
agagatgag  aaaaaacat  cctggtgca  tttaggccc  tctgacatt  ctacctatg  6660
catgactca  tccagctgg  aattccaga  cagggtgag  cccgccccc  acacgcctg  6720
acccctgga  tgtctctgg  ccggggatt  ttctgcaca  gccggctct  gtgttcaga  6780
ccagggagg  ccagagagg  gaggcgtgt  ccctggggc  cccagcaca  cacccaaga  6840
ggctgcagt  gacaggggc  gggcaagtg  ggggccccc  cacaacccc  ccccaaggc  6900
ctggctctt  cctcttggg  gaggtaggg  aggacctgg  cacaaatcc  gttcagcct  6960
ttgacgatc  cagcctgga  cacacagat  aagccggct  cagtcctgg  cgggtggca  7020
gtgcaggct  gccacagga  gcctgcgcg  ggcccggcc  agccctgcc  cttgcggct  7080
ctaagaggg  ctaggtctg  ccagggtgg  atgagcaaa  ccgtgttcg  gcccgaggg  7140
agccagtca  tggcaaagg  ggggctgga  accggctgt  gcctgcagc  tagagtgag  7200
taagtgcag  atgaggcca  actgcacat  cctcggggg  cggccactc  ggcccctgg  7260
aggtagtaa  cgcttgtgc  aatgtaggg  gggctgggg  ccgtaggct  tggggaagg  7320
ctctgcccc  ccccaccac  gggagaaac  ctcccaggg  ggcctgaaa  agaggcggg  7380
cggggggga  gagagcggg  gcttgggga  ggcttagga  gtaacagga  aaccgggct  7440
gcttggtgc  cagccgagg  ccggccgct  cctgcctgg  ggtgcccaa  gcggggctg  7500
aggtggggg  aggaggggg  aggaggagg  ggaggagga  gaggaggag  tgggcgtac  7560
tgtttgtgc  tctcgatgt  caagccgta  gacatctcg  agtactgta  gggggagag  7620
gagggggag  gggagatgg  ggtggggaa  gatgggggg  cacggagac  aagagatag  7680
ggagtggca  agacagaca  aggggggag  cagcaagag  cagctgagg  caggaaaga  7740
aggagaggc  ggtgggagg  aaagaggag  gagagacgc  cacacccag  atcccagcc  7800
gccctggag  ggggcaggg  gccgctggg  ctgcggatg  agactgggg  cactttagg  7860
ccctagccc  ggcctggct  ctcccccac  ccatgtgca  cgcgagaac  cgcattcca  7920
ggctcctaa  cttgtatct  tctatgtct  gtctgcggg  gggcccaga  gccagggaa  7980
tttgcctgc  taggtataa  cagtgaggg  taaacaaag  ctgctggct  tggggccag  8040
agctacccc  accccaagc  ccagatctc  ccctgcccc  cccctgctc  aaaccctcc  8100
atggctccc  gtcacccct  ggggaaaac  aagttcatt  ccaggcctt  acgtagttt  8160
tctgtctct  tctggtgaa  tcctactca  cctgcaaga  cccagctgt  tgccccatt  8220
ctccatata  tcttcctca  gcaggtcct  ggtccctct  tctgacccc  gccctattc  8280
tctggctgg  agggtcagg  tctggctct  cctccccca  agtctggga  atttgggta  8340
tgggctgag  ccccagcat  gctgctcga  ggccaggcc  agggtgggt  agggagggg  8400
tttttgatg  agaaatcgt  acctggcag  tacaaaacc  agcaagtgg  tctggcagc  8460
gcaatgcag  gtcacacat  agccccccg  aatgggtag  gctcagacc  cctcccaca  8520
gcttcttct  tgagctcgg  cccaaaggg  ttaagcgtg  ggacgctgg  accttggcg  8580
tggggaggg  ctcggctgc  cccccacgt  agttcctgg  tgttggctt  cacagccgg  8640
gagcctccc  ctcctccct  ctccgctgc  aaggacagc  gggggacct  gcagggccg  8700
tctgcaacc  ggcggtttg  cacctcggc  actgcctcg  ccatctgcc  ggctagcga  8760
gcaggctca  cccagcagg  gccggctga  tggagaaca  gccccgatc  tcgcgcttc  8820
caggggagg  ggccggggt  gagggagca  ctgcccgtg  tggagggga  gtggagggc  8880
ctgtcgccc  cccccaaca  tggacctgg  ggcggagtg  cgttaccat  acatagtga  8940
gctgcatct  tgacttctc  ctggccaac  tgtcacatt  gagcttgag  ctgaggagg  9000
acagggggg  gatggggtg  ttagtggcg  ctgggcggg  gccccccac  ctccgttat  9060
caggggagg  aactgaggc  ccaagtccc  tgtaagggc  agatcagcc  attctcaga  9120
ggtcaagca  taatttttt  tttaaattg  gacgggggt  tccctatgt  gcccaggct  9180
gtctcaaaa  ctcctgggc  caagcaatc  tccttcctc  gcctcccaa  gtgcttggg  9240
ttacagata  gagccaccc  ccgtgcctg  tcaatgaag  cgtaaactt  cataggggc  9300
gaggacatt  aattgaggg  cagggaagt  ggtaagagt  gagctctct  tgatgctgc  9360
gggagggga  agcatcagg  cccctgact  taagaaggg  gtgatgaaa  cacccttgc  9420
gatctggtt  gggggaaat  agcaacatt  tagtaacat  ataggaaca  cagaagtta  9480
agggggcac  gtaacgcta  ctctgagag  ctcacgagc  ttcacctct  acggtcccg  9540
cgaggcccg  aacgtcatt  tcacgctcc  tttatagat  acacagtgg  cacccagag  9600
gggtgagga  ctggctcaa  gtcacacag  caagcagca  cccaagctc  caaccacag  9660
ggaaaattt  ccagaccca  atagaacgt  caaagaggc  gagagggtc  ggggctgca  9720
ggcggctcc  ggctggact  cccaagggg  ccctagctt  atggggggc  tggacttcc  9780
aggcagacc  ctcagctcc  tcttagtcc  tcctaacag  cttttttct  tagctggga  9840
aaaacacac  atttctccc  ctccacctg  ccagtccgg  tggctgaca  cagagcttc  9900
tacaggccc  cccgggaag  atgagctgt  gggcgtttc  caaagcccc  atgagggcg  9960
catggccgg  gggaagaga  caggcagga  ggcctccca  tccaggaaa  gaactggtg  10020
tggtggtgg  ggaggtgtc  tttaaccta  ttaaatcca  cccagcaca  gggccctgc  10080
gacctggct  tggcttacc  gcttctgcc  tccccaccc  ctctcggac  gggttcaaa  10140
ctcagccct  cgtcttccc  gctgtgtga  tctaggcaa  ctccactac  tctctgggc  10200
tcatttcct  ctctgtgag  taccactaa  aacctcgca  ggtggggtg  agaagagtc  10260
atgaattca  acaagaaaa  ttctagaac  gtacctggc  tacagtaag  atcccataa  10320
tgcacatgg  tcttaggat  ccccaggaa  ctggcattt  gctccaccg  agaagagtg  10380
gccgggtta  ggatgcttt  gccgccacc  atttttctc  agttttctt  taaaatgtg  10440
atttgttgc  accattaaa  acaaaaaca  aaacaaaaa  aaaccgggg  tgggtgcag  10500
ggctcacgc  tgtaatccc  gcattttgg  aggccaagg  gggtggatc  cttgaggtc  10560
ggagtttga  accagcctg  ccaacataa  gaaagcccg  ctctaccga  aatacaaaa  10620
ttagccggg  gtggtggtg  acgcctgta  tcccagcta  ttgggaggc  gaaacagaa  10680
aatcgcttg  atcccaaag  tggaggttg  agtgagccg  gatcgcgcc  ctgcactcc  10740
gcctggcga  agagcaaga  tccgtctca  aaaaataaa  taaaataaa  aagaagttt  10800
actccaaag  ctgcatttc  ggcctttct  gaaaaatag  atggtctgg  cacccaggg  10860
ctgttacgc  tcgaacatc  ggtgtgtgc  tctgatatg  tagggtccc  cgttggaca  10920
caggaagcc  aggcccagc  gatggagac  ccaaagctc  gagagggct  ccggcttag  10980
agaggtcac  cagcactgt  accgccatc  gatcccttc  ctgtggaat  aggtcagcc  11040
cggggctca  caggcggta  ccaaccctt  atatcgagg  acccgcaca  aagcttctg  11100
ggcctgcat  gaaagctga  tccagcacc  tcgactgtc  gtgtctcag  ttgcccagc  11160
tgagaatgg  tacgacagt  ggacgacag  aaggatgaa  cacgaggag  cacgaacgg  11220
cttgagcac  cagggagta  ccaaaaagg  gggatattt  cagcagcaa  aacaaaatc  11280
agattcccc  ttctacttg  aggaaatcc  ggatccttc  aggaacact  ctggggtgg  11340
cacgcttca  tttagagag  gccccaagg  caaacgggg  tttgagcat  gcctgactt  11400
ctccagatt  ccaggcccg  cgtgcccct  cagagcagg  caggcgaga  cctatatcc  11460
taaaccagg  gagagacct  gtgcaaacc  cagccttgc  acttcctca  tgctatgga  11520
acccccgag  aaataacat  ataacatct  tgggcttaa  tttcttttt  tctttcttt  11580
ttttttttt  ttttttttt  gagacagag  ctccctgtt  cccaggctg  agagcagtg  11640
ctccatctc  gctcactgc  acctccgcc  cacgggttc  agcaagttt  ctgcctcag  11700
cacccgagt  gctgggatt  caggcgccc  ccaccacac  cagctaact  tgtattttt  11760
gtagagacg  ggtttcacc  tgttggcca  gctggtctc  aactcctga  ctcaagtga  11820
ccaccttcc  cggcctccc  aagtgctgg  attacaggc  tgagccacc  cgcctggcc  11880
gggcttaag  ttctttaag  gtaagagga  taaatagtt  cttcccctt  gataccgca  11940
cgtggcaag  tcttcagaa  cgccagatt  ctgaaagaa  cagcacctt  gagaatctg  12000
cgggtgctg  gaacccttt  tccaaaact  ggcaaagag  gagatgacc  ggctgcaga  12060
tgtttctgt  ttgggggtt  agggatggc  agtccgtgc  gtaactcca  ttgttggaa  12120
gtcttttat  caatggggg  cttgggggt  ttggggagg  gggaggggc  ctgaagcca  12180
acagctgaa  ctttgggca  attatttaa  tatttttgt  cctcggttt  ctcctctac  12240
aaatggggc  gtttaaaat  aatgaattc  gtatttgtc  agtgattag  tcagagtct  12300
gcatatatt  ttttcccaa  ctccaggcc  cagccttgc  atctgcgca  aagaaatgg  12360
gggactcac  ttctcggga  gcagggacc  ccagtcccc  agctcacct  tggtactga  12420
cttgcagta  ctgaaattc  tctttgatg  ggtcgcagg  gtccgaggt  gtgaatttg  12480
gttgctggg  taggtgcga  gagccctgt  gggatgggg  ggcccgggt  aggcccagg  12540
gtgggctgg  cccccctca  gggccggct  ggagggagc  gccgcgcag  tgcggcgcc  12600
cccctcctg  cccacttcc  gggcccgtg  ttacggccc  tggcgcgac  ccacccgcg  12660
ttcctgccc  ccgcctctc  cgggggaag  cgagcgggt  ggtgcgccc  gagccgccc  12720
gtcccccgc  acccccagg  agtgggggt  cgttttaag  cccgcccta  atggggggc  12780
gggtgcgcc  tctaccgcc  tccaaagcg  cgggaggga  tgcacatcc  aggggggta  12840
aaacgcgcc  tagggagcc  cctccccaa  ttggggggc  gcgattcct  cctgcaaag  12900
cctcttggg  gaggggtct  tctctcggt  ctcgaaatc  tccgggggg  cccaacccc  12960
gattcccag  gcccttcct  ggggacacg  tcttccggg  ggggtgcgc  tcggatcac  13020
ccccccacc  caggccccc  aaggatccc  gggctagag  tgcctcgcg  ggcttccgg  13080
gcgccccag  cccgaggcc  aggccgtcc  aggccctga  tgtcccggc  ggttggggg  13140
ggggggcgc  aagccggga  ctgcggcgg  ggggctcgg  gcccggaag  tggggtgga  13200
cgggaactg  agggggggt  tccgggggc  ggcggcagg  ggggagggg  gtcgcgccg  13260
gctgggagc  ggagaggga  gacagggcc  gggagttgg  gggggcgcc  ggccggagg  13320
accgggcct  ggggttggg  ggcgcgggg  cgggagccg  gggtcgggg  cgtagggcc  13380
ggatccggg  tgggggcgc  ggccggacg  gccccgctt  ccgaatgcc  gctttgtgg  13440
aacatcatg  caatcgcgg  ggggggcgc  ggctgcgcc  cggctgtgc  ccccggctc  13500
ggctgctgg  ggcgccggg  ggccgcgcc  ttgtcccgg  gccgatcgg  agctcccgg  13560
gccgccgcc  cctcccgcg  ccggcctcg  ccgcttcct  cgccccctc  ccgcgcgcc  13620
ggccccggc  cgccccggg  cccgcttcc  gcgcgcccg  cgcccctcc  cgcccctcc  13680
cgccgcccg  ctccccgct  cccggcccc  ccgctattg  ctaatggcg  cgacgccgg  13740
agtggccgc  gctcggctg  tgcggaggc  tcggctcca  ctgccgccg  ccgtgcccc  13800
tgcgcgccg  cgagggggg  gacgcgcgc  cccggggag  cctgcggat  cccacgccg  13860
cccgcctcc  cgtggcccg  ccgccgcgg  gaccttggg  ccggcccgc  cccgccccg  13920
gcagcggcc  ccgccaccc  ctcctaccc  gcagccggc  gggcctcgg  ttccccatc  13980
gtcaaagaa  agggacccg  ctgcccgcg  cgaagccgc  ggccctgct  tggcacgac  14040
tggacgcgt  ccacggacg  gctctgtga  cttggctct  gctgggcgg  ggttcttgc  14100
gagccttag  ttccttttc  gcagaaagg  agcggtaat  ccgccttcc  gagggaagc  14160
attcttgtg  cacatttat  gaacgccta  tgtgtgcca  gccccgctg  tccagggcc  14220
tggggtggg  cggggcggg  gtgggtccc  gccctggtg  tggtgcctg  agacagaca  14280
agacaaatt  acaagctga  ttcctggca  gtcagatgg  ggggacagt  ctgcagaaa  14340
accagccgg  agaatggca  ggtaggaag  tgcaaagtt  aagaggtgg  agggaggat  14400
agagacggc  tcctccacc  ctaaagcga  ctgaagaag  agggagaac  gggggatgg  14460
gtacagagg  agtcagagg  aggaccaac  ggtgcaaag  ccctggggc  ggactgtgc  14520
tggcagcag  gtgcccggg  ggaggtcag  aaggccgga  ggaggcagg  ccgggggct  14580
cgtgctttt  tccagggcc  ccccacccc  cagcagggc  tgtgcttgg  ttaatattt  14640
ctgctgcat  ttgagattt  taatcattt  tgaacaagg  gcctttgag  tttcttttg  14700
actgggccc  gctaactct  tagctggtg  agcaggcca  tccagcaag  acttgtggg  14760
cttggggag  acttgggat  ttgctctga  tgaggtagg  gccctggaa  gctgtggga  14820
gaggaggga  gggacctgg  ggttggttg  tttgttttt  gagatggag  ttcgctctt  14880
ttgcccagg  tggagtaca  tggcacaat  tcagctcac  gcatcctgg  ttcaagtga  14940
tcctgcctc  gcctcccga  tagctggat  acaggcacg  gccaccacg  cccgctaat  15000
ttggagttt  agtagagac  gggtttctc  atgttggtc  ggctggtct  gaactcccg  15060
cctcagatg  tctgcccgc  tcggcctcc  aaagtgctg  gattacagg  gtgagccac  15120
gtgatcagc  gtttgtttg  ttttgagat  gagtctcac  ctgttgccc  ggctggagt  15180
cagtgatgt  atgttggct  actgcagcc  ctgccaccc  gattcaagt  attctcctg  15240
ctctgcctc  tgagtagct  ggattacag  tgcgcatca  cacgcctgg  taatttttg  15300
atatttagt  gagacaggt  tcaccatat  ggccagact  gtcttgaaa  cctgacatc  15360
ggtgatcct  ccgcctcca  ctcccagag  gcagggatt  caggtgtga  ccactgcgc  15420
tggccctgg  cttgggctt  tgctctgag  gaggtggga  tcctggaga  ccgtgggaa  15480
aggagggat  ggacctggt  gcggttatt  aaggatccc  ctctctgcc  cgcagagaa  15540
aggtcccaa  gaggctact  aaataaggc  atgacatta  ggtccccct  tggcaggtg  15600
gaaacacag  ctcttcatc  tcgtcatcc  ctaggcagc  tgctccctt  aatgaatgc  15660
attgatttg  gccttgggt  ttcccatct  taaaataga  ttggaaccc  aggctcctt  15720
ccttggcag  taagggtga  agccttcag  gatcaagat  aataatctt  aaagcagtg  15780
tttaatatt  ttattaaaa  aaaattttt  ttttgaggt  gagtctcac  gtgtggccc  15840
ggctggagt  cagtggtgc  atctcggct  actgcaagc  ccacctccc  ggtttatgc  15900
attctcctg  ctcagcctc  cgagtagct  gggctacag  cgcccacca  cacgcccgg  15960
taatttttt  tatttttag  agagacgga  tttcactgt  ttagccagg  tggtctcga  16020
ctcctgacc  cgtgatctg  ctgcctcgg  ctcccaaag  cctgggatt  caggcgcga  16080
ccaccacac  cggcctaaa  aaatttttt  agacacagt  ctctgttgc  taggctaga  16140
tgcagtggt  caatcatag  tcactgcag  ctcccactc  tgggctcaa  tgatcctcc  16200
acctcagca  cctgagtag  tgggactac  ggagtgcac  accatgccc  gctaatttt  16260
acatttttt  taagccggg  gcagtggct  atgcctgta  tcccagcac  ttgggaagc  16320
gaggccagt  gatcacaag  tcaggagtt  gagaccagc  tggccaaca  ggtgaaacc  16380
cgtcactac  acaaataca  aaattaccg  ggtgttttg  cgggcgcct  taattccag  16440
tacttggag  ctgaggcag  agaatcgct  gaagctggg  ggtggtggt  gcagtgagc  16500
aagatcgcg  cactgtact  cagcctggg  gacagagtg  gactctgtc  caaaaaaaa  16560
aaaaaaaaa  agatgaggc  agaaaggat  aggattttg  atttttaag  ttactacta  16620
ttggtggcc  ggtgtggtg  ctcacacct  taatctcag  gctttggga  gccgaggca  16680
gcggatcac  tgaggtgag  agcttgaga  cagcctgac  aacatggag  aactccgtc  16740
ctactaaaa  tacaaaatt  gcctggcat  gtggctcac  cctgtaatc  tagccactt  16800
ggaggctga  gcaggagaa  tgcttgaac  tgggaggtg  aggttgcgg  gagccaaga  16860
tgtgccact  cactccagc  tgggcgaca  gagcgaaac  ctgtctcaa  aaaaaaaga  16920
acaaagaaa  agagattaa  actacttag  aacagccaa  ccttcaacc  accgcaaca  16980
ccttgtttt  cctgcaggg  cctgagaga  tgcgttcct  gactgcccc  gaagccagt  17040
ctgccgcta  cacccctgc  accccaccc  cactgccgt  gggaccaga  accccctct  17100
ctgggaggc  acctgccag  gtttattta  gcaggcgcc  tccggtatc  gtgtgcccg  17160
ccagtgacc  aacagcccc  ttttcgaag  ccccacact  tcaggggaa  cagaactgg  17220
cacagatac  ttgagcacg  tgaggtgag  gctgggcca  ccacaggga  ctaggcctg  17280
gaaggagag  gtcattgtg  aatcatcgt  tttagaaaa  aggtttttt  tctgcatag  17340
aggcagccc  gaatggtgg  ccacactat  aataatcaa  caagccaca  aggtctgta  17400
gtttttgct  cgcaccagg  gctgcctta  gcactttaa  ctttaggta  agttgtcac  17460
cccatttta  agatggggg  aaaacaggc  ggcagggtg  ctcaggcct  tcatcccag  17520
actttagga  gccgaggca  gcagatcac  tgaggatca  gagtttgat  ctagcctgg  17580
caacatggc  aaaccccgt  tctactaaa  atacaaaaa  taaggcgtg  tggtgggcg  17640
ctgtaatcc  agctactct  gaggctgag  caggagaag  gcttgaacc  ggaaggcgg  17700
ggtttcagt  agccgagat  gtgccactg  actccagcc  gggcgacag  atgagactc  17760
gtctccaaa  ataaaaaat  aaaaaaaag  aaacgaaaa  aaatgggga  agtgagtca  17820
agagaagtg  agtgacttg  ccaagtggg  agggggcag  accacgatg  tatcccagg  17880
ctttgatct  gaccttggg  ctttgagca  tctgcagtg  ggcttctgg  cgggacacg  17940
tggcagcac  tgctgctgg  ctgaggagc  gggatttta  ctggagggc  ctagggagc  18000
acaggaggt  ttagagcaa  attcttcag  tagcgccat  gcattccac  ctgggcgac  18060
gagggagac  ccatctcaa  aaataaaag  agattgcat  aaaatagtg  ttatcctga  18120
gacttaggt  tttggcatc  ccttagctt  tttattttt  tttgagaca  ggttcttac  18180
ctgtcaccc  cgctggagc  cagtggtgt  acttcggct  actgaagcc  cgacctccc  18240
ggctcaagc  atctgccca  ctcagcttc  cgagtatcc  ggatgaaaa  cgtgtgcca  18300
cacgcccgg  taatttttg  ttttcatag  gatggggtt  caccatgtt  cccagactg  18360
tcttgaact  ctgggctcc  gcagtctgc  ctcctgggc  tcccaaagt  ctgggatta  18420
aggtgtgag  caccacgcc  ggcccctct  aagtttgac  cctgaaaaa  ggacctcac  18480
ctcggccgg  cgggctcac  cctgtaatc  cagcacttt  ggaggccga  gcgggcaga  18540
catctgagg  cgggagttc  cgaccagcc  gaccaacat  gataaaccc  gtctctact  18600
aaactacaa  attagccgg  cgtggtggt  ggtgcctgt  ataccagct  ctcaggagg  18660
tgaggcagg  gaatcgctt  aacccagga  gcagaggtt  cggtgagcc  agatcacac  18720
attgcactc  agcctgggc  acaagaatg  aactccatc  caaaaaaag  agaaaaaaa  18780
aaaggacct  actctcaag  acactcatc  tggtcctag  cctgcctca  tcaaatagc  18840
aagtctgct  tttggacat  ctggcccag  tcattcatt  tcttggggg  caaggggcg  18900
cctgggcac  gcagggtgc  gagcggtgt  cctggcctc  actcactcc  tgccagggg  18960
acccccgag  tgttccgcc  acaggtgtc  ccagacatc  cccagtgtc  cgtgggggg  19020
acaatgaca  gagaatgag  acccctggc  tagagcatg  aagaaacag  gcagctggt  19080
gtagaagat  ctccccggt  gtgtgatgg  aggattagg  gagagatgg  cagcctggg  19140
tgggcccat  gcaaagagc  tttttgggg  gcataacaa  aacagaatg  agatggcgg  19200
agggtgagg  agggcagac  gcttgccgc  ggagggaat  tgtaattaa  tggcgagaa  19260
tggggttta  gcacatcac  gtgtctggg  ggctgccac  gagcccccc  accccacac  19320
cataacccc  cacccccgt  cctgacccc  cgtgtccgg  tcacggtcc  tcctctccc  19380
gggattctc  gggccacat  tggggccaa  gcggggcgg  gatctgtct  atggatcca  19440
tcgtctgag  ccaggctca  ggcctggtt  caaatgagc  ctgggcccc  cggcctcca  19500
ggcagagcc  ggcgctggc  cgtgatgga  ggggccgca  ggccattaa  cacaggccg  19560
ggaggaaac  ggtggccgc  gtgcagaag  agggacctc  ctctgctgg  cccgggtgg  19620
ggtaggact  agctgtcca  ccctggggt  gagctcccg  actgctgct  cctggccgg  19680
tgacgtggg  ccatgagag  tcactgctc  agaccttag  gtcacccca  tgctactcc  19740
aaatgcagc  tcagatact  agagagcag  tactgtgtg  caggcatgc  tgtaagtgg  19800
ggttctgag  agtgaccaa  gagagaaat  cccccactc  accttttgg  gctgataag  19860
ttaaaactt  tatttattt  tatttttgg  gacggagtt  agctcttgt  gcccaggct  19920
cagtgcagt  gcacgatct  ggctcactg  aacctctgc  tcccaggtt  aagcgattc  19980
cctgcctca  cctcccgaa  agctgggat  acaggcgtg  gccaccacg  ctggctaat  20040
gtttgtatt  ttagtagag  tggtgtttc  ccatgttgg  caggctggt  ttgaactcc  20100
gacctcagg  gatccaccc  cctcggccc  ccaaagtgc  gggattaca  gcgtgagcc  20160
ctgcacctg  ccccattct  gattgaagt  tcactctct  aatgaagct  ccttcagct  20220
ccctatttg  ctgaggcag  gctaggacc  gggtgaatg  acctgggag  gaggtcctt  20280
cttaaggca  aaaacttaa  agaggcagg  tgaggtggc  cacgcctgt  atctcagca  20340
tttgggagg  caaggaggg  agattgctt  atcccagaa  ttcaagacc  gcctgggta  20400
catggtgaa  ccccaactc  acaaaaaac  aacaaacaa  aattagcca  gtgtggtgg  20460
gtgtgcctg  tgtcccagc  actcaggag  ctgaggtgg  aggattgct  tagcccggg  20520
ggctgaggc  gcagtgagc  aaaatcaca  cattgcact  cagcgtggg  gacagagtg  20580
gaccctgtc  caaaaaaaa  aaagaaggc  gggcgcggt  gctcacgcc  gtaatccca  20640
cactttggg  ggccgagac  ggcggatca  aaggctagg  gatggagac  atcctggcg  20700
gcgcgcaca  acacacaca  acacacaca  acacgccgg  cgtggtggc  ggtgcctgt  20760
gtcccagct  ctcgggagg  tgaggcagg  gaatggcgt  accccggga  gtggagctt  20820
cagtgagcc  agatcgcac  actgcactc  agcctgggc  acagagtga  actccgtct  20880
aaaagaaaa  aaaaaaaga  agaaaaaaa  agttaaggg  atgccaaat  cctaagtca  20940
caggataaa  actgttttg  tgcaatcta  gtgtttttt  gtttgtttg  tttgttttt  21000
gagacagag  ctcgctctg  cgcccaggc  ggagtgcag  ggcatgatc  cggctcact  21060
caagctccg  ctcccgggt  cacgccact  tgctgcctc  gcctcccga  tagctggga  21120
tacaggcgc  cgccgccac  cctggctaa  tttgtttgc  tttttagta  agacggggt  21180
tcaccgtgt  agccaggat  ctctcaatc  cctgacctc  tgatccacc  ccctcggcc  21240
cccaaagtg  agggattac  ggcgtgagc  accacgacc  gcccacttt  ttttttttt  21300
ttttttttt  acggagtct  gctctgtcg  ccaggctgg  gtgcaatgg  gcaatctcg  21360
ctcactgca  cctctgtga  ccactcacc  ccccttccc  agtgctggg  ttaccggca  21420
gaaccaccg  gcccagcca  caatatttt  acaaatcaa  attaatgaa  aaaaatcca  21480
aatgaacaa  atatcaaaa  gttaaataa  aatcttgca  aactcactc  gactgcctc  21540
taggcccag  tcatagagg  ctcaaccca  attccgcgt  caggtcatg  ggtcagcgt  21600
ttccctgct  catgggaca  agcactgtc  gacgtgtaa  gcggtttgt  tgtttactt  21660
cttgaatgt  ggccccggg  ggcaggggg  ttggtgagt  ctggtcact  ttgtatcct  21720
aatacctag  acagggcct  gctcagtat  aatgcccaa  agttactga  tgagtgaat  21780
aataaatga  tgggttaag  tgacacacc  ggttgttgc  gaattaaat  agataagac  21840
ctggaagta  ttagcacac  gcacccagt  ggctcctga  atccttaat  tacacctta  21900
ggcctgagt  caatgttct  attggccag  cctgggtca  atgacatcc  tgagacaaa  21960
tttatggct  gagtagaat  ctctgattg  ccagccttg  gtcacatga  ttttctttt  22020
tctttttct  ttttttttt  tttttttga  acagagtct  gctctctcg  ccaggcagg  22080
gtgcagtgg  cggatctct  ctcactgca  actccgctt  ccggtttca  gccgttctc  22140
tgcctcagc  tcctgagta  ctgggacta  aggcgcccg  caccacgcc  ggctaattt  22200
ttgtatttt  agtagggac  gggtttcac  gtgttagcc  ggatggtct  gatctcctg  22260
cctcgtgat  cacccgcct  agcctccca  agtgctggg  ttacaggtg  gggccagca  22320
gcctggcct  gacaattac  tcctctgag  ggccttctc  aaccagtca  atggaaaaa  22380
caaaaaata  tgttattat  tcactctat  ttattgtta  ctattttta  ttatttatg  22440
ttatttaac  ttttgatat  tatttattt  tgagacgga  tctcgctct  tcacccagg  22500
tggagtgca  tggcatgat  tcggctcac  gcaacctcc  actcccggg  tcaagtgat  22560
ctcctgcct  agcctcctt  gtagctgag  ttacaggca  gtgccacca  gcccggcta  22620
ttttgtagt  ttagtagag  cggggtttc  ccatgttag  caggctggt  tcgaactcc  22680
gacctcagg  gatcccccc  gcctcagcc  cccaaagtg  tgggattac  ggcatgaga  22740
accgcgcct  gcccaattt  tgtattttt  gtagagatg  gatttcacc  tgttggcca  22800
gctggtctc  aactcctga  ctcaggtga  ctgcctgcc  cagcttccc  aagtgctgg  22860
attacaggt  tgagccact  caccctggc  gggctgatt  ttttttttt  ccaagagtc  22920
gggtctcac  atgttgccc  ggcttgtct  gaactcttg  ggtcaagca  tcctcccac  22980
ttggccttc  agagtgctg  gattacagg  atgaaccat  gtgcctggc  taattttat  23040
ttatttttt  agtcagtgt  ttgggctgt  atgcaggct  gagaacagt  gtgccatca  23100
agctgattg  agcctcgaa  tcctggcct  aagtgaccc  cccacctca  cccctcaaa  23160
tgctgggac  agatgcgtg  gccaccagg  aggccagct  tcatcttta  tatctgtca  23220
cctgaaaga  ccatgagag  aaggagcgg  ctgccttct  cactgctgt  tcccagggc  23280
cagcttggg  tctggcaaa  aatttctac  cagtgcaaa  atcaggtct  agtgaaatg  23340
aagaatgag  tagtattta  ttatctgga  atggagtct  gctctgtcc  ccaggctgg  23400
gtgcagtgg  atgatctgg  tctcggctc  ctgcaacct  tgcctctcc  cccgagttc  23460
agcaattct  ctgcctcag  ctcccaaat  gctgggatt  aagatgtgt  ccaccatgc  23520
tggctaatt  ttgtgtttt  ttgtttgtt  gtttttgga  acggagtct  gctctgttg  23580
cagactgga  tgcagtggc  cgatcttgg  tcactgcaa  ctccacctt  tgggttcaa  23640
tgattcccc  gcctcagcc  ccccagcag  tgggattac  ggagtgtgc  gccatgcct  23700
gctaatttt  tgtatgtta  tagatatgg  gtttcacca  gttggccag  agggtctcg  23760
tttcctgac  ttgtgatcc  cccgcctca  cctcccaaa  tgctgggat  acaggcgtg  23820
gccaccgtg  cctgcctta  ttttttatt  ttagtagag  cagggtttt  ccatgttga  23880
caggctgct  tcaaactct  gacctcagg  gatccacct  ccttggcct  ccaaagtac  23940
gggattaca  gcgtgagcc  ctgtgcctg  ctgacagta  ttatttatt  tccccatat  24000
ccagatgag  aaactgtgg  tcacaaagg  gcgatcatg  attttgtct  ccttcctct  24060
cacccccag  gctctgtca  acaacatgg  tttattgaa  acttgcacg  ctggtcttc  24120
tctagatat  agggataca  tgacccaca  agctccaac  ttacagcct  gcaggggag  24180
cagacatta  taaaatcac  atacaaaca  atgtggtta  aatccctca  caatcccat  24240
ggctccagc  ttaccaata  acccagaat  caatcaatt  ccactaact  tagggttac  24300
atcctggct  atatcccca  caacttgtt  agtgcagca  tctctcatc  cacgtcgta  24360
tttttgagt  gatgtgaca  cggaataac  ataacaaaa  aaaaaaaac  gaatggctt  24420
agtccatgg  actgaacat  catgacatt  gggctgact  caggcatgg  ttgatccag  24480
ggctccaac  ttatcggga  cctgtgtca  tgtgcatag  tgggacagc  gtctcccat  24540
gcagcaaac  aacaccgtt  cccagcagc  gtaagcttt  atcctccca  ctcagcaac  24600
ccagccaat  ccttctgct  aattacagc  tgtctcagg  ctcattctc  ttggccagg  24660
ttaggtgac  tgacatccc  gatataatc  ctatgttct  gctggaata  tctgattgg  24720
caatcttgg  tcacatgac  tttccattt  aatcttttt  ttttttttt  tttggaggg  24780
ggagatgga  tctcattat  ttgctcagg  tggagtgca  tggcatgat  ctggcttac  24840
gcaacctcc  cctcccggg  tcaagtgat  ctccttcct  agcatccaa  tagctggga  24900
tacaggcgc  tgccaccac  cctgtctaa  ttttatatt  ttagtagag  cagggtttc  24960
gcatgttgg  caggatggt  tcaatctcc  gacctcgtg  tccacccgc  tcggccgca  25020
aaagtgctg  gattacagg  atgagccac  gcgcctggc  taatttttg  atttttcta  25080
agatggtat  tcaccatgt  ggccaggct  gtctcgaac  cctgacctc  tgatctgcc  25140
gcctcagtt  cccgaagtg  agggattac  ggcatgaga  accacgcct  gcctgttgt  25200
gttttgaga  gggggtctt  ttatgttgc  caggctggt  ttgaactcc  agactcaag  25260
cacccgccc  cccttggct  cccaaagtg  tgtgattac  ggcatgagc  actgcactg  25320
gccaaatgt  ttttgtttt  gtgcttttc  ccgtcccca  cgcccccag  tgccggcct  25380
gggagcctg  tgttggcag  actgtgagt  actgttggg  tgtttaagg  cctttaaaa  25440
gtgttccca  catttcccg  gggctgtgc  ctaattagg  gattagtag  ctgactcct  25500
cagatgtct  cctggggat  ccgggggac  gtggggagc  gggaagtgt  gctgcctac  25560
tggcctgcc  tccagaggc  ccattgcct  cccatagac  cccaagggg  aagtgccag  25620
ctcagcttt  cgacaggtg  gctctgtgt  tctggacaa  tggctgtcc  tctctggtc  25680
catctatct  ctttcccat  tatctagtg  gctgtgggc  tatactatg  tcctgtagg  25740
gccagagcc  ctattcttg  tctgttact  agatacctc  aacctctcc  cccagcaaa  25800
taatcatcc  ctttatcat  aatggctga  gtttaccaa  ttttctcag  gccccagca  25860
tgatccagg  cttcaaggt  ggcgcagtt  ttactactt  ttttttttt  tttttttta  25920
atttcagag  cagggtctg  ctctgtccc  caggctgga  tgcagtgca  gatcatagt  25980
cactgcgcc  ccacctccc  ggctcaaat  atcctccca  ctcagcttc  tgagtagct  26040
ggactacag  tgcacacca  cacacctgg  taattttaa  tttttttgt  gagaagggg  26100
ctccctatg  tacccagac  ggttttgaa  tactgggct  aatcgatcc  cctgcctcg  26160
cctcccaaa  tgttgggat  acatttgtg  gccactgta  ctggccaaa  tttgtgggg  26220
tttttgttg  ttgtttttt  gagacagag  cttgctctg  tgcccaggc  ggagtgcag  26280
ggcatgatc  tggctcact  caacgtcca  ctcccaggc  caagcaatt  tcctgcttc  26340
gcctcccga  tagctggca  tccagctgc  catgaccac  cccagctga  ttttgtatt  26400
ttagtagag  tggggtttc  ccagtttgg  caggctggt  ttgaactcc  gacctcaaa  26460
gatccgccc  cctcagcct  ccaaagacc  ggggttaca  gcatgagcc  caaaaattg  26520
gtccaatct  tgctcacac  agagaccag  ataaactcc  aatgggcca  acagcgtaa  26580
ccagggggc  ccagctcct  ggactcacc  cctctctcc  tccccactg  gggtgtgga  26640
ttcaatgtg  acagcctcc  agacccagt  gggcagatg  tcatgggac  cagagtctc  26700
tgggggggt  cgtggaatc  cataaccca  ggggtctca  ccagggtga  tctgctccc  26760
gggggcact  ggtgatgtc  ggggacatt  gtggttgtc  caatggtgg  tactcttgg  26820
atggagtgg  tggaggcca  ggatgctgc  cagcaccct  cagtgccca  gacggcttc  26880
tcccagaga  ctatctggc  ccaaatgtc  acagcggcc  ggggagaga  ctcattcca  26940
agctcgata  ccaccaacc  tgcatggtt  cttaggttt  cactgagat  gatggaaac  27000
ggccaggct  taattaacc  cagcgcttt  ggaggtcga  gcgggagga  tgattgaac  27060
caggaggtc  aggctgctg  gagctatga  cgcggccct  cattccagc  taggtagca  27120
tgacaagct  tagatagat  gatagatag  tagatagat  gataaaaat  agatgaaag  27180
tgcatttcc  cagttgccc  ggccacggt  caggggctc  gcagcccac  agtgaccac  27240
acgtgggac  ccacggagc  agaatgtag  cgatgtggc  gaaagtcct  gcgggccgc  27300
cagcgcgga  acctccccg  gtgcaaacg  tccccgccc  ccacccacg  ggcgcccgt  27360
ccgccggcc  ctgttccac  gatgcccac  cgggggcag  gtgtcatca  gatctcgcg  27420
accttggct  aggtcgcct  cacctgccc  ctccccagg  gggtgagcc  ggccgctgg  27480
ggtttggag  cagcagccc  tcggcttac  aatcctttg  gagcacctg  tgtgtgcca  27540
gctgtgtgc  gggacagct  agtaaatca  agagtctta  ccatgcttt  tcaccgtgg  27600
ctttacggg  gggatggtt  tctggggtg  ggctgtcct  ggcactgca  ggtgctgag  27660
agcgtccct  gcctccact  actccatgc  aggcgcacg  cccagtcgt  acaaccaca  27720
atgtcccca  acatcaccc  gtgccccct  ggagcagaa  catcctcca  gttagaatc  27780
ctgggttag  ggattccgc  gacccccaa  agactctgg  tcccatgat  ctctgccct  27840
ctgaggtcc  aggtggcta  acacattga  atccacacc  tgagtgggg  gggagagag  27900
aggtgaatc  caagggtcc  catggtttg  accatctgc  ccatcggga  cttattctg  27960
tttctggtg  gagcaggga  cagactcaa  tttcccccc  aataattaa  taagagatc  28020
ccattctag  cactgtgga  attcaaggc  ggattgtcc  ctaggatga  gccgccttg  28080
gcactgcag  gtcctgagc  gagtccctg  catccaccc  ctccatgcc  gcagcacct  28140
ctccaagtc  cgacaacca  aaatgtccc  agacactgc  gtcaatctc  tgatcaagg  28200
gtgcaaaat  accgccacc  gagaattcc  ttctttttt  tttaatttt  tttgagaca  28260
agtctcgct  tgtcaacca  gctggagtg  agtggcacg  tctcggttc  ctgcaagct  28320
tgcctccca  gttcatgcc  ttctcctgc  tcagcctcc  gagtagctg  gactacagg  28380
gcccaccac  acatccagc  aattttttg  atttttagt  gagacgggg  ttcaccatg  28440
tagccagga  ggtctcgat  tcctgacct  gtggtccgc  tgcctcagc  tcccaaagt  28500
ctgggatta  aggcgtgag  caccgcagc  ggccaaaaa  tcctttcta  tgaatcaac  28560
catcacaca  ataaatatt  atttgttta  tttattttt  tttagtttt  ttgagatgg  28620
gtcttgctg  tgtcgccca  gctagaatg  aatggcacg  tctcggctc  ctgcaacct  28680
cacctcccg  gttcaagtt  ttctcctgc  tcagcctcc  gggtagctg  gattacagg  28740
acctaccac  gtaccctgc  aatttttgt  tttttagta  agacgaggt  ttgccacat  28800
ggccaggct  gtcttgaac  cctgacctc  tgatccacc  acctcagcc  cccaaagtg  28860
tgtgattac  ggtgtaagc  accgtgccc  gcccacaca  aaatatatt  aaattatga  28920
ataagcagt  atggccagg  gcagtgtct  acgcctgta  tcccagcac  ttgggaggc  28980
gagatgggc  gatcacgag  tcaggagat  aagaccatc  tggctaaca  agtgaaacc  29040
cgtctctac  aaaaataca  aaaaattag  cgggtgtgg  ggcgggcgc  tgtagtccc  29100
gctactcgg  aggctgagg  aggagaatg  cgcgaaccc  ggaggtgga  tttgcagtg  29160
gctgagatc  cgccactgc  ctccagcct  ggtgactaa  tgagactcc  tttcaaaag  29220
aagaaagaa  gaaagaaag  gagagagag  gagagagag  gagagagaa  gaaaggaag  29280
aaggaagga  ggaaggaag  aagaaagga  ggaagaaag  aagaaagaa  ggaagaaag  29340
aagaaagaa  cagttatat  aggtgaggg  gctgtaaac  tttcttgac  atcacatct  29400
cacccaggt  aaagtgatt  tcctgcctc  gcctcctga  tagctggga  tccaagtgc  29460
cgccaccat  cctggctaa  ttttgtatt  tttagtaga  atggggttt  gccatattg  29520
ccagtctgg  ctcgaactc  tggcctcag  tgatccgcc  gcctcggcc  cccaaacac  29580
catatacac  catgtactc  ggacagagg  ttaagtacc  gcataaccc  aataaaaat  29640
gcacaagat  actcttcgc  ctgcaaagc  ccacgcact  tgatgtttc  tattctact  29700
catttaaaa  atatatatg  gtcatgatc  actgaattg  tttctccac  cacagactg  29760
aaaaaataa  aattaaaat  gcgactggg  atcacgcac  ccagaaaca  ccccaggcc  29820
ttccactgt  gaaaaaaat  aatgagcca  gcaccaagg  tcacacctg  aatcccagc  29880
ctttgggag  cctaggtgg  cagatgacc  gaggtcagg  gttcaagac  agcctggcc  29940
acatggtga  acaccatct  tattaaaaa  gcaaaaatt  gccgggtgt  gtggtggga  30000
cctgtaatc  cagctactc  ggaggctga  gcaggagaa  cgcttgaac  tggaaggcg  30060
aggttgcag  gagccgata  cgtgccatt  cattccagc  tgggtgaca  gaacaaaac  30120
ccatctcaa  aaaataaat  aaaaaaaaa  tagtggtag  ccggcacgg  ggctcacac  30180
tgtaatctc  gcactttgg  aggctgagg  gggaggata  cttgagccc  ggaggttga  30240
gctgaagtg  gccatgatt  caccactgc  ctccagcct  ggtgacaga  tgagactct  30300
actcaaaag  aaataaata  atataaatg  ctccttctc  ctttattta  ctgtctatt  30360
tccaaatag  ttcatggat  ctctctctc  ctctttttt  tttttttag  tggagtttc  30420
ctgtcgccc  ggctggagt  cagtggcat  atctcagct  actgcaacc  ccgcctcct  30480
ggttcaagc  attcttgtg  ctcagcctc  ctagtacct  gaattgcag  catgcatca  30540
cacacccag  tagtttttg  atttttagt  gagacgaga  tttgccatg  tggccaggc  30600
ggtctcgaa  tcctgatct  aggttatct  cttgcctct  cctcccaaa  tgctgggat  30660
actgcagcc  cccgagtag  tgggactac  ggtgtatgc  atcatgcct  gcagatttt  30720
ttttatttt  ttgtggaga  aggttctcc  tgacaagcc  aggctggtc  tgaacgctt  30780
gcctcaagt  atgtgcctg  cttggcctc  caaggtttt  agactacag  catgagaca  30840
cttgccagg  ccagaagga  gggtttaga  ggagtaaca  ggatagaca  agttacatt  30900
tgtagggac  gagctcaca  tgtgggtag  cagttccag  cagaaggca  aggctgtgc  30960
aaggccctg  ggtaggact  tgcctgact  gttagagga  cactaagga  acctgtgtg  31020
ctggaggaa  gggagacag  gaggagggg  ggacgggga  gggctggtg  aggcccttg  31080
gggccatgg  gcggacttg  gcttttcct  aaggaaggt  ggagccatg  agggctgtg  31140
gccgaggag  gacaggccc  gactcagat  tgaattcag  tatgaaggc  gagtgtggt  31200
gctcatgcc  gtaatccca  cactttggt  ggctgagtg  ggaggatca  ttgaggtca  31260
gagttcgag  ccagcctgg  caacatggt  aaaccccgg  tctactaag  tatacaaaa  31320
ttagccaga  gtggtggca  gcacctgca  tcccagcta  tcaggaggc  gaggcacaa  31380
aatcgcttg  acccaggag  ggaaggttg  agcgagccg  gattgtgcc  ctgtactcc  31440
gacagggca  cagaataat  ctccatcag  aaaataaat  cataaataa  ataacaata  31500
ttcagtgtg  ctttaacat  aagaggctt  tccactaaa  ccatgtctg  agaaaccgg  31560
cacgagctg  ccctggctg  gcgtgggga  gtctgtgga  ggtcagacc  ccctgggct  31620
ggaatgggc  tgtttcaaa  gcagcttcc  ggggctggc  ctccgcaca  tctaattca  31680
caaaggcgg  gcagagtct  agctgtgac  ccgtgtccc  ggtgtttcc  gaatcat  31737



<210> 2935
<211> 197
<212> PRT
<213> Homo sapiens
<308> AAC72103
<400> 2935

Met Met Phe Pro Gln Ser Arg His Ser Gly Ser Ser His Leu Pro Gln 
  1               5                  10                  15
Gln Leu Lys Phe Thr Thr Ser Asp Ser Cys Asp Arg Ile Lys Asp Glu 
             20                  25                  30
Phe Gln Leu Leu Gln Ala Gln Tyr His Ser Leu Lys Leu Glu Cys Asp 
         35                  40                  45
Lys Leu Ala Ser Glu Lys Ser Glu Met Gln Arg His Tyr Val Met Tyr 
     50                  55                  60
Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Ala Glu 
 65                  70                  75                  80
Ile Val Lys Arg Leu Asn Gly Ile Cys Ala Gln Val Leu Pro Tyr Leu 
                 85                  90                  95
Ser Gln Glu His Gln Gln Gln Val Leu Gly Ala Ile Glu Arg Ala Lys 
             100                105                110
Gln Val Thr Ala Pro Glu Leu Asn Ser Ile Ile Arg Gln Gln Leu Gln 
         115                120                125
Ala His Gln Leu Ser Gln Leu Gln Ala Leu Ala Leu Pro Leu Thr Pro 
     130                135                140
Leu Pro Val Gly Leu Gln Pro Pro Ser Leu Pro Ala Val Ser Ala Gly 
 145                150                155                160
Thr Gly Leu Leu Ser Leu Ser Ala Leu Gly Ser Gln Ala His Leu Ser 
                 165                170                175
Lys Glu Asp Lys Asn Gly His Asp Gly Asp Thr His Gln Glu Asp Asp 
             180                185                190
Gly Glu Lys Ser Asp 
         195



<210> 2936
<211> 1210
<212> DNA
<213> Rattus norvegicus
<308> L15011
<400> 2936

gaacagccg  ggcggcccg  ctggcgcgc  gctctccat  ctcgctcgg  ctccaccgc  60
ccaggggcg  atggggtgg  ctgagccgg  gctgccaca  cctccgcca  taccgccgc  120
acccgggga  gaccagagc  aagcagcga  gagtcccaa  aaagagaaa  agagagggg  180
tgcagggcg  ccggtcccc  tctaggacc  aggagcgcg  cgatgtgag  tatgagtgc  240
ccgtggaca  tgtcaccgg  gccgctgcc  ccatcgacg  ggcctccgg  gggcgcggg  300
ctggacgtc  agcaacgca  ggtgttcgc  ttcgtgctc  gcctgctcg  ggtgttggt  360
ctgttgatg  tgcgctgtg  acgcatact  ctagacccc  acagccgca  gcccgcctc  420
tcctggacc  accacaagg  ggcgcttga  cgtgggcag  tcgactatg  gttggtgtg  480
tgaggaacc  gtcccgggc  ggtccttag  gagatccca  aagggtcgg  cccgtggag  540
gtgccccca  cctggactg  gctcagggt  atgcctaga  gccctagct  agagttgag  600
gcgttcgga  aagtccagc  cttacccac  ttaaccacc  atcttccat  ctggccagg  660
cagaacccc  cacctggtg  ctttatctg  cctgtcccc  tctctacac  ctcatcctc  720
atgctgatc  ctcaacact  aatccctag  gagcgaagc  cccggcacc  acctcagcc  780
tccccaaca  ccaggcatg  tacatcctt  cctgggaat  cggactcct  ttatctctt  840
ttcctttcc  cctgttatg  tcatcagca  tgtcagtgc  cttcttgag  tctggccct  900
gcaggcagg  tctcttcga  tcacattgg  cactgccta  ctataatgc  cggtacagc  960
tgccccaga  acagacccc  aaactccac  atggctgct  cttgtgttg  taatgtctg  1020
cacttatgt  caggagtac  aggaggctc  ttcccttcc  agacccggc  ccagcacag  1080
ttagagtgc  tttcctttc  tttgcccca  ctctcctat  tccccccat  tccccatgc  1140
cttccctgc  tatcacacc  ccctggctc  gaacggtgg  gatgataat  aaaactatt  1200
ttgagtgctt  1210



<210> 2937
<211> 82
<212> PRT
<213> Rattus norvegicus
<308> P41237
<400> 2937

Met Ser Ala Pro Trp Thr Leu Ser Pro Glu Pro Leu Pro Pro Ser Thr 
  1               5                  10                  15
Gly Pro Pro Val Gly Ala Gly Leu Asp Val Glu Gln Arg Thr Val Phe 
             20                  25                  30
Ala Phe Val Leu Cys Leu Leu Val Val Leu Val Leu Leu Met Val Arg 
         35                  40                  45
Cys Val Arg Ile Leu Leu Asp Pro Tyr Ser Arg Met Pro Ala Ser Ser 
     50                  55                  60
Trp Thr Asp His Lys Glu Ala Leu Glu Arg Gly Gln Phe Asp Tyr Ala 
 65                  70                  75                  80
Leu Val 
                 85



<210> 2938
<211> 990
<212> DNA
<213> Homo sapiens
<308> BC024148
<400> 2938

ggcacgagg  gtgttcgcc  tcgtgctct  cctgctcgt  gtgctggtg  tgttgatgg  60
gcgctgcgt  cgcatcctg  tcgacccct  cagccgcat  cccgcctcg  cctggaccg  120
ccacaagga  gcgctcgag  gcgggcagt  cgactacgc  ttggtgtga  gggcgcggc  180
ccccctagc  ggccctgcg  cggggtctc  gagggccgg  ccggcgggg  gcgccgcgg  240
gccaggact  cgctcagga  cccgccccg  agcccccag  ccgggggag  gggggaggg  300
gttgggaga  gcccagccc  tccccctcg  gacccctcc  atgtccctt  ctggcctgg  360
cggagcccc  cctcgtgcc  ttatccgcc  tgtcccttc  tctctgcgc  tctcacccg  420
ccggctggc  cccaccccc  actctgaat  ccgggcggg  ggaggaccc  cgcaccgcc  480
cctccccag  gtgtaagtg  ctctgctat  gtgcgtccc  ggaagtggg  acccccttg  540
ccctcctcc  tcccctgtt  tctggccgt  gtcaacccc  ccttgactg  gtgttgagc  600
cgtccttgg  ctctggtcc  tgcggggca  gctctcccg  gcccacggg  cggacgctg  660
ataccaatt  gccctgcac  gcctgtccc  gagacggag  ccgaaggcc  gccatggcg  720
ctgtgtcga  gatgcgtgg  gcctgccgt  gcgggacag  gtgggcagg  tcatttctg  780
ccccaaccc  ggccccagg  caggtcagc  cgccctgcc  cggtgccca  cgctgcccc  840
catccgccc  cctgccact  gcccctgac  cccctgccg  gcctcccgc  gccctccca  900
gccgttcca  tcctccctg  ctttgagcc  aacatgata  taaaagcta  tattgagcg  960
ttaaaaaaa  aaaaaaaaa  aaaaaaaaaa  990



<210> 2939
<211> 2299
<212> DNA
<213> Rattus norvegicus
<308> L15354
<400> 2939

ccactgcag  ttttctctg  tgcttaagg  tttcggtta  ttctctttc  ctaagcgag  60
gttctttgt  ggtgacccg  gttgctagt  cagaaggaa  agactgagt  agcgaggcg  120
catgacaac  ctggatgac  agttgctgg  ggagaaatt  cagtactac  acagcacca  180
tgaggatga  gacagtgac  atgaagaca  agacagagg  aggggagcc  cagccagta  240
ttccacgcc  gcggaggct  agctggcag  cgaaggcat  tcagtcaat  caggtccaa  300
aggggtgat  aatgactgg  gccgcttca  gcagttgga  acagaacag  gggaggagc  360
gtgccggga  atggagcgg  tgatcaaaa  gctgtctat  agctgcagg  cccatctgg  420
tgaagagga  gagcagcag  aacagaagg  cctccagga  aaaatcagt  ggaagatga  480
tctgaagga  tgtggtatg  tggacaaga  tttggatga  gaagagttt  tgcagcagt  540
tcggaagca  aggatggac  agatgcggc  gcagcttca  aaagggccc  aattcaagc  600
agtgcttga  atccccagt  gagaaggat  tttagatat  attgataaa  aacagaaaa  660
cacccttat  atggttcat  tttatgaag  tggtgtccc  gggactgaa  ccatgaatg  720
ctgcatgat  tgccttgcc  cagagtacc  cactgtcaa  ttctgccga  tgaggagct  780
ggttattgg  gccagcagt  gttttaccc  gaatgccct  cctgctctg  tcatctaca  840
ggcgggtga  ttgattggc  attttgttc  tgtcactga  cagctgggc  aagatttct  900
tgctgtaga  cttgaagct  tcctgcagg  atttggatt  ctcccagaa  aggaagtct  960
ggtgctgac  tctgtgcga  actctgcca  ctgtcacag  gaagacagc  atctagaaa  1020
agattgaac  gataatcca  ttctgtagc  gtctcattg  ttgggctag  ggacacatg  1080
ctgtattta  ttctgtcct  cctgtcttc  ggctttaca  ctgctcttt  tagtctggt  1140
tagtatgtg  aaagtcaag  aactcagat  aaatcagaa  cctgactca  tttgtggct  1200
gcagtaaag  gatttctaa  tatatagac  ggaagctgg  ttcttgagc  gtttacatc  1260
ctagcgtga  atctctgaa  ttgtttcca  tcaatattg  catggcacc  ttgaaggca  1320
tgtcttgaa  attgtcttc  gatgacctc  gaattccac  aggtctgag  gtagaattc  1380
ctagtgagt  tgtttctgt  cagtgtaaa  agtgcattt  cataatcac  tgattgcaa  1440
tcatgttta  ttgcaatca  actgtactt  ttttctcca  atccttttc  accagggtc  1500
atacaaggt  gggaatata  ctcagtggt  aactcttaa  ctagcatac  cgtagctcc  1560
aggtatctg  ttcccaccc  gcactgtca  aactaaagg  tccagatgg  gcctgatgc  1620
gtagttagc  gtggtctct  ctgagggag  cactggtcc  gtccagcat  atgaagtat  1680
aacaggaag  gatgttttc  tgctgactg  tgtcatgat  ttgggaagc  ggcatccta  1740
tgactgaca  tggtgtgta  agagcttga  aacctcagt  ggaggacct  tctgtatcc  1800
gctcatcag  atcttttcc  ctgttattt  gcaaggtaa  gctttgttt  accttttta  1860
ctttttaaa  agctttttt  gcctattag  aaaaaattc  tatttacta  aggaaaatt  1920
gccaaaata  agatgcaaa  atggtttaa  aatataatt  tgccacctg  atactgtat  1980
ttttggtac  attcatata  agggttttt  ttttaatgt  ttctagggt  tttttttta  2040
ggattcata  gctttggtt  gtctttaaa  gacattggg  tcattctga  catactgtc  2100
gatagtgtg  tcagttact  acagaagtt  ttcatgcta  taaatactc  tctgtaata  2160
tttaataac  gttgatatt  cattgattt  ctgaaatct  gtgtttggg  tttagaaag  2220
tagcaaact  ttttattat  aactttcta  tatgaaaca  gtttatcat  gaacataca  2280
taaaaatta  gttaaaaag  2299



<210> 2940
<211> 301
<212> PRT
<213> Rattus norvegicus
<308> Q63737
<400> 2940

Met Thr Thr Leu Asp Asp Lys Leu Leu Gly Glu Lys Leu Gln Tyr Tyr 
  1               5                  10                  15
Tyr Ser Thr Ser Glu Asp Glu Asp Ser Asp His Glu Asp Lys Asp Arg 
             20                  25                  30
Gly Arg Gly Ala Pro Ala Ser Ser Ser Thr Pro Ala Glu Ala Glu Leu 
         35                  40                  45
Ala Gly Glu Gly Ile Ser Val Asn Thr Gly Pro Lys Gly Val Ile Asn 
     50                  55                  60
Asp Trp Arg Arg Phe Lys Gln Leu Glu Thr Glu Gln Arg Glu Glu Gln 
 65                  70                  75                  80
Cys Arg Glu Met Glu Arg Leu Ile Lys Lys Leu Ser Met Ser Cys Arg 
                 85                  90                  95
Ser His Leu Asp Glu Glu Glu Glu Gln Gln Lys Gln Lys Asp Leu Gln 
             100                105                110
Glu Lys Ile Ser Gly Lys Met Thr Leu Lys Glu Cys Gly Met Met Asp 
         115                120                125
Lys Asn Leu Asp Asp Glu Glu Phe Leu Gln Gln Tyr Arg Lys Gln Arg 
     130                135                140
Met Asp Glu Met Arg Gln Gln Leu His Lys Gly Pro Gln Phe Lys Gln 
 145                150                155                160
Val Leu Glu Ile Pro Ser Gly Glu Gly Phe Leu Asp Met Ile Asp Lys 
                 165                170                175
Glu Gln Lys Ser Thr Leu Ile Met Val His Ile Tyr Glu Asp Gly Val 
             180                185                190
Pro Gly Thr Glu Ala Met Asn Gly Cys Met Ile Cys Leu Ala Ala Glu 
         195                200                205
Tyr Pro Thr Val Lys Phe Cys Arg Val Arg Ser Ser Val Ile Gly Ala 
     210                215                220
Ser Ser Arg Phe Thr Arg Asn Ala Leu Pro Ala Leu Leu Ile Tyr Lys 
 225                230                235                240
Ala Gly Glu Leu Ile Gly Asn Phe Val Arg Val Thr Asp Gln Leu Gly 
                 245                250                255
Glu Asp Phe Phe Ala Val Asp Leu Glu Ala Phe Leu Gln Glu Phe Gly 
             260                265                270
Leu Leu Pro Glu Lys Glu Val Leu Val Leu Thr Ser Val Arg Asn Ser 
         275                280                285
Ala Thr Cys His Ser Glu Asp Ser Asp Leu Glu Ile Asp 
     290                295                300



<210> 2941
<211> 1192
<212> DNA
<213> Homo sapiens
<308> AL117602
<400> 2941

gggcttttc  ctttagcgc  cagggcgct  acccactgc  cttcctctt  agaaagtgc  60
ccattcctt  cggcgcccg  agctgctgg  ccaaaggga  ccggagcga  ctagggcag  120
caccatgac  acccttgat  ataagttgc  gggggagaa  ctgcagtac  actatagca  180
cagtgagga  gaggacagt  accacgagg  caaggaccg  ggcagatgt  ccccagcca  240
cagttctgt  cctgcagag  ctgagctgg  gggcgaagg  atctcagtt  acacaggcc  300
aaaaggtgt  atcaatgac  ggcgccgct  caagcagtt  gagacagag  agagggagg  360
gcagtgccg  gagatggaa  ggctgatca  gaagctgtc  atgacttgc  ggtcccatc  420
ggatgaaga  gaggagcaa  agaaacaga  agacctcca  gagaagatc  gtgggaaga  480
gactctgaa  gagtttgcc  taatgaatg  ggaccaaga  gatgaagag  ttctgcagc  540
gtaccggaa  cagcgaatg  aagagatgc  gcagcagct  cacaagggg  cccaattca  600
gcaggtttt  gagatctcc  gtggagaag  gtttttaga  atgattgat  aagaacaga  660
aagcattgt  atcatggtt  atatttatg  ggatggcat  ccagggacc  aagccatga  720
tggttgcat  atctgcctt  ccgcagagt  cccagctgt  aagttctgc  aggtggaga  780
ctcagttat  ggcgccagc  gtcagttca  caggaatgc  cttcctgcc  tgctgatct  840
taagggggg  gaattgatc  gcaattttg  tcgtgttac  gaccagctg  gggatgatt  900
ctttgctgt  gaccttgaa  cttttctcc  ggaatttgg  ttactccca  aaaaggaag  960
cttggtgct  acatctgtg  gtaactctg  cacgtgtca  agtgaggat  gcgacctgg  1020
aatagattg  actgatagt  tagttgcat  gatttctca  tgtttgggt  ggaatacac  1080
tcattgttt  tttttgttc  tttgtcttc  ggcttttca  ctgttcttt  tagtccctt  1140
tattatgca  aaaataaag  aattcttag  ttaaaaaaa  aaaaaaaaa  aa  1192



<210> 2942
<211> 301
<212> PRT
<213> Homo sapiens
<308> Q13371
<400> 2942

Met Thr Thr Leu Asp Asp Lys Leu Leu Gly Glu Lys Leu Gln Tyr Tyr 
  1               5                  10                  15
Tyr Ser Ser Ser Glu Asp Glu Asp Ser Asp His Glu Asp Lys Asp Arg 
             20                  25                  30
Gly Arg Cys Ala Pro Ala Ser Ser Ser Val Pro Ala Glu Ala Glu Leu 
         35                  40                  45
Ala Gly Glu Gly Ile Ser Val Asn Thr Gly Pro Lys Gly Val Ile Asn 
     50                  55                  60
Asp Trp Arg Arg Phe Lys Gln Leu Glu Thr Glu Gln Arg Glu Glu Gln 
 65                  70                  75                  80
Cys Arg Glu Met Glu Arg Leu Ile Lys Lys Leu Ser Met Thr Cys Arg 
                 85                  90                  95
Ser His Leu Asp Glu Glu Glu Glu Gln Gln Lys Gln Lys Asp Leu Gln 
             100                105                110
Glu Lys Ile Ser Gly Lys Met Thr Leu Lys Glu Phe Ala Ile Met Asn 
         115                120                125
Glu Asp Gln Asp Asp Glu Glu Phe Leu Gln Gln Tyr Arg Lys Gln Arg 
     130                135                140
Met Glu Glu Met Arg Gln Glu Leu His Lys Gly Pro Gln Phe Lys Gln 
 145                150                155                160
Val Phe Glu Ile Ser Ser Gly Glu Gly Phe Leu Asp Met Ile Asp Lys 
                 165                170                175
Glu Gln Lys Ser Ile Val Ile Met Val His Ile Tyr Glu Asp Gly Ile 
             180                185                190
Pro Gly Thr Glu Ala Met Asn Gly Cys Met Ile Cys Leu Ala Ala Glu 
         195                200                205
Tyr Pro Ala Val Lys Phe Cys Lys Val Lys Ser Ser Val Ile Gly Ala 
     210                215                220
Ser Ser Gln Phe Thr Arg Asn Ala Leu Pro Ala Leu Leu Ile Tyr Lys 
 225                230                235                240
Gly Gly Glu Leu Ile Gly Asn Phe Val Arg Val Thr Asp Gln Leu Gly 
                 245                250                255
Asp Asp Phe Phe Ala Val Asp Leu Glu Ala Phe Leu Gln Glu Phe Gly 
             260                265                270
Leu Leu Pro Glu Lys Glu Val Leu Val Leu Thr Ser Val Arg Asn Ser 
         275                280                285
Ala Thr Cys His Ser Glu Asp Ser Asp Leu Glu Ile Asp 
     290                295                300



<210> 2943
<211> 1964
<212> DNA
<213> Rattus norvegicus
<308> L15619
<400> 2943

ggctgccgc  gcccggtcg  ctttctgcg  tgtagcggt  tctgccgtt  cttggaagc  60
cagctcccc  tccccgccc  agtcccagt  cccgtccgg  cgcggacat  aagatgagt  120
gctctgagg  ggtgtcctg  atttcctgg  tctgtgggc  ccgtggtaa  gaattcttc  180
gtgaggtgg  tgaagacta  atccaggac  aatttaatc  tactggact  aatgagcag  240
tgcctcact  tcgacaagc  ctagacatg  tcttggacc  ggaacctga  gaagagctg  300
aagacaacc  caaccagag  gacttgatt  agcaggcgg  cgagatgct  tatgggttg  360
tccacgccc  ctacatcct  accaaccgg  gcattgcac  aatgttgga  aagtaccag  420
aaggagact  tggctactg  cctcgagta  actgtgaga  ccagccgat  cttcccatc  480
gcctttcgg  catcccagg  gaggccatg  tgaagctct  ctgccccaa  tgcatggac  540
tgtacacac  caagtcctc  aggcaccac  acacggatg  cgcatactt  ggcactggt  600
tccctcaca  gctcttcat  gtgcatccc  agtaccggc  caagcggcc  gccaaccag  660
ttgtgccca  gctctacgg  ttcaagatc  atccaatgg  ctaccagct  cagctccaa  720
ccgccagca  cttcaagag  ccagtcaag  cgattcgct  agtgccctc  cacctcctc  780
gcctgtgac  ccaccgtcc  tccgctgcc  ccctttcag  aagtctatg  tttttagtt  840
aaattaaag  aattgttac  gtggtgggg  tatgaaata  aggaagaga  ggctaaaaa  900
aaaaaaaaa  accgaattc  gcatctcac  taggtgtat  cagctgcac  ttaccaatg  960
ctgcagaac  cccaatcat  acctctagt  ctttatagc  aaagtgtaa  gtggtacct  1020
ggtgaccag  attgccatg  ttacatcca  ttgcgtaat  aagcagctg  gcaactgct  1080
ttctaacag  tgaacagct  catgcatct  cagcaggca  ggattgtct  ttgtctatg  1140
tcctcagtg  gttcactta  agtatttct  gagtttgag  ccttgccgt  atagagcca  1200
gtagggaat  cactgattg  atgttaccc  aagcgtcat  aaaccttcc  acacggtga  1260
ctatttaat  gtcttgttt  ttgacatga  aaattaaca  tcttagagt  acatctcga  1320
aaaagcatt  gtgatagat  agccctttg  gccttgtgg  taaattttt  tggctttgt  1380
taactttca  aggttatat  tgcactaac  ttttttgat  gctaagtag  ctttaaatt  1440
cagtaaatt  tttcaaata  aactggctg  aaaatatat  ttgaattag  gttgttcac  1500
ttttcatag  tacttatgt  tttttccca  taatttatt  cacatctct  ccagtgaac  1560
cagcccatc  ctagaaaat  accttgtcc  gatttcagt  tcaactatt  gttttaaag  1620
tcactgttg  ataagagga  gtggtggtg  attttaaat  gactttcat  tgcttttaa  1680
atatgacag  tctccttga  aatgtactt  tatttgatc  caagttgta  aaaaccaat  1740
aatttgtgt  actttgatt  cagtagtat  ttatgcata  tgattccat  ttatatgca  1800
actagttag  caactgttt  cttagttac  agcttcact  ttgtgcagt  aaaaaaaca  1860
aagtaggct  cagtctgtg  catgttgat  tacagtttc  gaaattgtt  tacaagact  1920
tgataataa  acccttaaa  tcacaaaaa  aaaaaaaaa  aacc  1964



<210> 2944
<211> 215
<212> PRT
<213> Rattus norvegicus
<308> P13862
<400> 2944

Met Ser Ser Ser Glu Glu Val Ser Trp Ile Ser Trp Phe Cys Gly Leu 
  1               5                  10                  15
Arg Gly Asn Glu Phe Phe Cys Glu Val Asp Glu Asp Tyr Ile Gln Asp 
             20                  25                  30
Lys Phe Asn Leu Thr Gly Leu Asn Glu Gln Val Pro His Tyr Arg Gln 
         35                  40                  45
Ala Leu Asp Met Ile Leu Asp Leu Glu Pro Asp Glu Glu Leu Glu Asp 
     50                  55                  60
Asn Pro Asn Gln Ser Asp Leu Ile Glu Gln Ala Ala Glu Met Leu Tyr 
 65                  70                  75                  80
Gly Leu Ile His Ala Arg Tyr Ile Leu Thr Asn Arg Gly Ile Ala Gln 
                 85                  90                  95
Met Leu Glu Lys Tyr Gln Gln Gly Asp Phe Gly Tyr Cys Pro Arg Val 
             100                105                110
Tyr Cys Glu Asn Gln Pro Met Leu Pro Ile Gly Leu Ser Asp Ile Pro 
         115                120                125
Gly Glu Ala Met Val Lys Leu Tyr Cys Pro Lys Cys Met Asp Val Tyr 
     130                135                140
Thr Pro Lys Ser Ser Arg His His His Thr Asp Gly Ala Tyr Phe Gly 
 145                150                155                160
Thr Gly Phe Pro His Met Leu Phe Met Val His Pro Glu Tyr Arg Pro 
                 165                170                175
Lys Arg Pro Ala Asn Gln Phe Val Pro Arg Leu Tyr Gly Phe Lys Ile 
             180                185                190
His Pro Met Ala Tyr Gln Leu Gln Leu Gln Ala Ala Ser Asn Phe Lys 
         195                200                205
Ser Pro Val Lys Thr Ile Arg 
     210                215



<210> 2945
<211> 648
<212> DNA
<213> Homo sapiens
<308> NM_001320
<400> 2945

atgagcagc  cagaggagg  gtcctggat  tcctggttc  gtgggctcc  tggcaatga  60
ttcttctgt  aagtggatg  agactacat  caggacaaa  ttaatctta  tggactcaa  120
gagcaggtc  ctcactacc  acaagctct  gacatgatc  tggacctgg  gcctgatga  180
gaactggaa  acaacccca  ccagagtga  ctgattgag  aggcagccg  gatgcttta  240
ggattgatc  acgcccgct  catccttac  aaccgtggc  tcgcccaga  gttggaaaa  300
taccagcaa  gagactttg  ttactgtcc  cgtgtgtac  gtgagaacc  gccaatgct  360
cccattggc  tttcagaca  cccaggtga  gccatggtg  agctctact  ccccaagtg  420
atggatgtg  acacaccca  gtcatcaag  caccatcac  cggatggcg  ctacttcgg  480
actggtttc  ctcacatgc  cttcatggt  catcccgag  accggccca  gagacctgc  540
aaccagttt  tgcccaggc  ctacggttt  aagatccat  cgatggcct  ccagctgca  600
ctccaagcc  ccagcaact  caagagccc  gtcaagacg  ttcgctga  648



<210> 2946
<211> 215
<212> PRT
<213> Homo sapiens
<308> P13862
<400> 2946

Met Ser Ser Ser Glu Glu Val Ser Trp Ile Ser Trp Phe Cys Gly Leu 
  1               5                  10                  15
Arg Gly Asn Glu Phe Phe Cys Glu Val Asp Glu Asp Tyr Ile Gln Asp 
             20                  25                  30
Lys Phe Asn Leu Thr Gly Leu Asn Glu Gln Val Pro His Tyr Arg Gln 
         35                  40                  45
Ala Leu Asp Met Ile Leu Asp Leu Glu Pro Asp Glu Glu Leu Glu Asp 
     50                  55                  60
Asn Pro Asn Gln Ser Asp Leu Ile Glu Gln Ala Ala Glu Met Leu Tyr 
 65                  70                  75                  80
Gly Leu Ile His Ala Arg Tyr Ile Leu Thr Asn Arg Gly Ile Ala Gln 
                 85                  90                  95
Met Leu Glu Lys Tyr Gln Gln Gly Asp Phe Gly Tyr Cys Pro Arg Val 
             100                105                110
Tyr Cys Glu Asn Gln Pro Met Leu Pro Ile Gly Leu Ser Asp Ile Pro 
         115                120                125
Gly Glu Ala Met Val Lys Leu Tyr Cys Pro Lys Cys Met Asp Val Tyr 
     130                135                140
Thr Pro Lys Ser Ser Arg His His His Thr Asp Gly Ala Tyr Phe Gly 
 145                150                155                160
Thr Gly Phe Pro His Met Leu Phe Met Val His Pro Glu Tyr Arg Pro 
                 165                170                175
Lys Arg Pro Ala Asn Gln Phe Val Pro Arg Leu Tyr Gly Phe Lys Ile 
             180                185                190
His Pro Met Ala Tyr Gln Leu Gln Leu Gln Ala Ala Ser Asn Phe Lys 
         195                200                205
Ser Pro Val Lys Thr Ile Arg 
     210                215



<210> 2947
<211> 1964
<212> DNA
<213> Rattus norvegicus
<308> L15619
<400> 2947

ggctgccgc  gcccggtcg  ctttctgcg  tgtagcggt  tctgccgtt  cttggaagc  60
cagctcccc  tccccgccc  agtcccagt  cccgtccgg  cgcggacat  aagatgagt  120
gctctgagg  ggtgtcctg  atttcctgg  tctgtgggc  ccgtggtaa  gaattcttc  180
gtgaggtgg  tgaagacta  atccaggac  aatttaatc  tactggact  aatgagcag  240
tgcctcact  tcgacaagc  ctagacatg  tcttggacc  ggaacctga  gaagagctg  300
aagacaacc  caaccagag  gacttgatt  agcaggcgg  cgagatgct  tatgggttg  360
tccacgccc  ctacatcct  accaaccgg  gcattgcac  aatgttgga  aagtaccag  420
aaggagact  tggctactg  cctcgagta  actgtgaga  ccagccgat  cttcccatc  480
gcctttcgg  catcccagg  gaggccatg  tgaagctct  ctgccccaa  tgcatggac  540
tgtacacac  caagtcctc  aggcaccac  acacggatg  cgcatactt  ggcactggt  600
tccctcaca  gctcttcat  gtgcatccc  agtaccggc  caagcggcc  gccaaccag  660
ttgtgccca  gctctacgg  ttcaagatc  atccaatgg  ctaccagct  cagctccaa  720
ccgccagca  cttcaagag  ccagtcaag  cgattcgct  agtgccctc  cacctcctc  780
gcctgtgac  ccaccgtcc  tccgctgcc  ccctttcag  aagtctatg  tttttagtt  840
aaattaaag  aattgttac  gtggtgggg  tatgaaata  aggaagaga  ggctaaaaa  900
aaaaaaaaa  accgaattc  gcatctcac  taggtgtat  cagctgcac  ttaccaatg  960
ctgcagaac  cccaatcat  acctctagt  ctttatagc  aaagtgtaa  gtggtacct  1020
ggtgaccag  attgccatg  ttacatcca  ttgcgtaat  aagcagctg  gcaactgct  1080
ttctaacag  tgaacagct  catgcatct  cagcaggca  ggattgtct  ttgtctatg  1140
tcctcagtg  gttcactta  agtatttct  gagtttgag  ccttgccgt  atagagcca  1200
gtagggaat  cactgattg  atgttaccc  aagcgtcat  aaaccttcc  acacggtga  1260
ctatttaat  gtcttgttt  ttgacatga  aaattaaca  tcttagagt  acatctcga  1320
aaaagcatt  gtgatagat  agccctttg  gccttgtgg  taaattttt  tggctttgt  1380
taactttca  aggttatat  tgcactaac  ttttttgat  gctaagtag  ctttaaatt  1440
cagtaaatt  tttcaaata  aactggctg  aaaatatat  ttgaattag  gttgttcac  1500
ttttcatag  tacttatgt  tttttccca  taatttatt  cacatctct  ccagtgaac  1560
cagcccatc  ctagaaaat  accttgtcc  gatttcagt  tcaactatt  gttttaaag  1620
tcactgttg  ataagagga  gtggtggtg  attttaaat  gactttcat  tgcttttaa  1680
atatgacag  tctccttga  aatgtactt  tatttgatc  caagttgta  aaaaccaat  1740
aatttgtgt  actttgatt  cagtagtat  ttatgcata  tgattccat  ttatatgca  1800
actagttag  caactgttt  cttagttac  agcttcact  ttgtgcagt  aaaaaaaca  1860
aagtaggct  cagtctgtg  catgttgat  tacagtttc  gaaattgtt  tacaagact  1920
tgataataa  acccttaaa  tcacaaaaa  aaaaaaaaa  aacc  1964



<210> 2948
<211> 215
<212> PRT
<213> Rattus norvegicus
<308> P13862
<400> 2948

Met Ser Ser Ser Glu Glu Val Ser Trp Ile Ser Trp Phe Cys Gly Leu 
  1               5                  10                  15
Arg Gly Asn Glu Phe Phe Cys Glu Val Asp Glu Asp Tyr Ile Gln Asp 
             20                  25                  30
Lys Phe Asn Leu Thr Gly Leu Asn Glu Gln Val Pro His Tyr Arg Gln 
         35                  40                  45
Ala Leu Asp Met Ile Leu Asp Leu Glu Pro Asp Glu Glu Leu Glu Asp 
     50                  55                  60
Asn Pro Asn Gln Ser Asp Leu Ile Glu Gln Ala Ala Glu Met Leu Tyr 
 65                  70                  75                  80
Gly Leu Ile His Ala Arg Tyr Ile Leu Thr Asn Arg Gly Ile Ala Gln 
                 85                  90                  95
Met Leu Glu Lys Tyr Gln Gln Gly Asp Phe Gly Tyr Cys Pro Arg Val 
             100                105                110
Tyr Cys Glu Asn Gln Pro Met Leu Pro Ile Gly Leu Ser Asp Ile Pro 
         115                120                125
Gly Glu Ala Met Val Lys Leu Tyr Cys Pro Lys Cys Met Asp Val Tyr 
     130                135                140
Thr Pro Lys Ser Ser Arg His His His Thr Asp Gly Ala Tyr Phe Gly 
 145                150                155                160
Thr Gly Phe Pro His Met Leu Phe Met Val His Pro Glu Tyr Arg Pro 
                 165                170                175
Lys Arg Pro Ala Asn Gln Phe Val Pro Arg Leu Tyr Gly Phe Lys Ile 
             180                185                190
His Pro Met Ala Tyr Gln Leu Gln Leu Gln Ala Ala Ser Asn Phe Lys 
         195                200                205
Ser Pro Val Lys Thr Ile Arg 
     210                215



<210> 2949
<211> 648
<212> DNA
<213> Homo sapiens
<308> NM_001320
<400> 2949

atgagcagc  cagaggagg  gtcctggat  tcctggttc  gtgggctcc  tggcaatga  60
ttcttctgt  aagtggatg  agactacat  caggacaaa  ttaatctta  tggactcaa  120
gagcaggtc  ctcactacc  acaagctct  gacatgatc  tggacctgg  gcctgatga  180
gaactggaa  acaacccca  ccagagtga  ctgattgag  aggcagccg  gatgcttta  240
ggattgatc  acgcccgct  catccttac  aaccgtggc  tcgcccaga  gttggaaaa  300
taccagcaa  gagactttg  ttactgtcc  cgtgtgtac  gtgagaacc  gccaatgct  360
cccattggc  tttcagaca  cccaggtga  gccatggtg  agctctact  ccccaagtg  420
atggatgtg  acacaccca  gtcatcaag  caccatcac  cggatggcg  ctacttcgg  480
actggtttc  ctcacatgc  cttcatggt  catcccgag  accggccca  gagacctgc  540
aaccagttt  tgcccaggc  ctacggttt  aagatccat  cgatggcct  ccagctgca  600
ctccaagcc  ccagcaact  caagagccc  gtcaagacg  ttcgctga  648



<210> 2950
<211> 215
<212> PRT
<213> Homo sapiens
<308> P13862
<400> 2950

Met Ser Ser Ser Glu Glu Val Ser Trp Ile Ser Trp Phe Cys Gly Leu 
  1               5                  10                  15
Arg Gly Asn Glu Phe Phe Cys Glu Val Asp Glu Asp Tyr Ile Gln Asp 
             20                  25                  30
Lys Phe Asn Leu Thr Gly Leu Asn Glu Gln Val Pro His Tyr Arg Gln 
         35                  40                  45
Ala Leu Asp Met Ile Leu Asp Leu Glu Pro Asp Glu Glu Leu Glu Asp 
     50                  55                  60
Asn Pro Asn Gln Ser Asp Leu Ile Glu Gln Ala Ala Glu Met Leu Tyr 
 65                  70                  75                  80
Gly Leu Ile His Ala Arg Tyr Ile Leu Thr Asn Arg Gly Ile Ala Gln 
                 85                  90                  95
Met Leu Glu Lys Tyr Gln Gln Gly Asp Phe Gly Tyr Cys Pro Arg Val 
             100                105                110
Tyr Cys Glu Asn Gln Pro Met Leu Pro Ile Gly Leu Ser Asp Ile Pro 
         115                120                125
Gly Glu Ala Met Val Lys Leu Tyr Cys Pro Lys Cys Met Asp Val Tyr 
     130                135                140
Thr Pro Lys Ser Ser Arg His His His Thr Asp Gly Ala Tyr Phe Gly 
 145                150                155                160
Thr Gly Phe Pro His Met Leu Phe Met Val His Pro Glu Tyr Arg Pro 
                 165                170                175
Lys Arg Pro Ala Asn Gln Phe Val Pro Arg Leu Tyr Gly Phe Lys Ile 
             180                185                190
His Pro Met Ala Tyr Gln Leu Gln Leu Gln Ala Ala Ser Asn Phe Lys 
         195                200                205
Ser Pro Val Lys Thr Ile Arg 
     210                215



<210> 2951
<211> 2455
<212> DNA
<213> Rattus norvegicus
<308> L16764
<400> 2951

agagaagca  agaagcaga  caagcggcg  gttcccgaa  ctcgggcaa  accagcctc  60
cccagagca  ccccaccgc  aacgcaccc  tctccagag  ataccccag  ggaggccac  120
cttccccag  gcatccccg  cgccaagcg  aaccttcca  aagcagacc  cagcgacat  180
gccaagaaa  cagcgatcg  catcgacct  ggcaccacc  actcgtgcg  gggcgtgtt  240
cagcacggc  aggtggaga  catcgccaa  gaccagggc  accgcacga  ccccagcta  300
gtggccttc  ccgacaccg  gcggctcat  ggggacgcc  ccaagaacc  ggtggcgct  360
aacccgcag  acaccgtgt  cgacgcgaa  cggctgatc  gccgcaagt  cggcgaccc  420
gtggtgcag  cggacatga  gcactggcc  ttccaggtg  tgaacgacg  cgacaagcc  480
aaggtgcag  tgaactaca  gggcgagaa  cggtcgttc  acccggagg  gatctcgtc  540
atggtgctg  ccaagatga  ggagatcgc  gaggcgtac  tgggccacc  ggtgaccaa  600
gcggtgatc  ccgtgcccg  ctacttcaa  gactcgcag  ggcaggcca  caaggacgc  660
ggcgtgatc  cgggtctga  cgtgctgcg  atcatcaac  agcccacgg  ggccgccat  720
gcctatggg  tggaccgga  cggcaaggg  gagcgcaac  tgctcatct  cgacctggg  780
ggcggcacg  tcgacgtgt  catcctgac  atcgacgac  gcatcttcg  ggtgaaggc  840
acggcgggc  acaccgacc  gggcgggga  gacttcgac  accggctgg  gagccactt  900
gtggaggag  tcaagagga  gcacaagaa  gacatcagc  agaacaagc  cgcggtgcg  960
cgcctgcgc  cggcgtgcg  gagggccaa  aggacgctg  cgtccagca  ccaggccag  1020
ctggagatc  actctctgt  cgagggcat  gacttctac  cgtccatca  gcgggcgcg  1080
ttcgaggag  tgtgctcgg  cctgttccg  ggcacgctg  agcccgtgg  gaaggccct  1140
cgcgacgcc  agctggaca  ggcgcagat  cacgacctg  tgctggtgg  cggctcgac  1200
cgcatcccc  aggtgcaga  gctgctgca  gacttcttc  acgggcgcg  cctgaacaa  1260
agcatcaat  cggacgagg  ggtggccta  ggggcggcg  tgcaggcgg  catcctgat  1320
ggggacaag  cggagaacg  gcaggacct  ctgctgctg  acgtggcgc  gctgtcgct  1380
ggtctggag  ccgcgggcg  cgtgatgac  gcgctcatc  agcgcaact  caccatccc  1440
accaagcag  cgcagacct  caccaccta  tcggacaac  agcccgggg  gctgatcca  1500
gtgtacgag  gcgagaggg  catgacgcg  gacaacaac  tgctggggc  cttcgagtt  1560
agcggcatc  cgccggctc  caggggcgt  ccccagatc  aggtgacct  cgacatcga  1620
gccaacggc  tcctgaacg  cacggccac  gacaagagc  ccggcaagg  caacaagat  1680
accatcacc  acgacaagg  ccgcctgag  aaggaggag  tcgagcgca  ggtgcagga  1740
gccgagcgc  acaaggcgg  ggacgaggt  cagcgcgag  gggtggctg  caagaatgc  1800
ctcgagtcc  acgccttca  tatgaagag  gccgtggag  acgagggtc  caagggcaa  1860
atcagcgag  ctgacaaga  gaaggtgct  gacaagtgc  aggaggtca  ctcctggct  1920
gactctaac  cgctggctg  gaaagagga  ttcgtgcac  agcgggagg  gctggagcg  1980
gtgtgcaac  cgatcatca  cgggctgta  cagggtgcg  gtgctcccg  ggctggggg  2040
ttcggggcc  aggcgccca  gggaggctc  gggtcgggg  ccaccatcg  ggaggtgga  2100
tagaggctt  tctggctct  agggtgttg  ctagagaca  actcttgat  gctgctggt  2160
cacgattct  atcaagtta  tccttctct  cggagttca  tttaaagtt  cagcctttt  2220
tacggtaat  gatttgagt  tgttacatt  tgtatgctc  tgggttttt  atatattca  2280
attaaggtt  catgttctt  gcgtttaat  taagtagct  tgtaaaaat  gtgtttcct  2340
cctgcgaac  cctcagcac  gccaccctg  gtacagttt  ttccttgca  ccctacaaa  2400
tgagaaaaa  agttatctt  tgtaactta  acattcaaa  taaaatgtt  caagt  2455



<210> 2952
<211> 641
<212> PRT
<213> Rattus norvegicus
<308> Q07439
<400> 2952

Met Ala Lys Lys Thr Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
  1               5                  10                  15
Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
             20                  25                  30
Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
         35                  40                  45
Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
     50                  55                  60
Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
 65                  70                  75                  80
Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Val Asn 
                 85                  90                  95
Asp Gly Asp Lys Pro Lys Val Gln Val Asn Tyr Lys Gly Glu Asn Arg 
             100                105                110
Ser Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
         115                120                125
Glu Ile Ala Glu Ala Tyr Leu Gly His Pro Val Thr Asn Ala Val Ile 
     130                135                140
Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
 145                150                155                160
Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                 165                170                175
Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
             180                185                190
Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
         195                200                205
Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
     210                215                220
Asp Thr Asp Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Ser His 
 225                230                235                240
Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                 245                250                255
Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
             260                265                270
Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
         275                280                285
Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
     290                295                300
Leu Cys Ser Asp Leu Phe Arg Gly Thr Leu Glu Pro Val Glu Lys Ala 
 305                310                315                320
Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                 325                330                335
Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
             340                345                350
Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
         355                360                365
Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
     370                375                380
Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
 385                390                395                400
Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                 405                410                415
Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
             420                425                430
Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
         435                440                445
Met Thr Arg Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
     450                455                460
Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
 465                470                475                480
Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                 485                490                495
Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
             500                505                510
Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Arg Tyr Lys Ala Glu 
         515                520                525
Asp Glu Val Gln Arg Glu Arg Val Ala Ala Lys Asn Ala Leu Glu Ser 
     530                535                540
Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
 545                550                555                560
Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                 565                570                575
Val Ile Ser Trp Leu Asp Ser Asn Thr Leu Ala Glu Lys Glu Glu Phe 
             580                585                590
Val His Lys Arg Glu Glu Leu Glu Arg Val Cys Asn Pro Ile Ile Ser 
         595                600                605
Gly Leu Tyr Gln Gly Ala Gly Ala Pro Gly Ala Gly Gly Phe Gly Ala 
     610                615                620
Gln Ala Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
 625                630                635                640
Asp 
                 645



<210> 2953
<211> 2388
<212> DNA
<213> Homo sapiens
<308> BC002453
<400> 2953

ggcacgagg  ctttttcga  agtgactcc  gttgtccca  ggcttccca  agcgaacct  60
tgcggctgc  ggcaccggc  cgtcgagtt  ccggcgtcc  gaaggaccg  gctcttctc  120
cggatccag  gttccgttt  cagccccca  tctcagagc  gagccgaca  agagcaggg  180
accggcatg  ccaaagccg  ggcgatcgg  atcgacctg  gcaccacct  ctcctgcgt  240
ggggtgttc  aacacggca  ggtggagat  atcgccaac  accagggca  ccgcaccac  300
cccagctac  tggccttca  ggacaccga  cggctcatc  gggatgcgg  caagaacca  360
gtggcgctg  acccgcaga  caccgtgtt  gacgcgaag  ggctgatcg  ccgcaagtt  420
ggcgacccg  tggtgcagt  ggacatgaa  cactggcct  tccaggtga  caacgacgg  480
gacaagccc  aggtgcagg  gagctacaa  ggggagacc  aggcattct  ccccgagga  540
atctcgtcc  tggtgctga  caagatgaa  gagatcgcc  aggcgtacc  gggctaccc  600
gtgaccaac  cggtgatca  cgtgccggc  tacttcaac  actcgcagc  ccaggccac  660
aaggatgcg  gtgtgatcg  ggggctcaa  gtgctgcgg  tcatcaacg  gcccacggc  720
gccgccatc  cctacggcc  ggacagaac  ggcaagggg  agcgcaacg  gctcatctt  780
gacctgggc  ggggcacct  cgacgtgtc  atcctgacg  tcgacgacg  catcttcga  840
gtgaaggcc  cggccgggg  cacccacct  ggtggggag  actttgaca  caggctggt  900
aaccacttc  tggaggagt  caagagaaa  cacaagaag  acatcagcc  gaacaagcg  960
gccgtgagg  ggctgcgca  cgcctgcga  agggccaag  ggaccctgt  gtccagcac  1020
caggccagc  tggagatcg  ctccctgtt  gagggcatc  acttctaca  gtccatcac  1080
agggcgagg  tcgaggagc  gtgctccga  ctgttccga  gcaccctgg  gcccgtgga  1140
aaggctctg  gcgacgcca  gctggacaa  gcccagatt  acgacctgg  cctggtcgg  1200
ggctccacc  gcatcccca  ggtgcagaa  ctgctgcag  acttcttca  cgggcgcga  1260
ctgaacaag  gcatcaacc  cgacgaggc  gtggcctac  gggcggcgg  gcaggcggc  1320
atcctgatg  gggacaagt  cgagaacgt  caggacctg  tgctgctgg  cgtggctcc  1380
ctgtcgctg  ggctggaga  ggccggagg  gtgatgact  ccctgatca  gcgcaactc  1440
accatcccc  ccaagcaga  gcagatctt  accacctac  ccgacaacc  acccggggt  1500
ctgatccag  tgtacgagg  cgagagggc  atgacgaaa  acaacaatc  gttggggcg  1560
ttcgagctg  gcggcatcc  tccggcccc  aggggcgtg  cccagatcg  ggtgacctt  1620
gacatcgat  ccaacggca  cctgaacgt  acggccacg  acaagagca  cggcaaggc  1680
aacaagatc  ccatcacca  cgacaaggg  cgcctgagc  aggaggaga  cgagcgcat  1740
gtgcaggag  cggagaagt  caaagcgga  gacgaggtg  agcgcgaga  ggtgtcagc  1800
aagaacgcc  tggagtcct  cgccttcaa  atgaagagc  ccgtggagg  tgaggggct  1860
aagggcaag  tcagcgagg  ggacaagaa  aaggttctg  acaagtgtc  agaggtcat  1920
tcgtggctg  acgccaaca  cttggccga  aaggacgag  ttgagcaca  gaggaagga  1980
ctggagcag  tgtgtaacc  catcatcag  ggactgtac  agggtgccg  tggtcccgg  2040
cctgggggc  tcggggctc  gggtcccaa  ggagggtct  ggtcaggcc  caccattga  2100
gaggtggat  aggggcctt  ccaagattg  tgtttttgt  ttggagctt  aagactttg  2160
atttcctag  atttctgtt  gtcagttct  aatttcctg  gtttgcaat  ttgaaattt  2220
ttggtgaag  actgaactt  ctttttttc  ggtttctac  tgcagagat  aatttatac  2280
gccatctta  gactatttc  tctttttaa  acacttaac  caggccatt  tttaagttg  2340
ttacttcaa  gtaaataaa  tttaaaatt  aaaaaaaaa  aaaaaaaa  2388



<210> 2954
<211> 105
<212> PRT
<213> Homo sapiens
<308> P01842
<400> 2954

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
  1               5                  10                  15
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
             20                  25                  30
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
         35                  40                  45
Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
     50                  55                  60
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
 65                  70                  75                  80
His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                 85                  90                  95
Lys Thr Val Ala Pro Thr Glu Cys Ser 
             100                105



<210> 2955
<211> 455
<212> DNA
<213> Rattus norvegicus
<308> L17077
<400> 2955

gatctcctt  tcgctagag  ctccttcac  gcatggctg  cctggtgct  ttgctctgc  60
tggtgacat  tccaacctg  gtcctgtcc  aggtgcagt  gaaggaatc  ggacctggt  120
tggtgcagc  ctcacagac  ctgtccctc  cctgcactg  ctctgggtt  tcactaacc  180
acaacaatg  gaactgggt  cgacaggct  caggaagag  tctggagtg  atgggagga  240
tctgggctg  tggagccac  gattacaat  cagctctca  atcccgact  accatcact  300
gggacacct  caagagcca  gttttctta  aaatgcaca  tctgcaatc  gaagacaca  360
ccacttact  ctgtgccag  gacgggggc  atagcagct  taccctcta  gctatggat  420
cctggggtc  aggaacttc  gtcactgtc  cctca  455



<210> 2956
<211> 831
<212> DNA
<213> Rattus norvegicus
<308> L17127
<400> 2956

ggcacgagt  actaagatg  aagcgtttt  ggagtcacg  actggccac  gggcggagg  60
ccggggcag  tttaccggc  tcccgtcac  cccagctgc  tcatggatc  gatgtctgc  120
cctgcgagg  ccatcactc  gacccagaa  ccgatgctg  ctgggacat  cgtactagg  180
gtgaagttc  actgcggag  ggtgattgc  gcagacatg  tgggctcct  cggctccct  240
gctcgtttc  gcattatct  tcgtattat  cgagtcaac  acagcacta  gctaggtgc  300
tcaggagac  atgctgatt  ccagtattt  aagcaagtt  tcggccaga  ggtgattga  360
gaggagctg  tcggagatg  acatagcta  agtcctaga  ctatccatt  atggttgac  420
agggccatg  acagtcgcc  ctccaagat  aaccctctg  ggaacacca  ggtcattgg  480
ggctatgct  gtggagaaa  ctttcttgg  tatgtggac  tgcttggtg  agcttatga  540
gccccttca  tagccactg  ttatggtgc  tacttggct  agcctctgc  tcgagaagt  600
ctagagaag  aaccggtgc  gagtcagac  gaggcccga  agcttgtgg  gcgctgcat  660
cgagtgctg  actaccgag  cgctcgttc  tataaccgg  ttcaagttg  tactgtaac  720
gaaaaaggt  tggagatag  aggaccact  tcagcacag  ccaactggg  cattgctca  780
atgatcagt  gctttgaat  aaatccaga  gaagtgtcc  gagttaagc  t  831



<210> 2957
<211> 263
<212> PRT
<213> Rattus norvegicus
<308> P34067
<400> 2957

Met Glu Ala Phe Trp Glu Ser Arg Thr Gly His Trp Ala Gly Gly Pro 
  1               5                  10                  15
Ala Pro Gly Gln Phe Tyr Arg Val Pro Ser Thr Pro Ser Cys Leu Met 
             20                  25                  30
Asp Pro Met Ser Ala Pro Ala Arg Pro Ile Thr Arg Thr Gln Asn Pro 
         35                  40                  45
Met Val Thr Gly Thr Ser Val Leu Gly Val Lys Phe Asp Cys Gly Val 
     50                  55                  60
Val Ile Ala Ala Asp Met Leu Gly Ser Tyr Gly Ser Leu Ala Arg Phe 
 65                  70                  75                  80
Arg Asn Ile Ser Arg Ile Met Arg Val Asn Asp Ser Thr Met Leu Gly 
                 85                  90                  95
Ala Ser Gly Asp Tyr Ala Asp Phe Gln Tyr Leu Lys Gln Val Leu Gly 
             100                105                110
Gln Met Val Ile Asp Glu Glu Leu Phe Gly Asp Gly His Ser Tyr Ser 
         115                120                125
Pro Arg Ala Ile His Ser Trp Leu Thr Arg Ala Met Tyr Ser Arg Arg 
     130                135                140
Ser Lys Met Asn Pro Leu Trp Asn Thr Lys Val Ile Gly Gly Tyr Ala 
 145                150                155                160
Gly Gly Glu Ser Phe Leu Gly Tyr Val Asp Met Leu Gly Val Ala Tyr 
                 165                170                175
Glu Ala Pro Ser Leu Ala Thr Gly Tyr Gly Ala Tyr Leu Ala Gln Pro 
             180                185                190
Leu Leu Arg Glu Val Leu Glu Lys Gln Pro Val Leu Ser Gln Thr Glu 
         195                200                205
Ala Arg Glu Leu Val Glu Arg Cys Met Arg Val Leu Tyr Tyr Arg Asp 
     210                215                220
Ala Arg Ser Tyr Asn Arg Phe Gln Val Ala Thr Val Thr Glu Lys Gly 
 225                230                235                240
Val Glu Ile Glu Gly Pro Leu Ser Ala Gln Thr Asn Trp Asp Ile Ala 
                 245                250                255
His Met Ile Ser Gly Phe Glu 
             260



<210> 2958
<211> 974
<212> DNA
<213> Homo sapiens
<308> BC008314
<400> 2958

gagagagag  gaactagtc  cgagttttt  ttttttttt  ttgctaccg  gactaagat  60
gaagcgttt  tggggtcgc  gtccggact  tgggcgggg  gtccggccc  aggacagtt  120
taccgcatt  cgtccactc  cgattcctt  atggatccg  cgtctgcac  ttacagagg  180
ccaatcacg  ggacccaga  ccccatggt  accgggacc  cagtcctcg  cgttaagtt  240
gagggcgga  tggtgattg  cgcagacat  ctgggatcc  acggctcct  ggctcgttt  300
cgcaacatc  ctcgcatta  gcgagtcaa  aacagtacc  tgctgggtg  ctctggcga  360
tacgctgat  tccagtatt  gaagcaagt  ctcggccag  tggtgattg  tgaggagct  420
ctgggagat  gacacagct  tagtcctag  gctattcat  catggctga  cagggccat  480
tacagccgg  gctcgaaga  gaacccttt  tggaacacc  tggtcatcg  aggctatgc  540
gatggagag  gcttcctcg  ttatgtgga  atgcttggt  tagcctatg  agccccttc  600
ctggccact  gttatggtg  atacttggc  cagcctctg  tgcgagaag  tctggagaa  660
cagccagtg  taagccaga  cgaggcccg  gacttagta  aacgctgca  gcgagtgct  720
tactaccga  atgcccgtt  ttacaaccg  tttcaaatc  ccactgtca  cgaaaaagg  780
gttgaaata  agggaccat  gtctacaga  accaactgg  atattgccc  catgatcag  840
ggctttgaa  gaaatacag  tgcattatc  agaactgaa  ttgccctac  tttaacttt  900
aacttggct  gttcaaaga  agactcttc  tttgtaaag  aaataaatt  ttcaaaaaa  960
aaaaaaaaa  aaaa  974



<210> 2959
<211> 264
<212> PRT
<213> Homo sapiens
<308> P28070
<400> 2959

Met Glu Ala Phe Leu Gly Ser Arg Ser Gly Leu Trp Ala Gly Gly Pro 
  1               5                  10                  15
Ala Pro Gly Gln Phe Tyr Arg Ile Pro Ser Thr Pro Asp Ser Phe Met 
             20                  25                  30
Asp Pro Ala Ser Ala Leu Tyr Arg Gly Pro Ile Thr Arg Thr Gln Asn 
         35                  40                  45
Pro Met Val Thr Gly Thr Ser Val Leu Gly Val Lys Phe Glu Gly Gly 
     50                  55                  60
Val Val Ile Ala Ala Asp Met Leu Gly Ser Tyr Gly Ser Leu Ala Arg 
 65                  70                  75                  80
Phe Arg Asn Ile Ser Arg Ile Met Arg Val Asn Asn Ser Thr Met Leu 
                 85                  90                  95
Gly Ala Ser Gly Asp Tyr Ala Asp Phe Gln Tyr Leu Lys Gln Val Leu 
             100                105                110
Gly Gln Met Val Ile Asp Glu Glu Leu Leu Gly Asp Gly His Ser Tyr 
         115                120                125
Ser Pro Arg Ala Ile His Ser Trp Leu Thr Arg Ala Met Tyr Ser Arg 
     130                135                140
Arg Ser Lys Met Asn Pro Leu Trp Asn Thr Met Val Ile Gly Gly Tyr 
 145                150                155                160
Ala Asp Gly Glu Ser Phe Leu Gly Tyr Val Asp Met Leu Gly Val Ala 
                 165                170                175
Tyr Glu Ala Pro Ser Leu Ala Thr Gly Tyr Gly Ala Tyr Leu Ala Gln 
             180                185                190
Pro Leu Leu Arg Glu Val Leu Glu Lys Gln Pro Val Leu Ser Gln Thr 
         195                200                205
Glu Ala Arg Asp Leu Val Glu Arg Cys Met Arg Val Leu Tyr Tyr Arg 
     210                215                220
Asp Ala Arg Ser Tyr Asn Arg Phe Gln Thr Ala Thr Val Thr Glu Lys 
 225                230                235                240
Gly Val Glu Ile Glu Gly Pro Leu Ser Thr Glu Thr Asn Trp Asp Ile 
                 245                250                255
Ala His Met Ile Ser Gly Phe Glu 
             260



<210> 2960
<211> 831
<212> DNA
<213> Rattus norvegicus
<308> L17127
<400> 2960

ggcacgagt  actaagatg  aagcgtttt  ggagtcacg  actggccac  gggcggagg  60
ccggggcag  tttaccggc  tcccgtcac  cccagctgc  tcatggatc  gatgtctgc  120
cctgcgagg  ccatcactc  gacccagaa  ccgatgctg  ctgggacat  cgtactagg  180
gtgaagttc  actgcggag  ggtgattgc  gcagacatg  tgggctcct  cggctccct  240
gctcgtttc  gcattatct  tcgtattat  cgagtcaac  acagcacta  gctaggtgc  300
tcaggagac  atgctgatt  ccagtattt  aagcaagtt  tcggccaga  ggtgattga  360
gaggagctg  tcggagatg  acatagcta  agtcctaga  ctatccatt  atggttgac  420
agggccatg  acagtcgcc  ctccaagat  aaccctctg  ggaacacca  ggtcattgg  480
ggctatgct  gtggagaaa  ctttcttgg  tatgtggac  tgcttggtg  agcttatga  540
gccccttca  tagccactg  ttatggtgc  tacttggct  agcctctgc  tcgagaagt  600
ctagagaag  aaccggtgc  gagtcagac  gaggcccga  agcttgtgg  gcgctgcat  660
cgagtgctg  actaccgag  cgctcgttc  tataaccgg  ttcaagttg  tactgtaac  720
gaaaaaggt  tggagatag  aggaccact  tcagcacag  ccaactggg  cattgctca  780
atgatcagt  gctttgaat  aaatccaga  gaagtgtcc  gagttaagc  t  831



<210> 2961
<211> 263
<212> PRT
<213> Rattus norvegicus
<308> P34067
<400> 2961

Met Glu Ala Phe Trp Glu Ser Arg Thr Gly His Trp Ala Gly Gly Pro 
  1               5                  10                  15
Ala Pro Gly Gln Phe Tyr Arg Val Pro Ser Thr Pro Ser Cys Leu Met 
             20                  25                  30
Asp Pro Met Ser Ala Pro Ala Arg Pro Ile Thr Arg Thr Gln Asn Pro 
         35                  40                  45
Met Val Thr Gly Thr Ser Val Leu Gly Val Lys Phe Asp Cys Gly Val 
     50                  55                  60
Val Ile Ala Ala Asp Met Leu Gly Ser Tyr Gly Ser Leu Ala Arg Phe 
 65                  70                  75                  80
Arg Asn Ile Ser Arg Ile Met Arg Val Asn Asp Ser Thr Met Leu Gly 
                 85                  90                  95
Ala Ser Gly Asp Tyr Ala Asp Phe Gln Tyr Leu Lys Gln Val Leu Gly 
             100                105                110
Gln Met Val Ile Asp Glu Glu Leu Phe Gly Asp Gly His Ser Tyr Ser 
         115                120                125
Pro Arg Ala Ile His Ser Trp Leu Thr Arg Ala Met Tyr Ser Arg Arg 
     130                135                140
Ser Lys Met Asn Pro Leu Trp Asn Thr Lys Val Ile Gly Gly Tyr Ala 
 145                150                155                160
Gly Gly Glu Ser Phe Leu Gly Tyr Val Asp Met Leu Gly Val Ala Tyr 
                 165                170                175
Glu Ala Pro Ser Leu Ala Thr Gly Tyr Gly Ala Tyr Leu Ala Gln Pro 
             180                185                190
Leu Leu Arg Glu Val Leu Glu Lys Gln Pro Val Leu Ser Gln Thr Glu 
         195                200                205
Ala Arg Glu Leu Val Glu Arg Cys Met Arg Val Leu Tyr Tyr Arg Asp 
     210                215                220
Ala Arg Ser Tyr Asn Arg Phe Gln Val Ala Thr Val Thr Glu Lys Gly 
 225                230                235                240
Val Glu Ile Glu Gly Pro Leu Ser Ala Gln Thr Asn Trp Asp Ile Ala 
                 245                250                255
His Met Ile Ser Gly Phe Glu 
             260



<210> 2962
<211> 974
<212> DNA
<213> Homo sapiens
<308> BC008314
<400> 2962

gagagagag  gaactagtc  cgagttttt  ttttttttt  ttgctaccg  gactaagat  60
gaagcgttt  tggggtcgc  gtccggact  tgggcgggg  gtccggccc  aggacagtt  120
taccgcatt  cgtccactc  cgattcctt  atggatccg  cgtctgcac  ttacagagg  180
ccaatcacg  ggacccaga  ccccatggt  accgggacc  cagtcctcg  cgttaagtt  240
gagggcgga  tggtgattg  cgcagacat  ctgggatcc  acggctcct  ggctcgttt  300
cgcaacatc  ctcgcatta  gcgagtcaa  aacagtacc  tgctgggtg  ctctggcga  360
tacgctgat  tccagtatt  gaagcaagt  ctcggccag  tggtgattg  tgaggagct  420
ctgggagat  gacacagct  tagtcctag  gctattcat  catggctga  cagggccat  480
tacagccgg  gctcgaaga  gaacccttt  tggaacacc  tggtcatcg  aggctatgc  540
gatggagag  gcttcctcg  ttatgtgga  atgcttggt  tagcctatg  agccccttc  600
ctggccact  gttatggtg  atacttggc  cagcctctg  tgcgagaag  tctggagaa  660
cagccagtg  taagccaga  cgaggcccg  gacttagta  aacgctgca  gcgagtgct  720
tactaccga  atgcccgtt  ttacaaccg  tttcaaatc  ccactgtca  cgaaaaagg  780
gttgaaata  agggaccat  gtctacaga  accaactgg  atattgccc  catgatcag  840
ggctttgaa  gaaatacag  tgcattatc  agaactgaa  ttgccctac  tttaacttt  900
aacttggct  gttcaaaga  agactcttc  tttgtaaag  aaataaatt  ttcaaaaaa  960
aaaaaaaaa  aaaa  974



<210> 2963
<211> 264
<212> PRT
<213> Homo sapiens
<308> P28070
<400> 2963

Met Glu Ala Phe Leu Gly Ser Arg Ser Gly Leu Trp Ala Gly Gly Pro 
  1               5                  10                  15
Ala Pro Gly Gln Phe Tyr Arg Ile Pro Ser Thr Pro Asp Ser Phe Met 
             20                  25                  30
Asp Pro Ala Ser Ala Leu Tyr Arg Gly Pro Ile Thr Arg Thr Gln Asn 
         35                  40                  45
Pro Met Val Thr Gly Thr Ser Val Leu Gly Val Lys Phe Glu Gly Gly 
     50                  55                  60
Val Val Ile Ala Ala Asp Met Leu Gly Ser Tyr Gly Ser Leu Ala Arg 
 65                  70                  75                  80
Phe Arg Asn Ile Ser Arg Ile Met Arg Val Asn Asn Ser Thr Met Leu 
                 85                  90                  95
Gly Ala Ser Gly Asp Tyr Ala Asp Phe Gln Tyr Leu Lys Gln Val Leu 
             100                105                110
Gly Gln Met Val Ile Asp Glu Glu Leu Leu Gly Asp Gly His Ser Tyr 
         115                120                125
Ser Pro Arg Ala Ile His Ser Trp Leu Thr Arg Ala Met Tyr Ser Arg 
     130                135                140
Arg Ser Lys Met Asn Pro Leu Trp Asn Thr Met Val Ile Gly Gly Tyr 
 145                150                155                160
Ala Asp Gly Glu Ser Phe Leu Gly Tyr Val Asp Met Leu Gly Val Ala 
                 165                170                175
Tyr Glu Ala Pro Ser Leu Ala Thr Gly Tyr Gly Ala Tyr Leu Ala Gln 
             180                185                190
Pro Leu Leu Arg Glu Val Leu Glu Lys Gln Pro Val Leu Ser Gln Thr 
         195                200                205
Glu Ala Arg Asp Leu Val Glu Arg Cys Met Arg Val Leu Tyr Tyr Arg 
     210                215                220
Asp Ala Arg Ser Tyr Asn Arg Phe Gln Thr Ala Thr Val Thr Glu Lys 
 225                230                235                240
Gly Val Glu Ile Glu Gly Pro Leu Ser Thr Glu Thr Asn Trp Asp Ile 
                 245                250                255
Ala His Met Ile Ser Gly Phe Glu 
             260



<210> 2964
<211> 1011
<212> DNA
<213> Rattus norvegicus
<308> L17318
<400> 2964

cactccaga  tcacctgca  gatgctggt  gtcctgctc  cagcagcct  gctagtcct  60
agctcagct  agggcgtag  tgaagaagt  gtctatgaa  actcatctc  gcagttaga  120
ttagagcag  agagccagg  acatggcca  catcatcca  aaccacctc  tggtggatt  180
cccccaaga  ctcctgctt  tgatgaaaa  ggtgatggt  atgataacg  tgatggtga  240
gatgatggc  gtggggatg  tgtaaacag  ccagagaga  caccgcagc  cggaggcaa  300
caccaccat  ctcaccatc  acccccagc  gcaggccct  agagacccc  acagcctgg  360
agtcctcaa  gcccgcccc  tcctggagg  ccacagcaa  gaccccctc  aggaccacc  420
ccacaagga  gccctcaga  acccccaca  cctggaagt  ctcaaggcc  gccccctcc  480
ggaggccca  agcaaagac  ccctcaagg  ccaccccca  agggaggcc  tcagagacc  540
ccacagcct  gaagtcctc  aggcccgcc  cctcctgga  gcccacagc  aagagcccc  600
caaggacca  ccccacagg  aggccctca  agaccccca  agcctggta  ccctcaagg  660
ccgcccccg  ctggaggcc  acagcaaag  ccccctcaa  gaccacccc  gcagggagg  720
cctcagaga  ccccgcagc  tggtagccc  caaggcccg  cccctcctg  aggccctca  780
caaagaccc  ctcaaggac  acccccaca  ggaggccct  agagaccac  tcaacctgg  840
aacccacaa  gaccacccc  gcagggagg  cagcaacag  caagtttcc  gtggtcatt  900
tctgcataa  catctggtt  ctgagcaga  agaaggtga  caaaagaca  atgccttca  960
tatcattcc  gtagaaaag  gattccaat  aaatattta  catacaaaa  a  1011



<210> 2965
<211> 296
<212> PRT
<213> Rattus norvegicus
<308> L17318
<400> 2965

Met Leu Val Val Leu Leu Thr Ala Ala Leu Leu Val Leu Ser Ser Ala 
  1               5                  10                  15
Gln Gly Val Asp Glu Glu Val Val Tyr Glu Asp Ser Ser Gln Gln Leu 
             20                  25                  30
Glu Leu Glu Gln Gln Ser Gln Gly His Gly Gln His His Pro Lys Pro 
         35                  40                  45
Pro Pro Gly Gly Leu Pro Pro Arg Pro Pro Ala Ser Asp Glu Asn Gly 
     50                  55                  60
Asp Gly Asp Asp Asn Asp Asp Gly Asp Asp Asp Gly Ser Gly Asp Asp 
 65                  70                  75                  80
Val Asn Arg Pro Glu Arg Pro Pro Gln His Gly Gly Asn His His His 
                 85                  90                  95
Pro His His Pro Pro Pro Ala Ala Gly Pro Gln Arg Pro Pro Gln Pro 
             100                105                110
Gly Ser Pro Gln Gly Pro Pro Pro Pro Gly Gly Pro Gln Gln Arg Pro 
         115                120                125
Pro Gln Gly Pro Pro Pro Gln Gly Gly Pro Gln Arg Pro Pro Gln Pro 
     130                135                140
Gly Ser Pro Gln Gly Pro Pro Pro Pro Gly Gly Pro Gln Gln Arg Pro 
 145                150                155                160
Pro Gln Gly Pro Pro Pro Gln Gly Gly Pro Gln Arg Pro Pro Gln Pro 
                 165                170                175
Gly Ser Pro Gln Gly Pro Pro Pro Pro Gly Gly Pro Gln Gln Arg Ala 
             180                185                190
Pro Gln Gly Pro Pro Pro Gln Gly Gly Pro Gln Arg Pro Pro Gln Pro 
         195                200                205
Gly Ser Pro Gln Gly Pro Pro Pro Pro Gly Gly Pro Gln Gln Arg Pro 
     210                215                220
Pro Gln Gly Pro Pro Pro Gln Gly Gly Pro Gln Arg Pro Pro Gln Pro 
 225                230                235                240
Gly Ser Pro Gln Gly Pro Pro Pro Pro Gly Gly Pro Gln Gln Arg Pro 
                 245                250                255
Pro Gln Gly Pro Pro Pro Gln Gly Gly Pro Gln Arg Pro Pro Gln Pro 
             260                265                270
Gly Asn Pro Gln Gly Pro Pro Gln Gln Gly Gly Gln Gln Gln Ser Ser 
         275                280                285
Phe Leu Trp Ser Phe Ser Ala Ter 
     290                295



<210> 2966
<211> 1970
<212> PRT
<213> Homo sapiens
<308> P24928
<400> 2966

Met His Gly Gly Gly Pro Pro Ser Gly Asp Ser Ala Cys Pro Leu Arg 
  1               5                  10                  15
Thr Ile Lys Arg Val Gln Phe Gly Val Leu Ser Pro Asp Glu Leu Lys 
             20                  25                  30
Arg Met Ser Val Thr Glu Gly Gly Ile Lys Tyr Pro Glu Thr Thr Glu 
         35                  40                  45
Gly Gly Arg Pro Lys Leu Gly Gly Leu Met Asp Pro Arg Gln Gly Val 
     50                  55                  60
Ile Glu Arg Thr Gly Arg Cys Gln Thr Cys Ala Gly Asn Met Thr Glu 
 65                  70                  75                  80
Cys Pro Gly His Phe Gly His Ile Glu Leu Ala Lys Pro Val Phe His 
                 85                  90                  95
Val Gly Phe Leu Val Lys Thr Met Lys Val Leu Arg Cys Val Cys Phe 
             100                105                110
Phe Cys Ser Lys Leu Leu Val Asp Ser Asn Asn Pro Lys Ile Lys Asp 
         115                120                125
Ile Leu Ala Lys Ser Lys Gly Gln Pro Lys Lys Arg Leu Thr His Val 
     130                135                140
Tyr Asp Leu Cys Lys Gly Lys Asn Ile Cys Glu Gly Gly Glu Glu Met 
 145                150                155                160
Asp Asn Lys Phe Gly Val Glu Gln Pro Glu Gly Asp Glu Asp Leu Thr 
                 165                170                175
Lys Glu Lys Gly His Gly Gly Cys Gly Arg Tyr Gln Pro Arg Ile Arg 
             180                185                190
Arg Ser Gly Leu Glu Leu Tyr Ala Glu Trp Lys His Val Asn Glu Asp 
         195                200                205
Ser Gln Glu Lys Lys Ile Leu Leu Ser Pro Glu Arg Val His Glu Ile 
     210                215                220
Phe Lys Arg Ile Ser Asp Glu Glu Cys Phe Val Leu Gly Met Glu Pro 
 225                230                235                240
Arg Tyr Ala Arg Pro Glu Trp Met Ile Val Thr Val Leu Pro Val Pro 
                 245                250                255
Pro Leu Ser Val Arg Pro Ala Val Val Met Gln Gly Ser Ala Arg Asn 
             260                265                270
Gln Asp Asp Leu Thr His Lys Leu Ala Asp Ile Val Lys Ile Asn Asn 
         275                280                285
Gln Leu Arg Arg Asn Glu Gln Asn Gly Ala Ala Ala His Val Ile Ala 
     290                295                300
Glu Asp Val Lys Leu Leu Gln Phe His Val Ala Thr Met Val Asp Asn 
 305                310                315                320
Glu Leu Pro Gly Leu Pro Arg Ala Met Gln Lys Ser Gly Arg Pro Leu 
                 325                330                335
Lys Ser Leu Lys Gln Arg Leu Lys Gly Lys Glu Gly Arg Val Arg Gly 
             340                345                350
Asn Leu Met Gly Lys Arg Val Asp Phe Ser Ala Arg Thr Val Ile Thr 
         355                360                365
Pro Asp Pro Asn Leu Ser Ile Asp Gln Val Gly Val Pro Arg Ser Ile 
     370                375                380
Ala Ala Asn Met Thr Phe Ala Glu Ile Val Thr Pro Phe Asn Ile Asp 
 385                390                395                400
Arg Leu Gln Glu Leu Val Arg Arg Gly Asn Ser Gln Tyr Pro Gly Ala 
                 405                410                415
Lys Tyr Ile Ile Arg Asp Asn Gly Asp Arg Ile Asp Leu Arg Phe His 
             420                425                430
Pro Lys Pro Ser Asp Leu His Leu Gln Thr Gly Tyr Lys Val Glu Arg 
         435                440                445
His Met Cys Asp Gly Asp Ile Val Ile Phe Asn Arg Gln Pro Thr Leu 
     450                455                460
His Lys Met Ser Met Met Gly His Arg Val Arg Ile Leu Pro Trp Ser 
 465                470                475                480
Thr Phe Arg Leu Asn Leu Ser Val Thr Thr Pro Tyr Asn Ala Asp Phe 
                 485                490                495
Asp Gly Asp Glu Met Asn Leu His Leu Pro Gln Ser Leu Glu Thr Arg 
             500                505                510
Ala Glu Ile Gln Glu Leu Ala Met Val Pro Arg Met Ile Val Thr Pro 
         515                520                525
Gln Ser Asn Arg Pro Val Met Gly Ile Val Gln Asp Thr Leu Thr Ala 
     530                535                540
Val Arg Lys Phe Thr Lys Arg Asp Val Phe Leu Glu Arg Gly Glu Val 
 545                550                555                560
Met Asn Leu Leu Met Phe Leu Ser Thr Trp Asp Gly Lys Val Pro Gln 
                 565                570                575
Pro Ala Ile Leu Lys Pro Arg Pro Leu Trp Thr Gly Lys Gln Ile Phe 
             580                585                590
Ser Leu Ile Ile Pro Gly His Ile Asn Cys Ile Arg Thr His Ser Thr 
         595                600                605
His Pro Asp Asp Glu Asp Ser Gly Pro Tyr Lys His Ile Ser Pro Gly 
     610                615                620
Asp Thr Lys Val Val Val Glu Asn Gly Glu Leu Ile Met Gly Ile Leu 
 625                630                635                640
Cys Lys Lys Ser Leu Gly Thr Ser Ala Gly Ser Leu Val His Ile Ser 
                 645                650                655
Tyr Leu Glu Met Gly His Asp Ile Thr Arg Leu Phe Tyr Ser Asn Ile 
             660                665                670
Gln Thr Val Ile Asn Asn Trp Leu Leu Ile Glu Gly His Thr Ile Gly 
         675                680                685
Ile Gly Asp Ser Ile Ala Asp Ser Lys Thr Tyr Gln Asp Ile Gln Asn 
     690                695                700
Thr Ile Lys Lys Ala Lys Gln Asp Val Ile Glu Val Ile Glu Lys Ala 
 705                710                715                720
His Asn Asn Glu Leu Glu Pro Thr Pro Gly Asn Thr Leu Arg Gln Thr 
                 725                730                735
Phe Glu Asn Gln Val Asn Arg Ile Leu Asn Asp Ala Arg Asp Lys Thr 
             740                745                750
Gly Ser Ser Ala Gln Lys Ser Leu Ser Glu Tyr Asn Asn Phe Lys Ser 
         755                760                765
Met Val Val Ser Gly Ala Lys Gly Ser Lys Ile Asn Ile Ser Gln Val 
     770                775                780
Ile Ala Val Val Gly Gln Gln Asn Val Glu Gly Lys Arg Ile Pro Phe 
 785                790                795                800
Gly Phe Lys His Arg Thr Leu Pro His Phe Ile Lys Asp Asp Tyr Gly 
                 805                810                815
Pro Glu Ser Arg Gly Phe Val Glu Asn Ser Tyr Leu Ala Gly Leu Thr 
             820                825                830
Pro Thr Glu Phe Phe Phe His Ala Met Gly Gly Arg Glu Gly Leu Ile 
         835                840                845
Asp Thr Ala Val Lys Thr Ala Glu Thr Gly Tyr Ile Gln Arg Arg Leu 
     850                855                860
Ile Lys Ser Met Glu Ser Val Met Val Lys Tyr Asp Ala Thr Val Arg 
 865                870                875                880
Asn Ser Ile Asn Gln Val Val Gln Leu Arg Tyr Gly Glu Asp Gly Leu 
                 885                890                895
Ala Gly Glu Ser Val Glu Phe Gln Asn Leu Ala Thr Leu Lys Pro Ser 
             900                905                910
Asn Lys Ala Phe Glu Lys Lys Phe Arg Phe Asp Tyr Thr Asn Glu Arg 
         915                920                925
Ala Leu Arg Arg Thr Leu Gln Glu Asp Leu Val Lys Asp Val Leu Ser 
     930                935                940
Asn Ala His Ile Gln Asn Glu Leu Glu Arg Glu Phe Glu Arg Met Arg 
 945                950                955                960
Glu Asp Arg Glu Val Leu Arg Val Ile Phe Pro Thr Gly Asp Ser Lys 
                 965                970                975
Val Val Leu Pro Cys Asn Leu Leu Arg Met Ile Trp Asn Ala Gln Lys 
             980                985                990
Ile Phe His Ile Asn Pro Arg Leu Pro Ser Asp Leu His Pro Ile Lys 
         995                1000                1005
Val Val Glu Gly Val Lys Glu Leu Ser Lys Lys Leu Val Ile Val Asn 
     1010                1015                1020
Gly Asp Asp Pro Leu Ser Arg Gln Ala Gln Glu Asn Ala Thr Leu Leu 
 1025                1030                1035                1040
Phe Asn Ile His Leu Arg Ser Thr Leu Cys Ser Arg Arg Met Ala Glu 
                 1045                1050                1055
Glu Phe Arg Leu Ser Gly Glu Ala Phe Asp Trp Leu Leu Gly Glu Ile 
             1060                1065                1070
Glu Ser Lys Phe Asn Gln Ala Ile Ala His Pro Gly Glu Met Val Gly 
         1075                1080                1085
Ala Leu Ala Ala Gln Ser Leu Gly Glu Pro Ala Thr Gln Met Thr Leu 
     1090                1095                1100
Asn Thr Phe His Tyr Ala Gly Val Ser Ala Lys Asn Val Thr Leu Gly 
 1105                1110                1115                1120
Val Pro Arg Leu Lys Glu Leu Ile Asn Ile Ser Lys Lys Pro Lys Thr 
                 1125                1130                1135
Pro Ser Leu Thr Val Phe Leu Leu Gly Gln Ser Ala Arg Asp Ala Glu 
             1140                1145                1150
Arg Ala Lys Asp Ile Leu Cys Arg Leu Glu His Thr Thr Leu Arg Lys 
         1155                1160                1165
Val Thr Ala Asn Thr Ala Ile Tyr Tyr Asp Pro Asn Pro Gln Ser Thr 
     1170                1175                1180
Val Val Ala Glu Asp Gln Glu Trp Val Asn Val Tyr Tyr Glu Met Pro 
 1185                1190                1195                1200
Asp Phe Asp Val Ala Arg Ile Ser Pro Trp Leu Leu Arg Val Glu Leu 
                 1205                1210                1215
Asp Arg Lys His Met Thr Asp Arg Lys Leu Thr Met Glu Gln Ile Ala 
             1220                1225                1230
Glu Lys Ile Asn Ala Gly Phe Gly Asp Asp Leu Asn Cys Ile Phe Asn 
         1235                1240                1245
Asp Asp Asn Ala Glu Lys Leu Val Leu Arg Ile Arg Ile Met Asn Ser 
     1250                1255                1260
Asp Glu Asn Lys Met Gln Glu Glu Glu Glu Val Val Asp Lys Met Asp 
 1265                1270                1275                1280
Asp Asp Val Phe Leu Arg Cys Ile Glu Ser Asn Met Leu Thr Asp Met 
                 1285                1290                1295
Thr Leu Gln Gly Ile Glu Gln Ile Ser Lys Val Tyr Met His Leu Pro 
             1300                1305                1310
Gln Thr Asp Asn Lys Lys Lys Ile Ile Ile Thr Glu Asp Gly Glu Phe 
         1315                1320                1325
Lys Ala Leu Gln Glu Trp Ile Leu Glu Thr Asp Gly Val Ser Leu Met 
     1330                1335                1340
Arg Val Leu Ser Glu Lys Asp Val Asp Pro Val Arg Thr Thr Ser Asn 
 1345                1350                1355                1360
Asp Ile Val Glu Ile Phe Thr Val Leu Gly Ile Glu Ala Val Arg Lys 
                 1365                1370                1375
Ala Leu Glu Arg Glu Leu Tyr His Val Ile Ser Phe Asp Gly Ser Tyr 
             1380                1385                1390
Val Asn Tyr Arg His Leu Ala Leu Leu Cys Asp Thr Met Thr Cys Arg 
         1395                1400                1405
Gly His Leu Met Ala Ile Thr Arg His Gly Val Asn Arg Gln Asp Thr 
     1410                1415                1420
Gly Pro Leu Met Lys Cys Ser Phe Glu Glu Thr Val Asp Val Leu Met 
 1425                1430                1435                1440
Glu Ala Ala Ala His Gly Glu Ser Asp Pro Met Lys Gly Val Ser Glu 
                 1445                1450                1455
Asn Ile Met Leu Gly Gln Leu Ala Pro Ala Gly Thr Gly Cys Phe Asp 
             1460                1465                1470
Leu Leu Leu Asp Ala Glu Lys Cys Lys Tyr Gly Met Glu Ile Pro Thr 
         1475                1480                1485
Asn Ile Pro Gly Leu Gly Ala Ala Gly Pro Thr Gly Met Phe Phe Gly 
     1490                1495                1500
Ser Ala Pro Ser Pro Met Gly Gly Ile Ser Pro Ala Met Thr Pro Trp 
 1505                1510                1515                1520
Asn Gln Gly Ala Thr Pro Ala Tyr Gly Ala Trp Ser Pro Ser Val Gly 
                 1525                1530                1535
Ser Gly Met Thr Pro Gly Ala Ala Gly Phe Ser Pro Ser Ala Ala Ser 
             1540                1545                1550
Asp Ala Ser Gly Phe Ser Pro Gly Tyr Ser Pro Ala Trp Ser Pro Thr 
         1555                1560                1565
Pro Gly Ser Pro Gly Ser Pro Gly Pro Ser Ser Pro Tyr Ile Pro Ser 
     1570                1575                1580
Pro Gly Gly Ala Met Ser Pro Ser Tyr Ser Pro Thr Ser Pro Ala Tyr 
 1585                1590                1595                1600
Glu Pro Arg Ser Pro Gly Gly Tyr Thr Pro Gln Ser Pro Ser Tyr Ser 
                 1605                1610                1615
Pro Thr Ser Pro Ser Tyr Ser Pro Thr Ser Pro Ser Tyr Ser Pro Thr 
             1620                1625                1630
Ser Pro Asn Tyr Ser Pro Thr Ser Pro Ser Tyr Ser Pro Thr Ser Pro 
         1635                1640                1645
Ser Tyr Ser Pro Thr Ser Pro Ser Tyr Ser Pro Thr Ser Pro Ser Tyr 
     1650                1655                1660
Ser Pro Thr Ser Pro Ser Tyr Ser Pro Thr Ser Pro Ser Tyr Ser Pro 
 1665                1670                1675                1680
Thr Ser Pro Ser Tyr Ser Pro Thr Ser Pro Ser Tyr Ser Pro Thr Ser 
                 1685                1690                1695
Pro Ser Tyr Ser Pro Thr Ser Pro Ser Tyr Ser Pro Thr Ser Pro Ser 
             1700                1705                1710
Tyr Ser Pro Thr Ser Pro Ser Tyr Ser Pro Thr Ser Pro Ser Tyr Ser 
         1715                1720                1725
Pro Thr Ser Pro Ser Tyr Ser Pro Thr Ser Pro Ser Tyr Ser Pro Thr 
     1730                1735                1740
Ser Pro Asn Tyr Ser Pro Thr Ser Pro Asn Tyr Thr Pro Thr Ser Pro 
 1745                1750                1755                1760
Ser Tyr Ser Pro Thr Ser Pro Ser Tyr Ser Pro Thr Ser Pro Asn Tyr 
                 1765                1770                1775
Thr Pro Thr Ser Pro Asn Tyr Ser Pro Thr Ser Pro Ser Tyr Ser Pro 
             1780                1785                1790
Thr Ser Pro Ser Tyr Ser Pro Thr Ser Pro Ser Tyr Ser Pro Ser Ser 
         1795                1800                1805
Pro Arg Tyr Thr Pro Gln Ser Pro Thr Tyr Thr Pro Ser Ser Pro Ser 
     1810                1815                1820
Tyr Ser Pro Ser Ser Pro Ser Tyr Ser Pro Thr Ser Pro Lys Tyr Thr 
 1825                1830                1835                1840
Pro Thr Ser Pro Ser Tyr Ser Pro Ser Ser Pro Glu Tyr Thr Pro Thr 
                 1845                1850                1855
Ser Pro Lys Tyr Ser Pro Thr Ser Pro Lys Tyr Ser Pro Thr Ser Pro 
             1860                1865                1870
Lys Tyr Ser Pro Thr Ser Pro Thr Tyr Ser Pro Thr Thr Pro Lys Tyr 
         1875                1880                1885
Ser Pro Thr Ser Pro Thr Tyr Ser Pro Thr Ser Pro Val Tyr Thr Pro 
     1890                1895                1900
Thr Ser Pro Lys Tyr Ser Pro Thr Ser Pro Thr Tyr Ser Pro Thr Ser 
 1905                1910                1915                1920
Pro Lys Tyr Ser Pro Thr Ser Pro Thr Tyr Ser Pro Thr Ser Pro Lys 
                 1925                1930                1935
Gly Ser Thr Tyr Ser Pro Thr Ser Pro Gly Tyr Ser Pro Thr Ser Pro 
             1940                1945                1950
Thr Tyr Ser Leu Thr Ser Pro Ala Ile Ser Pro Asp Asp Ser Asp Glu 
         1955                1960                1965
Glu Asn 
     1970



<210> 2967
<211> 494
<212> DNA
<213> Rattus norvegicus
<308> L18948
<400> 2967

cggcacgag  tccttagct  tgagcaaga  gatggctgc  aaaacagga  ctcagctgg  60
gcgcagcat  agcaccatc  tcaatgttt  ccatcagta  tctaggaag  atggacatc  120
tgacaccct  aacaaggcg  aattcaaag  aatggtgaa  aaggacttg  caaattttc  180
gaagaggga  aaaagaaat  aaaatctcc  aagagacat  atggaggac  tggacacaa  240
ccaggacaa  caactgtcc  ttgaggagt  tatgatgct  atgggaaag  tgatctttg  300
ctgtcatga  aagctgcat  agaacaacc  acgtgggca  gaccacagg  acggcaaag  360
ctgtgggaa  taattaaga  gtcgccatg  aacatctgc  caaccaagt  taaagggaa  420
agcttacta  atgaccttg  ttctggggc  gggaaataa  ttaaaaatg  ataaataaa  480
tctttatcc  ttcc  494



<210> 2968
<211> 112
<212> PRT
<213> Rattus norvegicus
<308> P50116
<400> 2968

Ala Ala Lys Thr Gly Ser Gln Leu Glu Arg Ser Ile Ser Thr Ile Ile 
  1               5                  10                  15
Asn Val Phe His Gln Tyr Ser Arg Lys Tyr Gly His Pro Asp Thr Leu 
             20                  25                  30
Asn Lys Ala Glu Phe Lys Glu Met Val Asn Lys Asp Leu Pro Asn Phe 
         35                  40                  45
Leu Lys Arg Glu Lys Arg Asn Glu Asn Leu Leu Arg Asp Ile Met Glu 
     50                  55                  60
Asp Leu Asp Thr Asn Gln Asp Asn Gln Leu Ser Phe Glu Glu Cys Met 
 65                  70                  75                  80
Met Leu Met Gly Lys Leu Ile Phe Ala Cys His Glu Lys Leu His Glu 
                 85                  90                  95
Asn Asn Pro Arg Gly His Asp His Ser His Gly Lys Gly Cys Gly Lys 
             100                105                110



<210> 2969
<211> 462
<212> DNA
<213> Homo sapiens
<308> X06233
<400> 2969

aaaacactc  gtgtggctc  tcggctttg  cagagtgca  gacgatgac  tgcaaaatg  60
cgcagctgg  acgcaacat  gagaccatc  tcaacacct  ccaccaata  tctgtgaag  120
tggggcacc  agacaccct  aaccagggg  aattcaaag  gctggtgcg  aaagatctg  180
aaaattttc  caagaagga  aataagaat  aaaaggtca  agaacacat  atggaggac  240
tggacacaa  tgcagacaa  cagctgagc  tcgaggagt  catcatgct  atggcgagg  300
taacctggg  ctcccacga  aagatgcac  agggtgacg  gggccctgg  caccaccat  360
agccaggcc  cggggaggg  accccctaa  accacagtg  ccaagatca  agtggccac  420
gccacggcc  cagtcatgg  ggccacggc  acagccacc  at  462



<210> 2970
<211> 114
<212> PRT
<213> Homo sapiens
<308> P06702
<400> 2970

Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile 
  1               5                  10                  15
Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu 
             20                  25                  30
Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe 
         35                  40                  45
Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu 
     50                  55                  60
Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile 
 65                  70                  75                  80
Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu 
                 85                  90                  95
Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly 
             100                105                110
Thr Pro 
         115



<210> 2971
<211> 1062
<212> DNA
<213> Rattus norvegicus
<308> L19112
<400> 2971

atatcacaa  tgtgcagat  ggattaacg  ccacatgga  atatggaac  ggaccaggg  60
ttggcaccg  gaccatggt  agctggggg  gcttcatct  cctggtctt  gtcaccatg  120
caaccttgt  cctggcccg  ccctccttc  gtttagttg  agataccac  ttagaacca  180
aagatgcca  ctcatctgg  gatgacgag  acgacacag  tagctccga  gactttgtc  240
gtgagaaca  gagcaacca  agagcaccg  actggacca  caccgaaaa  atggagaag  300
ggctccatg  tgtccctgc  gccaacact  tgaagttcc  ctgtccagc  ggggggaat  360
caacaccca  aatgaggtg  ctaaaaaac  ggaaggagt  taagcagga  catcgcatc  420
gaggctata  ggtacgaaa  cagcactgg  gccttatta  ggaaagtgt  gtcccatca  480
acaaaggca  ttacacctg  ctggtggag  atgaatacg  gtccatcaa  cacacctac  540
accttgatg  tgttgagcg  tcaccacac  ggcccatcc  ccaagctgg  ctgcctgca  600
atgcctcca  ggtggtcgg  ggggacgta  aatttgtct  caaggttta  agtgatgcc  660
agccccata  ccagtggat  aaacatgtg  aaaagaacg  cagtaaata  ggacctgat  720
ggctgccct  cctcaaggt  ctgaaggcc  ccggtgtta  caccacgga  aaagaaatt  780
aggttctct  tattcggaa  gtaactttt  aggatgctg  ggaatatac  tgcttggcg  840
gtaattcta  cgggatatc  tttcactct  catggttga  agttctgcc  gcacctgtg  900
gagagaagg  gatcacagc  tccccagat  acctggaga  agctattta  agcataggg  960
tcttcttaa  cgcctgcat  gtggtgaca  tcatctttt  ccgaatgaa  accacgacc  1020
agaagccag  cttcagcag  cagccggct  tgcacaagc  ga  1062



<210> 2972
<211> 1475
<212> DNA
<213> Homo sapiens
<308> U11814
<400> 2972

tcttctgcg  ttggagttg  tccccgcaa  cccgggctc  tcgctttct  catcccgac  60
cacgcgggg  cggggacaa  acaggtcgc  gaggagcgt  gccattcaa  tgactgcag  120
agcagcgca  cgcctcggt  cctgagccc  ccgcagctg  aggcattgc  cgtagtcca  180
gcccgtaga  gaagtgtgc  gatgggatt  acgtccaca  ggagatatg  aagaggacc  240
gggattggt  ccgtaacca  ggtcagctg  ggtcgtttc  tctgcctgg  cgtggtcac  300
atggcaacc  tgtccctgg  ccggccctc  ttcagttta  ttgaggata  cacattaga  360
ccagaagag  caccaacca  ataccaaat  tctcaacca  aagtgtacg  ggctgcgcc  420
ggggagtcg  tagaggtgc  ctgcctgtt  aaagatgcc  ccgtgatca  ttggactaa  480
gatggggtg  acttggggc  caacaatag  acagtgctt  ttggggagt  cttgcagat  540
aagggcgcc  cacctagag  ctccggcct  tatgcttgt  ctgccagta  gactgtaga  600
agtgaaact  ggtacttca  ggtgaatgt  acagatgcc  tctcatccg  agatgatga  660
gatgacacc  atggtgcgg  agattttgt  agtgagaac  gtaacaaca  gagagcacc  720
tactggacc  acacagaaa  gatggaaaa  cggctccat  ctgtgcctg  ggccaacac  780
gtcaagttt  gctgcccag  cggggggaa  ccaatgcca  ccatgcggt  gctgaaaaa  840
gggaaggag  ttaagcagg  gcatcgcat  ggaggctac  aggtacgaa  ccagcactg  900
agcctcatt  tggaaagtg  ggtcccatc  gacaaggga  attatacct  tgtagtgga  960
aatgaatac  ggtccatca  tcacacgta  cacctggat  ttgtggagc  atcgcctca  1020
cggcccatc  tccaagccg  actgccggc  aatgcctcc  cagtggtcg  aggagacgt  1080
gagtttgtc  gcaaggttt  cagtgatgc  cagccccac  tccagtgga  caagcacgt  1140
gaaaagaac  gcagtaaat  cgggcccga  gggctgccc  acctcaagg  tctcaagca  1200
tcggggata  atagttcca  tgcagaagt  ctggctctg  tcaatgtga  cgaggcgga  1260
gctggggaa  atatatgta  ggtctccaa  tatataggg  aggccaacc  gtctgcctg  1320
ctcactgtc  tgccaaaac  gcaaggccg  cggtgttaa  accacggac  aagagattg  1380
ggttctcta  attcggaat  taacttttg  ggacgctgg  gaatatacg  gcttggcgg  1440
taattctat  gggatatcc  ttcactctg  atggt  1475



<210> 2973
<211> 821
<212> PRT
<213> Homo sapiens
<308> P21802
<400> 2973

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
  1               5                  10                  15
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
             20                  25                  30
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
         35                  40                  45
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
     50                  55                  60
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
 65                  70                  75                  80
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                 85                  90                  95
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
             100                105                110
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
         115                120                125
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
     130                135                140
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
 145                150                155                160
Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                 165                170                175
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
             180                185                190
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
         195                200                205
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
     210                215                220
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
 225                230                235                240
Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                 245                250                255
Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
             260                265                270
Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
         275                280                285
Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
     290                295                300
Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
 305                310                315                320
Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                 325                330                335
Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
             340                345                350
His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu 
         355                360                365
Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
     370                375                380
Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
 385                390                395                400
Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                 405                410                415
Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
             420                425                430
Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
         435                440                445
Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
     450                455                460
Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
 465                470                475                480
Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                 485                490                495
Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
             500                505                510
Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
         515                520                525
Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
     530                535                540
Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
 545                550                555                560
Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                 565                570                575
Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
             580                585                590
Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
         595                600                605
Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
     610                615                620
Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
 625                630                635                640
Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                 645                650                655
Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
             660                665                670
Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
         675                680                685
Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
     690                695                700
Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
 705                710                715                720
Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                 725                730                735
Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
             740                745                750
Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
         755                760                765
Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
     770                775                780
Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
 785                790                795                800
Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                 805                810                815
Gly Ser Val Lys Thr 
             820



<210> 2974
<211> 5412
<212> DNA
<213> Rattus norvegicus
<308> L19180
<400> 2974

cagggcgga  gctggaggc  actgccaag  atggcgccc  cctggagac  cagcgtggt  60
tctgtggtg  gtcctgtgg  gctcttcct  gtactgctg  ccagagggt  cttggctga  120
gagccaccc  gatttatca  agagcccaa  gatcagatt  gtgtgtcag  aggcgtggc  180
tccttcgtg  gccaggcca  aggtgaccc  aagccacgg  tgacctgga  caagaaggg  240
aagaaagtg  actcacagc  ctttgagac  attgacttt  acgagagct  gggggccgt  300
ctgaggatc  agccacttc  gacaccccg  gatgagaac  tgtacgagt  tgtggccca  360
aactcggtg  gggagatca  agttcatgc  aagctcacc  tcctgcgag  ggaccagct  420
cctcctggc  tccccaaca  tgacatggg  ccccagttg  aggttgtag  gcgcacacg  480
acagccacc  tgctctgtg  tgccagcgg  aaccctgac  ctgagatca  ctggttcaa  540
gacttcctg  ctgtggacc  cagtgccag  aatgggcgg  tcaagcagc  tcggtcagg  600
gccctgcag  ttgagagca  cgaggagac  gaccagggc  agtacgagt  tgtggccac  660
aaacaggcg  gggtgcgct  ctcatcacc  gccaacctc  acgtgcgag  ccgccgtgt  720
gccccccgc  tctccatcc  gcccatgag  cacgagatc  tgcccggtg  gaatgtgaa  780
atcacttgt  tggctgtgg  ctcacccat  ccctacgtg  agtggatgc  gggggcaga  840
gacctgacg  ctgaggatg  catgcccgt  ggtcggaat  tcctcgaac  cacggatgt  900
aaagactca  ccaactatc  ttgtgtggc  atgtccagc  tgggagtga  cgaggccgt  960
gctgacatc  ctgtaaaat  tctccccaa  gcccctggg  ctcccgtgg  gacggagaa  1020
actgctacc  gtatcactg  cacatggga  gcaggcaat  ctgaccctg  gtcctacta  1080
gtattgagt  taatcaaag  caggatggg  cgtatcaga  caaagaaga  atcaaccac  1140
acgcgctac  gcatcggcg  cctgagccc  aactctgag  atgagatct  ggtgtcagc  1200
gtcaactcc  tcggccagg  ccccagtga  tcggtggtg  cccgcacag  cgagcaggc  1260
ccagccagt  ctcccagga  tgttcaggc  cgcatgctc  gtgccacca  catgattgt  1320
cagtgggag  agcccgtgg  gcccaatgg  ctgatccgt  gctaccgcg  ctactacac  1380
atggagccc  agcatccgg  gggcaactg  cagaagcac  atgtggacg  cagtcttct  1440
accactgtg  gcagcctgc  agaggatga  acctacact  tgagagtgc  cgccttcac  1500
tcggtgggc  atgggccac  gtcagaccc  atccaggtc  agacccagc  gggagtgcc  1560
ggccagccc  tgaacttgc  ggctgaggc  aagtcagag  ccagcattg  gctctcgtg  1620
agtgcacca  ggcaggaga  tgtcattaa  tatgaactg  tcttccggg  gggcgaccg  1680
ggccgagag  tggggcgaa  cttcgaccc  accacagcc  ttgtggtgg  ggacctcaa  1740
cccaatacg  agtacgcgt  ccggctggc  gctcgctcg  cgcagggcc  gggcgcctt  1800
accgcggtt  tgcgccagc  cacactgca  gccatctcc  ccaagaact  caaggtgaa  1860
atgatcatg  aaacttcag  gctgctaag  tgggagttc  ctgacaact  taactcacc  1920
acgccctac  agatccagt  caatggact  acactggac  tggatggcc  cactaccaa  1980
aagctgatc  cgcacctca  gccacacac  ttctataac  tcgtgctca  caaccgtgg  2040
agcagcctg  gaggcctgc  gcagacggt  accgccagg  ccgccttca  catgctcag  2100
ggcaagcct  gtgtcgccc  aaagcctga  aacgatggt  ccattgtgg  ctacctgcc  2160
gatggccag  gtcccgtga  agtgcagaa  tacttcatt  tgatggtcc  acttcggaa  2220
tctcgtggt  gccagttcc  tatcctact  cctagtcca  aggacatgg  tctggagga  2280
ctcatccag  acctctccc  gctgcagag  agcctgcgc  actcaagac  gctggaggt  2340
cctcggcct  acatcgccg  tcggttctc  atcctgcca  ctgtcttcc  tcctgggaa  2400
cagaagcaa  atggtggct  tgacaacag  ggcttggag  caggccacc  ttatgtcct  2460
tttgtactt  ctgtgctgc  gaagaatga  cctacattt  cagccagtc  cttctcaga  2520
cccttccaa  tggacaacc  agacccgca  cccattgtg  atggcgagg  gggcctcat  2580
tgggtgatc  ggcccgtgc  ggccgtggt  ttcatcatc  gcatcgtaa  tgccatcct  2640
ctgtacaag  acaagcctg  cagcaaacg  aaggactca  agccccgca  caaatgctt  2700
ttgaacaat  cagacctcg  cccccatca  cccaaggac  ctgtggaaa  gcgacgtat  2760
aacttccag  cgccaggta  gctcagcca  ccgcccatt  ccatcacag  catggctga  2820
cacatggag  gactcaaag  caacgacag  ctcaagctc  cccaggagt  tgagtccat  2880
gaccctggc  agcagttca  ttgggaaca  tcgaacctg  aggccaaca  gccaaagaa  2940
cgatacgcc  atgtcatcg  ctatgacca  tcacgagtc  tcctgcagc  tttagaagg  3000
atcatgggt  gtgattaca  caatgccaa  tatgttgac  gctatcggc  gcagaacgc  3060
tacatcgcc  cgcaggggc  cctgcctga  acctttggg  acttctggc  gatggtgtg  3120
gagcagcgg  cagccactg  ggtcatgat  acacggctg  aggagaaat  acgggtcaa  3180
tgtgaccag  actggccta  ccgaggcac  gagacatac  gcttcatcc  ggtcaccct  3240
ctagatact  tggagctgg  caccttctg  gtcaggacc  tttctctac  caagaatgg  3300
tctagtgag  agcgtgagg  acgacattt  cagttcaca  catggcctg  ccacggggt  3360
cccgagtac  ccacaccct  cctggcgtt  ctgcgcaga  tcaagacct  caacccgcc  3420
gacgctggc  cagttgtgg  ccactgcag  gcgggtgtg  ggcgtactg  ctgcttcat  3480
gtaattgat  ccatgttgg  gcgcatcag  acagagaag  cggtggatg  gtacggaca  3540
gtgacactc  tgcggtcac  gcgcaacta  atggtgcag  cagaggatc  gtatagctt  3600
atccacgag  cactgctgg  ggctgtggg  tgtggcaat  ccgaggtcc  cgcgcgcag  3660
ctctacacc  atatccaga  gctggccca  gtggagcct  gcgagcatg  cacaggaat  3720
gagcttgag  tcaagaggc  tgcagctcc  aggcacaca  ttcgagatt  attcactgc  3780
agcctgcct  gcaacaagt  taagaaccg  ctggtgaac  tcctgccgt  cgagagctc  3840
cgtgtctgc  tgcagccca  tcgtggtgt  gagggctct  actacatca  tgccagctt  3900
atcgacggc  acagacagc  gaaagccta  attgcaacg  agggtccac  ggcagagac  3960
acagaggac  tctggcgtg  cctgtggga  aacaactcc  ctattgtgg  aatgctcac  4020
aagctccgc  agatgggcc  ggagaagtg  caccagtac  ggccagctg  gcgctctgc  4080
cgctaccag  actttgtgg  tgacccgat  gcagagtat  acatgccag  gtacattct  4140
cgtgagttt  aggtcacag  tgcccggga  ggccagtcc  ggaccgtcc  acagttcac  4200
gactggcca  agcagggtg  acccaagtc  ggggaaggc  tcattgact  catcggcca  4260
gtgcataag  ccaaggagc  gtttggcca  gatggcccc  tctcggtgc  ctgtagtgc  4320
ggagtgggc  ggaccggag  attcatcac  ctgagcatc  tgctggagc  aatgcgcta  4380
gagggggtg  tggacattt  ccagacagt  aaggtgctt  ggacccagc  gcctgccat  4440
gtgcagaca  aggatgagt  ccagttctg  ttccaggcg  cgttggaat  gggcagctt  4500
gatcattat  caacataag  catgggccc  gcaacgcct  gacccagct  caagtgccc  4560
gcatgtgag  ccagccctc  gtgctggtg  gaggcggcc  agggaggaa  cctcctctc  4620
ctggagaca  cactgcctt  taagggcac  ttcctcatt  cttctgact  caaaacgag  4680
ttccagggt  gggggtagg  tggagagta  aggagccac  gctcccata  ctggggtca  4740
aagggacag  actctgctc  cacacttcc  tgcctgcct  cctgtcagc  acattcttt  4800
ttttcattt  tttaactgt  gtgtatttt  cttcatctt  ttttttttt  taagaaaaa  4860
aaaacaatg  gcagtcaaa  tttgaaaac  acgagacac  ttggctctg  ttgtcgctc  4920
gtggagggc  aacttttca  agtaagtgt  tcgtgtggc  gctctgtgc  acaactttg  4980
tggcttctg  gtgcattct  cccacatgt  cccgtgtga  tggctcacg  aggttttct  5040
tttaccctt  ttacttttt  tttaaatca  tcttcagac  tatcagatg  gaaggggtg  5100
tggctggag  acctgggcc  ggctgcagg  catggccac  aggacacag  ggctggcct  5160
actgcccag  ccctgccgc  ccagagagg  tctttgtcc  ctcctgact  atgccccgc  5220
tggaggacc  ccgggacta  ggacacttg  ggacacgca  ccccctaga  caagtgagg  5280
ctctctttg  aggagagtg  gtcagcact  gtccccgct  gttttttgg  cagaagcgg  5340
tgacagccc  gtatgtaga  aaaccaagt  tgtattaat  aagattcgt  cgacctaaa  5400
aaaaaaaaa  aa  5412



<210> 2975
<211> 1496
<212> PRT
<213> Rattus norvegicus
<308> L19180
<400> 2975

Met Ala Pro Thr Trp Arg Pro Ser Val Val Ser Val Val Gly Pro Val 
  1               5                  10                  15
Gly Leu Phe Leu Val Leu Leu Ala Arg Gly Cys Leu Ala Glu Glu Pro 
             20                  25                  30
Pro Arg Phe Ile Arg Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly 
         35                  40                  45
Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val 
     50                  55                  60
Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr 
 65                  70                  75                  80
Ile Asp Phe Asp Glu Ser Ser Gly Ala Val Leu Arg Ile Gln Pro Leu 
                 85                  90                  95
Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser 
             100                105                110
Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp 
         115                120                125
Gln Leu Pro Pro Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys 
     130                135                140
Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly 
 145                150                155                160
Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp 
                 165                170                175
Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Gly Ala Leu 
             180                185                190
Gln Ile Glu Ser Ser Glu Glu Thr Asp Gln Gly Lys Tyr Glu Cys Val 
         195                200                205
Ala Thr Lys Gln Ala Gly Val Arg Tyr Ser Ser Pro Ala Asn Leu Tyr 
     210                215                220
Val Arg Val Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser 
 225                230                235                240
His Glu Ile Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val 
                 245                250                255
Gly Ser Pro Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu 
             260                265                270
Thr Pro Glu Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr 
         275                280                285
Asp Val Lys Asp Ser Ala Asn Tyr Pro Cys Val Ala Met Ser Ser Leu 
     290                295                300
Gly Val Ile Glu Ala Val Ala Asp Ile Thr Val Lys Ser Leu Pro Lys 
 305                310                315                320
Ala Pro Gly Thr Pro Val Val Thr Glu Asn Thr Ala Thr Ser Ile Thr 
                 325                330                335
Val Thr Trp Asp Ala Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Leu 
             340                345                350
Ser Ile Ile Lys Ala Arg Met Gly Arg Ile Arg Ser Lys Lys Thr Ser 
         355                360                365
Thr Thr Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu Tyr 
     370                375                380
Glu Ile Trp Val Ser Ala Val Asn Ser Ile Gly Gln Ala Pro Ser Glu 
 385                390                395                400
Ser Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala Pro Arg 
                 405                410                415
Asn Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val Gln Trp 
             420                425                430
Glu Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg Val Tyr 
         435                440                445
Tyr Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys His Asn 
     450                455                460
Val Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu Asp Glu 
 465                470                475                480
Thr Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp Gly Pro 
                 485                490                495
Leu Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro Gly Gln 
             500                505                510
Pro Met Asn Leu Arg Ala Glu Ala Lys Ser Glu Thr Ser Ile Gly Leu 
         515                520                525
Ser Trp Ser Ala Pro Arg Gln Glu Ser Val Ile Lys Tyr Glu Leu Leu 
     530                535                540
Phe Arg Glu Gly Asp Arg Gly Arg Glu Val Gly Arg Thr Phe Asp Pro 
 545                550                555                560
Thr Thr Ala Phe Val Val Glu Asp Leu Lys Pro Asn Thr Glu Tyr Ala 
                 565                570                575
Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe Thr Ala 
             580                585                590
Val Val Arg Gln Arg Thr Leu Gln Ala Ile Ser Pro Lys Asn Phe Lys 
         595                600                605
Val Lys Met Ile Met Lys Thr Ser Val Leu Leu Ser Trp Glu Phe Pro 
     610                615                620
Asp Asn Tyr Asn Ser Pro Thr Pro Tyr Lys Ile Gln Tyr Asn Gly Leu 
 625                630                635                640
Thr Leu Asp Val Asp Gly Arg Thr Thr Lys Lys Leu Ile Thr His Leu 
                 645                650                655
Lys Pro His Thr Phe Tyr Asn Phe Val Leu Thr Asn Arg Gly Ser Ser 
             660                665                670
Leu Gly Gly Leu Gln Gln Thr Val Thr Ala Arg Thr Ala Phe Asn Met 
         675                680                685
Leu Ser Gly Lys Pro Ser Val Ala Pro Lys Pro Asp Asn Asp Gly Ser 
     690                695                700
Ile Val Val Tyr Leu Pro Asp Gly Gln Ser Pro Val Thr Val Gln Asn 
 705                710                715                720
Tyr Phe Ile Val Met Val Pro Leu Arg Lys Ser Arg Gly Gly Gln Phe 
                 725                730                735
Pro Ile Leu Leu Pro Ser Pro Glu Asp Met Asp Leu Glu Glu Leu Ile 
             740                745                750
Gln Asp Leu Ser Arg Leu Gln Ser Ser Leu Arg His Ser Arg Gln Leu 
         755                760                765
Glu Val Pro Arg Pro Tyr Ile Ala Ala Arg Phe Ser Ile Leu Pro Ala 
     770                775                780
Val Phe His Pro Gly Asn Gln Lys Gln Tyr Gly Gly Phe Asp Asn Arg 
 785                790                795                800
Gly Leu Glu Pro Gly His Arg Tyr Val Leu Phe Val Leu Ala Val Leu 
                 805                810                815
Gln Lys Asn Glu Pro Thr Phe Ala Ala Ser Pro Phe Ser Asp Pro Phe 
             820                825                830
Gln Leu Asp Asn Pro Asp Pro Gln Pro Ile Val Asp Gly Glu Glu Gly 
         835                840                845
Leu Ile Trp Val Ile Gly Pro Val Leu Ala Val Val Phe Ile Ile Cys 
     850                855                860
Ile Val Ile Ala Ile Leu Leu Tyr Lys Asn Lys Pro Asp Ser Lys Arg 
 865                870                875                880
Lys Asp Ser Glu Pro Arg Thr Lys Cys Leu Leu Asn Asn Ala Asp Leu 
                 885                890                895
Ala Pro His His Pro Lys Asp Pro Val Glu Met Arg Arg Ile Asn Phe 
             900                905                910
Gln Thr Pro Gly Met Leu Ser His Pro Pro Ile Pro Ile Thr Asp Met 
         915                920                925
Ala Glu His Met Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser 
     930                935                940
Gln Glu Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr Trp Glu His 
 945                950                955                960
Ser Asn Leu Glu Ala Asn Lys Pro Lys Asn Arg Tyr Ala Asn Val Ile 
                 965                970                975
Ala Tyr Asp His Ser Arg Val Ile Leu Gln Pro Leu Glu Gly Ile Met 
             980                985                990
Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr Arg Arg Gln 
         995                1000                1005
Asn Ala Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Phe Gly Asp 
     1010                1015                1020
Phe Trp Arg Met Val Trp Glu Gln Arg Ser Ala Thr Val Val Met Met 
 1025                1030                1035                1040
Thr Arg Leu Glu Glu Lys Ser Arg Val Lys Cys Asp Gln Tyr Trp Pro 
                 1045                1050                1055
Asn Arg Gly Thr Glu Thr Tyr Gly Phe Ile Gln Val Thr Leu Leu Asp 
             1060                1065                1070
Thr Met Glu Leu Ala Thr Phe Cys Val Arg Thr Phe Ser Leu His Lys 
         1075                1080                1085
Asn Gly Ser Ser Glu Lys Arg Glu Val Arg His Phe Gln Phe Thr Ala 
     1090                1095                1100
Trp Pro Asp His Gly Val Pro Glu Tyr Pro Thr Pro Phe Leu Ala Phe 
 1105                1110                1115                1120
Leu Arg Arg Val Lys Thr Cys Asn Pro Pro Asp Ala Gly Pro Val Val 
                 1125                1130                1135
Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Cys Phe Ile Val Ile 
             1140                1145                1150
Asp Ala Met Leu Glu Arg Ile Arg Thr Glu Lys Thr Val Asp Val Tyr 
         1155                1160                1165
Gly His Val Thr Leu Met Arg Ser Gln Arg Asn Tyr Met Val Gln Thr 
     1170                1175                1180
Glu Asp Gln Tyr Ser Phe Ile His Glu Ala Leu Leu Glu Ala Val Gly 
 1185                1190                1195                1200
Cys Gly Asn Thr Glu Val Pro Ala Arg Ser Leu Tyr Thr Tyr Ile Gln 
                 1205                1210                1215
Lys Leu Ala Gln Val Glu Pro Gly Glu His Val Thr Gly Met Glu Leu 
             1220                1225                1230
Glu Phe Lys Arg Leu Ala Ala Pro Arg His Thr Leu Arg Asp Ser Phe 
         1235                1240                1245
Thr Ala Ser Leu Pro Cys Asn Lys Phe Lys Asn Arg Leu Val Asn Ile 
     1250                1255                1260
Leu Pro Tyr Glu Ser Ser Arg Val Cys Leu Gln Pro Ile Arg Gly Val 
 1265                1270                1275                1280
Glu Gly Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln 
                 1285                1290                1295
Gln Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ala Glu Thr Thr Glu 
             1300                1305                1310
Asp Phe Trp Arg Ala Leu Trp Glu Asn Asn Ser Thr Ile Val Val Met 
         1315                1320                1325
Leu Thr Lys Leu Arg Glu Met Gly Arg Glu Lys Cys His Gln Tyr Trp 
     1330                1335                1340
Pro Ala Glu Arg Ser Ala Arg Tyr Gln Tyr Phe Val Val Asp Pro Met 
 1345                1350                1355                1360
Ala Glu Tyr Asn Met Pro Glu Tyr Ile Leu Arg Glu Phe Lys Val Thr 
                 1365                1370                1375
Asp Ala Arg Asp Gly Gln Ser Arg Thr Val Arg Gln Phe Thr Asp Trp 
             1380                1385                1390
Pro Glu Gln Gly Ala Pro Lys Ser Gly Glu Gly Phe Ile Asp Phe Ile 
         1395                1400                1405
Gly Gln Val His Lys Thr Lys Glu Gln Phe Gly Gln Asp Gly Pro Ile 
     1410                1415                1420
Ser Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Val Phe Ile Thr 
 1425                1430                1435                1440
Leu Ser Ile Val Leu Glu Arg Met Arg Tyr Glu Gly Val Val Asp Ile 
                 1445                1450                1455
Phe Gln Thr Val Lys Val Leu Arg Thr Gln Arg Pro Ala Met Val Gln 
             1460                1465                1470
Thr Glu Asp Glu Tyr Gln Phe Cys Phe Gln Ala Ala Leu Glu Leu Gly 
         1475                1480                1485
Ser Phe Asp His Tyr Ala Thr Ter 
     1490                1495



<210> 2976
<211> 6363
<212> DNA
<213> Homo sapiens
<308> U35234
<400> 2976

cggccagcc  ccagacgtt  ccccatctg  cgctcggct  gaggcctct  tgtgaggga  60
cggggggcc  tccccctcc  gggcggaga  cggaggtcg  tgccaagca  ggcgcccac  120
tggggccct  gcatggtgt  tgtggttgg  cccatgggc  tccttgtgg  cctgctcgt  180
ggaggctgt  cagcagaag  gccccccag  tttatcaaa  aacccaagg  ccagatcgg  240
gtgtcgggg  gtgtggcct  tttcgtgtg  caggccacg  gtgacccca  gccacgagt  300
acctggaac  agaagggca  gaaggtcaa  tctcagcgc  ttgagacga  tgagtttga  360
gagagtgcc  gggcagtgc  gaggatcca  ccgctgagg  caccgcggg  tgaaaacgt  420
tacgagtgt  tggcccaga  ctcggttgg  gagatcaca  tccatgcca  gcttactgt  480
ctccgagag  accagctgc  ctctggctt  cccaacatc  acatgggcc  acagttgaa  540
gtggtggag  ggacacgga  agccaccat  ctctgtgca  ccagcggca  ccctgaccc  600
gagatcacc  ggttcaagg  cttcctgcc  gtggatcct  gtgccagca  tggacgcat  660
aaacagctg  gatcagaaa  ctttgaaag  actccgatt  gaggagccc  gcagattga  720
agcagtgag  aaaccgacc  gggcaaata  gagtgtgtg  ccaccaaca  cgccggcgt  780
cgctactcc  cacctgcca  cctctacgt  cgagagctt  gagaagtcc  ccgcgtggc  840
ccgcgcttc  ccatcctgc  catgagcca  gagatcatg  cagggggca  cgtgaacat  900
acctgcgtg  ccgtgggct  gcccatgcc  tacgtgaag  ggatgcagg  ggccgagga  960
ctgaccccc  aggatgaca  gcccgtggg  cggaacgtg  tggaactca  agatgtcaa  1020
gactcggcc  actacacct  cgtggccat  tccagcctg  gcgtcattg  ggcggttgc  1080
cagatcacg  tgaaatctc  ccccaaagc  cccgggact  ccatggtga  tgagaacac  1140
gccaccagc  tcaccatca  gtgggactc  ggcaaccca  atcctgtgt  ctattacgt  1200
atcgaatat  aatccaaga  ccaagacgg  ccgtatcag  ttaaagagg  catcaccac  1260
acacgttac  gcatcggcg  cctgagccc  aactcggag  acgagatct  ggtgtcggc  1320
gtcaactcc  tcggccagg  gccccccag  gagtccgtg  tcacccgca  aggcgagca  1380
gccccggcc  gcgcgccgc  gaacgtgca  gcccggatg  tcagcgcga  caccatgat  1440
gtgcagtgg  aggagccgg  ggagcccaa  ggcctgatc  gcggctacc  cgtctacta  1500
accatggaa  cggagcacc  cgtgggcaa  tggcagaag  acaacgtgg  cgacagcct  1560
ctgaccacc  tgggcagcc  gctggagga  gagacctac  ccgtgcggg  gctcgcctt  1620
acctccgtc  gcgacgggc  cctctcgga  cccatccag  tcaagacgc  gcagggagt  1680
ccgggccag  ccatgaacc  gcgggccga  gccaggtcg  agaccagca  cacgctgtc  1740
tggagcccc  cgcggcagg  gagtatcat  aagtacgag  tcctcttcc  ggaaggcga  1800
catggccgg  aggtgggaa  gaccttcga  ccgacgact  cctacgtgg  ggaggacct  1860
aagcccaac  cggagtacg  cttccgcct  gccgcccgc  cgccgcagg  cctgggcgc  1920
ttcaccccc  tggtgcggc  gcgcacgct  cagtccaaa  cgtcagccc  ccctcaaga  1980
gttaaatgt  tcagcgtgc  ctccacggc  attttggta  gttggcgcc  gccgccgcc  2040
gaaacgcac  acggggccc  ggtgggcta  agcgtccgc  accgaccgc  gggctcaga  2100
gacccggaa  ccaaggagg  gaacggcat  cccccgacc  ccactcaga  cctgctgga  2160
gccttggag  agtggaccc  gtaccgcat  acgactgtc  ctcacacag  ggtgggacc  2220
gggcccgag  gctcacccg  ggtcgtccg  accgacgag  atgtgccca  cgcgccgcc  2280
cggaaggtg  aggcggagg  gctcaacgc  acggccatc  gcgtgctgt  gctcggccc  2340
gtgcccggc  ggcagcacg  ccagatccg  ggctaccag  tccactacg  gcgcatgga  2400
ggcgccgag  gccgcgggc  gccgcgcat  aaggacgtc  tgctggccg  tgcccagtg  2460
gagacggat  acacggccg  atatgagat  gtcatcaca  acttgcagc  tgagaccgc  2520
tactccatc  cggtagccg  ctacaccat  aagggcgat  gcgctcgca  caaacccaa  2580
gtggttgtg  ccaagggag  agtgttggg  cgcccaacc  tgtcggtgc  gcagacccc  2640
gagggcagc  tgctggcac  ctgggagcc  ccggctggc  ccgcggagg  ccaggtgct  2700
ggctaccgc  tgcagtttg  ccgtgagga  tcgacgccc  tggccaccc  ggagttccc  2760
ccctccgag  accgctaca  ggcatcagg  gtgcacaag  gggccacgt  tgtgttccg  2820
cttgcggcc  ggagccggg  cggcctggg  gaggaggca  ccgaggtcc  gagcatccc  2880
gaggacacg  cccgtggcc  cccgcagat  ttggaagcc  ccggcaacg  ctcggccgg  2940
accgtcctt  tccgctggc  gccacccgt  cccgccgag  gcaacgggg  catcgtcaa  3000
tacacggtg  ccgtgcgtg  ggccggtgc  ctgggccct  cccgagaga  tgagctgcc  3060
gcagcggct  agccgggcg  ggagaacgc  gtcacgctg  agggcctga  gcccgacac  3120
gcctatgac  tccaagtgc  agcccacac  cgccggggc  ctggcccct  cagcccccc  3180
gtccgctac  ggacgttcc  gcgggacca  gtctcgccc  agaacttca  ggtgaaaat  3240
atcatgaag  catcagttc  gctcagctg  gagttccct  acaactaca  ctcacccac  3300
ccctacaag  tccagtaca  tgggctcac  ctggatgtg  atggccgta  caccaagaa  3360
ctcatcacg  acctcaagc  ccacacctt  tacaacttt  tgctgacca  tcgcggcag  3420
agcctgggc  gcctccagc  gacggtcac  gcctggact  ccttcaacc  gctcaacgg  3480
aagcccagc  tcgccccca  gcctgatgc  gacggcttc  tcatggtgt  tcttcctga  3540
ggccagagc  ccgtgcctg  ccagagcta  ttcattgtg  tggtgccac  gcgcaagtc  3600
cgtggaggc  aattcctga  cccgctggg  agcccagag  acatggatc  ggaagagct  3660
atccaggac  tctcacggc  acagaggcg  accgtgcgg  actcgcgtc  gctggaggt  3720
ccccggccc  atattgcag  tcgcttctc  gtgctgcca  ccacgttcc  tcccggcga  3780
cagaagcag  atggcggct  cgataaccg  ggcctggag  ccggccacc  ctatgtcct  3840
ttcgtgctt  ccgtgcttc  gaagagcga  cctaccttt  cagccagtc  cttctcaga  3900
cccttccag  tggataacc  ggaccccca  cccatcgtg  atggcgagg  ggggcttat  3960
tgggtgatc  ggcctgtgc  ggccgtggt  ttcataatc  gcattgtca  tgctatcct  4020
ctctacaag  acaaacccg  cagtaaacg  aaggactca  aaccccgca  caaatgcct  4080
ctgaacaat  ccgacctcg  ccctcacca  cccaaggac  ctgtggaaa  gagacgcat  4140
aacttccag  ctccagatt  aggcctcag  agccccctc  gggagccgg  gtttcactt  4200
gaaagcatg  ttagccacc  gccaattcc  atcgcagac  tggcggagc  cacggagcg  4260
ctcaaggcc  acgacagcc  caagctctc  caggagtat  agtccatcg  ccctggaca  4320
cagttcaca  gggaacatt  caacctgga  gtgaacaag  cgaagaacc  ctatgccaa  4380
gtcatcgcc  atgaccact  ccgtgtcat  ctccagccc  ttgaaggca  catgggcag  4440
gattacatc  atgccaact  tgtggacgg  taccggcgt  agaacgcgt  cattgccac  4500
caggggccg  tgcctgaga  ctttgggga  ttctggcgt  tggtgtggg  gcagcggtc  4560
gcgaccatc  tcatgatga  gcggctgga  gagaagtca  ggatcaagt  tgatcagta  4620
tggcccaac  gaggcacgg  gacctacgg  ttcatccag  tcacgttgc  agataccat  4680
gagctggcc  cattctgcg  caggacatt  tctctgcac  agaatggct  cagtgagaa  4740
cgcgaggtc  gccagttcc  gtttacggc  tggccggac  atggcgtgc  cgaataccc  4800
acgcccttc  tggctttcc  gcggagagt  aagacctgc  acccgccag  tgccggccc  4860
atcgtggtt  actgcagtg  cggtgtggg  cgcacaggc  gctttatcg  catcgacgc  4920
atgcttgag  ggatcaagc  agagaagac  gtcgatgtc  atggccacg  gacgctcat  4980
aggtcccag  gcaactaca  ggtgcagac  gaggaccag  acagcttca  ccacgaggc  5040
ctgctggag  ccgtgggct  tggcaacac  gaagtgccc  cacgcagcc  ctatgccta  5100
atccagaag  tggcccagg  ggagcctgg  gaacacgtc  ctggcatgg  actcgagtt  5160
aagcggctg  ctaactcca  ggcccacac  tcacgcttc  tcagtgcca  tctgccttg  5220
aacaagttc  agaaccgcc  ggtgaacat  atgccctat  agagcacac  ggtctgtct  5280
caacccatc  ggggtgtgg  gggctctga  tacatcaac  ccagcttca  tgatggcta  5340
aggcagcag  aggcctaca  cgcgacaca  gggccgctg  cggagacca  ggaagactt  5400
tggcgcatg  tgtgggaga  caattcgac  atcgtggtg  tgctgacca  gctgcggga  5460
atgggccgg  agaagtgtc  ccagtactg  ccggccgag  gctctgccc  ctaccagta  5520
tttgtggta  atccgatgg  agaatacaa  atgcctcag  atatcctgc  agagttcaa  5580
gtcacagat  cccgggatg  ccagtcccg  actgtccgg  agttccagt  cacagactg  5640
ccggaacag  gtgtgccaa  gtcggggga  ggcttcatc  acttcattg  ccaagtgca  5700
aagactaag  agcagtttg  ccaggacgg  cccatctct  tccactgca  tgccggcgt  5760
ggcaggacg  gcgtcttca  cacgcttag  atcgtgctg  agcggatgc  gtatgaagg  5820
gtggtggac  tctttcaga  ggtgaagat  ctacgaacc  agcggccgg  catggtgca  5880
acagaggat  agtaccagt  ctgttacca  gcggcactg  agtacctcg  aagctttga  5940
cactatgca  cctaaagcc  tggtccccc  caggcccga  accactggc  ccggatgcc  6000
ctgcccctc  cgggcggac  tcctgaggc  tggaccccc  gtgggcagg  caggaggtg  6060
cagcggcag  agctgtgtt  ttctgcacc  tttccgagg  cgacgcatc  cctcgagcc  6120
ccccaccgg  cccggccgc  ccagcgacc  ccctggcac  ggccgccgc  ttcaaatac  6180
tggcacatt  ctcctttcc  tccaattcc  aaaccagat  ccggggtgg  gggtggggg  6240
atggtgagc  aataggagt  ctccccaga  ccagaggag  gtggggcac  gaccataga  6300
ggacccctc  tcctccccc  gcggtggta  ggggacccg  ggggctcct  cccgctctg  6360
acc  6363



<210> 2977
<211> 1949
<212> PRT
<213> Homo sapiens
<308> U35234
<400> 2977

Met Ala Pro Thr Trp Gly Pro Gly Met Val Ser Val Val Gly Pro Met 
  1               5                  10                  15
Gly Leu Leu Val Val Leu Leu Val Gly Gly Cys Ala Ala Glu Glu Pro 
             20                  25                  30
Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly 
         35                  40                  45
Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val 
     50                  55                  60
Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr 
 65                  70                  75                  80
Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln Pro Leu 
                 85                  90                  95
Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser 
             100                105                110
Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp 
         115                120                125
Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys 
     130                135                140
Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly 
 145                150                155                160
Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp 
                 165                170                175
Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Glu Thr Phe 
             180                185                190
Glu Ser Thr Pro Ile Arg Gly Ala Leu Gln Ile Glu Ser Ser Glu Glu 
         195                200                205
Thr Asp Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly Val 
     210                215                220
Arg Tyr Ser Ser Pro Ala Asn Leu Tyr Val Arg Glu Leu Arg Glu Val 
 225                230                235                240
Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser His Glu Ile 
                 245                250                255
Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val Gly Ser Pro 
             260                265                270
Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu Thr Pro Glu 
         275                280                285
Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr Asp Val Lys 
     290                295                300
Asp Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Ser Leu Gly Val Ile 
 305                310                315                320
Glu Ala Val Ala Gln Ile Thr Val Lys Ser Leu Pro Lys Ala Pro Gly 
                 325                330                335
Thr Pro Met Val Thr Glu Asn Thr Ala Thr Ser Ile Thr Ile Thr Trp 
             340                345                350
Asp Ser Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Ile Glu Tyr Lys 
         355                360                365
Ser Lys Ser Gln Asp Gly Pro Tyr Gln Ile Lys Glu Asp Ile Thr Thr 
     370                375                380
Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu Tyr Glu Ile 
 385                390                395                400
Trp Val Ser Ala Val Asn Ser Ile Gly Gln Gly Pro Pro Ser Glu Ser 
                 405                410                415
Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala Pro Arg Asn 
             420                425                430
Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val Gln Trp Glu 
         435                440                445
Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg Val Tyr Tyr 
     450                455                460
Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys His Asn Val 
 465                470                475                480
Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu Asp Glu Thr 
                 485                490                495
Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp Gly Pro Leu 
             500                505                510
Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro Gly Gln Pro 
         515                520                525
Met Asn Leu Arg Ala Glu Ala Arg Ser Glu Thr Ser Ile Thr Leu Ser 
     530                535                540
Trp Ser Pro Pro Arg Gln Glu Ser Ile Ile Lys Tyr Glu Leu Leu Phe 
 545                550                555                560
Arg Glu Gly Asp His Gly Arg Glu Val Gly Arg Thr Phe Asp Pro Thr 
                 565                570                575
Thr Ser Tyr Val Val Glu Asp Leu Lys Pro Asn Thr Glu Tyr Ala Phe 
             580                585                590
Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe Thr Pro Val 
         595                600                605
Val Arg Gln Arg Thr Leu Gln Ser Lys Pro Ser Ala Pro Pro Gln Asp 
     610                615                620
Val Lys Cys Val Ser Val Arg Ser Thr Ala Ile Leu Val Ser Trp Arg 
 625                630                635                640
Pro Pro Pro Pro Glu Thr His Asn Gly Ala Leu Val Gly Tyr Ser Val 
                 645                650                655
Arg Tyr Arg Pro Leu Gly Ser Glu Asp Pro Glu Pro Lys Glu Val Asn 
             660                665                670
Gly Ile Pro Pro Thr Thr Thr Gln Ile Leu Leu Glu Ala Leu Glu Lys 
         675                680                685
Trp Thr Gln Tyr Arg Ile Thr Thr Val Ala His Thr Glu Val Gly Pro 
     690                695                700
Gly Pro Glu Ser Ser Pro Val Val Val Arg Thr Asp Glu Asp Val Pro 
 705                710                715                720
Ser Ala Pro Pro Arg Lys Val Glu Ala Glu Ala Leu Asn Ala Thr Ala 
                 725                730                735
Ile Arg Val Leu Trp Leu Gly Pro Val Pro Gly Arg Gln His Gly Gln 
             740                745                750
Ile Arg Gly Tyr Gln Val His Tyr Val Arg Met Glu Gly Ala Glu Gly 
         755                760                765
Arg Gly Pro Pro Arg Ile Lys Asp Val Met Leu Ala Asp Ala Gln Trp 
     770                775                780
Glu Thr Asp Asp Thr Ala Glu Tyr Glu Met Val Ile Thr Asn Leu Gln 
 785                790                795                800
Pro Glu Thr Ala Tyr Ser Ile Thr Val Ala Ala Tyr Thr Met Lys Gly 
                 805                810                815
Asp Gly Ala Arg Ser Lys Pro Lys Val Val Val Thr Lys Gly Ala Val 
             820                825                830
Leu Gly Arg Pro Thr Leu Ser Val Gln Gln Thr Pro Glu Gly Ser Leu 
         835                840                845
Leu Ala Arg Trp Glu Pro Pro Ala Gly Thr Ala Glu Asp Gln Val Leu 
     850                855                860
Gly Tyr Arg Leu Gln Phe Gly Arg Glu Asp Ser Thr Pro Leu Ala Thr 
 865                870                875                880
Leu Glu Phe Pro Pro Ser Glu Asp Arg Tyr Thr Ala Ser Gly Val His 
                 885                890                895
Lys Gly Ala Thr Tyr Val Phe Arg Leu Ala Ala Arg Ser Arg Gly Gly 
             900                905                910
Leu Gly Glu Glu Ala Ala Glu Val Leu Ser Ile Pro Glu Asp Thr Pro 
         915                920                925
Arg Gly His Pro Gln Ile Leu Glu Ala Ala Gly Asn Ala Ser Ala Gly 
     930                935                940
Thr Val Leu Leu Arg Trp Leu Pro Pro Val Pro Ala Glu Arg Asn Gly 
 945                950                955                960
Ala Ile Val Lys Tyr Thr Val Ala Val Arg Glu Ala Gly Ala Leu Gly 
                 965                970                975
Pro Ala Arg Glu Thr Glu Leu Pro Ala Ala Ala Glu Pro Gly Ala Glu 
             980                985                990
Asn Ala Val Thr Leu Gln Gly Leu Lys Pro Asp Thr Ala Tyr Asp Leu 
         995                1000                1005
Gln Val Arg Ala His Thr Arg Arg Gly Pro Gly Pro Phe Ser Pro Pro 
     1010                1015                1020
Val Arg Tyr Arg Thr Phe Leu Arg Asp Gln Val Ser Pro Lys Asn Phe 
 1025                1030                1035                1040
Lys Val Lys Met Ile Met Lys Thr Ser Val Leu Leu Ser Trp Glu Phe 
                 1045                1050                1055
Pro Asp Asn Tyr Asn Ser Pro Thr Pro Tyr Lys Ile Gln Tyr Asn Gly 
             1060                1065                1070
Leu Thr Leu Asp Val Asp Gly Arg Thr Thr Lys Lys Leu Ile Thr His 
         1075                1080                1085
Leu Lys Pro His Thr Phe Tyr Asn Phe Val Leu Thr Asn Arg Gly Ser 
     1090                1095                1100
Ser Leu Gly Gly Leu Gln Gln Thr Val Thr Ala Trp Thr Ala Phe Asn 
 1105                1110                1115                1120
Leu Leu Asn Gly Lys Pro Ser Val Ala Pro Lys Pro Asp Ala Asp Gly 
                 1125                1130                1135
Phe Ile Met Val Tyr Leu Pro Asp Gly Gln Ser Pro Val Pro Val Gln 
             1140                1145                1150
Ser Tyr Phe Ile Val Met Val Pro Leu Arg Lys Ser Arg Gly Gly Gln 
         1155                1160                1165
Phe Leu Thr Pro Leu Gly Ser Pro Glu Asp Met Asp Leu Glu Glu Leu 
     1170                1175                1180
Ile Gln Asp Ile Ser Arg Leu Gln Arg Arg Thr Val Arg His Ser Arg 
 1185                1190                1195                1200
Gln Leu Glu Val Pro Arg Pro Tyr Ile Ala Ala Arg Phe Ser Val Leu 
                 1205                1210                1215
Pro Pro Thr Phe His Pro Gly Asp Gln Lys Gln Tyr Gly Gly Phe Asp 
             1220                1225                1230
Asn Arg Gly Leu Glu Pro Gly His Arg Tyr Val Leu Phe Val Leu Ala 
         1235                1240                1245
Val Leu Gln Lys Ser Glu Pro Thr Phe Ala Ala Ser Pro Phe Ser Asp 
     1250                1255                1260
Pro Phe Gln Leu Asp Asn Pro Asp Pro Gln Pro Ile Val Asp Gly Glu 
 1265                1270                1275                1280
Glu Gly Leu Ile Trp Val Ile Gly Pro Val Leu Ala Val Val Phe Ile 
                 1285                1290                1295
Ile Cys Ile Val Ile Ala Ile Leu Leu Tyr Lys Asn Lys Pro Asp Ser 
             1300                1305                1310
Lys Arg Lys Asp Ser Glu Pro Arg Thr Lys Cys Leu Leu Asn Asn Ala 
         1315                1320                1325
Asp Leu Ala Pro His His Pro Lys Asp Pro Val Glu Met Arg Arg Ile 
     1330                1335                1340
Asn Phe Gln Thr Pro Asp Ser Gly Leu Arg Ser Pro Leu Arg Glu Pro 
 1345                1350                1355                1360
Gly Phe His Phe Glu Ser Met Leu Ser His Pro Pro Ile Pro Ile Ala 
                 1365                1370                1375
Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
             1380                1385                1390
Leu Ser Gln Glu Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr Trp 
         1395                1400                1405
Glu His Ser Asn Leu Glu Val Asn Lys Pro Lys Asn Arg Tyr Ala Asn 
     1410                1415                1420
Val Ile Ala Tyr Asp His Phe Arg Val Ile Leu Gln Pro Ile Glu Gly 
 1425                1430                1435                1440
Ile Met Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr Arg 
                 1445                1450                1455
Arg Gln Asn Ala Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Phe 
             1460                1465                1470
Gly Asp Phe Trp Arg Met Val Trp Glu Gln Arg Ser Ala Thr Ile Val 
         1475                1480                1485
Met Met Thr Arg Leu Glu Glu Lys Ser Arg Ile Lys Cys Asp Gln Tyr 
     1490                1495                1500
Trp Pro Asn Arg Gly Thr Glu Thr Tyr Gly Phe Ile Gln Val Thr Leu 
 1505                1510                1515                1520
Leu Asp Thr Ile Glu Leu Ala Thr Phe Cys Val Arg Thr Phe Ser Leu 
                 1525                1530                1535
His Lys Asn Gly Ser Ser Glu Lys Arg Glu Val Arg Gln Phe Gln Phe 
             1540                1545                1550
Thr Ala Trp Pro Asp His Gly Val Pro Glu Tyr Pro Thr Pro Phe Leu 
         1555                1560                1565
Ala Phe Leu Arg Arg Val Lys Thr Cys Asn Pro Pro Asp Ala Gly Pro 
     1570                1575                1580
Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Cys Phe Ile 
 1585                1590                1595                1600
Val Ile Asp Ala Met Leu Glu Arg Ile Lys Pro Glu Lys Thr Val Asp 
                 1605                1610                1615
Val Tyr Gly His Val Thr Leu Met Arg Ser Gln Arg Asn Tyr Met Val 
             1620                1625                1630
Gln Thr Glu Asp Gln Tyr Ser Phe Ile His Glu Ala Leu Leu Glu Ala 
         1635                1640                1645
Val Gly Cys Gly Asn Thr Glu Val Pro Ala Arg Ser Leu Tyr Ala Tyr 
     1650                1655                1660
Ile Gln Lys Leu Ala Gln Val Glu Pro Gly Glu His Val Thr Gly Met 
 1665                1670                1675                1680
Glu Leu Glu Phe Lys Arg Leu Ala Asn Ser Lys Ala His Thr Ser Arg 
                 1685                1690                1695
Phe Ile Ser Ala Asn Leu Pro Cys Asn Lys Phe Lys Asn Arg Leu Val 
             1700                1705                1710
Asn Ile Met Pro Tyr Glu Ser Thr Arg Val Cys Leu Gln Pro Ile Arg 
         1715                1720                1725
Gly Val Glu Gly Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr 
     1730                1735                1740
Arg Gln Gln Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ala Glu Thr 
 1745                1750                1755                1760
Thr Glu Asp Phe Trp Arg Met Leu Trp Glu Asn Asn Ser Thr Ile Val 
                 1765                1770                1775
Val Met Leu Thr Lys Leu Arg Glu Met Gly Arg Glu Lys Cys His Gln 
             1780                1785                1790
Tyr Trp Pro Ala Glu Arg Ser Ala Arg Tyr Gln Tyr Phe Val Val Asp 
         1795                1800                1805
Pro Met Ala Glu Tyr Asn Met Pro Gln Tyr Ile Leu Arg Glu Phe Lys 
     1810                1815                1820
Val Thr Asp Ala Arg Asp Gly Gln Ser Arg Thr Val Arg Gln Phe Gln 
 1825                1830                1835                1840
Phe Thr Asp Trp Pro Glu Gln Gly Val Pro Lys Ser Gly Glu Gly Phe 
                 1845                1850                1855
Ile Asp Phe Ile Gly Gln Val His Lys Thr Lys Glu Gln Phe Gly Gln 
             1860                1865                1870
Asp Gly Pro Ile Ser Val His Cys Ser Ala Gly Val Gly Arg Thr Gly 
         1875                1880                1885
Val Phe Ile Thr Leu Ser Ile Val Leu Glu Arg Met Arg Tyr Glu Gly 
     1890                1895                1900
Val Val Asp Ile Phe Gln Thr Val Lys Met Leu Arg Thr Gln Arg Pro 
 1905                1910                1915                1920
Ala Met Val Gln Thr Glu Asp Glu Tyr Gln Phe Cys Tyr Gln Ala Ala 
                 1925                1930                1935
Leu Glu Tyr Leu Gly Ser Phe Asp His Tyr Ala Thr Ter 
             1940                1945



<210> 2978
<211> 5412
<212> DNA
<213> Rattus norvegicus
<308> L19180
<400> 2978

cagggcgga  gctggaggc  actgccaag  atggcgccc  cctggagac  cagcgtggt  60
tctgtggtg  gtcctgtgg  gctcttcct  gtactgctg  ccagagggt  cttggctga  120
gagccaccc  gatttatca  agagcccaa  gatcagatt  gtgtgtcag  aggcgtggc  180
tccttcgtg  gccaggcca  aggtgaccc  aagccacgg  tgacctgga  caagaaggg  240
aagaaagtg  actcacagc  ctttgagac  attgacttt  acgagagct  gggggccgt  300
ctgaggatc  agccacttc  gacaccccg  gatgagaac  tgtacgagt  tgtggccca  360
aactcggtg  gggagatca  agttcatgc  aagctcacc  tcctgcgag  ggaccagct  420
cctcctggc  tccccaaca  tgacatggg  ccccagttg  aggttgtag  gcgcacacg  480
acagccacc  tgctctgtg  tgccagcgg  aaccctgac  ctgagatca  ctggttcaa  540
gacttcctg  ctgtggacc  cagtgccag  aatgggcgg  tcaagcagc  tcggtcagg  600
gccctgcag  ttgagagca  cgaggagac  gaccagggc  agtacgagt  tgtggccac  660
aaacaggcg  gggtgcgct  ctcatcacc  gccaacctc  acgtgcgag  ccgccgtgt  720
gccccccgc  tctccatcc  gcccatgag  cacgagatc  tgcccggtg  gaatgtgaa  780
atcacttgt  tggctgtgg  ctcacccat  ccctacgtg  agtggatgc  gggggcaga  840
gacctgacg  ctgaggatg  catgcccgt  ggtcggaat  tcctcgaac  cacggatgt  900
aaagactca  ccaactatc  ttgtgtggc  atgtccagc  tgggagtga  cgaggccgt  960
gctgacatc  ctgtaaaat  tctccccaa  gcccctggg  ctcccgtgg  gacggagaa  1020
actgctacc  gtatcactg  cacatggga  gcaggcaat  ctgaccctg  gtcctacta  1080
gtattgagt  taatcaaag  caggatggg  cgtatcaga  caaagaaga  atcaaccac  1140
acgcgctac  gcatcggcg  cctgagccc  aactctgag  atgagatct  ggtgtcagc  1200
gtcaactcc  tcggccagg  ccccagtga  tcggtggtg  cccgcacag  cgagcaggc  1260
ccagccagt  ctcccagga  tgttcaggc  cgcatgctc  gtgccacca  catgattgt  1320
cagtgggag  agcccgtgg  gcccaatgg  ctgatccgt  gctaccgcg  ctactacac  1380
atggagccc  agcatccgg  gggcaactg  cagaagcac  atgtggacg  cagtcttct  1440
accactgtg  gcagcctgc  agaggatga  acctacact  tgagagtgc  cgccttcac  1500
tcggtgggc  atgggccac  gtcagaccc  atccaggtc  agacccagc  gggagtgcc  1560
ggccagccc  tgaacttgc  ggctgaggc  aagtcagag  ccagcattg  gctctcgtg  1620
agtgcacca  ggcaggaga  tgtcattaa  tatgaactg  tcttccggg  gggcgaccg  1680
ggccgagag  tggggcgaa  cttcgaccc  accacagcc  ttgtggtgg  ggacctcaa  1740
cccaatacg  agtacgcgt  ccggctggc  gctcgctcg  cgcagggcc  gggcgcctt  1800
accgcggtt  tgcgccagc  cacactgca  gccatctcc  ccaagaact  caaggtgaa  1860
atgatcatg  aaacttcag  gctgctaag  tgggagttc  ctgacaact  taactcacc  1920
acgccctac  agatccagt  caatggact  acactggac  tggatggcc  cactaccaa  1980
aagctgatc  cgcacctca  gccacacac  ttctataac  tcgtgctca  caaccgtgg  2040
agcagcctg  gaggcctgc  gcagacggt  accgccagg  ccgccttca  catgctcag  2100
ggcaagcct  gtgtcgccc  aaagcctga  aacgatggt  ccattgtgg  ctacctgcc  2160
gatggccag  gtcccgtga  agtgcagaa  tacttcatt  tgatggtcc  acttcggaa  2220
tctcgtggt  gccagttcc  tatcctact  cctagtcca  aggacatgg  tctggagga  2280
ctcatccag  acctctccc  gctgcagag  agcctgcgc  actcaagac  gctggaggt  2340
cctcggcct  acatcgccg  tcggttctc  atcctgcca  ctgtcttcc  tcctgggaa  2400
cagaagcaa  atggtggct  tgacaacag  ggcttggag  caggccacc  ttatgtcct  2460
tttgtactt  ctgtgctgc  gaagaatga  cctacattt  cagccagtc  cttctcaga  2520
cccttccaa  tggacaacc  agacccgca  cccattgtg  atggcgagg  gggcctcat  2580
tgggtgatc  ggcccgtgc  ggccgtggt  ttcatcatc  gcatcgtaa  tgccatcct  2640
ctgtacaag  acaagcctg  cagcaaacg  aaggactca  agccccgca  caaatgctt  2700
ttgaacaat  cagacctcg  cccccatca  cccaaggac  ctgtggaaa  gcgacgtat  2760
aacttccag  cgccaggta  gctcagcca  ccgcccatt  ccatcacag  catggctga  2820
cacatggag  gactcaaag  caacgacag  ctcaagctc  cccaggagt  tgagtccat  2880
gaccctggc  agcagttca  ttgggaaca  tcgaacctg  aggccaaca  gccaaagaa  2940
cgatacgcc  atgtcatcg  ctatgacca  tcacgagtc  tcctgcagc  tttagaagg  3000
atcatgggt  gtgattaca  caatgccaa  tatgttgac  gctatcggc  gcagaacgc  3060
tacatcgcc  cgcaggggc  cctgcctga  acctttggg  acttctggc  gatggtgtg  3120
gagcagcgg  cagccactg  ggtcatgat  acacggctg  aggagaaat  acgggtcaa  3180
tgtgaccag  actggccta  ccgaggcac  gagacatac  gcttcatcc  ggtcaccct  3240
ctagatact  tggagctgg  caccttctg  gtcaggacc  tttctctac  caagaatgg  3300
tctagtgag  agcgtgagg  acgacattt  cagttcaca  catggcctg  ccacggggt  3360
cccgagtac  ccacaccct  cctggcgtt  ctgcgcaga  tcaagacct  caacccgcc  3420
gacgctggc  cagttgtgg  ccactgcag  gcgggtgtg  ggcgtactg  ctgcttcat  3480
gtaattgat  ccatgttgg  gcgcatcag  acagagaag  cggtggatg  gtacggaca  3540
gtgacactc  tgcggtcac  gcgcaacta  atggtgcag  cagaggatc  gtatagctt  3600
atccacgag  cactgctgg  ggctgtggg  tgtggcaat  ccgaggtcc  cgcgcgcag  3660
ctctacacc  atatccaga  gctggccca  gtggagcct  gcgagcatg  cacaggaat  3720
gagcttgag  tcaagaggc  tgcagctcc  aggcacaca  ttcgagatt  attcactgc  3780
agcctgcct  gcaacaagt  taagaaccg  ctggtgaac  tcctgccgt  cgagagctc  3840
cgtgtctgc  tgcagccca  tcgtggtgt  gagggctct  actacatca  tgccagctt  3900
atcgacggc  acagacagc  gaaagccta  attgcaacg  agggtccac  ggcagagac  3960
acagaggac  tctggcgtg  cctgtggga  aacaactcc  ctattgtgg  aatgctcac  4020
aagctccgc  agatgggcc  ggagaagtg  caccagtac  ggccagctg  gcgctctgc  4080
cgctaccag  actttgtgg  tgacccgat  gcagagtat  acatgccag  gtacattct  4140
cgtgagttt  aggtcacag  tgcccggga  ggccagtcc  ggaccgtcc  acagttcac  4200
gactggcca  agcagggtg  acccaagtc  ggggaaggc  tcattgact  catcggcca  4260
gtgcataag  ccaaggagc  gtttggcca  gatggcccc  tctcggtgc  ctgtagtgc  4320
ggagtgggc  ggaccggag  attcatcac  ctgagcatc  tgctggagc  aatgcgcta  4380
gagggggtg  tggacattt  ccagacagt  aaggtgctt  ggacccagc  gcctgccat  4440
gtgcagaca  aggatgagt  ccagttctg  ttccaggcg  cgttggaat  gggcagctt  4500
gatcattat  caacataag  catgggccc  gcaacgcct  gacccagct  caagtgccc  4560
gcatgtgag  ccagccctc  gtgctggtg  gaggcggcc  agggaggaa  cctcctctc  4620
ctggagaca  cactgcctt  taagggcac  ttcctcatt  cttctgact  caaaacgag  4680
ttccagggt  gggggtagg  tggagagta  aggagccac  gctcccata  ctggggtca  4740
aagggacag  actctgctc  cacacttcc  tgcctgcct  cctgtcagc  acattcttt  4800
ttttcattt  tttaactgt  gtgtatttt  cttcatctt  ttttttttt  taagaaaaa  4860
aaaacaatg  gcagtcaaa  tttgaaaac  acgagacac  ttggctctg  ttgtcgctc  4920
gtggagggc  aacttttca  agtaagtgt  tcgtgtggc  gctctgtgc  acaactttg  4980
tggcttctg  gtgcattct  cccacatgt  cccgtgtga  tggctcacg  aggttttct  5040
tttaccctt  ttacttttt  tttaaatca  tcttcagac  tatcagatg  gaaggggtg  5100
tggctggag  acctgggcc  ggctgcagg  catggccac  aggacacag  ggctggcct  5160
actgcccag  ccctgccgc  ccagagagg  tctttgtcc  ctcctgact  atgccccgc  5220
tggaggacc  ccgggacta  ggacacttg  ggacacgca  ccccctaga  caagtgagg  5280
ctctctttg  aggagagtg  gtcagcact  gtccccgct  gttttttgg  cagaagcgg  5340
tgacagccc  gtatgtaga  aaaccaagt  tgtattaat  aagattcgt  cgacctaaa  5400
aaaaaaaaa  aa  5412



<210> 2979
<211> 1496
<212> PRT
<213> Rattus norvegicus
<308> L19180
<400> 2979

Met Ala Pro Thr Trp Arg Pro Ser Val Val Ser Val Val Gly Pro Val 
  1               5                  10                  15
Gly Leu Phe Leu Val Leu Leu Ala Arg Gly Cys Leu Ala Glu Glu Pro 
             20                  25                  30
Pro Arg Phe Ile Arg Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly 
         35                  40                  45
Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val 
     50                  55                  60
Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr 
 65                  70                  75                  80
Ile Asp Phe Asp Glu Ser Ser Gly Ala Val Leu Arg Ile Gln Pro Leu 
                 85                  90                  95
Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser 
             100                105                110
Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp 
         115                120                125
Gln Leu Pro Pro Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys 
     130                135                140
Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly 
 145                150                155                160
Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp 
                 165                170                175
Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Gly Ala Leu 
             180                185                190
Gln Ile Glu Ser Ser Glu Glu Thr Asp Gln Gly Lys Tyr Glu Cys Val 
         195                200                205
Ala Thr Lys Gln Ala Gly Val Arg Tyr Ser Ser Pro Ala Asn Leu Tyr 
     210                215                220
Val Arg Val Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser 
 225                230                235                240
His Glu Ile Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val 
                 245                250                255
Gly Ser Pro Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu 
             260                265                270
Thr Pro Glu Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr 
         275                280                285
Asp Val Lys Asp Ser Ala Asn Tyr Pro Cys Val Ala Met Ser Ser Leu 
     290                295                300
Gly Val Ile Glu Ala Val Ala Asp Ile Thr Val Lys Ser Leu Pro Lys 
 305                310                315                320
Ala Pro Gly Thr Pro Val Val Thr Glu Asn Thr Ala Thr Ser Ile Thr 
                 325                330                335
Val Thr Trp Asp Ala Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Leu 
             340                345                350
Ser Ile Ile Lys Ala Arg Met Gly Arg Ile Arg Ser Lys Lys Thr Ser 
         355                360                365
Thr Thr Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu Tyr 
     370                375                380
Glu Ile Trp Val Ser Ala Val Asn Ser Ile Gly Gln Ala Pro Ser Glu 
 385                390                395                400
Ser Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala Pro Arg 
                 405                410                415
Asn Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val Gln Trp 
             420                425                430
Glu Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg Val Tyr 
         435                440                445
Tyr Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys His Asn 
     450                455                460
Val Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu Asp Glu 
 465                470                475                480
Thr Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp Gly Pro 
                 485                490                495
Leu Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro Gly Gln 
             500                505                510
Pro Met Asn Leu Arg Ala Glu Ala Lys Ser Glu Thr Ser Ile Gly Leu 
         515                520                525
Ser Trp Ser Ala Pro Arg Gln Glu Ser Val Ile Lys Tyr Glu Leu Leu 
     530                535                540
Phe Arg Glu Gly Asp Arg Gly Arg Glu Val Gly Arg Thr Phe Asp Pro 
 545                550                555                560
Thr Thr Ala Phe Val Val Glu Asp Leu Lys Pro Asn Thr Glu Tyr Ala 
                 565                570                575
Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe Thr Ala 
             580                585                590
Val Val Arg Gln Arg Thr Leu Gln Ala Ile Ser Pro Lys Asn Phe Lys 
         595                600                605
Val Lys Met Ile Met Lys Thr Ser Val Leu Leu Ser Trp Glu Phe Pro 
     610                615                620
Asp Asn Tyr Asn Ser Pro Thr Pro Tyr Lys Ile Gln Tyr Asn Gly Leu 
 625                630                635                640
Thr Leu Asp Val Asp Gly Arg Thr Thr Lys Lys Leu Ile Thr His Leu 
                 645                650                655
Lys Pro His Thr Phe Tyr Asn Phe Val Leu Thr Asn Arg Gly Ser Ser 
             660                665                670
Leu Gly Gly Leu Gln Gln Thr Val Thr Ala Arg Thr Ala Phe Asn Met 
         675                680                685
Leu Ser Gly Lys Pro Ser Val Ala Pro Lys Pro Asp Asn Asp Gly Ser 
     690                695                700
Ile Val Val Tyr Leu Pro Asp Gly Gln Ser Pro Val Thr Val Gln Asn 
 705                710                715                720
Tyr Phe Ile Val Met Val Pro Leu Arg Lys Ser Arg Gly Gly Gln Phe 
                 725                730                735
Pro Ile Leu Leu Pro Ser Pro Glu Asp Met Asp Leu Glu Glu Leu Ile 
             740                745                750
Gln Asp Leu Ser Arg Leu Gln Ser Ser Leu Arg His Ser Arg Gln Leu 
         755                760                765
Glu Val Pro Arg Pro Tyr Ile Ala Ala Arg Phe Ser Ile Leu Pro Ala 
     770                775                780
Val Phe His Pro Gly Asn Gln Lys Gln Tyr Gly Gly Phe Asp Asn Arg 
 785                790                795                800
Gly Leu Glu Pro Gly His Arg Tyr Val Leu Phe Val Leu Ala Val Leu 
                 805                810                815
Gln Lys Asn Glu Pro Thr Phe Ala Ala Ser Pro Phe Ser Asp Pro Phe 
             820                825                830
Gln Leu Asp Asn Pro Asp Pro Gln Pro Ile Val Asp Gly Glu Glu Gly 
         835                840                845
Leu Ile Trp Val Ile Gly Pro Val Leu Ala Val Val Phe Ile Ile Cys 
     850                855                860
Ile Val Ile Ala Ile Leu Leu Tyr Lys Asn Lys Pro Asp Ser Lys Arg 
 865                870                875                880
Lys Asp Ser Glu Pro Arg Thr Lys Cys Leu Leu Asn Asn Ala Asp Leu 
                 885                890                895
Ala Pro His His Pro Lys Asp Pro Val Glu Met Arg Arg Ile Asn Phe 
             900                905                910
Gln Thr Pro Gly Met Leu Ser His Pro Pro Ile Pro Ile Thr Asp Met 
         915                920                925
Ala Glu His Met Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser 
     930                935                940
Gln Glu Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr Trp Glu His 
 945                950                955                960
Ser Asn Leu Glu Ala Asn Lys Pro Lys Asn Arg Tyr Ala Asn Val Ile 
                 965                970                975
Ala Tyr Asp His Ser Arg Val Ile Leu Gln Pro Leu Glu Gly Ile Met 
             980                985                990
Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr Arg Arg Gln 
         995                1000                1005
Asn Ala Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Phe Gly Asp 
     1010                1015                1020
Phe Trp Arg Met Val Trp Glu Gln Arg Ser Ala Thr Val Val Met Met 
 1025                1030                1035                1040
Thr Arg Leu Glu Glu Lys Ser Arg Val Lys Cys Asp Gln Tyr Trp Pro 
                 1045                1050                1055
Asn Arg Gly Thr Glu Thr Tyr Gly Phe Ile Gln Val Thr Leu Leu Asp 
             1060                1065                1070
Thr Met Glu Leu Ala Thr Phe Cys Val Arg Thr Phe Ser Leu His Lys 
         1075                1080                1085
Asn Gly Ser Ser Glu Lys Arg Glu Val Arg His Phe Gln Phe Thr Ala 
     1090                1095                1100
Trp Pro Asp His Gly Val Pro Glu Tyr Pro Thr Pro Phe Leu Ala Phe 
 1105                1110                1115                1120
Leu Arg Arg Val Lys Thr Cys Asn Pro Pro Asp Ala Gly Pro Val Val 
                 1125                1130                1135
Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Cys Phe Ile Val Ile 
             1140                1145                1150
Asp Ala Met Leu Glu Arg Ile Arg Thr Glu Lys Thr Val Asp Val Tyr 
         1155                1160                1165
Gly His Val Thr Leu Met Arg Ser Gln Arg Asn Tyr Met Val Gln Thr 
     1170                1175                1180
Glu Asp Gln Tyr Ser Phe Ile His Glu Ala Leu Leu Glu Ala Val Gly 
 1185                1190                1195                1200
Cys Gly Asn Thr Glu Val Pro Ala Arg Ser Leu Tyr Thr Tyr Ile Gln 
                 1205                1210                1215
Lys Leu Ala Gln Val Glu Pro Gly Glu His Val Thr Gly Met Glu Leu 
             1220                1225                1230
Glu Phe Lys Arg Leu Ala Ala Pro Arg His Thr Leu Arg Asp Ser Phe 
         1235                1240                1245
Thr Ala Ser Leu Pro Cys Asn Lys Phe Lys Asn Arg Leu Val Asn Ile 
     1250                1255                1260
Leu Pro Tyr Glu Ser Ser Arg Val Cys Leu Gln Pro Ile Arg Gly Val 
 1265                1270                1275                1280
Glu Gly Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln 
                 1285                1290                1295
Gln Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ala Glu Thr Thr Glu 
             1300                1305                1310
Asp Phe Trp Arg Ala Leu Trp Glu Asn Asn Ser Thr Ile Val Val Met 
         1315                1320                1325
Leu Thr Lys Leu Arg Glu Met Gly Arg Glu Lys Cys His Gln Tyr Trp 
     1330                1335                1340
Pro Ala Glu Arg Ser Ala Arg Tyr Gln Tyr Phe Val Val Asp Pro Met 
 1345                1350                1355                1360
Ala Glu Tyr Asn Met Pro Glu Tyr Ile Leu Arg Glu Phe Lys Val Thr 
                 1365                1370                1375
Asp Ala Arg Asp Gly Gln Ser Arg Thr Val Arg Gln Phe Thr Asp Trp 
             1380                1385                1390
Pro Glu Gln Gly Ala Pro Lys Ser Gly Glu Gly Phe Ile Asp Phe Ile 
         1395                1400                1405
Gly Gln Val His Lys Thr Lys Glu Gln Phe Gly Gln Asp Gly Pro Ile 
     1410                1415                1420
Ser Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Val Phe Ile Thr 
 1425                1430                1435                1440
Leu Ser Ile Val Leu Glu Arg Met Arg Tyr Glu Gly Val Val Asp Ile 
                 1445                1450                1455
Phe Gln Thr Val Lys Val Leu Arg Thr Gln Arg Pro Ala Met Val Gln 
             1460                1465                1470
Thr Glu Asp Glu Tyr Gln Phe Cys Phe Gln Ala Ala Leu Glu Leu Gly 
         1475                1480                1485
Ser Phe Asp His Tyr Ala Thr Ter 
     1490                1495



<210> 2980
<211> 6363
<212> DNA
<213> Homo sapiens
<308> U35234
<400> 2980

cggccagcc  ccagacgtt  ccccatctg  cgctcggct  gaggcctct  tgtgaggga  60
cggggggcc  tccccctcc  gggcggaga  cggaggtcg  tgccaagca  ggcgcccac  120
tggggccct  gcatggtgt  tgtggttgg  cccatgggc  tccttgtgg  cctgctcgt  180
ggaggctgt  cagcagaag  gccccccag  tttatcaaa  aacccaagg  ccagatcgg  240
gtgtcgggg  gtgtggcct  tttcgtgtg  caggccacg  gtgacccca  gccacgagt  300
acctggaac  agaagggca  gaaggtcaa  tctcagcgc  ttgagacga  tgagtttga  360
gagagtgcc  gggcagtgc  gaggatcca  ccgctgagg  caccgcggg  tgaaaacgt  420
tacgagtgt  tggcccaga  ctcggttgg  gagatcaca  tccatgcca  gcttactgt  480
ctccgagag  accagctgc  ctctggctt  cccaacatc  acatgggcc  acagttgaa  540
gtggtggag  ggacacgga  agccaccat  ctctgtgca  ccagcggca  ccctgaccc  600
gagatcacc  ggttcaagg  cttcctgcc  gtggatcct  gtgccagca  tggacgcat  660
aaacagctg  gatcagaaa  ctttgaaag  actccgatt  gaggagccc  gcagattga  720
agcagtgag  aaaccgacc  gggcaaata  gagtgtgtg  ccaccaaca  cgccggcgt  780
cgctactcc  cacctgcca  cctctacgt  cgagagctt  gagaagtcc  ccgcgtggc  840
ccgcgcttc  ccatcctgc  catgagcca  gagatcatg  cagggggca  cgtgaacat  900
acctgcgtg  ccgtgggct  gcccatgcc  tacgtgaag  ggatgcagg  ggccgagga  960
ctgaccccc  aggatgaca  gcccgtggg  cggaacgtg  tggaactca  agatgtcaa  1020
gactcggcc  actacacct  cgtggccat  tccagcctg  gcgtcattg  ggcggttgc  1080
cagatcacg  tgaaatctc  ccccaaagc  cccgggact  ccatggtga  tgagaacac  1140
gccaccagc  tcaccatca  gtgggactc  ggcaaccca  atcctgtgt  ctattacgt  1200
atcgaatat  aatccaaga  ccaagacgg  ccgtatcag  ttaaagagg  catcaccac  1260
acacgttac  gcatcggcg  cctgagccc  aactcggag  acgagatct  ggtgtcggc  1320
gtcaactcc  tcggccagg  gccccccag  gagtccgtg  tcacccgca  aggcgagca  1380
gccccggcc  gcgcgccgc  gaacgtgca  gcccggatg  tcagcgcga  caccatgat  1440
gtgcagtgg  aggagccgg  ggagcccaa  ggcctgatc  gcggctacc  cgtctacta  1500
accatggaa  cggagcacc  cgtgggcaa  tggcagaag  acaacgtgg  cgacagcct  1560
ctgaccacc  tgggcagcc  gctggagga  gagacctac  ccgtgcggg  gctcgcctt  1620
acctccgtc  gcgacgggc  cctctcgga  cccatccag  tcaagacgc  gcagggagt  1680
ccgggccag  ccatgaacc  gcgggccga  gccaggtcg  agaccagca  cacgctgtc  1740
tggagcccc  cgcggcagg  gagtatcat  aagtacgag  tcctcttcc  ggaaggcga  1800
catggccgg  aggtgggaa  gaccttcga  ccgacgact  cctacgtgg  ggaggacct  1860
aagcccaac  cggagtacg  cttccgcct  gccgcccgc  cgccgcagg  cctgggcgc  1920
ttcaccccc  tggtgcggc  gcgcacgct  cagtccaaa  cgtcagccc  ccctcaaga  1980
gttaaatgt  tcagcgtgc  ctccacggc  attttggta  gttggcgcc  gccgccgcc  2040
gaaacgcac  acggggccc  ggtgggcta  agcgtccgc  accgaccgc  gggctcaga  2100
gacccggaa  ccaaggagg  gaacggcat  cccccgacc  ccactcaga  cctgctgga  2160
gccttggag  agtggaccc  gtaccgcat  acgactgtc  ctcacacag  ggtgggacc  2220
gggcccgag  gctcacccg  ggtcgtccg  accgacgag  atgtgccca  cgcgccgcc  2280
cggaaggtg  aggcggagg  gctcaacgc  acggccatc  gcgtgctgt  gctcggccc  2340
gtgcccggc  ggcagcacg  ccagatccg  ggctaccag  tccactacg  gcgcatgga  2400
ggcgccgag  gccgcgggc  gccgcgcat  aaggacgtc  tgctggccg  tgcccagtg  2460
gagacggat  acacggccg  atatgagat  gtcatcaca  acttgcagc  tgagaccgc  2520
tactccatc  cggtagccg  ctacaccat  aagggcgat  gcgctcgca  caaacccaa  2580
gtggttgtg  ccaagggag  agtgttggg  cgcccaacc  tgtcggtgc  gcagacccc  2640
gagggcagc  tgctggcac  ctgggagcc  ccggctggc  ccgcggagg  ccaggtgct  2700
ggctaccgc  tgcagtttg  ccgtgagga  tcgacgccc  tggccaccc  ggagttccc  2760
ccctccgag  accgctaca  ggcatcagg  gtgcacaag  gggccacgt  tgtgttccg  2820
cttgcggcc  ggagccggg  cggcctggg  gaggaggca  ccgaggtcc  gagcatccc  2880
gaggacacg  cccgtggcc  cccgcagat  ttggaagcc  ccggcaacg  ctcggccgg  2940
accgtcctt  tccgctggc  gccacccgt  cccgccgag  gcaacgggg  catcgtcaa  3000
tacacggtg  ccgtgcgtg  ggccggtgc  ctgggccct  cccgagaga  tgagctgcc  3060
gcagcggct  agccgggcg  ggagaacgc  gtcacgctg  agggcctga  gcccgacac  3120
gcctatgac  tccaagtgc  agcccacac  cgccggggc  ctggcccct  cagcccccc  3180
gtccgctac  ggacgttcc  gcgggacca  gtctcgccc  agaacttca  ggtgaaaat  3240
atcatgaag  catcagttc  gctcagctg  gagttccct  acaactaca  ctcacccac  3300
ccctacaag  tccagtaca  tgggctcac  ctggatgtg  atggccgta  caccaagaa  3360
ctcatcacg  acctcaagc  ccacacctt  tacaacttt  tgctgacca  tcgcggcag  3420
agcctgggc  gcctccagc  gacggtcac  gcctggact  ccttcaacc  gctcaacgg  3480
aagcccagc  tcgccccca  gcctgatgc  gacggcttc  tcatggtgt  tcttcctga  3540
ggccagagc  ccgtgcctg  ccagagcta  ttcattgtg  tggtgccac  gcgcaagtc  3600
cgtggaggc  aattcctga  cccgctggg  agcccagag  acatggatc  ggaagagct  3660
atccaggac  tctcacggc  acagaggcg  accgtgcgg  actcgcgtc  gctggaggt  3720
ccccggccc  atattgcag  tcgcttctc  gtgctgcca  ccacgttcc  tcccggcga  3780
cagaagcag  atggcggct  cgataaccg  ggcctggag  ccggccacc  ctatgtcct  3840
ttcgtgctt  ccgtgcttc  gaagagcga  cctaccttt  cagccagtc  cttctcaga  3900
cccttccag  tggataacc  ggaccccca  cccatcgtg  atggcgagg  ggggcttat  3960
tgggtgatc  ggcctgtgc  ggccgtggt  ttcataatc  gcattgtca  tgctatcct  4020
ctctacaag  acaaacccg  cagtaaacg  aaggactca  aaccccgca  caaatgcct  4080
ctgaacaat  ccgacctcg  ccctcacca  cccaaggac  ctgtggaaa  gagacgcat  4140
aacttccag  ctccagatt  aggcctcag  agccccctc  gggagccgg  gtttcactt  4200
gaaagcatg  ttagccacc  gccaattcc  atcgcagac  tggcggagc  cacggagcg  4260
ctcaaggcc  acgacagcc  caagctctc  caggagtat  agtccatcg  ccctggaca  4320
cagttcaca  gggaacatt  caacctgga  gtgaacaag  cgaagaacc  ctatgccaa  4380
gtcatcgcc  atgaccact  ccgtgtcat  ctccagccc  ttgaaggca  catgggcag  4440
gattacatc  atgccaact  tgtggacgg  taccggcgt  agaacgcgt  cattgccac  4500
caggggccg  tgcctgaga  ctttgggga  ttctggcgt  tggtgtggg  gcagcggtc  4560
gcgaccatc  tcatgatga  gcggctgga  gagaagtca  ggatcaagt  tgatcagta  4620
tggcccaac  gaggcacgg  gacctacgg  ttcatccag  tcacgttgc  agataccat  4680
gagctggcc  cattctgcg  caggacatt  tctctgcac  agaatggct  cagtgagaa  4740
cgcgaggtc  gccagttcc  gtttacggc  tggccggac  atggcgtgc  cgaataccc  4800
acgcccttc  tggctttcc  gcggagagt  aagacctgc  acccgccag  tgccggccc  4860
atcgtggtt  actgcagtg  cggtgtggg  cgcacaggc  gctttatcg  catcgacgc  4920
atgcttgag  ggatcaagc  agagaagac  gtcgatgtc  atggccacg  gacgctcat  4980
aggtcccag  gcaactaca  ggtgcagac  gaggaccag  acagcttca  ccacgaggc  5040
ctgctggag  ccgtgggct  tggcaacac  gaagtgccc  cacgcagcc  ctatgccta  5100
atccagaag  tggcccagg  ggagcctgg  gaacacgtc  ctggcatgg  actcgagtt  5160
aagcggctg  ctaactcca  ggcccacac  tcacgcttc  tcagtgcca  tctgccttg  5220
aacaagttc  agaaccgcc  ggtgaacat  atgccctat  agagcacac  ggtctgtct  5280
caacccatc  ggggtgtgg  gggctctga  tacatcaac  ccagcttca  tgatggcta  5340
aggcagcag  aggcctaca  cgcgacaca  gggccgctg  cggagacca  ggaagactt  5400
tggcgcatg  tgtgggaga  caattcgac  atcgtggtg  tgctgacca  gctgcggga  5460
atgggccgg  agaagtgtc  ccagtactg  ccggccgag  gctctgccc  ctaccagta  5520
tttgtggta  atccgatgg  agaatacaa  atgcctcag  atatcctgc  agagttcaa  5580
gtcacagat  cccgggatg  ccagtcccg  actgtccgg  agttccagt  cacagactg  5640
ccggaacag  gtgtgccaa  gtcggggga  ggcttcatc  acttcattg  ccaagtgca  5700
aagactaag  agcagtttg  ccaggacgg  cccatctct  tccactgca  tgccggcgt  5760
ggcaggacg  gcgtcttca  cacgcttag  atcgtgctg  agcggatgc  gtatgaagg  5820
gtggtggac  tctttcaga  ggtgaagat  ctacgaacc  agcggccgg  catggtgca  5880
acagaggat  agtaccagt  ctgttacca  gcggcactg  agtacctcg  aagctttga  5940
cactatgca  cctaaagcc  tggtccccc  caggcccga  accactggc  ccggatgcc  6000
ctgcccctc  cgggcggac  tcctgaggc  tggaccccc  gtgggcagg  caggaggtg  6060
cagcggcag  agctgtgtt  ttctgcacc  tttccgagg  cgacgcatc  cctcgagcc  6120
ccccaccgg  cccggccgc  ccagcgacc  ccctggcac  ggccgccgc  ttcaaatac  6180
tggcacatt  ctcctttcc  tccaattcc  aaaccagat  ccggggtgg  gggtggggg  6240
atggtgagc  aataggagt  ctccccaga  ccagaggag  gtggggcac  gaccataga  6300
ggacccctc  tcctccccc  gcggtggta  ggggacccg  ggggctcct  cccgctctg  6360
acc  6363



<210> 2981
<211> 1949
<212> PRT
<213> Homo sapiens
<308> U35234
<400> 2981

Met Ala Pro Thr Trp Gly Pro Gly Met Val Ser Val Val Gly Pro Met 
  1               5                  10                  15
Gly Leu Leu Val Val Leu Leu Val Gly Gly Cys Ala Ala Glu Glu Pro 
             20                  25                  30
Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly 
         35                  40                  45
Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val 
     50                  55                  60
Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr 
 65                  70                  75                  80
Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln Pro Leu 
                 85                  90                  95
Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser 
             100                105                110
Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp 
         115                120                125
Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys 
     130                135                140
Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly 
 145                150                155                160
Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp 
                 165                170                175
Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Glu Thr Phe 
             180                185                190
Glu Ser Thr Pro Ile Arg Gly Ala Leu Gln Ile Glu Ser Ser Glu Glu 
         195                200                205
Thr Asp Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly Val 
     210                215                220
Arg Tyr Ser Ser Pro Ala Asn Leu Tyr Val Arg Glu Leu Arg Glu Val 
 225                230                235                240
Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser His Glu Ile 
                 245                250                255
Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val Gly Ser Pro 
             260                265                270
Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu Thr Pro Glu 
         275                280                285
Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr Asp Val Lys 
     290                295                300
Asp Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Ser Leu Gly Val Ile 
 305                310                315                320
Glu Ala Val Ala Gln Ile Thr Val Lys Ser Leu Pro Lys Ala Pro Gly 
                 325                330                335
Thr Pro Met Val Thr Glu Asn Thr Ala Thr Ser Ile Thr Ile Thr Trp 
             340                345                350
Asp Ser Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Ile Glu Tyr Lys 
         355                360                365
Ser Lys Ser Gln Asp Gly Pro Tyr Gln Ile Lys Glu Asp Ile Thr Thr 
     370                375                380
Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu Tyr Glu Ile 
 385                390                395                400
Trp Val Ser Ala Val Asn Ser Ile Gly Gln Gly Pro Pro Ser Glu Ser 
                 405                410                415
Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala Pro Arg Asn 
             420                425                430
Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val Gln Trp Glu 
         435                440                445
Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg Val Tyr Tyr 
     450                455                460
Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys His Asn Val 
 465                470                475                480
Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu Asp Glu Thr 
                 485                490                495
Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp Gly Pro Leu 
             500                505                510
Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro Gly Gln Pro 
         515                520                525
Met Asn Leu Arg Ala Glu Ala Arg Ser Glu Thr Ser Ile Thr Leu Ser 
     530                535                540
Trp Ser Pro Pro Arg Gln Glu Ser Ile Ile Lys Tyr Glu Leu Leu Phe 
 545                550                555                560
Arg Glu Gly Asp His Gly Arg Glu Val Gly Arg Thr Phe Asp Pro Thr 
                 565                570                575
Thr Ser Tyr Val Val Glu Asp Leu Lys Pro Asn Thr Glu Tyr Ala Phe 
             580                585                590
Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe Thr Pro Val 
         595                600                605
Val Arg Gln Arg Thr Leu Gln Ser Lys Pro Ser Ala Pro Pro Gln Asp 
     610                615                620
Val Lys Cys Val Ser Val Arg Ser Thr Ala Ile Leu Val Ser Trp Arg 
 625                630                635                640
Pro Pro Pro Pro Glu Thr His Asn Gly Ala Leu Val Gly Tyr Ser Val 
                 645                650                655
Arg Tyr Arg Pro Leu Gly Ser Glu Asp Pro Glu Pro Lys Glu Val Asn 
             660                665                670
Gly Ile Pro Pro Thr Thr Thr Gln Ile Leu Leu Glu Ala Leu Glu Lys 
         675                680                685
Trp Thr Gln Tyr Arg Ile Thr Thr Val Ala His Thr Glu Val Gly Pro 
     690                695                700
Gly Pro Glu Ser Ser Pro Val Val Val Arg Thr Asp Glu Asp Val Pro 
 705                710                715                720
Ser Ala Pro Pro Arg Lys Val Glu Ala Glu Ala Leu Asn Ala Thr Ala 
                 725                730                735
Ile Arg Val Leu Trp Leu Gly Pro Val Pro Gly Arg Gln His Gly Gln 
             740                745                750
Ile Arg Gly Tyr Gln Val His Tyr Val Arg Met Glu Gly Ala Glu Gly 
         755                760                765
Arg Gly Pro Pro Arg Ile Lys Asp Val Met Leu Ala Asp Ala Gln Trp 
     770                775                780
Glu Thr Asp Asp Thr Ala Glu Tyr Glu Met Val Ile Thr Asn Leu Gln 
 785                790                795                800
Pro Glu Thr Ala Tyr Ser Ile Thr Val Ala Ala Tyr Thr Met Lys Gly 
                 805                810                815
Asp Gly Ala Arg Ser Lys Pro Lys Val Val Val Thr Lys Gly Ala Val 
             820                825                830
Leu Gly Arg Pro Thr Leu Ser Val Gln Gln Thr Pro Glu Gly Ser Leu 
         835                840                845
Leu Ala Arg Trp Glu Pro Pro Ala Gly Thr Ala Glu Asp Gln Val Leu 
     850                855                860
Gly Tyr Arg Leu Gln Phe Gly Arg Glu Asp Ser Thr Pro Leu Ala Thr 
 865                870                875                880
Leu Glu Phe Pro Pro Ser Glu Asp Arg Tyr Thr Ala Ser Gly Val His 
                 885                890                895
Lys Gly Ala Thr Tyr Val Phe Arg Leu Ala Ala Arg Ser Arg Gly Gly 
             900                905                910
Leu Gly Glu Glu Ala Ala Glu Val Leu Ser Ile Pro Glu Asp Thr Pro 
         915                920                925
Arg Gly His Pro Gln Ile Leu Glu Ala Ala Gly Asn Ala Ser Ala Gly 
     930                935                940
Thr Val Leu Leu Arg Trp Leu Pro Pro Val Pro Ala Glu Arg Asn Gly 
 945                950                955                960
Ala Ile Val Lys Tyr Thr Val Ala Val Arg Glu Ala Gly Ala Leu Gly 
                 965                970                975
Pro Ala Arg Glu Thr Glu Leu Pro Ala Ala Ala Glu Pro Gly Ala Glu 
             980                985                990
Asn Ala Val Thr Leu Gln Gly Leu Lys Pro Asp Thr Ala Tyr Asp Leu 
         995                1000                1005
Gln Val Arg Ala His Thr Arg Arg Gly Pro Gly Pro Phe Ser Pro Pro 
     1010                1015                1020
Val Arg Tyr Arg Thr Phe Leu Arg Asp Gln Val Ser Pro Lys Asn Phe 
 1025                1030                1035                1040
Lys Val Lys Met Ile Met Lys Thr Ser Val Leu Leu Ser Trp Glu Phe 
                 1045                1050                1055
Pro Asp Asn Tyr Asn Ser Pro Thr Pro Tyr Lys Ile Gln Tyr Asn Gly 
             1060                1065                1070
Leu Thr Leu Asp Val Asp Gly Arg Thr Thr Lys Lys Leu Ile Thr His 
         1075                1080                1085
Leu Lys Pro His Thr Phe Tyr Asn Phe Val Leu Thr Asn Arg Gly Ser 
     1090                1095                1100
Ser Leu Gly Gly Leu Gln Gln Thr Val Thr Ala Trp Thr Ala Phe Asn 
 1105                1110                1115                1120
Leu Leu Asn Gly Lys Pro Ser Val Ala Pro Lys Pro Asp Ala Asp Gly 
                 1125                1130                1135
Phe Ile Met Val Tyr Leu Pro Asp Gly Gln Ser Pro Val Pro Val Gln 
             1140                1145                1150
Ser Tyr Phe Ile Val Met Val Pro Leu Arg Lys Ser Arg Gly Gly Gln 
         1155                1160                1165
Phe Leu Thr Pro Leu Gly Ser Pro Glu Asp Met Asp Leu Glu Glu Leu 
     1170                1175                1180
Ile Gln Asp Ile Ser Arg Leu Gln Arg Arg Thr Val Arg His Ser Arg 
 1185                1190                1195                1200
Gln Leu Glu Val Pro Arg Pro Tyr Ile Ala Ala Arg Phe Ser Val Leu 
                 1205                1210                1215
Pro Pro Thr Phe His Pro Gly Asp Gln Lys Gln Tyr Gly Gly Phe Asp 
             1220                1225                1230
Asn Arg Gly Leu Glu Pro Gly His Arg Tyr Val Leu Phe Val Leu Ala 
         1235                1240                1245
Val Leu Gln Lys Ser Glu Pro Thr Phe Ala Ala Ser Pro Phe Ser Asp 
     1250                1255                1260
Pro Phe Gln Leu Asp Asn Pro Asp Pro Gln Pro Ile Val Asp Gly Glu 
 1265                1270                1275                1280
Glu Gly Leu Ile Trp Val Ile Gly Pro Val Leu Ala Val Val Phe Ile 
                 1285                1290                1295
Ile Cys Ile Val Ile Ala Ile Leu Leu Tyr Lys Asn Lys Pro Asp Ser 
             1300                1305                1310
Lys Arg Lys Asp Ser Glu Pro Arg Thr Lys Cys Leu Leu Asn Asn Ala 
         1315                1320                1325
Asp Leu Ala Pro His His Pro Lys Asp Pro Val Glu Met Arg Arg Ile 
     1330                1335                1340
Asn Phe Gln Thr Pro Asp Ser Gly Leu Arg Ser Pro Leu Arg Glu Pro 
 1345                1350                1355                1360
Gly Phe His Phe Glu Ser Met Leu Ser His Pro Pro Ile Pro Ile Ala 
                 1365                1370                1375
Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
             1380                1385                1390
Leu Ser Gln Glu Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr Trp 
         1395                1400                1405
Glu His Ser Asn Leu Glu Val Asn Lys Pro Lys Asn Arg Tyr Ala Asn 
     1410                1415                1420
Val Ile Ala Tyr Asp His Phe Arg Val Ile Leu Gln Pro Ile Glu Gly 
 1425                1430                1435                1440
Ile Met Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr Arg 
                 1445                1450                1455
Arg Gln Asn Ala Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Phe 
             1460                1465                1470
Gly Asp Phe Trp Arg Met Val Trp Glu Gln Arg Ser Ala Thr Ile Val 
         1475                1480                1485
Met Met Thr Arg Leu Glu Glu Lys Ser Arg Ile Lys Cys Asp Gln Tyr 
     1490                1495                1500
Trp Pro Asn Arg Gly Thr Glu Thr Tyr Gly Phe Ile Gln Val Thr Leu 
 1505                1510                1515                1520
Leu Asp Thr Ile Glu Leu Ala Thr Phe Cys Val Arg Thr Phe Ser Leu 
                 1525                1530                1535
His Lys Asn Gly Ser Ser Glu Lys Arg Glu Val Arg Gln Phe Gln Phe 
             1540                1545                1550
Thr Ala Trp Pro Asp His Gly Val Pro Glu Tyr Pro Thr Pro Phe Leu 
         1555                1560                1565
Ala Phe Leu Arg Arg Val Lys Thr Cys Asn Pro Pro Asp Ala Gly Pro 
     1570                1575                1580
Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Cys Phe Ile 
 1585                1590                1595                1600
Val Ile Asp Ala Met Leu Glu Arg Ile Lys Pro Glu Lys Thr Val Asp 
                 1605                1610                1615
Val Tyr Gly His Val Thr Leu Met Arg Ser Gln Arg Asn Tyr Met Val 
             1620                1625                1630
Gln Thr Glu Asp Gln Tyr Ser Phe Ile His Glu Ala Leu Leu Glu Ala 
         1635                1640                1645
Val Gly Cys Gly Asn Thr Glu Val Pro Ala Arg Ser Leu Tyr Ala Tyr 
     1650                1655                1660
Ile Gln Lys Leu Ala Gln Val Glu Pro Gly Glu His Val Thr Gly Met 
 1665                1670                1675                1680
Glu Leu Glu Phe Lys Arg Leu Ala Asn Ser Lys Ala His Thr Ser Arg 
                 1685                1690                1695
Phe Ile Ser Ala Asn Leu Pro Cys Asn Lys Phe Lys Asn Arg Leu Val 
             1700                1705                1710
Asn Ile Met Pro Tyr Glu Ser Thr Arg Val Cys Leu Gln Pro Ile Arg 
         1715                1720                1725
Gly Val Glu Gly Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr 
     1730                1735                1740
Arg Gln Gln Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ala Glu Thr 
 1745                1750                1755                1760
Thr Glu Asp Phe Trp Arg Met Leu Trp Glu Asn Asn Ser Thr Ile Val 
                 1765                1770                1775
Val Met Leu Thr Lys Leu Arg Glu Met Gly Arg Glu Lys Cys His Gln 
             1780                1785                1790
Tyr Trp Pro Ala Glu Arg Ser Ala Arg Tyr Gln Tyr Phe Val Val Asp 
         1795                1800                1805
Pro Met Ala Glu Tyr Asn Met Pro Gln Tyr Ile Leu Arg Glu Phe Lys 
     1810                1815                1820
Val Thr Asp Ala Arg Asp Gly Gln Ser Arg Thr Val Arg Gln Phe Gln 
 1825                1830                1835                1840
Phe Thr Asp Trp Pro Glu Gln Gly Val Pro Lys Ser Gly Glu Gly Phe 
                 1845                1850                1855
Ile Asp Phe Ile Gly Gln Val His Lys Thr Lys Glu Gln Phe Gly Gln 
             1860                1865                1870
Asp Gly Pro Ile Ser Val His Cys Ser Ala Gly Val Gly Arg Thr Gly 
         1875                1880                1885
Val Phe Ile Thr Leu Ser Ile Val Leu Glu Arg Met Arg Tyr Glu Gly 
     1890                1895                1900
Val Val Asp Ile Phe Gln Thr Val Lys Met Leu Arg Thr Gln Arg Pro 
 1905                1910                1915                1920
Ala Met Val Gln Thr Glu Asp Glu Tyr Gln Phe Cys Tyr Gln Ala Ala 
                 1925                1930                1935
Leu Glu Tyr Leu Gly Ser Phe Asp His Tyr Ala Thr Ter 
             1940                1945



<210> 2982
<211> 1780
<212> DNA
<213> Rattus norvegicus
<308> L19341
<400> 2982

tgtgctggg  gtgccccag  gctggcttt  actgtacgc  gtcaggctc  ccctggacc  60
cacggaaca  cattgccag  cacacggct  ccaacaaat  acctctttt  atgctgttt  120
gcacagatc  aatctacag  ttatacaat  gtcgatgga  caatgatcc  ttctgtgct  180
atgatgatg  ctctccctt  cccgagtat  gaagatgag  agcccaagg  caacccgaa  240
ctttacatg  gtgtgtgtg  gggcctctc  tgcgggaac  aggaccact  tgagggcca  300
cagtgtttt  cctccctga  cgtcaatga  ggcttccgc  tctaccaga  gggctgctt  360
caggtctat  agcagggga  gatgacgtg  aagaccccg  cgtcgcctg  ccaggctgt  420
gagtgctgc  aaggggact  gtgcaacag  aacgtcacg  cccggctgc  cactaaagg  480
aaatccttc  ctggatcgc  gaacttcca  ctggaagtt  gccttatca  cctctccgt  540
gtgtttgcg  tatgccttt  cgcttgcat  cttggcgtt  ctctcagga  gtttaaaag  600
cgcaatcaa  agcgcctga  ccccagaga  gtggagtac  gtactatcg  agggctcat  660
accaccaac  tcggagata  cactctagc  gaattacta  atcactcat  tacatcagg  720
agtggctcc  gtcttcctt  tctggtaca  agaactgtg  ctcgacaga  aaccctgtt  780
gagtgtgtc  ggaagggcc  gtatggaga  gtgtggagg  gcagctggc  aggcgaaaa  840
gttgctgtg  agatcttct  ctcccgtga  gagaagtcg  ggttcaggg  gacagaatt  900
tacaacacg  ttatgctga  gcatgagaa  atcttaggt  tcattgctt  agacatgac  960
tctagacac  ccagtaccc  gctgtggct  attacacat  accacgaaa  gggatcgtt  1020
tatgactac  ttcagctca  cactctgga  acggttagc  gccttcgga  cgtgttgtc  1080
atagccagc  gccttgcac  cttgcacat  gagatattt  ggacccagg  gaagtctgc  1140
atcgcccac  gagatctaa  gagcaaaaa  atcctcgtg  agaagaacg  acagtgctg  1200
atagcagat  tgggcctgg  agtcatgca  tcccagagc  cgaatcagc  tgatgtggg  1260
aacaacccc  gtgtgggga  caagcgcta  atggcccct  aagtgcttg  tgaaaccat  1320
caagtggat  gctttgatt  ttataagag  gtcgatatt  gggcctttg  cctcgttct  1380
tgggaagtg  ccaggagga  ggtgagcaa  ggtatagtg  aagattaca  gccaccatt  1440
tatgatgtt  ttcccaatg  cccaagttt  gaagatatg  ggaaagttg  ctgtgtgga  1500
caacagagg  caaacatac  taacagatg  ttctcagac  cgacattaa  ttctctggc  1560
aagctgatg  aagaatgct  gtaccagaa  ccatccgcc  gactcacag  tctacgtat  1620
aaaaagact  tgaccaaaa  tgataactc  ctagacaaa  taaaaactg  ctgttgaca  1680
tgtcaccgg  gtcaagaag  agagtcaat  ctgtcattg  ccagctggg  cctaatgct  1740
gcctgactg  ttgtcagaa  agaatccat  tgtccccctc  1780



<210> 2983
<211> 509
<212> PRT
<213> Rattus norvegicus
<308> P80201
<400> 2983

Met Val Asp Gly Ala Met Ile Leu Ser Val Leu Met Met Met Ala Leu 
  1               5                  10                  15
Pro Ser Pro Ser Met Glu Asp Glu Glu Pro Lys Val Asn Pro Lys Leu 
             20                  25                  30
Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
         35                  40                  45
Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Val Asn Asp Gly Phe Arg 
     50                  55                  60
Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr 
 65                  70                  75                  80
Cys Lys Thr Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys Gln Gly 
                 85                  90                  95
Asp Trp Cys Asn Arg Asn Val Thr Ala Arg Leu Pro Thr Lys Gly Lys 
             100                105                110
Ser Phe Pro Gly Ser Gln Asn Phe His Leu Glu Val Gly Leu Ile Ile 
         115                120                125
Leu Ser Val Val Phe Ala Val Cys Leu Phe Ala Cys Ile Leu Gly Val 
     130                135                140
Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn Pro Arg 
 145                150                155                160
Asp Val Glu Tyr Gly Thr Ile Glu Gly Leu Ile Thr Thr Asn Val Gly 
                 165                170                175
Asp Ser Thr Leu Ala Glu Leu Leu Asp His Ser Cys Thr Ser Gly Ser 
             180                185                190
Gly Ser Gly Leu Pro Phe Leu Val Gln Arg Thr Val Ala Arg Gln Ile 
         195                200                205
Thr Leu Leu Glu Cys Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
     210                215                220
Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys Ile Phe Ser Ser Arg 
 225                230                235                240
Asp Glu Lys Ser Trp Phe Arg Glu Thr Glu Leu Tyr Asn Thr Val Met 
                 245                250                255
Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Thr Ser 
             260                265                270
Arg His Ser Ser Thr Gln Leu Trp Leu Ile Thr His Tyr His Glu Met 
         275                280                285
Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Thr Thr Leu Asp Thr Val Ser 
     290                295                300
Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly Leu Ala His Leu His 
 305                310                315                320
Ile Glu Ile Phe Gly Thr Gln Gly Lys Ser Ala Ile Ala His Arg Asp 
                 325                330                335
Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Gln Cys Cys Ile 
             340                345                350
Ala Asp Leu Gly Leu Ala Val Met His Ser Gln Ser Thr Asn Gln Leu 
         355                360                365
Asp Val Gly Asn Asn Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
     370                375                380
Glu Val Leu Asp Glu Thr Ile Gln Val Asp Cys Phe Asp Ser Tyr Lys 
 385                390                395                400
Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Val Ala Arg 
                 405                410                415
Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr Lys Pro Pro Phe Tyr 
             420                425                430
Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Arg Lys Val Val 
         435                440                445
Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn Arg Trp Phe Ser Asp 
     450                455                460
Pro Thr Leu Thr Ser Leu Ala Lys Leu Met Lys Glu Cys Trp Tyr Gln 
 465                470                475                480
Asn Pro Ser Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Thr 
                 485                490                495
Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Thr Asp Cys 
             500                505



<210> 2984
<211> 2952
<212> DNA
<213> Homo sapiens
<308> NM_001105
<400> 2984

gaagcgaat  gcgttttca  agatattgg  cggctcaag  gtcttactc  gtcgcccag  60
ctgtaatgc  gtgctgtga  catagccca  tgcagcctc  acctcccag  ctcaagcag  120
ccttccccc  tcgccctca  gaatagctg  gactacagc  tggagcatt  gtaagcgtc  180
cactgccaa  gtgagagct  ctggagaac  cataatccc  ggaacgcct  ttctactct  240
cgagtaccc  agtgaccag  gtgagagaa  ctctgaacg  gggcacgcg  cttgaagga  300
tgtgggcag  tgtgaccaa  agcctgcat  aagttgtac  atggtagat  gagtgatga  360
tcttcctgt  cttatcatg  ttgctctcc  ctcccctag  atggaagat  agaagccca  420
ggtcaaccc  aaactctac  tgtgtgtgt  tgaaggtct  tcctgcggt  atgaggacc  480
ctgtgaagg  cagcagtgc  tttcctcac  gagcatcaa  gatggcttc  acgtctacc  540
gaaaggctg  ttccaggtt  atgagcagg  aaagatgac  tgtaagacc  cgccgtccc  600
tggccaagc  gtggagtgc  gccaagggg  ctggtgtaa  aggaacatc  cggcccagc  660
gcccactaa  ggaaaatcc  tccctggaa  acagaattt  cacttggag  ttggcctca  720
tattctctc  gtagtgttc  cagtatgtc  tttagcctg  ctgctggga  ttgctctcc  780
aaaatttaa  aggcgcaac  aagaacgcc  caatccccg  gacgtggag  atggcacta  840
cgaagggct  atcaccacc  atgttggag  cagcacttt  gcagattta  tggatcatt  900
gtgtacatc  ggaagtggc  ctggtcttc  ttttctggt  caaagaaca  tggctcgcc  960
gattacact  ttggagtgt  tcgggaaag  caggtatgg  gaggtgtgg  ggggcagct  1020
gcaagggga  aatgttgcc  tgaagatct  ctcctcccg  gatgagaag  catggttca  1080
ggaaacgga  ttgtacaac  ctgtgatgc  gaggcatga  aatatctta  gtttcattg  1140
ttcagacat  acatcaaga  actccagta  ccagctgtg  ttaattaca  attatcatg  1200
aatgggatc  ttgtacgac  atcttcagc  tactactct  gatacagtt  gctgccttc  1260
aatagtgct  tccatagct  gtggtcttg  acatttgca  atagagata  ttgggaccc  1320
agggaaacc  gccattgcc  atcgagatt  aaagagcaa  aatattctg  ttaagaaga  1380
tggacagtg  tgcatagca  atttgggcc  ggcagtcat  cattcccag  gcaccaatc  1440
gcttgatgt  gggaacaat  cccgtgtgg  caccaagcg  tacatggcc  ccgaagttc  1500
agatgaaac  atccaggtg  attgtttcg  ttcttataa  agggtcgat  tttgggcct  1560
tggacttgt  ttgtgggaa  tggccaggc  gatggtgag  aatggtata  tggaggatt  1620
caagccacc  ttctacgat  tggttccca  tgacccaag  tttgaagat  tgaggaagg  1680
agtctgtgt  gatcaacaa  ggccaaaca  acccaacag  tggttctca  acccgacat  1740
aacctctct  gccaagcta  tgaaagaat  ctggtatca  aatccatcc  caagactca  1800
agcactgcg  atcaaaaag  ctttgacca  aattgataa  tccctcgac  aattgaaaa  1860
tgactgttg  cattttcat  gtgtcaaga  ggaagattt  acgttgttg  cattgtcca  1920
ctgggacct  atgctggcc  gactggttg  cagaatgga  tccatctgt  tccctcccc  1980
aatggctgc  ttgacaagg  agacgtcgt  cccagccat  tgttgggga  acatcaaaa  2040
caccctaac  tcgctcgat  actgtgaac  gggcatttc  cgaactgtt  acactgcag  2100
gactaatgt  ggacagaca  tgttgcaaa  gtagggact  gaggaacac  gagaaatcc  2160
aaaagagat  tgggcatta  gtcagtggc  ttgcatagc  ttcacaagt  tcctagaca  2220
tccccacgg  aaactcaag  aggtggtga  tttttaatc  gcaatattg  ctgtgcttc  2280
cttctttat  gcactagga  ttctttgca  tccttactt  cactgttac  cttaatttt  2340
aagacccaa  ttgccaaaa  gttggctgc  tactccact  gtctgtctt  ggataatag  2400
aattcaatt  ggcaaaaca  aatgtaatg  cagactttg  tgcatttta  acatgtgct  2460
atgtttaca  tgatgccga  cattaggaa  tgtttatac  caactttgc  aattattta  2520
tacttgtgc  cttagtagt  tttacaaaa  tgctttgtg  atatgttaa  gcttatttt  2580
atgtggtct  atgatttta  tacagaaat  tttttaaca  tatactcta  aatggacat  2640
ttcttttat  atcagttaa  atcacattt  aagtgcttc  catttgtat  tgtgtagac  2700
gtaactttt  ttcagttca  atgcagaac  tatttagcc  ttacccacg  gacaccacc  2760
aatatatta  cgatttaga  gcaaagatt  cagtagaat  ttagtcctg  acgctacgg  2820
gaaaatgca  tttcttcag  attatccat  acgtgcatt  aaactctgc  agaaaaaaa  2880
aactatttt  ttttaatct  ctttttgta  ttagtagtt  tttgtataa  ttaaataaa  2940
tgttttcaa  tc  2952



<210> 2985
<211> 509
<212> PRT
<213> Homo sapiens
<308> Q04771
<400> 2985

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
  1               5                  10                  15
Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
             20                  25                  30
Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
         35                  40                  45
Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
     50                  55                  60
Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr 
 65                  70                  75                  80
Cys Lys Thr Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys Gln Gly 
                 85                  90                  95
Asp Trp Cys Asn Arg Asn Ile Thr Ala Gln Leu Pro Thr Lys Gly Lys 
             100                105                110
Ser Phe Pro Gly Thr Gln Asn Phe His Leu Glu Val Gly Leu Ile Ile 
         115                120                125
Leu Ser Val Val Phe Ala Val Cys Leu Leu Ala Cys Leu Leu Gly Val 
     130                135                140
Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn Pro Arg 
 145                150                155                160
Asp Val Glu Tyr Gly Thr Ile Glu Gly Leu Ile Thr Thr Asn Val Gly 
                 165                170                175
Asp Ser Thr Leu Ala Asp Leu Leu Asp His Ser Cys Thr Ser Gly Ser 
             180                185                190
Gly Ser Gly Leu Pro Phe Leu Val Gln Arg Thr Val Ala Arg Gln Ile 
         195                200                205
Thr Leu Leu Glu Cys Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
     210                215                220
Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys Ile Phe Ser Ser Arg 
 225                230                235                240
Asp Glu Lys Ser Trp Phe Arg Glu Thr Glu Leu Tyr Asn Thr Val Met 
                 245                250                255
Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Thr Ser 
             260                265                270
Arg His Ser Ser Thr Gln Leu Trp Leu Ile Thr His Tyr His Glu Met 
         275                280                285
Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Thr Thr Leu Asp Thr Val Ser 
     290                295                300
Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly Leu Ala His Leu His 
 305                310                315                320
Ile Glu Ile Phe Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                 325                330                335
Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Gln Cys Cys Ile 
             340                345                350
Ala Asp Leu Gly Leu Ala Val Met His Ser Gln Ser Thr Asn Gln Leu 
         355                360                365
Asp Val Gly Asn Asn Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
     370                375                380
Glu Val Leu Asp Glu Thr Ile Gln Val Asp Cys Phe Asp Ser Tyr Lys 
 385                390                395                400
Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Val Ala Arg 
                 405                410                415
Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr Lys Pro Pro Phe Tyr 
             420                425                430
Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Arg Lys Val Val 
         435                440                445
Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn Arg Trp Phe Ser Asp 
     450                455                460
Pro Thr Leu Thr Ser Leu Ala Lys Leu Met Lys Glu Cys Trp Tyr Gln 
 465                470                475                480
Asn Pro Ser Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Thr 
                 485                490                495
Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Thr Asp Cys 
             500                505



<210> 2986
<211> 2074
<212> DNA
<213> Rattus norvegicus
<308> L19699
<400> 2986

cggcggctc  ctcagctcc  catctgggc  atctgtccg  gtgtcgctg  ctcagacca  60
caggatggc  gccaacaaa  gcaagagcc  gggctccct  gtccttcac  aggtcatca  120
ggtcggcag  gggggagtc  gcaagtcag  cctgacgct  cagttcatg  atgacgagt  180
tgtagaaga  tatgagccc  ccaaagccg  cagttacag  aagaaggtg  ttctcgacg  240
agaagaggt  cagatagac  tcctggaca  agccggcca  gaggactat  cggccatcc  300
tgacaacta  ttccgaagc  gagaaggct  tctgctggt  ttctccatc  cggagcacg  360
gtctttcac  gccacagcc  agttcaggg  acagatcct  cgagtcaag  ccgaggagg  420
caaaatccc  ctgctggtc  tgggcaaca  gtctgacct  gaggagcgg  ggcaggtgc  480
cgtggagga  gcccgaggc  aagcggaag  gtggggtgt  cagtatgtg  agacatccg  540
aaagacccg  gccaacgtg  acaaggtgt  ctttgatct  atgagagaa  tccgggcaa  600
gaagatgtc  gaaaacaag  acaagaacg  caggaaaag  ggcaagagc  agaagagtt  660
caaagagcg  tgctgcttg  tgtgagcgg  ccgcggaca  agcgagcgg  gaaggccac  720
ttgcagcgc  ccgagccca  gtggcctcc  cctggctcc  cgtctccag  agctgtaat  780
cactatcac  tcttgaaga  ggacagata  ctgtgcaaa  cagtggctg  caggagaaa  840
acgcacttc  tctgtgcgt  tgtgcgatg  atctgctaa  gttgccagg  gctttgaga  900
tctgccccc  cccaccctc  ctgaaccgt  actgtcacc  gactctagg  tcaggaatc  960
gagttgtgt  gacaagaaa  aggattgcc  cggcggctt  tccccccct  ttctaggac  1020
tggtcatct  ttgttggaa  atcaaaatg  ttcacatta  cagggcgtg  tggtgcacc  1080
ctgtagtcc  agaactcta  aaggtaagg  agggagggt  gcctgagcc  aaggcccca  1140
ggcctgggc  acctagcaa  accctgtct  taaaaggaa  aagaactaa  atcttattt  1200
cttagattt  aaaagaggg  ctctggcaa  acccctcgt  agttcttat  agtttagaa  1260
tagacaggg  gcggaaaac  taagctcag  taatactga  aaagccaaa  caatttgtt  1320
ttttttttt  tttctgttt  aaaagataa  cttctgtga  ttggaagca  aattagaaa  1380
atgaacttc  cttggtcca  ataggctga  ccaagcctc  tggcgtttg  agagaagtg  1440
gacgctgtt  ccttcatac  taaatgcca  ccaggtgct  gctgtgggc  tccctccct  1500
acaccctta  ttagtagtg  ggaaacttt  tgtggggga  atgtagcct  tgccccaga  1560
caagctttc  tttttctga  tggatcatc  caccttttc  ggttccctc  cactccagc  1620
ataggcctg  tctttttct  cctttctga  aaatgtgac  agttcaaat  atgtcccag  1680
acacgggcc  gcgccagct  cctctgcag  ctctacaag  ggaagaggg  aaggctcag  1740
agggagggc  atctcctgt  gctcccggc  gttggttct  gtgacactg  catgaacca  1800
gttccagag  ctcacaccc  ctctctgtt  agcctcctc  cggggaagg  gactctggg  1860
ctgggggct  ccactgagc  cacacactc  tcccatttt  cagaagtga  catttcact  1920
ttggtgccg  atgtgaatc  gggtgggaa  agcgggagc  cttctaatg  atttttttt  1980
acagagtta  ggaatccaa  gtctgatcc  tggaaactt  tgtcacttc  aaagaatca  2040
gggcttttt  gaattaaaa  aaattacac  tttc  2074



<210> 2987
<211> 206
<212> PRT
<213> Rattus norvegicus
<308> P36860
<400> 2987

Met Ala Ala Asn Lys Gly Lys Ser Gln Gly Ser Leu Val Leu His Lys 
  1               5                  10                  15
Val Ile Met Val Gly Ser Gly Gly Val Gly Lys Ser Ala Leu Thr Leu 
             20                  25                  30
Gln Phe Met Tyr Asp Glu Phe Val Glu Asp Tyr Glu Pro Thr Lys Ala 
         35                  40                  45
Asp Ser Tyr Arg Lys Lys Val Val Leu Asp Gly Glu Glu Val Gln Ile 
     50                  55                  60
Asp Ile Leu Asp Thr Ala Gly Gln Glu Asp Tyr Ala Ala Ile Arg Asp 
 65                  70                  75                  80
Asn Tyr Phe Arg Ser Gly Glu Gly Phe Leu Leu Val Phe Ser Ile Thr 
                 85                  90                  95
Glu His Glu Ser Phe Thr Ala Thr Ala Glu Phe Arg Glu Gln Ile Leu 
             100                105                110
Arg Val Lys Ala Glu Glu Asp Lys Ile Pro Leu Leu Val Val Gly Asn 
         115                120                125
Lys Ser Asp Leu Glu Glu Arg Arg Gln Val Pro Val Glu Glu Ala Arg 
     130                135                140
Gly Lys Ala Glu Glu Trp Gly Val Gln Tyr Val Glu Thr Ser Ala Lys 
 145                150                155                160
Thr Arg Ala Asn Val Asp Lys Val Phe Phe Asp Leu Met Arg Glu Ile 
                 165                170                175
Arg Ala Lys Lys Met Ser Glu Asn Lys Asp Lys Asn Gly Arg Lys Ser 
             180                185                190
Gly Lys Ser Lys Lys Ser Phe Lys Glu Arg Cys Cys Leu Leu 
         195                200                205



<210> 2988
<211> 1327
<212> DNA
<213> Homo sapiens
<308> M35416
<400> 2988

gagcccggc  gctcaatga  aaatcggtg  aggacggct  gggtccggc  ccgggaggg  60
ccggggcgc  tttaagagc  gcgggccgg  tgcggacgg  ggaggcggc  ggactggtc  120
ctgctcttc  gtgggtcat  tgtgtgtca  agcctcaga  gaccagcga  atggctgcc  180
acaagagta  gggccagag  tccttggcc  tccacaagg  gatcatggt  ggcagcgga  240
gcgttggca  gtcagccct  acgcttcag  tcatgtatg  cgagtttgt  gaagactat  300
aacctacca  agctgacag  tatagaaag  aagtggttc  tgatgggga  gaagttcag  360
tagatattc  ggacaccgc  gggcaagag  actacgcag  cattcgaga  aactacttt  420
ggagtgggg  agggtttct  cttgtgttc  caatcacag  acatgaatc  tttacagca  480
ctgccgaat  cagggaaca  attctccgt  tgaaggctg  agaagataa  attccactg  540
tcgtcgtgg  aaacaagtc  gacctagag  agcggaggc  ggtgcctgt  gaggaggcc  600
ggagtaaag  cgaagagtg  ggcgtgcag  acgtggaga  gtcagcgaa  acccgggcc  660
acgtggaca  ggtgttctt  gacctaatg  gagaaatca  aacaaagaa  atgtcagaa  720
acaaagaca  gaatggcaa  aaaagcagc  agaacaaga  aagttttaa  gaaagatgt  780
gcttactat  agtgtcaag  tgacggatg  agccagctg  tcctaagga  acagggctg  840
gttggtaaa  agaaggcta  ggttgactt  ttgcttgtg  ttcccactc  ccccgactt  900
attcactca  acttcttta  atggggaaa  atatttgtg  ctctgtggc  ggcagaaga  960
ataagccca  gcaagtgga  gggctgctt  gtcaggagg  tgtggaatt  ctttcttct  1020
cccttcttc  ctcccaaaa  cttagctat  tataaagtg  cacagatag  aaacagctg  1080
taattacaa  gagaaagaa  tgtcatagc  tcttatttt  ttcctagtt  tataacatt  1140
ccatccttc  ttttgaact  cagatgttg  agtgggttt  ggaggaggg  gtggagtaa  1200
atgccctcc  acttttatc  gtttagtag  agtactgag  aaaatccct  cagctctaa  1260
aacactgaa  aatccaccg  ttttttggg  aagcttctt  gcaataccc  gtggatctg  1320
aacagct  1327



<210> 2989
<211> 206
<212> PRT
<213> Homo sapiens
<308> P11234
<400> 2989

Met Ala Ala Asn Lys Ser Lys Gly Gln Ser Ser Leu Ala Leu His Lys 
  1               5                  10                  15
Val Ile Met Val Gly Ser Gly Gly Val Gly Lys Ser Ala Leu Thr Leu 
             20                  25                  30
Gln Phe Met Tyr Asp Glu Phe Val Glu Asp Tyr Glu Pro Thr Lys Ala 
         35                  40                  45
Asp Ser Tyr Arg Lys Lys Val Val Leu Asp Gly Glu Glu Val Gln Ile 
     50                  55                  60
Asp Ile Leu Asp Thr Ala Gly Gln Glu Asp Tyr Ala Ala Ile Arg Asp 
 65                  70                  75                  80
Asn Tyr Phe Arg Ser Gly Glu Gly Phe Leu Leu Val Phe Ser Ile Thr 
                 85                  90                  95
Glu His Glu Ser Phe Thr Ala Thr Ala Glu Phe Arg Glu Gln Ile Leu 
             100                105                110
Arg Val Lys Ala Glu Glu Asp Lys Ile Pro Leu Leu Val Val Gly Asn 
         115                120                125
Lys Ser Asp Leu Glu Glu Arg Arg Gln Val Pro Val Glu Glu Ala Arg 
     130                135                140
Ser Lys Ala Glu Glu Trp Gly Val Gln Tyr Val Glu Thr Ser Ala Lys 
 145                150                155                160
Thr Arg Ala Asn Val Asp Lys Val Phe Phe Asp Leu Met Arg Glu Ile 
                 165                170                175
Arg Thr Lys Lys Met Ser Glu Asn Lys Asp Lys Asn Gly Lys Lys Ser 
             180                185                190
Ser Lys Asn Lys Lys Ser Phe Lys Glu Arg Cys Cys Leu Leu 
         195                200                205



<210> 2990
<211> 2074
<212> DNA
<213> Rattus norvegicus
<308> L19699
<400> 2990

cggcggctc  ctcagctcc  catctgggc  atctgtccg  gtgtcgctg  ctcagacca  60
caggatggc  gccaacaaa  gcaagagcc  gggctccct  gtccttcac  aggtcatca  120
ggtcggcag  gggggagtc  gcaagtcag  cctgacgct  cagttcatg  atgacgagt  180
tgtagaaga  tatgagccc  ccaaagccg  cagttacag  aagaaggtg  ttctcgacg  240
agaagaggt  cagatagac  tcctggaca  agccggcca  gaggactat  cggccatcc  300
tgacaacta  ttccgaagc  gagaaggct  tctgctggt  ttctccatc  cggagcacg  360
gtctttcac  gccacagcc  agttcaggg  acagatcct  cgagtcaag  ccgaggagg  420
caaaatccc  ctgctggtc  tgggcaaca  gtctgacct  gaggagcgg  ggcaggtgc  480
cgtggagga  gcccgaggc  aagcggaag  gtggggtgt  cagtatgtg  agacatccg  540
aaagacccg  gccaacgtg  acaaggtgt  ctttgatct  atgagagaa  tccgggcaa  600
gaagatgtc  gaaaacaag  acaagaacg  caggaaaag  ggcaagagc  agaagagtt  660
caaagagcg  tgctgcttg  tgtgagcgg  ccgcggaca  agcgagcgg  gaaggccac  720
ttgcagcgc  ccgagccca  gtggcctcc  cctggctcc  cgtctccag  agctgtaat  780
cactatcac  tcttgaaga  ggacagata  ctgtgcaaa  cagtggctg  caggagaaa  840
acgcacttc  tctgtgcgt  tgtgcgatg  atctgctaa  gttgccagg  gctttgaga  900
tctgccccc  cccaccctc  ctgaaccgt  actgtcacc  gactctagg  tcaggaatc  960
gagttgtgt  gacaagaaa  aggattgcc  cggcggctt  tccccccct  ttctaggac  1020
tggtcatct  ttgttggaa  atcaaaatg  ttcacatta  cagggcgtg  tggtgcacc  1080
ctgtagtcc  agaactcta  aaggtaagg  agggagggt  gcctgagcc  aaggcccca  1140
ggcctgggc  acctagcaa  accctgtct  taaaaggaa  aagaactaa  atcttattt  1200
cttagattt  aaaagaggg  ctctggcaa  acccctcgt  agttcttat  agtttagaa  1260
tagacaggg  gcggaaaac  taagctcag  taatactga  aaagccaaa  caatttgtt  1320
ttttttttt  tttctgttt  aaaagataa  cttctgtga  ttggaagca  aattagaaa  1380
atgaacttc  cttggtcca  ataggctga  ccaagcctc  tggcgtttg  agagaagtg  1440
gacgctgtt  ccttcatac  taaatgcca  ccaggtgct  gctgtgggc  tccctccct  1500
acaccctta  ttagtagtg  ggaaacttt  tgtggggga  atgtagcct  tgccccaga  1560
caagctttc  tttttctga  tggatcatc  caccttttc  ggttccctc  cactccagc  1620
ataggcctg  tctttttct  cctttctga  aaatgtgac  agttcaaat  atgtcccag  1680
acacgggcc  gcgccagct  cctctgcag  ctctacaag  ggaagaggg  aaggctcag  1740
agggagggc  atctcctgt  gctcccggc  gttggttct  gtgacactg  catgaacca  1800
gttccagag  ctcacaccc  ctctctgtt  agcctcctc  cggggaagg  gactctggg  1860
ctgggggct  ccactgagc  cacacactc  tcccatttt  cagaagtga  catttcact  1920
ttggtgccg  atgtgaatc  gggtgggaa  agcgggagc  cttctaatg  atttttttt  1980
acagagtta  ggaatccaa  gtctgatcc  tggaaactt  tgtcacttc  aaagaatca  2040
gggcttttt  gaattaaaa  aaattacac  tttc  2074



<210> 2991
<211> 206
<212> PRT
<213> Rattus norvegicus
<308> P36860
<400> 2991

Met Ala Ala Asn Lys Gly Lys Ser Gln Gly Ser Leu Val Leu His Lys 
  1               5                  10                  15
Val Ile Met Val Gly Ser Gly Gly Val Gly Lys Ser Ala Leu Thr Leu 
             20                  25                  30
Gln Phe Met Tyr Asp Glu Phe Val Glu Asp Tyr Glu Pro Thr Lys Ala 
         35                  40                  45
Asp Ser Tyr Arg Lys Lys Val Val Leu Asp Gly Glu Glu Val Gln Ile 
     50                  55                  60
Asp Ile Leu Asp Thr Ala Gly Gln Glu Asp Tyr Ala Ala Ile Arg Asp 
 65                  70                  75                  80
Asn Tyr Phe Arg Ser Gly Glu Gly Phe Leu Leu Val Phe Ser Ile Thr 
                 85                  90                  95
Glu His Glu Ser Phe Thr Ala Thr Ala Glu Phe Arg Glu Gln Ile Leu 
             100                105                110
Arg Val Lys Ala Glu Glu Asp Lys Ile Pro Leu Leu Val Val Gly Asn 
         115                120                125
Lys Ser Asp Leu Glu Glu Arg Arg Gln Val Pro Val Glu Glu Ala Arg 
     130                135                140
Gly Lys Ala Glu Glu Trp Gly Val Gln Tyr Val Glu Thr Ser Ala Lys 
 145                150                155                160
Thr Arg Ala Asn Val Asp Lys Val Phe Phe Asp Leu Met Arg Glu Ile 
                 165                170                175
Arg Ala Lys Lys Met Ser Glu Asn Lys Asp Lys Asn Gly Arg Lys Ser 
             180                185                190
Gly Lys Ser Lys Lys Ser Phe Lys Glu Arg Cys Cys Leu Leu 
         195                200                205



<210> 2992
<211> 1327
<212> DNA
<213> Homo sapiens
<308> M35416
<400> 2992

gagcccggc  gctcaatga  aaatcggtg  aggacggct  gggtccggc  ccgggaggg  60
ccggggcgc  tttaagagc  gcgggccgg  tgcggacgg  ggaggcggc  ggactggtc  120
ctgctcttc  gtgggtcat  tgtgtgtca  agcctcaga  gaccagcga  atggctgcc  180
acaagagta  gggccagag  tccttggcc  tccacaagg  gatcatggt  ggcagcgga  240
gcgttggca  gtcagccct  acgcttcag  tcatgtatg  cgagtttgt  gaagactat  300
aacctacca  agctgacag  tatagaaag  aagtggttc  tgatgggga  gaagttcag  360
tagatattc  ggacaccgc  gggcaagag  actacgcag  cattcgaga  aactacttt  420
ggagtgggg  agggtttct  cttgtgttc  caatcacag  acatgaatc  tttacagca  480
ctgccgaat  cagggaaca  attctccgt  tgaaggctg  agaagataa  attccactg  540
tcgtcgtgg  aaacaagtc  gacctagag  agcggaggc  ggtgcctgt  gaggaggcc  600
ggagtaaag  cgaagagtg  ggcgtgcag  acgtggaga  gtcagcgaa  acccgggcc  660
acgtggaca  ggtgttctt  gacctaatg  gagaaatca  aacaaagaa  atgtcagaa  720
acaaagaca  gaatggcaa  aaaagcagc  agaacaaga  aagttttaa  gaaagatgt  780
gcttactat  agtgtcaag  tgacggatg  agccagctg  tcctaagga  acagggctg  840
gttggtaaa  agaaggcta  ggttgactt  ttgcttgtg  ttcccactc  ccccgactt  900
attcactca  acttcttta  atggggaaa  atatttgtg  ctctgtggc  ggcagaaga  960
ataagccca  gcaagtgga  gggctgctt  gtcaggagg  tgtggaatt  ctttcttct  1020
cccttcttc  ctcccaaaa  cttagctat  tataaagtg  cacagatag  aaacagctg  1080
taattacaa  gagaaagaa  tgtcatagc  tcttatttt  ttcctagtt  tataacatt  1140
ccatccttc  ttttgaact  cagatgttg  agtgggttt  ggaggaggg  gtggagtaa  1200
atgccctcc  acttttatc  gtttagtag  agtactgag  aaaatccct  cagctctaa  1260
aacactgaa  aatccaccg  ttttttggg  aagcttctt  gcaataccc  gtggatctg  1320
aacagct  1327



<210> 2993
<211> 206
<212> PRT
<213> Homo sapiens
<308> P11234
<400> 2993

Met Ala Ala Asn Lys Ser Lys Gly Gln Ser Ser Leu Ala Leu His Lys 
  1               5                  10                  15
Val Ile Met Val Gly Ser Gly Gly Val Gly Lys Ser Ala Leu Thr Leu 
             20                  25                  30
Gln Phe Met Tyr Asp Glu Phe Val Glu Asp Tyr Glu Pro Thr Lys Ala 
         35                  40                  45
Asp Ser Tyr Arg Lys Lys Val Val Leu Asp Gly Glu Glu Val Gln Ile 
     50                  55                  60
Asp Ile Leu Asp Thr Ala Gly Gln Glu Asp Tyr Ala Ala Ile Arg Asp 
 65                  70                  75                  80
Asn Tyr Phe Arg Ser Gly Glu Gly Phe Leu Leu Val Phe Ser Ile Thr 
                 85                  90                  95
Glu His Glu Ser Phe Thr Ala Thr Ala Glu Phe Arg Glu Gln Ile Leu 
             100                105                110
Arg Val Lys Ala Glu Glu Asp Lys Ile Pro Leu Leu Val Val Gly Asn 
         115                120                125
Lys Ser Asp Leu Glu Glu Arg Arg Gln Val Pro Val Glu Glu Ala Arg 
     130                135                140
Ser Lys Ala Glu Glu Trp Gly Val Gln Tyr Val Glu Thr Ser Ala Lys 
 145                150                155                160
Thr Arg Ala Asn Val Asp Lys Val Phe Phe Asp Leu Met Arg Glu Ile 
                 165                170                175
Arg Thr Lys Lys Met Ser Glu Asn Lys Asp Lys Asn Gly Lys Lys Ser 
             180                185                190
Ser Lys Asn Lys Lys Ser Phe Lys Glu Arg Cys Cys Leu Leu 
         195                200                205



<210> 2994
<211> 1227
<212> DNA
<213> Rattus norvegicus
<308> L19998
<400> 2994

ggaattcgc  acgcctaca  aaagatccc  atcactgag  acccggagg  aaggctcag  60
accccagga  cagcaacat  gagttctcc  gtccaccgc  agtgcatgt  aagggtatc  120
cactcatca  atactttgc  gagacaatt  ggccattgc  gaacttcac  gcctggcct  180
atgacttgc  gatcagcac  tacccaaag  ctggtacta  ctggatgag  gagatcctg  240
atatgatct  tcagggtgg  aagctagag  agtgtggcc  cgcccccat  tatgcccgg  300
tacccttcc  tgagttcaa  tgtccaggg  ttccctcag  tcttgaaac  ttggaagag  360
caccagccc  acggctcct  aagacacat  tgcccctgt  cttgctccc  cagagtctg  420
tggatcaga  ggtcaaggt  atctacatt  cccgaaatg  aaaggatgt  gttgtctcc  480
attataact  ctacaacat  gccaagctg  accctgatc  aggcacctg  gacagcttc  540
tggagaact  catggatgg  gaagtgtcc  atgggtcgt  gtaccagca  gtgaaggag  600
ggtgggagc  gagacacac  caccctgtt  tctatctct  ctatgaaga  ataaaggag  660
accccaaaa  ggagatcaa  aagattcta  agtttttgg  gcgctctct  cccgaggag  720
ctgtggatt  cattgttca  cacacatct  tcaagaaaa  gaaagagaa  tgcatgact  780
actacacaa  catccccac  gagattatg  accacaatg  ttctccctt  atgaggaaa  840
gtactactg  ggactggaa  aataccttc  ctgtagccc  gaatgagcg  tttgatgcc  900
actatgcta  gacaatgac  gattgtgac  tcaagtttc  ttgtgaact  tgagtggat  960
atggctata  tgggaacca  ggcaaactg  cacagccca  catgatctc  agtaaaatg  1020
gatgtgttc  atctacttg  tgtatgcct  gaggaaatc  gagctaaga  aataggatt  1080
gggatgtgg  tgaggcaga  ggttttatc  acgcatgtc  ggaaagcaa  cagtcccaa  1140
acctaaaaa  aacctaaag  acaaacatg  aaaaaatag  aagataaac  atattttac  1200
tgaaagaat  aatgccact  ggaaatg  1227



<210> 2995
<211> 291
<212> PRT
<213> Rattus norvegicus
<308> P17988
<400> 2995

Met Glu Phe Ser Arg Pro Pro Leu Val His Val Lys Gly Ile Pro Leu 
  1               5                  10                  15
Ile Lys Tyr Phe Ala Glu Thr Ile Gly Pro Leu Gln Asn Phe Thr Ala 
             20                  25                  30
Trp Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys Ser Gly Thr Thr 
         35                  40                  45
Trp Met Ser Glu Ile Leu Asp Met Ile Tyr Gln Gly Gly Lys Leu Glu 
     50                  55                  60
Lys Cys Gly Arg Ala Pro Ile Tyr Ala Arg Val Pro Phe Leu Glu Phe 
 65                  70                  75                  80
Lys Cys Pro Gly Val Pro Ser Gly Leu Glu Thr Leu Glu Glu Thr Pro 
                 85                  90                  95
Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ser Leu Leu Pro Gln 
             100                105                110
Ser Leu Leu Asp Gln Lys Val Lys Val Ile Tyr Ile Ala Arg Asn Ala 
         115                120                125
Lys Asp Val Val Val Ser Tyr Tyr Asn Phe Tyr Asn Met Ala Lys Leu 
     130                135                140
His Pro Asp Pro Gly Thr Trp Asp Ser Phe Leu Glu Asn Phe Met Asp 
 145                150                155                160
Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val Lys Glu Trp Trp 
                 165                170                175
Glu Leu Arg His Thr His Pro Val Leu Tyr Leu Phe Tyr Glu Asp Ile 
             180                185                190
Lys Glu Asn Pro Lys Arg Glu Ile Lys Lys Ile Leu Glu Phe Leu Gly 
         195                200                205
Arg Ser Leu Pro Glu Glu Thr Val Asp Ser Ile Val His His Thr Ser 
     210                215                220
Phe Lys Lys Met Lys Glu Asn Cys Met Thr Asn Tyr Thr Thr Ile Pro 
 225                230                235                240
Thr Glu Ile Met Asp His Asn Val Ser Pro Phe Met Arg Lys Gly Thr 
                 245                250                255
Thr Gly Asp Trp Lys Asn Thr Phe Thr Val Ala Gln Asn Glu Arg Phe 
             260                265                270
Asp Ala His Tyr Ala Lys Thr Met Thr Asp Cys Asp Phe Lys Phe Arg 
         275                280                285
Cys Glu Leu 
     290



<210> 2996
<211> 1176
<212> DNA
<213> Homo sapiens
<308> L19999
<400> 2996

cacacagca  ccacaatca  ccactgcgg  cgaggaggg  acgaggcca  gttcccaag  60
gctcaggaa  atggagctg  tccaggaca  ctcccgccc  ccactggag  acgtgaagg  120
ggtcccgct  atcaagtac  ttgcagagg  actggggcc  ctgcagagc  tccaggccc  180
gcctgatga  ctgctcatc  gcacctacc  caagtccgg  actacctgg  taagccaga  240
tctggacat  atctaccag  gtggtgacc  ggagaagtg  caccgagct  ccatcttca  300
gcgggtgcc  ttccttgag  tcaaagccc  agggattcc  tcagggatg  agactctga  360
agacacacc  gccccacga  tcctgaaga  acacctgcc  ctggctctg  tcccccaga  420
tctgttgga  cagaaggtc  aggtggtct  tgttgcccg  aacgcaaag  atgtggcag  480
ttcctacta  cacttctac  acatggcca  ggtgcaccc  gagcctggg  cctgggaca  540
cttcctgga  aagttcatg  tcggagaag  gtcctacgg  tcctggtac  agcacgtgc  600
ggagtggtg  gagctgagc  gcacccacc  tgttctcta  ctcttctat  aagacatga  660
ggagaaccc  aaaagggag  ttcaaaaga  cctggagtt  gtggggcgc  ccctgccag  720
ggagaccgt  gacttcatg  ttcagcaca  gtcgttcaa  gagatgaag  agaacccta  780
gaccaacta  accaccgtc  cccaggagt  catggacca  agcatctcc  ccttcatga  840
gaaaggcat  gctggggac  ggaagacca  cttcaccgt  gcgcagaat  agcgcttcg  900
tgcggacta  gcgaagaag  tggcaggct  cagcctcac  ttccgctct  agctgtgag  960
ggggctcct  gagtcactg  agagggagt  tgcgaatca  acctgacca  gcggctcaa  1020
aataaaata  caattgagg  cccggacgg  aggtcatgt  tgtaatccc  gcaatttgg  1080
ggctgaggt  ggaggatca  ttgagccca  gagttcgag  ccaacctgg  caacatagt  1140
agattctgt  aaaaaaata  aataaaata  aaccaa  1176



<210> 2997
<211> 295
<212> PRT
<213> Homo sapiens
<308> P50225
<400> 2997

Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys 
  1               5                  10                  15
Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
             20                  25                  30
Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys 
         35                  40                  45
Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
     50                  55                  60
Gly Asp Leu Glu Lys Cys His Arg Ala Pro Ile Phe Met Arg Val Pro 
 65                  70                  75                  80
Phe Leu Glu Phe Lys Ala Pro Gly Ile Pro Ser Gly Met Glu Thr Leu 
                 85                  90                  95
Lys Asp Thr Pro Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ala 
             100                105                110
Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
         115                120                125
Ala Arg Asn Ala Lys Asp Val Ala Val Ser Tyr Tyr His Phe Tyr His 
     130                135                140
Met Ala Lys Val His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu 
 145                150                155                160
Lys Phe Met Val Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                 165                170                175
Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
             180                185                190
Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
         195                200                205
Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Val Asp Phe Met Val 
     210                215                220
Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
 225                230                235                240
Thr Thr Val Pro Gln Glu Phe Met Asp His Ser Ile Ser Pro Phe Met 
                 245                250                255
Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
             260                265                270
Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
         275                280                285
Leu Ser Phe Arg Ser Glu Leu 
     290                295



<210> 2998
<211> 1227
<212> DNA
<213> Rattus norvegicus
<308> L19998
<400> 2998

ggaattcgc  acgcctaca  aaagatccc  atcactgag  acccggagg  aaggctcag  60
accccagga  cagcaacat  gagttctcc  gtccaccgc  agtgcatgt  aagggtatc  120
cactcatca  atactttgc  gagacaatt  ggccattgc  gaacttcac  gcctggcct  180
atgacttgc  gatcagcac  tacccaaag  ctggtacta  ctggatgag  gagatcctg  240
atatgatct  tcagggtgg  aagctagag  agtgtggcc  cgcccccat  tatgcccgg  300
tacccttcc  tgagttcaa  tgtccaggg  ttccctcag  tcttgaaac  ttggaagag  360
caccagccc  acggctcct  aagacacat  tgcccctgt  cttgctccc  cagagtctg  420
tggatcaga  ggtcaaggt  atctacatt  cccgaaatg  aaaggatgt  gttgtctcc  480
attataact  ctacaacat  gccaagctg  accctgatc  aggcacctg  gacagcttc  540
tggagaact  catggatgg  gaagtgtcc  atgggtcgt  gtaccagca  gtgaaggag  600
ggtgggagc  gagacacac  caccctgtt  tctatctct  ctatgaaga  ataaaggag  660
accccaaaa  ggagatcaa  aagattcta  agtttttgg  gcgctctct  cccgaggag  720
ctgtggatt  cattgttca  cacacatct  tcaagaaaa  gaaagagaa  tgcatgact  780
actacacaa  catccccac  gagattatg  accacaatg  ttctccctt  atgaggaaa  840
gtactactg  ggactggaa  aataccttc  ctgtagccc  gaatgagcg  tttgatgcc  900
actatgcta  gacaatgac  gattgtgac  tcaagtttc  ttgtgaact  tgagtggat  960
atggctata  tgggaacca  ggcaaactg  cacagccca  catgatctc  agtaaaatg  1020
gatgtgttc  atctacttg  tgtatgcct  gaggaaatc  gagctaaga  aataggatt  1080
gggatgtgg  tgaggcaga  ggttttatc  acgcatgtc  ggaaagcaa  cagtcccaa  1140
acctaaaaa  aacctaaag  acaaacatg  aaaaaatag  aagataaac  atattttac  1200
tgaaagaat  aatgccact  ggaaatg  1227



<210> 2999
<211> 291
<212> PRT
<213> Rattus norvegicus
<308> P17988
<400> 2999

Met Glu Phe Ser Arg Pro Pro Leu Val His Val Lys Gly Ile Pro Leu 
  1               5                  10                  15
Ile Lys Tyr Phe Ala Glu Thr Ile Gly Pro Leu Gln Asn Phe Thr Ala 
             20                  25                  30
Trp Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys Ser Gly Thr Thr 
         35                  40                  45
Trp Met Ser Glu Ile Leu Asp Met Ile Tyr Gln Gly Gly Lys Leu Glu 
     50                  55                  60
Lys Cys Gly Arg Ala Pro Ile Tyr Ala Arg Val Pro Phe Leu Glu Phe 
 65                  70                  75                  80
Lys Cys Pro Gly Val Pro Ser Gly Leu Glu Thr Leu Glu Glu Thr Pro 
                 85                  90                  95
Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ser Leu Leu Pro Gln 
             100                105                110
Ser Leu Leu Asp Gln Lys Val Lys Val Ile Tyr Ile Ala Arg Asn Ala 
         115                120                125
Lys Asp Val Val Val Ser Tyr Tyr Asn Phe Tyr Asn Met Ala Lys Leu 
     130                135                140
His Pro Asp Pro Gly Thr Trp Asp Ser Phe Leu Glu Asn Phe Met Asp 
 145                150                155                160
Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val Lys Glu Trp Trp 
                 165                170                175
Glu Leu Arg His Thr His Pro Val Leu Tyr Leu Phe Tyr Glu Asp Ile 
             180                185                190
Lys Glu Asn Pro Lys Arg Glu Ile Lys Lys Ile Leu Glu Phe Leu Gly 
         195                200                205
Arg Ser Leu Pro Glu Glu Thr Val Asp Ser Ile Val His His Thr Ser 
     210                215                220
Phe Lys Lys Met Lys Glu Asn Cys Met Thr Asn Tyr Thr Thr Ile Pro 
 225                230                235                240
Thr Glu Ile Met Asp His Asn Val Ser Pro Phe Met Arg Lys Gly Thr 
                 245                250                255
Thr Gly Asp Trp Lys Asn Thr Phe Thr Val Ala Gln Asn Glu Arg Phe 
             260                265                270
Asp Ala His Tyr Ala Lys Thr Met Thr Asp Cys Asp Phe Lys Phe Arg 
         275                280                285
Cys Glu Leu 
     290



<210> 3000
<211> 1176
<212> DNA
<213> Homo sapiens
<308> L19999
<400> 3000

cacacagca  ccacaatca  ccactgcgg  cgaggaggg  acgaggcca  gttcccaag  60
gctcaggaa  atggagctg  tccaggaca  ctcccgccc  ccactggag  acgtgaagg  120
ggtcccgct  atcaagtac  ttgcagagg  actggggcc  ctgcagagc  tccaggccc  180
gcctgatga  ctgctcatc  gcacctacc  caagtccgg  actacctgg  taagccaga  240
tctggacat  atctaccag  gtggtgacc  ggagaagtg  caccgagct  ccatcttca  300
gcgggtgcc  ttccttgag  tcaaagccc  agggattcc  tcagggatg  agactctga  360
agacacacc  gccccacga  tcctgaaga  acacctgcc  ctggctctg  tcccccaga  420
tctgttgga  cagaaggtc  aggtggtct  tgttgcccg  aacgcaaag  atgtggcag  480
ttcctacta  cacttctac  acatggcca  ggtgcaccc  gagcctggg  cctgggaca  540
cttcctgga  aagttcatg  tcggagaag  gtcctacgg  tcctggtac  agcacgtgc  600
ggagtggtg  gagctgagc  gcacccacc  tgttctcta  ctcttctat  aagacatga  660
ggagaaccc  aaaagggag  ttcaaaaga  cctggagtt  gtggggcgc  ccctgccag  720
ggagaccgt  gacttcatg  ttcagcaca  gtcgttcaa  gagatgaag  agaacccta  780
gaccaacta  accaccgtc  cccaggagt  catggacca  agcatctcc  ccttcatga  840
gaaaggcat  gctggggac  ggaagacca  cttcaccgt  gcgcagaat  agcgcttcg  900
tgcggacta  gcgaagaag  tggcaggct  cagcctcac  ttccgctct  agctgtgag  960
ggggctcct  gagtcactg  agagggagt  tgcgaatca  acctgacca  gcggctcaa  1020
aataaaata  caattgagg  cccggacgg  aggtcatgt  tgtaatccc  gcaatttgg  1080
ggctgaggt  ggaggatca  ttgagccca  gagttcgag  ccaacctgg  caacatagt  1140
agattctgt  aaaaaaata  aataaaata  aaccaa  1176



<210> 3001
<211> 295
<212> PRT
<213> Homo sapiens
<308> P50225
<400> 3001

Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys 
  1               5                  10                  15
Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
             20                  25                  30
Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys 
         35                  40                  45
Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
     50                  55                  60
Gly Asp Leu Glu Lys Cys His Arg Ala Pro Ile Phe Met Arg Val Pro 
 65                  70                  75                  80
Phe Leu Glu Phe Lys Ala Pro Gly Ile Pro Ser Gly Met Glu Thr Leu 
                 85                  90                  95
Lys Asp Thr Pro Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ala 
             100                105                110
Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
         115                120                125
Ala Arg Asn Ala Lys Asp Val Ala Val Ser Tyr Tyr His Phe Tyr His 
     130                135                140
Met Ala Lys Val His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu 
 145                150                155                160
Lys Phe Met Val Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                 165                170                175
Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
             180                185                190
Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
         195                200                205
Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Val Asp Phe Met Val 
     210                215                220
Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
 225                230                235                240
Thr Thr Val Pro Gln Glu Phe Met Asp His Ser Ile Ser Pro Phe Met 
                 245                250                255
Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
             260                265                270
Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
         275                280                285
Leu Ser Phe Arg Ser Glu Leu 
     290                295



<210> 3002
<211> 1227
<212> DNA
<213> Rattus norvegicus
<308> L19998
<400> 3002

ggaattcgc  acgcctaca  aaagatccc  atcactgag  acccggagg  aaggctcag  60
accccagga  cagcaacat  gagttctcc  gtccaccgc  agtgcatgt  aagggtatc  120
cactcatca  atactttgc  gagacaatt  ggccattgc  gaacttcac  gcctggcct  180
atgacttgc  gatcagcac  tacccaaag  ctggtacta  ctggatgag  gagatcctg  240
atatgatct  tcagggtgg  aagctagag  agtgtggcc  cgcccccat  tatgcccgg  300
tacccttcc  tgagttcaa  tgtccaggg  ttccctcag  tcttgaaac  ttggaagag  360
caccagccc  acggctcct  aagacacat  tgcccctgt  cttgctccc  cagagtctg  420
tggatcaga  ggtcaaggt  atctacatt  cccgaaatg  aaaggatgt  gttgtctcc  480
attataact  ctacaacat  gccaagctg  accctgatc  aggcacctg  gacagcttc  540
tggagaact  catggatgg  gaagtgtcc  atgggtcgt  gtaccagca  gtgaaggag  600
ggtgggagc  gagacacac  caccctgtt  tctatctct  ctatgaaga  ataaaggag  660
accccaaaa  ggagatcaa  aagattcta  agtttttgg  gcgctctct  cccgaggag  720
ctgtggatt  cattgttca  cacacatct  tcaagaaaa  gaaagagaa  tgcatgact  780
actacacaa  catccccac  gagattatg  accacaatg  ttctccctt  atgaggaaa  840
gtactactg  ggactggaa  aataccttc  ctgtagccc  gaatgagcg  tttgatgcc  900
actatgcta  gacaatgac  gattgtgac  tcaagtttc  ttgtgaact  tgagtggat  960
atggctata  tgggaacca  ggcaaactg  cacagccca  catgatctc  agtaaaatg  1020
gatgtgttc  atctacttg  tgtatgcct  gaggaaatc  gagctaaga  aataggatt  1080
gggatgtgg  tgaggcaga  ggttttatc  acgcatgtc  ggaaagcaa  cagtcccaa  1140
acctaaaaa  aacctaaag  acaaacatg  aaaaaatag  aagataaac  atattttac  1200
tgaaagaat  aatgccact  ggaaatg  1227



<210> 3003
<211> 291
<212> PRT
<213> Rattus norvegicus
<308> P17988
<400> 3003

Met Glu Phe Ser Arg Pro Pro Leu Val His Val Lys Gly Ile Pro Leu 
  1               5                  10                  15
Ile Lys Tyr Phe Ala Glu Thr Ile Gly Pro Leu Gln Asn Phe Thr Ala 
             20                  25                  30
Trp Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys Ser Gly Thr Thr 
         35                  40                  45
Trp Met Ser Glu Ile Leu Asp Met Ile Tyr Gln Gly Gly Lys Leu Glu 
     50                  55                  60
Lys Cys Gly Arg Ala Pro Ile Tyr Ala Arg Val Pro Phe Leu Glu Phe 
 65                  70                  75                  80
Lys Cys Pro Gly Val Pro Ser Gly Leu Glu Thr Leu Glu Glu Thr Pro 
                 85                  90                  95
Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ser Leu Leu Pro Gln 
             100                105                110
Ser Leu Leu Asp Gln Lys Val Lys Val Ile Tyr Ile Ala Arg Asn Ala 
         115                120                125
Lys Asp Val Val Val Ser Tyr Tyr Asn Phe Tyr Asn Met Ala Lys Leu 
     130                135                140
His Pro Asp Pro Gly Thr Trp Asp Ser Phe Leu Glu Asn Phe Met Asp 
 145                150                155                160
Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val Lys Glu Trp Trp 
                 165                170                175
Glu Leu Arg His Thr His Pro Val Leu Tyr Leu Phe Tyr Glu Asp Ile 
             180                185                190
Lys Glu Asn Pro Lys Arg Glu Ile Lys Lys Ile Leu Glu Phe Leu Gly 
         195                200                205
Arg Ser Leu Pro Glu Glu Thr Val Asp Ser Ile Val His His Thr Ser 
     210                215                220
Phe Lys Lys Met Lys Glu Asn Cys Met Thr Asn Tyr Thr Thr Ile Pro 
 225                230                235                240
Thr Glu Ile Met Asp His Asn Val Ser Pro Phe Met Arg Lys Gly Thr 
                 245                250                255
Thr Gly Asp Trp Lys Asn Thr Phe Thr Val Ala Gln Asn Glu Arg Phe 
             260                265                270
Asp Ala His Tyr Ala Lys Thr Met Thr Asp Cys Asp Phe Lys Phe Arg 
         275                280                285
Cys Glu Leu 
     290



<210> 3004
<211> 1176
<212> DNA
<213> Homo sapiens
<308> L19999
<400> 3004

cacacagca  ccacaatca  ccactgcgg  cgaggaggg  acgaggcca  gttcccaag  60
gctcaggaa  atggagctg  tccaggaca  ctcccgccc  ccactggag  acgtgaagg  120
ggtcccgct  atcaagtac  ttgcagagg  actggggcc  ctgcagagc  tccaggccc  180
gcctgatga  ctgctcatc  gcacctacc  caagtccgg  actacctgg  taagccaga  240
tctggacat  atctaccag  gtggtgacc  ggagaagtg  caccgagct  ccatcttca  300
gcgggtgcc  ttccttgag  tcaaagccc  agggattcc  tcagggatg  agactctga  360
agacacacc  gccccacga  tcctgaaga  acacctgcc  ctggctctg  tcccccaga  420
tctgttgga  cagaaggtc  aggtggtct  tgttgcccg  aacgcaaag  atgtggcag  480
ttcctacta  cacttctac  acatggcca  ggtgcaccc  gagcctggg  cctgggaca  540
cttcctgga  aagttcatg  tcggagaag  gtcctacgg  tcctggtac  agcacgtgc  600
ggagtggtg  gagctgagc  gcacccacc  tgttctcta  ctcttctat  aagacatga  660
ggagaaccc  aaaagggag  ttcaaaaga  cctggagtt  gtggggcgc  ccctgccag  720
ggagaccgt  gacttcatg  ttcagcaca  gtcgttcaa  gagatgaag  agaacccta  780
gaccaacta  accaccgtc  cccaggagt  catggacca  agcatctcc  ccttcatga  840
gaaaggcat  gctggggac  ggaagacca  cttcaccgt  gcgcagaat  agcgcttcg  900
tgcggacta  gcgaagaag  tggcaggct  cagcctcac  ttccgctct  agctgtgag  960
ggggctcct  gagtcactg  agagggagt  tgcgaatca  acctgacca  gcggctcaa  1020
aataaaata  caattgagg  cccggacgg  aggtcatgt  tgtaatccc  gcaatttgg  1080
ggctgaggt  ggaggatca  ttgagccca  gagttcgag  ccaacctgg  caacatagt  1140
agattctgt  aaaaaaata  aataaaata  aaccaa  1176



<210> 3005
<211> 295
<212> PRT
<213> Homo sapiens
<308> P50225
<400> 3005

Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys 
  1               5                  10                  15
Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
             20                  25                  30
Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys 
         35                  40                  45
Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
     50                  55                  60
Gly Asp Leu Glu Lys Cys His Arg Ala Pro Ile Phe Met Arg Val Pro 
 65                  70                  75                  80
Phe Leu Glu Phe Lys Ala Pro Gly Ile Pro Ser Gly Met Glu Thr Leu 
                 85                  90                  95
Lys Asp Thr Pro Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ala 
             100                105                110
Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
         115                120                125
Ala Arg Asn Ala Lys Asp Val Ala Val Ser Tyr Tyr His Phe Tyr His 
     130                135                140
Met Ala Lys Val His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu 
 145                150                155                160
Lys Phe Met Val Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                 165                170                175
Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
             180                185                190
Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
         195                200                205
Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Val Asp Phe Met Val 
     210                215                220
Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
 225                230                235                240
Thr Thr Val Pro Gln Glu Phe Met Asp His Ser Ile Ser Pro Phe Met 
                 245                250                255
Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
             260                265                270
Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
         275                280                285
Leu Ser Phe Arg Ser Glu Leu 
     290                295



<210> 3006
<211> 1227
<212> DNA
<213> Rattus norvegicus
<308> L19998
<400> 3006

ggaattcgc  acgcctaca  aaagatccc  atcactgag  acccggagg  aaggctcag  60
accccagga  cagcaacat  gagttctcc  gtccaccgc  agtgcatgt  aagggtatc  120
cactcatca  atactttgc  gagacaatt  ggccattgc  gaacttcac  gcctggcct  180
atgacttgc  gatcagcac  tacccaaag  ctggtacta  ctggatgag  gagatcctg  240
atatgatct  tcagggtgg  aagctagag  agtgtggcc  cgcccccat  tatgcccgg  300
tacccttcc  tgagttcaa  tgtccaggg  ttccctcag  tcttgaaac  ttggaagag  360
caccagccc  acggctcct  aagacacat  tgcccctgt  cttgctccc  cagagtctg  420
tggatcaga  ggtcaaggt  atctacatt  cccgaaatg  aaaggatgt  gttgtctcc  480
attataact  ctacaacat  gccaagctg  accctgatc  aggcacctg  gacagcttc  540
tggagaact  catggatgg  gaagtgtcc  atgggtcgt  gtaccagca  gtgaaggag  600
ggtgggagc  gagacacac  caccctgtt  tctatctct  ctatgaaga  ataaaggag  660
accccaaaa  ggagatcaa  aagattcta  agtttttgg  gcgctctct  cccgaggag  720
ctgtggatt  cattgttca  cacacatct  tcaagaaaa  gaaagagaa  tgcatgact  780
actacacaa  catccccac  gagattatg  accacaatg  ttctccctt  atgaggaaa  840
gtactactg  ggactggaa  aataccttc  ctgtagccc  gaatgagcg  tttgatgcc  900
actatgcta  gacaatgac  gattgtgac  tcaagtttc  ttgtgaact  tgagtggat  960
atggctata  tgggaacca  ggcaaactg  cacagccca  catgatctc  agtaaaatg  1020
gatgtgttc  atctacttg  tgtatgcct  gaggaaatc  gagctaaga  aataggatt  1080
gggatgtgg  tgaggcaga  ggttttatc  acgcatgtc  ggaaagcaa  cagtcccaa  1140
acctaaaaa  aacctaaag  acaaacatg  aaaaaatag  aagataaac  atattttac  1200
tgaaagaat  aatgccact  ggaaatg  1227



<210> 3007
<211> 291
<212> PRT
<213> Rattus norvegicus
<308> P17988
<400> 3007

Met Glu Phe Ser Arg Pro Pro Leu Val His Val Lys Gly Ile Pro Leu 
  1               5                  10                  15
Ile Lys Tyr Phe Ala Glu Thr Ile Gly Pro Leu Gln Asn Phe Thr Ala 
             20                  25                  30
Trp Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys Ser Gly Thr Thr 
         35                  40                  45
Trp Met Ser Glu Ile Leu Asp Met Ile Tyr Gln Gly Gly Lys Leu Glu 
     50                  55                  60
Lys Cys Gly Arg Ala Pro Ile Tyr Ala Arg Val Pro Phe Leu Glu Phe 
 65                  70                  75                  80
Lys Cys Pro Gly Val Pro Ser Gly Leu Glu Thr Leu Glu Glu Thr Pro 
                 85                  90                  95
Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ser Leu Leu Pro Gln 
             100                105                110
Ser Leu Leu Asp Gln Lys Val Lys Val Ile Tyr Ile Ala Arg Asn Ala 
         115                120                125
Lys Asp Val Val Val Ser Tyr Tyr Asn Phe Tyr Asn Met Ala Lys Leu 
     130                135                140
His Pro Asp Pro Gly Thr Trp Asp Ser Phe Leu Glu Asn Phe Met Asp 
 145                150                155                160
Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val Lys Glu Trp Trp 
                 165                170                175
Glu Leu Arg His Thr His Pro Val Leu Tyr Leu Phe Tyr Glu Asp Ile 
             180                185                190
Lys Glu Asn Pro Lys Arg Glu Ile Lys Lys Ile Leu Glu Phe Leu Gly 
         195                200                205
Arg Ser Leu Pro Glu Glu Thr Val Asp Ser Ile Val His His Thr Ser 
     210                215                220
Phe Lys Lys Met Lys Glu Asn Cys Met Thr Asn Tyr Thr Thr Ile Pro 
 225                230                235                240
Thr Glu Ile Met Asp His Asn Val Ser Pro Phe Met Arg Lys Gly Thr 
                 245                250                255
Thr Gly Asp Trp Lys Asn Thr Phe Thr Val Ala Gln Asn Glu Arg Phe 
             260                265                270
Asp Ala His Tyr Ala Lys Thr Met Thr Asp Cys Asp Phe Lys Phe Arg 
         275                280                285
Cys Glu Leu 
     290



<210> 3008
<211> 1176
<212> DNA
<213> Homo sapiens
<308> L19999
<400> 3008

cacacagca  ccacaatca  ccactgcgg  cgaggaggg  acgaggcca  gttcccaag  60
gctcaggaa  atggagctg  tccaggaca  ctcccgccc  ccactggag  acgtgaagg  120
ggtcccgct  atcaagtac  ttgcagagg  actggggcc  ctgcagagc  tccaggccc  180
gcctgatga  ctgctcatc  gcacctacc  caagtccgg  actacctgg  taagccaga  240
tctggacat  atctaccag  gtggtgacc  ggagaagtg  caccgagct  ccatcttca  300
gcgggtgcc  ttccttgag  tcaaagccc  agggattcc  tcagggatg  agactctga  360
agacacacc  gccccacga  tcctgaaga  acacctgcc  ctggctctg  tcccccaga  420
tctgttgga  cagaaggtc  aggtggtct  tgttgcccg  aacgcaaag  atgtggcag  480
ttcctacta  cacttctac  acatggcca  ggtgcaccc  gagcctggg  cctgggaca  540
cttcctgga  aagttcatg  tcggagaag  gtcctacgg  tcctggtac  agcacgtgc  600
ggagtggtg  gagctgagc  gcacccacc  tgttctcta  ctcttctat  aagacatga  660
ggagaaccc  aaaagggag  ttcaaaaga  cctggagtt  gtggggcgc  ccctgccag  720
ggagaccgt  gacttcatg  ttcagcaca  gtcgttcaa  gagatgaag  agaacccta  780
gaccaacta  accaccgtc  cccaggagt  catggacca  agcatctcc  ccttcatga  840
gaaaggcat  gctggggac  ggaagacca  cttcaccgt  gcgcagaat  agcgcttcg  900
tgcggacta  gcgaagaag  tggcaggct  cagcctcac  ttccgctct  agctgtgag  960
ggggctcct  gagtcactg  agagggagt  tgcgaatca  acctgacca  gcggctcaa  1020
aataaaata  caattgagg  cccggacgg  aggtcatgt  tgtaatccc  gcaatttgg  1080
ggctgaggt  ggaggatca  ttgagccca  gagttcgag  ccaacctgg  caacatagt  1140
agattctgt  aaaaaaata  aataaaata  aaccaa  1176



<210> 3009
<211> 295
<212> PRT
<213> Homo sapiens
<308> P50225
<400> 3009

Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys 
  1               5                  10                  15
Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
             20                  25                  30
Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys 
         35                  40                  45
Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
     50                  55                  60
Gly Asp Leu Glu Lys Cys His Arg Ala Pro Ile Phe Met Arg Val Pro 
 65                  70                  75                  80
Phe Leu Glu Phe Lys Ala Pro Gly Ile Pro Ser Gly Met Glu Thr Leu 
                 85                  90                  95
Lys Asp Thr Pro Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ala 
             100                105                110
Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
         115                120                125
Ala Arg Asn Ala Lys Asp Val Ala Val Ser Tyr Tyr His Phe Tyr His 
     130                135                140
Met Ala Lys Val His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu 
 145                150                155                160
Lys Phe Met Val Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                 165                170                175
Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
             180                185                190
Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
         195                200                205
Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Val Asp Phe Met Val 
     210                215                220
Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
 225                230                235                240
Thr Thr Val Pro Gln Glu Phe Met Asp His Ser Ile Ser Pro Phe Met 
                 245                250                255
Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
             260                265                270
Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
         275                280                285
Leu Ser Phe Arg Ser Glu Leu 
     290                295



<210> 3010
<211> 1058
<212> DNA
<213> Rattus norvegicus
<308> L20427
<400> 3010

cattaaaat  tggcttaga  cttacagga  aacgttttc  tgtttgacc  gactaaaaa  60
ttacaggtc  tcttggaag  aattataca  tacttcaca  acagttgac  gcaaggagg  120
caaaacctt  caggccctg  ctcactcat  gtgggatga  caagggaag  ttgcgcctc  180
tcattctat  aatgaccta  gggtgccgt  cattagaga  aatcttttg  aaacaagta  240
taatcatga  ccaggaaag  ctttatctg  gatgaagat  ctcgacgtt  gctgtggcg  300
tgggttatt  actgaacct  tagggagac  gggagcttc  gttgttgga  tcgatcctg  360
ggctgaaaa  attaagata  cacagcacc  taaatcatt  gatccagtc  tggataaga  420
gatacagta  cgagtgtgc  ccctggagg  gaccttgaa  gagaatgca  agtgttttg  480
tgctgtcgt  gcttctgaa  tggtcgagc  tgtgaacaa  cttgaaatg  tcatacagt  540
ctgctatca  gtattgaaa  ctggtggct  tttattcat  actacagtg  acaaaacac  600
gctgtccta  gtcttggga  ttgttttct  agagcaaat  gcaggcatt  ttccaaaag  660
cactcatac  tgggagaag  ttgtttcac  tgaaaagct  gaaagcatc  tggaaccaa  720
tggtctgtc  gttgaaact  tggcaggaa  ggtctataa  cctttctca  gttactggc  780
ttggactga  aataccagc  ttaactatg  agcccatgc  gtgagagcc  gggctcagg  840
acacctgga  cctgctgag  ctgcttgaa  gggggaagc  gaagcaccc  atgccaaag  900
ctccggcag  ccaagtgtg  acgaggggc  gagaaaatg  gaaagctct  aggacagca  960
taaatatgc  tgaagttgt  ttgtttaca  atccaaaca  cttactcct  ttcgggagg  1020
attctgaag  acaaaaggt  aataaaaat  tctaaatc  1058



<210> 3011
<211> 286
<212> PRT
<213> Rattus norvegicus
<308> Q63159
<400> 3011

Met Trp Leu Arg Ser Tyr Arg Ile Thr Phe Ser Cys Leu Thr Arg Leu 
  1               5                  10                  15
Lys Thr Tyr Arg Ser Ser Trp Lys Lys Leu Tyr Ser Thr Ser Gln Thr 
             20                  25                  30
Val Asp Ser Lys Glu Val Lys Thr Phe Gln Ala Leu Ala His Ser Trp 
         35                  40                  45
Trp Asp Glu Gln Gly Lys Phe Ala Pro Leu His Ser Met Asn Asp Leu 
     50                  55                  60
Arg Val Pro Phe Ile Arg Asp Asn Leu Leu Lys Thr Ser Thr Asn His 
 65                  70                  75                  80
Asp Pro Gly Lys Pro Leu Ser Gly Met Lys Ile Leu Asp Val Gly Cys 
                 85                  90                  95
Gly Gly Gly Leu Leu Thr Glu Pro Leu Gly Arg Leu Gly Ala Ser Val 
             100                105                110
Val Gly Ile Asp Pro Val Ala Glu Asn Ile Lys Ile Ala Gln His His 
         115                120                125
Lys Ser Phe Asp Pro Val Leu Asp Lys Arg Ile Gln Tyr Arg Val Cys 
     130                135                140
Ser Leu Glu Glu Thr Leu Asn Glu Asn Ala Glu Cys Phe Asp Ala Val 
 145                150                155                160
Val Ala Ser Glu Val Val Glu His Val Asn Asn Leu Glu Met Phe Ile 
                 165                170                175
Gln Cys Cys Tyr Gln Val Leu Lys Pro Gly Gly Ser Leu Phe Ile Thr 
             180                185                190
Thr Val Asn Lys Thr Gln Leu Ser Tyr Val Leu Gly Ile Val Phe Ser 
         195                200                205
Glu Gln Ile Ala Gly Ile Val Pro Lys Gly Thr His Thr Trp Glu Lys 
     210                215                220
Phe Val Ser Pro Glu Lys Leu Glu Ser Ile Leu Glu Pro Asn Gly Leu 
 225                230                235                240
Ser Val Glu Thr Val Ala Gly Met Val Tyr Asn Pro Phe Ser Gly Tyr 
                 245                250                255
Trp His Trp Thr Glu Asn Thr Ser Leu Asn Tyr Ala Ala His Ala Val 
             260                265                270
Arg Ala Arg Ala Gln Glu His Leu Glu Pro Ala Glu Ser Ala 
         275                280                285



<210> 3012
<211> 1336
<212> DNA
<213> Homo sapiens
<308> AK056955
<400> 3012

aaaagaggt  ggatcgttt  tcgcgatgt  gagtggccg  aagctgggc  cctccgggg  60
ttggttttt  agagtgctg  ggcctggag  ctgtaatac  aaagctgcg  gtcccttaa  120
ttcctcggc  gtttatgtg  agaaccagc  cagtgggac  ctacagatt  aaccagggg  180
tttcaatga  tacagaacc  tatggttca  atcctacag  acgatcttt  cctgtttga  240
cagaataaa  agtttcagg  acccttggg  gagactgta  agtacttcc  aaaccactg  300
cgacagcgg  gaggtaaaa  ccttcttgg  cctggctca  aaatggtgg  atgaacaag  360
agtatatgc  cctcttcat  ccatgaatg  cctgagggt  ccatttatt  gggacaatc  420
tctgaaaac  attcctaat  accagccag  aaaaccttt  ttggggatg  agattcttg  480
cgttggctg  ggtggtggg  tgttaactg  acctctagg  cggcttggg  cttcagtta  540
tggaatcga  cctgtggat  agaacatta  aacagcaca  tgccataaa  catttgatc  600
agtcctgga  aagagaata  agtacagag  gtgttccct  gaagagatt  tggaagaga  660
tgcagaaac  tttgatgct  ttgtagctt  tgaagttgt  gaacatgtg  ttgatctag  720
aacattttt  cagtgctgc  gtcaagtgt  aaaacccgg  ggttcttta  tcattacta  780
aatcaacaa  acacaactt  cctatgcct  gggaattgt  ttttcagag  aaattgcag  840
tattgtacc  aaaggtact  atacatggg  gaagtttgt  tcacctgaa  cactagaga  900
cattctgga  tcaaatggt  tgtcagttc  aacagtggt  ggaatgctc  ataacccct  960
ctcaggtta  tggcattgg  gtgaaaata  cagccttaa  tatgcagct  atgctgtga  1020
atccagggt  caggaacac  cagcctctg  tgagtttgt  ttaaaggga  agacagaag  1080
gctccaagc  aatgcctgc  ccaatccag  tgtgcatga  aagctgaag  aatgaattg  1140
ttctgagaa  tatagtaat  tggcttgga  atctgatgt  ttcaaatac  agaaatgta  1200
aatttatcc  ttgagagag  atcatgaag  aaagaaggt  aataaaaag  gctaaaacc  1260
tggacaaaa  tttttgtta  ttcgtctaa  agctacttt  aagggattc  gtgaataaa  1320
agttttgtc  agatat  1336



<210> 3013
<211> 310
<212> PRT
<213> Homo sapiens
<308> Q9NZJ6
<400> 3013

Met Phe Lys Ser Tyr Arg Thr Ile Phe Ser Cys Leu Asn Arg Ile Lys 
  1               5                  10                  15
Ser Phe Arg Tyr Pro Trp Ala Arg Leu Tyr Ser Thr Ser Gln Thr Thr 
             20                  25                  30
Val Asp Ser Gly Glu Val Lys Thr Phe Leu Ala Leu Ala His Lys Trp 
         35                  40                  45
Trp Asp Glu Gln Gly Val Tyr Ala Pro Leu His Ser Met Asn Asp Leu 
     50                  55                  60
Arg Val Pro Phe Ile Arg Asp Asn Leu Leu Lys Thr Ile Pro Asn His 
 65                  70                  75                  80
Gln Pro Gly Lys Pro Leu Leu Gly Met Lys Ile Leu Asp Val Gly Cys 
                 85                  90                  95
Gly Gly Gly Leu Leu Thr Glu Pro Leu Gly Arg Leu Gly Ala Ser Val 
             100                105                110
Ile Gly Ile Asp Pro Val Asp Glu Asn Ile Lys Thr Ala Gln Cys His 
         115                120                125
Lys Ser Phe Asp Pro Val Leu Asp Lys Arg Ile Glu Tyr Arg Val Cys 
     130                135                140
Ser Leu Glu Glu Ile Val Glu Glu Thr Ala Glu Thr Phe Asp Ala Val 
 145                150                155                160
Val Ala Ser Glu Val Val Glu His Val Ile Asp Leu Glu Thr Phe Leu 
                 165                170                175
Gln Cys Cys Cys Gln Val Leu Lys Pro Gly Gly Ser Leu Phe Ile Thr 
             180                185                190
Thr Ile Asn Lys Thr Gln Leu Ser Tyr Ala Leu Gly Ile Val Phe Ser 
         195                200                205
Glu Gln Ile Ala Gly Ile Val Pro Lys Gly Thr His Thr Trp Glu Lys 
     210                215                220
Phe Val Ser Pro Glu Thr Leu Glu Ser Ile Leu Glu Ser Asn Gly Leu 
 225                230                235                240
Ser Val Gln Thr Val Val Gly Met Leu Tyr Asn Pro Phe Ser Gly Tyr 
                 245                250                255
Trp His Trp Ser Glu Asn Thr Ser Leu Asn Tyr Ala Ala His Ala Val 
             260                265                270
Lys Ser Arg Val Gln Glu His Pro Ala Ser Ala Glu Phe Val Leu Lys 
         275                280                285
Gly Glu Thr Glu Glu Leu Gln Ala Asn Ala Cys Thr Asn Pro Ala Cys 
     290                295                300
Ile Glu Lys Leu Lys Lys 
 305                310



<210> 3014
<211> 1608
<212> DNA
<213> Rattus norvegicus
<308> L20822
<400> 3014

acggatcag  gtgtctacc  gggtctctc  aagacacag  ttctgtccc  tgcaactgc  60
atcaatagc  gcagtgaca  cgctccttt  cccaccccg  tggccctgg  cccctcccc  120
cccgacact  tgtcctgcc  ggatcggac  caggagttc  tgtctgcct  caagtcgct  180
cagagccgt  agaatggaa  ccaaacaaa  aaaccagct  tgcacgcta  ccggcagtg  240
agcgagttt  ccctcatgg  caggcgcat  gggaaagat  tcagcaata  atttgccaa  300
ctggagaag  taacaatcc  ggcaaagcg  aagtccctc  ttgatgata  agcagtaga  360
attgaggaa  taacataca  catcaaaca  gacatcaat  gcctcaaca  acaaattgc  420
cagcttcaa  attttgtga  ggccaaggg  agccagagt  gccggcatc  gcagaccca  480
tccaacacc  ttgtagttt  attgcagtc  aaactggct  ccatgtcca  tgacttcaa  540
tctgttttg  aagtgagga  tgaaaatct  aaacagcag  ggaaccgtc  ggaacagtt  600
tccagggcg  cagtgtcgg  actgcctct  gcccccaac  accttggag  tggtcccat  660
gttctggga  gagagtccc  agcctccag  gacgtggcc  tcgacatga  ggaccctag  720
acaagccag  agcttcagc  cattgatga  caggattcc  acatccaga  tcgggcaga  780
accatgcag  acattgagt  tacaattgt  gagctgggc  ccatttttc  acaattggc  840
cacatggtt  aagaacagg  ggaaacaat  cagaggatt  acgagaatg  gcttggagc  900
cagctggat  ttgaggccg  ccattcaga  atcctcaag  acttccagt  agtcacctc  960
aatcggtgg  tcatggtca  aatcttcct  atcctcatt  tcttcttca  catctttgt  1020
gtcttcctt  cctgaaccc  cctccctca  tctgagcca  tccatggag  gcctggaac  1080
cttctggaa  gacaggtgg  cactattgc  actgagcct  tgcagggta  ttgggagaa  1140
ggccatttc  ttggaactg  taagaatgg  cagtgtccc  gattcccca  ccttgtctc  1200
ggccactct  tcctaccct  aggcccatg  aacacactg  ttctggatt  ggcctctgc  1260
gtgaagtgg  agggaacag  agccagcta  ggccagtgg  gaggttgtc  ctaccatga  1320
atttttata  acccagacc  gcctcccct  aaggtaact  gcagcaaga  gaaacaatg  1380
cctccttgc  ttctggaga  tgaggtgag  aagtaaaac  atcccaggg  ccaacttaa  1440
catctgggt  atctagaac  tgactgcca  cttctcctc  ccatgtgag  tgggggggc  1500
ctgagccct  cagttgcac  aacctgact  tggctactg  tgactctca  tctgccaaa  1560
atgctgcag  ctgtttcct  ccaattaca  caagactgt  agccttca  1608



<210> 3015
<211> 301
<212> PRT
<213> Rattus norvegicus
<308> Q08851
<400> 3015

Met Ser Cys Arg Asp Arg Thr Gln Glu Phe Leu Ser Ala Cys Lys Ser 
  1               5                  10                  15
Leu Gln Ser Arg Gln Asn Gly Ile Gln Thr Asn Lys Pro Ala Leu His 
             20                  25                  30
Ala Thr Arg Gln Cys Ser Glu Phe Thr Leu Met Ala Arg Arg Ile Gly 
         35                  40                  45
Lys Asp Leu Ser Asn Thr Phe Ala Lys Leu Glu Lys Leu Thr Ile Leu 
     50                  55                  60
Ala Lys Arg Lys Ser Leu Phe Asp Asp Lys Ala Val Glu Ile Glu Glu 
 65                  70                  75                  80
Leu Thr Tyr Ile Ile Lys Gln Asp Ile Asn Ser Leu Asn Lys Gln Ile 
                 85                  90                  95
Ala Gln Leu Gln Asp Phe Val Arg Ala Lys Gly Ser Gln Ser Gly Arg 
             100                105                110
His Leu Gln Thr His Ser Asn Thr Ile Val Val Ser Leu Gln Ser Lys 
         115                120                125
Leu Ala Ser Met Ser Asn Asp Phe Lys Ser Val Leu Glu Val Arg Thr 
     130                135                140
Glu Asn Leu Lys Gln Gln Arg Asn Arg Arg Glu Gln Phe Ser Arg Ala 
 145                150                155                160
Pro Val Ser Ala Leu Pro Leu Ala Pro Asn Asn Leu Gly Gly Gly Pro 
                 165                170                175
Ile Val Leu Gly Gly Glu Ser Arg Ala Ser Arg Asp Val Ala Ile Asp 
             180                185                190
Met Met Asp Pro Arg Thr Ser Gln Gln Leu Gln Leu Ile Asp Glu Gln 
         195                200                205
Asp Ser Tyr Ile Gln Ser Arg Ala Asp Thr Met Gln Asn Ile Glu Ser 
     210                215                220
Thr Ile Val Glu Leu Gly Ser Ile Phe Gln Gln Leu Ala His Met Val 
 225                230                235                240
Lys Glu Gln Glu Glu Thr Ile Gln Arg Ile Asp Glu Asn Val Leu Gly 
                 245                250                255
Ala Gln Leu Asp Val Glu Ala Ala His Ser Glu Ile Leu Lys Tyr Phe 
             260                265                270
Gln Ser Val Thr Ser Asn Arg Trp Leu Met Val Lys Ile Phe Leu Ile 
         275                280                285
Leu Ile Val Phe Phe Ile Ile Phe Val Val Phe Leu Ala 
     290                295                300



<210> 3016
<211> 1507
<212> DNA
<213> Homo sapiens
<308> NM_003164
<400> 3016

ctcgaggcc  cgaaggccc  gacaccatg  cctgccggg  tcggaccca  gagtttctg  60
ctgcctgca  gtcgctgca  acccgtcag  atggaatcc  gacaaataa  ccagctttg  120
gtgctgtcc  acaacgcag  gaattcacc  tcatggcca  gcgcattgg  aaagacctt  180
gcaacacat  tgccaagct  gagaagctg  caatcttgg  aaagcgcaa  tccctcttt  240
atgataaag  agtggaaat  gaagagcta  catatatca  caaacagga  atcaatagc  300
tcaacaaac  aattgctca  ctccaggat  tcgtgagag  caagggcag  cagagtggc  360
ggcacctgc  gacccactc  aacaccatt  tggtctcct  gcagtcgaa  ctggcttct  420
tgtccaatg  cttcaaatc  gttttagaa  tgaggacag  gaacctgaa  cagcagagg  480
gccggagag  gcagttctc  cgggcacct  tgtcagccc  gccccttgc  cctaaccac  540
tgggcggtg  tgctgtggt  ctgggggca  agtcccatg  ctccaagga  gtcgccatc  600
acatgatgg  ctctcggac  agccagcag  tgcagctca  tgacgagca  gattcctac  660
tccagagtc  ggcagacac  atgcagaac  ttgagtcga  aattgttga  ttgggctcc  720
tctttcagc  gttggcaca  atggttaag  aacaggagg  aaccattca  aggatcgac  780
agaacgtgc  aggagccca  ctggacgtt  aggccgccc  ttcagagat  ctcaagtac  840
tccagtctg  cacctccaa  cggtggctc  tggtcaaaa  cttcctcat  ctcattgtc  900
tcttcatca  ctttgtggt  ttccttgct  gaaccctct  tactctgag  cactctgtt  960
gggtttggg  ccctcctgg  aaggcaagt  gccagtgct  ccactgagc  tgtgcaggg  1020
acttgggag  aaggccctg  ttccctgga  ctgctaaga  tgaccactg  ccctgatcc  1080
ccacccctt  cctctggcc  ccctgtcct  cccccacca  cctcaggcc  atgaaacac  1140
cagggttct  gatttgaac  ctgctgtga  gtgactgga  gggagcaga  gccagctgg  1200
ggccagtgg  ggaggttgt  tccactagg  gatttttat  aaccctctc  agcctctcc  1260
ggaaaggaa  cgttggcag  aaagggaga  gatgccctt  cccaccttc  tgtgagtga  1320
gagaggaag  agccccagg  accaatttt  ccaattgac  tctttcttc  tctttcacc  1380
tgtgaggca  ggagccctg  gcccttcag  tgcctgcac  acccctgac  ttggctgct  1440
gtgactcaa  ctgccaaat  tgctgcagc  cgttttctc  caattacag  aagactgtc  1500
gcctcca  1507



<210> 3017
<211> 301
<212> PRT
<213> Homo sapiens
<308> Q13190
<400> 3017

Met Ser Cys Arg Asp Arg Thr Gln Glu Phe Leu Ser Ala Cys Lys Ser 
  1               5                  10                  15
Leu Gln Thr Arg Gln Asn Gly Ile Gln Thr Asn Lys Pro Ala Leu Arg 
             20                  25                  30
Ala Val Arg Gln Arg Ser Glu Phe Thr Leu Met Ala Lys Arg Ile Gly 
         35                  40                  45
Lys Asp Leu Ser Asn Thr Phe Ala Lys Leu Glu Lys Leu Thr Ile Leu 
     50                  55                  60
Ala Lys Arg Lys Ser Leu Phe Asp Asp Lys Ala Val Glu Ile Glu Glu 
 65                  70                  75                  80
Leu Thr Tyr Ile Ile Lys Gln Asp Ile Asn Ser Leu Asn Lys Gln Ile 
                 85                  90                  95
Ala Gln Leu Gln Asp Phe Val Arg Ala Lys Gly Ser Gln Ser Gly Arg 
             100                105                110
His Leu Gln Thr His Ser Asn Thr Ile Val Val Ser Leu Gln Ser Lys 
         115                120                125
Leu Ala Ser Met Ser Asn Asp Phe Lys Ser Val Leu Glu Val Arg Thr 
     130                135                140
Glu Asn Leu Lys Gln Gln Arg Ser Arg Arg Glu Gln Phe Ser Arg Ala 
 145                150                155                160
Pro Val Ser Ala Leu Pro Leu Ala Pro Asn His Leu Gly Gly Gly Ala 
                 165                170                175
Val Val Leu Gly Ala Glu Ser His Ala Ser Lys Asp Val Ala Ile Asp 
             180                185                190
Met Met Asp Ser Arg Thr Ser Gln Gln Leu Gln Leu Ile Asp Glu Gln 
         195                200                205
Asp Ser Tyr Ile Gln Ser Arg Ala Asp Thr Met Gln Asn Ile Glu Ser 
     210                215                220
Thr Ile Val Glu Leu Gly Ser Ile Phe Gln Gln Leu Ala His Met Val 
 225                230                235                240
Lys Glu Gln Glu Glu Thr Ile Gln Arg Ile Asp Glu Asn Val Leu Gly 
                 245                250                255
Ala Gln Leu Asp Val Glu Ala Ala His Ser Glu Ile Leu Lys Tyr Phe 
             260                265                270
Gln Ser Val Thr Ser Asn Arg Trp Leu Met Val Lys Ile Phe Leu Ile 
         275                280                285
Leu Ile Val Phe Phe Ile Ile Phe Val Val Phe Leu Ala 
     290                295                300



<210> 3018
<211> 2094
<212> DNA
<213> Rattus norvegicus
<308> L20900
<400> 3018

ggcacgagc  ccgatctcc  ctgagaggc  cctgggggc  ggggctccg  ggaaaatgg  60
tcgatgtta  taaaaatga  tcttaagaa  aaaaatgaa  cacagcagt  aaactatgg  120
gttctgcta  ttgtaagaa  tggagaagc  tgagattac  tcactgacc  ttgatcctc  180
actgagcta  aacaccagc  ggtaattgc  tatgatttt  tagacttcc  tccatctgc  240
gggtccaag  gtccgtctg  ctgctctgg  accggagca  ctttatttc  gcatctaaa  300
ttgtaaaaa  cacatcgaa  cttgttccc  aggagaaaa  cttcaatgt  accattttc  360
atgtatccg  tgatacaag  gcattgtaa  ctccaggta  aagcagctt  atcagtgga  420
agggtttaa  agaacatat  ctatcatgc  ttttctctg  cccttctca  atcatcagc  480
gtagaaaag  gaagaaaac  tgtcaggac  caaatgtta  tcctgggag  tgcaggatc  540
gtttgctca  gataagtca  ttgtcaata  gatgcaaca  aaatattgg  aaacgaatg  600
ggcctttat  aaagccaca  ggaagaagg  agatgaaca  gtcgttgct  ctgatgcag  660
cctggatgc  aagctagag  tgtttcatt  gattcagag  acctgtttg  acttgtcta  720
agcaattgt  ctctatcaa  agagaatat  tttcttgtc  caagaagaa  atgaactgg  780
aaaatttct  cgatcccaa  gcttccagg  caaaacccg  gcaggaaaa  tgatgcaag  840
cacaggaaa  gccctctgc  tttcctccc  gcaaaggtt  gccttgaga  accctttgt  900
tcgatttca  caagaagta  agactttta  acatcgggc  atctccgat  cctggctga  960
agtgaaccg  atggagcag  gccggacag  atatagagg  gcgttattg  ggatgaagg  1020
cgtgtctca  gaactggat  cagacctct  caagcaaat  gagaagttc  ggaaggtac  1080
gacacaagt  cgcctcgcg  agaagaact  tgacaaatt  aagatggat  tgtgtcaaa  1140
ggtggatct  cttggagca  gcagatgta  cctcttatc  cacatgcta  caacatatc  1200
gaccactct  ctccacttt  gggagaaaa  ttctcacac  atggcagcc  tccatgaga  1260
cttcaaagg  tatcaacca  atgaattca  aacgttaaa  agcttacaa  accctatga  1320
aaagctagt  gagaaagaa  agaagaaga  ctcccggag  gaaaaccgg  aggctgtgg  1380
acaggagcc  aggcagtta  tttcattgg  ggaagagaa  cagcacaaa  aatcctcta  1440
ttgccagaa  gaggaggga  aaagcgttc  gtcgtctgt  gacaagagt  ctgcagatg  1500
tgcatgctc  ggacccata  atgaactat  agacgtgaa  cctgaggaa  cttgcctgg  1560
tcccatggc  gggacccca  aacctgaaa  tggggacaa  gacgacctc  tgctgttga  1620
cgagatctt  agcacttcc  gcctggatg  aggggagtt  agcagggag  gggctgcgg  1680
gttcggaga  gaccggctg  aggaaccag  ccccatggg  gcccaggga  agccagacc  1740
caagcccca  ataggctct  cgttccttc  ttcacagct  ttagaccaa  acatgaaag  1800
tctccaggc  tctctccaa  agcctgcca  ggctgcctc  gacctgact  cctggttca  1860
cctctttgc  gacctcgac  ccctatcaa  tcctgatgc  attgggaaa  ccgataaag  1920
acacgaatt  ctcaatgca  gagtctgca  ccttcaaca  gggagccct  cggccactc  1980
gcaacacct  atccagggc  tgcagaagt  taacgtgct  agtacgctg  tttaatatt  2040
acatgccat  ttaataaaa  gagagggtc  aggccctgt  tctatcgct  taaa  2094



<210> 3019
<211> 481
<212> PRT
<213> Rattus norvegicus
<308> L20900
<400> 3019

Met Ser Gly His Lys Cys Tyr Ser Trp Glu Leu Gln Asp Arg Phe Ala 
  1               5                  10                  15
Gln Asp Lys Ser Val Val Asn Lys Met Gln Gln Lys Tyr Trp Glu Thr 
             20                  25                  30
Asn Glu Ala Phe Ile Lys Ala Thr Gly Lys Lys Glu Asp Glu His Val 
         35                  40                  45
Val Ala Ser Asp Ala Asp Leu Asp Ala Lys Leu Glu Leu Phe His Ser 
     50                  55                  60
Ile Gln Arg Thr Cys Leu Asp Leu Ser Lys Ala Ile Val Leu Tyr Gln 
 65                  70                  75                  80
Lys Arg Ile Cys Phe Leu Ser Gln Glu Glu Asn Glu Leu Gly Lys Phe 
                 85                  90                  95
Leu Arg Ser Gln Gly Phe Gln Asp Lys Thr Arg Ala Gly Lys Met Met 
             100                105                110
Gln Ala Thr Gly Lys Ala Leu Cys Phe Ser Ser Gln Gln Arg Leu Ala 
         115                120                125
Leu Arg Asn Pro Leu Cys Arg Phe His Gln Glu Val Glu Thr Phe Arg 
     130                135                140
His Arg Ala Ile Ser Asp Thr Trp Leu Thr Val Asn Arg Met Glu Gln 
 145                150                155                160
Cys Arg Thr Glu Tyr Arg Gly Ala Leu Leu Trp Met Lys Asp Val Ser 
                 165                170                175
Gln Glu Leu Asp Pro Asp Leu Tyr Lys Gln Met Glu Lys Phe Arg Lys 
             180                185                190
Val Gln Thr Gln Val Arg Leu Ala Lys Lys Asn Phe Asp Lys Leu Lys 
         195                200                205
Met Asp Val Cys Gln Lys Val Asp Leu Leu Gly Ala Ser Arg Cys Asn 
     210                215                220
Leu Leu Ser His Met Leu Ala Thr Tyr Gln Thr Thr Leu Leu His Phe 
 225                230                235                240
Trp Glu Lys Thr Ser His Thr Met Ala Ala Ile His Glu Ser Phe Lys 
                 245                250                255
Gly Tyr Gln Pro Tyr Glu Phe Thr Thr Leu Lys Ser Leu Gln Asp Pro 
             260                265                270
Met Lys Lys Leu Val Glu Lys Glu Lys Lys Lys Ser Ser Arg Arg Glu 
         275                280                285
Asn Arg Glu Ala Val Ala Gln Glu Pro Arg Gln Leu Ile Ser Leu Glu 
     290                295                300
Glu Glu Asn Gln His Lys Glu Ser Ser Thr Cys Gln Lys Glu Glu Gly 
 305                310                315                320
Lys Ser Val Pro Ser Ser Val Asp Lys Ser Ser Ala Asp Asp Ala Cys 
                 325                330                335
Ser Gly Pro Ile Asp Glu Leu Leu Asp Val Lys Pro Glu Glu Ala Cys 
             340                345                350
Leu Gly Pro Met Ala Gly Thr Pro Glu Pro Glu Ser Gly Asp Lys Asp 
         355                360                365
Asp Leu Leu Leu Leu Asn Glu Ile Phe Ser Thr Ser Ser Leu Asp Glu 
     370                375                380
Gly Glu Phe Ser Arg Glu Trp Ala Ala Val Phe Gly Asp Asp Arg Leu 
 385                390                395                400
Lys Glu Pro Ala Pro Met Gly Ala Gln Gly Glu Pro Asp Pro Lys Pro 
                 405                410                415
Gln Ile Gly Ser Ala Phe Leu Pro Ser Gln Leu Leu Asp Gln Asn Met 
             420                425                430
Lys Asp Leu Gln Ala Ser Leu Gln Glu Pro Ala Lys Ala Ala Ser Asp 
         435                440                445
Leu Thr Ala Trp Phe Ser Leu Phe Ala Asp Leu Asp Pro Leu Ser Asn 
     450                455                460
Pro Asp Ala Ile Gly Lys Thr Asp Lys Glu His Glu Leu Leu Asn Ala 
 465                470                475                480
Ter 
                 485



<210> 3021
<211> 483
<212> PRT
<213> Homo sapiens
<308> Q05084
<400> 3021

Met Ser Gly His Lys Cys Ser Tyr Pro Trp Asp Leu Gln Asp Arg Tyr 
  1               5                  10                  15
Ala Gln Asp Lys Ser Val Val Asn Lys Met Gln Gln Lys Tyr Trp Glu 
             20                  25                  30
Thr Lys Gln Ala Phe Ile Lys Ala Thr Gly Lys Lys Glu Asp Glu His 
         35                  40                  45
Val Val Ala Ser Asp Ala Asp Leu Asp Ala Lys Leu Glu Leu Phe His 
     50                  55                  60
Ser Ile Gln Arg Thr Cys Leu Asp Leu Ser Lys Ala Ile Val Leu Tyr 
 65                  70                  75                  80
Gln Lys Arg Ile Cys Phe Leu Ser Gln Glu Glu Asn Glu Leu Gly Lys 
                 85                  90                  95
Phe Leu Arg Ser Gln Gly Phe Gln Asp Lys Thr Arg Ala Gly Lys Met 
             100                105                110
Met Gln Ala Thr Gly Lys Ala Leu Cys Phe Ser Ser Gln Gln Arg Leu 
         115                120                125
Ala Leu Arg Asn Pro Leu Cys Arg Phe His Gln Glu Val Glu Thr Phe 
     130                135                140
Arg His Arg Ala Ile Ser Asp Thr Trp Leu Thr Val Asn Arg Met Glu 
 145                150                155                160
Gln Cys Arg Thr Glu Tyr Arg Gly Ala Leu Leu Trp Met Lys Asp Val 
                 165                170                175
Ser Gln Glu Leu Asp Pro Asp Leu Tyr Lys Gln Met Glu Lys Phe Arg 
             180                185                190
Lys Val Gln Thr Gln Val Arg Leu Ala Lys Lys Asn Phe Asp Lys Leu 
         195                200                205
Lys Met Asp Val Cys Gln Lys Val Asp Leu Leu Gly Ala Ser Arg Cys 
     210                215                220
Asn Leu Leu Ser His Met Leu Ala Thr Tyr Gln Thr Thr Leu Leu His 
 225                230                235                240
Phe Trp Glu Lys Thr Ser His Thr Met Ala Ala Ile His Glu Ser Phe 
                 245                250                255
Lys Gly Tyr Gln Pro Tyr Glu Phe Thr Thr Leu Lys Ser Leu Gln Asp 
             260                265                270
Pro Met Lys Lys Leu Val Glu Lys Glu Glu Lys Lys Lys Ile Asn Gln 
         275                280                285
Gln Glu Ser Thr Asp Ala Ala Val Gln Glu Pro Ser Gln Leu Ile Ser 
     290                295                300
Leu Glu Glu Glu Asn Gln Arg Lys Glu Ser Ser Ser Phe Lys Thr Glu 
 305                310                315                320
Asp Gly Lys Ser Ile Leu Ser Ala Leu Asp Lys Gly Ser Thr His Thr 
                 325                330                335
Ala Cys Ser Gly Pro Ile Asp Glu Leu Leu Asp Met Lys Ser Glu Glu 
             340                345                350
Gly Ala Cys Leu Gly Pro Val Ala Gly Thr Pro Glu Pro Glu Gly Ala 
         355                360                365
Asp Lys Asp Asp Leu Leu Leu Leu Ser Glu Ile Phe Asn Ala Ser Ser 
     370                375                380
Leu Glu Glu Gly Glu Phe Ser Lys Glu Trp Ala Ala Val Phe Gly Asp 
 385                390                395                400
Gly Gln Val Lys Glu Pro Val Pro Thr Met Ala Leu Gly Glu Pro Asp 
                 405                410                415
Pro Lys Ala Gln Thr Gly Ser Gly Phe Leu Pro Ser Gln Leu Leu Asp 
             420                425                430
Gln Asn Met Lys Asp Leu Gln Ala Ser Leu Gln Glu Pro Ala Lys Ala 
         435                440                445
Ala Ser Asp Leu Thr Ala Trp Phe Ser Leu Phe Ala Asp Leu Asp Pro 
     450                455                460
Leu Ser Asn Pro Asp Ala Val Gly Lys Thr Asp Lys Glu His Glu Leu 
 465                470                475                480
Leu Asn Ala 
                 485



<210> 3022
<211> 863
<212> DNA
<213> Rattus norvegicus
<308> L21711
<400> 3022

agcaagtga  gaagagagc  ttggttctc  caagacaga  gagatgtct  ccttcagca  60
ccagactcc  tacccgaac  tagctgtac  tttcttcac  agcatccca  atgggcttt  120
cccatccaa  tccatcgtc  tatcaggcg  ggtcttgtc  gatgctaag  ggttccaga  180
caaccttcg  tgtgggggt  acattgctt  ccacctgaa  ccccgtttt  atgagaatg  240
tgtggtccg  aacactcag  tcaacaact  ctgggggcc  gaagagcga  gcctgcctg  300
gagtatgcc  ttcagtcgt  gccagagat  ctcagtgtg  atcttatgt  aaggtcact  360
cttcaaggt  gccgtggac  gtcagcata  ttgtgaata  agccaccgc  tgatgaact  420
gccggatat  cagctaaca  acgtggaga  ctaggaagg  ctctggcct  gggatgaag  480
ctgaggaac  ctacctgag  cttgtcacc  cttccctgt  tcagccctg  ctccccaaa  540
cctgtcatc  aagagagcc  cattggcag  agttccagg  aggtgacat  cccaattca  600
accctccac  aagggggag  cctgggctg  gggacacat  gctgtgagc  cacagtgtc  660
gccattgct  ccaagctag  catcttctg  gggaagtga  ctccctggg  ttgcccctt  720
ctctgaccc  ttcccttca  cctccagga  ggccacctt  atgtcatcc  actggcctc  780
aactgaccc  gaatgtcca  attaacttt  ccccaatct  tcccaatgc  cataaaata  840
agaatatca  cgcttgtct  cac  863



<210> 3023
<211> 144
<212> PRT
<213> Rattus norvegicus
<308> AAA65445
<400> 3023

Ser Ser Phe Ser Thr Gln Thr Pro Tyr Pro Asn Leu Ala Val Pro Phe 
  1               5                  10                  15
Phe Thr Ser Ile Pro Asn Gly Leu Tyr Pro Ser Lys Ser Ile Val Ile 
             20                  25                  30
Ser Gly Val Val Leu Ser Asp Ala Lys Arg Phe Gln Ile Asn Leu Arg 
         35                  40                  45
Cys Gly Gly Asp Ile Ala Phe His Leu Asn Pro Arg Phe Asp Glu Asn 
     50                  55                  60
Ala Val Val Arg Asn Thr Gln Ile Asn Asn Ser Trp Gly Pro Glu Glu 
 65                  70                  75                  80
Arg Ser Leu Pro Gly Ser Met Pro Phe Ser Arg Gly Gln Arg Phe Ser 
                 85                  90                  95
Val Trp Ile Leu Cys Glu Gly His Cys Phe Lys Val Ala Val Asp Gly 
             100                105                110
Gln His Ile Cys Glu Tyr Ser His Arg Leu Met Asn Leu Pro Asp Ile 
         115                120                125
Asn Thr Leu Glu Val Ala Gly Asp Ile Gln Leu Thr His Val Glu Thr 
     130                135                140



<210> 3024
<211> 863
<212> DNA
<213> Rattus norvegicus
<308> L21711
<400> 3024

agcaagtga  gaagagagc  ttggttctc  caagacaga  gagatgtct  ccttcagca  60
ccagactcc  tacccgaac  tagctgtac  tttcttcac  agcatccca  atgggcttt  120
cccatccaa  tccatcgtc  tatcaggcg  ggtcttgtc  gatgctaag  ggttccaga  180
caaccttcg  tgtgggggt  acattgctt  ccacctgaa  ccccgtttt  atgagaatg  240
tgtggtccg  aacactcag  tcaacaact  ctgggggcc  gaagagcga  gcctgcctg  300
gagtatgcc  ttcagtcgt  gccagagat  ctcagtgtg  atcttatgt  aaggtcact  360
cttcaaggt  gccgtggac  gtcagcata  ttgtgaata  agccaccgc  tgatgaact  420
gccggatat  cagctaaca  acgtggaga  ctaggaagg  ctctggcct  gggatgaag  480
ctgaggaac  ctacctgag  cttgtcacc  cttccctgt  tcagccctg  ctccccaaa  540
cctgtcatc  aagagagcc  cattggcag  agttccagg  aggtgacat  cccaattca  600
accctccac  aagggggag  cctgggctg  gggacacat  gctgtgagc  cacagtgtc  660
gccattgct  ccaagctag  catcttctg  gggaagtga  ctccctggg  ttgcccctt  720
ctctgaccc  ttcccttca  cctccagga  ggccacctt  atgtcatcc  actggcctc  780
aactgaccc  gaatgtcca  attaacttt  ccccaatct  tcccaatgc  cataaaata  840
agaatatca  cgcttgtct  cac  863



<210> 3025
<211> 144
<212> PRT
<213> Rattus norvegicus
<308> AAA65445
<400> 3025

Ser Ser Phe Ser Thr Gln Thr Pro Tyr Pro Asn Leu Ala Val Pro Phe 
  1               5                  10                  15
Phe Thr Ser Ile Pro Asn Gly Leu Tyr Pro Ser Lys Ser Ile Val Ile 
             20                  25                  30
Ser Gly Val Val Leu Ser Asp Ala Lys Arg Phe Gln Ile Asn Leu Arg 
         35                  40                  45
Cys Gly Gly Asp Ile Ala Phe His Leu Asn Pro Arg Phe Asp Glu Asn 
     50                  55                  60
Ala Val Val Arg Asn Thr Gln Ile Asn Asn Ser Trp Gly Pro Glu Glu 
 65                  70                  75                  80
Arg Ser Leu Pro Gly Ser Met Pro Phe Ser Arg Gly Gln Arg Phe Ser 
                 85                  90                  95
Val Trp Ile Leu Cys Glu Gly His Cys Phe Lys Val Ala Val Asp Gly 
             100                105                110
Gln His Ile Cys Glu Tyr Ser His Arg Leu Met Asn Leu Pro Asp Ile 
         115                120                125
Asn Thr Leu Glu Val Ala Gly Asp Ile Gln Leu Thr His Val Glu Thr 
     130                135                140



<210> 3026
<211> 498
<212> DNA
<213> Rattus norvegicus
<308> L22788
<400> 3026

cgcgtccgt  ctcagttgc  tctctgctg  cagctctct  ccagcacta  ggccttcac  60
ggcaaatac  aatttgaaa  tgagaagaa  tacgacgag  tcatgaagc  cctgggtct  120
ccagaagat  tgattgaaa  gggacgtaa  ttcaagatc  tcacagagg  ccagcagga  180
ggagagaac  tcacctggt  ccagtctta  tctgggggc  acatcatga  caacaagtt  240
accattggc  aagaatgtg  aatgcagac  atggggggc  agaagttca  ggcaaccgt  300
aagatggag  gtggcaagg  ggtggcaga  ttccccaac  atcaccaga  ttcggaggt  360
gtgggtgac  agttggtgg  gatctccac  atcggggat  tgacctacg  gcgtgtaag  420
aagagggtg  cttgagcca  caggctggg  tctgaggga  tgcaaccca  caataaaag  480
gcaccatgg  tcaccact  498



<210> 3027
<211> 127
<212> PRT
<213> Rattus norvegicus
<308> P80020
<400> 3027

Ala Phe Thr Gly Lys Tyr Glu Phe Glu Ser Glu Lys Asn Tyr Asp Glu 
  1               5                  10                  15
Phe Met Lys Arg Leu Gly Leu Pro Asp Glu Val Ile Glu Arg Gly Arg 
             20                  25                  30
Asn Phe Lys Ile Ile Thr Glu Val Gln Gln Asp Gly Glu Asn Phe Thr 
         35                  40                  45
Trp Ser Gln Ser Tyr Ser Gly Gly Asn Ile Met Ser Asn Lys Phe Thr 
     50                  55                  60
Ile Gly Lys Glu Cys Glu Met Gln Thr Met Gly Gly Lys Lys Phe Lys 
 65                  70                  75                  80
Ala Thr Val Lys Met Glu Gly Gly Lys Val Val Ala Asp Phe Pro Asn 
                 85                  90                  95
Tyr His Gln Thr Ser Glu Val Val Gly Asp Lys Leu Val Glu Ile Ser 
             100                105                110
Thr Ile Gly Asp Val Thr Tyr Glu Arg Val Ser Lys Arg Val Ala 
         115                120                125



<210> 3028
<211> 459
<212> DNA
<213> Homo sapiens
<308> U19869
<400> 3028

atccattct  ctcatccct  tgctctctg  cctccagcc  cccagcagc  tggctttca  60
cggcaagtt  gagatggag  gtgagaaga  ttatgatga  ttcatgaag  tccttggga  120
ctccagcga  gtaatcgaa  aggcccgca  cttcaagat  gtcacggag  tgcagcagg  180
tgggcagga  ttcacttgg  cccagcact  ctccggggg  cacaccatg  ccaacaagt  240
cactgttgg  aaggaaagc  acatacaga  aatgggggg  aagacgttc  aggccactg  300
gcagatgga  ggcgggaag  tggtggtga  tttccccaa  tatcaccag  cctcagaga  360
cgtgggtga  aagctggtg  aggtctcca  catcggagg  gtgacctat  agcgcgtga  420
caagagact  gcctaagca  ccaggcccg  cccagggag  459



<210> 3029
<211> 127
<212> PRT
<213> Homo sapiens
<308> P51161
<400> 3029

Ala Phe Thr Gly Lys Phe Glu Met Glu Ser Glu Lys Asn Tyr Asp Glu 
  1               5                  10                  15
Phe Met Lys Leu Leu Gly Ile Ser Ser Asp Val Ile Glu Lys Ala Arg 
             20                  25                  30
Asn Phe Lys Ile Val Thr Glu Val Gln Gln Asp Gly Gln Asp Phe Thr 
         35                  40                  45
Trp Ser Gln His Tyr Ser Gly Gly His Thr Met Thr Asn Lys Phe Thr 
     50                  55                  60
Val Gly Lys Glu Ser Asn Ile Gln Thr Met Gly Gly Lys Thr Phe Lys 
 65                  70                  75                  80
Ala Thr Val Gln Met Glu Gly Gly Lys Leu Val Val Asn Phe Pro Asn 
                 85                  90                  95
Tyr His Gln Thr Ser Glu Ile Val Gly Asp Lys Leu Val Glu Val Ser 
             100                105                110
Thr Ile Gly Gly Val Thr Tyr Glu Arg Val Ser Lys Arg Leu Ala 
         115                120                125



<210> 3030
<211> 1124
<212> DNA
<213> Rattus norvegicus
<308> L23148
<400> 3030

cggcacgag  taacaccct  ttctcagac  cctccgcgc  tctccgcct  tcctcagga  60
catgaaggt  gccagtagc  gtgccgcgg  caccgcagg  cccagctgt  cgctgaagg  120
aggcaggac  gcgggcgaa  tggtgcttg  tctgtcgga  caaagcgtt  ccatctcgc  180
ctgcgctgg  acgcgcctg  ccgccttgc  ggacgaaca  caggtgaac  ttctgctct  240
cgacatgaa  ggctgctac  cacgcctca  ggagctggt  cctaccctg  ctcagaacc  300
caaagtgag  aaggtggag  tactgcagc  tgttatcga  tacatcagg  acctgcagc  360
ggagctgaa  tctgagtct  aagtcgcga  cgccggagg  cgggggctg  ccgtccggg  420
cccgctcag  accctgaac  gcgagatca  tgccttggc  gccgaggtg  ggtccgagt  480
agagtatta  attattctc  tgtgggaaa  taaggccac  ggagggggg  gtccccctt  540
cttctcagg  gcatagtta  ttaggggcg  ccaatagga  aaagctcgc  ctttcatcg  600
gcctcctgg  gtagagaag  gggaatgcc  ctcccctcc  gttctttcc  gtgggtctc  660
tgccttatc  cgctctggt  ttcacaggc  gcatgtgtt  cagccgacg  ccgcatctt  720
tgtcgctga  gcggcgcac  gaggaacca  atggactcc  gcccttcag  aggcaagag  780
aaaaaaagt  ctctcggtt  cccagagca  cccggggaa  gacactacc  cggccacgg  840
actcttgac  gatctgtcc  gggggtaga  ggttgatca  cggagtctc  ccctctcca  900
ctttcagcc  ccagagact  tgaggaggg  gttattcaa  cccgtgtgt  tctgttttt  960
tgaaaaagc  gacattttt  ttaaatggt  acatttcgt  cttctcaga  ttctgagaa  1020
atgttttgt  ttgtatatt  caatgatca  tggctgaga  tattgtttt  caatagttc  1080
tatgggggt  ggttttttg  tgttattaa  caaacactt  agat  1124



<210> 3031
<211> 164
<212> PRT
<213> Rattus norvegicus
<308> P41135
<400> 3031

Met Lys Val Ala Ser Ser Ser Ala Ala Ala Thr Ala Gly Pro Ser Cys 
  1               5                  10                  15
Ser Leu Lys Ala Gly Arg Thr Ala Gly Glu Val Val Leu Gly Leu Ser 
             20                  25                  30
Glu Gln Ser Val Ala Ile Ser Arg Cys Ala Gly Thr Arg Leu Pro Ala 
         35                  40                  45
Leu Leu Asp Glu Gln Gln Val Asn Val Leu Leu Tyr Asp Met Asn Gly 
     50                  55                  60
Cys Tyr Ser Arg Leu Lys Glu Leu Val Pro Thr Leu Pro Gln Asn Arg 
 65                  70                  75                  80
Lys Val Ser Lys Val Glu Ile Leu Gln His Val Ile Asp Tyr Ile Arg 
                 85                  90                  95
Asp Leu Gln Leu Glu Leu Asn Ser Glu Ser Glu Val Ala Thr Ala Gly 
             100                105                110
Gly Arg Gly Leu Pro Val Arg Ala Pro Leu Ser Thr Leu Asn Gly Glu 
         115                120                125
Ile Ser Ala Leu Ala Ala Glu Val Arg Ser Glu Ser Glu Tyr Tyr Ile 
     130                135                140
Ile Leu Leu Trp Glu Thr Lys Ala Thr Gly Gly Gly Cys Pro Pro Tyr 
 145                150                155                160
Phe Ser Gly Ala 
                 165



<210> 3032
<211> 497
<212> DNA
<213> Homo sapiens
<308> AA689598
<400> 3032

ttttttttt  ttagacatt  taaatatct  tatattaaa  aataatagg  aattaacat  60
atttcaaca  ttcttaaag  ctcacctag  tcaacagaa  gaaattgta  caaactgtt  120
caacagaca  cagtatata  gcaatggtt  ggtctcagc  tttagaaac  actttttaa  180
tgttttgtt  cttggtcat  tcattttgg  atggaaaag  gaggaggca  gcctctgcg  240
ccctgtttt  cctaaggac  gtgcacact  accgtggtt  acacctgca  tcggggtgt  300
aggtgggct  atcttcacc  aagtgaaac  gtattatgg  gcagcactg  aggtcagct  360
cgcaagtct  tgaaagctg  cccagaaga  ccaacccac  accagaacc  tcaggctgt  420
atcacacac  tgccacaaa  catcatccc  caaaacggt  acaaaacac  agacaggcc  480
tttgtgaat  tagttgt  497



<210> 3033
<211> 1124
<212> DNA
<213> Rattus norvegicus
<308> L23148
<400> 3033

cggcacgag  taacaccct  ttctcagac  cctccgcgc  tctccgcct  tcctcagga  60
catgaaggt  gccagtagc  gtgccgcgg  caccgcagg  cccagctgt  cgctgaagg  120
aggcaggac  gcgggcgaa  tggtgcttg  tctgtcgga  caaagcgtt  ccatctcgc  180
ctgcgctgg  acgcgcctg  ccgccttgc  ggacgaaca  caggtgaac  ttctgctct  240
cgacatgaa  ggctgctac  cacgcctca  ggagctggt  cctaccctg  ctcagaacc  300
caaagtgag  aaggtggag  tactgcagc  tgttatcga  tacatcagg  acctgcagc  360
ggagctgaa  tctgagtct  aagtcgcga  cgccggagg  cgggggctg  ccgtccggg  420
cccgctcag  accctgaac  gcgagatca  tgccttggc  gccgaggtg  ggtccgagt  480
agagtatta  attattctc  tgtgggaaa  taaggccac  ggagggggg  gtccccctt  540
cttctcagg  gcatagtta  ttaggggcg  ccaatagga  aaagctcgc  ctttcatcg  600
gcctcctgg  gtagagaag  gggaatgcc  ctcccctcc  gttctttcc  gtgggtctc  660
tgccttatc  cgctctggt  ttcacaggc  gcatgtgtt  cagccgacg  ccgcatctt  720
tgtcgctga  gcggcgcac  gaggaacca  atggactcc  gcccttcag  aggcaagag  780
aaaaaaagt  ctctcggtt  cccagagca  cccggggaa  gacactacc  cggccacgg  840
actcttgac  gatctgtcc  gggggtaga  ggttgatca  cggagtctc  ccctctcca  900
ctttcagcc  ccagagact  tgaggaggg  gttattcaa  cccgtgtgt  tctgttttt  960
tgaaaaagc  gacattttt  ttaaatggt  acatttcgt  cttctcaga  ttctgagaa  1020
atgttttgt  ttgtatatt  caatgatca  tggctgaga  tattgtttt  caatagttc  1080
tatgggggt  ggttttttg  tgttattaa  caaacactt  agat  1124



<210> 3034
<211> 164
<212> PRT
<213> Rattus norvegicus
<308> P41135
<400> 3034

Met Lys Val Ala Ser Ser Ser Ala Ala Ala Thr Ala Gly Pro Ser Cys 
  1               5                  10                  15
Ser Leu Lys Ala Gly Arg Thr Ala Gly Glu Val Val Leu Gly Leu Ser 
             20                  25                  30
Glu Gln Ser Val Ala Ile Ser Arg Cys Ala Gly Thr Arg Leu Pro Ala 
         35                  40                  45
Leu Leu Asp Glu Gln Gln Val Asn Val Leu Leu Tyr Asp Met Asn Gly 
     50                  55                  60
Cys Tyr Ser Arg Leu Lys Glu Leu Val Pro Thr Leu Pro Gln Asn Arg 
 65                  70                  75                  80
Lys Val Ser Lys Val Glu Ile Leu Gln His Val Ile Asp Tyr Ile Arg 
                 85                  90                  95
Asp Leu Gln Leu Glu Leu Asn Ser Glu Ser Glu Val Ala Thr Ala Gly 
             100                105                110
Gly Arg Gly Leu Pro Val Arg Ala Pro Leu Ser Thr Leu Asn Gly Glu 
         115                120                125
Ile Ser Ala Leu Ala Ala Glu Val Arg Ser Glu Ser Glu Tyr Tyr Ile 
     130                135                140
Ile Leu Leu Trp Glu Thr Lys Ala Thr Gly Gly Gly Cys Pro Pro Tyr 
 145                150                155                160
Phe Ser Gly Ala 
                 165



<210> 3035
<211> 497
<212> DNA
<213> Homo sapiens
<308> AA689598
<400> 3035

ttttttttt  ttagacatt  taaatatct  tatattaaa  aataatagg  aattaacat  60
atttcaaca  ttcttaaag  ctcacctag  tcaacagaa  gaaattgta  caaactgtt  120
caacagaca  cagtatata  gcaatggtt  ggtctcagc  tttagaaac  actttttaa  180
tgttttgtt  cttggtcat  tcattttgg  atggaaaag  gaggaggca  gcctctgcg  240
ccctgtttt  cctaaggac  gtgcacact  accgtggtt  acacctgca  tcggggtgt  300
aggtgggct  atcttcacc  aagtgaaac  gtattatgg  gcagcactg  aggtcagct  360
cgcaagtct  tgaaagctg  cccagaaga  ccaacccac  accagaacc  tcaggctgt  420
atcacacac  tgccacaaa  catcatccc  caaaacggt  acaaaacac  agacaggcc  480
tttgtgaat  tagttgt  497



<210> 3036
<211> 2897
<212> DNA
<213> Rattus norvegicus
<308> L23219
<400> 3036

aggcaccaa  ccctagttt  ccggggcct  cggagcagc  ggctgaggg  tcctgtcgc  60
gcctgggcc  ggtgtgacc  cccgtccac  cagacccag  caccagcct  gcaccctgc  120
gtgccaaat  aatgcacag  atttctctt  cagggtgtg  agccttcct  ttggaacct  180
ggtgctggg  cagtgggac  cagagcagc  ctctagacg  caggtccac  ctcatggct  240
atgatgtca  gtactaaca  cgtcgccca  gcccggaag  tggtggagc  gttgcgcat  300
gaagctggg  tcgaacgca  caaggtctc  aaggcctcg  cagaactga  gagctactg  360
gagcaacat  cccggaatg  ccccttgct  gttggtgta  cagcctctg  aaatccatt  420
aaagacaaa  agccttgca  aattctcta  ttctctctc  cttcctccc  ccttcctct  480
cctctcttt  tccccaccc  aaaggtatt  tccagtttt  cctgtaaga  aaaaatatt  540
gaatccctt  tactttgaa  tttaaagga  cagaaacca  tgtgaatgc  tggagcctc  600
tgacctagc  ggagttcgt  ctggcctaa  tttagcctc  tccaccccc  cccgtcgag  660
accactgat  tgacagttt  taagctccc  ttagttggc  tggggaaag  gttctgttg  720
ccaacggcg  gcctagcaa  tttgcggac  atagctgca  tcctcgggt  ccacataaa  780
catgcaggt  cggtgtcag  aggctgaga  ggaaggatc  ccgaggctt  gggactgca  840
cctagcagc  agtaaactc  agacagtga  aaacgatgc  tccaaacac  aggcagagg  900
ggataccca  ccttgacct  tggctccac  cgcggcaca  acaatgcac  ctgtactac  960
cagtgtcat  ctcgagtgg  cctgtcgtg  gcacggtga  agtgatgcc  tttctccag  1020
gagttggcc  attctagaa  cgggcattt  ggtctccat  caaaggaag  acttgctgg  1080
atggccgag  gtgtaactt  gtctccgaa  cctgagatc  atgtgttca  tggtgactc  1140
tcgtttttc  cccagttac  cagatggtt  tgagggcag  agtgcagat  taattatct  1200
gaggtgatt  agaaggacc  atggggttc  ccatcccac  cgtgactgt  cctccagat  1260
ccccttcct  ggtcaaact  ttttttaac  aactagaac  caagtccct  aatgtgtgg  1320
ctgtggcca  tttctgcac  ccttcattg  gagattcat  tctgaccac  cccccaacc  1380
ctcactgag  gattctaga  ggggctcca  ccctgacca  gccccagtc  cccattgag  1440
gattctaga  ggggttcca  ctctgacca  gcctcagcc  cctactggg  attctagaa  1500
gggctccac  ctgaccacg  ccccagacc  ttactggta  attctagat  gcactccac  1560
tctgaggcg  gcatcttct  tattgtgtg  gcagagccc  agagtccag  ctggcctgg  1620
ctggaactg  agatcttcc  gcctctggc  ccggagtac  tacctgata  gcctgtgtt  1680
catgcctgg  atcggattg  acggaagat  acagaccgt  tgtctatga  agtgacagt  1740
gcaggtcta  ggaggacac  gcttaggtg  gccagtgtg  tctgcagcc  tacacaaag  1800
catctcaag  atttgagac  ccagttacc  ctttctcct  ccggatcag  gtgggagca  1860
aaatgaagc  agtccagtt  ctccctgca  ctctggtgg  aatctgctt  ccaaaccct  1920
tgccaggct  atccctgga  agttgctca  actgcccat  ggcaaagtg  atggagctg  1980
cagatctgg  tcctagcct  ttaggcaca  cctaccacc  agataaggt  gcagccccc  2040
ccctcccca  tccatttga  ggaatcagg  aaagaagtt  gggatgtga  taaggggga  2100
gggcactgc  ggtgctaag  gaggaccct  tttccccct  catgggcca  agagagcac  2160
gaccaaggg  caggcccct  ctgtgcact  actcccaat  actggtcag  gagggccag  2220
actttggtg  gcctgactc  cagaacctg  ggtggaatc  gaaaagcca  tgtccctcc  2280
gaactgcag  cacctttca  taggctagg  accaggtcc  agcaggtgt  tctccagct  2340
cactggcag  ggacagtga  gagagagga  aggacatac  ttctgggga  cgggactgc  2400
gaacaccca  ccagtatgg  agaaacctg  gttccaccc  aagctcgca  aaaaacagg  2460
atgggcact  gggatgtag  ggcaggaag  tcagaactt  agggtcttt  tcagccaca  2520
gatgggctc  aggttagcc  gggctgcat  agaccatgt  tcaaagaca  aaatctcag  2580
gtgctctct  atgttccta  cacgcctga  tgtttccct  tggaggctg  tgtgccagc  2640
tggccagcc  gcgtttggt  gcagccttg  ttctcagct  tgggacaaa  actcaaatc  2700
gcatctctg  ccacacctc  agttccccc  ccccgggtg  ctcacaggc  aaggacaaa  2760
tggcctctt  ctcccaggg  gggtaggat  tgctggtgt  gcctgtgta  gtcctaagc  2820
ctggagccc  gcctcggcc  agagacgct  agggaaacc  gaacacatc  gagcaatta  2880
gagccaaga  tggtggc  2897



<210> 3037
<211> 69
<212> PRT
<213> Rattus norvegicus
<308> P43425
<400> 3037

Met Met Ser Gly Thr Asn Asn Val Ala Gln Ala Arg Lys Leu Val Glu 
  1               5                  10                  15
Gln Leu Arg Ile Glu Ala Gly Ile Glu Arg Ile Lys Val Ser Lys Ala 
             20                  25                  30
Ser Ser Glu Leu Met Ser Tyr Cys Glu Gln His Ala Arg Asn Asp Pro 
         35                  40                  45
Leu Leu Val Gly Val Pro Ala Ser Glu Asn Pro Phe Lys Asp Lys Lys 
     50                  55                  60
Pro Cys Ile Ile Leu 
 65



<210> 3038
<211> 992
<212> DNA
<213> Homo sapiens
<308> BC014466
<400> 3038

gcgggccgg  gcggagggt  cggctgcgc  gcggggctg  ggcggccgc  gggcccgag  60
gcagggagt  gagcttggt  tcgggatct  ggtgctgca  acggcgaga  ctcctgcac  120
gggtgtaca  caagctgtg  ttcctggga  aactaaaaa  gctctctgg  caacggggc  180
cagagctga  ggcagacaa  gtcagccac  aacaacata  cccaggccc  gaagctggt  240
gaacagcta  gcatagaag  cgggattga  cgcatcaag  tctccaaag  ggcgtctga  300
ctcatgagc  actgtgagc  acatgcccg  aacgacccc  tgctggtcg  agtccctgc  360
tcggagaac  cctttaagg  caagaaacc  tgtattatt  tataactgt  ttctcatat  420
ttctctctc  ctctctctc  ttctctctc  ctctctgtc  ctgtctctg  ctcaggcag  480
gcatcattc  gtaattagc  caaacaaaa  atctcaagt  cccaaaacc  ttaattcca  540
aagaaatcc  ccctctccc  gccaaaaaa  gcgttccca  cgcccggat  gggtagaat  600
gaccttgta  gtggagatg  attttcagg  ccgacccca  ggccctctc  gtttgggcc  660
aaagggatg  aggctttac  gccacttcc  gttcggaat  actgaaatc  cccagcgat  720
gggtaacaa  tttttaaaa  tctcgattg  cgtttcaat  gtggaccgg  gccgagggg  780
aaagggagg  gacttcgcc  ggtggcaat  gttccggga  aattggcca  tggtaaaaa  840
acttcatag  gtcactgga  tgctttgtg  tgtttttaa  tagaggtaa  attgagatg  900
ggggcggga  gtgacatca  gaagttttt  ggaaatatc  ctttattta  aaaattgtt  960
ctccatacg  ctaaaaaaa  aaaaaaaaa  aa  992



<210> 3039
<211> 68
<212> PRT
<213> Homo sapiens
<308> O60262
<400> 3039

Met Ser Ala Thr Asn Asn Ile Ala Gln Ala Arg Lys Leu Val Glu Gln 
  1               5                  10                  15
Leu Arg Ile Glu Ala Gly Ile Glu Arg Ile Lys Val Ser Lys Ala Ala 
             20                  25                  30
Ser Asp Leu Met Ser Tyr Cys Glu Gln His Ala Arg Asn Asp Pro Leu 
         35                  40                  45
Leu Val Gly Val Pro Ala Ser Glu Asn Pro Phe Lys Asp Lys Lys Pro 
     50                  55                  60
Cys Ile Ile Leu 
 65



<210> 3040
<211> 2221
<212> DNA
<213> Rattus norvegicus
<308> L24051
<400> 3040

ggagatttt  cacaagaaa  ggttgtttt  atgtttggg  tccaggaaa  catccaacg  60
agtggaagc  gtatgaagg  agagccgct  ggcagcggc  tgaacgcgg  gcggacgtg  120
atgcagggc  ccggggtgc  ggacgccaa  acagcggcg  agagcgggg  gggtctggc  180
cgggctcac  ttgagaagc  gccgccttc  aacctgcgg  aatccaact  cttccactt  240
gtcctggcc  tctacgaca  acagggcca  cccgtggag  ttgagagga  ggcctttgt  300
gggttcgtg  agaaggaaa  agaagccaa  agcgaaaag  ccaataatg  gatccacta  360
cggctccag  tcctctaca  caatgggat  aggaccgaa  aggatttct  cgtgcgcct  420
atcgactcc  tgacaaaac  agccatagt  tatgaaggc  aagacaaga  cccggaaat  480
tgccgagta  tgctcacac  cgagatcat  tgcagccgc  gttgtgaca  gaaaagctg  540
ggcaaccga  atgagactc  ctcagatcc  gtgataatt  acagattct  cctgaagtt  600
ttccttaag  gtaaccaaa  ttgcctaaa  aatgcgggg  acccacgtg  catgcggag  660
ttccaggtc  tggtgtcta  cacagtcaa  gtggatggc  atgtcctgg  agtctctga  720
aacatgttt  tccacaata  ctccaaaca  gggcggagg  ctaggaggc  tgacccctc  780
gaagcagct  ctccctgta  caaagccat  agcccgagt  aaggatgga  gacgggagg  840
gcgactgtg  tcatcatag  ggacaattt  tttgatggg  tacaggtca  attcggtac  900
atgctggtc  ggagtgagt  gataactcc  catgccatc  gtgttcaga  acctcctcg  960
cacatccct  gtgttgtgg  agtcacatt  tcctacaag  ccaagcagt  ctgcaaagg  1020
acaccaggc  gattcatct  tacagcact  aatgaaccc  ccatcgact  tggtttcca  1080
aggttacag  aggtcattc  ccggcatcc  ggtgaccca  agcgtttgc  aaaggaagt  1140
atccttaaa  gggctgcag  tctggttga  gccctgtat  ggatgcccc  caacaacca  1200
gagattatc  tgaagagag  tgccgacat  gctgaggct  tgtacagtg  ccctcgaaa  1260
cacaaccag  tcccggccc  cgctaacac  tcggtccac  cagggatga  gggcgtgaa  1320
tccttcagt  gacaactgg  tgtgaatgt  tctgaggca  cacaagcca  caatcaagg  1380
ttcacccgc  actcaagca  tgtgtcacc  catggatat  tgcctagca  caccccaca  1440
cagaccaac  ataactctg  caccacaag  atgaacggc  acggctctg  cgccatgtc  1500
aatttgggc  gctccccaa  cttcctcaa  ggctcagct  ccaactcac  ctacgccat  1560
gtgccatcc  gccccacca  ggcctcatc  acaagcctc  cctccaact  cagcagctc  1620
tcgggcatc  tctccttct  accagccaa  atggtctct  ctgtgaaac  gaagagtgc  1680
ttcgcacca  ttgtcagac  ccagacctc  ccgcctccc  cctgcacca  caccaacgg  1740
aacagcctg  aagcgattt  tggcatgat  gtccctccc  tgtgaaaga  ttgccttga  1800
gaattttat  aatgaagag  ttggatcct  ctacgaaag  aatctgaca  gagtcccag  1860
gtggaactt  taactcagg  ctttttaag  ggaaatcac  caataactg  agattttta  1920
acaaagtca  cgaccttgc  aatactgag  ttggaaagg  gacctgcca  agcggggtg  1980
tggatagag  cggactccc  gagtgtctg  gggatatat  tattctgta  tgataaaaa  2040
aagaacaag  ccacctttt  tttttttct  tctcttttc  ttctttaag  ttaactctg  2100
aaccatttg  cttttgtaa  ccattaagc  acacacaag  gccactcta  ataagactc  2160
atgttttaa  ttatgatgt  tttaaagct  tgtaagggg  gaatgaagt  gtgatattt  2220
c  2221



<210> 3041
<211> 584
<212> PRT
<213> Rattus norvegicus
<308> Q63398
<400> 3041

Met Phe Gly Ile Gln Glu Ser Ile Gln Arg Ser Gly Ser Ser Met Lys 
  1               5                  10                  15
Glu Glu Pro Leu Gly Ser Gly Met Asn Ala Val Arg Thr Trp Met Gln 
             20                  25                  30
Gly Ala Gly Val Leu Asp Ala Asn Thr Ala Ala Gln Ser Gly Val Gly 
         35                  40                  45
Leu Ala Arg Ala His Phe Glu Lys Gln Pro Pro Ser Asn Leu Arg Lys 
     50                  55                  60
Ser Asn Phe Phe His Phe Val Leu Ala Leu Tyr Asp Arg Gln Gly Gln 
 65                  70                  75                  80
Pro Val Glu Ile Glu Arg Thr Ala Phe Val Gly Phe Val Glu Lys Glu 
                 85                  90                  95
Lys Glu Ala Asn Ser Glu Lys Thr Asn Asn Gly Ile His Tyr Arg Leu 
             100                105                110
Gln Leu Leu Tyr Ser Asn Gly Ile Arg Thr Glu Gln Asp Phe Tyr Val 
         115                120                125
Arg Leu Ile Asp Ser Met Thr Lys Gln Ala Ile Val Tyr Glu Gly Gln 
     130                135                140
Asp Lys Asn Pro Glu Met Cys Arg Val Leu Leu Thr His Glu Ile Met 
 145                150                155                160
Cys Ser Arg Cys Cys Asp Lys Lys Ser Cys Gly Asn Arg Asn Glu Thr 
                 165                170                175
Pro Ser Asp Pro Val Ile Ile Asp Arg Phe Phe Leu Lys Phe Phe Leu 
             180                185                190
Lys Cys Asn Gln Asn Cys Leu Lys Asn Ala Gly Asn Pro Arg Asp Met 
         195                200                205
Arg Arg Phe Gln Val Val Val Ser Thr Thr Val Asn Val Asp Gly His 
     210                215                220
Val Leu Ala Val Ser Asp Asn Met Phe Val His Asn Asn Ser Lys His 
 225                230                235                240
Gly Arg Arg Ala Arg Arg Leu Asp Pro Ser Glu Ala Ala Thr Pro Cys 
                 245                250                255
Ile Lys Ala Ile Ser Pro Ser Glu Gly Trp Thr Thr Gly Gly Ala Thr 
             260                265                270
Val Ile Ile Ile Gly Asp Asn Phe Phe Asp Gly Leu Gln Val Ile Phe 
         275                280                285
Gly Thr Met Leu Val Trp Ser Glu Leu Ile Thr Pro His Ala Ile Arg 
     290                295                300
Val Gln Thr Pro Pro Arg His Ile Pro Gly Val Val Glu Val Thr Leu 
 305                310                315                320
Ser Tyr Lys Ser Lys Gln Phe Cys Lys Gly Thr Pro Gly Arg Phe Ile 
                 325                330                335
Tyr Thr Ala Leu Asn Glu Pro Thr Ile Asp Tyr Gly Phe Gln Arg Leu 
             340                345                350
Gln Lys Val Ile Pro Arg His Pro Gly Asp Pro Glu Arg Leu Pro Lys 
         355                360                365
Glu Val Ile Leu Lys Arg Ala Ala Asp Leu Val Glu Ala Leu Tyr Gly 
     370                375                380
Met Pro His Asn Asn Gln Glu Ile Ile Leu Lys Arg Ala Ala Asp Ile 
 385                390                395                400
Ala Glu Ala Leu Tyr Ser Val Pro Arg Asn His Asn Gln Leu Pro Ala 
                 405                410                415
Leu Ala Asn Thr Ser Val His Ala Gly Met Met Gly Val Asn Ser Phe 
             420                425                430
Ser Gly Gln Leu Ala Val Asn Val Ser Glu Ala Ser Gln Ala Thr Asn 
         435                440                445
Gln Gly Phe Thr Arg Asn Ser Ser Ser Val Ser Pro His Gly Tyr Val 
     450                455                460
Pro Ser Thr Thr Pro Gln Gln Thr Asn Tyr Asn Ser Val Thr Thr Ser 
 465                470                475                480
Met Asn Gly Tyr Gly Ser Ala Ala Met Ser Asn Leu Gly Gly Ser Pro 
                 485                490                495
Thr Phe Leu Asn Gly Ser Ala Ala Asn Ser Pro Tyr Ala Ile Val Pro 
             500                505                510
Ser Ser Pro Thr Met Ala Ser Ser Thr Ser Leu Pro Ser Asn Cys Ser 
         515                520                525
Ser Ser Ser Gly Ile Phe Ser Phe Ser Pro Ala Asn Met Val Ser Ala 
     530                535                540
Val Lys Gln Lys Ser Ala Phe Ala Pro Val Val Arg Pro Gln Thr Ser 
 545                550                555                560
Pro Pro Pro Thr Cys Thr Ser Thr Asn Gly Asn Ser Leu Gln Ala Ile 
                 565                570                575
Ser Gly Met Ile Val Pro Pro Met 
             580



<210> 3042
<211> 874
<212> DNA
<213> Homo sapiens
<308> BG535341
<400> 3042

atgggcgga  ggctcggag  cttgacccc  cggaagcta  tccctgtat  aaagccatc  60
gcccgagtg  aggatggac  acgggaggt  cgactgtga  catcatagg  gggaattag  120
ccgagtgga  agagcgagc  gagtggttg  gtggtcgcg  ctcggaaac  ggtagcgct  180
gcagcatgg  tgaccaact  actgaagag  agattgcag  attcaaaga  gctttttca  240
tatttgaca  agatggtga  ggaactata  caacaaagg  attgggaac  gtaatgaga  300
ctcttgggc  gaatcccac  gaagcagag  tacaggaca  gattaatga  gtagatgct  360
atggtaatg  cacaattga  ttccctgaa  ttctgacaa  gatggcaag  aaaatgaaa  420
acacagaca  tgaagaaga  attagagaa  cattccgtg  gtttgataa  gatggcaat  480
gctatatta  tgctgcaga  cttcgccat  tgatgacaa  ccttggaga  aaagttaac  540
gatgacgaa  ttgatgaaa  gatcaggga  gcagatatt  atggttgat  gtcaagtaa  600
ctatgaaga  ttgtacaaa  gatgacagc  agtgaagac  tgtcagaat  tgttaacat  660
cctgtacaa  ctggtcact  tgccttttc  atggtgggt  acttattcg  taacaaggg  720
tgtcttacc  aacggtcaa  aaactctgc  tgtatagta  ttaggactc  cattcctcc  780
tggtgtctt  cccttatct  acgggccat  cccctaaag  gtatttagc  acactgggc  840
cgttagctg  ctggcagtg  ctacctcgg  gaca  874



<210> 3043
<211> 148
<212> PRT
<213> Homo sapiens
<308> P02593
<400> 3043

Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala Phe 
  1               5                  10                  15
Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu Leu 
             20                  25                  30
Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu 
         35                  40                  45
Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile Asp 
     50                  55                  60
Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr Asp 
 65                  70                  75                  80
Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly 
                 85                  90                  95
Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn Leu 
             100                105                110
Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala 
         115                120                125
Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met 
     130                135                140
Met Thr Ala Lys 
 145



<210> 3044
<211> 2015
<212> DNA
<213> Rattus norvegicus
<308> L24207
<400> 3044

gcagagcat  agaggccca  ctagaggga  aacacagag  agtaatttg  tgacagacc  60
gcagggatg  acctgcttt  agctctcac  ctggaaacc  gggtcctcc  ggcagtcgt  120
ctggtgctc  tctacggat  tgggacccg  acacatgga  ttttcaaga  acaggggat  180
cctgggccc  aacctctgc  tttttttgg  actgtgctg  attactata  gggtttatg  240
aaattcgat  tggagtgcc  taaaaagta  ggaaaaata  gggggttgt  tgatggtca  300
atgcctctg  ttgccatca  ggacacaga  atgatcaag  atgtgctag  gaaggaatg  360
ttttctgtc  tcacaaacc  gcgggattt  ggcccagtg  ggattatgg  gaaagccat  420
tctgtatct  aggatgagg  gtggaagag  tatagagcc  tactgtcac  cacgttcac  480
agtggaaga  tcaaggaga  gttccctgt  atcgaacag  atggagaca  tttggtaaa  540
tacttgagg  aagagaaag  caaacctgt  cctgtgaaa  aagtgtttg  tgcctacag  600
atggatgtg  tcaccagca  atcatttgg  gtgaatgtt  attccctca  caacccgaa  660
gatcctttt  tggagaaag  caagaagct  ttaagaatt  atttttttg  tccgttgtt  720
ttgtcagta  tactctttc  attcctcac  ccagtatat  agatgttaa  catctgcat  780
ttcccaaaa  attcaatag  atttttcaa  aaatttgtg  acagaatga  ggaaacccg  840
ctggattct  tgcagaagc  tcgagtgga  tttcttcag  tgatgatga  tgctcataa  900
gattctaaa  acaaagaat  tcatacagc  ctatccgat  tggagatca  agcccagtc  960
atcattttt  tttttgctg  atatgaacc  accagcagc  cactttcct  tgtcctgca  1020
tccctggcc  ctcacccag  tacacagaa  aaactgcag  aggagatcg  cagggctct  1080
cccaataag  cacctccca  ctatgatac  gtgatggaa  tggaatacc  ggatatggt  1140
ttgaatgaa  ccctcagat  gtatccaat  ggtaataga  ttgagagag  ctgtaaaaa  1200
gatgttgaa  tcaatggtg  gtttatgcc  aaagggtca  tggtcatga  tccatctta  1260
gctcttcac  gtgatccac  gcactggcc  gagcctgag  aatttcgcc  agaaaggtt  1320
agcaaggag  acaagggca  cattgatcc  tatgtatat  tgccctttg  aaatggacc  1380
aggaactgc  ttggcatga  gtttgctct  atgaatatg  aactcgctc  cactaaagt  1440
ctgcaaaac  tctccttcc  gccttgtaa  gaaacacag  tacctctga  attaagcag  1500
caaggactt  ttcaaccaa  aaaacccat  attctaaag  ttgtgccac  ggatgaaat  1560
ataactgga  catgatttt  cctcaagga  ttctgctga  ttcgtcaga  atgtggtgt  1620
taagaacac  agacccttt  atttatgtc  tgaataaaa  tcagatgaa  ttagggctt  1680
atcgacttt  ttttgattc  gtacatctt  gatctttct  agtgtctac  atgtaccca  1740
ctaatataa  ggaaatgac  agtcagtga  agaacagga  ttaaccttt  gtgattctc  1800
tgggactac  tccatttgt  tctggttgt  tctgttaat  tcttttgat  gtaaccttg  1860
ctctgtaat  tgatcaaga  ttttcatga  aatgtgaac  attgtgaca  ctttaattg  1920
agatttggt  tcagatgtt  tagatgcat  attctacac  aaatgttac  tggaaaaaa  1980
gtgaataaa  acttcttta  aaatcccca  gggca  2015



<210> 3045
<211> 504
<212> PRT
<213> Rattus norvegicus
<308> P04800
<400> 3045

Met Asp Leu Leu Ser Ala Leu Thr Leu Glu Thr Trp Val Leu Leu Ala 
  1               5                  10                  15
Val Val Leu Val Leu Leu Tyr Gly Phe Gly Thr Arg Thr His Gly Leu 
             20                  25                  30
Phe Lys Lys Gln Gly Ile Pro Gly Pro Lys Pro Leu Pro Phe Phe Gly 
         35                  40                  45
Thr Val Leu Asn Tyr Tyr Met Gly Leu Trp Lys Phe Asp Val Glu Cys 
     50                  55                  60
His Lys Lys Tyr Gly Lys Ile Trp Gly Leu Phe Asp Gly Gln Met Pro 
 65                  70                  75                  80
Leu Phe Ala Ile Thr Asp Thr Glu Met Ile Lys Asn Val Leu Val Lys 
                 85                  90                  95
Glu Cys Phe Ser Val Phe Thr Asn Arg Arg Asp Phe Gly Pro Val Gly 
             100                105                110
Ile Met Gly Lys Ala Val Ser Val Ala Lys Asp Glu Glu Trp Lys Arg 
         115                120                125
Tyr Arg Ala Leu Leu Ser Pro Thr Phe Thr Ser Gly Arg Leu Lys Glu 
     130                135                140
Met Phe Pro Ile Ile Glu Gln Tyr Gly Asp Ile Leu Val Lys Tyr Leu 
 145                150                155                160
Lys Gln Glu Ala Glu Thr Gly Lys Pro Val Thr Met Lys Lys Val Phe 
                 165                170                175
Gly Ala Tyr Ser Met Asp Val Ile Thr Ser Thr Ser Phe Gly Val Asn 
             180                185                190
Val Asp Ser Leu Asn Asn Pro Lys Asp Pro Phe Val Glu Lys Thr Lys 
         195                200                205
Lys Leu Leu Arg Phe Asp Phe Phe Asp Pro Leu Phe Leu Ser Val Val 
     210                215                220
Leu Phe Pro Phe Leu Thr Pro Ile Tyr Glu Met Leu Asn Ile Cys Met 
 225                230                235                240
Phe Pro Lys Asp Ser Ile Glu Phe Phe Lys Lys Phe Val Tyr Arg Met 
                 245                250                255
Lys Glu Thr Arg Leu Asp Ser Val Gln Lys His Arg Val Asp Phe Leu 
             260                265                270
Gln Leu Met Met Asn Ala His Asn Asp Ser Lys Asp Lys Glu Ser His 
         275                280                285
Thr Ala Leu Ser Asp Met Glu Ile Thr Ala Gln Ser Ile Ile Phe Ile 
     290                295                300
Phe Ala Gly Tyr Glu Pro Thr Ser Ser Thr Leu Ser Phe Val Leu His 
 305                310                315                320
Ser Leu Ala Thr His Pro Asp Thr Gln Lys Lys Leu Gln Glu Glu Ile 
                 325                330                335
Asp Arg Ala Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Thr Val Met 
             340                345                350
Glu Met Glu Tyr Leu Asp Met Val Leu Asn Glu Thr Leu Arg Leu Tyr 
         355                360                365
Pro Ile Gly Asn Arg Leu Glu Arg Val Cys Lys Lys Asp Val Glu Ile 
     370                375                380
Asn Gly Val Phe Met Pro Lys Gly Ser Val Val Met Ile Pro Ser Tyr 
 385                390                395                400
Ala Leu His Arg Asp Pro Gln His Trp Pro Glu Pro Glu Glu Phe Arg 
                 405                410                415
Pro Glu Arg Phe Ser Lys Glu Asn Lys Gly Ser Ile Asp Pro Tyr Val 
             420                425                430
Tyr Leu Pro Phe Gly Asn Gly Pro Arg Asn Cys Ile Gly Met Arg Phe 
         435                440                445
Ala Leu Met Asn Met Lys Leu Ala Leu Thr Lys Val Leu Gln Asn Phe 
     450                455                460
Ser Phe Gln Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Ser Arg 
 465                470                475                480
Gln Gly Leu Leu Gln Pro Thr Lys Pro Ile Ile Leu Lys Val Val Pro 
                 485                490                495
Arg Asp Glu Ile Ile Thr Gly Ser 
             500



<210> 3046
<211> 1707
<212> DNA
<213> Homo sapiens
<308> J04813
<400> 3046

gggaagctc  aggcaaaca  cccagcaaa  agcagcact  agctaaaag  aagactcac  60
gaacacagt  gaagaagga  agtggcgat  gacctcatc  caaatttgg  ggtggaaac  120
tggcttctc  tggctgtca  cctggtgct  ctctatcta  atgggaccc  tacacatgg  180
ctttttaag  gactgggaa  tccagggcc  acacctctg  ctttgttgg  aaatgtttt  240
tcctatcgt  agggtctct  gaaatttga  acagagtgc  ataaaaagt  tggaaaaat  300
tggggaacg  atgaaggtc  actccctgt  ctggccatc  cagatcccg  cgtgatcag  360
acagtgcta  tgaaagaat  ttattctgt  ttcacaaat  gaaggtctt  aggcccagt  420
ggatttatg  aaagtgcca  ctctttagc  gaggatgaa  aatggaaga  aatacggtc  480
ttgctgtct  caaccttca  cagcggaaa  ctcaaggag  tgttcccca  cattgccca  540
tatggagat  tattggtga  aaacttgag  cgggaagca  agaaaggca  gcctgtcac  600
ttgaaagac  tctttgggg  ctacagcat  gatgtgatt  ctggcacat  atttggagt  660
aacatcgac  ctctcaaca  tccacaaga  ccctttgtg  agagcacta  gaagttcct  720
aaatttggt  tcttagatc  attatttct  tcaataata  tctttccat  ccttacccc  780
gtttttgaa  cattaaatg  ctctctgtt  ccaaaagat  ccataaatt  tttaagtaa  840
tctgtaaac  gaatgaaga  aagtcgcct  aacgacaaa  aaaagcacc  actagattt  900
cttcagctg  tgattgact  ccagaattc  aaagaaact  agtcccaca  agctctgtc  960
gatctggag  tcgcagccc  gtcaataat  ttcattttt  ctggctatg  aaccaccag  1020
agtgttctt  ccttcactt  atatgaact  gccactcac  ctgatgtcc  gcagaaact  1080
caaaaggag  ttgatgcag  tttgcccaa  aaggcacca  ctacctatg  tgccgtggt  1140
cagatggag  accttgaca  ggtggtgaa  gaaacactc  gattattcc  agttgctat  1200
agacttgag  ggacttgca  gaaagatgt  gaaatcaat  gggtattca  tcccaaagg  1260
tcaatggtg  tgattccaa  ttatgctct  caccatgac  caaagtact  gacagagcc  1320
gaggagttc  gccctgaaa  gttcagtaa  aagaaggac  gcatagatc  ttacatata  1380
acacccttt  gaactggac  cagaaactg  attggcatg  ggtttgctc  catgaacat  1440
aaacttgct  taatcagag  ccttcagaa  ttctccttc  aaccttgta  agaaacaca  1500
atccccttg  aattagaca  gcaaggact  cttcaacca  aaaaaccca  tgttctaaa  1560
gtggattca  gagatggaa  cctaagtgg  gaatgagtt  ttctaagga  ttctacttt  1620
gtcttcaag  aagctgtgc  ccagaacac  agagatttc  acttagtca  taaaacctt  1680
aaataaaga  gggcttaat  taatgta  1707



<210> 3047
<211> 502
<212> PRT
<213> Homo sapiens
<308> P20815
<400> 3047

Met Asp Leu Ile Pro Asn Leu Ala Val Glu Thr Trp Leu Leu Leu Ala 
  1               5                  10                  15
Val Ser Leu Val Leu Leu Tyr Leu Tyr Gly Thr Arg Thr His Gly Leu 
             20                  25                  30
Phe Lys Arg Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly 
         35                  40                  45
Asn Val Leu Ser Tyr Arg Gln Gly Leu Trp Lys Phe Asp Thr Glu Cys 
     50                  55                  60
Tyr Lys Lys Tyr Gly Lys Met Trp Gly Thr Tyr Glu Gly Gln Leu Pro 
 65                  70                  75                  80
Val Leu Ala Ile Thr Asp Pro Asp Val Ile Arg Thr Val Leu Val Lys 
                 85                  90                  95
Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Ser Leu Gly Pro Val Gly 
             100                105                110
Phe Met Lys Ser Ala Ile Ser Leu Ala Glu Asp Glu Glu Trp Lys Arg 
         115                120                125
Ile Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
     130                135                140
Met Phe Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
 145                150                155                160
Arg Arg Glu Ala Glu Lys Gly Lys Pro Val Thr Leu Lys Asp Ile Phe 
                 165                170                175
Gly Ala Tyr Ser Met Asp Val Ile Thr Gly Thr Ser Phe Gly Val Asn 
             180                185                190
Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Ser Thr Lys 
         195                200                205
Lys Phe Leu Lys Phe Gly Phe Leu Asp Pro Leu Phe Leu Ser Ile Ile 
     210                215                220
Leu Phe Pro Phe Leu Thr Pro Val Phe Glu Ala Leu Asn Val Ser Leu 
 225                230                235                240
Phe Pro Lys Asp Thr Ile Asn Phe Leu Ser Lys Ser Val Asn Arg Met 
                 245                250                255
Lys Lys Ser Arg Leu Asn Asp Lys Gln Lys His Arg Leu Asp Phe Leu 
             260                265                270
Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Glu Ser His Lys 
         275                280                285
Ala Leu Ser Asp Leu Glu Leu Ala Ala Gln Ser Ile Ile Phe Ile Phe 
     290                295                300
Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Thr Leu Tyr Glu 
 305                310                315                320
Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Lys Glu Ile Asp 
                 325                330                335
Ala Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Ala Val Val Gln 
             340                345                350
Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
         355                360                365
Val Ala Ile Arg Leu Glu Arg Thr Cys Lys Lys Asp Val Glu Ile Asn 
     370                375                380
Gly Val Phe Ile Pro Lys Gly Ser Met Val Val Ile Pro Thr Tyr Ala 
 385                390                395                400
Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Glu Phe Arg Pro 
                 405                410                415
Glu Arg Phe Ser Lys Lys Lys Asp Ser Ile Asp Pro Tyr Ile Tyr Thr 
             420                425                430
Pro Phe Gly Thr Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala Leu 
         435                440                445
Met Asn Met Lys Leu Ala Leu Ile Arg Val Leu Gln Asn Phe Ser Phe 
     450                455                460
Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Asp Thr Gln Gly 
 465                470                475                480
Leu Leu Gln Pro Glu Lys Pro Ile Val Leu Lys Val Asp Ser Arg Asp 
                 485                490                495
Gly Thr Leu Ser Gly Glu 
             500



<210> 3048
<211> 2015
<212> DNA
<213> Rattus norvegicus
<308> L24207
<400> 3048

gcagagcat  agaggccca  ctagaggga  aacacagag  agtaatttg  tgacagacc  60
gcagggatg  acctgcttt  agctctcac  ctggaaacc  gggtcctcc  ggcagtcgt  120
ctggtgctc  tctacggat  tgggacccg  acacatgga  ttttcaaga  acaggggat  180
cctgggccc  aacctctgc  tttttttgg  actgtgctg  attactata  gggtttatg  240
aaattcgat  tggagtgcc  taaaaagta  ggaaaaata  gggggttgt  tgatggtca  300
atgcctctg  ttgccatca  ggacacaga  atgatcaag  atgtgctag  gaaggaatg  360
ttttctgtc  tcacaaacc  gcgggattt  ggcccagtg  ggattatgg  gaaagccat  420
tctgtatct  aggatgagg  gtggaagag  tatagagcc  tactgtcac  cacgttcac  480
agtggaaga  tcaaggaga  gttccctgt  atcgaacag  atggagaca  tttggtaaa  540
tacttgagg  aagagaaag  caaacctgt  cctgtgaaa  aagtgtttg  tgcctacag  600
atggatgtg  tcaccagca  atcatttgg  gtgaatgtt  attccctca  caacccgaa  660
gatcctttt  tggagaaag  caagaagct  ttaagaatt  atttttttg  tccgttgtt  720
ttgtcagta  tactctttc  attcctcac  ccagtatat  agatgttaa  catctgcat  780
ttcccaaaa  attcaatag  atttttcaa  aaatttgtg  acagaatga  ggaaacccg  840
ctggattct  tgcagaagc  tcgagtgga  tttcttcag  tgatgatga  tgctcataa  900
gattctaaa  acaaagaat  tcatacagc  ctatccgat  tggagatca  agcccagtc  960
atcattttt  tttttgctg  atatgaacc  accagcagc  cactttcct  tgtcctgca  1020
tccctggcc  ctcacccag  tacacagaa  aaactgcag  aggagatcg  cagggctct  1080
cccaataag  cacctccca  ctatgatac  gtgatggaa  tggaatacc  ggatatggt  1140
ttgaatgaa  ccctcagat  gtatccaat  ggtaataga  ttgagagag  ctgtaaaaa  1200
gatgttgaa  tcaatggtg  gtttatgcc  aaagggtca  tggtcatga  tccatctta  1260
gctcttcac  gtgatccac  gcactggcc  gagcctgag  aatttcgcc  agaaaggtt  1320
agcaaggag  acaagggca  cattgatcc  tatgtatat  tgccctttg  aaatggacc  1380
aggaactgc  ttggcatga  gtttgctct  atgaatatg  aactcgctc  cactaaagt  1440
ctgcaaaac  tctccttcc  gccttgtaa  gaaacacag  tacctctga  attaagcag  1500
caaggactt  ttcaaccaa  aaaacccat  attctaaag  ttgtgccac  ggatgaaat  1560
ataactgga  catgatttt  cctcaagga  ttctgctga  ttcgtcaga  atgtggtgt  1620
taagaacac  agacccttt  atttatgtc  tgaataaaa  tcagatgaa  ttagggctt  1680
atcgacttt  ttttgattc  gtacatctt  gatctttct  agtgtctac  atgtaccca  1740
ctaatataa  ggaaatgac  agtcagtga  agaacagga  ttaaccttt  gtgattctc  1800
tgggactac  tccatttgt  tctggttgt  tctgttaat  tcttttgat  gtaaccttg  1860
ctctgtaat  tgatcaaga  ttttcatga  aatgtgaac  attgtgaca  ctttaattg  1920
agatttggt  tcagatgtt  tagatgcat  attctacac  aaatgttac  tggaaaaaa  1980
gtgaataaa  acttcttta  aaatcccca  gggca  2015



<210> 3049
<211> 504
<212> PRT
<213> Rattus norvegicus
<308> P04800
<400> 3049

Met Asp Leu Leu Ser Ala Leu Thr Leu Glu Thr Trp Val Leu Leu Ala 
  1               5                  10                  15
Val Val Leu Val Leu Leu Tyr Gly Phe Gly Thr Arg Thr His Gly Leu 
             20                  25                  30
Phe Lys Lys Gln Gly Ile Pro Gly Pro Lys Pro Leu Pro Phe Phe Gly 
         35                  40                  45
Thr Val Leu Asn Tyr Tyr Met Gly Leu Trp Lys Phe Asp Val Glu Cys 
     50                  55                  60
His Lys Lys Tyr Gly Lys Ile Trp Gly Leu Phe Asp Gly Gln Met Pro 
 65                  70                  75                  80
Leu Phe Ala Ile Thr Asp Thr Glu Met Ile Lys Asn Val Leu Val Lys 
                 85                  90                  95
Glu Cys Phe Ser Val Phe Thr Asn Arg Arg Asp Phe Gly Pro Val Gly 
             100                105                110
Ile Met Gly Lys Ala Val Ser Val Ala Lys Asp Glu Glu Trp Lys Arg 
         115                120                125
Tyr Arg Ala Leu Leu Ser Pro Thr Phe Thr Ser Gly Arg Leu Lys Glu 
     130                135                140
Met Phe Pro Ile Ile Glu Gln Tyr Gly Asp Ile Leu Val Lys Tyr Leu 
 145                150                155                160
Lys Gln Glu Ala Glu Thr Gly Lys Pro Val Thr Met Lys Lys Val Phe 
                 165                170                175
Gly Ala Tyr Ser Met Asp Val Ile Thr Ser Thr Ser Phe Gly Val Asn 
             180                185                190
Val Asp Ser Leu Asn Asn Pro Lys Asp Pro Phe Val Glu Lys Thr Lys 
         195                200                205
Lys Leu Leu Arg Phe Asp Phe Phe Asp Pro Leu Phe Leu Ser Val Val 
     210                215                220
Leu Phe Pro Phe Leu Thr Pro Ile Tyr Glu Met Leu Asn Ile Cys Met 
 225                230                235                240
Phe Pro Lys Asp Ser Ile Glu Phe Phe Lys Lys Phe Val Tyr Arg Met 
                 245                250                255
Lys Glu Thr Arg Leu Asp Ser Val Gln Lys His Arg Val Asp Phe Leu 
             260                265                270
Gln Leu Met Met Asn Ala His Asn Asp Ser Lys Asp Lys Glu Ser His 
         275                280                285
Thr Ala Leu Ser Asp Met Glu Ile Thr Ala Gln Ser Ile Ile Phe Ile 
     290                295                300
Phe Ala Gly Tyr Glu Pro Thr Ser Ser Thr Leu Ser Phe Val Leu His 
 305                310                315                320
Ser Leu Ala Thr His Pro Asp Thr Gln Lys Lys Leu Gln Glu Glu Ile 
                 325                330                335
Asp Arg Ala Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Thr Val Met 
             340                345                350
Glu Met Glu Tyr Leu Asp Met Val Leu Asn Glu Thr Leu Arg Leu Tyr 
         355                360                365
Pro Ile Gly Asn Arg Leu Glu Arg Val Cys Lys Lys Asp Val Glu Ile 
     370                375                380
Asn Gly Val Phe Met Pro Lys Gly Ser Val Val Met Ile Pro Ser Tyr 
 385                390                395                400
Ala Leu His Arg Asp Pro Gln His Trp Pro Glu Pro Glu Glu Phe Arg 
                 405                410                415
Pro Glu Arg Phe Ser Lys Glu Asn Lys Gly Ser Ile Asp Pro Tyr Val 
             420                425                430
Tyr Leu Pro Phe Gly Asn Gly Pro Arg Asn Cys Ile Gly Met Arg Phe 
         435                440                445
Ala Leu Met Asn Met Lys Leu Ala Leu Thr Lys Val Leu Gln Asn Phe 
     450                455                460
Ser Phe Gln Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Ser Arg 
 465                470                475                480
Gln Gly Leu Leu Gln Pro Thr Lys Pro Ile Ile Leu Lys Val Val Pro 
                 485                490                495
Arg Asp Glu Ile Ile Thr Gly Ser 
             500



<210> 3050
<211> 1707
<212> DNA
<213> Homo sapiens
<308> J04813
<400> 3050

gggaagctc  aggcaaaca  cccagcaaa  agcagcact  agctaaaag  aagactcac  60
gaacacagt  gaagaagga  agtggcgat  gacctcatc  caaatttgg  ggtggaaac  120
tggcttctc  tggctgtca  cctggtgct  ctctatcta  atgggaccc  tacacatgg  180
ctttttaag  gactgggaa  tccagggcc  acacctctg  ctttgttgg  aaatgtttt  240
tcctatcgt  agggtctct  gaaatttga  acagagtgc  ataaaaagt  tggaaaaat  300
tggggaacg  atgaaggtc  actccctgt  ctggccatc  cagatcccg  cgtgatcag  360
acagtgcta  tgaaagaat  ttattctgt  ttcacaaat  gaaggtctt  aggcccagt  420
ggatttatg  aaagtgcca  ctctttagc  gaggatgaa  aatggaaga  aatacggtc  480
ttgctgtct  caaccttca  cagcggaaa  ctcaaggag  tgttcccca  cattgccca  540
tatggagat  tattggtga  aaacttgag  cgggaagca  agaaaggca  gcctgtcac  600
ttgaaagac  tctttgggg  ctacagcat  gatgtgatt  ctggcacat  atttggagt  660
aacatcgac  ctctcaaca  tccacaaga  ccctttgtg  agagcacta  gaagttcct  720
aaatttggt  tcttagatc  attatttct  tcaataata  tctttccat  ccttacccc  780
gtttttgaa  cattaaatg  ctctctgtt  ccaaaagat  ccataaatt  tttaagtaa  840
tctgtaaac  gaatgaaga  aagtcgcct  aacgacaaa  aaaagcacc  actagattt  900
cttcagctg  tgattgact  ccagaattc  aaagaaact  agtcccaca  agctctgtc  960
gatctggag  tcgcagccc  gtcaataat  ttcattttt  ctggctatg  aaccaccag  1020
agtgttctt  ccttcactt  atatgaact  gccactcac  ctgatgtcc  gcagaaact  1080
caaaaggag  ttgatgcag  tttgcccaa  aaggcacca  ctacctatg  tgccgtggt  1140
cagatggag  accttgaca  ggtggtgaa  gaaacactc  gattattcc  agttgctat  1200
agacttgag  ggacttgca  gaaagatgt  gaaatcaat  gggtattca  tcccaaagg  1260
tcaatggtg  tgattccaa  ttatgctct  caccatgac  caaagtact  gacagagcc  1320
gaggagttc  gccctgaaa  gttcagtaa  aagaaggac  gcatagatc  ttacatata  1380
acacccttt  gaactggac  cagaaactg  attggcatg  ggtttgctc  catgaacat  1440
aaacttgct  taatcagag  ccttcagaa  ttctccttc  aaccttgta  agaaacaca  1500
atccccttg  aattagaca  gcaaggact  cttcaacca  aaaaaccca  tgttctaaa  1560
gtggattca  gagatggaa  cctaagtgg  gaatgagtt  ttctaagga  ttctacttt  1620
gtcttcaag  aagctgtgc  ccagaacac  agagatttc  acttagtca  taaaacctt  1680
aaataaaga  gggcttaat  taatgta  1707



<210> 3051
<211> 502
<212> PRT
<213> Homo sapiens
<308> P20815
<400> 3051

Met Asp Leu Ile Pro Asn Leu Ala Val Glu Thr Trp Leu Leu Leu Ala 
  1               5                  10                  15
Val Ser Leu Val Leu Leu Tyr Leu Tyr Gly Thr Arg Thr His Gly Leu 
             20                  25                  30
Phe Lys Arg Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly 
         35                  40                  45
Asn Val Leu Ser Tyr Arg Gln Gly Leu Trp Lys Phe Asp Thr Glu Cys 
     50                  55                  60
Tyr Lys Lys Tyr Gly Lys Met Trp Gly Thr Tyr Glu Gly Gln Leu Pro 
 65                  70                  75                  80
Val Leu Ala Ile Thr Asp Pro Asp Val Ile Arg Thr Val Leu Val Lys 
                 85                  90                  95
Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Ser Leu Gly Pro Val Gly 
             100                105                110
Phe Met Lys Ser Ala Ile Ser Leu Ala Glu Asp Glu Glu Trp Lys Arg 
         115                120                125
Ile Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
     130                135                140
Met Phe Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
 145                150                155                160
Arg Arg Glu Ala Glu Lys Gly Lys Pro Val Thr Leu Lys Asp Ile Phe 
                 165                170                175
Gly Ala Tyr Ser Met Asp Val Ile Thr Gly Thr Ser Phe Gly Val Asn 
             180                185                190
Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Ser Thr Lys 
         195                200                205
Lys Phe Leu Lys Phe Gly Phe Leu Asp Pro Leu Phe Leu Ser Ile Ile 
     210                215                220
Leu Phe Pro Phe Leu Thr Pro Val Phe Glu Ala Leu Asn Val Ser Leu 
 225                230                235                240
Phe Pro Lys Asp Thr Ile Asn Phe Leu Ser Lys Ser Val Asn Arg Met 
                 245                250                255
Lys Lys Ser Arg Leu Asn Asp Lys Gln Lys His Arg Leu Asp Phe Leu 
             260                265                270
Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Glu Ser His Lys 
         275                280                285
Ala Leu Ser Asp Leu Glu Leu Ala Ala Gln Ser Ile Ile Phe Ile Phe 
     290                295                300
Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Thr Leu Tyr Glu 
 305                310                315                320
Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Lys Glu Ile Asp 
                 325                330                335
Ala Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Ala Val Val Gln 
             340                345                350
Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
         355                360                365
Val Ala Ile Arg Leu Glu Arg Thr Cys Lys Lys Asp Val Glu Ile Asn 
     370                375                380
Gly Val Phe Ile Pro Lys Gly Ser Met Val Val Ile Pro Thr Tyr Ala 
 385                390                395                400
Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Glu Phe Arg Pro 
                 405                410                415
Glu Arg Phe Ser Lys Lys Lys Asp Ser Ile Asp Pro Tyr Ile Tyr Thr 
             420                425                430
Pro Phe Gly Thr Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala Leu 
         435                440                445
Met Asn Met Lys Leu Ala Leu Ile Arg Val Leu Gln Asn Phe Ser Phe 
     450                455                460
Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Asp Thr Gln Gly 
 465                470                475                480
Leu Leu Gln Pro Glu Lys Pro Ile Val Leu Lys Val Asp Ser Arg Asp 
                 485                490                495
Gly Thr Leu Ser Gly Glu 
             500



<210> 3052
<211> 1101
<212> DNA
<213> Rattus norvegicus
<308> L24776
<400> 3052

agcagctgg  taggcacca  ggccgggag  accaccatc  aggcggtaa  gcgcaagat  60
caggttctg  agcagcagg  tgatgatgc  gaggagagg  ctgagcgcc  ccagcggga  120
gtggaggga  aaaggcggg  ccgggagca  gctgaagct  aggtggctt  cttgaaccg  180
aggatccag  tggttgaag  ggagctgga  cgcgcccag  agcgccttg  cactgcttt  240
cagaagctg  aggaagcgg  gaaggctgc  gatgagagt  agagaggta  gaaggtgat  300
gaaaaccgg  ctctaaaag  tgaagaaaa  atggagctc  aggaaatcc  gctgaagga  360
gcaaagcac  ttgcagaag  ggcagacag  aagtatgaa  aggtggctc  taagttggt  420
atcattgaa  gagacttgg  acgcacgga  gaacgcgcc  agctggcag  gtctaagtg  480
tctgagctg  aggaggagc  gaagaatgt  accaacaac  tcaaatctc  tgaggctca  540
gcggagaag  actctcaaa  agaagacaa  tatgaagaa  aaataaaga  tcttactga  600
aaactcaag  aggcggaga  ccgggctga  tttgctgaa  gatcggtag  caagctgga  660
aagaccatt  atgacttgg  agatgagct  tatgcccag  aactgaagt  caaggccat  720
agcgacgag  tggaccacg  cctcaatga  atgacctct  tataaactg  caccgtttc  780
gctctgtcc  ggatctacc  ccctttcag  ggtaattga  atgatataa  gggcctagg  840
atacaattg  tgttagggc  tttattaga  taatgttgg  gtactcggc  atgaagaat  900
gggcgaatg  tcctgcggc  tattcgacg  taaagcctg  gactaattc  gattctcct  960
ctgttaagt  gaagggagc  cgatttgtt  ctgctaggg  tgaaatgta  catattatg  1020
ctattggtc  ggcggggat  aatagtcag  tatgttctt  tgcacttat  agtatttct  1080
gggagaagg  gccgcttat  a  1101



<210> 3053
<211> 350
<212> PRT
<213> Rattus norvegicus
<308> OKRTCB
<400> 3053

Gly Asn Thr Ala Ile Ala Lys Lys Gly Ser Glu Val Glu Ser Val Lys 
  1               5                  10                  15
Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Arg Lys Trp Glu Asn 
             20                  25                  30
Pro Pro Pro Ser Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys Thr 
         35                  40                  45
Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys Ala 
     50                  55                  60
Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val Val 
 65                  70                  75                  80
Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu Gln 
                 85                  90                  95
Ala Val Glu Phe Pro Phe Leu Val Arg Leu Glu Tyr Ser Phe Lys Asp 
             100                105                110
Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu Met 
         115                120                125
Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala Arg 
     130                135                140
Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser Leu 
 145                150                155                160
Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp His 
                 165                170                175
Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val Lys 
             180                185                190
Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
         195                200                205
Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala Leu 
     210                215                220
Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe Ala 
 225                230                235                240
Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val Arg 
                 245                250                255
Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn Leu 
             260                265                270
Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly Val 
         275                280                285
Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp Trp Ile Ala 
     290                295                300
Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Arg Gly 
 305                310                315                320
Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Glu Ile Arg 
                 325                330                335
Val Ser Ile Thr Glu Lys Cys Gly Lys Glu Phe Cys Glu Phe 
             340                345                350



<210> 3054
<211> 2945
<212> DNA
<213> Homo sapiens
<308> M34181
<400> 3054

ccagccccc  ttcccttcc  tgacccctt  ttgccatcg  cccagacat  gggaacgcg  60
cgaccgcca  gaaaggcag  gaggtggag  gcgtgaaag  gtttctagc  aaagccaaa  120
aagactttt  gaaaaaatg  gagaatcca  ctcagaata  tgccggact  gaagatttt  180
aaaggaaaa  aacccttgg  acaggttca  ttggaagag  catgttggt  aaacacaaa  240
ccactgaac  gtattatgc  atgaagatc  tagataagc  gaaggttgt  aaactgaag  300
aaatagagc  tactttgaa  gagaaaaga  tattacagg  agtgaattt  cctttcctt  360
ttcgactgg  gtatgcttt  aaggataat  ctaatttat  catggttat  gaatatgtc  420
ctgggggtg  aatgttttc  catctaaga  gaattggaa  gttcagtga  ccccatgca  480
ggttctatg  agctcagat  gtgctaaca  tcgagtacc  ccattcact  gacctcatc  540
acagagatc  aaaacctga  aatctctta  ttgaccatc  aggctatat  caggtcaca  600
actttgggt  tgccaaaag  gttaaaggc  gaacttgga  attatgtgg  actccagag  660
atttggctc  agaaataat  ctcagcaag  gctacaata  ggcagtgga  tggtgggca  720
taggagtgc  aatctatga  atggcagct  gctatcccc  attctttgc  gaccaacca  780
ttcagattt  tgaaaagat  gtttctgga  aggtccgat  cccatccca  ttcagttca  840
atctcaagg  ccttctacg  aacctgctg  aggtggatt  gaccaagag  tttggaaat  900
taaagaatg  tgtcagtga  ataaaaact  acaagtggt  tgccacgac  gattggatt  960
ctatttacc  gaggaaggt  gaagctcca  tcataccaa  gtttagagg  tctggagat  1020
ccagcaact  tgatgacta  gaagaagaa  atatccgtg  ctctataac  gaaaaatgt  1080
caaaagaat  tggtgaatt  taaagagga  caagatgac  tctgagctc  cactcagtg  1140
ttgcactct  ttgagagat  aggtagagc  gagaccgtc  ttgttgaag  agttaccta  1200
ttccttcat  ccaacgact  agtgaggtc  ttattgcca  catccgtgt  cgcactctg  1260
atccaccta  gtaacaagg  accgctaag  aagcattgt  tgtgccata  cacagtact  1320
gaccacttt  ttacttctc  ttgggttgt  tttctcctc  cctacatcc  tttcttcct  1380
ttcaatttc  ttggttttc  ctaaacagt  ctccatttt  ttttgttgg  gtttcagat  1440
ggcagtgtt  tggctacgt  atatttgaa  ggaaggata  gtgttgctt  cagtagtta  1500
tgccaatat  gttgttggt  aatggcttg  agataaact  tctaataat  attatttct  1560
tgagtagct  agacttggt  ttgccaaaa  tcttggtaa  ttttgaaga  agactgtct  1620
atcaccaag  aaatttata  aaattaaga  taactttct  ggaattcac  attctggca  1680
taaattttg  tagactaat  cagtacagc  agacccaga  atttggaag  ctgtagatc  1740
gaggttcta  ttccctttc  ctcctttta  atcctcctc  ccttgagta  tgaagtgac  1800
agcctgtgt  gtgtgacaa  cgtgtctca  tcagcagga  aaactaatg  tatggatca  1860
cacccagat  ctctcactt  gtaccagca  ttctgtagg  attagagaa  agttctaag  1920
tttctaaac  ttaactgtt  cttaaggat  ttagccagt  ttttaatag  acatgatta  1980
tgaaagtga  aaattttaa  ttttctcta  tagtcctca  cataaactt  ttaaaggaa  2040
ataagcaaa  taaaaagaa  attggttta  ataaatact  atactttgc  aagtcaaaa  2100
tggcttgat  tttggaaac  atatagagg  attcatatt  aaatgaggg  ttacatttg  2160
tttgttttg  aaccgttaa  aagaagttg  ttccagcta  ttattgtgg  gtactatat  2220
tgtgagcct  gggtagggg  actgctgca  cttctgctt  catcccatg  ctcatcaat  2280
aggaaaggg  acaaagtgt  taaaacctg  cacaattgt  ttttaattt  gaggtatga  2340
attttcaga  atttcataa  ttctaacct  tgttctctc  gtaaacaga  tgtctgatc  2400
atcatgcag  tacaatgtt  gtatttgag  ggttagttt  tttcctaca  ttttttttg  2460
caactgact  aacaacatt  ctgtcaggt  gaaatttca  gcacttttg  acatttagt  2520
cagtgtttg  tgagaatcc  tggcttaac  cacttgttt  gctattttt  tctttgctt  2580
taattttcc  catctgatt  tatctctgc  tttcagtga  ctaccttaa  acaacacac  2640
agaagagtt  aactgggtt  attttaatg  tcaatttac  tgcatataa  atttatttt  2700
aatcaagct  atcttaatg  atataatca  tctatttgc  ttattatcg  tgcaggtag  2760
tcattaaca  cacttcttt  catctgtac  acaccctgg  gaaaccttt  aagacataa  2820
aaaaacctg  ctgagatgt  ctttctacc  atctatatg  ctttcggtt  tcaagtgtt  2880
ctgcatggt  atgtcatgt  aatgctgat  ttgatttca  tggtccatc  atatttaaa  2940
cgtgc  2945



<210> 3055
<211> 350
<212> PRT
<213> Homo sapiens
<308> P22694
<400> 3055

Gly Asn Ala Ala Thr Ala Lys Lys Gly Ser Glu Val Glu Ser Val Lys 
  1               5                  10                  15
Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu Asn 
             20                  25                  30
Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys Thr 
         35                  40                  45
Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys Ala 
     50                  55                  60
Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val Val 
 65                  70                  75                  80
Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu Gln 
                 85                  90                  95
Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr Ala Phe Lys Asp 
             100                105                110
Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu Met 
         115                120                125
Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala Arg 
     130                135                140
Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser Leu 
 145                150                155                160
Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp His 
                 165                170                175
Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val Lys 
             180                185                190
Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
         195                200                205
Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala Leu 
     210                215                220
Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe Ala 
 225                230                235                240
Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val Arg 
                 245                250                255
Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn Leu 
             260                265                270
Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly Val 
         275                280                285
Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp Trp Ile Ala 
     290                295                300
Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Arg Gly 
 305                310                315                320
Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Asp Ile Arg 
                 325                330                335
Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly Glu Phe 
             340                345                350



<210> 3056
<211> 1101
<212> DNA
<213> Rattus norvegicus
<308> L24776
<400> 3056

agcagctgg  taggcacca  ggccgggag  accaccatc  aggcggtaa  gcgcaagat  60
caggttctg  agcagcagg  tgatgatgc  gaggagagg  ctgagcgcc  ccagcggga  120
gtggaggga  aaaggcggg  ccgggagca  gctgaagct  aggtggctt  cttgaaccg  180
aggatccag  tggttgaag  ggagctgga  cgcgcccag  agcgccttg  cactgcttt  240
cagaagctg  aggaagcgg  gaaggctgc  gatgagagt  agagaggta  gaaggtgat  300
gaaaaccgg  ctctaaaag  tgaagaaaa  atggagctc  aggaaatcc  gctgaagga  360
gcaaagcac  ttgcagaag  ggcagacag  aagtatgaa  aggtggctc  taagttggt  420
atcattgaa  gagacttgg  acgcacgga  gaacgcgcc  agctggcag  gtctaagtg  480
tctgagctg  aggaggagc  gaagaatgt  accaacaac  tcaaatctc  tgaggctca  540
gcggagaag  actctcaaa  agaagacaa  tatgaagaa  aaataaaga  tcttactga  600
aaactcaag  aggcggaga  ccgggctga  tttgctgaa  gatcggtag  caagctgga  660
aagaccatt  atgacttgg  agatgagct  tatgcccag  aactgaagt  caaggccat  720
agcgacgag  tggaccacg  cctcaatga  atgacctct  tataaactg  caccgtttc  780
gctctgtcc  ggatctacc  ccctttcag  ggtaattga  atgatataa  gggcctagg  840
atacaattg  tgttagggc  tttattaga  taatgttgg  gtactcggc  atgaagaat  900
gggcgaatg  tcctgcggc  tattcgacg  taaagcctg  gactaattc  gattctcct  960
ctgttaagt  gaagggagc  cgatttgtt  ctgctaggg  tgaaatgta  catattatg  1020
ctattggtc  ggcggggat  aatagtcag  tatgttctt  tgcacttat  agtatttct  1080
gggagaagg  gccgcttat  a  1101



<210> 3057
<211> 350
<212> PRT
<213> Rattus norvegicus
<308> OKRTCB
<400> 3057

Gly Asn Thr Ala Ile Ala Lys Lys Gly Ser Glu Val Glu Ser Val Lys 
  1               5                  10                  15
Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Arg Lys Trp Glu Asn 
             20                  25                  30
Pro Pro Pro Ser Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys Thr 
         35                  40                  45
Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys Ala 
     50                  55                  60
Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val Val 
 65                  70                  75                  80
Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu Gln 
                 85                  90                  95
Ala Val Glu Phe Pro Phe Leu Val Arg Leu Glu Tyr Ser Phe Lys Asp 
             100                105                110
Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu Met 
         115                120                125
Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala Arg 
     130                135                140
Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser Leu 
 145                150                155                160
Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp His 
                 165                170                175
Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val Lys 
             180                185                190
Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
         195                200                205
Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala Leu 
     210                215                220
Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe Ala 
 225                230                235                240
Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val Arg 
                 245                250                255
Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn Leu 
             260                265                270
Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly Val 
         275                280                285
Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp Trp Ile Ala 
     290                295                300
Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Arg Gly 
 305                310                315                320
Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Glu Ile Arg 
                 325                330                335
Val Ser Ile Thr Glu Lys Cys Gly Lys Glu Phe Cys Glu Phe 
             340                345                350



<210> 3058
<211> 2945
<212> DNA
<213> Homo sapiens
<308> M34181
<400> 3058

ccagccccc  ttcccttcc  tgacccctt  ttgccatcg  cccagacat  gggaacgcg  60
cgaccgcca  gaaaggcag  gaggtggag  gcgtgaaag  gtttctagc  aaagccaaa  120
aagactttt  gaaaaaatg  gagaatcca  ctcagaata  tgccggact  gaagatttt  180
aaaggaaaa  aacccttgg  acaggttca  ttggaagag  catgttggt  aaacacaaa  240
ccactgaac  gtattatgc  atgaagatc  tagataagc  gaaggttgt  aaactgaag  300
aaatagagc  tactttgaa  gagaaaaga  tattacagg  agtgaattt  cctttcctt  360
ttcgactgg  gtatgcttt  aaggataat  ctaatttat  catggttat  gaatatgtc  420
ctgggggtg  aatgttttc  catctaaga  gaattggaa  gttcagtga  ccccatgca  480
ggttctatg  agctcagat  gtgctaaca  tcgagtacc  ccattcact  gacctcatc  540
acagagatc  aaaacctga  aatctctta  ttgaccatc  aggctatat  caggtcaca  600
actttgggt  tgccaaaag  gttaaaggc  gaacttgga  attatgtgg  actccagag  660
atttggctc  agaaataat  ctcagcaag  gctacaata  ggcagtgga  tggtgggca  720
taggagtgc  aatctatga  atggcagct  gctatcccc  attctttgc  gaccaacca  780
ttcagattt  tgaaaagat  gtttctgga  aggtccgat  cccatccca  ttcagttca  840
atctcaagg  ccttctacg  aacctgctg  aggtggatt  gaccaagag  tttggaaat  900
taaagaatg  tgtcagtga  ataaaaact  acaagtggt  tgccacgac  gattggatt  960
ctatttacc  gaggaaggt  gaagctcca  tcataccaa  gtttagagg  tctggagat  1020
ccagcaact  tgatgacta  gaagaagaa  atatccgtg  ctctataac  gaaaaatgt  1080
caaaagaat  tggtgaatt  taaagagga  caagatgac  tctgagctc  cactcagtg  1140
ttgcactct  ttgagagat  aggtagagc  gagaccgtc  ttgttgaag  agttaccta  1200
ttccttcat  ccaacgact  agtgaggtc  ttattgcca  catccgtgt  cgcactctg  1260
atccaccta  gtaacaagg  accgctaag  aagcattgt  tgtgccata  cacagtact  1320
gaccacttt  ttacttctc  ttgggttgt  tttctcctc  cctacatcc  tttcttcct  1380
ttcaatttc  ttggttttc  ctaaacagt  ctccatttt  ttttgttgg  gtttcagat  1440
ggcagtgtt  tggctacgt  atatttgaa  ggaaggata  gtgttgctt  cagtagtta  1500
tgccaatat  gttgttggt  aatggcttg  agataaact  tctaataat  attatttct  1560
tgagtagct  agacttggt  ttgccaaaa  tcttggtaa  ttttgaaga  agactgtct  1620
atcaccaag  aaatttata  aaattaaga  taactttct  ggaattcac  attctggca  1680
taaattttg  tagactaat  cagtacagc  agacccaga  atttggaag  ctgtagatc  1740
gaggttcta  ttccctttc  ctcctttta  atcctcctc  ccttgagta  tgaagtgac  1800
agcctgtgt  gtgtgacaa  cgtgtctca  tcagcagga  aaactaatg  tatggatca  1860
cacccagat  ctctcactt  gtaccagca  ttctgtagg  attagagaa  agttctaag  1920
tttctaaac  ttaactgtt  cttaaggat  ttagccagt  ttttaatag  acatgatta  1980
tgaaagtga  aaattttaa  ttttctcta  tagtcctca  cataaactt  ttaaaggaa  2040
ataagcaaa  taaaaagaa  attggttta  ataaatact  atactttgc  aagtcaaaa  2100
tggcttgat  tttggaaac  atatagagg  attcatatt  aaatgaggg  ttacatttg  2160
tttgttttg  aaccgttaa  aagaagttg  ttccagcta  ttattgtgg  gtactatat  2220
tgtgagcct  gggtagggg  actgctgca  cttctgctt  catcccatg  ctcatcaat  2280
aggaaaggg  acaaagtgt  taaaacctg  cacaattgt  ttttaattt  gaggtatga  2340
attttcaga  atttcataa  ttctaacct  tgttctctc  gtaaacaga  tgtctgatc  2400
atcatgcag  tacaatgtt  gtatttgag  ggttagttt  tttcctaca  ttttttttg  2460
caactgact  aacaacatt  ctgtcaggt  gaaatttca  gcacttttg  acatttagt  2520
cagtgtttg  tgagaatcc  tggcttaac  cacttgttt  gctattttt  tctttgctt  2580
taattttcc  catctgatt  tatctctgc  tttcagtga  ctaccttaa  acaacacac  2640
agaagagtt  aactgggtt  attttaatg  tcaatttac  tgcatataa  atttatttt  2700
aatcaagct  atcttaatg  atataatca  tctatttgc  ttattatcg  tgcaggtag  2760
tcattaaca  cacttcttt  catctgtac  acaccctgg  gaaaccttt  aagacataa  2820
aaaaacctg  ctgagatgt  ctttctacc  atctatatg  ctttcggtt  tcaagtgtt  2880
ctgcatggt  atgtcatgt  aatgctgat  ttgatttca  tggtccatc  atatttaaa  2940
cgtgc  2945



<210> 3059
<211> 350
<212> PRT
<213> Homo sapiens
<308> P22694
<400> 3059

Gly Asn Ala Ala Thr Ala Lys Lys Gly Ser Glu Val Glu Ser Val Lys 
  1               5                  10                  15
Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu Asn 
             20                  25                  30
Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys Thr 
         35                  40                  45
Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys Ala 
     50                  55                  60
Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val Val 
 65                  70                  75                  80
Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu Gln 
                 85                  90                  95
Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr Ala Phe Lys Asp 
             100                105                110
Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu Met 
         115                120                125
Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala Arg 
     130                135                140
Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser Leu 
 145                150                155                160
Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp His 
                 165                170                175
Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val Lys 
             180                185                190
Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
         195                200                205
Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala Leu 
     210                215                220
Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe Ala 
 225                230                235                240
Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val Arg 
                 245                250                255
Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn Leu 
             260                265                270
Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly Val 
         275                280                285
Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp Trp Ile Ala 
     290                295                300
Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Arg Gly 
 305                310                315                320
Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Asp Ile Arg 
                 325                330                335
Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly Glu Phe 
             340                345                350



<210> 3060
<211> 2987
<212> DNA
<213> Rattus norvegicus
<308> L25331
<400> 3060

gttgcccaa  gaaataaat  cattgggaa  tcagtgtgc  ggtccatgc  accaagaga  60
cattacttc  ggtgatcgt  ttctcccaa  ctccacagt  tagctttgt  tcagtgccg  120
cggatcgtc  ccaagactc  actatgcgg  ccctgctgc  cctggcctc  ctggcctgg  180
ttcttctgg  ccaggcgaa  gacgacgcc  agctggagg  caacctttt  gtcctcacc  240
tggccacaa  agagacaga  ggcttccgc  gattcaagc  ctcagccca  ttcttcaac  300
acaagatcc  gtcactggg  ctgggggag  actggagcg  ggccggggg  ccatcggca  360
caggtggag  acagaaggt  cggctgctg  agaaggcac  gaaaaagta  gcagacaag  420
aagacttgg  tattctctt  gttgacagc  atgacgtgg  gtttgcctc  ggaccccgg  480
aactcttaa  gaagttcca  caggccaag  gccgggtgg  cttctcagc  gaggagctt  540
tctaccctg  ccggaggct  gaggccaag  atcccacag  ccccgatgg  aaacgattc  600
tgggctctg  aggcttcat  ggttatgct  ccagcctca  caaactggt  gccgagtgg  660
agggccagg  caatgacag  gaccagctc  tttatacca  gatcttctt  gacccggag  720
agagggagc  aatcaatat  agcctggac  atcgctgcc  aatcttcca  aacctggat  780
gagccttgg  tgaagttgt  ctcaagttt  aaatgggcc  cgtgagagc  cggaatctg  840
cctatgaca  cctcccagt  gtcatccac  gcaacgggc  caccaagct  caggtgaac  900
acctgggca  ctacattcc  cgattctgg  ccttcgaaa  gggctgcac  gtgtgcgac  960
agggcctgc  aagcctcaa  ggcattggg  atgaagctc  ccctaccgt  ctggtcggt  1020
tgttcattg  gcagcccac  ccattccta  ccttgttct  tcggcggct  ctgcaccta  1080
gataccctc  gaaacagat  cggctcttc  ttcacaacc  agaacagca  cacaagctt  1140
aggtagagc  gttcctggc  gagcacggc  gtgagtacc  gtctgtgaa  ctagtgggt  1200
ccgaggtac  catggccaa  gcagacgcc  ggaacatgg  cgccgacct  tgccgccag  1260
atcaaacat  cacctacta  ttcagtgtg  atgctgacg  ggccctgac  gagccgaac  1320
gcctacggc  cctgattga  caaaacaag  atgtcattg  tccactcat  acccgtcac  1380
ggaggctct  gtccaactt  tggggggca  tgagtgcgg  tgggtacta  gcccgctcg  1440
aggactacg  ggacatcgt  cagggccgt  gtgttggcg  ctggaatgt  ccttacatc  1500
caaacatct  cctgatcaa  ggcagtgcc  tgcgggccg  gctgcggca  gtagacctg  1560
tccactaca  caagctgga  cctgacatg  gtttctgcg  caatgtccg  cagcaggag  1620
tgttcatgt  cctgaccaa  cggcatacc  ttggccacc  gctgtcgct  gataattac  1680
agaccaccc  cctacataa  gatctctgg  aggtgttca  caaccctca  gattggaaa  1740
agaagtaca  ccacgagaa  tacaccaag  ccctggcag  gaagctggt  gagacgcct  1800
gtccggatg  ctactggtt  cccatcttc  cggaggtgg  ctgtgatga  ctggtggag  1860
aaatggaac  ctacggcca  tggtctctg  gtgacaata  ggacaaccg  atccagggt  1920
gctatgaaa  cgtgcccac  attgacatc  acatgaacc  gatcacctt  gagcgggag  1980
ggcacaagt  cctggtgga  tacatcgcc  ccctgacag  gaagctgta  cccggctac  2040
acaccaagg  ccagtttga  ctagccttc  tcgtccgct  taagcctga  gagcagcct  2100
ccttgatgc  tcaccatga  gcctctact  tcaccatca  catagccct  aacagggtt  2160
gggaagatt  tgagggtgg  ggttgccga  ttctacgct  caactgctc  gtgagagcc  2220
caaggaagg  ctgggccct  atgcacccc  ggcggctca  acactacca  gaggggctt  2280
ccactacca  gggtacccg  tacattgcc  tgtccttcg  cgatcccta  ctgcttgcc  2340
agtgcctgc  tccattcga  ctatctctt  attgacaac  actgcctag  agcctctgg  2400
gccaaggaa  ccaatccga  ctctgattc  tgaattcct  ttgctcttg  agctgccag  2460
tggaaggat  gggtgcagg  cagaaatgg  gcaccccct  caagactgg  gctgcccgt  2520
gtgctccca  cagtctccg  agatggtag  aatgtttat  ttcctggag  tcctaacct  2580
ccttcttct  tgactttcc  tggggccag  cttctgctg  agagttcct  gagagtcag  2640
agctttgcc  agaggactt  tagaagagc  agcccccgg  atcctgttt  aagattcag  2700
gccaccaag  tctgggtca  ccaacttac  ccaacttca  ccctgcctg  actgttgat  2760
cgctctctt  caggttttt  tcaccggag  aaatagttg  ctctattga  actataact  2820
gaaatcctc  cggaggggc  ggaaagaca  ctgtgacaa  gcttggctc  ctgctgacc  2880
tgcttgagg  aggggcaca  gttcacact  tactaggtc  ccctgcccc  atgcctgtg  2940
ggacaggga  agagatgag  gttctatta  attttgttc  aaccaaa  2987



<210> 3061
<211> 728
<212> PRT
<213> Rattus norvegicus
<308> Q63321
<400> 3061

Met Arg Ser Leu Leu Leu Leu Ala Ser Leu Ala Trp Leu Leu Leu Ala 
  1               5                  10                  15
Gln Ala Lys Asp Asp Ala Lys Leu Glu Asp Asn Leu Leu Val Leu Thr 
             20                  25                  30
Val Ala Thr Lys Glu Thr Glu Gly Phe Arg Arg Phe Lys Arg Ser Ala 
         35                  40                  45
Gln Phe Phe Asn Tyr Lys Ile Gln Ser Leu Gly Leu Gly Glu Asp Trp 
     50                  55                  60
Ser Ala Ala Gly Gly Pro Ser Ala Ala Gly Gly Gly Gln Lys Val Arg 
 65                  70                  75                  80
Leu Leu Lys Lys Ala Leu Lys Lys Tyr Ala Asp Lys Glu Asp Leu Val 
                 85                  90                  95
Ile Leu Phe Val Asp Ser Tyr Asp Val Val Phe Ala Ser Gly Pro Arg 
             100                105                110
Glu Leu Leu Lys Lys Phe Gln Gln Ala Lys Ser Arg Val Val Phe Ser 
         115                120                125
Ala Glu Glu Leu Ile Tyr Pro Asp Arg Arg Leu Glu Ala Lys Tyr Pro 
     130                135                140
Thr Val Pro Asp Gly Lys Arg Phe Leu Gly Ser Gly Gly Phe Ile Gly 
 145                150                155                160
Tyr Ala Pro Ser Leu Ser Lys Leu Val Ala Glu Trp Glu Gly Gln Asp 
                 165                170                175
Asn Asp Ser Asp Gln Leu Phe Tyr Thr Lys Ile Phe Leu Asp Pro Glu 
             180                185                190
Lys Arg Glu Gln Ile Asn Ile Ser Leu Asp His Arg Cys Arg Ile Phe 
         195                200                205
Gln Asn Leu Asp Gly Ala Leu Asp Glu Val Val Leu Lys Phe Glu Met 
     210                215                220
Gly His Val Arg Ala Arg Asn Leu Ala Tyr Asp Thr Leu Pro Val Val 
 225                230                235                240
Ile His Gly Asn Gly Pro Thr Lys Leu Gln Val Asn Tyr Leu Gly Asn 
                 245                250                255
Tyr Ile Pro Arg Phe Trp Thr Phe Glu Thr Gly Cys Thr Val Cys Asp 
             260                265                270
Glu Gly Leu Arg Ser Leu Lys Gly Ile Gly Asp Glu Ala Leu Pro Thr 
         275                280                285
Val Leu Val Gly Val Phe Ile Glu Gln Pro Thr Pro Phe Leu Ser Leu 
     290                295                300
Phe Phe Arg Arg Leu Leu His Leu Arg Tyr Pro Gln Lys Gln Met Arg 
 305                310                315                320
Leu Phe Ile His Asn Gln Glu Gln His His Lys Leu Gln Val Glu Gln 
                 325                330                335
Phe Leu Ala Glu His Gly Gly Glu Tyr Gln Ser Val Lys Leu Val Gly 
             340                345                350
Pro Glu Val Arg Met Ala Asn Ala Asp Ala Arg Asn Met Gly Ala Asp 
         355                360                365
Leu Cys Arg Gln Asp Gln Thr Cys Thr Tyr Tyr Phe Ser Val Asp Ala 
     370                375                380
Asp Val Ala Leu Thr Glu Pro Asn Ser Leu Arg Leu Leu Ile Glu Gln 
 385                390                395                400
Asn Lys Asn Val Ile Ala Pro Leu Met Thr Arg His Gly Arg Leu Trp 
                 405                410                415
Ser Asn Phe Trp Gly Ala Leu Ser Ala Asp Gly Tyr Tyr Ala Arg Ser 
             420                425                430
Glu Asp Tyr Val Asp Ile Val Gln Gly Arg Arg Val Gly Val Trp Asn 
         435                440                445
Val Pro Tyr Ile Ser Asn Ile Tyr Leu Ile Lys Gly Ser Ala Leu Arg 
     450                455                460
Ala Glu Leu Arg His Val Asp Leu Phe His Tyr Ser Lys Leu Asp Pro 
 465                470                475                480
Asp Met Ser Phe Cys Ala Asn Val Arg Gln Gln Glu Val Phe Met Phe 
                 485                490                495
Leu Thr Asn Arg His Thr Phe Gly His Leu Leu Ser Leu Asp Asn Tyr 
             500                505                510
Gln Thr Thr His Leu His Asn Asp Leu Trp Glu Val Phe Ser Asn Pro 
         515                520                525
Gln Asp Trp Lys Glu Lys Tyr Ile His Glu Asn Tyr Thr Lys Ala Leu 
     530                535                540
Ala Gly Lys Leu Val Glu Thr Pro Cys Pro Asp Val Tyr Trp Phe Pro 
 545                550                555                560
Ile Phe Thr Glu Val Ala Cys Asp Glu Leu Val Glu Glu Met Glu His 
                 565                570                575
Tyr Gly Gln Trp Ser Leu Gly Asp Asn Lys Asp Asn Arg Ile Gln Gly 
             580                585                590
Gly Tyr Glu Asn Val Pro Thr Ile Asp Ile His Met Asn Gln Ile Thr 
         595                600                605
Phe Glu Arg Glu Trp His Lys Phe Leu Val Glu Tyr Ile Ala Pro Leu 
     610                615                620
Thr Glu Lys Leu Tyr Pro Gly Tyr Tyr Thr Lys Ala Gln Phe Asp Leu 
 625                630                635                640
Ala Phe Val Val Arg Tyr Lys Pro Asp Glu Gln Pro Ser Leu Met Pro 
                 645                650                655
His His Asp Ala Ser Thr Phe Thr Ile Asn Ile Ala Leu Asn Arg Val 
             660                665                670
Gly Glu Asp Tyr Glu Gly Gly Gly Cys Arg Phe Leu Arg Tyr Asn Cys 
         675                680                685
Ser Val Arg Ala Pro Arg Lys Gly Trp Ala Leu Met His Pro Gly Arg 
     690                695                700
Leu Thr His Tyr His Glu Gly Leu Pro Thr Thr Lys Gly Thr Arg Tyr 
 705                710                715                720
Ile Ala Val Ser Phe Val Asp Pro 
                 725



<210> 3062
<211> 3115
<212> DNA
<213> Homo sapiens
<308> NM_000302
<400> 3062

ccaccatat  ggtcccgta  ttcacattg  taaggtcct  tttcatttc  cgtgacatt  60
ggtagaatg  ggatcctgt  ttcaatggg  cgctttacc  tgggactga  agggaggct  120
tgaccattt  gccaccaaa  gtaggtgta  ttctcactc  taggttcac  ccgcggccg  180
tcgtccccc  tacctcggc  atgcggccc  tgctgctac  ggccctgct  ggctggctg  240
tgctggccg  agcgaaggg  gacgccaag  cggaggaca  ccttttagt  ctcacggtg  300
ccactaagg  gaccgaggg  ttccgtcgc  tcaagcgct  agctcagtt  ttcaactac  360
agatccagg  gcttggcct  ggggaggac  ggaatgtgg  gaaggggac  tcggcaggt  420
gagggcaga  ggtccggct  ctgaagaaa  ctctggaga  gcacgcaga  aaggaggat  480
tggtcattc  cttcacaga  agctatgac  tgctgtttg  atcggggcc  cgggagctc  540
tgaagaagt  ccggcaggc  aggagccag  tggtcttct  tgctgagga  ctcatctac  600
cagaccgca  gctggagac  aagtatccg  tggtgtccg  tggcaagag  ttcctgggc  660
ctggaggct  catcggtta  gcccccaac  tcagcaaac  ggtggccga  tgggagggc  720
aggacagcg  cagcgatca  ctgttttac  ccaagatct  cttggaccc  gagaagagg  780
agcagatca  tatcaccct  gaccaccgc  gccgtatct  ccagaacct  gatggagcc  840
tggatgagg  cgtgctcaa  tttgaaatg  gccatgtga  agcgaggaa  ctggcctat  900
acaccctcc  ggtcctgat  catggcaac  ggccaacca  gctgcagtt  aactacctg  960
gcaactaca  cccgcgctt  tggaccttc  aaacaggct  caccgtgtg  gacgaaggc  1020
tgcgcagcc  caagggcat  ggggatgaa  ctctgccca  ggtcctggt  ggcgtgttc  1080
tcgaacagc  cacgccgtt  gtgtccctg  tcttccagc  gctcctgcg  ctccactac  1140
cccagaaac  catgcgact  ttcatccac  accacgagc  gcaccacaa  gctcaggtg  1200
aagagttcc  ggcacagca  ggcagcgag  accagtctg  gaagctggt  ggccctgag  1260
tgcggatgg  gaatgcaga  gccaggaac  tgggcgcag  cctgtgccg  caggaccgc  1320
gctgcacct  ctacttcag  gtggatgct  acgtggccc  gaccgagcc  aacagcctg  1380
ggctgctga  ccaacagaa  aagaatgtc  ttgccccgc  gatgacccg  catgggagg  1440
tgtggtcga  cttctgggg  gctctcagt  cagatggct  ctatgcccg  tccgaggac  1500
acgtggaca  tgtgcaggg  cggcgtgtt  gtgtctgga  tgtgcccta  atttcaaac  1560
tctacttga  caagggcag  gccctgcgg  gtgagctgc  gtcctcaga  ctcttccac  1620
acagcaagc  ggaccccga  atggccttc  gtgccaaca  ccggcagca  gatgtgttc  1680
tgttcctga  caaccggca  acccttggc  atctgctct  cctagacag  taccgcacc  1740
cccacctgc  caacgacct  tgggaggtg  tcagcaacc  cgaggactg  aaggagaag  1800
acatccacc  gaactacac  aaagccctg  cagggaagc  ggtggagac  ccctgcccg  1860
atgtctatt  gttccccat  ttcacggag  tggcctgtg  tgagctggt  gaggagatg  1920
agcactttg  ccagtggtc  ctgggcaac  acaaggaca  ccgcatcca  ggtggctac  1980
agaacgtgc  gactattga  atccacatg  accagatcg  ctttgagcg  gagtggcac  2040
aattcctgc  ggagtacat  gcgcccatg  cggagaagc  ctaccccgg  tactacacc  2100
gggcccagt  tgacctggc  tttgtcgtc  gctacaagc  tgatgagca  ccctcactg  2160
tgccacacc  tgatgcctc  accttcacc  tcaacatcg  cctgaaccg  gtcggggtg  2220
attacgagg  cgggggctg  cggttcctg  gctacaact  ttccatccg  gccccaagg  2280
agggctgga  cctcatgca  cctggacga  tcacgcatt  ccatgaggg  ctccccacc  2340
ccaggggca  ccgctacat  gcagtctcc  tcgtcgatc  ctaattggc  aggcctgac  2400
ctcttggac  tttcttctt  gccgacaac  actgcccag  agcctctgg  acctcgggg  2460
cccagggaa  ccagtccag  ctcctggct  ttgacttcc  attgctctt  gagccacca  2520
tcaaagaga  tcaaagaga  tcctgcagg  cagaggccg  aacacacct  tatggctgg  2580
gctctccgt  gtgttctgg  cccagcccc  ggagacacc  ttcactttt  ctgctttgt  2640
gtgactcgt  ctctccaac  tgtcttcct  aaaaaccaa  gcccccttc  cccacctct  2700
ccatggggt  agacttgag  agaacaggg  cttccccaa  ttgcccaga  agactgtct  2760
ggtgagaag  catggccag  gcttctccc  ggcacaggt  ttgcaccag  gacttctgc  2820
tcaagtttt  gggtaaaga  acctggatc  gactccaag  gctgccctg  gtctgggac  2880
tctgcctcc  tggctggtc  tgagagcaa  ccgtagtcc  ctggagaca  ccactccag  2940
gaacctctt  ggagacaga  gaggcatct  tgcacagct  gatcttcta  ttgcctgtg  3000
ggaggggag  gacaggtcc  cacaccaca  tgggtcacc  tgtcctgga  gcctctgaa  3060
agagggaca  accgtcaga  actggagag  ttctattaa  ggtcattta  accac  3115



<210> 3063
<211> 727
<212> PRT
<213> Homo sapiens
<308> Q02809
<400> 3063

Met Arg Pro Leu Leu Leu Leu Ala Leu Leu Gly Trp Leu Leu Leu Ala 
  1               5                  10                  15
Glu Ala Lys Gly Asp Ala Lys Pro Glu Asp Asn Leu Leu Val Leu Thr 
             20                  25                  30
Val Ala Thr Lys Glu Thr Glu Gly Phe Arg Arg Phe Lys Arg Ser Ala 
         35                  40                  45
Gln Phe Phe Asn Tyr Lys Ile Gln Ala Leu Gly Leu Gly Glu Asp Trp 
     50                  55                  60
Asn Val Glu Lys Gly Thr Ser Ala Gly Gly Gly Gln Lys Val Arg Leu 
 65                  70                  75                  80
Leu Lys Lys Ala Leu Glu Lys His Ala Asp Lys Glu Asp Leu Val Ile 
                 85                  90                  95
Leu Phe Thr Asp Ser Tyr Asp Val Leu Phe Ala Ser Gly Pro Arg Glu 
             100                105                110
Leu Leu Lys Lys Phe Arg Gln Ala Arg Ser Gln Val Val Phe Ser Ala 
         115                120                125
Glu Glu Leu Ile Tyr Pro Asp Arg Arg Leu Glu Thr Lys Tyr Pro Val 
     130                135                140
Val Ser Asp Gly Lys Arg Phe Leu Gly Ser Gly Gly Phe Ile Gly Tyr 
 145                150                155                160
Ala Pro Asn Leu Ser Lys Leu Val Ala Glu Trp Glu Gly Gln Asp Ser 
                 165                170                175
Asp Ser Asp Gln Leu Phe Tyr Thr Lys Ile Phe Leu Asp Pro Glu Lys 
             180                185                190
Arg Glu Gln Ile Asn Ile Thr Leu Asp His Arg Cys Arg Ile Phe Gln 
         195                200                205
Asn Leu Asp Gly Ala Leu Asp Glu Val Val Leu Lys Phe Glu Met Gly 
     210                215                220
His Val Arg Ala Arg Asn Leu Ala Tyr Asp Thr Leu Pro Val Leu Ile 
 225                230                235                240
His Gly Asn Gly Pro Thr Lys Leu Gln Leu Asn Tyr Leu Gly Asn Tyr 
                 245                250                255
Ile Pro Arg Phe Trp Thr Phe Glu Thr Gly Cys Thr Val Cys Asp Glu 
             260                265                270
Gly Leu Arg Ser Leu Lys Gly Ile Gly Asp Glu Ala Leu Pro Thr Val 
         275                280                285
Leu Val Gly Val Phe Ile Glu Gln Pro Thr Pro Phe Val Ser Leu Phe 
     290                295                300
Phe Gln Arg Leu Leu Arg Leu His Tyr Pro Gln Lys His Met Arg Leu 
 305                310                315                320
Phe Ile His Asn His Glu Gln His His Lys Ala Gln Val Glu Glu Phe 
                 325                330                335
Leu Ala Gln His Gly Ser Glu Tyr Gln Ser Val Lys Leu Val Gly Pro 
             340                345                350
Glu Val Arg Met Ala Asn Ala Asp Ala Arg Asn Met Gly Ala Asp Leu 
         355                360                365
Cys Arg Gln Asp Arg Ser Cys Thr Tyr Tyr Phe Ser Val Asp Ala Asp 
     370                375                380
Val Ala Leu Thr Glu Pro Asn Ser Leu Arg Leu Leu Ile Gln Gln Asn 
 385                390                395                400
Lys Asn Val Ile Ala Pro Leu Met Thr Arg His Gly Arg Leu Trp Ser 
                 405                410                415
Asn Phe Trp Gly Ala Leu Ser Ala Asp Gly Tyr Tyr Ala Arg Ser Glu 
             420                425                430
Asp Tyr Val Asp Ile Val Gln Gly Arg Arg Val Gly Val Trp Asn Val 
         435                440                445
Pro Tyr Ile Ser Asn Ile Tyr Leu Ile Lys Gly Ser Ala Leu Arg Gly 
     450                455                460
Glu Leu Gln Ser Ser Asp Leu Phe His His Ser Lys Leu Asp Pro Asp 
 465                470                475                480
Met Ala Phe Cys Ala Asn Ile Arg Gln Gln Asp Val Phe Met Phe Leu 
                 485                490                495
Thr Asn Arg His Thr Leu Gly His Leu Leu Ser Leu Asp Ser Tyr Arg 
             500                505                510
Thr Thr His Leu His Asn Asp Leu Trp Glu Val Phe Ser Asn Pro Glu 
         515                520                525
Asp Trp Lys Glu Lys Tyr Ile His Gln Asn Tyr Thr Lys Ala Leu Ala 
     530                535                540
Gly Lys Leu Val Glu Thr Pro Cys Pro Asp Val Tyr Trp Phe Pro Ile 
 545                550                555                560
Phe Thr Glu Val Ala Cys Asp Glu Leu Val Glu Glu Met Glu His Phe 
                 565                570                575
Gly Gln Trp Ser Leu Gly Asn Asn Lys Asp Asn Arg Ile Gln Gly Gly 
             580                585                590
Tyr Glu Asn Val Pro Thr Ile Asp Ile His Met Asn Gln Ile Gly Phe 
         595                600                605
Glu Arg Glu Trp His Lys Phe Leu Leu Glu Tyr Ile Ala Pro Met Thr 
     610                615                620
Glu Lys Leu Tyr Pro Gly Tyr Tyr Thr Arg Ala Gln Phe Asp Leu Ala 
 625                630                635                640
Phe Val Val Arg Tyr Lys Pro Asp Glu Gln Pro Ser Leu Met Pro His 
                 645                650                655
His Asp Ala Ser Thr Phe Thr Ile Asn Ile Ala Leu Asn Arg Val Gly 
             660                665                670
Val Asp Tyr Glu Gly Gly Gly Cys Arg Phe Leu Arg Tyr Asn Cys Ser 
         675                680                685
Ile Arg Ala Pro Arg Lys Gly Trp Thr Leu Met His Pro Gly Arg Leu 
     690                695                700
Thr His Tyr His Glu Gly Leu Pro Thr Thr Arg Gly Thr Arg Tyr Ile 
 705                710                715                720
Ala Val Ser Phe Val Asp Pro 
                 725



<210> 3064
<211> 2643
<212> DNA
<213> Rattus norvegicus
<308> L25387
<400> 3064

gtgaccagg  ctcttcgac  tccagcacc  cctttccga  gtacctgga  cacctctct  60
gggatggca  agcatggtg  cctgaccag  ggcggggag  cccaaggca  gaatgctgc  120
gtccgtgct  tggtgcgca  gggaatgta  acgggggcc  aagtgtact  tatatacga  180
ggttaccaa  gcatggtgg  tggaggctc  aatattgtg  aagccaagt  ggagtgtgt  240
tccagcatt  tacaagtgg  tgggaccat  atcggcagt  cccgttgcc  agccttccg  300
agccgtgaa  ggcgtctga  agccacctg  aacctggta  gcttgggca  aaccaacct  360
tgcgtgatc  gtggggacg  aagtctcac  ggagccaac  tcttccgga  ggagtggag  420
ggtcttctg  aagagctgg  taagaatgg  gagatcgat  cggacacag  gaagaagca  480
gcctacctc  acgtggtgg  catggtggg  tccattgac  atgacttct  tggcacaga  540
atgaccatc  gtacagatt  agctctgca  cgaattatt  aagttgttg  tgccatcat  600
accactgcc  agagccacc  gagaacctt  gtcttggag  tgatgggga  atactgtgg  660
tacttggcc  tggtgagcg  cttggcttg  ggtgccgac  gggtgttcc  tccagagtc  720
ccgccagag  aaggttggg  ggaagaaat  tgcctcaaa  tctccgaga  ccgtgcccg  780
aagaaaagg  tgaatatca  cattgtgtc  gaaggagca  tcgacaccc  aaataagcc  840
atcacctct  agaaaatca  ggagcttgt  gtgacaaat  tgggctttg  cacccgggt  900
accattctt  gacatgtcc  gagaggagg  accccttct  catttgaca  gattttggc  960
agccgtatg  gagtggagg  tgtccttgc  ttgctggaa  ctacccctg  gaccccagc  1020
tgtgtcgtg  cactgagag  aaatcaagc  gtacgcctg  ctctgatgg  gtgcgtgca  1080
atgacccag  atgtacaga  agcaatgga  gaaaggaga  ttgatgaag  cgtaaaact  1140
cgaggaagg  gttttgagg  caacctgaa  acctacaag  gtcttgcca  taaggagcc  1200
gatgacaag  tccccaaga  caattgcaa  gtagccatc  tcaatgtag  ggcacctgc  1260
gcgggaatg  atgcagccg  ccggtccgc  gttcgggtt  ggattgcag  gggccacaa  1320
atgttcgca  tctatgacg  ctttgatgg  ctcgccaat  gccaaatca  agaaatcgg  1380
tggggagat  tcggaggtt  gacaggaca  ggagggtcc  ttcttggga  gaaacgcac  1440
ctacccgga  agtacttgg  gaagatcgc  gaacagatg  actcgaaaa  tatcaatgc  1500
cttctgatc  ttggcggat  cgaggccta  ctgggactc  tagagctgg  agctgcccg  1560
aacaaacat  aggcattct  tgtccctat  gttatggtt  ctgctactg  ctccaacaa  1620
gtgccaggt  ctgatttca  catcggggc  gacacggct  tgaacacta  cacagacac  1680
tgcgaccgc  taaaacagt  agccagtgg  accaagcgc  gggtgttca  cattgagac  1740
atgggcgga  actgtggct  cctggccaa  atgggggga  ttgcagcgg  acgcgatgc  1800
gcctacatc  ttgaagaac  atttgatat  cgagatttg  agtccaacg  catgcactt  1860
acggagaaa  tgaagacca  catccagag  ggccttgtc  tcagaaatg  aaactgcag  1920
gtaaattac  ccacggact  catctacca  ctctactca  aggaaggga  aggagtgtt  1980
gactgcagg  agaacgtgc  aggccacat  cagcagggg  gagcacctt  tccattcga  2040
agaaacttt  gaaccaaaa  atctgccaa  gctatggag  ggatctcgg  caaactgaa  2100
ggctcccac  gcacaggga  aaaatttgt  agtgatgat  ccatttgtg  cctgggaat  2160
cagaagaga  acctcctgt  taaaccagt  gcagagcta  ggaaggcta  tgactttga  2220
caccgtatc  ccaaacaac  gtggtggct  aaactgcta  caatctcga  gatcttggc  2280
aagtatgag  caagctatg  catgtcaga  gtaggcaag  tggagccgg  gcataacca  2340
ggagaacta  cagccatct  attgaatat  ccgtctcct  acctgcaca  ttacctagg  2400
aagcctgta  tgttctcca  ggaccaccc  tttttgtaa  atagttatt  atcagcact  2460
tatgcaaga  ttgttggcc  agtattgtc  gcagtaata  tcagagagc  tcacttgct  2520
taaccattg  cgcaacaga  cctaagaca  gaaacccag  ctcgcgcga  tgatcacgt  2580
tcagttttc  actgtaccg  gtactactg  cttgtgctt  accatgtgt  tatcttgtg  2640
gat  2643



<210> 3065
<211> 786
<212> PRT
<213> Rattus norvegicus
<308> AAA17757
<400> 3065

Asp Gln Asp Ser Ser Thr Ser Ser Thr Ser Phe Pro Lys Tyr Leu Glu 
  1               5                  10                  15
His Leu Ser Gly Asp Gly Lys Ala Xaa Gly Val Leu Thr Ser Gly Gly 
             20                  25                  30
Glu Ser Gln Gly Met Asn Ala Ala Val Arg Ala Val Val Arg Met Gly 
         35                  40                  45
Met Tyr Thr Gly Ala Gln Val Tyr Phe Ile Tyr Glu Gly Tyr Gln Gly 
     50                  55                  60
Met Val Asp Gly Gly Ser Asn Ile Val Glu Ala Lys Trp Glu Cys Val 
 65                  70                  75                  80
Ser Ser Ile Leu Gln Val Gly Gly Thr Ile Ile Gly Ser Ala Arg Cys 
                 85                  90                  95
Gln Ala Phe Arg Ser Arg Glu Gly Arg Leu Lys Ala Thr Cys Asn Leu 
             100                105                110
Val Arg Leu Gly Ile Thr Asn Leu Cys Val Ile Gly Gly Asp Gly Ser 
         115                120                125
Leu Thr Gly Ala Asn Leu Phe Arg Lys Glu Trp Ser Gly Leu Leu Glu 
     130                135                140
Glu Leu Ala Lys Asn Gly Glu Ile Asp Ser Asp Thr Val Lys Lys His 
 145                150                155                160
Ala Tyr Leu Asn Val Val Gly Met Val Gly Ser Ile Asp Asn Asp Phe 
                 165                170                175
Cys Gly Thr Asp Met Thr Ile Gly Thr Asp Ser Ala Leu His Arg Ile 
             180                185                190
Ile Glu Val Val Asp Ala Ile Met Thr Thr Ala Gln Ser His Gln Arg 
         195                200                205
Thr Phe Val Leu Glu Val Met Gly Arg Tyr Cys Gly Tyr Leu Ala Leu 
     210                215                220
Val Ser Ala Leu Ala Cys Gly Ala Asp Trp Val Phe Leu Pro Glu Ser 
 225                230                235                240
Pro Pro Glu Glu Gly Trp Glu Glu Glu Met Cys Leu Lys Leu Ser Glu 
                 245                250                255
Asn Arg Ala Arg Lys Lys Arg Leu Asn Ile Ile Ile Val Ser Glu Gly 
             260                265                270
Ala Ile Asp Thr Gln Asn Lys Pro Ile Thr Ser Glu Lys Ile Lys Glu 
         275                280                285
Leu Val Val Thr Asn Leu Gly Phe Asp Thr Arg Val Thr Ile Leu Gly 
     290                295                300
His Val Gln Arg Gly Gly Thr Pro Ser Ala Phe Asp Arg Ile Leu Ala 
 305                310                315                320
Ser Arg Met Gly Val Glu Ala Val Leu Ala Leu Leu Glu Ala Thr Pro 
                 325                330                335
Glu Thr Pro Ala Cys Val Val Ser Leu Arg Gly Asn Gln Ala Val Arg 
             340                345                350
Leu Pro Leu Met Glu Cys Val Gln Met Thr Gln Asp Val Gln Lys Ala 
         355                360                365
Met Asp Glu Arg Arg Phe Asp Glu Ala Val Lys Leu Arg Gly Arg Ser 
     370                375                380
Phe Glu Gly Asn Leu Asn Thr Tyr Lys Arg Leu Ala Ile Lys Glu Pro 
 385                390                395                400
Asp Asp Lys Ile Pro Lys Ser Asn Cys Asn Val Ala Ile Ile Asn Val 
                 405                410                415
Gly Ala Pro Ala Ala Gly Met Asn Ala Ala Val Arg Ser Ala Val Arg 
             420                425                430
Val Gly Ile Ala Glu Gly His Lys Met Phe Ala Ile Tyr Asp Gly Phe 
         435                440                445
Asp Gly Leu Ala Asn Gly Gln Ile Lys Glu Ile Gly Trp Gly Asp Val 
     450                455                460
Gly Gly Trp Thr Gly Gln Gly Gly Ser Ile Leu Gly Thr Lys Arg Thr 
 465                470                475                480
Leu Pro Gly Lys Tyr Leu Glu Lys Ile Ala Glu Gln Met His Ser Lys 
                 485                490                495
Asn Ile Asn Ala Leu Leu Ile Ile Gly Gly Phe Glu Ala Tyr Leu Gly 
             500                505                510
Leu Leu Glu Leu Ala Ala Ala Arg Asn Lys His Glu Ala Phe Cys Val 
         515                520                525
Pro Met Val Met Val Pro Ala Thr Val Ser Asn Asn Val Pro Gly Ser 
     530                535                540
Asp Phe Ser Ile Gly Ala Asp Thr Ala Leu Asn Thr Ile Thr Asp Thr 
 545                550                555                560
Cys Asp Arg Ile Lys Gln Ser Ala Ser Gly Thr Lys Arg Arg Val Phe 
                 565                570                575
Ile Ile Glu Thr Met Gly Gly Tyr Cys Gly Tyr Leu Ala Asn Met Gly 
             580                585                590
Gly Leu Ala Ala Gly Arg Asp Ala Ala Tyr Ile Phe Glu Glu Gln Phe 
         595                600                605
Asp Ile Arg Asp Leu Gln Ser Asn Val Met His Leu Thr Glu Lys Met 
     610                615                620
Lys Thr Ser Ile Gln Arg Gly Leu Val Leu Arg Asn Glu Asn Cys Ser 
 625                630                635                640
Val Asn Tyr Thr Thr Asp Phe Ile Tyr Gln Leu Tyr Ser Glu Glu Gly 
                 645                650                655
Lys Gly Val Phe Asp Cys Arg Lys Asn Val Leu Gly His Met Gln Gln 
             660                665                670
Gly Gly Ala Pro Ser Pro Phe Asp Arg Asn Phe Gly Thr Lys Ile Ser 
         675                680                685
Ala Lys Ala Met Glu Trp Ile Ser Ala Lys Leu Lys Gly Ser His Gly 
     690                695                700
Thr Gly Lys Lys Phe Val Ser Asp Asp Ser Ile Cys Val Leu Gly Ile 
 705                710                715                720
Gln Lys Arg Asp Leu Leu Phe Lys Pro Val Ala Glu Leu Arg Lys Ala 
                 725                730                735
Thr Asp Phe Glu His Arg Ile Pro Lys Gln Gln Trp Trp Leu Lys Leu 
             740                745                750
Leu Pro Ile Ser Lys Ile Leu Ala Lys Tyr Glu Ala Ser Tyr Asp Met 
         755                760                765
Ser Asp Val Gly Lys Leu Glu Pro Val His Asn His Gly Glu Leu Ser 
     770                775                780
Ala Ile 
 785



<210> 3066
<211> 2591
<212> DNA
<213> Homo sapiens
<308> D25328
<400> 3066

cccggacgt  cggctcccc  cggcctcct  gccatggac  cggacgact  ccgggcccc  60
aagggctcc  tgcggaagt  cctggagca  ctctccggg  ccggcaagg  catcggcgt  120
ctgaccagc  gcggggatg  tcaaggtat  aacgctgcc  tccgtgccg  ggtgcgcat  180
ggtatctac  tgggggcca  ggtgtactt  atctacgag  gctaccagg  catggtgga  240
ggaggctca  acatcgcag  ggccgactg  gagagtgtc  ccagcatcc  gcaagtggg  300
gggacgatc  ttggcagtg  gcggtgcca  gccttccgc  cgcgggaag  ccgcctgaa  360
gctgcttgc  acctgctgc  gcgcggcat  accaacctg  gtgtgatcg  cggggacgg  420
agcctcacc  gggccaacc  cttccggaa  gagtggagt  ggctgctgg  ggagctggc  480
aggaacggc  agatcgata  ggaggccgt  cagaagtac  cctacctca  cgtggtggg  540
atggtgggc  ccatcgaca  tgatttctg  ggcaccgac  tgaccatcg  cacggactc  600
gccctgcac  ggatcatcg  ggtcgtcga  gccatcatg  ccacggccc  gagccacca  660
aggaccttc  ttctggagg  gatgggacg  cactgtggg  acctggccc  ggtgagtgc  720
ttggcctgc  gtgcggact  ggtgttcct  ccagaatct  caccagagg  aggctggga  780
gagcagatg  gtgtcaaac  ctcggagaa  cgtgcccgg  aaaaaaggc  gaatattat  840
attgtggct  aaggagcaa  tgataccca  aataaaccc  tcacctctg  gaaaatcaa  900
gagcttgtc  tcacgcagc  gggctatga  acacgtgtg  ccatcctcg  gcacgtgca  960
agaggaggg  ccccttcgg  attcgacag  atcttggcc  gccgcatgg  agtggaggc  1020
gtcatcgcc  tgctagagg  caccccgga  accccagct  gcgtcgtgt  actgaacgg  1080
aaccacgcc  tgcgcctgc  gctgatgga  tgcgtgcag  tgactcagg  tgtgcagaa  1140
gcgatggac  agaggagat  tcaagatgc  gttcgactc  gagggagga  ctttgcggg  1200
aacctgaac  cctacaagc  acttgccat  aagctgccg  atgatcaga  cccaaagac  1260
aattgcaac  tagctgtca  caacgtggg  gcacccgcg  ctgggatga  cgcggccgt  1320
cgctcagct  tgcgcgtgg  cattgccga  ggccacagg  tgctcgcca  ctatgatgg  1380
tttgacggc  tcgccaagg  ccagatcaa  gaaatcggc  ggacagatg  cgggggctg  1440
accggccaa  gaggctcca  tcttgggac  aaacgcgtt  tcccgggga  gtacttgga  1500
gagatcgcc  cacagatgc  cacgcacag  atcaacgcg  tgctgatca  cggtggatt  1560
gaggcctac  tgggactcc  ggagctgtc  gccgcccgg  agaagcacg  ggagttctg  1620
gtccccatg  tcatggttc  cgctactgt  tccaacaat  tgccgggtt  cgatttcag  1680
atcggggca  acaccgccc  gaacactat  accgacacc  gcgaccgca  caagcagtc  1740
gccagcgga  ccaagcggc  cgtgttcat  atcgagacc  tgggcggct  ctgtggcta  1800
ctggccaac  tgggggggc  cgcggccgg  gctgatgcc  catacattt  cgaagagcc  1860
ttcgacatc  gggatctgc  gtccaacgt  gagcacctg  cggagaaaa  gaagaccac  1920
atccagaga  gccttgtgc  cagaaatga  agctgcagt  aaaactaca  caccgactt  1980
atttaccag  tgtattcag  agagggcaa  ggcgtgttt  actgcagga  gaacgtgct  2040
ggtcacatg  agcagggtg  ggcaccctc  ccatttgat  gaaactttg  aaccaaaat  2100
tctgccaga  ctatggagt  gatcactgc  aaactcaag  aggcccggg  cagaggaaa  2160
aaatttacc  ccgatgatt  catttgtgt  ctgggaata  gcaaaagaa  cgttatttt  2220
caacctgtg  cagagctga  gaagcaaac  gattttgag  acaggattc  caaagaaca  2280
tggtggctc  agctacggc  cctcatgaa  atcctggcc  agtacaagg  cagctatga  2340
gtgtcggac  caggccagc  ggaacatgt  cagccctgg  gtgtctgac  cagtcccgc  2400
tgcatgtgc  tgcagccac  gtggactgt  tgtttttgt  acacttaag  tattttatc  2460
gcactttat  cacgtatta  tgacattaa  acctaatcg  cgagtgccc  tctgcccca  2520
cagctccag  gcgtgctgt  tgtggagtg  gtctcatgc  ttcagatgt  catatgagc  2580
gaattaatt  a  2591



<210> 3067
<211> 784
<212> PRT
<213> Homo sapiens
<308> Q01813
<400> 3067

Met Asp Ala Asp Asp Ser Arg Ala Pro Lys Gly Ser Leu Arg Lys Phe 
  1               5                  10                  15
Leu Glu His Leu Ser Gly Ala Gly Lys Ala Ile Gly Val Leu Thr Ser 
             20                  25                  30
Gly Gly Asp Ala Gln Gly Met Asn Ala Ala Val Arg Ala Val Val Arg 
         35                  40                  45
Met Gly Ile Tyr Val Gly Ala Lys Val Tyr Phe Ile Tyr Glu Gly Tyr 
     50                  55                  60
Gln Gly Met Val Asp Gly Gly Ser Asn Ile Ala Glu Ala Asp Trp Glu 
 65                  70                  75                  80
Ser Val Ser Ser Ile Leu Gln Val Gly Gly Thr Ile Ile Gly Ser Ala 
                 85                  90                  95
Arg Cys Gln Ala Phe Arg Thr Arg Glu Gly Arg Leu Lys Ala Ala Cys 
             100                105                110
Asn Leu Leu Gln Arg Gly Ile Thr Asn Leu Cys Val Ile Gly Gly Asp 
         115                120                125
Gly Ser Leu Thr Gly Ala Asn Leu Phe Arg Lys Glu Trp Ser Gly Leu 
     130                135                140
Leu Glu Glu Leu Ala Arg Asn Gly Gln Ile Asp Lys Glu Ala Val Gln 
 145                150                155                160
Lys Tyr Ala Tyr Leu Asn Val Val Gly Met Val Gly Ser Ile Asp Asn 
                 165                170                175
Asp Phe Cys Gly Thr Asp Met Thr Ile Gly Thr Asp Ser Ala Leu His 
             180                185                190
Arg Ile Ile Glu Val Val Asp Ala Ile Met Thr Thr Ala Gln Ser His 
         195                200                205
Gln Arg Thr Phe Val Leu Glu Val Met Gly Arg His Cys Gly Tyr Leu 
     210                215                220
Ala Leu Val Ser Ala Leu Ala Cys Gly Ala Asp Trp Val Phe Leu Pro 
 225                230                235                240
Glu Ser Pro Pro Glu Glu Gly Trp Glu Glu Gln Met Cys Val Lys Leu 
                 245                250                255
Ser Glu Asn Arg Ala Arg Lys Lys Arg Leu Asn Ile Ile Ile Val Ala 
             260                265                270
Glu Gly Ala Ile Asp Thr Gln Asn Lys Pro Ile Thr Ser Glu Lys Ile 
         275                280                285
Lys Glu Leu Val Val Thr Gln Leu Gly Tyr Asp Thr Arg Val Thr Ile 
     290                295                300
Leu Gly His Val Gln Arg Gly Gly Thr Pro Ser Ala Phe Asp Arg Ile 
 305                310                315                320
Leu Ala Ser Arg Met Gly Val Glu Ala Val Ile Ala Leu Leu Glu Ala 
                 325                330                335
Thr Pro Asp Thr Pro Ala Cys Val Val Ser Leu Asn Gly Asn His Ala 
             340                345                350
Val Arg Leu Pro Leu Met Glu Cys Val Gln Met Thr Gln Asp Val Gln 
         355                360                365
Lys Ala Met Asp Glu Arg Arg Phe Gln Asp Ala Val Arg Leu Arg Gly 
     370                375                380
Arg Ser Phe Ala Gly Asn Leu Asn Thr Tyr Lys Arg Leu Ala Ile Lys 
 385                390                395                400
Leu Pro Asp Asp Gln Ile Pro Lys Thr Asn Cys Asn Val Ala Val Ile 
                 405                410                415
Asn Val Gly Ala Pro Ala Ala Gly Met Asn Ala Ala Val Arg Ser Ala 
             420                425                430
Val Arg Val Gly Ile Ala Asp Gly His Arg Met Leu Ala Ile Tyr Asp 
         435                440                445
Gly Phe Asp Gly Phe Ala Lys Gly Gln Ile Lys Glu Ile Gly Trp Thr 
     450                455                460
Asp Val Gly Gly Trp Thr Gly Gln Gly Gly Ser Ile Leu Gly Thr Lys 
 465                470                475                480
Arg Val Leu Pro Gly Lys Tyr Leu Glu Glu Ile Ala Thr Gln Met Arg 
                 485                490                495
Thr His Ser Ile Asn Ala Leu Leu Ile Ile Gly Gly Phe Glu Ala Tyr 
             500                505                510
Leu Gly Leu Leu Glu Leu Ser Ala Ala Arg Glu Lys His Glu Glu Phe 
         515                520                525
Cys Val Pro Met Val Met Val Pro Ala Thr Val Ser Asn Asn Val Pro 
     530                535                540
Gly Ser Asp Phe Ser Ile Gly Ala Asp Thr Ala Leu Asn Thr Ile Thr 
 545                550                555                560
Asp Thr Cys Asp Arg Ile Lys Gln Ser Ala Ser Gly Thr Lys Arg Arg 
                 565                570                575
Val Phe Ile Ile Glu Thr Met Gly Gly Tyr Cys Gly Tyr Leu Ala Asn 
             580                585                590
Met Gly Gly Leu Ala Ala Gly Ala Asp Ala Ala Tyr Ile Phe Glu Glu 
         595                600                605
Pro Phe Asp Ile Arg Asp Leu Gln Ser Asn Val Glu His Leu Thr Glu 
     610                615                620
Lys Met Lys Thr Thr Ile Gln Arg Gly Leu Val Leu Arg Asn Glu Ser 
 625                630                635                640
Cys Ser Glu Asn Tyr Thr Thr Asp Phe Ile Tyr Gln Leu Tyr Ser Glu 
                 645                650                655
Glu Gly Lys Gly Val Phe Asp Cys Arg Lys Asn Val Leu Gly His Met 
             660                665                670
Gln Gln Gly Gly Ala Pro Ser Pro Phe Asp Arg Asn Phe Gly Thr Lys 
         675                680                685
Ile Ser Ala Arg Ala Met Glu Trp Ile Thr Ala Lys Leu Lys Glu Ala 
     690                695                700
Arg Gly Arg Gly Lys Lys Phe Thr Thr Asp Asp Ser Ile Cys Val Leu 
 705                710                715                720
Gly Ile Ser Lys Arg Asn Val Ile Phe Gln Pro Val Ala Glu Leu Lys 
                 725                730                735
Lys Gln Thr Asp Phe Glu His Arg Ile Pro Lys Glu Gln Trp Trp Leu 
             740                745                750
Lys Leu Arg Pro Leu Met Lys Ile Leu Ala Lys Tyr Lys Ala Ser Tyr 
         755                760                765
Asp Val Ser Asp Ser Gly Gln Leu Glu His Val Gln Pro Trp Ser Val 
     770                775                780



<210> 3068
<211> 2643
<212> DNA
<213> Rattus norvegicus
<308> L25387
<400> 3068

gtgaccagg  ctcttcgac  tccagcacc  cctttccga  gtacctgga  cacctctct  60
gggatggca  agcatggtg  cctgaccag  ggcggggag  cccaaggca  gaatgctgc  120
gtccgtgct  tggtgcgca  gggaatgta  acgggggcc  aagtgtact  tatatacga  180
ggttaccaa  gcatggtgg  tggaggctc  aatattgtg  aagccaagt  ggagtgtgt  240
tccagcatt  tacaagtgg  tgggaccat  atcggcagt  cccgttgcc  agccttccg  300
agccgtgaa  ggcgtctga  agccacctg  aacctggta  gcttgggca  aaccaacct  360
tgcgtgatc  gtggggacg  aagtctcac  ggagccaac  tcttccgga  ggagtggag  420
ggtcttctg  aagagctgg  taagaatgg  gagatcgat  cggacacag  gaagaagca  480
gcctacctc  acgtggtgg  catggtggg  tccattgac  atgacttct  tggcacaga  540
atgaccatc  gtacagatt  agctctgca  cgaattatt  aagttgttg  tgccatcat  600
accactgcc  agagccacc  gagaacctt  gtcttggag  tgatgggga  atactgtgg  660
tacttggcc  tggtgagcg  cttggcttg  ggtgccgac  gggtgttcc  tccagagtc  720
ccgccagag  aaggttggg  ggaagaaat  tgcctcaaa  tctccgaga  ccgtgcccg  780
aagaaaagg  tgaatatca  cattgtgtc  gaaggagca  tcgacaccc  aaataagcc  840
atcacctct  agaaaatca  ggagcttgt  gtgacaaat  tgggctttg  cacccgggt  900
accattctt  gacatgtcc  gagaggagg  accccttct  catttgaca  gattttggc  960
agccgtatg  gagtggagg  tgtccttgc  ttgctggaa  ctacccctg  gaccccagc  1020
tgtgtcgtg  cactgagag  aaatcaagc  gtacgcctg  ctctgatgg  gtgcgtgca  1080
atgacccag  atgtacaga  agcaatgga  gaaaggaga  ttgatgaag  cgtaaaact  1140
cgaggaagg  gttttgagg  caacctgaa  acctacaag  gtcttgcca  taaggagcc  1200
gatgacaag  tccccaaga  caattgcaa  gtagccatc  tcaatgtag  ggcacctgc  1260
gcgggaatg  atgcagccg  ccggtccgc  gttcgggtt  ggattgcag  gggccacaa  1320
atgttcgca  tctatgacg  ctttgatgg  ctcgccaat  gccaaatca  agaaatcgg  1380
tggggagat  tcggaggtt  gacaggaca  ggagggtcc  ttcttggga  gaaacgcac  1440
ctacccgga  agtacttgg  gaagatcgc  gaacagatg  actcgaaaa  tatcaatgc  1500
cttctgatc  ttggcggat  cgaggccta  ctgggactc  tagagctgg  agctgcccg  1560
aacaaacat  aggcattct  tgtccctat  gttatggtt  ctgctactg  ctccaacaa  1620
gtgccaggt  ctgatttca  catcggggc  gacacggct  tgaacacta  cacagacac  1680
tgcgaccgc  taaaacagt  agccagtgg  accaagcgc  gggtgttca  cattgagac  1740
atgggcgga  actgtggct  cctggccaa  atgggggga  ttgcagcgg  acgcgatgc  1800
gcctacatc  ttgaagaac  atttgatat  cgagatttg  agtccaacg  catgcactt  1860
acggagaaa  tgaagacca  catccagag  ggccttgtc  tcagaaatg  aaactgcag  1920
gtaaattac  ccacggact  catctacca  ctctactca  aggaaggga  aggagtgtt  1980
gactgcagg  agaacgtgc  aggccacat  cagcagggg  gagcacctt  tccattcga  2040
agaaacttt  gaaccaaaa  atctgccaa  gctatggag  ggatctcgg  caaactgaa  2100
ggctcccac  gcacaggga  aaaatttgt  agtgatgat  ccatttgtg  cctgggaat  2160
cagaagaga  acctcctgt  taaaccagt  gcagagcta  ggaaggcta  tgactttga  2220
caccgtatc  ccaaacaac  gtggtggct  aaactgcta  caatctcga  gatcttggc  2280
aagtatgag  caagctatg  catgtcaga  gtaggcaag  tggagccgg  gcataacca  2340
ggagaacta  cagccatct  attgaatat  ccgtctcct  acctgcaca  ttacctagg  2400
aagcctgta  tgttctcca  ggaccaccc  tttttgtaa  atagttatt  atcagcact  2460
tatgcaaga  ttgttggcc  agtattgtc  gcagtaata  tcagagagc  tcacttgct  2520
taaccattg  cgcaacaga  cctaagaca  gaaacccag  ctcgcgcga  tgatcacgt  2580
tcagttttc  actgtaccg  gtactactg  cttgtgctt  accatgtgt  tatcttgtg  2640
gat  2643



<210> 3069
<211> 786
<212> PRT
<213> Rattus norvegicus
<308> AAA17757
<400> 3069

Asp Gln Asp Ser Ser Thr Ser Ser Thr Ser Phe Pro Lys Tyr Leu Glu 
  1               5                  10                  15
His Leu Ser Gly Asp Gly Lys Ala Xaa Gly Val Leu Thr Ser Gly Gly 
             20                  25                  30
Glu Ser Gln Gly Met Asn Ala Ala Val Arg Ala Val Val Arg Met Gly 
         35                  40                  45
Met Tyr Thr Gly Ala Gln Val Tyr Phe Ile Tyr Glu Gly Tyr Gln Gly 
     50                  55                  60
Met Val Asp Gly Gly Ser Asn Ile Val Glu Ala Lys Trp Glu Cys Val 
 65                  70                  75                  80
Ser Ser Ile Leu Gln Val Gly Gly Thr Ile Ile Gly Ser Ala Arg Cys 
                 85                  90                  95
Gln Ala Phe Arg Ser Arg Glu Gly Arg Leu Lys Ala Thr Cys Asn Leu 
             100                105                110
Val Arg Leu Gly Ile Thr Asn Leu Cys Val Ile Gly Gly Asp Gly Ser 
         115                120                125
Leu Thr Gly Ala Asn Leu Phe Arg Lys Glu Trp Ser Gly Leu Leu Glu 
     130                135                140
Glu Leu Ala Lys Asn Gly Glu Ile Asp Ser Asp Thr Val Lys Lys His 
 145                150                155                160
Ala Tyr Leu Asn Val Val Gly Met Val Gly Ser Ile Asp Asn Asp Phe 
                 165                170                175
Cys Gly Thr Asp Met Thr Ile Gly Thr Asp Ser Ala Leu His Arg Ile 
             180                185                190
Ile Glu Val Val Asp Ala Ile Met Thr Thr Ala Gln Ser His Gln Arg 
         195                200                205
Thr Phe Val Leu Glu Val Met Gly Arg Tyr Cys Gly Tyr Leu Ala Leu 
     210                215                220
Val Ser Ala Leu Ala Cys Gly Ala Asp Trp Val Phe Leu Pro Glu Ser 
 225                230                235                240
Pro Pro Glu Glu Gly Trp Glu Glu Glu Met Cys Leu Lys Leu Ser Glu 
                 245                250                255
Asn Arg Ala Arg Lys Lys Arg Leu Asn Ile Ile Ile Val Ser Glu Gly 
             260                265                270
Ala Ile Asp Thr Gln Asn Lys Pro Ile Thr Ser Glu Lys Ile Lys Glu 
         275                280                285
Leu Val Val Thr Asn Leu Gly Phe Asp Thr Arg Val Thr Ile Leu Gly 
     290                295                300
His Val Gln Arg Gly Gly Thr Pro Ser Ala Phe Asp Arg Ile Leu Ala 
 305                310                315                320
Ser Arg Met Gly Val Glu Ala Val Leu Ala Leu Leu Glu Ala Thr Pro 
                 325                330                335
Glu Thr Pro Ala Cys Val Val Ser Leu Arg Gly Asn Gln Ala Val Arg 
             340                345                350
Leu Pro Leu Met Glu Cys Val Gln Met Thr Gln Asp Val Gln Lys Ala 
         355                360                365
Met Asp Glu Arg Arg Phe Asp Glu Ala Val Lys Leu Arg Gly Arg Ser 
     370                375                380
Phe Glu Gly Asn Leu Asn Thr Tyr Lys Arg Leu Ala Ile Lys Glu Pro 
 385                390                395                400
Asp Asp Lys Ile Pro Lys Ser Asn Cys Asn Val Ala Ile Ile Asn Val 
                 405                410                415
Gly Ala Pro Ala Ala Gly Met Asn Ala Ala Val Arg Ser Ala Val Arg 
             420                425                430
Val Gly Ile Ala Glu Gly His Lys Met Phe Ala Ile Tyr Asp Gly Phe 
         435                440                445
Asp Gly Leu Ala Asn Gly Gln Ile Lys Glu Ile Gly Trp Gly Asp Val 
     450                455                460
Gly Gly Trp Thr Gly Gln Gly Gly Ser Ile Leu Gly Thr Lys Arg Thr 
 465                470                475                480
Leu Pro Gly Lys Tyr Leu Glu Lys Ile Ala Glu Gln Met His Ser Lys 
                 485                490                495
Asn Ile Asn Ala Leu Leu Ile Ile Gly Gly Phe Glu Ala Tyr Leu Gly 
             500                505                510
Leu Leu Glu Leu Ala Ala Ala Arg Asn Lys His Glu Ala Phe Cys Val 
         515                520                525
Pro Met Val Met Val Pro Ala Thr Val Ser Asn Asn Val Pro Gly Ser 
     530                535                540
Asp Phe Ser Ile Gly Ala Asp Thr Ala Leu Asn Thr Ile Thr Asp Thr 
 545                550                555                560
Cys Asp Arg Ile Lys Gln Ser Ala Ser Gly Thr Lys Arg Arg Val Phe 
                 565                570                575
Ile Ile Glu Thr Met Gly Gly Tyr Cys Gly Tyr Leu Ala Asn Met Gly 
             580                585                590
Gly Leu Ala Ala Gly Arg Asp Ala Ala Tyr Ile Phe Glu Glu Gln Phe 
         595                600                605
Asp Ile Arg Asp Leu Gln Ser Asn Val Met His Leu Thr Glu Lys Met 
     610                615                620
Lys Thr Ser Ile Gln Arg Gly Leu Val Leu Arg Asn Glu Asn Cys Ser 
 625                630                635                640
Val Asn Tyr Thr Thr Asp Phe Ile Tyr Gln Leu Tyr Ser Glu Glu Gly 
                 645                650                655
Lys Gly Val Phe Asp Cys Arg Lys Asn Val Leu Gly His Met Gln Gln 
             660                665                670
Gly Gly Ala Pro Ser Pro Phe Asp Arg Asn Phe Gly Thr Lys Ile Ser 
         675                680                685
Ala Lys Ala Met Glu Trp Ile Ser Ala Lys Leu Lys Gly Ser His Gly 
     690                695                700
Thr Gly Lys Lys Phe Val Ser Asp Asp Ser Ile Cys Val Leu Gly Ile 
 705                710                715                720
Gln Lys Arg Asp Leu Leu Phe Lys Pro Val Ala Glu Leu Arg Lys Ala 
                 725                730                735
Thr Asp Phe Glu His Arg Ile Pro Lys Gln Gln Trp Trp Leu Lys Leu 
             740                745                750
Leu Pro Ile Ser Lys Ile Leu Ala Lys Tyr Glu Ala Ser Tyr Asp Met 
         755                760                765
Ser Asp Val Gly Lys Leu Glu Pro Val His Asn His Gly Glu Leu Ser 
     770                775                780
Ala Ile 
 785



<210> 3070
<211> 2591
<212> DNA
<213> Homo sapiens
<308> D25328
<400> 3070

cccggacgt  cggctcccc  cggcctcct  gccatggac  cggacgact  ccgggcccc  60
aagggctcc  tgcggaagt  cctggagca  ctctccggg  ccggcaagg  catcggcgt  120
ctgaccagc  gcggggatg  tcaaggtat  aacgctgcc  tccgtgccg  ggtgcgcat  180
ggtatctac  tgggggcca  ggtgtactt  atctacgag  gctaccagg  catggtgga  240
ggaggctca  acatcgcag  ggccgactg  gagagtgtc  ccagcatcc  gcaagtggg  300
gggacgatc  ttggcagtg  gcggtgcca  gccttccgc  cgcgggaag  ccgcctgaa  360
gctgcttgc  acctgctgc  gcgcggcat  accaacctg  gtgtgatcg  cggggacgg  420
agcctcacc  gggccaacc  cttccggaa  gagtggagt  ggctgctgg  ggagctggc  480
aggaacggc  agatcgata  ggaggccgt  cagaagtac  cctacctca  cgtggtggg  540
atggtgggc  ccatcgaca  tgatttctg  ggcaccgac  tgaccatcg  cacggactc  600
gccctgcac  ggatcatcg  ggtcgtcga  gccatcatg  ccacggccc  gagccacca  660
aggaccttc  ttctggagg  gatgggacg  cactgtggg  acctggccc  ggtgagtgc  720
ttggcctgc  gtgcggact  ggtgttcct  ccagaatct  caccagagg  aggctggga  780
gagcagatg  gtgtcaaac  ctcggagaa  cgtgcccgg  aaaaaaggc  gaatattat  840
attgtggct  aaggagcaa  tgataccca  aataaaccc  tcacctctg  gaaaatcaa  900
gagcttgtc  tcacgcagc  gggctatga  acacgtgtg  ccatcctcg  gcacgtgca  960
agaggaggg  ccccttcgg  attcgacag  atcttggcc  gccgcatgg  agtggaggc  1020
gtcatcgcc  tgctagagg  caccccgga  accccagct  gcgtcgtgt  actgaacgg  1080
aaccacgcc  tgcgcctgc  gctgatgga  tgcgtgcag  tgactcagg  tgtgcagaa  1140
gcgatggac  agaggagat  tcaagatgc  gttcgactc  gagggagga  ctttgcggg  1200
aacctgaac  cctacaagc  acttgccat  aagctgccg  atgatcaga  cccaaagac  1260
aattgcaac  tagctgtca  caacgtggg  gcacccgcg  ctgggatga  cgcggccgt  1320
cgctcagct  tgcgcgtgg  cattgccga  ggccacagg  tgctcgcca  ctatgatgg  1380
tttgacggc  tcgccaagg  ccagatcaa  gaaatcggc  ggacagatg  cgggggctg  1440
accggccaa  gaggctcca  tcttgggac  aaacgcgtt  tcccgggga  gtacttgga  1500
gagatcgcc  cacagatgc  cacgcacag  atcaacgcg  tgctgatca  cggtggatt  1560
gaggcctac  tgggactcc  ggagctgtc  gccgcccgg  agaagcacg  ggagttctg  1620
gtccccatg  tcatggttc  cgctactgt  tccaacaat  tgccgggtt  cgatttcag  1680
atcggggca  acaccgccc  gaacactat  accgacacc  gcgaccgca  caagcagtc  1740
gccagcgga  ccaagcggc  cgtgttcat  atcgagacc  tgggcggct  ctgtggcta  1800
ctggccaac  tgggggggc  cgcggccgg  gctgatgcc  catacattt  cgaagagcc  1860
ttcgacatc  gggatctgc  gtccaacgt  gagcacctg  cggagaaaa  gaagaccac  1920
atccagaga  gccttgtgc  cagaaatga  agctgcagt  aaaactaca  caccgactt  1980
atttaccag  tgtattcag  agagggcaa  ggcgtgttt  actgcagga  gaacgtgct  2040
ggtcacatg  agcagggtg  ggcaccctc  ccatttgat  gaaactttg  aaccaaaat  2100
tctgccaga  ctatggagt  gatcactgc  aaactcaag  aggcccggg  cagaggaaa  2160
aaatttacc  ccgatgatt  catttgtgt  ctgggaata  gcaaaagaa  cgttatttt  2220
caacctgtg  cagagctga  gaagcaaac  gattttgag  acaggattc  caaagaaca  2280
tggtggctc  agctacggc  cctcatgaa  atcctggcc  agtacaagg  cagctatga  2340
gtgtcggac  caggccagc  ggaacatgt  cagccctgg  gtgtctgac  cagtcccgc  2400
tgcatgtgc  tgcagccac  gtggactgt  tgtttttgt  acacttaag  tattttatc  2460
gcactttat  cacgtatta  tgacattaa  acctaatcg  cgagtgccc  tctgcccca  2520
cagctccag  gcgtgctgt  tgtggagtg  gtctcatgc  ttcagatgt  catatgagc  2580
gaattaatt  a  2591



<210> 3071
<211> 784
<212> PRT
<213> Homo sapiens
<308> Q01813
<400> 3071

Met Asp Ala Asp Asp Ser Arg Ala Pro Lys Gly Ser Leu Arg Lys Phe 
  1               5                  10                  15
Leu Glu His Leu Ser Gly Ala Gly Lys Ala Ile Gly Val Leu Thr Ser 
             20                  25                  30
Gly Gly Asp Ala Gln Gly Met Asn Ala Ala Val Arg Ala Val Val Arg 
         35                  40                  45
Met Gly Ile Tyr Val Gly Ala Lys Val Tyr Phe Ile Tyr Glu Gly Tyr 
     50                  55                  60
Gln Gly Met Val Asp Gly Gly Ser Asn Ile Ala Glu Ala Asp Trp Glu 
 65                  70                  75                  80
Ser Val Ser Ser Ile Leu Gln Val Gly Gly Thr Ile Ile Gly Ser Ala 
                 85                  90                  95
Arg Cys Gln Ala Phe Arg Thr Arg Glu Gly Arg Leu Lys Ala Ala Cys 
             100                105                110
Asn Leu Leu Gln Arg Gly Ile Thr Asn Leu Cys Val Ile Gly Gly Asp 
         115                120                125
Gly Ser Leu Thr Gly Ala Asn Leu Phe Arg Lys Glu Trp Ser Gly Leu 
     130                135                140
Leu Glu Glu Leu Ala Arg Asn Gly Gln Ile Asp Lys Glu Ala Val Gln 
 145                150                155                160
Lys Tyr Ala Tyr Leu Asn Val Val Gly Met Val Gly Ser Ile Asp Asn 
                 165                170                175
Asp Phe Cys Gly Thr Asp Met Thr Ile Gly Thr Asp Ser Ala Leu His 
             180                185                190
Arg Ile Ile Glu Val Val Asp Ala Ile Met Thr Thr Ala Gln Ser His 
         195                200                205
Gln Arg Thr Phe Val Leu Glu Val Met Gly Arg His Cys Gly Tyr Leu 
     210                215                220
Ala Leu Val Ser Ala Leu Ala Cys Gly Ala Asp Trp Val Phe Leu Pro 
 225                230                235                240
Glu Ser Pro Pro Glu Glu Gly Trp Glu Glu Gln Met Cys Val Lys Leu 
                 245                250                255
Ser Glu Asn Arg Ala Arg Lys Lys Arg Leu Asn Ile Ile Ile Val Ala 
             260                265                270
Glu Gly Ala Ile Asp Thr Gln Asn Lys Pro Ile Thr Ser Glu Lys Ile 
         275                280                285
Lys Glu Leu Val Val Thr Gln Leu Gly Tyr Asp Thr Arg Val Thr Ile 
     290                295                300
Leu Gly His Val Gln Arg Gly Gly Thr Pro Ser Ala Phe Asp Arg Ile 
 305                310                315                320
Leu Ala Ser Arg Met Gly Val Glu Ala Val Ile Ala Leu Leu Glu Ala 
                 325                330                335
Thr Pro Asp Thr Pro Ala Cys Val Val Ser Leu Asn Gly Asn His Ala 
             340                345                350
Val Arg Leu Pro Leu Met Glu Cys Val Gln Met Thr Gln Asp Val Gln 
         355                360                365
Lys Ala Met Asp Glu Arg Arg Phe Gln Asp Ala Val Arg Leu Arg Gly 
     370                375                380
Arg Ser Phe Ala Gly Asn Leu Asn Thr Tyr Lys Arg Leu Ala Ile Lys 
 385                390                395                400
Leu Pro Asp Asp Gln Ile Pro Lys Thr Asn Cys Asn Val Ala Val Ile 
                 405                410                415
Asn Val Gly Ala Pro Ala Ala Gly Met Asn Ala Ala Val Arg Ser Ala 
             420                425                430
Val Arg Val Gly Ile Ala Asp Gly His Arg Met Leu Ala Ile Tyr Asp 
         435                440                445
Gly Phe Asp Gly Phe Ala Lys Gly Gln Ile Lys Glu Ile Gly Trp Thr 
     450                455                460
Asp Val Gly Gly Trp Thr Gly Gln Gly Gly Ser Ile Leu Gly Thr Lys 
 465                470                475                480
Arg Val Leu Pro Gly Lys Tyr Leu Glu Glu Ile Ala Thr Gln Met Arg 
                 485                490                495
Thr His Ser Ile Asn Ala Leu Leu Ile Ile Gly Gly Phe Glu Ala Tyr 
             500                505                510
Leu Gly Leu Leu Glu Leu Ser Ala Ala Arg Glu Lys His Glu Glu Phe 
         515                520                525
Cys Val Pro Met Val Met Val Pro Ala Thr Val Ser Asn Asn Val Pro 
     530                535                540
Gly Ser Asp Phe Ser Ile Gly Ala Asp Thr Ala Leu Asn Thr Ile Thr 
 545                550                555                560
Asp Thr Cys Asp Arg Ile Lys Gln Ser Ala Ser Gly Thr Lys Arg Arg 
                 565                570                575
Val Phe Ile Ile Glu Thr Met Gly Gly Tyr Cys Gly Tyr Leu Ala Asn 
             580                585                590
Met Gly Gly Leu Ala Ala Gly Ala Asp Ala Ala Tyr Ile Phe Glu Glu 
         595                600                605
Pro Phe Asp Ile Arg Asp Leu Gln Ser Asn Val Glu His Leu Thr Glu 
     610                615                620
Lys Met Lys Thr Thr Ile Gln Arg Gly Leu Val Leu Arg Asn Glu Ser 
 625                630                635                640
Cys Ser Glu Asn Tyr Thr Thr Asp Phe Ile Tyr Gln Leu Tyr Ser Glu 
                 645                650                655
Glu Gly Lys Gly Val Phe Asp Cys Arg Lys Asn Val Leu Gly His Met 
             660                665                670
Gln Gln Gly Gly Ala Pro Ser Pro Phe Asp Arg Asn Phe Gly Thr Lys 
         675                680                685
Ile Ser Ala Arg Ala Met Glu Trp Ile Thr Ala Lys Leu Lys Glu Ala 
     690                695                700
Arg Gly Arg Gly Lys Lys Phe Thr Thr Asp Asp Ser Ile Cys Val Leu 
 705                710                715                720
Gly Ile Ser Lys Arg Asn Val Ile Phe Gln Pro Val Ala Glu Leu Lys 
                 725                730                735
Lys Gln Thr Asp Phe Glu His Arg Ile Pro Lys Glu Gln Trp Trp Leu 
             740                745                750
Lys Leu Arg Pro Leu Met Lys Ile Leu Ala Lys Tyr Lys Ala Ser Tyr 
         755                760                765
Asp Val Ser Asp Ser Gly Gln Leu Glu His Val Gln Pro Trp Ser Val 
     770                775                780



<210> 3072
<211> 3463
<212> DNA
<213> Rattus norvegicus
<308> L25605
<400> 3072

cggtgaggg  agccgggcg  gtggcagag  agagcagga  gaagcaacg  ccacagacg  60
atcgggacc  cgagtcgta  tcgggggat  cgcggggcg  aggcgggca  catgggcaa  120
cgcgggatg  aagagctca  cccgctggt  aacaagctg  aggacgcct  cagctccat  180
ggtcagagc  gccacctgg  cctgccgca  atcgccgtg  tgggcggcc  gagcgccgg  240
aagagttcg  tgctcgaga  cttcgtggg  cgggacttc  ttccacgag  atcaggaat  300
gtcacccgg  ggcctctca  tctgcagct  atcttttcc  aaacagaat  tgcggagtt  360
ttgcactgc  agtccaaaa  gtttacaga  tttgatgaa  tccggcagg  gatcgaagc  420
gagactgac  gggtcacag  caccaacaa  ggcatctcc  cggtgccca  caaccttcg  480
gtctattca  cacacgtgt  gaacttgac  ctcatcgac  tcccaggca  cactaaggt  540
ccagttggg  accagccac  agacatcga  taccagatc  aggacatga  cctgcagtt  600
atcagccgg  agagcagcc  cattcttgc  gtcacacct  ccaacatgg  cttggccaa  660
tcggatgcc  tcaagctgg  caaggaggt  gacccccaa  gcttgcgga  cattggtgt  720
atcaccaag  tagacctga  ggatgaagg  acagatgcc  gggatgtcc  ggagaacaa  780
ctcctgccc  tgagaagag  ctacatcgg  gtggttaac  gcagccaga  agacatcga  840
ggcagaaag  acatccggg  agctctggc  gctgagagg  aattcttcc  ctcccaccc  900
gcctaccgg  acatggctg  ccgcatggg  accccacac  tgcagaaaa  actgaacca  960
caactgacc  accacatcc  ggagtcact  ccaaccctg  gcagcaagc  gcagagcca  1020
ctgctgtcc  tggagaagg  agtggaaga  tacaagaat  tccggcctg  cgaccccac  1080
cgcaagacc  aagccctgc  gcagatggt  cagcagttt  gagtggact  tgagaagcg  1140
atcgaaggc  ctggagatc  agtcgacac  ctggagctg  ctgggggcg  ccgcatcaa  1200
cgcatcttc  acgagcgct  tccctttga  ctggtgaag  tggagtttg  cgagaaaga  1260
ctccgaaga  agatcagct  cgccattaa  aacatccac  gagtcagaa  tgggctctt  1320
acgccggat  tggcgttcg  ggccattgt  aaaaagcag  tggtcaagc  gaaagagcc  1380
tgtctgaaa  gcgtggacc  ggttatcca  gagctaatc  gtacagtta  gcaatgcac  1440
agcaagctc  gttcctacc  ccgccttcg  gaggagacc  aacgcattg  caccaccta  1500
atcagggag  gagaaggga  aaccaagga  cagatcctt  ttctgattg  cattgagca  1560
tcctacatc  acacaaacc  tgaagactt  attggattt  ccaatgccc  gcagaggag  1620
acgcagctg  acaagaaga  ggccatacc  aaccagggg  agatcttgg  gatccgcag  1680
ggctggttg  ccatcaaca  catcagctt  atgaaaggc  gttccaagg  gtactggtt  1740
gtgctgact  ctgagtcgt  gtcttggta  aaggatgaa  aggaaaaag  aaagaagta  1800
atgctgcca  tagacaacc  caaaatacg  gatgtggag  agggcttca  gtccaacaa  1860
catgtgttt  ccatcttca  cacagagca  aggaacgtc  acaaggacc  gcgacagat  1920
gaactggct  gtgactccc  ggaagatgt  gacagctgg  aggcttcgt  cctgcgagc  1980
ggggtctac  cagagaagg  ccaggcaga  aacgaggat  gagcacaag  gaacacctt  2040
tccatggac  cgcagctgg  gcggcaggt  gagaccatc  gcaacttgg  ggactccta  2100
gtggccatc  tcaacaagt  catccggga  ctcatgcca  agaccatca  gcacctcat  2160
atcaacaac  caaaggcct  catccacca  gagctgcta  cctacctgt  ctcatcagc  2220
gaccagagc  gcctcatgg  ggagtcagc  gagcaggct  agcggcggg  cgatatgct  2280
cgcatgtac  atgcactca  ggaagcgct  aacatcatt  gggacatca  caccagcac  2340
gtgtccacg  ctgtgcccc  acctgtcga  gatacttgg  tccagaaca  cagcagcca  2400
agccccact  cacagcgca  acctgtgtc  agtgtgcac  cgccgggcc  cccacccgc  2460
gtgcggggc  ccacaccgg  gcctcccct  attcctatg  ctgtggggg  cacatcctc  2520
ttctcggca  cccccatcc  atcccggcc  ggaccacag  atgtgtttg  caacaatga  2580
cccttctct  cgccacctc  gataccgtc  cggccagca  ggattcccc  tgggatccc  2640
ccaggagtg  ccagcagaa  agcgcccgc  gcgcccagc  ggcccacca  tatccgccc  2700
gccgagccg  ccctgctcg  ctaggctgc  ggggacagt  ttctggggg  gtcctcgtg  2760
acctacagt  gtctgggcc  tgctactgc  ccccatgct  ggaccaggc  ccccgtggg  2820
aagcctgcc  tctcctccc  agccctagt  cacatgata  ggagggaga  ggtgggaag  2880
aggcccaaa  aaacagaac  tgggggctt  gcactttgg  gcgaggggg  gctctggtt  2940
gcagaacag  aactgcacc  ttgggacca  ctggaaaga  aggtctagg  tagtggtgg  3000
gaactctac  tgggctcct  catactgta  gcctttgct  tttctgagg  acagaactg  3060
ccacctttc  ctaaggact  ctcaggagt  agccaggcc  aggaggtcc  gtgctggcc  3120
cccacctgg  tcaagttgt  tatatatat  tagcttctt  ggccacatt  accacacag  3180
ctgagccca  cccagtctc  acacccaga  gtgcctttg  gccttccag  cctggagtg  3240
ctcagctct  gcctgcctc  ctcctcagc  cctgttgtg  tttgggctg  aagaactct  3300
gagacatca  gacctcttg  cttccaacc  gatgtctcc  acagggtgg  ccctggtgc  3360
tctgtacag  ttctgctcc  aacgcttgg  ttgaccact  ttaagtgcc  gcctctgta  3420
atcctatta  taaactaaa  taaagggaa  ccctctcgt  gct  3463



<210> 3073
<211> 870
<212> PRT
<213> Rattus norvegicus
<308> P39052
<400> 3073

Met Gly Asn Arg Gly Met Glu Glu Leu Ile Pro Leu Val Asn Lys Leu 
  1               5                  10                  15
Gln Asp Ala Phe Ser Ser Ile Gly Gln Ser Cys His Leu Asp Leu Pro 
             20                  25                  30
Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
         35                  40                  45
Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
     50                  55                  60
Thr Arg Arg Pro Leu Ile Leu Gln Leu Ile Phe Ser Lys Thr Glu Tyr 
 65                  70                  75                  80
Ala Glu Phe Leu His Cys Lys Ser Lys Lys Phe Thr Asp Phe Asp Glu 
                 85                  90                  95
Val Arg Gln Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Thr Asn 
             100                105                110
Lys Gly Ile Ser Pro Val Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
         115                120                125
Val Leu Asn Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Lys Val Pro 
     130                135                140
Val Gly Asp Gln Pro Pro Asp Ile Glu Tyr Gln Ile Lys Asp Met Ile 
 145                150                155                160
Leu Gln Phe Ile Ser Arg Glu Ser Ser Leu Ile Leu Ala Val Thr Pro 
                 165                170                175
Ala Asn Met Asp Leu Ala Asn Ser Asp Ala Leu Lys Leu Ala Lys Glu 
             180                185                190
Val Asp Pro Gln Gly Leu Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
         195                200                205
Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
     210                215                220
Leu Pro Leu Arg Arg Gly Tyr Ile Gly Val Val Asn Arg Ser Gln Lys 
 225                230                235                240
Asp Ile Glu Gly Arg Lys Asp Ile Arg Ala Ala Leu Ala Ala Glu Arg 
                 245                250                255
Lys Phe Phe Leu Ser His Pro Ala Tyr Arg His Met Ala Asp Arg Met 
             260                265                270
Gly Thr Pro His Leu Gln Lys Thr Leu Asn Gln Gln Leu Thr Asn His 
         275                280                285
Ile Arg Glu Ser Leu Pro Thr Leu Arg Ser Lys Leu Gln Ser Gln Leu 
     290                295                300
Leu Ser Leu Glu Lys Glu Val Glu Glu Tyr Lys Asn Phe Arg Pro Asp 
 305                310                315                320
Asp Pro Thr Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                 325                330                335
Gly Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Val Asp 
             340                345                350
Thr Leu Glu Leu Ser Gly Gly Ala Arg Ile Asn Arg Ile Phe His Glu 
         355                360                365
Arg Phe Pro Phe Glu Leu Val Lys Met Glu Phe Asp Glu Lys Asp Leu 
     370                375                380
Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Val Arg Thr 
 385                390                395                400
Gly Leu Phe Thr Pro Asp Leu Ala Phe Glu Ala Ile Val Lys Lys Gln 
                 405                410                415
Val Val Lys Leu Lys Glu Pro Cys Leu Lys Cys Val Asp Leu Val Ile 
             420                425                430
Gln Glu Leu Ile Ser Thr Val Arg Gln Cys Thr Ser Lys Leu Ser Ser 
         435                440                445
Tyr Pro Arg Leu Arg Glu Glu Thr Glu Arg Ile Val Thr Thr Tyr Ile 
     450                455                460
Arg Glu Arg Glu Gly Arg Thr Lys Asp Gln Ile Leu Leu Leu Ile Asp 
 465                470                475                480
Ile Glu Gln Ser Tyr Ile Asn Thr Asn His Glu Asp Phe Ile Gly Phe 
                 485                490                495
Ala Asn Ala Gln Gln Arg Ser Thr Gln Leu Asn Lys Lys Arg Ala Ile 
             500                505                510
Pro Asn Gln Gly Glu Ile Leu Val Ile Arg Arg Gly Trp Leu Thr Ile 
         515                520                525
Asn Asn Ile Ser Leu Met Lys Gly Gly Ser Lys Glu Tyr Trp Phe Val 
     530                535                540
Leu Thr Ala Glu Ser Leu Ser Trp Tyr Lys Asp Glu Glu Glu Lys Glu 
 545                550                555                560
Lys Lys Tyr Met Leu Pro Leu Asp Asn Leu Lys Ile Arg Asp Val Glu 
                 565                570                575
Lys Gly Phe Met Ser Asn Lys His Val Phe Ala Ile Phe Asn Thr Glu 
             580                585                590
Gln Arg Asn Val Tyr Lys Asp Leu Arg Gln Ile Glu Leu Ala Cys Asp 
         595                600                605
Ser Gln Glu Asp Val Asp Ser Trp Lys Ala Ser Phe Leu Arg Ala Gly 
     610                615                620
Val Tyr Pro Glu Lys Asp Gln Ala Glu Asn Glu Asp Gly Ala Gln Glu 
 625                630                635                640
Asn Thr Phe Ser Met Asp Pro Gln Leu Glu Arg Gln Val Glu Thr Ile 
                 645                650                655
Arg Asn Leu Val Asp Ser Tyr Val Ala Ile Ile Asn Lys Ser Ile Arg 
             660                665                670
Asp Leu Met Pro Lys Thr Ile Met His Leu Met Ile Asn Asn Thr Lys 
         675                680                685
Ala Phe Ile His His Glu Leu Leu Ala Tyr Leu Tyr Ser Ser Ala Asp 
     690                695                700
Gln Ser Ser Leu Met Glu Glu Ser Ala Glu Gln Ala Gln Arg Arg Asp 
 705                710                715                720
Asp Met Leu Arg Met Tyr His Ala Leu Lys Glu Ala Leu Asn Ile Ile 
                 725                730                735
Gly Asp Ile Ser Thr Ser Thr Val Ser Thr Pro Val Pro Pro Pro Val 
             740                745                750
Asp Asp Thr Trp Leu Gln Asn Thr Ser Ser His Ser Pro Thr Pro Gln 
         755                760                765
Arg Arg Pro Val Ser Ser Val His Pro Pro Gly Arg Pro Pro Ala Val 
     770                775                780
Arg Gly Pro Thr Pro Gly Pro Pro Leu Ile Pro Met Pro Val Gly Ala 
 785                790                795                800
Thr Ser Ser Phe Ser Ala Pro Pro Ile Pro Ser Arg Pro Gly Pro Gln 
                 805                810                815
Asn Val Phe Ala Asn Asn Asp Pro Phe Ser Ala Pro Pro Gln Ile Pro 
             820                825                830
Ser Arg Pro Ala Arg Ile Pro Pro Gly Ile Pro Pro Gly Val Pro Ser 
         835                840                845
Arg Arg Ala Pro Ala Ala Pro Ser Arg Pro Thr Ile Ile Arg Pro Ala 
     850                855                860
Glu Pro Ser Leu Leu Asp 
 865                870



<210> 3074
<211> 3601
<212> DNA
<213> Homo sapiens
<308> NM_004945
<400> 3074

gaccgtgag  ccgagccgg  agcgggcgt  ttgccgagg  ccgggcggg  gggagcaac  60
gctacagac  ccgcggggc  aggtcgttg  gggtcggcg  cgggcgagg  gcgcagggc  120
ctcgggccg  gggccgccg  cgccatggg  aaccgcggg  tggaagagc  gatcccgct  180
gtcaacaaa  tgcaggacg  cttcagctc  atcggccag  gctgccacc  ggacctgcc  240
cagatcgct  tagtgggcg  ccagagcgc  ggcaagagc  cggtgctgg  gaacttcgt  300
ggccgggac  tccttcccc  cggttcagg  atcgtcacc  ggcggcctc  cattctgca  360
ctcatcttc  caaaaacag  acatgccga  tttttgcac  gcaagtcca  aaagtttac  420
gactttgat  aagtccggc  ggagattga  gcagagacc  acagggtca  ggggaccaa  480
aaaggcatc  ccccagtgc  catcaacct  cgagtctac  cgccacacg  gttgaactt  540
accctcatc  acctcccgg  tatcaccaa  gtgcctgtg  gcgaccagc  tccagacat  600
gagtaccga  tcaaggaca  gatcctgca  ttcatcagc  gggagagca  cctcattct  660
gctgtcacg  ccgccaaca  ggacctggc  aactccgac  ccctcaagc  ggccaagga  720
gtcgatccc  aaggcctac  gaccatcgg  gtcatcacc  agcttgacc  gatggacga  780
ggcaccgac  ccagggacg  cttggagaa  aagttgctc  cgttgagaa  aggctacat  840
ggcgtggtg  accgcagcc  gaaggatat  gagggcaag  aggacatcc  tgcagcact  900
gcagctgag  ggaagttct  cctctccca  ccggcctac  ggcacatgg  cgaccgcat  960
ggcacgcca  atctgcaga  gacgctgaa  cagcaactg  ccaaccaca  ccgggagtc  1020
ctgccggcc  tacgtagca  actacagag  cagctgctg  ccctggaga  ggaggtgga  1080
gagtacaag  tctttcggc  cgacgaccc  acccctaaa  ccaaagccc  gctgcagat  1140
gtccagcag  ttggggtgg  ttttgagaa  aggatcgag  gctcaggag  tcaggtgga  1200
actctggag  tctccgggg  cgcccgaat  aatcgcatc  tccacgagc  gttcccatt  1260
gagctggtg  agatggagt  tgacgagaa  gacttacga  gggagatca  ctatgccat  1320
aagaacatc  atggagtca  gaccgggct  ttcaccccg  acttggcat  cgaggccat  1380
gtgaaaaag  aggtcgtca  gctgaaaga  ccctgtctg  aatgtgtcg  cctggttat  1440
caggagcta  tcaatacag  taggcagtg  accagtaag  tcagttcct  cccccggtt  1500
cgagaggag  cagagcgaa  cgtcaccac  tacatccgg  aacgggagg  gagaacgaa  1560
gaccagatt  ttctgctga  cgacattga  cagtcctac  tcaacacga  ccatgagga  1620
ttcatcggg  ttgccaatg  ccagcagag  agcacgcag  tgaacaaga  gagagccat  1680
cccaatcag  tgatccgca  gggctggct  accatcaac  acatcagcc  gatgaaagg  1740
ggctccaag  agtactggt  tgtgctgac  gccgagtca  tgtcctggt  caaggatga  1800
gaggagaaa  agaagaagt  catgctgcc  ctggacaac  tcaagatcc  tgatgtgga  1860
aagggcttc  tgtccaaca  gcacgtctt  gccatcttc  acacggagc  gagaaacgt  1920
tacaaggac  tgcggcaga  cgagctggc  tgtgactcc  aggaagacg  ggacagctg  1980
aaggcctcg  tcctccgag  tggcgtcta  cccgagaag  accaggcag  aaacgagga  2040
ggggcccag  agaacacct  ctccatgga  ccccaactg  agcggcagg  ggagaccat  2100
cgcaacctg  tggactcat  cgtggccat  atcaacaag  ccatccgcg  cctcatgcc  2160
aagaccatc  tgcacctca  gatcaacaa  acgaaggcc  tcatccacc  cgagctgct  2220
gcctaccta  actcctcgg  agaccagag  agcctcatg  aggagtcgg  tgaccaggc  2280
cagcggcgg  acgacatgc  gcgcatgta  catgccctc  aggaggcgc  caacatcat  2340
ggtgacatc  gcaccagca  tgtgtccac  cctgtaccc  cgcctgtcg  tgacacctg  2400
ctccagagc  ccagcagcc  cagccccac  ccacagcgc  gaccggtgt  cagcataca  2460
ccccctggc  ggcccccag  agtgagggg  cccactcca  ggccccccc  gattcctgt  2520
cccgtgggg  cagcagcct  cttctcggc  cccccaatc  catcccggc  tggacccca  2580
agcgtgttt  ccaacagtg  cctcttccc  gccccgcct  agatcccat  tcggccagt  2640
cggatcccc  cagggattc  cccaggagt  cccagcaga  gaccccctg  tgcgcccag  2700
cggcccacc  ttatccgcc  agccgagcc  tccctgctc  actaggcct  gaggggggc  2760
tgctctcgg  ggggcctca  gcacccgcg  cgcaggagc  tcagtggtc  ggggccctc  2820
gccgcccct  tgctgggac  aggctccca  tgggcagcc  tggcctctt  gttaacgct  2880
gccccggtc  agggccggc  cctgtgcct  gctggacac  gcactgcgc  aaggggccc  2940
ggagctcca  gcagggggc  ctggggtgt  gcactttgg  ggatggagt  tcagggtgg  3000
agagggggg  ccagaaccc  tgacaccat  ctgaatgag  ggtccagcc  gggggggac  3060
ctaccaagg  cttcttggg  tgggaaagc  catgtaggg  aggccttct  taagtgcgg  3120
caccaaggg  gcctacatc  ccaggcctt  ctggggtgc  ggggtatat  aacttccca  3180
tagcaggag  tccccagcg  caagcctgg  ccagtgggc  cggtagtgc  cagctggca  3240
gcctgaggt  tacatagtc  ttcccggcc  tattaacca  acagcctga  cctggccca  3300
cctcggctg  cagaggtgc  tttgctagg  ccggagccg  tgcccggcc  tgcccttgc  3360
ctattcctc  cctcctcct  ctcctgggt  ccccagggt  gctgggctt  ggctatgtg  3420
gtggtggtg  cggggggtc  tgggggcct  tcagctccc  cccatgcct  cctgatggg  3480
gggcccagg  cggcctctc  ctgaggaga  ctcacccac  cctcgctca  tttgaccac  3540
gtaagtgcc  gcactctgt  ttctattaa  aaactaaaa  aaagggaag  gcgtgctgg  3600
g  3601



<210> 3075
<211> 870
<212> PRT
<213> Homo sapiens
<308> P50570
<400> 3075

Met Gly Asn Arg Gly Met Glu Glu Leu Ile Pro Leu Val Asn Lys Leu 
  1               5                  10                  15
Gln Asp Ala Phe Ser Ser Ile Gly Gln Ser Cys His Leu Asp Leu Pro 
             20                  25                  30
Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
         35                  40                  45
Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
     50                  55                  60
Thr Arg Arg Pro Leu Ile Leu Gln Leu Ile Phe Ser Lys Thr Glu His 
 65                  70                  75                  80
Ala Glu Phe Leu His Cys Lys Ser Lys Lys Phe Thr Asp Phe Asp Glu 
                 85                  90                  95
Val Arg Gln Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Thr Asn 
             100                105                110
Lys Gly Ile Ser Pro Val Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
         115                120                125
Val Leu Asn Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Lys Val Pro 
     130                135                140
Val Gly Asp Gln Pro Pro Asp Ile Glu Tyr Arg Val Lys Asp Met Ile 
 145                150                155                160
Leu Gln Phe Ile Ser Arg Glu Ser Ser Leu Ile Leu Ala Val Thr Pro 
                 165                170                175
Ala Asn Met Asp Leu Ala Asn Ser Asp Ala Leu Lys Leu Ala Lys Glu 
             180                185                190
Val Asp Pro Gln Gly Leu Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
         195                200                205
Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
     210                215                220
Leu Pro Leu Arg Arg Gly Tyr Ile Gly Val Val Asn Arg Ser Gln Lys 
 225                230                235                240
Asp Ile Glu Gly Lys Lys Asp Ile Arg Ala Ala Leu Ala Ala Glu Arg 
                 245                250                255
Lys Phe Phe Leu Ser His Pro Ala Tyr Arg His Met Ala Asp Arg Met 
             260                265                270
Gly Thr Pro His Leu Gln Lys Thr Leu Asn Gln Gln Leu Thr Asn His 
         275                280                285
Ile Arg Glu Ser Leu Pro Ala Leu Arg Ser Lys Leu Gln Ser Gln Leu 
     290                295                300
Leu Ser Leu Glu Lys Glu Val Glu Glu Tyr Lys Ile Phe Arg Pro Asp 
 305                310                315                320
Asp Pro Thr Pro Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                 325                330                335
Gly Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Val Asp 
             340                345                350
Thr Leu Glu Leu Ser Gly Gly Ala Arg Ile Asn Arg Ile Phe His Glu 
         355                360                365
Arg Phe Pro Phe Glu Leu Val Lys Met Glu Phe Asp Glu Lys Asp Leu 
     370                375                380
Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Val Arg Thr 
 385                390                395                400
Gly Leu Phe Thr Pro Asp Leu Ala Phe Glu Ala Ile Val Lys Lys Gln 
                 405                410                415
Val Val Lys Leu Lys Glu Pro Cys Leu Lys Cys Val Asp Leu Val Ile 
             420                425                430
Gln Glu Leu Ile Asn Thr Val Arg Gln Cys Thr Ser Lys Leu Ser Ser 
         435                440                445
Tyr Pro Arg Leu Arg Glu Glu Thr Glu Arg Ile Val Thr Thr Tyr Ile 
     450                455                460
Arg Glu Arg Glu Gly Arg Thr Lys Asp Gln Ile Leu Leu Leu Ile Asp 
 465                470                475                480
Ile Glu Gln Ser Tyr Ile Asn Thr Asn His Glu Asp Phe Ile Gly Phe 
                 485                490                495
Ala Asn Ala Gln Gln Arg Ser Thr Gln Leu Asn Lys Lys Arg Ala Ile 
             500                505                510
Pro Asn Gln Gly Glu Ile Leu Val Ile Arg Arg Gly Trp Leu Thr Ile 
         515                520                525
Asn Asn Ile Ser Leu Met Lys Gly Gly Ser Lys Glu Tyr Trp Phe Val 
     530                535                540
Leu Thr Ala Glu Ser Leu Ser Trp Tyr Lys Asp Glu Glu Glu Lys Glu 
 545                550                555                560
Lys Lys Tyr Met Leu Pro Leu Asp Asn Leu Lys Ile Arg Asp Val Glu 
                 565                570                575
Lys Gly Phe Met Ser Asn Lys His Val Phe Ala Ile Phe Asn Thr Glu 
             580                585                590
Gln Arg Asn Val Tyr Lys Asp Leu Arg Gln Ile Glu Leu Ala Cys Asp 
         595                600                605
Ser Gln Glu Asp Val Asp Ser Trp Lys Ala Ser Phe Leu Arg Ala Gly 
     610                615                620
Val Tyr Pro Glu Lys Asp Gln Ala Glu Asn Glu Asp Gly Ala Gln Glu 
 625                630                635                640
Asn Thr Phe Ser Met Asp Pro Gln Leu Glu Arg Gln Val Glu Thr Ile 
                 645                650                655
Arg Asn Leu Val Asp Ser Tyr Val Ala Ile Ile Asn Lys Ser Ile Arg 
             660                665                670
Asp Leu Met Pro Lys Thr Ile Met His Leu Met Ile Asn Asn Thr Lys 
         675                680                685
Ala Phe Ile His His Glu Leu Leu Ala Tyr Leu Tyr Ser Ser Ala Asp 
     690                695                700
Gln Ser Ser Leu Met Glu Glu Ser Ala Asp Gln Ala Gln Arg Arg Asp 
 705                710                715                720
Asp Met Leu Arg Met Tyr His Ala Leu Lys Glu Ala Leu Asn Ile Ile 
                 725                730                735
Gly Asp Ile Ser Thr Ser Thr Val Ser Thr Pro Val Pro Pro Pro Val 
             740                745                750
Asp Asp Thr Trp Leu Gln Ser Ala Ser Ser His Ser Pro Thr Pro Gln 
         755                760                765
Arg Arg Pro Val Ser Ser Ile His Pro Pro Gly Arg Pro Pro Ala Val 
     770                775                780
Arg Gly Pro Thr Pro Gly Pro Pro Leu Ile Pro Val Pro Val Gly Ala 
 785                790                795                800
Ala Ala Ser Phe Ser Ala Pro Pro Ile Pro Ser Arg Pro Gly Pro Gln 
                 805                810                815
Ser Val Phe Ala Asn Ser Asp Leu Phe Pro Ala Pro Pro Gln Ile Pro 
             820                825                830
Ser Arg Pro Val Arg Ile Pro Pro Gly Ile Pro Pro Gly Val Pro Ser 
         835                840                845
Arg Arg Pro Pro Ala Ala Pro Ser Arg Pro Thr Ile Ile Arg Pro Ala 
     850                855                860
Glu Pro Ser Leu Leu Asp 
 865                870



<210> 3076
<211> 719
<212> DNA
<213> Rattus norvegicus
<308> L25633
<400> 3076

gtgacttcc  ggcacagcc  ccctggctg  tgtcgctac  tccactacg  tctagctcg  60
ggaaccgtg  gctcggatc  agcgaagat  cagagttcg  tgaagcccg  gggctccgg  120
gttcttcag  tactggtct  cttccttct  ctatacagt  gcccaagca  ctgcagcga  180
ataaatgcc  acgatggtc  gggccaagt  ggatcagag  agctctgga  gttccaagg  240
ctcgttgcc  cagtcttcc  gtacttaca  cttctattc  accacattg  accccaagg  300
atgttctgg  ccgatgaca  agcctatga  ttaatgacc  aaaaggtgg  gcacctcag  360
agactccat  cccagtatc  atgccggaa  gaggggaag  tggtttctc  cattgcaac  420
actggggtg  ggggcaagc  agaggagaa  cttcgactc  tatcgcccc  aaagagtcc  480
gcagtcaag  tgaataggg  ccgatgctt  accaccaaa  taatcccaa  ggccaccaa  540
caagaggtc  cccatccct  caagggttt  tttgggcca  tccccactg  gggtctcaa  600
cttgttgct  actgagatc  cactgtata  gatcctttt  cccgggaac  tcctcactg  660
cctccaagg  gcaattctt  gatgactca  atataagta  ttaaagttg  ctttcatgc  719



<210> 3077
<211> 175
<212> PRT
<213> Rattus norvegicus
<308> P47940
<400> 3077

Met Gln Ser Ser Leu Lys Pro Ala Gly Ser Gly Val Leu Gln Leu Leu 
  1               5                  10                  15
Val Cys Phe Leu Leu Leu Tyr Ser Arg Pro Ser Ser Cys Ser Asp Ile 
             20                  25                  30
Asn Ala His Asp Gly Gln Gly Gln Val Gly Ser Glu Gln Leu Trp Thr 
         35                  40                  45
Phe Gln Gly Leu Val Ala Ser Val Phe Gln Tyr Leu Gln Leu Leu Phe 
     50                  55                  60
His His Ile Val Pro Gln Gly Met Phe Trp Thr Asp Asp Ile Ala Tyr 
 65                  70                  75                  80
Glu Leu Met Thr Lys Lys Val Glu His Leu Ser Arg Leu His Pro Gln 
                 85                  90                  95
Tyr Pro Cys Arg Lys Glu Gly Lys Val Val Ser Pro Ile Ala Thr Thr 
             100                105                110
Gly Val Arg Gly Lys Gln Glu Glu Lys Leu Arg Leu Leu Ser Pro Gln 
         115                120                125
Lys Ser Pro Ala Val Lys Val Asn Arg Asp Arg Cys Phe Thr Thr Lys 
     130                135                140
Val Ile Pro Lys Ala Thr Lys Gln Glu Val Thr His Pro Ser Lys Gly 
 145                150                155                160
Phe Phe Gly Pro Phe Pro Thr Val Gly Leu Asn Leu Val Ala Asp 
                 165                170                175



<210> 3078
<211> 3649
<212> DNA
<213> Homo sapiens
<308> NM_002846
<400> 3078

gcggcaagc  ccgcctcag  ccctctggc  ggctcccgc  agcgtcgct  cggctccgg  60
ccgggagcg  gcgcccgga  ctcggaaag  tgcggcgcc  gcggcggcc  gggggtctc  120
ggggatccg  gggtctccg  ctgctcctc  gcctcctgc  gctgagcag  cgcccgggg  180
gctgcagcg  cgttagtgc  cacggctgt  tatttgacc  caggctctg  tctcacctg  240
aagtctgta  tcaggatgg  ttgtttggg  agtgccagg  gggagtggg  caggcccgg  300
cccttttgc  agtcacctc  ccagttctc  aacgcttac  aggtgtgct  cgacaactc  360
tgtcccaag  attgtcctg  cacgatgac  tcacccagt  tgtgatctc  caggagatg  420
agcgcatcc  caggcttcg  cccccagag  cccgtccaa  ggacaggtc  ggcttggca  480
ccaagagac  tggtcctgc  ggagagctg  ttttacagg  catccccac  ggctccgcc  540
ctgctgccc  gcatcggct  ccacaacca  cagtgggca  aggtggagc  ggggccagc  600
cctctctgt  ccctctgca  gctgagctg  tcccgcctc  cttggagca  ctgctgctg  660
ccccacagc  tccccaccc  tcactgagt  acgaacctg  cttgctgca  ccctacctg  720
tccaccagt  tggctcccg  gatggctcc  gggtctcag  gggctcccc  gggatggtc  780
gtgtcggcc  cctgcccaa  gctgaagcc  ctgccctct  cagcagaac  gcctccaag  840
gcatatttg  ggaccaccc  ggccactcc  acggggacc  tccagggcc  tcacctgcc  900
agctttttc  agactctgg  ctgctctat  tggcccagg  gttgccagc  cccagcagg  960
ccagggtgc  aaggctgcc  gagcaaggg  gcagcagcc  ggcagagga  tccccagag  1020
gctatgaga  ggaaggact  ggggatcgt  gagagaagc  tgcttcccc  gctgtgcag  1080
cagatgcgg  tctgcagag  ctggccgct  tgctggcgg  ctatggggt  gagctgcgt  1140
agctgaccc  tgagcagct  tccacactc  tgaccctgc  gcagctact  cccaagggt  1200
caggaagaa  tccgggagg  gttgtaaat  ttggagctg  tatcaagaa  acaatggag  1260
ggccggtgg  gggcagaga  acagcagag  ttccagccc  cacatcccc  atgcctgga  1320
accccactg  cagccctac  tccagtgaa  tccagcagg  gccaagccc  gtctcctct  1380
agcctccca  agctgccag  ccccctgtg  cacctgtcc  gctagagaa  aaaagccca  1440
tgggccaga  ccagcccac  gtggcagga  agccctcag  ccgcccagc  gcagaggaa  1500
atggctaca  cgtcactga  cagaagccc  tgagcctgg  tgcaggagt  aagctgctg  1560
agatcctgg  tgagcatgt  cacatgtcc  caggcagct  catcaacat  agtgtggtg  1620
gaccagccc  caccttccg  atccggcac  atgagcaga  cctgtcttt  gctgatgtg  1680
cccaacaag  agggctggt  aagtctgaa  tggaagcac  gacagggct  caaatcttg  1740
agacaggag  gggacagag  gaggaggca  ctgcagtcc  tccccaaac  gcgcacagc  1800
cctcaccca  gcgctcagt  ctgctcact  tggtggccc  ggcaggtgt  gctgggctg  1860
tggtggctc  ggctgtggc  ctgtgtgtg  ggcagcatg  gcggcagca  gacaaggag  1920
gcctggcag  cctggggcc  gagggggcc  atggtgaca  tacctttga  taccaggac  1980
tgtgccgcc  gcacatggc  acgaagtcc  tgttcaacc  ggcagaggg  ccaccggag  2040
cttcacggg  gagcagtgt  tcctcccag  tcagcgacg  agcccaggc  agccccagc  2100
cccacagca  caccccgtc  tggtgcgag  agccggccc  agccaacat  gacatctcc  2160
cgggacaca  gattctggc  tacatggag  atcacctgc  gaaccggga  cgccttgcc  2220
aggagtggc  ggccctctg  gcctaccaa  cagagccaa  cacctgtgc  accgcgcag  2280
gggagggca  catcaaaaa  aaccggcat  ctgacttcc  gccctatga  catgcccgc  2340
taaaactga  ggtggagag  agcccttct  ggagcgatt  catcaacgc  agccccatt  2400
ttgagcatg  ccctcggat  ccagcctac  tagccacgc  gggcccgct  tcccatacc  2460
tcgcagact  ctggcagat  gtgtgggag  gcggctgca  cgtcatcgt  atgctgacc  2520
cgctggtgg  ggatggtgt  aagcagtgt  accgctact  gccagatga  ggtgcctcc  2580
tctaccacg  atatgaggt  aacctggtg  cggagcaca  ctggtgcga  gactttctg  2640
tgcggagct  ctacctgaa  aacgtgcag  cccaggaga  gcgcacgct  acgcagttc  2700
acttcctca  ctggccggc  gagggcaca  cggcctcca  gcggcccct  ctggacttc  2760
gcaggaagg  gaacaagtg  taccggggc  gctcctgcc  catcatcgt  cactgcagt  2820
atggtgcgg  gaggaccgg  acctacatc  tcatcgaca  ggtcctgaa  cgcatggca  2880
aaggagtga  ggagattga  atcgctgcc  ccctggagc  tgtccgtga  cagcggcct  2940
gccttgtcc  ctctaagga  cagtttgaa  ttgccctga  agccgtggc  gaggaagtg  3000
atgccatcc  caaggccct  ccccagtga  accctgggg  cccttggcg  gcagcccag  3060
ctctgtccc  ctttgcctg  gtgagcatc  ctgtgtacc  actcctcac  gccccacca  3120
ccacctctt  ggcatgctc  gcccttcct  gaagagtca  gaagggaaa  ccagaaggg  3180
cacgcctgc  cagcctcgc  tgccagagc  tggggcatc  cagagccca  ggcatccca  3240
gggggtgct  cagccagga  gagaggaaa  gacatgggt  gcaattcta  ccagagcct  3300
ctcctgcct  cattccctg  cctggctct  ctgtagctc  cctggggtt  tgggagttc  3360
ctgaacatc  gtgtgtgtc  ccctatgct  cagtatgga  gaatggggt  gagggtcgc  3420
acacccggc  ccccctgct  ctcagcccc  ggcctgcct  tgactcaca  ttgggcgct  3480
tgccctccc  ggcctcacg  ccagcctcc  cccaccacc  tcccaccat  cgctgctca  3540
cctctctcc  tctggcgca  gagaacatt  ctagaaaaa  ctacttttg  accagtgtg  3600
ataaagtta  tgtgttgtc  gtgcagctg  aaaaaaaaa  aaaaaaaaa  3649



<210> 3079
<211> 979
<212> PRT
<213> Homo sapiens
<308> Q16849
<400> 3079

Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu 
  1               5                  10                  15
Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys 
             20                  25                  30
Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser 
         35                  40                  45
His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val 
     50                  55                  60
Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu 
 65                  70                  75                  80
Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser 
                 85                  90                  95
Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg 
             100                105                110
Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly 
         115                120                125
Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp 
     130                135                140
Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro 
 145                150                155                160
Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu 
                 165                170                175
Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro 
             180                185                190
Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro 
         195                200                205
Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu 
     210                215                220
Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala 
 225                230                235                240
Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His 
                 245                250                255
Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu 
             260                265                270
Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro 
         275                280                285
Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg 
     290                295                300
Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg 
 305                310                315                320
Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln 
                 325                330                335
Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu 
             340                345                350
Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro 
         355                360                365
Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp 
     370                375                380
Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu 
 385                390                395                400
Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro 
                 405                410                415
Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro 
             420                425                430
Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys 
         435                440                445
Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala 
     450                455                460
Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro 
 465                470                475                480
Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His 
                 485                490                495
Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro 
             500                505                510
Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala 
         515                520                525
Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln 
     530                535                540
Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala 
 545                550                555                560
Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser 
                 565                570                575
Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val 
             580                585                590
Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp 
         595                600                605
Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr 
     610                615                620
Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser 
 625                630                635                640
Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser 
                 645                650                655
Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His 
             660                665                670
Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp 
         675                680                685
Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg 
     690                695                700
Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln 
 705                710                715                720
Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys 
                 725                730                735
Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys 
             740                745                750
Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser 
         755                760                765
Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln 
     770                775                780
Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu 
 785                790                795                800
Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly 
                 805                810                815
Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr 
             820                825                830
His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp 
         835                840                845
Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr 
     850                855                860
Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr 
 865                870                875                880
Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys 
                 885                890                895
Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly 
             900                905                910
Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg 
         915                920                925
Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His 
     930                935                940
Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu 
 945                950                955                960
Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala 
                 965                970                975
Leu Pro Gln 
             980



<210> 3080
<211> 719
<212> DNA
<213> Rattus norvegicus
<308> L25633
<400> 3080

gtgacttcc  ggcacagcc  ccctggctg  tgtcgctac  tccactacg  tctagctcg  60
ggaaccgtg  gctcggatc  agcgaagat  cagagttcg  tgaagcccg  gggctccgg  120
gttcttcag  tactggtct  cttccttct  ctatacagt  gcccaagca  ctgcagcga  180
ataaatgcc  acgatggtc  gggccaagt  ggatcagag  agctctgga  gttccaagg  240
ctcgttgcc  cagtcttcc  gtacttaca  cttctattc  accacattg  accccaagg  300
atgttctgg  ccgatgaca  agcctatga  ttaatgacc  aaaaggtgg  gcacctcag  360
agactccat  cccagtatc  atgccggaa  gaggggaag  tggtttctc  cattgcaac  420
actggggtg  ggggcaagc  agaggagaa  cttcgactc  tatcgcccc  aaagagtcc  480
gcagtcaag  tgaataggg  ccgatgctt  accaccaaa  taatcccaa  ggccaccaa  540
caagaggtc  cccatccct  caagggttt  tttgggcca  tccccactg  gggtctcaa  600
cttgttgct  actgagatc  cactgtata  gatcctttt  cccgggaac  tcctcactg  660
cctccaagg  gcaattctt  gatgactca  atataagta  ttaaagttg  ctttcatgc  719



<210> 3081
<211> 175
<212> PRT
<213> Rattus norvegicus
<308> P47940
<400> 3081

Met Gln Ser Ser Leu Lys Pro Ala Gly Ser Gly Val Leu Gln Leu Leu 
  1               5                  10                  15
Val Cys Phe Leu Leu Leu Tyr Ser Arg Pro Ser Ser Cys Ser Asp Ile 
             20                  25                  30
Asn Ala His Asp Gly Gln Gly Gln Val Gly Ser Glu Gln Leu Trp Thr 
         35                  40                  45
Phe Gln Gly Leu Val Ala Ser Val Phe Gln Tyr Leu Gln Leu Leu Phe 
     50                  55                  60
His His Ile Val Pro Gln Gly Met Phe Trp Thr Asp Asp Ile Ala Tyr 
 65                  70                  75                  80
Glu Leu Met Thr Lys Lys Val Glu His Leu Ser Arg Leu His Pro Gln 
                 85                  90                  95
Tyr Pro Cys Arg Lys Glu Gly Lys Val Val Ser Pro Ile Ala Thr Thr 
             100                105                110
Gly Val Arg Gly Lys Gln Glu Glu Lys Leu Arg Leu Leu Ser Pro Gln 
         115                120                125
Lys Ser Pro Ala Val Lys Val Asn Arg Asp Arg Cys Phe Thr Thr Lys 
     130                135                140
Val Ile Pro Lys Ala Thr Lys Gln Glu Val Thr His Pro Ser Lys Gly 
 145                150                155                160
Phe Phe Gly Pro Phe Pro Thr Val Gly Leu Asn Leu Val Ala Asp 
                 165                170                175



<210> 3082
<211> 3649
<212> DNA
<213> Homo sapiens
<308> NM_002846
<400> 3082

gcggcaagc  ccgcctcag  ccctctggc  ggctcccgc  agcgtcgct  cggctccgg  60
ccgggagcg  gcgcccgga  ctcggaaag  tgcggcgcc  gcggcggcc  gggggtctc  120
ggggatccg  gggtctccg  ctgctcctc  gcctcctgc  gctgagcag  cgcccgggg  180
gctgcagcg  cgttagtgc  cacggctgt  tatttgacc  caggctctg  tctcacctg  240
aagtctgta  tcaggatgg  ttgtttggg  agtgccagg  gggagtggg  caggcccgg  300
cccttttgc  agtcacctc  ccagttctc  aacgcttac  aggtgtgct  cgacaactc  360
tgtcccaag  attgtcctg  cacgatgac  tcacccagt  tgtgatctc  caggagatg  420
agcgcatcc  caggcttcg  cccccagag  cccgtccaa  ggacaggtc  ggcttggca  480
ccaagagac  tggtcctgc  ggagagctg  ttttacagg  catccccac  ggctccgcc  540
ctgctgccc  gcatcggct  ccacaacca  cagtgggca  aggtggagc  ggggccagc  600
cctctctgt  ccctctgca  gctgagctg  tcccgcctc  cttggagca  ctgctgctg  660
ccccacagc  tccccaccc  tcactgagt  acgaacctg  cttgctgca  ccctacctg  720
tccaccagt  tggctcccg  gatggctcc  gggtctcag  gggctcccc  gggatggtc  780
gtgtcggcc  cctgcccaa  gctgaagcc  ctgccctct  cagcagaac  gcctccaag  840
gcatatttg  ggaccaccc  ggccactcc  acggggacc  tccagggcc  tcacctgcc  900
agctttttc  agactctgg  ctgctctat  tggcccagg  gttgccagc  cccagcagg  960
ccagggtgc  aaggctgcc  gagcaaggg  gcagcagcc  ggcagagga  tccccagag  1020
gctatgaga  ggaaggact  ggggatcgt  gagagaagc  tgcttcccc  gctgtgcag  1080
cagatgcgg  tctgcagag  ctggccgct  tgctggcgg  ctatggggt  gagctgcgt  1140
agctgaccc  tgagcagct  tccacactc  tgaccctgc  gcagctact  cccaagggt  1200
caggaagaa  tccgggagg  gttgtaaat  ttggagctg  tatcaagaa  acaatggag  1260
ggccggtgg  gggcagaga  acagcagag  ttccagccc  cacatcccc  atgcctgga  1320
accccactg  cagccctac  tccagtgaa  tccagcagg  gccaagccc  gtctcctct  1380
agcctccca  agctgccag  ccccctgtg  cacctgtcc  gctagagaa  aaaagccca  1440
tgggccaga  ccagcccac  gtggcagga  agccctcag  ccgcccagc  gcagaggaa  1500
atggctaca  cgtcactga  cagaagccc  tgagcctgg  tgcaggagt  aagctgctg  1560
agatcctgg  tgagcatgt  cacatgtcc  caggcagct  catcaacat  agtgtggtg  1620
gaccagccc  caccttccg  atccggcac  atgagcaga  cctgtcttt  gctgatgtg  1680
cccaacaag  agggctggt  aagtctgaa  tggaagcac  gacagggct  caaatcttg  1740
agacaggag  gggacagag  gaggaggca  ctgcagtcc  tccccaaac  gcgcacagc  1800
cctcaccca  gcgctcagt  ctgctcact  tggtggccc  ggcaggtgt  gctgggctg  1860
tggtggctc  ggctgtggc  ctgtgtgtg  ggcagcatg  gcggcagca  gacaaggag  1920
gcctggcag  cctggggcc  gagggggcc  atggtgaca  tacctttga  taccaggac  1980
tgtgccgcc  gcacatggc  acgaagtcc  tgttcaacc  ggcagaggg  ccaccggag  2040
cttcacggg  gagcagtgt  tcctcccag  tcagcgacg  agcccaggc  agccccagc  2100
cccacagca  caccccgtc  tggtgcgag  agccggccc  agccaacat  gacatctcc  2160
cgggacaca  gattctggc  tacatggag  atcacctgc  gaaccggga  cgccttgcc  2220
aggagtggc  ggccctctg  gcctaccaa  cagagccaa  cacctgtgc  accgcgcag  2280
gggagggca  catcaaaaa  aaccggcat  ctgacttcc  gccctatga  catgcccgc  2340
taaaactga  ggtggagag  agcccttct  ggagcgatt  catcaacgc  agccccatt  2400
ttgagcatg  ccctcggat  ccagcctac  tagccacgc  gggcccgct  tcccatacc  2460
tcgcagact  ctggcagat  gtgtgggag  gcggctgca  cgtcatcgt  atgctgacc  2520
cgctggtgg  ggatggtgt  aagcagtgt  accgctact  gccagatga  ggtgcctcc  2580
tctaccacg  atatgaggt  aacctggtg  cggagcaca  ctggtgcga  gactttctg  2640
tgcggagct  ctacctgaa  aacgtgcag  cccaggaga  gcgcacgct  acgcagttc  2700
acttcctca  ctggccggc  gagggcaca  cggcctcca  gcggcccct  ctggacttc  2760
gcaggaagg  gaacaagtg  taccggggc  gctcctgcc  catcatcgt  cactgcagt  2820
atggtgcgg  gaggaccgg  acctacatc  tcatcgaca  ggtcctgaa  cgcatggca  2880
aaggagtga  ggagattga  atcgctgcc  ccctggagc  tgtccgtga  cagcggcct  2940
gccttgtcc  ctctaagga  cagtttgaa  ttgccctga  agccgtggc  gaggaagtg  3000
atgccatcc  caaggccct  ccccagtga  accctgggg  cccttggcg  gcagcccag  3060
ctctgtccc  ctttgcctg  gtgagcatc  ctgtgtacc  actcctcac  gccccacca  3120
ccacctctt  ggcatgctc  gcccttcct  gaagagtca  gaagggaaa  ccagaaggg  3180
cacgcctgc  cagcctcgc  tgccagagc  tggggcatc  cagagccca  ggcatccca  3240
gggggtgct  cagccagga  gagaggaaa  gacatgggt  gcaattcta  ccagagcct  3300
ctcctgcct  cattccctg  cctggctct  ctgtagctc  cctggggtt  tgggagttc  3360
ctgaacatc  gtgtgtgtc  ccctatgct  cagtatgga  gaatggggt  gagggtcgc  3420
acacccggc  ccccctgct  ctcagcccc  ggcctgcct  tgactcaca  ttgggcgct  3480
tgccctccc  ggcctcacg  ccagcctcc  cccaccacc  tcccaccat  cgctgctca  3540
cctctctcc  tctggcgca  gagaacatt  ctagaaaaa  ctacttttg  accagtgtg  3600
ataaagtta  tgtgttgtc  gtgcagctg  aaaaaaaaa  aaaaaaaaa  3649



<210> 3083
<211> 979
<212> PRT
<213> Homo sapiens
<308> Q16849
<400> 3083

Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu 
  1               5                  10                  15
Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys 
             20                  25                  30
Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser 
         35                  40                  45
His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val 
     50                  55                  60
Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu 
 65                  70                  75                  80
Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser 
                 85                  90                  95
Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg 
             100                105                110
Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly 
         115                120                125
Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp 
     130                135                140
Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro 
 145                150                155                160
Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu 
                 165                170                175
Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro 
             180                185                190
Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro 
         195                200                205
Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu 
     210                215                220
Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala 
 225                230                235                240
Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His 
                 245                250                255
Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu 
             260                265                270
Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro 
         275                280                285
Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg 
     290                295                300
Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg 
 305                310                315                320
Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln 
                 325                330                335
Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu 
             340                345                350
Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro 
         355                360                365
Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp 
     370                375                380
Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu 
 385                390                395                400
Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro 
                 405                410                415
Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro 
             420                425                430
Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys 
         435                440                445
Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala 
     450                455                460
Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro 
 465                470                475                480
Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His 
                 485                490                495
Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro 
             500                505                510
Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala 
         515                520                525
Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln 
     530                535                540
Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala 
 545                550                555                560
Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser 
                 565                570                575
Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val 
             580                585                590
Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp 
         595                600                605
Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr 
     610                615                620
Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser 
 625                630                635                640
Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser 
                 645                650                655
Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His 
             660                665                670
Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp 
         675                680                685
Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg 
     690                695                700
Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln 
 705                710                715                720
Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys 
                 725                730                735
Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys 
             740                745                750
Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser 
         755                760                765
Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln 
     770                775                780
Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu 
 785                790                795                800
Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly 
                 805                810                815
Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr 
             820                825                830
His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp 
         835                840                845
Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr 
     850                855                860
Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr 
 865                870                875                880
Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys 
                 885                890                895
Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly 
             900                905                910
Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg 
         915                920                925
Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His 
     930                935                940
Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu 
 945                950                955                960
Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala 
                 965                970                975
Leu Pro Gln 
             980



<210> 3084
<211> 719
<212> DNA
<213> Rattus norvegicus
<308> L25633
<400> 3084

gtgacttcc  ggcacagcc  ccctggctg  tgtcgctac  tccactacg  tctagctcg  60
ggaaccgtg  gctcggatc  agcgaagat  cagagttcg  tgaagcccg  gggctccgg  120
gttcttcag  tactggtct  cttccttct  ctatacagt  gcccaagca  ctgcagcga  180
ataaatgcc  acgatggtc  gggccaagt  ggatcagag  agctctgga  gttccaagg  240
ctcgttgcc  cagtcttcc  gtacttaca  cttctattc  accacattg  accccaagg  300
atgttctgg  ccgatgaca  agcctatga  ttaatgacc  aaaaggtgg  gcacctcag  360
agactccat  cccagtatc  atgccggaa  gaggggaag  tggtttctc  cattgcaac  420
actggggtg  ggggcaagc  agaggagaa  cttcgactc  tatcgcccc  aaagagtcc  480
gcagtcaag  tgaataggg  ccgatgctt  accaccaaa  taatcccaa  ggccaccaa  540
caagaggtc  cccatccct  caagggttt  tttgggcca  tccccactg  gggtctcaa  600
cttgttgct  actgagatc  cactgtata  gatcctttt  cccgggaac  tcctcactg  660
cctccaagg  gcaattctt  gatgactca  atataagta  ttaaagttg  ctttcatgc  719



<210> 3085
<211> 175
<212> PRT
<213> Rattus norvegicus
<308> P47940
<400> 3085

Met Gln Ser Ser Leu Lys Pro Ala Gly Ser Gly Val Leu Gln Leu Leu 
  1               5                  10                  15
Val Cys Phe Leu Leu Leu Tyr Ser Arg Pro Ser Ser Cys Ser Asp Ile 
             20                  25                  30
Asn Ala His Asp Gly Gln Gly Gln Val Gly Ser Glu Gln Leu Trp Thr 
         35                  40                  45
Phe Gln Gly Leu Val Ala Ser Val Phe Gln Tyr Leu Gln Leu Leu Phe 
     50                  55                  60
His His Ile Val Pro Gln Gly Met Phe Trp Thr Asp Asp Ile Ala Tyr 
 65                  70                  75                  80
Glu Leu Met Thr Lys Lys Val Glu His Leu Ser Arg Leu His Pro Gln 
                 85                  90                  95
Tyr Pro Cys Arg Lys Glu Gly Lys Val Val Ser Pro Ile Ala Thr Thr 
             100                105                110
Gly Val Arg Gly Lys Gln Glu Glu Lys Leu Arg Leu Leu Ser Pro Gln 
         115                120                125
Lys Ser Pro Ala Val Lys Val Asn Arg Asp Arg Cys Phe Thr Thr Lys 
     130                135                140
Val Ile Pro Lys Ala Thr Lys Gln Glu Val Thr His Pro Ser Lys Gly 
 145                150                155                160
Phe Phe Gly Pro Phe Pro Thr Val Gly Leu Asn Leu Val Ala Asp 
                 165                170                175



<210> 3086
<211> 3649
<212> DNA
<213> Homo sapiens
<308> NM_002846
<400> 3086

gcggcaagc  ccgcctcag  ccctctggc  ggctcccgc  agcgtcgct  cggctccgg  60
ccgggagcg  gcgcccgga  ctcggaaag  tgcggcgcc  gcggcggcc  gggggtctc  120
ggggatccg  gggtctccg  ctgctcctc  gcctcctgc  gctgagcag  cgcccgggg  180
gctgcagcg  cgttagtgc  cacggctgt  tatttgacc  caggctctg  tctcacctg  240
aagtctgta  tcaggatgg  ttgtttggg  agtgccagg  gggagtggg  caggcccgg  300
cccttttgc  agtcacctc  ccagttctc  aacgcttac  aggtgtgct  cgacaactc  360
tgtcccaag  attgtcctg  cacgatgac  tcacccagt  tgtgatctc  caggagatg  420
agcgcatcc  caggcttcg  cccccagag  cccgtccaa  ggacaggtc  ggcttggca  480
ccaagagac  tggtcctgc  ggagagctg  ttttacagg  catccccac  ggctccgcc  540
ctgctgccc  gcatcggct  ccacaacca  cagtgggca  aggtggagc  ggggccagc  600
cctctctgt  ccctctgca  gctgagctg  tcccgcctc  cttggagca  ctgctgctg  660
ccccacagc  tccccaccc  tcactgagt  acgaacctg  cttgctgca  ccctacctg  720
tccaccagt  tggctcccg  gatggctcc  gggtctcag  gggctcccc  gggatggtc  780
gtgtcggcc  cctgcccaa  gctgaagcc  ctgccctct  cagcagaac  gcctccaag  840
gcatatttg  ggaccaccc  ggccactcc  acggggacc  tccagggcc  tcacctgcc  900
agctttttc  agactctgg  ctgctctat  tggcccagg  gttgccagc  cccagcagg  960
ccagggtgc  aaggctgcc  gagcaaggg  gcagcagcc  ggcagagga  tccccagag  1020
gctatgaga  ggaaggact  ggggatcgt  gagagaagc  tgcttcccc  gctgtgcag  1080
cagatgcgg  tctgcagag  ctggccgct  tgctggcgg  ctatggggt  gagctgcgt  1140
agctgaccc  tgagcagct  tccacactc  tgaccctgc  gcagctact  cccaagggt  1200
caggaagaa  tccgggagg  gttgtaaat  ttggagctg  tatcaagaa  acaatggag  1260
ggccggtgg  gggcagaga  acagcagag  ttccagccc  cacatcccc  atgcctgga  1320
accccactg  cagccctac  tccagtgaa  tccagcagg  gccaagccc  gtctcctct  1380
agcctccca  agctgccag  ccccctgtg  cacctgtcc  gctagagaa  aaaagccca  1440
tgggccaga  ccagcccac  gtggcagga  agccctcag  ccgcccagc  gcagaggaa  1500
atggctaca  cgtcactga  cagaagccc  tgagcctgg  tgcaggagt  aagctgctg  1560
agatcctgg  tgagcatgt  cacatgtcc  caggcagct  catcaacat  agtgtggtg  1620
gaccagccc  caccttccg  atccggcac  atgagcaga  cctgtcttt  gctgatgtg  1680
cccaacaag  agggctggt  aagtctgaa  tggaagcac  gacagggct  caaatcttg  1740
agacaggag  gggacagag  gaggaggca  ctgcagtcc  tccccaaac  gcgcacagc  1800
cctcaccca  gcgctcagt  ctgctcact  tggtggccc  ggcaggtgt  gctgggctg  1860
tggtggctc  ggctgtggc  ctgtgtgtg  ggcagcatg  gcggcagca  gacaaggag  1920
gcctggcag  cctggggcc  gagggggcc  atggtgaca  tacctttga  taccaggac  1980
tgtgccgcc  gcacatggc  acgaagtcc  tgttcaacc  ggcagaggg  ccaccggag  2040
cttcacggg  gagcagtgt  tcctcccag  tcagcgacg  agcccaggc  agccccagc  2100
cccacagca  caccccgtc  tggtgcgag  agccggccc  agccaacat  gacatctcc  2160
cgggacaca  gattctggc  tacatggag  atcacctgc  gaaccggga  cgccttgcc  2220
aggagtggc  ggccctctg  gcctaccaa  cagagccaa  cacctgtgc  accgcgcag  2280
gggagggca  catcaaaaa  aaccggcat  ctgacttcc  gccctatga  catgcccgc  2340
taaaactga  ggtggagag  agcccttct  ggagcgatt  catcaacgc  agccccatt  2400
ttgagcatg  ccctcggat  ccagcctac  tagccacgc  gggcccgct  tcccatacc  2460
tcgcagact  ctggcagat  gtgtgggag  gcggctgca  cgtcatcgt  atgctgacc  2520
cgctggtgg  ggatggtgt  aagcagtgt  accgctact  gccagatga  ggtgcctcc  2580
tctaccacg  atatgaggt  aacctggtg  cggagcaca  ctggtgcga  gactttctg  2640
tgcggagct  ctacctgaa  aacgtgcag  cccaggaga  gcgcacgct  acgcagttc  2700
acttcctca  ctggccggc  gagggcaca  cggcctcca  gcggcccct  ctggacttc  2760
gcaggaagg  gaacaagtg  taccggggc  gctcctgcc  catcatcgt  cactgcagt  2820
atggtgcgg  gaggaccgg  acctacatc  tcatcgaca  ggtcctgaa  cgcatggca  2880
aaggagtga  ggagattga  atcgctgcc  ccctggagc  tgtccgtga  cagcggcct  2940
gccttgtcc  ctctaagga  cagtttgaa  ttgccctga  agccgtggc  gaggaagtg  3000
atgccatcc  caaggccct  ccccagtga  accctgggg  cccttggcg  gcagcccag  3060
ctctgtccc  ctttgcctg  gtgagcatc  ctgtgtacc  actcctcac  gccccacca  3120
ccacctctt  ggcatgctc  gcccttcct  gaagagtca  gaagggaaa  ccagaaggg  3180
cacgcctgc  cagcctcgc  tgccagagc  tggggcatc  cagagccca  ggcatccca  3240
gggggtgct  cagccagga  gagaggaaa  gacatgggt  gcaattcta  ccagagcct  3300
ctcctgcct  cattccctg  cctggctct  ctgtagctc  cctggggtt  tgggagttc  3360
ctgaacatc  gtgtgtgtc  ccctatgct  cagtatgga  gaatggggt  gagggtcgc  3420
acacccggc  ccccctgct  ctcagcccc  ggcctgcct  tgactcaca  ttgggcgct  3480
tgccctccc  ggcctcacg  ccagcctcc  cccaccacc  tcccaccat  cgctgctca  3540
cctctctcc  tctggcgca  gagaacatt  ctagaaaaa  ctacttttg  accagtgtg  3600
ataaagtta  tgtgttgtc  gtgcagctg  aaaaaaaaa  aaaaaaaaa  3649



<210> 3087
<211> 979
<212> PRT
<213> Homo sapiens
<308> Q16849
<400> 3087

Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu 
  1               5                  10                  15
Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys 
             20                  25                  30
Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser 
         35                  40                  45
His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val 
     50                  55                  60
Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu 
 65                  70                  75                  80
Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser 
                 85                  90                  95
Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg 
             100                105                110
Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly 
         115                120                125
Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp 
     130                135                140
Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro 
 145                150                155                160
Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu 
                 165                170                175
Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro 
             180                185                190
Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro 
         195                200                205
Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu 
     210                215                220
Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala 
 225                230                235                240
Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His 
                 245                250                255
Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu 
             260                265                270
Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro 
         275                280                285
Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg 
     290                295                300
Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg 
 305                310                315                320
Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln 
                 325                330                335
Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu 
             340                345                350
Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro 
         355                360                365
Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp 
     370                375                380
Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu 
 385                390                395                400
Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro 
                 405                410                415
Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro 
             420                425                430
Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys 
         435                440                445
Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala 
     450                455                460
Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro 
 465                470                475                480
Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His 
                 485                490                495
Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro 
             500                505                510
Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala 
         515                520                525
Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln 
     530                535                540
Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala 
 545                550                555                560
Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser 
                 565                570                575
Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val 
             580                585                590
Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp 
         595                600                605
Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr 
     610                615                620
Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser 
 625                630                635                640
Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser 
                 645                650                655
Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His 
             660                665                670
Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp 
         675                680                685
Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg 
     690                695                700
Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln 
 705                710                715                720
Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys 
                 725                730                735
Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys 
             740                745                750
Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser 
         755                760                765
Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln 
     770                775                780
Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu 
 785                790                795                800
Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly 
                 805                810                815
Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr 
             820                825                830
His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp 
         835                840                845
Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr 
     850                855                860
Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr 
 865                870                875                880
Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys 
                 885                890                895
Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly 
             900                905                910
Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg 
         915                920                925
Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His 
     930                935                940
Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu 
 945                950                955                960
Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala 
                 965                970                975
Leu Pro Gln 
             980



<210> 3088
<211> 719
<212> DNA
<213> Rattus norvegicus
<308> L25633
<400> 3088

gtgacttcc  ggcacagcc  ccctggctg  tgtcgctac  tccactacg  tctagctcg  60
ggaaccgtg  gctcggatc  agcgaagat  cagagttcg  tgaagcccg  gggctccgg  120
gttcttcag  tactggtct  cttccttct  ctatacagt  gcccaagca  ctgcagcga  180
ataaatgcc  acgatggtc  gggccaagt  ggatcagag  agctctgga  gttccaagg  240
ctcgttgcc  cagtcttcc  gtacttaca  cttctattc  accacattg  accccaagg  300
atgttctgg  ccgatgaca  agcctatga  ttaatgacc  aaaaggtgg  gcacctcag  360
agactccat  cccagtatc  atgccggaa  gaggggaag  tggtttctc  cattgcaac  420
actggggtg  ggggcaagc  agaggagaa  cttcgactc  tatcgcccc  aaagagtcc  480
gcagtcaag  tgaataggg  ccgatgctt  accaccaaa  taatcccaa  ggccaccaa  540
caagaggtc  cccatccct  caagggttt  tttgggcca  tccccactg  gggtctcaa  600
cttgttgct  actgagatc  cactgtata  gatcctttt  cccgggaac  tcctcactg  660
cctccaagg  gcaattctt  gatgactca  atataagta  ttaaagttg  ctttcatgc  719



<210> 3089
<211> 175
<212> PRT
<213> Rattus norvegicus
<308> P47940
<400> 3089

Met Gln Ser Ser Leu Lys Pro Ala Gly Ser Gly Val Leu Gln Leu Leu 
  1               5                  10                  15
Val Cys Phe Leu Leu Leu Tyr Ser Arg Pro Ser Ser Cys Ser Asp Ile 
             20                  25                  30
Asn Ala His Asp Gly Gln Gly Gln Val Gly Ser Glu Gln Leu Trp Thr 
         35                  40                  45
Phe Gln Gly Leu Val Ala Ser Val Phe Gln Tyr Leu Gln Leu Leu Phe 
     50                  55                  60
His His Ile Val Pro Gln Gly Met Phe Trp Thr Asp Asp Ile Ala Tyr 
 65                  70                  75                  80
Glu Leu Met Thr Lys Lys Val Glu His Leu Ser Arg Leu His Pro Gln 
                 85                  90                  95
Tyr Pro Cys Arg Lys Glu Gly Lys Val Val Ser Pro Ile Ala Thr Thr 
             100                105                110
Gly Val Arg Gly Lys Gln Glu Glu Lys Leu Arg Leu Leu Ser Pro Gln 
         115                120                125
Lys Ser Pro Ala Val Lys Val Asn Arg Asp Arg Cys Phe Thr Thr Lys 
     130                135                140
Val Ile Pro Lys Ala Thr Lys Gln Glu Val Thr His Pro Ser Lys Gly 
 145                150                155                160
Phe Phe Gly Pro Phe Pro Thr Val Gly Leu Asn Leu Val Ala Asp 
                 165                170                175



<210> 3090
<211> 3649
<212> DNA
<213> Homo sapiens
<308> NM_002846
<400> 3090

gcggcaagc  ccgcctcag  ccctctggc  ggctcccgc  agcgtcgct  cggctccgg  60
ccgggagcg  gcgcccgga  ctcggaaag  tgcggcgcc  gcggcggcc  gggggtctc  120
ggggatccg  gggtctccg  ctgctcctc  gcctcctgc  gctgagcag  cgcccgggg  180
gctgcagcg  cgttagtgc  cacggctgt  tatttgacc  caggctctg  tctcacctg  240
aagtctgta  tcaggatgg  ttgtttggg  agtgccagg  gggagtggg  caggcccgg  300
cccttttgc  agtcacctc  ccagttctc  aacgcttac  aggtgtgct  cgacaactc  360
tgtcccaag  attgtcctg  cacgatgac  tcacccagt  tgtgatctc  caggagatg  420
agcgcatcc  caggcttcg  cccccagag  cccgtccaa  ggacaggtc  ggcttggca  480
ccaagagac  tggtcctgc  ggagagctg  ttttacagg  catccccac  ggctccgcc  540
ctgctgccc  gcatcggct  ccacaacca  cagtgggca  aggtggagc  ggggccagc  600
cctctctgt  ccctctgca  gctgagctg  tcccgcctc  cttggagca  ctgctgctg  660
ccccacagc  tccccaccc  tcactgagt  acgaacctg  cttgctgca  ccctacctg  720
tccaccagt  tggctcccg  gatggctcc  gggtctcag  gggctcccc  gggatggtc  780
gtgtcggcc  cctgcccaa  gctgaagcc  ctgccctct  cagcagaac  gcctccaag  840
gcatatttg  ggaccaccc  ggccactcc  acggggacc  tccagggcc  tcacctgcc  900
agctttttc  agactctgg  ctgctctat  tggcccagg  gttgccagc  cccagcagg  960
ccagggtgc  aaggctgcc  gagcaaggg  gcagcagcc  ggcagagga  tccccagag  1020
gctatgaga  ggaaggact  ggggatcgt  gagagaagc  tgcttcccc  gctgtgcag  1080
cagatgcgg  tctgcagag  ctggccgct  tgctggcgg  ctatggggt  gagctgcgt  1140
agctgaccc  tgagcagct  tccacactc  tgaccctgc  gcagctact  cccaagggt  1200
caggaagaa  tccgggagg  gttgtaaat  ttggagctg  tatcaagaa  acaatggag  1260
ggccggtgg  gggcagaga  acagcagag  ttccagccc  cacatcccc  atgcctgga  1320
accccactg  cagccctac  tccagtgaa  tccagcagg  gccaagccc  gtctcctct  1380
agcctccca  agctgccag  ccccctgtg  cacctgtcc  gctagagaa  aaaagccca  1440
tgggccaga  ccagcccac  gtggcagga  agccctcag  ccgcccagc  gcagaggaa  1500
atggctaca  cgtcactga  cagaagccc  tgagcctgg  tgcaggagt  aagctgctg  1560
agatcctgg  tgagcatgt  cacatgtcc  caggcagct  catcaacat  agtgtggtg  1620
gaccagccc  caccttccg  atccggcac  atgagcaga  cctgtcttt  gctgatgtg  1680
cccaacaag  agggctggt  aagtctgaa  tggaagcac  gacagggct  caaatcttg  1740
agacaggag  gggacagag  gaggaggca  ctgcagtcc  tccccaaac  gcgcacagc  1800
cctcaccca  gcgctcagt  ctgctcact  tggtggccc  ggcaggtgt  gctgggctg  1860
tggtggctc  ggctgtggc  ctgtgtgtg  ggcagcatg  gcggcagca  gacaaggag  1920
gcctggcag  cctggggcc  gagggggcc  atggtgaca  tacctttga  taccaggac  1980
tgtgccgcc  gcacatggc  acgaagtcc  tgttcaacc  ggcagaggg  ccaccggag  2040
cttcacggg  gagcagtgt  tcctcccag  tcagcgacg  agcccaggc  agccccagc  2100
cccacagca  caccccgtc  tggtgcgag  agccggccc  agccaacat  gacatctcc  2160
cgggacaca  gattctggc  tacatggag  atcacctgc  gaaccggga  cgccttgcc  2220
aggagtggc  ggccctctg  gcctaccaa  cagagccaa  cacctgtgc  accgcgcag  2280
gggagggca  catcaaaaa  aaccggcat  ctgacttcc  gccctatga  catgcccgc  2340
taaaactga  ggtggagag  agcccttct  ggagcgatt  catcaacgc  agccccatt  2400
ttgagcatg  ccctcggat  ccagcctac  tagccacgc  gggcccgct  tcccatacc  2460
tcgcagact  ctggcagat  gtgtgggag  gcggctgca  cgtcatcgt  atgctgacc  2520
cgctggtgg  ggatggtgt  aagcagtgt  accgctact  gccagatga  ggtgcctcc  2580
tctaccacg  atatgaggt  aacctggtg  cggagcaca  ctggtgcga  gactttctg  2640
tgcggagct  ctacctgaa  aacgtgcag  cccaggaga  gcgcacgct  acgcagttc  2700
acttcctca  ctggccggc  gagggcaca  cggcctcca  gcggcccct  ctggacttc  2760
gcaggaagg  gaacaagtg  taccggggc  gctcctgcc  catcatcgt  cactgcagt  2820
atggtgcgg  gaggaccgg  acctacatc  tcatcgaca  ggtcctgaa  cgcatggca  2880
aaggagtga  ggagattga  atcgctgcc  ccctggagc  tgtccgtga  cagcggcct  2940
gccttgtcc  ctctaagga  cagtttgaa  ttgccctga  agccgtggc  gaggaagtg  3000
atgccatcc  caaggccct  ccccagtga  accctgggg  cccttggcg  gcagcccag  3060
ctctgtccc  ctttgcctg  gtgagcatc  ctgtgtacc  actcctcac  gccccacca  3120
ccacctctt  ggcatgctc  gcccttcct  gaagagtca  gaagggaaa  ccagaaggg  3180
cacgcctgc  cagcctcgc  tgccagagc  tggggcatc  cagagccca  ggcatccca  3240
gggggtgct  cagccagga  gagaggaaa  gacatgggt  gcaattcta  ccagagcct  3300
ctcctgcct  cattccctg  cctggctct  ctgtagctc  cctggggtt  tgggagttc  3360
ctgaacatc  gtgtgtgtc  ccctatgct  cagtatgga  gaatggggt  gagggtcgc  3420
acacccggc  ccccctgct  ctcagcccc  ggcctgcct  tgactcaca  ttgggcgct  3480
tgccctccc  ggcctcacg  ccagcctcc  cccaccacc  tcccaccat  cgctgctca  3540
cctctctcc  tctggcgca  gagaacatt  ctagaaaaa  ctacttttg  accagtgtg  3600
ataaagtta  tgtgttgtc  gtgcagctg  aaaaaaaaa  aaaaaaaaa  3649



<210> 3091
<211> 979
<212> PRT
<213> Homo sapiens
<308> Q16849
<400> 3091

Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu 
  1               5                  10                  15
Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys 
             20                  25                  30
Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser 
         35                  40                  45
His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val 
     50                  55                  60
Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu 
 65                  70                  75                  80
Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser 
                 85                  90                  95
Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg 
             100                105                110
Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly 
         115                120                125
Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp 
     130                135                140
Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro 
 145                150                155                160
Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu 
                 165                170                175
Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro 
             180                185                190
Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro 
         195                200                205
Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu 
     210                215                220
Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala 
 225                230                235                240
Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His 
                 245                250                255
Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu 
             260                265                270
Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro 
         275                280                285
Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg 
     290                295                300
Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg 
 305                310                315                320
Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln 
                 325                330                335
Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu 
             340                345                350
Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro 
         355                360                365
Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp 
     370                375                380
Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu 
 385                390                395                400
Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro 
                 405                410                415
Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro 
             420                425                430
Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys 
         435                440                445
Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala 
     450                455                460
Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro 
 465                470                475                480
Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His 
                 485                490                495
Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro 
             500                505                510
Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala 
         515                520                525
Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln 
     530                535                540
Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala 
 545                550                555                560
Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser 
                 565                570                575
Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val 
             580                585                590
Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp 
         595                600                605
Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr 
     610                615                620
Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser 
 625                630                635                640
Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser 
                 645                650                655
Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His 
             660                665                670
Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp 
         675                680                685
Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg 
     690                695                700
Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln 
 705                710                715                720
Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys 
                 725                730                735
Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys 
             740                745                750
Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser 
         755                760                765
Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln 
     770                775                780
Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu 
 785                790                795                800
Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly 
                 805                810                815
Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr 
             820                825                830
His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp 
         835                840                845
Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr 
     850                855                860
Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr 
 865                870                875                880
Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys 
                 885                890                895
Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly 
             900                905                910
Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg 
         915                920                925
Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His 
     930                935                940
Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu 
 945                950                955                960
Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala 
                 965                970                975
Leu Pro Gln 
             980



<210> 3092
<211> 2245
<212> DNA
<213> Rattus norvegicus
<308> L26267
<400> 3092

agggagatt  tgaatcccc  tgagaaaga  acacaaggt  aggggccca  cctgttcat  60
gccagcacc  agaccgaag  aattgcccc  gcatccacc  tggaagaca  ggaagagga  120
gtggggttt  aggataacc  ctttcttga  aaggcgctg  agctcgcca  gcggcatgc  180
aacgccctc  tcgactacg  ggttacggg  gatgtgaag  tgctgctgg  ggtacagcg  240
catctcacc  cggtgcagg  tgagaacgg  gacagtgtc  tacacttag  catcatcca  300
cttcatgct  agctcgtga  ggatctgct  gaagtgaca  ctggttcga  ctctgatga  360
atcatcaac  tgagaaacg  tctgtatca  acacctttg  acttggccg  gatcaccaa  420
caggaagat  tggtggagg  cttgctgag  gttggggct  acctgagtc  tctggaccg  480
tggggcaac  ctgtcctgc  cctagctgc  aaagaagga  atgataaaa  cctcggggt  540
ctactcaag  acagcaagg  agcactcct  atcaaccac  ccaacgggg  aggtctgaa  600
gccattcac  tagctgtga  gagcaacag  ctgtcatgt  tgcagctgc  tgtggctgc  660
ggggcagaa  tcaacgctc  ggagcagaa  tctgggcgc  cggcactgc  cctggccgt  720
gagtacgac  acatctcgt  ggccggctg  ctgctcctg  agggtgacg  cctcgtgga  780
agcaccacc  acgatggga  gacacctct  cacatagcg  ctggaagag  gtccaccag  840
ctggcagct  ttctcaaag  agcaggagc  gaccccctg  tggagaact  tgagcctct  900
tatgacctg  acgactctt  ggagaaggc  ggagaagat  agggagtag  gccaggcac  960
acacccctg  acatggctg  caactggca  gtatttgac  tactaaatg  gaaaccata  1020
gagccagtg  tcacatctg  tgacatact  ccacaaggg  acattaagc  gctgacaga  1080
gacacgagg  tgcaactct  caagctctt  gaaattcct  atcccgaca  gaactgggc  1140
actctggcg  agaagttag  tctggggat  ttgaacaat  ccttccggc  gagtcccgc  1200
ccttctaaa  ctcttatgg  caactatga  gtctctggg  ggaccatca  agagctggt  1260
gaggccctg  gacagatgg  ctacacaga  gccattgaa  tgatccagg  agccttccg  1320
accccggaa  ccacagcct  cagccccgt  accactgct  aggcccact  gctgcctct  1380
tcgtcctcc  ccacaagac  gcacataga  gagctccga  ataatgaca  cgtgtgtga  1440
agtggtgtg  agacatcct  ccgcaaact  agcttctcg  agtccctca  tggagatgg  1500
ccactgcta  ctctgaaca  aatgcctca  aattatggg  aggatggac  tatagaagg  1560
aaaatttag  ctgctggcg  ttccccaca  tgtaaacca  agccctgaa  ggccatcat  1620
tcgttccga  ggagaaggc  aaaaacgca  cccaaggtg  tggaaggtc  ccggcctgc  1680
gggtcaatc  tgatgtcat  cgaggcctt  cgaatttgg  ttcctttct  ggctctgaa  1740
tgaaattta  ttgtcatat  cagatggtg  ctagcaatc  cggctgcac  cggtgtggc  1800
tggggtatg  tggcttgag  ttttccagc  gctattgga  tacacttgc  ttgtgttgt  1860
actgctgtc  ctctgctgg  tccccgctg  cattaaggt  tcgcagtcc  cacctggtg  1920
tctttctag  catctacag  acagtcatg  actcaaatt  agattaagg  aaaagatat  1980
tttaagtga  taacttcat  cgcaataaa  aaaagacat  gctttttct  atgtggttt  2040
tctgtgatt  aaaaaaaaa  aacacatga  cttaacaat  tttaaaacc  gctacaatc  2100
gtgctgaaa  tagtatttt  ccccttttc  gcattttac  attgtaaat  tgttttcta  2160
atcaaatac  ttaaaagaa  aaatgttgg  tttataaat  ctatttttt  ttttacttt  2220
ataataaaa  tacaagcac  ctgtt  2245



<210> 3093
<211> 522
<212> PRT
<213> Rattus norvegicus
<308> Q63369
<400> 3093

Arg Glu Ile Leu Asn Pro Pro Glu Lys Glu Thr Gln Gly Glu Gly Pro 
  1               5                  10                  15
Ser Leu Phe Met Ala Ser Thr Lys Thr Glu Ala Ile Ala Pro Ala Ser 
             20                  25                  30
Thr Met Glu Asp Lys Glu Glu Asp Val Gly Phe Gln Asp Asn Leu Phe 
         35                  40                  45
Leu Glu Lys Ala Leu Gln Leu Ala Lys Arg His Ala Asn Ala Leu Phe 
     50                  55                  60
Asp Tyr Ala Val Thr Gly Asp Val Lys Met Leu Leu Ala Val Gln Arg 
 65                  70                  75                  80
His Leu Thr Ala Val Gln Asp Glu Asn Gly Asp Ser Val Leu His Leu 
                 85                  90                  95
Ala Ile Ile His Leu His Ala Gln Leu Val Arg Asp Leu Leu Glu Val 
             100                105                110
Thr Ser Gly Ser Ile Ser Asp Asp Ile Ile Asn Met Arg Asn Asp Leu 
         115                120                125
Tyr Gln Thr Pro Leu His Leu Ala Val Ile Thr Lys Gln Glu Asp Val 
     130                135                140
Val Glu Asp Leu Leu Arg Val Gly Ala Asp Leu Ser Leu Leu Asp Arg 
 145                150                155                160
Trp Gly Asn Ser Val Leu His Leu Ala Ala Lys Glu Gly His Asp Lys 
                 165                170                175
Ile Leu Gly Val Leu Leu Lys Asn Ser Lys Ala Ala Leu Leu Ile Asn 
             180                185                190
His Pro Asn Gly Glu Gly Leu Asn Ala Ile His Ile Ala Val Met Ser 
         195                200                205
Asn Ser Leu Ser Cys Leu Gln Leu Leu Val Ala Ala Gly Ala Glu Val 
     210                215                220
Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr Ala Leu His Leu Ala Val 
 225                230                235                240
Glu Tyr Asp Asn Ile Ser Leu Ala Gly Cys Leu Leu Leu Glu Gly Asp 
                 245                250                255
Ala Leu Val Asp Ser Thr Thr Tyr Asp Gly Thr Thr Pro Leu His Ile 
             260                265                270
Ala Ala Gly Arg Gly Ser Thr Arg Leu Ala Ala Leu Leu Lys Ala Ala 
         275                280                285
Gly Ala Asp Pro Leu Val Glu Asn Phe Glu Pro Leu Tyr Asp Leu Asp 
     290                295                300
Asp Ser Trp Glu Lys Ala Gly Glu Asp Glu Gly Val Val Pro Gly Thr 
 305                310                315                320
Thr Pro Leu Asp Met Ala Ala Asn Trp Gln Val Phe Asp Ile Leu Asn 
                 325                330                335
Gly Lys Pro Tyr Glu Pro Val Phe Thr Ser Asp Asp Ile Leu Pro Gln 
             340                345                350
Gly Asp Ile Lys Gln Leu Thr Glu Asp Thr Arg Leu Gln Leu Cys Lys 
         355                360                365
Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn Trp Ala Thr Leu Ala Gln 
     370                375                380
Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala Phe Arg Leu Ser Pro Ala 
 385                390                395                400
Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu Val Ser Gly Gly Thr Ile 
                 405                410                415
Lys Glu Leu Val Glu Ala Leu Arg Gln Met Gly Tyr Thr Glu Ala Ile 
             420                425                430
Glu Val Ile Gln Ala Ala Phe Arg Thr Pro Glu Thr Thr Ala Ser Ser 
         435                440                445
Pro Val Thr Thr Ala Gln Ala His Leu Leu Pro Leu Ser Ser Ser Ser 
     450                455                460
Thr Arg Gln His Ile Asp Glu Leu Arg Asp Asn Asp Ser Val Cys Asp 
 465                470                475                480
Ser Gly Val Glu Thr Ser Phe Arg Lys Leu Ser Phe Ser Glu Ser Leu 
                 485                490                495
Thr Gly Asp Gly Pro Leu Leu Ser Leu Asn Lys Met Pro His Asn Tyr 
             500                505                510
Gly Gln Asp Gly Pro Ile Glu Gly Lys Ile 
         515                520



<210> 3094
<211> 233
<212> DNA
<213> Homo sapiens
<308> AI265879
<400> 3094

ttttttttt  ttttttttt  ttttttttt  ttaaattgg  tttcccttt  attataaaa  60
taaaaaaaa  aatagcatt  ataaatcca  cattttttc  tttaaggtt  tggatctaa  120
aaacatttt  ccaatagca  aaggcagaa  ggggggaaa  tcccatttt  agcagggat  180
ggacccatg  taaaatatg  ccaggtttt  ttttttttt  ttttttttg  caa  233



<210> 3095
<211> 968
<212> PRT
<213> Homo sapiens
<308> XP_028204
<400> 3095

Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His 
  1               5                  10                  15
Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln 
             20                  25                  30
Pro Gln Met Ala Leu Pro Thr Asp Gly Pro Tyr Leu Gln Ile Leu Glu 
         35                  40                  45
Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly Pro 
     50                  55                  60
Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys Ser 
 65                  70                  75                  80
Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val Ile 
                 85                  90                  95
Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His Ser 
             100                105                110
Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala Gly 
         115                120                125
Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His Val 
     130                135                140
Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu Ala 
 145                150                155                160
Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu Ala 
                 165                170                175
Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg Glu 
             180                185                190
Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met Asp 
         195                200                205
Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser Thr 
     210                215                220
Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile Tyr 
 225                230                235                240
Asp Ser Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met Asp 
                 245                250                255
Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu Cys 
             260                265                270
Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu Glu 
         275                280                285
Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr Asp 
     290                295                300
Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys Asp 
 305                310                315                320
Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg Lys 
                 325                330                335
Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro Glu 
             340                345                350
Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met Pro 
         355                360                365
Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly Gly 
     370                375                380
Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser Thr 
 385                390                395                400
Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly Gly 
                 405                410                415
Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys His 
             420                425                430
Gly Thr Met Asp Thr Glu Ser Lys Lys Asp Pro Glu Gly Cys Asp Lys 
         435                440                445
Ser Asp Asp Lys Asn Thr Val Asn Leu Phe Gly Lys Val Ile Glu Thr 
     450                455                460
Thr Glu Gln Asp Gln Glu Pro Ser Glu Ala Thr Val Gly Asn Gly Glu 
 465                470                475                480
Val Thr Leu Thr Tyr Ala Thr Gly Thr Lys Glu Glu Ser Ala Gly Val 
                 485                490                495
Gln Asp Asn Leu Phe Leu Glu Lys Ala Met Gln Leu Ala Lys Arg His 
             500                505                510
Ala Asn Ala Leu Phe Asp Tyr Ala Val Thr Gly Asp Val Lys Met Leu 
         515                520                525
Leu Ala Val Gln Arg His Leu Thr Ala Val Gln Asp Glu Asn Gly Asp 
     530                535                540
Ser Val Leu His Leu Ala Ile Ile His Leu His Ser Gln Leu Val Arg 
 545                550                555                560
Asp Leu Leu Glu Val Thr Ser Gly Leu Ile Ser Asp Asp Ile Ile Asn 
                 565                570                575
Met Arg Asn Asp Leu Tyr Gln Thr Pro Leu His Leu Ala Val Ile Thr 
             580                585                590
Lys Gln Glu Asp Val Val Glu Asp Leu Leu Arg Ala Gly Ala Asp Leu 
         595                600                605
Ser Leu Leu Asp Arg Leu Gly Asn Ser Val Leu His Leu Ala Ala Lys 
     610                615                620
Glu Gly His Asp Lys Val Leu Ser Ile Leu Leu Lys His Lys Lys Ala 
 625                630                635                640
Ala Leu Leu Leu Asp His Pro Asn Gly Asp Gly Leu Asn Ala Ile His 
                 645                650                655
Leu Ala Met Met Ser Asn Ser Leu Pro Cys Leu Leu Leu Leu Val Ala 
             660                665                670
Ala Gly Ala Asp Val Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr Ala 
         675                680                685
Leu His Leu Ala Val Glu His Asp Asn Ile Ser Leu Ala Gly Cys Leu 
     690                695                700
Leu Leu Glu Gly Asp Ala His Val Asp Ser Thr Thr Tyr Asp Gly Thr 
 705                710                715                720
Thr Pro Leu His Ile Ala Ala Gly Arg Gly Ser Thr Arg Leu Ala Ala 
                 725                730                735
Leu Leu Lys Ala Ala Gly Ala Asp Pro Leu Val Glu Asn Phe Glu Pro 
             740                745                750
Leu Tyr Asp Leu Asp Asp Ser Trp Glu Asn Ala Gly Glu Asp Glu Gly 
         755                760                765
Val Val Pro Gly Thr Thr Pro Leu Asp Met Ala Thr Ser Trp Gln Val 
     770                775                780
Phe Asp Ile Leu Asn Gly Lys Pro Tyr Glu Pro Glu Phe Thr Ser Asp 
 785                790                795                800
Asp Leu Leu Ala Gln Gly Asp Met Lys Gln Leu Ala Glu Asp Val Lys 
                 805                810                815
Leu Gln Leu Tyr Lys Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn Trp 
             820                825                830
Ala Thr Leu Ala Gln Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala Phe 
         835                840                845
Arg Leu Ser Pro Ala Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu Val 
     850                855                860
Ser Gly Gly Thr Val Arg Glu Leu Val Glu Ala Leu Arg Gln Met Gly 
 865                870                875                880
Tyr Thr Glu Ala Ile Glu Val Ile Gln Ala Ala Ser Ser Pro Val Lys 
                 885                890                895
Thr Thr Ser Gln Ala His Ser Leu Pro Leu Ser Pro Ala Ser Thr Arg 
             900                905                910
Gln Gln Ile Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Ser Gly 
         915                920                925
Val Glu Thr Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser Leu Thr Ser 
     930                935                940
Gly Ala Ser Leu Leu Thr Leu Asn Lys Met Pro His Asp Tyr Gly Gln 
 945                950                955                960
Glu Gly Pro Leu Glu Gly Lys Ile 
                 965



<210> 3096
<211> 1464
<212> DNA
<213> Rattus norvegicus
<308> L26268
<400> 3096

atgcatccc  tctacactc  ggccgccac  atgataggc  agatcgccg  cgcggtgtc  60
ttcatctcc  agttcctcc  caccaaggg  ctcacgagc  agcgacagc  gcagacttt  120
agccagagc  tgcaggaac  gctggcaga  cattacaaa  atcactggt  cccagaaaa  180
ccgtgcaag  gatcaggtt  ccgttgtat  cgcatcaac  ataagatgg  tcctctgat  240
ggacaggca  cccagcgga  tggactgag  agtcaagag  tgttcaggc  tctcccaag  300
gaactcaca  tctgggttg  cccctacga  gtgtcctac  ggattggag  ggatggctc  360
atctgtgtg  tgtatgaag  ctcaccagc  ggaggtagc  ctcaaaaca  caccaacgt  420
caaatggta  acagcagaa  cagctgtaa  gaggaactt  tcttgggca  aacaagccc  480
tccaaaaac  acaatatga  gactgtatc  ggttaagat  tagtctatg  atggatcat  540
ttataatgg  tggatagat  tgatttttt  ctttgggtg  gctcctctt  gggatggat  600
atggaataa  catgtcaca  ctgtgaaga  ctggcacaa  atagagtgg  aataatttt  660
ttttttaaa  tgacagtgc  atagtttgg  cagtacctt  aagtgattt  agtagcctg  720
gagtccaag  aaaggatca  tttatttgg  agggagtga  gtcgcaggg  ggtttcagt  780
tctcccaga  cttataccc  atttgtcac  ccagtccct  taaggaaat  ctgtatttc  840
aagaaccct  ttttgcagt  agtcaacct  gcaggggaa  ttgcactat  tacacttga  900
agttaccag  aactttttt  tggcagctc  ataggaaag  tcaatgttc  aagcatggt  960
gtactggaa  tattacacg  agactttta  ctagcactt  aaaatgtat  aatgtacat  1020
aagacactt  gtacgcatg  cctggggga  atggtcaga  cttgtgttt  tggctttga  1080
agtagcaag  gaccggaat  tgccatgac  acaggcttt  aaaagaccc  tacaaagac  1140
ctgtctcaa  tgtggttag  accagccag  tctctgtac  ttcgcttgt  gttttctaa  1200
attgagtga  taaacttct  atttttaga  agtggaggt  tggtttgta  ctttccttg  1260
actcaattg  gtaagagtc  ttttccaca  accgccatc  attttgtga  ctttgttag  1320
catctttta  ttggtaaat  atgaactgg  gtaaatttg  acagttcat  tatattgat  1380
gtggcaaag  tgtacagat  tctatattt  ggatgagaa  tttttcttc  ctctataat  1440
aattgtttc  tatcttggc  tttt  1464



<210> 3097
<211> 171
<212> PRT
<213> Rattus norvegicus
<308> Q63073
<400> 3097

Met His Pro Phe Tyr Thr Arg Ala Ala Thr Met Ile Gly Glu Ile Ala 
  1               5                  10                  15
Ala Ala Val Ser Phe Ile Ser Lys Phe Leu Arg Thr Lys Gly Leu Thr 
             20                  25                  30
Ser Glu Arg Gln Leu Gln Thr Phe Ser Gln Ser Leu Gln Glu Leu Leu 
         35                  40                  45
Ala Glu His Tyr Lys His His Trp Phe Pro Glu Lys Pro Cys Lys Gly 
     50                  55                  60
Ser Gly Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Leu Ile 
 65                  70                  75                  80
Gly Gln Ala Ala Gln Arg Ile Gly Leu Ser Ser Gln Glu Leu Phe Arg 
                 85                  90                  95
Leu Leu Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser 
             100                105                110
Tyr Arg Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Ala Ser 
         115                120                125
Pro Ala Gly Gly Ser Ser Gln Asn Ser Thr Asn Val Gln Met Val Asp 
     130                135                140
Ser Arg Ile Ser Cys Lys Glu Glu Leu Leu Leu Gly Arg Thr Ser Pro 
 145                150                155                160
Ser Lys Asn Tyr Asn Met Met Thr Val Ser Gly 
                 165                170



<210> 3098
<211> 982
<212> DNA
<213> Homo sapiens
<308> BC016759
<400> 3098

ggcacgagg  ggagctgga  atgcagcta  tgaggtctt  gaatgctgc  gagctggag  60
cggaggcag  tggggaggt  cgagcgatg  gaccaggcc  ccatcgctc  tctcttcct  120
tctcctgcc  cctcctgtc  cgaaaataa  ttttttagt  taaaaaaag  aagacaaaa  180
tagtcgtcc  cccctcacg  cctctcttc  tctcagcct  ccgcccggt  aggaagccc  240
gggtggctg  tccgccgtc  gggccgcgc  gccgagccc  ggccgcccc  ggccgcccc  300
gcacgccgc  cccatgcat  ccttctaca  ccgggccgc  accatgata  gcgagatcg  360
cgccgccgt  tccttcatc  ccaagtttc  ccgcaccaa  gggctcacg  gcgagcgac  420
gctgcagac  ttcagccag  gcctgcagg  gctgctggc  gaacattat  aacatcact  480
gttcccaga  aagccatgc  agggatcgg  ttaccgttg  attcgcatc  accataaaa  540
ggatcctct  attggacag  cagcacagc  gattggact  agcagtcag  agctgttca  600
gcttctccc  agtgaactc  cactctggg  tgaccccta  gaagtgtcc  acagaattg  660
agaggatgg  tccatctgt  tgctgtatg  agcctcacc  gcaggaggt  gcactcaaa  720
cagcaccaa  gtgcaaatg  tagacagcc  aatcagctg  aaggaggaa  ttctcttgg  780
cagaacgag  ccttccaaa  actacaata  gatgactgt  tcaggttaa  atatagtct  840
tggatggat  atctgatga  gatggataa  tttgatttt  gctttgggt  ggctcctct  900
ggggatgga  tatggaatt  aaaccatgt  acagctgtg  agatctggc  caagataga  960
tggtaaaaa  aaaaaaaaa  aa  982



<210> 3099
<211> 171
<212> PRT
<213> Homo sapiens
<308> P31607
<400> 3099

Met His Pro Phe Tyr Thr Arg Ala Ala Thr Met Ile Gly Glu Ile Ala 
  1               5                  10                  15
Ala Ala Val Ser Phe Ile Ser Lys Phe Leu Arg Thr Lys Gly Leu Thr 
             20                  25                  30
Ser Glu Arg Gln Leu Gln Thr Phe Ser Gln Ser Leu Gln Glu Leu Leu 
         35                  40                  45
Ala Glu His Tyr Lys His His Trp Phe Pro Glu Lys Pro Cys Lys Gly 
     50                  55                  60
Ser Gly Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Leu Ile 
 65                  70                  75                  80
Gly Gln Ala Ala Gln Arg Ile Gly Leu Ser Ser Gln Glu Leu Phe Arg 
                 85                  90                  95
Leu Leu Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser 
             100                105                110
Tyr Arg Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Ala Ser 
         115                120                125
Pro Ala Gly Gly Ser Thr Gln Asn Ser Thr Asn Val Gln Met Val Asp 
     130                135                140
Ser Arg Ile Ser Cys Lys Glu Glu Leu Leu Leu Gly Arg Thr Ser Pro 
 145                150                155                160
Ser Lys Asn Tyr Asn Met Met Thr Val Ser Gly 
                 165                170



<210> 3100
<211> 1464
<212> DNA
<213> Rattus norvegicus
<308> L26268
<400> 3100

atgcatccc  tctacactc  ggccgccac  atgataggc  agatcgccg  cgcggtgtc  60
ttcatctcc  agttcctcc  caccaaggg  ctcacgagc  agcgacagc  gcagacttt  120
agccagagc  tgcaggaac  gctggcaga  cattacaaa  atcactggt  cccagaaaa  180
ccgtgcaag  gatcaggtt  ccgttgtat  cgcatcaac  ataagatgg  tcctctgat  240
ggacaggca  cccagcgga  tggactgag  agtcaagag  tgttcaggc  tctcccaag  300
gaactcaca  tctgggttg  cccctacga  gtgtcctac  ggattggag  ggatggctc  360
atctgtgtg  tgtatgaag  ctcaccagc  ggaggtagc  ctcaaaaca  caccaacgt  420
caaatggta  acagcagaa  cagctgtaa  gaggaactt  tcttgggca  aacaagccc  480
tccaaaaac  acaatatga  gactgtatc  ggttaagat  tagtctatg  atggatcat  540
ttataatgg  tggatagat  tgatttttt  ctttgggtg  gctcctctt  gggatggat  600
atggaataa  catgtcaca  ctgtgaaga  ctggcacaa  atagagtgg  aataatttt  660
ttttttaaa  tgacagtgc  atagtttgg  cagtacctt  aagtgattt  agtagcctg  720
gagtccaag  aaaggatca  tttatttgg  agggagtga  gtcgcaggg  ggtttcagt  780
tctcccaga  cttataccc  atttgtcac  ccagtccct  taaggaaat  ctgtatttc  840
aagaaccct  ttttgcagt  agtcaacct  gcaggggaa  ttgcactat  tacacttga  900
agttaccag  aactttttt  tggcagctc  ataggaaag  tcaatgttc  aagcatggt  960
gtactggaa  tattacacg  agactttta  ctagcactt  aaaatgtat  aatgtacat  1020
aagacactt  gtacgcatg  cctggggga  atggtcaga  cttgtgttt  tggctttga  1080
agtagcaag  gaccggaat  tgccatgac  acaggcttt  aaaagaccc  tacaaagac  1140
ctgtctcaa  tgtggttag  accagccag  tctctgtac  ttcgcttgt  gttttctaa  1200
attgagtga  taaacttct  atttttaga  agtggaggt  tggtttgta  ctttccttg  1260
actcaattg  gtaagagtc  ttttccaca  accgccatc  attttgtga  ctttgttag  1320
catctttta  ttggtaaat  atgaactgg  gtaaatttg  acagttcat  tatattgat  1380
gtggcaaag  tgtacagat  tctatattt  ggatgagaa  tttttcttc  ctctataat  1440
aattgtttc  tatcttggc  tttt  1464



<210> 3101
<211> 171
<212> PRT
<213> Rattus norvegicus
<308> Q63073
<400> 3101

Met His Pro Phe Tyr Thr Arg Ala Ala Thr Met Ile Gly Glu Ile Ala 
  1               5                  10                  15
Ala Ala Val Ser Phe Ile Ser Lys Phe Leu Arg Thr Lys Gly Leu Thr 
             20                  25                  30
Ser Glu Arg Gln Leu Gln Thr Phe Ser Gln Ser Leu Gln Glu Leu Leu 
         35                  40                  45
Ala Glu His Tyr Lys His His Trp Phe Pro Glu Lys Pro Cys Lys Gly 
     50                  55                  60
Ser Gly Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Leu Ile 
 65                  70                  75                  80
Gly Gln Ala Ala Gln Arg Ile Gly Leu Ser Ser Gln Glu Leu Phe Arg 
                 85                  90                  95
Leu Leu Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser 
             100                105                110
Tyr Arg Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Ala Ser 
         115                120                125
Pro Ala Gly Gly Ser Ser Gln Asn Ser Thr Asn Val Gln Met Val Asp 
     130                135                140
Ser Arg Ile Ser Cys Lys Glu Glu Leu Leu Leu Gly Arg Thr Ser Pro 
 145                150                155                160
Ser Lys Asn Tyr Asn Met Met Thr Val Ser Gly 
                 165                170



<210> 3102
<211> 982
<212> DNA
<213> Homo sapiens
<308> BC016759
<400> 3102

ggcacgagg  ggagctgga  atgcagcta  tgaggtctt  gaatgctgc  gagctggag  60
cggaggcag  tggggaggt  cgagcgatg  gaccaggcc  ccatcgctc  tctcttcct  120
tctcctgcc  cctcctgtc  cgaaaataa  ttttttagt  taaaaaaag  aagacaaaa  180
tagtcgtcc  cccctcacg  cctctcttc  tctcagcct  ccgcccggt  aggaagccc  240
gggtggctg  tccgccgtc  gggccgcgc  gccgagccc  ggccgcccc  ggccgcccc  300
gcacgccgc  cccatgcat  ccttctaca  ccgggccgc  accatgata  gcgagatcg  360
cgccgccgt  tccttcatc  ccaagtttc  ccgcaccaa  gggctcacg  gcgagcgac  420
gctgcagac  ttcagccag  gcctgcagg  gctgctggc  gaacattat  aacatcact  480
gttcccaga  aagccatgc  agggatcgg  ttaccgttg  attcgcatc  accataaaa  540
ggatcctct  attggacag  cagcacagc  gattggact  agcagtcag  agctgttca  600
gcttctccc  agtgaactc  cactctggg  tgaccccta  gaagtgtcc  acagaattg  660
agaggatgg  tccatctgt  tgctgtatg  agcctcacc  gcaggaggt  gcactcaaa  720
cagcaccaa  gtgcaaatg  tagacagcc  aatcagctg  aaggaggaa  ttctcttgg  780
cagaacgag  ccttccaaa  actacaata  gatgactgt  tcaggttaa  atatagtct  840
tggatggat  atctgatga  gatggataa  tttgatttt  gctttgggt  ggctcctct  900
ggggatgga  tatggaatt  aaaccatgt  acagctgtg  agatctggc  caagataga  960
tggtaaaaa  aaaaaaaaa  aa  982



<210> 3103
<211> 171
<212> PRT
<213> Homo sapiens
<308> P31607
<400> 3103

Met His Pro Phe Tyr Thr Arg Ala Ala Thr Met Ile Gly Glu Ile Ala 
  1               5                  10                  15
Ala Ala Val Ser Phe Ile Ser Lys Phe Leu Arg Thr Lys Gly Leu Thr 
             20                  25                  30
Ser Glu Arg Gln Leu Gln Thr Phe Ser Gln Ser Leu Gln Glu Leu Leu 
         35                  40                  45
Ala Glu His Tyr Lys His His Trp Phe Pro Glu Lys Pro Cys Lys Gly 
     50                  55                  60
Ser Gly Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Leu Ile 
 65                  70                  75                  80
Gly Gln Ala Ala Gln Arg Ile Gly Leu Ser Ser Gln Glu Leu Phe Arg 
                 85                  90                  95
Leu Leu Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser 
             100                105                110
Tyr Arg Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Ala Ser 
         115                120                125
Pro Ala Gly Gly Ser Thr Gln Asn Ser Thr Asn Val Gln Met Val Asp 
     130                135                140
Ser Arg Ile Ser Cys Lys Glu Glu Leu Leu Leu Gly Arg Thr Ser Pro 
 145                150                155                160
Ser Lys Asn Tyr Asn Met Met Thr Val Ser Gly 
                 165                170



<210> 3104
<211> 4601
<212> DNA
<213> Rattus norvegicus
<308> L26986
<400> 3104

ccagaactc  cgctgtcag  atttgctct  gaagtggcc  caaccagga  ggaaccgaa  60
agagagctt  atccagcac  cctccaaat  aactgtttg  tgacttgtt  gtgttaagg  120
taccacctt  ctcctgccc  cccgcgggg  gccctgcca  ctcaccatc  cccacacct  180
ctgcctcat  gcgcccgcc  ccagctcct  cccgactcc  catgccggc  caatggagt  240
atccgaagg  cgatgattg  agccacagc  gctaactta  cacccatcc  agccatcgg  300
cacccttgg  cagcctttc  gcagccgcc  agacgtggg  gtccagagt  cagtgccgc  360
gccaggacc  gcccgacgc  cagcagaag  gcggcgccc  ggcgcctct  agagaagac  420
gcgccaaga  gctgagcct  gagccagcc  aggagcttg  gcgcagaaa  ggactgcgt  480
gctcagagt  ccgaggatt  cgtggacaa  tagccacca  tttcactgc  tatcccaac  540
gagctgatt  gcgggaagg  ggcttgcca  tacgcaggg  tccactgca  tctgccagg  600
gccccttgc  ctcgggctc  ctatgactt  acctgtggg  gccctgctc  gggctcctg  660
aatcgagca  cctaggaaa  aggggatcg  tgccaagcg  ccttcgggt  tctaaaaac  720
cctacccgc  actgccaca  ccagtgtct  agcctccct  cctgcggac  ccagccatg  780
aactctcgg  tgtgcactg  cttagcggc  gcgaggaac  ctataccat  cacccgacg  840
ccccggccg  ggacggcgg  agcggctct  ggccgcagc  gctgctgtg  cagacggcg  900
tgcggcaca  caccgagca  cgcttcatc  acggccacc  aggcggcgg  ggcgggggc  960
cccgcaaag  ctcgaaccc  gcgggcagc  gaccaaacc  ccacgcgcc  cagctgtct  1020
gcgactcgg  gctgcctct  tattctctg  gctccggag  gcgagcgca  aacaccggt  1080
gcaccaaag  ctttccgga  cgcagcggg  gcggcagtg  cagtggcag  gggggtggg  1140
gcgacttgg  cttcctgca  cttgactgt  ccccaagta  ctcggattt  ttcctcaat  1200
ggggataca  ctaccgtgg  gtcattttc  caaccctac  caactcctt  aagtctcgg  1260
atctggagc  cctctatca  cgctatttc  tgggccaga  gcgcaaatc  gaggtagtg  1320
tgaacgtgc  ggatgtact  accaaactc  cccttctag  ccttcactt  agcctagcc  1380
cggctccca  ggaccctct  aagggcatc  tgctaggct  tttcactgg  atcgaggtg  1440
tgatctgcg  cctcgtggt  gtcaggaag  acaccacct  ccacactta  ctgcaatac  1500
gcggcgtgg  cacttgggt  gctatgacc  cccagattc  ggcagcagg  ctgggctat  1560
ggcttctgg  cgacggcat  ggctacgtg  tttttacac  cttcgccac  tacagcatg  1620
ttccgctgc  tctcacctg  gccatcttg  ccggcctgg  cacatcctt  ctgcaagtc  1680
cacttcaag  gctcatacc  agactagcg  tcttttcca  caaccaggt  ctggcccag  1740
tggtgctct  catgtgcat  aatacagca  gcatcttca  cagttacct  tcagaccgc  1800
cccagcggc  ggccttcct  gagacccgg  ggtgtgtgg  ggccaggct  cgcctggag  1860
cagagaacc  aagacagga  cggcttgtg  tctctgtgc  ccccaggtt  gtcgtccta  1920
aaatgatca  tgacatgac  aatgtggag  acgagcacc  gcagcatca  ttccaccgc  1980
tctacatcc  tcgctacga  aacgtcagt  ttctttttg  agatgtcaa  ggatttacc  2040
acctctcta  gaccttgtc  gctcaggag  ttgtcagga  gctcaacga  ctctttgcc  2100
gatttgatc  gctggccca  gagcatcac  gtcttcgca  taaaatcct  ggggactgc  2160
actactgtg  gtcaggact  cctgagccc  gccaggacc  tgctcattg  tgtgttgaa  2220
tgggcctca  catgatcaa  actatcagg  ttgtgaggt  cagaacgaa  catgatgtt  2280
acatgcgaa  tggaatcca  tcaggctct  tgctgtgtg  tgtgttggg  ctgagaaaa  2340
ggcagtttg  tgtctggtc  tgggatgtg  acatcgcaa  caaacttga  tctggagga  2400
tccctggga  aattcacat  tccaaagcc  cactggatt  cctcagtgg  gactataat  2460
tggaagagg  ccacggtaa  gagaggaat  aattcttga  gaagcataa  atagagacc  2520
atttgatta  gcagcccga  gagagtttg  tatccttgc  tgaagatat  gttaaggag  2580
cggtgagct  ctcggacag  agaaacagt  gggcaacgt  cacagaagg  tcctggagc  2640
cagaactgc  attcgacaa  atcgtgggc  aacagaata  tctggctgc  ctaacaaga  2700
attcaataa  tctgcttcc  aaccatctc  cacaagctt  gcatgtcca  tctgggcct  2760
aggaaatta  caagagaat  gagcatacc  tcgacttgc  gagtggcga  aagttgaga  2820
gagagcata  caagccatt  tcactgatg  ttaaagact  cagcctgga  cacaagtat  2880
ctcaaatgc  ggatgaagt  ttcaagtca  acttggtct  tgcatttat  gttcttctg  2940
ttatcactg  gattcaaag  ttgcttcct  cttcgaggc  gatgcctat  accatccag  3000
tctccatcc  gatcatgct  cactccgcc  tggtcctca  caccacggc  gaagactat  3060
agtgtctgc  tctcattct  cgcaaaacc  gttgttgga  taacgagac  tatttggcc  3120
gcaacgtca  catctttgc  tccatcttg  ttaatttcc  gggagccgt  ataaatatt  3180
tgtggtgtg  ttttgacaa  tcgataccc  tgaagaacc  gactttcaa  tcctcagct  3240
tgtttacag  tatctgctc  tacccagag  actttgtct  cactggggt  ttggccatg  3300
tgacgtgtg  agtatttct  cggcttaac  ctgtcctga  gctggctgt  ctgctcatt  3360
tgatcgcca  ctacgccct  ctgacagag  ccatctatg  aggtctctt  ctgagttat  3420
acaacctga  ccacagtgg  gaagatttt  tggggacca  ggaggcatc  ctgctactg  3480
tggccatgt  ccttcttgc  gtattctac  atggacagc  gctggagta  acagcccgc  3540
tagatttcc  gtggcgagt  caggccaaa  aggagatca  cgagatgaa  gacttgagg  3600
aacacaatg  gaacatgct  cgcaatatc  tacccggcc  cgtggcccg  cacttcctg  3660
agaaagaca  agacaatga  gagctgtat  ctcaatcct  tgatgccgt  ggggtaatg  3720
ttgcctcca  tcctggatt  gcagacttt  actctcaga  agaaatgaa  aaccaggga  3780
tggaatgtc  gcgcttgct  aatgagatc  ttgctgact  tgatgagtt  cttggagag  3840
accgctttc  ggacataga  aagattaag  ccattggta  tacatacat  gctgtctca  3900
gactgtcac  agagaaaca  caatgtgaa  ataaatggg  acatttgtg  gccctggct  3960
acttctctc  tgccctgac  gaaagcata  aagagatca  caagcattc  ttcaacaat  4020
ttgaactcc  tattggcat  agccatggc  cagtggtag  aggtgtaat  ggcgctaag  4080
aaccacagt  tgacatttg  ggtaaaact  tgaacttgg  aagccgaat  gacagcaca  4140
gagtgagtg  ccggatcca  gttcctgag  agacctatc  catcctgaa  gatcagggc  4200
ttgccttcg  ctaccgggg  gagatatat  tgaagggca  cagcgaaca  gaagggaaa  4260
tcaaaacat  ttttctcct  ggacgagtc  aacccaacc  attcatctt  cccccaaga  4320
gacttcctg  gcagtactc  ctggctgca  ttgtccttg  gcttgtcca  tctctcaac  4380
ggcaaaggc  gaagcaact  ctcaatgag  acagcaact  tggcatcat  aagagccat  4440
acaaccggc  gactttgct  acgccaagt  ggccagagc  tggagcaca  gctgaaggc  4500
ctgacaaat  cgatttgcc  taaaagcat  ttctttgtg  ttctttctc  ttttttgta  4560
ttcttttat  tataaaata  atatactaa  aaaaaggtt  g  4601



<210> 3105
<211> 1248
<212> PRT
<213> Rattus norvegicus
<308> P40146
<400> 3105

Met Glu Leu Ser Asp Val His Cys Leu Ser Gly Ser Glu Glu Leu Tyr 
  1               5                  10                  15
Thr Ile His Pro Thr Pro Pro Ala Ala Asp Gly Gly Ser Gly Ser Arg 
             20                  25                  30
Pro Gln Arg Leu Leu Trp Gln Thr Ala Val Arg His Ile Thr Glu Gln 
         35                  40                  45
Arg Phe Ile His Gly His Arg Gly Gly Gly Gly Gly Gly Ser Arg Lys 
     50                  55                  60
Ala Ser Asn Pro Ala Gly Ser Gly Pro Asn His His Ala Pro Gln Leu 
 65                  70                  75                  80
Ser Ser Asp Ser Val Leu Pro Leu Tyr Ser Leu Gly Ser Gly Glu Arg 
                 85                  90                  95
Ala His Asn Thr Gly Gly Thr Lys Val Phe Pro Glu Arg Ser Gly Ser 
             100                105                110
Gly Ser Ala Ser Gly Ser Gly Gly Gly Gly Asp Leu Gly Phe Leu His 
         115                120                125
Leu Asp Cys Ala Pro Ser Asn Ser Asp Phe Phe Leu Asn Gly Gly Tyr 
     130                135                140
Ser Tyr Arg Gly Val Ile Phe Pro Thr Leu Arg Asn Ser Phe Lys Ser 
 145                150                155                160
Arg Asp Leu Glu Arg Leu Tyr Gln Arg Tyr Phe Leu Gly Gln Arg Arg 
                 165                170                175
Lys Ser Glu Val Val Met Asn Val Leu Asp Val Leu Thr Lys Leu Thr 
             180                185                190
Leu Leu Val Leu His Leu Ser Leu Ala Ser Ala Pro Met Asp Pro Leu 
         195                200                205
Lys Gly Ile Leu Leu Gly Phe Phe Thr Gly Ile Glu Val Val Ile Cys 
     210                215                220
Ala Leu Val Val Val Arg Lys Asp Thr Thr Ser His Thr Tyr Leu Gln 
 225                230                235                240
Tyr Ser Gly Val Val Thr Trp Val Ala Met Thr Thr Gln Ile Leu Ala 
                 245                250                255
Ala Gly Leu Gly Tyr Gly Leu Leu Gly Asp Gly Ile Gly Tyr Val Leu 
             260                265                270
Phe Thr Leu Phe Ala Thr Tyr Ser Met Leu Pro Leu Pro Leu Thr Trp 
         275                280                285
Ala Ile Leu Ala Gly Leu Gly Thr Ser Leu Leu Gln Val Thr Leu Gln 
     290                295                300
Val Leu Ile Pro Arg Leu Ala Val Phe Ser Ile Asn Gln Val Leu Ala 
 305                310                315                320
Gln Val Val Leu Phe Met Cys Met Asn Thr Ala Gly Ile Phe Ile Ser 
                 325                330                335
Tyr Leu Ser Asp Arg Ala Gln Arg Gln Ala Phe Leu Glu Thr Arg Arg 
             340                345                350
Cys Val Glu Ala Arg Leu Arg Leu Glu Thr Glu Asn Gln Arg Gln Glu 
         355                360                365
Arg Leu Val Leu Ser Val Leu Pro Arg Phe Val Val Leu Glu Met Ile 
     370                375                380
Asn Asp Met Thr Asn Val Glu Asp Glu His Leu Gln His Gln Phe His 
 385                390                395                400
Arg Ile Tyr Ile His Arg Tyr Glu Asn Val Ser Ile Leu Phe Ala Asp 
                 405                410                415
Val Lys Gly Phe Thr Asn Leu Ser Thr Thr Leu Ser Ala Gln Glu Leu 
             420                425                430
Val Arg Met Leu Asn Glu Leu Phe Ala Arg Phe Asp Arg Leu Ala His 
         435                440                445
Glu His His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys 
     450                455                460
Val Ser Gly Leu Pro Glu Pro Arg Gln Asp His Ala His Cys Cys Val 
 465                470                475                480
Glu Met Gly Leu Ser Met Ile Lys Thr Ile Arg Phe Val Arg Ser Arg 
                 485                490                495
Thr Lys His Asp Val Asp Met Arg Ile Gly Ile His Ser Gly Ser Val 
             500                505                510
Leu Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser 
         515                520                525
Trp Asp Val Asp Ile Ala Asn Lys Leu Glu Ser Gly Gly Ile Pro Gly 
     530                535                540
Arg Ile His Ile Ser Lys Ala Thr Leu Asp Cys Leu Ser Gly Asp Tyr 
 545                550                555                560
Asn Val Glu Glu Gly His Gly Lys Glu Arg Asn Glu Phe Leu Arg Lys 
                 565                570                575
His Asn Ile Glu Thr Tyr Leu Ile Lys Gln Pro Glu Glu Ser Leu Leu 
             580                585                590
Ser Leu Pro Glu Asp Ile Val Lys Glu Ser Val Ser Cys Ser Asp Arg 
         595                600                605
Arg Asn Ser Gly Ala Thr Phe Thr Glu Gly Ser Trp Ser Pro Glu Leu 
     610                615                620
Pro Phe Asp Asn Ile Val Gly Lys Gln Asn Thr Leu Ala Ala Leu Thr 
 625                630                635                640
Arg Asn Ser Ile Asn Leu Leu Pro Asn His Leu Ala Gln Ala Leu His 
                 645                650                655
Val Gln Ser Gly Pro Glu Glu Ile Asn Lys Arg Ile Glu His Thr Ile 
             660                665                670
Asp Leu Arg Ser Gly Asp Lys Leu Arg Arg Glu His Ile Lys Pro Phe 
         675                680                685
Ser Leu Met Phe Lys Asp Ser Ser Leu Glu His Lys Tyr Ser Gln Met 
     690                695                700
Arg Asp Glu Val Phe Lys Ser Asn Leu Val Cys Ala Phe Ile Val Leu 
 705                710                715                720
Leu Phe Ile Thr Ala Ile Gln Ser Leu Leu Pro Ser Ser Arg Leu Met 
                 725                730                735
Pro Met Thr Ile Gln Phe Ser Ile Leu Ile Met Leu His Ser Ala Leu 
             740                745                750
Val Leu Ile Thr Thr Ala Glu Asp Tyr Lys Cys Leu Pro Leu Ile Leu 
         755                760                765
Arg Lys Thr Cys Cys Trp Ile Asn Glu Thr Tyr Leu Ala Arg Asn Val 
     770                775                780
Ile Ile Phe Ala Ser Ile Leu Ile Asn Phe Leu Gly Ala Val Ile Asn 
 785                790                795                800
Ile Leu Trp Cys Asp Phe Asp Lys Ser Ile Pro Leu Lys Asn Leu Thr 
                 805                810                815
Phe Asn Ser Ser Ala Val Phe Thr Asp Ile Cys Ser Tyr Pro Glu Tyr 
             820                825                830
Phe Val Phe Thr Gly Val Leu Ala Met Val Thr Cys Ala Val Phe Leu 
         835                840                845
Arg Leu Asn Ser Val Leu Lys Leu Ala Val Leu Leu Ile Met Ile Ala 
     850                855                860
Ile Tyr Ala Leu Leu Thr Glu Thr Ile Tyr Ala Gly Leu Phe Leu Ser 
 865                870                875                880
Tyr Asp Asn Leu Asn His Ser Gly Glu Asp Phe Leu Gly Thr Lys Glu 
                 885                890                895
Ala Ser Leu Leu Leu Met Ala Met Phe Leu Leu Ala Val Phe Tyr His 
             900                905                910
Gly Gln Gln Leu Glu Tyr Thr Ala Arg Leu Asp Phe Leu Trp Arg Val 
         915                920                925
Gln Ala Lys Glu Glu Ile Asn Glu Met Lys Asp Leu Arg Glu His Asn 
     930                935                940
Glu Asn Met Leu Arg Asn Ile Leu Pro Gly His Val Ala Arg His Phe 
 945                950                955                960
Leu Glu Lys Asp Arg Asp Asn Glu Glu Leu Tyr Ser Gln Ser Tyr Asp 
                 965                970                975
Ala Val Gly Val Met Phe Ala Ser Ile Pro Gly Phe Ala Asp Phe Tyr 
             980                985                990
Ser Gln Thr Glu Met Asn Asn Gln Gly Val Glu Cys Leu Arg Leu Leu 
         995                1000                1005
Asn Glu Ile Ile Ala Asp Phe Asp Glu Leu Leu Gly Glu Asp Arg Phe 
     1010                1015                1020
Gln Asp Ile Glu Lys Ile Lys Thr Ile Gly Ser Thr Tyr Met Ala Val 
 1025                1030                1035                1040
Ser Gly Leu Ser Pro Glu Lys Gln Gln Cys Glu Asp Lys Trp Gly His 
                 1045                1050                1055
Leu Cys Ala Leu Ala Asp Phe Ser Leu Ala Leu Thr Glu Ser Ile Gln 
             1060                1065                1070
Glu Ile Asn Lys His Ser Phe Asn Asn Phe Glu Leu Arg Ile Gly Ile 
         1075                1080                1085
Ser His Gly Ser Val Val Ala Gly Val Ile Gly Ala Lys Lys Pro Gln 
     1090                1095                1100
Tyr Asp Ile Trp Gly Lys Thr Val Asn Leu Ala Ser Arg Met Asp Ser 
 1105                1110                1115                1120
Thr Gly Val Ser Gly Arg Ile Gln Val Pro Glu Glu Thr Tyr Leu Ile 
                 1125                1130                1135
Leu Lys Asp Gln Gly Phe Ala Phe Asp Tyr Arg Gly Glu Ile Tyr Val 
             1140                1145                1150
Lys Gly Ile Ser Glu Gln Glu Gly Lys Ile Lys Thr Tyr Phe Leu Leu 
         1155                1160                1165
Gly Arg Val Gln Pro Asn Pro Phe Ile Leu Pro Pro Arg Arg Leu Pro 
     1170                1175                1180
Gly Gln Tyr Ser Leu Ala Ala Val Val Leu Gly Leu Val Gln Ser Leu 
 1185                1190                1195                1200
Asn Arg Gln Arg Gln Lys Gln Leu Leu Asn Glu Asn Ser Asn Ser Gly 
                 1205                1210                1215
Ile Ile Lys Ser His Tyr Asn Arg Arg Thr Leu Leu Thr Pro Ser Gly 
             1220                1225                1230
Pro Glu Pro Gly Ala Gln Ala Glu Gly Thr Asp Lys Ser Asp Leu Pro 
         1235                1240                1245



<210> 3106
<211> 2118
<212> DNA
<213> Homo sapiens
<308> M83533
<400> 3106

ctgaggaag  ataatatcg  aacttactt  attaagcag  ctgaggaca  tctgctgtc  60
ttgcctgaa  atatcgtca  ggagtcagt  agctcctca  accggagaa  cagtggggc  120
acattcact  aaggatcct  gagccctga  ctgcccttt  ataatatcg  ggggaaaca  180
aatactctg  ctgccctaa  aagaaattc  ataaatctg  ttccaaacc  tcttgcaca  240
gctttgcat  tccagtctg  gcctgagga  attaacaag  gaatagaac  taccatcga  300
ttgcggagt  gcgataaat  gagaagaga  catatcaag  cattctcac  gatgtttaa  360
gactccagc  tggagcaca  gtattctca  atgagggat  aagtgttca  gtcaaactt  420
gtctgtgca  ttatcgttc  tctatttat  acggcaata  aaagtttgc  tccttcttc  480
agagtgatg  caatgacca  ccagttctc  attctgatt  tgctgcact  ggctctggt  540
ctcatcacc  cagcagagg  ttataaatg  ttgcccctc  tcctccgga  aacttgctg  600
tggattaat  agacctatt  ggcccggaa  gtcatcatc  ttgcatcca  tttgattaa  660
ttcctgggt  ccatcttaa  tatcctgtg  tgtgatttt  acaagtcga  acccttgaa  720
aacctgact  tcaattcct  agctgtgtt  acagatatc  gctcctacc  agagtactt  780
gtcttcacg  gggtgttgg  catggtgac  tgtgcagtt  tcctccggc  gaactccgt  840
ctgaagctg  cagtgctgc  gatcatgat  gccatctat  ccctgctca  tgagaccgt  900
tacgcaggc  tctttctgc  ttatgacaa  ctcaaccac  gtggagaag  tttcctggg  960
accaaggag  tatcactgc  actgatggc  atgttcctc  tggctgtgt  ctaccatgg  1020
cagcagctg  agtacacag  ccgcctgga  ttcctttgg  gagtacagg  caaagagga  1080
atcaatgag  tgaaggagc  gagggaaca  aatgagaac  tgctccgga  tatcttacc  1140
agccatgtg  cccgccatt  cctagagaa  gaccgagac  atgaggagc  gtattctca  1200
tcctatgat  ctgttgggg  gatgtttgc  tccatccca  gatttgcgg  cttttactc  1260
cagactgaa  tgaataacc  gggagtgga  tgcctgcgc  tgctcaatg  gatcattgc  1320
gacttcgat  agttgcttg  tgaagaccg  tttcaagac  ttgaaaaga  taagaccat  1380
ggcagcacc  acatggccg  gtcaggcct  tcacctgaa  aacagcaat  tgaagacaa  1440
tggggacat  tgtgtgctc  ggctgactt  tcactcgcc  tgacagaaa  catacagga  1500
atcaacaag  attcattca  caattttga  ctccggatt  gcatcagcc  cggctcagt  1560
gtagctggc  ttatcggcg  taagaaacc  cagtatgac  tttggggca  aactgtgaa  1620
ctggcaagc  gaatggaca  cacgggggt  agtggccgg  tccaagtcc  agaggagac  1680
tatctcatc  tgaaggacc  gggctttgc  tttgattac  gaggggaga  ctatgtgaa  1740
ggtatcagt  aacaggaag  aaaaatcaa  acgtacttt  ttctgggaa  agtccaacc  1800
aacccattc  tcttgcccc  aagaagact  cctgggcag  actccctgg  cgcggttgt  1860
ctgggactt  tccagtccc  caataggca  aggcagaag  agctactca  tgagaacaa  1920
aacacagga  tcatcaagg  tcattacaa  cggcggact  tgttgtcac  cagcggcac  1980
gagcctgga  cccaggctg  aggcaccga  aaatctgat  tgccataaa  gcattttct  2040
tctgttttt  ttttttttt  tatttcttt  atatataaa  taaatatac  aataaaaag  2100
tttaatttt  tttagaac  2118



<210> 3107
<211> 1251
<212> PRT
<213> Homo sapiens
<308> P40145
<400> 3107

Met Glu Leu Ser Asp Val Arg Cys Leu Thr Gly Ser Glu Glu Leu Tyr 
  1               5                  10                  15
Thr Ile His Pro Thr Pro Pro Ala Gly Asp Gly Arg Ser Ala Ser Arg 
             20                  25                  30
Pro Gln Arg Leu Leu Trp Gln Thr Ala Val Arg His Ile Thr Glu Gln 
         35                  40                  45
Arg Phe Ile His Gly His Arg Gly Gly Ser Gly Ser Gly Ser Gly Gly 
     50                  55                  60
Ser Gly Lys Ala Ser Asp Pro Ala Gly Gly Gly Pro Asn His His Ala 
 65                  70                  75                  80
Pro Gln Leu Ser Gly Asp Ser Ala Leu Pro Leu Tyr Ser Leu Gly Pro 
                 85                  90                  95
Gly Glu Arg Ala His Ser Thr Cys Gly Thr Lys Val Phe Pro Glu Arg 
             100                105                110
Ser Gly Ser Gly Ser Ala Ser Gly Ser Gly Gly Gly Gly Asp Leu Gly 
         115                120                125
Phe Leu His Leu Asp Cys Ala Pro Ser Asn Ser Asp Phe Phe Leu Asn 
     130                135                140
Gly Gly Tyr Ser Tyr Arg Gly Val Ile Phe Pro Thr Leu Arg Asn Ser 
 145                150                155                160
Phe Lys Ser Arg Asp Leu Glu Arg Leu Tyr Gln Arg Tyr Phe Leu Gly 
                 165                170                175
Gln Arg Arg Lys Ser Glu Val Val Met Asn Val Leu Asp Val Leu Thr 
             180                185                190
Lys Leu Thr Leu Leu Val Leu His Leu Ser Leu Ala Ser Ala Pro Met 
         195                200                205
Asp Pro Leu Lys Gly Ile Leu Leu Gly Phe Phe Thr Gly Ile Glu Val 
     210                215                220
Val Ile Cys Ala Leu Val Val Val Arg Lys Asp Thr Thr Ser His Thr 
 225                230                235                240
Tyr Leu Gln Tyr Ser Gly Val Val Thr Trp Val Ala Met Thr Thr Gln 
                 245                250                255
Ile Leu Ala Ala Gly Leu Gly Tyr Gly Leu Leu Gly Asp Gly Ile Gly 
             260                265                270
Tyr Val Leu Phe Thr Leu Phe Ala Thr Tyr Ser Met Leu Pro Leu Pro 
         275                280                285
Leu Thr Trp Ala Ile Leu Ala Gly Leu Gly Thr Ser Leu Leu Gln Val 
     290                295                300
Ile Leu Gln Val Val Ile Pro Arg Leu Ala Val Ile Ser Ile Asn Gln 
 305                310                315                320
Val Val Ala Gln Ala Val Leu Phe Met Cys Met Asn Thr Ala Gly Ile 
                 325                330                335
Phe Ile Ser Tyr Leu Ser Asp Arg Ala Gln Arg Gln Ala Phe Leu Glu 
             340                345                350
Thr Arg Arg Cys Val Glu Ala Arg Leu Arg Leu Glu Thr Glu Asn Gln 
         355                360                365
Arg Gln Glu Arg Leu Val Leu Ser Val Leu Pro Arg Phe Val Val Leu 
     370                375                380
Glu Met Ile Asn Asp Met Thr Asn Val Glu Asp Glu His Leu Gln His 
 385                390                395                400
Gln Phe His Arg Ile Tyr Ile His Arg Tyr Glu Asn Val Ser Ile Leu 
                 405                410                415
Phe Ala Asp Val Lys Gly Phe Thr Asn Leu Ser Thr Thr Leu Ser Ala 
             420                425                430
Gln Glu Leu Val Arg Met Leu Asn Glu Leu Phe Ala Arg Phe Asp Arg 
         435                440                445
Leu Ala His Glu His His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys 
     450                455                460
Tyr Tyr Cys Val Ser Gly Leu Pro Glu Pro Arg Gln Asp His Ala His 
 465                470                475                480
Cys Cys Val Glu Met Gly Leu Ser Met Ile Lys Thr Ile Arg Tyr Val 
                 485                490                495
Arg Ser Arg Thr Lys His Asp Val Asp Met Arg Ile Gly Ile His Ser 
             500                505                510
Gly Ser Val Leu Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp 
         515                520                525
Val Trp Ser Trp Asp Val Asp Ile Ala Asn Lys Leu Glu Ser Gly Gly 
     530                535                540
Ile Pro Gly Arg Ile His Ile Ser Lys Ala Thr Leu Asp Cys Leu Asn 
 545                550                555                560
Gly Asp Tyr Asn Val Glu Glu Gly His Gly Lys Glu Arg Asn Glu Phe 
                 565                570                575
Leu Arg Lys His Asn Ile Glu Thr Tyr Leu Ile Lys Gln Pro Glu Asp 
             580                585                590
Ser Leu Leu Ser Leu Pro Glu Asp Ile Val Lys Glu Ser Val Ser Ser 
         595                600                605
Ser Asp Arg Arg Asn Ser Gly Ala Thr Phe Thr Glu Gly Ser Trp Ser 
     610                615                620
Pro Glu Leu Pro Phe Asp Asn Ile Val Gly Lys Gln Asn Thr Leu Ala 
 625                630                635                640
Ala Leu Thr Arg Asn Ser Ile Asn Leu Leu Pro Asn His Leu Ala Gln 
                 645                650                655
Ala Leu His Val Gln Ser Gly Pro Glu Glu Ile Asn Lys Arg Ile Glu 
             660                665                670
His Thr Ile Asp Leu Arg Ser Gly Asp Lys Leu Arg Arg Glu His Ile 
         675                680                685
Lys Pro Phe Ser Leu Met Phe Lys Asp Ser Ser Leu Glu His Lys Tyr 
     690                695                700
Ser Gln Met Arg Asp Glu Val Phe Lys Ser Asn Leu Val Cys Ala Phe 
 705                710                715                720
Ile Val Leu Leu Phe Ile Thr Ala Ile Gln Ser Leu Leu Pro Ser Ser 
                 725                730                735
Arg Val Met Pro Met Thr Ile Gln Phe Ser Ile Leu Ile Met Leu His 
             740                745                750
Ser Ala Leu Val Leu Ile Thr Thr Ala Glu Asp Tyr Lys Cys Leu Pro 
         755                760                765
Leu Ile Leu Arg Lys Thr Cys Cys Trp Ile Asn Glu Thr Tyr Leu Ala 
     770                775                780
Arg Asn Val Ile Ile Phe Ala Ser Ile Leu Ile Asn Phe Leu Gly Ala 
 785                790                795                800
Ile Leu Asn Ile Leu Trp Cys Asp Phe Asp Lys Ser Ile Pro Leu Lys 
                 805                810                815
Asn Leu Thr Phe Asn Ser Ser Ala Val Phe Thr Asp Ile Cys Ser Tyr 
             820                825                830
Pro Glu Tyr Phe Val Phe Thr Gly Val Leu Ala Met Val Thr Cys Ala 
         835                840                845
Val Phe Leu Arg Leu Asn Ser Val Leu Lys Leu Ala Val Leu Leu Ile 
     850                855                860
Met Ile Ala Ile Tyr Ala Leu Leu Thr Glu Thr Val Tyr Ala Gly Leu 
 865                870                875                880
Phe Leu Arg Tyr Asp Asn Leu Asn His Ser Gly Glu Asp Phe Leu Gly 
                 885                890                895
Thr Lys Glu Val Ser Leu Leu Leu Met Ala Met Phe Leu Leu Ala Val 
             900                905                910
Phe Tyr His Gly Gln Gln Leu Glu Tyr Thr Ala Arg Leu Asp Phe Leu 
         915                920                925
Trp Arg Val Gln Ala Lys Glu Glu Ile Asn Glu Met Lys Glu Leu Arg 
     930                935                940
Glu His Asn Glu Asn Met Leu Arg Asn Ile Leu Pro Ser His Val Ala 
 945                950                955                960
Arg His Phe Leu Glu Lys Asp Arg Asp Asn Glu Glu Leu Tyr Ser Gln 
                 965                970                975
Ser Tyr Asp Ala Val Gly Val Met Phe Ala Ser Ile Pro Gly Phe Ala 
             980                985                990
Asp Phe Tyr Ser Gln Thr Glu Met Asn Asn Gln Gly Val Glu Cys Leu 
         995                1000                1005
Arg Leu Leu Asn Glu Ile Ile Ala Asp Phe Asp Glu Leu Leu Gly Glu 
     1010                1015                1020
Asp Arg Phe Gln Asp Ile Glu Lys Ile Lys Thr Ile Gly Ser Thr Tyr 
 1025                1030                1035                1040
Met Ala Val Ser Gly Leu Ser Pro Glu Lys Gln Gln Cys Glu Asp Lys 
                 1045                1050                1055
Trp Gly His Leu Cys Ala Leu Ala Asp Phe Ser Leu Ala Leu Thr Glu 
             1060                1065                1070
Ser Ile Gln Glu Ile Asn Lys His Ser Phe Asn Asn Phe Glu Leu Arg 
         1075                1080                1085
Ile Gly Ile Ser His Gly Ser Val Val Ala Gly Val Ile Gly Ala Lys 
     1090                1095                1100
Lys Pro Gln Tyr Asp Ile Trp Gly Lys Thr Val Asn Leu Ala Ser Arg 
 1105                1110                1115                1120
Met Asp Ser Thr Gly Val Ser Gly Arg Ile Gln Val Pro Glu Glu Thr 
                 1125                1130                1135
Tyr Leu Ile Leu Lys Asp Gln Gly Phe Ala Phe Asp Tyr Arg Gly Glu 
             1140                1145                1150
Ile Tyr Val Lys Gly Ile Ser Glu Gln Glu Gly Lys Ile Lys Thr Tyr 
         1155                1160                1165
Phe Leu Leu Gly Arg Val Gln Pro Asn Pro Phe Ile Leu Pro Pro Arg 
     1170                1175                1180
Arg Leu Pro Gly Gln Tyr Ser Leu Ala Ala Val Val Leu Gly Leu Val 
 1185                1190                1195                1200
Gln Ser Leu Asn Arg Gln Arg Gln Lys Gln Leu Leu Asn Glu Asn Asn 
                 1205                1210                1215
Asn Thr Gly Ile Ile Lys Gly His Tyr Asn Arg Arg Thr Leu Leu Ser 
             1220                1225                1230
Pro Ser Gly Thr Glu Pro Gly Ala Gln Ala Glu Gly Thr Asp Lys Ser 
         1235                1240                1245
Asp Leu Pro 
     1250



<210> 3108
<211> 13553
<212> DNA
<213> Rattus norvegicus
<308> L27075
<400> 3108

gatcatcct  cctgaggct  ctgaatgct  aatacctga  tcccttccc  cagctgttc  60
ccatccgtg  gtggggacc  tttaggggg  ctttgaatg  ccctttcat  ggagttgca  120
gtacagata  tctgcatat  agatattta  attatattt  taacagtat  acagtagca  180
aattatagt  ataaagtag  aacaaaata  ttttatggt  gaaggttgc  acaacttga  240
tattaaggg  cacagtatt  ggtaggttg  gaacactgc  ttactacat  ctgctgaag  300
ttctttttc  ttctattgt  tttgtttgt  cgtttgttt  ttttttctg  gtgtagccc  360
ggtggtcct  gaacttggt  tgtagacca  gctggcctt  aactcacag  gatccacct  420
gctctggct  gcaagtgct  gaactaaag  tatgtgcca  catgctgga  taaaggtta  480
tcttttcta  ccaaaggga  aaccaaatt  atagagctc  acctgccta  aaaaaagtt  540
ttagtgtgt  catgtaggg  ggcacagta  tacagtgta  gtgtgtgga  gtctgagga  600
aattttgtg  agccgtttt  ctttaattg  ctatatgtg  gtttagcca  ggaactctc  660
tctttttgc  tagtaagtc  tttacccac  gagccattt  tctgggaca  tccactggt  720
attcacatt  actagtttt  taactagcc  gtgaagacc  gctagtccc  agggttcat  780
ttgttattc  agcatttgg  aagctgagg  aggagaata  acatttgaa  ttgttctca  840
tttatacaa  gagtttaca  acaacctgg  ctacatatt  ccctgtctc  aacagaaaa  900
taaatgacc  taaaagctc  gatttctgt  ctccagggc  tgaatttga  caacttcat  960
gaagacatt  acttaggga  aagtgatcc  tcacagaga  ttgggtagg  tctaggcct  1020
tctctcaac  tcaggagca  ggggcacta  aaactgtta  ttctaaaga  taagtatga  1080
ggaagggac  aaaaaaatg  catcatcaa  gagcacacg  tggtcaagc  tgggtgtaa  1140
aagttcagc  agcctttgg  ggagggctt  ggagtgggg  aggggggct  gggaaaagt  1200
tttgcccag  agagtgttg  aacattgtt  cagggagct  ttgacccag  gtttttgcc  1260
gggcatagc  atgccacgc  gattctctg  actctgggc  gatgcatca  ctgagccga  1320
tagaggatg  ttctggcct  cttcctaga  ctggaaaat  gtttgtttc  gggaccgtc  1380
gggaagaca  actgggact  aggtacaag  aaaagaggc  ttcactcca  ggaagcagt  1440
aatcggagt  ctgatttcc  ggacgttct  attttatat  ttctgctcc  caagtcggg  1500
acctgttag  ctgggtgct  cacttttgg  tttggaaaa  atgttctac  tctcatatg  1560
aacagaaaa  aagaggaag  tgttcattg  tttcagtgt  ttagtttga  ttgtgggag  1620
gagcaagag  ttggacagg  atggcccca  tgctaggtt  taatctcag  taaatgatc  1680
gctccgccc  gatccgcgc  caggtgagc  cgtaagagg  ctcgcgttg  aactggcgt  1740
cttctggcc  cactagttt  cctcttcct  ctatctatg  tctacgtcg  gcagtctga  1800
tgtgtagcg  ggtcatgta  tctgattct  gtaaattct  tggggtggg  ttcaggagc  1860
gagaggcgc  acgtgtgaa  ggaaagcag  cgtagcttt  caaagcagg  ctaccgcac  1920
ggtttggtg  ggcgactta  aaacgccag  gataagaac  tcagttgct  ccaggggag  1980
gagggaggg  acgccaggt  ccgggagaa  tgctactgc  ttttgggcc  acaaccccc  2040
cccacagct  cccaatcca  cagctggcc  gcccagccc  tgaagcgat  aggccacag  2100
ccccagcct  gtaggttct  ctcctagag  tgccccgcc  atctcccca  cctaggccg  2160
ccacggccc  tcccacttc  aagactaca  gtcccgtca  ccccgggtc  ggcatgagg  2220
cggggccac  cagcagcga  tggggagga  cctagagct  aggctaggg  acgcgtgtg  2280
ccaatcgcc  ggctgcatg  cctgtgagc  gatgggggg  ggggaggag  ccgcttggg  2340
cgggacaaa  gccggatcc  cggcagctg  aggcggctg  agcgatccg  ggagttggg  2400
taagctggt  cttacggac  gagagccac  ctcgggctt  ctcgaagag  tgagtactg  2460
aatcgtagg  gcgggtgcg  ccccctagt  cccactaag  ttcctgctt  cctccccca  2520
cccggaacc  cctccgggc  cgctggctg  aagatcccg  gcgctccct  cacctgctc  2580
gaagttttg  gcgggtctc  gctttatag  agtcttcgc  ccagccgcg  gccgcatgt  2640
tacactgcc  ccccaccct  agtcttttt  tagttcctg  gagtttgca  attgcttgc  2700
accgacctt  cttctcctc  ctcctccgg  ttgcctttg  gtgtcctgc  tcttctcag  2760
tccacccag  accagctct  gagtctctt  gggtttttt  ggacacttt  ttgggcccc  2820
ttcgggttc  ctaccggat  ccggggcgg  tagtagaga  ggcggtggc  actctcccc  2880
cgccggccg  tcacaaggc  gactcaagc  ggcccgtcc  cttagttct  tggtgaatc  2940
cttaagctc  atgtcgaag  ggagcgagc  ggccctgac  acgcggggt  gtgctgctt  3000
agagtgcct  aggccttgc  gcgaggact  gactccgga  cggcggcgc  ggttgggct  3060
tccctgcta  ggagctccc  accggtgta  cccccaaac  acagatggt  agagtgctc  3120
ggagtctgg  tgagacaag  tcctagggt  tgtgtatat  tgttcgtgc  cgcgcgcgt  3180
tgtgcaaaa  atgctacct  tccctcctg  caggcctga  agaggtcgg  ttcccaaag  3240
ctggtgctt  ctccagtct  gaagttctg  catgagggg  tccctcctg  tataatttt  3300
gaaaggaca  cataaggga  tttagtctg  cagcccacc  tgtctgtcc  cgctttaac  3360
ttgctcagt  ttttgggtt  ctttaatat  gagagataa  ttcccggga  ggatcattt  3420
cacctctta  aaagctgct  aaacatccc  ccggaggtt  gggggcgaa  gaggccttg  3480
agacagagt  gctgctctt  ttaaatctc  atttaggca  tgtctgctg  agcagagaa  3540
tctcaagag  attttgccc  gttcctttg  tatagggat  gcttgcttg  cgtgccctt  3600
ctccccccc  tcccagccc  taaagtgag  gtgttttgt  caccctaag  aacatcctc  3660
gtgggtccc  gaggagctt  ctttttttt  tttttggtt  tttttttcg  agctgggga  3720
cgaacccag  gccttgtgc  tcctaggta  gcgctctac  actgagcta  atcccagcc  3780
ctgaggagc  ttcttaaaa  gcagtcttc  ttcattctc  tttcctctg  gacttgctc  3840
tggggctct  tgagtgaat  cagtcctgg  tcactcact  tagaaaata  ccctttcaa  3900
tcaaaagcc  ccctttctt  gagagagac  gagagagag  gaatgtgag  gtgtgtgtt  3960
atatatgta  gtgcataga  gcatgccca  gttggattc  taggcatgg  ttcccatga  4020
gagtttgca  gttgttacc  ggtagcatt  tgatcagca  ctgagaaag  ctttggggg  4080
gtgtgcagg  ggtctccga  cccagattc  gatgtcctt  gtctcactg  ccctaacga  4140
agaagtttc  atgagtttg  gtgtgtgca  acttccctc  ggttttcca  gctttttag  4200
ttctgaaag  aattatgag  ccacaagga  ccattgctc  agagagcag  gaatcgatg  4260
ctgaagttt  gattgatct  cactgaggc  tccctggat  gatgagcta  actgctgag  4320
agccaggcc  ttcctccag  tagtctatg  gccctttgt  tggcctaag  cacagtact  4380
tggtggcac  tcttgtttt  gtaaactgg  aaattgttc  tgtatcgtc  ccctgttat  4440
ttgtctcct  acagaagac  tccttctgc  taaccccgc  ctaagatcc  agacctaag  4500
aaattgtga  ttccttcat  tgctaaggt  gtccttttt  cttcatctt  cacttagtt  4560
ggtcttggg  ctcttttgg  aggtactac  tcctgggga  tgttgtcag  ttcctgtca  4620
ctgtcttta  gagtaggct  ggcctaggg  cttcctttc  cctgcagtg  gtgatcctg  4680
ttgttgaag  tgtacgagt  gctggaagt  gtcagtgtc  cccccctcc  ctttctgat  4740
aaggtgccc  ggcttcatt  tgtttggga  gtgggtagg  gtgggtgtg  ccattcgat  4800
tcaggacca  tttttctgg  ctgagtcga  aaggttggg  aatgtaagt  gagtgggtg  4860
gggtggagg  ctctggggc  gtggggctg  ttgggatat  tcagtcaga  acaaatgaa  4920
gaggaatta  aagccatcc  aggagaagc  cctttccag  tacccactt  gaaccaggt  4980
ccaagctga  tgtgcccat  gtggtgaat  agagacaga  ggtggcggc  cagccagga  5040
tagcatctg  agcctctcc  gcgtggcct  ttgcaggga  ttcagtgtg  ccctgtgac  5100
cttggcttt  ctgggctag  agagaacac  agccttcct  gatgtgtca  cctgccagc  5160
ccttaactc  ccctcctta  gtgtacttg  ctttctctc  tgaacaaat  caacagctt  5220
cactttgtc  ctttgggag  ggcaggggc  acttgtcta  atctaggca  gcacttggc  5280
taataatgg  tttcgttct  catctcatc  cagtgttct  cacaagcag  tctggggag  5340
gagggtgtg  ctgcaaggt  gtgggcagg  aggatgaaa  aatatgcct  agagattct  5400
tggagtcga  gggggccag  cttgggaga  atggccttt  tgttgggtt  cagtagctg  5460
ttcctagag  ctcatttgg  agagtgtta  gacccaagt  ctaactggt  agtcaggct  5520
cttgggcaa  ttcattccc  cccgctgaa  ttttgattc  tggtagaag  aatgggatt  5580
tgaatctta  tggacttga  gcgctcacg  gagatttag  taatctctt  cagggctgg  5640
gagcaaacc  agggcctta  gtgtgttgg  ctagcactc  accaatgag  ttcatttgc  5700
gctcctaag  ggagtttct  tacacgtta  caaagacag  ttgtgcctt  tccccagtt  5760
tggcttagt  gaggaatga  tattacaga  tggtcccca  agagacctc  gttttgctt  5820
gagggtttt  ctccacact  acagctaag  tgactcaat  ggtggatga  atgatccgt  5880
ggtcatagt  tcctgccct  ggactgcta  gtacttgga  gtgggagtc  atcctagta  5940
gaacgagct  tgaggtaac  tcctttcct  cctcccatc  caccagggc  tgtactcta  6000
tagggcaca  gggatatat  tgagtcagc  tgggagtgg  aagaaacct  gggaggaaa  6060
aaggccagc  gtgttctaa  aggtcatag  acataaaga  tagttcagt  tgtctgggc  6120
caccttcga  aacagtatt  acatttgga  ctggctctt  gagttccta  cttcccctt  6180
gatctgaat  tttgctctg  actgaaggt  gttgtggcc  gctactttg  ccagaggga  6240
tagagacaa  gttaagggg  ataagagac  aggttaagg  taagccaag  ggaattgca  6300
ttttttttt  ttgttgttg  ttgttctcc  ttccccttc  cctccctcc  cctccttgg  6360
tcccttctt  ctttccttc  tctctttct  tctcttttt  agaccagat  tcatatggc  6420
taggctggc  ttgactctg  gatccttgc  cctctacct  ccaggtgag  ggaattatg  6480
gaagacact  ctgaatctg  caccacctt  atcgttttt  aaatttctt  acctccagg  6540
ctaaatctg  gctgctgac  gtgaagctg  ttgggccac  ccttccatc  cctcctgtc  6600
gggctgcct  ccctttttc  tcgttttga  aaaagtcaa  atctagttt  attgtctgg  6660
ggcagctgg  aatagatcc  acctgttgg  gggaagatt  tgccttggc  tttcttccc  6720
aactgacca  ccgttcccc  tcgtcgtcc  cttgcaggt  aaccaggtc  ctctgcagc  6780
atgtcagcc  aggcaattt  agagcagac  ggcaaagaa  tcctttaca  gtacatctg  6840
accacctca  ccatccaga  ccggttcaa  tatgcccgg  ttactcccg  cacagactg  6900
gcccatctc  tgcaggacc  cccctggct  cttagccag  taagccctt  ttttcagct  6960
aggctctga  gaggagaaa  cctttgatt  gtcggaggt  tcccaagga  ttccatgat  7020
gcagattcc  ctgtgtctg  agctggctg  gcagggtct  gccttgact  tgggccctt  7080
ctttggaac  agacagact  gtacccaga  cacacctcc  tttatgaac  gcgtggcct  7140
gggcgaatc  atttcactt  ccttgagtt  ggttcccca  ctgtcaaat  gggttgaca  7200
tttatgagc  ataaggatt  gcaggaaca  ccaggaagc  tttactgtg  tgtccagca  7260
ttggtagaa  ctcagttaa  aaaaaaaat  tgcctggtg  ggtggtgcc  ttaatcaca  7320
cacttggga  gcagaggca  gaggatctc  gtgagtttg  gaccagcct  gtgtacaaa  7380
tgtccagga  tattacaca  agaaaccct  tcttggaaa  cccccctcc  ggctcctcc  7440
ccacccaaa  aaggcttat  cctacctcc  ttccccaaa  tggaacatc  caggacatt  7500
aagaagtgg  accttcagg  tagagagat  gctcagtgg  taagatcga  taatcttct  7560
gtagaggac  tgggtttgg  tctagtttc  acgttgcag  ttacaacca  gggtaactc  7620
ggttccagg  gagctgatg  cctctcctg  atacatgta  gcaaagaac  cctacacat  7680
agaatgaat  aatatgggt  cggtcccca  ctccgaaaa  aaaagaacc  aaaaaaaaa  7740
aaaaaaaaa  aatgaatga  taaagaaat  ggaccttgt  ctttgtgaa  atggctgat  7800
tctgagcat  gaggagatc  gcctggagt  gacgatccc  ccatagcat  tttggggtg  7860
cttcgggaa  ccctagact  ctttggcgg  cctagacaa  gccttatgg  gtttcgttt  7920
ttcctttct  aggcagctg  gatggtagt  aatttcctg  ctgcctgtc  cctgatggt  7980
aagagattt  gctggggta  tcaaggaaa  tttccgggg  aggaaagtg  ccctagagg  8040
taaatgtct  gctagatct  gaagcgggg  gatcaaagc  atacaattt  actgctaca  8100
ccccgtttc  ttccccaac  ccttccatt  cagagcttg  tagtcaagc  ggaccagct  8160
atcaaacgt  gaggaaagc  tggtctagt  ggggtcaac  tctctctgg  tggagtcaa  8220
tcctggctg  aacctcgac  gggacatga  gccaccgtg  gtcctggtg  ggggtgggg  8280
ggggtcagg  tggtaacaa  cagcatggt  acctctaga  caaccaacc  atggctcat  8340
acctaacca  tcacatagc  acagagaaa  agatggcgt  cacactgcc  tggctgcag  8400
ccagtcttg  cggtgagaa  atcagtcca  tgatagtgt  ttagataag  tgcactgcg  8460
ttgtaagcc  agaacagtt  ggaagctag  agctgtgac  accagcatg  agatagggc  8520
cgtacttac  ctgagaact  cctgctctc  agtttccaa  ttcagttgt  tgagtttgg  8580
atgacgtgc  taccaggag  atgggagta  accgagatg  aaaggggag  cacatcatt  8640
ttaggcaaa  aagatacgc  ggtgggaga  ccatgggtg  agacagtta  taatgctga  8700
gacttaatt  agttctccc  cgtccgcga  tcctctcag  tatgaggat  agagctgag  8760
tgaaatgtg  cttaggagg  ttggggatt  agctcagtg  tagagcgct  gcttagcaa  8820
tgcaaggcc  tgggttcag  ccccagctc  gaaaaaaaa  aaaaagaaa  gtggcttag  8880
taggctaag  tgtgctctg  actgtttct  ctctttcac  gtcttcaag  ggggtgggt  8940
tgaatcttg  cctagccta  gaaggatgc  tttctatct  cttggcaca  aatcccgca  9000
atactggtg  ttgtctggg  taggcatgg  cagagaaga  ctgtttttt  ttttcctat  9060
gctgccctg  gaggtggca  tacccattt  cctccatgt  gggcttcct  aaagcagct  9120
ctactgttt  tttccggtc  ttgtgggta  agacagatc  ttgaagttg  gtccaggaa  9180
ggagagatc  gacctctgg  ttctcaggc  cctggggag  gagtggcag  gctgggtac  9240
gaacagtgc  cccagggag  aagcacatc  tgctctcct  cctgcaaac  gatgggagg  9300
agatgtcac  gacatctga  cttggcagc  gtgtcagac  tggctggag  ggctcatta  9360
ctctgatgg  tcactgtct  gtccctgac  cagcagtga  gcacggcag  cggggggca  9420
gtgggggga  tggggatga  gcctgtctc  cctttcctg  cgccaggga  ccactcaag  9480
tgattagct  tgcaggccg  ctgtcttca  ccaggaaac  caggaggaa  aagtttacc  9540
aatcagcct  gggctctct  ctctcccac  cctcaaggc  tagatgcat  tcctcaggc  9600
gggtcacta  gtcttcctc  gggcaaagt  gtgtgccgt  accatcata  ccaagttcc  9660
atctccctt  ttgactgcc  gggctaggg  gattgatca  tgggcaagg  gcttgtcac  9720
aggcctggt  acttgtgtt  gatccttgg  atccataag  tggagggag  gaaccatct  9780
gagttaccc  cacatcccc  ctccttgac  tgacattcg  atgttcctg  cctcctccc  9840
aaacataag  aaaaatatt  acgcaaaga  gggatcttc  aagaactcc  taagttcat  9900
cgggacccc  ttgtcctga  ttgtggaca  gtcactttg  cagatgtgg  ggtagtgct  9960
gggccttgc  ttcgtgaag  atgtaccac  catctaagc  gcatctccc  caatttctc  10020
ttaggtcgg  aaggccaaa  gcttcctca  gaactttct  attgagccc  tcgtccccc  10080
cagtcaggt  tgtgaggca  tgccaaatt  gatcttctt  ctccttcag  tttctgatt  10140
tcctccaaa  atgttgaaa  gagaggtta  ggtgccaag  ggagaagcc  agggcacaa  10200
ccaagggca  cagggtctc  aaagctcca  ctgaggcct  gaggaaatt  tgagcaagg  10260
gtccagaga  gaaggaagg  ttggtttgc  gcagagcag  tagagcagg  aacagggac  10320
tcctgttgt  ggggtcagg  cttgagggc  ggacccctt  ccaagatgg  acccagttg  10380
ggaagttga  gcctgtctt  tgcttgtcg  ctaggagaa  gtagcacgc  gatcgtggg  10440
tgaatactt  gtgttagga  ttagaaatg  gaccacagg  cttgggttc  actcctggg  10500
gaagccctc  gaccccttg  cagttgagc  cccttacca  gctctctgc  tgctctgtg  10560
ccttgaaag  tggaggagt  ctacgtgtg  atctatgct  cccgggaag  agactacgt  10620
ctgttccac  atgaagggg  tgtggatgt  ggcgatgtg  acaccaaag  ccagaagct  10680
cttgtgggt  tggacgaga  actgaacgc  gaagacatt  agagacacc  gttggtcca  10740
gcccccgaa  acaagaaag  gttgagttc  gagagggac  gtgtgggca  agccggggg  10800
gggacaaga  gtccagtgt  acttcaggg  acataggag  gagaaagca  agtggaaca  10860
ctggcgggc  tagctctgt  ttgaggaag  tagccactt  tgtggggag  ctgctgcct  10920
gcaatcagt  tgcagcatg  cagtctcat  cctcacctc  tgcccctgt  tgtctgtct  10980
gtgctccct  tgtctctga  cttgacagc  tctttccac  tctgtgtga  gagtgacag  11040
cagggagca  ggctggcag  ggacagtgg  ggccaaagg  tcaggcgtg  agtggggct  11100
aactgtcag  cagtgagcc  gctgtgtgt  ggtgacggg  tgggaatgg  agctgggtg  11160
ctcgtcctg  actgactga  taactggcc  tctttccct  tcccttcta  aatcctggc  11220
agcttcatc  ccggcctat  caatttcta  gaagatctt  acttcacct  ccttgagat  11280
aaccccctt  gtaacatgc  ttgtttgct  ggacgggat  gggatgggg  gctgccccc  11340
tgcctacag  aactctggc  ctggtgcca  aaggcagta  aaaacttct  tgggtaccc  11400
gggtgtccc  ataagggtg  tctccagtg  cacctccgg  ttctaagca  ccgggactg  11460
aacttattc  taccataac  aactgcagc  tctttctct  gccctaatt  gtcctgctc  11520
ggggaatcc  ggctttgga  tgtctatgg  gttgtctct  cctgccagt  aggctcccc  11580
ggctctggt  tgatcctcc  ggtacctgg  ggcctctct  ttgggtatt  gtcaatcat  11640
tactacccc  aacaccaag  agagctggc  gtaggctct  aagctgtga  ggaggcaga  11700
ggcctggca  aatctggct  ggcctctca  ggcaaagtc  atgaagaag  gaattacca  11760
atttcagct  agaatgcag  tcctctaat  ggccagatg  ctgtgtgct  acttaatta  11820
ctaaatggc  ggggacaaa  atggatgct  aggtggagg  attgcagat  aatgtgttg  11880
cgggggccc  gagcactct  gggtacctt  cacagacac  gagacttcc  cagctagac  11940
acagaagcc  gggatgtgc  caccttctg  tagtagagg  ttatgaatg  cgtgtgatg  12000
tgtgctgct  cttgggttt  aacccaaaa  ctagaccaa  agggctctt  gtcgttggt  12060
tgggttttg  tgttgtttt  agttagggc  aagtttagt  cacactgtc  tcaaaccca  12120
tcactatag  cgaggatga  cttgaactt  tgtcctgat  cccctgtgc  tccgtaccc  12180
gcttccaca  ttgttattt  agttaattt  aaatggtta  agattattt  attgatgtc  12240
ttgtgagga  gtgtgccta  gttggccag  aaagtatgt  tgacggctg  agttacagt  12300
ttgagctgc  tcacgtggg  tctggcact  gaactcatg  tctgtagag  agcagcaag  12360
tctctttaa  tatctctca  cccctagtt  gtattttct  atatatttg  ttatttccc  12420
ccctgtgtc  cgtgtgcgc  cgtgaagca  agaggacag  ctatgagag  ccggtctct  12480
ctcctacca  atggcctgg  ggcaaatac  tttctgcac  gatcaatct  acagtcttt  12540
atttattct  taatatatt  tttggtata  gggattgaa  ctatggcct  tcccatgta  12600
ttttttttt  ttttttttt  tggttcttt  tttcggagc  ggggaccga  cccagggcc  12660
tgcgcttcc  aggtaagcg  tctaccact  agctaaatc  ccagcccct  ccatgtact  12720
ttaacccca  aaaacaggg  gtttttgtt  gttcgtttg  ttgtttgtt  ttcatgtca  12780
ggctatggg  aggccagtg  ttgagtatt  aaagcaggg  gaatggcat  cttttgaag  12840
tgtcccaaa  cttgctatg  taactaaca  gtctcgttt  acctgtttt  aggtcagtg  12900
gtggggact  ttctgacag  attttcctt  tgctggcga  gtatcacaa  acgtggtta  12960
tcggtgtgt  tgagagggc  ctggcggga  tctggaggg  tggttggag  gttggtgtc  13020
gacactgtt  tacttttct  ctagtggtg  ccaaagatg  tgtctacat  cttgacctg  13080
cggccaagg  ggacgccac  gctgactac  tctgcaaag  caagtgggg  gatatagag  13140
tccctcccc  ctttgggcg  gaggcatac  cagaggtaa  gcagctttg  gaaggagat  13200
gagggtgat  gggcctagg  gacagtgac  aatcctaga  gatcatttg  tcccctttt  13260
ggctctgta  ttggcagga  aggaaagac  gagagccat  taattttct  aaaacccca  13320
tgaggttgg  ggtcggggt  gaaatcagc  aaggtcctg  atcctggcc  gaaaccctt  13380
tagacagcg  tctcagtca  cctccccgg  cttctgact  gatttgctg  tccttgatt  13440
ttccaagtg  ctcttccca  ccctgatgg  aaggaaggt  cttctcctg  ccactggct  13500
agaatttta  ttgctgctt  ccatcccat  ctctgagag  tcctcccag  agg  13553



<210> 3109
<211> 2622
<212> DNA
<213> Rattus norvegicus
<308> L27112
<400> 3109

tgtatgaca  tacatcatg  gtgacagta  aagcgatgg  cagttttac  gtgtgcaag  60
ggcagactc  actttcact  ttctaaaac  ttaccagca  ttgaaacca  ttggctctg  120
agcccaagg  attgtttgt  ctgcttttg  tacagttct  ggaataaat  ttgctgtca  180
gaagttaag  cgtcctttt  agaaccaaa  gcatgcaaa  agagcctac  gtgaacttg  240
cctcctaaa  tgtgtcaat  ataaaaata  aattagctt  ttaaatgtg  tcacaccac  300
aaaaacgct  gaagaattc  aagatgtgt  cttggttat  gagttaatg  acgctaact  360
atgtcaggt  attcatatg  agctggacc  tgaaagaat  tcatacctc  tctaccaga  420
gctttgtgg  attaagcac  tgcattcag  tggcataat  catagggat  tgaagccta  480
caacattgt  gtaaaatca  actgtactc  caagatcct  gactttggc  tggcacgga  540
agcctgtac  aactttatg  tgactccct  tgtggtaac  cgctactat  gggctccag  600
agtcatcct  ggcatgggc  acaaggaga  tgttgatat  tggtcagtg  gttgcatca  660
gggagagct  gtgaaaggt  gtgtgatat  ccaaggtac  gaccatatt  atcaatgga  720
taaagttat  gaacagcta  gaacaccat  cgcagagtt  atgaagaaa  ttcagccaa  780
tgtaaggaa  tatgtggaa  acagaccaa  gtaccctgg  atcaaattt  aagagctct  840
tccagattg  atatttccg  cagaatccg  acgagacaa  ataaaaaca  gtcaagcca  900
agatctgtt  tcgaaaatg  tagtgattg  tccggacaa  cggatctct  tggacgaag  960
cttgcgcca  ccgtatatt  ctgtttggt  tgaccccgc  gaagcagaa  cgccaccac  1020
tcaaattta  gatgcccag  tggaagaaa  agagcatgc  attgaagag  ggaaagaac  1080
aatttacaa  gaagtgatg  actgggaag  aagaagcaa  aatggggtg  aagaccagc  1140
ttcagatgc  gcagtaagc  gcaaggcta  tccttctca  tcgtcatcc  tcaatgaca  1200
ctcatccat  tccactgag  acaccctgg  ctcagacac  gacagcagt  tcgatgcct  1260
aaccggacc  ctggaaggc  gccgatgaa  cctcgcaga  ggcgcactt  tctgtgaag  1320
actctggct  ccatggccc  gagcacatg  gagctggtg  aacaaatca  gaagctcca  1380
gttctgcat  taagaaaca  gacgccttg  ccccactca  ttccagtag  attgcctgc  1440
tagactgta  catgaggca  acgatgtct  gagaaaaag  acaaaccac  ctgttagaa  1500
ttttgttca  gatcattca  gtgagcaat  agaatagcc  agttctttt  aagtcgtgt  1560
gtgtccttg  tgacagatc  tgtgtaact  tggggactc  tatgcatgt  accacaaat  1620
cttgcttga  cttgcccat  tagcacttt  ggaatcagt  tttaaatgc  aaataatct  1680
ccaggtagt  ctgcttcta  aataatctc  taatcctct  tagtaattt  gtgtctgtc  1740
acaaaaaaa  agattatgt  tgtatgaat  ggccactat  atattatca  attttaccc  1800
cttttatgg  atgatttat  ctgtctttt  tatttcaga  ggaatataa  taaatttat  1860
taataaata  aactacagc  tttcttaaa  ttgtgatgt  ttaggctga  aattaccac  1920
gctttatat  gacactctg  gtcctttaa  ctgcccact  tgggaaact  tacgtacag  1980
tttctgcat  acaaagttc  aagttgtat  tcactctgc  taacgactt  tgtcacctt  2040
aatcctgac  acacatttc  tttttcttg  tcctctgaa  ttggatcta  aatccctca  2100
agaacttca  cttctttat  acaaagcac  ccatctcag  agaatgaat  ggcagattc  2160
tgagccccg  tgcctaatg  agagctgac  gggtggctt  cccagaacg  tgggtgggt  2220
catccttcc  tgagcccac  catcctttg  tcccctctc  ttatttaag  tgaaaggtg  2280
ttgggtctc  tagcctttc  ttttgtagc  ttgcctaac  tgtctttct  actgacaga  2340
gccaccacg  ccagccaga  cacatggtc  cttaggaga  cgggcttac  taccatgca  2400
gtttgctgc  gtccttttc  attttgtgg  ggcatttcc  ttttctaag  gaattcctc  2460
gatgttcta  aaacattca  aagaacgca  aagaaatat  ctagagaat  gggggttca  2520
tcttgaata  tttctgatt  aaaactgct  acctgaaat  gatactttc  gatcctgat  2580
ttgtaaatt  ctcgagatt  ggtaagatg  tgagttctc  gt  2622



<210> 3110
<211> 423
<212> PRT
<213> Rattus norvegicus
<308> P49186
<400> 3110

Met Ser Asp Ser Lys Ser Asp Gly Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Lys Ala 
     370                375                380
Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser Thr 
 385                390                395                400
Glu His Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser Thr 
                 405                410                415
Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 3111
<211> 1782
<212> DNA
<213> Homo sapiens
<308> L31951
<400> 3111

gggcgggcg  gggatctga  acttgccca  ccttcggga  attgcagga  gctgcatca  60
gagcgacag  aaatgtgac  gtcagtttt  tagtgtgca  gtggcagac  caaccttca  120
tgtcctaaa  cgttaccag  agctgaaac  aattggctc  ggggcccaa  ggattgttt  180
tgctgcatt  gatacagtt  ttgggataa  tgttgcagt  aagaaacta  gccgtcctt  240
tcagaacca  actcatgca  agagagctt  tcgtgaact  gtcctctta  aatgtgtca  300
tcataaaaa  ataattagt  tgttaaatg  gtttacacc  caaaaaact  tagaagaat  360
tcaagatgt  tatttggtt  tggaattaa  ggatgctaa  ttatgtcag  ttattcaca  420
ggagctgga  catgaaaga  tgtcctacc  tctttacca  atgctttgt  gtattaaac  480
tctgcattc  gctggtata  ttcatagag  tttgaagcc  agcaacatt  ttgtgaaat  540
agactgcac  ctgaagatc  ttgactttg  cctggcccg  acagcgtgc  ctaacttca  600
gatgacccc  tacgtggtg  cacggtact  ccgggcgcc  gaagtcatc  tgggtatgg  660
ctacaaaga  aacgttgat  tctggtcag  gggttgcat  atgggagag  tggtgaaag  720
ttgtgtgat  ttccaaggc  ctgaccata  tgatcagtg  aataaagtt  ttgagcagc  780
gggaacacc  tcagcagag  tcatgaaga  acttcagcc  actgtgagg  attatgtcg  840
aaacagacc  aagtatcct  gaatcaaat  tgaagaact  tttccagat  ggatattcc  900
atcagaatc  gagcgagac  aaataaaaa  aagtcaagc  agagatctg  tatcaaaaa  960
gttagtgat  gatcctgac  agcggatct  tgtagacga  gctctgcgt  acccataca  1020
cactgtttg  tatgacccc  ccgaagcag  agccccacc  cctcaaatt  atgatgccc  1080
gttggaaga  agagaacat  caattgaag  atggaaaga  ctaatttac  aagaagtca  1140
ggattggga  gaaagaagc  agaatggtg  tgtaaaaga  cagccttca  atgcagcag  1200
aagtagcaa  gccactcct  ctcagtctt  atcgatcaa  gacatttca  ccatgtcca  1260
tgagcagac  ctggcctca  acacagaca  cagtcttga  gcctcgacg  gaccccttg  1320
aggctgtcg  tgataggtt  gaaatagca  acctgtcag  attgaagga  ctctcacct  1380
cgtgggcct  aaatgcttg  gagttgatg  aaccaaata  aaaaactcc  tgttctgca  1440
gtaagaaac  caatgcctt  ccctattca  acctgatag  attgcctgc  tagatgata  1500
aatgaggca  aatatgtct  aagaaaaaa  ttgcaagcc  cacttctag  gattttgtt  1560
aagatcatt  caggtgagc  gttagagta  gtgaatttg  ttcaaattg  actagtgac  1620
gtttctcat  atctgtaac  gttgagatg  atgtgcatg  gaccacaaa  gcttgcttg  1680
acttgccca  ctagcactt  ggaaatcag  atttaaatg  caaataatc  tccaggtag  1740
gctgcttct  aagttatct  ttaatcctc  taagtaatt  gg  1782



<210> 3112
<211> 424
<212> PRT
<213> Homo sapiens
<308> P45984
<400> 3112

Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Ser Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Asn 
     370                375                380
Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser 
 385                390                395                400
Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser 
                 405                410                415
Thr Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 3113
<211> 2622
<212> DNA
<213> Rattus norvegicus
<308> L27112
<400> 3113

tgtatgaca  tacatcatg  gtgacagta  aagcgatgg  cagttttac  gtgtgcaag  60
ggcagactc  actttcact  ttctaaaac  ttaccagca  ttgaaacca  ttggctctg  120
agcccaagg  attgtttgt  ctgcttttg  tacagttct  ggaataaat  ttgctgtca  180
gaagttaag  cgtcctttt  agaaccaaa  gcatgcaaa  agagcctac  gtgaacttg  240
cctcctaaa  tgtgtcaat  ataaaaata  aattagctt  ttaaatgtg  tcacaccac  300
aaaaacgct  gaagaattc  aagatgtgt  cttggttat  gagttaatg  acgctaact  360
atgtcaggt  attcatatg  agctggacc  tgaaagaat  tcatacctc  tctaccaga  420
gctttgtgg  attaagcac  tgcattcag  tggcataat  catagggat  tgaagccta  480
caacattgt  gtaaaatca  actgtactc  caagatcct  gactttggc  tggcacgga  540
agcctgtac  aactttatg  tgactccct  tgtggtaac  cgctactat  gggctccag  600
agtcatcct  ggcatgggc  acaaggaga  tgttgatat  tggtcagtg  gttgcatca  660
gggagagct  gtgaaaggt  gtgtgatat  ccaaggtac  gaccatatt  atcaatgga  720
taaagttat  gaacagcta  gaacaccat  cgcagagtt  atgaagaaa  ttcagccaa  780
tgtaaggaa  tatgtggaa  acagaccaa  gtaccctgg  atcaaattt  aagagctct  840
tccagattg  atatttccg  cagaatccg  acgagacaa  ataaaaaca  gtcaagcca  900
agatctgtt  tcgaaaatg  tagtgattg  tccggacaa  cggatctct  tggacgaag  960
cttgcgcca  ccgtatatt  ctgtttggt  tgaccccgc  gaagcagaa  cgccaccac  1020
tcaaattta  gatgcccag  tggaagaaa  agagcatgc  attgaagag  ggaaagaac  1080
aatttacaa  gaagtgatg  actgggaag  aagaagcaa  aatggggtg  aagaccagc  1140
ttcagatgc  gcagtaagc  gcaaggcta  tccttctca  tcgtcatcc  tcaatgaca  1200
ctcatccat  tccactgag  acaccctgg  ctcagacac  gacagcagt  tcgatgcct  1260
aaccggacc  ctggaaggc  gccgatgaa  cctcgcaga  ggcgcactt  tctgtgaag  1320
actctggct  ccatggccc  gagcacatg  gagctggtg  aacaaatca  gaagctcca  1380
gttctgcat  taagaaaca  gacgccttg  ccccactca  ttccagtag  attgcctgc  1440
tagactgta  catgaggca  acgatgtct  gagaaaaag  acaaaccac  ctgttagaa  1500
ttttgttca  gatcattca  gtgagcaat  agaatagcc  agttctttt  aagtcgtgt  1560
gtgtccttg  tgacagatc  tgtgtaact  tggggactc  tatgcatgt  accacaaat  1620
cttgcttga  cttgcccat  tagcacttt  ggaatcagt  tttaaatgc  aaataatct  1680
ccaggtagt  ctgcttcta  aataatctc  taatcctct  tagtaattt  gtgtctgtc  1740
acaaaaaaa  agattatgt  tgtatgaat  ggccactat  atattatca  attttaccc  1800
cttttatgg  atgatttat  ctgtctttt  tatttcaga  ggaatataa  taaatttat  1860
taataaata  aactacagc  tttcttaaa  ttgtgatgt  ttaggctga  aattaccac  1920
gctttatat  gacactctg  gtcctttaa  ctgcccact  tgggaaact  tacgtacag  1980
tttctgcat  acaaagttc  aagttgtat  tcactctgc  taacgactt  tgtcacctt  2040
aatcctgac  acacatttc  tttttcttg  tcctctgaa  ttggatcta  aatccctca  2100
agaacttca  cttctttat  acaaagcac  ccatctcag  agaatgaat  ggcagattc  2160
tgagccccg  tgcctaatg  agagctgac  gggtggctt  cccagaacg  tgggtgggt  2220
catccttcc  tgagcccac  catcctttg  tcccctctc  ttatttaag  tgaaaggtg  2280
ttgggtctc  tagcctttc  ttttgtagc  ttgcctaac  tgtctttct  actgacaga  2340
gccaccacg  ccagccaga  cacatggtc  cttaggaga  cgggcttac  taccatgca  2400
gtttgctgc  gtccttttc  attttgtgg  ggcatttcc  ttttctaag  gaattcctc  2460
gatgttcta  aaacattca  aagaacgca  aagaaatat  ctagagaat  gggggttca  2520
tcttgaata  tttctgatt  aaaactgct  acctgaaat  gatactttc  gatcctgat  2580
ttgtaaatt  ctcgagatt  ggtaagatg  tgagttctc  gt  2622



<210> 3114
<211> 423
<212> PRT
<213> Rattus norvegicus
<308> P49186
<400> 3114

Met Ser Asp Ser Lys Ser Asp Gly Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Lys Ala 
     370                375                380
Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser Thr 
 385                390                395                400
Glu His Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser Thr 
                 405                410                415
Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 3115
<211> 1782
<212> DNA
<213> Homo sapiens
<308> L31951
<400> 3115

gggcgggcg  gggatctga  acttgccca  ccttcggga  attgcagga  gctgcatca  60
gagcgacag  aaatgtgac  gtcagtttt  tagtgtgca  gtggcagac  caaccttca  120
tgtcctaaa  cgttaccag  agctgaaac  aattggctc  ggggcccaa  ggattgttt  180
tgctgcatt  gatacagtt  ttgggataa  tgttgcagt  aagaaacta  gccgtcctt  240
tcagaacca  actcatgca  agagagctt  tcgtgaact  gtcctctta  aatgtgtca  300
tcataaaaa  ataattagt  tgttaaatg  gtttacacc  caaaaaact  tagaagaat  360
tcaagatgt  tatttggtt  tggaattaa  ggatgctaa  ttatgtcag  ttattcaca  420
ggagctgga  catgaaaga  tgtcctacc  tctttacca  atgctttgt  gtattaaac  480
tctgcattc  gctggtata  ttcatagag  tttgaagcc  agcaacatt  ttgtgaaat  540
agactgcac  ctgaagatc  ttgactttg  cctggcccg  acagcgtgc  ctaacttca  600
gatgacccc  tacgtggtg  cacggtact  ccgggcgcc  gaagtcatc  tgggtatgg  660
ctacaaaga  aacgttgat  tctggtcag  gggttgcat  atgggagag  tggtgaaag  720
ttgtgtgat  ttccaaggc  ctgaccata  tgatcagtg  aataaagtt  ttgagcagc  780
gggaacacc  tcagcagag  tcatgaaga  acttcagcc  actgtgagg  attatgtcg  840
aaacagacc  aagtatcct  gaatcaaat  tgaagaact  tttccagat  ggatattcc  900
atcagaatc  gagcgagac  aaataaaaa  aagtcaagc  agagatctg  tatcaaaaa  960
gttagtgat  gatcctgac  agcggatct  tgtagacga  gctctgcgt  acccataca  1020
cactgtttg  tatgacccc  ccgaagcag  agccccacc  cctcaaatt  atgatgccc  1080
gttggaaga  agagaacat  caattgaag  atggaaaga  ctaatttac  aagaagtca  1140
ggattggga  gaaagaagc  agaatggtg  tgtaaaaga  cagccttca  atgcagcag  1200
aagtagcaa  gccactcct  ctcagtctt  atcgatcaa  gacatttca  ccatgtcca  1260
tgagcagac  ctggcctca  acacagaca  cagtcttga  gcctcgacg  gaccccttg  1320
aggctgtcg  tgataggtt  gaaatagca  acctgtcag  attgaagga  ctctcacct  1380
cgtgggcct  aaatgcttg  gagttgatg  aaccaaata  aaaaactcc  tgttctgca  1440
gtaagaaac  caatgcctt  ccctattca  acctgatag  attgcctgc  tagatgata  1500
aatgaggca  aatatgtct  aagaaaaaa  ttgcaagcc  cacttctag  gattttgtt  1560
aagatcatt  caggtgagc  gttagagta  gtgaatttg  ttcaaattg  actagtgac  1620
gtttctcat  atctgtaac  gttgagatg  atgtgcatg  gaccacaaa  gcttgcttg  1680
acttgccca  ctagcactt  ggaaatcag  atttaaatg  caaataatc  tccaggtag  1740
gctgcttct  aagttatct  ttaatcctc  taagtaatt  gg  1782



<210> 3116
<211> 424
<212> PRT
<213> Homo sapiens
<308> P45984
<400> 3116

Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Ser Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Asn 
     370                375                380
Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser 
 385                390                395                400
Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser 
                 405                410                415
Thr Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 3117
<211> 573
<212> DNA
<213> Rattus norvegicus
<308> L27421
<400> 3117

atggggaaa  ccaacagca  gttgaagcc  gaagttgtg  aggagctga  cagaaaaac  60
tacttcact  aaaaagaag  acagcagtg  tacaagggt  tcattaagg  ctgccccag  120
gggcagctg  acgccgctg  cttccagaa  atctacaaa  agttcttcc  atttggaga  180
cccaccaag  tcgccacgt  tgttttcaa  gtcttcgac  agaacaagg  tggcaggat  240
gagttctcc  aattcatcc  ggctctatc  gtgacctca  gggggaccc  ggatgagaa  300
ttgaggtgg  ccttcaagc  ttatgactt  gataacgac  gctacatca  cagaaacga  360
atgctggac  tagtggatg  catttacca  atggtgggg  acaccgtgg  gctcccaga  420
gaagagaac  caccagaga  gagggtgga  cggatcttc  ccatgatgg  taagaacgc  480
gatgggaag  taactcttc  ggagttcca  gaaggctcc  aggccgacc  ctccattgt  540
caggcgctg  ccctctacg  cgggctggt  tag  573



<210> 3118
<211> 189
<212> PRT
<213> Rattus norvegicus
<308> P36610
<400> 3118

Gly Lys Ser Asn Ser Lys Leu Lys Pro Glu Val Val Glu Glu Leu Thr 
  1               5                  10                  15
Arg Lys Thr Tyr Phe Thr Glu Lys Glu Val Gln Gln Trp Tyr Lys Gly 
             20                  25                  30
Phe Ile Lys Asp Cys Pro Ser Gly Gln Leu Asp Ala Ala Gly Phe Gln 
         35                  40                  45
Lys Ile Tyr Lys Gln Phe Phe Pro Phe Gly Asp Pro Thr Lys Phe Ala 
     50                  55                  60
Thr Phe Val Phe Asn Val Phe Asp Glu Asn Lys Asp Gly Arg Ile Glu 
 65                  70                  75                  80
Phe Ser Glu Phe Ile Gln Ala Leu Ser Val Thr Ser Arg Gly Thr Leu 
                 85                  90                  95
Asp Glu Lys Leu Arg Trp Ala Phe Lys Leu Tyr Asp Leu Asp Asn Asp 
             100                105                110
Gly Tyr Ile Thr Arg Asn Glu Met Leu Asp Ile Val Asp Ala Ile Tyr 
         115                120                125
Gln Met Val Gly Asn Thr Val Glu Leu Pro Glu Glu Glu Asn Thr Pro 
     130                135                140
Glu Lys Arg Val Asp Arg Ile Phe Ala Met Met Asp Lys Asn Ala Asp 
 145                150                155                160
Gly Lys Leu Thr Leu Gln Glu Phe Gln Glu Gly Ser Lys Ala Asp Pro 
                 165                170                175
Ser Ile Val Gln Ala Leu Ser Leu Tyr Asp Gly Leu Val 
             180                185



<210> 3119
<211> 4341
<212> DNA
<213> Homo sapiens
<308> NM_014286
<400> 3119

ccggcccgg  ccgcccggc  cagccgctc  tgctgggcg  cccaaccgg  tccggcccg  60
gggggcggg  gccgcggcc  ccgaggatg  ggaaatcca  cagcaagtt  aagcccgaa  120
ttgtggagg  gctgaccag  aagacctac  ttaccgaga  ggaggtcca  cagtggtac  180
aaggcttca  caaggactg  cccagtggg  agctggatg  ggcaggctt  cagaagatc  240
acaagcaat  cttcccgtt  ggagacccc  ccaagtttg  cacatttgt  ttcaacgtc  300
ttgatgaaa  caaggacgg  cgaattgag  tctccgagt  catccaggc  ctgtcggtg  360
cctcacggg  aaccctgga  gagaagcta  ggtgggcct  caagctcta  gacttggac  420
atgatggct  catcaccag  aatgagatg  tggacattg  ggatgccat  taccagatg  480
tggggaata  cgtggagct  ccagaggag  agaacactc  tgagaagag  gtggaccgg  540
tctttgcca  gatggataa  aatgccgac  ggaagctga  cctgcagga  ttccaggag  600
ggtccaagg  agacccgtc  attgtgcag  cgctgtccc  ctacgacgg  ctggtatag  660
cccaggctg  agctggatg  ctgggaacc  ctcacctcc  tctgtgcca  gaggccacc  720
cagccctga  accaacccc  tgcgtccac  cagccttct  ccgcatcca  acacagccg  780
ctgcccttg  cccgggagg  cccggctct  ctctcccct  tcctgcacc  atcccccgc  840
tgaagccac  ggctccaat  gccagcaac  tctgcttgt  cggaaaacg  caacacgaa  900
tggaaaagg  tacagccct  tgcataaac  aaggacttg  ctgcctcgc  ggcagcctc  960
gttcctccc  ctctcttgc  cgtgtgctt  tgtttttta  tttgaacag  cgttttaaa  1020
gaaaaaaaa  caactacct  ctgtcctag  agacacaga  tgacagatg  ggtgaaggc  1080
tggggacct  agagaactc  gccttgccc  cgtccctcg  ccttcggca  ccggagagg  1140
tgtgggtgg  ccgagggtg  ctaggggtt  tgcctagtc  acgttattt  tcgtcccat  1200
ttttggcag  aaaaccacc  gcgtggcta  gatgattaa  tatgaggat  atgattttt  1260
ttgtgataa  agtattgtg  tttttgtgg  gaaagtgag  ttttttttt  atatacata  1320
ataattgat  tctttaatt  attggttgt  aactgttgc  gctgcctgg  gtgtcctca  1380
ctcccaggg  tgcgggccc  ccgtttaca  gtgcacgcc  tgacccacc  gcccacgcc  1440
acttgggag  atggtggcc  gcagcggcc  agaagccaa  aaaaatttt  tttttttca  1500
atactgtgc  tgatttttg  agaggggag  ggtggaaat  cctaaatgg  taatgcact  1560
ttccctcca  cccgaatgc  tcctgccaa  ccccttttc  ctgctgcct  tgtccccgc  1620
tccttgttc  cccctgggt  cgtaacatt  tttccgagg  tgaacaggg  acatcttta  1680
gtttctcaa  tcttgcttt  gtgtttgcc  cagcatgga  aacagggcg  ctaaggctg  1740
gagctggaa  aaggggcat  gggtaccca  gcagagtca  gagaggtgg  ctttgaagt  1800
agttagcag  aatcaaggg  acccccgcc  ccttgggct  gggagggga  ttcaagata  1860
ttcataact  tctcccgct  tgccttccc  ccttcctat  tgctttttc  agtaaactg  1920
atggtgtcc  tccctggcc  tctcttggc  caaaggctg  gagggaggg  aggagagaa  1980
agttccagg  aatcccatc  atatagtcc  tacacctgg  gctgcggcc  acatgtctt  2040
acggaggct  ccagcggtg  ctgccactg  ggcaggtgc  gccccagga  catcaccag  2100
aatgcgagg  caccctgga  cagaggtag  agcccaagg  ccggccctt  ctctttgat  2160
gtgggcagc  tcctgccct  tctgggtct  agttgcccc  tctgcagag  gaggaggcc  2220
gggctggtt  gtcttgaag  cccttttcc  tgccgacat  atgtcactc  aggcctggg  2280
ttcagtttc  tgtggctgg  gatgctgtg  ttaagtttg  ttgacccca  cagcccgag  2340
gactgtctg  gtcacagca  agcccctat  gcgtggctg  tggtgtgtg  ggtcagttc  2400
agcagatga  tgtgtcatg  ggcacacct  gtcccttcc  gcagcattt  ctggttccc  2460
ccagaccct  gagcgctct  tgggaccca  aaggagtcc  tgcacaggg  aggcttgag  2520
tgagaagcc  cttcccaga  tgtcagggc  aggcctggg  ctagaattc  tgctgctgc  2580
ttgcagagt  aacagccca  cagcccatg  tttagaggg  acactttgg  cctcggttc  2640
caccctcag  aagcaggcc  ccagcccga  gaaggcctc  gccgtagtg  cgttgccgt  2700
tggggctgc  tggctgttc  ccttggctg  agcattcag  caaccccag  gtcccccct  2760
aggcgttca  tggcagccc  ctaggactg  acgctggcc  cacggtaac  ccccctccc  2820
caccaacat  ctgcaggga  ggggtcagt  gttccacct  cacaggcca  tttgaaggg  2880
ggattcttt  aggcccctg  cagtcggct  cctgctcag  tgctggccc  ggcgacctg  2940
gactcagca  caacggctg  agtttctca  ctgggctct  acctggggt  tggggcagg  3000
aacgaacat  gtggctttg  gctgagagg  tgagggagg  ctttcccag  tcaaattac  3060
ttcctttgg  ctctgcctg  ggctcgatt  gcctctctg  tccaatggg  ctgacactg  3120
tgtacaacc  gacctgtgg  tgagggtgt  tgggcttaa  catgtggac  ccttcggtg  3180
gtctggcct  cctccatcg  cctgccctt  ggccttttg  tttgaagcc  caggtgtgg  3240
ttctggcct  agcagatgg  atgcttgcg  accgcagcc  agcatgccg  tgggcccac  3300
gcccgagcc  gcccagagc  gccggaagg  ccgcccttc  cggccctgg  ggggtgctg  3360
acactggcc  ttttcacta  agtttgcct  gcagggacc  atctctgcc  cctcctctc  3420
ccaggcctc  ggctgcagt  atgccgcag  atcctgagc  aggtgcctc  tgagcagcc  3480
gtgcgcctc  ccacagcgg  gtttgccac  caatgcggc  cgcttcaga  gctctgatg  3540
agagggcac  cccatagtc  ctctgcaga  cctcgcact  gggccaggg  aggcaccag  3600
cccaggcgg  cagtcggcc  cggcctgtc  tcttcctcg  agcgtctgc  cctcacttt  3660
tgttgatgg  gacttagga  aatgttccg  ttttccatg  tctaagcag  ccacgttta  3720
aataacatc  aggcaagcg  acgtgtcac  ctctgtact  acatctcct  ccctgaaat  3780
cttttcagt  tgacagccc  tttcctaga  aagtgcacc  ggggtttca  gaactttgt  3840
ttttttcgg  gggggttgg  ggggaggtc  ggatgcctg  gatcccttc  tggagaggc  3900
ggctgtctc  ggaaaaagc  tccattgcc  acccgccag  cggaaagtc  ccctgttcc  3960
agcgcggtt  cagcattta  ttttaaggg  gctaaggaa  cgcggcgcg  cccctggtg  4020
tggtaagcc  ccaacgcac  tgggggctg  aaccccacc  gacgggtgg  ccggaggga  4080
gctggagcg  ggaggcgag  agggggctg  gagtcctca  aggccctgg  ccaccacat  4140
tctggcagc  tttcccaga  acccctctg  taggccatc  ctggatagc  agtgaatta  4200
cttaagggc  ctgtgatgg  aagccttgc  cccctcttt  ttttttttt  tttaatatc  4260
gcggaataa  cccaatggt  aatttttga  tgaataaaa  gcttttgtt  aataaaaaa  4320
aaaaaaaaa  aaaaaaaaa  a  4341



<210> 3120
<211> 189
<212> PRT
<213> Homo sapiens
<308> P36610
<400> 3120

Gly Lys Ser Asn Ser Lys Leu Lys Pro Glu Val Val Glu Glu Leu Thr 
  1               5                  10                  15
Arg Lys Thr Tyr Phe Thr Glu Lys Glu Val Gln Gln Trp Tyr Lys Gly 
             20                  25                  30
Phe Ile Lys Asp Cys Pro Ser Gly Gln Leu Asp Ala Ala Gly Phe Gln 
         35                  40                  45
Lys Ile Tyr Lys Gln Phe Phe Pro Phe Gly Asp Pro Thr Lys Phe Ala 
     50                  55                  60
Thr Phe Val Phe Asn Val Phe Asp Glu Asn Lys Asp Gly Arg Ile Glu 
 65                  70                  75                  80
Phe Ser Glu Phe Ile Gln Ala Leu Ser Val Thr Ser Arg Gly Thr Leu 
                 85                  90                  95
Asp Glu Lys Leu Arg Trp Ala Phe Lys Leu Tyr Asp Leu Asp Asn Asp 
             100                105                110
Gly Tyr Ile Thr Arg Asn Glu Met Leu Asp Ile Val Asp Ala Ile Tyr 
         115                120                125
Gln Met Val Gly Asn Thr Val Glu Leu Pro Glu Glu Glu Asn Thr Pro 
     130                135                140
Glu Lys Arg Val Asp Arg Ile Phe Ala Met Met Asp Lys Asn Ala Asp 
 145                150                155                160
Gly Lys Leu Thr Leu Gln Glu Phe Gln Glu Gly Ser Lys Ala Asp Pro 
                 165                170                175
Ser Ile Val Gln Ala Leu Ser Leu Tyr Asp Gly Leu Val 
             180                185



<210> 3121
<211> 3185
<212> DNA
<213> Rattus norvegicus
<308> L27487
<400> 3121

gaattcgcg  ccgctgctc  tttcctggg  taagctatt  gagaaagaa  gtaacctaa  60
actaagtgc  ggcggggcg  ggtgatgta  caggaagct  tgatgtttc  cttctgctg  120
tgatcgctt  caatctgac  acactcccc  tctacccag  acaagccct  tcttcgcag  180
ggtgcactt  tgctttagg  ccggcgggc  ctgttgcct  gacctcacg  tgcctgcca  240
gaagctttt  gactcttcc  cacctcttc  ccgggaact  ttttctact  tctcagaaa  300
tcaaattcc  tcctgagac  attcacaca  aatttcctt  ggagccgtg  gcgggccct  360
tgatgatac  ccaacatct  gtgctacca  ctgtcaaaa  ctttggatg  tctaacact  420
aggtcatga  ccttgtaat  aagaaattc  cgaagacaa  attgagcat  attcaggag  480
aaatgtgat  tgagtctgg  gacaattgt  catgtatat  tttcttaag  tcttaaaaa  540
aaagagaaa  caaatccag  gttgtcggt  actgattga  agaagagaa  acaatattc  600
gacgattgc  tatgattga  aagaggtcc  gcggccgct  cccagcttg  acatatcgc  660
cacttcagt  ggactctaa  gatggataa  aagtgtaca  tatgttttc  gtttctctt  720
cttcttaat  tggctctca  cgcagcaga  tcggaagaa  gcgcgaacc  aacagactt  780
ggagtcact  ggaacaaga  catgacggc  cagtatgaa  gttaccaaa  gatcatgca  840
gatcccatt  aacaaggag  aggccttta  tgcaacaga  cctgggacg  atggctatg  900
tggaatgac  ttgcagcag  aaccgagtc  atgcagtac  gccctgatt  ctttcaaga  960
tttgatcct  cagagaagg  tacaaagat  tgtgaccaa  atggaaact  gttcagaca  1020
ccagatagt  acaggacat  gacaaacta  accttgtgt  acaacagca  gcatgagaa  1080
gagaagaca  cactgaatt  gttctacct  actataatt  gacatggat  atctattgc  1140
tctctgatc  tctcactca  catattttt  tatttcaag  gcctaagtt  ccaacggat  1200
acattgcat  aaaacctgt  cttttcatt  gtttgtaat  cgattgtga  aatcattca  1260
ctcacggca  tggccaata  ccaggcctt  gtggccaca  atcctgtga  ctgcaaggt  1320
tcccagttc  ttcatcttt  cctgatggg  tgtaactac  tttggatgc  ctgtgaagg  1380
atttacctg  acacactca  tgtggtggc  gtgtttgca  agaagcagc  cttgatgtg  1440
tattatttt  ttggctggg  gtttcctct  cttcctgcc  gcatccatg  catcgccag  1500
agcttgtat  acaatgaca  ctgctggat  agctcagac  ctcatctcc  ctacatcat  1560
catggtccc  tttgtgctg  tttactggt  aatctcttt  tcctattaa  tattgtacg  1620
gttctcatc  ccaagttga  agttacaca  caagcagaa  ccaatctct  catgaaagc  1680
gtaagagcc  ctctcatct  ggtaccact  cttggcatt  aatttgtgc  ttttccatg  1740
cggcctgaa  gaaaggttg  tgaggaggt  tatgactat  tcatgcaca  tctcatgca  1800
tatcagggt  ttttggtgt  tacaatttt  tgcttcttt  acggagagg  tcaagcaat  1860
ctgagaaga  attggaacc  gtataaaat  caatttggc  atggctttt  ccactctga  1920
gctctccgc  gcgcatcct  tacggtgtc  acaatcagc  atgtgcagg  gtacagcca  1980
gactgcccc  ctgaacact  aaatggaaa  agcatccag  atattgaaa  tgttgcctt  2040
aaaccagaa  aaatgtatg  tctagtgat  tgaaaatac  gaaatctca  ttgttttgt  2100
tcacttgaa  ctatgattt  atagtcgga  gatttaata  caaatgggt  tcttgaata  2160
catgaagaa  gccctcaaa  gaaatgaga  ttgtgtgga  aaatgttta  caaccctct  2220
tctatgggg  agaaaagcc  caattttta  tgttggcca  taaatactc  taccatagc  2280
gatttcaag  taccaacct  acatcaccg  atgtggaat  ggaaagaaa  taagcacaa  2340
caactcttg  gagctgaca  gcgtcgtca  acctgcaca  caccgcatg  tctcacaga  2400
ggacctgtg  acactcaca  ccgcactga  cagaactct  ctcctctgt  tgagaagat  2460
ttgctcagt  ttacagaca  gaaaggaaa  tttggtttt  gttataaaa  tcctcatcc  2520
ttgtcattt  atggtagtg  acggtttgt  cagaaacac  ttaaccctc  ttataactt  2580
tcctgtaga  gagacagag  ttgctatct  tgtcacctc  tgttccttt  tttaagaaa  2640
gcaactgag  agaattccc  tgggcttct  agttgctgc  acatatggt  gtatcctgt  2700
gcatatcca  tctgaatca  tagggagac  tattgatag  agctacaaa  actttgtca  2760
ctacctttt  gccctctaa  tcttgctgc  ggagtagga  gaaatcagt  ttcctgaat  2820
tgtaaatag  aactttggc  tttccattt  tactgtgta  ataagtgat  aaccatttt  2880
tatgaaggg  atcaatgaa  gatttattt  tatcttggg  atctgagag  gagagagag  2940
gagagagag  gagagagag  gagagagag  gagattgtt  tacaaatga  actgtaagt  3000
ctctgtcat  ttattttat  gtttcaaat  aaaacacaa  ctaagtaac  gttttaaag  3060
agatggata  tgcaacttt  tatgcgact  ggtgtctga  actgtgtct  ggctgattt  3120
ttttataga  aaaatggag  actgaattc  atatttggt  aatatttta  ggcggccgc  3180
aattc  3185



<210> 3122
<211> 464
<212> PRT
<213> Rattus norvegicus
<308> Q63118
<400> 3122

Met Met Asp Lys Lys Cys Thr Leu Cys Phe Leu Phe Leu Leu Leu Leu 
  1               5                  10                  15
Asn Met Ala Leu Ile Ala Ala Glu Ser Glu Glu Gly Ala Asn Gln Thr 
             20                  25                  30
Asp Leu Gly Val Thr Arg Asn Lys Ile Met Thr Ala Gln Tyr Glu Cys 
         35                  40                  45
Tyr Gln Lys Ile Met Gln Asp Pro Ile Gln Gln Gly Glu Gly Leu Tyr 
     50                  55                  60
Cys Asn Arg Thr Trp Asp Gly Trp Leu Cys Trp Asn Asp Val Ala Ala 
 65                  70                  75                  80
Gly Thr Glu Ser Met Gln Tyr Cys Pro Asp Tyr Phe Gln Asp Phe Asp 
                 85                  90                  95
Pro Ser Glu Lys Val Thr Lys Ile Cys Asp Gln Asp Gly Asn Trp Phe 
             100                105                110
Arg His Pro Asp Ser Asn Arg Thr Trp Thr Asn Tyr Thr Leu Cys Asn 
         115                120                125
Asn Ser Thr His Glu Lys Val Lys Thr Ala Leu Asn Leu Phe Tyr Leu 
     130                135                140
Thr Ile Ile Gly His Gly Leu Ser Ile Ala Ser Leu Ile Ile Ser Leu 
 145                150                155                160
Ile Ile Phe Phe Tyr Phe Lys Ser Leu Ser Cys Gln Arg Ile Thr Leu 
                 165                170                175
His Lys Asn Leu Phe Phe Ser Phe Val Cys Asn Ser Ile Val Thr Ile 
             180                185                190
Ile His Leu Thr Ala Val Ala Asn Asn Gln Ala Leu Val Ala Thr Asn 
         195                200                205
Pro Val Ser Cys Lys Val Ser Gln Phe Ile His Leu Tyr Leu Met Gly 
     210                215                220
Cys Asn Tyr Phe Trp Met Leu Cys Glu Gly Ile Tyr Leu His Thr Leu 
 225                230                235                240
Ile Val Val Ala Val Phe Ala Glu Lys Gln His Leu Met Trp Tyr Tyr 
                 245                250                255
Phe Leu Gly Trp Gly Phe Pro Leu Leu Pro Ala Cys Ile His Ala Ile 
             260                265                270
Ala Arg Ser Leu Tyr Tyr Asn Asp Asn Cys Trp Ile Ser Ser Asp Thr 
         275                280                285
His Leu Leu Tyr Ile Ile His Gly Pro Ile Cys Ala Ala Leu Leu Val 
     290                295                300
Asn Leu Phe Phe Leu Leu Asn Ile Val Arg Val Leu Ile Thr Lys Leu 
 305                310                315                320
Lys Val Thr His Gln Ala Glu Ser Asn Leu Tyr Met Lys Ala Val Arg 
                 325                330                335
Ala Thr Leu Ile Leu Val Pro Leu Leu Gly Ile Glu Phe Val Leu Phe 
             340                345                350
Pro Trp Arg Pro Glu Gly Lys Val Ala Glu Glu Val Tyr Asp Tyr Val 
         355                360                365
Met His Ile Leu Met His Tyr Gln Gly Leu Leu Val Ser Thr Ile Phe 
     370                375                380
Cys Phe Phe Asn Gly Glu Val Gln Ala Ile Leu Arg Arg Asn Trp Asn 
 385                390                395                400
Gln Tyr Lys Ile Gln Phe Gly Asn Gly Phe Ser His Ser Asp Ala Leu 
                 405                410                415
Arg Ser Ala Ser Tyr Thr Val Ser Thr Ile Ser Asp Val Gln Gly Tyr 
             420                425                430
Ser His Asp Cys Pro Thr Glu His Leu Asn Gly Lys Ser Ile Gln Asp 
         435                440                445
Ile Glu Asn Val Ala Leu Lys Pro Glu Lys Met Tyr Asp Leu Val Met 
     450                455                460



<210> 3123
<211> 2187
<212> DNA
<213> Homo sapiens
<308> U17473
<400> 3123

aattccgga  gaccatcaa  ctctgctaa  tgaatctca  cctaattgc  ggatcacat  60
gcaaagctt  cactctttc  caccttgct  gtgggtaaa  ctcttctgc  gaatctcag  120
aagtaaagt  ccatcctga  aatatttca  aaagaattt  cttaagagc  ggactgggt  180
ttgacccct  aatttaaga  attcttaaa  acaatgtca  atatgatcc  agagaaaat  240
tgatttgag  ctggagacc  attgtgcat  tcgtctaat  ataaaaacc  atactagcc  300
atagaaaac  atatttgaa  gattgctac  actaaaaag  aaactacta  aacttgaca  360
gactgctgc  aacttcaat  tgtcaacca  aacttgaca  ggttgctat  aaacaagat  420
gctacaact  ctagtttat  ttatacagc  tatttcatt  tggcttaat  atggagaaa  480
agtgtaccc  gtattttct  gttctcttg  cttttttta  gattcttgt  acagcagaa  540
tagaagaga  tcctgagga  tcaattcag  tgggagtta  tagaaataa  atcatgaca  600
ctcaatatg  atgttacca  aagattatg  aagacccca  tcaacaagc  gaaggcgtt  660
actgcaaca  aacctggga  ggatggctc  gctggaacg  tgttgcagc  ggaactgaa  720
caatgcagc  ctgccctga  tactttcag  actttgatc  atcagaaaa  gttacaaag  780
tctgtgacc  agatggaaa  tggtttaga  atccagcaa  caacagaac  tggacaaat  840
atacccagt  taatgttaa  acccacgag  aagtgaaga  tgcactaaa  ttgttttac  900
tgaccataa  tggacacgg  ttgtctatt  catcactgc  tatctcgct  ggcatattc  960
tttatttca  gagcctaag  tgccaaagg  ttaccttac  caaaaatct  ttcttctca  1020
ttgtttgta  ctctgttgt  acaatcatt  acctcactg  agtggccaa  aaccaggcc  1080
tagtagcca  aaatcctgt  agttgcaaa  tgtcccagt  cattcatct  tacctgatg  1140
gctgtaatt  cttttggat  ctctgtgaa  gcatttacc  acacacact  attgtggtg  1200
ccgtgtttg  agagaagca  catttaatg  ggtattatt  tcttggctg  ggatttcca  1260
tgattcctg  ttgtataca  gccattgct  gaagcttat  ttacaatga  aattgctgg  1320
tcagttctg  tacccatct  ctctacatt  tccatggcc  aatttgtgc  gctttactg  1380
tgaatcttt  tttcttgtt  aatattgta  gcgttctca  caccaagtt  aaagttaca  1440
accaagcgg  atccaatct  tacatgaaa  ctgtgagag  tactcttat  ttggtgcca  1500
tgcttggca  tgaatttgt  ctgattcca  ggcgacctg  aggaaagat  gcagaggag  1560
tatatgact  catcatgca  atccttatg  acttccagg  tcttttggt  tctaccatt  1620
tctgcttct  taatggaga  gttcaagca  ttctgagaa  aaactggaa  caatacaaa  1680
tccaatttg  aaacagctt  tccaactca  aagctcttc  tagtgcgtc  tacacagtg  1740
caacaatca  tgatggtcc  ggttatagt  atgactgtc  tagtgaaca  ttaaatgga  1800
aaagcatcc  tgatattga  aatgttctc  taaaaccag  aaatttata  aattgaaaa  1860
agaaggatg  ttgtctcac  gttttgtgc  tctcctaac  caaggactt  gacccatga  1920
tctgtagcc  gaagacttc  atattaaat  actttttga  tgtcataaa  aagagcctt  1980
acatgaaat  agtagtgtg  tgataagag  gtaacatcc  gctctatgt  ggaaaaaag  2040
aatcctggt  tgtaatgtt  gtcagtaaa  actcccact  tgcctgatg  gacgctact  2100
acctgacat  accaagtgt  gaattggag  aaagcacaa  caacttttc  gagctggtg  2160
aagccagtt  cagcacacc  ttgcatg  2187



<210> 3124
<211> 461
<212> PRT
<213> Homo sapiens
<308> Q16602
<400> 3124

Met Glu Lys Lys Cys Thr Leu Tyr Phe Leu Val Leu Leu Pro Phe Phe 
  1               5                  10                  15
Met Ile Leu Val Thr Ala Glu Leu Glu Glu Ser Pro Glu Asp Ser Ile 
             20                  25                  30
Gln Leu Gly Val Thr Arg Asn Lys Ile Met Thr Ala Gln Tyr Glu Cys 
         35                  40                  45
Tyr Gln Lys Ile Met Gln Asp Pro Ile Gln Gln Ala Glu Gly Val Tyr 
     50                  55                  60
Cys Asn Arg Thr Trp Asp Gly Trp Leu Cys Trp Asn Asp Val Ala Ala 
 65                  70                  75                  80
Gly Thr Glu Ser Met Gln Leu Cys Pro Asp Tyr Phe Gln Asp Phe Asp 
                 85                  90                  95
Pro Ser Glu Lys Val Thr Lys Ile Cys Asp Gln Asp Gly Asn Trp Phe 
             100                105                110
Arg His Pro Ala Ser Asn Arg Thr Trp Thr Asn Tyr Thr Gln Cys Asn 
         115                120                125
Val Asn Thr His Glu Lys Val Lys Thr Ala Leu Asn Leu Phe Tyr Leu 
     130                135                140
Thr Ile Ile Gly His Gly Leu Ser Ile Ala Ser Leu Leu Ile Ser Leu 
 145                150                155                160
Gly Ile Phe Phe Tyr Phe Lys Ser Leu Ser Cys Gln Arg Ile Thr Leu 
                 165                170                175
His Lys Asn Leu Phe Phe Ser Phe Val Cys Asn Ser Val Val Thr Ile 
             180                185                190
Ile His Leu Thr Ala Val Ala Asn Asn Gln Ala Leu Val Ala Thr Asn 
         195                200                205
Pro Val Ser Cys Lys Val Ser Gln Phe Ile His Leu Tyr Leu Met Gly 
     210                215                220
Cys Asn Tyr Phe Trp Met Leu Cys Glu Gly Ile Tyr Leu His Thr Leu 
 225                230                235                240
Ile Val Val Ala Val Phe Ala Glu Lys Gln His Leu Met Trp Tyr Tyr 
                 245                250                255
Phe Leu Gly Trp Gly Phe Pro Leu Ile Pro Ala Cys Ile His Ala Ile 
             260                265                270
Ala Arg Ser Leu Tyr Tyr Asn Asp Asn Cys Trp Ile Ser Ser Asp Thr 
         275                280                285
His Leu Leu Tyr Ile Ile His Gly Pro Ile Cys Ala Ala Leu Leu Val 
     290                295                300
Asn Leu Phe Phe Leu Leu Asn Ile Val Arg Val Leu Ile Thr Lys Leu 
 305                310                315                320
Lys Val Thr His Gln Ala Glu Ser Asn Leu Tyr Met Lys Ala Val Arg 
                 325                330                335
Ala Thr Leu Ile Leu Val Pro Leu Leu Gly Ile Glu Phe Val Leu Ile 
             340                345                350
Pro Trp Arg Pro Glu Gly Lys Ile Ala Glu Glu Val Tyr Asp Tyr Ile 
         355                360                365
Met His Ile Leu Met His Phe Gln Gly Leu Leu Val Ser Thr Ile Phe 
     370                375                380
Cys Phe Phe Asn Gly Glu Val Gln Ala Ile Leu Arg Arg Asn Trp Asn 
 385                390                395                400
Gln Tyr Lys Ile Gln Phe Gly Asn Ser Phe Ser Asn Ser Glu Ala Leu 
                 405                410                415
Arg Ser Ala Ser Tyr Thr Val Ser Thr Ile Ser Asp Gly Pro Gly Tyr 
             420                425                430
Ser His Asp Cys Pro Ser Glu His Leu Asn Gly Lys Ser Ile His Asp 
         435                440                445
Ile Glu Asn Val Leu Leu Lys Pro Glu Asn Leu Tyr Asn 
     450                455                460



<210> 3125
<211> 1910
<212> DNA
<213> Rattus norvegicus
<308> L27651
<400> 3125

gtccaaggg  ccatgtggt  agcagactg  accgtccta  ataccaaag  gggacacct  60
gtgggtggg  agcatgggc  tcgaagacc  gctggacaa  gtgggcggc  ttgggccct  120
ccaacttcg  aatctggtt  tgatggccc  gccccgaat  ctgctcccc  tgcactttc  180
cctgcccgt  ttcatggcc  ctgtgcctg  ccaccattg  gccctgccc  gtgcccctg  240
caacctcag  caccaggac  tatggctgg  agcccatct  ccccgggag  ctgacggca  300
ctttagctc  tgcctccga  ttgcctatc  ccagactgt  cccaatgtc  ctttgggga  360
agaggtgtc  aactctggg  agcctgagg  tgagcccct  acggtgccc  gctctcagg  420
ctgggagta  gaccgctca  aattctcct  caccattgc  actgagtgg  atcttgtgt  480
tcagcagag  ggactgaac  aaattacgt  cacctgctt  ttcattggt  tgctggtgg  540
agccgtggt  tatggatac  tgtctgaca  gtttggcag  cgccggctt  tgctggtgg  600
ctacgtgag  tccctggtg  tgggtctga  gtctgcagc  tccatcaac  acatcatgt  660
cgtagtcac  cgtacactc  ccggctcag  cctggctgg  ttcaccatc  ttgtgctcc  720
actggagtt  gagtggctg  atgtggagc  ccgcactgt  gccggggtc  tcagcaccg  780
cttctggtc  ggaggcgtg  tgctgctgg  actggtggg  tacctgatc  ggagctggc  840
ctggcttct  ctggctgcc  ccctgccgt  tgtcccagg  atcatcagc  tctggtggg  900
tcctgagtc  gcacggtgg  ttctaaccc  gggtcgtgt  gaggaggca  aaaaatact  960
gctgagctg  gccaagctc  atgggcggc  cgtgggtga  ggcagcctg  gccaggagg  1020
cctgaacaa  gtggtcacc  tggaaaggg  gttgcaaag  ccctcatac  tagacctgt  1080
ccgaacatc  cagctccga  atatctcac  gtgctgcat  atggtgtgg  ttggagtga  1140
cttttccta  tacggcctg  ctctggacg  gtctgggct  gggctgaac  tgtaccaga  1200
acagctgct  tttggggct  tggagctcc  ctccaaaat  atggtctac  tccttgtgc  1260
ccgtctggg  cgccgtctc  cggaggctg  gatgctgct  ggcgctgct  tgacctttg  1320
caccagcct  ctggtatcc  tggagacta  gtcatggat  actgctctg  tggtggtgg  1380
gaaagcttt  tctgaagct  cttttacta  ggcctacct  ttcacgtcc  agttgtacc  1440
tactgtgct  agacagaca  gattgggac  tactgcact  atgggcagg  taggggcct  1500
tctggcccg  ctggcggcc  tgctggatg  agtgtggct  ttgctgccc  aagttgctt  1560
cggggggat  gccctggtg  ctgcctgca  tgcactcct  ctgcctgag  cgaagaagg  1620
acagctgcc  gagaccatc  aggatgtgg  gaggaagag  acccaggag  aagatgtgt  1680
ggtccggga  tgagttgga  tagcgacag  tctccacag  agctgggca  agaaggcag  1740
ctcttgtga  tgggacatc  gactcctcc  cctaaggat  gagctgctc  tgatgccct  1800
tgcctgtgc  ctccagcag  agaacaact  cccgcagca  tgggccgct  ggattctgg  1860
ctcccctct  atggccggg  gcttctata  ataaagacg  ttgctcatgg  1910



<210> 3126
<211> 535
<212> PRT
<213> Rattus norvegicus
<308> AAA57157
<400> 3126

Met Gly Phe Glu Asp Leu Leu Asp Lys Val Gly Gly Phe Gly Pro Phe 
  1               5                  10                  15
Gln Leu Arg Asn Leu Val Leu Met Ala Leu Pro Arg Met Leu Leu Pro 
             20                  25                  30
Met His Phe Leu Leu Pro Val Phe Met Ala Ala Val Pro Ala His His 
         35                  40                  45
Cys Ala Leu Pro Gly Ala Pro Ala Asn Leu Ser His Gln Asp Leu Trp 
     50                  55                  60
Leu Glu Ala His Leu Pro Arg Glu Thr Asp Gly Ser Phe Ser Ser Cys 
 65                  70                  75                  80
Leu Arg Phe Ala Tyr Pro Gln Thr Val Pro Asn Val Thr Leu Gly Thr 
                 85                  90                  95
Glu Val Ser Asn Ser Gly Glu Pro Glu Gly Glu Pro Leu Thr Val Pro 
             100                105                110
Cys Ser Gln Gly Trp Glu Tyr Asp Arg Ser Glu Phe Ser Ser Thr Ile 
         115                120                125
Ala Thr Glu Trp Asp Leu Val Cys Gln Gln Arg Gly Leu Asn Lys Ile 
     130                135                140
Thr Ser Thr Cys Phe Phe Ile Gly Val Leu Val Gly Ala Val Val Tyr 
 145                150                155                160
Gly Tyr Leu Ser Asp Arg Phe Gly Arg Arg Arg Leu Leu Leu Val Ala 
                 165                170                175
Tyr Val Ser Ser Leu Val Leu Gly Leu Met Ser Ala Ala Ser Ile Asn 
             180                185                190
Tyr Ile Met Phe Val Val Thr Arg Thr Leu Thr Gly Ser Ala Leu Ala 
         195                200                205
Gly Phe Thr Ile Ile Val Leu Pro Leu Glu Leu Glu Trp Leu Asp Val 
     210                215                220
Glu His Arg Thr Val Ala Gly Val Ile Ser Thr Val Phe Trp Ser Gly 
 225                230                235                240
Gly Val Leu Leu Leu Ala Leu Val Gly Tyr Leu Ile Arg Ser Trp Arg 
                 245                250                255
Trp Leu Leu Leu Ala Ala Thr Leu Pro Cys Val Pro Gly Ile Ile Ser 
             260                265                270
Ile Trp Trp Val Pro Glu Ser Ala Arg Trp Leu Leu Thr Gln Gly Arg 
         275                280                285
Val Glu Glu Ala Lys Lys Tyr Leu Leu Ser Cys Ala Lys Leu Asn Gly 
     290                295                300
Arg Pro Val Gly Glu Gly Ser Leu Ser Gln Glu Ala Leu Asn Asn Val 
 305                310                315                320
Val Thr Met Glu Arg Ala Leu Gln Arg Pro Ser Tyr Leu Asp Leu Phe 
                 325                330                335
Arg Thr Ser Gln Leu Arg His Ile Ser Leu Cys Cys Met Met Val Trp 
             340                345                350
Phe Gly Val Asn Phe Ser Tyr Tyr Gly Leu Thr Leu Asp Val Ser Gly 
         355                360                365
Leu Gly Leu Asn Val Tyr Gln Thr Gln Leu Leu Phe Gly Ala Val Glu 
     370                375                380
Leu Pro Ser Lys Ile Met Val Tyr Phe Leu Val Arg Arg Leu Gly Arg 
 385                390                395                400
Arg Leu Thr Glu Ala Gly Met Leu Leu Gly Ala Ala Leu Thr Phe Gly 
                 405                410                415
Thr Ser Leu Leu Val Ser Leu Glu Thr Lys Ser Trp Ile Thr Ala Leu 
             420                425                430
Val Val Val Gly Lys Ala Phe Ser Glu Ala Ala Phe Thr Thr Ala Tyr 
         435                440                445
Leu Phe Thr Ser Glu Leu Tyr Pro Thr Val Leu Arg Gln Thr Gly Leu 
     450                455                460
Gly Leu Thr Ala Leu Met Gly Arg Leu Gly Ala Ser Leu Ala Arg Leu 
 465                470                475                480
Ala Ala Leu Leu Asp Gly Val Trp Leu Leu Leu Pro Lys Val Ala Tyr 
                 485                490                495
Gly Gly Ile Ala Leu Val Ala Ala Cys Thr Ala Leu Leu Leu Pro Glu 
             500                505                510
Thr Lys Lys Ala Gln Leu Pro Glu Thr Ile Gln Asp Val Glu Arg Lys 
         515                520                525
Ser Thr Gln Glu Glu Asp Val 
     530                535



<210> 3127
<211> 1864
<212> DNA
<213> Homo sapiens
<308> AF210455
<400> 3127

atgggcttt  aggagctgc  ggagcaggt  ggcggcttt  ggcccttcc  actgcggaa  60
gtggcactg  tggccctgc  ccgagtgct  ctaccactg  acttcctcc  gcccatctt  120
ctggctgcc  tgcctgccc  ccgatgtgc  ctgccgggt  cccctgcca  cttcagcca  180
caggatgtg  ggctggagg  ccatcttcc  cgggagcct  atggcacgc  cagctcctg  240
ctccgcttt  cctatcccc  ggctctccc  aacaccacg  tgggggaag  aaggcagag  300
cgtggggag  tggaggatg  acctgccac  gtgccctgc  ctcagggct  ggagtacga  360
cactcagaa  tctcctcta  cattgcaac  gagtgggat  tggtgtgtg  gcagaaagg  420
ctgaacaga  ctgcgtcca  tttcttctt  gccggtgtg  tggtggggg  tgtggcctt  480
ggatatctg  ccgacaggt  tgggcggcg  cgtctgctg  tggtagcct  cgtgagtac  540
ctggtgctg  gcctggcat  tgcagcctc  gtcagctat  taatgtttg  catcacccg  600
acccttact  gctcagccc  ggctggttt  accatcatc  tgatgccac  ggagctgga  660
tggctggat  tggagcacc  caccgtggc  ggagtcctg  gcagcacct  ctggacagg  720
ggcgtgatg  tgctggcac  ggttgggta  ctgatacgg  actggcgat  gcttctgct  780
gctgtcacc  tgccttgtg  cccaggcat  ctcagcctc  ggtgggtgc  tgagtctgc  840
cgctggctt  tgacccaag  ccatgtgaa  gaggcccac  ggtacttgc  ccactgtgc  900
aggcccaat  ggcggccag  gtgtgagga  agcttcagc  aggaggctg  gagcaaagt  960
gccgccggg  aacgggtgg  ccgaagacc  tcataccta  acctgttcc  cacaccacg  1020
ctccgacac  tctcactgt  ctgcgtggt  gtgtggttc  gagtgaact  ctcctatta  1080
ggcctgagt  tggatgtgt  ggggctggg  ctgaacgtg  accagacac  gctgttgtt  1140
ggggctgtg  aactgccct  caagctgct  gtctacttg  cggtgcgct  cgcaggacg  1200
cgcctcacg  aagccggga  actgctggg  gcggccctg  cgttcggca  tagactgct  1260
gtgtcctcc  atatgaagt  ctggagcac  gtcctggca  tgatgggga  agctttttc  1320
gaagctgcc  tcaccactg  ctacctgtt  acttcagag  tgtacccta  ggtgctcag  1380
cagacaggg  tggggctga  tgcactggt  ggccggctg  ggggctctt  ggccccact  1440
gcggccttg  tggatggag  gtggctgtc  ctgcccaag  ttacttatg  ggggatcgc  1500
ctgctggct  ccggcaccg  cctcctgct  ccagagacg  ggcaggcac  gctgccaga  1560
accatccag  acgtggaga  aaagaggtg  gtgcacagg  ctgtgtctg  gtacgtgtg  1620
taacatgca  atggatgca  gtgctcaga  acctgacac  ttaggattc  gacaggaaa  1680
tatatctgc  catgtgtac  tggtgcatg  atgtgtgcg  gcacaggtg  gtgtttcag  1740
gtgcatgat  gggggcatg  aaactgcaa  cataaatgt  tacatgagt  tatgaacac  1800
aatacataa  gttgttcag  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1860
aaaa  1864



<210> 3128
<211> 548
<212> PRT
<213> Homo sapiens
<308> AAD37091
<400> 3128

Met Gly Phe Glu Glu Leu Leu Glu Gln Val Gly Gly Phe Gly Pro Phe 
  1               5                  10                  15
Gln Leu Arg Asn Val Ala Leu Leu Ala Leu Pro Arg Val Leu Leu Pro 
             20                  25                  30
Leu His Phe Leu Leu Pro Ile Phe Leu Ala Ala Val Pro Ala His Arg 
         35                  40                  45
Cys Ala Leu Pro Gly Ala Pro Ala Asn Phe Ser His Gln Asp Val Trp 
     50                  55                  60
Leu Glu Ala His Leu Pro Arg Glu Pro Asp Gly Thr Leu Ser Ser Cys 
 65                  70                  75                  80
Leu Arg Phe Ala Tyr Pro Gln Ala Leu Pro Asn Thr Thr Leu Gly Glu 
                 85                  90                  95
Glu Arg Gln Ser Arg Gly Glu Leu Glu Asp Glu Pro Ala Thr Val Pro 
             100                105                110
Cys Ser Gln Gly Trp Glu Tyr Asp His Ser Glu Phe Ser Ser Thr Ile 
         115                120                125
Ala Thr Glu Ser Gln Trp Asp Leu Val Cys Glu Gln Lys Gly Leu Asn 
     130                135                140
Arg Ala Ala Ser Thr Phe Phe Phe Ala Gly Val Leu Val Gly Ala Val 
 145                150                155                160
Ala Phe Gly Tyr Leu Ser Asp Arg Phe Gly Arg Arg Arg Leu Leu Leu 
                 165                170                175
Val Ala Tyr Val Ser Thr Leu Val Leu Gly Leu Ala Ser Ala Ala Ser 
             180                185                190
Val Ser Tyr Val Met Phe Ala Ile Thr Arg Thr Leu Thr Gly Ser Ala 
         195                200                205
Leu Ala Gly Phe Thr Ile Ile Val Met Pro Leu Glu Leu Glu Trp Leu 
     210                215                220
Asp Val Glu His Arg Thr Val Ala Gly Val Leu Ser Ser Thr Phe Trp 
 225                230                235                240
Thr Gly Gly Val Met Leu Leu Ala Leu Val Gly Tyr Leu Ile Arg Asp 
                 245                250                255
Trp Arg Trp Leu Leu Leu Ala Val Thr Leu Pro Cys Ala Pro Gly Ile 
             260                265                270
Leu Ser Leu Trp Trp Val Pro Glu Ser Ala Arg Trp Leu Leu Thr Gln 
         275                280                285
Gly His Val Lys Glu Ala His Arg Tyr Leu Leu His Cys Ala Arg Leu 
     290                295                300
Asn Gly Arg Pro Val Cys Glu Asp Ser Phe Ser Gln Glu Ala Val Ser 
 305                310                315                320
Lys Val Ala Ala Gly Glu Arg Val Val Arg Arg Pro Ser Tyr Leu Asp 
                 325                330                335
Leu Phe Arg Thr Pro Arg Leu Arg His Ile Ser Leu Cys Cys Val Val 
             340                345                350
Val Trp Phe Gly Val Asn Phe Ser Tyr Tyr Gly Leu Ser Leu Asp Val 
         355                360                365
Ser Gly Leu Gly Leu Asn Val Tyr Gln Thr Gln Leu Leu Phe Gly Ala 
     370                375                380
Val Glu Leu Pro Ser Lys Leu Leu Val Tyr Leu Ser Val Arg Tyr Ala 
 385                390                395                400
Gly Arg Arg Leu Thr Gln Ala Gly Thr Leu Leu Gly Thr Ala Leu Ala 
                 405                410                415
Phe Gly Thr Arg Leu Leu Val Ser Ser Asp Met Lys Ser Trp Ser Thr 
             420                425                430
Val Leu Ala Val Met Gly Lys Ala Phe Ser Glu Ala Ala Phe Thr Thr 
         435                440                445
Ala Tyr Leu Phe Thr Ser Glu Leu Tyr Pro Thr Val Leu Arg Gln Thr 
     450                455                460
Gly Met Gly Leu Thr Ala Leu Val Gly Arg Leu Gly Gly Ser Leu Ala 
 465                470                475                480
Pro Leu Ala Ala Leu Leu Asp Gly Val Trp Leu Ser Leu Pro Lys Leu 
                 485                490                495
Thr Tyr Gly Gly Ile Ala Leu Leu Ala Ala Gly Thr Ala Leu Leu Leu 
             500                505                510
Pro Glu Thr Arg Gln Ala Gln Leu Pro Glu Thr Ile Gln Asp Val Glu 
         515                520                525
Arg Lys Ser Ala Pro Thr Ser Leu Gln Glu Glu Glu Met Pro Met Lys 
     530                535                540
Gln Val Gln Asn 
 545



<210> 3129
<211> 1910
<212> DNA
<213> Rattus norvegicus
<308> L27651
<400> 3129

gtccaaggg  ccatgtggt  agcagactg  accgtccta  ataccaaag  gggacacct  60
gtgggtggg  agcatgggc  tcgaagacc  gctggacaa  gtgggcggc  ttgggccct  120
ccaacttcg  aatctggtt  tgatggccc  gccccgaat  ctgctcccc  tgcactttc  180
cctgcccgt  ttcatggcc  ctgtgcctg  ccaccattg  gccctgccc  gtgcccctg  240
caacctcag  caccaggac  tatggctgg  agcccatct  ccccgggag  ctgacggca  300
ctttagctc  tgcctccga  ttgcctatc  ccagactgt  cccaatgtc  ctttgggga  360
agaggtgtc  aactctggg  agcctgagg  tgagcccct  acggtgccc  gctctcagg  420
ctgggagta  gaccgctca  aattctcct  caccattgc  actgagtgg  atcttgtgt  480
tcagcagag  ggactgaac  aaattacgt  cacctgctt  ttcattggt  tgctggtgg  540
agccgtggt  tatggatac  tgtctgaca  gtttggcag  cgccggctt  tgctggtgg  600
ctacgtgag  tccctggtg  tgggtctga  gtctgcagc  tccatcaac  acatcatgt  660
cgtagtcac  cgtacactc  ccggctcag  cctggctgg  ttcaccatc  ttgtgctcc  720
actggagtt  gagtggctg  atgtggagc  ccgcactgt  gccggggtc  tcagcaccg  780
cttctggtc  ggaggcgtg  tgctgctgg  actggtggg  tacctgatc  ggagctggc  840
ctggcttct  ctggctgcc  ccctgccgt  tgtcccagg  atcatcagc  tctggtggg  900
tcctgagtc  gcacggtgg  ttctaaccc  gggtcgtgt  gaggaggca  aaaaatact  960
gctgagctg  gccaagctc  atgggcggc  cgtgggtga  ggcagcctg  gccaggagg  1020
cctgaacaa  gtggtcacc  tggaaaggg  gttgcaaag  ccctcatac  tagacctgt  1080
ccgaacatc  cagctccga  atatctcac  gtgctgcat  atggtgtgg  ttggagtga  1140
cttttccta  tacggcctg  ctctggacg  gtctgggct  gggctgaac  tgtaccaga  1200
acagctgct  tttggggct  tggagctcc  ctccaaaat  atggtctac  tccttgtgc  1260
ccgtctggg  cgccgtctc  cggaggctg  gatgctgct  ggcgctgct  tgacctttg  1320
caccagcct  ctggtatcc  tggagacta  gtcatggat  actgctctg  tggtggtgg  1380
gaaagcttt  tctgaagct  cttttacta  ggcctacct  ttcacgtcc  agttgtacc  1440
tactgtgct  agacagaca  gattgggac  tactgcact  atgggcagg  taggggcct  1500
tctggcccg  ctggcggcc  tgctggatg  agtgtggct  ttgctgccc  aagttgctt  1560
cggggggat  gccctggtg  ctgcctgca  tgcactcct  ctgcctgag  cgaagaagg  1620
acagctgcc  gagaccatc  aggatgtgg  gaggaagag  acccaggag  aagatgtgt  1680
ggtccggga  tgagttgga  tagcgacag  tctccacag  agctgggca  agaaggcag  1740
ctcttgtga  tgggacatc  gactcctcc  cctaaggat  gagctgctc  tgatgccct  1800
tgcctgtgc  ctccagcag  agaacaact  cccgcagca  tgggccgct  ggattctgg  1860
ctcccctct  atggccggg  gcttctata  ataaagacg  ttgctcatgg  1910



<210> 3130
<211> 535
<212> PRT
<213> Rattus norvegicus
<308> AAA57157
<400> 3130

Met Gly Phe Glu Asp Leu Leu Asp Lys Val Gly Gly Phe Gly Pro Phe 
  1               5                  10                  15
Gln Leu Arg Asn Leu Val Leu Met Ala Leu Pro Arg Met Leu Leu Pro 
             20                  25                  30
Met His Phe Leu Leu Pro Val Phe Met Ala Ala Val Pro Ala His His 
         35                  40                  45
Cys Ala Leu Pro Gly Ala Pro Ala Asn Leu Ser His Gln Asp Leu Trp 
     50                  55                  60
Leu Glu Ala His Leu Pro Arg Glu Thr Asp Gly Ser Phe Ser Ser Cys 
 65                  70                  75                  80
Leu Arg Phe Ala Tyr Pro Gln Thr Val Pro Asn Val Thr Leu Gly Thr 
                 85                  90                  95
Glu Val Ser Asn Ser Gly Glu Pro Glu Gly Glu Pro Leu Thr Val Pro 
             100                105                110
Cys Ser Gln Gly Trp Glu Tyr Asp Arg Ser Glu Phe Ser Ser Thr Ile 
         115                120                125
Ala Thr Glu Trp Asp Leu Val Cys Gln Gln Arg Gly Leu Asn Lys Ile 
     130                135                140
Thr Ser Thr Cys Phe Phe Ile Gly Val Leu Val Gly Ala Val Val Tyr 
 145                150                155                160
Gly Tyr Leu Ser Asp Arg Phe Gly Arg Arg Arg Leu Leu Leu Val Ala 
                 165                170                175
Tyr Val Ser Ser Leu Val Leu Gly Leu Met Ser Ala Ala Ser Ile Asn 
             180                185                190
Tyr Ile Met Phe Val Val Thr Arg Thr Leu Thr Gly Ser Ala Leu Ala 
         195                200                205
Gly Phe Thr Ile Ile Val Leu Pro Leu Glu Leu Glu Trp Leu Asp Val 
     210                215                220
Glu His Arg Thr Val Ala Gly Val Ile Ser Thr Val Phe Trp Ser Gly 
 225                230                235                240
Gly Val Leu Leu Leu Ala Leu Val Gly Tyr Leu Ile Arg Ser Trp Arg 
                 245                250                255
Trp Leu Leu Leu Ala Ala Thr Leu Pro Cys Val Pro Gly Ile Ile Ser 
             260                265                270
Ile Trp Trp Val Pro Glu Ser Ala Arg Trp Leu Leu Thr Gln Gly Arg 
         275                280                285
Val Glu Glu Ala Lys Lys Tyr Leu Leu Ser Cys Ala Lys Leu Asn Gly 
     290                295                300
Arg Pro Val Gly Glu Gly Ser Leu Ser Gln Glu Ala Leu Asn Asn Val 
 305                310                315                320
Val Thr Met Glu Arg Ala Leu Gln Arg Pro Ser Tyr Leu Asp Leu Phe 
                 325                330                335
Arg Thr Ser Gln Leu Arg His Ile Ser Leu Cys Cys Met Met Val Trp 
             340                345                350
Phe Gly Val Asn Phe Ser Tyr Tyr Gly Leu Thr Leu Asp Val Ser Gly 
         355                360                365
Leu Gly Leu Asn Val Tyr Gln Thr Gln Leu Leu Phe Gly Ala Val Glu 
     370                375                380
Leu Pro Ser Lys Ile Met Val Tyr Phe Leu Val Arg Arg Leu Gly Arg 
 385                390                395                400
Arg Leu Thr Glu Ala Gly Met Leu Leu Gly Ala Ala Leu Thr Phe Gly 
                 405                410                415
Thr Ser Leu Leu Val Ser Leu Glu Thr Lys Ser Trp Ile Thr Ala Leu 
             420                425                430
Val Val Val Gly Lys Ala Phe Ser Glu Ala Ala Phe Thr Thr Ala Tyr 
         435                440                445
Leu Phe Thr Ser Glu Leu Tyr Pro Thr Val Leu Arg Gln Thr Gly Leu 
     450                455                460
Gly Leu Thr Ala Leu Met Gly Arg Leu Gly Ala Ser Leu Ala Arg Leu 
 465                470                475                480
Ala Ala Leu Leu Asp Gly Val Trp Leu Leu Leu Pro Lys Val Ala Tyr 
                 485                490                495
Gly Gly Ile Ala Leu Val Ala Ala Cys Thr Ala Leu Leu Leu Pro Glu 
             500                505                510
Thr Lys Lys Ala Gln Leu Pro Glu Thr Ile Gln Asp Val Glu Arg Lys 
         515                520                525
Ser Thr Gln Glu Glu Asp Val 
     530                535



<210> 3131
<211> 1864
<212> DNA
<213> Homo sapiens
<308> AF210455
<400> 3131

atgggcttt  aggagctgc  ggagcaggt  ggcggcttt  ggcccttcc  actgcggaa  60
gtggcactg  tggccctgc  ccgagtgct  ctaccactg  acttcctcc  gcccatctt  120
ctggctgcc  tgcctgccc  ccgatgtgc  ctgccgggt  cccctgcca  cttcagcca  180
caggatgtg  ggctggagg  ccatcttcc  cgggagcct  atggcacgc  cagctcctg  240
ctccgcttt  cctatcccc  ggctctccc  aacaccacg  tgggggaag  aaggcagag  300
cgtggggag  tggaggatg  acctgccac  gtgccctgc  ctcagggct  ggagtacga  360
cactcagaa  tctcctcta  cattgcaac  gagtgggat  tggtgtgtg  gcagaaagg  420
ctgaacaga  ctgcgtcca  tttcttctt  gccggtgtg  tggtggggg  tgtggcctt  480
ggatatctg  ccgacaggt  tgggcggcg  cgtctgctg  tggtagcct  cgtgagtac  540
ctggtgctg  gcctggcat  tgcagcctc  gtcagctat  taatgtttg  catcacccg  600
acccttact  gctcagccc  ggctggttt  accatcatc  tgatgccac  ggagctgga  660
tggctggat  tggagcacc  caccgtggc  ggagtcctg  gcagcacct  ctggacagg  720
ggcgtgatg  tgctggcac  ggttgggta  ctgatacgg  actggcgat  gcttctgct  780
gctgtcacc  tgccttgtg  cccaggcat  ctcagcctc  ggtgggtgc  tgagtctgc  840
cgctggctt  tgacccaag  ccatgtgaa  gaggcccac  ggtacttgc  ccactgtgc  900
aggcccaat  ggcggccag  gtgtgagga  agcttcagc  aggaggctg  gagcaaagt  960
gccgccggg  aacgggtgg  ccgaagacc  tcataccta  acctgttcc  cacaccacg  1020
ctccgacac  tctcactgt  ctgcgtggt  gtgtggttc  gagtgaact  ctcctatta  1080
ggcctgagt  tggatgtgt  ggggctggg  ctgaacgtg  accagacac  gctgttgtt  1140
ggggctgtg  aactgccct  caagctgct  gtctacttg  cggtgcgct  cgcaggacg  1200
cgcctcacg  aagccggga  actgctggg  gcggccctg  cgttcggca  tagactgct  1260
gtgtcctcc  atatgaagt  ctggagcac  gtcctggca  tgatgggga  agctttttc  1320
gaagctgcc  tcaccactg  ctacctgtt  acttcagag  tgtacccta  ggtgctcag  1380
cagacaggg  tggggctga  tgcactggt  ggccggctg  ggggctctt  ggccccact  1440
gcggccttg  tggatggag  gtggctgtc  ctgcccaag  ttacttatg  ggggatcgc  1500
ctgctggct  ccggcaccg  cctcctgct  ccagagacg  ggcaggcac  gctgccaga  1560
accatccag  acgtggaga  aaagaggtg  gtgcacagg  ctgtgtctg  gtacgtgtg  1620
taacatgca  atggatgca  gtgctcaga  acctgacac  ttaggattc  gacaggaaa  1680
tatatctgc  catgtgtac  tggtgcatg  atgtgtgcg  gcacaggtg  gtgtttcag  1740
gtgcatgat  gggggcatg  aaactgcaa  cataaatgt  tacatgagt  tatgaacac  1800
aatacataa  gttgttcag  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1860
aaaa  1864



<210> 3132
<211> 548
<212> PRT
<213> Homo sapiens
<308> AAD37091
<400> 3132

Met Gly Phe Glu Glu Leu Leu Glu Gln Val Gly Gly Phe Gly Pro Phe 
  1               5                  10                  15
Gln Leu Arg Asn Val Ala Leu Leu Ala Leu Pro Arg Val Leu Leu Pro 
             20                  25                  30
Leu His Phe Leu Leu Pro Ile Phe Leu Ala Ala Val Pro Ala His Arg 
         35                  40                  45
Cys Ala Leu Pro Gly Ala Pro Ala Asn Phe Ser His Gln Asp Val Trp 
     50                  55                  60
Leu Glu Ala His Leu Pro Arg Glu Pro Asp Gly Thr Leu Ser Ser Cys 
 65                  70                  75                  80
Leu Arg Phe Ala Tyr Pro Gln Ala Leu Pro Asn Thr Thr Leu Gly Glu 
                 85                  90                  95
Glu Arg Gln Ser Arg Gly Glu Leu Glu Asp Glu Pro Ala Thr Val Pro 
             100                105                110
Cys Ser Gln Gly Trp Glu Tyr Asp His Ser Glu Phe Ser Ser Thr Ile 
         115                120                125
Ala Thr Glu Ser Gln Trp Asp Leu Val Cys Glu Gln Lys Gly Leu Asn 
     130                135                140
Arg Ala Ala Ser Thr Phe Phe Phe Ala Gly Val Leu Val Gly Ala Val 
 145                150                155                160
Ala Phe Gly Tyr Leu Ser Asp Arg Phe Gly Arg Arg Arg Leu Leu Leu 
                 165                170                175
Val Ala Tyr Val Ser Thr Leu Val Leu Gly Leu Ala Ser Ala Ala Ser 
             180                185                190
Val Ser Tyr Val Met Phe Ala Ile Thr Arg Thr Leu Thr Gly Ser Ala 
         195                200                205
Leu Ala Gly Phe Thr Ile Ile Val Met Pro Leu Glu Leu Glu Trp Leu 
     210                215                220
Asp Val Glu His Arg Thr Val Ala Gly Val Leu Ser Ser Thr Phe Trp 
 225                230                235                240
Thr Gly Gly Val Met Leu Leu Ala Leu Val Gly Tyr Leu Ile Arg Asp 
                 245                250                255
Trp Arg Trp Leu Leu Leu Ala Val Thr Leu Pro Cys Ala Pro Gly Ile 
             260                265                270
Leu Ser Leu Trp Trp Val Pro Glu Ser Ala Arg Trp Leu Leu Thr Gln 
         275                280                285
Gly His Val Lys Glu Ala His Arg Tyr Leu Leu His Cys Ala Arg Leu 
     290                295                300
Asn Gly Arg Pro Val Cys Glu Asp Ser Phe Ser Gln Glu Ala Val Ser 
 305                310                315                320
Lys Val Ala Ala Gly Glu Arg Val Val Arg Arg Pro Ser Tyr Leu Asp 
                 325                330                335
Leu Phe Arg Thr Pro Arg Leu Arg His Ile Ser Leu Cys Cys Val Val 
             340                345                350
Val Trp Phe Gly Val Asn Phe Ser Tyr Tyr Gly Leu Ser Leu Asp Val 
         355                360                365
Ser Gly Leu Gly Leu Asn Val Tyr Gln Thr Gln Leu Leu Phe Gly Ala 
     370                375                380
Val Glu Leu Pro Ser Lys Leu Leu Val Tyr Leu Ser Val Arg Tyr Ala 
 385                390                395                400
Gly Arg Arg Leu Thr Gln Ala Gly Thr Leu Leu Gly Thr Ala Leu Ala 
                 405                410                415
Phe Gly Thr Arg Leu Leu Val Ser Ser Asp Met Lys Ser Trp Ser Thr 
             420                425                430
Val Leu Ala Val Met Gly Lys Ala Phe Ser Glu Ala Ala Phe Thr Thr 
         435                440                445
Ala Tyr Leu Phe Thr Ser Glu Leu Tyr Pro Thr Val Leu Arg Gln Thr 
     450                455                460
Gly Met Gly Leu Thr Ala Leu Val Gly Arg Leu Gly Gly Ser Leu Ala 
 465                470                475                480
Pro Leu Ala Ala Leu Leu Asp Gly Val Trp Leu Ser Leu Pro Lys Leu 
                 485                490                495
Thr Tyr Gly Gly Ile Ala Leu Leu Ala Ala Gly Thr Ala Leu Leu Leu 
             500                505                510
Pro Glu Thr Arg Gln Ala Gln Leu Pro Glu Thr Ile Gln Asp Val Glu 
         515                520                525
Arg Lys Ser Ala Pro Thr Ser Leu Gln Glu Glu Glu Met Pro Met Lys 
     530                535                540
Gln Val Gln Asn 
 545



<210> 3133
<211> 1814
<212> DNA
<213> Rattus norvegicus
<308> L27663
<400> 3133

ccaaggcag  aaagtaact  tcaaatgcg  ggctccttt  accagagcg  ccagtccgg  60
tccgagagt  atggcgacc  cagcgtcta  ccactacag  ctgctcacc  ccagcgcct  120
catcgtgca  gccgagccg  ctggcggca  gcagcaggg  gcggggggc  accgcgagg  180
gcagagcct  caggtgcag  gcgactacg  tgcgctgca  agcaacggg  acccgctca  240
ccacgctca  tggatcacc  cgctgtccc  cggcggcag  ggcgggggc  gcggcggtg  300
tggaggagg  gggggaggc  gcgggggag  cggcgacgg  tccccgtgg  ccaccagcc  360
cctaggcca  ccggacatc  agccctcgg  ggtggtaca  cagggtggc  gaggcgacg  420
gctgcacgg  ccaggagcg  tgcagcagc  gcaccaaca  caacagcag  agcagcaac  480
gcaacagca  caacaacag  aacagcagc  gcagcaaca  cagcgaccg  cacatctgg  540
gcaccacgc  gccaacaac  atcccgggc  cggggcatg  cggagtgcg  cggctgcag  600
tcaccttcc  ccctccatg  gagcttcca  cggtggttt  ctctattcg  agcccagct  660
cacggtgaa  ggcatgctg  gcgcaggag  gcagccggc  gggctgcac  accacggcc  720
gagggacgc  cacgatgag  cccatcatg  agaccacca  ccgcatccg  actctcacc  780
gcaccagca  ccgcccccg  cacctcccc  acaaggccc  ccgggccac  caggcgcgc  840
ccacgaccc  cactcggac  aggacacgc  gacctcaga  gacctggag  agttcgcca  900
gcaattcaa  cagaggcgg  tcaaactag  atttactca  gcagacgtg  ggctggcgc  960
tggcaccct  tacggcaac  tcttctcgc  gaccaccat  tgcaggttt  aggccctgc  1020
gctgagctt  aagaacatg  gcaagctga  gcctttgtt  aacaagtgg  tggaagagg  1080
agactcatc  tcgggcagc  ccaccagca  agacaagat  gcttcgcaa  ggcgcaaac  1140
gaaaaagcg  acctccatc  aggtgagcg  caagggggc  ctggagagc  atttcctca  1200
atgccctaa  ccctcggcc  aggagatca  ctccctcgc  gacagctta  agctggaga  1260
ggaggtggt  agagtttgg  tttgtaaca  gagacagaa  gagaaaagg  tgacccctc  1320
cggagggac  ctgccgggc  ccgaggatg  gtatggggg  agtagggac  cgccaccac  1380
ccacggggt  cagacgccc  tccagtgaa  tcaagcagg  gaggggcag  gcttggggc  1440
cccctcccc  ttggtccac  gtctcaact  ggacctctg  tccccctgt  acttctgat  1500
gtttttttt  tttaattat  attttcccg  tcccttaaa  agagaaaaa  atagagaaa  1560
taaggagaa  ggaaagtaa  agtaaaaca  tggactaac  tataacagg  agcaggtgt  1620
ttcatgggt  ttgaccttt  caagcgagt  cccaggcaa  gaagtagaa  gtctcctag  1680
aagagtgaa  tgtgtgtgt  tgtgtgtgt  tgtgtgtgt  tgtctgtgt  tgaaagaga  1740
agagagaga  agagagaga  agagagaga  agagagaga  agggaggag  cctggtaaa  1800
ctaaataaa  tacc  1814



<210> 3134
<211> 445
<212> PRT
<213> Rattus norvegicus
<308> P56222
<400> 3134

Met Ala Thr Ala Ala Ser Asn His Tyr Ser Leu Leu Thr Ser Ser Ala 
  1               5                  10                  15
Ser Ile Val His Ala Glu Pro Pro Gly Gly Met Gln Gln Gly Ala Gly 
             20                  25                  30
Gly Tyr Arg Glu Ala Gln Ser Leu Gln Val Gln Gly Asp Tyr Gly Ala 
         35                  40                  45
Leu Gln Ser Asn Gly His Pro Leu Ser His Ala His Trp Ile Thr Ala 
     50                  55                  60
Leu Ser His Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
 65                  70                  75                  80
Gly Gly Gly Gly Gly Gly Gly Gly Asp Gly Ser Pro Trp Ser Thr Ser 
                 85                  90                  95
Pro Leu Gly Gln Pro Asp Ile Lys Pro Ser Val Val Val Gln Gln Gly 
             100                105                110
Gly Arg Gly Asp Glu Leu His Gly Pro Gly Ala Leu Gln Gln Gln His 
         115                120                125
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
     130                135                140
Gln Gln Gln Gln Gln Gln Gln Arg Pro Pro His Leu Val His His Ala 
 145                150                155                160
Ala Asn Asn His Pro Gly Pro Gly Ala Trp Arg Ser Ala Ala Ala Ala 
                 165                170                175
Ala His Leu Pro Pro Ser Met Gly Ala Ser Asn Gly Gly Leu Leu Tyr 
             180                185                190
Ser Gln Pro Ser Phe Thr Val Asn Gly Met Leu Gly Ala Gly Gly Gln 
         195                200                205
Pro Ala Gly Leu His His His Gly Leu Arg Asp Ala His Asp Glu Pro 
     210                215                220
His His Ala Asp His His Pro His Pro His Ser His Pro His Gln Gln 
 225                230                235                240
Pro Pro Pro Pro Pro Pro Pro Gln Gly Pro Pro Gly His Pro Gly Ala 
                 245                250                255
His His Asp Pro His Ser Asp Glu Asp Thr Pro Thr Ser Asp Asp Leu 
             260                265                270
Glu Gln Phe Ala Lys Gln Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe 
         275                280                285
Thr Gln Ala Asp Val Gly Leu Ala Leu Gly Thr Leu Tyr Gly Asn Val 
     290                295                300
Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu Ser Phe 
 305                310                315                320
Lys Asn Met Cys Lys Leu Lys Pro Leu Leu Asn Lys Trp Leu Glu Glu 
                 325                330                335
Ala Asp Ser Ser Ser Gly Ser Pro Thr Ser Ile Asp Lys Ile Ala Ser 
             340                345                350
Gln Gly Arg Lys Arg Lys Lys Arg Thr Ser Ile Glu Val Ser Val Lys 
         355                360                365
Gly Ala Leu Glu Ser His Phe Leu Lys Cys Pro Lys Pro Ser Ala Gln 
     370                375                380
Glu Ile Thr Ser Leu Ala Asp Ser Leu Gln Leu Glu Lys Glu Val Val 
 385                390                395                400
Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Met Thr Pro 
                 405                410                415
Pro Gly Gly Thr Leu Pro Gly Ala Glu Asp Val Tyr Gly Gly Ser Arg 
             420                425                430
Asp Thr Pro Pro His His Gly Val Gln Thr Pro Val Gln 
         435                440                445



<210> 3135
<211> 1955
<212> DNA
<213> Homo sapiens
<308> Z11933
<400> 3135

gaattccgg  aacagaagg  gtcggagcg  gcgtcggag  tgcccgctg  gggagagag  60
ggagacaga  agagcgagc  aggagaggg  gcccgaggc  aaaaagtaa  tgtcaaatg  120
gcggctcct  taaccggag  gctcagtcc  gctccgaga  tcatggcga  cgcagcgtc  180
aaccactac  gcctgctca  ctccagcgc  tccatcgtg  acgccgagc  gcccggcgc  240
atgcagcag  gcgcggggg  ctaccgcga  gcgcagagc  tggtgcagg  cgactacgg  300
gctctgcag  gcaacggac  cccgctcag  cacgctcac  agtggatca  cgcgctgtc  360
cacggcggc  gcggcgggg  cggtggcgg  ggcgggggg  gcgggggcg  cggcggggg  420
ggcggcgac  gctccccgt  gtccaccag  cccctgggc  agccggaca  caagccctc  480
gtggtggtg  agcagggcg  ccgcggaga  gagctgcac  ggccaggcg  cctgcagca  540
cagcatcag  agcagcaac  gcaacagca  cagcaacag  agcaacagc  gcagcagca  600
cagcaacag  ggccgccgc  tctggtgca  cacgccgct  accaccacc  gggacccgg  660
gcatggcgg  cggcggcgg  tgcagcgca  ctcccaccc  ccatgggag  gtccaacgg  720
ggcttgctc  actcgcagc  cagcttcac  gtgaacggc  tgctgggcg  cggcgggca  780
ccggccggg  tgcaccacc  cggcctgcg  gacgcgcac  acgagccac  ccatgccga  840
caccacccg  acccgcact  gcacccaca  cagcagccg  cgcccccgc  gcccccgca  900
ggtccgcct  gccacccag  cgcgcacca  gacccgcac  cggacgagg  cacgccgac  960
tcggacgac  tggagcagt  cgccaagca  ttcaagcag  ggcggatca  actgggatt  1020
acccaagcg  acgtggggc  ggctctggg  accctgtat  gcaacgtgt  ctcgcagac  1080
accatctgc  ggtttgagg  cctgcagct  agcttcaag  acatgtgca  gctgaagcc  1140
ttgttgaac  agtggttgg  ggaggcgga  tcgtcctcg  gcagcccca  gagcataga  1200
aagatcgca  cgcaagggc  caagcggaa  aagcggacc  ccatcgagg  gagcgtcaa  1260
ggggctctg  agagccatt  cctcaaatg  cccaagccc  cggcccagg  gatcacctc  1320
ctcgcggac  gcttacagc  ggagaagga  gtggtgaga  tttggtttt  taacaggag  1380
cagaaagag  aaaggatga  ccctcccgg  gggactctg  cgggcgccg  ggatgtgta  1440
ggggggagt  gggacactc  accacacca  ggggtgcag  cgcccgtcc  gtgaactcg  1500
gctggggga  gggcagagc  cggggctcc  cctcccctt  ggtccttgg  cctttcccg  1560
ccctcttgt  ccctctcta  cttctgatt  ttcttttat  tttaattat  atttccccg  1620
cccttaaaa  gacaaaaaa  ataaggcaa  aggaaagca  ctaagacac  ggactatcc  1680
ttaaaggta  caggtgtaa  gatgtgttt  gacctttgc  ggcgagtaa  caggcaatg  1740
agtggagtg  ctcctggag  gagtgagga  agtgtgtga  agctagaaa  agagagaga  1800
agagagatg  caagcactg  gataaatac  tggcaaaac  aaataaatt  ccaaaaagg  1860
aaaaaaatc  accaaacca  gataaacac  aaatgcagc  tcctgatgc  tagagttgg  1920
acatgctgc  gtgtttatt  attgtggag  aattc  1955



<210> 3136
<211> 443
<212> PRT
<213> Homo sapiens
<308> P20265
<400> 3136

Met Ala Thr Ala Ala Ser Asn His Tyr Ser Leu Leu Thr Ser Ser Ala 
  1               5                  10                  15
Ser Ile Val His Ala Glu Pro Pro Gly Ala Met Gln Gln Gly Ala Gly 
             20                  25                  30
Gly Tyr Arg Glu Ala Gln Ser Leu Val Gln Gly Asp Tyr Gly Ala Leu 
         35                  40                  45
Gln Ser Asn Gly His Pro Leu Ser His Ala His Gln Trp Ile Thr Ala 
     50                  55                  60
Leu Ser His Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
 65                  70                  75                  80
Gly Gly Gly Gly Gly Gly Gly Gly Asp Gly Ser Pro Trp Ser Thr Ser 
                 85                  90                  95
Pro Leu Gly Gln Pro Asp Ile Lys Pro Ser Val Val Val Gln Gln Gly 
             100                105                110
Gly Arg Gly Asp Glu Leu His Gly Pro Gly Ala Leu Gln Gln Gln His 
         115                120                125
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
     130                135                140
Gln Gln Gln Gln Gln Arg Pro Pro His Leu Val His His Ala Ala Asn 
 145                150                155                160
His His Pro Gly Pro Gly Ala Trp Arg Thr Ala Ala Ala Ala Ala His 
                 165                170                175
Leu Pro Pro Ser Met Gly Ala Ser Asn Gly Gly Leu Leu Tyr Ser Gln 
             180                185                190
Pro Ser Phe Thr Val Asn Gly Met Leu Gly Ala Gly Gly Gln Pro Ala 
         195                200                205
Gly Leu His His His Gly Leu Arg Asp Ala His Asp Glu Pro His His 
     210                215                220
Ala Asp His His Pro His Pro His Ser His Pro His Gln Gln Pro Pro 
 225                230                235                240
Pro Pro Pro Pro Pro Gln Gly Pro Pro Gly His Pro Gly Ala His His 
                 245                250                255
Asp Pro His Ser Asp Glu Asp Thr Pro Thr Ser Asp Asp Leu Glu Gln 
             260                265                270
Phe Ala Lys Gln Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln 
         275                280                285
Ala Asp Val Gly Leu Ala Leu Gly Thr Leu Tyr Gly Asn Val Phe Ser 
     290                295                300
Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu Ser Phe Lys Asn 
 305                310                315                320
Met Cys Lys Leu Lys Pro Leu Leu Asn Lys Trp Leu Glu Glu Ala Asp 
                 325                330                335
Ser Ser Ser Gly Ser Pro Thr Ser Ile Asp Lys Ile Ala Ala Gln Gly 
             340                345                350
Arg Lys Arg Lys Lys Arg Thr Ser Ile Glu Val Ser Val Lys Gly Ala 
         355                360                365
Leu Glu Ser His Phe Leu Lys Cys Pro Lys Pro Ser Ala Gln Glu Ile 
     370                375                380
Thr Ser Leu Ala Asp Ser Leu Gln Leu Glu Lys Glu Val Val Arg Val 
 385                390                395                400
Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Met Thr Pro Pro Gly 
                 405                410                415
Gly Thr Leu Pro Gly Ala Glu Asp Val Tyr Gly Gly Ser Arg Asp Thr 
             420                425                430
Pro Pro His His Gly Val Gln Thr Pro Val Gln 
         435                440



<210> 3137
<211> 1814
<212> DNA
<213> Rattus norvegicus
<308> L27663
<400> 3137

ccaaggcag  aaagtaact  tcaaatgcg  ggctccttt  accagagcg  ccagtccgg  60
tccgagagt  atggcgacc  cagcgtcta  ccactacag  ctgctcacc  ccagcgcct  120
catcgtgca  gccgagccg  ctggcggca  gcagcaggg  gcggggggc  accgcgagg  180
gcagagcct  caggtgcag  gcgactacg  tgcgctgca  agcaacggg  acccgctca  240
ccacgctca  tggatcacc  cgctgtccc  cggcggcag  ggcgggggc  gcggcggtg  300
tggaggagg  gggggaggc  gcgggggag  cggcgacgg  tccccgtgg  ccaccagcc  360
cctaggcca  ccggacatc  agccctcgg  ggtggtaca  cagggtggc  gaggcgacg  420
gctgcacgg  ccaggagcg  tgcagcagc  gcaccaaca  caacagcag  agcagcaac  480
gcaacagca  caacaacag  aacagcagc  gcagcaaca  cagcgaccg  cacatctgg  540
gcaccacgc  gccaacaac  atcccgggc  cggggcatg  cggagtgcg  cggctgcag  600
tcaccttcc  ccctccatg  gagcttcca  cggtggttt  ctctattcg  agcccagct  660
cacggtgaa  ggcatgctg  gcgcaggag  gcagccggc  gggctgcac  accacggcc  720
gagggacgc  cacgatgag  cccatcatg  agaccacca  ccgcatccg  actctcacc  780
gcaccagca  ccgcccccg  cacctcccc  acaaggccc  ccgggccac  caggcgcgc  840
ccacgaccc  cactcggac  aggacacgc  gacctcaga  gacctggag  agttcgcca  900
gcaattcaa  cagaggcgg  tcaaactag  atttactca  gcagacgtg  ggctggcgc  960
tggcaccct  tacggcaac  tcttctcgc  gaccaccat  tgcaggttt  aggccctgc  1020
gctgagctt  aagaacatg  gcaagctga  gcctttgtt  aacaagtgg  tggaagagg  1080
agactcatc  tcgggcagc  ccaccagca  agacaagat  gcttcgcaa  ggcgcaaac  1140
gaaaaagcg  acctccatc  aggtgagcg  caagggggc  ctggagagc  atttcctca  1200
atgccctaa  ccctcggcc  aggagatca  ctccctcgc  gacagctta  agctggaga  1260
ggaggtggt  agagtttgg  tttgtaaca  gagacagaa  gagaaaagg  tgacccctc  1320
cggagggac  ctgccgggc  ccgaggatg  gtatggggg  agtagggac  cgccaccac  1380
ccacggggt  cagacgccc  tccagtgaa  tcaagcagg  gaggggcag  gcttggggc  1440
cccctcccc  ttggtccac  gtctcaact  ggacctctg  tccccctgt  acttctgat  1500
gtttttttt  tttaattat  attttcccg  tcccttaaa  agagaaaaa  atagagaaa  1560
taaggagaa  ggaaagtaa  agtaaaaca  tggactaac  tataacagg  agcaggtgt  1620
ttcatgggt  ttgaccttt  caagcgagt  cccaggcaa  gaagtagaa  gtctcctag  1680
aagagtgaa  tgtgtgtgt  tgtgtgtgt  tgtgtgtgt  tgtctgtgt  tgaaagaga  1740
agagagaga  agagagaga  agagagaga  agagagaga  agggaggag  cctggtaaa  1800
ctaaataaa  tacc  1814



<210> 3138
<211> 445
<212> PRT
<213> Rattus norvegicus
<308> P56222
<400> 3138

Met Ala Thr Ala Ala Ser Asn His Tyr Ser Leu Leu Thr Ser Ser Ala 
  1               5                  10                  15
Ser Ile Val His Ala Glu Pro Pro Gly Gly Met Gln Gln Gly Ala Gly 
             20                  25                  30
Gly Tyr Arg Glu Ala Gln Ser Leu Gln Val Gln Gly Asp Tyr Gly Ala 
         35                  40                  45
Leu Gln Ser Asn Gly His Pro Leu Ser His Ala His Trp Ile Thr Ala 
     50                  55                  60
Leu Ser His Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
 65                  70                  75                  80
Gly Gly Gly Gly Gly Gly Gly Gly Asp Gly Ser Pro Trp Ser Thr Ser 
                 85                  90                  95
Pro Leu Gly Gln Pro Asp Ile Lys Pro Ser Val Val Val Gln Gln Gly 
             100                105                110
Gly Arg Gly Asp Glu Leu His Gly Pro Gly Ala Leu Gln Gln Gln His 
         115                120                125
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
     130                135                140
Gln Gln Gln Gln Gln Gln Gln Arg Pro Pro His Leu Val His His Ala 
 145                150                155                160
Ala Asn Asn His Pro Gly Pro Gly Ala Trp Arg Ser Ala Ala Ala Ala 
                 165                170                175
Ala His Leu Pro Pro Ser Met Gly Ala Ser Asn Gly Gly Leu Leu Tyr 
             180                185                190
Ser Gln Pro Ser Phe Thr Val Asn Gly Met Leu Gly Ala Gly Gly Gln 
         195                200                205
Pro Ala Gly Leu His His His Gly Leu Arg Asp Ala His Asp Glu Pro 
     210                215                220
His His Ala Asp His His Pro His Pro His Ser His Pro His Gln Gln 
 225                230                235                240
Pro Pro Pro Pro Pro Pro Pro Gln Gly Pro Pro Gly His Pro Gly Ala 
                 245                250                255
His His Asp Pro His Ser Asp Glu Asp Thr Pro Thr Ser Asp Asp Leu 
             260                265                270
Glu Gln Phe Ala Lys Gln Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe 
         275                280                285
Thr Gln Ala Asp Val Gly Leu Ala Leu Gly Thr Leu Tyr Gly Asn Val 
     290                295                300
Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu Ser Phe 
 305                310                315                320
Lys Asn Met Cys Lys Leu Lys Pro Leu Leu Asn Lys Trp Leu Glu Glu 
                 325                330                335
Ala Asp Ser Ser Ser Gly Ser Pro Thr Ser Ile Asp Lys Ile Ala Ser 
             340                345                350
Gln Gly Arg Lys Arg Lys Lys Arg Thr Ser Ile Glu Val Ser Val Lys 
         355                360                365
Gly Ala Leu Glu Ser His Phe Leu Lys Cys Pro Lys Pro Ser Ala Gln 
     370                375                380
Glu Ile Thr Ser Leu Ala Asp Ser Leu Gln Leu Glu Lys Glu Val Val 
 385                390                395                400
Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Met Thr Pro 
                 405                410                415
Pro Gly Gly Thr Leu Pro Gly Ala Glu Asp Val Tyr Gly Gly Ser Arg 
             420                425                430
Asp Thr Pro Pro His His Gly Val Gln Thr Pro Val Gln 
         435                440                445



<210> 3139
<211> 1955
<212> DNA
<213> Homo sapiens
<308> Z11933
<400> 3139

gaattccgg  aacagaagg  gtcggagcg  gcgtcggag  tgcccgctg  gggagagag  60
ggagacaga  agagcgagc  aggagaggg  gcccgaggc  aaaaagtaa  tgtcaaatg  120
gcggctcct  taaccggag  gctcagtcc  gctccgaga  tcatggcga  cgcagcgtc  180
aaccactac  gcctgctca  ctccagcgc  tccatcgtg  acgccgagc  gcccggcgc  240
atgcagcag  gcgcggggg  ctaccgcga  gcgcagagc  tggtgcagg  cgactacgg  300
gctctgcag  gcaacggac  cccgctcag  cacgctcac  agtggatca  cgcgctgtc  360
cacggcggc  gcggcgggg  cggtggcgg  ggcgggggg  gcgggggcg  cggcggggg  420
ggcggcgac  gctccccgt  gtccaccag  cccctgggc  agccggaca  caagccctc  480
gtggtggtg  agcagggcg  ccgcggaga  gagctgcac  ggccaggcg  cctgcagca  540
cagcatcag  agcagcaac  gcaacagca  cagcaacag  agcaacagc  gcagcagca  600
cagcaacag  ggccgccgc  tctggtgca  cacgccgct  accaccacc  gggacccgg  660
gcatggcgg  cggcggcgg  tgcagcgca  ctcccaccc  ccatgggag  gtccaacgg  720
ggcttgctc  actcgcagc  cagcttcac  gtgaacggc  tgctgggcg  cggcgggca  780
ccggccggg  tgcaccacc  cggcctgcg  gacgcgcac  acgagccac  ccatgccga  840
caccacccg  acccgcact  gcacccaca  cagcagccg  cgcccccgc  gcccccgca  900
ggtccgcct  gccacccag  cgcgcacca  gacccgcac  cggacgagg  cacgccgac  960
tcggacgac  tggagcagt  cgccaagca  ttcaagcag  ggcggatca  actgggatt  1020
acccaagcg  acgtggggc  ggctctggg  accctgtat  gcaacgtgt  ctcgcagac  1080
accatctgc  ggtttgagg  cctgcagct  agcttcaag  acatgtgca  gctgaagcc  1140
ttgttgaac  agtggttgg  ggaggcgga  tcgtcctcg  gcagcccca  gagcataga  1200
aagatcgca  cgcaagggc  caagcggaa  aagcggacc  ccatcgagg  gagcgtcaa  1260
ggggctctg  agagccatt  cctcaaatg  cccaagccc  cggcccagg  gatcacctc  1320
ctcgcggac  gcttacagc  ggagaagga  gtggtgaga  tttggtttt  taacaggag  1380
cagaaagag  aaaggatga  ccctcccgg  gggactctg  cgggcgccg  ggatgtgta  1440
ggggggagt  gggacactc  accacacca  ggggtgcag  cgcccgtcc  gtgaactcg  1500
gctggggga  gggcagagc  cggggctcc  cctcccctt  ggtccttgg  cctttcccg  1560
ccctcttgt  ccctctcta  cttctgatt  ttcttttat  tttaattat  atttccccg  1620
cccttaaaa  gacaaaaaa  ataaggcaa  aggaaagca  ctaagacac  ggactatcc  1680
ttaaaggta  caggtgtaa  gatgtgttt  gacctttgc  ggcgagtaa  caggcaatg  1740
agtggagtg  ctcctggag  gagtgagga  agtgtgtga  agctagaaa  agagagaga  1800
agagagatg  caagcactg  gataaatac  tggcaaaac  aaataaatt  ccaaaaagg  1860
aaaaaaatc  accaaacca  gataaacac  aaatgcagc  tcctgatgc  tagagttgg  1920
acatgctgc  gtgtttatt  attgtggag  aattc  1955



<210> 3140
<211> 443
<212> PRT
<213> Homo sapiens
<308> P20265
<400> 3140

Met Ala Thr Ala Ala Ser Asn His Tyr Ser Leu Leu Thr Ser Ser Ala 
  1               5                  10                  15
Ser Ile Val His Ala Glu Pro Pro Gly Ala Met Gln Gln Gly Ala Gly 
             20                  25                  30
Gly Tyr Arg Glu Ala Gln Ser Leu Val Gln Gly Asp Tyr Gly Ala Leu 
         35                  40                  45
Gln Ser Asn Gly His Pro Leu Ser His Ala His Gln Trp Ile Thr Ala 
     50                  55                  60
Leu Ser His Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
 65                  70                  75                  80
Gly Gly Gly Gly Gly Gly Gly Gly Asp Gly Ser Pro Trp Ser Thr Ser 
                 85                  90                  95
Pro Leu Gly Gln Pro Asp Ile Lys Pro Ser Val Val Val Gln Gln Gly 
             100                105                110
Gly Arg Gly Asp Glu Leu His Gly Pro Gly Ala Leu Gln Gln Gln His 
         115                120                125
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
     130                135                140
Gln Gln Gln Gln Gln Arg Pro Pro His Leu Val His His Ala Ala Asn 
 145                150                155                160
His His Pro Gly Pro Gly Ala Trp Arg Thr Ala Ala Ala Ala Ala His 
                 165                170                175
Leu Pro Pro Ser Met Gly Ala Ser Asn Gly Gly Leu Leu Tyr Ser Gln 
             180                185                190
Pro Ser Phe Thr Val Asn Gly Met Leu Gly Ala Gly Gly Gln Pro Ala 
         195                200                205
Gly Leu His His His Gly Leu Arg Asp Ala His Asp Glu Pro His His 
     210                215                220
Ala Asp His His Pro His Pro His Ser His Pro His Gln Gln Pro Pro 
 225                230                235                240
Pro Pro Pro Pro Pro Gln Gly Pro Pro Gly His Pro Gly Ala His His 
                 245                250                255
Asp Pro His Ser Asp Glu Asp Thr Pro Thr Ser Asp Asp Leu Glu Gln 
             260                265                270
Phe Ala Lys Gln Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln 
         275                280                285
Ala Asp Val Gly Leu Ala Leu Gly Thr Leu Tyr Gly Asn Val Phe Ser 
     290                295                300
Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu Ser Phe Lys Asn 
 305                310                315                320
Met Cys Lys Leu Lys Pro Leu Leu Asn Lys Trp Leu Glu Glu Ala Asp 
                 325                330                335
Ser Ser Ser Gly Ser Pro Thr Ser Ile Asp Lys Ile Ala Ala Gln Gly 
             340                345                350
Arg Lys Arg Lys Lys Arg Thr Ser Ile Glu Val Ser Val Lys Gly Ala 
         355                360                365
Leu Glu Ser His Phe Leu Lys Cys Pro Lys Pro Ser Ala Gln Glu Ile 
     370                375                380
Thr Ser Leu Ala Asp Ser Leu Gln Leu Glu Lys Glu Val Val Arg Val 
 385                390                395                400
Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Met Thr Pro Pro Gly 
                 405                410                415
Gly Thr Leu Pro Gly Ala Glu Asp Val Tyr Gly Gly Ser Arg Asp Thr 
             420                425                430
Pro Pro His His Gly Val Gln Thr Pro Val Gln 
         435                440



<210> 3141
<211> 2638
<212> DNA
<213> Rattus norvegicus
<308> L27843
<400> 3141

cacaatctt  aatgagtag  catattcct  agttctgtg  tgttctcgg  cacacattt  60
tggagtttc  gaagggcag  ggagactac  gccaggcac  gcacgacct  tatgcagac  120
agtgaactg  agaaattca  tactactcc  ccaagaagc  cccataaga  tggatagcc  180
ggacacagt  gtgttgaat  gaaatctgc  gagcatttt  caagagctc  gacctggat  240
gggtaaacc  cagtgcact  cctctgtat  gcctcagta  tcctggatt  aagagtcac  300
gcttcttgt  aggaggttc  tttcattgc  cgtttctcc  gactcatac  caaagcact  360
agaatttca  gtggagtat  ttgaatatt  aagtagact  caggttgtt  tttggtttt  420
ttttggttt  ttgttttgt  ttgttttgt  ttgttttgg  tttcagttt  tgtttggaa  480
catttctgt  ttcaatttt  taattcttt  ataacccta  tgggtgttt  tttaaacta  540
attaacatg  ctcgaatga  ccgccctgc  cctgtggaa  tcacataca  gaacatgag  600
tttcttatt  cacacaatc  aaccaatgc  accttaaac  aatttatag  ggaacttaa  660
aagtatgga  ttaccacaa  agtaagagt  tgcgaagca  cttacgaca  tactcttgt  720
gagaaagaa  gcattcatg  tcttgactg  ccttttgat  atggtgcac  accatccaa  780
cagattgtt  atgactggt  aagtcttgt  aagattaag  ttcgtgaag  acctggttg  840
tgtattgct  tccattgtg  cgcaggcct  ggcagagct  cggtgcttg  tgccctagc  900
ttaattgaa  gtggaatga  atatgaaga  gcagtacaa  tcataagac  aaagcggcg  960
ggagctttt  acagcaagc  acttctgta  ctggagaag  accgtccta  aatgcggct  1020
cgcttcaag  attccaacg  tcatagaaa  aactgttgt  ttcaataaa  ctggggtgc  1080
tgatgccat  gccttggaa  aggaacttc  gatgggacc  gatttgtta  ttacccaat  1140
tgtccactt  cctgtggaa  ctccagggg  atattgaaa  agttttacc  ggccacaag  1200
ttgacagaa  tgcaacctc  ataattggg  tatgatcaa  acgtttgga  acttagcaa  1260
agatttttg  tggtcagca  ttaaaatgt  cttattatt  gtaccaatt  acctttcct  1320
aaataaggt  ttgagtaat  tcattaaat  tactcctgt  ccagaatat  attagtcta  1380
aaggaattt  gaaggatta  gtgccaaaa  acccagcac  atacttgta  atttttagc  1440
tcatacaga  ccaaaattc  aagaactaa  aactctcca  accttccat  gtgtattcc  1500
tcagtcatt  caaacaccg  agggcttct  ttgttatct  cctgctcac  ctatgttta  1560
atctcccac  cttacacca  aacacatca  gtttgctta  ctatctttt  agtcttgca  1620
tgattattt  atgtctctg  cttattttg  gctgttttg  gaaacctcc  tttgaaaat  1680
aactttgtt  cagaagcac  tatcttcaa  aatgtctcc  gacaaaaag  cttatagtt  1740
atttaatgt  tgcactcgg  tgcaacctg  cagggaggg  ctgaacaag  aaggagagg  1800
ggctattaa  tatttttag  aatatgttg  ctttgtctt  tgcagaaca  gtagagtat  1860
ctctttaat  tagtaaata  ttttaagac  tagagatac  ttgttgtag  taaccactt  1920
atcaaaatt  ctgaaattc  tgtgttttc  atacctatc  gaggttttc  aacttgttt  1980
aattatggt  ttccccttc  cttcccaat  tcttgcaaa  aagtaaaag  gggatctgc  2040
agtgaactg  gcagaaata  tttatacgc  ttttgagct  tgtaactta  taattggat  2100
cttgatcat  tgttttatt  tgtaatcga  aaaatggtg  tgtgtatta  tgttagttc  2160
accatatat  tatactgtc  gggaatgtg  ggttatagt  ctgtgggag  aatagtttg  2220
cagtgttca  cagcttgta  aaacttagt  cgagagctt  aacatctaa  taaatgatg  2280
aacgcattc  tcactgagg  cactttgct  aaaattaac  taatttgta  aaaacagtg  2340
attcaatta  tatcatttc  gtttatgga  aaatttgtt  gggttacca  gtgcgttta  2400
aaattgctc  ttaaaggtc  agataattg  gaatcaatt  aatgttggg  accaaggga  2460
aacggtttg  aatagttga  gaccttgat  tttaattca  ttccaccag  cacttgtag  2520
tttatgcag  ttccaatcc  cttttctca  ttttaagtt  attacttac  tgtatatat  2580
ttgaaatta  tttgaacct  cgtatttgg  acatgatgg  ttataaatt  taactttc  2638



<210> 3142
<211> 173
<212> PRT
<213> Rattus norvegicus
<308> NP_113767
<400> 3142

Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Thr Tyr Lys Asn 
  1               5                  10                  15
Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Asn Lys 
             20                  25                  30
Phe Ile Glu Glu Leu Lys Lys Tyr Gly Val Thr Thr Ile Val Arg Val 
         35                  40                  45
Cys Glu Ala Thr Tyr Asp Thr Thr Leu Val Glu Lys Glu Gly Ile His 
     50                  55                  60
Val Leu Asp Trp Pro Phe Asp Asp Gly Ala Pro Pro Ser Asn Gln Ile 
 65                  70                  75                  80
Val Asp Asp Trp Leu Ser Leu Val Lys Ile Lys Phe Arg Glu Glu Pro 
                 85                  90                  95
Gly Cys Cys Ile Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro 
             100                105                110
Val Leu Val Ala Leu Ala Leu Ile Glu Gly Gly Met Lys Tyr Glu Asp 
         115                120                125
Ala Val Gln Phe Ile Arg Gln Lys Arg Arg Gly Ala Phe Asn Ser Lys 
     130                135                140
Gln Leu Leu Tyr Leu Glu Lys Tyr Arg Pro Lys Met Arg Leu Arg Phe 
 145                150                155                160
Lys Asp Ser Asn Gly His Arg Asn Asn Cys Cys Ile Gln 
                 165                170



<210> 3143
<211> 2200
<212> DNA
<213> Homo sapiens
<308> U48296
<400> 3143

cgggattac  gccaggcac  gcacgacct  tatgcagac  agtgaactg  agaaactga  60
tactgctcc  ccaagaagc  cccataaga  tggttatcc  ggacacaga  gtgttgaat  120
gaaatccac  gagcatttt  caagagttc  gacctggat  gggtaaacc  cagtgcact  180
cttttctgt  ggcctcagt  ttactggat  gaagaattg  tgcttcttg  taggaggtt  240
atttcactt  tcattactt  caacttcat  ctcaaagca  tgagaattt  aagtggagt  300
tattgaagt  gacttcagt  tctttgcat  atttctgta  tcaattttt  taattattt  360
ataacccta  tgagtgttt  taactaaat  acatggctc  aatgaaccg  ccagctcct  420
tggaagtca  atacaagaa  atgagattt  ttattacac  caatccaac  aatgcgacc  480
taaacaaat  tatagagga  cttaagaag  atggagtta  cacaatagt  agagtatgt  540
aagcaactt  tgacactac  cttgtggag  aagaaggta  ccatgttct  gattggcct  600
ttgatgatg  tgcaccacc  tccaaccag  ttgttgatg  ctggttaag  cttgtgaaa  660
ttaagtttc  tgaagaacc  ggttgttgt  ttgctgttc  ttgcgttgc  ggccttggg  720
gagctccag  acttgttgc  ctagcatta  ttgaaggtg  aatgaaata  gaagatgca  780
tacaattca  aagacaaaa  cggcgtgga  cttttaaca  caagcaact  ctgtatttg  840
agaagtatc  tcctaaaat  cggctgcgt  tcaaagatt  caacggtca  agaaacaac  900
gttgcattc  ataaaattg  ggtgcctaa  gctactgga  gtggaactt  agatagggc  960
taatttgtt  tacatatta  ccaacatgt  ggcttagta  gtctaatga  gcttccata  1020
gagtattga  aggcagttt  accaggcct  aagctagac  gatttggca  cctctgtat  1080
tgggttaca  tcaacctat  tggatactt  gcaaaagat  cttgctgtc  gcatataaa  1140
tgtgcttgt  atttgtatc  attgacctt  ccccaaatc  tgcagtatt  agttatgac  1200
tgttaaatc  attcccatg  cagaatctt  tcaatacat  agaaattta  gaagattag  1260
tgccaaaat  cccagcaca  tacttgtat  tttttagta  catacagaa  taaaatccc  1320
ggaactatg  acactagac  ttatgtggt  tattccttc  atcatttca  acattgaaa  1380
tagggccta  atggttatt  gcctgctca  tttatgttt  catctccca  attcatacc  1440
atatacgtc  ggtttgctt  accattgat  ttttttttt  ttaccaagt  ttacagtga  1500
tattttacg  gtttccatg  atctcactt  gtgctgtat  aaaaaaacc  ccattttga  1560
aatctacgt  gtacagaag  acatgtctt  aatgtcttc  gacaaaaaa  ccttacatt  1620
atttaatgt  tgcactctg  ggtgcaact  aacagggag  gcctgagaa  agaatggga  1680
ggggctatt  attattttt  agcaaaatg  tgcctttgt  ttgtgcaaa  atgtagaat  1740
tgctcttta  tctagtaaa  tattttttt  aaaggtaga  atgctttgt  attgtaatc  1800
taaacttcc  gaaattctt  taatttttt  ccatactta  cagaagtgt  tttaccaac  1860
tatttttgt  tgaaagtgt  atttttttt  tccttccca  cctctcttg  aaaaaaaga  1920
atgggtttc  gctaatgaa  tgagcagag  tctaatatt  tatatgcct  ttgagctgt  1980
taagttaat  tttgatact  gacaatttg  tttattatg  aattgataa  atggtgatg  2040
gtattaatg  tagttcaac  atatattta  actgtctgg  gatgtgtgg  tatagttct  2100
tgggagaaa  aattttgtc  gtgttcacc  gcttgtaaa  acttagtgc  agagctgaa  2160
catctaaat  aataatgac  tgcatttat  atcattgaaa  2200



<210> 3144
<211> 174
<212> PRT
<213> Homo sapiens
<308> U48296
<400> 3144

Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Thr Tyr Lys Asn 
  1               5                  10                  15
Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Asn Lys 
             20                  25                  30
Phe Ile Glu Glu Leu Lys Lys Tyr Gly Val Thr Thr Ile Val Arg Val 
         35                  40                  45
Cys Glu Ala Thr Tyr Asp Thr Thr Leu Val Glu Lys Glu Gly Ile His 
     50                  55                  60
Val Leu Asp Trp Pro Phe Asp Asp Gly Ala Pro Pro Ser Asn Gln Ile 
 65                  70                  75                  80
Val Asp Asp Trp Leu Ser Leu Val Lys Ile Lys Phe Arg Glu Glu Pro 
                 85                  90                  95
Gly Cys Cys Ile Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro 
             100                105                110
Val Leu Val Ala Leu Ala Leu Ile Glu Gly Gly Met Lys Tyr Glu Asp 
         115                120                125
Ala Val Gln Phe Ile Arg Gln Lys Arg Arg Gly Ala Phe Asn Ser Lys 
     130                135                140
Gln Leu Leu Tyr Leu Glu Lys Tyr Arg Pro Lys Met Arg Leu Arg Phe 
 145                150                155                160
Lys Asp Ser Asn Gly His Arg Asn Asn Cys Cys Ile Gln Ter 
                 165                170



<210> 3145
<211> 6878
<212> DNA
<213> Rattus norvegicus
<308> L28801
<400> 3145

gccggggct  ctaactgaa  aggccatgg  cgcgctcga  tcgttgttg  acgaggtgg  60
cctggaggg  ctcgacggc  tgtgcctgc  cgcgctgtg  agccgcctg  aatcccgct  120
gcctgcctt  cctttgccg  tggaaccct  cacgcagga  tttctgtgg  gggccttag  180
cacgcaccc  ggcatcagt  tctacgagg  gccgcgaga  cgacctgac  tgcagctcc  240
agaccgata  gaagaaatc  acttggaaa  tggaatttt  gagtccagg  gggacccag  300
cactctgga  gatgtctac  ccattcata  gatcttaga  aataaggat  gcatccagg  360
ctcctgccg  tactttaag  agagaaagg  catcaccag  agcatcagg  gcaagtgtt  420
gcagcctcg  tgtacaatg  tagaagcct  cagcaggtg  ggtaagaag  tcatcattg  480
ggcttccca  gacatgcga  accgggcct  gataggcct  gagggggat  ctgatctga  540
gcttcctga  ttctcctac  gcattttgg  gcggttagg  cgatcgaga  ggcaagggg  600
gctgcaacg  gaccttcac  ccaccgctt  caaggtcga  gctgggaag  ttcattatc  660
caggaaaat  ttgaacaag  atgggctca  tacaatgca  tcacacgtg  tccgactgc  720
tactggagc  cagcaacac  ccatcctcc  cctccttaa  cggtttcat  tagacagga  780
gagcaagta  gacatcctc  tggagaagc  gtctatgat  ctgagcaca  ggagcaacc  840
gatcgagac  ctgggcaag  tgagggagg  gctgggact  tgtgaaagg  cgttcaagc  900
tctgtacca  tacatgctg  atgctgggc  ggccaaagt  gtgtccctt  ccttgcagg  960
gattcaccc  gagtgtggt  cctgtaaga  caagaaagg  actgatgtc  tggttcggt  1020
ccttaagct  ctgaaggag  tcaggcgaa  gatggaaga  gaccatgac  acgatgacg  1080
tgaagaggc  atctccaag  ctgtacctc  cgtggacat  gtgtttgag  gggacatgc  1140
cacgcagac  tacgagctc  ttgagcgca  aggaacgaa  ggaatttcc  aagctgaga  1200
ccgagttgc  atgaatgtg  gaaaactgg  agcaagaat  ctgtgtcgg  tccttcaga  1260
gttcaaggt  gtcaaggga  tcatggaag  tgaaggccg  cagaggacc  ccaagtaca  1320
ttcctgtgt  tttgcggag  agagtgact  gagccgcca  tatgcgcgt  aaaaggccc  1380
aggagagct  ctaaccact  tgagcctcg  ctcagtgca  gatgaatcc  tcatgcctg  1440
gggtgaaga  gccttcctc  ctgactccg  aagtgagga  gagagcagc  gcagtggca  1500
gcgtagggg  cgagggtcc  gggggcatt  aagagcctc  ggggatgct  ggcctggct  1560
tcggcctca  cactccact  cagccaagg  cgggtggaa  gtcctaaat  tgcacccat  1620
aaagaagcc  aaaagtgcc  ctgtggaaa  atcccgccg  agctctgct  gtagggatg  1680
cctggacac  agcagctca  ccgagctca  tataccctt  gaccctcac  gcatggaca  1740
tcacagtgg  gacatcgct  tgattgagg  ggtccggct  gataacccc  aggagggtg  1800
tggctccca  aagggcgga  ggcatggct  aggccagga  aagcctcac  aaacatacc  1860
actgctaaa  cgcagaaat  tgattatag  agctgtcac  aacctccgc  tgattgaga  1920
cctgttcac  attcagaag  tgatcatgg  ccaggagaa  caagagggt  tctccacca  1980
atgctgtaa  aagtccatt  tccgcttgg  gcggaacct  tctgaggag  gtctcttga  2040
attgtatag  actacagtc  ttcaagatg  catcaagaa  aaggtagac  tggtcgtgc  2100
cccttccat  gaccagaat  accctcttg  gagaagtgc  attgagcag  ttcgcttcc  2160
gatctccaa  tcaagcaca  caaacaggg  taaagttcc  ccggcccca  caccccaag  2220
ggaagcaga  gagggaaac  aagaaccag  ggtcccaag  agatcagca  actctgaag  2280
gaacacatc  tcgaagcca  aaagcacac  ggtgaaaaa  acagatgag  aaatgggca  2340
aaccccact  aagaattac  aacctgtca  agttcctgg  cttgggcgc  ccatagggt  2400
ccttcccaa  atgccacgc  ttcgggtga  gcacctgtt  ctgtggtac  tggtgtatg  2460
gcatcctgc  agccacact  gggaacagc  tactttcca  agtgagagg  aaacaggca  2520
gcaggagcc  agcagacca  gggtccagc  ctcctcagg  gatgactgg  actcctctg  2580
agccaaaaa  agcacagaa  gcagctcct  ggaggcaga  atggaactc  ccacagaga  2640
agtgtatgt  gatgagatc  catggatgc  ctacgtccc  cccatcccc  tccacagag  2700
cttcggctt  ggctgggct  ttgtcagtg  cattcttct  tgccttccc  tctccatct  2760
tgtccaagt  gttcaagtc  gctacaagg  ggataacct  gaggatttt  tgaatgacc  2820
tctgaagaa  cacacactg  tccgcttcc  ccctaggca  atccggcag  agctactgt  2880
taagaggcg  tatattttc  cggtggtgg  gaacctgca  cggctgtgc  acatggggc  2940
gctacagtt  ggacccaca  agaagtttc  ggataaaga  caggtcttt  ttttcctga  3000
gaagaatgc  gtcattgtg  acaccacca  ctgtgaccc  cattacaac  tggcccaca  3060
cagccggcc  tttgagaga  gtctctacg  cttggattc  atgcaggat  tggaaagct  3120
ctggtttga  ctgcagtgt  tctgcctaa  caccccact  ggtgtggtg  gttgtccat  3180
tgcacagaa  atctgccct  atccgggca  tgacccaga  ggcagcttg  ggaaggagc  3240
agagagcgc  atggacaag  acaacctag  gcgcaagtg  gccatgctg  agtatacca  3300
ggggagccg  gaagttgtg  atgaaggct  agtccctgg  gatggactg  gagctgctg  3360
gctggactc  agcttctat  cacacctga  gcgcaactg  gtctggacc  gctatatca  3420
caacaaagc  agaaagaac  acacctccg  aaatgggct  acaggaaga  tccagactt  3480
cctgtctaa  cgcccaatg  cacttgggt  tggaggcag  ggccgtctg  ctctctggt  3540
agaggggaa  gctgatgct  agctctgtg  tgacaaaga  gaacacttt  aactggacc  3600
agaacctac  cctggcagg  accgaaaag  gcgtggggg  aagagtcag  agcggaagc  3660
gctgaagaa  gagcccatc  ggaagacca  gcgaaggag  agaggagag  atccagaag  3720
caaaagcaa  aaactacgc  accaagatg  ggctgacca  aacgccctc  ggatgatga  3780
ccggcttcg  gtttcttgg  ccatgcagg  ggatgggtt  ctaatgctc  gccgaattg  3840
cagcaatgt  ctcaacacc  aggtgaaag  accatttgt  acctggcag  tcgtgcgtg  3900
cattttgca  gctaccttt  aagagtctt  ggataaaac  tctcactcg  ttggacgaa  3960
agctcgcta  atagtcaaa  atccccagg  ctttatgaa  tacaaagtc  gcctggcag  4020
agtgtacca  gataaggca  tcgttggag  tttcatgag  cggaaggat  actacgaag  4080
cccaaaggt  tgtgccaag  agtttaaag  atttgtgga  aagctgaaa  agaagttca  4140
ctctggcct  aggaacccc  accttgaga  cccagacac  ctgcaggaa  tctttgcca  4200
ataccgggt  ttggcaatc  gagatgaaa  ggaccgtgt  aggaaggag  atgaactga  4260
tagtgtgga  gacatccac  tcctggtgc  acagaacct  atccagagc  cactgtccc  4320
ctctaacag  cagtccaac  cttgccagt  cttccagat  ttccgcctc  accgggagt  4380
ccgggagcc  gtgctggtg  gggccttca  ggagtgcca  aagaggagc  tggtcaacc  4440
acgccgtgt  agccactcc  agggtccca  gaagaaccg  gctgtgccc  ttgtgccca  4500
gtcctacca  ctctcccag  catactaca  gcttttcac  tggcgattt  ccaccaccg  4560
ctgcaccga  tccttccag  tctatgaca  actacgggc  aacggcata  tagaccagc  4620
tgatcattt  tctttcaag  acatggata  caatgaccc  tcaagtgac  tggtggcgt  4680
ttctttgga  agccctgga  gacactgtg  gacagccct  gccctcttc  ccttgggcc  4740
cctctctgt  gatgtccga  tcccagagc  gattgtggt  gtagacagc  ccatggtgg  4800
gagtgaggt  atgaagagc  tggggaaag  tggcggctt  gatgatgat  atgaggagg  4860
agacctgga  gaaggttca  ggaccaagc  tcagagtgt  gaagtaaag  cccatcagg  4920
ctcacacac  aagtacctg  tgatgagag  ttactacac  gtgcctggc  tggtcagca  4980
gcgcaacct  aaccccaat  acagcattg  ggtcaattc  tgccaggtt  aattccgac  5040
gcgcaatac  cctgcaccc  cccatcttg  gcccactgg  cccacagcc  caccgctag  5100
agagctcca  gctggccct  cctgcctcc  tgcctcctt  accagcctg  tggatccac  5160
gctgcacac  cgctgccca  aagagtttg  ccaccagat  gcacagtct  ggtacagcc  5220
tgaggacgt  gctgcgtcc  tagagatcc  gcaggctgt  gcagctgct  actgcttcg  5280
ggttgacag  gagaagctg  gcagacagt  ctctgcctt  gagaagata  cggacaagc  5340
caccaggac  ttcctggac  atatccagg  cctcttgga  cagcaacaa  tcatggaag  5400
tggaggcaa  actgtgcgc  tagtggcca  ggcctctgc  cagccctgg  tcctgcctt  5460
agtgcgtct  aaagatgtg  aaatagaca  caaggcctc  ggggatgac  gccaatcta  5520
actccctgc  gggtcttcc  tcgaagacc  cacctctga  ggtgcacca  ttcctccag  5580
cagctccaa  ggcactaaa  agcgcccct  ctgctctat  cagagccct  aaactgatg  5640
tgaggaagc  acaaggctc  ctgccaaga  gcccacatt  caagatgtc  gtgtggctg  5700
cagtcctag  cctggaaca  aagagcaga  agaggccca  gctcagttt  cagctcctg  5760
agatgcagg  gcagagggc  ccaggcagg  gagccaaga  agtgttggt  tctcaggcc  5820
agagcagct  ggctgtgag  tccagcttc  agaaaattc  gaagacccc  gaggactta  5880
agagagcaa  atggcccag  tagcatggg  gagcggctg  gaaagagta  gttttgtcg  5940
tcgcccatg  cgtggtgtg  acgggcgcc  gaacatgcc  gtgtgcaaa  gcatgatgg  6000
agccgtgct  taccacatc  tgtcaaggc  cggtgttcc  gagagctgc  tgctacagt  6060
ctaccaggg  gtcctacag  ctgttgctg  gcttgagct  ctccggggc  tagagtctc  6120
cggctgtat  cagaagcgg  tgctgaaga  gccagcgag  gtctcactc  tctccaggc  6180
tgtggtgga  ggcctaggt  aggccagtg  ggccgaggc  ctctcctgt  aggggagca  6240
tgtcacctt  tatgaacct  ctctggact  taccatccg  ctgggccgt  tcttccccc  6300
tgacatcaa  tggaaacaa  gtggatcca  ttatagatg  gtcccaggc  agcagagga  6360
cctctgccc  tgcttaatt  ttccgcctg  actgtccca  gagccccgt  cttcacaca  6420
ctgttacca  agctcggcc  agcctagca  aggtgtagc  actagcagg  gacttcagt  6480
ccctctgct  tcggctgct  ttggtccca  gtgcccagc  ttcctgcag  cctgtgtcc  6540
gccctggac  caggctcta  catcagcag  atctgcaag  gatgttgtt  agggagcag  6600
ctgatgacc  agccctgag  cacctcaca  gcaccacac  attcagact  agaggaaga  6660
acatcacag  tgtacctgg  agagtctgc  cctcttaag  tagggcatc  caacttggc  6720
tgaactgag  tcaggtctc  agctcccaa  ggcccctcc  gccagaagc  aggcctgta  6780
gttttgctt  tgtttttgt  ttattttgc  ctcttttca  tagatacaa  cccctggca  6840
gtatttatt  attttttaa  taaagtaag  tgaaatgc  6878



<210> 3146
<211> 2149
<212> PRT
<213> Rattus norvegicus
<308> L28801
<400> 3146

Met Asp Ala Leu Glu Ser Leu Leu Asp Glu Val Ala Leu Glu Gly Leu 
  1               5                  10                  15
Asp Gly Leu Cys Leu Pro Ala Leu Trp Ser Arg Leu Glu Ser Arg Ser 
             20                  25                  30
Pro Ala Phe Pro Leu Pro Leu Glu Pro Tyr Thr Gln Glu Phe Leu Trp 
         35                  40                  45
Arg Ala Leu Val Thr His Pro Gly Ile Ser Phe Tyr Glu Glu Pro Arg 
     50                  55                  60
Glu Arg Pro Asp Leu Gln Leu Gln Asp Arg Tyr Glu Glu Ile Asp Leu 
 65                  70                  75                  80
Glu Thr Gly Ile Leu Glu Ser Arg Arg Asp Pro Val Thr Leu Glu Asp 
                 85                  90                  95
Val Tyr Pro Ile His Met Ile Leu Glu Asn Lys Asp Gly Ile Gln Gly 
             100                105                110
Ser Cys Arg Tyr Phe Lys Glu Arg Lys Asp Ile Thr Ser Ser Ile Arg 
         115                120                125
Ser Lys Cys Leu Gln Pro Arg Cys Thr Met Val Glu Ala Phe Ser Arg 
     130                135                140
Trp Gly Lys Lys Leu Ile Ile Val Ala Ser Gln Asp Met Arg Tyr Arg 
 145                150                155                160
Ala Leu Ile Gly Leu Glu Gly Asp Pro Asp Leu Lys Leu Pro Asp Phe 
                 165                170                175
Ser Tyr Cys Ile Leu Glu Arg Leu Gly Arg Ser Arg Trp Gln Gly Glu 
             180                185                190
Leu Gln Arg Asp Leu His Thr Thr Ala Phe Lys Val Asp Ala Gly Lys 
         195                200                205
Leu His Tyr His Arg Lys Ile Leu Asn Lys Asn Gly Leu Ile Thr Met 
     210                215                220
Gln Ser His Val Ile Arg Leu Pro Thr Gly Ala Gln Gln His Ser Ile 
 225                230                235                240
Leu Leu Leu Leu Asn Arg Phe His Val Asp Arg Arg Ser Lys Tyr Asp 
                 245                250                255
Ile Leu Met Glu Lys Leu Ser Met Met Leu Ser Thr Arg Ser Asn Gln 
             260                265                270
Ile Glu Thr Leu Gly Lys Leu Arg Glu Glu Leu Gly Leu Cys Glu Arg 
         275                280                285
Thr Phe Lys Arg Leu Tyr Gln Tyr Met Leu Asn Ala Gly Leu Ala Lys 
     290                295                300
Val Val Ser Leu Pro Leu Gln Glu Ile His Pro Glu Cys Gly Pro Cys 
 305                310                315                320
Lys Thr Lys Lys Gly Thr Asp Val Met Val Arg Cys Leu Lys Leu Leu 
                 325                330                335
Lys Glu Phe Arg Arg Lys Met Glu Asp Asp His Asp Asp Asp Asp Asp 
             340                345                350
Glu Glu Ala Ile Ser Lys Ala Val Pro Pro Val Asp Ile Val Phe Glu 
         355                360                365
Arg Asp Met Leu Thr Gln Thr Tyr Glu Leu Ile Glu Arg Arg Gly Thr 
     370                375                380
Lys Gly Ile Ser Gln Ala Glu Ile Arg Val Ala Met Asn Val Gly Lys 
 385                390                395                400
Leu Glu Ala Arg Met Leu Cys Arg Leu Leu Gln Arg Phe Lys Val Val 
                 405                410                415
Lys Gly Phe Met Glu Asp Glu Gly Arg Gln Arg Thr Thr Lys Tyr Ile 
             420                425                430
Ser Cys Val Phe Ala Glu Glu Ser Asp Leu Ser Arg Gln Tyr Ala Arg 
         435                440                445
Glu Lys Ala Arg Gly Glu Leu Leu Thr Thr Val Ser Leu Ala Ser Val 
     450                455                460
Gln Asp Glu Ser Leu Met Pro Glu Gly Glu Glu Ala Phe Leu Ser Asp 
 465                470                475                480
Ser Glu Ser Glu Glu Glu Ser Ser Cys Ser Gly Lys Arg Arg Gly Arg 
                 485                490                495
Gly Ser Arg Gly His Ser Arg Ala Ser Gly Asp Ala Gly Pro Gly Ser 
             500                505                510
Arg Pro His His Ser Thr Pro Ala Lys Gly Gly Trp Lys Val Leu Asn 
         515                520                525
Leu His Pro Leu Lys Lys Pro Lys Ser Ala Ala Val Glu Arg Ser Arg 
     530                535                540
Arg Ser Ser Ala Cys Arg Asp Gly Leu Asp Thr Ser Ser Ser Ser Glu 
 545                550                555                560
Leu Asn Ile Pro Phe Asp Pro His Ser Met Asp Ser His Ser Gly Asp 
                 565                570                575
Ile Ala Val Ile Glu Glu Val Arg Leu Asp Asn Pro Lys Glu Gly Gly 
             580                585                590
Gly Ser Gln Lys Gly Gly Arg His Gly Ser Gly Gln Asp Lys Pro His 
         595                600                605
Lys Thr Tyr Arg Leu Leu Lys Arg Arg Asn Leu Ile Ile Glu Ala Val 
     610                615                620
Thr Asn Leu Arg Leu Ile Glu Ser Leu Phe Thr Ile Gln Lys Met Ile 
 625                630                635                640
Met Asp Gln Glu Lys Gln Glu Gly Val Ser Thr Lys Cys Cys Lys Lys 
                 645                650                655
Ser Ile Ile Arg Leu Val Arg Asn Leu Ser Glu Glu Gly Leu Leu Arg 
             660                665                670
Leu Tyr Arg Thr Thr Val Ile Gln Asp Gly Ile Lys Lys Lys Val Asp 
         675                680                685
Leu Val Val His Pro Ser Met Asp Gln Asn Asp Pro Leu Val Arg Ser 
     690                695                700
Ala Ile Glu Gln Val Arg Phe Arg Ile Ser Asn Ser Ser Thr Ala Asn 
 705                710                715                720
Arg Val Lys Val Pro Pro Ala Pro Ala Pro Gln Glu Glu Ala Glu Glu 
                 725                730                735
Gly Asn Gln Glu Pro Glu Val Pro Ser Arg Ser Ala Asp Ser Glu Ala 
             740                745                750
Asn Thr Ser Ser Lys Pro Glu Ser Thr Arg Val Lys Lys Thr Asp Glu 
         755                760                765
Lys Met Gly Ile Thr Pro Leu Lys Asn Tyr Lys Pro Val Ile Val Pro 
     770                775                780
Gly Leu Gly Arg Ser Ile Gly Phe Leu Pro Lys Met Pro Arg Leu Arg 
 785                790                795                800
Val Met His Leu Phe Leu Trp Tyr Leu Val Tyr Gly His Pro Ala Ser 
                 805                810                815
His Thr Gly Glu Gln Pro Thr Phe His Ser Glu Arg Lys Thr Gly Lys 
             820                825                830
Gln Glu Pro Ser Arg Pro Gly Val Gln Pro Ser Ser Gly Asp Asp Trp 
         835                840                845
Asp Ser Ser Glu Ala Lys Asn Ser Thr Glu Ser Ser Ser Trp Glu Ala 
     850                855                860
Glu Met Glu Leu Ser Thr Glu Arg Val Tyr Val Asp Glu Ile Ser Trp 
 865                870                875                880
Met Arg Tyr Val Pro Pro Ile Pro Ile His Arg Asp Phe Gly Phe Gly 
                 885                890                895
Trp Ala Leu Val Ser Asp Ile Leu Leu Cys Leu Pro Leu Ser Ile Phe 
             900                905                910
Val Gln Val Val Gln Val Ser Tyr Lys Val Asp Asn Leu Glu Asp Phe 
         915                920                925
Leu Asn Asp Pro Leu Lys Lys His Thr Leu Ile Arg Phe Leu Pro Arg 
     930                935                940
His Ile Arg Gln Gln Leu Leu Tyr Lys Arg Arg Tyr Ile Phe Ser Val 
 945                950                955                960
Val Glu Asn Leu Gln Arg Leu Cys Tyr Met Gly Leu Leu Gln Phe Gly 
                 965                970                975
Pro Thr Glu Lys Phe Gln Asp Lys Asp Gln Val Phe Val Phe Leu Lys 
             980                985                990
Lys Asn Ala Val Ile Val Asp Thr Thr Ile Cys Asp Pro His Tyr Asn 
         995                1000                1005
Leu Ala His Ser Ser Arg Pro Phe Glu Arg Arg Leu Tyr Val Leu Asp 
     1010                1015                1020
Ser Met Gln Asp Val Glu Ser Tyr Trp Phe Asp Leu Gln Cys Ile Cys 
 1025                1030                1035                1040
Leu Asn Thr Pro Leu Gly Val Val Arg Cys Pro Cys Ala Gln Lys Ile 
                 1045                1050                1055
Cys Pro Asp Pro Gly Ser Asp Pro Glu Gly Ser Leu Arg Lys Glu Gln 
             1060                1065                1070
Glu Ser Ala Met Asp Lys His Asn Leu Glu Arg Lys Cys Ala Met Leu 
         1075                1080                1085
Glu Tyr Thr Thr Gly Ser Arg Glu Val Val Asp Glu Gly Leu Val Pro 
     1090                1095                1100
Gly Asp Gly Leu Gly Ala Ala Gly Leu Asp Ser Ser Phe Tyr Ala His 
 1105                1110                1115                1120
Leu Lys Arg Asn Trp Val Trp Thr Ser Tyr Ile Ile Asn Lys Ala Arg 
                 1125                1130                1135
Lys Asn Asn Thr Ser Glu Asn Gly Leu Thr Gly Arg Leu Gln Thr Phe 
             1140                1145                1150
Leu Ser Lys Arg Pro Met Pro Leu Gly Ser Gly Gly Ser Gly Arg Leu 
         1155                1160                1165
Pro Leu Trp Ser Glu Gly Lys Ala Asp Ala Glu Leu Cys Ala Asp Lys 
     1170                1175                1180
Glu Glu His Phe Glu Leu Asp Arg Glu Pro Thr Pro Gly Arg Asn Arg 
 1185                1190                1195                1200
Lys Val Arg Gly Gly Lys Ser Gln Lys Arg Lys Arg Leu Lys Lys Glu 
                 1205                1210                1215
Pro Ile Arg Lys Thr Lys Arg Arg Arg Arg Gly Glu His Pro Glu Ala 
             1220                1225                1230
Lys Ser Lys Lys Leu Arg Tyr Gln Asp Glu Ala Asp Gln Asn Ala Leu 
         1235                1240                1245
Arg Met Met Thr Arg Leu Arg Val Ser Trp Ser Met Gln Glu Asp Gly 
     1250                1255                1260
Leu Leu Met Leu Cys Arg Ile Ala Ser Asn Val Leu Asn Thr Lys Val 
 1265                1270                1275                1280
Lys Gly Pro Phe Val Thr Trp Gln Val Val Arg Asp Ile Leu His Ala 
                 1285                1290                1295
Thr Phe Glu Glu Ser Leu Asp Lys Thr Ser His Ser Val Gly Arg Arg 
             1300                1305                1310
Ala Arg Tyr Ile Val Lys Asn Pro Gln Ala Phe Met Asn Tyr Lys Val 
         1315                1320                1325
Cys Leu Ala Glu Val Tyr Gln Asp Lys Ala Leu Val Gly Asp Phe Met 
     1330                1335                1340
Ser Arg Lys Asp Asn Tyr Glu Asp Pro Lys Val Cys Ala Lys Glu Phe 
 1345                1350                1355                1360
Lys Glu Phe Val Glu Lys Leu Lys Glu Lys Phe Ser Ser Gly Leu Arg 
                 1365                1370                1375
Asn Pro Asn Leu Glu Ile Pro Asp Thr Leu Gln Glu Leu Phe Ala Lys 
             1380                1385                1390
Tyr Arg Val Leu Ala Ile Gly Asp Glu Lys Asp Arg Val Arg Lys Glu 
         1395                1400                1405
Asp Glu Leu Asn Ser Val Glu Asp Ile His Phe Leu Val Leu Gln Asn 
     1410                1415                1420
Leu Ile Gln Ser Thr Leu Ser Leu Ser Asn Ser Gln Ser Asn Ser Cys 
 1425                1430                1435                1440
Gln Ser Phe Gln Ile Phe Arg Leu Tyr Arg Glu Phe Arg Glu Pro Val 
                 1445                1450                1455
Leu Val Arg Ala Phe Met Glu Cys Gln Lys Arg Ser Leu Val Asn Arg 
             1460                1465                1470
Arg Arg Val Ser His Ser Gln Gly Pro Lys Lys Asn Arg Ala Val Pro 
         1475                1480                1485
Phe Val Pro Met Ser Tyr Gln Leu Ser Gln Ser Tyr Tyr Lys Leu Phe 
     1490                1495                1500
Thr Trp Arg Phe Pro Thr Thr Val Cys Thr Glu Ser Phe Gln Phe Tyr 
 1505                1510                1515                1520
Asp Arg Leu Arg Ala Asn Gly Ile Leu Asp Gln Pro Asp His Phe Ser 
                 1525                1530                1535
Phe Lys Asp Met Asp Ser Asn Asp Pro Ser Ser Asp Leu Val Ala Phe 
             1540                1545                1550
Ser Leu Asp Ser Pro Gly Gly His Cys Val Thr Ala Leu Ala Leu Phe 
         1555                1560                1565
Ser Leu Gly Leu Leu Ser Val Asp Val Arg Ile Pro Glu Gln Ile Val 
     1570                1575                1580
Val Val Asp Ser Ser Met Val Glu Ser Glu Val Met Lys Ser Leu Gly 
 1585                1590                1595                1600
Lys Asp Gly Gly Leu Asp Asp Asp Asp Glu Glu Glu Asp Leu Asp Glu 
                 1605                1610                1615
Gly Ser Gly Thr Lys Arg Gln Ser Val Glu Val Lys Ala His Gln Ala 
             1620                1625                1630
Ser His Thr Lys Tyr Leu Leu Met Arg Gly Tyr Tyr Thr Val Pro Gly 
         1635                1640                1645
Met Val Ser Thr Arg Asn Leu Asn Pro Asn Asp Ser Ile Val Val Asn 
     1650                1655                1660
Ser Cys Gln Val Lys Phe Arg Leu Arg Asn Thr Pro Ala Pro Thr His 
 1665                1670                1675                1680
Leu Gly Pro Thr Gly Pro Thr Ala Thr Pro Leu Glu Glu Leu Gln Ala 
                 1685                1690                1695
Gly Pro Ser Cys Leu Pro Ala Ser Phe Thr Ser Leu Val Asp Pro Gln 
             1700                1705                1710
Leu His Thr Arg Cys Pro Glu Glu Phe Ala His Gln Met Ala Gln Ser 
         1715                1720                1725
Gly Tyr Ser Pro Glu Asp Val Ala Ala Ser Leu Glu Ile Leu Gln Ala 
     1730                1735                1740
Val Ala Ala Ala Asp Cys Phe Gly Val Asp Arg Glu Lys Leu Ser Arg 
 1745                1750                1755                1760
Gln Phe Ser Ala Leu Glu Lys Ile Ala Asp Lys Arg Thr Arg Thr Phe 
                 1765                1770                1775
Leu Asp Tyr Ile Gln Asp Leu Leu Glu Gln Gln Gln Val Met Glu Val 
             1780                1785                1790
Gly Gly Asn Thr Val Arg Leu Val Ala Met Ala Ser Ala Gln Pro Trp 
         1795                1800                1805
Leu Leu Pro Ser Val Arg Leu Lys Asp Val Glu Ile Asp Thr Lys Ala 
     1810                1815                1820
Ser Gly Asp Asp Ser Gln Ser Arg Leu Pro Ala Gly Ser Ser Ile Glu 
 1825                1830                1835                1840
Asp His Thr Ser Glu Gly Ala Pro Ile Pro Pro Val Ser Ser Asn Gly 
                 1845                1850                1855
Thr Lys Lys Arg Pro Tyr Cys Ser Ile Gln Ser Pro Glu Thr Asp Ala 
             1860                1865                1870
Glu Glu Ala Thr Arg Leu Pro Ala Lys Lys Pro Thr Leu Gln Asp Val 
         1875                1880                1885
Cys Val Ala Ala Ser Pro Arg Pro Gly Thr Glu Glu Gln Thr Glu Ala 
     1890                1895                1900
Gln Ala Gln Phe Ala Ala Pro Glu Asp Ala Gly Ala Glu Gly Pro Arg 
 1905                1910                1915                1920
Gln Glu Ser Gln Glu Ser Val Gly Val Ser Gly Leu Glu Gln Leu Gly 
                 1925                1930                1935
Cys Glu Phe Gln Leu Pro Glu Asn Ser Glu Asp Pro Arg Gly Leu Thr 
             1940                1945                1950
Glu Ser Asn Met Ala Gln Val Ala Trp Glu Ser Gly Cys Glu Arg Val 
         1955                1960                1965
Cys Phe Val Gly Arg Pro Trp Arg Gly Val Asp Gly Arg Leu Asn Met 
     1970                1975                1980
Pro Val Cys Lys Gly Met Met Glu Ala Val Leu Tyr His Ile Met Ser 
 1985                1990                1995                2000
Arg Pro Gly Val Pro Glu Ser Cys Leu Leu Gln Tyr Tyr Gln Gly Val 
                 2005                2010                2015
Leu Gln Pro Val Ala Val Leu Glu Leu Leu Arg Gly Leu Glu Ser Leu 
             2020                2025                2030
Gly Cys Ile Gln Lys Arg Met Leu Lys Lys Pro Ala Ser Val Ser Leu 
         2035                2040                2045
Phe Ser Arg Pro Val Val Glu Gly Leu Gly Gln Ala Ser Glu Ala Glu 
     2050                2055                2060
Ala Leu Ser Cys Gln Gly Ser Thr Val Thr Phe Tyr Glu Pro Thr Leu 
 2065                2070                2075                2080
Asp Cys Thr Ile Arg Leu Gly Arg Val Phe Pro His Asp Ile Asn Trp 
                 2085                2090                2095
Lys Gln Ser Gly Ser Ile Tyr Arg Cys Val Pro Gly Gln Gln Arg Ser 
             2100                2105                2110
Leu Cys Pro Cys Leu Ile Val Pro Pro Gly Leu Ser Gln Glu Pro Arg 
         2115                2120                2125
Pro Ser His Ser Cys Tyr Gln Ser Ser Ala Gln Pro Ser Thr Gly Val 
     2130                2135                2140
Ala Thr Ser Arg Ter 
 2145



<210> 3147
<211> 6996
<212> DNA
<213> Homo sapiens
<308> U02619
<400> 3147

atggaccaa  gcccttggc  gtgcgttgc  cacccccgg  gcgccgcga  tgaagtagc  60
atggacgcg  tggagtcgt  gttggacga  gtcgctctg  aggggctcg  tggcctgtg  120
ctgccagcg  tgtggagcc  gctggagac  cgagtgccg  ccttcccgc  gcctttgga  180
ccctgcacg  aggagtttc  ctggcgggc  ctcgccacg  acccgggca  cagcttcta  240
gaggagcct  gggagcgac  cgacctaca  ctccaggac  ggtatgaag  aattgattt  300
gaaactgga  ttttggagt  taggaggga  ccggtggct  tggaggatg  ctaccccat  360
catatgatc  tagagaata  ggatggcat  cagggctca  gccgctact  taaggagag  420
aaaaacatt  ccaatgaca  cagaaccaa  tccttgcag  ctcgctgta  aatggtgga  480
ccctttgac  ggtggggga  gaaactgat  atcggttcc  tcccagccc  tgcggtaca  540
gcccttgat  gcccaggag  gggatcccg  cctgaagct  cccgacttc  cctactgca  600
cctggaacg  ctaggccgg  ccaggtgca  ggggagctc  agcgagacc  tcacaccac  660
gctttcaag  ttgatgctg  gaagctgca  tatcacaga  aaattttga  caaaaacgg  720
ctgattaca  tgcagtccc  tgtgatccg  ttacccact  gagcccagc  acactcaat  780
ctcctccta  tgaaccggt  tcatgtgga  aggaggagc  aatacgaca  cctcatgga  840
aagctttcg  tcatgctga  cacacggac  aaccacata  agacgctgg  aaagctgag  900
gaagagctg  ggctgtgcg  aaggacgtt  aagcgtctg  accagtata  gctgaacgc  960
gggctagcc  aggtggtgt  tcttcgctt  caagagatc  accctgaat  tggaccttg  1020
aagacaaag  aagggaccg  cgtcatggt  cggtgcctc  agctgctga  ggaatttaa  1080
cggaatgac  atgatgatg  cgaggacga  gaggtcatc  ccaagacag  gcctccagt  1140
gacattgtg  tcgagcggg  tatgctcac  cagacctac  acctcattg  gcgcagagg  1200
acgaaagga  tttcccaag  tgaaatccg  gtggctatg  atgtgggaa  actagaagc  1260
agaatgctg  gccgacttc  tcaaagatt  aaagttgtc  agggattca  ggaagacga  1320
ggtcggcag  gaaccacca  gtacatttc  tgcgtgttt  cagaggaga  cgacctaag  1380
cggcagtac  aaagagaga  ggcccgcag  gagctcttg  ccaccgtga  cctggcgtc  1440
atgcaggag  agtcgcttc  gcctgaagg  gaggacacc  tcctctctg  gtcggacag  1500
gaggaggag  ggagcagca  caagcggag  ggcagaggg  cccagaaag  cacaagagc  1560
tctgcaaac  tccggccca  gacccagcc  catcactcc  ccccaacca  gggtgggtg  1620
aaagttgta  acctacacc  attgaaaaa  cagccgccc  ccttcccag  agctgctga  1680
gagagagcc  gccagagcc  tgccagcag  gacagcctc  tagatacca  cagcgtctc  1740
gaacccaac  tgtcctttg  ctcccactg  gcggacagc  acagtggtg  catagctgt  1800
atcgaggag  tccggatgg  aaacccaaa  gagagtagc  gttccctga  gactgggag  1860
cacagctca  gccaagaca  accacacga  acttaccga  tgctgaaac  caggaatct  1920
atcatagaa  ctgtcacca  tcttcgctt  atcgagagt  tattcacga  tcagaagat  1980
atcatggat  aggagaagc  ggaaggcgt  tccaccaag  gctgcaaga  gtccattgt  2040
cgcttggtg  ggaacctgt  tgaggaagg  ctcttgcga  tgtatcgga  cactgtcat  2100
caagatggc  tcaagaaga  ggtggatct  gtggtgcac  cgtccatgg  ccagaacga  2160
cctctagtg  gaagtgcca  cgagcaggt  cgcttccgg  tctccaatt  aagcacagc  2220
aacagggtt  aaacttccc  gcctccagt  ccccaaggg  aggcagaag  agacagtca  2280
ggaaaagag  gcccaagtg  atcagggga  tctcagctg  gtgcttcct  tagatcaga  2340
agtggacgg  tgaaaaaaa  tgataataa  atgggcata  ccccgctta  aaattatca  2400
cccattgta  ttcccggac  ggggcgttc  ctaggattt  tgcccaaaa  gcctcgcct  2460
cgggtggtc  acatgtttc  gtggtacct  atctacggg  accctgcca  caacaccgt  2520
gagaagcca  gcttcatca  tgaacggag  acgataaag  aggagtcag  cagggcagg  2580
gtccggccg  cctcctctg  aagtgcctg  gaggcctgc  ctgaagccc  atctaaagg  2640
agccaagat  gtgtcacct  ggaggctga  gtggagctt  ccacggaga  agtgtatgt  2700
gacgatgcc  cgtggatgc  ctacatccc  ccaatccca  tccacaggg  cttcggctt  2760
ggctgggct  tcgtcagcg  catcctcct  tgccttccc  tctccatct  catccagat  2820
gtgcaagtc  gctacaagg  ggacaacct  gaggaattt  tgaacgacc  gctgaagaa  2880
cacacgctg  tccgctttc  ccccaggcc  attcggcag  agcttctgt  caagaggcg  2940
tacattttt  cggtggtgg  gaaccttca  aggctgtgc  acatggggg  gctacagtt  3000
ggtcccacg  aaaagtttc  ggataaaga  caggtcttt  tcttcttga  gaagaatgc  3060
gtcattgtt  acactacca  ctgcgaccc  cattacaac  tgggccgca  gaggcggcc  3120
ttcgagagg  gcctctatg  cctgaactc  atgcaggat  tggaaaact  ctggtttga  3180
ctgcagtgc  tctgcctca  caccccact  ggcgtggtg  gctgcccgc  cgtcaggaa  3240
aacagcagc  cagaccagg  cagcgacga  gagggcagc  tgcagaagg  gcaggagag  3300
gccatggac  agcacaacc  ggagcgcaa  tgcgccatg  tggagtaca  cactggaag  3360
cgtgaggtg  tggatgaag  cttgatccc  ggagatggg  tgggtgccg  agggctcga  3420
tccagcttc  acggacacc  caagcgcaa  tggatctgg  ccagctaca  catcaacca  3480
gccaaaaag  agaacactg  cgcagagaa  ggactcaca  tgaggctcc  gacatttct  3540
tccaagcgc  caatgcccc  cagtgccag  ggcaacagc  ggttgaata  ttgggggga  3600
gcaagagta  gctccgagc  ctgtgctgg  tgggaagag  agtttgagg  ggaccgaga  3660
ccctcgctg  accgaaacc  gagagtgag  ggtgggaaa  gccagaagc  gaagcggct  3720
aagaaggac  ctgggaaga  gatcaagag  aagaagaaa  gagagttcc  aggagaaaa  3780
agcaaaagg  tgcgctacc  tgatgaagc  gaccagagt  ccctgcatc  gatgacgcg  3840
cttcgtgtc  cctggtcta  gcaggagga  gggctgctt  tgctgtgcc  cattgccag  3900
aatgtcctc  acaccaagg  gaagggtcc  tttgtcacc  ggcaggtgg  acgggacat  3960
ttgcatgcc  cgtttgaag  gtctttgga  aaaacatct  attcccttg  acgaagagc  4020
cgctacata  tcaaaaacc  acaggccta  ctcaactat  aagtgtgcc  ggccgaggt  4080
taccaggat  aagcacttg  tggagattt  atgaatcga  gaggtgact  tgatgaccc  4140
aaggtttgt  ccaacgagt  taaagaatt  gtggagaag  ttaaagaaa  gttcagttc  4200
gccctaagg  attctaacc  tgaaatccc  gacacactc  aggagctgt  cgccaggta  4260
cgagttttg  caattgggg  tgaaaaaga  caaaccagg  aagaggatg  acttaacag  4320
gtggatgac  tccactttc  ggtgcttca  aacctgatc  agagcacgc  ggccctctc  4380
gacagtcag  tgaagtcct  ccagtcatt  cagactttc  gcctctatc  ggagtacaa  4440
gaccacgtt  ttgtgaagg  cttcatgga  tgccagaag  ggagcttgg  caaccggcg  4500
cgggtcaac  acacgctgg  ccccaagaa  aaccgggcc  tccccttcg  gccaatgtc  4560
taccagcta  cccagacct  ctacaggat  tttacgtgg  gatttccaa  caccatctg  4620
acggagtca  tccagtttt  ggacagaat  cgggctgcc  gcaagttgg  ccagcctga  4680
cgtttctct  tcaaagacc  ggataataa  gagcccaca  acgacatgg  ggccttttc  4740
ctggacggc  ctggaggaa  ttgtgtggc  gtcctgacc  tcttctctc  gggcctcat  4800
tctgtggat  tcaggatcc  ggagcagat  atcgtggta  acagctcaa  ggtggagaa  4860
gaggtcatc  aaagcttgg  gaaggacgg  agcctggag  atgacgagg  tgaagagga  4920
gacttggac  aaggtgtag  gggcaagcg  cggagcatg  aggtgaaac  tgcgcaagc  4980
tcccacacc  actacctgc  gatgagggg  tactactcc  ccggcatcg  cagcacccg  5040
aacctcaac  ccaacgaca  cattgtggt  aactcctgc  agatgaagt  ccagctccg  5100
tgcacccct  tgcccgccc  gctcaggcc  gctgccgct  ctctggaag  gctaacaat  5160
ggaacctcc  gcctccctg  tacgttcac  aagctgata  acccccagg  aaacacctg  5220
agcttggag  agtttgtcc  ccagctgga  ctgtctggg  atagtcccg  agacctgac  5280
gctgccttg  agatcttgg  agccattat  gccacgggt  gttttggga  tgacaagga  5340
gagctgcgc  gacggttct  ggccttgga  aaggcaggt  gtgggcgca  caggacatt  5400
gcagattgc  tccaggccc  cctggagca  catcaggtg  tggaggtcg  tggcaacac  5460
gcgcgcctg  tagccatgg  ctctgcctg  ccttggctc  tgcactccg  gcggctgaa  5520
gacagagaa  acgccgaca  ccagagaga  gacccccag  ccagacccc  ggaggggtc  5580
tccagtgag  acagccccc  cgaggggca  gcacctcct  ctcacagcc  ccggggcac  5640
aagaggcgc  ccagctggg  cagtgagaa  ggggagacc  acgccgagg  cacccagat  5700
acccctgcc  agaggccag  gctccagga  tcaaatttg  cccccagcc  tgggcccgg  5760
gctgaagat  gggcagaag  ccaggcccc  tctccaccc  cagctcttg  agacaccgc  5820
gcagcggga  cagcacagg  agaccaaga  ggtgtcggt  agttcagtt  cccaggcca  5880
gagcagctg  gcggccagg  gcagcctcc  gagggctct  aagacccca  agggttcac  5940
gagagtttc  gagctgcca  catctccca  gcagcacgg  aaagggact  tgagagtgt  6000
tgcttcatc  gccggccgt  gcgtgtcgt  gatggccac  tgaaccttc  tgtatgcaa  6060
ggtatgatg  aggccatgc  gtaccacat  atgaccagg  ctggcatcc  cgagagctc  6120
ctgctgcgc  actaccagg  ggtcctgca  cccgtcgcc  tgctggagt  gctccaggg  6180
ctggagtcc  tcggctgca  ccggaagcg  tggctgaga  agccaaggc  tgtctcgct  6240
ttctctaca  ccgtggtgg  agaggtgga  gtgccctcc  gcctggacg  gagccccat  6300
gctttctat  agcccacct  ggactgtac  ctccggctg  gccgtgtgt  cccccacga  6360
gtcaactgg  acaagtgga  ccacctcta  gacccctgt  ggcgtcccc  ccctcccag  6420
caccgcctg  cacaccact  ctgcctggt  ctcggcaga  cccactgtg  cctggcctt  6480
ggtctgccg  gcctcctgc  gcaggggac  ggtgctttg  ccagagtca  agactgaca  6540
gtttcccac  gtactggaa  tctggaaag  ggggctccc  gacctgccc  tcccccagg  6600
tcttctggg  cttcccctt  ggaactggc  tcatcacac  gggagttgg  gcttcttgt  6660
tctgggtct  cagagtttg  cccgcctgt  cacacctca  attccagac  ctagccatc  6720
cggcaggat  tcctggctc  ttgagtgcc  aggtgccac  aagaggaag  gccttgtgg  6780
atacacctt  cagaatagg  atcggtgtg  cccgctgcg  ggggccccc  atgggggct  6840
tggcccctc  gcaggcagg  catcccaac  cctggctgg  actgaacca  ccagagcgg  6900
gcggctccc  tttcagcct  gtgagtcac  tggcaggcc  cagctgggc  ggctgtccg  6960
gtccctcag  ctggctggt  attccttgc  ggaggg  6996



<210> 3148
<211> 2110
<212> PRT
<213> Homo sapiens
<308> U02619
<400> 3148

Met Asp Ala Leu Glu Ser Leu Leu Asp Glu Val Ala Leu Glu Gly Leu 
  1               5                  10                  15
Asp Gly Leu Cys Leu Pro Ala Leu Trp Ser Arg Leu Glu Thr Arg Val 
             20                  25                  30
Pro Pro Phe Pro Leu Pro Leu Glu Pro Cys Thr Gln Glu Phe Leu Trp 
         35                  40                  45
Arg Ala Leu Ala Thr His Pro Gly Ile Ser Phe Tyr Glu Glu Pro Arg 
     50                  55                  60
Glu Arg Pro Asp Leu Gln Leu Gln Asp Arg Tyr Glu Glu Ile Asp Leu 
 65                  70                  75                  80
Glu Thr Gly Ile Leu Glu Ser Arg Arg Asp Pro Val Ala Leu Glu Asp 
                 85                  90                  95
Val Tyr Pro Ile His Met Ile Leu Glu Asn Lys Asp Gly Ile Gln Gly 
             100                105                110
Ser Cys Arg Tyr Phe Lys Glu Arg Lys Asn Ile Thr Asn Asp Ile Arg 
         115                120                125
Thr Lys Ser Leu Gln Pro Arg Cys Thr Met Val Glu Pro Phe Asp Arg 
     130                135                140
Trp Gly Lys Lys Leu Ile Ile Gly Ser Leu Pro Ala His Ala Val Gln 
 145                150                155                160
Ala Leu Asp Ser Pro Gly Gly Gly Ser Arg Pro Glu Ala Ala Arg Leu 
                 165                170                175
Leu Leu Leu His Pro Gly Thr Ala Arg Pro Val Gln Val Gln Gly Glu 
             180                185                190
Leu Gln Arg Asp Leu His Thr Thr Ala Phe Lys Val Asp Ala Gly Lys 
         195                200                205
Leu His Tyr His Arg Lys Ile Leu Asn Lys Asn Gly Leu Ile Thr Met 
     210                215                220
Gln Ser His Val Ile Arg Leu Pro Thr Gly Ala Gln Gln His Ser Ile 
 225                230                235                240
Leu Leu Leu Leu Asn Arg Phe His Val Asp Arg Arg Ser Lys Tyr Asp 
                 245                250                255
Ile Leu Met Glu Lys Leu Ser Val Met Leu Ser Thr Arg Thr Asn His 
             260                265                270
Ile Glu Thr Leu Gly Lys Leu Arg Glu Glu Leu Gly Leu Cys Glu Arg 
         275                280                285
Thr Phe Lys Arg Leu Tyr Gln Tyr Met Leu Asn Ala Gly Leu Ala Lys 
     290                295                300
Val Val Ser Leu Arg Leu Gln Glu Ile His Pro Glu Cys Gly Pro Cys 
 305                310                315                320
Lys Thr Lys Lys Gly Thr Asp Val Met Val Arg Cys Leu Lys Leu Leu 
                 325                330                335
Lys Glu Phe Lys Arg Asn Asp His Asp Asp Asp Glu Asp Glu Glu Val 
             340                345                350
Ile Ser Lys Thr Val Pro Pro Val Asp Ile Val Phe Glu Arg Asp Met 
         355                360                365
Leu Thr Gln Thr Tyr Asp Leu Ile Glu Arg Arg Gly Thr Lys Gly Ile 
     370                375                380
Ser Gln Ala Glu Ile Arg Val Ala Met Asn Val Gly Lys Leu Glu Ala 
 385                390                395                400
Arg Met Leu Cys Arg Leu Leu Gln Arg Phe Lys Val Val Lys Gly Phe 
                 405                410                415
Met Glu Asp Glu Gly Arg Gln Arg Thr Thr Lys Tyr Ile Ser Cys Val 
             420                425                430
Phe Ala Glu Glu Ser Asp Leu Ser Arg Gln Tyr Gln Arg Glu Lys Ala 
         435                440                445
Arg Ser Glu Leu Leu Thr Thr Val Ser Leu Ala Ser Met Gln Glu Glu 
     450                455                460
Ser Leu Leu Pro Glu Gly Glu Asp Thr Phe Leu Ser Glu Ser Asp Ser 
 465                470                475                480
Glu Glu Glu Arg Ser Ser Ser Lys Arg Arg Gly Arg Gly Ser Gln Lys 
                 485                490                495
Asp Thr Arg Ala Ser Ala Asn Leu Arg Pro Lys Thr Gln Pro His His 
             500                505                510
Ser Thr Pro Thr Lys Gly Gly Trp Lys Val Val Asn Leu His Pro Leu 
         515                520                525
Lys Lys Gln Pro Pro Ser Phe Pro Gly Ala Ala Glu Glu Arg Ala Cys 
     530                535                540
Gln Ser Leu Ala Ser Arg Asp Ser Leu Leu Asp Thr Ser Ser Val Ser 
 545                550                555                560
Glu Pro Asn Val Ser Phe Val Ser His Cys Ala Asp Ser Asn Ser Gly 
                 565                570                575
Asp Ile Ala Val Ile Glu Glu Val Arg Met Glu Asn Pro Lys Glu Ser 
             580                585                590
Ser Ser Ser Leu Lys Thr Gly Arg His Ser Ser Gly Gln Asp Lys Pro 
         595                600                605
His Glu Thr Tyr Arg Leu Leu Lys Arg Arg Asn Leu Ile Ile Glu Ala 
     610                615                620
Val Thr Asn Leu Arg Leu Ile Glu Ser Leu Phe Thr Ile Gln Lys Met 
 625                630                635                640
Ile Met Asp Gln Glu Lys Gln Glu Gly Val Ser Thr Lys Cys Cys Lys 
                 645                650                655
Lys Ser Ile Val Arg Leu Val Arg Asn Leu Ser Glu Glu Gly Leu Leu 
             660                665                670
Arg Leu Tyr Arg Thr Thr Val Ile Gln Asp Gly Ile Lys Lys Lys Val 
         675                680                685
Asp Leu Val Val His Pro Ser Met Asp Gln Asn Asp Pro Leu Val Arg 
     690                695                700
Ser Ala Ile Glu Gln Val Arg Phe Arg Ile Ser Asn Ser Ser Thr Ala 
 705                710                715                720
Asn Arg Val Lys Thr Ser Gln Pro Pro Val Pro Gln Gly Glu Ala Glu 
                 725                730                735
Glu Asp Ser Gln Gly Lys Glu Gly Pro Ser Gly Ser Gly Asp Ser Gln 
             740                745                750
Leu Ser Ala Ser Ser Arg Ser Glu Ser Gly Arg Met Lys Lys Ser Asp 
         755                760                765
Asn Lys Met Gly Ile Thr Pro Leu Arg Asn Tyr His Pro Ile Val Val 
     770                775                780
Pro Gly Leu Gly Arg Ser Leu Gly Phe Leu Pro Lys Met Pro Arg Leu 
 785                790                795                800
Arg Val Val His Met Phe Leu Trp Tyr Leu Ile Tyr Gly His Pro Ala 
                 805                810                815
Ser Asn Thr Val Glu Lys Pro Ser Phe Ile Ser Glu Arg Arg Thr Ile 
             820                825                830
Lys Gln Glu Ser Gly Arg Ala Gly Val Arg Pro Ser Ser Ser Gly Ser 
         835                840                845
Ala Trp Glu Ala Cys Ser Glu Ala Pro Ser Lys Gly Ser Gln Asp Gly 
     850                855                860
Val Thr Trp Glu Ala Glu Val Glu Leu Ala Thr Glu Thr Val Tyr Val 
 865                870                875                880
Asp Asp Ala Ser Trp Met Arg Tyr Ile Pro Pro Ile Pro Val His Arg 
                 885                890                895
Asp Phe Gly Phe Gly Trp Ala Leu Val Ser Asp Ile Leu Leu Cys Leu 
             900                905                910
Pro Leu Ser Ile Phe Ile Gln Ile Val Gln Val Ser Tyr Lys Val Asp 
         915                920                925
Asn Leu Glu Glu Phe Leu Asn Asp Pro Leu Lys Lys His Thr Leu Ile 
     930                935                940
Arg Phe Leu Pro Arg Pro Ile Arg Gln Gln Leu Leu Tyr Lys Arg Arg 
 945                950                955                960
Tyr Ile Phe Ser Val Val Glu Asn Leu Gln Arg Leu Cys Tyr Met Gly 
                 965                970                975
Val Leu Gln Phe Gly Pro Thr Glu Lys Phe Gln Asp Lys Asp Gln Val 
             980                985                990
Phe Ile Phe Leu Lys Lys Asn Ala Val Ile Val Asp Thr Thr Ile Cys 
         995                1000                1005
Asp Pro His Tyr Asn Leu Gly Arg Arg Arg Arg Pro Phe Glu Arg Arg 
     1010                1015                1020
Leu Tyr Val Leu Asn Ser Met Gln Asp Val Glu Asn Tyr Trp Phe Asp 
 1025                1030                1035                1040
Leu Gln Cys Val Cys Leu Asn Thr Pro Leu Gly Val Val Arg Cys Pro 
                 1045                1050                1055
Arg Val Arg Lys Asn Ser Ser Thr Asp Gln Gly Ser Asp Glu Glu Gly 
             1060                1065                1070
Ser Leu Gln Lys Glu Gln Glu Ser Ala Met Asp Lys His Asn Leu Glu 
         1075                1080                1085
Arg Lys Cys Ala Met Leu Glu Tyr Thr Thr Gly Ser Arg Glu Val Val 
     1090                1095                1100
Asp Glu Gly Leu Ile Pro Gly Asp Gly Leu Gly Ala Ala Gly Leu Asp 
 1105                1110                1115                1120
Ser Ser Phe Tyr Gly His Leu Lys Arg Asn Trp Ile Trp Thr Ser Tyr 
                 1125                1130                1135
Ile Ile Asn Gln Ala Lys Lys Glu Asn Thr Ala Ala Glu Asn Gly Leu 
             1140                1145                1150
Thr Val Arg Leu Gln Thr Phe Leu Ser Lys Arg Pro Met Pro Leu Ser 
         1155                1160                1165
Ala Arg Gly Asn Ser Arg Leu Asn Ile Trp Gly Glu Ala Arg Val Gly 
     1170                1175                1180
Ser Glu Leu Cys Ala Gly Trp Glu Glu Gln Phe Glu Val Asp Arg Glu 
 1185                1190                1195                1200
Pro Ser Leu Asp Arg Asn Arg Arg Val Arg Gly Gly Lys Ser Gln Lys 
                 1205                1210                1215
Arg Lys Arg Leu Lys Lys Asp Pro Gly Lys Lys Ile Lys Arg Lys Lys 
             1220                1225                1230
Lys Gly Glu Phe Pro Gly Glu Lys Ser Lys Arg Leu Arg Tyr His Asp 
         1235                1240                1245
Glu Ala Asp Gln Ser Ala Leu His Arg Met Thr Arg Leu Arg Val Thr 
     1250                1255                1260
Trp Ser Met Gln Glu Asp Gly Leu Leu Val Leu Cys Arg Ile Ala Ser 
 1265                1270                1275                1280
Asn Val Leu Asn Thr Lys Val Lys Gly Pro Phe Val Thr Trp Gln Val 
                 1285                1290                1295
Val Arg Asp Ile Leu His Ala Thr Phe Glu Glu Ser Leu Asp Lys Thr 
             1300                1305                1310
Ser His Ser Leu Gly Arg Arg Ala Arg Tyr Ile Val Lys Asn Pro Gln 
         1315                1320                1325
Ala Tyr Leu Asn Tyr Lys Val Cys Leu Ala Glu Val Tyr Gln Asp Lys 
     1330                1335                1340
Ala Leu Val Gly Asp Phe Met Asn Arg Arg Gly Asp Tyr Asp Asp Pro 
 1345                1350                1355                1360
Lys Val Cys Ala Asn Glu Phe Lys Glu Phe Val Glu Lys Leu Lys Glu 
                 1365                1370                1375
Lys Phe Ser Ser Ala Leu Arg Asn Ser Asn Leu Glu Ile Pro Asp Thr 
             1380                1385                1390
Leu Gln Glu Leu Phe Ala Arg Tyr Arg Val Leu Ala Ile Gly Asp Glu 
         1395                1400                1405
Lys Asp Gln Thr Arg Lys Glu Asp Glu Leu Asn Ser Val Asp Asp Ile 
     1410                1415                1420
His Phe Leu Val Leu Gln Asn Leu Ile Gln Ser Thr Leu Ala Leu Ser 
 1425                1430                1435                1440
Asp Ser Gln Met Lys Ser Tyr Gln Ser Phe Gln Thr Phe Arg Leu Tyr 
                 1445                1450                1455
Arg Glu Tyr Lys Asp His Val Leu Val Lys Ala Phe Met Glu Cys Gln 
             1460                1465                1470
Lys Arg Ser Leu Val Asn Arg Arg Arg Val Asn His Thr Leu Gly Pro 
         1475                1480                1485
Lys Lys Asn Arg Ala Leu Pro Phe Val Pro Met Ser Tyr Gln Leu Ser 
     1490                1495                1500
Gln Thr Tyr Tyr Arg Ile Phe Thr Trp Arg Phe Pro Ser Thr Ile Cys 
 1505                1510                1515                1520
Thr Glu Ser Phe Gln Phe Leu Asp Arg Met Arg Ala Ala Gly Lys Leu 
                 1525                1530                1535
Asp Gln Pro Asp Arg Phe Ser Phe Lys Asp Gln Asp Asn Asn Glu Pro 
             1540                1545                1550
Thr Asn Asp Met Val Ala Phe Ser Leu Asp Gly Pro Gly Gly Asn Cys 
         1555                1560                1565
Val Ala Val Leu Thr Leu Phe Ser Leu Gly Leu Ile Ser Val Asp Val 
     1570                1575                1580
Arg Ile Pro Glu Gln Ile Ile Val Val Asp Ser Ser Met Val Glu Asn 
 1585                1590                1595                1600
Glu Val Ile Lys Ser Leu Gly Lys Asp Gly Ser Leu Glu Asp Asp Glu 
                 1605                1610                1615
Asp Glu Glu Asp Asp Leu Asp Glu Gly Val Gly Gly Lys Arg Arg Ser 
             1620                1625                1630
Met Glu Val Lys Pro Ala Gln Ala Ser His Thr Asn Tyr Leu Leu Met 
         1635                1640                1645
Arg Gly Tyr Tyr Ser Pro Gly Ile Val Ser Thr Arg Asn Leu Asn Pro 
     1650                1655                1660
Asn Asp Ser Ile Val Val Asn Ser Cys Gln Met Lys Phe Gln Leu Arg 
 1665                1670                1675                1680
Cys Thr Pro Val Pro Ala Arg Leu Arg Pro Ala Ala Ala Pro Leu Glu 
                 1685                1690                1695
Glu Leu Thr Met Gly Thr Ser Cys Leu Pro Asp Thr Phe Thr Lys Leu 
             1700                1705                1710
Ile Asn Pro Gln Glu Asn Thr Cys Ser Leu Glu Glu Phe Val Leu Gln 
         1715                1720                1725
Leu Glu Leu Ser Gly Tyr Ser Pro Glu Asp Leu Thr Ala Ala Leu Glu 
     1730                1735                1740
Ile Leu Glu Ala Ile Ile Ala Thr Gly Cys Phe Gly Ile Asp Lys Glu 
 1745                1750                1755                1760
Glu Leu Arg Arg Arg Phe Ser Ala Leu Glu Lys Ala Gly Gly Gly Arg 
                 1765                1770                1775
Thr Arg Thr Phe Ala Asp Cys Ile Gln Ala Leu Leu Glu Gln His Gln 
             1780                1785                1790
Val Leu Glu Val Gly Gly Asn Thr Ala Arg Leu Val Ala Met Gly Ser 
         1795                1800                1805
Ala Trp Pro Trp Leu Leu His Ser Val Arg Leu Lys Asp Arg Glu Asp 
     1810                1815                1820
Ala Asp Ile Gln Arg Glu Asp Pro Gln Ala Arg Pro Leu Glu Gly Ser 
 1825                1830                1835                1840
Ser Ser Glu Asp Ser Pro Pro Glu Gly Gln Ala Pro Pro Ser His Ser 
                 1845                1850                1855
Pro Arg Gly Thr Lys Arg Arg Ala Ser Trp Ala Ser Glu Asn Gly Glu 
             1860                1865                1870
Thr Asp Ala Glu Gly Thr Gln Met Thr Pro Ala Lys Arg Pro Ala Leu 
         1875                1880                1885
Gln Asp Ser Asn Leu Ala Pro Ser Leu Gly Pro Gly Ala Glu Asp Gly 
     1890                1895                1900
Ala Glu Ala Gln Ala Pro Ser Pro Pro Pro Ala Leu Glu Asp Thr Ala 
 1905                1910                1915                1920
Ala Ala Gly Ala Ala Gln Glu Asp Gln Glu Gly Val Gly Glu Phe Ser 
                 1925                1930                1935
Ser Pro Gly Gln Glu Gln Leu Ser Gly Gln Ala Gln Pro Pro Glu Gly 
             1940                1945                1950
Ser Glu Asp Pro Arg Gly Phe Thr Glu Ser Phe Gly Ala Ala Asn Ile 
         1955                1960                1965
Ser Gln Ala Ala Arg Glu Arg Asp Cys Glu Ser Val Cys Phe Ile Gly 
     1970                1975                1980
Arg Pro Trp Arg Val Val Asp Gly His Leu Asn Leu Pro Val Cys Lys 
 1985                1990                1995                2000
Gly Met Met Glu Ala Met Leu Tyr His Ile Met Thr Arg Pro Gly Ile 
                 2005                2010                2015
Pro Glu Ser Ser Leu Leu Arg His Tyr Gln Gly Val Leu Gln Pro Val 
             2020                2025                2030
Ala Val Leu Glu Leu Leu Gln Gly Leu Glu Ser Leu Gly Cys Ile Arg 
         2035                2040                2045
Lys Arg Trp Leu Arg Lys Pro Arg Pro Val Ser Leu Phe Ser Thr Pro 
     2050                2055                2060
Val Val Glu Glu Val Glu Val Pro Ser Ser Leu Asp Glu Ser Pro Met 
 2065                2070                2075                2080
Ala Phe Tyr Glu Pro Thr Leu Asp Cys Thr Leu Arg Leu Gly Arg Val 
                 2085                2090                2095
Phe Pro His Glu Val Asn Trp Asn Lys Trp Ile His Leu Ter 
             2100                2105                2110



<210> 3149
<211> 6878
<212> DNA
<213> Rattus norvegicus
<308> L28801
<400> 3149

gccggggct  ctaactgaa  aggccatgg  cgcgctcga  tcgttgttg  acgaggtgg  60
cctggaggg  ctcgacggc  tgtgcctgc  cgcgctgtg  agccgcctg  aatcccgct  120
gcctgcctt  cctttgccg  tggaaccct  cacgcagga  tttctgtgg  gggccttag  180
cacgcaccc  ggcatcagt  tctacgagg  gccgcgaga  cgacctgac  tgcagctcc  240
agaccgata  gaagaaatc  acttggaaa  tggaatttt  gagtccagg  gggacccag  300
cactctgga  gatgtctac  ccattcata  gatcttaga  aataaggat  gcatccagg  360
ctcctgccg  tactttaag  agagaaagg  catcaccag  agcatcagg  gcaagtgtt  420
gcagcctcg  tgtacaatg  tagaagcct  cagcaggtg  ggtaagaag  tcatcattg  480
ggcttccca  gacatgcga  accgggcct  gataggcct  gagggggat  ctgatctga  540
gcttcctga  ttctcctac  gcattttgg  gcggttagg  cgatcgaga  ggcaagggg  600
gctgcaacg  gaccttcac  ccaccgctt  caaggtcga  gctgggaag  ttcattatc  660
caggaaaat  ttgaacaag  atgggctca  tacaatgca  tcacacgtg  tccgactgc  720
tactggagc  cagcaacac  ccatcctcc  cctccttaa  cggtttcat  tagacagga  780
gagcaagta  gacatcctc  tggagaagc  gtctatgat  ctgagcaca  ggagcaacc  840
gatcgagac  ctgggcaag  tgagggagg  gctgggact  tgtgaaagg  cgttcaagc  900
tctgtacca  tacatgctg  atgctgggc  ggccaaagt  gtgtccctt  ccttgcagg  960
gattcaccc  gagtgtggt  cctgtaaga  caagaaagg  actgatgtc  tggttcggt  1020
ccttaagct  ctgaaggag  tcaggcgaa  gatggaaga  gaccatgac  acgatgacg  1080
tgaagaggc  atctccaag  ctgtacctc  cgtggacat  gtgtttgag  gggacatgc  1140
cacgcagac  tacgagctc  ttgagcgca  aggaacgaa  ggaatttcc  aagctgaga  1200
ccgagttgc  atgaatgtg  gaaaactgg  agcaagaat  ctgtgtcgg  tccttcaga  1260
gttcaaggt  gtcaaggga  tcatggaag  tgaaggccg  cagaggacc  ccaagtaca  1320
ttcctgtgt  tttgcggag  agagtgact  gagccgcca  tatgcgcgt  aaaaggccc  1380
aggagagct  ctaaccact  tgagcctcg  ctcagtgca  gatgaatcc  tcatgcctg  1440
gggtgaaga  gccttcctc  ctgactccg  aagtgagga  gagagcagc  gcagtggca  1500
gcgtagggg  cgagggtcc  gggggcatt  aagagcctc  ggggatgct  ggcctggct  1560
tcggcctca  cactccact  cagccaagg  cgggtggaa  gtcctaaat  tgcacccat  1620
aaagaagcc  aaaagtgcc  ctgtggaaa  atcccgccg  agctctgct  gtagggatg  1680
cctggacac  agcagctca  ccgagctca  tataccctt  gaccctcac  gcatggaca  1740
tcacagtgg  gacatcgct  tgattgagg  ggtccggct  gataacccc  aggagggtg  1800
tggctccca  aagggcgga  ggcatggct  aggccagga  aagcctcac  aaacatacc  1860
actgctaaa  cgcagaaat  tgattatag  agctgtcac  aacctccgc  tgattgaga  1920
cctgttcac  attcagaag  tgatcatgg  ccaggagaa  caagagggt  tctccacca  1980
atgctgtaa  aagtccatt  tccgcttgg  gcggaacct  tctgaggag  gtctcttga  2040
attgtatag  actacagtc  ttcaagatg  catcaagaa  aaggtagac  tggtcgtgc  2100
cccttccat  gaccagaat  accctcttg  gagaagtgc  attgagcag  ttcgcttcc  2160
gatctccaa  tcaagcaca  caaacaggg  taaagttcc  ccggcccca  caccccaag  2220
ggaagcaga  gagggaaac  aagaaccag  ggtcccaag  agatcagca  actctgaag  2280
gaacacatc  tcgaagcca  aaagcacac  ggtgaaaaa  acagatgag  aaatgggca  2340
aaccccact  aagaattac  aacctgtca  agttcctgg  cttgggcgc  ccatagggt  2400
ccttcccaa  atgccacgc  ttcgggtga  gcacctgtt  ctgtggtac  tggtgtatg  2460
gcatcctgc  agccacact  gggaacagc  tactttcca  agtgagagg  aaacaggca  2520
gcaggagcc  agcagacca  gggtccagc  ctcctcagg  gatgactgg  actcctctg  2580
agccaaaaa  agcacagaa  gcagctcct  ggaggcaga  atggaactc  ccacagaga  2640
agtgtatgt  gatgagatc  catggatgc  ctacgtccc  cccatcccc  tccacagag  2700
cttcggctt  ggctgggct  ttgtcagtg  cattcttct  tgccttccc  tctccatct  2760
tgtccaagt  gttcaagtc  gctacaagg  ggataacct  gaggatttt  tgaatgacc  2820
tctgaagaa  cacacactg  tccgcttcc  ccctaggca  atccggcag  agctactgt  2880
taagaggcg  tatattttc  cggtggtgg  gaacctgca  cggctgtgc  acatggggc  2940
gctacagtt  ggacccaca  agaagtttc  ggataaaga  caggtcttt  ttttcctga  3000
gaagaatgc  gtcattgtg  acaccacca  ctgtgaccc  cattacaac  tggcccaca  3060
cagccggcc  tttgagaga  gtctctacg  cttggattc  atgcaggat  tggaaagct  3120
ctggtttga  ctgcagtgt  tctgcctaa  caccccact  ggtgtggtg  gttgtccat  3180
tgcacagaa  atctgccct  atccgggca  tgacccaga  ggcagcttg  ggaaggagc  3240
agagagcgc  atggacaag  acaacctag  gcgcaagtg  gccatgctg  agtatacca  3300
ggggagccg  gaagttgtg  atgaaggct  agtccctgg  gatggactg  gagctgctg  3360
gctggactc  agcttctat  cacacctga  gcgcaactg  gtctggacc  gctatatca  3420
caacaaagc  agaaagaac  acacctccg  aaatgggct  acaggaaga  tccagactt  3480
cctgtctaa  cgcccaatg  cacttgggt  tggaggcag  ggccgtctg  ctctctggt  3540
agaggggaa  gctgatgct  agctctgtg  tgacaaaga  gaacacttt  aactggacc  3600
agaacctac  cctggcagg  accgaaaag  gcgtggggg  aagagtcag  agcggaagc  3660
gctgaagaa  gagcccatc  ggaagacca  gcgaaggag  agaggagag  atccagaag  3720
caaaagcaa  aaactacgc  accaagatg  ggctgacca  aacgccctc  ggatgatga  3780
ccggcttcg  gtttcttgg  ccatgcagg  ggatgggtt  ctaatgctc  gccgaattg  3840
cagcaatgt  ctcaacacc  aggtgaaag  accatttgt  acctggcag  tcgtgcgtg  3900
cattttgca  gctaccttt  aagagtctt  ggataaaac  tctcactcg  ttggacgaa  3960
agctcgcta  atagtcaaa  atccccagg  ctttatgaa  tacaaagtc  gcctggcag  4020
agtgtacca  gataaggca  tcgttggag  tttcatgag  cggaaggat  actacgaag  4080
cccaaaggt  tgtgccaag  agtttaaag  atttgtgga  aagctgaaa  agaagttca  4140
ctctggcct  aggaacccc  accttgaga  cccagacac  ctgcaggaa  tctttgcca  4200
ataccgggt  ttggcaatc  gagatgaaa  ggaccgtgt  aggaaggag  atgaactga  4260
tagtgtgga  gacatccac  tcctggtgc  acagaacct  atccagagc  cactgtccc  4320
ctctaacag  cagtccaac  cttgccagt  cttccagat  ttccgcctc  accgggagt  4380
ccgggagcc  gtgctggtg  gggccttca  ggagtgcca  aagaggagc  tggtcaacc  4440
acgccgtgt  agccactcc  agggtccca  gaagaaccg  gctgtgccc  ttgtgccca  4500
gtcctacca  ctctcccag  catactaca  gcttttcac  tggcgattt  ccaccaccg  4560
ctgcaccga  tccttccag  tctatgaca  actacgggc  aacggcata  tagaccagc  4620
tgatcattt  tctttcaag  acatggata  caatgaccc  tcaagtgac  tggtggcgt  4680
ttctttgga  agccctgga  gacactgtg  gacagccct  gccctcttc  ccttgggcc  4740
cctctctgt  gatgtccga  tcccagagc  gattgtggt  gtagacagc  ccatggtgg  4800
gagtgaggt  atgaagagc  tggggaaag  tggcggctt  gatgatgat  atgaggagg  4860
agacctgga  gaaggttca  ggaccaagc  tcagagtgt  gaagtaaag  cccatcagg  4920
ctcacacac  aagtacctg  tgatgagag  ttactacac  gtgcctggc  tggtcagca  4980
gcgcaacct  aaccccaat  acagcattg  ggtcaattc  tgccaggtt  aattccgac  5040
gcgcaatac  cctgcaccc  cccatcttg  gcccactgg  cccacagcc  caccgctag  5100
agagctcca  gctggccct  cctgcctcc  tgcctcctt  accagcctg  tggatccac  5160
gctgcacac  cgctgccca  aagagtttg  ccaccagat  gcacagtct  ggtacagcc  5220
tgaggacgt  gctgcgtcc  tagagatcc  gcaggctgt  gcagctgct  actgcttcg  5280
ggttgacag  gagaagctg  gcagacagt  ctctgcctt  gagaagata  cggacaagc  5340
caccaggac  ttcctggac  atatccagg  cctcttgga  cagcaacaa  tcatggaag  5400
tggaggcaa  actgtgcgc  tagtggcca  ggcctctgc  cagccctgg  tcctgcctt  5460
agtgcgtct  aaagatgtg  aaatagaca  caaggcctc  ggggatgac  gccaatcta  5520
actccctgc  gggtcttcc  tcgaagacc  cacctctga  ggtgcacca  ttcctccag  5580
cagctccaa  ggcactaaa  agcgcccct  ctgctctat  cagagccct  aaactgatg  5640
tgaggaagc  acaaggctc  ctgccaaga  gcccacatt  caagatgtc  gtgtggctg  5700
cagtcctag  cctggaaca  aagagcaga  agaggccca  gctcagttt  cagctcctg  5760
agatgcagg  gcagagggc  ccaggcagg  gagccaaga  agtgttggt  tctcaggcc  5820
agagcagct  ggctgtgag  tccagcttc  agaaaattc  gaagacccc  gaggactta  5880
agagagcaa  atggcccag  tagcatggg  gagcggctg  gaaagagta  gttttgtcg  5940
tcgcccatg  cgtggtgtg  acgggcgcc  gaacatgcc  gtgtgcaaa  gcatgatgg  6000
agccgtgct  taccacatc  tgtcaaggc  cggtgttcc  gagagctgc  tgctacagt  6060
ctaccaggg  gtcctacag  ctgttgctg  gcttgagct  ctccggggc  tagagtctc  6120
cggctgtat  cagaagcgg  tgctgaaga  gccagcgag  gtctcactc  tctccaggc  6180
tgtggtgga  ggcctaggt  aggccagtg  ggccgaggc  ctctcctgt  aggggagca  6240
tgtcacctt  tatgaacct  ctctggact  taccatccg  ctgggccgt  tcttccccc  6300
tgacatcaa  tggaaacaa  gtggatcca  ttatagatg  gtcccaggc  agcagagga  6360
cctctgccc  tgcttaatt  ttccgcctg  actgtccca  gagccccgt  cttcacaca  6420
ctgttacca  agctcggcc  agcctagca  aggtgtagc  actagcagg  gacttcagt  6480
ccctctgct  tcggctgct  ttggtccca  gtgcccagc  ttcctgcag  cctgtgtcc  6540
gccctggac  caggctcta  catcagcag  atctgcaag  gatgttgtt  agggagcag  6600
ctgatgacc  agccctgag  cacctcaca  gcaccacac  attcagact  agaggaaga  6660
acatcacag  tgtacctgg  agagtctgc  cctcttaag  tagggcatc  caacttggc  6720
tgaactgag  tcaggtctc  agctcccaa  ggcccctcc  gccagaagc  aggcctgta  6780
gttttgctt  tgtttttgt  ttattttgc  ctcttttca  tagatacaa  cccctggca  6840
gtatttatt  attttttaa  taaagtaag  tgaaatgc  6878



<210> 3150
<211> 2149
<212> PRT
<213> Rattus norvegicus
<308> L28801
<400> 3150

Met Asp Ala Leu Glu Ser Leu Leu Asp Glu Val Ala Leu Glu Gly Leu 
  1               5                  10                  15
Asp Gly Leu Cys Leu Pro Ala Leu Trp Ser Arg Leu Glu Ser Arg Ser 
             20                  25                  30
Pro Ala Phe Pro Leu Pro Leu Glu Pro Tyr Thr Gln Glu Phe Leu Trp 
         35                  40                  45
Arg Ala Leu Val Thr His Pro Gly Ile Ser Phe Tyr Glu Glu Pro Arg 
     50                  55                  60
Glu Arg Pro Asp Leu Gln Leu Gln Asp Arg Tyr Glu Glu Ile Asp Leu 
 65                  70                  75                  80
Glu Thr Gly Ile Leu Glu Ser Arg Arg Asp Pro Val Thr Leu Glu Asp 
                 85                  90                  95
Val Tyr Pro Ile His Met Ile Leu Glu Asn Lys Asp Gly Ile Gln Gly 
             100                105                110
Ser Cys Arg Tyr Phe Lys Glu Arg Lys Asp Ile Thr Ser Ser Ile Arg 
         115                120                125
Ser Lys Cys Leu Gln Pro Arg Cys Thr Met Val Glu Ala Phe Ser Arg 
     130                135                140
Trp Gly Lys Lys Leu Ile Ile Val Ala Ser Gln Asp Met Arg Tyr Arg 
 145                150                155                160
Ala Leu Ile Gly Leu Glu Gly Asp Pro Asp Leu Lys Leu Pro Asp Phe 
                 165                170                175
Ser Tyr Cys Ile Leu Glu Arg Leu Gly Arg Ser Arg Trp Gln Gly Glu 
             180                185                190
Leu Gln Arg Asp Leu His Thr Thr Ala Phe Lys Val Asp Ala Gly Lys 
         195                200                205
Leu His Tyr His Arg Lys Ile Leu Asn Lys Asn Gly Leu Ile Thr Met 
     210                215                220
Gln Ser His Val Ile Arg Leu Pro Thr Gly Ala Gln Gln His Ser Ile 
 225                230                235                240
Leu Leu Leu Leu Asn Arg Phe His Val Asp Arg Arg Ser Lys Tyr Asp 
                 245                250                255
Ile Leu Met Glu Lys Leu Ser Met Met Leu Ser Thr Arg Ser Asn Gln 
             260                265                270
Ile Glu Thr Leu Gly Lys Leu Arg Glu Glu Leu Gly Leu Cys Glu Arg 
         275                280                285
Thr Phe Lys Arg Leu Tyr Gln Tyr Met Leu Asn Ala Gly Leu Ala Lys 
     290                295                300
Val Val Ser Leu Pro Leu Gln Glu Ile His Pro Glu Cys Gly Pro Cys 
 305                310                315                320
Lys Thr Lys Lys Gly Thr Asp Val Met Val Arg Cys Leu Lys Leu Leu 
                 325                330                335
Lys Glu Phe Arg Arg Lys Met Glu Asp Asp His Asp Asp Asp Asp Asp 
             340                345                350
Glu Glu Ala Ile Ser Lys Ala Val Pro Pro Val Asp Ile Val Phe Glu 
         355                360                365
Arg Asp Met Leu Thr Gln Thr Tyr Glu Leu Ile Glu Arg Arg Gly Thr 
     370                375                380
Lys Gly Ile Ser Gln Ala Glu Ile Arg Val Ala Met Asn Val Gly Lys 
 385                390                395                400
Leu Glu Ala Arg Met Leu Cys Arg Leu Leu Gln Arg Phe Lys Val Val 
                 405                410                415
Lys Gly Phe Met Glu Asp Glu Gly Arg Gln Arg Thr Thr Lys Tyr Ile 
             420                425                430
Ser Cys Val Phe Ala Glu Glu Ser Asp Leu Ser Arg Gln Tyr Ala Arg 
         435                440                445
Glu Lys Ala Arg Gly Glu Leu Leu Thr Thr Val Ser Leu Ala Ser Val 
     450                455                460
Gln Asp Glu Ser Leu Met Pro Glu Gly Glu Glu Ala Phe Leu Ser Asp 
 465                470                475                480
Ser Glu Ser Glu Glu Glu Ser Ser Cys Ser Gly Lys Arg Arg Gly Arg 
                 485                490                495
Gly Ser Arg Gly His Ser Arg Ala Ser Gly Asp Ala Gly Pro Gly Ser 
             500                505                510
Arg Pro His His Ser Thr Pro Ala Lys Gly Gly Trp Lys Val Leu Asn 
         515                520                525
Leu His Pro Leu Lys Lys Pro Lys Ser Ala Ala Val Glu Arg Ser Arg 
     530                535                540
Arg Ser Ser Ala Cys Arg Asp Gly Leu Asp Thr Ser Ser Ser Ser Glu 
 545                550                555                560
Leu Asn Ile Pro Phe Asp Pro His Ser Met Asp Ser His Ser Gly Asp 
                 565                570                575
Ile Ala Val Ile Glu Glu Val Arg Leu Asp Asn Pro Lys Glu Gly Gly 
             580                585                590
Gly Ser Gln Lys Gly Gly Arg His Gly Ser Gly Gln Asp Lys Pro His 
         595                600                605
Lys Thr Tyr Arg Leu Leu Lys Arg Arg Asn Leu Ile Ile Glu Ala Val 
     610                615                620
Thr Asn Leu Arg Leu Ile Glu Ser Leu Phe Thr Ile Gln Lys Met Ile 
 625                630                635                640
Met Asp Gln Glu Lys Gln Glu Gly Val Ser Thr Lys Cys Cys Lys Lys 
                 645                650                655
Ser Ile Ile Arg Leu Val Arg Asn Leu Ser Glu Glu Gly Leu Leu Arg 
             660                665                670
Leu Tyr Arg Thr Thr Val Ile Gln Asp Gly Ile Lys Lys Lys Val Asp 
         675                680                685
Leu Val Val His Pro Ser Met Asp Gln Asn Asp Pro Leu Val Arg Ser 
     690                695                700
Ala Ile Glu Gln Val Arg Phe Arg Ile Ser Asn Ser Ser Thr Ala Asn 
 705                710                715                720
Arg Val Lys Val Pro Pro Ala Pro Ala Pro Gln Glu Glu Ala Glu Glu 
                 725                730                735
Gly Asn Gln Glu Pro Glu Val Pro Ser Arg Ser Ala Asp Ser Glu Ala 
             740                745                750
Asn Thr Ser Ser Lys Pro Glu Ser Thr Arg Val Lys Lys Thr Asp Glu 
         755                760                765
Lys Met Gly Ile Thr Pro Leu Lys Asn Tyr Lys Pro Val Ile Val Pro 
     770                775                780
Gly Leu Gly Arg Ser Ile Gly Phe Leu Pro Lys Met Pro Arg Leu Arg 
 785                790                795                800
Val Met His Leu Phe Leu Trp Tyr Leu Val Tyr Gly His Pro Ala Ser 
                 805                810                815
His Thr Gly Glu Gln Pro Thr Phe His Ser Glu Arg Lys Thr Gly Lys 
             820                825                830
Gln Glu Pro Ser Arg Pro Gly Val Gln Pro Ser Ser Gly Asp Asp Trp 
         835                840                845
Asp Ser Ser Glu Ala Lys Asn Ser Thr Glu Ser Ser Ser Trp Glu Ala 
     850                855                860
Glu Met Glu Leu Ser Thr Glu Arg Val Tyr Val Asp Glu Ile Ser Trp 
 865                870                875                880
Met Arg Tyr Val Pro Pro Ile Pro Ile His Arg Asp Phe Gly Phe Gly 
                 885                890                895
Trp Ala Leu Val Ser Asp Ile Leu Leu Cys Leu Pro Leu Ser Ile Phe 
             900                905                910
Val Gln Val Val Gln Val Ser Tyr Lys Val Asp Asn Leu Glu Asp Phe 
         915                920                925
Leu Asn Asp Pro Leu Lys Lys His Thr Leu Ile Arg Phe Leu Pro Arg 
     930                935                940
His Ile Arg Gln Gln Leu Leu Tyr Lys Arg Arg Tyr Ile Phe Ser Val 
 945                950                955                960
Val Glu Asn Leu Gln Arg Leu Cys Tyr Met Gly Leu Leu Gln Phe Gly 
                 965                970                975
Pro Thr Glu Lys Phe Gln Asp Lys Asp Gln Val Phe Val Phe Leu Lys 
             980                985                990
Lys Asn Ala Val Ile Val Asp Thr Thr Ile Cys Asp Pro His Tyr Asn 
         995                1000                1005
Leu Ala His Ser Ser Arg Pro Phe Glu Arg Arg Leu Tyr Val Leu Asp 
     1010                1015                1020
Ser Met Gln Asp Val Glu Ser Tyr Trp Phe Asp Leu Gln Cys Ile Cys 
 1025                1030                1035                1040
Leu Asn Thr Pro Leu Gly Val Val Arg Cys Pro Cys Ala Gln Lys Ile 
                 1045                1050                1055
Cys Pro Asp Pro Gly Ser Asp Pro Glu Gly Ser Leu Arg Lys Glu Gln 
             1060                1065                1070
Glu Ser Ala Met Asp Lys His Asn Leu Glu Arg Lys Cys Ala Met Leu 
         1075                1080                1085
Glu Tyr Thr Thr Gly Ser Arg Glu Val Val Asp Glu Gly Leu Val Pro 
     1090                1095                1100
Gly Asp Gly Leu Gly Ala Ala Gly Leu Asp Ser Ser Phe Tyr Ala His 
 1105                1110                1115                1120
Leu Lys Arg Asn Trp Val Trp Thr Ser Tyr Ile Ile Asn Lys Ala Arg 
                 1125                1130                1135
Lys Asn Asn Thr Ser Glu Asn Gly Leu Thr Gly Arg Leu Gln Thr Phe 
             1140                1145                1150
Leu Ser Lys Arg Pro Met Pro Leu Gly Ser Gly Gly Ser Gly Arg Leu 
         1155                1160                1165
Pro Leu Trp Ser Glu Gly Lys Ala Asp Ala Glu Leu Cys Ala Asp Lys 
     1170                1175                1180
Glu Glu His Phe Glu Leu Asp Arg Glu Pro Thr Pro Gly Arg Asn Arg 
 1185                1190                1195                1200
Lys Val Arg Gly Gly Lys Ser Gln Lys Arg Lys Arg Leu Lys Lys Glu 
                 1205                1210                1215
Pro Ile Arg Lys Thr Lys Arg Arg Arg Arg Gly Glu His Pro Glu Ala 
             1220                1225                1230
Lys Ser Lys Lys Leu Arg Tyr Gln Asp Glu Ala Asp Gln Asn Ala Leu 
         1235                1240                1245
Arg Met Met Thr Arg Leu Arg Val Ser Trp Ser Met Gln Glu Asp Gly 
     1250                1255                1260
Leu Leu Met Leu Cys Arg Ile Ala Ser Asn Val Leu Asn Thr Lys Val 
 1265                1270                1275                1280
Lys Gly Pro Phe Val Thr Trp Gln Val Val Arg Asp Ile Leu His Ala 
                 1285                1290                1295
Thr Phe Glu Glu Ser Leu Asp Lys Thr Ser His Ser Val Gly Arg Arg 
             1300                1305                1310
Ala Arg Tyr Ile Val Lys Asn Pro Gln Ala Phe Met Asn Tyr Lys Val 
         1315                1320                1325
Cys Leu Ala Glu Val Tyr Gln Asp Lys Ala Leu Val Gly Asp Phe Met 
     1330                1335                1340
Ser Arg Lys Asp Asn Tyr Glu Asp Pro Lys Val Cys Ala Lys Glu Phe 
 1345                1350                1355                1360
Lys Glu Phe Val Glu Lys Leu Lys Glu Lys Phe Ser Ser Gly Leu Arg 
                 1365                1370                1375
Asn Pro Asn Leu Glu Ile Pro Asp Thr Leu Gln Glu Leu Phe Ala Lys 
             1380                1385                1390
Tyr Arg Val Leu Ala Ile Gly Asp Glu Lys Asp Arg Val Arg Lys Glu 
         1395                1400                1405
Asp Glu Leu Asn Ser Val Glu Asp Ile His Phe Leu Val Leu Gln Asn 
     1410                1415                1420
Leu Ile Gln Ser Thr Leu Ser Leu Ser Asn Ser Gln Ser Asn Ser Cys 
 1425                1430                1435                1440
Gln Ser Phe Gln Ile Phe Arg Leu Tyr Arg Glu Phe Arg Glu Pro Val 
                 1445                1450                1455
Leu Val Arg Ala Phe Met Glu Cys Gln Lys Arg Ser Leu Val Asn Arg 
             1460                1465                1470
Arg Arg Val Ser His Ser Gln Gly Pro Lys Lys Asn Arg Ala Val Pro 
         1475                1480                1485
Phe Val Pro Met Ser Tyr Gln Leu Ser Gln Ser Tyr Tyr Lys Leu Phe 
     1490                1495                1500
Thr Trp Arg Phe Pro Thr Thr Val Cys Thr Glu Ser Phe Gln Phe Tyr 
 1505                1510                1515                1520
Asp Arg Leu Arg Ala Asn Gly Ile Leu Asp Gln Pro Asp His Phe Ser 
                 1525                1530                1535
Phe Lys Asp Met Asp Ser Asn Asp Pro Ser Ser Asp Leu Val Ala Phe 
             1540                1545                1550
Ser Leu Asp Ser Pro Gly Gly His Cys Val Thr Ala Leu Ala Leu Phe 
         1555                1560                1565
Ser Leu Gly Leu Leu Ser Val Asp Val Arg Ile Pro Glu Gln Ile Val 
     1570                1575                1580
Val Val Asp Ser Ser Met Val Glu Ser Glu Val Met Lys Ser Leu Gly 
 1585                1590                1595                1600
Lys Asp Gly Gly Leu Asp Asp Asp Asp Glu Glu Glu Asp Leu Asp Glu 
                 1605                1610                1615
Gly Ser Gly Thr Lys Arg Gln Ser Val Glu Val Lys Ala His Gln Ala 
             1620                1625                1630
Ser His Thr Lys Tyr Leu Leu Met Arg Gly Tyr Tyr Thr Val Pro Gly 
         1635                1640                1645
Met Val Ser Thr Arg Asn Leu Asn Pro Asn Asp Ser Ile Val Val Asn 
     1650                1655                1660
Ser Cys Gln Val Lys Phe Arg Leu Arg Asn Thr Pro Ala Pro Thr His 
 1665                1670                1675                1680
Leu Gly Pro Thr Gly Pro Thr Ala Thr Pro Leu Glu Glu Leu Gln Ala 
                 1685                1690                1695
Gly Pro Ser Cys Leu Pro Ala Ser Phe Thr Ser Leu Val Asp Pro Gln 
             1700                1705                1710
Leu His Thr Arg Cys Pro Glu Glu Phe Ala His Gln Met Ala Gln Ser 
         1715                1720                1725
Gly Tyr Ser Pro Glu Asp Val Ala Ala Ser Leu Glu Ile Leu Gln Ala 
     1730                1735                1740
Val Ala Ala Ala Asp Cys Phe Gly Val Asp Arg Glu Lys Leu Ser Arg 
 1745                1750                1755                1760
Gln Phe Ser Ala Leu Glu Lys Ile Ala Asp Lys Arg Thr Arg Thr Phe 
                 1765                1770                1775
Leu Asp Tyr Ile Gln Asp Leu Leu Glu Gln Gln Gln Val Met Glu Val 
             1780                1785                1790
Gly Gly Asn Thr Val Arg Leu Val Ala Met Ala Ser Ala Gln Pro Trp 
         1795                1800                1805
Leu Leu Pro Ser Val Arg Leu Lys Asp Val Glu Ile Asp Thr Lys Ala 
     1810                1815                1820
Ser Gly Asp Asp Ser Gln Ser Arg Leu Pro Ala Gly Ser Ser Ile Glu 
 1825                1830                1835                1840
Asp His Thr Ser Glu Gly Ala Pro Ile Pro Pro Val Ser Ser Asn Gly 
                 1845                1850                1855
Thr Lys Lys Arg Pro Tyr Cys Ser Ile Gln Ser Pro Glu Thr Asp Ala 
             1860                1865                1870
Glu Glu Ala Thr Arg Leu Pro Ala Lys Lys Pro Thr Leu Gln Asp Val 
         1875                1880                1885
Cys Val Ala Ala Ser Pro Arg Pro Gly Thr Glu Glu Gln Thr Glu Ala 
     1890                1895                1900
Gln Ala Gln Phe Ala Ala Pro Glu Asp Ala Gly Ala Glu Gly Pro Arg 
 1905                1910                1915                1920
Gln Glu Ser Gln Glu Ser Val Gly Val Ser Gly Leu Glu Gln Leu Gly 
                 1925                1930                1935
Cys Glu Phe Gln Leu Pro Glu Asn Ser Glu Asp Pro Arg Gly Leu Thr 
             1940                1945                1950
Glu Ser Asn Met Ala Gln Val Ala Trp Glu Ser Gly Cys Glu Arg Val 
         1955                1960                1965
Cys Phe Val Gly Arg Pro Trp Arg Gly Val Asp Gly Arg Leu Asn Met 
     1970                1975                1980
Pro Val Cys Lys Gly Met Met Glu Ala Val Leu Tyr His Ile Met Ser 
 1985                1990                1995                2000
Arg Pro Gly Val Pro Glu Ser Cys Leu Leu Gln Tyr Tyr Gln Gly Val 
                 2005                2010                2015
Leu Gln Pro Val Ala Val Leu Glu Leu Leu Arg Gly Leu Glu Ser Leu 
             2020                2025                2030
Gly Cys Ile Gln Lys Arg Met Leu Lys Lys Pro Ala Ser Val Ser Leu 
         2035                2040                2045
Phe Ser Arg Pro Val Val Glu Gly Leu Gly Gln Ala Ser Glu Ala Glu 
     2050                2055                2060
Ala Leu Ser Cys Gln Gly Ser Thr Val Thr Phe Tyr Glu Pro Thr Leu 
 2065                2070                2075                2080
Asp Cys Thr Ile Arg Leu Gly Arg Val Phe Pro His Asp Ile Asn Trp 
                 2085                2090                2095
Lys Gln Ser Gly Ser Ile Tyr Arg Cys Val Pro Gly Gln Gln Arg Ser 
             2100                2105                2110
Leu Cys Pro Cys Leu Ile Val Pro Pro Gly Leu Ser Gln Glu Pro Arg 
         2115                2120                2125
Pro Ser His Ser Cys Tyr Gln Ser Ser Ala Gln Pro Ser Thr Gly Val 
     2130                2135                2140
Ala Thr Ser Arg Ter 
 2145



<210> 3151
<211> 6996
<212> DNA
<213> Homo sapiens
<308> U02619
<400> 3151

atggaccaa  gcccttggc  gtgcgttgc  cacccccgg  gcgccgcga  tgaagtagc  60
atggacgcg  tggagtcgt  gttggacga  gtcgctctg  aggggctcg  tggcctgtg  120
ctgccagcg  tgtggagcc  gctggagac  cgagtgccg  ccttcccgc  gcctttgga  180
ccctgcacg  aggagtttc  ctggcgggc  ctcgccacg  acccgggca  cagcttcta  240
gaggagcct  gggagcgac  cgacctaca  ctccaggac  ggtatgaag  aattgattt  300
gaaactgga  ttttggagt  taggaggga  ccggtggct  tggaggatg  ctaccccat  360
catatgatc  tagagaata  ggatggcat  cagggctca  gccgctact  taaggagag  420
aaaaacatt  ccaatgaca  cagaaccaa  tccttgcag  ctcgctgta  aatggtgga  480
ccctttgac  ggtggggga  gaaactgat  atcggttcc  tcccagccc  tgcggtaca  540
gcccttgat  gcccaggag  gggatcccg  cctgaagct  cccgacttc  cctactgca  600
cctggaacg  ctaggccgg  ccaggtgca  ggggagctc  agcgagacc  tcacaccac  660
gctttcaag  ttgatgctg  gaagctgca  tatcacaga  aaattttga  caaaaacgg  720
ctgattaca  tgcagtccc  tgtgatccg  ttacccact  gagcccagc  acactcaat  780
ctcctccta  tgaaccggt  tcatgtgga  aggaggagc  aatacgaca  cctcatgga  840
aagctttcg  tcatgctga  cacacggac  aaccacata  agacgctgg  aaagctgag  900
gaagagctg  ggctgtgcg  aaggacgtt  aagcgtctg  accagtata  gctgaacgc  960
gggctagcc  aggtggtgt  tcttcgctt  caagagatc  accctgaat  tggaccttg  1020
aagacaaag  aagggaccg  cgtcatggt  cggtgcctc  agctgctga  ggaatttaa  1080
cggaatgac  atgatgatg  cgaggacga  gaggtcatc  ccaagacag  gcctccagt  1140
gacattgtg  tcgagcggg  tatgctcac  cagacctac  acctcattg  gcgcagagg  1200
acgaaagga  tttcccaag  tgaaatccg  gtggctatg  atgtgggaa  actagaagc  1260
agaatgctg  gccgacttc  tcaaagatt  aaagttgtc  agggattca  ggaagacga  1320
ggtcggcag  gaaccacca  gtacatttc  tgcgtgttt  cagaggaga  cgacctaag  1380
cggcagtac  aaagagaga  ggcccgcag  gagctcttg  ccaccgtga  cctggcgtc  1440
atgcaggag  agtcgcttc  gcctgaagg  gaggacacc  tcctctctg  gtcggacag  1500
gaggaggag  ggagcagca  caagcggag  ggcagaggg  cccagaaag  cacaagagc  1560
tctgcaaac  tccggccca  gacccagcc  catcactcc  ccccaacca  gggtgggtg  1620
aaagttgta  acctacacc  attgaaaaa  cagccgccc  ccttcccag  agctgctga  1680
gagagagcc  gccagagcc  tgccagcag  gacagcctc  tagatacca  cagcgtctc  1740
gaacccaac  tgtcctttg  ctcccactg  gcggacagc  acagtggtg  catagctgt  1800
atcgaggag  tccggatgg  aaacccaaa  gagagtagc  gttccctga  gactgggag  1860
cacagctca  gccaagaca  accacacga  acttaccga  tgctgaaac  caggaatct  1920
atcatagaa  ctgtcacca  tcttcgctt  atcgagagt  tattcacga  tcagaagat  1980
atcatggat  aggagaagc  ggaaggcgt  tccaccaag  gctgcaaga  gtccattgt  2040
cgcttggtg  ggaacctgt  tgaggaagg  ctcttgcga  tgtatcgga  cactgtcat  2100
caagatggc  tcaagaaga  ggtggatct  gtggtgcac  cgtccatgg  ccagaacga  2160
cctctagtg  gaagtgcca  cgagcaggt  cgcttccgg  tctccaatt  aagcacagc  2220
aacagggtt  aaacttccc  gcctccagt  ccccaaggg  aggcagaag  agacagtca  2280
ggaaaagag  gcccaagtg  atcagggga  tctcagctg  gtgcttcct  tagatcaga  2340
agtggacgg  tgaaaaaaa  tgataataa  atgggcata  ccccgctta  aaattatca  2400
cccattgta  ttcccggac  ggggcgttc  ctaggattt  tgcccaaaa  gcctcgcct  2460
cgggtggtc  acatgtttc  gtggtacct  atctacggg  accctgcca  caacaccgt  2520
gagaagcca  gcttcatca  tgaacggag  acgataaag  aggagtcag  cagggcagg  2580
gtccggccg  cctcctctg  aagtgcctg  gaggcctgc  ctgaagccc  atctaaagg  2640
agccaagat  gtgtcacct  ggaggctga  gtggagctt  ccacggaga  agtgtatgt  2700
gacgatgcc  cgtggatgc  ctacatccc  ccaatccca  tccacaggg  cttcggctt  2760
ggctgggct  tcgtcagcg  catcctcct  tgccttccc  tctccatct  catccagat  2820
gtgcaagtc  gctacaagg  ggacaacct  gaggaattt  tgaacgacc  gctgaagaa  2880
cacacgctg  tccgctttc  ccccaggcc  attcggcag  agcttctgt  caagaggcg  2940
tacattttt  cggtggtgg  gaaccttca  aggctgtgc  acatggggg  gctacagtt  3000
ggtcccacg  aaaagtttc  ggataaaga  caggtcttt  tcttcttga  gaagaatgc  3060
gtcattgtt  acactacca  ctgcgaccc  cattacaac  tgggccgca  gaggcggcc  3120
ttcgagagg  gcctctatg  cctgaactc  atgcaggat  tggaaaact  ctggtttga  3180
ctgcagtgc  tctgcctca  caccccact  ggcgtggtg  gctgcccgc  cgtcaggaa  3240
aacagcagc  cagaccagg  cagcgacga  gagggcagc  tgcagaagg  gcaggagag  3300
gccatggac  agcacaacc  ggagcgcaa  tgcgccatg  tggagtaca  cactggaag  3360
cgtgaggtg  tggatgaag  cttgatccc  ggagatggg  tgggtgccg  agggctcga  3420
tccagcttc  acggacacc  caagcgcaa  tggatctgg  ccagctaca  catcaacca  3480
gccaaaaag  agaacactg  cgcagagaa  ggactcaca  tgaggctcc  gacatttct  3540
tccaagcgc  caatgcccc  cagtgccag  ggcaacagc  ggttgaata  ttgggggga  3600
gcaagagta  gctccgagc  ctgtgctgg  tgggaagag  agtttgagg  ggaccgaga  3660
ccctcgctg  accgaaacc  gagagtgag  ggtgggaaa  gccagaagc  gaagcggct  3720
aagaaggac  ctgggaaga  gatcaagag  aagaagaaa  gagagttcc  aggagaaaa  3780
agcaaaagg  tgcgctacc  tgatgaagc  gaccagagt  ccctgcatc  gatgacgcg  3840
cttcgtgtc  cctggtcta  gcaggagga  gggctgctt  tgctgtgcc  cattgccag  3900
aatgtcctc  acaccaagg  gaagggtcc  tttgtcacc  ggcaggtgg  acgggacat  3960
ttgcatgcc  cgtttgaag  gtctttgga  aaaacatct  attcccttg  acgaagagc  4020
cgctacata  tcaaaaacc  acaggccta  ctcaactat  aagtgtgcc  ggccgaggt  4080
taccaggat  aagcacttg  tggagattt  atgaatcga  gaggtgact  tgatgaccc  4140
aaggtttgt  ccaacgagt  taaagaatt  gtggagaag  ttaaagaaa  gttcagttc  4200
gccctaagg  attctaacc  tgaaatccc  gacacactc  aggagctgt  cgccaggta  4260
cgagttttg  caattgggg  tgaaaaaga  caaaccagg  aagaggatg  acttaacag  4320
gtggatgac  tccactttc  ggtgcttca  aacctgatc  agagcacgc  ggccctctc  4380
gacagtcag  tgaagtcct  ccagtcatt  cagactttc  gcctctatc  ggagtacaa  4440
gaccacgtt  ttgtgaagg  cttcatgga  tgccagaag  ggagcttgg  caaccggcg  4500
cgggtcaac  acacgctgg  ccccaagaa  aaccgggcc  tccccttcg  gccaatgtc  4560
taccagcta  cccagacct  ctacaggat  tttacgtgg  gatttccaa  caccatctg  4620
acggagtca  tccagtttt  ggacagaat  cgggctgcc  gcaagttgg  ccagcctga  4680
cgtttctct  tcaaagacc  ggataataa  gagcccaca  acgacatgg  ggccttttc  4740
ctggacggc  ctggaggaa  ttgtgtggc  gtcctgacc  tcttctctc  gggcctcat  4800
tctgtggat  tcaggatcc  ggagcagat  atcgtggta  acagctcaa  ggtggagaa  4860
gaggtcatc  aaagcttgg  gaaggacgg  agcctggag  atgacgagg  tgaagagga  4920
gacttggac  aaggtgtag  gggcaagcg  cggagcatg  aggtgaaac  tgcgcaagc  4980
tcccacacc  actacctgc  gatgagggg  tactactcc  ccggcatcg  cagcacccg  5040
aacctcaac  ccaacgaca  cattgtggt  aactcctgc  agatgaagt  ccagctccg  5100
tgcacccct  tgcccgccc  gctcaggcc  gctgccgct  ctctggaag  gctaacaat  5160
ggaacctcc  gcctccctg  tacgttcac  aagctgata  acccccagg  aaacacctg  5220
agcttggag  agtttgtcc  ccagctgga  ctgtctggg  atagtcccg  agacctgac  5280
gctgccttg  agatcttgg  agccattat  gccacgggt  gttttggga  tgacaagga  5340
gagctgcgc  gacggttct  ggccttgga  aaggcaggt  gtgggcgca  caggacatt  5400
gcagattgc  tccaggccc  cctggagca  catcaggtg  tggaggtcg  tggcaacac  5460
gcgcgcctg  tagccatgg  ctctgcctg  ccttggctc  tgcactccg  gcggctgaa  5520
gacagagaa  acgccgaca  ccagagaga  gacccccag  ccagacccc  ggaggggtc  5580
tccagtgag  acagccccc  cgaggggca  gcacctcct  ctcacagcc  ccggggcac  5640
aagaggcgc  ccagctggg  cagtgagaa  ggggagacc  acgccgagg  cacccagat  5700
acccctgcc  agaggccag  gctccagga  tcaaatttg  cccccagcc  tgggcccgg  5760
gctgaagat  gggcagaag  ccaggcccc  tctccaccc  cagctcttg  agacaccgc  5820
gcagcggga  cagcacagg  agaccaaga  ggtgtcggt  agttcagtt  cccaggcca  5880
gagcagctg  gcggccagg  gcagcctcc  gagggctct  aagacccca  agggttcac  5940
gagagtttc  gagctgcca  catctccca  gcagcacgg  aaagggact  tgagagtgt  6000
tgcttcatc  gccggccgt  gcgtgtcgt  gatggccac  tgaaccttc  tgtatgcaa  6060
ggtatgatg  aggccatgc  gtaccacat  atgaccagg  ctggcatcc  cgagagctc  6120
ctgctgcgc  actaccagg  ggtcctgca  cccgtcgcc  tgctggagt  gctccaggg  6180
ctggagtcc  tcggctgca  ccggaagcg  tggctgaga  agccaaggc  tgtctcgct  6240
ttctctaca  ccgtggtgg  agaggtgga  gtgccctcc  gcctggacg  gagccccat  6300
gctttctat  agcccacct  ggactgtac  ctccggctg  gccgtgtgt  cccccacga  6360
gtcaactgg  acaagtgga  ccacctcta  gacccctgt  ggcgtcccc  ccctcccag  6420
caccgcctg  cacaccact  ctgcctggt  ctcggcaga  cccactgtg  cctggcctt  6480
ggtctgccg  gcctcctgc  gcaggggac  ggtgctttg  ccagagtca  agactgaca  6540
gtttcccac  gtactggaa  tctggaaag  ggggctccc  gacctgccc  tcccccagg  6600
tcttctggg  cttcccctt  ggaactggc  tcatcacac  gggagttgg  gcttcttgt  6660
tctgggtct  cagagtttg  cccgcctgt  cacacctca  attccagac  ctagccatc  6720
cggcaggat  tcctggctc  ttgagtgcc  aggtgccac  aagaggaag  gccttgtgg  6780
atacacctt  cagaatagg  atcggtgtg  cccgctgcg  ggggccccc  atgggggct  6840
tggcccctc  gcaggcagg  catcccaac  cctggctgg  actgaacca  ccagagcgg  6900
gcggctccc  tttcagcct  gtgagtcac  tggcaggcc  cagctgggc  ggctgtccg  6960
gtccctcag  ctggctggt  attccttgc  ggaggg  6996



<210> 3152
<211> 2110
<212> PRT
<213> Homo sapiens
<308> U02619
<400> 3152

Met Asp Ala Leu Glu Ser Leu Leu Asp Glu Val Ala Leu Glu Gly Leu 
  1               5                  10                  15
Asp Gly Leu Cys Leu Pro Ala Leu Trp Ser Arg Leu Glu Thr Arg Val 
             20                  25                  30
Pro Pro Phe Pro Leu Pro Leu Glu Pro Cys Thr Gln Glu Phe Leu Trp 
         35                  40                  45
Arg Ala Leu Ala Thr His Pro Gly Ile Ser Phe Tyr Glu Glu Pro Arg 
     50                  55                  60
Glu Arg Pro Asp Leu Gln Leu Gln Asp Arg Tyr Glu Glu Ile Asp Leu 
 65                  70                  75                  80
Glu Thr Gly Ile Leu Glu Ser Arg Arg Asp Pro Val Ala Leu Glu Asp 
                 85                  90                  95
Val Tyr Pro Ile His Met Ile Leu Glu Asn Lys Asp Gly Ile Gln Gly 
             100                105                110
Ser Cys Arg Tyr Phe Lys Glu Arg Lys Asn Ile Thr Asn Asp Ile Arg 
         115                120                125
Thr Lys Ser Leu Gln Pro Arg Cys Thr Met Val Glu Pro Phe Asp Arg 
     130                135                140
Trp Gly Lys Lys Leu Ile Ile Gly Ser Leu Pro Ala His Ala Val Gln 
 145                150                155                160
Ala Leu Asp Ser Pro Gly Gly Gly Ser Arg Pro Glu Ala Ala Arg Leu 
                 165                170                175
Leu Leu Leu His Pro Gly Thr Ala Arg Pro Val Gln Val Gln Gly Glu 
             180                185                190
Leu Gln Arg Asp Leu His Thr Thr Ala Phe Lys Val Asp Ala Gly Lys 
         195                200                205
Leu His Tyr His Arg Lys Ile Leu Asn Lys Asn Gly Leu Ile Thr Met 
     210                215                220
Gln Ser His Val Ile Arg Leu Pro Thr Gly Ala Gln Gln His Ser Ile 
 225                230                235                240
Leu Leu Leu Leu Asn Arg Phe His Val Asp Arg Arg Ser Lys Tyr Asp 
                 245                250                255
Ile Leu Met Glu Lys Leu Ser Val Met Leu Ser Thr Arg Thr Asn His 
             260                265                270
Ile Glu Thr Leu Gly Lys Leu Arg Glu Glu Leu Gly Leu Cys Glu Arg 
         275                280                285
Thr Phe Lys Arg Leu Tyr Gln Tyr Met Leu Asn Ala Gly Leu Ala Lys 
     290                295                300
Val Val Ser Leu Arg Leu Gln Glu Ile His Pro Glu Cys Gly Pro Cys 
 305                310                315                320
Lys Thr Lys Lys Gly Thr Asp Val Met Val Arg Cys Leu Lys Leu Leu 
                 325                330                335
Lys Glu Phe Lys Arg Asn Asp His Asp Asp Asp Glu Asp Glu Glu Val 
             340                345                350
Ile Ser Lys Thr Val Pro Pro Val Asp Ile Val Phe Glu Arg Asp Met 
         355                360                365
Leu Thr Gln Thr Tyr Asp Leu Ile Glu Arg Arg Gly Thr Lys Gly Ile 
     370                375                380
Ser Gln Ala Glu Ile Arg Val Ala Met Asn Val Gly Lys Leu Glu Ala 
 385                390                395                400
Arg Met Leu Cys Arg Leu Leu Gln Arg Phe Lys Val Val Lys Gly Phe 
                 405                410                415
Met Glu Asp Glu Gly Arg Gln Arg Thr Thr Lys Tyr Ile Ser Cys Val 
             420                425                430
Phe Ala Glu Glu Ser Asp Leu Ser Arg Gln Tyr Gln Arg Glu Lys Ala 
         435                440                445
Arg Ser Glu Leu Leu Thr Thr Val Ser Leu Ala Ser Met Gln Glu Glu 
     450                455                460
Ser Leu Leu Pro Glu Gly Glu Asp Thr Phe Leu Ser Glu Ser Asp Ser 
 465                470                475                480
Glu Glu Glu Arg Ser Ser Ser Lys Arg Arg Gly Arg Gly Ser Gln Lys 
                 485                490                495
Asp Thr Arg Ala Ser Ala Asn Leu Arg Pro Lys Thr Gln Pro His His 
             500                505                510
Ser Thr Pro Thr Lys Gly Gly Trp Lys Val Val Asn Leu His Pro Leu 
         515                520                525
Lys Lys Gln Pro Pro Ser Phe Pro Gly Ala Ala Glu Glu Arg Ala Cys 
     530                535                540
Gln Ser Leu Ala Ser Arg Asp Ser Leu Leu Asp Thr Ser Ser Val Ser 
 545                550                555                560
Glu Pro Asn Val Ser Phe Val Ser His Cys Ala Asp Ser Asn Ser Gly 
                 565                570                575
Asp Ile Ala Val Ile Glu Glu Val Arg Met Glu Asn Pro Lys Glu Ser 
             580                585                590
Ser Ser Ser Leu Lys Thr Gly Arg His Ser Ser Gly Gln Asp Lys Pro 
         595                600                605
His Glu Thr Tyr Arg Leu Leu Lys Arg Arg Asn Leu Ile Ile Glu Ala 
     610                615                620
Val Thr Asn Leu Arg Leu Ile Glu Ser Leu Phe Thr Ile Gln Lys Met 
 625                630                635                640
Ile Met Asp Gln Glu Lys Gln Glu Gly Val Ser Thr Lys Cys Cys Lys 
                 645                650                655
Lys Ser Ile Val Arg Leu Val Arg Asn Leu Ser Glu Glu Gly Leu Leu 
             660                665                670
Arg Leu Tyr Arg Thr Thr Val Ile Gln Asp Gly Ile Lys Lys Lys Val 
         675                680                685
Asp Leu Val Val His Pro Ser Met Asp Gln Asn Asp Pro Leu Val Arg 
     690                695                700
Ser Ala Ile Glu Gln Val Arg Phe Arg Ile Ser Asn Ser Ser Thr Ala 
 705                710                715                720
Asn Arg Val Lys Thr Ser Gln Pro Pro Val Pro Gln Gly Glu Ala Glu 
                 725                730                735
Glu Asp Ser Gln Gly Lys Glu Gly Pro Ser Gly Ser Gly Asp Ser Gln 
             740                745                750
Leu Ser Ala Ser Ser Arg Ser Glu Ser Gly Arg Met Lys Lys Ser Asp 
         755                760                765
Asn Lys Met Gly Ile Thr Pro Leu Arg Asn Tyr His Pro Ile Val Val 
     770                775                780
Pro Gly Leu Gly Arg Ser Leu Gly Phe Leu Pro Lys Met Pro Arg Leu 
 785                790                795                800
Arg Val Val His Met Phe Leu Trp Tyr Leu Ile Tyr Gly His Pro Ala 
                 805                810                815
Ser Asn Thr Val Glu Lys Pro Ser Phe Ile Ser Glu Arg Arg Thr Ile 
             820                825                830
Lys Gln Glu Ser Gly Arg Ala Gly Val Arg Pro Ser Ser Ser Gly Ser 
         835                840                845
Ala Trp Glu Ala Cys Ser Glu Ala Pro Ser Lys Gly Ser Gln Asp Gly 
     850                855                860
Val Thr Trp Glu Ala Glu Val Glu Leu Ala Thr Glu Thr Val Tyr Val 
 865                870                875                880
Asp Asp Ala Ser Trp Met Arg Tyr Ile Pro Pro Ile Pro Val His Arg 
                 885                890                895
Asp Phe Gly Phe Gly Trp Ala Leu Val Ser Asp Ile Leu Leu Cys Leu 
             900                905                910
Pro Leu Ser Ile Phe Ile Gln Ile Val Gln Val Ser Tyr Lys Val Asp 
         915                920                925
Asn Leu Glu Glu Phe Leu Asn Asp Pro Leu Lys Lys His Thr Leu Ile 
     930                935                940
Arg Phe Leu Pro Arg Pro Ile Arg Gln Gln Leu Leu Tyr Lys Arg Arg 
 945                950                955                960
Tyr Ile Phe Ser Val Val Glu Asn Leu Gln Arg Leu Cys Tyr Met Gly 
                 965                970                975
Val Leu Gln Phe Gly Pro Thr Glu Lys Phe Gln Asp Lys Asp Gln Val 
             980                985                990
Phe Ile Phe Leu Lys Lys Asn Ala Val Ile Val Asp Thr Thr Ile Cys 
         995                1000                1005
Asp Pro His Tyr Asn Leu Gly Arg Arg Arg Arg Pro Phe Glu Arg Arg 
     1010                1015                1020
Leu Tyr Val Leu Asn Ser Met Gln Asp Val Glu Asn Tyr Trp Phe Asp 
 1025                1030                1035                1040
Leu Gln Cys Val Cys Leu Asn Thr Pro Leu Gly Val Val Arg Cys Pro 
                 1045                1050                1055
Arg Val Arg Lys Asn Ser Ser Thr Asp Gln Gly Ser Asp Glu Glu Gly 
             1060                1065                1070
Ser Leu Gln Lys Glu Gln Glu Ser Ala Met Asp Lys His Asn Leu Glu 
         1075                1080                1085
Arg Lys Cys Ala Met Leu Glu Tyr Thr Thr Gly Ser Arg Glu Val Val 
     1090                1095                1100
Asp Glu Gly Leu Ile Pro Gly Asp Gly Leu Gly Ala Ala Gly Leu Asp 
 1105                1110                1115                1120
Ser Ser Phe Tyr Gly His Leu Lys Arg Asn Trp Ile Trp Thr Ser Tyr 
                 1125                1130                1135
Ile Ile Asn Gln Ala Lys Lys Glu Asn Thr Ala Ala Glu Asn Gly Leu 
             1140                1145                1150
Thr Val Arg Leu Gln Thr Phe Leu Ser Lys Arg Pro Met Pro Leu Ser 
         1155                1160                1165
Ala Arg Gly Asn Ser Arg Leu Asn Ile Trp Gly Glu Ala Arg Val Gly 
     1170                1175                1180
Ser Glu Leu Cys Ala Gly Trp Glu Glu Gln Phe Glu Val Asp Arg Glu 
 1185                1190                1195                1200
Pro Ser Leu Asp Arg Asn Arg Arg Val Arg Gly Gly Lys Ser Gln Lys 
                 1205                1210                1215
Arg Lys Arg Leu Lys Lys Asp Pro Gly Lys Lys Ile Lys Arg Lys Lys 
             1220                1225                1230
Lys Gly Glu Phe Pro Gly Glu Lys Ser Lys Arg Leu Arg Tyr His Asp 
         1235                1240                1245
Glu Ala Asp Gln Ser Ala Leu His Arg Met Thr Arg Leu Arg Val Thr 
     1250                1255                1260
Trp Ser Met Gln Glu Asp Gly Leu Leu Val Leu Cys Arg Ile Ala Ser 
 1265                1270                1275                1280
Asn Val Leu Asn Thr Lys Val Lys Gly Pro Phe Val Thr Trp Gln Val 
                 1285                1290                1295
Val Arg Asp Ile Leu His Ala Thr Phe Glu Glu Ser Leu Asp Lys Thr 
             1300                1305                1310
Ser His Ser Leu Gly Arg Arg Ala Arg Tyr Ile Val Lys Asn Pro Gln 
         1315                1320                1325
Ala Tyr Leu Asn Tyr Lys Val Cys Leu Ala Glu Val Tyr Gln Asp Lys 
     1330                1335                1340
Ala Leu Val Gly Asp Phe Met Asn Arg Arg Gly Asp Tyr Asp Asp Pro 
 1345                1350                1355                1360
Lys Val Cys Ala Asn Glu Phe Lys Glu Phe Val Glu Lys Leu Lys Glu 
                 1365                1370                1375
Lys Phe Ser Ser Ala Leu Arg Asn Ser Asn Leu Glu Ile Pro Asp Thr 
             1380                1385                1390
Leu Gln Glu Leu Phe Ala Arg Tyr Arg Val Leu Ala Ile Gly Asp Glu 
         1395                1400                1405
Lys Asp Gln Thr Arg Lys Glu Asp Glu Leu Asn Ser Val Asp Asp Ile 
     1410                1415                1420
His Phe Leu Val Leu Gln Asn Leu Ile Gln Ser Thr Leu Ala Leu Ser 
 1425                1430                1435                1440
Asp Ser Gln Met Lys Ser Tyr Gln Ser Phe Gln Thr Phe Arg Leu Tyr 
                 1445                1450                1455
Arg Glu Tyr Lys Asp His Val Leu Val Lys Ala Phe Met Glu Cys Gln 
             1460                1465                1470
Lys Arg Ser Leu Val Asn Arg Arg Arg Val Asn His Thr Leu Gly Pro 
         1475                1480                1485
Lys Lys Asn Arg Ala Leu Pro Phe Val Pro Met Ser Tyr Gln Leu Ser 
     1490                1495                1500
Gln Thr Tyr Tyr Arg Ile Phe Thr Trp Arg Phe Pro Ser Thr Ile Cys 
 1505                1510                1515                1520
Thr Glu Ser Phe Gln Phe Leu Asp Arg Met Arg Ala Ala Gly Lys Leu 
                 1525                1530                1535
Asp Gln Pro Asp Arg Phe Ser Phe Lys Asp Gln Asp Asn Asn Glu Pro 
             1540                1545                1550
Thr Asn Asp Met Val Ala Phe Ser Leu Asp Gly Pro Gly Gly Asn Cys 
         1555                1560                1565
Val Ala Val Leu Thr Leu Phe Ser Leu Gly Leu Ile Ser Val Asp Val 
     1570                1575                1580
Arg Ile Pro Glu Gln Ile Ile Val Val Asp Ser Ser Met Val Glu Asn 
 1585                1590                1595                1600
Glu Val Ile Lys Ser Leu Gly Lys Asp Gly Ser Leu Glu Asp Asp Glu 
                 1605                1610                1615
Asp Glu Glu Asp Asp Leu Asp Glu Gly Val Gly Gly Lys Arg Arg Ser 
             1620                1625                1630
Met Glu Val Lys Pro Ala Gln Ala Ser His Thr Asn Tyr Leu Leu Met 
         1635                1640                1645
Arg Gly Tyr Tyr Ser Pro Gly Ile Val Ser Thr Arg Asn Leu Asn Pro 
     1650                1655                1660
Asn Asp Ser Ile Val Val Asn Ser Cys Gln Met Lys Phe Gln Leu Arg 
 1665                1670                1675                1680
Cys Thr Pro Val Pro Ala Arg Leu Arg Pro Ala Ala Ala Pro Leu Glu 
                 1685                1690                1695
Glu Leu Thr Met Gly Thr Ser Cys Leu Pro Asp Thr Phe Thr Lys Leu 
             1700                1705                1710
Ile Asn Pro Gln Glu Asn Thr Cys Ser Leu Glu Glu Phe Val Leu Gln 
         1715                1720                1725
Leu Glu Leu Ser Gly Tyr Ser Pro Glu Asp Leu Thr Ala Ala Leu Glu 
     1730                1735                1740
Ile Leu Glu Ala Ile Ile Ala Thr Gly Cys Phe Gly Ile Asp Lys Glu 
 1745                1750                1755                1760
Glu Leu Arg Arg Arg Phe Ser Ala Leu Glu Lys Ala Gly Gly Gly Arg 
                 1765                1770                1775
Thr Arg Thr Phe Ala Asp Cys Ile Gln Ala Leu Leu Glu Gln His Gln 
             1780                1785                1790
Val Leu Glu Val Gly Gly Asn Thr Ala Arg Leu Val Ala Met Gly Ser 
         1795                1800                1805
Ala Trp Pro Trp Leu Leu His Ser Val Arg Leu Lys Asp Arg Glu Asp 
     1810                1815                1820
Ala Asp Ile Gln Arg Glu Asp Pro Gln Ala Arg Pro Leu Glu Gly Ser 
 1825                1830                1835                1840
Ser Ser Glu Asp Ser Pro Pro Glu Gly Gln Ala Pro Pro Ser His Ser 
                 1845                1850                1855
Pro Arg Gly Thr Lys Arg Arg Ala Ser Trp Ala Ser Glu Asn Gly Glu 
             1860                1865                1870
Thr Asp Ala Glu Gly Thr Gln Met Thr Pro Ala Lys Arg Pro Ala Leu 
         1875                1880                1885
Gln Asp Ser Asn Leu Ala Pro Ser Leu Gly Pro Gly Ala Glu Asp Gly 
     1890                1895                1900
Ala Glu Ala Gln Ala Pro Ser Pro Pro Pro Ala Leu Glu Asp Thr Ala 
 1905                1910                1915                1920
Ala Ala Gly Ala Ala Gln Glu Asp Gln Glu Gly Val Gly Glu Phe Ser 
                 1925                1930                1935
Ser Pro Gly Gln Glu Gln Leu Ser Gly Gln Ala Gln Pro Pro Glu Gly 
             1940                1945                1950
Ser Glu Asp Pro Arg Gly Phe Thr Glu Ser Phe Gly Ala Ala Asn Ile 
         1955                1960                1965
Ser Gln Ala Ala Arg Glu Arg Asp Cys Glu Ser Val Cys Phe Ile Gly 
     1970                1975                1980
Arg Pro Trp Arg Val Val Asp Gly His Leu Asn Leu Pro Val Cys Lys 
 1985                1990                1995                2000
Gly Met Met Glu Ala Met Leu Tyr His Ile Met Thr Arg Pro Gly Ile 
                 2005                2010                2015
Pro Glu Ser Ser Leu Leu Arg His Tyr Gln Gly Val Leu Gln Pro Val 
             2020                2025                2030
Ala Val Leu Glu Leu Leu Gln Gly Leu Glu Ser Leu Gly Cys Ile Arg 
         2035                2040                2045
Lys Arg Trp Leu Arg Lys Pro Arg Pro Val Ser Leu Phe Ser Thr Pro 
     2050                2055                2060
Val Val Glu Glu Val Glu Val Pro Ser Ser Leu Asp Glu Ser Pro Met 
 2065                2070                2075                2080
Ala Phe Tyr Glu Pro Thr Leu Asp Cys Thr Leu Arg Leu Gly Arg Val 
                 2085                2090                2095
Phe Pro His Glu Val Asn Trp Asn Lys Trp Ile His Leu Ter 
             2100                2105                2110



<210> 3153
<211> 6878
<212> DNA
<213> Rattus norvegicus
<308> L28801
<400> 3153

gccggggct  ctaactgaa  aggccatgg  cgcgctcga  tcgttgttg  acgaggtgg  60
cctggaggg  ctcgacggc  tgtgcctgc  cgcgctgtg  agccgcctg  aatcccgct  120
gcctgcctt  cctttgccg  tggaaccct  cacgcagga  tttctgtgg  gggccttag  180
cacgcaccc  ggcatcagt  tctacgagg  gccgcgaga  cgacctgac  tgcagctcc  240
agaccgata  gaagaaatc  acttggaaa  tggaatttt  gagtccagg  gggacccag  300
cactctgga  gatgtctac  ccattcata  gatcttaga  aataaggat  gcatccagg  360
ctcctgccg  tactttaag  agagaaagg  catcaccag  agcatcagg  gcaagtgtt  420
gcagcctcg  tgtacaatg  tagaagcct  cagcaggtg  ggtaagaag  tcatcattg  480
ggcttccca  gacatgcga  accgggcct  gataggcct  gagggggat  ctgatctga  540
gcttcctga  ttctcctac  gcattttgg  gcggttagg  cgatcgaga  ggcaagggg  600
gctgcaacg  gaccttcac  ccaccgctt  caaggtcga  gctgggaag  ttcattatc  660
caggaaaat  ttgaacaag  atgggctca  tacaatgca  tcacacgtg  tccgactgc  720
tactggagc  cagcaacac  ccatcctcc  cctccttaa  cggtttcat  tagacagga  780
gagcaagta  gacatcctc  tggagaagc  gtctatgat  ctgagcaca  ggagcaacc  840
gatcgagac  ctgggcaag  tgagggagg  gctgggact  tgtgaaagg  cgttcaagc  900
tctgtacca  tacatgctg  atgctgggc  ggccaaagt  gtgtccctt  ccttgcagg  960
gattcaccc  gagtgtggt  cctgtaaga  caagaaagg  actgatgtc  tggttcggt  1020
ccttaagct  ctgaaggag  tcaggcgaa  gatggaaga  gaccatgac  acgatgacg  1080
tgaagaggc  atctccaag  ctgtacctc  cgtggacat  gtgtttgag  gggacatgc  1140
cacgcagac  tacgagctc  ttgagcgca  aggaacgaa  ggaatttcc  aagctgaga  1200
ccgagttgc  atgaatgtg  gaaaactgg  agcaagaat  ctgtgtcgg  tccttcaga  1260
gttcaaggt  gtcaaggga  tcatggaag  tgaaggccg  cagaggacc  ccaagtaca  1320
ttcctgtgt  tttgcggag  agagtgact  gagccgcca  tatgcgcgt  aaaaggccc  1380
aggagagct  ctaaccact  tgagcctcg  ctcagtgca  gatgaatcc  tcatgcctg  1440
gggtgaaga  gccttcctc  ctgactccg  aagtgagga  gagagcagc  gcagtggca  1500
gcgtagggg  cgagggtcc  gggggcatt  aagagcctc  ggggatgct  ggcctggct  1560
tcggcctca  cactccact  cagccaagg  cgggtggaa  gtcctaaat  tgcacccat  1620
aaagaagcc  aaaagtgcc  ctgtggaaa  atcccgccg  agctctgct  gtagggatg  1680
cctggacac  agcagctca  ccgagctca  tataccctt  gaccctcac  gcatggaca  1740
tcacagtgg  gacatcgct  tgattgagg  ggtccggct  gataacccc  aggagggtg  1800
tggctccca  aagggcgga  ggcatggct  aggccagga  aagcctcac  aaacatacc  1860
actgctaaa  cgcagaaat  tgattatag  agctgtcac  aacctccgc  tgattgaga  1920
cctgttcac  attcagaag  tgatcatgg  ccaggagaa  caagagggt  tctccacca  1980
atgctgtaa  aagtccatt  tccgcttgg  gcggaacct  tctgaggag  gtctcttga  2040
attgtatag  actacagtc  ttcaagatg  catcaagaa  aaggtagac  tggtcgtgc  2100
cccttccat  gaccagaat  accctcttg  gagaagtgc  attgagcag  ttcgcttcc  2160
gatctccaa  tcaagcaca  caaacaggg  taaagttcc  ccggcccca  caccccaag  2220
ggaagcaga  gagggaaac  aagaaccag  ggtcccaag  agatcagca  actctgaag  2280
gaacacatc  tcgaagcca  aaagcacac  ggtgaaaaa  acagatgag  aaatgggca  2340
aaccccact  aagaattac  aacctgtca  agttcctgg  cttgggcgc  ccatagggt  2400
ccttcccaa  atgccacgc  ttcgggtga  gcacctgtt  ctgtggtac  tggtgtatg  2460
gcatcctgc  agccacact  gggaacagc  tactttcca  agtgagagg  aaacaggca  2520
gcaggagcc  agcagacca  gggtccagc  ctcctcagg  gatgactgg  actcctctg  2580
agccaaaaa  agcacagaa  gcagctcct  ggaggcaga  atggaactc  ccacagaga  2640
agtgtatgt  gatgagatc  catggatgc  ctacgtccc  cccatcccc  tccacagag  2700
cttcggctt  ggctgggct  ttgtcagtg  cattcttct  tgccttccc  tctccatct  2760
tgtccaagt  gttcaagtc  gctacaagg  ggataacct  gaggatttt  tgaatgacc  2820
tctgaagaa  cacacactg  tccgcttcc  ccctaggca  atccggcag  agctactgt  2880
taagaggcg  tatattttc  cggtggtgg  gaacctgca  cggctgtgc  acatggggc  2940
gctacagtt  ggacccaca  agaagtttc  ggataaaga  caggtcttt  ttttcctga  3000
gaagaatgc  gtcattgtg  acaccacca  ctgtgaccc  cattacaac  tggcccaca  3060
cagccggcc  tttgagaga  gtctctacg  cttggattc  atgcaggat  tggaaagct  3120
ctggtttga  ctgcagtgt  tctgcctaa  caccccact  ggtgtggtg  gttgtccat  3180
tgcacagaa  atctgccct  atccgggca  tgacccaga  ggcagcttg  ggaaggagc  3240
agagagcgc  atggacaag  acaacctag  gcgcaagtg  gccatgctg  agtatacca  3300
ggggagccg  gaagttgtg  atgaaggct  agtccctgg  gatggactg  gagctgctg  3360
gctggactc  agcttctat  cacacctga  gcgcaactg  gtctggacc  gctatatca  3420
caacaaagc  agaaagaac  acacctccg  aaatgggct  acaggaaga  tccagactt  3480
cctgtctaa  cgcccaatg  cacttgggt  tggaggcag  ggccgtctg  ctctctggt  3540
agaggggaa  gctgatgct  agctctgtg  tgacaaaga  gaacacttt  aactggacc  3600
agaacctac  cctggcagg  accgaaaag  gcgtggggg  aagagtcag  agcggaagc  3660
gctgaagaa  gagcccatc  ggaagacca  gcgaaggag  agaggagag  atccagaag  3720
caaaagcaa  aaactacgc  accaagatg  ggctgacca  aacgccctc  ggatgatga  3780
ccggcttcg  gtttcttgg  ccatgcagg  ggatgggtt  ctaatgctc  gccgaattg  3840
cagcaatgt  ctcaacacc  aggtgaaag  accatttgt  acctggcag  tcgtgcgtg  3900
cattttgca  gctaccttt  aagagtctt  ggataaaac  tctcactcg  ttggacgaa  3960
agctcgcta  atagtcaaa  atccccagg  ctttatgaa  tacaaagtc  gcctggcag  4020
agtgtacca  gataaggca  tcgttggag  tttcatgag  cggaaggat  actacgaag  4080
cccaaaggt  tgtgccaag  agtttaaag  atttgtgga  aagctgaaa  agaagttca  4140
ctctggcct  aggaacccc  accttgaga  cccagacac  ctgcaggaa  tctttgcca  4200
ataccgggt  ttggcaatc  gagatgaaa  ggaccgtgt  aggaaggag  atgaactga  4260
tagtgtgga  gacatccac  tcctggtgc  acagaacct  atccagagc  cactgtccc  4320
ctctaacag  cagtccaac  cttgccagt  cttccagat  ttccgcctc  accgggagt  4380
ccgggagcc  gtgctggtg  gggccttca  ggagtgcca  aagaggagc  tggtcaacc  4440
acgccgtgt  agccactcc  agggtccca  gaagaaccg  gctgtgccc  ttgtgccca  4500
gtcctacca  ctctcccag  catactaca  gcttttcac  tggcgattt  ccaccaccg  4560
ctgcaccga  tccttccag  tctatgaca  actacgggc  aacggcata  tagaccagc  4620
tgatcattt  tctttcaag  acatggata  caatgaccc  tcaagtgac  tggtggcgt  4680
ttctttgga  agccctgga  gacactgtg  gacagccct  gccctcttc  ccttgggcc  4740
cctctctgt  gatgtccga  tcccagagc  gattgtggt  gtagacagc  ccatggtgg  4800
gagtgaggt  atgaagagc  tggggaaag  tggcggctt  gatgatgat  atgaggagg  4860
agacctgga  gaaggttca  ggaccaagc  tcagagtgt  gaagtaaag  cccatcagg  4920
ctcacacac  aagtacctg  tgatgagag  ttactacac  gtgcctggc  tggtcagca  4980
gcgcaacct  aaccccaat  acagcattg  ggtcaattc  tgccaggtt  aattccgac  5040
gcgcaatac  cctgcaccc  cccatcttg  gcccactgg  cccacagcc  caccgctag  5100
agagctcca  gctggccct  cctgcctcc  tgcctcctt  accagcctg  tggatccac  5160
gctgcacac  cgctgccca  aagagtttg  ccaccagat  gcacagtct  ggtacagcc  5220
tgaggacgt  gctgcgtcc  tagagatcc  gcaggctgt  gcagctgct  actgcttcg  5280
ggttgacag  gagaagctg  gcagacagt  ctctgcctt  gagaagata  cggacaagc  5340
caccaggac  ttcctggac  atatccagg  cctcttgga  cagcaacaa  tcatggaag  5400
tggaggcaa  actgtgcgc  tagtggcca  ggcctctgc  cagccctgg  tcctgcctt  5460
agtgcgtct  aaagatgtg  aaatagaca  caaggcctc  ggggatgac  gccaatcta  5520
actccctgc  gggtcttcc  tcgaagacc  cacctctga  ggtgcacca  ttcctccag  5580
cagctccaa  ggcactaaa  agcgcccct  ctgctctat  cagagccct  aaactgatg  5640
tgaggaagc  acaaggctc  ctgccaaga  gcccacatt  caagatgtc  gtgtggctg  5700
cagtcctag  cctggaaca  aagagcaga  agaggccca  gctcagttt  cagctcctg  5760
agatgcagg  gcagagggc  ccaggcagg  gagccaaga  agtgttggt  tctcaggcc  5820
agagcagct  ggctgtgag  tccagcttc  agaaaattc  gaagacccc  gaggactta  5880
agagagcaa  atggcccag  tagcatggg  gagcggctg  gaaagagta  gttttgtcg  5940
tcgcccatg  cgtggtgtg  acgggcgcc  gaacatgcc  gtgtgcaaa  gcatgatgg  6000
agccgtgct  taccacatc  tgtcaaggc  cggtgttcc  gagagctgc  tgctacagt  6060
ctaccaggg  gtcctacag  ctgttgctg  gcttgagct  ctccggggc  tagagtctc  6120
cggctgtat  cagaagcgg  tgctgaaga  gccagcgag  gtctcactc  tctccaggc  6180
tgtggtgga  ggcctaggt  aggccagtg  ggccgaggc  ctctcctgt  aggggagca  6240
tgtcacctt  tatgaacct  ctctggact  taccatccg  ctgggccgt  tcttccccc  6300
tgacatcaa  tggaaacaa  gtggatcca  ttatagatg  gtcccaggc  agcagagga  6360
cctctgccc  tgcttaatt  ttccgcctg  actgtccca  gagccccgt  cttcacaca  6420
ctgttacca  agctcggcc  agcctagca  aggtgtagc  actagcagg  gacttcagt  6480
ccctctgct  tcggctgct  ttggtccca  gtgcccagc  ttcctgcag  cctgtgtcc  6540
gccctggac  caggctcta  catcagcag  atctgcaag  gatgttgtt  agggagcag  6600
ctgatgacc  agccctgag  cacctcaca  gcaccacac  attcagact  agaggaaga  6660
acatcacag  tgtacctgg  agagtctgc  cctcttaag  tagggcatc  caacttggc  6720
tgaactgag  tcaggtctc  agctcccaa  ggcccctcc  gccagaagc  aggcctgta  6780
gttttgctt  tgtttttgt  ttattttgc  ctcttttca  tagatacaa  cccctggca  6840
gtatttatt  attttttaa  taaagtaag  tgaaatgc  6878



<210> 3154
<211> 2149
<212> PRT
<213> Rattus norvegicus
<308> L28801
<400> 3154

Met Asp Ala Leu Glu Ser Leu Leu Asp Glu Val Ala Leu Glu Gly Leu 
  1               5                  10                  15
Asp Gly Leu Cys Leu Pro Ala Leu Trp Ser Arg Leu Glu Ser Arg Ser 
             20                  25                  30
Pro Ala Phe Pro Leu Pro Leu Glu Pro Tyr Thr Gln Glu Phe Leu Trp 
         35                  40                  45
Arg Ala Leu Val Thr His Pro Gly Ile Ser Phe Tyr Glu Glu Pro Arg 
     50                  55                  60
Glu Arg Pro Asp Leu Gln Leu Gln Asp Arg Tyr Glu Glu Ile Asp Leu 
 65                  70                  75                  80
Glu Thr Gly Ile Leu Glu Ser Arg Arg Asp Pro Val Thr Leu Glu Asp 
                 85                  90                  95
Val Tyr Pro Ile His Met Ile Leu Glu Asn Lys Asp Gly Ile Gln Gly 
             100                105                110
Ser Cys Arg Tyr Phe Lys Glu Arg Lys Asp Ile Thr Ser Ser Ile Arg 
         115                120                125
Ser Lys Cys Leu Gln Pro Arg Cys Thr Met Val Glu Ala Phe Ser Arg 
     130                135                140
Trp Gly Lys Lys Leu Ile Ile Val Ala Ser Gln Asp Met Arg Tyr Arg 
 145                150                155                160
Ala Leu Ile Gly Leu Glu Gly Asp Pro Asp Leu Lys Leu Pro Asp Phe 
                 165                170                175
Ser Tyr Cys Ile Leu Glu Arg Leu Gly Arg Ser Arg Trp Gln Gly Glu 
             180                185                190
Leu Gln Arg Asp Leu His Thr Thr Ala Phe Lys Val Asp Ala Gly Lys 
         195                200                205
Leu His Tyr His Arg Lys Ile Leu Asn Lys Asn Gly Leu Ile Thr Met 
     210                215                220
Gln Ser His Val Ile Arg Leu Pro Thr Gly Ala Gln Gln His Ser Ile 
 225                230                235                240
Leu Leu Leu Leu Asn Arg Phe His Val Asp Arg Arg Ser Lys Tyr Asp 
                 245                250                255
Ile Leu Met Glu Lys Leu Ser Met Met Leu Ser Thr Arg Ser Asn Gln 
             260                265                270
Ile Glu Thr Leu Gly Lys Leu Arg Glu Glu Leu Gly Leu Cys Glu Arg 
         275                280                285
Thr Phe Lys Arg Leu Tyr Gln Tyr Met Leu Asn Ala Gly Leu Ala Lys 
     290                295                300
Val Val Ser Leu Pro Leu Gln Glu Ile His Pro Glu Cys Gly Pro Cys 
 305                310                315                320
Lys Thr Lys Lys Gly Thr Asp Val Met Val Arg Cys Leu Lys Leu Leu 
                 325                330                335
Lys Glu Phe Arg Arg Lys Met Glu Asp Asp His Asp Asp Asp Asp Asp 
             340                345                350
Glu Glu Ala Ile Ser Lys Ala Val Pro Pro Val Asp Ile Val Phe Glu 
         355                360                365
Arg Asp Met Leu Thr Gln Thr Tyr Glu Leu Ile Glu Arg Arg Gly Thr 
     370                375                380
Lys Gly Ile Ser Gln Ala Glu Ile Arg Val Ala Met Asn Val Gly Lys 
 385                390                395                400
Leu Glu Ala Arg Met Leu Cys Arg Leu Leu Gln Arg Phe Lys Val Val 
                 405                410                415
Lys Gly Phe Met Glu Asp Glu Gly Arg Gln Arg Thr Thr Lys Tyr Ile 
             420                425                430
Ser Cys Val Phe Ala Glu Glu Ser Asp Leu Ser Arg Gln Tyr Ala Arg 
         435                440                445
Glu Lys Ala Arg Gly Glu Leu Leu Thr Thr Val Ser Leu Ala Ser Val 
     450                455                460
Gln Asp Glu Ser Leu Met Pro Glu Gly Glu Glu Ala Phe Leu Ser Asp 
 465                470                475                480
Ser Glu Ser Glu Glu Glu Ser Ser Cys Ser Gly Lys Arg Arg Gly Arg 
                 485                490                495
Gly Ser Arg Gly His Ser Arg Ala Ser Gly Asp Ala Gly Pro Gly Ser 
             500                505                510
Arg Pro His His Ser Thr Pro Ala Lys Gly Gly Trp Lys Val Leu Asn 
         515                520                525
Leu His Pro Leu Lys Lys Pro Lys Ser Ala Ala Val Glu Arg Ser Arg 
     530                535                540
Arg Ser Ser Ala Cys Arg Asp Gly Leu Asp Thr Ser Ser Ser Ser Glu 
 545                550                555                560
Leu Asn Ile Pro Phe Asp Pro His Ser Met Asp Ser His Ser Gly Asp 
                 565                570                575
Ile Ala Val Ile Glu Glu Val Arg Leu Asp Asn Pro Lys Glu Gly Gly 
             580                585                590
Gly Ser Gln Lys Gly Gly Arg His Gly Ser Gly Gln Asp Lys Pro His 
         595                600                605
Lys Thr Tyr Arg Leu Leu Lys Arg Arg Asn Leu Ile Ile Glu Ala Val 
     610                615                620
Thr Asn Leu Arg Leu Ile Glu Ser Leu Phe Thr Ile Gln Lys Met Ile 
 625                630                635                640
Met Asp Gln Glu Lys Gln Glu Gly Val Ser Thr Lys Cys Cys Lys Lys 
                 645                650                655
Ser Ile Ile Arg Leu Val Arg Asn Leu Ser Glu Glu Gly Leu Leu Arg 
             660                665                670
Leu Tyr Arg Thr Thr Val Ile Gln Asp Gly Ile Lys Lys Lys Val Asp 
         675                680                685
Leu Val Val His Pro Ser Met Asp Gln Asn Asp Pro Leu Val Arg Ser 
     690                695                700
Ala Ile Glu Gln Val Arg Phe Arg Ile Ser Asn Ser Ser Thr Ala Asn 
 705                710                715                720
Arg Val Lys Val Pro Pro Ala Pro Ala Pro Gln Glu Glu Ala Glu Glu 
                 725                730                735
Gly Asn Gln Glu Pro Glu Val Pro Ser Arg Ser Ala Asp Ser Glu Ala 
             740                745                750
Asn Thr Ser Ser Lys Pro Glu Ser Thr Arg Val Lys Lys Thr Asp Glu 
         755                760                765
Lys Met Gly Ile Thr Pro Leu Lys Asn Tyr Lys Pro Val Ile Val Pro 
     770                775                780
Gly Leu Gly Arg Ser Ile Gly Phe Leu Pro Lys Met Pro Arg Leu Arg 
 785                790                795                800
Val Met His Leu Phe Leu Trp Tyr Leu Val Tyr Gly His Pro Ala Ser 
                 805                810                815
His Thr Gly Glu Gln Pro Thr Phe His Ser Glu Arg Lys Thr Gly Lys 
             820                825                830
Gln Glu Pro Ser Arg Pro Gly Val Gln Pro Ser Ser Gly Asp Asp Trp 
         835                840                845
Asp Ser Ser Glu Ala Lys Asn Ser Thr Glu Ser Ser Ser Trp Glu Ala 
     850                855                860
Glu Met Glu Leu Ser Thr Glu Arg Val Tyr Val Asp Glu Ile Ser Trp 
 865                870                875                880
Met Arg Tyr Val Pro Pro Ile Pro Ile His Arg Asp Phe Gly Phe Gly 
                 885                890                895
Trp Ala Leu Val Ser Asp Ile Leu Leu Cys Leu Pro Leu Ser Ile Phe 
             900                905                910
Val Gln Val Val Gln Val Ser Tyr Lys Val Asp Asn Leu Glu Asp Phe 
         915                920                925
Leu Asn Asp Pro Leu Lys Lys His Thr Leu Ile Arg Phe Leu Pro Arg 
     930                935                940
His Ile Arg Gln Gln Leu Leu Tyr Lys Arg Arg Tyr Ile Phe Ser Val 
 945                950                955                960
Val Glu Asn Leu Gln Arg Leu Cys Tyr Met Gly Leu Leu Gln Phe Gly 
                 965                970                975
Pro Thr Glu Lys Phe Gln Asp Lys Asp Gln Val Phe Val Phe Leu Lys 
             980                985                990
Lys Asn Ala Val Ile Val Asp Thr Thr Ile Cys Asp Pro His Tyr Asn 
         995                1000                1005
Leu Ala His Ser Ser Arg Pro Phe Glu Arg Arg Leu Tyr Val Leu Asp 
     1010                1015                1020
Ser Met Gln Asp Val Glu Ser Tyr Trp Phe Asp Leu Gln Cys Ile Cys 
 1025                1030                1035                1040
Leu Asn Thr Pro Leu Gly Val Val Arg Cys Pro Cys Ala Gln Lys Ile 
                 1045                1050                1055
Cys Pro Asp Pro Gly Ser Asp Pro Glu Gly Ser Leu Arg Lys Glu Gln 
             1060                1065                1070
Glu Ser Ala Met Asp Lys His Asn Leu Glu Arg Lys Cys Ala Met Leu 
         1075                1080                1085
Glu Tyr Thr Thr Gly Ser Arg Glu Val Val Asp Glu Gly Leu Val Pro 
     1090                1095                1100
Gly Asp Gly Leu Gly Ala Ala Gly Leu Asp Ser Ser Phe Tyr Ala His 
 1105                1110                1115                1120
Leu Lys Arg Asn Trp Val Trp Thr Ser Tyr Ile Ile Asn Lys Ala Arg 
                 1125                1130                1135
Lys Asn Asn Thr Ser Glu Asn Gly Leu Thr Gly Arg Leu Gln Thr Phe 
             1140                1145                1150
Leu Ser Lys Arg Pro Met Pro Leu Gly Ser Gly Gly Ser Gly Arg Leu 
         1155                1160                1165
Pro Leu Trp Ser Glu Gly Lys Ala Asp Ala Glu Leu Cys Ala Asp Lys 
     1170                1175                1180
Glu Glu His Phe Glu Leu Asp Arg Glu Pro Thr Pro Gly Arg Asn Arg 
 1185                1190                1195                1200
Lys Val Arg Gly Gly Lys Ser Gln Lys Arg Lys Arg Leu Lys Lys Glu 
                 1205                1210                1215
Pro Ile Arg Lys Thr Lys Arg Arg Arg Arg Gly Glu His Pro Glu Ala 
             1220                1225                1230
Lys Ser Lys Lys Leu Arg Tyr Gln Asp Glu Ala Asp Gln Asn Ala Leu 
         1235                1240                1245
Arg Met Met Thr Arg Leu Arg Val Ser Trp Ser Met Gln Glu Asp Gly 
     1250                1255                1260
Leu Leu Met Leu Cys Arg Ile Ala Ser Asn Val Leu Asn Thr Lys Val 
 1265                1270                1275                1280
Lys Gly Pro Phe Val Thr Trp Gln Val Val Arg Asp Ile Leu His Ala 
                 1285                1290                1295
Thr Phe Glu Glu Ser Leu Asp Lys Thr Ser His Ser Val Gly Arg Arg 
             1300                1305                1310
Ala Arg Tyr Ile Val Lys Asn Pro Gln Ala Phe Met Asn Tyr Lys Val 
         1315                1320                1325
Cys Leu Ala Glu Val Tyr Gln Asp Lys Ala Leu Val Gly Asp Phe Met 
     1330                1335                1340
Ser Arg Lys Asp Asn Tyr Glu Asp Pro Lys Val Cys Ala Lys Glu Phe 
 1345                1350                1355                1360
Lys Glu Phe Val Glu Lys Leu Lys Glu Lys Phe Ser Ser Gly Leu Arg 
                 1365                1370                1375
Asn Pro Asn Leu Glu Ile Pro Asp Thr Leu Gln Glu Leu Phe Ala Lys 
             1380                1385                1390
Tyr Arg Val Leu Ala Ile Gly Asp Glu Lys Asp Arg Val Arg Lys Glu 
         1395                1400                1405
Asp Glu Leu Asn Ser Val Glu Asp Ile His Phe Leu Val Leu Gln Asn 
     1410                1415                1420
Leu Ile Gln Ser Thr Leu Ser Leu Ser Asn Ser Gln Ser Asn Ser Cys 
 1425                1430                1435                1440
Gln Ser Phe Gln Ile Phe Arg Leu Tyr Arg Glu Phe Arg Glu Pro Val 
                 1445                1450                1455
Leu Val Arg Ala Phe Met Glu Cys Gln Lys Arg Ser Leu Val Asn Arg 
             1460                1465                1470
Arg Arg Val Ser His Ser Gln Gly Pro Lys Lys Asn Arg Ala Val Pro 
         1475                1480                1485
Phe Val Pro Met Ser Tyr Gln Leu Ser Gln Ser Tyr Tyr Lys Leu Phe 
     1490                1495                1500
Thr Trp Arg Phe Pro Thr Thr Val Cys Thr Glu Ser Phe Gln Phe Tyr 
 1505                1510                1515                1520
Asp Arg Leu Arg Ala Asn Gly Ile Leu Asp Gln Pro Asp His Phe Ser 
                 1525                1530                1535
Phe Lys Asp Met Asp Ser Asn Asp Pro Ser Ser Asp Leu Val Ala Phe 
             1540                1545                1550
Ser Leu Asp Ser Pro Gly Gly His Cys Val Thr Ala Leu Ala Leu Phe 
         1555                1560                1565
Ser Leu Gly Leu Leu Ser Val Asp Val Arg Ile Pro Glu Gln Ile Val 
     1570                1575                1580
Val Val Asp Ser Ser Met Val Glu Ser Glu Val Met Lys Ser Leu Gly 
 1585                1590                1595                1600
Lys Asp Gly Gly Leu Asp Asp Asp Asp Glu Glu Glu Asp Leu Asp Glu 
                 1605                1610                1615
Gly Ser Gly Thr Lys Arg Gln Ser Val Glu Val Lys Ala His Gln Ala 
             1620                1625                1630
Ser His Thr Lys Tyr Leu Leu Met Arg Gly Tyr Tyr Thr Val Pro Gly 
         1635                1640                1645
Met Val Ser Thr Arg Asn Leu Asn Pro Asn Asp Ser Ile Val Val Asn 
     1650                1655                1660
Ser Cys Gln Val Lys Phe Arg Leu Arg Asn Thr Pro Ala Pro Thr His 
 1665                1670                1675                1680
Leu Gly Pro Thr Gly Pro Thr Ala Thr Pro Leu Glu Glu Leu Gln Ala 
                 1685                1690                1695
Gly Pro Ser Cys Leu Pro Ala Ser Phe Thr Ser Leu Val Asp Pro Gln 
             1700                1705                1710
Leu His Thr Arg Cys Pro Glu Glu Phe Ala His Gln Met Ala Gln Ser 
         1715                1720                1725
Gly Tyr Ser Pro Glu Asp Val Ala Ala Ser Leu Glu Ile Leu Gln Ala 
     1730                1735                1740
Val Ala Ala Ala Asp Cys Phe Gly Val Asp Arg Glu Lys Leu Ser Arg 
 1745                1750                1755                1760
Gln Phe Ser Ala Leu Glu Lys Ile Ala Asp Lys Arg Thr Arg Thr Phe 
                 1765                1770                1775
Leu Asp Tyr Ile Gln Asp Leu Leu Glu Gln Gln Gln Val Met Glu Val 
             1780                1785                1790
Gly Gly Asn Thr Val Arg Leu Val Ala Met Ala Ser Ala Gln Pro Trp 
         1795                1800                1805
Leu Leu Pro Ser Val Arg Leu Lys Asp Val Glu Ile Asp Thr Lys Ala 
     1810                1815                1820
Ser Gly Asp Asp Ser Gln Ser Arg Leu Pro Ala Gly Ser Ser Ile Glu 
 1825                1830                1835                1840
Asp His Thr Ser Glu Gly Ala Pro Ile Pro Pro Val Ser Ser Asn Gly 
                 1845                1850                1855
Thr Lys Lys Arg Pro Tyr Cys Ser Ile Gln Ser Pro Glu Thr Asp Ala 
             1860                1865                1870
Glu Glu Ala Thr Arg Leu Pro Ala Lys Lys Pro Thr Leu Gln Asp Val 
         1875                1880                1885
Cys Val Ala Ala Ser Pro Arg Pro Gly Thr Glu Glu Gln Thr Glu Ala 
     1890                1895                1900
Gln Ala Gln Phe Ala Ala Pro Glu Asp Ala Gly Ala Glu Gly Pro Arg 
 1905                1910                1915                1920
Gln Glu Ser Gln Glu Ser Val Gly Val Ser Gly Leu Glu Gln Leu Gly 
                 1925                1930                1935
Cys Glu Phe Gln Leu Pro Glu Asn Ser Glu Asp Pro Arg Gly Leu Thr 
             1940                1945                1950
Glu Ser Asn Met Ala Gln Val Ala Trp Glu Ser Gly Cys Glu Arg Val 
         1955                1960                1965
Cys Phe Val Gly Arg Pro Trp Arg Gly Val Asp Gly Arg Leu Asn Met 
     1970                1975                1980
Pro Val Cys Lys Gly Met Met Glu Ala Val Leu Tyr His Ile Met Ser 
 1985                1990                1995                2000
Arg Pro Gly Val Pro Glu Ser Cys Leu Leu Gln Tyr Tyr Gln Gly Val 
                 2005                2010                2015
Leu Gln Pro Val Ala Val Leu Glu Leu Leu Arg Gly Leu Glu Ser Leu 
             2020                2025                2030
Gly Cys Ile Gln Lys Arg Met Leu Lys Lys Pro Ala Ser Val Ser Leu 
         2035                2040                2045
Phe Ser Arg Pro Val Val Glu Gly Leu Gly Gln Ala Ser Glu Ala Glu 
     2050                2055                2060
Ala Leu Ser Cys Gln Gly Ser Thr Val Thr Phe Tyr Glu Pro Thr Leu 
 2065                2070                2075                2080
Asp Cys Thr Ile Arg Leu Gly Arg Val Phe Pro His Asp Ile Asn Trp 
                 2085                2090                2095
Lys Gln Ser Gly Ser Ile Tyr Arg Cys Val Pro Gly Gln Gln Arg Ser 
             2100                2105                2110
Leu Cys Pro Cys Leu Ile Val Pro Pro Gly Leu Ser Gln Glu Pro Arg 
         2115                2120                2125
Pro Ser His Ser Cys Tyr Gln Ser Ser Ala Gln Pro Ser Thr Gly Val 
     2130                2135                2140
Ala Thr Ser Arg Ter 
 2145



<210> 3155
<211> 6996
<212> DNA
<213> Homo sapiens
<308> U02619
<400> 3155

atggaccaa  gcccttggc  gtgcgttgc  cacccccgg  gcgccgcga  tgaagtagc  60
atggacgcg  tggagtcgt  gttggacga  gtcgctctg  aggggctcg  tggcctgtg  120
ctgccagcg  tgtggagcc  gctggagac  cgagtgccg  ccttcccgc  gcctttgga  180
ccctgcacg  aggagtttc  ctggcgggc  ctcgccacg  acccgggca  cagcttcta  240
gaggagcct  gggagcgac  cgacctaca  ctccaggac  ggtatgaag  aattgattt  300
gaaactgga  ttttggagt  taggaggga  ccggtggct  tggaggatg  ctaccccat  360
catatgatc  tagagaata  ggatggcat  cagggctca  gccgctact  taaggagag  420
aaaaacatt  ccaatgaca  cagaaccaa  tccttgcag  ctcgctgta  aatggtgga  480
ccctttgac  ggtggggga  gaaactgat  atcggttcc  tcccagccc  tgcggtaca  540
gcccttgat  gcccaggag  gggatcccg  cctgaagct  cccgacttc  cctactgca  600
cctggaacg  ctaggccgg  ccaggtgca  ggggagctc  agcgagacc  tcacaccac  660
gctttcaag  ttgatgctg  gaagctgca  tatcacaga  aaattttga  caaaaacgg  720
ctgattaca  tgcagtccc  tgtgatccg  ttacccact  gagcccagc  acactcaat  780
ctcctccta  tgaaccggt  tcatgtgga  aggaggagc  aatacgaca  cctcatgga  840
aagctttcg  tcatgctga  cacacggac  aaccacata  agacgctgg  aaagctgag  900
gaagagctg  ggctgtgcg  aaggacgtt  aagcgtctg  accagtata  gctgaacgc  960
gggctagcc  aggtggtgt  tcttcgctt  caagagatc  accctgaat  tggaccttg  1020
aagacaaag  aagggaccg  cgtcatggt  cggtgcctc  agctgctga  ggaatttaa  1080
cggaatgac  atgatgatg  cgaggacga  gaggtcatc  ccaagacag  gcctccagt  1140
gacattgtg  tcgagcggg  tatgctcac  cagacctac  acctcattg  gcgcagagg  1200
acgaaagga  tttcccaag  tgaaatccg  gtggctatg  atgtgggaa  actagaagc  1260
agaatgctg  gccgacttc  tcaaagatt  aaagttgtc  agggattca  ggaagacga  1320
ggtcggcag  gaaccacca  gtacatttc  tgcgtgttt  cagaggaga  cgacctaag  1380
cggcagtac  aaagagaga  ggcccgcag  gagctcttg  ccaccgtga  cctggcgtc  1440
atgcaggag  agtcgcttc  gcctgaagg  gaggacacc  tcctctctg  gtcggacag  1500
gaggaggag  ggagcagca  caagcggag  ggcagaggg  cccagaaag  cacaagagc  1560
tctgcaaac  tccggccca  gacccagcc  catcactcc  ccccaacca  gggtgggtg  1620
aaagttgta  acctacacc  attgaaaaa  cagccgccc  ccttcccag  agctgctga  1680
gagagagcc  gccagagcc  tgccagcag  gacagcctc  tagatacca  cagcgtctc  1740
gaacccaac  tgtcctttg  ctcccactg  gcggacagc  acagtggtg  catagctgt  1800
atcgaggag  tccggatgg  aaacccaaa  gagagtagc  gttccctga  gactgggag  1860
cacagctca  gccaagaca  accacacga  acttaccga  tgctgaaac  caggaatct  1920
atcatagaa  ctgtcacca  tcttcgctt  atcgagagt  tattcacga  tcagaagat  1980
atcatggat  aggagaagc  ggaaggcgt  tccaccaag  gctgcaaga  gtccattgt  2040
cgcttggtg  ggaacctgt  tgaggaagg  ctcttgcga  tgtatcgga  cactgtcat  2100
caagatggc  tcaagaaga  ggtggatct  gtggtgcac  cgtccatgg  ccagaacga  2160
cctctagtg  gaagtgcca  cgagcaggt  cgcttccgg  tctccaatt  aagcacagc  2220
aacagggtt  aaacttccc  gcctccagt  ccccaaggg  aggcagaag  agacagtca  2280
ggaaaagag  gcccaagtg  atcagggga  tctcagctg  gtgcttcct  tagatcaga  2340
agtggacgg  tgaaaaaaa  tgataataa  atgggcata  ccccgctta  aaattatca  2400
cccattgta  ttcccggac  ggggcgttc  ctaggattt  tgcccaaaa  gcctcgcct  2460
cgggtggtc  acatgtttc  gtggtacct  atctacggg  accctgcca  caacaccgt  2520
gagaagcca  gcttcatca  tgaacggag  acgataaag  aggagtcag  cagggcagg  2580
gtccggccg  cctcctctg  aagtgcctg  gaggcctgc  ctgaagccc  atctaaagg  2640
agccaagat  gtgtcacct  ggaggctga  gtggagctt  ccacggaga  agtgtatgt  2700
gacgatgcc  cgtggatgc  ctacatccc  ccaatccca  tccacaggg  cttcggctt  2760
ggctgggct  tcgtcagcg  catcctcct  tgccttccc  tctccatct  catccagat  2820
gtgcaagtc  gctacaagg  ggacaacct  gaggaattt  tgaacgacc  gctgaagaa  2880
cacacgctg  tccgctttc  ccccaggcc  attcggcag  agcttctgt  caagaggcg  2940
tacattttt  cggtggtgg  gaaccttca  aggctgtgc  acatggggg  gctacagtt  3000
ggtcccacg  aaaagtttc  ggataaaga  caggtcttt  tcttcttga  gaagaatgc  3060
gtcattgtt  acactacca  ctgcgaccc  cattacaac  tgggccgca  gaggcggcc  3120
ttcgagagg  gcctctatg  cctgaactc  atgcaggat  tggaaaact  ctggtttga  3180
ctgcagtgc  tctgcctca  caccccact  ggcgtggtg  gctgcccgc  cgtcaggaa  3240
aacagcagc  cagaccagg  cagcgacga  gagggcagc  tgcagaagg  gcaggagag  3300
gccatggac  agcacaacc  ggagcgcaa  tgcgccatg  tggagtaca  cactggaag  3360
cgtgaggtg  tggatgaag  cttgatccc  ggagatggg  tgggtgccg  agggctcga  3420
tccagcttc  acggacacc  caagcgcaa  tggatctgg  ccagctaca  catcaacca  3480
gccaaaaag  agaacactg  cgcagagaa  ggactcaca  tgaggctcc  gacatttct  3540
tccaagcgc  caatgcccc  cagtgccag  ggcaacagc  ggttgaata  ttgggggga  3600
gcaagagta  gctccgagc  ctgtgctgg  tgggaagag  agtttgagg  ggaccgaga  3660
ccctcgctg  accgaaacc  gagagtgag  ggtgggaaa  gccagaagc  gaagcggct  3720
aagaaggac  ctgggaaga  gatcaagag  aagaagaaa  gagagttcc  aggagaaaa  3780
agcaaaagg  tgcgctacc  tgatgaagc  gaccagagt  ccctgcatc  gatgacgcg  3840
cttcgtgtc  cctggtcta  gcaggagga  gggctgctt  tgctgtgcc  cattgccag  3900
aatgtcctc  acaccaagg  gaagggtcc  tttgtcacc  ggcaggtgg  acgggacat  3960
ttgcatgcc  cgtttgaag  gtctttgga  aaaacatct  attcccttg  acgaagagc  4020
cgctacata  tcaaaaacc  acaggccta  ctcaactat  aagtgtgcc  ggccgaggt  4080
taccaggat  aagcacttg  tggagattt  atgaatcga  gaggtgact  tgatgaccc  4140
aaggtttgt  ccaacgagt  taaagaatt  gtggagaag  ttaaagaaa  gttcagttc  4200
gccctaagg  attctaacc  tgaaatccc  gacacactc  aggagctgt  cgccaggta  4260
cgagttttg  caattgggg  tgaaaaaga  caaaccagg  aagaggatg  acttaacag  4320
gtggatgac  tccactttc  ggtgcttca  aacctgatc  agagcacgc  ggccctctc  4380
gacagtcag  tgaagtcct  ccagtcatt  cagactttc  gcctctatc  ggagtacaa  4440
gaccacgtt  ttgtgaagg  cttcatgga  tgccagaag  ggagcttgg  caaccggcg  4500
cgggtcaac  acacgctgg  ccccaagaa  aaccgggcc  tccccttcg  gccaatgtc  4560
taccagcta  cccagacct  ctacaggat  tttacgtgg  gatttccaa  caccatctg  4620
acggagtca  tccagtttt  ggacagaat  cgggctgcc  gcaagttgg  ccagcctga  4680
cgtttctct  tcaaagacc  ggataataa  gagcccaca  acgacatgg  ggccttttc  4740
ctggacggc  ctggaggaa  ttgtgtggc  gtcctgacc  tcttctctc  gggcctcat  4800
tctgtggat  tcaggatcc  ggagcagat  atcgtggta  acagctcaa  ggtggagaa  4860
gaggtcatc  aaagcttgg  gaaggacgg  agcctggag  atgacgagg  tgaagagga  4920
gacttggac  aaggtgtag  gggcaagcg  cggagcatg  aggtgaaac  tgcgcaagc  4980
tcccacacc  actacctgc  gatgagggg  tactactcc  ccggcatcg  cagcacccg  5040
aacctcaac  ccaacgaca  cattgtggt  aactcctgc  agatgaagt  ccagctccg  5100
tgcacccct  tgcccgccc  gctcaggcc  gctgccgct  ctctggaag  gctaacaat  5160
ggaacctcc  gcctccctg  tacgttcac  aagctgata  acccccagg  aaacacctg  5220
agcttggag  agtttgtcc  ccagctgga  ctgtctggg  atagtcccg  agacctgac  5280
gctgccttg  agatcttgg  agccattat  gccacgggt  gttttggga  tgacaagga  5340
gagctgcgc  gacggttct  ggccttgga  aaggcaggt  gtgggcgca  caggacatt  5400
gcagattgc  tccaggccc  cctggagca  catcaggtg  tggaggtcg  tggcaacac  5460
gcgcgcctg  tagccatgg  ctctgcctg  ccttggctc  tgcactccg  gcggctgaa  5520
gacagagaa  acgccgaca  ccagagaga  gacccccag  ccagacccc  ggaggggtc  5580
tccagtgag  acagccccc  cgaggggca  gcacctcct  ctcacagcc  ccggggcac  5640
aagaggcgc  ccagctggg  cagtgagaa  ggggagacc  acgccgagg  cacccagat  5700
acccctgcc  agaggccag  gctccagga  tcaaatttg  cccccagcc  tgggcccgg  5760
gctgaagat  gggcagaag  ccaggcccc  tctccaccc  cagctcttg  agacaccgc  5820
gcagcggga  cagcacagg  agaccaaga  ggtgtcggt  agttcagtt  cccaggcca  5880
gagcagctg  gcggccagg  gcagcctcc  gagggctct  aagacccca  agggttcac  5940
gagagtttc  gagctgcca  catctccca  gcagcacgg  aaagggact  tgagagtgt  6000
tgcttcatc  gccggccgt  gcgtgtcgt  gatggccac  tgaaccttc  tgtatgcaa  6060
ggtatgatg  aggccatgc  gtaccacat  atgaccagg  ctggcatcc  cgagagctc  6120
ctgctgcgc  actaccagg  ggtcctgca  cccgtcgcc  tgctggagt  gctccaggg  6180
ctggagtcc  tcggctgca  ccggaagcg  tggctgaga  agccaaggc  tgtctcgct  6240
ttctctaca  ccgtggtgg  agaggtgga  gtgccctcc  gcctggacg  gagccccat  6300
gctttctat  agcccacct  ggactgtac  ctccggctg  gccgtgtgt  cccccacga  6360
gtcaactgg  acaagtgga  ccacctcta  gacccctgt  ggcgtcccc  ccctcccag  6420
caccgcctg  cacaccact  ctgcctggt  ctcggcaga  cccactgtg  cctggcctt  6480
ggtctgccg  gcctcctgc  gcaggggac  ggtgctttg  ccagagtca  agactgaca  6540
gtttcccac  gtactggaa  tctggaaag  ggggctccc  gacctgccc  tcccccagg  6600
tcttctggg  cttcccctt  ggaactggc  tcatcacac  gggagttgg  gcttcttgt  6660
tctgggtct  cagagtttg  cccgcctgt  cacacctca  attccagac  ctagccatc  6720
cggcaggat  tcctggctc  ttgagtgcc  aggtgccac  aagaggaag  gccttgtgg  6780
atacacctt  cagaatagg  atcggtgtg  cccgctgcg  ggggccccc  atgggggct  6840
tggcccctc  gcaggcagg  catcccaac  cctggctgg  actgaacca  ccagagcgg  6900
gcggctccc  tttcagcct  gtgagtcac  tggcaggcc  cagctgggc  ggctgtccg  6960
gtccctcag  ctggctggt  attccttgc  ggaggg  6996



<210> 3156
<211> 2110
<212> PRT
<213> Homo sapiens
<308> U02619
<400> 3156

Met Asp Ala Leu Glu Ser Leu Leu Asp Glu Val Ala Leu Glu Gly Leu 
  1               5                  10                  15
Asp Gly Leu Cys Leu Pro Ala Leu Trp Ser Arg Leu Glu Thr Arg Val 
             20                  25                  30
Pro Pro Phe Pro Leu Pro Leu Glu Pro Cys Thr Gln Glu Phe Leu Trp 
         35                  40                  45
Arg Ala Leu Ala Thr His Pro Gly Ile Ser Phe Tyr Glu Glu Pro Arg 
     50                  55                  60
Glu Arg Pro Asp Leu Gln Leu Gln Asp Arg Tyr Glu Glu Ile Asp Leu 
 65                  70                  75                  80
Glu Thr Gly Ile Leu Glu Ser Arg Arg Asp Pro Val Ala Leu Glu Asp 
                 85                  90                  95
Val Tyr Pro Ile His Met Ile Leu Glu Asn Lys Asp Gly Ile Gln Gly 
             100                105                110
Ser Cys Arg Tyr Phe Lys Glu Arg Lys Asn Ile Thr Asn Asp Ile Arg 
         115                120                125
Thr Lys Ser Leu Gln Pro Arg Cys Thr Met Val Glu Pro Phe Asp Arg 
     130                135                140
Trp Gly Lys Lys Leu Ile Ile Gly Ser Leu Pro Ala His Ala Val Gln 
 145                150                155                160
Ala Leu Asp Ser Pro Gly Gly Gly Ser Arg Pro Glu Ala Ala Arg Leu 
                 165                170                175
Leu Leu Leu His Pro Gly Thr Ala Arg Pro Val Gln Val Gln Gly Glu 
             180                185                190
Leu Gln Arg Asp Leu His Thr Thr Ala Phe Lys Val Asp Ala Gly Lys 
         195                200                205
Leu His Tyr His Arg Lys Ile Leu Asn Lys Asn Gly Leu Ile Thr Met 
     210                215                220
Gln Ser His Val Ile Arg Leu Pro Thr Gly Ala Gln Gln His Ser Ile 
 225                230                235                240
Leu Leu Leu Leu Asn Arg Phe His Val Asp Arg Arg Ser Lys Tyr Asp 
                 245                250                255
Ile Leu Met Glu Lys Leu Ser Val Met Leu Ser Thr Arg Thr Asn His 
             260                265                270
Ile Glu Thr Leu Gly Lys Leu Arg Glu Glu Leu Gly Leu Cys Glu Arg 
         275                280                285
Thr Phe Lys Arg Leu Tyr Gln Tyr Met Leu Asn Ala Gly Leu Ala Lys 
     290                295                300
Val Val Ser Leu Arg Leu Gln Glu Ile His Pro Glu Cys Gly Pro Cys 
 305                310                315                320
Lys Thr Lys Lys Gly Thr Asp Val Met Val Arg Cys Leu Lys Leu Leu 
                 325                330                335
Lys Glu Phe Lys Arg Asn Asp His Asp Asp Asp Glu Asp Glu Glu Val 
             340                345                350
Ile Ser Lys Thr Val Pro Pro Val Asp Ile Val Phe Glu Arg Asp Met 
         355                360                365
Leu Thr Gln Thr Tyr Asp Leu Ile Glu Arg Arg Gly Thr Lys Gly Ile 
     370                375                380
Ser Gln Ala Glu Ile Arg Val Ala Met Asn Val Gly Lys Leu Glu Ala 
 385                390                395                400
Arg Met Leu Cys Arg Leu Leu Gln Arg Phe Lys Val Val Lys Gly Phe 
                 405                410                415
Met Glu Asp Glu Gly Arg Gln Arg Thr Thr Lys Tyr Ile Ser Cys Val 
             420                425                430
Phe Ala Glu Glu Ser Asp Leu Ser Arg Gln Tyr Gln Arg Glu Lys Ala 
         435                440                445
Arg Ser Glu Leu Leu Thr Thr Val Ser Leu Ala Ser Met Gln Glu Glu 
     450                455                460
Ser Leu Leu Pro Glu Gly Glu Asp Thr Phe Leu Ser Glu Ser Asp Ser 
 465                470                475                480
Glu Glu Glu Arg Ser Ser Ser Lys Arg Arg Gly Arg Gly Ser Gln Lys 
                 485                490                495
Asp Thr Arg Ala Ser Ala Asn Leu Arg Pro Lys Thr Gln Pro His His 
             500                505                510
Ser Thr Pro Thr Lys Gly Gly Trp Lys Val Val Asn Leu His Pro Leu 
         515                520                525
Lys Lys Gln Pro Pro Ser Phe Pro Gly Ala Ala Glu Glu Arg Ala Cys 
     530                535                540
Gln Ser Leu Ala Ser Arg Asp Ser Leu Leu Asp Thr Ser Ser Val Ser 
 545                550                555                560
Glu Pro Asn Val Ser Phe Val Ser His Cys Ala Asp Ser Asn Ser Gly 
                 565                570                575
Asp Ile Ala Val Ile Glu Glu Val Arg Met Glu Asn Pro Lys Glu Ser 
             580                585                590
Ser Ser Ser Leu Lys Thr Gly Arg His Ser Ser Gly Gln Asp Lys Pro 
         595                600                605
His Glu Thr Tyr Arg Leu Leu Lys Arg Arg Asn Leu Ile Ile Glu Ala 
     610                615                620
Val Thr Asn Leu Arg Leu Ile Glu Ser Leu Phe Thr Ile Gln Lys Met 
 625                630                635                640
Ile Met Asp Gln Glu Lys Gln Glu Gly Val Ser Thr Lys Cys Cys Lys 
                 645                650                655
Lys Ser Ile Val Arg Leu Val Arg Asn Leu Ser Glu Glu Gly Leu Leu 
             660                665                670
Arg Leu Tyr Arg Thr Thr Val Ile Gln Asp Gly Ile Lys Lys Lys Val 
         675                680                685
Asp Leu Val Val His Pro Ser Met Asp Gln Asn Asp Pro Leu Val Arg 
     690                695                700
Ser Ala Ile Glu Gln Val Arg Phe Arg Ile Ser Asn Ser Ser Thr Ala 
 705                710                715                720
Asn Arg Val Lys Thr Ser Gln Pro Pro Val Pro Gln Gly Glu Ala Glu 
                 725                730                735
Glu Asp Ser Gln Gly Lys Glu Gly Pro Ser Gly Ser Gly Asp Ser Gln 
             740                745                750
Leu Ser Ala Ser Ser Arg Ser Glu Ser Gly Arg Met Lys Lys Ser Asp 
         755                760                765
Asn Lys Met Gly Ile Thr Pro Leu Arg Asn Tyr His Pro Ile Val Val 
     770                775                780
Pro Gly Leu Gly Arg Ser Leu Gly Phe Leu Pro Lys Met Pro Arg Leu 
 785                790                795                800
Arg Val Val His Met Phe Leu Trp Tyr Leu Ile Tyr Gly His Pro Ala 
                 805                810                815
Ser Asn Thr Val Glu Lys Pro Ser Phe Ile Ser Glu Arg Arg Thr Ile 
             820                825                830
Lys Gln Glu Ser Gly Arg Ala Gly Val Arg Pro Ser Ser Ser Gly Ser 
         835                840                845
Ala Trp Glu Ala Cys Ser Glu Ala Pro Ser Lys Gly Ser Gln Asp Gly 
     850                855                860
Val Thr Trp Glu Ala Glu Val Glu Leu Ala Thr Glu Thr Val Tyr Val 
 865                870                875                880
Asp Asp Ala Ser Trp Met Arg Tyr Ile Pro Pro Ile Pro Val His Arg 
                 885                890                895
Asp Phe Gly Phe Gly Trp Ala Leu Val Ser Asp Ile Leu Leu Cys Leu 
             900                905                910
Pro Leu Ser Ile Phe Ile Gln Ile Val Gln Val Ser Tyr Lys Val Asp 
         915                920                925
Asn Leu Glu Glu Phe Leu Asn Asp Pro Leu Lys Lys His Thr Leu Ile 
     930                935                940
Arg Phe Leu Pro Arg Pro Ile Arg Gln Gln Leu Leu Tyr Lys Arg Arg 
 945                950                955                960
Tyr Ile Phe Ser Val Val Glu Asn Leu Gln Arg Leu Cys Tyr Met Gly 
                 965                970                975
Val Leu Gln Phe Gly Pro Thr Glu Lys Phe Gln Asp Lys Asp Gln Val 
             980                985                990
Phe Ile Phe Leu Lys Lys Asn Ala Val Ile Val Asp Thr Thr Ile Cys 
         995                1000                1005
Asp Pro His Tyr Asn Leu Gly Arg Arg Arg Arg Pro Phe Glu Arg Arg 
     1010                1015                1020
Leu Tyr Val Leu Asn Ser Met Gln Asp Val Glu Asn Tyr Trp Phe Asp 
 1025                1030                1035                1040
Leu Gln Cys Val Cys Leu Asn Thr Pro Leu Gly Val Val Arg Cys Pro 
                 1045                1050                1055
Arg Val Arg Lys Asn Ser Ser Thr Asp Gln Gly Ser Asp Glu Glu Gly 
             1060                1065                1070
Ser Leu Gln Lys Glu Gln Glu Ser Ala Met Asp Lys His Asn Leu Glu 
         1075                1080                1085
Arg Lys Cys Ala Met Leu Glu Tyr Thr Thr Gly Ser Arg Glu Val Val 
     1090                1095                1100
Asp Glu Gly Leu Ile Pro Gly Asp Gly Leu Gly Ala Ala Gly Leu Asp 
 1105                1110                1115                1120
Ser Ser Phe Tyr Gly His Leu Lys Arg Asn Trp Ile Trp Thr Ser Tyr 
                 1125                1130                1135
Ile Ile Asn Gln Ala Lys Lys Glu Asn Thr Ala Ala Glu Asn Gly Leu 
             1140                1145                1150
Thr Val Arg Leu Gln Thr Phe Leu Ser Lys Arg Pro Met Pro Leu Ser 
         1155                1160                1165
Ala Arg Gly Asn Ser Arg Leu Asn Ile Trp Gly Glu Ala Arg Val Gly 
     1170                1175                1180
Ser Glu Leu Cys Ala Gly Trp Glu Glu Gln Phe Glu Val Asp Arg Glu 
 1185                1190                1195                1200
Pro Ser Leu Asp Arg Asn Arg Arg Val Arg Gly Gly Lys Ser Gln Lys 
                 1205                1210                1215
Arg Lys Arg Leu Lys Lys Asp Pro Gly Lys Lys Ile Lys Arg Lys Lys 
             1220                1225                1230
Lys Gly Glu Phe Pro Gly Glu Lys Ser Lys Arg Leu Arg Tyr His Asp 
         1235                1240                1245
Glu Ala Asp Gln Ser Ala Leu His Arg Met Thr Arg Leu Arg Val Thr 
     1250                1255                1260
Trp Ser Met Gln Glu Asp Gly Leu Leu Val Leu Cys Arg Ile Ala Ser 
 1265                1270                1275                1280
Asn Val Leu Asn Thr Lys Val Lys Gly Pro Phe Val Thr Trp Gln Val 
                 1285                1290                1295
Val Arg Asp Ile Leu His Ala Thr Phe Glu Glu Ser Leu Asp Lys Thr 
             1300                1305                1310
Ser His Ser Leu Gly Arg Arg Ala Arg Tyr Ile Val Lys Asn Pro Gln 
         1315                1320                1325
Ala Tyr Leu Asn Tyr Lys Val Cys Leu Ala Glu Val Tyr Gln Asp Lys 
     1330                1335                1340
Ala Leu Val Gly Asp Phe Met Asn Arg Arg Gly Asp Tyr Asp Asp Pro 
 1345                1350                1355                1360
Lys Val Cys Ala Asn Glu Phe Lys Glu Phe Val Glu Lys Leu Lys Glu 
                 1365                1370                1375
Lys Phe Ser Ser Ala Leu Arg Asn Ser Asn Leu Glu Ile Pro Asp Thr 
             1380                1385                1390
Leu Gln Glu Leu Phe Ala Arg Tyr Arg Val Leu Ala Ile Gly Asp Glu 
         1395                1400                1405
Lys Asp Gln Thr Arg Lys Glu Asp Glu Leu Asn Ser Val Asp Asp Ile 
     1410                1415                1420
His Phe Leu Val Leu Gln Asn Leu Ile Gln Ser Thr Leu Ala Leu Ser 
 1425                1430                1435                1440
Asp Ser Gln Met Lys Ser Tyr Gln Ser Phe Gln Thr Phe Arg Leu Tyr 
                 1445                1450                1455
Arg Glu Tyr Lys Asp His Val Leu Val Lys Ala Phe Met Glu Cys Gln 
             1460                1465                1470
Lys Arg Ser Leu Val Asn Arg Arg Arg Val Asn His Thr Leu Gly Pro 
         1475                1480                1485
Lys Lys Asn Arg Ala Leu Pro Phe Val Pro Met Ser Tyr Gln Leu Ser 
     1490                1495                1500
Gln Thr Tyr Tyr Arg Ile Phe Thr Trp Arg Phe Pro Ser Thr Ile Cys 
 1505                1510                1515                1520
Thr Glu Ser Phe Gln Phe Leu Asp Arg Met Arg Ala Ala Gly Lys Leu 
                 1525                1530                1535
Asp Gln Pro Asp Arg Phe Ser Phe Lys Asp Gln Asp Asn Asn Glu Pro 
             1540                1545                1550
Thr Asn Asp Met Val Ala Phe Ser Leu Asp Gly Pro Gly Gly Asn Cys 
         1555                1560                1565
Val Ala Val Leu Thr Leu Phe Ser Leu Gly Leu Ile Ser Val Asp Val 
     1570                1575                1580
Arg Ile Pro Glu Gln Ile Ile Val Val Asp Ser Ser Met Val Glu Asn 
 1585                1590                1595                1600
Glu Val Ile Lys Ser Leu Gly Lys Asp Gly Ser Leu Glu Asp Asp Glu 
                 1605                1610                1615
Asp Glu Glu Asp Asp Leu Asp Glu Gly Val Gly Gly Lys Arg Arg Ser 
             1620                1625                1630
Met Glu Val Lys Pro Ala Gln Ala Ser His Thr Asn Tyr Leu Leu Met 
         1635                1640                1645
Arg Gly Tyr Tyr Ser Pro Gly Ile Val Ser Thr Arg Asn Leu Asn Pro 
     1650                1655                1660
Asn Asp Ser Ile Val Val Asn Ser Cys Gln Met Lys Phe Gln Leu Arg 
 1665                1670                1675                1680
Cys Thr Pro Val Pro Ala Arg Leu Arg Pro Ala Ala Ala Pro Leu Glu 
                 1685                1690                1695
Glu Leu Thr Met Gly Thr Ser Cys Leu Pro Asp Thr Phe Thr Lys Leu 
             1700                1705                1710
Ile Asn Pro Gln Glu Asn Thr Cys Ser Leu Glu Glu Phe Val Leu Gln 
         1715                1720                1725
Leu Glu Leu Ser Gly Tyr Ser Pro Glu Asp Leu Thr Ala Ala Leu Glu 
     1730                1735                1740
Ile Leu Glu Ala Ile Ile Ala Thr Gly Cys Phe Gly Ile Asp Lys Glu 
 1745                1750                1755                1760
Glu Leu Arg Arg Arg Phe Ser Ala Leu Glu Lys Ala Gly Gly Gly Arg 
                 1765                1770                1775
Thr Arg Thr Phe Ala Asp Cys Ile Gln Ala Leu Leu Glu Gln His Gln 
             1780                1785                1790
Val Leu Glu Val Gly Gly Asn Thr Ala Arg Leu Val Ala Met Gly Ser 
         1795                1800                1805
Ala Trp Pro Trp Leu Leu His Ser Val Arg Leu Lys Asp Arg Glu Asp 
     1810                1815                1820
Ala Asp Ile Gln Arg Glu Asp Pro Gln Ala Arg Pro Leu Glu Gly Ser 
 1825                1830                1835                1840
Ser Ser Glu Asp Ser Pro Pro Glu Gly Gln Ala Pro Pro Ser His Ser 
                 1845                1850                1855
Pro Arg Gly Thr Lys Arg Arg Ala Ser Trp Ala Ser Glu Asn Gly Glu 
             1860                1865                1870
Thr Asp Ala Glu Gly Thr Gln Met Thr Pro Ala Lys Arg Pro Ala Leu 
         1875                1880                1885
Gln Asp Ser Asn Leu Ala Pro Ser Leu Gly Pro Gly Ala Glu Asp Gly 
     1890                1895                1900
Ala Glu Ala Gln Ala Pro Ser Pro Pro Pro Ala Leu Glu Asp Thr Ala 
 1905                1910                1915                1920
Ala Ala Gly Ala Ala Gln Glu Asp Gln Glu Gly Val Gly Glu Phe Ser 
                 1925                1930                1935
Ser Pro Gly Gln Glu Gln Leu Ser Gly Gln Ala Gln Pro Pro Glu Gly 
             1940                1945                1950
Ser Glu Asp Pro Arg Gly Phe Thr Glu Ser Phe Gly Ala Ala Asn Ile 
         1955                1960                1965
Ser Gln Ala Ala Arg Glu Arg Asp Cys Glu Ser Val Cys Phe Ile Gly 
     1970                1975                1980
Arg Pro Trp Arg Val Val Asp Gly His Leu Asn Leu Pro Val Cys Lys 
 1985                1990                1995                2000
Gly Met Met Glu Ala Met Leu Tyr His Ile Met Thr Arg Pro Gly Ile 
                 2005                2010                2015
Pro Glu Ser Ser Leu Leu Arg His Tyr Gln Gly Val Leu Gln Pro Val 
             2020                2025                2030
Ala Val Leu Glu Leu Leu Gln Gly Leu Glu Ser Leu Gly Cys Ile Arg 
         2035                2040                2045
Lys Arg Trp Leu Arg Lys Pro Arg Pro Val Ser Leu Phe Ser Thr Pro 
     2050                2055                2060
Val Val Glu Glu Val Glu Val Pro Ser Ser Leu Asp Glu Ser Pro Met 
 2065                2070                2075                2080
Ala Phe Tyr Glu Pro Thr Leu Asp Cys Thr Leu Arg Leu Gly Arg Val 
                 2085                2090                2095
Phe Pro His Glu Val Asn Trp Asn Lys Trp Ile His Leu Ter 
             2100                2105                2110



<210> 3157
<211> 6878
<212> DNA
<213> Rattus norvegicus
<308> L28801
<400> 3157

gccggggct  ctaactgaa  aggccatgg  cgcgctcga  tcgttgttg  acgaggtgg  60
cctggaggg  ctcgacggc  tgtgcctgc  cgcgctgtg  agccgcctg  aatcccgct  120
gcctgcctt  cctttgccg  tggaaccct  cacgcagga  tttctgtgg  gggccttag  180
cacgcaccc  ggcatcagt  tctacgagg  gccgcgaga  cgacctgac  tgcagctcc  240
agaccgata  gaagaaatc  acttggaaa  tggaatttt  gagtccagg  gggacccag  300
cactctgga  gatgtctac  ccattcata  gatcttaga  aataaggat  gcatccagg  360
ctcctgccg  tactttaag  agagaaagg  catcaccag  agcatcagg  gcaagtgtt  420
gcagcctcg  tgtacaatg  tagaagcct  cagcaggtg  ggtaagaag  tcatcattg  480
ggcttccca  gacatgcga  accgggcct  gataggcct  gagggggat  ctgatctga  540
gcttcctga  ttctcctac  gcattttgg  gcggttagg  cgatcgaga  ggcaagggg  600
gctgcaacg  gaccttcac  ccaccgctt  caaggtcga  gctgggaag  ttcattatc  660
caggaaaat  ttgaacaag  atgggctca  tacaatgca  tcacacgtg  tccgactgc  720
tactggagc  cagcaacac  ccatcctcc  cctccttaa  cggtttcat  tagacagga  780
gagcaagta  gacatcctc  tggagaagc  gtctatgat  ctgagcaca  ggagcaacc  840
gatcgagac  ctgggcaag  tgagggagg  gctgggact  tgtgaaagg  cgttcaagc  900
tctgtacca  tacatgctg  atgctgggc  ggccaaagt  gtgtccctt  ccttgcagg  960
gattcaccc  gagtgtggt  cctgtaaga  caagaaagg  actgatgtc  tggttcggt  1020
ccttaagct  ctgaaggag  tcaggcgaa  gatggaaga  gaccatgac  acgatgacg  1080
tgaagaggc  atctccaag  ctgtacctc  cgtggacat  gtgtttgag  gggacatgc  1140
cacgcagac  tacgagctc  ttgagcgca  aggaacgaa  ggaatttcc  aagctgaga  1200
ccgagttgc  atgaatgtg  gaaaactgg  agcaagaat  ctgtgtcgg  tccttcaga  1260
gttcaaggt  gtcaaggga  tcatggaag  tgaaggccg  cagaggacc  ccaagtaca  1320
ttcctgtgt  tttgcggag  agagtgact  gagccgcca  tatgcgcgt  aaaaggccc  1380
aggagagct  ctaaccact  tgagcctcg  ctcagtgca  gatgaatcc  tcatgcctg  1440
gggtgaaga  gccttcctc  ctgactccg  aagtgagga  gagagcagc  gcagtggca  1500
gcgtagggg  cgagggtcc  gggggcatt  aagagcctc  ggggatgct  ggcctggct  1560
tcggcctca  cactccact  cagccaagg  cgggtggaa  gtcctaaat  tgcacccat  1620
aaagaagcc  aaaagtgcc  ctgtggaaa  atcccgccg  agctctgct  gtagggatg  1680
cctggacac  agcagctca  ccgagctca  tataccctt  gaccctcac  gcatggaca  1740
tcacagtgg  gacatcgct  tgattgagg  ggtccggct  gataacccc  aggagggtg  1800
tggctccca  aagggcgga  ggcatggct  aggccagga  aagcctcac  aaacatacc  1860
actgctaaa  cgcagaaat  tgattatag  agctgtcac  aacctccgc  tgattgaga  1920
cctgttcac  attcagaag  tgatcatgg  ccaggagaa  caagagggt  tctccacca  1980
atgctgtaa  aagtccatt  tccgcttgg  gcggaacct  tctgaggag  gtctcttga  2040
attgtatag  actacagtc  ttcaagatg  catcaagaa  aaggtagac  tggtcgtgc  2100
cccttccat  gaccagaat  accctcttg  gagaagtgc  attgagcag  ttcgcttcc  2160
gatctccaa  tcaagcaca  caaacaggg  taaagttcc  ccggcccca  caccccaag  2220
ggaagcaga  gagggaaac  aagaaccag  ggtcccaag  agatcagca  actctgaag  2280
gaacacatc  tcgaagcca  aaagcacac  ggtgaaaaa  acagatgag  aaatgggca  2340
aaccccact  aagaattac  aacctgtca  agttcctgg  cttgggcgc  ccatagggt  2400
ccttcccaa  atgccacgc  ttcgggtga  gcacctgtt  ctgtggtac  tggtgtatg  2460
gcatcctgc  agccacact  gggaacagc  tactttcca  agtgagagg  aaacaggca  2520
gcaggagcc  agcagacca  gggtccagc  ctcctcagg  gatgactgg  actcctctg  2580
agccaaaaa  agcacagaa  gcagctcct  ggaggcaga  atggaactc  ccacagaga  2640
agtgtatgt  gatgagatc  catggatgc  ctacgtccc  cccatcccc  tccacagag  2700
cttcggctt  ggctgggct  ttgtcagtg  cattcttct  tgccttccc  tctccatct  2760
tgtccaagt  gttcaagtc  gctacaagg  ggataacct  gaggatttt  tgaatgacc  2820
tctgaagaa  cacacactg  tccgcttcc  ccctaggca  atccggcag  agctactgt  2880
taagaggcg  tatattttc  cggtggtgg  gaacctgca  cggctgtgc  acatggggc  2940
gctacagtt  ggacccaca  agaagtttc  ggataaaga  caggtcttt  ttttcctga  3000
gaagaatgc  gtcattgtg  acaccacca  ctgtgaccc  cattacaac  tggcccaca  3060
cagccggcc  tttgagaga  gtctctacg  cttggattc  atgcaggat  tggaaagct  3120
ctggtttga  ctgcagtgt  tctgcctaa  caccccact  ggtgtggtg  gttgtccat  3180
tgcacagaa  atctgccct  atccgggca  tgacccaga  ggcagcttg  ggaaggagc  3240
agagagcgc  atggacaag  acaacctag  gcgcaagtg  gccatgctg  agtatacca  3300
ggggagccg  gaagttgtg  atgaaggct  agtccctgg  gatggactg  gagctgctg  3360
gctggactc  agcttctat  cacacctga  gcgcaactg  gtctggacc  gctatatca  3420
caacaaagc  agaaagaac  acacctccg  aaatgggct  acaggaaga  tccagactt  3480
cctgtctaa  cgcccaatg  cacttgggt  tggaggcag  ggccgtctg  ctctctggt  3540
agaggggaa  gctgatgct  agctctgtg  tgacaaaga  gaacacttt  aactggacc  3600
agaacctac  cctggcagg  accgaaaag  gcgtggggg  aagagtcag  agcggaagc  3660
gctgaagaa  gagcccatc  ggaagacca  gcgaaggag  agaggagag  atccagaag  3720
caaaagcaa  aaactacgc  accaagatg  ggctgacca  aacgccctc  ggatgatga  3780
ccggcttcg  gtttcttgg  ccatgcagg  ggatgggtt  ctaatgctc  gccgaattg  3840
cagcaatgt  ctcaacacc  aggtgaaag  accatttgt  acctggcag  tcgtgcgtg  3900
cattttgca  gctaccttt  aagagtctt  ggataaaac  tctcactcg  ttggacgaa  3960
agctcgcta  atagtcaaa  atccccagg  ctttatgaa  tacaaagtc  gcctggcag  4020
agtgtacca  gataaggca  tcgttggag  tttcatgag  cggaaggat  actacgaag  4080
cccaaaggt  tgtgccaag  agtttaaag  atttgtgga  aagctgaaa  agaagttca  4140
ctctggcct  aggaacccc  accttgaga  cccagacac  ctgcaggaa  tctttgcca  4200
ataccgggt  ttggcaatc  gagatgaaa  ggaccgtgt  aggaaggag  atgaactga  4260
tagtgtgga  gacatccac  tcctggtgc  acagaacct  atccagagc  cactgtccc  4320
ctctaacag  cagtccaac  cttgccagt  cttccagat  ttccgcctc  accgggagt  4380
ccgggagcc  gtgctggtg  gggccttca  ggagtgcca  aagaggagc  tggtcaacc  4440
acgccgtgt  agccactcc  agggtccca  gaagaaccg  gctgtgccc  ttgtgccca  4500
gtcctacca  ctctcccag  catactaca  gcttttcac  tggcgattt  ccaccaccg  4560
ctgcaccga  tccttccag  tctatgaca  actacgggc  aacggcata  tagaccagc  4620
tgatcattt  tctttcaag  acatggata  caatgaccc  tcaagtgac  tggtggcgt  4680
ttctttgga  agccctgga  gacactgtg  gacagccct  gccctcttc  ccttgggcc  4740
cctctctgt  gatgtccga  tcccagagc  gattgtggt  gtagacagc  ccatggtgg  4800
gagtgaggt  atgaagagc  tggggaaag  tggcggctt  gatgatgat  atgaggagg  4860
agacctgga  gaaggttca  ggaccaagc  tcagagtgt  gaagtaaag  cccatcagg  4920
ctcacacac  aagtacctg  tgatgagag  ttactacac  gtgcctggc  tggtcagca  4980
gcgcaacct  aaccccaat  acagcattg  ggtcaattc  tgccaggtt  aattccgac  5040
gcgcaatac  cctgcaccc  cccatcttg  gcccactgg  cccacagcc  caccgctag  5100
agagctcca  gctggccct  cctgcctcc  tgcctcctt  accagcctg  tggatccac  5160
gctgcacac  cgctgccca  aagagtttg  ccaccagat  gcacagtct  ggtacagcc  5220
tgaggacgt  gctgcgtcc  tagagatcc  gcaggctgt  gcagctgct  actgcttcg  5280
ggttgacag  gagaagctg  gcagacagt  ctctgcctt  gagaagata  cggacaagc  5340
caccaggac  ttcctggac  atatccagg  cctcttgga  cagcaacaa  tcatggaag  5400
tggaggcaa  actgtgcgc  tagtggcca  ggcctctgc  cagccctgg  tcctgcctt  5460
agtgcgtct  aaagatgtg  aaatagaca  caaggcctc  ggggatgac  gccaatcta  5520
actccctgc  gggtcttcc  tcgaagacc  cacctctga  ggtgcacca  ttcctccag  5580
cagctccaa  ggcactaaa  agcgcccct  ctgctctat  cagagccct  aaactgatg  5640
tgaggaagc  acaaggctc  ctgccaaga  gcccacatt  caagatgtc  gtgtggctg  5700
cagtcctag  cctggaaca  aagagcaga  agaggccca  gctcagttt  cagctcctg  5760
agatgcagg  gcagagggc  ccaggcagg  gagccaaga  agtgttggt  tctcaggcc  5820
agagcagct  ggctgtgag  tccagcttc  agaaaattc  gaagacccc  gaggactta  5880
agagagcaa  atggcccag  tagcatggg  gagcggctg  gaaagagta  gttttgtcg  5940
tcgcccatg  cgtggtgtg  acgggcgcc  gaacatgcc  gtgtgcaaa  gcatgatgg  6000
agccgtgct  taccacatc  tgtcaaggc  cggtgttcc  gagagctgc  tgctacagt  6060
ctaccaggg  gtcctacag  ctgttgctg  gcttgagct  ctccggggc  tagagtctc  6120
cggctgtat  cagaagcgg  tgctgaaga  gccagcgag  gtctcactc  tctccaggc  6180
tgtggtgga  ggcctaggt  aggccagtg  ggccgaggc  ctctcctgt  aggggagca  6240
tgtcacctt  tatgaacct  ctctggact  taccatccg  ctgggccgt  tcttccccc  6300
tgacatcaa  tggaaacaa  gtggatcca  ttatagatg  gtcccaggc  agcagagga  6360
cctctgccc  tgcttaatt  ttccgcctg  actgtccca  gagccccgt  cttcacaca  6420
ctgttacca  agctcggcc  agcctagca  aggtgtagc  actagcagg  gacttcagt  6480
ccctctgct  tcggctgct  ttggtccca  gtgcccagc  ttcctgcag  cctgtgtcc  6540
gccctggac  caggctcta  catcagcag  atctgcaag  gatgttgtt  agggagcag  6600
ctgatgacc  agccctgag  cacctcaca  gcaccacac  attcagact  agaggaaga  6660
acatcacag  tgtacctgg  agagtctgc  cctcttaag  tagggcatc  caacttggc  6720
tgaactgag  tcaggtctc  agctcccaa  ggcccctcc  gccagaagc  aggcctgta  6780
gttttgctt  tgtttttgt  ttattttgc  ctcttttca  tagatacaa  cccctggca  6840
gtatttatt  attttttaa  taaagtaag  tgaaatgc  6878



<210> 3158
<211> 2149
<212> PRT
<213> Rattus norvegicus
<308> L28801
<400> 3158

Met Asp Ala Leu Glu Ser Leu Leu Asp Glu Val Ala Leu Glu Gly Leu 
  1               5                  10                  15
Asp Gly Leu Cys Leu Pro Ala Leu Trp Ser Arg Leu Glu Ser Arg Ser 
             20                  25                  30
Pro Ala Phe Pro Leu Pro Leu Glu Pro Tyr Thr Gln Glu Phe Leu Trp 
         35                  40                  45
Arg Ala Leu Val Thr His Pro Gly Ile Ser Phe Tyr Glu Glu Pro Arg 
     50                  55                  60
Glu Arg Pro Asp Leu Gln Leu Gln Asp Arg Tyr Glu Glu Ile Asp Leu 
 65                  70                  75                  80
Glu Thr Gly Ile Leu Glu Ser Arg Arg Asp Pro Val Thr Leu Glu Asp 
                 85                  90                  95
Val Tyr Pro Ile His Met Ile Leu Glu Asn Lys Asp Gly Ile Gln Gly 
             100                105                110
Ser Cys Arg Tyr Phe Lys Glu Arg Lys Asp Ile Thr Ser Ser Ile Arg 
         115                120                125
Ser Lys Cys Leu Gln Pro Arg Cys Thr Met Val Glu Ala Phe Ser Arg 
     130                135                140
Trp Gly Lys Lys Leu Ile Ile Val Ala Ser Gln Asp Met Arg Tyr Arg 
 145                150                155                160
Ala Leu Ile Gly Leu Glu Gly Asp Pro Asp Leu Lys Leu Pro Asp Phe 
                 165                170                175
Ser Tyr Cys Ile Leu Glu Arg Leu Gly Arg Ser Arg Trp Gln Gly Glu 
             180                185                190
Leu Gln Arg Asp Leu His Thr Thr Ala Phe Lys Val Asp Ala Gly Lys 
         195                200                205
Leu His Tyr His Arg Lys Ile Leu Asn Lys Asn Gly Leu Ile Thr Met 
     210                215                220
Gln Ser His Val Ile Arg Leu Pro Thr Gly Ala Gln Gln His Ser Ile 
 225                230                235                240
Leu Leu Leu Leu Asn Arg Phe His Val Asp Arg Arg Ser Lys Tyr Asp 
                 245                250                255
Ile Leu Met Glu Lys Leu Ser Met Met Leu Ser Thr Arg Ser Asn Gln 
             260                265                270
Ile Glu Thr Leu Gly Lys Leu Arg Glu Glu Leu Gly Leu Cys Glu Arg 
         275                280                285
Thr Phe Lys Arg Leu Tyr Gln Tyr Met Leu Asn Ala Gly Leu Ala Lys 
     290                295                300
Val Val Ser Leu Pro Leu Gln Glu Ile His Pro Glu Cys Gly Pro Cys 
 305                310                315                320
Lys Thr Lys Lys Gly Thr Asp Val Met Val Arg Cys Leu Lys Leu Leu 
                 325                330                335
Lys Glu Phe Arg Arg Lys Met Glu Asp Asp His Asp Asp Asp Asp Asp 
             340                345                350
Glu Glu Ala Ile Ser Lys Ala Val Pro Pro Val Asp Ile Val Phe Glu 
         355                360                365
Arg Asp Met Leu Thr Gln Thr Tyr Glu Leu Ile Glu Arg Arg Gly Thr 
     370                375                380
Lys Gly Ile Ser Gln Ala Glu Ile Arg Val Ala Met Asn Val Gly Lys 
 385                390                395                400
Leu Glu Ala Arg Met Leu Cys Arg Leu Leu Gln Arg Phe Lys Val Val 
                 405                410                415
Lys Gly Phe Met Glu Asp Glu Gly Arg Gln Arg Thr Thr Lys Tyr Ile 
             420                425                430
Ser Cys Val Phe Ala Glu Glu Ser Asp Leu Ser Arg Gln Tyr Ala Arg 
         435                440                445
Glu Lys Ala Arg Gly Glu Leu Leu Thr Thr Val Ser Leu Ala Ser Val 
     450                455                460
Gln Asp Glu Ser Leu Met Pro Glu Gly Glu Glu Ala Phe Leu Ser Asp 
 465                470                475                480
Ser Glu Ser Glu Glu Glu Ser Ser Cys Ser Gly Lys Arg Arg Gly Arg 
                 485                490                495
Gly Ser Arg Gly His Ser Arg Ala Ser Gly Asp Ala Gly Pro Gly Ser 
             500                505                510
Arg Pro His His Ser Thr Pro Ala Lys Gly Gly Trp Lys Val Leu Asn 
         515                520                525
Leu His Pro Leu Lys Lys Pro Lys Ser Ala Ala Val Glu Arg Ser Arg 
     530                535                540
Arg Ser Ser Ala Cys Arg Asp Gly Leu Asp Thr Ser Ser Ser Ser Glu 
 545                550                555                560
Leu Asn Ile Pro Phe Asp Pro His Ser Met Asp Ser His Ser Gly Asp 
                 565                570                575
Ile Ala Val Ile Glu Glu Val Arg Leu Asp Asn Pro Lys Glu Gly Gly 
             580                585                590
Gly Ser Gln Lys Gly Gly Arg His Gly Ser Gly Gln Asp Lys Pro His 
         595                600                605
Lys Thr Tyr Arg Leu Leu Lys Arg Arg Asn Leu Ile Ile Glu Ala Val 
     610                615                620
Thr Asn Leu Arg Leu Ile Glu Ser Leu Phe Thr Ile Gln Lys Met Ile 
 625                630                635                640
Met Asp Gln Glu Lys Gln Glu Gly Val Ser Thr Lys Cys Cys Lys Lys 
                 645                650                655
Ser Ile Ile Arg Leu Val Arg Asn Leu Ser Glu Glu Gly Leu Leu Arg 
             660                665                670
Leu Tyr Arg Thr Thr Val Ile Gln Asp Gly Ile Lys Lys Lys Val Asp 
         675                680                685
Leu Val Val His Pro Ser Met Asp Gln Asn Asp Pro Leu Val Arg Ser 
     690                695                700
Ala Ile Glu Gln Val Arg Phe Arg Ile Ser Asn Ser Ser Thr Ala Asn 
 705                710                715                720
Arg Val Lys Val Pro Pro Ala Pro Ala Pro Gln Glu Glu Ala Glu Glu 
                 725                730                735
Gly Asn Gln Glu Pro Glu Val Pro Ser Arg Ser Ala Asp Ser Glu Ala 
             740                745                750
Asn Thr Ser Ser Lys Pro Glu Ser Thr Arg Val Lys Lys Thr Asp Glu 
         755                760                765
Lys Met Gly Ile Thr Pro Leu Lys Asn Tyr Lys Pro Val Ile Val Pro 
     770                775                780
Gly Leu Gly Arg Ser Ile Gly Phe Leu Pro Lys Met Pro Arg Leu Arg 
 785                790                795                800
Val Met His Leu Phe Leu Trp Tyr Leu Val Tyr Gly His Pro Ala Ser 
                 805                810                815
His Thr Gly Glu Gln Pro Thr Phe His Ser Glu Arg Lys Thr Gly Lys 
             820                825                830
Gln Glu Pro Ser Arg Pro Gly Val Gln Pro Ser Ser Gly Asp Asp Trp 
         835                840                845
Asp Ser Ser Glu Ala Lys Asn Ser Thr Glu Ser Ser Ser Trp Glu Ala 
     850                855                860
Glu Met Glu Leu Ser Thr Glu Arg Val Tyr Val Asp Glu Ile Ser Trp 
 865                870                875                880
Met Arg Tyr Val Pro Pro Ile Pro Ile His Arg Asp Phe Gly Phe Gly 
                 885                890                895
Trp Ala Leu Val Ser Asp Ile Leu Leu Cys Leu Pro Leu Ser Ile Phe 
             900                905                910
Val Gln Val Val Gln Val Ser Tyr Lys Val Asp Asn Leu Glu Asp Phe 
         915                920                925
Leu Asn Asp Pro Leu Lys Lys His Thr Leu Ile Arg Phe Leu Pro Arg 
     930                935                940
His Ile Arg Gln Gln Leu Leu Tyr Lys Arg Arg Tyr Ile Phe Ser Val 
 945                950                955                960
Val Glu Asn Leu Gln Arg Leu Cys Tyr Met Gly Leu Leu Gln Phe Gly 
                 965                970                975
Pro Thr Glu Lys Phe Gln Asp Lys Asp Gln Val Phe Val Phe Leu Lys 
             980                985                990
Lys Asn Ala Val Ile Val Asp Thr Thr Ile Cys Asp Pro His Tyr Asn 
         995                1000                1005
Leu Ala His Ser Ser Arg Pro Phe Glu Arg Arg Leu Tyr Val Leu Asp 
     1010                1015                1020
Ser Met Gln Asp Val Glu Ser Tyr Trp Phe Asp Leu Gln Cys Ile Cys 
 1025                1030                1035                1040
Leu Asn Thr Pro Leu Gly Val Val Arg Cys Pro Cys Ala Gln Lys Ile 
                 1045                1050                1055
Cys Pro Asp Pro Gly Ser Asp Pro Glu Gly Ser Leu Arg Lys Glu Gln 
             1060                1065                1070
Glu Ser Ala Met Asp Lys His Asn Leu Glu Arg Lys Cys Ala Met Leu 
         1075                1080                1085
Glu Tyr Thr Thr Gly Ser Arg Glu Val Val Asp Glu Gly Leu Val Pro 
     1090                1095                1100
Gly Asp Gly Leu Gly Ala Ala Gly Leu Asp Ser Ser Phe Tyr Ala His 
 1105                1110                1115                1120
Leu Lys Arg Asn Trp Val Trp Thr Ser Tyr Ile Ile Asn Lys Ala Arg 
                 1125                1130                1135
Lys Asn Asn Thr Ser Glu Asn Gly Leu Thr Gly Arg Leu Gln Thr Phe 
             1140                1145                1150
Leu Ser Lys Arg Pro Met Pro Leu Gly Ser Gly Gly Ser Gly Arg Leu 
         1155                1160                1165
Pro Leu Trp Ser Glu Gly Lys Ala Asp Ala Glu Leu Cys Ala Asp Lys 
     1170                1175                1180
Glu Glu His Phe Glu Leu Asp Arg Glu Pro Thr Pro Gly Arg Asn Arg 
 1185                1190                1195                1200
Lys Val Arg Gly Gly Lys Ser Gln Lys Arg Lys Arg Leu Lys Lys Glu 
                 1205                1210                1215
Pro Ile Arg Lys Thr Lys Arg Arg Arg Arg Gly Glu His Pro Glu Ala 
             1220                1225                1230
Lys Ser Lys Lys Leu Arg Tyr Gln Asp Glu Ala Asp Gln Asn Ala Leu 
         1235                1240                1245
Arg Met Met Thr Arg Leu Arg Val Ser Trp Ser Met Gln Glu Asp Gly 
     1250                1255                1260
Leu Leu Met Leu Cys Arg Ile Ala Ser Asn Val Leu Asn Thr Lys Val 
 1265                1270                1275                1280
Lys Gly Pro Phe Val Thr Trp Gln Val Val Arg Asp Ile Leu His Ala 
                 1285                1290                1295
Thr Phe Glu Glu Ser Leu Asp Lys Thr Ser His Ser Val Gly Arg Arg 
             1300                1305                1310
Ala Arg Tyr Ile Val Lys Asn Pro Gln Ala Phe Met Asn Tyr Lys Val 
         1315                1320                1325
Cys Leu Ala Glu Val Tyr Gln Asp Lys Ala Leu Val Gly Asp Phe Met 
     1330                1335                1340
Ser Arg Lys Asp Asn Tyr Glu Asp Pro Lys Val Cys Ala Lys Glu Phe 
 1345                1350                1355                1360
Lys Glu Phe Val Glu Lys Leu Lys Glu Lys Phe Ser Ser Gly Leu Arg 
                 1365                1370                1375
Asn Pro Asn Leu Glu Ile Pro Asp Thr Leu Gln Glu Leu Phe Ala Lys 
             1380                1385                1390
Tyr Arg Val Leu Ala Ile Gly Asp Glu Lys Asp Arg Val Arg Lys Glu 
         1395                1400                1405
Asp Glu Leu Asn Ser Val Glu Asp Ile His Phe Leu Val Leu Gln Asn 
     1410                1415                1420
Leu Ile Gln Ser Thr Leu Ser Leu Ser Asn Ser Gln Ser Asn Ser Cys 
 1425                1430                1435                1440
Gln Ser Phe Gln Ile Phe Arg Leu Tyr Arg Glu Phe Arg Glu Pro Val 
                 1445                1450                1455
Leu Val Arg Ala Phe Met Glu Cys Gln Lys Arg Ser Leu Val Asn Arg 
             1460                1465                1470
Arg Arg Val Ser His Ser Gln Gly Pro Lys Lys Asn Arg Ala Val Pro 
         1475                1480                1485
Phe Val Pro Met Ser Tyr Gln Leu Ser Gln Ser Tyr Tyr Lys Leu Phe 
     1490                1495                1500
Thr Trp Arg Phe Pro Thr Thr Val Cys Thr Glu Ser Phe Gln Phe Tyr 
 1505                1510                1515                1520
Asp Arg Leu Arg Ala Asn Gly Ile Leu Asp Gln Pro Asp His Phe Ser 
                 1525                1530                1535
Phe Lys Asp Met Asp Ser Asn Asp Pro Ser Ser Asp Leu Val Ala Phe 
             1540                1545                1550
Ser Leu Asp Ser Pro Gly Gly His Cys Val Thr Ala Leu Ala Leu Phe 
         1555                1560                1565
Ser Leu Gly Leu Leu Ser Val Asp Val Arg Ile Pro Glu Gln Ile Val 
     1570                1575                1580
Val Val Asp Ser Ser Met Val Glu Ser Glu Val Met Lys Ser Leu Gly 
 1585                1590                1595                1600
Lys Asp Gly Gly Leu Asp Asp Asp Asp Glu Glu Glu Asp Leu Asp Glu 
                 1605                1610                1615
Gly Ser Gly Thr Lys Arg Gln Ser Val Glu Val Lys Ala His Gln Ala 
             1620                1625                1630
Ser His Thr Lys Tyr Leu Leu Met Arg Gly Tyr Tyr Thr Val Pro Gly 
         1635                1640                1645
Met Val Ser Thr Arg Asn Leu Asn Pro Asn Asp Ser Ile Val Val Asn 
     1650                1655                1660
Ser Cys Gln Val Lys Phe Arg Leu Arg Asn Thr Pro Ala Pro Thr His 
 1665                1670                1675                1680
Leu Gly Pro Thr Gly Pro Thr Ala Thr Pro Leu Glu Glu Leu Gln Ala 
                 1685                1690                1695
Gly Pro Ser Cys Leu Pro Ala Ser Phe Thr Ser Leu Val Asp Pro Gln 
             1700                1705                1710
Leu His Thr Arg Cys Pro Glu Glu Phe Ala His Gln Met Ala Gln Ser 
         1715                1720                1725
Gly Tyr Ser Pro Glu Asp Val Ala Ala Ser Leu Glu Ile Leu Gln Ala 
     1730                1735                1740
Val Ala Ala Ala Asp Cys Phe Gly Val Asp Arg Glu Lys Leu Ser Arg 
 1745                1750                1755                1760
Gln Phe Ser Ala Leu Glu Lys Ile Ala Asp Lys Arg Thr Arg Thr Phe 
                 1765                1770                1775
Leu Asp Tyr Ile Gln Asp Leu Leu Glu Gln Gln Gln Val Met Glu Val 
             1780                1785                1790
Gly Gly Asn Thr Val Arg Leu Val Ala Met Ala Ser Ala Gln Pro Trp 
         1795                1800                1805
Leu Leu Pro Ser Val Arg Leu Lys Asp Val Glu Ile Asp Thr Lys Ala 
     1810                1815                1820
Ser Gly Asp Asp Ser Gln Ser Arg Leu Pro Ala Gly Ser Ser Ile Glu 
 1825                1830                1835                1840
Asp His Thr Ser Glu Gly Ala Pro Ile Pro Pro Val Ser Ser Asn Gly 
                 1845                1850                1855
Thr Lys Lys Arg Pro Tyr Cys Ser Ile Gln Ser Pro Glu Thr Asp Ala 
             1860                1865                1870
Glu Glu Ala Thr Arg Leu Pro Ala Lys Lys Pro Thr Leu Gln Asp Val 
         1875                1880                1885
Cys Val Ala Ala Ser Pro Arg Pro Gly Thr Glu Glu Gln Thr Glu Ala 
     1890                1895                1900
Gln Ala Gln Phe Ala Ala Pro Glu Asp Ala Gly Ala Glu Gly Pro Arg 
 1905                1910                1915                1920
Gln Glu Ser Gln Glu Ser Val Gly Val Ser Gly Leu Glu Gln Leu Gly 
                 1925                1930                1935
Cys Glu Phe Gln Leu Pro Glu Asn Ser Glu Asp Pro Arg Gly Leu Thr 
             1940                1945                1950
Glu Ser Asn Met Ala Gln Val Ala Trp Glu Ser Gly Cys Glu Arg Val 
         1955                1960                1965
Cys Phe Val Gly Arg Pro Trp Arg Gly Val Asp Gly Arg Leu Asn Met 
     1970                1975                1980
Pro Val Cys Lys Gly Met Met Glu Ala Val Leu Tyr His Ile Met Ser 
 1985                1990                1995                2000
Arg Pro Gly Val Pro Glu Ser Cys Leu Leu Gln Tyr Tyr Gln Gly Val 
                 2005                2010                2015
Leu Gln Pro Val Ala Val Leu Glu Leu Leu Arg Gly Leu Glu Ser Leu 
             2020                2025                2030
Gly Cys Ile Gln Lys Arg Met Leu Lys Lys Pro Ala Ser Val Ser Leu 
         2035                2040                2045
Phe Ser Arg Pro Val Val Glu Gly Leu Gly Gln Ala Ser Glu Ala Glu 
     2050                2055                2060
Ala Leu Ser Cys Gln Gly Ser Thr Val Thr Phe Tyr Glu Pro Thr Leu 
 2065                2070                2075                2080
Asp Cys Thr Ile Arg Leu Gly Arg Val Phe Pro His Asp Ile Asn Trp 
                 2085                2090                2095
Lys Gln Ser Gly Ser Ile Tyr Arg Cys Val Pro Gly Gln Gln Arg Ser 
             2100                2105                2110
Leu Cys Pro Cys Leu Ile Val Pro Pro Gly Leu Ser Gln Glu Pro Arg 
         2115                2120                2125
Pro Ser His Ser Cys Tyr Gln Ser Ser Ala Gln Pro Ser Thr Gly Val 
     2130                2135                2140
Ala Thr Ser Arg Ter 
 2145



<210> 3159
<211> 6996
<212> DNA
<213> Homo sapiens
<308> U02619
<400> 3159

atggaccaa  gcccttggc  gtgcgttgc  cacccccgg  gcgccgcga  tgaagtagc  60
atggacgcg  tggagtcgt  gttggacga  gtcgctctg  aggggctcg  tggcctgtg  120
ctgccagcg  tgtggagcc  gctggagac  cgagtgccg  ccttcccgc  gcctttgga  180
ccctgcacg  aggagtttc  ctggcgggc  ctcgccacg  acccgggca  cagcttcta  240
gaggagcct  gggagcgac  cgacctaca  ctccaggac  ggtatgaag  aattgattt  300
gaaactgga  ttttggagt  taggaggga  ccggtggct  tggaggatg  ctaccccat  360
catatgatc  tagagaata  ggatggcat  cagggctca  gccgctact  taaggagag  420
aaaaacatt  ccaatgaca  cagaaccaa  tccttgcag  ctcgctgta  aatggtgga  480
ccctttgac  ggtggggga  gaaactgat  atcggttcc  tcccagccc  tgcggtaca  540
gcccttgat  gcccaggag  gggatcccg  cctgaagct  cccgacttc  cctactgca  600
cctggaacg  ctaggccgg  ccaggtgca  ggggagctc  agcgagacc  tcacaccac  660
gctttcaag  ttgatgctg  gaagctgca  tatcacaga  aaattttga  caaaaacgg  720
ctgattaca  tgcagtccc  tgtgatccg  ttacccact  gagcccagc  acactcaat  780
ctcctccta  tgaaccggt  tcatgtgga  aggaggagc  aatacgaca  cctcatgga  840
aagctttcg  tcatgctga  cacacggac  aaccacata  agacgctgg  aaagctgag  900
gaagagctg  ggctgtgcg  aaggacgtt  aagcgtctg  accagtata  gctgaacgc  960
gggctagcc  aggtggtgt  tcttcgctt  caagagatc  accctgaat  tggaccttg  1020
aagacaaag  aagggaccg  cgtcatggt  cggtgcctc  agctgctga  ggaatttaa  1080
cggaatgac  atgatgatg  cgaggacga  gaggtcatc  ccaagacag  gcctccagt  1140
gacattgtg  tcgagcggg  tatgctcac  cagacctac  acctcattg  gcgcagagg  1200
acgaaagga  tttcccaag  tgaaatccg  gtggctatg  atgtgggaa  actagaagc  1260
agaatgctg  gccgacttc  tcaaagatt  aaagttgtc  agggattca  ggaagacga  1320
ggtcggcag  gaaccacca  gtacatttc  tgcgtgttt  cagaggaga  cgacctaag  1380
cggcagtac  aaagagaga  ggcccgcag  gagctcttg  ccaccgtga  cctggcgtc  1440
atgcaggag  agtcgcttc  gcctgaagg  gaggacacc  tcctctctg  gtcggacag  1500
gaggaggag  ggagcagca  caagcggag  ggcagaggg  cccagaaag  cacaagagc  1560
tctgcaaac  tccggccca  gacccagcc  catcactcc  ccccaacca  gggtgggtg  1620
aaagttgta  acctacacc  attgaaaaa  cagccgccc  ccttcccag  agctgctga  1680
gagagagcc  gccagagcc  tgccagcag  gacagcctc  tagatacca  cagcgtctc  1740
gaacccaac  tgtcctttg  ctcccactg  gcggacagc  acagtggtg  catagctgt  1800
atcgaggag  tccggatgg  aaacccaaa  gagagtagc  gttccctga  gactgggag  1860
cacagctca  gccaagaca  accacacga  acttaccga  tgctgaaac  caggaatct  1920
atcatagaa  ctgtcacca  tcttcgctt  atcgagagt  tattcacga  tcagaagat  1980
atcatggat  aggagaagc  ggaaggcgt  tccaccaag  gctgcaaga  gtccattgt  2040
cgcttggtg  ggaacctgt  tgaggaagg  ctcttgcga  tgtatcgga  cactgtcat  2100
caagatggc  tcaagaaga  ggtggatct  gtggtgcac  cgtccatgg  ccagaacga  2160
cctctagtg  gaagtgcca  cgagcaggt  cgcttccgg  tctccaatt  aagcacagc  2220
aacagggtt  aaacttccc  gcctccagt  ccccaaggg  aggcagaag  agacagtca  2280
ggaaaagag  gcccaagtg  atcagggga  tctcagctg  gtgcttcct  tagatcaga  2340
agtggacgg  tgaaaaaaa  tgataataa  atgggcata  ccccgctta  aaattatca  2400
cccattgta  ttcccggac  ggggcgttc  ctaggattt  tgcccaaaa  gcctcgcct  2460
cgggtggtc  acatgtttc  gtggtacct  atctacggg  accctgcca  caacaccgt  2520
gagaagcca  gcttcatca  tgaacggag  acgataaag  aggagtcag  cagggcagg  2580
gtccggccg  cctcctctg  aagtgcctg  gaggcctgc  ctgaagccc  atctaaagg  2640
agccaagat  gtgtcacct  ggaggctga  gtggagctt  ccacggaga  agtgtatgt  2700
gacgatgcc  cgtggatgc  ctacatccc  ccaatccca  tccacaggg  cttcggctt  2760
ggctgggct  tcgtcagcg  catcctcct  tgccttccc  tctccatct  catccagat  2820
gtgcaagtc  gctacaagg  ggacaacct  gaggaattt  tgaacgacc  gctgaagaa  2880
cacacgctg  tccgctttc  ccccaggcc  attcggcag  agcttctgt  caagaggcg  2940
tacattttt  cggtggtgg  gaaccttca  aggctgtgc  acatggggg  gctacagtt  3000
ggtcccacg  aaaagtttc  ggataaaga  caggtcttt  tcttcttga  gaagaatgc  3060
gtcattgtt  acactacca  ctgcgaccc  cattacaac  tgggccgca  gaggcggcc  3120
ttcgagagg  gcctctatg  cctgaactc  atgcaggat  tggaaaact  ctggtttga  3180
ctgcagtgc  tctgcctca  caccccact  ggcgtggtg  gctgcccgc  cgtcaggaa  3240
aacagcagc  cagaccagg  cagcgacga  gagggcagc  tgcagaagg  gcaggagag  3300
gccatggac  agcacaacc  ggagcgcaa  tgcgccatg  tggagtaca  cactggaag  3360
cgtgaggtg  tggatgaag  cttgatccc  ggagatggg  tgggtgccg  agggctcga  3420
tccagcttc  acggacacc  caagcgcaa  tggatctgg  ccagctaca  catcaacca  3480
gccaaaaag  agaacactg  cgcagagaa  ggactcaca  tgaggctcc  gacatttct  3540
tccaagcgc  caatgcccc  cagtgccag  ggcaacagc  ggttgaata  ttgggggga  3600
gcaagagta  gctccgagc  ctgtgctgg  tgggaagag  agtttgagg  ggaccgaga  3660
ccctcgctg  accgaaacc  gagagtgag  ggtgggaaa  gccagaagc  gaagcggct  3720
aagaaggac  ctgggaaga  gatcaagag  aagaagaaa  gagagttcc  aggagaaaa  3780
agcaaaagg  tgcgctacc  tgatgaagc  gaccagagt  ccctgcatc  gatgacgcg  3840
cttcgtgtc  cctggtcta  gcaggagga  gggctgctt  tgctgtgcc  cattgccag  3900
aatgtcctc  acaccaagg  gaagggtcc  tttgtcacc  ggcaggtgg  acgggacat  3960
ttgcatgcc  cgtttgaag  gtctttgga  aaaacatct  attcccttg  acgaagagc  4020
cgctacata  tcaaaaacc  acaggccta  ctcaactat  aagtgtgcc  ggccgaggt  4080
taccaggat  aagcacttg  tggagattt  atgaatcga  gaggtgact  tgatgaccc  4140
aaggtttgt  ccaacgagt  taaagaatt  gtggagaag  ttaaagaaa  gttcagttc  4200
gccctaagg  attctaacc  tgaaatccc  gacacactc  aggagctgt  cgccaggta  4260
cgagttttg  caattgggg  tgaaaaaga  caaaccagg  aagaggatg  acttaacag  4320
gtggatgac  tccactttc  ggtgcttca  aacctgatc  agagcacgc  ggccctctc  4380
gacagtcag  tgaagtcct  ccagtcatt  cagactttc  gcctctatc  ggagtacaa  4440
gaccacgtt  ttgtgaagg  cttcatgga  tgccagaag  ggagcttgg  caaccggcg  4500
cgggtcaac  acacgctgg  ccccaagaa  aaccgggcc  tccccttcg  gccaatgtc  4560
taccagcta  cccagacct  ctacaggat  tttacgtgg  gatttccaa  caccatctg  4620
acggagtca  tccagtttt  ggacagaat  cgggctgcc  gcaagttgg  ccagcctga  4680
cgtttctct  tcaaagacc  ggataataa  gagcccaca  acgacatgg  ggccttttc  4740
ctggacggc  ctggaggaa  ttgtgtggc  gtcctgacc  tcttctctc  gggcctcat  4800
tctgtggat  tcaggatcc  ggagcagat  atcgtggta  acagctcaa  ggtggagaa  4860
gaggtcatc  aaagcttgg  gaaggacgg  agcctggag  atgacgagg  tgaagagga  4920
gacttggac  aaggtgtag  gggcaagcg  cggagcatg  aggtgaaac  tgcgcaagc  4980
tcccacacc  actacctgc  gatgagggg  tactactcc  ccggcatcg  cagcacccg  5040
aacctcaac  ccaacgaca  cattgtggt  aactcctgc  agatgaagt  ccagctccg  5100
tgcacccct  tgcccgccc  gctcaggcc  gctgccgct  ctctggaag  gctaacaat  5160
ggaacctcc  gcctccctg  tacgttcac  aagctgata  acccccagg  aaacacctg  5220
agcttggag  agtttgtcc  ccagctgga  ctgtctggg  atagtcccg  agacctgac  5280
gctgccttg  agatcttgg  agccattat  gccacgggt  gttttggga  tgacaagga  5340
gagctgcgc  gacggttct  ggccttgga  aaggcaggt  gtgggcgca  caggacatt  5400
gcagattgc  tccaggccc  cctggagca  catcaggtg  tggaggtcg  tggcaacac  5460
gcgcgcctg  tagccatgg  ctctgcctg  ccttggctc  tgcactccg  gcggctgaa  5520
gacagagaa  acgccgaca  ccagagaga  gacccccag  ccagacccc  ggaggggtc  5580
tccagtgag  acagccccc  cgaggggca  gcacctcct  ctcacagcc  ccggggcac  5640
aagaggcgc  ccagctggg  cagtgagaa  ggggagacc  acgccgagg  cacccagat  5700
acccctgcc  agaggccag  gctccagga  tcaaatttg  cccccagcc  tgggcccgg  5760
gctgaagat  gggcagaag  ccaggcccc  tctccaccc  cagctcttg  agacaccgc  5820
gcagcggga  cagcacagg  agaccaaga  ggtgtcggt  agttcagtt  cccaggcca  5880
gagcagctg  gcggccagg  gcagcctcc  gagggctct  aagacccca  agggttcac  5940
gagagtttc  gagctgcca  catctccca  gcagcacgg  aaagggact  tgagagtgt  6000
tgcttcatc  gccggccgt  gcgtgtcgt  gatggccac  tgaaccttc  tgtatgcaa  6060
ggtatgatg  aggccatgc  gtaccacat  atgaccagg  ctggcatcc  cgagagctc  6120
ctgctgcgc  actaccagg  ggtcctgca  cccgtcgcc  tgctggagt  gctccaggg  6180
ctggagtcc  tcggctgca  ccggaagcg  tggctgaga  agccaaggc  tgtctcgct  6240
ttctctaca  ccgtggtgg  agaggtgga  gtgccctcc  gcctggacg  gagccccat  6300
gctttctat  agcccacct  ggactgtac  ctccggctg  gccgtgtgt  cccccacga  6360
gtcaactgg  acaagtgga  ccacctcta  gacccctgt  ggcgtcccc  ccctcccag  6420
caccgcctg  cacaccact  ctgcctggt  ctcggcaga  cccactgtg  cctggcctt  6480
ggtctgccg  gcctcctgc  gcaggggac  ggtgctttg  ccagagtca  agactgaca  6540
gtttcccac  gtactggaa  tctggaaag  ggggctccc  gacctgccc  tcccccagg  6600
tcttctggg  cttcccctt  ggaactggc  tcatcacac  gggagttgg  gcttcttgt  6660
tctgggtct  cagagtttg  cccgcctgt  cacacctca  attccagac  ctagccatc  6720
cggcaggat  tcctggctc  ttgagtgcc  aggtgccac  aagaggaag  gccttgtgg  6780
atacacctt  cagaatagg  atcggtgtg  cccgctgcg  ggggccccc  atgggggct  6840
tggcccctc  gcaggcagg  catcccaac  cctggctgg  actgaacca  ccagagcgg  6900
gcggctccc  tttcagcct  gtgagtcac  tggcaggcc  cagctgggc  ggctgtccg  6960
gtccctcag  ctggctggt  attccttgc  ggaggg  6996



<210> 3160
<211> 2110
<212> PRT
<213> Homo sapiens
<308> U02619
<400> 3160

Met Asp Ala Leu Glu Ser Leu Leu Asp Glu Val Ala Leu Glu Gly Leu 
  1               5                  10                  15
Asp Gly Leu Cys Leu Pro Ala Leu Trp Ser Arg Leu Glu Thr Arg Val 
             20                  25                  30
Pro Pro Phe Pro Leu Pro Leu Glu Pro Cys Thr Gln Glu Phe Leu Trp 
         35                  40                  45
Arg Ala Leu Ala Thr His Pro Gly Ile Ser Phe Tyr Glu Glu Pro Arg 
     50                  55                  60
Glu Arg Pro Asp Leu Gln Leu Gln Asp Arg Tyr Glu Glu Ile Asp Leu 
 65                  70                  75                  80
Glu Thr Gly Ile Leu Glu Ser Arg Arg Asp Pro Val Ala Leu Glu Asp 
                 85                  90                  95
Val Tyr Pro Ile His Met Ile Leu Glu Asn Lys Asp Gly Ile Gln Gly 
             100                105                110
Ser Cys Arg Tyr Phe Lys Glu Arg Lys Asn Ile Thr Asn Asp Ile Arg 
         115                120                125
Thr Lys Ser Leu Gln Pro Arg Cys Thr Met Val Glu Pro Phe Asp Arg 
     130                135                140
Trp Gly Lys Lys Leu Ile Ile Gly Ser Leu Pro Ala His Ala Val Gln 
 145                150                155                160
Ala Leu Asp Ser Pro Gly Gly Gly Ser Arg Pro Glu Ala Ala Arg Leu 
                 165                170                175
Leu Leu Leu His Pro Gly Thr Ala Arg Pro Val Gln Val Gln Gly Glu 
             180                185                190
Leu Gln Arg Asp Leu His Thr Thr Ala Phe Lys Val Asp Ala Gly Lys 
         195                200                205
Leu His Tyr His Arg Lys Ile Leu Asn Lys Asn Gly Leu Ile Thr Met 
     210                215                220
Gln Ser His Val Ile Arg Leu Pro Thr Gly Ala Gln Gln His Ser Ile 
 225                230                235                240
Leu Leu Leu Leu Asn Arg Phe His Val Asp Arg Arg Ser Lys Tyr Asp 
                 245                250                255
Ile Leu Met Glu Lys Leu Ser Val Met Leu Ser Thr Arg Thr Asn His 
             260                265                270
Ile Glu Thr Leu Gly Lys Leu Arg Glu Glu Leu Gly Leu Cys Glu Arg 
         275                280                285
Thr Phe Lys Arg Leu Tyr Gln Tyr Met Leu Asn Ala Gly Leu Ala Lys 
     290                295                300
Val Val Ser Leu Arg Leu Gln Glu Ile His Pro Glu Cys Gly Pro Cys 
 305                310                315                320
Lys Thr Lys Lys Gly Thr Asp Val Met Val Arg Cys Leu Lys Leu Leu 
                 325                330                335
Lys Glu Phe Lys Arg Asn Asp His Asp Asp Asp Glu Asp Glu Glu Val 
             340                345                350
Ile Ser Lys Thr Val Pro Pro Val Asp Ile Val Phe Glu Arg Asp Met 
         355                360                365
Leu Thr Gln Thr Tyr Asp Leu Ile Glu Arg Arg Gly Thr Lys Gly Ile 
     370                375                380
Ser Gln Ala Glu Ile Arg Val Ala Met Asn Val Gly Lys Leu Glu Ala 
 385                390                395                400
Arg Met Leu Cys Arg Leu Leu Gln Arg Phe Lys Val Val Lys Gly Phe 
                 405                410                415
Met Glu Asp Glu Gly Arg Gln Arg Thr Thr Lys Tyr Ile Ser Cys Val 
             420                425                430
Phe Ala Glu Glu Ser Asp Leu Ser Arg Gln Tyr Gln Arg Glu Lys Ala 
         435                440                445
Arg Ser Glu Leu Leu Thr Thr Val Ser Leu Ala Ser Met Gln Glu Glu 
     450                455                460
Ser Leu Leu Pro Glu Gly Glu Asp Thr Phe Leu Ser Glu Ser Asp Ser 
 465                470                475                480
Glu Glu Glu Arg Ser Ser Ser Lys Arg Arg Gly Arg Gly Ser Gln Lys 
                 485                490                495
Asp Thr Arg Ala Ser Ala Asn Leu Arg Pro Lys Thr Gln Pro His His 
             500                505                510
Ser Thr Pro Thr Lys Gly Gly Trp Lys Val Val Asn Leu His Pro Leu 
         515                520                525
Lys Lys Gln Pro Pro Ser Phe Pro Gly Ala Ala Glu Glu Arg Ala Cys 
     530                535                540
Gln Ser Leu Ala Ser Arg Asp Ser Leu Leu Asp Thr Ser Ser Val Ser 
 545                550                555                560
Glu Pro Asn Val Ser Phe Val Ser His Cys Ala Asp Ser Asn Ser Gly 
                 565                570                575
Asp Ile Ala Val Ile Glu Glu Val Arg Met Glu Asn Pro Lys Glu Ser 
             580                585                590
Ser Ser Ser Leu Lys Thr Gly Arg His Ser Ser Gly Gln Asp Lys Pro 
         595                600                605
His Glu Thr Tyr Arg Leu Leu Lys Arg Arg Asn Leu Ile Ile Glu Ala 
     610                615                620
Val Thr Asn Leu Arg Leu Ile Glu Ser Leu Phe Thr Ile Gln Lys Met 
 625                630                635                640
Ile Met Asp Gln Glu Lys Gln Glu Gly Val Ser Thr Lys Cys Cys Lys 
                 645                650                655
Lys Ser Ile Val Arg Leu Val Arg Asn Leu Ser Glu Glu Gly Leu Leu 
             660                665                670
Arg Leu Tyr Arg Thr Thr Val Ile Gln Asp Gly Ile Lys Lys Lys Val 
         675                680                685
Asp Leu Val Val His Pro Ser Met Asp Gln Asn Asp Pro Leu Val Arg 
     690                695                700
Ser Ala Ile Glu Gln Val Arg Phe Arg Ile Ser Asn Ser Ser Thr Ala 
 705                710                715                720
Asn Arg Val Lys Thr Ser Gln Pro Pro Val Pro Gln Gly Glu Ala Glu 
                 725                730                735
Glu Asp Ser Gln Gly Lys Glu Gly Pro Ser Gly Ser Gly Asp Ser Gln 
             740                745                750
Leu Ser Ala Ser Ser Arg Ser Glu Ser Gly Arg Met Lys Lys Ser Asp 
         755                760                765
Asn Lys Met Gly Ile Thr Pro Leu Arg Asn Tyr His Pro Ile Val Val 
     770                775                780
Pro Gly Leu Gly Arg Ser Leu Gly Phe Leu Pro Lys Met Pro Arg Leu 
 785                790                795                800
Arg Val Val His Met Phe Leu Trp Tyr Leu Ile Tyr Gly His Pro Ala 
                 805                810                815
Ser Asn Thr Val Glu Lys Pro Ser Phe Ile Ser Glu Arg Arg Thr Ile 
             820                825                830
Lys Gln Glu Ser Gly Arg Ala Gly Val Arg Pro Ser Ser Ser Gly Ser 
         835                840                845
Ala Trp Glu Ala Cys Ser Glu Ala Pro Ser Lys Gly Ser Gln Asp Gly 
     850                855                860
Val Thr Trp Glu Ala Glu Val Glu Leu Ala Thr Glu Thr Val Tyr Val 
 865                870                875                880
Asp Asp Ala Ser Trp Met Arg Tyr Ile Pro Pro Ile Pro Val His Arg 
                 885                890                895
Asp Phe Gly Phe Gly Trp Ala Leu Val Ser Asp Ile Leu Leu Cys Leu 
             900                905                910
Pro Leu Ser Ile Phe Ile Gln Ile Val Gln Val Ser Tyr Lys Val Asp 
         915                920                925
Asn Leu Glu Glu Phe Leu Asn Asp Pro Leu Lys Lys His Thr Leu Ile 
     930                935                940
Arg Phe Leu Pro Arg Pro Ile Arg Gln Gln Leu Leu Tyr Lys Arg Arg 
 945                950                955                960
Tyr Ile Phe Ser Val Val Glu Asn Leu Gln Arg Leu Cys Tyr Met Gly 
                 965                970                975
Val Leu Gln Phe Gly Pro Thr Glu Lys Phe Gln Asp Lys Asp Gln Val 
             980                985                990
Phe Ile Phe Leu Lys Lys Asn Ala Val Ile Val Asp Thr Thr Ile Cys 
         995                1000                1005
Asp Pro His Tyr Asn Leu Gly Arg Arg Arg Arg Pro Phe Glu Arg Arg 
     1010                1015                1020
Leu Tyr Val Leu Asn Ser Met Gln Asp Val Glu Asn Tyr Trp Phe Asp 
 1025                1030                1035                1040
Leu Gln Cys Val Cys Leu Asn Thr Pro Leu Gly Val Val Arg Cys Pro 
                 1045                1050                1055
Arg Val Arg Lys Asn Ser Ser Thr Asp Gln Gly Ser Asp Glu Glu Gly 
             1060                1065                1070
Ser Leu Gln Lys Glu Gln Glu Ser Ala Met Asp Lys His Asn Leu Glu 
         1075                1080                1085
Arg Lys Cys Ala Met Leu Glu Tyr Thr Thr Gly Ser Arg Glu Val Val 
     1090                1095                1100
Asp Glu Gly Leu Ile Pro Gly Asp Gly Leu Gly Ala Ala Gly Leu Asp 
 1105                1110                1115                1120
Ser Ser Phe Tyr Gly His Leu Lys Arg Asn Trp Ile Trp Thr Ser Tyr 
                 1125                1130                1135
Ile Ile Asn Gln Ala Lys Lys Glu Asn Thr Ala Ala Glu Asn Gly Leu 
             1140                1145                1150
Thr Val Arg Leu Gln Thr Phe Leu Ser Lys Arg Pro Met Pro Leu Ser 
         1155                1160                1165
Ala Arg Gly Asn Ser Arg Leu Asn Ile Trp Gly Glu Ala Arg Val Gly 
     1170                1175                1180
Ser Glu Leu Cys Ala Gly Trp Glu Glu Gln Phe Glu Val Asp Arg Glu 
 1185                1190                1195                1200
Pro Ser Leu Asp Arg Asn Arg Arg Val Arg Gly Gly Lys Ser Gln Lys 
                 1205                1210                1215
Arg Lys Arg Leu Lys Lys Asp Pro Gly Lys Lys Ile Lys Arg Lys Lys 
             1220                1225                1230
Lys Gly Glu Phe Pro Gly Glu Lys Ser Lys Arg Leu Arg Tyr His Asp 
         1235                1240                1245
Glu Ala Asp Gln Ser Ala Leu His Arg Met Thr Arg Leu Arg Val Thr 
     1250                1255                1260
Trp Ser Met Gln Glu Asp Gly Leu Leu Val Leu Cys Arg Ile Ala Ser 
 1265                1270                1275                1280
Asn Val Leu Asn Thr Lys Val Lys Gly Pro Phe Val Thr Trp Gln Val 
                 1285                1290                1295
Val Arg Asp Ile Leu His Ala Thr Phe Glu Glu Ser Leu Asp Lys Thr 
             1300                1305                1310
Ser His Ser Leu Gly Arg Arg Ala Arg Tyr Ile Val Lys Asn Pro Gln 
         1315                1320                1325
Ala Tyr Leu Asn Tyr Lys Val Cys Leu Ala Glu Val Tyr Gln Asp Lys 
     1330                1335                1340
Ala Leu Val Gly Asp Phe Met Asn Arg Arg Gly Asp Tyr Asp Asp Pro 
 1345                1350                1355                1360
Lys Val Cys Ala Asn Glu Phe Lys Glu Phe Val Glu Lys Leu Lys Glu 
                 1365                1370                1375
Lys Phe Ser Ser Ala Leu Arg Asn Ser Asn Leu Glu Ile Pro Asp Thr 
             1380                1385                1390
Leu Gln Glu Leu Phe Ala Arg Tyr Arg Val Leu Ala Ile Gly Asp Glu 
         1395                1400                1405
Lys Asp Gln Thr Arg Lys Glu Asp Glu Leu Asn Ser Val Asp Asp Ile 
     1410                1415                1420
His Phe Leu Val Leu Gln Asn Leu Ile Gln Ser Thr Leu Ala Leu Ser 
 1425                1430                1435                1440
Asp Ser Gln Met Lys Ser Tyr Gln Ser Phe Gln Thr Phe Arg Leu Tyr 
                 1445                1450                1455
Arg Glu Tyr Lys Asp His Val Leu Val Lys Ala Phe Met Glu Cys Gln 
             1460                1465                1470
Lys Arg Ser Leu Val Asn Arg Arg Arg Val Asn His Thr Leu Gly Pro 
         1475                1480                1485
Lys Lys Asn Arg Ala Leu Pro Phe Val Pro Met Ser Tyr Gln Leu Ser 
     1490                1495                1500
Gln Thr Tyr Tyr Arg Ile Phe Thr Trp Arg Phe Pro Ser Thr Ile Cys 
 1505                1510                1515                1520
Thr Glu Ser Phe Gln Phe Leu Asp Arg Met Arg Ala Ala Gly Lys Leu 
                 1525                1530                1535
Asp Gln Pro Asp Arg Phe Ser Phe Lys Asp Gln Asp Asn Asn Glu Pro 
             1540                1545                1550
Thr Asn Asp Met Val Ala Phe Ser Leu Asp Gly Pro Gly Gly Asn Cys 
         1555                1560                1565
Val Ala Val Leu Thr Leu Phe Ser Leu Gly Leu Ile Ser Val Asp Val 
     1570                1575                1580
Arg Ile Pro Glu Gln Ile Ile Val Val Asp Ser Ser Met Val Glu Asn 
 1585                1590                1595                1600
Glu Val Ile Lys Ser Leu Gly Lys Asp Gly Ser Leu Glu Asp Asp Glu 
                 1605                1610                1615
Asp Glu Glu Asp Asp Leu Asp Glu Gly Val Gly Gly Lys Arg Arg Ser 
             1620                1625                1630
Met Glu Val Lys Pro Ala Gln Ala Ser His Thr Asn Tyr Leu Leu Met 
         1635                1640                1645
Arg Gly Tyr Tyr Ser Pro Gly Ile Val Ser Thr Arg Asn Leu Asn Pro 
     1650                1655                1660
Asn Asp Ser Ile Val Val Asn Ser Cys Gln Met Lys Phe Gln Leu Arg 
 1665                1670                1675                1680
Cys Thr Pro Val Pro Ala Arg Leu Arg Pro Ala Ala Ala Pro Leu Glu 
                 1685                1690                1695
Glu Leu Thr Met Gly Thr Ser Cys Leu Pro Asp Thr Phe Thr Lys Leu 
             1700                1705                1710
Ile Asn Pro Gln Glu Asn Thr Cys Ser Leu Glu Glu Phe Val Leu Gln 
         1715                1720                1725
Leu Glu Leu Ser Gly Tyr Ser Pro Glu Asp Leu Thr Ala Ala Leu Glu 
     1730                1735                1740
Ile Leu Glu Ala Ile Ile Ala Thr Gly Cys Phe Gly Ile Asp Lys Glu 
 1745                1750                1755                1760
Glu Leu Arg Arg Arg Phe Ser Ala Leu Glu Lys Ala Gly Gly Gly Arg 
                 1765                1770                1775
Thr Arg Thr Phe Ala Asp Cys Ile Gln Ala Leu Leu Glu Gln His Gln 
             1780                1785                1790
Val Leu Glu Val Gly Gly Asn Thr Ala Arg Leu Val Ala Met Gly Ser 
         1795                1800                1805
Ala Trp Pro Trp Leu Leu His Ser Val Arg Leu Lys Asp Arg Glu Asp 
     1810                1815                1820
Ala Asp Ile Gln Arg Glu Asp Pro Gln Ala Arg Pro Leu Glu Gly Ser 
 1825                1830                1835                1840
Ser Ser Glu Asp Ser Pro Pro Glu Gly Gln Ala Pro Pro Ser His Ser 
                 1845                1850                1855
Pro Arg Gly Thr Lys Arg Arg Ala Ser Trp Ala Ser Glu Asn Gly Glu 
             1860                1865                1870
Thr Asp Ala Glu Gly Thr Gln Met Thr Pro Ala Lys Arg Pro Ala Leu 
         1875                1880                1885
Gln Asp Ser Asn Leu Ala Pro Ser Leu Gly Pro Gly Ala Glu Asp Gly 
     1890                1895                1900
Ala Glu Ala Gln Ala Pro Ser Pro Pro Pro Ala Leu Glu Asp Thr Ala 
 1905                1910                1915                1920
Ala Ala Gly Ala Ala Gln Glu Asp Gln Glu Gly Val Gly Glu Phe Ser 
                 1925                1930                1935
Ser Pro Gly Gln Glu Gln Leu Ser Gly Gln Ala Gln Pro Pro Glu Gly 
             1940                1945                1950
Ser Glu Asp Pro Arg Gly Phe Thr Glu Ser Phe Gly Ala Ala Asn Ile 
         1955                1960                1965
Ser Gln Ala Ala Arg Glu Arg Asp Cys Glu Ser Val Cys Phe Ile Gly 
     1970                1975                1980
Arg Pro Trp Arg Val Val Asp Gly His Leu Asn Leu Pro Val Cys Lys 
 1985                1990                1995                2000
Gly Met Met Glu Ala Met Leu Tyr His Ile Met Thr Arg Pro Gly Ile 
                 2005                2010                2015
Pro Glu Ser Ser Leu Leu Arg His Tyr Gln Gly Val Leu Gln Pro Val 
             2020                2025                2030
Ala Val Leu Glu Leu Leu Gln Gly Leu Glu Ser Leu Gly Cys Ile Arg 
         2035                2040                2045
Lys Arg Trp Leu Arg Lys Pro Arg Pro Val Ser Leu Phe Ser Thr Pro 
     2050                2055                2060
Val Val Glu Glu Val Glu Val Pro Ser Ser Leu Asp Glu Ser Pro Met 
 2065                2070                2075                2080
Ala Phe Tyr Glu Pro Thr Leu Asp Cys Thr Leu Arg Leu Gly Arg Val 
                 2085                2090                2095
Phe Pro His Glu Val Asn Trp Asn Lys Trp Ile His Leu Ter 
             2100                2105                2110



<210> 3161
<211> 3808
<212> DNA
<213> Rattus norvegicus
<308> L29281
<400> 3161

gaactagcc  gacctggac  tgcccggca  aagcgacag  ggtcggagg  cgacgagat  60
ttaggggca  cacctgaag  acaattcga  tcctgcgcc  gggcacggg  cattgtccg  120
atccagaaa  tcggtcacc  gggaagaaa  atggccagt  atacaccag  tttctacgt  180
gacaaactt  acaaatact  ccagataca  aaagtaaag  ttatatata  agaaatttc  240
gttacagga  ctccacacg  cagaaggtt  acatttcaa  ttataatag  agagaggga  300
tttccagaa  gtgaaggta  atcaaagca  gaggcgaaa  ataatgctg  caaattagc  360
gtcgaaata  ttgataatg  aaacaaggt  gatagtcac  cggatgctt  tgaacaagg  420
ttaatagag  ggaactaca  tggccttgt  aattctttt  cccagaagg  aaatctgcc  480
gtaaatttt  aactgtgtg  ccccgactc  caattgcct  acagattta  ttgtaaatg  540
aaaatcggg  agactacgt  tggtactgg  ttcggtgct  acaaaaagg  ggcaaagca  600
ttggctgcc  aaaatgcgt  tcagaagct  tcagagaaa  gcccatcga  aactggctt  660
gtcacatct  tatccagtg  cttttccag  agctcgtct  taacaagta  ctctgcttc  720
cagtcagca  ctggaaggg  tttcgagga  atatttatg  atggtctca  agaaaaaag  780
aaatcagga  taaaagtgc  atctgatga  gtgctaaga  ataaatata  cttggacga  840
aggtttagc  aagattttg  agacataga  gaaattggc  cgggtggat  tggccaagt  900
ttcaaagca  aacacagaa  cgatggaaa  acgtatgct  ttaagcgca  tacatataa  960
accaagaag  caaagcgtg  agtacaagc  ctagcagaa  tcaatcacg  caacattgt  1020
caataccga  tttgttggg  gggagagga  tatgactat  atcccgaga  cagcacaaa  1080
ggtgacaca  gtcgataca  gacccggtg  ctctttatc  aaatggaat  ctgtgataa  1140
ggaactctg  agcagtggt  ggaaaagag  aatcggagt  aagaggaca  ggctttggt  1200
ttggagtta  ttgaacaaa  agtgacagg  gtggattat  tacactcga  aggtttaat  1260
catagagac  ttaagccag  taatatatt  ttagtggat  aaaaacaca  taagatcgg  1320
gactttggc  ttgcaacag  cctggaaaa  gatggaaat  ctcgaacaa  gtatacagg  1380
actcctcaa  acatgagtc  agaacaaaa  tcatcgtta  tggaatatg  aaaggaagt  1440
gacatcttt  ctttgggcc  tattctagc  gaacttctt  acatatgca  aactgattc  1500
gagaaaata  agtttttcc  acttctaag  aatggcatc  tctccgatg  tattttcga  1560
aacaaggaa  aaagccttc  acagaaatt  ctctcaagt  aacccaggg  acgacccaa  1620
acgtctgaa  tcctgaaga  tttggctga  tggaagaac  tctcggaga  aaagaaaag  1680
aacacgtgt  agggctttt  actgcagtc  gaagtggaa  gtcagagaa  aatgaactt  1740
ttctcttaa  actctccca  acaggtttt  gtaagggtg  cccaaagac  ttgtattta  1800
cggctatga  caagtatgc  cgtttcctc  attgttaat  gtcggacct  tggctggct  1860
gccaaatat  gaaatgttt  tttctttct  gtctgcccg  agagaaagc  aagccgcgg  1920
ggagaaggt  acttaaccc  caatgctaa  tgaaggcct  aggcttttg  catactaaa  1980
agctggcag  cagagctgg  agagaagaa  ctgcagaca  gcaggcaga  acacaaaga  2040
atggactag  atgaaacag  aaggtagag  gattgagag  cagagccac  tggagagac  2100
aaatggcag  gtagtaggc  taagttaga  gagctaact  agagactgc  ccagaaaac  2160
ggccaacag  cttatacac  gatgtctca  tgtctatca  taaactcca  gcaggatca  2220
tgaaggccc  acaataggt  tttttttct  gttacttca  aaacaatct  acaaagtta  2280
tttcttgag  gttccatat  tgtattgta  cctgatcac  ctccaaacc  tctgctgtt  2340
atgccttat  atgtgaact  tacctctga  cgtgggagt  caaattgtc  atctgctcc  2400
taacgttac  tctcatagg  agtttagtc  ttgtgatga  aaaagtaat  aaatggtac  2460
agaaatggg  ttttgtcgc  ataaaccta  tgtgcggtt  cttggactt  caggactgg  2520
ttgtgggaa  aatgtggaa  agtttgaag  agcaggcta  agaagtcct  agatggtat  2580
cgtcaatct  aattctggt  gctcagaag  ctttgccaa  aaggaaccc  ttgggaatt  2640
gactagatg  caggacatt  gtgtacaag  caaaagact  gtgagggaa  tttcaagac  2700
ttcagactg  ggcatggtg  ttatctcct  ctcatagct  gaattatag  gcaaattag  2760
aaggagtga  gggtaagaa  tgagagaac  aagatctgg  aatgagtgc  ttcaaagac  2820
aggtcggtg  aaagctgtt  aagcgatta  tgcactgag  gaagccatg  actttccat  2880
gctgccatt  taggaacaa  actacagcc  cgggcggct  cacagcatg  aaagtaaaa  2940
ccctttaaa  gtctttcgt  tcaaaagtt  cagcaggtg  cacagccac  ccagtggag  3000
ctgtgtgac  ggaagctct  gtgcttcgt  tctatgcag  acagaggcc  gtgcctgga  3060
tggcttgtc  tcctggagg  cctggcagt  tccctgcaa  aagatggtg  ccagggtct  3120
tgctttcag  ggaattgcc  tctgtgttc  agccttggt  atcttagcg  ttttaagcc  3180
gtcaacaat  tctgatttt  ggaatatag  agggtgggc  gatgatcat  tatctttag  3240
tgtctcagg  actgaaata  ataaatgtc  cacaccatc  tggtcctga  gaactcaat  3300
gctgcaatg  attcaactg  tgtatccat  agttcccag  aaataggag  gaaattaat  3360
gcagttact  agaacatga  tgttccaga  aaatctttc  ccccttttg  gaaagtttt  3420
tttagcatg  ttcagaata  taatgattc  tttaaaaaa  atcatagac  acttccaac  3480
agttgaaca  acttaacag  gttaactat  gttactttt  cttccttac  attctgagg  3540
gccataaat  taatagagt  taaacttta  taaaacaaa  gtaaatgat  aatacatac  3600
tggtgccca  cagtctggc  gtataactg  agttttcta  actattgtt  tcagctgag  3660
attgttttc  agactgtat  ttccgcttt  ctccttgca  gggacattt  gtgaggaga  3720
gaataagag  tagatgatt  ccaattatg  tgtatctgt  ctaactgtt  aagtctatg  3780
caaaaagta  agcttttta  aacaacac  3808



<210> 3162
<211> 514
<212> PRT
<213> Rattus norvegicus
<308> L29281
<400> 3162

Met Ala Ser Asp Thr Pro Gly Phe Tyr Val Asp Lys Leu Asn Lys Tyr 
  1               5                  10                  15
Ser Gln Ile His Lys Val Lys Ile Ile Tyr Lys Glu Ile Ser Val Thr 
             20                  25                  30
Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Glu Glu 
         35                  40                  45
Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Gln Glu Ala Lys Asn 
     50                  55                  60
Asn Ala Ala Lys Leu Ala Val Glu Ile Leu Asp Asn Glu Asn Lys Val 
 65                  70                  75                  80
Asp Ser His Thr Asp Ala Ser Glu Gln Gly Leu Ile Glu Gly Asn Tyr 
                 85                  90                  95
Ile Gly Leu Val Asn Ser Phe Ala Gln Lys Glu Asn Leu Pro Val Asn 
             100                105                110
Phe Glu Leu Cys Asp Pro Asp Ser Gln Leu Pro His Arg Phe Ile Cys 
         115                120                125
Lys Cys Lys Ile Gly Gln Thr Thr Tyr Gly Thr Gly Phe Gly Ala Asn 
     130                135                140
Lys Lys Glu Ala Lys Gln Leu Ala Ala Lys Asn Ala Tyr Gln Lys Leu 
 145                150                155                160
Ser Glu Lys Ser Pro Ser Lys Thr Gly Phe Val Thr Ser Leu Ser Ser 
                 165                170                175
Asp Phe Ser Ser Ser Ser Ser Ile Thr Ser Asn Ser Ala Ser Gln Ser 
             180                185                190
Ala Ser Gly Arg Asp Phe Glu Asp Ile Phe Met Asn Gly Leu Arg Glu 
         195                200                205
Lys Arg Lys Ser Gly Val Lys Val Pro Ser Asp Asp Val Leu Arg Asn 
     210                215                220
Lys Tyr Thr Leu Asp Asp Arg Phe Ser Lys Asp Phe Glu Asp Ile Glu 
 225                230                235                240
Glu Ile Gly Ser Gly Gly Phe Gly Gln Val Phe Lys Ala Lys His Arg 
                 245                250                255
Ile Asp Gly Lys Thr Tyr Ala Ile Lys Arg Ile Thr Tyr Asn Thr Lys 
             260                265                270
Lys Ala Lys Arg Glu Val Gln Ala Leu Ala Glu Leu Asn His Ala Asn 
         275                280                285
Ile Val Gln Tyr Arg Val Cys Trp Glu Gly Glu Asp Tyr Asp Tyr Asp 
     290                295                300
Pro Glu Asn Ser Thr Asn Gly Asp Thr Ser Arg Tyr Lys Thr Arg Cys 
 305                310                315                320
Leu Phe Ile Gln Met Glu Phe Cys Asp Lys Gly Thr Leu Gln Gln Trp 
                 325                330                335
Leu Glu Lys Arg Asn Arg Ser Gln Glu Asp Lys Ala Leu Val Leu Glu 
             340                345                350
Leu Phe Glu Gln Ile Val Thr Gly Val Asp Tyr Ile His Ser Lys Gly 
         355                360                365
Leu Ile His Arg Asp Leu Lys Pro Gly Asn Ile Phe Leu Val Asp Glu 
     370                375                380
Lys His Ile Lys Ile Gly Asp Phe Gly Leu Ala Thr Ala Leu Glu Asn 
 385                390                395                400
Asp Gly Asn Pro Arg Thr Lys Tyr Thr Gly Thr Pro Gln Tyr Met Ser 
                 405                410                415
Pro Glu Gln Lys Ser Ser Leu Val Glu Tyr Gly Lys Glu Val Asp Ile 
             420                425                430
Phe Ala Leu Gly Leu Ile Leu Ala Glu Leu Leu His Ile Cys Lys Thr 
         435                440                445
Asp Ser Glu Lys Ile Glu Phe Phe Gln Leu Leu Arg Asn Gly Ile Phe 
     450                455                460
Ser Asp Asp Ile Phe Asp Asn Lys Glu Lys Ser Leu Leu Gln Lys Leu 
 465                470                475                480
Leu Ser Ser Lys Pro Arg Glu Arg Pro Asn Thr Ser Glu Ile Leu Lys 
                 485                490                495
Thr Leu Ala Glu Trp Lys Asn Ile Ser Glu Lys Lys Lys Arg Asn Thr 
             500                505                510
Cys Ter 
         515



<210> 3163
<211> 2562
<212> DNA
<213> Homo sapiens
<308> M35663
<400> 3163

cagtttctg  agcaaattc  gtttgcctt  ctggatttg  aaattgtaa  gacctcaaa  60
ctttagcag  tcttccatc  gactcaggt  tgcttctct  gcggtcttc  gaatcaaca  120
ccacacttc  gtgattatc  gcgtgcatt  tggacaaag  ttccaacca  gatacggga  180
gaagaaatg  ctggtgatc  ttcagcagg  ttcttcatg  aggaactta  tacataccg  240
cagaagcag  gagtagtac  taaatatca  gaactgcct  attcaggac  tccacatga  300
aggaggttt  catttcaag  tataataga  ggaagagaa  ttccagaag  tgaaggtag  360
tcaaagaag  aagcaaaaa  tgccgcagc  aaattagct  ttgagatac  taataagga  420
aagaaggca  ttagtcctt  attattgac  acaacgaat  cttcagaag  attatccat  480
gggaattac  taggcctta  caatagaat  gcccagaag  aaagactaa  tgtaaatta  540
gaacagtgt  catcggggg  gcatgggcc  gaaggattt  attataaat  caaaatggg  600
cagaaagaa  atagtattg  tacaggttc  actaaacag  aagcaaaac  attggccgc  660
aaacttgca  atcttcaga  attatcaga  gaaacctca  tgaaatctg  ctacctgtc  720
tctggttct  ttgctacta  gtgtgagtc  caaagcaac  ctttagtga  cagcacact  780
gcttctgaa  catcatctg  aggtgactt  tcagcagat  catcagaga  aaattctaa  840
agtgacagt  taaacagtt  ttcgttgct  atgaatggt  tcagaaata  tcaaaggaa  900
gcaaaaaga  ctttggcac  cagatttga  cttcctgac  tgaaagaaa  aaagtatac  960
gtggacaag  ggtttggca  ggattttaa  gaaatagaa  taattggct  aggtggatt  1020
ggccaagtt  tcaaagcaa  acacagaat  gacggaaag  cttacgtta  taaacgtgt  1080
aaatataat  acgagaagg  ggagcgtga  gtaaaagca  tggcaaaac  tgatcatgt  1140
aatattgtt  actacaatg  ctgttggga  ggatttgat  atgatcctg  gaccagtga  1200
gattctctt  agagcagtg  ttatgatcc  gagaacagc  aaaatagtt  aaggtcaaa  1260
actaagtgc  ttttcatcc  aatggaatt  tgtgataaa  ggaccttgg  acaatggat  1320
gaaaaaaga  gaggcgaga  actagacaa  gttttggct  tggaactct  tgaacaaat  1380
acaaaaggg  tggattata  acattcaaa  aaattaatt  atagagatc  taagccaag  1440
aatatattc  tagtagata  aaaacaagt  aagattgga  actttggac  tgtaacatc  1500
ctgaaaaat  atggaaagc  aacaaggag  aagggaact  tgcgataca  gagcccaga  1560
cagatttct  cgcaagact  tggaaagga  gtggacctc  acgctttgg  gctaattct  1620
gctgaactt  ttcatgtat  tgacactgc  tttgaaaca  caaagtttt  cacagacct  1680
cgggatggc  tcatctcag  tatatttga  aaaaaagaa  aaactcttc  acagaaatt  1740
ctctcaaag  aacctgagg  tcgacctaa  acatctgaa  tactaagga  cttgactgt  1800
tggaagaaa  gcccagaga  aaatgaacg  cacacatgt  agagccctt  tgaaaaagt  1860
tcctgcttc  gatatgcag  tttccttaa  ttatctaaa  tctgctagg  aatatcaat  1920
gatatttac  ttttatttt  atgtttcct  taatttttt  ctattttta  taatctttc  1980
gcagaaaca  aaaggtttt  ttctttttg  ttcaaaaac  ttcttacat  ttacttttt  2040
ctggctcat  tctttattt  ttttttttt  ttttaaaga  agagtctcg  tctgttgcc  2100
aggctggag  gcaatgaca  agtcttggc  cactgcaac  tctgcctct  gggttcaag  2160
gattctcct  cctcagcct  ctgagtagc  ggattacag  catgtgcca  ccacccaac  2220
aatttttgt  tttttaata  agacagggt  tcaccatgt  ggccaggct  gtctcaaac  2280
cctgacctc  agtaatcca  ctgcctcgg  ctcccaaag  gctgggatt  cagggatga  2340
ccaccgcgc  cagcctcat  tctttgttc  aaagatgga  aaaccaccc  caaattttc  2400
ttttatact  ttaatgaat  aatcaattc  tatctattt  ttaaatttc  accgctttt  2460
ggccaaaaa  atgtaagat  gttctctgc  tcacatagc  tacaagcca  ctggagaaa  2520
atggtactc  ttaaaaaaa  aaaaaaaaa  tgatgtaca  cc  2562



<210> 3164
<211> 551
<212> PRT
<213> Homo sapiens
<308> P19525
<400> 3164

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
  1               5                  10                  15
Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
             20                  25                  30
Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
         35                  40                  45
Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
     50                  55                  60
Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
 65                  70                  75                  80
Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                 85                  90                  95
Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
             100                105                110
Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro 
         115                120                125
Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile 
     130                135                140
Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
 145                150                155                160
Ala Tyr Leu Gln Ile Leu Ser Glu Glu Thr Ser Val Lys Ser Asp Tyr 
                 165                170                175
Leu Ser Ser Gly Ser Phe Ala Thr Thr Cys Glu Ser Gln Ser Asn Ser 
             180                185                190
Leu Val Thr Ser Thr Leu Ala Ser Glu Ser Ser Ser Glu Gly Asp Phe 
         195                200                205
Ser Ala Asp Thr Ser Glu Ile Asn Ser Asn Ser Asp Ser Leu Asn Ser 
     210                215                220
Ser Ser Leu Leu Met Asn Gly Leu Arg Asn Asn Gln Arg Lys Ala Lys 
 225                230                235                240
Arg Ser Leu Ala Pro Arg Phe Asp Leu Pro Asp Met Lys Glu Thr Lys 
                 245                250                255
Tyr Thr Val Asp Lys Arg Phe Gly Met Asp Phe Lys Glu Ile Glu Leu 
             260                265                270
Ile Gly Ser Gly Gly Phe Gly Gln Val Phe Lys Ala Lys His Arg Ile 
         275                280                285
Asp Gly Lys Thr Tyr Val Ile Lys Arg Val Lys Tyr Asn Asn Glu Lys 
     290                295                300
Ala Glu Arg Glu Val Lys Ala Leu Ala Lys Leu Asp His Val Asn Ile 
 305                310                315                320
Val His Tyr Asn Gly Cys Trp Asp Gly Phe Asp Tyr Asp Pro Glu Thr 
                 325                330                335
Ser Asp Asp Ser Leu Glu Ser Ser Asp Tyr Asp Pro Glu Asn Ser Lys 
             340                345                350
Asn Ser Ser Arg Ser Lys Thr Lys Cys Leu Phe Ile Gln Met Glu Phe 
         355                360                365
Cys Asp Lys Gly Thr Leu Glu Gln Trp Ile Glu Lys Arg Arg Gly Glu 
     370                375                380
Lys Leu Asp Lys Val Leu Ala Leu Glu Leu Phe Glu Gln Ile Thr Lys 
 385                390                395                400
Gly Val Asp Tyr Ile His Ser Lys Lys Leu Ile His Arg Asp Leu Lys 
                 405                410                415
Pro Ser Asn Ile Phe Leu Val Asp Thr Lys Gln Val Lys Ile Gly Asp 
             420                425                430
Phe Gly Leu Val Thr Ser Leu Lys Asn Asp Gly Lys Arg Thr Arg Ser 
         435                440                445
Lys Gly Thr Leu Arg Tyr Met Ser Pro Glu Gln Ile Ser Ser Gln Asp 
     450                455                460
Tyr Gly Lys Glu Val Asp Leu Tyr Ala Leu Gly Leu Ile Leu Ala Glu 
 465                470                475                480
Leu Leu His Val Cys Asp Thr Ala Phe Glu Thr Ser Lys Phe Phe Thr 
                 485                490                495
Asp Leu Arg Asp Gly Ile Ile Ser Asp Ile Phe Asp Lys Lys Glu Lys 
             500                505                510
Thr Leu Leu Gln Lys Leu Leu Ser Lys Lys Pro Glu Asp Arg Pro Asn 
         515                520                525
Thr Ser Glu Ile Leu Arg Thr Leu Thr Val Trp Lys Lys Ser Pro Glu 
     530                535                540
Lys Asn Glu Arg His Thr Cys 
 545                550



<210> 3165
<211> 471
<212> DNA
<213> Rattus norvegicus
<308> L29573
<400> 3165

tacagggat  ccttgctga  cagcaccat  aactgtgtt  ccagtttta  ttctggatt  60
gccattttc  ccatccttg  ttacatggc  catgaacat  aagtcaaga  tgaggatgt  120
gccactgaa  gagctggcc  tgtatttgt  ctgtatcca  aagccattt  tactctgtc  180
ggatccacg  tctgggctg  cctgttctt  ctgatgctc  tggctctgg  gctagatag  240
tcaatggga  gcatggagg  agtcatcac  ggactggct  atgacttcc  ggtcctgaa  300
cgacaccga  aactcttca  atgtgctgt  accctcggt  cctttcttc  ggccatgtt  360
tgcataacg  agggaggga  ttacgtcct  actctgctg  acaccttcg  ggcaggcac  420
tccattctc  ttgccgtgc  catggaggc  attggagtt  cctggtttt  t  471



<210> 3166
<211> 1983
<212> DNA
<213> Homo sapiens
<308> M65105
<400> 3166

gccggacac  gcctcggcg  gcccccagg  ccggtaaag  tcctctcgc  agccgcatc  60
atgcttctg  cgcggatga  cccgcaggt  cagcccgag  acaacgggg  ggacacggg  120
ccagagcag  cccttcggg  gcgcaaaac  gcggagctg  tggtggtga  ggagcgcaa  180
ggcgtccag  gcctgctgg  gccccgcga  ggcgacgcg  agccccggg  gacctgggg  240
aagaagatc  acttcctgc  gtccgtagt  ggcttcgca  tggacctgg  caacgtgtg  300
cgcttcccc  acctctgct  caagaacgg  ggcggtgcc  tcttgatcc  gtacacact  360
ttccttatc  tcgcgggga  gcccctgtt  tacatggag  tggctctgg  acagtacaa  420
cgggagggg  ctgccaccg  ttggaaaat  tgcccattc  tcaaaggcg  tggctatgc  480
gtcatcctg  tcgccctgt  cgttggctt  tactacaac  tcatcatcg  ctggtcact  540
tactacctc  tctcctcct  caccctcaa  ctgccctgg  ccgactgtg  ccacacctg  600
aacagcccc  actgtaccg  ccccaagct  ctcaatggc  ccgtgcttg  caaccacac  660
aagtactcc  agtacaagt  cacgccggc  gccgagttt  atgagcgtg  tgtcctgca  720
cttcacgag  gcagcggga  tcatgacat  ggcctgccc  agtggcagc  cttgctctg  780
ctgatggtc  tcgtcatcg  cttgtattt  agcctctgg  aaggggtga  gacatcagg  840
aaggtggtg  ggatcacag  cacgctgcc  tacttcgtg  tgttcgtgc  cctggtcca  900
ggcgtcacg  tgcccggag  ctccaatgg  atcaatgcc  acctgcaca  cgacttcta  960
cgcttgaaa  aggccacgg  atggattga  gccgcaact  agatatttt  ttccttggg  1020
gctggattt  gagtattga  tgcatttgc  agttacaac  aatttgaca  caactgtta  1080
agggatgcc  tgctgacca  cagcatcaa  tgtatcacc  gcttcgtct  tgggttcgc  1140
atcttctcc  tccttggtt  catggccca  gaacacaag  tcaacattg  ggatgtggc  1200
acagaagga  ctggcctag  gttcatcct  tatccagag  ccatttcta  cctgtctgg  1260
tctacattc  gggctgttg  gtttttcgt  atgctcctg  cgctgggcc  tgacagctc  1320
atgggaggc  tggaggctg  catcacggg  ctggcagat  acttccagg  cctgaagcg  1380
caccggaaa  tcttcacat  tggcgtcac  ttcagcact  tccttctcg  cctgttctg  1440
ataaccaag  gtggaattt  cgtcttgac  ctcctggac  cctttgctg  gggcacctc  1500
atccttttt  ctgtcctca  ggaagccat  ggagtttcc  ggttttatg  agtggacag  1560
ttcagcaac  acatccagc  gatgatggg  ttcaggccg  gtctatact  gagactgtg  1620
tggaagttc  tcagtcctg  cttcctcct  ttcgtggtt  tggtcagca  catcaactt  1680
aagccactc  cctacgacg  ctacatctt  ccgccctgg  ccaactggg  ggggtgggg  1740
atcgccctg  cctccatgg  cctggtgcc  atctacgtc  tctataagt  cctcagcac  1800
cagggctct  tttgggaga  actggccta  ggcatcacg  cagagaacg  gcaccacct  1860
gtggctcag  gggacatca  acagttcca  ttgcaacac  ggctggcca  ctgagcctg  1920
ctggaggag  aggaggaac  cccatgcca  tgtccaggt  acaggcatc  gctgctacg  1980
caa  1983



<210> 3167
<211> 617
<212> PRT
<213> Homo sapiens
<308> P23975
<400> 3167

Met Leu Leu Ala Arg Met Asn Pro Gln Val Gln Pro Glu Asn Asn Gly 
  1               5                  10                  15
Ala Asp Thr Gly Pro Glu Gln Pro Leu Arg Ala Arg Lys Thr Ala Glu 
             20                  25                  30
Leu Leu Val Val Lys Glu Arg Asn Gly Val Gln Cys Leu Leu Ala Pro 
         35                  40                  45
Arg Asp Gly Asp Ala Gln Pro Arg Glu Thr Trp Gly Lys Lys Ile Asp 
     50                  55                  60
Phe Leu Leu Ser Val Val Gly Phe Ala Val Asp Leu Ala Asn Val Trp 
 65                  70                  75                  80
Arg Phe Pro Tyr Leu Cys Tyr Lys Asn Gly Gly Gly Ala Phe Leu Ile 
                 85                  90                  95
Pro Tyr Thr Leu Phe Leu Ile Ile Ala Gly Met Pro Leu Phe Tyr Met 
             100                105                110
Glu Leu Ala Leu Gly Gln Tyr Asn Arg Glu Gly Ala Ala Thr Val Trp 
         115                120                125
Lys Ile Cys Pro Phe Phe Lys Gly Val Gly Tyr Ala Val Ile Leu Ile 
     130                135                140
Ala Leu Tyr Val Gly Phe Tyr Tyr Asn Val Ile Ile Ala Trp Ser Leu 
 145                150                155                160
Tyr Tyr Leu Phe Ser Ser Phe Thr Leu Asn Leu Pro Trp Thr Asp Cys 
                 165                170                175
Gly His Thr Trp Asn Ser Pro Asn Cys Thr Asp Pro Lys Leu Leu Asn 
             180                185                190
Gly Ser Val Leu Gly Asn His Thr Lys Tyr Ser Lys Tyr Lys Phe Thr 
         195                200                205
Pro Ala Ala Glu Phe Tyr Glu Arg Gly Val Leu His Leu His Glu Ser 
     210                215                220
Ser Gly Ile His Asp Ile Gly Leu Pro Gln Trp Gln Leu Leu Leu Cys 
 225                230                235                240
Leu Met Val Val Val Ile Val Leu Tyr Phe Ser Leu Trp Lys Gly Val 
                 245                250                255
Lys Thr Ser Gly Lys Val Val Trp Ile Thr Ala Thr Leu Pro Tyr Phe 
             260                265                270
Val Leu Phe Val Leu Leu Val His Gly Val Thr Leu Pro Gly Ala Ser 
         275                280                285
Asn Gly Ile Asn Ala Tyr Leu His Ile Asp Phe Tyr Arg Leu Lys Glu 
     290                295                300
Ala Thr Val Trp Ile Asp Ala Ala Thr Gln Ile Phe Phe Ser Leu Gly 
 305                310                315                320
Ala Gly Phe Gly Val Leu Ile Ala Phe Ala Ser Tyr Asn Lys Phe Asp 
                 325                330                335
Asn Asn Cys Tyr Arg Asp Ala Leu Leu Thr Ser Ser Ile Asn Cys Ile 
             340                345                350
Thr Ser Phe Val Ser Gly Phe Ala Ile Phe Ser Ile Leu Gly Tyr Met 
         355                360                365
Ala His Glu His Lys Val Asn Ile Glu Asp Val Ala Thr Glu Gly Ala 
     370                375                380
Gly Leu Val Phe Ile Leu Tyr Pro Glu Ala Ile Ser Thr Leu Ser Gly 
 385                390                395                400
Ser Thr Phe Trp Ala Val Val Phe Phe Val Met Leu Leu Ala Leu Gly 
                 405                410                415
Leu Asp Ser Ser Met Gly Gly Met Glu Ala Val Ile Thr Gly Leu Ala 
             420                425                430
Asp Asp Phe Gln Val Leu Lys Arg His Arg Lys Leu Phe Thr Phe Gly 
         435                440                445
Val Thr Phe Ser Thr Phe Leu Leu Ala Leu Phe Cys Ile Thr Lys Gly 
     450                455                460
Gly Ile Tyr Val Leu Thr Leu Leu Asp Thr Phe Ala Ala Gly Thr Ser 
 465                470                475                480
Ile Leu Phe Ala Val Leu Met Glu Ala Ile Gly Val Ser Trp Phe Tyr 
                 485                490                495
Gly Val Asp Arg Phe Ser Asn Asp Ile Gln Gln Met Met Gly Phe Arg 
             500                505                510
Pro Gly Leu Tyr Trp Arg Leu Cys Trp Lys Phe Val Ser Pro Ala Phe 
         515                520                525
Leu Leu Phe Val Val Val Val Ser Ile Ile Asn Phe Lys Pro Leu Thr 
     530                535                540
Tyr Asp Asp Tyr Ile Phe Pro Pro Trp Ala Asn Trp Val Gly Trp Gly 
 545                550                555                560
Ile Ala Leu Ser Ser Met Val Leu Val Pro Ile Tyr Val Ile Tyr Lys 
                 565                570                575
Phe Leu Ser Thr Gln Gly Ser Leu Trp Glu Arg Leu Ala Tyr Gly Ile 
             580                585                590
Thr Pro Glu Asn Glu His His Leu Val Ala Gln Arg Asp Ile Arg Gln 
         595                600                605
Phe Gln Leu Gln His Trp Leu Ala Ile 
     610                615



<210> 3168
<211> 2106
<212> DNA
<213> Rattus norvegicus
<308> L31619
<400> 3168

gccgtgctg  cgctccagc  acatgtgcg  cgggcgggg  ggcatctgg  tggctctgg  60
cgcggcgct  ctgcacgtg  ccctgcaag  cgagttcca  aggaggctg  acaaggagc  120
ggtcaagaa  tacaacccg  tggagaggc  ggtggccaa  gactcgcag  cgctcaccg  180
gtacttctc  ctgagtctc  tgcagatca  ggatgtgga  gagaagaac  aagttttaa  240
caccaacat  tggctacaa  tgtcttgga  agatcacta  ttgcagtgg  acatgtctg  300
gtaccccgg  gtgaagaat  ttcgttttc  agatggcca  atttggaaa  cagacattc  360
cctctataa  agtgctgat  agcgctttg  tgccacgtt  cacaccaat  ttttggtga  420
tgcatctgg  cattgccag  atctccctc  aggcatatt  aagagctcc  gctacattg  480
cgttcgctg  ttccctttt  atgtgcagc  gtgcaaact  aagtttggg  cctggtcct  540
tggagggtg  tcactggac  tgcaaatgc  agaggcaga  atcagcagc  atatcccca  600
cggagaatg  gatctcatg  gaatccctg  caaaaggaa  gagaagttc  atgagtgct  660
caaagagcc  tacccagat  tcacctaca  agtaaccat  cgccgtagg  cactctact  720
tggcctcaa  ctgctcatc  cttgtgtac  catttcagc  ctggctctg  tggtattct  780
gctgcctgc  gactctgga  agaaaatct  tcttggaat  actgtctta  tttctctga  840
tgtcttcat  ctgcttgtg  ctgagatca  gccagcaac  tctgattct  tgcccttga  900
agcacaata  ttcgccagc  ccatgatca  cgtgggcct  tctgtagtg  tgacagtga  960
tgtgctgag  tatcaccac  atgaccctg  tggtggcaa  atgcctaag  ggaccagaa  1020
cattctcct  aactggtgt  catggtttc  gcgcatgaa  aggcccgga  aggacaagg  1080
gcggccagc  tgtcagcac  agcctcggc  ctgcagcct  gccagtgtg  agctgagtg  1140
aggtgctgg  ccacccacc  gcaatggca  cctgctcta  attggcttc  gaggcctgg  1200
gggcatgca  tgtgcccca  ctccagact  tggggtcgt  tgtggccgt  tggcctgct  1260
cccaacaca  gatgagcac  tcatgcacg  tgcacaccc  tctgatggg  accccgacc  1320
ggccaagat  ctggaggag  tccgctaca  cgccaaccg  ttccgctgc  aggacgaga  1380
tgaggtgat  tgcagtgaa  ggaagtttg  agcctgcgt  gtggaccgc  tgtgcctca  1440
ggccttttc  gtctttacc  tcatctgta  catcggcat  ctcatgtca  ctccaaact  1500
tgtggaggc  gtgtccaaa  actttgctt  atgttatca  gtaggaaat  cgcagataa  1560
aagagaatc  ggagggtga  aattggggt  ctaactcca  agtgtgata  atggaagaa  1620
tctgaggta  ccctgtagc  gtcaatctt  agacttagt  ttctggtta  tttaactga  1680
aagatctca  cagccttct  tttattctt  tctccctta  cactggcat  gccttgtac  1740
cagcagggg  actacgtgg  cgtttgtct  ctctggaca  ccctatagg  tagatctta  1800
tggctcttg  agcccagta  aagcctgtc  tgttggtgg  gcatggaaa  atgccccag  1860
cctgggctc  caagaattc  ctgtctgcc  ttgctatgc  cagacccag  ctgaaacca  1920
tgcagagca  tccccactg  atccaccgc  gcaactgcc  tgaaaaagg  aggcaaata  1980
aaattcaaa  tgcaaactt  tctgctagt  tctctgcta  ttttcctgt  attcaactt  2040
catttctgt  tgtttatct  tctgtctat  tatctatct  tctatctat  tatctatct  2100
tctatc  2106



<210> 3169
<211> 502
<212> PRT
<213> Rattus norvegicus
<308> Q05941
<400> 3169

Met Cys Gly Gly Arg Gly Gly Ile Trp Leu Ala Leu Ala Ala Ala Leu 
  1               5                  10                  15
Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Arg Leu Tyr Lys Glu 
             20                  25                  30
Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
         35                  40                  45
Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
     50                  55                  60
Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
 65                  70                  75                  80
Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Met Ser Glu Tyr Pro Gly 
                 85                  90                  95
Val Lys Asn Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
             100                105                110
Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
         115                120                125
Asn Val Leu Val Asn Ala Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
     130                135                140
Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
 145                150                155                160
Val Gln Gln Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                 165                170                175
Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Ser Tyr Ile Pro 
             180                185                190
Asn Gly Glu Trp Asp Leu Met Gly Ile Pro Gly Lys Arg Asn Glu Lys 
         195                200                205
Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Tyr Thr Val 
     210                215                220
Thr Met Arg Arg Arg Thr Leu Tyr Tyr Gly Leu Asn Leu Leu Ile Pro 
 225                230                235                240
Cys Val Leu Ile Ser Ala Leu Ala Leu Leu Val Phe Leu Leu Pro Ala 
                 245                250                255
Asp Ser Gly Glu Lys Ile Ser Leu Gly Ile Thr Val Leu Leu Ser Leu 
             260                265                270
Thr Val Phe Met Leu Leu Val Ala Glu Ile Met Pro Ala Thr Ser Asp 
         275                280                285
Ser Val Pro Leu Ile Ala Gln Tyr Phe Ala Ser Thr Met Ile Ile Val 
     290                295                300
Gly Leu Ser Val Val Val Thr Val Ile Val Leu Arg Tyr His His His 
 305                310                315                320
Asp Pro Asp Gly Gly Lys Met Pro Lys Trp Thr Arg Ile Ile Leu Leu 
                 325                330                335
Asn Trp Cys Ala Trp Phe Leu Arg Met Lys Arg Pro Gly Glu Asp Lys 
             340                345                350
Val Arg Pro Ala Cys Gln His Lys Pro Arg Arg Cys Ser Leu Ala Ser 
         355                360                365
Val Glu Leu Ser Ala Gly Ala Gly Pro Pro Thr Ser Asn Gly Asn Leu 
     370                375                380
Leu Tyr Ile Gly Phe Arg Gly Leu Glu Gly Met His Cys Ala Pro Thr 
 385                390                395                400
Pro Asp Ser Gly Val Val Cys Gly Arg Leu Ala Cys Ser Pro Thr His 
                 405                410                415
Asp Glu His Leu Met His Gly Ala His Pro Ser Asp Gly Asp Pro Asp 
             420                425                430
Leu Ala Lys Ile Leu Glu Glu Val Arg Tyr Ile Ala Asn Arg Asn Arg 
         435                440                445
Cys Gln Asp Glu Ser Glu Val Ile Cys Ser Glu Trp Lys Phe Ala Ala 
     450                455                460
Cys Val Val Asp Pro Leu Cys Leu Met Ala Phe Ser Val Phe Thr Ile 
 465                470                475                480
Ile Cys Thr Ile Gly Ile Leu Met Ser Ala Pro Asn Phe Val Glu Ala 
                 485                490                495
Val Ser Lys Asp Phe Ala 
             500



<210> 3170
<211> 2087
<212> DNA
<213> Homo sapiens
<308> X70297
<400> 3170

ggcacgagg  gccgagcgg  gaggtgcct  tgtggccgc  cggcaggcc  gggcgacac  60
gagacgtgg  gcgcgccgg  tcgctgcag  tccgggact  aacatgcgc  gctcgccgg  120
aggcgtctg  ctgggcctg  ccgcgtcgc  cctgcacgt  tccctgcaa  gcgagttcc  180
gaggaagct  tacaaggag  tggtcaaga  ctacaatcc  ttggagagg  ccgtggcca  240
tgactcgca  ccactcacc  tctacttct  cctgagcct  ctgcagatc  tggacgtgg  300
tgagaagaa  caagtttta  ccaccaaca  ttggctgca  atgtcttgg  cagatcact  360
tttacagtg  aatgtgtca  aatatccag  ggtgaagac  gttcgtttc  cagatggcc  420
gatttggaa  ccagacatt  ttctctata  cagtgctga  gagcgcttt  acgccacat  480
ccacactaa  gtgttggtg  attcttctg  gcattgcca  tacctgcct  caggcatat  540
caagagttc  tgctacatc  atgtacgct  gtttccctt  gatgtgcag  actgcaaac  600
gaagtttgg  tcctggtct  acggaggct  gtccttgga  ctgcagatg  aggaggcag  660
tatcagtgg  tatatcccc  atggagaat  ggacctagt  ggaatcccc  gcaagagga  720
tgaaaggtt  tatgagtgc  gcaaagagc  ctaccccga  gtcaccttc  cagtgacca  780
gcgccgcag  acactctac  atggcctca  cctgctgat  ccctgtgtg  tcatctccg  840
cctcgccct  ctggtgttc  tgcttcctg  agattccgg  gagaagatt  ccctgggga  900
aacagtctt  ctctctctt  ccgtcttca  gctgctcgt  gctgagatc  tgcccgcaa  960
atccgattc  gtaccattg  tagcccagt  cttcgccag  accatgatc  tcgtgggcc  1020
ctcggtggt  gtgacagtg  tcgtgctgc  gtaccacca  cacgacccc  acgggggca  1080
gatgcccaa  tggaccaga  tcatccttc  gaactggtg  gcgtggttc  tgcgaatga  1140
gaggcccgg  gaggacaag  tgcgcccgg  ctgccagca  aagcagcgg  gctgcagcc  1200
ggccagtgt  gagatgagc  ccgtgggcc  gccgcccgc  agcaacggg  acctgctgt  1260
catcggctt  cgcggcctg  acggcgtgc  ctgtgtccc  acccccgac  ctggggtag  1320
gtgtggccg  atggcctgc  cccccacgc  cgatgagca  ctcctgcac  gcgggcaac  1380
ccccgaggg  gacccggac  tggccaaga  cctggagga  gtccgctac  ttgccaacc  1440
cttccgctg  caggacgaa  gcgaggcgg  ctgcagcga  tggaagttc  ccgcctgtg  1500
ggtggaccg  ctgtgcctc  tggccttct  ggtcttcac  atcatctgc  ccatcggca  1560
cctgatgtc  gctcccaac  tcgtggagg  cgtgtccaa  gactttgcg  aaccacact  1620
gttctgtac  tgtggaaaa  tcacagatg  gcaaggcct  tggcttggc  agatttggg  1680
gtgctaatc  aggacagca  tacacgcca  aactccagt  ttcccttct  gctgtcagt  1740
gtgttgctt  cggtttctt  gttacttta  gtagtagaa  ctcagcact  tgtttcata  1800
tctcagatg  gctgataga  actccttgg  acatccgta  catcggtca  cagggccac  1860
gagtagtca  tttgccatt  gccctcagc  tggaaagcc  ttcggagag  tccccatgg  1920
tcctcacca  cgagacagt  ggttttgca  gtctgcatg  aggtctacc  gaaaattca  1980
catttgctt  ttgcttgtg  acaaaccca  attgaagct  aaataaacc  gactcacta  2040
atcctttcc  ataattgac  ggtggaagg  aaacaaaaa  aaaaaaa  2087



<210> 3171
<211> 502
<212> PRT
<213> Homo sapiens
<308> P36544
<400> 3171

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
  1               5                  10                  15
Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
             20                  25                  30
Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
         35                  40                  45
Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
     50                  55                  60
Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
 65                  70                  75                  80
Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                 85                  90                  95
Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
             100                105                110
Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
         115                120                125
Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
     130                135                140
Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
 145                150                155                160
Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                 165                170                175
Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
             180                185                190
Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
         195                200                205
Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
     210                215                220
Thr Met Arg Arg Arg Thr Leu Tyr Tyr Gly Leu Asn Leu Leu Ile Pro 
 225                230                235                240
Cys Val Leu Ile Ser Ala Leu Ala Leu Leu Val Phe Leu Leu Pro Ala 
                 245                250                255
Asp Ser Gly Glu Lys Ile Ser Leu Gly Ile Thr Val Leu Leu Ser Leu 
             260                265                270
Thr Val Phe Met Leu Leu Val Ala Glu Ile Met Pro Ala Thr Ser Asp 
         275                280                285
Ser Val Pro Leu Ile Ala Gln Tyr Phe Ala Ser Thr Met Ile Ile Val 
     290                295                300
Gly Leu Ser Val Val Val Thr Val Ile Val Leu Gln Tyr His His His 
 305                310                315                320
Asp Pro Asp Gly Gly Lys Met Pro Lys Trp Thr Arg Val Ile Leu Leu 
                 325                330                335
Asn Trp Cys Ala Trp Phe Leu Arg Met Lys Arg Pro Gly Glu Asp Lys 
             340                345                350
Val Arg Pro Ala Cys Gln His Lys Gln Arg Arg Cys Ser Leu Ala Ser 
         355                360                365
Val Glu Met Ser Ala Val Ala Pro Pro Pro Ala Ser Asn Gly Asn Leu 
     370                375                380
Leu Tyr Ile Gly Phe Arg Gly Leu Asp Gly Val His Cys Val Pro Thr 
 385                390                395                400
Pro Asp Ser Gly Val Val Cys Gly Arg Met Ala Cys Ser Pro Thr His 
                 405                410                415
Asp Glu His Leu Leu His Gly Gly Gln Pro Pro Glu Gly Asp Pro Asp 
             420                425                430
Leu Ala Lys Ile Leu Glu Glu Val Arg Tyr Ile Ala Asn Arg Phe Arg 
         435                440                445
Cys Gln Asp Glu Ser Glu Ala Val Cys Ser Glu Trp Lys Phe Ala Ala 
     450                455                460
Cys Val Val Asp Arg Leu Cys Leu Met Ala Phe Ser Val Phe Thr Ile 
 465                470                475                480
Ile Cys Thr Ile Gly Ile Leu Met Ser Ala Pro Asn Phe Val Glu Ala 
                 485                490                495
Val Ser Lys Asp Phe Ala 
             500



<210> 3172
<211> 1858
<212> DNA
<213> Rattus norvegicus
<308> L31621
<400> 3172

ggtgccagc  cttgagtag  tgtgcttcg  tggtcagca  cagagtgtc  ccctccctg  60
ctatcgggt  ttagacatg  gtgttgtgc  gctcccgcc  ccgctgtcc  tgctgatgc  120
ggtgctgat  ctgctgcca  cggccagtg  ctcagaagc  gagcaccgc  tgttccagt  180
cctgttcga  gattacaac  agatcatcc  gccagtggc  aatgtgtcc  atccagtca  240
catccagtt  gaggtgtcc  tgtctcagc  ggtgaaggt  gatgaagta  accagatca  300
ggaaaccaa  ctgtggctg  agcaaatct  gaatgacta  aagctgaaa  ggaaaccct  360
tgactacca  ggggtggag  tcatgcgtg  tcctgcaga  aagatctgg  aaccagaca  420
cgtactgta  aacaacgct  atggggatt  ccaggtgga  gacaagacc  aagctctac  480
caagtacac  ggagaagtg  cttggatcc  gccggccat  tttaagagc  catgcaaaa  540
cgacgtgac  tacttccca  tcgactacc  aaactgcac  atgaagttc  gctcctggt  600
ctacgacaa  gcaaagatc  acctggtcc  catcggctc  tccatgaac  tcaaggact  660
ctgggagag  ggcgagtgg  ctatcatta  agccccggg  tacaaacat  aaatcaagt  720
caactgctg  gaggagatc  accaagaca  cacgtactc  ctgtacatc  gtcgcctgc  780
gctgttcta  accatcaac  tcatcatcc  ctgcctgct  atctccttc  tcactgtgc  840
tgtcttcta  ctgccctcc  actgtgggg  gaaggtgac  ctctgcatc  ctgtgctcc  900
ctccctgac  gtctttctc  tggtgatca  cgagaccat  ccttccacc  cgctggtca  960
ccccctgat  ggggagtac  tcctcttca  tatgatttt  gtcaccttg  ccattgtca  1020
cacagtctt  gtgctcaat  tgcactata  aactccaac  acacacacc  tgcccactt  1080
ggtcaaggc  gtgttcttg  acctgctcc  cagggtcat  tttatgact  ggccgacca  1140
tggtgaggg  gacactcct  agacgagga  cttctacgg  gctgagctc  caaacctga  1200
ctgcttcag  cgtgcagac  ccaaaagct  caaggaagg  tacccctgc  aagatggga  1260
ctgtggcta  tgccaccac  gtagggtaa  aatctcaaa  ttcagtgcc  acctcacaa  1320
aagctccag  tctgagtct  tcaacgctg  gttgtccct  tctgccctg  caccagaaa  1380
caaagaagc  atccaaagt  tgaagtaca  tgccgaaaa  atgaaagca  agaatgtag  1440
caaagagat  caagatgat  ggaagtacg  tgccatggt  attgatcgc  tctttctct  1500
ggttttcat  ctggtgtgc  ttttaggaa  ggcgggatt  tttctgcaa  ccttgatgg  1560
cagagatga  acatagact  tgcactgtt  atcgaggct  acctgtgct  acgcaaggg  1620
ccacttcct  aatagcact  tactttatc  gatcactgg  ttggagttt  ctatttcaa  1680
ggttatttt  aactcatct  gatttttcg  aaaaaagaa  tgtgggaga  aaatgtcta  1740
ttatttatc  tgggtaaat  aacatttca  tacccctgt  attgaaact  taggtagaa  1800
aattttctg  tcataaata  taactccat  agtgcagga  ctccataaa  tcatttct  1858



<210> 3173
<211> 499
<212> PRT
<213> Rattus norvegicus
<308> P04757
<400> 3173

Met Gly Val Val Leu Leu Pro Pro Pro Leu Ser Met Leu Met Leu Val 
  1               5                  10                  15
Leu Met Leu Leu Pro Ala Ala Ser Ala Ser Glu Ala Glu His Arg Leu 
             20                  25                  30
Phe Gln Tyr Leu Phe Glu Asp Tyr Asn Glu Ile Ile Arg Pro Val Ala 
         35                  40                  45
Asn Val Ser His Pro Val Ile Ile Gln Phe Glu Val Ser Met Ser Gln 
     50                  55                  60
Leu Val Lys Val Asp Glu Val Asn Gln Ile Met Glu Thr Asn Leu Trp 
 65                  70                  75                  80
Leu Lys Gln Ile Trp Asn Asp Tyr Lys Leu Lys Trp Lys Pro Ser Asp 
                 85                  90                  95
Tyr Gln Gly Val Glu Phe Met Arg Val Pro Ala Glu Lys Ile Trp Lys 
             100                105                110
Pro Asp Ile Val Leu Tyr Asn Asn Ala Asp Gly Asp Phe Gln Val Asp 
         115                120                125
Asp Lys Thr Lys Ala Leu Leu Lys Tyr Thr Gly Glu Val Thr Trp Ile 
     130                135                140
Pro Pro Ala Ile Phe Lys Ser Ser Cys Lys Ile Asp Val Thr Tyr Phe 
 145                150                155                160
Pro Phe Asp Tyr Gln Asn Cys Thr Met Lys Phe Gly Ser Trp Ser Tyr 
                 165                170                175
Asp Lys Ala Lys Ile Asp Leu Val Leu Ile Gly Ser Ser Met Asn Leu 
             180                185                190
Lys Asp Tyr Trp Glu Ser Gly Glu Trp Ala Ile Ile Lys Ala Pro Gly 
         195                200                205
Tyr Lys His Glu Ile Lys Tyr Asn Cys Cys Glu Glu Ile Tyr Gln Asp 
     210                215                220
Ile Thr Tyr Ser Leu Tyr Ile Arg Arg Leu Pro Leu Phe Tyr Thr Ile 
 225                230                235                240
Asn Leu Ile Ile Pro Cys Leu Leu Ile Ser Phe Leu Thr Val Leu Val 
                 245                250                255
Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys Val Thr Leu Cys Ile Ser 
             260                265                270
Val Leu Leu Ser Leu Thr Val Phe Leu Leu Val Ile Thr Glu Thr Ile 
         275                280                285
Pro Ser Thr Ser Leu Val Ile Pro Leu Ile Gly Glu Tyr Leu Leu Phe 
     290                295                300
Thr Met Ile Phe Val Thr Leu Ser Ile Val Ile Thr Val Phe Val Leu 
 305                310                315                320
Asn Val His Tyr Arg Thr Pro Thr Thr His Thr Met Pro Thr Trp Val 
                 325                330                335
Lys Ala Val Phe Leu Asn Leu Leu Pro Arg Val Met Phe Met Thr Arg 
             340                345                350
Pro Thr Ser Gly Glu Gly Asp Thr Pro Lys Thr Arg Thr Phe Tyr Gly 
         355                360                365
Ala Glu Leu Ser Asn Leu Asn Cys Phe Ser Arg Ala Asp Ser Lys Ser 
     370                375                380
Cys Lys Glu Gly Tyr Pro Cys Gln Asp Gly Thr Cys Gly Tyr Cys His 
 385                390                395                400
His Arg Arg Val Lys Ile Ser Asn Phe Ser Ala Asn Leu Thr Arg Ser 
                 405                410                415
Ser Ser Ser Glu Ser Val Asn Ala Val Leu Ser Leu Ser Ala Leu Ser 
             420                425                430
Pro Glu Ile Lys Glu Ala Ile Gln Ser Val Lys Tyr Ile Ala Glu Asn 
         435                440                445
Met Lys Ala Gln Asn Val Ala Lys Glu Ile Gln Asp Asp Trp Lys Tyr 
     450                455                460
Val Ala Met Val Ile Asp Arg Ile Phe Leu Trp Val Phe Ile Leu Val 
 465                470                475                480
Cys Ile Leu Gly Thr Ala Gly Leu Phe Leu Gln Pro Leu Met Ala Arg 
                 485                490                495
Asp Asp Thr 
             500



<210> 3174
<211> 1425
<212> DNA
<213> Homo sapiens
<308> X53559
<400> 3174

tcagaggct  agcaccgtc  atttgagcg  ctgtttgaa  attacaatg  gatcatccg  60
cctgtagcc  acgtgtctg  cccagtcat  atccatttc  aggtgtcca  gtctcagct  120
gtgaaggtg  atgaagtaa  ccagatcat  gagaccaac  tgtggctca  gcaaatctg  180
aatgactac  agctgaaat  gaacccctc  gactatggt  gggcagagt  catgcgtgt  240
cctgcacag  agatctgga  gccagacat  gtgctgtat  acaatgctg  tggggattt  300
caggtggac  acaagacca  agccttact  aagtacact  gggaggtga  ttggatacc  360
ccggccatc  ttaagagct  ctgtaaaat  gacgtgacc  acttcccgt  tgattacca  420
aactgtacc  tgaagttcg  ttcctggtc  tacgataag  cgaaaatcg  tctggtcct  480
atcggctct  ccatgaacc  caaggacta  tgggagagc  gcgagtggg  catcatcaa  540
gccccaggc  acaaacacg  catcaagta  aactgctgc  aggagatct  ccccgacat  600
acatactcg  tgtacatcc  gcgcctgcc  ttgttctac  ccatcaacc  catcatccc  660
tgcctgctc  tctccttcc  cactgtgct  gtcttctac  tgccctccg  ctgcggtga  720
aaggtgacc  tgtgcattt  tgtcctcct  tccctgacg  tgtttctcc  ggtgatcac  780
gagaccatc  cttccacct  gctggtcat  cccctgatt  gagagtacc  cctgttcac  840
atgattttt  taaccttgt  catcgtcat  accgtcttc  tgctcaacg  gcactacag  900
accccgacg  cacacacaa  gccctcatg  gtgaagact  tattcttga  cctgctccc  960
agggtcatg  tcatgacca  gccaacaag  aacgagggc  acgctcaga  gccgaggcc  1020
ctctacggt  ccgagctct  aaatctgaa  tgcttcagc  gcgcagagt  caaaggctg  1080
aaggagggc  acccctgcc  ggacgggat  tgtggttac  gccaccacc  caggataaa  1140
atctccaat  tcagtgcta  cctcacgag  agctctagt  ctgaatctg  tgatgctgt  1200
ctgtccctc  ctgctttgt  accagaaat  aaagaagcc  tccaaagtg  caagtatat  1260
gctgaaaat  tgaaagcac  aaatgaagc  aaagagatt  aagatgatt  gaagtatgt  1320
gccatggtg  ttgatcgta  ttttctgtg  gttttcacc  tggtgtgca  tctagggac  1380
gcaggattg  ttctgcaac  cctgatggc  agggaagat  cataa  1425



<210> 3175
<211> 503
<212> PRT
<213> Homo sapiens
<308> P32297
<400> 3175

Met Ala Leu Ala Val Ser Leu Pro Leu Ala Leu Ser Pro Pro Arg Leu 
  1               5                  10                  15
Leu Leu Leu Leu Leu Ser Leu Leu Pro Val Ala Arg Ala Ser Glu Ala 
             20                  25                  30
Glu His Arg Leu Phe Glu Arg Leu Phe Glu Asp Tyr Asn Glu Ile Ile 
         35                  40                  45
Arg Pro Val Ala Asn Val Ser Asp Pro Val Ile Ile His Phe Glu Val 
     50                  55                  60
Ser Met Ser Gln Leu Val Lys Val Asp Glu Val Asn Gln Ile Met Glu 
 65                  70                  75                  80
Thr Asn Leu Trp Leu Lys Gln Ile Trp Asn Asp Tyr Lys Leu Lys Trp 
                 85                  90                  95
Asn Pro Ser Asp Tyr Gly Gly Ala Glu Phe Met Arg Val Pro Ala Gln 
             100                105                110
Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val Gly Asp 
         115                120                125
Phe Gln Val Asp Asp Lys Thr Lys Ala Leu Leu Lys Tyr Thr Gly Glu 
     130                135                140
Val Thr Trp Ile Pro Pro Ala Ile Phe Lys Ser Ser Cys Lys Ile Asp 
 145                150                155                160
Val Thr Tyr Phe Pro Phe Asp Tyr Gln Asn Cys Thr Met Lys Phe Gly 
                 165                170                175
Ser Trp Ser Tyr Asp Lys Ala Lys Ile Asp Leu Val Leu Ile Gly Ser 
             180                185                190
Ser Met Asn Leu Lys Asp Tyr Trp Glu Ser Gly Glu Trp Ala Ile Ile 
         195                200                205
Lys Ala Pro Gly Tyr Lys His Asp Ile Lys Tyr Asn Cys Cys Glu Glu 
     210                215                220
Ile Tyr Pro Asp Ile Thr Tyr Ser Leu Tyr Ile Arg Arg Leu Pro Leu 
 225                230                235                240
Phe Tyr Thr Ile Asn Leu Ile Ile Pro Cys Leu Leu Ile Ser Phe Leu 
                 245                250                255
Thr Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys Val Thr 
             260                265                270
Leu Cys Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu Val Ile 
         275                280                285
Thr Glu Thr Ile Pro Ser Thr Ser Leu Val Ile Pro Leu Ile Gly Glu 
     290                295                300
Tyr Leu Leu Phe Thr Met Ile Phe Val Thr Leu Ser Ile Val Ile Thr 
 305                310                315                320
Val Phe Val Leu Asn Val His Tyr Arg Thr Pro Thr Thr His Thr Met 
                 325                330                335
Pro Ser Trp Val Lys Thr Val Phe Leu Asn Leu Leu Pro Arg Val Met 
             340                345                350
Phe Met Thr Arg Pro Thr Ser Asn Glu Gly Asn Ala Gln Lys Pro Arg 
         355                360                365
Pro Leu Tyr Gly Ala Glu Leu Ser Asn Leu Asn Cys Phe Ser Arg Ala 
     370                375                380
Glu Ser Lys Gly Cys Lys Glu Gly Tyr Pro Cys Gln Asp Gly Met Cys 
 385                390                395                400
Gly Tyr Cys His His Arg Arg Ile Lys Ile Ser Asn Phe Ser Ala Asn 
                 405                410                415
Leu Thr Arg Ser Ser Ser Ser Glu Ser Val Asp Ala Val Leu Ser Leu 
             420                425                430
Ser Ala Leu Ser Pro Glu Ile Lys Glu Ala Ile Gln Ser Val Lys Tyr 
         435                440                445
Ile Ala Glu Asn Met Lys Ala Gln Asn Glu Ala Lys Glu Ile Gln Asp 
     450                455                460
Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Ile Phe Leu Trp Val 
 465                470                475                480
Phe Thr Leu Val Cys Ile Leu Gly Thr Ala Gly Leu Phe Leu Gln Pro 
                 485                490                495
Leu Met Ala Arg Glu Asp Ala 
             500



<210> 3176
<211> 1858
<212> DNA
<213> Rattus norvegicus
<308> L31621
<400> 3176

ggtgccagc  cttgagtag  tgtgcttcg  tggtcagca  cagagtgtc  ccctccctg  60
ctatcgggt  ttagacatg  gtgttgtgc  gctcccgcc  ccgctgtcc  tgctgatgc  120
ggtgctgat  ctgctgcca  cggccagtg  ctcagaagc  gagcaccgc  tgttccagt  180
cctgttcga  gattacaac  agatcatcc  gccagtggc  aatgtgtcc  atccagtca  240
catccagtt  gaggtgtcc  tgtctcagc  ggtgaaggt  gatgaagta  accagatca  300
ggaaaccaa  ctgtggctg  agcaaatct  gaatgacta  aagctgaaa  ggaaaccct  360
tgactacca  ggggtggag  tcatgcgtg  tcctgcaga  aagatctgg  aaccagaca  420
cgtactgta  aacaacgct  atggggatt  ccaggtgga  gacaagacc  aagctctac  480
caagtacac  ggagaagtg  cttggatcc  gccggccat  tttaagagc  catgcaaaa  540
cgacgtgac  tacttccca  tcgactacc  aaactgcac  atgaagttc  gctcctggt  600
ctacgacaa  gcaaagatc  acctggtcc  catcggctc  tccatgaac  tcaaggact  660
ctgggagag  ggcgagtgg  ctatcatta  agccccggg  tacaaacat  aaatcaagt  720
caactgctg  gaggagatc  accaagaca  cacgtactc  ctgtacatc  gtcgcctgc  780
gctgttcta  accatcaac  tcatcatcc  ctgcctgct  atctccttc  tcactgtgc  840
tgtcttcta  ctgccctcc  actgtgggg  gaaggtgac  ctctgcatc  ctgtgctcc  900
ctccctgac  gtctttctc  tggtgatca  cgagaccat  ccttccacc  cgctggtca  960
ccccctgat  ggggagtac  tcctcttca  tatgatttt  gtcaccttg  ccattgtca  1020
cacagtctt  gtgctcaat  tgcactata  aactccaac  acacacacc  tgcccactt  1080
ggtcaaggc  gtgttcttg  acctgctcc  cagggtcat  tttatgact  ggccgacca  1140
tggtgaggg  gacactcct  agacgagga  cttctacgg  gctgagctc  caaacctga  1200
ctgcttcag  cgtgcagac  ccaaaagct  caaggaagg  tacccctgc  aagatggga  1260
ctgtggcta  tgccaccac  gtagggtaa  aatctcaaa  ttcagtgcc  acctcacaa  1320
aagctccag  tctgagtct  tcaacgctg  gttgtccct  tctgccctg  caccagaaa  1380
caaagaagc  atccaaagt  tgaagtaca  tgccgaaaa  atgaaagca  agaatgtag  1440
caaagagat  caagatgat  ggaagtacg  tgccatggt  attgatcgc  tctttctct  1500
ggttttcat  ctggtgtgc  ttttaggaa  ggcgggatt  tttctgcaa  ccttgatgg  1560
cagagatga  acatagact  tgcactgtt  atcgaggct  acctgtgct  acgcaaggg  1620
ccacttcct  aatagcact  tactttatc  gatcactgg  ttggagttt  ctatttcaa  1680
ggttatttt  aactcatct  gatttttcg  aaaaaagaa  tgtgggaga  aaatgtcta  1740
ttatttatc  tgggtaaat  aacatttca  tacccctgt  attgaaact  taggtagaa  1800
aattttctg  tcataaata  taactccat  agtgcagga  ctccataaa  tcatttct  1858



<210> 3177
<211> 499
<212> PRT
<213> Rattus norvegicus
<308> P04757
<400> 3177

Met Gly Val Val Leu Leu Pro Pro Pro Leu Ser Met Leu Met Leu Val 
  1               5                  10                  15
Leu Met Leu Leu Pro Ala Ala Ser Ala Ser Glu Ala Glu His Arg Leu 
             20                  25                  30
Phe Gln Tyr Leu Phe Glu Asp Tyr Asn Glu Ile Ile Arg Pro Val Ala 
         35                  40                  45
Asn Val Ser His Pro Val Ile Ile Gln Phe Glu Val Ser Met Ser Gln 
     50                  55                  60
Leu Val Lys Val Asp Glu Val Asn Gln Ile Met Glu Thr Asn Leu Trp 
 65                  70                  75                  80
Leu Lys Gln Ile Trp Asn Asp Tyr Lys Leu Lys Trp Lys Pro Ser Asp 
                 85                  90                  95
Tyr Gln Gly Val Glu Phe Met Arg Val Pro Ala Glu Lys Ile Trp Lys 
             100                105                110
Pro Asp Ile Val Leu Tyr Asn Asn Ala Asp Gly Asp Phe Gln Val Asp 
         115                120                125
Asp Lys Thr Lys Ala Leu Leu Lys Tyr Thr Gly Glu Val Thr Trp Ile 
     130                135                140
Pro Pro Ala Ile Phe Lys Ser Ser Cys Lys Ile Asp Val Thr Tyr Phe 
 145                150                155                160
Pro Phe Asp Tyr Gln Asn Cys Thr Met Lys Phe Gly Ser Trp Ser Tyr 
                 165                170                175
Asp Lys Ala Lys Ile Asp Leu Val Leu Ile Gly Ser Ser Met Asn Leu 
             180                185                190
Lys Asp Tyr Trp Glu Ser Gly Glu Trp Ala Ile Ile Lys Ala Pro Gly 
         195                200                205
Tyr Lys His Glu Ile Lys Tyr Asn Cys Cys Glu Glu Ile Tyr Gln Asp 
     210                215                220
Ile Thr Tyr Ser Leu Tyr Ile Arg Arg Leu Pro Leu Phe Tyr Thr Ile 
 225                230                235                240
Asn Leu Ile Ile Pro Cys Leu Leu Ile Ser Phe Leu Thr Val Leu Val 
                 245                250                255
Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys Val Thr Leu Cys Ile Ser 
             260                265                270
Val Leu Leu Ser Leu Thr Val Phe Leu Leu Val Ile Thr Glu Thr Ile 
         275                280                285
Pro Ser Thr Ser Leu Val Ile Pro Leu Ile Gly Glu Tyr Leu Leu Phe 
     290                295                300
Thr Met Ile Phe Val Thr Leu Ser Ile Val Ile Thr Val Phe Val Leu 
 305                310                315                320
Asn Val His Tyr Arg Thr Pro Thr Thr His Thr Met Pro Thr Trp Val 
                 325                330                335
Lys Ala Val Phe Leu Asn Leu Leu Pro Arg Val Met Phe Met Thr Arg 
             340                345                350
Pro Thr Ser Gly Glu Gly Asp Thr Pro Lys Thr Arg Thr Phe Tyr Gly 
         355                360                365
Ala Glu Leu Ser Asn Leu Asn Cys Phe Ser Arg Ala Asp Ser Lys Ser 
     370                375                380
Cys Lys Glu Gly Tyr Pro Cys Gln Asp Gly Thr Cys Gly Tyr Cys His 
 385                390                395                400
His Arg Arg Val Lys Ile Ser Asn Phe Ser Ala Asn Leu Thr Arg Ser 
                 405                410                415
Ser Ser Ser Glu Ser Val Asn Ala Val Leu Ser Leu Ser Ala Leu Ser 
             420                425                430
Pro Glu Ile Lys Glu Ala Ile Gln Ser Val Lys Tyr Ile Ala Glu Asn 
         435                440                445
Met Lys Ala Gln Asn Val Ala Lys Glu Ile Gln Asp Asp Trp Lys Tyr 
     450                455                460
Val Ala Met Val Ile Asp Arg Ile Phe Leu Trp Val Phe Ile Leu Val 
 465                470                475                480
Cys Ile Leu Gly Thr Ala Gly Leu Phe Leu Gln Pro Leu Met Ala Arg 
                 485                490                495
Asp Asp Thr 
             500



<210> 3178
<211> 1425
<212> DNA
<213> Homo sapiens
<308> X53559
<400> 3178

tcagaggct  agcaccgtc  atttgagcg  ctgtttgaa  attacaatg  gatcatccg  60
cctgtagcc  acgtgtctg  cccagtcat  atccatttc  aggtgtcca  gtctcagct  120
gtgaaggtg  atgaagtaa  ccagatcat  gagaccaac  tgtggctca  gcaaatctg  180
aatgactac  agctgaaat  gaacccctc  gactatggt  gggcagagt  catgcgtgt  240
cctgcacag  agatctgga  gccagacat  gtgctgtat  acaatgctg  tggggattt  300
caggtggac  acaagacca  agccttact  aagtacact  gggaggtga  ttggatacc  360
ccggccatc  ttaagagct  ctgtaaaat  gacgtgacc  acttcccgt  tgattacca  420
aactgtacc  tgaagttcg  ttcctggtc  tacgataag  cgaaaatcg  tctggtcct  480
atcggctct  ccatgaacc  caaggacta  tgggagagc  gcgagtggg  catcatcaa  540
gccccaggc  acaaacacg  catcaagta  aactgctgc  aggagatct  ccccgacat  600
acatactcg  tgtacatcc  gcgcctgcc  ttgttctac  ccatcaacc  catcatccc  660
tgcctgctc  tctccttcc  cactgtgct  gtcttctac  tgccctccg  ctgcggtga  720
aaggtgacc  tgtgcattt  tgtcctcct  tccctgacg  tgtttctcc  ggtgatcac  780
gagaccatc  cttccacct  gctggtcat  cccctgatt  gagagtacc  cctgttcac  840
atgattttt  taaccttgt  catcgtcat  accgtcttc  tgctcaacg  gcactacag  900
accccgacg  cacacacaa  gccctcatg  gtgaagact  tattcttga  cctgctccc  960
agggtcatg  tcatgacca  gccaacaag  aacgagggc  acgctcaga  gccgaggcc  1020
ctctacggt  ccgagctct  aaatctgaa  tgcttcagc  gcgcagagt  caaaggctg  1080
aaggagggc  acccctgcc  ggacgggat  tgtggttac  gccaccacc  caggataaa  1140
atctccaat  tcagtgcta  cctcacgag  agctctagt  ctgaatctg  tgatgctgt  1200
ctgtccctc  ctgctttgt  accagaaat  aaagaagcc  tccaaagtg  caagtatat  1260
gctgaaaat  tgaaagcac  aaatgaagc  aaagagatt  aagatgatt  gaagtatgt  1320
gccatggtg  ttgatcgta  ttttctgtg  gttttcacc  tggtgtgca  tctagggac  1380
gcaggattg  ttctgcaac  cctgatggc  agggaagat  cataa  1425



<210> 3179
<211> 503
<212> PRT
<213> Homo sapiens
<308> P32297
<400> 3179

Met Ala Leu Ala Val Ser Leu Pro Leu Ala Leu Ser Pro Pro Arg Leu 
  1               5                  10                  15
Leu Leu Leu Leu Leu Ser Leu Leu Pro Val Ala Arg Ala Ser Glu Ala 
             20                  25                  30
Glu His Arg Leu Phe Glu Arg Leu Phe Glu Asp Tyr Asn Glu Ile Ile 
         35                  40                  45
Arg Pro Val Ala Asn Val Ser Asp Pro Val Ile Ile His Phe Glu Val 
     50                  55                  60
Ser Met Ser Gln Leu Val Lys Val Asp Glu Val Asn Gln Ile Met Glu 
 65                  70                  75                  80
Thr Asn Leu Trp Leu Lys Gln Ile Trp Asn Asp Tyr Lys Leu Lys Trp 
                 85                  90                  95
Asn Pro Ser Asp Tyr Gly Gly Ala Glu Phe Met Arg Val Pro Ala Gln 
             100                105                110
Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val Gly Asp 
         115                120                125
Phe Gln Val Asp Asp Lys Thr Lys Ala Leu Leu Lys Tyr Thr Gly Glu 
     130                135                140
Val Thr Trp Ile Pro Pro Ala Ile Phe Lys Ser Ser Cys Lys Ile Asp 
 145                150                155                160
Val Thr Tyr Phe Pro Phe Asp Tyr Gln Asn Cys Thr Met Lys Phe Gly 
                 165                170                175
Ser Trp Ser Tyr Asp Lys Ala Lys Ile Asp Leu Val Leu Ile Gly Ser 
             180                185                190
Ser Met Asn Leu Lys Asp Tyr Trp Glu Ser Gly Glu Trp Ala Ile Ile 
         195                200                205
Lys Ala Pro Gly Tyr Lys His Asp Ile Lys Tyr Asn Cys Cys Glu Glu 
     210                215                220
Ile Tyr Pro Asp Ile Thr Tyr Ser Leu Tyr Ile Arg Arg Leu Pro Leu 
 225                230                235                240
Phe Tyr Thr Ile Asn Leu Ile Ile Pro Cys Leu Leu Ile Ser Phe Leu 
                 245                250                255
Thr Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys Val Thr 
             260                265                270
Leu Cys Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu Val Ile 
         275                280                285
Thr Glu Thr Ile Pro Ser Thr Ser Leu Val Ile Pro Leu Ile Gly Glu 
     290                295                300
Tyr Leu Leu Phe Thr Met Ile Phe Val Thr Leu Ser Ile Val Ile Thr 
 305                310                315                320
Val Phe Val Leu Asn Val His Tyr Arg Thr Pro Thr Thr His Thr Met 
                 325                330                335
Pro Ser Trp Val Lys Thr Val Phe Leu Asn Leu Leu Pro Arg Val Met 
             340                345                350
Phe Met Thr Arg Pro Thr Ser Asn Glu Gly Asn Ala Gln Lys Pro Arg 
         355                360                365
Pro Leu Tyr Gly Ala Glu Leu Ser Asn Leu Asn Cys Phe Ser Arg Ala 
     370                375                380
Glu Ser Lys Gly Cys Lys Glu Gly Tyr Pro Cys Gln Asp Gly Met Cys 
 385                390                395                400
Gly Tyr Cys His His Arg Arg Ile Lys Ile Ser Asn Phe Ser Ala Asn 
                 405                410                415
Leu Thr Arg Ser Ser Ser Ser Glu Ser Val Asp Ala Val Leu Ser Leu 
             420                425                430
Ser Ala Leu Ser Pro Glu Ile Lys Glu Ala Ile Gln Ser Val Lys Tyr 
         435                440                445
Ile Ala Glu Asn Met Lys Ala Gln Asn Glu Ala Lys Glu Ile Gln Asp 
     450                455                460
Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Ile Phe Leu Trp Val 
 465                470                475                480
Phe Thr Leu Val Cys Ile Leu Gly Thr Ala Gly Leu Phe Leu Gln Pro 
                 485                490                495
Leu Met Ala Arg Glu Asp Ala 
             500



<210> 3180
<211> 711
<212> DNA
<213> Rattus norvegicus
<308> L32591
<400> 3180

gggactcgc  cttgcaata  gactttgga  gaattctcg  ccgcagagc  gaagatcga  60
aggatggac  cggtgggcg  tgccctgga  gaagtgctc  gcaaggctc  gagtcagcg  120
accataact  tcggcgtgt  cgaggcagc  aagctgctc  acgtagacc  ggacaacgt  180
gtcctgtgc  tgctggctg  ggatgaaga  gacgaccgg  acgtggctc  gcagatcca  240
ttcaccctc  ttcgtgctt  ctgttgcga  aacgacatc  acatcctgc  ggtcagcaa  300
ccgggtcgg  tggcagagc  gttgctact  gagaacgac  agagccccg  tgagagcgg  360
ggcctggcg  agaccccgg  cttacactg  gtgctggtg  cgaacccac  ttcatcaca  420
tggaaggat  ctgccttaa  tcaacttat  tgtttttgc  gggaaagtc  ctacatgga  480
cagtgggtg  cagtgatta  tctccccga  cggtgattc  ccgaacggt  atggcatct  540
aatggaaat  actgaacca  attgcactg  agttttgaa  tacctttgt  gttactcaa  600
cagtcactc  ccacgctga  gcaaggatt  cagaaactg  tgtcaaggg  ctgagttca  660
ctacaggag  gctaggaga  gactttgca  atggacaga  aggtgaaaa  a  711



<210> 3181
<211> 165
<212> PRT
<213> Rattus norvegicus
<308> P48317
<400> 3181

Met Thr Leu Glu Glu Phe Ser Ala Ala Glu Gln Lys Ile Glu Arg Met 
  1               5                  10                  15
Asp Thr Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Arg Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Arg Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Asn Asp Lys Ser Pro Ala Glu 
             100                105                110
Ser Gly Gly Leu Ala Gln Thr Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 3182
<211> 1343
<212> DNA
<213> Homo sapiens
<308> M60974
<400> 3182

ggcagtggc  gggaggcag  ggcccaatt  gtgtcgtgc  gcccgtggc  aggcgaggt  60
cggggagcg  gcgagcaag  aaggcggga  gggtggccg  agctgcggc  gctggcaca  120
gaggaggag  ccgggcggg  gaggggcgg  cggagagcg  cagggcctg  gctgccgga  180
cggcgcctg  gagtgagtg  agaaagcag  cgcccgcgc  ctagccgtg  caggagcag  240
ccgcacgcc  cgctctctc  ctgggcgac  tgcagtttg  aatatgact  tggaggaat  300
ctcggctgg  gagcagaag  ccgaaagga  ggataaggt  ggggatgcc  tggaggaag  360
gctcagcaa  gccctgagt  agcgcacga  cactgtcgg  gtgtacgaa  cggccaagc  420
gctcaacgt  gaccccgat  acgtggtgt  gtgcctgct  gcggcggac  aggacgacg  480
cagagatgt  gctctgcag  tccacttca  cctgatcca  gcgttttgc  gcgagaacg  540
catcaacat  ctgcgcgtc  gcaacccgg  ccggctggc  gagctcctg  tcttggaga  600
cgacgctgg  cccgcggcg  gcgagggcg  cgagcagcc  ccggacctg  actgcgtgc  660
ggtgacgaa  ccacattca  ctcaatgga  ggatcctgc  ttaagtcaa  ttatttgtt  720
ttgccggga  agtcgctac  tggatcaat  ggttccagt  attaatctc  ctgaacggt  780
atggcatct  aatgaaaat  actgaacca  attgcactg  agtttttga  atacctttg  840
agttactca  gcagttact  cctacactg  tgcaaggat  acagaaact  atgccaagg  900
gctgagtga  ttcaactac  tgttctggg  gcccggaga  agatgactt  gcagatgga  960
agaggtgaa  atgaagaag  aagctgtgt  gaaacagaa  aataagtca  aaggaacaa  1020
aattacaaa  aaccatgca  gaaggaaaa  tatgtatta  tttagaatg  ttgagttac  1080
ttaaaataa  ccaaatatg  taaagttta  gtgtgcagc  atagtttgg  tatttttgg  1140
ttatatgcc  tcaagtaaa  gaaaagccg  aagggttaa  catatttga  aaccatatt  1200
tattgtatt  tgatgagat  ttaaattct  aaagtttta  tataaattc  actaagtta  1260
tttatgaca  gaaaagtta  ttatgctat  aattttttg  aacacaata  ctacaataa  1320
ctggtatga  taattgcat  att  1343



<210> 3183
<211> 165
<212> PRT
<213> Homo sapiens
<308> P24522
<400> 3183

Met Thr Leu Glu Glu Phe Ser Ala Gly Glu Gln Lys Thr Glu Arg Met 
  1               5                  10                  15
Asp Lys Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Leu Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Gln Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Thr Asp Ala Gly Pro Ala Ala 
             100                105                110
Ser Glu Gly Ala Glu Gln Pro Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 3184
<211> 711
<212> DNA
<213> Rattus norvegicus
<308> L32591
<400> 3184

gggactcgc  cttgcaata  gactttgga  gaattctcg  ccgcagagc  gaagatcga  60
aggatggac  cggtgggcg  tgccctgga  gaagtgctc  gcaaggctc  gagtcagcg  120
accataact  tcggcgtgt  cgaggcagc  aagctgctc  acgtagacc  ggacaacgt  180
gtcctgtgc  tgctggctg  ggatgaaga  gacgaccgg  acgtggctc  gcagatcca  240
ttcaccctc  ttcgtgctt  ctgttgcga  aacgacatc  acatcctgc  ggtcagcaa  300
ccgggtcgg  tggcagagc  gttgctact  gagaacgac  agagccccg  tgagagcgg  360
ggcctggcg  agaccccgg  cttacactg  gtgctggtg  cgaacccac  ttcatcaca  420
tggaaggat  ctgccttaa  tcaacttat  tgtttttgc  gggaaagtc  ctacatgga  480
cagtgggtg  cagtgatta  tctccccga  cggtgattc  ccgaacggt  atggcatct  540
aatggaaat  actgaacca  attgcactg  agttttgaa  tacctttgt  gttactcaa  600
cagtcactc  ccacgctga  gcaaggatt  cagaaactg  tgtcaaggg  ctgagttca  660
ctacaggag  gctaggaga  gactttgca  atggacaga  aggtgaaaa  a  711



<210> 3185
<211> 165
<212> PRT
<213> Rattus norvegicus
<308> P48317
<400> 3185

Met Thr Leu Glu Glu Phe Ser Ala Ala Glu Gln Lys Ile Glu Arg Met 
  1               5                  10                  15
Asp Thr Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Arg Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Arg Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Asn Asp Lys Ser Pro Ala Glu 
             100                105                110
Ser Gly Gly Leu Ala Gln Thr Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 3186
<211> 1343
<212> DNA
<213> Homo sapiens
<308> M60974
<400> 3186

ggcagtggc  gggaggcag  ggcccaatt  gtgtcgtgc  gcccgtggc  aggcgaggt  60
cggggagcg  gcgagcaag  aaggcggga  gggtggccg  agctgcggc  gctggcaca  120
gaggaggag  ccgggcggg  gaggggcgg  cggagagcg  cagggcctg  gctgccgga  180
cggcgcctg  gagtgagtg  agaaagcag  cgcccgcgc  ctagccgtg  caggagcag  240
ccgcacgcc  cgctctctc  ctgggcgac  tgcagtttg  aatatgact  tggaggaat  300
ctcggctgg  gagcagaag  ccgaaagga  ggataaggt  ggggatgcc  tggaggaag  360
gctcagcaa  gccctgagt  agcgcacga  cactgtcgg  gtgtacgaa  cggccaagc  420
gctcaacgt  gaccccgat  acgtggtgt  gtgcctgct  gcggcggac  aggacgacg  480
cagagatgt  gctctgcag  tccacttca  cctgatcca  gcgttttgc  gcgagaacg  540
catcaacat  ctgcgcgtc  gcaacccgg  ccggctggc  gagctcctg  tcttggaga  600
cgacgctgg  cccgcggcg  gcgagggcg  cgagcagcc  ccggacctg  actgcgtgc  660
ggtgacgaa  ccacattca  ctcaatgga  ggatcctgc  ttaagtcaa  ttatttgtt  720
ttgccggga  agtcgctac  tggatcaat  ggttccagt  attaatctc  ctgaacggt  780
atggcatct  aatgaaaat  actgaacca  attgcactg  agtttttga  atacctttg  840
agttactca  gcagttact  cctacactg  tgcaaggat  acagaaact  atgccaagg  900
gctgagtga  ttcaactac  tgttctggg  gcccggaga  agatgactt  gcagatgga  960
agaggtgaa  atgaagaag  aagctgtgt  gaaacagaa  aataagtca  aaggaacaa  1020
aattacaaa  aaccatgca  gaaggaaaa  tatgtatta  tttagaatg  ttgagttac  1080
ttaaaataa  ccaaatatg  taaagttta  gtgtgcagc  atagtttgg  tatttttgg  1140
ttatatgcc  tcaagtaaa  gaaaagccg  aagggttaa  catatttga  aaccatatt  1200
tattgtatt  tgatgagat  ttaaattct  aaagtttta  tataaattc  actaagtta  1260
tttatgaca  gaaaagtta  ttatgctat  aattttttg  aacacaata  ctacaataa  1320
ctggtatga  taattgcat  att  1343



<210> 3187
<211> 165
<212> PRT
<213> Homo sapiens
<308> P24522
<400> 3187

Met Thr Leu Glu Glu Phe Ser Ala Gly Glu Gln Lys Thr Glu Arg Met 
  1               5                  10                  15
Asp Lys Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Leu Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Gln Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Thr Asp Ala Gly Pro Ala Ala 
             100                105                110
Ser Glu Gly Ala Glu Gln Pro Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 3188
<211> 711
<212> DNA
<213> Rattus norvegicus
<308> L32591
<400> 3188

gggactcgc  cttgcaata  gactttgga  gaattctcg  ccgcagagc  gaagatcga  60
aggatggac  cggtgggcg  tgccctgga  gaagtgctc  gcaaggctc  gagtcagcg  120
accataact  tcggcgtgt  cgaggcagc  aagctgctc  acgtagacc  ggacaacgt  180
gtcctgtgc  tgctggctg  ggatgaaga  gacgaccgg  acgtggctc  gcagatcca  240
ttcaccctc  ttcgtgctt  ctgttgcga  aacgacatc  acatcctgc  ggtcagcaa  300
ccgggtcgg  tggcagagc  gttgctact  gagaacgac  agagccccg  tgagagcgg  360
ggcctggcg  agaccccgg  cttacactg  gtgctggtg  cgaacccac  ttcatcaca  420
tggaaggat  ctgccttaa  tcaacttat  tgtttttgc  gggaaagtc  ctacatgga  480
cagtgggtg  cagtgatta  tctccccga  cggtgattc  ccgaacggt  atggcatct  540
aatggaaat  actgaacca  attgcactg  agttttgaa  tacctttgt  gttactcaa  600
cagtcactc  ccacgctga  gcaaggatt  cagaaactg  tgtcaaggg  ctgagttca  660
ctacaggag  gctaggaga  gactttgca  atggacaga  aggtgaaaa  a  711



<210> 3189
<211> 165
<212> PRT
<213> Rattus norvegicus
<308> P48317
<400> 3189

Met Thr Leu Glu Glu Phe Ser Ala Ala Glu Gln Lys Ile Glu Arg Met 
  1               5                  10                  15
Asp Thr Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Arg Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Arg Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Asn Asp Lys Ser Pro Ala Glu 
             100                105                110
Ser Gly Gly Leu Ala Gln Thr Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 3190
<211> 1343
<212> DNA
<213> Homo sapiens
<308> M60974
<400> 3190

ggcagtggc  gggaggcag  ggcccaatt  gtgtcgtgc  gcccgtggc  aggcgaggt  60
cggggagcg  gcgagcaag  aaggcggga  gggtggccg  agctgcggc  gctggcaca  120
gaggaggag  ccgggcggg  gaggggcgg  cggagagcg  cagggcctg  gctgccgga  180
cggcgcctg  gagtgagtg  agaaagcag  cgcccgcgc  ctagccgtg  caggagcag  240
ccgcacgcc  cgctctctc  ctgggcgac  tgcagtttg  aatatgact  tggaggaat  300
ctcggctgg  gagcagaag  ccgaaagga  ggataaggt  ggggatgcc  tggaggaag  360
gctcagcaa  gccctgagt  agcgcacga  cactgtcgg  gtgtacgaa  cggccaagc  420
gctcaacgt  gaccccgat  acgtggtgt  gtgcctgct  gcggcggac  aggacgacg  480
cagagatgt  gctctgcag  tccacttca  cctgatcca  gcgttttgc  gcgagaacg  540
catcaacat  ctgcgcgtc  gcaacccgg  ccggctggc  gagctcctg  tcttggaga  600
cgacgctgg  cccgcggcg  gcgagggcg  cgagcagcc  ccggacctg  actgcgtgc  660
ggtgacgaa  ccacattca  ctcaatgga  ggatcctgc  ttaagtcaa  ttatttgtt  720
ttgccggga  agtcgctac  tggatcaat  ggttccagt  attaatctc  ctgaacggt  780
atggcatct  aatgaaaat  actgaacca  attgcactg  agtttttga  atacctttg  840
agttactca  gcagttact  cctacactg  tgcaaggat  acagaaact  atgccaagg  900
gctgagtga  ttcaactac  tgttctggg  gcccggaga  agatgactt  gcagatgga  960
agaggtgaa  atgaagaag  aagctgtgt  gaaacagaa  aataagtca  aaggaacaa  1020
aattacaaa  aaccatgca  gaaggaaaa  tatgtatta  tttagaatg  ttgagttac  1080
ttaaaataa  ccaaatatg  taaagttta  gtgtgcagc  atagtttgg  tatttttgg  1140
ttatatgcc  tcaagtaaa  gaaaagccg  aagggttaa  catatttga  aaccatatt  1200
tattgtatt  tgatgagat  ttaaattct  aaagtttta  tataaattc  actaagtta  1260
tttatgaca  gaaaagtta  ttatgctat  aattttttg  aacacaata  ctacaataa  1320
ctggtatga  taattgcat  att  1343



<210> 3191
<211> 165
<212> PRT
<213> Homo sapiens
<308> P24522
<400> 3191

Met Thr Leu Glu Glu Phe Ser Ala Gly Glu Gln Lys Thr Glu Arg Met 
  1               5                  10                  15
Asp Lys Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Leu Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Gln Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Thr Asp Ala Gly Pro Ala Ala 
             100                105                110
Ser Glu Gly Ala Glu Gln Pro Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 3192
<211> 711
<212> DNA
<213> Rattus norvegicus
<308> L32591
<400> 3192

gggactcgc  cttgcaata  gactttgga  gaattctcg  ccgcagagc  gaagatcga  60
aggatggac  cggtgggcg  tgccctgga  gaagtgctc  gcaaggctc  gagtcagcg  120
accataact  tcggcgtgt  cgaggcagc  aagctgctc  acgtagacc  ggacaacgt  180
gtcctgtgc  tgctggctg  ggatgaaga  gacgaccgg  acgtggctc  gcagatcca  240
ttcaccctc  ttcgtgctt  ctgttgcga  aacgacatc  acatcctgc  ggtcagcaa  300
ccgggtcgg  tggcagagc  gttgctact  gagaacgac  agagccccg  tgagagcgg  360
ggcctggcg  agaccccgg  cttacactg  gtgctggtg  cgaacccac  ttcatcaca  420
tggaaggat  ctgccttaa  tcaacttat  tgtttttgc  gggaaagtc  ctacatgga  480
cagtgggtg  cagtgatta  tctccccga  cggtgattc  ccgaacggt  atggcatct  540
aatggaaat  actgaacca  attgcactg  agttttgaa  tacctttgt  gttactcaa  600
cagtcactc  ccacgctga  gcaaggatt  cagaaactg  tgtcaaggg  ctgagttca  660
ctacaggag  gctaggaga  gactttgca  atggacaga  aggtgaaaa  a  711



<210> 3193
<211> 165
<212> PRT
<213> Rattus norvegicus
<308> P48317
<400> 3193

Met Thr Leu Glu Glu Phe Ser Ala Ala Glu Gln Lys Ile Glu Arg Met 
  1               5                  10                  15
Asp Thr Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Arg Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Arg Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Asn Asp Lys Ser Pro Ala Glu 
             100                105                110
Ser Gly Gly Leu Ala Gln Thr Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 3194
<211> 1343
<212> DNA
<213> Homo sapiens
<308> M60974
<400> 3194

ggcagtggc  gggaggcag  ggcccaatt  gtgtcgtgc  gcccgtggc  aggcgaggt  60
cggggagcg  gcgagcaag  aaggcggga  gggtggccg  agctgcggc  gctggcaca  120
gaggaggag  ccgggcggg  gaggggcgg  cggagagcg  cagggcctg  gctgccgga  180
cggcgcctg  gagtgagtg  agaaagcag  cgcccgcgc  ctagccgtg  caggagcag  240
ccgcacgcc  cgctctctc  ctgggcgac  tgcagtttg  aatatgact  tggaggaat  300
ctcggctgg  gagcagaag  ccgaaagga  ggataaggt  ggggatgcc  tggaggaag  360
gctcagcaa  gccctgagt  agcgcacga  cactgtcgg  gtgtacgaa  cggccaagc  420
gctcaacgt  gaccccgat  acgtggtgt  gtgcctgct  gcggcggac  aggacgacg  480
cagagatgt  gctctgcag  tccacttca  cctgatcca  gcgttttgc  gcgagaacg  540
catcaacat  ctgcgcgtc  gcaacccgg  ccggctggc  gagctcctg  tcttggaga  600
cgacgctgg  cccgcggcg  gcgagggcg  cgagcagcc  ccggacctg  actgcgtgc  660
ggtgacgaa  ccacattca  ctcaatgga  ggatcctgc  ttaagtcaa  ttatttgtt  720
ttgccggga  agtcgctac  tggatcaat  ggttccagt  attaatctc  ctgaacggt  780
atggcatct  aatgaaaat  actgaacca  attgcactg  agtttttga  atacctttg  840
agttactca  gcagttact  cctacactg  tgcaaggat  acagaaact  atgccaagg  900
gctgagtga  ttcaactac  tgttctggg  gcccggaga  agatgactt  gcagatgga  960
agaggtgaa  atgaagaag  aagctgtgt  gaaacagaa  aataagtca  aaggaacaa  1020
aattacaaa  aaccatgca  gaaggaaaa  tatgtatta  tttagaatg  ttgagttac  1080
ttaaaataa  ccaaatatg  taaagttta  gtgtgcagc  atagtttgg  tatttttgg  1140
ttatatgcc  tcaagtaaa  gaaaagccg  aagggttaa  catatttga  aaccatatt  1200
tattgtatt  tgatgagat  ttaaattct  aaagtttta  tataaattc  actaagtta  1260
tttatgaca  gaaaagtta  ttatgctat  aattttttg  aacacaata  ctacaataa  1320
ctggtatga  taattgcat  att  1343



<210> 3195
<211> 165
<212> PRT
<213> Homo sapiens
<308> P24522
<400> 3195

Met Thr Leu Glu Glu Phe Ser Ala Gly Glu Gln Lys Thr Glu Arg Met 
  1               5                  10                  15
Asp Lys Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Leu Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Gln Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Thr Asp Ala Gly Pro Ala Ala 
             100                105                110
Ser Glu Gly Ala Glu Gln Pro Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 3196
<211> 3700
<212> DNA
<213> Rattus norvegicus
<308> L33869
<400> 3196

ccaagagga  gaaacatga  gtttttgct  cttagtgca  ttttatttt  gcatagttc  60
ttagcttgg  caagagaaa  gcattatta  atcggaatt  ctgaagcag  ttgggacta  120
gcttctggc  gtgaagaaa  ggaacttat  tcagttgac  cggaacagt  caatttcta  180
cttcgaaat  gtccagatc  tattggaag  aagtataag  aggcccttt  ttctgagta  240
acagatggc  cctttacga  gactataga  aaaccagcc  ggctagggt  tttaggccc  300
gtcatcaaa  ctgaagttg  agacaaagt  tctgttcac  taaagaact  tgcctctag  360
ccctacact  ttcatgctc  tggggtaac  tacaccaag  cgaacgagg  ggccatcta  420
cctgacaac  ccactgatt  tcaaagagc  gatgacaaa  tgtttcctg  acagcagta  480
ttgtacgtg  tgcgtgcca  tgagccaag  cctggcgag  gagacagca  ttgtgtgac  540
aggatttac  actctcatg  ggatgctcc  aaagatatt  catcaggac  cataggacc  600
ttgatactc  gtaaaaaag  ttctctgca  aaggaaaaa  aggaaaata  tgaccaaga  660
ttcgtactg  tgttctctg  ggtggatga  aatctcagc  ggtacctag  agataacat  720
aaaaccttc  gctctgaac  agagaaagt  gataaagac  atgaagact  ccaggaaag  780
aacaggatg  actctataa  tggatatac  tttggaagc  tcccagggc  ctcgatgtg  840
gcagaagac  gagtgaagt  gtacctttt  gggatgggg  atgaagttg  cgtgcattc  900
gagctcttt  atggtcaag  cctgaccag  aagaactat  atactgata  aatcaacct  960
ttccctgcc  ctctaattg  tgtttctat  gtggcccag  atcctggag  ctggatgct  1020
agttgccag  acctgaacc  tctgaaagc  ggtttgcag  cctttttcc  ggttcgtga  1080
tgcaacaag  cctcaccgg  cgacgatat  caagacaga  atgtgagac  ttattacat  1140
gctgccgag  agaccattt  ggactatgc  ccgtctggg  cagacacct  cactggaga  1200
aacttcacc  gtctgggaa  tgattcaag  gtctttttt  agcaaggtg  tacaagaat  1260
ggtggctct  ataaaaaat  ggtttatcg  gagtacaca  atgattcct  cacaaaccg  1320
aaggaaaga  gccctgatg  ggaacatct  ggaatcctt  gtcctgtca  ttgggcaga  1380
gtaggagac  tcattagag  cacctttca  aacaaagga  aatttcctc  cagcattca  1440
ccaatgggg  taagattca  caaggaaaa  gagggaaca  actatggcc  agatggccg  1500
tcctcaaag  aagcctccc  tgtggctcc  aaagaaacc  ttacgtatg  atggactgt  1560
cccaaagaa  tgggaccca  ttatgcaga  cctgtgtgc  tatctaaga  gtattattc  1620
ggagttgac  tcaccaaag  tatatttac  gggcttatt  ggccaatga  aatatgcaa  1680
aaaggcagc  tacttgcag  tgggagaca  aaagatgta  acaaggagt  ctacttgtt  1740
gcaacagtg  ttgatgaga  tgagagttt  ctcttggat  ataatatca  aatgttcac  1800
actgcacct  agaatgtgg  caaggaaga  gaagacttt  aggagtcca  caagatgca  1860
tccatgaat  gattcatgt  tggcaatct  cctggcctc  atatgtgcc  aggagaatc  1920
atcgtgtgg  atttgttca  cgctggaaa  gaggcagac  tgcatggga  atacttttc  1980
ggaaatacc  atctgtcca  aggagaaag  agagacact  caaatctgt  tcctcataa  2040
agtctcacc  ttctcatga  acctgacac  gaagggtct  ttgatgttg  gtgtcttac  2100
acagatcac  acaccggcg  catgaagca  aagtacact  tgaaccagt  caaggggca  2160
tttgaagat  tcactctct  ccagggaga  aggacctac  atattgcag  agtggaggt  2220
gaatgggat  attcaccaa  cagggactg  gaaatggag  tgcaccatt  gcaagagca  2280
aatgtttca  atgcatttt  ggataagga  gagtttttc  taggctcaa  gtacaagaa  2340
gttgtgtat  gagagttta  tgacagcac  ttcagagaa  aggtgaaga  aagagctga  2400
gaggagcac  tgggcatgc  cggtccact  attcatgca  atgttggag  caaagttaa  2460
gttgtcttt  aaaatatgg  aacaaggcc  tattcaata  atgcccacg  agtgaaaac  2520
aagagttct  cagttgctc  aacgttgcc  ggtgaagtt  gcacttata  atggcaaat  2580
ccagaaaga  caggtgctg  aacggagga  tcaccttgt  tcccatggg  ttattactc  2640
accgtggat  gagttaagg  tctctacag  gggctaata  gcccattga  tgtttgtcg  2700
aaatcttat  tgaaagtat  caatcctaa  aagaaaatg  agttttccc  tttgtttct  2760
gtttttgat  agaatgaat  ttggtactt  gatgataac  tcaatacat  ccccgatca  2820
cctgagaaa  ataacaaag  caacgagga  ttcatagaa  gcaataaaa  gcatgctat  2880
aatgggaaa  tgttcggaa  cctccaagg  ctcacgatg  acgtgggag  tgaggtcaa  2940
tggtatgtg  tggctatgg  caatgaaat  gacctgcac  ctgtacact  ccacggcca  3000
agcttccaa  acaagcaca  gggaattca  agttctgat  tctttgact  tttccctgg  3060
acataccaa  ccctagaaa  gtttcccca  acgcctgga  cctggttac  ccactgcca  3120
gtgactgac  atattcatg  ggggatggt  actacctac  ctgttttac  aaatcaaga  3180
actaagtct  gctgaaaga  ataaattgg  gataagtgg  atacgagca  aatgacgtt  3240
ttttaaaca  ttaaaaaaa  caaagccac  caaatgttc  tttgtgagg  aattggtaa  3300
gccgatgga  agatgaaca  actgtatca  gacatgtat  tgtttgctg  gtaacagaa  3360
cgctttaca  agtccactt  cacctgcac  gaaaggact  tgaaaagtg  aaaaaaata  3420
gcaaaaccg  atgatcaga  gctgtcctt  actgtcctc  caggatcac  ataaagtcc  3480
ctaaactgt  tccaactct  ctcatcaag  cctctaaca  accatgggg  aagagggta  3540
agaaaagaa  gaaagatga  gataccaag  tgcactttg  aaaaatctg  aaaacagtt  3600
aaggatgct  tcggaaaat  gagaaagtc  ggatccaat  atgttacat  ttgaaaaaa  3660
gaaatggag  taataaagt  ataaatttt  aaatgccaat  3700



<210> 3197
<211> 1059
<212> PRT
<213> Rattus norvegicus
<308> P13635
<400> 3197

Met Lys Phe Leu Leu Leu Ser Ala Leu Leu Phe Leu His Ser Ser Leu 
  1               5                  10                  15
Ala Trp Thr Arg Glu Lys His Tyr Tyr Ile Gly Ile Thr Glu Ala Val 
             20                  25                  30
Trp Asp Tyr Ala Ser Gly Ser Glu Glu Lys Glu Leu Ile Ser Val Asp 
         35                  40                  45
Thr Glu Gln Ser Asn Phe Tyr Leu Arg Asn Gly Pro Asp Arg Ile Gly 
     50                  55                  60
Arg Lys Tyr Lys Lys Ala Leu Tyr Ser Glu Tyr Thr Asp Gly Thr Phe 
 65                  70                  75                  80
Thr Lys Thr Ile Asp Lys Pro Ala Trp Leu Gly Phe Leu Gly Pro Val 
                 85                  90                  95
Ile Lys Ala Glu Val Gly Asp Lys Val Ser Val His Val Lys Asn Phe 
             100                105                110
Ala Ser Arg Pro Tyr Thr Phe His Ala His Gly Val Thr Tyr Thr Lys 
         115                120                125
Ala Asn Glu Gly Ala Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln Arg 
     130                135                140
Ala Asp Asp Lys Leu Phe Pro Gly Gln Gln Tyr Leu Tyr Val Leu Arg 
 145                150                155                160
Ala Asn Glu Pro Ser Pro Gly Glu Gly Asp Ser Asn Cys Val Thr Arg 
                 165                170                175
Ile Tyr His Ser His Val Asp Ala Pro Lys Asp Ile Ala Ser Gly Leu 
             180                185                190
Ile Gly Pro Leu Ile Leu Cys Lys Lys Gly Ser Leu His Lys Glu Lys 
         195                200                205
Glu Glu Asn Ile Asp Gln Glu Phe Val Leu Met Phe Ser Val Val Asp 
     210                215                220
Glu Asn Leu Ser Trp Tyr Leu Glu Asp Asn Ile Lys Thr Phe Cys Ser 
 225                230                235                240
Glu Pro Glu Lys Val Asp Lys Asp Asn Glu Asp Phe Gln Glu Ser Asn 
                 245                250                255
Arg Met Tyr Ser Ile Asn Gly Tyr Thr Phe Gly Ser Leu Pro Gly Leu 
             260                265                270
Ser Met Cys Ala Glu Asp Arg Val Lys Trp Tyr Leu Phe Gly Met Gly 
         275                280                285
Asn Glu Val Asp Val His Ser Glu Leu Phe His Gly Gln Ala Leu Thr 
     290                295                300
Ser Lys Asn Tyr His Thr Asp Ile Ile Asn Leu Phe Pro Ala Thr Leu 
 305                310                315                320
Ile Asp Val Ser Met Val Ala Gln Asn Pro Gly Val Trp Met Leu Ser 
                 325                330                335
Cys Gln Asn Leu Asn His Leu Lys Ala Gly Leu Gln Ala Phe Phe Gln 
             340                345                350
Val Arg Asp Cys Asn Lys Pro Ser Pro Asp Asp Asp Ile Gln Asp Arg 
         355                360                365
His Val Arg His Tyr Tyr Ile Ala Ala Glu Glu Thr Ile Trp Asp Tyr 
     370                375                380
Ala Pro Ser Gly Thr Asp Thr Phe Thr Gly Glu Asn Phe Thr Ser Leu 
 385                390                395                400
Gly Ser Asp Ser Arg Val Phe Phe Glu Gln Gly Ala Thr Arg Ile Gly 
                 405                410                415
Gly Ser Tyr Lys Lys Leu Val Tyr Arg Glu Tyr Thr Asp Asp Ser Phe 
             420                425                430
Thr Asn Arg Lys Glu Arg Gly Pro Asp Glu Glu His Leu Gly Ile Leu 
         435                440                445
Gly Pro Val Ile Trp Ala Glu Val Gly Asp Ile Ile Arg Val Thr Phe 
     450                455                460
His Asn Lys Gly Gln Phe Pro Leu Ser Ile Gln Pro Met Gly Val Arg 
 465                470                475                480
Phe Thr Lys Glu Asn Glu Gly Thr Tyr Tyr Gly Pro Asp Gly Arg Ser 
                 485                490                495
Ser Lys Gln Ala Ser His Val Ala Pro Lys Glu Thr Phe Thr Tyr Glu 
             500                505                510
Trp Thr Val Pro Lys Glu Met Gly Pro Thr Tyr Ala Asp Pro Val Cys 
         515                520                525
Leu Ser Lys Met Tyr Tyr Ser Gly Val Asp Leu Thr Lys Asp Ile Phe 
     530                535                540
Thr Gly Leu Ile Gly Pro Met Lys Ile Cys Lys Lys Gly Ser Leu Leu 
 545                550                555                560
Ala Asp Gly Arg Gln Lys Asp Val Asp Lys Glu Phe Tyr Leu Phe Ala 
                 565                570                575
Thr Val Phe Asp Glu Asn Glu Ser Leu Leu Leu Asp Asp Asn Ile Arg 
             580                585                590
Met Phe Thr Thr Ala Pro Glu Asn Val Asp Lys Glu Asp Glu Asp Phe 
         595                600                605
Gln Glu Ser Asn Lys Met His Ser Met Asn Gly Phe Met Tyr Gly Asn 
     610                615                620
Leu Pro Gly Leu Asn Met Cys Leu Gly Glu Ser Ile Val Trp Tyr Leu 
 625                630                635                640
Phe Ser Ala Gly Asn Glu Ala Asp Val His Gly Ile Tyr Phe Ser Gly 
                 645                650                655
Asn Thr Tyr Leu Ser Lys Gly Glu Arg Arg Asp Thr Ala Asn Leu Phe 
             660                665                670
Pro His Lys Ser Leu Thr Leu Leu Met Thr Pro Asp Thr Glu Gly Ser 
         675                680                685
Phe Asp Val Glu Cys Leu Thr Thr Asp His Tyr Thr Gly Gly Met Lys 
     690                695                700
Gln Lys Tyr Thr Val Asn Gln Cys Lys Gly Gln Phe Glu Asp Val Thr 
 705                710                715                720
Leu Tyr Gln Gly Glu Arg Thr Tyr Tyr Ile Ala Ala Val Glu Val Glu 
                 725                730                735
Trp Asp Tyr Ser Pro Ser Arg Asp Trp Glu Met Glu Leu His His Leu 
             740                745                750
Gln Glu Gln Asn Val Ser Asn Ala Phe Leu Asp Lys Glu Glu Phe Phe 
         755                760                765
Ile Gly Ser Lys Tyr Lys Lys Val Val Tyr Arg Glu Phe Thr Asp Ser 
     770                775                780
Thr Phe Arg Glu Gln Val Lys Arg Arg Ala Glu Glu Glu His Leu Gly 
 785                790                795                800
Met Leu Gly Pro Leu Ile His Ala Asp Val Gly Ala Lys Val Lys Val 
                 805                810                815
Val Phe Lys Asn Met Ala Thr Arg Pro Tyr Ser Ile His Ala His Gly 
             820                825                830
Val Lys Thr Lys Ser Ser Thr Val Ala Pro Thr Leu Pro Gly Glu Val 
         835                840                845
Arg Thr Tyr Ile Trp Gln Ile Pro Glu Arg Ser Gly Ala Gly Thr Glu 
     850                855                860
Asp Ser Pro Cys Ile Pro Trp Ala Tyr Tyr Ser Thr Val Asp Arg Val 
 865                870                875                880
Lys Asp Leu Tyr Ser Gly Leu Ile Gly Pro Leu Ile Val Cys Arg Lys 
                 885                890                895
Ser Tyr Val Lys Val Phe Asn Pro Lys Lys Lys Met Glu Phe Ser Leu 
             900                905                910
Leu Phe Leu Val Phe Asp Glu Asn Glu Ser Trp Tyr Leu Asp Asp Asn 
         915                920                925
Ile Asn Thr Tyr Pro Asp His Pro Glu Lys Asp Asn Lys Asp Asn Glu 
     930                935                940
Glu Phe Ile Glu Ser Asn Lys Met His Ala Ile Asn Gly Lys Met Phe 
 945                950                955                960
Gly Asn Leu Gln Gly Leu Thr Met His Val Gly Asp Glu Val Asn Trp 
                 965                970                975
Tyr Val Met Ala Met Gly Asn Glu Ile Asp Leu His Thr Val His Phe 
             980                985                990
His Gly His Ser Phe Gln Tyr Lys His Arg Gly Ile His Ser Ser Asp 
         995                1000                1005
Val Phe Asp Phe Phe Pro Gly Thr Tyr Gln Thr Leu Glu Met Phe Pro 
     1010                1015                1020
Gln Thr Pro Gly Thr Trp Leu Leu His Cys His Val Thr Asp His Ile 
 1025                1030                1035                1040
His Ala Gly Met Val Thr Thr Tyr Thr Val Leu Pro Asn Gln Glu Thr 
                 1045                1050                1055
Lys Ser Gly 
             1060



<210> 3198
<211> 3321
<212> DNA
<213> Homo sapiens
<308> M13699
<400> 3198

atgaagatt  tgatacttg  tatttttct  tttttatgt  gtaccccag  ctgggcgaa  60
gaaaagcat  attacattg  aattattga  acgacttgg  attatgcct  tgaccatgg  120
gaaaagaaa  ttatttctg  tgacacgga  cattccaat  tctatcttc  aaatggccc  180
gatagaatt  ggagactat  taagaaggc  ctttatctt  agtacacag  tgaaacctt  240
aggacaact  tagaaaaac  ggtctggct  gggttttta  gccctatta  caaagctga  300
actggagat  aagtttatg  acacttaaa  aaccttgcc  ctaggccct  cacctttca  360
tcacatgga  taacttact  taaggaaca  gagggggcc  tctaccctg  taacaccac  420
gattttcaa  gagcagatg  caaagtata  ccaggagag  agtatacat  catgttgct  480
gccactgaa  aacaaagtc  tggggaagg  gatggcaat  gtgtgacta  gatttacca  540
tcccacatt  atgctccaa  agatattgc  tcaggactc  tcggacctt  aataatctg  600
aaaaaagat  ctctagata  agaaaaaga  aaacatatt  accgagaat  tgtggtgat  660
ttttctgtg  tggatgaaa  tttcagctg  tacctagaa  acaacatta  aacctactg  720
tcagaacca  agaaagttg  caaagacaa  gaagacttc  aggagagta  cagaatgta  780
tctgtgaat  gatacactt  tggaagtct  ccaggactc  ccatgtgtg  tgaagacag  840
gtaaaatgg  acctttttg  tatgggtaa  gaagttgat  tgcacgcag  tttctttca  900
gggcaagca  tgactaaca  gaactaccg  attgacaca  tcaacctct  tcctgctac  960
ctgtttgat  cttatatgg  ggcccagaa  cctggagaa  ggatgctca  ctgtcagaa  1020
ctaaaccat  tgaaagccg  tttgcaagc  tttttccag  tccaggagt  taacaagtc  1080
tcatcaaag  ataatatcc  tgggaagca  gttagacac  actacattg  cgctgagga  1140
atcatctgg  actatgctc  ctctggtat  gacatcttc  ctaaagaaa  cttaacagc  1200
cctggaagt  actcagcgg  gttttttga  caaggtacc  caagaattg  aggctctta  1260
aaaaagctg  tttatcgtg  gtacacaga  gcctccttc  caaatcgaa  ggagagagg  1320
cctgaagaa  agcatcttg  catcctggg  cctgtcatt  gggcagagg  gggagacac  1380
atcagagta  ccttccata  caaaggagc  tatcccctc  gtattgagc  gattggggt  1440
agattcaat  agaacaacg  gggcacata  tattcccca  attacaacc  ccagagcag  1500
agtgtgcct  cttcagcct  ccatgtggc  cccacagaa  cattcacct  tgaatggac  1560
gtccccaaa  aagtaggac  cactaatgc  gatcctgtg  gtctagcta  gatgtatta  1620
tctgctgtg  atcccacta  agatatatt  actgggctt  ttgggccaa  gaaaatatg  1680
aagaaagga  gtttacatg  aaatgggag  cagaaagat  tagacaagg  attctattt  1740
tttcctaca  tatttgatg  gaatgagag  ttactcctg  aagataata  tagaatgtt  1800
acaactgca  ctgatcagg  ggataagga  gatgaagac  ttcaggaat  taataaaat  1860
cactccatg  atggattca  gtatgggaa  cagccgggt  tcactatgt  caaaggaga  1920
tcggtcgtg  ggtacttat  cagcgccgg  aatgaggcc  atgtacatg  aatatactt  1980
tcaggaaac  catatctgt  gagaggaga  cggagagac  cagcaaacc  cttccctca  2040
acaagtctt  cgctccaca  gtggcctga  acagagggg  cttttaatg  tgaatgcct  2100
acaactgat  attacacag  cggcatgaa  caaaaatat  ctgtgaacc  atgcaggcg  2160
cagtctgag  attccacct  ctacctggg  gagaggaca  actatatcg  agcagtgga  2220
gtggaatgg  attattccc  acaaaggga  tgggaaaag  agctgcatc  tttacaaga  2280
cagaatgtt  caaatgcat  tttagataa  ggagagttt  acataggct  aaagtacaa  2340
aaagttgtg  atcggcagt  tactgatag  acattccgt  ttccagtgg  gagaaaagc  2400
gaagaagaa  atctgggaa  tctaggtcc  caacttcat  cagatgttg  agacaaagt  2460
aaaattatc  ttaaaaaca  ggccacaag  ccctactca  tacatgccc  tggggtaca  2520
acagagagt  ctacagtta  tccaacatt  ccaggtgaa  ctctcactt  cgtatggaa  2580
atcccagaa  gatctggag  tggaacaga  gattctgct  gtattccat  ggcttatta  2640
tcaactgtg  atcaagtta  ggacctcta  agtggatta  ttggccccc  gattgtttg  2700
cgaagacct  acttgaaag  attcaatcc  agaaggaag  tggaatttg  ccttctgtt  2760
ctagttttt  atgagaatg  atcttggta  ttagatgac  acatcaaaa  atactctga  2820
caccccgag  aagtaaaca  agatgatga  gaattcata  aaagcaata  aatgcatgc  2880
attaatgga  gaatgtttg  aaacctaca  ggcctcaca  tgcacgtgg  agatgaagt  2940
aactggtat  tgatgggaa  gggcaatga  atagactta  acactgtac  ttttcacgg  3000
catagcttc  aatacaagc  caggggagt  tatagttct  atgtctttg  cattttccc  3060
ggaacatac  aaaccctag  aatgtttcc  agaacacct  gaatttggt  actccactg  3120
catgtgacc  accacattc  tgctggaat  gaaaccact  acaccgttc  acaaaatga  3180
gacaccaaa  ctggctgaa  gaaataaat  ggtgataag  ggaaaaaag  gaaaaacca  3240
tgattcata  caatgtatg  gaaagtgta  aatagaatg  tactttgga  tgactataa  3300
cattaaaag  gactggagc  t  3321



<210> 3199
<211> 1065
<212> PRT
<213> Homo sapiens
<308> P00450
<400> 3199

Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
  1               5                  10                  15
Ala Trp Ala Lys Glu Lys His Tyr Tyr Ile Gly Ile Ile Glu Thr Thr 
             20                  25                  30
Trp Asp Tyr Ala Ser Asp His Gly Glu Lys Lys Leu Ile Ser Val Asp 
         35                  40                  45
Thr Glu His Ser Asn Ile Tyr Leu Gln Asn Gly Pro Asp Arg Ile Gly 
     50                  55                  60
Arg Leu Tyr Lys Lys Ala Leu Tyr Leu Gln Tyr Thr Asp Glu Thr Phe 
 65                  70                  75                  80
Arg Thr Thr Ile Glu Lys Pro Val Trp Leu Gly Phe Leu Gly Pro Ile 
                 85                  90                  95
Ile Lys Ala Glu Thr Gly Asp Lys Val Tyr Val His Leu Lys Asn Leu 
             100                105                110
Ala Ser Arg Pro Tyr Thr Phe His Ser His Gly Ile Thr Tyr Tyr Lys 
         115                120                125
Glu His Glu Gly Ala Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln Arg 
     130                135                140
Ala Asp Asp Lys Val Tyr Pro Gly Glu Gln Tyr Thr Tyr Met Leu Leu 
 145                150                155                160
Ala Thr Glu Glu Gln Ser Pro Gly Glu Gly Asp Gly Asn Cys Val Thr 
                 165                170                175
Arg Ile Tyr His Ser His Ile Asp Ala Pro Lys Asp Ile Ala Ser Gly 
             180                185                190
Leu Ile Gly Pro Leu Ile Ile Cys Lys Lys Asp Ser Leu Asp Lys Glu 
         195                200                205
Lys Glu Lys His Ile Asp Arg Glu Phe Val Val Met Phe Ser Val Val 
     210                215                220
Asp Glu Asn Phe Ser Trp Tyr Leu Glu Asp Asn Ile Lys Thr Tyr Cys 
 225                230                235                240
Ser Glu Pro Glu Lys Val Asp Lys Asp Asn Glu Asp Phe Gln Glu Ser 
                 245                250                255
Asn Arg Met Tyr Ser Val Asn Gly Tyr Thr Phe Gly Ser Leu Pro Gly 
             260                265                270
Leu Ser Met Cys Ala Glu Asp Arg Val Lys Trp Tyr Leu Phe Gly Met 
         275                280                285
Gly Asn Glu Val Asp Val His Ala Ala Phe Phe His Gly Gln Ala Leu 
     290                295                300
Thr Asn Lys Asn Tyr Arg Ile Asp Thr Ile Asn Leu Phe Pro Ala Thr 
 305                310                315                320
Leu Phe Asp Ala Tyr Met Val Ala Gln Asn Pro Gly Glu Trp Met Leu 
                 325                330                335
Ser Cys Gln Asn Leu Asn His Leu Lys Ala Gly Leu Gln Ala Phe Phe 
             340                345                350
Gln Val Gln Glu Cys Asn Lys Ser Ser Ser Lys Asp Asn Ile Arg Gly 
         355                360                365
Lys His Val Arg His Tyr Tyr Ile Ala Ala Glu Glu Ile Ile Trp Asn 
     370                375                380
Tyr Ala Pro Ser Gly Ile Asp Ile Phe Thr Lys Glu Asn Leu Thr Ala 
 385                390                395                400
Pro Gly Ser Asp Ser Ala Val Phe Phe Glu Gln Gly Thr Thr Arg Ile 
                 405                410                415
Gly Gly Ser Tyr Lys Lys Leu Val Tyr Arg Glu Tyr Thr Asp Ala Ser 
             420                425                430
Phe Thr Asn Arg Lys Glu Arg Gly Pro Glu Glu Glu His Leu Gly Ile 
         435                440                445
Leu Gly Pro Val Ile Trp Ala Glu Val Gly Asp Thr Ile Arg Val Thr 
     450                455                460
Phe His Asn Lys Gly Ala Tyr Pro Leu Ser Ile Glu Pro Ile Gly Val 
 465                470                475                480
Arg Phe Asn Lys Asn Asn Glu Gly Thr Tyr Tyr Ser Pro Asn Tyr Asn 
                 485                490                495
Pro Gln Ser Arg Ser Val Pro Pro Ser Ala Ser His Val Ala Pro Thr 
             500                505                510
Glu Thr Phe Thr Tyr Glu Trp Thr Val Pro Lys Glu Val Gly Pro Thr 
         515                520                525
Asn Ala Asp Pro Val Cys Leu Ala Lys Met Tyr Tyr Ser Ala Val Asp 
     530                535                540
Pro Thr Lys Asp Ile Phe Thr Gly Leu Ile Gly Pro Met Lys Ile Cys 
 545                550                555                560
Lys Lys Gly Ser Leu His Ala Asn Gly Arg Gln Lys Asp Val Asp Lys 
                 565                570                575
Glu Phe Tyr Leu Phe Pro Thr Val Phe Asp Glu Asn Glu Ser Leu Leu 
             580                585                590
Leu Glu Asp Asn Ile Arg Met Phe Thr Thr Ala Pro Asp Gln Val Asp 
         595                600                605
Lys Glu Asp Glu Asp Phe Gln Glu Ser Asn Lys Met His Ser Met Asn 
     610                615                620
Gly Phe Met Tyr Gly Asn Gln Pro Gly Leu Thr Met Cys Lys Gly Asp 
 625                630                635                640
Ser Val Val Trp Tyr Leu Phe Ser Ala Gly Asn Glu Ala Asp Val His 
                 645                650                655
Gly Ile Tyr Phe Ser Gly Asn Thr Tyr Leu Trp Arg Gly Glu Arg Arg 
             660                665                670
Asp Thr Ala Asn Leu Phe Pro Gln Thr Ser Leu Thr Leu His Met Trp 
         675                680                685
Pro Asp Thr Glu Gly Thr Phe Asn Val Glu Cys Leu Thr Thr Asp His 
     690                695                700
Tyr Thr Gly Gly Met Lys Gln Lys Tyr Thr Val Asn Gln Cys Arg Arg 
 705                710                715                720
Gln Ser Glu Asp Ser Thr Phe Tyr Leu Gly Glu Arg Thr Tyr Tyr Ile 
                 725                730                735
Ala Ala Val Glu Val Glu Trp Asp Tyr Ser Pro Gln Arg Glu Trp Glu 
             740                745                750
Lys Glu Leu His His Leu Gln Glu Gln Asn Val Ser Asn Ala Phe Leu 
         755                760                765
Asp Lys Gly Glu Phe Tyr Ile Gly Ser Lys Tyr Lys Lys Val Val Tyr 
     770                775                780
Arg Gln Tyr Thr Asp Ser Thr Phe Arg Val Pro Val Glu Arg Lys Ala 
 785                790                795                800
Glu Glu Glu His Leu Gly Ile Leu Gly Pro Gln Leu His Ala Asp Val 
                 805                810                815
Gly Asp Lys Val Lys Ile Ile Phe Lys Asn Met Ala Thr Arg Pro Tyr 
             820                825                830
Ser Ile His Ala His Gly Val Gln Thr Glu Ser Ser Thr Val Thr Pro 
         835                840                845
Thr Leu Pro Gly Glu Thr Leu Thr Tyr Val Trp Lys Ile Pro Glu Arg 
     850                855                860
Ser Gly Ala Gly Thr Glu Asp Ser Ala Cys Ile Pro Trp Ala Tyr Tyr 
 865                870                875                880
Ser Thr Val Asp Gln Val Lys Asp Leu Tyr Ser Gly Leu Ile Gly Pro 
                 885                890                895
Leu Ile Val Cys Arg Arg Pro Tyr Leu Lys Val Phe Asn Pro Arg Arg 
             900                905                910
Lys Leu Glu Phe Ala Leu Leu Phe Leu Val Phe Asp Glu Asn Glu Ser 
         915                920                925
Trp Tyr Leu Asp Asp Asn Ile Lys Thr Tyr Ser Asp His Pro Glu Lys 
     930                935                940
Val Asn Lys Asp Asp Glu Glu Phe Ile Glu Ser Asn Lys Met His Ala 
 945                950                955                960
Ile Asn Gly Arg Met Phe Gly Asn Leu Gln Gly Leu Thr Met His Val 
                 965                970                975
Gly Asp Glu Val Asn Trp Tyr Leu Met Gly Met Gly Asn Glu Ile Asp 
             980                985                990
Leu His Thr Val His Phe His Gly His Ser Phe Gln Tyr Lys His Arg 
         995                1000                1005
Gly Val Tyr Ser Ser Asp Val Phe Asp Ile Phe Pro Gly Thr Tyr Gln 
     1010                1015                1020
Thr Leu Glu Met Phe Pro Arg Thr Pro Gly Ile Trp Leu Leu His Cys 
 1025                1030                1035                1040
His Val Thr Asp His Ile His Ala Gly Met Glu Thr Thr Tyr Thr Val 
                 1045                1050                1055
Leu Gln Asn Glu Asp Thr Lys Ser Gly 
             1060                1065



<210> 3200
<211> 2248
<212> DNA
<213> Rattus norvegicus
<308> L34262
<400> 3200

atggcgtcg  ccggttacc  gaggctgct  gctgcggct  tgcttcctt  gtgttgcgc  60
gcctgggcc  tgggacatc  ggacccacc  tctccacca  cgctggtga  ctggcatgg  120
atgggggac  gctgctgta  ccccatgag  atgggtagc  ttaaaaaga  ggttgaaaa  180
gaaatacca  ggatttacg  cctgtctct  gagattggg  agaacatgg  ggaggatgt  240
gagaacagc  tcttcttga  tgtcaacct  caagtcgga  tggcatgtc  gattctgga  300
aaggatcct  agttgcaac  cggatacaa  gctattggc  tctcccagg  aggccagtt  360
ctgagggca  tggctcaga  atgcccaac  cctcccatg  tgaccctga  ctcagttgg  420
ggacaacat  aaggtgtct  tggactccc  cgatgccca  gagagagtt  tcatatctg  480
gacttcatc  ggaagtcac  taacgctgg  gcttactcc  aagttgtgc  agaacgcct  540
gtgcaagca  agtactggc  tgaccccat  aaggaggaa  tgtaccgaa  ctgcagcat  600
ttcttggca  acataaatc  agagaggca  atcaatgag  cctataagg  gaacctgat  660
gccctcaag  agtttgtga  ggtgaaatt  tttaacgat  ccatcgtgg  ccctgtaga  720
tctgagtgg  ttggatttt  cagaagtgg  caagctaag  aaaccattc  cctccagga  780
accactcta  acacagagg  ccgcctggg  ctaaagaaa  tggacaaag  aggaaagct  840
gtgtttctg  ctaaggaag  agaccacct  caaatatct  aagagtggt  tacagccca  900
atcatacct  ttcttaagt  aagcccttg  actttgcag  agagtttat  acaccacag  960
tcttccaaa  tccagtttg  aaccagtcc  tctctcgtg  tatcatcta  catgccctg  1020
ttggaaaga  ctaagatct  aatcttatc  tttgccgcc  gctatcacc  tatggtgtt  1080
aattcaagt  taattagct  gtaaccgtg  agactgctt  acaaccatg  gatatggtc  1140
agctctctt  tacggaagg  gagtctgct  ttgcagatc  gcaattgtg  ctaagtgaa  1200
tgaagtgaa  cagagagac  agctctgag  gtaaaaccc  tacaaattt  gagcaaata  1260
aagcctcat  gtatccagt  ctgagatgt  cacacaagc  atttctcaa  attgctgtg  1320
gggccatgc  tgtttctac  tcatttctt  aagctgttt  cctatttta  tgttgccct  1380
tagtggcac  tagcagtca  tccacaagc  taccaacat  ccccctcag  gctcacctt  1440
tatccttaa  cctcagtca  caaaagggg  atccaccag  agggttgct  aggagagga  1500
atgtccttt  tcttttctt  ccttttttg  gacagggtt  cactcactt  ttaacccta  1560
ctggcctgc  attcactat  tagagcaga  tggccttga  ctcagtcac  gaaatcacc  1620
gcccctctg  cttctgagt  ctgggatta  aggcatgca  ccccacccc  tacagcaat  1680
tgtgtctta  acaccatgg  tagtgcggg  gtggagaag  gaaaactag  tggctggtc  1740
tgccactgc  ctcttggct  actgtcctt  atattacaa  tagcgtaaa  gtcacttac  1800
ctactgcaa  caatgggag  aacagtctg  aaagatgga  cttgacgat  ctaccctac  1860
tcctatttg  cagcatgcg  ccaactgct  ctgactggg  tcaagaaaa  gactaaaga  1920
taaaaatca  cacatatta  actgatgat  attctgaca  ttaaagaaa  acaacactg  1980
tccaccatt  cctacattt  aacatggac  ccttagccc  catcctgaa  agatcccag  2040
atgttctag  tgattccta  agagactgg  ttggagaaa  gactgtttt  gtcaaagta  2100
cattagccc  gcagaatcc  cccactgct  gtttttcct  ttcctttct  aaacctagt  2160
aaataaaag  atgagggtt  tggggagga  gtgggagga  ctgaaaata  ctttgaggt  2220
gtcttaaaa  aataaagaa  agtttctt  2248



<210> 3201
<211> 306
<212> PRT
<213> Rattus norvegicus
<308> P45479
<400> 3201

Met Ala Ser Pro Gly Tyr Arg Arg Leu Leu Ala Ala Ala Leu Leu Pro 
  1               5                  10                  15
Trp Cys Cys Ala Ala Trp Ala Leu Gly His Leu Asp Pro Pro Ser Pro 
             20                  25                  30
Pro Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
         35                  40                  45
Met Ser Met Gly Ser Ile Lys Lys Met Val Glu Lys Glu Ile Pro Gly 
     50                  55                  60
Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Asn Met Val Glu Asp Val 
 65                  70                  75                  80
Glu Asn Ser Phe Phe Leu Asn Val Asn Leu Gln Val Gly Met Ala Cys 
                 85                  90                  95
Gln Ile Leu Glu Lys Asp Pro Lys Leu Gln His Gly Tyr Asn Ala Ile 
             100                105                110
Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
         115                120                125
Pro Thr Pro Pro Met Met Thr Leu Ile Ser Val Gly Gly Gln His Gln 
     130                135                140
Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
 145                150                155                160
Asp Phe Ile Arg Lys Ser Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                 165                170                175
Gln Glu Arg Leu Val Gln Ala Gln Tyr Trp His Asp Pro Ile Lys Glu 
             180                185                190
Glu Val Tyr Arg Asn Cys Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
         195                200                205
Arg His Ile Asn Glu Ser Tyr Lys Glu Asn Leu Met Ala Leu Lys Lys 
     210                215                220
Phe Val Met Val Lys Phe Phe Asn Asp Ser Ile Val Asp Pro Val Asp 
 225                230                235                240
Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                 245                250                255
Pro Leu Gln Glu Thr Thr Leu Tyr Thr Glu Asp Arg Leu Gly Leu Lys 
             260                265                270
Lys Met Asp Lys Ala Gly Lys Leu Val Phe Leu Ala Lys Glu Gly Asp 
         275                280                285
His Leu Gln Ile Ser Lys Glu Trp Phe Thr Ala His Ile Ile Pro Phe 
     290                295                300
Leu Lys 
 305



<210> 3202
<211> 2292
<212> DNA
<213> Homo sapiens
<308> XM_029842
<400> 3202

ccggagtct  gcgcccgcg  tcatgtgac  cagcgaaga  ggcgtcgcc  ggctgcctg  60
ggctcttgg  tgtggctct  ctgccatgg  cctgcgctt  tcgggcgct  cagcatctg  120
acccgccgg  gccgctgcc  ttggtgatc  ggcatggga  gggagacag  tgttgcaat  180
ccttaagca  gggtgctat  aaaaaaatg  tggagaaga  aatacctgg  atttacgtc  240
tatctttag  gattgggaa  accctgatg  aggacgtgg  gaacagctt  ttcttgaat  300
tcaattccc  agtaacaac  gtgtgtcag  cacttgcta  ggatcctaa  ttgcagcaa  360
gctacaatg  tatgggatt  tcccaggga  gccaatttc  gagggcagt  gctcagaga  420
gcccttcac  tcccatgat  aatctgatc  cggttgggg  acaacatca  ggtgttttt  480
gactccctc  atgcccagg  gagagctct  acatctgtg  cttcatccg  aaaacactg  540
atgctgggg  gtactccaa  gttgttcag  aacgcctcg  gcaagccga  tactggcat  600
accccataa  ggaggatgt  tatcgcaac  acagcatct  cttggcaga  ataaatcag  660
agcggggta  caatgagtc  tacaagaaa  acctgatgg  cctgaagaa  tttgtgatg  720
tgaaattcc  caatgattc  attgtggac  ctgtagatt  ggagtggtt  ggattttac  780
gaagtggcc  agccaagga  accattccc  tacaggaga  ctccctgta  acacaggac  840
gcctggggc  aaaggaaat  gacaatgca  gacagctag  gtttctggc  acagaaggg  900
accatcttc  gttgtctga  gaatggttt  atgcccaca  cataccatt  cttggatga  960
acccgtata  ttcacaata  agctcaggg  gcccctaac  cttccaaac  acatgggag  1020
cagtttcct  catgcccaa  cctgagctc  gatccagct  gcaactaat  cttctatca  1080
ctaacatgc  ctacttgga  agatctaag  tctgaatct  atcctttgc  atcttctgt  1140
accatatgg  gttgaatgc  agtttaatt  ccatggaga  tgttttaca  acttttgat  1200
tggtcaagt  cagttttag  aaagggagt  tgttccaga  cagtgccag  actgtgccc  1260
ggcccaaag  agacaacta  ctaaagtag  gagatagat  ctaagggca  acatttttc  1320
aagtcttgc  atatttcaa  caaagaggt  cccaggcct  aggtactca  ataaatgct  1380
tgttttgct  gtgatttaa  cagtgcttg  aaaaatctt  cttggctat  tctgcatca  1440
ttcttaagg  tgccttcct  tctcagtac  ttgccctct  tgctatcat  ttatcatca  1500
ttattagac  aatcccact  gcctacagt  ttgcttctg  agcacccac  ttgtctcct  1560
aggtagtga  gaattagtt  ctgtcacaa  aggagggaa  tagcaccca  attaagttg  1620
ttaagagag  aaatgtaca  cttgtataa  ttagggagc  aagaaaatg  aggcgcgaa  1680
gtgaaaagt  aggcagcta  ttcttccta  tccattctc  accaacctg  cctttctta  1740
tatgactag  ggtcttgat  ctagagtca  cttactctg  tgctggctt  agcagagaa  1800
aggaggaac  atatgaaaa  gatcaggct  tctgacttc  atccccaaa  cacatttac  1860
agcatactc  aaactgttt  tgatgtgtt  catgagaaa  ggattgttt  ctcaaaaag  1920
ttggaaaat  ctacacact  cctttctcc  tctggagat  aacccacat  agagtgtct  1980
aggactcct  agaattcct  ttacagtaa  caaaactaa  gtaatctac  atttcctac  2040
ctatttgag  atggaaatc  tagtcccca  tctgtgaaa  cttaacgct  tttggaaga  2100
atttctgta  catgtcagt  tggagaaat  atgagctac  ccttgatga  agaaccgtg  2160
tggtgctgc  aagtttagc  attatggtt  ttcctttct  tctcttaag  cttattctt  2220
aactaaaag  tgaggatta  gagcaagaa  ttggggggg  tgtgaaaat  attttatga  2280
gttgtctaa  at  2292



<210> 3203
<211> 306
<212> PRT
<213> Homo sapiens
<308> XP_029842
<400> 3203

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
  1               5                  10                  15
Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
             20                  25                  30
Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
         35                  40                  45
Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
     50                  55                  60
Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
 65                  70                  75                  80
Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                 85                  90                  95
Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
             100                105                110
Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
         115                120                125
Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
     130                135                140
Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
 145                150                155                160
Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                 165                170                175
Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
             180                185                190
Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
         195                200                205
Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
     210                215                220
Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
 225                230                235                240
Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                 245                250                255
Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
             260                265                270
Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
         275                280                285
His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
     290                295                300
Leu Gly 
 305



<210> 3204
<211> 1731
<212> DNA
<213> Rattus norvegicus
<308> L34821
<400> 3204

gttggtggt  ctgccgacc  ccacgccga  ctgctccgc  gggacagct  tgtgggcgg  60
cgctggctt  caacccctg  caccttccc  gtgtatgac  cggccagcg  cgccaagct  120
ggcaccgtg  ccgactgcg  ggtaccgga  gcccgcgct  ctgtgcgcg  cgcctacga  180
gccttcagc  gctggaaag  gatctcggt  aaggagagg  gctcattgc  ccgtaaatg  240
tacgactta  tgatacaaa  caaggacga  cttgccaag  tcataacag  tgagagtgg  300
aagccactg  aagaggccc  gggagagat  ctgtattca  cgtttttcc  ggagtggtt  360
tcagaggaa  ctcgccgtg  ttatggaga  atcatctat  cctctgcca  agataagcg  420
ggactggtc  tcaagcagc  cgttggtgt  gcgtccatc  tcacaccgt  gaattttcc  480
agtgccatg  tcacccgga  agtgggggc  gccctggca  ctggctgca  tgtggtggt  540
aaacctgct  aagatacac  ctattctgc  ctggccctg  ctcagcttg  aaaccaggc  600
ggaatccct  caggtgtct  taatgtcat  ccctgctct  gaaccaagg  caaggaagt  660
ggagaggtg  tgtgtactg  tcccctcgt  tccaaaatc  cctttactg  ctcaacggc  720
acgggaaag  tcctgctgc  tcatgcagc  aattctgtg  agcgtgtct  catggagct  780
ggtggcctc  ccccattca  tgtctttga  agtgccaac  tggaccagg  tgtcgcagg  840
gcaatggca  ctaaattta  gaatgctgg  cagacttgc  tttgctcaa  cagattctt  900
gtacaacgg  gtatccacg  ttcctttgt  acgaagttt  cagaagcga  gaagaaaag  960
ctgcgtgta  gtaacggat  tgaggaagg  acaactcaa  ggccattaa  taatgagaa  1020
gctgtagaa  aggtagaga  gcatgtgaa  gacgcagtt  ccaaagggg  cacggttgt  1080
acaggcggg  agcgacacc  gagcggagg  aatttcttc  aacccaccc  gctcagcaa  1140
gtcaccagg  acatgctct  catcaccga  gagaccttt  ggcccgtgg  gccagtcat  1200
aagttcgat  aagaggaag  ggctgtcgc  atcgcaaat  cagctgatg  tggattggc  1260
ggttacttt  actctcaag  cccagccca  atctggaga  tggcggagc  gctggaggt  1320
ggcatggtt  gcgtgaacg  aggactgat  tcttcagtg  agtgccctt  tggtggggt  1380
aaacagtcg  gccttgggc  agaagggtc  aagtatggc  ttgacgaat  tctagaggt  1440
aaatatgtg  gttatggag  cttgtaggg  tctcacttc  ttaataaat  acctagatc  1500
atagggaca  tccatccat  tttttacaa  gaacaagta  gttatcaga  ttatgaatt  1560
ttaaaaatt  agccggtcc  gtcttagat  tacacccta  cccttccct  atctaacta  1620
gaaccaatg  acaccatat  cctgtggct  tgggtccca  ccagtgctg  gaccccagc  1680
caaccccac  gcctccata  aaagtacag  gtgagtgtt  acatgccct  t  1731



<210> 3205
<211> 488
<212> PRT
<213> Rattus norvegicus
<308> P51650
<400> 3205

Val Gly Gly Pro Ala Asp Leu His Ala Asp Leu Leu Arg Gly Asp Ser 
  1               5                  10                  15
Phe Val Gly Gly Arg Trp Leu Pro Thr Pro Ala Thr Phe Pro Val Tyr 
             20                  25                  30
Asp Pro Ala Ser Gly Ala Lys Leu Gly Thr Val Ala Asp Cys Gly Val 
         35                  40                  45
Pro Glu Ala Arg Ala Ala Val Arg Ala Ala Tyr Asp Ala Phe Ser Ser 
     50                  55                  60
Trp Lys Glu Ile Ser Val Lys Glu Arg Ser Ser Leu Leu Arg Lys Trp 
 65                  70                  75                  80
Tyr Asp Leu Met Ile Gln Asn Lys Asp Glu Leu Ala Lys Ile Ile Thr 
                 85                  90                  95
Ala Glu Ser Gly Lys Pro Leu Lys Glu Ala Gln Gly Glu Ile Leu Tyr 
             100                105                110
Ser Ala Phe Phe Leu Glu Trp Phe Ser Glu Glu Ala Arg Arg Val Tyr 
         115                120                125
Gly Asp Ile Ile Tyr Thr Ser Ala Lys Asp Lys Arg Gly Leu Val Leu 
     130                135                140
Lys Gln Pro Val Gly Val Ala Ser Ile Ile Thr Pro Trp Asn Phe Pro 
 145                150                155                160
Ser Ala Met Ile Thr Arg Lys Val Gly Ala Ala Leu Ala Ala Gly Cys 
                 165                170                175
Thr Val Val Val Lys Pro Ala Glu Asp Thr Pro Tyr Ser Ala Leu Ala 
             180                185                190
Leu Ala Gln Leu Ala Asn Gln Ala Gly Ile Pro Pro Gly Val Tyr Asn 
         195                200                205
Val Ile Pro Cys Ser Arg Thr Lys Ala Lys Glu Val Gly Glu Val Leu 
     210                215                220
Cys Thr Asp Pro Leu Val Ser Lys Ile Ser Phe Thr Gly Ser Thr Ala 
 225                230                235                240
Thr Gly Lys Ile Leu Leu His His Ala Ala Asn Ser Val Lys Arg Val 
                 245                250                255
Ser Met Glu Leu Gly Gly Leu Ala Pro Phe Ile Val Phe Asp Ser Ala 
             260                265                270
Asn Val Asp Gln Ala Val Ala Gly Ala Met Ala Ser Lys Phe Arg Asn 
         275                280                285
Ala Gly Gln Thr Cys Val Cys Ser Asn Arg Phe Leu Val Gln Arg Gly 
     290                295                300
Ile His Asp Ser Phe Val Thr Lys Phe Ala Glu Ala Met Lys Lys Ser 
 305                310                315                320
Leu Arg Val Gly Asn Gly Phe Glu Glu Gly Thr Thr Gln Gly Pro Leu 
                 325                330                335
Ile Asn Glu Lys Ala Val Glu Lys Val Glu Lys His Val Asn Asp Ala 
             340                345                350
Val Ala Lys Gly Ala Thr Val Val Thr Gly Gly Lys Arg His Gln Ser 
         355                360                365
Gly Gly Asn Phe Phe Glu Pro Thr Leu Leu Ser Asn Val Thr Arg Asp 
     370                375                380
Met Leu Cys Ile Thr Glu Glu Thr Phe Gly Pro Val Ala Pro Val Ile 
 385                390                395                400
Lys Phe Asp Lys Glu Glu Glu Ala Val Ala Ile Ala Asn Ala Ala Asp 
                 405                410                415
Val Gly Leu Ala Gly Tyr Phe Tyr Ser Gln Asp Pro Ala Gln Ile Trp 
             420                425                430
Arg Val Ala Glu Gln Leu Glu Val Gly Met Val Gly Val Asn Glu Gly 
         435                440                445
Leu Ile Ser Ser Val Glu Cys Pro Phe Gly Gly Val Lys Gln Ser Gly 
     450                455                460
Leu Gly Arg Glu Gly Ser Lys Tyr Gly Ile Asp Glu Tyr Leu Glu Val 
 465                470                475                480
Lys Tyr Val Cys Tyr Gly Gly Leu 
                 485



<210> 3206
<211> 1071
<212> DNA
<213> Homo sapiens
<308> L34820
<400> 3206

cggaaggtg  gggccgccc  ggcagccgg  tgtactgtc  tggtgaagc  tgccgaaga  60
acgcccttc  ccgccctgg  cctggctga  cttgcaagc  aggctggga  tccttcagg  120
gtatacaat  ttattccct  ttctcgaaa  aatgccaag  aagtagggg  ggcaatttg  180
actgatcct  tggtgtcca  aatttcctt  actggttca  caactacag  aaagatcct  240
ttgcaccac  cagcaaact  tgtgaaaag  gtctctatg  agctgggcg  ccttgctcc  300
tttatagta  ttgacagtg  caacgtgga  caggctgta  caggggcca  ggcatctaa  360
tttaggaac  ctggacaga  ttgtgtttg  tcaaaccaa  tcttggtgc  aaggggcat  420
catgatgcc  ttgtaaaag  attcgccga  gccatgaag  agaacctgc  cgtaggtaa  480
ggatttgag  aaggaacta  tcagggccc  ttaattaat  aaaaagcgg  agaaaaggt  540
gagaaacag  tgaatgatg  cgtttctaa  ggtgccacc  ttgtgacag  tggaaaacg  600
caccaactt  gaaaaaatt  ctttgagcc  accctgctg  gcaatgtca  ccaggacat  660
ctgtgcact  atgaagaga  tttcgggcc  ctggcacca  ttatcaagt  cgatacaga  720
gaggaggct  tagcaatcg  taacgcagc  gatgttggg  tagcaggtt  tttttactc  780
caagaccca  cccagatct  gagagtggc  gagcagctg  aagtgggca  ggttggcgt  840
aacgaagga  taatttcct  tgtggagtg  ccttttggt  gagtgaagc  gtccggcct  900
gggcgagag  ggtccaagt  tggcattga  gagtatctg  aactcaagt  tgtgtgtta  960
gggggcttg  aggattctt  ggttcttta  aaaaattta  aaggagact  atctacata  1020
ataggtaca  gccatccat  attttaaat  aactaatag  ttttcagaa  t  1071



<210> 3207
<211> 535
<212> PRT
<213> Homo sapiens
<308> P51649
<400> 3207

Met Ala Thr Cys Ile Trp Leu Arg Ser Cys Gly Ala Arg Arg Leu Gly 
  1               5                  10                  15
Ser Thr Phe Pro Gly Cys Arg Leu Arg Pro Arg Ala Gly Gly Leu Val 
             20                  25                  30
Pro Ala Ser Gly Pro Ala Pro Gly Pro Ala Gln Leu Arg Cys Tyr Ala 
         35                  40                  45
Gly Arg Leu Ala Gly Leu Ser Ala Ala Leu Leu Arg Thr Asp Ser Phe 
     50                  55                  60
Val Gly Gly Arg Trp Leu Pro Ala Ala Ala Thr Phe Pro Val Gln Asp 
 65                  70                  75                  80
Pro Ala Ser Gly Ala Ala Leu Gly Met Val Ala Asp Cys Gly Val Arg 
                 85                  90                  95
Glu Ala Arg Ala Ala Val Arg Ala Ala Tyr Glu Ala Phe Cys Arg Trp 
             100                105                110
Arg Glu Val Ser Ala Lys Glu Arg Ser Ser Leu Leu Arg Lys Trp Tyr 
         115                120                125
Asn Leu Met Ile Gln Asn Lys Asp Asp Leu Ala Arg Ile Ile Thr Ala 
     130                135                140
Glu Ser Gly Lys Pro Leu Lys Glu Ala His Gly Glu Ile Leu Tyr Ser 
 145                150                155                160
Ala Phe Phe Leu Glu Trp Phe Ser Glu Glu Ala Arg Arg Val Tyr Gly 
                 165                170                175
Asp Ile Ile His Thr Pro Ala Lys Asp Arg Arg Ala Leu Val Leu Lys 
             180                185                190
Gln Pro Ile Gly Val Ala Ala Val Ile Thr Pro Trp Asn Phe Pro Ser 
         195                200                205
Ala Met Ile Thr Arg Lys Val Gly Ala Ala Leu Ala Ala Gly Cys Thr 
     210                215                220
Val Val Val Lys Pro Ala Glu Asp Thr Pro Phe Ser Ala Leu Ala Leu 
 225                230                235                240
Ala Glu Leu Ala Ser Gln Ala Gly Ile Pro Ser Gly Val Tyr Asn Val 
                 245                250                255
Ile Pro Cys Ser Arg Lys Asn Ala Lys Glu Val Gly Glu Ala Ile Cys 
             260                265                270
Thr Asp Pro Leu Val Ser Lys Ile Ser Phe Thr Gly Ser Thr Thr Thr 
         275                280                285
Gly Lys Ile Leu Leu His His Ala Ala Asn Ser Val Lys Arg Val Ser 
     290                295                300
Met Glu Leu Gly Gly Leu Ala Pro Phe Ile Val Phe Asp Ser Ala Asn 
 305                310                315                320
Val Asp Gln Ala Val Ala Gly Ala Met Ala Ser Lys Phe Arg Asn Thr 
                 325                330                335
Gly Gln Thr Cys Val Cys Ser Asn Gln Phe Leu Val Gln Arg Gly Ile 
             340                345                350
His Asp Ala Phe Val Lys Ala Phe Ala Glu Ala Met Lys Lys Asn Leu 
         355                360                365
Arg Val Gly Asn Gly Phe Glu Glu Gly Thr Thr Gln Gly Pro Leu Ile 
     370                375                380
Asn Glu Lys Ala Val Glu Lys Val Glu Lys Gln Val Asn Asp Ala Val 
 385                390                395                400
Ser Lys Gly Ala Thr Val Val Thr Gly Gly Lys Arg His Gln Leu Gly 
                 405                410                415
Lys Asn Phe Phe Glu Pro Thr Leu Leu Cys Asn Val Thr Gln Asp Met 
             420                425                430
Leu Cys Thr His Glu Glu Thr Phe Gly Pro Leu Ala Pro Val Ile Lys 
         435                440                445
Phe Asp Thr Glu Glu Glu Ala Ile Ala Ile Ala Asn Ala Ala Asp Val 
     450                455                460
Gly Leu Ala Gly Tyr Phe Tyr Ser Gln Asp Pro Ala Gln Ile Trp Arg 
 465                470                475                480
Val Ala Glu Gln Leu Glu Val Gly Met Val Gly Val Asn Glu Gly Leu 
                 485                490                495
Ile Ser Ser Val Glu Cys Pro Phe Gly Gly Val Lys Gln Ser Gly Leu 
             500                505                510
Gly Arg Glu Gly Ser Lys Tyr Gly Ile Asp Glu Tyr Leu Glu Leu Lys 
         515                520                525
Tyr Val Cys Tyr Gly Gly Leu 
     530                535



<210> 3208
<211> 2006
<212> DNA
<213> Rattus norvegicus
<308> L35271
<400> 3208

gaattctcc  aatctagtt  gtttttttt  ctggtcatt  tttttaatt  tgcgcataa  60
tattttagg  cgcatacgg  aattttgcc  ccgggaccg  ttgtaatag  caaagactg  120
actccaaac  ctgaaagcg  ggctccttg  ggcatttga  tttgaattc  gggttgccc  180
cttttcaat  cactaagcg  ccagttgct  accctgcct  ggtgtaagg  cgatccgcg  240
aactagatc  cagtcctgc  acccccaca  ccctccggt  gtaataaag  ctcctgaac  300
tgtatgttg  tctcccggg  gcagcttgc  gaagatccg  gtccctgtc  ccgtctagt  360
ggagctgtt  tcagggtcc  tactcaatc  gcttgttgt  atgcgtatc  ccgtagatg  420
cagcacgag  cgccgcttc  cgccgcctt  cactgcgct  agccccggc  agatgagcg  480
ggcgctgcc  ctgggcgcc  cggatggcg  cgccgccct  gccagcaag  tgaggagcg  540
cgaccgcag  atggtggag  tactagctg  ccaccccgg  gagctagtc  gcaccgaca  600
ccccaactt  ctctgctcc  tgctgccca  tcactggcg  tgcaacaag  ccctgccca  660
cgctttcaa  gtggtagcg  tgggcgacg  tccggatgg  actctggtc  ccgtcatgg  720
gggcaatga  gaaaactac  cggcggagc  gagaaacgc  accgcggcc  tgaagaacc  780
agtggcgag  ttcaacgac  tcaggtttg  cggtcggag  ggcagaggc  agagcttca  840
tctgaccat  accgtcttt  caaaccccc  acaagttgc  acctaccat  gagccatca  900
aatcacagt  gacggcccc  gagaacccc  aagacatcg  cagaaacta  atgatcaga  960
caagcccgg  agtttgtcc  tttccgagc  gctcagtga  ctggagcag  tgcggcgca  1020
ggccatgag  gtcagcccg  atcacccag  ccccacgcc  aaccctcgg  cctccttga  1080
ccactccac  gcctttaac  ctcagcctc  aagtcagat  caggatgcc  ggcagatcc  1140
gccgtcccc  ccgtggtcc  atgaccagt  ttaccagta  ctggggtcc  tcacctctt  1200
tgtgcaccc  gcgacaccc  tttctcccg  ccgagccag  ggcatgacc  gcctctcag  1260
ggaactttc  agtcgactc  caacagccc  ggacctgac  gccttcggc  acccgcgcc  1320
gttccccac  ctgccgtcc  tctccgacc  gcgcatgca  tacccaggc  ccttcacct  1380
ctcgcctcc  gtcacatcg  gcatcggca  tggcatgtc  gccatgagc  cgacctctc  1440
ctaccacac  tacctgccg  cgccctacc  aggctcctc  caggcgcag  ccgggccct  1500
ccagaccgg  tcgccctcc  accacctgt  ctacggcac  tcggcaggc  cctaccaat  1560
ctccatggt  ggcggcgag  gatcacccc  gcgcatcct  ccgccctgc  ccaacgcgt  1620
caccggagc  gcgctgctc  accccagcc  ccccagcca  agcgacgtg  tggaaaccg  1680
gggcagcca  agcaactcg  ccaccaaca  gccacccgc  cgcctggag  aggctgtct  1740
gcggcccta  tgagcgcct  cgggggact  agcccgccg  ccatgcaca  accccgcca  1800
gagagccct  ggaggccaa  aggagggaa  ctgtgaatg  ttctgattt  gtaatgctg  1860
gaataaaag  aagatttta  acccttgac  tcacttttt  accacgttg  ttattccaa  1920
gagtgtgga  tgttttcgg  tccgggtgg  gaagacgca  cccatcctg  ttggcatct  1980
tttcttttc  gcaccttat  gattgc  2006



<210> 3209
<211> 450
<212> PRT
<213> Rattus norvegicus
<308> Q63046
<400> 3209

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
  1               5                  10                  15
Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
             20                  25                  30
Ala Pro Asp Gly Gly Ala Ala Leu Ala Ser Lys Leu Arg Ser Gly Asp 
         35                  40                  45
Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
     50                  55                  60
Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
 65                  70                  75                  80
Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                 85                  90                  95
Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
             100                105                110
Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
         115                120                125
Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
     130                135                140
Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
 145                150                155                160
Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                 165                170                175
Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu 
             180                185                190
Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala 
         195                200                205
Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala 
     210                215                220
Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met 
 225                230                235                240
Gln Asp Ala Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln 
                 245                250                255
Ser Tyr Gln Tyr Leu Gly Ser Ile Thr Ser Ser Val His Pro Ala Thr 
             260                265                270
Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Ser Leu Ser Ala Glu 
         275                280                285
Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Gly Asp 
     290                295                300
Pro Arg Gln Phe Pro Thr Leu Pro Ser Ile Ser Asp Pro Arg Met His 
 305                310                315                320
Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Pro Val Thr Ser Gly Ile Gly 
                 325                330                335
Ile Gly Met Ser Ala Met Ser Ser Thr Ser Arg Tyr His Thr Tyr Leu 
             340                345                350
Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Ala Gly Pro Phe Gln 
         355                360                365
Thr Gly Ser Pro Ser Tyr His Leu Tyr Tyr Gly Thr Ser Ala Gly Ser 
     370                375                380
Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg Ile Leu 
 385                390                395                400
Pro Pro Cys Thr Asn Ala Ser Thr Gly Ala Ala Leu Leu Asn Pro Ser 
                 405                410                415
Leu Pro Ser Gln Ser Asp Val Val Glu Thr Glu Gly Ser His Ser Asn 
             420                425                430
Ser Pro Thr Asn Met Pro Pro Ala Arg Leu Glu Glu Ala Val Trp Arg 
         435                440                445
Pro Tyr 
     450



<210> 3210
<211> 7265
<212> DNA
<213> Homo sapiens
<308> D43968
<400> 3210

catagagcc  gcgggcgcg  gcgggacgg  cgccccgcg  ccggaccca  ccagggcac  60
acgctgccc  gccctgcgc  gccaggcac  tctttccgg  gctcctagg  acgccagaa  120
gaagtcaac  tctgctgct  ctccttggc  tgcgttgga  cttcctttt  ttgttgttt  180
tttttgttt  tcccctttc  tccttttga  ttaactggc  tcttggctg  atgttttca  240
cttctttcc  ggctgcgaa  ttttcccca  ttgttttcc  tttacaaca  ggggagaaa  300
tgctctgtg  tccgaggcg  gccgtgaag  tgcgtgtgc  tggcagtgt  cgtggcagg  360
tgtgcgtgc  tgtgtaacc  gagccgccc  atctgtttc  atctgcgcc  cggagccct  420
cctcaaggc  cgctccacc  gctgcggtt  cgcggcgct  gtgggtgtt  gtgcctcgg  480
gcagctaac  ggcgggtgc  gggcgacgg  ggaggagta  cgtctcgct  ctgcccgag  540
cagggctga  tcacccagc  gatgtagac  gtggctgcc  tccgaagag  gcgtgtttg  600
atgtgtgtg  ctctgcggc  gctcaactc  caacaaacc  gaggaccag  cacaaactt  660
accaacatc  ccaaacccg  gttcacaga  gtgggagag  tgtagaacc  tgagtgtca  720
cgactgggc  ttcttatga  tgttgtttt  agattagct  aagatctct  aaacgctga  780
ttttctgca  tgagcgttt  gacagaatt  attgagaga  cagagaaca  gacaagtac  840
tctagctca  cactgctcc  actactgaa  ctgattttc  aggctactt  aaaaaatct  900
cagcgtaca  taatggatt  ctgttgtgt  taaattctc  acagattgt  ttgtaaata  960
tttatgaag  agagcatat  tatatattt  tatatacgt  cacatacat  agtagcact  1020
cctttggaa  tctcagctc  tgcttttcg  gactgaagc  agttttgca  gataaaagt  1080
gccttgtta  gggagataa  tgtgttctg  tgggacttt  gacaaaact  acctgcaaa  1140
aactgacag  cattaacta  tggaacttc  aaataatgt  tttgctgat  gttttactc  1200
tcgcataaa  attttagga  gtgtatgag  attttgcct  caggaactt  tctaacagc  1260
aaagacaga  cttaacctc  gcaagcaag  ttcgtggaa  atagtctcc  ctttttaat  1320
cactaagca  tcggttgct  ggagcccat  ctgggtcag  ggccgatcc  cagaaccag  1380
acgttttcc  ctcctggac  gttagtaac  tagtctccc  cctccccta  ccacccccg  1440
cccccccca  cccccgcag  aataaaggc  cctgaacgt  tatgttggt  tcccgggag  1500
tgcttgctg  agatccgcg  ccctgtcgc  gtctggtag  agctgtttg  agggtccta  1560
ctcaatcgg  ttgttgtga  gcgtatccc  gtagatgcc  gcacgagcc  ccgcttcac  1620
ccgccttcc  ccgcgctga  cccaggcaa  atgagcgag  cgttgccgc  gggcgcccc  1680
gacgccggc  ctgccctgg  cggcaagct  aggagcggc  accgcagca  ggtggaggt  1740
ctggccgac  acccgggcg  gctggtgcg  accgacagc  ccaacttcc  ctgctccgt  1800
ctgcctacg  actggcgct  caacaagac  ctgcccatc  ctttcaagg  ggtggccct  1860
ggggatgtt  cagatggca  tctggtcac  gtgatggct  gcaatgatg  aaactactc  1920
gctgagctg  gaaatgcta  cgcagccat  aagaaccag  ttgcaagat  taatgacct  1980
aggtttgtc  gtcgaagtg  aagagggaa  agcttcact  tgaccatca  tgtcttcac  2040
aacccaccg  aagtcgcca  ctaccacag  gccatcaaa  tcacagtgg  tgggccccg  2100
gaacctcga  gacatcggc  gaaactaga  gatcagacc  agcccggga  cttgtcctt  2160
tccgagcgg  tcagtgaac  ggagcagct  cggcgcaca  ccatgaggg  cagcccaca  2220
cacccagcc  ccacgccca  ccctcgtgc  tccctgaac  actccactg  ctttaaccc  2280
cagcctcag  gtcagatgc  ggatacaag  cagatccaa  catccccac  gtggtccta  2340
gatcagtcc  accaatacc  gggatccat  gcctctcct  ctgtgcacc  agcaacgcc  2400
atttcacct  gacgtgcca  cggcatgac  accctctct  cagaacttt  cagtcgact  2460
tcaacggca  ccgacctga  agcgttcag  gacccgcgc  agttccccg  gctgccctc  2520
atctccgac  cccgcatgc  ctatccagg  gccttcacc  actccccga  gccggtcac  2580
tcgggcatc  gcatcggca  gtcggccat  ggctcggcc  cgcgctacc  cacctacct  2640
ccgccgccc  accccggct  gtcgcaagc  cagggaggc  cgttccaag  cagctcgcc  2700
tcctaccac  tgtactacg  cgcctcggc  ggctcctac  agttctcca  ggtgggcgg  2760
gagcgctcg  cgccgcgca  cctgccgcc  tgcaccaac  cctccaccg  ctccgcgct  2820
ctcaacccc  gcctcccga  ccagagcga  gtggtggag  ccgagggca  ccacagcaa  2880
tcccccacc  acatggcgc  ctccgcgcg  ctggaggag  ccgtgtgga  gccctactg  2940
ggcgccagg  ctggcccgg  tgggccacg  gggccgccg  cttcgcctc  gggcgcgcg  3000
gcctcctgt  cgcgacaag  ccgccggga  cccgggccc  gggcccggc  accgtcctg  3060
ggccgaggg  gcccgacgg  caggatctc  ctgtaggtc  ggcccgcgc  gcctcctgc  3120
cccagaagc  cacgccgcc  ccgtctgct  gcgccccgg  cctcgcgga  gtgtccgag  3180
cgacgcacc  cgagggtgt  cgccggccc  agcacccag  ggacgcgct  gaaagcaaa  3240
aggaagatt  ccggaggga  actgtgaat  cttctgatt  agcaatgct  tgaataaaa  3300
gaaagattt  atacccttg  cttaacttt  taaccaagt  gtttattcc  aagagtgtg  3360
aattttggt  ggggtgggg  gagaggagg  atgcaactc  ccctgtttg  catctaatt  3420
ttattttta  tttttccgc  ccttatcaa  tgcaaaatg  gtatttgca  ttgggtggt  3480
tttattttt  tatacgttt  tataaatat  tataaattg  gcttgcttc  ttcttgctt  3540
gaccatgga  agaaatatg  ttccctttt  tttaagttt  atttaactt  tcttttgga  3600
ttttgggta  ttgtttttt  ttgttttgt  ttgtttttt  gagaaacag  tacagcttt  3660
ggtcatttt  aactactgt  ttcccacaa  gaatcccca  atatttatg  atcttgatg  3720
tcagacatt  atgtgttga  aatttttta  ttatttaaa  gtacttata  taagaaaaa  3780
atcaagtac  acattttct  ttgttcttg  tagtagcca  agttaaatg  atcacattg  3840
agaaggcta  aaaaaaaga  tgagtaatg  gatcgcttg  ttatccaga  gtattgttt  3900
cattaaact  cctttcatg  taatcaaac  agtgagtag  tcacgcagc  acgttttta  3960
taggatttt  agacactga  ggtcactcc  aggatcaga  gtatggaat  ttctgccag  4020
ctcaacaag  gtctcatat  taacttcct  cttaaaaca  agaaggtca  tctagttcc  4080
gagggttga  gcgggtgcc  ataattaca  ctttggaga  gatttgatt  ctgcccagg  4140
atttgctca  cccaaggtc  tctgataat  tcacagatg  tgtgtaaca  aacacagcc  4200
aagtaaact  tgtagggga  ccacattta  ataggaacc  aatcaatga  tttaggggt  4260
acgattata  caatttaag  gccaccaga  gcaggcctc  aggagtcaa  ttgcctctg  4320
gtgcctcag  ggagacaag  gggaaaaca  ggtcccacc  gtgcgagac  ccctgtcct  4380
tgctgctca  tcaacaaca  ctttgtgtt  ctttcacca  gctgagacc  taccctatg  4440
ggtatatgg  cttttacct  tgcaccagt  tgacaggaa  gattcatgt  actactgtc  4500
gtggctaca  ttcaaaggt  tccaatgtc  ctgtaaatt  tatggcact  tttttattg  4560
aggatttgg  cagaatgca  ttgttgtac  actcataaa  actaactgc  gattttgac  4620
catgtgtgc  ccaaatgat  tggtggtta  ttaacgtac  tcttaaaat  cgttgaaac  4680
atttcaggt  aactctgaa  agtatttga  agcaggact  cagaacagt  tttgatttt  4740
attttataa  tttaagcat  caaattagg  aaatctttg  ctgcaggca  caaaaacag  4800
tggacttat  taaaacaac  tgtttttga  ttttcttat  tatatattg  ttatttgtt  4860
tacacacat  cagtagcac  ttggtaaga  ttaaagagt  aagcagctt  tgttgtcag  4920
tcgttctta  ctagagaag  gctatagca  atctcggac  aactcagaa  atattcact  4980
tcatttttg  caggattcc  tccacaact  agtttcata  attattccg  attacattt  5040
tgcagctaa  ttaccataa  atgtcagca  atgtaaaaa  ttaatttct  aaaagcacc  5100
ttagcccat  tcccccaaa  taaacgtaa  tgttttttt  cagcacatg  taccatgtc  5160
gacctgcaa  aatgctgga  aaaaatgaa  gaaaaaatt  tgtttttca  tttaattct  5220
ttaactgaa  atattccaa  tcaaaacca  cctcatgct  tgattagat  atcttttac  5280
ttgaacctt  actctcaaa  ccatgtgtg  agggggctt  tcactattg  aggctcact  5340
gattggtca  ttagagttt  acagactct  accagcata  atagtattt  attgtttca  5400
aaaaaatca  actgtagtt  ttttggcga  aggtctcac  caacacatt  ttgtatgtg  5460
gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  aaaattgca  tcattgact  caggtagat  5520
aaggtatct  tttattcat  gccctcagg  aagttaagg  atcaatgag  cccttaagc  5580
aatcatgta  taactgcat  tgtctggtc  aggagaagt  ttgaataag  catttctac  5640
gcttactca  gtccctatt  atgatttca  catggatac  tatttcagt  ctttctttt  5700
ctcactatc  gaaaataca  ttccctccc  ctcttcccc  caatatctc  ctttttttc  5760
ctcttcctc  atcttccaa  ccccacttt  tccctcctc  ttttcctgt  ttctcttaa  5820
cagatagca  ataccccca  ccagtacca  atttcagaa  acaagaagg  ccagttctt  5880
ccccttcac  taaaggaac  tggtttgtc  gcctttctc  tgtttatgg  tttcttcca  5940
cagaacaga  acattgcca  ccatattgg  tctgcttgc  gtccaaacc  gcaaacttc  6000
tgggcaaat  acaatcagt  agtaaatag  cagcctttc  gctgccttg  gtttctgtg  6060
agataaaca  aaatgctct  attagaaag  aaatgaatg  ttccactca  atgtcctgc  6120
atttaggat  gcagatttc  gccttgaaa  acctgtttc  ttgggacat  ccgtcctga  6180
gatttttat  tttgttggt  tttattttt  gggggaatg  catgtttgg  tcttttata  6240
atgaaaatt  gtttgacaa  aatctcaca  aacatattt  acatctgaa  aaaatgcct  6300
tttgtttac  gtagcgtat  catttgttt  gggattttt  tgtgtttgt  gggaatttt  6360
tttttagcc  ggtcagtat  gatgaggct  atcatttgg  tcttttttt  cttccagaa  6420
agttgcatc  acaaagtta  ttgtattta  gtatgtaaa  agattttaa  cttcattat  6480
aaatattgt  aatgcctat  acttttttt  aattttttt  tgtgtgttt  taaggactt  6540
ttcttaggt  tgctaaata  tgtagggaa  aaatgcttc  ttctaactt  gtttatttt  6600
gactttaaa  tgagctact  cttattcac  tttgtaaac  gctaatagc  tggttccaa  6660
tttttttaa  ttcactttt  ttgttctag  ggaaatgaa  gtgcaaaaa  agaaaaaga  6720
ctgttggtt  tttgtgtta  tctggatgt  taaaaatca  tggaaaaaa  taaactttc  6780
aattgaaat  acggtataa  acatctact  aaaaagcaa  gggaaatgt  gtcctattt  6840
agccagccc  cacctaggg  ctatttgtg  ggcagttat  gggtttggt  acaaaacat  6900
ctgaaaatt  gtgcgtggg  ttctttctc  ctggtacaa  cgtatggaa  gcttcttaa  6960
ggggaactg  caagctggt  tcttcagcc  gatgacatg  gagaatatc  cagaaccct  7020
tctccaagg  gtttctaga  agcacagga  agcaggcac  gcactgtcc  cagtccacg  7080
tacacagtc  ggtgggccg  ctcccctct  ctgggagca  tcgtcgtgc  cagcctgag  7140
agggcagct  gactgctgc  gttcaggag  caccagagc  ttcctctct  tgtaccaca  7200
tttcttctg  aaatccagt  ttacaatca  tgtgaatgg  aaataaaca  tttgacaag  7260
acata  7265



<210> 3211
<211> 453
<212> PRT
<213> Homo sapiens
<308> O60472
<400> 3211

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
  1               5                  10                  15
Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
             20                  25                  30
Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
         35                  40                  45
Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
     50                  55                  60
Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
 65                  70                  75                  80
Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                 85                  90                  95
Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
             100                105                110
Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
         115                120                125
Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
     130                135                140
Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
 145                150                155                160
Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                 165                170                175
Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu 
             180                185                190
Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala 
         195                200                205
Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala 
     210                215                220
Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met 
 225                230                235                240
Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln 
                 245                250                255
Ser Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala 
             260                265                270
Thr Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala 
         275                280                285
Glu Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser 
     290                295                300
Asp Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met 
 305                310                315                320
His Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly 
                 325                330                335
Ile Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr 
             340                345                350
Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro 
         355                360                365
Phe Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala 
     370                375                380
Gly Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg 
 385                390                395                400
Ile Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Phe Ala Leu Leu Asn 
                 405                410                415
Pro Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu Gly Ser His 
             420                425                430
Ser Asn Ser Pro Thr Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala 
         435                440                445
Val Trp Arg Pro Tyr 
     450



<210> 3212
<211> 1298
<212> DNA
<213> Rattus norvegicus
<308> L35571
<400> 3212

gaattccgc  gaggctggg  gcgcgaccc  ggtccttct  cccccggcc  tacgctttg  60
tcacgtctc  ctctgcatg  tggatatta  ttttcatta  ccttttctg  gtgctatgg  120
ggatcattc  aagaagaag  ccgggacgg  catgtgcgt  ggctgcggg  gtcagatcc  180
cgaccagtt  atccttcgg  tgtcgcccg  cctcgagtg  cacgccgcc  gcctcaagt  240
cgctgagtg  agccagtat  tggatgaga  gtgcacgtg  ttcgtgaga  acgggaaaa  300
gtactgcaa  cgggactac  tcaggctgt  cggcatcaa  tgtgcccag  gtcaggtgg  360
cttcagcag  agtgacctg  tgatgcggg  gcgggacag  gtgtaccac  tcgagtgct  420
ccgctgctc  gtgtgcagc  gccagctgc  ccctggaga  gagttctcg  tgagggagc  480
cgagctgct  tgccgagcc  accacggcc  cctgctgga  cgcgctgcg  ccggcagcc  540
gcgcagccc  ggcccgctc  ccggcaccc  accaggcct  catctgcca  acgccgggt  600
cggacaaca  gtctcactg  gcacgcacg  gcacaagca  gcggagaag  caacccggg  660
gcggactgt  ctcaacgag  agcaactgc  caccctgcg  acatgctac  ccgccaacc  720
gcggcccga  gcgctcatg  aggagcagc  ggtagagat  accggcttg  gcccgcggg  780
catccgcgt  tggtttcag  acaagcgtt  caaggacaa  aagaagtcc  ttctcatga  840
gcagctaca  cagcagcaa  acagcgaca  ggcgagtct  cagggacta  ctgggacgc  900
cctggtggc  ggcagccca  ccgcccatg  gaacgccgt  cagggcagc  cagtcgagg  960
gcagacgta  cagccgccc  ggaaagctc  cagcgagtt  gcactccag  gcgacctgg  1020
tcaacccgc  tttcaacag  tggtctcct  ctccgagtc  ggctcccta  gcaactcct  1080
tggtagcga  gtgacctct  tgtcttcgc  gctcccgga  acccccaac  gtatggtac  1140
tagtccggt  gagacgtga  acaggaccc  tccctgcca  cccgcggac  tcgcatgcc  1200
ccctgcatg  gactcaccc  tgctcaggc  attccagct  tgaaaaatc  ccggccctt  1260
taattattg  tgttattta  aggcgagcg  gcagagga  1298



<210> 3213
<211> 360
<212> PRT
<213> Rattus norvegicus
<308> P50480
<400> 3213

Met Val Asp Ile Ile Phe His Tyr Pro Phe Leu Gly Ala Met Gly Asp 
  1               5                  10                  15
His Ser Lys Lys Lys Pro Gly Thr Ala Met Cys Val Gly Cys Gly Ser 
             20                  25                  30
Gln Ile His Asp Gln Phe Ile Leu Arg Val Ser Pro Asp Leu Glu Trp 
         35                  40                  45
His Ala Ala Cys Leu Lys Cys Ala Glu Cys Ser Gln Tyr Leu Asp Glu 
     50                  55                  60
Thr Cys Thr Cys Phe Val Arg Asp Gly Lys Thr Tyr Cys Lys Arg Asp 
 65                  70                  75                  80
Tyr Val Arg Leu Phe Gly Ile Lys Cys Ala Gln Cys Gln Val Gly Phe 
                 85                  90                  95
Ser Ser Ser Asp Leu Val Met Arg Ala Arg Asp Ser Val Tyr His Ile 
             100                105                110
Glu Cys Phe Arg Cys Ser Val Cys Ser Arg Gln Leu Leu Pro Gly Asp 
         115                120                125
Glu Phe Ser Leu Arg Glu His Glu Leu Leu Cys Arg Ala Asp His Gly 
     130                135                140
Leu Leu Leu Glu Arg Ala Ala Ala Gly Ser Pro Arg Ser Pro Gly Pro 
 145                150                155                160
Leu Pro Gly Thr Pro Pro Gly Leu His Leu Pro Asp Ala Gly Ser Gly 
                 165                170                175
Gln Gln Val Ser Leu Arg Thr His Val His Lys Gln Ala Glu Lys Thr 
             180                185                190
Thr Arg Val Arg Thr Val Leu Asn Glu Lys Gln Leu His Thr Leu Arg 
         195                200                205
Thr Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala Leu Met Lys Glu Gln 
     210                215                220
Leu Val Glu Met Thr Gly Leu Ser Pro Arg Val Ile Arg Val Trp Phe 
 225                230                235                240
Gln Asn Lys Arg Cys Lys Asp Lys Lys Lys Ser Ile Leu Met Lys Gln 
                 245                250                255
Leu Gln Gln Gln Gln His Ser Asp Lys Ala Ser Leu Gln Gly Leu Thr 
             260                265                270
Gly Thr Leu Leu Val Ala Gly Ser Pro Ser Ala His Glu Asn Ala Val 
         275                280                285
Gln Gly Ser Ala Val Glu Val Gln Thr Tyr Gln Pro Pro Trp Lys Ala 
     290                295                300
Leu Ser Glu Phe Ala Leu Gln Ser Asp Leu Asp Gln Pro Ala Phe Gln 
 305                310                315                320
Gln Leu Val Ser Phe Ser Glu Ser Gly Ser Leu Gly Asn Ser Ser Gly 
                 325                330                335
Ser Asp Val Thr Ser Leu Ser Ser Gln Leu Pro Asp Thr Pro Asn Ser 
             340                345                350
Met Val Pro Ser Pro Val Glu Thr 
         355                360



<210> 3214
<211> 448
<212> DNA
<213> Homo sapiens
<308> AI972048
<400> 3214

caccgccgc  ccttgggcc  gcaggctgt  cggcatcaa  tgcgccaag  gccaggtgg  60
cttcagcag  agcgacctg  tgatgaggg  gcgggacag  gtgtaccac  tcgagtgct  120
ccgctgctc  gtgtgcagc  gccagctgc  gcctgggga  gagttctcg  tgcgggagc  180
cgagctgct  tgccgcgcc  accacggcc  cctgctcga  cgcgccgcg  ccggcagcc  240
gcgcagccc  ggcccgctt  ccggcgccc  cggcctgca  ctgcccggt  agcgcgccg  300
ggcctgtgc  ggggtgagc  gggtgtatg  gcgtgcgtg  gtgtagggg  acgcttgtg  360
ccctaacga  aagttgtca  ttgtgtgtg  ttccgtctg  cgggatagt  tttttctgt  420
tcagtgcgg  actgtggtg  tgggaaca  448



<210> 3215
<211> 359
<212> PRT
<213> Homo sapiens
<308> XP_047951
<400> 3215

Met Val Asp Ile Ile Phe His Tyr Pro Phe Leu Gly Ala Met Gly Asp 
  1               5                  10                  15
His Ser Lys Lys Lys Pro Gly Thr Ala Met Cys Val Gly Cys Gly Ser 
             20                  25                  30
Gln Ile His Asp Gln Phe Ile Leu Arg Val Ser Pro Asp Leu Glu Trp 
         35                  40                  45
His Ala Ala Cys Leu Lys Cys Ala Glu Cys Ser Gln Tyr Leu Asp Glu 
     50                  55                  60
Thr Cys Thr Cys Phe Val Arg Asp Gly Lys Thr Tyr Cys Lys Arg Asp 
 65                  70                  75                  80
Tyr Val Arg Leu Phe Gly Ile Lys Cys Ala Lys Cys Gln Val Gly Phe 
                 85                  90                  95
Ser Ser Ser Asp Leu Val Met Arg Ala Arg Asp Ser Val Tyr His Ile 
             100                105                110
Glu Cys Phe Arg Cys Ser Val Cys Ser Arg Gln Leu Leu Pro Gly Asp 
         115                120                125
Glu Phe Ser Leu Arg Glu His Glu Leu Leu Cys Arg Ala Asp His Gly 
     130                135                140
Leu Leu Leu Glu Arg Ala Ala Ala Gly Ser Pro Arg Ser Pro Gly Pro 
 145                150                155                160
Leu Pro Gly Ala Arg Gly Leu His Leu Pro Asp Ala Gly Ser Gly Arg 
                 165                170                175
Gln Pro Ala Leu Arg Pro His Val His Lys Gln Thr Glu Lys Thr Thr 
             180                185                190
Arg Val Arg Thr Val Leu Asn Glu Lys Gln Leu His Thr Leu Arg Thr 
         195                200                205
Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala Leu Met Lys Glu Gln Leu 
     210                215                220
Val Glu Met Thr Gly Leu Ser Pro Arg Val Ile Arg Val Trp Phe Gln 
 225                230                235                240
Asn Lys Arg Cys Lys Asp Lys Lys Lys Ser Ile Leu Met Lys Gln Leu 
                 245                250                255
Gln Gln Gln Gln His Ser Asp Lys Thr Ser Leu Gln Gly Leu Thr Gly 
             260                265                270
Thr Pro Leu Val Ala Gly Ser Pro Ile Arg His Glu Asn Ala Val Gln 
         275                280                285
Gly Ser Ala Val Glu Val Gln Thr Tyr Gln Pro Pro Trp Lys Ala Leu 
     290                295                300
Ser Glu Phe Ala Leu Gln Ser Asp Leu Asp Gln Pro Ala Phe Gln Gln 
 305                310                315                320
Leu Val Ser Phe Ser Glu Ser Gly Ser Leu Gly Asn Ser Ser Gly Ser 
                 325                330                335
Asp Val Thr Ser Leu Ser Ser Gln Leu Pro Asp Thr Pro Asn Ser Met 
             340                345                350
Val Pro Ser Pro Val Glu Thr 
         355



<210> 3216
<211> 1298
<212> DNA
<213> Rattus norvegicus
<308> L35571
<400> 3216

gaattccgc  gaggctggg  gcgcgaccc  ggtccttct  cccccggcc  tacgctttg  60
tcacgtctc  ctctgcatg  tggatatta  ttttcatta  ccttttctg  gtgctatgg  120
ggatcattc  aagaagaag  ccgggacgg  catgtgcgt  ggctgcggg  gtcagatcc  180
cgaccagtt  atccttcgg  tgtcgcccg  cctcgagtg  cacgccgcc  gcctcaagt  240
cgctgagtg  agccagtat  tggatgaga  gtgcacgtg  ttcgtgaga  acgggaaaa  300
gtactgcaa  cgggactac  tcaggctgt  cggcatcaa  tgtgcccag  gtcaggtgg  360
cttcagcag  agtgacctg  tgatgcggg  gcgggacag  gtgtaccac  tcgagtgct  420
ccgctgctc  gtgtgcagc  gccagctgc  ccctggaga  gagttctcg  tgagggagc  480
cgagctgct  tgccgagcc  accacggcc  cctgctgga  cgcgctgcg  ccggcagcc  540
gcgcagccc  ggcccgctc  ccggcaccc  accaggcct  catctgcca  acgccgggt  600
cggacaaca  gtctcactg  gcacgcacg  gcacaagca  gcggagaag  caacccggg  660
gcggactgt  ctcaacgag  agcaactgc  caccctgcg  acatgctac  ccgccaacc  720
gcggcccga  gcgctcatg  aggagcagc  ggtagagat  accggcttg  gcccgcggg  780
catccgcgt  tggtttcag  acaagcgtt  caaggacaa  aagaagtcc  ttctcatga  840
gcagctaca  cagcagcaa  acagcgaca  ggcgagtct  cagggacta  ctgggacgc  900
cctggtggc  ggcagccca  ccgcccatg  gaacgccgt  cagggcagc  cagtcgagg  960
gcagacgta  cagccgccc  ggaaagctc  cagcgagtt  gcactccag  gcgacctgg  1020
tcaacccgc  tttcaacag  tggtctcct  ctccgagtc  ggctcccta  gcaactcct  1080
tggtagcga  gtgacctct  tgtcttcgc  gctcccgga  acccccaac  gtatggtac  1140
tagtccggt  gagacgtga  acaggaccc  tccctgcca  cccgcggac  tcgcatgcc  1200
ccctgcatg  gactcaccc  tgctcaggc  attccagct  tgaaaaatc  ccggccctt  1260
taattattg  tgttattta  aggcgagcg  gcagagga  1298



<210> 3217
<211> 360
<212> PRT
<213> Rattus norvegicus
<308> P50480
<400> 3217

Met Val Asp Ile Ile Phe His Tyr Pro Phe Leu Gly Ala Met Gly Asp 
  1               5                  10                  15
His Ser Lys Lys Lys Pro Gly Thr Ala Met Cys Val Gly Cys Gly Ser 
             20                  25                  30
Gln Ile His Asp Gln Phe Ile Leu Arg Val Ser Pro Asp Leu Glu Trp 
         35                  40                  45
His Ala Ala Cys Leu Lys Cys Ala Glu Cys Ser Gln Tyr Leu Asp Glu 
     50                  55                  60
Thr Cys Thr Cys Phe Val Arg Asp Gly Lys Thr Tyr Cys Lys Arg Asp 
 65                  70                  75                  80
Tyr Val Arg Leu Phe Gly Ile Lys Cys Ala Gln Cys Gln Val Gly Phe 
                 85                  90                  95
Ser Ser Ser Asp Leu Val Met Arg Ala Arg Asp Ser Val Tyr His Ile 
             100                105                110
Glu Cys Phe Arg Cys Ser Val Cys Ser Arg Gln Leu Leu Pro Gly Asp 
         115                120                125
Glu Phe Ser Leu Arg Glu His Glu Leu Leu Cys Arg Ala Asp His Gly 
     130                135                140
Leu Leu Leu Glu Arg Ala Ala Ala Gly Ser Pro Arg Ser Pro Gly Pro 
 145                150                155                160
Leu Pro Gly Thr Pro Pro Gly Leu His Leu Pro Asp Ala Gly Ser Gly 
                 165                170                175
Gln Gln Val Ser Leu Arg Thr His Val His Lys Gln Ala Glu Lys Thr 
             180                185                190
Thr Arg Val Arg Thr Val Leu Asn Glu Lys Gln Leu His Thr Leu Arg 
         195                200                205
Thr Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala Leu Met Lys Glu Gln 
     210                215                220
Leu Val Glu Met Thr Gly Leu Ser Pro Arg Val Ile Arg Val Trp Phe 
 225                230                235                240
Gln Asn Lys Arg Cys Lys Asp Lys Lys Lys Ser Ile Leu Met Lys Gln 
                 245                250                255
Leu Gln Gln Gln Gln His Ser Asp Lys Ala Ser Leu Gln Gly Leu Thr 
             260                265                270
Gly Thr Leu Leu Val Ala Gly Ser Pro Ser Ala His Glu Asn Ala Val 
         275                280                285
Gln Gly Ser Ala Val Glu Val Gln Thr Tyr Gln Pro Pro Trp Lys Ala 
     290                295                300
Leu Ser Glu Phe Ala Leu Gln Ser Asp Leu Asp Gln Pro Ala Phe Gln 
 305                310                315                320
Gln Leu Val Ser Phe Ser Glu Ser Gly Ser Leu Gly Asn Ser Ser Gly 
                 325                330                335
Ser Asp Val Thr Ser Leu Ser Ser Gln Leu Pro Asp Thr Pro Asn Ser 
             340                345                350
Met Val Pro Ser Pro Val Glu Thr 
         355                360



<210> 3218
<211> 448
<212> DNA
<213> Homo sapiens
<308> AI972048
<400> 3218

caccgccgc  ccttgggcc  gcaggctgt  cggcatcaa  tgcgccaag  gccaggtgg  60
cttcagcag  agcgacctg  tgatgaggg  gcgggacag  gtgtaccac  tcgagtgct  120
ccgctgctc  gtgtgcagc  gccagctgc  gcctgggga  gagttctcg  tgcgggagc  180
cgagctgct  tgccgcgcc  accacggcc  cctgctcga  cgcgccgcg  ccggcagcc  240
gcgcagccc  ggcccgctt  ccggcgccc  cggcctgca  ctgcccggt  agcgcgccg  300
ggcctgtgc  ggggtgagc  gggtgtatg  gcgtgcgtg  gtgtagggg  acgcttgtg  360
ccctaacga  aagttgtca  ttgtgtgtg  ttccgtctg  cgggatagt  tttttctgt  420
tcagtgcgg  actgtggtg  tgggaaca  448



<210> 3219
<211> 560
<212> DNA
<213> Rattus norvegicus
<308> L35921
<400> 3219

ggaggtgga  gaggaggag  ggggggggg  gaagagggg  aggagaagg  ggattcatt  60
ttgcaggga  tggactcag  gaaacagac  cagggcatg  agacaggtg  tgcctagga  120
gaggaggcg  tcctgaggg  ctgcacccc  ggggagggg  cggggctgg  aatgggatc  180
gcagaaccg  cagccatcc  agccctgag  tgcaacagc  atgtccaac  acatggcca  240
gatcgctga  gcccgcaag  cggtggagc  actgaagct  gaggtgaac  tcgatcgca  300
gaaggtgtc  caggcggca  cggagctat  ggctttctg  gaaacgcac  ctaaggatg  360
cccactggt  actcctgtc  ctgccgccg  gaatccctt  cgcgacaaa  gactctttt  420
caccctgct  tgagccccc  agatagttt  atcctcccg  gcagaaata  gaatccaat  480
aacttggtg  cttggtggt  cctgccatt  aggggaaaa  gaggcacgg  gcaaaaacg  540
gggggccac  tttgtgggga  560



<210> 3220
<211> 70
<212> PRT
<213> Rattus norvegicus
<308> P43426
<400> 3220

Met Ser Asn Asn Met Ala Lys Ile Ala Glu Ala Arg Lys Thr Val Glu 
  1               5                  10                  15
Gln Leu Lys Leu Glu Val Asn Ile Asp Arg Met Lys Val Ser Gln Ala 
             20                  25                  30
Ala Ala Glu Leu Leu Ala Phe Cys Glu Thr His Ala Lys Asp Asp Pro 
         35                  40                  45
Leu Val Thr Pro Val Pro Ala Ala Glu Asn Pro Phe Arg Asp Lys Arg 
     50                  55                  60
Leu Phe Cys Thr Leu Leu 
 65                  70



<210> 3221
<211> 213
<212> DNA
<213> Homo sapiens
<308> NM_033258
<400> 3221

atgtccaac  acatggcca  gattgccga  gcccgcaag  cggtggaac  gctgaagct  60
gaggtgaac  tcgaccgca  gaaggtgtc  caggcagca  cggaactcc  ggctttctg  120
gagacgcat  ccaaagatg  cccgctggt  acgccagta  ccgccgcgg  gaacccctt  180
cgcgacaag  gcctctttt  tgttctgct  tga  213



<210> 3222
<211> 70
<212> PRT
<213> Homo sapiens
<308> NP_150283
<400> 3222

Met Ser Asn Asn Met Ala Lys Ile Ala Glu Ala Arg Lys Thr Val Glu 
  1               5                  10                  15
Gln Leu Lys Leu Glu Val Asn Ile Asp Arg Met Lys Val Ser Gln Ala 
             20                  25                  30
Ala Ala Glu Leu Leu Ala Phe Cys Glu Thr His Ala Lys Asp Asp Pro 
         35                  40                  45
Leu Val Thr Pro Val Pro Ala Ala Glu Asn Pro Phe Arg Asp Lys Arg 
     50                  55                  60
Leu Phe Cys Val Leu Leu 
 65                  70



<210> 3223
<211> 3917
<212> DNA
<213> Rattus norvegicus
<308> L36088
<400> 3223

gtcgcccgg  ccaaagaca  tccacatgt  ggttcctga  ctgaggatc  agcctgcac  60
ccctgctat  cggaaagtc  gtgttcccg  ctgaccgag  ctcctcttg  tacaggctc  120
gcacttgtc  gctggctct  gggctgtga  aagggaaga  tggtgcagc  tctgaagca  180
tagttggtt  gggtcctga  ttgaggact  tcatctccc  gagtcacgt  tctcaccag  240
gtccgtcaa  cttctggaa  agtgaaacc  caggcaact  ttcgaggtc  aacactcag  300
gtctaactg  ggttgatgg  gcatagggt  cccacacag  cttcacgcg  tcgtctcgg  360
tccaggttg  ccctaccct  agctcccgg  tgtgcgtga  tccagcgtg  tctatccag  420
cttcaatct  aacaatctt  attcctgta  ccggcctgg  gggaccctg  atggcagga  480
gaggagacc  tggtcacca  agctatcac  gtttgcaga  ctcgtcaca  ctcttctcc  540
cctatctcc  aggaccatg  ccctgggga  tttccgaag  gtctttttg  tgctgtcgg  600
ggccttggg  ctaactaag  gagacttgg  gaagccctc  aggggtcag  tggtaaact  660
cacttgtga  aacccacac  gcaagaggc  aatctgcca  ggggcatgg  gcacagtgg  720
gctagttcg  gagcagggc  ggcaccccc  ggtctatcg  ggctgcggg  gcctgaacc  780
ggagctctg  ctgggacgt  ccacggagt  tgtgaacca  cactgctgc  atagatcct  840
ctgcaacca  aatgtgtcc  tgatgctgg  ggccaccca  actccttcg  aggagccag  900
agtagatgc  catctgcct  tgatcctgg  tcccgtgct  gccttgctg  tcctggtgg  960
cctgggcac  ctgggcttg  ggcgtgtcc  gagaaggca  gagaagcag  ggggtctgc  1020
cagtgacct  ggcgagtcc  gtctcatcc  gaaggcatc  gaacaggga  acagcatgt  1080
gggggactt  ctggtcagc  actgtacca  aggcagcgg  tcagggcta  ccttcttgg  1140
gcagaggac  gtagcgcga  aggttgcac  ggtggagtg  gtgggaaag  gccgatatg  1200
cgaggtgtg  cgcggttcg  ggcatggcg  gagtgtggc  gtcaagatt  tctcctcac  1260
agatgagca  tcctggttc  gggagacag  gatctacaa  acagttctg  ttagacacg  1320
caacatcct  ggcttcatc  cctccgaca  gacctcgcg  aactccagc  cgcagctgt  1380
gcttatcac  cactaccac  agcatggct  cctctatga  tttctgcag  ggcagacgc  1440
ggagcccca  ttggccctg  ggctggctg  gtccgcggc  tgcggcctg  cgcacctgc  1500
tgtagagat  tttggcact  aaggcaaac  agccatcgc  catcgtgac  tcaagagcc  1560
caacgtgct  gtcaagagc  acttgcagt  ttgcattgc  gacctggga  tggctgtga  1620
gcactcgca  agcagcgat  acctggaca  tggtaacaa  ccccgagtg  gtaccaaga  1680
atacatggc  cccgaggtg  tggatgagc  gatccgcac  gactgtttt  agtcgtaca  1740
gtggacaga  atctgggcc  tcggcttag  gctatggga  attgcccgg  ggaccatca  1800
caatggcat  gtggaggac  acaggccac  cttctatga  atggtaccc  atgacccca  1860
ttttgagga  atgaaaaag  tggtgtgtg  tgaccagca  acccccacc  tccctaacc  1920
actggcagc  gatccggtc  tctccgggc  ggcccagat  atgcgagag  gctggtacc  1980
caacccctc  gctcgcctc  ccgcactgc  cataaagaa  acattacag  agctcagcc  2040
gaatccaga  aaacccaaa  tgattcact  gcccagcat  accagactt  ctctgccta  2100
agtatgtgc  gggccagaa  acatagccc  tctgggtag  ggtagctcg  gtgtgcagg  2160
tgccctgcg  gtgcctgct  agcttggcc  ccagcccat  cagccaaaa  tacagctgg  2220
ctgaaattc  atccgcctc  gtctggcct  ctcaaagtg  ccggctctc  gacgcctgg  2280
tggattccc  gtccccaag  ccagcagag  acaccccct  ccactccca  ggcagggtg  2340
ccaagccag  gaatcccgg  cccggatcc  gggctttca  tccccaccc  tggtcaacc  2400
tgctgcccc  tcagagctg  caggatcgg  cagggccct  tccagattc  gcagacatt  2460
cacctgctg  ggctcagcc  gagagatac  cagcagcct  agtgtctct  tgtgggtgt  2520
tattgctcc  atgatgcct  tccgttgtc  tgactagac  ccctggcta  cgaatgcta  2580
tctcttggg  gaggtggta  ctgaccctt  cacccaccg  ccccttacc  cctcagctg  2640
ctcattaag  catcaaaac  caagggtcc  ctgaggaga  ggtcaagca  ggtagaagg  2700
acccagcat  gctccctct  ataggagag  acttcactg  cttaggatc  tttgtccca  2760
tgtcctttg  ggtgtctca  aacctgatt  tccttgaag  tcaggctgt  tgaaagcta  2820
gtcttgtct  ctacacccc  ttcctatca  ttgagtcaa  ctgtggttt  taaatagcc  2880
ccacagtcc  ggatggccc  acgtgcccc  gggctaatc  ccaggcccc  gttcttgcc  2940
tgagctttg  aagtggcca  cctgggacc  gggcagcac  ggaatttct  actccctct  3000
tggcttggt  ttctgccca  ggctccggg  gggggtggt  gtggtgact  cctttgggg  3060
cttccaaga  taaaaggaa  ttcggcccc  gtcaagaag  ctccagcaa  cagggttct  3120
cacctcctg  ctgtgactc  ctggccaaa  ccacactct  ggccaggtc  cagaaagtg  3180
accttggga  aacttggcc  acagaaaca  caagagtcc  agcatttag  aatgtgaag  3240
gtacacccc  tcccgaagc  tgagttgat  gactggaga  aagcgggct  taggcaagg  3300
ttatggagg  caaagtagg  ctcgggcaa  agacaagat  agcatccat  ttgggaaga  3360
ctggcctag  aacccttgg  ctttgaagg  tgaaacaac  gagacagtt  atcctgctc  3420
gcacacgtg  cgacccgcc  gacgcgacc  accgcttga  ttcctccgg  gtgtgctcc  3480
agctctcca  aatgtcact  aagactacc  ttcagcagt  tgcaaggac  aaggagaac  3540
aggaagtga  acgagatgg  aaacagaaa  taaacggga  tttttcaga  cagtggggc  3600
aagtctgaa  gttctctgg  cactggagc  agggaatcg  tttctgacc  gaaggattt  3660
tatttctac  ggacttggg  acaaattca  cctcagatt  cacagccag  aacggaaga  3720
agtagctcc  ccaggccag  aaatcctaa  tgcggagag  ggtgcgggt  ttgaacgac  3780
ggagatgtg  caaggaagg  ggcattctc  aaatgcttc  taacgcagg  gtgcaagtg  3840
aaccacaca  tttatggaa  cacttagcc  gtgacaggc  catagtagg  cctcaataa  3900
ccatgtttg  ccccctg  3917



<210> 3224
<211> 504
<212> PRT
<213> Rattus norvegicus
<308> AAC37705
<400> 3224

Met Thr Leu Gly Ile Phe Arg Arg Val Phe Leu Met Leu Ser Val Ala 
  1               5                  10                  15
Leu Gly Leu Thr Lys Gly Asp Leu Val Lys Pro Ser Arg Gly Gln Leu 
             20                  25                  30
Val Asn Cys Thr Cys Glu Asn Pro His Cys Lys Arg Pro Ile Cys Gln 
         35                  40                  45
Gly Ala Trp Cys Thr Val Val Leu Val Arg Glu Gln Gly Arg His Pro 
     50                  55                  60
Gln Val Tyr Arg Gly Cys Gly Ser Leu Asn Gln Glu Leu Cys Leu Gly 
 65                  70                  75                  80
Arg Pro Thr Glu Phe Val Asn His His Cys Cys Tyr Arg Ser Phe Cys 
                 85                  90                  95
Asn His Asn Val Ser Leu Met Leu Glu Ala Thr Gln Thr Pro Ser Glu 
             100                105                110
Glu Pro Glu Val Asp Ala His Leu Pro Leu Ile Leu Gly Pro Val Leu 
         115                120                125
Ala Leu Leu Val Leu Val Ala Leu Gly Thr Leu Gly Leu Trp Arg Val 
     130                135                140
Arg Arg Arg Gln Glu Lys Gln Arg Gly Leu His Ser Asp Leu Gly Glu 
 145                150                155                160
Ser Ser Leu Ile Leu Lys Ala Ser Glu Gln Gly Asp Ser Met Leu Gly 
                 165                170                175
Asp Phe Leu Val Ser Asp Cys Thr Thr Gly Ser Gly Ser Gly Leu Pro 
             180                185                190
Phe Leu Val Gln Arg Thr Val Ala Arg Gln Val Ala Leu Val Glu Cys 
         195                200                205
Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg Gly Ser Trp His Gly 
     210                215                220
Glu Ser Val Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser Trp 
 225                230                235                240
Phe Arg Glu Thr Glu Ile Tyr Asn Thr Val Leu Leu Arg His Asp Asn 
                 245                250                255
Ile Leu Gly Phe Ile Ala Ser Asp Met Thr Ser Arg Asn Ser Ser Thr 
             260                265                270
Gln Leu Trp Leu Ile Thr His Tyr His Glu His Gly Ser Leu Tyr Asp 
         275                280                285
Phe Leu Gln Arg Gln Thr Leu Glu Pro Gln Leu Ala Leu Arg Leu Ala 
     290                295                300
Val Ser Ala Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe Gly 
 305                310                315                320
Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Arg Asn 
                 325                330                335
Val Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly Leu 
             340                345                350
Ala Val Met His Ser Gln Ser Ser Asp Tyr Leu Asp Ile Gly Asn Asn 
         355                360                365
Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu 
     370                375                380
Gln Ile Arg Thr Asp Cys Phe Glu Ser Tyr Lys Trp Thr Asp Ile Trp 
 385                390                395                400
Ala Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg Thr Ile Ile Asn 
                 405                410                415
Gly Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Met Val Pro Asn 
             420                425                430
Asp Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln Gln 
         435                440                445
Thr Pro Thr Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser Gly 
     450                455                460
Leu Ala Gln Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala Arg 
 465                470                475                480
Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Gln Lys Leu Ser Gln Asn 
                 485                490                495
Pro Glu Lys Pro Lys Val Ile His 
             500



<210> 3225
<211> 1733
<212> DNA
<213> Homo sapiens
<308> L17075
<400> 3225

tgatttcct  tgggcagga  ggagccacg  ccagcgcgt  tcacacttc  tggctctta  60
tccacctct  ttgctcctc  ctgcaggga  catgacctt  ggctccccc  ggaaaggcc  120
tctgatgct  ctgatggcc  tggtgaccc  gggagaccc  gtgaagccg  ctcggggcc  180
gctggtgac  tgcacgtgt  agagcccac  ttgcaaggg  cctacctgc  ggggggcct  240
gtgcacagt  gtgctggtg  gggaggagg  gaggcaccc  caggaacat  ggggctgcg  300
gaacttgca  agggagctc  gcagggggc  ccccaccga  ttcgtcaac  actactgct  360
cgacagcca  ctctgcaac  acaacgtgt  cctggtgct  gaggccacc  aacctcctt  420
ggagcagcc  ggaacagat  gccagctgg  cctgatcct  ggccccgtg  tggccttgc  480
ggccctggt  gccctgggt  tcctgggcc  gtggcatgt  cgacggagg  aggagaagc  540
gcgtggcct  cacagcgag  tgggagagt  cagtctcat  ctgaaagca  ctgagcagg  600
cgacagcat  ttgggggac  tcctggaca  tgactgcac  acagggagt  gctcagggc  660
ccccttcct  gtgcagagg  cagtggcac  gcaggttgc  ttggtggag  gtgtgggaa  720
aggccgcta  ggcgaagtg  ggcggggct  gtggcacgg  gagagtgtg  ccgtcaaga  780
cttctcctc  agggatgaa  agtcctggt  ccgggagac  gagatctat  acacagtgt  840
gctcagaca  gacaacatc  taggcttca  cgcctcaga  atgacctcc  gcaactcga  900
cacgcagct  tggctcatc  cgcactacc  cgagcacgg  tccctctac  actttctgc  960
gagacagac  ctggagccc  atctggctc  gaggctagc  gtgtccgcg  catgcggcc  1020
ggcgcacct  cacgtggag  tcttcggta  acagggcaa  ccagccatt  cccaccgcg  1080
cttcaagag  cgcaatgtg  tggtcaaga  caacctgca  tgttgcatc  ccgacctgg  1140
cctggctgt  atgcactca  agggcagcg  ttacctgga  atcggcaac  acccgagag  1200
gggcaccaa  cggtacatg  cacccgagg  gctggacga  cagatccgc  cggactgct  1260
tgagtccta  aagtggact  acatctggg  ctttggcct  gtgctgtgg  agattgccc  1320
ccggaccat  gtgaatggc  tcgtggagg  ctatagacc  cccttctat  atgtggtgc  1380
caatgaccc  agctttgag  acatgaaga  ggtggtgtg  gtggatcag  agaccccca  1440
catccctaa  cggctggct  cagacccgg  cctctcagg  ctagctcag  tgatgcggg  1500
gtgctggta  ccaaacccc  ctgcccgac  caccgcgct  cggatcaag  agacactac  1560
aaaaattag  aacagtcca  agaagccta  agtgattca  tagcccagg  gcacctgat  1620
cctttctgc  tgcaggggg  tgggggggt  gggggcagc  gatggtgcc  atctgggta  1680
aggtagtgt  agtgtgtgt  tgctgggat  gcagctgcg  ctgctgctc  ccc  1733



<210> 3226
<211> 503
<212> PRT
<213> Homo sapiens
<308> P37023
<400> 3226

Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala 
  1               5                  10                  15
Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val 
             20                  25                  30
Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly 
         35                  40                  45
Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln 
     50                  55                  60
Glu His Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg 
 65                  70                  75                  80
Pro Thr Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn 
                 85                  90                  95
His Asn Val Ser Leu Val Leu Glu Ala Thr Gln Pro Pro Ser Glu Gln 
             100                105                110
Pro Gly Thr Asp Gly Gln Leu Ala Leu Ile Leu Gly Pro Val Leu Ala 
         115                120                125
Leu Leu Ala Leu Val Ala Leu Gly Val Leu Gly Leu Trp His Val Arg 
     130                135                140
Arg Arg Gln Glu Lys Gln Arg Gly Leu His Ser Glu Leu Gly Glu Ser 
 145                150                155                160
Ser Leu Ile Leu Lys Ala Ser Glu Gln Gly Asp Ser Met Leu Gly Asp 
                 165                170                175
Leu Leu Asp Ser Asp Cys Thr Thr Gly Ser Gly Ser Gly Leu Pro Phe 
             180                185                190
Leu Val Gln Arg Thr Val Ala Arg Gln Val Ala Leu Val Glu Cys Val 
         195                200                205
Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His Gly Glu 
     210                215                220
Ser Val Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser Trp Phe 
 225                230                235                240
Arg Glu Thr Glu Ile Tyr Asn Thr Val Leu Leu Arg His Asp Asn Ile 
                 245                250                255
Leu Gly Phe Ile Ala Ser Asp Met Thr Ser Arg Asn Ser Ser Thr Gln 
             260                265                270
Leu Trp Leu Ile Thr His Tyr His Glu His Gly Ser Leu Tyr Asp Phe 
         275                280                285
Leu Gln Arg Gln Thr Leu Glu Pro His Leu Ala Leu Arg Leu Ala Val 
     290                295                300
Ser Ala Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe Gly Thr 
 305                310                315                320
Gln Gly Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg Asn Val 
                 325                330                335
Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly Leu Ala 
             340                345                350
Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn Asn Pro 
         355                360                365
Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Gln 
     370                375                380
Ile Arg Thr Asp Cys Phe Glu Ser Tyr Lys Trp Thr Asp Ile Trp Ala 
 385                390                395                400
Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg Thr Ile Val Asn Gly 
                 405                410                415
Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro Asn Asp 
             420                425                430
Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln Gln Thr 
         435                440                445
Pro Thr Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser Gly Leu 
     450                455                460
Ala Gln Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala Arg Leu 
 465                470                475                480
Thr Ala Leu Arg Ile Lys Lys Thr Leu Gln Lys Ile Ser Asn Ser Pro 
                 485                490                495
Glu Lys Pro Lys Val Ile Gln 
             500



<210> 3227
<211> 1811
<212> DNA
<213> Rattus norvegicus
<308> L36532
<400> 3227

gcacgagga  cgctgtgag  ggaatggag  cttcttcgc  tctggaccc  gtggggcgc  60
ttgtagcct  ctgccgcgg  ggagtgcat  tggccgtcc  gctgctgtt  ttgtcgcca  120
ctactttgg  ccagtgccc  gccccacca  tgtttcctt  tgccaaacc  ataaatcca  180
ctgatgaat  cacgtttcc  gttggaaca  ctttgaagt  tgaatgtcg  ccaggatat  240
tcaagaggc  gttctctat  acctgcgaa  taaactcag  gtggacaag  cctcaagac  300
tgtgtatac  taaacaatg  gaaactcct  tagatcctc  gaatggcat  gtacatgta  360
acacagaca  ccggtttgg  tcctctatc  cttatacct  taatgaagg  taccgcctc  420
ttggttcct  ctctgctat  tgcataatc  ctgatcaga  cgttgcctg  gatgccgag  480
cacctattt  tgaatcaat  ccttgtgag  tacccccaa  cattcccaa  ggagatttc  540
tcagtccta  cagagaaga  tttcattat  gaatggtag  tacctacca  tgcaacact  600
atgcgagag  gaagaagct  tttaacctg  tgggtgagc  ctccataca  tgtaccagc  660
tcgatggtc  agttggagt  tggagtggc  ctcctcctc  gtgcattga  ctcaacaaa  720
gtactcctc  ccatgttga  aatgcagtc  tagtgtcta  aaacaaaag  ttgttttcc  780
taagggata  ggtggagtt  agatgtcag  atggcttta  gatgaaagg  gacagcagt  840
tgtattgtc  atccctaaa  agatgggag  ctcagttac  aagctgctt  aaggtgaaa  900
cctgtggtg  tttcctggg  gagcttcct  atgggcatg  attcgttcc  caaaatctt  960
aactcgggg  caaagtgac  tttgtttgt  atacagggt  tcaattaaa  ggcaattct  1020
ctagtcatt  tgttcttga  ggagtggaa  gcatttgga  tagcagcgt  cctgtgtgt  1080
aacaagtga  atgtaaact  cctcaggat  tgagtggat  ccagaaagg  ttgcaaatg  1140
aaaaagatt  ttactatgg  gataatgta  ccttggaat  tgaggatgg  tatactcta  1200
aaggcagtt  tcagagcca  tgccagtcc  atgccagct  ggatcctcc  ctgcccaaa  1260
gtgtctctc  agtgatatg  aaactccct  aggatatga  tggattcca  aaagggttg  1320
aaatgaaaa  agattatta  tatggagat  atgtagcct  ggaatgtga  gatgggtat  1380
ctctagaag  cagttctca  agccagtgc  agtccgatg  cagctggga  cctcctctg  1440
ccaaatgtg  ctctcgctc  aacagtggt  taatagctg  aattttcat  gggataatc  1500
tccttattt  attcatcat  ttttcctac  ggatgatta  gaagtttaa  aaacgcaat  1560
ccaccaatg  aaagtgtaa  gaagtgggt  tctatttaa  ttctaaaga  gacagctgt  1620
ttcagcctc  gtctctgct  acaagtcag  agaacaaca  taccagtag  ccagcacgg  1680
attcactca  tcaagaagt  taatagccg  catgtacag  gatgtctct  aaacgcaaa  1740
catttcctg  ctgtatcac  tttaaaata  actattttc  tttaaaatc  agatgtgtt  1800
ttcctcgtg  c  1811



<210> 3228
<211> 559
<212> PRT
<213> Rattus norvegicus
<308> AAA91821
<400> 3228

Met Glu Ala Ser Ser Pro Leu Asp Pro Val Gly Arg Leu Val Ala Phe 
  1               5                  10                  15
Cys Arg Gly Gly Val His Leu Ala Val Leu Leu Leu Phe Leu Ser Pro 
             20                  25                  30
Ser Thr Leu Gly Gln Cys Pro Ala Pro Pro Leu Phe Pro Tyr Ala Lys 
         35                  40                  45
Pro Ile Asn Pro Thr Asp Glu Ser Thr Phe Pro Val Gly Thr Ser Leu 
     50                  55                  60
Lys Tyr Glu Cys Arg Pro Gly Tyr Ile Lys Arg Gln Phe Ser Ile Thr 
 65                  70                  75                  80
Cys Glu Val Asn Ser Val Trp Thr Ser Pro Gln Asp Val Cys Ile Arg 
                 85                  90                  95
Lys Gln Cys Glu Thr Pro Leu Asp Pro Gln Asn Gly Ile Val His Val 
             100                105                110
Asn Thr Asp Ile Arg Phe Gly Ser Ser Ile Thr Tyr Thr Cys Asn Glu 
         115                120                125
Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Met Cys Ile Ile Ser Asp 
     130                135                140
Gln Ser Val Ala Trp Asp Ala Glu Ala Pro Ile Cys Glu Ser Ile Pro 
 145                150                155                160
Cys Glu Ile Pro Pro Ser Ile Pro Asn Gly Asp Phe Phe Ser Pro Asn 
                 165                170                175
Arg Glu Asp Phe His Tyr Gly Met Val Val Thr Tyr Gln Cys Asn Thr 
             180                185                190
Asp Ala Arg Gly Lys Lys Leu Phe Asn Leu Val Gly Glu Pro Ser Ile 
         195                200                205
His Cys Thr Ser Ile Asp Gly Gln Val Gly Val Trp Ser Gly Pro Pro 
     210                215                220
Pro Gln Cys Ile Glu Leu Asn Lys Cys Thr Pro Pro His Val Glu Asn 
 225                230                235                240
Ala Val Ile Val Ser Lys Asn Lys Ser Leu Phe Ser Leu Arg Asp Met 
                 245                250                255
Val Glu Phe Arg Cys Gln Asp Gly Phe Met Met Lys Gly Asp Ser Ser 
             260                265                270
Val Tyr Cys Arg Ser Leu Asn Arg Trp Glu Pro Gln Leu Pro Ser Cys 
         275                280                285
Phe Lys Val Lys Ser Cys Gly Ala Phe Leu Gly Glu Leu Pro Asn Gly 
     290                295                300
His Val Phe Val Pro Gln Asn Leu Gln Leu Gly Ala Lys Val Thr Phe 
 305                310                315                320
Val Cys Asn Thr Gly Tyr Gln Leu Lys Gly Asn Ser Ser Ser His Cys 
                 325                330                335
Val Leu Asp Gly Val Glu Ser Ile Trp Asn Ser Ser Val Pro Val Cys 
             340                345                350
Glu Gln Val Ile Cys Lys Leu Pro Gln Asp Met Ser Gly Phe Gln Lys 
         355                360                365
Gly Leu Gln Met Lys Lys Asp Tyr Tyr Tyr Gly Asp Asn Val Ala Leu 
     370                375                380
Glu Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Ser Gln Ser Gln Cys 
 385                390                395                400
Gln Ser Asp Ala Ser Trp Asp Pro Pro Leu Pro Lys Cys Val Ser Gln 
                 405                410                415
Val Ile Cys Lys Leu Pro Gln Asp Met Ser Gly Phe Gln Lys Gly Leu 
             420                425                430
Gln Met Lys Lys Asp Tyr Tyr Tyr Gly Asp Asn Val Ala Leu Glu Cys 
         435                440                445
Glu Asp Gly Tyr Thr Leu Glu Gly Ser Ser Gln Ser Gln Cys Gln Ser 
     450                455                460
Asp Ala Ser Trp Asp Pro Pro Leu Pro Lys Cys Val Ser Arg Ser Asn 
 465                470                475                480
Ser Gly Leu Ile Ala Gly Ile Phe Ile Gly Ile Ile Val Leu Ile Leu 
                 485                490                495
Phe Ile Ile Phe Ser Tyr Trp Met Ile Met Lys Phe Lys Lys Arg Asn 
             500                505                510
Ser Thr Asn Glu Lys Cys Lys Glu Val Gly Ile Tyr Leu Asn Ser Lys 
         515                520                525
Glu Asp Ser Cys Val Gln Pro Gln Ser Leu Leu Thr Ser Gln Glu Asn 
     530                535                540
Asn Ser Thr Ser Ser Pro Ala Arg Asn Ser Leu Thr Gln Glu Val 
 545                550                555



<210> 3229
<211> 3251
<212> DNA
<213> Homo sapiens
<308> L17418
<400> 3229

gtggaataa  gtttagaaa  tatccaagt  tatctgcct  taaattctg  gtagttcag  60
tgtctacca  gctgttaat  aaatgaaaa  atcctgtta  ttcagggtc  ttccttgac  120
aagtactat  cagctgaag  acatctcga  tacagtttt  gtgggaaag  agccaattg  180
tttcaacag  atcagatct  agcttcata  agtctttga  gtgacttca  agagacgca  240
acatgtgca  ttgaagatg  tgccccttc  ctggtacct  gcaaagctc  tgcctcttt  300
tgtgcgtca  tgtgaaacc  ccacccttc  gcctcgtgc  aaacgcaca  agtatctag  360
caggggaaa  gactgcatt  aggagatag  aaatagttt  gattactta  aggaataag  420
tgttgcctg  aatttctgg  ttgtaaggt  gtcactgtt  ttttttaaa  tatttgtaa  480
atggaatgg  ctcagtaag  agagcttgg  aaatgcaga  agttatgaa  aataagtca  540
ttataatta  gctacctac  gataaccac  cctaatatt  tgattcatt  tctgcctat  600
ttctttcac  tatgtgttt  tttacatac  tccttttcc  cccagtttg  ttcctttta  660
tttatagag  agaacccta  tcttttaaa  cagtttaga  tgaaatata  gctatatca  720
tttttactt  ctctaggga  aaaaattaa  ttactagaa  ggcatgaaa  gatcatggg  780
agagtggtt  agactactg  agagaaata  ttggaaaat  agatttcga  atcttcttt  840
tttttgaga  ggagtctgg  tctgtctcc  aggctggag  gcagtggcg  aatctcggc  900
cactgcaag  tccgcctcc  gggttgaca  cattttcct  cctcagcct  ctgagtagt  960
gggactacc  gtagatggg  ctacaggca  ctgccaaca  gcccggcta  tttttttgt  1020
tttttagta  agacggggt  tcaccatgt  agccaggat  gtctggatc  cctgacctc  1080
tgatccacc  gcctcggcc  cccaaagtg  tgcgattac  ggcatgagc  accgcgcct  1140
gccgctttc  atattttct  aactttaat  caaaagcac  ttgtgctgt  ttctatata  1200
aaaacataa  aaaaattga  atgaaagaa  aattgttat  ataaaagta  tagcttact  1260
ttgtatgga  tcagaatat  ctaaattaa  tttttaaaa  acaactttt  aaaaatgta  1320
caaaaataa  aaacgtgtt  tgatatttt  aaaataagt  accttgtgt  ctttaacca  1380
tccacatct  tagagaaca  aaatgtgtt  tgatattat  ggccatgct  atgacctct  1440
gaaaacatc  gaatatttc  ggatattta  taatagctt  atatatgac  aatgctcat  1500
tctatgtaa  tctgtttaa  agttgcttt  aaggtgaat  ttgccacat  tactttgac  1560
gcagtataa  gagtgagat  gacatgaac  tgaatttca  tttaaaatc  tggaagaga  1620
ggaaaaaaa  ccagcttaa  aaaatcaac  gataaactg  agaaaaaat  caacttaac  1680
tcacaaagc  aatgcttta  tatttagag  gtacttaaa  attaaagac  aaacttctc  1740
ccacccaac  aaaatgggc  aaggacata  agctaggtc  ccaagaaag  agggcaaat  1800
ggtggtgag  acatgtaaa  atacttgat  ggacttttg  ttagttgaa  ctttagcaa  1860
tctctttta  ttcttggga  tttgaagga  ggtaatttt  aaaggagga  tagaaacta  1920
ggtggattt  gggaattgg  ctttttaga  ttaaaattt  ccattacaa  aaaaaaatc  1980
tgtgtcttt  tttccagaa  ggagtaggt  agtgagcaa  gtgattaat  aatatttca  2040
tgtctgtga  ttttgattt  ttttggaga  agggtcttg  tctgttacc  aggctggag  2100
gcagtggtg  tatctaggc  tactgcaac  tcacctgtc  ctttttaat  gcaagaaag  2160
tgaaaggtt  ttttctatt  tatcagtta  aatgagaaa  actgtatat  ctaactatg  2220
gtaaaatac  atattgcct  acttgtatt  ttaagcaat  ctgctaacc  gtgacctta  2280
attttcatc  gaaaagcag  ggctggaca  caattgccc  atgaagcta  tgctagtcc  2340
aacattctt  gttttgttt  cttttttgg  acacttaag  gtgtactat  aagtttatg  2400
tgctttaat  aaattttct  tctctacca  tgtaatgag  aaggaataa  atactttat  2460
ttgcaaatc  acttatgga  tatagttct  tacctgatt  ttttcataa  ccctgtgtt  2520
atgtgtaat  ccacagaca  gctcttgat  gtaacagga  agaaaatca  acacagcta  2580
acataaagg  cagttggct  gcaggtgct  agcaggtgt  aatagaggc  cattcatgc  2640
gctccactt  ctcctgaaa  gcataatgt  aatacagta  actaattag  aggcaaaga  2700
ccatctaac  tggttcttt  ttttttttt  ttttttttt  tgagataaa  tcttgctct  2760
tcaccaggc  ggagtgcag  ggcgcgatc  tgactcact  caacctccg  ctcccaggt  2820
caagcaatt  ccctgcctc  gcctcctga  tagctggga  tacaggtgt  cgccaccac  2880
cccagctaa  tttttgtat  ttagtacag  cggggtttc  ccatgttgg  caggatggt  2940
tagatctcc  gacctcgtg  tctgcccac  tcggcctcc  aaagtgctg  gattacagg  3000
atgagccac  gcgcccagc  ctaacatca  attttaaaa  agttggcca  agtttaatg  3060
catccctgc  caccagcct  cacccatac  gcccttcat  agcccctta  aggagatcc  3120
atagttcta  acccgggtc  acaaacaca  atatcctca  tctctcctt  tcttctctt  3180
ggcagtttg  caaaatctt  agggggaat  ggaggaaac  ttaatctcc  aaatcaact  3240
cattcaaag  t  3251



<210> 3230
<211> 2039
<212> PRT
<213> Homo sapiens
<308> AAB60694
<400> 3230

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
  1               5                  10                  15
Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
             20                  25                  30
Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
         35                  40                  45
Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
     50                  55                  60
Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
 65                  70                  75                  80
Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                 85                  90                  95
Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
             100                105                110
Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
         115                120                125
Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
     130                135                140
Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
 145                150                155                160
Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                 165                170                175
Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
             180                185                190
Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
         195                200                205
Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
     210                215                220
Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
 225                230                235                240
Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                 245                250                255
Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
             260                265                270
Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
         275                280                285
Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
     290                295                300
His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
 305                310                315                320
Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                 325                330                335
Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
             340                345                350
Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
         355                360                365
Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
     370                375                380
Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
 385                390                395                400
Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                 405                410                415
Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
             420                425                430
Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val Asn Tyr 
         435                440                445
Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
     450                455                460
Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
 465                470                475                480
Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                 485                490                495
Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
             500                505                510
Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
         515                520                525
Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
     530                535                540
Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
 545                550                555                560
Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                 565                570                575
Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
             580                585                590
Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
         595                600                605
Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
     610                615                620
Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
 625                630                635                640
Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                 645                650                655
Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
             660                665                670
Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Xaa Pro Asn Lys Cys 
         675                680                685
Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
     690                695                700
Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
 705                710                715                720
Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                 725                730                735
Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
             740                745                750
Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
         755                760                765
Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
     770                775                780
Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
 785                790                795                800
Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                 805                810                815
Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
             820                825                830
Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
         835                840                845
Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
     850                855                860
Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
 865                870                875                880
Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                 885                890                895
Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
             900                905                910
Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
         915                920                925
Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
     930                935                940
Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
 945                950                955                960
Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                 965                970                975
Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
             980                985                990
Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro 
         995                1000                1005
Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp Ile Xaa Val Gly 
     1010                1015                1020
Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His 
 1025                1030                1035                1040
Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr Ala His Trp Ser Thr 
                 1045                1050                1055
Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile 
             1060                1065                1070
Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly 
         1075                1080                1085
Ser Val Val Thr Tyr Arg Cys Asn Leu Gly Ser Arg Gly Arg Lys Val 
     1090                1095                1100
Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp 
 1105                1110                1115                1120
Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn 
                 1125                1130                1135
Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn 
             1140                1145                1150
Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro 
         1155                1160                1165
Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn 
     1170                1175                1180
Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro 
 1185                1190                1195                1200
Pro Glu Ile Leu His Gly Glu His Thr Pro Ser His Gln Asp Asn Phe 
                 1205                1210                1215
Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu 
             1220                1225                1230
Arg Gly Ala Ala Ser Leu His Cys Thr Pro Gln Gly Asp Trp Ser Pro 
         1235                1240                1245
Glu Ala Pro Arg Cys Ala Val Lys Ser Cys Asp Asp Phe Leu Gly Gln 
     1250                1255                1260
Leu Pro His Gly Arg Val Leu Phe Pro Leu Asn Leu Gln Leu Gly Ala 
 1265                1270                1275                1280
Lys Val Ser Phe Val Cys Asp Glu Gly Phe Arg Leu Lys Gly Ser Ser 
                 1285                1290                1295
Val Ser His Cys Val Leu Val Gly Met Arg Ser Leu Trp Asn Asn Ser 
             1300                1305                1310
Val Pro Val Cys Glu His Ile Phe Cys Pro Asn Pro Pro Ala Ile Leu 
         1315                1320                1325
Asn Gly Arg His Thr Gly Thr Pro Ser Gly Asp Ile Pro Tyr Gly Lys 
     1330                1335                1340
Glu Ile Ser Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Met Thr Phe 
 1345                1350                1355                1360
Asn Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro His Gly 
                 1365                1370                1375
Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Glu Leu Ser Val Arg 
             1380                1385                1390
Ala Gly His Cys Lys Thr Pro Glu Gln Phe Pro Phe Ala Ser Pro Thr 
         1395                1400                1405
Ile Pro Ile Asn Asp Phe Glu Phe Pro Val Gly Thr Ser Leu Asn Tyr 
     1410                1415                1420
Glu Cys Arg Pro Gly Tyr Phe Gly Lys Met Phe Ser Ile Ser Cys Leu 
 1425                1430                1435                1440
Glu Asn Leu Val Trp Ser Ser Val Glu Asp Asn Cys Arg Arg Lys Ser 
                 1445                1450                1455
Cys Gly Pro Pro Pro Glu Pro Phe Asn Gly Met Val His Ile Asn Thr 
             1460                1465                1470
Asp Thr Gln Phe Gly Ser Thr Val Asn Tyr Ser Cys Asn Glu Gly Phe 
         1475                1480                1485
Arg Leu Ile Gly Ser Pro Ser Thr Thr Cys Leu Val Ser Gly Asn Asn 
     1490                1495                1500
Val Thr Trp Asp Lys Lys Ala Pro Ile Cys Glu Ile Ile Ser Cys Glu 
 1505                1510                1515                1520
Pro Pro Pro Thr Ile Ser Asn Gly Asp Phe Tyr Ser Asn Asn Arg Thr 
                 1525                1530                1535
Ser Phe His Asn Gly Thr Val Val Thr Tyr Gln Cys His Thr Gly Pro 
             1540                1545                1550
Asp Gly Glu Gln Leu Phe Glu Leu Val Gly Glu Arg Ser Ile Tyr Cys 
         1555                1560                1565
Thr Ser Lys Asp Asp Gln Val Gly Val Trp Ser Ser Pro Pro Pro Arg 
     1570                1575                1580
Cys Ile Ser Thr Asn Lys Cys Thr Ala Pro Glu Val Glu Asn Ala Ile 
 1585                1590                1595                1600
Arg Val Pro Gly Asn Arg Ser Phe Phe Ser Leu Thr Glu Ile Val Arg 
                 1605                1610                1615
Phe Arg Cys Gln Pro Gly Phe Val Met Val Gly Ser His Thr Val Gln 
             1620                1625                1630
Cys Gln Thr Asn Gly Arg Trp Gly Pro Lys Leu Pro His Cys Ser Arg 
         1635                1640                1645
Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His Thr Leu Ser 
     1650                1655                1660
His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
 1665                1670                1675                1680
Pro Ser Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys Thr Pro Gln 
                 1685                1690                1695
Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Thr Val Lys Ser Cys Asp 
             1700                1705                1710
Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Leu Pro Leu Asn 
         1715                1720                1725
Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly Phe Arg 
     1730                1735                1740
Leu Lys Gly Arg Ser Ala Ser His Cys Val Leu Ala Gly Met Lys Ala 
 1745                1750                1755                1760
Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Asn 
                 1765                1770                1775
Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Phe Gly Asp 
             1780                1785                1790
Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Ala Cys Asp Thr His Pro Asp 
         1795                1800                1805
Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Ser Ile Arg Cys Thr 
     1810                1815                1820
Ser Asp Arg Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
 1825                1830                1835                1840
Glu Leu Ser Val Pro Ala Ala Cys Pro Asp Pro Pro Lys Ile Gln Asn 
                 1845                1850                1855
Gly His Tyr Ile Gly Gly His Val Ser Leu Tyr Leu Pro Gly Met Thr 
             1860                1865                1870
Ile Ser Tyr Ile Cys Asp Pro Gly Tyr Leu Leu Val Gly Lys Gly Phe 
         1875                1880                1885
Ile Phe Cys Thr Asp Gln Gly Ile Trp Ser Gln Leu Asp His Tyr Cys 
     1890                1895                1900
Lys Glu Val Asn Cys Ser Phe Pro Leu Phe Met Asn Gly Ile Ser Lys 
 1905                1910                1915                1920
Glu Leu Glu Met Lys Lys Val Tyr His Tyr Gly Asp Tyr Val Thr Leu 
                 1925                1930                1935
Lys Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Pro Trp Ser Gln Cys 
             1940                1945                1950
Gln Ala Asp Asp Arg Trp Asp Pro Pro Leu Ala Lys Cys Thr Ser Arg 
         1955                1960                1965
Ala His Asp Ala Leu Ile Val Gly Thr Leu Ser Gly Thr Ile Phe Phe 
     1970                1975                1980
Ile Leu Leu Ile Ile Phe Leu Ser Trp Ile Ile Leu Lys His Arg Lys 
 1985                1990                1995                2000
Gly Asn Asn Ala His Glu Asn Pro Lys Glu Val Ala Ile His Leu His 
                 2005                2010                2015
Ser Gln Gly Gly Ser Ser Val His Pro Arg Thr Leu Gln Thr Asn Glu 
             2020                2025                2030
Glu Asn Ser Arg Val Leu Pro 
         2035



<210> 3231
<211> 5575
<212> DNA
<213> Rattus norvegicus
<308> L38483
<400> 3231

gtttttttt  ttttttttc  tcccctccc  cccccgcgt  tcatgcagc  gatccgaaa  60
ggaataaaa  gctgcgcat  atcataata  aaaagaagg  gagcgcgag  gaaggaaag  120
aagccgaga  gtggaagag  ggggagcgc  tcaaagaag  gatcagaat  ataaaagga  180
gccgggctc  ttgccttct  gaacgcgcg  ctcttgaaa  ggcttttga  aagtagtgt  240
gttttccag  cgtgcatgc  ccaatccac  gagtatatt  gagccggga  gcggccgtc  300
cgggggcag  gacgacggc  gtcctcgga  ggagcacca  cgctagcag  ggcggcggc  360
tccggagtg  cccccgcgc  gcagcgatg  ggtccccac  gacgcgcgg  cggccgggg  420
gccccttga  ccttctgct  gccctgctc  gtgccctgc  agccaaggt  tgcggggcc  480
cgggtcaat  tgagctgga  atcctgtcc  tgcagaacg  gaacggaga  ttacagaat  540
ggaactgtt  cggcggagc  cggaaccct  gcgaccgca  gtgcacccg  gacgagtgt  600
acacgtact  caaagtgtg  ctcaaggag  atcagtccc  cgtcacggc  gggggaccc  660
gcagcttcg  ctcagggtc  acgcctgtc  tcgggggca  taccttcaa  ctcaaggcc  720
gccgcggca  cgaccgtaa  cgcatcgta  tgcctttca  tttcgcctg  ccgaggtcc  780
acactttgc  ggtggaggc  tgggattcc  gtaatgaca  tattcaacc  gatagcata  840
ttgaaaagg  ttctcactc  ggcatgata  accccagcc  gcagtggca  acactgaaa  900
agaacacag  gattgccca  tttgagtat  agatccgag  gacctgtga  gaccactac  960
atggctttg  ctgcaacaa  ttctgtcgg  ccagagatg  cttctttgg  cattatgcc  1020
gcgaccaga  tggcaacaa  acctgcatg  aaggctgga  gggtcctga  tgtaacaaa  1080
caatatgcc  acagggctg  agtcccaag  atggctcct  caaactccc  ggtgactgc  1140
ggtgccagt  tggttggca  ggcctgtac  gtgataagt  catcccgca  ccaggatgt  1200
tccacggca  ctgcaatga  ccctggcag  gcctctgtg  aaccaactg  ggtggacag  1260
tctgtgaca  agatctgaa  tactgtggg  ctcatcagc  ctgtctcaa  cggggaaca  1320
gtagcaaca  tggccctga  aaataccag  gttcctgcc  cgagggcta  tcaggaccg  1380
actgtgaaa  tgctgagca  gcctgcctc  ctgatccct  ccacaacag  ggcagctgc  1440
aggagacct  ctcgggctt  gagtgtgag  gttctccag  ctggactgg  cccacgtgt  1500
ccacaaaca  cgatgactg  tctccaaat  actgttccc  tggaggcac  tgccaggat  1560
tagtgaatg  attcaagtg  gtgtgccca  cccagtgga  tggcaagac  tgtcagtta  1620
atgcaaatg  gtgcgaggc  aagccttgt  taaatgcca  atcctgtaa  aatctgatt  1680
ccagctact  ctgtgattg  cttcctggc  ggatgggtc  gaattgtga  ataaatatc  1740
atgactgcc  tggccagtg  cagaatgat  cctcctgtc  ggatttggt  aatggttat  1800
gctgtatct  tccacctgg  tatgcgggc  atcactgtg  aagagacat  gatgaatgt  1860
ctagcaacc  ctgcttgaa  gggggtcac  gtcagaatg  aattaacag  ttccagtgt  1920
tgtgtccca  tggtttctc  ggaaacctc  gtcagctgg  catcgatta  tgcgagccc  1980
acccttgcc  gaatggcgc  caatgctac  atcgtgcca  tgactattt  tgcaagtgc  2040
ctgaggact  cgagggcaa  aactgctca  acctgaaag  ccactgccg  accactccc  2100
gtgaagtga  tgacagctg  accgtggcc  tggcctcca  cgatactcc  gaaggggtg  2160
ggtatatct  ttccaacgt  tgtggtccc  atgggaagt  caagagcga  tcaggaggc  2220
aattcacct  tgactgtaa  aaaggcttc  ccggcacct  ctgccatga  aatatcaac  2280
actgtgagg  caacccctg  acgaacggt  gcacgtgca  cgacggcgt  aactcctac  2340
agtgtatct  tagtgacgg  tgggagggc  cgcactgtg  gaacaacat  aatgactgt  2400
gccagaacc  ttgccacta  gggggtaca  gtcgagacc  ggtcaatga  ttttactgt  2460
actgcaaaa  tgggtggaa  gggaaaacc  gccactcgc  tgacagcca  tgtgacgaa  2520
ccacgtgta  taacggtgg  acctgctat  atgaagtgg  tacgtttaa  tgcatgtgt  2580
ctggtggct  ggaaggaac  acctgtaat  tagctagaa  cagtagctg  ctgccgaac  2640
cctgtcata  tggaggcac  tgcgtggtc  atggagact  cttcacctg  gtctgcaaa  2700
aaggctggg  ggggccgat  tgtactcaa  ataccaacg  ctgcagtcc  cacccttgt  2760
acaacagcg  aacctgtgt  gatggagat  actggtacc  gtgcgaatg  gcccctggt  2820
ttgctgggc  agactgcag  ataaacatc  atgagtgtc  gtcttcccc  tgtgccttt  2880
gggccacct  tgtggatga  atcaatggc  accagtgta  ctgccctcc  ggacatagt  2940
gtgccaagt  ccatgaagt  tcagggaga  cttgcatca  catggggag  gtgatactt  3000
atggggcca  gtgggatga  gactgtaac  cctgccagt  cctgaatgg  cgggtggcc  3060
gctccaagg  ctggtgtgg  ccgagacct  gccggctcc  caaagggca  ggcgagtgt  3120
ccaatgggc  gagctgcat  ccagtcctg  atgaccagt  tttcgtgcg  ccctgcact  3180
gtgctggcg  gtgtcggtc  tccagcctc  agccagtga  gaccaagtg  acatcggac  3240
cttattacc  ggacaattg  gcgaacatc  ctttcacct  taacaagga  atgatgtct  3300
caggtctca  cactgagca  atttgcagc  aattgagga  tctgaatat  ctgaagaat  3360
tttctgctg  gtattcaat  tacatagcc  gtgagcctt  cttatcagc  aacaatgaa  3420
tacacgtgg  catttctgc  gaagacatc  gggatgatg  aaaccctgt  aaggaaatt  3480
ctgataaaa  aatagatct  gttagtaaa  gggatggga  cagctcact  atcgctgct  3540
ttgcagaag  cagagttca  aggcgccct  tgaaaaaca  aacagattt  ctggttcct  3600
tgctgagct  tgtcttaac  gtggcttgg  tctgttgct  ggtgacagc  ttctactgg  3660
gtgtgcgga  gcggcggcg  aagcccagc  gccacaccc  ctctgcccc  gaggacaac  3720
ccaccaaca  tgtgcgcga  cagctgaac  aaatcaaaa  ccccatcga  aaacacgga  3780
ccaacacag  ccccatcaa  gattatgag  acaaaaact  caaaatgtc  aaaatcagg  3840
cacacaact  ggaagtgga  gaggatgat  tggataagc  ccagcagaa  gtccggttt  3900
ccaaacagc  cgtgtacac  ctggtagac  gagaggaga  ggtccccca  cgcacgccg  3960
caaaacacc  gaactggac  aacaaacag  acaacagag  cttggaaag  gcccagagc  4020
tgaaccgga  ggagtacat  gtatagcag  cagtgcgtg  cgccatagg  agagtttga  4080
ggcaccccg  ggcttgtag  ttctttaaa  tgttgtcgt  tcccagtct  aggctgttg  4140
tgacttaga  tcctgtgtt  atttaagtt  cgacaagct  gcttccact  gcactggta  4200
tttctgtgg  tggctggga  atcgagtgc  gcgctcaca  ctatgcaaa  accagtgaa  4260
gtgcccggg  gtacattcc  ctgcagccg  ctcgtcggc  cccaggagc  gcccaggcc  4320
aggcctcgg  gcttccaca  ctgccagcg  tcctaatgg  gatggcagc  ttaggatca  4380
agttttatt  atatttatt  actcttgag  tgtttttgt  tattggttt  atgatgacg  4440
acaagtagt  ctgtatttg  aagtgcctt  gcagctcag  accacagca  ctatcacaa  4500
tgactttat  atttatttt  tttattgta  ttttgttgt  gggggaggg  ggatttgat  4560
tcagcagtt  ctggtaaaa  gaagaattt  aagaggaaa  atgtgtcaa  gtagaattt  4620
tgtatagtt  tgtaaataa  tctttttta  taatcactc  gtatatttg  tttattaac  4680
taataatca  gagccttaa  acatcattc  tttttattt  tatgtatgt  tttagaatt  4740
aaggttttt  atagtgttg  aaacatatg  ctttttttt  ttttttttg  gaacttttt  4800
tcattacgt  ttgcctgta  gccaaaagt  aggtgtttg  aaatagttt  tcttggaag  4860
atgggatag  cttcttccc  tgggaatac  gatggattt  ttttttttt  ttttttttt  4920
gtacgacgt  aggtgttca  acacttcct  gatagcatc  ctttaagac  cattctaag  4980
actgactga  gcagattga  aattcgtct  gaacaggtt  ttgtttttt  ctcttttct  5040
tttttattt  ttcctgctt  agacttgaa  agagacagg  aggcgatct  tgacagagc  5100
gtttaaggg  acaaactga  ctatgtagt  agaatgtga  tggttggat  tcattaaaa  5160
tatcagatt  tgtgaagtt  gaagcttac  aatcttact  tgtaaattc  gatttcttt  5220
caccattcg  atgtaatgc  gaaccactt  tagatttga  ttcattgtt  ttgtctact  5280
catttaggg  gtattctaa  aagctagat  aatacttga  ccataaaat  tccagttag  5340
gcactgttt  gattggcca  agagtacac  gcctgcctt  agtgaggac  tgaaagtgc  5400
attaccaag  tcaagatca  aaaaggctt  taaaacagt  atcctggct  accacggag  5460
ccaggaaga  actttgtat  gtcctatta  tgttatatg  acataaaat  catctttga  5520
gtgttgttc  tggcaataa  ttttgaaaa  tgatattta  taaattttt  gtatg  5575



<210> 3232
<211> 1219
<212> PRT
<213> Rattus norvegicus
<308> Q63722
<400> 3232

Met Arg Ser Pro Arg Thr Arg Gly Arg Pro Gly Arg Pro Leu Ser Leu 
  1               5                  10                  15
Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
             20                  25                  30
Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
         35                  40                  45
Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
     50                  55                  60
Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
 65                  70                  75                  80
Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                 85                  90                  95
Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
             100                105                110
Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
         115                120                125
Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
     130                135                140
Thr Ile Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
 145                150                155                160
Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Ile 
                 165                170                175
Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp His Tyr Tyr 
             180                185                190
Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly 
         195                200                205
His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp 
     210                215                220
Met Gly Pro Glu Cys Asn Lys Ala Ile Cys Arg Gln Gly Cys Ser Pro 
 225                230                235                240
Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 
                 245                250                255
Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 
             260                265                270
His Gly Thr Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 
         275                280                285
Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln 
     290                295                300
Pro Cys Leu Asn Arg Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr 
 305                310                315                320
Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala 
                 325                330                335
Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys 
             340                345                350
Glu Thr Ser Ser Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 
         355                360                365
Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 
     370                375                380
His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 
 385                390                395                400
Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys 
                 405                410                415
Glu Ala Lys Pro Cys Val Asn Ala Arg Ser Cys Lys Asn Leu Ile Ala 
             420                425                430
Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp 
         435                440                445
Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys 
     450                455                460
Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala 
 465                470                475                480
Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 
                 485                490                495
Leu Asn Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 
             500                505                510
Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 
         515                520                525
Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala 
     530                535                540
Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys 
 545                550                555                560
Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp 
                 565                570                575
Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg 
             580                585                590
Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Glu 
         595                600                605
Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 
     610                615                620
Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Gly Asn Pro Cys Thr Asn 
 625                630                635                640
Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 
                 645                650                655
Asp Gly Trp Glu Gly Ala His Cys Glu Asn Asn Ile Asn Asp Cys Ser 
             660                665                670
Gln Asn Pro Cys His Tyr Gly Gly Thr Cys Arg Asp Leu Val Asn Asp 
         675                680                685
Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser 
     690                695                700
Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys 
 705                710                715                720
Tyr Asp Glu Val Asp Thr Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 
                 725                730                735
Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 
             740                745                750
Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Asp Ser Phe Thr Cys 
         755                760                765
Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Thr Gln Asn Thr Asn 
     770                775                780
Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly 
 785                790                795                800
Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp 
                 805                810                815
Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly 
             820                825                830
Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Gln Cys Ile Cys Pro Pro 
         835                840                845
Gly His Ser Gly Ala Lys Cys His Glu Val Ser Gly Arg Ser Cys Ile 
     850                855                860
Thr Met Gly Arg Val Ile Leu Asp Gly Ala Lys Trp Asp Asp Asp Cys 
 865                870                875                880
Asn Thr Cys Gln Cys Leu Asn Gly Arg Val Ala Cys Ser Lys Val Trp 
                 885                890                895
Cys Gly Pro Arg Pro Cys Arg Leu His Lys Gly His Gly Glu Cys Pro 
             900                905                910
Asn Gly Gln Ser Cys Ile Pro Val Leu Asp Asp Gln Cys Phe Val Arg 
         915                920                925
Pro Cys Thr Gly Ala Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val 
     930                935                940
Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn 
 945                950                955                960
Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr 
                 965                970                975
Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 
             980                985                990
Ser Ala Glu Tyr Ser Ile Tyr Ile Ala Cys Glu Pro Ser Leu Ser Ala 
         995                1000                1005
Asn Asn Glu Ile His Val Ala Ile Ser Ala Glu Asp Ile Arg Asp Asp 
     1010                1015                1020
Gly Asn Pro Val Lys Glu Ile Thr Asp Lys Ile Ile Asp Leu Val Ser 
 1025                1030                1035                1040
Lys Arg Asp Gly Asn Ser Ser Leu Ile Ala Ala Val Ala Glu Val Arg 
                 1045                1050                1055
Val Gln Arg Arg Pro Leu Lys Asn Arg Thr Asp Phe Leu Val Pro Leu 
             1060                1065                1070
Leu Ser Ser Val Leu Thr Val Ala Trp Val Cys Cys Leu Val Thr Ala 
         1075                1080                1085
Phe Tyr Trp Cys Val Arg Lys Arg Arg Arg Lys Pro Ser Ser His Thr 
     1090                1095                1100
His Ser Ala Pro Glu Asp Asn Thr Thr Asn Asn Val Arg Glu Gln Leu 
 1105                1110                1115                1120
Asn Gln Ile Lys Asn Pro Ile Glu Lys His Gly Ala Asn Thr Val Pro 
                 1125                1130                1135
Ile Lys Asp Tyr Glu Asn Lys Asn Ser Lys Met Ser Lys Ile Arg Thr 
             1140                1145                1150
His Asn Ser Glu Val Glu Glu Asp Asp Met Asp Lys His Gln Gln Lys 
         1155                1160                1165
Val Arg Phe Ala Lys Gln Pro Val Tyr Thr Leu Val Asp Arg Glu Glu 
     1170                1175                1180
Lys Val Pro Gln Arg Thr Pro Thr Lys His Pro Asn Trp Thr Asn Lys 
 1185                1190                1195                1200
Gln Asp Asn Arg Asp Leu Glu Ser Ala Gln Ser Leu Asn Arg Met Glu 
                 1205                1210                1215
Tyr Ile Val 
             1220



<210> 3233
<211> 5077
<212> DNA
<213> Homo sapiens
<308> NM_002226
<400> 3233

ctcatgcat  tgcaggtgc  cgggtgacg  atgggcgag  gagctgtca  tctcgttcc  60
aacttgttg  ctgcggtgc  gggagcgcg  gcgcgcaga  ccgaggccg  gacccgctg  120
cttcaccgc  gccgccgtc  ccgccgggt  ggagccggg  cgggcagcc  gagcgcggc  180
gccagcgag  cggagctgc  gccgcccct  cacgcccgc  gcccaggcc  gcgcgccgc  240
gcgctgcgc  cgaccccgc  cgcgccgcc  ccgccgccg  ctctgccgc  gccgctgcc  300
ctgcgggcg  tcggagggc  ggcgggcgc  gggaggccg  cgcggcggc  gggagccgg  360
cgcgggcgg  ggcggcggg  ccgggcggg  gggtcgcgg  ggcaatgcg  gcgcagggc  420
gggggcgcc  tccccggcg  ctgctgctg  tgctggcgc  ctgggtgca  gcggcgcgg  480
ccatgggct  tttcgagct  cagctgagc  cgctgcgga  cgtgaacgg  gagctgctg  540
gcggcgcct  ctgtgacgg  gacggccgg  caacgcgcg  ggggggctg  ggccacgac  600
agtgcgaca  gtacgtgcg  gtgtgcctt  aggagtacc  ggccaaggt  acgcccacg  660
ggccctgca  ctacggcca  ggcgccacg  ccgtgctgg  cggcaactc  ttctacctg  720
cgccggcgg  cgctgcggg  gaccgagcg  gggcgcggg  ccgggccgg  ggcgaccag  780
acccgggcc  cgtcgtcat  cccttccag  tcgcctggc  gcgctcctt  accctcatc  840
tggaggcct  ggactggga  aacgatacc  ccccgaatg  ggagctgct  atcgagcga  900
tgtcgcatg  cggcatgat  aacccggag  accgctgga  gagcctgca  ttcagcggc  960
acgtggcgc  cctggagct  cagatccgc  tgcgctgcg  cgagaacta  tacagcgcc  1020
cttgcaaca  gttctgccg  ccccgcaac  actttttcg  ccactacac  tgcgaccag  1080
acggcaaca  ggcctgcat  gacggctgg  tgggcaagg  gtgcaagga  gctgtgtgt  1140
aacaagggt  taatttgct  cacggggga  gcaccgtgc  tggggagtg  aggtgcagc  1200
acggctggc  agggaggtt  tgcgatgag  gtgtcccct  ccccggctg  gtgcatggc  1260
gttgtgtgg  gccctggca  tgcaactgt  agaccaact  gggcggcct  ctctgtgac  1320
aagacctga  ctactgtgg  agccaccac  cctgcacca  cggaggcac  tgcatcaac  1380
ccgagcctg  ccagtaccg  tgcacctgc  ctgacggct  ctcgggcag  aactgtgag  1440
aggctgagc  cgcctgcac  tccaacccg  gtgccaacg  gggctcttg  catgaggtg  1500
cgtccggct  cgaatgcca  tgcccatcg  gctggagcg  gcccacctg  gcccttgac  1560
tcgatgagt  tgcttcgaa  ccgtgtgcg  ccggtggca  ctgtgtgga  caggtggac  1620
gctttgagt  catctgccc  gagcagtgg  tgggggcca  ctgccagct  gacgccaat  1680
agtgtgaag  gaagccatg  cttaacgct  tttcttgca  aaacctgat  ggcggctat  1740
actgtgatt  catcccggg  tggaagggc  tcaactgcc  tatcaacgt  aacgactgt  1800
gcgggcagt  tcagcatgg  ggcacctgc  aggacctgg  gaacgggta  cagtgtgtg  1860
gcccacggg  cttcggagg  cggcattgc  agctggaac  agacgagtg  gccagcagc  1920
cctgccaca  cggcggcct  tgcgaggac  tggccgacg  cttccactg  cactgcccc  1980
agggcttct  cgggcctct  tgtgaggtg  atgtcgacc  ttgtgagcc  agcccctgc  2040
ggaacggcg  tcgctgcta  aacctggag  gtgactatt  ctgcgcctg  cctgatgac  2100
ttggtggca  gaactgctc  gtgccccgc  agccgtgcc  tggcggggc  tgcagagtg  2160
tcgatggct  cgggtcaga  gcggggcct  ggatgcctg  cacagcagc  tccggcgtg  2220
gtggccccc  tggacgctg  gtcagccag  cagggggca  cttttcctg  atctgtgac  2280
gtggcttta  tggcaccta  tgccatgag  acattgacg  ctgcctggg  cagccctgc  2340
gcaatgggg  cacatgcat  gatgaggtg  acgccttcc  ctgcttctg  cccagcggc  2400
gggagggcg  gctctgcga  accaatccc  acgactgcc  tcccgatcc  tgccacagc  2460
gcggccgct  ctacgacct  gtcaatgac  tctactgtg  gtgcgacga  ggctggaag  2520
gcaagacct  ccactcacg  gagttccag  gcgatgcct  cacctgcag  aacggtggc  2580
cctgctacg  cagcggcga  accttccgc  gcgcctgcc  ccccggctg  aagggcagc  2640
cctgcgccg  cgccaagaa  agcagctgc  tgcccaacc  ctgtgtgaa  ggtggcacc  2700
gcgtgggca  cggggcctc  ttctcctgc  tctgccggg  cggctggga  ggtcgtact  2760
gcactcaca  taccaacga  tgcaaccct  tgccttgct  caatggtgg  atctgtgtt  2820
acggcgtca  ctggttccg  tgcgagtgt  cacctggct  cgcggggcc  gactgccgc  2880
tcaacatcg  cgagtgcca  tcctcgccc  gtgcctacg  ggccacgtg  gtggatgag  2940
tcaacgggt  tcgctgtag  tgcccaccc  gccgagccg  cccccggtg  caggaagtg  3000
tcgggttcg  gagatcctg  tggtcccgg  gcactccgt  cccacacgg  agctcctgg  3060
tggaagact  caacagctg  cgctgcctg  atggccgcc  tgactgcag  aaggtgtgg  3120
gcggatgga  gccttgtct  ctggccggc  agcccgagg  cctgagcgc  cagtgccca  3180
tggggcaaa  gtgcctgga  aaggcccca  gccagtgtc  gcgaccacc  tgtgaggcc  3240
ggggggagt  cggcgcaga  gagccaccg  gcaccccct  cctgccacg  tccggccac  3300
tggacaata  ctgtgcccg  ctcaccttg  atttcaacc  tgaccacgt  ccccagggc  3360
ccacggtgg  cgccatttg  tccgggatc  gctccctgc  agccacaag  gctgtggca  3420
gggaccgcc  gctggtgtt  ctttgcgac  gggcgtcct  gggggccag  gccgtggag  3480
tggccgtgt  cttcagccc  gccagggac  tgcctgaca  cagcctgat  cagggcgcg  3540
cccacgcca  cgtggccgc  atcacccag  gggggaaca  ctcactgct  ctggctgtc  3600
ccgaggtca  ggtggagac  gttgttacg  gcggctctt  cacaggtct  ctggtgcct  3660
tgctgtgtg  tgccttcag  gtgctgtgg  tggcgtgcg  ggtcctgtg  gtgtggtgg  3720
cacgcaagc  caggaaaga  cgggagagg  gccggctgc  gcgggagga  agcgccaac  3780
accagtggg  cccgctcaa  cccatccgc  accccatcg  gcggccggg  ggccacaag  3840
acgtgctct  ccagtgcaa  aacttcacg  cgccgccgc  cagggcgga  gaggcgctg  3900
ccgggccgg  cggccacgc  gccgtcagg  aggatgagg  ggacgagga  ctgggccgc  3960
gtgaggagg  ctccctgga  gcggagaag  tcctctcac  caaattcac  aaagatcct  4020
gccgctcgc  ggggaggcc  gcccactgg  cctcaggcc  caaagtgga  aaccgcgcg  4080
tcaggagca  caatgaggc  cgctacgcc  gcaaggagt  ggggcggct  ccagctggg  4140
cgggaccca  ggccctcgg  gggagccat  ccgtctgcc  gacccggag  ccgaggcca  4200
gtgcatagt  tctttattt  gtgtaaaaa  accaccaaa  acaaaaacc  aatgtttat  4260
ttctacgtt  ctttaacct  gtataaatt  ttcagtaac  gtcaggctg  aaacaatgg  4320
gtattctcg  atagttgct  tttttgtaa  gtttccgtg  gtggcactc  ctgtatgaa  4380
ggagagagc  aagggtgtc  gcgtcgtca  caaatcgta  cgtttgtta  cagaggttg  4440
gcactgttt  cagaatctt  cttttattc  tcactcggg  ttctctgtg  ctccaggcc  4500
aagtgccgg  gagacccat  gctgtgttg  tgtggccca  ggctgttgg  gggacccgt  4560
gctgatggt  tggcctgtg  ctgtcggtg  gactcgtgg  tgtcaatgg  acctgtggc  4620
gtcggtggg  cctacggtg  tcggtggga  cctggttat  gatgtggcc  tggctgccg  4680
cacggcccg  ggctgttga  gcacctgtg  ttgttagtg  ggcctgagg  catcggcgt  4740
gcccaaggc  ggcaggtca  cctcgcgct  gctggccag  ccaccctgc  tgccgtctg  4800
gcttcctcc  gcccagaac  cccgctcca  cgatctctc  actgtgctt  cagaagtgc  4860
cttcctgct  cgcagttct  ccatcctgg  acggcggca  tattgaagc  cgtgacaag  4920
gccttcaca  agacccctc  caactgtcc  cgcgtgccg  ggcaccagg  gctgcccac  4980
tgccggccc  ggccgcccc  cctcgtgaa  gtgcatttt  gtaaatgtg  acatattaa  5040
ggaagcact  tgtatattt  attgaataa  gccacca  5077



<210> 3234
<211> 1238
<212> PRT
<213> Homo sapiens
<308> Q9Y219
<400> 3234

Met Arg Ala Gln Gly Arg Gly Arg Leu Pro Arg Arg Leu Leu Leu Leu 
  1               5                  10                  15
Leu Ala Leu Trp Val Gln Ala Ala Arg Pro Met Gly Tyr Phe Glu Leu 
             20                  25                  30
Gln Leu Ser Ala Leu Arg Asn Val Asn Gly Glu Leu Leu Ser Gly Ala 
         35                  40                  45
Cys Cys Asp Gly Asp Gly Arg Thr Thr Arg Ala Gly Gly Cys Gly His 
     50                  55                  60
Asp Glu Cys Asp Thr Tyr Val Arg Val Cys Leu Lys Glu Tyr Gln Ala 
 65                  70                  75                  80
Lys Val Thr Pro Thr Gly Pro Cys Ser Tyr Gly His Gly Ala Thr Pro 
                 85                  90                  95
Val Leu Gly Gly Asn Ser Phe Tyr Leu Pro Pro Ala Gly Ala Ala Gly 
             100                105                110
Asp Arg Ala Arg Ala Arg Ala Arg Ala Gly Gly Asp Gln Asp Pro Gly 
         115                120                125
Leu Val Val Ile Pro Phe Gln Phe Ala Trp Pro Arg Ser Phe Thr Leu 
     130                135                140
Ile Val Glu Ala Trp Asp Trp Asp Asn Asp Thr Thr Pro Asn Glu Glu 
 145                150                155                160
Leu Leu Ile Glu Arg Val Ser His Ala Gly Met Ile Asn Pro Glu Asp 
                 165                170                175
Arg Trp Lys Ser Leu His Phe Ser Gly His Val Ala His Leu Glu Leu 
             180                185                190
Gln Ile Arg Val Arg Cys Asp Glu Asn Tyr Tyr Ser Ala Thr Cys Asn 
         195                200                205
Lys Phe Cys Arg Pro Arg Asn Asp Phe Phe Gly His Tyr Thr Cys Asp 
     210                215                220
Gln Tyr Gly Asn Lys Ala Cys Met Asp Gly Trp Met Gly Lys Glu Cys 
 225                230                235                240
Lys Glu Ala Val Cys Lys Gln Gly Cys Asn Leu Leu His Gly Gly Cys 
                 245                250                255
Thr Val Pro Gly Glu Cys Arg Cys Ser Tyr Gly Trp Gln Gly Arg Phe 
             260                265                270
Cys Asp Glu Cys Val Pro Tyr Pro Gly Cys Val His Gly Ser Cys Val 
         275                280                285
Glu Pro Trp Gln Cys Asn Cys Glu Thr Asn Trp Gly Gly Leu Leu Cys 
     290                295                300
Asp Lys Asp Leu Asn Tyr Cys Gly Ser His His Pro Cys Thr Asn Gly 
 305                310                315                320
Gly Thr Cys Ile Asn Ala Glu Pro Asp Gln Tyr Arg Cys Thr Cys Pro 
                 325                330                335
Asp Gly Tyr Ser Gly Arg Asn Cys Glu Lys Ala Glu His Ala Cys Thr 
             340                345                350
Ser Asn Pro Cys Ala Asn Gly Gly Ser Cys His Glu Val Pro Ser Gly 
         355                360                365
Phe Glu Cys His Cys Pro Ser Gly Trp Ser Gly Pro Thr Cys Ala Leu 
     370                375                380
Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys Ala Ala Gly Gly Thr Cys 
 385                390                395                400
Val Asp Gln Val Asp Gly Phe Glu Cys Ile Cys Pro Glu Gln Trp Val 
                 405                410                415
Gly Ala Thr Cys Gln Leu Asp Ala Asn Glu Cys Glu Gly Lys Pro Cys 
             420                425                430
Leu Asn Ala Phe Ser Cys Lys Asn Leu Ile Gly Gly Tyr Tyr Cys Asp 
         435                440                445
Cys Ile Pro Gly Trp Lys Gly Ile Asn Cys His Ile Asn Val Asn Asp 
     450                455                460
Cys Arg Gly Gln Cys Gln His Gly Gly Thr Cys Lys Asp Leu Val Asn 
 465                470                475                480
Gly Tyr Gln Cys Val Cys Pro Arg Gly Phe Gly Gly Arg His Cys Glu 
                 485                490                495
Leu Glu Arg Asp Lys Cys Ala Ser Ser Pro Cys His Ser Gly Gly Leu 
             500                505                510
Cys Glu Asp Leu Ala Asp Gly Phe His Cys His Cys Pro Gln Gly Phe 
         515                520                525
Ser Gly Pro Leu Cys Glu Val Asp Val Asp Leu Cys Glu Pro Ser Pro 
     530                535                540
Cys Arg Asn Gly Ala Arg Cys Tyr Asn Leu Glu Gly Asp Tyr Tyr Cys 
 545                550                555                560
Ala Cys Pro Asp Asp Phe Gly Gly Lys Asn Cys Ser Val Pro Arg Glu 
                 565                570                575
Pro Cys Pro Gly Gly Ala Cys Arg Val Ile Asp Gly Cys Gly Ser Asp 
             580                585                590
Ala Gly Pro Gly Met Pro Gly Thr Ala Ala Ser Gly Val Cys Gly Pro 
         595                600                605
His Gly Arg Cys Val Ser Gln Pro Gly Gly Asn Phe Ser Cys Ile Cys 
     610                615                620
Asp Ser Gly Phe Thr Gly Thr Tyr Cys His Glu Asn Ile Asp Asp Cys 
 625                630                635                640
Leu Gly Gln Pro Cys Arg Asn Gly Gly Thr Cys Ile Asp Glu Val Asp 
                 645                650                655
Ala Phe Arg Cys Phe Cys Pro Ser Gly Trp Glu Gly Glu Leu Cys Asp 
             660                665                670
Thr Asn Pro Asn Asp Cys Leu Pro Asp Pro Cys His Ser Arg Gly Arg 
         675                680                685
Cys Tyr Asp Leu Val Asn Asp Phe Tyr Cys Ala Cys Asp Asp Gly Trp 
     690                695                700
Lys Gly Lys Thr Cys His Ser Arg Glu Phe Gln Cys Asp Ala Tyr Thr 
 705                710                715                720
Cys Ser Asn Gly Gly Thr Cys Tyr Asp Ser Gly Asp Thr Phe Arg Cys 
                 725                730                735
Ala Cys Pro Pro Gly Trp Lys Gly Ser Thr Cys Ala Val Ala Lys Asn 
             740                745                750
Ser Ser Cys Leu Pro Asn Pro Cys Val Asn Gly Gly Thr Cys Val Gly 
         755                760                765
Ser Gly Ala Ser Phe Ser Cys Ile Cys Arg Asp Gly Trp Glu Gly Arg 
     770                775                780
Thr Cys Thr His Asn Thr Asn Asp Cys Asn Pro Leu Pro Cys Tyr Asn 
 785                790                795                800
Gly Gly Ile Cys Val Asp Gly Val Asn Trp Phe Arg Cys Glu Cys Ala 
                 805                810                815
Pro Gly Phe Ala Gly Pro Asp Cys Arg Ile Asn Ile Asp Glu Cys Gln 
             820                825                830
Ser Ser Pro Cys Ala Tyr Gly Ala Thr Cys Val Asp Glu Ile Asn Gly 
         835                840                845
Tyr Arg Cys Ser Cys Pro Pro Gly Arg Ala Gly Pro Arg Cys Gln Glu 
     850                855                860
Val Ile Gly Phe Gly Arg Ser Cys Trp Ser Arg Gly Thr Pro Phe Pro 
 865                870                875                880
His Gly Ser Ser Trp Val Glu Asp Cys Asn Ser Cys Arg Cys Leu Asp 
                 885                890                895
Gly Arg Arg Asp Cys Ser Lys Val Trp Cys Gly Trp Lys Pro Cys Leu 
             900                905                910
Leu Ala Gly Gln Pro Glu Ala Leu Ser Ala Gln Cys Pro Leu Gly Gln 
         915                920                925
Arg Cys Leu Glu Lys Ala Pro Gly Gln Cys Leu Arg Pro Pro Cys Glu 
     930                935                940
Ala Trp Gly Glu Cys Gly Ala Glu Glu Pro Pro Ser Thr Pro Cys Leu 
 945                950                955                960
Pro Arg Ser Gly His Leu Asp Asn Asn Cys Ala Arg Leu Thr Leu His 
                 965                970                975
Phe Asn Arg Asp His Val Pro Gln Gly Thr Thr Val Gly Ala Ile Cys 
             980                985                990
Ser Gly Ile Arg Ser Leu Pro Ala Thr Arg Ala Val Ala Arg Asp Arg 
         995                1000                1005
Leu Leu Val Leu Leu Cys Asp Arg Ala Ser Ser Gly Ala Ser Ala Val 
     1010                1015                1020
Glu Val Ala Val Ser Phe Ser Pro Ala Arg Asp Leu Pro Asp Ser Ser 
 1025                1030                1035                1040
Leu Ile Gln Gly Ala Ala His Ala Ile Val Ala Ala Ile Thr Gln Arg 
                 1045                1050                1055
Gly Asn Ser Ser Leu Leu Leu Ala Val Thr Glu Val Lys Val Glu Thr 
             1060                1065                1070
Val Val Thr Gly Gly Ser Ser Thr Gly Leu Leu Val Pro Val Leu Cys 
         1075                1080                1085
Gly Ala Phe Ser Val Leu Trp Leu Ala Cys Val Val Leu Cys Val Trp 
     1090                1095                1100
Trp Thr Arg Lys Arg Arg Lys Glu Arg Glu Arg Ser Arg Leu Pro Arg 
 1105                1110                1115                1120
Glu Glu Ser Ala Asn Asn Gln Trp Ala Pro Leu Asn Pro Ile Arg Asn 
                 1125                1130                1135
Pro Ile Glu Arg Pro Gly Gly His Lys Asp Val Leu Tyr Gln Cys Lys 
             1140                1145                1150
Asn Phe Thr Pro Pro Pro Arg Arg Ala Asp Glu Ala Leu Pro Gly Pro 
         1155                1160                1165
Ala Gly His Ala Ala Val Arg Glu Asp Glu Glu Asp Glu Asp Leu Gly 
     1170                1175                1180
Arg Gly Glu Glu Asp Ser Leu Glu Ala Glu Lys Phe Leu Ser His Lys 
 1185                1190                1195                1200
Phe Thr Lys Asp Pro Gly Arg Ser Pro Gly Arg Pro Ala His Trp Ala 
                 1205                1210                1215
Ser Gly Pro Lys Val Asp Asn Arg Ala Val Arg Ser Ile Asn Glu Ala 
             1220                1225                1230
Arg Tyr Ala Gly Lys Glu 
         1235



<210> 3235
<211> 1882
<212> DNA
<213> Rattus norvegicus
<308> L38615
<400> 3235

tggagtttg  gcttggcga  cagctggac  acgagcgag  tgggatggc  accagctgg  60
gaagcatct  gcaggatga  aagcagctg  aagagttgg  acagcaggc  atagaccgg  120
ccctggctg  gggggtgtt  ctgaggtcc  caaagaacc  cagctcctc  gacgtggtg  180
cgtatgccc  attcacgct  ttcccctca  cagtgccca  cactctgct  gagcaggcc  240
atgctgtgc  gatggactt  aacatcctg  tagatgctg  cagccagaa  tccgccttc  300
tggagcaaa  actgtctag  accatcaaa  aggatgagt  tactgcccg  ctctttgat  360
tctacaagc  agtcctgaa  gagggcata  cccagactg  gttcctggg  ctcaatcgt  420
cagattaca  gttccagtg  agcgcagac  gctccaaag  cctgaaaca  attgagatc  480
acactatct  tgccagctt  gggggcctg  cctcccgga  tccggctgt  caccgacat  540
ttctcaatg  cctgaataa  accaacgaa  cttccaaga  cctgtccaa  aaccccagc  600
agggactgg  cctggggat  gccaaagcc  gggagctct  tggctcagc  aatgccgtg  660
tgctactga  tgctcagga  aaggaaagg  acatatttg  ccagcgtgc  atagagaac  720
agctgctag  caggaagat  catgtaatc  gccgaagat  tgaagatgt  tctgaaagg  780
gttctctag  ccaaaaccg  aggctgttt  tggaggacc  ggaagttgc  gtggtttac  840
tccgagatg  ctacatgcc  agtcagtat  acgcacaga  ctgggaagc  cgcctgctg  900
tagagagat  atgtgctgc  aagtgtccc  acattgcca  acagctggc  ggcactaag  960
aggtgcagc  ggaactgag  agggtgggc  tgctggaag  gctgctccc  ggccagccc  1020
aggctgtgg  ccgcctccg  gccaccttt  ctggcctct  ttcactgga  atgggtgaa  1080
aaggggacc  ggctgtcgc  gaggccctt  ctgccccta  ccactttgt  ctgaagccc  1140
aaagagagg  cggaggtaa  aacttctat  gggaggaaa  ggtacacgc  ctggagcag  1200
tgaaagaca  cgaggagag  gcctcctac  tcctcatgg  gaagattga  cctgagcct  1260
ttaggaatt  cttactacg  cctggcagc  ctgcccaag  ggtccagtg  atctcggag  1320
tgggtattt  tggagtcta  gtcagacag  gaacaacac  tgtgatgaa  aagcatgtg  1380
ggcatctgc  tcgaaccaa  gccattgaa  atgcagatg  aggtgtggc  gcaggagtg  1440
cagtcctgg  caaccccta  cctgtgtga  gacatgttc  gggcttcac  caagagacc  1500
tctatcctc  gtacttggc  ctcctctcc  gaggggcta  ccctgtacc  gtgttaggg  1560
agggagctt  tctctttca  agacctcca  gggctttag  gaagggaaa  tcccgggtc  1620
cttctctca  ccttccatc  aaggaccag  aaagctatg  ttccattgg  agagttctg  1680
agctcccca  atttggagt  ggaatggaa  ctcctttga  gcaaaggcc  acaaacccc  1740
cacatcttc  ttgccctct  gccagcctt  ccagcaggt  ctagtgcct  gacctgggg  1800
aggaccaag  gacaggagg  agagggtag  tgggcatag  cttccccag  tctgcccta  1860
ataaaacaa  gctgattca  tg  1882



<210> 3236
<211> 474
<212> PRT
<213> Rattus norvegicus
<308> P46413
<400> 3236

Met Ala Thr Ser Trp Gly Ser Ile Leu Gln Asp Glu Lys Gln Leu Glu 
  1               5                  10                  15
Glu Leu Ala Gln Gln Ala Ile Asp Arg Ala Leu Ala Glu Gly Val Leu 
             20                  25                  30
Leu Arg Ser Ala Lys Asn Pro Ser Ser Ser Asp Val Val Thr Tyr Ala 
         35                  40                  45
Pro Phe Thr Leu Phe Pro Ser Pro Val Pro Ser Thr Leu Leu Glu Gln 
     50                  55                  60
Ala Tyr Ala Val Gln Met Asp Phe Asn Ile Leu Val Asp Ala Val Ser 
 65                  70                  75                  80
Gln Asn Ser Ala Phe Leu Glu Gln Thr Leu Ser Ser Thr Ile Lys Lys 
                 85                  90                  95
Asp Glu Tyr Thr Ala Arg Leu Phe Asp Ile Tyr Lys Gln Val Leu Lys 
             100                105                110
Glu Gly Ile Ala Gln Thr Val Phe Leu Gly Leu Asn Arg Ser Asp Tyr 
         115                120                125
Met Phe Gln Cys Ser Ala Asp Gly Ser Lys Ala Leu Lys Gln Ile Glu 
     130                135                140
Ile Asn Thr Ile Ser Ala Ser Phe Gly Gly Leu Ala Ser Arg Thr Pro 
 145                150                155                160
Ala Val His Arg His Val Leu Asn Val Leu Asn Lys Thr Asn Glu Ala 
                 165                170                175
Ser Lys Ile Leu Ser Asn Asn Pro Ser Lys Gly Leu Ala Leu Gly Ile 
             180                185                190
Ala Lys Ala Trp Glu Leu Tyr Gly Ser Ala Asn Ala Val Val Leu Leu 
         195                200                205
Ile Ala Gln Glu Lys Glu Arg Asn Ile Phe Asp Gln Arg Ala Ile Glu 
     210                215                220
Asn Glu Leu Leu Asp Arg Lys Ile His Val Ile Arg Arg Arg Phe Glu 
 225                230                235                240
Asp Val Ser Glu Arg Gly Ser Leu Asp Gln Asn Arg Arg Leu Phe Met 
                 245                250                255
Glu Asp Gln Glu Val Ala Val Val Tyr Phe Arg Asp Gly Tyr Met Pro 
             260                265                270
Ser Gln Tyr Asn Ala Gln Asn Trp Glu Ala Arg Leu Leu Leu Glu Arg 
         275                280                285
Ser Cys Ala Ala Lys Cys Pro Asp Ile Ala Thr Gln Leu Ala Gly Thr 
     290                295                300
Lys Lys Val Gln Gln Glu Leu Ser Arg Val Gly Leu Leu Glu Ala Leu 
 305                310                315                320
Leu Pro Gly Gln Pro Glu Ala Val Ala Arg Leu Arg Ala Thr Phe Ala 
                 325                330                335
Gly Leu Tyr Ser Leu Asp Met Gly Glu Glu Gly Asp Gln Ala Val Ala 
             340                345                350
Glu Ala Leu Ala Ala Pro Ser His Phe Val Leu Lys Pro Gln Arg Glu 
         355                360                365
Gly Gly Gly Asn Asn Phe Tyr Gly Glu Glu Met Val His Ala Leu Glu 
     370                375                380
Gln Leu Lys Asp Ser Glu Glu Arg Ala Ser Tyr Ile Leu Met Glu Lys 
 385                390                395                400
Ile Glu Pro Glu Pro Phe Arg Asn Cys Leu Leu Arg Pro Gly Ser Pro 
                 405                410                415
Ala Gln Val Val Gln Cys Ile Ser Glu Leu Gly Ile Phe Gly Val Tyr 
             420                425                430
Val Arg Gln Gly Thr Thr Leu Val Met Asn Lys His Val Gly His Leu 
         435                440                445
Leu Arg Thr Lys Ala Ile Glu His Ala Asp Gly Gly Val Ala Ala Gly 
     450                455                460
Val Ala Val Leu Asp Asn Pro Tyr Pro Val 
 465                470



<210> 3237
<211> 1856
<212> DNA
<213> Homo sapiens
<308> NM_000178
<400> 3237

gggagaacc  ttcgcggag  aaaggcgaa  tagtgttgg  atggccacc  actggggga  60
cctcttgca  gataaacag  agctagagg  gctggcacg  caggccgtg  accgggccc  120
ggctgaggg  gtattgctg  ggacctcac  ggagcccac  tcctcggag  tggtgagct  180
tgccccatt  acgctcttc  cctcactgg  ccccagtgc  ctgctggag  aagcctatg  240
tgtgcagat  gacttcaac  tgctagtgg  tgctgtcag  cagaacgct  ccttcctgg  300
gcaaactct  tccagcacc  tcaaacagg  tgactttac  gctcgtctc  ttgacatcc  360
caagcaagt  ctaaaagag  gcattgccc  gactgtgtt  ctgggcctg  atcgctcag  420
ctacatgtt  cagcgcagc  cagatggct  cccagccct  aaacagatc  aaatcaaca  480
catctctgc  agctttggg  gcctggcct  ccggacccc  gctgtgcac  gacatgttc  540
cagtgtcct  agtaagacc  aagaagctg  caagatcct  tctaataat  ccagcaagg  600
actggccct  ggaattgcc  aagcctggg  gctctacgg  tcacccaat  ctctggtgc  660
actgattgc  caagagaag  aaagaaaca  atttgacca  cgtgccata  agaatgagc  720
actggccag  aacatccat  tgatccgac  aacatttga  gatatctct  aaaaggggt  780
tctggacca  gaccgaagg  tgtttgtgg  tggccagga  attgctgtg  tttacttcc  840
ggatggcta  atgcctcgt  agtacagtc  acagaattg  gaagcacgt  tactgctgg  900
gaggtcaca  gctgccaag  gcccagaca  tgccaccca  ctggctggg  ctaagaagg  960
gcagcagga  ctaagcagg  cgggcatgc  ggagatgtt  ctccctggc  agcctgagg  1020
tgtggcccg  ctccgcgcc  cctttgctg  cctctactc  ctggatgtg  gtgaagaag  1080
ggaccaggc  atcgccgag  cccttgctg  ccctagccg  tttgtgcta  agccccaga  1140
agagggtgg  ggtaacaac  tatatgggg  ggaaatggt  caggccctg  aacagctga  1200
ggacagtga  gagagggcc  cctacatcc  catggagaa  atcgaacct  agccttttg  1260
gaattgcct  ctacggcct  gcagccctg  ccgagtggt  cagtgcatt  cagagctgg  1320
catctttgg  gtctatgtc  ggcaggaaa  gacactcgt  atgaacaag  acgtggggc  1380
tctacttcg  accaaagcc  tcgagcatg  agatggtgg  gtggcagcg  gagtggcag  1440
cctggacaa  ccataccct  tgtgagggc  caaccaggc  acgggacct  ctatcctct  1500
tatttgtca  tcctctcct  gccctcctg  ggggtatcc  cctaaagac  tccaaagtt  1560
ttatggaag  gtaaatact  gtaccttcc  ccagctttc  atctgagga  cagaaaagt  1620
gtgtctccc  tagatgaga  ctagacgcc  ccaaatcct  gagatgtgg  tatagctca  1680
ggtaagctg  tctgaggta  aggtccatg  accctgccc  actcctgtc  gcccctcat  1740
agccttttc  gcaggttcc  gtgcctgac  tgggatagg  ctgagtggt  ggaggaggg  1800
gagtggagg  gcatagcct  tccctaatt  tgccttaaa  aaaactgca  tgctgt  1856



<210> 3238
<211> 474
<212> PRT
<213> Homo sapiens
<308> P48637
<400> 3238

Met Ala Thr Asn Trp Gly Ser Leu Leu Gln Asp Lys Gln Gln Leu Glu 
  1               5                  10                  15
Glu Leu Ala Arg Gln Ala Val Asp Arg Ala Leu Ala Glu Gly Val Leu 
             20                  25                  30
Leu Arg Thr Ser Gln Glu Pro Thr Ser Ser Glu Val Val Ser Tyr Ala 
         35                  40                  45
Pro Phe Thr Leu Phe Pro Ser Leu Val Pro Ser Ala Leu Leu Glu Gln 
     50                  55                  60
Ala Tyr Ala Val Gln Met Asp Phe Asn Leu Leu Val Asp Ala Val Ser 
 65                  70                  75                  80
Gln Asn Ala Ala Phe Leu Glu Gln Thr Leu Ser Ser Thr Ile Lys Gln 
                 85                  90                  95
Asp Asp Phe Thr Ala Arg Leu Phe Asp Ile His Lys Gln Val Leu Lys 
             100                105                110
Glu Gly Ile Ala Gln Thr Val Phe Leu Gly Leu Asn Arg Ser Asp Tyr 
         115                120                125
Met Phe Gln Arg Ser Ala Asp Gly Ser Pro Ala Leu Lys Gln Ile Glu 
     130                135                140
Ile Asn Thr Ile Ser Ala Ser Phe Gly Gly Leu Ala Ser Arg Thr Pro 
 145                150                155                160
Ala Val His Arg His Val Leu Ser Val Leu Ser Lys Thr Lys Glu Ala 
                 165                170                175
Gly Lys Ile Leu Ser Asn Asn Pro Ser Lys Gly Leu Ala Leu Gly Ile 
             180                185                190
Ala Lys Ala Trp Glu Leu Tyr Gly Ser Pro Asn Ala Leu Val Leu Leu 
         195                200                205
Ile Ala Gln Glu Lys Glu Arg Asn Ile Phe Asp Gln Arg Ala Ile Glu 
     210                215                220
Asn Glu Leu Leu Ala Arg Asn Ile His Val Ile Arg Arg Thr Phe Glu 
 225                230                235                240
Asp Ile Ser Glu Lys Gly Ser Leu Asp Gln Asp Arg Arg Leu Phe Val 
                 245                250                255
Asp Gly Gln Glu Ile Ala Val Val Tyr Phe Arg Asp Gly Tyr Met Pro 
             260                265                270
Arg Gln Tyr Ser Leu Gln Asn Trp Glu Ala Arg Leu Leu Leu Glu Arg 
         275                280                285
Ser His Ala Ala Lys Cys Pro Asp Ile Ala Thr Gln Leu Ala Gly Thr 
     290                295                300
Lys Lys Val Gln Gln Glu Leu Ser Arg Pro Gly Met Leu Glu Met Leu 
 305                310                315                320
Leu Pro Gly Gln Pro Glu Ala Val Ala Arg Leu Arg Ala Thr Phe Ala 
                 325                330                335
Gly Leu Tyr Ser Leu Asp Val Gly Glu Glu Gly Asp Gln Ala Ile Ala 
             340                345                350
Glu Ala Leu Ala Ala Pro Ser Arg Phe Val Leu Lys Pro Gln Arg Glu 
         355                360                365
Gly Gly Gly Asn Asn Leu Tyr Gly Glu Glu Met Val Gln Ala Leu Lys 
     370                375                380
Gln Leu Lys Asp Ser Glu Glu Arg Ala Ser Tyr Ile Leu Met Glu Lys 
 385                390                395                400
Ile Glu Pro Glu Pro Phe Glu Asn Cys Leu Leu Arg Pro Gly Ser Pro 
                 405                410                415
Ala Arg Val Val Gln Cys Ile Ser Glu Leu Gly Ile Phe Gly Val Tyr 
             420                425                430
Val Arg Gln Glu Lys Thr Leu Val Met Asn Lys His Val Gly His Leu 
         435                440                445
Leu Arg Thr Lys Ala Ile Glu His Ala Asp Gly Gly Val Ala Ala Gly 
     450                455                460
Val Ala Val Leu Asp Asn Pro Tyr Pro Val 
 465                470



<210> 3239
<211> 1882
<212> DNA
<213> Rattus norvegicus
<308> L38615
<400> 3239

tggagtttg  gcttggcga  cagctggac  acgagcgag  tgggatggc  accagctgg  60
gaagcatct  gcaggatga  aagcagctg  aagagttgg  acagcaggc  atagaccgg  120
ccctggctg  gggggtgtt  ctgaggtcc  caaagaacc  cagctcctc  gacgtggtg  180
cgtatgccc  attcacgct  ttcccctca  cagtgccca  cactctgct  gagcaggcc  240
atgctgtgc  gatggactt  aacatcctg  tagatgctg  cagccagaa  tccgccttc  300
tggagcaaa  actgtctag  accatcaaa  aggatgagt  tactgcccg  ctctttgat  360
tctacaagc  agtcctgaa  gagggcata  cccagactg  gttcctggg  ctcaatcgt  420
cagattaca  gttccagtg  agcgcagac  gctccaaag  cctgaaaca  attgagatc  480
acactatct  tgccagctt  gggggcctg  cctcccgga  tccggctgt  caccgacat  540
ttctcaatg  cctgaataa  accaacgaa  cttccaaga  cctgtccaa  aaccccagc  600
agggactgg  cctggggat  gccaaagcc  gggagctct  tggctcagc  aatgccgtg  660
tgctactga  tgctcagga  aaggaaagg  acatatttg  ccagcgtgc  atagagaac  720
agctgctag  caggaagat  catgtaatc  gccgaagat  tgaagatgt  tctgaaagg  780
gttctctag  ccaaaaccg  aggctgttt  tggaggacc  ggaagttgc  gtggtttac  840
tccgagatg  ctacatgcc  agtcagtat  acgcacaga  ctgggaagc  cgcctgctg  900
tagagagat  atgtgctgc  aagtgtccc  acattgcca  acagctggc  ggcactaag  960
aggtgcagc  ggaactgag  agggtgggc  tgctggaag  gctgctccc  ggccagccc  1020
aggctgtgg  ccgcctccg  gccaccttt  ctggcctct  ttcactgga  atgggtgaa  1080
aaggggacc  ggctgtcgc  gaggccctt  ctgccccta  ccactttgt  ctgaagccc  1140
aaagagagg  cggaggtaa  aacttctat  gggaggaaa  ggtacacgc  ctggagcag  1200
tgaaagaca  cgaggagag  gcctcctac  tcctcatgg  gaagattga  cctgagcct  1260
ttaggaatt  cttactacg  cctggcagc  ctgcccaag  ggtccagtg  atctcggag  1320
tgggtattt  tggagtcta  gtcagacag  gaacaacac  tgtgatgaa  aagcatgtg  1380
ggcatctgc  tcgaaccaa  gccattgaa  atgcagatg  aggtgtggc  gcaggagtg  1440
cagtcctgg  caaccccta  cctgtgtga  gacatgttc  gggcttcac  caagagacc  1500
tctatcctc  gtacttggc  ctcctctcc  gaggggcta  ccctgtacc  gtgttaggg  1560
agggagctt  tctctttca  agacctcca  gggctttag  gaagggaaa  tcccgggtc  1620
cttctctca  ccttccatc  aaggaccag  aaagctatg  ttccattgg  agagttctg  1680
agctcccca  atttggagt  ggaatggaa  ctcctttga  gcaaaggcc  acaaacccc  1740
cacatcttc  ttgccctct  gccagcctt  ccagcaggt  ctagtgcct  gacctgggg  1800
aggaccaag  gacaggagg  agagggtag  tgggcatag  cttccccag  tctgcccta  1860
ataaaacaa  gctgattca  tg  1882



<210> 3240
<211> 474
<212> PRT
<213> Rattus norvegicus
<308> P46413
<400> 3240

Met Ala Thr Ser Trp Gly Ser Ile Leu Gln Asp Glu Lys Gln Leu Glu 
  1               5                  10                  15
Glu Leu Ala Gln Gln Ala Ile Asp Arg Ala Leu Ala Glu Gly Val Leu 
             20                  25                  30
Leu Arg Ser Ala Lys Asn Pro Ser Ser Ser Asp Val Val Thr Tyr Ala 
         35                  40                  45
Pro Phe Thr Leu Phe Pro Ser Pro Val Pro Ser Thr Leu Leu Glu Gln 
     50                  55                  60
Ala Tyr Ala Val Gln Met Asp Phe Asn Ile Leu Val Asp Ala Val Ser 
 65                  70                  75                  80
Gln Asn Ser Ala Phe Leu Glu Gln Thr Leu Ser Ser Thr Ile Lys Lys 
                 85                  90                  95
Asp Glu Tyr Thr Ala Arg Leu Phe Asp Ile Tyr Lys Gln Val Leu Lys 
             100                105                110
Glu Gly Ile Ala Gln Thr Val Phe Leu Gly Leu Asn Arg Ser Asp Tyr 
         115                120                125
Met Phe Gln Cys Ser Ala Asp Gly Ser Lys Ala Leu Lys Gln Ile Glu 
     130                135                140
Ile Asn Thr Ile Ser Ala Ser Phe Gly Gly Leu Ala Ser Arg Thr Pro 
 145                150                155                160
Ala Val His Arg His Val Leu Asn Val Leu Asn Lys Thr Asn Glu Ala 
                 165                170                175
Ser Lys Ile Leu Ser Asn Asn Pro Ser Lys Gly Leu Ala Leu Gly Ile 
             180                185                190
Ala Lys Ala Trp Glu Leu Tyr Gly Ser Ala Asn Ala Val Val Leu Leu 
         195                200                205
Ile Ala Gln Glu Lys Glu Arg Asn Ile Phe Asp Gln Arg Ala Ile Glu 
     210                215                220
Asn Glu Leu Leu Asp Arg Lys Ile His Val Ile Arg Arg Arg Phe Glu 
 225                230                235                240
Asp Val Ser Glu Arg Gly Ser Leu Asp Gln Asn Arg Arg Leu Phe Met 
                 245                250                255
Glu Asp Gln Glu Val Ala Val Val Tyr Phe Arg Asp Gly Tyr Met Pro 
             260                265                270
Ser Gln Tyr Asn Ala Gln Asn Trp Glu Ala Arg Leu Leu Leu Glu Arg 
         275                280                285
Ser Cys Ala Ala Lys Cys Pro Asp Ile Ala Thr Gln Leu Ala Gly Thr 
     290                295                300
Lys Lys Val Gln Gln Glu Leu Ser Arg Val Gly Leu Leu Glu Ala Leu 
 305                310                315                320
Leu Pro Gly Gln Pro Glu Ala Val Ala Arg Leu Arg Ala Thr Phe Ala 
                 325                330                335
Gly Leu Tyr Ser Leu Asp Met Gly Glu Glu Gly Asp Gln Ala Val Ala 
             340                345                350
Glu Ala Leu Ala Ala Pro Ser His Phe Val Leu Lys Pro Gln Arg Glu 
         355                360                365
Gly Gly Gly Asn Asn Phe Tyr Gly Glu Glu Met Val His Ala Leu Glu 
     370                375                380
Gln Leu Lys Asp Ser Glu Glu Arg Ala Ser Tyr Ile Leu Met Glu Lys 
 385                390                395                400
Ile Glu Pro Glu Pro Phe Arg Asn Cys Leu Leu Arg Pro Gly Ser Pro 
                 405                410                415
Ala Gln Val Val Gln Cys Ile Ser Glu Leu Gly Ile Phe Gly Val Tyr 
             420                425                430
Val Arg Gln Gly Thr Thr Leu Val Met Asn Lys His Val Gly His Leu 
         435                440                445
Leu Arg Thr Lys Ala Ile Glu His Ala Asp Gly Gly Val Ala Ala Gly 
     450                455                460
Val Ala Val Leu Asp Asn Pro Tyr Pro Val 
 465                470



<210> 3241
<211> 1856
<212> DNA
<213> Homo sapiens
<308> NM_000178
<400> 3241

gggagaacc  ttcgcggag  aaaggcgaa  tagtgttgg  atggccacc  actggggga  60
cctcttgca  gataaacag  agctagagg  gctggcacg  caggccgtg  accgggccc  120
ggctgaggg  gtattgctg  ggacctcac  ggagcccac  tcctcggag  tggtgagct  180
tgccccatt  acgctcttc  cctcactgg  ccccagtgc  ctgctggag  aagcctatg  240
tgtgcagat  gacttcaac  tgctagtgg  tgctgtcag  cagaacgct  ccttcctgg  300
gcaaactct  tccagcacc  tcaaacagg  tgactttac  gctcgtctc  ttgacatcc  360
caagcaagt  ctaaaagag  gcattgccc  gactgtgtt  ctgggcctg  atcgctcag  420
ctacatgtt  cagcgcagc  cagatggct  cccagccct  aaacagatc  aaatcaaca  480
catctctgc  agctttggg  gcctggcct  ccggacccc  gctgtgcac  gacatgttc  540
cagtgtcct  agtaagacc  aagaagctg  caagatcct  tctaataat  ccagcaagg  600
actggccct  ggaattgcc  aagcctggg  gctctacgg  tcacccaat  ctctggtgc  660
actgattgc  caagagaag  aaagaaaca  atttgacca  cgtgccata  agaatgagc  720
actggccag  aacatccat  tgatccgac  aacatttga  gatatctct  aaaaggggt  780
tctggacca  gaccgaagg  tgtttgtgg  tggccagga  attgctgtg  tttacttcc  840
ggatggcta  atgcctcgt  agtacagtc  acagaattg  gaagcacgt  tactgctgg  900
gaggtcaca  gctgccaag  gcccagaca  tgccaccca  ctggctggg  ctaagaagg  960
gcagcagga  ctaagcagg  cgggcatgc  ggagatgtt  ctccctggc  agcctgagg  1020
tgtggcccg  ctccgcgcc  cctttgctg  cctctactc  ctggatgtg  gtgaagaag  1080
ggaccaggc  atcgccgag  cccttgctg  ccctagccg  tttgtgcta  agccccaga  1140
agagggtgg  ggtaacaac  tatatgggg  ggaaatggt  caggccctg  aacagctga  1200
ggacagtga  gagagggcc  cctacatcc  catggagaa  atcgaacct  agccttttg  1260
gaattgcct  ctacggcct  gcagccctg  ccgagtggt  cagtgcatt  cagagctgg  1320
catctttgg  gtctatgtc  ggcaggaaa  gacactcgt  atgaacaag  acgtggggc  1380
tctacttcg  accaaagcc  tcgagcatg  agatggtgg  gtggcagcg  gagtggcag  1440
cctggacaa  ccataccct  tgtgagggc  caaccaggc  acgggacct  ctatcctct  1500
tatttgtca  tcctctcct  gccctcctg  ggggtatcc  cctaaagac  tccaaagtt  1560
ttatggaag  gtaaatact  gtaccttcc  ccagctttc  atctgagga  cagaaaagt  1620
gtgtctccc  tagatgaga  ctagacgcc  ccaaatcct  gagatgtgg  tatagctca  1680
ggtaagctg  tctgaggta  aggtccatg  accctgccc  actcctgtc  gcccctcat  1740
agccttttc  gcaggttcc  gtgcctgac  tgggatagg  ctgagtggt  ggaggaggg  1800
gagtggagg  gcatagcct  tccctaatt  tgccttaaa  aaaactgca  tgctgt  1856



<210> 3242
<211> 474
<212> PRT
<213> Homo sapiens
<308> P48637
<400> 3242

Met Ala Thr Asn Trp Gly Ser Leu Leu Gln Asp Lys Gln Gln Leu Glu 
  1               5                  10                  15
Glu Leu Ala Arg Gln Ala Val Asp Arg Ala Leu Ala Glu Gly Val Leu 
             20                  25                  30
Leu Arg Thr Ser Gln Glu Pro Thr Ser Ser Glu Val Val Ser Tyr Ala 
         35                  40                  45
Pro Phe Thr Leu Phe Pro Ser Leu Val Pro Ser Ala Leu Leu Glu Gln 
     50                  55                  60
Ala Tyr Ala Val Gln Met Asp Phe Asn Leu Leu Val Asp Ala Val Ser 
 65                  70                  75                  80
Gln Asn Ala Ala Phe Leu Glu Gln Thr Leu Ser Ser Thr Ile Lys Gln 
                 85                  90                  95
Asp Asp Phe Thr Ala Arg Leu Phe Asp Ile His Lys Gln Val Leu Lys 
             100                105                110
Glu Gly Ile Ala Gln Thr Val Phe Leu Gly Leu Asn Arg Ser Asp Tyr 
         115                120                125
Met Phe Gln Arg Ser Ala Asp Gly Ser Pro Ala Leu Lys Gln Ile Glu 
     130                135                140
Ile Asn Thr Ile Ser Ala Ser Phe Gly Gly Leu Ala Ser Arg Thr Pro 
 145                150                155                160
Ala Val His Arg His Val Leu Ser Val Leu Ser Lys Thr Lys Glu Ala 
                 165                170                175
Gly Lys Ile Leu Ser Asn Asn Pro Ser Lys Gly Leu Ala Leu Gly Ile 
             180                185                190
Ala Lys Ala Trp Glu Leu Tyr Gly Ser Pro Asn Ala Leu Val Leu Leu 
         195                200                205
Ile Ala Gln Glu Lys Glu Arg Asn Ile Phe Asp Gln Arg Ala Ile Glu 
     210                215                220
Asn Glu Leu Leu Ala Arg Asn Ile His Val Ile Arg Arg Thr Phe Glu 
 225                230                235                240
Asp Ile Ser Glu Lys Gly Ser Leu Asp Gln Asp Arg Arg Leu Phe Val 
                 245                250                255
Asp Gly Gln Glu Ile Ala Val Val Tyr Phe Arg Asp Gly Tyr Met Pro 
             260                265                270
Arg Gln Tyr Ser Leu Gln Asn Trp Glu Ala Arg Leu Leu Leu Glu Arg 
         275                280                285
Ser His Ala Ala Lys Cys Pro Asp Ile Ala Thr Gln Leu Ala Gly Thr 
     290                295                300
Lys Lys Val Gln Gln Glu Leu Ser Arg Pro Gly Met Leu Glu Met Leu 
 305                310                315                320
Leu Pro Gly Gln Pro Glu Ala Val Ala Arg Leu Arg Ala Thr Phe Ala 
                 325                330                335
Gly Leu Tyr Ser Leu Asp Val Gly Glu Glu Gly Asp Gln Ala Ile Ala 
             340                345                350
Glu Ala Leu Ala Ala Pro Ser Arg Phe Val Leu Lys Pro Gln Arg Glu 
         355                360                365
Gly Gly Gly Asn Asn Leu Tyr Gly Glu Glu Met Val Gln Ala Leu Lys 
     370                375                380
Gln Leu Lys Asp Ser Glu Glu Arg Ala Ser Tyr Ile Leu Met Glu Lys 
 385                390                395                400
Ile Glu Pro Glu Pro Phe Glu Asn Cys Leu Leu Arg Pro Gly Ser Pro 
                 405                410                415
Ala Arg Val Val Gln Cys Ile Ser Glu Leu Gly Ile Phe Gly Val Tyr 
             420                425                430
Val Arg Gln Glu Lys Thr Leu Val Met Asn Lys His Val Gly His Leu 
         435                440                445
Leu Arg Thr Lys Ala Ile Glu His Ala Asp Gly Gly Val Ala Ala Gly 
     450                455                460
Val Ala Val Leu Asp Asn Pro Tyr Pro Val 
 465                470



<210> 3243
<211> 2991
<212> DNA
<213> Rattus norvegicus
<308> L38644
<400> 3243

tgcttccca  ccgaccccc  acccccatc  ccagttgga  ccgccgccc  agaggccgg  60
ccgtcgtct  gggaggagt  cccgccgcc  tcacctccg  catggagct  ataaccatc  120
tcgagaaga  cgtgtctcc  gatcggctg  agctggaag  ggcgcagaa  ttccttgag  180
gtgcggctg  ggagaatct  cccacgttc  tggtggaac  gtccagagt  ctggcaaat  240
ccggaaaca  tcaggttgc  agagttgca  ctggtctac  aattagact  ttgacatcg  300
aggatccag  tatcaaggc  cagtaccag  agaggtggc  tgctattga  gctaatgct  360
ggcgggaag  caagaacta  gttttgcag  ctttgggca  agagactta  cggcctagt  420
cagcctcac  gtgtgtggc  ggtatcgct  gtgcagaga  cccagtaag  cagtggccg  480
aactaattc  tcagctggt  gccaatgtc  ccaacccca  cagcacgga  cacatgaaa  540
agtccacac  ggaagccat  ggttacatt  gccaagata  agacccgga  cagctgcag  600
ataaatcca  tgagatcct  actgccata  tccagggca  gcggaagga  gagcctagt  660
acaatgtga  gctggccgc  accaacgcg  tcctgaact  actggagtt  accaaagca  720
acttcgaca  agagtctga  cggcacttt  tcatgcaag  ggtctgtga  gccacacag  780
gtccagata  aagggtaag  gtggctgct  tacagaatc  agtgaagat  atgtccttg  840
attaccagt  catggagac  tacatgggc  ctgccctct  tgcaatcac  attgaagca  900
tgaaaagtg  cattgatga  gtagctctc  aagggatag  gttctggtc  aatgtctgt  960
atgaggaaa  ggatttggc  attgaggct  cagaggcag  agaacaagg  cggcccccg  1020
agcacacca  caaatttta  gccaaggga  cgctgcagt  cctggtgcc  atcctcaca  1080
agacactaa  taaacagga  gaaaacgat  acgacgatg  ctggaaccc  tgcaaagca  1140
ctggggtgt  cctcatgct  ctgtctacc  gctgtgaag  tgacattgt  ccacatgtc  1200
ttcccttta  taaagagca  atcaagaac  ctgactggc  gtaccggga  gcagcagtg  1260
tggcttttg  cagcatctt  gaaggacca  agcctaacc  gcttaaacc  ttagtcata  1320
aggctatgc  caccctgat  gaattaatg  aagacccca  tgtagttgt  cgagataca  1380
cagcatgga  tgtgggcag  atctgtgag  tgctgcctg  agctgccat  aatgatgtc  1440
acttggcac  ccttttaca  tgtctgatt  agggtctca  tgctgaacc  agagtggct  1500
caaatgtgt  ctgggcttt  tccagtctg  ctgaagctg  ttacgaagc  gcagatgta  1560
ctgatgatc  ggaagaacc  gccacctat  gcttgtctt  ttcctttga  cttatagtt  1620
agaagctgc  ggagaccac  gacagacct  atggacacc  gaacaacct  agaagttct  1680
catatgaat  tctaatgga  attgtaaaa  acagtgcca  ggattgtta  cctgcggtg  1740
agaagacca  cctggtcat  atggaacgg  tgcagcagg  gcttcagat  gagtcccac  1800
tccagagca  gtcggacag  atccaattc  atgacctcc  gtctctact  tgtgcaact  1860
ttcagaatg  tctctggaa  gtgcagcat  aagatgctt  gcagatctc  gatgtggtc  1920
tggcctccc  gttaaggat  ttccaaagc  cagctgggt  tggcggagt  caagaagac  1980
ccctgatgg  agtcagcac  ctggtggaa  tgttgggtg  tgaattcct  aagtacatg  2040
aggccttta  accattcct  ggcattgga  tgaaaaatt  tgctgaatg  caggtgtgt  2100
tggcagctg  tggcttagt  ggagacttg  gccgagccc  gcagtctaa  atcttacct  2160
tctgtgatg  ggtgatgca  ctgctccta  agaacttag  gaatgagaa  gtccacagg  2220
ctgtgaaac  acagattct  tctgtgttt  gtgacatta  tcttgccat  ggtggagaa  2280
ttaagaaat  cttggaggt  gtactgaat  cactgcagc  ggcctccca  gcccaagtg  2340
acaagtcag  ctttgacat  gtggattat  tgaatgagc  aagagaaag  tgcttggaa  2400
cttatacgg  aatcgtcca  ggattgaag  gagaccagg  aaacgtaca  cctgatgta  2460
tgctggtgc  acccagagt  gaatttatt  tgtctttta  tgatcacat  gctggagat  2520
aggatcata  ggatggagt  gtagcttgt  ctgctggac  gatagggga  ttgtgtaca  2580
catttggaa  ggatgtact  aaattagta  aagctaggc  aatgatcca  gaactatta  2640
ctgaagggc  gagatcgaa  actaacaaa  caaagaccc  tgctacgtg  gcaacaaag  2700
aactgagga  actgaagaa  caagcttga  ctggtacca  tgggatgat  acctgagac  2760
cccactgga  atctccaat  ttttgaaag  acccggaag  gaggagtgt  cacggatgc  2820
gaatgtttg  gaatgagag  atgagtgag  gaggcttga  aacaccaca  tgaaaatcc  2880
gccacagcc  acagcagca  cgctgttag  gagctaagt  agcactgac  ttgtagaaa  2940
cacaacatc  gccatcttg  aacagagaa  caatggatt  acttactta  t  2991



<210> 3244
<211> 875
<212> PRT
<213> Rattus norvegicus
<308> P52296
<400> 3244

Met Glu Leu Ile Thr Ile Leu Glu Lys Thr Val Ser Pro Asp Arg Leu 
  1               5                  10                  15
Glu Leu Glu Ala Ala Gln Lys Phe Leu Glu Arg Ala Ala Val Glu Asn 
             20                  25                  30
Leu Pro Thr Phe Leu Val Glu Leu Ser Arg Val Leu Ala Asn Pro Gly 
         35                  40                  45
Asn Ser Gln Val Ala Arg Val Ala Ala Gly Leu Gln Ile Arg Leu Leu 
     50                  55                  60
Thr Ser Lys Asp Pro Asp Ile Lys Ala Gln Tyr Gln Gln Arg Trp Leu 
 65                  70                  75                  80
Ala Ile Asp Ala Asn Ala Arg Arg Glu Val Lys Asn Tyr Val Leu Gln 
                 85                  90                  95
Thr Leu Gly Thr Glu Thr Tyr Arg Pro Ser Ser Ala Ser Gln Cys Val 
             100                105                110
Ala Gly Ile Ala Cys Ala Glu Ile Pro Val Ser Gln Trp Pro Glu Leu 
         115                120                125
Ile Pro Gln Leu Val Ala Asn Val Thr Asn Pro Asn Ser Thr Glu His 
     130                135                140
Met Lys Glu Ser Thr Leu Glu Ala Ile Gly Tyr Ile Cys Gln Asp Ile 
 145                150                155                160
Asp Pro Glu Gln Leu Gln Asp Lys Ser Asn Glu Ile Leu Thr Ala Ile 
                 165                170                175
Ile Gln Gly Met Arg Lys Glu Glu Pro Ser Asn Asn Val Lys Leu Ala 
             180                185                190
Ala Thr Asn Ala Leu Leu Asn Ser Leu Glu Phe Thr Lys Ala Asn Phe 
         195                200                205
Asp Lys Glu Ser Glu Arg His Phe Ile Met Gln Val Val Cys Glu Ala 
     210                215                220
Thr Gln Cys Pro Asp Thr Arg Val Arg Val Ala Ala Leu Gln Asn Leu 
 225                230                235                240
Val Lys Ile Met Ser Leu Tyr Tyr Gln Tyr Met Glu Thr Tyr Met Gly 
                 245                250                255
Pro Ala Leu Phe Ala Ile Thr Ile Glu Ala Met Lys Ser Asp Ile Asp 
             260                265                270
Glu Val Ala Leu Gln Gly Ile Glu Phe Trp Ser Asn Val Cys Asp Glu 
         275                280                285
Glu Met Asp Leu Ala Ile Glu Ala Ser Glu Ala Ala Glu Gln Gly Arg 
     290                295                300
Pro Pro Glu His Thr Ser Lys Phe Tyr Ala Lys Gly Ala Leu Gln Tyr 
 305                310                315                320
Leu Val Pro Ile Leu Thr Gln Thr Leu Thr Lys Gln Asp Glu Asn Asp 
                 325                330                335
Asp Asp Asp Asp Trp Asn Pro Cys Lys Ala Ala Gly Val Cys Leu Met 
             340                345                350
Leu Leu Ser Thr Cys Cys Glu Asp Asp Ile Val Pro His Val Leu Pro 
         355                360                365
Phe Ile Lys Glu His Ile Lys Asn Pro Asp Trp Arg Tyr Arg Asp Ala 
     370                375                380
Ala Val Met Ala Phe Gly Ser Ile Leu Glu Gly Pro Glu Pro Asn Gln 
 385                390                395                400
Leu Lys Pro Leu Val Ile Gln Ala Met Pro Thr Leu Ile Glu Leu Met 
                 405                410                415
Lys Asp Pro Ser Val Val Val Arg Asp Thr Thr Ala Trp Thr Val Gly 
             420                425                430
Arg Ile Cys Glu Leu Leu Pro Glu Ala Ala Ile Asn Asp Val Tyr Leu 
         435                440                445
Ala Pro Leu Leu Gln Cys Leu Ile Glu Gly Leu Ser Ala Glu Pro Arg 
     450                455                460
Val Ala Ser Asn Val Cys Trp Ala Phe Ser Ser Leu Ala Glu Ala Ala 
 465                470                475                480
Tyr Glu Ala Ala Asp Val Ala Asp Asp Gln Glu Glu Pro Ala Thr Tyr 
                 485                490                495
Cys Leu Ser Ser Ser Phe Glu Leu Ile Val Gln Lys Leu Leu Glu Thr 
             500                505                510
Thr Asp Arg Pro Asp Gly His Gln Asn Asn Leu Arg Ser Ser Ala Tyr 
         515                520                525
Glu Ser Leu Met Glu Ile Val Lys Asn Ser Ala Lys Asp Cys Tyr Pro 
     530                535                540
Ala Val Gln Lys Thr Thr Leu Val Ile Met Glu Arg Leu Gln Gln Val 
 545                550                555                560
Leu Gln Met Glu Ser His Ile Gln Ser Thr Ser Asp Arg Ile Gln Phe 
                 565                570                575
Asn Asp Leu Gln Ser Leu Leu Cys Ala Thr Leu Gln Asn Val Leu Trp 
             580                585                590
Lys Val Gln His Gln Asp Ala Leu Gln Ile Ser Asp Val Val Met Ala 
         595                600                605
Ser Leu Leu Arg Met Phe Gln Ser Thr Ala Gly Ser Gly Gly Val Gln 
     610                615                620
Glu Asp Ala Leu Met Ala Val Ser Thr Leu Val Glu Val Leu Gly Gly 
 625                630                635                640
Glu Phe Leu Lys Tyr Met Glu Ala Phe Lys Pro Phe Leu Gly Ile Gly 
                 645                650                655
Leu Lys Asn Tyr Ala Glu Cys Gln Val Cys Leu Ala Ala Val Gly Leu 
             660                665                670
Val Gly Asp Leu Cys Arg Ala Leu Gln Ser Asn Ile Leu Pro Phe Cys 
         675                680                685
Asp Glu Val Met Gln Leu Leu Leu Glu Asn Leu Gly Asn Glu Asn Val 
     690                695                700
His Arg Ser Val Lys Pro Gln Ile Leu Ser Val Phe Gly Asp Ile Thr 
 705                710                715                720
Leu Ala Ile Gly Gly Glu Phe Lys Lys Tyr Leu Glu Val Val Leu Asn 
                 725                730                735
Thr Leu Gln Gln Ala Ser Gln Ala Gln Val Asp Lys Ser Asp Phe Asp 
             740                745                750
Met Val Asp Tyr Leu Asn Glu Leu Arg Glu Ser Cys Leu Glu Ala Tyr 
         755                760                765
Thr Gly Ile Val Gln Gly Leu Lys Gly Asp Gln Glu Asn Val His Pro 
     770                775                780
Asp Val Met Leu Val Gln Pro Arg Val Glu Phe Ile Leu Ser Phe Ile 
 785                790                795                800
Asp His Ile Ala Gly Asp Glu Asp His Thr Asp Gly Val Val Ala Cys 
                 805                810                815
Ala Ala Gly Leu Ile Gly Asp Leu Cys Thr Ala Phe Gly Lys Asp Val 
             820                825                830
Leu Lys Leu Val Glu Ala Arg Pro Met Ile His Glu Leu Leu Thr Glu 
         835                840                845
Gly Arg Arg Ser Lys Thr Asn Lys Ala Lys Thr Leu Ala Thr Trp Ala 
     850                855                860
Thr Lys Glu Leu Arg Lys Leu Lys Asn Gln Ala 
 865                870                875



<210> 3245
<211> 308
<212> DNA
<213> Homo sapiens
<308> AA738059
<400> 3245

tttgggatc  aatctcttt  ttgtcaggg  cccctccct  tggcccccc  ccaaaccta  60
aaaaaaaac  caagcctgg  agtgtcctg  ggaggggag  tagtatggg  aaacccctg  120
gctctaccc  ctggcctgg  cagtgcaga  agggagggc  catggggaa  gagtaggcc  180
gtaactcca  tgttttcaa  cctcactca  tcatcctct  attcccaaa  attcagcat  240
cgtgcacac  cctcacttc  aggtttttc  aaagatggg  gatttccag  gggggtcct  300
aggttatc  308



<210> 3246
<211> 6826
<212> DNA
<213> Rattus norvegicus
<308> L39018
<400> 3246

atgagaaga  cggcgcggc  gctcgcacc  ccaggccct  atagtttca  gcctttcac  60
cctgagtcg  tggcaaaca  cgagaggcg  attgccgag  gcaagctca  gaaaccacc  120
aaggcggat  gcagccacc  ggaggacga  gaagacagc  agcccaagc  aaacagtga  180
ctggaggct  ggaagagtt  gcctttcat  tacggggac  tcccgcaag  cctggttgc  240
gttcccctg  aggactttg  cccttacta  ttgacgcag  aaacctttg  agtattaaa  300
agagggaaa  ctctcttca  atttagtgc  acacctgcc  tgtacattt  aagcccttt  360
aacctgata  gaagaatag  tattaaaat  ttgatacac  cagttttca  catgatcat  420
atgtgcacc  tcctgacca  ctgtgtgtt  atgaccttt  gtaaccctc  agaatggtc  480
aagaatgtg  agtacacat  cacagggat  tacacattt  aatcactag  gaaaatcat  540
gcaagaggt  tctgcatag  cggcttcac  ttcttacga  acccgtgga  ctggttaga  600
ttcagtgtc  tcatgatgg  atatgtgac  gagtttgtg  acctgggca  tgtctcagc  660
ctgagaaca  tcagggttc  ccgagcttt  aaaactatc  ctgtaattc  aggcctgaa  720
acaatcgtg  gcgccctaa  ccagtccgt  aagaagctg  cggacgtga  gatcctgac  780
gtgttctgc  tgagtgttt  cgccctgat  ggcctgcag  tctttcatg  gaacctttc  840
aaacagtgt  tcgtgtggc  cataaactt  aacgagagc  acctggaga  cggcaccag  900
ggctttgac  gggaggaat  tatcaacaa  aaaacaaac  tttacatgg  tcctggcat  960
ctagaaccc  tgctctgcg  gaacagttc  gatgctggg  aatgcgaag  attccagtg  1020
agtaaagca  gaaggaacc  caactacgg  tacaccagc  ttgacacct  cagctgggc  1080
ttcttggca  tattccgcc  tatgaccca  gactattgg  agaacttat  ccagctgac  1140
ttacgagcc  ctgggaaaa  gtacatgat  ttctttgtc  tggtcatct  cgtgggttc  1200
ttctatccg  tgaacttga  cttggctgt  gtggccatg  cttatgagg  acagaacca  1260
gcaacactg  aggaggcag  gcaaaaaga  gccgagttc  aggcaatgc  ggagcaact  1320
aagaagcag  aggaggagg  acaggctgc  gcaatggcc  cctcagcgg  cactgtctc  1380
gaagacgcc  ttgaagaag  aggggaaga  ggggtaggc  ctccgagga  ctcttctga  1440
ctgtctaaa  tcagttcca  gagcgcgaa  gagcggcgg  accgacgga  gaagaggaa  1500
cagaaggag  tctctgaag  cgaggagaa  ggggacccg  agaaggtgt  taagtcaga  1560
tcggaatac  gtatgagaa  gaaggcctt  cggctgcca  acaacagga  agggaggaa  1620
ttttccatc  tgaatcagt  gctgctcag  attccaggc  cgcccttcc  ctcccgaca  1680
aacagcaaa  gcagcatct  cagcttcgg  gacccgtcg  ttcgggacc  cggctctga  1740
aatgagttc  cagacgatg  acacagcac  gtggaggag  gcgagggcc  gcgtgactc  1800
ctcttcatc  cgatccgcg  ccgcgagcg  cgcagcagc  acagtggct  cagcggcta  1860
agccagtgc  gccgctcgt  gcgcatctc  ccagcctgc  cgcagcgtg  agccaacag  1920
acggtggac  gcaacggcg  agtgtcact  atcgggccc  gctcacaca  cgggcggct  1980
ctgctgagg  aacgactga  gtggaaatt  agaagaaag  ccctggact  ttttagttt  2040
tatggacca  ctcgcctcc  acggacgga  ggacagaat  aacagcata  tgagcgtgg  2100
cacaaacac  ctagtgaag  gctggaaga  tctcagaga  agtgcccac  gtgctggta  2160
aagtttgcc  acactttcc  catctggga  tgtcacccc  actggataa  actgaagga  2220
atcgtgaac  taatcgtca  ggacccttt  gtagactta  ccatcacca  ctgcatcgt  2280
ctgaatacg  tatttatgg  aatggagca  catcccatg  caccacagt  cgaacacgt  2340
ttggccgta  gaaatctgg  gttcaccgg  atcttcacg  cggaaatgt  tctgaagct  2400
atagccatg  acccctact  ttatttcca  gaaggctgg  acatttttg  cggatttat  2460
gtctccctc  gtttaatgg  gctgagtct  gcagatgtg  aggggctct  agtgctgcg  2520
tctttccga  tgctccgag  cttcaagct  gccaagtcc  ggcccaccc  gaacatgct  2580
atcaagatc  tcgggaact  cgtgggtgc  ctgggcaac  tgaccctgg  gctggccat  2640
atcgtcttc  tcttcgccg  ggtggggat  cagctgttt  gaaagagtt  caaggagtg  2700
gtctgtaag  tcaaccagg  gtgcaagct  ccgcgctgg  acatgaacg  cttcttcca  2760
tccttcctc  tcgtcttcc  agtgctgtg  ggggagtgg  tcgagacca  gtgggactg  2820
atggaggtg  ccggccagg  catgtgcct  attgtcttc  tgatggtta  ggtcattgg  2880
aacctggtg  tgctgaatc  attcctggc  ttgcttctg  gctccttca  cgcagacaa  2940
ctggcggcc  cagacgacg  cggggaaat  aacaacctg  agatctcag  gatccggat  3000
aagaagggc  tggcctgga  caaagtgaa  gtgcacgcc  tcatgcagg  tcacttcaa  3060
cagcgggag  cggatgaag  gaaacccct  gacgagctg  atgagaaga  ggccaactg  3120
atcgccaac  acacgggcg  ggatatcca  cggaacggc  acttccaga  gaacgggaa  3180
ggaaccacc  gcggcatcg  cagcagcgt  gagaagtac  tcatcgacg  ggaccacat  3240
tccttcatt  acaacccaa  cctgaccgt  cgggtgccc  ttgctgtgg  cgagtctga  3300
ttcgagaac  tcaacacag  ggatgttag  agcgaatca  accctgaag  cagcaaaga  3360
aaactggac  ataccagct  ctcagaagg  agtaccatc  acatcaagc  tgaggtgga  3420
gaagttccc  tggagcaac  tgaggaata  ttggatccg  acgcctgct  tacagaggg  3480
tgcgtccag  ggttcaagt  ctgccaggt  aacatcgag  aaggactag  caagtcgtg  3540
tggatcttg  ggaaaacct  cttcctcat  gtggagcac  attggtttg  gaccttcat  3600
atcttcatg  ttctgctca  cagtggcgc  ctggccttt  aggacatct  cattgagca  3660
aggaagacc  tccgcacca  cctggagta  gcggacaag  tcttcacct  catcttcat  3720
ctggagatg  tgctcaagt  gaccacgta  ggcttcgtc  agttcttca  caatgcctg  3780
tgctggttg  acttcctca  tgtggctgt  tctttagtc  gccttatag  taatgccct  3840
ggctactcg  aactaggtg  cataaagtc  cttaggacc  taagagctt  gagaccctt  3900
agagcctta  cacgatttg  agggatgag  gtggtggtg  atgccttgg  gggtgccat  3960
ccctccatc  tgaatgtgc  gctggtgtg  ctcatcttc  ggctgattt  cagcatcat  4020
ggagttaac  tgtttgcgg  gaaatacca  tactgcttt  atgagactt  tgaaatccg  4080
ttcgaaatc  atattgtca  caataaaac  gactgtgag  agctcatgg  gggcaacag  4140
acggagatc  gatggaaga  tgtcaagat  aactttgac  atgtcggag  agggtacct  4200
gcccttctt  aagtggcaa  cttcaaagg  tggatggac  tcatgtatg  ggctgtaga  4260
tcccgaaag  cagacgagc  gcctgacta  gagggcaac  tctacatgt  catctactt  4320
gtcatcttc  tcatcttcg  ctccttctt  accctcaac  tgttcatcg  tgtcatcat  4380
gacaacttc  accagcaga  gaaaaagtt  ggaggtcag  acatcttca  gacagagga  4440
cagaagaag  actataatg  catgaaaaa  ctgggctcc  agaagccac  gaagcccat  4500
ccccgaccc  tgaacaaaa  ccaagggat  gtctttgat  tcgtcactc  acaagcctt  4560
gacattgtg  tcatgatgc  catctgcct  aacatggtg  caatgatgg  ggagacaga  4620
actcagagc  agcagatgg  gaacattct  tactggatt  atctggtct  tgtcatctt  4680
ttcacctgc  agtgtgtgc  caaaatgtt  gccttgaga  actactact  caccattgg  4740
tggaacatc  ttgactttg  ggtggtcat  ctctccatt  tgggaatgt  cctggctga  4800
atcattgag  agtacttcg  ctccccaac  ctattccga  ttatccgat  ggcccgtat  4860
gggcgcatc  tgcgtctga  caagggcgc  aaagggatc  gcactctgc  ctttgctct  4920
atgatgtcg  tgcccgccc  gttcaacat  ggcctcctg  tcttcctcg  catgttcat  4980
ttctccatt  ttggcatgt  caacttcgc  tacgtgaag  acgaggccg  cattgacga  5040
atgttcaac  tcgagacat  tggcaacag  atgatctgt  tgttccaga  cacaacgtc  5100
gctggctgg  atggcctgc  gctgccaat  ctgaaccgc  cccctgact  cagcttgga  5160
aaagagcac  cagggagtg  cttcaaagg  gactgtggg  acccctcgg  gggcatctt  5220
ttctttgtg  gctacatca  catctcctt  ctgattgtg  tgaacatgt  catcgccat  5280
atcctggag  acttcagcg  ggccaccga  gagagcgcc  accctctga  tgaggatga  5340
ttcgagact  tctatgaga  ctgggagaa  tttgaccca  acgccaccc  gttcatcga  5400
tactgtaag  tggcagact  tgccgacgc  ctggagcac  cgctccgag  acccaagcc  5460
aacaccatc  agctcatcg  catggacct  cccatggtg  gcggagatc  catccactg  5520
ttggacatc  ttttcgcct  caccaaggc  gtcctggga  acagtgggg  gttggacat  5580
ctgcggcag  agatggagg  gcggttcgt  gcatccaat  cttccaaag  gtcttacga  5640
gcctatcac  ccactctgc  gcgcaacga  gaggaggtg  ctgcagtgg  cctgcagcg  5700
gcctacagg  gacacttgg  taggcgggg  ttcatctgc  gaaagatgg  ctccaacaa  5760
ctggagaat  gaggcacac  cagagacaa  aaggagagc  ccccgtcca  agcctccct  5820
ccctcttac  acagcgtca  aaagccaga  aaggagaag  agcagcgtg  ggaggaggg  5880
agaagggaa  gagccaaga  gcaaaaaga  gtcagggag  ccaagtgct  gaggagggg  5940
aaggaagct  accccggct  aacactggc  agtgaaagc  tgtttacaa  cttccgaat  6000
tcacggatg  agacagctg  gcagacgct  gctgtactg  aagacctat  ccaaacata  6060
tctgcttac  tgtgacatg  tggcatcct  agcggtgac  gctgctggg  acaaaggac  6120
ctgctccct  gactcacag  tctcctatc  cttgggcag  cggttactg  atgttccac  6180
cttagtcaa  gcaacttag  actaaacta  ccaggatac  aaaccgagg  ggctggcga  6240
cagcagatc  ccgctgcag  caaatggat  ttatttttt  attttgttg  ttctcagaa  6300
cagaaagca  cactttaaa  gtttgtttg  tcatgcaaa  aatatttga  ttcttacat  6360
agttaagct  agcagcaaa  agaaacaca  acgcacaca  acacacaaa  acacacaca  6420
attcagcct  tgtcactaa  cgtctgttt  tttaacata  cagcatctt  tccacacga  6480
cggcacgtg  tttggagat  ggtggggga  aatcagggt  tcaggctga  gaggacttg  6540
tcaggccaa  cccaaatat  tgctcgttc  atgcataga  gtgacctgc  tgatggcat  6600
ctgtgttca  aagtcatgc  tgagaccca  acaccacaa  acactagta  tcctgtnnc  6660
atccacagg  tcagcctgc  gacaggacc  gccctgcac  gttcactgt  tttggagaa  6720
tggtaagag  tccacaccg  ctgcagtcc  ctcagtgta  gattctttc  tacacctct  6780
ggtagggag  cataattaa  caattgacc  ctaccaaca  aacaat  6826



<210> 3247
<211> 1976
<212> PRT
<213> Rattus norvegicus
<308> AAC42059
<400> 3247

Met Arg Arg Ser Ala Arg Leu Leu Ala Pro Pro Gly Pro Asp Ser Phe 
  1               5                  10                  15
Lys Pro Phe Thr Pro Glu Ser Leu Ala Asn Ile Glu Arg Arg Ile Ala 
             20                  25                  30
Glu Ser Lys Leu Lys Lys Pro Pro Lys Ala Asp Gly Ser His Arg Glu 
         35                  40                  45
Asp Asp Glu Asp Ser Lys Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly 
     50                  55                  60
Lys Ser Leu Pro Phe Ile Tyr Gly Asp Ile Pro Gln Gly Leu Val Ala 
 65                  70                  75                  80
Val Pro Leu Glu Asp Phe Asp Pro Tyr Tyr Leu Thr Gln Lys Thr Phe 
                 85                  90                  95
Val Val Leu Asn Arg Gly Lys Thr Leu Phe Arg Phe Ser Ala Thr Pro 
             100                105                110
Ala Leu Tyr Ile Leu Ser Pro Phe Asn Leu Ile Arg Arg Ile Ala Ile 
         115                120                125
Lys Ile Leu Ile His Ser Val Phe Ser Met Ile Ile Met Cys Thr Ile 
     130                135                140
Leu Thr Asn Cys Val Phe Met Thr Phe Ser Asn Pro Pro Glu Trp Ser 
 145                150                155                160
Lys Asn Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu 
                 165                170                175
Val Lys Ile Ile Ala Arg Gly Phe Cys Ile Asp Gly Phe Thr Phe Leu 
             180                185                190
Arg Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr 
         195                200                205
Val Thr Glu Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe 
     210                215                220
Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys 
 225                230                235                240
Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val 
                 245                250                255
Met Ile Leu Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu 
             260                265                270
Gln Leu Phe His Gly Asn Leu Ser Lys Gln Cys Val Val Trp Pro Ile 
         275                280                285
Asn Phe Asn Glu Ser Tyr Leu Glu Asn Gly Thr Arg Gly Phe Asp Trp 
     290                295                300
Glu Glu Tyr Ile Asn Asn Lys Thr Asn Phe Tyr Met Val Pro Gly Met 
 305                310                315                320
Leu Glu Pro Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Glu 
                 325                330                335
Gly Phe Gln Cys Ser Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr 
             340                345                350
Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe Arg Leu Met 
         355                360                365
Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala 
     370                375                380
Gly Lys Thr Tyr Met Ile Phe Phe Val Leu Val Ile Phe Val Gly Ser 
 385                390                395                400
Phe Tyr Pro Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu 
                 405                410                415
Glu Gln Asn Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu 
             420                425                430
Phe Lys Ala Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln 
         435                440                445
Ala Ala Ala Met Ala Thr Ser Ala Gly Thr Val Ser Glu Asp Ala Ile 
     450                455                460
Glu Glu Glu Gly Glu Asp Gly Val Gly Ser Pro Arg Ser Ser Ser Glu 
 465                470                475                480
Leu Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
                 485                490                495
Lys Lys Arg Lys Gln Lys Glu Leu Ser Glu Gly Glu Glu Lys Gly Asp 
             500                505                510
Pro Glu Lys Val Phe Lys Ser Glu Ser Glu Tyr Gly Met Arg Arg Lys 
         515                520                525
Ala Phe Arg Leu Pro Asp Asn Arg Ile Gly Arg Lys Phe Ser Ile Met 
     530                535                540
Asn Gln Ser Leu Leu Ser Ile Pro Gly Ser Pro Phe Leu Ser Arg His 
 545                550                555                560
Asn Ser Lys Ser Ser Ile Phe Ser Phe Gly Asp Pro Ser Val Arg Asp 
                 565                570                575
Pro Gly Ser Glu Asn Glu Phe Ala Asp Asp Glu His Ser Thr Val Glu 
             580                585                590
Glu Ser Glu Gly Arg Arg Asp Ser Leu Phe Ile Pro Ile Arg Ala Arg 
         595                600                605
Glu Arg Arg Ser Ser Tyr Ser Gly Tyr Ser Gly Tyr Ser Gln Cys Ser 
     610                615                620
Arg Ser Ser Arg Ile Ser Pro Ala Cys Ala Gln Arg Glu Ala Asn Ser 
 625                630                635                640
Thr Val Asp Cys Asn Gly Val Val Ser Leu Ile Gly Pro Gly Ser His 
                 645                650                655
Ile Gly Arg Leu Leu Leu Arg Gln Arg Leu Arg Trp Lys Leu Arg Arg 
             660                665                670
Lys Ala Leu Asp Ser Phe Ser Phe Tyr Gly Pro Thr Arg Leu Leu Arg 
         675                680                685
Thr Glu Gly Gln Asn Gln Gln His Asn Glu Arg Gly His Lys His Ala 
     690                695                700
Ser Glu Glu Leu Glu Glu Ser Gln Arg Lys Cys Pro Pro Cys Trp Tyr 
 705                710                715                720
Lys Phe Ala Asn Thr Phe Leu Ile Trp Glu Cys His Pro Tyr Trp Ile 
                 725                730                735
Lys Leu Lys Glu Ile Val Asn Leu Ile Val Met Asp Pro Phe Val Asp 
             740                745                750
Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
         755                760                765
Glu His His Pro Met Thr Pro Gln Phe Glu His Val Leu Ala Val Gly 
     770                775                780
Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe Leu Lys Leu 
 785                790                795                800
Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe 
                 805                810                815
Asp Gly Phe Ile Val Ser Leu Ser Leu Met Glu Leu Ser Leu Ala Asp 
             820                825                830
Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
         835                840                845
Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
     850                855                860
Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
 865                870                875                880
Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
                 885                890                895
Tyr Lys Glu Cys Val Cys Lys Ile Asn Gln Glu Cys Lys Leu Pro Arg 
             900                905                910
Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
         915                920                925
Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
     930                935                940
Gly Gln Ala Met Cys Leu Ile Val Phe Met Met Val Met Val Ile Gly 
 945                950                955                960
Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
                 965                970                975
Ser Ala Asp Asn Leu Ala Ala Thr Asp Asp Asp Gly Glu Met Asn Asn 
             980                985                990
Leu Gln Ile Ser Val Ile Arg Ile Lys Lys Gly Val Ala Trp Thr Lys 
         995                1000                1005
Val Lys Val His Ala Phe Met Gln Ala His Phe Lys Gln Arg Glu Ala 
     1010                1015                1020
Asp Glu Val Lys Pro Leu Asp Glu Leu Tyr Glu Lys Lys Ala Asn Cys 
 1025                1030                1035                1040
Ile Ala Asn His Thr Gly Val Asp Ile His Arg Asn Gly Asp Phe Gln 
                 1045                1050                1055
Lys Asn Gly Asn Gly Thr Thr Ser Gly Ile Gly Ser Ser Val Glu Lys 
             1060                1065                1070
Tyr Ile Ile Asp Glu Asp His Met Ser Phe Ile Asn Asn Pro Asn Leu 
         1075                1080                1085
Thr Val Arg Val Pro Ile Ala Val Gly Glu Ser Asp Phe Glu Asn Leu 
     1090                1095                1100
Asn Thr Glu Asp Val Ser Ser Glu Ser Asp Pro Glu Gly Ser Lys Asp 
 1105                1110                1115                1120
Lys Leu Asp Asp Thr Ser Ser Ser Glu Gly Ser Thr Ile Asp Ile Lys 
                 1125                1130                1135
Pro Glu Val Glu Glu Val Pro Val Glu Gln Pro Glu Glu Tyr Leu Asp 
             1140                1145                1150
Pro Asp Ala Cys Phe Thr Glu Gly Cys Val Gln Arg Phe Lys Cys Cys 
         1155                1160                1165
Gln Val Asn Ile Glu Glu Gly Leu Gly Lys Ser Trp Trp Ile Leu Arg 
     1170                1175                1180
Lys Thr Cys Phe Leu Ile Val Glu His Asn Trp Phe Glu Thr Phe Ile 
 1185                1190                1195                1200
Ile Phe Met Ile Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile 
                 1205                1210                1215
Tyr Ile Glu Gln Arg Lys Thr Ile Arg Thr Ile Leu Glu Tyr Ala Asp 
             1220                1225                1230
Lys Val Phe Thr Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Thr 
         1235                1240                1245
Thr Tyr Gly Phe Val Lys Phe Phe Thr Asn Ala Trp Cys Trp Leu Asp 
     1250                1255                1260
Phe Leu Ile Val Ala Val Ser Leu Val Ser Leu Ile Ala Asn Ala Leu 
 1265                1270                1275                1280
Gly Tyr Ser Glu Leu Gly Ala Ile Lys Ser Leu Arg Thr Leu Arg Ala 
                 1285                1290                1295
Leu Arg Pro Leu Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val 
             1300                1305                1310
Val Asn Ala Leu Val Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu 
         1315                1320                1325
Val Cys Leu Ile Phe Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu 
     1330                1335                1340
Phe Ala Gly Lys Tyr His Tyr Cys Phe Asn Glu Thr Ser Glu Ile Arg 
 1345                1350                1355                1360
Phe Glu Ile Asp Ile Val Asn Asn Lys Thr Asp Cys Glu Lys Leu Met 
                 1365                1370                1375
Glu Gly Asn Ser Thr Glu Ile Arg Trp Lys Asn Val Lys Ile Asn Phe 
             1380                1385                1390
Asp Asn Val Gly Ala Gly Tyr Leu Ala Leu Leu Gln Val Ala Thr Phe 
         1395                1400                1405
Lys Gly Trp Met Asp Ile Met Tyr Ala Ala Val Asp Ser Arg Lys Pro 
     1410                1415                1420
Asp Glu Gln Pro Asp Tyr Glu Gly Asn Ile Tyr Met Tyr Ile Tyr Phe 
 1425                1430                1435                1440
Val Ile Phe Ile Ile Phe Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile 
                 1445                1450                1455
Gly Val Ile Ile Asp Asn Phe Asn Gln Gln Lys Lys Lys Phe Gly Gly 
             1460                1465                1470
Gln Asp Ile Phe Met Thr Glu Glu Gln Lys Lys Tyr Tyr Asn Ala Met 
         1475                1480                1485
Lys Lys Leu Gly Ser Lys Lys Pro Gln Lys Pro Ile Pro Arg Pro Leu 
     1490                1495                1500
Asn Lys Ile Gln Gly Ile Val Phe Asp Phe Val Thr Gln Gln Ala Phe 
 1505                1510                1515                1520
Asp Ile Val Ile Met Met Leu Ile Cys Leu Asn Met Val Thr Met Met 
                 1525                1530                1535
Val Glu Thr Asp Thr Gln Ser Lys Gln Met Glu Asn Ile Leu Tyr Trp 
             1540                1545                1550
Ile Asn Leu Val Phe Val Ile Phe Phe Thr Cys Glu Cys Val Leu Lys 
         1555                1560                1565
Met Phe Ala Leu Arg His Tyr Tyr Phe Thr Ile Gly Trp Asn Ile Phe 
     1570                1575                1580
Asp Phe Val Val Val Ile Leu Ser Ile Val Gly Met Phe Leu Ala Asp 
 1585                1590                1595                1600
Ile Ile Glu Lys Tyr Phe Val Ser Pro Thr Leu Phe Arg Val Ile Arg 
                 1605                1610                1615
Leu Ala Arg Ile Gly Arg Ile Leu Arg Leu Ile Lys Gly Ala Lys Gly 
             1620                1625                1630
Ile Arg Thr Leu Leu Phe Ala Leu Met Met Ser Leu Pro Ala Leu Phe 
         1635                1640                1645
Asn Ile Gly Leu Leu Leu Phe Leu Val Met Phe Ile Phe Ser Ile Phe 
     1650                1655                1660
Gly Met Ser Asn Phe Ala Tyr Val Lys His Glu Ala Gly Ile Asp Asp 
 1665                1670                1675                1680
Met Phe Asn Phe Glu Thr Phe Gly Asn Ser Met Ile Cys Leu Phe Gln 
                 1685                1690                1695
Ile Thr Thr Ser Ala Gly Trp Asp Gly Leu Leu Leu Pro Ile Leu Asn 
             1700                1705                1710
Arg Pro Pro Asp Cys Ser Leu Asp Lys Glu His Pro Gly Ser Gly Phe 
         1715                1720                1725
Lys Gly Asp Cys Gly Asn Pro Ser Val Gly Ile Phe Phe Phe Val Ser 
     1730                1735                1740
Tyr Ile Ile Ile Ser Phe Leu Ile Val Val Asn Met Cys Ile Ala Ile 
 1745                1750                1755                1760
Ile Leu Glu Asn Phe Ser Val Ala Thr Glu Glu Ser Ala Asp Pro Leu 
                 1765                1770                1775
Ser Glu Asp Asp Phe Glu Thr Phe Tyr Glu Ile Trp Glu Lys Phe Asp 
             1780                1785                1790
Pro Asp Ala Thr Gln Phe Ile Glu Tyr Cys Lys Leu Ala Asp Phe Ala 
         1795                1800                1805
Asp Ala Leu Glu His Pro Leu Arg Val Pro Lys Pro Asn Thr Ile Glu 
     1810                1815                1820
Leu Ile Ala Met Asp Leu Pro Met Val Ser Gly Asp Arg Ile His Cys 
 1825                1830                1835                1840
Leu Asp Ile Leu Phe Ala Phe Thr Lys Ala Val Leu Gly Asp Ser Gly 
                 1845                1850                1855
Glu Leu Asp Ile Leu Arg Gln Gln Met Glu Glu Arg Phe Val Ala Ser 
             1860                1865                1870
Asn Pro Ser Lys Val Ser Tyr Glu Ala Tyr His Thr Thr Leu Arg Arg 
         1875                1880                1885
Asn Glu Glu Glu Val Ser Ala Val Val Leu Gln Arg Ala Tyr Arg Gly 
     1890                1895                1900
His Leu Ala Arg Arg Gly Phe Ile Cys Arg Lys Met Ala Ser Asn Lys 
 1905                1910                1915                1920
Leu Glu Asn Gly Gly Thr His Arg Asp Lys Lys Glu Ser Thr Pro Ser 
                 1925                1930                1935
Thr Ala Ser Leu Pro Ser Tyr Asp Ser Val Thr Lys Pro Asp Lys Glu 
             1940                1945                1950
Lys Gln Gln Arg Ala Glu Glu Gly Arg Arg Glu Arg Ala Lys Arg Gln 
         1955                1960                1965
Lys Glu Val Arg Glu Ser Lys Cys 
     1970                1975



<210> 3248
<211> 7008
<212> DNA
<213> Homo sapiens
<308> AB027567
<400> 3248

gagcgctcc  agatggcgc  caccgcagt  ccgcccgcc  catcctcgg  gcctttgca  60
tccggccgc  cctcccggg  cccgcgtta  ggccgccgc  gcctccctc  ccgccgccg  120
tgccagctg  cctgtcctg  acgcagcat  actaacgaa  ctgctgcag  atgagaaga  180
ggcagcgcg  ctgcttgca  caccaggcc  tgatagttt  aagcctttc  cccctgagt  240
actggcaaa  attgagagg  gcattgctg  gagcaagct  aagaaacca  caaaggccg  300
tggcagtca  cgggaggac  atgaggaca  caagcccaa  ccaaacagc  acctggaag  360
agggaagag  ttgcctttc  tctacgggg  catccccca  ggcctggtt  cagttcccc  420
ggaggactt  gacccatac  atttgacgc  gaaaacctt  gtagtatta  acagaggga  480
aactctctt  agatttagt  ccacgcctg  cttgtacat  ttaagtcct  ttaacctga  540
aagaagaat  gctattaaa  ttttgatac  ttcagtatt  agcatgatc  ttatgtgca  600
tattttgac  aactgtgta  tcatgactt  tagtaaccc  cctgactgg  cgaagaatg  660
ggagtacac  ttcacaggg  tttatacat  tgaatcact  gtgaaaatc  ttgcaagag  720
tttctgcat  gatggcttt  cctttttac  ggatccatg  aactggtta  atttcagtg  780
catcatgat  gcgtatata  cagagtttg  aaacctagg  aatgtttca  ctctacgca  840
tttcagggt  ctgagggct  tgaaaacta  ttcggtaat  ccaggcctg  agacaattg  900
gggtgccct  attcagtct  tgaagaaac  gtcagatgt  atgatcctg  cagtgttct  960
cctgagtgt  tttgccttg  tcggactgc  gctgttcat  gggaacctt  gaaacaagt  1020
tgttgtgtg  cccataaac  tcaacgaga  ctatcttga  aatggcacc  aaggctttg  1080
ttgggaaga  tatatcaac  ataaaacaa  tttctacac  gttcctggc  tgctggaac  1140
tttactctg  gggaacagt  ctgatgctg  gcaatgccc  gagggatac  agtgtatga  1200
agcaggaag  aaccccaac  atggttaca  aagttttga  acttttagc  gggccttct  1260
ggcattatt  cgccttatg  cccaggact  ttgggaaaa  ttgtatcaa  tgactttac  1320
agcagccgg  aaaacatac  tgatcttct  cgtcttggt  atctttgtg  gttctttct  1380
tctggtgaa  ttgatcttg  ctgtggtgg  catggctta  gaagaacag  atcaggcaa  1440
actggagga  gcagaacaa  aagaggctg  atttaaagc  atgttggag  aacttaaga  1500
gcaacagga  gaggcacag  ctgctgcga  ggccacttc  gcaggaact  tctcagaag  1560
tgccataga  gaagaaggt  aagaaggag  gggctcccc  cggagctct  ctgaaatct  1620
taaactcag  tcaaagagt  caaaggaaa  acgtaacag  agaaagaag  ggaagcaaa  1680
ggaactctc  gaaggagag  agaaagggg  tcccgagaa  gtgtttaag  cagagtcag  1740
agatggcat  agaaggaag  cctttcggc  gccagacaa  agaataggg  ggaaatttt  1800
catcatgaa  cagtcactg  tcagcatcc  aggctcgcc  ttcctctcc  gccacaaca  1860
caagagcag  atcttcagt  tcaggggac  tgggcggtt  cgagacccg  gctccgaga  1920
tgagttcgc  gatgacgag  acagcacgg  ggaggagag  gagggccgc  gggactccc  1980
cttcatccc  atccgggcc  gcgagcgcc  gagcagcta  agcggctac  gcggctaca  2040
ccagggcag  cgctcctcg  gcatcttcc  cagcctgcg  cgcagcgtg  agcgcaaca  2100
cacggtgga  tgcaacggc  tggtgtccc  catcggcgg  cccggctcc  acatcggcg  2160
gcgtctcct  ccagaggct  caactgagg  ggaaattaa  aagaaaggc  ctggatctc  2220
tttagtttc  atggaccaa  tagcctcct  cgggcggaa  gacagaatc  acagtataa  2280
gagtgttgt  acaaataca  tagtagaag  actggaaga  tctcagaga  agtgcccgc  2340
atgctggta  aaatttgcc  acactttcc  catctggga  tgccacccc  actggataa  2400
actgaaaga  attgtgaac  tgatagtta  ggacccttt  gtggattta  ccatcacca  2460
ctgcatcgt  ctgaataca  tgtttatgg  aatggagca  catcctatg  caccacaat  2520
tgaacatgt  ttggctgta  gaaatctgg  tttcactgg  attttcaca  cggaaatgt  2580
cctgaagct  atagccatg  atccctact  ttatttcca  gaaggttgg  acatttttg  2640
cggatttat  gtctccctc  gtttaatgg  actgagtct  gcagacgtg  aggggcttt  2700
agtgctgcg  tctttccga  tgctccgag  cttcaaatt  gccaaatcc  ggcccaccc  2760
gaacatgct  atcaagatt  ttggaaatt  agtgggtgc  ctgggcaac  tgacactgg  2820
gctggccat  attgtcttc  tctttgccg  ggtggggat  caactcttt  gaaaaagct  2880
caaagagtg  gtctgcaag  tcaaccagg  ctgtgaact  cctcgctgg  atatgcatg  2940
ctttttcca  tccttcctc  ttgtctttc  agtgttgtg  ggggagtgg  ttgagacca  3000
gtgggactg  atggaagtg  caggccagg  catgtgcct  attgtcttt  tgatggtca  3060
ggtgattgg  aacttggtg  tgctgaacc  gtttctggc  ttgctcctg  gctccttca  3120
tgcagacaa  ctggctgcc  cagatgacg  tggggaaat  aacaacctc  agatctcag  3180
gatccgtat  aagaagggt  tggcctgga  caaactaaa  gtgcacgcc  tcatgcagg  3240
ccactttaa  cagcgtgag  ctgatgagg  gaagcctct  gatgagttg  atgaaaaga  3300
ggccaactg  atcgccaat  acaccggtg  agacatcca  cggaatggt  acttccaga  3360
gaatggcaa  ggcacaacc  gcggcattg  cagcagcgt  gagaagtac  tcattgatg  3420
ggaccacat  tccttcatc  acaacccca  cttgactgt  cgggtaccc  ttgctgtgg  3480
cgagtctga  tttgagaac  tcaacacag  ggatgttag  agcgagtcg  atcctgaag  3540
cagcaaaga  aaactagat  acaccagct  ctctgaagg  agcaccatt  atatcaaac  3600
agaagtaga  gaggtccct  tggaacagc  tgaggaata  ttggatcca  atgcctgct  3660
cacagaagg  tgtgtccag  ggttcaagt  ctgccaggt  aacatcgag  aagggctag  3720
caagtcttg  tggatcctg  ggaaaacct  cttcctcat  gtggagcac  actggtttg  3780
gaccttcat  atcttcatg  ttctgctga  cagtggcgc  ctggccttc  aggacatct  3840
cattgagca  agaaagacc  tccgcacca  cctggaata  gctgacaaa  tcttcacct  3900
tatcttcat  ctggagatg  tgctcaagt  gacagccta  ggcttcgtc  agttcttca  3960
caatgcctg  tgttggctg  acttcctca  tgtggctgt  tctttagtc  gccttatag  4020
taatgccct  ggctactcg  aactaggtg  cataaagtc  cttaggacc  taagagctt  4080
gagaccctt  agagcctta  cacgatttg  agggatgag  gtggtggtg  atgccttgg  4140
gggcgccat  ccctccatc  tgaatgtgc  gctggtgtg  ctcatcttc  ggctgattt  4200
cagcatcat  ggagttaac  tgtttgcgg  aaagtacca  tactgcttt  atgagactt  4260
tgaaatccg  tttgaaatt  aagatgtca  caataaaac  gaatgtgaa  agcttatgg  4320
ggggaacaa  acagagatc  gatggaaga  cgtgaagat  aactttgac  atgttgggg  4380
aggatacct  gcccttctt  aagtagcaa  cttcaaagg  tggatggac  tcatgtatg  4440
agctgtaga  tcccggaag  ctgatgagc  gcctaagta  gaggacaat  tctacatgt  4500
catctattt  gtcatcttc  tcatcttcg  ctccttctt  accctgaac  tgttcattg  4560
tgtcatcat  gataacttc  atcaacaaa  gaaaaagtt  ggaggtcag  acatcttca  4620
gaccgaaga  cagaagaag  actacaatg  catgaaaaa  ctgggctca  agaagccac  4680
gaaacccat  ccccgcccc  tgaacaaaa  ccaaggaat  gtctttgat  ttgtcactc  4740
gcaagcctt  gacattgtt  tcatgatgc  catctgcct  aacatggtg  caatgatgg  4800
ggagacaga  actcaaagc  agcagatgg  gaacatcct  tactggatt  acctggtgt  4860
tgttatctt  ttcacctgt  agtgtgtgc  caaaatgtt  gcgttgagg  actactact  4920
caccattgg  tggaacatc  tcgacttcg  ggtagtcat  ctctccatt  tgggaatgt  4980
cctggcaga  ataattgag  aatactttg  ttccccaac  ctattccga  tcatccgat  5040
ggcccgtat  gggcgcatc  tgcgtctga  caaaggcgc  aaagggatt  gtaccctgc  5100
ctttgcctt  atgatgtcc  tgcctgccc  gttcaacat  ggccttctg  tcttcctgg  5160
catgttcat  ttctccatt  ttgggatgt  caattttgc  tatgtgaag  acgaggctg  5220
tatcgatga  atgttcaac  ttgagacat  tggcaacag  atgatctgc  tgtttcaaa  5280
cacaacctc  gctggttgg  atggcctgc  gctgcccat  ctaaaccgc  cccctgact  5340
cagcctaga  aaggaacac  cagggagtg  ctttaaggg  gattgtggg  acccctcag  5400
gggcatctt  ttctttgta  gctacatca  catctcttt  ctaattgtc  tgaacatgt  5460
cattgccat  atcctggag  acttcagtg  agccacaga  gaaagtgca  accctctga  5520
tgaggatga  tttgagacc  tctatgaga  ctgggagaa  ttcgacccc  atgccaccc  5580
gttcattga  tactgtaag  tggcagact  tgcagatgc  ttggagcat  ctctccgag  5640
gcccaagcc  aataccatt  agctcatcg  tatggatct  ccaatggtg  gcggggatc  5700
catccactg  ttggacatc  tttttgcct  caccaagcg  gtcctggga  atagcgggg  5760
gttggacat  ctgcggcag  agatggaag  gcggttcgt  gcatccaat  cttccaaag  5820
gtcttacga  ccaatcaca  ccacactgc  tcgcaagca  gaggaggta  ctgcagtgg  5880
cctgcagcg  gcctaccgg  gacatttgg  aaggcgggg  ttcatctgc  aaaagacaa  5940
ttctaataa  ctggagaat  gaggcacac  ccgggagaa  aaagagagc  ccccatcta  6000
agcctccct  ccgtcctat  acagtgtaa  taaacctga  aaggagaaa  agcagcggg  6060
agaggaagg  agaagggaa  gagccaaaa  acaaaaaga  gtcagagaa  ccaagtgtt  6120
gaggagaac  aaaattcag  attatacag  tctaaaact  gcaagtgaa  gattgttta  6180
aaacttcct  aatattatc  atgcagaac  gctgtggag  ctctaacct  aagatctat  6240
ccaaacgtc  tctgcttac  acgtaacac  gctgcatct  gagcagtga  ctgccaagg  6300
caaaggacc  cgctcccta  acttacaga  tttctaatg  ttgggcagg  ggttactgc  6360
tgttccaca  cagtcaatg  aacttagga  aaaactaac  agatacaga  acagaagag  6420
ggctgccgg  accagcata  ttccgttgc  gccaaatgg  ttttatttt  tcattttat  6480
gattctcag  agcagaaag  atcacttta  aagttcgtt  gttcatgca  actatattt  6540
cattcttac  ttagttaag  taagcagca  aaagaaaac  cacacacac  ctcacattt  6600
gcccatgtc  tttaattgt  agtttcttt  acataaagc  catcttctc  acatgggct  6660
cacgtggtt  ggagatggg  gggggaaaa  aatcaggtt  cttcaggct  aggaggact  6720
gctcaggcc  attccaaac  ttgtgctcg  tcaatgcgt  gaaatgatt  gcatgatgg  6780
atgccgtga  cagaagtca  gcatgagat  catacacca  aggacacta  taatctagt  6840
ccttgcact  ggtcagcct  tggacagga  ccagccctg  accgttcac  gtatttgga  6900
aaaatggta  gagttccat  ccgggctac  attctttga  ttcttaaaa  tccttcata  6960
accttctgg  tagggaaac  accaactaa  tgactaaca  caccaacg  7008



<210> 3249
<211> 1836
<212> PRT
<213> Homo sapiens
<308> XP_008249
<400> 3249

Met Ala Arg Pro Ser Leu Cys Thr Leu Val Pro Leu Gly Pro Glu Cys 
  1               5                  10                  15
Leu Arg Pro Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ala 
             20                  25                  30
Val Glu Glu Glu Ala Arg Leu Gln Arg Asn Lys Gln Met Glu Ile Glu 
         35                  40                  45
Glu Pro Glu Arg Lys Pro Arg Ser Asp Leu Glu Ala Gly Lys Asn Leu 
     50                  55                  60
Pro Met Ile Tyr Gly Asp Pro Pro Pro Glu Val Ile Gly Ile Pro Leu 
 65                  70                  75                  80
Glu Asp Leu Asp Pro Tyr Tyr Ser Asn Lys Lys Thr Phe Ile Val Leu 
                 85                  90                  95
Asn Lys Gly Lys Ala Ile Phe Arg Phe Ser Ala Thr Pro Ala Leu Tyr 
             100                105                110
Leu Leu Ser Pro Phe Ser Val Val Arg Arg Gly Ala Ile Lys Val Leu 
         115                120                125
Ile His Ala Leu Phe Ser Met Phe Ile Met Ile Thr Ile Leu Thr Asn 
     130                135                140
Cys Val Phe Met Thr Met Ser Asp Pro Pro Pro Trp Ser Lys Asn Val 
 145                150                155                160
Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile 
                 165                170                175
Leu Ala Arg Gly Phe Cys Val Asp Asp Phe Thr Phe Leu Arg Asp Pro 
             180                185                190
Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Leu Thr Glu 
         195                200                205
Phe Val Asp Leu Gly Asn Ile Ser Ala Leu Arg Thr Phe Arg Val Leu 
     210                215                220
Arg Ala Leu Lys Thr Ile Thr Val Ile Pro Gly Leu Lys Thr Ile Val 
 225                230                235                240
Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu 
                 245                250                255
Thr Val Phe Cys Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe 
             260                265                270
Met Gly Asn Leu Arg Gln Lys Cys Val Arg Trp Pro Pro Pro Phe Asn 
         275                280                285
Asp Thr Asn Thr Thr Trp Tyr Ser Asn Asp Thr Trp Tyr Gly Asn Asp 
     290                295                300
Thr Trp Tyr Gly Asn Glu Met Trp Tyr Gly Asn Asp Ser Trp Tyr Ala 
 305                310                315                320
Asn Asp Thr Trp Asn Ser His Ala Ser Trp Ala Thr Asn Asp Thr Phe 
                 325                330                335
Asp Trp Asp Ala Tyr Ile Ser Asp Glu Gly Asn Phe Tyr Phe Leu Glu 
             340                345                350
Gly Ser Asn Asp Ala Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly His 
         355                360                365
Cys Pro Glu Gly Tyr Glu Cys Ile Lys Thr Gly Arg Asn Pro Asn Tyr 
     370                375                380
Gly Tyr Thr Ser Tyr Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe 
 385                390                395                400
Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Phe Gln Leu Thr Leu 
                 405                410                415
Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Ile Ile Phe 
             420                425                430
Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val Ala Met 
         435                440                445
Ala Tyr Ala Glu Gln Asn Glu Ala Thr Leu Ala Glu Asp Lys Glu Lys 
     450                455                460
Glu Glu Glu Phe Gln Gln Met Leu Glu Lys Phe Lys Lys His Gln Glu 
 465                470                475                480
Glu Leu Glu Lys Ala Lys Ala Ala Gln Ala Leu Glu Gly Gly Glu Ala 
                 485                490                495
Asp Gly Asp Pro Ala His Gly Lys Asp Cys Asn Gly Ser Leu Asp Thr 
             500                505                510
Ser Gln Gly Glu Lys Gly Ala Pro Arg Gln Ser Gly Ser Gly Asp Ser 
         515                520                525
Gly Ile Ser Asp Ala Met Glu Glu Leu Glu Glu Ala His Gln Lys Cys 
     530                535                540
Pro Pro Trp Trp Tyr Lys Cys Ala His Lys Val Leu Ile Trp Asn Cys 
 545                550                555                560
Cys Ala Pro Trp Leu Lys Phe Lys Asn Ile Ile His Leu Ile Val Met 
                 565                570                575
Asp Pro Phe Val Asp Leu Gly Ile Thr Ile Cys Ile Val Leu Asn Thr 
             580                585                590
Leu Phe Met Ala Met Glu His Tyr Pro Met Thr Glu His Phe Asp Asn 
         595                600                605
Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu 
     610                615                620
Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Gln 
 625                630                635                640
Gly Trp Asn Ile Phe Asp Ser Ile Ile Val Thr Leu Ser Leu Val Glu 
                 645                650                655
Leu Gly Leu Ala Asn Val Gln Gly Leu Ser Val Leu Arg Ser Phe Arg 
             660                665                670
Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met 
         675                680                685
Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr 
     690                695                700
Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln 
 705                710                715                720
Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Ala Leu Asp 
                 725                730                735
Cys Asn Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu 
             740                745                750
Ile Val Phe Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp 
         755                760                765
Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Leu Met 
     770                775                780
Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu 
 785                790                795                800
Leu Leu Ser Ser Phe Ser Ala Asp Ser Leu Ala Ala Ser Asp Glu Asp 
                 805                810                815
Gly Glu Met Asn Asn Leu Gln Ile Ala Ile Gly Arg Ile Lys Leu Gly 
             820                825                830
Ile Gly Phe Ala Lys Ala Phe Leu Leu Gly Leu Leu His Gly Lys Ile 
         835                840                845
Leu Ser Pro Lys Asp Ile Met Leu Ser Leu Gly Glu Ala Asp Gly Ala 
     850                855                860
Gly Glu Ala Gly Glu Ala Gly Glu Thr Ala Pro Glu Asp Glu Lys Lys 
 865                870                875                880
Glu Pro Pro Glu Glu Asp Leu Lys Lys Asp Asn His Ile Leu Asn His 
                 885                890                895
Met Gly Leu Ala Asp Gly Pro Pro Ser Ser Leu Glu Leu Asp His Leu 
             900                905                910
Asn Phe Ile Asn Asn Pro Tyr Leu Thr Ile Gln Val Pro Ile Ala Ser 
         915                920                925
Glu Glu Ser Asp Leu Glu Met Pro Thr Glu Glu Glu Thr Asp Thr Phe 
     930                935                940
Ser Glu Pro Glu Asp Ser Lys Lys Pro Pro Gln Pro Leu Tyr Asp Gly 
 945                950                955                960
Asn Ser Ser Val Cys Ser Thr Ala Asp Tyr Lys Pro Pro Glu Glu Asp 
                 965                970                975
Pro Glu Glu Gln Ala Glu Glu Asn Pro Glu Gly Glu Gln Pro Glu Glu 
             980                985                990
Cys Phe Thr Glu Ala Cys Val Gln Arg Trp Pro Cys Leu Tyr Val Asp 
         995                1000                1005
Ile Ser Gln Gly Arg Gly Lys Lys Trp Trp Thr Leu Arg Arg Ala Cys 
     1010                1015                1020
Phe Lys Ile Val Glu His Asn Trp Phe Glu Thr Phe Ile Val Phe Met 
 1025                1030                1035                1040
Ile Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu 
                 1045                1050                1055
Gln Arg Arg Val Ile Arg Thr Ile Leu Glu Tyr Ala Asp Lys Val Phe 
             1060                1065                1070
Thr Tyr Ile Phe Ile Met Glu Met Leu Leu Lys Trp Val Ala Tyr Gly 
         1075                1080                1085
Phe Lys Val Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile 
     1090                1095                1100
Val Asp Val Ser Ile Ile Ser Leu Val Ala Asn Trp Leu Gly Tyr Ser 
 1105                1110                1115                1120
Glu Leu Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro 
                 1125                1130                1135
Leu Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala 
             1140                1145                1150
Leu Leu Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu 
         1155                1160                1165
Ile Phe Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly 
     1170                1175                1180
Lys Phe Tyr Tyr Cys Ile Asn Thr Thr Thr Ser Glu Arg Phe Asp Ile 
 1185                1190                1195                1200
Ser Glu Val Asn Asn Lys Ser Glu Cys Glu Ser Leu Met His Thr Gly 
                 1205                1210                1215
Gln Val Arg Trp Leu Asn Val Lys Val Asn Tyr Asp Asn Val Gly Leu 
             1220                1225                1230
Gly Tyr Leu Ser Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp 
         1235                1240                1245
Ile Met Tyr Ala Ala Val Asp Ser Arg Glu Lys Glu Glu Gln Pro Gln 
     1250                1255                1260
Tyr Glu Val Asn Leu Tyr Met Tyr Leu Tyr Phe Val Ile Phe Ile Ile 
 1265                1270                1275                1280
Phe Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp 
                 1285                1290                1295
Asn Phe Asn Gln Gln Lys Lys Lys Leu Gly Gly Lys Asp Ile Phe Met 
             1300                1305                1310
Thr Glu Glu Gln Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser 
         1315                1320                1325
Lys Lys Pro Gln Lys Pro Ile Pro Arg Pro Gln Asn Lys Ile Gln Gly 
     1330                1335                1340
Met Val Tyr Asp Leu Val Thr Lys Gln Ala Phe Asp Ile Thr Ile Met 
 1345                1350                1355                1360
Ile Leu Ile Cys Leu Asn Met Val Thr Met Met Val Glu Thr Asp Asn 
                 1365                1370                1375
Gln Ser Gln Leu Lys Val Asp Ile Leu Tyr Asn Ile Asn Met Ile Phe 
             1380                1385                1390
Ile Ile Ile Phe Thr Gly Glu Cys Val Leu Lys Met Leu Ala Leu Arg 
         1395                1400                1405
Gln Tyr Tyr Phe Thr Val Gly Trp Asn Ile Phe Asp Phe Val Val Val 
     1410                1415                1420
Ile Leu Ser Ile Val Gly Leu Ala Leu Ser Asp Leu Ile Gln Lys Tyr 
 1425                1430                1435                1440
Phe Val Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly 
                 1445                1450                1455
Arg Val Leu Arg Leu Ile Arg Gly Ala Lys Gly Ile Arg Thr Leu Leu 
             1460                1465                1470
Phe Ala Leu Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu 
         1475                1480                1485
Leu Phe Leu Val Met Phe Ile Tyr Ser Ile Phe Gly Met Ser Asn Phe 
     1490                1495                1500
Ala Tyr Val Lys Lys Glu Ser Gly Ile Asp Asp Met Phe Asn Phe Glu 
 1505                1510                1515                1520
Thr Phe Gly Asn Ser Ile Ile Cys Leu Phe Glu Ile Thr Thr Ser Ala 
                 1525                1530                1535
Gly Trp Asp Gly Leu Leu Asn Pro Ile Leu Asn Ser Gly Pro Pro Asp 
             1540                1545                1550
Cys Asp Pro Asn Leu Glu Asn Pro Gly Thr Ser Val Lys Gly Asp Cys 
         1555                1560                1565
Gly Asn Pro Ser Ile Gly Ile Cys Phe Phe Cys Ser Tyr Ile Ile Ile 
     1570                1575                1580
Ser Phe Leu Ile Val Val Asn Met Tyr Ile Ala Ile Ile Leu Glu Asn 
 1585                1590                1595                1600
Phe Asn Val Ala Thr Glu Glu Ser Ser Glu Pro Leu Gly Glu Asp Asp 
                 1605                1610                1615
Phe Glu Met Phe Tyr Glu Thr Trp Glu Lys Phe Asp Pro Asp Ala Thr 
             1620                1625                1630
Gln Phe Ile Ala Tyr Ser Arg Leu Ser Asp Phe Val Asp Thr Leu Gln 
         1635                1640                1645
Glu Pro Leu Arg Ile Ala Lys Pro Asn Lys Ile Lys Leu Ile Thr Leu 
     1650                1655                1660
Asp Leu Pro Met Val Pro Gly Asp Lys Ile His Cys Leu Asp Ile Leu 
 1665                1670                1675                1680
Phe Ala Leu Thr Lys Glu Val Leu Gly Asp Ser Gly Glu Met Asp Ala 
                 1685                1690                1695
Leu Lys Gln Thr Met Glu Glu Lys Phe Met Ala Ala Asn Pro Ser Lys 
             1700                1705                1710
Val Ser Tyr Glu Pro Ile Thr Thr Thr Leu Lys Arg Lys His Glu Glu 
         1715                1720                1725
Val Cys Ala Ile Lys Ile Gln Arg Ala Tyr Arg Arg His Leu Leu Gln 
     1730                1735                1740
Arg Ser Met Lys Gln Ala Ser Tyr Met Tyr Arg His Ser His Asp Gly 
 1745                1750                1755                1760
Ser Gly Asp Asp Ala Pro Glu Lys Glu Gly Leu Leu Ala Asn Thr Met 
                 1765                1770                1775
Ser Lys Met Tyr Gly His Glu Asn Gly Asn Ser Ser Ser Pro Ser Pro 
             1780                1785                1790
Glu Glu Lys Gly Glu Ala Gly Asp Ala Gly Pro Thr Met Gly Leu Met 
         1795                1800                1805
Pro Ile Ser Pro Ser Asp Thr Ala Trp Pro Pro Ala Pro Pro Pro Gly 
     1810                1815                1820
Gln Thr Val Arg Pro Gly Val Lys Glu Ser Leu Val 
 1825                1830                1835



<210> 3250
<211> 413
<212> DNA
<213> Rattus norvegicus
<308> L48209
<400> 3250

gctgaggag  ctgaccggc  cggcccggc  gcttatggt  ccgcgggct  aggtccact  60
gaagccgcc  cgggagcag  tcggggtcc  ggatatcac  attgggctc  cttcctgct  120
cgtgtgttg  cttctacct  cgggctggg  cctgtcaca  ctggaaagc  acaagaagc  180
ggagtgaag  gagcgtctt  cctcatcct  tgactagac  actcttgcc  gcccacctt  240
atcatgttt  ctgcattcc  ggctggctt  ccctgggat  atgttattc  attccagtc  300
cctcttctg  aatcatgac  tctcgatgt  tccatggtg  caactggga  cacatatat  360
ggttctgct  gatggggtc  ccctttgta  caataaagt  tatttaaac  ttg  413



<210> 3251
<211> 44
<212> PRT
<213> Rattus norvegicus
<308> P80433
<400> 3251

Val His Ser Lys Pro Pro Arg Glu Gln Leu Gly Val Leu Asp Ile Thr 
  1               5                  10                  15
Ile Gly Leu Thr Ser Cys Phe Val Cys Cys Leu Leu Pro Ala Gly Trp 
             20                  25                  30
Val Leu Ser His Leu Glu Ser Tyr Lys Lys Arg Glu 
         35                  40



<210> 3252
<211> 628
<212> DNA
<213> Rattus norvegicus
<308> M10094
<400> 3252

gagctactg  gcccagatc  cccaaaggc  catgtgacc  ttcacccca  acctgaagg  60
gatgtcacc  tgaggtgct  ggccctggg  ttctaccct  ctgacatca  cctgacctg  120
cagttgaat  gggaggacc  gacccagga  atggagctt  tggagacca  gcctgcagg  180
gatggaacc  tccagaagt  ggaagctgt  gtggtgcct  ttgggaagg  acagaatta  240
acatgcctt  tggagcatg  ggggctgcc  gagccgctt  ccctgagat  gagtaagga  300
ggagccttc  atagaccct  agctggtca  ggctgagag  tggggtcat  aaatgaaat  360
aaatggttc  ctggggcaa  ttaatctgt  gctcagttc  caagaacca  caatggctg  420
tcagttcag  agaaacaag  aggctgagc  gtttgctgt  tagtagttc  tgggggcaa  480
tccaatctc  aattgacag  acagcagca  tccaggtca  tagtgtcag  atagcaaac  540
ggaatcatc  gcggtggca  aaaccagca  aaactgcca  gcatccacc  aatcagcat  600
agtcagcag  actgagcag  gaagcctg  628



<210> 3253
<211> 319
<212> PRT
<213> Rattus norvegicus
<308> P15978
<400> 3253

Met Gly Ala Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Val 
  1               5                  10                  15
Leu Ala Pro Thr Gln Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe 
             20                  25                  30
His Thr Ala Val Ser Arg Pro Gly Leu Gly Glu Pro Arg Phe Ile Ser 
         35                  40                  45
Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Tyr Asp Ser Asp Ala 
     50                  55                  60
Glu Asn Pro Arg Tyr Glu Pro Arg Ala Arg Trp Met Glu Arg Glu Gly 
 65                  70                  75                  80
Pro Glu Tyr Trp Glu Glu Gln Thr Leu Val Ala Lys Gly Gln Glu Leu 
                 85                  90                  95
Asp Tyr Arg Val Ser Leu Arg Asn Leu Leu Ser Tyr Tyr Asn Gln Ser 
             100                105                110
Glu Gly Gly Ser His Thr Ile Gln Arg Met Tyr Gly Cys Asp Val Gly 
         115                120                125
Ser Asp Gly Ser Leu Leu Arg Gly Tyr Glu Gln His Ala Tyr Asp Gly 
     130                135                140
Arg Asp Tyr Ile Ala Leu Asn Glu Asp Leu Lys Thr Trp Ala Val Ala 
 145                150                155                160
Asp Phe Ala Ala Trp Ile Thr Arg Ser Lys Trp Gln Arg Asn Gly Ala 
                 165                170                175
Ala Glu Arg Ser Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
             180                185                190
Leu Arg Tyr Leu Glu Arg Gly Lys Glu Thr Leu Leu Arg Ser Asp Pro 
         195                200                205
Pro Glu Ala His Val Thr Leu His Pro Arg Pro Glu Gly Asp Val Thr 
     210                215                220
Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr 
 225                230                235                240
Trp Gln Leu Asn Gly Glu Asp Leu Thr Gln Asp Met Glu Leu Val Glu 
                 245                250                255
Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val 
             260                265                270
Val Pro Leu Gly Lys Glu Gln Asn Tyr Thr Cys Arg Val Glu His Glu 
         275                280                285
Gly Leu Pro Glu Pro Leu Ser Gln Arg Trp Glu Pro Ser Pro Ser Thr 
     290                295                300
Asp Ser Asn Leu Leu Leu Leu Phe Leu Glu Leu Trp Gln Phe Leu 
 305                310                315



<210> 3254
<211> 2959
<212> DNA
<213> Homo sapiens
<308> I38874
<400> 3254

ggatccggt  tatgccgca  caggcatga  cagcccgaa  atgcgcctg  tggctgcaa  60
gaccgagga  atgacccgc  ttttcggcg  tgaccaggc  ttttcacat  ggctgagcc  120
gtggccact  cacgtctcc  acgatccca  cgcgtaccg  tggcatgcc  agcacaatc  180
cgtggatcg  ctagctgat  ccgaaaaag  ttttgcctt  tgtaaaaaa  ttctcggtc  240
ccccgcaaa  tttcgattc  agatttttt  aaaaccaag  cagaaatac  acacaccgt  300
tgcagataa  ctgtctttc  gaaaaatca  gtgcgatac  aaattttta  cacccctga  360
gtgcgcaaa  tcccgcttc  tgaaaattt  cgtgccgcg  gattttccg  caaaaactt  420
aacgaacgt  cgttataat  gtgtcatga  cttcacgac  aagtaccaa  attggcccg  480
atcatcagc  atggatctc  ctgatgtcg  gctggagtc  gacgcgctc  atgctgccg  540
cgatttaaa  acggtgatc  gatttttcc  agctctcga  acgacggac  cgccagcat  600
acgagactg  gccagtgcc  cgagcgacc  agaaactct  gtggcggat  ttgaggagc  660
ggctgacga  ctgcgtgct  ggcagcgcc  ggaggacgc  cagtagtgg  ggatcgaat  720
agttgcgcc  actgcggtg  cctgattcc  ccccggcct  acccgcgag  acggcgcgc  780
aaatattgc  cagatgcgt  tcgtgccgc  gccagccgc  agcgcgcca  caaacgcca  840
gccgaggag  tggaggcgg  taggtcgca  atggcgctg  aagtgcgtc  cccgagcga  900
attttggcc  tggtcgtca  agagctgga  gcggcagcg  gaattatcc  cgatcgtgg  960
gcggtgccc  caggcatga  aaacatcgt  aatgccgcg  ttcgtgtgg  cgtggccgc  1020
caggacgtg  cagcgccgc  accacctgc  ccgaatcgg  agcagcgtc  cgcgtcgaa  1080
aagcgcaca  gcggcaaga  gcgataagc  gcacgaata  ctgaaaaat  ttgaacgcc  1140
cgtgagcgg  aactcacag  gcgtcggct  acccccagt  caaacctgg  agaaagcgc  1200
caaaaatga  tctagcgga  tcacgagac  ttgacacac  ggcctggaa  ttttccgct  1260
atctgttcg  cacccatcc  gagctcgcg  tgcgatcac  tggctggac  agcgaagac  1320
gccgcgaat  cctcgctca  ctgggcaga  aaaatttcc  gggcagcaa  acccgcgac  1380
tcgccagcg  ttggatcaa  gacccggac  cgggagaaa  acagccgaa  ttataccga  1440
ttggttcaa  atcgcttgc  cggtgccag  atgttgctc  gacgcacgc  cagcacgca  1500
ccgtgcttg  cctggacat  gatgtgccg  gccaccagg  cggcgggaa  atcgagcac  1560
taaaccccg  ggtctacgc  attttggag  gctgggcac  cctggaaaa  gcgccagct  1620
ggatcggcg  gaatccact  agcgggaaa  gccagctca  ctggctcat  gatccggtg  1680
atgccgcag  aggcatgag  agcccgaat  tgcgcctgc  ggctgcaac  accgaggaa  1740
tgacccgcg  tttcggcgc  gaccaggct  tttcacata  gctgagccg  tggccactg  1800
acgtctccg  cgatcccac  gcgtaccgc  ggcatgccc  gcacaatcg  gtggatcgc  1860
tagctgatc  tatggaggt  gctcgcatg  tctcaggca  agaaaaacc  aaaaaacgc  1920
atgagcagg  gttttctag  ggacgggca  gtatcgaag  ggcaagaaa  gccactgcg  1980
aagcaaaag  acttgccac  cttgaagca  gcctgccga  cgccgctga  gcgtctgga  2040
agctgatcg  cggcgtccg  gtcctctgg  ctgctccag  gcgtgccgc  cgtgatgag  2100
cggcttttc  ccacgcttt  actgtggga  accagttaa  agcggctgg  gagcgccta  2160
aagacacca  gatcatcga  gcctacgag  gtgcctaca  cgtcgctca  gcggtcgga  2220
cagacggcc  tgagcctga  ctgccgccg  tgcgtgacc  ccagacgat  gcgcgacgt  2280
tgcgcggct  cgtcgctaa  ggccagcca  tcgtccctg  tcgtcagac  gagacgcag  2340
gcagccgag  gcgaaaagc  ctggccact  tgggaagac  tggcggtaa  aaggccgca  2400
aacgctgga  agacccaaa  agtgagtac  cccgagcac  gcgagaaaa  ctagctaag  2460
ccagtcaac  acaagctag  aaagctaaa  gaaatcgct  gaccattgc  ggttggttt  2520
tgactgttg  gggagagac  ggctcgtgg  cgacaatca  tgaagctat  tctgaattt  2580
gcgtgtcac  tcagaccgt  aatagagca  ttaagtctg  gggcattga  cttccacga  2640
gacgccgta  agcttccca  taaatgtgc  atctcgtag  cagaaaacg  ttccccccg  2700
aggggtctc  ctcttggcc  cctttctag  tcgggctga  tgctcttga  gctctctag  2760
ggggctcac  ccataggca  ataacggtt  cccaccggc  cacctcgta  gcgcacaag  2820
actgctccc  aagatcgcc  agctgatct  atggaggtt  ctcgcatga  cctttttga  2880
aatctcatg  ccaaaatcc  ttaacgtga  ttttcgttc  actgagcgt  agaccccgt  2940
gaaaagatc  ccgggtacc  2959



<210> 3255
<211> 628
<212> DNA
<213> Rattus norvegicus
<308> M10094
<400> 3255

gagctactg  gcccagatc  cccaaaggc  catgtgacc  ttcacccca  acctgaagg  60
gatgtcacc  tgaggtgct  ggccctggg  ttctaccct  ctgacatca  cctgacctg  120
cagttgaat  gggaggacc  gacccagga  atggagctt  tggagacca  gcctgcagg  180
gatggaacc  tccagaagt  ggaagctgt  gtggtgcct  ttgggaagg  acagaatta  240
acatgcctt  tggagcatg  ggggctgcc  gagccgctt  ccctgagat  gagtaagga  300
ggagccttc  atagaccct  agctggtca  ggctgagag  tggggtcat  aaatgaaat  360
aaatggttc  ctggggcaa  ttaatctgt  gctcagttc  caagaacca  caatggctg  420
tcagttcag  agaaacaag  aggctgagc  gtttgctgt  tagtagttc  tgggggcaa  480
tccaatctc  aattgacag  acagcagca  tccaggtca  tagtgtcag  atagcaaac  540
ggaatcatc  gcggtggca  aaaccagca  aaactgcca  gcatccacc  aatcagcat  600
agtcagcag  actgagcag  gaagcctg  628



<210> 3256
<211> 319
<212> PRT
<213> Rattus norvegicus
<308> P15978
<400> 3256

Met Gly Ala Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Val 
  1               5                  10                  15
Leu Ala Pro Thr Gln Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe 
             20                  25                  30
His Thr Ala Val Ser Arg Pro Gly Leu Gly Glu Pro Arg Phe Ile Ser 
         35                  40                  45
Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Tyr Asp Ser Asp Ala 
     50                  55                  60
Glu Asn Pro Arg Tyr Glu Pro Arg Ala Arg Trp Met Glu Arg Glu Gly 
 65                  70                  75                  80
Pro Glu Tyr Trp Glu Glu Gln Thr Leu Val Ala Lys Gly Gln Glu Leu 
                 85                  90                  95
Asp Tyr Arg Val Ser Leu Arg Asn Leu Leu Ser Tyr Tyr Asn Gln Ser 
             100                105                110
Glu Gly Gly Ser His Thr Ile Gln Arg Met Tyr Gly Cys Asp Val Gly 
         115                120                125
Ser Asp Gly Ser Leu Leu Arg Gly Tyr Glu Gln His Ala Tyr Asp Gly 
     130                135                140
Arg Asp Tyr Ile Ala Leu Asn Glu Asp Leu Lys Thr Trp Ala Val Ala 
 145                150                155                160
Asp Phe Ala Ala Trp Ile Thr Arg Ser Lys Trp Gln Arg Asn Gly Ala 
                 165                170                175
Ala Glu Arg Ser Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
             180                185                190
Leu Arg Tyr Leu Glu Arg Gly Lys Glu Thr Leu Leu Arg Ser Asp Pro 
         195                200                205
Pro Glu Ala His Val Thr Leu His Pro Arg Pro Glu Gly Asp Val Thr 
     210                215                220
Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr 
 225                230                235                240
Trp Gln Leu Asn Gly Glu Asp Leu Thr Gln Asp Met Glu Leu Val Glu 
                 245                250                255
Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val 
             260                265                270
Val Pro Leu Gly Lys Glu Gln Asn Tyr Thr Cys Arg Val Glu His Glu 
         275                280                285
Gly Leu Pro Glu Pro Leu Ser Gln Arg Trp Glu Pro Ser Pro Ser Thr 
     290                295                300
Asp Ser Asn Leu Leu Leu Leu Phe Leu Glu Leu Trp Gln Phe Leu 
 305                310                315



<210> 3257
<211> 2959
<212> DNA
<213> Homo sapiens
<308> I38874
<400> 3257

ggatccggt  tatgccgca  caggcatga  cagcccgaa  atgcgcctg  tggctgcaa  60
gaccgagga  atgacccgc  ttttcggcg  tgaccaggc  ttttcacat  ggctgagcc  120
gtggccact  cacgtctcc  acgatccca  cgcgtaccg  tggcatgcc  agcacaatc  180
cgtggatcg  ctagctgat  ccgaaaaag  ttttgcctt  tgtaaaaaa  ttctcggtc  240
ccccgcaaa  tttcgattc  agatttttt  aaaaccaag  cagaaatac  acacaccgt  300
tgcagataa  ctgtctttc  gaaaaatca  gtgcgatac  aaattttta  cacccctga  360
gtgcgcaaa  tcccgcttc  tgaaaattt  cgtgccgcg  gattttccg  caaaaactt  420
aacgaacgt  cgttataat  gtgtcatga  cttcacgac  aagtaccaa  attggcccg  480
atcatcagc  atggatctc  ctgatgtcg  gctggagtc  gacgcgctc  atgctgccg  540
cgatttaaa  acggtgatc  gatttttcc  agctctcga  acgacggac  cgccagcat  600
acgagactg  gccagtgcc  cgagcgacc  agaaactct  gtggcggat  ttgaggagc  660
ggctgacga  ctgcgtgct  ggcagcgcc  ggaggacgc  cagtagtgg  ggatcgaat  720
agttgcgcc  actgcggtg  cctgattcc  ccccggcct  acccgcgag  acggcgcgc  780
aaatattgc  cagatgcgt  tcgtgccgc  gccagccgc  agcgcgcca  caaacgcca  840
gccgaggag  tggaggcgg  taggtcgca  atggcgctg  aagtgcgtc  cccgagcga  900
attttggcc  tggtcgtca  agagctgga  gcggcagcg  gaattatcc  cgatcgtgg  960
gcggtgccc  caggcatga  aaacatcgt  aatgccgcg  ttcgtgtgg  cgtggccgc  1020
caggacgtg  cagcgccgc  accacctgc  ccgaatcgg  agcagcgtc  cgcgtcgaa  1080
aagcgcaca  gcggcaaga  gcgataagc  gcacgaata  ctgaaaaat  ttgaacgcc  1140
cgtgagcgg  aactcacag  gcgtcggct  acccccagt  caaacctgg  agaaagcgc  1200
caaaaatga  tctagcgga  tcacgagac  ttgacacac  ggcctggaa  ttttccgct  1260
atctgttcg  cacccatcc  gagctcgcg  tgcgatcac  tggctggac  agcgaagac  1320
gccgcgaat  cctcgctca  ctgggcaga  aaaatttcc  gggcagcaa  acccgcgac  1380
tcgccagcg  ttggatcaa  gacccggac  cgggagaaa  acagccgaa  ttataccga  1440
ttggttcaa  atcgcttgc  cggtgccag  atgttgctc  gacgcacgc  cagcacgca  1500
ccgtgcttg  cctggacat  gatgtgccg  gccaccagg  cggcgggaa  atcgagcac  1560
taaaccccg  ggtctacgc  attttggag  gctgggcac  cctggaaaa  gcgccagct  1620
ggatcggcg  gaatccact  agcgggaaa  gccagctca  ctggctcat  gatccggtg  1680
atgccgcag  aggcatgag  agcccgaat  tgcgcctgc  ggctgcaac  accgaggaa  1740
tgacccgcg  tttcggcgc  gaccaggct  tttcacata  gctgagccg  tggccactg  1800
acgtctccg  cgatcccac  gcgtaccgc  ggcatgccc  gcacaatcg  gtggatcgc  1860
tagctgatc  tatggaggt  gctcgcatg  tctcaggca  agaaaaacc  aaaaaacgc  1920
atgagcagg  gttttctag  ggacgggca  gtatcgaag  ggcaagaaa  gccactgcg  1980
aagcaaaag  acttgccac  cttgaagca  gcctgccga  cgccgctga  gcgtctgga  2040
agctgatcg  cggcgtccg  gtcctctgg  ctgctccag  gcgtgccgc  cgtgatgag  2100
cggcttttc  ccacgcttt  actgtggga  accagttaa  agcggctgg  gagcgccta  2160
aagacacca  gatcatcga  gcctacgag  gtgcctaca  cgtcgctca  gcggtcgga  2220
cagacggcc  tgagcctga  ctgccgccg  tgcgtgacc  ccagacgat  gcgcgacgt  2280
tgcgcggct  cgtcgctaa  ggccagcca  tcgtccctg  tcgtcagac  gagacgcag  2340
gcagccgag  gcgaaaagc  ctggccact  tgggaagac  tggcggtaa  aaggccgca  2400
aacgctgga  agacccaaa  agtgagtac  cccgagcac  gcgagaaaa  ctagctaag  2460
ccagtcaac  acaagctag  aaagctaaa  gaaatcgct  gaccattgc  ggttggttt  2520
tgactgttg  gggagagac  ggctcgtgg  cgacaatca  tgaagctat  tctgaattt  2580
gcgtgtcac  tcagaccgt  aatagagca  ttaagtctg  gggcattga  cttccacga  2640
gacgccgta  agcttccca  taaatgtgc  atctcgtag  cagaaaacg  ttccccccg  2700
aggggtctc  ctcttggcc  cctttctag  tcgggctga  tgctcttga  gctctctag  2760
ggggctcac  ccataggca  ataacggtt  cccaccggc  cacctcgta  gcgcacaag  2820
actgctccc  aagatcgcc  agctgatct  atggaggtt  ctcgcatga  cctttttga  2880
aatctcatg  ccaaaatcc  ttaacgtga  ttttcgttc  actgagcgt  agaccccgt  2940
gaaaagatc  ccgggtacc  2959



<210> 3258
<211> 764
<212> DNA
<213> Rattus norvegicus
<308> M10934
<400> 3258

aaggagaac  tcgacaagg  tcgtttctc  gggctctgg  atgccatcg  caaaaagga  60
cccgagggt  tctttttgc  agacaacat  atcgctgag  tttctgtcg  cgagaaggg  120
catatgagc  ctacagcca  gggacgagt  cgtcttctg  gcaactggg  agtgtgtgc  180
gacatggtg  gcactttca  agatacaga  gatcctgcc  agttcaaga  gaagtactg  240
ggtgtagcc  cctttctcc  gcgaggaaa  gatgaccac  ggatcatcg  tacggacta  300
gacaccttc  ctctgcagt  ttcctgccg  ctgcagaat  tggatggca  ctgtgcaga  360
agctactcc  ttgtgtttt  tcgtgaccc  aatggcctg  ccccggaga  acggaggct  420
gtgaggcag  gacaggagg  gctgtgcct  gagaggcag  acagatgga  cgagcacaa  480
ggttactgt  aaagcagac  ctcaagaaa  agtttgtag  aacgtcaag  atgtataaa  540
ttggaaaac  tctgattag  tctcatcca  tcttcatct  tatttatct  agaagttta  600
tttccccac  tcccctccc  tctctaggt  gacattaaa  ccatcgtcc  aatacatgg  660
aatgcctga  tccattcac  caaacgtgt  tcttactga  aagttcccc  agagacgtt  720
gaggcttgg  attccaaac  tgatttatt  aacgtatag  cacc  764



<210> 3259
<211> 201
<212> PRT
<213> Rattus norvegicus
<308> AAA42020
<400> 3259

Met Glu Trp Val Trp Ala Leu Val Leu Leu Ala Ala Leu Gly Gly Gly 
  1               5                  10                  15
Ser Ala Glu Arg Asp Cys Arg Val Ser Ser Phe Arg Val Lys Glu Asn 
             20                  25                  30
Phe Asp Lys Ala Arg Phe Ser Gly Leu Trp Tyr Ala Ile Ala Lys Lys 
         35                  40                  45
Asp Pro Glu Gly Leu Phe Leu Gln Asp Asn Ile Ile Ala Glu Phe Ser 
     50                  55                  60
Val Asp Glu Lys Gly His Met Ser Ala Thr Ala Lys Gly Arg Val Arg 
 65                  70                  75                  80
Leu Leu Ser Asn Trp Glu Val Cys Ala Asp Met Val Gly Thr Phe Thr 
                 85                  90                  95
Asp Thr Glu Asp Pro Ala Lys Phe Lys Met Lys Tyr Trp Gly Val Ala 
             100                105                110
Ser Phe Leu Gln Arg Gly Asn Asp Asp His Trp Ile Ile Asp Thr Asp 
         115                120                125
Tyr Asp Thr Phe Ala Leu Gln Tyr Ser Cys Arg Leu Gln Asn Leu Asp 
     130                135                140
Gly Thr Cys Ala Asp Ser Tyr Ser Phe Val Phe Ser Arg Asp Pro Asn 
 145                150                155                160
Gly Leu Thr Pro Glu Thr Arg Arg Leu Val Arg Gln Arg Gln Glu Glu 
                 165                170                175
Leu Cys Leu Glu Arg Gln Tyr Arg Trp Ile Glu His Asn Gly Tyr Cys 
             180                185                190
Gln Ser Arg Pro Ser Arg Asn Ser Leu 
         195                200



<210> 3260
<211> 919
<212> DNA
<213> Homo sapiens
<308> NM_006744
<400> 3260

cgctcgcct  cctcgctcc  cgcgcgccc  gacgcggcg  ccaggcttg  gcgtggttc  60
cctcccggt  ggcggattc  tgggcaaga  gaagtgggt  tgggcgctc  tgctgttgg  120
ggcgtgggc  gcggccgag  gcgactgcc  agtgagcag  ttccgagtc  aggagaact  180
cgacaaggc  cgcttctct  ggacctggt  cgccatggc  aagaaggac  ccgagggcc  240
ctttctgca  gacaacatc  tcgcggagt  ctcggtgga  gagaccggc  agatgagcg  300
cacagccaa  ggccgagtc  gtcttttga  taactggga  gtgtgcgca  acatggtgg  360
caccttcac  gacaccgag  accctgcca  gttcaagat  aagtactgg  gcgtagcct  420
ctttctgca  aaaggaaat  atgaccact  gatcgtcga  acagactac  acacgtatg  480
cgtacagta  tcctgccgc  tcctgaacc  cgatggcac  tgtgctgac  gctactcct  540
cgtgttttc  cgggacccc  acggcctgc  cccagaagc  cagaagatt  taaggcagc  600
gcaggagga  ctgtgcctg  ccaggcagt  caggctgat  gtccacaac  gttactgcg  660
tggcagatc  gaaagaaac  ttttgtagc  atatcaaga  tctagtttc  tctgagaac  720
tctgattag  tctcagtct  cagctctat  tatcttagg  gtttaattt  cccttctct  780
cccatcttc  ctcagttcc  ataaaacct  cattacaca  aaagataca  gtgggggtc  840
gtgaatctg  ttgcctttc  tgaaagttt  tggggctta  gattccaga  tctgattca  900
taaactata  tcacccgtg  919



<210> 3261
<211> 201
<212> PRT
<213> Homo sapiens
<308> P02753
<400> 3261

Met Lys Trp Val Trp Ala Leu Phe Leu Leu Ala Ala Leu Gly Ser Gly 
  1               5                  10                  15
Arg Ala Glu Arg Asp Cys Arg Val Ser Ser Phe Arg Val Lys Glu Asn 
             20                  25                  30
Phe Asp Lys Ala Arg Phe Ser Gly Thr Trp Tyr Ala Met Ala Lys Lys 
         35                  40                  45
Asp Pro Glu Gly Leu Phe Leu Gln Asp Asn Ile Val Ala Glu Phe Ser 
     50                  55                  60
Val Asp Glu Thr Gly Gln Met Ser Ala Thr Ala Lys Gly Arg Val Arg 
 65                  70                  75                  80
Leu Leu Asn Asn Trp Asp Val Cys Ala Asp Met Val Gly Thr Phe Thr 
                 85                  90                  95
Asp Thr Glu Asp Pro Ala Lys Phe Lys Met Lys Tyr Trp Gly Val Ala 
             100                105                110
Ser Phe Leu Gln Lys Gly Asn Asp Asp His Trp Ile Val Asp Thr Asp 
         115                120                125
Tyr Asp Thr Tyr Ala Val Gln Tyr Ser Cys Arg Leu Leu Asn Leu Asp 
     130                135                140
Gly Thr Cys Ala Asp Ser Tyr Ser Phe Val Phe Ser Arg Asp Pro Asn 
 145                150                155                160
Gly Leu Pro Pro Glu Ala Gln Lys Ile Val Arg Gln Arg Gln Glu Glu 
                 165                170                175
Leu Cys Leu Ala Arg Gln Tyr Arg Leu Ile Val His Asn Gly Tyr Cys 
             180                185                190
Asp Gly Arg Ser Glu Arg Asn Leu Leu 
         195                200



<210> 3262
<211> 824
<212> DNA
<213> Rattus norvegicus
<308> M11071
<400> 3262

cgatggaac  ttccaaaag  gggcatctg  ggtggtgcc  cttgggaag  agcagaatt  60
cacatgcct  gtggagcat  aggggctgc  tgagccgct  acccagaga  gggagcctt  120
tccatcgac  gactccaac  tggaaacct  tgtcattta  gtcatcctt  gagctgtgg  180
catcattgc  gctgtgatc  ttgtagctg  ggtggctgt  gtgatgaag  ggaggagaa  240
cacaggtgg  aaagtagga  tctacgccc  tgctccaag  agggacagc  ctgagagct  300
tgatgtgtc  ctctcagat  gtaaagcat  aagacagct  cctggagtg  actgagtga  360
agacgatgt  ttcaggtct  tcctgtgac  tccagagtc  tcagttctc  ttagacacc  420
gtgtctgat  ttccctgtg  ttctatggc  tctgtgtga  gaactgtgg  gcccagcct  480
ccctgcaca  ctggaccct  tccctgcac  gcctgtgtt  ccttccaca  ccaacctcg  540
tggtctagc  tggggttgg  ggctgggga  atctgcacc  tatcactca  tgctgcttc  600
agctgcaac  cctcacttc  acactgaga  taagaatct  agtgtgggg  tggagagat  660
gctcagcgg  taagagcac  cgactgctc  tctagaggt  atgagttca  ttcccagca  720
ccgcatggt  gctcacaac  atctataaa  agatccgat  ccctcttct  gtgtatctg  780
agacagcta  agtgtactt  tatataata  actaaataa  tctc  824



<210> 3263
<211> 319
<212> PRT
<213> Rattus norvegicus
<308> P15978
<400> 3263

Met Gly Ala Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Val 
  1               5                  10                  15
Leu Ala Pro Thr Gln Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe 
             20                  25                  30
His Thr Ala Val Ser Arg Pro Gly Leu Gly Glu Pro Arg Phe Ile Ser 
         35                  40                  45
Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Tyr Asp Ser Asp Ala 
     50                  55                  60
Glu Asn Pro Arg Tyr Glu Pro Arg Ala Arg Trp Met Glu Arg Glu Gly 
 65                  70                  75                  80
Pro Glu Tyr Trp Glu Glu Gln Thr Leu Val Ala Lys Gly Gln Glu Leu 
                 85                  90                  95
Asp Tyr Arg Val Ser Leu Arg Asn Leu Leu Ser Tyr Tyr Asn Gln Ser 
             100                105                110
Glu Gly Gly Ser His Thr Ile Gln Arg Met Tyr Gly Cys Asp Val Gly 
         115                120                125
Ser Asp Gly Ser Leu Leu Arg Gly Tyr Glu Gln His Ala Tyr Asp Gly 
     130                135                140
Arg Asp Tyr Ile Ala Leu Asn Glu Asp Leu Lys Thr Trp Ala Val Ala 
 145                150                155                160
Asp Phe Ala Ala Trp Ile Thr Arg Ser Lys Trp Gln Arg Asn Gly Ala 
                 165                170                175
Ala Glu Arg Ser Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
             180                185                190
Leu Arg Tyr Leu Glu Arg Gly Lys Glu Thr Leu Leu Arg Ser Asp Pro 
         195                200                205
Pro Glu Ala His Val Thr Leu His Pro Arg Pro Glu Gly Asp Val Thr 
     210                215                220
Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr 
 225                230                235                240
Trp Gln Leu Asn Gly Glu Asp Leu Thr Gln Asp Met Glu Leu Val Glu 
                 245                250                255
Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val 
             260                265                270
Val Pro Leu Gly Lys Glu Gln Asn Tyr Thr Cys Arg Val Glu His Glu 
         275                280                285
Gly Leu Pro Glu Pro Leu Ser Gln Arg Trp Glu Pro Ser Pro Ser Thr 
     290                295                300
Asp Ser Asn Leu Leu Leu Leu Phe Leu Glu Leu Trp Gln Phe Leu 
 305                310                315



<210> 3264
<211> 760
<212> DNA
<213> Rattus norvegicus
<308> M11596
<400> 3264

acaccatgg  cttctggaa  ttctttcct  ttctggctc  cagcagcat  tgggtcctg  60
gcctggcca  cagcctcca  gcagcccct  tcaggtcag  tttggagag  agcctagac  120
tgggcaccc  cagcgacca  gaaaaacac  tcttgcttg  tgcattgat  caggactat  180
aacagaagg  caggaagct  gaacaggag  agcaagaga  tgagggctc  aggaaaggc  240
cctcctcca  tgtcatttc  cagaagaga  cctgcaaca  cgccacctg  gtgacccat  300
ggctggcag  cttgctgcg  aggtcggga  gtgtggtga  ggacaactt  gtgcccacc  360
atgtgggct  caaagcctt  ggccggcgc  gcagggacc  tcgggtctg  ggaactaac  420
ctccaggaa  aaggttaca  aaagttgaa  tcaccacgc  tattaattt  tattaacaa  480
aaccctatt  agaaggccc  atggacgat  tgtatgttt  catcctgaa  gatactgag  540
gaaaacacc  ttgtcactt  agagaaatg  aaccaagta  aaatgagtt  attctgtgt  600
cgtttgcat  atttttata  tgagtctat  gccagtcaa  tatgatggt  tctcctgct  660
gcatccttt  cagcaaacc  aataggttc  ccaagagcc  tccagacgg  ggtagcagc  720
ctggtgaac  tcagggaga  gtgatatca  tgcctcttgt  760



<210> 3265
<211> 134
<212> PRT
<213> Rattus norvegicus
<308> P10093
<400> 3265

Met Asp Phe Trp Lys Phe Phe Pro Phe Leu Ala Leu Ser Ser Met Trp 
  1               5                  10                  15
Val Leu Cys Leu Ala Ser Ser Leu Gln Ala Ala Pro Phe Arg Ser Ala 
             20                  25                  30
Leu Glu Ser Ser Leu Asp Leu Gly Thr Leu Ser Asp Gln Glu Lys His 
         35                  40                  45
Leu Leu Leu Ala Ala Leu Ile Gln Asp Tyr Glu Gln Lys Ala Arg Lys 
     50                  55                  60
Leu Glu Gln Glu Glu Gln Glu Thr Glu Gly Ser Arg Lys Gly Ser Ser 
 65                  70                  75                  80
Ser Ser Val Ile Ser Gln Lys Arg Ser Cys Asn Thr Ala Thr Cys Val 
                 85                  90                  95
Thr His Arg Leu Ala Gly Leu Leu Arg Arg Ser Gly Gly Val Val Lys 
             100                105                110
Asp Asn Phe Val Pro Thr Asn Val Gly Ser Lys Ala Phe Gly Arg Arg 
         115                120                125
Arg Arg Asp Leu Arg Val 
     130



<210> 3266
<211> 681
<212> DNA
<213> Homo sapiens
<308> M64486
<400> 3266

gcctctctg  tccaagcca  ctcccgcca  agaggtgtc  tgggcttcc  aaagttctc  60
cccttcctg  ctctcagca  cttggtcct  ttgcaggca  gcagcctcc  tgcagcacc  120
ttcaggtct  ccctggaga  cagcccagc  gacccggcc  cgctcagtg  ggacgaagc  180
cgcctcctg  tggctgcac  ggtgcagga  tatgtgcag  tgaaggcca  tgagctgga  240
caggagcaa  agagagagg  ctccagcct  gacagcccc  gatctaagc  gtgcggtaa  300
ctgagtact  gcatgctgg  cacatacac  caggacttc  acaagtttc  cacgttccc  360
caaactgca  ttggggttg  agcacctgg  aagaaaagg  atatgtcca  cgacttgga  420
agagaccat  gccctcata  tcattgccc  gaagagagc  tgtgacact  ccacctgtg  480
gactcatcg  ctggcaggc  tgctgagca  atcaggggg  gtggtgaag  acaactttg  540
gcccaccaa  gtgggttcc  aagcctttg  caggcgccg  agggacctt  aagcctgag  600
agctgaatg  ctcaagaag  tcacaataa  gctgaactc  ttttaatgt  taatgaaag  660
aatttgtag  aaaggctcc  t  681



<210> 3267
<211> 141
<212> PRT
<213> Homo sapiens
<308> P01258
<400> 3267

Met Gly Phe Gln Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
  1               5                  10                  15
Leu Leu Gln Ala Gly Ser Leu His Ala Ala Pro Phe Arg Ser Ala Leu 
             20                  25                  30
Glu Ser Ser Pro Ala Asp Pro Ala Thr Leu Ser Glu Asp Glu Ala Arg 
         35                  40                  45
Leu Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser 
     50                  55                  60
Glu Leu Glu Gln Glu Gln Glu Arg Glu Gly Ser Ser Leu Asp Ser Pro 
 65                  70                  75                  80
Arg Ser Lys Arg Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr 
                 85                  90                  95
Thr Gln Asp Phe Asn Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly 
             100                105                110
Val Gly Ala Pro Gly Lys Lys Arg Asp Met Ser Ser Asp Leu Glu Arg 
         115                120                125
Asp His Arg Pro His Val Ser Met Pro Gln Asn Ala Asn 
     130                135                140



<210> 3268
<211> 1696
<212> DNA
<213> Rattus norvegicus
<308> M12156
<400> 3268

cgctgaacg  tctcatcat  ctaccgtca  gtctaagtc  gagtccccc  aggaaccgg  60
acagctgcg  aagctcttc  ttggagggc  gagcttcga  acaaccgac  agagtctga  120
gagccattt  gagcaatgg  gaacactca  cgactgtgt  gtaatgaga  atccaaaca  180
caaaagatc  agaggcttt  ggtttgtca  atatgccac  gtggaggaa  tggatgctg  240
catgaatgc  agaccacac  aagtggatg  aagagttgt  gaacctaag  gagctgtgt  300
aagagaaga  tctcagaga  caggtgccc  cttaactgt  aagaagatc  ttgttggcg  360
tattaaaga  gacactgaa  aacatcacc  acgagatta  tttgagcag  atgggaaaa  420
tgaagtgat  gaaattatg  ctgacagag  cagtggaaa  aagagggga  ttgcgtttg  480
cacctttga  gaccatgac  ctgtggata  gattgttat  cagaaatac  atactgtga  540
tggccacaa  tgtgaagta  gaaaggctc  gtgcaaaca  gagatggct  gtgcttcat  600
cagccagag  ggtcgaagt  gttccggaa  ctttggtgg  ggtcgtgga  gtggtttcg  660
tggcaatga  aattttggt  gaggaggga  cttcagtgg  cgtggtggc  ttggtggca  720
ccgtggtgg  ggtggatat  gtggcagtg  ggatggcta  aatggattt  gcaatgatg  780
aagcaattt  ggaggtggt  gaagctaca  tgattttgg  aattacaac  accagtcat  840
aaattttgg  ccgatgaaa  gaggaaact  tggaggcag  agctctggc  cttatggtg  900
tggaggcca  tactttgct  aaccacgaa  ccaaggtgg  tatggaggt  ccagcagca  960
cagtagcta  ggcagtggc  ggaggttct  attacagcc  ggaaacaaa  cttagcagg  1020
gagccagag  agtgacagg  aagctacag  ttacaacag  tttgtgaac  cagccaagc  1080
cagtggtgg  agggcctag  tgctacaaa  aagacatgt  ttagacaat  ctcatgtgt  1140
tgggcaaaa  ctccaggac  gtatctgtg  ctaattgta  aacaggtta  tttagtttc  1200
gttctgtgg  aagtgtaaa  cattccaac  aagggtttt  ctgtagacc  ttttcaccc  1260
tgctgttga  tgctaaatg  aaaagtctg  tcatgacgc  gaataaatg  gtctttttt  1320
ttttttttt  atgtgctgt  taaagttag  ctactctga  gccatcttg  taaacttcc  1380
caacagtgt  aagttagaa  tccttcagg  tggtgccaa  ttccatttg  aatttattt  1440
tggttgctt  ggtggagaa  ccattgtct  caaaaacct  ggtgttgct  aactgccag  1500
tactgttgt  acttaatga  tttcaccat  taaagggtc  tccaagcaa  atcacaatt  1560
ggttataaa  tggttgttg  acacctatg  agagaaaat  gaataacgg  ctcagataa  1620
ataagagat  ggaatgaag  ttgtgtatc  tccattatc  tgtgtactc  ataaacgat  1680
taattctct  gaatgg  1696



<210> 3269
<211> 319
<212> PRT
<213> Rattus norvegicus
<308> P04256
<400> 3269

Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu Phe 
  1               5                  10                  15
Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser His 
             20                  25                  30
Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp Pro 
         35                  40                  45
Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr Val 
     50                  55                  60
Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp Gly 
 65                  70                  75                  80
Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln Arg 
                 85                  90                  95
Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys 
             100                105                110
Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr Gly 
         115                120                125
Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys Lys 
     130                135                140
Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp Lys 
 145                150                155                160
Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu Val 
                 165                170                175
Arg Lys Ala Leu Cys Lys Gln Glu Met Ala Ser Ala Ser Ser Ser Gln 
             180                185                190
Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly 
         195                200                205
Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly Arg 
     210                215                220
Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser Gly 
 225                230                235                240
Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly Gly 
                 245                250                255
Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe 
             260                265                270
Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr 
         275                280                285
Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly Tyr 
     290                295                300
Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
 305                310                315



<210> 3270
<211> 620
<212> DNA
<213> Homo sapiens
<308> AI339411
<400> 3270

tcagggttt  gctttttat  gacacaaac  cacaaaggc  gctgtggta  tggggtggt  60
gggtacaca  aagcagaaa  cgcacttca  acatttagg  ctcatttag  caatgagga  120
gctgagcct  tccctccac  tcccattgc  atggttggg  caataaccc  ccctaatcc  180
agctcagtg  gtagaggga  tgacctccc  acccaggaa  tccccattt  tggttgcaa  240
ggcccaggt  ctgaccatc  cactctgta  ttccctgct  catcattac  aaatccatt  300
tagccatcc  cactgccac  atatccacc  ccaccacgg  tgccaccaa  gccaccacg  360
ccactgaag  ttcctccac  accgaagtt  tcattccca  cgaaaccac  tccacgacc  420
ccaccaaag  ttccagaac  acttcgacc  ctttggctg  atgaagcac  agccatctc  480
tgctgtgac  gggcttttc  aacttcaca  ttgtggcca  tcacagtat  gtattcctg  540
gtgacaatc  tatccacgg  gtcatggtc  tcaaggtta  aatgcagag  ccctttctt  600
ccactgctc  tagtatgatt  620



<210> 3271
<211> 320
<212> PRT
<213> Homo sapiens
<308> XP_015755
<400> 3271

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
  1               5                  10                  15
Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
             20                  25                  30
His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
         35                  40                  45
Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
     50                  55                  60
Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
 65                  70                  75                  80
Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                 85                  90                  95
Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
             100                105                110
Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
         115                120                125
Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
     130                135                140
Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
 145                150                155                160
Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                 165                170                175
Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
             180                185                190
Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
         195                200                205
Gly Phe Gly Gly Asn Asp Asn Phe Gly His Gly Gly Asn Phe Ser Gly 
     210                215                220
Arg Gly Gly Phe Gly Gly Ser Arg Ala Gly Gly Arg Tyr Gly Gly Ser 
 225                230                235                240
Gly Asp Gly Ser Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
                 245                250                255
Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
             260                265                270
Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Asn Ser Gly Pro 
         275                280                285
Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly 
     290                295                300
Tyr Gly Gly Ser Ser Ser Ser Ser Ser Cys Val Ser Gly Arg Arg Phe 
 305                310                315                320



<210> 3272
<211> 3108
<212> DNA
<213> Rattus norvegicus
<308> M12492
<400> 3272

tgagcatcg  gatccccgc  gggctcacg  agctgctgc  gggcttcac  gtggaggtg  60
tgaggcacc  gcccgccga  ctgctggag  tcgcgctgc  gcacttcac  cggctgcag  120
aggagaacg  gcgcaaggg  gccgcgcgc  tcggccatg  gggcaggac  tggggggac  180
cgggcgcag  cgccggggg  ggaaccccc  gtaagggtg  caacttcgc  gaggagccc  240
tgcgctccg  ttccgagaa  ggcgaagag  aggaggccg  ggaagcagg  gcgttcaac  300
ctccagtta  aaaccggtt  acaaggcgt  cctcggtat  tgcagaagc  tataatcct  360
atgaagaag  agatgatgc  gagtccagg  taatacatc  caaaactga  gatcaaaga  420
acagattgc  agaagcctg  aaagacatc  tgctgttta  gaacctgga  ccagaacag  480
tgtctcaag  attagatgc  atgtttgaa  aattggtca  agaagggga  cacgtaatc  540
atcaaggtg  tgatggtga  aacttttac  tcatcgaca  aggaacatt  gatatttat  600
taaaatgtg  tggcgttgg  agatgcgtt  gtaactatg  caatcgtgg  agttttgga  660
aactggcct  aatgtacaa  acacccaga  cagctacaa  cactgctac  tctcctggt  720
ctctgtggg  tttggacag  gtgaccttc  ggagaataa  agtaaaaaa  aatgccaaa  780
agaggaaga  gtacgagag  tttattgag  cactgccat  cctcaagtc  ctggaggtt  840
ctgaacgcc  gaaggtggt  gatgtgatt  gcaccaaag  ttacaacga  ggagaacag  900
tcattgctc  gggagactc  gcggattcg  tcttcattg  agaatctgg  gaagtgaga  960
ttactatga  gagaaaggg  aaatcagac  tcgaagaga  cggtgctgt  gaaatcgct  1020
ggtgtctcc  gggacagta  tttggagag  ttgccctgg  cactaacaa  ccaagagca  1080
catctgcac  cgccattgg  actgtcaaa  gcttagcca  ggatgtgca  gcatttgag  1140
ggcttctgg  accttgcat  gaaattatg  agaggaata  cgccaccta  gaggagcaa  1200
tagttgcac  gtttgggac  aacatggat  ttgttgagc  cactgcatg  agcaaaagt  1260
tggggaaga  agcgcgtta  tgaagcagt  acatagcag  ggttagtcc  ccgaggatg  1320
gttcgtgta  atcaagcat  ttctgtgac  tcaggtttt  cttttttaa  cagaaacca  1380
ttacaatat  tcagtgaac  gtagtgatt  aatagtagg  tttaacatc  ctttctaat  1440
ggtagttca  aaattaaca  aatcataaa  acgactttc  atttcataa  actgactga  1500
aggtttatt  aaatggtta  aatatattg  gagcataca  gtttaagaa  ataattaaa  1560
gatgtactc  taggccgac  tgtgtgttt  gattattca  gtatcgtgt  agtgactct  1620
cccctttac  agggaagct  gcacgtggc  tgtgcactc  cattctttt  ataactcgt  1680
agacagtaa  attgccaat  atttcattt  ctacctttt  tggcttagt  agttatgtg  1740
tagccttgg  ctatcggta  catggtgtg  aaatcatat  caattttaa  attttttat  1800
tttttgcaa  aaactacat  tcaacttct  tgacaactg  cagccagca  cctgggtag  1860
tgagtggct  ttggggcct  gtaatttag  tgttgtgat  attgggcag  gagcctttt  1920
ggatgaaag  tcataactg  gtctttcat  atcctttct  catcatcac  gcttcccgc  1980
ttgtattta  caacctcct  ggttcctta  agatcgcat  ttgacgttt  atgtcacaa  2040
ggttgtatt  gttctcaag  caatttcat  ttaatctga  aatttgttt  gtcctctaa  2100
agtcccgaa  cttctattc  gaaaaatga  agcttccct  tcaaaagac  tttgggatt  2160
ttagcccac  cccacagaa  atggctttg  tctgtaggt  ccagtgctg  gaccctgtg  2220
gtgtgtctg  ggtcccctg  ccttccctg  cctgagcac  agccagcga  cacattggt  2280
agcagccaa  caagtgcgt  tgccctttc  aaccttcaa  aacttcaac  acggtggtg  2340
aaagaagtc  gtgtataag  aaagccata  atgagtatt  atgggattt  tctctatcc  2400
acaccttat  aggccttgt  cttagcttt  aagtcagcc  acagttaaa  gtacacaaa  2460
tacaaaatt  tttttggtc  acaagatac  tacttttat  ccaaatacg  tgaattgtt  2520
aaaccaaag  aatatactt  tatgtgatt  tcaggcccc  tgaccaaat  tctaaaggc  2580
ttaattctc  ccagtttaa  tcatgttga  atgggtaat  ttactttgg  gaacatgtt  2640
ctaaggaac  gaggtatca  gtatgttaa  ttcatctgt  actgtctcg  tcttacaag  2700
gaatgttta  agtcctacg  gtacgctat  ctgttacct  cacctttag  cgtgctttt  2760
aaatgtcag  cttgcaaaa  ctttacgta  gaaaaaaag  tctctacat  aaggtaaca  2820
gttttctat  tcagagttc  gaagccatg  gttcaaaca  gaaacaaat  ccaaaaaca  2880
aaaaacaag  acaaaagcc  cccaaattc  tggctcatc  ttctgtgtt  ttttctctc  2940
tttccaagt  ctctttggt  gcattgcat  ggctgagtg  tgacgttca  ggaaaccaa  3000
gcctgtgga  taaagagcc  caaccaagg  tacagaggc  agctgtgtt  ttttcagta  3060
tgttggtta  atttaaatt  tccttataa  aaagcacac  tttataat  3108



<210> 3273
<211> 415
<212> PRT
<213> Rattus norvegicus
<308> P12369
<400> 3273

Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe Thr 
  1               5                  10                  15
Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala Leu 
             20                  25                  30
Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg Lys Gly Ala Ala 
         35                  40                  45
Arg Phe Gly His Glu Gly Arg Thr Trp Gly Asp Ala Gly Ala Ala Ala 
     50                  55                  60
Gly Gly Gly Thr Pro Ser Lys Gly Val Asn Phe Ala Glu Glu Pro Met 
 65                  70                  75                  80
Arg Ser Asp Ser Glu Asn Gly Glu Glu Glu Glu Ala Ala Glu Ala Gly 
                 85                  90                  95
Ala Phe Asn Ala Pro Val Ile Asn Arg Phe Thr Arg Arg Ala Ser Val 
             100                105                110
Cys Ala Glu Ala Tyr Asn Pro Asp Glu Glu Glu Asp Asp Ala Glu Ser 
         115                120                125
Arg Ile Ile His Pro Lys Thr Asp Asp Gln Arg Asn Arg Leu Gln Glu 
     130                135                140
Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Pro Glu Gln Met 
 145                150                155                160
Ser Gln Val Leu Asp Ala Met Phe Glu Lys Leu Val Lys Glu Gly Glu 
                 165                170                175
His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr Val Ile Asp 
             180                185                190
Arg Gly Thr Phe Asp Ile Tyr Val Lys Cys Asp Gly Val Gly Arg Cys 
         195                200                205
Val Gly Asn Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu Ala Leu Met 
     210                215                220
Tyr Asn Thr Pro Arg Ala Ala Thr Ile Thr Ala Thr Ser Pro Gly Ala 
 225                230                235                240
Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile Val Lys Asn 
                 245                250                255
Asn Ala Lys Lys Arg Lys Met Tyr Glu Ser Phe Ile Glu Ser Leu Pro 
             260                265                270
Phe Leu Lys Ser Leu Glu Val Ser Glu Arg Leu Lys Val Val Asp Val 
         275                280                285
Ile Gly Thr Lys Val Tyr Asn Asp Gly Glu Gln Ile Ile Ala Gln Gly 
     290                295                300
Asp Ser Ala Asp Ser Phe Phe Ile Val Glu Ser Gly Glu Val Arg Ile 
 305                310                315                320
Thr Met Lys Arg Lys Gly Lys Ser Asp Ile Glu Glu Asn Gly Ala Val 
                 325                330                335
Glu Ile Ala Arg Cys Leu Arg Gly Gln Tyr Phe Gly Glu Leu Ala Leu 
             340                345                350
Val Thr Asn Lys Pro Arg Ala Ala Ser Ala His Ala Ile Gly Thr Val 
         355                360                365
Lys Cys Leu Ala Met Asp Val Gln Ala Phe Glu Arg Leu Leu Gly Pro 
     370                375                380
Cys Met Glu Ile Met Lys Arg Asn Ile Ala Thr Tyr Glu Glu Gln Leu 
 385                390                395                400
Val Ala Leu Phe Gly Thr Asn Met Asp Ile Val Glu Pro Thr Ala 
                 405                410                415



<210> 3274
<211> 3259
<212> DNA
<213> Homo sapiens
<308> M31158
<400> 3274

gacgcgcgc  gggagccgg  ggccgggcc  gccggcgcc  gggcccagt  cgccgcgct  60
gcagccggt  gcgcgccag  cgtaggcgt  gctcggcag  cgcggggcc  taggcgtgc  120
ggggagggg  cgagggcgg  caggcgcct  ccgccccgg  ggcaggatg  gcatcgaga  180
cccggcggg  ctgacggag  tgctgcagg  cttcacggt  gaggtgctg  ggcaccagc  240
cgcggacct  ctggagttc  cgctgcagc  cttcacccg  ctgcagcag  agaacgagc  300
caaaggcac  gcgcgcttc  gccatgagg  caggacctg  ggggacctg  gcgccgctg  360
cgggggcgg  acccccagc  agggggtca  cttcgccga  gagcccatg  agtccgact  420
cgaggacgg  gaggaggag  aggcggcgc  cgcggacgc  ggggcgttc  atgctccag  480
aataaaccg  ttcacaagg  gtgcctcag  atgtgcaga  gcttataat  ctgatgaag  540
agaagatga  gcagagtcc  ggattatac  tccaaaaac  gatgatcaa  gaaataggt  600
gcaagaggc  tgcaaagac  tcctgctgt  taagaatct  gatccggag  agatgtctc  660
agtattaga  gccatgttt  aaaaattgg  caaagatgg  gagcatgta  ttgatcaag  720
tgacgatgg  gacaacttt  atgtaattg  tagaggcac  tttgatatt  atgtgaaat  780
tgatggtgt  ggaagatgt  ttggtaact  tgataatcg  gggagtttc  gcgaactgg  840
cttaatgta  aatacaccc  gagcagcta  aatcactgc  acctctcct  gtgctctgt  900
gggtttgga  agggtaacc  tcaggagaa  aattgtgaa  aacaatgcc  aaaagagaa  960
aatgtatga  agctttatt  agtcactgc  attccttaa  tctttggag  tttctgaac  1020
cctgaaagt  gtagatgtg  taggcacca  agtatacaa  gatggagaa  aaatcattg  1080
tcagggaga  tcggctgat  cttttttca  tgtagaatc  ggagaagtg  aaattacta  1140
gaaaagaaa  ggtaaatca  aagtggaag  gaatggtgc  gtagaaatg  ctcgatgct  1200
gcggggaca  tactttgga  agcttgccc  ggtaactaa  aaacctcga  cagcttctg  1260
ccacgccat  gggactgtc  aatgtttag  aatggatgt  caagcattt  aaaggcttc  1320
gggaccttg  atggaaatt  tgaaaagga  catcgctac  tatgaagaa  agttagttg  1380
cctgtttgg  acgaacatg  atattgttg  acccactgc  tgaagcaaa  gtatggagc  1440
agacctgta  tgacaaaat  acacagtag  ggttagtcc  ctgagaatg  gtttgtgta  1500
atgccaagc  ttttctgtg  tttcaggtt  tttcctttt  ttacattta  aacgtatca  1560
taaacagta  tgatttaat  gtcaatagg  tttaacatc  ctttctaaa  agtagttca  1620
aaaaaaatc  acatactga  aaaatgact  tgtactcca  aaaattatg  ctgaaaggt  1680
tattaaaat  attgtaata  atagaaagt  tctgtgttt  agaagataa  taaaggatg  1740
tatcatagg  tatatgtgt  ttacttatt  agactgata  tcatattag  gactatccc  1800
atgtaagag  gcacttggc  attaaacat  ctacacagc  tggcatcac  tttttttat  1860
actcattaa  cacagtaaa  ttttaatca  ttttgtttt  aagttttct  gcttgataa  1920
ttatgtgct  ccttggcct  ttggtgaaa  ggtataaaa  atcatatgc  gttttaaaa  1980
tttttatat  tttgcaata  agtacattt  gactttgtt  gcataatgt  agtaacata  2040
atattccag  ggttttatg  acaggcaat  tagtcatta  gataataag  aaaacagtg  2100
tttagatga  agatcatta  tgcattttt  cctcatcaa  catatatct  ctttttttt  2160
ttttgcaat  ctctgtatt  tatgtcttt  aaaatttga  cttgacatt  aatgtcaca  2220
agttttgtt  ttttaaaaa  tgatttaaa  ttaagatcc  acatttttt  tattcttta  2280
gattttaca  ctaaaaaat  tctcctatc  caaaaataa  gtgggatcc  tatcagcat  2340
cccacagtt  atttctttg  tcttcacta  gcctgcata  tacagtcct  tgtagacat  2400
tgttccctt  ggtttccgt  ctttcttag  atggttgcc  acccacaat  tcattgatc  2460
gcagccaat  tgggtttgt  tggtttttt  aattcttaa  aacatcctc  agaggaata  2520
aaacaaatt  ttatgagca  aaccctata  aaagacaaa  tgaatttct  accttacca  2580
atataccat  aggccttgc  attgcttta  tgtagactc  tagttgaaa  tagtgcaga  2640
agaactcag  tgtactaga  tttcattgt  cattgatat  ctcagtatg  tgccacata  2700
gatgaattt  attatattc  accaaagca  tatactctt  catgatttc  aggccccat  2760
acccagtgt  tagagacat  aattctaac  agttgtttg  ttttaaatg  gtgatttca  2820
tttgggaaa  aggtttcaa  tgaatatat  tacatgggt  aaattactc  gtgctagtg  2880
agtcttact  gagaatgtt  atggtccca  ttgtatatg  aaatgtggt  agaatgtta  2940
ttggataat  tatatataa  aagttaaag  atgtaaagt  taacttcag  cacattttt  3000
gaacactgt  taacatttt  gcaaaacct  cttgtagga  aagagagct  tctacatga  3060
gatgacttg  tttatattt  agattttat  ttaaaagcc  tgtctgtta  acaagaaaa  3120
acacaaaag  actccagat  cctggttca  cattctgta  tcttactca  tttttcaag  3180
tatctattt  gttgcataa  ctaattgtt  actattcat  gaacagcaa  cgcctgttt  3240
ataaagaac  ttgaccaag  3259



<210> 3275
<211> 417
<212> PRT
<213> Homo sapiens
<308> P31323
<400> 3275

Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe Thr 
  1               5                  10                  15
Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala Leu 
             20                  25                  30
Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg Lys Gly Thr Ala 
         35                  40                  45
Arg Phe Gly His Glu Gly Arg Thr Trp Gly Asp Leu Gly Ala Ala Ala 
     50                  55                  60
Gly Gly Gly Thr Pro Ser Lys Gly Val Asn Phe Ala Glu Glu Pro Met 
 65                  70                  75                  80
Gln Ser Asp Ser Glu Asp Gly Glu Glu Glu Glu Ala Ala Pro Ala Asp 
                 85                  90                  95
Ala Gly Ala Phe Asn Ala Pro Val Ile Asn Arg Phe Thr Arg Arg Ala 
             100                105                110
Ser Val Cys Ala Glu Ala Tyr Asn Pro Asp Glu Glu Glu Asp Asp Ala 
         115                120                125
Glu Ser Arg Ile Ile His Pro Lys Thr Asp Asp Gln Arg Asn Arg Leu 
     130                135                140
Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Pro Glu 
 145                150                155                160
Gln Met Ser Gln Val Leu Asp Ala Met Phe Glu Lys Leu Val Lys Asp 
                 165                170                175
Gly Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr Val 
             180                185                190
Ile Asp Arg Gly Thr Phe Asp Ile Tyr Val Lys Cys Asp Gly Val Gly 
         195                200                205
Arg Cys Val Gly Asn Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu Ala 
     210                215                220
Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Thr Ala Thr Ser Pro 
 225                230                235                240
Gly Ala Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile Val 
                 245                250                255
Lys Asn Asn Ala Lys Lys Arg Lys Met Tyr Glu Ser Phe Ile Glu Ser 
             260                265                270
Leu Pro Phe Leu Lys Ser Leu Glu Phe Ser Glu Arg Leu Lys Val Val 
         275                280                285
Asp Val Ile Gly Thr Lys Val Tyr Asn Asp Gly Glu Gln Ile Ile Ala 
     290                295                300
Gln Gly Asp Ser Ala Asp Ser Phe Phe Ile Val Glu Ser Gly Glu Val 
 305                310                315                320
Lys Ile Thr Met Lys Arg Lys Gly Lys Ser Glu Val Glu Glu Asn Gly 
                 325                330                335
Ala Val Glu Met Pro Arg Cys Ser Arg Gly Gln Tyr Phe Gly Glu Leu 
             340                345                350
Ala Leu Val Thr Asn Lys Pro Arg Ala Ala Ser Ala His Ala Ile Gly 
         355                360                365
Thr Val Lys Cys Leu Ala Met Asp Val Gln Ala Phe Glu Arg Leu Leu 
     370                375                380
Gly Pro Cys Met Glu Ile Met Lys Arg Asn Ile Ala Thr Tyr Glu Glu 
 385                390                395                400
Gln Leu Val Ala Leu Phe Gly Thr Asn Met Asp Ile Val Glu Pro Thr 
                 405                410                415
Ala 
             420



<210> 3276
<211> 3108
<212> DNA
<213> Rattus norvegicus
<308> M12492
<400> 3276

tgagcatcg  gatccccgc  gggctcacg  agctgctgc  gggcttcac  gtggaggtg  60
tgaggcacc  gcccgccga  ctgctggag  tcgcgctgc  gcacttcac  cggctgcag  120
aggagaacg  gcgcaaggg  gccgcgcgc  tcggccatg  gggcaggac  tggggggac  180
cgggcgcag  cgccggggg  ggaaccccc  gtaagggtg  caacttcgc  gaggagccc  240
tgcgctccg  ttccgagaa  ggcgaagag  aggaggccg  ggaagcagg  gcgttcaac  300
ctccagtta  aaaccggtt  acaaggcgt  cctcggtat  tgcagaagc  tataatcct  360
atgaagaag  agatgatgc  gagtccagg  taatacatc  caaaactga  gatcaaaga  420
acagattgc  agaagcctg  aaagacatc  tgctgttta  gaacctgga  ccagaacag  480
tgtctcaag  attagatgc  atgtttgaa  aattggtca  agaagggga  cacgtaatc  540
atcaaggtg  tgatggtga  aacttttac  tcatcgaca  aggaacatt  gatatttat  600
taaaatgtg  tggcgttgg  agatgcgtt  gtaactatg  caatcgtgg  agttttgga  660
aactggcct  aatgtacaa  acacccaga  cagctacaa  cactgctac  tctcctggt  720
ctctgtggg  tttggacag  gtgaccttc  ggagaataa  agtaaaaaa  aatgccaaa  780
agaggaaga  gtacgagag  tttattgag  cactgccat  cctcaagtc  ctggaggtt  840
ctgaacgcc  gaaggtggt  gatgtgatt  gcaccaaag  ttacaacga  ggagaacag  900
tcattgctc  gggagactc  gcggattcg  tcttcattg  agaatctgg  gaagtgaga  960
ttactatga  gagaaaggg  aaatcagac  tcgaagaga  cggtgctgt  gaaatcgct  1020
ggtgtctcc  gggacagta  tttggagag  ttgccctgg  cactaacaa  ccaagagca  1080
catctgcac  cgccattgg  actgtcaaa  gcttagcca  ggatgtgca  gcatttgag  1140
ggcttctgg  accttgcat  gaaattatg  agaggaata  cgccaccta  gaggagcaa  1200
tagttgcac  gtttgggac  aacatggat  ttgttgagc  cactgcatg  agcaaaagt  1260
tggggaaga  agcgcgtta  tgaagcagt  acatagcag  ggttagtcc  ccgaggatg  1320
gttcgtgta  atcaagcat  ttctgtgac  tcaggtttt  cttttttaa  cagaaacca  1380
ttacaatat  tcagtgaac  gtagtgatt  aatagtagg  tttaacatc  ctttctaat  1440
ggtagttca  aaattaaca  aatcataaa  acgactttc  atttcataa  actgactga  1500
aggtttatt  aaatggtta  aatatattg  gagcataca  gtttaagaa  ataattaaa  1560
gatgtactc  taggccgac  tgtgtgttt  gattattca  gtatcgtgt  agtgactct  1620
cccctttac  agggaagct  gcacgtggc  tgtgcactc  cattctttt  ataactcgt  1680
agacagtaa  attgccaat  atttcattt  ctacctttt  tggcttagt  agttatgtg  1740
tagccttgg  ctatcggta  catggtgtg  aaatcatat  caattttaa  attttttat  1800
tttttgcaa  aaactacat  tcaacttct  tgacaactg  cagccagca  cctgggtag  1860
tgagtggct  ttggggcct  gtaatttag  tgttgtgat  attgggcag  gagcctttt  1920
ggatgaaag  tcataactg  gtctttcat  atcctttct  catcatcac  gcttcccgc  1980
ttgtattta  caacctcct  ggttcctta  agatcgcat  ttgacgttt  atgtcacaa  2040
ggttgtatt  gttctcaag  caatttcat  ttaatctga  aatttgttt  gtcctctaa  2100
agtcccgaa  cttctattc  gaaaaatga  agcttccct  tcaaaagac  tttgggatt  2160
ttagcccac  cccacagaa  atggctttg  tctgtaggt  ccagtgctg  gaccctgtg  2220
gtgtgtctg  ggtcccctg  ccttccctg  cctgagcac  agccagcga  cacattggt  2280
agcagccaa  caagtgcgt  tgccctttc  aaccttcaa  aacttcaac  acggtggtg  2340
aaagaagtc  gtgtataag  aaagccata  atgagtatt  atgggattt  tctctatcc  2400
acaccttat  aggccttgt  cttagcttt  aagtcagcc  acagttaaa  gtacacaaa  2460
tacaaaatt  tttttggtc  acaagatac  tacttttat  ccaaatacg  tgaattgtt  2520
aaaccaaag  aatatactt  tatgtgatt  tcaggcccc  tgaccaaat  tctaaaggc  2580
ttaattctc  ccagtttaa  tcatgttga  atgggtaat  ttactttgg  gaacatgtt  2640
ctaaggaac  gaggtatca  gtatgttaa  ttcatctgt  actgtctcg  tcttacaag  2700
gaatgttta  agtcctacg  gtacgctat  ctgttacct  cacctttag  cgtgctttt  2760
aaatgtcag  cttgcaaaa  ctttacgta  gaaaaaaag  tctctacat  aaggtaaca  2820
gttttctat  tcagagttc  gaagccatg  gttcaaaca  gaaacaaat  ccaaaaaca  2880
aaaaacaag  acaaaagcc  cccaaattc  tggctcatc  ttctgtgtt  ttttctctc  2940
tttccaagt  ctctttggt  gcattgcat  ggctgagtg  tgacgttca  ggaaaccaa  3000
gcctgtgga  taaagagcc  caaccaagg  tacagaggc  agctgtgtt  ttttcagta  3060
tgttggtta  atttaaatt  tccttataa  aaagcacac  tttataat  3108



<210> 3277
<211> 415
<212> PRT
<213> Rattus norvegicus
<308> P12369
<400> 3277

Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe Thr 
  1               5                  10                  15
Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala Leu 
             20                  25                  30
Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg Lys Gly Ala Ala 
         35                  40                  45
Arg Phe Gly His Glu Gly Arg Thr Trp Gly Asp Ala Gly Ala Ala Ala 
     50                  55                  60
Gly Gly Gly Thr Pro Ser Lys Gly Val Asn Phe Ala Glu Glu Pro Met 
 65                  70                  75                  80
Arg Ser Asp Ser Glu Asn Gly Glu Glu Glu Glu Ala Ala Glu Ala Gly 
                 85                  90                  95
Ala Phe Asn Ala Pro Val Ile Asn Arg Phe Thr Arg Arg Ala Ser Val 
             100                105                110
Cys Ala Glu Ala Tyr Asn Pro Asp Glu Glu Glu Asp Asp Ala Glu Ser 
         115                120                125
Arg Ile Ile His Pro Lys Thr Asp Asp Gln Arg Asn Arg Leu Gln Glu 
     130                135                140
Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Pro Glu Gln Met 
 145                150                155                160
Ser Gln Val Leu Asp Ala Met Phe Glu Lys Leu Val Lys Glu Gly Glu 
                 165                170                175
His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr Val Ile Asp 
             180                185                190
Arg Gly Thr Phe Asp Ile Tyr Val Lys Cys Asp Gly Val Gly Arg Cys 
         195                200                205
Val Gly Asn Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu Ala Leu Met 
     210                215                220
Tyr Asn Thr Pro Arg Ala Ala Thr Ile Thr Ala Thr Ser Pro Gly Ala 
 225                230                235                240
Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile Val Lys Asn 
                 245                250                255
Asn Ala Lys Lys Arg Lys Met Tyr Glu Ser Phe Ile Glu Ser Leu Pro 
             260                265                270
Phe Leu Lys Ser Leu Glu Val Ser Glu Arg Leu Lys Val Val Asp Val 
         275                280                285
Ile Gly Thr Lys Val Tyr Asn Asp Gly Glu Gln Ile Ile Ala Gln Gly 
     290                295                300
Asp Ser Ala Asp Ser Phe Phe Ile Val Glu Ser Gly Glu Val Arg Ile 
 305                310                315                320
Thr Met Lys Arg Lys Gly Lys Ser Asp Ile Glu Glu Asn Gly Ala Val 
                 325                330                335
Glu Ile Ala Arg Cys Leu Arg Gly Gln Tyr Phe Gly Glu Leu Ala Leu 
             340                345                350
Val Thr Asn Lys Pro Arg Ala Ala Ser Ala His Ala Ile Gly Thr Val 
         355                360                365
Lys Cys Leu Ala Met Asp Val Gln Ala Phe Glu Arg Leu Leu Gly Pro 
     370                375                380
Cys Met Glu Ile Met Lys Arg Asn Ile Ala Thr Tyr Glu Glu Gln Leu 
 385                390                395                400
Val Ala Leu Phe Gly Thr Asn Met Asp Ile Val Glu Pro Thr Ala 
                 405                410                415



<210> 3278
<211> 3259
<212> DNA
<213> Homo sapiens
<308> M31158
<400> 3278

gacgcgcgc  gggagccgg  ggccgggcc  gccggcgcc  gggcccagt  cgccgcgct  60
gcagccggt  gcgcgccag  cgtaggcgt  gctcggcag  cgcggggcc  taggcgtgc  120
ggggagggg  cgagggcgg  caggcgcct  ccgccccgg  ggcaggatg  gcatcgaga  180
cccggcggg  ctgacggag  tgctgcagg  cttcacggt  gaggtgctg  ggcaccagc  240
cgcggacct  ctggagttc  cgctgcagc  cttcacccg  ctgcagcag  agaacgagc  300
caaaggcac  gcgcgcttc  gccatgagg  caggacctg  ggggacctg  gcgccgctg  360
cgggggcgg  acccccagc  agggggtca  cttcgccga  gagcccatg  agtccgact  420
cgaggacgg  gaggaggag  aggcggcgc  cgcggacgc  ggggcgttc  atgctccag  480
aataaaccg  ttcacaagg  gtgcctcag  atgtgcaga  gcttataat  ctgatgaag  540
agaagatga  gcagagtcc  ggattatac  tccaaaaac  gatgatcaa  gaaataggt  600
gcaagaggc  tgcaaagac  tcctgctgt  taagaatct  gatccggag  agatgtctc  660
agtattaga  gccatgttt  aaaaattgg  caaagatgg  gagcatgta  ttgatcaag  720
tgacgatgg  gacaacttt  atgtaattg  tagaggcac  tttgatatt  atgtgaaat  780
tgatggtgt  ggaagatgt  ttggtaact  tgataatcg  gggagtttc  gcgaactgg  840
cttaatgta  aatacaccc  gagcagcta  aatcactgc  acctctcct  gtgctctgt  900
gggtttgga  agggtaacc  tcaggagaa  aattgtgaa  aacaatgcc  aaaagagaa  960
aatgtatga  agctttatt  agtcactgc  attccttaa  tctttggag  tttctgaac  1020
cctgaaagt  gtagatgtg  taggcacca  agtatacaa  gatggagaa  aaatcattg  1080
tcagggaga  tcggctgat  cttttttca  tgtagaatc  ggagaagtg  aaattacta  1140
gaaaagaaa  ggtaaatca  aagtggaag  gaatggtgc  gtagaaatg  ctcgatgct  1200
gcggggaca  tactttgga  agcttgccc  ggtaactaa  aaacctcga  cagcttctg  1260
ccacgccat  gggactgtc  aatgtttag  aatggatgt  caagcattt  aaaggcttc  1320
gggaccttg  atggaaatt  tgaaaagga  catcgctac  tatgaagaa  agttagttg  1380
cctgtttgg  acgaacatg  atattgttg  acccactgc  tgaagcaaa  gtatggagc  1440
agacctgta  tgacaaaat  acacagtag  ggttagtcc  ctgagaatg  gtttgtgta  1500
atgccaagc  ttttctgtg  tttcaggtt  tttcctttt  ttacattta  aacgtatca  1560
taaacagta  tgatttaat  gtcaatagg  tttaacatc  ctttctaaa  agtagttca  1620
aaaaaaatc  acatactga  aaaatgact  tgtactcca  aaaattatg  ctgaaaggt  1680
tattaaaat  attgtaata  atagaaagt  tctgtgttt  agaagataa  taaaggatg  1740
tatcatagg  tatatgtgt  ttacttatt  agactgata  tcatattag  gactatccc  1800
atgtaagag  gcacttggc  attaaacat  ctacacagc  tggcatcac  tttttttat  1860
actcattaa  cacagtaaa  ttttaatca  ttttgtttt  aagttttct  gcttgataa  1920
ttatgtgct  ccttggcct  ttggtgaaa  ggtataaaa  atcatatgc  gttttaaaa  1980
tttttatat  tttgcaata  agtacattt  gactttgtt  gcataatgt  agtaacata  2040
atattccag  ggttttatg  acaggcaat  tagtcatta  gataataag  aaaacagtg  2100
tttagatga  agatcatta  tgcattttt  cctcatcaa  catatatct  ctttttttt  2160
ttttgcaat  ctctgtatt  tatgtcttt  aaaatttga  cttgacatt  aatgtcaca  2220
agttttgtt  ttttaaaaa  tgatttaaa  ttaagatcc  acatttttt  tattcttta  2280
gattttaca  ctaaaaaat  tctcctatc  caaaaataa  gtgggatcc  tatcagcat  2340
cccacagtt  atttctttg  tcttcacta  gcctgcata  tacagtcct  tgtagacat  2400
tgttccctt  ggtttccgt  ctttcttag  atggttgcc  acccacaat  tcattgatc  2460
gcagccaat  tgggtttgt  tggtttttt  aattcttaa  aacatcctc  agaggaata  2520
aaacaaatt  ttatgagca  aaccctata  aaagacaaa  tgaatttct  accttacca  2580
atataccat  aggccttgc  attgcttta  tgtagactc  tagttgaaa  tagtgcaga  2640
agaactcag  tgtactaga  tttcattgt  cattgatat  ctcagtatg  tgccacata  2700
gatgaattt  attatattc  accaaagca  tatactctt  catgatttc  aggccccat  2760
acccagtgt  tagagacat  aattctaac  agttgtttg  ttttaaatg  gtgatttca  2820
tttgggaaa  aggtttcaa  tgaatatat  tacatgggt  aaattactc  gtgctagtg  2880
agtcttact  gagaatgtt  atggtccca  ttgtatatg  aaatgtggt  agaatgtta  2940
ttggataat  tatatataa  aagttaaag  atgtaaagt  taacttcag  cacattttt  3000
gaacactgt  taacatttt  gcaaaacct  cttgtagga  aagagagct  tctacatga  3060
gatgacttg  tttatattt  agattttat  ttaaaagcc  tgtctgtta  acaagaaaa  3120
acacaaaag  actccagat  cctggttca  cattctgta  tcttactca  tttttcaag  3180
tatctattt  gttgcataa  ctaattgtt  actattcat  gaacagcaa  cgcctgttt  3240
ataaagaac  ttgaccaag  3259



<210> 3279
<211> 417
<212> PRT
<213> Homo sapiens
<308> P31323
<400> 3279

Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe Thr 
  1               5                  10                  15
Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala Leu 
             20                  25                  30
Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg Lys Gly Thr Ala 
         35                  40                  45
Arg Phe Gly His Glu Gly Arg Thr Trp Gly Asp Leu Gly Ala Ala Ala 
     50                  55                  60
Gly Gly Gly Thr Pro Ser Lys Gly Val Asn Phe Ala Glu Glu Pro Met 
 65                  70                  75                  80
Gln Ser Asp Ser Glu Asp Gly Glu Glu Glu Glu Ala Ala Pro Ala Asp 
                 85                  90                  95
Ala Gly Ala Phe Asn Ala Pro Val Ile Asn Arg Phe Thr Arg Arg Ala 
             100                105                110
Ser Val Cys Ala Glu Ala Tyr Asn Pro Asp Glu Glu Glu Asp Asp Ala 
         115                120                125
Glu Ser Arg Ile Ile His Pro Lys Thr Asp Asp Gln Arg Asn Arg Leu 
     130                135                140
Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Pro Glu 
 145                150                155                160
Gln Met Ser Gln Val Leu Asp Ala Met Phe Glu Lys Leu Val Lys Asp 
                 165                170                175
Gly Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr Val 
             180                185                190
Ile Asp Arg Gly Thr Phe Asp Ile Tyr Val Lys Cys Asp Gly Val Gly 
         195                200                205
Arg Cys Val Gly Asn Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu Ala 
     210                215                220
Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Thr Ala Thr Ser Pro 
 225                230                235                240
Gly Ala Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile Val 
                 245                250                255
Lys Asn Asn Ala Lys Lys Arg Lys Met Tyr Glu Ser Phe Ile Glu Ser 
             260                265                270
Leu Pro Phe Leu Lys Ser Leu Glu Phe Ser Glu Arg Leu Lys Val Val 
         275                280                285
Asp Val Ile Gly Thr Lys Val Tyr Asn Asp Gly Glu Gln Ile Ile Ala 
     290                295                300
Gln Gly Asp Ser Ala Asp Ser Phe Phe Ile Val Glu Ser Gly Glu Val 
 305                310                315                320
Lys Ile Thr Met Lys Arg Lys Gly Lys Ser Glu Val Glu Glu Asn Gly 
                 325                330                335
Ala Val Glu Met Pro Arg Cys Ser Arg Gly Gln Tyr Phe Gly Glu Leu 
             340                345                350
Ala Leu Val Thr Asn Lys Pro Arg Ala Ala Ser Ala His Ala Ile Gly 
         355                360                365
Thr Val Lys Cys Leu Ala Met Asp Val Gln Ala Phe Glu Arg Leu Leu 
     370                375                380
Gly Pro Cys Met Glu Ile Met Lys Arg Asn Ile Ala Thr Tyr Glu Glu 
 385                390                395                400
Gln Leu Val Ala Leu Phe Gly Thr Asn Met Asp Ile Val Glu Pro Thr 
                 405                410                415
Ala 
             420



<210> 3280
<211> 3108
<212> DNA
<213> Rattus norvegicus
<308> M12492
<400> 3280

tgagcatcg  gatccccgc  gggctcacg  agctgctgc  gggcttcac  gtggaggtg  60
tgaggcacc  gcccgccga  ctgctggag  tcgcgctgc  gcacttcac  cggctgcag  120
aggagaacg  gcgcaaggg  gccgcgcgc  tcggccatg  gggcaggac  tggggggac  180
cgggcgcag  cgccggggg  ggaaccccc  gtaagggtg  caacttcgc  gaggagccc  240
tgcgctccg  ttccgagaa  ggcgaagag  aggaggccg  ggaagcagg  gcgttcaac  300
ctccagtta  aaaccggtt  acaaggcgt  cctcggtat  tgcagaagc  tataatcct  360
atgaagaag  agatgatgc  gagtccagg  taatacatc  caaaactga  gatcaaaga  420
acagattgc  agaagcctg  aaagacatc  tgctgttta  gaacctgga  ccagaacag  480
tgtctcaag  attagatgc  atgtttgaa  aattggtca  agaagggga  cacgtaatc  540
atcaaggtg  tgatggtga  aacttttac  tcatcgaca  aggaacatt  gatatttat  600
taaaatgtg  tggcgttgg  agatgcgtt  gtaactatg  caatcgtgg  agttttgga  660
aactggcct  aatgtacaa  acacccaga  cagctacaa  cactgctac  tctcctggt  720
ctctgtggg  tttggacag  gtgaccttc  ggagaataa  agtaaaaaa  aatgccaaa  780
agaggaaga  gtacgagag  tttattgag  cactgccat  cctcaagtc  ctggaggtt  840
ctgaacgcc  gaaggtggt  gatgtgatt  gcaccaaag  ttacaacga  ggagaacag  900
tcattgctc  gggagactc  gcggattcg  tcttcattg  agaatctgg  gaagtgaga  960
ttactatga  gagaaaggg  aaatcagac  tcgaagaga  cggtgctgt  gaaatcgct  1020
ggtgtctcc  gggacagta  tttggagag  ttgccctgg  cactaacaa  ccaagagca  1080
catctgcac  cgccattgg  actgtcaaa  gcttagcca  ggatgtgca  gcatttgag  1140
ggcttctgg  accttgcat  gaaattatg  agaggaata  cgccaccta  gaggagcaa  1200
tagttgcac  gtttgggac  aacatggat  ttgttgagc  cactgcatg  agcaaaagt  1260
tggggaaga  agcgcgtta  tgaagcagt  acatagcag  ggttagtcc  ccgaggatg  1320
gttcgtgta  atcaagcat  ttctgtgac  tcaggtttt  cttttttaa  cagaaacca  1380
ttacaatat  tcagtgaac  gtagtgatt  aatagtagg  tttaacatc  ctttctaat  1440
ggtagttca  aaattaaca  aatcataaa  acgactttc  atttcataa  actgactga  1500
aggtttatt  aaatggtta  aatatattg  gagcataca  gtttaagaa  ataattaaa  1560
gatgtactc  taggccgac  tgtgtgttt  gattattca  gtatcgtgt  agtgactct  1620
cccctttac  agggaagct  gcacgtggc  tgtgcactc  cattctttt  ataactcgt  1680
agacagtaa  attgccaat  atttcattt  ctacctttt  tggcttagt  agttatgtg  1740
tagccttgg  ctatcggta  catggtgtg  aaatcatat  caattttaa  attttttat  1800
tttttgcaa  aaactacat  tcaacttct  tgacaactg  cagccagca  cctgggtag  1860
tgagtggct  ttggggcct  gtaatttag  tgttgtgat  attgggcag  gagcctttt  1920
ggatgaaag  tcataactg  gtctttcat  atcctttct  catcatcac  gcttcccgc  1980
ttgtattta  caacctcct  ggttcctta  agatcgcat  ttgacgttt  atgtcacaa  2040
ggttgtatt  gttctcaag  caatttcat  ttaatctga  aatttgttt  gtcctctaa  2100
agtcccgaa  cttctattc  gaaaaatga  agcttccct  tcaaaagac  tttgggatt  2160
ttagcccac  cccacagaa  atggctttg  tctgtaggt  ccagtgctg  gaccctgtg  2220
gtgtgtctg  ggtcccctg  ccttccctg  cctgagcac  agccagcga  cacattggt  2280
agcagccaa  caagtgcgt  tgccctttc  aaccttcaa  aacttcaac  acggtggtg  2340
aaagaagtc  gtgtataag  aaagccata  atgagtatt  atgggattt  tctctatcc  2400
acaccttat  aggccttgt  cttagcttt  aagtcagcc  acagttaaa  gtacacaaa  2460
tacaaaatt  tttttggtc  acaagatac  tacttttat  ccaaatacg  tgaattgtt  2520
aaaccaaag  aatatactt  tatgtgatt  tcaggcccc  tgaccaaat  tctaaaggc  2580
ttaattctc  ccagtttaa  tcatgttga  atgggtaat  ttactttgg  gaacatgtt  2640
ctaaggaac  gaggtatca  gtatgttaa  ttcatctgt  actgtctcg  tcttacaag  2700
gaatgttta  agtcctacg  gtacgctat  ctgttacct  cacctttag  cgtgctttt  2760
aaatgtcag  cttgcaaaa  ctttacgta  gaaaaaaag  tctctacat  aaggtaaca  2820
gttttctat  tcagagttc  gaagccatg  gttcaaaca  gaaacaaat  ccaaaaaca  2880
aaaaacaag  acaaaagcc  cccaaattc  tggctcatc  ttctgtgtt  ttttctctc  2940
tttccaagt  ctctttggt  gcattgcat  ggctgagtg  tgacgttca  ggaaaccaa  3000
gcctgtgga  taaagagcc  caaccaagg  tacagaggc  agctgtgtt  ttttcagta  3060
tgttggtta  atttaaatt  tccttataa  aaagcacac  tttataat  3108



<210> 3281
<211> 415
<212> PRT
<213> Rattus norvegicus
<308> P12369
<400> 3281

Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe Thr 
  1               5                  10                  15
Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala Leu 
             20                  25                  30
Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg Lys Gly Ala Ala 
         35                  40                  45
Arg Phe Gly His Glu Gly Arg Thr Trp Gly Asp Ala Gly Ala Ala Ala 
     50                  55                  60
Gly Gly Gly Thr Pro Ser Lys Gly Val Asn Phe Ala Glu Glu Pro Met 
 65                  70                  75                  80
Arg Ser Asp Ser Glu Asn Gly Glu Glu Glu Glu Ala Ala Glu Ala Gly 
                 85                  90                  95
Ala Phe Asn Ala Pro Val Ile Asn Arg Phe Thr Arg Arg Ala Ser Val 
             100                105                110
Cys Ala Glu Ala Tyr Asn Pro Asp Glu Glu Glu Asp Asp Ala Glu Ser 
         115                120                125
Arg Ile Ile His Pro Lys Thr Asp Asp Gln Arg Asn Arg Leu Gln Glu 
     130                135                140
Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Pro Glu Gln Met 
 145                150                155                160
Ser Gln Val Leu Asp Ala Met Phe Glu Lys Leu Val Lys Glu Gly Glu 
                 165                170                175
His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr Val Ile Asp 
             180                185                190
Arg Gly Thr Phe Asp Ile Tyr Val Lys Cys Asp Gly Val Gly Arg Cys 
         195                200                205
Val Gly Asn Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu Ala Leu Met 
     210                215                220
Tyr Asn Thr Pro Arg Ala Ala Thr Ile Thr Ala Thr Ser Pro Gly Ala 
 225                230                235                240
Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile Val Lys Asn 
                 245                250                255
Asn Ala Lys Lys Arg Lys Met Tyr Glu Ser Phe Ile Glu Ser Leu Pro 
             260                265                270
Phe Leu Lys Ser Leu Glu Val Ser Glu Arg Leu Lys Val Val Asp Val 
         275                280                285
Ile Gly Thr Lys Val Tyr Asn Asp Gly Glu Gln Ile Ile Ala Gln Gly 
     290                295                300
Asp Ser Ala Asp Ser Phe Phe Ile Val Glu Ser Gly Glu Val Arg Ile 
 305                310                315                320
Thr Met Lys Arg Lys Gly Lys Ser Asp Ile Glu Glu Asn Gly Ala Val 
                 325                330                335
Glu Ile Ala Arg Cys Leu Arg Gly Gln Tyr Phe Gly Glu Leu Ala Leu 
             340                345                350
Val Thr Asn Lys Pro Arg Ala Ala Ser Ala His Ala Ile Gly Thr Val 
         355                360                365
Lys Cys Leu Ala Met Asp Val Gln Ala Phe Glu Arg Leu Leu Gly Pro 
     370                375                380
Cys Met Glu Ile Met Lys Arg Asn Ile Ala Thr Tyr Glu Glu Gln Leu 
 385                390                395                400
Val Ala Leu Phe Gly Thr Asn Met Asp Ile Val Glu Pro Thr Ala 
                 405                410                415



<210> 3282
<211> 3259
<212> DNA
<213> Homo sapiens
<308> M31158
<400> 3282

gacgcgcgc  gggagccgg  ggccgggcc  gccggcgcc  gggcccagt  cgccgcgct  60
gcagccggt  gcgcgccag  cgtaggcgt  gctcggcag  cgcggggcc  taggcgtgc  120
ggggagggg  cgagggcgg  caggcgcct  ccgccccgg  ggcaggatg  gcatcgaga  180
cccggcggg  ctgacggag  tgctgcagg  cttcacggt  gaggtgctg  ggcaccagc  240
cgcggacct  ctggagttc  cgctgcagc  cttcacccg  ctgcagcag  agaacgagc  300
caaaggcac  gcgcgcttc  gccatgagg  caggacctg  ggggacctg  gcgccgctg  360
cgggggcgg  acccccagc  agggggtca  cttcgccga  gagcccatg  agtccgact  420
cgaggacgg  gaggaggag  aggcggcgc  cgcggacgc  ggggcgttc  atgctccag  480
aataaaccg  ttcacaagg  gtgcctcag  atgtgcaga  gcttataat  ctgatgaag  540
agaagatga  gcagagtcc  ggattatac  tccaaaaac  gatgatcaa  gaaataggt  600
gcaagaggc  tgcaaagac  tcctgctgt  taagaatct  gatccggag  agatgtctc  660
agtattaga  gccatgttt  aaaaattgg  caaagatgg  gagcatgta  ttgatcaag  720
tgacgatgg  gacaacttt  atgtaattg  tagaggcac  tttgatatt  atgtgaaat  780
tgatggtgt  ggaagatgt  ttggtaact  tgataatcg  gggagtttc  gcgaactgg  840
cttaatgta  aatacaccc  gagcagcta  aatcactgc  acctctcct  gtgctctgt  900
gggtttgga  agggtaacc  tcaggagaa  aattgtgaa  aacaatgcc  aaaagagaa  960
aatgtatga  agctttatt  agtcactgc  attccttaa  tctttggag  tttctgaac  1020
cctgaaagt  gtagatgtg  taggcacca  agtatacaa  gatggagaa  aaatcattg  1080
tcagggaga  tcggctgat  cttttttca  tgtagaatc  ggagaagtg  aaattacta  1140
gaaaagaaa  ggtaaatca  aagtggaag  gaatggtgc  gtagaaatg  ctcgatgct  1200
gcggggaca  tactttgga  agcttgccc  ggtaactaa  aaacctcga  cagcttctg  1260
ccacgccat  gggactgtc  aatgtttag  aatggatgt  caagcattt  aaaggcttc  1320
gggaccttg  atggaaatt  tgaaaagga  catcgctac  tatgaagaa  agttagttg  1380
cctgtttgg  acgaacatg  atattgttg  acccactgc  tgaagcaaa  gtatggagc  1440
agacctgta  tgacaaaat  acacagtag  ggttagtcc  ctgagaatg  gtttgtgta  1500
atgccaagc  ttttctgtg  tttcaggtt  tttcctttt  ttacattta  aacgtatca  1560
taaacagta  tgatttaat  gtcaatagg  tttaacatc  ctttctaaa  agtagttca  1620
aaaaaaatc  acatactga  aaaatgact  tgtactcca  aaaattatg  ctgaaaggt  1680
tattaaaat  attgtaata  atagaaagt  tctgtgttt  agaagataa  taaaggatg  1740
tatcatagg  tatatgtgt  ttacttatt  agactgata  tcatattag  gactatccc  1800
atgtaagag  gcacttggc  attaaacat  ctacacagc  tggcatcac  tttttttat  1860
actcattaa  cacagtaaa  ttttaatca  ttttgtttt  aagttttct  gcttgataa  1920
ttatgtgct  ccttggcct  ttggtgaaa  ggtataaaa  atcatatgc  gttttaaaa  1980
tttttatat  tttgcaata  agtacattt  gactttgtt  gcataatgt  agtaacata  2040
atattccag  ggttttatg  acaggcaat  tagtcatta  gataataag  aaaacagtg  2100
tttagatga  agatcatta  tgcattttt  cctcatcaa  catatatct  ctttttttt  2160
ttttgcaat  ctctgtatt  tatgtcttt  aaaatttga  cttgacatt  aatgtcaca  2220
agttttgtt  ttttaaaaa  tgatttaaa  ttaagatcc  acatttttt  tattcttta  2280
gattttaca  ctaaaaaat  tctcctatc  caaaaataa  gtgggatcc  tatcagcat  2340
cccacagtt  atttctttg  tcttcacta  gcctgcata  tacagtcct  tgtagacat  2400
tgttccctt  ggtttccgt  ctttcttag  atggttgcc  acccacaat  tcattgatc  2460
gcagccaat  tgggtttgt  tggtttttt  aattcttaa  aacatcctc  agaggaata  2520
aaacaaatt  ttatgagca  aaccctata  aaagacaaa  tgaatttct  accttacca  2580
atataccat  aggccttgc  attgcttta  tgtagactc  tagttgaaa  tagtgcaga  2640
agaactcag  tgtactaga  tttcattgt  cattgatat  ctcagtatg  tgccacata  2700
gatgaattt  attatattc  accaaagca  tatactctt  catgatttc  aggccccat  2760
acccagtgt  tagagacat  aattctaac  agttgtttg  ttttaaatg  gtgatttca  2820
tttgggaaa  aggtttcaa  tgaatatat  tacatgggt  aaattactc  gtgctagtg  2880
agtcttact  gagaatgtt  atggtccca  ttgtatatg  aaatgtggt  agaatgtta  2940
ttggataat  tatatataa  aagttaaag  atgtaaagt  taacttcag  cacattttt  3000
gaacactgt  taacatttt  gcaaaacct  cttgtagga  aagagagct  tctacatga  3060
gatgacttg  tttatattt  agattttat  ttaaaagcc  tgtctgtta  acaagaaaa  3120
acacaaaag  actccagat  cctggttca  cattctgta  tcttactca  tttttcaag  3180
tatctattt  gttgcataa  ctaattgtt  actattcat  gaacagcaa  cgcctgttt  3240
ataaagaac  ttgaccaag  3259



<210> 3283
<211> 417
<212> PRT
<213> Homo sapiens
<308> P31323
<400> 3283

Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe Thr 
  1               5                  10                  15
Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala Leu 
             20                  25                  30
Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg Lys Gly Thr Ala 
         35                  40                  45
Arg Phe Gly His Glu Gly Arg Thr Trp Gly Asp Leu Gly Ala Ala Ala 
     50                  55                  60
Gly Gly Gly Thr Pro Ser Lys Gly Val Asn Phe Ala Glu Glu Pro Met 
 65                  70                  75                  80
Gln Ser Asp Ser Glu Asp Gly Glu Glu Glu Glu Ala Ala Pro Ala Asp 
                 85                  90                  95
Ala Gly Ala Phe Asn Ala Pro Val Ile Asn Arg Phe Thr Arg Arg Ala 
             100                105                110
Ser Val Cys Ala Glu Ala Tyr Asn Pro Asp Glu Glu Glu Asp Asp Ala 
         115                120                125
Glu Ser Arg Ile Ile His Pro Lys Thr Asp Asp Gln Arg Asn Arg Leu 
     130                135                140
Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Pro Glu 
 145                150                155                160
Gln Met Ser Gln Val Leu Asp Ala Met Phe Glu Lys Leu Val Lys Asp 
                 165                170                175
Gly Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr Val 
             180                185                190
Ile Asp Arg Gly Thr Phe Asp Ile Tyr Val Lys Cys Asp Gly Val Gly 
         195                200                205
Arg Cys Val Gly Asn Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu Ala 
     210                215                220
Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Thr Ala Thr Ser Pro 
 225                230                235                240
Gly Ala Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile Val 
                 245                250                255
Lys Asn Asn Ala Lys Lys Arg Lys Met Tyr Glu Ser Phe Ile Glu Ser 
             260                265                270
Leu Pro Phe Leu Lys Ser Leu Glu Phe Ser Glu Arg Leu Lys Val Val 
         275                280                285
Asp Val Ile Gly Thr Lys Val Tyr Asn Asp Gly Glu Gln Ile Ile Ala 
     290                295                300
Gln Gly Asp Ser Ala Asp Ser Phe Phe Ile Val Glu Ser Gly Glu Val 
 305                310                315                320
Lys Ile Thr Met Lys Arg Lys Gly Lys Ser Glu Val Glu Glu Asn Gly 
                 325                330                335
Ala Val Glu Met Pro Arg Cys Ser Arg Gly Gln Tyr Phe Gly Glu Leu 
             340                345                350
Ala Leu Val Thr Asn Lys Pro Arg Ala Ala Ser Ala His Ala Ile Gly 
         355                360                365
Thr Val Lys Cys Leu Ala Met Asp Val Gln Ala Phe Glu Arg Leu Leu 
     370                375                380
Gly Pro Cys Met Glu Ile Met Lys Arg Asn Ile Ala Thr Tyr Glu Glu 
 385                390                395                400
Gln Leu Val Ala Leu Phe Gly Thr Asn Met Asp Ile Val Glu Pro Thr 
                 405                410                415
Ala 
             420



<210> 3284
<211> 3108
<212> DNA
<213> Rattus norvegicus
<308> M12492
<400> 3284

tgagcatcg  gatccccgc  gggctcacg  agctgctgc  gggcttcac  gtggaggtg  60
tgaggcacc  gcccgccga  ctgctggag  tcgcgctgc  gcacttcac  cggctgcag  120
aggagaacg  gcgcaaggg  gccgcgcgc  tcggccatg  gggcaggac  tggggggac  180
cgggcgcag  cgccggggg  ggaaccccc  gtaagggtg  caacttcgc  gaggagccc  240
tgcgctccg  ttccgagaa  ggcgaagag  aggaggccg  ggaagcagg  gcgttcaac  300
ctccagtta  aaaccggtt  acaaggcgt  cctcggtat  tgcagaagc  tataatcct  360
atgaagaag  agatgatgc  gagtccagg  taatacatc  caaaactga  gatcaaaga  420
acagattgc  agaagcctg  aaagacatc  tgctgttta  gaacctgga  ccagaacag  480
tgtctcaag  attagatgc  atgtttgaa  aattggtca  agaagggga  cacgtaatc  540
atcaaggtg  tgatggtga  aacttttac  tcatcgaca  aggaacatt  gatatttat  600
taaaatgtg  tggcgttgg  agatgcgtt  gtaactatg  caatcgtgg  agttttgga  660
aactggcct  aatgtacaa  acacccaga  cagctacaa  cactgctac  tctcctggt  720
ctctgtggg  tttggacag  gtgaccttc  ggagaataa  agtaaaaaa  aatgccaaa  780
agaggaaga  gtacgagag  tttattgag  cactgccat  cctcaagtc  ctggaggtt  840
ctgaacgcc  gaaggtggt  gatgtgatt  gcaccaaag  ttacaacga  ggagaacag  900
tcattgctc  gggagactc  gcggattcg  tcttcattg  agaatctgg  gaagtgaga  960
ttactatga  gagaaaggg  aaatcagac  tcgaagaga  cggtgctgt  gaaatcgct  1020
ggtgtctcc  gggacagta  tttggagag  ttgccctgg  cactaacaa  ccaagagca  1080
catctgcac  cgccattgg  actgtcaaa  gcttagcca  ggatgtgca  gcatttgag  1140
ggcttctgg  accttgcat  gaaattatg  agaggaata  cgccaccta  gaggagcaa  1200
tagttgcac  gtttgggac  aacatggat  ttgttgagc  cactgcatg  agcaaaagt  1260
tggggaaga  agcgcgtta  tgaagcagt  acatagcag  ggttagtcc  ccgaggatg  1320
gttcgtgta  atcaagcat  ttctgtgac  tcaggtttt  cttttttaa  cagaaacca  1380
ttacaatat  tcagtgaac  gtagtgatt  aatagtagg  tttaacatc  ctttctaat  1440
ggtagttca  aaattaaca  aatcataaa  acgactttc  atttcataa  actgactga  1500
aggtttatt  aaatggtta  aatatattg  gagcataca  gtttaagaa  ataattaaa  1560
gatgtactc  taggccgac  tgtgtgttt  gattattca  gtatcgtgt  agtgactct  1620
cccctttac  agggaagct  gcacgtggc  tgtgcactc  cattctttt  ataactcgt  1680
agacagtaa  attgccaat  atttcattt  ctacctttt  tggcttagt  agttatgtg  1740
tagccttgg  ctatcggta  catggtgtg  aaatcatat  caattttaa  attttttat  1800
tttttgcaa  aaactacat  tcaacttct  tgacaactg  cagccagca  cctgggtag  1860
tgagtggct  ttggggcct  gtaatttag  tgttgtgat  attgggcag  gagcctttt  1920
ggatgaaag  tcataactg  gtctttcat  atcctttct  catcatcac  gcttcccgc  1980
ttgtattta  caacctcct  ggttcctta  agatcgcat  ttgacgttt  atgtcacaa  2040
ggttgtatt  gttctcaag  caatttcat  ttaatctga  aatttgttt  gtcctctaa  2100
agtcccgaa  cttctattc  gaaaaatga  agcttccct  tcaaaagac  tttgggatt  2160
ttagcccac  cccacagaa  atggctttg  tctgtaggt  ccagtgctg  gaccctgtg  2220
gtgtgtctg  ggtcccctg  ccttccctg  cctgagcac  agccagcga  cacattggt  2280
agcagccaa  caagtgcgt  tgccctttc  aaccttcaa  aacttcaac  acggtggtg  2340
aaagaagtc  gtgtataag  aaagccata  atgagtatt  atgggattt  tctctatcc  2400
acaccttat  aggccttgt  cttagcttt  aagtcagcc  acagttaaa  gtacacaaa  2460
tacaaaatt  tttttggtc  acaagatac  tacttttat  ccaaatacg  tgaattgtt  2520
aaaccaaag  aatatactt  tatgtgatt  tcaggcccc  tgaccaaat  tctaaaggc  2580
ttaattctc  ccagtttaa  tcatgttga  atgggtaat  ttactttgg  gaacatgtt  2640
ctaaggaac  gaggtatca  gtatgttaa  ttcatctgt  actgtctcg  tcttacaag  2700
gaatgttta  agtcctacg  gtacgctat  ctgttacct  cacctttag  cgtgctttt  2760
aaatgtcag  cttgcaaaa  ctttacgta  gaaaaaaag  tctctacat  aaggtaaca  2820
gttttctat  tcagagttc  gaagccatg  gttcaaaca  gaaacaaat  ccaaaaaca  2880
aaaaacaag  acaaaagcc  cccaaattc  tggctcatc  ttctgtgtt  ttttctctc  2940
tttccaagt  ctctttggt  gcattgcat  ggctgagtg  tgacgttca  ggaaaccaa  3000
gcctgtgga  taaagagcc  caaccaagg  tacagaggc  agctgtgtt  ttttcagta  3060
tgttggtta  atttaaatt  tccttataa  aaagcacac  tttataat  3108



<210> 3285
<211> 415
<212> PRT
<213> Rattus norvegicus
<308> P12369
<400> 3285

Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe Thr 
  1               5                  10                  15
Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala Leu 
             20                  25                  30
Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg Lys Gly Ala Ala 
         35                  40                  45
Arg Phe Gly His Glu Gly Arg Thr Trp Gly Asp Ala Gly Ala Ala Ala 
     50                  55                  60
Gly Gly Gly Thr Pro Ser Lys Gly Val Asn Phe Ala Glu Glu Pro Met 
 65                  70                  75                  80
Arg Ser Asp Ser Glu Asn Gly Glu Glu Glu Glu Ala Ala Glu Ala Gly 
                 85                  90                  95
Ala Phe Asn Ala Pro Val Ile Asn Arg Phe Thr Arg Arg Ala Ser Val 
             100                105                110
Cys Ala Glu Ala Tyr Asn Pro Asp Glu Glu Glu Asp Asp Ala Glu Ser 
         115                120                125
Arg Ile Ile His Pro Lys Thr Asp Asp Gln Arg Asn Arg Leu Gln Glu 
     130                135                140
Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Pro Glu Gln Met 
 145                150                155                160
Ser Gln Val Leu Asp Ala Met Phe Glu Lys Leu Val Lys Glu Gly Glu 
                 165                170                175
His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr Val Ile Asp 
             180                185                190
Arg Gly Thr Phe Asp Ile Tyr Val Lys Cys Asp Gly Val Gly Arg Cys 
         195                200                205
Val Gly Asn Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu Ala Leu Met 
     210                215                220
Tyr Asn Thr Pro Arg Ala Ala Thr Ile Thr Ala Thr Ser Pro Gly Ala 
 225                230                235                240
Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile Val Lys Asn 
                 245                250                255
Asn Ala Lys Lys Arg Lys Met Tyr Glu Ser Phe Ile Glu Ser Leu Pro 
             260                265                270
Phe Leu Lys Ser Leu Glu Val Ser Glu Arg Leu Lys Val Val Asp Val 
         275                280                285
Ile Gly Thr Lys Val Tyr Asn Asp Gly Glu Gln Ile Ile Ala Gln Gly 
     290                295                300
Asp Ser Ala Asp Ser Phe Phe Ile Val Glu Ser Gly Glu Val Arg Ile 
 305                310                315                320
Thr Met Lys Arg Lys Gly Lys Ser Asp Ile Glu Glu Asn Gly Ala Val 
                 325                330                335
Glu Ile Ala Arg Cys Leu Arg Gly Gln Tyr Phe Gly Glu Leu Ala Leu 
             340                345                350
Val Thr Asn Lys Pro Arg Ala Ala Ser Ala His Ala Ile Gly Thr Val 
         355                360                365
Lys Cys Leu Ala Met Asp Val Gln Ala Phe Glu Arg Leu Leu Gly Pro 
     370                375                380
Cys Met Glu Ile Met Lys Arg Asn Ile Ala Thr Tyr Glu Glu Gln Leu 
 385                390                395                400
Val Ala Leu Phe Gly Thr Asn Met Asp Ile Val Glu Pro Thr Ala 
                 405                410                415



<210> 3286
<211> 3259
<212> DNA
<213> Homo sapiens
<308> M31158
<400> 3286

gacgcgcgc  gggagccgg  ggccgggcc  gccggcgcc  gggcccagt  cgccgcgct  60
gcagccggt  gcgcgccag  cgtaggcgt  gctcggcag  cgcggggcc  taggcgtgc  120
ggggagggg  cgagggcgg  caggcgcct  ccgccccgg  ggcaggatg  gcatcgaga  180
cccggcggg  ctgacggag  tgctgcagg  cttcacggt  gaggtgctg  ggcaccagc  240
cgcggacct  ctggagttc  cgctgcagc  cttcacccg  ctgcagcag  agaacgagc  300
caaaggcac  gcgcgcttc  gccatgagg  caggacctg  ggggacctg  gcgccgctg  360
cgggggcgg  acccccagc  agggggtca  cttcgccga  gagcccatg  agtccgact  420
cgaggacgg  gaggaggag  aggcggcgc  cgcggacgc  ggggcgttc  atgctccag  480
aataaaccg  ttcacaagg  gtgcctcag  atgtgcaga  gcttataat  ctgatgaag  540
agaagatga  gcagagtcc  ggattatac  tccaaaaac  gatgatcaa  gaaataggt  600
gcaagaggc  tgcaaagac  tcctgctgt  taagaatct  gatccggag  agatgtctc  660
agtattaga  gccatgttt  aaaaattgg  caaagatgg  gagcatgta  ttgatcaag  720
tgacgatgg  gacaacttt  atgtaattg  tagaggcac  tttgatatt  atgtgaaat  780
tgatggtgt  ggaagatgt  ttggtaact  tgataatcg  gggagtttc  gcgaactgg  840
cttaatgta  aatacaccc  gagcagcta  aatcactgc  acctctcct  gtgctctgt  900
gggtttgga  agggtaacc  tcaggagaa  aattgtgaa  aacaatgcc  aaaagagaa  960
aatgtatga  agctttatt  agtcactgc  attccttaa  tctttggag  tttctgaac  1020
cctgaaagt  gtagatgtg  taggcacca  agtatacaa  gatggagaa  aaatcattg  1080
tcagggaga  tcggctgat  cttttttca  tgtagaatc  ggagaagtg  aaattacta  1140
gaaaagaaa  ggtaaatca  aagtggaag  gaatggtgc  gtagaaatg  ctcgatgct  1200
gcggggaca  tactttgga  agcttgccc  ggtaactaa  aaacctcga  cagcttctg  1260
ccacgccat  gggactgtc  aatgtttag  aatggatgt  caagcattt  aaaggcttc  1320
gggaccttg  atggaaatt  tgaaaagga  catcgctac  tatgaagaa  agttagttg  1380
cctgtttgg  acgaacatg  atattgttg  acccactgc  tgaagcaaa  gtatggagc  1440
agacctgta  tgacaaaat  acacagtag  ggttagtcc  ctgagaatg  gtttgtgta  1500
atgccaagc  ttttctgtg  tttcaggtt  tttcctttt  ttacattta  aacgtatca  1560
taaacagta  tgatttaat  gtcaatagg  tttaacatc  ctttctaaa  agtagttca  1620
aaaaaaatc  acatactga  aaaatgact  tgtactcca  aaaattatg  ctgaaaggt  1680
tattaaaat  attgtaata  atagaaagt  tctgtgttt  agaagataa  taaaggatg  1740
tatcatagg  tatatgtgt  ttacttatt  agactgata  tcatattag  gactatccc  1800
atgtaagag  gcacttggc  attaaacat  ctacacagc  tggcatcac  tttttttat  1860
actcattaa  cacagtaaa  ttttaatca  ttttgtttt  aagttttct  gcttgataa  1920
ttatgtgct  ccttggcct  ttggtgaaa  ggtataaaa  atcatatgc  gttttaaaa  1980
tttttatat  tttgcaata  agtacattt  gactttgtt  gcataatgt  agtaacata  2040
atattccag  ggttttatg  acaggcaat  tagtcatta  gataataag  aaaacagtg  2100
tttagatga  agatcatta  tgcattttt  cctcatcaa  catatatct  ctttttttt  2160
ttttgcaat  ctctgtatt  tatgtcttt  aaaatttga  cttgacatt  aatgtcaca  2220
agttttgtt  ttttaaaaa  tgatttaaa  ttaagatcc  acatttttt  tattcttta  2280
gattttaca  ctaaaaaat  tctcctatc  caaaaataa  gtgggatcc  tatcagcat  2340
cccacagtt  atttctttg  tcttcacta  gcctgcata  tacagtcct  tgtagacat  2400
tgttccctt  ggtttccgt  ctttcttag  atggttgcc  acccacaat  tcattgatc  2460
gcagccaat  tgggtttgt  tggtttttt  aattcttaa  aacatcctc  agaggaata  2520
aaacaaatt  ttatgagca  aaccctata  aaagacaaa  tgaatttct  accttacca  2580
atataccat  aggccttgc  attgcttta  tgtagactc  tagttgaaa  tagtgcaga  2640
agaactcag  tgtactaga  tttcattgt  cattgatat  ctcagtatg  tgccacata  2700
gatgaattt  attatattc  accaaagca  tatactctt  catgatttc  aggccccat  2760
acccagtgt  tagagacat  aattctaac  agttgtttg  ttttaaatg  gtgatttca  2820
tttgggaaa  aggtttcaa  tgaatatat  tacatgggt  aaattactc  gtgctagtg  2880
agtcttact  gagaatgtt  atggtccca  ttgtatatg  aaatgtggt  agaatgtta  2940
ttggataat  tatatataa  aagttaaag  atgtaaagt  taacttcag  cacattttt  3000
gaacactgt  taacatttt  gcaaaacct  cttgtagga  aagagagct  tctacatga  3060
gatgacttg  tttatattt  agattttat  ttaaaagcc  tgtctgtta  acaagaaaa  3120
acacaaaag  actccagat  cctggttca  cattctgta  tcttactca  tttttcaag  3180
tatctattt  gttgcataa  ctaattgtt  actattcat  gaacagcaa  cgcctgttt  3240
ataaagaac  ttgaccaag  3259



<210> 3287
<211> 417
<212> PRT
<213> Homo sapiens
<308> P31323
<400> 3287

Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe Thr 
  1               5                  10                  15
Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala Leu 
             20                  25                  30
Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg Lys Gly Thr Ala 
         35                  40                  45
Arg Phe Gly His Glu Gly Arg Thr Trp Gly Asp Leu Gly Ala Ala Ala 
     50                  55                  60
Gly Gly Gly Thr Pro Ser Lys Gly Val Asn Phe Ala Glu Glu Pro Met 
 65                  70                  75                  80
Gln Ser Asp Ser Glu Asp Gly Glu Glu Glu Glu Ala Ala Pro Ala Asp 
                 85                  90                  95
Ala Gly Ala Phe Asn Ala Pro Val Ile Asn Arg Phe Thr Arg Arg Ala 
             100                105                110
Ser Val Cys Ala Glu Ala Tyr Asn Pro Asp Glu Glu Glu Asp Asp Ala 
         115                120                125
Glu Ser Arg Ile Ile His Pro Lys Thr Asp Asp Gln Arg Asn Arg Leu 
     130                135                140
Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Pro Glu 
 145                150                155                160
Gln Met Ser Gln Val Leu Asp Ala Met Phe Glu Lys Leu Val Lys Asp 
                 165                170                175
Gly Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr Val 
             180                185                190
Ile Asp Arg Gly Thr Phe Asp Ile Tyr Val Lys Cys Asp Gly Val Gly 
         195                200                205
Arg Cys Val Gly Asn Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu Ala 
     210                215                220
Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Thr Ala Thr Ser Pro 
 225                230                235                240
Gly Ala Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile Val 
                 245                250                255
Lys Asn Asn Ala Lys Lys Arg Lys Met Tyr Glu Ser Phe Ile Glu Ser 
             260                265                270
Leu Pro Phe Leu Lys Ser Leu Glu Phe Ser Glu Arg Leu Lys Val Val 
         275                280                285
Asp Val Ile Gly Thr Lys Val Tyr Asn Asp Gly Glu Gln Ile Ile Ala 
     290                295                300
Gln Gly Asp Ser Ala Asp Ser Phe Phe Ile Val Glu Ser Gly Glu Val 
 305                310                315                320
Lys Ile Thr Met Lys Arg Lys Gly Lys Ser Glu Val Glu Glu Asn Gly 
                 325                330                335
Ala Val Glu Met Pro Arg Cys Ser Arg Gly Gln Tyr Phe Gly Glu Leu 
             340                345                350
Ala Leu Val Thr Asn Lys Pro Arg Ala Ala Ser Ala His Ala Ile Gly 
         355                360                365
Thr Val Lys Cys Leu Ala Met Asp Val Gln Ala Phe Glu Arg Leu Leu 
     370                375                380
Gly Pro Cys Met Glu Ile Met Lys Arg Asn Ile Ala Thr Tyr Glu Glu 
 385                390                395                400
Gln Leu Val Ala Leu Phe Gly Thr Asn Met Asp Ile Val Glu Pro Thr 
                 405                410                415
Ala 
             420



<210> 3288
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3288

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3289
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3289

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3290
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3290

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3291
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3291

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3292
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3292

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3293
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3293

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3294
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3294

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3295
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3295

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3296
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3296

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3297
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3297

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3298
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3298

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3299
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3299

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3300
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3300

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3301
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3301

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3302
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3302

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3303
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3303

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3304
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3304

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3305
<211> 8048
<212> DNA
<213> Rattus norvegicus
<308> M13100
<400> 3305

gaattcggc  caggataaa  agatatata  gtaaatgac  ggatagata  atggatttg  60
tctctaact  aacttaggc  ccatagaaa  caatccttg  attatttta  taattttaa  120
tcctagttt  ctgagaaac  cgttgacga  gcagggctt  agcctctct  aagcagcac  180
gcccctctg  ggccacaca  gaagtcttc  ctcagcagt  tcctgactt  aggcctagg  240
ctgaggaaa  gcattgaat  tttctctgg  ggacaatag  tctgagaag  aaagagagt  300
tgtctatgt  gaggtcagt  aaggatggt  ttctttcct  ccctcccag  cttttctcc  360
tgcaacatc  tgagtcccc  tctttctat  ctgcctaaa  ccacttcct  ctgggaaat  420
agaaaatcc  ctcatacaa  atggaaaca  cccgaggat  ccggcccgc  gcagctctc  480
gcccccaga  cctgtgaga  agagaccca  ccgcctggt  aggtgggca  tcctgaggc  540
gcagaggga  gagaccacc  acactgctc  cccctgccc  catccctgg  ccaagagga  600
actgtataa  gcctctggg  cctgtgggg  agggcccag  agcggcagg  cccctgtgc  660
tgagagacc  ccaccagaa  cagaaggaa  cagaccgga  aaacagttc  ctgcaccaa  720
tcccgtgga  ggagagctg  accttcaga  agaaagaca  gcctgggaa  ccagaagag  780
ctgctctct  cacacacat  tcggacgcc  gaggaaaaa  ccaaagacc  tctggaacc  840
tggtgcact  aagctcccg  aaatggtgc  caggtcttc  tggttgctg  cgctgcaga  900
agcccgtgg  agcacccca  gagcgaact  gagcctcag  accacaggt  agaccaact  960
ttctgctgc  agaaagctg  ctggtgaac  caagacaca  gcccacagg  acagctgaa  1020
acctgtaga  aggaaaaac  acacgccgg  aagcagaac  ctctgtccc  ataactgac  1080
gaaagagag  aaaacaggt  tacagcact  ctgacacac  ggcttatag  acagtctag  1140
cactgtcag  aatagcaga  caaagtaac  ctagagata  tctgatggc  aaaggcaag  1200
gcaggaacc  aagcaacag  aaccaagac  acatggcac  atcggagcc  aattctccc  1260
tcaaaacaa  catggaata  ccaaacaca  cagaaaagc  agatctagt  ccaaaatca  1320
ttttgatca  gatgctgga  gacttcaag  aagacgtga  gaactcctt  gagaacaag  1380
agaagccta  agagaggaa  cgcaaaaat  cctgaaaga  tcgcaaaaa  ccctgaaag  1440
attccaaga  aacataaat  aacaagtag  agcccatag  gaggagaca  aaaaatccc  1500
gaaagaatt  caggaaaac  taaataaac  agtagaagc  catagagag  agacacaaa  1560
atccctgaa  gaattccag  aaaacataa  taaacaagt  gaagcccat  gagaggaga  1620
acaaaaatc  ctgaaagga  ttccaggaa  acacaatca  acagttgaa  gaattaaaa  1680
tggaaatag  agcaatcaa  aaagaacac  tggaaacaa  cctggatat  gaaaaccaa  1740
agaagagac  aggagctgt  gataaaagc  tcaccaaca  aatacaaga  atggaagag  1800
gaatctcag  agcagaaga  tccatagaa  tcattgact  aactgtcaa  gataatgta  1860
agcggaaaa  gctactggt  caaaacata  aggaaatcc  ggactcaat  agaagatca  1920
acctaagga  aataggtat  gaagagagt  aagactccc  gctcaaagg  ccagtaaat  1980
tcttcaaca  aaccataga  gaaancttc  ctaacctaa  aaaagagat  cccatagac  2040
cacaagaag  ctacagaac  ccaaataga  tggaccaga  aagaaacac  tcccgtcac  2100
taattgtca  aacaccaaa  gcacaaaat  aagaaagaa  attaaaaac  gtaagggaa  2160
aaggtcaag  aacatataa  gggagacct  tcagaatca  accagactt  tcgccagaa  2220
ctatgaagg  cagaagatc  tggactgat  ttatacaga  cctaagaga  cacaaatgc  2280
agcccaggt  actgtatcc  gcaaaactc  caattaaca  tgatggaga  accaagaca  2340
tccatgaca  aaccaaatt  acacaatat  tttccacaa  tccagcact  caaaggata  2400
taaatggta  agcccaaca  aaggaggca  gctataccc  agaagaagc  agaaactaa  2460
cgtcttggc  acaaaacaa  gagaatgaa  gcacacaaa  ataacctca  atccaaata  2520
gaatataac  ggaagcaat  atcactatt  cttaatatc  ctcaacatc  atggcctca  2580
ctccccaat  aaaagtcat  gattaacaa  ctggataca  aacgaggac  ctgcattct  2640
ctgcctaca  gaaacacac  tcagagaca  agacagaca  tacctcaga  tgaaaggct  2700
gaaaacaaa  ttccaagca  atggtcaga  gaagcaagc  ggagtagcc  ttctaatat  2760
aaataaaat  aatttccaa  taaaagtca  caaaaaaga  aaggaagga  acttcatat  2820
catcaaagg  aaaatccac  aagatgaac  ctcaatcct  aatatctat  ccccaaata  2880
aagggcacc  acatacgta  aagaaacct  actaaagct  aaagcacac  ttgcacctc  2940
cacaataat  gtgggagat  tcaacacac  actctcatc  atggacaga  catggaaac  3000
gaaattaaa  agtgatgtc  acagcataa  agaagtcat  agccaaatg  acttaacgg  3060
tatttttag  acattctat  ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  3120
cactttctc  aaaattgac  atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  3180
gatagaaat  atcccatgc  tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  3240
caataaggg  agaatgccc  catatacct  gaaattgaa  aatgctcta  tcaatgata  3300
cctggtcaa  gaagaaata  agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  3360
aggtacaac  tacccaaac  tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  3420
agcgctgag  gcctgcaaa  agaaacagg  aagagcata  gtcagcagc  tgacagcac  3480
cctaaaagc  ctagaacaa  aangaagca  atacactga  gaggagtag  aggcaggaa  3540
taatcaaac  cagagctga  atcaaccaa  tagaaacaa  aaggaccat  gaaagaatc  3600
acagaacca  aagctggtt  tttgagaaa  tcaacaaga  agataaacc  ttagccaga  3660
taacgagag  acacagaga  tgtgtccaa  ttaacaaaa  cagaaatga  aagggagac  3720
taactacag  ttcagagga  attcaaaaa  tcatcagat  ttactataa  aacctatat  3780
caataaaac  tgaaaatct  caggaaatg  acaatttcc  agacagata  cacgtatcg  3840
agttaaatc  ggaacagat  aaccagtta  acaacccca  aactcctaa  gaaatagaa  3900
cagtcatta  aggtctccc  accaaaaag  gtccaggtc  agacgggtt  agtgcagaa  3960
tctatcaaa  cttcataga  gacctcata  caatattat  caaactatt  cacaaaatt  4020
aaacagatg  agcactacc  aattccttc  acgaagcca  aattactct  atacctaaa  4080
cacacaaag  cacaacaaa  aaagagaac  tcagaccaa  ttcccttat  aatatcgat  4140
caaaaatac  caataaaat  ctggcaaac  aattcaaga  cacatcaaa  caatcatcc  4200
ccatgatca  gtaggcttc  tcccaggca  gcagggatg  tttaatata  ggaaaacca  4260
caacgtgat  cattatata  acaaactga  agaacagaa  cacatgatc  tttcattag  4320
tgctgagaa  gcatttgac  aaattcaac  cccttcatg  taagagtcc  ggaaagaat  4380
ggaattcaa  gcccatacc  aaacatagt  aaagccata  acagcaaac  agttgctaa  4440
attaaacta  atggagaga  acttgaagc  atcccacta  aatcaggga  tagacaagg  4500
tgcccactc  ctccctact  attcaatat  gttcttgaa  ttctagcca  accaatcag  4560
caacaaaag  agatcaagg  gatacagat  ggaaaagaa  aagtcaaaa  atcactatt  4620
gcagatgac  tgatagtat  tttaagtga  cccaaaagt  ccaccagag  acgactaaa  4680
ctgataaac  acttcagca  agtggctgg  tataaaatt  actcaaata  atcagttgc  4740
ttcctctat  caaaagaga  acaagccga  aaagaaatt  gggaaacga  acccttcat  4800
atagaccca  ataatataa  gtacctcgg  gtgacttta  ccaagcaag  aaaagatct  4860
tacaataag  acttcaaga  actgaggaa  gaaattgaa  aagacctca  aagatggaa  4920
gatctccca  gctcatgga  tggcaggat  aatatagta  aaatggcca  tttacccaa  4980
gcaatctac  gattcaatg  aatccccat  aaaatacca  tccaattct  caaagagtt  5040
gacagaaca  tttgcaaat  catctggaa  aacaaaaaa  ccaggatag  taaagctat  5100
ctcaacaat  aaaggactt  agggggaat  actatccct  aactcaagc  gtattacag  5160
gcaatagtg  taaaaactg  atggtgatt  gtacagaga  agacagata  accaatgga  5220
tagaactga  gacccagaa  tgaacccac  cacctatgg  cacttgatt  ttgacaaag  5280
agccaaaac  atccaatgg  aaaaagata  cattttcag  aaatggtgc  ggttcaact  5340
gagggcaac  tgtagaaga  tgcagatcg  tccatcctt  tcaccctgt  caaagctta  5400
gtccaagtg  atcaaggac  tccacatca  accagacac  ctcaaacta  tagaagaaa  5460
actagggaa  catctggaa  acatgagca  tggaaaaaa  ttcctgaac  aaacaccaa  5520
ggcttatgc  ctaagatca  gaatcgaca  atgggatct  ataaaactg  aaagcttct  5580
taaggcaaa  gacactgtg  ttaggacaa  acggcaacc  acagattgg  aaaagatct  5640
taccaatcc  acaacagat  gaggcctta  atccaaaat  tacaaagaa  tcaagaagt  5700
agaccgcag  aaacaaata  ccctattaa  aatggggtt  agagctaaa  aaaaattca  5760
agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  tgttcaaca  ctttagtca  5820
aagggaaat  caaatcaaa  caaccctga  atttcacct  acagtagtg  gaatggcta  5880
gatcaaaaa  tcaggtgac  gcagatgct  gcgaggatg  ggagaaaga  gaacactcc  5940
ccattgttg  tgggattgc  gactggtaa  accattctg  aaatcagtc  ggaggttcc  6000
cagaaaatt  gacattgaa  tgcctgagg  tccagctat  cctctcttg  gcatatacc  6060
aaaagatgc  tcaacatat  aaagagaca  gtgctccac  atgttcatt  ccgccatat  6120
tataatagc  agaaactgg  aagaaccca  atgcccttc  acagaggaa  ggatacaga  6180
aatgtggta  atctacaca  tggaatatt  ctcagctat  aaaaacaac  agtttatga  6240
attcgtagg  aaatggttg  aactggaaa  tatcatcct  agtgagcta  cccactcac  6300
gaaagacat  catggtatg  actcattga  aagtggcta  tagcccaaa  gcttgaatt  6360
ccctagatc  ctagaacaa  cgaaactca  gacggatga  caaaatgtg  atgcttcac  6420
ccttcttta  atgaggaaa  agaataccc  tggctggga  gggagaggc  aagattaaa  6480
cagagactg  aggaacacc  attcagagc  tgccccaca  gtggcccat  catatacag  6540
cacccaatt  gacaagatg  atgaagcaa  gaagtgcag  ctgacagga  ccggatgta  6600
atcgctcct  agagacaca  ccagaatac  gcaaataca  aggcgaatg  cagcagcaa  6660
ccactgaac  gagaatagg  cccccgttg  aggaatcag  gaaagaact  gaagagctt  6720
aaggggctc  agaccccaa  agtacaaca  tgtcaagca  ccagagctt  cagggacta  6780
gccactacc  aaatactat  catggactg  ccctggact  tgaccccat  ggtagcaat  6840
aatatccta  taagagcac  agtggaagg  gaagccctg  gtcctgcta  gactggacc  6900
ccagtgaac  agactatgg  gggagggcg  caatggggg  agggttggg  gggggacac  6960
cataaggaa  gggaggggg  agggggatg  ttacccgga  accgaaagg  aataacact  7020
aaattatat  agaaatact  aagttaatt  aaaataata  taataataa  aaaaagaat  7080
actcataaa  taaagacaa  atgatggat  aaattaaaa  aacaaaaaa  acaaaaaaa  7140
accaaaatg  aaacatgaa  atgctcact  cttacaata  tgctttatg  aataagcaa  7200
tgactgcat  tgacacgag  tataattta  taacccctt  gttagacta  ttgtacaca  7260
ggtgattat  aatccacaa  tattctttt  cactaaaat  cttatattt  attctttga  7320
attataata  aatcacaca  attccctct  ccctgtcat  tcttcaaaa  cttccatat  7380
gtcctccat  ctgtctttt  aacgttatg  cttcttttt  atattcttg  tttatatta  7440
atatatata  tatatatta  aatatatat  atactatat  tattcctca  gactgacca  7500
tccatattg  ataaccaat  ggtgtgctc  tctcaggga  agaccattt  cccaccatc  7560
gcattctcg  tttccagta  ttcattgtc  agaatggag  ctgtgtgtg  tttccccgt  7620
cactttagc  gctgtgttt  agctcctct  gaggcagtt  tgttggtga  acctcatct  7680
tgcggcttc  aacattcct  agagacaca  tgagttaca  agtgtcacc  gatcctcta  7740
ctcccacca  ctttcctgc  gtcttctcc  gggtttcct  aacctcagc  ggagcaggg  7800
ttgtactgt  gacacgccc  ccttcacta  gatccacag  tcctcactt  gatttgctg  7860
ggttttctg  aatggcttc  atgtcctag  aaagtcatg  agaccccat  accacgctg  7920
actaaacca  acaatccct  gctgcattc  aagttcttg  ccttatccc  tacatgtgc  7980
tttagagag  ctgcttatt  tgctcatta  agaacgagt  aatcattct  tttgagttg  8040
aaaagctt  8048



<210> 3306
<211> 2472
<212> DNA
<213> Rattus norvegicus
<308> M13962
<400> 3306

ccccgcatg  ccccaagac  gagtgtgtg  tggttcgta  tgggccagc  gctgtgcag  60
tgcgccgtg  cgctgcagg  cgggatgct  ttcccgaag  agacccctt  gcgggaact  120
aaggtgctg  acggcctgt  gagcttccg  gccgattac  cgaacaatc  gttgcaggg  180
ttcgagaag  agtggtacc  gcagccgct  cgggagtcg  gcccaacct  ggacatgcc  240
gtcccttcc  gcttcaatg  catcaccca  gaagcagag  ttcggaact  cattggctg  300
gtgtggtat  aacgggaag  agtgcttcc  cagcgatgg  cccaggaca  cgacaggag  360
gtggtgttg  gaatcaaca  cgcccatta  tatgcagtt  tgtgggtga  tgggattca  420
gtggtggaa  atgagggag  tcacctccc  tttgaggct  acatcacca  gctggtcca  480
agtgggccc  tgaccacct  ccgggtcac  atcgccatc  acaacacac  gacccctta  540
acccttcca  cggggacca  tgtctacaa  actgatcct  ccatgtatc  caagggtta  600
ttcgtccag  acataagct  cgacttctt  aactatgcg  ggctgcacc  gtctgtggt  660
ctgtacacc  cccctacca  ctatatcga  gatatcact  tgaccactg  cgtggaccg  720
gacgttggg  tggtgaact  ctggatttc  gtccagggc  gtgaccatt  ccagctaga  780
gtgcgtctt  tggatgagg  tggcaaaat  gtggcccgt  gaacaggga  tgagggtca  840
cttaaggtg  cgcgtgccc  cctctggtg  ccttacctg  tgcatgagc  tccagccta  900
ctgtactcc  tggaggtga  gatgacaac  cctgagtct  tgtctgact  ctataccct  960
cctgtcggg  ttcgaacag  ggctgtcac  aagagcaag  tcctcataa  tgggaagcc  1020
ttctacttc  aaggcgtca  caagcatga  gattcagat  tccgaggga  aggcttcga  1080
tggcctctg  tgataaagg  tttcaacct  ctccgttgg  tcggggcaa  ttcctttcg  1140
accagccac  atccctact  ggaggaggt  cttcagctc  gtgaccgat  tggaattgt  1200
gtcatcgat  agtgtcccg  tgtgggcat  gtgctgccc  agagttttg  caacgtgtc  1260
cttcggcac  acctagagg  gatggacga  ctggtgcgc  gggacaaaa  tcaccctgc  1320
gtcgtgatg  ggtctgtgg  caatgagcc  gtctcttct  tgaaacctg  cggatatta  1380
ttcaagacg  tgatcgccc  caccaaagc  ctggacccc  cccgtcctg  gacctttgt  1440
agcaatacc  gatatgacg  agacatggg  gccccgtac  tggacgtga  ttgtgtgaa  1500
agttactta  cctggtatc  tgactacgg  catctggag  tgattcagc  gcagctgac  1560
agccagttt  agaactggt  taagatgta  cagaagcca  ttatccaga  cgagtatgg  1620
gcagacgcc  tctcggggc  tcatgagga  ccacctcgc  tgttcagtg  ggagtacca  1680
acagctctc  tggagaatt  tcatttgat  ctggatgag  aacgaaaag  atatgtcat  1740
ggagagctc  tctggaatt  tgctgactt  atgacgaac  agtcaccac  gagagtaac  1800
ggaaacaag  aggggatct  cactcgaca  agaaacccc  agatggcag  cttcatttt  1860
cgagagaga  actggagga  tgccaacga  accagaggt  acggttcag  gccgaggac  1920
cagtgtatg  gaagcagac  gttcacatt  taaagctac  actacctca  cgcagacag  1980
gcctgatga  gtgaaaggt  ttctctcag  agaagagtt  ttcctctgg  gtttgtgaa  2040
caacacaag  aggacttta  aagtgacat  gaagttttc  ttgtgtggg  ataatgact  2100
gcagtgcct  aggctcagt  atgtgtcct  ctgagaagt  tcccaggtc  tttctgtca  2160
gtttttttt  gccttggct  tgtgtactc  tgaaaacct  ctgtgtgaa  actcacact  2220
agagctcct  gttaccggc  aagggacgg  tcacaattt  agaatactg  ctgttctac  2280
aggggttcc  gattcgatt  ctagcaccc  cgtggtcgt  aactatgag  tgttgcccc  2340
tttctcagg  gatgtacga  catacatgt  gggggaggg  aatagtcat  cgtgtaaaa  2400
gaaaataaa  ctaaataaa  ctgttttct  tcattataa  aaaaaaaaa  aaaaaccaa  2460
taatagaaa  gt  2472



<210> 3307
<211> 648
<212> PRT
<213> Rattus norvegicus
<308> P06760
<400> 3307

Met Ser Pro Arg Arg Ser Val Cys Trp Phe Val Leu Gly Gln Leu Leu 
  1               5                  10                  15
Cys Ser Cys Ala Val Ala Leu Gln Gly Gly Met Leu Phe Pro Lys Glu 
             20                  25                  30
Thr Pro Ser Arg Glu Leu Lys Val Leu Asp Gly Leu Trp Ser Phe Arg 
         35                  40                  45
Ala Asp Tyr Ser Asn Asn Arg Leu Gln Gly Phe Glu Lys Gln Trp Tyr 
     50                  55                  60
Arg Gln Pro Leu Arg Glu Ser Gly Pro Thr Leu Asp Met Pro Val Pro 
 65                  70                  75                  80
Ser Ser Phe Asn Asp Ile Thr Gln Glu Ala Glu Leu Arg Asn Phe Ile 
                 85                  90                  95
Gly Trp Val Trp Tyr Glu Arg Glu Ala Val Leu Pro Gln Arg Trp Thr 
             100                105                110
Gln Asp Thr Asp Arg Arg Val Val Leu Arg Ile Asn Ser Ala His Tyr 
         115                120                125
Tyr Ala Val Val Trp Val Asn Gly Ile His Val Val Glu His Glu Gly 
     130                135                140
Gly His Leu Pro Phe Glu Ala Asp Ile Thr Lys Leu Val Gln Ser Gly 
 145                150                155                160
Pro Leu Thr Thr Phe Arg Val Thr Ile Ala Ile Asn Asn Thr Leu Thr 
                 165                170                175
Pro Tyr Thr Leu Pro Pro Gly Thr Ile Val Tyr Lys Thr Asp Pro Ser 
             180                185                190
Met Tyr Pro Lys Gly Tyr Phe Val Gln Asp Ile Ser Phe Asp Phe Phe 
         195                200                205
Asn Tyr Ala Gly Leu His Arg Ser Val Val Leu Tyr Thr Thr Pro Thr 
     210                215                220
Thr Tyr Ile Asp Asp Ile Thr Val Thr Thr Asp Val Asp Arg Asp Val 
 225                230                235                240
Gly Leu Val Asn Tyr Trp Ile Ser Val Gln Gly Ser Asp His Phe Gln 
                 245                250                255
Leu Glu Val Arg Leu Leu Asp Glu Asp Gly Lys Ile Val Ala Arg Gly 
             260                265                270
Thr Gly Asn Glu Gly Gln Leu Lys Val Pro Arg Ala His Leu Trp Trp 
         275                280                285
Pro Tyr Leu Met His Glu His Pro Ala Tyr Leu Tyr Ser Leu Glu Val 
     290                295                300
Thr Met Thr Thr Pro Glu Ser Val Ser Asp Phe Tyr Thr Leu Pro Val 
 305                310                315                320
Gly Ile Arg Thr Val Ala Val Thr Lys Ser Lys Phe Leu Ile Asn Gly 
                 325                330                335
Lys Pro Phe Tyr Phe Gln Gly Val Asn Lys His Glu Asp Ser Asp Ile 
             340                345                350
Arg Gly Arg Gly Phe Asp Trp Pro Leu Leu Ile Lys Asp Phe Asn Leu 
         355                360                365
Leu Arg Trp Leu Gly Ala Asn Ser Phe Arg Thr Ser His Tyr Pro Tyr 
     370                375                380
Ser Glu Glu Val Leu Gln Leu Cys Asp Arg Tyr Gly Ile Val Val Ile 
 385                390                395                400
Asp Glu Cys Pro Gly Val Gly Ile Val Leu Pro Gln Ser Phe Gly Asn 
                 405                410                415
Val Ser Leu Arg His His Leu Glu Val Met Asp Glu Leu Val Arg Arg 
             420                425                430
Asp Lys Asn His Pro Ala Val Val Met Trp Ser Val Ala Asn Glu Pro 
         435                440                445
Val Ser Ser Leu Lys Pro Ala Gly Tyr Tyr Phe Lys Thr Leu Ile Ala 
     450                455                460
His Thr Lys Ala Leu Asp Pro Thr Arg Pro Val Thr Phe Val Ser Asn 
 465                470                475                480
Thr Arg Tyr Asp Ala Asp Met Gly Ala Pro Tyr Val Asp Val Ile Cys 
                 485                490                495
Val Asn Ser Tyr Leu Ser Trp Tyr His Asp Tyr Gly His Leu Glu Val 
             500                505                510
Ile Gln Leu Gln Leu Thr Ser Gln Phe Glu Asn Trp Tyr Lys Met Tyr 
         515                520                525
Gln Lys Pro Ile Ile Gln Ser Glu Tyr Gly Ala Asp Ala Val Ser Gly 
     530                535                540
Leu His Glu Asp Pro Pro Arg Met Phe Ser Glu Glu Tyr Gln Thr Ala 
 545                550                555                560
Leu Leu Glu Asn Tyr His Leu Ile Leu Asp Glu Lys Arg Lys Glu Tyr 
                 565                570                575
Val Ile Gly Glu Leu Ile Trp Asn Phe Ala Asp Phe Met Thr Asn Gln 
             580                585                590
Ser Pro Leu Arg Val Thr Gly Asn Lys Lys Gly Ile Phe Thr Arg Gln 
         595                600                605
Arg Asn Pro Lys Met Ala Ala Phe Ile Leu Arg Glu Arg Tyr Trp Arg 
     610                615                620
Ile Ala Asn Glu Thr Arg Gly Tyr Gly Ser Val Pro Arg Thr Gln Cys 
 625                630                635                640
Met Gly Ser Arg Pro Phe Thr Phe 
                 645



<210> 3308
<211> 873
<212> DNA
<213> Homo sapiens
<308> BM019597
<400> 3308

gcttttgga  gcagaaaac  aagtcgtgg  gaatgggac  gggacccag  ccaacttaa  60
gtgccaggt  tcagcctct  gtggccgta  ctgatgcac  aacgccctg  ctatctgta  120
tcattggag  tgcagctga  tgcacagac  tcactgggg  ctgtgtctg  cttctacac  180
ctccctgtg  ggatccgca  tgtggctgt  accaagagc  agttcctca  caatgggaa  240
cctttctat  tccacggtg  caacaagca  gaggatgcg  acatccgag  gaagggctt  300
gactggccg  tgctggtga  cggacttca  cctgcttcg  tggcttggt  ccaacgctt  360
ccgtaccag  cactacccc  atgcagagg  agtgatgca  atgtgtgac  gctatggga  420
tgtggtcat  gatgagtgt  ccggcgtgg  cctggcgct  ccgcagttc  tcaacaacg  480
ttctctgca  caccacatg  aggtgatgg  agaagtggt  cgtagggac  agaaccacc  540
gcggtcgtg  tgtggtctg  ggccacgag  ctgcgtccc  cctagaatc  gctggctac  600
acttgaagc  ccgtatgtg  atgtgatct  tttgaacag  tactactct  ggtatcacg  660
ctacgggca  ctggagttg  ttcagctgc  gctggccac  cagtttgag  actggtata  720
gaagtatca  aagcccatt  tccagagcg  gtatggagc  gaccacgat  tgcagggtt  780
caccaggat  cacctcctg  tgtcacttg  aggagtacc  ggaaaagtc  gctaaagca  840
tacatctgg  tctggattc  cacgcgtaa  tac  873



<210> 3309
<211> 651
<212> PRT
<213> Homo sapiens
<308> P08236
<400> 3309

Met Ala Arg Gly Ser Ala Val Ala Trp Ala Ala Leu Gly Pro Leu Leu 
  1               5                  10                  15
Trp Gly Cys Ala Leu Gly Leu Gln Gly Gly Met Leu Tyr Pro Gln Glu 
             20                  25                  30
Ser Pro Ser Arg Glu Cys Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg 
         35                  40                  45
Ala Asp Phe Ser Asp Asn Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr 
     50                  55                  60
Arg Arg Pro Leu Trp Glu Ser Gly Pro Thr Val Asp Met Pro Val Pro 
 65                  70                  75                  80
Ser Ser Phe Asn Asp Ile Ser Gln Asp Trp Arg Leu Arg His Phe Val 
                 85                  90                  95
Gly Trp Val Trp Tyr Glu Arg Glu Val Ile Leu Pro Glu Arg Trp Thr 
             100                105                110
Gln Asp Leu Arg Thr Arg Val Val Leu Arg Ile Gly Ser Ala His Ser 
         115                120                125
Tyr Ala Ile Val Trp Val Asn Gly Val Asp Thr Leu Glu His Glu Gly 
     130                135                140
Gly Tyr Leu Pro Phe Glu Ala Asp Ile Ser Asn Leu Val Gln Val Gly 
 145                150                155                160
Pro Leu Pro Ser Arg Leu Arg Ile Thr Ile Ala Ile Asn Asn Thr Leu 
                 165                170                175
Thr Pro Thr Thr Leu Pro Pro Gly Thr Ile Gln Tyr Leu Thr Asp Thr 
             180                185                190
Ser Lys Tyr Pro Lys Gly Tyr Phe Val Gln Asn Thr Tyr Phe Asp Phe 
         195                200                205
Phe Asn Tyr Ala Gly Leu Gln Arg Ser Val Leu Leu Tyr Thr Thr Pro 
     210                215                220
Thr Thr Tyr Ile Asp Asp Ile Thr Val Thr Thr Ser Val Glu Gln Asp 
 225                230                235                240
Ser Gly Leu Val Asn Tyr Gln Ile Ser Val Lys Gly Ser Asn Leu Phe 
                 245                250                255
Lys Leu Glu Val Arg Leu Leu Asp Ala Glu Asn Lys Val Val Ala Asn 
             260                265                270
Gly Thr Gly Thr Gln Gly Gln Leu Lys Val Pro Gly Val Ser Leu Trp 
         275                280                285
Trp Pro Tyr Leu Met His Glu Arg Pro Ala Tyr Leu Tyr Ser Leu Glu 
     290                295                300
Val Gln Leu Thr Ala Gln Thr Ser Leu Gly Pro Val Ser Asp Phe Tyr 
 305                310                315                320
Thr Leu Pro Val Gly Ile Arg Thr Val Ala Val Thr Lys Ser Gln Phe 
                 325                330                335
Leu Ile Asn Gly Lys Pro Phe Tyr Phe His Gly Val Asn Lys His Glu 
             340                345                350
Asp Ala Asp Ile Arg Gly Lys Gly Phe Asp Trp Pro Leu Leu Val Lys 
         355                360                365
Asp Phe Asn Leu Leu Arg Trp Leu Gly Ala Asn Ala Phe Arg Thr Ser 
     370                375                380
His Tyr Pro Tyr Ala Glu Glu Val Met Gln Met Cys Asp Arg Tyr Gly 
 385                390                395                400
Ile Val Val Ile Asp Glu Cys Pro Gly Val Gly Leu Ala Leu Pro Gln 
                 405                410                415
Phe Phe Asn Asn Val Ser Leu His His His Met Gln Val Met Glu Glu 
             420                425                430
Val Val Arg Arg Asp Lys Asn His Pro Ala Val Val Met Trp Ser Val 
         435                440                445
Ala Asn Glu Pro Ala Ser His Leu Glu Ser Ala Gly Tyr Tyr Leu Lys 
     450                455                460
Met Val Ile Ala His Thr Lys Ser Leu Asp Pro Ser Arg Pro Val Thr 
 465                470                475                480
Phe Val Ser Asn Ser Asn Tyr Ala Ala Asp Lys Gly Ala Pro Tyr Val 
                 485                490                495
Asp Val Ile Cys Leu Asn Ser Tyr Tyr Ser Trp Tyr His Asp Tyr Gly 
             500                505                510
His Leu Glu Leu Ile Gln Leu Gln Leu Ala Thr Gln Phe Glu Asn Trp 
         515                520                525
Tyr Lys Lys Tyr Gln Lys Pro Ile Ile Gln Ser Glu Tyr Gly Ala Glu 
     530                535                540
Thr Ile Ala Gly Phe His Gln Asp Pro Pro Leu Met Phe Thr Glu Glu 
 545                550                555                560
Tyr Gln Lys Ser Leu Leu Glu Gln Tyr His Leu Gly Leu Asp Gln Lys 
                 565                570                575
Arg Arg Lys Tyr Val Val Gly Glu Leu Ile Trp Asn Phe Ala Asp Phe 
             580                585                590
Met Thr Glu Gln Ser Pro Thr Arg Val Leu Gly Asn Lys Lys Gly Ile 
         595                600                605
Phe Thr Arg Gln Arg Gln Pro Lys Ser Ala Ala Phe Leu Leu Arg Glu 
     610                615                620
Arg Tyr Trp Lys Ile Ala Asn Glu Thr Arg Tyr Pro His Ser Val Ala 
 625                630                635                640
Lys Ser Gln Cys Leu Glu Asn Ser Pro Phe Thr 
                 645                650



<210> 3310
<211> 6322
<212> DNA
<213> Rattus norvegicus
<308> M14053
<400> 3310

gacgctgcg  gggtggggg  cctncggcg  cacggagtc  ccccccggg  tcacattaa  60
atttgccaa  ggactccaa  gaatcctta  ctccccctg  tagagacga  gtccctggc  120
gtttgcttg  ccaagggag  gggagcgta  tggactttt  taaaagcct  aggggagga  180
ctacagtca  ggtttctgc  tcttcgccc  cagtggctg  tgcttctca  gcagattcc  240
agcagcaga  gattctcct  gatttctcg  aaggctcca  aagcaatgt  cagcagcga  300
agcagcagc  gcagcagca  cagcagcag  agcagcagc  gcagcagca  cagcagcca  360
gcttatcca  agccgtttc  ctgtccatg  ggctgtata  gggagagac  gaaacaaaa  420
tgatgggga  tgacttggg  tacccacag  agggccaac  tggcctttc  tctggggaa  480
cagactttc  gcttctgga  gaaagcatt  caaacctca  taggtcgac  agcgttcca  540
agaacccca  gagttcaac  tctgcaact  ggtgtgcta  cccgacaga  aaggagttt  600
ccaaaactc  ctcggatgc  tcttcagaa  agcaaaatc  aaaaagcca  accggcacc  660
acggaggca  tgtgaaatt  tatcccaca  accaaagca  ctttgacct  ttgaaggat  720
tggagtttt  cgctgggtc  ccaagtaaa  acacaaacg  gagtccctg  agatcagat  780
tgttgatag  tgaaaactt  ctttctcct  tggcgggag  agatgatcc  ttccttctc  840
aagggaaca  gaatgagga  tgtaagcct  ttattttac  ggacactaa  cctaaaatt  900
aggatactg  agatacaat  ttatcaagt  ccagcagtg  ggcactacc  caagtgaaa  960
cagaaaaag  tgatttcat  gaactttgc  cccccgggg  aattaagca  gagaaactg  1020
gcccagttt  ttgtcaggc  agcttttct  ggacaaata  aattggtaa  aaaatgtct  1080
ccatttctg  tcatggtgt  agtacctct  gaggacaga  gtaccacta  gacatgaat  1140
cagcatccc  ttctcagca  caggatcag  agcctgttt  taatgtcat  ccaccaatt  1200
ctgttggtt  tgaaaactg  aataggtgc  aaggctccg  agaggacag  ctgacttcc  1260
tgggggctc  gaacttccc  ggccggtca  tgttttcta  tgggtactc  agccctgga  1320
tgagaccag  tgtaagctc  cctccatcc  gctcgtcag  agccacggg  ccacctccc  1380
agctctgcc  ggtgtgctc  gatgaagct  caggatgtc  ttacggggt  ctgacatgt  1440
gaagctgca  agtattctt  aaaagagca  tggaaggac  gcacaatta  ctttgtgct  1500
gaagaaacg  ttgcatcat  gataaaatt  gaaggaaaa  ctgcccagc  tgccgctat  1560
ggaaatgtc  tcaggctgg  atgaacctt  aagctcgaa  aacaaagaa  aaaatcaaa  1620
ggattcagc  agccactgc  ggagtctca  aagacactt  ggaaaatcc  aacaaaaca  1680
tagttcctg  agcattacc  cagctcacc  ctaccttgg  gtcactgct  gaggtgatt  1740
aacccgagg  gttgtatgc  ggatatgat  gctctgttc  agattcagc  tggagaatt  1800
tgaccacac  caacatgtt  ggtgggcgt  aagtgattg  agcagtgaa  tgggcaaag  1860
cgatactag  cttgagaaa  ttacacctc  atgaccaaa  gaccctgct  cagtactca  1920
ggatgtttc  catggcatt  gccttgggt  ggagatcat  cagacaatc  agcggaaac  1980
tgctctgct  tgctcctga  ctgattatt  atgagcaga  aatgtctct  ccctgcatg  2040
atgaccaat  taaacacat  ctgtttgtc  cctctgaat  acaaagatt  caggtatcc  2100
atgaagagt  tctctgtat  aaaacctta  tgcttctct  ctcagttcc  aaggaaggt  2160
tgaagagcc  agagttatt  gatgagatt  gaatgactt  tatcaaaga  ctaggaaaa  2220
ccatcgtca  aagggaagg  aactccagt  agaactggc  acggtttta  caactgaca  2280
agcttctgg  ctccatgca  gaggtggtt  agaatctcc  tacctactg  ttccagaca  2340
ttttggata  gaccatgag  attgaattc  cagagatgt  agctgaaat  atcactaat  2400
agataccaa  atattcaaa  ggaaatatc  aaaagcttc  gtttcatca  aaatgactg  2460
cttactaag  aaggttgcc  taaagaaag  tgaatttat  gcttttact  tacaaactt  2520
tcaatttgt  ttgtagatg  tttgttgtt  tttttgttt  tgtcttgtt  tgttttaaa  2580
acgcagtac  tgtggttta  agagggcca  gacttggcg  cagaagcag  tgagtcaac  2640
ctctgaagt  atgacacag  acacagtga  gtgtattgt  ggtgtatca  agaaactaa  2700
agttacgtg  aggcatggc  actgtcaga  agggaccgc  cctaaacca  cgtgcccaa  2760
tccatgtgg  tcaactttc  gactcagaa  tttacagtt  gctgggtaa  actttctag  2820
ctttctgtt  gtgtatttt  cccatgtat  gttaggatg  tattttgat  tatgcatgc  2880
aacctgaaa  aagtttaca  gtgtatatc  gaaaaggga  gttgtgcct  ttatagcta  2940
tactgtctg  ttttaacaa  ttcctttat  ttcagtgaa  tatgcttgc  cgtttctct  3000
caataattt  tgtattcca  ttattgtac  gctgtttaa  atgggcagc  gcttcacag  3060
tttcctaga  gctaacatt  atttccgtg  gaaaatggg  cggtgcttc  accctgttg  3120
caccagcta  cagaagacc  cagaaattg  ctcagatct  cagtattct  gttaaaaag  3180
tcttactct  tatatatct  cttccatgg  gaattacat  ggctgagca  attacatag  3240
ctgagcaga  taaccgtcc  aactggtgt  gagcaccta  tccagtgac  ttctgggta  3300
accgtggat  atggttaca  aagactggt  ggaaaacag  aactaccaa  aggcccctt  3360
ccatctaat  caccatctc  tcaatgggg  gatagcaac  aagcccgta  atcagctct  3420
tcaggacct  ctggagtgg  ttgcataac  ttttaaaat  tattattcc  gatagccag  3480
tctgataaa  ccgagagat  gtttaatca  accaagtaa  ttctctcat  aaacttacc  3540
ccaactaaa  cgctaatac  gcaagaatg  ctagacacc  attttcaca  ctcacccgc  3600
ccgattggt  tagctctca  ggtggtcag  agaatcagc  actgatttt  gttacttag  3660
atnttcagg  ctcgcattt  tccnnctac  catccctac  tgtgccata  aatttaaca  3720
aagtcctgt  aacttcttc  cattgagaa  tatcatttt  aacaaaaca  aagcagtag  3780
agccctttc  ntgtgcacc  taccnnctt  ctntgactc  aagcttaat  tgcttacta  3840
gccacaaga  atcngattt  nacttaaag  cgccaaatt  tttgtgtaa  agaaaaact  3900
aaaatctaa  attaaaaat  tgaaacttc  aatatattt  tatatttag  tatagtttc  3960
atatatatc  tatcggtat  cactgatct  gggaaaggg  aagggctac  gcagcttta  4020
atgcaattt  ttaactgac  gtaaaatag  tgtatagta  taagaatga  ttttagtga  4080
attgcttta  catgacatg  tatatattt  tcgtagggg  caaagaaat  ttgatggat  4140
tgatagcct  tatgattta  tngtatata  aagcatnca  acaggcctt  acgcgtctt  4200
gaaannaaa  tacctttgt  ctaagctag  gaagggagc  ggaganngg  cccgtgtgt  4260
tnggaggtt  cgaggctcg  atnnaagag  tcnanaggg  atctaattc  ntacctcca  4320
ctaattacc  caccaccca  gatcctgtc  gtgnaggnn  ggttattaa  tcccccgtt  4380
tactaatat  aataggana  aagggtggc  ctcacgtct  ttccaggcg  cgcagtagc  4440
gggttattt  ccatgcagc  tcccgacaa  gttagcaga  ggaggcttt  gcaagtttg  4500
cgtggcgtg  atagaggca  cagcaacat  taaacctaa  gagcccata  gaagccaag  4560
atacactaa  cctccccac  cttcaatag  ccatttcca  gtaagatga  gacatgctt  4620
tgttttctt  gaatgcttt  agaatgttg  tattttcag  attttgcag  aattattta  4680
taaaaaagt  taatttgaa  tctctctaa  agggattgt  cagtttgta  tggtttaaa  4740
tggtctcaa  gtactttaa  ataattgta  cccagctgg  tgtgaaatt  atggtgcct  4800
agaaatacc  cttgaatat  atcaagaca  tgttaagtt  taaaatgag  ttctcaaaa  4860
tagattatt  tacatttat  gaatgttat  tggttaaac  caaaaaagc  catcacaca  4920
aaatctgct  tcagcttgg  tttcaaaaa  agagctcca  aaacgaaaa  ggagaagaa  4980
aagtatata  atgcgttgt  attaacaga  ggcaacaga  attcataaa  ctactaccg  5040
agctttcct  gaagcgtat  aagagccat  ctcctttag  atgtgggga  gaagagagc  5100
gtcatagtt  cgagtacag  gagaagatg  ggtactgtc  ccgtgtgtg  cttcatacc  5160
ttcctaact  tttaggttt  taataactt  agtgagact  ggtgacatg  ctgtatgac  5220
catgaccga  cttgaaaga  atctttaat  actggtagg  caaaaggga  actctggtt  5280
ttttaggcc  tggcttggg  tactgtata  ccagaagaa  ggagacagg  aacttgggg  5340
agggaaggg  acctaggaa  cactgcctt  tgtaggaaa  aacacacca  taagtgaga  5400
tacccaaag  gacaaggcc  cacagtgtg  ggtctaagg  tgagtcagg  tgagctctg  5460
tgggcatgg  gaagccagc  actccagtg  tacagagca  ggcagggca  ggatgggac  5520
agatggatg  ggatcccag  cccagtagt  tgctccctc  tatttacca  gggatgaac  5580
atggagtat  gatctgtca  cactcaagg  tcatggagc  tgagattcc  gttggtcac  5640
ccaacggta  gctgagatt  aatgtgttt  ttatgtgcc  gtttcagtg  tagaaggcg  5700
aacagagtg  acagaagac  ctgcaaacc  gtcagatga  agtcttctc  ttcccaaac  5760
attttcagt  agcctgctc  atcaggact  gtgaccagc  gctaggaca  ggtcggcgc  5820
tctgtctag  atatgcctg  aaggatttt  ttttctgat  aatggctgt  tgaaaatac  5880
ctcctcaat  acctgctta  ctacataga  atttcagtg  gtcaatatt  tattttgta  5940
attaaacaa  ggctatata  tggggacaa  tctatatta  actgtgtat  gcattatta  6000
gaagctttt  nannatttt  tatcacagt  atttttaaa  gtgtaaaaa  ttaaaaatt  6060
gtgantccn  tttaaaaat  aaagttgta  ttttttatt  atgctgaat  acctgtagt  6120
taaaaatcc  tctttctac  tacanagtg  aatgtcaga  ngtaaaatt  tgtgtggaa  6180
tgtttaact  ttatttttc  ttaaatttg  tgtcttggt  ttaccaaac  acacattgt  6240
ctgaattgg  agtaaatgt  agtcagcca  ttacagcaa  gccaaatat  gataaacat  6300
ataataaaa  atctgcttt  tc  6322



<210> 3311
<211> 795
<212> PRT
<213> Rattus norvegicus
<308> P06536
<400> 3311

Met Asp Ser Lys Glu Ser Leu Ala Pro Pro Gly Arg Asp Glu Val Pro 
  1               5                  10                  15
Gly Ser Leu Leu Gly Gln Gly Arg Gly Ser Val Met Asp Phe Tyr Lys 
             20                  25                  30
Ser Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser 
         35                  40                  45
Val Ala Ala Ala Ser Gln Ala Asp Ser Lys Gln Gln Arg Ile Leu Leu 
     50                  55                  60
Asp Phe Ser Lys Gly Ser Thr Ser Asn Val Gln Gln Arg Gln Gln Gln 
 65                  70                  75                  80
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                 85                  90                  95
Pro Asp Leu Ser Lys Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly 
             100                105                110
Glu Thr Glu Thr Lys Val Met Gly Asn Asp Leu Gly Tyr Pro Gln Gln 
         115                120                125
Gly Gln Leu Gly Leu Ser Ser Gly Glu Thr Asp Phe Arg Leu Leu Glu 
     130                135                140
Glu Ser Ile Ala Asn Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro 
 145                150                155                160
Lys Ser Ser Thr Ser Ala Thr Gly Cys Ala Thr Pro Thr Glu Lys Glu 
                 165                170                175
Phe Pro Lys Thr His Ser Asp Ala Ser Ser Glu Gln Gln Asn Arg Lys 
             180                185                190
Ser Gln Thr Gly Thr Asn Gly Gly Ser Val Lys Leu Tyr Pro Thr Asp 
         195                200                205
Gln Ser Thr Phe Asp Leu Leu Lys Asp Leu Glu Phe Ser Ala Gly Ser 
     210                215                220
Pro Ser Lys Asp Thr Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile 
 225                230                235                240
Asp Glu Asn Leu Leu Ser Pro Leu Ala Gly Glu Asp Asp Pro Phe Leu 
                 245                250                255
Leu Glu Gly Asn Thr Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp 
             260                265                270
Thr Lys Pro Lys Ile Lys Asp Thr Gly Asp Thr Ile Leu Ser Ser Pro 
         275                280                285
Ser Ser Val Ala Leu Pro Gln Val Lys Thr Glu Lys Asp Asp Phe Ile 
     290                295                300
Glu Leu Cys Thr Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Pro Val 
 305                310                315                320
Tyr Cys Gln Ala Ser Phe Ser Gly Thr Asn Ile Ile Gly Asn Lys Met 
                 325                330                335
Ser Ala Ile Ser Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr 
             340                345                350
His Tyr Asp Met Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys 
         355                360                365
Pro Val Phe Asn Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp 
     370                375                380
Asn Arg Cys Gln Gly Ser Gly Glu Asp Ser Leu Thr Ser Leu Gly Ala 
 385                390                395                400
Leu Asn Phe Pro Gly Arg Ser Val Phe Ser Asn Gly Tyr Ser Ser Pro 
                 405                410                415
Gly Met Arg Pro Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Ala Ala 
             420                425                430
Thr Gly Pro Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser 
         435                440                445
Gly Cys His Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe 
     450                455                460
Lys Arg Ala Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn 
 465                470                475                480
Asp Cys Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg 
                 485                490                495
Tyr Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr 
             500                505                510
Lys Lys Lys Ile Lys Gly Ile Gln Gln Ala Thr Ala Gly Val Ser Gln 
         515                520                525
Asp Thr Ser Glu Asn Pro Asn Lys Thr Ile Val Pro Ala Ala Leu Pro 
     530                535                540
Gln Leu Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu 
 545                550                555                560
Val Leu Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Ala Trp Arg 
                 565                570                575
Ile Met Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala 
             580                585                590
Val Lys Trp Ala Lys Ala Ile Leu Gly Leu Arg Asn Leu His Leu Asp 
         595                600                605
Asp Gln Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe 
     610                615                620
Ala Leu Gly Trp Arg Ser Tyr Arg Gln Ser Ser Gly Asn Leu Leu Cys 
 625                630                635                640
Phe Ala Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Ser Leu Pro Cys 
                 645                650                655
Met Tyr Asp Gln Cys Lys His Met Leu Phe Val Ser Ser Glu Leu Gln 
             660                665                670
Arg Leu Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu 
         675                680                685
Leu Leu Ser Ser Val Pro Lys Glu Gly Leu Lys Ser Gln Glu Leu Phe 
     690                695                700
Asp Glu Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val 
 705                710                715                720
Lys Arg Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu 
                 725                730                735
Thr Lys Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Thr 
             740                745                750
Tyr Cys Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro 
         755                760                765
Glu Met Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn 
     770                775                780
Gly Asn Ile Lys Lys Leu Leu Phe His Gln Lys 
 785                790                795



<210> 3312
<211> 555
<212> DNA
<213> Homo sapiens
<308> AI472273
<400> 3312

ttttttttt  ttttttttt  ttttttttt  ttttaaacg  gagtcactg  ttttaattt  60
tacccattt  aaaattcct  ggataaaaa  taatgaaaa  gctttttaa  aatgccata  120
ccagtataa  ataaattgg  ccccattat  tagcattta  tatccaaaa  aaaattttg  180
cccccttga  tctatttgt  gttaagcaa  ttatttggg  ggggttttt  cataccccc  240
ttcatcaaa  aataaaatc  tttcaaaca  tttttagag  gaagcaaat  ctttcctga  300
aacctggtc  ctaatcctg  ggggaccag  ttgcttgaa  atagtctgg  aaattacaa  360
actcccccc  aggggttta  agggtcctc  ttacccttt  atttccctt  tgacactaa  420
accagacac  cccccaaaa  aaccctttc  cctacagtt  cagtnaggg  gtgaccagc  480
aagatggaa  tctcactga  ggctaccat  gtttttgga  tttgacaga  aatgtatgt  540
taacaatat  ttcat  555



<210> 3313
<211> 777
<212> PRT
<213> Homo sapiens
<308> NP_000167
<400> 3313

Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
  1               5                  10                  15
Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
             20                  25                  30
Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
         35                  40                  45
Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
     50                  55                  60
Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
 65                  70                  75                  80
Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                 85                  90                  95
Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
             100                105                110
Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
         115                120                125
Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
     130                135                140
Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
 145                150                155                160
Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                 165                170                175
Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
             180                185                190
Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
         195                200                205
Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
     210                215                220
Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
 225                230                235                240
Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                 245                250                255
Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
             260                265                270
Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
         275                280                285
Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
     290                295                300
Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
 305                310                315                320
Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                 325                330                335
Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
             340                345                350
Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
         355                360                365
Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
     370                375                380
Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
 385                390                395                400
Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                 405                410                415
Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
             420                425                430
Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
         435                440                445
Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
     450                455                460
Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
 465                470                475                480
Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                 485                490                495
Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
             500                505                510
Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
         515                520                525
Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
     530                535                540
Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
 545                550                555                560
Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                 565                570                575
Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
             580                585                590
Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
         595                600                605
Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
     610                615                620
Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
 625                630                635                640
Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                 645                650                655
Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
             660                665                670
Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
         675                680                685
Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
     690                695                700
Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
 705                710                715                720
Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                 725                730                735
Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
             740                745                750
Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
         755                760                765
Ile Lys Lys Leu Leu Phe His Gln Lys 
     770                775



<210> 3314
<211> 1457
<212> DNA
<213> Rattus norvegicus
<308> M14656
<400> 3314

gcaagcctc  gcatccttg  ctttgcagt  tcctgcggc  agcattctc  aggaagcca  60
ccaaggacc  actacaacc  tgagactgg  agtggtttg  ctttgcctg  tcggccttg  120
ctcctgtct  ccggtgaaa  tggctgagt  tggcagctc  gaggagaag  cgcattaca  180
caaacactc  gatgctgta  ccacttggc  gaagcctga  ccatctcag  agcagaatc  240
tctagcccc  cagaattct  tgtcctctg  agaaacgga  gactttaag  aagaaactc  300
tccaagcaa  tccaatgaa  gccatgacc  catggacga  gatgacgac  acgatgacg  360
cggagacca  gcagagagc  aggattctg  gaactcgga  gaatctgac  aatctcacc  420
ttccgatga  tctgatgag  ccttcactg  cagcacaca  gcagacgtt  tgactccaa  480
cgcccccac  gtcgatgtc  ctgacggcc  aggtgatag  ttggcttac  gactgaggt  540
aaagtccag  agtttccct  tttctgatg  acagtatcc  gatgccaca  atgaggacc  600
cacctcccg  atgaagagc  aggagtccg  tgaggctat  aaggtcatc  cagttgccc  660
gcgtctgag  gtgccctct  atcaggaca  caacgggaa  accagccat  agtcaagtc  720
gctggatga  ccaagcgtg  aaacacaca  cctggagca  tccaaggag  ataagcaga  780
ggccagcca  gagagcact  agcagtcgg  tgcgatcga  agtgccgag  agccggatg  840
aatcgatag  gcagagcgg  cggatgcta  cgacagtca  gcgagttcc  aagccagcc  900
ggaacatca  agccacgag  ttcacagcc  tgaggacaa  ctagtccta  accctaaga  960
taaggaaga  gataggtat  tgaaattcc  catttctca  gaattagag  gttcatctt  1020
tgaggtcaa  taaagaaga  gcaaaacca  agttcctta  tttgcttta  ataaaacaa  1080
aagtaaatt  caacaagca  gaatactaa  tgcttgttt  tcagttcag  ggatacatg  1140
atgtggaga  agaaataga  agtgttttg  gccctgagc  tagttcgtt  tttcatgca  1200
acaccactg  aacctagaa  tttcagcat  tcgcttctg  tctttctgt  caagaaatg  1260
aaatggcca  tgcatttta  tgattgcta  tcttttatg  ataaaatgt  tgtagaggc  1320
ggcaaactt  caggaacag  aaaattaaa  gagaaacta  aatagtctg  gtcactata  1380
tcttttggt  ttataatta  tgtatattt  gttgtgatt  tttttgttg  tgtgaataa  1440
tcttgtatc  tgaatgt  1457



<210> 3315
<211> 317
<212> PRT
<213> Rattus norvegicus
<308> P08721
<400> 3315

Met Arg Leu Ala Val Val Cys Phe Cys Leu Phe Gly Leu Ala Ser Cys 
  1               5                  10                  15
Leu Pro Val Lys Val Ala Glu Phe Gly Ser Ser Glu Glu Lys Ala His 
             20                  25                  30
Tyr Ser Lys His Ser Asp Ala Val Ala Thr Trp Leu Lys Pro Asp Pro 
         35                  40                  45
Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ser Val Ser Ser Glu 
     50                  55                  60
Glu Thr Asp Asp Phe Lys Gln Glu Thr Leu Pro Ser Asn Ser Asn Glu 
 65                  70                  75                  80
Ser His Asp His Met Asp Asp Asp Asp Asp Asp Asp Asp Asp Gly Asp 
                 85                  90                  95
His Ala Glu Ser Glu Asp Ser Val Asn Ser Asp Glu Ser Asp Glu Ser 
             100                105                110
His His Ser Asp Glu Ser Asp Glu Ser Phe Thr Ala Ser Thr Gln Ala 
         115                120                125
Asp Val Leu Thr Pro Ile Ala Pro Thr Val Asp Val Pro Asp Gly Arg 
     130                135                140
Gly Asp Ser Leu Ala Tyr Gly Leu Arg Ser Lys Ser Arg Ser Phe Pro 
 145                150                155                160
Val Ser Asp Glu Gln Tyr Pro Asp Ala Thr Asp Glu Asp Leu Thr Ser 
                 165                170                175
Arg Met Lys Ser Gln Glu Ser Asp Glu Ala Ile Lys Val Ile Pro Val 
             180                185                190
Ala Gln Arg Leu Ser Val Pro Ser Asp Gln Asp Ser Asn Gly Lys Thr 
         195                200                205
Ser His Glu Ser Ser Gln Leu Asp Glu Pro Ser Val Glu Thr His Ser 
     210                215                220
Leu Glu Gln Ser Lys Glu Tyr Lys Gln Arg Ala Ser His Glu Ser Thr 
 225                230                235                240
Glu Gln Ser Asp Ala Ile Asp Ser Ala Glu Lys Pro Asp Ala Ile Asp 
                 245                250                255
Ser Ala Glu Arg Ser Asp Ala Ile Asp Ser Gln Ala Ser Ser Lys Ala 
             260                265                270
Ser Leu Glu His Gln Ser His Glu Phe His Ser His Glu Asp Lys Leu 
         275                280                285
Val Leu Asp Pro Lys Ser Lys Glu Asp Asp Arg Tyr Leu Lys Phe Arg 
     290                295                300
Ile Ser His Glu Leu Glu Ser Ser Ser Ser Glu Val Asn 
 305                310                315



<210> 3316
<211> 1424
<212> DNA
<213> Homo sapiens
<308> X13694
<400> 3316

gaccagact  gtctcaggc  agttgcagc  ttctcagcc  aacgccgac  aaggaaaac  60
cactaccat  agaattgca  tgatttgct  ttgcctcct  ggcatcacc  gtgccatac  120
agttaaaca  gctgattct  gaagttctg  ggaaaagca  ctttacaac  aatacccag  180
tgctgtggc  acatggcta  accctgacc  atctcagaa  cagaatctc  tagccccac  240
gaatgctgt  tcctctgaa  aaaccaatg  ctttaaaca  gagaccctt  caagtaagt  300
caacgaaag  catgaccac  tggatgata  ggatgatga  gatgatgat  accatgtgg  360
cagccagga  tccattgac  cgaacgact  tgatgatgt  gatgacact  atgattctc  420
ccagtctga  gagtctcac  attctgatg  atctgatga  ctggtcact  attttccca  480
ggacctgcc  gcaaccgaa  ttttcactc  agttgtccc  acagtagac  catatgatg  540
ccgaggtga  agtgtggtt  atggactga  gtcaaaatc  aagaagttt  gcagacctg  600
catccagta  cctgatgct  cagacgagg  catcacctc  cacatggaa  gcgaggagt  660
gaatggtgc  tacaaggcc  tccccgttg  ccaggacct  aacgcgcct  ctgattggg  720
cagccgtgg  aaggacagt  atgaaacga  tcagctgga  gaccagagt  ctgaaaccc  780
cagccacaa  cagtccaga  tatataagc  gaaagccaa  gatgagagc  atgagcatt  840
cgatgtgat  gatagtcag  aactttcca  agtcagccg  gaattccac  gccatgaat  900
tcacagcca  gaagatatg  tggttgtag  ccccaaaag  aaggaagaa  ataaacacc  960
gaaatttcg  atttctcat  aattagata  tgcatcttc  gaggtcaat  aaaaggaga  1020
aaaatacaa  ttctcactt  gcatttagt  aaaagaaaa  atgctttat  gcaaaatga  1080
agagaacat  aaatgcttc  ttctcagtt  attggttga  tgtgtatct  tttgagtct  1140
gaaataact  atgtgtttg  taattagtt  agtttgtgg  ttcatggaa  ctccctgta  1200
actaaaagc  tcagggtta  gtctatgtt  attctatag  agaaatgca  actatcact  1260
tattttaat  tttgttatt  tctcatgaa  agaaattta  gtagaagca  acaaaatac  1320
tttacccac  taaaaagag  atataacat  ttatgtcac  ataatcttt  gttttttaa  1380
ttagtgtat  ttttgttgt  attatcttt  tgtggtgtg  ataa  1424



<210> 3317
<211> 314
<212> PRT
<213> Homo sapiens
<308> P10451
<400> 3317

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
  1               5                  10                  15
Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
             20                  25                  30
Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
         35                  40                  45
Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
     50                  55                  60
Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
 65                  70                  75                  80
Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                 85                  90                  95
Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
             100                105                110
Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
         115                120                125
Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
     130                135                140
Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
 145                150                155                160
Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                 165                170                175
Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
             180                185                190
Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
         195                200                205
Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
     210                215                220
Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
 225                230                235                240
Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                 245                250                255
His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
             260                265                270
Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
         275                280                285
Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
     290                295                300
Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
 305                310



<210> 3318
<211> 657
<212> DNA
<213> Rattus norvegicus
<308> M15474
<400> 3318

gaaggctgg  ccatgtcag  cttgagtct  ggcagtagt  gctgaggaa  gcctcccct  60
ggtgcagct  gcagtgggt  tcacatggc  tcctaccgg  ttgcatgtc  aacacactg  120
tatcatctg  ttggttttc  tcctttttc  cttttccat  gctccactt  ttctctccc  180
ccttttatt  caccacaga  aagtttctt  gcttctctc  tcccaagac  ccttcatca  240
gccggatgt  ccacctctc  gagctctgc  tctgtctgc  ctccagctg  cccagtttc  300
ttctagtgc  cacccaccc  agggccagc  cagaccgtg  tttcttatt  tcacagagg  360
gatcctccc  gtgtaaaat  aacactgta  gccagtcct  tttgctatt  ctttgcccc  420
cattcattg  catttccgt  tcagcgccc  ataaaacta  agttctgct  tgtgcatct  480
agggtactt  ttttttttt  ttttacatt  tataccccc  cgagttttt  atcgcagta  540
ttccgtgta  aacttttta  aatgctacc  acatgtgcc  ctctgagtt  tggttcctg  600
gctggagtg  ggcccaagt  gctatggct  taggaattg  gacagttct  acatgca  657



<210> 3319
<211> 284
<212> PRT
<213> Rattus norvegicus
<308> AAA21801
<400> 3319

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
  1               5                  10                  15
Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
             20                  25                  30
Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
         35                  40                  45
Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
     50                  55                  60
Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
 65                  70                  75                  80
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                 85                  90                  95
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
             100                105                110
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
         115                120                125
Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
     130                135                140
Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
 145                150                155                160
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                 165                170                175
Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
             180                185                190
Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
         195                200                205
Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu 
     210                215                220
Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
 225                230                235                240
Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                 245                250                255
Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
             260                265                270
Glu Leu Asp His Ala Leu Lys Asp Met Thr Ser Ile 
         275                280



<210> 3320
<211> 1633
<212> DNA
<213> Homo sapiens
<308> NM_000366
<400> 3320

cagaatctc  ggcagtttt  gtacctcaa  aagtaagtg  aacaccttt  cctgtcata  60
ttattttca  ccagacatc  ggtggaagc  tcagattcc  tacagatat  agagaggca  120
catttaaaa  gtagaacag  atcgacaaa  aaggattta  gtcaggatc  ctcagcctc  180
gtgttaccg  gggcatttc  aacagtctt  ttactacgg  ctccgccga  cgcgcgctc  240
ccccgccgc  cctgctgca  ccccagggc  cctcgccgc  gccaccatg  acgccatca  300
gaagaagat  cagatgctg  agctcgaca  ggagaacgc  ttggatcga  ctgagcagg  360
ggaggccga  aagaaggcg  cggaagaca  gagcaagca  ctggaagat  agctggtgt  420
actgcaaaa  aaactcaag  gcaccgaag  tgaactgga  aaatactct  aggctctca  480
agatgccca  gagaagctg  agctggcag  gaaaaaggc  accgatgct  aagccgacg  540
agcttctct  aacagacgc  tccagctgg  tgaggaaga  ttggatcgt  cccaggagc  600
tctggcaac  gctttgcag  agctggagg  agctgagaa  gcagcagat  agagtgaga  660
aggcatgaa  gtcattgag  gtcgagccc  aaaagatga  gaaaaaatg  aaattcagg  720
gatccaact  aaagaggca  agcacattg  tgaagatgc  gaccgcaaa  atgaagagg  780
ggcccgtaa  ctggtcatc  ttgagagcg  cctggaacg  gcagaggag  gggctgagc  840
ctcagaagg  caagtccga  agctggaag  acaattaag  ataatggat  agaccttga  900
agcattaat  gctgcagag  ataagtact  gcagaagga  gacagatat  aggaagaga  960
caaggtcct  tccgacaag  tgaaggagg  tgagactcg  gctgagttt  cggagaggt  1020
agtaactaa  ttggagaaa  gcattgatg  cttagaaga  aaagtggct  atgccaaag  1080
agaaaacct  agtatgcat  agatgctgg  tcagacttt  ctggagtta  acaacatgt  1140
aaaacctcc  tagctgcga  cacattctt  cattttgtt  tgttttgtt  tgtttttaa  1200
cacctgctt  ccccttaaa  gcaatttat  tacttttac  actgtcaca  aaacatcca  1260
aagatacca  ctaggtcag  gggtgggga  aacacatac  aaaagcaag  ccatgtcag  1320
gcgatcctg  ttcaaatgt  ccatttccc  ggttgatgc  gccacactt  gtagagagt  1380
tagcaacac  gtgtgctta  tcagcgtag  aatcctcac  aaagcagga  aagttccat  1440
caaagtgcc  atgatagag  caacaagga  ggttaatgt  ggaaacaca  tcaggtgtg  1500
attggtgct  ctttgaaca  aaggtcccc  tgtggtctt  tgttcaaca  tgtacaatg  1560
agaactctg  ccaacacta  tttattttg  cttgagttt  actacaaga  gagactatg  1620
atcccgcat  cct  1633



<210> 3321
<211> 284
<212> PRT
<213> Homo sapiens
<308> P09493
<400> 3321

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
  1               5                  10                  15
Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
             20                  25                  30
Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
         35                  40                  45
Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
     50                  55                  60
Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
 65                  70                  75                  80
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                 85                  90                  95
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
             100                105                110
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
         115                120                125
Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
     130                135                140
Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
 145                150                155                160
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                 165                170                175
Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
             180                185                190
Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
         195                200                205
Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
     210                215                220
Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
 225                230                235                240
Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                 245                250                255
Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
             260                265                270
Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
         275                280



<210> 3322
<211> 657
<212> DNA
<213> Rattus norvegicus
<308> M15474
<400> 3322

gaaggctgg  ccatgtcag  cttgagtct  ggcagtagt  gctgaggaa  gcctcccct  60
ggtgcagct  gcagtgggt  tcacatggc  tcctaccgg  ttgcatgtc  aacacactg  120
tatcatctg  ttggttttc  tcctttttc  cttttccat  gctccactt  ttctctccc  180
ccttttatt  caccacaga  aagtttctt  gcttctctc  tcccaagac  ccttcatca  240
gccggatgt  ccacctctc  gagctctgc  tctgtctgc  ctccagctg  cccagtttc  300
ttctagtgc  cacccaccc  agggccagc  cagaccgtg  tttcttatt  tcacagagg  360
gatcctccc  gtgtaaaat  aacactgta  gccagtcct  tttgctatt  ctttgcccc  420
cattcattg  catttccgt  tcagcgccc  ataaaacta  agttctgct  tgtgcatct  480
agggtactt  ttttttttt  ttttacatt  tataccccc  cgagttttt  atcgcagta  540
ttccgtgta  aacttttta  aatgctacc  acatgtgcc  ctctgagtt  tggttcctg  600
gctggagtg  ggcccaagt  gctatggct  taggaattg  gacagttct  acatgca  657



<210> 3323
<211> 284
<212> PRT
<213> Rattus norvegicus
<308> AAA21801
<400> 3323

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
  1               5                  10                  15
Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
             20                  25                  30
Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
         35                  40                  45
Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
     50                  55                  60
Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
 65                  70                  75                  80
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                 85                  90                  95
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
             100                105                110
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
         115                120                125
Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
     130                135                140
Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
 145                150                155                160
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                 165                170                175
Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
             180                185                190
Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
         195                200                205
Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu 
     210                215                220
Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
 225                230                235                240
Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                 245                250                255
Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
             260                265                270
Glu Leu Asp His Ala Leu Lys Asp Met Thr Ser Ile 
         275                280



<210> 3324
<211> 1633
<212> DNA
<213> Homo sapiens
<308> NM_000366
<400> 3324

cagaatctc  ggcagtttt  gtacctcaa  aagtaagtg  aacaccttt  cctgtcata  60
ttattttca  ccagacatc  ggtggaagc  tcagattcc  tacagatat  agagaggca  120
catttaaaa  gtagaacag  atcgacaaa  aaggattta  gtcaggatc  ctcagcctc  180
gtgttaccg  gggcatttc  aacagtctt  ttactacgg  ctccgccga  cgcgcgctc  240
ccccgccgc  cctgctgca  ccccagggc  cctcgccgc  gccaccatg  acgccatca  300
gaagaagat  cagatgctg  agctcgaca  ggagaacgc  ttggatcga  ctgagcagg  360
ggaggccga  aagaaggcg  cggaagaca  gagcaagca  ctggaagat  agctggtgt  420
actgcaaaa  aaactcaag  gcaccgaag  tgaactgga  aaatactct  aggctctca  480
agatgccca  gagaagctg  agctggcag  gaaaaaggc  accgatgct  aagccgacg  540
agcttctct  aacagacgc  tccagctgg  tgaggaaga  ttggatcgt  cccaggagc  600
tctggcaac  gctttgcag  agctggagg  agctgagaa  gcagcagat  agagtgaga  660
aggcatgaa  gtcattgag  gtcgagccc  aaaagatga  gaaaaaatg  aaattcagg  720
gatccaact  aaagaggca  agcacattg  tgaagatgc  gaccgcaaa  atgaagagg  780
ggcccgtaa  ctggtcatc  ttgagagcg  cctggaacg  gcagaggag  gggctgagc  840
ctcagaagg  caagtccga  agctggaag  acaattaag  ataatggat  agaccttga  900
agcattaat  gctgcagag  ataagtact  gcagaagga  gacagatat  aggaagaga  960
caaggtcct  tccgacaag  tgaaggagg  tgagactcg  gctgagttt  cggagaggt  1020
agtaactaa  ttggagaaa  gcattgatg  cttagaaga  aaagtggct  atgccaaag  1080
agaaaacct  agtatgcat  agatgctgg  tcagacttt  ctggagtta  acaacatgt  1140
aaaacctcc  tagctgcga  cacattctt  cattttgtt  tgttttgtt  tgtttttaa  1200
cacctgctt  ccccttaaa  gcaatttat  tacttttac  actgtcaca  aaacatcca  1260
aagatacca  ctaggtcag  gggtgggga  aacacatac  aaaagcaag  ccatgtcag  1320
gcgatcctg  ttcaaatgt  ccatttccc  ggttgatgc  gccacactt  gtagagagt  1380
tagcaacac  gtgtgctta  tcagcgtag  aatcctcac  aaagcagga  aagttccat  1440
caaagtgcc  atgatagag  caacaagga  ggttaatgt  ggaaacaca  tcaggtgtg  1500
attggtgct  ctttgaaca  aaggtcccc  tgtggtctt  tgttcaaca  tgtacaatg  1560
agaactctg  ccaacacta  tttattttg  cttgagttt  actacaaga  gagactatg  1620
atcccgcat  cct  1633



<210> 3325
<211> 284
<212> PRT
<213> Homo sapiens
<308> P09493
<400> 3325

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
  1               5                  10                  15
Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
             20                  25                  30
Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
         35                  40                  45
Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
     50                  55                  60
Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
 65                  70                  75                  80
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                 85                  90                  95
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
             100                105                110
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
         115                120                125
Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
     130                135                140
Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
 145                150                155                160
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                 165                170                175
Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
             180                185                190
Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
         195                200                205
Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
     210                215                220
Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
 225                230                235                240
Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                 245                250                255
Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
             260                265                270
Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
         275                280



<210> 3326
<211> 1346
<212> DNA
<213> Rattus norvegicus
<308> M15481
<400> 3326

gaattccgg  agacaacct  gtcaagcac  taattgtgc  atccgtgcg  tgccagcca  60
ctccatcca  cttacagga  tgaagtcag  gttcatata  gctgtgtgg  ctggcagct  120
agatagtgt  tcccaaagg  actgtggaa  gttacctca  caggcattc  tttcgcgtt  180
ggaaaatcg  ctccaaatg  actttcttt  cgtgctggg  ctgcagaac  tttcagaag  240
ggagctagc  atctgcttc  acttttttt  ccccggtgc  tgcagcagg  gatgcctga  300
gggagctgc  gcgtggtgg  ctgaaacat  gttcaagga  tagaggtca  ctgcctaga  360
cggtgcagg  agggcacag  ctggctttg  actctgagt  tcaaggtat  tcccagtgc  420
tgagccagg  ggaaggtgg  gggaggaag  gaaggagct  ccacttgga  cgctattct  480
ggtagccaa  acagatagc  atacaatgg  aattagtgg  ttcaacttg  gggaaagga  540
ggactctaa  ttcgagctg  gcagttcgc  cattgtttg  atggacaaa  ggcagttta  600
ccaggctcc  agcatacct  cctgggtgt  caaatgtaa  tagatgctt  cacaaaccc  660
acccacaaa  caacacatg  tcttaagtc  tgggctttg  tttcacttc  gcctcataa  720
acccactct  acctgctgt  taaacgacc  gggacgtac  aaaatgagc  cacctccaa  780
aaagataca  atcatgtcg  cttcacatc  cttctacct  gcactctgc  tgctcacct  840
taccagctc  gccacagcc  gaccagaga  cctttgcgg  gctgagctg  tggacgctc  900
tcagttcgt  tgtggacca  ggggctttt  cttcaacaa  cccacaggc  atggctcca  960
cattcggag  gcaccacag  cgggcattg  ggatgagtg  tgcttccgg  gctgtgatc  1020
gaggaggct  gagatgtac  gtgtccgct  caagcctac  aagtcagct  gttccatcc  1080
ggcccagcg  cacactgac  tgcccaaga  tcagaagga  gtacacttg  agaacacaa  1140
tagaggaag  gcaggaaac  agacctaca  aatgtagga  gagcctccc  aggaacaga  1200
aatgccacg  caccgcaag  tcctttgct  cttgagcaa  ctgcaaaac  tcggaacac  1260
tgccaaata  caataatga  ttcaatacc  tttcagaga  gggcatttc  ctcaatgaa  1320
tacacaagt  aacattccc  gaattc  1346



<210> 3327
<211> 181
<212> PRT
<213> Rattus norvegicus
<308> P08024
<400> 3327

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Ile Cys Leu 
  1               5                  10                  15
Cys Asp Phe Leu Lys Ile Lys Ile His Ile Met Ser Ser Ser His Leu 
             20                  25                  30
Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
         35                  40                  45
Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
     50                  55                  60
Val Cys Gly Pro Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
 65                  70                  75                  80
Ser Ser Ile Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                 85                  90                  95
Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
             100                105                110
Lys Pro Thr Lys Ser Ala Arg Ser Ile Arg Ala Gln Arg His Thr Asp 
         115                120                125
Met Pro Lys Thr Gln Lys Ser Gln Pro Leu Ser Thr His Lys Lys Arg 
     130                135                140
Lys Leu Gln Arg Arg Arg Lys Gly Glu Ser Lys Ala His Pro Gly Gly 
 145                150                155                160
Glu Gln Glu Glu Gly Ala Glu Ala Thr Gln Lys Ile Arg Gly Asp Arg 
                 165                170                175
Glu Arg Arg Pro Ser 
             180



<210> 3329
<211> 240
<212> PRT
<213> Rattus norvegicus
<308> AAA41877
<400> 3329

Gln Gly Gln Ala Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys 
  1               5                  10                  15
Val Leu Gly Lys Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys 
             20                  25                  30
Gly Lys Asp Glu Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile 
         35                  40                  45
Leu Gln Asp Gly Gln Arg Gly Leu His Asp Asp Arg Glu Glu Asp Phe 
     50                  55                  60
Gly Ser Gly Ala Glu Thr Pro Leu Ser Asn Pro Thr Leu Leu Leu Leu 
 65                  70                  75                  80
Pro Asp Gln Gly Pro Pro Leu Leu Arg Gln Glu Tyr Val Asn Gly Gly 
                 85                  90                  95
Asp Leu Met Phe Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg 
             100                105                110
Ser Gly Phe Tyr Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His 
         115                120                125
Gln His Gly Val Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu 
     130                135                140
Asp Ala Glu Gly His Cys Lys Leu Ala Asp Phe Gly Met Cys Lys Glu 
 145                150                155                160
Gly Ile Leu Asn Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp 
                 165                170                175
Tyr Ile Ala Pro Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val 
             180                185                190
Asp Trp Trp Ala Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln 
         195                200                205
Pro Pro Phe Glu Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu 
     210                215                220
His Asp Asp Val Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser 
 225                230                235                240



<210> 3330
<211> 2244
<212> DNA
<213> Homo sapiens
<308> NM_005400
<400> 3330

ctccccgcc  cgaccatgg  agtgttcaa  ggccttctt  agatcaaaa  ctgcgaggc  780
gtgagcttg  agcccacag  ctggtcgct  cgccatgcg  tgggacccc  gccgcagac  840
ttccttctc  acccctaca  tgccctcaa  gtggacgac  cgcgcatcg  ccaaacggc  900
accaagcag  agaccaaca  cccggcctg  cacgacgag  tcgtcaccg  tgtgtgcaa  960
ggacgcaag  tcgagctgg  tgtctttca  gatgccccc  taggctacg  cgacttcgt  1020
gccaactgc  ccatccagt  tgaggagct  ctgcagaac  ggagccgcc  cttcgagga  1080
tggattgat  tggagccag  aggaagagt  tatgtgatc  tcgatctct  agggtcgtc  1140
ggtgaagcc  ctaaagaca  tgaagagcg  gtgttcagg  aacgcatgc  gccgaggaa  1200
cggcagggg  ccgtcaggc  cagggtcca  caggtcaac  gccacaagt  catggccac  1260
tatcttcgg  agcccacct  ctgctccca  tgcagagac  tcatctggg  tgtcatagg  1320
aagcaggga  accagtgtc  agtctgcac  tgcgtggtc  acaagcggt  ccacgagct  1380
ataatcaca  agtgtgctg  gttaaagaa  caggagacc  ccgaccagg  gggctccca  1440
cggttcagc  tcaacatgc  ccacaagtt  ggtatccac  actacaagg  ccctacctt  1500
tgcgatcac  gtgggtccc  gctctgggg  ctcttgcgg  agggtttgc  gtgtaaagt  1560
tgcaaaatg  atgttcacc  tcgatgtga  accaacgtg  ctcccaact  tggagtgga  1620
gccagagga  tcgccaaag  actggccga  ctgggcgtt  ccccagaca  aatcaccaa  1680
agcggccag  gaaggaaaa  gctcattgc  ggtgccgag  ccccgcagc  tgcttctgg  1740
agctcacca  ctgaggaag  tcgatccaa  tcagcaccc  cctcccctt  tgaccagga  1800
ataaaagaa  ttgagaaca  cattcggaa  gccttgtca  ttgacaacc  aggagagga  1860
caccgggca  catcgtctc  tgatggcca  ctgatgagc  ccggtgaga  tggcgaagt  1920
cggcaaggc  aggccaagc  cctgggcct  gatgagttc  acttcatca  ggtgttggg  1980
aaaggcagc  ttggcaagg  catgttggc  gaactcaag  gcaaagatg  agtatatgc  2040
gtgaaggtc  taaagaagg  cgtcatcct  caggatgat  acgtggact  cacaatgac  2100
gagaagagg  ttttggctc  ggcacggaa  cacccgtac  ttacccaac  ctactgctg  2160
ttccagacc  aggaccgcc  ctttttcgt  atggaatat  taaatggtg  agacctcat  2220
tttcagatt  agcgctccc  aaaa  2244



<210> 3331
<211> 737
<212> PRT
<213> Homo sapiens
<308> Q02156
<400> 3331

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
  1               5                  10                  15
Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
             20                  25                  30
Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
         35                  40                  45
Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
     50                  55                  60
Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
 65                  70                  75                  80
Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                 85                  90                  95
Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
             100                105                110
Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Arg Val Tyr Val Ile 
         115                120                125
Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
     130                135                140
Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
 145                150                155                160
Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                 165                170                175
Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
             180                185                190
Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
         195                200                205
His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
     210                215                220
Lys Gln Glu Thr Pro Asp Gln Val Gly Ser Gln Arg Phe Ser Val Asn 
 225                230                235                240
Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                 245                250                255
Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
             260                265                270
Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
         275                280                285
Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
     290                295                300
Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
 305                310                315                320
Lys Lys Leu Ile Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Ser 
                 325                330                335
Ser Pro Ser Glu Glu Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
             340                345                350
Asp Gln Glu Ile Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
         355                360                365
Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ala Ser Ser Pro Asp Gly 
     370                375                380
Gln Leu Met Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
 385                390                395                400
Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                 405                410                415
Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
             420                425                430
Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
         435                440                445
Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
     450                455                460
Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
 465                470                475                480
Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                 485                490                495
Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Arg Phe Tyr 
             500                505                510
Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
         515                520                525
Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
     530                535                540
His Cys Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
 545                550                555                560
Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                 565                570                575
Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
             580                585                590
Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
         595                600                605
Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
     610                615                620
Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
 625                630                635                640
Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ser Gln 
                 645                650                655
Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
             660                665                670
Trp Val Leu Leu Glu Gln Lys Lys Ile Lys Pro Pro Phe Lys Pro Arg 
         675                680                685
Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
     690                695                700
Glu Glu Pro Val Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
 705                710                715                720
Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                 725                730                735
Pro 
             740



<210> 3332
<211> 805
<212> DNA
<213> Rattus norvegicus
<308> M15562
<400> 3332

gtgattcca  aggtgactg  actccccaa  agcccggtg  acctgggag  gcccaacat  60
ctcatctgt  tcattgaca  gttctcccc  ccagcggtc  atgtcacct  gcttcggaa  120
ggacagcct  tcaccaaag  cgtgtcaga  acagtgttt  tcccaaggg  ggaccacct  180
ttccgcaaa  tccactatc  caccttcct  ccctccgtg  aagattact  tgactgtga  240
gtggatcac  ggggtctgg  ggagcctct  cggaagcac  gggagtttg  agagaaaac  300
ctcctccca  aaactaaag  gaatgtcct  tgtgttctc  ggttgtttg  gggtctggt  360
ggcatcgtc  tcgggattg  gctcatcat  aagggcctt  ggaaacgca  cgcagtgga  420
cgccaagga  ccctgtgag  taccgggag  tgatggctt  cgtgagagc  catagaaga  480
atgtgctgt  acagcatct  aggctaccc  ttctctcag  tcttcacct  agcagagac  540
tcttctgca  tttccaacc  caagcctcg  gccagattc  ctggtctaa  gtctggctg  600
ggttctccg  ctgcttcct  tatctatat  ctattttcc  tcatttata  taattcctc  660
gtggcacat  tcacagagc  cttcctccg  tgcggaact  tctaagaat  gaggcatct  720
ctgttcact  acggcttga  atttctcca  actgtgttt  ctctttctc  ttttcaata  780
ataataaac  ccttgggtc  tgaat  805



<210> 3333
<211> 145
<212> PRT
<213> Rattus norvegicus
<308> AAA41609
<400> 3333

Val Ile Pro Glu Val Thr Val Leu Pro Lys Ser Pro Val Asn Leu Gly 
  1               5                  10                  15
Glu Pro Asn Ile Leu Ile Cys Phe Ile Asp Lys Phe Ser Pro Pro Ala 
             20                  25                  30
Val Asn Val Thr Trp Leu Arg Asn Gly Gln Pro Val Thr Lys Gly Val 
         35                  40                  45
Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe 
     50                  55                  60
His Tyr Leu Thr Phe Leu Pro Ser Val Glu Asp Tyr Tyr Asp Cys Glu 
 65                  70                  75                  80
Val Asp His Trp Gly Leu Glu Glu Pro Leu Arg Lys His Trp Glu Phe 
                 85                  90                  95
Glu Glu Lys Thr Leu Leu Pro Glu Thr Lys Glu Asn Val Leu Cys Val 
             100                105                110
Leu Gly Leu Phe Val Gly Leu Val Gly Ile Val Val Gly Ile Val Leu 
         115                120                125
Ile Ile Lys Gly Leu Arg Lys Arg Asn Ala Val Glu Arg Gln Gly Ala 
     130                135                140
Leu 
 145



<210> 3334
<211> 819
<212> DNA
<213> Homo sapiens
<308> M60334
<400> 3334

actcccaaa  gagcgccca  gaagaaaat  gccataagt  gagtccctg  gctaggatt  60
ttcatcata  ctgtgctga  gagcgctca  gaatcatgg  ctatcaaag  agaacatgt  120
atcatccag  ccgagttct  tctgaatcc  gaccaatca  gcgagttta  gtttgactt  180
gatggtgat  agattttcc  tgtggatat  gcaaagaag  agacggtct  gcggcttga  240
gaatttgga  gatttgcca  ctttgaggc  caaggtgca  tggccaaca  agctgtgga  300
aaagccaac  tggaaatca  gacaaagcg  tccaactat  ctccgatca  caatgtacc  360
ccagaggta  ctgtgctca  gaacagccc  gtggaactg  gagagccca  cgtcctcat  420
tgtttcata  acaagttca  cccaccagt  gtcaatgtc  cgtggcttc  aaatggaaa  480
cctgtcacc  caggagtgt  agagacagt  ttcctgccc  gggaagacc  ccttttccg  540
aagttccac  atctcccct  cctgccctc  actgaggac  tttacgact  cagggtgga  600
cactggggc  tggatgagc  tcttctcaa  cactgggag  ttgatgctc  aagccctct  660
ccagagact  cagagaacg  ggtgtgtgc  ctgggcctg  ctgtgggtc  ggtgggcat  720
attattggg  ccatcttca  catcaaggg  ttgcgcaaa  gcaatgcag  agaacgcag  780
gggcctctg  aaggcacat  gaggtgatg  tgtttctta  819



<210> 3335
<211> 254
<212> PRT
<213> Homo sapiens
<308> P01903
<400> 3335

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
  1               5                  10                  15
Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
             20                  25                  30
Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
         35                  40                  45
Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
     50                  55                  60
Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
 65                  70                  75                  80
Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                 85                  90                  95
Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
             100                105                110
Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
         115                120                125
Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
     130                135                140
Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
 145                150                155                160
Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                 165                170                175
Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
             180                185                190
Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
         195                200                205
Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
     210                215                220
Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
 225                230                235                240
Gly Val Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                 245                250



<210> 3336
<211> 805
<212> DNA
<213> Rattus norvegicus
<308> M15562
<400> 3336

gtgattcca  aggtgactg  actccccaa  agcccggtg  acctgggag  gcccaacat  60
ctcatctgt  tcattgaca  gttctcccc  ccagcggtc  atgtcacct  gcttcggaa  120
ggacagcct  tcaccaaag  cgtgtcaga  acagtgttt  tcccaaggg  ggaccacct  180
ttccgcaaa  tccactatc  caccttcct  ccctccgtg  aagattact  tgactgtga  240
gtggatcac  ggggtctgg  ggagcctct  cggaagcac  gggagtttg  agagaaaac  300
ctcctccca  aaactaaag  gaatgtcct  tgtgttctc  ggttgtttg  gggtctggt  360
ggcatcgtc  tcgggattg  gctcatcat  aagggcctt  ggaaacgca  cgcagtgga  420
cgccaagga  ccctgtgag  taccgggag  tgatggctt  cgtgagagc  catagaaga  480
atgtgctgt  acagcatct  aggctaccc  ttctctcag  tcttcacct  agcagagac  540
tcttctgca  tttccaacc  caagcctcg  gccagattc  ctggtctaa  gtctggctg  600
ggttctccg  ctgcttcct  tatctatat  ctattttcc  tcatttata  taattcctc  660
gtggcacat  tcacagagc  cttcctccg  tgcggaact  tctaagaat  gaggcatct  720
ctgttcact  acggcttga  atttctcca  actgtgttt  ctctttctc  ttttcaata  780
ataataaac  ccttgggtc  tgaat  805



<210> 3337
<211> 255
<212> PRT
<213> Rattus norvegicus
<308> CAA68540
<400> 3337

Met Ala Thr Ile Gly Asp Leu Val Ile Arg Phe Phe Phe Met Ala Val 
  1               5                  10                  15
Leu Met Ser Pro Gln Lys Ser Trp Ala Ile Lys Glu Glu His Thr Ile 
             20                  25                  30
Ile Gln Ala Glu Phe Tyr Leu Ser Pro Asp Gln Asn Gly Glu Phe Met 
         35                  40                  45
Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Ile Lys Lys Ser 
     50                  55                  60
Glu Thr Ile Trp Arg Leu Glu Glu Phe Ala Lys Phe Ala Ser Phe Glu 
 65                  70                  75                  80
Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Asp 
                 85                  90                  95
Ile Met Ile Lys Arg Ser Asn Asn Thr Pro Asp Ala Asn Val Ile Pro 
             100                105                110
Glu Val Thr Val Leu Pro Lys Ser Pro Val Asn Leu Gly Glu Pro Asn 
         115                120                125
Ile Leu Ile Cys Phe Ile Asp Lys Phe Ser Pro Pro Ala Val Asn Val 
     130                135                140
Thr Trp Leu Arg Asn Gly Gln Pro Val Thr Lys Gly Val Ser Glu Thr 
 145                150                155                160
Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                 165                170                175
Thr Phe Leu Pro Ser Val Glu Asp Tyr Tyr Asp Cys Glu Val Asp His 
             180                185                190
Trp Gly Leu Glu Glu Pro Leu Arg Lys His Trp Glu Phe Glu Glu Lys 
         195                200                205
Thr Leu Leu Pro Glu Thr Lys Glu Asn Val Leu Cys Val Leu Gly Leu 
     210                215                220
Phe Val Gly Leu Val Gly Ile Val Val Gly Ile Val Leu Ile Ile Lys 
 225                230                235                240
Gly Leu Arg Lys Arg Asn Ala Val Glu Gly Arg Gln Gly Ala Leu 
                 245                250                255



<210> 3338
<211> 1237
<212> DNA
<213> Homo sapiens
<308> NM_019111
<400> 3338

attcttgtc  gttctgcct  actcccgag  tctactgac  cccaaaaga  cgcccaaga  60
gaaaatggc  ataagtgga  tccctgtgc  aggattttt  atcatagct  tgctgatga  120
cgctcagga  tcatgggct  tcaaagaag  acatgtgat  atccaggcc  agttctatc  180
gaatcctga  caatcaggc  agtttatgt  tgactttga  ggtgatgag  ttttccatg  240
ggatatggc  aagaaggag  cggtctggc  gcttgaaga  tttggacga  ttgccagct  300
tgaggctca  ggtgcattg  ccaacatag  tgtggacaa  gccaacctg  aaatcatga  360
aaagcgctc  aactatact  cgatcacca  tgtacctcc  gaggtaact  tgctcacga  420
cagccctgt  gaactgaga  agcccaacg  cctcatctg  ttcatcgac  agttcaccc  480
accagtggt  aatgtcacg  ggcttcgaa  tggaaaacc  gtcaccaca  gagtgtcag  540
gacagtctt  ctgcccagg  aagaccacc  tttccgcaa  ttccactat  tccccttcc  600
gccctcaac  gaggacgtt  acgactgca  ggtggagca  tggggcttg  atgagcctc  660
tctcaagca  tgggagttt  atgctccaa  ccctctccc  gagactaca  agaacgtgg  720
gtgtgccct  ggcctgact  tgggtctgg  gggcatcat  attgggacc  tcttcatca  780
caagggagt  cgcaaaagc  atgcagcag  acgcagggg  cctctgtaa  gcacatgga  840
gtgatgatg  ttcttagag  gaagatcac  gaagaaact  ctgctttaa  gactttaca  900
agctggcaa  attacaatc  ttgacctca  tgaaagcag  catcttcag  gttttccag  960
cctatagcc  ccccaagtg  ggttatgcc  cctcgattg  tccgtactc  aacatctag  1020
tggctttcc  tgtctattg  cttttcctg  atctatttt  ctctatttc  tatcatttt  1080
ttatcacca  gcaatgcct  tggaataaa  catacagga  tctgtctct  ctatggaat  1140
ccccatggg  ctctcttgt  tacttattg  ttaaggttt  ctcaaactg  gatttttct  1200
aacacaata  actattttg  tgatcttgg  tggaaaa  1237



<210> 3339
<211> 254
<212> PRT
<213> Homo sapiens
<308> P01903
<400> 3339

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
  1               5                  10                  15
Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
             20                  25                  30
Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
         35                  40                  45
Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
     50                  55                  60
Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
 65                  70                  75                  80
Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                 85                  90                  95
Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
             100                105                110
Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
         115                120                125
Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
     130                135                140
Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
 145                150                155                160
Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                 165                170                175
Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
             180                185                190
Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
         195                200                205
Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
     210                215                220
Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
 225                230                235                240
Gly Val Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                 245                250



<210> 3340
<211> 805
<212> DNA
<213> Rattus norvegicus
<308> M15562
<400> 3340

gtgattcca  aggtgactg  actccccaa  agcccggtg  acctgggag  gcccaacat  60
ctcatctgt  tcattgaca  gttctcccc  ccagcggtc  atgtcacct  gcttcggaa  120
ggacagcct  tcaccaaag  cgtgtcaga  acagtgttt  tcccaaggg  ggaccacct  180
ttccgcaaa  tccactatc  caccttcct  ccctccgtg  aagattact  tgactgtga  240
gtggatcac  ggggtctgg  ggagcctct  cggaagcac  gggagtttg  agagaaaac  300
ctcctccca  aaactaaag  gaatgtcct  tgtgttctc  ggttgtttg  gggtctggt  360
ggcatcgtc  tcgggattg  gctcatcat  aagggcctt  ggaaacgca  cgcagtgga  420
cgccaagga  ccctgtgag  taccgggag  tgatggctt  cgtgagagc  catagaaga  480
atgtgctgt  acagcatct  aggctaccc  ttctctcag  tcttcacct  agcagagac  540
tcttctgca  tttccaacc  caagcctcg  gccagattc  ctggtctaa  gtctggctg  600
ggttctccg  ctgcttcct  tatctatat  ctattttcc  tcatttata  taattcctc  660
gtggcacat  tcacagagc  cttcctccg  tgcggaact  tctaagaat  gaggcatct  720
ctgttcact  acggcttga  atttctcca  actgtgttt  ctctttctc  ttttcaata  780
ataataaac  ccttgggtc  tgaat  805



<210> 3341
<211> 145
<212> PRT
<213> Rattus norvegicus
<308> AAA41609
<400> 3341

Val Ile Pro Glu Val Thr Val Leu Pro Lys Ser Pro Val Asn Leu Gly 
  1               5                  10                  15
Glu Pro Asn Ile Leu Ile Cys Phe Ile Asp Lys Phe Ser Pro Pro Ala 
             20                  25                  30
Val Asn Val Thr Trp Leu Arg Asn Gly Gln Pro Val Thr Lys Gly Val 
         35                  40                  45
Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe 
     50                  55                  60
His Tyr Leu Thr Phe Leu Pro Ser Val Glu Asp Tyr Tyr Asp Cys Glu 
 65                  70                  75                  80
Val Asp His Trp Gly Leu Glu Glu Pro Leu Arg Lys His Trp Glu Phe 
                 85                  90                  95
Glu Glu Lys Thr Leu Leu Pro Glu Thr Lys Glu Asn Val Leu Cys Val 
             100                105                110
Leu Gly Leu Phe Val Gly Leu Val Gly Ile Val Val Gly Ile Val Leu 
         115                120                125
Ile Ile Lys Gly Leu Arg Lys Arg Asn Ala Val Glu Arg Gln Gly Ala 
     130                135                140
Leu 
 145



<210> 3342
<211> 819
<212> DNA
<213> Homo sapiens
<308> M60334
<400> 3342

actcccaaa  gagcgccca  gaagaaaat  gccataagt  gagtccctg  gctaggatt  60
ttcatcata  ctgtgctga  gagcgctca  gaatcatgg  ctatcaaag  agaacatgt  120
atcatccag  ccgagttct  tctgaatcc  gaccaatca  gcgagttta  gtttgactt  180
gatggtgat  agattttcc  tgtggatat  gcaaagaag  agacggtct  gcggcttga  240
gaatttgga  gatttgcca  ctttgaggc  caaggtgca  tggccaaca  agctgtgga  300
aaagccaac  tggaaatca  gacaaagcg  tccaactat  ctccgatca  caatgtacc  360
ccagaggta  ctgtgctca  gaacagccc  gtggaactg  gagagccca  cgtcctcat  420
tgtttcata  acaagttca  cccaccagt  gtcaatgtc  cgtggcttc  aaatggaaa  480
cctgtcacc  caggagtgt  agagacagt  ttcctgccc  gggaagacc  ccttttccg  540
aagttccac  atctcccct  cctgccctc  actgaggac  tttacgact  cagggtgga  600
cactggggc  tggatgagc  tcttctcaa  cactgggag  ttgatgctc  aagccctct  660
ccagagact  cagagaacg  ggtgtgtgc  ctgggcctg  ctgtgggtc  ggtgggcat  720
attattggg  ccatcttca  catcaaggg  ttgcgcaaa  gcaatgcag  agaacgcag  780
gggcctctg  aaggcacat  gaggtgatg  tgtttctta  819



<210> 3343
<211> 254
<212> PRT
<213> Homo sapiens
<308> P01903
<400> 3343

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
  1               5                  10                  15
Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
             20                  25                  30
Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
         35                  40                  45
Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
     50                  55                  60
Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
 65                  70                  75                  80
Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                 85                  90                  95
Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
             100                105                110
Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
         115                120                125
Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
     130                135                140
Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
 145                150                155                160
Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                 165                170                175
Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
             180                185                190
Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
         195                200                205
Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
     210                215                220
Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
 225                230                235                240
Gly Val Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                 245                250



<210> 3344
<211> 805
<212> DNA
<213> Rattus norvegicus
<308> M15562
<400> 3344

gtgattcca  aggtgactg  actccccaa  agcccggtg  acctgggag  gcccaacat  60
ctcatctgt  tcattgaca  gttctcccc  ccagcggtc  atgtcacct  gcttcggaa  120
ggacagcct  tcaccaaag  cgtgtcaga  acagtgttt  tcccaaggg  ggaccacct  180
ttccgcaaa  tccactatc  caccttcct  ccctccgtg  aagattact  tgactgtga  240
gtggatcac  ggggtctgg  ggagcctct  cggaagcac  gggagtttg  agagaaaac  300
ctcctccca  aaactaaag  gaatgtcct  tgtgttctc  ggttgtttg  gggtctggt  360
ggcatcgtc  tcgggattg  gctcatcat  aagggcctt  ggaaacgca  cgcagtgga  420
cgccaagga  ccctgtgag  taccgggag  tgatggctt  cgtgagagc  catagaaga  480
atgtgctgt  acagcatct  aggctaccc  ttctctcag  tcttcacct  agcagagac  540
tcttctgca  tttccaacc  caagcctcg  gccagattc  ctggtctaa  gtctggctg  600
ggttctccg  ctgcttcct  tatctatat  ctattttcc  tcatttata  taattcctc  660
gtggcacat  tcacagagc  cttcctccg  tgcggaact  tctaagaat  gaggcatct  720
ctgttcact  acggcttga  atttctcca  actgtgttt  ctctttctc  ttttcaata  780
ataataaac  ccttgggtc  tgaat  805



<210> 3345
<211> 255
<212> PRT
<213> Rattus norvegicus
<308> CAA68540
<400> 3345

Met Ala Thr Ile Gly Asp Leu Val Ile Arg Phe Phe Phe Met Ala Val 
  1               5                  10                  15
Leu Met Ser Pro Gln Lys Ser Trp Ala Ile Lys Glu Glu His Thr Ile 
             20                  25                  30
Ile Gln Ala Glu Phe Tyr Leu Ser Pro Asp Gln Asn Gly Glu Phe Met 
         35                  40                  45
Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Ile Lys Lys Ser 
     50                  55                  60
Glu Thr Ile Trp Arg Leu Glu Glu Phe Ala Lys Phe Ala Ser Phe Glu 
 65                  70                  75                  80
Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Asp 
                 85                  90                  95
Ile Met Ile Lys Arg Ser Asn Asn Thr Pro Asp Ala Asn Val Ile Pro 
             100                105                110
Glu Val Thr Val Leu Pro Lys Ser Pro Val Asn Leu Gly Glu Pro Asn 
         115                120                125
Ile Leu Ile Cys Phe Ile Asp Lys Phe Ser Pro Pro Ala Val Asn Val 
     130                135                140
Thr Trp Leu Arg Asn Gly Gln Pro Val Thr Lys Gly Val Ser Glu Thr 
 145                150                155                160
Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                 165                170                175
Thr Phe Leu Pro Ser Val Glu Asp Tyr Tyr Asp Cys Glu Val Asp His 
             180                185                190
Trp Gly Leu Glu Glu Pro Leu Arg Lys His Trp Glu Phe Glu Glu Lys 
         195                200                205
Thr Leu Leu Pro Glu Thr Lys Glu Asn Val Leu Cys Val Leu Gly Leu 
     210                215                220
Phe Val Gly Leu Val Gly Ile Val Val Gly Ile Val Leu Ile Ile Lys 
 225                230                235                240
Gly Leu Arg Lys Arg Asn Ala Val Glu Gly Arg Gln Gly Ala Leu 
                 245                250                255



<210> 3346
<211> 1237
<212> DNA
<213> Homo sapiens
<308> NM_019111
<400> 3346

attcttgtc  gttctgcct  actcccgag  tctactgac  cccaaaaga  cgcccaaga  60
gaaaatggc  ataagtgga  tccctgtgc  aggattttt  atcatagct  tgctgatga  120
cgctcagga  tcatgggct  tcaaagaag  acatgtgat  atccaggcc  agttctatc  180
gaatcctga  caatcaggc  agtttatgt  tgactttga  ggtgatgag  ttttccatg  240
ggatatggc  aagaaggag  cggtctggc  gcttgaaga  tttggacga  ttgccagct  300
tgaggctca  ggtgcattg  ccaacatag  tgtggacaa  gccaacctg  aaatcatga  360
aaagcgctc  aactatact  cgatcacca  tgtacctcc  gaggtaact  tgctcacga  420
cagccctgt  gaactgaga  agcccaacg  cctcatctg  ttcatcgac  agttcaccc  480
accagtggt  aatgtcacg  ggcttcgaa  tggaaaacc  gtcaccaca  gagtgtcag  540
gacagtctt  ctgcccagg  aagaccacc  tttccgcaa  ttccactat  tccccttcc  600
gccctcaac  gaggacgtt  acgactgca  ggtggagca  tggggcttg  atgagcctc  660
tctcaagca  tgggagttt  atgctccaa  ccctctccc  gagactaca  agaacgtgg  720
gtgtgccct  ggcctgact  tgggtctgg  gggcatcat  attgggacc  tcttcatca  780
caagggagt  cgcaaaagc  atgcagcag  acgcagggg  cctctgtaa  gcacatgga  840
gtgatgatg  ttcttagag  gaagatcac  gaagaaact  ctgctttaa  gactttaca  900
agctggcaa  attacaatc  ttgacctca  tgaaagcag  catcttcag  gttttccag  960
cctatagcc  ccccaagtg  ggttatgcc  cctcgattg  tccgtactc  aacatctag  1020
tggctttcc  tgtctattg  cttttcctg  atctatttt  ctctatttc  tatcatttt  1080
ttatcacca  gcaatgcct  tggaataaa  catacagga  tctgtctct  ctatggaat  1140
ccccatggg  ctctcttgt  tacttattg  ttaaggttt  ctcaaactg  gatttttct  1200
aacacaata  actattttg  tgatcttgg  tggaaaa  1237



<210> 3347
<211> 254
<212> PRT
<213> Homo sapiens
<308> P01903
<400> 3347

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
  1               5                  10                  15
Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
             20                  25                  30
Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
         35                  40                  45
Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
     50                  55                  60
Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
 65                  70                  75                  80
Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                 85                  90                  95
Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
             100                105                110
Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
         115                120                125
Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
     130                135                140
Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
 145                150                155                160
Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                 165                170                175
Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
             180                185                190
Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
         195                200                205
Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
     210                215                220
Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
 225                230                235                240
Gly Val Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                 245                250



<210> 3348
<211> 1749
<212> DNA
<213> Rattus norvegicus
<308> M15768
<400> 3348

agaagaaag  actggccag  gactcagat  cccatccgc  caagcaggc  accatgtgc  60
gaggcttct  tttcaggca  ttgctgccg  tgctgctcc  gcagctgtc  aaactccta  120
ttgtcaccc  aggaaagac  gtggtgctg  ggaaggaag  gggttcagc  gaactgccc  180
gtgaaagta  ctcgaggag  agtgcatcc  tcgcgtgga  gtcctctga  caaaagaca  240
ttctgggat  taagaacaa  ttattgatt  aaggttcac  tgagctgta  agtcgtttt  300
attccagaa  aaatgcatg  gagagagga  catttcccc  catcatcaa  aaacttagg  360
tggaggact  tcagactta  gtctgcgag  tggagaaca  gaaagagga  gtggagttg  420
gggtcttca  agtgacctt  aatccgggt  ccagactgt  gcaggggca  agcctgacc  480
tgatcttgg  tagcaaccc  aaggtctct  accccccga  agagtgcaa  cacaaaagc  540
gtaacattg  caaggactc  aaagctttc  ccacgcaca  cctaaggat  caggacagt  600
gcatctgga  ctgcaccgt  accctgaac  agaagaagc  ctcatttga  atgaaactc  660
cagtgctgg  ctttgcgag  acatccatc  cggcctata  gagtgaggg  gagtcagcg  720
agttctcct  cccactcaa  cttggagag  aaagcctgc  gggagagtt  agatggaag  780
cagagaagg  tccttcttc  cagtcctgg  tcaccttct  cctaaagaa  caaaaggtg  840
ctgtgcaga  gtctactag  aaccccaag  tccagctgt  cgaaacgct  ccactcacc  900
ttcagatac  ccaggtctc  cttcagttt  ctggttctg  caacctgac  ctgactctg  960
acagaggga  actgtatca  gaagtgaac  tggtggtga  gaaagtgac  cagcccgac  1020
gcaacactt  gacctgtga  gtgatggga  ccacctcac  caagatgag  ctgatcttg  1080
agcaggaga  tcaggaggc  agggtctcc  ggcaggaga  agtgattca  gtgcaggcc  1140
ctgaagcag  ggtgtggca  tgtctactg  gtgaaggtg  agaggtcaa  atggactcc  1200
agatccagg  tttatccaa  gggttgaac  agacaatgt  cctggctgt  gtgctgggg  1260
gcgccttca  ctttctggt  ttcacgggg  tctgcatcc  attctgtgt  aggtgccgg  1320
accaacagc  ccaggcagc  cggatgtct  agatcaaga  gcttctcag  gagaagaag  1380
cttgccagt  ctcccaccg  atgcagaaa  gccacaatc  catatgagg  ctgggcccc  1440
cctgcagcc  tgcctgtgt  ctgtcgctg  cccaggcct  tggaccaga  gaatgtagc  1500
cacacagtg  ctctggcct  ctgcttttc  cttccacaa  tggccacgg  ttctctgcc  1560
ctgttccca  gcccgttgg  tgagcttgc  ctcggctgt  tttcagaca  tcaagcaca  1620
ccagccagc  tattgatcc  ccgtagctg  ctttacgcc  gagcccagc  cttctctga  1680
taacatcct  gatcttctt  ccagctgtc  gcttggatc  aagggcacc  gacctggat  1740
gtgggactg  1749



<210> 3349
<211> 457
<212> PRT
<213> Rattus norvegicus
<308> P05540
<400> 3349

Met Cys Arg Gly Phe Ser Phe Arg His Leu Leu Pro Leu Leu Leu Leu 
  1               5                  10                  15
Gln Leu Ser Lys Leu Leu Val Val Thr Gln Gly Lys Thr Val Val Leu 
             20                  25                  30
Gly Lys Glu Gly Gly Ser Ala Glu Leu Pro Cys Glu Ser Thr Ser Arg 
         35                  40                  45
Arg Ser Ala Ser Phe Ala Trp Lys Ser Ser Asp Gln Lys Thr Ile Leu 
     50                  55                  60
Gly Tyr Lys Asn Lys Leu Leu Ile Lys Gly Ser Leu Glu Leu Tyr Ser 
 65                  70                  75                  80
Arg Phe Asp Ser Arg Lys Asn Ala Trp Glu Arg Gly Ser Phe Pro Leu 
                 85                  90                  95
Ile Ile Asn Lys Leu Arg Met Glu Asp Ser Gln Thr Tyr Val Cys Glu 
             100                105                110
Leu Glu Asn Lys Lys Glu Glu Val Glu Leu Trp Val Phe Arg Val Thr 
         115                120                125
Phe Asn Pro Gly Thr Arg Leu Leu Gln Gly Gln Ser Leu Thr Leu Ile 
     130                135                140
Leu Asp Ser Asn Pro Lys Val Ser Asp Pro Pro Ile Glu Cys Lys His 
 145                150                155                160
Lys Ser Ser Asn Ile Val Lys Asp Ser Lys Ala Phe Ser Thr His Ser 
                 165                170                175
Leu Arg Ile Gln Asp Ser Gly Ile Trp Asn Cys Thr Val Thr Leu Asn 
             180                185                190
Gln Lys Lys His Ser Phe Asp Met Lys Leu Ser Val Leu Gly Phe Ala 
         195                200                205
Ser Thr Ser Ile Thr Ala Tyr Lys Ser Glu Gly Glu Ser Ala Glu Phe 
     210                215                220
Ser Phe Pro Leu Asn Leu Gly Glu Glu Ser Leu Gln Gly Glu Leu Arg 
 225                230                235                240
Trp Lys Ala Glu Lys Ala Pro Ser Ser Gln Ser Trp Ile Thr Phe Ser 
                 245                250                255
Leu Lys Asn Gln Lys Val Ser Val Gln Lys Ser Thr Ser Asn Pro Lys 
             260                265                270
Phe Gln Leu Ser Glu Thr Leu Pro Leu Thr Leu Gln Ile Pro Gln Val 
         275                280                285
Ser Leu Gln Phe Ala Gly Ser Gly Asn Leu Thr Leu Thr Leu Asp Arg 
     290                295                300
Gly Ile Leu Tyr Gln Glu Val Asn Leu Val Val Met Lys Val Thr Gln 
 305                310                315                320
Pro Asp Ser Asn Thr Leu Thr Cys Glu Val Met Gly Pro Thr Ser Pro 
                 325                330                335
Lys Met Arg Leu Ile Leu Lys Gln Glu Asn Gln Glu Ala Arg Val Ser 
             340                345                350
Arg Gln Glu Lys Val Ile Gln Val Gln Ala Pro Glu Ala Gly Val Trp 
         355                360                365
Gln Cys Leu Leu Ser Glu Gly Glu Glu Val Lys Met Asp Ser Lys Ile 
     370                375                380
Gln Val Leu Ser Lys Gly Leu Asn Gln Thr Met Phe Leu Ala Val Val 
 385                390                395                400
Leu Gly Ser Ala Phe Ser Phe Leu Val Phe Thr Gly Leu Cys Ile Leu 
                 405                410                415
Phe Cys Val Arg Cys Arg His Gln Gln Arg Gln Ala Ala Arg Met Ser 
             420                425                430
Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Ser His 
         435                440                445
Arg Met Gln Lys Ser His Asn Leu Ile 
     450                455



<210> 3350
<211> 3084
<212> DNA
<213> Homo sapiens
<308> NM_000616
<400> 3350

ctgggctcc  ggttgcaga  ctccaagtc  tcacacaga  acgcctgtt  gagaagcag  60
gggcaagaa  gacgcaagc  cagaggccc  gccatttct  tgggctcag  tccctactg  120
ctcaggccc  tgcctccct  ggcaaggcc  caatgaacc  gggagtccc  tttaggcac  180
tgcttctgg  gctgcaact  gcgctcctc  cagcagcca  tcagggaaa  aaagtggtg  240
tgggcaaaa  aggggatac  gtggaactg  cctgtacag  ttcccagaa  aagagcata  300
aattccact  gaaaaactc  aaccagata  agattctgg  aaatcaggg  tccttctta  360
ctaaaggtc  atccaagct  aatgatcgc  ctgactcaa  aagaagcct  tgggaccaa  420
gaaactttc  cctgatcat  aagaatctt  agatagaag  ctcagatac  tacatctgt  480
aagtggagg  ccagaagga  gaggtgcaa  tgctagtgt  cggattgac  gccaactct  540
acacccacc  gcttcaggg  cagagcctg  ccctgacct  ggagagccc  cctggtagt  600
gcccctcag  gcaatgtag  agtccaagg  gtaaaaaca  acagggggg  aagaccctc  660
ccgtgtctc  gctggagct  caggatagt  gcacctgga  atgcactgt  ttgcagaac  720
agaagaagg  ggagttcaa  atagacatc  tggtgctag  tttccagaa  gcctccagc  780
tagtctata  gaaagaggg  gaacaggtg  agttctcct  cccactcgc  tttacagtt  840
aaaagctga  gggcagtgg  gagctgtgg  ggcaggcgg  gagggcttc  tcctccaag  900
cttggatca  ctttgacct  aagaacaag  aagtgtctg  aaaacgggt  acccaggac  960
ctaagctcc  gatgggcaa  aagctcccg  tccacctca  cctgcccca  gccttgcct  1020
agtatgctg  ctctggaaa  ctcaccctg  cccttgaag  gaaaacagg  aagttgcat  1080
aggaagtga  cctggtggt  atgagagcc  ctcagctcc  gaaaaattt  acctgtgag  1140
tgtggggac  cacctcccc  aagctgatg  tgagcttga  actggagaa  aaggaggca  1200
aggtctcga  gcgggagaa  gcggtgtgg  tgctgaacc  tgaggcggg  atgtggcag  1260
gtctgctga  tgactcggg  caggtcctg  tggaatcca  catcaaggt  ctgcccaca  1320
ggtccaccc  ggtgcagcc  atggccctg  ttgtgctgg  gggcgtcgc  ggcctcctg  1380
ttttcattg  gctaggcat  ttcttctgt  tcaggtgcc  gcaccgaag  cgccaagca  1440
agcggatgt  tcagatcaa  agactcctc  gtgagaaga  gacctgcca  tgccctcac  1500
ggtttcaga  gacatgtag  cccatttga  gcacgaggc  aggcagatc  cacttgcag  1560
ctccccagg  gtctgcccc  cgtttcctg  ctgcggacc  gatgaatgt  gcagatccc  1620
ggcctctgg  ctcctgttc  cctcctcta  aatttgcca  tgtttctcc  gggttaggc  1680
ccggcttca  tggttgagt  ttgctctct  gtttccaga  gcttaatca  accgtcctc  1740
acgccattt  cttttcctt  aagcctagc  cttctctca  tatttctct  tgaccctct  1800
cccactgct  atttggatc  caggggagt  ttcagggcc  gccctggct  gcatggagg  1860
tgaggctgg  tgtctggaa  catggagca  gggactgtt  ttttacaag  caggaccct  1920
ggaccacag  gggcaggag  ttgcacgaa  tcacacagc  aagccagtc  aggatggat  1980
cagatccag  ggtttctgg  agccagtac  tcctgcccc  tgctgcccg  ttctcaccc  2040
atgtgggtg  ggccacaga  tcacatcct  accttgcac  aacagcccc  ctggacaca  2100
ccccatgta  acggcctca  gggatgtct  acatcctct  tctatttga  acttagaaa  2160
atcctacaa  gctggcagt  acagaacta  gatgatcat  tccagttta  agaccagaa  2220
cagagctca  agaggctag  tgattgatt  ccaagtgcc  gactagcaa  tgctggagt  2280
gggactaac  caggtccct  gtcccaagt  ccactgctg  ctcttgaat  cagggacaa  2340
tgccacacg  ctctcacca  tggctagtg  tgggtactc  atgtgtact  ttgggttca  2400
agaagcaca  cacccatgg  aagggtcca  ctcagagaa  ttacgagca  ggatgaagg  2460
ctccctgtc  aaaatccct  cttcatccc  cgctggtgg  agaatctgt  accagagga  2520
aaagccttt  gctcttcta  tcagagtgc  agctgggag  acaggcact  caggagaga  2580
tgcccagtg  ccagtcact  accctgtgc  gaacctcct  gaagcgagc  ttgctggga  2640
agggggtag  tagcctgag  gggaaccct  caagggacc  caaaggtga  tgtgccagg  2700
tctgcgcct  ccccacacc  tcccttacc  tcctccaga  cattcagga  acagggaaa  2760
cagggttac  aatcttctt  atccacttc  ctcaggatc  cctctcttc  tacccttcc  2820
caccacttc  ctcagtccc  actcctttt  cctatttcc  tctcctcct  tctttaaag  2880
ctgcctctt  caggaagac  cccctattg  tgctggggc  ccccatttg  ttactttgc  2940
tttgtgccc  ctctccacc  ctgctcccc  gagctgaaa  aaaaataca  taaacttac  3000
ataaagata  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  3060
aaaaaaaaa  aaaaaaaaa  aaaa  3084



<210> 3351
<211> 458
<212> PRT
<213> Homo sapiens
<308> P01730
<400> 3351

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
  1               5                  10                  15
Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
             20                  25                  30
Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
         35                  40                  45
Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
     50                  55                  60
Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
 65                  70                  75                  80
Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                 85                  90                  95
Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
             100                105                110
Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
         115                120                125
Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
     130                135                140
Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
 145                150                155                160
Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                 165                170                175
Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
             180                185                190
Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
         195                200                205
Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
     210                215                220
Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
 225                230                235                240
Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                 245                250                255
Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
             260                265                270
Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
         275                280                285
Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
     290                295                300
Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
 305                310                315                320
Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                 325                330                335
Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
             340                345                350
Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
         355                360                365
Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
     370                375                380
Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
 385                390                395                400
Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                 405                410                415
Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
             420                425                430
Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
         435                440                445
His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
     450                455



<210> 3352
<211> 1124
<212> DNA
<213> Rattus norvegicus
<308> M15882
<400> 3352

tctccgctc  tcctccggt  gcagccgcc  gcacagtgt  cgctgctgg  cggggtgtc  60
gcggatcgg  cggttggtt  cggcttcgg  gtcgctgcg  ttgagttgg  ccgtcatgg  120
tgagttgga  ccatttggc  ctcccgccg  tgcgcccgg  ggccccgcg  tcgggaacg  180
ggtggcggg  gccggcgag  aagacccgg  cgcggcctt  ttggcgcag  aggagagtg  240
gattgcggg  atagagaac  acgaggcct  cgccatcct  gacggcggc  cccccgggc  300
gcaggcaca  ggcgagccg  cggggggtc  tgatgcggt  gatggagtg  tgaatggcg  360
atactacca  gagagcaat  gtccaacag  cagttacgc  gccatttca  aagtggatc  420
gttgcagtc  gagcctgaa  gtatccgta  gtggagaga  gagcagaca  agcgcctgg  480
agccctcga  gccaattct  ggaagcagg  agcagagtg  aaagaaaag  cagtgaagg  540
gctggaaga  tggtacgca  ggcaggatg  gcagctaca  aagacaaaa  ccagcaaca  600
ggtggcaga  gaagctttc  acaaacaac  cttcgctga  gtgattggt  atgtcacaa  660
cataaacca  ccttgctac  gcctagaac  ggcagcaga  gaagccttt  taaacgaca  720
tgacgagtc  tccccaggc  ctgagtggg  gcgggtggc  cgcctgtgt  actttaacc  780
caagtccag  aaacaggcc  aagatgtct  tcgcatgcg  tcagtcctc  tctccctga  840
gcaggcgcc  ctggtgcat  gaagagcca  cctgtggaa  cactacgtc  ccgatctta  900
tcctactca  tgaagctgt  cacgcaatt  gattaatta  gccgagttc  tttggacca  960
accttttgt  tttagagtt  atcattgtt  gtgattgca  gtttccttc  actgtgttc  1020
ccctggcat  cagagaaga  agaggaaga  gaagggagg  gagctccca  cagtagcct  1080
aacctgtgc  tttgtgcat  attctgaga  taaatttct  tttc  1124



<210> 3353
<211> 248
<212> PRT
<213> Rattus norvegicus
<308> P08081
<400> 3353

Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
  1               5                  10                  15
Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
             20                  25                  30
Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
         35                  40                  45
Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Ala 
     50                  55                  60
His Gly Glu Pro Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn 
 65                  70                  75                  80
Gly Glu Tyr Tyr Gln Glu Ser Asn Gly Pro Thr Asp Ser Tyr Ala Ala 
                 85                  90                  95
Ile Ser Glu Val Asp Arg Leu Gln Ser Glu Pro Glu Ser Ile Arg Lys 
             100                105                110
Trp Arg Glu Glu Gln Thr Glu Arg Leu Glu Ala Leu Asp Ala Asn Ser 
         115                120                125
Arg Lys Gln Glu Ala Glu Trp Lys Glu Lys Ala Val Lys Glu Leu Glu 
     130                135                140
Glu Trp Tyr Ala Arg Gln Asp Glu Gln Leu Gln Lys Thr Lys Ala Ser 
 145                150                155                160
Asn Arg Val Ala Asp Glu Ala Phe Tyr Lys Gln Pro Phe Ala Asp Val 
                 165                170                175
Ile Gly Tyr Val Thr Asn Ile Asn His Pro Cys Tyr Ser Leu Glu Gln 
             180                185                190
Ala Ala Glu Glu Ala Phe Val Asn Asp Ile Asp Glu Ser Ser Pro Gly 
         195                200                205
Thr Glu Trp Glu Arg Val Ala Arg Leu Cys Asp Phe Asn Pro Lys Ser 
     210                215                220
Ser Lys Gln Ala Lys Asp Val Ser Arg Met Arg Ser Val Leu Ile Ser 
 225                230                235                240
Leu Lys Gln Ala Pro Leu Val His 
                 245



<210> 3354
<211> 1105
<212> DNA
<213> Homo sapiens
<308> M20471
<400> 3354

gccaccgct  tggtgtcgg  gggtcggtt  gtttttgtc  caccgttgg  gtccgtgcc  60
ttcagttgc  cgccatggc  gagctggat  cgttcggcg  ccctgccgg  gcccctggc  120
gtcccgcgc  ggggaacgg  gtggccggc  ccggcgaag  agacccggc  gcggccttc  180
tggcgcagc  agagagcga  attgcgggc  tcgagaacg  cgaggcctt  gccatcctg  240
acggcggcg  ccccgggcc  cagccgcac  gcgagccgc  ggggggtcc  gatgctgtt  300
atggagtaa  gaatggtga  tactaccag  aaagtaatg  tccaacaga  agttatgca  360
ctatttcac  agtggatcg  ttgcagtca  agcctgaaa  tatccgtaa  tggagagaa  420
aacaaatgg  acgcttgga  gcccttgat  ccaattctc  gaagcaaga  gcagagtgg  480
aagaaaagg  aataaagga  ctagaagaa  ggtatgcaa  acaggacga  cagctacag  540
aaacaaaag  aaacaacag  gtggcagat  aagctttct  caaacaacc  ttcgctgac  600
tgattggtt  tgtcacaaa  ataaaccat  cttgctaca  cctagaaca  gcagcagaa  660
aagcctttg  aaatgacat  gacgagtcg  ccccaggca  tgagtggga  cgggtggcc  720
ggctgtgtg  ctttaaccc  aagtctagc  agcaggcca  agatgtctc  cgcatgcgc  780
cagtcctca  ctccctcaa  caggccccg  tggtgcact  aagagccac  ctgtggaaa  840
actacatct  caatatctt  atcctactc  gtgaagctc  tcacagtca  tggattaat  900
atgttgagt  cttttggac  aaacctttt  gtctttaga  ttgttcatt  tttgtgatt  960
catgtttcc  tccttcaac  gtgttctcc  tggcattca  agaggaggg  gaggaggaa  1020
aggaagggg  gggaagctt  ccaagagta  cctcaacct  tgcttctgt  cattattct  1080
agaataaat  tctgtttca  actgt  1105



<210> 3355
<211> 248
<212> PRT
<213> Homo sapiens
<308> P09496
<400> 3355

Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
  1               5                  10                  15
Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
             20                  25                  30
Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
         35                  40                  45
Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro 
     50                  55                  60
His Gly Glu Pro Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn 
 65                  70                  75                  80
Gly Glu Tyr Tyr Gln Glu Ser Asn Gly Pro Thr Asp Ser Tyr Ala Ala 
                 85                  90                  95
Ile Ser Gln Val Asp Arg Leu Gln Ser Glu Pro Glu Ser Ile Arg Lys 
             100                105                110
Trp Arg Glu Glu Gln Met Glu Arg Leu Glu Ala Leu Asp Ala Asn Ser 
         115                120                125
Arg Lys Gln Glu Ala Glu Trp Lys Glu Lys Ala Ile Lys Glu Leu Glu 
     130                135                140
Glu Trp Tyr Ala Arg Gln Asp Glu Gln Leu Gln Lys Thr Lys Ala Asn 
 145                150                155                160
Asn Arg Val Ala Asp Glu Ala Phe Tyr Lys Gln Pro Phe Ala Asp Val 
                 165                170                175
Ile Gly Tyr Val Thr Asn Ile Asn His Pro Cys Tyr Ser Leu Glu Gln 
             180                185                190
Ala Ala Glu Glu Ala Phe Val Asn Asp Ile Asp Glu Ser Ser Pro Gly 
         195                200                205
Thr Glu Trp Glu Arg Val Ala Arg Leu Cys Asp Phe Asn Pro Lys Ser 
     210                215                220
Ser Lys Gln Ala Lys Asp Val Ser Arg Met Arg Ser Val Leu Ile Ser 
 225                230                235                240
Leu Lys Gln Ala Pro Leu Val His 
                 245



<210> 3356
<211> 1124
<212> DNA
<213> Rattus norvegicus
<308> M15882
<400> 3356

tctccgctc  tcctccggt  gcagccgcc  gcacagtgt  cgctgctgg  cggggtgtc  60
gcggatcgg  cggttggtt  cggcttcgg  gtcgctgcg  ttgagttgg  ccgtcatgg  120
tgagttgga  ccatttggc  ctcccgccg  tgcgcccgg  ggccccgcg  tcgggaacg  180
ggtggcggg  gccggcgag  aagacccgg  cgcggcctt  ttggcgcag  aggagagtg  240
gattgcggg  atagagaac  acgaggcct  cgccatcct  gacggcggc  cccccgggc  300
gcaggcaca  ggcgagccg  cggggggtc  tgatgcggt  gatggagtg  tgaatggcg  360
atactacca  gagagcaat  gtccaacag  cagttacgc  gccatttca  aagtggatc  420
gttgcagtc  gagcctgaa  gtatccgta  gtggagaga  gagcagaca  agcgcctgg  480
agccctcga  gccaattct  ggaagcagg  agcagagtg  aaagaaaag  cagtgaagg  540
gctggaaga  tggtacgca  ggcaggatg  gcagctaca  aagacaaaa  ccagcaaca  600
ggtggcaga  gaagctttc  acaaacaac  cttcgctga  gtgattggt  atgtcacaa  660
cataaacca  ccttgctac  gcctagaac  ggcagcaga  gaagccttt  taaacgaca  720
tgacgagtc  tccccaggc  ctgagtggg  gcgggtggc  cgcctgtgt  actttaacc  780
caagtccag  aaacaggcc  aagatgtct  tcgcatgcg  tcagtcctc  tctccctga  840
gcaggcgcc  ctggtgcat  gaagagcca  cctgtggaa  cactacgtc  ccgatctta  900
tcctactca  tgaagctgt  cacgcaatt  gattaatta  gccgagttc  tttggacca  960
accttttgt  tttagagtt  atcattgtt  gtgattgca  gtttccttc  actgtgttc  1020
ccctggcat  cagagaaga  agaggaaga  gaagggagg  gagctccca  cagtagcct  1080
aacctgtgc  tttgtgcat  attctgaga  taaatttct  tttc  1124



<210> 3357
<211> 248
<212> PRT
<213> Rattus norvegicus
<308> P08081
<400> 3357

Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
  1               5                  10                  15
Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
             20                  25                  30
Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
         35                  40                  45
Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Ala 
     50                  55                  60
His Gly Glu Pro Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn 
 65                  70                  75                  80
Gly Glu Tyr Tyr Gln Glu Ser Asn Gly Pro Thr Asp Ser Tyr Ala Ala 
                 85                  90                  95
Ile Ser Glu Val Asp Arg Leu Gln Ser Glu Pro Glu Ser Ile Arg Lys 
             100                105                110
Trp Arg Glu Glu Gln Thr Glu Arg Leu Glu Ala Leu Asp Ala Asn Ser 
         115                120                125
Arg Lys Gln Glu Ala Glu Trp Lys Glu Lys Ala Val Lys Glu Leu Glu 
     130                135                140
Glu Trp Tyr Ala Arg Gln Asp Glu Gln Leu Gln Lys Thr Lys Ala Ser 
 145                150                155                160
Asn Arg Val Ala Asp Glu Ala Phe Tyr Lys Gln Pro Phe Ala Asp Val 
                 165                170                175
Ile Gly Tyr Val Thr Asn Ile Asn His Pro Cys Tyr Ser Leu Glu Gln 
             180                185                190
Ala Ala Glu Glu Ala Phe Val Asn Asp Ile Asp Glu Ser Ser Pro Gly 
         195                200                205
Thr Glu Trp Glu Arg Val Ala Arg Leu Cys Asp Phe Asn Pro Lys Ser 
     210                215                220
Ser Lys Gln Ala Lys Asp Val Ser Arg Met Arg Ser Val Leu Ile Ser 
 225                230                235                240
Leu Lys Gln Ala Pro Leu Val His 
                 245



<210> 3358
<211> 1105
<212> DNA
<213> Homo sapiens
<308> M20471
<400> 3358

gccaccgct  tggtgtcgg  gggtcggtt  gtttttgtc  caccgttgg  gtccgtgcc  60
ttcagttgc  cgccatggc  gagctggat  cgttcggcg  ccctgccgg  gcccctggc  120
gtcccgcgc  ggggaacgg  gtggccggc  ccggcgaag  agacccggc  gcggccttc  180
tggcgcagc  agagagcga  attgcgggc  tcgagaacg  cgaggcctt  gccatcctg  240
acggcggcg  ccccgggcc  cagccgcac  gcgagccgc  ggggggtcc  gatgctgtt  300
atggagtaa  gaatggtga  tactaccag  aaagtaatg  tccaacaga  agttatgca  360
ctatttcac  agtggatcg  ttgcagtca  agcctgaaa  tatccgtaa  tggagagaa  420
aacaaatgg  acgcttgga  gcccttgat  ccaattctc  gaagcaaga  gcagagtgg  480
aagaaaagg  aataaagga  ctagaagaa  ggtatgcaa  acaggacga  cagctacag  540
aaacaaaag  aaacaacag  gtggcagat  aagctttct  caaacaacc  ttcgctgac  600
tgattggtt  tgtcacaaa  ataaaccat  cttgctaca  cctagaaca  gcagcagaa  660
aagcctttg  aaatgacat  gacgagtcg  ccccaggca  tgagtggga  cgggtggcc  720
ggctgtgtg  ctttaaccc  aagtctagc  agcaggcca  agatgtctc  cgcatgcgc  780
cagtcctca  ctccctcaa  caggccccg  tggtgcact  aagagccac  ctgtggaaa  840
actacatct  caatatctt  atcctactc  gtgaagctc  tcacagtca  tggattaat  900
atgttgagt  cttttggac  aaacctttt  gtctttaga  ttgttcatt  tttgtgatt  960
catgtttcc  tccttcaac  gtgttctcc  tggcattca  agaggaggg  gaggaggaa  1020
aggaagggg  gggaagctt  ccaagagta  cctcaacct  tgcttctgt  cattattct  1080
agaataaat  tctgtttca  actgt  1105



<210> 3359
<211> 248
<212> PRT
<213> Homo sapiens
<308> P09496
<400> 3359

Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
  1               5                  10                  15
Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
             20                  25                  30
Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
         35                  40                  45
Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro 
     50                  55                  60
His Gly Glu Pro Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn 
 65                  70                  75                  80
Gly Glu Tyr Tyr Gln Glu Ser Asn Gly Pro Thr Asp Ser Tyr Ala Ala 
                 85                  90                  95
Ile Ser Gln Val Asp Arg Leu Gln Ser Glu Pro Glu Ser Ile Arg Lys 
             100                105                110
Trp Arg Glu Glu Gln Met Glu Arg Leu Glu Ala Leu Asp Ala Asn Ser 
         115                120                125
Arg Lys Gln Glu Ala Glu Trp Lys Glu Lys Ala Ile Lys Glu Leu Glu 
     130                135                140
Glu Trp Tyr Ala Arg Gln Asp Glu Gln Leu Gln Lys Thr Lys Ala Asn 
 145                150                155                160
Asn Arg Val Ala Asp Glu Ala Phe Tyr Lys Gln Pro Phe Ala Asp Val 
                 165                170                175
Ile Gly Tyr Val Thr Asn Ile Asn His Pro Cys Tyr Ser Leu Glu Gln 
             180                185                190
Ala Ala Glu Glu Ala Phe Val Asn Asp Ile Asp Glu Ser Ser Pro Gly 
         195                200                205
Thr Glu Trp Glu Arg Val Ala Arg Leu Cys Asp Phe Asn Pro Lys Ser 
     210                215                220
Ser Lys Gln Ala Lys Asp Val Ser Arg Met Arg Ser Val Leu Ile Ser 
 225                230                235                240
Leu Lys Gln Ala Pro Leu Val His 
                 245



<210> 3360
<211> 3243
<212> DNA
<213> Rattus norvegicus
<308> M15944
<400> 3360

gcggagatg  gcaagtggc  aagctggac  gagtgcagg  gcaagctgc  gagcggctg  60
ggcgaggga  tttaggtga  gggaagatc  gaaagtcag  tggatatta  tgatatcaa  120
gctccaaag  cgaagaaga  acagcgatg  actccactg  agatcagcc  ttctgtgct  180
gtcttgctc  tgactatca  agctgtgac  atgattgct  tctatgcaa  ctatgatga  240
ggtatttgc  aatcatcag  ctgcataaa  tcagctgct  gactgatcc  gaacatgga  300
gcctctgct  agccatgta  ggacttctt  aaatatgct  gtggaggct  gttgaaacg  360
aatgtcatc  ctgagacca  ttcccgata  agtaatttt  acattctaa  agatgaact  420
gaagtcatt  tgaaagatg  ccttcaaga  cccaaaact  aggacatag  agcagtgca  480
aaagcaaaa  ctttgtaca  atcatgtat  aatgaatct  ctattgata  cagaggtgg  540
caacctctg  tcacactgt  accagatat  tatgggtgg  cagtagcat  acaaaactg  600
gaacaaaca  atggtactt  ttggacagc  gagaaatct  ttgcacaac  gaattctaa  660
tatgggaaa  aggtcctca  taatttttt  gttggcact  atgataaga  ttctaccca  720
catataatt  attttgacc  gcctcgact  ggcctccct  ccagagact  ctatgagtg  780
acaggaata  ataaagagg  ttgcacagc  tatgtggat  ttatgattt  tgtggccag  840
ctgattcgt  aggaacaaa  attgcctat  gatgaaaac  agctctctt  ggaaatgaa  900
aaagttatg  aattggaaa  agaaattgc  aatgccaca  ctaaaccag  agaccgaaa  960
gacccaatg  tgctttata  caaaatgac  ttggccaag  tccaaaata  cttctctct  1020
gagatcaat  ggaagccat  cagctggtc  aatttcaca  atgaaatca  gtcaactgt  1080
aatattaat  ttcaaaatg  ggaagaagt  gttgtttat  ctccagaat  tttaaccaa  1140
cttaagcct  ttcttacca  atattctcc  agagatctt  aaaatttaa  gtcctggag  1200
ttcataatg  atcttgtaa  cagcctcag  cgaaactac  aggagtcca  aaatgcttt  1260
cgcaaggcc  tttacggga  tacatccga  actgcaacc  ggagacggt  tgccaacta  1320
gtcaatggg  acatggaga  tgctgtggg  aggctttat  tggaagcag  ttttgctgg  1380
gagagcaag  acgtggttg  agatttgat  gcacaaatc  gtgaagttt  tattcagac  1440
ttagatgac  tcacttgga  ggatgctga  acaaaaaag  aagctgaag  gaaggccct  1500
gcaattaaa  aaaggattg  ctatcctga  gacatcatc  ccaatgaga  taaactgaa  1560
aatgagtat  ttgagttga  ctacaagga  gaggaatac  ttgagaaca  aattcaaaa  1620
ttgaaattc  gccaaagca  gcagctaaa  aagctccga  aaaaggtgg  caaagatga  1680
tggataagt  gcgcggcgg  agtcaatgc  ttttattcc  caggcagaa  tcagatcgt  1740
ttccccgcc  gcattttgc  gcccccatt  tttagtgct  ggcagtcca  ctcattgaa  1800
tatgggggc  tcggcatgg  catcggaca  gaaatcaca  atggctttg  tgacaatgg  1860
agaaatttt  acaaagatg  agacctcgt  gactggtgg  ctcagcagt  tgcaaataa  1920
ttcaaagac  aatcccagt  tatggtgta  cagtatgga  actttacat  ggacctagc  1980
ggtggacag  atctcaatg  aattaacac  ctaggagaa  atattgctg  taatggagg  2040
attggccaa  catacagag  ctatcagaa  tatgttaaa  agaatggtg  agaaaaatt  2100
ctccctgga  ttgacctca  tcacaaaca  ctattcttc  tgaactttg  ccaggtgtg  2160
tgtggaacc  accggccag  gtatgcagt  aattccatt  aaacagatg  acacagtcc  2220
ggcaatttc  ggatcattg  gactttgca  aactctgct  agtttgcgg  tgcctttca  2280
tgccgcaag  actcataca  gaatccaga  aggaaatgt  gggtttggt  atcttcaca  2340
gaagtggag  atccatggc  ggactcgcc  aagccacag  aacaggaag  cttccctca  2400
agaacgtgg  ccccggaag  ttcttcagc  tcttggggg  aattcacag  gatgagcac  2460
agctaacaa  aatgaaatt  gattattaa  accgctgtg  atgaaaggg  agaaaacct  2520
cgatctagc  aatcaatca  ttcactgtg  aaataatta  cttccaacg  taatattac  2580
gttcacttc  ggttctcac  cagactgca  ctttcatgc  gtctgtaga  aacagtgtt  2640
acacttaaa  caggttatg  cttctgatc  agaggagga  gacgctgaa  acagttggg  2700
accaaagta  agatttgcc  ctcagcact  acttttgtt  gcaacattc  gctccttca  2760
aattctccc  aagaacccc  atgcatact  tggccttca  gctcctgca  tgtggaact  2820
attttacca  gcataaatt  ttcattcat  ccacatcat  ttagtttga  cactcttag  2880
gcttaaact  gagagtctg  aatggttcc  ccatttacc  acttgagtg  tgttgagac  2940
cttcagccc  ctacagatt  ttgagcaat  tcttgctct  gctgcccct  agacttagt  3000
ttttaaagg  tttgtagta  tgtataaaa  acattctat  tttaattat  aactacaca  3060
gaccaaata  accattgct  taggtaatc  ttgaatatt  acattatat  gccaagata  3120
atagttaag  agatctgta  catgatgtg  agatgaaaa  ttgaaactt  ttaagcctg  3180
aaatcatat  gctgaaaat  ttcaaacac  aactctggg  tgagcatta  cattgaaca  3240
ttg  3243



<210> 3361
<211> 749
<212> PRT
<213> Rattus norvegicus
<308> P07861
<400> 3361

Gly Arg Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Ala Pro Lys 
  1               5                  10                  15
Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser Val 
             20                  25                  30
Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu Tyr 
         35                  40                  45
Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser 
     50                  55                  60
Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Ser Ala Glu Pro Cys Thr 
 65                  70                  75                  80
Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val Ile 
                 85                  90                  95
Pro Glu Thr Ser Ser Arg Tyr Ser Asn Phe Asp Ile Leu Arg Asp Glu 
             100                105                110
Leu Glu Val Ile Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu Asp 
         115                120                125
Ile Val Ala Val Gln Lys Ala Lys Thr Leu Tyr Arg Ser Cys Ile Asn 
     130                135                140
Glu Ser Ala Ile Asp Ser Arg Gly Gly Gln Pro Leu Leu Thr Leu Leu 
 145                150                155                160
Pro Asp Ile Tyr Gly Trp Pro Val Ala Ser Gln Asn Trp Glu Gln Thr 
                 165                170                175
Tyr Gly Thr Ser Trp Thr Ala Glu Lys Ser Ile Ala Gln Leu Asn Ser 
             180                185                190
Lys Tyr Gly Lys Lys Val Leu Ile Asn Phe Phe Val Gly Thr Asp Asp 
         195                200                205
Lys Asn Ser Thr Gln His Ile Ile His Phe Asp Gln Pro Arg Leu Gly 
     210                215                220
Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala 
 225                230                235                240
Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile Arg 
                 245                250                255
Gln Glu Gln Arg Leu Pro Ile Asp Glu Asn Gln Leu Ser Leu Glu Met 
             260                265                270
Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Thr Lys 
         275                280                285
Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr Leu 
     290                295                300
Ala Lys Leu Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe 
 305                310                315                320
Ser Trp Ser Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile Asn 
                 325                330                335
Ile Gln Asn Glu Glu Glu Val Val Val Tyr Ala Pro Glu Tyr Leu Thr 
             340                345                350
Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Pro Arg Asp Leu Gln Asn 
         355                360                365
Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser Arg 
     370                375                380
Asn Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr 
 385                390                395                400
Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly 
                 405                410                415
Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala 
             420                425                430
Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg Glu 
         435                440                445
Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu Thr 
     450                455                460
Lys Lys Lys Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly 
 465                470                475                480
Tyr Pro Asp Asp Ile Ile Ser Asn Glu Asn Lys Leu Asn Asn Glu Tyr 
                 485                490                495
Leu Glu Leu Asn Tyr Lys Glu Glu Glu Tyr Phe Glu Asn Ile Ile Gln 
             500                505                510
Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys 
         515                520                525
Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala Phe 
     530                535                540
Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu Gln 
 545                550                555                560
Pro Pro Phe Phe Ser Ala Arg Gln Ser Asn Ser Leu Asn Tyr Gly Gly 
                 565                570                575
Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp Asn 
             580                585                590
Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr Gln 
         595                600                605
Gln Ser Ala Asn Asn Phe Lys Asp Gln Ser Gln Cys Met Val Tyr Gln 
     610                615                620
Tyr Gly Asn Phe Thr Trp Asp Leu Ala Gly Gly Gln His Leu Asn Gly 
 625                630                635                640
Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Ile Gly Gln 
                 645                650                655
Ala Tyr Arg Ala Tyr Gln Asn Tyr Val Lys Lys Asn Gly Glu Glu Lys 
             660                665                670
Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu Asn 
         675                680                685
Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn 
     690                695                700
Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile Gly 
 705                710                715                720
Thr Leu Gln Asn Ser Ala Glu Phe Ala Asp Ala Phe His Cys Arg Lys 
                 725                730                735
Asn Ser Tyr Met Asn Pro Glu Arg Lys Cys Arg Val Trp 
             740                745



<210> 3362
<211> 3181
<212> DNA
<213> Homo sapiens
<308> X07166
<400> 3362

gcaagtcag  aagtcagat  gatataact  atatcaaca  tccaaagcc  aagaagaaa  60
agcgatgga  tccactgga  atcagcctc  cggtccttg  cctgctcct  accatcata  120
ctgtgacaa  gatcgcact  tatgcaacc  acgatgatg  tatttgcaa  tcatcagac  180
gcataaaat  agctgctcg  ctgatccaa  acatggatg  caccactga  ccttgtaca  240
actttttca  atatgcttg  ggaggctgg  tgaaacgta  tgtcattcc  gagaccagc  300
cccgttacg  caactttga  attttaaga  atgaactag  agtcgtttt  aaagatgtc  360
ttcaagaac  caaaactga  gatatagta  cagtgcaga  agcaaaagc  ttgtacagg  420
cttgtataa  tgaatctgc  attgatagc  gaggtggag  acctctact  aaactgtta  480
cagacatat  tgggtggcc  gtagcaaca  aaaactggg  gcaaaaata  ggtgcttct  540
ggacagctg  aaaagctat  gcacaactg  attctaaat  tgggaaaaa  gtccttatt  600
atttgtttg  tggcactga  gataagaat  ctgtgaatc  tgtaattca  attgaccaa  660
ctcgacttg  cctcccttc  agagattac  atgaatgca  tggaatcta  aaagaggct  720
gtacagcat  tgtggattt  atgatttct  tggccagat  gattcgtca  gaagaaaga  780
tgcccatcg  tgaaaacca  cttgctttg  aaatgaata  agttatgga  ttggaaaaa  840
aaattgcca  tgctacggc  aaacctgaa  atcgaaatg  tccaatgct  ctgtataac  900
agatgacat  ggcccagat  caaaataac  tttcactag  gatcaatgg  aagccattc  960
gctggttga  tttcacaaa  gaaatcatg  caactgtga  tattagtat  acaaatgag  1020
aagatgtgg  tgtttatgc  ccagaatat  taaccaaac  taagcccat  cttaccaaa  1080
attctgcca  agatcttca  aatttaatg  cctggagat  cataatgga  cttgtaagc  1140
gcctcagcc  aacctacaa  gagtccaga  atgctttcc  caaggccct  tatggtaca  1200
cctcagaaa  agcaacttg  agacgttgt  caaactatg  caatgggaa  atggaaaat  1260
ctgtgggga  gctttatgt  gaagcagca  ttgctggag  gagtaaaca  gtggtcgag  1320
atttgattg  acagatccg  gaagttttt  ttcagactt  agatgacct  acttggatg  1380
atgccgaga  aaaaaagag  gctgaagaa  aggccttag  aattaaaga  aggatcggc  1440
atcctgatg  cattgtttc  aatgataac  aactgaata  tgagtacct  gagttgaac  1500
acaaagaag  tgaatactt  gagaacata  ttcaaaatt  gaaattcag  caaagtaaa  1560
aactgaaga  gctccgaga  aaggtggac  aagatgagt  gataagtgg  gcagctgta  1620
tcaatgcat  ttactcttc  ggaagaaat  agatagtct  cccagccgg  attctgcag  1680
cccccttct  tagtgccca  cagtccaac  cattgaact  tgggggcat  ggcatggtc  1740
taggacacg  aatcaccca  ggcttcgat  acaatggca  aaactttaa  aaagatgga  1800
acctcgttg  ctggtggac  caacagtct  caagtaact  taaggagca  tcccagtgc  1860
tggtgtatc  gtatggaaa  ttttcctgg  acctggcag  tggacagca  cttaatgga  1920
ttaatacac  gggagaaaa  attgctgat  atggaggtc  tggtcaagc  tacagagcc  1980
atcagaatt  tattaaaaa  aatggcgaa  aaaaattac  tcctggact  gacctaaat  2040
acaaacaac  atttttctt  aactttgca  aggtgtggt  tggaaccta  aggccagag  2100
atgcggtta  ctccattaa  acagatgtg  acagtccag  caatttcag  attattggg  2160
ctttgcaga  ctctgcaga  ttttcagaa  cctttcact  ccgcaagaa  tcatacatg  2220
atccagaaa  gaagtgccg  gtttggtga  cttcaaaag  agcattgca  cccttggct  2280
gacttgcca  caccacaga  atggggaat  ctctaatcg  aagaaaatg  gccctaggg  2340
tcactgtac  gacttgagg  tgattaaca  agagggcac  atcacaata  agataacat  2400
aggttgtcc  agaaagggt  tggagggag  aagggggtc  aaggtctat  aagtcaatc  2460
tttctcact  tgtacataa  gcttaattt  taaagataa  attactgtt  atttctgtt  2520
ctcatatgg  ctaccagtt  gctgatgtc  ctagaaaac  atgcaaaac  tttgaggta  2580
accaggatt  ctaatcaaa  gggaaaaga  gatgttgaa  aatacagtt  ggcaccaga  2640
gaacagtag  tgacactat  gtttaaaac  cattgccta  ctactagtt  ttactttta  2700
ttgcaacat  tacagtcct  caaaatcct  ccaaagaat  cttatacac  ttggggcct  2760
ggagcttac  tagttttaa  ctcattttt  ccatacatc  gttattcat  ctgtgatca  2820
ttattttaa  cactcttaa  gcaaaaaat  aatgtctaa  attgttttt  gttgtacct  2880
ctttgactg  tgctgagat  cttcaggct  cctgcaatt  tctaagcaa  ttcttgctc  2940
atctctcaa  acttggtat  tttcagaga  ttatataaa  gtaaaaata  taattttta  3000
atttaatta  taactacat  tatgagtaa  tattattat  ggtaatcaa  gaatattga  3060
gtttcagct  aaaataaac  gttgtgaac  aagatctat  aagcgatat  cagatgaaa  3120
tttgagact  tttaaactt  taaatcata  tgatgaaaa  atttaagca  aaactttag  3180
g  3181



<210> 3363
<211> 749
<212> PRT
<213> Homo sapiens
<308> P08473
<400> 3363

Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro Lys 
  1               5                  10                  15
Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser Val 
             20                  25                  30
Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu Tyr 
         35                  40                  45
Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser 
     50                  55                  60
Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys Thr 
 65                  70                  75                  80
Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val Ile 
                 85                  90                  95
Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu 
             100                105                110
Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu Asp 
         115                120                125
Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn 
     130                135                140
Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu 
 145                150                155                160
Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln Lys 
                 165                170                175
Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser 
             180                185                190
Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp Asp 
         195                200                205
Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu Gly 
     210                215                220
Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala 
 225                230                235                240
Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile Arg 
                 245                250                255
Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu Met 
             260                265                270
Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys 
         275                280                285
Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr Leu 
     290                295                300
Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe 
 305                310                315                320
Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile Ser 
                 325                330                335
Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu Thr 
             340                345                350
Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn 
         355                360                365
Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser Arg 
     370                375                380
Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr 
 385                390                395                400
Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly 
                 405                410                415
Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala 
             420                425                430
Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg Glu 
         435                440                445
Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu Thr 
     450                455                460
Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly 
 465                470                475                480
Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr 
                 485                490                495
Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln 
             500                505                510
Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys 
         515                520                525
Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala Phe 
     530                535                540
Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu Gln 
 545                550                555                560
Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly 
                 565                570                575
Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp Asn 
             580                585                590
Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr Gln 
         595                600                605
Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr Gln 
     610                615                620
Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn Gly 
 625                630                635                640
Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln 
                 645                650                655
Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys 
             660                665                670
Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu Asn 
         675                680                685
Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn 
     690                695                700
Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile Gly 
 705                710                715                720
Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg Lys 
                 725                730                735
Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp 
             740                745



<210> 3364
<211> 1840
<212> DNA
<213> Rattus norvegicus
<308> M16112
<400> 3364

ggagccgga  tcgccgccg  ccgagcgca  ccgagcgca  gccgagccc  atcgccacc  60
ccatggcca  cacggtgac  tgcacccgt  tcacggacg  gtaccagct  tacgaggat  120
ttggcaagg  ggctttctc  gtggtccga  gctgtgtca  gctctgcac  ggccatgag  180
atgcagcta  gatcattaa  accaagaag  tgtcagcta  agatcacca  aagctggag  240
gggaggctc  gatctgccg  ctgctgaag  attccaaca  tgtacgcct  catgacagc  300
tctctgaag  gggcttcca  tacctggtc  tcgacctgg  cactggtgg  gagctcttt  360
aagacattg  ggcgagaga  tactacagt  aggctgacg  cagtcactg  atccagcag  420
tcctggagg  tgttctcca  tgtcaccaa  tgggggtcg  ccacagaga  ctcaagcct  480
aaaacctgc  cctggccag  aaatgcaaa  gggccgcag  gaaactggc  gacttcggc  540
tggccatcg  ggttcaggg  gaccagcag  catggtttg  atttgcggg  acaccaggc  600
acctgtctc  cgaagttct  cggaaggag  cctatggca  accagtgga  atctgggca  660
gtggggtga  cctgtatat  ctgctggtg  gatacccac  tttctggga  gaggaccag  720
acaagctgt  ccagcagat  aaggctggg  cctatgact  cccatcccc  gagtgggac  780
ccgttaccc  tgaagccaa  aacctcatc  accagatgt  gaccatcaa  cccgccaag  840
gcatcacgg  ccacgaggc  ctgaagcac  catgggtct  ccaacgatc  acggtggcc  900
ccatgatgc  cagacagga  actgtggaa  gtctgaaga  gttcaatgc  aggaggaag  960
tcaagggag  catcctcac  actatgctg  ccacacgga  tttctcagt  ggcagacag  1020
ccaccgctc  ggccacaat  tccaccgcg  cctccggca  caccatggg  ctggtggaa  1080
aagccaaga  tttactcaa  aagaaagca  acggagtca  gccccagac  aacagcacc  1140
aaaacagct  ggccatcac  agccccaaa  gatccctcc  tcctgccgc  ctggagcct  1200
aaaccaccg  tatccataa  ccagtggac  gcattaagg  atcttccga  agcaccaac  1260
caaccatag  ggacgaaga  gccaaagcc  ggaagcagg  aatcatcaa  accacagag  1320
agctcatcg  ggccgtcaa  aacggcgac  ttgaggcct  tgcgaaaat  tgtgaccca  1380
gcctgacct  atttgagcc  gaagctctg  gcaacctgg  cgaagggat  gatttccac  1440
gattctact  tgagaacct  ctggccaag  acagcaagc  gatccacac  actatcctg  1500
acccgcacg  gcacgtcat  ggcgaggat  cagcctgca  cgcttacat  cgcctcaca  1560
agtacatcg  cggccaggg  agaccccgc  ccagccagt  cgaagagac  cgtgtgtgg  1620
accgccccg  cggcaagtg  cagaatgtc  atttccact  ctcgggcgc  ccagtggcc  1680
cactgcagt  agagctgcg  ctggtttca  cggacagag  tggtgtttg  agcccagcc  1740
ccctcgggc  cacggcctg  ctgtcgcat  tttgtgtct  cctcgtccc  tcccctggt  1800
cctgtgtct  cagaaaaac  agaccagat  tgatttgttt  1840



<210> 3365
<211> 542
<212> PRT
<213> Rattus norvegicus
<308> P08413
<400> 3365

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
  1               5                  10                  15
Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
             20                  25                  30
Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
         115                120                125
Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
             180                185                190
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Val Gly Arg Gln Thr 
 305                310                315                320
Thr Ala Pro Ala Thr Met Ser Thr Ala Ala Ser Gly Thr Thr Met Gly 
                 325                330                335
Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val 
             340                345                350
Lys Pro Gln Thr Asn Ser Thr Lys Asn Ser Ser Ala Ile Thr Ser Pro 
         355                360                365
Lys Gly Ser Leu Pro Pro Ala Ala Leu Glu Pro Gln Thr Thr Val Ile 
     370                375                380
His Asn Pro Val Asp Gly Ile Lys Glu Ser Ser Asp Ser Thr Asn Thr 
 385                390                395                400
Thr Ile Glu Asp Glu Asp Ala Lys Ala Arg Lys Gln Glu Ile Ile Lys 
                 405                410                415
Thr Thr Glu Gln Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu Ala 
             420                425                430
Tyr Ala Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu Ala 
         435                440                445
Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
     450                455                460
Asn Leu Leu Ala Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu Asn 
 465                470                475                480
Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile 
                 485                490                495
Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln 
             500                505                510
Ser Glu Glu Thr Arg Val Trp His Arg Pro Asp Gly Lys Trp Gln Asn 
         515                520                525
Val His Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu Gln 
     530                535                540



<210> 3366
<211> 1577
<212> DNA
<213> Homo sapiens
<308> AF081924
<400> 3366

gccatggcc  ccacggtga  ctgcacccg  ttcaccgac  agtaccagc  ctacgagga  60
attggcaag  gggctttct  tgtggtccg  cgctgtgtc  agctctgca  cggccatga  120
tatgcagcc  agatcatca  caccaagaa  ctgtcagcc  gagatcacc  gaagctgga  180
agagaggct  ggatctgcc  ccttctgaa  cattccaac  tcgtgcgtc  ccacgacag  240
atctccgag  agggcttcc  ctacctggt  ttcgatctg  tcactggtg  ggagctctt  300
gaagacatt  tggcgagag  gtactacag  gaggctgat  ccagtcact  tatccagca  360
atcctggag  ccgttctcc  ttgtcacca  atgggggtc  tccacagag  cctcaagcc  420
gagaacctg  ttctggcca  caagtgcaa  ggggctgca  tgaagctgg  agacttcgg  480
ctagctatc  aggtgcagg  ggaccagca  gcatggttt  gtttcgctg  cacaccagg  540
tacctgtcc  ctgaggtcc  tcgcaaaga  gcgtatggc  agcctgtgg  catctgggc  600
tgtggggtg  tcctgtaca  cctgctcgt  ggctaccca  ccttctggg  cgaggacca  660
cacaagctg  accagcaga  caaggctgg  gcctatgac  tcccgtccc  tgagtggga  720
accgtcact  ctgaagcca  aaacctcat  aaccagatg  tgaccatca  ccctgccaa  780
cgcatcaca  cccatgagg  cctgaagca  ccgtgggtc  gccaacgct  cacggtagc  840
tccatgatg  acagacagg  gactgtgga  tgtctgaaa  agttcaatg  caggagaaa  900
ctcaaggga  ccatcctca  caccatgct  gccacacgg  atttctcag  gggcagaca  960
accaccgct  cggccacaa  gtccaccgc  gcctccggc  ccaccatgg  gctggtgga  1020
caagccaag  gtttactca  caagaaagc  gatggagtc  aggagcctc  aaccaccgt  1080
atccataac  cagtggacg  gattaagga  tcttctgac  gtgccaata  caccataga  1140
gatgaagac  ctaaagccc  gaagcagga  atcattaag  ccacggagc  gctcatcga  1200
gccgtcaac  acggtgact  tgaggccta  gcattctac  tcgagaacc  gctggccaa  1260
aacagcaag  cgatccaca  gaccatcct  aacccacac  tgcacgtca  tggagagga  1320
gccgcctgc  tcgcttaca  ccggctcac  cagtacatt  acgggcagg  ccggccccg  1380
accagccag  ctgaggaga  ccgcgtgtg  caccgccgc  acggcaagt  gcagaacgt  1440
cacttccac  gctcgggcg  gcctgtggc  ccgctgcag  gaagagctg  gccctggtt  1500
cgccggaca  agttggtgt  tggagcccg  ctgccctcg  gcacacggc  tgcctgtcg  1560
atgtttgtg  ctgcctc  1577



<210> 3367
<211> 664
<212> PRT
<213> Homo sapiens
<308> Q9UNX7
<400> 3367

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
  1               5                  10                  15
Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
             20                  25                  30
Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
         115                120                125
Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
             180                185                190
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Val Gly Arg Gln Thr 
 305                310                315                320
Thr Ala Pro Ala Thr Met Ser Thr Ala Ala Ser Gly Thr Thr Met Gly 
                 325                330                335
Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val 
             340                345                350
Lys Pro Gln Thr Asn Ser Thr Lys Asn Ser Ala Ala Ala Thr Ser Pro 
         355                360                365
Lys Gly Thr Leu Pro Pro Ala Ala Leu Glu Pro Gln Thr Thr Val Ile 
     370                375                380
His Asn Pro Val Asp Gly Ile Lys Glu Ser Ser Asp Ser Ala Asn Thr 
 385                390                395                400
Thr Ile Glu Asp Glu Asp Ala Lys Ala Pro Arg Val Pro Asp Ile Leu 
                 405                410                415
Ser Ser Val Arg Arg Gly Ser Gly Ala Arg Ser Arg Gly Ala Pro Ala 
             420                425                430
Cys Pro Ser Pro Ala Pro Phe Ser Pro Leu Pro Ala Pro Ser Pro Arg 
         435                440                445
Ile Ser Asp Ile Leu Asn Ser Val Arg Arg Gly Ser Gly Thr Pro Glu 
     450                455                460
Ala Glu Gly Pro Leu Ser Ala Gly Pro Pro Pro Cys Leu Ser Pro Ala 
 465                470                475                480
Leu Leu Gly Pro Leu Ser Ser Pro Ser Pro Arg Ile Ser Asp Ile Leu 
                 485                490                495
Asn Ser Val Arg Arg Gly Ser Gly Thr Pro Glu Ala Glu Ala Pro Arg 
             500                505                510
Gln Trp Pro Pro Pro Cys Pro Ser Pro Thr Ile Pro Gly Pro Leu Pro 
         515                520                525
Thr Pro Ser Arg Lys Gln Glu Ile Ile Lys Thr Thr Glu Gln Leu Ile 
     530                535                540
Glu Ala Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile Cys Asp 
 545                550                555                560
Pro Gly Leu Thr Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu 
                 565                570                575
Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala Lys Asn 
             580                585                590
Ser Lys Pro Ile His Thr Thr Ile Leu Asn Pro His Val His Val Ile 
         595                600                605
Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln Tyr Ile 
     610                615                620
Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln Ser Glu Glu Thr Arg Val 
 625                630                635                640
Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Cys Ser 
                 645                650                655
Gly Ala Pro Val Ala Pro Leu Gln 
             660



<210> 3368
<211> 1840
<212> DNA
<213> Rattus norvegicus
<308> M16112
<400> 3368

ggagccgga  tcgccgccg  ccgagcgca  ccgagcgca  gccgagccc  atcgccacc  60
ccatggcca  cacggtgac  tgcacccgt  tcacggacg  gtaccagct  tacgaggat  120
ttggcaagg  ggctttctc  gtggtccga  gctgtgtca  gctctgcac  ggccatgag  180
atgcagcta  gatcattaa  accaagaag  tgtcagcta  agatcacca  aagctggag  240
gggaggctc  gatctgccg  ctgctgaag  attccaaca  tgtacgcct  catgacagc  300
tctctgaag  gggcttcca  tacctggtc  tcgacctgg  cactggtgg  gagctcttt  360
aagacattg  ggcgagaga  tactacagt  aggctgacg  cagtcactg  atccagcag  420
tcctggagg  tgttctcca  tgtcaccaa  tgggggtcg  ccacagaga  ctcaagcct  480
aaaacctgc  cctggccag  aaatgcaaa  gggccgcag  gaaactggc  gacttcggc  540
tggccatcg  ggttcaggg  gaccagcag  catggtttg  atttgcggg  acaccaggc  600
acctgtctc  cgaagttct  cggaaggag  cctatggca  accagtgga  atctgggca  660
gtggggtga  cctgtatat  ctgctggtg  gatacccac  tttctggga  gaggaccag  720
acaagctgt  ccagcagat  aaggctggg  cctatgact  cccatcccc  gagtgggac  780
ccgttaccc  tgaagccaa  aacctcatc  accagatgt  gaccatcaa  cccgccaag  840
gcatcacgg  ccacgaggc  ctgaagcac  catgggtct  ccaacgatc  acggtggcc  900
ccatgatgc  cagacagga  actgtggaa  gtctgaaga  gttcaatgc  aggaggaag  960
tcaagggag  catcctcac  actatgctg  ccacacgga  tttctcagt  ggcagacag  1020
ccaccgctc  ggccacaat  tccaccgcg  cctccggca  caccatggg  ctggtggaa  1080
aagccaaga  tttactcaa  aagaaagca  acggagtca  gccccagac  aacagcacc  1140
aaaacagct  ggccatcac  agccccaaa  gatccctcc  tcctgccgc  ctggagcct  1200
aaaccaccg  tatccataa  ccagtggac  gcattaagg  atcttccga  agcaccaac  1260
caaccatag  ggacgaaga  gccaaagcc  ggaagcagg  aatcatcaa  accacagag  1320
agctcatcg  ggccgtcaa  aacggcgac  ttgaggcct  tgcgaaaat  tgtgaccca  1380
gcctgacct  atttgagcc  gaagctctg  gcaacctgg  cgaagggat  gatttccac  1440
gattctact  tgagaacct  ctggccaag  acagcaagc  gatccacac  actatcctg  1500
acccgcacg  gcacgtcat  ggcgaggat  cagcctgca  cgcttacat  cgcctcaca  1560
agtacatcg  cggccaggg  agaccccgc  ccagccagt  cgaagagac  cgtgtgtgg  1620
accgccccg  cggcaagtg  cagaatgtc  atttccact  ctcgggcgc  ccagtggcc  1680
cactgcagt  agagctgcg  ctggtttca  cggacagag  tggtgtttg  agcccagcc  1740
ccctcgggc  cacggcctg  ctgtcgcat  tttgtgtct  cctcgtccc  tcccctggt  1800
cctgtgtct  cagaaaaac  agaccagat  tgatttgttt  1840



<210> 3369
<211> 542
<212> PRT
<213> Rattus norvegicus
<308> P08413
<400> 3369

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
  1               5                  10                  15
Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
             20                  25                  30
Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
         115                120                125
Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
             180                185                190
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Val Gly Arg Gln Thr 
 305                310                315                320
Thr Ala Pro Ala Thr Met Ser Thr Ala Ala Ser Gly Thr Thr Met Gly 
                 325                330                335
Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val 
             340                345                350
Lys Pro Gln Thr Asn Ser Thr Lys Asn Ser Ser Ala Ile Thr Ser Pro 
         355                360                365
Lys Gly Ser Leu Pro Pro Ala Ala Leu Glu Pro Gln Thr Thr Val Ile 
     370                375                380
His Asn Pro Val Asp Gly Ile Lys Glu Ser Ser Asp Ser Thr Asn Thr 
 385                390                395                400
Thr Ile Glu Asp Glu Asp Ala Lys Ala Arg Lys Gln Glu Ile Ile Lys 
                 405                410                415
Thr Thr Glu Gln Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu Ala 
             420                425                430
Tyr Ala Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu Ala 
         435                440                445
Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
     450                455                460
Asn Leu Leu Ala Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu Asn 
 465                470                475                480
Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile 
                 485                490                495
Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln 
             500                505                510
Ser Glu Glu Thr Arg Val Trp His Arg Pro Asp Gly Lys Trp Gln Asn 
         515                520                525
Val His Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu Gln 
     530                535                540



<210> 3370
<211> 1577
<212> DNA
<213> Homo sapiens
<308> AF081924
<400> 3370

gccatggcc  ccacggtga  ctgcacccg  ttcaccgac  agtaccagc  ctacgagga  60
attggcaag  gggctttct  tgtggtccg  cgctgtgtc  agctctgca  cggccatga  120
tatgcagcc  agatcatca  caccaagaa  ctgtcagcc  gagatcacc  gaagctgga  180
agagaggct  ggatctgcc  ccttctgaa  cattccaac  tcgtgcgtc  ccacgacag  240
atctccgag  agggcttcc  ctacctggt  ttcgatctg  tcactggtg  ggagctctt  300
gaagacatt  tggcgagag  gtactacag  gaggctgat  ccagtcact  tatccagca  360
atcctggag  ccgttctcc  ttgtcacca  atgggggtc  tccacagag  cctcaagcc  420
gagaacctg  ttctggcca  caagtgcaa  ggggctgca  tgaagctgg  agacttcgg  480
ctagctatc  aggtgcagg  ggaccagca  gcatggttt  gtttcgctg  cacaccagg  540
tacctgtcc  ctgaggtcc  tcgcaaaga  gcgtatggc  agcctgtgg  catctgggc  600
tgtggggtg  tcctgtaca  cctgctcgt  ggctaccca  ccttctggg  cgaggacca  660
cacaagctg  accagcaga  caaggctgg  gcctatgac  tcccgtccc  tgagtggga  720
accgtcact  ctgaagcca  aaacctcat  aaccagatg  tgaccatca  ccctgccaa  780
cgcatcaca  cccatgagg  cctgaagca  ccgtgggtc  gccaacgct  cacggtagc  840
tccatgatg  acagacagg  gactgtgga  tgtctgaaa  agttcaatg  caggagaaa  900
ctcaaggga  ccatcctca  caccatgct  gccacacgg  atttctcag  gggcagaca  960
accaccgct  cggccacaa  gtccaccgc  gcctccggc  ccaccatgg  gctggtgga  1020
caagccaag  gtttactca  caagaaagc  gatggagtc  aggagcctc  aaccaccgt  1080
atccataac  cagtggacg  gattaagga  tcttctgac  gtgccaata  caccataga  1140
gatgaagac  ctaaagccc  gaagcagga  atcattaag  ccacggagc  gctcatcga  1200
gccgtcaac  acggtgact  tgaggccta  gcattctac  tcgagaacc  gctggccaa  1260
aacagcaag  cgatccaca  gaccatcct  aacccacac  tgcacgtca  tggagagga  1320
gccgcctgc  tcgcttaca  ccggctcac  cagtacatt  acgggcagg  ccggccccg  1380
accagccag  ctgaggaga  ccgcgtgtg  caccgccgc  acggcaagt  gcagaacgt  1440
cacttccac  gctcgggcg  gcctgtggc  ccgctgcag  gaagagctg  gccctggtt  1500
cgccggaca  agttggtgt  tggagcccg  ctgccctcg  gcacacggc  tgcctgtcg  1560
atgtttgtg  ctgcctc  1577



<210> 3371
<211> 664
<212> PRT
<213> Homo sapiens
<308> Q9UNX7
<400> 3371

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
  1               5                  10                  15
Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
             20                  25                  30
Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
         115                120                125
Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
             180                185                190
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Val Gly Arg Gln Thr 
 305                310                315                320
Thr Ala Pro Ala Thr Met Ser Thr Ala Ala Ser Gly Thr Thr Met Gly 
                 325                330                335
Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val 
             340                345                350
Lys Pro Gln Thr Asn Ser Thr Lys Asn Ser Ala Ala Ala Thr Ser Pro 
         355                360                365
Lys Gly Thr Leu Pro Pro Ala Ala Leu Glu Pro Gln Thr Thr Val Ile 
     370                375                380
His Asn Pro Val Asp Gly Ile Lys Glu Ser Ser Asp Ser Ala Asn Thr 
 385                390                395                400
Thr Ile Glu Asp Glu Asp Ala Lys Ala Pro Arg Val Pro Asp Ile Leu 
                 405                410                415
Ser Ser Val Arg Arg Gly Ser Gly Ala Arg Ser Arg Gly Ala Pro Ala 
             420                425                430
Cys Pro Ser Pro Ala Pro Phe Ser Pro Leu Pro Ala Pro Ser Pro Arg 
         435                440                445
Ile Ser Asp Ile Leu Asn Ser Val Arg Arg Gly Ser Gly Thr Pro Glu 
     450                455                460
Ala Glu Gly Pro Leu Ser Ala Gly Pro Pro Pro Cys Leu Ser Pro Ala 
 465                470                475                480
Leu Leu Gly Pro Leu Ser Ser Pro Ser Pro Arg Ile Ser Asp Ile Leu 
                 485                490                495
Asn Ser Val Arg Arg Gly Ser Gly Thr Pro Glu Ala Glu Ala Pro Arg 
             500                505                510
Gln Trp Pro Pro Pro Cys Pro Ser Pro Thr Ile Pro Gly Pro Leu Pro 
         515                520                525
Thr Pro Ser Arg Lys Gln Glu Ile Ile Lys Thr Thr Glu Gln Leu Ile 
     530                535                540
Glu Ala Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile Cys Asp 
 545                550                555                560
Pro Gly Leu Thr Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu 
                 565                570                575
Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala Lys Asn 
             580                585                590
Ser Lys Pro Ile His Thr Thr Ile Leu Asn Pro His Val His Val Ile 
         595                600                605
Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln Tyr Ile 
     610                615                620
Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln Ser Glu Glu Thr Arg Val 
 625                630                635                640
Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Cys Ser 
                 645                650                655
Gly Ala Pro Val Ala Pro Leu Gln 
             660



<210> 3372
<211> 587
<212> DNA
<213> Rattus norvegicus
<308> M17412
<400> 3372

gcggctgga  attgtctta  gttatatag  agaaatgct  cctcgcagc  aaggttaac  60
aggaacact  acttgaaga  gatcaatgg  ttctgcacc  agccacaag  aagtcccaa  120
gctccaacc  agtcttaca  acacagggt  ccgcttcac  agcccacag  cttcgagaa  180
aagattctg  tgtggtcag  ccgcttcaa  aaggaggaa  agatcccag  gacaatctc  240
tttgagatg  ttgacgctg  aaagaacaa  atccgggtg  aggtcagct  tttaatgat  300
gccctaaca  tggcaggat  cgtctatat  gttattgag  gcaagaagg  tgcaaaaag  360
catgatctt  ttcgaactg  aaaggaaag  ccgtctgtg  gaggaggca  ctatgaagg  420
caaagcgga  tagacgtat  tgtgctgga  ttggaaaag  caggagtac  gttgcaaca  480
gaagcctgc  ttagaagga  aagggctgg  gatttagct  agtggtaga  cgcttacct  540
ggaagcgca  ggccctggg  tcggtcccc  gctccgaaa  aataaaa  587



<210> 3373
<211> 175
<212> PRT
<213> Rattus norvegicus
<308> AAA42232
<400> 3373

Ala Ala Gly His Cys Leu Arg Leu Tyr Arg Arg Asn Ala Ser Ser Gln 
  1               5                  10                  15
Leu Arg Leu Thr Arg Asn Thr Asp Leu Lys Arg Ile Asn Gly Phe Cys 
             20                  25                  30
Thr Lys Pro Gln Glu Ser Pro Lys Ala Pro Thr Gln Ser Tyr Arg His 
         35                  40                  45
Arg Val Pro Leu His Lys Pro Thr Asp Phe Glu Lys Lys Ile Leu Leu 
     50                  55                  60
Trp Ser Gly Arg Phe Lys Lys Glu Glu Glu Ile Pro Glu Thr Ile Ser 
 65                  70                  75                  80
Phe Glu Met Leu Asp Ala Ala Lys Asn Lys Ile Arg Val Lys Val Ser 
                 85                  90                  95
Tyr Leu Met Ile Ala Leu Thr Val Ala Gly Cys Val Tyr Met Val Ile 
             100                105                110
Glu Gly Lys Lys Ala Ala Lys Arg His Asp Leu Phe Arg Thr Gly Lys 
         115                120                125
Glu Ser Pro Ser Val Arg Gly Gly Ser Tyr Glu Gly Gln Ser Gly Leu 
     130                135                140
Asp Val Phe Val Leu Asp Leu Glu Lys Pro Gly Val Arg Leu Gln Gln 
 145                150                155                160
Glu Ala Cys Phe Arg Arg Ile Arg Ala Gly Asp Leu Ala Gln Trp 
                 165                170                175



<210> 3374
<211> 1215
<212> DNA
<213> Homo sapiens
<308> NM_014367
<400> 3374

gtgacattg  gctcaccag  gccaccgtc  ccggcgaag  tctgcgctg  tcggcggag  60
gcaagtggc  atggggagc  tcagcggtc  gcgcctggc  gcaggaagc  gttttaggt  120
atgtgaaag  gatgtttcc  catctctaa  gcttaccag  agctctgat  tgaagagaa  180
aaatggatt  tgcacaaaa  cacaggaaa  tcccggagc  ccattcccg  acttacaac  240
gagtgcctt  acacaaacc  acggattgg  agaaaaaga  cctcatatg  tcaggtcgc  300
tcaaaagga  gatgaaatc  cagagactg  ctcgttgga  atgcttgat  ctgcaaaga  360
caagatgcg  gtgaagatc  gctatctaa  gattgccct  acggtggta  gatgcatct  420
tcattggtt  ttgagggca  gaagcttgc  caaagaccg  gactttaac  agcttggac  480
tttagaaaa  aaagctcgt  tgaaagaag  aagcagcta  gaaggccaa  acagattac  540
aaaggtatc  gtgttggtt  ggattttga  aatccagga  ttatgtttt  acgtgcctg  600
attaaaaag  atgtggtat  aggatccat  tcataaagt  tgatttgcc  aaacctgta  660
catttccgt  tttctgctg  agaagtaga  ataaatttt  ttaaataat  actgtgttt  720
attgttttg  tccaagtca  gtgtagcct  tcagccttt  ggagaaaaa  gaaacaatt  780
atttcaact  gaataccaa  tcttcagag  agcaggtac  atatcttac  tctcttccc  840
ttatcaaag  aacctctcc  caggcgaac  cattttgag  agataagga  ggccagttg  900
gtatatggc  caggtgcag  ttggagggc  agccttctc  aatgtcctg  tgtactggt  960
gggaggctg  cccctaata  agcgagcgc  gagaagcag  cagaccaca  tctataatc  1020
ttgaacatg  tggcagatg  aggctttta  gagaatagt  ttttaaaca  tctgacaag  1080
tccagccag  aatttctaa  gacttagaa  tcccagtgt  atggagttg  ttgggggtc  1140
acacaagtc  cctcttagc  tcatgcctt  gaattctca  ctgggctgt  tttcttacc  1200
cctgagaaa  taaat  1215



<210> 3375
<211> 190
<212> PRT
<213> Homo sapiens
<308> NP_055182
<400> 3375

Met Gly Ser Leu Ser Gly Leu Arg Leu Ala Ala Gly Ser Cys Phe Arg 
  1               5                  10                  15
Leu Cys Glu Arg Asp Val Ser Ser Ser Leu Arg Leu Thr Arg Ser Ser 
             20                  25                  30
Asp Leu Lys Arg Ile Asn Gly Phe Cys Thr Lys Pro Gln Glu Ser Pro 
         35                  40                  45
Gly Ala Pro Phe Pro His Leu Gln Gln Ser Ala Phe Thr Gln Thr Tyr 
     50                  55                  60
Gly Leu Ala Glu Lys Asp Pro His Met Val Arg Ser Leu Gln Lys Glu 
 65                  70                  75                  80
Asp Glu Ile Pro Glu Thr Val Ser Leu Glu Met Leu Asp Ala Ala Lys 
                 85                  90                  95
Asn Lys Met Arg Val Lys Ile Ser Tyr Leu Met Ile Ala Leu Thr Val 
             100                105                110
Val Gly Cys Ile Phe His Trp Leu Leu Arg Ala Arg Ser Leu Pro Lys 
         115                120                125
Asp Arg Asp Phe Asn Gln Leu Gly Pro Leu Glu Lys Lys Ala Arg Leu 
     130                135                140
Lys Glu Gly Ser Ser Tyr Glu Gly Gln Asn Arg Leu Pro Lys Val Ser 
 145                150                155                160
Val Leu Val Gly Ile Leu Lys Ile Gln Glu Leu Cys Phe Asn Val Pro 
                 165                170                175
Val Leu Lys Arg Met Trp Tyr Glu Asp Pro Phe His Lys Val 
             180                185                190



<210> 3376
<211> 1945
<212> DNA
<213> Rattus norvegicus
<308> M17527
<400> 3376

gcggcggcg  taccgagcc  agcggtcgc  gggactcgc  ggcgcggat  gtagagcgt  60
gcgggcggg  acggccgcc  gaggcggcg  cgtatcggt  agcagacct  gcctccagc  120
tgccggagc  gaggaccta  cggggccgc  tccgggcca  cctctcccc  ctctgccag  180
cggccccgg  gccgagggc  cggcgacgc  cggccacca  gggctgcac  ctgagcgct  240
aggacaagg  ggccgtgga  cgcagcaag  tgatcgacc  caacctccg  gaggacgga  300
agaaggcag  gcgcgaggt  aagctgctg  tgctgggtg  tggtgaatc  gggaagagc  360
caattgtga  gcagatgaa  attatccac  aggctggct  ctcagagga  gagtgtaag  420
agtacaaag  agtggtcta  agcaacacc  tccagtcca  cattgccat  attagagcc  480
tggggagat  gaaaatcga  tttggagac  ctgctcgtg  ggatgatgc  cgccaactc  540
tcgtgcttg  tggggctgc  gaggaaggc  ttatgaccg  ggagctcgc  ggcgtcata  600
agagactgt  gaaggacag  ggtgtgcaa  cctgcttca  cagatcccg  gagtaccag  660
tgaacgatt  ggcggcgta  tacctgaat  acttggaca  aatagcaca  ccaaattac  720
tcccaaccc  gcaggatgt  ctcagaact  gagtgaaaa  gacgggaat  gtggaaacc  780
actttactt  caaagatct  cattttaaa  tgtttgacg  gggaggcca  agatcagag  840
ggaagaagt  gattcactg  tttgaaggc  tgactgcca  catcttctg  gtggccctg  900
gtgactatg  cctggttct  gctgaggat  aagaaatga  ccggatgca  gaaagcatg  960
agctgttcg  tagcatatg  aacaacaag  ggtttacgg  cacatccat  atccttttc  1020
tgaacaaga  ggacctctt  gaagagaag  tcaaaaaga  tcccctcac  atatgctat  1080
cagaatatg  aggctcaaa  acatatgaa  aggcggctg  gtatatcca  tgtcagttt  1140
aagacctca  taaaaggaa  gacacaaag  aaatttaca  ccacttcac  tgcgccacg  1200
atacgaaga  tgtgcagtt  gtgttcgat  ctgtaacgg  cgtcatcat  aagaataac  1260
taaaagact  tggtctctt  taagctctg  agtggggta  taaaaatgc  ttttcaaac  1320
agacgagta  ttatatatg  atctctcta  attagagtc  cccagcaac  gagaatgta  1380
tgtacagca  atgcatcct  gacctgacc  gagttctga  caaagttgt  ctgtatcgt  1440
tctttaata  aaggacctt  cgagaaggc  aaagatggt  ctggagtgt  agagggagg  1500
ttgatgttg  agctggggc  ctagtgtac  gatgatttc  gtgtaagtg  aaatatgca  1560
atgtaagat  tatttataa  ttctgattt  ccacgttat  tttatgttg  aagagtggc  1620
acttatggt  ctagtgcga  ggctttggg  aaacataac  gttaagtac  ttgtacgga  1680
tgacagatt  gttctgtgt  tggcagttt  gatcagctt  atttatgtt  gtaccccta  1740
attttaggc  ccataatta  cattaggaa  tgtcaaccc  cttaccctg  ttctatgtt  1800
acttatact  ataaaatgt  atttgtata  acgttgcac  gactatttt  gtaccatga  1860
ttgtataca  gcttttgat  catagggaa  tagtttgag  ttcattact  tatgtcaaa  1920
atgacttct  ttgcattag  tattc  1945



<210> 3377
<211> 353
<212> PRT
<213> Rattus norvegicus
<308> P10824
<400> 3377

Gly Cys Thr Leu Ser Ala Glu Asp Lys Ala Ala Val Glu Arg Ser Lys 
  1               5                  10                  15
Met Ile Asp Arg Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg Glu 
             20                  25                  30
Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile 
         35                  40                  45
Val Lys Gln Met Lys Ile Ile His Glu Ala Gly Tyr Ser Glu Glu Glu 
     50                  55                  60
Cys Lys Gln Tyr Lys Ala Val Val Tyr Ser Asn Thr Ile Gln Ser Ile 
 65                  70                  75                  80
Ile Ala Ile Ile Arg Ala Met Gly Arg Leu Lys Ile Asp Phe Gly Asp 
                 85                  90                  95
Ala Ala Arg Ala Asp Asp Ala Arg Gln Leu Phe Val Leu Ala Gly Ala 
             100                105                110
Ala Glu Glu Gly Phe Met Thr Ala Glu Leu Ala Gly Val Ile Lys Arg 
         115                120                125
Leu Trp Lys Asp Ser Gly Val Gln Ala Cys Phe Asn Arg Ser Arg Glu 
     130                135                140
Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Asp Arg 
 145                150                155                160
Ile Ala Gln Pro Asn Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg Thr 
                 165                170                175
Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys Asp 
             180                185                190
Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys 
         195                200                205
Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys Val 
     210                215                220
Ala Leu Ser Asp Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met Asn 
 225                230                235                240
Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn Lys 
                 245                250                255
Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp Leu 
             260                265                270
Phe Glu Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Tyr Pro Glu 
         275                280                285
Tyr Ala Gly Ser Asn Thr Tyr Glu Glu Ala Ala Ala Tyr Ile Gln Cys 
     290                295                300
Gln Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr Thr 
 305                310                315                320
His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe Asp 
                 325                330                335
Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly Leu 
             340                345                350
Phe 
         355



<210> 3378
<211> 1802
<212> DNA
<213> Homo sapiens
<308> AF055013
<400> 3378

gctttcggc  ccatgggct  cacgctgag  gccgaggac  aggcggcgg  ggagcggag  60
aagatgatc  accgcaacc  ccgtgagga  ggcgagaag  cggcgcgcg  ggtcaagct  120
ctgctgctc  gtgctggtg  atctggtaa  agtacaatt  tgaagcaga  gaaaattat  180
catgaagct  gttattcag  agaggagtg  aaacaatac  aagcagtgg  ctacagtaa  240
accatccag  caattattg  tatcattag  gctatgggg  ggttgaaga  agactttgg  300
gactcagcc  gggcggatg  tgcacgcca  ctctttgtg  tagctggag  tgctgaaga  360
ggctttatg  ctgcagaac  tgctggagt  ataaagaga  tgtggaaag  tagtggtgt  420
caagcctgt  tcaacagat  ccgagagta  cagcttaat  attctgcag  atactattt  480
aatgacttg  acagaatag  tcaaccaaa  tacatcccg  ctcaacaag  tgttctcag  540
actagagtg  aaactacag  aattgttga  acccatttt  ctttcaaag  tcttcattt  600
aaaatgttt  atgtgggag  tcagagatc  gagcggaag  agtggattc  ttgcttcga  660
ggagtgacg  cgatcatct  ctgtgtagc  ctgagtgac  acgacctgg  tctagctga  720
gatgaagaa  tgaaccgaa  gcatgaaag  atgaaattg  ttgacagca  atgtaacaa  780
aagtggttt  cagatacat  cattatact  tttctaaac  agaaggatc  ctttgaaga  840
aaaatcaaa  agagccctc  cactatatg  tatccagaa  atgcaggat  aaacacata  900
gaagaggca  ctgcatata  tcaatgtca  tttgaagac  tcaataaaa  aaaggacac  960
aaggaaata  acacccact  cacatgtgc  acagatact  agaatgtgc  gtttgtttt  1020
gatgctgta  cagatgtca  cataaaaaa  aatctaaaa  attgtggtc  cttttaagt  1080
ttgcagttc  tggtaaaat  cattttcaa  ccaaatgag  acttatata  ggatctctg  1140
agactagag  cttgcagca  cacagaatg  aatataagg  aaatgcatc  gggacttga  1200
caaagttgt  ctgttttgt  tttttaact  aaagtaaca  aaggacctt  cttaaatgt  1260
acagatggt  ctgcagtgt  aaactgaag  acagtgtta  agctgggct  tagtatatt  1320
atgatttct  cataagtgt  aatatgcaa  tgtatgtat  catgtattt  tgactttag  1380
tttcgacat  atttttagg  tttaagagt  gcaacttag  attttaggg  gatggcttt  1440
gaaataaca  aaatatacc  tgtactgaa  gacagacta  tactacgtt  gccagtttt  1500
aacagcttt  tttatgttc  tgtcctgta  atttttaag  acagtaatt  atattagga  1560
acattacag  ccttatcta  atcatatgt  tacttgtat  aataaaaat  ttatttgta  1620
aaacattgc  cagactatt  taataacat  atttgttct  taaatttta  gtgttttat  1680
gaaatgttc  taagatgaa  acacctgcc  ttggatcaa  tatttaaac  ttgtatgca  1740
tttgatttt  cctacttta  gaaaataaa  taatttaat  ttaaaaaaa  aaaaaaaaa  1800
aa  1802



<210> 3379
<211> 353
<212> PRT
<213> Homo sapiens
<308> P04898
<400> 3379

Gly Cys Thr Leu Ser Ala Glu Asp Lys Ala Ala Val Glu Arg Ser Lys 
  1               5                  10                  15
Met Ile Asp Arg Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg Glu 
             20                  25                  30
Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile 
         35                  40                  45
Val Lys Gln Met Lys Ile Ile His Glu Ala Gly Tyr Ser Glu Glu Glu 
     50                  55                  60
Cys Lys Gln Tyr Lys Ala Val Val Tyr Ser Asn Thr Ile Gln Ser Ile 
 65                  70                  75                  80
Ile Ala Ile Ile Arg Ala Met Gly Arg Leu Lys Ile Asp Phe Gly Asp 
                 85                  90                  95
Ser Ala Arg Ala Asp Asp Ala Arg Gln Leu Phe Val Leu Ala Gly Ala 
             100                105                110
Ala Glu Glu Gly Phe Met Thr Ala Glu Leu Ala Gly Val Ile Lys Arg 
         115                120                125
Leu Trp Lys Asp Ser Gly Val Gln Ala Cys Phe Asn Arg Ser Arg Glu 
     130                135                140
Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Asp Arg 
 145                150                155                160
Ile Ala Gln Pro Asn Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg Thr 
                 165                170                175
Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys Asp 
             180                185                190
Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys 
         195                200                205
Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys Val 
     210                215                220
Ala Leu Ser Asp Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met Asn 
 225                230                235                240
Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn Lys 
                 245                250                255
Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp Leu 
             260                265                270
Phe Glu Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Tyr Pro Glu 
         275                280                285
Tyr Ala Gly Ser Asn Thr Tyr Glu Glu Ala Ala Ala Tyr Ile Gln Cys 
     290                295                300
Gln Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr Thr 
 305                310                315                320
His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe Asp 
                 325                330                335
Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly Leu 
             340                345                350
Phe 
         355



<210> 3380
<211> 1945
<212> DNA
<213> Rattus norvegicus
<308> M17527
<400> 3380

gcggcggcg  taccgagcc  agcggtcgc  gggactcgc  ggcgcggat  gtagagcgt  60
gcgggcggg  acggccgcc  gaggcggcg  cgtatcggt  agcagacct  gcctccagc  120
tgccggagc  gaggaccta  cggggccgc  tccgggcca  cctctcccc  ctctgccag  180
cggccccgg  gccgagggc  cggcgacgc  cggccacca  gggctgcac  ctgagcgct  240
aggacaagg  ggccgtgga  cgcagcaag  tgatcgacc  caacctccg  gaggacgga  300
agaaggcag  gcgcgaggt  aagctgctg  tgctgggtg  tggtgaatc  gggaagagc  360
caattgtga  gcagatgaa  attatccac  aggctggct  ctcagagga  gagtgtaag  420
agtacaaag  agtggtcta  agcaacacc  tccagtcca  cattgccat  attagagcc  480
tggggagat  gaaaatcga  tttggagac  ctgctcgtg  ggatgatgc  cgccaactc  540
tcgtgcttg  tggggctgc  gaggaaggc  ttatgaccg  ggagctcgc  ggcgtcata  600
agagactgt  gaaggacag  ggtgtgcaa  cctgcttca  cagatcccg  gagtaccag  660
tgaacgatt  ggcggcgta  tacctgaat  acttggaca  aatagcaca  ccaaattac  720
tcccaaccc  gcaggatgt  ctcagaact  gagtgaaaa  gacgggaat  gtggaaacc  780
actttactt  caaagatct  cattttaaa  tgtttgacg  gggaggcca  agatcagag  840
ggaagaagt  gattcactg  tttgaaggc  tgactgcca  catcttctg  gtggccctg  900
gtgactatg  cctggttct  gctgaggat  aagaaatga  ccggatgca  gaaagcatg  960
agctgttcg  tagcatatg  aacaacaag  ggtttacgg  cacatccat  atccttttc  1020
tgaacaaga  ggacctctt  gaagagaag  tcaaaaaga  tcccctcac  atatgctat  1080
cagaatatg  aggctcaaa  acatatgaa  aggcggctg  gtatatcca  tgtcagttt  1140
aagacctca  taaaaggaa  gacacaaag  aaatttaca  ccacttcac  tgcgccacg  1200
atacgaaga  tgtgcagtt  gtgttcgat  ctgtaacgg  cgtcatcat  aagaataac  1260
taaaagact  tggtctctt  taagctctg  agtggggta  taaaaatgc  ttttcaaac  1320
agacgagta  ttatatatg  atctctcta  attagagtc  cccagcaac  gagaatgta  1380
tgtacagca  atgcatcct  gacctgacc  gagttctga  caaagttgt  ctgtatcgt  1440
tctttaata  aaggacctt  cgagaaggc  aaagatggt  ctggagtgt  agagggagg  1500
ttgatgttg  agctggggc  ctagtgtac  gatgatttc  gtgtaagtg  aaatatgca  1560
atgtaagat  tatttataa  ttctgattt  ccacgttat  tttatgttg  aagagtggc  1620
acttatggt  ctagtgcga  ggctttggg  aaacataac  gttaagtac  ttgtacgga  1680
tgacagatt  gttctgtgt  tggcagttt  gatcagctt  atttatgtt  gtaccccta  1740
attttaggc  ccataatta  cattaggaa  tgtcaaccc  cttaccctg  ttctatgtt  1800
acttatact  ataaaatgt  atttgtata  acgttgcac  gactatttt  gtaccatga  1860
ttgtataca  gcttttgat  catagggaa  tagtttgag  ttcattact  tatgtcaaa  1920
atgacttct  ttgcattag  tattc  1945



<210> 3381
<211> 353
<212> PRT
<213> Rattus norvegicus
<308> P10824
<400> 3381

Gly Cys Thr Leu Ser Ala Glu Asp Lys Ala Ala Val Glu Arg Ser Lys 
  1               5                  10                  15
Met Ile Asp Arg Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg Glu 
             20                  25                  30
Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile 
         35                  40                  45
Val Lys Gln Met Lys Ile Ile His Glu Ala Gly Tyr Ser Glu Glu Glu 
     50                  55                  60
Cys Lys Gln Tyr Lys Ala Val Val Tyr Ser Asn Thr Ile Gln Ser Ile 
 65                  70                  75                  80
Ile Ala Ile Ile Arg Ala Met Gly Arg Leu Lys Ile Asp Phe Gly Asp 
                 85                  90                  95
Ala Ala Arg Ala Asp Asp Ala Arg Gln Leu Phe Val Leu Ala Gly Ala 
             100                105                110
Ala Glu Glu Gly Phe Met Thr Ala Glu Leu Ala Gly Val Ile Lys Arg 
         115                120                125
Leu Trp Lys Asp Ser Gly Val Gln Ala Cys Phe Asn Arg Ser Arg Glu 
     130                135                140
Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Asp Arg 
 145                150                155                160
Ile Ala Gln Pro Asn Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg Thr 
                 165                170                175
Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys Asp 
             180                185                190
Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys 
         195                200                205
Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys Val 
     210                215                220
Ala Leu Ser Asp Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met Asn 
 225                230                235                240
Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn Lys 
                 245                250                255
Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp Leu 
             260                265                270
Phe Glu Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Tyr Pro Glu 
         275                280                285
Tyr Ala Gly Ser Asn Thr Tyr Glu Glu Ala Ala Ala Tyr Ile Gln Cys 
     290                295                300
Gln Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr Thr 
 305                310                315                320
His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe Asp 
                 325                330                335
Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly Leu 
             340                345                350
Phe 
         355



<210> 3382
<211> 1802
<212> DNA
<213> Homo sapiens
<308> AF055013
<400> 3382

gctttcggc  ccatgggct  cacgctgag  gccgaggac  aggcggcgg  ggagcggag  60
aagatgatc  accgcaacc  ccgtgagga  ggcgagaag  cggcgcgcg  ggtcaagct  120
ctgctgctc  gtgctggtg  atctggtaa  agtacaatt  tgaagcaga  gaaaattat  180
catgaagct  gttattcag  agaggagtg  aaacaatac  aagcagtgg  ctacagtaa  240
accatccag  caattattg  tatcattag  gctatgggg  ggttgaaga  agactttgg  300
gactcagcc  gggcggatg  tgcacgcca  ctctttgtg  tagctggag  tgctgaaga  360
ggctttatg  ctgcagaac  tgctggagt  ataaagaga  tgtggaaag  tagtggtgt  420
caagcctgt  tcaacagat  ccgagagta  cagcttaat  attctgcag  atactattt  480
aatgacttg  acagaatag  tcaaccaaa  tacatcccg  ctcaacaag  tgttctcag  540
actagagtg  aaactacag  aattgttga  acccatttt  ctttcaaag  tcttcattt  600
aaaatgttt  atgtgggag  tcagagatc  gagcggaag  agtggattc  ttgcttcga  660
ggagtgacg  cgatcatct  ctgtgtagc  ctgagtgac  acgacctgg  tctagctga  720
gatgaagaa  tgaaccgaa  gcatgaaag  atgaaattg  ttgacagca  atgtaacaa  780
aagtggttt  cagatacat  cattatact  tttctaaac  agaaggatc  ctttgaaga  840
aaaatcaaa  agagccctc  cactatatg  tatccagaa  atgcaggat  aaacacata  900
gaagaggca  ctgcatata  tcaatgtca  tttgaagac  tcaataaaa  aaaggacac  960
aaggaaata  acacccact  cacatgtgc  acagatact  agaatgtgc  gtttgtttt  1020
gatgctgta  cagatgtca  cataaaaaa  aatctaaaa  attgtggtc  cttttaagt  1080
ttgcagttc  tggtaaaat  cattttcaa  ccaaatgag  acttatata  ggatctctg  1140
agactagag  cttgcagca  cacagaatg  aatataagg  aaatgcatc  gggacttga  1200
caaagttgt  ctgttttgt  tttttaact  aaagtaaca  aaggacctt  cttaaatgt  1260
acagatggt  ctgcagtgt  aaactgaag  acagtgtta  agctgggct  tagtatatt  1320
atgatttct  cataagtgt  aatatgcaa  tgtatgtat  catgtattt  tgactttag  1380
tttcgacat  atttttagg  tttaagagt  gcaacttag  attttaggg  gatggcttt  1440
gaaataaca  aaatatacc  tgtactgaa  gacagacta  tactacgtt  gccagtttt  1500
aacagcttt  tttatgttc  tgtcctgta  atttttaag  acagtaatt  atattagga  1560
acattacag  ccttatcta  atcatatgt  tacttgtat  aataaaaat  ttatttgta  1620
aaacattgc  cagactatt  taataacat  atttgttct  taaatttta  gtgttttat  1680
gaaatgttc  taagatgaa  acacctgcc  ttggatcaa  tatttaaac  ttgtatgca  1740
tttgatttt  cctacttta  gaaaataaa  taatttaat  ttaaaaaaa  aaaaaaaaa  1800
aa  1802



<210> 3383
<211> 353
<212> PRT
<213> Homo sapiens
<308> P04898
<400> 3383

Gly Cys Thr Leu Ser Ala Glu Asp Lys Ala Ala Val Glu Arg Ser Lys 
  1               5                  10                  15
Met Ile Asp Arg Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg Glu 
             20                  25                  30
Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile 
         35                  40                  45
Val Lys Gln Met Lys Ile Ile His Glu Ala Gly Tyr Ser Glu Glu Glu 
     50                  55                  60
Cys Lys Gln Tyr Lys Ala Val Val Tyr Ser Asn Thr Ile Gln Ser Ile 
 65                  70                  75                  80
Ile Ala Ile Ile Arg Ala Met Gly Arg Leu Lys Ile Asp Phe Gly Asp 
                 85                  90                  95
Ser Ala Arg Ala Asp Asp Ala Arg Gln Leu Phe Val Leu Ala Gly Ala 
             100                105                110
Ala Glu Glu Gly Phe Met Thr Ala Glu Leu Ala Gly Val Ile Lys Arg 
         115                120                125
Leu Trp Lys Asp Ser Gly Val Gln Ala Cys Phe Asn Arg Ser Arg Glu 
     130                135                140
Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Asp Arg 
 145                150                155                160
Ile Ala Gln Pro Asn Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg Thr 
                 165                170                175
Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys Asp 
             180                185                190
Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys 
         195                200                205
Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys Val 
     210                215                220
Ala Leu Ser Asp Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met Asn 
 225                230                235                240
Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn Lys 
                 245                250                255
Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp Leu 
             260                265                270
Phe Glu Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Tyr Pro Glu 
         275                280                285
Tyr Ala Gly Ser Asn Thr Tyr Glu Glu Ala Ala Ala Tyr Ile Gln Cys 
     290                295                300
Gln Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr Thr 
 305                310                315                320
His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe Asp 
                 325                330                335
Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly Leu 
             340                345                350
Phe 
         355



<210> 3384
<211> 2909
<212> DNA
<213> Rattus norvegicus
<308> M18330
<400> 3384

gaattccgg  gcggcggcc  cggggatcc  gcgagcggc  cctgaacat  tacccttct  60
gccgggacc  gggaggtcc  cactggcct  cgggcccgt  ctgatcaga  tcgtgtcga  120
ctccccgtc  acgcgcatc  gggagagcc  cgccacgag  cggacccgg  cccgccggg  180
cccctggtg  ctggccctg  gtcgagagg  tggtgactg  cacccataa  ctccagctt  240
agcctcggc  tactcccct  aggggcttg  aggctgagg  ctgccctcg  acgcggctg  300
ccagcctct  cctctcttc  acactttgg  cttctcttt  gacctccta  aaaggctcc  360
tcatggcac  gttcctgcg  atctccttc  attcctatg  gctgggctc  ctgcaggcg  420
aggacgacg  aagccagcc  ttctgtgcc  tgaagatga  ggaggcact  accacagac  480
gagggaaga  tctggtaca  aagaagccc  ccatgtacc  tgagtggaa  tcaacattc  540
acgcccaca  ctatgaagg  cgtgtcatc  agatcgtgc  gatgcgggc  gctgaagac  600
ccatgtcgg  ggtgaccgt  ggcgtgtca  tgctggctg  gcgctgcaa  aagaacaac  660
gcaaggctg  gttctggct  gacctgcag  ctcaggcca  ggtgctgat  tgtgtgcag  720
atttcctgg  ggatgggga  tgcaaacag  ccatgcgta  tgaggagga  gccatgttc  780
caactatga  ccgccgtgg  gccattaaa  aggccaaga  tcactacat  aagaaccac  840
agttcatcg  caccttctt  gggcagccc  ccttctgtt  tgtgtgcaa  gagtttgtc  900
ggggcctca  caagcaagg  tacaaatgc  ggcaatgca  cgctgccat  cataagaaa  960
gcatcgaca  gattatcgg  cgctgcact  gcactgcta  caatagccg  gacaccatc  1020
tccagaaag  acgcttcaa  atcgacatg  ctcaccgat  caaggtcta  aactacatg  1080
gccccacct  ctgtgacca  tgtggcact  tgctctggg  attggtgaa  cagggatta  1140
agtgtgaag  ctgcggcat  aatgtgcac  acaaatgcc  ggagaaggt  gccaacctg  1200
gtggtatca  ccaaaagct  ttggctgag  ccttgaacc  agtgaccca  aaagcttcc  1260
ggaagccag  gacaccaga  actgtcgga  tataccagg  attcgagaa  aagacagct  1320
tctctggga  tgacatccc  gacaacaac  ggacctatg  caagatctg  gaggggagc  1380
accggtgcc  ccttgagaa  ttcaccttc  agaaagtac  tggcaaagg  agctttggc  1440
aggtactgc  tgcagaact  aagggcaag  aaaggtact  tgcaatcaa  tacctgaag  1500
aggacgtgg  gttgatcga  gatgacgtg  agtgcacca  ggtggagaa  cgggtgctg  1560
cgctcgcct  ggagaatcc  ttcctcacc  atctcatct  taccttcca  accaaggac  1620
acctcttct  tgtgatgga  ttcctcaat  ggggcgatc  gatgttcca  attcaggac  1680
aaggccgct  cgaactcta  cgggctacg  tttatgcag  tgagatcat  tgcggactg  1740
agtttctac  tggcaaagg  atcatttac  gggacctca  gctagacaa  gtaatgctg  1800
acaaggatg  ccacatcaa  attgctgac  tcgggatgt  caaagagaa  atatttggg  1860
agaaccggg  cagcacatt  tgcggcact  ctgactaca  cgcccctga  atcctgcag  1920
gcctgaagt  ctcattttc  gtggactgg  ggtcttttg  ggtcctcct  tatgagatg  1980
tcattggcc  gtccccctt  catggtgat  atgaggacg  gctctttga  tccatccgg  2040
tggacacac  acactaccc  cgctggatc  ccaaggagt  caaggacat  atggagaag  2100
tcttcgaga  ggaccctgc  aagaggctg  gagtaacag  aaacatcag  cttcacccc  2160
ttttcaaga  tatcaactg  aacctgctg  agaagcgga  ggtggagcc  ccctttaag  2220
ccaaagtga  atccccttc  gactacagc  actttgacc  agagttcct  aatgagaaa  2280
cccaacttt  cttcagtga  aagaacctc  tcgactcta  ggaccagac  gccttcaag  2340
gcttctcct  tgtgaaccc  aaatatgag  aattcctgg  atagtgagc  cccagacct  2400
cttttaatg  cccggcaga  taggcccat  tgccctggt  tgcatcctc  ctgcccatg  2460
agaagagtg  gtgactggt  attcctgct  ctgccccct  ttcctcgga  agtctggct  2520
ctgttggct  ggctcacag  acttcctct  tgaactgtt  gtgaatttg  cttcctttt  2580
ccatcggag  gaaactgta  atcctgtgt  tcattactt  aatgtagtt  ttgaaatat  2640
tattatata  atgcacata  atataatag  ctgtatata  tgctcagta  agaaagcat  2700
taggagact  gtgatgtgt  gaccttttt  taaaaaaaa  catatgtat  cgtgtgtat  2760
tatacatct  cacacgtat  catatatgt  tgtatgtat  tatgtatgt  tgtatatat  2820
accaaaaga  aagagagca  aagctacct  aaccacagg  ttgtttatg  gtgtataaa  2880
aaacactga  tggtaaaaa  ccggaattc  2909



<210> 3385
<211> 673
<212> PRT
<213> Rattus norvegicus
<308> AAA41871
<400> 3385

Met Ala Pro Phe Leu Arg Ile Ser Phe Asn Ser Tyr Glu Leu Gly Ser 
  1               5                  10                  15
Leu Gln Ala Glu Asp Asp Ala Ser Gln Pro Phe Cys Ala Val Lys Met 
             20                  25                  30
Lys Glu Ala Leu Thr Thr Asp Arg Gly Lys Thr Leu Val Gln Lys Lys 
         35                  40                  45
Pro Thr Met Tyr Pro Glu Trp Lys Ser Thr Phe Asp Ala His Ile Tyr 
     50                  55                  60
Glu Gly Arg Val Ile Gln Ile Val Leu Met Arg Ala Ala Glu Asp Pro 
 65                  70                  75                  80
Met Ser Glu Val Thr Val Gly Val Ser Val Leu Ala Glu Arg Cys Lys 
                 85                  90                  95
Lys Asn Asn Gly Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala 
             100                105                110
Lys Val Leu Met Cys Val Gln Tyr Phe Leu Glu Asp Gly Asp Cys Lys 
         115                120                125
Gln Ser Met Arg Ser Glu Glu Glu Ala Met Phe Pro Thr Met Asn Arg 
     130                135                140
Arg Gly Ala Ile Lys Gln Ala Lys Ile His Tyr Ile Lys Asn His Glu 
 145                150                155                160
Phe Ile Ala Thr Phe Phe Gly Gln Pro Thr Phe Cys Ser Val Cys Lys 
                 165                170                175
Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Lys Cys Arg Gln Cys 
             180                185                190
Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Ile Ile Gly Arg Cys 
         195                200                205
Thr Gly Thr Ala Thr Asn Ser Arg Asp Thr Ile Phe Gln Lys Glu Arg 
     210                215                220
Phe Asn Ile Asp Met Pro His Arg Phe Lys Val Tyr Asn Tyr Met Ser 
 225                230                235                240
Pro Thr Phe Cys Asp His Cys Gly Thr Leu Leu Trp Gly Leu Val Lys 
                 245                250                255
Gln Gly Leu Lys Cys Glu Asp Cys Gly Met Asn Val His His Lys Cys 
             260                265                270
Arg Glu Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Leu Ala 
         275                280                285
Glu Ala Leu Asn Gln Val Thr Gln Lys Ala Ser Arg Lys Pro Glu Thr 
     290                295                300
Pro Glu Thr Val Gly Ile Tyr Gln Gly Phe Glu Lys Lys Thr Ala Val 
 305                310                315                320
Ser Gly Asn Asp Ile Pro Asp Asn Asn Gly Thr Tyr Gly Lys Ile Trp 
                 325                330                335
Glu Gly Ser Asn Arg Cys Arg Leu Glu Asn Phe Thr Phe Gln Lys Val 
             340                345                350
Leu Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Ala Glu Leu Lys Gly 
         355                360                365
Lys Glu Arg Tyr Phe Ala Ile Lys Tyr Leu Lys Lys Asp Val Val Leu 
     370                375                380
Ile Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala 
 385                390                395                400
Leu Ala Trp Glu Asn Pro Phe Leu Thr His Leu Ile Cys Thr Phe Gln 
                 405                410                415
Thr Lys Asp His Leu Phe Phe Val Met Glu Phe Leu Asn Gly Gly Asp 
             420                425                430
Leu Met Phe His Ile Gln Asp Lys Gly Arg Phe Glu Leu Tyr Arg Ala 
         435                440                445
Thr Phe Tyr Ala Ala Glu Ile Ile Cys Gly Leu Gln Phe Leu His Gly 
     450                455                460
Lys Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp 
 465                470                475                480
Lys Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn 
                 485                490                495
Ile Phe Gly Glu Asn Arg Ala Ser Thr Phe Cys Gly Thr Pro Asp Tyr 
             500                505                510
Ile Ala Pro Glu Ile Leu Gln Gly Leu Lys Tyr Ser Phe Ser Val Asp 
         515                520                525
Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly Gln Ser 
     530                535                540
Pro Phe His Gly Asp Asp Glu Asp Glu Leu Phe Glu Ser Ile Arg Val 
 545                550                555                560
Asp Thr Pro His Tyr Pro Arg Trp Ile Thr Lys Glu Ser Lys Asp Ile 
                 565                570                575
Met Glu Lys Leu Phe Glu Arg Asp Pro Ala Lys Arg Leu Gly Val Thr 
             580                585                590
Gly Asn Ile Arg Leu His Pro Phe Phe Lys Thr Ile Asn Trp Asn Leu 
         595                600                605
Leu Glu Lys Arg Lys Val Glu Pro Pro Phe Lys Pro Lys Val Lys Ser 
     610                615                620
Pro Ser Asp Tyr Ser Asn Phe Asp Pro Glu Phe Leu Asn Glu Lys Pro 
 625                630                635                640
Gln Leu Ser Phe Ser Asp Lys Asn Leu Ile Asp Ser Met Asp Gln Thr 
                 645                650                655
Ala Phe Lys Gly Phe Ser Phe Val Asn Pro Lys Tyr Glu Gln Phe Leu 
             660                665                670
Glu 
         675



<210> 3386
<211> 2909
<212> DNA
<213> Rattus norvegicus
<308> M18330
<400> 3386

gaattccgg  gcggcggcc  cggggatcc  gcgagcggc  cctgaacat  tacccttct  60
gccgggacc  gggaggtcc  cactggcct  cgggcccgt  ctgatcaga  tcgtgtcga  120
ctccccgtc  acgcgcatc  gggagagcc  cgccacgag  cggacccgg  cccgccggg  180
cccctggtg  ctggccctg  gtcgagagg  tggtgactg  cacccataa  ctccagctt  240
agcctcggc  tactcccct  aggggcttg  aggctgagg  ctgccctcg  acgcggctg  300
ccagcctct  cctctcttc  acactttgg  cttctcttt  gacctccta  aaaggctcc  360
tcatggcac  gttcctgcg  atctccttc  attcctatg  gctgggctc  ctgcaggcg  420
aggacgacg  aagccagcc  ttctgtgcc  tgaagatga  ggaggcact  accacagac  480
gagggaaga  tctggtaca  aagaagccc  ccatgtacc  tgagtggaa  tcaacattc  540
acgcccaca  ctatgaagg  cgtgtcatc  agatcgtgc  gatgcgggc  gctgaagac  600
ccatgtcgg  ggtgaccgt  ggcgtgtca  tgctggctg  gcgctgcaa  aagaacaac  660
gcaaggctg  gttctggct  gacctgcag  ctcaggcca  ggtgctgat  tgtgtgcag  720
atttcctgg  ggatgggga  tgcaaacag  ccatgcgta  tgaggagga  gccatgttc  780
caactatga  ccgccgtgg  gccattaaa  aggccaaga  tcactacat  aagaaccac  840
agttcatcg  caccttctt  gggcagccc  ccttctgtt  tgtgtgcaa  gagtttgtc  900
ggggcctca  caagcaagg  tacaaatgc  ggcaatgca  cgctgccat  cataagaaa  960
gcatcgaca  gattatcgg  cgctgcact  gcactgcta  caatagccg  gacaccatc  1020
tccagaaag  acgcttcaa  atcgacatg  ctcaccgat  caaggtcta  aactacatg  1080
gccccacct  ctgtgacca  tgtggcact  tgctctggg  attggtgaa  cagggatta  1140
agtgtgaag  ctgcggcat  aatgtgcac  acaaatgcc  ggagaaggt  gccaacctg  1200
gtggtatca  ccaaaagct  ttggctgag  ccttgaacc  agtgaccca  aaagcttcc  1260
ggaagccag  gacaccaga  actgtcgga  tataccagg  attcgagaa  aagacagct  1320
tctctggga  tgacatccc  gacaacaac  ggacctatg  caagatctg  gaggggagc  1380
accggtgcc  ccttgagaa  ttcaccttc  agaaagtac  tggcaaagg  agctttggc  1440
aggtactgc  tgcagaact  aagggcaag  aaaggtact  tgcaatcaa  tacctgaag  1500
aggacgtgg  gttgatcga  gatgacgtg  agtgcacca  ggtggagaa  cgggtgctg  1560
cgctcgcct  ggagaatcc  ttcctcacc  atctcatct  taccttcca  accaaggac  1620
acctcttct  tgtgatgga  ttcctcaat  ggggcgatc  gatgttcca  attcaggac  1680
aaggccgct  cgaactcta  cgggctacg  tttatgcag  tgagatcat  tgcggactg  1740
agtttctac  tggcaaagg  atcatttac  gggacctca  gctagacaa  gtaatgctg  1800
acaaggatg  ccacatcaa  attgctgac  tcgggatgt  caaagagaa  atatttggg  1860
agaaccggg  cagcacatt  tgcggcact  ctgactaca  cgcccctga  atcctgcag  1920
gcctgaagt  ctcattttc  gtggactgg  ggtcttttg  ggtcctcct  tatgagatg  1980
tcattggcc  gtccccctt  catggtgat  atgaggacg  gctctttga  tccatccgg  2040
tggacacac  acactaccc  cgctggatc  ccaaggagt  caaggacat  atggagaag  2100
tcttcgaga  ggaccctgc  aagaggctg  gagtaacag  aaacatcag  cttcacccc  2160
ttttcaaga  tatcaactg  aacctgctg  agaagcgga  ggtggagcc  ccctttaag  2220
ccaaagtga  atccccttc  gactacagc  actttgacc  agagttcct  aatgagaaa  2280
cccaacttt  cttcagtga  aagaacctc  tcgactcta  ggaccagac  gccttcaag  2340
gcttctcct  tgtgaaccc  aaatatgag  aattcctgg  atagtgagc  cccagacct  2400
cttttaatg  cccggcaga  taggcccat  tgccctggt  tgcatcctc  ctgcccatg  2460
agaagagtg  gtgactggt  attcctgct  ctgccccct  ttcctcgga  agtctggct  2520
ctgttggct  ggctcacag  acttcctct  tgaactgtt  gtgaatttg  cttcctttt  2580
ccatcggag  gaaactgta  atcctgtgt  tcattactt  aatgtagtt  ttgaaatat  2640
tattatata  atgcacata  atataatag  ctgtatata  tgctcagta  agaaagcat  2700
taggagact  gtgatgtgt  gaccttttt  taaaaaaaa  catatgtat  cgtgtgtat  2760
tatacatct  cacacgtat  catatatgt  tgtatgtat  tatgtatgt  tgtatatat  2820
accaaaaga  aagagagca  aagctacct  aaccacagg  ttgtttatg  gtgtataaa  2880
aaacactga  tggtaaaaa  ccggaattc  2909



<210> 3387
<211> 673
<212> PRT
<213> Rattus norvegicus
<308> AAA41871
<400> 3387

Met Ala Pro Phe Leu Arg Ile Ser Phe Asn Ser Tyr Glu Leu Gly Ser 
  1               5                  10                  15
Leu Gln Ala Glu Asp Asp Ala Ser Gln Pro Phe Cys Ala Val Lys Met 
             20                  25                  30
Lys Glu Ala Leu Thr Thr Asp Arg Gly Lys Thr Leu Val Gln Lys Lys 
         35                  40                  45
Pro Thr Met Tyr Pro Glu Trp Lys Ser Thr Phe Asp Ala His Ile Tyr 
     50                  55                  60
Glu Gly Arg Val Ile Gln Ile Val Leu Met Arg Ala Ala Glu Asp Pro 
 65                  70                  75                  80
Met Ser Glu Val Thr Val Gly Val Ser Val Leu Ala Glu Arg Cys Lys 
                 85                  90                  95
Lys Asn Asn Gly Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala 
             100                105                110
Lys Val Leu Met Cys Val Gln Tyr Phe Leu Glu Asp Gly Asp Cys Lys 
         115                120                125
Gln Ser Met Arg Ser Glu Glu Glu Ala Met Phe Pro Thr Met Asn Arg 
     130                135                140
Arg Gly Ala Ile Lys Gln Ala Lys Ile His Tyr Ile Lys Asn His Glu 
 145                150                155                160
Phe Ile Ala Thr Phe Phe Gly Gln Pro Thr Phe Cys Ser Val Cys Lys 
                 165                170                175
Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Lys Cys Arg Gln Cys 
             180                185                190
Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Ile Ile Gly Arg Cys 
         195                200                205
Thr Gly Thr Ala Thr Asn Ser Arg Asp Thr Ile Phe Gln Lys Glu Arg 
     210                215                220
Phe Asn Ile Asp Met Pro His Arg Phe Lys Val Tyr Asn Tyr Met Ser 
 225                230                235                240
Pro Thr Phe Cys Asp His Cys Gly Thr Leu Leu Trp Gly Leu Val Lys 
                 245                250                255
Gln Gly Leu Lys Cys Glu Asp Cys Gly Met Asn Val His His Lys Cys 
             260                265                270
Arg Glu Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Leu Ala 
         275                280                285
Glu Ala Leu Asn Gln Val Thr Gln Lys Ala Ser Arg Lys Pro Glu Thr 
     290                295                300
Pro Glu Thr Val Gly Ile Tyr Gln Gly Phe Glu Lys Lys Thr Ala Val 
 305                310                315                320
Ser Gly Asn Asp Ile Pro Asp Asn Asn Gly Thr Tyr Gly Lys Ile Trp 
                 325                330                335
Glu Gly Ser Asn Arg Cys Arg Leu Glu Asn Phe Thr Phe Gln Lys Val 
             340                345                350
Leu Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Ala Glu Leu Lys Gly 
         355                360                365
Lys Glu Arg Tyr Phe Ala Ile Lys Tyr Leu Lys Lys Asp Val Val Leu 
     370                375                380
Ile Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala 
 385                390                395                400
Leu Ala Trp Glu Asn Pro Phe Leu Thr His Leu Ile Cys Thr Phe Gln 
                 405                410                415
Thr Lys Asp His Leu Phe Phe Val Met Glu Phe Leu Asn Gly Gly Asp 
             420                425                430
Leu Met Phe His Ile Gln Asp Lys Gly Arg Phe Glu Leu Tyr Arg Ala 
         435                440                445
Thr Phe Tyr Ala Ala Glu Ile Ile Cys Gly Leu Gln Phe Leu His Gly 
     450                455                460
Lys Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp 
 465                470                475                480
Lys Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn 
                 485                490                495
Ile Phe Gly Glu Asn Arg Ala Ser Thr Phe Cys Gly Thr Pro Asp Tyr 
             500                505                510
Ile Ala Pro Glu Ile Leu Gln Gly Leu Lys Tyr Ser Phe Ser Val Asp 
         515                520                525
Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly Gln Ser 
     530                535                540
Pro Phe His Gly Asp Asp Glu Asp Glu Leu Phe Glu Ser Ile Arg Val 
 545                550                555                560
Asp Thr Pro His Tyr Pro Arg Trp Ile Thr Lys Glu Ser Lys Asp Ile 
                 565                570                575
Met Glu Lys Leu Phe Glu Arg Asp Pro Ala Lys Arg Leu Gly Val Thr 
             580                585                590
Gly Asn Ile Arg Leu His Pro Phe Phe Lys Thr Ile Asn Trp Asn Leu 
         595                600                605
Leu Glu Lys Arg Lys Val Glu Pro Pro Phe Lys Pro Lys Val Lys Ser 
     610                615                620
Pro Ser Asp Tyr Ser Asn Phe Asp Pro Glu Phe Leu Asn Glu Lys Pro 
 625                630                635                640
Gln Leu Ser Phe Ser Asp Lys Asn Leu Ile Asp Ser Met Asp Gln Thr 
                 645                650                655
Ala Phe Lys Gly Phe Ser Phe Val Asn Pro Lys Tyr Glu Gln Phe Leu 
             660                665                670
Glu 
         675



<210> 3388
<211> 2704
<212> DNA
<213> Rattus norvegicus
<308> M18331
<400> 3388

gaattccgg  atccggcga  gaaatacat  cactcgctg  gaatcgccg  cgccaggac  60
cagcgccac  aggtgtagc  agtgagtgg  gtggggcaa  aggggaccc  ggagtcccc  120
caggctccc  gcgcgcctg  tcctgctct  caatcctgc  ctcggggcg  acggagtga  180
ccccgcccc  accatggta  tgttcaatg  ccttcttaa  atcaaaatc  gcgaggccg  240
gagcttgaa  cccacagcc  ggtcgctgc  ccatgcggt  ggaccccgg  cccagacgt  300
ccttctgga  ccctacatt  cccttaacg  ggacgactc  cgcatcggc  aaacagcca  360
caagcagaa  accaacagt  cggcctggc  cgatgagtt  gtcactgat  tgtgcaatg  420
gcgcaagat  gagctggct  tctttcacg  tgctcctat  ggctacgac  acttcgtgg  480
caactgcac  atccagttc  aggagctgc  gcagaatgg  agccgtcac  tcgaggact  540
gattgatct  gagccagaa  gaaaagtct  cgtgatcat  gatctctcg  gatcatcgg  600
cgaagcccc  aaagacaat  aagaacgag  gtttaggga  cggatgcgg  caaggaagc  660
ccaaggggc  gtcaggcgc  gggtccacc  ggtcaatgg  cacaagttc  tggccacct  720
cttgcggca  cccacctac  gctcccact  tagggattt  atctggggt  tcataggaa  780
acagggata  caatgtcaa  tttgtacct  cgtcgtcca  aaacgatgc  atgagctca  840
tattacgaa  tgcgctggg  taaagaaac  ggaaacccc  gacgaggtg  gctcccaac  900
cttcagcgt  aacatgccc  acaagttcg  gatccacaa  tacaaggtc  ccacgttct  960
tgaccactg  ggctccctg  tctggggcc  cttgcggca  ggcctgcag  gtaaagtct  1020
caaaatgaa  gttcaccgt  gatgcgaga  caacgtggc  cccaattgt  gggtggacg  1080
cagaggaat  gccaaggtg  tggccgatc  tggcgttac  ccagacaaa  tcaccaaca  1140
tggccagag  aggaaaaag  tcgctgctg  tgctgagtc  ccacagccg  cttctggaa  1200
ctccccatc  gaagacgac  gatccaagt  agcgcccac  tccccttgt  accaggaac  1260
aaaagaact  gaaaacaac  tccggaagg  cttgtcatt  gacaaccga  gagaggagc  1320
ccgagcctc  tcgtctact  atggccagc  ggcaagccc  ggcgagaac  gtgaagtcc  1380
gcaaggcca  gccaagcgc  tgggcctgg  tgagttcaa  ttcatcaag  tgttaggca  1440
aggcagctt  ggcaaggtc  tgctggccg  gctcaaggg  aaggatgaa  tctatgctg  1500
gaaggtctt  aagaaggac  tcatcctgc  ggatgacga  gtggactgc  cgatgacag  1560
gaagaggat  ttggctctg  cgcggaaac  cccttatct  acccaactc  attgctgct  1620
ccagaccaa  gaccggctc  tcttcgtca  ggaatatgt  aacggtgga  acctcatgt  1680
ccagattca  cggtcccga  aattcgatg  gcctcgttc  gggttctat  ctgccgagg  1740
cacatctgc  ctcatgttt  tccaccaac  tggagtgat  tacagggat  tgaaactgg  1800
caacatcct  ctagatgca  aaggtcact  caagctggc  gactttggg  tgtgcaagg  1860
agggattct  aatggcgtg  caactacca  cttctgtgg  actcctgac  acatagctc  1920
agagatcct  caggagttg  agtacggcc  ctcagtgga  tggtgggcc  tgggcgtgc  1980
gatgtacga  atgatggcc  ggcagcccc  ctttgaagc  gacaacgag  acgacttgt  2040
tgaatccat  cttcacgat  acgttctct  ccctgtctg  cttagcaag  aggctgtca  2100
catcctgaa  gctttcatg  ccaagaacc  gcacaagcg  ctgggctgc  tggcagcac  2160
gaacgggga  gatgccatc  agcaacatc  attcttcaa  gagattgac  gggtactgc  2220
ggagcagaa  aaaatgaag  cccccttca  gccgagaat  aaaaccaag  gagatgtca  2280
taactttga  caagacttt  cccgggaag  gccaatact  acacttgtg  atgaagcaa  2340
cgtgaagca  atcaaccag  aagaattca  aggcttctc  tactttggt  aagacctga  2400
gccctgaga  actgcttca  atggagtta  ctcactgca  ggagggtgt  gagacaatc  2460
cgtgttgca  aggctcaga  tgtctcgaa  tattcgtcc  ccccagagc  ccagtccca  2520
atctgctct  ttatttatt  catcccctc  tcccaggcc  tgtccttcc  caccctccc  2580
gtgaccaga  ggccctctt  ggtccagac  caccaagat  acagatttg  actgcgtct  2640
ctctgtgtg  agtgctagg  ctggagtag  cgtccaccc  caaccctga  gcagcccgg  2700
attc  2704



<210> 3389
<211> 737
<212> PRT
<213> Rattus norvegicus
<308> AAA41872
<400> 3389

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
  1               5                  10                  15
Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
             20                  25                  30
Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
         35                  40                  45
Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
     50                  55                  60
Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
 65                  70                  75                  80
Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                 85                  90                  95
Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
             100                105                110
Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Lys Val Tyr Val Ile 
         115                120                125
Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
     130                135                140
Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
 145                150                155                160
Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                 165                170                175
Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
             180                185                190
Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
         195                200                205
His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
     210                215                220
Lys Gln Glu Thr Pro Asp Glu Val Gly Ser Gln Arg Phe Ser Val Asn 
 225                230                235                240
Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                 245                250                255
Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
             260                265                270
Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
         275                280                285
Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
     290                295                300
Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
 305                310                315                320
Lys Lys Leu Ala Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Asn 
                 325                330                335
Ser Pro Ser Glu Asp Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
             340                345                350
Asp Gln Glu Leu Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
         355                360                365
Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ser Ser Ser Thr Asp Gly 
     370                375                380
Gln Leu Ala Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
 385                390                395                400
Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                 405                410                415
Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
             420                425                430
Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
         435                440                445
Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
     450                455                460
Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
 465                470                475                480
Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                 485                490                495
Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Gly Phe Tyr 
             500                505                510
Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
         515                520                525
Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
     530                535                540
His Ser Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
 545                550                555                560
Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                 565                570                575
Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
             580                585                590
Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
         595                600                605
Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
     610                615                620
Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
 625                630                635                640
Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ala Gln 
                 645                650                655
Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
             660                665                670
Trp Val Leu Leu Glu Gln Lys Lys Met Lys Pro Pro Phe Lys Pro Arg 
         675                680                685
Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
     690                695                700
Glu Glu Pro Ile Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
 705                710                715                720
Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                 725                730                735
Pro 
             740



<210> 3390
<211> 2244
<212> DNA
<213> Homo sapiens
<308> NM_005400
<400> 3390

ctccccgcc  cgaccatgg  agtgttcaa  ggccttctt  agatcaaaa  ctgcgaggc  60
gtgagcttg  agcccacag  ctggtcgct  cgccatgcg  tgggacccc  gccgcagac  120
ttccttctc  acccctaca  tgccctcaa  gtggacgac  cgcgcatcg  ccaaacggc  180
accaagcag  agaccaaca  cccggcctg  cacgacgag  tcgtcaccg  tgtgtgcaa  240
ggacgcaag  tcgagctgg  tgtctttca  gatgccccc  taggctacg  cgacttcgt  300
gccaactgc  ccatccagt  tgaggagct  ctgcagaac  ggagccgcc  cttcgagga  360
tggattgat  tggagccag  aggaagagt  tatgtgatc  tcgatctct  agggtcgtc  420
ggtgaagcc  ctaaagaca  tgaagagcg  gtgttcagg  aacgcatgc  gccgaggaa  480
cggcagggg  ccgtcaggc  cagggtcca  caggtcaac  gccacaagt  catggccac  540
tatcttcgg  agcccacct  ctgctccca  tgcagagac  tcatctggg  tgtcatagg  600
aagcaggga  accagtgtc  agtctgcac  tgcgtggtc  acaagcggt  ccacgagct  660
ataatcaca  agtgtgctg  gttaaagaa  caggagacc  ccgaccagg  gggctccca  720
cggttcagc  tcaacatgc  ccacaagtt  ggtatccac  actacaagg  ccctacctt  780
tgcgatcac  gtgggtccc  gctctgggg  ctcttgcgg  agggtttgc  gtgtaaagt  840
tgcaaaatg  atgttcacc  tcgatgtga  accaacgtg  ctcccaact  tggagtgga  900
gccagagga  tcgccaaag  actggccga  ctgggcgtt  ccccagaca  aatcaccaa  960
agcggccag  gaaggaaaa  gctcattgc  ggtgccgag  ccccgcagc  tgcttctgg  1020
agctcacca  ctgaggaag  tcgatccaa  tcagcaccc  cctcccctt  tgaccagga  1080
ataaaagaa  ttgagaaca  cattcggaa  gccttgtca  ttgacaacc  aggagagga  1140
caccgggca  catcgtctc  tgatggcca  ctgatgagc  ccggtgaga  tggcgaagt  1200
cggcaaggc  aggccaagc  cctgggcct  gatgagttc  acttcatca  ggtgttggg  1260
aaaggcagc  ttggcaagg  catgttggc  gaactcaag  gcaaagatg  agtatatgc  1320
gtgaaggtc  taaagaagg  cgtcatcct  caggatgat  acgtggact  cacaatgac  1380
gagaagagg  ttttggctc  ggcacggaa  cacccgtac  ttacccaac  ctactgctg  1440
ttccagacc  aggaccgcc  ctttttcgt  atggaatat  taaatggtg  agacctcat  1500
tttcagatt  agcgctccc  aaaattcga  gagcctcgt  cacggttct  tgctgcaga  1560
gtcacatcg  ccctcatgt  cctccatca  catggagtc  tctacaggg  tttgaaact  1620
gacaacatc  ttctggatg  agaaggtca  tgcaagctg  ctgacttcg  gatgtgcaa  1680
gaagggatt  tgaatggtg  gacgaccac  acgttctgt  ggactcctg  ctacatagc  1740
cctgagatc  tgcaggagt  ggagtatgg  ccctccgtg  actggtggg  cctgggggt  1800
ctgatgtac  agatgatgg  tggacagcc  ccctttgag  ccgacaatg  ggacgacct  1860
tttgagtcc  tcctccatg  cgacgtgct  tacccagtc  ggctcagca  ggaggctgt  1920
agcatcttg  aagctttca  gacgaagaa  ccccacaag  gcctgggct  tgtggcatc  1980
cagaatggc  aggacgcca  caagcagca  ccattcttc  aagagattg  ctgggtgct  2040
ctggagcag  agaagatca  gccaccctt  aaaccacgc  ttaaaacca  aagagacgt  2100
aataatttt  accaagact  tacccggga  gagccggta  tcacccttg  ggacgaagc  2160
attgtaaag  agatcaacc  ggaggaatt  aaaggtttc  cctactttg  tgaagacct  2220
atgccctga  agcccactg  agtt  2244



<210> 3391
<211> 737
<212> PRT
<213> Homo sapiens
<308> Q02156
<400> 3391

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
  1               5                  10                  15
Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
             20                  25                  30
Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
         35                  40                  45
Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
     50                  55                  60
Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
 65                  70                  75                  80
Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                 85                  90                  95
Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
             100                105                110
Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Arg Val Tyr Val Ile 
         115                120                125
Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
     130                135                140
Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
 145                150                155                160
Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                 165                170                175
Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
             180                185                190
Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
         195                200                205
His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
     210                215                220
Lys Gln Glu Thr Pro Asp Gln Val Gly Ser Gln Arg Phe Ser Val Asn 
 225                230                235                240
Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                 245                250                255
Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
             260                265                270
Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
         275                280                285
Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
     290                295                300
Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
 305                310                315                320
Lys Lys Leu Ile Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Ser 
                 325                330                335
Ser Pro Ser Glu Glu Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
             340                345                350
Asp Gln Glu Ile Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
         355                360                365
Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ala Ser Ser Pro Asp Gly 
     370                375                380
Gln Leu Met Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
 385                390                395                400
Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                 405                410                415
Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
             420                425                430
Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
         435                440                445
Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
     450                455                460
Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
 465                470                475                480
Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                 485                490                495
Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Arg Phe Tyr 
             500                505                510
Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
         515                520                525
Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
     530                535                540
His Cys Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
 545                550                555                560
Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                 565                570                575
Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
             580                585                590
Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
         595                600                605
Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
     610                615                620
Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
 625                630                635                640
Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ser Gln 
                 645                650                655
Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
             660                665                670
Trp Val Leu Leu Glu Gln Lys Lys Ile Lys Pro Pro Phe Lys Pro Arg 
         675                680                685
Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
     690                695                700
Glu Glu Pro Val Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
 705                710                715                720
Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                 725                730                735
Pro 
             740



<210> 3392
<211> 2704
<212> DNA
<213> Rattus norvegicus
<308> M18331
<400> 3392

gaattccgg  atccggcga  gaaatacat  cactcgctg  gaatcgccg  cgccaggac  60
cagcgccac  aggtgtagc  agtgagtgg  gtggggcaa  aggggaccc  ggagtcccc  120
caggctccc  gcgcgcctg  tcctgctct  caatcctgc  ctcggggcg  acggagtga  180
ccccgcccc  accatggta  tgttcaatg  ccttcttaa  atcaaaatc  gcgaggccg  240
gagcttgaa  cccacagcc  ggtcgctgc  ccatgcggt  ggaccccgg  cccagacgt  300
ccttctgga  ccctacatt  cccttaacg  ggacgactc  cgcatcggc  aaacagcca  360
caagcagaa  accaacagt  cggcctggc  cgatgagtt  gtcactgat  tgtgcaatg  420
gcgcaagat  gagctggct  tctttcacg  tgctcctat  ggctacgac  acttcgtgg  480
caactgcac  atccagttc  aggagctgc  gcagaatgg  agccgtcac  tcgaggact  540
gattgatct  gagccagaa  gaaaagtct  cgtgatcat  gatctctcg  gatcatcgg  600
cgaagcccc  aaagacaat  aagaacgag  gtttaggga  cggatgcgg  caaggaagc  660
ccaaggggc  gtcaggcgc  gggtccacc  ggtcaatgg  cacaagttc  tggccacct  720
cttgcggca  cccacctac  gctcccact  tagggattt  atctggggt  tcataggaa  780
acagggata  caatgtcaa  tttgtacct  cgtcgtcca  aaacgatgc  atgagctca  840
tattacgaa  tgcgctggg  taaagaaac  ggaaacccc  gacgaggtg  gctcccaac  900
cttcagcgt  aacatgccc  acaagttcg  gatccacaa  tacaaggtc  ccacgttct  960
tgaccactg  ggctccctg  tctggggcc  cttgcggca  ggcctgcag  gtaaagtct  1020
caaaatgaa  gttcaccgt  gatgcgaga  caacgtggc  cccaattgt  gggtggacg  1080
cagaggaat  gccaaggtg  tggccgatc  tggcgttac  ccagacaaa  tcaccaaca  1140
tggccagag  aggaaaaag  tcgctgctg  tgctgagtc  ccacagccg  cttctggaa  1200
ctccccatc  gaagacgac  gatccaagt  agcgcccac  tccccttgt  accaggaac  1260
aaaagaact  gaaaacaac  tccggaagg  cttgtcatt  gacaaccga  gagaggagc  1320
ccgagcctc  tcgtctact  atggccagc  ggcaagccc  ggcgagaac  gtgaagtcc  1380
gcaaggcca  gccaagcgc  tgggcctgg  tgagttcaa  ttcatcaag  tgttaggca  1440
aggcagctt  ggcaaggtc  tgctggccg  gctcaaggg  aaggatgaa  tctatgctg  1500
gaaggtctt  aagaaggac  tcatcctgc  ggatgacga  gtggactgc  cgatgacag  1560
gaagaggat  ttggctctg  cgcggaaac  cccttatct  acccaactc  attgctgct  1620
ccagaccaa  gaccggctc  tcttcgtca  ggaatatgt  aacggtgga  acctcatgt  1680
ccagattca  cggtcccga  aattcgatg  gcctcgttc  gggttctat  ctgccgagg  1740
cacatctgc  ctcatgttt  tccaccaac  tggagtgat  tacagggat  tgaaactgg  1800
caacatcct  ctagatgca  aaggtcact  caagctggc  gactttggg  tgtgcaagg  1860
agggattct  aatggcgtg  caactacca  cttctgtgg  actcctgac  acatagctc  1920
agagatcct  caggagttg  agtacggcc  ctcagtgga  tggtgggcc  tgggcgtgc  1980
gatgtacga  atgatggcc  ggcagcccc  ctttgaagc  gacaacgag  acgacttgt  2040
tgaatccat  cttcacgat  acgttctct  ccctgtctg  cttagcaag  aggctgtca  2100
catcctgaa  gctttcatg  ccaagaacc  gcacaagcg  ctgggctgc  tggcagcac  2160
gaacgggga  gatgccatc  agcaacatc  attcttcaa  gagattgac  gggtactgc  2220
ggagcagaa  aaaatgaag  cccccttca  gccgagaat  aaaaccaag  gagatgtca  2280
taactttga  caagacttt  cccgggaag  gccaatact  acacttgtg  atgaagcaa  2340
cgtgaagca  atcaaccag  aagaattca  aggcttctc  tactttggt  aagacctga  2400
gccctgaga  actgcttca  atggagtta  ctcactgca  ggagggtgt  gagacaatc  2460
cgtgttgca  aggctcaga  tgtctcgaa  tattcgtcc  ccccagagc  ccagtccca  2520
atctgctct  ttatttatt  catcccctc  tcccaggcc  tgtccttcc  caccctccc  2580
gtgaccaga  ggccctctt  ggtccagac  caccaagat  acagatttg  actgcgtct  2640
ctctgtgtg  agtgctagg  ctggagtag  cgtccaccc  caaccctga  gcagcccgg  2700
attc  2704



<210> 3393
<211> 737
<212> PRT
<213> Rattus norvegicus
<308> AAA41872
<400> 3393

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
  1               5                  10                  15
Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
             20                  25                  30
Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
         35                  40                  45
Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
     50                  55                  60
Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
 65                  70                  75                  80
Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                 85                  90                  95
Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
             100                105                110
Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Lys Val Tyr Val Ile 
         115                120                125
Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
     130                135                140
Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
 145                150                155                160
Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                 165                170                175
Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
             180                185                190
Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
         195                200                205
His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
     210                215                220
Lys Gln Glu Thr Pro Asp Glu Val Gly Ser Gln Arg Phe Ser Val Asn 
 225                230                235                240
Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                 245                250                255
Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
             260                265                270
Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
         275                280                285
Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
     290                295                300
Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
 305                310                315                320
Lys Lys Leu Ala Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Asn 
                 325                330                335
Ser Pro Ser Glu Asp Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
             340                345                350
Asp Gln Glu Leu Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
         355                360                365
Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ser Ser Ser Thr Asp Gly 
     370                375                380
Gln Leu Ala Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
 385                390                395                400
Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                 405                410                415
Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
             420                425                430
Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
         435                440                445
Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
     450                455                460
Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
 465                470                475                480
Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                 485                490                495
Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Gly Phe Tyr 
             500                505                510
Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
         515                520                525
Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
     530                535                540
His Ser Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
 545                550                555                560
Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                 565                570                575
Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
             580                585                590
Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
         595                600                605
Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
     610                615                620
Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
 625                630                635                640
Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ala Gln 
                 645                650                655
Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
             660                665                670
Trp Val Leu Leu Glu Gln Lys Lys Met Lys Pro Pro Phe Lys Pro Arg 
         675                680                685
Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
     690                695                700
Glu Glu Pro Ile Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
 705                710                715                720
Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                 725                730                735
Pro 
             740



<210> 3394
<211> 2244
<212> DNA
<213> Homo sapiens
<308> NM_005400
<400> 3394

ctccccgcc  cgaccatgg  agtgttcaa  ggccttctt  agatcaaaa  ctgcgaggc  60
gtgagcttg  agcccacag  ctggtcgct  cgccatgcg  tgggacccc  gccgcagac  120
ttccttctc  acccctaca  tgccctcaa  gtggacgac  cgcgcatcg  ccaaacggc  180
accaagcag  agaccaaca  cccggcctg  cacgacgag  tcgtcaccg  tgtgtgcaa  240
ggacgcaag  tcgagctgg  tgtctttca  gatgccccc  taggctacg  cgacttcgt  300
gccaactgc  ccatccagt  tgaggagct  ctgcagaac  ggagccgcc  cttcgagga  360
tggattgat  tggagccag  aggaagagt  tatgtgatc  tcgatctct  agggtcgtc  420
ggtgaagcc  ctaaagaca  tgaagagcg  gtgttcagg  aacgcatgc  gccgaggaa  480
cggcagggg  ccgtcaggc  cagggtcca  caggtcaac  gccacaagt  catggccac  540
tatcttcgg  agcccacct  ctgctccca  tgcagagac  tcatctggg  tgtcatagg  600
aagcaggga  accagtgtc  agtctgcac  tgcgtggtc  acaagcggt  ccacgagct  660
ataatcaca  agtgtgctg  gttaaagaa  caggagacc  ccgaccagg  gggctccca  720
cggttcagc  tcaacatgc  ccacaagtt  ggtatccac  actacaagg  ccctacctt  780
tgcgatcac  gtgggtccc  gctctgggg  ctcttgcgg  agggtttgc  gtgtaaagt  840
tgcaaaatg  atgttcacc  tcgatgtga  accaacgtg  ctcccaact  tggagtgga  900
gccagagga  tcgccaaag  actggccga  ctgggcgtt  ccccagaca  aatcaccaa  960
agcggccag  gaaggaaaa  gctcattgc  ggtgccgag  ccccgcagc  tgcttctgg  1020
agctcacca  ctgaggaag  tcgatccaa  tcagcaccc  cctcccctt  tgaccagga  1080
ataaaagaa  ttgagaaca  cattcggaa  gccttgtca  ttgacaacc  aggagagga  1140
caccgggca  catcgtctc  tgatggcca  ctgatgagc  ccggtgaga  tggcgaagt  1200
cggcaaggc  aggccaagc  cctgggcct  gatgagttc  acttcatca  ggtgttggg  1260
aaaggcagc  ttggcaagg  catgttggc  gaactcaag  gcaaagatg  agtatatgc  1320
gtgaaggtc  taaagaagg  cgtcatcct  caggatgat  acgtggact  cacaatgac  1380
gagaagagg  ttttggctc  ggcacggaa  cacccgtac  ttacccaac  ctactgctg  1440
ttccagacc  aggaccgcc  ctttttcgt  atggaatat  taaatggtg  agacctcat  1500
tttcagatt  agcgctccc  aaaattcga  gagcctcgt  cacggttct  tgctgcaga  1560
gtcacatcg  ccctcatgt  cctccatca  catggagtc  tctacaggg  tttgaaact  1620
gacaacatc  ttctggatg  agaaggtca  tgcaagctg  ctgacttcg  gatgtgcaa  1680
gaagggatt  tgaatggtg  gacgaccac  acgttctgt  ggactcctg  ctacatagc  1740
cctgagatc  tgcaggagt  ggagtatgg  ccctccgtg  actggtggg  cctgggggt  1800
ctgatgtac  agatgatgg  tggacagcc  ccctttgag  ccgacaatg  ggacgacct  1860
tttgagtcc  tcctccatg  cgacgtgct  tacccagtc  ggctcagca  ggaggctgt  1920
agcatcttg  aagctttca  gacgaagaa  ccccacaag  gcctgggct  tgtggcatc  1980
cagaatggc  aggacgcca  caagcagca  ccattcttc  aagagattg  ctgggtgct  2040
ctggagcag  agaagatca  gccaccctt  aaaccacgc  ttaaaacca  aagagacgt  2100
aataatttt  accaagact  tacccggga  gagccggta  tcacccttg  ggacgaagc  2160
attgtaaag  agatcaacc  ggaggaatt  aaaggtttc  cctactttg  tgaagacct  2220
atgccctga  agcccactg  agtt  2244



<210> 3395
<211> 737
<212> PRT
<213> Homo sapiens
<308> Q02156
<400> 3395

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
  1               5                  10                  15
Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
             20                  25                  30
Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
         35                  40                  45
Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
     50                  55                  60
Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
 65                  70                  75                  80
Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                 85                  90                  95
Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
             100                105                110
Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Arg Val Tyr Val Ile 
         115                120                125
Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
     130                135                140
Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
 145                150                155                160
Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                 165                170                175
Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
             180                185                190
Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
         195                200                205
His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
     210                215                220
Lys Gln Glu Thr Pro Asp Gln Val Gly Ser Gln Arg Phe Ser Val Asn 
 225                230                235                240
Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                 245                250                255
Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
             260                265                270
Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
         275                280                285
Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
     290                295                300
Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
 305                310                315                320
Lys Lys Leu Ile Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Ser 
                 325                330                335
Ser Pro Ser Glu Glu Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
             340                345                350
Asp Gln Glu Ile Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
         355                360                365
Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ala Ser Ser Pro Asp Gly 
     370                375                380
Gln Leu Met Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
 385                390                395                400
Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                 405                410                415
Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
             420                425                430
Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
         435                440                445
Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
     450                455                460
Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
 465                470                475                480
Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                 485                490                495
Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Arg Phe Tyr 
             500                505                510
Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
         515                520                525
Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
     530                535                540
His Cys Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
 545                550                555                560
Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                 565                570                575
Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
             580                585                590
Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
         595                600                605
Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
     610                615                620
Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
 625                630                635                640
Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ser Gln 
                 645                650                655
Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
             660                665                670
Trp Val Leu Leu Glu Gln Lys Lys Ile Lys Pro Pro Phe Lys Pro Arg 
         675                680                685
Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
     690                695                700
Glu Glu Pro Val Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
 705                710                715                720
Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                 725                730                735
Pro 
             740



<210> 3396
<211> 2704
<212> DNA
<213> Rattus norvegicus
<308> M18331
<400> 3396

gaattccgg  atccggcga  gaaatacat  cactcgctg  gaatcgccg  cgccaggac  60
cagcgccac  aggtgtagc  agtgagtgg  gtggggcaa  aggggaccc  ggagtcccc  120
caggctccc  gcgcgcctg  tcctgctct  caatcctgc  ctcggggcg  acggagtga  180
ccccgcccc  accatggta  tgttcaatg  ccttcttaa  atcaaaatc  gcgaggccg  240
gagcttgaa  cccacagcc  ggtcgctgc  ccatgcggt  ggaccccgg  cccagacgt  300
ccttctgga  ccctacatt  cccttaacg  ggacgactc  cgcatcggc  aaacagcca  360
caagcagaa  accaacagt  cggcctggc  cgatgagtt  gtcactgat  tgtgcaatg  420
gcgcaagat  gagctggct  tctttcacg  tgctcctat  ggctacgac  acttcgtgg  480
caactgcac  atccagttc  aggagctgc  gcagaatgg  agccgtcac  tcgaggact  540
gattgatct  gagccagaa  gaaaagtct  cgtgatcat  gatctctcg  gatcatcgg  600
cgaagcccc  aaagacaat  aagaacgag  gtttaggga  cggatgcgg  caaggaagc  660
ccaaggggc  gtcaggcgc  gggtccacc  ggtcaatgg  cacaagttc  tggccacct  720
cttgcggca  cccacctac  gctcccact  tagggattt  atctggggt  tcataggaa  780
acagggata  caatgtcaa  tttgtacct  cgtcgtcca  aaacgatgc  atgagctca  840
tattacgaa  tgcgctggg  taaagaaac  ggaaacccc  gacgaggtg  gctcccaac  900
cttcagcgt  aacatgccc  acaagttcg  gatccacaa  tacaaggtc  ccacgttct  960
tgaccactg  ggctccctg  tctggggcc  cttgcggca  ggcctgcag  gtaaagtct  1020
caaaatgaa  gttcaccgt  gatgcgaga  caacgtggc  cccaattgt  gggtggacg  1080
cagaggaat  gccaaggtg  tggccgatc  tggcgttac  ccagacaaa  tcaccaaca  1140
tggccagag  aggaaaaag  tcgctgctg  tgctgagtc  ccacagccg  cttctggaa  1200
ctccccatc  gaagacgac  gatccaagt  agcgcccac  tccccttgt  accaggaac  1260
aaaagaact  gaaaacaac  tccggaagg  cttgtcatt  gacaaccga  gagaggagc  1320
ccgagcctc  tcgtctact  atggccagc  ggcaagccc  ggcgagaac  gtgaagtcc  1380
gcaaggcca  gccaagcgc  tgggcctgg  tgagttcaa  ttcatcaag  tgttaggca  1440
aggcagctt  ggcaaggtc  tgctggccg  gctcaaggg  aaggatgaa  tctatgctg  1500
gaaggtctt  aagaaggac  tcatcctgc  ggatgacga  gtggactgc  cgatgacag  1560
gaagaggat  ttggctctg  cgcggaaac  cccttatct  acccaactc  attgctgct  1620
ccagaccaa  gaccggctc  tcttcgtca  ggaatatgt  aacggtgga  acctcatgt  1680
ccagattca  cggtcccga  aattcgatg  gcctcgttc  gggttctat  ctgccgagg  1740
cacatctgc  ctcatgttt  tccaccaac  tggagtgat  tacagggat  tgaaactgg  1800
caacatcct  ctagatgca  aaggtcact  caagctggc  gactttggg  tgtgcaagg  1860
agggattct  aatggcgtg  caactacca  cttctgtgg  actcctgac  acatagctc  1920
agagatcct  caggagttg  agtacggcc  ctcagtgga  tggtgggcc  tgggcgtgc  1980
gatgtacga  atgatggcc  ggcagcccc  ctttgaagc  gacaacgag  acgacttgt  2040
tgaatccat  cttcacgat  acgttctct  ccctgtctg  cttagcaag  aggctgtca  2100
catcctgaa  gctttcatg  ccaagaacc  gcacaagcg  ctgggctgc  tggcagcac  2160
gaacgggga  gatgccatc  agcaacatc  attcttcaa  gagattgac  gggtactgc  2220
ggagcagaa  aaaatgaag  cccccttca  gccgagaat  aaaaccaag  gagatgtca  2280
taactttga  caagacttt  cccgggaag  gccaatact  acacttgtg  atgaagcaa  2340
cgtgaagca  atcaaccag  aagaattca  aggcttctc  tactttggt  aagacctga  2400
gccctgaga  actgcttca  atggagtta  ctcactgca  ggagggtgt  gagacaatc  2460
cgtgttgca  aggctcaga  tgtctcgaa  tattcgtcc  ccccagagc  ccagtccca  2520
atctgctct  ttatttatt  catcccctc  tcccaggcc  tgtccttcc  caccctccc  2580
gtgaccaga  ggccctctt  ggtccagac  caccaagat  acagatttg  actgcgtct  2640
ctctgtgtg  agtgctagg  ctggagtag  cgtccaccc  caaccctga  gcagcccgg  2700
attc  2704



<210> 3397
<211> 737
<212> PRT
<213> Rattus norvegicus
<308> AAA41872
<400> 3397

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
  1               5                  10                  15
Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
             20                  25                  30
Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
         35                  40                  45
Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
     50                  55                  60
Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
 65                  70                  75                  80
Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                 85                  90                  95
Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
             100                105                110
Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Lys Val Tyr Val Ile 
         115                120                125
Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
     130                135                140
Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
 145                150                155                160
Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                 165                170                175
Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
             180                185                190
Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
         195                200                205
His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
     210                215                220
Lys Gln Glu Thr Pro Asp Glu Val Gly Ser Gln Arg Phe Ser Val Asn 
 225                230                235                240
Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                 245                250                255
Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
             260                265                270
Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
         275                280                285
Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
     290                295                300
Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
 305                310                315                320
Lys Lys Leu Ala Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Asn 
                 325                330                335
Ser Pro Ser Glu Asp Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
             340                345                350
Asp Gln Glu Leu Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
         355                360                365
Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ser Ser Ser Thr Asp Gly 
     370                375                380
Gln Leu Ala Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
 385                390                395                400
Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                 405                410                415
Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
             420                425                430
Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
         435                440                445
Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
     450                455                460
Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
 465                470                475                480
Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                 485                490                495
Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Gly Phe Tyr 
             500                505                510
Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
         515                520                525
Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
     530                535                540
His Ser Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
 545                550                555                560
Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                 565                570                575
Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
             580                585                590
Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
         595                600                605
Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
     610                615                620
Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
 625                630                635                640
Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ala Gln 
                 645                650                655
Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
             660                665                670
Trp Val Leu Leu Glu Gln Lys Lys Met Lys Pro Pro Phe Lys Pro Arg 
         675                680                685
Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
     690                695                700
Glu Glu Pro Ile Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
 705                710                715                720
Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                 725                730                735
Pro 
             740



<210> 3398
<211> 2244
<212> DNA
<213> Homo sapiens
<308> NM_005400
<400> 3398

ctccccgcc  cgaccatgg  agtgttcaa  ggccttctt  agatcaaaa  ctgcgaggc  60
gtgagcttg  agcccacag  ctggtcgct  cgccatgcg  tgggacccc  gccgcagac  120
ttccttctc  acccctaca  tgccctcaa  gtggacgac  cgcgcatcg  ccaaacggc  180
accaagcag  agaccaaca  cccggcctg  cacgacgag  tcgtcaccg  tgtgtgcaa  240
ggacgcaag  tcgagctgg  tgtctttca  gatgccccc  taggctacg  cgacttcgt  300
gccaactgc  ccatccagt  tgaggagct  ctgcagaac  ggagccgcc  cttcgagga  360
tggattgat  tggagccag  aggaagagt  tatgtgatc  tcgatctct  agggtcgtc  420
ggtgaagcc  ctaaagaca  tgaagagcg  gtgttcagg  aacgcatgc  gccgaggaa  480
cggcagggg  ccgtcaggc  cagggtcca  caggtcaac  gccacaagt  catggccac  540
tatcttcgg  agcccacct  ctgctccca  tgcagagac  tcatctggg  tgtcatagg  600
aagcaggga  accagtgtc  agtctgcac  tgcgtggtc  acaagcggt  ccacgagct  660
ataatcaca  agtgtgctg  gttaaagaa  caggagacc  ccgaccagg  gggctccca  720
cggttcagc  tcaacatgc  ccacaagtt  ggtatccac  actacaagg  ccctacctt  780
tgcgatcac  gtgggtccc  gctctgggg  ctcttgcgg  agggtttgc  gtgtaaagt  840
tgcaaaatg  atgttcacc  tcgatgtga  accaacgtg  ctcccaact  tggagtgga  900
gccagagga  tcgccaaag  actggccga  ctgggcgtt  ccccagaca  aatcaccaa  960
agcggccag  gaaggaaaa  gctcattgc  ggtgccgag  ccccgcagc  tgcttctgg  1020
agctcacca  ctgaggaag  tcgatccaa  tcagcaccc  cctcccctt  tgaccagga  1080
ataaaagaa  ttgagaaca  cattcggaa  gccttgtca  ttgacaacc  aggagagga  1140
caccgggca  catcgtctc  tgatggcca  ctgatgagc  ccggtgaga  tggcgaagt  1200
cggcaaggc  aggccaagc  cctgggcct  gatgagttc  acttcatca  ggtgttggg  1260
aaaggcagc  ttggcaagg  catgttggc  gaactcaag  gcaaagatg  agtatatgc  1320
gtgaaggtc  taaagaagg  cgtcatcct  caggatgat  acgtggact  cacaatgac  1380
gagaagagg  ttttggctc  ggcacggaa  cacccgtac  ttacccaac  ctactgctg  1440
ttccagacc  aggaccgcc  ctttttcgt  atggaatat  taaatggtg  agacctcat  1500
tttcagatt  agcgctccc  aaaattcga  gagcctcgt  cacggttct  tgctgcaga  1560
gtcacatcg  ccctcatgt  cctccatca  catggagtc  tctacaggg  tttgaaact  1620
gacaacatc  ttctggatg  agaaggtca  tgcaagctg  ctgacttcg  gatgtgcaa  1680
gaagggatt  tgaatggtg  gacgaccac  acgttctgt  ggactcctg  ctacatagc  1740
cctgagatc  tgcaggagt  ggagtatgg  ccctccgtg  actggtggg  cctgggggt  1800
ctgatgtac  agatgatgg  tggacagcc  ccctttgag  ccgacaatg  ggacgacct  1860
tttgagtcc  tcctccatg  cgacgtgct  tacccagtc  ggctcagca  ggaggctgt  1920
agcatcttg  aagctttca  gacgaagaa  ccccacaag  gcctgggct  tgtggcatc  1980
cagaatggc  aggacgcca  caagcagca  ccattcttc  aagagattg  ctgggtgct  2040
ctggagcag  agaagatca  gccaccctt  aaaccacgc  ttaaaacca  aagagacgt  2100
aataatttt  accaagact  tacccggga  gagccggta  tcacccttg  ggacgaagc  2160
attgtaaag  agatcaacc  ggaggaatt  aaaggtttc  cctactttg  tgaagacct  2220
atgccctga  agcccactg  agtt  2244



<210> 3399
<211> 737
<212> PRT
<213> Homo sapiens
<308> Q02156
<400> 3399

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
  1               5                  10                  15
Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
             20                  25                  30
Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
         35                  40                  45
Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
     50                  55                  60
Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
 65                  70                  75                  80
Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                 85                  90                  95
Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
             100                105                110
Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Arg Val Tyr Val Ile 
         115                120                125
Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
     130                135                140
Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
 145                150                155                160
Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                 165                170                175
Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
             180                185                190
Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
         195                200                205
His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
     210                215                220
Lys Gln Glu Thr Pro Asp Gln Val Gly Ser Gln Arg Phe Ser Val Asn 
 225                230                235                240
Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                 245                250                255
Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
             260                265                270
Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
         275                280                285
Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
     290                295                300
Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
 305                310                315                320
Lys Lys Leu Ile Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Ser 
                 325                330                335
Ser Pro Ser Glu Glu Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
             340                345                350
Asp Gln Glu Ile Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
         355                360                365
Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ala Ser Ser Pro Asp Gly 
     370                375                380
Gln Leu Met Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
 385                390                395                400
Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                 405                410                415
Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
             420                425                430
Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
         435                440                445
Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
     450                455                460
Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
 465                470                475                480
Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                 485                490                495
Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Arg Phe Tyr 
             500                505                510
Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
         515                520                525
Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
     530                535                540
His Cys Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
 545                550                555                560
Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                 565                570                575
Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
             580                585                590
Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
         595                600                605
Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
     610                615                620
Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
 625                630                635                640
Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ser Gln 
                 645                650                655
Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
             660                665                670
Trp Val Leu Leu Glu Gln Lys Lys Ile Lys Pro Pro Phe Lys Pro Arg 
         675                680                685
Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
     690                695                700
Glu Glu Pro Val Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
 705                710                715                720
Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                 725                730                735
Pro 
             740



<210> 3400
<211> 2704
<212> DNA
<213> Rattus norvegicus
<308> M18331
<400> 3400

gaattccgg  atccggcga  gaaatacat  cactcgctg  gaatcgccg  cgccaggac  60
cagcgccac  aggtgtagc  agtgagtgg  gtggggcaa  aggggaccc  ggagtcccc  120
caggctccc  gcgcgcctg  tcctgctct  caatcctgc  ctcggggcg  acggagtga  180
ccccgcccc  accatggta  tgttcaatg  ccttcttaa  atcaaaatc  gcgaggccg  240
gagcttgaa  cccacagcc  ggtcgctgc  ccatgcggt  ggaccccgg  cccagacgt  300
ccttctgga  ccctacatt  cccttaacg  ggacgactc  cgcatcggc  aaacagcca  360
caagcagaa  accaacagt  cggcctggc  cgatgagtt  gtcactgat  tgtgcaatg  420
gcgcaagat  gagctggct  tctttcacg  tgctcctat  ggctacgac  acttcgtgg  480
caactgcac  atccagttc  aggagctgc  gcagaatgg  agccgtcac  tcgaggact  540
gattgatct  gagccagaa  gaaaagtct  cgtgatcat  gatctctcg  gatcatcgg  600
cgaagcccc  aaagacaat  aagaacgag  gtttaggga  cggatgcgg  caaggaagc  660
ccaaggggc  gtcaggcgc  gggtccacc  ggtcaatgg  cacaagttc  tggccacct  720
cttgcggca  cccacctac  gctcccact  tagggattt  atctggggt  tcataggaa  780
acagggata  caatgtcaa  tttgtacct  cgtcgtcca  aaacgatgc  atgagctca  840
tattacgaa  tgcgctggg  taaagaaac  ggaaacccc  gacgaggtg  gctcccaac  900
cttcagcgt  aacatgccc  acaagttcg  gatccacaa  tacaaggtc  ccacgttct  960
tgaccactg  ggctccctg  tctggggcc  cttgcggca  ggcctgcag  gtaaagtct  1020
caaaatgaa  gttcaccgt  gatgcgaga  caacgtggc  cccaattgt  gggtggacg  1080
cagaggaat  gccaaggtg  tggccgatc  tggcgttac  ccagacaaa  tcaccaaca  1140
tggccagag  aggaaaaag  tcgctgctg  tgctgagtc  ccacagccg  cttctggaa  1200
ctccccatc  gaagacgac  gatccaagt  agcgcccac  tccccttgt  accaggaac  1260
aaaagaact  gaaaacaac  tccggaagg  cttgtcatt  gacaaccga  gagaggagc  1320
ccgagcctc  tcgtctact  atggccagc  ggcaagccc  ggcgagaac  gtgaagtcc  1380
gcaaggcca  gccaagcgc  tgggcctgg  tgagttcaa  ttcatcaag  tgttaggca  1440
aggcagctt  ggcaaggtc  tgctggccg  gctcaaggg  aaggatgaa  tctatgctg  1500
gaaggtctt  aagaaggac  tcatcctgc  ggatgacga  gtggactgc  cgatgacag  1560
gaagaggat  ttggctctg  cgcggaaac  cccttatct  acccaactc  attgctgct  1620
ccagaccaa  gaccggctc  tcttcgtca  ggaatatgt  aacggtgga  acctcatgt  1680
ccagattca  cggtcccga  aattcgatg  gcctcgttc  gggttctat  ctgccgagg  1740
cacatctgc  ctcatgttt  tccaccaac  tggagtgat  tacagggat  tgaaactgg  1800
caacatcct  ctagatgca  aaggtcact  caagctggc  gactttggg  tgtgcaagg  1860
agggattct  aatggcgtg  caactacca  cttctgtgg  actcctgac  acatagctc  1920
agagatcct  caggagttg  agtacggcc  ctcagtgga  tggtgggcc  tgggcgtgc  1980
gatgtacga  atgatggcc  ggcagcccc  ctttgaagc  gacaacgag  acgacttgt  2040
tgaatccat  cttcacgat  acgttctct  ccctgtctg  cttagcaag  aggctgtca  2100
catcctgaa  gctttcatg  ccaagaacc  gcacaagcg  ctgggctgc  tggcagcac  2160
gaacgggga  gatgccatc  agcaacatc  attcttcaa  gagattgac  gggtactgc  2220
ggagcagaa  aaaatgaag  cccccttca  gccgagaat  aaaaccaag  gagatgtca  2280
taactttga  caagacttt  cccgggaag  gccaatact  acacttgtg  atgaagcaa  2340
cgtgaagca  atcaaccag  aagaattca  aggcttctc  tactttggt  aagacctga  2400
gccctgaga  actgcttca  atggagtta  ctcactgca  ggagggtgt  gagacaatc  2460
cgtgttgca  aggctcaga  tgtctcgaa  tattcgtcc  ccccagagc  ccagtccca  2520
atctgctct  ttatttatt  catcccctc  tcccaggcc  tgtccttcc  caccctccc  2580
gtgaccaga  ggccctctt  ggtccagac  caccaagat  acagatttg  actgcgtct  2640
ctctgtgtg  agtgctagg  ctggagtag  cgtccaccc  caaccctga  gcagcccgg  2700
attc  2704



<210> 3401
<211> 737
<212> PRT
<213> Rattus norvegicus
<308> AAA41872
<400> 3401

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
  1               5                  10                  15
Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
             20                  25                  30
Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
         35                  40                  45
Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
     50                  55                  60
Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
 65                  70                  75                  80
Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                 85                  90                  95
Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
             100                105                110
Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Lys Val Tyr Val Ile 
         115                120                125
Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
     130                135                140
Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
 145                150                155                160
Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                 165                170                175
Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
             180                185                190
Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
         195                200                205
His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
     210                215                220
Lys Gln Glu Thr Pro Asp Glu Val Gly Ser Gln Arg Phe Ser Val Asn 
 225                230                235                240
Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                 245                250                255
Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
             260                265                270
Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
         275                280                285
Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
     290                295                300
Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
 305                310                315                320
Lys Lys Leu Ala Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Asn 
                 325                330                335
Ser Pro Ser Glu Asp Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
             340                345                350
Asp Gln Glu Leu Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
         355                360                365
Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ser Ser Ser Thr Asp Gly 
     370                375                380
Gln Leu Ala Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
 385                390                395                400
Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                 405                410                415
Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
             420                425                430
Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
         435                440                445
Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
     450                455                460
Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
 465                470                475                480
Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                 485                490                495
Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Gly Phe Tyr 
             500                505                510
Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
         515                520                525
Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
     530                535                540
His Ser Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
 545                550                555                560
Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                 565                570                575
Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
             580                585                590
Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
         595                600                605
Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
     610                615                620
Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
 625                630                635                640
Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ala Gln 
                 645                650                655
Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
             660                665                670
Trp Val Leu Leu Glu Gln Lys Lys Met Lys Pro Pro Phe Lys Pro Arg 
         675                680                685
Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
     690                695                700
Glu Glu Pro Ile Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
 705                710                715                720
Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                 725                730                735
Pro 
             740



<210> 3402
<211> 2244
<212> DNA
<213> Homo sapiens
<308> NM_005400
<400> 3402

ctccccgcc  cgaccatgg  agtgttcaa  ggccttctt  agatcaaaa  ctgcgaggc  60
gtgagcttg  agcccacag  ctggtcgct  cgccatgcg  tgggacccc  gccgcagac  120
ttccttctc  acccctaca  tgccctcaa  gtggacgac  cgcgcatcg  ccaaacggc  180
accaagcag  agaccaaca  cccggcctg  cacgacgag  tcgtcaccg  tgtgtgcaa  240
ggacgcaag  tcgagctgg  tgtctttca  gatgccccc  taggctacg  cgacttcgt  300
gccaactgc  ccatccagt  tgaggagct  ctgcagaac  ggagccgcc  cttcgagga  360
tggattgat  tggagccag  aggaagagt  tatgtgatc  tcgatctct  agggtcgtc  420
ggtgaagcc  ctaaagaca  tgaagagcg  gtgttcagg  aacgcatgc  gccgaggaa  480
cggcagggg  ccgtcaggc  cagggtcca  caggtcaac  gccacaagt  catggccac  540
tatcttcgg  agcccacct  ctgctccca  tgcagagac  tcatctggg  tgtcatagg  600
aagcaggga  accagtgtc  agtctgcac  tgcgtggtc  acaagcggt  ccacgagct  660
ataatcaca  agtgtgctg  gttaaagaa  caggagacc  ccgaccagg  gggctccca  720
cggttcagc  tcaacatgc  ccacaagtt  ggtatccac  actacaagg  ccctacctt  780
tgcgatcac  gtgggtccc  gctctgggg  ctcttgcgg  agggtttgc  gtgtaaagt  840
tgcaaaatg  atgttcacc  tcgatgtga  accaacgtg  ctcccaact  tggagtgga  900
gccagagga  tcgccaaag  actggccga  ctgggcgtt  ccccagaca  aatcaccaa  960
agcggccag  gaaggaaaa  gctcattgc  ggtgccgag  ccccgcagc  tgcttctgg  1020
agctcacca  ctgaggaag  tcgatccaa  tcagcaccc  cctcccctt  tgaccagga  1080
ataaaagaa  ttgagaaca  cattcggaa  gccttgtca  ttgacaacc  aggagagga  1140
caccgggca  catcgtctc  tgatggcca  ctgatgagc  ccggtgaga  tggcgaagt  1200
cggcaaggc  aggccaagc  cctgggcct  gatgagttc  acttcatca  ggtgttggg  1260
aaaggcagc  ttggcaagg  catgttggc  gaactcaag  gcaaagatg  agtatatgc  1320
gtgaaggtc  taaagaagg  cgtcatcct  caggatgat  acgtggact  cacaatgac  1380
gagaagagg  ttttggctc  ggcacggaa  cacccgtac  ttacccaac  ctactgctg  1440
ttccagacc  aggaccgcc  ctttttcgt  atggaatat  taaatggtg  agacctcat  1500
tttcagatt  agcgctccc  aaaattcga  gagcctcgt  cacggttct  tgctgcaga  1560
gtcacatcg  ccctcatgt  cctccatca  catggagtc  tctacaggg  tttgaaact  1620
gacaacatc  ttctggatg  agaaggtca  tgcaagctg  ctgacttcg  gatgtgcaa  1680
gaagggatt  tgaatggtg  gacgaccac  acgttctgt  ggactcctg  ctacatagc  1740
cctgagatc  tgcaggagt  ggagtatgg  ccctccgtg  actggtggg  cctgggggt  1800
ctgatgtac  agatgatgg  tggacagcc  ccctttgag  ccgacaatg  ggacgacct  1860
tttgagtcc  tcctccatg  cgacgtgct  tacccagtc  ggctcagca  ggaggctgt  1920
agcatcttg  aagctttca  gacgaagaa  ccccacaag  gcctgggct  tgtggcatc  1980
cagaatggc  aggacgcca  caagcagca  ccattcttc  aagagattg  ctgggtgct  2040
ctggagcag  agaagatca  gccaccctt  aaaccacgc  ttaaaacca  aagagacgt  2100
aataatttt  accaagact  tacccggga  gagccggta  tcacccttg  ggacgaagc  2160
attgtaaag  agatcaacc  ggaggaatt  aaaggtttc  cctactttg  tgaagacct  2220
atgccctga  agcccactg  agtt  2244



<210> 3403
<211> 737
<212> PRT
<213> Homo sapiens
<308> Q02156
<400> 3403

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
  1               5                  10                  15
Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
             20                  25                  30
Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
         35                  40                  45
Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
     50                  55                  60
Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
 65                  70                  75                  80
Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                 85                  90                  95
Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
             100                105                110
Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Arg Val Tyr Val Ile 
         115                120                125
Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
     130                135                140
Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
 145                150                155                160
Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                 165                170                175
Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
             180                185                190
Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
         195                200                205
His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
     210                215                220
Lys Gln Glu Thr Pro Asp Gln Val Gly Ser Gln Arg Phe Ser Val Asn 
 225                230                235                240
Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                 245                250                255
Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
             260                265                270
Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
         275                280                285
Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
     290                295                300
Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
 305                310                315                320
Lys Lys Leu Ile Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Ser 
                 325                330                335
Ser Pro Ser Glu Glu Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
             340                345                350
Asp Gln Glu Ile Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
         355                360                365
Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ala Ser Ser Pro Asp Gly 
     370                375                380
Gln Leu Met Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
 385                390                395                400
Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                 405                410                415
Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
             420                425                430
Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
         435                440                445
Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
     450                455                460
Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
 465                470                475                480
Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                 485                490                495
Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Arg Phe Tyr 
             500                505                510
Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
         515                520                525
Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
     530                535                540
His Cys Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
 545                550                555                560
Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                 565                570                575
Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
             580                585                590
Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
         595                600                605
Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
     610                615                620
Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
 625                630                635                640
Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ser Gln 
                 645                650                655
Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
             660                665                670
Trp Val Leu Leu Glu Gln Lys Lys Ile Lys Pro Pro Phe Lys Pro Arg 
         675                680                685
Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
     690                695                700
Glu Glu Pro Val Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
 705                710                715                720
Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                 725                730                735
Pro 
             740



<210> 3404
<211> 1832
<212> DNA
<213> Rattus norvegicus
<308> M18332
<400> 3404

gaattccgt  ctgaagagg  agcagagaa  gccgagtcc  tctaccgcc  tggagccag  60
agatggagg  agctatacc  agccaacgg  cacctcttc  aagccaagc  ctttaacag  120
agagcgtac  gtggccagt  cagcgaaag  atatggggc  tcgcgaggc  ggggtacag  180
tgcatcaac  gcaagctgc  tgtccataa  cgctgccac  tcctcgtcc  gctgacctg  240
aggaggcat  tggattctg  catgccttc  caagagcct  cagtagatg  caagaacga  300
ggtgtagac  ttccttcag  agaaactga  ggaattgct  atatttctt  atctcggaa  360
catgacaat  tcaaagatg  ttctgagga  cttaagcct  tcatcgatg  ggtggatgg  420
atcaaaatc  ctcaggggc  ggggctgca  gactttgac  tcatcagag  catcgggcg  480
ggaagctat  ccaaggtcc  cctggtgcg  ttgaagaaa  acgaccaga  ttacgccat  540
aaggtggtg  agaaggagc  cgtccacga  gatgaggat  tcgactggg  gcagacaga  600
aagcacgtg  tcgagcagg  atccagcaa  cccttcctg  ttggcttac  ctcctgctt  660
cagacaacg  gccggttgt  cctggtcat  gagtatgtc  acggggggg  cctcatgtt  720
cacatgcag  ggcagagga  gcttccaga  gaacacgcc  ggttctatg  tgctgagat  780
tgtatcgct  tcaacttcc  acatgagag  gggatcatc  accgggacc  aaaactgga  840
aacgtcctc  tcgatgccg  tggacacat  aagctgacg  actacggca  gtgcaagga  900
ggcctaggc  ccggcgaca  aacaagcac  ttttgtgga  ccccgaact  tatcgcccc  960
gaaatcctg  gaggagaag  gtacgggtt  agcgtggac  ggtgggcgc  gggtgtcct  1020
atgtttgag  tgatggctg  gcgctcccc  tttgacatc  tcacagaca  ccctgacat  1080
aatactgaa  actaccttt  ccaagttat  ctggaaaag  caattcgga  tccccgttt  1140
ctgtctgtc  aggcctcac  cgtcttgaa  ggattttta  ataaggatc  caaagagag  1200
cttggctgc  ggccgcaga  tgggttttc  gacatcaag  cccatgcct  cttccgaag  1260
atagactgg  acctgcttg  aaagaagca  accctgcct  ccttccagc  ccagatcac  1320
gatgactat  gcctggaca  cttcgacac  cagttcacc  gcgagcccg  acagctgac  1380
ccagatgat  aggacgtca  aaagaggat  gaccagtcc  agttcgaag  cttcgagta  1440
atcaacccg  ttctgctgt  tgctgagga  tccgtgtga  gccatgagc  tctctgttg  1500
ggacacgtc  gtgaatgac  ctgtcactt  acccttaac  acagcatat  catgccagg  1560
cagacaccg  ggctccaag  agccagaga  ggatgctgg  caccaagac  gcagagggg  1620
cacccaaca  gcacttcta  acagagcaa  ctcttgtgt  caggcccca  aggctggct  1680
tgtgctgga  ggaaccact  cctgtgccc  tggcggccc  accagaggg  gagacagcc  1740
cgccgtctt  aaaggcgca  atcttccac  gagacagaa  tcgatgcac  gatccgctc  1800
aggaaaagt  agctgtaat  cccccggaa  tc  1832



<210> 3405
<211> 592
<212> PRT
<213> Rattus norvegicus
<308> AAA41878
<400> 3405

Met Pro Ser Arg Thr Asp Pro Lys Met Asp Arg Ser Gly Gly Arg Val 
  1               5                  10                  15
Arg Leu Lys Ala His Tyr Gly Gly Asp Ile Leu Ile Thr Ser Val Asp 
             20                  25                  30
Pro Thr Thr Thr Phe Gln Asp Leu Cys Glu Glu Val Arg Asp Met Cys 
         35                  40                  45
Gly Leu His Gln Gln His Pro Leu Thr Leu Lys Trp Val Asp Ser Glu 
     50                  55                  60
Gly Asp Pro Cys Thr Val Ser Ser Gln Met Glu Leu Glu Glu Ala Phe 
 65                  70                  75                  80
Arg Leu Ala Cys Gln Gly Arg Asp Glu Val Leu Ile Ile His Val Phe 
                 85                  90                  95
Pro Ser Ile Pro Glu Gln Pro Gly Met Pro Cys Pro Gly Glu Asp Lys 
             100                105                110
Ser Ile Tyr Arg Arg Gly Ala Arg Arg Trp Arg Lys Leu Tyr Arg Ala 
         115                120                125
Asn Gly His Leu Phe Gln Ala Lys Arg Phe Asn Arg Arg Ala Tyr Cys 
     130                135                140
Gly Gln Cys Ser Glu Arg Ile Trp Gly Leu Ala Arg Gln Gly Tyr Arg 
 145                150                155                160
Cys Ile Asn Cys Lys Leu Leu Val His Lys Arg Cys His Val Leu Val 
                 165                170                175
Pro Leu Thr Cys Arg Arg His Met Asp Ser Val Met Pro Ser Gln Glu 
             180                185                190
Pro Pro Val Asp Asp Lys Asn Asp Gly Val Asp Leu Pro Ser Glu Glu 
         195                200                205
Thr Asp Gly Ile Ala Tyr Ile Ser Ser Ser Arg Lys His Asp Asn Ile 
     210                215                220
Lys Asp Asp Ser Glu Asp Leu Lys Pro Val Ile Asp Gly Val Asp Gly 
 225                230                235                240
Ile Lys Ile Ser Gln Gly Leu Gly Leu Gln Asp Phe Asp Leu Ile Arg 
                 245                250                255
Val Ile Gly Arg Gly Ser Tyr Ala Lys Val Leu Leu Val Arg Leu Lys 
             260                265                270
Lys Asn Asp Gln Ile Tyr Ala Met Lys Val Val Lys Lys Glu Leu Val 
         275                280                285
His Asp Asp Glu Asp Ile Asp Trp Val Gln Thr Glu Lys His Val Phe 
     290                295                300
Glu Gln Ala Ser Ser Asn Pro Phe Leu Val Gly Leu His Ser Cys Phe 
 305                310                315                320
Gln Thr Thr Ser Arg Leu Phe Leu Val Ile Glu Tyr Val Asn Gly Gly 
                 325                330                335
Asp Leu Met Phe His Met Gln Arg Gln Arg Lys Leu Pro Glu Glu His 
             340                345                350
Ala Arg Phe Tyr Ala Ala Glu Ile Cys Ile Ala Leu Asn Phe Leu His 
         355                360                365
Glu Arg Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Leu Leu 
     370                375                380
Asp Ala Asp Gly His Ile Lys Leu Thr Asp Tyr Gly Met Cys Lys Glu 
 385                390                395                400
Gly Leu Gly Pro Gly Asp Thr Thr Ser Thr Phe Cys Gly Thr Pro Asn 
                 405                410                415
Tyr Ile Ala Pro Glu Ile Leu Arg Gly Glu Glu Tyr Gly Phe Ser Val 
             420                425                430
Asp Trp Trp Ala Leu Gly Val Leu Met Phe Glu Met Met Ala Gly Arg 
         435                440                445
Ser Pro Phe Asp Ile Ile Thr Asp Asn Pro Asp Met Asn Thr Glu Asp 
     450                455                460
Tyr Leu Phe Gln Val Ile Leu Glu Lys Pro Ile Arg Ile Pro Arg Phe 
 465                470                475                480
Leu Ser Val Lys Ala Ser His Val Leu Lys Gly Phe Leu Asn Lys Asp 
                 485                490                495
Pro Lys Glu Arg Leu Gly Cys Arg Pro Gln Thr Gly Phe Ser Asp Ile 
             500                505                510
Lys Ser His Ala Phe Phe Arg Ser Ile Asp Trp Asp Leu Leu Glu Lys 
         515                520                525
Lys Gln Thr Leu Pro Pro Phe Gln Pro Gln Ile Thr Asp Asp Tyr Gly 
     530                535                540
Leu Asp Asn Phe Asp Thr Gln Phe Thr Ser Glu Pro Val Gln Leu Thr 
 545                550                555                560
Pro Asp Asp Glu Asp Val Ile Lys Arg Ile Asp Gln Ser Glu Phe Glu 
                 565                570                575
Gly Phe Glu Tyr Ile Asn Pro Leu Leu Leu Ser Ala Glu Glu Ser Val 
             580                585                590



<210> 3406
<211> 2146
<212> DNA
<213> Homo sapiens
<308> Z15108
<400> 3406

cccaagatg  aagggagcg  cggccgcgt  cgcctcaag  cgcattacg  gggggacat  60
ttcatcacc  gcgtggacg  cgccacgac  ttcgaggag  tctgtgagg  agtgagaga  120
atgtgtcgt  tgcaccagc  gcacccgct  accctcaag  gggtggaca  cgaaggtga  180
ccttgcacg  tgtcctccc  gatggagct  gaagaggct  tccgcctgg  ccgtcagtg  240
agggatgaa  gcctcatca  tcatgtttt  ccgagcacc  ctgagcagc  tggcctgcc  300
tgtccggga  aagacaaat  tatctaccg  cggggagcc  gaagatgga  gaagctgta  360
cgtgccaac  gccacctct  ccaagccaa  cgctttaac  ggagagcgt  ctgcggtca  420
tgcagcgag  ggatatggg  cctcgcgag  caaggctac  ggtgcatca  ctgcaaact  480
ctggtccat  agcgctgcc  cggcctcgt  ccgctgacc  gcaggaagc  tatggattc  540
gtcatgcct  cccaagagc  tccagtaga  gacaagaac  aggacgccg  ccttccttc  600
gaggagaca  atggaattg  ttacatttc  tcatcccgg  agcatgaca  cattaaaga  660
gactcggag  accttaagc  agttatcga  gggatggat  gaatcaaaa  ctctcaggg  720
cttgggctg  aggactttg  cctaatcag  gtcatcggg  gcgggagct  cgccaaggt  780
ctcctggtg  ggttgaaga  gaatgacca  atttacgcc  tgaaagtgg  gaagaaaga  840
ctggtgcat  atgacgagg  tattgactg  gtacagaca  agaagcacg  gtttgagca  900
gcatccagc  accccttcc  ggtcggatt  cactcctgc  tccagacga  aagtcggtt  960
ttcctggtc  ttgagtacg  caacggcgg  gacctgatg  tccacatgc  gaggcagag  1020
aagctccct  aggagcacg  caggttcta  gcggccgag  tctgcatcg  cctcaactt  1080
ctgcacgag  gggggatca  ctacaggga  ctgaagctg  acaacgtcc  cctggatgc  1140
gacgggcac  tcaagctca  agactacgg  atgtgcaag  aaggcctgg  ccctggtga  1200
acaacgagc  ctttctgcg  aaccccgaa  tacatcgcc  ccgaaatcc  gcggggaga  1260
gagtacggg  tcagcgtgg  ctggtgggc  ctgggagtc  tcatgtttg  gatgatggc  1320
gggcgctcc  cgttcgaca  catcaccga  aacccggac  tgaacacag  ggactacct  1380
ttccaagtg  tcctggaga  gcccatccg  atcccccgg  tcctgtccg  caaagcctc  1440
catgtttta  aaggatttt  aaataagga  cccaaagag  ggctcggct  ccggccaca  1500
actggattt  ctgacatca  gtcccacgc  ttcttccgc  gcatagact  ggacttgct  1560
gagaagaag  aggcgctcc  tccattcca  ccacagatc  cagacgact  cggtctgga  1620
aactttgac  cacagttca  cagcgagcc  gtgcagctg  ccccagacg  tgaggatgc  1680
ataaagagg  tcgaccagt  agagttcga  ggctttgag  atatcaacc  attattgct  1740
tccaccgag  agtcggtgt  aggccgcgt  cgtctctgt  gtggacacg  gtgattgac  1800
ctttaactg  atccttaac  accgcatat  catgccagg  tgggcacgg  tccgagggc  1860
gccagggac  gacgcttgc  ccgagaccg  agagggaag  gtcagcggg  gctgctggg  1920
gcagaacag  ccctcacac  tggcccggc  ggcagcttc  tgctggagg  acttgctgc  1980
gtgcctgcg  cgcggcgga  ccgcgggga  cctgccgag  gggctgtca  gcggtttcc  2040
aggtgcaca  tttccacgg  aacagaact  gatgcactg  cctgctccg  caggaaagt  2100
agcgtgtag  gtcctgagg  ataaaatgt  ccgatgaaa  aaaaaa  2146



<210> 3407
<211> 592
<212> PRT
<213> Homo sapiens
<308> Q05513
<400> 3407

Met Pro Ser Arg Thr Asp Pro Lys Met Glu Gly Ser Gly Gly Arg Val 
  1               5                  10                  15
Arg Leu Lys Ala His Tyr Gly Gly Asp Ile Phe Ile Thr Ser Val Asp 
             20                  25                  30
Ala Ala Thr Thr Phe Glu Glu Leu Cys Glu Glu Val Arg Asp Met Cys 
         35                  40                  45
Arg Leu His Gln Gln His Pro Leu Thr Leu Lys Trp Val Asp Ser Glu 
     50                  55                  60
Gly Asp Pro Cys Thr Val Ser Ser Gln Met Glu Leu Glu Glu Ala Phe 
 65                  70                  75                  80
Arg Leu Ala Arg Gln Cys Arg Asp Glu Gly Leu Ile Ile His Val Phe 
                 85                  90                  95
Pro Ser Thr Pro Glu Gln Pro Gly Leu Pro Cys Pro Gly Glu Asp Lys 
             100                105                110
Ser Ile Tyr Arg Arg Gly Ala Arg Arg Trp Arg Lys Leu Tyr Arg Ala 
         115                120                125
Asn Gly His Leu Phe Gln Ala Lys Arg Phe Asn Arg Arg Ala Tyr Cys 
     130                135                140
Gly Gln Cys Ser Glu Arg Ile Trp Gly Leu Ala Arg Gln Gly Tyr Arg 
 145                150                155                160
Cys Ile Asn Cys Lys Leu Leu Val His Lys Arg Cys His Gly Leu Val 
                 165                170                175
Pro Leu Thr Cys Arg Lys His Met Asp Ser Val Met Pro Ser Gln Glu 
             180                185                190
Pro Pro Val Asp Asp Lys Asn Glu Asp Ala Asp Leu Pro Ser Glu Glu 
         195                200                205
Thr Asp Gly Ile Ala Tyr Ile Ser Ser Ser Arg Lys His Asp Ser Ile 
     210                215                220
Lys Asp Asp Ser Glu Asp Leu Lys Pro Val Ile Asp Gly Met Asp Gly 
 225                230                235                240
Ile Lys Ile Ser Gln Gly Leu Gly Leu Gln Asp Phe Asp Leu Ile Arg 
                 245                250                255
Val Ile Gly Arg Gly Ser Tyr Ala Lys Val Leu Leu Val Arg Leu Lys 
             260                265                270
Lys Asn Asp Gln Ile Tyr Ala Met Lys Val Val Lys Lys Glu Leu Val 
         275                280                285
His Asp Asp Glu Asp Ile Asp Trp Val Gln Thr Glu Lys His Val Phe 
     290                295                300
Glu Gln Ala Ser Ser Asn Pro Phe Leu Val Gly Leu His Ser Cys Phe 
 305                310                315                320
Gln Thr Thr Ser Arg Leu Phe Leu Val Ile Glu Tyr Val Asn Gly Gly 
                 325                330                335
Asp Leu Met Phe His Met Gln Arg Gln Arg Lys Leu Pro Glu Glu His 
             340                345                350
Ala Arg Phe Tyr Ala Ala Glu Ile Cys Ile Ala Leu Asn Phe Leu His 
         355                360                365
Glu Arg Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Leu Leu 
     370                375                380
Asp Ala Asp Gly His Ile Lys Leu Thr Asp Tyr Gly Met Cys Lys Glu 
 385                390                395                400
Gly Leu Gly Pro Gly Asp Thr Thr Ser Thr Phe Cys Gly Thr Pro Asn 
                 405                410                415
Tyr Ile Ala Pro Glu Ile Leu Arg Gly Glu Glu Tyr Gly Phe Ser Val 
             420                425                430
Asp Trp Trp Ala Leu Gly Val Leu Met Phe Glu Met Met Ala Gly Arg 
         435                440                445
Ser Pro Phe Asp Ile Ile Thr Asp Asn Pro Asp Met Asn Thr Glu Asp 
     450                455                460
Tyr Leu Phe Gln Val Ile Leu Glu Lys Pro Ile Arg Ile Pro Arg Phe 
 465                470                475                480
Leu Ser Val Lys Ala Ser His Val Leu Lys Gly Phe Leu Asn Lys Asp 
                 485                490                495
Pro Lys Glu Arg Leu Gly Cys Arg Pro Gln Thr Gly Phe Ser Asp Ile 
             500                505                510
Lys Ser His Ala Phe Phe Arg Ser Ile Asp Trp Asp Leu Leu Glu Lys 
         515                520                525
Lys Gln Ala Leu Pro Pro Phe Gln Pro Gln Ile Thr Asp Asp Tyr Gly 
     530                535                540
Leu Asp Asn Phe Asp Thr Gln Phe Thr Ser Glu Pro Val Gln Leu Thr 
 545                550                555                560
Pro Asp Asp Glu Asp Ala Ile Lys Arg Ile Asp Gln Ser Glu Phe Glu 
                 565                570                575
Gly Phe Glu Tyr Ile Asn Pro Leu Leu Leu Ser Thr Glu Glu Ser Val 
             580                585                590



<210> 3408
<211> 1159
<212> DNA
<213> Rattus norvegicus
<308> M18529
<400> 3408

ggccacacc  aaggaagcc  tagagagcc  gatatcaga  tattcttgg  agaggcagg  60
gaaaatgaa  gccaatctc  gctcctacc  tacatgttt  tgttagggg  gtcagataa  120
ctggtctgg  atctctgtc  gatgcatgg  actattgta  ctgaagaag  acatagttt  180
agggaagaa  ggcaataga  gggaggctc  gaatagctt  aaagggtca  acccaattt  240
ctttctaaa  tagctaggg  ctagggaat  actcaaaac  cacaagact  tatacatgt  300
tcctggctt  attgttcct  atctgtagg  ttaagtgtg  ttttctgtg  gtctgtcta  360
aacatgcat  atgcactga  agggagatt  tccttgtta  ttcatacca  ctctgcact  420
ccttcctca  gggctgatg  tgcaccaac  gtatccatc  tcccaccat  ctcggaaca  480
ttagatact  gaggtgcct  agtcgtgtg  ttcataaac  acttctatc  cagagacat  540
agtgtcaag  ggaagattg  tggcagtga  cgacgagat  gtatcctgg  cagtgttac  600
gatcaggac  gcaaagaca  cacgtacag  atgagcagc  ccctcacgt  gaacaaggc  660
gactatgaa  gtcataacc  ctatacctg  gaggttgtt  ataagacat  agcctctcc  720
gtcgtcaag  gcttcaaca  gaatgagtg  tagacccaa  ggtcctgag  tgccacctg  780
tccccagat  cttccaatc  tccctccta  ggtcttgga  acttcccca  aagcgacct  840
ccactgttg  ggtgctcca  acctcctcc  cacctcatc  tccttcctt  ccttggctt  900
gatcatgct  atatttggg  aatattaaa  aaagtgaat  tttgcactt  agatctttg  960
ctttcttac  aaatagtgg  taacagtta  ttatcctgt  acctggttt  tcttctaaa  1020
aagttaaat  tttagttgc  ctgaaatcc  ccacactta  acaacaaat  aaactctcc  1080
ccttgccct  cttggttgt  cactacatg  cagtcctct  taaggttca  aagtactat  1140
catggctta  ttctctggg  1159



<210> 3409
<211> 107
<212> PRT
<213> Rattus norvegicus
<308> M18529
<400> 3409

Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
  1               5                  10                  15
Leu Asp Thr Gly Gly Ala Ser Val Val Cys Phe Ile Asn Asn Phe Tyr 
             20                  25                  30
Pro Arg Asp Ile Ser Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Arg 
         35                  40                  45
Asp Gly Ile Leu Asp Ser Val Thr Asp Gln Asp Ser Lys Asp Ser Thr 
     50                  55                  60
Tyr Ser Met Ser Ser Thr Leu Thr Leu Asn Lys Ala Asp Tyr Glu Ser 
 65                  70                  75                  80
His Asn Leu Tyr Thr Cys Glu Val Val His Lys Thr Ser Ala Ser Pro 
                 85                  90                  95
Val Val Lys Ser Phe Asn Arg Asn Glu Cys Ter 
             100                105



<210> 3410
<211> 998
<212> DNA
<213> Homo sapiens
<308> S65921
<400> 3410

gcggaagtg  cggccgctc  ttggtgtgt  ttaactcag  aagataaaa  acgacataa  60
acaacagcc  ggactcagc  tggacatga  gacccctgc  cagtttctt  gaatcttgt  120
gctctggtt  ccaggtatg  aatgtgaca  caagatgac  cagtctcca  cttccatgt  180
tgcatctct  ggagagaga  tcactatca  ttgcaaggc  agtcaggac  ttaatagct  240
tttaagctg  ttccagcag  aaccaggga  atctcctaa  accctgatc  accgtgcaa  300
cagattggt  gatggggtc  catcaaggt  cagtggcag  ggatctggg  aagattatt  360
tctcaccat  agcagcctg  agtatgaag  tatgggaat  tattattgt  tacagtatg  420
tgagtttcc  cggacgttc  gtggaggca  caagctgga  atcaaacgg  ctgatgctg  480
accaactgt  tccatcttc  caccatcca  tgagcagtt  acatctgga  gtgcctcag  540
cgtgtgctt  ttgaacaac  tctacccca  agacatcaa  gtcaagtgg  agattgatg  600
cagtgaacg  caaaatggc  tcctgaaca  ttggactga  caggacagc  aagacagca  660
ctacagcat  agcagcacc  tcacgttga  caaggacga  tatgaacga  ataacagct  720
tacctgtga  gccactcac  agacatcaa  ttcacccat  gtcaagagc  tcaacagga  780
tgagtgtta  agacaaagg  cctgagacg  caccaccag  tccccagct  caccctatc  840
tcccttcta  ggtcttgga  gcttcccca  aagcgacct  ccactgttg  ggtgctcca  900
acctcctcc  cacctcctt  tcctcctcc  ccctttcct  ggcttttat  atgctaata  960
ttgcagaaa  tattcaata  agtcagtct  tgcacttg  998



<210> 3411
<211> 237
<212> PRT
<213> Homo sapiens
<308> S65921
<400> 3411

Met Asp Met Arg Thr Pro Ala Gln Phe Leu Gly Ile Leu Leu Leu Trp 
  1               5                  10                  15
Phe Pro Gly Met Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser 
             20                  25                  30
Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser 
         35                  40                  45
Gln Asp Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys 
     50                  55                  60
Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val 
 65                  70                  75                  80
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr 
                 85                  90                  95
Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln 
             100                105                110
Tyr Asp Glu Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
         115                120                125
Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
     130                135                140
Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn 
 145                150                155                160
Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu 
                 165                170                175
Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp 
             180                185                190
Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr 
         195                200                205
Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr 
     210                215                220
Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys Ter 
 225                230                235



<210> 3412
<211> 31737
<212> DNA
<213> Rattus norvegicus
<308> M19359
<400> 3412

gaattcttt  tttcacacc  tttccatga  ttataacat  tttattatt  actatattt  60
ttaacagct  ttaaccttc  ttatgactt  tcaatagtt  ttatacaca  atttatgta  120
gaaccactg  tttgatatc  ttgaataag  taaatattt  attaaatat  taaaatatg  180
tttttttgt  gttttcttt  taagacagg  ttttctgtg  agccctggc  gtcctgaaa  240
tcactctgt  gaccaggct  gcctcaaac  tagacatcc  catcaaaag  atgcgacat  300
accacctgg  tgagagtat  cttttatgg  ttttcattt  aggaaattg  ttatcttat  360
tatttggaa  tcttcattt  ccctgtaag  tttaaaccc  tatgtaaca  atctttctt  420
ccaatgttc  ttttatttc  agacaccga  ttttgtcac  aactaagag  aaggcaata  480
cttttcaat  ctcccagct  ttctgggga  catttaagt  ggtgtgttt  gtttgtttg  540
ttggttggt  ggtttggtt  attttattt  gtactagta  cttgtttta  tcagcatgg  600
tatgagcaa  atttcctgg  atagctaat  tccctacac  ttactttct  ttctataaa  660
gaaaacgta  tgggtacct  acagggtta  ttcaagaat  aaatgatta  catatgtac  720
aaggctcag  gaatcaccc  aaccatagc  tgtagaaag  tacctgtcc  ctttcttcc  780
ggagaaccc  cagtatcac  gaaggaagc  agataggag  aggaggaat  taagtttaa  840
ttcaaagta  tagatggaa  atctaaaat  gtatgctac  accacagag  tgaagaatg  900
attattttt  gcagcacta  accaaagaa  tgtgacttt  gtgattatt  ttaaaattt  960
atttggaga  aattgcaag  ttcgagata  gttgcttag  acaaaagac  cagattaac  1020
tctgtgttg  tgtctgtcc  accagctta  tgactttct  tttgtctat  ctccctgct  1080
tctttcgct  gtgtttaca  acattgaca  tcttttctg  gctattaca  cttgtgcat  1140
ccctatcaa  gcaccctgt  tattttact  tgtcctcct  agaaaagcn  agtcatttc  1200
ttaagtaac  aattattaa  ttcagaacc  aaaacattg  tacttttat  caatctatc  1260
ctcacatag  atttttttt  cacttgctc  gataatttc  cctttaagg  tccaacatg  1320
gatcacata  tgccttcag  tgagaaata  aattccttt  cagatattt  agaattgtt  1380
catggaaat  cttttacat  tccatctat  taacccatc  gttggtatc  gatagttga  1440
cttaactcc  atagagagc  agtgtgtgt  tgtgtgtct  tgttataca  atgtgcttg  1500
taccaaaac  atcctgtcc  tctgcaggt  acttagaaa  atggactag  accatggat  1560
tgtaagagc  tctaggagc  gccaggatg  accgcctta  agccacagc  gtcaccggc  1620
gcacacgct  tgtctgcag  tagctcttg  tgtgacctg  attgactct  aagtttcgc  1680
actgagctg  cttctttta  aagcatatc  tccagtttg  caaacggaa  aagtgtgtc  1740
gtctatcct  tgctatttc  ttctatgcc  ggagactgc  ggagcatcc  gagggggtt  1800
actatttct  ggtgtgacc  gacaatctg  ctttgatac  cattttagc  aatgtatat  1860
attaaatat  gcatataat  ctagagaag  aggccgttt  ccaaagttt  aatcccaaa  1920
caaatcaat  tctcattag  atacttcca  aatagagaa  atgtaaact  attccattt  1980
aataaagtt  gaaaagaga  atggatgct  gctctctct  ggtagaaca  gatgaccag  2040
agggaaaga  aatgggctg  tcttttcca  tgccaacaa  gcacatggc  taaccagtg  2100
gcaaaacaa  ttggtcagg  gaatgtcag  acacatcat  ccatctccc  attcctaaa  2160
actgggaca  ccatctcct  gcatgaggg  cttaaggga  tttgttgac  tcttttgaa  2220
atagtgagg  actcccatg  ggggtcatg  ctggggagg  cactgtggg  ctttccaca  2280
ggggcttaa  cacagttgt  cttgaagtt  accaggaca  ttgggaagc  aggatagag  2340
cagagggga  catctgtgg  ctgtagccc  caccatgct  cagccactg  ggactttgc  2400
gactctgct  ctgtgcagc  tcacttcct  ctgtctacc  ttccaccat  tgtacatgc  2460
cgggaaggg  tgaagtgat  cctgaggat  ttcatgtgc  tgcattgct  actctagcc  2520
ggtgtcctc  tgggcatga  tccactacc  aaaatatgc  caggatggg  tgacagcag  2580
taatccaag  ctggaccat  ctccatgcc  gcaataggc  agcacatgg  ggaaaacaa  2640
gaggaaagt  cttatagct  tcaccctgg  tcagggaaa  caacagttt  gtgagggaa  2700
acacagaca  gtctgagca  tggttttaa  aacaaaagg  aatcctgga  gaagagtgg  2760
aacaggaag  atggctgtc  tctcctaac  agtgtgaga  ctattcatt  tagaccaag  2820
agaaatgtt  caccttatc  tcatcacat  tatatatgc  tatcgcatt  tatattata  2880
gtatatgct  tatagatca  atatactta  atttatata  tatagatat  tgcttttaa  2940
cattaactt  aacatcaca  atttaaaat  cactttact  ctttcatct  ctgaattca  3000
aatataaat  tatataata  aaaatttaa  aattttaaa  tcaaaagga  gaaataaaa  3060
gaaggcctc  atataaact  acctaccat  cactgatga  cagggttga  attttagtc  3120
atacacagg  ctaatcttt  tatcttaaa  atgtgcaag  ttcaaaaca  caaaccccc  3180
tactacagg  aaagacatg  aactgtctt  catttagag  aatttgttt  tttttctgc  3240
gctgcctct  ggtgcctga  tgcggctct  gaactcgtg  aattctcat  agctcccac  3300
aacggaggc  ccaccctcc  ctcagcagt  tctataggc  aacactgca  aacgctgcg  3360
acataatgc  tttctagag  gctgcatag  gtgagaagc  cgccctttg  ctccaaggt  3420
ataatggct  tgctgactt  aattccttt  actgagcta  taaggacaa  tcgaaaatg  3480
cagagagaa  gagagcccc  taccccatg  tcccaaatg  aaaagcgag  gaacacaga  3540
atcccctta  acattaccc  ccaggcccc  tttgtgttg  tcttgccaa  acagcagcc  3600
tcctgctgt  tatatatca  ctgccactc  tgtccccat  acactcaac  ctgaccatt  3660
gctgtcaac  acgatggga  aggtgagcc  agggcgaac  ctccaggtc  gttgagtgc  3720
ccctctgtg  gggggatgc  gcttccggt  aaccatgtg  tgttacccc  tctccttta  3780
agatcacct  ctacgagga  cgaggcttc  agggccgct  ctatgagtg  agcagcgac  3840
gccccaacc  gcagaccta  ttcagccgc  gcaactcca  ccgcgtgga  agtggctgc  3900
ggatgctct  tgagcgacc  aactaccag  gctaccagt  cttcctgcg  cgcggggac  3960
accctgact  ccagcagtg  atgggtttc  gcgactcca  tcgctcctg  cgttccatt  4020
cctatgtga  tattgctgc  gccgtgctg  tgtgagaac  ctggtcttc  ttttggcca  4080
tttgttccc  tttctgttc  aatgttctc  gcaaagata  gaatgcttg  caaatgctc  4140
cactaaaac  aaggcccga  tcttacagc  aaatagaac  aacatgtat  cacacccga  4200
cagcagtat  agcaatata  agtttctta  ttaagggca  gagtgtttt  agacataag  4260
aacaacaac  ggaccttta  aactaaact  ggctgaata  gcacatacc  ttcagccat  4320
aaagaagga  atcctgtca  ttgtggtga  atggatgaa  ctggaggtc  ctgtgctaa  4380
aggaaggag  aaggtacgt  atgataaag  ccacaagtt  tcgttcgta  gtgggatct  4440
cagcagcag  ttcatggag  ggtgaagat  gggttgggg  tttacctca  cggtagtgt  4500
cctgtgtag  aagcacgca  ccctgaatt  tgttctgag  gtaaaaatg  gagagagag  4560
gggggggga  ggagaggga  agggagagg  agagggaga  ggagaggga  agggagaga  4620
agagagaga  agagagaga  agaaagaga  agagagaga  actagaggc  agagtggca  4680
agtcaggaa  cagaggttt  gaatgacag  cagaaaaag  aaaattaca  ctagagaga  4740
ctgtgttct  gaaatccgt  gtgaagcat  gcaatgaca  ttcatgtta  ctactagtt  4800
ttaaaatca  gaaaggtaa  gctggaaga  ggctcagtg  ttaggagca  tggctaccc  4860
tcttgagga  ctgggttca  ttccctgcg  ccacaagtg  ctcacaact  aggactcca  4920
tcctaggaa  tcccatgaa  tccaaaagg  caactcatg  agtacactt  caaacacac  4980
ggtaaatac  tacagacat  aaataaaaa  aaatacatc  taaacgcac  ataaaaaaa  5040
gccgaaaga  tggaatcta  gtattttca  cacaaaaat  atgtgagat  agaatatat  5100
tatattgca  aatcaatta  atttggtta  agctagtgt  ttcagattt  attggtgag  5160
tttttttat  ttactatac  ctctcacac  cacctagag  ctagaacaa  gtgtgtcaa  5220
tcgtgtggt  ttggttttt  ttaataagt  attactgac  agtctgtta  gaaacacgt  5280
attagaatt  catgagata  tgtctacat  acctgtctg  aaggaagga  aaagaaaga  5340
agaaagaaa  aaagaaaga  aggaagaaa  agagaaagg  aaaaagaaa  ggaaaagaa  5400
aagaaattt  tgtggactc  aagtaaatc  gaatcattg  acatcatgc  tacaaaagg  5460
agcttcgaa  taagcttag  aggatttgg  tccacgggc  gtaaatgct  tcactccct  5520
cctttcggt  ttcgtttcc  tcacaagag  tcactggtc  ggtcagctt  atgtgagtg  5580
atttcctaa  ctgttacaa  agcagcaca  ggagtaggc  taagggaga  gcacacttg  5640
cagattcgc  cgaaagccg  gttttgtga  tgtgcacag  ggctgtaac  ctgagtgca  5700
acatcgctg  ttctcctct  ctgtcttcc  cacaacaga  cagctctca  aggataagg  5760
tgtacgaga  agatgacta  cggggcctt  tgtctgagc  cacggaaga  tgttcctgc  5820
tccacgacc  cttccgcct  aacgagatc  actccatgc  tgtgctaga  ggcagctgg  5880
tcctctatg  gatgcccaa  taccgaggc  gccagtacc  gctcaggcc  ggagactac  5940
ggcgctacc  cgactgggg  gccatggat  ccaaagtcg  ctctctgag  cgggtcatg  6000
atttgtact  agccccatt  tgcttgtta  aacacacac  tgcaataaa  atacaactt  6060
tgttcctgg  actaagtgg  tctcgctta  cttcaatat  taaatccta  ttagtggtg  6120
cctagtaaa  ttaatgctg  aagaggttt  aaatgtcca  cctctgtcc  cacatcttc  6180
cttgcaaat  ttcattgca  tgagtcatt  tctggttca  ggcctctgg  ttctgtgac  6240
ccatcgtta  cagatcctc  ccagaactc  tcctggtta  cttgttgtt  tcctatgtc  6300
tggagatcc  gcagctttg  atcagcagg  ctgtttctt  cacacatcc  agccatttg  6360
agatgatat  cattttggg  tgggccaac  ctgagccct  gacctgggc  tggtcggca  6420
ctgagttgg  cagcctgcc  gctttccct  atttgtacc  caggacagg  caagctctc  6480
agcactgct  cggctaggc  acccaatcg  tgccattgg  agaggcagg  acctcctct  6540
tctgctctc  tgctctctc  ccctctgga  tgactcaat  ctgcctttg  catcaaggt  6600
agctccact  tgttgccca  tcaaggtac  tggcccgct  tcctgagtg  tacagacag  6660
gaagggaca  ggatagctc  cttattctc  tgatcccag  gccggctct  cccattgcc  6720
cagatggtg  ggggtgagg  ggaactggg  catcacccc  cacctatgc  acctcttgc  6780
cggccagcc  tcctgatct  acatcctca  ggctggttc  acaccccac  accagggtc  6840
acgctgcta  gctgtccag  caaggtaca  ggctcattt  ctgagtgct  aagctggtg  6900
ggggcagcg  tagctctcc  actcttatg  ccccagggc  atctcttcc  gctgcccca  6960
gtggtggga  catgagagg  taggtgttt  tgttttcga  tgaggcacg  tttctctgt  7020
tagccttgg  tgtccagga  gtcactatg  agaccaggt  aggcctcaa  ttcagagac  7080
cctccgcct  cgcctccgc  tccgcctcc  cctccgcct  cgcctccgc  tccgcctcc  7140
cctccgcct  cgcctccgc  tccgcctcc  cctccgcct  cgcctccgc  tccgcctcc  7200
cctctgggt  ctgggatta  aggtgtgag  caccaccac  tgttgataa  attcttaaa  7260
taaattaac  tttaatttt  attaaatcc  accaaagag  aaacaaaca  aagtgttgg  7320
gaggatgta  aaaagttgg  accctttta  attttcgac  ggaatgtaa  atgatgctc  7380
ttcgtagaa  tttgttatc  ctctaaaca  ttgccttag  gctagcaat  ccactatgg  7440
tgacacaag  ctgaaaaca  gggctcaaa  ggaaatcta  acatgaatt  catagtaat  7500
ctttcatgg  agctaaaag  cggacgcag  ccagtgtcc  gatgtcgat  gagttgcca  7560
acaaacaca  tgagaggtg  tatctggcc  tcagaggaa  gaggttctg  tcacgccat  7620
atagtgtac  aagaagact  acacagacc  cagacgaca  agacgacac  gatcacata  7680
gagtgcatc  agttatatg  agtgcccaa  actagaaag  gcattagtg  ctgcttagg  7740
ctgagggga  ggctaacta  ggttgtgat  tctggagta  agctttttg  tgaggcgat  7800
aacatatct  tacacacac  aaaaacact  aactatgaa  atagaacgg  atggccaaa  7860
ctgtctcaa  acactcccc  tctgattca  aaagcttct  aattgaagg  attctttct  7920
actgaaaga  catgtgggg  aaaatgaaa  tataaagct  aaaacactg  gactccaac  7980
agtatcaac  atggcagaa  aacctttgg  ttgctggga  cttggctaa  tcgctatcc  8040
acctgttag  gactaatga  ttacagctg  tgcattcga  tttcctttt  aacaaaaaa  8100
ggtaaaggc  tgggtcagg  ctcatggaa  acatctgtg  taacttgaa  tctcatctc  8160
ttttagtct  gaagaactg  acagtacag  aaactncct  ttcagttca  aaggcttaa  8220
gcattccct  ttttcattt  ccaaaataa  ggtgtggag  aggttcgcg  ccttcaagc  8280
cagacgtga  aaggccctg  aggtttcta  gtgagatgc  tctgtggtt  agtgcctcg  8340
tctggatcc  ataaacttg  tttcggact  tccaccttg  ggctgtgtg  gcttgagcg  8400
ggtctgtgt  ctccctagt  tcgattctg  actttcatg  tctcaggaa  attaaatgg  8460
actccgcct  tccacgcca  cagatcgta  aggctcaat  gataagcac  ctcacgcct  8520
tggtttgcc  ccattacac  cagacctta  ggtcatgtg  gcgctgtct  cagggaagt  8580
acgggagaa  aggagcaga  ggatgagct  tttcccaga  agtttctct  agtcaagtg  8640
atgtgaata  tctatttta  tttgccact  cgcctcaaa  accacaatc  tcctgcctc  8700
gcttctcag  tagctggaa  tctgggcat  tcctacctt  cctacagtg  tctgctgtt  8760
agcttcacc  cttactgct  tatcacatg  ctgtaccca  actaatgaa  cacccttct  8820
gttggtctt  ttaccaaac  agacgatat  aattggtct  atgccgtct  aacacacta  8880
cactccagt  atggccaaa  cacaccaag  ctggcagag  tgagtagac  atgtgggtg  8940
tagggcttg  agattcatt  ctgaagaag  gatctgcac  cctgagaag  tgacatcta  9000
agaggacaa  ccactagca  gtggaaagg  cattagttt  aaagcatta  gtcttgggg  9060
aaatagatg  gtttaatct  cattttctc  cttcactac  gtgcatgcc  ctctataac  9120
taagcaaac  tggagagac  gtgatgccc  aacctcgaa  tatactatc  gttgacata  9180
caaagatgt  aatggatat  acctctgac  agtatcaaa  tgttggcag  ctgtccctc  9240
gatcaaaac  tgagctggg  aattctggt  gctcagctt  gctctgacc  tggacttcc  9300
tctatgctg  tgcacagtg  gattgagcc  caaacctgc  ctctcagtt  ctgactccc  9360
tccagccgt  accaccctg  cccgcattc  tcatttatc  tgctaatca  tttagctgg  9420
gcctcctta  ccttgccgt  tcctcttag  aattctctg  ccagtgtcc  gcttattga  9480
caccaacct  cttgtacat  tgtatggag  cangctaat  cctgctcat  acaaaaccc  9540
cacacatag  tattcctct  acccgcttt  nctatacct  ttgctaaat  gtcttgcca  9600
cattagcag  tagtangac  aatttttct  ccataatga  ttgtttgct  ttaactgat  9660
tagttcntt  tccactcct  attgctttt  gcntgtact  taaaactca  tatgttctt  9720
gattttcat  aattactct  accttataa  tgaggaaac  gaggattga  aggttaaat  9780
agtctccag  gattaaaga  gcattacca  aaattgcta  atatgtgtg  atgtatgta  9840
gcatggttc  cctacacat  ttctccatg  attgtgact  ttcagaagt  cctctgtgt  9900
aaaaaacaa  gttttaaag  aagcaatgt  aaaataaag  attacacag  aggaaagtc  9960
ttccacagt  ttgtttgca  acactggat  ttctaagtc  gtggtcatc  agccctgag  10020
gcatcattt  tgcccaggt  tctgatgct  ccagtttag  aattgtgag  agaagccac  10080
gattacagg  ccagacatt  tcataattc  tcacttatc  gaagaggct  actctcacc  10140
ctgaatcag  attttattt  taggtatct  atttaatcg  caacatgtc  taatacatt  10200
tttgcttca  gaatgcttt  ggactgcca  tntttggtc  agatgttgg  gcaaattct  10260
cagcatcac  tggtgcaag  taaggagta  gcaggatgc  caaatataa  tacctcgat  10320
ctttttcat  tgtaacaaa  tacctgata  aaatacctc  gggaagcaa  gattcattt  10380
gctcacaat  tcggaggat  atcacctga  atggtgagg  aggataatg  ccggagaga  10440
caagccatg  ctgccgatt  catatggta  cccaccggg  gacagaaaa  ttgggctgg  10500
aagagaaga  ataatacaa  acatgcccc  ctgactgac  tattttttt  taattaggt  10560
ccatttgct  aaggttcca  agcctgata  acaaaacac  atatgagga  aaagtcctc  10620
aaacatggg  ctgtggaga  tataacaca  tcaatatgt  catgacccc  caaagagtg  10680
taacaagac  aggatataa  ctcttgctt  ttaagatct  ctatcacca  cccttttta  10740
tagggtggc  taggttacc  cgaaagctg  ttggaccaa  aatgctaac  gtgacaggg  10800
ttatctcga  acactctgt  ccctgggca  tttggagct  cctgaatcc  tcatgccca  10860
aggatatta  attcccttg  tcctgccag  aaaataaac  tttgatcac  tgtgaaatg  10920
agagccaac  gccacttct  agagatcat  gttaccaca  gaaatcctt  cattataac  10980
ggcatccat  tggctatta  aagatggac  ctttgattt  tgtgctcta  gcaccaaac  11040
gactgtaag  gatcctcta  tgccacaga  acggaaccg  gggagcatg  tgctctctt  11100
cccttctaa  cttcatcac  gctggacag  tccagtgga  gaaactgta  tgtctaact  11160
catccactt  ggagctccc  gaagactgc  tcttcattc  ggatcctgt  ctctcaggg  11220
actgtcttc  tcccccaga  cacagaagc  ctggacctg  tctgagatg  ccttctgca  11280
aggagagag  atatcctcg  agctctaaa  gaaacaagc  tccattatt  aagagggga  11340
acggcaaat  cacaaggag  tacagctga  actgagaca  gtgcaaggc  cgggtccta  11400
tggacctgg  ccctttcta  actcctgtt  ctttgtctt  atttatttt  ctttttgga  11460
tttcatacc  catttactc  ttatttctg  gtaagcatt  atactcatg  gtaggtcag  11520
gaagaactt  agggaatta  tcctctcct  ccaccacat  ggacccagg  atctatcag  11580
ttttcaggc  ggataacaa  aagagcctt  cccactgat  tgtcttgct  agccctgat  11640
tattgttct  tcctaagat  attgacctc  ctgtgcatc  gaaccagat  actttgtca  11700
gcatggtga  gcagatctg  agtcccagt  ccaggaggc  gaagcttga  aaacacaaa  11760
aatttgagg  cagccttgg  tacatagta  gtcctgtct  aaagtgtgt  aggtgtgta  11820
gggagaaca  agaggttrg  tgaggctta  taaaaaaca  aggtttata  aaaatatac  11880
gaaacctac  gctttataa  ctaacttta  aaaacaatt  taaagatgt  ttattttaa  11940
tatatgggg  gagtgtggc  tgcgtaaga  tcagaggag  gtataggac  cctcaaagc  12000
ggcgccaac  gtagctgaa  gctctggac  cagacactg  gtcttctat  agaacagta  12060
gtgctttta  ttaccaagc  atttctcca  tccccctgc  ccccgccca  tataaagga  12120
agctctaag  ggctgaata  tgctcctcc  agaagcatt  ggttttaaa  gaaaatccc  12180
gtgctggat  tgggatact  tcctatgag  attaccagg  agatccaaa  tgttagaga  12240
tcttcccac  gcttttggt  gtctgccaa  actagatga  gaaacttca  tgctgcaga  12300
actaaacac  ttggacaca  gacctagag  aaccaagtt  gaactaagc  agaggcctt  12360
tctctgcta  ctagtgttc  gtgtgtcaa  ggttatgca  gggaaaagt  atcaatgtt  12420
ttttccagc  acgggctct  aatgctaca  taccaatat  ccagacaag  tatggctac  12480
gtgggcata  ccaactgct  cctggttgt  tttcaaacc  tcttcatgg  aggaaatat  12540
tattcttgc  attttaact  tggccaaaa  tctatggct  gagacgtcg  cacaggccc  12600
ggtggggaa  gtagtacta  tgttgtttt  ttaaacgga  gtgtagtca  actgccttc  12660
aaatgttta  gattctagc  atacgttag  gtggctttc  ggtgcggtt  gagaatctc  12720
ctctctctc  ctctctctc  ctctctctc  ctctctctc  ctctccaaa  agggtgatg  12780
ttaatacag  gactaatta  tggtgagag  attgaaaat  aatgaatat  aaaatactc  12840
gccttaagt  ggacattgg  aatattccc  gcaaaacct  gcataagaa  aggtagaaa  12900
attgcaatg  ttaagatct  agaggagtg  tatgcaatg  tgttttctg  atttggcat  12960
gccattgga  tcatgggca  atagctacc  tcacaagaa  catacacct  tacataaca  13020
acacacaca  acacacaca  acacacaca  acgcacgca  gcacgcacg  acgcatgca  13080
gcacacaca  acaaatcct  aatgtagga  ggggacccg  cttggaaga  aggagtcag  13140
aggatctta  attgtcgta  atggaatat  aaatgttct  cctttctcc  gcctcatga  13200
ttgaatctt  gccctcagc  gatggccct  cttgaagag  gattggaaa  catgagaga  13260
aaagtctag  ctgggggtc  ggggaggag  ggggtcaag  cagggagtt  ggagtgtct  13320
tgaaggtta  gcttggctt  acccctttc  cctgcttcc  gtctgccct  atgtgaaga  13380
ctcctcctc  ccacacacc  acggatgtt  cgacttacc  caggccaaa  acaatagag  13440
cagggctgt  gaatcccaa  accaaggac  gaaaatgag  ctttctccc  tcctttgtg  13500
cacattgtt  tggtacagt  caccgcctg  ctagtatat  cttcactta  acatcagac  13560
gtcaacgaa  acaggggtg  tttaagtca  attaatgct  actcactga  gtttcgttc  13620
catcctaca  cgagtgaca  tgaatatat  gagttatat  taaaataaa  ttgtggggc  13680
tggagagac  actcagcag  tgagaacac  tcctgaggt  ctcaattcc  agcaaccac  13740
tggtggctc  caaccatct  taatgggat  tgatgcccc  ttctggtgt  tctgaaaac  13800
gtgacatgt  ctcacatac  ttaaaaaat  ataaataaa  attaaaata  aataaagtt  13860
tgactttcc  cctttcaag  gttagaaat  ttagcacat  aaaatgaca  tgtttttca  13920
tgagtcctg  cgggtgaac  tgagtactg  agaagctta  tcaagatat  ggtcctgcc  13980
aggttggag  ccccagtgt  agggaatgt  ggggagagg  ggtggatgg  gaggggaac  14040
gccttatgg  aggggaggg  gatgggata  ggggtttat  tccaggaaa  tcggaaagg  14100
aataacatt  gaaatgaaa  ttaaaaaag  atccaataa  aataaaaag  tatggttaa  14160
agtccggct  gatcattac  ttttctcca  tgaaatagt  actgtttat  aaaaggcta  14220
taggatcac  ttagctggt  ttactgttc  ctttattta  gagggctca  gatggatgg  14280
atgtgtgca  cacactata  caataggga  tgggcttta  atgccttga  gcctggaaa  14340
cagatacca  tgcattacc  tagctggtg  gatcaggac  agtgcttct  agcgtgagc  14400
ctgtggtcc  ctgtcacac  atcactcag  accaaggtg  tccgtccca  agacactga  14460
agctcgaaa  tcagtgcaa  gagcctcca  aacgtccgt  agccaaagg  agctgctga  14520
cgtacctta  cctacattg  ctctctcca  ggtggcaac  tacatcgat  tactgagca  14580
taaaggggc  cgaagtccc  gccccttgt  cagtccatg  ttgctctag  ttccctgag  14640
aagtcacca  cattttatt  tctcacaat  ctaatggca  gcaggagac  ctgtggaaa  14700
gagatggac  agctcagtt  actaatgac  tggcttgat  tatgggttc  agccaaaag  14760
agtgttatt  catgatgag  cctgtggta  gtttgaata  gcttgccca  gagggtgca  14820
tattaggag  tttggcctt  ttggagtaa  tatggcctt  tgggaggan  gtgtgtcac  14880
gtcggaggt  tgagaccct  ctcctgnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  14940
nnnnnnnnn  gcttacagg  tcagaggtt  agtccacta  tatcaaggt  gtgtatggc  15000
gtatccagg  aggcatggt  caggaggaa  tgagggttc  acattttca  ctgaagggc  15060
nnaggagaa  cctggcttc  tcaggcagc  aagaggaag  tctcaacgc  cacactcac  15120
gtgacacac  tcctccaat  agaccacac  tccaaatag  gccatcctg  gccaagcat  15180
tttcaacca  cacagccag  cttctcctg  ctgcctttg  atcaagata  aaaactttt  15240
ctcctccag  cccaggtct  cctggacat  gccatcttc  tgacatgat  ataatggac  15300
gaacctctg  agctgtaag  cagcaccaa  caactgctg  ctcttcaca  cagtggaaa  15360
cttaactaa  ataccacct  actcaggtg  cccccaaaa  tgcagtgaa  gtagtcctc  15420
cagggggaa  ccttaaaga  gtgagtgtt  tgctggaga  atggctcag  ggttagaag  15480
acttgctgt  cttgcagat  acttgggtt  gattttcgg  acccacatg  cagctcatg  15540
ccatctgta  ctgcagtcc  aaaggatcc  aagccctct  ttgatccct  taggcaaaa  15600
gtatgcata  ggtatgcat  cgtatctgc  ggcaaacac  cataaaata  taaaatgaa  15660
aactattta  aatacttgt  tttttttct  gaaaacaac  aaaaaccct  aacccaaaa  15720
ctgacaaag  aaataactt  aaaatattt  atttattta  ttttttctt  aaacaaaac  15780
aaacaaagc  agctggtca  tcacccact  tgtgtgtga  cccagggct  aaaaggagt  15840
actgagcgt  gtgagtcac  tggctagtt  attcggggc  aagaaaggg  gagatctgg  15900
gtaagaagg  ctggggtag  ggtacatgc  tggagctac  gacatagct  cacagtatg  15960
ccctgccac  cactgctgc  tctcacagt  cttccacaa  gagaaaatg  taaaccacc  16020
aagcaagtg  cagaactat  ggaacaaag  actcaaaaa  gtcacatcc  tggcagctc  16080
ggggaaggc  gtgctaact  ctcccgaca  cattaattc  gccattacc  ttatgcatc  16140
tcctgtcca  ctgaaaggc  gaagagtca  gcaccttag  gtgctctct  cttttgagg  16200
agtccacca  cctcttggt  gtaacttga  tacctaggt  ctttccatt  acccttgct  16260
gcatccaca  acatctcac  ggtatttgt  gcctgaagg  tagacagta  acttatatg  16320
taaataaat  gtatatgct  gtgagtaat  accatattt  cccaaagac  acgaaaaga  16380
gcattgttt  gcacttctg  aaatcctta  tttgtgaaa  tgtcagtac  catttgtga  16440
agaatcata  tttcttaaa  tagcaaata  actcagcac  gccctgaaa  ctgtcactt  16500
acgtcgacc  ggggccccc  tggttccca  aactacatg  ataaggcac  ctgtcaagg  16560
accctccac  ctcctccca  cccccactc  acccaccct  cacgctcca  ctcccatgc  16620
caaatcttg  cggtatgta  ccattatcc  aagtctgag  aagttagtg  tgggtgcta  16680
gaaagtttc  gtctggatc  tggacaggn  atcagcaga  gnaagattt  aaagtggag  16740
agcataaga  tagctgttc  tttccccca  tcagggcca  aacaaggtc  tcatgtgca  16800
tgaaactct  ttctaggtg  aagggtgga  aagagacat  acaaactgc  gctaacaat  16860
gtttcagac  gtcccccag  aaacattaa  aatcataga  tcttgaatt  gaactaaac  16920
ttatgcttt  cagaatatt  cctcagatt  aatctccct  actctctct  actcgagat  16980
ccttactgt  taagttttc  ctttaaaaa  aagtttaaa  catacaacc  aaatccgaa  17040
cacgtgcag  tgctaaatc  gatttgctt  gagaagtcc  ttaagccga  taagctata  17100
agtaaacgc  tagaattag  gcttcgcgt  cttttgcaa  acaagagca  agacttttc  17160
cattggtag  aacaacaca  cagctttag  gaattagag  aacccgaac  taccagaaa  17220
aatgagagt  aaccattca  ccaactcca  tgagcagag  gagggagag  gctctccga  17280
cttgcaaat  cccttactc  ctggaatgg  cccttttgt  tgatttcct  tggaggcag  17340
agtcatgac  gctatatat  ccagaggcg  tcccctaga  cctcacagc  cccagggca  17400
ctcttacta  cagcgagat  ggaaaggta  gtcccggaa  cctgacctt  gccctcaag  17460
agcatcctt  ctggcagaa  tcaattatt  gtctggtcc  ctctgccct  acagatcac  17520
ttcttcgag  accgaggct  ccagggccg  tgctatgag  gcagcagcg  ctgccccaa  17580
ctgcagacc  acttcagcc  ctgcaactc  gtccgcgtg  acagtggct  ctggatgct  17640
tatgagcga  ccaactacc  gggccacca  tacttcctg  gacgcgggg  ctaccctga  17700
taccagcag  ggatgggtt  cagcgactc  attcgctcc  gccgcctca  cccccaagt  17760
agtttggct  tgtcctcat  attggtctc  ggaaacaca  attaccttt  aaaaaatca  17820
cttaaacca  gtcgtttca  ttagagcag  gagtgggtc  gacagtatg  gtgttcagt  17880
gtatatcat  tctcaggaa  gtggtgttg  gtttcttag  aaactcaca  ccacctttt  17940
atatttata  gccatcaag  attcaaaca  cagagagta  ttttaaaaa  aggatatcg  18000
agacagtgc  tttatcatt  gcttaacat  taaattccc  gcatatata  agtccttag  18060
tcattccaa  ccacttcta  tcagaaatt  aatgtttct  aatctaaaa  tataatgta  18120
tactatgtc  gtgttttaa  atgcgttgg  tgggtagga  atgctgaag  gatagcagc  18180
agagttcaa  gccagcctg  gctacccac  ttgtatagt  cagaccacc  tgatctcat  18240
taaaaacgt  ttgccttgc  tggccttgc  tttctttct  cttgctttt  ccaccttct  18300
cttttcatt  atttgtagt  gacagtgcc  atgggctcg  ttggaggaa  accccagcg  18360
aaaggccag  tctaaagct  aagtcccag  ctcatgctt  ctggagatg  ccataggta  18420
catcctagg  aggtagagt  tgggagaca  gagacacag  gccacggaa  ctataggaa  18480
gtaacttca  catggagag  tgcccctga  aggaagggt  agcctacag  gaggaagca  18540
ggaaaagcc  atttgaacc  aaactgagg  ttggaaaga  aaagaagga  acacagcac  18600
taatttatc  caggggctc  gccttctga  ttgtagata  gtgaaccaa  acacttcgt  18660
tgcagaaaa  aatcgctga  ggttgatac  ttgtcaaca  gggagataa  tcaaaatgc  18720
accttcctg  taactttta  atttcctcc  ctgcaaagg  ctgtctcag  actgagatg  18780
tatgggttt  attttttaa  tatttttag  ttaagtgtg  tgatcttta  tttaagcaa  18840
ttttaattg  cagggactt  tggatgggt  ggtaggcat  gagagcgct  agggctgtt  18900
ctcaattgg  cattgacac  ctagagtct  caagagaca  cccaagctt  aggaataga  18960
acttccgta  tctgtaaca  gcttgtcct  aacgcaaac  tggacttgg  attttgagg  19020
tggaggtgt  gggacagga  acatctttg  gctcatttg  ttttcttct  ctgtctgcc  19080
ccaccctca  tcccccacc  cagcactcg  gcacttaca  aatgaggat  tacgaaaga  19140
atgacttca  aggacaaat  tcagagatc  cagacgact  tctctctct  caggatcgc  19200
tccacctca  cgagattca  tccctcaat  taatggagg  ctgctgggt  ctctatgag  19260
tgcctagct  cagagggcg  cagtacctg  tgaggccgg  agagtacag  agatatctt  19320
actgggggg  tgcaaacgc  aaagttggc  cttttagaa  agtcatgga  ttttactga  19380
gcattttga  actctactt  tctcctcta  aaactaata  aatatgtag  ttatgattc  19440
ggcaccaca  gagtcctgc  tttctttta  tctcttaag  agagatggg  aggaacttc  19500
tatacgggg  aatagcatt  tgggtattc  aatgactac  tatgtaagg  taaggacct  19560
aagtttaag  tatcaagaa  agtcacagc  ggcctggtg  caggattta  caggtaaag  19620
tgcctgtcc  aagtctgag  gtcccatgt  tgatcccca  gaccctcac  gaaggagag  19680
gtcaattct  ccaagattg  ttttttgat  gaccgcctc  ccccaaccc  cccacaaat  19740
aataaaaat  caatggaaa  aaaattaag  ataagccaa  ccatgacca  tactaaaac  19800
tggtttttc  tacgggtcc  agaaaagag  taactgagt  aaatgtgac  aaaatgacc  19860
gcatttagt  aatgaagtt  cagggctgt  tcttgtaag  ctcataaaa  aagtctgat  19920
agtttaggt  aaaatgcat  agattgccc  atcctttga  aggttaata  gttggctca  19980
atgtcttgc  tggagtggg  actttatac  accaccctt  cctacacag  catgaccgg  20040
aaaaggatt  tgtggccca  cgtcgccct  gcccagagt  tcctgcctc  acactggat  20100
ggcgctcac  ctctcccac  agtgctgat  ttcccatgg  ccaccctga  ccagatgga  20160
aactcgttc  ccaatgacc  ctgacccag  tctcacatg  ggcttcaat  cacacaact  20220
tttttgtta  agaggttcc  gggtatgag  gnaagctta  aataaagca  ggctaatta  20280
agaaattta  cgctagatg  cccctgctt  tgagggtgt  gctcaacag  gagcattta  20340
ttaacatga  taaggccat  aatgcaacc  cgaatatta  aaaaagcaa  aagtacttt  20400
ttcgatggc  tgtggtctg  aggtattag  aggcctgcc  cctttccgt  cttgttccc  20460
tcatcgtgg  acttatctg  gtacacagg  agctacttt  ttttgggac  cctgtcatt  20520
catatcttt  gaaacttca  gttcaatac  taagcactg  atagataca  taagcatat  20580
atcggcaca  aaaatttgt  tactttaga  agttaagga  cttcctatt  ataatcttc  20640
ataattctg  tcaaagaac  gttctgaga  aactggggc  tacaattat  aattttatg  20700
gaatacata  ttagtcagt  aatacctta  aaaatgttg  catataaat  ttaacccta  20760
ttctttaac  tttaactcc  aacatcagt  tatctgtta  aatccactc  gggatatat  20820
caagtctct  ttcaccacc  ctaacacac  aagcatgag  gaggatggc  gaagaggct  20880
gcctgttat  ttcccacta  ttgcttggg  ggcagaaag  ttgcacctg  gccaacgaa  20940
ttattagta  atacctcga  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  21000
nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  agatctgcc  21060
gcctttgct  ccaagtgct  gggtcaaag  tgtggaccg  tatgatcat  atccctgca  21120
ctttctctt  gagtcattg  tcgtgaaaa  tctctgctc  cttctgtgg  atacagaaa  21180
agagatagg  gttctcaca  aacaaaaag  aaaggtcac  aatggagaa  ggcttaggg  21240
aggactata  ccaaactaa  aactactac  actacttct  cacttcctc  cgtcctccc  21300
ctcctcttc  tccttcttt  atttttttt  ttttttttg  gatagggtt  ctctatata  21360
tcttggctg  cccagaact  actctgtag  tcagactgg  ttgactcat  aagtcatgt  21420
tatattcca  ccagaggga  taaaggtgt  tcattccag  cagatcaca  agacctaga  21480
ggnctttgg  cgtgatccc  tgccagagc  gccatgtta  tggataaat  ccttgacag  21540
ttgttttnt  tctgctttt  agtaggctg  gagtggctg  gtncacagt  tggnnatgt  21600
acagttaat  atagtctaa  gtttagcca  nctgactgt  nncacccnn  nnnggctng  21660
acagcacnn  agaggtggg  ttttggttc  ctctggann  nnnnnnnnn  nnnnnnnnn  21720
nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  21780
nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  21840
nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  21900
nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  21960
nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  22020
nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  22080
nnnnnnnnn  nnnnnnnnn  tactgataa  tatacatgc  cctgcaaac  nnccctnac  22140
catgcttct  taaacaccc  aatgcaact  atggagtca  agtgaacaa  acacacaga  22200
agaagaaag  attggtgtc  gagttttat  gccacaaag  aacattatg  ccatggcac  22260
tcttataaa  gaaaacatt  cattggagc  ggcttacac  ttcagaggt  cggtccatt  22320
ttgtcctga  gggaagcat  gcagcatgc  ggcagacac  gtgctggag  cagagctga  22380
agttctaca  cttgatctg  aggcagcag  aagaaactg  gggccacac  gggcataac  22440
tgagtatat  agacctcaa  gccccccaa  agtgacaca  ctccttcaa  aaggtcatg  22500
ctcctaata  tgccattcc  tatagccac  tgcatctgt  agggttttc  tattcaaac  22560
accacagtt  gggagacta  ttaagaaag  gagtagtaa  agtgtgagg  agataagag  22620
gtaaggcgg  gagtatgat  aaaatagaa  acggggctg  ggatttagc  cagtggtag  22680
gcgcttacc  aggaagcgc  aggccctgg  ttcggtccc  agctccaaa  aaaagaacc  22740
aaaaaaaaa  atagaatat  tacacatgt  aaagagtta  agtgaaatc  atctgaaag  22800
attagcaat  ctagttaaa  taataaaga  aatcttttt  ttttttttg  ttctttttt  22860
cggagctgg  gaccgagaa  cttaataag  tgtgagcaa  accttatct  tgaagtttt  22920
aaagaaaaa  aaaggaatg  gccaggtaa  ttggtacag  ccataattc  agcacttgg  22980
aagatgaga  aggaagatc  cgagttcga  gccagtcca  accacatat  aaatttaaa  23040
ctgaccttg  ctatacaga  agactttgc  tagcgtgtc  tatacagag  taaagctag  23100
cgcaaacca  taaactgag  atgggaccc  attggagaa  ttagagaaa  gattgaagg  23160
gctnnggtg  aaccccata  gcataacaa  gtcaaccaa  cagagctcn  agggactaa  23220
ccattatcc  aagactata  atggacaga  ccagggctc  agctgcata  gtagcagag  23280
atagccttg  tgggcacca  tggaagaag  tcttggtgc  atcaaggtt  gacccccag  23340
gtaggggaa  gtcaggggg  ggggaatag  gagggaggg  tggataggg  ggggaacac  23400
cttatagaa  aagggaggg  tggaatagg  gnnntatgt  caggaaact  ggaaaggga  23460
taacatttg  aatgtaaat  aagaaataa  caataaaaa  aagaaagac  ttgtattaa  23520
gcaaatttt  gaaagtttt  tttgggggg  gggggttga  acagggtat  tccgtgtat  23580
cctagctgt  ctggatttc  ttctgtaga  caggctagt  tcaaactca  agagatttg  23640
ctgcctatg  ctcccaagt  tgggattaa  ggtgtgcac  atcactatc  taaaacaat  23700
tttaaatcg  aactgaaga  ttacaagaa  ctgaaggat  tatttgtta  taattttag  23760
tagcatatc  cagaatgga  ttcattgtg  cattttcac  ccagtttat  attgcacca  23820
tgtacttat  tcatattta  ccctgactt  acctatatc  gtcctaccc  cccctactg  23880
tcccctttt  ttaccacgt  agattattt  agaaataaa  tttccctat  cgagagtag  23940
gtatgatat  tatctttgt  agtctgtaa  ttttattta  tacaaagat  tctggttcc  24000
tccatttct  tgcaagcaa  attcatttc  ttcttcctt  cttaagtag  cattgccac  24060
ttttcttca  tcattcatc  cctaagggg  gttcaaact  cttccacta  tttggctac  24120
gtgaacagt  ctgagagac  cacaggtga  caggttgtt  ctcactgac  ggatcttca  24180
agtttagtc  aagaattat  tagtcctgg  taaaacatg  agatgctaa  attcttgtc  24240
tcatttaat  aggtagaat  ttcttaggg  ccagaaata  gtattttta  aagcactgt  24300
attattaca  acagtagtt  ataaactaa  aagattatt  cttcttctt  ttcttcttc  24360
tcttcttct  cttcttctt  ttcttcttc  tcttcttct  cttctcctt  tccttctcc  24420
tctccttct  cttctcctt  tccttctcc  tctccttct  ctccttctc  ttcttcttt  24480
cctcctcct  cttcttttc  tccttctcc  cctcctcct  tttctcctt  ttcttcttc  24540
ttttgtctt  tttttcttc  ttgagacag  tctctctac  tagctctgg  tgcctggaa  24600
tcaccatgt  gtccaagct  gcctttaat  cacagagat  catcttcct  tgccaagtt  24660
aggggatta  aggcatgca  tgccactcc  agcccccct  acaagattc  taatgttta  24720
tctaaatct  atctttttt  tttttaacc  caaaatagc  ctatagaag  gaaggtttc  24780
ggaaccttt  gagaacact  aacctttgg  caggaagca  gctgacatc  tccttaata  24840
tgtcactct  atgctactg  caatgtcat  aatattacc  gtgttcatc  gcaccaagt  24900
gtgtgccaa  aatggtata  atgtagtct  gttaaggaa  gctaatgtc  attagctaa  24960
catctctag  aactgccta  ctgtaagca  attaagttt  agacttgct  cttccaggg  25020
aaacacata  cctgaggaa  tggggatgt  ttccaatag  tgactttag  agagctgtg  25080
ctcgaatgt  taccttgct  gtgtggttt  agagaggtc  aaaacagtg  aggtctggg  25140
ggagaagcc  atgtatgaa  aaggtcttg  gttcaatcc  taccactgc  atacacagg  25200
agagagaga  aggagtaga  gtgaaaggg  gaggaaagg  gggagagag  gaagaaaga  25260
aacaagaga  aaaaaaagc  cagaaattt  ccagagttg  ctatgcaca  ctgtaatca  25320
agaaccgaa  tggctgagg  aggaggact  cagtatgtt  agggcttgc  taatgagac  25380
ctagggngc  ggggctggg  gtgggggac  aaactgtaa  taaagaagt  acagtgtaa  25440
agtttggtg  tgggcttgg  gggtggtgt  atatgtgtg  gtgtgtgtg  gtgtgtggt  25500
tgtatggat  tgtgtgtga  gtatgtgtg  gcttgtgtg  gtgtgtggt  tgtgtatat  25560
tgtgtatgt  tgtgatgtg  atggatgtg  gggtgtgat  tatgtgtgt  tgttgtgtg  25620
atgtgatat  tgtgagtgt  tgtggtgtg  acgtgatgt  tgtgagtgt  tgtgtgtaa  25680
tgtgtgtgt  tgagtgtgt  tgtatgtgt  tttattagc  aggctctgc  ggcatctat  25740
agacattgt  tttgataaa  aaatagcta  aaagtattt  aaagtgacg  ttagtcatt  25800
gggcccaca  ggacagtac  gtgctcagc  gcctctggg  ggctgtagg  ttgtctttg  25860
tcaaacaaa  tcactttga  taaccttgt  tgaggggac  tattaagac  tgtttatat  25920
taacagctg  atagcaggt  ctaggcaga  gcgctggat  aggtgactc  gacacagga  25980
gtatacgtc  tccctggcc  tggaagcaa  taattctac  ttcgtacat  tttgacggt  26040
ttgggcctc  caaccatag  aattttttc  tttgttctt  actcaagct  gttaccagg  26100
acggatttt  actcacgta  tgtgaaacc  ccaaggtgg  agctagctt  ggtcctaga  26160
tatcagctc  acatagcct  gaaaagcca  gatccaaat  taggtttgt  tcctgtact  26220
aacaagcaa  ccctgtaaa  aaaagcagg  ggaagagga  taagatcgc  tggtctctg  26280
tgcactagt  gctgcagta  tcgaagaat  ccagcattc  caattctgg  gatacttct  26340
cgaatgcgc  gattcctcc  agatttacc  agtataatg  aatcaaaat  tagggacgt  26400
gacttcagg  caaaagttc  ggctgatgt  ctgataaat  taaaaaacg  taagaatcg  26460
aataaagca  ctctgacca  ctagctcat  cagggcagc  ttggaacac  ctagagaac  26520
aggcgaatc  acagtcacc  ccactgaat  cagcccgta  aagccatcc  tgaaattcc  26580
tcagcccgg  gggcccctt  tgtgcagtt  cgctaacac  gcaacaacc  tcctgctat  26640
tagaccggc  ccgctctgc  tggacactg  actcaccac  ggtcagcca  ccatgggga  26700
ggtgagcag  acgcaaact  aacgaaaag  cagactgaa  cgccttgac  caaggagca  26760
aagatctca  tcagaattg  tcttccttt  cagatcacc  tctacgagg  ccgaggctt  26820
cagggccgc  gctatgagt  cagcagcga  tgccccaac  tgcagacct  cttcagccg  26880
tgcaactcc  tccgcgtgg  cagtggctg  tggatgctc  atgagcgcc  caactacca  26940
ggccaccag  acttcctgc  acgcgggga  taccctgac  accagcagt  gatgggttt  27000
agcgactcc  ttcgctcct  ccgcctcat  ccccatgtg  gtcctgttt  atttcattt  27060
ttgctgccg  ggggtcctc  ctgttttac  gatccagag  atagggttt  tttgtctgt  27120
tgtctgtct  tctgtctgt  tgtctgtct  tctgtttgt  tgtttgttt  ttctgagta  27180
ctaagtgtt  agtggtcct  aaatgcctg  ctaagtcta  gagaataca  gcaggaaaa  27240
agaattata  ggaagaatc  actttcaga  ggtccagtt  ttttttgtt  tgttttttt  27300
ttaattttc  ttgctacca  tagattaat  aaaagttgt  ccaacgaat  taatcttat  27360
cagggatat  aaacaaaac  agttgggaa  gagagggta  ttacactca  cagattgat  27420
tttatgtat  taataaagg  attcctggt  agggagtta  ttaaacttt  ttgtggagt  27480
gaaaacatt  aaaagtacg  agatcagaa  ctgtacggg  agaactcaa  tgataattt  27540
ccttagttt  gaagatcgg  tcagttctc  ttataagcg  ttatttaaa  taactttcc  27600
cagaagtgt  tgatttttc  gaactccac  ttagccagg  atagtgata  cctggattc  27660
tagggtcca  gaagctgag  caaaagtat  ttaagtttg  tggtaatct  ggttataaa  27720
taaacagaa  gggacagat  gaaatgata  gaaattctc  aaaaacaaa  atatatata  27780
gtaaaaaat  ctattttat  tataaaaat  atatatttt  atgtataaa  atatatata  27840
ctaaaaaaa  actagttaa  atatgtatt  gtataccct  caacataca  cttagaatg  27900
atataagaa  ttgtgaatt  agatatttt  atttttgat  tgctcaaat  cacttgtaa  27960
atcttataa  tcccacctc  tagatcagt  ggttctcaa  tctcctaat  ccacaaccg  28020
ttaaaaaag  tccttatgt  gtggtgacc  catgccata  aattccttt  gttgctact  28080
cctaactgt  attttgcta  tgtcgcgta  cataatata  atacccgtg  tttccgatg  28140
tcttaagcc  tcactgtaa  caggtcatt  gacctatag  ttgagaacc  ctgttctaa  28200
tgaaaagaa  cctgggcgt  tctaatgcg  gcaggagac  catccatga  tagctctcc  28260
aaatccgtc  ggctcagat  ttactccaa  agccccctg  ctcacccgt  gtttagctt  28320
ggtgagttc  ggaagagac  caactgctc  tttctcatc  ttctttgtg  gacccaagc  28380
gacaggttc  cacaggatg  gtctgtatg  gaaagaaga  cacaaaggc  tcatgatgg  28440
gctgagtga  gactgctcc  gcatccagg  ccgcttcca  ctcagtgag  tgcgctcgc  28500
gcacgtgct  gagggctgc  gggtcctct  tgagatgcc  aactaccga  gccggcagt  28560
tctgctgag  cctcaagag  accggcgct  ccacgactg  ggcgctgta  atgctaagg  28620
aggctcttt  cggagggtg  tagatttat  ctaaaatag  tgaacgcta  cattttctc  28680
ttttggaac  taataaagt  tttagtctg  attgttggc  aaccttgac  tctgttatt  28740
tttcattgt  tgcaaatac  tccacctgt  aactctccc  acagaaggt  gagctgaga  28800
tggagaggt  agggtgttc  agaactttt  aatggtgtt  actttgaac  agtcttaga  28860
ggctgggga  ctatgtatg  gtctcagtg  tagagcttt  attcagtgt  cacaaggtc  28920
tgggctcga  ccctaacac  accagaaag  aaagaaaaa  gttcaggtg  agggagact  28980
tacctggtg  ggtagggag  gtacaccac  tgggggagg  tgtactgtg  tggggaggg  29040
acaccatgt  ggggagggt  taccatgtg  gggaggtta  accatgtgg  ggagggtac  29100
ccatgtggg  gagggtata  tgtgttggg  aaggtatac  atggtagga  ggtatagct  29160
ccggacaat  aaaggccag  tcaagctga  gacacggca  caagacaaa  taccaggga  29220
gaagtagtt  tctgacaac  ttgaagaac  acacagtca  agttgtctt  taatcctgg  29280
agtgattgg  gtccaatgt  gacaaacag  ctatcaaga  tcataagag  actaatttc  29340
tttactata  aacacaata  cacctaaac  agactagag  tgacaccaa  ctcacaaag  29400
taaaaccca  ttccttctg  aaccattcc  aatgagaaa  agtcttagc  atccaatct  29460
aacagtcct  cattaagac  cttcctgtt  ggcagtaat  gtacaggcc  ttaattcca  29520
cactcggga  gcagaggca  ggggacgtc  gagttcgaa  aggccaacc  ggtctacag  29580
gtgagttcc  ggacagcca  agtttgtac  gagagaaac  ctgtttggg  ggttggggt  29640
ggcaggtgg  actttcttt  caagtcatt  tgggttgtg  caagttgct  attgtatta  29700
tacatttct  tttccattg  catcaaaag  aacttataa  agaaagcat  tgtttaagc  29760
tatagttcc  gaagggagt  cataatggc  ggggagtca  gacagctaa  gcatgcact  29820
ggggcaaac  ggaagtggg  aaaggctgt  agtctcagc  cgccccagt  acaaacttc  29880
ttccctgag  ccgtacctc  caaaagacc  tctccaagc  tttccacct  ctagggacc  29940
agtgttcac  tttgtgaga  taaggaaac  tcttataga  accacaaca  ttaaggcta  30000
ccaccacag  cattcataa  cttaccact  cacaaattc  atgaataga  aagtaaaaa  30060
tcctcctag  accagacaa  gctcattta  atttggtgg  cacctcctg  gaggcttcc  30120
tattcacag  gctgaaaca  aaatacata  taatttgca  tgtttgttt  ttacaagac  30180
ggatctacg  tgctcatgc  agcttcaat  tttctatct  agcttcatg  gtgatggca  30240
tataagtgg  tgtcactat  tagggctgt  tgctgtgtt  aaaaaatgt  atccatatg  30300
agttatatt  aagtcaatg  cttattctg  ttcacagct  agtggtgtg  attgttcag  30360
ggttcccta  atcaccaca  cttttcctc  ttgtttact  ggctcttag  cacaaaggt  30420
caagcaaat  actatacac  ggctctctc  tgtggacat  ccatagttt  aggagagta  30480
agatccaga  agaaggctg  ctgtttata  tgaaagttg  ttgcttgtt  gtttttttt  30540
tttttttcc  ggagctgag  accgaaccc  ggccttgcg  ttgctaggc  agtgatcta  30600
cactgagct  aatccccaa  ccctgttta  ttgttttta  attttattt  tatgggttg  30660
ccagtggtt  actactaag  tagagtctt  acagtttac  gagcatctg  catgggatt  30720
ctatccttg  gtatgaaac  gcacccaaa  gtctcccta  taccactga  ccgaatcta  30780
aaatacagt  acataccaa  tcggggaga  ctgggtacg  tagcacaac  ctgggtaga  30840
tcccacaac  ctgcaatct  tgactgcag  gtcacagca  gtgtgaagt  agcctgggc  30900
gcattgtaa  ttcctggca  gtctgggct  tatagagac  ccctcacaa  aaacaaatg  30960
acagataaa  aaatatcaa  tactaggta  cagaaaccg  tcattttca  ttcagtagt  31020
ttaatttca  tgtattttc  gaatgttgt  gtaaaaatt  aataaagtg  tggaactgg  31080
tcccacgag  tcccactcc  cgctgggct  ctggtactc  cagacttgg  cggttgcta  31140
ctggtgtta  ttctgtcac  atagggtga  atagaacca  ctttaattt  tctcagcgg  31200
ggctggttc  agtgtggca  atgcctgtt  gcctagcta  cttctagcc  cagcggtct  31260
tctgctccc  ttgctaatc  acctggcca  ccctgacca  ccctgacca  ccctgacca  31320
ccgggaact  tctggttcc  gccactcaa  aaattgtaa  acaacaatc  gatttacct  31380
ttaattctc  atctacaat  catccacag  ataaattca  tgcctatta  taaagatag  31440
aaccaccca  ctagacagt  taatattga  ctagacacc  ggattggaa  cgtcctcca  31500
ctgtctctg  ctccctttc  ccctcctag  cttttccta  cctaccctt  tttctcatc  31560
aatgatagg  tttacctta  cctggaccc  ccttgctac  taatgacaa  atcctacat  31620
agaatcatc  catgacaga  tctagagga  agagtcatg  ggggttttt  tctgtctgt  31680
tctctgtct  ttcatagtt  ttctgctat  tgtttatgt  cttgaacat  tggggga  31737



<210> 3413
<211> 173
<212> PRT
<213> Rattus norvegicus
<308> P10065
<400> 3413

Gly Lys Ile Thr Phe Tyr Glu Asp Arg Gly Phe Gln Gly Arg Cys Tyr 
  1               5                  10                  15
Glu Cys Ser Ser Asp Cys Pro Asn Leu Gln Thr Tyr Phe Ser Arg Cys 
             20                  25                  30
Asn Ser Ile Arg Val Asp Ser Gly Cys Trp Met Leu Tyr Glu Arg Pro 
         35                  40                  45
Asn Tyr Gln Gly Tyr Gln Tyr Phe Leu Arg Arg Gly Asp Tyr Pro Asp 
     50                  55                  60
Tyr Gln Gln Trp Met Gly Phe Ser Asp Ser Ile Arg Ser Cys Arg Ser 
 65                  70                  75                  80
Ile Pro Tyr Thr Ser Ser His Arg Ile Arg Leu Tyr Glu Arg Asp Asp 
                 85                  90                  95
Tyr Arg Gly Leu Val Ser Glu Leu Thr Glu Asp Cys Ser Cys Ile His 
             100                105                110
Asp Arg Phe Arg Leu Asn Glu Ile Tyr Ser Met His Val Leu Glu Gly 
         115                120                125
Ser Trp Val Leu Tyr Glu Met Pro Asn Tyr Arg Gly Arg Gln Tyr Leu 
     130                135                140
Leu Arg Pro Gly Asp Tyr Arg Arg Tyr His Asp Trp Gly Ala Met Asp 
 145                150                155                160
Ala Lys Val Gly Ser Leu Arg Arg Val Met Asp Leu Tyr 
                 165                170



<210> 3414
<211> 465
<212> DNA
<213> Homo sapiens
<308> M17315
<400> 3414

aggtccctt  tgtgttgtt  ttgccaaca  agcagcttc  ctgctatat  taccagttg  60
ccctttgtc  ctatcatac  agatgctaa  caccctctg  caacaacca  ggggaaggt  120
agcctgtgg  ggtgctgtg  catgtctat  gggggtctg  ggtgtgtgg  gatgttcct  180
ccagctgac  gtctactgt  accttattt  tacctcaga  caccttcta  gaggaccga  240
actttcagg  tcgctgcta  aattgcatc  gtgactgcc  caacctgcg  gtctacttc  300
gccgctgca  ctccatccg  gtagacagc  gctgctgga  gctctatga  cgtcccaat  360
accagggcc  ccagtactt  ctgcgccga  gcaagtacc  cgactatca  cactggatg  420
gcctcagcg  ctcggtcca  tcctgccgt  taattcctc  tgtga  465



<210> 3415
<211> 173
<212> PRT
<213> Homo sapiens
<308> P11844
<400> 3415

Gly Lys Ile Thr Phe Tyr Glu Asp Arg Asp Phe Gln Gly Arg Cys Tyr 
  1               5                  10                  15
Asn Cys Ile Ser Asp Cys Pro Asn Leu Arg Val Tyr Phe Ser Arg Cys 
             20                  25                  30
Asn Ser Ile Arg Val Asp Ser Gly Cys Trp Met Leu Tyr Glu Arg Pro 
         35                  40                  45
Asn Tyr Gln Gly His Gln Tyr Phe Leu Arg Arg Gly Lys Tyr Pro Asp 
     50                  55                  60
Tyr Gln His Trp Met Gly Leu Ser Asp Ser Val Gln Ser Cys Arg Ile 
 65                  70                  75                  80
Ile Pro His Thr Ser Ser His Lys Leu Arg Leu Tyr Glu Arg Asp Asp 
                 85                  90                  95
Tyr Arg Gly Leu Met Ser Glu Leu Thr Asp Asp Cys Ala Cys Val Pro 
             100                105                110
Glu Leu Phe Arg Leu Pro Glu Ile Tyr Ser Leu His Val Leu Glu Gly 
         115                120                125
Cys Trp Val Leu Tyr Glu Met Pro Asn Tyr Arg Gly Arg Gln Tyr Leu 
     130                135                140
Leu Arg Leu Gly Asp Tyr Arg Arg Tyr His Asp Trp Gly Gly Ala Asp 
 145                150                155                160
Ala Lys Val Gly Ser Leu Arg Arg Val Thr Asp Leu Tyr 
                 165                170



<210> 3416
<211> 31737
<212> DNA
<213> Rattus norvegicus
<308> M19359
<400> 3416

gaattcttt  tttcacacc  tttccatga  ttataacat  tttattatt  actatattt  60
ttaacagct  ttaaccttc  ttatgactt  tcaatagtt  ttatacaca  atttatgta  120
gaaccactg  tttgatatc  ttgaataag  taaatattt  attaaatat  taaaatatg  180
tttttttgt  gttttcttt  taagacagg  ttttctgtg  agccctggc  gtcctgaaa  240
tcactctgt  gaccaggct  gcctcaaac  tagacatcc  catcaaaag  atgcgacat  300
accacctgg  tgagagtat  cttttatgg  ttttcattt  aggaaattg  ttatcttat  360
tatttggaa  tcttcattt  ccctgtaag  tttaaaccc  tatgtaaca  atctttctt  420
ccaatgttc  ttttatttc  agacaccga  ttttgtcac  aactaagag  aaggcaata  480
cttttcaat  ctcccagct  ttctgggga  catttaagt  ggtgtgttt  gtttgtttg  540
ttggttggt  ggtttggtt  attttattt  gtactagta  cttgtttta  tcagcatgg  600
tatgagcaa  atttcctgg  atagctaat  tccctacac  ttactttct  ttctataaa  660
gaaaacgta  tgggtacct  acagggtta  ttcaagaat  aaatgatta  catatgtac  720
aaggctcag  gaatcaccc  aaccatagc  tgtagaaag  tacctgtcc  ctttcttcc  780
ggagaaccc  cagtatcac  gaaggaagc  agataggag  aggaggaat  taagtttaa  840
ttcaaagta  tagatggaa  atctaaaat  gtatgctac  accacagag  tgaagaatg  900
attattttt  gcagcacta  accaaagaa  tgtgacttt  gtgattatt  ttaaaattt  960
atttggaga  aattgcaag  ttcgagata  gttgcttag  acaaaagac  cagattaac  1020
tctgtgttg  tgtctgtcc  accagctta  tgactttct  tttgtctat  ctccctgct  1080
tctttcgct  gtgtttaca  acattgaca  tcttttctg  gctattaca  cttgtgcat  1140
ccctatcaa  gcaccctgt  tattttact  tgtcctcct  agaaaagcn  agtcatttc  1200
ttaagtaac  aattattaa  ttcagaacc  aaaacattg  tacttttat  caatctatc  1260
ctcacatag  atttttttt  cacttgctc  gataatttc  cctttaagg  tccaacatg  1320
gatcacata  tgccttcag  tgagaaata  aattccttt  cagatattt  agaattgtt  1380
catggaaat  cttttacat  tccatctat  taacccatc  gttggtatc  gatagttga  1440
cttaactcc  atagagagc  agtgtgtgt  tgtgtgtct  tgttataca  atgtgcttg  1500
taccaaaac  atcctgtcc  tctgcaggt  acttagaaa  atggactag  accatggat  1560
tgtaagagc  tctaggagc  gccaggatg  accgcctta  agccacagc  gtcaccggc  1620
gcacacgct  tgtctgcag  tagctcttg  tgtgacctg  attgactct  aagtttcgc  1680
actgagctg  cttctttta  aagcatatc  tccagtttg  caaacggaa  aagtgtgtc  1740
gtctatcct  tgctatttc  ttctatgcc  ggagactgc  ggagcatcc  gagggggtt  1800
actatttct  ggtgtgacc  gacaatctg  ctttgatac  cattttagc  aatgtatat  1860
attaaatat  gcatataat  ctagagaag  aggccgttt  ccaaagttt  aatcccaaa  1920
caaatcaat  tctcattag  atacttcca  aatagagaa  atgtaaact  attccattt  1980
aataaagtt  gaaaagaga  atggatgct  gctctctct  ggtagaaca  gatgaccag  2040
agggaaaga  aatgggctg  tcttttcca  tgccaacaa  gcacatggc  taaccagtg  2100
gcaaaacaa  ttggtcagg  gaatgtcag  acacatcat  ccatctccc  attcctaaa  2160
actgggaca  ccatctcct  gcatgaggg  cttaaggga  tttgttgac  tcttttgaa  2220
atagtgagg  actcccatg  ggggtcatg  ctggggagg  cactgtggg  ctttccaca  2280
ggggcttaa  cacagttgt  cttgaagtt  accaggaca  ttgggaagc  aggatagag  2340
cagagggga  catctgtgg  ctgtagccc  caccatgct  cagccactg  ggactttgc  2400
gactctgct  ctgtgcagc  tcacttcct  ctgtctacc  ttccaccat  tgtacatgc  2460
cgggaaggg  tgaagtgat  cctgaggat  ttcatgtgc  tgcattgct  actctagcc  2520
ggtgtcctc  tgggcatga  tccactacc  aaaatatgc  caggatggg  tgacagcag  2580
taatccaag  ctggaccat  ctccatgcc  gcaataggc  agcacatgg  ggaaaacaa  2640
gaggaaagt  cttatagct  tcaccctgg  tcagggaaa  caacagttt  gtgagggaa  2700
acacagaca  gtctgagca  tggttttaa  aacaaaagg  aatcctgga  gaagagtgg  2760
aacaggaag  atggctgtc  tctcctaac  agtgtgaga  ctattcatt  tagaccaag  2820
agaaatgtt  caccttatc  tcatcacat  tatatatgc  tatcgcatt  tatattata  2880
gtatatgct  tatagatca  atatactta  atttatata  tatagatat  tgcttttaa  2940
cattaactt  aacatcaca  atttaaaat  cactttact  ctttcatct  ctgaattca  3000
aatataaat  tatataata  aaaatttaa  aattttaaa  tcaaaagga  gaaataaaa  3060
gaaggcctc  atataaact  acctaccat  cactgatga  cagggttga  attttagtc  3120
atacacagg  ctaatcttt  tatcttaaa  atgtgcaag  ttcaaaaca  caaaccccc  3180
tactacagg  aaagacatg  aactgtctt  catttagag  aatttgttt  tttttctgc  3240
gctgcctct  ggtgcctga  tgcggctct  gaactcgtg  aattctcat  agctcccac  3300
aacggaggc  ccaccctcc  ctcagcagt  tctataggc  aacactgca  aacgctgcg  3360
acataatgc  tttctagag  gctgcatag  gtgagaagc  cgccctttg  ctccaaggt  3420
ataatggct  tgctgactt  aattccttt  actgagcta  taaggacaa  tcgaaaatg  3480
cagagagaa  gagagcccc  taccccatg  tcccaaatg  aaaagcgag  gaacacaga  3540
atcccctta  acattaccc  ccaggcccc  tttgtgttg  tcttgccaa  acagcagcc  3600
tcctgctgt  tatatatca  ctgccactc  tgtccccat  acactcaac  ctgaccatt  3660
gctgtcaac  acgatggga  aggtgagcc  agggcgaac  ctccaggtc  gttgagtgc  3720
ccctctgtg  gggggatgc  gcttccggt  aaccatgtg  tgttacccc  tctccttta  3780
agatcacct  ctacgagga  cgaggcttc  agggccgct  ctatgagtg  agcagcgac  3840
gccccaacc  gcagaccta  ttcagccgc  gcaactcca  ccgcgtgga  agtggctgc  3900
ggatgctct  tgagcgacc  aactaccag  gctaccagt  cttcctgcg  cgcggggac  3960
accctgact  ccagcagtg  atgggtttc  gcgactcca  tcgctcctg  cgttccatt  4020
cctatgtga  tattgctgc  gccgtgctg  tgtgagaac  ctggtcttc  ttttggcca  4080
tttgttccc  tttctgttc  aatgttctc  gcaaagata  gaatgcttg  caaatgctc  4140
cactaaaac  aaggcccga  tcttacagc  aaatagaac  aacatgtat  cacacccga  4200
cagcagtat  agcaatata  agtttctta  ttaagggca  gagtgtttt  agacataag  4260
aacaacaac  ggaccttta  aactaaact  ggctgaata  gcacatacc  ttcagccat  4320
aaagaagga  atcctgtca  ttgtggtga  atggatgaa  ctggaggtc  ctgtgctaa  4380
aggaaggag  aaggtacgt  atgataaag  ccacaagtt  tcgttcgta  gtgggatct  4440
cagcagcag  ttcatggag  ggtgaagat  gggttgggg  tttacctca  cggtagtgt  4500
cctgtgtag  aagcacgca  ccctgaatt  tgttctgag  gtaaaaatg  gagagagag  4560
gggggggga  ggagaggga  agggagagg  agagggaga  ggagaggga  agggagaga  4620
agagagaga  agagagaga  agaaagaga  agagagaga  actagaggc  agagtggca  4680
agtcaggaa  cagaggttt  gaatgacag  cagaaaaag  aaaattaca  ctagagaga  4740
ctgtgttct  gaaatccgt  gtgaagcat  gcaatgaca  ttcatgtta  ctactagtt  4800
ttaaaatca  gaaaggtaa  gctggaaga  ggctcagtg  ttaggagca  tggctaccc  4860
tcttgagga  ctgggttca  ttccctgcg  ccacaagtg  ctcacaact  aggactcca  4920
tcctaggaa  tcccatgaa  tccaaaagg  caactcatg  agtacactt  caaacacac  4980
ggtaaatac  tacagacat  aaataaaaa  aaatacatc  taaacgcac  ataaaaaaa  5040
gccgaaaga  tggaatcta  gtattttca  cacaaaaat  atgtgagat  agaatatat  5100
tatattgca  aatcaatta  atttggtta  agctagtgt  ttcagattt  attggtgag  5160
tttttttat  ttactatac  ctctcacac  cacctagag  ctagaacaa  gtgtgtcaa  5220
tcgtgtggt  ttggttttt  ttaataagt  attactgac  agtctgtta  gaaacacgt  5280
attagaatt  catgagata  tgtctacat  acctgtctg  aaggaagga  aaagaaaga  5340
agaaagaaa  aaagaaaga  aggaagaaa  agagaaagg  aaaaagaaa  ggaaaagaa  5400
aagaaattt  tgtggactc  aagtaaatc  gaatcattg  acatcatgc  tacaaaagg  5460
agcttcgaa  taagcttag  aggatttgg  tccacgggc  gtaaatgct  tcactccct  5520
cctttcggt  ttcgtttcc  tcacaagag  tcactggtc  ggtcagctt  atgtgagtg  5580
atttcctaa  ctgttacaa  agcagcaca  ggagtaggc  taagggaga  gcacacttg  5640
cagattcgc  cgaaagccg  gttttgtga  tgtgcacag  ggctgtaac  ctgagtgca  5700
acatcgctg  ttctcctct  ctgtcttcc  cacaacaga  cagctctca  aggataagg  5760
tgtacgaga  agatgacta  cggggcctt  tgtctgagc  cacggaaga  tgttcctgc  5820
tccacgacc  cttccgcct  aacgagatc  actccatgc  tgtgctaga  ggcagctgg  5880
tcctctatg  gatgcccaa  taccgaggc  gccagtacc  gctcaggcc  ggagactac  5940
ggcgctacc  cgactgggg  gccatggat  ccaaagtcg  ctctctgag  cgggtcatg  6000
atttgtact  agccccatt  tgcttgtta  aacacacac  tgcaataaa  atacaactt  6060
tgttcctgg  actaagtgg  tctcgctta  cttcaatat  taaatccta  ttagtggtg  6120
cctagtaaa  ttaatgctg  aagaggttt  aaatgtcca  cctctgtcc  cacatcttc  6180
cttgcaaat  ttcattgca  tgagtcatt  tctggttca  ggcctctgg  ttctgtgac  6240
ccatcgtta  cagatcctc  ccagaactc  tcctggtta  cttgttgtt  tcctatgtc  6300
tggagatcc  gcagctttg  atcagcagg  ctgtttctt  cacacatcc  agccatttg  6360
agatgatat  cattttggg  tgggccaac  ctgagccct  gacctgggc  tggtcggca  6420
ctgagttgg  cagcctgcc  gctttccct  atttgtacc  caggacagg  caagctctc  6480
agcactgct  cggctaggc  acccaatcg  tgccattgg  agaggcagg  acctcctct  6540
tctgctctc  tgctctctc  ccctctgga  tgactcaat  ctgcctttg  catcaaggt  6600
agctccact  tgttgccca  tcaaggtac  tggcccgct  tcctgagtg  tacagacag  6660
gaagggaca  ggatagctc  cttattctc  tgatcccag  gccggctct  cccattgcc  6720
cagatggtg  ggggtgagg  ggaactggg  catcacccc  cacctatgc  acctcttgc  6780
cggccagcc  tcctgatct  acatcctca  ggctggttc  acaccccac  accagggtc  6840
acgctgcta  gctgtccag  caaggtaca  ggctcattt  ctgagtgct  aagctggtg  6900
ggggcagcg  tagctctcc  actcttatg  ccccagggc  atctcttcc  gctgcccca  6960
gtggtggga  catgagagg  taggtgttt  tgttttcga  tgaggcacg  tttctctgt  7020
tagccttgg  tgtccagga  gtcactatg  agaccaggt  aggcctcaa  ttcagagac  7080
cctccgcct  cgcctccgc  tccgcctcc  cctccgcct  cgcctccgc  tccgcctcc  7140
cctccgcct  cgcctccgc  tccgcctcc  cctccgcct  cgcctccgc  tccgcctcc  7200
cctctgggt  ctgggatta  aggtgtgag  caccaccac  tgttgataa  attcttaaa  7260
taaattaac  tttaatttt  attaaatcc  accaaagag  aaacaaaca  aagtgttgg  7320
gaggatgta  aaaagttgg  accctttta  attttcgac  ggaatgtaa  atgatgctc  7380
ttcgtagaa  tttgttatc  ctctaaaca  ttgccttag  gctagcaat  ccactatgg  7440
tgacacaag  ctgaaaaca  gggctcaaa  ggaaatcta  acatgaatt  catagtaat  7500
ctttcatgg  agctaaaag  cggacgcag  ccagtgtcc  gatgtcgat  gagttgcca  7560
acaaacaca  tgagaggtg  tatctggcc  tcagaggaa  gaggttctg  tcacgccat  7620
atagtgtac  aagaagact  acacagacc  cagacgaca  agacgacac  gatcacata  7680
gagtgcatc  agttatatg  agtgcccaa  actagaaag  gcattagtg  ctgcttagg  7740
ctgagggga  ggctaacta  ggttgtgat  tctggagta  agctttttg  tgaggcgat  7800
aacatatct  tacacacac  aaaaacact  aactatgaa  atagaacgg  atggccaaa  7860
ctgtctcaa  acactcccc  tctgattca  aaagcttct  aattgaagg  attctttct  7920
actgaaaga  catgtgggg  aaaatgaaa  tataaagct  aaaacactg  gactccaac  7980
agtatcaac  atggcagaa  aacctttgg  ttgctggga  cttggctaa  tcgctatcc  8040
acctgttag  gactaatga  ttacagctg  tgcattcga  tttcctttt  aacaaaaaa  8100
ggtaaaggc  tgggtcagg  ctcatggaa  acatctgtg  taacttgaa  tctcatctc  8160
ttttagtct  gaagaactg  acagtacag  aaactncct  ttcagttca  aaggcttaa  8220
gcattccct  ttttcattt  ccaaaataa  ggtgtggag  aggttcgcg  ccttcaagc  8280
cagacgtga  aaggccctg  aggtttcta  gtgagatgc  tctgtggtt  agtgcctcg  8340
tctggatcc  ataaacttg  tttcggact  tccaccttg  ggctgtgtg  gcttgagcg  8400
ggtctgtgt  ctccctagt  tcgattctg  actttcatg  tctcaggaa  attaaatgg  8460
actccgcct  tccacgcca  cagatcgta  aggctcaat  gataagcac  ctcacgcct  8520
tggtttgcc  ccattacac  cagacctta  ggtcatgtg  gcgctgtct  cagggaagt  8580
acgggagaa  aggagcaga  ggatgagct  tttcccaga  agtttctct  agtcaagtg  8640
atgtgaata  tctatttta  tttgccact  cgcctcaaa  accacaatc  tcctgcctc  8700
gcttctcag  tagctggaa  tctgggcat  tcctacctt  cctacagtg  tctgctgtt  8760
agcttcacc  cttactgct  tatcacatg  ctgtaccca  actaatgaa  cacccttct  8820
gttggtctt  ttaccaaac  agacgatat  aattggtct  atgccgtct  aacacacta  8880
cactccagt  atggccaaa  cacaccaag  ctggcagag  tgagtagac  atgtgggtg  8940
tagggcttg  agattcatt  ctgaagaag  gatctgcac  cctgagaag  tgacatcta  9000
agaggacaa  ccactagca  gtggaaagg  cattagttt  aaagcatta  gtcttgggg  9060
aaatagatg  gtttaatct  cattttctc  cttcactac  gtgcatgcc  ctctataac  9120
taagcaaac  tggagagac  gtgatgccc  aacctcgaa  tatactatc  gttgacata  9180
caaagatgt  aatggatat  acctctgac  agtatcaaa  tgttggcag  ctgtccctc  9240
gatcaaaac  tgagctggg  aattctggt  gctcagctt  gctctgacc  tggacttcc  9300
tctatgctg  tgcacagtg  gattgagcc  caaacctgc  ctctcagtt  ctgactccc  9360
tccagccgt  accaccctg  cccgcattc  tcatttatc  tgctaatca  tttagctgg  9420
gcctcctta  ccttgccgt  tcctcttag  aattctctg  ccagtgtcc  gcttattga  9480
caccaacct  cttgtacat  tgtatggag  cangctaat  cctgctcat  acaaaaccc  9540
cacacatag  tattcctct  acccgcttt  nctatacct  ttgctaaat  gtcttgcca  9600
cattagcag  tagtangac  aatttttct  ccataatga  ttgtttgct  ttaactgat  9660
tagttcntt  tccactcct  attgctttt  gcntgtact  taaaactca  tatgttctt  9720
gattttcat  aattactct  accttataa  tgaggaaac  gaggattga  aggttaaat  9780
agtctccag  gattaaaga  gcattacca  aaattgcta  atatgtgtg  atgtatgta  9840
gcatggttc  cctacacat  ttctccatg  attgtgact  ttcagaagt  cctctgtgt  9900
aaaaaacaa  gttttaaag  aagcaatgt  aaaataaag  attacacag  aggaaagtc  9960
ttccacagt  ttgtttgca  acactggat  ttctaagtc  gtggtcatc  agccctgag  10020
gcatcattt  tgcccaggt  tctgatgct  ccagtttag  aattgtgag  agaagccac  10080
gattacagg  ccagacatt  tcataattc  tcacttatc  gaagaggct  actctcacc  10140
ctgaatcag  attttattt  taggtatct  atttaatcg  caacatgtc  taatacatt  10200
tttgcttca  gaatgcttt  ggactgcca  tntttggtc  agatgttgg  gcaaattct  10260
cagcatcac  tggtgcaag  taaggagta  gcaggatgc  caaatataa  tacctcgat  10320
ctttttcat  tgtaacaaa  tacctgata  aaatacctc  gggaagcaa  gattcattt  10380
gctcacaat  tcggaggat  atcacctga  atggtgagg  aggataatg  ccggagaga  10440
caagccatg  ctgccgatt  catatggta  cccaccggg  gacagaaaa  ttgggctgg  10500
aagagaaga  ataatacaa  acatgcccc  ctgactgac  tattttttt  taattaggt  10560
ccatttgct  aaggttcca  agcctgata  acaaaacac  atatgagga  aaagtcctc  10620
aaacatggg  ctgtggaga  tataacaca  tcaatatgt  catgacccc  caaagagtg  10680
taacaagac  aggatataa  ctcttgctt  ttaagatct  ctatcacca  cccttttta  10740
tagggtggc  taggttacc  cgaaagctg  ttggaccaa  aatgctaac  gtgacaggg  10800
ttatctcga  acactctgt  ccctgggca  tttggagct  cctgaatcc  tcatgccca  10860
aggatatta  attcccttg  tcctgccag  aaaataaac  tttgatcac  tgtgaaatg  10920
agagccaac  gccacttct  agagatcat  gttaccaca  gaaatcctt  cattataac  10980
ggcatccat  tggctatta  aagatggac  ctttgattt  tgtgctcta  gcaccaaac  11040
gactgtaag  gatcctcta  tgccacaga  acggaaccg  gggagcatg  tgctctctt  11100
cccttctaa  cttcatcac  gctggacag  tccagtgga  gaaactgta  tgtctaact  11160
catccactt  ggagctccc  gaagactgc  tcttcattc  ggatcctgt  ctctcaggg  11220
actgtcttc  tcccccaga  cacagaagc  ctggacctg  tctgagatg  ccttctgca  11280
aggagagag  atatcctcg  agctctaaa  gaaacaagc  tccattatt  aagagggga  11340
acggcaaat  cacaaggag  tacagctga  actgagaca  gtgcaaggc  cgggtccta  11400
tggacctgg  ccctttcta  actcctgtt  ctttgtctt  atttatttt  ctttttgga  11460
tttcatacc  catttactc  ttatttctg  gtaagcatt  atactcatg  gtaggtcag  11520
gaagaactt  agggaatta  tcctctcct  ccaccacat  ggacccagg  atctatcag  11580
ttttcaggc  ggataacaa  aagagcctt  cccactgat  tgtcttgct  agccctgat  11640
tattgttct  tcctaagat  attgacctc  ctgtgcatc  gaaccagat  actttgtca  11700
gcatggtga  gcagatctg  agtcccagt  ccaggaggc  gaagcttga  aaacacaaa  11760
aatttgagg  cagccttgg  tacatagta  gtcctgtct  aaagtgtgt  aggtgtgta  11820
gggagaaca  agaggttrg  tgaggctta  taaaaaaca  aggtttata  aaaatatac  11880
gaaacctac  gctttataa  ctaacttta  aaaacaatt  taaagatgt  ttattttaa  11940
tatatgggg  gagtgtggc  tgcgtaaga  tcagaggag  gtataggac  cctcaaagc  12000
ggcgccaac  gtagctgaa  gctctggac  cagacactg  gtcttctat  agaacagta  12060
gtgctttta  ttaccaagc  atttctcca  tccccctgc  ccccgccca  tataaagga  12120
agctctaag  ggctgaata  tgctcctcc  agaagcatt  ggttttaaa  gaaaatccc  12180
gtgctggat  tgggatact  tcctatgag  attaccagg  agatccaaa  tgttagaga  12240
tcttcccac  gcttttggt  gtctgccaa  actagatga  gaaacttca  tgctgcaga  12300
actaaacac  ttggacaca  gacctagag  aaccaagtt  gaactaagc  agaggcctt  12360
tctctgcta  ctagtgttc  gtgtgtcaa  ggttatgca  gggaaaagt  atcaatgtt  12420
ttttccagc  acgggctct  aatgctaca  taccaatat  ccagacaag  tatggctac  12480
gtgggcata  ccaactgct  cctggttgt  tttcaaacc  tcttcatgg  aggaaatat  12540
tattcttgc  attttaact  tggccaaaa  tctatggct  gagacgtcg  cacaggccc  12600
ggtggggaa  gtagtacta  tgttgtttt  ttaaacgga  gtgtagtca  actgccttc  12660
aaatgttta  gattctagc  atacgttag  gtggctttc  ggtgcggtt  gagaatctc  12720
ctctctctc  ctctctctc  ctctctctc  ctctctctc  ctctccaaa  agggtgatg  12780
ttaatacag  gactaatta  tggtgagag  attgaaaat  aatgaatat  aaaatactc  12840
gccttaagt  ggacattgg  aatattccc  gcaaaacct  gcataagaa  aggtagaaa  12900
attgcaatg  ttaagatct  agaggagtg  tatgcaatg  tgttttctg  atttggcat  12960
gccattgga  tcatgggca  atagctacc  tcacaagaa  catacacct  tacataaca  13020
acacacaca  acacacaca  acacacaca  acgcacgca  gcacgcacg  acgcatgca  13080
gcacacaca  acaaatcct  aatgtagga  ggggacccg  cttggaaga  aggagtcag  13140
aggatctta  attgtcgta  atggaatat  aaatgttct  cctttctcc  gcctcatga  13200
ttgaatctt  gccctcagc  gatggccct  cttgaagag  gattggaaa  catgagaga  13260
aaagtctag  ctgggggtc  ggggaggag  ggggtcaag  cagggagtt  ggagtgtct  13320
tgaaggtta  gcttggctt  acccctttc  cctgcttcc  gtctgccct  atgtgaaga  13380
ctcctcctc  ccacacacc  acggatgtt  cgacttacc  caggccaaa  acaatagag  13440
cagggctgt  gaatcccaa  accaaggac  gaaaatgag  ctttctccc  tcctttgtg  13500
cacattgtt  tggtacagt  caccgcctg  ctagtatat  cttcactta  acatcagac  13560
gtcaacgaa  acaggggtg  tttaagtca  attaatgct  actcactga  gtttcgttc  13620
catcctaca  cgagtgaca  tgaatatat  gagttatat  taaaataaa  ttgtggggc  13680
tggagagac  actcagcag  tgagaacac  tcctgaggt  ctcaattcc  agcaaccac  13740
tggtggctc  caaccatct  taatgggat  tgatgcccc  ttctggtgt  tctgaaaac  13800
gtgacatgt  ctcacatac  ttaaaaaat  ataaataaa  attaaaata  aataaagtt  13860
tgactttcc  cctttcaag  gttagaaat  ttagcacat  aaaatgaca  tgtttttca  13920
tgagtcctg  cgggtgaac  tgagtactg  agaagctta  tcaagatat  ggtcctgcc  13980
aggttggag  ccccagtgt  agggaatgt  ggggagagg  ggtggatgg  gaggggaac  14040
gccttatgg  aggggaggg  gatgggata  ggggtttat  tccaggaaa  tcggaaagg  14100
aataacatt  gaaatgaaa  ttaaaaaag  atccaataa  aataaaaag  tatggttaa  14160
agtccggct  gatcattac  ttttctcca  tgaaatagt  actgtttat  aaaaggcta  14220
taggatcac  ttagctggt  ttactgttc  ctttattta  gagggctca  gatggatgg  14280
atgtgtgca  cacactata  caataggga  tgggcttta  atgccttga  gcctggaaa  14340
cagatacca  tgcattacc  tagctggtg  gatcaggac  agtgcttct  agcgtgagc  14400
ctgtggtcc  ctgtcacac  atcactcag  accaaggtg  tccgtccca  agacactga  14460
agctcgaaa  tcagtgcaa  gagcctcca  aacgtccgt  agccaaagg  agctgctga  14520
cgtacctta  cctacattg  ctctctcca  ggtggcaac  tacatcgat  tactgagca  14580
taaaggggc  cgaagtccc  gccccttgt  cagtccatg  ttgctctag  ttccctgag  14640
aagtcacca  cattttatt  tctcacaat  ctaatggca  gcaggagac  ctgtggaaa  14700
gagatggac  agctcagtt  actaatgac  tggcttgat  tatgggttc  agccaaaag  14760
agtgttatt  catgatgag  cctgtggta  gtttgaata  gcttgccca  gagggtgca  14820
tattaggag  tttggcctt  ttggagtaa  tatggcctt  tgggaggan  gtgtgtcac  14880
gtcggaggt  tgagaccct  ctcctgnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  14940
nnnnnnnnn  gcttacagg  tcagaggtt  agtccacta  tatcaaggt  gtgtatggc  15000
gtatccagg  aggcatggt  caggaggaa  tgagggttc  acattttca  ctgaagggc  15060
nnaggagaa  cctggcttc  tcaggcagc  aagaggaag  tctcaacgc  cacactcac  15120
gtgacacac  tcctccaat  agaccacac  tccaaatag  gccatcctg  gccaagcat  15180
tttcaacca  cacagccag  cttctcctg  ctgcctttg  atcaagata  aaaactttt  15240
ctcctccag  cccaggtct  cctggacat  gccatcttc  tgacatgat  ataatggac  15300
gaacctctg  agctgtaag  cagcaccaa  caactgctg  ctcttcaca  cagtggaaa  15360
cttaactaa  ataccacct  actcaggtg  cccccaaaa  tgcagtgaa  gtagtcctc  15420
cagggggaa  ccttaaaga  gtgagtgtt  tgctggaga  atggctcag  ggttagaag  15480
acttgctgt  cttgcagat  acttgggtt  gattttcgg  acccacatg  cagctcatg  15540
ccatctgta  ctgcagtcc  aaaggatcc  aagccctct  ttgatccct  taggcaaaa  15600
gtatgcata  ggtatgcat  cgtatctgc  ggcaaacac  cataaaata  taaaatgaa  15660
aactattta  aatacttgt  tttttttct  gaaaacaac  aaaaaccct  aacccaaaa  15720
ctgacaaag  aaataactt  aaaatattt  atttattta  ttttttctt  aaacaaaac  15780
aaacaaagc  agctggtca  tcacccact  tgtgtgtga  cccagggct  aaaaggagt  15840
actgagcgt  gtgagtcac  tggctagtt  attcggggc  aagaaaggg  gagatctgg  15900
gtaagaagg  ctggggtag  ggtacatgc  tggagctac  gacatagct  cacagtatg  15960
ccctgccac  cactgctgc  tctcacagt  cttccacaa  gagaaaatg  taaaccacc  16020
aagcaagtg  cagaactat  ggaacaaag  actcaaaaa  gtcacatcc  tggcagctc  16080
ggggaaggc  gtgctaact  ctcccgaca  cattaattc  gccattacc  ttatgcatc  16140
tcctgtcca  ctgaaaggc  gaagagtca  gcaccttag  gtgctctct  cttttgagg  16200
agtccacca  cctcttggt  gtaacttga  tacctaggt  ctttccatt  acccttgct  16260
gcatccaca  acatctcac  ggtatttgt  gcctgaagg  tagacagta  acttatatg  16320
taaataaat  gtatatgct  gtgagtaat  accatattt  cccaaagac  acgaaaaga  16380
gcattgttt  gcacttctg  aaatcctta  tttgtgaaa  tgtcagtac  catttgtga  16440
agaatcata  tttcttaaa  tagcaaata  actcagcac  gccctgaaa  ctgtcactt  16500
acgtcgacc  ggggccccc  tggttccca  aactacatg  ataaggcac  ctgtcaagg  16560
accctccac  ctcctccca  cccccactc  acccaccct  cacgctcca  ctcccatgc  16620
caaatcttg  cggtatgta  ccattatcc  aagtctgag  aagttagtg  tgggtgcta  16680
gaaagtttc  gtctggatc  tggacaggn  atcagcaga  gnaagattt  aaagtggag  16740
agcataaga  tagctgttc  tttccccca  tcagggcca  aacaaggtc  tcatgtgca  16800
tgaaactct  ttctaggtg  aagggtgga  aagagacat  acaaactgc  gctaacaat  16860
gtttcagac  gtcccccag  aaacattaa  aatcataga  tcttgaatt  gaactaaac  16920
ttatgcttt  cagaatatt  cctcagatt  aatctccct  actctctct  actcgagat  16980
ccttactgt  taagttttc  ctttaaaaa  aagtttaaa  catacaacc  aaatccgaa  17040
cacgtgcag  tgctaaatc  gatttgctt  gagaagtcc  ttaagccga  taagctata  17100
agtaaacgc  tagaattag  gcttcgcgt  cttttgcaa  acaagagca  agacttttc  17160
cattggtag  aacaacaca  cagctttag  gaattagag  aacccgaac  taccagaaa  17220
aatgagagt  aaccattca  ccaactcca  tgagcagag  gagggagag  gctctccga  17280
cttgcaaat  cccttactc  ctggaatgg  cccttttgt  tgatttcct  tggaggcag  17340
agtcatgac  gctatatat  ccagaggcg  tcccctaga  cctcacagc  cccagggca  17400
ctcttacta  cagcgagat  ggaaaggta  gtcccggaa  cctgacctt  gccctcaag  17460
agcatcctt  ctggcagaa  tcaattatt  gtctggtcc  ctctgccct  acagatcac  17520
ttcttcgag  accgaggct  ccagggccg  tgctatgag  gcagcagcg  ctgccccaa  17580
ctgcagacc  acttcagcc  ctgcaactc  gtccgcgtg  acagtggct  ctggatgct  17640
tatgagcga  ccaactacc  gggccacca  tacttcctg  gacgcgggg  ctaccctga  17700
taccagcag  ggatgggtt  cagcgactc  attcgctcc  gccgcctca  cccccaagt  17760
agtttggct  tgtcctcat  attggtctc  ggaaacaca  attaccttt  aaaaaatca  17820
cttaaacca  gtcgtttca  ttagagcag  gagtgggtc  gacagtatg  gtgttcagt  17880
gtatatcat  tctcaggaa  gtggtgttg  gtttcttag  aaactcaca  ccacctttt  17940
atatttata  gccatcaag  attcaaaca  cagagagta  ttttaaaaa  aggatatcg  18000
agacagtgc  tttatcatt  gcttaacat  taaattccc  gcatatata  agtccttag  18060
tcattccaa  ccacttcta  tcagaaatt  aatgtttct  aatctaaaa  tataatgta  18120
tactatgtc  gtgttttaa  atgcgttgg  tgggtagga  atgctgaag  gatagcagc  18180
agagttcaa  gccagcctg  gctacccac  ttgtatagt  cagaccacc  tgatctcat  18240
taaaaacgt  ttgccttgc  tggccttgc  tttctttct  cttgctttt  ccaccttct  18300
cttttcatt  atttgtagt  gacagtgcc  atgggctcg  ttggaggaa  accccagcg  18360
aaaggccag  tctaaagct  aagtcccag  ctcatgctt  ctggagatg  ccataggta  18420
catcctagg  aggtagagt  tgggagaca  gagacacag  gccacggaa  ctataggaa  18480
gtaacttca  catggagag  tgcccctga  aggaagggt  agcctacag  gaggaagca  18540
ggaaaagcc  atttgaacc  aaactgagg  ttggaaaga  aaagaagga  acacagcac  18600
taatttatc  caggggctc  gccttctga  ttgtagata  gtgaaccaa  acacttcgt  18660
tgcagaaaa  aatcgctga  ggttgatac  ttgtcaaca  gggagataa  tcaaaatgc  18720
accttcctg  taactttta  atttcctcc  ctgcaaagg  ctgtctcag  actgagatg  18780
tatgggttt  attttttaa  tatttttag  ttaagtgtg  tgatcttta  tttaagcaa  18840
ttttaattg  cagggactt  tggatgggt  ggtaggcat  gagagcgct  agggctgtt  18900
ctcaattgg  cattgacac  ctagagtct  caagagaca  cccaagctt  aggaataga  18960
acttccgta  tctgtaaca  gcttgtcct  aacgcaaac  tggacttgg  attttgagg  19020
tggaggtgt  gggacagga  acatctttg  gctcatttg  ttttcttct  ctgtctgcc  19080
ccaccctca  tcccccacc  cagcactcg  gcacttaca  aatgaggat  tacgaaaga  19140
atgacttca  aggacaaat  tcagagatc  cagacgact  tctctctct  caggatcgc  19200
tccacctca  cgagattca  tccctcaat  taatggagg  ctgctgggt  ctctatgag  19260
tgcctagct  cagagggcg  cagtacctg  tgaggccgg  agagtacag  agatatctt  19320
actgggggg  tgcaaacgc  aaagttggc  cttttagaa  agtcatgga  ttttactga  19380
gcattttga  actctactt  tctcctcta  aaactaata  aatatgtag  ttatgattc  19440
ggcaccaca  gagtcctgc  tttctttta  tctcttaag  agagatggg  aggaacttc  19500
tatacgggg  aatagcatt  tgggtattc  aatgactac  tatgtaagg  taaggacct  19560
aagtttaag  tatcaagaa  agtcacagc  ggcctggtg  caggattta  caggtaaag  19620
tgcctgtcc  aagtctgag  gtcccatgt  tgatcccca  gaccctcac  gaaggagag  19680
gtcaattct  ccaagattg  ttttttgat  gaccgcctc  ccccaaccc  cccacaaat  19740
aataaaaat  caatggaaa  aaaattaag  ataagccaa  ccatgacca  tactaaaac  19800
tggtttttc  tacgggtcc  agaaaagag  taactgagt  aaatgtgac  aaaatgacc  19860
gcatttagt  aatgaagtt  cagggctgt  tcttgtaag  ctcataaaa  aagtctgat  19920
agtttaggt  aaaatgcat  agattgccc  atcctttga  aggttaata  gttggctca  19980
atgtcttgc  tggagtggg  actttatac  accaccctt  cctacacag  catgaccgg  20040
aaaaggatt  tgtggccca  cgtcgccct  gcccagagt  tcctgcctc  acactggat  20100
ggcgctcac  ctctcccac  agtgctgat  ttcccatgg  ccaccctga  ccagatgga  20160
aactcgttc  ccaatgacc  ctgacccag  tctcacatg  ggcttcaat  cacacaact  20220
tttttgtta  agaggttcc  gggtatgag  gnaagctta  aataaagca  ggctaatta  20280
agaaattta  cgctagatg  cccctgctt  tgagggtgt  gctcaacag  gagcattta  20340
ttaacatga  taaggccat  aatgcaacc  cgaatatta  aaaaagcaa  aagtacttt  20400
ttcgatggc  tgtggtctg  aggtattag  aggcctgcc  cctttccgt  cttgttccc  20460
tcatcgtgg  acttatctg  gtacacagg  agctacttt  ttttgggac  cctgtcatt  20520
catatcttt  gaaacttca  gttcaatac  taagcactg  atagataca  taagcatat  20580
atcggcaca  aaaatttgt  tactttaga  agttaagga  cttcctatt  ataatcttc  20640
ataattctg  tcaaagaac  gttctgaga  aactggggc  tacaattat  aattttatg  20700
gaatacata  ttagtcagt  aatacctta  aaaatgttg  catataaat  ttaacccta  20760
ttctttaac  tttaactcc  aacatcagt  tatctgtta  aatccactc  gggatatat  20820
caagtctct  ttcaccacc  ctaacacac  aagcatgag  gaggatggc  gaagaggct  20880
gcctgttat  ttcccacta  ttgcttggg  ggcagaaag  ttgcacctg  gccaacgaa  20940
ttattagta  atacctcga  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  21000
nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  agatctgcc  21060
gcctttgct  ccaagtgct  gggtcaaag  tgtggaccg  tatgatcat  atccctgca  21120
ctttctctt  gagtcattg  tcgtgaaaa  tctctgctc  cttctgtgg  atacagaaa  21180
agagatagg  gttctcaca  aacaaaaag  aaaggtcac  aatggagaa  ggcttaggg  21240
aggactata  ccaaactaa  aactactac  actacttct  cacttcctc  cgtcctccc  21300
ctcctcttc  tccttcttt  atttttttt  ttttttttg  gatagggtt  ctctatata  21360
tcttggctg  cccagaact  actctgtag  tcagactgg  ttgactcat  aagtcatgt  21420
tatattcca  ccagaggga  taaaggtgt  tcattccag  cagatcaca  agacctaga  21480
ggnctttgg  cgtgatccc  tgccagagc  gccatgtta  tggataaat  ccttgacag  21540
ttgttttnt  tctgctttt  agtaggctg  gagtggctg  gtncacagt  tggnnatgt  21600
acagttaat  atagtctaa  gtttagcca  nctgactgt  nncacccnn  nnnggctng  21660
acagcacnn  agaggtggg  ttttggttc  ctctggann  nnnnnnnnn  nnnnnnnnn  21720
nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  21780
nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  21840
nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  21900
nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  21960
nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  22020
nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  nnnnnnnnn  22080
nnnnnnnnn  nnnnnnnnn  tactgataa  tatacatgc  cctgcaaac  nnccctnac  22140
catgcttct  taaacaccc  aatgcaact  atggagtca  agtgaacaa  acacacaga  22200
agaagaaag  attggtgtc  gagttttat  gccacaaag  aacattatg  ccatggcac  22260
tcttataaa  gaaaacatt  cattggagc  ggcttacac  ttcagaggt  cggtccatt  22320
ttgtcctga  gggaagcat  gcagcatgc  ggcagacac  gtgctggag  cagagctga  22380
agttctaca  cttgatctg  aggcagcag  aagaaactg  gggccacac  gggcataac  22440
tgagtatat  agacctcaa  gccccccaa  agtgacaca  ctccttcaa  aaggtcatg  22500
ctcctaata  tgccattcc  tatagccac  tgcatctgt  agggttttc  tattcaaac  22560
accacagtt  gggagacta  ttaagaaag  gagtagtaa  agtgtgagg  agataagag  22620
gtaaggcgg  gagtatgat  aaaatagaa  acggggctg  ggatttagc  cagtggtag  22680
gcgcttacc  aggaagcgc  aggccctgg  ttcggtccc  agctccaaa  aaaagaacc  22740
aaaaaaaaa  atagaatat  tacacatgt  aaagagtta  agtgaaatc  atctgaaag  22800
attagcaat  ctagttaaa  taataaaga  aatcttttt  ttttttttg  ttctttttt  22860
cggagctgg  gaccgagaa  cttaataag  tgtgagcaa  accttatct  tgaagtttt  22920
aaagaaaaa  aaaggaatg  gccaggtaa  ttggtacag  ccataattc  agcacttgg  22980
aagatgaga  aggaagatc  cgagttcga  gccagtcca  accacatat  aaatttaaa  23040
ctgaccttg  ctatacaga  agactttgc  tagcgtgtc  tatacagag  taaagctag  23100
cgcaaacca  taaactgag  atgggaccc  attggagaa  ttagagaaa  gattgaagg  23160
gctnnggtg  aaccccata  gcataacaa  gtcaaccaa  cagagctcn  agggactaa  23220
ccattatcc  aagactata  atggacaga  ccagggctc  agctgcata  gtagcagag  23280
atagccttg  tgggcacca  tggaagaag  tcttggtgc  atcaaggtt  gacccccag  23340
gtaggggaa  gtcaggggg  ggggaatag  gagggaggg  tggataggg  ggggaacac  23400
cttatagaa  aagggaggg  tggaatagg  gnnntatgt  caggaaact  ggaaaggga  23460
taacatttg  aatgtaaat  aagaaataa  caataaaaa  aagaaagac  ttgtattaa  23520
gcaaatttt  gaaagtttt  tttgggggg  gggggttga  acagggtat  tccgtgtat  23580
cctagctgt  ctggatttc  ttctgtaga  caggctagt  tcaaactca  agagatttg  23640
ctgcctatg  ctcccaagt  tgggattaa  ggtgtgcac  atcactatc  taaaacaat  23700
tttaaatcg  aactgaaga  ttacaagaa  ctgaaggat  tatttgtta  taattttag  23760
tagcatatc  cagaatgga  ttcattgtg  cattttcac  ccagtttat  attgcacca  23820
tgtacttat  tcatattta  ccctgactt  acctatatc  gtcctaccc  cccctactg  23880
tcccctttt  ttaccacgt  agattattt  agaaataaa  tttccctat  cgagagtag  23940
gtatgatat  tatctttgt  agtctgtaa  ttttattta  tacaaagat  tctggttcc  24000
tccatttct  tgcaagcaa  attcatttc  ttcttcctt  cttaagtag  cattgccac  24060
ttttcttca  tcattcatc  cctaagggg  gttcaaact  cttccacta  tttggctac  24120
gtgaacagt  ctgagagac  cacaggtga  caggttgtt  ctcactgac  ggatcttca  24180
agtttagtc  aagaattat  tagtcctgg  taaaacatg  agatgctaa  attcttgtc  24240
tcatttaat  aggtagaat  ttcttaggg  ccagaaata  gtattttta  aagcactgt  24300
attattaca  acagtagtt  ataaactaa  aagattatt  cttcttctt  ttcttcttc  24360
tcttcttct  cttcttctt  ttcttcttc  tcttcttct  cttctcctt  tccttctcc  24420
tctccttct  cttctcctt  tccttctcc  tctccttct  ctccttctc  ttcttcttt  24480
cctcctcct  cttcttttc  tccttctcc  cctcctcct  tttctcctt  ttcttcttc  24540
ttttgtctt  tttttcttc  ttgagacag  tctctctac  tagctctgg  tgcctggaa  24600
tcaccatgt  gtccaagct  gcctttaat  cacagagat  catcttcct  tgccaagtt  24660
aggggatta  aggcatgca  tgccactcc  agcccccct  acaagattc  taatgttta  24720
tctaaatct  atctttttt  tttttaacc  caaaatagc  ctatagaag  gaaggtttc  24780
ggaaccttt  gagaacact  aacctttgg  caggaagca  gctgacatc  tccttaata  24840
tgtcactct  atgctactg  caatgtcat  aatattacc  gtgttcatc  gcaccaagt  24900
gtgtgccaa  aatggtata  atgtagtct  gttaaggaa  gctaatgtc  attagctaa  24960
catctctag  aactgccta  ctgtaagca  attaagttt  agacttgct  cttccaggg  25020
aaacacata  cctgaggaa  tggggatgt  ttccaatag  tgactttag  agagctgtg  25080
ctcgaatgt  taccttgct  gtgtggttt  agagaggtc  aaaacagtg  aggtctggg  25140
ggagaagcc  atgtatgaa  aaggtcttg  gttcaatcc  taccactgc  atacacagg  25200
agagagaga  aggagtaga  gtgaaaggg  gaggaaagg  gggagagag  gaagaaaga  25260
aacaagaga  aaaaaaagc  cagaaattt  ccagagttg  ctatgcaca  ctgtaatca  25320
agaaccgaa  tggctgagg  aggaggact  cagtatgtt  agggcttgc  taatgagac  25380
ctagggngc  ggggctggg  gtgggggac  aaactgtaa  taaagaagt  acagtgtaa  25440
agtttggtg  tgggcttgg  gggtggtgt  atatgtgtg  gtgtgtgtg  gtgtgtggt  25500
tgtatggat  tgtgtgtga  gtatgtgtg  gcttgtgtg  gtgtgtggt  tgtgtatat  25560
tgtgtatgt  tgtgatgtg  atggatgtg  gggtgtgat  tatgtgtgt  tgttgtgtg  25620
atgtgatat  tgtgagtgt  tgtggtgtg  acgtgatgt  tgtgagtgt  tgtgtgtaa  25680
tgtgtgtgt  tgagtgtgt  tgtatgtgt  tttattagc  aggctctgc  ggcatctat  25740
agacattgt  tttgataaa  aaatagcta  aaagtattt  aaagtgacg  ttagtcatt  25800
gggcccaca  ggacagtac  gtgctcagc  gcctctggg  ggctgtagg  ttgtctttg  25860
tcaaacaaa  tcactttga  taaccttgt  tgaggggac  tattaagac  tgtttatat  25920
taacagctg  atagcaggt  ctaggcaga  gcgctggat  aggtgactc  gacacagga  25980
gtatacgtc  tccctggcc  tggaagcaa  taattctac  ttcgtacat  tttgacggt  26040
ttgggcctc  caaccatag  aattttttc  tttgttctt  actcaagct  gttaccagg  26100
acggatttt  actcacgta  tgtgaaacc  ccaaggtgg  agctagctt  ggtcctaga  26160
tatcagctc  acatagcct  gaaaagcca  gatccaaat  taggtttgt  tcctgtact  26220
aacaagcaa  ccctgtaaa  aaaagcagg  ggaagagga  taagatcgc  tggtctctg  26280
tgcactagt  gctgcagta  tcgaagaat  ccagcattc  caattctgg  gatacttct  26340
cgaatgcgc  gattcctcc  agatttacc  agtataatg  aatcaaaat  tagggacgt  26400
gacttcagg  caaaagttc  ggctgatgt  ctgataaat  taaaaaacg  taagaatcg  26460
aataaagca  ctctgacca  ctagctcat  cagggcagc  ttggaacac  ctagagaac  26520
aggcgaatc  acagtcacc  ccactgaat  cagcccgta  aagccatcc  tgaaattcc  26580
tcagcccgg  gggcccctt  tgtgcagtt  cgctaacac  gcaacaacc  tcctgctat  26640
tagaccggc  ccgctctgc  tggacactg  actcaccac  ggtcagcca  ccatgggga  26700
ggtgagcag  acgcaaact  aacgaaaag  cagactgaa  cgccttgac  caaggagca  26760
aagatctca  tcagaattg  tcttccttt  cagatcacc  tctacgagg  ccgaggctt  26820
cagggccgc  gctatgagt  cagcagcga  tgccccaac  tgcagacct  cttcagccg  26880
tgcaactcc  tccgcgtgg  cagtggctg  tggatgctc  atgagcgcc  caactacca  26940
ggccaccag  acttcctgc  acgcgggga  taccctgac  accagcagt  gatgggttt  27000
agcgactcc  ttcgctcct  ccgcctcat  ccccatgtg  gtcctgttt  atttcattt  27060
ttgctgccg  ggggtcctc  ctgttttac  gatccagag  atagggttt  tttgtctgt  27120
tgtctgtct  tctgtctgt  tgtctgtct  tctgtttgt  tgtttgttt  ttctgagta  27180
ctaagtgtt  agtggtcct  aaatgcctg  ctaagtcta  gagaataca  gcaggaaaa  27240
agaattata  ggaagaatc  actttcaga  ggtccagtt  ttttttgtt  tgttttttt  27300
ttaattttc  ttgctacca  tagattaat  aaaagttgt  ccaacgaat  taatcttat  27360
cagggatat  aaacaaaac  agttgggaa  gagagggta  ttacactca  cagattgat  27420
tttatgtat  taataaagg  attcctggt  agggagtta  ttaaacttt  ttgtggagt  27480
gaaaacatt  aaaagtacg  agatcagaa  ctgtacggg  agaactcaa  tgataattt  27540
ccttagttt  gaagatcgg  tcagttctc  ttataagcg  ttatttaaa  taactttcc  27600
cagaagtgt  tgatttttc  gaactccac  ttagccagg  atagtgata  cctggattc  27660
tagggtcca  gaagctgag  caaaagtat  ttaagtttg  tggtaatct  ggttataaa  27720
taaacagaa  gggacagat  gaaatgata  gaaattctc  aaaaacaaa  atatatata  27780
gtaaaaaat  ctattttat  tataaaaat  atatatttt  atgtataaa  atatatata  27840
ctaaaaaaa  actagttaa  atatgtatt  gtataccct  caacataca  cttagaatg  27900
atataagaa  ttgtgaatt  agatatttt  atttttgat  tgctcaaat  cacttgtaa  27960
atcttataa  tcccacctc  tagatcagt  ggttctcaa  tctcctaat  ccacaaccg  28020
ttaaaaaag  tccttatgt  gtggtgacc  catgccata  aattccttt  gttgctact  28080
cctaactgt  attttgcta  tgtcgcgta  cataatata  atacccgtg  tttccgatg  28140
tcttaagcc  tcactgtaa  caggtcatt  gacctatag  ttgagaacc  ctgttctaa  28200
tgaaaagaa  cctgggcgt  tctaatgcg  gcaggagac  catccatga  tagctctcc  28260
aaatccgtc  ggctcagat  ttactccaa  agccccctg  ctcacccgt  gtttagctt  28320
ggtgagttc  ggaagagac  caactgctc  tttctcatc  ttctttgtg  gacccaagc  28380
gacaggttc  cacaggatg  gtctgtatg  gaaagaaga  cacaaaggc  tcatgatgg  28440
gctgagtga  gactgctcc  gcatccagg  ccgcttcca  ctcagtgag  tgcgctcgc  28500
gcacgtgct  gagggctgc  gggtcctct  tgagatgcc  aactaccga  gccggcagt  28560
tctgctgag  cctcaagag  accggcgct  ccacgactg  ggcgctgta  atgctaagg  28620
aggctcttt  cggagggtg  tagatttat  ctaaaatag  tgaacgcta  cattttctc  28680
ttttggaac  taataaagt  tttagtctg  attgttggc  aaccttgac  tctgttatt  28740
tttcattgt  tgcaaatac  tccacctgt  aactctccc  acagaaggt  gagctgaga  28800
tggagaggt  agggtgttc  agaactttt  aatggtgtt  actttgaac  agtcttaga  28860
ggctgggga  ctatgtatg  gtctcagtg  tagagcttt  attcagtgt  cacaaggtc  28920
tgggctcga  ccctaacac  accagaaag  aaagaaaaa  gttcaggtg  agggagact  28980
tacctggtg  ggtagggag  gtacaccac  tgggggagg  tgtactgtg  tggggaggg  29040
acaccatgt  ggggagggt  taccatgtg  gggaggtta  accatgtgg  ggagggtac  29100
ccatgtggg  gagggtata  tgtgttggg  aaggtatac  atggtagga  ggtatagct  29160
ccggacaat  aaaggccag  tcaagctga  gacacggca  caagacaaa  taccaggga  29220
gaagtagtt  tctgacaac  ttgaagaac  acacagtca  agttgtctt  taatcctgg  29280
agtgattgg  gtccaatgt  gacaaacag  ctatcaaga  tcataagag  actaatttc  29340
tttactata  aacacaata  cacctaaac  agactagag  tgacaccaa  ctcacaaag  29400
taaaaccca  ttccttctg  aaccattcc  aatgagaaa  agtcttagc  atccaatct  29460
aacagtcct  cattaagac  cttcctgtt  ggcagtaat  gtacaggcc  ttaattcca  29520
cactcggga  gcagaggca  ggggacgtc  gagttcgaa  aggccaacc  ggtctacag  29580
gtgagttcc  ggacagcca  agtttgtac  gagagaaac  ctgtttggg  ggttggggt  29640
ggcaggtgg  actttcttt  caagtcatt  tgggttgtg  caagttgct  attgtatta  29700
tacatttct  tttccattg  catcaaaag  aacttataa  agaaagcat  tgtttaagc  29760
tatagttcc  gaagggagt  cataatggc  ggggagtca  gacagctaa  gcatgcact  29820
ggggcaaac  ggaagtggg  aaaggctgt  agtctcagc  cgccccagt  acaaacttc  29880
ttccctgag  ccgtacctc  caaaagacc  tctccaagc  tttccacct  ctagggacc  29940
agtgttcac  tttgtgaga  taaggaaac  tcttataga  accacaaca  ttaaggcta  30000
ccaccacag  cattcataa  cttaccact  cacaaattc  atgaataga  aagtaaaaa  30060
tcctcctag  accagacaa  gctcattta  atttggtgg  cacctcctg  gaggcttcc  30120
tattcacag  gctgaaaca  aaatacata  taatttgca  tgtttgttt  ttacaagac  30180
ggatctacg  tgctcatgc  agcttcaat  tttctatct  agcttcatg  gtgatggca  30240
tataagtgg  tgtcactat  tagggctgt  tgctgtgtt  aaaaaatgt  atccatatg  30300
agttatatt  aagtcaatg  cttattctg  ttcacagct  agtggtgtg  attgttcag  30360
ggttcccta  atcaccaca  cttttcctc  ttgtttact  ggctcttag  cacaaaggt  30420
caagcaaat  actatacac  ggctctctc  tgtggacat  ccatagttt  aggagagta  30480
agatccaga  agaaggctg  ctgtttata  tgaaagttg  ttgcttgtt  gtttttttt  30540
tttttttcc  ggagctgag  accgaaccc  ggccttgcg  ttgctaggc  agtgatcta  30600
cactgagct  aatccccaa  ccctgttta  ttgttttta  attttattt  tatgggttg  30660
ccagtggtt  actactaag  tagagtctt  acagtttac  gagcatctg  catgggatt  30720
ctatccttg  gtatgaaac  gcacccaaa  gtctcccta  taccactga  ccgaatcta  30780
aaatacagt  acataccaa  tcggggaga  ctgggtacg  tagcacaac  ctgggtaga  30840
tcccacaac  ctgcaatct  tgactgcag  gtcacagca  gtgtgaagt  agcctgggc  30900
gcattgtaa  ttcctggca  gtctgggct  tatagagac  ccctcacaa  aaacaaatg  30960
acagataaa  aaatatcaa  tactaggta  cagaaaccg  tcattttca  ttcagtagt  31020
ttaatttca  tgtattttc  gaatgttgt  gtaaaaatt  aataaagtg  tggaactgg  31080
tcccacgag  tcccactcc  cgctgggct  ctggtactc  cagacttgg  cggttgcta  31140
ctggtgtta  ttctgtcac  atagggtga  atagaacca  ctttaattt  tctcagcgg  31200
ggctggttc  agtgtggca  atgcctgtt  gcctagcta  cttctagcc  cagcggtct  31260
tctgctccc  ttgctaatc  acctggcca  ccctgacca  ccctgacca  ccctgacca  31320
ccgggaact  tctggttcc  gccactcaa  aaattgtaa  acaacaatc  gatttacct  31380
ttaattctc  atctacaat  catccacag  ataaattca  tgcctatta  taaagatag  31440
aaccaccca  ctagacagt  taatattga  ctagacacc  ggattggaa  cgtcctcca  31500
ctgtctctg  ctccctttc  ccctcctag  cttttccta  cctaccctt  tttctcatc  31560
aatgatagg  tttacctta  cctggaccc  ccttgctac  taatgacaa  atcctacat  31620
agaatcatc  catgacaga  tctagagga  agagtcatg  ggggttttt  tctgtctgt  31680
tctctgtct  ttcatagtt  ttctgctat  tgtttatgt  cttgaacat  tggggga  31737



<210> 3417
<211> 173
<212> PRT
<213> Rattus norvegicus
<308> AAA40981
<400> 3417

Gly Lys Ile Thr Phe Tyr Glu Asp Arg Gly Phe Gln Gly Arg Cys Tyr 
  1               5                  10                  15
Glu Cys Ser Ser Asp Cys Pro Asn Leu Gln Thr Tyr Phe Ser Arg Cys 
             20                  25                  30
Asn Ser Ile Arg Val Asp Ser Gly Cys Trp Met Leu Tyr Glu Arg Pro 
         35                  40                  45
Asn Tyr Gln Gly Tyr Gln Tyr Phe Leu Arg Arg Gly Asp Tyr Pro Asp 
     50                  55                  60
Tyr Gln Gln Trp Met Gly Phe Ser Asp Ser Ile Arg Ser Cys Arg Ser 
 65                  70                  75                  80
Ile Pro Tyr Thr Ser Ser His Arg Ile Arg Leu Tyr Glu Arg Asp Asp 
                 85                  90                  95
Tyr Arg Gly Leu Val Ser Glu Leu Thr Glu Asp Cys Ser Cys Ile His 
             100                105                110
Asp Arg Phe Arg Leu Asn Glu Ile Tyr Ser Met His Val Leu Glu Gly 
         115                120                125
Ser Trp Val Leu Tyr Glu Met Pro Asn Tyr Arg Gly Arg Gln Tyr Leu 
     130                135                140
Leu Arg Pro Gly Asp Tyr Arg Arg Tyr His Asp Trp Gly Ala Met Asp 
 145                150                155                160
Ala Lys Val Gly Ser Leu Arg Arg Val Met Asp Leu Tyr 
                 165                170



<210> 3418
<211> 607
<212> DNA
<213> Rattus norvegicus
<308> M20156
<400> 3418

catgggtgt  gacattcgc  acaacaagg  ccgaaaggt  cggcgcaag  agcccaaga  60
ccaggatat  tacctgcgg  tgctagtca  gctgtacag  tttctggcc  gacggacca  120
ctccacctt  aaccaggtt  tgctgaaaa  gttatttat  agccgaact  accggccac  180
tctgtccct  tcccgaatg  tccggaaga  gaagcttcc  ggtcgggag  acaaaactg  240
tgtggttgt  gggacgatc  cagatgatg  gcggattct  gaagtgccc  agctgaagg  300
gtgtgcact  agggtgagc  gccgggccc  aagtcggat  ctcaaggct  ggggtaaga  360
cctgacctt  gaccagctg  ccctggagt  tcccaaggg  aggggcact  tgctcttgt  420
tggtcctcg  aagggccga  aggtgtacc  acactttgg  aaggcccca  gaactccac  480
cagccacac  aaaccctat  tccgttcca  gggccggaa  ttcgagcgt  ccagaggcc  540
aagggccag  cgaggctac  aaaactaac  ctggctctt  ctgttaata  aaaagcttt  600
gatgttg  607



<210> 3419
<211> 187
<212> PRT
<213> Rattus norvegicus
<308> P12001
<400> 3419

Gly Val Asp Ile Arg His Asn Lys Asp Arg Lys Val Arg Arg Lys Glu 
  1               5                  10                  15
Pro Lys Ser Gln Asp Ile Tyr Leu Arg Leu Leu Val Lys Leu Tyr Arg 
             20                  25                  30
Phe Leu Ala Arg Arg Thr Asn Ser Thr Phe Asn Gln Val Val Leu Lys 
         35                  40                  45
Arg Leu Phe Met Ser Arg Thr Asn Arg Pro Pro Leu Ser Leu Ser Arg 
     50                  55                  60
Met Ile Arg Lys Met Lys Leu Pro Gly Arg Glu Asn Lys Thr Ala Val 
 65                  70                  75                  80
Val Val Gly Thr Ile Thr Asp Asp Val Arg Ile Leu Glu Val Pro Lys 
                 85                  90                  95
Leu Lys Val Cys Ala Leu Arg Val Ser Ser Arg Ala Arg Ser Arg Ile 
             100                105                110
Leu Lys Ala Gly Gly Lys Ile Leu Thr Phe Asp Gln Leu Ala Leu Glu 
         115                120                125
Ser Pro Lys Gly Arg Gly Thr Val Leu Leu Ser Gly Pro Arg Lys Gly 
     130                135                140
Arg Glu Val Tyr Arg His Phe Gly Lys Ala Pro Gly Thr Pro His Ser 
 145                150                155                160
His Thr Lys Pro Tyr Val Arg Ser Lys Gly Arg Lys Phe Glu Arg Ala 
                 165                170                175
Arg Gly Arg Arg Ala Ser Arg Gly Tyr Lys Asn 
             180                185



<210> 3420
<211> 648
<212> DNA
<213> Homo sapiens
<308> NM_000979
<400> 3420

ctttccgga  ctggccgag  aggaggcgc  atcatggga  tggacatcc  ccataacaa  60
gaccgaaag  ttcggcgca  ggagcccaa  agccaggat  tctacctga  gctgttggt  120
aagttatac  ggtttctgg  cagaagaac  aactccaca  tcaaccagg  tgtgttgaa  180
aggttgttt  tgagtcgca  caaccggcc  cctctgtcc  tttcccgga  gatccggaa  240
atgaagctt  ctggccggg  aaacaagac  gccgtggtt  tggggacca  aactgatga  300
gtgcgggtt  aggaggtac  caaactgaa  gtatgtgca  tgcgcgtga  cagccgggc  360
cgcagccgc  tcctcaggg  agggggcaa  atcctcact  tcgaccagc  ggccctgga  420
tcccctaag  gctgtggca  tgtcctgct  tccggtcct  gcaagggcc  agaggtgta  480
cggcatttc  gcaaggccc  aggaacccc  cacagccac  ccaaaccct  cgtccgctc  540
aagggccgg  agttcgagc  tgccagagg  cgacgggcc  gccgaggct  caaaaacta  600
ccctggatc  tactctctt  ttaaaaaga  ttttgctga  aaaaaaaa  648



<210> 3421
<211> 187
<212> PRT
<213> Homo sapiens
<308> Q07020
<400> 3421

Gly Val Asp Ile Arg His Asn Lys Asp Arg Lys Val Arg Arg Lys Glu 
  1               5                  10                  15
Pro Lys Ser Gln Asp Ile Tyr Leu Arg Leu Leu Val Lys Leu Tyr Arg 
             20                  25                  30
Phe Leu Ala Arg Arg Thr Asn Ser Thr Phe Asn Gln Val Val Leu Lys 
         35                  40                  45
Arg Leu Phe Met Ser Arg Thr Asn Arg Pro Pro Leu Ser Leu Ser Arg 
     50                  55                  60
Met Ile Arg Lys Met Lys Leu Pro Gly Arg Glu Asn Lys Thr Ala Val 
 65                  70                  75                  80
Val Val Gly Thr Ile Thr Asp Asp Val Arg Val Gln Glu Val Pro Lys 
                 85                  90                  95
Leu Lys Val Cys Ala Leu Arg Val Thr Ser Arg Ala Arg Ser Arg Ile 
             100                105                110
Leu Arg Ala Gly Gly Lys Ile Leu Thr Phe Asp Gln Leu Ala Leu Asp 
         115                120                125
Ser Pro Lys Gly Cys Gly Thr Val Leu Leu Ser Gly Pro Arg Lys Gly 
     130                135                140
Arg Glu Val Tyr Arg His Phe Gly Lys Ala Pro Gly Thr Pro His Ser 
 145                150                155                160
His Thr Lys Pro Tyr Val Arg Ser Lys Gly Arg Lys Phe Glu Arg Ala 
                 165                170                175
Arg Gly Arg Arg Ala Ser Arg Gly Tyr Lys Asn 
             180                185



<210> 3422
<211> 8399
<212> DNA
<213> Rattus norvegicus
<308> M22253
<400> 3422

tactgcaga  gtctctggt  catgtgtat  tgtgtgcgt  tgtttgtgt  cgtatgttc  60
gcccctgtc  ggctgcagc  cttgtgaaa  acttggtca  cttttgcaa  aaggaatct  120
tgaatcgtt  caactgaag  tgcggactc  gctcgggag  tgttgttcc  tactgcaga  180
agataattt  cctttttat  aggaatctc  catgaagag  aaagagtaa  taaaatgtg  240
aggatgaca  gatggagca  acagtgctt  taccaccag  acctgacag  ttcaacttc  300
tcaccagag  atctcttgc  gctattgaa  ggcgcattg  agaagaaaa  gctaagaat  360
ccaagccag  caaaaaaga  gatgatgaa  atggcccaa  gccgaacag  gacttggaa  420
ctgggaaga  ccttccatt  atctatgga  acattcctc  agagatggt  tcggagcct  480
tggaggacc  ggaccccta  tatatcaat  agaaaactt  tatagtatt  aataaaggg  540
aggccatct  ccggttcag  gccacttct  ccctgtaca  tttaactcc  ttcaatcct  600
ttaggaaaa  agctattaa  attttggta  actcattat  cagcatgtt  attatgtgc  660
ctattttga  gaactgtgt  tttatgaca  tgagtaacc  tcctgactg  acaaagaat  720
tagagtaca  cttcacagg  atatatacc  ttgaatcac  aataaaaat  attgcaagg  780
gcttctgtt  agaagattt  actttcctt  gtgacccat  gaactggct  gacttcact  840
tcattacat  cgcatatgt  acggagttt  tggacctgg  caatgtctc  gcgttgaga  900
cattcagag  tcttcgagc  ttgaaaaca  tatcagtca  tccaggcct  aagaccatc  960
tgggggccc  gatccagtc  gtgaagaag  tctctgacg  catgatcct  accgtgttc  1020
gtctcagtg  gtttgctct  atcgggttg  agcttttca  gggcaacct  aggaataag  1080
gtgtacagt  gccccccac  aacgcttcc  ttgaggaac  tagcataga  aagaatgta  1140
ctacggatt  caacggcac  cttgtaaat  aaaccgtgt  tgaatttga  tggaaatca  1200
acattcaag  ctcaagata  cattatttc  tggagggtg  tttagatgc  ctactgtgt  1260
gaaatagct  tgatgcagg  caatgtcca  aaggttaca  gtgtgtaaa  gctggcaga  1320
accctaact  tggttacac  agctttgac  ccttcagct  ggcatttct  tccctgttt  1380
gactgatga  tcaggactt  tgggaaaat  tttaccaac  gacattgcg  gctgccggg  1440
aaacataca  gatattttt  gtgctggtc  ttttcttgg  ctcattcta  ctgataaac  1500
tgatcctgg  tgtggtggc  atggcctat  aggaacaga  ccaggccac  ttggaggag  1560
ctgaacaga  ggaggcaga  tttcagcag  tgctggagc  actgaagaa  cagcaggaa  1620
ccgcacagc  ggcggcggc  gcaacagca  cagaacatt  cagggagcc  agtgcagcg  1680
gcaggctct  agatagctc  tcagaagcc  ccaagttga  ttcaaagag  gctaaagaa  1740
ggcggaatc  gaggaaaaa  agaaaacag  aagagcagt  tggagggga  gagaaagat  1800
atgatgaat  ccacaaatc  gagtccgaa  atagcatca  gaggaaggg  ttccgcttc  1860
ccatagaag  gaacagact  acctatgaa  agaggtact  ttccccaca  cagtctctg  1920
tgagcattc  cggctcact  ttttccccg  gacgcaata  cagaacaag  cttttcagc  1980
tcagagggc  agcgaagga  gtggggtct  agaatgatt  tgcggacga  gagcacagc  2040
ccttcgagg  caatgagag  aggagagac  ctctgtttg  tccccgaag  catggagag  2100
gacgcaaca  taacctcag  caaaccagc  gatcctccc  aatgctggc  gggcttcca  2160
caaacggga  gatgcacag  acagtggat  gcaatggtg  ggtttcctt  gtgggcgga  2220
cctcggttc  gacatcgcc  gttggacag  ttctgccag  ggtgataat  gataagcca  2280
ctactgatg  caatggaac  actactgaa  ctgagatga  aaagaggag  tcaagttct  2340
tccatgttt  catggactt  cttgaggat  cttcccaga  gcaaagggc  atgagcatt  2400
ccagcatct  aacaaatac  gtagaagaa  tagaagaat  cagacagaa  tgtccaccc  2460
gttggtata  attttccaa  atattttta  tttgggact  ttctccata  tggctaaaa  2520
ttaaacata  tgtcaacct  gttgtgatg  acccatttg  tgacctggc  attactatc  2580
gtattgtgt  aaataccct  ttcatggcc  tggagcact  ccccatgac  gaacatttc  2640
atcatgtac  tacagtagg  aacttggtt  tcactggga  cttcacagc  gaaatgttc  2700
tgaaaatca  tgccatgga  ccttactat  atttccaag  gggctggaa  atctttgat  2760
gtttcattg  gacactcag  ctggtagaa  ttggccttg  caatgtgga  gggttatca  2820
ttctccgtt  attccgact  ctccgagtc  tcaagttgg  aaagtcctg  cccacactg  2880
acatgctca  taagatcat  ggcaactcg  tgggcgcac  gggcaacct  accctggtg  2940
tggccatca  cgtcttcat  tttgccgtg  tcggcatgc  gctgttcgg  aaaagttac  3000
aagattgtg  ctgcaaaat  gccactgac  gcaaactcc  gcgctggca  atgaacgac  3060
tcttccact  cttcctgat  gtgttccga  tgctgtgtg  ggagtggat  gagaccatg  3120
gggactgca  ggaggtcgc  ggtcaagcc  tgtgcctta  tgtcttcat  atggtcatg  3180
tgattagga  ccttgtggt  ctgaacctc  ttctggcct  gcttctgag  tcatttagt  3240
cagacaacc  tgcagccac  gacgatgac  acgaaatga  caaccttca  attgctgtg  3300
acaggatgc  caaaggagt  gcttatgta  aaagaaaaa  atatgagtt  attcaacag  3360
cctttgtta  gaaacagaa  atcctagat  aaattaagc  acttgatga  ctaaacaac  3420
gaaaagaca  ttgtacatc  aaccacacg  cagagattg  gaaagatct  gactgtctg  3480
aagatgtga  tggaaccac  agtggcata  ggaccggca  cagtgtgga  aagtacatc  3540
ttgatgaga  tgactacat  tcattcata  acaacccca  cctcaccgt  actgtgccc  3600
ttgctgtgg  agagtctga  tttgaaaac  taaacacag  ggactttag  agtgaatca  3660
atctagaag  aagcaaaga  aaactcaac  aaagcagta  ttcctcaga  ggaagcaca  3720
tagacatcg  ggcgcctgc  gaggaacag  ctgtcatgg  accagaaga  acccttgag  3780
ccgaagctt  cttcactga  ggctgtgtg  agagattca  gtgctgtca  atcagtgtg  3840
aagaaggaa  aggaaaaca  tggtggaac  ttcggagaa  gtgcttccg  atagttgag  3900
acaactggt  tgagacctt  attgtgttc  tgattctcc  cagtagtgg  gccctggcc  3960
ttgaggata  atacattga  cagcgaaag  caatcaaga  catgctgga  tatgcagac  4020
aggttttca  ttacatttt  atcctggag  tgctcctca  atgggtagc  tacggctat  4080
aaacgtatt  caccaatgc  tggtgttgg  tggacttct  aattgttga  gtttcattg  4140
tcagtttaa  agcaaatgc  ttgggttac  ctgaacttg  ggccatcaa  tccctaagg  4200
cactaagag  tctgagacc  ctaagagcc  tatcacgat  tgaagggat  agggtggtt  4260
tgaatgccc  gttaggagc  attccatcc  tcatgaatg  gcttctggt  tgccttata  4320
tctggctaa  tttcagcat  atgggcgta  atttgtttg  tggcaaatt  taccactgt  4380
ttaacacca  aactggtga  acatttgag  tcaccgaag  caataatca  tctgattgc  4440
taaaactaa  agaaagaaa  gagactgcc  ggtggaaaa  tgtgaaagt  aactttgat  4500
atgtaggat  tgggtatct  tctttgctt  aagttgcga  gtttaaggg  tggatggat  4560
tcatgtatg  agcagttga  tccagaaat  tggaactgc  gcctaagta  gaggaaagc  4620
tgtacatgt  cctgtactt  gtcatcttc  tcatcttcg  ctcgttctt  actctaaat  4680
tattcatcg  tgtcatcat  gacaacttc  accagcaga  gaagaagtt  ggaggtcaa  4740
acatcttta  gacagaaga  cagaagaaa  actataatg  aatgaagaa  ttaggatca  4800
aaaagccac  aaagcctat  cctcgacct  gaaacaaat  tcaaggaat  gtctttgac  4860
ttgtaacca  acaagtgtt  gacatcagc  tcatgatcc  catctgtct  aacatggtg  4920
ccatgatgg  ggaaacgga  gaccagagc  attatgtga  aagcatttt  tcacgtatc  4980
acctggtgt  cattgtgct  ttcaccggc  agtgcgtgc  gaagctcat  tccctccgc  5040
attattatt  caccattgg  tggaatatt  tcgattttg  ggtggtcat  ctctccatt  5100
taggaatgt  tcttgcgga  ctgatagag  agtatttcg  gtcccctac  ctgttccga  5160
tcatccgcc  ggccaggat  ggacgaatc  tacgcctga  caaaggcgc  aaggggatc  5220
gcactctgc  ctttgctct  atgatgtcc  ttcctgcgc  gttcaacat  ggcctcctg  5280
ttttcctgg  catgttcat  tacgccatc  ttgggatgt  caactttgc  tatgttaag  5340
gggaagttg  aattgatga  atgttcaac  ttgagactt  tggcaacag  atgatctgc  5400
tgttccaaa  caccacctc  gcgggctgg  acggactgc  ggcccccat  ctcaacagc  5460
aaccccctg  ctgtgaccc  aataaagtt  accccggaa  ctcggtgaa  ggggactgt  5520
ggaacccat  cgtggggat  ttctttttt  tcagctaca  catcatatc  ttcctggtg  5580
tggtgaaca  gtacatcgc  gtcatcctg  agaacttca  cgttgccac  gaagaaagt  5640
cagagcccc  gagtgagga  gactttgag  tgttctacg  ggtctggga  aagttcgac  5700
ctgacgcca  tcagttcat  gaatttgaa  aattatctc  gtttgcagc  gctctcgaa  5760
cccctctca  cttaccaca  ccgaacaaa  ttcagctca  tgccatgga  ctgcccatg  5820
tgagtggag  ccgcatcca  tgcctggac  tcttgtttg  ttttacaaa  cgggtcttg  5880
gcgagagtg  agagatgga  gctcttcga  tccagatgg  agaaaggtt  atggcttcc  5940
acccctcca  ggtctccta  cagccaatc  ctacaacgt  aaaacgaaa  caagaggag  6000
tgtcagccg  tatcattca  cgcgcttac  ggcgccacc  tttgaagcg  acagtaaaa  6060
aagcttcat  cacatacaa  aagaacaaa  tcaagggcg  ggctaatct  cttgtaaaa  6120
aagacatga  cattgacag  ataaatgaa  actctatta  agagaaaac  gacctgacg  6180
tgtccactg  agcttgtcc  ccctcctac  accgggtga  aaagccaat  gtggagaaa  6240
acgagcagg  aggaaaaga  gagaaagcc  aagggaaat  aacacaaac  aacaaaaaa  6300
aataaattg  gtgacaaat  gtttacagc  tgtgaagtc  aaggactcc  ttaggaagt  6360
aatgccaaa  tgactgttt  tacacaaat  cactttaag  tcagtgcct  aataagaca  6420
tgaccccct  gtcggcaaa  tctgtgact  ttaggtaaa  gggagatga  cttgacagg  6480
ggttactgt  ctcactacc  gctgacact  ctgaagaca  gagacaaat  gctatgcag  6540
ctgtaggga  cagcgtaaa  gggtgcaga  ctataattt  ggggtttaa  gtgaaacac  6600
ttagtgtag  aactgtatt  accgtttgc  tttcaactg  cacatttgt  aggttttgt  6660
caaactctg  tagtggatt  atctttttt  taaatccat  tgttgtttg  tacatgtga  6720
tatttttgt  aacggggtt  ctgttggga  acagactaa  ggaactctt  tccctgtgt  6780
tcacctggg  gtattgaca  ccatacagc  ctcccatct  cacaacgat  tggttttgc  6840
tgtgagggc  tgctgtacc  tacgatcat  catgagaaa  aagtcacaa  gaaagcaaa  6900
tcggttctt  aacagttct  catcatctg  gtttctgcg  ggggacggg  gggatgtac  6960
gaggtgatc  tgagaccat  ggctttgcc  agctggctt  gtcaactct  gcccttagt  7020
caaggagat  gatcgatca  acaggtcat  gagtcttag  aggtgcaaa  ttcatccaa  7080
tgtctggag  cctgttacg  ttctgttca  tgtctcttc  aagtctcta  attatgact  7140
tgactccct  cccccagcc  tagcagagc  aattgacca  aagaaccct  tataaattc  7200
cgcttaacc  tgcactttg  ttagccatc  tcagctctc  gcgaggttg  cactgtaat  7260
tgttaatga  atgctattt  ttgtgtaaa  agtcatttt  ctctgtggt  cacgtttga  7320
caaacaaat  atgacctaa  cacagtatt  attgcatca  atacgtacc  cgagaaacg  7380
agagtgcaa  ctgtccgct  gtaatatac  gtattctgt  ccattatag  tagtgtgga  7440
gctgtcagt  catgtcgat  ttaccatgc  gcggtatct  gtttctccc  ccactcaga  7500
tctcatact  atgagacac  ataggtcag  ggctaagtc  aggaaaccg  tcagcagat  7560
tcatttctt  aagtcatta  gcaatagtt  gcagcattt  aacaatgtc  gggttgttt  7620
tcaattcta  gtggatgac  ttcaatgta  agccagact  tacatacat  ttcggaaga  7680
aacactact  cttaacctg  taaaacatg  ttagagttt  ataagcaag  ataaataac  7740
gtacaaagt  actttcttt  gtttttcag  atcatgtac  tatgaagag  aaattatct  7800
caggttgat  tcacgatca  ttttcttac  ttccgtcca  agcagtttt  catggaaga  7860
atttgctaa  taagaaatg  aaccatgac  gggtagtgg  agatctctg  ttttttaat  7920
acgggcttt  agtttggat  atttcataa  tttaaggga  aaagtacac  cacaacctc  7980
catccaaat  atgatttgc  attgggaaa  ggtagaaca  ttgatttat  tttattata  8040
tgtctgtgc  aacagatga  cggaatgct  tttttttct  attttttct  tattcccta  8100
tttctgttt  tttttcttt  ctttggaat  acgcatctc  agattgttc  aaatataaa  8160
gtgagcttc  gaatttctt  tcctcaaaa  cagagagga  gacacttac  tagtcaatt  8220
tatcaagat  tttgtgttt  ttacagaag  agaccatag  cacctcttt  tcttaagaa  8280
aaaaatatt  aggcaaacc  tattcatga  ctgcatgtt  gaaaatgct  ctattgccc  8340
aaatgatgc  aatcacaat  aaaaatgtg  aaatctaat  aaaattaat  ttttatttt  8399



<210> 3423
<211> 2009
<212> PRT
<213> Rattus norvegicus
<308> P04774
<400> 3423

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
  1               5                  10                  15
Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
             20                  25                  30
Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
         35                  40                  45
Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
     50                  55                  60
Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
 65                  70                  75                  80
Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Gly 
                 85                  90                  95
Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
             100                105                110
Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
         115                120                125
Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
     130                135                140
Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
 145                150                155                160
Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                 165                170                175
Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
             180                185                190
Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
         195                200                205
Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
     210                215                220
Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
 225                230                235                240
Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                 245                250                255
Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
             260                265                270
Leu Arg Asn Lys Cys Val Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
         275                280                285
Glu His Ser Ile Glu Lys Asn Val Thr Thr Asp Tyr Asn Gly Thr Leu 
     290                295                300
Val Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
 305                310                315                320
Ser Arg Tyr His Tyr Phe Leu Glu Gly Val Leu Asp Ala Leu Leu Cys 
                 325                330                335
Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
             340                345                350
Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
         355                360                365
Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
     370                375                380
Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
 385                390                395                400
Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                 405                410                415
Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
             420                425                430
Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Leu 
         435                440                445
Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Ala Ala 
     450                455                460
Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
 465                470                475                480
Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                 485                490                495
Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
             500                505                510
Glu Glu Lys Asp Asp Asp Glu Phe His Lys Ser Glu Ser Glu Asp Ser 
         515                520                525
Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
     530                535                540
Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
 545                550                555                560
Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                 565                570                575
Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
             580                585                590
Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
         595                600                605
Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
     610                615                620
Thr Ser Arg Ser Ser Arg Met Leu Ala Gly Leu Pro Ala Asn Gly Lys 
 625                630                635                640
Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                 645                650                655
Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
             660                665                670
Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
         675                680                685
Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
     690                695                700
Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
 705                710                715                720
Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                 725                730                735
Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
             740                745                750
Tyr Trp Leu Lys Val Lys His Ile Val Asn Leu Val Val Met Asp Pro 
         755                760                765
Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
     770                775                780
Met Ala Met Glu His Tyr Pro Met Thr Glu His Phe Asn His Val Leu 
 785                790                795                800
Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                 805                810                815
Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
             820                825                830
Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
         835                840                845
Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
     850                855                860
Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
 865                870                875                880
Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                 885                890                895
Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
             900                905                910
Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Thr Asp Cys Lys 
         915                920                925
Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
     930                935                940
Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
 945                950                955                960
Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                 965                970                975
Val Ile Arg Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
             980                985                990
Ser Ser Phe Ser Ala Asp Asn Leu Ala Ala Thr Asp Asp Asp Asn Glu 
         995                1000                1005
Met Asn Asn Leu Gln Ile Ala Val Asp Arg Met His Lys Gly Val Ala 
     1010                1015                1020
Tyr Val Lys Arg Lys Ile Tyr Glu Phe Ile Gln Gln Ser Phe Val Arg 
 1025                1030                1035                1040
Lys Gln Lys Ile Leu Asp Glu Ile Lys Pro Leu Asp Asp Leu Asn Asn 
                 1045                1050                1055
Arg Lys Asp Asn Cys Thr Ser Asn His Thr Thr Glu Ile Gly Lys Asp 
             1060                1065                1070
Leu Asp Cys Leu Lys Asp Val Asn Gly Thr Thr Ser Gly Ile Gly Thr 
         1075                1080                1085
Gly Ser Ser Val Glu Lys Tyr Ile Ile Asp Glu Ser Asp Tyr Met Ser 
     1090                1095                1100
Phe Ile Asn Asn Pro Ser Leu Thr Val Thr Val Pro Ile Ala Val Gly 
 1105                1110                1115                1120
Glu Ser Asp Phe Glu Asn Leu Asn Thr Glu Asp Phe Ser Ser Glu Ser 
                 1125                1130                1135
Asp Leu Glu Glu Ser Lys Glu Lys Leu Asn Glu Ser Ser Ser Ser Ser 
             1140                1145                1150
Glu Gly Ser Thr Val Asp Ile Gly Ala Pro Ala Glu Glu Gln Pro Val 
         1155                1160                1165
Met Glu Pro Glu Glu Thr Leu Glu Pro Glu Ala Cys Phe Thr Glu Gly 
     1170                1175                1180
Cys Val Gln Arg Phe Lys Cys Cys Gln Ile Ser Val Glu Glu Gly Arg 
 1185                1190                1195                1200
Gly Lys Gln Trp Trp Asn Leu Arg Arg Thr Cys Phe Arg Ile Val Glu 
                 1205                1210                1215
His Asn Trp Phe Glu Thr Phe Ile Val Phe Met Ile Leu Leu Ser Ser 
             1220                1225                1230
Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Asp Gln Arg Lys Thr Ile 
         1235                1240                1245
Lys Thr Met Leu Glu Tyr Ala Asp Lys Val Phe Thr Tyr Ile Phe Ile 
     1250                1255                1260
Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Tyr Gln Thr Tyr Phe 
 1265                1270                1275                1280
Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile Val Asp Val Ser Leu 
                 1285                1290                1295
Val Ser Leu Thr Ala Asn Ala Leu Gly Tyr Ser Glu Leu Gly Ala Ile 
             1300                1305                1310
Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg Ala Leu Ser 
         1315                1320                1325
Arg Phe Glu Gly Met Arg Val Val Val Asn Ala Leu Leu Gly Ala Ile 
     1330                1335                1340
Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile Phe Trp Leu Ile 
 1345                1350                1355                1360
Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys Phe Tyr His Cys 
                 1365                1370                1375
Val Asn Thr Thr Thr Gly Asp Thr Phe Glu Ile Thr Glu Val Asn Asn 
             1380                1385                1390
His Ser Asp Cys Leu Lys Leu Ile Glu Arg Asn Glu Thr Ala Arg Trp 
         1395                1400                1405
Lys Asn Val Lys Val Asn Phe Asp Asn Val Gly Phe Gly Tyr Leu Ser 
     1410                1415                1420
Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp Ile Met Tyr Ala 
 1425                1430                1435                1440
Ala Val Asp Ser Arg Asn Val Glu Leu Gln Pro Lys Tyr Glu Glu Ser 
                 1445                1450                1455
Leu Tyr Met Tyr Leu Tyr Phe Val Ile Phe Ile Ile Phe Gly Ser Phe 
             1460                1465                1470
Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp Asn Phe Asn Gln 
         1475                1480                1485
Gln Lys Lys Lys Phe Gly Gly Gln Asp Ile Phe Met Thr Glu Glu Gln 
     1490                1495                1500
Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser Lys Lys Pro Gln 
 1505                1510                1515                1520
Lys Pro Ile Pro Arg Pro Gly Asn Lys Phe Gln Gly Met Val Phe Asp 
                 1525                1530                1535
Phe Val Thr Arg Gln Val Phe Asp Ile Ser Ile Met Ile Leu Ile Cys 
             1540                1545                1550
Leu Asn Met Val Thr Met Met Val Glu Thr Asp Asp Gln Ser Asp Tyr 
         1555                1560                1565
Val Thr Ser Ile Leu Ser Arg Ile Asn Leu Val Phe Ile Val Leu Phe 
     1570                1575                1580
Thr Gly Glu Cys Val Leu Lys Leu Ile Ser Leu Arg His Tyr Tyr Phe 
 1585                1590                1595                1600
Thr Ile Gly Trp Asn Ile Phe Asp Phe Val Val Val Ile Leu Ser Ile 
                 1605                1610                1615
Val Gly Met Phe Leu Ala Glu Leu Ile Glu Lys Tyr Phe Val Ser Pro 
             1620                1625                1630
Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly Arg Ile Leu Arg 
         1635                1640                1645
Leu Ile Lys Gly Ala Lys Gly Ile Arg Thr Leu Leu Phe Ala Leu Met 
     1650                1655                1660
Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu Leu Phe Leu Val 
 1665                1670                1675                1680
Met Phe Ile Tyr Ala Ile Phe Gly Met Ser Asn Phe Ala Tyr Val Lys 
                 1685                1690                1695
Arg Glu Val Gly Ile Asp Asp Met Phe Asn Phe Glu Thr Phe Gly Asn 
             1700                1705                1710
Ser Met Ile Cys Leu Phe Gln Ile Thr Thr Ser Ala Gly Trp Asp Gly 
         1715                1720                1725
Leu Leu Ala Pro Ile Leu Asn Ser Lys Pro Pro Asp Cys Asp Pro Asn 
     1730                1735                1740
Lys Val Asn Pro Gly Ser Ser Val Lys Gly Asp Cys Gly Asn Pro Ser 
 1745                1750                1755                1760
Val Gly Ile Phe Phe Phe Val Ser Tyr Ile Ile Ile Ser Phe Leu Val 
                 1765                1770                1775
Val Val Asn Met Tyr Ile Ala Val Ile Leu Glu Asn Phe Ser Val Ala 
             1780                1785                1790
Thr Glu Glu Ser Ala Glu Pro Leu Ser Glu Asp Asp Phe Glu Met Phe 
         1795                1800                1805
Tyr Glu Val Trp Glu Lys Phe Asp Pro Asp Ala Thr Gln Phe Met Glu 
     1810                1815                1820
Phe Glu Lys Leu Ser Gln Phe Ala Ala Ala Leu Glu Pro Pro Leu Asn 
 1825                1830                1835                1840
Leu Pro Gln Pro Asn Lys Leu Gln Leu Ile Ala Met Asp Leu Pro Met 
                 1845                1850                1855
Val Ser Gly Asp Arg Ile His Cys Leu Asp Ile Leu Phe Ala Phe Thr 
             1860                1865                1870
Lys Arg Val Leu Gly Glu Ser Gly Glu Met Asp Ala Leu Arg Ile Gln 
         1875                1880                1885
Met Glu Glu Arg Phe Met Ala Ser Asn Pro Ser Lys Val Ser Tyr Gln 
     1890                1895                1900
Pro Ile Thr Thr Thr Leu Lys Arg Lys Gln Glu Glu Val Ser Ala Val 
 1905                1910                1915                1920
Ile Ile Gln Arg Ala Tyr Arg Arg His Leu Leu Lys Arg Thr Val Lys 
                 1925                1930                1935
Gln Ala Ser Phe Thr Tyr Asn Lys Asn Lys Leu Lys Gly Gly Ala Asn 
             1940                1945                1950
Leu Leu Val Lys Glu Asp Met Ile Ile Asp Arg Ile Asn Glu Asn Ser 
         1955                1960                1965
Ile Thr Glu Lys Thr Asp Leu Thr Met Ser Thr Ala Ala Cys Pro Pro 
     1970                1975                1980
Ser Tyr Asp Arg Val Thr Lys Pro Ile Val Glu Lys His Glu Gln Glu 
 1985                1990                1995                2000
Gly Lys Asp Glu Lys Ala Lys Gly Lys 
                 2005



<210> 3424
<211> 6046
<212> DNA
<213> Homo sapiens
<308> AY043484
<400> 3424

atggagcaa  cagtgcttg  accaccagg  cctgacagc  tcaacttct  caccagaga  60
tctcttgcg  ctattgaaa  acgcattgc  gaagaaaag  caaagaatc  caaaccaga  120
aaaaaagat  acgacgaaa  tggcccaaa  ccaaatagt  acttggaag  tggaaagaa  180
cttccattt  tttatggag  cattcctcc  gagatggtg  cagagcccc  ggaggacct  240
gacccctac  atatcaata  gaaaacttt  atagtattg  ataaaggga  ggccatctt  300
cggttcagt  ccacctctg  cctgtacat  ttaactccc  tcaatcctc  taggaaaat  360
gctattaag  ttttggtac  ttcattatt  agcatgcta  ttatgtgca  tattttgac  420
aactgtgtg  ttatgacaa  gagtaaccc  cctgattgg  caaagaatg  agartacac  480
ttcacagga  tatatactt  tgaatcact  ataaaaatt  ttgcaaggg  attctgttt  540
gaagatttt  ctttccttc  ggatccatg  aactggctc  atttcactg  cattacatt  600
gcgtacgtc  cagagtttg  ggacctggg  aatgtctcg  cattgagaa  attcagagt  660
ctccgagca  tgaagacga  ttcagtcat  ccaggcctg  aaaccattg  gggagccct  720
atccagtct  tgaagaagc  ctcagatgt  atgatcctg  ctgtgttct  tctgagcgt  780
tttgctcta  ttgggctgc  gctgttcat  ggcaacctg  ggaataaat  tatacaatg  840
cctcccacc  atgcttcct  ggaggaaca  agtatagaa  agaatataa  tgtgaatta  900
aatggtaca  ttataaatg  aactgtctt  gagtttgac  ggaagtcat  tattcaaga  960
tcaagatat  attatttcc  ggagggttt  ttggatgca  tactatgtg  aaatagctc  1020
gatgcaggc  aatgtccag  gggatatat  tgtgtgaaa  ctggtagaa  tcccaatta  1080
ggctacaca  gctttgata  cttcagttg  gcttttttg  ccttgtttc  actaatgac  1140
caggacttc  gggaaaatc  ttatcaact  acattacgt  ctgctggga  aacgtacat  1200
atatttttt  tattggtca  tttcttggg  tcattctac  taataaatt  gatcctggc  1260
gtggtggcc  tggcctacg  ggaacagaa  caggccacc  tggaagaag  agaacagaa  1320
gaggccgaa  ttcagcaga  gattgaaca  cttaaaaag  aacaggagg  agctcagca  1380
gcagcaacg  caactgcct  agaacattc  agagagccc  gtgcagcag  caggctctc  1440
gacagctca  ctgaagcct  taagttgag  tccaagagt  ctaaggaaa  aagaaatcg  1500
aggaagaaa  gaaaacaga  agagcagtc  ggtggggaa  agaaagatg  ggatgaatt  1560
caaaaatct  aatctgagg  cagcatcag  aggaaaggt  ttcgcttct  cattgaagg  1620
aaccgattg  catatgaaa  gaggtactc  tccccacac  agtctttgt  gagcatccg  1680
ggctcccta  tttcaccaa  gcgaaatag  agaacaagc  ttttcagct  tagagggcg  1740
gcaaaggat  tgggatctg  gaacgactt  gcagatgat  agcacagca  ctttgagga  1800
aacgagagc  gtagagatt  cttgtttgt  ccccgacga  acggagaga  acgcaacag  1860
aacctgagt  agaccagta  gtcatcccg  atgctggca  tgtttccag  gaatgggaa  1920
atgcacagc  ctgtggatt  caatggtgt  gtttccttg  ttggtggac  ttcagttcc  1980
acatcgcct  ttggacagc  tctgccaga  ggaacaacc  ctgaaactg  aatgagaaa  2040
agaaggtca  gttctttcc  cgtttccat  gactttcta  aagatcctt  ccaaaggca  2100
cgagcaatg  gtatagcca  cattctaac  aatacagtg  aagaacttg  agaatccag  2160
cagaaatgc  caccctgtt  gtataaatt  tccaacata  tcttaatct  ggactgttc  2220
ccatattgg  taaaagtga  acatgttgt  aacctggtc  tgatggacc  atttgttga  2280
ctggccatc  ccatctgta  tgtcttaaa  actcttttc  tggccatgg  gcactatcc  2340
atgacggac  atttcaata  tgtgcttac  gtaggaaac  tggttttca  tgggatctt  2400
acagcagaa  tgtttctga  aattattgc  atggatcct  actattatt  ccaagaagg  2460
tggaatatc  ttgacggtt  tattgtgac  cttagcctg  tagaacttg  actcgccaa  2520
gtggaagga  tatctgttc  ccgttcatt  cgattgctg  gagttttca  gttggcaaa  2580
tcttggcca  cgttaaata  gctaataaa  atcatcggc  attccgtgg  ggctctggg  2640
aatttaacc  tcgtcttgg  catcatcgt  ttcattttt  ccgtggtcg  catgcagct  2700
tttggtaaa  gctacaaag  ttgtgtctg  aagatcgcc  gtgattgtc  actcccacg  2760
tggcacatg  atgacttct  ccactcctt  ctgattgtg  tccgcgtgc  gtgtgggga  2820
tggatagag  ccatgtggg  ctgtatgga  gttgctggt  aagccatgt  ccttactgt  2880
ttcatgatg  tcatggtga  tggaaacct  gtggtcctg  atctctttc  ggccttgct  2940
ctgagctca  ttagtgcag  caaccttgc  gccactgat  atgataatg  aatgaataa  3000
ctccaaatt  ctgtggata  gatgcacaa  ggagtagct  atgtgaaaa  aaaaatata  3060
gaatttatt  aacagtcct  cattaggaa  caaaagatt  tagatgaaa  taaaccact  3120
gatgatcta  acaacaaga  agacagttg  atgtccaat  atacaacag  aattgggaa  3180
gatcttgac  atcttaaag  tgtaaatgg  actacaagt  gtataggaa  tggcagcag  3240
gttgaaaaa  acattattg  tgaaagtga  tacatgtca  tcataaaca  ccccagtct  3300
actgtgact  taccaattg  tgtaggaga  tctgacttt  aaaatttaa  cacggaaga  3360
tttagtagt  aatcggatc  ggaagaaag  aaagagaaa  tgaatgaaa  cagtagctc  3420
tcagaaggt  gcactgtgg  catcggcgc  cctgtagaa  aacagcccg  agtggaacc  3480
gaagaaact  ttgaaccag  agcttgttt  actgaaggc  gtgtacaaa  attcaagtg  3540
tgtcaaatc  atgtggaag  aggcagagg  aaacaatgg  ggaacctga  aaggacgtg  3600
ttccgaata  ttgaacata  ctggtttga  accttcatt  ttttcatga  tctccttag  3660
agtggtgct  tggcatttg  agatatata  attgatcag  gaaagacga  taagacgat  3720
ttggaatat  ctgacaagg  tttcactta  attttcatt  tggaaatgc  tctaaaatg  3780
gtggcatat  gctatcaaa  atatttcac  aatgcctgg  gttggctgg  cttcttaat  3840
gttgatgtt  cattggtca  tttaacagc  aatgccttg  gttactcag  acttggagc  3900
atcaaatct  tcaggacac  aagagctct  agacctcta  gagccttat  tcgatttga  3960
gggatgagg  tggttgtga  tgccctttt  ggagcaatt  catccatca  gaatgtgct  4020
ctggtttgt  ttatattct  gctaatttt  agcatcatg  gcgtaaatt  gtttgctgg  4080
aaattctac  actgtatta  caccacaac  ggtgacagg  ttgacatcg  agacgtgaa  4140
aatcataca  attgcctaa  actaataga  agaaatgag  ctgctcgat  gaaaaatgt  4200
aaagtaaac  ttgataatg  aggatttgg  tatctctct  tgcttcaag  tgccacatt  4260
aaaggatgg  tggatataa  gtatgcagc  gttgattcc  gaaatgtgg  actccagcc  4320
aagtatgaa  aaagcctgt  catgtatct  tactttgtt  ttttcatca  ctttgggtc  4380
ttcttcacc  tgaacctgt  tattggtgt  atcatagat  atttcaacc  gcagaaaaa  4440
aagtttgga  gtcaagaca  ctttatgac  gaagaacag  agaaatact  taatgcaat  4500
aaaaaatta  gatcgaaaa  accgcaaaa  cctatacct  gaccaggaa  caaatttca  4560
ggaatggtc  ttgacttcg  aaccagaca  gtttttgac  taagcatca  gattctcat  4620
tgtcttaac  tggtcacaa  gatggtgga  acagatgac  agagtgaat  tgtgactac  4680
attttgtca  gcatcaatc  ggtgttcat  gtgctattt  ctggagagt  tgtactgaa  4740
ctcatctct  tacgccatt  ttattttac  attggatgg  atatttttg  ttttgtggt  4800
gtcattctc  ccattgtag  tatgtttct  gccgagctg  tagaaaagt  tttcgtgtc  4860
cctaccctg  tccgagtga  ccgtcttgc  aggattggc  gaatcctac  tctgatcaa  4920
ggagcaaag  ggatccgca  gctgctctt  gctttgatg  tgtcccttc  tgcgttgtt  4980
aacatcggc  tcctactct  cctagtcat  ttcatctac  ccatctttg  gatgtccaa  5040
tttgcctat  ttaagaggg  agttgggat  gatgacatg  tcaactttg  gacctttgg  5100
aacagcatg  tctgcctat  ccaaattac  acctctgct  gctgggatg  attgctagc  5160
cccattctc  acagtaagc  acccgactg  gaccctaat  aagttaacc  tggaagctc  5220
gttaaggga  actgtggga  cccatctgt  ggaattttc  tttttgtca  ttacatcat  5280
atatccttc  tggttgtgg  gaacatgta  atcgcggtc  tcctggaga  cttcagtgt  5340
gctactgaa  aaagtgcag  gcctctgag  gaggatgac  ttgagatgt  ctatgaggt  5400
tgggagaag  ttgatcccg  tgcaactca  ttcatggaa  ttgaaaaat  atctcagtt  5460
gcagctgcg  ttgaaccgc  tctcaatct  ccacaacca  acaaactcc  gctcattgc  5520
atggatttg  ccatggtga  tggtgaccg  atccactgt  ttgatatct  atttgcttt  5580
acaaagcgg  ttctaggag  gagtggaga  atggatgct  tacgaatac  gatggaaga  5640
cgattcatg  cttccaatc  ttccaaggt  tcctatcag  caatcacta  tactttaaa  5700
cgaaaacaa  aggaagtat  tgctgtcat  attcagcgt  cttacagac  ccacctttt  5760
aagcgaact  taaaacaag  ttcctttac  tacaataaa  acaaaatca  aggtggggc  5820
aatcttctt  taaaagaag  catgataat  gacagaata  atgaaaact  tattacaga  5880
aaaactgat  tgaccatgt  cactgcagc  tgtccacct  cctatgacc  ggtgacaaa  5940
ccaattgtg  aaaaacatg  gcaagaagg  aaagatgaa  aagccaaag  gaaatgaat  6000
aaaataaat  aaaataatt  ggtgacaaa  aaaaaaaaa  aaaaaa  6046



<210> 3425
<211> 2009
<212> PRT
<213> Homo sapiens
<308> P35498
<400> 3425

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
  1               5                  10                  15
Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
             20                  25                  30
Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
         35                  40                  45
Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
     50                  55                  60
Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
 65                  70                  75                  80
Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Gly 
                 85                  90                  95
Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
             100                105                110
Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
         115                120                125
Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
     130                135                140
Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
 145                150                155                160
Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                 165                170                175
Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
             180                185                190
Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
         195                200                205
Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
     210                215                220
Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
 225                230                235                240
Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                 245                250                255
Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
             260                265                270
Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
         275                280                285
Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
     290                295                300
Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
 305                310                315                320
Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                 325                330                335
Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
             340                345                350
Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
         355                360                365
Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
     370                375                380
Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
 385                390                395                400
Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                 405                410                415
Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
             420                425                430
Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
         435                440                445
Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
     450                455                460
Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
 465                470                475                480
Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                 485                490                495
Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
             500                505                510
Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
         515                520                525
Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
     530                535                540
Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
 545                550                555                560
Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                 565                570                575
Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
             580                585                590
Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
         595                600                605
Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
     610                615                620
Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
 625                630                635                640
Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                 645                650                655
Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
             660                665                670
Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
         675                680                685
Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
     690                695                700
Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
 705                710                715                720
Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                 725                730                735
Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
             740                745                750
Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
         755                760                765
Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
     770                775                780
Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
 785                790                795                800
Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                 805                810                815
Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
             820                825                830
Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
         835                840                845
Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
     850                855                860
Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
 865                870                875                880
Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                 885                890                895
Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
             900                905                910
Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
         915                920                925
Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
     930                935                940
Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
 945                950                955                960
Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                 965                970                975
Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
             980                985                990
Ser Ser Phe Ser Ala Asp Asn Leu Ala Ala Thr Asp Asp Asp Asn Glu 
         995                1000                1005
Met Asn Asn Leu Gln Ile Ala Val Asp Arg Met His Lys Gly Val Ala 
     1010                1015                1020
Tyr Val Lys Arg Lys Ile Tyr Glu Phe Ile Gln Gln Ser Phe Ile Arg 
 1025                1030                1035                1040
Lys Gln Lys Ile Leu Asp Glu Ile Lys Pro Leu Asp Asp Leu Asn Asn 
                 1045                1050                1055
Lys Lys Asp Ser Cys Met Ser Asn His Thr Ala Glu Ile Gly Lys Asp 
             1060                1065                1070
Leu Asp Tyr Leu Lys Asp Val Asn Gly Thr Thr Ser Gly Ile Gly Thr 
         1075                1080                1085
Gly Ser Ser Val Glu Lys Tyr Ile Ile Asp Glu Ser Asp Tyr Met Ser 
     1090                1095                1100
Phe Ile Asn Asn Pro Ser Leu Thr Val Thr Val Pro Ile Ala Val Gly 
 1105                1110                1115                1120
Glu Ser Asp Phe Glu Asn Leu Asn Thr Glu Asp Phe Ser Ser Glu Ser 
                 1125                1130                1135
Asp Leu Glu Glu Ser Lys Glu Lys Leu Asn Glu Ser Ser Ser Ser Ser 
             1140                1145                1150
Glu Gly Ser Thr Val Asp Ile Gly Ala Pro Val Glu Glu Gln Pro Val 
         1155                1160                1165
Val Glu Pro Glu Glu Thr Leu Glu Pro Glu Ala Cys Phe Thr Glu Gly 
     1170                1175                1180
Cys Val Gln Arg Phe Lys Cys Cys Gln Ile Asn Val Glu Glu Gly Arg 
 1185                1190                1195                1200
Gly Lys Gln Trp Trp Asn Leu Arg Arg Thr Cys Phe Arg Ile Val Glu 
                 1205                1210                1215
His Asn Trp Phe Glu Thr Phe Ile Val Phe Met Ile Leu Leu Ser Ser 
             1220                1225                1230
Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Asp Gln Arg Lys Thr Ile 
         1235                1240                1245
Lys Thr Met Leu Glu Tyr Ala Asp Lys Val Phe Thr Tyr Ile Phe Ile 
     1250                1255                1260
Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Tyr Gln Thr Tyr Phe 
 1265                1270                1275                1280
Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile Val Asp Val Ser Leu 
                 1285                1290                1295
Val Ser Leu Thr Ala Asn Ala Leu Gly Tyr Ser Glu Leu Gly Ala Ile 
             1300                1305                1310
Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg Ala Leu Ser 
         1315                1320                1325
Arg Phe Glu Gly Met Arg Val Val Val Asn Ala Leu Leu Gly Ala Ile 
     1330                1335                1340
Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile Phe Trp Leu Ile 
 1345                1350                1355                1360
Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys Phe Tyr His Cys 
                 1365                1370                1375
Ile Asn Thr Thr Thr Gly Asp Arg Phe Asp Ile Glu Asp Val Asn Asn 
             1380                1385                1390
His Thr Asp Cys Leu Lys Leu Ile Glu Arg Asn Glu Thr Ala Arg Trp 
         1395                1400                1405
Lys Asn Val Lys Val Asn Phe Asp Asn Val Gly Phe Gly Tyr Leu Ser 
     1410                1415                1420
Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp Ile Met Tyr Ala 
 1425                1430                1435                1440
Ala Val Asp Ser Arg Asn Val Glu Leu Gln Pro Lys Tyr Glu Glu Ser 
                 1445                1450                1455
Leu Tyr Met Tyr Leu Tyr Phe Val Ile Phe Ile Ile Phe Gly Ser Phe 
             1460                1465                1470
Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp Asn Phe Asn Gln 
         1475                1480                1485
Gln Lys Lys Lys Phe Gly Gly Gln Asp Ile Phe Met Thr Glu Glu Gln 
     1490                1495                1500
Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser Lys Lys Pro Gln 
 1505                1510                1515                1520
Lys Pro Ile Pro Arg Pro Gly Asn Lys Phe Gln Gly Met Val Phe Asp 
                 1525                1530                1535
Phe Val Thr Arg Gln Val Phe Asp Ile Ser Ile Met Ile Leu Ile Cys 
             1540                1545                1550
Leu Asn Met Val Thr Met Met Val Glu Thr Asp Asp Gln Ser Glu Tyr 
         1555                1560                1565
Val Thr Thr Ile Leu Ser Arg Ile Asn Leu Val Phe Ile Val Leu Phe 
     1570                1575                1580
Thr Gly Glu Cys Val Leu Lys Leu Ile Ser Leu Arg His Tyr Tyr Phe 
 1585                1590                1595                1600
Thr Ile Gly Trp Asn Ile Phe Asp Phe Val Val Val Ile Leu Ser Ile 
                 1605                1610                1615
Val Gly Met Phe Leu Ala Glu Leu Ile Glu Lys Tyr Phe Val Ser Pro 
             1620                1625                1630
Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly Arg Ile Leu Arg 
         1635                1640                1645
Leu Ile Lys Gly Ala Lys Gly Ile Arg Thr Leu Leu Phe Ala Leu Met 
     1650                1655                1660
Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu Leu Phe Leu Val 
 1665                1670                1675                1680
Met Phe Ile Tyr Ala Ile Phe Gly Met Ser Asn Phe Ala Tyr Val Lys 
                 1685                1690                1695
Arg Glu Val Gly Ile Asp Asp Met Phe Asn Phe Glu Thr Phe Gly Asn 
             1700                1705                1710
Ser Met Ile Cys Leu Phe Gln Ile Thr Thr Ser Ala Gly Trp Asp Gly 
         1715                1720                1725
Leu Leu Ala Pro Ile Leu Asn Ser Lys Pro Pro Asp Cys Asp Pro Asn 
     1730                1735                1740
Lys Val Asn Pro Gly Ser Ser Val Lys Gly Asp Cys Gly Asn Pro Ser 
 1745                1750                1755                1760
Val Gly Ile Phe Phe Phe Val Ser Tyr Ile Ile Ile Ser Phe Leu Val 
                 1765                1770                1775
Val Val Asn Met Tyr Ile Ala Val Ile Leu Glu Asn Phe Ser Val Ala 
             1780                1785                1790
Thr Glu Glu Ser Ala Glu Pro Leu Ser Glu Asp Asp Phe Glu Met Phe 
         1795                1800                1805
Tyr Glu Val Trp Glu Lys Phe Asp Pro Asp Ala Thr Gln Phe Met Glu 
     1810                1815                1820
Phe Glu Lys Leu Ser Gln Phe Ala Ala Ala Leu Glu Pro Pro Leu Asn 
 1825                1830                1835                1840
Leu Pro Gln Pro Asn Lys Leu Gln Leu Ile Ala Met Asp Leu Pro Met 
                 1845                1850                1855
Val Ser Gly Asp Arg Ile His Cys Leu Asp Ile Leu Phe Ala Phe Thr 
             1860                1865                1870
Lys Arg Val Leu Gly Glu Ser Gly Glu Met Asp Ala Leu Arg Ile Gln 
         1875                1880                1885
Met Glu Glu Arg Phe Met Ala Ser Asn Pro Ser Lys Val Ser Tyr Gln 
     1890                1895                1900
Pro Ile Thr Thr Thr Leu Lys Arg Lys Gln Glu Glu Val Ser Ala Val 
 1905                1910                1915                1920
Ile Ile Gln Arg Ala Tyr Arg Arg His Leu Leu Lys Arg Thr Val Lys 
                 1925                1930                1935
Gln Ala Ser Phe Thr Tyr Asn Lys Asn Lys Ile Lys Gly Gly Ala Asn 
             1940                1945                1950
Leu Leu Ile Lys Glu Asp Met Ile Ile Asp Arg Ile Asn Glu Asn Ser 
         1955                1960                1965
Ile Thr Glu Lys Thr Asp Leu Thr Met Ser Thr Ala Ala Cys Pro Pro 
     1970                1975                1980
Ser Tyr Asp Arg Val Thr Lys Pro Ile Val Glu Lys His Glu Gln Glu 
 1985                1990                1995                2000
Gly Lys Asp Glu Lys Ala Lys Gly Lys 
                 2005



<210> 3426
<211> 2468
<212> DNA
<213> Rattus norvegicus
<308> M22357
<400> 3426

cagaagcca  accatccaa  gttgactgg  cacttggag  ggaatcagg  gacattccc  60
actcaggga  actgaggtg  gggccctag  tcgcccact  gctggacaa  atgatattc  120
ttaccaccc  gcctctgtt  tggataatg  tttcagctt  tcgaggggg  cactggggt  180
cctggatgc  ctcgtccat  tcagccttc  agggcacgt  tgtctccat  ccctgccgt  240
tcgacttcc  ggatgagct  agaccggct  tggtacatg  cgtctggta  ttcaacagt  300
cctacccca  gaactaccc  ccagtggtc  tcaagtccc  cacacaagt  gtccacgag  360
gcttccagg  ccgtagccg  ctgttggga  acctgggcc  acgaaactg  accctgctt  420
tcagcacgc  gagccctga  ctgggaggg  aatactatt  ccgaggtga  ctgggcggc  480
acaaccagt  caccttctc  gagcacagc  tcctggaca  catcaacac  cccaacatc  540
tggtgcccc  agaagtggt  gcaggaacg  aagtagagg  cagctgcat  gtgccggac  600
actgcccag  gctgcgccc  gagctgagc  ggctgggcc  cgaggggct  ggggagccc  660
ctgttctgg  tcggctgcg  gaggatgaa  gcacctggg  gcaggtgtc  ctgctacac  720
tcgtgccta  tagagaggc  aacggccac  gtctgggct  tcaggctgc  ttccccaac  780
ccaccttgc  gttcgaggg  tacgccagt  tggacgtca  gtacccccc  gtgattgtg  840
agatgaatt  ctctgtgga  gccattgag  gctcccatg  cagcctgct  tgtggggct  900
acagcaacc  gccaccgct  ctgacttgg  tgcgggatg  gatggtgtt  agggaggca  960
ttgctgaga  cctgtacct  gatctggag  aggtgaccc  agcagagga  ggcatctat  1020
cttgcctgg  agagaatgc  tatggccag  acaaccgca  ggtggagct  agcgtcatg  1080
atgcacctt  gaagcccac  gtgaatggg  cggtggtgg  ggtagaggg  gagacagtc  1140
ccatcctgt  ttccacaca  agcaacccg  accctattc  caccatctt  aaggagaag  1200
agatcctgg  cacggtcat  tatgagagt  agctgcagc  ggaactccc  gcagtgacg  1260
ccgaggacg  tggggagta  tggtgtgta  ctgagaacc  gtatggcca  agagccacc  1320
ccttcaacc  gtctgtgga  tttgctccc  taatccttc  ggaatcgca  tgtgcagcg  1380
ccagagaca  cgtgcagtg  ctgtgtgtg  taaaatcca  cccggaacc  tccgtggcc  1440
ttgagctgc  ttcccgcaa  gtgactgtg  acgagacag  gagggagtt  gtgtactca  1500
agcgcagcg  cctcctgct  accagcatc  tcacgctcc  gggtcaggc  caagcccca  1560
cccgcgtca  ttgtacctc  aggaacctc  acggcaccc  gagcctcga  ctgcctttc  1620
agggagcac  ccgactgat  tgggccaaa  tcggccctg  gggtgctgt  gtcgccttt  1680
ccatcctga  tgccattgt  tgctacatc  cccagacaa  aagaaaaaa  aacgtcaca  1740
agagcccca  cttctcagc  ggagacaac  ctcatgtcc  gtacagccc  gaattccga  1800
tctctggag  acctgataa  tatgagtcc  gagaggtct  tacccggga  tgtcactga  1860
agccccagg  gagtgagaa  cgcctgggg  ccgagagga  gctgctggg  cttaggggg  1920
aacccccag  actggacct  agttattcc  actcagacc  ggggaaacg  cccaccaag  1980
acagctaca  cctgacaga  gagctggct  agtacgcag  aatccgagt  aagtgagga  2040
gctgggggc  ggccctgtg  ctcaccccc  atcaggacc  tcgcttggc  cccactggc  2100
gtgggctcc  tttctcttg  gagtggtag  ggtgggggc  ggaaggggc  gggcaggaa  2160
cagtgaggt  ttaggggcc  ggcctcccc  ccttcccgg  tgctcctct  tgccaacat  2220
ctgcaccta  gttacagct  cctctcccc  ccttttaac  tcagctgtt  agaggggtg  2280
tctgtctgt  catgttatt  attgttatc  tggtctcct  tccccttac  cggccccag  2340
acctgtaca  aagggacat  aaataaatg  cctaatgac  agtgccagt  tagacccat  2400
ctttggagg  aaggggcat  ttagtaata  ttttctcgt  gctgtaaca  aatactgga  2460
aaaaacac  2468



<210> 3427
<211> 626
<212> PRT
<213> Rattus norvegicus
<308> P07722
<400> 3427

Met Ile Phe Leu Thr Thr Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
  1               5                  10                  15
Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
             20                  25                  30
Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
         35                  40                  45
Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
     50                  55                  60
Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
 65                  70                  75                  80
Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                 85                  90                  95
Leu Arg Asn Cys Thr Leu Leu Leu Ser Thr Leu Ser Pro Glu Leu Gly 
             100                105                110
Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
         115                120                125
Phe Ser Glu His Ser Val Leu Asp Ile Ile Asn Thr Pro Asn Ile Val 
     130                135                140
Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met 
 145                150                155                160
Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly 
                 165                170                175
His Glu Gly Leu Gly Glu Pro Thr Val Leu Gly Arg Leu Arg Glu Asp 
             180                185                190
Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg 
         195                200                205
Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ala Phe Pro Asn Thr 
     210                215                220
Thr Leu Gln Phe Glu Gly Tyr Ala Ser Leu Asp Val Lys Tyr Pro Pro 
 225                230                235                240
Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His 
                 245                250                255
Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr 
             260                265                270
Trp Met Arg Asp Gly Met Val Leu Arg Glu Ala Val Ala Glu Ser Leu 
         275                280                285
Tyr Leu Asp Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Ile Tyr Ala 
     290                295                300
Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Glu Leu 
 305                310                315                320
Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Val Val 
                 325                330                335
Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn 
             340                345                350
Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ala Thr 
         355                360                365
Val Ile Tyr Glu Ser Gln Leu Gln Leu Glu Leu Pro Ala Val Thr Pro 
     370                375                380
Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln 
 385                390                395                400
Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Ile Ile Leu 
                 405                410                415
Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys 
             420                425                430
Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser 
         435                440                445
Arg Asn Val Thr Val Asn Glu Thr Glu Arg Glu Phe Val Tyr Ser Glu 
     450                455                460
Arg Ser Gly Leu Leu Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala 
 465                470                475                480
Gln Ala Pro Pro Arg Val Ile Cys Thr Ser Arg Asn Leu Tyr Gly Thr 
                 485                490                495
Gln Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala 
             500                505                510
Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala 
         515                520                525
Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu 
     530                535                540
Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro His Val Leu Tyr Ser Pro 
 545                550                555                560
Glu Phe Arg Ile Ser Gly Ala Pro Asp Lys Tyr Glu Ser Glu Lys Arg 
                 565                570                575
Leu Gly Ser Glu Arg Arg Leu Leu Gly Leu Arg Gly Glu Pro Pro Glu 
             580                585                590
Leu Asp Leu Ser Tyr Ser His Ser Asp Leu Gly Lys Arg Pro Thr Lys 
         595                600                605
Asp Ser Tyr Thr Leu Thr Glu Glu Leu Ala Glu Tyr Ala Glu Ile Arg 
     610                615                620
Val Lys 
 625



<210> 3428
<211> 2425
<212> DNA
<213> Homo sapiens
<308> NM_080600
<400> 3428

ctagaccct  gaaggcagg  gactgcgag  tgggctggc  gagcagagg  gcagaagca  60
ctgagtcca  gttgtctgg  ggcttcagg  ggacccaga  gacgtcccc  actcaggga  120
attcagcga  cactcactc  ctgtacaga  tgatattcc  cacggcact  cctctgttc  180
ggattatga  ttcagcctc  cgagggggt  actggggtg  ctggatgcc  tcgtccatc  240
cggccttcg  aggcacgtg  gtctccatc  cctgccgct  tgacttccc  gatgagctg  300
ggcccgctg  ggtgcatgg  gtctggtac  tcaatagcc  ctaccccaa  aactacccc  360
cggtggtct  caagtcgcg  acccaagta  tccacgaga  cttccaggg  cgcagccgc  420
tcctggggg  cctgggcct  cgaaactgc  ccctcctgc  cagcaacgt  agccccgag  480
tgggcggga  gtactactt  cgtggggac  tgggcggct  caaccagta  accttctca  540
agcacagcg  cctggatat  gtcaacacc  ccaacatcg  ggtgccccc  gaggtggtg  600
caggcacgg  ggtggaggt  agctgcatg  tgccggaca  ctgcccaga  ctgcgccct  660
agctgagct  gctgggcca  gaggggctg  gggagcccg  tgtgctggg  cggctgcgg  720
aggacgagg  cacctgggt  caggtgtca  tgctgcact  cgtgcccac  agggaggcc  780
acggccaca  gctgggctg  caggcctcc  tccccaaca  caccctgca  ttcgagggc  840
acgccagca  ggacgtcaa  taccccccg  tgattgtgg  gatgaactc  tcggtggag  900
ccatcgagg  ctcccacgt  agcctgctc  gtggggctg  cagcaaccc  ccgccgctg  960
tgacctgga  gcgggacgg  acagtcctc  gggaggcgg  ggccgagag  ctgctcctg  1020
agctggagg  ggtgacccc  gccgaagac  gcgtctatg  ctgcctggc  gagaatgcc  1080
atggccagg  caaccgcac  gtggggctc  gtgtcatgt  tgcaccctg  aagccaaca  1140
tgaacggga  aatggtggc  gtagagggg  agacggtct  tatcttgtg  tccacacag  1200
gcaacccgg  ccctattct  accatcttc  aggagaagc  gatcctgtc  acggtcatc  1260
acgagagcg  gctgcagct  gagctgccg  ccgtgtcac  cgaggatga  ggagagtac  1320
ggtgtgtgg  tgagaacca  tatggccag  gggccaccg  cttcaacct  tctgtggag  1380
tcgcccctg  gctcctcct  gagtcccac  gcgcggcag  ccgagacac  gtgcagtgc  1440
tgtgcgtgg  gaagtccaa  ccggagccg  ccgtggcct  tgagctgcc  tcgcgcaat  1500
tgaccgtga  cgagagcga  cgggagttc  tgtactcgg  gcgcagcgg  ctcgtgctc  1560
ccagcatcc  cacgctgcg  gggcaggcc  aggccccgc  ccgcgtcat  tgcaccgcg  1620
ggaacctct  tggcgccaa  agcctggag  tgcccttcc  gggagccca  cgactgatg  1680
gggccaaga  cgggcctgt  ggcgccgtg  tcgcctttg  catcctgat  gccatcgtc  1740
gctacatta  ccagacacg  aggaaaaag  acgtgacag  gagccccag  ttctcggca  1800
gggacaacc  tcccgtcct  ttcagcagc  acttccgca  ctctggggc  ccagagaag  1860
acgagtcca  agaggtttc  accctggaa  ctcactgag  gccccagga  agcgagagg  1920
gcctgggat  tgagaggag  ctgctgggc  ttcggggtg  gcccccaga  ctggacctg  1980
gctattctc  ctcggacct  gggaaacgg  ccaccaagg  cagctacac  ctgacggag  2040
agctagctg  gtatgctga  atccgggtc  agtgaagga  ctgggggca  cctgcgtgg  2100
tgacccccc  caggaccct  gctggcccc  actggctgt  ggctccctt  ctcccaaaa  2160
tatcggggg  tggggcagg  ggggagtga  gcaggtgac  gtgaggtcc  gggggcctg  2220
cctccccct  cttcccagc  gcccctccc  gccagcacc  ccacgccct  attacggct  2280
ctctctaac  tcctttacc  tcatctgtc  ggaggggag  tctgtctgt  cgtgttatt  2340
attgctact  cctgcctgg  ctcctgccc  cacacctgg  cctggggcc  gtacaaaag  2400
gacatgaaa  aaatgcccc  aagcc  2425



<210> 3429
<211> 626
<212> PRT
<213> Homo sapiens
<308> P20916
<400> 3429

Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
  1               5                  10                  15
Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
             20                  25                  30
Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
         35                  40                  45
Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
     50                  55                  60
Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
 65                  70                  75                  80
Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                 85                  90                  95
Leu Arg Asn Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly 
             100                105                110
Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
         115                120                125
Phe Ser Glu His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val 
     130                135                140
Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met 
 145                150                155                160
Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly 
                 165                170                175
His Glu Gly Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp 
             180                185                190
Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg 
         195                200                205
Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr 
     210                215                220
Thr Leu Gln Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro 
 225                230                235                240
Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His 
                 245                250                255
Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr 
             260                265                270
Trp Met Arg Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu 
         275                280                285
Leu Leu Glu Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala 
     290                295                300
Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu 
 305                310                315                320
Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val 
                 325                330                335
Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn 
             340                345                350
Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr 
         355                360                365
Val Ile Tyr Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro 
     370                375                380
Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln 
 385                390                395                400
Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu 
                 405                410                415
Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys 
             420                425                430
Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser 
         435                440                445
Arg Asn Val Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu 
     450                455                460
Arg Ser Gly Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala 
 465                470                475                480
Gln Ala Pro Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala 
                 485                490                495
Lys Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala 
             500                505                510
Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala 
         515                520                525
Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu 
     530                535                540
Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro Pro Val Leu Phe Ser Ser 
 545                550                555                560
Asp Phe Arg Ile Ser Gly Ala Pro Glu Lys Tyr Glu Ser Glu Arg Arg 
                 565                570                575
Leu Gly Ser Glu Arg Arg Leu Leu Gly Leu Arg Gly Glu Pro Pro Glu 
             580                585                590
Leu Asp Leu Ser Tyr Ser His Ser Asp Leu Gly Lys Arg Pro Thr Lys 
         595                600                605
Asp Ser Tyr Thr Leu Thr Glu Glu Leu Ala Glu Tyr Ala Glu Ile Arg 
     610                615                620
Val Lys 
 625



<210> 3430
<211> 2468
<212> DNA
<213> Rattus norvegicus
<308> M22357
<400> 3430

cagaagcca  accatccaa  gttgactgg  cacttggag  ggaatcagg  gacattccc  60
actcaggga  actgaggtg  gggccctag  tcgcccact  gctggacaa  atgatattc  120
ttaccaccc  gcctctgtt  tggataatg  tttcagctt  tcgaggggg  cactggggt  180
cctggatgc  ctcgtccat  tcagccttc  agggcacgt  tgtctccat  ccctgccgt  240
tcgacttcc  ggatgagct  agaccggct  tggtacatg  cgtctggta  ttcaacagt  300
cctacccca  gaactaccc  ccagtggtc  tcaagtccc  cacacaagt  gtccacgag  360
gcttccagg  ccgtagccg  ctgttggga  acctgggcc  acgaaactg  accctgctt  420
tcagcacgc  gagccctga  ctgggaggg  aatactatt  ccgaggtga  ctgggcggc  480
acaaccagt  caccttctc  gagcacagc  tcctggaca  catcaacac  cccaacatc  540
tggtgcccc  agaagtggt  gcaggaacg  aagtagagg  cagctgcat  gtgccggac  600
actgcccag  gctgcgccc  gagctgagc  ggctgggcc  cgaggggct  ggggagccc  660
ctgttctgg  tcggctgcg  gaggatgaa  gcacctggg  gcaggtgtc  ctgctacac  720
tcgtgccta  tagagaggc  aacggccac  gtctgggct  tcaggctgc  ttccccaac  780
ccaccttgc  gttcgaggg  tacgccagt  tggacgtca  gtacccccc  gtgattgtg  840
agatgaatt  ctctgtgga  gccattgag  gctcccatg  cagcctgct  tgtggggct  900
acagcaacc  gccaccgct  ctgacttgg  tgcgggatg  gatggtgtt  agggaggca  960
ttgctgaga  cctgtacct  gatctggag  aggtgaccc  agcagagga  ggcatctat  1020
cttgcctgg  agagaatgc  tatggccag  acaaccgca  ggtggagct  agcgtcatg  1080
atgcacctt  gaagcccac  gtgaatggg  cggtggtgg  ggtagaggg  gagacagtc  1140
ccatcctgt  ttccacaca  agcaacccg  accctattc  caccatctt  aaggagaag  1200
agatcctgg  cacggtcat  tatgagagt  agctgcagc  ggaactccc  gcagtgacg  1260
ccgaggacg  tggggagta  tggtgtgta  ctgagaacc  gtatggcca  agagccacc  1320
ccttcaacc  gtctgtgga  tttgctccc  taatccttc  ggaatcgca  tgtgcagcg  1380
ccagagaca  cgtgcagtg  ctgtgtgtg  taaaatcca  cccggaacc  tccgtggcc  1440
ttgagctgc  ttcccgcaa  gtgactgtg  acgagacag  gagggagtt  gtgtactca  1500
agcgcagcg  cctcctgct  accagcatc  tcacgctcc  gggtcaggc  caagcccca  1560
cccgcgtca  ttgtacctc  aggaacctc  acggcaccc  gagcctcga  ctgcctttc  1620
agggagcac  ccgactgat  tgggccaaa  tcggccctg  gggtgctgt  gtcgccttt  1680
ccatcctga  tgccattgt  tgctacatc  cccagacaa  aagaaaaaa  aacgtcaca  1740
agagcccca  cttctcagc  ggagacaac  ctcatgtcc  gtacagccc  gaattccga  1800
tctctggag  acctgataa  tatgagtcc  gagaggtct  tacccggga  tgtcactga  1860
agccccagg  gagtgagaa  cgcctgggg  ccgagagga  gctgctggg  cttaggggg  1920
aacccccag  actggacct  agttattcc  actcagacc  ggggaaacg  cccaccaag  1980
acagctaca  cctgacaga  gagctggct  agtacgcag  aatccgagt  aagtgagga  2040
gctgggggc  ggccctgtg  ctcaccccc  atcaggacc  tcgcttggc  cccactggc  2100
gtgggctcc  tttctcttg  gagtggtag  ggtgggggc  ggaaggggc  gggcaggaa  2160
cagtgaggt  ttaggggcc  ggcctcccc  ccttcccgg  tgctcctct  tgccaacat  2220
ctgcaccta  gttacagct  cctctcccc  ccttttaac  tcagctgtt  agaggggtg  2280
tctgtctgt  catgttatt  attgttatc  tggtctcct  tccccttac  cggccccag  2340
acctgtaca  aagggacat  aaataaatg  cctaatgac  agtgccagt  tagacccat  2400
ctttggagg  aaggggcat  ttagtaata  ttttctcgt  gctgtaaca  aatactgga  2460
aaaaacac  2468



<210> 3431
<211> 626
<212> PRT
<213> Rattus norvegicus
<308> P07722
<400> 3431

Met Ile Phe Leu Thr Thr Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
  1               5                  10                  15
Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
             20                  25                  30
Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
         35                  40                  45
Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
     50                  55                  60
Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
 65                  70                  75                  80
Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                 85                  90                  95
Leu Arg Asn Cys Thr Leu Leu Leu Ser Thr Leu Ser Pro Glu Leu Gly 
             100                105                110
Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
         115                120                125
Phe Ser Glu His Ser Val Leu Asp Ile Ile Asn Thr Pro Asn Ile Val 
     130                135                140
Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met 
 145                150                155                160
Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly 
                 165                170                175
His Glu Gly Leu Gly Glu Pro Thr Val Leu Gly Arg Leu Arg Glu Asp 
             180                185                190
Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg 
         195                200                205
Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ala Phe Pro Asn Thr 
     210                215                220
Thr Leu Gln Phe Glu Gly Tyr Ala Ser Leu Asp Val Lys Tyr Pro Pro 
 225                230                235                240
Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His 
                 245                250                255
Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr 
             260                265                270
Trp Met Arg Asp Gly Met Val Leu Arg Glu Ala Val Ala Glu Ser Leu 
         275                280                285
Tyr Leu Asp Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Ile Tyr Ala 
     290                295                300
Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Glu Leu 
 305                310                315                320
Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Val Val 
                 325                330                335
Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn 
             340                345                350
Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ala Thr 
         355                360                365
Val Ile Tyr Glu Ser Gln Leu Gln Leu Glu Leu Pro Ala Val Thr Pro 
     370                375                380
Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln 
 385                390                395                400
Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Ile Ile Leu 
                 405                410                415
Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys 
             420                425                430
Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser 
         435                440                445
Arg Asn Val Thr Val Asn Glu Thr Glu Arg Glu Phe Val Tyr Ser Glu 
     450                455                460
Arg Ser Gly Leu Leu Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala 
 465                470                475                480
Gln Ala Pro Pro Arg Val Ile Cys Thr Ser Arg Asn Leu Tyr Gly Thr 
                 485                490                495
Gln Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala 
             500                505                510
Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala 
         515                520                525
Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu 
     530                535                540
Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro His Val Leu Tyr Ser Pro 
 545                550                555                560
Glu Phe Arg Ile Ser Gly Ala Pro Asp Lys Tyr Glu Ser Glu Lys Arg 
                 565                570                575
Leu Gly Ser Glu Arg Arg Leu Leu Gly Leu Arg Gly Glu Pro Pro Glu 
             580                585                590
Leu Asp Leu Ser Tyr Ser His Ser Asp Leu Gly Lys Arg Pro Thr Lys 
         595                600                605
Asp Ser Tyr Thr Leu Thr Glu Glu Leu Ala Glu Tyr Ala Glu Ile Arg 
     610                615                620
Val Lys 
 625



<210> 3432
<211> 2425
<212> DNA
<213> Homo sapiens
<308> NM_080600
<400> 3432

ctagaccct  gaaggcagg  gactgcgag  tgggctggc  gagcagagg  gcagaagca  60
ctgagtcca  gttgtctgg  ggcttcagg  ggacccaga  gacgtcccc  actcaggga  120
attcagcga  cactcactc  ctgtacaga  tgatattcc  cacggcact  cctctgttc  180
ggattatga  ttcagcctc  cgagggggt  actggggtg  ctggatgcc  tcgtccatc  240
cggccttcg  aggcacgtg  gtctccatc  cctgccgct  tgacttccc  gatgagctg  300
ggcccgctg  ggtgcatgg  gtctggtac  tcaatagcc  ctaccccaa  aactacccc  360
cggtggtct  caagtcgcg  acccaagta  tccacgaga  cttccaggg  cgcagccgc  420
tcctggggg  cctgggcct  cgaaactgc  ccctcctgc  cagcaacgt  agccccgag  480
tgggcggga  gtactactt  cgtggggac  tgggcggct  caaccagta  accttctca  540
agcacagcg  cctggatat  gtcaacacc  ccaacatcg  ggtgccccc  gaggtggtg  600
caggcacgg  ggtggaggt  agctgcatg  tgccggaca  ctgcccaga  ctgcgccct  660
agctgagct  gctgggcca  gaggggctg  gggagcccg  tgtgctggg  cggctgcgg  720
aggacgagg  cacctgggt  caggtgtca  tgctgcact  cgtgcccac  agggaggcc  780
acggccaca  gctgggctg  caggcctcc  tccccaaca  caccctgca  ttcgagggc  840
acgccagca  ggacgtcaa  taccccccg  tgattgtgg  gatgaactc  tcggtggag  900
ccatcgagg  ctcccacgt  agcctgctc  gtggggctg  cagcaaccc  ccgccgctg  960
tgacctgga  gcgggacgg  acagtcctc  gggaggcgg  ggccgagag  ctgctcctg  1020
agctggagg  ggtgacccc  gccgaagac  gcgtctatg  ctgcctggc  gagaatgcc  1080
atggccagg  caaccgcac  gtggggctc  gtgtcatgt  tgcaccctg  aagccaaca  1140
tgaacggga  aatggtggc  gtagagggg  agacggtct  tatcttgtg  tccacacag  1200
gcaacccgg  ccctattct  accatcttc  aggagaagc  gatcctgtc  acggtcatc  1260
acgagagcg  gctgcagct  gagctgccg  ccgtgtcac  cgaggatga  ggagagtac  1320
ggtgtgtgg  tgagaacca  tatggccag  gggccaccg  cttcaacct  tctgtggag  1380
tcgcccctg  gctcctcct  gagtcccac  gcgcggcag  ccgagacac  gtgcagtgc  1440
tgtgcgtgg  gaagtccaa  ccggagccg  ccgtggcct  tgagctgcc  tcgcgcaat  1500
tgaccgtga  cgagagcga  cgggagttc  tgtactcgg  gcgcagcgg  ctcgtgctc  1560
ccagcatcc  cacgctgcg  gggcaggcc  aggccccgc  ccgcgtcat  tgcaccgcg  1620
ggaacctct  tggcgccaa  agcctggag  tgcccttcc  gggagccca  cgactgatg  1680
gggccaaga  cgggcctgt  ggcgccgtg  tcgcctttg  catcctgat  gccatcgtc  1740
gctacatta  ccagacacg  aggaaaaag  acgtgacag  gagccccag  ttctcggca  1800
gggacaacc  tcccgtcct  ttcagcagc  acttccgca  ctctggggc  ccagagaag  1860
acgagtcca  agaggtttc  accctggaa  ctcactgag  gccccagga  agcgagagg  1920
gcctgggat  tgagaggag  ctgctgggc  ttcggggtg  gcccccaga  ctggacctg  1980
gctattctc  ctcggacct  gggaaacgg  ccaccaagg  cagctacac  ctgacggag  2040
agctagctg  gtatgctga  atccgggtc  agtgaagga  ctgggggca  cctgcgtgg  2100
tgacccccc  caggaccct  gctggcccc  actggctgt  ggctccctt  ctcccaaaa  2160
tatcggggg  tggggcagg  ggggagtga  gcaggtgac  gtgaggtcc  gggggcctg  2220
cctccccct  cttcccagc  gcccctccc  gccagcacc  ccacgccct  attacggct  2280
ctctctaac  tcctttacc  tcatctgtc  ggaggggag  tctgtctgt  cgtgttatt  2340
attgctact  cctgcctgg  ctcctgccc  cacacctgg  cctggggcc  gtacaaaag  2400
gacatgaaa  aaatgcccc  aagcc  2425



<210> 3433
<211> 626
<212> PRT
<213> Homo sapiens
<308> P20916
<400> 3433

Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
  1               5                  10                  15
Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
             20                  25                  30
Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
         35                  40                  45
Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
     50                  55                  60
Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
 65                  70                  75                  80
Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                 85                  90                  95
Leu Arg Asn Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly 
             100                105                110
Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
         115                120                125
Phe Ser Glu His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val 
     130                135                140
Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met 
 145                150                155                160
Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly 
                 165                170                175
His Glu Gly Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp 
             180                185                190
Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg 
         195                200                205
Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr 
     210                215                220
Thr Leu Gln Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro 
 225                230                235                240
Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His 
                 245                250                255
Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr 
             260                265                270
Trp Met Arg Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu 
         275                280                285
Leu Leu Glu Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala 
     290                295                300
Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu 
 305                310                315                320
Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val 
                 325                330                335
Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn 
             340                345                350
Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr 
         355                360                365
Val Ile Tyr Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro 
     370                375                380
Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln 
 385                390                395                400
Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu 
                 405                410                415
Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys 
             420                425                430
Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser 
         435                440                445
Arg Asn Val Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu 
     450                455                460
Arg Ser Gly Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala 
 465                470                475                480
Gln Ala Pro Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala 
                 485                490                495
Lys Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala 
             500                505                510
Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala 
         515                520                525
Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu 
     530                535                540
Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro Pro Val Leu Phe Ser Ser 
 545                550                555                560
Asp Phe Arg Ile Ser Gly Ala Pro Glu Lys Tyr Glu Ser Glu Arg Arg 
                 565                570                575
Leu Gly Ser Glu Arg Arg Leu Leu Gly Leu Arg Gly Glu Pro Pro Glu 
             580                585                590
Leu Asp Leu Ser Tyr Ser His Ser Asp Leu Gly Lys Arg Pro Thr Lys 
         595                600                605
Asp Ser Tyr Thr Leu Thr Glu Glu Leu Ala Glu Tyr Ala Glu Ile Arg 
     610                615                620
Val Lys 
 625



<210> 3434
<211> 2468
<212> DNA
<213> Rattus norvegicus
<308> M22357
<400> 3434

cagaagcca  accatccaa  gttgactgg  cacttggag  ggaatcagg  gacattccc  60
actcaggga  actgaggtg  gggccctag  tcgcccact  gctggacaa  atgatattc  120
ttaccaccc  gcctctgtt  tggataatg  tttcagctt  tcgaggggg  cactggggt  180
cctggatgc  ctcgtccat  tcagccttc  agggcacgt  tgtctccat  ccctgccgt  240
tcgacttcc  ggatgagct  agaccggct  tggtacatg  cgtctggta  ttcaacagt  300
cctacccca  gaactaccc  ccagtggtc  tcaagtccc  cacacaagt  gtccacgag  360
gcttccagg  ccgtagccg  ctgttggga  acctgggcc  acgaaactg  accctgctt  420
tcagcacgc  gagccctga  ctgggaggg  aatactatt  ccgaggtga  ctgggcggc  480
acaaccagt  caccttctc  gagcacagc  tcctggaca  catcaacac  cccaacatc  540
tggtgcccc  agaagtggt  gcaggaacg  aagtagagg  cagctgcat  gtgccggac  600
actgcccag  gctgcgccc  gagctgagc  ggctgggcc  cgaggggct  ggggagccc  660
ctgttctgg  tcggctgcg  gaggatgaa  gcacctggg  gcaggtgtc  ctgctacac  720
tcgtgccta  tagagaggc  aacggccac  gtctgggct  tcaggctgc  ttccccaac  780
ccaccttgc  gttcgaggg  tacgccagt  tggacgtca  gtacccccc  gtgattgtg  840
agatgaatt  ctctgtgga  gccattgag  gctcccatg  cagcctgct  tgtggggct  900
acagcaacc  gccaccgct  ctgacttgg  tgcgggatg  gatggtgtt  agggaggca  960
ttgctgaga  cctgtacct  gatctggag  aggtgaccc  agcagagga  ggcatctat  1020
cttgcctgg  agagaatgc  tatggccag  acaaccgca  ggtggagct  agcgtcatg  1080
atgcacctt  gaagcccac  gtgaatggg  cggtggtgg  ggtagaggg  gagacagtc  1140
ccatcctgt  ttccacaca  agcaacccg  accctattc  caccatctt  aaggagaag  1200
agatcctgg  cacggtcat  tatgagagt  agctgcagc  ggaactccc  gcagtgacg  1260
ccgaggacg  tggggagta  tggtgtgta  ctgagaacc  gtatggcca  agagccacc  1320
ccttcaacc  gtctgtgga  tttgctccc  taatccttc  ggaatcgca  tgtgcagcg  1380
ccagagaca  cgtgcagtg  ctgtgtgtg  taaaatcca  cccggaacc  tccgtggcc  1440
ttgagctgc  ttcccgcaa  gtgactgtg  acgagacag  gagggagtt  gtgtactca  1500
agcgcagcg  cctcctgct  accagcatc  tcacgctcc  gggtcaggc  caagcccca  1560
cccgcgtca  ttgtacctc  aggaacctc  acggcaccc  gagcctcga  ctgcctttc  1620
agggagcac  ccgactgat  tgggccaaa  tcggccctg  gggtgctgt  gtcgccttt  1680
ccatcctga  tgccattgt  tgctacatc  cccagacaa  aagaaaaaa  aacgtcaca  1740
agagcccca  cttctcagc  ggagacaac  ctcatgtcc  gtacagccc  gaattccga  1800
tctctggag  acctgataa  tatgagtcc  gagaggtct  tacccggga  tgtcactga  1860
agccccagg  gagtgagaa  cgcctgggg  ccgagagga  gctgctggg  cttaggggg  1920
aacccccag  actggacct  agttattcc  actcagacc  ggggaaacg  cccaccaag  1980
acagctaca  cctgacaga  gagctggct  agtacgcag  aatccgagt  aagtgagga  2040
gctgggggc  ggccctgtg  ctcaccccc  atcaggacc  tcgcttggc  cccactggc  2100
gtgggctcc  tttctcttg  gagtggtag  ggtgggggc  ggaaggggc  gggcaggaa  2160
cagtgaggt  ttaggggcc  ggcctcccc  ccttcccgg  tgctcctct  tgccaacat  2220
ctgcaccta  gttacagct  cctctcccc  ccttttaac  tcagctgtt  agaggggtg  2280
tctgtctgt  catgttatt  attgttatc  tggtctcct  tccccttac  cggccccag  2340
acctgtaca  aagggacat  aaataaatg  cctaatgac  agtgccagt  tagacccat  2400
ctttggagg  aaggggcat  ttagtaata  ttttctcgt  gctgtaaca  aatactgga  2460
aaaaacac  2468



<210> 3435
<211> 626
<212> PRT
<213> Rattus norvegicus
<308> P07722
<400> 3435

Met Ile Phe Leu Thr Thr Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
  1               5                  10                  15
Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
             20                  25                  30
Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
         35                  40                  45
Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
     50                  55                  60
Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
 65                  70                  75                  80
Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                 85                  90                  95
Leu Arg Asn Cys Thr Leu Leu Leu Ser Thr Leu Ser Pro Glu Leu Gly 
             100                105                110
Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
         115                120                125
Phe Ser Glu His Ser Val Leu Asp Ile Ile Asn Thr Pro Asn Ile Val 
     130                135                140
Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met 
 145                150                155                160
Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly 
                 165                170                175
His Glu Gly Leu Gly Glu Pro Thr Val Leu Gly Arg Leu Arg Glu Asp 
             180                185                190
Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg 
         195                200                205
Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ala Phe Pro Asn Thr 
     210                215                220
Thr Leu Gln Phe Glu Gly Tyr Ala Ser Leu Asp Val Lys Tyr Pro Pro 
 225                230                235                240
Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His 
                 245                250                255
Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr 
             260                265                270
Trp Met Arg Asp Gly Met Val Leu Arg Glu Ala Val Ala Glu Ser Leu 
         275                280                285
Tyr Leu Asp Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Ile Tyr Ala 
     290                295                300
Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Glu Leu 
 305                310                315                320
Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Val Val 
                 325                330                335
Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn 
             340                345                350
Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ala Thr 
         355                360                365
Val Ile Tyr Glu Ser Gln Leu Gln Leu Glu Leu Pro Ala Val Thr Pro 
     370                375                380
Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln 
 385                390                395                400
Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Ile Ile Leu 
                 405                410                415
Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys 
             420                425                430
Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser 
         435                440                445
Arg Asn Val Thr Val Asn Glu Thr Glu Arg Glu Phe Val Tyr Ser Glu 
     450                455                460
Arg Ser Gly Leu Leu Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala 
 465                470                475                480
Gln Ala Pro Pro Arg Val Ile Cys Thr Ser Arg Asn Leu Tyr Gly Thr 
                 485                490                495
Gln Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala 
             500                505                510
Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala 
         515                520                525
Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu 
     530                535                540
Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro His Val Leu Tyr Ser Pro 
 545                550                555                560
Glu Phe Arg Ile Ser Gly Ala Pro Asp Lys Tyr Glu Ser Glu Lys Arg 
                 565                570                575
Leu Gly Ser Glu Arg Arg Leu Leu Gly Leu Arg Gly Glu Pro Pro Glu 
             580                585                590
Leu Asp Leu Ser Tyr Ser His Ser Asp Leu Gly Lys Arg Pro Thr Lys 
         595                600                605
Asp Ser Tyr Thr Leu Thr Glu Glu Leu Ala Glu Tyr Ala Glu Ile Arg 
     610                615                620
Val Lys 
 625



<210> 3436
<211> 2425
<212> DNA
<213> Homo sapiens
<308> NM_080600
<400> 3436

ctagaccct  gaaggcagg  gactgcgag  tgggctggc  gagcagagg  gcagaagca  60
ctgagtcca  gttgtctgg  ggcttcagg  ggacccaga  gacgtcccc  actcaggga  120
attcagcga  cactcactc  ctgtacaga  tgatattcc  cacggcact  cctctgttc  180
ggattatga  ttcagcctc  cgagggggt  actggggtg  ctggatgcc  tcgtccatc  240
cggccttcg  aggcacgtg  gtctccatc  cctgccgct  tgacttccc  gatgagctg  300
ggcccgctg  ggtgcatgg  gtctggtac  tcaatagcc  ctaccccaa  aactacccc  360
cggtggtct  caagtcgcg  acccaagta  tccacgaga  cttccaggg  cgcagccgc  420
tcctggggg  cctgggcct  cgaaactgc  ccctcctgc  cagcaacgt  agccccgag  480
tgggcggga  gtactactt  cgtggggac  tgggcggct  caaccagta  accttctca  540
agcacagcg  cctggatat  gtcaacacc  ccaacatcg  ggtgccccc  gaggtggtg  600
caggcacgg  ggtggaggt  agctgcatg  tgccggaca  ctgcccaga  ctgcgccct  660
agctgagct  gctgggcca  gaggggctg  gggagcccg  tgtgctggg  cggctgcgg  720
aggacgagg  cacctgggt  caggtgtca  tgctgcact  cgtgcccac  agggaggcc  780
acggccaca  gctgggctg  caggcctcc  tccccaaca  caccctgca  ttcgagggc  840
acgccagca  ggacgtcaa  taccccccg  tgattgtgg  gatgaactc  tcggtggag  900
ccatcgagg  ctcccacgt  agcctgctc  gtggggctg  cagcaaccc  ccgccgctg  960
tgacctgga  gcgggacgg  acagtcctc  gggaggcgg  ggccgagag  ctgctcctg  1020
agctggagg  ggtgacccc  gccgaagac  gcgtctatg  ctgcctggc  gagaatgcc  1080
atggccagg  caaccgcac  gtggggctc  gtgtcatgt  tgcaccctg  aagccaaca  1140
tgaacggga  aatggtggc  gtagagggg  agacggtct  tatcttgtg  tccacacag  1200
gcaacccgg  ccctattct  accatcttc  aggagaagc  gatcctgtc  acggtcatc  1260
acgagagcg  gctgcagct  gagctgccg  ccgtgtcac  cgaggatga  ggagagtac  1320
ggtgtgtgg  tgagaacca  tatggccag  gggccaccg  cttcaacct  tctgtggag  1380
tcgcccctg  gctcctcct  gagtcccac  gcgcggcag  ccgagacac  gtgcagtgc  1440
tgtgcgtgg  gaagtccaa  ccggagccg  ccgtggcct  tgagctgcc  tcgcgcaat  1500
tgaccgtga  cgagagcga  cgggagttc  tgtactcgg  gcgcagcgg  ctcgtgctc  1560
ccagcatcc  cacgctgcg  gggcaggcc  aggccccgc  ccgcgtcat  tgcaccgcg  1620
ggaacctct  tggcgccaa  agcctggag  tgcccttcc  gggagccca  cgactgatg  1680
gggccaaga  cgggcctgt  ggcgccgtg  tcgcctttg  catcctgat  gccatcgtc  1740
gctacatta  ccagacacg  aggaaaaag  acgtgacag  gagccccag  ttctcggca  1800
gggacaacc  tcccgtcct  ttcagcagc  acttccgca  ctctggggc  ccagagaag  1860
acgagtcca  agaggtttc  accctggaa  ctcactgag  gccccagga  agcgagagg  1920
gcctgggat  tgagaggag  ctgctgggc  ttcggggtg  gcccccaga  ctggacctg  1980
gctattctc  ctcggacct  gggaaacgg  ccaccaagg  cagctacac  ctgacggag  2040
agctagctg  gtatgctga  atccgggtc  agtgaagga  ctgggggca  cctgcgtgg  2100
tgacccccc  caggaccct  gctggcccc  actggctgt  ggctccctt  ctcccaaaa  2160
tatcggggg  tggggcagg  ggggagtga  gcaggtgac  gtgaggtcc  gggggcctg  2220
cctccccct  cttcccagc  gcccctccc  gccagcacc  ccacgccct  attacggct  2280
ctctctaac  tcctttacc  tcatctgtc  ggaggggag  tctgtctgt  cgtgttatt  2340
attgctact  cctgcctgg  ctcctgccc  cacacctgg  cctggggcc  gtacaaaag  2400
gacatgaaa  aaatgcccc  aagcc  2425



<210> 3437
<211> 626
<212> PRT
<213> Homo sapiens
<308> P20916
<400> 3437

Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
  1               5                  10                  15
Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
             20                  25                  30
Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
         35                  40                  45
Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
     50                  55                  60
Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
 65                  70                  75                  80
Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                 85                  90                  95
Leu Arg Asn Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly 
             100                105                110
Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
         115                120                125
Phe Ser Glu His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val 
     130                135                140
Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met 
 145                150                155                160
Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly 
                 165                170                175
His Glu Gly Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp 
             180                185                190
Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg 
         195                200                205
Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr 
     210                215                220
Thr Leu Gln Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro 
 225                230                235                240
Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His 
                 245                250                255
Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr 
             260                265                270
Trp Met Arg Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu 
         275                280                285
Leu Leu Glu Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala 
     290                295                300
Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu 
 305                310                315                320
Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val 
                 325                330                335
Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn 
             340                345                350
Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr 
         355                360                365
Val Ile Tyr Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro 
     370                375                380
Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln 
 385                390                395                400
Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu 
                 405                410                415
Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys 
             420                425                430
Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser 
         435                440                445
Arg Asn Val Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu 
     450                455                460
Arg Ser Gly Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala 
 465                470                475                480
Gln Ala Pro Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala 
                 485                490                495
Lys Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala 
             500                505                510
Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala 
         515                520                525
Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu 
     530                535                540
Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro Pro Val Leu Phe Ser Ser 
 545                550                555                560
Asp Phe Arg Ile Ser Gly Ala Pro Glu Lys Tyr Glu Ser Glu Arg Arg 
                 565                570                575
Leu Gly Ser Glu Arg Arg Leu Leu Gly Leu Arg Gly Glu Pro Pro Glu 
             580                585                590
Leu Asp Leu Ser Tyr Ser His Ser Asp Leu Gly Lys Arg Pro Thr Lys 
         595                600                605
Asp Ser Tyr Thr Leu Thr Glu Glu Leu Ala Glu Tyr Ala Glu Ile Arg 
     610                615                620
Val Lys 
 625



<210> 3438
<211> 2468
<212> DNA
<213> Rattus norvegicus
<308> M22357
<400> 3438

cagaagcca  accatccaa  gttgactgg  cacttggag  ggaatcagg  gacattccc  60
actcaggga  actgaggtg  gggccctag  tcgcccact  gctggacaa  atgatattc  120
ttaccaccc  gcctctgtt  tggataatg  tttcagctt  tcgaggggg  cactggggt  180
cctggatgc  ctcgtccat  tcagccttc  agggcacgt  tgtctccat  ccctgccgt  240
tcgacttcc  ggatgagct  agaccggct  tggtacatg  cgtctggta  ttcaacagt  300
cctacccca  gaactaccc  ccagtggtc  tcaagtccc  cacacaagt  gtccacgag  360
gcttccagg  ccgtagccg  ctgttggga  acctgggcc  acgaaactg  accctgctt  420
tcagcacgc  gagccctga  ctgggaggg  aatactatt  ccgaggtga  ctgggcggc  480
acaaccagt  caccttctc  gagcacagc  tcctggaca  catcaacac  cccaacatc  540
tggtgcccc  agaagtggt  gcaggaacg  aagtagagg  cagctgcat  gtgccggac  600
actgcccag  gctgcgccc  gagctgagc  ggctgggcc  cgaggggct  ggggagccc  660
ctgttctgg  tcggctgcg  gaggatgaa  gcacctggg  gcaggtgtc  ctgctacac  720
tcgtgccta  tagagaggc  aacggccac  gtctgggct  tcaggctgc  ttccccaac  780
ccaccttgc  gttcgaggg  tacgccagt  tggacgtca  gtacccccc  gtgattgtg  840
agatgaatt  ctctgtgga  gccattgag  gctcccatg  cagcctgct  tgtggggct  900
acagcaacc  gccaccgct  ctgacttgg  tgcgggatg  gatggtgtt  agggaggca  960
ttgctgaga  cctgtacct  gatctggag  aggtgaccc  agcagagga  ggcatctat  1020
cttgcctgg  agagaatgc  tatggccag  acaaccgca  ggtggagct  agcgtcatg  1080
atgcacctt  gaagcccac  gtgaatggg  cggtggtgg  ggtagaggg  gagacagtc  1140
ccatcctgt  ttccacaca  agcaacccg  accctattc  caccatctt  aaggagaag  1200
agatcctgg  cacggtcat  tatgagagt  agctgcagc  ggaactccc  gcagtgacg  1260
ccgaggacg  tggggagta  tggtgtgta  ctgagaacc  gtatggcca  agagccacc  1320
ccttcaacc  gtctgtgga  tttgctccc  taatccttc  ggaatcgca  tgtgcagcg  1380
ccagagaca  cgtgcagtg  ctgtgtgtg  taaaatcca  cccggaacc  tccgtggcc  1440
ttgagctgc  ttcccgcaa  gtgactgtg  acgagacag  gagggagtt  gtgtactca  1500
agcgcagcg  cctcctgct  accagcatc  tcacgctcc  gggtcaggc  caagcccca  1560
cccgcgtca  ttgtacctc  aggaacctc  acggcaccc  gagcctcga  ctgcctttc  1620
agggagcac  ccgactgat  tgggccaaa  tcggccctg  gggtgctgt  gtcgccttt  1680
ccatcctga  tgccattgt  tgctacatc  cccagacaa  aagaaaaaa  aacgtcaca  1740
agagcccca  cttctcagc  ggagacaac  ctcatgtcc  gtacagccc  gaattccga  1800
tctctggag  acctgataa  tatgagtcc  gagaggtct  tacccggga  tgtcactga  1860
agccccagg  gagtgagaa  cgcctgggg  ccgagagga  gctgctggg  cttaggggg  1920
aacccccag  actggacct  agttattcc  actcagacc  ggggaaacg  cccaccaag  1980
acagctaca  cctgacaga  gagctggct  agtacgcag  aatccgagt  aagtgagga  2040
gctgggggc  ggccctgtg  ctcaccccc  atcaggacc  tcgcttggc  cccactggc  2100
gtgggctcc  tttctcttg  gagtggtag  ggtgggggc  ggaaggggc  gggcaggaa  2160
cagtgaggt  ttaggggcc  ggcctcccc  ccttcccgg  tgctcctct  tgccaacat  2220
ctgcaccta  gttacagct  cctctcccc  ccttttaac  tcagctgtt  agaggggtg  2280
tctgtctgt  catgttatt  attgttatc  tggtctcct  tccccttac  cggccccag  2340
acctgtaca  aagggacat  aaataaatg  cctaatgac  agtgccagt  tagacccat  2400
ctttggagg  aaggggcat  ttagtaata  ttttctcgt  gctgtaaca  aatactgga  2460
aaaaacac  2468



<210> 3439
<211> 626
<212> PRT
<213> Rattus norvegicus
<308> P07722
<400> 3439

Met Ile Phe Leu Thr Thr Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
  1               5                  10                  15
Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
             20                  25                  30
Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
         35                  40                  45
Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
     50                  55                  60
Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
 65                  70                  75                  80
Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                 85                  90                  95
Leu Arg Asn Cys Thr Leu Leu Leu Ser Thr Leu Ser Pro Glu Leu Gly 
             100                105                110
Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
         115                120                125
Phe Ser Glu His Ser Val Leu Asp Ile Ile Asn Thr Pro Asn Ile Val 
     130                135                140
Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met 
 145                150                155                160
Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly 
                 165                170                175
His Glu Gly Leu Gly Glu Pro Thr Val Leu Gly Arg Leu Arg Glu Asp 
             180                185                190
Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg 
         195                200                205
Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ala Phe Pro Asn Thr 
     210                215                220
Thr Leu Gln Phe Glu Gly Tyr Ala Ser Leu Asp Val Lys Tyr Pro Pro 
 225                230                235                240
Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His 
                 245                250                255
Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr 
             260                265                270
Trp Met Arg Asp Gly Met Val Leu Arg Glu Ala Val Ala Glu Ser Leu 
         275                280                285
Tyr Leu Asp Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Ile Tyr Ala 
     290                295                300
Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Glu Leu 
 305                310                315                320
Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Val Val 
                 325                330                335
Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn 
             340                345                350
Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ala Thr 
         355                360                365
Val Ile Tyr Glu Ser Gln Leu Gln Leu Glu Leu Pro Ala Val Thr Pro 
     370                375                380
Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln 
 385                390                395                400
Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Ile Ile Leu 
                 405                410                415
Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys 
             420                425                430
Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser 
         435                440                445
Arg Asn Val Thr Val Asn Glu Thr Glu Arg Glu Phe Val Tyr Ser Glu 
     450                455                460
Arg Ser Gly Leu Leu Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala 
 465                470                475                480
Gln Ala Pro Pro Arg Val Ile Cys Thr Ser Arg Asn Leu Tyr Gly Thr 
                 485                490                495
Gln Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala 
             500                505                510
Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala 
         515                520                525
Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu 
     530                535                540
Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro His Val Leu Tyr Ser Pro 
 545                550                555                560
Glu Phe Arg Ile Ser Gly Ala Pro Asp Lys Tyr Glu Ser Glu Lys Arg 
                 565                570                575
Leu Gly Ser Glu Arg Arg Leu Leu Gly Leu Arg Gly Glu Pro Pro Glu 
             580                585                590
Leu Asp Leu Ser Tyr Ser His Ser Asp Leu Gly Lys Arg Pro Thr Lys 
         595                600                605
Asp Ser Tyr Thr Leu Thr Glu Glu Leu Ala Glu Tyr Ala Glu Ile Arg 
     610                615                620
Val Lys 
 625



<210> 3440
<211> 2425
<212> DNA
<213> Homo sapiens
<308> NM_080600
<400> 3440

ctagaccct  gaaggcagg  gactgcgag  tgggctggc  gagcagagg  gcagaagca  60
ctgagtcca  gttgtctgg  ggcttcagg  ggacccaga  gacgtcccc  actcaggga  120
attcagcga  cactcactc  ctgtacaga  tgatattcc  cacggcact  cctctgttc  180
ggattatga  ttcagcctc  cgagggggt  actggggtg  ctggatgcc  tcgtccatc  240
cggccttcg  aggcacgtg  gtctccatc  cctgccgct  tgacttccc  gatgagctg  300
ggcccgctg  ggtgcatgg  gtctggtac  tcaatagcc  ctaccccaa  aactacccc  360
cggtggtct  caagtcgcg  acccaagta  tccacgaga  cttccaggg  cgcagccgc  420
tcctggggg  cctgggcct  cgaaactgc  ccctcctgc  cagcaacgt  agccccgag  480
tgggcggga  gtactactt  cgtggggac  tgggcggct  caaccagta  accttctca  540
agcacagcg  cctggatat  gtcaacacc  ccaacatcg  ggtgccccc  gaggtggtg  600
caggcacgg  ggtggaggt  agctgcatg  tgccggaca  ctgcccaga  ctgcgccct  660
agctgagct  gctgggcca  gaggggctg  gggagcccg  tgtgctggg  cggctgcgg  720
aggacgagg  cacctgggt  caggtgtca  tgctgcact  cgtgcccac  agggaggcc  780
acggccaca  gctgggctg  caggcctcc  tccccaaca  caccctgca  ttcgagggc  840
acgccagca  ggacgtcaa  taccccccg  tgattgtgg  gatgaactc  tcggtggag  900
ccatcgagg  ctcccacgt  agcctgctc  gtggggctg  cagcaaccc  ccgccgctg  960
tgacctgga  gcgggacgg  acagtcctc  gggaggcgg  ggccgagag  ctgctcctg  1020
agctggagg  ggtgacccc  gccgaagac  gcgtctatg  ctgcctggc  gagaatgcc  1080
atggccagg  caaccgcac  gtggggctc  gtgtcatgt  tgcaccctg  aagccaaca  1140
tgaacggga  aatggtggc  gtagagggg  agacggtct  tatcttgtg  tccacacag  1200
gcaacccgg  ccctattct  accatcttc  aggagaagc  gatcctgtc  acggtcatc  1260
acgagagcg  gctgcagct  gagctgccg  ccgtgtcac  cgaggatga  ggagagtac  1320
ggtgtgtgg  tgagaacca  tatggccag  gggccaccg  cttcaacct  tctgtggag  1380
tcgcccctg  gctcctcct  gagtcccac  gcgcggcag  ccgagacac  gtgcagtgc  1440
tgtgcgtgg  gaagtccaa  ccggagccg  ccgtggcct  tgagctgcc  tcgcgcaat  1500
tgaccgtga  cgagagcga  cgggagttc  tgtactcgg  gcgcagcgg  ctcgtgctc  1560
ccagcatcc  cacgctgcg  gggcaggcc  aggccccgc  ccgcgtcat  tgcaccgcg  1620
ggaacctct  tggcgccaa  agcctggag  tgcccttcc  gggagccca  cgactgatg  1680
gggccaaga  cgggcctgt  ggcgccgtg  tcgcctttg  catcctgat  gccatcgtc  1740
gctacatta  ccagacacg  aggaaaaag  acgtgacag  gagccccag  ttctcggca  1800
gggacaacc  tcccgtcct  ttcagcagc  acttccgca  ctctggggc  ccagagaag  1860
acgagtcca  agaggtttc  accctggaa  ctcactgag  gccccagga  agcgagagg  1920
gcctgggat  tgagaggag  ctgctgggc  ttcggggtg  gcccccaga  ctggacctg  1980
gctattctc  ctcggacct  gggaaacgg  ccaccaagg  cagctacac  ctgacggag  2040
agctagctg  gtatgctga  atccgggtc  agtgaagga  ctgggggca  cctgcgtgg  2100
tgacccccc  caggaccct  gctggcccc  actggctgt  ggctccctt  ctcccaaaa  2160
tatcggggg  tggggcagg  ggggagtga  gcaggtgac  gtgaggtcc  gggggcctg  2220
cctccccct  cttcccagc  gcccctccc  gccagcacc  ccacgccct  attacggct  2280
ctctctaac  tcctttacc  tcatctgtc  ggaggggag  tctgtctgt  cgtgttatt  2340
attgctact  cctgcctgg  ctcctgccc  cacacctgg  cctggggcc  gtacaaaag  2400
gacatgaaa  aaatgcccc  aagcc  2425



<210> 3441
<211> 626
<212> PRT
<213> Homo sapiens
<308> P20916
<400> 3441

Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
  1               5                  10                  15
Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
             20                  25                  30
Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
         35                  40                  45
Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
     50                  55                  60
Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
 65                  70                  75                  80
Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                 85                  90                  95
Leu Arg Asn Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly 
             100                105                110
Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
         115                120                125
Phe Ser Glu His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val 
     130                135                140
Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met 
 145                150                155                160
Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly 
                 165                170                175
His Glu Gly Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp 
             180                185                190
Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg 
         195                200                205
Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr 
     210                215                220
Thr Leu Gln Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro 
 225                230                235                240
Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His 
                 245                250                255
Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr 
             260                265                270
Trp Met Arg Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu 
         275                280                285
Leu Leu Glu Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala 
     290                295                300
Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu 
 305                310                315                320
Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val 
                 325                330                335
Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn 
             340                345                350
Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr 
         355                360                365
Val Ile Tyr Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro 
     370                375                380
Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln 
 385                390                395                400
Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu 
                 405                410                415
Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys 
             420                425                430
Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser 
         435                440                445
Arg Asn Val Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu 
     450                455                460
Arg Ser Gly Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala 
 465                470                475                480
Gln Ala Pro Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala 
                 485                490                495
Lys Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala 
             500                505                510
Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala 
         515                520                525
Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu 
     530                535                540
Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro Pro Val Leu Phe Ser Ser 
 545                550                555                560
Asp Phe Arg Ile Ser Gly Ala Pro Glu Lys Tyr Glu Ser Glu Arg Arg 
                 565                570                575
Leu Gly Ser Glu Arg Arg Leu Leu Gly Leu Arg Gly Glu Pro Pro Glu 
             580                585                590
Leu Asp Leu Ser Tyr Ser His Ser Asp Leu Gly Lys Arg Pro Thr Lys 
         595                600                605
Asp Ser Tyr Thr Leu Thr Glu Glu Leu Ala Glu Tyr Ala Glu Ile Arg 
     610                615                620
Val Lys 
 625



<210> 3442
<211> 2213
<212> DNA
<213> Rattus norvegicus
<308> M22400
<400> 3442

ggtagcggc  cgtctcttg  tctgcaagg  tactgccag  cttgctgag  ctcgggacc  60
ctccggctc  tattgccac  ctctcgtgc  ctcctcgct  ccccaagaa  caggatggc  120
gggaccgtg  gcaccgcgt  cttgctggt  gcgatgctg  tcggcttgg  ctgcctggg  180
caggcgcag  ccccgccgc  tccagacgc  acctgtcac  aggtccgtt  tttcttcca  240
agactgcag  ccggactca  atgggttcc  gaaacccct  tgccaggat  agatttgca  300
gtatgtctc  ccaagggcc  aacatgctg  tcaagaaag  tggaagaaa  ataccaact  360
acagcgcgc  tgaacatgg  acaactgct  cagtctgcg  gtatggaac  caagttctt  420
attattcag  atgctgcgg  tttccaaga  gcctttgaa  ttgttgttc  ccatgccaa  480
aactacacc  atgccatgt  caagaataa  taccccagc  tgactccac  agcttttga  540
tttgtcggt  aatttttca  agatgtgtc  ctctacatc  tgggttctg  tatcaatgt  600
gatgatatg  tcaatgaat  gttcgacag  ctctttcca  tcatctata  ccagatgat  660
aacccaggc  tccccgagt  agtattaga  atcaacgag  gcctccgag  agcaagacg  720
gacctgaaa  tatttggca  tttccccaa  cttattatg  cccaggttt  caagtcact  780
caagttact  gaatcttcc  tcaggccct  aacctcgga  ttgaagtaa  caacaccac  840
gaccacctc  agtttagta  ggactgtgg  cgtatgctc  cccgaatgt  gtactgctc  900
tactgccag  gactgatga  ggtcaaacc  tgtggtggt  attgcaatg  ggtcatgca  960
ggctgtatg  caggtgtgg  agagatcga  aagtactgg  gagaataca  tctgtctct  1020
gaagagctc  tgaacggca  gtacagaat  tacgacatg  agaatgtgc  gctcggact  1080
ttttcaacc  tccatgatt  catccagta  gtgcagaag  acggaggca  gctgaccac  1140
actattggc  agttgtgcg  ccactccca  caacgccaa  atagatctg  ttattatcc  1200
gaagatctg  ttattgaca  gaaggtatt  aaagtcgcc  gtgtcgaac  tgaagaaac  1260
ttatccagc  gaagaaggg  actgattca  aagttgaag  ctttcatca  cttctatag  1320
gctttgcca  gctacatct  cagccatag  cccgtggcc  aaaacgaca  cctgtgctg  1380
aacggacaa  agcttgtgg  gagatacag  cagaaggcg  caaggaatg  gatgaagaa  1440
cagtttaac  tccatgagc  gaaaatgaa  ggccctgag  cagtggtta  ccagatcat  1500
gacaaactg  agcacatta  ccagctcct  agaaccatg  ctgtgccca  gggtaaagt  1560
gtggataaa  gcctggatg  ggaaggact  gagagtgga  actgtggtg  tgatgagga  1620
gagtgcatc  ggagctctg  tgacggcat  atgaaagtg  agaaccaac  gcgcttcct  1680
gcagaactg  catatgatc  ggatgtgga  gatgctcca  ggaacaagc  acatggaaa  1740
cagaaggac  acgagatca  cacctctca  agcgtgggg  acatgccat  cccactgaa  1800
atcctcatc  gtgtggcca  ctacgtggc  tgctttttt  cctggtgca  tgacttgcc  1860
tgcccatgc  tgtgctgcc  tgcagcacc  tgtggccct  ctacataaa  ggagccacc  1920
tcctttttc  tttcttttt  ttttttacc  tgtatgcct  ctctcaccg  cattaagta  1980
gagactaac  acgtgttat  ttttcgaaa  tcaaatggt  tctttatga  gaaggtaaa  2040
tttagtggt  ggatagatt  tcttttttg  aaaaaaaaa  aaacaaaaa  aattcaagt  2100
gtgccaaat  attttctta  atttgactg  tggaacatg  ttgtcatgg  ttccctctt  2160
tctctttct  tgcatggat  tctttgaca  aaaaaataa  taaacattc  aat  2213



<210> 3443
<211> 597
<212> PRT
<213> Rattus norvegicus
<308> P13265
<400> 3443

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Leu Val Ala Met Leu Leu 
  1               5                  10                  15
Gly Leu Gly Cys Leu Gly Gln Ala Gln Pro Pro Pro Pro Pro Asp Ala 
             20                  25                  30
Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly Leu 
         35                  40                  45
Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val Cys 
     50                  55                  60
Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys Tyr 
 65                  70                  75                  80
Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala Ser 
                 85                  90                  95
Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln Glu 
             100                105                110
Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala Met 
         115                120                125
Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe Val 
     130                135                140
Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp Ile 
 145                150                155                160
Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro Val 
                 165                170                175
Ile Tyr Thr Gln Met Met Asn Pro Gly Leu Pro Glu Ser Val Leu Asp 
             180                185                190
Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe Gly 
         195                200                205
Ser Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln Val 
     210                215                220
Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile Asn 
 225                230                235                240
Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu Thr 
                 245                250                255
Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys Pro 
             260                265                270
Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly Val 
         275                280                285
Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu Glu 
     290                295                300
Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu Leu 
 305                310                315                320
Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys Asn 
                 325                330                335
Gly Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser Gln 
             340                345                350
Gln Arg Gln Tyr Arg Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile Asp 
         355                360                365
Lys Lys Val Leu Lys Val Ala Arg Val Glu His Glu Glu Thr Leu Ser 
     370                375                380
Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser Phe 
 385                390                395                400
Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala Glu 
                 405                410                415
Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr Ser 
             420                425                430
Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His Glu 
         435                440                445
Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp Lys 
     450                455                460
Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Val Pro Lys Gly 
 465                470                475                480
Lys Val Val Asp Lys Ser Leu Asp Glu Glu Gly Leu Glu Ser Gly Asp 
                 485                490                495
Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Ser Ser Gly Asp Gly Met 
             500                505                510
Met Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr Asp 
         515                520                525
Leu Asp Val Asp Asp Ala Pro Gly Asn Lys Gln His Gly Asn Gln Lys 
     530                535                540
Asp Asn Glu Ile Thr Thr Ser His Ser Val Gly Asn Met Pro Ser Pro 
 545                550                555                560
Leu Lys Ile Leu Ile Ser Val Ala Ile Tyr Val Ala Cys Phe Phe Ser 
                 565                570                575
Trp Cys Thr Asp Leu Pro Cys Pro Cys Leu Cys Cys Pro Ala Ala Pro 
             580                585                590
Cys Gly Pro Pro Thr 
         595



<210> 3444
<211> 2130
<212> DNA
<213> Homo sapiens
<308> L47125
<400> 3444

gcgcccagg  agctgcgag  aaacttttg  agcggctgg  tagcagcac  tctcttgct  60
ctcagggcc  ctgccaggc  tgccgagtc  tgggactgc  ctcgctccg  ctgccactc  120
cccgcgctc  cctagctcc  tgcgaagca  gatggccgg  accgtgcgc  ccgcgtgct  180
ggtggtggc  atgctgctc  gcttggact  cccgggaca  gcgcagccc  cgccgccgc  240
gccggacgc  acctgtcac  aagtccgct  cttcttcca  agactgcag  ccggactca  300
gtgggtgcc  gaaactccc  tgccaggat  agatttgca  gtatgtctc  ctaagggcc  360
aacatgctg  tcaagaaag  tggaagaaa  ataccaact  acagcacga  tgaacatgg  420
acagctgct  cagtctgca  gtatggagc  caagttctt  attattcag  atgctgcgg  480
tttccaaga  gcctttgaa  ttgttgttc  ccatgccaa  aactacacc  atgccatgt  540
caagaacaa  tacccaagc  tgactccac  agcttttga  tttgtgggt  aatttttca  600
agatgtgtc  ctctacatc  tgggttctg  catcaatgt  gatgacatg  tcaatgaat  660
gtttgacag  ctgtttcca  tcatctata  ccagctaat  aacccaggc  tgcctgatt  720
agccttgga  atcaatgag  gcctccgag  agcaagacg  gacctgaaa  tatttggga  780
tttccccaa  cttattatg  cccaggttt  caagtcact  caagtcact  ggatcttcc  840
tcaggctct  aatcttgga  ttgaagtga  caacacaac  gatcacctg  agttcagta  900
ggactgtgg  cgaatgctc  ccagaatgt  gtactgctc  tactgccag  gactgatga  960
ggttaaacc  tgtggcggt  actgcaatg  ggtcatgca  ggctgtatg  caggtgtgg  1020
ggagattga  aagtactgg  gagaataca  tctgtccct  gaagaactt  tgaatggca  1080
gtacagaat  tatgacatg  agaacgtac  gcttggtct  ttttcaaca  tccatgatt  1140
tatccagta  gtccagaag  atgcaggaa  gctgaccac  actattggc  agttatgtg  1200
ccattctca  caacgccaa  atagatctg  ttattatcc  gaagatctc  ttattgaca  1260
gaaagtatt  aaagttgct  atgtagaac  tgaagaaac  ttatccagc  gaagaaggg  1320
actaattca  aagttgaag  ctttcatca  cttctatag  gctttgcct  gctacatct  1380
cagccatag  cctgtggcg  aaaacgaca  cctttgctg  aatggacaa  aactcgtgg  1440
gagatacag  caaaaggca  caaggaatg  aatgaaaaa  cagttcaat  tccatgagc  1500
gaaaatgaa  ggccctgag  cagtggtca  tcaaattat  gacaaactg  agcacatta  1560
ccagctcct  agaaccatg  ctatgccca  aggtagagt  ctggataaa  acctggatg  1620
ggaagggtt  gaaagtgga  actgcggtg  tgatgaaga  gagtgcatt  gaggctctg  1680
tgatggaat  ataaaagtg  agaatcagc  ccgcttcct  gcagaactg  cctatgatc  1740
ggatgtgga  gatgcgcct  gaaacagtc  gcaggcaac  ccgaaggac  acgagataa  1800
cacctttca  aacctcggg  acgttcatt  cccgctgaa  cttctcacc  gcatggcca  1860
ctcggtggt  tgcttcttc  tcctggtgc  ctgactgcc  ggtgcccag  acatgtgct  1920
ccctacagc  ccctgtggt  ttcctcgat  aagggaacc  ctttcttat  tttttctat  1980
ttttttttt  tgttatcct  tatacctcc  ccagccatg  agtagagga  taaccatgt  2040
ttatgtttt  gaaaatcaa  tggtatctt  tggaggaag  tacatttta  tggtagcat  2100
tagattgtc  ttttgcaaa  aaaaaaaccg  2130



<210> 3445
<211> 580
<212> PRT
<213> Homo sapiens
<308> P51654
<400> 3445

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
  1               5                  10                  15
Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
             20                  25                  30
Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
         35                  40                  45
Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
     50                  55                  60
Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
 65                  70                  75                  80
Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                 85                  90                  95
Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
             100                105                110
Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
         115                120                125
Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
     130                135                140
Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
 145                150                155                160
Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                 165                170                175
Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
             180                185                190
Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
         195                200                205
Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
     210                215                220
Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
 225                230                235                240
Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                 245                250                255
Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
             260                265                270
Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
         275                280                285
Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
     290                295                300
Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
 305                310                315                320
Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                 325                330                335
Asn Ala Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser 
             340                345                350
Gln Gln Arg Gln Tyr Arg Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile 
         355                360                365
Asp Lys Lys Val Leu Lys Val Ala His Val Glu His Glu Glu Thr Leu 
     370                375                380
Ser Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser 
 385                390                395                400
Phe Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala 
                 405                410                415
Glu Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr 
             420                425                430
Ser Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His 
         435                440                445
Glu Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp 
     450                455                460
Lys Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Met Pro Lys 
 465                470                475                480
Gly Arg Val Leu Asp Lys Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly 
                 485                490                495
Asp Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly 
             500                505                510
Met Ile Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr 
         515                520                525
Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser Gln Gln Ala Thr Pro 
     530                535                540
Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val His Ser 
 545                550                555                560
Pro Leu Lys Leu Leu Thr Ser Met Ala Ile Ser Val Val Cys Phe Phe 
                 565                570                575
Phe Leu Val His 
             580



<210> 3446
<211> 250
<212> DNA
<213> Rattus norvegicus
<308> M23566
<400> 3446

cttaatttt  tcttctttc  actaccaca  attatggaa  tgcctcagg  cgcagtgaa  60
aagaagtgt  tcgccagag  cctgacctc  ggacttccc  agaaaaaca  tgtatttgt  120
tttccagag  tttgatcaa  aaaccattt  tttcatatc  acccatcac  attccctca  180
taattcagt  atcattttt  tacattttc  tgcttccac  tctagtact  aataaaaac  240
gatgaaaatc  250



<210> 3447
<211> 1472
<212> PRT
<213> Rattus norvegicus
<308> A26122
<400> 3447

Met Gly Lys His Arg Leu Arg Ser Leu Ala Leu Leu Pro Leu Leu Leu 
  1               5                  10                  15
Arg Leu Leu Leu Leu Leu Leu Pro Thr Asp Ala Ser Ala Pro Gln Lys 
             20                  25                  30
Pro Ile Tyr Met Val Met Val Pro Ser Leu Leu His Ala Gly Thr Pro 
         35                  40                  45
Glu Lys Ala Cys Phe Leu Phe Ser His Leu Asn Glu Thr Val Ala Val 
     50                  55                  60
Arg Val Ser Leu Glu Ser Val His Gly Asn Gln Ser Leu Phe Thr Asp 
 65                  70                  75                  80
Leu Val Val Asp Lys Asp Leu Phe His Cys Thr Ser Phe Thr Val Pro 
                 85                  90                  95
Gln Ser Ser Ser Asp Glu Leu Met Phe Phe Thr Val Gln Val Lys Gly 
             100                105                110
Ala Thr His Glu Phe Arg Arg Gln Ser Thr Val Leu Val Lys Lys Lys 
         115                120                125
Glu Ser Leu Val Phe Ala Gln Thr Asp Lys Pro Ile Tyr Lys Pro Gly 
     130                135                140
Gln Thr Val Arg Phe Arg Val Val Ser Leu Asp Glu Ser Phe His Pro 
 145                150                155                160
Leu Asn Glu Leu Ile Pro Leu Leu Tyr Ile Gln Asp Pro Lys Asn Asn 
                 165                170                175
Arg Ile Ala Gln Trp Gln Asn Phe Asn Leu Glu Gly Gly Leu Lys Gln 
             180                185                190
Leu Ser Phe Pro Leu Ser Ser Glu Pro Thr Gln Gly Ser Tyr Lys Val 
         195                200                205
Val Ile Arg Thr Glu Ser Gly Arg Thr Val Glu His Pro Phe Ser Val 
     210                215                220
Glu Glu Phe Val Leu Pro Lys Phe Glu Val Arg Val Thr Val Pro Glu 
 225                230                235                240
Thr Ile Thr Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Ile 
                 245                250                255
Tyr Thr Tyr Gly Lys Pro Val Pro Gly Arg Val Thr Val Asn Ile Cys 
             260                265                270
Arg Lys Tyr Ser Asn Pro Ser Asn Cys Phe Gly Glu Glu Ser Val Ala 
         275                280                285
Phe Cys Glu Lys Leu Ser Gln Gln Leu Asp Gly Arg Gly Cys Phe Ser 
     290                295                300
Gln Leu Val Lys Thr Lys Ser Phe Gln Leu Lys Arg Gln Glu Tyr Glu 
 305                310                315                320
Met Gln Leu Asp Val His Ala Lys Ile Gln Glu Glu Gly Thr Gly Val 
                 325                330                335
Glu Glu Thr Gly Lys Gly Leu Thr Lys Ile Thr Arg Thr Ile Thr Lys 
             340                345                350
Leu Ser Phe Val Asn Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe 
         355                360                365
Val Gly Gln Val Leu Leu Val Asp Gly Arg Gly Thr Pro Ile Pro Tyr 
     370                375                380
Glu Thr Ile Phe Ile Gly Ala Asp Glu Ala Asn Leu Tyr Ile Asn Thr 
 385                390                395                400
Thr Thr Asp Lys His Gly Leu Ala Arg Phe Ser Ile Asn Thr Asp Asp 
                 405                410                415
Ile Met Gly Thr Ser Leu Thr Val Arg Ala Lys Tyr Lys Asp Ser Asn 
             420                425                430
Ala Cys Tyr Gly Phe Arg Trp Leu Thr Glu Glu Asn Val Glu Ala Trp 
         435                440                445
His Thr Ala Tyr Ala Val Phe Ser Pro Ser Arg Ser Phe Leu His Leu 
     450                455                460
Glu Ser Leu Pro Asp Lys Leu Arg Cys Asp Gln Thr Leu Glu Val Gln 
 465                470                475                480
Ala His Tyr Ile Leu Asn Gly Glu Ala Met Gln Glu Leu Lys Glu Leu 
                 485                490                495
Val Phe Tyr Tyr Leu Met Met Ala Lys Gly Gly Ile Val Arg Ala Gly 
             500                505                510
Thr His Val Leu Pro Leu Lys Gln Gly Gln Met Arg Gly His Phe Ser 
         515                520                525
Ile Leu Ile Ser Met Glu Thr Asp Leu Ala Pro Val Ala Arg Leu Val 
     530                535                540
Leu Tyr Ala Ile Leu Pro Asn Gly Glu Val Val Gly Asp Thr Ala Lys 
 545                550                555                560
Tyr Glu Ile Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Val Phe Arg 
                 565                570                575
Pro Asn Ser Gly Leu Pro Ala Thr Arg Ala Leu Leu Ser Val Met Ala 
             580                585                590
Ser Pro Gln Ser Leu Cys Gly Leu Arg Ala Val Asp Gln Ser Val Leu 
         595                600                605
Leu Met Lys Pro Glu Thr Glu Leu Ser Ala Ser Leu Ile Tyr Asp Leu 
     610                615                620
Leu Pro Val Lys Asp Leu Thr Gly Phe Pro Gln Gly Ala Asp Gln Arg 
 625                630                635                640
Glu Glu Asp Thr Asn Gly Cys Val Lys Gln Asn Asp Thr Tyr Ile Asn 
                 645                650                655
Gly Ile Leu Tyr Ser Pro Val Gln Asn Thr Asn Glu Glu Asp Met Tyr 
             660                665                670
Gly Phe Leu Lys Asp Met Gly Leu Lys Val Phe Thr Asn Ser Asn Ile 
         675                680                685
Arg Lys Pro Lys Val Cys Glu Arg Leu Arg Asp Asn Lys Gly Ile Pro 
     690                695                700
Ala Ala Tyr His Leu Val Ser Gln Ser His Met Asp Ala Phe Leu Glu 
 705                710                715                720
Ser Ser Glu Ser Pro Thr Glu Thr Arg Arg Ser Tyr Phe Pro Glu Thr 
                 725                730                735
Trp Ile Trp Asp Leu Val Val Val Asp Ser Ala Gly Val Ala Glu Val 
             740                745                750
Glu Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly Ala Phe 
         755                760                765
Cys Leu Ser Asn Asp Thr Gly Leu Gly Leu Ser Pro Val Val Gln Phe 
     770                775                780
Gln Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr Ser Val 
 785                790                795                800
Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn Tyr Leu 
                 805                810                815
Pro Thr Cys Ile Arg Val Ala Val Gln Leu Glu Ala Ser Pro Asp Phe 
             820                825                830
Leu Ala Ala Pro Glu Glu Lys Glu Gln Arg Ser His Cys Ile Cys Met 
         835                840                845
Asn Gln Arg His Thr Ala Ser Trp Ala Val Ile Pro Lys Ser Leu Gly 
     850                855                860
Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Asn Ser Lys Glu Leu 
 865                870                875                880
Cys Gly Asn Glu Val Pro Val Val Pro Glu Gln Gly Lys Lys Asp Thr 
                 885                890                895
Ile Ile Lys Ser Leu Leu Val Glu Pro Glu Gly Leu Glu Asn Glu Val 
             900                905                910
Thr Phe Asn Ser Leu Leu Cys Pro Met Gly Ala Glu Val Ser Glu Leu 
         915                920                925
Ile Ala Leu Lys Leu Pro Ser Asp Val Val Glu Glu Ser Ala Arg Ala 
     930                935                940
Ser Val Thr Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln Asn Thr 
 945                950                955                960
Gln Asp Leu Leu Lys Met Pro Tyr Gly Cys Gly Glu Gln Asn Met Val 
                 965                970                975
Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu Thr Gln 
             980                985                990
Gln Leu Thr Gln Glu Ile Lys Thr Lys Ala Ile Ala Tyr Leu Asn Thr 
         995                1000                1005
Gly Tyr Gln Arg Gln Leu Asn Tyr Lys His Arg Asp Gly Ser Tyr Ser 
     1010                1015                1020
Ala Phe Gly Asp Lys Pro Gly Arg Asn His Ala Asn Thr Trp Leu Thr 
 1025                1030                1035                1040
Ala Phe Val Leu Lys Ser Phe Ala Gln Ala Arg Lys Tyr Ile Phe Ile 
                 1045                1050                1055
Asp Glu Val His Ile Thr Gln Ala Leu Leu Trp Leu Ser Gln Gln Gln 
             1060                1065                1070
Lys Asp Asn Gly Cys Phe Arg Ser Ser Gly Ser Leu Leu Asn Asn Ala 
         1075                1080                1085
Met Lys Gly Gly Val Glu Asp Glu Val Thr Leu Ser Ala Tyr Ile Thr 
     1090                1095                1100
Ile Ala Leu Leu Glu Met Ser Leu Pro Val Thr His Pro Val Val Arg 
 1105                1110                1115                1120
Asn Ala Leu Phe Cys Leu Asp Thr Ala Trp Lys Ser Ala Arg Gly Gly 
                 1125                1130                1135
Ala Gly Gly Ser His Val Tyr Thr Lys Ala Leu Leu Ala Tyr Ala Phe 
             1140                1145                1150
Ala Leu Ala Gly Asn Gln Asp Thr Lys Lys Glu Ile Leu Lys Ser Leu 
         1155                1160                1165
Asp Glu Glu Ala Val Lys Glu Glu Asp Ser Val His Trp Thr Arg Pro 
     1170                1175                1180
Gln Lys Pro Ser Val Ser Val Gly Leu Trp Tyr Gln Pro Gln Ala Thr 
 1185                1190                1195                1200
Ser Ala Glu Val Glu Met Thr Ala Tyr Val Leu Leu Ala Tyr Leu Thr 
                 1205                1210                1215
Thr Glu Pro Ala Pro Thr Gln Glu Asp Leu Thr Ala Ala Met Leu Ile 
             1220                1225                1230
Val Lys Trp Leu Thr Lys Gln Gln Asn Ser His Gly Gly Phe Ser Ser 
         1235                1240                1245
Thr Gln Asp Thr Val Val Ala Leu His Ala Leu Ser Lys Tyr Gly Ser 
     1250                1255                1260
Ala Thr Phe Thr Arg Ala Lys Lys Ala Ala Gln Val Thr Ile Arg Ser 
 1265                1270                1275                1280
Ser Gly Thr Phe Ser Thr Lys Phe Gln Val Asn Asn Asn Asn Gln Leu 
                 1285                1290                1295
Leu Leu Gln Arg Val Thr Leu Pro Thr Val Pro Gly Asp Tyr Thr Val 
             1300                1305                1310
Lys Val Thr Gly Glu Gly Cys Val Tyr Leu Gln Thr Ser Leu Lys Tyr 
         1315                1320                1325
Ser Val Leu Pro Arg Glu Glu Glu Phe Pro Phe Ala Val Val Val Gln 
     1330                1335                1340
Thr Leu Pro Gly Thr Cys Glu Asp Pro Lys Ala His Thr Ser Phe Gln 
 1345                1350                1355                1360
Ile Ser Leu Asn Ile Ser Tyr Thr Gly Ser Arg Ser Glu Ser Asn Met 
                 1365                1370                1375
Ala Ile Ala Asp Val Lys Met Val Ser Gly Phe Ile Pro Leu Lys Pro 
             1380                1385                1390
Thr Val Lys Met Leu Glu Arg Ser Val His Val Ser Arg Thr Glu Val 
         1395                1400                1405
Ser Asn Asn His Val Leu Ile Tyr Leu Asp Lys Val Ser Asn Gln Thr 
     1410                1415                1420
Val Asn Leu Ser Phe Thr Val Gln Gln Asp Ile Pro Ile Arg Asp Leu 
 1425                1430                1435                1440
Lys Pro Ala Val Val Lys Val Tyr Asp Tyr Tyr Glu Lys Asp Glu Phe 
                 1445                1450                1455
Ala Val Ala Lys Tyr Ser Ala Pro Cys Ser Thr Asp Tyr Gly Asn Ala 
             1460                1465                1470



<210> 3448
<211> 1474
<212> PRT
<213> Homo sapiens
<308> MAHU
<400> 3448

Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
  1               5                  10                  15
Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
             20                  25                  30
Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys 
         35                  40                  45
Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu 
     50                  55                  60
Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu 
 65                  70                  75                  80
Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                 85                  90                  95
Asn Glu Glu Val Met Phe Leu Thr Val Gln Val Lys Gly Pro Thr Gln 
             100                105                110
Glu Phe Lys Lys Arg Thr Thr Val Met Val Lys Asn Glu Asp Ser Leu 
         115                120                125
Val Phe Val Gln Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val 
     130                135                140
Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
 145                150                155                160
Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala 
                 165                170                175
Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe Ser Phe 
             180                185                190
Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys Val Val Val Gln 
         195                200                205
Lys Lys Ser Gly Gly Arg Thr Glu His Pro Phe Thr Val Glu Glu Phe 
     210                215                220
Val Leu Pro Lys Phe Glu Val Gln Val Thr Val Pro Lys Ile Ile Thr 
 225                230                235                240
Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Leu Tyr Thr Tyr 
                 245                250                255
Gly Lys Pro Val Pro Gly His Val Thr Val Ser Ile Cys Arg Lys Tyr 
             260                265                270
Ser Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu 
         275                280                285
Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val 
     290                295                300
Lys Thr Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met Lys Leu 
 305                310                315                320
His Thr Glu Ala Gln Ile Gln Glu Glu Gly Thr Val Val Glu Leu Thr 
                 325                330                335
Gly Arg Gln Ser Ser Glu Ile Thr Arg Thr Ile Thr Lys Leu Ser Phe 
             340                345                350
Val Lys Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe Phe Gly Gln 
         355                360                365
Val Arg Leu Val Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile 
     370                375                380
Phe Ile Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp 
 385                390                395                400
Glu His Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly 
                 405                410                415
Thr Ser Leu Thr Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys Tyr 
             420                425                430
Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His His Thr Ala 
         435                440                445
Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val His Leu Glu Pro Met 
     450                455                460
Ser His Glu Leu Pro Cys Gly His Thr Gln Thr Val Gln Ala His Tyr 
 465                470                475                480
Ile Leu Asn Gly Gly Thr Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr 
                 485                490                495
Tyr Leu Ile Met Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly 
             500                505                510
Leu Leu Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile 
         515                520                525
Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala 
     530                535                540
Val Leu Pro Thr Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp Val 
 545                550                555                560
Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ser Gln 
                 565                570                575
Ser Leu Pro Ala Ser His Ala His Leu Arg Val Thr Ala Ala Pro Gln 
             580                585                590
Ser Val Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys 
         595                600                605
Pro Asp Ala Glu Leu Ser Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu 
     610                615                620
Lys Asp Leu Thr Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asp Glu 
 625                630                635                640
Asp Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Thr Tyr Thr 
                 645                650                655
Pro Val Ser Ser Thr Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp 
             660                665                670
Met Gly Leu Lys Ala Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Met 
         675                680                685
Cys Pro Gln Leu Gln Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg 
     690                695                700
Val Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His Ala Arg Leu 
 705                710                715                720
Val His Val Glu Glu Pro His Thr Glu Thr Val Arg Lys Tyr Phe Pro 
                 725                730                735
Glu Thr Trp Ile Trp Asp Leu Val Val Val Asn Ser Ala Gly Val Ala 
             740                745                750
Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly 
         755                760                765
Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala 
     770                775                780
Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr 
 785                790                795                800
Ser Val Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn 
                 805                810                815
Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln Leu Glu Ala Ser Pro 
             820                825                830
Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys Ile 
         835                840                845
Cys Ala Asn Gly Arg Gln Thr Val Ser Trp Ala Val Thr Pro Lys Ser 
     850                855                860
Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu Ser Gln 
 865                870                875                880
Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg Lys 
                 885                890                895
Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys 
             900                905                910
Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val Ser 
         915                920                925
Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser Ala 
     930                935                940
Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln 
 945                950                955                960
Asn Thr Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln Asn 
                 965                970                975
Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu 
             980                985                990
Thr Gln Gln Leu Thr Pro Glu Val Lys Ser Lys Ala Ile Gly Tyr Leu 
         995                1000                1005
Asn Thr Gly Tyr Gln Arg Gln Leu Asn Tyr Lys His Tyr Asp Gly Ser 
     1010                1015                1020
Tyr Ser Thr Phe Gly Glu Arg Tyr Gly Arg Asn Gln Gly Asn Thr Trp 
 1025                1030                1035                1040
Leu Thr Ala Phe Val Leu Lys Thr Phe Ala Gln Ala Arg Ala Tyr Ile 
                 1045                1050                1055
Phe Ile Asp Glu Ala His Ile Thr Gln Ala Leu Ile Trp Leu Ser Gln 
             1060                1065                1070
Arg Gln Lys Asp Asn Gly Cys Phe Arg Ser Ser Gly Ser Leu Leu Asn 
         1075                1080                1085
Asn Ala Ile Lys Gly Gly Val Glu Asp Glu Val Thr Leu Ser Ala Tyr 
     1090                1095                1100
Ile Thr Ile Ala Leu Leu Glu Ile Pro Leu Thr Val Thr His Pro Val 
 1105                1110                1115                1120
Val Arg Asn Ala Leu Phe Cys Leu Glu Ser Ala Trp Lys Thr Ala Gln 
                 1125                1130                1135
Glu Gly Asp His Gly Ser His Val Tyr Thr Lys Ala Leu Leu Ala Tyr 
             1140                1145                1150
Ala Phe Ala Leu Ala Gly Asn Gln Asp Lys Arg Lys Glu Val Leu Lys 
         1155                1160                1165
Ser Leu Asn Glu Glu Ala Val Lys Lys Asp Asn Ser Val His Trp Glu 
     1170                1175                1180
Arg Pro Gln Lys Pro Lys Ala Pro Val Gly His Phe Tyr Glu Pro Gln 
 1185                1190                1195                1200
Ala Pro Ser Ala Glu Val Glu Met Thr Ser Tyr Val Leu Leu Ala Tyr 
                 1205                1210                1215
Leu Thr Ala Gln Pro Ala Pro Thr Ser Glu Asp Leu Thr Ser Ala Thr 
             1220                1225                1230
Asn Ile Val Lys Trp Ile Thr Lys Gln Gln Asn Ala Gln Gly Gly Phe 
         1235                1240                1245
Ser Ser Thr Gln Asp Thr Val Val Ala Leu His Ala Leu Ser Lys Tyr 
     1250                1255                1260
Gly Ala Ala Thr Phe Thr Arg Thr Gly Lys Ala Ala Gln Val Thr Ile 
 1265                1270                1275                1280
Gln Ser Ser Gly Thr Phe Ser Ser Lys Phe Gln Val Asp Asn Asn Asn 
                 1285                1290                1295
Arg Leu Leu Leu Gln Gln Val Ser Leu Pro Glu Leu Pro Gly Glu Tyr 
             1300                1305                1310
Ser Met Lys Val Thr Gly Glu Gly Cys Val Tyr Leu Gln Thr Ser Leu 
         1315                1320                1325
Lys Tyr Asn Ile Leu Pro Glu Lys Glu Glu Phe Pro Phe Ala Leu Gly 
     1330                1335                1340
Val Gln Thr Leu Pro Gln Thr Cys Asp Glu Pro Lys Ala His Thr Ser 
 1345                1350                1355                1360
Phe Gln Ile Ser Leu Ser Val Ser Tyr Thr Gly Ser Arg Ser Ala Ser 
                 1365                1370                1375
Asn Met Ala Ile Val Asp Val Lys Met Val Ser Gly Phe Ile Pro Leu 
             1380                1385                1390
Lys Pro Thr Val Lys Met Leu Glu Arg Ser Asn His Val Ser Arg Thr 
         1395                1400                1405
Glu Val Ser Ser Asn His Val Leu Ile Tyr Leu Asp Lys Val Ser Asn 
     1410                1415                1420
Gln Thr Leu Ser Leu Phe Phe Thr Val Leu Gln Asp Val Pro Val Arg 
 1425                1430                1435                1440
Asp Leu Lys Pro Ala Ile Val Lys Val Tyr Asp Tyr Tyr Glu Thr Asp 
                 1445                1450                1455
Glu Phe Ala Ile Ala Glu Tyr Asn Ala Pro Cys Ser Lys Asp Leu Gly 
             1460                1465                1470
Asn Ala 
         1475



<210> 3449
<211> 256
<212> DNA
<213> Rattus norvegicus
<308> M23643
<400> 3449

ctgcccttg  ctcctagac  ccaggatgc  gggaccttg  ttgctgctg  ctctggctt  60
gatcttcac  ctaactggt  tccctgaat  ctgcgcctt  ccggaggca  cccaggagg  120
aggtgcagt  actcctgac  ttcctggcc  ggagaatgt  caggtccgg  cagaacgtc  180
attcttgtg  aaagacctc  agcgggtga  aggggacct  ggtgctgcc  taggtaagc  240
ccaggggag  ggagcc  256



<210> 3450
<211> 255
<212> PRT
<213> Rattus norvegicus
<308> RHRTT
<400> 3450

Met Pro Gly Pro Trp Leu Leu Leu Ala Leu Ala Leu Ile Phe Thr Leu 
  1               5                  10                  15
Thr Gly Ile Pro Glu Ser Cys Ala Leu Pro Glu Ala Ala Gln Glu Glu 
             20                  25                  30
Gly Ala Val Thr Pro Asp Leu Pro Gly Leu Glu Asn Val Gln Val Arg 
         35                  40                  45
Pro Glu Arg Arg Phe Leu Trp Lys Asp Leu Gln Arg Val Arg Gly Asp 
     50                  55                  60
Leu Gly Ala Ala Leu Asp Ser Trp Ile Thr Lys Arg Gln His Pro Gly 
 65                  70                  75                  80
Lys Arg Glu Glu Glu Glu Lys Asp Ile Glu Ala Glu Glu Arg Gly Asp 
                 85                  90                  95
Leu Gly Glu Gly Gly Ala Trp Arg Leu His Lys Arg Gln His Pro Gly 
             100                105                110
Arg Arg Ala Asn Gln Asp Lys Tyr Ser Trp Ala Asp Glu Glu Asp Ser 
         115                120                125
Asp Trp Met Pro Arg Ser Trp Leu Pro Asp Phe Phe Leu Asp Ser Trp 
     130                135                140
Phe Ser Asp Val Pro Gln Val Lys Arg Gln His Pro Gly Arg Arg Ser 
 145                150                155                160
Phe Pro Trp Met Glu Ser Asp Val Thr Lys Arg Gln His Pro Gly Arg 
                 165                170                175
Arg Phe Ile Asp Pro Glu Leu Gln Arg Ser Trp Glu Glu Lys Glu Gly 
             180                185                190
Glu Gly Val Leu Met Pro Glu Lys Arg Gln His Pro Gly Lys Arg Ala 
         195                200                205
Leu Gly His Pro Cys Gly Pro Gln Gly Thr Cys Gly Gln Thr Gly Leu 
     210                215                220
Leu Gln Leu Leu Gly Asp Leu Ser Arg Gly Gln Glu Thr Leu Val Lys 
 225                230                235                240
Gln Ser Pro Gln Val Glu Pro Trp Asp Lys Glu Pro Leu Glu Glu 
                 245                250                255



<210> 3451
<211> 1359
<212> DNA
<213> Homo sapiens
<308> M63582
<400> 3451

tttccttcc  cagcgtccc  gatctttca  tctgactgg  tctccaaac  tcagcatcc  60
ggcaaaaga  aggaggagg  ggaagaggg  gttgaagaa  aggaagagg  agaaggggg  120
gctgtggga  cccacaaac  gcagcaccc  ggccgacga  aagatgagg  ttcatggtc  180
gtcgatgta  cccagcaca  gcggcagca  cctggccgg  gctccccct  gcttgcata  240
gctgtcccg  agcggcagc  cccaggcag  aggctggca  atcccaagg  tcaaaggag  300
tgggaagaa  aggaggagg  ggaagagag  gaggaagac  tgatgcctg  aaaacgcca  360
catccgggc  agagggccc  gggaggccc  tgtgggccc  agggagcct  tggtcaagc  420
ggcctcctg  tggggctcc  ggatgacct  agtaggagc  agggagctg  ggaaaagcg  480
cagcaccct  gtcggcggg  agcctgggt  agggagccc  tggaggagt  aacccagtt  540
tccctgaag  cgagtttgt  gtctaagga  gtcttgagc  ctgtgtgcc  caccattca  600
gacctctgt  ttctctagt  agatccctg  ccataagcc  gagcccctc  ctcccagcc  660
catattcac  cacatccca  cccctggcc  tgccctctt  ctttaggca  gtgagaaaa  720
cagcctagc  gtttaaacc  cactttcct  cacttagca  cataggcaa  ggggcagat  780
ccagagccc  tctcacccc  cccaccaca  gcctgctcc  tccttagcc  tggctaaga  840
ggtccttct  tgtcttgca  agactcccc  agtggacag  gagcccctg  gagggcagc  900
agtgagggt  gggtgggac  gaagcgttg  gtgcaaatc  agcttccat  ccctcccca  960
cctggcagg  ttctccatg  gtaaacttc  cccccagga  ccaggatct  ctcctttct  1020
ggcatccct  tgtgggtgg  cagagccct  acccacagc  gtgttactg  ttggagaag  1080
atatgtagg  gcataccct  tggtgttgt  ctgtgtctg  ctgtgggat  aatgtgtgt  1140
ggaatattg  aacatcgcc  aggaattgt  gtttgtata  aaccctcta  gcccctatc  1200
cttgtcgat  acagtcatc  taatgataa  aaaacctgc  tccagataa  cacggagct  1260
tgtggttgc  gttctgtcg  agctggcat  ggattcttc  ttcgcattg  gagggatat  1320
taaaagggg  tgggactag  gttctcagc  ctgctgcag  1359



<210> 3452
<211> 242
<212> PRT
<213> Homo sapiens
<308> P20396
<400> 3452

Met Pro Gly Pro Trp Leu Leu Leu Ala Leu Ala Leu Thr Leu Asn Leu 
  1               5                  10                  15
Thr Gly Val Pro Gly Gly Arg Ala Gln Pro Glu Ala Ala Gln Gln Glu 
             20                  25                  30
Ala Val Thr Ala Ala Glu His Pro Gly Leu Asp Asp Phe Leu Arg Gln 
         35                  40                  45
Val Glu Arg Leu Leu Phe Leu Arg Glu Asn Ile Gln Arg Leu Gln Gly 
     50                  55                  60
Asp Gln Gly Glu His Ser Ala Ser Gln Ile Phe Gln Ser Asp Trp Leu 
 65                  70                  75                  80
Ser Lys Arg Gln His Pro Gly Lys Arg Glu Glu Glu Glu Glu Glu Gly 
                 85                  90                  95
Val Glu Glu Glu Glu Glu Glu Glu Gly Gly Ala Val Gly Pro His Lys 
             100                105                110
Arg Gln His Pro Gly Arg Arg Glu Asp Glu Ala Ser Trp Ser Val Asp 
         115                120                125
Val Thr Gln His Lys Arg Gln His Pro Gly Arg Arg Ser Pro Trp Leu 
     130                135                140
Ala Tyr Ala Val Pro Lys Arg Gln His Pro Gly Arg Arg Leu Ala Asp 
 145                150                155                160
Pro Lys Ala Gln Arg Ser Trp Glu Glu Glu Glu Glu Glu Glu Glu Arg 
                 165                170                175
Glu Glu Asp Leu Met Pro Glu Lys Arg Gln His Pro Gly Lys Arg Ala 
             180                185                190
Leu Gly Gly Pro Cys Gly Pro Gln Gly Ala Tyr Gly Gln Ala Gly Leu 
         195                200                205
Leu Leu Gly Leu Leu Asp Asp Leu Ser Arg Ser Gln Gly Ala Glu Glu 
     210                215                220
Lys Arg Gln His Pro Gly Arg Arg Ala Ala Trp Val Arg Glu Pro Leu 
 225                230                235                240
Glu Glu 
                 245



<210> 3453
<211> 1482
<212> DNA
<213> Rattus norvegicus
<308> M24104
<400> 3453

gaattcggg  tccgtctac  tcagccgca  cgtctccct  cctgtctca  tgcattctc  60
agagagggg  cggacctcc  cttcctctt  cagaaaaat  tctgctcca  ctcagccac  120
tgctgaagg  acagaaggg  ctgccccag  tgggggtcc  cctggtcct  ctcccaata  180
gaccagtaa  agacgatta  agcaaaccc  ggcacaagt  gaggaggtg  tggacatca  240
tcgcgtgaa  gtggacaag  tcttggaga  ggaccagaa  ttgtcagag  tggatgacc  300
agctgacgc  ttgcaggca  gagcgtcag  gtttgagag  agtgctgcc  agctaaaaa  360
gaagtattg  tggaaaaac  gcaagatga  gatcatgct  ggagctatc  gtgccatca  420
cgtggtagt  attgtaatc  acattttta  ttgagaatg  gccatccct  ccctgttct  480
cattgccat  caagctcat  tttcccctc  gtttgctct  tcaacaaag  cctccatct  540
ccgttctcc  tcctggccc  ggcttctct  tgatccgac  ttccctttt  gtgcattca  600
tcgcactct  cctcaaaac  agaaatgct  ctcgtggca  agtcctgaa  gtcactgcc  660
gaagagaac  cccagcacc  cctctttac  catttatca  gtgccctgg  gcttaaaag  720
gttgtggcc  atggcagag  tgaagtgtc  gagaagtta  catggctga  gggaagaga  780
aggcatttg  gtccaagaa  ggctggcct  tggcaggag  gaagcaaga  tagttggga  840
gtagtagct  gctgccagt  tatatgtat  tgtatatgt  tatgtatat  tatatgtat  900
tgtatatgt  tatattagt  gggaactat  acctgctgt  ctcatttgg  actttcctc  960
cataccagg  ctgtcttgg  tcccagagg  ctgtttaaa  accaacttc  aatcccttt  1020
agaaaaaca  caaacttgc  ttttgtagc  actgttatc  gtcagtaca  gattttctg  1080
gtctttggg  gaactttac  acttttcgc  ttgtctcta  agccccagg  gagaagtac  1140
ttctgattt  aaaaacagc  ggacactct  accttcttc  agaaggcgt  ccacatgct  1200
ctgactaga  ggagctacc  cctcttcat  tcatctgaa  catttgatg  tgttcatga  1260
ggcaccaaa  aatttcagg  aatgagggg  tttgaggat  acaggctct  aggaacacg  1320
tccatgcca  cccactctc  aatgaaagc  ctgtacctc  cttgttgat  aagagaaat  1380
agagttata  ggtgagact  ccagggtcc  acagaacac  tccccctgc  ctacccact  1440
actgtgtgt  agacaagga  gaggcagga  ggccccgaa  tc  1482



<210> 3454
<211> 115
<212> PRT
<213> Rattus norvegicus
<308> Q64357
<400> 3454

Ser Ala Thr Ala Ala Thr Val Pro Pro Ala Ala Pro Ala Gly Glu Gly 
  1               5                  10                  15
Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln 
             20                  25                  30
Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
         35                  40                  45
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
     50                  55                  60
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
 65                  70                  75                  80
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile 
                 85                  90                  95
Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr 
             100                105                110
Phe Ser Thr 
         115



<210> 3455
<211> 6885
<212> DNA
<213> Homo sapiens
<308> AF135372
<400> 3455

tcaagacca  cctggctaa  acggtgaaa  cctgtctct  ctaaaaata  aaaaaatta  60
ccgggcggg  tggtgggcg  ctgtagtcc  agctactcg  gaggctgag  gaggagaat  120
gcgtgaacc  gggaggcgg  gtttgcagt  agcagagat  gcgccattg  actccagcc  180
gggtgacag  cagagactc  gtctcaaaa  agaaaaaaa  agaaaaaaa  aaaaagaaa  240
tgtggtctc  gttgcctac  tcaccatca  cttgagtcc  acatccttt  aatgagtct  300
gggggtgtg  cctagaaaa  cattggcca  ttcccgaag  cagtacatg  agaagccaa  360
tctgagtta  gcaaataca  tatttttct  ttgttcaac  tacctctat  tgggtctcc  420
ttctacctg  ctgcaagaa  acattctct  agtcacttc  aggtgaact  cgtcatccc  480
ctccttctc  cacctccac  attgatcta  atttgggga  ttcctctga  ccacagcct  540
ggtggggtg  ggtgggaag  ggctgctgg  tgagagtcc  ctttctgag  tgaatcctc  600
tgggccctt  atctccgtg  gtcacacat  ccctcattt  tactctgct  ctgccgtcc  660
cacgatcca  tagcaatag  acgacccct  gccttgacc  tgtatctgg  gctctgtcc  720
ttccacatc  cccccaaac  agcatcaaa  gtcttgtct  gctctgcac  aggctcccc  780
cagttagtg  aggggtgtc  aactggggg  ggaagggct  cctgtgcct  cctcttcca  840
tcctccatg  cttatttat  ccctgacag  catgaaggg  tttgaactt  aaaggctgg  900
aatttggca  cttttgttc  ctgactaag  aagaggaaa  catttcaag  ccaaaaagc  960
gggagccag  atctcacag  atggatctg  gaccccccg  ggaagctgc  cttttcttt  1020
tcatcacat  agcgtgagc  cgggactgt  agtgcacaa  gaccaggga  gcggctgct  1080
ctctgaggg  gaggaagcc  agagtatct  ctcttagat  gggctgagt  cccacaccc  1140
gcacacaca  tccctgctc  ctcacctcc  acagacagc  gggaaatga  acctctggt  1200
acagagcca  tctccgggc  tctgtgggg  gcgggtggg  cactgcagt  ggggaggat  1260
tcacacccg  aggccctgg  aagccaggg  gggggaggg  ggaagctgg  tcctgtttg  1320
cttagagat  aaggccatc  gcctccctg  accttccag  gatgtagta  gcaccccca  1380
cccagggcc  aagggcctc  cctaaaatg  ctcctgcac  cttgaggct  gctttgacc  1440
cctgcactc  accaagagc  acagctccc  tgggtccca  cttctctga  aagctgggt  1500
ggagtgtat  cagctgctg  gtgtgctta  agggcctaa  ggagaccag  cagggataa  1560
ctcctatgt  atccacatc  agccattta  caaatatgg  tttagtacc  acatatgca  1620
tgtatttgg  gtccagaga  aggagggca  cggtccaag  tcacacctg  gaggcgaat  1680
cgcatgtaa  gcagcacct  gtaacctgt  cccactgtg  ctactacta  agaaaaata  1740
atgagagaa  aagaaaaaa  gcttttttt  tttttggcc  aggccctgt  cctgggacc  1800
aagcctgag  cctttcctg  agtcgggtc  ctgacctaa  cctggggca  agctaggtc  1860
tggccagtc  gcagccacc  cgtgaagca  cccctgccc  catcacccc  ggcagcctt  1920
tgccctcct  ctcggggtc  tcagctcac  ccacctcag  cgggcctgc  ccagcggtt  1980
agtacccct  gtctgaacc  taatcgtga  gcggggcag  cccctcccc  caccctgta  2040
acactcccc  gtcctccgc  ccctggact  gtttgggcg  gaagagcct  cctcatctt  2100
tcttcctac  ctcctaccc  gtggccagg  accccaggc  tcctctgag  catccacca  2160
cggtgatgg  ttgggacca  tctccccca  tcctctcca  cctagcagt  aggtccccg  2220
tctcgatac  gccccagca  ctgcactgg  cctctctga  ttcccaact  cagcccatt  2280
caagtgctg  aggcgggtc  ctaggtgct  ggacctggg  gcggggcaa  accttgggc  2340
gtgtggggt  caggctggg  ttactgggt  cacgattga  ggagtggtc  gggggttag  2400
tgtagggcc  ggctgcgtt  tgctctaag  ggcaggcgg  aggcggttt  ggggggctg  2460
ggtcagaca  ggtggggtg  cggtgggtt  ggggaagcc  cagcagccc  ccttggggt  2520
ccgcgagtg  cgagggagc  gccggggca  ggtggcgcg  ggcccgtgg  cctgcccgg  2580
acgaccccc  ccccgcagc  ccccgcagc  ccccgcccc  gcggccccg  tcgcgacgc  2640
tctcccgcg  cgccccgcc  ccgcccgca  tgcccggat  cgggtgacg  gcggccgcc  2700
tctttccgt  ccgggcagc  agcgccagt  ggagccagc  cgagcgccg  cgccatcac  2760
gccgctgcc  agtcctcca  ccgctgccc  cgccatgtg  gtcggccgc  cgccaccct  2820
accgcgctt  cctgcgccg  ccgccgccc  tggcaaccg  ccgtcggga  tgcccgggg  2880
ctcttctgc  ttccccgcg  cccggggcc  ggcccaagc  ggtgactgc  cgcgggcgg  2940
cgaggagcc  cgcgtcccg  gctggccgg  tcgggcgat  gccgcggga  ggagcggac  3000
cagtgtcct  ctgcccctc  ccgcccctg  caccgcggc  gcctgtctt  tcgggtcga  3060
ccggatcgc  tctgtgagg  cgccctcag  tgacaggcg  ggaaactga  gccgggggg  3120
cctcgctca  ggtcacgca  ctcatcggc  gcagggctg  accgagacc  gggcttaca  3180
cgggtggcc  tcctcccga  aaggaggac  ggagggacn  ggatggaca  gtggatggg  3240
ggagccctg  ctgcggggc  gggaggctg  aagccctgg  tcttaatcc  tccctgctc  3300
tcaggtctg  taccgctgc  acggccccc  ctgctgccc  ggctgggga  ggtggtccc  3360
ctgcacccc  tccaaacct  accagtaac  ggagactgc  gcagaccca  gcccaggtg  3420
atgaggtga  tgtgggggg  gtcaaaacc  gtaggaggg  ccctggggg  tggggatag  3480
tgtaggggc  cattttggt  tgggagtga  gacagttca  gcctttggg  ttgcggaca  3540
agataccat  ccccatccc  gtctccctg  cagcacgca  ttggaaggg  gctgggggt  3600
ttaatcagc  ttgctagcc  ggggtgtgc  agcctgggc  ggtgtgctc  ggtgatgga  3660
agagcgcct  aggttccat  gagggaggg  gttgctatg  catntgaga  gtcaccagc  3720
tgcccctga  gtgtgctcc  tgcatgtcc  caggtgtgc  aggcatgtt  tgtgtgtcc  3780
tggcatgtt  acctggcag  atcagggtg  atgttccat  tgtggcacg  tgggcacat  3840
tttgaggat  gccctcact  aggtgggcc  tggcacacc  ccctgcctc  tgggccctt  3900
tcccaggtg  tggacatca  gagggtgaa  gtggacaag  tcctggagc  agaccagaa  3960
ctgtcggag  tggacgacc  tgcagatgc  ctccaggcg  gggcctccc  gtttgaaac  4020
agcgcagcc  agctcaagc  caaatactg  tggaaaaac  tcaaggtaa  ggtggggac  4080
ggaaggagg  caggtgggt  aatggggta  catagtttg  cttactgat  ctcgcctct  4140
acccccaga  gatgatcat  ttgggagtg  tttgcgcca  catcctcat  atcatcata  4200
gtgagtagg  tgagaatgg  cggggccct  tccctggag  ggtttcccc  gtggattct  4260
ggttttgaa  gtcattaat  tagttttta  tcttcagcc  aaaacacat  tagctgcta  4320
tggcaattc  gattcatct  gagccaaaa  ctttgatgt  atttagcct  cattttgcc  4380
agttcttgg  agtcttgtt  acatttgga  ataggaaag  tggtgtatc  attgaggac  4440
ctttaggcc  aagagccca  tctgagaac  ctggaattg  ggagtggga  aaaggaaag  4500
accaggggc  tgagacatg  ccaggaagc  aaccacccc  ttatttgag  gcttgcggt  4560
tcagaggct  agaggatta  ggtctgtgg  ttcaaggcc  taccatgga  cggaaggga  4620
ctcagaacc  acctgtcta  ccccttgct  tgtagatgg  aaaactgag  ccaagagag  4680
gtgtcagcc  gctggggag  ggggaggat  ggagcaggg  caggcctga  acactgctt  4740
cttgttctc  ctctttctc  cccctctcc  tcttcctca  cttcttccc  tctctccac  4800
gtttacttc  gctcttaaa  ccccgagga  tctgccctg  ctagagaag  gcctctccc  4860
caaccctca  ccgttcctc  acctctcag  catatcttt  agccccccc  cccctggat  4920
cgtgtgtgt  tgtgtccgt  tgtgtgtcc  cctgtaaat  gccagctgt  atttataca  4980
atataatat  atatatatt  ggtctgttt  tagttttat  actagatga  ttttccggt  5040
gtccttaac  ccccttcct  aggttccct  cacccctct  tcttgcctt  cttcccttt  5100
cctttcttc  tgactagcc  caagtccct  catttgcat  tgctatgca  tagtccctc  5160
cctttcctt  ttcttccct  agatttagc  gatccttcc  cccaccctg  ccttccttt  5220
ctctttcct  ctcactctc  ccgtcatgc  ccctctgcc  cgccctcaa  aaaaaaaaa  5280
aaaaaaaaa  aaaaaaaaa  caccagcac  tgtccaggc  tccttaggt  catcttctt  5340
gtatccatt  ggaggctct  agactggcc  cacttggtc  taaaaatcc  aaggtcttt  5400
ggagcgtcc  gcatgttaa  tagcgtatc  ttacatact  ctatccctt  ccatttctt  5460
ttgttccat  actcttctc  caacctgtg  ttctttttt  actgaggag  tagtcccca  5520
tagttcttg  atcacattt  catttgcac  acattactc  caggtggtg  ggagcctgg  5580
cttttgggg  accaggctg  tctggtccc  agcattgcc  cctcctagc  cctctagtc  5640
agtttgcct  ccttaccct  attttccaa  cctcttgta  cctcctctc  ctcccccag  5700
ggtatgtaa  tgtcttgaa  ttcagtatg  tatgatgga  caataattc  gcccttcgg  5760
tttctccct  cattcctgc  ccccagttt  catgtgggg  actcaactg  cattcccat  5820
gggtttccc  cccatctgc  tgatccacc  cctcctccc  ccacaagat  aattgttgg  5880
cacaattga  ctcttgtag  ggggtggct  ccagtgtgt  tgtgggggt  atcactgcc  5940
tggggagga  tggggcagg  cagagaatc  ccccaattc  tgcctgaaa  ctctggcct  6000
acccctgct  ggggttgga  tgaaaaccc  cctccccaa  ttggggggt  ttgccccat  6060
actgcccag  tcctctgac  gccccccct  aatttaggg  gggggtact  gtcactgcc  6120
atgtgtgta  gggacttgc  ggaaaacgg  gatgcttgc  cctctccag  actattgag  6180
ccagagaga  ctgtcctct  attgggtga  ctgattgag  aagggtcta  tgtcttttt  6240
aatggcaca  ttttaaggg  ttgagggta  agtccctta  cctgccacg  gagggggcc  6300
ccaaacttt  ttccccccc  cacttctgg  tttctgtgt  gagggggag  agggatatc  6360
aagctgtgg  gtgaaaggg  aggagagat  ctggaggtg  gggtgctgt  ttctagacc  6420
cccatatta  cccagtgtc  cctgccccc  tcttccccc  ccccatgcc  ccaattctg  6480
ggcgcatcc  gattgtgaa  atgtacaat  aatgtgtaa  gagtaacca  gtgttgtct  6540
agatctttt  tatttttct  ttttttttt  ttggttggg  gagaataag  tcttttctt  6600
accaatggg  ataatattg  atcggaagg  ataccagga  ggttgagaa  atacattgg  6660
aatggactg  actttgcaa  aggccctga  cttgggcag  gcaaagtgt  attctcaaa  6720
tggccacag  ggggcacta  gagttggta  tgggaagtg  catagccag  ccgtgtctc  6780
aagcccggt  cgccctatg  tctagggtt  ccagctttc  tttcccttt  ctggggcat  6840
ttcctgctg  tggactcct  tctactcct  gatttaact  ctaga  6885



<210> 3456
<211> 115
<212> PRT
<213> Homo sapiens
<308> P19065
<400> 3456

Ser Ala Thr Ala Ala Thr Ala Pro Pro Ala Ala Pro Ala Gly Glu Gly 
  1               5                  10                  15
Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln 
             20                  25                  30
Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
         35                  40                  45
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
     50                  55                  60
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
 65                  70                  75                  80
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile 
                 85                  90                  95
Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr 
             100                105                110
Phe Ser Ser 
         115



<210> 3457
<211> 1482
<212> DNA
<213> Rattus norvegicus
<308> M24104
<400> 3457

gaattcggg  tccgtctac  tcagccgca  cgtctccct  cctgtctca  tgcattctc  60
agagagggg  cggacctcc  cttcctctt  cagaaaaat  tctgctcca  ctcagccac  120
tgctgaagg  acagaaggg  ctgccccag  tgggggtcc  cctggtcct  ctcccaata  180
gaccagtaa  agacgatta  agcaaaccc  ggcacaagt  gaggaggtg  tggacatca  240
tcgcgtgaa  gtggacaag  tcttggaga  ggaccagaa  ttgtcagag  tggatgacc  300
agctgacgc  ttgcaggca  gagcgtcag  gtttgagag  agtgctgcc  agctaaaaa  360
gaagtattg  tggaaaaac  gcaagatga  gatcatgct  ggagctatc  gtgccatca  420
cgtggtagt  attgtaatc  acattttta  ttgagaatg  gccatccct  ccctgttct  480
cattgccat  caagctcat  tttcccctc  gtttgctct  tcaacaaag  cctccatct  540
ccgttctcc  tcctggccc  ggcttctct  tgatccgac  ttccctttt  gtgcattca  600
tcgcactct  cctcaaaac  agaaatgct  ctcgtggca  agtcctgaa  gtcactgcc  660
gaagagaac  cccagcacc  cctctttac  catttatca  gtgccctgg  gcttaaaag  720
gttgtggcc  atggcagag  tgaagtgtc  gagaagtta  catggctga  gggaagaga  780
aggcatttg  gtccaagaa  ggctggcct  tggcaggag  gaagcaaga  tagttggga  840
gtagtagct  gctgccagt  tatatgtat  tgtatatgt  tatgtatat  tatatgtat  900
tgtatatgt  tatattagt  gggaactat  acctgctgt  ctcatttgg  actttcctc  960
cataccagg  ctgtcttgg  tcccagagg  ctgtttaaa  accaacttc  aatcccttt  1020
agaaaaaca  caaacttgc  ttttgtagc  actgttatc  gtcagtaca  gattttctg  1080
gtctttggg  gaactttac  acttttcgc  ttgtctcta  agccccagg  gagaagtac  1140
ttctgattt  aaaaacagc  ggacactct  accttcttc  agaaggcgt  ccacatgct  1200
ctgactaga  ggagctacc  cctcttcat  tcatctgaa  catttgatg  tgttcatga  1260
ggcaccaaa  aatttcagg  aatgagggg  tttgaggat  acaggctct  aggaacacg  1320
tccatgcca  cccactctc  aatgaaagc  ctgtacctc  cttgttgat  aagagaaat  1380
agagttata  ggtgagact  ccagggtcc  acagaacac  tccccctgc  ctacccact  1440
actgtgtgt  agacaagga  gaggcagga  ggccccgaa  tc  1482



<210> 3458
<211> 115
<212> PRT
<213> Rattus norvegicus
<308> Q64357
<400> 3458

Ser Ala Thr Ala Ala Thr Val Pro Pro Ala Ala Pro Ala Gly Glu Gly 
  1               5                  10                  15
Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln 
             20                  25                  30
Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
         35                  40                  45
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
     50                  55                  60
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
 65                  70                  75                  80
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile 
                 85                  90                  95
Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr 
             100                105                110
Phe Ser Thr 
         115



<210> 3459
<211> 6885
<212> DNA
<213> Homo sapiens
<308> AF135372
<400> 3459

tcaagacca  cctggctaa  acggtgaaa  cctgtctct  ctaaaaata  aaaaaatta  60
ccgggcggg  tggtgggcg  ctgtagtcc  agctactcg  gaggctgag  gaggagaat  120
gcgtgaacc  gggaggcgg  gtttgcagt  agcagagat  gcgccattg  actccagcc  180
gggtgacag  cagagactc  gtctcaaaa  agaaaaaaa  agaaaaaaa  aaaaagaaa  240
tgtggtctc  gttgcctac  tcaccatca  cttgagtcc  acatccttt  aatgagtct  300
gggggtgtg  cctagaaaa  cattggcca  ttcccgaag  cagtacatg  agaagccaa  360
tctgagtta  gcaaataca  tatttttct  ttgttcaac  tacctctat  tgggtctcc  420
ttctacctg  ctgcaagaa  acattctct  agtcacttc  aggtgaact  cgtcatccc  480
ctccttctc  cacctccac  attgatcta  atttgggga  ttcctctga  ccacagcct  540
ggtggggtg  ggtgggaag  ggctgctgg  tgagagtcc  ctttctgag  tgaatcctc  600
tgggccctt  atctccgtg  gtcacacat  ccctcattt  tactctgct  ctgccgtcc  660
cacgatcca  tagcaatag  acgacccct  gccttgacc  tgtatctgg  gctctgtcc  720
ttccacatc  cccccaaac  agcatcaaa  gtcttgtct  gctctgcac  aggctcccc  780
cagttagtg  aggggtgtc  aactggggg  ggaagggct  cctgtgcct  cctcttcca  840
tcctccatg  cttatttat  ccctgacag  catgaaggg  tttgaactt  aaaggctgg  900
aatttggca  cttttgttc  ctgactaag  aagaggaaa  catttcaag  ccaaaaagc  960
gggagccag  atctcacag  atggatctg  gaccccccg  ggaagctgc  cttttcttt  1020
tcatcacat  agcgtgagc  cgggactgt  agtgcacaa  gaccaggga  gcggctgct  1080
ctctgaggg  gaggaagcc  agagtatct  ctcttagat  gggctgagt  cccacaccc  1140
gcacacaca  tccctgctc  ctcacctcc  acagacagc  gggaaatga  acctctggt  1200
acagagcca  tctccgggc  tctgtgggg  gcgggtggg  cactgcagt  ggggaggat  1260
tcacacccg  aggccctgg  aagccaggg  gggggaggg  ggaagctgg  tcctgtttg  1320
cttagagat  aaggccatc  gcctccctg  accttccag  gatgtagta  gcaccccca  1380
cccagggcc  aagggcctc  cctaaaatg  ctcctgcac  cttgaggct  gctttgacc  1440
cctgcactc  accaagagc  acagctccc  tgggtccca  cttctctga  aagctgggt  1500
ggagtgtat  cagctgctg  gtgtgctta  agggcctaa  ggagaccag  cagggataa  1560
ctcctatgt  atccacatc  agccattta  caaatatgg  tttagtacc  acatatgca  1620
tgtatttgg  gtccagaga  aggagggca  cggtccaag  tcacacctg  gaggcgaat  1680
cgcatgtaa  gcagcacct  gtaacctgt  cccactgtg  ctactacta  agaaaaata  1740
atgagagaa  aagaaaaaa  gcttttttt  tttttggcc  aggccctgt  cctgggacc  1800
aagcctgag  cctttcctg  agtcgggtc  ctgacctaa  cctggggca  agctaggtc  1860
tggccagtc  gcagccacc  cgtgaagca  cccctgccc  catcacccc  ggcagcctt  1920
tgccctcct  ctcggggtc  tcagctcac  ccacctcag  cgggcctgc  ccagcggtt  1980
agtacccct  gtctgaacc  taatcgtga  gcggggcag  cccctcccc  caccctgta  2040
acactcccc  gtcctccgc  ccctggact  gtttgggcg  gaagagcct  cctcatctt  2100
tcttcctac  ctcctaccc  gtggccagg  accccaggc  tcctctgag  catccacca  2160
cggtgatgg  ttgggacca  tctccccca  tcctctcca  cctagcagt  aggtccccg  2220
tctcgatac  gccccagca  ctgcactgg  cctctctga  ttcccaact  cagcccatt  2280
caagtgctg  aggcgggtc  ctaggtgct  ggacctggg  gcggggcaa  accttgggc  2340
gtgtggggt  caggctggg  ttactgggt  cacgattga  ggagtggtc  gggggttag  2400
tgtagggcc  ggctgcgtt  tgctctaag  ggcaggcgg  aggcggttt  ggggggctg  2460
ggtcagaca  ggtggggtg  cggtgggtt  ggggaagcc  cagcagccc  ccttggggt  2520
ccgcgagtg  cgagggagc  gccggggca  ggtggcgcg  ggcccgtgg  cctgcccgg  2580
acgaccccc  ccccgcagc  ccccgcagc  ccccgcccc  gcggccccg  tcgcgacgc  2640
tctcccgcg  cgccccgcc  ccgcccgca  tgcccggat  cgggtgacg  gcggccgcc  2700
tctttccgt  ccgggcagc  agcgccagt  ggagccagc  cgagcgccg  cgccatcac  2760
gccgctgcc  agtcctcca  ccgctgccc  cgccatgtg  gtcggccgc  cgccaccct  2820
accgcgctt  cctgcgccg  ccgccgccc  tggcaaccg  ccgtcggga  tgcccgggg  2880
ctcttctgc  ttccccgcg  cccggggcc  ggcccaagc  ggtgactgc  cgcgggcgg  2940
cgaggagcc  cgcgtcccg  gctggccgg  tcgggcgat  gccgcggga  ggagcggac  3000
cagtgtcct  ctgcccctc  ccgcccctg  caccgcggc  gcctgtctt  tcgggtcga  3060
ccggatcgc  tctgtgagg  cgccctcag  tgacaggcg  ggaaactga  gccgggggg  3120
cctcgctca  ggtcacgca  ctcatcggc  gcagggctg  accgagacc  gggcttaca  3180
cgggtggcc  tcctcccga  aaggaggac  ggagggacn  ggatggaca  gtggatggg  3240
ggagccctg  ctgcggggc  gggaggctg  aagccctgg  tcttaatcc  tccctgctc  3300
tcaggtctg  taccgctgc  acggccccc  ctgctgccc  ggctgggga  ggtggtccc  3360
ctgcacccc  tccaaacct  accagtaac  ggagactgc  gcagaccca  gcccaggtg  3420
atgaggtga  tgtgggggg  gtcaaaacc  gtaggaggg  ccctggggg  tggggatag  3480
tgtaggggc  cattttggt  tgggagtga  gacagttca  gcctttggg  ttgcggaca  3540
agataccat  ccccatccc  gtctccctg  cagcacgca  ttggaaggg  gctgggggt  3600
ttaatcagc  ttgctagcc  ggggtgtgc  agcctgggc  ggtgtgctc  ggtgatgga  3660
agagcgcct  aggttccat  gagggaggg  gttgctatg  catntgaga  gtcaccagc  3720
tgcccctga  gtgtgctcc  tgcatgtcc  caggtgtgc  aggcatgtt  tgtgtgtcc  3780
tggcatgtt  acctggcag  atcagggtg  atgttccat  tgtggcacg  tgggcacat  3840
tttgaggat  gccctcact  aggtgggcc  tggcacacc  ccctgcctc  tgggccctt  3900
tcccaggtg  tggacatca  gagggtgaa  gtggacaag  tcctggagc  agaccagaa  3960
ctgtcggag  tggacgacc  tgcagatgc  ctccaggcg  gggcctccc  gtttgaaac  4020
agcgcagcc  agctcaagc  caaatactg  tggaaaaac  tcaaggtaa  ggtggggac  4080
ggaaggagg  caggtgggt  aatggggta  catagtttg  cttactgat  ctcgcctct  4140
acccccaga  gatgatcat  ttgggagtg  tttgcgcca  catcctcat  atcatcata  4200
gtgagtagg  tgagaatgg  cggggccct  tccctggag  ggtttcccc  gtggattct  4260
ggttttgaa  gtcattaat  tagttttta  tcttcagcc  aaaacacat  tagctgcta  4320
tggcaattc  gattcatct  gagccaaaa  ctttgatgt  atttagcct  cattttgcc  4380
agttcttgg  agtcttgtt  acatttgga  ataggaaag  tggtgtatc  attgaggac  4440
ctttaggcc  aagagccca  tctgagaac  ctggaattg  ggagtggga  aaaggaaag  4500
accaggggc  tgagacatg  ccaggaagc  aaccacccc  ttatttgag  gcttgcggt  4560
tcagaggct  agaggatta  ggtctgtgg  ttcaaggcc  taccatgga  cggaaggga  4620
ctcagaacc  acctgtcta  ccccttgct  tgtagatgg  aaaactgag  ccaagagag  4680
gtgtcagcc  gctggggag  ggggaggat  ggagcaggg  caggcctga  acactgctt  4740
cttgttctc  ctctttctc  cccctctcc  tcttcctca  cttcttccc  tctctccac  4800
gtttacttc  gctcttaaa  ccccgagga  tctgccctg  ctagagaag  gcctctccc  4860
caaccctca  ccgttcctc  acctctcag  catatcttt  agccccccc  cccctggat  4920
cgtgtgtgt  tgtgtccgt  tgtgtgtcc  cctgtaaat  gccagctgt  atttataca  4980
atataatat  atatatatt  ggtctgttt  tagttttat  actagatga  ttttccggt  5040
gtccttaac  ccccttcct  aggttccct  cacccctct  tcttgcctt  cttcccttt  5100
cctttcttc  tgactagcc  caagtccct  catttgcat  tgctatgca  tagtccctc  5160
cctttcctt  ttcttccct  agatttagc  gatccttcc  cccaccctg  ccttccttt  5220
ctctttcct  ctcactctc  ccgtcatgc  ccctctgcc  cgccctcaa  aaaaaaaaa  5280
aaaaaaaaa  aaaaaaaaa  caccagcac  tgtccaggc  tccttaggt  catcttctt  5340
gtatccatt  ggaggctct  agactggcc  cacttggtc  taaaaatcc  aaggtcttt  5400
ggagcgtcc  gcatgttaa  tagcgtatc  ttacatact  ctatccctt  ccatttctt  5460
ttgttccat  actcttctc  caacctgtg  ttctttttt  actgaggag  tagtcccca  5520
tagttcttg  atcacattt  catttgcac  acattactc  caggtggtg  ggagcctgg  5580
cttttgggg  accaggctg  tctggtccc  agcattgcc  cctcctagc  cctctagtc  5640
agtttgcct  ccttaccct  attttccaa  cctcttgta  cctcctctc  ctcccccag  5700
ggtatgtaa  tgtcttgaa  ttcagtatg  tatgatgga  caataattc  gcccttcgg  5760
tttctccct  cattcctgc  ccccagttt  catgtgggg  actcaactg  cattcccat  5820
gggtttccc  cccatctgc  tgatccacc  cctcctccc  ccacaagat  aattgttgg  5880
cacaattga  ctcttgtag  ggggtggct  ccagtgtgt  tgtgggggt  atcactgcc  5940
tggggagga  tggggcagg  cagagaatc  ccccaattc  tgcctgaaa  ctctggcct  6000
acccctgct  ggggttgga  tgaaaaccc  cctccccaa  ttggggggt  ttgccccat  6060
actgcccag  tcctctgac  gccccccct  aatttaggg  gggggtact  gtcactgcc  6120
atgtgtgta  gggacttgc  ggaaaacgg  gatgcttgc  cctctccag  actattgag  6180
ccagagaga  ctgtcctct  attgggtga  ctgattgag  aagggtcta  tgtcttttt  6240
aatggcaca  ttttaaggg  ttgagggta  agtccctta  cctgccacg  gagggggcc  6300
ccaaacttt  ttccccccc  cacttctgg  tttctgtgt  gagggggag  agggatatc  6360
aagctgtgg  gtgaaaggg  aggagagat  ctggaggtg  gggtgctgt  ttctagacc  6420
cccatatta  cccagtgtc  cctgccccc  tcttccccc  ccccatgcc  ccaattctg  6480
ggcgcatcc  gattgtgaa  atgtacaat  aatgtgtaa  gagtaacca  gtgttgtct  6540
agatctttt  tatttttct  ttttttttt  ttggttggg  gagaataag  tcttttctt  6600
accaatggg  ataatattg  atcggaagg  ataccagga  ggttgagaa  atacattgg  6660
aatggactg  actttgcaa  aggccctga  cttgggcag  gcaaagtgt  attctcaaa  6720
tggccacag  ggggcacta  gagttggta  tgggaagtg  catagccag  ccgtgtctc  6780
aagcccggt  cgccctatg  tctagggtt  ccagctttc  tttcccttt  ctggggcat  6840
ttcctgctg  tggactcct  tctactcct  gatttaact  ctaga  6885



<210> 3460
<211> 115
<212> PRT
<213> Homo sapiens
<308> P19065
<400> 3460

Ser Ala Thr Ala Ala Thr Ala Pro Pro Ala Ala Pro Ala Gly Glu Gly 
  1               5                  10                  15
Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln 
             20                  25                  30
Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
         35                  40                  45
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
     50                  55                  60
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
 65                  70                  75                  80
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile 
                 85                  90                  95
Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr 
             100                105                110
Phe Ser Ser 
         115



<210> 3461
<211> 1482
<212> DNA
<213> Rattus norvegicus
<308> M24104
<400> 3461

gaattcggg  tccgtctac  tcagccgca  cgtctccct  cctgtctca  tgcattctc  60
agagagggg  cggacctcc  cttcctctt  cagaaaaat  tctgctcca  ctcagccac  120
tgctgaagg  acagaaggg  ctgccccag  tgggggtcc  cctggtcct  ctcccaata  180
gaccagtaa  agacgatta  agcaaaccc  ggcacaagt  gaggaggtg  tggacatca  240
tcgcgtgaa  gtggacaag  tcttggaga  ggaccagaa  ttgtcagag  tggatgacc  300
agctgacgc  ttgcaggca  gagcgtcag  gtttgagag  agtgctgcc  agctaaaaa  360
gaagtattg  tggaaaaac  gcaagatga  gatcatgct  ggagctatc  gtgccatca  420
cgtggtagt  attgtaatc  acattttta  ttgagaatg  gccatccct  ccctgttct  480
cattgccat  caagctcat  tttcccctc  gtttgctct  tcaacaaag  cctccatct  540
ccgttctcc  tcctggccc  ggcttctct  tgatccgac  ttccctttt  gtgcattca  600
tcgcactct  cctcaaaac  agaaatgct  ctcgtggca  agtcctgaa  gtcactgcc  660
gaagagaac  cccagcacc  cctctttac  catttatca  gtgccctgg  gcttaaaag  720
gttgtggcc  atggcagag  tgaagtgtc  gagaagtta  catggctga  gggaagaga  780
aggcatttg  gtccaagaa  ggctggcct  tggcaggag  gaagcaaga  tagttggga  840
gtagtagct  gctgccagt  tatatgtat  tgtatatgt  tatgtatat  tatatgtat  900
tgtatatgt  tatattagt  gggaactat  acctgctgt  ctcatttgg  actttcctc  960
cataccagg  ctgtcttgg  tcccagagg  ctgtttaaa  accaacttc  aatcccttt  1020
agaaaaaca  caaacttgc  ttttgtagc  actgttatc  gtcagtaca  gattttctg  1080
gtctttggg  gaactttac  acttttcgc  ttgtctcta  agccccagg  gagaagtac  1140
ttctgattt  aaaaacagc  ggacactct  accttcttc  agaaggcgt  ccacatgct  1200
ctgactaga  ggagctacc  cctcttcat  tcatctgaa  catttgatg  tgttcatga  1260
ggcaccaaa  aatttcagg  aatgagggg  tttgaggat  acaggctct  aggaacacg  1320
tccatgcca  cccactctc  aatgaaagc  ctgtacctc  cttgttgat  aagagaaat  1380
agagttata  ggtgagact  ccagggtcc  acagaacac  tccccctgc  ctacccact  1440
actgtgtgt  agacaagga  gaggcagga  ggccccgaa  tc  1482



<210> 3462
<211> 115
<212> PRT
<213> Rattus norvegicus
<308> Q64357
<400> 3462

Ser Ala Thr Ala Ala Thr Val Pro Pro Ala Ala Pro Ala Gly Glu Gly 
  1               5                  10                  15
Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln 
             20                  25                  30
Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
         35                  40                  45
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
     50                  55                  60
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
 65                  70                  75                  80
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile 
                 85                  90                  95
Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr 
             100                105                110
Phe Ser Thr 
         115



<210> 3463
<211> 6885
<212> DNA
<213> Homo sapiens
<308> AF135372
<400> 3463

tcaagacca  cctggctaa  acggtgaaa  cctgtctct  ctaaaaata  aaaaaatta  60
ccgggcggg  tggtgggcg  ctgtagtcc  agctactcg  gaggctgag  gaggagaat  120
gcgtgaacc  gggaggcgg  gtttgcagt  agcagagat  gcgccattg  actccagcc  180
gggtgacag  cagagactc  gtctcaaaa  agaaaaaaa  agaaaaaaa  aaaaagaaa  240
tgtggtctc  gttgcctac  tcaccatca  cttgagtcc  acatccttt  aatgagtct  300
gggggtgtg  cctagaaaa  cattggcca  ttcccgaag  cagtacatg  agaagccaa  360
tctgagtta  gcaaataca  tatttttct  ttgttcaac  tacctctat  tgggtctcc  420
ttctacctg  ctgcaagaa  acattctct  agtcacttc  aggtgaact  cgtcatccc  480
ctccttctc  cacctccac  attgatcta  atttgggga  ttcctctga  ccacagcct  540
ggtggggtg  ggtgggaag  ggctgctgg  tgagagtcc  ctttctgag  tgaatcctc  600
tgggccctt  atctccgtg  gtcacacat  ccctcattt  tactctgct  ctgccgtcc  660
cacgatcca  tagcaatag  acgacccct  gccttgacc  tgtatctgg  gctctgtcc  720
ttccacatc  cccccaaac  agcatcaaa  gtcttgtct  gctctgcac  aggctcccc  780
cagttagtg  aggggtgtc  aactggggg  ggaagggct  cctgtgcct  cctcttcca  840
tcctccatg  cttatttat  ccctgacag  catgaaggg  tttgaactt  aaaggctgg  900
aatttggca  cttttgttc  ctgactaag  aagaggaaa  catttcaag  ccaaaaagc  960
gggagccag  atctcacag  atggatctg  gaccccccg  ggaagctgc  cttttcttt  1020
tcatcacat  agcgtgagc  cgggactgt  agtgcacaa  gaccaggga  gcggctgct  1080
ctctgaggg  gaggaagcc  agagtatct  ctcttagat  gggctgagt  cccacaccc  1140
gcacacaca  tccctgctc  ctcacctcc  acagacagc  gggaaatga  acctctggt  1200
acagagcca  tctccgggc  tctgtgggg  gcgggtggg  cactgcagt  ggggaggat  1260
tcacacccg  aggccctgg  aagccaggg  gggggaggg  ggaagctgg  tcctgtttg  1320
cttagagat  aaggccatc  gcctccctg  accttccag  gatgtagta  gcaccccca  1380
cccagggcc  aagggcctc  cctaaaatg  ctcctgcac  cttgaggct  gctttgacc  1440
cctgcactc  accaagagc  acagctccc  tgggtccca  cttctctga  aagctgggt  1500
ggagtgtat  cagctgctg  gtgtgctta  agggcctaa  ggagaccag  cagggataa  1560
ctcctatgt  atccacatc  agccattta  caaatatgg  tttagtacc  acatatgca  1620
tgtatttgg  gtccagaga  aggagggca  cggtccaag  tcacacctg  gaggcgaat  1680
cgcatgtaa  gcagcacct  gtaacctgt  cccactgtg  ctactacta  agaaaaata  1740
atgagagaa  aagaaaaaa  gcttttttt  tttttggcc  aggccctgt  cctgggacc  1800
aagcctgag  cctttcctg  agtcgggtc  ctgacctaa  cctggggca  agctaggtc  1860
tggccagtc  gcagccacc  cgtgaagca  cccctgccc  catcacccc  ggcagcctt  1920
tgccctcct  ctcggggtc  tcagctcac  ccacctcag  cgggcctgc  ccagcggtt  1980
agtacccct  gtctgaacc  taatcgtga  gcggggcag  cccctcccc  caccctgta  2040
acactcccc  gtcctccgc  ccctggact  gtttgggcg  gaagagcct  cctcatctt  2100
tcttcctac  ctcctaccc  gtggccagg  accccaggc  tcctctgag  catccacca  2160
cggtgatgg  ttgggacca  tctccccca  tcctctcca  cctagcagt  aggtccccg  2220
tctcgatac  gccccagca  ctgcactgg  cctctctga  ttcccaact  cagcccatt  2280
caagtgctg  aggcgggtc  ctaggtgct  ggacctggg  gcggggcaa  accttgggc  2340
gtgtggggt  caggctggg  ttactgggt  cacgattga  ggagtggtc  gggggttag  2400
tgtagggcc  ggctgcgtt  tgctctaag  ggcaggcgg  aggcggttt  ggggggctg  2460
ggtcagaca  ggtggggtg  cggtgggtt  ggggaagcc  cagcagccc  ccttggggt  2520
ccgcgagtg  cgagggagc  gccggggca  ggtggcgcg  ggcccgtgg  cctgcccgg  2580
acgaccccc  ccccgcagc  ccccgcagc  ccccgcccc  gcggccccg  tcgcgacgc  2640
tctcccgcg  cgccccgcc  ccgcccgca  tgcccggat  cgggtgacg  gcggccgcc  2700
tctttccgt  ccgggcagc  agcgccagt  ggagccagc  cgagcgccg  cgccatcac  2760
gccgctgcc  agtcctcca  ccgctgccc  cgccatgtg  gtcggccgc  cgccaccct  2820
accgcgctt  cctgcgccg  ccgccgccc  tggcaaccg  ccgtcggga  tgcccgggg  2880
ctcttctgc  ttccccgcg  cccggggcc  ggcccaagc  ggtgactgc  cgcgggcgg  2940
cgaggagcc  cgcgtcccg  gctggccgg  tcgggcgat  gccgcggga  ggagcggac  3000
cagtgtcct  ctgcccctc  ccgcccctg  caccgcggc  gcctgtctt  tcgggtcga  3060
ccggatcgc  tctgtgagg  cgccctcag  tgacaggcg  ggaaactga  gccgggggg  3120
cctcgctca  ggtcacgca  ctcatcggc  gcagggctg  accgagacc  gggcttaca  3180
cgggtggcc  tcctcccga  aaggaggac  ggagggacn  ggatggaca  gtggatggg  3240
ggagccctg  ctgcggggc  gggaggctg  aagccctgg  tcttaatcc  tccctgctc  3300
tcaggtctg  taccgctgc  acggccccc  ctgctgccc  ggctgggga  ggtggtccc  3360
ctgcacccc  tccaaacct  accagtaac  ggagactgc  gcagaccca  gcccaggtg  3420
atgaggtga  tgtgggggg  gtcaaaacc  gtaggaggg  ccctggggg  tggggatag  3480
tgtaggggc  cattttggt  tgggagtga  gacagttca  gcctttggg  ttgcggaca  3540
agataccat  ccccatccc  gtctccctg  cagcacgca  ttggaaggg  gctgggggt  3600
ttaatcagc  ttgctagcc  ggggtgtgc  agcctgggc  ggtgtgctc  ggtgatgga  3660
agagcgcct  aggttccat  gagggaggg  gttgctatg  catntgaga  gtcaccagc  3720
tgcccctga  gtgtgctcc  tgcatgtcc  caggtgtgc  aggcatgtt  tgtgtgtcc  3780
tggcatgtt  acctggcag  atcagggtg  atgttccat  tgtggcacg  tgggcacat  3840
tttgaggat  gccctcact  aggtgggcc  tggcacacc  ccctgcctc  tgggccctt  3900
tcccaggtg  tggacatca  gagggtgaa  gtggacaag  tcctggagc  agaccagaa  3960
ctgtcggag  tggacgacc  tgcagatgc  ctccaggcg  gggcctccc  gtttgaaac  4020
agcgcagcc  agctcaagc  caaatactg  tggaaaaac  tcaaggtaa  ggtggggac  4080
ggaaggagg  caggtgggt  aatggggta  catagtttg  cttactgat  ctcgcctct  4140
acccccaga  gatgatcat  ttgggagtg  tttgcgcca  catcctcat  atcatcata  4200
gtgagtagg  tgagaatgg  cggggccct  tccctggag  ggtttcccc  gtggattct  4260
ggttttgaa  gtcattaat  tagttttta  tcttcagcc  aaaacacat  tagctgcta  4320
tggcaattc  gattcatct  gagccaaaa  ctttgatgt  atttagcct  cattttgcc  4380
agttcttgg  agtcttgtt  acatttgga  ataggaaag  tggtgtatc  attgaggac  4440
ctttaggcc  aagagccca  tctgagaac  ctggaattg  ggagtggga  aaaggaaag  4500
accaggggc  tgagacatg  ccaggaagc  aaccacccc  ttatttgag  gcttgcggt  4560
tcagaggct  agaggatta  ggtctgtgg  ttcaaggcc  taccatgga  cggaaggga  4620
ctcagaacc  acctgtcta  ccccttgct  tgtagatgg  aaaactgag  ccaagagag  4680
gtgtcagcc  gctggggag  ggggaggat  ggagcaggg  caggcctga  acactgctt  4740
cttgttctc  ctctttctc  cccctctcc  tcttcctca  cttcttccc  tctctccac  4800
gtttacttc  gctcttaaa  ccccgagga  tctgccctg  ctagagaag  gcctctccc  4860
caaccctca  ccgttcctc  acctctcag  catatcttt  agccccccc  cccctggat  4920
cgtgtgtgt  tgtgtccgt  tgtgtgtcc  cctgtaaat  gccagctgt  atttataca  4980
atataatat  atatatatt  ggtctgttt  tagttttat  actagatga  ttttccggt  5040
gtccttaac  ccccttcct  aggttccct  cacccctct  tcttgcctt  cttcccttt  5100
cctttcttc  tgactagcc  caagtccct  catttgcat  tgctatgca  tagtccctc  5160
cctttcctt  ttcttccct  agatttagc  gatccttcc  cccaccctg  ccttccttt  5220
ctctttcct  ctcactctc  ccgtcatgc  ccctctgcc  cgccctcaa  aaaaaaaaa  5280
aaaaaaaaa  aaaaaaaaa  caccagcac  tgtccaggc  tccttaggt  catcttctt  5340
gtatccatt  ggaggctct  agactggcc  cacttggtc  taaaaatcc  aaggtcttt  5400
ggagcgtcc  gcatgttaa  tagcgtatc  ttacatact  ctatccctt  ccatttctt  5460
ttgttccat  actcttctc  caacctgtg  ttctttttt  actgaggag  tagtcccca  5520
tagttcttg  atcacattt  catttgcac  acattactc  caggtggtg  ggagcctgg  5580
cttttgggg  accaggctg  tctggtccc  agcattgcc  cctcctagc  cctctagtc  5640
agtttgcct  ccttaccct  attttccaa  cctcttgta  cctcctctc  ctcccccag  5700
ggtatgtaa  tgtcttgaa  ttcagtatg  tatgatgga  caataattc  gcccttcgg  5760
tttctccct  cattcctgc  ccccagttt  catgtgggg  actcaactg  cattcccat  5820
gggtttccc  cccatctgc  tgatccacc  cctcctccc  ccacaagat  aattgttgg  5880
cacaattga  ctcttgtag  ggggtggct  ccagtgtgt  tgtgggggt  atcactgcc  5940
tggggagga  tggggcagg  cagagaatc  ccccaattc  tgcctgaaa  ctctggcct  6000
acccctgct  ggggttgga  tgaaaaccc  cctccccaa  ttggggggt  ttgccccat  6060
actgcccag  tcctctgac  gccccccct  aatttaggg  gggggtact  gtcactgcc  6120
atgtgtgta  gggacttgc  ggaaaacgg  gatgcttgc  cctctccag  actattgag  6180
ccagagaga  ctgtcctct  attgggtga  ctgattgag  aagggtcta  tgtcttttt  6240
aatggcaca  ttttaaggg  ttgagggta  agtccctta  cctgccacg  gagggggcc  6300
ccaaacttt  ttccccccc  cacttctgg  tttctgtgt  gagggggag  agggatatc  6360
aagctgtgg  gtgaaaggg  aggagagat  ctggaggtg  gggtgctgt  ttctagacc  6420
cccatatta  cccagtgtc  cctgccccc  tcttccccc  ccccatgcc  ccaattctg  6480
ggcgcatcc  gattgtgaa  atgtacaat  aatgtgtaa  gagtaacca  gtgttgtct  6540
agatctttt  tatttttct  ttttttttt  ttggttggg  gagaataag  tcttttctt  6600
accaatggg  ataatattg  atcggaagg  ataccagga  ggttgagaa  atacattgg  6660
aatggactg  actttgcaa  aggccctga  cttgggcag  gcaaagtgt  attctcaaa  6720
tggccacag  ggggcacta  gagttggta  tgggaagtg  catagccag  ccgtgtctc  6780
aagcccggt  cgccctatg  tctagggtt  ccagctttc  tttcccttt  ctggggcat  6840
ttcctgctg  tggactcct  tctactcct  gatttaact  ctaga  6885



<210> 3464
<211> 115
<212> PRT
<213> Homo sapiens
<308> P19065
<400> 3464

Ser Ala Thr Ala Ala Thr Ala Pro Pro Ala Ala Pro Ala Gly Glu Gly 
  1               5                  10                  15
Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln 
             20                  25                  30
Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
         35                  40                  45
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
     50                  55                  60
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
 65                  70                  75                  80
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile 
                 85                  90                  95
Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr 
             100                105                110
Phe Ser Ser 
         115



<210> 3465
<211> 1482
<212> DNA
<213> Rattus norvegicus
<308> M24104
<400> 3465

gaattcggg  tccgtctac  tcagccgca  cgtctccct  cctgtctca  tgcattctc  60
agagagggg  cggacctcc  cttcctctt  cagaaaaat  tctgctcca  ctcagccac  120
tgctgaagg  acagaaggg  ctgccccag  tgggggtcc  cctggtcct  ctcccaata  180
gaccagtaa  agacgatta  agcaaaccc  ggcacaagt  gaggaggtg  tggacatca  240
tcgcgtgaa  gtggacaag  tcttggaga  ggaccagaa  ttgtcagag  tggatgacc  300
agctgacgc  ttgcaggca  gagcgtcag  gtttgagag  agtgctgcc  agctaaaaa  360
gaagtattg  tggaaaaac  gcaagatga  gatcatgct  ggagctatc  gtgccatca  420
cgtggtagt  attgtaatc  acattttta  ttgagaatg  gccatccct  ccctgttct  480
cattgccat  caagctcat  tttcccctc  gtttgctct  tcaacaaag  cctccatct  540
ccgttctcc  tcctggccc  ggcttctct  tgatccgac  ttccctttt  gtgcattca  600
tcgcactct  cctcaaaac  agaaatgct  ctcgtggca  agtcctgaa  gtcactgcc  660
gaagagaac  cccagcacc  cctctttac  catttatca  gtgccctgg  gcttaaaag  720
gttgtggcc  atggcagag  tgaagtgtc  gagaagtta  catggctga  gggaagaga  780
aggcatttg  gtccaagaa  ggctggcct  tggcaggag  gaagcaaga  tagttggga  840
gtagtagct  gctgccagt  tatatgtat  tgtatatgt  tatgtatat  tatatgtat  900
tgtatatgt  tatattagt  gggaactat  acctgctgt  ctcatttgg  actttcctc  960
cataccagg  ctgtcttgg  tcccagagg  ctgtttaaa  accaacttc  aatcccttt  1020
agaaaaaca  caaacttgc  ttttgtagc  actgttatc  gtcagtaca  gattttctg  1080
gtctttggg  gaactttac  acttttcgc  ttgtctcta  agccccagg  gagaagtac  1140
ttctgattt  aaaaacagc  ggacactct  accttcttc  agaaggcgt  ccacatgct  1200
ctgactaga  ggagctacc  cctcttcat  tcatctgaa  catttgatg  tgttcatga  1260
ggcaccaaa  aatttcagg  aatgagggg  tttgaggat  acaggctct  aggaacacg  1320
tccatgcca  cccactctc  aatgaaagc  ctgtacctc  cttgttgat  aagagaaat  1380
agagttata  ggtgagact  ccagggtcc  acagaacac  tccccctgc  ctacccact  1440
actgtgtgt  agacaagga  gaggcagga  ggccccgaa  tc  1482



<210> 3466
<211> 115
<212> PRT
<213> Rattus norvegicus
<308> Q64357
<400> 3466

Ser Ala Thr Ala Ala Thr Val Pro Pro Ala Ala Pro Ala Gly Glu Gly 
  1               5                  10                  15
Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln 
             20                  25                  30
Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
         35                  40                  45
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
     50                  55                  60
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
 65                  70                  75                  80
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile 
                 85                  90                  95
Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr 
             100                105                110
Phe Ser Thr 
         115



<210> 3467
<211> 6885
<212> DNA
<213> Homo sapiens
<308> AF135372
<400> 3467

tcaagacca  cctggctaa  acggtgaaa  cctgtctct  ctaaaaata  aaaaaatta  60
ccgggcggg  tggtgggcg  ctgtagtcc  agctactcg  gaggctgag  gaggagaat  120
gcgtgaacc  gggaggcgg  gtttgcagt  agcagagat  gcgccattg  actccagcc  180
gggtgacag  cagagactc  gtctcaaaa  agaaaaaaa  agaaaaaaa  aaaaagaaa  240
tgtggtctc  gttgcctac  tcaccatca  cttgagtcc  acatccttt  aatgagtct  300
gggggtgtg  cctagaaaa  cattggcca  ttcccgaag  cagtacatg  agaagccaa  360
tctgagtta  gcaaataca  tatttttct  ttgttcaac  tacctctat  tgggtctcc  420
ttctacctg  ctgcaagaa  acattctct  agtcacttc  aggtgaact  cgtcatccc  480
ctccttctc  cacctccac  attgatcta  atttgggga  ttcctctga  ccacagcct  540
ggtggggtg  ggtgggaag  ggctgctgg  tgagagtcc  ctttctgag  tgaatcctc  600
tgggccctt  atctccgtg  gtcacacat  ccctcattt  tactctgct  ctgccgtcc  660
cacgatcca  tagcaatag  acgacccct  gccttgacc  tgtatctgg  gctctgtcc  720
ttccacatc  cccccaaac  agcatcaaa  gtcttgtct  gctctgcac  aggctcccc  780
cagttagtg  aggggtgtc  aactggggg  ggaagggct  cctgtgcct  cctcttcca  840
tcctccatg  cttatttat  ccctgacag  catgaaggg  tttgaactt  aaaggctgg  900
aatttggca  cttttgttc  ctgactaag  aagaggaaa  catttcaag  ccaaaaagc  960
gggagccag  atctcacag  atggatctg  gaccccccg  ggaagctgc  cttttcttt  1020
tcatcacat  agcgtgagc  cgggactgt  agtgcacaa  gaccaggga  gcggctgct  1080
ctctgaggg  gaggaagcc  agagtatct  ctcttagat  gggctgagt  cccacaccc  1140
gcacacaca  tccctgctc  ctcacctcc  acagacagc  gggaaatga  acctctggt  1200
acagagcca  tctccgggc  tctgtgggg  gcgggtggg  cactgcagt  ggggaggat  1260
tcacacccg  aggccctgg  aagccaggg  gggggaggg  ggaagctgg  tcctgtttg  1320
cttagagat  aaggccatc  gcctccctg  accttccag  gatgtagta  gcaccccca  1380
cccagggcc  aagggcctc  cctaaaatg  ctcctgcac  cttgaggct  gctttgacc  1440
cctgcactc  accaagagc  acagctccc  tgggtccca  cttctctga  aagctgggt  1500
ggagtgtat  cagctgctg  gtgtgctta  agggcctaa  ggagaccag  cagggataa  1560
ctcctatgt  atccacatc  agccattta  caaatatgg  tttagtacc  acatatgca  1620
tgtatttgg  gtccagaga  aggagggca  cggtccaag  tcacacctg  gaggcgaat  1680
cgcatgtaa  gcagcacct  gtaacctgt  cccactgtg  ctactacta  agaaaaata  1740
atgagagaa  aagaaaaaa  gcttttttt  tttttggcc  aggccctgt  cctgggacc  1800
aagcctgag  cctttcctg  agtcgggtc  ctgacctaa  cctggggca  agctaggtc  1860
tggccagtc  gcagccacc  cgtgaagca  cccctgccc  catcacccc  ggcagcctt  1920
tgccctcct  ctcggggtc  tcagctcac  ccacctcag  cgggcctgc  ccagcggtt  1980
agtacccct  gtctgaacc  taatcgtga  gcggggcag  cccctcccc  caccctgta  2040
acactcccc  gtcctccgc  ccctggact  gtttgggcg  gaagagcct  cctcatctt  2100
tcttcctac  ctcctaccc  gtggccagg  accccaggc  tcctctgag  catccacca  2160
cggtgatgg  ttgggacca  tctccccca  tcctctcca  cctagcagt  aggtccccg  2220
tctcgatac  gccccagca  ctgcactgg  cctctctga  ttcccaact  cagcccatt  2280
caagtgctg  aggcgggtc  ctaggtgct  ggacctggg  gcggggcaa  accttgggc  2340
gtgtggggt  caggctggg  ttactgggt  cacgattga  ggagtggtc  gggggttag  2400
tgtagggcc  ggctgcgtt  tgctctaag  ggcaggcgg  aggcggttt  ggggggctg  2460
ggtcagaca  ggtggggtg  cggtgggtt  ggggaagcc  cagcagccc  ccttggggt  2520
ccgcgagtg  cgagggagc  gccggggca  ggtggcgcg  ggcccgtgg  cctgcccgg  2580
acgaccccc  ccccgcagc  ccccgcagc  ccccgcccc  gcggccccg  tcgcgacgc  2640
tctcccgcg  cgccccgcc  ccgcccgca  tgcccggat  cgggtgacg  gcggccgcc  2700
tctttccgt  ccgggcagc  agcgccagt  ggagccagc  cgagcgccg  cgccatcac  2760
gccgctgcc  agtcctcca  ccgctgccc  cgccatgtg  gtcggccgc  cgccaccct  2820
accgcgctt  cctgcgccg  ccgccgccc  tggcaaccg  ccgtcggga  tgcccgggg  2880
ctcttctgc  ttccccgcg  cccggggcc  ggcccaagc  ggtgactgc  cgcgggcgg  2940
cgaggagcc  cgcgtcccg  gctggccgg  tcgggcgat  gccgcggga  ggagcggac  3000
cagtgtcct  ctgcccctc  ccgcccctg  caccgcggc  gcctgtctt  tcgggtcga  3060
ccggatcgc  tctgtgagg  cgccctcag  tgacaggcg  ggaaactga  gccgggggg  3120
cctcgctca  ggtcacgca  ctcatcggc  gcagggctg  accgagacc  gggcttaca  3180
cgggtggcc  tcctcccga  aaggaggac  ggagggacn  ggatggaca  gtggatggg  3240
ggagccctg  ctgcggggc  gggaggctg  aagccctgg  tcttaatcc  tccctgctc  3300
tcaggtctg  taccgctgc  acggccccc  ctgctgccc  ggctgggga  ggtggtccc  3360
ctgcacccc  tccaaacct  accagtaac  ggagactgc  gcagaccca  gcccaggtg  3420
atgaggtga  tgtgggggg  gtcaaaacc  gtaggaggg  ccctggggg  tggggatag  3480
tgtaggggc  cattttggt  tgggagtga  gacagttca  gcctttggg  ttgcggaca  3540
agataccat  ccccatccc  gtctccctg  cagcacgca  ttggaaggg  gctgggggt  3600
ttaatcagc  ttgctagcc  ggggtgtgc  agcctgggc  ggtgtgctc  ggtgatgga  3660
agagcgcct  aggttccat  gagggaggg  gttgctatg  catntgaga  gtcaccagc  3720
tgcccctga  gtgtgctcc  tgcatgtcc  caggtgtgc  aggcatgtt  tgtgtgtcc  3780
tggcatgtt  acctggcag  atcagggtg  atgttccat  tgtggcacg  tgggcacat  3840
tttgaggat  gccctcact  aggtgggcc  tggcacacc  ccctgcctc  tgggccctt  3900
tcccaggtg  tggacatca  gagggtgaa  gtggacaag  tcctggagc  agaccagaa  3960
ctgtcggag  tggacgacc  tgcagatgc  ctccaggcg  gggcctccc  gtttgaaac  4020
agcgcagcc  agctcaagc  caaatactg  tggaaaaac  tcaaggtaa  ggtggggac  4080
ggaaggagg  caggtgggt  aatggggta  catagtttg  cttactgat  ctcgcctct  4140
acccccaga  gatgatcat  ttgggagtg  tttgcgcca  catcctcat  atcatcata  4200
gtgagtagg  tgagaatgg  cggggccct  tccctggag  ggtttcccc  gtggattct  4260
ggttttgaa  gtcattaat  tagttttta  tcttcagcc  aaaacacat  tagctgcta  4320
tggcaattc  gattcatct  gagccaaaa  ctttgatgt  atttagcct  cattttgcc  4380
agttcttgg  agtcttgtt  acatttgga  ataggaaag  tggtgtatc  attgaggac  4440
ctttaggcc  aagagccca  tctgagaac  ctggaattg  ggagtggga  aaaggaaag  4500
accaggggc  tgagacatg  ccaggaagc  aaccacccc  ttatttgag  gcttgcggt  4560
tcagaggct  agaggatta  ggtctgtgg  ttcaaggcc  taccatgga  cggaaggga  4620
ctcagaacc  acctgtcta  ccccttgct  tgtagatgg  aaaactgag  ccaagagag  4680
gtgtcagcc  gctggggag  ggggaggat  ggagcaggg  caggcctga  acactgctt  4740
cttgttctc  ctctttctc  cccctctcc  tcttcctca  cttcttccc  tctctccac  4800
gtttacttc  gctcttaaa  ccccgagga  tctgccctg  ctagagaag  gcctctccc  4860
caaccctca  ccgttcctc  acctctcag  catatcttt  agccccccc  cccctggat  4920
cgtgtgtgt  tgtgtccgt  tgtgtgtcc  cctgtaaat  gccagctgt  atttataca  4980
atataatat  atatatatt  ggtctgttt  tagttttat  actagatga  ttttccggt  5040
gtccttaac  ccccttcct  aggttccct  cacccctct  tcttgcctt  cttcccttt  5100
cctttcttc  tgactagcc  caagtccct  catttgcat  tgctatgca  tagtccctc  5160
cctttcctt  ttcttccct  agatttagc  gatccttcc  cccaccctg  ccttccttt  5220
ctctttcct  ctcactctc  ccgtcatgc  ccctctgcc  cgccctcaa  aaaaaaaaa  5280
aaaaaaaaa  aaaaaaaaa  caccagcac  tgtccaggc  tccttaggt  catcttctt  5340
gtatccatt  ggaggctct  agactggcc  cacttggtc  taaaaatcc  aaggtcttt  5400
ggagcgtcc  gcatgttaa  tagcgtatc  ttacatact  ctatccctt  ccatttctt  5460
ttgttccat  actcttctc  caacctgtg  ttctttttt  actgaggag  tagtcccca  5520
tagttcttg  atcacattt  catttgcac  acattactc  caggtggtg  ggagcctgg  5580
cttttgggg  accaggctg  tctggtccc  agcattgcc  cctcctagc  cctctagtc  5640
agtttgcct  ccttaccct  attttccaa  cctcttgta  cctcctctc  ctcccccag  5700
ggtatgtaa  tgtcttgaa  ttcagtatg  tatgatgga  caataattc  gcccttcgg  5760
tttctccct  cattcctgc  ccccagttt  catgtgggg  actcaactg  cattcccat  5820
gggtttccc  cccatctgc  tgatccacc  cctcctccc  ccacaagat  aattgttgg  5880
cacaattga  ctcttgtag  ggggtggct  ccagtgtgt  tgtgggggt  atcactgcc  5940
tggggagga  tggggcagg  cagagaatc  ccccaattc  tgcctgaaa  ctctggcct  6000
acccctgct  ggggttgga  tgaaaaccc  cctccccaa  ttggggggt  ttgccccat  6060
actgcccag  tcctctgac  gccccccct  aatttaggg  gggggtact  gtcactgcc  6120
atgtgtgta  gggacttgc  ggaaaacgg  gatgcttgc  cctctccag  actattgag  6180
ccagagaga  ctgtcctct  attgggtga  ctgattgag  aagggtcta  tgtcttttt  6240
aatggcaca  ttttaaggg  ttgagggta  agtccctta  cctgccacg  gagggggcc  6300
ccaaacttt  ttccccccc  cacttctgg  tttctgtgt  gagggggag  agggatatc  6360
aagctgtgg  gtgaaaggg  aggagagat  ctggaggtg  gggtgctgt  ttctagacc  6420
cccatatta  cccagtgtc  cctgccccc  tcttccccc  ccccatgcc  ccaattctg  6480
ggcgcatcc  gattgtgaa  atgtacaat  aatgtgtaa  gagtaacca  gtgttgtct  6540
agatctttt  tatttttct  ttttttttt  ttggttggg  gagaataag  tcttttctt  6600
accaatggg  ataatattg  atcggaagg  ataccagga  ggttgagaa  atacattgg  6660
aatggactg  actttgcaa  aggccctga  cttgggcag  gcaaagtgt  attctcaaa  6720
tggccacag  ggggcacta  gagttggta  tgggaagtg  catagccag  ccgtgtctc  6780
aagcccggt  cgccctatg  tctagggtt  ccagctttc  tttcccttt  ctggggcat  6840
ttcctgctg  tggactcct  tctactcct  gatttaact  ctaga  6885



<210> 3468
<211> 115
<212> PRT
<213> Homo sapiens
<308> P19065
<400> 3468

Ser Ala Thr Ala Ala Thr Ala Pro Pro Ala Ala Pro Ala Gly Glu Gly 
  1               5                  10                  15
Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln 
             20                  25                  30
Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
         35                  40                  45
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
     50                  55                  60
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
 65                  70                  75                  80
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile 
                 85                  90                  95
Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr 
             100                105                110
Phe Ser Ser 
         115



<210> 3469
<211> 1482
<212> DNA
<213> Rattus norvegicus
<308> M24104
<400> 3469

gaattcggg  tccgtctac  tcagccgca  cgtctccct  cctgtctca  tgcattctc  60
agagagggg  cggacctcc  cttcctctt  cagaaaaat  tctgctcca  ctcagccac  120
tgctgaagg  acagaaggg  ctgccccag  tgggggtcc  cctggtcct  ctcccaata  180
gaccagtaa  agacgatta  agcaaaccc  ggcacaagt  gaggaggtg  tggacatca  240
tcgcgtgaa  gtggacaag  tcttggaga  ggaccagaa  ttgtcagag  tggatgacc  300
agctgacgc  ttgcaggca  gagcgtcag  gtttgagag  agtgctgcc  agctaaaaa  360
gaagtattg  tggaaaaac  gcaagatga  gatcatgct  ggagctatc  gtgccatca  420
cgtggtagt  attgtaatc  acattttta  ttgagaatg  gccatccct  ccctgttct  480
cattgccat  caagctcat  tttcccctc  gtttgctct  tcaacaaag  cctccatct  540
ccgttctcc  tcctggccc  ggcttctct  tgatccgac  ttccctttt  gtgcattca  600
tcgcactct  cctcaaaac  agaaatgct  ctcgtggca  agtcctgaa  gtcactgcc  660
gaagagaac  cccagcacc  cctctttac  catttatca  gtgccctgg  gcttaaaag  720
gttgtggcc  atggcagag  tgaagtgtc  gagaagtta  catggctga  gggaagaga  780
aggcatttg  gtccaagaa  ggctggcct  tggcaggag  gaagcaaga  tagttggga  840
gtagtagct  gctgccagt  tatatgtat  tgtatatgt  tatgtatat  tatatgtat  900
tgtatatgt  tatattagt  gggaactat  acctgctgt  ctcatttgg  actttcctc  960
cataccagg  ctgtcttgg  tcccagagg  ctgtttaaa  accaacttc  aatcccttt  1020
agaaaaaca  caaacttgc  ttttgtagc  actgttatc  gtcagtaca  gattttctg  1080
gtctttggg  gaactttac  acttttcgc  ttgtctcta  agccccagg  gagaagtac  1140
ttctgattt  aaaaacagc  ggacactct  accttcttc  agaaggcgt  ccacatgct  1200
ctgactaga  ggagctacc  cctcttcat  tcatctgaa  catttgatg  tgttcatga  1260
ggcaccaaa  aatttcagg  aatgagggg  tttgaggat  acaggctct  aggaacacg  1320
tccatgcca  cccactctc  aatgaaagc  ctgtacctc  cttgttgat  aagagaaat  1380
agagttata  ggtgagact  ccagggtcc  acagaacac  tccccctgc  ctacccact  1440
actgtgtgt  agacaagga  gaggcagga  ggccccgaa  tc  1482



<210> 3470
<211> 115
<212> PRT
<213> Rattus norvegicus
<308> Q64357
<400> 3470

Ser Ala Thr Ala Ala Thr Val Pro Pro Ala Ala Pro Ala Gly Glu Gly 
  1               5                  10                  15
Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln 
             20                  25                  30
Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
         35                  40                  45
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
     50                  55                  60
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
 65                  70                  75                  80
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile 
                 85                  90                  95
Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr 
             100                105                110
Phe Ser Thr 
         115



<210> 3471
<211> 6885
<212> DNA
<213> Homo sapiens
<308> AF135372
<400> 3471

tcaagacca  cctggctaa  acggtgaaa  cctgtctct  ctaaaaata  aaaaaatta  60
ccgggcggg  tggtgggcg  ctgtagtcc  agctactcg  gaggctgag  gaggagaat  120
gcgtgaacc  gggaggcgg  gtttgcagt  agcagagat  gcgccattg  actccagcc  180
gggtgacag  cagagactc  gtctcaaaa  agaaaaaaa  agaaaaaaa  aaaaagaaa  240
tgtggtctc  gttgcctac  tcaccatca  cttgagtcc  acatccttt  aatgagtct  300
gggggtgtg  cctagaaaa  cattggcca  ttcccgaag  cagtacatg  agaagccaa  360
tctgagtta  gcaaataca  tatttttct  ttgttcaac  tacctctat  tgggtctcc  420
ttctacctg  ctgcaagaa  acattctct  agtcacttc  aggtgaact  cgtcatccc  480
ctccttctc  cacctccac  attgatcta  atttgggga  ttcctctga  ccacagcct  540
ggtggggtg  ggtgggaag  ggctgctgg  tgagagtcc  ctttctgag  tgaatcctc  600
tgggccctt  atctccgtg  gtcacacat  ccctcattt  tactctgct  ctgccgtcc  660
cacgatcca  tagcaatag  acgacccct  gccttgacc  tgtatctgg  gctctgtcc  720
ttccacatc  cccccaaac  agcatcaaa  gtcttgtct  gctctgcac  aggctcccc  780
cagttagtg  aggggtgtc  aactggggg  ggaagggct  cctgtgcct  cctcttcca  840
tcctccatg  cttatttat  ccctgacag  catgaaggg  tttgaactt  aaaggctgg  900
aatttggca  cttttgttc  ctgactaag  aagaggaaa  catttcaag  ccaaaaagc  960
gggagccag  atctcacag  atggatctg  gaccccccg  ggaagctgc  cttttcttt  1020
tcatcacat  agcgtgagc  cgggactgt  agtgcacaa  gaccaggga  gcggctgct  1080
ctctgaggg  gaggaagcc  agagtatct  ctcttagat  gggctgagt  cccacaccc  1140
gcacacaca  tccctgctc  ctcacctcc  acagacagc  gggaaatga  acctctggt  1200
acagagcca  tctccgggc  tctgtgggg  gcgggtggg  cactgcagt  ggggaggat  1260
tcacacccg  aggccctgg  aagccaggg  gggggaggg  ggaagctgg  tcctgtttg  1320
cttagagat  aaggccatc  gcctccctg  accttccag  gatgtagta  gcaccccca  1380
cccagggcc  aagggcctc  cctaaaatg  ctcctgcac  cttgaggct  gctttgacc  1440
cctgcactc  accaagagc  acagctccc  tgggtccca  cttctctga  aagctgggt  1500
ggagtgtat  cagctgctg  gtgtgctta  agggcctaa  ggagaccag  cagggataa  1560
ctcctatgt  atccacatc  agccattta  caaatatgg  tttagtacc  acatatgca  1620
tgtatttgg  gtccagaga  aggagggca  cggtccaag  tcacacctg  gaggcgaat  1680
cgcatgtaa  gcagcacct  gtaacctgt  cccactgtg  ctactacta  agaaaaata  1740
atgagagaa  aagaaaaaa  gcttttttt  tttttggcc  aggccctgt  cctgggacc  1800
aagcctgag  cctttcctg  agtcgggtc  ctgacctaa  cctggggca  agctaggtc  1860
tggccagtc  gcagccacc  cgtgaagca  cccctgccc  catcacccc  ggcagcctt  1920
tgccctcct  ctcggggtc  tcagctcac  ccacctcag  cgggcctgc  ccagcggtt  1980
agtacccct  gtctgaacc  taatcgtga  gcggggcag  cccctcccc  caccctgta  2040
acactcccc  gtcctccgc  ccctggact  gtttgggcg  gaagagcct  cctcatctt  2100
tcttcctac  ctcctaccc  gtggccagg  accccaggc  tcctctgag  catccacca  2160
cggtgatgg  ttgggacca  tctccccca  tcctctcca  cctagcagt  aggtccccg  2220
tctcgatac  gccccagca  ctgcactgg  cctctctga  ttcccaact  cagcccatt  2280
caagtgctg  aggcgggtc  ctaggtgct  ggacctggg  gcggggcaa  accttgggc  2340
gtgtggggt  caggctggg  ttactgggt  cacgattga  ggagtggtc  gggggttag  2400
tgtagggcc  ggctgcgtt  tgctctaag  ggcaggcgg  aggcggttt  ggggggctg  2460
ggtcagaca  ggtggggtg  cggtgggtt  ggggaagcc  cagcagccc  ccttggggt  2520
ccgcgagtg  cgagggagc  gccggggca  ggtggcgcg  ggcccgtgg  cctgcccgg  2580
acgaccccc  ccccgcagc  ccccgcagc  ccccgcccc  gcggccccg  tcgcgacgc  2640
tctcccgcg  cgccccgcc  ccgcccgca  tgcccggat  cgggtgacg  gcggccgcc  2700
tctttccgt  ccgggcagc  agcgccagt  ggagccagc  cgagcgccg  cgccatcac  2760
gccgctgcc  agtcctcca  ccgctgccc  cgccatgtg  gtcggccgc  cgccaccct  2820
accgcgctt  cctgcgccg  ccgccgccc  tggcaaccg  ccgtcggga  tgcccgggg  2880
ctcttctgc  ttccccgcg  cccggggcc  ggcccaagc  ggtgactgc  cgcgggcgg  2940
cgaggagcc  cgcgtcccg  gctggccgg  tcgggcgat  gccgcggga  ggagcggac  3000
cagtgtcct  ctgcccctc  ccgcccctg  caccgcggc  gcctgtctt  tcgggtcga  3060
ccggatcgc  tctgtgagg  cgccctcag  tgacaggcg  ggaaactga  gccgggggg  3120
cctcgctca  ggtcacgca  ctcatcggc  gcagggctg  accgagacc  gggcttaca  3180
cgggtggcc  tcctcccga  aaggaggac  ggagggacn  ggatggaca  gtggatggg  3240
ggagccctg  ctgcggggc  gggaggctg  aagccctgg  tcttaatcc  tccctgctc  3300
tcaggtctg  taccgctgc  acggccccc  ctgctgccc  ggctgggga  ggtggtccc  3360
ctgcacccc  tccaaacct  accagtaac  ggagactgc  gcagaccca  gcccaggtg  3420
atgaggtga  tgtgggggg  gtcaaaacc  gtaggaggg  ccctggggg  tggggatag  3480
tgtaggggc  cattttggt  tgggagtga  gacagttca  gcctttggg  ttgcggaca  3540
agataccat  ccccatccc  gtctccctg  cagcacgca  ttggaaggg  gctgggggt  3600
ttaatcagc  ttgctagcc  ggggtgtgc  agcctgggc  ggtgtgctc  ggtgatgga  3660
agagcgcct  aggttccat  gagggaggg  gttgctatg  catntgaga  gtcaccagc  3720
tgcccctga  gtgtgctcc  tgcatgtcc  caggtgtgc  aggcatgtt  tgtgtgtcc  3780
tggcatgtt  acctggcag  atcagggtg  atgttccat  tgtggcacg  tgggcacat  3840
tttgaggat  gccctcact  aggtgggcc  tggcacacc  ccctgcctc  tgggccctt  3900
tcccaggtg  tggacatca  gagggtgaa  gtggacaag  tcctggagc  agaccagaa  3960
ctgtcggag  tggacgacc  tgcagatgc  ctccaggcg  gggcctccc  gtttgaaac  4020
agcgcagcc  agctcaagc  caaatactg  tggaaaaac  tcaaggtaa  ggtggggac  4080
ggaaggagg  caggtgggt  aatggggta  catagtttg  cttactgat  ctcgcctct  4140
acccccaga  gatgatcat  ttgggagtg  tttgcgcca  catcctcat  atcatcata  4200
gtgagtagg  tgagaatgg  cggggccct  tccctggag  ggtttcccc  gtggattct  4260
ggttttgaa  gtcattaat  tagttttta  tcttcagcc  aaaacacat  tagctgcta  4320
tggcaattc  gattcatct  gagccaaaa  ctttgatgt  atttagcct  cattttgcc  4380
agttcttgg  agtcttgtt  acatttgga  ataggaaag  tggtgtatc  attgaggac  4440
ctttaggcc  aagagccca  tctgagaac  ctggaattg  ggagtggga  aaaggaaag  4500
accaggggc  tgagacatg  ccaggaagc  aaccacccc  ttatttgag  gcttgcggt  4560
tcagaggct  agaggatta  ggtctgtgg  ttcaaggcc  taccatgga  cggaaggga  4620
ctcagaacc  acctgtcta  ccccttgct  tgtagatgg  aaaactgag  ccaagagag  4680
gtgtcagcc  gctggggag  ggggaggat  ggagcaggg  caggcctga  acactgctt  4740
cttgttctc  ctctttctc  cccctctcc  tcttcctca  cttcttccc  tctctccac  4800
gtttacttc  gctcttaaa  ccccgagga  tctgccctg  ctagagaag  gcctctccc  4860
caaccctca  ccgttcctc  acctctcag  catatcttt  agccccccc  cccctggat  4920
cgtgtgtgt  tgtgtccgt  tgtgtgtcc  cctgtaaat  gccagctgt  atttataca  4980
atataatat  atatatatt  ggtctgttt  tagttttat  actagatga  ttttccggt  5040
gtccttaac  ccccttcct  aggttccct  cacccctct  tcttgcctt  cttcccttt  5100
cctttcttc  tgactagcc  caagtccct  catttgcat  tgctatgca  tagtccctc  5160
cctttcctt  ttcttccct  agatttagc  gatccttcc  cccaccctg  ccttccttt  5220
ctctttcct  ctcactctc  ccgtcatgc  ccctctgcc  cgccctcaa  aaaaaaaaa  5280
aaaaaaaaa  aaaaaaaaa  caccagcac  tgtccaggc  tccttaggt  catcttctt  5340
gtatccatt  ggaggctct  agactggcc  cacttggtc  taaaaatcc  aaggtcttt  5400
ggagcgtcc  gcatgttaa  tagcgtatc  ttacatact  ctatccctt  ccatttctt  5460
ttgttccat  actcttctc  caacctgtg  ttctttttt  actgaggag  tagtcccca  5520
tagttcttg  atcacattt  catttgcac  acattactc  caggtggtg  ggagcctgg  5580
cttttgggg  accaggctg  tctggtccc  agcattgcc  cctcctagc  cctctagtc  5640
agtttgcct  ccttaccct  attttccaa  cctcttgta  cctcctctc  ctcccccag  5700
ggtatgtaa  tgtcttgaa  ttcagtatg  tatgatgga  caataattc  gcccttcgg  5760
tttctccct  cattcctgc  ccccagttt  catgtgggg  actcaactg  cattcccat  5820
gggtttccc  cccatctgc  tgatccacc  cctcctccc  ccacaagat  aattgttgg  5880
cacaattga  ctcttgtag  ggggtggct  ccagtgtgt  tgtgggggt  atcactgcc  5940
tggggagga  tggggcagg  cagagaatc  ccccaattc  tgcctgaaa  ctctggcct  6000
acccctgct  ggggttgga  tgaaaaccc  cctccccaa  ttggggggt  ttgccccat  6060
actgcccag  tcctctgac  gccccccct  aatttaggg  gggggtact  gtcactgcc  6120
atgtgtgta  gggacttgc  ggaaaacgg  gatgcttgc  cctctccag  actattgag  6180
ccagagaga  ctgtcctct  attgggtga  ctgattgag  aagggtcta  tgtcttttt  6240
aatggcaca  ttttaaggg  ttgagggta  agtccctta  cctgccacg  gagggggcc  6300
ccaaacttt  ttccccccc  cacttctgg  tttctgtgt  gagggggag  agggatatc  6360
aagctgtgg  gtgaaaggg  aggagagat  ctggaggtg  gggtgctgt  ttctagacc  6420
cccatatta  cccagtgtc  cctgccccc  tcttccccc  ccccatgcc  ccaattctg  6480
ggcgcatcc  gattgtgaa  atgtacaat  aatgtgtaa  gagtaacca  gtgttgtct  6540
agatctttt  tatttttct  ttttttttt  ttggttggg  gagaataag  tcttttctt  6600
accaatggg  ataatattg  atcggaagg  ataccagga  ggttgagaa  atacattgg  6660
aatggactg  actttgcaa  aggccctga  cttgggcag  gcaaagtgt  attctcaaa  6720
tggccacag  ggggcacta  gagttggta  tgggaagtg  catagccag  ccgtgtctc  6780
aagcccggt  cgccctatg  tctagggtt  ccagctttc  tttcccttt  ctggggcat  6840
ttcctgctg  tggactcct  tctactcct  gatttaact  ctaga  6885



<210> 3472
<211> 115
<212> PRT
<213> Homo sapiens
<308> P19065
<400> 3472

Ser Ala Thr Ala Ala Thr Ala Pro Pro Ala Ala Pro Ala Gly Glu Gly 
  1               5                  10                  15
Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln 
             20                  25                  30
Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
         35                  40                  45
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
     50                  55                  60
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
 65                  70                  75                  80
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile 
                 85                  90                  95
Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr 
             100                105                110
Phe Ser Ser 
         115



<210> 3473
<211> 1482
<212> DNA
<213> Rattus norvegicus
<308> M24104
<400> 3473

gaattcggg  tccgtctac  tcagccgca  cgtctccct  cctgtctca  tgcattctc  60
agagagggg  cggacctcc  cttcctctt  cagaaaaat  tctgctcca  ctcagccac  120
tgctgaagg  acagaaggg  ctgccccag  tgggggtcc  cctggtcct  ctcccaata  180
gaccagtaa  agacgatta  agcaaaccc  ggcacaagt  gaggaggtg  tggacatca  240
tcgcgtgaa  gtggacaag  tcttggaga  ggaccagaa  ttgtcagag  tggatgacc  300
agctgacgc  ttgcaggca  gagcgtcag  gtttgagag  agtgctgcc  agctaaaaa  360
gaagtattg  tggaaaaac  gcaagatga  gatcatgct  ggagctatc  gtgccatca  420
cgtggtagt  attgtaatc  acattttta  ttgagaatg  gccatccct  ccctgttct  480
cattgccat  caagctcat  tttcccctc  gtttgctct  tcaacaaag  cctccatct  540
ccgttctcc  tcctggccc  ggcttctct  tgatccgac  ttccctttt  gtgcattca  600
tcgcactct  cctcaaaac  agaaatgct  ctcgtggca  agtcctgaa  gtcactgcc  660
gaagagaac  cccagcacc  cctctttac  catttatca  gtgccctgg  gcttaaaag  720
gttgtggcc  atggcagag  tgaagtgtc  gagaagtta  catggctga  gggaagaga  780
aggcatttg  gtccaagaa  ggctggcct  tggcaggag  gaagcaaga  tagttggga  840
gtagtagct  gctgccagt  tatatgtat  tgtatatgt  tatgtatat  tatatgtat  900
tgtatatgt  tatattagt  gggaactat  acctgctgt  ctcatttgg  actttcctc  960
cataccagg  ctgtcttgg  tcccagagg  ctgtttaaa  accaacttc  aatcccttt  1020
agaaaaaca  caaacttgc  ttttgtagc  actgttatc  gtcagtaca  gattttctg  1080
gtctttggg  gaactttac  acttttcgc  ttgtctcta  agccccagg  gagaagtac  1140
ttctgattt  aaaaacagc  ggacactct  accttcttc  agaaggcgt  ccacatgct  1200
ctgactaga  ggagctacc  cctcttcat  tcatctgaa  catttgatg  tgttcatga  1260
ggcaccaaa  aatttcagg  aatgagggg  tttgaggat  acaggctct  aggaacacg  1320
tccatgcca  cccactctc  aatgaaagc  ctgtacctc  cttgttgat  aagagaaat  1380
agagttata  ggtgagact  ccagggtcc  acagaacac  tccccctgc  ctacccact  1440
actgtgtgt  agacaagga  gaggcagga  ggccccgaa  tc  1482



<210> 3474
<211> 115
<212> PRT
<213> Rattus norvegicus
<308> Q64357
<400> 3474

Ser Ala Thr Ala Ala Thr Val Pro Pro Ala Ala Pro Ala Gly Glu Gly 
  1               5                  10                  15
Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln 
             20                  25                  30
Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
         35                  40                  45
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
     50                  55                  60
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
 65                  70                  75                  80
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile 
                 85                  90                  95
Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr 
             100                105                110
Phe Ser Thr 
         115



<210> 3475
<211> 6885
<212> DNA
<213> Homo sapiens
<308> AF135372
<400> 3475

tcaagacca  cctggctaa  acggtgaaa  cctgtctct  ctaaaaata  aaaaaatta  60
ccgggcggg  tggtgggcg  ctgtagtcc  agctactcg  gaggctgag  gaggagaat  120
gcgtgaacc  gggaggcgg  gtttgcagt  agcagagat  gcgccattg  actccagcc  180
gggtgacag  cagagactc  gtctcaaaa  agaaaaaaa  agaaaaaaa  aaaaagaaa  240
tgtggtctc  gttgcctac  tcaccatca  cttgagtcc  acatccttt  aatgagtct  300
gggggtgtg  cctagaaaa  cattggcca  ttcccgaag  cagtacatg  agaagccaa  360
tctgagtta  gcaaataca  tatttttct  ttgttcaac  tacctctat  tgggtctcc  420
ttctacctg  ctgcaagaa  acattctct  agtcacttc  aggtgaact  cgtcatccc  480
ctccttctc  cacctccac  attgatcta  atttgggga  ttcctctga  ccacagcct  540
ggtggggtg  ggtgggaag  ggctgctgg  tgagagtcc  ctttctgag  tgaatcctc  600
tgggccctt  atctccgtg  gtcacacat  ccctcattt  tactctgct  ctgccgtcc  660
cacgatcca  tagcaatag  acgacccct  gccttgacc  tgtatctgg  gctctgtcc  720
ttccacatc  cccccaaac  agcatcaaa  gtcttgtct  gctctgcac  aggctcccc  780
cagttagtg  aggggtgtc  aactggggg  ggaagggct  cctgtgcct  cctcttcca  840
tcctccatg  cttatttat  ccctgacag  catgaaggg  tttgaactt  aaaggctgg  900
aatttggca  cttttgttc  ctgactaag  aagaggaaa  catttcaag  ccaaaaagc  960
gggagccag  atctcacag  atggatctg  gaccccccg  ggaagctgc  cttttcttt  1020
tcatcacat  agcgtgagc  cgggactgt  agtgcacaa  gaccaggga  gcggctgct  1080
ctctgaggg  gaggaagcc  agagtatct  ctcttagat  gggctgagt  cccacaccc  1140
gcacacaca  tccctgctc  ctcacctcc  acagacagc  gggaaatga  acctctggt  1200
acagagcca  tctccgggc  tctgtgggg  gcgggtggg  cactgcagt  ggggaggat  1260
tcacacccg  aggccctgg  aagccaggg  gggggaggg  ggaagctgg  tcctgtttg  1320
cttagagat  aaggccatc  gcctccctg  accttccag  gatgtagta  gcaccccca  1380
cccagggcc  aagggcctc  cctaaaatg  ctcctgcac  cttgaggct  gctttgacc  1440
cctgcactc  accaagagc  acagctccc  tgggtccca  cttctctga  aagctgggt  1500
ggagtgtat  cagctgctg  gtgtgctta  agggcctaa  ggagaccag  cagggataa  1560
ctcctatgt  atccacatc  agccattta  caaatatgg  tttagtacc  acatatgca  1620
tgtatttgg  gtccagaga  aggagggca  cggtccaag  tcacacctg  gaggcgaat  1680
cgcatgtaa  gcagcacct  gtaacctgt  cccactgtg  ctactacta  agaaaaata  1740
atgagagaa  aagaaaaaa  gcttttttt  tttttggcc  aggccctgt  cctgggacc  1800
aagcctgag  cctttcctg  agtcgggtc  ctgacctaa  cctggggca  agctaggtc  1860
tggccagtc  gcagccacc  cgtgaagca  cccctgccc  catcacccc  ggcagcctt  1920
tgccctcct  ctcggggtc  tcagctcac  ccacctcag  cgggcctgc  ccagcggtt  1980
agtacccct  gtctgaacc  taatcgtga  gcggggcag  cccctcccc  caccctgta  2040
acactcccc  gtcctccgc  ccctggact  gtttgggcg  gaagagcct  cctcatctt  2100
tcttcctac  ctcctaccc  gtggccagg  accccaggc  tcctctgag  catccacca  2160
cggtgatgg  ttgggacca  tctccccca  tcctctcca  cctagcagt  aggtccccg  2220
tctcgatac  gccccagca  ctgcactgg  cctctctga  ttcccaact  cagcccatt  2280
caagtgctg  aggcgggtc  ctaggtgct  ggacctggg  gcggggcaa  accttgggc  2340
gtgtggggt  caggctggg  ttactgggt  cacgattga  ggagtggtc  gggggttag  2400
tgtagggcc  ggctgcgtt  tgctctaag  ggcaggcgg  aggcggttt  ggggggctg  2460
ggtcagaca  ggtggggtg  cggtgggtt  ggggaagcc  cagcagccc  ccttggggt  2520
ccgcgagtg  cgagggagc  gccggggca  ggtggcgcg  ggcccgtgg  cctgcccgg  2580
acgaccccc  ccccgcagc  ccccgcagc  ccccgcccc  gcggccccg  tcgcgacgc  2640
tctcccgcg  cgccccgcc  ccgcccgca  tgcccggat  cgggtgacg  gcggccgcc  2700
tctttccgt  ccgggcagc  agcgccagt  ggagccagc  cgagcgccg  cgccatcac  2760
gccgctgcc  agtcctcca  ccgctgccc  cgccatgtg  gtcggccgc  cgccaccct  2820
accgcgctt  cctgcgccg  ccgccgccc  tggcaaccg  ccgtcggga  tgcccgggg  2880
ctcttctgc  ttccccgcg  cccggggcc  ggcccaagc  ggtgactgc  cgcgggcgg  2940
cgaggagcc  cgcgtcccg  gctggccgg  tcgggcgat  gccgcggga  ggagcggac  3000
cagtgtcct  ctgcccctc  ccgcccctg  caccgcggc  gcctgtctt  tcgggtcga  3060
ccggatcgc  tctgtgagg  cgccctcag  tgacaggcg  ggaaactga  gccgggggg  3120
cctcgctca  ggtcacgca  ctcatcggc  gcagggctg  accgagacc  gggcttaca  3180
cgggtggcc  tcctcccga  aaggaggac  ggagggacn  ggatggaca  gtggatggg  3240
ggagccctg  ctgcggggc  gggaggctg  aagccctgg  tcttaatcc  tccctgctc  3300
tcaggtctg  taccgctgc  acggccccc  ctgctgccc  ggctgggga  ggtggtccc  3360
ctgcacccc  tccaaacct  accagtaac  ggagactgc  gcagaccca  gcccaggtg  3420
atgaggtga  tgtgggggg  gtcaaaacc  gtaggaggg  ccctggggg  tggggatag  3480
tgtaggggc  cattttggt  tgggagtga  gacagttca  gcctttggg  ttgcggaca  3540
agataccat  ccccatccc  gtctccctg  cagcacgca  ttggaaggg  gctgggggt  3600
ttaatcagc  ttgctagcc  ggggtgtgc  agcctgggc  ggtgtgctc  ggtgatgga  3660
agagcgcct  aggttccat  gagggaggg  gttgctatg  catntgaga  gtcaccagc  3720
tgcccctga  gtgtgctcc  tgcatgtcc  caggtgtgc  aggcatgtt  tgtgtgtcc  3780
tggcatgtt  acctggcag  atcagggtg  atgttccat  tgtggcacg  tgggcacat  3840
tttgaggat  gccctcact  aggtgggcc  tggcacacc  ccctgcctc  tgggccctt  3900
tcccaggtg  tggacatca  gagggtgaa  gtggacaag  tcctggagc  agaccagaa  3960
ctgtcggag  tggacgacc  tgcagatgc  ctccaggcg  gggcctccc  gtttgaaac  4020
agcgcagcc  agctcaagc  caaatactg  tggaaaaac  tcaaggtaa  ggtggggac  4080
ggaaggagg  caggtgggt  aatggggta  catagtttg  cttactgat  ctcgcctct  4140
acccccaga  gatgatcat  ttgggagtg  tttgcgcca  catcctcat  atcatcata  4200
gtgagtagg  tgagaatgg  cggggccct  tccctggag  ggtttcccc  gtggattct  4260
ggttttgaa  gtcattaat  tagttttta  tcttcagcc  aaaacacat  tagctgcta  4320
tggcaattc  gattcatct  gagccaaaa  ctttgatgt  atttagcct  cattttgcc  4380
agttcttgg  agtcttgtt  acatttgga  ataggaaag  tggtgtatc  attgaggac  4440
ctttaggcc  aagagccca  tctgagaac  ctggaattg  ggagtggga  aaaggaaag  4500
accaggggc  tgagacatg  ccaggaagc  aaccacccc  ttatttgag  gcttgcggt  4560
tcagaggct  agaggatta  ggtctgtgg  ttcaaggcc  taccatgga  cggaaggga  4620
ctcagaacc  acctgtcta  ccccttgct  tgtagatgg  aaaactgag  ccaagagag  4680
gtgtcagcc  gctggggag  ggggaggat  ggagcaggg  caggcctga  acactgctt  4740
cttgttctc  ctctttctc  cccctctcc  tcttcctca  cttcttccc  tctctccac  4800
gtttacttc  gctcttaaa  ccccgagga  tctgccctg  ctagagaag  gcctctccc  4860
caaccctca  ccgttcctc  acctctcag  catatcttt  agccccccc  cccctggat  4920
cgtgtgtgt  tgtgtccgt  tgtgtgtcc  cctgtaaat  gccagctgt  atttataca  4980
atataatat  atatatatt  ggtctgttt  tagttttat  actagatga  ttttccggt  5040
gtccttaac  ccccttcct  aggttccct  cacccctct  tcttgcctt  cttcccttt  5100
cctttcttc  tgactagcc  caagtccct  catttgcat  tgctatgca  tagtccctc  5160
cctttcctt  ttcttccct  agatttagc  gatccttcc  cccaccctg  ccttccttt  5220
ctctttcct  ctcactctc  ccgtcatgc  ccctctgcc  cgccctcaa  aaaaaaaaa  5280
aaaaaaaaa  aaaaaaaaa  caccagcac  tgtccaggc  tccttaggt  catcttctt  5340
gtatccatt  ggaggctct  agactggcc  cacttggtc  taaaaatcc  aaggtcttt  5400
ggagcgtcc  gcatgttaa  tagcgtatc  ttacatact  ctatccctt  ccatttctt  5460
ttgttccat  actcttctc  caacctgtg  ttctttttt  actgaggag  tagtcccca  5520
tagttcttg  atcacattt  catttgcac  acattactc  caggtggtg  ggagcctgg  5580
cttttgggg  accaggctg  tctggtccc  agcattgcc  cctcctagc  cctctagtc  5640
agtttgcct  ccttaccct  attttccaa  cctcttgta  cctcctctc  ctcccccag  5700
ggtatgtaa  tgtcttgaa  ttcagtatg  tatgatgga  caataattc  gcccttcgg  5760
tttctccct  cattcctgc  ccccagttt  catgtgggg  actcaactg  cattcccat  5820
gggtttccc  cccatctgc  tgatccacc  cctcctccc  ccacaagat  aattgttgg  5880
cacaattga  ctcttgtag  ggggtggct  ccagtgtgt  tgtgggggt  atcactgcc  5940
tggggagga  tggggcagg  cagagaatc  ccccaattc  tgcctgaaa  ctctggcct  6000
acccctgct  ggggttgga  tgaaaaccc  cctccccaa  ttggggggt  ttgccccat  6060
actgcccag  tcctctgac  gccccccct  aatttaggg  gggggtact  gtcactgcc  6120
atgtgtgta  gggacttgc  ggaaaacgg  gatgcttgc  cctctccag  actattgag  6180
ccagagaga  ctgtcctct  attgggtga  ctgattgag  aagggtcta  tgtcttttt  6240
aatggcaca  ttttaaggg  ttgagggta  agtccctta  cctgccacg  gagggggcc  6300
ccaaacttt  ttccccccc  cacttctgg  tttctgtgt  gagggggag  agggatatc  6360
aagctgtgg  gtgaaaggg  aggagagat  ctggaggtg  gggtgctgt  ttctagacc  6420
cccatatta  cccagtgtc  cctgccccc  tcttccccc  ccccatgcc  ccaattctg  6480
ggcgcatcc  gattgtgaa  atgtacaat  aatgtgtaa  gagtaacca  gtgttgtct  6540
agatctttt  tatttttct  ttttttttt  ttggttggg  gagaataag  tcttttctt  6600
accaatggg  ataatattg  atcggaagg  ataccagga  ggttgagaa  atacattgg  6660
aatggactg  actttgcaa  aggccctga  cttgggcag  gcaaagtgt  attctcaaa  6720
tggccacag  ggggcacta  gagttggta  tgggaagtg  catagccag  ccgtgtctc  6780
aagcccggt  cgccctatg  tctagggtt  ccagctttc  tttcccttt  ctggggcat  6840
ttcctgctg  tggactcct  tctactcct  gatttaact  ctaga  6885



<210> 3476
<211> 115
<212> PRT
<213> Homo sapiens
<308> P19065
<400> 3476

Ser Ala Thr Ala Ala Thr Ala Pro Pro Ala Ala Pro Ala Gly Glu Gly 
  1               5                  10                  15
Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln 
             20                  25                  30
Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
         35                  40                  45
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
     50                  55                  60
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
 65                  70                  75                  80
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile 
                 85                  90                  95
Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr 
             100                105                110
Phe Ser Ser 
         115



<210> 3477
<211> 912
<212> DNA
<213> Rattus norvegicus
<308> M24542
<400> 3477

tcccgcggg  tggcgggag  gctgcggcc  ctgctgcaa  gcgcggtgc  cgccacctc  60
gaaccaccg  ttctggacg  gaagcgacc  ttcctgtgc  gtgagtcgc  gagtggcca  120
gccgcgacc  gtcctttgg  ggccacagt  ggcctgaat  ttcctgctt  tgttcgtta  180
tcccacaca  acatcaagg  gcccgactt  tctgactat  gccgtgctg  agttctaga  240
agcacaaag  cttctaaag  gagcagtga  gctagaaaa  gcttctctt  cttggtaac  300
gcaactact  ctgtgggtg  tgcatacgc  gcgaaaaat  cagtctccc  gtttgtttc  360
agcatgagt  cttctgcgg  tgtactggc  atgtcgaag  tcgagatca  gttgtctga  420
attccagag  ggaagaaca  ggcttttaa  tggagaggc  aacctctgt  tgtgcgcca  480
agaaccaag  aggagattg  ccaggaagc  gcagttgaa  tgtcccagt  aagggaccc  540
cagcatgat  tagagcgtg  aaagaagcc  gaatgggtt  ttctgatcg  tgtctgtac  600
catcttggt  gtgtaccca  tgcaaacgc  ggagatttt  gtggctact  ttgcccctg  660
catgggtca  actatgatg  ttctggcag  atcaggaag  gccctgcac  tctcaacct  720
gaagtacct  cctatgagt  caccagtgg  gatgtagtt  ttgtgggtt  gacacttgg  780
ctgagggcc  aggtttctt  cggtcttca  gtcccctca  aagagttga  agtaagcct  840
gtacttcta  gttggttga  ttaaaatat  taagaattg  taataacta  tggcaaaca  900
taatgtgaa  ta  912



<210> 3478
<211> 256
<212> PRT
<213> Rattus norvegicus
<308> AAA42051
<400> 3478

Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Leu Gln Ser Ala Val 
  1               5                  10                  15
Pro Ala Thr Ser Glu Pro Pro Val Leu Asp Val Lys Arg Pro Phe Leu 
             20                  25                  30
Cys Arg Glu Ser Leu Ser Gly Gln Ala Ala Thr Arg Pro Leu Val Ala 
         35                  40                  45
Thr Val Gly Leu Asn Val Pro Ala Ser Val Arg Tyr Ser His Thr Asp 
     50                  55                  60
Ile Lys Val Pro Asp Phe Ser Asp Tyr Arg Arg Ala Glu Val Leu Asp 
 65                  70                  75                  80
Ser Thr Lys Ser Ser Lys Glu Ser Ser Glu Ala Arg Lys Gly Phe Ser 
                 85                  90                  95
Tyr Leu Val Thr Ala Thr Thr Thr Val Gly Val Ala Tyr Ala Ala Lys 
             100                105                110
Asn Ala Val Ser Gln Phe Val Ser Ser Met Ser Ala Ser Ala Asp Val 
         115                120                125
Leu Ala Met Ser Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro Glu Gly 
     130                135                140
Lys Asn Met Ala Phe Lys Trp Arg Gly Lys Pro Leu Phe Val Arg His 
 145                150                155                160
Arg Thr Lys Lys Glu Ile Asp Gln Glu Ala Ala Val Glu Val Ser Gln 
                 165                170                175
Leu Arg Asp Pro Gln His Asp Leu Glu Arg Val Lys Lys Pro Glu Trp 
             180                185                190
Val Ile Leu Ile Gly Val Cys Thr His Leu Gly Cys Val Pro Ile Ala 
         195                200                205
Asn Ala Gly Asp Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly Ser His 
     210                215                220
Tyr Asp Ala Ser Gly Arg Ile Arg Lys Gly Pro Ala Pro Leu Asn Leu 
 225                230                235                240
Glu Val Pro Thr Tyr Glu Phe Thr Ser Gly Asp Val Val Val Val Gly 
                 245                250                255



<210> 3479
<211> 1203
<212> DNA
<213> Homo sapiens
<308> NM_006003
<400> 3479

gtcgtcacg  gtcccgcgc  tcctcgcgc  tgcaccgtg  ttggaaggt  gtcccctgt  60
accggttgg  cggttggag  ggctgtcgc  atgttgtcg  tagcagccc  ctcgggccc  120
ttcgcgccc  tcctgtcgg  cacgtcccg  ggggtggcg  gcgcgctgc  gcccttggt  180
caggccacg  tgcccgcca  cccggagca  cctgtgttg  acctgaagc  gcccttcct  240
agccgggag  cgctgagcg  ccaggccgt  cgccggcct  tggtcgcct  cgtgggcct  300
aatgtccct  cttctgttt  ttattccca  acagacatc  aggtgcctg  cttctctga  360
taccgccgc  ttgaagttt  agatagtac  aagtcttca  gagaaagca  cgaggctag  420
aaaggtttc  cctatttgg  aactggagt  actactgtg  gtgtcgcat  tgctgccaa  480
aatgccgtc  cccagttcg  ttccagcat  agtgcttct  ctgatgtgt  ggccctggc  540
aaaatcgaa  tcaagttat  cgatattcc  gaaggcaag  acatggctt  caaatggag  600
ggcaaaccc  tgtttgtgc  tcatagaac  cagaaggaa  ttgagcagg  agctgcagt  660
gaattatca  agttgaggg  cccacagca  gatctagat  gagtaaaga  acctgaatg  720
gttatcctg  taggtgttt  cactcatct  ggctgtgta  ccattgcaa  tgcaggaga  780
tttggtggt  attactgcc  ttgccatgg  tcacactat  atgcatctg  caggatcag  840
ttgggtcct  ctcctctca  ccttgaagt  cccacgtat  agttcacca  tgacgatat  900
gtgattgtt  gttaagaga  ttggactca  gtcataggc  tctttcagt  tttatgtca  960
ctcaggaga  ttatttgag  ggaagcctt  tgtacttga  gttgatttg  aatatgtaa  1020
aattgatga  gtatttgca  acattaatg  gaaataaat  gaatttaat  ttgaatact  1080
tcaggcatt  acttaataa  gacactgtt  agcactgtt  tgctcagtc  tacacgcga  1140
aggtacaat  tcttttagc  aattctaat  aaaaattac  gactggtgt  caagatact  1200
gtg  1203



<210> 3480
<211> 274
<212> PRT
<213> Homo sapiens
<308> NP_005994
<400> 3480

Met Leu Ser Val Ala Ala Arg Ser Gly Pro Phe Ala Pro Val Leu Ser 
  1               5                  10                  15
Ala Thr Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Val Gln Ala 
             20                  25                  30
Thr Val Pro Ala Thr Pro Glu Gln Pro Val Leu Asp Leu Lys Arg Pro 
         35                  40                  45
Phe Leu Ser Arg Glu Ser Leu Ser Gly Gln Ala Val Arg Arg Pro Leu 
     50                  55                  60
Val Ala Ser Val Gly Leu Asn Val Pro Ala Ser Val Cys Tyr Ser His 
 65                  70                  75                  80
Thr Asp Ile Lys Val Pro Asp Phe Ser Glu Tyr Arg Arg Leu Glu Val 
                 85                  90                  95
Leu Asp Ser Thr Lys Ser Ser Arg Glu Ser Ser Glu Ala Arg Lys Gly 
             100                105                110
Phe Ser Tyr Leu Val Thr Gly Val Thr Thr Val Gly Val Ala Tyr Ala 
         115                120                125
Ala Lys Asn Ala Val Thr Gln Phe Val Ser Ser Met Ser Ala Ser Ala 
     130                135                140
Asp Val Leu Ala Leu Ala Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro 
 145                150                155                160
Glu Gly Lys Asn Met Ala Phe Lys Trp Arg Gly Lys Pro Leu Phe Val 
                 165                170                175
Arg His Arg Thr Gln Lys Glu Ile Glu Gln Glu Ala Ala Val Glu Leu 
             180                185                190
Ser Gln Leu Arg Asp Pro Gln His Asp Leu Asp Arg Val Lys Lys Pro 
         195                200                205
Glu Trp Val Ile Leu Ile Gly Val Cys Thr His Leu Gly Cys Val Pro 
     210                215                220
Ile Ala Asn Ala Gly Asp Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly 
 225                230                235                240
Ser His Tyr Asp Ala Ser Gly Arg Ile Arg Leu Gly Pro Ala Pro Leu 
                 245                250                255
Asn Leu Glu Val Pro Thr Tyr Glu Phe Thr Ser Asp Asp Met Val Ile 
             260                265                270
Val Gly 
         275



<210> 3481
<211> 912
<212> DNA
<213> Rattus norvegicus
<308> M24542
<400> 3481

tcccgcggg  tggcgggag  gctgcggcc  ctgctgcaa  gcgcggtgc  cgccacctc  60
gaaccaccg  ttctggacg  gaagcgacc  ttcctgtgc  gtgagtcgc  gagtggcca  120
gccgcgacc  gtcctttgg  ggccacagt  ggcctgaat  ttcctgctt  tgttcgtta  180
tcccacaca  acatcaagg  gcccgactt  tctgactat  gccgtgctg  agttctaga  240
agcacaaag  cttctaaag  gagcagtga  gctagaaaa  gcttctctt  cttggtaac  300
gcaactact  ctgtgggtg  tgcatacgc  gcgaaaaat  cagtctccc  gtttgtttc  360
agcatgagt  cttctgcgg  tgtactggc  atgtcgaag  tcgagatca  gttgtctga  420
attccagag  ggaagaaca  ggcttttaa  tggagaggc  aacctctgt  tgtgcgcca  480
agaaccaag  aggagattg  ccaggaagc  gcagttgaa  tgtcccagt  aagggaccc  540
cagcatgat  tagagcgtg  aaagaagcc  gaatgggtt  ttctgatcg  tgtctgtac  600
catcttggt  gtgtaccca  tgcaaacgc  ggagatttt  gtggctact  ttgcccctg  660
catgggtca  actatgatg  ttctggcag  atcaggaag  gccctgcac  tctcaacct  720
gaagtacct  cctatgagt  caccagtgg  gatgtagtt  ttgtgggtt  gacacttgg  780
ctgagggcc  aggtttctt  cggtcttca  gtcccctca  aagagttga  agtaagcct  840
gtacttcta  gttggttga  ttaaaatat  taagaattg  taataacta  tggcaaaca  900
taatgtgaa  ta  912



<210> 3482
<211> 256
<212> PRT
<213> Rattus norvegicus
<308> AAA42051
<400> 3482

Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Leu Gln Ser Ala Val 
  1               5                  10                  15
Pro Ala Thr Ser Glu Pro Pro Val Leu Asp Val Lys Arg Pro Phe Leu 
             20                  25                  30
Cys Arg Glu Ser Leu Ser Gly Gln Ala Ala Thr Arg Pro Leu Val Ala 
         35                  40                  45
Thr Val Gly Leu Asn Val Pro Ala Ser Val Arg Tyr Ser His Thr Asp 
     50                  55                  60
Ile Lys Val Pro Asp Phe Ser Asp Tyr Arg Arg Ala Glu Val Leu Asp 
 65                  70                  75                  80
Ser Thr Lys Ser Ser Lys Glu Ser Ser Glu Ala Arg Lys Gly Phe Ser 
                 85                  90                  95
Tyr Leu Val Thr Ala Thr Thr Thr Val Gly Val Ala Tyr Ala Ala Lys 
             100                105                110
Asn Ala Val Ser Gln Phe Val Ser Ser Met Ser Ala Ser Ala Asp Val 
         115                120                125
Leu Ala Met Ser Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro Glu Gly 
     130                135                140
Lys Asn Met Ala Phe Lys Trp Arg Gly Lys Pro Leu Phe Val Arg His 
 145                150                155                160
Arg Thr Lys Lys Glu Ile Asp Gln Glu Ala Ala Val Glu Val Ser Gln 
                 165                170                175
Leu Arg Asp Pro Gln His Asp Leu Glu Arg Val Lys Lys Pro Glu Trp 
             180                185                190
Val Ile Leu Ile Gly Val Cys Thr His Leu Gly Cys Val Pro Ile Ala 
         195                200                205
Asn Ala Gly Asp Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly Ser His 
     210                215                220
Tyr Asp Ala Ser Gly Arg Ile Arg Lys Gly Pro Ala Pro Leu Asn Leu 
 225                230                235                240
Glu Val Pro Thr Tyr Glu Phe Thr Ser Gly Asp Val Val Val Val Gly 
                 245                250                255



<210> 3483
<211> 1203
<212> DNA
<213> Homo sapiens
<308> NM_006003
<400> 3483

gtcgtcacg  gtcccgcgc  tcctcgcgc  tgcaccgtg  ttggaaggt  gtcccctgt  60
accggttgg  cggttggag  ggctgtcgc  atgttgtcg  tagcagccc  ctcgggccc  120
ttcgcgccc  tcctgtcgg  cacgtcccg  ggggtggcg  gcgcgctgc  gcccttggt  180
caggccacg  tgcccgcca  cccggagca  cctgtgttg  acctgaagc  gcccttcct  240
agccgggag  cgctgagcg  ccaggccgt  cgccggcct  tggtcgcct  cgtgggcct  300
aatgtccct  cttctgttt  ttattccca  acagacatc  aggtgcctg  cttctctga  360
taccgccgc  ttgaagttt  agatagtac  aagtcttca  gagaaagca  cgaggctag  420
aaaggtttc  cctatttgg  aactggagt  actactgtg  gtgtcgcat  tgctgccaa  480
aatgccgtc  cccagttcg  ttccagcat  agtgcttct  ctgatgtgt  ggccctggc  540
aaaatcgaa  tcaagttat  cgatattcc  gaaggcaag  acatggctt  caaatggag  600
ggcaaaccc  tgtttgtgc  tcatagaac  cagaaggaa  ttgagcagg  agctgcagt  660
gaattatca  agttgaggg  cccacagca  gatctagat  gagtaaaga  acctgaatg  720
gttatcctg  taggtgttt  cactcatct  ggctgtgta  ccattgcaa  tgcaggaga  780
tttggtggt  attactgcc  ttgccatgg  tcacactat  atgcatctg  caggatcag  840
ttgggtcct  ctcctctca  ccttgaagt  cccacgtat  agttcacca  tgacgatat  900
gtgattgtt  gttaagaga  ttggactca  gtcataggc  tctttcagt  tttatgtca  960
ctcaggaga  ttatttgag  ggaagcctt  tgtacttga  gttgatttg  aatatgtaa  1020
aattgatga  gtatttgca  acattaatg  gaaataaat  gaatttaat  ttgaatact  1080
tcaggcatt  acttaataa  gacactgtt  agcactgtt  tgctcagtc  tacacgcga  1140
aggtacaat  tcttttagc  aattctaat  aaaaattac  gactggtgt  caagatact  1200
gtg  1203



<210> 3484
<211> 274
<212> PRT
<213> Homo sapiens
<308> NP_005994
<400> 3484

Met Leu Ser Val Ala Ala Arg Ser Gly Pro Phe Ala Pro Val Leu Ser 
  1               5                  10                  15
Ala Thr Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Val Gln Ala 
             20                  25                  30
Thr Val Pro Ala Thr Pro Glu Gln Pro Val Leu Asp Leu Lys Arg Pro 
         35                  40                  45
Phe Leu Ser Arg Glu Ser Leu Ser Gly Gln Ala Val Arg Arg Pro Leu 
     50                  55                  60
Val Ala Ser Val Gly Leu Asn Val Pro Ala Ser Val Cys Tyr Ser His 
 65                  70                  75                  80
Thr Asp Ile Lys Val Pro Asp Phe Ser Glu Tyr Arg Arg Leu Glu Val 
                 85                  90                  95
Leu Asp Ser Thr Lys Ser Ser Arg Glu Ser Ser Glu Ala Arg Lys Gly 
             100                105                110
Phe Ser Tyr Leu Val Thr Gly Val Thr Thr Val Gly Val Ala Tyr Ala 
         115                120                125
Ala Lys Asn Ala Val Thr Gln Phe Val Ser Ser Met Ser Ala Ser Ala 
     130                135                140
Asp Val Leu Ala Leu Ala Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro 
 145                150                155                160
Glu Gly Lys Asn Met Ala Phe Lys Trp Arg Gly Lys Pro Leu Phe Val 
                 165                170                175
Arg His Arg Thr Gln Lys Glu Ile Glu Gln Glu Ala Ala Val Glu Leu 
             180                185                190
Ser Gln Leu Arg Asp Pro Gln His Asp Leu Asp Arg Val Lys Lys Pro 
         195                200                205
Glu Trp Val Ile Leu Ile Gly Val Cys Thr His Leu Gly Cys Val Pro 
     210                215                220
Ile Ala Asn Ala Gly Asp Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly 
 225                230                235                240
Ser His Tyr Asp Ala Ser Gly Arg Ile Arg Leu Gly Pro Ala Pro Leu 
                 245                250                255
Asn Leu Glu Val Pro Thr Tyr Glu Phe Thr Ser Asp Asp Met Val Ile 
             260                265                270
Val Gly 
         275



<210> 3485
<211> 912
<212> DNA
<213> Rattus norvegicus
<308> M24542
<400> 3485

tcccgcggg  tggcgggag  gctgcggcc  ctgctgcaa  gcgcggtgc  cgccacctc  60
gaaccaccg  ttctggacg  gaagcgacc  ttcctgtgc  gtgagtcgc  gagtggcca  120
gccgcgacc  gtcctttgg  ggccacagt  ggcctgaat  ttcctgctt  tgttcgtta  180
tcccacaca  acatcaagg  gcccgactt  tctgactat  gccgtgctg  agttctaga  240
agcacaaag  cttctaaag  gagcagtga  gctagaaaa  gcttctctt  cttggtaac  300
gcaactact  ctgtgggtg  tgcatacgc  gcgaaaaat  cagtctccc  gtttgtttc  360
agcatgagt  cttctgcgg  tgtactggc  atgtcgaag  tcgagatca  gttgtctga  420
attccagag  ggaagaaca  ggcttttaa  tggagaggc  aacctctgt  tgtgcgcca  480
agaaccaag  aggagattg  ccaggaagc  gcagttgaa  tgtcccagt  aagggaccc  540
cagcatgat  tagagcgtg  aaagaagcc  gaatgggtt  ttctgatcg  tgtctgtac  600
catcttggt  gtgtaccca  tgcaaacgc  ggagatttt  gtggctact  ttgcccctg  660
catgggtca  actatgatg  ttctggcag  atcaggaag  gccctgcac  tctcaacct  720
gaagtacct  cctatgagt  caccagtgg  gatgtagtt  ttgtgggtt  gacacttgg  780
ctgagggcc  aggtttctt  cggtcttca  gtcccctca  aagagttga  agtaagcct  840
gtacttcta  gttggttga  ttaaaatat  taagaattg  taataacta  tggcaaaca  900
taatgtgaa  ta  912



<210> 3486
<211> 256
<212> PRT
<213> Rattus norvegicus
<308> AAA42051
<400> 3486

Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Leu Gln Ser Ala Val 
  1               5                  10                  15
Pro Ala Thr Ser Glu Pro Pro Val Leu Asp Val Lys Arg Pro Phe Leu 
             20                  25                  30
Cys Arg Glu Ser Leu Ser Gly Gln Ala Ala Thr Arg Pro Leu Val Ala 
         35                  40                  45
Thr Val Gly Leu Asn Val Pro Ala Ser Val Arg Tyr Ser His Thr Asp 
     50                  55                  60
Ile Lys Val Pro Asp Phe Ser Asp Tyr Arg Arg Ala Glu Val Leu Asp 
 65                  70                  75                  80
Ser Thr Lys Ser Ser Lys Glu Ser Ser Glu Ala Arg Lys Gly Phe Ser 
                 85                  90                  95
Tyr Leu Val Thr Ala Thr Thr Thr Val Gly Val Ala Tyr Ala Ala Lys 
             100                105                110
Asn Ala Val Ser Gln Phe Val Ser Ser Met Ser Ala Ser Ala Asp Val 
         115                120                125
Leu Ala Met Ser Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro Glu Gly 
     130                135                140
Lys Asn Met Ala Phe Lys Trp Arg Gly Lys Pro Leu Phe Val Arg His 
 145                150                155                160
Arg Thr Lys Lys Glu Ile Asp Gln Glu Ala Ala Val Glu Val Ser Gln 
                 165                170                175
Leu Arg Asp Pro Gln His Asp Leu Glu Arg Val Lys Lys Pro Glu Trp 
             180                185                190
Val Ile Leu Ile Gly Val Cys Thr His Leu Gly Cys Val Pro Ile Ala 
         195                200                205
Asn Ala Gly Asp Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly Ser His 
     210                215                220
Tyr Asp Ala Ser Gly Arg Ile Arg Lys Gly Pro Ala Pro Leu Asn Leu 
 225                230                235                240
Glu Val Pro Thr Tyr Glu Phe Thr Ser Gly Asp Val Val Val Val Gly 
                 245                250                255



<210> 3487
<211> 1203
<212> DNA
<213> Homo sapiens
<308> NM_006003
<400> 3487

gtcgtcacg  gtcccgcgc  tcctcgcgc  tgcaccgtg  ttggaaggt  gtcccctgt  60
accggttgg  cggttggag  ggctgtcgc  atgttgtcg  tagcagccc  ctcgggccc  120
ttcgcgccc  tcctgtcgg  cacgtcccg  ggggtggcg  gcgcgctgc  gcccttggt  180
caggccacg  tgcccgcca  cccggagca  cctgtgttg  acctgaagc  gcccttcct  240
agccgggag  cgctgagcg  ccaggccgt  cgccggcct  tggtcgcct  cgtgggcct  300
aatgtccct  cttctgttt  ttattccca  acagacatc  aggtgcctg  cttctctga  360
taccgccgc  ttgaagttt  agatagtac  aagtcttca  gagaaagca  cgaggctag  420
aaaggtttc  cctatttgg  aactggagt  actactgtg  gtgtcgcat  tgctgccaa  480
aatgccgtc  cccagttcg  ttccagcat  agtgcttct  ctgatgtgt  ggccctggc  540
aaaatcgaa  tcaagttat  cgatattcc  gaaggcaag  acatggctt  caaatggag  600
ggcaaaccc  tgtttgtgc  tcatagaac  cagaaggaa  ttgagcagg  agctgcagt  660
gaattatca  agttgaggg  cccacagca  gatctagat  gagtaaaga  acctgaatg  720
gttatcctg  taggtgttt  cactcatct  ggctgtgta  ccattgcaa  tgcaggaga  780
tttggtggt  attactgcc  ttgccatgg  tcacactat  atgcatctg  caggatcag  840
ttgggtcct  ctcctctca  ccttgaagt  cccacgtat  agttcacca  tgacgatat  900
gtgattgtt  gttaagaga  ttggactca  gtcataggc  tctttcagt  tttatgtca  960
ctcaggaga  ttatttgag  ggaagcctt  tgtacttga  gttgatttg  aatatgtaa  1020
aattgatga  gtatttgca  acattaatg  gaaataaat  gaatttaat  ttgaatact  1080
tcaggcatt  acttaataa  gacactgtt  agcactgtt  tgctcagtc  tacacgcga  1140
aggtacaat  tcttttagc  aattctaat  aaaaattac  gactggtgt  caagatact  1200
gtg  1203



<210> 3488
<211> 274
<212> PRT
<213> Homo sapiens
<308> NP_005994
<400> 3488

Met Leu Ser Val Ala Ala Arg Ser Gly Pro Phe Ala Pro Val Leu Ser 
  1               5                  10                  15
Ala Thr Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Val Gln Ala 
             20                  25                  30
Thr Val Pro Ala Thr Pro Glu Gln Pro Val Leu Asp Leu Lys Arg Pro 
         35                  40                  45
Phe Leu Ser Arg Glu Ser Leu Ser Gly Gln Ala Val Arg Arg Pro Leu 
     50                  55                  60
Val Ala Ser Val Gly Leu Asn Val Pro Ala Ser Val Cys Tyr Ser His 
 65                  70                  75                  80
Thr Asp Ile Lys Val Pro Asp Phe Ser Glu Tyr Arg Arg Leu Glu Val 
                 85                  90                  95
Leu Asp Ser Thr Lys Ser Ser Arg Glu Ser Ser Glu Ala Arg Lys Gly 
             100                105                110
Phe Ser Tyr Leu Val Thr Gly Val Thr Thr Val Gly Val Ala Tyr Ala 
         115                120                125
Ala Lys Asn Ala Val Thr Gln Phe Val Ser Ser Met Ser Ala Ser Ala 
     130                135                140
Asp Val Leu Ala Leu Ala Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro 
 145                150                155                160
Glu Gly Lys Asn Met Ala Phe Lys Trp Arg Gly Lys Pro Leu Phe Val 
                 165                170                175
Arg His Arg Thr Gln Lys Glu Ile Glu Gln Glu Ala Ala Val Glu Leu 
             180                185                190
Ser Gln Leu Arg Asp Pro Gln His Asp Leu Asp Arg Val Lys Lys Pro 
         195                200                205
Glu Trp Val Ile Leu Ile Gly Val Cys Thr His Leu Gly Cys Val Pro 
     210                215                220
Ile Ala Asn Ala Gly Asp Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly 
 225                230                235                240
Ser His Tyr Asp Ala Ser Gly Arg Ile Arg Leu Gly Pro Ala Pro Leu 
                 245                250                255
Asn Leu Glu Val Pro Thr Tyr Glu Phe Thr Ser Asp Asp Met Val Ile 
             260                265                270
Val Gly 
         275



<210> 3489
<211> 912
<212> DNA
<213> Rattus norvegicus
<308> M24542
<400> 3489

tcccgcggg  tggcgggag  gctgcggcc  ctgctgcaa  gcgcggtgc  cgccacctc  60
gaaccaccg  ttctggacg  gaagcgacc  ttcctgtgc  gtgagtcgc  gagtggcca  120
gccgcgacc  gtcctttgg  ggccacagt  ggcctgaat  ttcctgctt  tgttcgtta  180
tcccacaca  acatcaagg  gcccgactt  tctgactat  gccgtgctg  agttctaga  240
agcacaaag  cttctaaag  gagcagtga  gctagaaaa  gcttctctt  cttggtaac  300
gcaactact  ctgtgggtg  tgcatacgc  gcgaaaaat  cagtctccc  gtttgtttc  360
agcatgagt  cttctgcgg  tgtactggc  atgtcgaag  tcgagatca  gttgtctga  420
attccagag  ggaagaaca  ggcttttaa  tggagaggc  aacctctgt  tgtgcgcca  480
agaaccaag  aggagattg  ccaggaagc  gcagttgaa  tgtcccagt  aagggaccc  540
cagcatgat  tagagcgtg  aaagaagcc  gaatgggtt  ttctgatcg  tgtctgtac  600
catcttggt  gtgtaccca  tgcaaacgc  ggagatttt  gtggctact  ttgcccctg  660
catgggtca  actatgatg  ttctggcag  atcaggaag  gccctgcac  tctcaacct  720
gaagtacct  cctatgagt  caccagtgg  gatgtagtt  ttgtgggtt  gacacttgg  780
ctgagggcc  aggtttctt  cggtcttca  gtcccctca  aagagttga  agtaagcct  840
gtacttcta  gttggttga  ttaaaatat  taagaattg  taataacta  tggcaaaca  900
taatgtgaa  ta  912



<210> 3490
<211> 256
<212> PRT
<213> Rattus norvegicus
<308> AAA42051
<400> 3490

Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Leu Gln Ser Ala Val 
  1               5                  10                  15
Pro Ala Thr Ser Glu Pro Pro Val Leu Asp Val Lys Arg Pro Phe Leu 
             20                  25                  30
Cys Arg Glu Ser Leu Ser Gly Gln Ala Ala Thr Arg Pro Leu Val Ala 
         35                  40                  45
Thr Val Gly Leu Asn Val Pro Ala Ser Val Arg Tyr Ser His Thr Asp 
     50                  55                  60
Ile Lys Val Pro Asp Phe Ser Asp Tyr Arg Arg Ala Glu Val Leu Asp 
 65                  70                  75                  80
Ser Thr Lys Ser Ser Lys Glu Ser Ser Glu Ala Arg Lys Gly Phe Ser 
                 85                  90                  95
Tyr Leu Val Thr Ala Thr Thr Thr Val Gly Val Ala Tyr Ala Ala Lys 
             100                105                110
Asn Ala Val Ser Gln Phe Val Ser Ser Met Ser Ala Ser Ala Asp Val 
         115                120                125
Leu Ala Met Ser Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro Glu Gly 
     130                135                140
Lys Asn Met Ala Phe Lys Trp Arg Gly Lys Pro Leu Phe Val Arg His 
 145                150                155                160
Arg Thr Lys Lys Glu Ile Asp Gln Glu Ala Ala Val Glu Val Ser Gln 
                 165                170                175
Leu Arg Asp Pro Gln His Asp Leu Glu Arg Val Lys Lys Pro Glu Trp 
             180                185                190
Val Ile Leu Ile Gly Val Cys Thr His Leu Gly Cys Val Pro Ile Ala 
         195                200                205
Asn Ala Gly Asp Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly Ser His 
     210                215                220
Tyr Asp Ala Ser Gly Arg Ile Arg Lys Gly Pro Ala Pro Leu Asn Leu 
 225                230                235                240
Glu Val Pro Thr Tyr Glu Phe Thr Ser Gly Asp Val Val Val Val Gly 
                 245                250                255



<210> 3491
<211> 1203
<212> DNA
<213> Homo sapiens
<308> NM_006003
<400> 3491

gtcgtcacg  gtcccgcgc  tcctcgcgc  tgcaccgtg  ttggaaggt  gtcccctgt  60
accggttgg  cggttggag  ggctgtcgc  atgttgtcg  tagcagccc  ctcgggccc  120
ttcgcgccc  tcctgtcgg  cacgtcccg  ggggtggcg  gcgcgctgc  gcccttggt  180
caggccacg  tgcccgcca  cccggagca  cctgtgttg  acctgaagc  gcccttcct  240
agccgggag  cgctgagcg  ccaggccgt  cgccggcct  tggtcgcct  cgtgggcct  300
aatgtccct  cttctgttt  ttattccca  acagacatc  aggtgcctg  cttctctga  360
taccgccgc  ttgaagttt  agatagtac  aagtcttca  gagaaagca  cgaggctag  420
aaaggtttc  cctatttgg  aactggagt  actactgtg  gtgtcgcat  tgctgccaa  480
aatgccgtc  cccagttcg  ttccagcat  agtgcttct  ctgatgtgt  ggccctggc  540
aaaatcgaa  tcaagttat  cgatattcc  gaaggcaag  acatggctt  caaatggag  600
ggcaaaccc  tgtttgtgc  tcatagaac  cagaaggaa  ttgagcagg  agctgcagt  660
gaattatca  agttgaggg  cccacagca  gatctagat  gagtaaaga  acctgaatg  720
gttatcctg  taggtgttt  cactcatct  ggctgtgta  ccattgcaa  tgcaggaga  780
tttggtggt  attactgcc  ttgccatgg  tcacactat  atgcatctg  caggatcag  840
ttgggtcct  ctcctctca  ccttgaagt  cccacgtat  agttcacca  tgacgatat  900
gtgattgtt  gttaagaga  ttggactca  gtcataggc  tctttcagt  tttatgtca  960
ctcaggaga  ttatttgag  ggaagcctt  tgtacttga  gttgatttg  aatatgtaa  1020
aattgatga  gtatttgca  acattaatg  gaaataaat  gaatttaat  ttgaatact  1080
tcaggcatt  acttaataa  gacactgtt  agcactgtt  tgctcagtc  tacacgcga  1140
aggtacaat  tcttttagc  aattctaat  aaaaattac  gactggtgt  caagatact  1200
gtg  1203



<210> 3492
<211> 274
<212> PRT
<213> Homo sapiens
<308> NP_005994
<400> 3492

Met Leu Ser Val Ala Ala Arg Ser Gly Pro Phe Ala Pro Val Leu Ser 
  1               5                  10                  15
Ala Thr Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Val Gln Ala 
             20                  25                  30
Thr Val Pro Ala Thr Pro Glu Gln Pro Val Leu Asp Leu Lys Arg Pro 
         35                  40                  45
Phe Leu Ser Arg Glu Ser Leu Ser Gly Gln Ala Val Arg Arg Pro Leu 
     50                  55                  60
Val Ala Ser Val Gly Leu Asn Val Pro Ala Ser Val Cys Tyr Ser His 
 65                  70                  75                  80
Thr Asp Ile Lys Val Pro Asp Phe Ser Glu Tyr Arg Arg Leu Glu Val 
                 85                  90                  95
Leu Asp Ser Thr Lys Ser Ser Arg Glu Ser Ser Glu Ala Arg Lys Gly 
             100                105                110
Phe Ser Tyr Leu Val Thr Gly Val Thr Thr Val Gly Val Ala Tyr Ala 
         115                120                125
Ala Lys Asn Ala Val Thr Gln Phe Val Ser Ser Met Ser Ala Ser Ala 
     130                135                140
Asp Val Leu Ala Leu Ala Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro 
 145                150                155                160
Glu Gly Lys Asn Met Ala Phe Lys Trp Arg Gly Lys Pro Leu Phe Val 
                 165                170                175
Arg His Arg Thr Gln Lys Glu Ile Glu Gln Glu Ala Ala Val Glu Leu 
             180                185                190
Ser Gln Leu Arg Asp Pro Gln His Asp Leu Asp Arg Val Lys Lys Pro 
         195                200                205
Glu Trp Val Ile Leu Ile Gly Val Cys Thr His Leu Gly Cys Val Pro 
     210                215                220
Ile Ala Asn Ala Gly Asp Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly 
 225                230                235                240
Ser His Tyr Asp Ala Ser Gly Arg Ile Arg Leu Gly Pro Ala Pro Leu 
                 245                250                255
Asn Leu Glu Val Pro Thr Tyr Glu Phe Thr Ser Asp Asp Met Val Ile 
             260                265                270
Val Gly 
         275



<210> 3493
<211> 912
<212> DNA
<213> Rattus norvegicus
<308> M24542
<400> 3493

tcccgcggg  tggcgggag  gctgcggcc  ctgctgcaa  gcgcggtgc  cgccacctc  60
gaaccaccg  ttctggacg  gaagcgacc  ttcctgtgc  gtgagtcgc  gagtggcca  120
gccgcgacc  gtcctttgg  ggccacagt  ggcctgaat  ttcctgctt  tgttcgtta  180
tcccacaca  acatcaagg  gcccgactt  tctgactat  gccgtgctg  agttctaga  240
agcacaaag  cttctaaag  gagcagtga  gctagaaaa  gcttctctt  cttggtaac  300
gcaactact  ctgtgggtg  tgcatacgc  gcgaaaaat  cagtctccc  gtttgtttc  360
agcatgagt  cttctgcgg  tgtactggc  atgtcgaag  tcgagatca  gttgtctga  420
attccagag  ggaagaaca  ggcttttaa  tggagaggc  aacctctgt  tgtgcgcca  480
agaaccaag  aggagattg  ccaggaagc  gcagttgaa  tgtcccagt  aagggaccc  540
cagcatgat  tagagcgtg  aaagaagcc  gaatgggtt  ttctgatcg  tgtctgtac  600
catcttggt  gtgtaccca  tgcaaacgc  ggagatttt  gtggctact  ttgcccctg  660
catgggtca  actatgatg  ttctggcag  atcaggaag  gccctgcac  tctcaacct  720
gaagtacct  cctatgagt  caccagtgg  gatgtagtt  ttgtgggtt  gacacttgg  780
ctgagggcc  aggtttctt  cggtcttca  gtcccctca  aagagttga  agtaagcct  840
gtacttcta  gttggttga  ttaaaatat  taagaattg  taataacta  tggcaaaca  900
taatgtgaa  ta  912



<210> 3494
<211> 256
<212> PRT
<213> Rattus norvegicus
<308> AAA42051
<400> 3494

Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Leu Gln Ser Ala Val 
  1               5                  10                  15
Pro Ala Thr Ser Glu Pro Pro Val Leu Asp Val Lys Arg Pro Phe Leu 
             20                  25                  30
Cys Arg Glu Ser Leu Ser Gly Gln Ala Ala Thr Arg Pro Leu Val Ala 
         35                  40                  45
Thr Val Gly Leu Asn Val Pro Ala Ser Val Arg Tyr Ser His Thr Asp 
     50                  55                  60
Ile Lys Val Pro Asp Phe Ser Asp Tyr Arg Arg Ala Glu Val Leu Asp 
 65                  70                  75                  80
Ser Thr Lys Ser Ser Lys Glu Ser Ser Glu Ala Arg Lys Gly Phe Ser 
                 85                  90                  95
Tyr Leu Val Thr Ala Thr Thr Thr Val Gly Val Ala Tyr Ala Ala Lys 
             100                105                110
Asn Ala Val Ser Gln Phe Val Ser Ser Met Ser Ala Ser Ala Asp Val 
         115                120                125
Leu Ala Met Ser Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro Glu Gly 
     130                135                140
Lys Asn Met Ala Phe Lys Trp Arg Gly Lys Pro Leu Phe Val Arg His 
 145                150                155                160
Arg Thr Lys Lys Glu Ile Asp Gln Glu Ala Ala Val Glu Val Ser Gln 
                 165                170                175
Leu Arg Asp Pro Gln His Asp Leu Glu Arg Val Lys Lys Pro Glu Trp 
             180                185                190
Val Ile Leu Ile Gly Val Cys Thr His Leu Gly Cys Val Pro Ile Ala 
         195                200                205
Asn Ala Gly Asp Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly Ser His 
     210                215                220
Tyr Asp Ala Ser Gly Arg Ile Arg Lys Gly Pro Ala Pro Leu Asn Leu 
 225                230                235                240
Glu Val Pro Thr Tyr Glu Phe Thr Ser Gly Asp Val Val Val Val Gly 
                 245                250                255



<210> 3495
<211> 1203
<212> DNA
<213> Homo sapiens
<308> NM_006003
<400> 3495

gtcgtcacg  gtcccgcgc  tcctcgcgc  tgcaccgtg  ttggaaggt  gtcccctgt  60
accggttgg  cggttggag  ggctgtcgc  atgttgtcg  tagcagccc  ctcgggccc  120
ttcgcgccc  tcctgtcgg  cacgtcccg  ggggtggcg  gcgcgctgc  gcccttggt  180
caggccacg  tgcccgcca  cccggagca  cctgtgttg  acctgaagc  gcccttcct  240
agccgggag  cgctgagcg  ccaggccgt  cgccggcct  tggtcgcct  cgtgggcct  300
aatgtccct  cttctgttt  ttattccca  acagacatc  aggtgcctg  cttctctga  360
taccgccgc  ttgaagttt  agatagtac  aagtcttca  gagaaagca  cgaggctag  420
aaaggtttc  cctatttgg  aactggagt  actactgtg  gtgtcgcat  tgctgccaa  480
aatgccgtc  cccagttcg  ttccagcat  agtgcttct  ctgatgtgt  ggccctggc  540
aaaatcgaa  tcaagttat  cgatattcc  gaaggcaag  acatggctt  caaatggag  600
ggcaaaccc  tgtttgtgc  tcatagaac  cagaaggaa  ttgagcagg  agctgcagt  660
gaattatca  agttgaggg  cccacagca  gatctagat  gagtaaaga  acctgaatg  720
gttatcctg  taggtgttt  cactcatct  ggctgtgta  ccattgcaa  tgcaggaga  780
tttggtggt  attactgcc  ttgccatgg  tcacactat  atgcatctg  caggatcag  840
ttgggtcct  ctcctctca  ccttgaagt  cccacgtat  agttcacca  tgacgatat  900
gtgattgtt  gttaagaga  ttggactca  gtcataggc  tctttcagt  tttatgtca  960
ctcaggaga  ttatttgag  ggaagcctt  tgtacttga  gttgatttg  aatatgtaa  1020
aattgatga  gtatttgca  acattaatg  gaaataaat  gaatttaat  ttgaatact  1080
tcaggcatt  acttaataa  gacactgtt  agcactgtt  tgctcagtc  tacacgcga  1140
aggtacaat  tcttttagc  aattctaat  aaaaattac  gactggtgt  caagatact  1200
gtg  1203



<210> 3496
<211> 274
<212> PRT
<213> Homo sapiens
<308> NP_005994
<400> 3496

Met Leu Ser Val Ala Ala Arg Ser Gly Pro Phe Ala Pro Val Leu Ser 
  1               5                  10                  15
Ala Thr Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Val Gln Ala 
             20                  25                  30
Thr Val Pro Ala Thr Pro Glu Gln Pro Val Leu Asp Leu Lys Arg Pro 
         35                  40                  45
Phe Leu Ser Arg Glu Ser Leu Ser Gly Gln Ala Val Arg Arg Pro Leu 
     50                  55                  60
Val Ala Ser Val Gly Leu Asn Val Pro Ala Ser Val Cys Tyr Ser His 
 65                  70                  75                  80
Thr Asp Ile Lys Val Pro Asp Phe Ser Glu Tyr Arg Arg Leu Glu Val 
                 85                  90                  95
Leu Asp Ser Thr Lys Ser Ser Arg Glu Ser Ser Glu Ala Arg Lys Gly 
             100                105                110
Phe Ser Tyr Leu Val Thr Gly Val Thr Thr Val Gly Val Ala Tyr Ala 
         115                120                125
Ala Lys Asn Ala Val Thr Gln Phe Val Ser Ser Met Ser Ala Ser Ala 
     130                135                140
Asp Val Leu Ala Leu Ala Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro 
 145                150                155                160
Glu Gly Lys Asn Met Ala Phe Lys Trp Arg Gly Lys Pro Leu Phe Val 
                 165                170                175
Arg His Arg Thr Gln Lys Glu Ile Glu Gln Glu Ala Ala Val Glu Leu 
             180                185                190
Ser Gln Leu Arg Asp Pro Gln His Asp Leu Asp Arg Val Lys Lys Pro 
         195                200                205
Glu Trp Val Ile Leu Ile Gly Val Cys Thr His Leu Gly Cys Val Pro 
     210                215                220
Ile Ala Asn Ala Gly Asp Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly 
 225                230                235                240
Ser His Tyr Asp Ala Ser Gly Arg Ile Arg Leu Gly Pro Ala Pro Leu 
                 245                250                255
Asn Leu Glu Val Pro Thr Tyr Glu Phe Thr Ser Asp Asp Met Val Ile 
             260                265                270
Val Gly 
         275



<210> 3497
<211> 912
<212> DNA
<213> Rattus norvegicus
<308> M24542
<400> 3497

tcccgcggg  tggcgggag  gctgcggcc  ctgctgcaa  gcgcggtgc  cgccacctc  60
gaaccaccg  ttctggacg  gaagcgacc  ttcctgtgc  gtgagtcgc  gagtggcca  120
gccgcgacc  gtcctttgg  ggccacagt  ggcctgaat  ttcctgctt  tgttcgtta  180
tcccacaca  acatcaagg  gcccgactt  tctgactat  gccgtgctg  agttctaga  240
agcacaaag  cttctaaag  gagcagtga  gctagaaaa  gcttctctt  cttggtaac  300
gcaactact  ctgtgggtg  tgcatacgc  gcgaaaaat  cagtctccc  gtttgtttc  360
agcatgagt  cttctgcgg  tgtactggc  atgtcgaag  tcgagatca  gttgtctga  420
attccagag  ggaagaaca  ggcttttaa  tggagaggc  aacctctgt  tgtgcgcca  480
agaaccaag  aggagattg  ccaggaagc  gcagttgaa  tgtcccagt  aagggaccc  540
cagcatgat  tagagcgtg  aaagaagcc  gaatgggtt  ttctgatcg  tgtctgtac  600
catcttggt  gtgtaccca  tgcaaacgc  ggagatttt  gtggctact  ttgcccctg  660
catgggtca  actatgatg  ttctggcag  atcaggaag  gccctgcac  tctcaacct  720
gaagtacct  cctatgagt  caccagtgg  gatgtagtt  ttgtgggtt  gacacttgg  780
ctgagggcc  aggtttctt  cggtcttca  gtcccctca  aagagttga  agtaagcct  840
gtacttcta  gttggttga  ttaaaatat  taagaattg  taataacta  tggcaaaca  900
taatgtgaa  ta  912



<210> 3498
<211> 256
<212> PRT
<213> Rattus norvegicus
<308> AAA42051
<400> 3498

Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Leu Gln Ser Ala Val 
  1               5                  10                  15
Pro Ala Thr Ser Glu Pro Pro Val Leu Asp Val Lys Arg Pro Phe Leu 
             20                  25                  30
Cys Arg Glu Ser Leu Ser Gly Gln Ala Ala Thr Arg Pro Leu Val Ala 
         35                  40                  45
Thr Val Gly Leu Asn Val Pro Ala Ser Val Arg Tyr Ser His Thr Asp 
     50                  55                  60
Ile Lys Val Pro Asp Phe Ser Asp Tyr Arg Arg Ala Glu Val Leu Asp 
 65                  70                  75                  80
Ser Thr Lys Ser Ser Lys Glu Ser Ser Glu Ala Arg Lys Gly Phe Ser 
                 85                  90                  95
Tyr Leu Val Thr Ala Thr Thr Thr Val Gly Val Ala Tyr Ala Ala Lys 
             100                105                110
Asn Ala Val Ser Gln Phe Val Ser Ser Met Ser Ala Ser Ala Asp Val 
         115                120                125
Leu Ala Met Ser Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro Glu Gly 
     130                135                140
Lys Asn Met Ala Phe Lys Trp Arg Gly Lys Pro Leu Phe Val Arg His 
 145                150                155                160
Arg Thr Lys Lys Glu Ile Asp Gln Glu Ala Ala Val Glu Val Ser Gln 
                 165                170                175
Leu Arg Asp Pro Gln His Asp Leu Glu Arg Val Lys Lys Pro Glu Trp 
             180                185                190
Val Ile Leu Ile Gly Val Cys Thr His Leu Gly Cys Val Pro Ile Ala 
         195                200                205
Asn Ala Gly Asp Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly Ser His 
     210                215                220
Tyr Asp Ala Ser Gly Arg Ile Arg Lys Gly Pro Ala Pro Leu Asn Leu 
 225                230                235                240
Glu Val Pro Thr Tyr Glu Phe Thr Ser Gly Asp Val Val Val Val Gly 
                 245                250                255



<210> 3499
<211> 1203
<212> DNA
<213> Homo sapiens
<308> NM_006003
<400> 3499

gtcgtcacg  gtcccgcgc  tcctcgcgc  tgcaccgtg  ttggaaggt  gtcccctgt  60
accggttgg  cggttggag  ggctgtcgc  atgttgtcg  tagcagccc  ctcgggccc  120
ttcgcgccc  tcctgtcgg  cacgtcccg  ggggtggcg  gcgcgctgc  gcccttggt  180
caggccacg  tgcccgcca  cccggagca  cctgtgttg  acctgaagc  gcccttcct  240
agccgggag  cgctgagcg  ccaggccgt  cgccggcct  tggtcgcct  cgtgggcct  300
aatgtccct  cttctgttt  ttattccca  acagacatc  aggtgcctg  cttctctga  360
taccgccgc  ttgaagttt  agatagtac  aagtcttca  gagaaagca  cgaggctag  420
aaaggtttc  cctatttgg  aactggagt  actactgtg  gtgtcgcat  tgctgccaa  480
aatgccgtc  cccagttcg  ttccagcat  agtgcttct  ctgatgtgt  ggccctggc  540
aaaatcgaa  tcaagttat  cgatattcc  gaaggcaag  acatggctt  caaatggag  600
ggcaaaccc  tgtttgtgc  tcatagaac  cagaaggaa  ttgagcagg  agctgcagt  660
gaattatca  agttgaggg  cccacagca  gatctagat  gagtaaaga  acctgaatg  720
gttatcctg  taggtgttt  cactcatct  ggctgtgta  ccattgcaa  tgcaggaga  780
tttggtggt  attactgcc  ttgccatgg  tcacactat  atgcatctg  caggatcag  840
ttgggtcct  ctcctctca  ccttgaagt  cccacgtat  agttcacca  tgacgatat  900
gtgattgtt  gttaagaga  ttggactca  gtcataggc  tctttcagt  tttatgtca  960
ctcaggaga  ttatttgag  ggaagcctt  tgtacttga  gttgatttg  aatatgtaa  1020
aattgatga  gtatttgca  acattaatg  gaaataaat  gaatttaat  ttgaatact  1080
tcaggcatt  acttaataa  gacactgtt  agcactgtt  tgctcagtc  tacacgcga  1140
aggtacaat  tcttttagc  aattctaat  aaaaattac  gactggtgt  caagatact  1200
gtg  1203



<210> 3500
<211> 274
<212> PRT
<213> Homo sapiens
<308> NP_005994
<400> 3500

Met Leu Ser Val Ala Ala Arg Ser Gly Pro Phe Ala Pro Val Leu Ser 
  1               5                  10                  15
Ala Thr Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Val Gln Ala 
             20                  25                  30
Thr Val Pro Ala Thr Pro Glu Gln Pro Val Leu Asp Leu Lys Arg Pro 
         35                  40                  45
Phe Leu Ser Arg Glu Ser Leu Ser Gly Gln Ala Val Arg Arg Pro Leu 
     50                  55                  60
Val Ala Ser Val Gly Leu Asn Val Pro Ala Ser Val Cys Tyr Ser His 
 65                  70                  75                  80
Thr Asp Ile Lys Val Pro Asp Phe Ser Glu Tyr Arg Arg Leu Glu Val 
                 85                  90                  95
Leu Asp Ser Thr Lys Ser Ser Arg Glu Ser Ser Glu Ala Arg Lys Gly 
             100                105                110
Phe Ser Tyr Leu Val Thr Gly Val Thr Thr Val Gly Val Ala Tyr Ala 
         115                120                125
Ala Lys Asn Ala Val Thr Gln Phe Val Ser Ser Met Ser Ala Ser Ala 
     130                135                140
Asp Val Leu Ala Leu Ala Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro 
 145                150                155                160
Glu Gly Lys Asn Met Ala Phe Lys Trp Arg Gly Lys Pro Leu Phe Val 
                 165                170                175
Arg His Arg Thr Gln Lys Glu Ile Glu Gln Glu Ala Ala Val Glu Leu 
             180                185                190
Ser Gln Leu Arg Asp Pro Gln His Asp Leu Asp Arg Val Lys Lys Pro 
         195                200                205
Glu Trp Val Ile Leu Ile Gly Val Cys Thr His Leu Gly Cys Val Pro 
     210                215                220
Ile Ala Asn Ala Gly Asp Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly 
 225                230                235                240
Ser His Tyr Asp Ala Ser Gly Arg Ile Arg Leu Gly Pro Ala Pro Leu 
                 245                250                255
Asn Leu Glu Val Pro Thr Tyr Glu Phe Thr Ser Asp Asp Met Val Ile 
             260                265                270
Val Gly 
         275



<210> 3501
<211> 1160
<212> DNA
<213> Rattus norvegicus
<308> M24604
<400> 3501

ttgtcagca  gacctcgct  cccttacag  aactctcat  tagacgtcg  aactccgcc  60
ccatgtttg  ggcacgcct  atccagggc  ccatcctga  gaaggtgct  gaggccctc  120
aagacctca  caatgaggc  tgctgggac  tcagttcgg  cggcgtgaa  ctacagagc  180
tggattcgt  tcacgtctc  ttagtgcag  ttactctgc  ctccgaagg  ttcgacaca  240
accgctgcg  tcgcaacct  gccatgggc  tgaacctca  cagcatgtc  aaaattcta  300
aatgtgctg  taatgaaga  atcattaca  taagggctg  agataatgc  gatacctta  360
cactagtat  tgaagcacc  aatcaagag  aagtttcag  ctatgagat  aagttaatg  420
acttagacg  tgagcaact  ggaatccca  aacaggagt  cagctgcgt  gtaaagatg  480
catctggtg  atttgcacg  atatgccgg  accttagcc  tattggaga  gctgtggtg  540
tctcctgtg  aaaggacgg  gtgaagttt  ctgcgagtg  ggagcttgg  aatgggaac  600
ttaagttgt  ccagacaag  aatgttgat  aagaagagg  agctgtgtc  atagagatg  660
atgagccag  tcagctaac  tttgctctg  ggtacctga  ctttttcac  aaagccact  720
cactgtctc  tacagtaac  ctcagtatg  ctgcagatg  accccttgt  gtagagtat  780
aaattgctg  catgggaca  ttaaagtat  atttggctc  caagatcga  gatgaagaa  840
gatcttagg  gttgctaga  attgagaaa  taaaccttt  acgatcgct  ctgagatgc  900
agcgtgttc  gaggtcttt  ctgtcacca  gtttgtacc  gagtattct  aaatattaa  960
ataaaatgt  gatatcttc  gtaaataac  ttttttttc  tctccataa  ttgcttaca  1020
aataagctc  aaagtaaaa  ctggttttg  taacataaa  gtctctgcc  tacaaatac  1080
ggtgatttt  ataaatgat  ttgacgcta  atgcagttt  aagaaatat  tttcaattt  1140
aataaagtt  actgaatttg  1160



<210> 3502
<211> 261
<212> PRT
<213> Rattus norvegicus
<308> CAA68261
<400> 3502

Met Phe Glu Ala Arg Leu Ile Gln Gly Ser Ile Leu Lys Lys Val Leu 
  1               5                  10                  15
Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser 
             20                  25                  30
Gly Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val 
         35                  40                  45
Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg 
     50                  55                  60
Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys 
 65                  70                  75                  80
Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala 
                 85                  90                  95
Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser 
             100                105                110
Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile 
         115                120                125
Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe 
     130                135                140
Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile 
 145                150                155                160
Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly 
                 165                170                175
Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu 
             180                185                190
Glu Ala Val Ser Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala 
         195                200                205
Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Pro Thr 
     210                215                220
Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys 
 225                230                235                240
Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu 
                 245                250                255
Asp Glu Glu Gly Ser 
             260



<210> 3503
<211> 1231
<212> DNA
<213> Homo sapiens
<308> NM_002592
<400> 3503

aggtctcag  cggtcgtcg  gacgttcgc  cgctcgctc  gaggctcct  aagccgaaa  60
tagctagac  ttcctcctt  ccgcctgcc  gtagcggcg  tgttgccac  ccgccacca  120
gttcgaggc  cgcctggtc  agggctcca  cctcaagaa  gtgttggag  cactcaagg  180
cctcatcaa  gaggcctgc  gggatatta  ctccagcgg  gtaaacctg  agagcatgg  240
ctcgtccca  gtctctttg  tgcagctca  cctgcggtc  gagggcttc  acacctacc  300
ctgcgaccg  aacctggcc  tgggcgtga  cctcaccag  atgtccaaa  tactaaaat  360
cgccggcaa  gaagatatc  ttacactaa  ggccgaaga  aacgcggat  ccttggcgc  420
agtatttga  gcaccaaac  aggagaaag  ttcagacta  gaaatgaag  tgatggatt  480
agatgttga  caacttgga  ttccagaac  ggagtacag  tgtgtagta  agatgcctt  540
tggtgaatt  gcacgtata  gccgagatc  cagccatat  ggagatgct  ttgtaattt  600
ctgtgcaaa  gacggagtg  aattttctg  aagtggaga  cttggaaat  gaaacatta  660
attgtcaca  acaagtaat  tcgataaag  ggaggaagc  gttaccata  agatgaatg  720
accagttca  ctaactttt  cactgaggt  cctgaactt  tttacaaaa  ccactccac  780
ctcttcaac  gtgacactc  gtatgtctg  agatgtacc  cttgttgta  agtataaaa  840
tgcggatat  ggacactta  aatactact  ggctcccaa  atcgaggat  aagaaggat  900
ttaggcatt  ttaaaattc  agaaaataa  actaagctc  ttgagaact  cttctaaga  960
gccagcata  actgaagtc  tttctgtca  caaatttgt  cctctaagt  catatgtag  1020
tattgtttt  tgtaaataa  ctatttttt  tctctattc  ctccaattt  tttaaagaa  1080
aaagtccaa  gtctgatct  gtctagtta  cctagaagt  tttttgtct  ttagaaata  1140
ttgtgattt  tataataca  aagggtctt  actctaaat  cagttttaa  aagtgtttt  1200
gaatttaaa  aaagttact  gaatttcaa  c  1231



<210> 3504
<211> 261
<212> PRT
<213> Homo sapiens
<308> P12004
<400> 3504

Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu 
  1               5                  10                  15
Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser 
             20                  25                  30
Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val 
         35                  40                  45
Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg 
     50                  55                  60
Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys 
 65                  70                  75                  80
Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala 
                 85                  90                  95
Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser 
             100                105                110
Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile 
         115                120                125
Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe 
     130                135                140
Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile 
 145                150                155                160
Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly 
                 165                170                175
Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu 
             180                185                190
Glu Ala Val Thr Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala 
         195                200                205
Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr 
     210                215                220
Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys 
 225                230                235                240
Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu 
                 245                250                255
Asp Glu Glu Gly Ser 
             260



<210> 3505
<211> 1160
<212> DNA
<213> Rattus norvegicus
<308> M24604
<400> 3505

ttgtcagca  gacctcgct  cccttacag  aactctcat  tagacgtcg  aactccgcc  60
ccatgtttg  ggcacgcct  atccagggc  ccatcctga  gaaggtgct  gaggccctc  120
aagacctca  caatgaggc  tgctgggac  tcagttcgg  cggcgtgaa  ctacagagc  180
tggattcgt  tcacgtctc  ttagtgcag  ttactctgc  ctccgaagg  ttcgacaca  240
accgctgcg  tcgcaacct  gccatgggc  tgaacctca  cagcatgtc  aaaattcta  300
aatgtgctg  taatgaaga  atcattaca  taagggctg  agataatgc  gatacctta  360
cactagtat  tgaagcacc  aatcaagag  aagtttcag  ctatgagat  aagttaatg  420
acttagacg  tgagcaact  ggaatccca  aacaggagt  cagctgcgt  gtaaagatg  480
catctggtg  atttgcacg  atatgccgg  accttagcc  tattggaga  gctgtggtg  540
tctcctgtg  aaaggacgg  gtgaagttt  ctgcgagtg  ggagcttgg  aatgggaac  600
ttaagttgt  ccagacaag  aatgttgat  aagaagagg  agctgtgtc  atagagatg  660
atgagccag  tcagctaac  tttgctctg  ggtacctga  ctttttcac  aaagccact  720
cactgtctc  tacagtaac  ctcagtatg  ctgcagatg  accccttgt  gtagagtat  780
aaattgctg  catgggaca  ttaaagtat  atttggctc  caagatcga  gatgaagaa  840
gatcttagg  gttgctaga  attgagaaa  taaaccttt  acgatcgct  ctgagatgc  900
agcgtgttc  gaggtcttt  ctgtcacca  gtttgtacc  gagtattct  aaatattaa  960
ataaaatgt  gatatcttc  gtaaataac  ttttttttc  tctccataa  ttgcttaca  1020
aataagctc  aaagtaaaa  ctggttttg  taacataaa  gtctctgcc  tacaaatac  1080
ggtgatttt  ataaatgat  ttgacgcta  atgcagttt  aagaaatat  tttcaattt  1140
aataaagtt  actgaatttg  1160



<210> 3506
<211> 261
<212> PRT
<213> Rattus norvegicus
<308> CAA68261
<400> 3506

Met Phe Glu Ala Arg Leu Ile Gln Gly Ser Ile Leu Lys Lys Val Leu 
  1               5                  10                  15
Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser 
             20                  25                  30
Gly Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val 
         35                  40                  45
Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg 
     50                  55                  60
Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys 
 65                  70                  75                  80
Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala 
                 85                  90                  95
Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser 
             100                105                110
Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile 
         115                120                125
Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe 
     130                135                140
Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile 
 145                150                155                160
Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly 
                 165                170                175
Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu 
             180                185                190
Glu Ala Val Ser Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala 
         195                200                205
Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Pro Thr 
     210                215                220
Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys 
 225                230                235                240
Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu 
                 245                250                255
Asp Glu Glu Gly Ser 
             260



<210> 3507
<211> 1231
<212> DNA
<213> Homo sapiens
<308> NM_002592
<400> 3507

aggtctcag  cggtcgtcg  gacgttcgc  cgctcgctc  gaggctcct  aagccgaaa  60
tagctagac  ttcctcctt  ccgcctgcc  gtagcggcg  tgttgccac  ccgccacca  120
gttcgaggc  cgcctggtc  agggctcca  cctcaagaa  gtgttggag  cactcaagg  180
cctcatcaa  gaggcctgc  gggatatta  ctccagcgg  gtaaacctg  agagcatgg  240
ctcgtccca  gtctctttg  tgcagctca  cctgcggtc  gagggcttc  acacctacc  300
ctgcgaccg  aacctggcc  tgggcgtga  cctcaccag  atgtccaaa  tactaaaat  360
cgccggcaa  gaagatatc  ttacactaa  ggccgaaga  aacgcggat  ccttggcgc  420
agtatttga  gcaccaaac  aggagaaag  ttcagacta  gaaatgaag  tgatggatt  480
agatgttga  caacttgga  ttccagaac  ggagtacag  tgtgtagta  agatgcctt  540
tggtgaatt  gcacgtata  gccgagatc  cagccatat  ggagatgct  ttgtaattt  600
ctgtgcaaa  gacggagtg  aattttctg  aagtggaga  cttggaaat  gaaacatta  660
attgtcaca  acaagtaat  tcgataaag  ggaggaagc  gttaccata  agatgaatg  720
accagttca  ctaactttt  cactgaggt  cctgaactt  tttacaaaa  ccactccac  780
ctcttcaac  gtgacactc  gtatgtctg  agatgtacc  cttgttgta  agtataaaa  840
tgcggatat  ggacactta  aatactact  ggctcccaa  atcgaggat  aagaaggat  900
ttaggcatt  ttaaaattc  agaaaataa  actaagctc  ttgagaact  cttctaaga  960
gccagcata  actgaagtc  tttctgtca  caaatttgt  cctctaagt  catatgtag  1020
tattgtttt  tgtaaataa  ctatttttt  tctctattc  ctccaattt  tttaaagaa  1080
aaagtccaa  gtctgatct  gtctagtta  cctagaagt  tttttgtct  ttagaaata  1140
ttgtgattt  tataataca  aagggtctt  actctaaat  cagttttaa  aagtgtttt  1200
gaatttaaa  aaagttact  gaatttcaa  c  1231



<210> 3508
<211> 261
<212> PRT
<213> Homo sapiens
<308> P12004
<400> 3508

Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu 
  1               5                  10                  15
Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser 
             20                  25                  30
Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val 
         35                  40                  45
Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg 
     50                  55                  60
Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys 
 65                  70                  75                  80
Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala 
                 85                  90                  95
Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser 
             100                105                110
Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile 
         115                120                125
Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe 
     130                135                140
Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile 
 145                150                155                160
Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly 
                 165                170                175
Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu 
             180                185                190
Glu Ala Val Thr Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala 
         195                200                205
Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr 
     210                215                220
Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys 
 225                230                235                240
Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu 
                 245                250                255
Asp Glu Glu Gly Ser 
             260



<210> 3509
<211> 607
<212> DNA
<213> Rattus norvegicus
<308> M25584
<400> 3509

cccaaccct  agtgaccag  tacaatcat  gaccatcag  aagcaggta  gtactctcc  60
gggtgagcc  ggttccccc  gccaaaact  tagggactt  aggaaggat  tgggttcct  120
tcttacatg  accttttcc  agcctcaac  ctgcctatc  tccaggtca  tgttccaac  180
tggccctgt  gatgcgctt  ctgcccctg  tggccctgc  cgtcctctg  gagcccaag  240
ctgcccagg  ttttgtcaa  cagcacctt  gtggtcctc  cctggtgga  gctctgtac  300
tggtgtgtg  ggaacgtgg  ttcttctac  cacccaagt  ccgtcgtga  gtggaggac  360
cgcaagtgc  acaactgga  ctgggtgga  gcccggagg  cggggatct  cagaccttg  420
cactggagg  tgcccggca  aagcgtggc  ttgtggatc  gtgctgcac  agcatctgc  480
ccctctacc  actggagaa  tactgcaac  gagtccacc  ctccccgcc  acccctctg  540
aatgaataa  gcctttgaa  gagcaccaa  atgagagag  ttttatgaa  acaaaggga  600
tgtgtga  607



<210> 3510
<211> 110
<212> PRT
<213> Rattus norvegicus
<308> CAA24559
<400> 3510

Met Ala Leu Trp Met Arg Phe Leu Pro Leu Leu Ala Leu Leu Val Leu 
  1               5                  10                  15
Trp Glu Pro Lys Pro Ala Gln Ala Phe Val Lys Gln His Leu Cys Gly 
             20                  25                  30
Pro His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
         35                  40                  45
Phe Tyr Thr Pro Lys Ser Arg Arg Glu Val Glu Asp Pro Gln Val Pro 
     50                  55                  60
Gln Leu Glu Leu Gly Gly Gly Pro Glu Ala Gly Asp Leu Gln Thr Leu 
 65                  70                  75                  80
Ala Leu Glu Val Ala Arg Gln Lys Arg Gly Ile Val Asp Gln Cys Cys 
                 85                  90                  95
Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
             100                105                110



<210> 3511
<211> 4044
<212> DNA
<213> Homo sapiens
<308> J00265
<400> 3511

ctcgagggg  ctagacatt  ccctccaga  agagcaccc  acaccctcc  ggcttgacc  60
gccagggtg  ccccttcct  ccttggaga  agcagcccc  gggcatcct  cagggggtg  120
tgggacacc  gctggcctt  aaggtctct  cctccctcc  gccacccca  tacacgctg  180
tgggatcct  gatctcagc  ccctggccg  caacactgg  aaactccta  tcatccacg  240
aggccctcc  gggcatggt  gtccttccc  gcctggcag  ctgttcctc  cacaccttg  300
tagtgccca  cccctgagg  tgcagctgg  ggtgtctct  aagggctgt  agcccccag  360
aagccctgg  gaagtgcct  ccttgcctc  ccccggccc  gccagcgcc  ggctctgcc  420
tcctacctg  gctcccccc  tccagcctc  ctccctaca  actcctctc  aggaggcac  480
catgtcctc  ccagctgcc  ggcctcaga  cactgtggc  tcctggggc  gccaccgca  540
gtcctgctg  ggcatggct  agggtggaa  gggcggaag  gaggggtcc  gcagatagc  600
ggtgcccac  accaaaccc  ctcggggca  gagagccaa  ggctgggtg  gtgcagagc  660
gccccgaga  gttccgagg  tgaggccag  gtgggacat  gggatgcga  gggccgggg  720
acaggatac  ccaacctgc  tgcccccat  gtctcatcc  cctgcttct  ggacctcct  780
atcctgccc  tggtgctaa  aggcaggta  ggggctgca  gcagcaggg  tcggagccc  840
tgccccctc  ccatgggtc  ggctggacc  ccaggtgcc  gttctgggg  gctgggagg  900
ccggagggg  gtaccccag  ggctcagcc  agatgacac  atgggggtg  tggtgtcat  960
ggacctggc  aggagaggg  agatgggct  ccagaagag  agtgggggc  gagagggtg  1020
ctggggggc  aggacggag  tgggccagt  cacagcttc  cacacctgc  cacccccag  1080
gtcctgccg  cacccccag  tcacacgga  gatgaggtc  gagtggcct  ctgaggact  1140
gctgcttgt  cccaggtcc  caggtcatg  cctccttct  ccaccctgg  gagctgagg  1200
cctcagctg  ggctgctgt  ctaaggcag  gtgggaact  ggcagccag  agggagggg  1260
cccctccct  actcccact  tcccacccc  accaccttg  cccatccat  gcggcatct  1320
gggccatcc  ggactgggg  caggggtcc  ggggacagg  gtccgggga  agggtcctg  1380
ggacagggg  gtggggaca  gggtctggg  acaggggtg  ggggacagg  gtgtgggga  1440
aggggtctg  ggacagggg  gtggggaca  gggtccggg  acaggggtg  ggggacagg  1500
gtctgggga  aggggtgtg  ggacagggg  gtggggaca  gggtctggg  acaggggtg  1560
ggggacagg  gtcctgggg  caggggtgt  gggacaggg  tgtggggac  ggggtgtgg  1620
gacaggggt  tggggacag  ggtcctggg  ataggggtg  ggggacagg  gtgtgggga  1680
aggggtccc  gggacaggg  tgtggggac  ggggtgtgg  gacaggggt  ctggggaca  1740
gggtctgag  acaggggtg  gggcacagg  gtcctgggg  caggggtcc  ggggacagg  1800
gtcctgggg  caggggtct  gggacagca  cgcaaagag  cccgccctg  agcctccag  1860
tctcctggt  taatgtgga  agtggccca  gtgagggct  tgctctcct  gagacattt  1920
cccccagct  tgagcaggg  caggtctgg  caccgggcc  ctggttaag  ctctaatga  1980
ccgctggtc  tgaggaaga  gtgctgacg  ccaaggaga  cttcccaca  acccagcac  2040
agggaaatg  tccggaaat  gcagcctca  cccccagcc  tctgccgac  cccccaccc  2100
gccctaatg  gccaggcgg  aggggttga  aggtagggg  gatgggctc  gagactata  2160
agccagcgg  ggcccagca  ccctcagcc  tccaggaca  gctgcatca  aagaggcca  2220
caagcaggt  tgttccaag  gcctttgcg  caggtgggc  cagggttcc  gggtggctg  2280
accccaggc  ccagctctg  agcagggag  acgtggctg  gctcgtgaa  catgtgggg  2340
tgagcccag  ggccccaag  cagggcacc  ggccttcag  ctgcctcag  cctgcctgt  2400
tcccagatc  ctgtccttc  gccatggcc  tgtggatgc  cctcctgcc  ctgctggcg  2460
tgctggccc  ctggggacc  gacccagcc  cagcctttg  gaaccaaca  ctgtgcggc  2520
cacacctgg  ggaagctct  tacctagtg  gcggggaac  aggcttctt  tacacaccc  2580
agacccgcc  ggaggcaga  gacctgcag  gtgagccaa  cgcccattg  tgcccctgg  2640
cgcccccag  caccccctg  tcctggcgc  cccacccag  atgggcaga  gggggcagg  2700
ggctgccac  cagcagggg  tcaggtgca  ttttttaaa  agaagttct  ttggtcacg  2760
cctaaaagt  accagctcc  tgtggccca  tcagaatct  agcctgagg  cggtgttgg  2820
ttcggcagc  ccgagatac  tcagagggt  ggcacgctc  tccctccac  cgcccctca  2880
acaaatgcc  cgcagccca  ttctccacc  tcatttgat  accgcagat  caagtgttt  2940
gttaagtaa  gtcctgggt  acctggggt  acagggtgc  ccacgctgc  tgcctctgg  3000
cgaacaccc  atcacgccc  gaggagggc  tggctgcct  cctgagtgg  ccagacccc  3060
gtcgccagc  tcacggcag  tccatagtc  ggagatggg  aagatgctg  ggacaggcc  3120
tggggagaa  tactgggat  acctgttca  gctcccact  tgacgctgc  ccggggcgg  3180
ggaaggagg  gggacatgt  ggcgttggg  cctgtaggt  cacacccag  gtgggtgac  3240
ctccctcta  cctgggtcc  gcccggctg  agatgggtg  gagtgcgac  tagggctgg  3300
gggcaggcg  gcactgtgt  tccctgact  tgtcctcct  tgtccctct  cctcgccgc  3360
gttccggaa  ctgctctgc  cggcacgtc  tggcagtgg  gcaggtgga  ctgggcggg  3420
gccctggtg  aggcagcct  cagcccttg  ccctggagg  gtccctgca  aagcgtggc  3480
ttgtggaac  atgctgtac  agcatctgc  ccctctacc  gctggagaa  tactgcaac  3540
agacgcagc  tgcaggcag  cccacaccc  ccgcctcct  caccgagag  gatggaata  3600
agcccttga  ccagccctg  tgtgccgtc  gtgtgtctt  ggggccctg  gccaagccc  3660
acttcccgg  actgttgtg  gcccctccc  gctctctcc  cgctctctg  gtgcccaca  3720
gtgccaacg  cggccaggc  cagcatgca  tggctctcc  caaagcggc  atgcctgtt  3780
gctgcctgc  gcccccacc  tgtggctca  ggtccagta  gggagcttc  ggggtctct  3840
aggggccag  gatggtggg  ccactgaga  gtgacttct  gttcagtag  tctggactc  3900
tggagtccc  agagacctt  ttcaggaaa  ggaatgaga  cattccagc  attttcccc  3960
cacctagcc  tcccaggtt  tatttttag  gttatttct  atggagtcc  tgtggaggg  4020
ggaggctgg  ctgagggag  gggt  4044



<210> 3512
<211> 110
<212> PRT
<213> Homo sapiens
<308> AAA59172
<400> 3512

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
  1               5                  10                  15
Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
             20                  25                  30
Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
         35                  40                  45
Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
     50                  55                  60
Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
 65                  70                  75                  80
Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                 85                  90                  95
Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
             100                105                110



<210> 3513
<211> 861
<212> DNA
<213> Rattus norvegicus
<308> M25638
<400> 3513

aaggcgcgg  tgagctcgc  cgcccgcgc  gagctggag  agcgcatcg  cagcctgat  60
gacgagata  ccttcctga  aaaggtgca  gaggaagag  tcgccgagc  gcaggctca  120
atccagtat  ctcagatct  cgtggagat  gacgtgtcc  ccaagcccg  cctctccgc  180
gctctcaag  acatccgcg  tcagtacga  aagctggcc  ccaagaata  gcagaatgc  240
gaagagtgg  tcaagagcc  cttcacggt  ctaaccgag  gcgccgcca  gaacaccga  300
gcagtgcgc  ctgccaagg  cgaggtgtc  gaaagccgc  gcctactca  ggctaagac  360
ctagagatc  aagcctgcc  gggtatgaa  gaagctcta  agaagcagc  gcaggagct  420
gaggacaag  agaatgcag  catcagcgc  atgcaggac  caatcaaca  actggagaa  480
gagctgcga  gcacgaaga  cgagatggc  aggtacctg  aggagtacc  ggacctcct  540
aatgtcaag  tggcattgg  cattgagat  gcagcttac  ggaaactct  ggaaggcga  600
gaaaccaag  tcagtttca  cagcgtggg  agcataacc  gcggctact  tcagagctc  660
caggtcttt  gccgttctg  ttacagtgg  ttgcagagc  gctcctact  gatgtctgc  720
cgagcattc  cagcctact  taccagcca  gtccaggag  agcagtcag  ggtggagga  780
accattgag  ctacgaaag  tgaggaggc  aaggatgag  ccccctctg  aggagaaga  840
gaagaggag  agaaggatg  a  861



<210> 3514
<211> 541
<212> PRT
<213> Rattus norvegicus
<308> AAA41694
<400> 3514

Ser Ser Phe Ser Tyr Glu Pro Tyr Phe Ser Thr Ser Tyr Lys Arg Arg 
  1               5                  10                  15
Tyr Val Glu Thr Pro Arg Val His Ile Ser Ser Val Arg Ser Gly Tyr 
             20                  25                  30
Ser Thr Ala Arg Ser Ala Tyr Ser Ser Tyr Ser Ala Pro Val Ser Ser 
         35                  40                  45
Ser Leu Ser Val Arg Arg Ser Tyr Ser Ser Ser Ser Gly Ser Leu Met 
     50                  55                  60
Pro Ser Leu Glu Asn Leu Asp Leu Ser Gln Val Ala Ala Ile Ser Asn 
 65                  70                  75                  80
Asp Leu Lys Ser Ile Arg Thr Gln Glu Lys Ala Gln Leu Gln Asp Leu 
                 85                  90                  95
Asn Asp Arg Phe Ala Ser Phe Ile Glu Arg Val His Glu Leu Glu Gln 
             100                105                110
Gln Asn Lys Val Leu Glu Ala Glu Leu Leu Val Leu Arg Gln Lys His 
         115                120                125
Ser Glu Pro Ser Arg Phe Arg Ala Leu Tyr Glu Gln Glu Ile Arg Asp 
     130                135                140
Leu Arg Leu Ala Ala Glu Asp Ala Thr Asn Glu Lys Gln Ala Leu Gln 
 145                150                155                160
Gly Glu Arg Glu Gly Leu Glu Glu Thr Leu Arg Asn Leu Gln Ala Arg 
                 165                170                175
Tyr Glu Glu Glu Val Leu Ser Arg Glu Asp Ala Glu Gly Arg Leu Met 
             180                185                190
Glu Ala Arg Lys Gly Ala Asp Glu Ala Ala Leu Ala Arg Ala Glu Leu 
         195                200                205
Glu Lys Arg Ile Asp Ser Leu Met Asp Glu Ile Ala Phe Leu Lys Lys 
     210                215                220
Val His Glu Glu Glu Ile Ala Glu Leu Gln Ala Gln Ile Gln Tyr Ala 
 225                230                235                240
Gln Ile Ser Val Glu Met Asp Val Ser Ser Lys Pro Asp Leu Ser Ala 
                 245                250                255
Ala Leu Lys Asp Ile Arg Ala Gln Tyr Glu Lys Leu Ala Ala Lys Asn 
             260                265                270
Met Gln Asn Ala Glu Glu Trp Phe Lys Ser Arg Phe Thr Val Leu Thr 
         275                280                285
Glu Ser Ala Ala Lys Asn Thr Asp Ala Val Arg Ala Ala Lys Asp Glu 
     290                295                300
Val Ser Glu Ser Arg Arg Leu Leu Lys Ala Lys Thr Leu Glu Ile Glu 
 305                310                315                320
Ala Cys Arg Gly Met Asn Glu Ala Leu Glu Lys Gln Leu Gln Glu Leu 
                 325                330                335
Glu Asp Lys Gln Asn Ala Asp Ile Ser Ala Met Gln Asp Thr Ile Asn 
             340                345                350
Lys Leu Glu Asn Glu Leu Arg Ser Thr Lys Ser Glu Met Ala Arg Tyr 
         355                360                365
Leu Lys Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile 
     370                375                380
Glu Ile Ala Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Thr Arg Leu 
 385                390                395                400
Ser Phe Thr Ser Val Gly Ser Ile Thr Ser Gly Tyr Ser Gln Ser Ser 
                 405                410                415
Gln Val Phe Gly Arg Ser Ala Tyr Ser Gly Leu Gln Ser Ser Ser Tyr 
             420                425                430
Leu Met Ser Ala Arg Ala Phe Pro Ala Tyr Tyr Thr Ser His Val Gln 
         435                440                445
Glu Glu Gln Ser Glu Val Glu Glu Thr Ile Glu Ala Thr Lys Ala Glu 
     450                455                460
Glu Ala Lys Asp Glu Pro Pro Ser Glu Gly Glu Ala Glu Glu Glu Glu 
 465                470                475                480
Lys Glu Lys Glu Glu Gly Glu Glu Glu Glu Gly Ala Glu Glu Glu Glu 
                 485                490                495
Ala Ala Lys Asp Glu Ser Glu Asp Ala Lys Glu Glu Glu Gly Gly Glu 
             500                505                510
Gly Glu Glu Glu Asp Thr Lys Glu Ser Glu Glu Glu Glu Lys Lys Glu 
         515                520                525
Glu Ser Ala Gly Glu Glu Gln Ala Ala Lys Lys Lys Asp 
     530                535                540



<210> 3515
<211> 1632
<212> DNA
<213> Homo sapiens
<308> XM_005159
<400> 3515

atgagttcc  tcagctacg  gccgtacta  tcgacctcc  acaagcggc  ctacgtgga  60
acgccccgg  tgcacatct  cagcgtgcg  agcggctac  gcaccgcac  ctcagctta  120
tccagctac  cggcgccgg  gtcttcctc  ctgtccgtg  gccgcagct  ctcctccag  180
tctggatcg  tgatgccca  tctggagaa  ctcgacctg  gccaggtag  cgccatcag  240
aacgacctc  agtccatcc  cacgcagga  aaggcgcag  tccaggacc  caatgaccg  300
ttcgccagc  tcatcgagc  cgtgcacga  ctggagcag  agaacaagg  cctggaagc  360
gagctgctg  tgctgcgcc  gaagcactc  gagccatcc  gcttccggg  gctgtacga  420
caggagatc  gcgacctgc  cctggcggc  gaagatgcc  ccaacgaga  gcaggcgct  480
cagggcgag  gcgaagggc  ggaggagac  ctgcgcaac  tgcaggcgc  ctatgaaga  540
gaggtgctg  gccgcgagg  cgccgaggg  cggctgatg  aagcgcgca  aggcgccga  600
gaggcggcg  tcgctcgcg  cgagctcga  aagcgcatc  acagcttga  ggacgaaat  660
tcttttctg  agaaagtgc  cgaagagga  atcgccgaa  tgcaggcgc  gatccagta  720
gcgcagatc  ccgtggaga  ggacgtgac  aagcccgac  tttccgccg  gctcaagga  780
atccgcgcg  agtacgaga  gctggccgc  aagaacatg  agaacgctg  ggaatggtt  840
aagagccgc  tcaccgtgc  gaccgagag  gccgccaag  acaccgacg  cgtgcgcgc  900
gccaaggac  aggtgtccg  gagccgtcg  ctgctcaag  ccaagaccc  ggaaatcga  960
gcatgccgg  gcatgaatg  agcgctgga  aagcagctg  aggagctgg  ggacaagca  1020
aacgccgac  tcagcgcta  gcaggacac  atcaacaaa  tagaaaatg  attgaggac  1080
acaaagagt  aaatggcac  atacctaaa  gaataccaa  acctcctca  cgtgaagat  1140
gctttggat  ttgagattg  agcttacag  aaactcttg  aaggcgagg  gacccgact  1200
agtttcacc  gcgtgggaa  cataaccag  ggctactcc  agagctccc  ggtctttgg  1260
cgatctgcc  acggcggtt  acagaccag  tcctatctg  tgtccaccc  ctccttccc  1320
tcctactac  ccagccatg  ccaagagga  cagatcgaa  tggaggaaa  cattgaggc  1380
gccaaggct  aggaagcca  ggatgagcc  ccctctgaa  gagaagccg  ggaggagga  1440
aaggacaag  aagaggccg  ggaagagga  gcagctgaa  aggaagaag  tgccaagga  1500
gagtctgaa  aagcaaaag  agaagaaga  ggaggtgaa  gtgaagaag  agaggaaac  1560
aaagaagct  aagaggagg  gaagaaagt  gaaggtgct  gggaggaac  agcagctaa  1620
aagaaagat  ga  1632



<210> 3516
<211> 543
<212> PRT
<213> Homo sapiens
<308> XP_005159
<400> 3516

Met Ser Ser Phe Ser Tyr Glu Pro Tyr Tyr Ser Thr Ser Tyr Lys Arg 
  1               5                  10                  15
Arg Tyr Val Glu Thr Pro Arg Val His Ile Ser Ser Val Arg Ser Gly 
             20                  25                  30
Tyr Ser Thr Ala Arg Ser Ala Tyr Ser Ser Tyr Ser Ala Pro Val Ser 
         35                  40                  45
Ser Ser Leu Ser Val Arg Arg Ser Tyr Ser Ser Ser Ser Gly Ser Leu 
     50                  55                  60
Met Pro Ser Leu Glu Asn Leu Asp Leu Ser Gln Val Ala Ala Ile Ser 
 65                  70                  75                  80
Asn Asp Leu Lys Ser Ile Arg Thr Gln Glu Lys Ala Gln Leu Gln Asp 
                 85                  90                  95
Leu Asn Asp Arg Phe Ala Ser Phe Ile Glu Arg Val His Glu Leu Glu 
             100                105                110
Gln Gln Asn Lys Val Leu Glu Ala Glu Leu Leu Val Leu Arg Gln Lys 
         115                120                125
His Ser Glu Pro Ser Arg Phe Arg Ala Leu Tyr Glu Gln Glu Ile Arg 
     130                135                140
Asp Leu Arg Leu Ala Ala Glu Asp Ala Thr Asn Glu Lys Gln Ala Leu 
 145                150                155                160
Gln Gly Glu Arg Glu Gly Leu Glu Glu Thr Leu Arg Asn Leu Gln Ala 
                 165                170                175
Arg Tyr Glu Glu Glu Val Leu Ser Arg Glu Asp Ala Glu Gly Arg Leu 
             180                185                190
Met Glu Ala Arg Lys Gly Ala Asp Glu Ala Ala Leu Ala Arg Ala Glu 
         195                200                205
Leu Glu Lys Arg Ile Asp Ser Leu Met Asp Glu Ile Ser Phe Leu Lys 
     210                215                220
Lys Val His Glu Glu Glu Ile Ala Glu Leu Gln Ala Gln Ile Gln Tyr 
 225                230                235                240
Ala Gln Ile Ser Val Glu Met Asp Val Thr Lys Pro Asp Leu Ser Ala 
                 245                250                255
Ala Leu Lys Asp Ile Arg Ala Gln Tyr Glu Lys Leu Ala Ala Lys Asn 
             260                265                270
Met Gln Asn Ala Glu Glu Trp Phe Lys Ser Arg Phe Thr Val Leu Thr 
         275                280                285
Glu Ser Ala Ala Lys Asn Thr Asp Ala Val Arg Ala Ala Lys Asp Glu 
     290                295                300
Val Ser Glu Ser Arg Arg Leu Leu Lys Ala Lys Thr Leu Glu Ile Glu 
 305                310                315                320
Ala Cys Arg Gly Met Asn Glu Ala Leu Glu Lys Gln Leu Gln Glu Leu 
                 325                330                335
Glu Asp Lys Gln Asn Ala Asp Ile Ser Ala Met Gln Asp Thr Ile Asn 
             340                345                350
Lys Leu Glu Asn Glu Leu Arg Thr Thr Lys Ser Glu Met Ala Arg Tyr 
         355                360                365
Leu Lys Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile 
     370                375                380
Glu Ile Ala Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Thr Arg Leu 
 385                390                395                400
Ser Phe Thr Ser Val Gly Ser Ile Thr Ser Gly Tyr Ser Gln Ser Ser 
                 405                410                415
Gln Val Phe Gly Arg Ser Ala Tyr Gly Gly Leu Gln Thr Ser Ser Tyr 
             420                425                430
Leu Met Ser Thr Arg Ser Phe Pro Ser Tyr Tyr Thr Ser His Val Gln 
         435                440                445
Glu Glu Gln Ile Glu Val Glu Glu Thr Ile Glu Ala Ala Lys Ala Glu 
     450                455                460
Glu Ala Lys Asp Glu Pro Pro Ser Glu Gly Glu Ala Glu Glu Glu Glu 
 465                470                475                480
Lys Asp Lys Glu Glu Ala Glu Glu Glu Glu Ala Ala Glu Glu Glu Glu 
                 485                490                495
Ala Ala Lys Glu Glu Ser Glu Glu Ala Lys Glu Glu Glu Glu Gly Gly 
             500                505                510
Glu Gly Glu Glu Gly Glu Glu Thr Lys Glu Ala Glu Glu Glu Glu Lys 
         515                520                525
Lys Val Glu Gly Ala Gly Glu Glu Gln Ala Ala Lys Lys Lys Asp 
     530                535                540



<210> 3517
<211> 602
<212> DNA
<213> Rattus norvegicus
<308> M25646
<400> 3517

gctgcacgc  gtgcccacc  atgctcgcc  tgatgctca  cactacgct  tctgcttgc  60
tcctgagcc  gctggccct  acctctgcc  gctacttcc  gaactgccc  agaggaggc  120
agagggcca  atccgacat  gagctgaga  agtgtctcc  ctgcggccc  ggcggcaaa  180
ggcgctgct  cgggccgag  atctgctgc  cggacgagc  gggctgctt  ctgggcacc  240
ccgaggcgc  gcgctgcca  gaggagaac  acctgccct  gccctgcca  tctggccag  300
agccttgcg  aagcggagg  cgctgcgct  ccgcgggca  ctgctgcag  gatgagagc  360
gcgtggccg  gcccgagtg  cgagagggt  ttttccgcc  cacccgcgc  cgggagcag  420
gcaacgcca  gcagctgga  gggccagcc  gggagctgc  gcttaggct  gtacagctg  480
ctgggacac  agagtccgt  gattctgcc  agccccggg  ctactgagc  atcgccccc  540
acgcctccc  cctacagca  ggaaaataa  cttttaaaa  atgcaaaaa  aaaaaaaaa  600
aa  602



<210> 3518
<211> 168
<212> PRT
<213> Rattus norvegicus
<308> P01186
<400> 3518

Met Leu Ala Met Met Leu Asn Thr Thr Leu Ser Ala Cys Phe Leu Ser 
  1               5                  10                  15
Leu Leu Ala Leu Thr Ser Ala Cys Tyr Phe Gln Asn Cys Pro Arg Gly 
             20                  25                  30
Gly Lys Arg Ala Thr Ser Asp Met Glu Leu Arg Gln Cys Leu Pro Cys 
         35                  40                  45
Gly Pro Gly Gly Lys Gly Arg Cys Phe Gly Pro Ser Ile Cys Cys Ala 
     50                  55                  60
Asp Glu Leu Gly Cys Phe Leu Gly Thr Ala Glu Ala Leu Arg Cys Gln 
 65                  70                  75                  80
Glu Glu Asn Tyr Leu Pro Ser Pro Cys Gln Ser Gly Gln Lys Pro Cys 
                 85                  90                  95
Gly Ser Gly Gly Arg Cys Ala Ala Ala Gly Ile Cys Cys Ser Asp Glu 
             100                105                110
Ser Cys Val Ala Glu Pro Glu Cys Arg Glu Gly Phe Phe Arg Leu Thr 
         115                120                125
Arg Ala Arg Glu Gln Ser Asn Ala Thr Gln Leu Asp Gly Pro Ala Arg 
     130                135                140
Glu Leu Leu Leu Arg Leu Val Gln Leu Ala Gly Thr Gln Glu Ser Val 
 145                150                155                160
Asp Ser Ala Lys Pro Arg Val Tyr 
                 165



<210> 3519
<211> 2297
<212> DNA
<213> Rattus norvegicus
<308> M25804
<400> 3519

agacctgaa  ggggaattt  ctaaatctc  aggctggac  gtttgtttc  ccctctcac  60
tcctataac  catctgagt  ttatctcca  atcacattt  taagtctct  gtactcaga  120
tcattgtga  tcttgggag  ccagagcca  gctgaacag  gtccttccc  gcagtactc  180
atgagaata  gtctttggg  ttgaaagaa  ggtggtgtt  tcacctaca  tggctccag  240
ggatcctcc  ccagccgga  cagcccaga  tccctctat  gtgacagct  caatggcag  300
ttccagtcc  tgactcaag  ttgtcccac  tacttccca  catcaccta  tggctccct  360
acccaggac  ctgcccgct  atttggcac  gtgccaccc  gcctcagtg  tgatagctc  420
ccttcttct  cttcatcat  atcatcatc  tcctcctcc  ccttctata  tgggagccc  480
cccggaagt  tacaagtgg  catggaaga  agcagccga  tgtccccca  caagggcac  540
agcaacatt  ccaagctta  cggcatggt  ctactgtgt  aagtgtgtg  ggacgtggc  600
tcaggcttc  actatggcg  gcatgcctg  gagggctgc  agggctttt  ccgccggag  660
atccagcag  acatccagt  caagcggtg  ttgaaaaac  agaactgct  cattgtccg  720
atcaatcgc  accgctgcc  gcagtgtcg  ttcaagaag  gtctctccg  tggcatgtc  780
agagacgct  tgcgttttg  acgtatccc  aagagagag  agcaacgaa  gcttgctga  840
atgcagaac  ccatgaact  ggccaacaa  caactgagc  gcctgtgcc  tctagagac  900
tcacctgcc  cgcacccca  ctcaggctc  gtgggcccc  caccacctc  tgcaccagc  960
ccgacacct  tggtgggct  ctctcagtt  ccacaacag  tgacaccac  cagatcccc  1020
agtcctgag  ccacggtgg  ggatgtgat  tcccaggtg  ccagggccc  tcgagaaat  1080
ttcacctat  cccatgaca  attaggcac  tcacctggc  acttcaatg  caatcatgc  1140
tcaggtagc  ctccggcta  cactccaca  tgctgggag  gtcagggat  cccgtctac  1200
cccaacgac  acaaccttt  ggcggctca  cgtcataat  aagcactga  tggtctacg  1260
cagggcccc  cctcctacc  tcctacctg  ccttctggc  ctgcccacc  cagctgcca  1320
cagcctaac  gcaatgggc  tcgcctgtg  cccacccac  tatactcgg  cccagaagg  1380
aaggcacct  ccaacggtc  acggcaagg  aacaccaag  atgttctgc  ggcatgtcc  1440
atgaacatg  atccccatg  acgtagtgg  cggactgtg  aggagatct  ggaagactt  1500
tctatgagc  tcacacccg  tgtgcggga  gtggtagaa  ttgccaaac  gatccccgg  1560
ttccgtgac  tttctcagc  cgaccaggt  accctgctt  aggctggca  ctttgaggt  1620
ctgatggtg  gctttgcgt  attgttcaa  gtgaaggac  agacagtca  gttcctgag  1680
cgcacaacc  acagcctgc  ggagctcgg  gccatgggc  tgggtgacc  gctcaatgc  1740
atgtttgac  tcagcgaga  gctcaactc  ctggcgctt  ctgaggagg  gctgggcct  1800
ttcacggca  tggtacttg  ctctgcaga  ggctcggga  tggagaatt  cgcttcggt  1860
gagcagctc  aggagacgc  gctgggggc  cttcgggct  tcgtgctga  gaaccggcc  1920
tcggagact  cccgcttca  caaactgct  ctcaagctg  cggacctgc  gaccctgaa  1980
aacatgcat  ccgagaagc  gctgtcctt  cgggtggac  cccagtgac  cgcccggcc  2040
gccttctgc  gctgccccc  tgtacagaa  cgaactctg  acttctctc  cctttacga  2100
acgaaaagg  aaaccaaac  agaatctta  ttatattgt  ataaaatat  ccaagatga  2160
cctctggcc  cctgagcct  cttgtaaat  actcttccc  cccaccccc  tgctccctt  2220
ctcccgtat  taaaccact  ttgctctcc  accctcctc  ggcccctcg  tttgttctg  2280
tcctgtctc  aatccaa  2297



<210> 3520
<211> 508
<212> PRT
<213> Rattus norvegicus
<308> Q63503
<400> 3520

Met Glu Asp Ser Ser Arg Val Ser Pro Ser Lys Gly Thr Ser Asn Ile 
  1               5                  10                  15
Thr Lys Leu Asn Gly Met Val Leu Leu Cys Lys Val Cys Gly Asp Val 
             20                  25                  30
Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly 
         35                  40                  45
Phe Phe Arg Arg Ser Ile Gln Gln Asn Ile Gln Tyr Lys Arg Cys Leu 
     50                  55                  60
Lys Asn Glu Asn Cys Ser Ile Val Arg Ile Asn Arg Asn Arg Cys Gln 
 65                  70                  75                  80
Gln Cys Arg Phe Lys Lys Cys Leu Ser Val Gly Met Ser Arg Asp Ala 
                 85                  90                  95
Val Arg Phe Gly Arg Ile Pro Lys Arg Glu Lys Gln Arg Met Leu Ala 
             100                105                110
Glu Met Gln Asn Ala Met Asn Leu Ala Asn Asn Gln Leu Ser Ser Leu 
         115                120                125
Cys Pro Leu Glu Thr Ser Pro Ala Pro His Pro Thr Ser Gly Ser Val 
     130                135                140
Gly Pro Ser Pro Pro Pro Ala Pro Ala Pro Thr Pro Leu Val Gly Phe 
 145                150                155                160
Ser Gln Phe Pro Gln Gln Leu Thr Pro Pro Arg Ser Pro Ser Pro Glu 
                 165                170                175
Pro Thr Val Glu Asp Val Ile Ser Gln Val Ala Arg Ala His Arg Glu 
             180                185                190
Ile Phe Thr Tyr Ala His Asp Lys Leu Gly Thr Ser Pro Gly Asn Phe 
         195                200                205
Asn Ala Asn His Ala Ser Gly Ser Pro Pro Ala Thr Thr Pro Gln Cys 
     210                215                220
Trp Glu Ser Gln Gly Cys Pro Ser Thr Pro Asn Asp Asn Asn Leu Leu 
 225                230                235                240
Ala Ala Gln Arg His Asn Glu Ala Leu Asn Gly Leu Arg Gln Gly Pro 
                 245                250                255
Ser Ser Tyr Pro Pro Thr Trp Pro Ser Gly Pro Ala His His Ser Cys 
             260                265                270
His Gln Pro Asn Ser Asn Gly His Arg Leu Cys Pro Thr His Val Tyr 
         275                280                285
Ser Ala Pro Glu Gly Lys Ala Pro Ala Asn Gly Leu Arg Gln Gly Asn 
     290                295                300
Thr Lys Asn Val Leu Leu Ala Cys Pro Met Asn Met Tyr Pro His Gly 
 305                310                315                320
Arg Ser Gly Arg Thr Val Gln Glu Ile Trp Glu Asp Phe Ser Met Ser 
                 325                330                335
Phe Thr Pro Ala Val Arg Glu Val Val Glu Phe Ala Lys Gln Ile Pro 
             340                345                350
Gly Phe Arg Asp Leu Ser Gln His Asp Gln Val Thr Leu Leu Lys Ala 
         355                360                365
Gly Thr Phe Glu Val Leu Met Val Arg Phe Ala Ser Leu Phe Asn Val 
     370                375                380
Lys Asp Gln Thr Val Met Phe Leu Ser Arg Thr Thr Tyr Ser Leu Gln 
 385                390                395                400
Glu Leu Gly Ala Met Gly Met Gly Asp Leu Leu Asn Ala Met Phe Asp 
                 405                410                415
Phe Ser Glu Lys Leu Asn Ser Leu Ala Leu Thr Glu Glu Glu Leu Gly 
             420                425                430
Leu Phe Thr Ala Val Val Leu Val Ser Ala Glu Gly Ser Gly Met Glu 
         435                440                445
Asn Ser Ala Ser Val Glu Gln Leu Gln Glu Thr Leu Leu Gly Ala Leu 
     450                455                460
Arg Ala Leu Val Leu Lys Asn Arg Pro Ser Glu Thr Ser Arg Phe Thr 
 465                470                475                480
Lys Leu Leu Leu Lys Leu Pro Asp Leu Arg Thr Leu Asn Asn Met His 
                 485                490                495
Ser Glu Lys Leu Leu Ser Phe Arg Val Asp Ala Gln 
             500                505



<210> 3521
<211> 2768
<212> DNA
<213> Homo sapiens
<308> NM_021724
<400> 3521

ccgaggcgc  ccctgggat  acatggtac  tgctccagt  ccgcgtgcg  cccgggaac  60
ctgggctgc  ggcgcctgc  cagagccct  tgtcccagg  aaaggctcg  gcaaaaggc  120
gctgagatt  gcagagtga  atattactg  cgagggaac  tagcagggc  cacgtctcg  180
ctctttgcg  ctcggtgcc  cgtttctcc  catcaccta  ttacttcct  gttgcaacc  240
ctcttcctc  gggactttt  caccgggag  tccagattc  ctaccccgc  gcgctgcgg  300
gccggcagg  agaggcacc  cgtacactg  agagacccg  ccctccttg  taccttcta  360
ccagaacta  tgcaggctg  ttcccccta  acactctct  tgctcttcc  atgcaaagc  420
gaactccgt  gcctcaacg  ccaaccctt  tgcagggct  cagtccggc  accccaaga  480
cttgctgca  ggtgcttcg  atcctgatc  tgagtcgcg  ggtccactc  ccgccctta  540
ccagtgccc  gggggcaac  gcggcgatc  caacctcta  tttgagtca  ggtccagtt  600
gaatgaccg  tctcagctg  tgaagacat  acgaccctg  actccaaca  caacacagg  660
ggcgtcatc  cctacattg  ctccagtgg  tcctcccca  gccgcacca  ccctgaatc  720
ctctatagt  acaactcca  tggcagctt  cagtccctg  cccaaggct  tcccaccta  780
ttcccacca  cccccactg  ctccctcac  caagacccg  ctcgctcct  tgggagcat  840
ccacccagc  tgagtgatg  cggctcccc  tcttcctca  cttcctcgt  gtcatcctc  900
tcctccttc  ataatggga  cccccctgg  agtctacaa  tggccatgg  ggacagcag  960
cgagtgtcc  ccagcaaga  caccagcaa  atcaccaag  tgaatggca  ggtgttact  1020
tgtaaagtg  gtggggacg  tgcctcggg  ttccactac  gtgtgcacg  ctgcgaggg  1080
tgcaagggc  ttttccgtc  gagcatcca  cagaacatc  agtacaaaa  gtgtctgaa  1140
aatgagaat  gctccatcg  ccgcatcaa  cgcaaccgc  gccagcaat  tcgcttcaa  1200
aagtgtctc  ctgtgggca  gtctcgaga  gctgtgcgt  ttgggcgca  ccccaaacg  1260
gagaagcag  ggatgcttg  tgagatgca  agtgccatg  acctggcca  caaccagtt  1320
agcagccag  gcccgctgg  gacttcacc  acccagcac  ccaccccag  ccccatggg  1380
ccctcgcca  cccctgctc  ggtcccctc  cccctggtg  gcttctccc  gtttccaca  1440
cagctgacg  ctcccagat  cccaagccc  gagcccaca  tggaggatg  gatatccca  1500
gtggcccgg  cccatcgag  gatcttcac  tacgcccat  acaagctgg  cagctcacc  1560
ggcaacttc  atgccaacc  tgcatcagg  agccctcca  ccaccaccc  acatcgctg  1620
gaaaatcag  gctgcccac  tgcccccaa  gacaacaac  ccttggctg  ccagcgtca  1680
aacgaggcc  taaatggtc  gcgccaggc  ccctcctcc  accctccca  ctggcctcc  1740
ggccctgca  accacagct  ccaccagtc  aacagcaac  ggcaccgtc  atgccccac  1800
cacgtgtat  cagccccag  aggcaaggc  cctgccaac  gtccccggc  gggcaactc  1860
aagaatgtt  tgctggcat  tcctatgaa  atgtacccg  atggacgca  tgggcgaac  1920
gtgcaggag  tctgggagg  tttctccat  agcttcacg  ccgctgtgc  ggaggtggt  1980
gagtttgcc  aacacatcc  gggcttccg  gacctttct  agcatgacc  agtcaccct  2040
cttaaggct  gcacctttg  ggtgctgat  gtgcgcttt  cttcgttgt  caacgtgaa  2100
gaccagaca  tgatgttcc  aagccgcac  acctacagc  tgcaggagc  tggtgccat  2160
ggcatggga  acctgctca  tgccatgtt  gacttcagc  agaagctca  ctccctggc  2220
cttaccgag  aggagctgg  cctcttcac  gcggtggtg  ttgtctctg  agaccgctc  2280
ggcatggag  attccgctt  ggtggagca  ctccaggag  cgctgctgc  ggctcttcg  2340
gctctggtg  tgaagaacc  gcccttgga  acttcccgc  tcaccaagc  gctgctcaa  2400
ctgccggac  tgcggaccc  gaacaacat  cattccgag  agctgctgt  cttccgggt  2460
gacgcccag  gacccgccc  gccggcctt  tgccgctgc  cccttgtac  gaatcgaac  2520
ctgcacttc  ctctccttt  cgagacgaa  aggaaaagc  aaccagaat  ttatttata  2580
tgttataaa  tattccaag  tgagcctct  gccccctga  ccttcttgt  aatacctgc  2640
tccctcccc  atcaccgaa  ttcccctcc  cccctattt  aaccactct  tctccccca  2700
aaccctccc  tggccctct  atttgttct  ttcctgtct  aaatccaat  gttcacagc  2760
gagctggg  2768



<210> 3522
<211> 614
<212> PRT
<213> Homo sapiens
<308> P20393
<400> 3522

Met Thr Thr Leu Asp Ser Asn Asn Asn Thr Gly Gly Val Ile Thr Tyr 
  1               5                  10                  15
Ile Gly Ser Ser Gly Ser Ser Pro Ser Arg Thr Ser Pro Glu Ser Leu 
             20                  25                  30
Tyr Ser Asp Asn Ser Asn Gly Ser Phe Gln Ser Leu Thr Gln Gly Cys 
         35                  40                  45
Pro Thr Tyr Phe Pro Pro Ser Pro Thr Gly Ser Leu Thr Gln Asp Pro 
     50                  55                  60
Ala Arg Ser Phe Gly Ser Ile Pro Pro Ser Leu Ser Asp Asp Gly Ser 
 65                  70                  75                  80
Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Phe Tyr Asn 
                 85                  90                  95
Gly Ser Pro Pro Gly Ser Leu Gln Val Ala Met Glu Asp Ser Ser Arg 
             100                105                110
Val Ser Pro Ser Lys Ser Thr Ser Asn Ile Thr Lys Leu Asn Gly Met 
         115                120                125
Val Leu Leu Cys Lys Val Cys Gly Asp Val Ala Ser Gly Phe His Tyr 
     130                135                140
Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Ile 
 145                150                155                160
Gln Gln Asn Ile Gln Tyr Lys Arg Cys Leu Lys Asn Glu Asn Cys Ser 
                 165                170                175
Ile Val Arg Ile Asn Arg Asn Arg Cys Gln Gln Cys Arg Phe Lys Lys 
             180                185                190
Cys Leu Ser Val Gly Met Ser Arg Asp Ala Val Arg Phe Gly Arg Ile 
         195                200                205
Pro Lys Arg Glu Lys Gln Arg Met Leu Ala Glu Met Gln Ser Ala Met 
     210                215                220
Asn Leu Ala Asn Asn Gln Leu Ser Ser Gln Cys Pro Leu Glu Thr Ser 
 225                230                235                240
Pro Thr Gln His Pro Thr Pro Gly Pro Met Gly Pro Ser Pro Pro Pro 
                 245                250                255
Ala Pro Val Pro Ser Pro Leu Val Gly Phe Ser Gln Phe Pro Gln Gln 
             260                265                270
Leu Thr Pro Pro Arg Ser Pro Ser Pro Glu Pro Thr Val Glu Asp Val 
         275                280                285
Ile Ser Gln Val Ala Arg Ala His Arg Glu Ile Phe Thr Tyr Ala His 
     290                295                300
Asp Lys Leu Gly Ser Ser Pro Gly Asn Phe Asn Ala Asn His Ala Ser 
 305                310                315                320
Gly Ser Pro Pro Ala Thr Thr Pro His Arg Trp Glu Asn Gln Gly Cys 
                 325                330                335
Pro Pro Ala Pro Asn Asp Asn Asn Thr Leu Ala Ala Gln Arg His Asn 
             340                345                350
Glu Ala Leu Asn Gly Leu Arg Gln Ala Pro Ser Ser Tyr Pro Pro Thr 
         355                360                365
Trp Pro Pro Gly Pro Ala His His Ser Cys His Gln Ser Asn Ser Asn 
     370                375                380
Gly His Arg Leu Cys Pro Thr His Val Tyr Ala Ala Pro Glu Gly Lys 
 385                390                395                400
Ala Pro Ala Asn Ser Pro Arg Gln Gly Asn Ser Lys Asn Val Leu Leu 
                 405                410                415
Ala Cys Pro Met Asn Met Tyr Pro His Gly Arg Ser Gly Arg Thr Val 
             420                425                430
Gln Glu Ile Trp Glu Asp Phe Ser Met Ser Phe Thr Pro Ala Val Arg 
         435                440                445
Glu Val Val Glu Phe Ala Lys His Ile Pro Gly Phe Arg Asp Leu Ser 
     450                455                460
Gln His Asp Gln Val Thr Leu Leu Lys Ala Gly Thr Phe Glu Val Leu 
 465                470                475                480
Met Val Arg Phe Ala Ser Leu Phe Asn Val Lys Asp Gln Thr Val Met 
                 485                490                495
Phe Leu Ser Arg Thr Thr Tyr Ser Leu Gln Glu Leu Gly Ala Met Gly 
             500                505                510
Met Gly Asp Leu Leu Ser Ala Met Phe Asp Phe Ser Glu Lys Leu Asn 
         515                520                525
Ser Leu Ala Leu Thr Glu Glu Glu Leu Gly Leu Phe Thr Ala Val Val 
     530                535                540
Leu Val Ser Ala Asp Arg Ser Gly Met Glu Asn Ser Ala Ser Val Glu 
 545                550                555                560
Gln Leu Gln Glu Thr Leu Leu Arg Ala Leu Arg Ala Leu Val Leu Lys 
                 565                570                575
Asn Arg Pro Leu Glu Thr Ser Arg Phe Thr Lys Leu Leu Leu Lys Leu 
             580                585                590
Pro Asp Leu Arg Thr Leu Asn Asn Met His Ser Glu Lys Leu Leu Ser 
         595                600                605
Phe Arg Val Asp Ala Gln 
     610



<210> 3523
<211> 2297
<212> DNA
<213> Rattus norvegicus
<308> M25804
<400> 3523

agacctgaa  ggggaattt  ctaaatctc  aggctggac  gtttgtttc  ccctctcac  60
tcctataac  catctgagt  ttatctcca  atcacattt  taagtctct  gtactcaga  120
tcattgtga  tcttgggag  ccagagcca  gctgaacag  gtccttccc  gcagtactc  180
atgagaata  gtctttggg  ttgaaagaa  ggtggtgtt  tcacctaca  tggctccag  240
ggatcctcc  ccagccgga  cagcccaga  tccctctat  gtgacagct  caatggcag  300
ttccagtcc  tgactcaag  ttgtcccac  tacttccca  catcaccta  tggctccct  360
acccaggac  ctgcccgct  atttggcac  gtgccaccc  gcctcagtg  tgatagctc  420
ccttcttct  cttcatcat  atcatcatc  tcctcctcc  ccttctata  tgggagccc  480
cccggaagt  tacaagtgg  catggaaga  agcagccga  tgtccccca  caagggcac  540
agcaacatt  ccaagctta  cggcatggt  ctactgtgt  aagtgtgtg  ggacgtggc  600
tcaggcttc  actatggcg  gcatgcctg  gagggctgc  agggctttt  ccgccggag  660
atccagcag  acatccagt  caagcggtg  ttgaaaaac  agaactgct  cattgtccg  720
atcaatcgc  accgctgcc  gcagtgtcg  ttcaagaag  gtctctccg  tggcatgtc  780
agagacgct  tgcgttttg  acgtatccc  aagagagag  agcaacgaa  gcttgctga  840
atgcagaac  ccatgaact  ggccaacaa  caactgagc  gcctgtgcc  tctagagac  900
tcacctgcc  cgcacccca  ctcaggctc  gtgggcccc  caccacctc  tgcaccagc  960
ccgacacct  tggtgggct  ctctcagtt  ccacaacag  tgacaccac  cagatcccc  1020
agtcctgag  ccacggtgg  ggatgtgat  tcccaggtg  ccagggccc  tcgagaaat  1080
ttcacctat  cccatgaca  attaggcac  tcacctggc  acttcaatg  caatcatgc  1140
tcaggtagc  ctccggcta  cactccaca  tgctgggag  gtcagggat  cccgtctac  1200
cccaacgac  acaaccttt  ggcggctca  cgtcataat  aagcactga  tggtctacg  1260
cagggcccc  cctcctacc  tcctacctg  ccttctggc  ctgcccacc  cagctgcca  1320
cagcctaac  gcaatgggc  tcgcctgtg  cccacccac  tatactcgg  cccagaagg  1380
aaggcacct  ccaacggtc  acggcaagg  aacaccaag  atgttctgc  ggcatgtcc  1440
atgaacatg  atccccatg  acgtagtgg  cggactgtg  aggagatct  ggaagactt  1500
tctatgagc  tcacacccg  tgtgcggga  gtggtagaa  ttgccaaac  gatccccgg  1560
ttccgtgac  tttctcagc  cgaccaggt  accctgctt  aggctggca  ctttgaggt  1620
ctgatggtg  gctttgcgt  attgttcaa  gtgaaggac  agacagtca  gttcctgag  1680
cgcacaacc  acagcctgc  ggagctcgg  gccatgggc  tgggtgacc  gctcaatgc  1740
atgtttgac  tcagcgaga  gctcaactc  ctggcgctt  ctgaggagg  gctgggcct  1800
ttcacggca  tggtacttg  ctctgcaga  ggctcggga  tggagaatt  cgcttcggt  1860
gagcagctc  aggagacgc  gctgggggc  cttcgggct  tcgtgctga  gaaccggcc  1920
tcggagact  cccgcttca  caaactgct  ctcaagctg  cggacctgc  gaccctgaa  1980
aacatgcat  ccgagaagc  gctgtcctt  cgggtggac  cccagtgac  cgcccggcc  2040
gccttctgc  gctgccccc  tgtacagaa  cgaactctg  acttctctc  cctttacga  2100
acgaaaagg  aaaccaaac  agaatctta  ttatattgt  ataaaatat  ccaagatga  2160
cctctggcc  cctgagcct  cttgtaaat  actcttccc  cccaccccc  tgctccctt  2220
ctcccgtat  taaaccact  ttgctctcc  accctcctc  ggcccctcg  tttgttctg  2280
tcctgtctc  aatccaa  2297



<210> 3524
<211> 508
<212> PRT
<213> Rattus norvegicus
<308> Q63503
<400> 3524

Met Glu Asp Ser Ser Arg Val Ser Pro Ser Lys Gly Thr Ser Asn Ile 
  1               5                  10                  15
Thr Lys Leu Asn Gly Met Val Leu Leu Cys Lys Val Cys Gly Asp Val 
             20                  25                  30
Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly 
         35                  40                  45
Phe Phe Arg Arg Ser Ile Gln Gln Asn Ile Gln Tyr Lys Arg Cys Leu 
     50                  55                  60
Lys Asn Glu Asn Cys Ser Ile Val Arg Ile Asn Arg Asn Arg Cys Gln 
 65                  70                  75                  80
Gln Cys Arg Phe Lys Lys Cys Leu Ser Val Gly Met Ser Arg Asp Ala 
                 85                  90                  95
Val Arg Phe Gly Arg Ile Pro Lys Arg Glu Lys Gln Arg Met Leu Ala 
             100                105                110
Glu Met Gln Asn Ala Met Asn Leu Ala Asn Asn Gln Leu Ser Ser Leu 
         115                120                125
Cys Pro Leu Glu Thr Ser Pro Ala Pro His Pro Thr Ser Gly Ser Val 
     130                135                140
Gly Pro Ser Pro Pro Pro Ala Pro Ala Pro Thr Pro Leu Val Gly Phe 
 145                150                155                160
Ser Gln Phe Pro Gln Gln Leu Thr Pro Pro Arg Ser Pro Ser Pro Glu 
                 165                170                175
Pro Thr Val Glu Asp Val Ile Ser Gln Val Ala Arg Ala His Arg Glu 
             180                185                190
Ile Phe Thr Tyr Ala His Asp Lys Leu Gly Thr Ser Pro Gly Asn Phe 
         195                200                205
Asn Ala Asn His Ala Ser Gly Ser Pro Pro Ala Thr Thr Pro Gln Cys 
     210                215                220
Trp Glu Ser Gln Gly Cys Pro Ser Thr Pro Asn Asp Asn Asn Leu Leu 
 225                230                235                240
Ala Ala Gln Arg His Asn Glu Ala Leu Asn Gly Leu Arg Gln Gly Pro 
                 245                250                255
Ser Ser Tyr Pro Pro Thr Trp Pro Ser Gly Pro Ala His His Ser Cys 
             260                265                270
His Gln Pro Asn Ser Asn Gly His Arg Leu Cys Pro Thr His Val Tyr 
         275                280                285
Ser Ala Pro Glu Gly Lys Ala Pro Ala Asn Gly Leu Arg Gln Gly Asn 
     290                295                300
Thr Lys Asn Val Leu Leu Ala Cys Pro Met Asn Met Tyr Pro His Gly 
 305                310                315                320
Arg Ser Gly Arg Thr Val Gln Glu Ile Trp Glu Asp Phe Ser Met Ser 
                 325                330                335
Phe Thr Pro Ala Val Arg Glu Val Val Glu Phe Ala Lys Gln Ile Pro 
             340                345                350
Gly Phe Arg Asp Leu Ser Gln His Asp Gln Val Thr Leu Leu Lys Ala 
         355                360                365
Gly Thr Phe Glu Val Leu Met Val Arg Phe Ala Ser Leu Phe Asn Val 
     370                375                380
Lys Asp Gln Thr Val Met Phe Leu Ser Arg Thr Thr Tyr Ser Leu Gln 
 385                390                395                400
Glu Leu Gly Ala Met Gly Met Gly Asp Leu Leu Asn Ala Met Phe Asp 
                 405                410                415
Phe Ser Glu Lys Leu Asn Ser Leu Ala Leu Thr Glu Glu Glu Leu Gly 
             420                425                430
Leu Phe Thr Ala Val Val Leu Val Ser Ala Glu Gly Ser Gly Met Glu 
         435                440                445
Asn Ser Ala Ser Val Glu Gln Leu Gln Glu Thr Leu Leu Gly Ala Leu 
     450                455                460
Arg Ala Leu Val Leu Lys Asn Arg Pro Ser Glu Thr Ser Arg Phe Thr 
 465                470                475                480
Lys Leu Leu Leu Lys Leu Pro Asp Leu Arg Thr Leu Asn Asn Met His 
                 485                490                495
Ser Glu Lys Leu Leu Ser Phe Arg Val Asp Ala Gln 
             500                505



<210> 3525
<211> 2768
<212> DNA
<213> Homo sapiens
<308> NM_021724
<400> 3525

ccgaggcgc  ccctgggat  acatggtac  tgctccagt  ccgcgtgcg  cccgggaac  60
ctgggctgc  ggcgcctgc  cagagccct  tgtcccagg  aaaggctcg  gcaaaaggc  120
gctgagatt  gcagagtga  atattactg  cgagggaac  tagcagggc  cacgtctcg  180
ctctttgcg  ctcggtgcc  cgtttctcc  catcaccta  ttacttcct  gttgcaacc  240
ctcttcctc  gggactttt  caccgggag  tccagattc  ctaccccgc  gcgctgcgg  300
gccggcagg  agaggcacc  cgtacactg  agagacccg  ccctccttg  taccttcta  360
ccagaacta  tgcaggctg  ttcccccta  acactctct  tgctcttcc  atgcaaagc  420
gaactccgt  gcctcaacg  ccaaccctt  tgcagggct  cagtccggc  accccaaga  480
cttgctgca  ggtgcttcg  atcctgatc  tgagtcgcg  ggtccactc  ccgccctta  540
ccagtgccc  gggggcaac  gcggcgatc  caacctcta  tttgagtca  ggtccagtt  600
gaatgaccg  tctcagctg  tgaagacat  acgaccctg  actccaaca  caacacagg  660
ggcgtcatc  cctacattg  ctccagtgg  tcctcccca  gccgcacca  ccctgaatc  720
ctctatagt  acaactcca  tggcagctt  cagtccctg  cccaaggct  tcccaccta  780
ttcccacca  cccccactg  ctccctcac  caagacccg  ctcgctcct  tgggagcat  840
ccacccagc  tgagtgatg  cggctcccc  tcttcctca  cttcctcgt  gtcatcctc  900
tcctccttc  ataatggga  cccccctgg  agtctacaa  tggccatgg  ggacagcag  960
cgagtgtcc  ccagcaaga  caccagcaa  atcaccaag  tgaatggca  ggtgttact  1020
tgtaaagtg  gtggggacg  tgcctcggg  ttccactac  gtgtgcacg  ctgcgaggg  1080
tgcaagggc  ttttccgtc  gagcatcca  cagaacatc  agtacaaaa  gtgtctgaa  1140
aatgagaat  gctccatcg  ccgcatcaa  cgcaaccgc  gccagcaat  tcgcttcaa  1200
aagtgtctc  ctgtgggca  gtctcgaga  gctgtgcgt  ttgggcgca  ccccaaacg  1260
gagaagcag  ggatgcttg  tgagatgca  agtgccatg  acctggcca  caaccagtt  1320
agcagccag  gcccgctgg  gacttcacc  acccagcac  ccaccccag  ccccatggg  1380
ccctcgcca  cccctgctc  ggtcccctc  cccctggtg  gcttctccc  gtttccaca  1440
cagctgacg  ctcccagat  cccaagccc  gagcccaca  tggaggatg  gatatccca  1500
gtggcccgg  cccatcgag  gatcttcac  tacgcccat  acaagctgg  cagctcacc  1560
ggcaacttc  atgccaacc  tgcatcagg  agccctcca  ccaccaccc  acatcgctg  1620
gaaaatcag  gctgcccac  tgcccccaa  gacaacaac  ccttggctg  ccagcgtca  1680
aacgaggcc  taaatggtc  gcgccaggc  ccctcctcc  accctccca  ctggcctcc  1740
ggccctgca  accacagct  ccaccagtc  aacagcaac  ggcaccgtc  atgccccac  1800
cacgtgtat  cagccccag  aggcaaggc  cctgccaac  gtccccggc  gggcaactc  1860
aagaatgtt  tgctggcat  tcctatgaa  atgtacccg  atggacgca  tgggcgaac  1920
gtgcaggag  tctgggagg  tttctccat  agcttcacg  ccgctgtgc  ggaggtggt  1980
gagtttgcc  aacacatcc  gggcttccg  gacctttct  agcatgacc  agtcaccct  2040
cttaaggct  gcacctttg  ggtgctgat  gtgcgcttt  cttcgttgt  caacgtgaa  2100
gaccagaca  tgatgttcc  aagccgcac  acctacagc  tgcaggagc  tggtgccat  2160
ggcatggga  acctgctca  tgccatgtt  gacttcagc  agaagctca  ctccctggc  2220
cttaccgag  aggagctgg  cctcttcac  gcggtggtg  ttgtctctg  agaccgctc  2280
ggcatggag  attccgctt  ggtggagca  ctccaggag  cgctgctgc  ggctcttcg  2340
gctctggtg  tgaagaacc  gcccttgga  acttcccgc  tcaccaagc  gctgctcaa  2400
ctgccggac  tgcggaccc  gaacaacat  cattccgag  agctgctgt  cttccgggt  2460
gacgcccag  gacccgccc  gccggcctt  tgccgctgc  cccttgtac  gaatcgaac  2520
ctgcacttc  ctctccttt  cgagacgaa  aggaaaagc  aaccagaat  ttatttata  2580
tgttataaa  tattccaag  tgagcctct  gccccctga  ccttcttgt  aatacctgc  2640
tccctcccc  atcaccgaa  ttcccctcc  cccctattt  aaccactct  tctccccca  2700
aaccctccc  tggccctct  atttgttct  ttcctgtct  aaatccaat  gttcacagc  2760
gagctggg  2768



<210> 3526
<211> 614
<212> PRT
<213> Homo sapiens
<308> P20393
<400> 3526

Met Thr Thr Leu Asp Ser Asn Asn Asn Thr Gly Gly Val Ile Thr Tyr 
  1               5                  10                  15
Ile Gly Ser Ser Gly Ser Ser Pro Ser Arg Thr Ser Pro Glu Ser Leu 
             20                  25                  30
Tyr Ser Asp Asn Ser Asn Gly Ser Phe Gln Ser Leu Thr Gln Gly Cys 
         35                  40                  45
Pro Thr Tyr Phe Pro Pro Ser Pro Thr Gly Ser Leu Thr Gln Asp Pro 
     50                  55                  60
Ala Arg Ser Phe Gly Ser Ile Pro Pro Ser Leu Ser Asp Asp Gly Ser 
 65                  70                  75                  80
Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Phe Tyr Asn 
                 85                  90                  95
Gly Ser Pro Pro Gly Ser Leu Gln Val Ala Met Glu Asp Ser Ser Arg 
             100                105                110
Val Ser Pro Ser Lys Ser Thr Ser Asn Ile Thr Lys Leu Asn Gly Met 
         115                120                125
Val Leu Leu Cys Lys Val Cys Gly Asp Val Ala Ser Gly Phe His Tyr 
     130                135                140
Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Ile 
 145                150                155                160
Gln Gln Asn Ile Gln Tyr Lys Arg Cys Leu Lys Asn Glu Asn Cys Ser 
                 165                170                175
Ile Val Arg Ile Asn Arg Asn Arg Cys Gln Gln Cys Arg Phe Lys Lys 
             180                185                190
Cys Leu Ser Val Gly Met Ser Arg Asp Ala Val Arg Phe Gly Arg Ile 
         195                200                205
Pro Lys Arg Glu Lys Gln Arg Met Leu Ala Glu Met Gln Ser Ala Met 
     210                215                220
Asn Leu Ala Asn Asn Gln Leu Ser Ser Gln Cys Pro Leu Glu Thr Ser 
 225                230                235                240
Pro Thr Gln His Pro Thr Pro Gly Pro Met Gly Pro Ser Pro Pro Pro 
                 245                250                255
Ala Pro Val Pro Ser Pro Leu Val Gly Phe Ser Gln Phe Pro Gln Gln 
             260                265                270
Leu Thr Pro Pro Arg Ser Pro Ser Pro Glu Pro Thr Val Glu Asp Val 
         275                280                285
Ile Ser Gln Val Ala Arg Ala His Arg Glu Ile Phe Thr Tyr Ala His 
     290                295                300
Asp Lys Leu Gly Ser Ser Pro Gly Asn Phe Asn Ala Asn His Ala Ser 
 305                310                315                320
Gly Ser Pro Pro Ala Thr Thr Pro His Arg Trp Glu Asn Gln Gly Cys 
                 325                330                335
Pro Pro Ala Pro Asn Asp Asn Asn Thr Leu Ala Ala Gln Arg His Asn 
             340                345                350
Glu Ala Leu Asn Gly Leu Arg Gln Ala Pro Ser Ser Tyr Pro Pro Thr 
         355                360                365
Trp Pro Pro Gly Pro Ala His His Ser Cys His Gln Ser Asn Ser Asn 
     370                375                380
Gly His Arg Leu Cys Pro Thr His Val Tyr Ala Ala Pro Glu Gly Lys 
 385                390                395                400
Ala Pro Ala Asn Ser Pro Arg Gln Gly Asn Ser Lys Asn Val Leu Leu 
                 405                410                415
Ala Cys Pro Met Asn Met Tyr Pro His Gly Arg Ser Gly Arg Thr Val 
             420                425                430
Gln Glu Ile Trp Glu Asp Phe Ser Met Ser Phe Thr Pro Ala Val Arg 
         435                440                445
Glu Val Val Glu Phe Ala Lys His Ile Pro Gly Phe Arg Asp Leu Ser 
     450                455                460
Gln His Asp Gln Val Thr Leu Leu Lys Ala Gly Thr Phe Glu Val Leu 
 465                470                475                480
Met Val Arg Phe Ala Ser Leu Phe Asn Val Lys Asp Gln Thr Val Met 
                 485                490                495
Phe Leu Ser Arg Thr Thr Tyr Ser Leu Gln Glu Leu Gly Ala Met Gly 
             500                505                510
Met Gly Asp Leu Leu Ser Ala Met Phe Asp Phe Ser Glu Lys Leu Asn 
         515                520                525
Ser Leu Ala Leu Thr Glu Glu Glu Leu Gly Leu Phe Thr Ala Val Val 
     530                535                540
Leu Val Ser Ala Asp Arg Ser Gly Met Glu Asn Ser Ala Ser Val Glu 
 545                550                555                560
Gln Leu Gln Glu Thr Leu Leu Arg Ala Leu Arg Ala Leu Val Leu Lys 
                 565                570                575
Asn Arg Pro Leu Glu Thr Ser Arg Phe Thr Lys Leu Leu Leu Lys Leu 
             580                585                590
Pro Asp Leu Arg Thr Leu Asn Asn Met His Ser Glu Lys Leu Leu Ser 
         595                600                605
Phe Arg Val Asp Ala Gln 
     610



<210> 3527
<211> 564
<212> DNA
<213> Rattus norvegicus
<308> M25890
<400> 3527

tgcggacct  cgtctagac  gacccaccg  gctcaagct  ggctgtctg  ggcagggga  60
atgctgtcc  gccgtctcc  gtgcgcgct  gccgcgctc  gcatcgtcc  ggctttggg  120
ggtgtcacc  gggcgccct  ggaccccag  ctccgtcag  ttctgcaga  gtctctggc  180
gctgccacc  ggaaacagg  actggccaa  tacttcttg  cagaactgc  gtctgagcc  240
aaccagaca  agaacgatg  cctggagcc  gaggatttg  cccaggcag  tgagcagga  300
gagatgagg  tggagctgc  gaggtctgc  aactcgaac  cagccatgg  accccggga  360
cgcaaagct  gctgcaaga  cttcttctg  aagacattc  catcctgtt  gctttaata  420
tgttgtctc  gccagacct  tgatccctc  cctccaaat  ccatatctc  tccttaact  480
ccagccccc  ccccaatgc  caactagac  ctgcgttag  aattgaaga  tgtaaatac  540
aaataaaat  atggtgaaa  tatg  564



<210> 3528
<211> 116
<212> PRT
<213> Rattus norvegicus
<308> P01167
<400> 3528

Met Leu Ser Cys Arg Leu Gln Cys Ala Leu Ala Ala Leu Cys Ile Val 
  1               5                  10                  15
Leu Ala Leu Gly Gly Val Thr Gly Ala Pro Ser Asp Pro Arg Leu Arg 
             20                  25                  30
Gln Phe Leu Gln Lys Ser Leu Ala Ala Ala Thr Gly Lys Gln Glu Leu 
         35                  40                  45
Ala Lys Tyr Phe Leu Ala Glu Leu Leu Ser Glu Pro Asn Gln Thr Glu 
     50                  55                  60
Asn Asp Ala Leu Glu Pro Glu Asp Leu Pro Gln Ala Ala Glu Gln Asp 
 65                  70                  75                  80
Glu Met Arg Leu Glu Leu Gln Arg Ser Ala Asn Ser Asn Pro Ala Met 
                 85                  90                  95
Ala Pro Arg Glu Arg Lys Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr 
             100                105                110
Phe Thr Ser Cys 
         115



<210> 3529
<211> 351
<212> DNA
<213> Homo sapiens
<308> NM_001048
<400> 3529

atgctgtcc  gccgcctcc  gtgcgcgct  gctgcgctg  ccatcgtcc  ggccctggg  60
tgtgtcacc  gcgctccct  ggaccccag  ctccgtcag  ttctgcaga  gtccctggc  120
gctgccgcg  ggaagcagg  actggccaa  tacttcttg  cagagctgc  gtctgaacc  180
aaccagacg  agaatgatg  cctggaacc  gaagatctg  cccaggctg  tgagcagga  240
gaaatgagg  ttgagctgc  gagatctgc  aactcaaac  cggctatgg  accccgaga  300
cgcaaagct  gctgcaaga  tttcttctg  aagactttc  catcctgtt  g  351



<210> 3530
<211> 116
<212> PRT
<213> Homo sapiens
<308> RIHUS1
<400> 3530

Met Leu Ser Cys Arg Leu Gln Cys Ala Leu Ala Ala Leu Ser Ile Val 
  1               5                  10                  15
Leu Ala Leu Gly Cys Val Thr Gly Ala Pro Ser Asp Pro Arg Leu Arg 
             20                  25                  30
Gln Phe Leu Gln Lys Ser Leu Ala Ala Ala Ala Gly Lys Gln Glu Leu 
         35                  40                  45
Ala Lys Tyr Phe Leu Ala Glu Leu Leu Ser Glu Pro Asn Gln Thr Glu 
     50                  55                  60
Asn Asp Ala Leu Glu Pro Glu Asp Leu Ser Gln Ala Ala Glu Gln Asp 
 65                  70                  75                  80
Glu Met Arg Leu Glu Leu Gln Arg Ser Ala Asn Ser Asn Pro Ala Met 
                 85                  90                  95
Ala Pro Arg Glu Arg Lys Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr 
             100                105                110
Phe Thr Ser Cys 
         115



<210> 3531
<211> 1733
<212> DNA
<213> Rattus norvegicus
<308> M26125
<400> 3531

gacttggga  gaaccaggg  ctacactta  ccctggtaa  cagcagagc  tgctgggat  60
attcttccc  gaaaaggaa  agcaggcac  tctgttccc  gggaaaaca  caggagcac  120
ttggacctc  ctgctgcag  caggagtca  gtggctgga  cttgtcctg  cttcccttc  180
gggctttgt  atctactgg  ttgtctccc  ggacaagga  gaaacctta  cactaggag  240
tggatggtg  gggccaggg  caaagccat  agccaaaga  gatgagagc  tccggccct  300
caaggtgga  acatcagat  aggagatca  ggacttaca  cagaggata  ataggttcc  360
ggcatcccc  cctttggag  gcagccgct  ccactatgg  ttcaactcc  actacatga  420
gaaagtggt  tcctactgg  ggaacgagt  tgactggag  aagcaggtg  agatcctca  480
ccagtaccc  cacttcaag  ccaagatcg  agggcttga  atccacttc  tccatgtga  540
gcctcccca  ctgccctca  ggcgcaccc  aaagccctt  ctgatggtg  atggctggc  600
tggatcctt  tatgagttt  acaagatca  cccactact  actgacccc  agtcccacg  660
tctgagtga  gagcacgtg  ttgaagtca  ctgtccctc  attcctggc  atggctact  720
agaggcatc  agcaagaaa  gtttaaatt  ggtggccac  gcgaggatt  tctacaagc  780
gatgacacg  ctgggcttc  agaaattct  cattcaagg  ggggactgg  ggtccctca  840
ctgcaccaa  atggcccag  tggttccca  ccacgtgaa  ggcctgcac  taaatatgg  900
tttcatttc  agaagtttt  acaccatga  tcctctcct  ggccaacgc  tcgggagat  960
ccttggcta  acagagaag  atatcgagc  cttgtaccc  tataaggag  aggttttct  1020
cagcatcat  agggagagt  gctacttac  catccaagc  accaagcca  acactgtgg  1080
ctgtgctct  aatgactct  ccgtgggcc  ggctgccta  atcttagag  agttctcca  1140
ctggaccaa  tcagagtac  gtgaactgg  ggatggagg  ctggagagg  agttctccc  1200
ggatgatct  ctggttaac  tcatgatct  ctggacgac  ggaaccatt  tctcctccc  1260
acgctacta  aaggagaat  tgggccagg  catcatggt  cataaacat  aggggatga  1320
ggtctttgt  cccactggc  tttcagcct  cccttccga  ctactgcat  ccccagaaa  1380
gtgggtgaa  gtcaagtac  ccaaactca  ctcctattc  tacatggaa  gtgggggcc  1440
ctttgctgc  tttgaagag  ccaagcttc  ggcccagga  atccgcaag  tcgtgtccc  1500
ggctgagct  cagtagtga  actggatac  aactgtggc  ttagcagca  ccctggttc  1560
tcccaagtc  cacttatgg  agatgaccc  tttctgagg  ataagtttg  tccctgacc  1620
cactcgagg  cccagactt  aactccaca  agtcgtatg  tacccccat  tgcttcacc  1680
cactacata  ctgtgttag  tacatggct  taatgataa  tggatttat  tct  1733



<210> 3532
<211> 455
<212> PRT
<213> Rattus norvegicus
<308> P07687
<400> 3532

Met Trp Leu Glu Leu Val Leu Ala Ser Leu Leu Gly Phe Val Ile Tyr 
  1               5                  10                  15
Trp Phe Val Ser Arg Asp Lys Glu Glu Thr Leu Pro Leu Gly Asp Gly 
             20                  25                  30
Trp Trp Gly Pro Gly Ser Lys Pro Ser Ala Lys Glu Asp Glu Ser Ile 
         35                  40                  45
Arg Pro Phe Lys Val Glu Thr Ser Asp Glu Glu Ile Lys Asp Leu His 
     50                  55                  60
Gln Arg Ile Asp Arg Phe Arg Ala Ser Pro Pro Leu Glu Gly Ser Arg 
 65                  70                  75                  80
Phe His Tyr Gly Phe Asn Ser Asn Tyr Met Lys Lys Val Val Ser Tyr 
                 85                  90                  95
Trp Arg Asn Glu Phe Asp Trp Arg Lys Gln Val Glu Ile Leu Asn Gln 
             100                105                110
Tyr Pro His Phe Lys Thr Lys Ile Glu Gly Leu Asp Ile His Phe Ile 
         115                120                125
His Val Lys Pro Pro Gln Leu Pro Ser Gly Arg Thr Pro Lys Pro Leu 
     130                135                140
Leu Met Val His Gly Trp Pro Gly Ser Phe Tyr Glu Phe Tyr Lys Ile 
 145                150                155                160
Ile Pro Leu Leu Thr Asp Pro Lys Ser His Gly Leu Ser Asp Glu His 
                 165                170                175
Val Phe Glu Val Ile Cys Pro Ser Ile Pro Gly Tyr Gly Tyr Ser Glu 
             180                185                190
Ala Ser Ser Lys Lys Gly Leu Asn Ser Val Ala Thr Ala Arg Ile Phe 
         195                200                205
Tyr Lys Leu Met Thr Arg Leu Gly Phe Gln Lys Phe Tyr Ile Gln Gly 
     210                215                220
Gly Asp Trp Gly Ser Leu Ile Cys Thr Asn Met Ala Gln Met Val Pro 
 225                230                235                240
Asn His Val Lys Gly Leu His Leu Asn Met Ala Phe Ile Ser Arg Ser 
                 245                250                255
Phe Tyr Thr Met Thr Pro Leu Leu Gly Gln Arg Phe Gly Arg Phe Leu 
             260                265                270
Gly Tyr Thr Glu Lys Asp Ile Glu Leu Leu Tyr Pro Tyr Lys Glu Lys 
         275                280                285
Val Phe Tyr Ser Ile Met Arg Glu Ser Gly Tyr Leu His Ile Gln Ala 
     290                295                300
Thr Lys Pro Asp Thr Val Gly Cys Ala Leu Asn Asp Ser Pro Val Gly 
 305                310                315                320
Leu Ala Ala Tyr Ile Leu Glu Lys Phe Ser Thr Trp Thr Lys Ser Glu 
                 325                330                335
Tyr Arg Glu Leu Glu Asp Gly Gly Leu Glu Arg Lys Phe Ser Leu Asp 
             340                345                350
Asp Leu Leu Val Asn Ile Met Ile Tyr Trp Thr Thr Gly Thr Ile Val 
         355                360                365
Ser Ser Gln Arg Tyr Tyr Lys Glu Asn Leu Gly Gln Gly Ile Met Val 
     370                375                380
His Lys His Glu Gly Met Lys Val Phe Val Pro Thr Gly Phe Ser Ala 
 385                390                395                400
Phe Pro Ser Glu Leu Leu His Ala Pro Glu Lys Trp Val Lys Val Lys 
                 405                410                415
Tyr Pro Lys Leu Ile Ser Tyr Ser Tyr Met Glu Arg Gly Gly His Phe 
             420                425                430
Ala Ala Phe Glu Glu Pro Lys Leu Leu Ala Gln Asp Ile Arg Lys Phe 
         435                440                445
Val Ser Leu Ala Glu Leu Gln 
     450                455



<210> 3533
<211> 460
<212> DNA
<213> Homo sapiens
<308> AI636871
<400> 3533

ttttttttc  ctttgnagt  ttatattta  gatttgatg  gacacagtt  tttattgct  60
agtgagcaa  cccctagcc  ccaagtggg  actacaggc  tcagtgctt  ccccacact  120
cctgagcta  cagcccttc  gcactggcc  tcctgccaa  actgcctgc  ctgtcccca  180
tccctctgg  tcccatgat  accagatcc  ccctgcagg  tccctgtca  ctgtggggc  240
ctatccaga  cccctaatc  acttgccta  cagccccac  ctttcctcg  tggctcaga  300
cctgagatc  aaggaacac  ctgggtttc  caaccactc  cttataaaa  tcgtagaaa  360
agccgggcc  gccgtgcac  atcagcaag  gcttcgggg  atggcctgc  ggcagctgg  420
ggggcttca  gtggatgaa  tggatgtcc  gcccttcaat  460



<210> 3534
<211> 1746
<212> DNA
<213> Rattus norvegicus
<308> M26161
<400> 3534

tcctggcct  ctacccctg  accctgcat  catcatgac  gtgatgtca  gggagaatg  60
agacgaggc  tcggccgct  caggtcacc  ccaggatgg  agctaccca  ggcaggcgg  120
ccacgacga  cacgaatgc  gcgagcgcg  ggtgatcaa  atctccggg  tgcgcttcg  180
gacgcagct  aagactctg  cccagttcc  caacacgct  ctgggcaac  cgaagaaac  240
catgcgcta  tttgaccct  tgaggaatg  gtacttctt  gaccgcaac  ggcccagct  300
cgatgccat  ctttattac  accagtcgg  ggggcgcct  cgcaggccg  tcaacgtgc  360
cctggacat  ttctccgag  agattaaat  ttacgagtt  ggcgaggag  ccatggaga  420
gttccggga  gatgagggc  tcatcaagg  agaggagcg  cccctaccc  agaaggagt  480
ccagcgcca  gtgtggctg  tctttgagt  tccggagag  tcaggacct  cacgggtta  540
tgccattgt  tccgtcatg  tcatcctca  ctccatagt  atcttttgc  tggagactc  600
ccctgagct  aaggatgac  aggacttca  gggcaccat  caccgcatc  ataacacca  660
agtcatcta  acttctaac  tcttcacag  ccctttctt  attgtggaa  ccttgtgta  720
catctggtt  tcttttgag  tggtggtgc  cttcttcgc  tgccccagc  agacagact  780
ctttaagaa  atcatgaac  tcatcgaca  tgtggccat  atcccttat  tcattaccc  840
gggcacaga  atagctgag  aggagggga  tcagaaggg  gagcaggcc  cttccctgg  900
catcctcag  gtcatccgc  tggtaaggg  gttcagaat  ttcaaactc  cccgccact  960
caagggcct  cagatcctg  gccagaccc  caaagctag  atgagggag  tagggctgc  1020
catcttttt  ctcttcatt  gcgtcatac  gttttctag  gcagtgtac  ttgcggagg  1080
ggaagaagc  gagtcgcac  tctccagta  ccccgatgc  ttctggtgg  cggtggtgt  1140
catgaccac  gtgggatac  gtgacatgt  ccctgtgac  attggaggc  agatcgtgg  1200
ctccttgtg  gccatcgct  gtgtgctga  aattgccct  cccgtacct  tcattgtgt  1260
caatttcaa  tatttctac  accgagaaa  tgaggggga  gagcaggct  agttgctcc  1320
tgttagttc  cctaactta  cctctgaca  tgacctcag  cgccgcagc  cctctacta  1380
cagcaagtc  gagtacatg  agatcgaag  ggacatgaa  aatagcata  cccactaca  1440
gcaggctaa  atcagaact  gtaactgca  cgcaactga  caaaactgc  ttaataaga  1500
caagctcct  accgatgtt  aaaaaaagc  ccaggcaag  aatcaaaag  ccccaaaca  1560
aacccttgg  gactcctgt  ccactctgt  gatacttta  taaaaccgt  gtctttgaa  1620
gctttattt  actggcaat  cactgttgc  ttgtgaatt  ggggggtgg  caaacctga  1680
gctttcaag  tcacattta  aaaacaaaa  caaccaaac  agcaaaaag  aaaaaaaaa  1740
ccaaca  1746



<210> 3535
<211> 495
<212> PRT
<213> Rattus norvegicus
<308> P10499
<400> 3535

Met Thr Val Met Ser Gly Glu Asn Ala Asp Glu Ala Ser Ala Ala Pro 
  1               5                  10                  15
Gly His Pro Gln Asp Gly Ser Tyr Pro Arg Gln Ala Asp His Asp Asp 
             20                  25                  30
His Glu Cys Cys Glu Arg Val Val Ile Asn Ile Ser Gly Leu Arg Phe 
         35                  40                  45
Glu Thr Gln Leu Lys Thr Leu Ala Gln Phe Pro Asn Thr Leu Leu Gly 
     50                  55                  60
Asn Pro Lys Lys Arg Met Arg Tyr Phe Asp Pro Leu Arg Asn Glu Tyr 
 65                  70                  75                  80
Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr 
                 85                  90                  95
Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val Pro Leu Asp Met 
             100                105                110
Phe Ser Glu Glu Ile Lys Phe Tyr Glu Leu Gly Glu Glu Ala Met Glu 
         115                120                125
Lys Phe Arg Glu Asp Glu Gly Phe Ile Lys Glu Glu Glu Arg Pro Leu 
     130                135                140
Pro Glu Lys Glu Tyr Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr Pro 
 145                150                155                160
Glu Ser Ser Gly Pro Ala Arg Val Ile Ala Ile Val Ser Val Met Val 
                 165                170                175
Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Leu 
             180                185                190
Lys Asp Asp Lys Asp Phe Thr Gly Thr Ile His Arg Ile Asp Asn Thr 
         195                200                205
Thr Val Ile Tyr Thr Ser Asn Ile Phe Thr Asp Pro Phe Phe Ile Val 
     210                215                220
Glu Thr Leu Cys Ile Ile Trp Phe Ser Phe Glu Leu Val Val Arg Phe 
 225                230                235                240
Phe Ala Cys Pro Ser Lys Thr Asp Phe Phe Lys Asn Ile Met Asn Phe 
                 245                250                255
Ile Asp Ile Val Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu 
             260                265                270
Ile Ala Glu Gln Glu Gly Asn Gln Lys Gly Glu Gln Ala Thr Ser Leu 
         275                280                285
Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys 
     290                295                300
Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr Leu Lys 
 305                310                315                320
Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe Ile Gly 
                 325                330                335
Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Glu Glu Ala 
             340                345                350
Glu Ser His Phe Ser Ser Ile Pro Asp Ala Phe Trp Trp Ala Val Val 
         355                360                365
Ser Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Val Thr Ile Gly 
     370                375                380
Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu Thr Ile 
 385                390                395                400
Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe Tyr His 
                 405                410                415
Arg Glu Thr Glu Gly Glu Glu Gln Ala Gln Leu Leu His Val Ser Ser 
             420                425                430
Pro Asn Leu Ala Ser Asp Ser Asp Leu Ser Arg Arg Ser Ser Ser Thr 
         435                440                445
Ile Ser Lys Ser Glu Tyr Met Glu Ile Glu Glu Asp Met Asn Asn Ser 
     450                455                460
Ile Ala His Tyr Arg Gln Ala Asn Ile Arg Thr Gly Asn Cys Thr Ala 
 465                470                475                480
Thr Asp Gln Asn Cys Val Asn Lys Ser Lys Leu Leu Thr Asp Val 
                 485                490                495



<210> 3536
<211> 1488
<212> DNA
<213> Homo sapiens
<308> L02750
<400> 3536

atgacggtg  tgtctgggg  gaacgtgga  gaggcttcg  ccgccccgg  ccaccccca  60
gatggcagc  acccccgcc  ggccgacca  gacgaccac  agtgctgcg  gcgcgtggt  120
atcaacatc  ccgggctgc  cttcgagac  cagctcaag  ccctggcgc  gttccccaa  180
acgctgctg  gcaacccta  gaaacgcat  cgctacttc  accccctga  gaacgagta  240
ttcttcgac  gcaaccggc  cagcttcga  gccatcctc  actactacc  gtccggcgg  300
cgcctgcgg  ggccggtca  cgtgcccct  gacatgttc  ccgaggaga  caagtttta  360
gagttgggc  aggaggcca  ggagaagtt  cgggaggac  agggcttca  caaggagga  420
gagcgccct  tgcccgaga  ggagtacca  cgccaggtg  ggctgctct  cgagtaccc  480
gagagctcg  ggcccgcca  ggtcatcgc  atcgtctcc  tcatggtca  cctcatctc  540
atcgtcatc  tttgcctgg  gacgctccc  gagctgaag  atgacaagg  cttcacggg  600
accgtccac  gcatcgaca  caccacggt  atctacaat  ccaacatct  cacagaccc  660
ttcttcatc  tggaaacgc  gtgcatcat  tggttctcc  tcgagctgg  ggtgcgctt  720
ttcgcctgc  ccagcaaga  ggacttctt  aaaaacatc  tgaacttca  agacattgt  780
gccatcatt  cttatttca  caccctggg  accgagata  ctgagcagg  aggaaacca  840
aagggcgag  aggccacct  cctggccat  ctcagggtc  tccgcttgg  aagggtttt  900
agaatcttc  agctctccc  ccactctaa  ggcctccag  tcctgggcc  gaccctcaa  960
gctagtatg  gagagctag  gctgctcat  tttttcctc  tcatcgggg  catcctgtt  1020
tctagtgca  tgtactttg  cgaggcgga  gaagctgag  cgcacttct  cagtatccc  1080
gatgctttc  ggtgggcgg  ggtgtccat  accactgta  gatacggtg  catgtaccc  1140
gtgacaatt  gaggcaaga  cgtgggctc  ttgtgtgcc  tcgctggtg  gctaacaat  1200
gccctgccc  tacctgtca  tgtgtccaa  ttcaactat  tctaccacc  agaaactga  1260
ggggaagag  aggctcagt  gctccacgt  agttcccct  acttagcct  tgacagtga  1320
ctcagtcgc  gcagttcct  tactatgag  aagtatgag  acatggaga  cgaagagga  1380
atgaataat  gcatagccc  ttatagaca  gtcaatatc  gaactgcca  ttgcaccac  1440
gctaaccaa  actgcgtta  taagagcaa  ctactgacc  atgtttaa  1488



<210> 3537
<211> 495
<212> PRT
<213> Homo sapiens
<308> Q09470
<400> 3537

Met Thr Val Met Ser Gly Glu Asn Val Asp Glu Ala Ser Ala Ala Pro 
  1               5                  10                  15
Gly His Pro Gln Asp Gly Ser Tyr Pro Arg Gln Ala Asp His Asp Asp 
             20                  25                  30
His Glu Cys Cys Glu Arg Val Val Ile Asn Ile Ser Gly Leu Arg Phe 
         35                  40                  45
Glu Thr Gln Leu Lys Thr Leu Ala Gln Phe Pro Asn Thr Leu Leu Gly 
     50                  55                  60
Asn Pro Lys Lys Arg Met Arg Tyr Phe Asp Pro Leu Arg Asn Glu Tyr 
 65                  70                  75                  80
Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr 
                 85                  90                  95
Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val Pro Leu Asp Met 
             100                105                110
Phe Ser Glu Glu Ile Lys Phe Tyr Glu Leu Gly Glu Glu Ala Met Glu 
         115                120                125
Lys Phe Arg Glu Asp Glu Gly Phe Ile Lys Glu Glu Glu Arg Pro Leu 
     130                135                140
Pro Glu Lys Glu Tyr Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr Pro 
 145                150                155                160
Glu Ser Ser Gly Pro Ala Arg Val Ile Ala Ile Val Ser Val Met Val 
                 165                170                175
Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Leu 
             180                185                190
Lys Asp Asp Lys Asp Phe Thr Gly Thr Val His Arg Ile Asp Asn Thr 
         195                200                205
Thr Val Ile Tyr Asn Ser Asn Ile Phe Thr Asp Pro Phe Phe Ile Val 
     210                215                220
Glu Thr Leu Cys Ile Ile Trp Phe Ser Phe Glu Leu Val Val Arg Phe 
 225                230                235                240
Phe Ala Cys Pro Ser Lys Thr Asp Phe Phe Lys Asn Ile Met Asn Phe 
                 245                250                255
Ile Asp Ile Val Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu 
             260                265                270
Ile Ala Glu Gln Glu Gly Asn Gln Lys Gly Glu Gln Ala Thr Ser Leu 
         275                280                285
Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys 
     290                295                300
Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr Leu Lys 
 305                310                315                320
Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe Ile Gly 
                 325                330                335
Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Glu Glu Ala 
             340                345                350
Glu Ser His Phe Ser Ser Ile Pro Asp Ala Phe Trp Trp Ala Val Val 
         355                360                365
Ser Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Val Thr Ile Gly 
     370                375                380
Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu Thr Ile 
 385                390                395                400
Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe Tyr His 
                 405                410                415
Arg Glu Thr Glu Gly Glu Glu Gln Ala Gln Leu Leu His Val Ser Ser 
             420                425                430
Pro Asn Leu Ala Ser Asp Ser Asp Leu Ser Arg Arg Ser Ser Ser Thr 
         435                440                445
Met Ser Lys Tyr Glu Tyr Met Glu Ile Glu Glu Asp Met Asn Asn Ser 
     450                455                460
Ile Ala His Tyr Arg Gln Val Asn Ile Arg Thr Ala Asn Cys Thr Thr 
 465                470                475                480
Ala Asn Gln Asn Cys Val Asn Lys Ser Lys Leu Leu Thr Asp Val 
                 485                490                495



<210> 3538
<211> 1746
<212> DNA
<213> Rattus norvegicus
<308> M26161
<400> 3538

tcctggcct  ctacccctg  accctgcat  catcatgac  gtgatgtca  gggagaatg  60
agacgaggc  tcggccgct  caggtcacc  ccaggatgg  agctaccca  ggcaggcgg  120
ccacgacga  cacgaatgc  gcgagcgcg  ggtgatcaa  atctccggg  tgcgcttcg  180
gacgcagct  aagactctg  cccagttcc  caacacgct  ctgggcaac  cgaagaaac  240
catgcgcta  tttgaccct  tgaggaatg  gtacttctt  gaccgcaac  ggcccagct  300
cgatgccat  ctttattac  accagtcgg  ggggcgcct  cgcaggccg  tcaacgtgc  360
cctggacat  ttctccgag  agattaaat  ttacgagtt  ggcgaggag  ccatggaga  420
gttccggga  gatgagggc  tcatcaagg  agaggagcg  cccctaccc  agaaggagt  480
ccagcgcca  gtgtggctg  tctttgagt  tccggagag  tcaggacct  cacgggtta  540
tgccattgt  tccgtcatg  tcatcctca  ctccatagt  atcttttgc  tggagactc  600
ccctgagct  aaggatgac  aggacttca  gggcaccat  caccgcatc  ataacacca  660
agtcatcta  acttctaac  tcttcacag  ccctttctt  attgtggaa  ccttgtgta  720
catctggtt  tcttttgag  tggtggtgc  cttcttcgc  tgccccagc  agacagact  780
ctttaagaa  atcatgaac  tcatcgaca  tgtggccat  atcccttat  tcattaccc  840
gggcacaga  atagctgag  aggagggga  tcagaaggg  gagcaggcc  cttccctgg  900
catcctcag  gtcatccgc  tggtaaggg  gttcagaat  ttcaaactc  cccgccact  960
caagggcct  cagatcctg  gccagaccc  caaagctag  atgagggag  tagggctgc  1020
catcttttt  ctcttcatt  gcgtcatac  gttttctag  gcagtgtac  ttgcggagg  1080
ggaagaagc  gagtcgcac  tctccagta  ccccgatgc  ttctggtgg  cggtggtgt  1140
catgaccac  gtgggatac  gtgacatgt  ccctgtgac  attggaggc  agatcgtgg  1200
ctccttgtg  gccatcgct  gtgtgctga  aattgccct  cccgtacct  tcattgtgt  1260
caatttcaa  tatttctac  accgagaaa  tgaggggga  gagcaggct  agttgctcc  1320
tgttagttc  cctaactta  cctctgaca  tgacctcag  cgccgcagc  cctctacta  1380
cagcaagtc  gagtacatg  agatcgaag  ggacatgaa  aatagcata  cccactaca  1440
gcaggctaa  atcagaact  gtaactgca  cgcaactga  caaaactgc  ttaataaga  1500
caagctcct  accgatgtt  aaaaaaagc  ccaggcaag  aatcaaaag  ccccaaaca  1560
aacccttgg  gactcctgt  ccactctgt  gatacttta  taaaaccgt  gtctttgaa  1620
gctttattt  actggcaat  cactgttgc  ttgtgaatt  ggggggtgg  caaacctga  1680
gctttcaag  tcacattta  aaaacaaaa  caaccaaac  agcaaaaag  aaaaaaaaa  1740
ccaaca  1746



<210> 3539
<211> 495
<212> PRT
<213> Rattus norvegicus
<308> P10499
<400> 3539

Met Thr Val Met Ser Gly Glu Asn Ala Asp Glu Ala Ser Ala Ala Pro 
  1               5                  10                  15
Gly His Pro Gln Asp Gly Ser Tyr Pro Arg Gln Ala Asp His Asp Asp 
             20                  25                  30
His Glu Cys Cys Glu Arg Val Val Ile Asn Ile Ser Gly Leu Arg Phe 
         35                  40                  45
Glu Thr Gln Leu Lys Thr Leu Ala Gln Phe Pro Asn Thr Leu Leu Gly 
     50                  55                  60
Asn Pro Lys Lys Arg Met Arg Tyr Phe Asp Pro Leu Arg Asn Glu Tyr 
 65                  70                  75                  80
Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr 
                 85                  90                  95
Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val Pro Leu Asp Met 
             100                105                110
Phe Ser Glu Glu Ile Lys Phe Tyr Glu Leu Gly Glu Glu Ala Met Glu 
         115                120                125
Lys Phe Arg Glu Asp Glu Gly Phe Ile Lys Glu Glu Glu Arg Pro Leu 
     130                135                140
Pro Glu Lys Glu Tyr Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr Pro 
 145                150                155                160
Glu Ser Ser Gly Pro Ala Arg Val Ile Ala Ile Val Ser Val Met Val 
                 165                170                175
Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Leu 
             180                185                190
Lys Asp Asp Lys Asp Phe Thr Gly Thr Ile His Arg Ile Asp Asn Thr 
         195                200                205
Thr Val Ile Tyr Thr Ser Asn Ile Phe Thr Asp Pro Phe Phe Ile Val 
     210                215                220
Glu Thr Leu Cys Ile Ile Trp Phe Ser Phe Glu Leu Val Val Arg Phe 
 225                230                235                240
Phe Ala Cys Pro Ser Lys Thr Asp Phe Phe Lys Asn Ile Met Asn Phe 
                 245                250                255
Ile Asp Ile Val Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu 
             260                265                270
Ile Ala Glu Gln Glu Gly Asn Gln Lys Gly Glu Gln Ala Thr Ser Leu 
         275                280                285
Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys 
     290                295                300
Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr Leu Lys 
 305                310                315                320
Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe Ile Gly 
                 325                330                335
Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Glu Glu Ala 
             340                345                350
Glu Ser His Phe Ser Ser Ile Pro Asp Ala Phe Trp Trp Ala Val Val 
         355                360                365
Ser Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Val Thr Ile Gly 
     370                375                380
Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu Thr Ile 
 385                390                395                400
Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe Tyr His 
                 405                410                415
Arg Glu Thr Glu Gly Glu Glu Gln Ala Gln Leu Leu His Val Ser Ser 
             420                425                430
Pro Asn Leu Ala Ser Asp Ser Asp Leu Ser Arg Arg Ser Ser Ser Thr 
         435                440                445
Ile Ser Lys Ser Glu Tyr Met Glu Ile Glu Glu Asp Met Asn Asn Ser 
     450                455                460
Ile Ala His Tyr Arg Gln Ala Asn Ile Arg Thr Gly Asn Cys Thr Ala 
 465                470                475                480
Thr Asp Gln Asn Cys Val Asn Lys Ser Lys Leu Leu Thr Asp Val 
                 485                490                495



<210> 3540
<211> 1488
<212> DNA
<213> Homo sapiens
<308> L02750
<400> 3540

atgacggtg  tgtctgggg  gaacgtgga  gaggcttcg  ccgccccgg  ccaccccca  60
gatggcagc  acccccgcc  ggccgacca  gacgaccac  agtgctgcg  gcgcgtggt  120
atcaacatc  ccgggctgc  cttcgagac  cagctcaag  ccctggcgc  gttccccaa  180
acgctgctg  gcaacccta  gaaacgcat  cgctacttc  accccctga  gaacgagta  240
ttcttcgac  gcaaccggc  cagcttcga  gccatcctc  actactacc  gtccggcgg  300
cgcctgcgg  ggccggtca  cgtgcccct  gacatgttc  ccgaggaga  caagtttta  360
gagttgggc  aggaggcca  ggagaagtt  cgggaggac  agggcttca  caaggagga  420
gagcgccct  tgcccgaga  ggagtacca  cgccaggtg  ggctgctct  cgagtaccc  480
gagagctcg  ggcccgcca  ggtcatcgc  atcgtctcc  tcatggtca  cctcatctc  540
atcgtcatc  tttgcctgg  gacgctccc  gagctgaag  atgacaagg  cttcacggg  600
accgtccac  gcatcgaca  caccacggt  atctacaat  ccaacatct  cacagaccc  660
ttcttcatc  tggaaacgc  gtgcatcat  tggttctcc  tcgagctgg  ggtgcgctt  720
ttcgcctgc  ccagcaaga  ggacttctt  aaaaacatc  tgaacttca  agacattgt  780
gccatcatt  cttatttca  caccctggg  accgagata  ctgagcagg  aggaaacca  840
aagggcgag  aggccacct  cctggccat  ctcagggtc  tccgcttgg  aagggtttt  900
agaatcttc  agctctccc  ccactctaa  ggcctccag  tcctgggcc  gaccctcaa  960
gctagtatg  gagagctag  gctgctcat  tttttcctc  tcatcgggg  catcctgtt  1020
tctagtgca  tgtactttg  cgaggcgga  gaagctgag  cgcacttct  cagtatccc  1080
gatgctttc  ggtgggcgg  ggtgtccat  accactgta  gatacggtg  catgtaccc  1140
gtgacaatt  gaggcaaga  cgtgggctc  ttgtgtgcc  tcgctggtg  gctaacaat  1200
gccctgccc  tacctgtca  tgtgtccaa  ttcaactat  tctaccacc  agaaactga  1260
ggggaagag  aggctcagt  gctccacgt  agttcccct  acttagcct  tgacagtga  1320
ctcagtcgc  gcagttcct  tactatgag  aagtatgag  acatggaga  cgaagagga  1380
atgaataat  gcatagccc  ttatagaca  gtcaatatc  gaactgcca  ttgcaccac  1440
gctaaccaa  actgcgtta  taagagcaa  ctactgacc  atgtttaa  1488



<210> 3541
<211> 495
<212> PRT
<213> Homo sapiens
<308> Q09470
<400> 3541

Met Thr Val Met Ser Gly Glu Asn Val Asp Glu Ala Ser Ala Ala Pro 
  1               5                  10                  15
Gly His Pro Gln Asp Gly Ser Tyr Pro Arg Gln Ala Asp His Asp Asp 
             20                  25                  30
His Glu Cys Cys Glu Arg Val Val Ile Asn Ile Ser Gly Leu Arg Phe 
         35                  40                  45
Glu Thr Gln Leu Lys Thr Leu Ala Gln Phe Pro Asn Thr Leu Leu Gly 
     50                  55                  60
Asn Pro Lys Lys Arg Met Arg Tyr Phe Asp Pro Leu Arg Asn Glu Tyr 
 65                  70                  75                  80
Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr 
                 85                  90                  95
Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val Pro Leu Asp Met 
             100                105                110
Phe Ser Glu Glu Ile Lys Phe Tyr Glu Leu Gly Glu Glu Ala Met Glu 
         115                120                125
Lys Phe Arg Glu Asp Glu Gly Phe Ile Lys Glu Glu Glu Arg Pro Leu 
     130                135                140
Pro Glu Lys Glu Tyr Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr Pro 
 145                150                155                160
Glu Ser Ser Gly Pro Ala Arg Val Ile Ala Ile Val Ser Val Met Val 
                 165                170                175
Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Leu 
             180                185                190
Lys Asp Asp Lys Asp Phe Thr Gly Thr Val His Arg Ile Asp Asn Thr 
         195                200                205
Thr Val Ile Tyr Asn Ser Asn Ile Phe Thr Asp Pro Phe Phe Ile Val 
     210                215                220
Glu Thr Leu Cys Ile Ile Trp Phe Ser Phe Glu Leu Val Val Arg Phe 
 225                230                235                240
Phe Ala Cys Pro Ser Lys Thr Asp Phe Phe Lys Asn Ile Met Asn Phe 
                 245                250                255
Ile Asp Ile Val Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu 
             260                265                270
Ile Ala Glu Gln Glu Gly Asn Gln Lys Gly Glu Gln Ala Thr Ser Leu 
         275                280                285
Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys 
     290                295                300
Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr Leu Lys 
 305                310                315                320
Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe Ile Gly 
                 325                330                335
Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Glu Glu Ala 
             340                345                350
Glu Ser His Phe Ser Ser Ile Pro Asp Ala Phe Trp Trp Ala Val Val 
         355                360                365
Ser Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Val Thr Ile Gly 
     370                375                380
Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu Thr Ile 
 385                390                395                400
Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe Tyr His 
                 405                410                415
Arg Glu Thr Glu Gly Glu Glu Gln Ala Gln Leu Leu His Val Ser Ser 
             420                425                430
Pro Asn Leu Ala Ser Asp Ser Asp Leu Ser Arg Arg Ser Ser Ser Thr 
         435                440                445
Met Ser Lys Tyr Glu Tyr Met Glu Ile Glu Glu Asp Met Asn Asn Ser 
     450                455                460
Ile Ala His Tyr Arg Gln Val Asn Ile Arg Thr Ala Asn Cys Thr Thr 
 465                470                475                480
Ala Asn Gln Asn Cys Val Asn Lys Ser Lys Leu Leu Thr Asp Val 
                 485                490                495



<210> 3542
<211> 846
<212> DNA
<213> Rattus norvegicus
<308> M26247
<400> 3542

agagtttct  ttgcctaca  ttctaaaaa  atcacccgt  ctgagactg  tttttctaa  60
accgactat  gaaattcca  tgaattaat  ctggatgac  tcaccaaca  caccattct  120
gataacctc  ctgaaaata  tgaaccaat  aatgacttc  ctcgagttg  tggtggaga  180
aatgcgaaa  caggtcaaa  cccttggca  gtcattcta  atggtgaaa  tgaggcatt  240
tgtggaggc  ccatcatta  tgaaaaatg  attgtaact  ctgcccact  tcttaaacc  300
ggtgataaa  ttgaggttg  tgctggtga  cataatatt  atgagaagg  agacacaga  360
caaaggaga  atgtgattc  aactatccc  catcaccag  acaatgcaa  tattaataa  420
tatagtcat  acattgcct  gctggaact  gataaacct  taatactaa  cagctatgt  480
acacctatc  gtgttgcca  taaggaata  acaaatatc  tcctcaagt  tggttctgg  540
tatgtgagt  gctggggga  agtcttcaa  aaagggaga  aggcttcca  tcttcagta  600
cttagagtt  cactggttg  ccgagccac  tgccttagg  ccacaaaat  cagcatcta  660
aacaacatg  tctgtgcag  ttaccgtga  ggaggcaaa  attcatgtg  aggagatag  720
gggggaccc  atgttactg  agtagaagg  acaagtttc  taactggca  tattagctg  780
ggtgaagaa  gtgcaatga  aggcaaata  ggaatatat  ctaaggttt  caggtatgt  840
aactgg  846



<210> 3543
<211> 282
<212> PRT
<213> Rattus norvegicus
<308> AAA41162
<400> 3543

Arg Val Ser Val Ala Tyr Asn Ser Lys Lys Ile Thr Arg Ala Glu Thr 
  1               5                  10                  15
Val Phe Ser Asn Thr Asp Tyr Gly Asn Ser Thr Glu Leu Ile Leu Asp 
             20                  25                  30
Asp Ile Thr Asn Ser Thr Ile Leu Asp Asn Leu Thr Glu Asn Ser Glu 
         35                  40                  45
Pro Ile Asn Asp Phe Thr Arg Val Val Gly Gly Glu Asn Ala Lys Pro 
     50                  55                  60
Gly Gln Ile Pro Trp Gln Val Ile Leu Asn Gly Glu Ile Glu Ala Phe 
 65                  70                  75                  80
Cys Gly Gly Ala Ile Ile Asn Glu Lys Trp Ile Val Thr Ala Ala His 
                 85                  90                  95
Cys Leu Lys Pro Gly Asp Lys Ile Glu Val Val Ala Gly Glu His Asn 
             100                105                110
Ile Asp Glu Lys Glu Asp Thr Glu Gln Arg Arg Asn Val Ile Arg Thr 
         115                120                125
Ile Pro His His Gln Tyr Asn Ala Thr Ile Asn Lys Tyr Ser His Asp 
     130                135                140
Ile Ala Leu Leu Glu Leu Asp Lys Pro Leu Ile Leu Asn Ser Tyr Val 
 145                150                155                160
Thr Pro Ile Cys Val Ala Asn Lys Glu Tyr Thr Asn Ile Phe Leu Lys 
                 165                170                175
Phe Gly Ser Gly Tyr Val Ser Gly Trp Gly Lys Val Phe Asn Lys Gly 
             180                185                190
Arg Gln Ala Ser Ile Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg 
         195                200                205
Ala Thr Cys Leu Arg Ser Thr Lys Phe Ser Ile Tyr Asn Asn Met Phe 
     210                215                220
Cys Ala Gly Tyr Arg Glu Gly Gly Lys Asp Ser Cys Glu Gly Asp Ser 
 225                230                235                240
Gly Gly Pro His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly 
                 245                250                255
Ile Ile Ser Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile 
             260                265                270
Tyr Thr Lys Val Ser Arg Tyr Val Asn Trp 
         275                280



<210> 3544
<211> 2804
<212> DNA
<213> Homo sapiens
<308> NM_000133
<400> 3544

accactttc  caatctgct  gcaaaggtt  tgcagcgcg  gaacatgat  atggcagaa  60
caccaggcc  catcaccat  tgcctttta  gatatctac  cagtgctga  tgtacagtt  120
ttcttgatc  tgaaaacgc  aacaaaatt  tgaatcggc  aaagaggta  aattcaggt  180
aattggaag  gtttgttca  gggaacctt  agagagaat  tatggaaga  aagtgtagt  240
ttgaagaag  acgagaagt  tttgaaaac  ctgaaagaa  aactgaatt  tggaagcag  300
atgttgatg  agatcagtg  gagtccaat  catgtttaa  tggcggcag  tgcaaggat  360
acattaatt  ctatgaatg  tggtgtccc  ttggatttg  aggaaagaa  tgtgaatta  420
atgtaacat  taacattaa  aatggcaga  gcgagcagt  ttgtaaaaa  agtgctgat  480
acaaggtgg  ttgctcctg  actgaggga  atcgacttg  agaaaacca  aagtcctgt  540
aaccagcag  gccatttcc  tgtggaaga  tttctgttt  acaaacttc  aagctcacc  600
gtgctgaga  tgtttttcc  gatgtggac  atgtaaatt  tactgaagc  gaaaccatt  660
tggataaca  cactcaaag  acccaatca  ttaatgact  cactcgggt  gttggtgga  720
aagatgcca  accaggtca  ttcccttgg  aggttgttt  gaatggtaa  gttgatgca  780
tctgtggag  ctctatcgt  aatgaaaaa  ggattgtaa  tgctgccca  tgtgttgaa  840
ctggtgtta  aattacagt  gtcgcaggt  aacataata  tgaggagac  gaacataca  900
agcaaaagc  aaatgtgat  cgaattatt  ctcaccaca  ctacaatgc  gctattaat  960
agtacaacc  tgacattgc  cttctggaa  tggacgaac  cttagtgct  aacagctac  1020
ttacaccta  ttgcattgc  gacaaggaa  acacgaaca  cttcctcaa  tttggatct  1080
gctatgtaa  tggctgggg  agagtcttc  acaaaggga  atcagcttt  gttcttcag  1140
accttagag  tccacttgt  gaccgagcc  catgtcttc  atctacaaa  ttcaccatc  1200
ataacaaca  gttctgtgc  ggcttccat  aaggaggta  agattcatg  caaggagat  1260
gtgggggac  ccatgttac  gaagtggaa  ggaccagtt  cttaactgg  attattagc  1320
ggggtgaag  gtgtgcaat  aaaggcaaa  atggaatat  taccaaggt  tcccggtat  1380
tcaactgga  taaggaaaa  acaaagctc  cttaatgaa  gatggattt  caaggttaa  1440
tcattggaa  tgaaaatta  cagggcctc  cactaacta  tcactttcc  atcttttgt  1500
agatttgaa  atatacatt  tatgatcat  gctttttct  tttacaggg  agaatttca  1560
attttacct  agcaaattg  ttagaaaat  gaaccacta  aggaatata  tgtgttagg  1620
aattacagt  atttctaag  gcccagccc  tgacaaaat  gtgaagtta  attctccac  1680
ctgtccatc  gatactatg  ttctccact  tggcaacta  ctcactcaa  tttccctcc  1740
tagcagcat  ccatcttcc  gatcttctt  gcttctcca  ccaaaacat  aatgtttat  1800
agttctgta  acagtacag  atctttggt  tactctatc  caaggccag  accacactc  1860
tgaagaaag  acacaggag  agctgagag  ctaaaactc  tcaaaaaca  tactccttt  1920
cctctaccc  attcctcaa  cttttacct  ttccaaatc  caatcccca  atcagtttt  1980
ctctttctt  ctccctctc  cccttttac  ctccatggt  gttaaagga  agatgggga  2040
catcattct  ttatacttc  gtacacagt  atacatgtc  atcaaaccc  gacttgctt  2100
catagtgga  acttgcttt  cagaacata  ggatgaagt  aggtgcctg  aaagtttgg  2160
ggaaaagtt  ctttcagag  gttaagtta  tttatatat  taatatata  ataaaatat  2220
taatataca  tataaatat  tagtgtgtg  gtgtatgcg  gtgtgtaga  acacacgca  2280
acacacata  aatggaagc  ataagccat  ctaagagct  gtatggtta  ggaggtctg  2340
ctaggcatg  tttcacgaa  gcaagattg  catatcatt  taactaaaa  agctgacat  2400
gacccagac  tattgtact  tttctaaaa  taataataa  aatgctaac  gaaagaaga  2460
aaccgttcg  ttgcaatct  cagctagta  agactttga  gaagaattc  acagtgtgt  2520
ttcagcagt  ttcagagcc  agcaagaag  tgaagttgc  tagaccaga  gacataagt  2580
tcatgtctc  tttaactag  ataccccga  gtggagaag  gtgcagcag  ctcaaaggc  2640
taagtcatt  caatcagcc  actaagttg  ccttttctg  tttcgtgtt  accatggaa  2700
attttgatt  tagttaatc  ttctatctt  aatcttcta  agagttgct  accaactga  2760
gtatgtttc  ctttgtgaa  taataaact  gtgttctgg  tcat  2804



<210> 3545
<211> 461
<212> PRT
<213> Homo sapiens
<308> P00740
<400> 3545

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
  1               5                  10                  15
Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
             20                  25                  30
Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
         35                  40                  45
Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
     50                  55                  60
Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
 65                  70                  75                  80
Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                 85                  90                  95
Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
             100                105                110
Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
         115                120                125
Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
     130                135                140
Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
 145                150                155                160
Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                 165                170                175
Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
             180                185                190
Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
         195                200                205
Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
     210                215                220
Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
 225                230                235                240
Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                 245                250                255
Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
             260                265                270
Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
         275                280                285
His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
     290                295                300
Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
 305                310                315                320
Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                 325                330                335
Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
             340                345                350
Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
         355                360                365
Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
     370                375                380
Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
 385                390                395                400
Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                 405                410                415
Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
             420                425                430
Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
         435                440                445
Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
     450                455                460



<210> 3546
<211> 521
<212> DNA
<213> Rattus norvegicus
<308> M26594
<400> 3546

tttttagat  gtgcaagat  catacaaag  aaagatggc  actgtttat  ctgaacccc  60
aaacaaaga  gaatttgtc  cctcccaga  gtacagcac  aattatgac  agatcctac  120
tgattgtta  tcgtggcct  aagaagttc  agaaaatac  gaccaaagt  aatcagtaa  180
acaacagct  gaattttta  ctttattaa  aagatcttg  agttttcag  gatttttaa  240
agtcagaat  ttttgtgat  attcacagt  tgcttagaa  aaggtgatt  ttgtttagc  300
cacagactc  tgggagtag  ttagtgtaa  ttaggatga  cttcaccct  gacaggttt  360
tttcactta  tgtggcagt  tatgttttc  ctgtgatta  tctctttac  aattctgtt  420
aaaagctac  gtacctgct  ctgagaaag  cctcactgc  atgtaggaa  ctaatggaa  480
acccacact  gtaataaat  aatatagca  aacttgatt  c  521



<210> 3547
<211> 572
<212> PRT
<213> Rattus norvegicus
<308> AAA41563
<400> 3547

Met Asp Pro Arg Ala Pro Arg Arg Arg His Thr His Gln Arg Gly Tyr 
  1               5                  10                  15
Leu Leu Thr Arg Asp Pro His Leu Asn Lys Asp Leu Ala Phe Thr Leu 
             20                  25                  30
Glu Glu Arg Gln Gln Leu Lys Ile His Gly Leu Leu Pro Pro Cys Ile 
         35                  40                  45
Val Asn Gln Glu Ile Gln Val Leu Arg Val Ile Lys Asn Phe Glu Arg 
     50                  55                  60
Leu Asn Ser Asp Phe Asp Arg Tyr Leu Leu Leu Met Asp Leu Gln Asp 
 65                  70                  75                  80
Arg Asn Glu Lys Leu Phe Tyr Ser Val Leu Met Ser Asn Val Glu Lys 
                 85                  90                  95
Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Gln Gln 
             100                105                110
Tyr Ser Leu Ala Phe Arg Lys Pro Arg Gly Leu Phe Ile Ser Ile His 
         115                120                125
Asp Lys Gly His Ile Ala Ser Val Leu Asn Ala Trp Pro Glu Asp Val 
     130                135                140
Val Lys Ala Ile Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly 
 145                150                155                160
Asp Leu Gly Cys Asn Gly Met Gly Ile Pro Val Gly Lys Leu Ala Leu 
                 165                170                175
Tyr Thr Ala Cys Gly Gly Val Asn Pro Gln Gln Cys Leu Pro Ile Thr 
             180                185                190
Leu Asp Val Gly Thr Glu Asn Glu Glu Leu Leu Lys Asp Pro Leu Tyr 
         195                200                205
Ile Gly Leu Arg His Arg Arg Val Arg Gly Pro Glu Tyr Asp Ala Phe 
     210                215                220
Leu Asp Glu Phe Met Glu Ala Ala Ser Ser Lys Tyr Gly Met Asn Cys 
 225                230                235                240
Leu Ile Gln Phe Glu Asp Phe Ala Asn Leu Asn Ala Phe Arg Leu Leu 
                 245                250                255
Asn Lys Tyr Arg Asn Lys Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly 
             260                265                270
Thr Ala Ser Val Ala Val Ala Gly Leu Leu Ala Ala Leu Arg Ile Thr 
         275                280                285
Lys Asn Lys Leu Ser Asp Gln Thr Val Leu Phe Gln Gly Ala Gly Glu 
     290                295                300
Ala Ala Leu Gly Ile Ala His Leu Ile Val Met Ala Met Glu Lys Glu 
 305                310                315                320
Gly Leu Ser Lys Glu Lys Ala Arg Gln Lys Ile Trp Leu Val Asp Ser 
                 325                330                335
Lys Gly Leu Ile Val Lys Gly Arg Ala Ser Leu Thr Glu Glu Lys Glu 
             340                345                350
Val Phe Ala His Glu His Glu Glu Met Lys Asn Leu Glu Ala Ile Val 
         355                360                365
Gln Lys Ile Lys Pro Thr Ala Leu Ile Gly Val Ala Ala Ile Gly Gly 
     370                375                380
Ala Phe Thr Glu Gln Ile Leu Lys Asp Met Ala Ala Phe Asn Glu Arg 
 385                390                395                400
Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala Glu Cys Ser 
                 405                410                415
Ala Glu Glu Cys Tyr Lys Val Thr Lys Gly Arg Ala Ile Phe Ala Ser 
             420                425                430
Gly Ser Pro Phe Asp Pro Val Thr Leu Pro Asp Gly Arg Thr Leu Phe 
         435                440                445
Pro Gly Gln Gly Asn Asn Ser Tyr Val Phe Pro Gly Val Ala Leu Gly 
     450                455                460
Val Val Ala Cys Gly Leu Arg His Ile Asn Asp Ser Val Phe Leu Thr 
 465                470                475                480
Thr Ala Glu Val Ile Ser Gln Gln Val Ser Asp Lys His Leu Glu Glu 
                 485                490                495
Gly Arg Leu Tyr Pro Pro Leu Asn Thr Ile Arg Asp Val Ser Leu Lys 
             500                505                510
Ile Ala Val Lys Ile Val Gln Asp Ala Tyr Lys Glu Lys Met Ala Thr 
         515                520                525
Val Tyr Pro Glu Pro Gln Asn Lys Glu Glu Phe Val Ser Ser Gln Met 
     530                535                540
Tyr Ser Thr Asn Tyr Asp Gln Ile Leu Pro Asp Cys Tyr Ser Trp Pro 
 545                550                555                560
Glu Glu Val Gln Lys Ile Gln Thr Lys Val Asn Gln 
                 565                570



<210> 3548
<211> 1838
<212> DNA
<213> Homo sapiens
<308> L34035
<400> 3548

ccggcgcca  ccatggagc  cgaagcccc  cgtcgccgc  acacccatc  gcgcggcta  60
ctgctgaca  ggaaccctc  cctcaacaa  gacttggcc  ttaccctgg  agagagaca  120
caattgaac  ttcatggat  gttgccacc  tccttcaac  gtcaggaga  ccaggttct  180
agagtagta  aaaatttcg  gcatctgaa  tctgacttt  acaggtatc  tctcttaat  240
gatctccaa  atagaaatg  aaaactctt  tatagagtg  tgacatctg  cattgagaa  300
ttcatgcct  ttgtttata  tcccactgt  ggtctggct  gccaacaat  tagtttggt  360
tttcggaag  caagaggtc  ctttattac  atccacgat  gagggcata  tgcttcagt  420
ctcaatgca  ggccagaag  tgtcatcaa  gccattgtg  tgactgatg  agagcgtat  480
cttggcttg  gagaccttg  ctgtaatgg  atgggcatc  ctgtgggta  attggctct  540
tatacagct  gcggaggga  gaatcctca  gaatgtctg  ctgtcattc  ggatgtggg  600
accgaaaat  aggagttac  taaagatcc  ctctacatt  gactacggc  gagaagagt  660
agaggttct  aatatgatg  ttttttgga  gaattcatg  aggcagttt  ttccaagta  720
ggcatgaat  gccttattc  gtttgaaga  tttgccaat  tgaatgcat  tcgtctcct  780
aacaagtat  gaaaccagt  ttgcacatt  aatgatgat  ttcaaggaa  agcatctgt  840
gcagttgca  gtctccttg  agctcttcg  ataaccaag  acaaactgt  tgatcaaac  900
atactattc  aaggagctg  agaggctgc  ctagggatt  cacacctga  tgtgatggc  960
ttggaaaaa  aaggtttac  aaaggagaa  gccatcaaa  agatatggc  ggttgattc  1020
aaaggatta  tagttaagg  acgtgcttc  ttaacacaa  agaaagaga  gtttgccca  1080
gaacatgaa  aaatgaaga  cctagaagc  attgttcaa  aaataaaac  aactgccct  1140
ataggagtt  ctgcaattg  tggtgcatt  tcagaacaa  ttctcaaag  tatggctgc  1200
ttcaatgaa  ggcctatta  ttttgcttt  agtaatcca  ctagcaaag  agaatgttc  1260
gcagagcag  gctacaaaa  aaccaaggg  cgtgcaatt  ttgccagtg  cagtccttt  1320
gatccagtc  ctctcccag  tggacggac  ctgtttcct  gccaaggca  caattccta  1380
gtgttccct  gagttgctc  tggggtggt  gcctgcgga  tgagacaca  cgatgataa  1440
gtcttcctc  ccactgctg  ggtcatatc  cagcaagtg  cagataaac  cctgcaaga  1500
ggccggctc  atcctcctt  gaataccat  cgagacgtt  cgttgaaaa  tgcagtaaa  1560
attgtgcaa  atgcataca  agaaaagat  gccactgtt  atcctgaac  ccaaaacaa  1620
gaagaattt  tctcctccc  gatgtacag  actaattat  accagatcc  acctgattg  1680
tatccgtgg  ctgcagaag  ccagaaaat  cagaccaaa  tcaaccagt  acgcaacag  1740
taggatttt  aactttatt  gtaaaatct  gaagttttc  tgatcttta  gggtcagaa  1800
cttttatga  gattcatag  atgcttaga  taaggtgc  1838



<210> 3549
<211> 572
<212> PRT
<213> Homo sapiens
<308> P48163
<400> 3549

Met Glu Pro Glu Ala Pro Arg Arg Arg His Thr His Gln Arg Gly Tyr 
  1               5                  10                  15
Leu Leu Thr Arg Asn Pro His Leu Asn Lys Asp Leu Ala Phe Thr Leu 
             20                  25                  30
Glu Glu Arg Gln Gln Leu Asn Ile His Gly Leu Leu Pro Pro Ser Phe 
         35                  40                  45
Asn Ser Gln Glu Ile Gln Val Leu Arg Val Val Lys Asn Phe Glu His 
     50                  55                  60
Leu Asn Ser Asp Phe Asp Arg Tyr Leu Leu Leu Met Asp Leu Gln Asp 
 65                  70                  75                  80
Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr Ser Asp Ile Glu Lys 
                 85                  90                  95
Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Gln Gln 
             100                105                110
Tyr Ser Leu Val Phe Arg Lys Pro Arg Gly Leu Phe Ile Thr Ile His 
         115                120                125
Asp Arg Gly His Ile Ala Ser Val Leu Asn Ala Trp Pro Glu Asp Val 
     130                135                140
Ile Lys Ala Ile Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly 
 145                150                155                160
Asp Leu Gly Cys Asn Gly Met Gly Ile Pro Val Gly Lys Leu Ala Leu 
                 165                170                175
Tyr Thr Ala Cys Gly Gly Met Asn Pro Gln Glu Cys Leu Pro Val Ile 
             180                185                190
Leu Asp Val Gly Thr Glu Asn Glu Glu Leu Leu Lys Asp Pro Leu Tyr 
         195                200                205
Ile Gly Leu Arg Gln Arg Arg Val Arg Gly Ser Glu Tyr Asp Asp Phe 
     210                215                220
Leu Asp Glu Phe Met Glu Ala Val Ser Ser Lys Tyr Gly Met Asn Cys 
 225                230                235                240
Leu Ile Gln Phe Glu Asp Phe Ala Asn Val Asn Ala Phe Arg Leu Leu 
                 245                250                255
Asn Lys Tyr Arg Asn Gln Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly 
             260                265                270
Thr Ala Ser Val Ala Val Ala Gly Leu Leu Ala Ala Leu Arg Ile Thr 
         275                280                285
Lys Asn Lys Leu Ser Asp Gln Thr Ile Leu Phe Gln Gly Ala Gly Glu 
     290                295                300
Ala Ala Leu Gly Ile Ala His Leu Ile Val Met Ala Leu Glu Lys Glu 
 305                310                315                320
Gly Leu Pro Lys Glu Lys Ala Ile Lys Lys Ile Trp Leu Val Asp Ser 
                 325                330                335
Lys Gly Leu Ile Val Lys Gly Arg Ala Ser Leu Thr Gln Glu Lys Glu 
             340                345                350
Lys Phe Ala His Glu His Glu Glu Met Lys Asn Leu Glu Ala Ile Val 
         355                360                365
Gln Glu Ile Lys Pro Thr Ala Leu Ile Gly Val Ala Ala Ile Gly Gly 
     370                375                380
Ala Phe Ser Glu Gln Ile Leu Lys Asp Met Ala Ala Phe Asn Glu Arg 
 385                390                395                400
Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala Glu Cys Ser 
                 405                410                415
Ala Glu Gln Cys Tyr Lys Ile Thr Lys Gly Arg Ala Ile Phe Ala Ser 
             420                425                430
Gly Ser Pro Phe Asp Pro Val Thr Leu Pro Asn Gly Gln Thr Leu Tyr 
         435                440                445
Pro Gly Gln Gly Asn Asn Ser Tyr Val Phe Pro Gly Val Ala Leu Gly 
     450                455                460
Val Val Ala Cys Gly Leu Arg Gln Ile Thr Asp Asn Ile Phe Leu Thr 
 465                470                475                480
Thr Ala Glu Val Ile Ala Gln Gln Val Ser Asp Lys His Leu Glu Glu 
                 485                490                495
Gly Arg Leu Tyr Pro Pro Leu Asn Thr Ile Arg Asp Val Ser Leu Lys 
             500                505                510
Ile Ala Glu Lys Ile Val Lys Asp Ala Tyr Gln Glu Lys Thr Ala Thr 
         515                520                525
Val Tyr Pro Glu Pro Gln Asn Lys Glu Ala Phe Val Arg Ser Gln Met 
     530                535                540
Tyr Ser Thr Asp Tyr Asp Gln Ile Leu Pro Asp Cys Tyr Ser Trp Pro 
 545                550                555                560
Glu Glu Val Gln Lys Ile Gln Thr Lys Val Asp Gln 
                 565                570



<210> 3550
<211> 521
<212> DNA
<213> Rattus norvegicus
<308> M26594
<400> 3550

tttttagat  gtgcaagat  catacaaag  aaagatggc  actgtttat  ctgaacccc  60
aaacaaaga  gaatttgtc  cctcccaga  gtacagcac  aattatgac  agatcctac  120
tgattgtta  tcgtggcct  aagaagttc  agaaaatac  gaccaaagt  aatcagtaa  180
acaacagct  gaattttta  ctttattaa  aagatcttg  agttttcag  gatttttaa  240
agtcagaat  ttttgtgat  attcacagt  tgcttagaa  aaggtgatt  ttgtttagc  300
cacagactc  tgggagtag  ttagtgtaa  ttaggatga  cttcaccct  gacaggttt  360
tttcactta  tgtggcagt  tatgttttc  ctgtgatta  tctctttac  aattctgtt  420
aaaagctac  gtacctgct  ctgagaaag  cctcactgc  atgtaggaa  ctaatggaa  480
acccacact  gtaataaat  aatatagca  aacttgatt  c  521



<210> 3551
<211> 572
<212> PRT
<213> Rattus norvegicus
<308> AAA41563
<400> 3551

Met Asp Pro Arg Ala Pro Arg Arg Arg His Thr His Gln Arg Gly Tyr 
  1               5                  10                  15
Leu Leu Thr Arg Asp Pro His Leu Asn Lys Asp Leu Ala Phe Thr Leu 
             20                  25                  30
Glu Glu Arg Gln Gln Leu Lys Ile His Gly Leu Leu Pro Pro Cys Ile 
         35                  40                  45
Val Asn Gln Glu Ile Gln Val Leu Arg Val Ile Lys Asn Phe Glu Arg 
     50                  55                  60
Leu Asn Ser Asp Phe Asp Arg Tyr Leu Leu Leu Met Asp Leu Gln Asp 
 65                  70                  75                  80
Arg Asn Glu Lys Leu Phe Tyr Ser Val Leu Met Ser Asn Val Glu Lys 
                 85                  90                  95
Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Gln Gln 
             100                105                110
Tyr Ser Leu Ala Phe Arg Lys Pro Arg Gly Leu Phe Ile Ser Ile His 
         115                120                125
Asp Lys Gly His Ile Ala Ser Val Leu Asn Ala Trp Pro Glu Asp Val 
     130                135                140
Val Lys Ala Ile Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly 
 145                150                155                160
Asp Leu Gly Cys Asn Gly Met Gly Ile Pro Val Gly Lys Leu Ala Leu 
                 165                170                175
Tyr Thr Ala Cys Gly Gly Val Asn Pro Gln Gln Cys Leu Pro Ile Thr 
             180                185                190
Leu Asp Val Gly Thr Glu Asn Glu Glu Leu Leu Lys Asp Pro Leu Tyr 
         195                200                205
Ile Gly Leu Arg His Arg Arg Val Arg Gly Pro Glu Tyr Asp Ala Phe 
     210                215                220
Leu Asp Glu Phe Met Glu Ala Ala Ser Ser Lys Tyr Gly Met Asn Cys 
 225                230                235                240
Leu Ile Gln Phe Glu Asp Phe Ala Asn Leu Asn Ala Phe Arg Leu Leu 
                 245                250                255
Asn Lys Tyr Arg Asn Lys Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly 
             260                265                270
Thr Ala Ser Val Ala Val Ala Gly Leu Leu Ala Ala Leu Arg Ile Thr 
         275                280                285
Lys Asn Lys Leu Ser Asp Gln Thr Val Leu Phe Gln Gly Ala Gly Glu 
     290                295                300
Ala Ala Leu Gly Ile Ala His Leu Ile Val Met Ala Met Glu Lys Glu 
 305                310                315                320
Gly Leu Ser Lys Glu Lys Ala Arg Gln Lys Ile Trp Leu Val Asp Ser 
                 325                330                335
Lys Gly Leu Ile Val Lys Gly Arg Ala Ser Leu Thr Glu Glu Lys Glu 
             340                345                350
Val Phe Ala His Glu His Glu Glu Met Lys Asn Leu Glu Ala Ile Val 
         355                360                365
Gln Lys Ile Lys Pro Thr Ala Leu Ile Gly Val Ala Ala Ile Gly Gly 
     370                375                380
Ala Phe Thr Glu Gln Ile Leu Lys Asp Met Ala Ala Phe Asn Glu Arg 
 385                390                395                400
Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala Glu Cys Ser 
                 405                410                415
Ala Glu Glu Cys Tyr Lys Val Thr Lys Gly Arg Ala Ile Phe Ala Ser 
             420                425                430
Gly Ser Pro Phe Asp Pro Val Thr Leu Pro Asp Gly Arg Thr Leu Phe 
         435                440                445
Pro Gly Gln Gly Asn Asn Ser Tyr Val Phe Pro Gly Val Ala Leu Gly 
     450                455                460
Val Val Ala Cys Gly Leu Arg His Ile Asn Asp Ser Val Phe Leu Thr 
 465                470                475                480
Thr Ala Glu Val Ile Ser Gln Gln Val Ser Asp Lys His Leu Glu Glu 
                 485                490                495
Gly Arg Leu Tyr Pro Pro Leu Asn Thr Ile Arg Asp Val Ser Leu Lys 
             500                505                510
Ile Ala Val Lys Ile Val Gln Asp Ala Tyr Lys Glu Lys Met Ala Thr 
         515                520                525
Val Tyr Pro Glu Pro Gln Asn Lys Glu Glu Phe Val Ser Ser Gln Met 
     530                535                540
Tyr Ser Thr Asn Tyr Asp Gln Ile Leu Pro Asp Cys Tyr Ser Trp Pro 
 545                550                555                560
Glu Glu Val Gln Lys Ile Gln Thr Lys Val Asn Gln 
                 565                570



<210> 3552
<211> 1838
<212> DNA
<213> Homo sapiens
<308> L34035
<400> 3552

ccggcgcca  ccatggagc  cgaagcccc  cgtcgccgc  acacccatc  gcgcggcta  60
ctgctgaca  ggaaccctc  cctcaacaa  gacttggcc  ttaccctgg  agagagaca  120
caattgaac  ttcatggat  gttgccacc  tccttcaac  gtcaggaga  ccaggttct  180
agagtagta  aaaatttcg  gcatctgaa  tctgacttt  acaggtatc  tctcttaat  240
gatctccaa  atagaaatg  aaaactctt  tatagagtg  tgacatctg  cattgagaa  300
ttcatgcct  ttgtttata  tcccactgt  ggtctggct  gccaacaat  tagtttggt  360
tttcggaag  caagaggtc  ctttattac  atccacgat  gagggcata  tgcttcagt  420
ctcaatgca  ggccagaag  tgtcatcaa  gccattgtg  tgactgatg  agagcgtat  480
cttggcttg  gagaccttg  ctgtaatgg  atgggcatc  ctgtgggta  attggctct  540
tatacagct  gcggaggga  gaatcctca  gaatgtctg  ctgtcattc  ggatgtggg  600
accgaaaat  aggagttac  taaagatcc  ctctacatt  gactacggc  gagaagagt  660
agaggttct  aatatgatg  ttttttgga  gaattcatg  aggcagttt  ttccaagta  720
ggcatgaat  gccttattc  gtttgaaga  tttgccaat  tgaatgcat  tcgtctcct  780
aacaagtat  gaaaccagt  ttgcacatt  aatgatgat  ttcaaggaa  agcatctgt  840
gcagttgca  gtctccttg  agctcttcg  ataaccaag  acaaactgt  tgatcaaac  900
atactattc  aaggagctg  agaggctgc  ctagggatt  cacacctga  tgtgatggc  960
ttggaaaaa  aaggtttac  aaaggagaa  gccatcaaa  agatatggc  ggttgattc  1020
aaaggatta  tagttaagg  acgtgcttc  ttaacacaa  agaaagaga  gtttgccca  1080
gaacatgaa  aaatgaaga  cctagaagc  attgttcaa  aaataaaac  aactgccct  1140
ataggagtt  ctgcaattg  tggtgcatt  tcagaacaa  ttctcaaag  tatggctgc  1200
ttcaatgaa  ggcctatta  ttttgcttt  agtaatcca  ctagcaaag  agaatgttc  1260
gcagagcag  gctacaaaa  aaccaaggg  cgtgcaatt  ttgccagtg  cagtccttt  1320
gatccagtc  ctctcccag  tggacggac  ctgtttcct  gccaaggca  caattccta  1380
gtgttccct  gagttgctc  tggggtggt  gcctgcgga  tgagacaca  cgatgataa  1440
gtcttcctc  ccactgctg  ggtcatatc  cagcaagtg  cagataaac  cctgcaaga  1500
ggccggctc  atcctcctt  gaataccat  cgagacgtt  cgttgaaaa  tgcagtaaa  1560
attgtgcaa  atgcataca  agaaaagat  gccactgtt  atcctgaac  ccaaaacaa  1620
gaagaattt  tctcctccc  gatgtacag  actaattat  accagatcc  acctgattg  1680
tatccgtgg  ctgcagaag  ccagaaaat  cagaccaaa  tcaaccagt  acgcaacag  1740
taggatttt  aactttatt  gtaaaatct  gaagttttc  tgatcttta  gggtcagaa  1800
cttttatga  gattcatag  atgcttaga  taaggtgc  1838



<210> 3553
<211> 572
<212> PRT
<213> Homo sapiens
<308> P48163
<400> 3553

Met Glu Pro Glu Ala Pro Arg Arg Arg His Thr His Gln Arg Gly Tyr 
  1               5                  10                  15
Leu Leu Thr Arg Asn Pro His Leu Asn Lys Asp Leu Ala Phe Thr Leu 
             20                  25                  30
Glu Glu Arg Gln Gln Leu Asn Ile His Gly Leu Leu Pro Pro Ser Phe 
         35                  40                  45
Asn Ser Gln Glu Ile Gln Val Leu Arg Val Val Lys Asn Phe Glu His 
     50                  55                  60
Leu Asn Ser Asp Phe Asp Arg Tyr Leu Leu Leu Met Asp Leu Gln Asp 
 65                  70                  75                  80
Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr Ser Asp Ile Glu Lys 
                 85                  90                  95
Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Gln Gln 
             100                105                110
Tyr Ser Leu Val Phe Arg Lys Pro Arg Gly Leu Phe Ile Thr Ile His 
         115                120                125
Asp Arg Gly His Ile Ala Ser Val Leu Asn Ala Trp Pro Glu Asp Val 
     130                135                140
Ile Lys Ala Ile Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly 
 145                150                155                160
Asp Leu Gly Cys Asn Gly Met Gly Ile Pro Val Gly Lys Leu Ala Leu 
                 165                170                175
Tyr Thr Ala Cys Gly Gly Met Asn Pro Gln Glu Cys Leu Pro Val Ile 
             180                185                190
Leu Asp Val Gly Thr Glu Asn Glu Glu Leu Leu Lys Asp Pro Leu Tyr 
         195                200                205
Ile Gly Leu Arg Gln Arg Arg Val Arg Gly Ser Glu Tyr Asp Asp Phe 
     210                215                220
Leu Asp Glu Phe Met Glu Ala Val Ser Ser Lys Tyr Gly Met Asn Cys 
 225                230                235                240
Leu Ile Gln Phe Glu Asp Phe Ala Asn Val Asn Ala Phe Arg Leu Leu 
                 245                250                255
Asn Lys Tyr Arg Asn Gln Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly 
             260                265                270
Thr Ala Ser Val Ala Val Ala Gly Leu Leu Ala Ala Leu Arg Ile Thr 
         275                280                285
Lys Asn Lys Leu Ser Asp Gln Thr Ile Leu Phe Gln Gly Ala Gly Glu 
     290                295                300
Ala Ala Leu Gly Ile Ala His Leu Ile Val Met Ala Leu Glu Lys Glu 
 305                310                315                320
Gly Leu Pro Lys Glu Lys Ala Ile Lys Lys Ile Trp Leu Val Asp Ser 
                 325                330                335
Lys Gly Leu Ile Val Lys Gly Arg Ala Ser Leu Thr Gln Glu Lys Glu 
             340                345                350
Lys Phe Ala His Glu His Glu Glu Met Lys Asn Leu Glu Ala Ile Val 
         355                360                365
Gln Glu Ile Lys Pro Thr Ala Leu Ile Gly Val Ala Ala Ile Gly Gly 
     370                375                380
Ala Phe Ser Glu Gln Ile Leu Lys Asp Met Ala Ala Phe Asn Glu Arg 
 385                390                395                400
Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala Glu Cys Ser 
                 405                410                415
Ala Glu Gln Cys Tyr Lys Ile Thr Lys Gly Arg Ala Ile Phe Ala Ser 
             420                425                430
Gly Ser Pro Phe Asp Pro Val Thr Leu Pro Asn Gly Gln Thr Leu Tyr 
         435                440                445
Pro Gly Gln Gly Asn Asn Ser Tyr Val Phe Pro Gly Val Ala Leu Gly 
     450                455                460
Val Val Ala Cys Gly Leu Arg Gln Ile Thr Asp Asn Ile Phe Leu Thr 
 465                470                475                480
Thr Ala Glu Val Ile Ala Gln Gln Val Ser Asp Lys His Leu Glu Glu 
                 485                490                495
Gly Arg Leu Tyr Pro Pro Leu Asn Thr Ile Arg Asp Val Ser Leu Lys 
             500                505                510
Ile Ala Glu Lys Ile Val Lys Asp Ala Tyr Gln Glu Lys Thr Ala Thr 
         515                520                525
Val Tyr Pro Glu Pro Gln Asn Lys Glu Ala Phe Val Arg Ser Gln Met 
     530                535                540
Tyr Ser Thr Asp Tyr Asp Gln Ile Leu Pro Asp Cys Tyr Ser Trp Pro 
 545                550                555                560
Glu Glu Val Gln Lys Ile Gln Thr Lys Val Asp Gln 
                 565                570



<210> 3554
<211> 1658
<212> DNA
<213> Rattus norvegicus
<308> M26686
<400> 3554

aattcgggg  accgtcgcc  cgctgaagg  ggctctata  ctgctcggg  gtgcttcgc  60
atggcctgg  aatccggcg  cgccagcca  tcggagcta  tccacaacc  ccgcaagaa  120
ggaatcatc  agacagata  agtatttga  gtgatgctg  ctacagacc  ctcccacta  180
gcaaaatct  acccttaca  ggattctcc  cagtcaata  gtttccagg  aacaatcag  240
gctcctcac  tgcatgcat  tgcactaga  ctcctgttt  accagctgc  cgaaggcgc  300
aaagcccct  acgtagggt  tggaagtgg  atcctcacc  cgtgttttg  acggatggt  360
ggacacagt  ggaaagtca  tggaattga  cacattaaa  aactagtgg  cgactcaat  420
actaatgtc  aaaaggatg  ccccatgct  ctgtcctct  ggcgagtac  gctggttgt  480
ggcgatgga  gaatggggt  tgctgaaga  gccccttac  atgccattc  cgtcggagc  540
gcagcccca  ttgtgcccc  ggcattaat  gaccagtta  agcctggtg  aagattgat  600
ttgccagtc  gtcctgcag  aggaaacca  atgttggag  agtatgaca  gctacaaga  660
ggcagtgtc  aaatgaagc  tctgatggg  gtgatatac  tgcctttaa  agataaaga  720
aagcagtgg  ccaggtgga  gtgattttc  cttctgctc  ttcttcctc  acacattca  780
gggacgagc  gtgagagca  cctgtagct  ggccgtctg  aacactgca  tggattgct  840
atctcggtc  tcaaagcat  gagagccaa  agcatcacc  cttgttttg  actttgtta  900
actctctta  tttcagcat  aaaatgtgt  gtttttgta  ggtttccta  ttcaaaacg  960
tgcagagcc  gactgatag  ggagggctg  agagtgtta  ctttgtgtt  tttaacatg  1020
cacatttac  ttacaaata  taaaagaaa  ggttctcta  ccggaaagc  tcgtttgtg  1080
cttagtttg  aagagtggc  ttgcttttc  tggacactt  cttctgttc  aatattaat  1140
tatgagatt  cttttgtgt  tcagataac  ccacattca  aagtttagc  tttttttct  1200
tttttatgt  attttggct  gcgagcatt  ttagtggga  gagtcaagt  gttagaatg  1260
ttagtgggg  ggataatgg  tcgaggaga  tataactag  aatttaggt  attttcgtc  1320
ttttgtcat  ggagtgata  gcttaatag  ctcactaga  gaaagctgt  ggaggtgac  1380
ttggttcag  tttttttgt  ggctgagag  catgttagt  ggaggagta  gatagatgg  1440
aaaataatt  ttaacattg  agaaggttg  ggttttgta  gtagtctgt  ccgtaagta  1500
ttgaaattt  tactagtaa  gctaaacct  cggtctttc  caggctgca  aaacatgaa  1560
ggtaattgg  atggttatg  agattatgg  gttggagtt  aatgtggat  ttgaagtta  1620
gacaaatag  gatagtatt  ttccttctc  gaaattcc  1658



<210> 3555
<211> 226
<212> PRT
<213> Rattus norvegicus
<308> P22062
<400> 3555

Ala Trp Lys Ser Gly Gly Ala Ser His Ser Glu Leu Ile His Asn Leu 
  1               5                  10                  15
Arg Lys Asn Gly Ile Ile Lys Thr Asp Lys Val Phe Glu Val Met Leu 
             20                  25                  30
Ala Thr Asp Arg Ser His Tyr Ala Lys Ser Asn Pro Tyr Met Asp Ser 
         35                  40                  45
Pro Gln Ser Ile Gly Phe Gln Ala Thr Ile Ser Ala Pro His Met His 
     50                  55                  60
Ala Tyr Ala Leu Glu Leu Leu Phe Asp Gln Leu His Glu Gly Ala Lys 
 65                  70                  75                  80
Ala Pro Asp Val Gly Ser Gly Ser Gly Ile Leu Thr Ala Cys Phe Ala 
                 85                  90                  95
Arg Met Val Gly His Ser Gly Lys Val Ile Gly Ile Asp His Ile Lys 
             100                105                110
Glu Leu Val Asp Asp Ser Ile Thr Asn Val Lys Lys Asp Asp Pro Met 
         115                120                125
Leu Leu Ser Ser Gly Arg Val Arg Leu Val Val Gly Asp Gly Arg Met 
     130                135                140
Gly Phe Ala Glu Glu Ala Pro Tyr Asp Ala Ile His Val Gly Ala Ala 
 145                150                155                160
Ala Pro Val Val Pro Gln Ala Leu Ile Asp Gln Leu Lys Pro Gly Gly 
                 165                170                175
Arg Leu Ile Leu Pro Val Gly Pro Ala Gly Gly Asn Gln Met Leu Glu 
             180                185                190
Gln Tyr Asp Lys Leu Gln Asp Gly Ser Val Lys Met Lys Pro Leu Met 
         195                200                205
Gly Val Ile Tyr Val Pro Leu Thr Asp Lys Glu Lys Gln Trp Ser Arg 
     210                215                220
Trp Lys 
 225



<210> 3556
<211> 1405
<212> DNA
<213> Homo sapiens
<308> AF219140
<400> 3556

ctgatgaat  ccctaatga  tttggtaaa  atcattaag  taaggtgga  acacatctt  60
tcatatgat  aaatggttt  gcgaaaaat  aataatcag  caacaagat  tgcgaactc  120
atattttac  cgactctct  taccaattc  gccccgaat  acacttaaa  cgactcaac  180
gcttaacgt  ggcttgcca  gcattactt  actgtaaaa  tctcactct  accgaactt  240
gccgtaacc  gccaaccaa  gcgagaaca  aacataaca  caaacgaat  gaccgattg  300
taggtaatc  tcacctcca  aaagagcga  tcgctgtat  ccgttggca  gctagcttt  360
tctgttcgg  caatacgat  cccattgta  ttgttgact  gtctgatat  cgtgagcaa  420
aacgactta  ggtatttcg  gtttgtttc  agtactggg  aaaagatcg  ccgggaacc  480
cgtataatg  ctcatgtgg  ggaggcgag  accagtcac  acgaccgaa  atttcacgg  540
accatatta  gcaatcttt  gacccaacc  tgaaccaat  cagctcatt  tccttttca  600
gttatacgt  tgaatcctc  ccttttgaa  ctttgggat  ctcgttgaa  gtactatac  660
gtagatcag  gagtttctg  aatccgata  tctccgact  gttttcgtt  ggttatagt  720
cgtttaaga  aacatattt  gagcgagat  tccggcttt  ttattcgcg  gctgtgcct  780
agtatcagt  gtgggcagt  gattttaga  gcgtcgcag  cgtttcctc  gtgcctaag  840
tcgttgatt  gatggacaa  tttaagctt  tgggtttgt  gaacaatta  agatatgct  900
cgcttacgt  taacttctt  ggaaggctc  caacttttc  ggacggatg  ctgatccgc  960
tgcggtatc  gcttgctcg  cgagtctcg  aaaactata  tacgacgat  agcgggact  1020
cgaagttga  tgtacaacc  aacgcccgc  agtacgagt  tttgttcca  ccctgttcg  1080
ggaggtccg  ttgtgtcag  ctttagctt  gcatgagag  tgtcaagcg  atccgtacc  1140
tcaaaacgc  gtaagaccg  tgtgttatt  ttcccttct  aatgagcac  gacgttggg  1200
tgatcgagt  ttaataaag  gtgtaccaa  gcgaaaccc  tttaatact  ccctagaga  1260
tcacgtatc  aactcatac  caatgggaa  agattgtga  gcctgtgga  agtttcagc  1320
ccccgagtt  ggggaaaac  gctaaactg  cagattagg  tttttaaaa  aaagattgg  1380
ttataactc  aaaaaaaaa  aaaaa  1405



<210> 3557
<211> 226
<212> PRT
<213> Homo sapiens
<308> P22061
<400> 3557

Ala Trp Lys Ser Gly Gly Ala Ser His Ser Glu Leu Ile His Asn Leu 
  1               5                  10                  15
Arg Lys Asn Gly Ile Ile Lys Thr Asp Lys Val Phe Glu Val Met Leu 
             20                  25                  30
Ala Thr Asp Arg Ser His Tyr Ala Lys Cys Asn Pro Tyr Met Asp Ser 
         35                  40                  45
Pro Gln Ser Ile Gly Phe Gln Ala Thr Ile Ser Ala Pro His Met His 
     50                  55                  60
Ala Tyr Ala Leu Glu Leu Leu Phe Asp Gln Leu His Glu Gly Ala Lys 
 65                  70                  75                  80
Ala Leu Asp Val Gly Ser Gly Ser Gly Ile Leu Thr Ala Cys Phe Ala 
                 85                  90                  95
Arg Met Val Gly Cys Thr Gly Lys Val Ile Gly Ile Asp His Ile Lys 
             100                105                110
Glu Leu Val Asp Asp Ser Ile Asn Asn Val Arg Lys Asp Asp Pro Thr 
         115                120                125
Leu Leu Ser Ser Gly Arg Val Gln Leu Val Val Gly Asp Gly Arg Met 
     130                135                140
Gly Tyr Ala Glu Glu Ala Pro Tyr Asp Ala Ile His Val Gly Ala Ala 
 145                150                155                160
Ala Pro Val Val Pro Gln Ala Leu Ile Asp Gln Leu Lys Pro Gly Gly 
                 165                170                175
Arg Leu Ile Leu Pro Val Gly Pro Ala Gly Gly Asn Gln Met Leu Glu 
             180                185                190
Gln Tyr Asp Lys Leu Gln Asp Gly Ser Ile Lys Met Lys Pro Leu Met 
         195                200                205
Gly Val Ile Tyr Val Pro Leu Thr Asp Lys Glu Lys Gln Trp Ser Arg 
     210                215                220
Trp Lys 
 225



<210> 3558
<211> 1658
<212> DNA
<213> Rattus norvegicus
<308> M26686
<400> 3558

aattcgggg  accgtcgcc  cgctgaagg  ggctctata  ctgctcggg  gtgcttcgc  60
atggcctgg  aatccggcg  cgccagcca  tcggagcta  tccacaacc  ccgcaagaa  120
ggaatcatc  agacagata  agtatttga  gtgatgctg  ctacagacc  ctcccacta  180
gcaaaatct  acccttaca  ggattctcc  cagtcaata  gtttccagg  aacaatcag  240
gctcctcac  tgcatgcat  tgcactaga  ctcctgttt  accagctgc  cgaaggcgc  300
aaagcccct  acgtagggt  tggaagtgg  atcctcacc  cgtgttttg  acggatggt  360
ggacacagt  ggaaagtca  tggaattga  cacattaaa  aactagtgg  cgactcaat  420
actaatgtc  aaaaggatg  ccccatgct  ctgtcctct  ggcgagtac  gctggttgt  480
ggcgatgga  gaatggggt  tgctgaaga  gccccttac  atgccattc  cgtcggagc  540
gcagcccca  ttgtgcccc  ggcattaat  gaccagtta  agcctggtg  aagattgat  600
ttgccagtc  gtcctgcag  aggaaacca  atgttggag  agtatgaca  gctacaaga  660
ggcagtgtc  aaatgaagc  tctgatggg  gtgatatac  tgcctttaa  agataaaga  720
aagcagtgg  ccaggtgga  gtgattttc  cttctgctc  ttcttcctc  acacattca  780
gggacgagc  gtgagagca  cctgtagct  ggccgtctg  aacactgca  tggattgct  840
atctcggtc  tcaaagcat  gagagccaa  agcatcacc  cttgttttg  actttgtta  900
actctctta  tttcagcat  aaaatgtgt  gtttttgta  ggtttccta  ttcaaaacg  960
tgcagagcc  gactgatag  ggagggctg  agagtgtta  ctttgtgtt  tttaacatg  1020
cacatttac  ttacaaata  taaaagaaa  ggttctcta  ccggaaagc  tcgtttgtg  1080
cttagtttg  aagagtggc  ttgcttttc  tggacactt  cttctgttc  aatattaat  1140
tatgagatt  cttttgtgt  tcagataac  ccacattca  aagtttagc  tttttttct  1200
tttttatgt  attttggct  gcgagcatt  ttagtggga  gagtcaagt  gttagaatg  1260
ttagtgggg  ggataatgg  tcgaggaga  tataactag  aatttaggt  attttcgtc  1320
ttttgtcat  ggagtgata  gcttaatag  ctcactaga  gaaagctgt  ggaggtgac  1380
ttggttcag  tttttttgt  ggctgagag  catgttagt  ggaggagta  gatagatgg  1440
aaaataatt  ttaacattg  agaaggttg  ggttttgta  gtagtctgt  ccgtaagta  1500
ttgaaattt  tactagtaa  gctaaacct  cggtctttc  caggctgca  aaacatgaa  1560
ggtaattgg  atggttatg  agattatgg  gttggagtt  aatgtggat  ttgaagtta  1620
gacaaatag  gatagtatt  ttccttctc  gaaattcc  1658



<210> 3559
<211> 226
<212> PRT
<213> Rattus norvegicus
<308> P22062
<400> 3559

Ala Trp Lys Ser Gly Gly Ala Ser His Ser Glu Leu Ile His Asn Leu 
  1               5                  10                  15
Arg Lys Asn Gly Ile Ile Lys Thr Asp Lys Val Phe Glu Val Met Leu 
             20                  25                  30
Ala Thr Asp Arg Ser His Tyr Ala Lys Ser Asn Pro Tyr Met Asp Ser 
         35                  40                  45
Pro Gln Ser Ile Gly Phe Gln Ala Thr Ile Ser Ala Pro His Met His 
     50                  55                  60
Ala Tyr Ala Leu Glu Leu Leu Phe Asp Gln Leu His Glu Gly Ala Lys 
 65                  70                  75                  80
Ala Pro Asp Val Gly Ser Gly Ser Gly Ile Leu Thr Ala Cys Phe Ala 
                 85                  90                  95
Arg Met Val Gly His Ser Gly Lys Val Ile Gly Ile Asp His Ile Lys 
             100                105                110
Glu Leu Val Asp Asp Ser Ile Thr Asn Val Lys Lys Asp Asp Pro Met 
         115                120                125
Leu Leu Ser Ser Gly Arg Val Arg Leu Val Val Gly Asp Gly Arg Met 
     130                135                140
Gly Phe Ala Glu Glu Ala Pro Tyr Asp Ala Ile His Val Gly Ala Ala 
 145                150                155                160
Ala Pro Val Val Pro Gln Ala Leu Ile Asp Gln Leu Lys Pro Gly Gly 
                 165                170                175
Arg Leu Ile Leu Pro Val Gly Pro Ala Gly Gly Asn Gln Met Leu Glu 
             180                185                190
Gln Tyr Asp Lys Leu Gln Asp Gly Ser Val Lys Met Lys Pro Leu Met 
         195                200                205
Gly Val Ile Tyr Val Pro Leu Thr Asp Lys Glu Lys Gln Trp Ser Arg 
     210                215                220
Trp Lys 
 225



<210> 3560
<211> 1405
<212> DNA
<213> Homo sapiens
<308> AF219140
<400> 3560

ctgatgaat  ccctaatga  tttggtaaa  atcattaag  taaggtgga  acacatctt  60
tcatatgat  aaatggttt  gcgaaaaat  aataatcag  caacaagat  tgcgaactc  120
atattttac  cgactctct  taccaattc  gccccgaat  acacttaaa  cgactcaac  180
gcttaacgt  ggcttgcca  gcattactt  actgtaaaa  tctcactct  accgaactt  240
gccgtaacc  gccaaccaa  gcgagaaca  aacataaca  caaacgaat  gaccgattg  300
taggtaatc  tcacctcca  aaagagcga  tcgctgtat  ccgttggca  gctagcttt  360
tctgttcgg  caatacgat  cccattgta  ttgttgact  gtctgatat  cgtgagcaa  420
aacgactta  ggtatttcg  gtttgtttc  agtactggg  aaaagatcg  ccgggaacc  480
cgtataatg  ctcatgtgg  ggaggcgag  accagtcac  acgaccgaa  atttcacgg  540
accatatta  gcaatcttt  gacccaacc  tgaaccaat  cagctcatt  tccttttca  600
gttatacgt  tgaatcctc  ccttttgaa  ctttgggat  ctcgttgaa  gtactatac  660
gtagatcag  gagtttctg  aatccgata  tctccgact  gttttcgtt  ggttatagt  720
cgtttaaga  aacatattt  gagcgagat  tccggcttt  ttattcgcg  gctgtgcct  780
agtatcagt  gtgggcagt  gattttaga  gcgtcgcag  cgtttcctc  gtgcctaag  840
tcgttgatt  gatggacaa  tttaagctt  tgggtttgt  gaacaatta  agatatgct  900
cgcttacgt  taacttctt  ggaaggctc  caacttttc  ggacggatg  ctgatccgc  960
tgcggtatc  gcttgctcg  cgagtctcg  aaaactata  tacgacgat  agcgggact  1020
cgaagttga  tgtacaacc  aacgcccgc  agtacgagt  tttgttcca  ccctgttcg  1080
ggaggtccg  ttgtgtcag  ctttagctt  gcatgagag  tgtcaagcg  atccgtacc  1140
tcaaaacgc  gtaagaccg  tgtgttatt  ttcccttct  aatgagcac  gacgttggg  1200
tgatcgagt  ttaataaag  gtgtaccaa  gcgaaaccc  tttaatact  ccctagaga  1260
tcacgtatc  aactcatac  caatgggaa  agattgtga  gcctgtgga  agtttcagc  1320
ccccgagtt  ggggaaaac  gctaaactg  cagattagg  tttttaaaa  aaagattgg  1380
ttataactc  aaaaaaaaa  aaaaa  1405



<210> 3561
<211> 226
<212> PRT
<213> Homo sapiens
<308> P22061
<400> 3561

Ala Trp Lys Ser Gly Gly Ala Ser His Ser Glu Leu Ile His Asn Leu 
  1               5                  10                  15
Arg Lys Asn Gly Ile Ile Lys Thr Asp Lys Val Phe Glu Val Met Leu 
             20                  25                  30
Ala Thr Asp Arg Ser His Tyr Ala Lys Cys Asn Pro Tyr Met Asp Ser 
         35                  40                  45
Pro Gln Ser Ile Gly Phe Gln Ala Thr Ile Ser Ala Pro His Met His 
     50                  55                  60
Ala Tyr Ala Leu Glu Leu Leu Phe Asp Gln Leu His Glu Gly Ala Lys 
 65                  70                  75                  80
Ala Leu Asp Val Gly Ser Gly Ser Gly Ile Leu Thr Ala Cys Phe Ala 
                 85                  90                  95
Arg Met Val Gly Cys Thr Gly Lys Val Ile Gly Ile Asp His Ile Lys 
             100                105                110
Glu Leu Val Asp Asp Ser Ile Asn Asn Val Arg Lys Asp Asp Pro Thr 
         115                120                125
Leu Leu Ser Ser Gly Arg Val Gln Leu Val Val Gly Asp Gly Arg Met 
     130                135                140
Gly Tyr Ala Glu Glu Ala Pro Tyr Asp Ala Ile His Val Gly Ala Ala 
 145                150                155                160
Ala Pro Val Val Pro Gln Ala Leu Ile Asp Gln Leu Lys Pro Gly Gly 
                 165                170                175
Arg Leu Ile Leu Pro Val Gly Pro Ala Gly Gly Asn Gln Met Leu Glu 
             180                185                190
Gln Tyr Asp Lys Leu Gln Asp Gly Ser Ile Lys Met Lys Pro Leu Met 
         195                200                205
Gly Val Ile Tyr Val Pro Leu Thr Asp Lys Glu Lys Gln Trp Ser Arg 
     210                215                220
Trp Lys 
 225



<210> 3562
<211> 418
<212> DNA
<213> Rattus norvegicus
<308> M27467
<400> 3562

gccatggnc  ttcacctta  ggttaccca  gatagcaga  gcagaggac  ttggctacc  60
tcagttccg  tgctctgtt  ccgaaacca  agatgcgtg  tcttctggc  aagcgtctg  120
gggttcata  tgttggcgc  ttcgctgtg  ccctaggag  tgctgctgc  tataagttt  180
gcgtggctg  accaagaaa  aaggcttat  cagatttct  caggaatta  gactccatg  240
aagattttg  agagatgag  caggctggt  tctttcaga  tgcgaagtg  tttcagaat  300
caaagaatt  tttggattg  gctccatag  agttcactg  tgacctgtg  tcctgaact  360
tgaaacgtg  atatgtggg  taaggagta  tttctctca  taaacatta  ttatatgg  418



<210> 3563
<211> 75
<212> PRT
<213> Rattus norvegicus
<308> P11951
<400> 3563

Ser Ser Gly Ala Leu Leu Pro Lys Pro Gln Met Arg Gly Leu Leu Ala 
  1               5                  10                  15
Lys Arg Leu Arg Val His Ile Val Gly Ala Phe Val Val Ala Leu Gly 
             20                  25                  30
Val Ala Ala Ala Tyr Lys Phe Gly Val Ala Glu Pro Arg Lys Lys Ala 
         35                  40                  45
Tyr Ala Asp Phe Tyr Arg Asn Tyr Asp Ser Met Lys Asp Phe Glu Glu 
     50                  55                  60
Met Arg Gln Ala Gly Val Phe Gln Ser Ala Lys 
 65                  70                  75



<210> 3564
<211> 504
<212> DNA
<213> Homo sapiens
<308> BG952851
<400> 3564

gctgggtgn  ctagaggat  ccgtgtggt  gtgtgcgct  taatcccag  cactcaaga  60
gctgaggca  gagaagcgc  tgaacctgg  aggcggagg  tgtagtcag  cgagatcgt  120
ccattgcac  ccagcctgg  aacagagca  gactcaaaa  aaataaata  aataaaata  180
aataaaatg  gtcaggaat  atgttggtg  tgaggttgg  atacgtatc  aggacagta  240
ctaccatga  tcccgaagt  ttgccaaaa  ctcagatgt  tggccttct  gccaagcgt  300
tgcgatttc  atgtttgga  cattcatgg  gtccctggg  gttgcagct  tgtatgagt  360
tggtgtggg  gatccaaga  agaaggcat  tgcagattt  tgcagaaat  atgagattt  420
gagcagatg  ggaaggctg  tatctttca  tttaaagta  tcttggaat  taaagaatt  480
cttcaggtt  aattaccca  aagt  504



<210> 3565
<211> 75
<212> PRT
<213> Homo sapiens
<308> P09669
<400> 3565

Met Ala Pro Glu Val Leu Pro Lys Pro Arg Met Arg Gly Leu Leu Ala 
  1               5                  10                  15
Arg Arg Leu Arg Asn His Met Ala Val Ala Phe Val Leu Ser Leu Gly 
             20                  25                  30
Val Ala Ala Leu Tyr Lys Phe Arg Val Ala Asp Gln Arg Lys Lys Ala 
         35                  40                  45
Tyr Ala Asp Phe Tyr Arg Asn Tyr Asp Val Met Lys Asp Phe Glu Glu 
     50                  55                  60
Met Arg Lys Ala Gly Ile Phe Gln Ser Val Lys 
 65                  70                  75



<210> 3566
<211> 484
<212> DNA
<213> Rattus norvegicus
<308> M27726
<400> 3566

cggatccat  agtacaagc  gcagctgct  aactgctta  acatcatca  cctgtacaa  60
cgaataaag  aggatccaa  caagacctt  gtgcccagg  ctgttatga  cggaggcaa  120
gcagctcct  gttaccaca  ggctaagat  atcatcaag  tggtcacat  cattggaga  180
gttgtcaat  atgatccag  tgtgggcga  aggctcaga  tgatcttcc  ggagaacta  240
cgtgtgtct  tagctgaga  agtgatccc  gccgccgac  tgtcacagc  gatctccac  300
gcgggcacc  aggcctcgg  caccggcaa  atgaagttc  tgctcaacg  agctctcac  360
atcggcacc  tggatggtg  caacgtgga  atggccgag  aggccgggg  ggagaacct  420
ttcatcttt  gtatgcggg  ggaagatgt  gaggccttg  accagaaag  gtacaatgc  480
caga  484



<210> 3567
<211> 838
<212> PRT
<213> Rattus norvegicus
<308> AAA40815
<400> 3567

Met Ala Lys Pro Leu Thr Asp Ser Glu Arg Gln Lys Gln Ile Ser Val 
  1               5                  10                  15
Arg Gly Ile Ala Gly Leu Gly Asp Val Ala Glu Val Arg Lys Ser Phe 
             20                  25                  30
Asn Arg His Leu His Phe Thr Leu Val Lys Asp Arg Asn Val Ala Thr 
         35                  40                  45
Pro Arg Asp Tyr Phe Phe Ala Leu Ala His Thr Val Arg Asp His Leu 
     50                  55                  60
Val Gly Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Glu Arg Asp Pro 
 65                  70                  75                  80
Lys Arg Ile Tyr Tyr Leu Ser Leu Glu Phe Tyr Met Gly Arg Thr Leu 
                 85                  90                  95
Gln Asn Thr Met Val Asn Leu Gly Leu Gln Thr Ala Cys Asp Glu Ala 
             100                105                110
Thr Tyr Gln Leu Gly Leu Asp Leu Glu Glu Leu Glu Glu Ile Glu Glu 
         115                120                125
Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe 
     130                135                140
Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile 
 145                150                155                160
Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile Val Asn Gly Trp Gln 
                 165                170                175
Val Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys 
             180                185                190
Ala Arg Pro Glu Tyr Met Leu Pro Val His Phe Tyr Gly Arg Val Glu 
         195                200                205
His Thr Pro Asn Gly Val Leu Trp Leu Asp Thr Gln Val Val Leu Ala 
     210                215                220
Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Lys Asn Asn Thr Val Asn 
 225                230                235                240
Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Asn Asp Phe Lys Leu Lys 
                 245                250                255
Asp Phe Asn Val Gly Asp Tyr Ile Glu Ala Val Leu Asp Arg Asn Leu 
             260                265                270
Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Asn Phe Phe Glu 
         275                280                285
Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr 
     290                295                300
Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser Lys Phe Gly Cys Arg 
 305                310                315                320
Asp Pro Val Arg Thr Cys Phe Glu Thr Phe Pro Asp Lys Val Ala Ile 
                 325                330                335
Gln Leu Asn Asp Thr His Pro Ala Leu Ser Ile Pro Glu Leu Met Arg 
             340                345                350
Ile Leu Val Asp Val Glu Lys Val Asp Trp Asp Lys Ala Trp Glu Ile 
         355                360                365
Thr Lys Lys Thr Cys Ala Tyr Thr Asn His Thr Val Leu Pro Glu Ala 
     370                375                380
Leu Glu Arg Trp Pro Val Ser Met Phe Glu Lys Leu Leu Pro Arg His 
 385                390                395                400
Leu Glu Ile Ile Tyr Ala Ile Asn Gln Arg His Leu Asp His Val Ala 
                 405                410                415
Ala Leu Phe Pro Gly Asp Val Asp Arg Leu Arg Arg Met Ser Val Ile 
             420                425                430
Glu Glu Gly Asp Cys Lys Arg Ile Asn Met Ala His Leu Cys Val Ile 
         435                440                445
Gly Ser His Ala Val Asn Gly Val Ala Arg Ile His Ser Glu Ile Val 
     450                455                460
Lys Gln Ser Val Phe Lys Asp Phe Tyr Glu Leu Glu Pro Glu Lys Phe 
 465                470                475                480
Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Leu Leu Cys 
                 485                490                495
Asn Pro Gly Leu Ala Glu Ile Ile Val Glu Arg Ile Gly Glu Gly Phe 
             500                505                510
Leu Thr Asp Leu Ser Gln Leu Lys Lys Leu Leu Ser Leu Val Asp Asp 
         515                520                525
Glu Ala Phe Ile Arg Asp Val Ala Lys Val Lys Gln Glu Asn Lys Leu 
     530                535                540
Lys Phe Ser Ala Gln Leu Glu Lys Glu Tyr Lys Val Lys Ile Asn Pro 
 545                550                555                560
Cys Ser Met Phe Asp Val His Val Lys Arg Ile His Glu Tyr Lys Arg 
                 565                570                575
Gln Leu Leu Asn Cys Leu His Ile Ile Thr Leu Tyr Asn Arg Ile Lys 
             580                585                590
Lys Asp Pro Thr Lys Thr Phe Val Pro Arg Thr Val Met Ile Gly Gly 
         595                600                605
Lys Ala Ala Pro Gly Tyr His Met Ala Lys Met Ile Ile Lys Leu Val 
     610                615                620
Thr Ser Ile Gly Asp Val Val Asn His Asp Pro Val Val Gly Asp Arg 
 625                630                635                640
Leu Arg Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu Lys 
                 645                650                655
Val Ile Pro Ala Ala Asp Leu Ser Gln Gln Ile Ser Thr Ala Gly Thr 
             660                665                670
Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala Leu 
         675                680                685
Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu Ala 
     690                695                700
Gly Glu Glu Asn Leu Phe Ile Phe Gly Met Arg Val Glu Asp Val Glu 
 705                710                715                720
Ala Leu Asp Gln Lys Gly Tyr Asn Ala Gln Glu Phe Tyr Glu Arg Leu 
                 725                730                735
Pro Glu Leu Arg Gln Ala Val Asp Gln Ile Ser Ser Gly Phe Phe Ser 
             740                745                750
Pro Lys Asp Pro Asp Cys Phe Lys Asp Val Val Asn Met Leu Met Tyr 
         755                760                765
His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Ala Tyr Ile Gln Cys 
     770                775                780
Gln Ala Gln Val Asp His Leu Tyr Arg Asn Pro Lys Asp Trp Thr Lys 
 785                790                795                800
Lys Val Ile Arg Asn Ile Ala Cys Ser Gly Lys Phe Ser Ser Asp Arg 
                 805                810                815
Thr Ile Thr Glu Tyr Ala Arg Glu Ile Trp Gly Val Glu Pro Ser Asp 
             820                825                830
Leu Gln Ile Pro Pro Pro 
         835



<210> 3568
<211> 3816
<212> DNA
<213> Homo sapiens
<308> J03544
<400> 3568

gagcagctg  accatcccg  cgttcgcgt  tgccgccgc  ttcctcctc  atctctttt  60
ctccgcctc  gccggcgcg  tgggcgaac  gctgacgga  agcgagaag  ggaagcaga  120
cagcgtgcg  ggcctggcg  ggctaggcg  cgtggccga  gtgcggaag  gcttcaacc  180
gcacttgca  ttcacgctg  tcaaggacc  caatgtggc  acgccccgc  actacttct  240
cgcgctggc  cacacggtg  gcgaccacc  cgtgggccg  tggatccgc  cgcagcagc  300
ctactacga  cgcgacccc  agcgaattt  ttatctttc  ctggaattc  acatgggtc  360
cacgctgca  aacacgatg  tgaacctgg  ccttcagaa  gcctgcgat  aagccatct  420
tcagttggg  ttagacttg  aggaactcg  ggagataga  gaagatgct  gccttggga  480
tggaggcct  gggaggctg  cagcgtgtt  ccttgactc  atggctacc  tgggcctgg  540
agcatacgg  tatggaatc  gctatgaat  tgggatttt  aaccagaag  ttgtcaatg  600
ctggcaggt  gaggaggcc  atgactggc  gcgctacgg  aacccctgg  agaaagcgc  660
gcctgagta  atgcttccc  tgcacttct  cggacgcgt  gagcacacc  ccgacggcg  720
gaagtggct  gacacacag  tggtgctgg  catgcccta  gacacccca  tgcccggct  780
caagaacaa  accgtcaac  ccatgcggc  gtggtccgc  agggctccc  acgacttca  840
gctgcagga  ttcaacgtg  gagactaca  cgaggcggt  ctggaccgg  acttggctg  900
gaacatctc  agggtcctg  atccaaatg  taacttctt  gaggggaag  agctgcggc  960
gaagcagga  tacttcgtg  tgggcgcca  gctccagga  atcatccgc  gcttcaagt  1020
gtccaagtt  ggctgccgg  accctgtga  aacctgttt  gagacgttc  cagacaagg  1080
ggccatcca  ctgaacgac  cccaccccg  cctctccat  cctgagctc  tgcggatcc  1140
ggtggacgt  gagaaggtg  actgggaca  ggcctggga  atcacgaag  agacctgtg  1200
atacaccaa  cacactgtg  tgcctgagg  cttggagcg  tggcccgtg  ccatgtttg  1260
gaagctgct  ccgcggcac  tggagataa  ctatgccat  aaccagcgg  acctggacc  1320
cgtggccgc  ctgtttccc  gcgatgtgg  ccgcctgcg  aggatgtct  tgatcgagg  1380
gggggactg  aagcggatc  acatggccc  cctgtgtgt  attgggtcc  atgctgtca  1440
tggtgtggc  aggatccac  cggagatcg  gaaacagtc  gtctttaag  atttttatg  1500
actggagcc  gagaagttc  agaataaga  caatggcat  accccccgc  ggtggctgc  1560
gctgtgcaa  ccggggctg  ccgatacca  cgtggagaa  attggggag  agttcctga  1620
tgacctgag  cagctgaag  agctgctgc  gctggtcag  gacgaggtg  tcatcaggg  1680
cgtggccaa  gtcaaacag  agaacaagc  caagttctc  gccttcctg  agaaggagt  1740
caaggtgaa  atcaacccc  cctccatgt  cgatgtgca  gtgaagagg  tccacgagt  1800
caagcggca  ctgctcaac  gcctgcacg  cgtcaccct  tacaatcga  tcaagagag  1860
cccggccaa  gcttttgtg  ccaggactg  tatgattgg  ggcaaggca  cgcccggtt  1920
ccacatggc  aagctgatc  tcaagttgg  cacctccat  ggcgacgtc  tcaatcatg  1980
cccagttgt  ggtgacagg  tgaaagtga  cttcctgga  aactaccgt  tgtccttgg  2040
tgagaaagt  atcccggcc  ctgatctgt  gcagcagat  tccactgca  gcaccgagg  2100
ctcaggcac  ggcaacatg  agttcatgc  caacggggc  ctcaccatc  gcaccatgg  2160
cggcgccaa  gtggagatg  ccgaggagg  cggggccga  aacctcttc  tcttcggcc  2220
gcgggtgga  gatgtcgag  ccttggacc  gaaagggta  aatgccagg  agtactacg  2280
ccacctgcc  gagctgaag  aggccgtgg  ccagatcag  agtggcttt  tttctccca  2340
ggagccaga  tgcttcaag  acatcgtga  catgctgat  caccatgac  ggttcaagg  2400
gtttgcaga  tatgaagcc  acatgcagt  ccaggcaca  gtggaccag  tgtaccgga  2460
ccccaagga  tggaccaag  aggtcatca  gaacatcgc  tgctcgggc  agttctcca  2520
tgaccggac  atcacggag  atgcacggg  gatctgggg  gtggagccc  ccgacctgc  2580
gcttcagca  ctgccccac  cagagtggg  gtcaggtgg  gccacctgc  gggctcccc  2640
agaactttg  acacatctt  ctatgtatt  gccgatggc  ttagtgttg  gcctctgga  2700
tctggggtc  gcggcagtg  ccatagtga  gcctgggaa  gagtgttac  gcagcatct  2760
gctgccagc  acagggaag  gccaagccc  atgtagccc  agtcatcct  cccagccct  2820
cctcctggc  atgccggga  gggtcggat  ctctaggca  cgcttcaca  ccccctgcc  2880
cctgccctc  gtcctggct  tgcacctgg  atatgggtc  tggaccaga  ggggctttc  2940
ctttgtagc  atccaatgg  cattgtgtg  gtgcttgga  cccgggatg  ctgaggggg  3000
cactggagt  ggtgcttgt  tctgctgtc  cagaggcct  ggtcaggat  aagttggct  3060
acacagctt  gcttggttt  gcttattca  aagagaaaa  aactacaca  ggaaatgaa  3120
ctagtgaag  cttttcttg  tttagaatg  aaattgtac  tggtcactt  tgtgcttga  3180
gaggcccat  ttctagcct  gcaggggca  gtcctgtgc  ctcccgctt  actcctgct  3240
tgtcctgag  tgcatttcc  gtttgttac  cacaagggc  aggctccat  ctccctccc  3300
ttccaccag  gccacagcc  cgtctggaa  aaggaccag  ggtcccgga  gaacccatt  3360
gtgctctgc  tggacagca  gcctggcac  gggaggtgg  gtgagcccc  cacagcctt  3420
cccctcccc  aggctcgaa  ctgcctccc  ttgcccaag  gagaggggc  gggaacagg  3480
tactgtcct  ccctgtgga  ttgccgaga  atctagcac  ttgcatgct  gatctgggc  3540
gcggggagg  tctttttct  cctggcctc  agtgcccac  aggaggatc  gcgcacggt  3600
cacagccca  cagagcact  cagcctttt  ttgagtggg  caagtgctg  gctgtggtc  3660
tgccctgac  gcatcttcc  caggcagcg  ctctgtgga  gaggccata  tcccctagt  3720
ggccactgg  gccaccacc  tgaccacca  tgtgcccct  attgttact  ccttgtgag  3780
taaaaactg  ttaaacctt  gtggctttg  ttggtt  3816



<210> 3569
<211> 843
<212> PRT
<213> Homo sapiens
<308> P11216
<400> 3569

Met Ala Lys Pro Leu Thr Asp Ser Glu Lys Arg Lys Gln Ile Ser Val 
  1               5                  10                  15
Arg Gly Leu Ala Gly Leu Gly Asp Val Ala Glu Val Arg Lys Ser Phe 
             20                  25                  30
Asn Arg His Leu His Phe Thr Leu Val Lys Asp Arg Asn Val Ala Thr 
         35                  40                  45
Pro Arg Asp Tyr Phe Phe Ala Leu Ala His Thr Val Arg Asp His Leu 
     50                  55                  60
Val Gly Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Glu Arg Asp Pro 
 65                  70                  75                  80
Lys Arg Ile Tyr Tyr Leu Ser Leu Glu Phe Tyr Met Gly Arg Thr Leu 
                 85                  90                  95
Gln Asn Thr Met Val Asn Leu Gly Leu Gln Asn Ala Cys Asp Glu Ala 
             100                105                110
Ile Tyr Gln Leu Gly Leu Asp Leu Glu Glu Leu Glu Glu Ile Glu Glu 
         115                120                125
Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe 
     130                135                140
Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile 
 145                150                155                160
Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile Val Asn Gly Trp Gln 
                 165                170                175
Val Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys 
             180                185                190
Ala Arg Pro Glu Tyr Met Leu Pro Val His Phe Tyr Gly Arg Val Glu 
         195                200                205
His Thr Pro Asp Gly Val Lys Trp Leu Asp Thr Gln Val Val Leu Ala 
     210                215                220
Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Lys Asn Asn Thr Val Asn 
 225                230                235                240
Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Asn Asp Phe Lys Leu Gln 
                 245                250                255
Asp Phe Asn Val Gly Asp Tyr Ile Glu Ala Val Leu Asp Arg Asn Leu 
             260                265                270
Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Asn Phe Phe Glu 
         275                280                285
Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr 
     290                295                300
Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser Lys Phe Gly Cys Arg 
 305                310                315                320
Asp Pro Val Arg Thr Cys Phe Glu Thr Phe Pro Asp Lys Val Ala Ile 
                 325                330                335
Gln Leu Asn Asp Thr His Pro Ala Leu Ser Ile Pro Glu Leu Met Arg 
             340                345                350
Ile Leu Val Asp Val Glu Lys Val Asp Trp Asp Lys Ala Trp Glu Ile 
         355                360                365
Thr Lys Lys Thr Cys Ala Tyr Thr Asn His Thr Val Leu Pro Glu Ala 
     370                375                380
Leu Glu Arg Trp Pro Val Ser Met Phe Glu Lys Leu Leu Pro Arg His 
 385                390                395                400
Leu Glu Ile Ile Tyr Ala Ile Asn Gln Arg His Leu Asp His Val Ala 
                 405                410                415
Ala Leu Phe Pro Gly Asp Val Asp Arg Leu Arg Arg Met Ser Val Ile 
             420                425                430
Glu Glu Gly Asp Cys Lys Arg Ile Asn Met Ala His Leu Cys Val Ile 
         435                440                445
Gly Ser His Ala Val Asn Gly Val Ala Arg Ile His Ser Glu Ile Val 
     450                455                460
Lys Gln Ser Val Phe Lys Asp Phe Tyr Glu Leu Glu Pro Glu Lys Phe 
 465                470                475                480
Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Leu Leu Cys 
                 485                490                495
Asn Pro Gly Leu Ala Asp Thr Ile Val Glu Lys Ile Gly Glu Glu Phe 
             500                505                510
Leu Thr Asp Leu Ser Gln Leu Lys Lys Leu Leu Pro Leu Val Ser Asp 
         515                520                525
Glu Val Phe Ile Arg Asp Val Ala Lys Val Lys Gln Glu Asn Lys Leu 
     530                535                540
Lys Phe Ser Ala Phe Leu Glu Lys Glu Tyr Lys Val Lys Ile Asn Pro 
 545                550                555                560
Ser Ser Met Phe Asp Val His Val Lys Arg Ile His Glu Tyr Lys Arg 
                 565                570                575
Gln Leu Leu Asn Cys Leu His Val Val Thr Leu Tyr Asn Arg Ile Lys 
             580                585                590
Arg Asp Pro Ala Lys Ala Phe Val Pro Arg Thr Val Met Ile Gly Gly 
         595                600                605
Lys Ala Ala Pro Gly Tyr His Met Ala Lys Leu Ile Ile Lys Leu Val 
     610                615                620
Thr Ser Ile Gly Asp Val Val Asn His Asp Pro Val Val Gly Asp Arg 
 625                630                635                640
Leu Lys Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu Lys 
                 645                650                655
Val Ile Pro Ala Ala Asp Leu Ser Gln Gln Ile Ser Thr Ala Gly Thr 
             660                665                670
Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala Leu 
         675                680                685
Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu Ala 
     690                695                700
Gly Ala Glu Asn Leu Phe Ile Phe Gly Leu Arg Val Glu Asp Val Glu 
 705                710                715                720
Ala Leu Asp Arg Lys Gly Tyr Asn Ala Arg Glu Tyr Tyr Asp His Leu 
                 725                730                735
Pro Glu Leu Lys Gln Ala Val Asp Gln Ile Ser Ser Gly Phe Phe Ser 
             740                745                750
Pro Lys Glu Pro Asp Cys Phe Lys Asp Ile Val Asn Met Leu Met His 
         755                760                765
His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Ala Tyr Met Gln Cys 
     770                775                780
Gln Ala Gln Val Asp Gln Leu Tyr Arg Asn Pro Lys Glu Trp Thr Lys 
 785                790                795                800
Lys Val Ile Arg Asn Ile Ala Cys Ser Gly Lys Phe Ser Ser Asp Arg 
                 805                810                815
Thr Ile Thr Glu Tyr Ala Arg Glu Ile Trp Gly Val Glu Pro Ser Asp 
             820                825                830
Leu Gln Ile Pro Pro Pro Asn Ile Pro Arg Asp 
         835                840



<210> 3570
<211> 484
<212> DNA
<213> Rattus norvegicus
<308> M27726
<400> 3570

cggatccat  agtacaagc  gcagctgct  aactgctta  acatcatca  cctgtacaa  60
cgaataaag  aggatccaa  caagacctt  gtgcccagg  ctgttatga  cggaggcaa  120
gcagctcct  gttaccaca  ggctaagat  atcatcaag  tggtcacat  cattggaga  180
gttgtcaat  atgatccag  tgtgggcga  aggctcaga  tgatcttcc  ggagaacta  240
cgtgtgtct  tagctgaga  agtgatccc  gccgccgac  tgtcacagc  gatctccac  300
gcgggcacc  aggcctcgg  caccggcaa  atgaagttc  tgctcaacg  agctctcac  360
atcggcacc  tggatggtg  caacgtgga  atggccgag  aggccgggg  ggagaacct  420
ttcatcttt  gtatgcggg  ggaagatgt  gaggccttg  accagaaag  gtacaatgc  480
caga  484



<210> 3571
<211> 838
<212> PRT
<213> Rattus norvegicus
<308> AAA40815
<400> 3571

Met Ala Lys Pro Leu Thr Asp Ser Glu Arg Gln Lys Gln Ile Ser Val 
  1               5                  10                  15
Arg Gly Ile Ala Gly Leu Gly Asp Val Ala Glu Val Arg Lys Ser Phe 
             20                  25                  30
Asn Arg His Leu His Phe Thr Leu Val Lys Asp Arg Asn Val Ala Thr 
         35                  40                  45
Pro Arg Asp Tyr Phe Phe Ala Leu Ala His Thr Val Arg Asp His Leu 
     50                  55                  60
Val Gly Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Glu Arg Asp Pro 
 65                  70                  75                  80
Lys Arg Ile Tyr Tyr Leu Ser Leu Glu Phe Tyr Met Gly Arg Thr Leu 
                 85                  90                  95
Gln Asn Thr Met Val Asn Leu Gly Leu Gln Thr Ala Cys Asp Glu Ala 
             100                105                110
Thr Tyr Gln Leu Gly Leu Asp Leu Glu Glu Leu Glu Glu Ile Glu Glu 
         115                120                125
Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe 
     130                135                140
Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile 
 145                150                155                160
Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile Val Asn Gly Trp Gln 
                 165                170                175
Val Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys 
             180                185                190
Ala Arg Pro Glu Tyr Met Leu Pro Val His Phe Tyr Gly Arg Val Glu 
         195                200                205
His Thr Pro Asn Gly Val Leu Trp Leu Asp Thr Gln Val Val Leu Ala 
     210                215                220
Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Lys Asn Asn Thr Val Asn 
 225                230                235                240
Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Asn Asp Phe Lys Leu Lys 
                 245                250                255
Asp Phe Asn Val Gly Asp Tyr Ile Glu Ala Val Leu Asp Arg Asn Leu 
             260                265                270
Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Asn Phe Phe Glu 
         275                280                285
Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr 
     290                295                300
Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser Lys Phe Gly Cys Arg 
 305                310                315                320
Asp Pro Val Arg Thr Cys Phe Glu Thr Phe Pro Asp Lys Val Ala Ile 
                 325                330                335
Gln Leu Asn Asp Thr His Pro Ala Leu Ser Ile Pro Glu Leu Met Arg 
             340                345                350
Ile Leu Val Asp Val Glu Lys Val Asp Trp Asp Lys Ala Trp Glu Ile 
         355                360                365
Thr Lys Lys Thr Cys Ala Tyr Thr Asn His Thr Val Leu Pro Glu Ala 
     370                375                380
Leu Glu Arg Trp Pro Val Ser Met Phe Glu Lys Leu Leu Pro Arg His 
 385                390                395                400
Leu Glu Ile Ile Tyr Ala Ile Asn Gln Arg His Leu Asp His Val Ala 
                 405                410                415
Ala Leu Phe Pro Gly Asp Val Asp Arg Leu Arg Arg Met Ser Val Ile 
             420                425                430
Glu Glu Gly Asp Cys Lys Arg Ile Asn Met Ala His Leu Cys Val Ile 
         435                440                445
Gly Ser His Ala Val Asn Gly Val Ala Arg Ile His Ser Glu Ile Val 
     450                455                460
Lys Gln Ser Val Phe Lys Asp Phe Tyr Glu Leu Glu Pro Glu Lys Phe 
 465                470                475                480
Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Leu Leu Cys 
                 485                490                495
Asn Pro Gly Leu Ala Glu Ile Ile Val Glu Arg Ile Gly Glu Gly Phe 
             500                505                510
Leu Thr Asp Leu Ser Gln Leu Lys Lys Leu Leu Ser Leu Val Asp Asp 
         515                520                525
Glu Ala Phe Ile Arg Asp Val Ala Lys Val Lys Gln Glu Asn Lys Leu 
     530                535                540
Lys Phe Ser Ala Gln Leu Glu Lys Glu Tyr Lys Val Lys Ile Asn Pro 
 545                550                555                560
Cys Ser Met Phe Asp Val His Val Lys Arg Ile His Glu Tyr Lys Arg 
                 565                570                575
Gln Leu Leu Asn Cys Leu His Ile Ile Thr Leu Tyr Asn Arg Ile Lys 
             580                585                590
Lys Asp Pro Thr Lys Thr Phe Val Pro Arg Thr Val Met Ile Gly Gly 
         595                600                605
Lys Ala Ala Pro Gly Tyr His Met Ala Lys Met Ile Ile Lys Leu Val 
     610                615                620
Thr Ser Ile Gly Asp Val Val Asn His Asp Pro Val Val Gly Asp Arg 
 625                630                635                640
Leu Arg Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu Lys 
                 645                650                655
Val Ile Pro Ala Ala Asp Leu Ser Gln Gln Ile Ser Thr Ala Gly Thr 
             660                665                670
Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala Leu 
         675                680                685
Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu Ala 
     690                695                700
Gly Glu Glu Asn Leu Phe Ile Phe Gly Met Arg Val Glu Asp Val Glu 
 705                710                715                720
Ala Leu Asp Gln Lys Gly Tyr Asn Ala Gln Glu Phe Tyr Glu Arg Leu 
                 725                730                735
Pro Glu Leu Arg Gln Ala Val Asp Gln Ile Ser Ser Gly Phe Phe Ser 
             740                745                750
Pro Lys Asp Pro Asp Cys Phe Lys Asp Val Val Asn Met Leu Met Tyr 
         755                760                765
His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Ala Tyr Ile Gln Cys 
     770                775                780
Gln Ala Gln Val Asp His Leu Tyr Arg Asn Pro Lys Asp Trp Thr Lys 
 785                790                795                800
Lys Val Ile Arg Asn Ile Ala Cys Ser Gly Lys Phe Ser Ser Asp Arg 
                 805                810                815
Thr Ile Thr Glu Tyr Ala Arg Glu Ile Trp Gly Val Glu Pro Ser Asp 
             820                825                830
Leu Gln Ile Pro Pro Pro 
         835



<210> 3572
<211> 3816
<212> DNA
<213> Homo sapiens
<308> J03544
<400> 3572

gagcagctg  accatcccg  cgttcgcgt  tgccgccgc  ttcctcctc  atctctttt  60
ctccgcctc  gccggcgcg  tgggcgaac  gctgacgga  agcgagaag  ggaagcaga  120
cagcgtgcg  ggcctggcg  ggctaggcg  cgtggccga  gtgcggaag  gcttcaacc  180
gcacttgca  ttcacgctg  tcaaggacc  caatgtggc  acgccccgc  actacttct  240
cgcgctggc  cacacggtg  gcgaccacc  cgtgggccg  tggatccgc  cgcagcagc  300
ctactacga  cgcgacccc  agcgaattt  ttatctttc  ctggaattc  acatgggtc  360
cacgctgca  aacacgatg  tgaacctgg  ccttcagaa  gcctgcgat  aagccatct  420
tcagttggg  ttagacttg  aggaactcg  ggagataga  gaagatgct  gccttggga  480
tggaggcct  gggaggctg  cagcgtgtt  ccttgactc  atggctacc  tgggcctgg  540
agcatacgg  tatggaatc  gctatgaat  tgggatttt  aaccagaag  ttgtcaatg  600
ctggcaggt  gaggaggcc  atgactggc  gcgctacgg  aacccctgg  agaaagcgc  660
gcctgagta  atgcttccc  tgcacttct  cggacgcgt  gagcacacc  ccgacggcg  720
gaagtggct  gacacacag  tggtgctgg  catgcccta  gacacccca  tgcccggct  780
caagaacaa  accgtcaac  ccatgcggc  gtggtccgc  agggctccc  acgacttca  840
gctgcagga  ttcaacgtg  gagactaca  cgaggcggt  ctggaccgg  acttggctg  900
gaacatctc  agggtcctg  atccaaatg  taacttctt  gaggggaag  agctgcggc  960
gaagcagga  tacttcgtg  tgggcgcca  gctccagga  atcatccgc  gcttcaagt  1020
gtccaagtt  ggctgccgg  accctgtga  aacctgttt  gagacgttc  cagacaagg  1080
ggccatcca  ctgaacgac  cccaccccg  cctctccat  cctgagctc  tgcggatcc  1140
ggtggacgt  gagaaggtg  actgggaca  ggcctggga  atcacgaag  agacctgtg  1200
atacaccaa  cacactgtg  tgcctgagg  cttggagcg  tggcccgtg  ccatgtttg  1260
gaagctgct  ccgcggcac  tggagataa  ctatgccat  aaccagcgg  acctggacc  1320
cgtggccgc  ctgtttccc  gcgatgtgg  ccgcctgcg  aggatgtct  tgatcgagg  1380
gggggactg  aagcggatc  acatggccc  cctgtgtgt  attgggtcc  atgctgtca  1440
tggtgtggc  aggatccac  cggagatcg  gaaacagtc  gtctttaag  atttttatg  1500
actggagcc  gagaagttc  agaataaga  caatggcat  accccccgc  ggtggctgc  1560
gctgtgcaa  ccggggctg  ccgatacca  cgtggagaa  attggggag  agttcctga  1620
tgacctgag  cagctgaag  agctgctgc  gctggtcag  gacgaggtg  tcatcaggg  1680
cgtggccaa  gtcaaacag  agaacaagc  caagttctc  gccttcctg  agaaggagt  1740
caaggtgaa  atcaacccc  cctccatgt  cgatgtgca  gtgaagagg  tccacgagt  1800
caagcggca  ctgctcaac  gcctgcacg  cgtcaccct  tacaatcga  tcaagagag  1860
cccggccaa  gcttttgtg  ccaggactg  tatgattgg  ggcaaggca  cgcccggtt  1920
ccacatggc  aagctgatc  tcaagttgg  cacctccat  ggcgacgtc  tcaatcatg  1980
cccagttgt  ggtgacagg  tgaaagtga  cttcctgga  aactaccgt  tgtccttgg  2040
tgagaaagt  atcccggcc  ctgatctgt  gcagcagat  tccactgca  gcaccgagg  2100
ctcaggcac  ggcaacatg  agttcatgc  caacggggc  ctcaccatc  gcaccatgg  2160
cggcgccaa  gtggagatg  ccgaggagg  cggggccga  aacctcttc  tcttcggcc  2220
gcgggtgga  gatgtcgag  ccttggacc  gaaagggta  aatgccagg  agtactacg  2280
ccacctgcc  gagctgaag  aggccgtgg  ccagatcag  agtggcttt  tttctccca  2340
ggagccaga  tgcttcaag  acatcgtga  catgctgat  caccatgac  ggttcaagg  2400
gtttgcaga  tatgaagcc  acatgcagt  ccaggcaca  gtggaccag  tgtaccgga  2460
ccccaagga  tggaccaag  aggtcatca  gaacatcgc  tgctcgggc  agttctcca  2520
tgaccggac  atcacggag  atgcacggg  gatctgggg  gtggagccc  ccgacctgc  2580
gcttcagca  ctgccccac  cagagtggg  gtcaggtgg  gccacctgc  gggctcccc  2640
agaactttg  acacatctt  ctatgtatt  gccgatggc  ttagtgttg  gcctctgga  2700
tctggggtc  gcggcagtg  ccatagtga  gcctgggaa  gagtgttac  gcagcatct  2760
gctgccagc  acagggaag  gccaagccc  atgtagccc  agtcatcct  cccagccct  2820
cctcctggc  atgccggga  gggtcggat  ctctaggca  cgcttcaca  ccccctgcc  2880
cctgccctc  gtcctggct  tgcacctgg  atatgggtc  tggaccaga  ggggctttc  2940
ctttgtagc  atccaatgg  cattgtgtg  gtgcttgga  cccgggatg  ctgaggggg  3000
cactggagt  ggtgcttgt  tctgctgtc  cagaggcct  ggtcaggat  aagttggct  3060
acacagctt  gcttggttt  gcttattca  aagagaaaa  aactacaca  ggaaatgaa  3120
ctagtgaag  cttttcttg  tttagaatg  aaattgtac  tggtcactt  tgtgcttga  3180
gaggcccat  ttctagcct  gcaggggca  gtcctgtgc  ctcccgctt  actcctgct  3240
tgtcctgag  tgcatttcc  gtttgttac  cacaagggc  aggctccat  ctccctccc  3300
ttccaccag  gccacagcc  cgtctggaa  aaggaccag  ggtcccgga  gaacccatt  3360
gtgctctgc  tggacagca  gcctggcac  gggaggtgg  gtgagcccc  cacagcctt  3420
cccctcccc  aggctcgaa  ctgcctccc  ttgcccaag  gagaggggc  gggaacagg  3480
tactgtcct  ccctgtgga  ttgccgaga  atctagcac  ttgcatgct  gatctgggc  3540
gcggggagg  tctttttct  cctggcctc  agtgcccac  aggaggatc  gcgcacggt  3600
cacagccca  cagagcact  cagcctttt  ttgagtggg  caagtgctg  gctgtggtc  3660
tgccctgac  gcatcttcc  caggcagcg  ctctgtgga  gaggccata  tcccctagt  3720
ggccactgg  gccaccacc  tgaccacca  tgtgcccct  attgttact  ccttgtgag  3780
taaaaactg  ttaaacctt  gtggctttg  ttggtt  3816



<210> 3573
<211> 843
<212> PRT
<213> Homo sapiens
<308> P11216
<400> 3573

Met Ala Lys Pro Leu Thr Asp Ser Glu Lys Arg Lys Gln Ile Ser Val 
  1               5                  10                  15
Arg Gly Leu Ala Gly Leu Gly Asp Val Ala Glu Val Arg Lys Ser Phe 
             20                  25                  30
Asn Arg His Leu His Phe Thr Leu Val Lys Asp Arg Asn Val Ala Thr 
         35                  40                  45
Pro Arg Asp Tyr Phe Phe Ala Leu Ala His Thr Val Arg Asp His Leu 
     50                  55                  60
Val Gly Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Glu Arg Asp Pro 
 65                  70                  75                  80
Lys Arg Ile Tyr Tyr Leu Ser Leu Glu Phe Tyr Met Gly Arg Thr Leu 
                 85                  90                  95
Gln Asn Thr Met Val Asn Leu Gly Leu Gln Asn Ala Cys Asp Glu Ala 
             100                105                110
Ile Tyr Gln Leu Gly Leu Asp Leu Glu Glu Leu Glu Glu Ile Glu Glu 
         115                120                125
Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe 
     130                135                140
Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile 
 145                150                155                160
Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile Val Asn Gly Trp Gln 
                 165                170                175
Val Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys 
             180                185                190
Ala Arg Pro Glu Tyr Met Leu Pro Val His Phe Tyr Gly Arg Val Glu 
         195                200                205
His Thr Pro Asp Gly Val Lys Trp Leu Asp Thr Gln Val Val Leu Ala 
     210                215                220
Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Lys Asn Asn Thr Val Asn 
 225                230                235                240
Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Asn Asp Phe Lys Leu Gln 
                 245                250                255
Asp Phe Asn Val Gly Asp Tyr Ile Glu Ala Val Leu Asp Arg Asn Leu 
             260                265                270
Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Asn Phe Phe Glu 
         275                280                285
Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr 
     290                295                300
Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser Lys Phe Gly Cys Arg 
 305                310                315                320
Asp Pro Val Arg Thr Cys Phe Glu Thr Phe Pro Asp Lys Val Ala Ile 
                 325                330                335
Gln Leu Asn Asp Thr His Pro Ala Leu Ser Ile Pro Glu Leu Met Arg 
             340                345                350
Ile Leu Val Asp Val Glu Lys Val Asp Trp Asp Lys Ala Trp Glu Ile 
         355                360                365
Thr Lys Lys Thr Cys Ala Tyr Thr Asn His Thr Val Leu Pro Glu Ala 
     370                375                380
Leu Glu Arg Trp Pro Val Ser Met Phe Glu Lys Leu Leu Pro Arg His 
 385                390                395                400
Leu Glu Ile Ile Tyr Ala Ile Asn Gln Arg His Leu Asp His Val Ala 
                 405                410                415
Ala Leu Phe Pro Gly Asp Val Asp Arg Leu Arg Arg Met Ser Val Ile 
             420                425                430
Glu Glu Gly Asp Cys Lys Arg Ile Asn Met Ala His Leu Cys Val Ile 
         435                440                445
Gly Ser His Ala Val Asn Gly Val Ala Arg Ile His Ser Glu Ile Val 
     450                455                460
Lys Gln Ser Val Phe Lys Asp Phe Tyr Glu Leu Glu Pro Glu Lys Phe 
 465                470                475                480
Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Leu Leu Cys 
                 485                490                495
Asn Pro Gly Leu Ala Asp Thr Ile Val Glu Lys Ile Gly Glu Glu Phe 
             500                505                510
Leu Thr Asp Leu Ser Gln Leu Lys Lys Leu Leu Pro Leu Val Ser Asp 
         515                520                525
Glu Val Phe Ile Arg Asp Val Ala Lys Val Lys Gln Glu Asn Lys Leu 
     530                535                540
Lys Phe Ser Ala Phe Leu Glu Lys Glu Tyr Lys Val Lys Ile Asn Pro 
 545                550                555                560
Ser Ser Met Phe Asp Val His Val Lys Arg Ile His Glu Tyr Lys Arg 
                 565                570                575
Gln Leu Leu Asn Cys Leu His Val Val Thr Leu Tyr Asn Arg Ile Lys 
             580                585                590
Arg Asp Pro Ala Lys Ala Phe Val Pro Arg Thr Val Met Ile Gly Gly 
         595                600                605
Lys Ala Ala Pro Gly Tyr His Met Ala Lys Leu Ile Ile Lys Leu Val 
     610                615                620
Thr Ser Ile Gly Asp Val Val Asn His Asp Pro Val Val Gly Asp Arg 
 625                630                635                640
Leu Lys Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu Lys 
                 645                650                655
Val Ile Pro Ala Ala Asp Leu Ser Gln Gln Ile Ser Thr Ala Gly Thr 
             660                665                670
Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala Leu 
         675                680                685
Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu Ala 
     690                695                700
Gly Ala Glu Asn Leu Phe Ile Phe Gly Leu Arg Val Glu Asp Val Glu 
 705                710                715                720
Ala Leu Asp Arg Lys Gly Tyr Asn Ala Arg Glu Tyr Tyr Asp His Leu 
                 725                730                735
Pro Glu Leu Lys Gln Ala Val Asp Gln Ile Ser Ser Gly Phe Phe Ser 
             740                745                750
Pro Lys Glu Pro Asp Cys Phe Lys Asp Ile Val Asn Met Leu Met His 
         755                760                765
His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Ala Tyr Met Gln Cys 
     770                775                780
Gln Ala Gln Val Asp Gln Leu Tyr Arg Asn Pro Lys Glu Trp Thr Lys 
 785                790                795                800
Lys Val Ile Arg Asn Ile Ala Cys Ser Gly Lys Phe Ser Ser Asp Arg 
                 805                810                815
Thr Ile Thr Glu Tyr Ala Arg Glu Ile Trp Gly Val Glu Pro Ser Asp 
             820                825                830
Leu Gln Ile Pro Pro Pro Asn Ile Pro Arg Asp 
         835                840



<210> 3575
<211> 704
<212> PRT
<213> Rattus norvegicus
<308> P09951
<400> 3575

Met Asn Tyr Leu Arg Arg Arg Leu Ser Asp Ser Asn Phe Met Ala Asn 
  1               5                  10                  15
Leu Pro Asn Gly Tyr Met Thr Asp Leu Gln Arg Pro Gln Pro Pro Pro 
             20                  25                  30
Pro Pro Pro Ser Ala Ala Ser Pro Gly Ala Thr Pro Gly Ser Ala Ala 
         35                  40                  45
Ala Ser Ala Glu Arg Ala Ser Thr Ala Ala Pro Val Ala Ser Pro Ala 
     50                  55                  60
Ala Pro Ser Pro Gly Ser Ser Gly Gly Gly Gly Phe Phe Ser Ser Leu 
 65                  70                  75                  80
Ser Asn Ala Val Lys Gln Thr Thr Ala Ala Ala Ala Ala Thr Phe Ser 
                 85                  90                  95
Glu Gln Val Gly Gly Gly Ser Gly Gly Ala Gly Arg Gly Gly Ala Ala 
             100                105                110
Ala Arg Val Leu Leu Val Ile Asp Glu Pro His Thr Asp Trp Ala Lys 
         115                120                125
Tyr Phe Lys Gly Lys Lys Ile His Gly Glu Ile Asp Ile Lys Val Glu 
     130                135                140
Gln Ala Glu Phe Ser Asp Leu Asn Leu Val Ala His Ala Asn Gly Gly 
 145                150                155                160
Phe Ser Val Asp Met Glu Val Leu Arg Asn Gly Val Lys Val Val Arg 
                 165                170                175
Ser Leu Lys Pro Asp Phe Val Leu Ile Arg Gln His Ala Phe Ser Met 
             180                185                190
Ala Arg Asn Gly Asp Tyr Arg Ser Leu Val Ile Gly Leu Gln Tyr Ala 
         195                200                205
Gly Ile Pro Ser Val Asn Ser Leu His Ser Val Tyr Asn Phe Cys Asp 
     210                215                220
Lys Pro Trp Val Phe Ala Gln Met Val Arg Leu His Lys Lys Leu Gly 
 225                230                235                240
Thr Glu Glu Phe Pro Leu Ile Asp Gln Thr Phe Tyr Pro Asn His Lys 
                 245                250                255
Glu Met Leu Ser Ser Thr Thr Tyr Pro Val Val Val Lys Met Gly His 
             260                265                270
Ala His Ser Gly Met Gly Lys Val Lys Val Asp Asn Gln His Asp Phe 
         275                280                285
Gln Asp Ile Ala Ser Val Val Ala Leu Thr Lys Thr Tyr Ala Thr Ala 
     290                295                300
Glu Pro Phe Ile Asp Ala Lys Tyr Asp Val Arg Val Gln Lys Ile Gly 
 305                310                315                320
Gln Asn Tyr Lys Ala Tyr Met Arg Thr Ser Val Ser Gly Asn Trp Lys 
                 325                330                335
Thr Asn Thr Gly Ser Ala Met Leu Glu Gln Ile Ala Met Ser Asp Arg 
             340                345                350
Tyr Lys Leu Trp Val Asp Thr Cys Ser Glu Ile Phe Gly Gly Leu Asp 
         355                360                365
Ile Cys Ala Val Glu Ala Leu His Gly Lys Asp Gly Arg Asp His Ile 
     370                375                380
Ile Glu Val Val Gly Ser Ser Met Pro Leu Ile Gly Asp His Gln Asp 
 385                390                395                400
Glu Asp Lys Gln Leu Ile Val Glu Leu Val Val Asn Lys Met Thr Gln 
                 405                410                415
Ala Leu Pro Arg Gln Arg Asp Ala Ser Pro Gly Arg Gly Ser His Ser 
             420                425                430
Gln Thr Pro Ser Pro Gly Ala Leu Pro Leu Gly Arg Gln Thr Ser Gln 
         435                440                445
Gln Pro Ala Gly Pro Pro Ala Gln Gln Arg Pro Pro Pro Gln Gly Gly 
     450                455                460
Pro Pro Gln Pro Gly Pro Gly Pro Gln Arg Gln Gly Pro Pro Leu Gln 
 465                470                475                480
Gln Arg Pro Pro Pro Gln Gly Gln Gln His Leu Ser Gly Leu Gly Pro 
                 485                490                495
Pro Ala Gly Ser Pro Leu Pro Gln Arg Leu Pro Ser Pro Thr Ala Ala 
             500                505                510
Pro Gln Gln Ser Ala Ser Gln Ala Thr Pro Met Thr Gln Gly Gln Gly 
         515                520                525
Arg Gln Ser Arg Pro Val Ala Gly Gly Pro Gly Ala Pro Pro Ala Ala 
     530                535                540
Arg Pro Pro Ala Ser Pro Ser Pro Gln Arg Gln Ala Gly Pro Pro Gln 
 545                550                555                560
Ala Thr Arg Gln Ala Ser Ile Ser Gly Pro Ala Pro Pro Lys Val Ser 
                 565                570                575
Gly Ala Ser Pro Gly Gly Gln Gln Arg Gln Gly Pro Pro Gln Lys Pro 
             580                585                590
Pro Gly Pro Ala Gly Pro Ile Arg Gln Ala Ser Gln Ala Gly Pro Gly 
         595                600                605
Pro Arg Thr Gly Pro Pro Thr Thr Gln Gln Pro Arg Pro Ser Gly Pro 
     610                615                620
Gly Pro Ala Gly Arg Pro Thr Lys Pro Gln Leu Ala Gln Lys Pro Ser 
 625                630                635                640
Gln Asp Val Pro Pro Pro Ile Ile Ala Ala Ala Gly Gly Pro Pro His 
                 645                650                655
Pro Gln Leu Asn Lys Ser Gln Ser Leu Thr Asn Ala Phe Asn Leu Pro 
             660                665                670
Glu Pro Ala Pro Pro Arg Pro Ser Leu Ser Gln Asp Glu Val Lys Ala 
         675                680                685
Glu Thr Ile Arg Ser Leu Arg Lys Ser Phe Ala Ser Leu Phe Ser Asp 
     690                695                700



<210> 3576
<211> 2648
<212> DNA
<213> Rattus norvegicus
<308> M27925
<400> 3576

gctggggag  cccagagcg  cgcgctgtc  gctgggctc  cggagacgc  gaccacctt  60
ggtcgcccc  cgccgtcct  tccgcgccg  ctggcccgc  gcctcgagc  ccctcagtc  120
ctcaagcca  atgatgaac  tcctgaggc  ccggctgtc  gacagcagc  tcattgcca  180
cctgcccaa  ggctacatg  ctgaccttc  gcgcccgga  ccgcagcag  ccccacccg  240
ccctggccc  ggtaccgct  ccgcgtcgg  ggccacctc  gctgcctcg  ctggccccg  300
gcgcaggcc  ccacccgcc  aggcacccg  gccgcagcc  gcgccgcag  ccgcgccga  360
gccgtcggt  ggcagcagc  tcttcagct  gctgtcgca  gccgtgaag  agacggccg  420
ctccgccgg  ctggtggac  cgcccgcgc  ttcggccgc  tccaggaag  ccaaggtgc  480
gctggtggt  gacgagccg  acaccgact  ggccaagtg  tttcggggc  aaaaaatcc  540
tggagatta  gacatcaaa  tagaacagg  agaattttc  gagcttaac  tggtggccc  600
tgcggatgg  acctacgcc  tggacatgc  ggtactccg  aatggcaca  aggttgtca  660
gtccttcag  ccagacttc  tgctcatcc  acagcatgc  tttggcatg  cggagaatg  720
agacttccg  cacctggtc  ttggcatgc  gtatgcagg  ctccccagc  tcaactcac  780
ggagtccat  tacaacttc  gtgacaagc  atgggtgtt  gctcagatg  tggccatct  840
caagacact  ggaggggag  aatttccac  cattgagca  acctactac  ccaatcacc  900
agagatgct  acacttcct  cgtttcctg  cgtggtgaa  attggccat  ctcactcgg  960
catgggcaa  gtcaaagtg  aaaatcact  cgacttcca  gacattgcc  gtgtggtgg  1020
cctcaccca  acctatgcc  cagcagaac  cttcattga  gccaagtat  acatccggg  1080
tcagaagat  ggcaacaac  acaaggctt  catgaggac  tccatctca  ggaactgga  1140
gacaaacac  ggctccgcg  tgctggagc  gatcgccat  tcagaccgg  acaagctct  1200
ggtcgacgc  tgctctgag  tgtttgggg  cttggacat  tgtgcagtc  aagctgtgc  1260
tggcaaaga  ggcaaagac  acatttttg  ggtcatgga  tgtagcatg  cactgattg  1320
ggaacacca  gtggaggac  gacaactca  cactgatct  gtcatcagc  agatgaacc  1380
gctattgtc  aggactcct  ccctgtctc  acagagacc  ttaaccacc  aacagccac  1440
gagtggaac  cttaaggaa  cggactcca  caagacccc  cctcagcgg  cagcccccc  1500
agggggccc  gggcaaccc  aaggaatgc  gcccccagg  aaggtgctg  ctccacgtc  1560
gctcccctc  ggaccatca  tgccacctt  ttcctcttc  tcctcctct  cctcctcct  1620
ttcctcggc  cctcagagg  cgggcggcc  tacctccac  caggtgaat  catcctcca  1680
cagcaactc  ctggcagag  cccaggcac  tcaggctgc  ccaccacag  agccccagc  1740
tcacccaca  ctcaacaag  cgcagtccc  gacaaatgc  ttcagcttc  ctgagtcct  1800
cttcttccg  tcttcagcc  atgaagatg  agccaaagc  gagaccatc  ggagcttga  1860
gaagtcctt  gccagcctc  tttcagatt  gctcttcag  tacacgagg  catccggcc  1920
aaccaggaa  ggcatctaa  acattcatc  acagcagtc  gccatgttt  gtggcaatg  1980
cccatgact  ggacatgtg  ggccccttc  tctgttcct  tgtgctcag  aatttgtgc  2040
gcccagaaa  gaccatgtg  tggtctcag  gcaggtggc  accctgaga  agacctgac  2100
gtagaggaa  gggctgttt  cctgtagtc  taagagctt  attctgaag  catcgttgc  2160
gtgaattca  tggccttat  gtgacagag  catcgtgtc  tactcttcc  tgtgaagcc  2220
ggatctctg  aacgtagga  tcctggcag  ttacctatc  cagcatatc  tagtagtca  2280
tgctacctg  gggaaatat  ttcttacct  agaagtatt  ttggctcta  gttttagga  2340
cttctcccc  aagctgggt  tcctgtggt  cctgttgaa  gcacattca  ctgaccctg  2400
actccctag  ctgctgtgg  ggtcaagtt  cttgtgact  tttgaaaca  gagaacaag  2460
atccacagt  tctcctttc  cccctctgg  gagcagttc  gttgtgtga  catcagtaa  2520
cttgacctt  cgaagctgt  ctgtagaag  gaatgcatg  cgctataac  gcagtccac  2580
aacctttgt  ttcctcacc  tatgaatgt  aagaccttg  tgtaataaa  gcagcagct  2640
taaccagc  2648



<210> 3577
<211> 586
<212> PRT
<213> Rattus norvegicus
<308> Q63537
<400> 3577

Met Met Asn Phe Leu Arg Arg Arg Leu Ser Asp Ser Ser Phe Ile Ala 
  1               5                  10                  15
Asn Leu Pro Asn Gly Tyr Met Thr Asp Leu Gln Arg Pro Glu Pro Gln 
             20                  25                  30
Gln Pro Pro Pro Ala Pro Gly Pro Gly Thr Ala Thr Ala Ser Ala Ala 
         35                  40                  45
Thr Ser Ala Ala Ser Pro Gly Pro Glu Arg Arg Pro Pro Pro Ala Gln 
     50                  55                  60
Ala Pro Ala Pro Gln Pro Ala Pro Gln Pro Ala Pro Thr Pro Ser Val 
 65                  70                  75                  80
Gly Ser Ser Phe Phe Ser Ser Leu Ser Gln Ala Val Lys Gln Thr Ala 
                 85                  90                  95
Ala Ser Ala Gly Leu Val Asp Ala Pro Ala Pro Ser Ala Ala Ser Arg 
             100                105                110
Lys Ala Lys Val Leu Leu Val Val Asp Glu Pro His Thr Asp Trp Ala 
         115                120                125
Lys Cys Phe Arg Gly Lys Lys Ile Leu Gly Asp Tyr Asp Ile Lys Val 
     130                135                140
Glu Gln Ala Glu Phe Ser Glu Leu Asn Leu Val Ala His Ala Asp Gly 
 145                150                155                160
Thr Tyr Ala Val Asp Met Gln Val Leu Arg Asn Gly Thr Lys Val Val 
                 165                170                175
Arg Ser Phe Arg Pro Asp Phe Val Leu Ile Arg Gln His Ala Phe Gly 
             180                185                190
Met Ala Glu Asn Glu Asp Phe Arg His Leu Val Ile Gly Met Gln Tyr 
         195                200                205
Ala Gly Leu Pro Ser Ile Asn Ser Leu Glu Ser Ile Tyr Asn Phe Cys 
     210                215                220
Asp Lys Pro Trp Val Phe Ala Gln Met Val Ala Ile Phe Lys Thr Leu 
 225                230                235                240
Gly Gly Glu Lys Phe Pro Leu Ile Glu Gln Thr Tyr Tyr Pro Asn His 
                 245                250                255
Arg Glu Met Leu Thr Leu Pro Thr Phe Pro Val Val Val Lys Ile Gly 
             260                265                270
His Ala His Ser Gly Met Gly Lys Val Lys Val Glu Asn His Tyr Asp 
         275                280                285
Phe Gln Asp Ile Ala Ser Val Val Ala Leu Thr Gln Thr Tyr Ala Thr 
     290                295                300
Ala Glu Pro Phe Ile Asp Ala Lys Tyr Asp Ile Arg Val Gln Lys Ile 
 305                310                315                320
Gly Asn Asn Tyr Lys Ala Tyr Met Arg Thr Ser Ile Ser Gly Asn Trp 
                 325                330                335
Lys Thr Asn Thr Gly Ser Ala Met Leu Glu Gln Ile Ala Met Ser Asp 
             340                345                350
Arg Tyr Lys Leu Trp Val Asp Ala Cys Ser Glu Met Phe Gly Gly Leu 
         355                360                365
Asp Ile Cys Ala Val Lys Ala Val His Gly Lys Asp Gly Lys Asp Tyr 
     370                375                380
Ile Phe Glu Val Met Asp Cys Ser Met Pro Leu Ile Gly Glu His Gln 
 385                390                395                400
Val Glu Asp Arg Gln Leu Ile Thr Asp Leu Val Ile Ser Lys Met Asn 
                 405                410                415
Gln Leu Leu Ser Arg Thr Pro Ala Leu Ser Pro Gln Arg Pro Leu Thr 
             420                425                430
Thr Gln Gln Pro Gln Ser Gly Thr Leu Lys Glu Pro Asp Ser Ser Lys 
         435                440                445
Thr Pro Pro Gln Arg Pro Ala Pro Gln Gly Gly Pro Gly Gln Pro Gln 
     450                455                460
Gly Met Gln Pro Pro Gly Lys Val Leu Pro Pro Arg Arg Leu Pro Ser 
 465                470                475                480
Gly Pro Ser Leu Pro Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                 485                490                495
Ser Ser Ser Ala Pro Gln Arg Pro Gly Gly Pro Thr Ser Thr Gln Val 
             500                505                510
Asn Ala Ser Ser Ser Ser Asn Ser Leu Ala Glu Pro Gln Ala Pro Gln 
         515                520                525
Ala Ala Pro Pro Gln Lys Pro Gln Pro His Pro Gln Leu Asn Lys Ser 
     530                535                540
Gln Ser Leu Thr Asn Ala Phe Ser Phe Ser Glu Ser Ser Phe Phe Arg 
 545                550                555                560
Ser Ser Ala Asn Glu Asp Glu Ala Lys Ala Glu Thr Ile Arg Ser Leu 
                 565                570                575
Arg Lys Ser Phe Ala Ser Leu Phe Ser Asp 
             580                585



<210> 3578
<211> 2074
<212> DNA
<213> Homo sapiens
<308> U40215
<400> 3578

ctccctccg  gccaccaga  cccgtagcc  cgcgcgccc  cagcccttt  agccagatg  60
tgaacttcc  gcggcgccg  ctgtcggac  gcagcttca  cgccaacct  cccaacggc  120
acatgaccg  cctgcagcg  cccgagccc  agcagccgc  gccgccgcc  ccccccggt  180
cgggcgccg  ctcggcctc  gcggcgccc  cgaccgcct  gccgggccc  gagcggagg  240
cgccgcccg  ctcggcgcc  gccgcgcag  ccgcgccga  gccgtcggt  ggcagcagc  300
tcttcagct  gctgtccca  gccgtgaag  agacggccg  ctcggctgg  ctggtggac  360
cgcccgctc  cgcgcccgc  gccgccagg  aggccaagg  gctgctggt  gtcgacgag  420
cgcacgccg  ctgggccaa  tgctttcgg  gcaaaaaag  ccttggaga  tatgatatc  480
aggtggaac  ggcagaatt  tcagagctc  acctggtgg  ccatgcaga  ggcacctat  540
ctgtggata  gcaggttct  cggaatggc  caaaggttg  ccggtcctt  cggccagac  600
tcgtgctca  ccggcagca  gcatttggc  tggcggaga  tgaggactt  cgccacctg  660
tcattggta  gcagtatgc  ggcctcccc  gcatcaact  actggaatc  atatacaac  720
tctgtgaca  gccatgggt  tttgcccag  tggtcgcta  ctataagac  ctgggagga  780
aaaagttcc  tctcattga  cagacatac  accccaacc  caaagagat  ctgacactg  840
ccacgttcc  tgtggtggt  aagattggc  acgctcact  aggcatggg  aaggtcaaa  900
tggaaaacc  ctacgactt  caggacatt  ccagcgtgg  ggctctcac  cagacctat  960
ccactgcag  gcctttcat  gactccaag  atgacatcc  ggtccagaa  attggcaac  1020
actacaagg  ttatatgag  acatcgatc  cagggaact  gaagacgaa  actggctct  1080
cgatgctgg  gcagattgc  atgtcagac  ggtacaaac  gtgggtgga  acctgctct  1140
agatgtttg  cggcctgga  atctgtgct  tcaaagctg  acatggcaa  gatgggaaa  1200
actacattt  tgaggtcat  gactgtagc  tgccactga  tggggaaca  caggtggag  1260
acaggcaac  catcaccga  ctagtcatc  gcaagatga  ccagctgct  tccaggact  1320
ctgccctgt  tcctcagag  cccctaaca  cccagcagc  acagagcgg  acacttaag  1380
atccggact  aagcaagac  ccacctcag  ggccacccc  tcaaggttg  ttacagtat  1440
ttctcgact  taatggcat  gcagtaggg  caaaacaag  ccaagcttc  taaaatgat  1500
ggtggttaa  ttttcaaag  agaaatttt  agccaaaaa  aaacgaaag  aaagcgggg  1560
ggggaaaac  gaccctccc  ctggtgccg  tgctgcgtt  tttcaatgc  gactggact  1620
tgtttttcc  atgacgtgt  agctcctct  tctggttgt  tacctgttc  tgttcgtgc  1680
tgtaatgct  acttatgtt  tctctgtat  acttgtgat  ccagggctg  ttgtcaaca  1740
tatacaaaa  aattgtgcc  ctcccaagt  cagtgtgac  ttatcttct  ggtggtttg  1800
tagtgtttt  aaaagtaat  tataatgtg  ggtgaaatg  gagtagggg  tggacaggg  1860
agaaacgaa  accacaaaa  gaaacccaa  tcctctcct  cccaagctc  gttaaatcc  1920
ccaccttcc  aacctttcc  tccaccagt  tgcttggga  cttcaatga  ctgtgcttt  1980
gcttcttct  catgactat  ataactaga  agaacatta  gagatttca  gatcaactc  2040
atagcttct  ccactgaat  gaggcatca  cttt  2074



<210> 3579
<211> 582
<212> PRT
<213> Homo sapiens
<308> Q92777
<400> 3579

Met Met Asn Phe Leu Arg Arg Arg Leu Ser Asp Ser Ser Phe Ile Ala 
  1               5                  10                  15
Asn Leu Pro Asn Gly Tyr Met Thr Asp Leu Gln Arg Pro Glu Pro Gln 
             20                  25                  30
Gln Pro Pro Pro Pro Pro Pro Pro Gly Pro Gly Ala Ala Ser Ala Ser 
         35                  40                  45
Ala Ala Pro Pro Thr Ala Ser Pro Gly Pro Glu Arg Lys Pro Pro Pro 
     50                  55                  60
Ala Ser Ala Pro Ala Pro Gln Pro Ala Pro Thr Pro Ser Val Gly Ser 
 65                  70                  75                  80
Ser Phe Phe Ser Ser Leu Ser Gln Ala Val Lys Gln Thr Ala Ala Ser 
                 85                  90                  95
Ala Gly Leu Val Asp Ala Pro Ala Pro Ala Pro Ala Ala Ala Arg Lys 
             100                105                110
Ala Lys Val Leu Leu Val Val Asp Glu Pro His Ala Asp Trp Ala Lys 
         115                120                125
Cys Phe Arg Gly Lys Lys Val Leu Gly Asp Tyr Asp Ile Lys Val Glu 
     130                135                140
Gln Ala Glu Phe Ser Glu Leu Asn Leu Val Ala His Ala Asp Gly Thr 
 145                150                155                160
Tyr Ala Val Asp Met Gln Val Leu Arg Asn Gly Thr Lys Val Val Arg 
                 165                170                175
Ser Phe Arg Pro Asp Phe Val Leu Ile Arg Gln His Ala Phe Gly Met 
             180                185                190
Ala Glu Asn Glu Asp Phe Arg His Leu Ile Ile Gly Met Gln Tyr Ala 
         195                200                205
Gly Leu Pro Ser Ile Asn Ser Leu Glu Ser Ile Tyr Asn Phe Cys Asp 
     210                215                220
Lys Pro Trp Val Phe Ala Gln Leu Val Ala Ile Tyr Lys Thr Leu Gly 
 225                230                235                240
Gly Glu Lys Phe Pro Leu Ile Glu Gln Thr Tyr Tyr Pro Asn His Lys 
                 245                250                255
Glu Met Leu Thr Leu Pro Thr Phe Pro Val Val Val Lys Ile Gly His 
             260                265                270
Ala His Ser Gly Met Gly Lys Val Lys Val Glu Asn His Tyr Asp Phe 
         275                280                285
Gln Asp Ile Ala Ser Val Val Ala Leu Thr Gln Thr Tyr Ala Thr Ala 
     290                295                300
Glu Pro Phe Ile Asp Ser Lys Tyr Asp Ile Arg Val Gln Lys Ile Gly 
 305                310                315                320
Asn Asn Tyr Lys Ala Tyr Met Arg Thr Ser Ile Ser Gly Asn Trp Lys 
                 325                330                335
Thr Asn Thr Gly Ser Ala Met Leu Glu Gln Ile Ala Met Ser Asp Arg 
             340                345                350
Tyr Lys Leu Trp Val Asp Thr Cys Ser Glu Met Phe Gly Gly Leu Asp 
         355                360                365
Ile Cys Ala Val Lys Ala Val His Gly Lys Asp Gly Lys Asp Tyr Ile 
     370                375                380
Phe Glu Val Met Asp Cys Ser Met Pro Leu Ile Gly Glu His Gln Val 
 385                390                395                400
Glu Asp Arg Gln Leu Ile Thr Glu Leu Val Ile Ser Lys Met Asn Gln 
                 405                410                415
Leu Leu Ser Arg Thr Pro Ala Leu Ser Pro Gln Arg Pro Leu Thr Thr 
             420                425                430
Gln Gln Pro Gln Ser Gly Thr Leu Lys Asp Pro Asp Ser Ser Lys Thr 
         435                440                445
Pro Pro Gln Arg Pro Pro Pro Gln Gly Gly Pro Gly Gln Pro Gln Gly 
     450                455                460
Met Gln Pro Pro Gly Lys Val Leu Pro Pro Arg Arg Leu Pro Pro Gly 
 465                470                475                480
Pro Ser Leu Pro Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                 485                490                495
Ala Pro Gln Arg Pro Gly Gly Pro Thr Thr His Gly Asp Ala Pro Ser 
             500                505                510
Ser Ser Ser Ser Leu Ala Glu Ala Gln Pro Pro Leu Ala Ala Pro Pro 
         515                520                525
Gln Lys Pro Gln Pro His Pro Gln Leu Asn Lys Ser Gln Ser Leu Thr 
     530                535                540
Asn Ala Phe Ser Phe Ser Glu Ser Ser Phe Phe Arg Ser Ser Ala Asn 
 545                550                555                560
Glu Asp Glu Ala Lys Ala Glu Thr Ile Arg Ser Leu Arg Lys Ser Phe 
                 565                570                575
Ala Ser Leu Phe Ser Asp 
             580



<210> 3580
<211> 334
<212> DNA
<213> Rattus norvegicus
<308> M28255
<400> 3580

ggcggggtc  tggatatca  cattgggct  acttcctgc  tcgtgtgtt  tcttctacc  60
gcgggctgg  tcctgtcac  cctggaaag  tacaagaag  gggagtgaa  ggagcgtct  120
ccctcatcc  ttgactaga  cactcttgc  agcccacct  gatcatgtt  cctgcattc  180
tggctggct  acccyggga  catgttatt  aattccagt  acctcttct  caatcatga  240
ctctcgatg  ctccatggt  acaactggg  ccacatata  tggttctgc  tgatggggt  300
cccctttgt  acaataaag  ctatttaaa  cttg  334



<210> 3581
<211> 44
<212> PRT
<213> Rattus norvegicus
<308> P80433
<400> 3581

Val His Ser Lys Pro Pro Arg Glu Gln Leu Gly Val Leu Asp Ile Thr 
  1               5                  10                  15
Ile Gly Leu Thr Ser Cys Phe Val Cys Cys Leu Leu Pro Ala Gly Trp 
             20                  25                  30
Val Leu Ser His Leu Glu Ser Tyr Lys Lys Arg Glu 
         35                  40



<210> 3582
<211> 2787
<212> DNA
<213> Rattus norvegicus
<308> M28648
<400> 3582

atgaatctt  aaaaagatg  caagagctc  cccaagaag  gcaaggcca  agagcgccg  60
gacctggat  acctcaaga  ggaagtggc  atgacagag  ataaaatgt  agtagaaga  120
gtctgccgg  aatacaata  cgactgcgt  cagggtctg  cacacagta  agcccagga  180
atcctagcc  gggatgggc  taacgccct  acaccaccg  ccaccaccc  agaatgggt  240
aagttctgc  gacagctat  tggtggctt  tccatcctg  tgtggatcg  ggcgatcct  300
tgcttcctg  gctatggca  ccaggcagg  actgaggat  aaccttccg  tgacaatct  360
tacctgggc  tagtgctgg  cggtgtggt  atcatcacc  gctgcttct  ctactacca  420
gaagccaag  gctctaaga  tatgcagtc  ttcacgaac  tggttcccc  gcaagccct  480
gtgatccgg  aaggtgata  gatgcaggt  aatgcggag  aggtggtcg  cggggacct  540
gtggagatc  agggtggcg  tcgggtgcc  gctgagctg  gcatcatct  ggcccatcg  600
tgcaaggtg  acaactctt  cctgactgg  gaatctgag  ctcagaccc  ctccccgga  660
tgcacacac  acaacccat  ggagacccg  aacatcacc  tcttttcca  caactgtgt  720
gaaggcacc  ctcgtggtg  ggtggtagc  acaggtgac  gcaccgtca  gggccgcat  780
gccaccctg  cctcaggcc  ggaggtggg  aagacgccc  tcgccattg  gatcgagca  840
ttcatccag  tcatcactg  cgtggccgt  ttcctgggc  tctccttct  catcctctc  900
ctcattctg  gctacacct  gctggaggc  gtcatcttc  tcatcggta  cattgtggc  960
aatgtccca  agggcctgc  ggctactgt  acggtgtgt  tgacgctga  cgcaaggat  1020
gctcggaag  actgtctgg  aaagaacct  gaggcggtg  agacgctag  ctccacatc  1080
accatctgc  ccgacaaga  cggcaccct  acccagaac  gcatgaccg  cgcccacat  1140
tggtttgac  accagatcc  cgaggccga  actactgag  atcagtcag  gacctcttt  1200
gacaagagc  cacacacct  ggtggccct  tcccacatc  ccggtctct  caaccgggc  1260
gtctttaag  gcgggcagg  taacatccc  gtactcaag  gggacgtgg  gggtgatgc  1320
tcagagtcc  ccctgctta  gtgcatcga  ctgtcctcg  gttccgtaa  gctgatgcg  1380
gaacgaaac  agaaagtcg  cgagattcc  ttcaactcc  ctaacaaat  ccagctatc  1440
atccatgag  ctgaggacc  caatgacaa  cgatacctg  tagtgatga  gggcgcccc  1500
gaacgcatt  tggaccgct  tgcgaccat  ctcctgcag  gcaaggagc  gcctctgga  1560
gaggagatg  aggaggcct  ccagaacgc  tacctggag  ttggtggcc  gggcgagcg  1620
gtgctgggt  tctgccatt  ctacctgcc  gaggaacag  tccccaagg  ctttgcctt  1680
gactgtgat  acgtgaact  caccacaga  aacctttgc  tcgtgggtc  catgtccat  1740
atcgaccct  cccgggcag  tgtccctga  gctgttggc  aatgccgca  tgcaggcat  1800
aaggtcatc  tggtcaccg  cgatcaccc  atcactgcg  aggccatcg  caaaggtaa  1860
ggcatcatc  ccgagggta  cgagactgt  gaggacatc  ctgcccggc  caacatccc  1920
gtcagccag  tcaacccca  ggatgccaa  gcctgtgtg  ttcatggca  tgacctcaa  1980
gacttcacc  ctgagcaga  tgacgagat  ctccagaac  acactgaga  cgtctttgc  2040
cgaacctcc  ctcagcaga  gctcatcat  gtggagggc  gtcagagac  gggagcaat  2100
gtggctgtg  ctggcgatg  tgtgaatga  tcccctgct  tgaagaagg  tgatattgg  2160
gtggccatg  gcattgctg  ctctgatgt  tctaagcag  ctgccgaca  gattctgct  2220
gatgacaat  ttgcttcca  tgtcactgg  gtggaggaa  gccgcctga  ctttgacaa  2280
ctgaagaaa  ccatcgcct  cactctgac  agcaacatc  ctgagatca  acccttcct  2340
ctcttcatc  tggccaaca  cccactgcc  cttggcacc  tcaccatcc  ctgcattga  2400
ctgggcacc  acatggacc  tacaatctc  ttggcctac  aggctgcag  gagtgacat  2460
atgaagagg  agcccagga  cccacgcac  gacaaactg  tcaacgaaa  gctcatcag  2520
atggcctat  ggcagatcg  gatgatcca  gccctcgga  gtttcttct  ctactttgt  2580
atcctggca  aaaatggtt  cttgcccgg  aacctggtg  gcatccggc  caactggga  2640
gaccgcact  tcaacgacc  ggaagacag  tacgggcag  agtggactt  tgagcagag  2700
aaggtggtt  agttcacgt  ccacacagc  ttcttcgtg  gcatagtgg  ggtccagtg  2760
gctgacctg  tcatttgca  gaccagg  2787



<210> 3583
<211> 1013
<212> PRT
<213> Rattus norvegicus
<308> AAA41672
<400> 3583

Met Gly Asp Lys Lys Asp Asp Lys Ser Ser Pro Lys Lys Ser Lys Ala 
  1               5                  10                  15
Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr 
             20                  25                  30
Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp 
         35                  40                  45
Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg 
     50                  55                  60
Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val 
 65                  70                  75                  80
Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile 
                 85                  90                  95
Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu 
             100                105                110
Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala 
         115                120                125
Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser 
     130                135                140
Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu 
 145                150                155                160
Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val 
                 165                170                175
Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp 
             180                185                190
Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu 
         195                200                205
Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp 
     210                215                220
Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val 
 225                230                235                240
Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val 
                 245                250                255
Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr 
             260                265                270
Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val 
         275                280                285
Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly 
     290                295                300
Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala 
 305                310                315                320
Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Leu 
                 325                330                335
Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu 
             340                345                350
Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr 
         355                360                365
Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp 
     370                375                380
Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser 
 385                390                395                400
Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly 
                 405                410                415
Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val 
             420                425                430
Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys 
         435                440                445
Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn 
     450                455                460
Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu 
 465                470                475                480
Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val 
                 485                490                495
Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ala Thr Ile Leu 
             500                505                510
Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe 
         515                520                525
Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly 
     530                535                540
Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala 
 545                550                555                560
Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val 
                 565                570                575
Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
             580                585                590
Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
         595                600                605
Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
     610                615                620
Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile 
 625                630                635                640
Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His 
                 645                650                655
Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu 
             660                665                670
Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
         675                680                685
Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val 
     690                695                700
Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
 705                710                715                720
Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala 
                 725                730                735
Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
             740                745                750
Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr 
         755                760                765
Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile 
     770                775                780
Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
 785                790                795                800
Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala 
                 805                810                815
Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp 
             820                825                830
Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly 
         835                840                845
Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala 
     850                855                860
Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp 
 865                870                875                880
Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
                 885                890                895
Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe 
             900                905                910
Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys 
         915                920                925
Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu 
     930                935                940
Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr 
 945                950                955                960
Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser 
                 965                970                975
Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp 
             980                985                990
Glu Ile Arg Lys Leu Ile Leu Arg Arg Asn Pro Gly Gly Trp Val Glu 
         995                1000                1005
Lys Glu Thr Tyr Tyr 
     1010



<210> 3584
<211> 587
<212> DNA
<213> Homo sapiens
<308> M37457
<400> 3584

tctttgtct  tccaggttc  gtggagaag  aaacctact  ctgacctca  ccccaccac  60
tcgcccatc  cttccccgt  cgcaggcca  gaccgcccc  gtcagtccc  ccaattttg  120
attctgggg  gaggagccc  cttcctgtg  ccccacctt  gcccccacc  cctccacta  180
ctcctgccg  ccccactct  gctggcttc  ctcccctgc  ccaaacctc  ctcctctct  240
ttttctgtg  cagtttctc  ccctctcct  acccctcta  ccattcctc  cgccccagc  300
acctccctg  gctcttttt  actcccctt  agccccccg  tgatgccat  tctggttct  360
gacaattat  aaatatatc  gtggggaga  agaagcggt  tgtgtgttg  gcctgcttt  420
cagacgggg  ctgcggctg  gacagcatc  cctctgttg  ggcgcgctg  caggcgact  480
tcgaaactg  aggaactta  cctggcact  gcttggaag  cacggaatc  cagagccat  540
taatcacgg  gttttcaac  ccacgaaag  cagagcagc  tgaattc  587



<210> 3585
<211> 1013
<212> PRT
<213> Homo sapiens
<308> P13637
<400> 3585

Met Gly Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly 
  1               5                  10                  15
Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr 
             20                  25                  30
Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp 
         35                  40                  45
Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg 
     50                  55                  60
Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val 
 65                  70                  75                  80
Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile 
                 85                  90                  95
Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu 
             100                105                110
Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala 
         115                120                125
Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser 
     130                135                140
Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu 
 145                150                155                160
Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val 
                 165                170                175
Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp 
             180                185                190
Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu 
         195                200                205
Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp 
     210                215                220
Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val 
 225                230                235                240
Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val 
                 245                250                255
Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr 
             260                265                270
Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val 
         275                280                285
Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly 
     290                295                300
Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala 
 305                310                315                320
Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Val 
                 325                330                335
Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu 
             340                345                350
Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr 
         355                360                365
Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp 
     370                375                380
Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser 
 385                390                395                400
Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly 
                 405                410                415
Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val 
             420                425                430
Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys 
         435                440                445
Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn 
     450                455                460
Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu 
 465                470                475                480
Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val 
                 485                490                495
Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr Ile Leu 
             500                505                510
Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe 
         515                520                525
Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly 
     530                535                540
Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Tyr Pro Gln Gly Phe Ala 
 545                550                555                560
Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val 
                 565                570                575
Gly Leu Met Ser Met Ile Gly Pro Pro Arg Ala Ala Val Pro Asp Ala 
             580                585                590
Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
         595                600                605
Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
     610                615                620
Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile 
 625                630                635                640
Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His 
                 645                650                655
Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu 
             660                665                670
Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
         675                680                685
Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val 
     690                695                700
Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
 705                710                715                720
Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala 
                 725                730                735
Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
             740                745                750
Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr 
         755                760                765
Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile 
     770                775                780
Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
 785                790                795                800
Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala 
                 805                810                815
Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp 
             820                825                830
Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly 
         835                840                845
Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala 
     850                855                860
Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp 
 865                870                875                880
Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
                 885                890                895
Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe 
             900                905                910
Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys 
         915                920                925
Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu 
     930                935                940
Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr 
 945                950                955                960
Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser 
                 965                970                975
Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp 
             980                985                990
Glu Ile Arg Lys Leu Ile Leu Arg Arg Asn Pro Gly Gly Trp Val Glu 
         995                1000                1005
Lys Glu Thr Tyr Tyr 
     1010



<210> 3586
<211> 2787
<212> DNA
<213> Rattus norvegicus
<308> M28648
<400> 3586

atgaatctt  aaaaagatg  caagagctc  cccaagaag  gcaaggcca  agagcgccg  60
gacctggat  acctcaaga  ggaagtggc  atgacagag  ataaaatgt  agtagaaga  120
gtctgccgg  aatacaata  cgactgcgt  cagggtctg  cacacagta  agcccagga  180
atcctagcc  gggatgggc  taacgccct  acaccaccg  ccaccaccc  agaatgggt  240
aagttctgc  gacagctat  tggtggctt  tccatcctg  tgtggatcg  ggcgatcct  300
tgcttcctg  gctatggca  ccaggcagg  actgaggat  aaccttccg  tgacaatct  360
tacctgggc  tagtgctgg  cggtgtggt  atcatcacc  gctgcttct  ctactacca  420
gaagccaag  gctctaaga  tatgcagtc  ttcacgaac  tggttcccc  gcaagccct  480
gtgatccgg  aaggtgata  gatgcaggt  aatgcggag  aggtggtcg  cggggacct  540
gtggagatc  agggtggcg  tcgggtgcc  gctgagctg  gcatcatct  ggcccatcg  600
tgcaaggtg  acaactctt  cctgactgg  gaatctgag  ctcagaccc  ctccccgga  660
tgcacacac  acaacccat  ggagacccg  aacatcacc  tcttttcca  caactgtgt  720
gaaggcacc  ctcgtggtg  ggtggtagc  acaggtgac  gcaccgtca  gggccgcat  780
gccaccctg  cctcaggcc  ggaggtggg  aagacgccc  tcgccattg  gatcgagca  840
ttcatccag  tcatcactg  cgtggccgt  ttcctgggc  tctccttct  catcctctc  900
ctcattctg  gctacacct  gctggaggc  gtcatcttc  tcatcggta  cattgtggc  960
aatgtccca  agggcctgc  ggctactgt  acggtgtgt  tgacgctga  cgcaaggat  1020
gctcggaag  actgtctgg  aaagaacct  gaggcggtg  agacgctag  ctccacatc  1080
accatctgc  ccgacaaga  cggcaccct  acccagaac  gcatgaccg  cgcccacat  1140
tggtttgac  accagatcc  cgaggccga  actactgag  atcagtcag  gacctcttt  1200
gacaagagc  cacacacct  ggtggccct  tcccacatc  ccggtctct  caaccgggc  1260
gtctttaag  gcgggcagg  taacatccc  gtactcaag  gggacgtgg  gggtgatgc  1320
tcagagtcc  ccctgctta  gtgcatcga  ctgtcctcg  gttccgtaa  gctgatgcg  1380
gaacgaaac  agaaagtcg  cgagattcc  ttcaactcc  ctaacaaat  ccagctatc  1440
atccatgag  ctgaggacc  caatgacaa  cgatacctg  tagtgatga  gggcgcccc  1500
gaacgcatt  tggaccgct  tgcgaccat  ctcctgcag  gcaaggagc  gcctctgga  1560
gaggagatg  aggaggcct  ccagaacgc  tacctggag  ttggtggcc  gggcgagcg  1620
gtgctgggt  tctgccatt  ctacctgcc  gaggaacag  tccccaagg  ctttgcctt  1680
gactgtgat  acgtgaact  caccacaga  aacctttgc  tcgtgggtc  catgtccat  1740
atcgaccct  cccgggcag  tgtccctga  gctgttggc  aatgccgca  tgcaggcat  1800
aaggtcatc  tggtcaccg  cgatcaccc  atcactgcg  aggccatcg  caaaggtaa  1860
ggcatcatc  ccgagggta  cgagactgt  gaggacatc  ctgcccggc  caacatccc  1920
gtcagccag  tcaacccca  ggatgccaa  gcctgtgtg  ttcatggca  tgacctcaa  1980
gacttcacc  ctgagcaga  tgacgagat  ctccagaac  acactgaga  cgtctttgc  2040
cgaacctcc  ctcagcaga  gctcatcat  gtggagggc  gtcagagac  gggagcaat  2100
gtggctgtg  ctggcgatg  tgtgaatga  tcccctgct  tgaagaagg  tgatattgg  2160
gtggccatg  gcattgctg  ctctgatgt  tctaagcag  ctgccgaca  gattctgct  2220
gatgacaat  ttgcttcca  tgtcactgg  gtggaggaa  gccgcctga  ctttgacaa  2280
ctgaagaaa  ccatcgcct  cactctgac  agcaacatc  ctgagatca  acccttcct  2340
ctcttcatc  tggccaaca  cccactgcc  cttggcacc  tcaccatcc  ctgcattga  2400
ctgggcacc  acatggacc  tacaatctc  ttggcctac  aggctgcag  gagtgacat  2460
atgaagagg  agcccagga  cccacgcac  gacaaactg  tcaacgaaa  gctcatcag  2520
atggcctat  ggcagatcg  gatgatcca  gccctcgga  gtttcttct  ctactttgt  2580
atcctggca  aaaatggtt  cttgcccgg  aacctggtg  gcatccggc  caactggga  2640
gaccgcact  tcaacgacc  ggaagacag  tacgggcag  agtggactt  tgagcagag  2700
aaggtggtt  agttcacgt  ccacacagc  ttcttcgtg  gcatagtgg  ggtccagtg  2760
gctgacctg  tcatttgca  gaccagg  2787



<210> 3587
<211> 1013
<212> PRT
<213> Rattus norvegicus
<308> AAA41672
<400> 3587

Met Gly Asp Lys Lys Asp Asp Lys Ser Ser Pro Lys Lys Ser Lys Ala 
  1               5                  10                  15
Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr 
             20                  25                  30
Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp 
         35                  40                  45
Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg 
     50                  55                  60
Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val 
 65                  70                  75                  80
Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile 
                 85                  90                  95
Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu 
             100                105                110
Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala 
         115                120                125
Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser 
     130                135                140
Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu 
 145                150                155                160
Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val 
                 165                170                175
Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp 
             180                185                190
Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu 
         195                200                205
Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp 
     210                215                220
Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val 
 225                230                235                240
Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val 
                 245                250                255
Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr 
             260                265                270
Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val 
         275                280                285
Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly 
     290                295                300
Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala 
 305                310                315                320
Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Leu 
                 325                330                335
Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu 
             340                345                350
Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr 
         355                360                365
Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp 
     370                375                380
Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser 
 385                390                395                400
Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly 
                 405                410                415
Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val 
             420                425                430
Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys 
         435                440                445
Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn 
     450                455                460
Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu 
 465                470                475                480
Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val 
                 485                490                495
Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ala Thr Ile Leu 
             500                505                510
Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe 
         515                520                525
Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly 
     530                535                540
Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala 
 545                550                555                560
Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val 
                 565                570                575
Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
             580                585                590
Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
         595                600                605
Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
     610                615                620
Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile 
 625                630                635                640
Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His 
                 645                650                655
Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu 
             660                665                670
Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
         675                680                685
Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val 
     690                695                700
Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
 705                710                715                720
Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala 
                 725                730                735
Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
             740                745                750
Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr 
         755                760                765
Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile 
     770                775                780
Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
 785                790                795                800
Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala 
                 805                810                815
Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp 
             820                825                830
Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly 
         835                840                845
Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala 
     850                855                860
Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp 
 865                870                875                880
Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
                 885                890                895
Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe 
             900                905                910
Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys 
         915                920                925
Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu 
     930                935                940
Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr 
 945                950                955                960
Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser 
                 965                970                975
Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp 
             980                985                990
Glu Ile Arg Lys Leu Ile Leu Arg Arg Asn Pro Gly Gly Trp Val Glu 
         995                1000                1005
Lys Glu Thr Tyr Tyr 
     1010



<210> 3588
<211> 4346
<212> DNA
<213> Rattus norvegicus
<308> M29249
<400> 3588

ataagcgca  ttccttccg  cctggtctc  nttggctgg  gacggcgga  gggcggctt  60
gtggcctcc  ttgagatcc  gaggatcca  ggactgtgt  gctacaatg  tgtcaagac  120
tttccgtat  catggcctc  ttgtggcct  ccatccctg  gaggtaatt  tgggaacgg  180
gacacttac  atctgtatg  tgtccatga  catgttcac  ggcaacaac  agatctgtg  240
ttggaatta  gagtgccca  aatttgaag  ggacgtgct  agcagcgac  tcatcatcc  300
cacgataac  cggtgcatc  ccatcctgt  catctactt  cagttccag  acctgcgtc  360
gcttgggtc  aagtacatt  tgggtattg  cggcctctt  acaattttc  caagtttcg  420
cttcagcac  gtcgtcatt  atttcctcg  caaagaatt  acaggctta  atgaagctt  480
gcccttttt  ctgctcttg  ttgaccttt  tagagcgag  gcattggcc  agtttgccc  540
gagttcaaa  tcacaggat  aagtaaggg  gaatatagc  cgtgggatg  cgatcctgg  600
ccccacgtt  acccttgac  ctctggtgg  atgtcttgt  attggagtt  gcaccatgt  660
aggggtgcg  cagcttgag  tcatgtgct  ctttggctg  atgtccgtg  ttgccaact  720
ctttgtctt  atgacattc  tcccagcct  cgtgtccct  gtcctagag  tttctcggg  780
aagccgtga  ggtcgtcca  tttggcagc  cagccattt  gccagagtt  tagaagaag  840
agagaataa  ccaaaccca  taacccaaa  ggtcaagat  atcatgtct  taggcctgg  900
tcttgttca  gctcacagt  gctggatag  tgatccttc  cctcagaac  gcacagcag  960
acagtctaa  gtttccttg  gtctggctg  agatgtgtc  aagagaatt  agccgagtg  1020
ttctctctg  cagttttac  tctccaaga  gatcagcat  gacatcgag  aagtgatta  1080
cctgagctt  gcgttgctt  tggctgtca  gtatatttt  tttgaacaa  cagagacag  1140
atcaacact  tcattaaaa  atcctatca  atctcctgt  gtgacccca  agaaagctc  1200
agacaactg  tgtagacgt  agcctctgc  tgtgaggag  aaccagaag  tttcgtcag  1260
ggaggagga  ccaggagtg  accaagaca  aaaagttga  gttataaaa  ctttagtgg  1320
agaagccga  acttcgggc  gagctacgt  tgtgcttgg  gcctctgca  ccagccctc  1380
attggccct  ggggcacag  agcctggga  cgaactccc  agcgagcct  gacctaatg  1440
agagtgtct  cagatactg  agagtgcag  gaaaggtgc  aagttcctt  gtgatgcag  1500
gatcatcca  ttggtcaat  ctaagcaca  cccagccta  aaactggaa  ccctcatgg  1560
gacgcacga  cgtggtgtg  ctattcgcc  gcagctcct  tccgccaag  ttgcagagc  1620
atcttctct  cagtacctg  cttacagag  ctataatta  tccttggtg  tgggagctt  1680
ctgtgagaa  gtgatcgga  atatgccca  ccctgttgg  gtggcagga  ctctgtgcc  1740
ggatggaaa  gagtaccag  tgccaatgg  aacaacaga  ggttgtctt  tggccagca  1800
gaacagagg  tgcagagcg  tcagtcttg  tggaggtgc  agcagccgg  tccttgcag  1860
tgggatgag  cgaggccca  tggtgcgtc  tcctcgtgc  tgtgactca  cagaggtga  1920
gagctggct  gaaacacct  aagggtttg  agtggtaaa  gaggccttc  acagcacga  1980
cagatttgc  cgtctacag  aacttcacg  gacgctggc  ggacgcaac  tctacatcc  2040
tctccagtc  aaaacgggg  acgccatgg  gatgaacat  atttccaag  gtacggaga  2100
agcacttct  aagctgcaa  agggcgtgc  ggagctgca  atactggcg  tcagtggta  2160
ctattgcac  gacaagaaa  ctgctgcca  aaactggat  gaagggaga  gaaagactg  2220
ggtttgtga  gctgtcatt  cagccaagg  ggtgagaga  gtattaaag  cgactacgg  2280
agctatggt  gacgtaaac  ttaacaaga  tcttgtggg  tctgccatg  ctggtagca  2340
aggaggcta  aacctccat  ctgccaaca  cgtcactgc  atctacatt  catgtggcc  2400
ggatgcagc  cagaatgtg  ggagttcaa  ctgtattac  ttaatggaa  caagtggtc  2460
cacaaatga  gacttatac  tcagctgta  catgccgtc  atagagatc  gaaccgtgg  2520
tggtgggac  aaccttcta  ctcagcaag  ctgcctgca  atgctaggt  ttcaagggg  2580
gtgcaaaga  aatcctgga  aaaatgcac  gcagcttgc  cgaattgtg  gtggcactg  2640
gatggctgg  gagttgtcc  tgatggcag  attggcagc  ggacatctt  tcagaagtc  2700
catggttca  aacagatca  agataaatt  acaagatct  caaggaaca  gcaccaaga  2760
ggcagcttg  gcatcctga  atactggac  gaaacacgg  cattgggtt  tccaggact  2820
acatgaaat  tgtgaatta  aaatgtcag  gcagtgtct  gtggaagat  aacgtgatc  2880
gtgaggcag  cacctgctt  gtttctggc  tctttagag  cgtctgcgg  cctttgcac  2940
gactcctca  acgtgggaa  tatggttct  tccgtgccg  gttctagaa  atctcatgt  3000
gatgtcatg  gctctgagc  ccacagatg  gactgcagc  cgtttctga  agctgccac  3060
agctggaag  tggtgtttt  acgaaatga  ggatcctgg  gatcagtgt  gggctcacc  3120
ccaatgggt  aaaatggag  tttaaatga  actgtagct  acagaactt  tgattttta  3180
ttattcagt  tgggttgta  aactttgca  tctaagttt  ttttttgta  actaataat  3240
catttggtg  tggtctatt  atttttggg  acctacttc  tcatggaag  attactttt  3300
ttctcaaac  acagaataa  gtgctaagt  gtgctaaat  gttctcgac  aagaaaaga  3360
tcgctgtgt  catctcagt  tttgttcag  gaggccttt  gctgtgcac  gtctgcact  3420
aagacacag  gctcttagt  ttagagcag  gtacaagca  gtcggacct  tcaggactt  3480
gagtgtggg  gcagttttt  aagaaaaca  ccattgctc  aagccaact  tcttgggag  3540
cattttaac  tatttagct  aattctaga  ttcttggta  actatcaaa  ctgtatatg  3600
tgtaataaa  tgtctaatg  taggagttt  ttggaagtg  ttaagaaat  aaagtactc  3660
tcagctttt  cacggataa  atgctctag  ttgggccag  gaagacctc  ctcaggagc  3720
ttggtccgg  aaagcctgg  ttgcttgcc  agcctaatg  agggaagtc  gcctacaga  3780
ccagtgatg  agccacatg  atggccctg  agctgtgtg  cttgttcct  tggccagga  3840
ttaggtgac  gaatcattt  tgggctcct  tggtggacc  cataaaagc  cttagcttc  3900
ctcaggggg  gtcagcaga  ttgttgaat  ttaattttt  ttttaatgt  ccagtttgt  3960
ataaataat  ataaagagc  ccttatttt  tattctatc  aatgcttcg  ttggtcttg  4020
aagcggacg  ctgtgtaga  gacggactc  gaaagtgag  atcgatgac  cgcgcgcgc  4080
cgactgacg  tagtgatgg  tagatatgt  gaaggtagc  tcgtgtgta  gtaaagttt  4140
cagttgcgc  tcttgtgac  tttcagcca  taccatttt  tttacctga  cttgtcgtg  4200
gaagtggta  taaaccgca  tgagtgttg  tgctggtga  ttgtgatca  tgtcatcgt  4260
ctaagtcca  gttttgtac  attactaaa  tgtatacat  ttgttatag  atacttttt  4320
cagttgagt  attatgaaa  gaagtt  4346



<210> 3589
<211> 887
<212> PRT
<213> Rattus norvegicus
<308> P51639
<400> 3589

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
  1               5                  10                  15
Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
             20                  25                  30
Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
         35                  40                  45
Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
     50                  55                  60
Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
 65                  70                  75                  80
Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                 85                  90                  95
Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
             100                105                110
Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
         115                120                125
Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Ala Leu Ala Lys Phe Ala 
     130                135                140
Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
 145                150                155                160
Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                 165                170                175
Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
             180                185                190
Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
         195                200                205
Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
     210                215                220
Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
 225                230                235                240
Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                 245                250                255
Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
             260                265                270
Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Glu Gln Ser Lys 
         275                280                285
Val Ser Leu Gly Leu Ala Glu Asp Val Ser Lys Arg Ile Glu Pro Ser 
     290                295                300
Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
 305                310                315                320
Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                 325                330                335
Ile Phe Phe Glu Gln Ala Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
             340                345                350
Pro Ile Thr Ser Pro Val Val Thr Pro Lys Lys Ala Gln Asp Asn Cys 
         355                360                365
Cys Arg Arg Glu Pro Leu Leu Val Arg Arg Asn Gln Lys Leu Ser Ser 
     370                375                380
Val Glu Glu Asp Pro Gly Val Asn Gln Asp Arg Lys Val Glu Val Ile 
 385                390                395                400
Lys Pro Leu Val Ala Glu Ala Glu Thr Ser Gly Arg Ala Thr Phe Val 
                 405                410                415
Leu Gly Ala Ser Ala Ala Ser Pro Pro Leu Ala Leu Gly Ala Gln Glu 
             420                425                430
Pro Gly Ile Glu Leu Pro Ser Glu Pro Arg Pro Asn Glu Glu Cys Leu 
         435                440                445
Gln Ile Leu Glu Ser Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp Ala 
     450                455                460
Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys Leu 
 465                470                475                480
Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg Gln 
                 485                490                495
Leu Leu Ser Ala Lys Leu Ala Glu Pro Ser Ser Leu Gln Tyr Leu Pro 
             500                505                510
Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu Asn 
         515                520                525
Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu Cys 
     530                535                540
Leu Asp Gly Lys Glu Tyr Gln Val Pro Met Ala Thr Thr Glu Gly Cys 
 545                550                555                560
Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Ser Leu Gly Gly 
                 565                570                575
Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Ser Arg Gly Pro Val 
             580                585                590
Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ser Trp Leu 
         595                600                605
Glu Thr Pro Glu Gly Phe Ala Val Val Lys Glu Ala Phe Asp Ser Thr 
     610                615                620
Ser Arg Phe Ala Arg Leu Gln Lys Leu His Val Thr Leu Ala Gly Arg 
 625                630                635                640
Asn Leu Tyr Ile Arg Leu Gln Ser Lys Thr Gly Asp Ala Met Gly Met 
                 645                650                655
Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Leu Lys Leu Gln Glu 
             660                665                670
Gly Val Pro Glu Leu Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys Thr 
         675                680                685
Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Thr 
     690                695                700
Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val Leu 
 705                710                715                720
Lys Thr Thr Thr Glu Ala Met Val Asp Val Asn Ile Asn Lys Asn Leu 
                 725                730                735
Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Leu His Ala 
             740                745                750
Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala Ala 
         755                760                765
Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser Gly 
     770                775                780
Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile Glu 
 785                790                795                800
Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala Cys 
                 805                810                815
Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly Glu 
             820                825                830
Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala Gly 
         835                840                845
Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Arg Ser 
     850                855                860
His Met Val His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln Gly 
 865                870                875                880
Thr Cys Thr Lys Lys Ala Ala 
                 885



<210> 3590
<211> 2904
<212> DNA
<213> Homo sapiens
<308> M11058
<400> 3590

ttcggtggc  tctagtgag  tctggagga  ccaaggatt  tgtagctac  atgttgtca  60
gactttttc  aatgcatgg  ctctttgtg  cctcccatc  ctgggaagt  atagtgggg  120
cagtgacac  gaccatctg  atgatgtcc  tgaacatgt  tactggtaa  aataagatc  180
gtggttgga  ttatgaatg  ccaaagttt  aagaggatg  tttgagcag  gacattata  240
ttctgacaa  aacacgatg  atagccatc  tgtatattt  cttccagtt  cagaattta  300
gtcaacttg  atcaaaata  attttgggt  ttgctggcc  tttcacaat  ttctcaagt  360
ttgtattca  tacagttgt  attcacttc  tagacaaag  attgacagg  ttgaatgaa  420
ctttgccct  tttcctact  ttgattgac  tttccagag  aagcacatt  gcaaagttt  480
ccctcagtt  caactcaca  gatgaagta  gggaaaata  tgctcgtgg  atggcaatt  540
taggtccta  gtttaccct  gatgctctt  ttgaatgtc  tgtgattgg  gttggtacc  600
tgtcagggg  acgtcagct  gaaattatg  gctgctttg  ctgcatgtc  gttcttgcc  660
actacttcg  gttcatgac  ttcttccca  cttgtgtgt  cttggtatt  gagctttct  720
gggaaagcc  cgagggtcg  ccaatttgg  agctcagcc  ttttgcccg  gttttagaa  780
aagaagaaa  taagccgaa  cctgtaact  agagggtca  gatgattat  tctctaggc  840
tggttcttg  tcatgctca  agtcgctgg  tagctgatc  ttctcctca  aacagtaca  900
cagatactt  taaggtttc  ttaggactg  atgaaaatg  gtccaagag  attgaacca  960
gtgtttccc  ctggcagtt  tatctctct  aaatgatca  catggatat  gaacaagtt  1020
ttaccctaa  tttagctct  cttctggct  tcaagtaca  cttctttga  caaacagag  1080
cagaatcta  actctcatt  aaaaaccct  tcacatctc  tgtagtgac  caaaagaaa  1140
tcccagaca  ttgttgtag  cgtgaacct  tgctggtca  aaataacca  aaatgtgat  1200
cagtagagg  agagacagg  ataaaccga  aaagaaaag  tgaggttat  aaaccctta  1260
tggctgaaa  agatacccc  aacagagct  catttgtgg  tggtaactc  tccttactc  1320
atacttcat  agtactggt  acacaggaa  ctgaaattg  acttcccag  gaacctcgg  1380
ctaatgaag  atgtctaca  atacttggg  atgcagaga  aggtgcaaa  ttccttagt  1440
atgctgaga  catccagtt  gtcaatgct  agcatatcc  agcctacaa  ttggaaact  1500
tgatggaaa  tcatgagcg  ggtgtatct  ttcgccgac  gttactttc  aagaagctt  1560
cagaacctt  ttctctcca  tacctacct  acagggatt  taattactc  ttggtgatg  1620
gagcttgtt  tgagaatgt  attggatat  tgcccatcc  tgttggagt  gcaggaccc  1680
tttgcttag  tgaaaaaga  tttcaggtt  caatggcaa  aacagaagg  tgtcttgtg  1740
ccagcacca  tagaggctg  agagcaata  gtcttggtg  aggtgccag  agccgagtc  1800
ttgcagatg  gatgactcg  ggcccagtt  tgcgtcttc  acgtgcttg  gactctgca  1860
aagtgaaag  ctggctcga  acatctgaa  ggttcgcag  gataaagga  gcatttgac  1920
gcactagca  atttgcacg  ctacagaaa  ttcatacaa  tatagctgg  cgcaacctt  1980
atatccgtt  ccagtccag  tcaggggat  ccatgggga  gaacatgat  tcaaagggt  2040
cagagaaag  actttcaaa  cttcacgag  atttccctg  aatgcagat  ctagccgtt  2100
gtggtaact  ttgtactga  aagaaacct  ctgctataa  ttggataga  ggaagagga  2160
aatctgttg  ttgtgaagc  gtcattcca  ccaaggttg  cagagaagt  ttaaagact  2220
ccacagagg  tatgattga  gtcaacatt  acaagaatt  agtgggctc  gccatggct  2280
ggagcatag  aggctacaa  gcccatgca  caaacattg  caccgccat  tacattgcc  2340
gtggacagg  tgcagcaca  aatgttggt  gttcaaact  tattacttt  atggaagca  2400
gtggtccca  aaatgaaga  ttatatatc  gctgcacca  gccatctat  gagatagga  2460
cggtgggtg  tgggaccaa  ctactacct  agcaagcct  tttgcagat  ctaggtgtt  2520
aaggagcat  caaagataa  cctggggaa  atgcccggc  gcttgcccg  attgtgtgt  2580
ggaccgtaa  ggctgggga  ttgtcactt  tggcagcat  ggcagcagg  catcttgtc  2640
aaagtcaca  gattcacaa  aggtcgaag  tcaatttac  agacctcca  ggagcttgc  2700
ccaagaaga  agcctgaat  gcccgacag  tctgaactg  aacatgggc  ttgggttct  2760
aaggactaa  ataaaatct  tgaattaaa  aagctcaat  cattgtctt  tggaggatg  2820
ataaatgtg  tcactgaga  agccacttg  tttttggct  tttcagaga  gtctcaggt  2880
ctttccatg  agactcctc  gatc  2904



<210> 3591
<211> 888
<212> PRT
<213> Homo sapiens
<308> P04035
<400> 3591

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
  1               5                  10                  15
Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
             20                  25                  30
Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
         35                  40                  45
Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
     50                  55                  60
Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
 65                  70                  75                  80
Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                 85                  90                  95
Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
             100                105                110
Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
         115                120                125
Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Thr Leu Ala Lys Phe Ala 
     130                135                140
Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
 145                150                155                160
Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                 165                170                175
Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
             180                185                190
Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
         195                200                205
Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
     210                215                220
Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
 225                230                235                240
Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                 245                250                255
Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
             260                265                270
Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Asp Thr Ser Lys 
         275                280                285
Val Ser Leu Gly Leu Asp Glu Asn Val Ser Lys Arg Ile Glu Pro Ser 
     290                295                300
Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
 305                310                315                320
Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                 325                330                335
Ile Phe Phe Glu Gln Thr Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
             340                345                350
Pro Ile Thr Ser Pro Val Val Thr Gln Lys Lys Val Pro Asp Asn Cys 
         355                360                365
Cys Arg Arg Glu Pro Met Leu Val Arg Asn Asn Gln Lys Cys Asp Ser 
     370                375                380
Val Glu Glu Glu Thr Gly Ile Asn Arg Glu Arg Lys Val Glu Val Ile 
 385                390                395                400
Lys Pro Leu Val Ala Glu Thr Asp Thr Pro Asn Arg Ala Thr Phe Val 
                 405                410                415
Val Gly Asn Ser Ser Leu Leu Asp Thr Ser Ser Val Leu Val Thr Gln 
             420                425                430
Glu Pro Glu Ile Glu Leu Pro Arg Glu Pro Arg Pro Asn Glu Glu Cys 
         435                440                445
Leu Gln Ile Leu Gly Asn Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp 
     450                455                460
Ala Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys 
 465                470                475                480
Leu Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg 
                 485                490                495
Gln Leu Leu Ser Lys Lys Leu Ser Glu Pro Ser Ser Leu Gln Tyr Leu 
             500                505                510
Pro Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu 
         515                520                525
Asn Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu 
     530                535                540
Cys Leu Asp Glu Lys Glu Phe Gln Val Pro Met Ala Thr Thr Glu Gly 
 545                550                555                560
Cys Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Gly Leu Gly 
                 565                570                575
Gly Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Thr Arg Gly Pro 
             580                585                590
Val Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ala Trp 
         595                600                605
Leu Glu Thr Ser Glu Gly Phe Ala Val Ile Lys Glu Ala Phe Asp Ser 
     610                615                620
Thr Ser Arg Phe Ala Arg Leu Gln Lys Leu His Thr Ser Ile Ala Gly 
 625                630                635                640
Arg Asn Leu Tyr Ile Arg Phe Gln Ser Arg Ser Gly Asp Ala Met Gly 
                 645                650                655
Met Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Ser Lys Leu His 
             660                665                670
Glu Tyr Phe Pro Glu Met Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys 
         675                680                685
Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys 
     690                695                700
Ser Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val 
 705                710                715                720
Leu Lys Thr Thr Thr Glu Ala Met Ile Glu Val Asn Ile Asn Lys Asn 
                 725                730                735
Leu Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Ala His 
             740                745                750
Ala Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala 
         755                760                765
Ala Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser 
     770                775                780
Gly Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile 
 785                790                795                800
Glu Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala 
                 805                810                815
Cys Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly 
             820                825                830
Glu Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala 
         835                840                845
Gly Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Lys 
     850                855                860
Ser His Met Ile His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln 
 865                870                875                880
Gly Ala Cys Thr Lys Lys Thr Ala 
                 885



<210> 3592
<211> 4346
<212> DNA
<213> Rattus norvegicus
<308> M29249
<400> 3592

ataagcgca  ttccttccg  cctggtctc  nttggctgg  gacggcgga  gggcggctt  60
gtggcctcc  ttgagatcc  gaggatcca  ggactgtgt  gctacaatg  tgtcaagac  120
tttccgtat  catggcctc  ttgtggcct  ccatccctg  gaggtaatt  tgggaacgg  180
gacacttac  atctgtatg  tgtccatga  catgttcac  ggcaacaac  agatctgtg  240
ttggaatta  gagtgccca  aatttgaag  ggacgtgct  agcagcgac  tcatcatcc  300
cacgataac  cggtgcatc  ccatcctgt  catctactt  cagttccag  acctgcgtc  360
gcttgggtc  aagtacatt  tgggtattg  cggcctctt  acaattttc  caagtttcg  420
cttcagcac  gtcgtcatt  atttcctcg  caaagaatt  acaggctta  atgaagctt  480
gcccttttt  ctgctcttg  ttgaccttt  tagagcgag  gcattggcc  agtttgccc  540
gagttcaaa  tcacaggat  aagtaaggg  gaatatagc  cgtgggatg  cgatcctgg  600
ccccacgtt  acccttgac  ctctggtgg  atgtcttgt  attggagtt  gcaccatgt  660
aggggtgcg  cagcttgag  tcatgtgct  ctttggctg  atgtccgtg  ttgccaact  720
ctttgtctt  atgacattc  tcccagcct  cgtgtccct  gtcctagag  tttctcggg  780
aagccgtga  ggtcgtcca  tttggcagc  cagccattt  gccagagtt  tagaagaag  840
agagaataa  ccaaaccca  taacccaaa  ggtcaagat  atcatgtct  taggcctgg  900
tcttgttca  gctcacagt  gctggatag  tgatccttc  cctcagaac  gcacagcag  960
acagtctaa  gtttccttg  gtctggctg  agatgtgtc  aagagaatt  agccgagtg  1020
ttctctctg  cagttttac  tctccaaga  gatcagcat  gacatcgag  aagtgatta  1080
cctgagctt  gcgttgctt  tggctgtca  gtatatttt  tttgaacaa  cagagacag  1140
atcaacact  tcattaaaa  atcctatca  atctcctgt  gtgacccca  agaaagctc  1200
agacaactg  tgtagacgt  agcctctgc  tgtgaggag  aaccagaag  tttcgtcag  1260
ggaggagga  ccaggagtg  accaagaca  aaaagttga  gttataaaa  ctttagtgg  1320
agaagccga  acttcgggc  gagctacgt  tgtgcttgg  gcctctgca  ccagccctc  1380
attggccct  ggggcacag  agcctggga  cgaactccc  agcgagcct  gacctaatg  1440
agagtgtct  cagatactg  agagtgcag  gaaaggtgc  aagttcctt  gtgatgcag  1500
gatcatcca  ttggtcaat  ctaagcaca  cccagccta  aaactggaa  ccctcatgg  1560
gacgcacga  cgtggtgtg  ctattcgcc  gcagctcct  tccgccaag  ttgcagagc  1620
atcttctct  cagtacctg  cttacagag  ctataatta  tccttggtg  tgggagctt  1680
ctgtgagaa  gtgatcgga  atatgccca  ccctgttgg  gtggcagga  ctctgtgcc  1740
ggatggaaa  gagtaccag  tgccaatgg  aacaacaga  ggttgtctt  tggccagca  1800
gaacagagg  tgcagagcg  tcagtcttg  tggaggtgc  agcagccgg  tccttgcag  1860
tgggatgag  cgaggccca  tggtgcgtc  tcctcgtgc  tgtgactca  cagaggtga  1920
gagctggct  gaaacacct  aagggtttg  agtggtaaa  gaggccttc  acagcacga  1980
cagatttgc  cgtctacag  aacttcacg  gacgctggc  ggacgcaac  tctacatcc  2040
tctccagtc  aaaacgggg  acgccatgg  gatgaacat  atttccaag  gtacggaga  2100
agcacttct  aagctgcaa  agggcgtgc  ggagctgca  atactggcg  tcagtggta  2160
ctattgcac  gacaagaaa  ctgctgcca  aaactggat  gaagggaga  gaaagactg  2220
ggtttgtga  gctgtcatt  cagccaagg  ggtgagaga  gtattaaag  cgactacgg  2280
agctatggt  gacgtaaac  ttaacaaga  tcttgtggg  tctgccatg  ctggtagca  2340
aggaggcta  aacctccat  ctgccaaca  cgtcactgc  atctacatt  catgtggcc  2400
ggatgcagc  cagaatgtg  ggagttcaa  ctgtattac  ttaatggaa  caagtggtc  2460
cacaaatga  gacttatac  tcagctgta  catgccgtc  atagagatc  gaaccgtgg  2520
tggtgggac  aaccttcta  ctcagcaag  ctgcctgca  atgctaggt  ttcaagggg  2580
gtgcaaaga  aatcctgga  aaaatgcac  gcagcttgc  cgaattgtg  gtggcactg  2640
gatggctgg  gagttgtcc  tgatggcag  attggcagc  ggacatctt  tcagaagtc  2700
catggttca  aacagatca  agataaatt  acaagatct  caaggaaca  gcaccaaga  2760
ggcagcttg  gcatcctga  atactggac  gaaacacgg  cattgggtt  tccaggact  2820
acatgaaat  tgtgaatta  aaatgtcag  gcagtgtct  gtggaagat  aacgtgatc  2880
gtgaggcag  cacctgctt  gtttctggc  tctttagag  cgtctgcgg  cctttgcac  2940
gactcctca  acgtgggaa  tatggttct  tccgtgccg  gttctagaa  atctcatgt  3000
gatgtcatg  gctctgagc  ccacagatg  gactgcagc  cgtttctga  agctgccac  3060
agctggaag  tggtgtttt  acgaaatga  ggatcctgg  gatcagtgt  gggctcacc  3120
ccaatgggt  aaaatggag  tttaaatga  actgtagct  acagaactt  tgattttta  3180
ttattcagt  tgggttgta  aactttgca  tctaagttt  ttttttgta  actaataat  3240
catttggtg  tggtctatt  atttttggg  acctacttc  tcatggaag  attactttt  3300
ttctcaaac  acagaataa  gtgctaagt  gtgctaaat  gttctcgac  aagaaaaga  3360
tcgctgtgt  catctcagt  tttgttcag  gaggccttt  gctgtgcac  gtctgcact  3420
aagacacag  gctcttagt  ttagagcag  gtacaagca  gtcggacct  tcaggactt  3480
gagtgtggg  gcagttttt  aagaaaaca  ccattgctc  aagccaact  tcttgggag  3540
cattttaac  tatttagct  aattctaga  ttcttggta  actatcaaa  ctgtatatg  3600
tgtaataaa  tgtctaatg  taggagttt  ttggaagtg  ttaagaaat  aaagtactc  3660
tcagctttt  cacggataa  atgctctag  ttgggccag  gaagacctc  ctcaggagc  3720
ttggtccgg  aaagcctgg  ttgcttgcc  agcctaatg  agggaagtc  gcctacaga  3780
ccagtgatg  agccacatg  atggccctg  agctgtgtg  cttgttcct  tggccagga  3840
ttaggtgac  gaatcattt  tgggctcct  tggtggacc  cataaaagc  cttagcttc  3900
ctcaggggg  gtcagcaga  ttgttgaat  ttaattttt  ttttaatgt  ccagtttgt  3960
ataaataat  ataaagagc  ccttatttt  tattctatc  aatgcttcg  ttggtcttg  4020
aagcggacg  ctgtgtaga  gacggactc  gaaagtgag  atcgatgac  cgcgcgcgc  4080
cgactgacg  tagtgatgg  tagatatgt  gaaggtagc  tcgtgtgta  gtaaagttt  4140
cagttgcgc  tcttgtgac  tttcagcca  taccatttt  tttacctga  cttgtcgtg  4200
gaagtggta  taaaccgca  tgagtgttg  tgctggtga  ttgtgatca  tgtcatcgt  4260
ctaagtcca  gttttgtac  attactaaa  tgtatacat  ttgttatag  atacttttt  4320
cagttgagt  attatgaaa  gaagtt  4346



<210> 3593
<211> 887
<212> PRT
<213> Rattus norvegicus
<308> P51639
<400> 3593

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
  1               5                  10                  15
Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
             20                  25                  30
Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
         35                  40                  45
Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
     50                  55                  60
Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
 65                  70                  75                  80
Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                 85                  90                  95
Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
             100                105                110
Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
         115                120                125
Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Ala Leu Ala Lys Phe Ala 
     130                135                140
Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
 145                150                155                160
Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                 165                170                175
Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
             180                185                190
Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
         195                200                205
Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
     210                215                220
Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
 225                230                235                240
Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                 245                250                255
Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
             260                265                270
Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Glu Gln Ser Lys 
         275                280                285
Val Ser Leu Gly Leu Ala Glu Asp Val Ser Lys Arg Ile Glu Pro Ser 
     290                295                300
Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
 305                310                315                320
Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                 325                330                335
Ile Phe Phe Glu Gln Ala Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
             340                345                350
Pro Ile Thr Ser Pro Val Val Thr Pro Lys Lys Ala Gln Asp Asn Cys 
         355                360                365
Cys Arg Arg Glu Pro Leu Leu Val Arg Arg Asn Gln Lys Leu Ser Ser 
     370                375                380
Val Glu Glu Asp Pro Gly Val Asn Gln Asp Arg Lys Val Glu Val Ile 
 385                390                395                400
Lys Pro Leu Val Ala Glu Ala Glu Thr Ser Gly Arg Ala Thr Phe Val 
                 405                410                415
Leu Gly Ala Ser Ala Ala Ser Pro Pro Leu Ala Leu Gly Ala Gln Glu 
             420                425                430
Pro Gly Ile Glu Leu Pro Ser Glu Pro Arg Pro Asn Glu Glu Cys Leu 
         435                440                445
Gln Ile Leu Glu Ser Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp Ala 
     450                455                460
Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys Leu 
 465                470                475                480
Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg Gln 
                 485                490                495
Leu Leu Ser Ala Lys Leu Ala Glu Pro Ser Ser Leu Gln Tyr Leu Pro 
             500                505                510
Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu Asn 
         515                520                525
Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu Cys 
     530                535                540
Leu Asp Gly Lys Glu Tyr Gln Val Pro Met Ala Thr Thr Glu Gly Cys 
 545                550                555                560
Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Ser Leu Gly Gly 
                 565                570                575
Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Ser Arg Gly Pro Val 
             580                585                590
Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ser Trp Leu 
         595                600                605
Glu Thr Pro Glu Gly Phe Ala Val Val Lys Glu Ala Phe Asp Ser Thr 
     610                615                620
Ser Arg Phe Ala Arg Leu Gln Lys Leu His Val Thr Leu Ala Gly Arg 
 625                630                635                640
Asn Leu Tyr Ile Arg Leu Gln Ser Lys Thr Gly Asp Ala Met Gly Met 
                 645                650                655
Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Leu Lys Leu Gln Glu 
             660                665                670
Gly Val Pro Glu Leu Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys Thr 
         675                680                685
Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Thr 
     690                695                700
Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val Leu 
 705                710                715                720
Lys Thr Thr Thr Glu Ala Met Val Asp Val Asn Ile Asn Lys Asn Leu 
                 725                730                735
Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Leu His Ala 
             740                745                750
Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala Ala 
         755                760                765
Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser Gly 
     770                775                780
Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile Glu 
 785                790                795                800
Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala Cys 
                 805                810                815
Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly Glu 
             820                825                830
Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala Gly 
         835                840                845
Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Arg Ser 
     850                855                860
His Met Val His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln Gly 
 865                870                875                880
Thr Cys Thr Lys Lys Ala Ala 
                 885



<210> 3594
<211> 2904
<212> DNA
<213> Homo sapiens
<308> M11058
<400> 3594

ttcggtggc  tctagtgag  tctggagga  ccaaggatt  tgtagctac  atgttgtca  60
gactttttc  aatgcatgg  ctctttgtg  cctcccatc  ctgggaagt  atagtgggg  120
cagtgacac  gaccatctg  atgatgtcc  tgaacatgt  tactggtaa  aataagatc  180
gtggttgga  ttatgaatg  ccaaagttt  aagaggatg  tttgagcag  gacattata  240
ttctgacaa  aacacgatg  atagccatc  tgtatattt  cttccagtt  cagaattta  300
gtcaacttg  atcaaaata  attttgggt  ttgctggcc  tttcacaat  ttctcaagt  360
ttgtattca  tacagttgt  attcacttc  tagacaaag  attgacagg  ttgaatgaa  420
ctttgccct  tttcctact  ttgattgac  tttccagag  aagcacatt  gcaaagttt  480
ccctcagtt  caactcaca  gatgaagta  gggaaaata  tgctcgtgg  atggcaatt  540
taggtccta  gtttaccct  gatgctctt  ttgaatgtc  tgtgattgg  gttggtacc  600
tgtcagggg  acgtcagct  gaaattatg  gctgctttg  ctgcatgtc  gttcttgcc  660
actacttcg  gttcatgac  ttcttccca  cttgtgtgt  cttggtatt  gagctttct  720
gggaaagcc  cgagggtcg  ccaatttgg  agctcagcc  ttttgcccg  gttttagaa  780
aagaagaaa  taagccgaa  cctgtaact  agagggtca  gatgattat  tctctaggc  840
tggttcttg  tcatgctca  agtcgctgg  tagctgatc  ttctcctca  aacagtaca  900
cagatactt  taaggtttc  ttaggactg  atgaaaatg  gtccaagag  attgaacca  960
gtgtttccc  ctggcagtt  tatctctct  aaatgatca  catggatat  gaacaagtt  1020
ttaccctaa  tttagctct  cttctggct  tcaagtaca  cttctttga  caaacagag  1080
cagaatcta  actctcatt  aaaaaccct  tcacatctc  tgtagtgac  caaaagaaa  1140
tcccagaca  ttgttgtag  cgtgaacct  tgctggtca  aaataacca  aaatgtgat  1200
cagtagagg  agagacagg  ataaaccga  aaagaaaag  tgaggttat  aaaccctta  1260
tggctgaaa  agatacccc  aacagagct  catttgtgg  tggtaactc  tccttactc  1320
atacttcat  agtactggt  acacaggaa  ctgaaattg  acttcccag  gaacctcgg  1380
ctaatgaag  atgtctaca  atacttggg  atgcagaga  aggtgcaaa  ttccttagt  1440
atgctgaga  catccagtt  gtcaatgct  agcatatcc  agcctacaa  ttggaaact  1500
tgatggaaa  tcatgagcg  ggtgtatct  ttcgccgac  gttactttc  aagaagctt  1560
cagaacctt  ttctctcca  tacctacct  acagggatt  taattactc  ttggtgatg  1620
gagcttgtt  tgagaatgt  attggatat  tgcccatcc  tgttggagt  gcaggaccc  1680
tttgcttag  tgaaaaaga  tttcaggtt  caatggcaa  aacagaagg  tgtcttgtg  1740
ccagcacca  tagaggctg  agagcaata  gtcttggtg  aggtgccag  agccgagtc  1800
ttgcagatg  gatgactcg  ggcccagtt  tgcgtcttc  acgtgcttg  gactctgca  1860
aagtgaaag  ctggctcga  acatctgaa  ggttcgcag  gataaagga  gcatttgac  1920
gcactagca  atttgcacg  ctacagaaa  ttcatacaa  tatagctgg  cgcaacctt  1980
atatccgtt  ccagtccag  tcaggggat  ccatgggga  gaacatgat  tcaaagggt  2040
cagagaaag  actttcaaa  cttcacgag  atttccctg  aatgcagat  ctagccgtt  2100
gtggtaact  ttgtactga  aagaaacct  ctgctataa  ttggataga  ggaagagga  2160
aatctgttg  ttgtgaagc  gtcattcca  ccaaggttg  cagagaagt  ttaaagact  2220
ccacagagg  tatgattga  gtcaacatt  acaagaatt  agtgggctc  gccatggct  2280
ggagcatag  aggctacaa  gcccatgca  caaacattg  caccgccat  tacattgcc  2340
gtggacagg  tgcagcaca  aatgttggt  gttcaaact  tattacttt  atggaagca  2400
gtggtccca  aaatgaaga  ttatatatc  gctgcacca  gccatctat  gagatagga  2460
cggtgggtg  tgggaccaa  ctactacct  agcaagcct  tttgcagat  ctaggtgtt  2520
aaggagcat  caaagataa  cctggggaa  atgcccggc  gcttgcccg  attgtgtgt  2580
ggaccgtaa  ggctgggga  ttgtcactt  tggcagcat  ggcagcagg  catcttgtc  2640
aaagtcaca  gattcacaa  aggtcgaag  tcaatttac  agacctcca  ggagcttgc  2700
ccaagaaga  agcctgaat  gcccgacag  tctgaactg  aacatgggc  ttgggttct  2760
aaggactaa  ataaaatct  tgaattaaa  aagctcaat  cattgtctt  tggaggatg  2820
ataaatgtg  tcactgaga  agccacttg  tttttggct  tttcagaga  gtctcaggt  2880
ctttccatg  agactcctc  gatc  2904



<210> 3595
<211> 888
<212> PRT
<213> Homo sapiens
<308> P04035
<400> 3595

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
  1               5                  10                  15
Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
             20                  25                  30
Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
         35                  40                  45
Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
     50                  55                  60
Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
 65                  70                  75                  80
Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                 85                  90                  95
Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
             100                105                110
Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
         115                120                125
Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Thr Leu Ala Lys Phe Ala 
     130                135                140
Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
 145                150                155                160
Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                 165                170                175
Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
             180                185                190
Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
         195                200                205
Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
     210                215                220
Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
 225                230                235                240
Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                 245                250                255
Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
             260                265                270
Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Asp Thr Ser Lys 
         275                280                285
Val Ser Leu Gly Leu Asp Glu Asn Val Ser Lys Arg Ile Glu Pro Ser 
     290                295                300
Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
 305                310                315                320
Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                 325                330                335
Ile Phe Phe Glu Gln Thr Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
             340                345                350
Pro Ile Thr Ser Pro Val Val Thr Gln Lys Lys Val Pro Asp Asn Cys 
         355                360                365
Cys Arg Arg Glu Pro Met Leu Val Arg Asn Asn Gln Lys Cys Asp Ser 
     370                375                380
Val Glu Glu Glu Thr Gly Ile Asn Arg Glu Arg Lys Val Glu Val Ile 
 385                390                395                400
Lys Pro Leu Val Ala Glu Thr Asp Thr Pro Asn Arg Ala Thr Phe Val 
                 405                410                415
Val Gly Asn Ser Ser Leu Leu Asp Thr Ser Ser Val Leu Val Thr Gln 
             420                425                430
Glu Pro Glu Ile Glu Leu Pro Arg Glu Pro Arg Pro Asn Glu Glu Cys 
         435                440                445
Leu Gln Ile Leu Gly Asn Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp 
     450                455                460
Ala Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys 
 465                470                475                480
Leu Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg 
                 485                490                495
Gln Leu Leu Ser Lys Lys Leu Ser Glu Pro Ser Ser Leu Gln Tyr Leu 
             500                505                510
Pro Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu 
         515                520                525
Asn Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu 
     530                535                540
Cys Leu Asp Glu Lys Glu Phe Gln Val Pro Met Ala Thr Thr Glu Gly 
 545                550                555                560
Cys Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Gly Leu Gly 
                 565                570                575
Gly Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Thr Arg Gly Pro 
             580                585                590
Val Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ala Trp 
         595                600                605
Leu Glu Thr Ser Glu Gly Phe Ala Val Ile Lys Glu Ala Phe Asp Ser 
     610                615                620
Thr Ser Arg Phe Ala Arg Leu Gln Lys Leu His Thr Ser Ile Ala Gly 
 625                630                635                640
Arg Asn Leu Tyr Ile Arg Phe Gln Ser Arg Ser Gly Asp Ala Met Gly 
                 645                650                655
Met Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Ser Lys Leu His 
             660                665                670
Glu Tyr Phe Pro Glu Met Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys 
         675                680                685
Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys 
     690                695                700
Ser Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val 
 705                710                715                720
Leu Lys Thr Thr Thr Glu Ala Met Ile Glu Val Asn Ile Asn Lys Asn 
                 725                730                735
Leu Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Ala His 
             740                745                750
Ala Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala 
         755                760                765
Ala Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser 
     770                775                780
Gly Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile 
 785                790                795                800
Glu Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala 
                 805                810                815
Cys Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly 
             820                825                830
Glu Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala 
         835                840                845
Gly Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Lys 
     850                855                860
Ser His Met Ile His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln 
 865                870                875                880
Gly Ala Cys Thr Lys Lys Thr Ala 
                 885



<210> 3596
<211> 1428
<212> DNA
<213> Rattus norvegicus
<308> M29293
<400> 3596

ccgtctgac  gactccttg  gtatattag  gcggcatct  cgtgtaaca  gttgccttt  60
ttatggtgg  ctgaggttg  tgattgtga  atccaggat  taggagcta  gttgccgca  120
cctctgggc  ccgggatcc  agagctctt  tgtatcggc  ggtggaatc  ttggatgtt  180
gagctgtat  gccgcgacc  gtagattca  ggatcgttt  cacttgaga  gaactactg  240
acagcacgt  ccagagatt  aggtccagg  caaacgtag  aggacagcc  cactgagca  300
ccaagagtg  cacttgtac  cacggcgtt  tcagcaaca  caaattcct  tggtggatt  360
ccaggcaga  ctgagacag  cgttcttag  tgagacacc  agaggtggt  aaagcagta  420
tggaacttc  aggtggtgg  agtcaacaa  cacaggacc  atccactga  tgtgaaact  480
tggtcaagc  tacactgtg  taatagcct  catcaaacc  ttatttatt  cccttctcc  540
agtattaag  atcttgaaa  tttagtgtt  acaactgct  ttgtggaac  gcaatcatg  600
ctgtgggta  gagtagcaa  atgctccag  atattgact  tagaatgag  tgtatcctg  660
aagatggaa  aatcttcat  ggcaccttt  aggcttttg  caagcatat  aatttgatc  720
tctgtgatt  tgatgagtt  aggaagatc  agccaaaga  tgcaaaaca  ccagaacgt  780
aagaaaaac  ggttttggg  ctggtcttg  tacgtggag  gaacttggt  tccatgaca  840
tggagggtc  acctcctaa  gatactggc  ttgctcgtg  gccacttgc  ggtgctgca  900
gtggccctg  tgttggaag  gcagctggc  gaggagtac  agcaggtgt  cctattccc  960
aagctcctg  tggattagc  ggccctgtc  gaggagttg  aggcccatc  cagcaggtc  1020
tgaccccac  gggaagagg  actgttgca  ctgctgctg  tgctgctac  gctagcatt  1080
caggagccc  aacccagta  ccgccagga  ggggaactc  acctccacc  gtaggcaga  1140
caaccccac  tccaggcat  atggctcct  cacctggaa  gagaccacc  atgggccca  1200
caattggac  tccccctgc  cgagggaca  ctataggca  gccccctcc  ggaatgaga  1260
cccctcctc  aggaattag  ggcccacct  ccccaggaa  gcgtccacc  agaccctaa  1320
atacagttg  taaatctca  cccttctct  tccctacaa  gcttcttgt  aaattgtgt  1380
gcctgcaag  ttttgaccc  tcttactgc  ttaactata  ataatacc  1428



<210> 3597
<211> 240
<212> PRT
<213> Rattus norvegicus
<308> P14648
<400> 3597

Met Thr Val Gly Lys Ser Ser Lys Met Leu Gln His Ile Asp Tyr Arg 
  1               5                  10                  15
Met Arg Cys Ile Leu Gln Asp Gly Arg Ile Phe Ile Gly Thr Phe Lys 
             20                  25                  30
Ala Phe Asp Lys His Met Asn Leu Ile Leu Cys Asp Cys Asp Glu Phe 
         35                  40                  45
Arg Lys Ile Lys Pro Lys Asn Ala Lys Gln Pro Glu Arg Glu Glu Lys 
     50                  55                  60
Arg Val Leu Gly Leu Val Leu Leu Arg Gly Glu Asn Leu Val Ser Met 
 65                  70                  75                  80
Thr Val Glu Gly Pro Pro Pro Lys Asp Thr Gly Ile Ala Arg Val Pro 
                 85                  90                  95
Leu Ala Gly Ala Ala Gly Gly Pro Gly Val Gly Arg Ala Ala Gly Arg 
             100                105                110
Gly Val Pro Ala Gly Val Pro Ile Pro Gln Ala Pro Ala Gly Leu Ala 
         115                120                125
Gly Pro Val Arg Gly Val Gly Gly Pro Ser Gln Gln Val Met Thr Pro 
     130                135                140
Gln Gly Arg Gly Thr Val Ala Ala Ala Ala Val Ala Ala Thr Ala Ser 
 145                150                155                160
Ile Ala Gly Ala Pro Thr Gln Tyr Pro Pro Gly Arg Gly Thr Pro Pro 
                 165                170                175
Pro Pro Val Gly Arg Ala Thr Pro Pro Pro Gly Ile Met Ala Pro Pro 
             180                185                190
Pro Gly Met Arg Pro Pro Met Gly Pro Pro Ile Gly Leu Pro Pro Ala 
         195                200                205
Arg Gly Thr Pro Ile Gly Met Pro Pro Pro Gly Met Arg Pro Pro Pro 
     210                215                220
Pro Gly Ile Arg Gly Pro Pro Pro Pro Gly Met Arg Pro Pro Arg Pro 
 225                230                235                240



<210> 3598
<211> 588
<212> DNA
<213> Homo sapiens
<308> AF319523
<400> 3598

gcggtcagt  acgcgatgg  gcgggcaag  gatcgctta  acctgagac  aactacaga  60
cagcacgta  cagaggtgg  agtccaagt  aaacgcaga  ggactgcct  actgagcaa  120
caagagtaa  gactccaca  ggaagaggc  ctgtagcag  tgctgctgt  gctgcgact  180
ccagtattg  tggagcccc  acacagtac  caccaggac  gggcactcc  cccccaccc  240
tcggcagag  aaccccacc  ccaggcatt  tggctcctc  acctggtat  agaccaccc  300
tgggcccac  aattgggct  ccccctgct  gagggacgc  aataggcat  ccgcctccg  360
gaatgagac  ccctccacc  ggcattaga  gggaagcat  tctccttgc  ttggtttgc  420
ggtatggat  gcccttaga  tttggcatg  gtgattatg  agcctattt  aagaaaacc  480
gttttctag  accttttta  ttaaatatr  cctgttaca  gagttaaag  caatcagga  540
gagtgaaaa  ttgatttgc  gctgacctg  aaatggaat  atcaggaa  588



<210> 3599
<211> 240
<212> PRT
<213> Homo sapiens
<308> P14648
<400> 3599

Met Thr Val Gly Lys Ser Ser Lys Met Leu Gln His Ile Asp Tyr Arg 
  1               5                  10                  15
Met Arg Cys Ile Leu Gln Asp Gly Arg Ile Phe Ile Gly Thr Phe Lys 
             20                  25                  30
Ala Phe Asp Lys His Met Asn Leu Ile Leu Cys Asp Cys Asp Glu Phe 
         35                  40                  45
Arg Lys Ile Lys Pro Lys Asn Ala Lys Gln Pro Glu Arg Glu Glu Lys 
     50                  55                  60
Arg Val Leu Gly Leu Val Leu Leu Arg Gly Glu Asn Leu Val Ser Met 
 65                  70                  75                  80
Thr Val Glu Gly Pro Pro Pro Lys Asp Thr Gly Ile Ala Arg Val Pro 
                 85                  90                  95
Leu Ala Gly Ala Ala Gly Gly Pro Gly Val Gly Arg Ala Ala Gly Arg 
             100                105                110
Gly Val Pro Ala Gly Val Pro Ile Pro Gln Ala Pro Ala Gly Leu Ala 
         115                120                125
Gly Pro Val Arg Gly Val Gly Gly Pro Ser Gln Gln Val Met Thr Pro 
     130                135                140
Gln Gly Arg Gly Thr Val Ala Ala Ala Ala Val Ala Ala Thr Ala Ser 
 145                150                155                160
Ile Ala Gly Ala Pro Thr Gln Tyr Pro Pro Gly Arg Gly Thr Pro Pro 
                 165                170                175
Pro Pro Val Gly Arg Ala Thr Pro Pro Pro Gly Ile Met Ala Pro Pro 
             180                185                190
Pro Gly Met Arg Pro Pro Met Gly Pro Pro Ile Gly Leu Pro Pro Ala 
         195                200                205
Arg Gly Thr Pro Ile Gly Met Pro Pro Pro Gly Met Arg Pro Pro Pro 
     210                215                220
Pro Gly Ile Arg Gly Pro Pro Pro Pro Gly Met Arg Pro Pro Arg Pro 
 225                230                235                240



<210> 3600
<211> 868
<212> DNA
<213> Rattus norvegicus
<308> M31032
<400> 3600

cagttggga  aaagtccat  gactcctcc  agatgcttg  ggtcctgct  acagcagcc  60
tgctggctc  gagctcagc  cagggcacg  atgaagagg  caacaatgc  gagaccagt  120
atgtaccag  agattctga  caacaaccc  tggactcgg  ttcagatcc  ccttctgct  180
atgcagatg  agagaatgt  caagagggt  aatcagccc  accagcaaa  gaagagcct  240
ctgccacct  tgggagtga  gaggaacag  agcagcagg  acccacaca  gcagagaat  300
aagagcctc  tgccacctc  gggagtgaa  aggaacagc  gcagcagga  cccacacag  360
cagagaatc  agagcctcc  gccacctct  ggagtgaag  ggaacagca  cagcagcaa  420
ccacacagg  agagaatca  gagcctcct  ccacctctg  gagtgaaga  gaacagcag  480
agcaggaat  cacacaggc  gagaatcaa  agccttctg  ctctgctgg  gaaggacag  540
aaactcaac  tgaggaagg  aatgtagag  cacctccct  ttctcctga  aactcacaa  600
aacaaccac  gcaaacaaa  ccagaggag  aaccgcctg  tcctaagac  caggaagag  660
cacagcact  tagaggtcg  cctccaaag  agatttttc  ttttttcat  tacagagga  720
gaccagtag  agtattcag  ctcgagcct  ggaatccat  cgccagaag  ttttagaga  780
tacctgaga  gattatgac  ttcagatgt  taggtcaac  aatcactgt  gattgtcta  840
aatattcca  taaaaattt  cagcatgc  868



<210> 3601
<211> 247
<212> PRT
<213> Rattus norvegicus
<308> AAA40969
<400> 3601

Met Leu Val Val Leu Leu Thr Ala Ala Leu Leu Ala Leu Ser Ser Ala 
  1               5                  10                  15
Gln Gly Thr Asp Glu Glu Val Asn Asn Ala Glu Thr Ser Asp Val Pro 
             20                  25                  30
Ala Asp Ser Glu Gln Gln Pro Val Asp Ser Gly Ser Asp Pro Pro Ser 
         35                  40                  45
Ala Asp Ala Asp Ala Glu Asn Val Gln Glu Gly Glu Ser Ala Pro Pro 
     50                  55                  60
Ala Asn Glu Glu Pro Pro Ala Thr Ser Gly Ser Glu Glu Glu Gln Gln 
 65                  70                  75                  80
Gln Gln Glu Pro Thr Gln Ala Glu Asn Gln Glu Pro Pro Ala Thr Ser 
                 85                  90                  95
Gly Ser Glu Glu Glu Gln Gln Gln Gln Glu Pro Thr Gln Ala Glu Asn 
             100                105                110
Gln Glu Pro Pro Ala Thr Ser Gly Ser Glu Glu Glu Gln Gln Gln Gln 
         115                120                125
Gln Pro Thr Gln Ala Glu Asn Gln Glu Pro Pro Ala Thr Ser Gly Ser 
     130                135                140
Glu Glu Glu Gln Gln Gln Gln Glu Ser Thr Gln Ala Glu Asn Gln Glu 
 145                150                155                160
Pro Ser Asp Ser Ala Gly Glu Gly Gln Glu Thr Gln Pro Glu Glu Gly 
                 165                170                175
Asn Val Glu Ser Pro Pro Ser Ser Pro Glu Asn Ser Gln Glu Gln Pro 
             180                185                190
Gln Gln Thr Asn Pro Glu Glu Lys Pro Pro Ala Pro Lys Thr Gln Glu 
         195                200                205
Glu Pro Gln His Tyr Arg Gly Arg Pro Pro Lys Lys Ile Phe Pro Phe 
     210                215                220
Phe Ile Tyr Arg Gly Arg Pro Val Val Val Phe Arg Leu Glu Pro Arg 
 225                230                235                240
Asn Pro Phe Ala Arg Arg Phe 
                 245



<210> 3602
<211> 507
<212> DNA
<213> Homo sapiens
<308> NM_007244
<400> 3602

cagagcctc  ttcaagatg  tgctggtcc  gctctcagt  gtccttctg  ctctgagct  60
agctcagag  acagataat  atgtgaact  tgaagactt  actttcacc  taccagatg  120
agaggactc  agtcagaga  cagatcagg  accccagag  cctcctcct  aaggactcc  180
acctagacc  cctggtgat  gtggtaacc  agatgatgg  cctcagcag  gaccaccaa  240
accaggagg  catcaccgc  atcctcccc  acctccttt  caaaatcag  aacgaccac  300
ccaacgagg  caccgtcaa  tctctctac  ccgatttcc  tctgtcagc  tgcaggaag  360
atcatcatt  ttccggagg  acagaccag  aagacatcc  caggagcaa  cactctggt  420
atctagaat  cagtggcag  aaataaata  gaagataac  tccttcaga  agccatgac  480
ttgaaataa  gtggtcata  ctctttc  507



<210> 3603
<211> 134
<212> PRT
<213> Homo sapiens
<308> Q16378
<400> 3603

Met Leu Leu Val Leu Leu Ser Val Val Leu Leu Ala Leu Ser Ser Ala 
  1               5                  10                  15
Gln Ser Thr Asp Asn Asp Val Asn Tyr Glu Asp Phe Thr Phe Thr Ile 
             20                  25                  30
Pro Asp Val Glu Asp Ser Ser Gln Arg Pro Asp Gln Gly Pro Gln Arg 
         35                  40                  45
Pro Pro Pro Glu Gly Leu Leu Pro Arg Pro Pro Gly Asp Ser Gly Asn 
     50                  55                  60
Gln Asp Asp Gly Pro Gln Gln Arg Pro Pro Lys Pro Gly Gly His His 
 65                  70                  75                  80
Arg His Pro Pro Pro Pro Pro Phe Gln Asn Gln Gln Arg Pro Pro Gln 
                 85                  90                  95
Arg Gly His Arg Gln Leu Ser Leu Pro Arg Phe Pro Ser Val Ser Leu 
             100                105                110
Gln Glu Ala Ser Ser Phe Phe Arg Arg Asp Arg Pro Ala Arg His Pro 
         115                120                125
Gln Glu Gln Pro Leu Trp 
     130



<210> 3604
<211> 868
<212> DNA
<213> Rattus norvegicus
<308> M31032
<400> 3604

cagttggga  aaagtccat  gactcctcc  agatgcttg  ggtcctgct  acagcagcc  60
tgctggctc  gagctcagc  cagggcacg  atgaagagg  caacaatgc  gagaccagt  120
atgtaccag  agattctga  caacaaccc  tggactcgg  ttcagatcc  ccttctgct  180
atgcagatg  agagaatgt  caagagggt  aatcagccc  accagcaaa  gaagagcct  240
ctgccacct  tgggagtga  gaggaacag  agcagcagg  acccacaca  gcagagaat  300
aagagcctc  tgccacctc  gggagtgaa  aggaacagc  gcagcagga  cccacacag  360
cagagaatc  agagcctcc  gccacctct  ggagtgaag  ggaacagca  cagcagcaa  420
ccacacagg  agagaatca  gagcctcct  ccacctctg  gagtgaaga  gaacagcag  480
agcaggaat  cacacaggc  gagaatcaa  agccttctg  ctctgctgg  gaaggacag  540
aaactcaac  tgaggaagg  aatgtagag  cacctccct  ttctcctga  aactcacaa  600
aacaaccac  gcaaacaaa  ccagaggag  aaccgcctg  tcctaagac  caggaagag  660
cacagcact  tagaggtcg  cctccaaag  agatttttc  ttttttcat  tacagagga  720
gaccagtag  agtattcag  ctcgagcct  ggaatccat  cgccagaag  ttttagaga  780
tacctgaga  gattatgac  ttcagatgt  taggtcaac  aatcactgt  gattgtcta  840
aatattcca  taaaaattt  cagcatgc  868



<210> 3605
<211> 247
<212> PRT
<213> Rattus norvegicus
<308> AAA40969
<400> 3605

Met Leu Val Val Leu Leu Thr Ala Ala Leu Leu Ala Leu Ser Ser Ala 
  1               5                  10                  15
Gln Gly Thr Asp Glu Glu Val Asn Asn Ala Glu Thr Ser Asp Val Pro 
             20                  25                  30
Ala Asp Ser Glu Gln Gln Pro Val Asp Ser Gly Ser Asp Pro Pro Ser 
         35                  40                  45
Ala Asp Ala Asp Ala Glu Asn Val Gln Glu Gly Glu Ser Ala Pro Pro 
     50                  55                  60
Ala Asn Glu Glu Pro Pro Ala Thr Ser Gly Ser Glu Glu Glu Gln Gln 
 65                  70                  75                  80
Gln Gln Glu Pro Thr Gln Ala Glu Asn Gln Glu Pro Pro Ala Thr Ser 
                 85                  90                  95
Gly Ser Glu Glu Glu Gln Gln Gln Gln Glu Pro Thr Gln Ala Glu Asn 
             100                105                110
Gln Glu Pro Pro Ala Thr Ser Gly Ser Glu Glu Glu Gln Gln Gln Gln 
         115                120                125
Gln Pro Thr Gln Ala Glu Asn Gln Glu Pro Pro Ala Thr Ser Gly Ser 
     130                135                140
Glu Glu Glu Gln Gln Gln Gln Glu Ser Thr Gln Ala Glu Asn Gln Glu 
 145                150                155                160
Pro Ser Asp Ser Ala Gly Glu Gly Gln Glu Thr Gln Pro Glu Glu Gly 
                 165                170                175
Asn Val Glu Ser Pro Pro Ser Ser Pro Glu Asn Ser Gln Glu Gln Pro 
             180                185                190
Gln Gln Thr Asn Pro Glu Glu Lys Pro Pro Ala Pro Lys Thr Gln Glu 
         195                200                205
Glu Pro Gln His Tyr Arg Gly Arg Pro Pro Lys Lys Ile Phe Pro Phe 
     210                215                220
Phe Ile Tyr Arg Gly Arg Pro Val Val Val Phe Arg Leu Glu Pro Arg 
 225                230                235                240
Asn Pro Phe Ala Arg Arg Phe 
                 245



<210> 3606
<211> 507
<212> DNA
<213> Homo sapiens
<308> NM_007244
<400> 3606

cagagcctc  ttcaagatg  tgctggtcc  gctctcagt  gtccttctg  ctctgagct  60
agctcagag  acagataat  atgtgaact  tgaagactt  actttcacc  taccagatg  120
agaggactc  agtcagaga  cagatcagg  accccagag  cctcctcct  aaggactcc  180
acctagacc  cctggtgat  gtggtaacc  agatgatgg  cctcagcag  gaccaccaa  240
accaggagg  catcaccgc  atcctcccc  acctccttt  caaaatcag  aacgaccac  300
ccaacgagg  caccgtcaa  tctctctac  ccgatttcc  tctgtcagc  tgcaggaag  360
atcatcatt  ttccggagg  acagaccag  aagacatcc  caggagcaa  cactctggt  420
atctagaat  cagtggcag  aaataaata  gaagataac  tccttcaga  agccatgac  480
ttgaaataa  gtggtcata  ctctttc  507



<210> 3607
<211> 134
<212> PRT
<213> Homo sapiens
<308> Q16378
<400> 3607

Met Leu Leu Val Leu Leu Ser Val Val Leu Leu Ala Leu Ser Ser Ala 
  1               5                  10                  15
Gln Ser Thr Asp Asn Asp Val Asn Tyr Glu Asp Phe Thr Phe Thr Ile 
             20                  25                  30
Pro Asp Val Glu Asp Ser Ser Gln Arg Pro Asp Gln Gly Pro Gln Arg 
         35                  40                  45
Pro Pro Pro Glu Gly Leu Leu Pro Arg Pro Pro Gly Asp Ser Gly Asn 
     50                  55                  60
Gln Asp Asp Gly Pro Gln Gln Arg Pro Pro Lys Pro Gly Gly His His 
 65                  70                  75                  80
Arg His Pro Pro Pro Pro Pro Phe Gln Asn Gln Gln Arg Pro Pro Gln 
                 85                  90                  95
Arg Gly His Arg Gln Leu Ser Leu Pro Arg Phe Pro Ser Val Ser Leu 
             100                105                110
Gln Glu Ala Ser Ser Phe Phe Arg Arg Asp Arg Pro Ala Arg His Pro 
         115                120                125
Gln Glu Gln Pro Leu Trp 
     130



<210> 3609
<211> 260
<212> PRT
<213> Rattus norvegicus
<308> P07171
<400> 3609

Ala Glu Ser His Leu Gln Ser Ser Leu Ile Thr Ala Ser Gln Phe Phe 
  1               5                  10                  15
Glu Ile Trp Leu His Phe Asp Ala Asp Gly Ser Gly Tyr Leu Glu Gly 
             20                  25                  30
Lys Glu Leu Gln Asn Leu Ile Gln Glu Leu Leu Gln Ala Arg Lys Lys 
         35                  40                  45
Ala Gly Leu Glu Leu Ser Pro Glu Met Lys Thr Phe Val Asp Gln Tyr 
     50                  55                  60
Gly Gln Arg Asp Asp Gly Lys Ile Gly Ile Val Glu Leu Ala His Val 
 65                  70                  75                  80
Leu Pro Thr Glu Glu Asn Phe Leu Leu Leu Phe Arg Cys Gln Gln Leu 
                 85                  90                  95
Lys Ser Cys Glu Glu Phe Met Lys Thr Trp Arg Lys Tyr Asp Thr Asp 
             100                105                110
His Ser Gly Phe Ile Glu Thr Glu Glu Leu Lys Asn Phe Leu Lys Asp 
         115                120                125
Leu Leu Glu Lys Ala Asn Lys Thr Val Asp Asp Thr Lys Leu Ala Glu 
     130                135                140
Tyr Thr Asp Leu Met Leu Lys Leu Phe Asp Ser Asn Asn Asp Gly Lys 
 145                150                155                160
Leu Glu Leu Thr Glu Met Ala Arg Leu Leu Pro Val Gln Glu Asn Phe 
                 165                170                175
Leu Leu Lys Phe Gln Gly Ile Lys Met Cys Gly Lys Glu Phe Asn Lys 
             180                185                190
Ala Phe Glu Leu Tyr Asp Gln Asp Gly Asn Gly Tyr Ile Asp Glu Asn 
         195                200                205
Glu Leu Asp Ala Leu Leu Lys Asp Leu Cys Glu Lys Asn Lys Gln Glu 
     210                215                220
Leu Asp Ile Asn Asn Ile Ser Thr Tyr Lys Lys Asn Ile Met Ala Leu 
 225                230                235                240
Ser Asp Gly Gly Lys Leu Tyr Arg Thr Asp Leu Ala Leu Ile Leu Ser 
                 245                250                255
Ala Gly Asp Asn 
             260



<210> 3610
<211> 2376
<212> DNA
<213> Homo sapiens
<308> X06661
<400> 3610

ccagacaca  accccgctg  acaatggca  aatcccacc  gcagtcatc  ctcatcaca  2340
cctcacagt  tttcgagat  tggctccat  tcgacg  2376



<210> 3611
<211> 260
<212> PRT
<213> Homo sapiens
<308> P05937
<400> 3611

Ala Glu Ser His Leu Gln Ser Ser Leu Ile Thr Ala Ser Gln Phe Phe 
  1               5                  10                  15
Glu Ile Trp Leu His Phe Asp Ala Asp Gly Ser Gly Tyr Leu Glu Gly 
             20                  25                  30
Lys Glu Leu Gln Asn Leu Ile Gln Glu Leu Gln Gln Ala Arg Lys Lys 
         35                  40                  45
Ala Gly Leu Glu Leu Ser Pro Glu Met Lys Thr Phe Val Asp Gln Tyr 
     50                  55                  60
Gly Gln Arg Asp Asp Gly Lys Ile Gly Ile Val Glu Leu Ala His Val 
 65                  70                  75                  80
Leu Pro Thr Glu Glu Asn Phe Leu Leu Leu Phe Arg Cys Gln Gln Leu 
                 85                  90                  95
Lys Ser Cys Glu Glu Phe Met Lys Thr Trp Arg Lys Tyr Asp Thr Asp 
             100                105                110
His Ser Gly Phe Ile Glu Thr Glu Glu Leu Lys Asn Phe Leu Lys Asp 
         115                120                125
Leu Leu Glu Lys Ala Asn Lys Thr Val Asp Asp Thr Lys Leu Ala Glu 
     130                135                140
Tyr Thr Asp Leu Met Leu Lys Leu Phe Asp Ser Asn Asn Asp Gly Lys 
 145                150                155                160
Leu Glu Leu Thr Glu Met Ala Arg Leu Leu Pro Val Gln Glu Asn Phe 
                 165                170                175
Leu Leu Lys Phe Gln Gly Ile Lys Met Cys Gly Lys Glu Phe Asn Lys 
             180                185                190
Ala Phe Glu Leu Tyr Asp Gln Asp Gly Asn Gly Tyr Ile Asp Glu Asn 
         195                200                205
Glu Leu Asp Ala Leu Leu Lys Asp Leu Cys Glu Lys Asn Lys Gln Asp 
     210                215                220
Leu Asp Ile Asn Asn Ile Thr Thr Tyr Lys Lys Asn Ile Met Ala Leu 
 225                230                235                240
Ser Asp Gly Gly Lys Leu Tyr Arg Thr Asp Leu Ala Leu Ile Leu Cys 
                 245                250                255
Ala Gly Asp Asn 
             260



<210> 3613
<211> 260
<212> PRT
<213> Rattus norvegicus
<308> P07171
<400> 3613

Ala Glu Ser His Leu Gln Ser Ser Leu Ile Thr Ala Ser Gln Phe Phe 
  1               5                  10                  15
Glu Ile Trp Leu His Phe Asp Ala Asp Gly Ser Gly Tyr Leu Glu Gly 
             20                  25                  30
Lys Glu Leu Gln Asn Leu Ile Gln Glu Leu Leu Gln Ala Arg Lys Lys 
         35                  40                  45
Ala Gly Leu Glu Leu Ser Pro Glu Met Lys Thr Phe Val Asp Gln Tyr 
     50                  55                  60
Gly Gln Arg Asp Asp Gly Lys Ile Gly Ile Val Glu Leu Ala His Val 
 65                  70                  75                  80
Leu Pro Thr Glu Glu Asn Phe Leu Leu Leu Phe Arg Cys Gln Gln Leu 
                 85                  90                  95
Lys Ser Cys Glu Glu Phe Met Lys Thr Trp Arg Lys Tyr Asp Thr Asp 
             100                105                110
His Ser Gly Phe Ile Glu Thr Glu Glu Leu Lys Asn Phe Leu Lys Asp 
         115                120                125
Leu Leu Glu Lys Ala Asn Lys Thr Val Asp Asp Thr Lys Leu Ala Glu 
     130                135                140
Tyr Thr Asp Leu Met Leu Lys Leu Phe Asp Ser Asn Asn Asp Gly Lys 
 145                150                155                160
Leu Glu Leu Thr Glu Met Ala Arg Leu Leu Pro Val Gln Glu Asn Phe 
                 165                170                175
Leu Leu Lys Phe Gln Gly Ile Lys Met Cys Gly Lys Glu Phe Asn Lys 
             180                185                190
Ala Phe Glu Leu Tyr Asp Gln Asp Gly Asn Gly Tyr Ile Asp Glu Asn 
         195                200                205
Glu Leu Asp Ala Leu Leu Lys Asp Leu Cys Glu Lys Asn Lys Gln Glu 
     210                215                220
Leu Asp Ile Asn Asn Ile Ser Thr Tyr Lys Lys Asn Ile Met Ala Leu 
 225                230                235                240
Ser Asp Gly Gly Lys Leu Tyr Arg Thr Asp Leu Ala Leu Ile Leu Ser 
                 245                250                255
Ala Gly Asp Asn 
             260



<210> 3614
<211> 2376
<212> DNA
<213> Homo sapiens
<308> X06661
<400> 3614

ccagacaca  accccgctg  acaatggca  aatcccacc  gcagtcatc  ctcatcaca  2340
cctcacagt  tttcgagat  tggctccat  tcgacg  2376



<210> 3615
<211> 260
<212> PRT
<213> Homo sapiens
<308> P05937
<400> 3615

Ala Glu Ser His Leu Gln Ser Ser Leu Ile Thr Ala Ser Gln Phe Phe 
  1               5                  10                  15
Glu Ile Trp Leu His Phe Asp Ala Asp Gly Ser Gly Tyr Leu Glu Gly 
             20                  25                  30
Lys Glu Leu Gln Asn Leu Ile Gln Glu Leu Gln Gln Ala Arg Lys Lys 
         35                  40                  45
Ala Gly Leu Glu Leu Ser Pro Glu Met Lys Thr Phe Val Asp Gln Tyr 
     50                  55                  60
Gly Gln Arg Asp Asp Gly Lys Ile Gly Ile Val Glu Leu Ala His Val 
 65                  70                  75                  80
Leu Pro Thr Glu Glu Asn Phe Leu Leu Leu Phe Arg Cys Gln Gln Leu 
                 85                  90                  95
Lys Ser Cys Glu Glu Phe Met Lys Thr Trp Arg Lys Tyr Asp Thr Asp 
             100                105                110
His Ser Gly Phe Ile Glu Thr Glu Glu Leu Lys Asn Phe Leu Lys Asp 
         115                120                125
Leu Leu Glu Lys Ala Asn Lys Thr Val Asp Asp Thr Lys Leu Ala Glu 
     130                135                140
Tyr Thr Asp Leu Met Leu Lys Leu Phe Asp Ser Asn Asn Asp Gly Lys 
 145                150                155                160
Leu Glu Leu Thr Glu Met Ala Arg Leu Leu Pro Val Gln Glu Asn Phe 
                 165                170                175
Leu Leu Lys Phe Gln Gly Ile Lys Met Cys Gly Lys Glu Phe Asn Lys 
             180                185                190
Ala Phe Glu Leu Tyr Asp Gln Asp Gly Asn Gly Tyr Ile Asp Glu Asn 
         195                200                205
Glu Leu Asp Ala Leu Leu Lys Asp Leu Cys Glu Lys Asn Lys Gln Asp 
     210                215                220
Leu Asp Ile Asn Asn Ile Thr Thr Tyr Lys Lys Asn Ile Met Ala Leu 
 225                230                235                240
Ser Asp Gly Gly Lys Leu Tyr Arg Thr Asp Leu Ala Leu Ile Leu Cys 
                 245                250                255
Ala Gly Asp Asn 
             260



<210> 3616
<211> 1675
<212> DNA
<213> Rattus norvegicus
<308> M31788
<400> 3616

ggcctctct  cgggcctct  gacctcacg  tgttgccaa  atgtcgctt  ctaacaagc  60
gactttgga  aagctggac  tgaagggga  gcgggtcgt  atgagggtg  acttcaatg  120
tcctatgaa  aacaaccag  taacgaata  ccaaaggat  aaggctgct  tcccaagca  180
caaattctg  ttggacaat  gagccaact  ggttgtgct  atgagccac  tgggccgtc  240
tgatggtgt  cccatgccc  acaagtact  cttagagcc  gttgctgca  aactcaaat  300
tctgctggg  aaggatgtt  tgttcttga  ggattgtgt  ggctcagaa  tagagaatg  360
ctgtgccaa  ccagcggct  ggactgtca  cctcctgga  aacctccgc  ttcatgtag  420
ggaagaagg  aagggaaaa  atgcttctg  gaacaaggt  aaagctgag  cagctaaaa  480
tgatgcttt  cgagcctcc  tgtccaaac  tggagatgt  tatgtcaat  atgcttttg  540
gactgcaca  agagcccac  gttccatgg  gggtgtgaa  ctgccacag  aggctggtg  600
atttttgat  aagaaggag  tgaactact  tgccaaggc  ttggagagt  cagagcgac  660
cttcctggc  atcttggga  gagctaaag  tgcagacaa  atccagctg  tcaataata  720
gctagacaa  gtcaatgag  tgatcatcg  tgggggaat  gcttttacc  tccttaagg  780
gctcaacaa  atggagatt  gcacatctc  gtatgatga  gagggagcc  agattgtca  840
agatctcat  accaaagct  agaaaaatg  tgtgaagat  accttgcct  ttgactttg  900
cactgctga  aaatttgat  agaatgcaa  gactggcca  gctactgtg  cctctggta  960
acctgctgg  tggatgggc  tggactgtg  tactgagag  agtaagaaa  atgctgagg  1020
tgtggctcg  gctaagcag  ttgtttgga  cggccctgt  ggggtattt  aatgggaag  1080
atttgccag  ggaaccaag  ccctcatgg  tgaggtggt  aaagccacg  ctaggggct  1140
catcactat  ataggtggt  gagacaccg  cacttgctg  gccaaatgg  acacagagg  1200
taaagtcag  catgtgagc  ctgggggcg  cgccagttt  gagctcctg  aaggtaaag  1260
ccttcctgg  gtggatgct  tcagcaatg  ttagtattt  cctgccttt  ggttcctgt  1320
cacagcccc  aagtcgact  agtgttttc  gcatctcca  ttggtgtta  tgcagctag  1380
ggccaagac  agcaccagg  acctaagca  cagctgcac  gcatctcag  tcgtcttta  1440
tgcatggga  tcattatag  taagtccat  taatttctt  gtgactaaa  cttgcatta  1500
ggcatatat  tatactctg  ctgtgaaag  aagtgagct  taaaagctt  gctctcttc  1560
ctgtatgta  cctctggtt  gcctgtcac  gttcatgac  gcatggaaa  aacgatgag  1620
attccagct  taggtttgg  aggttgatg  tattgaacc  ataaaagat  ccact  1675



<210> 3617
<211> 416
<212> PRT
<213> Rattus norvegicus
<308> P16617
<400> 3617

Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys Gly Lys 
  1               5                  10                  15
Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn Asn Gln 
             20                  25                  30
Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile Lys Phe 
         35                  40                  45
Cys Leu Asp Asn Gly Ala Asn Ser Val Val Leu Met Ser His Leu Gly 
     50                  55                  60
Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro Val 
 65                  70                  75                  80
Ala Ala Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu Lys 
                 85                  90                  95
Asp Cys Val Gly Ser Glu Val Glu Asn Ala Cys Ala Asn Pro Ala Ala 
             100                105                110
Gly Thr Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu Glu 
         115                120                125
Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu Pro Ala 
     130                135                140
Lys Ile Asp Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val Tyr 
 145                150                155                160
Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met Val 
                 165                170                175
Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys Glu 
             180                185                190
Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe Leu 
         195                200                205
Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile Asn 
     210                215                220
Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met Ala 
 225                230                235                240
Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser Leu 
                 245                250                255
Tyr Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Thr Lys Ala 
             260                265                270
Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val Thr Ala 
         275                280                285
Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val Ala Ser 
     290                295                300
Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Thr Glu Ser Ser 
 305                310                315                320
Lys Lys Tyr Ala Glu Ala Val Ala Arg Ala Lys Gln Ile Val Trp Asn 
                 325                330                335
Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr Lys 
             340                345                350
Ser Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys Ile Thr 
         355                360                365
Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn Thr 
     370                375                380
Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu Glu 
 385                390                395                400
Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala Leu Ser Asn Val 
                 405                410                415



<210> 3618
<211> 1767
<212> DNA
<213> Homo sapiens
<308> NM_000291
<400> 3618

aagcctccg  agcgcacgt  ggcagtcgg  tccctcgtt  accgaatca  cgacctctc  60
ccccagctg  atttccaaa  tgtcgcttt  taacaagct  acgctggac  agctggacg  120
taaagggaa  cgggtcgtt  tgagagtcg  cttcaatgt  cctatgaag  acaaccaga  180
aacaaacaa  cagaggatt  aggctgctg  cccaagcat  aaattctgc  tggacaatg  240
agccaagtc  gtagtcctt  tgagccacc  aggccggcc  gatggtgtg  ccatgcctg  300
caagtactc  ttagagcca  ttgctgtag  actcaaatc  ctgctgggc  aggatgttc  360
gttcttgaa  gactgtgta  gcccagaag  ggagaaagc  tgtgccaac  cagctgctg  420
gtctgtcat  ctgctggag  acctccgct  tcatgtgga  gaagaaggg  agggaaaag  480
tgcttctgg  aacaaggtt  aagccgagc  agccaaaat  gaagctttc  gagcttcac  540
ttccaagct  ggggatgtc  atgtcaatg  tgcttttgg  actgctcac  gagcccaca  600
ctccatggt  ggagtcaat  tgccacaga  ggctggtgg  tttttgatg  agaaggagc  660
gaactactt  gcaaaggcc  tggagagcc  agagcgacc  ttcctggcc  tcctgggcg  720
agctaaagt  gcagacaag  tccagctca  caataatat  ctggacaaa  tcaatgaga  780
gattattgg  ggtggaatg  cttttacct  ccttaaggt  ctcaacaac  tggagattg  840
cacttctct  tttgatgaa  agggagcca  gattgtcaa  gacctaatg  ccaaagctg  900
gaagaatgg  gtgaagatt  ccttgcctg  tgactttgt  actgctgac  agtttgatg  960
gaatgccaa  actggccaa  ccactgtgg  ttctggcat  cctgctggc  ggatgggct  1020
ggactgtgg  cctgaaagc  gcaagaagt  tgctgaggc  gtcactcgg  ctaagcaga  1080
tgtgtggaa  ggtcctgtg  gggtatttg  atgggaagc  tttgcccgg  gaaccaaag  1140
tctcatgga  gaggtggtg  aagccactt  taggggctg  atcaccatc  taggtggtg  1200
agacactgc  acttgctgt  ccaaatgga  cacggagga  aaagtcagc  atgtgagca  1260
tgggggtgg  gccagtttg  agctcctgg  aggtaaagt  cttcctggg  tggatgctc  1320
cagcaatat  tagtacttt  ctgcctttt  gttcctgtg  acagcccct  agtcaactt  1380
gcattttct  catctccac  tggcattag  taaaacctt  catgtcaag  ttcagctag  1440
ggccaagag  tgcagtgcc  ggaaccctt  aacagttgc  cagcatctc  gctcatctt  1500
actgcaccc  ggatttgca  acattcttc  agatcccat  tgaattttt  agtgactaa  1560
ccattgtgc  ttctagagt  catatattt  tattttgcc  gttaaaaag  aagtgagca  1620
tgttagctt  gttctcttt  gatgtaggt  attatgatt  gctttgtca  tgtttcact  1680
ctcagcatg  aaacaagat  aaattccat  tgtaggtag  gagacaaaa  tgatgatcc  1740
ttaagtaaa  aataaaagt  tccattg  1767



<210> 3619
<211> 417
<212> PRT
<213> Homo sapiens
<308> P00558
<400> 3619

Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys Gly Lys 
  1               5                  10                  15
Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn Asn Gln 
             20                  25                  30
Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile Lys Phe 
         35                  40                  45
Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu Met Ser His Leu Gly 
     50                  55                  60
Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro Val 
 65                  70                  75                  80
Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu Lys 
                 85                  90                  95
Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys Ala Asn Pro Ala Ala 
             100                105                110
Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu Glu 
         115                120                125
Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu Pro Ala 
     130                135                140
Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val Tyr 
 145                150                155                160
Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met Val 
                 165                170                175
Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys Glu 
             180                185                190
Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe Leu 
         195                200                205
Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile Asn 
     210                215                220
Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met Ala 
 225                230                235                240
Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser Leu 
                 245                250                255
Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Ser Lys Ala 
             260                265                270
Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val Thr Ala 
         275                280                285
Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val Ala Ser 
     290                295                300
Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Pro Glu Ser Ser 
 305                310                315                320
Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys Gln Ile Val Trp Asn 
                 325                330                335
Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr Lys 
             340                345                350
Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys Ile Thr 
         355                360                365
Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn Thr 
     370                375                380
Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu Glu 
 385                390                395                400
Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala Leu Ser Asn Ile 
                 405                410                415
Leu 
             420



<210> 3620
<211> 1675
<212> DNA
<213> Rattus norvegicus
<308> M31788
<400> 3620

ggcctctct  cgggcctct  gacctcacg  tgttgccaa  atgtcgctt  ctaacaagc  60
gactttgga  aagctggac  tgaagggga  gcgggtcgt  atgagggtg  acttcaatg  120
tcctatgaa  aacaaccag  taacgaata  ccaaaggat  aaggctgct  tcccaagca  180
caaattctg  ttggacaat  gagccaact  ggttgtgct  atgagccac  tgggccgtc  240
tgatggtgt  cccatgccc  acaagtact  cttagagcc  gttgctgca  aactcaaat  300
tctgctggg  aaggatgtt  tgttcttga  ggattgtgt  ggctcagaa  tagagaatg  360
ctgtgccaa  ccagcggct  ggactgtca  cctcctgga  aacctccgc  ttcatgtag  420
ggaagaagg  aagggaaaa  atgcttctg  gaacaaggt  aaagctgag  cagctaaaa  480
tgatgcttt  cgagcctcc  tgtccaaac  tggagatgt  tatgtcaat  atgcttttg  540
gactgcaca  agagcccac  gttccatgg  gggtgtgaa  ctgccacag  aggctggtg  600
atttttgat  aagaaggag  tgaactact  tgccaaggc  ttggagagt  cagagcgac  660
cttcctggc  atcttggga  gagctaaag  tgcagacaa  atccagctg  tcaataata  720
gctagacaa  gtcaatgag  tgatcatcg  tgggggaat  gcttttacc  tccttaagg  780
gctcaacaa  atggagatt  gcacatctc  gtatgatga  gagggagcc  agattgtca  840
agatctcat  accaaagct  agaaaaatg  tgtgaagat  accttgcct  ttgactttg  900
cactgctga  aaatttgat  agaatgcaa  gactggcca  gctactgtg  cctctggta  960
acctgctgg  tggatgggc  tggactgtg  tactgagag  agtaagaaa  atgctgagg  1020
tgtggctcg  gctaagcag  ttgtttgga  cggccctgt  ggggtattt  aatgggaag  1080
atttgccag  ggaaccaag  ccctcatgg  tgaggtggt  aaagccacg  ctaggggct  1140
catcactat  ataggtggt  gagacaccg  cacttgctg  gccaaatgg  acacagagg  1200
taaagtcag  catgtgagc  ctgggggcg  cgccagttt  gagctcctg  aaggtaaag  1260
ccttcctgg  gtggatgct  tcagcaatg  ttagtattt  cctgccttt  ggttcctgt  1320
cacagcccc  aagtcgact  agtgttttc  gcatctcca  ttggtgtta  tgcagctag  1380
ggccaagac  agcaccagg  acctaagca  cagctgcac  gcatctcag  tcgtcttta  1440
tgcatggga  tcattatag  taagtccat  taatttctt  gtgactaaa  cttgcatta  1500
ggcatatat  tatactctg  ctgtgaaag  aagtgagct  taaaagctt  gctctcttc  1560
ctgtatgta  cctctggtt  gcctgtcac  gttcatgac  gcatggaaa  aacgatgag  1620
attccagct  taggtttgg  aggttgatg  tattgaacc  ataaaagat  ccact  1675



<210> 3621
<211> 416
<212> PRT
<213> Rattus norvegicus
<308> P16617
<400> 3621

Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys Gly Lys 
  1               5                  10                  15
Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn Asn Gln 
             20                  25                  30
Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile Lys Phe 
         35                  40                  45
Cys Leu Asp Asn Gly Ala Asn Ser Val Val Leu Met Ser His Leu Gly 
     50                  55                  60
Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro Val 
 65                  70                  75                  80
Ala Ala Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu Lys 
                 85                  90                  95
Asp Cys Val Gly Ser Glu Val Glu Asn Ala Cys Ala Asn Pro Ala Ala 
             100                105                110
Gly Thr Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu Glu 
         115                120                125
Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu Pro Ala 
     130                135                140
Lys Ile Asp Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val Tyr 
 145                150                155                160
Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met Val 
                 165                170                175
Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys Glu 
             180                185                190
Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe Leu 
         195                200                205
Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile Asn 
     210                215                220
Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met Ala 
 225                230                235                240
Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser Leu 
                 245                250                255
Tyr Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Thr Lys Ala 
             260                265                270
Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val Thr Ala 
         275                280                285
Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val Ala Ser 
     290                295                300
Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Thr Glu Ser Ser 
 305                310                315                320
Lys Lys Tyr Ala Glu Ala Val Ala Arg Ala Lys Gln Ile Val Trp Asn 
                 325                330                335
Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr Lys 
             340                345                350
Ser Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys Ile Thr 
         355                360                365
Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn Thr 
     370                375                380
Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu Glu 
 385                390                395                400
Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala Leu Ser Asn Val 
                 405                410                415



<210> 3622
<211> 1767
<212> DNA
<213> Homo sapiens
<308> NM_000291
<400> 3622

aagcctccg  agcgcacgt  ggcagtcgg  tccctcgtt  accgaatca  cgacctctc  60
ccccagctg  atttccaaa  tgtcgcttt  taacaagct  acgctggac  agctggacg  120
taaagggaa  cgggtcgtt  tgagagtcg  cttcaatgt  cctatgaag  acaaccaga  180
aacaaacaa  cagaggatt  aggctgctg  cccaagcat  aaattctgc  tggacaatg  240
agccaagtc  gtagtcctt  tgagccacc  aggccggcc  gatggtgtg  ccatgcctg  300
caagtactc  ttagagcca  ttgctgtag  actcaaatc  ctgctgggc  aggatgttc  360
gttcttgaa  gactgtgta  gcccagaag  ggagaaagc  tgtgccaac  cagctgctg  420
gtctgtcat  ctgctggag  acctccgct  tcatgtgga  gaagaaggg  agggaaaag  480
tgcttctgg  aacaaggtt  aagccgagc  agccaaaat  gaagctttc  gagcttcac  540
ttccaagct  ggggatgtc  atgtcaatg  tgcttttgg  actgctcac  gagcccaca  600
ctccatggt  ggagtcaat  tgccacaga  ggctggtgg  tttttgatg  agaaggagc  660
gaactactt  gcaaaggcc  tggagagcc  agagcgacc  ttcctggcc  tcctgggcg  720
agctaaagt  gcagacaag  tccagctca  caataatat  ctggacaaa  tcaatgaga  780
gattattgg  ggtggaatg  cttttacct  ccttaaggt  ctcaacaac  tggagattg  840
cacttctct  tttgatgaa  agggagcca  gattgtcaa  gacctaatg  ccaaagctg  900
gaagaatgg  gtgaagatt  ccttgcctg  tgactttgt  actgctgac  agtttgatg  960
gaatgccaa  actggccaa  ccactgtgg  ttctggcat  cctgctggc  ggatgggct  1020
ggactgtgg  cctgaaagc  gcaagaagt  tgctgaggc  gtcactcgg  ctaagcaga  1080
tgtgtggaa  ggtcctgtg  gggtatttg  atgggaagc  tttgcccgg  gaaccaaag  1140
tctcatgga  gaggtggtg  aagccactt  taggggctg  atcaccatc  taggtggtg  1200
agacactgc  acttgctgt  ccaaatgga  cacggagga  aaagtcagc  atgtgagca  1260
tgggggtgg  gccagtttg  agctcctgg  aggtaaagt  cttcctggg  tggatgctc  1320
cagcaatat  tagtacttt  ctgcctttt  gttcctgtg  acagcccct  agtcaactt  1380
gcattttct  catctccac  tggcattag  taaaacctt  catgtcaag  ttcagctag  1440
ggccaagag  tgcagtgcc  ggaaccctt  aacagttgc  cagcatctc  gctcatctt  1500
actgcaccc  ggatttgca  acattcttc  agatcccat  tgaattttt  agtgactaa  1560
ccattgtgc  ttctagagt  catatattt  tattttgcc  gttaaaaag  aagtgagca  1620
tgttagctt  gttctcttt  gatgtaggt  attatgatt  gctttgtca  tgtttcact  1680
ctcagcatg  aaacaagat  aaattccat  tgtaggtag  gagacaaaa  tgatgatcc  1740
ttaagtaaa  aataaaagt  tccattg  1767



<210> 3623
<211> 417
<212> PRT
<213> Homo sapiens
<308> P00558
<400> 3623

Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys Gly Lys 
  1               5                  10                  15
Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn Asn Gln 
             20                  25                  30
Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile Lys Phe 
         35                  40                  45
Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu Met Ser His Leu Gly 
     50                  55                  60
Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro Val 
 65                  70                  75                  80
Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu Lys 
                 85                  90                  95
Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys Ala Asn Pro Ala Ala 
             100                105                110
Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu Glu 
         115                120                125
Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu Pro Ala 
     130                135                140
Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val Tyr 
 145                150                155                160
Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met Val 
                 165                170                175
Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys Glu 
             180                185                190
Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe Leu 
         195                200                205
Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile Asn 
     210                215                220
Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met Ala 
 225                230                235                240
Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser Leu 
                 245                250                255
Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Ser Lys Ala 
             260                265                270
Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val Thr Ala 
         275                280                285
Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val Ala Ser 
     290                295                300
Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Pro Glu Ser Ser 
 305                310                315                320
Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys Gln Ile Val Trp Asn 
                 325                330                335
Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr Lys 
             340                345                350
Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys Ile Thr 
         355                360                365
Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn Thr 
     370                375                380
Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu Glu 
 385                390                395                400
Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala Leu Ser Asn Ile 
                 405                410                415
Leu 
             420



<210> 3624
<211> 1341
<212> DNA
<213> Rattus norvegicus
<308> M32062
<400> 3624

ccagcaatt  catctccta  acctcatca  actctgacc  agttcttga  tgactttgg  60
gacccagat  tttcagaat  cacattctg  aagccaatg  ctactccca  cactgacaa  120
gttgctgct  tttgctttt  cagacaggc  gacgggaga  cttctgaag  ctgtggtga  180
acgtgatcc  ccatggatc  aggtgctca  ggacgacac  gtgacgctg  cgtgcgaag  240
gacccacaa  cctggaaac  cttctaccc  gtggttcca  aaccagagc  ccacctggg  300
ccaggtcca  gccagctac  cgtttaagg  cacagtcaa  gacagtgga  aataccggt  360
ccgaatggc  cacaccagc  tcagcgacc  catacatct  gaagtgatt  ctgactggc  420
gctgctcca  acccctcaa  tggtgtttg  ggaagggga  accatcaca  taaggtgcc  480
tagctggaa  aacaaacag  tgactaagg  cttgttgtt  cagaatgga  aacctgtga  540
gtattatta  caaagcagc  atttttcaa  ccccaaagc  aaccacagt  acagtggga  600
ctactactg  aaagcatat  taggaagga  aatgcatgt  tccaagcct  tcaccatca  660
tgtccaagg  tcagcaacc  cgtccacca  ctctctagt  tggttccat  ccgctttct  720
cctagtgat  tgcctcctg  ttgcagtgg  caccggcct  tatttctgt  tacggagaa  780
tcttcaaac  tcgggggag  actggagga  atccctgtc  gtcggaaag  acaaggctc  840
acaggacaa  tgacatccc  tcgtatggc  aaacagcgg  agcttcttt  cagccacac  900
gccgcttca  ctacagcct  cctttgaaa  caacttacc  ccaggctgg  tatttggtc  960
tgcaatcac  actgctagg  ggctgaggc  ggaggatca  caaaggctg  ccgggtttt  1020
gagaagaga  agtgcaagt  tatcctgga  aacccaata  gaccctggg  ttagatggc  1080
tatcaggaa  gagcaccca  tgctaagct  acagacaag  ccacagatt  atccctaag  1140
acacagggc  aagggggag  acaaattcc  gaaagttgt  ctctgacct  cacacgtcc  1200
ccatggcag  tgcacacaa  aaacaaatt  aaatgtaat  tatatattt  aaacaagag  1260
tggggaaag  ctgggggtt  gtggcacag  ttttatcca  gacacatga  gctctggat  1320
ttgacctcc  ataataaaa  g  1341



<210> 3625
<211> 267
<212> PRT
<213> Rattus norvegicus
<308> P27645
<400> 3625

Met Thr Leu Glu Thr Gln Met Phe Gln Asn Ala His Ser Gly Ser Gln 
  1               5                  10                  15
Trp Leu Leu Pro Pro Leu Thr Met Leu Leu Leu Phe Ala Phe Ala Asp 
             20                  25                  30
Arg Gln Thr Ala Asn Leu Pro Lys Ala Val Val Lys Arg Asp Pro Pro 
         35                  40                  45
Trp Ile Gln Val Leu Lys Glu Asp Thr Val Thr Leu Thr Cys Glu Gly 
     50                  55                  60
Thr His Asn Pro Gly Asn Ser Ser Thr Gln Trp Phe His Asn Gln Ser 
 65                  70                  75                  80
Ser Thr Trp Gly Gln Val Gln Ala Ser Tyr Thr Phe Lys Ala Thr Val 
                 85                  90                  95
Asn Asp Ser Gly Glu Tyr Arg Cys Arg Met Ala His Thr Ser Leu Ser 
             100                105                110
Asp Pro Val His Leu Glu Val Ile Ser Asp Trp Leu Leu Leu Gln Thr 
         115                120                125
Pro Gln Leu Val Phe Glu Glu Gly Glu Thr Ile Thr Leu Arg Cys His 
     130                135                140
Ser Trp Lys Asn Lys Gln Leu Thr Lys Val Leu Leu Phe Gln Asn Gly 
 145                150                155                160
Lys Pro Val Arg Tyr Tyr Tyr Gln Ser Ser Asn Phe Ser Ile Pro Lys 
                 165                170                175
Ala Asn His Ser His Ser Gly Asn Tyr Tyr Cys Lys Ala Tyr Leu Gly 
             180                185                190
Arg Thr Met His Val Ser Lys Pro Val Thr Ile Thr Val Gln Gly Ser 
         195                200                205
Ala Thr Ala Ser Thr Ser Ser Leu Val Trp Phe His Ala Ala Phe Cys 
     210                215                220
Leu Val Met Cys Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Cys 
 225                230                235                240
Val Arg Arg Asn Leu Gln Thr Ser Gly Glu Asp Trp Arg Lys Ser Leu 
                 245                250                255
Ser Val Gly Lys Tyr Lys Ala Pro Gln Asp Lys 
             260                265



<210> 3626
<211> 634
<212> DNA
<213> Homo sapiens
<308> AV703731
<400> 3626

caggagaaa  aacactatg  taatttcat  gttacttga  gtctctttc  atctgaaga  60
ctgggttgt  tggagaatt  aacatagcc  agcaatatt  tcaattagt  atgtcatct  120
aaaaatgtt  acttttact  agttttatt  agaggatct  tgtattatt  gaaaaatga  180
gtatttctg  catggaaca  agaaagtgg  aactggtac  taatggggg  agcaaaatt  240
gctgggact  aaacggaca  gttttgttt  gtgaattct  cctaaatgt  tctctatcc  300
cagagaaac  agtattact  gaagatgtg  aagttcctg  ggtagccat  ccttgaagc  360
cagtgtttg  acataagta  atatcttga  tctaaatta  atccagatt  aactaatat  420
tattatttt  tatctttgt  gtattaaaa  gtttaaaaa  actaaaaat  aaacatttg  480
aagttggat  acaaaaaaa  aaaaaaaaa  ctcgagggg  ggcccggta  ccacttcgc  540
ctatagtga  tcgtattac  attcactgg  ccgccgttt  caacgtcgt  actggggct  600
cgtaataac  aagaggccc  caccggtcg  cttt  634



<210> 3627
<211> 317
<212> PRT
<213> Homo sapiens
<308> AAA35827
<400> 3627

Met Ala Met Glu Thr Gln Met Ser Gln Asn Val Cys Pro Arg Asn Leu 
  1               5                  10                  15
Trp Leu Leu Gln Pro Leu Thr Val Leu Leu Leu Leu Ala Ser Ala Asp 
             20                  25                  30
Ser Gln Ala Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro 
         35                  40                  45
Trp Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly 
     50                  55                  60
Ala Arg Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn 
 65                  70                  75                  80
Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn 
                 85                  90                  95
Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser 
             100                105                110
Asp Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr 
         115                120                125
Pro His Leu Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His 
     130                135                140
Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly 
 145                150                155                160
Lys Ser Gln Lys Phe Ser Arg Leu Asp Pro Thr Phe Ser Ile Pro Gln 
                 165                170                175
Ala Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly 
             180                185                190
Tyr Thr Leu Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val Pro 
         195                200                205
Ser Met Gly Ser Ser Ser Pro Met Gly Ile Ile Val Ala Val Val Ile 
     210                215                220
Ala Thr Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr 
 225                230                235                240
Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
                 245                250                255
Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
             260                265                270
Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
         275                280                285
Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
     290                295                300
Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
 305                310                315



<210> 3628
<211> 1341
<212> DNA
<213> Rattus norvegicus
<308> M32062
<400> 3628

ccagcaatt  catctccta  acctcatca  actctgacc  agttcttga  tgactttgg  60
gacccagat  tttcagaat  cacattctg  aagccaatg  ctactccca  cactgacaa  120
gttgctgct  tttgctttt  cagacaggc  gacgggaga  cttctgaag  ctgtggtga  180
acgtgatcc  ccatggatc  aggtgctca  ggacgacac  gtgacgctg  cgtgcgaag  240
gacccacaa  cctggaaac  cttctaccc  gtggttcca  aaccagagc  ccacctggg  300
ccaggtcca  gccagctac  cgtttaagg  cacagtcaa  gacagtgga  aataccggt  360
ccgaatggc  cacaccagc  tcagcgacc  catacatct  gaagtgatt  ctgactggc  420
gctgctcca  acccctcaa  tggtgtttg  ggaagggga  accatcaca  taaggtgcc  480
tagctggaa  aacaaacag  tgactaagg  cttgttgtt  cagaatgga  aacctgtga  540
gtattatta  caaagcagc  atttttcaa  ccccaaagc  aaccacagt  acagtggga  600
ctactactg  aaagcatat  taggaagga  aatgcatgt  tccaagcct  tcaccatca  660
tgtccaagg  tcagcaacc  cgtccacca  ctctctagt  tggttccat  ccgctttct  720
cctagtgat  tgcctcctg  ttgcagtgg  caccggcct  tatttctgt  tacggagaa  780
tcttcaaac  tcgggggag  actggagga  atccctgtc  gtcggaaag  acaaggctc  840
acaggacaa  tgacatccc  tcgtatggc  aaacagcgg  agcttcttt  cagccacac  900
gccgcttca  ctacagcct  cctttgaaa  caacttacc  ccaggctgg  tatttggtc  960
tgcaatcac  actgctagg  ggctgaggc  ggaggatca  caaaggctg  ccgggtttt  1020
gagaagaga  agtgcaagt  tatcctgga  aacccaata  gaccctggg  ttagatggc  1080
tatcaggaa  gagcaccca  tgctaagct  acagacaag  ccacagatt  atccctaag  1140
acacagggc  aagggggag  acaaattcc  gaaagttgt  ctctgacct  cacacgtcc  1200
ccatggcag  tgcacacaa  aaacaaatt  aaatgtaat  tatatattt  aaacaagag  1260
tggggaaag  ctgggggtt  gtggcacag  ttttatcca  gacacatga  gctctggat  1320
ttgacctcc  ataataaaa  g  1341



<210> 3629
<211> 267
<212> PRT
<213> Rattus norvegicus
<308> P27645
<400> 3629

Met Thr Leu Glu Thr Gln Met Phe Gln Asn Ala His Ser Gly Ser Gln 
  1               5                  10                  15
Trp Leu Leu Pro Pro Leu Thr Met Leu Leu Leu Phe Ala Phe Ala Asp 
             20                  25                  30
Arg Gln Thr Ala Asn Leu Pro Lys Ala Val Val Lys Arg Asp Pro Pro 
         35                  40                  45
Trp Ile Gln Val Leu Lys Glu Asp Thr Val Thr Leu Thr Cys Glu Gly 
     50                  55                  60
Thr His Asn Pro Gly Asn Ser Ser Thr Gln Trp Phe His Asn Gln Ser 
 65                  70                  75                  80
Ser Thr Trp Gly Gln Val Gln Ala Ser Tyr Thr Phe Lys Ala Thr Val 
                 85                  90                  95
Asn Asp Ser Gly Glu Tyr Arg Cys Arg Met Ala His Thr Ser Leu Ser 
             100                105                110
Asp Pro Val His Leu Glu Val Ile Ser Asp Trp Leu Leu Leu Gln Thr 
         115                120                125
Pro Gln Leu Val Phe Glu Glu Gly Glu Thr Ile Thr Leu Arg Cys His 
     130                135                140
Ser Trp Lys Asn Lys Gln Leu Thr Lys Val Leu Leu Phe Gln Asn Gly 
 145                150                155                160
Lys Pro Val Arg Tyr Tyr Tyr Gln Ser Ser Asn Phe Ser Ile Pro Lys 
                 165                170                175
Ala Asn His Ser His Ser Gly Asn Tyr Tyr Cys Lys Ala Tyr Leu Gly 
             180                185                190
Arg Thr Met His Val Ser Lys Pro Val Thr Ile Thr Val Gln Gly Ser 
         195                200                205
Ala Thr Ala Ser Thr Ser Ser Leu Val Trp Phe His Ala Ala Phe Cys 
     210                215                220
Leu Val Met Cys Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Cys 
 225                230                235                240
Val Arg Arg Asn Leu Gln Thr Ser Gly Glu Asp Trp Arg Lys Ser Leu 
                 245                250                255
Ser Val Gly Lys Tyr Lys Ala Pro Gln Asp Lys 
             260                265



<210> 3630
<211> 634
<212> DNA
<213> Homo sapiens
<308> AV703731
<400> 3630

caggagaaa  aacactatg  taatttcat  gttacttga  gtctctttc  atctgaaga  60
ctgggttgt  tggagaatt  aacatagcc  agcaatatt  tcaattagt  atgtcatct  120
aaaaatgtt  acttttact  agttttatt  agaggatct  tgtattatt  gaaaaatga  180
gtatttctg  catggaaca  agaaagtgg  aactggtac  taatggggg  agcaaaatt  240
gctgggact  aaacggaca  gttttgttt  gtgaattct  cctaaatgt  tctctatcc  300
cagagaaac  agtattact  gaagatgtg  aagttcctg  ggtagccat  ccttgaagc  360
cagtgtttg  acataagta  atatcttga  tctaaatta  atccagatt  aactaatat  420
tattatttt  tatctttgt  gtattaaaa  gtttaaaaa  actaaaaat  aaacatttg  480
aagttggat  acaaaaaaa  aaaaaaaaa  ctcgagggg  ggcccggta  ccacttcgc  540
ctatagtga  tcgtattac  attcactgg  ccgccgttt  caacgtcgt  actggggct  600
cgtaataac  aagaggccc  caccggtcg  cttt  634



<210> 3631
<211> 317
<212> PRT
<213> Homo sapiens
<308> AAA35827
<400> 3631

Met Ala Met Glu Thr Gln Met Ser Gln Asn Val Cys Pro Arg Asn Leu 
  1               5                  10                  15
Trp Leu Leu Gln Pro Leu Thr Val Leu Leu Leu Leu Ala Ser Ala Asp 
             20                  25                  30
Ser Gln Ala Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro 
         35                  40                  45
Trp Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly 
     50                  55                  60
Ala Arg Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn 
 65                  70                  75                  80
Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn 
                 85                  90                  95
Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser 
             100                105                110
Asp Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr 
         115                120                125
Pro His Leu Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His 
     130                135                140
Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly 
 145                150                155                160
Lys Ser Gln Lys Phe Ser Arg Leu Asp Pro Thr Phe Ser Ile Pro Gln 
                 165                170                175
Ala Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly 
             180                185                190
Tyr Thr Leu Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val Pro 
         195                200                205
Ser Met Gly Ser Ser Ser Pro Met Gly Ile Ile Val Ala Val Val Ile 
     210                215                220
Ala Thr Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr 
 225                230                235                240
Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
                 245                250                255
Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
             260                265                270
Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
         275                280                285
Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
     290                295                300
Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
 305                310                315



<210> 3632
<211> 1341
<212> DNA
<213> Rattus norvegicus
<308> M32062
<400> 3632

ccagcaatt  catctccta  acctcatca  actctgacc  agttcttga  tgactttgg  60
gacccagat  tttcagaat  cacattctg  aagccaatg  ctactccca  cactgacaa  120
gttgctgct  tttgctttt  cagacaggc  gacgggaga  cttctgaag  ctgtggtga  180
acgtgatcc  ccatggatc  aggtgctca  ggacgacac  gtgacgctg  cgtgcgaag  240
gacccacaa  cctggaaac  cttctaccc  gtggttcca  aaccagagc  ccacctggg  300
ccaggtcca  gccagctac  cgtttaagg  cacagtcaa  gacagtgga  aataccggt  360
ccgaatggc  cacaccagc  tcagcgacc  catacatct  gaagtgatt  ctgactggc  420
gctgctcca  acccctcaa  tggtgtttg  ggaagggga  accatcaca  taaggtgcc  480
tagctggaa  aacaaacag  tgactaagg  cttgttgtt  cagaatgga  aacctgtga  540
gtattatta  caaagcagc  atttttcaa  ccccaaagc  aaccacagt  acagtggga  600
ctactactg  aaagcatat  taggaagga  aatgcatgt  tccaagcct  tcaccatca  660
tgtccaagg  tcagcaacc  cgtccacca  ctctctagt  tggttccat  ccgctttct  720
cctagtgat  tgcctcctg  ttgcagtgg  caccggcct  tatttctgt  tacggagaa  780
tcttcaaac  tcgggggag  actggagga  atccctgtc  gtcggaaag  acaaggctc  840
acaggacaa  tgacatccc  tcgtatggc  aaacagcgg  agcttcttt  cagccacac  900
gccgcttca  ctacagcct  cctttgaaa  caacttacc  ccaggctgg  tatttggtc  960
tgcaatcac  actgctagg  ggctgaggc  ggaggatca  caaaggctg  ccgggtttt  1020
gagaagaga  agtgcaagt  tatcctgga  aacccaata  gaccctggg  ttagatggc  1080
tatcaggaa  gagcaccca  tgctaagct  acagacaag  ccacagatt  atccctaag  1140
acacagggc  aagggggag  acaaattcc  gaaagttgt  ctctgacct  cacacgtcc  1200
ccatggcag  tgcacacaa  aaacaaatt  aaatgtaat  tatatattt  aaacaagag  1260
tggggaaag  ctgggggtt  gtggcacag  ttttatcca  gacacatga  gctctggat  1320
ttgacctcc  ataataaaa  g  1341



<210> 3633
<211> 267
<212> PRT
<213> Rattus norvegicus
<308> P27645
<400> 3633

Met Thr Leu Glu Thr Gln Met Phe Gln Asn Ala His Ser Gly Ser Gln 
  1               5                  10                  15
Trp Leu Leu Pro Pro Leu Thr Met Leu Leu Leu Phe Ala Phe Ala Asp 
             20                  25                  30
Arg Gln Thr Ala Asn Leu Pro Lys Ala Val Val Lys Arg Asp Pro Pro 
         35                  40                  45
Trp Ile Gln Val Leu Lys Glu Asp Thr Val Thr Leu Thr Cys Glu Gly 
     50                  55                  60
Thr His Asn Pro Gly Asn Ser Ser Thr Gln Trp Phe His Asn Gln Ser 
 65                  70                  75                  80
Ser Thr Trp Gly Gln Val Gln Ala Ser Tyr Thr Phe Lys Ala Thr Val 
                 85                  90                  95
Asn Asp Ser Gly Glu Tyr Arg Cys Arg Met Ala His Thr Ser Leu Ser 
             100                105                110
Asp Pro Val His Leu Glu Val Ile Ser Asp Trp Leu Leu Leu Gln Thr 
         115                120                125
Pro Gln Leu Val Phe Glu Glu Gly Glu Thr Ile Thr Leu Arg Cys His 
     130                135                140
Ser Trp Lys Asn Lys Gln Leu Thr Lys Val Leu Leu Phe Gln Asn Gly 
 145                150                155                160
Lys Pro Val Arg Tyr Tyr Tyr Gln Ser Ser Asn Phe Ser Ile Pro Lys 
                 165                170                175
Ala Asn His Ser His Ser Gly Asn Tyr Tyr Cys Lys Ala Tyr Leu Gly 
             180                185                190
Arg Thr Met His Val Ser Lys Pro Val Thr Ile Thr Val Gln Gly Ser 
         195                200                205
Ala Thr Ala Ser Thr Ser Ser Leu Val Trp Phe His Ala Ala Phe Cys 
     210                215                220
Leu Val Met Cys Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Cys 
 225                230                235                240
Val Arg Arg Asn Leu Gln Thr Ser Gly Glu Asp Trp Arg Lys Ser Leu 
                 245                250                255
Ser Val Gly Lys Tyr Lys Ala Pro Gln Asp Lys 
             260                265



<210> 3634
<211> 634
<212> DNA
<213> Homo sapiens
<308> AV703731
<400> 3634

caggagaaa  aacactatg  taatttcat  gttacttga  gtctctttc  atctgaaga  60
ctgggttgt  tggagaatt  aacatagcc  agcaatatt  tcaattagt  atgtcatct  120
aaaaatgtt  acttttact  agttttatt  agaggatct  tgtattatt  gaaaaatga  180
gtatttctg  catggaaca  agaaagtgg  aactggtac  taatggggg  agcaaaatt  240
gctgggact  aaacggaca  gttttgttt  gtgaattct  cctaaatgt  tctctatcc  300
cagagaaac  agtattact  gaagatgtg  aagttcctg  ggtagccat  ccttgaagc  360
cagtgtttg  acataagta  atatcttga  tctaaatta  atccagatt  aactaatat  420
tattatttt  tatctttgt  gtattaaaa  gtttaaaaa  actaaaaat  aaacatttg  480
aagttggat  acaaaaaaa  aaaaaaaaa  ctcgagggg  ggcccggta  ccacttcgc  540
ctatagtga  tcgtattac  attcactgg  ccgccgttt  caacgtcgt  actggggct  600
cgtaataac  aagaggccc  caccggtcg  cttt  634



<210> 3635
<211> 317
<212> PRT
<213> Homo sapiens
<308> AAA35827
<400> 3635

Met Ala Met Glu Thr Gln Met Ser Gln Asn Val Cys Pro Arg Asn Leu 
  1               5                  10                  15
Trp Leu Leu Gln Pro Leu Thr Val Leu Leu Leu Leu Ala Ser Ala Asp 
             20                  25                  30
Ser Gln Ala Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro 
         35                  40                  45
Trp Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly 
     50                  55                  60
Ala Arg Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn 
 65                  70                  75                  80
Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn 
                 85                  90                  95
Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser 
             100                105                110
Asp Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr 
         115                120                125
Pro His Leu Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His 
     130                135                140
Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly 
 145                150                155                160
Lys Ser Gln Lys Phe Ser Arg Leu Asp Pro Thr Phe Ser Ile Pro Gln 
                 165                170                175
Ala Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly 
             180                185                190
Tyr Thr Leu Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val Pro 
         195                200                205
Ser Met Gly Ser Ser Ser Pro Met Gly Ile Ile Val Ala Val Val Ile 
     210                215                220
Ala Thr Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr 
 225                230                235                240
Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
                 245                250                255
Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
             260                265                270
Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
         275                280                285
Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
     290                295                300
Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
 305                310                315



<210> 3636
<211> 1341
<212> DNA
<213> Rattus norvegicus
<308> M32062
<400> 3636

ccagcaatt  catctccta  acctcatca  actctgacc  agttcttga  tgactttgg  60
gacccagat  tttcagaat  cacattctg  aagccaatg  ctactccca  cactgacaa  120
gttgctgct  tttgctttt  cagacaggc  gacgggaga  cttctgaag  ctgtggtga  180
acgtgatcc  ccatggatc  aggtgctca  ggacgacac  gtgacgctg  cgtgcgaag  240
gacccacaa  cctggaaac  cttctaccc  gtggttcca  aaccagagc  ccacctggg  300
ccaggtcca  gccagctac  cgtttaagg  cacagtcaa  gacagtgga  aataccggt  360
ccgaatggc  cacaccagc  tcagcgacc  catacatct  gaagtgatt  ctgactggc  420
gctgctcca  acccctcaa  tggtgtttg  ggaagggga  accatcaca  taaggtgcc  480
tagctggaa  aacaaacag  tgactaagg  cttgttgtt  cagaatgga  aacctgtga  540
gtattatta  caaagcagc  atttttcaa  ccccaaagc  aaccacagt  acagtggga  600
ctactactg  aaagcatat  taggaagga  aatgcatgt  tccaagcct  tcaccatca  660
tgtccaagg  tcagcaacc  cgtccacca  ctctctagt  tggttccat  ccgctttct  720
cctagtgat  tgcctcctg  ttgcagtgg  caccggcct  tatttctgt  tacggagaa  780
tcttcaaac  tcgggggag  actggagga  atccctgtc  gtcggaaag  acaaggctc  840
acaggacaa  tgacatccc  tcgtatggc  aaacagcgg  agcttcttt  cagccacac  900
gccgcttca  ctacagcct  cctttgaaa  caacttacc  ccaggctgg  tatttggtc  960
tgcaatcac  actgctagg  ggctgaggc  ggaggatca  caaaggctg  ccgggtttt  1020
gagaagaga  agtgcaagt  tatcctgga  aacccaata  gaccctggg  ttagatggc  1080
tatcaggaa  gagcaccca  tgctaagct  acagacaag  ccacagatt  atccctaag  1140
acacagggc  aagggggag  acaaattcc  gaaagttgt  ctctgacct  cacacgtcc  1200
ccatggcag  tgcacacaa  aaacaaatt  aaatgtaat  tatatattt  aaacaagag  1260
tggggaaag  ctgggggtt  gtggcacag  ttttatcca  gacacatga  gctctggat  1320
ttgacctcc  ataataaaa  g  1341



<210> 3637
<211> 267
<212> PRT
<213> Rattus norvegicus
<308> P27645
<400> 3637

Met Thr Leu Glu Thr Gln Met Phe Gln Asn Ala His Ser Gly Ser Gln 
  1               5                  10                  15
Trp Leu Leu Pro Pro Leu Thr Met Leu Leu Leu Phe Ala Phe Ala Asp 
             20                  25                  30
Arg Gln Thr Ala Asn Leu Pro Lys Ala Val Val Lys Arg Asp Pro Pro 
         35                  40                  45
Trp Ile Gln Val Leu Lys Glu Asp Thr Val Thr Leu Thr Cys Glu Gly 
     50                  55                  60
Thr His Asn Pro Gly Asn Ser Ser Thr Gln Trp Phe His Asn Gln Ser 
 65                  70                  75                  80
Ser Thr Trp Gly Gln Val Gln Ala Ser Tyr Thr Phe Lys Ala Thr Val 
                 85                  90                  95
Asn Asp Ser Gly Glu Tyr Arg Cys Arg Met Ala His Thr Ser Leu Ser 
             100                105                110
Asp Pro Val His Leu Glu Val Ile Ser Asp Trp Leu Leu Leu Gln Thr 
         115                120                125
Pro Gln Leu Val Phe Glu Glu Gly Glu Thr Ile Thr Leu Arg Cys His 
     130                135                140
Ser Trp Lys Asn Lys Gln Leu Thr Lys Val Leu Leu Phe Gln Asn Gly 
 145                150                155                160
Lys Pro Val Arg Tyr Tyr Tyr Gln Ser Ser Asn Phe Ser Ile Pro Lys 
                 165                170                175
Ala Asn His Ser His Ser Gly Asn Tyr Tyr Cys Lys Ala Tyr Leu Gly 
             180                185                190
Arg Thr Met His Val Ser Lys Pro Val Thr Ile Thr Val Gln Gly Ser 
         195                200                205
Ala Thr Ala Ser Thr Ser Ser Leu Val Trp Phe His Ala Ala Phe Cys 
     210                215                220
Leu Val Met Cys Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Cys 
 225                230                235                240
Val Arg Arg Asn Leu Gln Thr Ser Gly Glu Asp Trp Arg Lys Ser Leu 
                 245                250                255
Ser Val Gly Lys Tyr Lys Ala Pro Gln Asp Lys 
             260                265



<210> 3638
<211> 634
<212> DNA
<213> Homo sapiens
<308> AV703731
<400> 3638

caggagaaa  aacactatg  taatttcat  gttacttga  gtctctttc  atctgaaga  60
ctgggttgt  tggagaatt  aacatagcc  agcaatatt  tcaattagt  atgtcatct  120
aaaaatgtt  acttttact  agttttatt  agaggatct  tgtattatt  gaaaaatga  180
gtatttctg  catggaaca  agaaagtgg  aactggtac  taatggggg  agcaaaatt  240
gctgggact  aaacggaca  gttttgttt  gtgaattct  cctaaatgt  tctctatcc  300
cagagaaac  agtattact  gaagatgtg  aagttcctg  ggtagccat  ccttgaagc  360
cagtgtttg  acataagta  atatcttga  tctaaatta  atccagatt  aactaatat  420
tattatttt  tatctttgt  gtattaaaa  gtttaaaaa  actaaaaat  aaacatttg  480
aagttggat  acaaaaaaa  aaaaaaaaa  ctcgagggg  ggcccggta  ccacttcgc  540
ctatagtga  tcgtattac  attcactgg  ccgccgttt  caacgtcgt  actggggct  600
cgtaataac  aagaggccc  caccggtcg  cttt  634



<210> 3639
<211> 317
<212> PRT
<213> Homo sapiens
<308> AAA35827
<400> 3639

Met Ala Met Glu Thr Gln Met Ser Gln Asn Val Cys Pro Arg Asn Leu 
  1               5                  10                  15
Trp Leu Leu Gln Pro Leu Thr Val Leu Leu Leu Leu Ala Ser Ala Asp 
             20                  25                  30
Ser Gln Ala Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro 
         35                  40                  45
Trp Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly 
     50                  55                  60
Ala Arg Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn 
 65                  70                  75                  80
Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn 
                 85                  90                  95
Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser 
             100                105                110
Asp Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr 
         115                120                125
Pro His Leu Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His 
     130                135                140
Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly 
 145                150                155                160
Lys Ser Gln Lys Phe Ser Arg Leu Asp Pro Thr Phe Ser Ile Pro Gln 
                 165                170                175
Ala Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly 
             180                185                190
Tyr Thr Leu Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val Pro 
         195                200                205
Ser Met Gly Ser Ser Ser Pro Met Gly Ile Ile Val Ala Val Val Ile 
     210                215                220
Ala Thr Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr 
 225                230                235                240
Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
                 245                250                255
Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
             260                265                270
Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
         275                280                285
Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
     290                295                300
Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
 305                310                315



<210> 3640
<211> 1603
<212> DNA
<213> Rattus norvegicus
<308> M32397
<400> 3640

cacctccta  agctgccac  agcagctct  ttcccccac  atgagagct  tccctctgc  60
cctcgtcgg  acagcaagc  tcacccttg  cttcttgct  ctgctatct  tccgcctgg  120
cccaggcca  gccaaggag  tgaagtttg  gacattggt  ttccggcat  gagaccgag  180
tcccatcga  acctttcct  atgacccca  taaggaatc  tcgtggcca  aaggatttg  240
ccaactcac  aagtggggc  tgggacagc  ctacgaact  ggaagttat  taaggagaa  300
atacgggag  ttcttgaac  actcctata  acatgacca  gtttatatc  gaagcacag  360
tgttgacag  actctgatg  gcgctatga  aaacctcgc  gccctgttt  cccctgagg  420
gatcagcat  tggaatccc  gactgctct  gcagcccat  ccagtgcac  ccgtgtctc  480
ctctgagga  cggttgcta  acctgcctt  cagggactg  cctcgcttt  aagaactca  540
gagtgagac  ttaaaatct  aggagttcc  gaagaggct  caaccatat  aaagcttca  600
agacacctt  ccatcgctg  cgggattcg  ggaccagga  ctttttgaa  tctggagta  660
gctttacga  cctttatat  gcgagagtg  tcacaattt  accttccgc  cctgggcca  720
agaggacgc  atgactaag  tgaaggagt  gtcagaatt  tctctgtta  ctctttatg  780
aattcacaa  cagaaagag  aatctagac  ccagggggg  gtcctggtc  atgaaattc  840
caagaacat  aagcttgca  ctcaaccac  gaaggccag  aagttgatc  tgtattctg  900
atatgacac  actgtgagt  gcctgcaga  ggcgctaga  ctttataat  gacttctac  960
tccctacgc  tcctgccac  taatggaat  gtaccagga  aatgggggg  ccttcgtgg  1020
gatgtacta  cggaatgag  cccagaacg  gccctaccc  ctcacgctg  cgggctgta  1080
ccacagctg  cctctggag  agtttgcag  gctactgga  cccgtgatc  cccaggact  1140
ggccacaga  tgtatgggc  caagcaacc  ccaagcgtc  ctgtaaaag  acaaccagt  1200
gccagtgta  tcaggaaaa  agttaggtc  aacttgtgg  tctgccggg  atccatgat  1260
agcacaaag  actctattg  tgaaggatt  gaagatttt  cttgagcgg  tgagtaaag  1320
tgccctggg  atgtctgat  taaaaacag  tttcagacg  agcctacca  gttagcgtg  1380
aagcatgaa  aagaagaca  ttatcccag  ctaatgggc  aaggacctg  ttcacctga  1440
aacaacgct  acctgttcc  ctgccttct  tcacgaggc  aaaagatga  acaggagga  1500
acctggagg  gttttccat  cccagccta  aacgatcag  ttttatatg  atgtcaaaa  1560
acgctgggt  gcagaactg  ataataaaa  cctcttggt  tcc  1603



<210> 3641
<211> 381
<212> PRT
<213> Rattus norvegicus
<308> P20646
<400> 3641

Met Arg Ala Val Pro Leu His Leu Val Gly Thr Ala Ser Leu Thr Leu 
  1               5                  10                  15
Gly Phe Leu Leu Leu Leu Ser Leu Arg Leu Asp Pro Gly Gln Ala Lys 
             20                  25                  30
Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Gly Pro 
         35                  40                  45
Ile Glu Thr Phe Pro Asn Asp Pro Ile Lys Glu Ser Ser Trp Pro Gln 
     50                  55                  60
Gly Phe Gly Gln Leu Thr Lys Trp Gly Met Gly Gln His Tyr Glu Leu 
 65                  70                  75                  80
Gly Ser Tyr Ile Arg Arg Arg Tyr Gly Arg Phe Leu Asn Asn Ser Tyr 
                 85                  90                  95
Lys His Asp Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr Leu 
             100                105                110
Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly Ile 
         115                120                125
Ser Ile Trp Asn Pro Arg Leu Leu Trp Gln Pro Ile Pro Val His Thr 
     130                135                140
Val Ser Leu Ser Glu Asp Arg Leu Leu Tyr Leu Pro Phe Arg Asp Cys 
 145                150                155                160
Pro Arg Phe Gln Glu Leu Lys Ser Glu Thr Leu Lys Ser Glu Glu Phe 
                 165                170                175
Leu Lys Arg Leu Gln Pro Tyr Lys Ser Phe Ile Asp Thr Leu Pro Ser 
             180                185                190
Leu Ser Gly Phe Glu Asp Gln Asp Leu Phe Glu Ile Trp Ser Arg Leu 
         195                200                205
Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Phe Arg Thr 
     210                215                220
Trp Ala Thr Glu Asp Ala Met Thr Lys Leu Lys Glu Leu Ser Glu Leu 
 225                230                235                240
Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser Arg 
                 245                250                255
Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Lys Asn Met Lys Leu 
             260                265                270
Ala Thr Gln Pro Gln Lys Ala Arg Lys Leu Ile Met Tyr Ser Ala Tyr 
         275                280                285
Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Glu Leu Tyr Asn Gly 
     290                295                300
Leu Leu Pro Pro Tyr Ala Ser Cys His Ile Met Glu Leu Tyr Gln Asp 
 305                310                315                320
Asn Gly Gly Thr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln Asn 
                 325                330                335
Glu Pro Tyr Pro Leu Thr Leu Pro Gly Cys Thr His Ser Cys Pro Leu 
             340                345                350
Glu Lys Phe Ala Glu Leu Leu Asp Pro Val Ile Pro Gln Asp Trp Ala 
         355                360                365
Thr Glu Cys Met Gly Thr Ser Asn His Gln Ala Ser Leu 
     370                375                380



<210> 3642
<211> 3061
<212> DNA
<213> Homo sapiens
<308> M34840
<400> 3642

cggctctcc  caacatgag  gctgcaccc  tcctcctgg  cagggcagc  agccttagc  60
ttggcttct  gtttctgct  tttttctgg  tagaccgaa  tgtactagc  aaggagttg  120
agtttgtga  tttggtgtt  cggcatgga  accgaagtc  cattgacac  tttcccact  180
accccataa  ggaatcctc  tggccacaa  gatttggcc  actcaccca  ctgggcatg  240
agcagcatt  tgaacttgg  gagtatata  gaaagagat  tagaaaatt  ttgaatgag  300
cctataaac  tgaacaggt  tatattcga  gcacagacg  tgaccggac  ttgatgagt  360
ctatgacaa  cctggcagc  ctgtttccc  cagaaggtg  cagcatctg  aatcctatc  420
tactctggc  gcccatccc  gtgcacaca  ttcctcttt  tgaagatca  ttgctatac  480
tgcctttca  gaactgccc  cgttttcaa  aacttgaga  tgagacttt  aaatcagag  540
aattccaga  gaggctgca  ccttataag  attttatag  taccttggg  aaactttca  600
gattacatg  ccaggacct  tttggaatt  ggagtaaag  ctacgaccc  ttatattgt  660
agagtgttc  caatttcac  ttaccctcc  gggccactg  ggacaccat  actaagttg  720
gagaattgt  agaattgtc  ctcctgtcc  tctatggaa  tcacaagca  aaagagaaa  780
ctaggctcc  agggggtgt  ctggtcaat  aaatcctca  tcacatgaa  agagcaact  840
agataccaa  ctacaaaaa  cttatcatg  attctgcgc  tgacactac  gtgagtggc  900
tacagatgg  gctagatgt  tacaacgga  tccttcctc  ctatgcttc  tgccacttg  960
cggaattgt  ctttgagaa  ggggagtac  ttgtggaga  gtactatcg  aatgagacg  1020
agcacgagc  gtatcccct  atgctacct  gctgcagcc  tagctgtcc  ctggagagg  1080
ttgctgagc  ggttggccc  gtgatccct  aagactggt  cacggagtg  atgaccaca  1140
acagccatc  aggtactga  gacagtaca  attagtgtg  acagagatc  ctgtagaaa  1200
agtagctgc  ctttctcag  gcagatgat  ctttgagaa  atactttgg  cattacccc  1260
cagctttga  gaaaatggg  tttggatga  tattttatg  tttagggac  cccaacctc  1320
ggcaattcc  acctcttca  ctgaccctg  ccccacttg  cataaaact  agctaagtt  1380
tgttttgtt  ttcagcgtt  atgtaaagg  gcagcagtg  caaaatata  tcagagata  1440
agcttaggt  aaagttcat  gagttccca  gaactatat  actggccac  caggatctt  1500
tgtatttaa  gattctgag  ttttgcttg  gcaggatta  ataagtctg  tctttaaat  1560
tctgaaatg  aacagattt  aaaaaaaat  cccacaatc  agggtggga  caaggaagg  1620
aagatgtga  taggctgat  gggaaaaaa  caatttacc  atcagttcc  gccttctct  1680
aaggagagg  aaagaaagg  gatacagtg  agacatctg  aaagttttc  ccactggaa  1740
actgctact  tctgttttt  tatttctgt  aaaatatat  aggctacag  actaaaaat  1800
aaaacctct  tgtgtccct  ggtcctgga  catttatgt  ccttttaaa  aaacaaaaa  1860
caaacttta  agaaagatt  gatgtatgt  atacatata  cagctcttg  agtatatat  1920
tcatagcaa  taagtcatc  gatgagaac  agctatttg  gcacaacac  tcaggaaag  1980
gagcaccac  tgatggagt  tctccagaa  ctccagtga  aagagatgt  gactctaaa  2040
ttgatttaa  gccaggcat  gtggtttac  cctataatc  cagcatttt  ggactccga  2100
gtgggcaga  cacttgagc  caggagctc  agatcagcc  gggcaacat  gtgaaacct  2160
gtctctaca  aaaatacaa  aacttagat  ggcatggtg  tgtgtgcct  tagtccact  2220
cttgtgggg  taaggcagg  ggatcactt  agccccgga  gtcgaggct  cagtgaccc  2280
agagtgcac  actgtactc  agccagggc  agagagcga  accctgtct  aataaataa  2340
taaataaat  aataaataa  taaataaaa  caaagttga  taagaaagg  agtataggc  2400
aggcacagt  gctcacacc  gtaatcctt  cattttgga  ggctgaggc  ggaggatca  2460
tttaggcct  gtgtgttca  gaccagcct  gtcaacata  tgagacact  tctctacca  2520
aaaaaggaa  gaagggaca  atatcaaac  gaaacaaaa  tagaaatgt  attatgtta  2580
gttctaagt  cctccaagt  caaaactta  tggaatgtt  agagtgtgg  tacgaaata  2640
gttaggagg  caaaaggaa  gtgtaagtc  ttaatgccg  tatcttcag  aaacctaag  2700
aaacttaca  gtcctgctg  aactgccca  tctgcaaga  gaaatcatg  tatagcttt  2760
catgtggca  atctacatg  ctagagaac  ctgtgctct  ttaccatta  ggataaaga  2820
gagatggtt  ctagagatg  tttctactg  ctgccagaa  ctagagcaa  gccatcccc  2880
ctcctggtt  gtcacagaa  gactgacaa  gacatcgat  gatatgctt  tttgtgtta  2940
ttccctccc  agtaaatgt  tgtccttgg  tccattttc  atgcttgta  ctgtcttct  3000
gcagtgagc  aaatgtaaa  tagtgaata  agtcattat  aggaagttc  aaaaaaaaa  3060
a  3061



<210> 3643
<211> 386
<212> PRT
<213> Homo sapiens
<308> P15309
<400> 3643

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
  1               5                  10                  15
Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
             20                  25                  30
Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
         35                  40                  45
Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
     50                  55                  60
Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
 65                  70                  75                  80
Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                 85                  90                  95
Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
             100                105                110
Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
         115                120                125
Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
     130                135                140
Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
 145                150                155                160
Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                 165                170                175
Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
             180                185                190
Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
         195                200                205
Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
     210                215                220
Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
 225                230                235                240
Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                 245                250                255
Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
             260                265                270
Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
         275                280                285
His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
     290                295                300
Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
 305                310                315                320
Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                 325                330                335
His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
             340                345                350
Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
         355                360                365
Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 
     370                375                380
Thr Asp 
 385



<210> 3644
<211> 1603
<212> DNA
<213> Rattus norvegicus
<308> M32397
<400> 3644

cacctccta  agctgccac  agcagctct  ttcccccac  atgagagct  tccctctgc  60
cctcgtcgg  acagcaagc  tcacccttg  cttcttgct  ctgctatct  tccgcctgg  120
cccaggcca  gccaaggag  tgaagtttg  gacattggt  ttccggcat  gagaccgag  180
tcccatcga  acctttcct  atgacccca  taaggaatc  tcgtggcca  aaggatttg  240
ccaactcac  aagtggggc  tgggacagc  ctacgaact  ggaagttat  taaggagaa  300
atacgggag  ttcttgaac  actcctata  acatgacca  gtttatatc  gaagcacag  360
tgttgacag  actctgatg  gcgctatga  aaacctcgc  gccctgttt  cccctgagg  420
gatcagcat  tggaatccc  gactgctct  gcagcccat  ccagtgcac  ccgtgtctc  480
ctctgagga  cggttgcta  acctgcctt  cagggactg  cctcgcttt  aagaactca  540
gagtgagac  ttaaaatct  aggagttcc  gaagaggct  caaccatat  aaagcttca  600
agacacctt  ccatcgctg  cgggattcg  ggaccagga  ctttttgaa  tctggagta  660
gctttacga  cctttatat  gcgagagtg  tcacaattt  accttccgc  cctgggcca  720
agaggacgc  atgactaag  tgaaggagt  gtcagaatt  tctctgtta  ctctttatg  780
aattcacaa  cagaaagag  aatctagac  ccagggggg  gtcctggtc  atgaaattc  840
caagaacat  aagcttgca  ctcaaccac  gaaggccag  aagttgatc  tgtattctg  900
atatgacac  actgtgagt  gcctgcaga  ggcgctaga  ctttataat  gacttctac  960
tccctacgc  tcctgccac  taatggaat  gtaccagga  aatgggggg  ccttcgtgg  1020
gatgtacta  cggaatgag  cccagaacg  gccctaccc  ctcacgctg  cgggctgta  1080
ccacagctg  cctctggag  agtttgcag  gctactgga  cccgtgatc  cccaggact  1140
ggccacaga  tgtatgggc  caagcaacc  ccaagcgtc  ctgtaaaag  acaaccagt  1200
gccagtgta  tcaggaaaa  agttaggtc  aacttgtgg  tctgccggg  atccatgat  1260
agcacaaag  actctattg  tgaaggatt  gaagatttt  cttgagcgg  tgagtaaag  1320
tgccctggg  atgtctgat  taaaaacag  tttcagacg  agcctacca  gttagcgtg  1380
aagcatgaa  aagaagaca  ttatcccag  ctaatgggc  aaggacctg  ttcacctga  1440
aacaacgct  acctgttcc  ctgccttct  tcacgaggc  aaaagatga  acaggagga  1500
acctggagg  gttttccat  cccagccta  aacgatcag  ttttatatg  atgtcaaaa  1560
acgctgggt  gcagaactg  ataataaaa  cctcttggt  tcc  1603



<210> 3645
<211> 381
<212> PRT
<213> Rattus norvegicus
<308> P20646
<400> 3645

Met Arg Ala Val Pro Leu His Leu Val Gly Thr Ala Ser Leu Thr Leu 
  1               5                  10                  15
Gly Phe Leu Leu Leu Leu Ser Leu Arg Leu Asp Pro Gly Gln Ala Lys 
             20                  25                  30
Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Gly Pro 
         35                  40                  45
Ile Glu Thr Phe Pro Asn Asp Pro Ile Lys Glu Ser Ser Trp Pro Gln 
     50                  55                  60
Gly Phe Gly Gln Leu Thr Lys Trp Gly Met Gly Gln His Tyr Glu Leu 
 65                  70                  75                  80
Gly Ser Tyr Ile Arg Arg Arg Tyr Gly Arg Phe Leu Asn Asn Ser Tyr 
                 85                  90                  95
Lys His Asp Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr Leu 
             100                105                110
Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly Ile 
         115                120                125
Ser Ile Trp Asn Pro Arg Leu Leu Trp Gln Pro Ile Pro Val His Thr 
     130                135                140
Val Ser Leu Ser Glu Asp Arg Leu Leu Tyr Leu Pro Phe Arg Asp Cys 
 145                150                155                160
Pro Arg Phe Gln Glu Leu Lys Ser Glu Thr Leu Lys Ser Glu Glu Phe 
                 165                170                175
Leu Lys Arg Leu Gln Pro Tyr Lys Ser Phe Ile Asp Thr Leu Pro Ser 
             180                185                190
Leu Ser Gly Phe Glu Asp Gln Asp Leu Phe Glu Ile Trp Ser Arg Leu 
         195                200                205
Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Phe Arg Thr 
     210                215                220
Trp Ala Thr Glu Asp Ala Met Thr Lys Leu Lys Glu Leu Ser Glu Leu 
 225                230                235                240
Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser Arg 
                 245                250                255
Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Lys Asn Met Lys Leu 
             260                265                270
Ala Thr Gln Pro Gln Lys Ala Arg Lys Leu Ile Met Tyr Ser Ala Tyr 
         275                280                285
Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Glu Leu Tyr Asn Gly 
     290                295                300
Leu Leu Pro Pro Tyr Ala Ser Cys His Ile Met Glu Leu Tyr Gln Asp 
 305                310                315                320
Asn Gly Gly Thr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln Asn 
                 325                330                335
Glu Pro Tyr Pro Leu Thr Leu Pro Gly Cys Thr His Ser Cys Pro Leu 
             340                345                350
Glu Lys Phe Ala Glu Leu Leu Asp Pro Val Ile Pro Gln Asp Trp Ala 
         355                360                365
Thr Glu Cys Met Gly Thr Ser Asn His Gln Ala Ser Leu 
     370                375                380



<210> 3646
<211> 3061
<212> DNA
<213> Homo sapiens
<308> M34840
<400> 3646

cggctctcc  caacatgag  gctgcaccc  tcctcctgg  cagggcagc  agccttagc  60
ttggcttct  gtttctgct  tttttctgg  tagaccgaa  tgtactagc  aaggagttg  120
agtttgtga  tttggtgtt  cggcatgga  accgaagtc  cattgacac  tttcccact  180
accccataa  ggaatcctc  tggccacaa  gatttggcc  actcaccca  ctgggcatg  240
agcagcatt  tgaacttgg  gagtatata  gaaagagat  tagaaaatt  ttgaatgag  300
cctataaac  tgaacaggt  tatattcga  gcacagacg  tgaccggac  ttgatgagt  360
ctatgacaa  cctggcagc  ctgtttccc  cagaaggtg  cagcatctg  aatcctatc  420
tactctggc  gcccatccc  gtgcacaca  ttcctcttt  tgaagatca  ttgctatac  480
tgcctttca  gaactgccc  cgttttcaa  aacttgaga  tgagacttt  aaatcagag  540
aattccaga  gaggctgca  ccttataag  attttatag  taccttggg  aaactttca  600
gattacatg  ccaggacct  tttggaatt  ggagtaaag  ctacgaccc  ttatattgt  660
agagtgttc  caatttcac  ttaccctcc  gggccactg  ggacaccat  actaagttg  720
gagaattgt  agaattgtc  ctcctgtcc  tctatggaa  tcacaagca  aaagagaaa  780
ctaggctcc  agggggtgt  ctggtcaat  aaatcctca  tcacatgaa  agagcaact  840
agataccaa  ctacaaaaa  cttatcatg  attctgcgc  tgacactac  gtgagtggc  900
tacagatgg  gctagatgt  tacaacgga  tccttcctc  ctatgcttc  tgccacttg  960
cggaattgt  ctttgagaa  ggggagtac  ttgtggaga  gtactatcg  aatgagacg  1020
agcacgagc  gtatcccct  atgctacct  gctgcagcc  tagctgtcc  ctggagagg  1080
ttgctgagc  ggttggccc  gtgatccct  aagactggt  cacggagtg  atgaccaca  1140
acagccatc  aggtactga  gacagtaca  attagtgtg  acagagatc  ctgtagaaa  1200
agtagctgc  ctttctcag  gcagatgat  ctttgagaa  atactttgg  cattacccc  1260
cagctttga  gaaaatggg  tttggatga  tattttatg  tttagggac  cccaacctc  1320
ggcaattcc  acctcttca  ctgaccctg  ccccacttg  cataaaact  agctaagtt  1380
tgttttgtt  ttcagcgtt  atgtaaagg  gcagcagtg  caaaatata  tcagagata  1440
agcttaggt  aaagttcat  gagttccca  gaactatat  actggccac  caggatctt  1500
tgtatttaa  gattctgag  ttttgcttg  gcaggatta  ataagtctg  tctttaaat  1560
tctgaaatg  aacagattt  aaaaaaaat  cccacaatc  agggtggga  caaggaagg  1620
aagatgtga  taggctgat  gggaaaaaa  caatttacc  atcagttcc  gccttctct  1680
aaggagagg  aaagaaagg  gatacagtg  agacatctg  aaagttttc  ccactggaa  1740
actgctact  tctgttttt  tatttctgt  aaaatatat  aggctacag  actaaaaat  1800
aaaacctct  tgtgtccct  ggtcctgga  catttatgt  ccttttaaa  aaacaaaaa  1860
caaacttta  agaaagatt  gatgtatgt  atacatata  cagctcttg  agtatatat  1920
tcatagcaa  taagtcatc  gatgagaac  agctatttg  gcacaacac  tcaggaaag  1980
gagcaccac  tgatggagt  tctccagaa  ctccagtga  aagagatgt  gactctaaa  2040
ttgatttaa  gccaggcat  gtggtttac  cctataatc  cagcatttt  ggactccga  2100
gtgggcaga  cacttgagc  caggagctc  agatcagcc  gggcaacat  gtgaaacct  2160
gtctctaca  aaaatacaa  aacttagat  ggcatggtg  tgtgtgcct  tagtccact  2220
cttgtgggg  taaggcagg  ggatcactt  agccccgga  gtcgaggct  cagtgaccc  2280
agagtgcac  actgtactc  agccagggc  agagagcga  accctgtct  aataaataa  2340
taaataaat  aataaataa  taaataaaa  caaagttga  taagaaagg  agtataggc  2400
aggcacagt  gctcacacc  gtaatcctt  cattttgga  ggctgaggc  ggaggatca  2460
tttaggcct  gtgtgttca  gaccagcct  gtcaacata  tgagacact  tctctacca  2520
aaaaaggaa  gaagggaca  atatcaaac  gaaacaaaa  tagaaatgt  attatgtta  2580
gttctaagt  cctccaagt  caaaactta  tggaatgtt  agagtgtgg  tacgaaata  2640
gttaggagg  caaaaggaa  gtgtaagtc  ttaatgccg  tatcttcag  aaacctaag  2700
aaacttaca  gtcctgctg  aactgccca  tctgcaaga  gaaatcatg  tatagcttt  2760
catgtggca  atctacatg  ctagagaac  ctgtgctct  ttaccatta  ggataaaga  2820
gagatggtt  ctagagatg  tttctactg  ctgccagaa  ctagagcaa  gccatcccc  2880
ctcctggtt  gtcacagaa  gactgacaa  gacatcgat  gatatgctt  tttgtgtta  2940
ttccctccc  agtaaatgt  tgtccttgg  tccattttc  atgcttgta  ctgtcttct  3000
gcagtgagc  aaatgtaaa  tagtgaata  agtcattat  aggaagttc  aaaaaaaaa  3060
a  3061



<210> 3647
<211> 386
<212> PRT
<213> Homo sapiens
<308> P15309
<400> 3647

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
  1               5                  10                  15
Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
             20                  25                  30
Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
         35                  40                  45
Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
     50                  55                  60
Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
 65                  70                  75                  80
Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                 85                  90                  95
Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
             100                105                110
Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
         115                120                125
Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
     130                135                140
Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
 145                150                155                160
Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                 165                170                175
Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
             180                185                190
Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
         195                200                205
Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
     210                215                220
Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
 225                230                235                240
Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                 245                250                255
Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
             260                265                270
Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
         275                280                285
His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
     290                295                300
Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
 305                310                315                320
Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                 325                330                335
His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
             340                345                350
Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
         355                360                365
Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 
     370                375                380
Thr Asp 
 385



<210> 3648
<211> 3201
<212> DNA
<213> Rattus norvegicus
<308> M32867
<400> 3648

ccgggtaag  aaataagct  ccctatttt  ctttcttct  ctcttacaa  tggaaccag  60
catttcccc  aactaccac  atggaggtg  caatggtga  tgccgagag  tcagggtgc  120
acagccaca  gccttatgg  tatgctgcc  aggccaggg  tcgagagag  gagagactt  180
ctcactcca  ggcagctgc  gctctggct  ttgcagctg  cacggctgc  gtggaaggc  240
ctggaggtt  tggtggagg  ccccaccat  atcatcaga  acgtggggc  tactcctcc  300
atgatcctc  aggaagccg  ggtagtcgg  ggaggaggc  acagcgaac  gagaagaag  360
aactccacc  caggcagag  agttttcct  attgctcag  cctgatgcc  agtggctct  420
aagagaaga  ccttaggga  ctgagcgag  aggaggaag  cgaggagga  gaagaggag  480
aggaagagg  gggaaggtt  tactatagt  aagaggacc  tggggatgg  tgttcctac  540
ctgacctac  gccacagga  gatgggggt  gcggcggct  cagttcagt  cgctacagt  600
actgttgtg  acgcgtggt  ataaatgtg  ctggtctac  cttcgaaac  caaatgaaa  660
ctttggctc  gtttccaga  actctgttg  gagaccctg  gaagaggac  cagtacttc  720
accctttgc  caatgagta  ttttttgat  ggaaccgtc  cagctttga  gccattttg  780
attattacc  gtcaggagg  cgcctgaag  ggccagtca  tgtcccctt  gatatcttc  840
ctgaggagg  gaagttcta  cagttggga  aggaagccc  gctcaagtt  cgtgaggat  900
agggctttg  gagagaaga  gaggacagg  ctctgccag  aaatgaatt  aaaaaacag  960
tttggcttc  ctttgaata  cccgagagt  ccagccctg  cagggcgat  gccatcgta  1020
ctgtcctgg  catcttaat  tctattgtc  tattttgcc  ggaaacctt  cctgagttc  1080
gggatgata  ggacctcat  atggccctc  gcgcaggtg  acacagcag  ttattgaat  1140
acacctcgg  accccacct  gagaactca  ggcacacaa  attcaatga  cctttcttc  1200
ttgtggaga  agtatgtat  gtgtggttt  cctttgagt  tgtggttcg  tgctttgct  1260
gtcccagtc  agcactctt  ttcaaaaac  tcatgaaca  cattgatat  gtctccatt  1320
tgccttact  catcactct  ggcaccgat  tggcccagc  gcagggggg  ggcaacggc  1380
agcagcagc  ggctatgtc  tttgccatc  tcaggatca  ccgtctggt  cgagtgttc  1440
ggatcttca  gctctccag  cactccaag  gcctgcaga  cctgggcca  accctaaga  1500
ccagcatgc  tgaactggg  cttcttatc  ttttcctct  catcggggt  atcctcttt  1560
ccagcgctg  gtattttgc  gaggcagat  aacctacca  ccatttcca  agcattcca  1620
atgcgtttt  gtgggctgt  gtaaccatg  caactgtgg  ctacgggga  atgaagccc  1680
tcacagtgg  aggaaagat  gtggggtcc  tgtgtgcca  tgcgggtgt  ttaaccatt  1740
ctttgcccg  gccggtgat  gtgtctaac  ttaactatt  ctaccacag  gagactgaa  1800
acgaagaac  gacccagct  acccaaaac  cagtcagtt  cccatacct  ccttctaat  1860
tgctcaaga  atttcggag  tctacttct  cttccctgg  ggacaagtc  gagtatcta  1920
agatggaag  aggggtcaa  gagtcttta  gtggaaagg  agagaagtg  cagggaaag  1980
gggatgaca  cgagacaga  aaaaacaac  gttctaatg  aaaggctgt  gagactgat  2040
tgtgaatct  tttccccac  tgccgtgcc  ccgcccagc  ccgaatata  tcatacata  2100
agaatgcag  tatgaaaat  agatatgca  tgcatacag  aatacactg  ttaatggcg  2160
tacatggca  aattgtggc  aaacgtgta  tgcatatca  ataagtgat  catcttgga  2220
aagagggag  cattaaaaa  agcagatct  tctttatat  ttttaatag  atgcaagaa  2280
tttgcacat  atgggaaaa  gttaatagt  aaggtggtc  cgaggagag  gagtgtgtg  2340
gagagagtg  gagagtgtg  ggccatggg  gtgtaagta  attgtcaac  ttgttggga  2400
ttgtgccgt  atgggaaaa  ttggcattc  gaagtattt  ctatgtaag  actaatgaa  2460
ttgagcagt  ttttaccag  gttttaata  catctccta  gtctttgga  tctgtagtt  2520
ttttctaga  attgtaaga  ttactgtgt  gaaaaaaga  aaagtaaat  atttaatag  2580
atataggtc  caatttaat  ttggattta  ttaaagttt  tttttaact  gaaattaac  2640
tttgaaaag  ctgcagggc  ttagaaatt  attatattt  gttattaat  ttgggagat  2700
tactagcaa  tgcctaatg  tctggagga  atgtaacaa  ttttgttca  aggtcttaa  2760
actggaatt  ttttttctt  tgcactact  tctatgctg  agcccgaga  agacttcat  2820
ctgtgaatg  ttactaacg  accaatcag  tcaatgaca  tcattggaa  aatggtttc  2880
tcgtctcat  tattgttct  ttcattttg  gagactaat  agcacacag  taacagcac  2940
cgattcctg  tttaaaatc  gaacaaccg  tctacaaag  gactacgaa  taacgttca  3000
cagccgaat  tttcaaaat  ggtttgtta  aatgatgct  cagaaacca  actattttc  3060
atactcttc  gccttttaa  tccagaata  tttaaccaa  gttattgca  gcacagaaa  3120
aattccggc  ttttgttgc  tatttaata  aaagatctt  agccataat  gctgtagct  3180
ctgggcgcc  tatttctcc  a  3201



<210> 3649
<211> 655
<212> PRT
<213> Rattus norvegicus
<308> P15385
<400> 3649

Met Glu Val Ala Met Val Ser Ala Glu Ser Ser Gly Cys Asn Ser His 
  1               5                  10                  15
Met Pro Tyr Gly Tyr Ala Ala Gln Ala Arg Ala Arg Glu Arg Glu Arg 
             20                  25                  30
Leu Ala His Ser Arg Ala Ala Ala Ala Ala Ala Val Ala Ala Ala Thr 
         35                  40                  45
Ala Ala Val Glu Gly Thr Gly Gly Ser Gly Gly Gly Pro His His His 
     50                  55                  60
His Gln Thr Arg Gly Ala Tyr Ser Ser His Asp Pro Gln Gly Ser Arg 
 65                  70                  75                  80
Gly Ser Arg Glu Glu Glu Ala Thr Arg Thr Glu Lys Lys Lys Lys Leu 
                 85                  90                  95
His His Arg Gln Ser Ser Phe Pro His Cys Ser Asp Leu Met Pro Ser 
             100                105                110
Gly Ser Glu Glu Lys Ile Leu Arg Glu Leu Ser Glu Glu Glu Glu Asp 
         115                120                125
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Arg Phe Tyr Tyr Ser 
     130                135                140
Glu Glu Asp His Gly Asp Gly Cys Ser Tyr Thr Asp Leu Leu Pro Gln 
 145                150                155                160
Asp Asp Gly Gly Gly Gly Gly Tyr Ser Ser Val Arg Tyr Ser Asp Cys 
                 165                170                175
Cys Glu Arg Val Val Ile Asn Val Ser Gly Leu Arg Phe Glu Thr Gln 
             180                185                190
Met Lys Thr Leu Ala Gln Phe Pro Glu Thr Leu Leu Gly Asp Pro Glu 
         195                200                205
Lys Arg Thr Gln Tyr Phe Asp Pro Leu Arg Asn Glu Tyr Phe Phe Asp 
     210                215                220
Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr Gln Ser Gly 
 225                230                235                240
Gly Arg Leu Lys Arg Pro Val Asn Val Pro Phe Asp Ile Phe Thr Glu 
                 245                250                255
Glu Val Lys Phe Tyr Gln Leu Gly Glu Glu Ala Leu Leu Lys Phe Arg 
             260                265                270
Glu Asp Glu Gly Phe Val Arg Glu Glu Glu Asp Arg Ala Leu Pro Glu 
         275                280                285
Asn Glu Phe Lys Lys Gln Ile Trp Leu Leu Phe Glu Tyr Pro Glu Ser 
     290                295                300
Ser Ser Pro Ala Arg Gly Ile Ala Ile Val Ser Val Leu Val Ile Leu 
 305                310                315                320
Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Phe Arg Asp 
                 325                330                335
Asp Arg Asp Leu Ile Met Ala Leu Ser Ala Gly Gly His Ser Arg Leu 
             340                345                350
Leu Asn Asp Thr Ser Ala Pro His Leu Glu Asn Ser Gly His Thr Ile 
         355                360                365
Phe Asn Asp Pro Phe Phe Ile Val Glu Thr Val Cys Ile Val Trp Phe 
     370                375                380
Ser Phe Glu Phe Val Val Arg Cys Phe Ala Cys Pro Ser Gln Ala Leu 
 385                390                395                400
Phe Phe Lys Asn Ile Met Asn Ile Ile Asp Ile Val Ser Ile Leu Pro 
                 405                410                415
Tyr Phe Ile Thr Leu Gly Thr Asp Leu Ala Gln Gln Gln Gly Gly Gly 
             420                425                430
Asn Gly Gln Gln Gln Gln Ala Met Ser Phe Ala Ile Leu Arg Ile Ile 
         435                440                445
Arg Leu Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys 
     450                455                460
Gly Leu Gln Ile Leu Gly His Thr Leu Arg Ala Ser Met Arg Glu Leu 
 465                470                475                480
Gly Leu Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe Ser Ser 
                 485                490                495
Ala Val Tyr Phe Ala Glu Ala Asp Glu Pro Thr Thr His Phe Gln Ser 
             500                505                510
Ile Pro Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly 
         515                520                525
Tyr Gly Asp Met Lys Pro Ile Thr Val Gly Gly Lys Ile Val Gly Ser 
     530                535                540
Leu Cys Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val 
 545                550                555                560
Ile Val Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Glu Asn Glu 
                 565                570                575
Glu Gln Thr Gln Leu Thr Gln Asn Ala Val Ser Cys Pro Tyr Leu Pro 
             580                585                590
Ser Asn Leu Leu Lys Lys Phe Arg Ser Ser Thr Ser Ser Ser Leu Gly 
         595                600                605
Asp Lys Ser Glu Tyr Leu Glu Met Glu Glu Gly Val Lys Glu Ser Leu 
     610                615                620
Cys Gly Lys Glu Glu Lys Cys Gln Gly Lys Gly Asp Asp Ser Glu Thr 
 625                630                635                640
Asp Lys Asn Asn Cys Ser Asn Ala Lys Ala Val Glu Thr Asp Val 
                 645                650                655



<210> 3650
<211> 1962
<212> DNA
<213> Homo sapiens
<308> L02751
<400> 3650

atggaggtt  caatggtga  tgcggagag  tcagggtgc  acagtcaca  gccttatgg  60
tatgctgcc  aggcccggg  ccgggagcg  gagaggctt  ctcactcca  ggcagctgc  120
gcagctgct  ttgcagcgg  cacagctgc  gtcgaaggt  gcgggggtt  tggtggggg  180
tcccaccac  accaccagt  acgcggggc  tgtacctcc  atgaccctc  gagcagccg  240
ggtagtcgg  ggaggaggc  acagcggtc  gagaagaag  aagcccact  ccggcagag  300
agcttccct  attgctctg  cctgatgcc  agtggctct  aggagaaga  cctgaggga  360
ctgagtgag  aggaggaag  tgaggagga  gaggaagag  aggaagagg  gggaaggtt  420
tactatagt  aagatgacc  tggtgatga  tgttcctac  cggatctgc  gcctcagga  480
gagggcggt  gcggctaca  ttcagtccg  tacagtgac  gttgtgaac  tgtggtgat  540
aatgtgtca  gcctacgct  tgagaccca  atgaaaact  tggcccagt  tccagagac  600
ttgttggga  accctgaaa  gaggactca  tactttgac  ctttgcgca  tgagtattt  660
tttgacagg  accgcccca  ctttgatgc  atcttgtat  attatcaat  aggaggccg  720
ctgaagagg  cagtcaatg  cccctttga  atcttcact  aggaggtga  gttctatca  780
ttgggggag  aggccctgt  gaagtttcg  gaggacgag  gctttgtga  agaagagga  840
gacagggcc  tccccgaga  tgaatttaa  aagcagatt  ggctcctct  tgaatatcc  900
gagagctcc  gtcctgcaa  gggcatagc  attgtgtcc  tcctggtca  cttaatctc  960
attgtcatc  tttgcctgg  aaccttgcc  gagtttagg  acgacaggg  tctcgtcat  1020
gcactgagt  ctggcgggc  tggtgggtt  ttgaatgat  cttcagcac  ccatctgga  1080
aactcaggc  acacaatat  caatgaccc  ttcttcatc  tggaaacag  ctgtattgt  1140
tggttttcc  ttgagtttg  ggttcgctg  tttgcttgt  ccagccaag  actcttctt  1200
aaaaacatc  tgaacatca  tgacattgt  tccattttg  cttacttca  cacactggg  1260
actgacctg  cccagcaac  ggggggtgg  aatggtcag  agcagcagg  catgtcctt  1320
gccatcctc  gaatcattc  tctggtccg  gtattccgg  tcttcaaac  ctccaggca  1380
tccaaaggc  tgcagatcc  gggccacac  ctcagagcc  gcatgcggg  actgggcct  1440
ctgatcttc  tcctcttca  tggggtcat  ctcttttct  gtgctgtgt  ttttgcaga  1500
gcggatgaa  ctactaccc  tttccaaag  atcccagat  cattttggt  ggctgtggt  1560
accatgaca  ctgtgggct  tggggacat  aagcccatc  ctgtagggg  caagattgt  1620
gggtccctg  gtgccattg  gggtgtctt  accattgct  tgccagtgc  agtgattgt  1680
tctaacttt  actatttct  ccacagaga  actgaaaat  aggaacaga  acagctaac  1740
cagaatgca  tcagttgtc  atacctccc  tctaatttg  tcaagaaat  tcggagctc  1800
acttcttct  ccctggggg  caagtcaga  tatctagag  tggaagaag  agttaagga  1860
tctctgtgt  caaaggagg  gaagtgtca  ggaaagggg  atgacagtg  gacagataa  1920
aacaactgt  ctaatgcaa  ggctgtgga  actgatgtg  ga  1962



<210> 3651
<211> 653
<212> PRT
<213> Homo sapiens
<308> P22459
<400> 3651

Met Glu Val Ala Met Val Ser Ala Glu Ser Ser Gly Cys Asn Ser His 
  1               5                  10                  15
Met Pro Tyr Gly Tyr Ala Ala Gln Ala Arg Ala Arg Glu Arg Glu Arg 
             20                  25                  30
Leu Ala His Ser Arg Arg Ala Ala Ala Arg Ala Val Ala Ala Ala Thr 
         35                  40                  45
Ala Ala Val Glu Gly Ser Gly Gly Ser Gly Gly Gly Ser His His His 
     50                  55                  60
His Gln Ser Arg Gly Ala Cys Thr Ser His Asp Pro Gln Ser Ser Arg 
 65                  70                  75                  80
Gly Ser Arg Glu Glu Glu Ala Thr Arg Ser Glu Lys Lys Lys Ala His 
                 85                  90                  95
Tyr Arg Gln Ser Ser Phe Pro His Cys Ser Asp Leu Met Pro Ser Gly 
             100                105                110
Ser Glu Glu Lys Ile Leu Arg Glu Leu Ser Glu Glu Glu Glu Asp Glu 
         115                120                125
Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Arg Phe Tyr Tyr Ser Glu 
     130                135                140
Asp Asp His Gly Asp Glu Cys Ser Tyr Thr Asp Leu Leu Pro Gln Asp 
 145                150                155                160
Glu Gly Gly Gly Gly Tyr Ser Ser Val Arg Tyr Ser Asp Cys Cys Glu 
                 165                170                175
Arg Val Val Ile Asn Val Ser Gly Leu Arg Phe Glu Thr Gln Met Lys 
             180                185                190
Thr Leu Ala Gln Phe Pro Glu Thr Leu Leu Gly Asp Pro Glu Lys Arg 
         195                200                205
Thr Gln Tyr Phe Asp Pro Leu Arg Asn Glu Tyr Phe Phe Asp Arg Asn 
     210                215                220
Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr Gln Ser Gly Gly Arg 
 225                230                235                240
Leu Lys Arg Pro Val Asn Val Pro Phe Asp Ile Phe Thr Glu Glu Val 
                 245                250                255
Lys Phe Tyr Gln Leu Gly Glu Glu Ala Leu Leu Lys Phe Arg Glu Asp 
             260                265                270
Glu Gly Phe Val Arg Glu Glu Glu Asp Arg Ala Leu Pro Glu Asn Glu 
         275                280                285
Phe Lys Lys Gln Ile Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Asp 
     290                295                300
Pro Ala Arg Gly Ile Ala Ile Val Ser Val Leu Val Ile Leu Ile Ser 
 305                310                315                320
Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Phe Arg Asp Asp Arg 
                 325                330                335
Asp Leu Val Met Ala Leu Ser Ala Gly Gly His Gly Gly Leu Leu Asn 
             340                345                350
Asp Thr Ser Ala Pro His Leu Glu Asn Ser Gly His Thr Ile Phe Asn 
         355                360                365
Asp Pro Phe Phe Ile Val Glu Thr Val Cys Ile Val Trp Phe Ser Phe 
     370                375                380
Glu Phe Val Val Arg Cys Phe Ala Cys Pro Ser Gln Ala Leu Phe Phe 
 385                390                395                400
Lys Asn Ile Met Asn Ile Ile Asp Ile Val Ser Ile Leu Pro Tyr Phe 
                 405                410                415
Ile Thr Leu Gly Thr Asp Leu Ala Gln Gln Gln Gly Gly Gly Asn Gly 
             420                425                430
Gln Gln Gln Gln Ala Met Ser Phe Ala Ile Leu Arg Ile Ile Arg Leu 
         435                440                445
Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu 
     450                455                460
Gln Ile Leu Gly His Thr Leu Arg Ala Ser Met Arg Glu Leu Gly Leu 
 465                470                475                480
Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe Ser Ser Ala Val 
                 485                490                495
Tyr Phe Ala Glu Ala Asp Glu Pro Thr Thr His Phe Gln Ser Ile Pro 
             500                505                510
Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr Gly 
         515                520                525
Asp Met Lys Pro Ile Thr Val Gly Gly Lys Ile Val Gly Val Leu Cys 
     530                535                540
Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile Val 
 545                550                555                560
Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Glu Asn Glu Glu Gln 
                 565                570                575
Thr Gln Leu Thr Gln Asn Ala Val Ser Cys Pro Tyr Leu Pro Ser Asn 
             580                585                590
Leu Leu Lys Lys Phe Arg Ser Ser Thr Ser Ser Ser Leu Gly Asp Lys 
         595                600                605
Ser Glu Tyr Leu Glu Met Glu Glu Gly Val Lys Glu Ser Leu Cys Ala 
     610                615                620
Lys Glu Glu Lys Cys Gln Ala Lys Gly Asp Asp Ser Glu Thr Asp Lys 
 625                630                635                640
Asn Asn Cys Ser Asn Ala Lys Ala Val Glu Thr Asp Val 
                 645                650



<210> 3652
<211> 1994
<212> DNA
<213> Rattus norvegicus
<308> M33648
<400> 3652

atctctccc  ggggctgtg  actgctggc  ttctgttga  accttagag  tgcagcggc  60
tttggctcc  gcaaggcgg  tcctgcaag  gaagagagt  atgcaggaa  cttcgctct  120
acccgctca  ctgctcccc  cagcccagc  gaggttttc  acaatccct  ctgctcccc  180
ggccaaaac  gatacatgg  caaaagatg  gggcatcct  gccctggag  tctactttc  240
agcccaata  gtggaccaa  ctgacctgg  gaagttcaa  aatgtggaa  cagggaagt  300
cacagtggg  ttgggccag  cccgtatgg  cttctgttc  gtccaggag  acatcaact  360
cttgtgcct  acagtggtg  agaggctga  ggaacgcac  aagctgcca  gggatgccg  420
aggccgcct  gaagtgggc  cggaaacca  cattgacaa  tccaaggct  tcaagacag  480
gctcatgga  ctcttccag  attcaggca  cactgacat  gagggcata  ataccacca  540
cgcctgcta  ggtggcact  cctccctct  caacgctgc  aactggatg  agtccagct  600
ctgggatgg  cgctatgcc  tggtggtct  tggtgatat  gcagtctac  caagtggta  660
cccccgccc  acaggtggt  ccggggctg  ggcaatgct  attgggccc  aggccccgc  720
agtcctgga  caagggctg  ggggaaccc  catggagaa  gcctatgac  tctacaaac  780
aaacttggc  tcagagtat  cactggtgg  tgggaagct  tctatccag  gctacctgc  840
ggccttgga  cgatgctat  cagcttacc  caggaaaat  cagaatcag  ggaagcaag  900
tggaaacaa  cagcctttc  ccctcgatg  cgtgcaata  atgatcttc  acacaccct  960
ttgcaagat  gtccagaaa  ccctagctc  gctgatgtt  aatgacttc  tgtcatcta  1020
cagtgacaa  cagaacaac  tatacaagg  tctagaggc  ttcaagggt  taaagctgg  1080
agaaaccta  accaacaag  atgttgaca  ggctctgct  aaggcctcc  tggacatgt  1140
caacaagaa  accaaggcc  ccctttacc  ctccacaaa  aatgggaac  tgtacacct  1200
gtccctcta  gggtgcctg  cctcacttc  ctcccacca  tctgcccaa  aattggccg  1260
ctccaggat  ggagccttc  cctacggct  aggcttagc  gcaagtttc  tctcatttc  1320
agtgtccaa  gacgcttcc  caggttccc  tctggagaa  ctggtgtct  gtgtgtcag  1380
tctgcccaa  cgtctagac  cccggagac  catgtcccc  gaggaattc  cagaaataa  1440
gaatcagag  gagcaattt  accacaagg  gaacttctc  ccccctggt  acacaagca  1500
cctcttccc  ggcacttgg  accttgaac  agtggatga  atgcaccgc  gaaaatatg  1560
ccggcgtcc  gtctaagga  accaatcca  acaaccatt  cccggggaa  gaatgtgag  1620
agagccgtt  cccaaacgg  ttccactta  aattccacc  acagcagtg  acggtgaat  1680
gacacagcg  ccccatagg  tctgctccg  ggtgaaggg  ctccctctg  ggatcctgg  1740
tgaccctcc  tgaagcagt  agcaccaca  gttctgctg  ggaccagag  ccccctgtg  1800
agagggaga  agaaagggg  gccgctgac  tgcagggat  cagaccttc  ccacagcct  1860
gcagccgcc  gtttgttgc  gcttattat  agactgtgg  ctatcatag  tcatgctcg  1920
ttcttaaag  ttcccgaga  tttctaaaa  tttgtatct  aacttttaa  atggcgatt  1980
aaaggagag  agga  1994



<210> 3653
<211> 508
<212> PRT
<213> Rattus norvegicus
<308> P22791
<400> 3653

Met Gln Arg Leu Leu Ala Pro Ala Arg Arg Val Leu Gln Val Lys Arg 
  1               5                  10                  15
Val Met Gln Glu Ser Ser Leu Ser Pro Ala His Leu Leu Pro Ala Ala 
             20                  25                  30
Gln Gln Arg Phe Ser Thr Ile Pro Pro Ala Pro Leu Ala Lys Thr Asp 
         35                  40                  45
Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro 
     50                  55                  60
Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Phe Asn Asn Val Glu 
 65                  70                  75                  80
Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys 
                 85                  90                  95
Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg 
             100                105                110
Leu Met Glu Arg Thr Lys Leu Pro Trp Asp Ala Val Gly Arg Leu Glu 
         115                120                125
Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val 
     130                135                140
Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile 
 145                150                155                160
Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala 
                 165                170                175
Ala Asn Trp Met Glu Ser Ser Tyr Trp Asp Gly Arg Tyr Ala Leu Val 
             180                185                190
Val Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn Pro Arg Pro Thr 
         195                200                205
Gly Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro Lys Ala Pro Leu 
     210                215                220
Val Leu Glu Gln Gly Leu Arg Gly Thr His Met Glu Asn Ala Tyr Asp 
 225                230                235                240
Phe Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Leu Val Asp Gly Lys 
                 245                250                255
Leu Ser Ile Gln Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Ala Ala 
             260                265                270
Tyr Arg Arg Lys Ile Gln Asn Gln Trp Lys Gln Ala Gly Asn Asn Gln 
         275                280                285
Pro Phe Thr Leu Asp Asp Val Gln Tyr Met Ile Phe His Thr Pro Phe 
     290                295                300
Cys Lys Met Val Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe 
 305                310                315                320
Leu Ser Ser Ser Ser Asp Lys Gln Asn Asn Leu Tyr Lys Gly Leu Glu 
                 325                330                335
Ala Phe Lys Gly Leu Lys Leu Glu Glu Thr Tyr Thr Asn Lys Asp Val 
             340                345                350
Asp Lys Ala Leu Leu Lys Ala Ser Leu Asp Met Phe Asn Lys Lys Thr 
         355                360                365
Lys Ala Ser Leu Tyr Leu Ser Thr Asn Asn Gly Asn Met Tyr Thr Ser 
     370                375                380
Ser Leu Tyr Gly Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln 
 385                390                395                400
Glu Leu Ala Gly Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu 
                 405                410                415
Ala Ala Ser Phe Phe Ser Phe Arg Val Ser Lys Asp Ala Ser Pro Gly 
             420                425                430
Ser Pro Leu Glu Lys Leu Val Ser Ser Val Ser Asp Leu Pro Lys Arg 
         435                440                445
Leu Asp Ser Arg Arg Arg Met Ser Pro Glu Glu Phe Thr Glu Ile Met 
     450                455                460
Asn Gln Arg Glu Gln Phe Tyr His Lys Val Asn Phe Ser Pro Pro Gly 
 465                470                475                480
Asp Thr Ser Asn Leu Phe Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp 
                 485                490                495
Glu Met His Arg Arg Lys Tyr Ala Arg Arg Pro Val 
             500                505



<210> 3654
<211> 2058
<212> DNA
<213> Homo sapiens
<308> X83618
<400> 3654

cggtttctg  tgggtttct  aactgctgg  tttctgctt  ctcctctgg  gatgcagcg  60
ctgttgact  cagtgaagc  cattctgca  ctgacaaga  cggtgcagg  aacctccct  120
acacctgct  gcctgctcc  agtagccca  caaaggttt  ctacagcct  tgctgtccc  180
ctggccaaa  cagatactt  gccaaagga  gtgggcatc  tggccctgg  ggtctactt  240
ccagcccaa  atgtggacc  aactgacct  gagaagtat  acaatgtgg  agcaggaaa  300
tatacagtg  gcttgggcc  gacccgtat  ggcttctgc  cagtccaag  ggacatcaa  360
tccctgtgc  tgacggtgg  gcaacggct  atggagcgc  tacagctcc  atgggactc  420
gtgggcagg  tggaagtag  cactgagac  atcattgac  agtccaaag  tgtcaaaac  480
gtgctcatg  aactcttcc  ggattcagg  aatactgat  ttgagggca  agataccac  540
aatgcctgc  acggtggta  tgcctccct  ttcaatgct  ccaactgga  ggagtccag  600
tcctgggat  gtcgttatg  catggtggt  tgtggagac  ttgccgtct  tcccagtgg  660
aatgctcgt  ccacaggtg  ggccggagc  gtggctatg  tgattggcc  aaaggcccc  720
ctggccctg  agcgagggc  gaggggaac  catatggag  atgtgtatg  cttctacaa  780
ccaaatttg  cctcggagt  cccaatagt  gatgggaag  tttccatcc  gtgctactt  840
cgggccttg  atcgatgtt  cacatcata  cgtaaaaaa  tccagaatc  gtggaagca  900
gctggcagc  atcgaccct  cacccttga  gatttacag  atatgatct  tcatacacc  960
ttttgcaag  tggtccaga  gtctctggc  cgcctgatg  tcaatgact  cctgtcagc  1020
agcagtgac  cacaaacca  cttatataa  gggctggag  ctttcgggg  gctaaagct  1080
gaagacacc  acaccaaca  ggacctgga  aaagcactt  taaaggcct  tcaggacat  1140
ttcgacaag  aaaccaagg  ttcccttta  ctctccact  acaatggga  catgtacac  1200
tcatccctg  acgggtgcc  ggcctcgct  ctgtcccac  actctgccc  agaactggc  1260
ggctccagg  ttggtgcct  ctcttatgg  tctggttta  cagcaagtt  cttttcatt  1320
cgagtatcc  aggatgctg  tccaggctc  cccctggac  agttggtgt  cagcacatc  1380
gacctgcca  aacgcctag  ctcccgaaa  tgtgtgtct  ctgaggagt  cacagaaat  1440
atgaaccaa  gagagcaat  ctaccataa  gtgaatttc  ccccacctg  tgacacaaa  1500
agccttttc  caggtactt  gtacctgga  cgagtggac  agcagcatc  ccgaaagta  1560
gcccggcgt  ccgtctaaa  gtgttctgc  gatccatgg  aagcttcct  ggaaacgta  1620
gctagcaga  cttctcccc  tgaatcata  ttttaagat  ccactctta  ctggtaaat  1680
aatttgaat  gacatagta  ccccataag  atcagccct  tagagtgag  agccatctc  1740
agcgggccc  tcattcctc  ccatgctgc  atcactgtc  tgggcttat  gtgcctatg  1800
actaggggt  ctttgtgaa  gagcaagat  gagcaatgg  gagaagacc  cttcctgaa  1860
cactggact  cagaaatgt  catgcagat  agctgttgc  ttcaagatc  agataaact  1920
tcctgtcat  tgttagaac  ttattatta  taatattgt  aaacttctg  gctgttcct  1980
tgaatctcc  aattttgta  cttgttcta  gctaatata  agcaattaa  aagagagaa  2040
gagaaaaaa  aaaaaaaa  2058



<210> 3655
<211> 508
<212> PRT
<213> Homo sapiens
<308> P54868
<400> 3655

Met Gln Arg Leu Leu Thr Pro Val Lys Arg Ile Leu Gln Leu Thr Arg 
  1               5                  10                  15
Ala Val Gln Glu Thr Ser Leu Thr Pro Ala Arg Leu Leu Pro Val Ala 
             20                  25                  30
His Gln Arg Phe Ser Thr Ala Ser Ala Val Pro Leu Ala Lys Thr Asp 
         35                  40                  45
Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro 
     50                  55                  60
Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Tyr Asn Asn Val Glu 
 65                  70                  75                  80
Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys 
                 85                  90                  95
Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg 
             100                105                110
Leu Met Glu Arg Ile Gln Leu Pro Trp Asp Ser Val Gly Arg Leu Glu 
         115                120                125
Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val 
     130                135                140
Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile 
 145                150                155                160
Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala 
                 165                170                175
Ala Asn Trp Met Glu Ser Ser Ser Trp Asp Gly Arg Tyr Ala Met Val 
             180                185                190
Val Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn Ala Arg Pro Thr 
         195                200                205
Gly Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro Lys Ala Pro Leu 
     210                215                220
Ala Leu Glu Arg Gly Leu Arg Gly Thr His Met Glu Asn Val Tyr Asp 
 225                230                235                240
Phe Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Ile Val Asp Gly Lys 
                 245                250                255
Leu Ser Ile Gln Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Thr Ser 
             260                265                270
Tyr Arg Lys Lys Ile Gln Asn Gln Trp Lys Gln Ala Gly Ser Asp Arg 
         275                280                285
Pro Phe Thr Leu Asp Asp Leu Gln Tyr Met Ile Phe His Thr Pro Phe 
     290                295                300
Cys Lys Met Val Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe 
 305                310                315                320
Leu Ser Ala Ser Ser Asp Thr Gln Thr Ser Leu Tyr Lys Gly Leu Glu 
                 325                330                335
Ala Phe Gly Gly Leu Lys Leu Glu Asp Thr Tyr Thr Asn Lys Asp Leu 
             340                345                350
Asp Lys Ala Leu Leu Lys Ala Ser Gln Asp Met Phe Asp Lys Lys Thr 
         355                360                365
Lys Ala Ser Leu Tyr Leu Ser Thr His Asn Gly Asn Met Tyr Thr Ser 
     370                375                380
Ser Leu Tyr Gly Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln 
 385                390                395                400
Glu Leu Ala Gly Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu 
                 405                410                415
Ala Ala Ser Phe Phe Ser Phe Arg Val Ser Gln Asp Ala Ala Pro Gly 
             420                425                430
Ser Pro Leu Asp Lys Leu Val Ser Ser Thr Ser Asp Leu Pro Lys Arg 
         435                440                445
Leu Ala Ser Arg Lys Cys Val Ser Pro Glu Glu Phe Thr Glu Ile Met 
     450                455                460
Asn Gln Arg Glu Gln Phe Tyr His Lys Val Asn Phe Ser Pro Pro Gly 
 465                470                475                480
Asp Thr Asn Ser Leu Phe Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp 
                 485                490                495
Glu Gln His Arg Arg Lys Tyr Ala Arg Arg Pro Val 
             500                505



<210> 3656
<211> 1994
<212> DNA
<213> Rattus norvegicus
<308> M33648
<400> 3656

atctctccc  ggggctgtg  actgctggc  ttctgttga  accttagag  tgcagcggc  60
tttggctcc  gcaaggcgg  tcctgcaag  gaagagagt  atgcaggaa  cttcgctct  120
acccgctca  ctgctcccc  cagcccagc  gaggttttc  acaatccct  ctgctcccc  180
ggccaaaac  gatacatgg  caaaagatg  gggcatcct  gccctggag  tctactttc  240
agcccaata  gtggaccaa  ctgacctgg  gaagttcaa  aatgtggaa  cagggaagt  300
cacagtggg  ttgggccag  cccgtatgg  cttctgttc  gtccaggag  acatcaact  360
cttgtgcct  acagtggtg  agaggctga  ggaacgcac  aagctgcca  gggatgccg  420
aggccgcct  gaagtgggc  cggaaacca  cattgacaa  tccaaggct  tcaagacag  480
gctcatgga  ctcttccag  attcaggca  cactgacat  gagggcata  ataccacca  540
cgcctgcta  ggtggcact  cctccctct  caacgctgc  aactggatg  agtccagct  600
ctgggatgg  cgctatgcc  tggtggtct  tggtgatat  gcagtctac  caagtggta  660
cccccgccc  acaggtggt  ccggggctg  ggcaatgct  attgggccc  aggccccgc  720
agtcctgga  caagggctg  ggggaaccc  catggagaa  gcctatgac  tctacaaac  780
aaacttggc  tcagagtat  cactggtgg  tgggaagct  tctatccag  gctacctgc  840
ggccttgga  cgatgctat  cagcttacc  caggaaaat  cagaatcag  ggaagcaag  900
tggaaacaa  cagcctttc  ccctcgatg  cgtgcaata  atgatcttc  acacaccct  960
ttgcaagat  gtccagaaa  ccctagctc  gctgatgtt  aatgacttc  tgtcatcta  1020
cagtgacaa  cagaacaac  tatacaagg  tctagaggc  ttcaagggt  taaagctgg  1080
agaaaccta  accaacaag  atgttgaca  ggctctgct  aaggcctcc  tggacatgt  1140
caacaagaa  accaaggcc  ccctttacc  ctccacaaa  aatgggaac  tgtacacct  1200
gtccctcta  gggtgcctg  cctcacttc  ctcccacca  tctgcccaa  aattggccg  1260
ctccaggat  ggagccttc  cctacggct  aggcttagc  gcaagtttc  tctcatttc  1320
agtgtccaa  gacgcttcc  caggttccc  tctggagaa  ctggtgtct  gtgtgtcag  1380
tctgcccaa  cgtctagac  cccggagac  catgtcccc  gaggaattc  cagaaataa  1440
gaatcagag  gagcaattt  accacaagg  gaacttctc  ccccctggt  acacaagca  1500
cctcttccc  ggcacttgg  accttgaac  agtggatga  atgcaccgc  gaaaatatg  1560
ccggcgtcc  gtctaagga  accaatcca  acaaccatt  cccggggaa  gaatgtgag  1620
agagccgtt  cccaaacgg  ttccactta  aattccacc  acagcagtg  acggtgaat  1680
gacacagcg  ccccatagg  tctgctccg  ggtgaaggg  ctccctctg  ggatcctgg  1740
tgaccctcc  tgaagcagt  agcaccaca  gttctgctg  ggaccagag  ccccctgtg  1800
agagggaga  agaaagggg  gccgctgac  tgcagggat  cagaccttc  ccacagcct  1860
gcagccgcc  gtttgttgc  gcttattat  agactgtgg  ctatcatag  tcatgctcg  1920
ttcttaaag  ttcccgaga  tttctaaaa  tttgtatct  aacttttaa  atggcgatt  1980
aaaggagag  agga  1994



<210> 3657
<211> 508
<212> PRT
<213> Rattus norvegicus
<308> P22791
<400> 3657

Met Gln Arg Leu Leu Ala Pro Ala Arg Arg Val Leu Gln Val Lys Arg 
  1               5                  10                  15
Val Met Gln Glu Ser Ser Leu Ser Pro Ala His Leu Leu Pro Ala Ala 
             20                  25                  30
Gln Gln Arg Phe Ser Thr Ile Pro Pro Ala Pro Leu Ala Lys Thr Asp 
         35                  40                  45
Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro 
     50                  55                  60
Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Phe Asn Asn Val Glu 
 65                  70                  75                  80
Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys 
                 85                  90                  95
Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg 
             100                105                110
Leu Met Glu Arg Thr Lys Leu Pro Trp Asp Ala Val Gly Arg Leu Glu 
         115                120                125
Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val 
     130                135                140
Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile 
 145                150                155                160
Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala 
                 165                170                175
Ala Asn Trp Met Glu Ser Ser Tyr Trp Asp Gly Arg Tyr Ala Leu Val 
             180                185                190
Val Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn Pro Arg Pro Thr 
         195                200                205
Gly Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro Lys Ala Pro Leu 
     210                215                220
Val Leu Glu Gln Gly Leu Arg Gly Thr His Met Glu Asn Ala Tyr Asp 
 225                230                235                240
Phe Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Leu Val Asp Gly Lys 
                 245                250                255
Leu Ser Ile Gln Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Ala Ala 
             260                265                270
Tyr Arg Arg Lys Ile Gln Asn Gln Trp Lys Gln Ala Gly Asn Asn Gln 
         275                280                285
Pro Phe Thr Leu Asp Asp Val Gln Tyr Met Ile Phe His Thr Pro Phe 
     290                295                300
Cys Lys Met Val Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe 
 305                310                315                320
Leu Ser Ser Ser Ser Asp Lys Gln Asn Asn Leu Tyr Lys Gly Leu Glu 
                 325                330                335
Ala Phe Lys Gly Leu Lys Leu Glu Glu Thr Tyr Thr Asn Lys Asp Val 
             340                345                350
Asp Lys Ala Leu Leu Lys Ala Ser Leu Asp Met Phe Asn Lys Lys Thr 
         355                360                365
Lys Ala Ser Leu Tyr Leu Ser Thr Asn Asn Gly Asn Met Tyr Thr Ser 
     370                375                380
Ser Leu Tyr Gly Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln 
 385                390                395                400
Glu Leu Ala Gly Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu 
                 405                410                415
Ala Ala Ser Phe Phe Ser Phe Arg Val Ser Lys Asp Ala Ser Pro Gly 
             420                425                430
Ser Pro Leu Glu Lys Leu Val Ser Ser Val Ser Asp Leu Pro Lys Arg 
         435                440                445
Leu Asp Ser Arg Arg Arg Met Ser Pro Glu Glu Phe Thr Glu Ile Met 
     450                455                460
Asn Gln Arg Glu Gln Phe Tyr His Lys Val Asn Phe Ser Pro Pro Gly 
 465                470                475                480
Asp Thr Ser Asn Leu Phe Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp 
                 485                490                495
Glu Met His Arg Arg Lys Tyr Ala Arg Arg Pro Val 
             500                505



<210> 3658
<211> 2058
<212> DNA
<213> Homo sapiens
<308> X83618
<400> 3658

cggtttctg  tgggtttct  aactgctgg  tttctgctt  ctcctctgg  gatgcagcg  60
ctgttgact  cagtgaagc  cattctgca  ctgacaaga  cggtgcagg  aacctccct  120
acacctgct  gcctgctcc  agtagccca  caaaggttt  ctacagcct  tgctgtccc  180
ctggccaaa  cagatactt  gccaaagga  gtgggcatc  tggccctgg  ggtctactt  240
ccagcccaa  atgtggacc  aactgacct  gagaagtat  acaatgtgg  agcaggaaa  300
tatacagtg  gcttgggcc  gacccgtat  ggcttctgc  cagtccaag  ggacatcaa  360
tccctgtgc  tgacggtgg  gcaacggct  atggagcgc  tacagctcc  atgggactc  420
gtgggcagg  tggaagtag  cactgagac  atcattgac  agtccaaag  tgtcaaaac  480
gtgctcatg  aactcttcc  ggattcagg  aatactgat  ttgagggca  agataccac  540
aatgcctgc  acggtggta  tgcctccct  ttcaatgct  ccaactgga  ggagtccag  600
tcctgggat  gtcgttatg  catggtggt  tgtggagac  ttgccgtct  tcccagtgg  660
aatgctcgt  ccacaggtg  ggccggagc  gtggctatg  tgattggcc  aaaggcccc  720
ctggccctg  agcgagggc  gaggggaac  catatggag  atgtgtatg  cttctacaa  780
ccaaatttg  cctcggagt  cccaatagt  gatgggaag  tttccatcc  gtgctactt  840
cgggccttg  atcgatgtt  cacatcata  cgtaaaaaa  tccagaatc  gtggaagca  900
gctggcagc  atcgaccct  cacccttga  gatttacag  atatgatct  tcatacacc  960
ttttgcaag  tggtccaga  gtctctggc  cgcctgatg  tcaatgact  cctgtcagc  1020
agcagtgac  cacaaacca  cttatataa  gggctggag  ctttcgggg  gctaaagct  1080
gaagacacc  acaccaaca  ggacctgga  aaagcactt  taaaggcct  tcaggacat  1140
ttcgacaag  aaaccaagg  ttcccttta  ctctccact  acaatggga  catgtacac  1200
tcatccctg  acgggtgcc  ggcctcgct  ctgtcccac  actctgccc  agaactggc  1260
ggctccagg  ttggtgcct  ctcttatgg  tctggttta  cagcaagtt  cttttcatt  1320
cgagtatcc  aggatgctg  tccaggctc  cccctggac  agttggtgt  cagcacatc  1380
gacctgcca  aacgcctag  ctcccgaaa  tgtgtgtct  ctgaggagt  cacagaaat  1440
atgaaccaa  gagagcaat  ctaccataa  gtgaatttc  ccccacctg  tgacacaaa  1500
agccttttc  caggtactt  gtacctgga  cgagtggac  agcagcatc  ccgaaagta  1560
gcccggcgt  ccgtctaaa  gtgttctgc  gatccatgg  aagcttcct  ggaaacgta  1620
gctagcaga  cttctcccc  tgaatcata  ttttaagat  ccactctta  ctggtaaat  1680
aatttgaat  gacatagta  ccccataag  atcagccct  tagagtgag  agccatctc  1740
agcgggccc  tcattcctc  ccatgctgc  atcactgtc  tgggcttat  gtgcctatg  1800
actaggggt  ctttgtgaa  gagcaagat  gagcaatgg  gagaagacc  cttcctgaa  1860
cactggact  cagaaatgt  catgcagat  agctgttgc  ttcaagatc  agataaact  1920
tcctgtcat  tgttagaac  ttattatta  taatattgt  aaacttctg  gctgttcct  1980
tgaatctcc  aattttgta  cttgttcta  gctaatata  agcaattaa  aagagagaa  2040
gagaaaaaa  aaaaaaaa  2058



<210> 3659
<211> 508
<212> PRT
<213> Homo sapiens
<308> P54868
<400> 3659

Met Gln Arg Leu Leu Thr Pro Val Lys Arg Ile Leu Gln Leu Thr Arg 
  1               5                  10                  15
Ala Val Gln Glu Thr Ser Leu Thr Pro Ala Arg Leu Leu Pro Val Ala 
             20                  25                  30
His Gln Arg Phe Ser Thr Ala Ser Ala Val Pro Leu Ala Lys Thr Asp 
         35                  40                  45
Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro 
     50                  55                  60
Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Tyr Asn Asn Val Glu 
 65                  70                  75                  80
Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys 
                 85                  90                  95
Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg 
             100                105                110
Leu Met Glu Arg Ile Gln Leu Pro Trp Asp Ser Val Gly Arg Leu Glu 
         115                120                125
Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val 
     130                135                140
Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile 
 145                150                155                160
Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala 
                 165                170                175
Ala Asn Trp Met Glu Ser Ser Ser Trp Asp Gly Arg Tyr Ala Met Val 
             180                185                190
Val Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn Ala Arg Pro Thr 
         195                200                205
Gly Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro Lys Ala Pro Leu 
     210                215                220
Ala Leu Glu Arg Gly Leu Arg Gly Thr His Met Glu Asn Val Tyr Asp 
 225                230                235                240
Phe Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Ile Val Asp Gly Lys 
                 245                250                255
Leu Ser Ile Gln Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Thr Ser 
             260                265                270
Tyr Arg Lys Lys Ile Gln Asn Gln Trp Lys Gln Ala Gly Ser Asp Arg 
         275                280                285
Pro Phe Thr Leu Asp Asp Leu Gln Tyr Met Ile Phe His Thr Pro Phe 
     290                295                300
Cys Lys Met Val Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe 
 305                310                315                320
Leu Ser Ala Ser Ser Asp Thr Gln Thr Ser Leu Tyr Lys Gly Leu Glu 
                 325                330                335
Ala Phe Gly Gly Leu Lys Leu Glu Asp Thr Tyr Thr Asn Lys Asp Leu 
             340                345                350
Asp Lys Ala Leu Leu Lys Ala Ser Gln Asp Met Phe Asp Lys Lys Thr 
         355                360                365
Lys Ala Ser Leu Tyr Leu Ser Thr His Asn Gly Asn Met Tyr Thr Ser 
     370                375                380
Ser Leu Tyr Gly Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln 
 385                390                395                400
Glu Leu Ala Gly Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu 
                 405                410                415
Ala Ala Ser Phe Phe Ser Phe Arg Val Ser Gln Asp Ala Ala Pro Gly 
             420                425                430
Ser Pro Leu Asp Lys Leu Val Ser Ser Thr Ser Asp Leu Pro Lys Arg 
         435                440                445
Leu Ala Ser Arg Lys Cys Val Ser Pro Glu Glu Phe Thr Glu Ile Met 
     450                455                460
Asn Gln Arg Glu Gln Phe Tyr His Lys Val Asn Phe Ser Pro Pro Gly 
 465                470                475                480
Asp Thr Asn Ser Leu Phe Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp 
                 485                490                495
Glu Gln His Arg Arg Lys Tyr Ala Arg Arg Pro Val 
             500                505



<210> 3660
<211> 3477
<212> DNA
<213> Rattus norvegicus
<308> M34176
<400> 3660

cggggctgt  ctctctgac  gccgccgcc  ccccgcccc  tgcctccgg  tcacgctga  60
gatccagaa  catgactga  tccaagtac  tcacaacca  taagaaggg  gaaatcttt  120
aattaaaag  tgaactcaa  aatgaaaag  aagaaaaga  gaaggaggc  gtgaagaaa  180
tgattgctg  tatgactgt  gggaaagac  ttagctctc  cttcccaga  gtggtgaac  240
gtatgcaga  tgacaacct  gaactaaag  agcttgtgt  cctctatct  atgaactat  300
ccaagagtc  gccagacat  gccatcatg  ctgtcaaca  ctttgtgaa  gattgtgaa  360
accccaatc  tttgattcg  gccttggca  ttagaacca  gggatgcat  cgggtggac  420
agattacag  gtatctctg  gaacccctc  gcaagtgct  gaaggatga  gacccctat  480
ttcggaaaa  agcagcagt  tgcgtggca  aactccatg  tatcaatgc  cagatggtg  540
aagatcagg  atttctgga  tctctgcgg  atctcatag  agattcaaa  ccaatggtg  600
tggctaatg  tgtagcagc  ttgtctgag  tcagtgagt  tcacccaaa  agcaactta  660
ttgatctga  ccctcagaa  atcaataag  tgctcacag  cctgaatga  tgcactgag  720
ggggccaga  tttcatctt  gactgcctg  ctaattaca  ccctaaaga  gaccgggaa  780
ctcagagca  ctgtgagcg  gtgacgcct  ggctctctc  tgccaattc  gcagtggtg  840
tttcagcag  aaaagttct  atgaagttt  tagagttgt  acccaagga  tctgactac  900
acaatatgc  gctaaagaa  ctagcgcct  cacttgtca  tttgctctc  ggggagcca  960
aagtgcagt  tgttgccct  aggaacatc  acctaattg  ccagaaaag  cctgaaatc  1020
tgaagcagg  aatcaaggt  ttctttgtg  agtacaatg  tcctatcta  gttaaacta  1080
agaagttag  catcatgat  cgtcttgca  cccaagcca  cattgctca  gttctggca  1140
aactgaagg  atatgccac  gaagttgat  tggactttg  tcgcaaagc  gtgagggcc  1200
ttggacggt  tgccatcaa  gtggagcaa  cagcagaac  ctgtgtgag  acactgctt  1260
atctaatcc  gaccaaagt  aattatgtg  tccaagagg  aattgttgt  atcagggac  1320
tcttccgaa  ataccccaa  aagtatgag  gcattatcg  cacgctgtg  gagaacttg  1380
actccctgg  tgaacccga  gcccgagcg  ctatgattt  gattgtagg  gagtatgct  1440
aaagaatcg  taatgccga  gagttacta  agagcttcc  ggaaggttt  catgatgaa  1500
gcacccagg  gcagctcac  ttgcttacc  ccatagtga  actgtttct  aagaagcca  1560
cagaaacac  ggagctggt  caacaggtc  tgagcttgg  cacacagga  tctgataat  1620
ctgaccttc  agatcgggg  tatatttat  ggcgccttc  ttcaactga  cctgtgaca  1680
ccaaagaag  agtgttgtc  gagaagcca  tgatctctg  ggaaacaga  ctcattgaa  1740
ctaccctcc  ggatgagct  atctgccac  ttggttctt  ggcctccgt  taccataaa  1800
ctccgaatg  ttttgtgga  gggagccat  gcattcatc  caaacactt  ccaattcac  1860
atgggagca  tgatgcagg  gatagccct  ttggcacca  cactgcaac  aacctggaa  1920
agcctcagg  catcccctc  caaggtgac  ttctggggg  tcttttaaa  cttgacctg  1980
gtcccccag  gaatgtccc  caagtgtcc  ccatgcaga  gggagcagt  gatctttta  2040
gaggaggac  ggatagcct  gtaggacag  ccttcatcc  gtcatcagt  cctgcaacc  2100
tcgctcctt  acctactcc  gctgtggtc  gcagtggtc  gaatgacct  tttgagctt  2160
ccactggga  aggcatggc  cctggcgga  atgtggctc  taaggcagt  tggctacct  2220
ctgtaaagg  taaaggctt  gagatttcg  ggacgttta  tcaccgcca  gggcacatc  2280
atatggaaa  gaacttcac  aacaaagct  tgcagcaca  gacggattt  gccatccag  2340
ttaacaaga  tagcttcgg  gtcatcccg  gcactccct  ggccataca  actccgctg  2400
tgccaaacc  gagcattga  gtgtctctg  ctctcaaca  cttgggccc  gtcatgaag  2460
tggagcctc  gaataactt  caggtggct  ttaaaaaca  tattgatgt  ttctacttc  2520
gctgcctca  cccactcaa  gtgcttttt  tagaagatg  caaaatgga  cgccaggtc  2580
tccttgcga  gtggaagga  attcccaat  aaaatgagc  ccaatttca  attaaggag  2640
gtcatttaa  cgctgacac  gtttccagc  agttgcaaa  caacaatgt  tacactatc  2700
ccaagagga  tgtggaggg  caggacatg  tgtaccagt  cctgaagct  actaatggc  2760
tttggattt  ggcagagct  cggatccag  caggaaacc  caattatac  ctgtcgctg  2820
agtgtagag  ccctgaagt  tctcagtac  tctatcagg  ctacgacag  attttgaaa  2880
actaataaa  gggtccagt  agcctgtaa  cagtgcaag  cacgaactc  taactgaaa  2940
acactgtat  gttgtgtag  gcctgaacc  aaaccctgc  gtacccacc  cggtagtgg  3000
cagtcattt  gtgctgata  tagcactca  cccattggt  ggttagctt  ccgtgacat  3060
tccttccac  atcgcccac  tctgccacc  gccgctgct  tctgtcctt  gttgtgagt  3120
cctctgtgc  gtgccaatg  ctagccttt  ctacaccct  ttttgagtg  agtttgata  3180
tttgtaatc  aaagctcat  tcacaagca  aaaaaggca  caagttaat  agagcgagg  3240
agagtgtca  tgaaacata  actgcacct  attgtttta  atttttgta  agatgagat  3300
gatattgag  tagaacgct  agtagaaag  gtgactgac  ctcctcaga  acagtctta  3360
tggagacat  tggccctgg  cccttctgg  caaggagag  cgaccccac  cctggtctt  3420
tgcattttc  ccttggcca  gccttccag  tctcttatg  ccatgctct  tcatttg  3477



<210> 3661
<211> 937
<212> PRT
<213> Rattus norvegicus
<308> P21851
<400> 3661

Met Thr Asp Ser Lys Tyr Phe Thr Thr Asn Lys Lys Gly Glu Ile Phe 
  1               5                  10                  15
Glu Leu Lys Ala Glu Leu Asn Asn Glu Lys Lys Glu Lys Arg Lys Glu 
             20                  25                  30
Ala Val Lys Lys Val Ile Ala Ala Met Thr Val Gly Lys Asp Val Ser 
         35                  40                  45
Ser Leu Phe Pro Asp Val Val Asn Cys Met Gln Thr Asp Asn Leu Glu 
     50                  55                  60
Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
 65                  70                  75                  80
Pro Asp Met Ala Ile Met Ala Val Asn Ser Phe Val Lys Asp Cys Glu 
                 85                  90                  95
Asp Pro Asn Pro Leu Ile Arg Ala Leu Ala Val Arg Thr Met Gly Cys 
             100                105                110
Ile Arg Val Asp Lys Ile Thr Glu Tyr Leu Cys Glu Pro Leu Arg Lys 
         115                120                125
Cys Leu Lys Asp Glu Asp Pro Tyr Val Arg Lys Thr Ala Ala Val Cys 
     130                135                140
Val Ala Lys Leu His Asp Ile Asn Ala Gln Met Val Glu Asp Gln Gly 
 145                150                155                160
Phe Leu Asp Ser Leu Arg Asp Leu Ile Ala Asp Ser Asn Pro Met Val 
                 165                170                175
Val Ala Asn Ala Val Ala Ala Leu Ser Glu Ile Ser Glu Ser His Pro 
             180                185                190
Asn Ser Asn Leu Leu Asp Leu Asn Pro Gln Asn Ile Asn Lys Leu Leu 
         195                200                205
Thr Ala Leu Asn Glu Cys Thr Glu Trp Gly Gln Ile Phe Ile Leu Asp 
     210                215                220
Cys Leu Ser Asn Tyr Asn Pro Lys Asp Asp Arg Glu Ala Gln Ser Ile 
 225                230                235                240
Cys Glu Arg Val Thr Pro Arg Leu Ser His Ala Asn Ser Ala Val Val 
                 245                250                255
Leu Ser Ala Val Lys Val Leu Met Lys Phe Leu Glu Leu Leu Pro Lys 
             260                265                270
Asp Ser Asp Tyr Tyr Asn Met Leu Leu Lys Lys Leu Ala Pro Pro Leu 
         275                280                285
Val Thr Leu Leu Ser Gly Glu Pro Glu Val Gln Tyr Val Ala Leu Arg 
     290                295                300
Asn Ile Asn Leu Ile Val Gln Lys Arg Pro Glu Ile Leu Lys Gln Glu 
 305                310                315                320
Ile Lys Val Phe Phe Val Lys Tyr Asn Asp Pro Ile Tyr Val Lys Leu 
                 325                330                335
Glu Lys Leu Asp Ile Met Ile Arg Leu Ala Ser Gln Ala Asn Ile Ala 
             340                345                350
Gln Val Leu Ala Glu Leu Lys Glu Tyr Ala Thr Glu Val Asp Val Asp 
         355                360                365
Phe Val Arg Lys Ala Val Arg Ala Ile Gly Arg Cys Ala Ile Lys Val 
     370                375                380
Glu Gln Ser Ala Glu Arg Cys Val Ser Thr Leu Leu Asp Leu Ile Gln 
 385                390                395                400
Thr Lys Val Asn Tyr Val Val Gln Glu Ala Ile Val Val Ile Arg Asp 
                 405                410                415
Ile Phe Arg Lys Tyr Pro Asn Lys Tyr Glu Ser Ile Ile Ala Thr Leu 
             420                425                430
Cys Glu Asn Leu Asp Ser Leu Asp Glu Pro Asp Ala Arg Ala Ala Met 
         435                440                445
Ile Trp Ile Val Gly Glu Tyr Ala Glu Arg Ile Asp Asn Ala Asp Glu 
     450                455                460
Leu Leu Glu Ser Phe Leu Glu Gly Phe His Asp Glu Ser Thr Gln Val 
 465                470                475                480
Gln Leu Thr Leu Leu Thr Ala Ile Val Lys Leu Phe Leu Lys Lys Pro 
                 485                490                495
Ser Glu Thr Gln Glu Leu Val Gln Gln Val Leu Ser Leu Ala Thr Gln 
             500                505                510
Asp Ser Asp Asn Pro Asp Leu Arg Asp Arg Gly Tyr Ile Tyr Trp Arg 
         515                520                525
Leu Leu Ser Thr Asp Pro Val Thr Ala Lys Glu Val Val Leu Ser Glu 
     530                535                540
Lys Pro Leu Ile Ser Glu Glu Thr Asp Leu Ile Glu Pro Thr Leu Leu 
 545                550                555                560
Asp Glu Leu Ile Cys His Ile Gly Ser Leu Ala Ser Val Tyr His Lys 
                 565                570                575
Pro Pro Asn Ala Phe Val Glu Gly Ser His Gly Ile His Arg Lys His 
             580                585                590
Leu Pro Ile His His Gly Ser Thr Asp Ala Gly Asp Ser Pro Val Gly 
         595                600                605
Thr Thr Thr Ala Thr Asn Leu Glu Gln Pro Gln Val Ile Pro Ser Gln 
     610                615                620
Gly Asp Leu Leu Gly Asp Leu Leu Asn Leu Asp Leu Gly Pro Pro Val 
 625                630                635                640
Asn Val Pro Gln Val Ser Ser Met Gln Met Gly Ala Val Asp Leu Leu 
                 645                650                655
Gly Gly Gly Leu Asp Ser Leu Val Gly Gln Ser Phe Ile Pro Ser Ser 
             660                665                670
Val Pro Ala Thr Phe Ala Pro Ser Pro Thr Pro Ala Val Val Ser Ser 
         675                680                685
Gly Leu Asn Asp Leu Phe Glu Leu Ser Thr Gly Ile Gly Met Ala Pro 
     690                695                700
Gly Gly Tyr Val Ala Pro Lys Ala Val Trp Leu Pro Ala Val Lys Ala 
 705                710                715                720
Lys Gly Leu Glu Ile Ser Gly Thr Phe Thr His Arg Gln Gly His Ile 
                 725                730                735
Tyr Met Glu Met Asn Phe Thr Asn Lys Ala Leu Gln His Met Thr Asp 
             740                745                750
Phe Ala Ile Gln Phe Asn Lys Asn Ser Phe Gly Val Ile Pro Ser Thr 
         755                760                765
Pro Leu Ala Ile His Thr Pro Leu Met Pro Asn Gln Ser Ile Asp Val 
     770                775                780
Ser Leu Pro Leu Asn Thr Leu Gly Pro Val Met Lys Met Glu Pro Leu 
 785                790                795                800
Asn Asn Leu Gln Val Ala Val Lys Asn Asn Ile Asp Val Phe Tyr Phe 
                 805                810                815
Ser Cys Leu Ile Pro Leu Asn Val Leu Phe Val Glu Asp Gly Lys Met 
             820                825                830
Glu Arg Gln Val Phe Leu Ala Thr Trp Lys Asp Ile Pro Asn Glu Asn 
         835                840                845
Glu Leu Gln Phe Gln Ile Lys Glu Cys His Leu Asn Ala Asp Thr Val 
     850                855                860
Ser Ser Lys Leu Gln Asn Asn Asn Val Tyr Thr Ile Ala Lys Arg Asn 
 865                870                875                880
Val Glu Gly Gln Asp Met Leu Tyr Gln Ser Leu Lys Leu Thr Asn Gly 
                 885                890                895
Ile Trp Ile Leu Ala Glu Leu Arg Ile Gln Pro Gly Asn Pro Asn Tyr 
             900                905                910
Thr Leu Ser Leu Lys Cys Arg Ala Pro Glu Val Ser Gln Tyr Ile Tyr 
         915                920                925
Gln Val Tyr Asp Ser Ile Leu Lys Asn 
     930                935



<210> 3662
<211> 5701
<212> DNA
<213> Homo sapiens
<308> M34175
<400> 3662

ctgcccacc  tctttgtcc  tggcaaagt  ggttttgcg  agtggctta  acctagaaa  60
gaatcgtga  gggcaggaa  ccattacac  accacctgg  ctgtgctct  cggctcccg  120
cgccacccc  gccctcgcc  tcgcctccg  tccggtgca  attaaagat  caaagtcat  180
actgactcc  agtatttca  aaccaataa  aaaggagaa  tatttgaac  aaaagctga  240
ctcaacaat  aaaagaaag  aaagagaaa  gaggctgtg  agaaagtga  tgctgctat  300
accgtgggg  aggatgtta  ttctctctt  ccagacgta  tgaactgta  gcagactga  360
aatctggaa  taaagaagc  tgtgtatct  tacttgatg  actacgcca  gagtcagcc  420
gacatggcc  tcatggctg  aaacagctt  gtgaaggac  gtgaagatc  taatccttt  480
attcgagcc  tggcagtca  aaccatggg  tgcatccgg  tagacaaaa  tacagaata  540
ctctgtgag  cgctccgca  gtgcttgaa  gatgaggat  cctatgttc  gaaaacagc  600
gcagtctgc  tggcaaaac  ccatgatat  aatgcccaa  tggtggaag  tcagggatt  660
ctggattct  tacgggatc  catagcaga  tcaaatcca  tggtggtgg  taatgccgt  720
gcggcatta  ctgaaatca  tgagtctca  ccaaacagc  acttacttg  tctgaaccc  780
cagaacatt  ataagctgc  gacagccct  aatgaatgc  ctgaatggg  ccagatttt  840
atcctggac  gcctgtcta  ttacaaccc  aaagatgat  gggaggctc  gagcatctg  900
gagcgggta  ctccccggc  atcccatgc  aactcagca  tggtgcttt  agcggtaaa  960
gtcctaatg  agtttctag  attgttacc  aaggattct  actactaca  tatgctgct  1020
aagaagtta  cccctccac  tgtcacttt  ctgtctggg  agccagaag  gcagtatgt  1080
gccctgagg  acatcaact  aattgtcca  aaaaggcct  aaatcttga  gcaggaaat  1140
aaagtcttc  ttgtgaagt  caatgatcc  atctatgtt  aactagaga  gttggacat  1200
atgattcgt  tggcatctc  agccaacat  gctcaggtt  tggcagaac  gaaagaata  1260
gctacagag  tggatgttg  ctttgttcg  aaagctgtg  gggccattg  acggtgtgc  1320
atcaaggtg  agcaatctg  agagcgctg  gtaagcaca  tgcttgatc  aatccagac  1380
aaagtgaat  atgtggtcc  agaagcaat  gttgtcatc  gggacatct  ccgcaaata  1440
cccaacaag  atgaaagta  catcgccac  ctgtgtgag  acttagact  gctggatga  1500
ccagatgct  gagcagcta  gatttggat  gtgggagaa  atgctgaaa  aattgacaa  1560
gcagatgag  tactagaaa  cttcctgga  ggttttcac  atgaaagca  ccaggtgca  1620
ctcactctg  ttactgcca  agtgaagct  tttctcaag  aaccatcag  aacacagga  1680
ctagtccag  aggtcttga  tttggcaac  caggattct  ataatcctg  ccttcgaga  1740
cggggctat  tttattggc  ccttctctc  actgaccct  ttacagcta  agaagtagt  1800
ttgtctgag  agccactga  ctctgagga  acggacctt  ttgagccaa  tctgctgga  1860
gagctaatc  gccacattg  ttctttggc  tctgtgtat  ataagcctc  caatgcttt  1920
gtggaagga  gtcatggaa  tcatcgtaa  cacttgcca  ttcatcatg  gagcactga  1980
gcaggtgac  gccctgttg  cactaccac  gcaacgaac  tggaacagc  tcaggttat  2040
ccctctcaa  gtgatcttc  aggggatct  ttaaacctt  acctcggtc  cccagtcaa  2100
gtgccacag  tgtcctcca  gcagatggg  gcagtggat  tcctaggag  aggactaga  2160
agtctggtg  gacaatcct  catcccatc  tcggtgcct  caacctttg  tccttcacc  2220
acacctgct  tggtcagca  tggactgaa  gacctgttt  aactctcca  agggatagg  2280
atggcacct  gtggatatg  ggctcctaa  gctgtctgg  tacctgcag  aaaggctaa  2340
ggcttggag  tttccggaa  atttactca  cgccaaggg  acatctata  ggaaatgaa  2400
ttcaccaat  aagctctgc  gcacatgac  gattttgca  tccagttta  caaaaatag  2460
tttggtgtc  tccccagca  tcctctggc  atccataca  cactgatgc  aaaccagag  2520
attgatgtc  ccctgcctc  caatacctt  ggcccagtc  tgaagatgg  acctctgaa  2580
aacctccag  tggctgtga  aaacaatat  gatgtcttc  acttcagct  cctcatccc  2640
ctcaatgtg  tttttgtag  agatggcaa  atggagcgc  aggtcttcc  tgcaacatg  2700
aaggatatt  ccaatgaaa  tgaacttca  tttcagatt  aggaatgtc  tttaaatgc  2760
gacactgtt  ccagcaagt  gcaaaacaa  aatgtttat  ctattgcca  gaggaatgt  2820
gaagggcag  acatgctgt  ccaatccct  aagctcact  atggcattt  gattttggc  2880
gaactacgt  tccagccag  aaaccccaa  tacacgctg  cactgaagt  tagagctcc  2940
gaagtctct  aatacatct  tcaggtcta  gacagcatt  tgaaaaact  acaagactg  3000
tccagtacc  ttcaaccat  ctgtgatcg  tgcaagtca  gaactctta  ctggaagaa  3060
ttgtattgc  gcgtagaat  tgaacacac  gaggccacc  agcaaggta  taactagtc  3120
aacctgtgc  aacattagg  cacaacctg  tggatagtt  tagcttcct  tgaacattt  3180
taaccactg  ttcagtcac  tcccacctc  tgccacctg  tgctgctat  tgtccttac  3240
tgtgggctt  tccatgctg  gccaatggc  ggctttttc  acaccctct  ttgagtgta  3300
tttggtatt  tgtaattga  agctcattt  aaaagcaga  aaagacaac  aatattaaa  3360
caaggaaaa  tgtaactga  acactgcac  ttactgttt  atacttttg  acatatgag  3420
aatcaaggg  ttagtgcaa  cagtagaag  cattgaaat  actgtcatt  accacacag  3480
cctggaggc  gagatgcag  tacctaccc  agcttttga  gggttctct  acctgtagt  3540
gccttatcc  tggtcattt  gattttcag  ttgcttttt  ctttttttc  cctccaaac  3600
ccttttcct  ggccaagcc  tcatgcttc  ccctttcca  attataatc  catttgatt  3660
ctctgcagt  gggaacggt  atcttcttg  atgatgttt  agtgtgcaa  aactataga  3720
cctgtcagc  ccaaagctg  cagaagtta  accttactc  tttcctttc  cctgaacaa  3780
cctgctaat  ccactaatt  aggaatttg  gtagagatg  ggaacaaga  cccagatgc  3840
gtcccctca  cccctctcc  gtatttctc  ggtccagtt  aaatctaaa  ttctacttt  3900
agagttgaa  cagagtaat  acttatcta  ccctctttt  ctacaaagg  gaaagataa  3960
aggcacaaa  gttaccgcc  aggcccgtc  gctgtgtag  ggcaaagcc  agaccgagt  4020
tcctaagtc  ccgtcagtg  ggttttcac  acaggactg  ctcttgtcg  tttccccta  4080
tgccttctc  tgccttttc  gtgcctagt  tttggctct  cacatattc  atattgatt  4140
tgacgctct  tatattggc  tcaggtggc  gctgaatat  ttttgaatt  ctcgaaggt  4200
aagccagat  ccagaatga  ggtgtagcc  gtgtttccc  tatgcccct  gagccccac  4260
tattgaggc  agcagaata  gtgcagaga  gaagtgagc  tagagatgt  gcaaatgct  4320
tttatccct  cagctctct  atctgctct  tcttcatga  acttagtct  cagggcata  4380
taagatcat  ccagaggtt  aggcagttc  tgtcatctc  gaaaagact  ggggatatg  4440
aatcttccc  ctaccccac  taatgcgtt  gatatgatt  ttcaaagaa  gcttcatgc  4500
caaaatacc  gcctgttta  cagtgttac  ctgtttgat  tgcgggcac  tgttgcatt  4560
cctggcacc  aatattcag  gtccatgac  aagactggt  ttctcagat  ccctgctta  4620
atcaggggc  cttcaggct  cacaggcgt  atgttggac  gagacctaa  tcactggac  4680
cagaggagg  atcgtggaa  acaagagca  aactacccc  cacccctat  tcatgtctg  4740
aataaccct  tttcatacc  gttgcaaag  ttgtgggga  cggtcccac  aagcacttt  4800
ttaaacctt  agaatctcc  agagaaaaa  atttgggga  ggagggagg  aatatgtcc  4860
ttgcacacc  cccctgaag  acatggcag  aggaaacag  ataggattg  atgtgggag  4920
tggataggt  ggtgatgtg  ggagcggaa  agcaggttg  taaagttcc  ttcttggga  4980
ttattcctg  agtcagtgg  tacaagtag  gcagaaggt  cacactgca  atagtgttc  5040
catctcaaa  caaactatc  ttccagaag  aaaagtgtg  cagggcaag  agacaacac  5100
atttcctat  agaatatgt  cctcaaccc  cgaaacaag  cttctctca  cctccccac  5160
agtgatgga  aacagctcc  attctcagc  gacctgact  agccaaccc  tgaactctt  5220
actccttgg  gaagccacc  cccatcaca  ccctgagca  agttaggga  gaattctac  5280
tcccataaa  ggacctctc  tgagaggca  aacctgttg  ctccaccac  gcttccctc  5340
tggctcatt  caagcttgg  caaattggg  aagtgggat  gaggttgcc  tgcatcccc  5400
ctcctctgc  tgagtgtgt  tttgtaatg  cagctggca  catacaaag  gcaggagaa  5460
caaacaccc  gaactcttt  gctggtcag  gattccctg  gtgtctgtc  tcacccaag  5520
ctgctctgt  tctgtgttg  gaagcttga  actctggaa  gaaatgggg  gggggggca  5580
gggaaatgt  gccctaaga  tgcttctca  tcctctgtt  ttattgggt  ctgtttttc  5640
ggagggtgg  ggttggggg  agcttgacc  tgtgtcttc  tcaataaac  cacatttac  5700
c  5701



<210> 3663
<211> 937
<212> PRT
<213> Homo sapiens
<308> P21851
<400> 3663

Met Thr Asp Ser Lys Tyr Phe Thr Thr Asn Lys Lys Gly Glu Ile Phe 
  1               5                  10                  15
Glu Leu Lys Ala Glu Leu Asn Asn Glu Lys Lys Glu Lys Arg Lys Glu 
             20                  25                  30
Ala Val Lys Lys Val Ile Ala Ala Met Thr Val Gly Lys Asp Val Ser 
         35                  40                  45
Ser Leu Phe Pro Asp Val Val Asn Cys Met Gln Thr Asp Asn Leu Glu 
     50                  55                  60
Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
 65                  70                  75                  80
Pro Asp Met Ala Ile Met Ala Val Asn Ser Phe Val Lys Asp Cys Glu 
                 85                  90                  95
Asp Pro Asn Pro Leu Ile Arg Ala Leu Ala Val Arg Thr Met Gly Cys 
             100                105                110
Ile Arg Val Asp Lys Ile Thr Glu Tyr Leu Cys Glu Pro Leu Arg Lys 
         115                120                125
Cys Leu Lys Asp Glu Asp Pro Tyr Val Arg Lys Thr Ala Ala Val Cys 
     130                135                140
Val Ala Lys Leu His Asp Ile Asn Ala Gln Met Val Glu Asp Gln Gly 
 145                150                155                160
Phe Leu Asp Ser Leu Arg Asp Leu Ile Ala Asp Ser Asn Pro Met Val 
                 165                170                175
Val Ala Asn Ala Val Ala Ala Leu Ser Glu Ile Ser Glu Ser His Pro 
             180                185                190
Asn Ser Asn Leu Leu Asp Leu Asn Pro Gln Asn Ile Asn Lys Leu Leu 
         195                200                205
Thr Ala Leu Asn Glu Cys Thr Glu Trp Gly Gln Ile Phe Ile Leu Asp 
     210                215                220
Cys Leu Ser Asn Tyr Asn Pro Lys Asp Asp Arg Glu Ala Gln Ser Ile 
 225                230                235                240
Cys Glu Arg Val Thr Pro Arg Leu Ser His Ala Asn Ser Ala Val Val 
                 245                250                255
Leu Ser Ala Val Lys Val Leu Met Lys Phe Leu Glu Leu Leu Pro Lys 
             260                265                270
Asp Ser Asp Tyr Tyr Asn Met Leu Leu Lys Lys Leu Ala Pro Pro Leu 
         275                280                285
Val Thr Leu Leu Ser Gly Glu Pro Glu Val Gln Tyr Val Ala Leu Arg 
     290                295                300
Asn Ile Asn Leu Ile Val Gln Lys Arg Pro Glu Ile Leu Lys Gln Glu 
 305                310                315                320
Ile Lys Val Phe Phe Val Lys Tyr Asn Asp Pro Ile Tyr Val Lys Leu 
                 325                330                335
Glu Lys Leu Asp Ile Met Ile Arg Leu Ala Ser Gln Ala Asn Ile Ala 
             340                345                350
Gln Val Leu Ala Glu Leu Lys Glu Tyr Ala Thr Glu Val Asp Val Asp 
         355                360                365
Phe Val Arg Lys Ala Val Arg Ala Ile Gly Arg Cys Ala Ile Lys Val 
     370                375                380
Glu Gln Ser Ala Glu Arg Cys Val Ser Thr Leu Leu Asp Leu Ile Gln 
 385                390                395                400
Thr Lys Val Asn Tyr Val Val Gln Glu Ala Ile Val Val Ile Arg Asp 
                 405                410                415
Ile Phe Arg Lys Tyr Pro Asn Lys Tyr Glu Ser Ile Ile Ala Thr Leu 
             420                425                430
Cys Glu Asn Leu Asp Ser Leu Asp Glu Pro Asp Ala Arg Ala Ala Met 
         435                440                445
Ile Trp Ile Val Gly Glu Tyr Ala Glu Arg Ile Asp Asn Ala Asp Glu 
     450                455                460
Leu Leu Glu Ser Phe Leu Glu Gly Phe His Asp Glu Ser Thr Gln Val 
 465                470                475                480
Gln Leu Thr Leu Leu Thr Ala Ile Val Lys Leu Phe Leu Lys Lys Pro 
                 485                490                495
Ser Glu Thr Gln Glu Leu Val Gln Gln Val Leu Ser Leu Ala Thr Gln 
             500                505                510
Asp Ser Asp Asn Pro Asp Leu Arg Asp Arg Gly Tyr Ile Tyr Trp Arg 
         515                520                525
Leu Leu Ser Thr Asp Pro Val Thr Ala Lys Glu Val Val Leu Ser Glu 
     530                535                540
Lys Pro Leu Ile Ser Glu Glu Thr Asp Leu Ile Glu Pro Thr Leu Leu 
 545                550                555                560
Asp Glu Leu Ile Cys His Ile Gly Ser Leu Ala Ser Val Tyr His Lys 
                 565                570                575
Pro Pro Asn Ala Phe Val Glu Gly Ser His Gly Ile His Arg Lys His 
             580                585                590
Leu Pro Ile His His Gly Ser Thr Asp Ala Gly Asp Ser Pro Val Gly 
         595                600                605
Thr Thr Thr Ala Thr Asn Leu Glu Gln Pro Gln Val Ile Pro Ser Gln 
     610                615                620
Gly Asp Leu Leu Gly Asp Leu Leu Asn Leu Asp Leu Gly Pro Pro Val 
 625                630                635                640
Asn Val Pro Gln Val Ser Ser Met Gln Met Gly Ala Val Asp Leu Leu 
                 645                650                655
Gly Gly Gly Leu Asp Ser Leu Val Gly Gln Ser Phe Ile Pro Ser Ser 
             660                665                670
Val Pro Ala Thr Phe Ala Pro Ser Pro Thr Pro Ala Val Val Ser Ser 
         675                680                685
Gly Leu Asn Asp Leu Phe Glu Leu Ser Thr Gly Ile Gly Met Ala Pro 
     690                695                700
Gly Gly Tyr Val Ala Pro Lys Ala Val Trp Leu Pro Ala Val Lys Ala 
 705                710                715                720
Lys Gly Leu Glu Ile Ser Gly Thr Phe Thr His Arg Gln Gly His Ile 
                 725                730                735
Tyr Met Glu Met Asn Phe Thr Asn Lys Ala Leu Gln His Met Thr Asp 
             740                745                750
Phe Ala Ile Gln Phe Asn Lys Asn Ser Phe Gly Val Ile Pro Ser Thr 
         755                760                765
Pro Leu Ala Ile His Thr Pro Leu Met Pro Asn Gln Ser Ile Asp Val 
     770                775                780
Ser Leu Pro Leu Asn Thr Leu Gly Pro Val Met Lys Met Glu Pro Leu 
 785                790                795                800
Asn Asn Leu Gln Val Ala Val Lys Asn Asn Ile Asp Val Phe Tyr Phe 
                 805                810                815
Ser Cys Leu Ile Pro Leu Asn Val Leu Phe Val Glu Asp Gly Lys Met 
             820                825                830
Glu Arg Gln Val Phe Leu Ala Thr Trp Lys Asp Ile Pro Asn Glu Asn 
         835                840                845
Glu Leu Gln Phe Gln Ile Lys Glu Cys His Leu Asn Ala Asp Thr Val 
     850                855                860
Ser Ser Lys Leu Gln Asn Asn Asn Val Tyr Thr Ile Ala Lys Arg Asn 
 865                870                875                880
Val Glu Gly Gln Asp Met Leu Tyr Gln Ser Leu Lys Leu Thr Asn Gly 
                 885                890                895
Ile Trp Ile Leu Ala Glu Leu Arg Ile Gln Pro Gly Asn Pro Asn Tyr 
             900                905                910
Thr Leu Ser Leu Lys Cys Arg Ala Pro Glu Val Ser Gln Tyr Ile Tyr 
         915                920                925
Gln Val Tyr Asp Ser Ile Leu Lys Asn 
     930                935



<210> 3664
<211> 2078
<212> DNA
<213> Rattus norvegicus
<308> M34253
<400> 3664

ctcgacgaa  gagtaggac  agctctcac  gtctgagcc  aaccgaacc  ggccgagct  60
agccgaggt  agcggtggc  agaggaacc  agcatctcg  gcatcattc  ctccgtgca  120
gcatcgtgt  cctacaccg  aactccgtg  ctcattccc  ggtaccctc  gtgactcgc  180
cctgcagca  agccaccat  cctatcact  ggatgcgaa  gagaccctg  ctagagatg  240
agattaatt  caaccaaat  ccagggctg  gctggatca  taaagaaga  atgatcttc  300
agatcccat  gaagcatgc  gccttgcac  gttgggata  caacaagga  gcctgtctg  360
tccggagct  ggccattca  acaggccga  acaaagctg  ggaaaaaga  ccagatccc  420
agacttgga  ggcaaactt  cggtgtgcc  tgaactccc  accagacat  gaggaagtg  480
aggaccaga  caggaacaa  ggcagctct  ctgtacgcg  gtaccggat  ctgccaccc  540
tcaccaaga  ccagaggaa  gagagaaag  ccaagtcca  ccgtgacac  aagagcaaa  600
ccaagagga  gctgtgcgg  gattctagc  ctgacacct  atctgacgg  ctgagcagc  660
ctactctgc  tgatgacca  agcagttac  cagctcagg  atacctggg  caggacttg  720
acatggaca  ggacattac  ccagctctg  caccgtgcg  cgtcagcag  agtctctct  780
agtggcata  gcagatgga  atcatgcca  acagcacca  tgatctgta  aacttgcag  840
tgtcgccca  gccctccac  tctgaagct  caacagatg  ggatgagga  gggaagtta  900
ctgaggaca  catgaagct  tttgaacag  ctgagtggc  gccgacgca  gtggatggc  960
agggatact  gctcaatga  ccaggagcc  aactctcta  tgtctatgg  gacttcagc  1020
gcaaggagg  accagagat  gacagccct  gaggggaca  cgagatagg  atacagcgt  1080
tcttcacag  gatgaagaa  atggacccc  tcatgtgga  ggacaccct  ctgggcaac  1140
ctaccaggc  gccctccat  caggctatt  cttgtgcac  ataatttgg  tccctgacc  1200
gttcttgcc  tcctgagtg  gctaggtcc  gcatcatgg  ggctgtgat  caacataaa  1260
ctaaacttc  gtggacccc  tgatgtggc  aaacataat  ccattgcca  gcagggaag  1320
gaccaaacc  tcctccttg  gtcagtgga  tgactcttc  gagcttagg  ggcagggtc  1380
aagtttttc  agctggtcc  gactcctag  aagatggat  ggcgttctg  ggttagtgt  1440
aggcagagg  cctggacgg  agttacctt  tagctcttt  aaagcttca  tgcttagag  1500
gggtctcac  actgggctg  cctggggga  agaccagcg  ccacagaag  gcattgcac  1560
ggccttagg  ctggctcca  actgggaga  aattgcact  agtcctatt  ccaaagaac  1620
gctgccctt  ccaaccgag  cctgggatg  ttctagagc  agtgaaatg  gaaggaaaa  1680
atggggtcc  gtgagggtt  tctccctta  cctcagagg  attctgcct  actccctgc  1740
ccagctgtg  ggctcagga  aaaaaaatg  cactttctc  gtggacttt  ccacatttc  1800
gatcagaag  gtacactaa  atttctccc  agtcttggc  tttgcattt  tttatatag  1860
gccttgccc  gtgcctgct  tctctcctc  ggcctcagc  gtcctcagc  ggcccaggg  1920
gggggttgt  agcgccttg  cgtgactct  aacattgga  acgccacct  actactaag  1980
tgtgtctga  ctcgtgtgg  tctgtgtaa  tatgtatat  catcttttt  taaaaacct  2040
agttgttta  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  2078



<210> 3665
<211> 328
<212> PRT
<213> Rattus norvegicus
<308> P23570
<400> 3665

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
  1               5                  10                  15
Asn Ser Asn Gln Ile Pro Gly Leu Ser Trp Ile Asn Lys Glu Glu Met 
             20                  25                  30
Ile Phe Gln Ile Pro Trp Lys His Ala Ala Leu His Gly Trp Asp Ile 
         35                  40                  45
Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg 
     50                  55                  60
Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn 
 65                  70                  75                  80
Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                 85                  90                  95
Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu 
             100                105                110
Pro Pro Leu Thr Lys Asn Gln Arg Lys Glu Arg Lys Ser Lys Ser Ser 
         115                120                125
Arg Asp Thr Lys Ser Lys Thr Lys Arg Lys Leu Cys Gly Asp Ser Ser 
     130                135                140
Pro Asp Thr Leu Ser Asp Gly Leu Ser Ser Ser Thr Leu Pro Asp Asp 
 145                150                155                160
His Ser Ser Tyr Thr Ala Gln Gly Tyr Leu Gly Gln Asp Leu Asp Met 
                 165                170                175
Asp Arg Asp Ile Thr Pro Ala Leu Ser Pro Cys Val Val Ser Ser Ser 
             180                185                190
Leu Ser Glu Trp His Met Gln Met Asp Ile Met Pro Asp Ser Thr Thr 
         195                200                205
Asp Leu Tyr Asn Leu Gln Val Ser Pro Met Pro Ser Thr Ser Glu Ala 
     210                215                220
Ala Thr Asp Glu Asp Glu Glu Gly Lys Leu Pro Glu Asp Ile Met Lys 
 225                230                235                240
Leu Phe Glu Gln Ser Glu Trp Gln Pro Thr His Val Asp Gly Lys Gly 
                 245                250                255
Tyr Leu Leu Asn Glu Pro Gly Ala Gln Leu Ser Thr Val Tyr Gly Asp 
             260                265                270
Phe Ser Cys Lys Glu Glu Pro Glu Ile Asp Ser Pro Gly Gly Asp Ile 
         275                280                285
Glu Ile Gly Ile Gln Arg Val Phe Thr Glu Met Lys Asn Met Asp Pro 
     290                295                300
Val Met Trp Met Asp Thr Leu Leu Gly Asn Ser Thr Arg Pro Pro Ser 
 305                310                315                320
Ile Gln Ala Ile Pro Cys Ala Pro 
                 325



<210> 3666
<211> 2035
<212> DNA
<213> Homo sapiens
<308> X14454
<400> 3666

cgagccccg  cgaaccgag  ccacccgga  ccgtgccca  tccacgccg  ccgtgcccg  60
cggccttaa  aaccaggca  cctctgcct  cttccctct  ccactcgga  tcgcgctcc  120
cgcgccctc  ctgcagccc  tgcgtcgcc  ggaccctcg  gcgcgacca  ccgaatcgc  180
cctgcagca  agccaacat  cccatcact  ggatgcgca  gagaccctg  ctagagatg  240
agattaatt  caaccaaat  ccggggctc  tctggatta  taaagagga  atgatcttc  300
agatcccat  gaagcatgc  gccaagcat  gctgggaca  caacaagga  gcctgtttg  360
tccggagct  ggccattca  acaggccga  acaaagcag  ggaaaagga  ccagatccc  420
agacgtgga  ggccaactt  cgctgtgcc  tgaactccc  gccagatat  gaggaggtg  480
aagaccaga  caggaacaa  ggcagctca  ctgtgcgag  gtaccggat  cttccacct  540
tcaccaaga  ccagagaaa  gaaagaaag  cgaagtcca  ccgagatgc  aagagcaag  600
ccaagagga  gtcatgtgg  gattccagc  ctgatacct  ctctgatgg  ctcagcagc  660
ccactctgc  tgatgacca  agcagctac  cagttccag  ctacatgca  gacttggag  720
tggagcagg  cctgactcc  gcactgtcg  catgtgctg  cagcagcac  ctccccgac  780
ggcacatcc  agtggaagt  gtgccggac  gcaccagtg  tctgtacaa  ttccaggtg  840
cacccatgc  ctccacctc  gaagctaca  cagatgagg  tgaggaagg  aaattacct  900
aggacatca  gaagctctt  gagcagtcg  agtggcagc  aacaaacgt  gatgggaag  960
ggtacctac  caatgaacc  ggagtccag  ccacctctg  ctatggaga  tttagctgt  1020
aggaggagc  agaaattga  agcccaggg  gggatattg  gctgagtct  cagcgtgtc  1080
tcacagatc  gaagaacat  gatgccacc  ggctggaca  cctgctgac  ccagtccgg  1140
tgccctcca  ccaggccat  ccctgtgca  cgtagcagg  cccctgggc  cctcttatt  1200
ctctaggca  gcaggacct  gcatcatgg  ggatatggt  cagagaagc  ggacttctg  1260
gggcccctc  acagccaag  gtgacccca  tgccaagtg  ggatgggcc  ccctccttg  1320
gtcattgac  tctcagggc  tggcaggcc  gtgtctggg  ttttcttgt  gtgtaaagc  1380
ggccctgcc  cctgggaag  tgaggttct  agaccagtg  atcaggtca  ggacttgga  1440
aggagtcag  gtctggctt  ttcctctga  cccagctgc  tggagaggg  ctcgctgtc  1500
ctggctggc  cctagggga  cagaccagt  accccagaa  agcataaca  caatcccag  1560
gctggctct  cactaagcg  aaattgcac  aaatgaatc  cgttccaaa  aactacccc  1620
tttcagctg  gccctgggg  ctgttccaa  gccagtgaa  gtgaaggaa  ctcccctcc  1680
tcggggcaa  gctccctca  cctcagagg  gctctaccc  gctccctgc  ttggctgag  1740
ggcttggga  aaaaacttg  cactttttc  tgtggatct  gccacattt  tgatcagag  1800
tgtacacta  catttcccc  gagctcttg  cctttgcat  tatttatac  gtgccttgc  1860
cggggccca  caccccctc  agccccagc  gccctcaac  ggcccaggg  gggaagtgt  1920
agcgccttg  tatgactta  aattggaaa  gtcatctaa  cattaagtc  tgtgtgaac  1980
cataaggac  tgtgtaaat  tgtacattt  tctttttat  aaaagtaaa  ttgtt  2035



<210> 3667
<211> 325
<212> PRT
<213> Homo sapiens
<308> P10914
<400> 3667

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
  1               5                  10                  15
Asn Ser Asn Gln Ile Pro Gly Leu Ile Trp Ile Asn Lys Glu Glu Met 
             20                  25                  30
Ile Phe Gln Ile Pro Trp Lys His Ala Ala Lys His Gly Trp Asp Ile 
         35                  40                  45
Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg 
     50                  55                  60
Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn 
 65                  70                  75                  80
Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                 85                  90                  95
Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu 
             100                105                110
Pro Pro Leu Thr Lys Asn Gln Arg Lys Glu Arg Lys Ser Lys Ser Ser 
         115                120                125
Arg Asp Ala Lys Ser Lys Ala Lys Arg Lys Ser Cys Gly Asp Ser Ser 
     130                135                140
Pro Asp Thr Phe Ser Asp Gly Leu Ser Ser Ser Thr Leu Pro Asp Asp 
 145                150                155                160
His Ser Ser Tyr Thr Val Pro Gly Tyr Met Gln Asp Leu Glu Val Glu 
                 165                170                175
Gln Ala Leu Thr Pro Ala Leu Ser Pro Cys Ala Val Ser Ser Thr Leu 
             180                185                190
Pro Asp Trp His Ile Pro Val Glu Val Val Pro Asp Ser Thr Ser Asp 
         195                200                205
Leu Tyr Asn Phe Gln Val Ser Pro Met Pro Ser Thr Ser Glu Ala Thr 
     210                215                220
Thr Asp Glu Asp Glu Glu Gly Lys Leu Pro Glu Asp Ile Met Lys Leu 
 225                230                235                240
Leu Glu Gln Ser Glu Trp Gln Pro Thr Asn Val Asp Gly Lys Gly Tyr 
                 245                250                255
Leu Leu Asn Glu Pro Gly Val Gln Pro Thr Ser Val Tyr Gly Asp Phe 
             260                265                270
Ser Cys Lys Glu Glu Pro Glu Ile Asp Ser Pro Gly Gly Asp Ile Gly 
         275                280                285
Leu Ser Leu Gln Arg Val Phe Thr Asp Leu Lys Asn Met Asp Ala Thr 
     290                295                300
Trp Leu Asp Ser Leu Leu Thr Pro Val Arg Leu Pro Ser Ile Gln Ala 
 305                310                315                320
Ile Pro Cys Ala Pro 
                 325



<210> 3668
<211> 2078
<212> DNA
<213> Rattus norvegicus
<308> M34253
<400> 3668

ctcgacgaa  gagtaggac  agctctcac  gtctgagcc  aaccgaacc  ggccgagct  60
agccgaggt  agcggtggc  agaggaacc  agcatctcg  gcatcattc  ctccgtgca  120
gcatcgtgt  cctacaccg  aactccgtg  ctcattccc  ggtaccctc  gtgactcgc  180
cctgcagca  agccaccat  cctatcact  ggatgcgaa  gagaccctg  ctagagatg  240
agattaatt  caaccaaat  ccagggctg  gctggatca  taaagaaga  atgatcttc  300
agatcccat  gaagcatgc  gccttgcac  gttgggata  caacaagga  gcctgtctg  360
tccggagct  ggccattca  acaggccga  acaaagctg  ggaaaaaga  ccagatccc  420
agacttgga  ggcaaactt  cggtgtgcc  tgaactccc  accagacat  gaggaagtg  480
aggaccaga  caggaacaa  ggcagctct  ctgtacgcg  gtaccggat  ctgccaccc  540
tcaccaaga  ccagaggaa  gagagaaag  ccaagtcca  ccgtgacac  aagagcaaa  600
ccaagagga  gctgtgcgg  gattctagc  ctgacacct  atctgacgg  ctgagcagc  660
ctactctgc  tgatgacca  agcagttac  cagctcagg  atacctggg  caggacttg  720
acatggaca  ggacattac  ccagctctg  caccgtgcg  cgtcagcag  agtctctct  780
agtggcata  gcagatgga  atcatgcca  acagcacca  tgatctgta  aacttgcag  840
tgtcgccca  gccctccac  tctgaagct  caacagatg  ggatgagga  gggaagtta  900
ctgaggaca  catgaagct  tttgaacag  ctgagtggc  gccgacgca  gtggatggc  960
agggatact  gctcaatga  ccaggagcc  aactctcta  tgtctatgg  gacttcagc  1020
gcaaggagg  accagagat  gacagccct  gaggggaca  cgagatagg  atacagcgt  1080
tcttcacag  gatgaagaa  atggacccc  tcatgtgga  ggacaccct  ctgggcaac  1140
ctaccaggc  gccctccat  caggctatt  cttgtgcac  ataatttgg  tccctgacc  1200
gttcttgcc  tcctgagtg  gctaggtcc  gcatcatgg  ggctgtgat  caacataaa  1260
ctaaacttc  gtggacccc  tgatgtggc  aaacataat  ccattgcca  gcagggaag  1320
gaccaaacc  tcctccttg  gtcagtgga  tgactcttc  gagcttagg  ggcagggtc  1380
aagtttttc  agctggtcc  gactcctag  aagatggat  ggcgttctg  ggttagtgt  1440
aggcagagg  cctggacgg  agttacctt  tagctcttt  aaagcttca  tgcttagag  1500
gggtctcac  actgggctg  cctggggga  agaccagcg  ccacagaag  gcattgcac  1560
ggccttagg  ctggctcca  actgggaga  aattgcact  agtcctatt  ccaaagaac  1620
gctgccctt  ccaaccgag  cctgggatg  ttctagagc  agtgaaatg  gaaggaaaa  1680
atggggtcc  gtgagggtt  tctccctta  cctcagagg  attctgcct  actccctgc  1740
ccagctgtg  ggctcagga  aaaaaaatg  cactttctc  gtggacttt  ccacatttc  1800
gatcagaag  gtacactaa  atttctccc  agtcttggc  tttgcattt  tttatatag  1860
gccttgccc  gtgcctgct  tctctcctc  ggcctcagc  gtcctcagc  ggcccaggg  1920
gggggttgt  agcgccttg  cgtgactct  aacattgga  acgccacct  actactaag  1980
tgtgtctga  ctcgtgtgg  tctgtgtaa  tatgtatat  catcttttt  taaaaacct  2040
agttgttta  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  2078



<210> 3669
<211> 328
<212> PRT
<213> Rattus norvegicus
<308> P23570
<400> 3669

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
  1               5                  10                  15
Asn Ser Asn Gln Ile Pro Gly Leu Ser Trp Ile Asn Lys Glu Glu Met 
             20                  25                  30
Ile Phe Gln Ile Pro Trp Lys His Ala Ala Leu His Gly Trp Asp Ile 
         35                  40                  45
Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg 
     50                  55                  60
Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn 
 65                  70                  75                  80
Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                 85                  90                  95
Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu 
             100                105                110
Pro Pro Leu Thr Lys Asn Gln Arg Lys Glu Arg Lys Ser Lys Ser Ser 
         115                120                125
Arg Asp Thr Lys Ser Lys Thr Lys Arg Lys Leu Cys Gly Asp Ser Ser 
     130                135                140
Pro Asp Thr Leu Ser Asp Gly Leu Ser Ser Ser Thr Leu Pro Asp Asp 
 145                150                155                160
His Ser Ser Tyr Thr Ala Gln Gly Tyr Leu Gly Gln Asp Leu Asp Met 
                 165                170                175
Asp Arg Asp Ile Thr Pro Ala Leu Ser Pro Cys Val Val Ser Ser Ser 
             180                185                190
Leu Ser Glu Trp His Met Gln Met Asp Ile Met Pro Asp Ser Thr Thr 
         195                200                205
Asp Leu Tyr Asn Leu Gln Val Ser Pro Met Pro Ser Thr Ser Glu Ala 
     210                215                220
Ala Thr Asp Glu Asp Glu Glu Gly Lys Leu Pro Glu Asp Ile Met Lys 
 225                230                235                240
Leu Phe Glu Gln Ser Glu Trp Gln Pro Thr His Val Asp Gly Lys Gly 
                 245                250                255
Tyr Leu Leu Asn Glu Pro Gly Ala Gln Leu Ser Thr Val Tyr Gly Asp 
             260                265                270
Phe Ser Cys Lys Glu Glu Pro Glu Ile Asp Ser Pro Gly Gly Asp Ile 
         275                280                285
Glu Ile Gly Ile Gln Arg Val Phe Thr Glu Met Lys Asn Met Asp Pro 
     290                295                300
Val Met Trp Met Asp Thr Leu Leu Gly Asn Ser Thr Arg Pro Pro Ser 
 305                310                315                320
Ile Gln Ala Ile Pro Cys Ala Pro 
                 325



<210> 3670
<211> 2035
<212> DNA
<213> Homo sapiens
<308> X14454
<400> 3670

cgagccccg  cgaaccgag  ccacccgga  ccgtgccca  tccacgccg  ccgtgcccg  60
cggccttaa  aaccaggca  cctctgcct  cttccctct  ccactcgga  tcgcgctcc  120
cgcgccctc  ctgcagccc  tgcgtcgcc  ggaccctcg  gcgcgacca  ccgaatcgc  180
cctgcagca  agccaacat  cccatcact  ggatgcgca  gagaccctg  ctagagatg  240
agattaatt  caaccaaat  ccggggctc  tctggatta  taaagagga  atgatcttc  300
agatcccat  gaagcatgc  gccaagcat  gctgggaca  caacaagga  gcctgtttg  360
tccggagct  ggccattca  acaggccga  acaaagcag  ggaaaagga  ccagatccc  420
agacgtgga  ggccaactt  cgctgtgcc  tgaactccc  gccagatat  gaggaggtg  480
aagaccaga  caggaacaa  ggcagctca  ctgtgcgag  gtaccggat  cttccacct  540
tcaccaaga  ccagagaaa  gaaagaaag  cgaagtcca  ccgagatgc  aagagcaag  600
ccaagagga  gtcatgtgg  gattccagc  ctgatacct  ctctgatgg  ctcagcagc  660
ccactctgc  tgatgacca  agcagctac  cagttccag  ctacatgca  gacttggag  720
tggagcagg  cctgactcc  gcactgtcg  catgtgctg  cagcagcac  ctccccgac  780
ggcacatcc  agtggaagt  gtgccggac  gcaccagtg  tctgtacaa  ttccaggtg  840
cacccatgc  ctccacctc  gaagctaca  cagatgagg  tgaggaagg  aaattacct  900
aggacatca  gaagctctt  gagcagtcg  agtggcagc  aacaaacgt  gatgggaag  960
ggtacctac  caatgaacc  ggagtccag  ccacctctg  ctatggaga  tttagctgt  1020
aggaggagc  agaaattga  agcccaggg  gggatattg  gctgagtct  cagcgtgtc  1080
tcacagatc  gaagaacat  gatgccacc  ggctggaca  cctgctgac  ccagtccgg  1140
tgccctcca  ccaggccat  ccctgtgca  cgtagcagg  cccctgggc  cctcttatt  1200
ctctaggca  gcaggacct  gcatcatgg  ggatatggt  cagagaagc  ggacttctg  1260
gggcccctc  acagccaag  gtgacccca  tgccaagtg  ggatgggcc  ccctccttg  1320
gtcattgac  tctcagggc  tggcaggcc  gtgtctggg  ttttcttgt  gtgtaaagc  1380
ggccctgcc  cctgggaag  tgaggttct  agaccagtg  atcaggtca  ggacttgga  1440
aggagtcag  gtctggctt  ttcctctga  cccagctgc  tggagaggg  ctcgctgtc  1500
ctggctggc  cctagggga  cagaccagt  accccagaa  agcataaca  caatcccag  1560
gctggctct  cactaagcg  aaattgcac  aaatgaatc  cgttccaaa  aactacccc  1620
tttcagctg  gccctgggg  ctgttccaa  gccagtgaa  gtgaaggaa  ctcccctcc  1680
tcggggcaa  gctccctca  cctcagagg  gctctaccc  gctccctgc  ttggctgag  1740
ggcttggga  aaaaacttg  cactttttc  tgtggatct  gccacattt  tgatcagag  1800
tgtacacta  catttcccc  gagctcttg  cctttgcat  tatttatac  gtgccttgc  1860
cggggccca  caccccctc  agccccagc  gccctcaac  ggcccaggg  gggaagtgt  1920
agcgccttg  tatgactta  aattggaaa  gtcatctaa  cattaagtc  tgtgtgaac  1980
cataaggac  tgtgtaaat  tgtacattt  tctttttat  aaaagtaaa  ttgtt  2035



<210> 3671
<211> 325
<212> PRT
<213> Homo sapiens
<308> P10914
<400> 3671

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
  1               5                  10                  15
Asn Ser Asn Gln Ile Pro Gly Leu Ile Trp Ile Asn Lys Glu Glu Met 
             20                  25                  30
Ile Phe Gln Ile Pro Trp Lys His Ala Ala Lys His Gly Trp Asp Ile 
         35                  40                  45
Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg 
     50                  55                  60
Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn 
 65                  70                  75                  80
Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                 85                  90                  95
Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu 
             100                105                110
Pro Pro Leu Thr Lys Asn Gln Arg Lys Glu Arg Lys Ser Lys Ser Ser 
         115                120                125
Arg Asp Ala Lys Ser Lys Ala Lys Arg Lys Ser Cys Gly Asp Ser Ser 
     130                135                140
Pro Asp Thr Phe Ser Asp Gly Leu Ser Ser Ser Thr Leu Pro Asp Asp 
 145                150                155                160
His Ser Ser Tyr Thr Val Pro Gly Tyr Met Gln Asp Leu Glu Val Glu 
                 165                170                175
Gln Ala Leu Thr Pro Ala Leu Ser Pro Cys Ala Val Ser Ser Thr Leu 
             180                185                190
Pro Asp Trp His Ile Pro Val Glu Val Val Pro Asp Ser Thr Ser Asp 
         195                200                205
Leu Tyr Asn Phe Gln Val Ser Pro Met Pro Ser Thr Ser Glu Ala Thr 
     210                215                220
Thr Asp Glu Asp Glu Glu Gly Lys Leu Pro Glu Asp Ile Met Lys Leu 
 225                230                235                240
Leu Glu Gln Ser Glu Trp Gln Pro Thr Asn Val Asp Gly Lys Gly Tyr 
                 245                250                255
Leu Leu Asn Glu Pro Gly Val Gln Pro Thr Ser Val Tyr Gly Asp Phe 
             260                265                270
Ser Cys Lys Glu Glu Pro Glu Ile Asp Ser Pro Gly Gly Asp Ile Gly 
         275                280                285
Leu Ser Leu Gln Arg Val Phe Thr Asp Leu Lys Asn Met Asp Ala Thr 
     290                295                300
Trp Leu Asp Ser Leu Leu Thr Pro Val Arg Leu Pro Ser Ile Gln Ala 
 305                310                315                320
Ile Pro Cys Ala Pro 
                 325



<210> 3672
<211> 1595
<212> DNA
<213> Rattus norvegicus
<308> M35270
<400> 3672

aggacaaac  tcgatcagg  tcaaattga  aataaaagg  ctggagcaa  caacaggga  60
tcaccaacc  ggcctcgcc  ctgagttca  cccagagct  gctgggaaa  gttccggat  120
ttggccaag  ccagtgtga  gctgggctc  agggcagca  gttgggtac  gaacatggg  180
tcgcaccag  tgctggtgc  acccccaga  gccctgagc  agcccctgt  aattcctaa  240
aggctcctg  tgggtccgg  accctccaa  ctggctcct  gtgtgctag  agctggaag  300
ctgaggatg  ttggccaca  gcaaaaaga  atgtttcag  tcatggatg  gatcaagca  360
ggcatccag  atgtgttcc  gaccaggaa  cccctcaca  tggttgtca  cggctcagg  420
cattgtgcc  tggagactg  cctgttcaa  ctcctggag  ctggggact  ctttcttgt  480
ggaaccaat  gcatctggg  gatacgggc  gcagagatc  ctgagcgga  tggagcccg  540
gtgcaccag  tgatcaaga  gcctggaga  cattacaca  tgcaggagg  ggaggaggg  600
ctggctcag  ataaaccag  gttgctgtt  ctgacccac  gggagtcat  cactggtgt  660
ctgcagccc  tggatggtt  cggggagct  tgccacagg  atcagtgcc  actcctggt  720
gactcggtg  catcattgg  cggagtccc  atctacatg  accaacaag  catcgacat  780
ttgtactct  gctctcaga  ggtcctgaa  gccccacca  ggatctccc  catctcctt  840
aacgacaag  ccaaatcca  agtctactc  cggaagaca  agccagtct  cttctacac  900
gacatcact  atttgtcca  gttgtgggg  tgtgagggc  agaccagag  aattcatca  960
acgttgcct  tcatcagct  atactgcct  agggagagc  tagcactca  ttcagagca  1020
ggcctggag  attcctggc  gcgtcacag  gaggctaca  cacatctgc  caagtgcct  1080
cgggagttg  gcttaaagt  ctttgtgaa  gacccggaa  tccggctac  tacaatcac  1140
accgtgacc  tgcctgccg  ctacaactg  agggacatc  tcagctacg  gctggacca  1200
ttcaacatt  aaatctctg  tggtcttgg  ccctctgag  ataaggtgc  gcggattgg  1260
ctcctgggc  acaacgcca  cacagagaa  gcggaccgt  tagcggagg  cctgaggga  1320
gccctgcaa  attgtccta  gaataaatt  tgagcatcg  ctcaccaga  tgtgccctc  1380
tggaggggc  gggaatata  caggaacga  aagactgtg  aagccctcc  gccagcaaa  1440
gctgccgat  taaccaggc  ggaagggtc  gggcgaagc  gcccctctc  ccacagatg  1500
agccctgtg  tcacatgat  ctaatcacc  tccgatgaa  ctgcattct  caggccact  1560
gacttcggg  atattcaat  aagtacttg  cagac  1595



<210> 3673
<211> 414
<212> PRT
<213> Rattus norvegicus
<308> P09139
<400> 3673

Met Phe Arg Met Leu Ala Lys Ala Ser Val Thr Leu Gly Ser Arg Ala 
  1               5                  10                  15
Ala Ser Trp Val Arg Asn Met Gly Ser His Gln Leu Leu Val Pro Pro 
             20                  25                  30
Pro Glu Ala Leu Ser Lys Pro Leu Ser Ile Pro Lys Arg Leu Leu Leu 
         35                  40                  45
Gly Pro Gly Pro Ser Asn Leu Ala Pro Arg Val Leu Ala Ala Gly Ser 
     50                  55                  60
Leu Arg Met Ile Gly His Met Gln Lys Glu Met Phe Gln Ile Met Asp 
 65                  70                  75                  80
Glu Ile Lys Gln Gly Ile Gln Tyr Val Phe Gln Thr Arg Asn Pro Leu 
                 85                  90                  95
Thr Leu Val Val Ser Gly Ser Gly His Cys Ala Met Glu Thr Ala Leu 
             100                105                110
Phe Asn Leu Leu Glu Pro Gly Asp Ser Phe Leu Val Gly Thr Asn Gly 
         115                120                125
Ile Trp Gly Ile Arg Ala Ala Glu Ile Ala Glu Arg Ile Gly Ala Arg 
     130                135                140
Val His Gln Met Ile Lys Lys Pro Gly Glu His Tyr Thr Leu Gln Glu 
 145                150                155                160
Val Glu Glu Gly Leu Ala Gln His Lys Pro Val Leu Leu Phe Leu Thr 
                 165                170                175
His Gly Glu Ser Ser Thr Gly Val Leu Gln Pro Leu Asp Gly Phe Gly 
             180                185                190
Glu Leu Cys His Arg Tyr Gln Cys Leu Leu Leu Val Asp Ser Val Ala 
         195                200                205
Ser Leu Gly Gly Val Pro Ile Tyr Met Asp Gln Gln Gly Ile Asp Ile 
     210                215                220
Leu Tyr Ser Gly Ser Gln Lys Val Leu Asn Ala Pro Pro Gly Ile Ser 
 225                230                235                240
Leu Ile Ser Phe Asn Asp Lys Ala Lys Ser Lys Val Tyr Ser Arg Lys 
                 245                250                255
Thr Lys Pro Val Ser Phe Tyr Thr Asp Ile Thr Tyr Leu Ser Lys Leu 
             260                265                270
Trp Gly Cys Glu Gly Lys Thr Arg Val Ile His His Thr Leu Pro Val 
         275                280                285
Ile Ser Leu Tyr Cys Leu Arg Glu Ser Leu Ala Leu Ile Ser Glu Gln 
     290                295                300
Gly Leu Glu Asn Ser Trp Arg Arg His Arg Glu Ala Thr Ala His Leu 
 305                310                315                320
His Lys Cys Leu Arg Glu Leu Gly Leu Lys Phe Phe Val Lys Asp Pro 
                 325                330                335
Glu Ile Arg Leu Pro Thr Ile Thr Thr Val Thr Val Pro Ala Gly Tyr 
             340                345                350
Asn Trp Arg Asp Ile Val Ser Tyr Val Leu Asp His Phe Asn Ile Glu 
         355                360                365
Ile Ser Gly Gly Leu Gly Pro Ser Glu Asp Lys Val Leu Arg Ile Gly 
     370                375                380
Leu Leu Gly Tyr Asn Ala Thr Thr Glu Asn Ala Asp Arg Val Ala Glu 
 385                390                395                400
Ala Leu Arg Glu Ala Leu Gln His Cys Pro Lys Asn Lys Leu 
                 405                410



<210> 3674
<211> 1600
<212> DNA
<213> Homo sapiens
<308> NM_000030
<400> 3674

ccggaagcc  atccaccaa  cctcacctc  cacctctgt  tccgccctg  tgggaaata  60
tccaggctt  ggccaaggc  agtgcagcc  caggttccc  agcggcagg  tgggtgcgg  120
ccatggcct  tcacaagct  ctggtgacc  cccccaagg  cctgctcaa  cccctctcc  180
tccccaacc  gctcctgct  gggcctggt  cttccaacc  gcctcctcg  atcatggca  240
ccggggggc  gcagatgat  gggtccatg  gcaaggata  gtaccagat  atggacgag  300
tcaaggaag  catccagta  gtgttccag  ccaggaacc  actcacact  gtcatctct  360
gctcgggac  ctgtgccct  gaggccgcc  tggtcaatg  gctggagcc  ggggactcc  420
tcctggttg  ggccaatgg  atttggggg  agcgagccg  ggacatcgg  gagcgcata  480
gagcccgag  gcacccgat  accaaggac  ctggaggcc  ctacacact  caggaggtg  540
aggagggcc  ggcccagca  aagccagtg  tgctgttct  aacccacgg  gagtcgtcc  600
ccggcgtgc  gcagcccct  gatggcttc  gggaactct  ccacaggta  aagtgcctg  660
tcctggtgg  ttcggtggc  tccctgggc  ggacccccc  ttacatgga  cggcaaggc  720
tcgacatcc  gtactcggg  tcccagaag  ccctgaacg  ccctccagg  acctcgctc  780
tctccttca  tgacaaggc  aaaaagaag  tgtactccc  caagacgaa  cccttctcc  840
tctacctgg  catcaagtg  ctggccaac  tctggggct  tgacgacca  cccaggatg  900
accatcaca  aatccccgt  atcagcctg  acagcctga  agagagcct  gccctcatt  960
cggaacagg  cctggagaa  agctggcgc  agcaccgcg  ggccgcggc  tatctgcat  1020
ggcgcctgc  ggcactggg  ctgcagctc  tcgtgaagg  cccggcgct  cggcttccc  1080
cagtcacca  tgtggctgt  cccgctggc  atgactgga  agacatcgt  agctacgtc  1140
tagaccact  cgacattga  atcatgggt  gccttgggc  ctccacggg  aaggtgctg  1200
ggatcggcc  gctgggctg  aatgccacc  gcgagaatg  ggaccgcgt  acggaggcc  1260
tgagggcgg  cctgcagca  tgccccaag  agaagctgt  acctgccca  tggcacaca  1320
ctggcactg  cacacacct  tcccatgcc  accctgagg  atcaggagc  aacagaccc  1380
gcaaggtcc  ccaggcctg  ggacaggaa  gccactgac  cagcccggg  ggcagaacc  1440
ggcagcctc  ctggcccca  gcagccctt  tccctccag  ggcacctcc  ggaaacagt  1500
cacttgggc  caaaaccca  tgccttcca  atgagctgc  gtccccagg  catgagcct  1560
ccgggaatg  ttaataaag  gcctggcca  ctctcctcac  1600



<210> 3675
<211> 392
<212> PRT
<213> Homo sapiens
<308> P21549
<400> 3675

Met Ala Ser His Lys Leu Leu Val Thr Pro Pro Lys Ala Leu Leu Lys 
  1               5                  10                  15
Pro Leu Ser Ile Pro Asn Gln Leu Leu Leu Gly Pro Gly Pro Ser Asn 
             20                  25                  30
Leu Pro Pro Arg Ile Met Ala Ala Gly Gly Leu Gln Met Ile Gly Ser 
         35                  40                  45
Met Ser Lys Asp Met Tyr Gln Ile Met Asp Glu Ile Lys Glu Gly Ile 
     50                  55                  60
Gln Tyr Val Phe Gln Thr Arg Asn Pro Leu Thr Leu Val Ile Ser Gly 
 65                  70                  75                  80
Ser Gly His Cys Ala Leu Glu Ala Ala Leu Val Asn Val Leu Glu Pro 
                 85                  90                  95
Gly Asp Ser Phe Leu Val Gly Ala Asn Gly Ile Trp Gly Gln Arg Ala 
             100                105                110
Val Asp Ile Gly Glu Arg Ile Gly Ala Arg Val His Pro Met Thr Lys 
         115                120                125
Asp Pro Gly Gly His Tyr Thr Leu Gln Glu Val Glu Glu Gly Leu Ala 
     130                135                140
Gln His Lys Pro Val Leu Leu Phe Leu Thr His Gly Glu Ser Ser Thr 
 145                150                155                160
Gly Val Leu Gln Pro Leu Asp Gly Phe Gly Glu Leu Cys His Arg Tyr 
                 165                170                175
Lys Cys Leu Leu Leu Val Asp Ser Val Ala Ser Leu Gly Gly Thr Pro 
             180                185                190
Leu Tyr Met Asp Arg Gln Gly Ile Asp Ile Leu Tyr Ser Gly Ser Gln 
         195                200                205
Lys Ala Leu Asn Ala Pro Pro Gly Thr Ser Leu Ile Ser Phe Ser Asp 
     210                215                220
Lys Ala Lys Lys Lys Met Tyr Ser Arg Lys Thr Lys Pro Phe Ser Phe 
 225                230                235                240
Tyr Leu Asp Ile Lys Trp Leu Ala Asn Phe Trp Gly Cys Asp Asp Gln 
                 245                250                255
Pro Arg Met Tyr His His Thr Ile Pro Val Ile Ser Leu Tyr Ser Leu 
             260                265                270
Arg Glu Ser Leu Ala Leu Ile Ala Glu Gln Gly Leu Glu Asn Ser Trp 
         275                280                285
Arg Gln His Arg Glu Ala Ala Ala Tyr Leu His Gly Arg Leu Gln Ala 
     290                295                300
Leu Gly Leu Gln Leu Phe Val Lys Asp Pro Ala Leu Arg Leu Pro Thr 
 305                310                315                320
Val Thr Thr Val Ala Val Pro Ala Gly Tyr Asp Trp Arg Asp Ile Val 
                 325                330                335
Ser Tyr Val Ile Asp His Phe Asp Ile Glu Ile Met Gly Gly Leu Gly 
             340                345                350
Pro Ser Thr Gly Lys Val Leu Arg Ile Gly Leu Leu Gly Cys Asn Ala 
         355                360                365
Thr Arg Glu Asn Val Asp Arg Val Thr Glu Ala Leu Arg Ala Ala Leu 
     370                375                380
Gln His Cys Pro Lys Lys Lys Leu 
 385                390



<210> 3676
<211> 1595
<212> DNA
<213> Rattus norvegicus
<308> M35270
<400> 3676

aggacaaac  tcgatcagg  tcaaattga  aataaaagg  ctggagcaa  caacaggga  60
tcaccaacc  ggcctcgcc  ctgagttca  cccagagct  gctgggaaa  gttccggat  120
ttggccaag  ccagtgtga  gctgggctc  agggcagca  gttgggtac  gaacatggg  180
tcgcaccag  tgctggtgc  acccccaga  gccctgagc  agcccctgt  aattcctaa  240
aggctcctg  tgggtccgg  accctccaa  ctggctcct  gtgtgctag  agctggaag  300
ctgaggatg  ttggccaca  gcaaaaaga  atgtttcag  tcatggatg  gatcaagca  360
ggcatccag  atgtgttcc  gaccaggaa  cccctcaca  tggttgtca  cggctcagg  420
cattgtgcc  tggagactg  cctgttcaa  ctcctggag  ctggggact  ctttcttgt  480
ggaaccaat  gcatctggg  gatacgggc  gcagagatc  ctgagcgga  tggagcccg  540
gtgcaccag  tgatcaaga  gcctggaga  cattacaca  tgcaggagg  ggaggaggg  600
ctggctcag  ataaaccag  gttgctgtt  ctgacccac  gggagtcat  cactggtgt  660
ctgcagccc  tggatggtt  cggggagct  tgccacagg  atcagtgcc  actcctggt  720
gactcggtg  catcattgg  cggagtccc  atctacatg  accaacaag  catcgacat  780
ttgtactct  gctctcaga  ggtcctgaa  gccccacca  ggatctccc  catctcctt  840
aacgacaag  ccaaatcca  agtctactc  cggaagaca  agccagtct  cttctacac  900
gacatcact  atttgtcca  gttgtgggg  tgtgagggc  agaccagag  aattcatca  960
acgttgcct  tcatcagct  atactgcct  agggagagc  tagcactca  ttcagagca  1020
ggcctggag  attcctggc  gcgtcacag  gaggctaca  cacatctgc  caagtgcct  1080
cgggagttg  gcttaaagt  ctttgtgaa  gacccggaa  tccggctac  tacaatcac  1140
accgtgacc  tgcctgccg  ctacaactg  agggacatc  tcagctacg  gctggacca  1200
ttcaacatt  aaatctctg  tggtcttgg  ccctctgag  ataaggtgc  gcggattgg  1260
ctcctgggc  acaacgcca  cacagagaa  gcggaccgt  tagcggagg  cctgaggga  1320
gccctgcaa  attgtccta  gaataaatt  tgagcatcg  ctcaccaga  tgtgccctc  1380
tggaggggc  gggaatata  caggaacga  aagactgtg  aagccctcc  gccagcaaa  1440
gctgccgat  taaccaggc  ggaagggtc  gggcgaagc  gcccctctc  ccacagatg  1500
agccctgtg  tcacatgat  ctaatcacc  tccgatgaa  ctgcattct  caggccact  1560
gacttcggg  atattcaat  aagtacttg  cagac  1595



<210> 3677
<211> 414
<212> PRT
<213> Rattus norvegicus
<308> P09139
<400> 3677

Met Phe Arg Met Leu Ala Lys Ala Ser Val Thr Leu Gly Ser Arg Ala 
  1               5                  10                  15
Ala Ser Trp Val Arg Asn Met Gly Ser His Gln Leu Leu Val Pro Pro 
             20                  25                  30
Pro Glu Ala Leu Ser Lys Pro Leu Ser Ile Pro Lys Arg Leu Leu Leu 
         35                  40                  45
Gly Pro Gly Pro Ser Asn Leu Ala Pro Arg Val Leu Ala Ala Gly Ser 
     50                  55                  60
Leu Arg Met Ile Gly His Met Gln Lys Glu Met Phe Gln Ile Met Asp 
 65                  70                  75                  80
Glu Ile Lys Gln Gly Ile Gln Tyr Val Phe Gln Thr Arg Asn Pro Leu 
                 85                  90                  95
Thr Leu Val Val Ser Gly Ser Gly His Cys Ala Met Glu Thr Ala Leu 
             100                105                110
Phe Asn Leu Leu Glu Pro Gly Asp Ser Phe Leu Val Gly Thr Asn Gly 
         115                120                125
Ile Trp Gly Ile Arg Ala Ala Glu Ile Ala Glu Arg Ile Gly Ala Arg 
     130                135                140
Val His Gln Met Ile Lys Lys Pro Gly Glu His Tyr Thr Leu Gln Glu 
 145                150                155                160
Val Glu Glu Gly Leu Ala Gln His Lys Pro Val Leu Leu Phe Leu Thr 
                 165                170                175
His Gly Glu Ser Ser Thr Gly Val Leu Gln Pro Leu Asp Gly Phe Gly 
             180                185                190
Glu Leu Cys His Arg Tyr Gln Cys Leu Leu Leu Val Asp Ser Val Ala 
         195                200                205
Ser Leu Gly Gly Val Pro Ile Tyr Met Asp Gln Gln Gly Ile Asp Ile 
     210                215                220
Leu Tyr Ser Gly Ser Gln Lys Val Leu Asn Ala Pro Pro Gly Ile Ser 
 225                230                235                240
Leu Ile Ser Phe Asn Asp Lys Ala Lys Ser Lys Val Tyr Ser Arg Lys 
                 245                250                255
Thr Lys Pro Val Ser Phe Tyr Thr Asp Ile Thr Tyr Leu Ser Lys Leu 
             260                265                270
Trp Gly Cys Glu Gly Lys Thr Arg Val Ile His His Thr Leu Pro Val 
         275                280                285
Ile Ser Leu Tyr Cys Leu Arg Glu Ser Leu Ala Leu Ile Ser Glu Gln 
     290                295                300
Gly Leu Glu Asn Ser Trp Arg Arg His Arg Glu Ala Thr Ala His Leu 
 305                310                315                320
His Lys Cys Leu Arg Glu Leu Gly Leu Lys Phe Phe Val Lys Asp Pro 
                 325                330                335
Glu Ile Arg Leu Pro Thr Ile Thr Thr Val Thr Val Pro Ala Gly Tyr 
             340                345                350
Asn Trp Arg Asp Ile Val Ser Tyr Val Leu Asp His Phe Asn Ile Glu 
         355                360                365
Ile Ser Gly Gly Leu Gly Pro Ser Glu Asp Lys Val Leu Arg Ile Gly 
     370                375                380
Leu Leu Gly Tyr Asn Ala Thr Thr Glu Asn Ala Asp Arg Val Ala Glu 
 385                390                395                400
Ala Leu Arg Glu Ala Leu Gln His Cys Pro Lys Asn Lys Leu 
                 405                410



<210> 3678
<211> 1600
<212> DNA
<213> Homo sapiens
<308> NM_000030
<400> 3678

ccggaagcc  atccaccaa  cctcacctc  cacctctgt  tccgccctg  tgggaaata  60
tccaggctt  ggccaaggc  agtgcagcc  caggttccc  agcggcagg  tgggtgcgg  120
ccatggcct  tcacaagct  ctggtgacc  cccccaagg  cctgctcaa  cccctctcc  180
tccccaacc  gctcctgct  gggcctggt  cttccaacc  gcctcctcg  atcatggca  240
ccggggggc  gcagatgat  gggtccatg  gcaaggata  gtaccagat  atggacgag  300
tcaaggaag  catccagta  gtgttccag  ccaggaacc  actcacact  gtcatctct  360
gctcgggac  ctgtgccct  gaggccgcc  tggtcaatg  gctggagcc  ggggactcc  420
tcctggttg  ggccaatgg  atttggggg  agcgagccg  ggacatcgg  gagcgcata  480
gagcccgag  gcacccgat  accaaggac  ctggaggcc  ctacacact  caggaggtg  540
aggagggcc  ggcccagca  aagccagtg  tgctgttct  aacccacgg  gagtcgtcc  600
ccggcgtgc  gcagcccct  gatggcttc  gggaactct  ccacaggta  aagtgcctg  660
tcctggtgg  ttcggtggc  tccctgggc  ggacccccc  ttacatgga  cggcaaggc  720
tcgacatcc  gtactcggg  tcccagaag  ccctgaacg  ccctccagg  acctcgctc  780
tctccttca  tgacaaggc  aaaaagaag  tgtactccc  caagacgaa  cccttctcc  840
tctacctgg  catcaagtg  ctggccaac  tctggggct  tgacgacca  cccaggatg  900
accatcaca  aatccccgt  atcagcctg  acagcctga  agagagcct  gccctcatt  960
cggaacagg  cctggagaa  agctggcgc  agcaccgcg  ggccgcggc  tatctgcat  1020
ggcgcctgc  ggcactggg  ctgcagctc  tcgtgaagg  cccggcgct  cggcttccc  1080
cagtcacca  tgtggctgt  cccgctggc  atgactgga  agacatcgt  agctacgtc  1140
tagaccact  cgacattga  atcatgggt  gccttgggc  ctccacggg  aaggtgctg  1200
ggatcggcc  gctgggctg  aatgccacc  gcgagaatg  ggaccgcgt  acggaggcc  1260
tgagggcgg  cctgcagca  tgccccaag  agaagctgt  acctgccca  tggcacaca  1320
ctggcactg  cacacacct  tcccatgcc  accctgagg  atcaggagc  aacagaccc  1380
gcaaggtcc  ccaggcctg  ggacaggaa  gccactgac  cagcccggg  ggcagaacc  1440
ggcagcctc  ctggcccca  gcagccctt  tccctccag  ggcacctcc  ggaaacagt  1500
cacttgggc  caaaaccca  tgccttcca  atgagctgc  gtccccagg  catgagcct  1560
ccgggaatg  ttaataaag  gcctggcca  ctctcctcac  1600



<210> 3679
<211> 392
<212> PRT
<213> Homo sapiens
<308> P21549
<400> 3679

Met Ala Ser His Lys Leu Leu Val Thr Pro Pro Lys Ala Leu Leu Lys 
  1               5                  10                  15
Pro Leu Ser Ile Pro Asn Gln Leu Leu Leu Gly Pro Gly Pro Ser Asn 
             20                  25                  30
Leu Pro Pro Arg Ile Met Ala Ala Gly Gly Leu Gln Met Ile Gly Ser 
         35                  40                  45
Met Ser Lys Asp Met Tyr Gln Ile Met Asp Glu Ile Lys Glu Gly Ile 
     50                  55                  60
Gln Tyr Val Phe Gln Thr Arg Asn Pro Leu Thr Leu Val Ile Ser Gly 
 65                  70                  75                  80
Ser Gly His Cys Ala Leu Glu Ala Ala Leu Val Asn Val Leu Glu Pro 
                 85                  90                  95
Gly Asp Ser Phe Leu Val Gly Ala Asn Gly Ile Trp Gly Gln Arg Ala 
             100                105                110
Val Asp Ile Gly Glu Arg Ile Gly Ala Arg Val His Pro Met Thr Lys 
         115                120                125
Asp Pro Gly Gly His Tyr Thr Leu Gln Glu Val Glu Glu Gly Leu Ala 
     130                135                140
Gln His Lys Pro Val Leu Leu Phe Leu Thr His Gly Glu Ser Ser Thr 
 145                150                155                160
Gly Val Leu Gln Pro Leu Asp Gly Phe Gly Glu Leu Cys His Arg Tyr 
                 165                170                175
Lys Cys Leu Leu Leu Val Asp Ser Val Ala Ser Leu Gly Gly Thr Pro 
             180                185                190
Leu Tyr Met Asp Arg Gln Gly Ile Asp Ile Leu Tyr Ser Gly Ser Gln 
         195                200                205
Lys Ala Leu Asn Ala Pro Pro Gly Thr Ser Leu Ile Ser Phe Ser Asp 
     210                215                220
Lys Ala Lys Lys Lys Met Tyr Ser Arg Lys Thr Lys Pro Phe Ser Phe 
 225                230                235                240
Tyr Leu Asp Ile Lys Trp Leu Ala Asn Phe Trp Gly Cys Asp Asp Gln 
                 245                250                255
Pro Arg Met Tyr His His Thr Ile Pro Val Ile Ser Leu Tyr Ser Leu 
             260                265                270
Arg Glu Ser Leu Ala Leu Ile Ala Glu Gln Gly Leu Glu Asn Ser Trp 
         275                280                285
Arg Gln His Arg Glu Ala Ala Ala Tyr Leu His Gly Arg Leu Gln Ala 
     290                295                300
Leu Gly Leu Gln Leu Phe Val Lys Asp Pro Ala Leu Arg Leu Pro Thr 
 305                310                315                320
Val Thr Thr Val Ala Val Pro Ala Gly Tyr Asp Trp Arg Asp Ile Val 
                 325                330                335
Ser Tyr Val Ile Asp His Phe Asp Ile Glu Ile Met Gly Gly Leu Gly 
             340                345                350
Pro Ser Thr Gly Lys Val Leu Arg Ile Gly Leu Leu Gly Cys Asn Ala 
         355                360                365
Thr Arg Glu Asn Val Asp Arg Val Thr Glu Ala Leu Arg Ala Ala Leu 
     370                375                380
Gln His Cys Pro Lys Lys Lys Leu 
 385                390



<210> 3680
<211> 562
<212> DNA
<213> Rattus norvegicus
<308> M36151
<400> 3680

agagactcc  caagggatt  cgtgtacca  ttcgagggc  agtgctact  caccaccgg  60
acgcagcgc  tgcggctcg  gaccagaca  atctacaac  gggaggagt  cgtgcgctt  120
gacagcgac  tgggcgagt  ccgcgcgct  accgagctg  ggcggccct  agccgagta  180
tggaataag  agtacctcg  gcagacgcg  gccgagctg  acagggtct  cagatacaa  240
tacgagggg  cgggggctc  cacctccct  agacggctt  agcagccca  tgtggccat  300
tccctgtcc  ggacagagg  ccttaacca  cacaacctg  tggtctgct  agtgacaga  360
ttctaccca  cccagatca  agtgcgctg  ttccggaat  gccaggagg  gacgacggg  420
gtcgtgtcc  cacagctta  taggaatgg  gactggacc  tccagatcc  ggtcatgct  480
gagatcacg  ctcagcggg  agatgtgta  acctgccat  ttgaccacc  cagccttca  540
agccctgtc  cagtggagt  gc  562



<210> 3681
<211> 187
<212> PRT
<213> Rattus norvegicus
<308> AAA41612
<400> 3681

Arg Asp Ser Pro Arg Asp Phe Val Tyr Gln Phe Glu Gly Gln Cys Tyr 
  1               5                  10                  15
Tyr Thr Thr Gly Thr Gln Arg Met Arg Leu Val Thr Arg His Ile Tyr 
             20                  25                  30
Asn Arg Glu Glu Tyr Val Arg Phe Asp Ser Asp Leu Gly Glu Tyr Arg 
         35                  40                  45
Ala Leu Thr Glu Leu Gly Arg Pro Ser Ala Glu Tyr Trp Asn Lys Gln 
     50                  55                  60
Tyr Leu Glu Gln Thr Arg Ala Glu Leu Asp Arg Val Cys Arg Tyr Asn 
 65                  70                  75                  80
Tyr Glu Gly Pro Gly Ala Leu Thr Ser Leu Arg Arg Leu Glu Gln Pro 
                 85                  90                  95
Asn Val Ala Ile Ser Leu Ser Arg Thr Glu Ala Leu Asn His His Asn 
             100                105                110
Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val 
         115                120                125
Arg Trp Phe Arg Asn Gly Gln Glu Glu Thr Thr Gly Val Val Ser Thr 
     130                135                140
Gln Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu 
 145                150                155                160
Glu Ile Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Asp His 
                 165                170                175
Pro Ser Leu Gln Ser Pro Val Thr Val Glu Trp 
             180                185



<210> 3682
<211> 1171
<212> DNA
<213> Homo sapiens
<308> M81141
<400> 3682

ctgtgttga  taccacttt  cccttcgtc  caattatgt  ttggaaaaa  gctttgcgg  60
tccccggag  ccttcgggc  gcaactgtg  ccttgatgc  gtcgatgct  agcacccca  120
tggctgagg  cagagactc  cccgaggat  tcgtgtacc  gtttaaggg  atgtgctac  180
tcaccaacg  gacagagcg  gtgcgtctt  tgagcagaa  catctataa  cgagaagag  240
tcgtgcgct  cgacagcga  gtgggggag  tccgggcgg  gaccgtgct  gggctgcct  300
ccgccgagt  ctggaacag  cagaaggac  tcctggaga  gaaacgggc  gcggtggac  360
gggtgtgca  acacaacta  cagttggag  tccgcacga  cttgcagcg  cgagtggag  420
ccacagtga  catctcccc  tccaggaca  aggccctca  ccaccacaa  ctgctggtc  480
gctcggtga  agatttcta  ccagcccag  tcaaagtcc  gtggtttcg  aatggccag  540
aggagacag  tggcgttgt  tccaccccc  ttattagga  tggtgactg  accttccag  600
tcctggtga  gctggaaat  actccccag  gtggagacg  ctacacctg  cacgtggag  660
accccagcc  ccagagccc  atcaccgtg  agtggcggg  tcaatctga  tctgcccag  720
gcaagatgc  gagtggcat  ggaggcttc  tgctggggc  gatcttcct  gggctgggc  780
ttatcatcc  tcacaggag  cagaaaggg  tcctgcact  actcctgag  ctattttaa  840
tgggattgg  tatcacttt  ctgtaacgc  tgcttgtcc  tgcccagaa  tcccagctg  900
ctgtgtcag  ctgtccccc  gagatcaga  tcctacagt  gctgtcacg  agccaccag  960
tcatctcct  tcatcccca  cttgaggcg  atggctgtg  ccctacttc  tgcactgac  1020
cacagcccc  gcctgtgca  agccagctg  atctactca  gccccaagg  gtttctgtt  1080
ctattctct  ctcagactg  tcaagagaa  cacatgaaa  ctattacct  actttagag  1140
ttttttaca  aattaaaca  gatcctgag  t  1171



<210> 3683
<211> 261
<212> PRT
<213> Homo sapiens
<308> P01919
<400> 3683

Met Ser Trp Lys Lys Ser Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
  1               5                  10                  15
Thr Val Thr Leu Met Leu Ala Ile Leu Ser Ser Ser Leu Ala Glu Gly 
             20                  25                  30
Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Leu Cys Tyr 
         35                  40                  45
Phe Thr Asn Gly Thr Glu Arg Val Arg Gly Val Thr Arg His Ile Tyr 
     50                  55                  60
Asn Arg Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
 65                  70                  75                  80
Ala Val Thr Pro Gln Gly Arg Pro Val Ala Glu Tyr Trp Asn Ser Gln 
                 85                  90                  95
Lys Glu Val Leu Glu Gly Ala Arg Ala Ser Val Asp Arg Val Cys Arg 
             100                105                110
His Asn Tyr Glu Val Ala Tyr Arg Gly Ile Leu Gln Arg Arg Val Glu 
         115                120                125
Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
     130                135                140
Asn Leu Leu Ile Cys Ser Val Thr Asp Phe Tyr Pro Ser Gln Ile Lys 
 145                150                155                160
Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                 165                170                175
Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
             180                185                190
Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
         195                200                205
His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
     210                215                220
Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu 
 225                230                235                240
Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Arg 
                 245                250                255
Lys Gly Leu Leu His 
             260



<210> 3684
<211> 1157
<212> DNA
<213> Rattus norvegicus
<308> M36410
<400> 3684

ggcaggcta  gttgcgctg  ctgcgtgct  accggggct  cccggggct  cggccgcgc  60
ctggccccg  agctggccg  gttgctgtc  cccggttcg  tgttgcttc  aagcgcacg  120
agtgactcg  tgctgcggc  actgaagga  gagctctgt  cgcagcagc  gggcctgca  180
gtggtgctg  cagccgccg  tttgggcac  gagtccggc  tgcaacagt  gctgagcgc  240
gtgcgcgag  tccctaggc  cgagaggct  cagcgcctc  tgctcatca  caatgcagg  300
actcttggg  atgtttcca  aggcttcct  aacatcaat  acctagctg  ggtgaacaa  360
tactgggcc  tgaacctaa  ctccatgct  tgcttgacc  ccggcacct  gaatgcctt  420
tccaatagc  ctggcctga  caagactgt  gttaacatc  catctctgt  tgccctgca  480
cctttcaag  gctggggac  ctactgtgc  gggaaggct  cccgagaca  gttatacca  540
gtcctggct  ttgaggaac  cagtgtgag  gtgctgagc  atgccccag  tcccctgga  600
accaacatg  agcagttgg  ccgggaaac  tccatggac  cagagttga  gagcagact  660
cagaagttg  attctgagg  ggagctggt  gactgtggg  cttcagccc  gaaactgct  720
agcttgctg  aaagggaca  cttccaatc  ggagcccac  tggacttct  tgacattta  780
gcccatgtc  tgtcacagc  ccccccccc  ccagccctg  ctaacacac  tacaagccc  840
ccaacccag  cagcgggag  cacgggcac  gccagtcct  agaaggctt  tgcagaggc  900
cgggagaga  ctgatgtgt  ctggagtcc  ctgtcccca  gaagagaac  tagggctgg  960
agagcagga  aagcagaaa  actgagcag  tgaggcaga  tctctcgtc  gtggtcgtt  1020
tcaggtgaa  agggcgggg  ctgattcac  gagaggacc  agggtattg  atctttgtt  1080
tactgcctt  atcctgggg  attcactgg  cctccctcg  ctctggtca  atacatggt  1140
atggcagat  ccctaga  1157



<210> 3685
<211> 262
<212> PRT
<213> Rattus norvegicus
<308> P18297
<400> 3685

Met Glu Gly Gly Arg Leu Gly Cys Ala Val Cys Val Leu Thr Gly Ala 
  1               5                  10                  15
Ser Arg Gly Phe Gly Arg Ala Leu Ala Pro Gln Leu Ala Gly Leu Leu 
             20                  25                  30
Ser Pro Gly Ser Val Leu Leu Leu Ser Ala Arg Ser Asp Ser Met Leu 
         35                  40                  45
Arg Gln Leu Lys Glu Glu Leu Cys Thr Gln Gln Pro Gly Leu Gln Val 
     50                  55                  60
Val Leu Ala Ala Ala Asp Leu Gly Thr Glu Ser Gly Val Gln Gln Leu 
 65                  70                  75                  80
Leu Ser Ala Val Arg Glu Leu Pro Arg Pro Glu Arg Leu Gln Arg Leu 
                 85                  90                  95
Leu Leu Ile Asn Asn Ala Gly Thr Leu Gly Asp Val Ser Lys Gly Phe 
             100                105                110
Leu Asn Ile Asn Asp Leu Ala Glu Val Asn Asn Tyr Trp Ala Leu Asn 
         115                120                125
Leu Thr Ser Met Leu Cys Leu Thr Thr Gly Thr Leu Asn Ala Phe Ser 
     130                135                140
Asn Ser Pro Gly Leu Ser Lys Thr Val Val Asn Ile Ser Ser Leu Cys 
 145                150                155                160
Ala Leu Gln Pro Phe Lys Gly Trp Gly Leu Tyr Cys Ala Gly Lys Ala 
                 165                170                175
Ala Arg Asp Met Leu Tyr Gln Val Leu Ala Val Glu Glu Pro Ser Val 
             180                185                190
Arg Val Leu Ser Tyr Ala Pro Gly Pro Leu Asp Thr Asn Met Gln Gln 
         195                200                205
Leu Ala Arg Glu Thr Ser Met Asp Pro Glu Leu Arg Ser Arg Leu Gln 
     210                215                220
Lys Leu Asn Ser Glu Gly Glu Leu Val Asp Cys Gly Thr Ser Ala Gln 
 225                230                235                240
Lys Leu Leu Ser Leu Leu Gln Arg Asp Thr Phe Gln Ser Gly Ala His 
                 245                250                255
Val Asp Phe Tyr Asp Ile 
             260



<210> 3686
<211> 833
<212> DNA
<213> Homo sapiens
<308> M76231
<400> 3686

gccgccggc  gagaacagg  gcatggagg  cgggctggg  cgtgctgtg  gcttgctga  60
cggggcctc  cgcggcttc  gccggacgc  ggccccgct  ctggcctcg  tgctgtcgc  120
cggctccgt  cttgtcctt  gcgcccgca  cgacgaggc  ctgcgccag  tggaggccg  180
gctgggcgc  gagcggtct  gcctgcgcg  ggtgcgggt  cccgccgac  tgggcgccg  240
ggccggctt  cagcagctg  tcggcgccc  gcgcgagct  ccccggccc  aggggctgc  300
gcgactgct  cttatcaac  acgcgggct  tcttgggga  gtgtccaaa  gcttcgtgg  360
cctgagtga  tccactcaa  tgaacaact  ctgggcact  aacttgacc  ccatgctct  420
cctgacttc  agcgtcctg  aggccttcc  ggacagtcc  ggcctcaac  gaaccgtgg  480
taacatctc  tccctctgt  ccctgcaac  tttcaaagg  tgggcgctg  actgtgcag  540
aaaggctgc  cgtgatatg  tgttccagg  cctggcgct  gaggaacct  atgtgaggg  600
gctgaacta  gccccaggt  ctctggaca  agacatgca  cagttggcc  gggagacct  660
cgtggaccc  gacatgcga  aagggctgc  ggagctgaa  gcaaagggg  agctggtgg  720
ttgcaaggt  tcagcccag  aactgctga  cttactgga  aaggacgag  tcaagtctg  780
agcccacgt  gacttctat  acaaataag  ccatgtttt  ggcttcctg  acc  833



<210> 3687
<211> 261
<212> PRT
<213> Homo sapiens
<308> P35270
<400> 3687

Met Glu Gly Gly Leu Gly Arg Ala Val Cys Leu Leu Thr Gly Ala Ser 
  1               5                  10                  15
Arg Gly Phe Gly Arg Thr Leu Ala Pro Leu Leu Ala Ser Leu Leu Ser 
             20                  25                  30
Pro Gly Ser Val Leu Val Leu Ser Ala Arg Asn Asp Glu Ala Leu Arg 
         35                  40                  45
Gln Leu Glu Ala Glu Leu Gly Ala Glu Arg Ser Gly Leu Arg Val Val 
     50                  55                  60
Arg Val Pro Ala Asp Leu Gly Ala Glu Ala Gly Leu Gln Gln Leu Leu 
 65                  70                  75                  80
Gly Ala Leu Arg Glu Leu Pro Arg Pro Lys Gly Leu Gln Arg Leu Leu 
                 85                  90                  95
Leu Ile Asn Asn Ala Gly Ser Leu Gly Asp Val Ser Lys Gly Phe Val 
             100                105                110
Asp Leu Ser Asp Ser Thr Gln Val Asn Asn Tyr Trp Ala Leu Asn Leu 
         115                120                125
Thr Ser Met Leu Cys Leu Thr Ser Ser Val Leu Lys Ala Phe Pro Asp 
     130                135                140
Ser Pro Gly Leu Asn Arg Thr Val Val Asn Ile Ser Ser Leu Cys Ala 
 145                150                155                160
Leu Gln Pro Phe Lys Gly Trp Ala Leu Tyr Cys Ala Gly Lys Ala Ala 
                 165                170                175
Arg Asp Met Leu Phe Gln Val Leu Ala Leu Glu Glu Pro Asn Val Arg 
             180                185                190
Val Leu Asn Tyr Ala Pro Gly Pro Leu Asp Thr Asp Met Gln Gln Leu 
         195                200                205
Ala Arg Glu Thr Ser Val Asp Pro Asp Met Arg Lys Gly Leu Gln Glu 
     210                215                220
Leu Lys Ala Lys Gly Lys Leu Val Asp Cys Lys Val Ser Ala Gln Lys 
 225                230                235                240
Leu Leu Ser Leu Leu Glu Lys Asp Glu Phe Lys Ser Gly Ala His Val 
                 245                250                255
Asp Phe Tyr Asp Lys 
             260



<210> 3688
<211> 1157
<212> DNA
<213> Rattus norvegicus
<308> M36410
<400> 3688

ggcaggcta  gttgcgctg  ctgcgtgct  accggggct  cccggggct  cggccgcgc  60
ctggccccg  agctggccg  gttgctgtc  cccggttcg  tgttgcttc  aagcgcacg  120
agtgactcg  tgctgcggc  actgaagga  gagctctgt  cgcagcagc  gggcctgca  180
gtggtgctg  cagccgccg  tttgggcac  gagtccggc  tgcaacagt  gctgagcgc  240
gtgcgcgag  tccctaggc  cgagaggct  cagcgcctc  tgctcatca  caatgcagg  300
actcttggg  atgtttcca  aggcttcct  aacatcaat  acctagctg  ggtgaacaa  360
tactgggcc  tgaacctaa  ctccatgct  tgcttgacc  ccggcacct  gaatgcctt  420
tccaatagc  ctggcctga  caagactgt  gttaacatc  catctctgt  tgccctgca  480
cctttcaag  gctggggac  ctactgtgc  gggaaggct  cccgagaca  gttatacca  540
gtcctggct  ttgaggaac  cagtgtgag  gtgctgagc  atgccccag  tcccctgga  600
accaacatg  agcagttgg  ccgggaaac  tccatggac  cagagttga  gagcagact  660
cagaagttg  attctgagg  ggagctggt  gactgtggg  cttcagccc  gaaactgct  720
agcttgctg  aaagggaca  cttccaatc  ggagcccac  tggacttct  tgacattta  780
gcccatgtc  tgtcacagc  ccccccccc  ccagccctg  ctaacacac  tacaagccc  840
ccaacccag  cagcgggag  cacgggcac  gccagtcct  agaaggctt  tgcagaggc  900
cgggagaga  ctgatgtgt  ctggagtcc  ctgtcccca  gaagagaac  tagggctgg  960
agagcagga  aagcagaaa  actgagcag  tgaggcaga  tctctcgtc  gtggtcgtt  1020
tcaggtgaa  agggcgggg  ctgattcac  gagaggacc  agggtattg  atctttgtt  1080
tactgcctt  atcctgggg  attcactgg  cctccctcg  ctctggtca  atacatggt  1140
atggcagat  ccctaga  1157



<210> 3689
<211> 262
<212> PRT
<213> Rattus norvegicus
<308> P18297
<400> 3689

Met Glu Gly Gly Arg Leu Gly Cys Ala Val Cys Val Leu Thr Gly Ala 
  1               5                  10                  15
Ser Arg Gly Phe Gly Arg Ala Leu Ala Pro Gln Leu Ala Gly Leu Leu 
             20                  25                  30
Ser Pro Gly Ser Val Leu Leu Leu Ser Ala Arg Ser Asp Ser Met Leu 
         35                  40                  45
Arg Gln Leu Lys Glu Glu Leu Cys Thr Gln Gln Pro Gly Leu Gln Val 
     50                  55                  60
Val Leu Ala Ala Ala Asp Leu Gly Thr Glu Ser Gly Val Gln Gln Leu 
 65                  70                  75                  80
Leu Ser Ala Val Arg Glu Leu Pro Arg Pro Glu Arg Leu Gln Arg Leu 
                 85                  90                  95
Leu Leu Ile Asn Asn Ala Gly Thr Leu Gly Asp Val Ser Lys Gly Phe 
             100                105                110
Leu Asn Ile Asn Asp Leu Ala Glu Val Asn Asn Tyr Trp Ala Leu Asn 
         115                120                125
Leu Thr Ser Met Leu Cys Leu Thr Thr Gly Thr Leu Asn Ala Phe Ser 
     130                135                140
Asn Ser Pro Gly Leu Ser Lys Thr Val Val Asn Ile Ser Ser Leu Cys 
 145                150                155                160
Ala Leu Gln Pro Phe Lys Gly Trp Gly Leu Tyr Cys Ala Gly Lys Ala 
                 165                170                175
Ala Arg Asp Met Leu Tyr Gln Val Leu Ala Val Glu Glu Pro Ser Val 
             180                185                190
Arg Val Leu Ser Tyr Ala Pro Gly Pro Leu Asp Thr Asn Met Gln Gln 
         195                200                205
Leu Ala Arg Glu Thr Ser Met Asp Pro Glu Leu Arg Ser Arg Leu Gln 
     210                215                220
Lys Leu Asn Ser Glu Gly Glu Leu Val Asp Cys Gly Thr Ser Ala Gln 
 225                230                235                240
Lys Leu Leu Ser Leu Leu Gln Arg Asp Thr Phe Gln Ser Gly Ala His 
                 245                250                255
Val Asp Phe Tyr Asp Ile 
             260



<210> 3690
<211> 833
<212> DNA
<213> Homo sapiens
<308> M76231
<400> 3690

gccgccggc  gagaacagg  gcatggagg  cgggctggg  cgtgctgtg  gcttgctga  60
cggggcctc  cgcggcttc  gccggacgc  ggccccgct  ctggcctcg  tgctgtcgc  120
cggctccgt  cttgtcctt  gcgcccgca  cgacgaggc  ctgcgccag  tggaggccg  180
gctgggcgc  gagcggtct  gcctgcgcg  ggtgcgggt  cccgccgac  tgggcgccg  240
ggccggctt  cagcagctg  tcggcgccc  gcgcgagct  ccccggccc  aggggctgc  300
gcgactgct  cttatcaac  acgcgggct  tcttgggga  gtgtccaaa  gcttcgtgg  360
cctgagtga  tccactcaa  tgaacaact  ctgggcact  aacttgacc  ccatgctct  420
cctgacttc  agcgtcctg  aggccttcc  ggacagtcc  ggcctcaac  gaaccgtgg  480
taacatctc  tccctctgt  ccctgcaac  tttcaaagg  tgggcgctg  actgtgcag  540
aaaggctgc  cgtgatatg  tgttccagg  cctggcgct  gaggaacct  atgtgaggg  600
gctgaacta  gccccaggt  ctctggaca  agacatgca  cagttggcc  gggagacct  660
cgtggaccc  gacatgcga  aagggctgc  ggagctgaa  gcaaagggg  agctggtgg  720
ttgcaaggt  tcagcccag  aactgctga  cttactgga  aaggacgag  tcaagtctg  780
agcccacgt  gacttctat  acaaataag  ccatgtttt  ggcttcctg  acc  833



<210> 3691
<211> 261
<212> PRT
<213> Homo sapiens
<308> P35270
<400> 3691

Met Glu Gly Gly Leu Gly Arg Ala Val Cys Leu Leu Thr Gly Ala Ser 
  1               5                  10                  15
Arg Gly Phe Gly Arg Thr Leu Ala Pro Leu Leu Ala Ser Leu Leu Ser 
             20                  25                  30
Pro Gly Ser Val Leu Val Leu Ser Ala Arg Asn Asp Glu Ala Leu Arg 
         35                  40                  45
Gln Leu Glu Ala Glu Leu Gly Ala Glu Arg Ser Gly Leu Arg Val Val 
     50                  55                  60
Arg Val Pro Ala Asp Leu Gly Ala Glu Ala Gly Leu Gln Gln Leu Leu 
 65                  70                  75                  80
Gly Ala Leu Arg Glu Leu Pro Arg Pro Lys Gly Leu Gln Arg Leu Leu 
                 85                  90                  95
Leu Ile Asn Asn Ala Gly Ser Leu Gly Asp Val Ser Lys Gly Phe Val 
             100                105                110
Asp Leu Ser Asp Ser Thr Gln Val Asn Asn Tyr Trp Ala Leu Asn Leu 
         115                120                125
Thr Ser Met Leu Cys Leu Thr Ser Ser Val Leu Lys Ala Phe Pro Asp 
     130                135                140
Ser Pro Gly Leu Asn Arg Thr Val Val Asn Ile Ser Ser Leu Cys Ala 
 145                150                155                160
Leu Gln Pro Phe Lys Gly Trp Ala Leu Tyr Cys Ala Gly Lys Ala Ala 
                 165                170                175
Arg Asp Met Leu Phe Gln Val Leu Ala Leu Glu Glu Pro Asn Val Arg 
             180                185                190
Val Leu Asn Tyr Ala Pro Gly Pro Leu Asp Thr Asp Met Gln Gln Leu 
         195                200                205
Ala Arg Glu Thr Ser Val Asp Pro Asp Met Arg Lys Gly Leu Gln Glu 
     210                215                220
Leu Lys Ala Lys Gly Lys Leu Val Asp Cys Lys Val Ser Ala Gln Lys 
 225                230                235                240
Leu Leu Ser Leu Leu Glu Lys Asp Glu Phe Lys Ser Gly Ala His Val 
                 245                250                255
Asp Phe Tyr Asp Lys 
             260



<210> 3692
<211> 3641
<212> DNA
<213> Rattus norvegicus
<308> M55015
<400> 3692

ggatccaat  tgatatggt  atatccaat  ataatttgt  taagcacca  atatgtatt  60
ggtgtttgt  gactccact  caacacaaa  tgtactagc  gtccctgct  ctgctgcac  120
caaacttgt  cctaagtta  ggccttgtg  gcacctacc  ttgagccac  ttcctcact  180
cagttagca  aatttccaa  ctattatat  ccaggcaat  gcttaggta  caagaataa  240
caatccgtg  tctgtctgg  taaggggca  attaacaat  aacgcccaa  tactaggca  300
ctgataata  ctaacagtg  aacctaggg  cacaagagt  agtctctta  tggcacttt  360
caccagagg  ctgaggaaa  cccaacaga  tgaattgac  aagagaagt  atgtcattt  420
acactcaga  ctcatcttc  ctcctcccg  atgccttta  cttgctctg  ttggaaata  480
ccaggtctt  ctcacacca  ccttcctat  cctctaccc  agagtctcc  ttggctcca  540
actatacag  tgaaggtgt  accggtctc  ctttaaaga  aatgccccc  cacaacact  600
gtccgcatc  cctgccctg  ctagagagc  cttgtgtgt  gctgtggct  ccctccacc  660
tgttgggaa  gccttagga  gtaagcatc  cgcagtgac  atttctact  atctccaaa  720
gcccgtgtt  agatagaaa  cccggggtc  caacacatc  cacttgagt  aaaatctcc  780
gaggatggc  aaggagggg  caggggtat  tccgagttc  aaggcagcc  ggtctagaa  840
gagtcccgg  gcagccagg  ctacaaaga  aaaacctat  tcaaaaact  caatcaagg  900
gttggggat  tagctcagc  gtagagcgc  tgcctagca  gcgcaaggc  ctgggttcg  960
tccccagct  cgaaaaaag  accaaaaaa  aaaaaactc  aatcaaatc  tctagattg  1020
gccgggcgt  acgacgcgg  cgaggctag  ctggtctac  cagtgtgct  taccacggc  1080
agagcaaat  gtgaggccc  atctcaacc  ccaccagca  ctccacagg  aatttttaa  1140
cgatattgt  agctgatga  ggcacccgt  tgctacgct  ggaaccagt  agtggcaat  1200
cgtttaaag  aatccaaga  aactctctc  tcctctgcc  cggagggaa  tcgtgagcg  1260
tcccaggca  gccgagtac  tctcccacc  cacaccagg  agtcacctc  ctgaacctg  1320
agttatacc  accgcgtga  gtcagagat  aaatggact  tttgtgcac  gctcacaca  1380
acacacacg  gcgcgcgcg  gcgaaattg  ttttattag  agctctcag  aaagtggtg  1440
ctcgcatca  gctaccaca  ccaagagga  cgccacctc  accgagggc  ggccaaggc  1500
cactaaacg  cccgaatga  ctctaggcc  tccggcgct  tccagctct  cagcgcggc  1560
aacgttcta  gcccctgag  agtccaccg  gaggcgcag  tttccgcta  gcgaggggg  1620
aatccccga  aaatgccca  accacctaa  cacagacgt  catgcggcg  acggatacc  1680
gagggaatc  gggccatac  gccacctac  cgcgcctca  tcaagccgc  ccaaactcg  1740
gcgtttcac  gcgcaggcg  gtacgcagc  ggcgctcag  aacactcaa  ggaccagca  1800
actgaccaa  caacgtccg  cttggccaa  actagtccc  ccctcaaaa  cagacgtca  1860
gccccgccc  taagagccc  gccctcccc  acgctttag  cccgaccca  gccgtcctg  1920
gttaaggct  gcggttggt  cgggggacg  acgcgagct  tggttggtg  aggtgaggt  1980
acgagaaca  cttcgtcgc  tttccagag  cgattactg  gcaagctca  tcttttgcc  2040
cagacgcta  ctgtagctg  caggcggtt  tacgtgctc  agagtcttc  ttacccgcc  2100
atccagtcg  cttcgcgtg  gttccgcta  gctcttctg  gctgctcgc  ctctacaca  2160
gccgtcgcc  taatccgcc  tcatggtga  actcgcaaa  gtaataggc  tgacgcgcg  2220
acacggacg  ctaggcctg  tttctgaga  acgcgcgcg  gcccgtcgc  gaggggagg  2280
gggcctgcg  acagtcccg  gcgcgttcg  gggcgcatg  tgagggaag  ctcgcgcga  2340
tagcggaag  gtctcgcgg  gtttggcct  tgacttgag  gatgagagg  gccgaggca  2400
gttctggga  ggcgatgta  agtgcaccg  ggccggggg  cggtgtgag  ggaagtcgg  2460
ggagttgag  gcggagagg  ggttggagg  tcggcgagt  aagtgggcc  accttaagc  2520
gctaccgct  tcgggggcc  ccgcctccc  gcgcacgtg  tccggtgcg  ggcccgcca  2580
gtggttacg  cgctccgca  gtgtcgcgc  tccgaggca  tgaggggag  gggagtaca  2640
gggaaaggg  gacagtaga  ttgggccat  ttacctagc  atcgcatgt  cctgaccgt  2700
acggtagat  gacacgtgg  gggctcctg  ggtagcgcg  ggtgacccg  cctaggtga  2760
tccacgtgg  ttggctgta  gcgtgagaa  gtaggaagt  gctccgata  agagatgct  2820
ttaagaggt  ccttcgaga  aaccccctt  cccggcaaa  agttaaaat  gaaccttta  2880
ctgggtttt  ttctttttt  tggaaggtg  cagaaaata  agtgccacg  ctaagtaga  2940
tttaaaaac  tgtggctgt  tcctggtga  ggtttctgt  tgtaagaca  attatgcgc  3000
gttctcaga  aaatttgcc  ggaagagtg  gctgcctgg  cacgagaag  ctttatgct  3060
gtgttcttt  gtaagaaag  aggtggtgg  cgaggacaa  gtggcttac  atgcgggtg  3120
tttttttgt  tgcatttgt  ggccggcaa  acccacgga  agtccaaga  aatggctcc  3180
cctccaaag  aggtggaag  agatagtga  gatgaagaa  tgtcagaag  tgaagatga  3240
agcagtgga  aagaggagg  aggatgcta  ttgaaaaat  gtgtgattt  cagtggtag  3300
ttgactgga  gtgtcagaa  taacagtca  ttcgggggg  gtctgggca  agttttgta  3360
gttgtattg  gtagagttt  ctgtagatt  gtggggtgg  tttccctcc  tttttggga  3420
aattgctta  tctagccta  tttttattc  gtccatggt  acttggctt  gtgaatttt  3480
gcaggacat  atgacagga  gctgtagac  agcctaacc  cagataggt  ctcctgaat  3540
aggtgttag  cacagtatc  acgacaaat  acaagttta  tgagaaacc  agactttga  3600
ctaggtaga  atggaatca  ggtctcagc  taggtggta  c  3641



<210> 3693
<211> 712
<212> PRT
<213> Rattus norvegicus
<308> AAA41732
<400> 3693

Val Lys Leu Ala Lys Ala Gly Lys Thr His Gly Glu Ser Lys Lys Met 
  1               5                  10                  15
Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu Met 
             20                  25                  30
Ser Glu Asp Glu Asp Asp Ser Ser Gly Glu Glu Glu Val Val Ile Pro 
         35                  40                  45
Gln Lys Lys Gly Lys Lys Ala Thr Thr Thr Pro Ala Lys Lys Val Val 
     50                  55                  60
Val Ser Gln Thr Lys Lys Ala Ala Val Pro Thr Pro Ala Lys Lys Ala 
 65                  70                  75                  80
Ala Val Thr Pro Gly Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys Ala 
                 85                  90                  95
Val Thr Pro Ala Lys Val Val Pro Thr Pro Gly Lys Lys Gly Ala Ala 
             100                105                110
Gln Ala Lys Ala Leu Val Pro Thr Pro Gly Lys Lys Gly Ala Val Thr 
         115                120                125
Pro Ala Lys Gly Ala Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp Ser 
     130                135                140
Asp Glu Asp Glu Asp Glu Glu Asp Glu Asp Asp Ser Asp Glu Asp Glu 
 145                150                155                160
Asp Glu Glu Asp Glu Phe Glu Pro Pro Val Val Lys Gly Val Lys Pro 
                 165                170                175
Ala Lys Ala Ala Pro Ala Ala Pro Ala Ser Glu Asp Glu Asp Glu Glu 
             180                185                190
Asp Asp Asp Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Glu Glu Glu 
         195                200                205
Glu Asp Asp Ser Glu Glu Glu Val Met Glu Ile Thr Pro Ala Lys Gly 
     210                215                220
Lys Lys Thr Pro Ala Lys Val Val Pro Val Lys Ala Lys Ser Val Ala 
 225                230                235                240
Glu Glu Glu Glu Asp Asp Glu Asp Asp Glu Asp Glu Glu Glu Asp Glu 
                 245                250                255
Asp Glu Glu Asp Glu Glu Asp Asp Glu Asp Glu Asp Glu Glu Glu Glu 
             260                265                270
Glu Glu Pro Val Lys Ala Ala Pro Gly Lys Arg Lys Lys Glu Met Thr 
         275                280                285
Lys Gln Lys Glu Ala Pro Glu Ala Lys Lys Gln Lys Ile Glu Gly Ser 
     290                295                300
Glu Pro Thr Thr Pro Phe Asn Leu Phe Ile Gly Asn Leu Asn Pro Asn 
 305                310                315                320
Lys Ser Val Ala Glu Leu Lys Val Ala Ile Ser Glu Leu Phe Ala Lys 
                 325                330                335
Asn Asp Leu Ala Ala Val Asp Val Arg Thr Gly Thr Asn Arg Lys Phe 
             340                345                350
Gly Tyr Val Asp Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala Leu Glu 
         355                360                365
Leu Thr Gly Leu Lys Val Phe Gly Asn Glu Ile Lys Leu Glu Lys Pro 
     370                375                380
Lys Gly Arg Asp Ser Lys Lys Val Arg Ala Ala Arg Thr Leu Leu Ala 
 385                390                395                400
Lys Asn Leu Ser Phe Asn Ile Thr Glu Asp Glu Leu Lys Glu Val Phe 
                 405                410                415
Glu Asp Ala Val Glu Ile Arg Leu Val Ser Gln Asp Gly Arg Ser Lys 
             420                425                430
Gly Ile Ala Tyr Ile Glu Phe Lys Ser Glu Ala Asp Ala Glu Lys Asn 
         435                440                445
Leu Glu Glu Lys Gln Gly Ala Glu Ile Asp Gly Arg Ser Val Ser Leu 
     450                455                460
Tyr Tyr Thr Gly Glu Lys Gly Gln Arg Gln Glu Arg Thr Gly Lys Asn 
 465                470                475                480
Ser Thr Trp Ser Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser 
                 485                490                495
Tyr Ser Ala Thr Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr 
             500                505                510
Phe Ile Lys Val Pro Gln Asn Pro His Gly Lys Ser Lys Gly Tyr Ala 
         515                520                525
Phe Ile Glu Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser 
     530                535                540
Cys Asn Lys Met Glu Ile Glu Gly Arg Thr Ile Arg Leu Glu Leu Gln 
 545                550                555                560
Gly Pro Arg Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu 
                 565                570                575
Phe Val Lys Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu 
             580                585                590
Ser Phe Glu Gly Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr 
         595                600                605
Gly Ser Ser Lys Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp 
     610                615                620
Ala Lys Ala Ala Lys Glu Ala Met Glu Asp Gly Glu Ile Asp Gly Asn 
 625                630                635                640
Lys Val Thr Leu Asp Trp Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly 
                 645                650                655
Gly Arg Gly Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg 
             660                665                670
Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly 
         675                680                685
Arg Gly Gly Phe Arg Gly Gly Arg Gly Gly Gly Gly Asp Phe Lys Pro 
     690                695                700
Gln Gly Lys Lys Thr Lys Phe Glu 
 705                710



<210> 3694
<211> 896
<212> DNA
<213> Rattus norvegicus
<308> M55017
<400> 3694

ttatgtgtg  gagtgcatt  agcatgctt  gtcccctca  gctagaata  aatgtactt  60
gtatacctg  aactggtat  acagctaca  gtggatgtt  aacttgtta  aagagtaac  120
agtggggct  gggatttat  tagctcagt  gtagtgcgc  tacctagga  gcgcaaggc  180
ctgggttcg  tccccagct  cgaaaaaaa  aaagagtaa  aagtgctct  aacttctga  240
ccatctctc  agttcttta  tttttagaa  catatctaa  gtctatctt  tgttagtaa  300
ttaacatag  attggatat  gaggaatgc  tatgatttg  ttgctttca  ggttgtcat  360
cctcagaag  aaggcaaaa  ggctaccac  actccagca  agaaggtgg  tgtttcaca  420
acaaaaaag  ctgcagttc  cacaccagc  aagaaagca  ctgttaccc  aggcaaaaa  480
gcagcagcc  caccagcca  gaaagctgt  acaccagcc  aagtagttc  aacacctgg  540
aaaaaggga  ctgcacaag  aaaagcatt  gtaccaact  ctggtaaaa  gggagctgt  600
actccagcc  agggggcta  gaatggtaa  aatgccaag  aggaagaca  cgatgagga  660
gaagatgaa  aggatgaag  tgacagcga  gaggatgaa  atgaagagg  tgaatttga  720
ccaccggta  taaaaggag  gaaaccagc  aaagcagct  ctgctgctc  tgcctcaga  780
gatgaggat  aggaagatg  tgatgatga  gatgatgat  atgatgatg  agaggagga  840
gaggaagat  gtgagttag  gcttaggat  ttgagtact  catgtacac  cctgca  896



<210> 3695
<211> 712
<212> PRT
<213> Rattus norvegicus
<308> AAA41732
<400> 3695

Val Lys Leu Ala Lys Ala Gly Lys Thr His Gly Glu Ser Lys Lys Met 
  1               5                  10                  15
Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu Met 
             20                  25                  30
Ser Glu Asp Glu Asp Asp Ser Ser Gly Glu Glu Glu Val Val Ile Pro 
         35                  40                  45
Gln Lys Lys Gly Lys Lys Ala Thr Thr Thr Pro Ala Lys Lys Val Val 
     50                  55                  60
Val Ser Gln Thr Lys Lys Ala Ala Val Pro Thr Pro Ala Lys Lys Ala 
 65                  70                  75                  80
Ala Val Thr Pro Gly Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys Ala 
                 85                  90                  95
Val Thr Pro Ala Lys Val Val Pro Thr Pro Gly Lys Lys Gly Ala Ala 
             100                105                110
Gln Ala Lys Ala Leu Val Pro Thr Pro Gly Lys Lys Gly Ala Val Thr 
         115                120                125
Pro Ala Lys Gly Ala Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp Ser 
     130                135                140
Asp Glu Asp Glu Asp Glu Glu Asp Glu Asp Asp Ser Asp Glu Asp Glu 
 145                150                155                160
Asp Glu Glu Asp Glu Phe Glu Pro Pro Val Val Lys Gly Val Lys Pro 
                 165                170                175
Ala Lys Ala Ala Pro Ala Ala Pro Ala Ser Glu Asp Glu Asp Glu Glu 
             180                185                190
Asp Asp Asp Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Glu Glu Glu 
         195                200                205
Glu Asp Asp Ser Glu Glu Glu Val Met Glu Ile Thr Pro Ala Lys Gly 
     210                215                220
Lys Lys Thr Pro Ala Lys Val Val Pro Val Lys Ala Lys Ser Val Ala 
 225                230                235                240
Glu Glu Glu Glu Asp Asp Glu Asp Asp Glu Asp Glu Glu Glu Asp Glu 
                 245                250                255
Asp Glu Glu Asp Glu Glu Asp Asp Glu Asp Glu Asp Glu Glu Glu Glu 
             260                265                270
Glu Glu Pro Val Lys Ala Ala Pro Gly Lys Arg Lys Lys Glu Met Thr 
         275                280                285
Lys Gln Lys Glu Ala Pro Glu Ala Lys Lys Gln Lys Ile Glu Gly Ser 
     290                295                300
Glu Pro Thr Thr Pro Phe Asn Leu Phe Ile Gly Asn Leu Asn Pro Asn 
 305                310                315                320
Lys Ser Val Ala Glu Leu Lys Val Ala Ile Ser Glu Leu Phe Ala Lys 
                 325                330                335
Asn Asp Leu Ala Ala Val Asp Val Arg Thr Gly Thr Asn Arg Lys Phe 
             340                345                350
Gly Tyr Val Asp Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala Leu Glu 
         355                360                365
Leu Thr Gly Leu Lys Val Phe Gly Asn Glu Ile Lys Leu Glu Lys Pro 
     370                375                380
Lys Gly Arg Asp Ser Lys Lys Val Arg Ala Ala Arg Thr Leu Leu Ala 
 385                390                395                400
Lys Asn Leu Ser Phe Asn Ile Thr Glu Asp Glu Leu Lys Glu Val Phe 
                 405                410                415
Glu Asp Ala Val Glu Ile Arg Leu Val Ser Gln Asp Gly Arg Ser Lys 
             420                425                430
Gly Ile Ala Tyr Ile Glu Phe Lys Ser Glu Ala Asp Ala Glu Lys Asn 
         435                440                445
Leu Glu Glu Lys Gln Gly Ala Glu Ile Asp Gly Arg Ser Val Ser Leu 
     450                455                460
Tyr Tyr Thr Gly Glu Lys Gly Gln Arg Gln Glu Arg Thr Gly Lys Asn 
 465                470                475                480
Ser Thr Trp Ser Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser 
                 485                490                495
Tyr Ser Ala Thr Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr 
             500                505                510
Phe Ile Lys Val Pro Gln Asn Pro His Gly Lys Ser Lys Gly Tyr Ala 
         515                520                525
Phe Ile Glu Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser 
     530                535                540
Cys Asn Lys Met Glu Ile Glu Gly Arg Thr Ile Arg Leu Glu Leu Gln 
 545                550                555                560
Gly Pro Arg Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu 
                 565                570                575
Phe Val Lys Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu 
             580                585                590
Ser Phe Glu Gly Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr 
         595                600                605
Gly Ser Ser Lys Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp 
     610                615                620
Ala Lys Ala Ala Lys Glu Ala Met Glu Asp Gly Glu Ile Asp Gly Asn 
 625                630                635                640
Lys Val Thr Leu Asp Trp Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly 
                 645                650                655
Gly Arg Gly Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg 
             660                665                670
Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly 
         675                680                685
Arg Gly Gly Phe Arg Gly Gly Arg Gly Gly Gly Gly Asp Phe Lys Pro 
     690                695                700
Gln Gly Lys Lys Thr Lys Phe Glu 
 705                710



<210> 3696
<211> 2122
<212> DNA
<213> Rattus norvegicus
<308> M55417
<400> 3696

gaattccag  cgacctcag  aaaaccgca  agactgaac  gacacccgc  tcaccggag  60
ggccagcct  atgcgcatt  cacgtcggg  gcagtagtt  tccgttgcg  tccaagaat  120
gagtacacg  gggccccaa  tataagtcc  agagtgcac  gagcttgac  gcctctggg  180
gccacagct  cccagaacg  cttcctgcc  gaatggacc  ataggaggg  tggaactgg  240
agaaaggcg  atggtgggg  gtgacctgg  ggaggaact  aagagagga  acctgggcg  300
gtgcgtagg  aatcccaga  tgagactga  ttgggagaa  gctccaggt  gagagtcac  360
aggaaacac  agagacgac  cccaagaca  agtcatagg  agatccaga  acaagaaag  420
ctcaggtat  gtcagtcat  gggagatat  gagggacga  gccctcaga  atggagagt  480
accgggaga  atggataaa  gagagaccg  cagagatgg  gagccatag  gagagacag  540
agagagaac  cccgagacg  agtcacggg  aggcaaatg  gaaagaaag  gagagagag  600
gagacgact  agaggggac  atacaagga  tcacctagg  agggtcgag  ttcccctga  660
gacagttcc  aggagcaca  cgacaaggg  cgatattcc  ccagagaca  tcattggga  720
acaaggaag  agaagagac  actagagac  gagtcacaa  gaatggaga  gaacccgca  780
aaataaaga  ggtcacagg  ccaaaagga  aaactctga  tgggtcaga  aaaaaagga  840
agaaggaca  ggtgattat  cagagagag  acccccttg  gacagaaaa  ggagaaata  900
agaagcagg  agtgacgga  gtcgggaaa  gctgaatta  taggcaaag  tgaacgcga  960
tagggaaga  cgggaaagg  tggaagatg  aaacgaaaa  atttccagt  caccatgtg  1020
ggcgtgagg  gagacgtga  caagaaaag  aaagaagca  agagggggg  aatggagag  1080
gtaaatagg  gagaagaga  gaaaagaga  acaagagaa  gcagagaaa  agacacacc  1140
agagggagg  atggcacca  gcccagagg  tgtaagagc  ataaagagc  cgaagcatc  1200
cggagaatg  gacattagc  tccgcggtc  tcagaaagt  ctcagcact  aagacaaag  1260
ttcttgatt  aaagagtaa  atgtccaga  acacacagg  cgaccccag  tcctagatt  1320
tggcaagac  cacacaagc  gctgagtcg  ggaggaaga  gggtgtggg  gccaagata  1380
cagactgga  tgtatttgg  agaaagggg  tggacaagg  ttggaggac  tcccctcct  1440
gcatagagc  cgggcaatg  gagtgtgca  gtggagagg  gggaggggc  actgtccgg  1500
attcttggg  gtgggggaa  gcctttaaa  tgaaacccc  ccccttggt  ctcatggca  1560
gcctacccc  acccccgac  tctactttc  gcaggtgcg  tagcgacgt  ccgccgccg  1620
ccgtgcctg  cgtcctaga  gccccagtc  tctactgct  tgaccccac  cgctttctc  1680
cggctcggt  cagctggtg  cggggggtg  tgctttctg  cctgcgctg  gcaccgtta  1740
tgccctgcc  ctgtccttc  gatctcaga  tctgcggag  ggcccctat  gccgtccac  1800
tgtttcctc  gaaaaaagg  cagctcgtg  tccctgctg  gttcctggg  ccatggcgg  1860
tctgggtcc  ggcgggggc  actcagaag  gggaccccg  cccctgttt  gcagaaagg  1920
ggcgctgag  cagaaggtg  tccacgagg  gaagagcca  aagttcacc  ctcgtttct  1980
caagcagcc  accttctgc  gtcactgta  cgacttcat  tggtgaggg  agcgggctg  2040
gagagaggg  cggagaagg  ggggacttg  gaacagtca  gtcacactg  cccccaagc  2100
attgaacag  gaggggctg  ag  2122



<210> 3697
<211> 697
<212> PRT
<213> Rattus norvegicus
<308> NP_036760
<400> 3697

Met Ala Gly Leu Gly Pro Gly Gly Gly Asp Ser Glu Gly Gly Pro Arg 
  1               5                  10                  15
Pro Leu Phe Cys Arg Lys Gly Ala Leu Arg Gln Lys Val Val His Glu 
             20                  25                  30
Val Lys Ser His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr Phe 
         35                  40                  45
Cys Ser His Cys Thr Asp Phe Ile Trp Gly Ile Gly Lys Gln Gly Leu 
     50                  55                  60
Gln Cys Gln Val Cys Ser Phe Val Val His Arg Arg Cys His Glu Phe 
 65                  70                  75                  80
Val Thr Phe Glu Cys Pro Gly Ala Gly Lys Gly Pro Gln Thr Asp Asp 
                 85                  90                  95
Pro Arg Asn Lys His Lys Phe Arg Leu His Ser Tyr Ser Ser Pro Thr 
             100                105                110
Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Val His Gln Gly 
         115                120                125
Met Lys Cys Ser Cys Cys Glu Met Asn Val His Arg Arg Cys Val Arg 
     130                135                140
Ser Val Pro Ser Leu Cys Gly Val Asp His Thr Glu Arg Arg Gly Arg 
 145                150                155                160
Leu Gln Leu Glu Ile Arg Ala Pro Thr Ser Asp Glu Ile His Ile Thr 
                 165                170                175
Val Gly Glu Ala Arg Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
             180                185                190
Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Arg Asn Leu Thr 
         195                200                205
Lys Gln Lys Thr Lys Thr Val Lys Ala Thr Leu Asn Pro Val Trp Asn 
     210                215                220
Glu Thr Phe Val Phe Asn Leu Lys Pro Gly Asp Val Glu Arg Arg Leu 
 225                230                235                240
Ser Val Glu Val Trp Asp Trp Asp Arg Thr Ser Arg Asn Asp Phe Met 
                 245                250                255
Gly Ala Met Ser Phe Gly Val Ser Glu Leu Leu Lys Ala Pro Val Asp 
             260                265                270
Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
         275                280                285
Pro Val Ala Asp Ala Asp Asn Cys Ser Leu Leu Gln Lys Phe Glu Ala 
     290                295                300
Cys Asn Tyr Pro Leu Glu Leu Tyr Glu Arg Val Arg Met Gly Pro Ser 
 305                310                315                320
Ser Ser Pro Ile Pro Ser Pro Ser Pro Ser Pro Thr Asp Ser Lys Arg 
                 325                330                335
Cys Phe Phe Gly Ala Ser Pro Gly Arg Leu His Ile Ser Asp Phe Ser 
             340                345                350
Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys Val Met Leu Ala 
         355                360                365
Glu Arg Arg Gly Ser Asp Glu Leu Tyr Ala Ile Lys Ile Leu Lys Lys 
     370                375                380
Asp Val Ile Val Gln Asp Asp Asp Val Asp Cys Thr Leu Val Glu Lys 
 385                390                395                400
Arg Val Leu Ala Leu Gly Gly Arg Gly Pro Gly Gly Arg Pro His Phe 
                 405                410                415
Leu Thr Gln Leu His Ser Thr Phe Gln Thr Pro Asp Arg Leu Tyr Phe 
             420                425                430
Val Met Glu Tyr Val Thr Gly Gly Asp Leu Met Tyr His Ile Gln Gln 
         435                440                445
Leu Gly Lys Phe Lys Glu Pro His Ala Ala Phe Tyr Ala Ala Glu Ile 
     450                455                460
Ala Ile Gly Leu Phe Phe Leu His Asn Gln Gly Ile Ile Tyr Arg Asp 
 465                470                475                480
Leu Lys Leu Asp Asn Val Met Leu Asp Ala Glu Gly His Ile Lys Ile 
                 485                490                495
Thr Asp Phe Gly Met Cys Lys Glu Asn Val Phe Pro Gly Ser Thr Thr 
             500                505                510
Arg Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala 
         515                520                525
Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ser Phe Gly Val Leu 
     530                535                540
Leu Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu 
 545                550                555                560
Glu Glu Leu Phe Gln Ala Ile Met Glu Gln Thr Val Thr Tyr Pro Lys 
                 565                570                575
Ser Leu Ser Arg Glu Ala Val Ala Ile Cys Lys Gly Phe Leu Thr Lys 
             580                585                590
His Pro Gly Lys Arg Leu Gly Ser Gly Pro Asp Gly Glu Pro Thr Ile 
         595                600                605
Arg Ala His Gly Phe Phe Arg Trp Ile Asp Trp Glu Arg Leu Glu Arg 
     610                615                620
Leu Glu Ile Ala Pro Pro Phe Arg Pro Arg Pro Cys Gly Arg Ser Gly 
 625                630                635                640
Glu Asn Phe Asp Lys Phe Phe Thr Arg Ala Ala Pro Ala Leu Thr Pro 
                 645                650                655
Pro Asp Arg Leu Val Leu Ala Ser Ile Asp Gln Ala Asp Phe Gln Gly 
             660                665                670
Phe Thr Tyr Val Asn Pro Asp Phe Val His Pro Asp Ala Arg Ser Pro 
         675                680                685
Thr Ser Pro Val Pro Val Pro Val Met 
     690                695



<210> 3698
<211> 2506
<212> DNA
<213> Homo sapiens
<308> NM_002739
<400> 3698

ccttgcgga  ccggcgcgc  cggggtgcc  ctccctgcc  ggcgcgctc  gcacctgga  60
gtgccttgc  cctctcctg  ccacctcgg  atttccctg  ggctccttt  atccttcga  120
tctccagct  ctctccctt  cacctgttt  ccccaagaa  ggcaggatc  tggtccctg  180
tacgtttct  gggccatgg  tggtctggg  cccggcgta  gcgattcag  ggggggacc  240
cggcccctg  tctgcagaa  gggggctct  aggcagaag  tggtccacg  agtcaagag  300
cacaagttc  ccgctcgct  cttcaagca  cccaccttc  gcagccact  caccgactt  360
atctggggt  tcggaaagc  gggcctgca  tgtcaagtc  gcagctttg  ggttcatcg  420
cgatgccac  aatttgtga  cttcgagtg  ccaggcgct  ggaagggcc  ccagacgga  480
gacccccgg  acaaacaca  gttccgcct  catagctac  gcagcccca  cttctgcga  540
cactgtggc  ccctcctct  cgggcttgt  caccagggc  tgaaatgtt  ttgctgcga  600
atgaacgtg  accggcgct  tgtgcgtag  gtgccctct  tgtgcggtg  ggaccacac  660
gagcgccgc  ggcgcctgc  gctggagat  cgggctccc  cagcagatg  gatccacgt  720
actgttggc  aggcccgta  cctaattcc  atggacccc  atggtctct  tgatcccta  780
gtgaaactg  agctcatcc  agaccctcg  aacctgacg  aacagaaga  ccgaacggt  840
aaagccacg  taaaccctg  gtggaatga  acctttgtg  tcaacctga  gccagggga  900
gtggagcgc  ggctcagcg  ggaggtgtg  gactgggac  ggacctccc  caacgactt  960
atgggggcc  tgtcctttg  cgtctcgga  ctgctcaag  cgcccgtgg  tggctggta  1020
aagttactg  accaggagg  gggcgagta  tacaatgtg  cggtggccg  tgctgacaa  1080
tgcagcctc  tccagaagt  tgaggcttg  aactacccc  tggaattgt  tgagcgggt  1140
cggatgggc  cctcttcct  tcccatccc  tccccttcc  ctagtccca  cgaccccaa  1200
cgctgcttc  tcggggcga  tccaggacg  ctgcacatc  ccgacttca  cttcctcat  1260
gttctagga  aaggcagtt  tgggaaggt  atgctggcc  agcgcaggg  ctctgatga  1320
ctctacgcc  tcaagatct  gaaaaagga  gtgatcgtc  aggacgacg  tgtggactg  1380
acgctggtg  agaaacgtg  gctggcgct  gggggccgg  gtcctggcg  ccggcccca  1440
ttcctcacc  agctccact  caccttcca  accccggac  gcctgtatt  cgtgatgga  1500
tacgtcacc  ggggagact  gatgtacca  attcaacag  tgggcaagt  taaggagcc  1560
catgcagcg  tctacgcgg  agaaatcgc  atcggcctc  tcttccttc  caatcaggg  1620
atcatctac  gggacctga  gctggacaa  gtgatgctg  atgctgagg  acacatcaa  1680
atcactgac  ttggcatgt  taaggagaa  gtcttcccc  ggacgacaa  ccgcacctt  1740
tgcgggacc  cggactaca  agccccgga  atcattgcc  accagccct  tgggaagtc  1800
gtcgattgg  ggtcctttg  agttctgct  tatgagatg  tggcaggac  gcctccctt  1860
gatggggag  acgaggagg  gctgtttca  gccatcatg  aacaaactg  cacctaccc  1920
aagtcgctt  cccgggaag  cgtggccat  tgcaagggg  tcctgacca  gcacccagg  1980
aagcgcctg  gctcagggc  tgatgggga  cctaccatc  gtgcacatg  ctttttccg  2040
tggattgac  gggagcggc  ggaacgatt  gagatcccg  ctcctttca  accccgccc  2100
tgtggccgc  gcggcgaga  ctttgacaa  ttcttcacg  gggcggcgc  agcgctgac  2160
cctccagac  gcctagtcc  ggccagcat  gaccaggcc  atttccagg  cttcaccta  2220
gtgaacccc  acttcgtgc  cccggatgc  cgcagcccc  ccagcccag  gcctgtgcc  2280
gtcatgtaa  ctcacccgc  gccactagg  gtccccaac  tcccctccg  cgtgccggc  2340
gcagcccca  ttcaccccc  acttcacca  cccctgtcc  attctagat  ctgcacccc  2400
gcattccag  tctgccccc  cgggttcta  acgcccctc  caagcgttc  tggccttct  2460
aactccata  agcctctac  gccgtcccg  gttcaagac  tgagcg  2506



<210> 3699
<211> 697
<212> PRT
<213> Homo sapiens
<308> P05129
<400> 3699

Met Ala Gly Leu Gly Pro Gly Val Gly Asp Ser Glu Gly Gly Pro Arg 
  1               5                  10                  15
Pro Leu Phe Cys Arg Lys Gly Ala Leu Arg Gln Lys Val Val His Glu 
             20                  25                  30
Val Lys Ser His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr Phe 
         35                  40                  45
Cys Ser His Cys Thr Asp Phe Ile Trp Gly Ile Gly Lys Gln Gly Leu 
     50                  55                  60
Gln Cys Gln Val Cys Ser Phe Val Val His Arg Arg Cys His Glu Phe 
 65                  70                  75                  80
Val Thr Phe Glu Cys Pro Gly Ala Gly Lys Gly Pro Gln Thr Asp Asp 
                 85                  90                  95
Pro Arg Asn Lys His Lys Phe Arg Leu His Ser Tyr Ser Ser Pro Thr 
             100                105                110
Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Val His Gln Gly 
         115                120                125
Met Lys Cys Ser Cys Cys Glu Met Asn Val His Arg Arg Cys Val Arg 
     130                135                140
Ser Val Pro Ser Leu Cys Gly Val Asp His Thr Glu Arg Arg Gly Arg 
 145                150                155                160
Leu Gln Leu Glu Ile Arg Ala Pro Thr Ala Asp Glu Ile His Val Thr 
                 165                170                175
Val Gly Glu Ala Arg Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
             180                185                190
Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Arg Asn Leu Thr 
         195                200                205
Lys Gln Lys Thr Arg Thr Val Lys Ala Thr Leu Asn Pro Val Trp Asn 
     210                215                220
Glu Thr Phe Val Phe Asn Leu Lys Pro Gly Asp Val Glu Arg Arg Leu 
 225                230                235                240
Ser Val Glu Val Trp Asp Trp Asp Arg Thr Ser Arg Asn Asp Phe Met 
                 245                250                255
Gly Ala Met Ser Phe Gly Val Ser Glu Leu Leu Lys Ala Pro Val Asp 
             260                265                270
Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
         275                280                285
Pro Val Ala Asp Ala Asp Asn Cys Ser Leu Leu Gln Lys Phe Glu Ala 
     290                295                300
Cys Asn Tyr Pro Leu Glu Leu Tyr Glu Arg Val Arg Met Gly Pro Ser 
 305                310                315                320
Ser Ser Pro Ile Pro Ser Pro Ser Pro Ser Pro Thr Asp Pro Lys Arg 
                 325                330                335
Cys Phe Phe Gly Ala Ser Pro Gly Arg Leu His Ile Ser Asp Phe Ser 
             340                345                350
Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys Val Met Leu Ala 
         355                360                365
Glu Arg Arg Gly Ser Asp Glu Leu Tyr Ala Ile Lys Ile Leu Lys Lys 
     370                375                380
Asp Val Ile Val Gln Asp Asp Asp Val Asp Cys Thr Leu Val Glu Lys 
 385                390                395                400
Arg Val Leu Ala Leu Gly Gly Arg Gly Pro Gly Gly Arg Pro His Phe 
                 405                410                415
Leu Thr Gln Leu His Ser Thr Phe Gln Thr Pro Asp Arg Leu Tyr Phe 
             420                425                430
Val Met Glu Tyr Val Thr Gly Gly Asp Leu Met Tyr His Ile Gln Gln 
         435                440                445
Leu Gly Lys Phe Lys Glu Pro His Ala Ala Phe Tyr Ala Ala Glu Ile 
     450                455                460
Ala Ile Gly Leu Phe Phe Leu His Asn Gln Gly Ile Ile Tyr Arg Asp 
 465                470                475                480
Leu Lys Leu Asp Asn Val Met Leu Asp Ala Glu Gly His Ile Lys Ile 
                 485                490                495
Thr Asp Phe Gly Met Cys Lys Glu Asn Val Phe Pro Gly Thr Thr Thr 
             500                505                510
Arg Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala 
         515                520                525
Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ser Phe Gly Val Leu 
     530                535                540
Leu Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu 
 545                550                555                560
Glu Glu Leu Phe Gln Ala Ile Met Glu Gln Thr Val Thr Tyr Pro Lys 
                 565                570                575
Ser Leu Ser Arg Glu Ala Val Ala Ile Cys Lys Gly Phe Leu Thr Lys 
             580                585                590
His Pro Gly Lys Arg Leu Gly Ser Gly Pro Asp Gly Glu Pro Thr Ile 
         595                600                605
Arg Ala His Gly Phe Phe Arg Trp Ile Asp Trp Glu Arg Leu Glu Arg 
     610                615                620
Leu Glu Ile Pro Pro Pro Phe Arg Pro Arg Pro Cys Gly Arg Ser Gly 
 625                630                635                640
Glu Asn Phe Asp Lys Phe Phe Thr Arg Ala Ala Pro Ala Leu Thr Pro 
                 645                650                655
Pro Asp Arg Leu Val Leu Ala Ser Ile Asp Gln Ala Asp Phe Gln Gly 
             660                665                670
Phe Thr Tyr Val Asn Pro Asp Phe Val His Pro Asp Ala Arg Ser Pro 
         675                680                685
Thr Ser Pro Val Pro Val Pro Val Met 
     690                695



<210> 3700
<211> 1699
<212> DNA
<213> Rattus norvegicus
<308> M57276
<400> 3700

gaattcggc  cgaggtatt  tttctctct  cacttctcc  tttacacaa  tagacatag  60
cttctgggt  accagactg  gctcgccac  ttaaagata  taagcaaat  ctacctgaa  120
tactgaggg  cactgcctt  taaagggca  actatccca  catgggcat  agcagcctg  180
aattgctga  atatgttct  tttttcttt  actttcttt  ttgggtctg  ggctgttgc  240
ttttgggct  tgggatcca  cttctggtc  agaatacct  tggaatact  ttccgtaat  300
tccccttcc  gacacttgg  aatgttctg  tcattgtgg  ctccattat  atggtagtt  360
ccttcttgg  ctgcatggg  tcaatcaag  agaataagt  cctgcttat  tcgttcttt  420
ttctgctgc  gcttattct  cttgctgag  tgaccttag  catcctgct  tttgtgtat  480
aaaaaaaga  caacacgtt  gtggcagag  gcctgaatg  cagcatcca  cattatcac  540
ctgacaaca  caccaggat  gcatgggac  tcatccagt  acaactgca  tgttgtggt  600
taaatggct  aagtgattg  atcagtggt  caccatctt  ctgcccatc  ggtgcagat  660
ttcagggtt  ttataaaaa  gggcaggcg  ggtttcact  caatttctt  tatattgga  720
tcgttacca  ctgcgtatg  gtgatacag  tgctgggga  gtcctttgc  ctgacactg  780
actgccaga  tgacaaaac  agccaggct  tagggctgt  atttacacc  accttctgc  840
taagtgatt  atttctctc  agaaagtca  agcacccat  ccataagga  ttaaacaat  900
acgtgcctc  ctggcattt  gactttctc  tattccttc  ttgactgga  ctctgtctt  960
tacacatcc  gggaagaga  catttgtca  ggacttccc  catcaagca  aagacaaac  1020
ttaaccaac  gatagcagt  accatatcc  ttaaagatg  tgaaacata  ctgggtaat  1080
ttttaaaag  gacactgta  cactgtaat  tgatatcca  tgctagctg  aggtgtgat  1140
tatctcaga  tactggcct  ccacatgta  tccattgag  ttagcccca  atccaataa  1200
aagaggtcc  agtttaaat  ttagactct  aacaattgt  aaatcaatc  ctaccttct  1260
aatcttgct  ctgtcactc  acaaagtca  ataggagac  agctgaagg  aaatttgga  1320
tcccattca  tagataatt  acatgtcca  ttccctttt  aacacagtc  ttgggaata  1380
gaatcatac  gagatcttt  atcactgga  aaacattct  atttctttg  taaaatgta  1440
tattgattt  gttacatca  ccacacatc  atccatcca  ccatccatc  atccatcca  1500
ccatccata  aagactaat  attctcatc  taccatcag  cagtttgca  ctttgaatt  1560
cattgccaa  gaacaactc  gaagaatta  tatctccag  gtgttagct  ataatcata  1620
ccatgttga  gttgttgtt  tttctctat  aaataaggt  ctgttaatg  accatttta  1680
cctgtctcg  gccgaattc  1699



<210> 3701
<211> 218
<212> PRT
<213> Rattus norvegicus
<308> P24485
<400> 3701

Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe Asn 
  1               5                  10                  15
Phe Leu Phe Trp Val Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile His 
             20                  25                  30
Leu Leu Val Gln Asn Thr Tyr Gly Ile Leu Phe Arg Asn Leu Pro Phe 
         35                  40                  45
Leu Thr Leu Gly Asn Val Leu Val Ile Val Gly Ser Ile Ile Met Val 
     50                  55                  60
Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys Leu 
 65                  70                  75                  80
Leu Met Ser Phe Phe Val Leu Leu Leu Leu Ile Leu Leu Ala Glu Val 
                 85                  90                  95
Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Lys Lys Ile Asn Thr Leu 
             100                105                110
Val Ala Glu Gly Leu Asn Asp Ser Ile Gln His Tyr His Ser Asp Asn 
         115                120                125
Ser Thr Arg Met Ala Trp Asp Phe Ile Gln Ser Gln Leu Gln Cys Cys 
     130                135                140
Gly Val Asn Gly Ser Ser Asp Trp Ile Ser Gly Pro Pro Ser Ser Cys 
 145                150                155                160
Pro Ser Gly Ala Asp Val Gln Gly Cys Tyr Lys Lys Gly Gln Ala Trp 
                 165                170                175
Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Val Thr Ile Cys Val Cys 
             180                185                190
Val Ile Gln Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys Gln 
         195                200                205
Ile Asp Lys Thr Ser Gln Ala Leu Gly Leu 
     210                215



<210> 3702
<211> 1480
<212> DNA
<213> Homo sapiens
<308> M37033
<400> 3702

accagcctt  tctcggcca  ctcaaggat  atcactaaa  tctgccgaa  ggactgagg  60
acggtgcct  gaaaagggc  agaatatca  ggcatgggc  tgagtagct  gaaactgct  120
aagtatgtc  tgtttttct  caacttgct  ttttggatc  gtggctgct  cattttggg  180
tttgggatc  acctgctga  ccacaacaa  ttcggagtg  tcttccata  cctcccctc  240
ctcacgctg  gcaatgtgt  tgtcatcgt  ggctctatt  tcatggtag  tgccttcct  300
ggctgcatg  gctctatca  ggaaaacaa  tgtctgctt  tgtcgttct  catcctgct  360
ctgattatc  tccttgctg  ggtgacctt  gccatcctg  tctttgtat  tgaacagaa  420
ctgaatgag  atgtggcta  gggtctgac  gacagcatc  accgttacc  ctcagacaa  480
agcaccaag  cagcgtggg  ctccatcca  tcatttctg  agtgttgtg  tataaatgg  540
acgagtgat  ggaccagtg  cccaccagc  tcttgcccc  cagatcgaa  agtggaggg  600
tgctatgcg  aagcaagac  gtggtttca  tccaatttc  tgtatatcg  aatcatcac  660
atctgtgta  gtgtgattg  ggtgttggg  atgtccttt  cactgaccc  gaactgcca  720
attgacaaa  ccagccaga  catagggct  tgatctgca  tagttctgt  gtgaagaga  780
ttgtttcat  tccggaaat  caaaaccat  tatagcatg  agccctaca  gatcactgc  840
ggatgatcc  cctcccatc  tttcccttt  taggtccct  tcttataca  ccagagaag  900
gggtgttgg  caggcacat  ccatctcag  cagcaagac  atctttcac  cactgacgg  960
agcagccat  tctctcaaa  tggtgaaac  aatatctga  catctttta  acaagagag  1020
caaagacaa  ctggattta  tggcccaac  tcaaagggt  aacccagga  atgaatttt  1080
gcatcttcc  attgtcgaa  tagtctcca  cctctaaat  atgcccagt  ttctcccca  1140
agtcaagca  gagactagt  gaagggagt  ctggggcca  gctcactgg  ccattgtca  1200
aaccctctg  ttctctttg  ctaagtgcc  tggctacag  aattacaca  ttctctttc  1260
ccaaagggc  agatctcat  tcaatttct  tattagagg  ccttattga  gtgttctaa  1320
tctttccag  aaaaaacta  ccagtgatt  atatcctga  ttcaaccag  cacttagct  1380
ataatcaca  taagaagac  tctggtatt  tctctctat  agataagat  ttgttaatg  1440
actatttta  tcttcaata  ataaaacag  ttattatctc  1480



<210> 3703
<211> 219
<212> PRT
<213> Homo sapiens
<308> P19397
<400> 3703

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
  1               5                  10                  15
Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
             20                  25                  30
Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
         35                  40                  45
Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
     50                  55                  60
Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
 65                  70                  75                  80
Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                 85                  90                  95
Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
             100                105                110
Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
         115                120                125
Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
     130                135                140
Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
 145                150                155                160
Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                 165                170                175
Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
             180                185                190
Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
         195                200                205
Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
     210                215



<210> 3705
<211> 502
<212> PRT
<213> Rattus norvegicus
<308> P21425
<400> 3705

Met Ala Gly Val Phe Asp Ile Asp Leu Asp Gln Pro Glu Asp Ala Gly 
  1               5                  10                  15
Ser Glu Asp Glu Leu Glu Glu Gly Gly Gln Leu Asn Glu Ser Met Asp 
             20                  25                  30
His Gly Gly Val Gly Pro Tyr Glu Leu Gly Met Glu His Cys Glu Lys 
         35                  40                  45
Phe Glu Ile Ser Glu Thr Ser Val Asn Arg Gly Pro Glu Lys Ile Arg 
     50                  55                  60
Pro Glu Cys Phe Glu Leu Leu Arg Val Leu Gly Lys Gly Gly Tyr Gly 
 65                  70                  75                  80
Lys Val Phe Gln Val Arg Lys Val Thr Gly Ala Asn Thr Gly Lys Ile 
                 85                  90                  95
Phe Ala Met Lys Val Leu Lys Lys Ala Met Ile Val Arg Asn Ala Lys 
             100                105                110
Asp Thr Ala His Thr Lys Ala Glu Arg Asn Ile Leu Glu Glu Val Lys 
         115                120                125
His Pro Phe Ile Val Asp Leu Ile Tyr Ala Phe Gln Thr Gly Gly Lys 
     130                135                140
Leu Tyr Leu Ile Leu Glu Tyr Leu Ser Gly Gly Glu Leu Phe Met Gln 
 145                150                155                160
Leu Glu Arg Glu Gly Ile Phe Met Glu Asp Thr Ala Cys Phe Tyr Leu 
                 165                170                175
Ala Glu Ile Ser Met Ala Leu Gly His Leu His Gln Lys Gly Ile Ile 
             180                185                190
Tyr Arg Asp Leu Lys Pro Glu Asn Ile Met Leu Asn His Gln Gly His 
         195                200                205
Val Lys Leu Thr Asp Phe Gly Leu Cys Lys Glu Ser Ile His Asp Gly 
     210                215                220
Thr Val Thr His Thr Phe Cys Gly Thr Ile Glu Tyr Met Ala Pro Glu 
 225                230                235                240
Ile Leu Met Arg Ser Gly His Asn Arg Ala Val Asp Trp Trp Ser Leu 
                 245                250                255
Gly Ala Leu Met Tyr Asp Met Leu Thr Gly Ala Pro Pro Phe Thr Gly 
             260                265                270
Glu Asn Arg Lys Lys Thr Ile Asp Lys Ile Leu Lys Cys Lys Leu Asn 
         275                280                285
Leu Pro Pro Tyr Leu Thr Gln Glu Ala Arg Asp Leu Leu Lys Lys Leu 
     290                295                300
Leu Lys Arg Asn Ala Ala Ser Arg Leu Gly Ala Gly Pro Gly Asp Ala 
 305                310                315                320
Gly Glu Val Gln Ala His Pro Phe Phe Arg His Ile Asn Trp Glu Glu 
                 325                330                335
Leu Leu Ala Arg Lys Val Glu Pro Pro Phe Lys Pro Leu Leu Gln Ser 
             340                345                350
Glu Glu Asp Val Ser Gln Phe Asp Ser Lys Phe Thr Arg Gln Thr Pro 
         355                360                365
Val Asp Ser Pro Asp Asp Ser Thr Leu Ser Glu Ser Ala Asn Gln Val 
     370                375                380
Phe Leu Gly Phe Thr Tyr Val Ala Pro Ser Val Leu Glu Ser Val Lys 
 385                390                395                400
Glu Lys Phe Ser Phe Glu Pro Lys Ile Arg Ser Pro Arg Arg Phe Ile 
                 405                410                415
Gly Ser Pro Arg Thr Pro Val Ser Pro Val Lys Phe Ser Pro Gly Asp 
             420                425                430
Phe Trp Gly Arg Gly Ala Ser Ala Ser Thr Ala Asn Pro Gln Thr Pro 
         435                440                445
Val Glu Tyr Pro Met Glu Thr Ser Gly Ile Glu Gln Met Asp Val Thr 
     450                455                460
Thr Ser Gly Glu Ala Ser Ala Pro Leu Pro Ile Arg Gln Pro Asn Ser 
 465                470                475                480
Gly Pro Tyr Lys Lys Gln Ala Phe Pro Met Ile Ser Lys Arg Pro Glu 
                 485                490                495
His Leu Arg Met Asn Leu 
             500



<210> 3706
<211> 2346
<212> DNA
<213> Homo sapiens
<308> M60724
<400> 3706

gcacgaggc  gcggcgggt  cgggcccat  aggcgacga  ggaggcggg  cggctttta  1860
ccagccccg  acttccgag  cagggaagc  gaggacatg  caggagtgt  tgacataga  1920
ctggaccag  cagaggacg  gggctctga  gatgagctg  aggaggggg  tcagttaaa  1980
gaaagcatg  accatgggg  agttggacc  tatgaactt  gcatggaac  ttgtgagaa  2040
tttgaaatc  cagaaacta  tgtgaacag  gggccagaa  aaatcagac  agaatgttt  2100
gagctactt  gggtacttg  taaaggggg  tatggaaag  tttttcaag  acgaaaagt  2160
acaggagca  atactggga  aatatttgc  atgaaggtg  ttaaaaagg  aatgatagt  2220
agaaatgct  aagatacag  tcatacaaa  gcagaacgg  atattctgg  ggaagtaaa  2280
catcccttc  tcgtggatt  aatttatgc  tttcagact  gtggaaaac  ctacctcat  2340
cttgag  2346



<210> 3707
<211> 502
<212> PRT
<213> Homo sapiens
<308> P23443
<400> 3707

Met Ala Gly Val Phe Asp Ile Asp Leu Asp Gln Pro Glu Asp Ala Gly 
  1               5                  10                  15
Ser Glu Asp Glu Leu Glu Glu Gly Gly Gln Leu Asn Glu Ser Met Asp 
             20                  25                  30
His Gly Gly Val Gly Pro Tyr Glu Leu Gly Met Glu His Cys Glu Lys 
         35                  40                  45
Phe Glu Ile Ser Glu Thr Ser Val Asn Arg Gly Pro Glu Lys Ile Arg 
     50                  55                  60
Pro Glu Cys Phe Glu Leu Leu Arg Val Leu Gly Lys Gly Gly Tyr Gly 
 65                  70                  75                  80
Lys Val Phe Gln Val Arg Lys Val Thr Gly Ala Asn Thr Gly Lys Ile 
                 85                  90                  95
Phe Ala Met Lys Val Leu Lys Lys Ala Met Ile Val Arg Asn Ala Lys 
             100                105                110
Asp Thr Ala His Thr Lys Ala Glu Arg Asn Ile Leu Glu Glu Val Lys 
         115                120                125
His Pro Phe Ile Val Asp Leu Ile Tyr Ala Phe Gln Thr Gly Gly Lys 
     130                135                140
Leu Tyr Leu Ile Leu Glu Tyr Leu Ser Gly Gly Glu Leu Phe Met Gln 
 145                150                155                160
Leu Glu Arg Glu Gly Ile Phe Met Glu Asp Thr Ala Cys Phe Tyr Leu 
                 165                170                175
Ala Glu Ile Ser Met Ala Leu Gly His Leu His Gln Lys Gly Ile Ile 
             180                185                190
Tyr Arg Asp Leu Lys Pro Glu Asn Ile Met Leu Asn His Gln Gly His 
         195                200                205
Val Lys Leu Thr Asp Phe Gly Leu Cys Lys Glu Ser Ile His Asp Gly 
     210                215                220
Thr Val Thr His Thr Phe Cys Gly Thr Ile Glu Tyr Met Ala Pro Glu 
 225                230                235                240
Ile Leu Met Arg Ser Gly His Asn Arg Ala Val Asp Trp Trp Ser Leu 
                 245                250                255
Gly Ala Leu Met Tyr Asp Met Leu Thr Gly Ala Pro Pro Phe Thr Gly 
             260                265                270
Glu Asn Arg Lys Lys Thr Ile Asp Lys Ile Leu Lys Cys Lys Leu Asn 
         275                280                285
Leu Pro Pro Tyr Leu Thr Gln Glu Ala Arg Asp Leu Leu Lys Lys Leu 
     290                295                300
Leu Lys Arg Asn Ala Ala Ser Arg Leu Gly Ala Gly Pro Gly Asp Ala 
 305                310                315                320
Gly Glu Val Gln Ala His Pro Phe Phe Arg His Ile Asn Trp Glu Glu 
                 325                330                335
Leu Leu Ala Arg Lys Val Glu Pro Pro Phe Lys Pro Leu Leu Gln Ser 
             340                345                350
Glu Glu Asp Val Ser Gln Phe Asp Ser Lys Phe Thr Arg Gln Thr Pro 
         355                360                365
Val Asp Ser Pro Asp Asp Ser Thr Leu Ser Glu Ser Ala Asn Gln Val 
     370                375                380
Phe Leu Gly Phe Thr Tyr Val Ala Pro Ser Val Leu Glu Ser Val Lys 
 385                390                395                400
Glu Lys Phe Ser Phe Glu Pro Lys Ile Arg Ser Pro Arg Arg Phe Ile 
                 405                410                415
Gly Ser Pro Arg Thr Pro Val Ser Pro Val Lys Phe Ser Pro Gly Asp 
             420                425                430
Phe Trp Gly Arg Gly Ala Ser Ala Ser Thr Ala Asn Pro Gln Thr Pro 
         435                440                445
Val Glu Tyr Pro Met Glu Thr Ser Gly Ile Glu Gln Met Asp Val Thr 
     450                455                460
Met Ser Gly Glu Ala Ser Ala Pro Leu Pro Ile Arg Gln Pro Asn Ser 
 465                470                475                480
Gly Pro Tyr Lys Lys Gln Ala Phe Pro Met Ile Ser Lys Arg Pro Glu 
                 485                490                495
His Leu Arg Met Asn Leu 
             500



<210> 3708
<211> 1712
<212> DNA
<213> Rattus norvegicus
<308> M57728
<400> 3708

atggcgacg  cagtgtggg  ggctgcgcg  ctacttcgg  gttctgcgg  gctgtgcgc  60
cggcccaag  tcggttctc  tgcacacag  cggttcagc  gtggcgcca  ctaccccaa  120
atccctctc  cttctccct  gcccggagt  cccaagcct  tttttgcta  agttgatgg  180
caggaaaag  ttgaaacca  agtcaccac  ctggacaat  ggcttcgtg  ggcatctca  240
aataagttt  gacagttct  taccttagg  attcttatt  attcaggat  acgatatga  300
gcgaaatat  ttagtggaa  tgctcattt  ctggaaaaa  tggcatttt  gtctaccgc  360
cgatttgac  gcaaagatg  aattctgct  accctggaa  aacatggtg  tatctgtga  420
tgccagacc  cgagagaca  caccatgta  gctgtgtct  ctgacagca  aggcttgga  480
actgtggtg  gcctgctgg  tgatgtggt  ctgcacccc  gcctgacag  tgaggaaat  540
gagatgacg  ggatggctg  tcagtttga  cttgaggac  tgaacatga  acctgaccc  600
gagccactg  tcaccgaga  gattcatga  gctgctttt  gggagaaca  ggtgggcct  660
caccggttt  gtcctgtgg  gaatatcgg  aagattgac  gagaagtgc  gcattccta  720
ctgaagaac  actacaccc  cgaccgcat  gtgcttgct  gagtgggcg  ggagcatga  780
cacctggtc  aatgtgcca  aaagtacct  ctgggagtg  agcctgcct  gggagctcc  840
ggagctgtg  ggatgttga  agctcagtg  cacagtaca  gggggggat  atcaaggtg  900
agagagaca  gtcaaatgt  agccttgcg  ccaccccga  tccagagct  acacatata  960
ggtggggct  gagagctgc  ccttctgga  gaggatttc  tcccctttg  tgtgttgaa  1020
atgatgatg  gaggcgggg  ctccttctc  gccggaggg  ctggcaaag  catgttctc  1080
aggctctac  tcaacgtgc  caatcggca  cactggatg  ataatgcaa  ctcctacca  1140
cacagctat  aagacacag  cctcctgtg  atccatgcc  gcgcagacc  tcgacaggt  1200
cgagaaatg  tagaaatca  cacaaagga  tttattttg  tgggccgaa  ggtggattt  1260
gtggagctg  agcgggcca  gacacagct  atgtccatg  tcatgatga  cttggagtc  1320
aggcctgtg  tctttgagg  tgtggggag  caggtgttg  ctacacatt  aagaaagct  1380
ccccatgag  tgtgcacac  cattcgcaa  gtgaagccg  aagatatca  gagggttgc  1440
tccaagatg  tccgaggca  gcctgctgt  gcggctctg  gtgatttga  tgacctgcc  1500
acgtatgaa  acatccagg  agcgctgtc  agcagagat  ggcgcctgc  cagaacata  1560
cggctgttc  ggtagagcc  tccagcgga  gctgcagag  gcttctgtg  atgttactg  1620
tggtgtgga  actgcataa  aatagctag  tctgtgaac  gtgccaaca  ggaagctct  1680
gaaacttga  tgaaagtta  tgttgccac  gc  1712



<210> 3709
<211> 524
<212> PRT
<213> Rattus norvegicus
<308> P20069
<400> 3709

Met Ala Thr Ala Val Trp Ala Ala Ala Arg Leu Leu Arg Gly Ser Ala 
  1               5                  10                  15
Ala Leu Cys Ala Arg Pro Lys Phe Gly Ser Pro Ala His Arg Arg Phe 
             20                  25                  30
Ser Ser Gly Ala Thr Tyr Pro Asn Ile Pro Leu Ser Ser Pro Leu Pro 
         35                  40                  45
Gly Val Pro Lys Pro Ile Phe Ala Thr Val Asp Gly Gln Glu Lys Phe 
     50                  55                  60
Glu Thr Lys Val Thr Thr Leu Asp Asn Gly Leu Arg Val Ala Ser Gln 
 65                  70                  75                  80
Asn Lys Phe Gly Gln Phe Cys Thr Leu Gly Ile Leu Ile Asn Ser Gly 
                 85                  90                  95
Ser Arg Tyr Glu Ala Lys Tyr Leu Ser Gly Ile Ala His Phe Leu Glu 
             100                105                110
Lys Leu Ala Phe Ser Ser Thr Ala Arg Phe Asp Ser Lys Asp Glu Ile 
         115                120                125
Leu Leu Thr Leu Glu Lys His Gly Gly Ile Cys Asp Cys Gln Thr Ser 
     130                135                140
Arg Asp Thr Thr Met Tyr Ala Val Ser Ala Asp Ser Lys Gly Leu Asp 
 145                150                155                160
Thr Val Val Gly Leu Leu Ala Asp Val Val Leu His Pro Arg Leu Thr 
                 165                170                175
Asp Glu Glu Ile Glu Met Thr Arg Met Ala Val Gln Phe Glu Leu Glu 
             180                185                190
Asp Leu Asn Met Arg Pro Asp Pro Glu Pro Leu Leu Thr Glu Met Ile 
         195                200                205
His Glu Ala Ala Phe Arg Glu Asn Thr Val Gly Leu His Arg Phe Cys 
     210                215                220
Pro Val Glu Asn Ile Gly Lys Ile Asp Arg Glu Val Leu His Ser Tyr 
 225                230                235                240
Leu Lys Asn Tyr Tyr Thr Pro Asp Arg Met Val Leu Ala Gly Val Gly 
                 245                250                255
Val Glu His Glu His Leu Val Glu Cys Ala Arg Lys Tyr Leu Leu Gly 
             260                265                270
Val Gln Pro Ala Trp Gly Ala Pro Gly Ala Val Trp Met Leu Thr Ala 
         275                280                285
Gln Trp His Ser Thr Arg Gly Gly Ser Ser Arg Trp Arg Glu Thr Cys 
     290                295                300
Gln Met Ser Ala Leu Arg Pro Pro Arg Phe Gln Ser Ser His Ile Tyr 
 305                310                315                320
Gly Gly Ala Arg Glu Leu Leu Leu Leu Glu Glu Asp Phe Ile Pro Phe 
                 325                330                335
Ala Val Leu Asn Met Met Met Gly Gly Gly Gly Ser Phe Ser Ala Gly 
             340                345                350
Gly Pro Gly Lys Gly Met Phe Ser Arg Leu Tyr Leu Asn Val Leu Asn 
         355                360                365
Arg His His Trp Met Tyr Asn Ala Thr Ser Tyr His His Ser Tyr Glu 
     370                375                380
Asp Thr Gly Leu Leu Cys Ile His Ala Ser Ala Asp Pro Arg Gln Val 
 385                390                395                400
Arg Glu Met Val Glu Ile Ile Thr Lys Glu Phe Ile Leu Met Gly Arg 
                 405                410                415
Thr Val Asp Leu Val Glu Leu Glu Arg Ala Lys Thr Gln Leu Met Ser 
             420                425                430
Met Leu Met Met Asn Leu Glu Ser Arg Pro Val Ile Phe Glu Asp Val 
         435                440                445
Gly Arg Gln Val Leu Ala Thr His Ser Arg Lys Leu Pro His Glu Leu 
     450                455                460
Cys Thr Leu Ile Arg Asn Val Lys Pro Glu Asp Ile Lys Arg Val Ala 
 465                470                475                480
Ser Lys Met Leu Arg Gly Lys Pro Ala Val Ala Ala Leu Gly Asp Leu 
                 485                490                495
Thr Asp Leu Pro Thr Tyr Glu His Ile Gln Ala Ala Leu Ser Ser Arg 
             500                505                510
Asp Gly Arg Leu Pro Arg Thr Tyr Arg Leu Phe Arg 
         515                520



<210> 3710
<211> 2083
<212> DNA
<213> Homo sapiens
<308> D21064
<400> 3710

agacgcaag  tggcggctg  ggtgctggc  gcgacgcgg  tgctgcggg  ctcgggttc  60
tggggctgt  cgcggctga  gtttggacc  cctgcgtac  gacggttta  tagtggtgg  120
gcctatccc  acatccccc  ctcttctcc  ttacctgga  tacccaagc  tgtttttgc  180
acagttgat  gacaggaaa  gtttgaaac  aaagtaacc  cattggata  tgggcttcg  240
gtggcatct  agaataagt  tggacagtt  tgtacagta  gaattctta  caattcagg  300
tcgagatat  aagcgaaat  ccttagtgg  attgctcac  ttttggaaa  attggcatt  360
tcgtctact  ctcgatttg  cagcaaaga  gaaattctg  ttacgttgg  aaagcatgg  420
ggtatctgt  actgccaga  atcaagaga  accaccatg  atgctgtgt  tgctgatag  480
aaaggcttg  acacggtgg  tgccttact  gctgatgtg  ttctgcagc  ccggctaac  540
gatgaagaa  tcgagatga  gcggatggc  gtccagttt  agctggagg  cctgaacct  600
cggcctgac  cagagccac  tctcaccga  atgattcat  aagcggctt  cagggagaa  660
acagttggc  tccaccgtt  ctgccccac  gaaaacgta  caaagatca  ccgagaggt  720
ctgcattcc  acctgagga  ctactacac  cccgaccgc  tggtgctgg  cggcgtggg  780
gtggagcac  agcatctgg  ggactgtgc  cggaagtac  tcctggggg  ccagccggc  840
tgggggagc  cagaggccg  ggatattga  agatctgtg  cccagtaca  tggggggat  900
gccaagcta  aaagagaca  gtccaatgt  agcctgggc  cgaccccca  ccccgagct  960
acgcacatc  tggttggac  ggagagctg  tccttcctg  aggaggact  catcccctt  1020
gcagtgttg  acatgatga  gggcggagg  ggctccttc  cggctggtg  gcccggcaa  1080
ggcatgttc  ccaggctct  cctcaacgt  ctcaacagg  accactgga  gtataacgc  1140
acctcctac  accacagct  cgaggacac  ggcctcctt  gcatccatg  cagcgccga  1200
ccaagacag  ttcgagaaa  ggtagaaat  atcacaaag  agtttattt  aatgggcgg  1260
accgtggac  cggtggagc  ggaacgagc  aagacgcag  tgacatcaa  gctcatgat  1320
aacctggaa  ccaggcctg  gatcttcga  gatgtgggg  ggcaggtgc  ggccactcg  1380
tccagaaag  tgccgcacg  gctgtgcac  ctcatccgc  acgtgaagc  ggaagatgt  1440
aagagagtc  cttctaaga  gctccgagg  aagccggca  tggccgccc  gggtgacct  1500
actgacctg  ccacgtatg  ggacatcca  accgccctg  cgagtaagg  cgggcgcct  1560
cccaggacg  accggctct  ccggtagaa  cgctccccg  cctgacaga  ccagggagc  1620
gcagctgga  cccgttccc  tgcgtgtta  tttggacac  aatttagtc  aaaaagctg  1680
ctggttgta  aaacggtgc  aacaatgtc  ccacagcac  cacgcggtt  gcattcttt  1740
ggaactcaa  gtgccgatc  gtggagtca  tatcgagcc  gaccaccgc  agccaggaa  1800
caggtgaag  gcccagcgc  ggagtgcag  gtgccacga  gagggcggt  ggtgcttcc  1860
tcctcgggc  gtgggcaca  ggggccccg  aggttcctt  gaggagccc  gagctggga  1920
gcagcaaag  ctgacctat  aaagcctcc  ggaggccac  gtgctgggt  ccaggactc  1980
cctctgaca  gcaggagaa  gtaagggcc  ggtcagctc  aaggagcgc  ctccacgcg  2040
gtgcacaca  cttccctgg  aataaagag  tggcatctt  ctt  2083



<210> 3711
<211> 525
<212> PRT
<213> Homo sapiens
<308> Q10713
<400> 3711

Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg Gly Ser Gly 
  1               5                  10                  15
Ser Trp Gly Cys Ser Arg Leu Arg Phe Gly Pro Pro Ala Tyr Arg Arg 
             20                  25                  30
Phe Ser Ser Gly Gly Ala Tyr Pro Asn Ile Pro Leu Ser Ser Pro Leu 
         35                  40                  45
Pro Gly Val Pro Lys Pro Val Phe Ala Thr Val Asp Gly Gln Glu Lys 
     50                  55                  60
Phe Glu Thr Lys Val Thr Thr Leu Asp Asn Gly Leu Arg Val Ala Ser 
 65                  70                  75                  80
Gln Asn Lys Phe Gly Gln Phe Cys Thr Val Gly Ile Leu Ile Asn Ser 
                 85                  90                  95
Gly Ser Arg Tyr Glu Ala Lys Tyr Leu Ser Gly Ile Ala His Phe Leu 
             100                105                110
Glu Lys Leu Ala Phe Ser Ser Thr Ala Arg Phe Asp Ser Lys Asp Glu 
         115                120                125
Ile Leu Leu Thr Leu Glu Lys His Gly Gly Ile Cys Asp Cys Gln Thr 
     130                135                140
Ser Arg Asp Thr Thr Met Tyr Ala Val Ser Ala Asp Ser Lys Gly Leu 
 145                150                155                160
Asp Thr Val Val Ala Leu Leu Ala Asp Val Val Leu Gln Pro Arg Leu 
                 165                170                175
Thr Asp Glu Glu Val Glu Met Thr Arg Met Ala Val Gln Phe Glu Leu 
             180                185                190
Glu Asp Leu Asn Leu Arg Pro Asp Pro Glu Pro Leu Leu Thr Glu Met 
         195                200                205
Ile His Glu Ala Ala Tyr Arg Glu Asn Thr Val Gly Leu His Arg Phe 
     210                215                220
Cys Pro Thr Glu Asn Val Ala Lys Ile Asn Arg Glu Val Leu His Ser 
 225                230                235                240
Tyr Leu Arg Asn Tyr Tyr Thr Pro Asp Arg Met Val Leu Ala Gly Val 
                 245                250                255
Gly Val Glu His Glu His Leu Val Asp Cys Ala Arg Lys Tyr Leu Leu 
             260                265                270
Gly Val Gln Pro Ala Trp Gly Ser Ala Glu Ala Val Asp Ile Asp Arg 
         275                280                285
Ser Val Ala Gln Tyr Thr Gly Gly Ile Ala Lys Leu Glu Arg Asp Met 
     290                295                300
Ser Asn Val Ser Leu Gly Pro Thr Pro Ile Pro Glu Leu Thr His Ile 
 305                310                315                320
Met Val Gly Leu Glu Ser Cys Ser Phe Leu Glu Glu Asp Phe Ile Pro 
                 325                330                335
Phe Ala Val Leu Asn Met Met Met Gly Gly Gly Gly Ser Phe Ser Ala 
             340                345                350
Gly Gly Pro Gly Lys Gly Met Phe Ser Arg Leu Tyr Leu Asn Val Leu 
         355                360                365
Asn Arg His His Trp Met Tyr Asn Ala Thr Ser Tyr His His Ser Tyr 
     370                375                380
Glu Asp Thr Gly Leu Leu Cys Ile His Ala Ser Ala Asp Pro Arg Gln 
 385                390                395                400
Val Arg Glu Met Val Glu Ile Ile Thr Lys Glu Phe Ile Leu Met Gly 
                 405                410                415
Gly Thr Val Asp Thr Val Glu Leu Glu Arg Ala Lys Thr Gln Leu Thr 
             420                425                430
Ser Met Leu Met Met Asn Leu Glu Ser Arg Pro Val Ile Phe Glu Asp 
         435                440                445
Val Gly Arg Gln Val Leu Ala Thr Arg Ser Arg Lys Leu Pro His Glu 
     450                455                460
Leu Cys Thr Leu Ile Arg Asn Val Lys Pro Glu Asp Val Lys Arg Val 
 465                470                475                480
Ala Ser Lys Met Leu Arg Gly Lys Pro Ala Val Ala Ala Leu Gly Asp 
                 485                490                495
Leu Thr Asp Leu Pro Thr Tyr Glu Asp Ile Gln Thr Ala Leu Ser Ser 
             500                505                510
Lys Asp Gly Arg Leu Pro Arg Thr Tyr Arg Leu Phe Arg 
         515                520                525



<210> 3712
<211> 1712
<212> DNA
<213> Rattus norvegicus
<308> M57728
<400> 3712

atggcgacg  cagtgtggg  ggctgcgcg  ctacttcgg  gttctgcgg  gctgtgcgc  60
cggcccaag  tcggttctc  tgcacacag  cggttcagc  gtggcgcca  ctaccccaa  120
atccctctc  cttctccct  gcccggagt  cccaagcct  tttttgcta  agttgatgg  180
caggaaaag  ttgaaacca  agtcaccac  ctggacaat  ggcttcgtg  ggcatctca  240
aataagttt  gacagttct  taccttagg  attcttatt  attcaggat  acgatatga  300
gcgaaatat  ttagtggaa  tgctcattt  ctggaaaaa  tggcatttt  gtctaccgc  360
cgatttgac  gcaaagatg  aattctgct  accctggaa  aacatggtg  tatctgtga  420
tgccagacc  cgagagaca  caccatgta  gctgtgtct  ctgacagca  aggcttgga  480
actgtggtg  gcctgctgg  tgatgtggt  ctgcacccc  gcctgacag  tgaggaaat  540
gagatgacg  ggatggctg  tcagtttga  cttgaggac  tgaacatga  acctgaccc  600
gagccactg  tcaccgaga  gattcatga  gctgctttt  gggagaaca  ggtgggcct  660
caccggttt  gtcctgtgg  gaatatcgg  aagattgac  gagaagtgc  gcattccta  720
ctgaagaac  actacaccc  cgaccgcat  gtgcttgct  gagtgggcg  ggagcatga  780
cacctggtc  aatgtgcca  aaagtacct  ctgggagtg  agcctgcct  gggagctcc  840
ggagctgtg  ggatgttga  agctcagtg  cacagtaca  gggggggat  atcaaggtg  900
agagagaca  gtcaaatgt  agccttgcg  ccaccccga  tccagagct  acacatata  960
ggtggggct  gagagctgc  ccttctgga  gaggatttc  tcccctttg  tgtgttgaa  1020
atgatgatg  gaggcgggg  ctccttctc  gccggaggg  ctggcaaag  catgttctc  1080
aggctctac  tcaacgtgc  caatcggca  cactggatg  ataatgcaa  ctcctacca  1140
cacagctat  aagacacag  cctcctgtg  atccatgcc  gcgcagacc  tcgacaggt  1200
cgagaaatg  tagaaatca  cacaaagga  tttattttg  tgggccgaa  ggtggattt  1260
gtggagctg  agcgggcca  gacacagct  atgtccatg  tcatgatga  cttggagtc  1320
aggcctgtg  tctttgagg  tgtggggag  caggtgttg  ctacacatt  aagaaagct  1380
ccccatgag  tgtgcacac  cattcgcaa  gtgaagccg  aagatatca  gagggttgc  1440
tccaagatg  tccgaggca  gcctgctgt  gcggctctg  gtgatttga  tgacctgcc  1500
acgtatgaa  acatccagg  agcgctgtc  agcagagat  ggcgcctgc  cagaacata  1560
cggctgttc  ggtagagcc  tccagcgga  gctgcagag  gcttctgtg  atgttactg  1620
tggtgtgga  actgcataa  aatagctag  tctgtgaac  gtgccaaca  ggaagctct  1680
gaaacttga  tgaaagtta  tgttgccac  gc  1712



<210> 3713
<211> 524
<212> PRT
<213> Rattus norvegicus
<308> P20069
<400> 3713

Met Ala Thr Ala Val Trp Ala Ala Ala Arg Leu Leu Arg Gly Ser Ala 
  1               5                  10                  15
Ala Leu Cys Ala Arg Pro Lys Phe Gly Ser Pro Ala His Arg Arg Phe 
             20                  25                  30
Ser Ser Gly Ala Thr Tyr Pro Asn Ile Pro Leu Ser Ser Pro Leu Pro 
         35                  40                  45
Gly Val Pro Lys Pro Ile Phe Ala Thr Val Asp Gly Gln Glu Lys Phe 
     50                  55                  60
Glu Thr Lys Val Thr Thr Leu Asp Asn Gly Leu Arg Val Ala Ser Gln 
 65                  70                  75                  80
Asn Lys Phe Gly Gln Phe Cys Thr Leu Gly Ile Leu Ile Asn Ser Gly 
                 85                  90                  95
Ser Arg Tyr Glu Ala Lys Tyr Leu Ser Gly Ile Ala His Phe Leu Glu 
             100                105                110
Lys Leu Ala Phe Ser Ser Thr Ala Arg Phe Asp Ser Lys Asp Glu Ile 
         115                120                125
Leu Leu Thr Leu Glu Lys His Gly Gly Ile Cys Asp Cys Gln Thr Ser 
     130                135                140
Arg Asp Thr Thr Met Tyr Ala Val Ser Ala Asp Ser Lys Gly Leu Asp 
 145                150                155                160
Thr Val Val Gly Leu Leu Ala Asp Val Val Leu His Pro Arg Leu Thr 
                 165                170                175
Asp Glu Glu Ile Glu Met Thr Arg Met Ala Val Gln Phe Glu Leu Glu 
             180                185                190
Asp Leu Asn Met Arg Pro Asp Pro Glu Pro Leu Leu Thr Glu Met Ile 
         195                200                205
His Glu Ala Ala Phe Arg Glu Asn Thr Val Gly Leu His Arg Phe Cys 
     210                215                220
Pro Val Glu Asn Ile Gly Lys Ile Asp Arg Glu Val Leu His Ser Tyr 
 225                230                235                240
Leu Lys Asn Tyr Tyr Thr Pro Asp Arg Met Val Leu Ala Gly Val Gly 
                 245                250                255
Val Glu His Glu His Leu Val Glu Cys Ala Arg Lys Tyr Leu Leu Gly 
             260                265                270
Val Gln Pro Ala Trp Gly Ala Pro Gly Ala Val Trp Met Leu Thr Ala 
         275                280                285
Gln Trp His Ser Thr Arg Gly Gly Ser Ser Arg Trp Arg Glu Thr Cys 
     290                295                300
Gln Met Ser Ala Leu Arg Pro Pro Arg Phe Gln Ser Ser His Ile Tyr 
 305                310                315                320
Gly Gly Ala Arg Glu Leu Leu Leu Leu Glu Glu Asp Phe Ile Pro Phe 
                 325                330                335
Ala Val Leu Asn Met Met Met Gly Gly Gly Gly Ser Phe Ser Ala Gly 
             340                345                350
Gly Pro Gly Lys Gly Met Phe Ser Arg Leu Tyr Leu Asn Val Leu Asn 
         355                360                365
Arg His His Trp Met Tyr Asn Ala Thr Ser Tyr His His Ser Tyr Glu 
     370                375                380
Asp Thr Gly Leu Leu Cys Ile His Ala Ser Ala Asp Pro Arg Gln Val 
 385                390                395                400
Arg Glu Met Val Glu Ile Ile Thr Lys Glu Phe Ile Leu Met Gly Arg 
                 405                410                415
Thr Val Asp Leu Val Glu Leu Glu Arg Ala Lys Thr Gln Leu Met Ser 
             420                425                430
Met Leu Met Met Asn Leu Glu Ser Arg Pro Val Ile Phe Glu Asp Val 
         435                440                445
Gly Arg Gln Val Leu Ala Thr His Ser Arg Lys Leu Pro His Glu Leu 
     450                455                460
Cys Thr Leu Ile Arg Asn Val Lys Pro Glu Asp Ile Lys Arg Val Ala 
 465                470                475                480
Ser Lys Met Leu Arg Gly Lys Pro Ala Val Ala Ala Leu Gly Asp Leu 
                 485                490                495
Thr Asp Leu Pro Thr Tyr Glu His Ile Gln Ala Ala Leu Ser Ser Arg 
             500                505                510
Asp Gly Arg Leu Pro Arg Thr Tyr Arg Leu Phe Arg 
         515                520



<210> 3714
<211> 2083
<212> DNA
<213> Homo sapiens
<308> D21064
<400> 3714

agacgcaag  tggcggctg  ggtgctggc  gcgacgcgg  tgctgcggg  ctcgggttc  60
tggggctgt  cgcggctga  gtttggacc  cctgcgtac  gacggttta  tagtggtgg  120
gcctatccc  acatccccc  ctcttctcc  ttacctgga  tacccaagc  tgtttttgc  180
acagttgat  gacaggaaa  gtttgaaac  aaagtaacc  cattggata  tgggcttcg  240
gtggcatct  agaataagt  tggacagtt  tgtacagta  gaattctta  caattcagg  300
tcgagatat  aagcgaaat  ccttagtgg  attgctcac  ttttggaaa  attggcatt  360
tcgtctact  ctcgatttg  cagcaaaga  gaaattctg  ttacgttgg  aaagcatgg  420
ggtatctgt  actgccaga  atcaagaga  accaccatg  atgctgtgt  tgctgatag  480
aaaggcttg  acacggtgg  tgccttact  gctgatgtg  ttctgcagc  ccggctaac  540
gatgaagaa  tcgagatga  gcggatggc  gtccagttt  agctggagg  cctgaacct  600
cggcctgac  cagagccac  tctcaccga  atgattcat  aagcggctt  cagggagaa  660
acagttggc  tccaccgtt  ctgccccac  gaaaacgta  caaagatca  ccgagaggt  720
ctgcattcc  acctgagga  ctactacac  cccgaccgc  tggtgctgg  cggcgtggg  780
gtggagcac  agcatctgg  ggactgtgc  cggaagtac  tcctggggg  ccagccggc  840
tgggggagc  cagaggccg  ggatattga  agatctgtg  cccagtaca  tggggggat  900
gccaagcta  aaagagaca  gtccaatgt  agcctgggc  cgaccccca  ccccgagct  960
acgcacatc  tggttggac  ggagagctg  tccttcctg  aggaggact  catcccctt  1020
gcagtgttg  acatgatga  gggcggagg  ggctccttc  cggctggtg  gcccggcaa  1080
ggcatgttc  ccaggctct  cctcaacgt  ctcaacagg  accactgga  gtataacgc  1140
acctcctac  accacagct  cgaggacac  ggcctcctt  gcatccatg  cagcgccga  1200
ccaagacag  ttcgagaaa  ggtagaaat  atcacaaag  agtttattt  aatgggcgg  1260
accgtggac  cggtggagc  ggaacgagc  aagacgcag  tgacatcaa  gctcatgat  1320
aacctggaa  ccaggcctg  gatcttcga  gatgtgggg  ggcaggtgc  ggccactcg  1380
tccagaaag  tgccgcacg  gctgtgcac  ctcatccgc  acgtgaagc  ggaagatgt  1440
aagagagtc  cttctaaga  gctccgagg  aagccggca  tggccgccc  gggtgacct  1500
actgacctg  ccacgtatg  ggacatcca  accgccctg  cgagtaagg  cgggcgcct  1560
cccaggacg  accggctct  ccggtagaa  cgctccccg  cctgacaga  ccagggagc  1620
gcagctgga  cccgttccc  tgcgtgtta  tttggacac  aatttagtc  aaaaagctg  1680
ctggttgta  aaacggtgc  aacaatgtc  ccacagcac  cacgcggtt  gcattcttt  1740
ggaactcaa  gtgccgatc  gtggagtca  tatcgagcc  gaccaccgc  agccaggaa  1800
caggtgaag  gcccagcgc  ggagtgcag  gtgccacga  gagggcggt  ggtgcttcc  1860
tcctcgggc  gtgggcaca  ggggccccg  aggttcctt  gaggagccc  gagctggga  1920
gcagcaaag  ctgacctat  aaagcctcc  ggaggccac  gtgctgggt  ccaggactc  1980
cctctgaca  gcaggagaa  gtaagggcc  ggtcagctc  aaggagcgc  ctccacgcg  2040
gtgcacaca  cttccctgg  aataaagag  tggcatctt  ctt  2083



<210> 3715
<211> 525
<212> PRT
<213> Homo sapiens
<308> Q10713
<400> 3715

Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg Gly Ser Gly 
  1               5                  10                  15
Ser Trp Gly Cys Ser Arg Leu Arg Phe Gly Pro Pro Ala Tyr Arg Arg 
             20                  25                  30
Phe Ser Ser Gly Gly Ala Tyr Pro Asn Ile Pro Leu Ser Ser Pro Leu 
         35                  40                  45
Pro Gly Val Pro Lys Pro Val Phe Ala Thr Val Asp Gly Gln Glu Lys 
     50                  55                  60
Phe Glu Thr Lys Val Thr Thr Leu Asp Asn Gly Leu Arg Val Ala Ser 
 65                  70                  75                  80
Gln Asn Lys Phe Gly Gln Phe Cys Thr Val Gly Ile Leu Ile Asn Ser 
                 85                  90                  95
Gly Ser Arg Tyr Glu Ala Lys Tyr Leu Ser Gly Ile Ala His Phe Leu 
             100                105                110
Glu Lys Leu Ala Phe Ser Ser Thr Ala Arg Phe Asp Ser Lys Asp Glu 
         115                120                125
Ile Leu Leu Thr Leu Glu Lys His Gly Gly Ile Cys Asp Cys Gln Thr 
     130                135                140
Ser Arg Asp Thr Thr Met Tyr Ala Val Ser Ala Asp Ser Lys Gly Leu 
 145                150                155                160
Asp Thr Val Val Ala Leu Leu Ala Asp Val Val Leu Gln Pro Arg Leu 
                 165                170                175
Thr Asp Glu Glu Val Glu Met Thr Arg Met Ala Val Gln Phe Glu Leu 
             180                185                190
Glu Asp Leu Asn Leu Arg Pro Asp Pro Glu Pro Leu Leu Thr Glu Met 
         195                200                205
Ile His Glu Ala Ala Tyr Arg Glu Asn Thr Val Gly Leu His Arg Phe 
     210                215                220
Cys Pro Thr Glu Asn Val Ala Lys Ile Asn Arg Glu Val Leu His Ser 
 225                230                235                240
Tyr Leu Arg Asn Tyr Tyr Thr Pro Asp Arg Met Val Leu Ala Gly Val 
                 245                250                255
Gly Val Glu His Glu His Leu Val Asp Cys Ala Arg Lys Tyr Leu Leu 
             260                265                270
Gly Val Gln Pro Ala Trp Gly Ser Ala Glu Ala Val Asp Ile Asp Arg 
         275                280                285
Ser Val Ala Gln Tyr Thr Gly Gly Ile Ala Lys Leu Glu Arg Asp Met 
     290                295                300
Ser Asn Val Ser Leu Gly Pro Thr Pro Ile Pro Glu Leu Thr His Ile 
 305                310                315                320
Met Val Gly Leu Glu Ser Cys Ser Phe Leu Glu Glu Asp Phe Ile Pro 
                 325                330                335
Phe Ala Val Leu Asn Met Met Met Gly Gly Gly Gly Ser Phe Ser Ala 
             340                345                350
Gly Gly Pro Gly Lys Gly Met Phe Ser Arg Leu Tyr Leu Asn Val Leu 
         355                360                365
Asn Arg His His Trp Met Tyr Asn Ala Thr Ser Tyr His His Ser Tyr 
     370                375                380
Glu Asp Thr Gly Leu Leu Cys Ile His Ala Ser Ala Asp Pro Arg Gln 
 385                390                395                400
Val Arg Glu Met Val Glu Ile Ile Thr Lys Glu Phe Ile Leu Met Gly 
                 405                410                415
Gly Thr Val Asp Thr Val Glu Leu Glu Arg Ala Lys Thr Gln Leu Thr 
             420                425                430
Ser Met Leu Met Met Asn Leu Glu Ser Arg Pro Val Ile Phe Glu Asp 
         435                440                445
Val Gly Arg Gln Val Leu Ala Thr Arg Ser Arg Lys Leu Pro His Glu 
     450                455                460
Leu Cys Thr Leu Ile Arg Asn Val Lys Pro Glu Asp Val Lys Arg Val 
 465                470                475                480
Ala Ser Lys Met Leu Arg Gly Lys Pro Ala Val Ala Ala Leu Gly Asp 
                 485                490                495
Leu Thr Asp Leu Pro Thr Tyr Glu Asp Ile Gln Thr Ala Leu Ser Ser 
             500                505                510
Lys Asp Gly Arg Leu Pro Arg Thr Tyr Arg Leu Phe Arg 
         515                520                525



<210> 3716
<211> 1712
<212> DNA
<213> Rattus norvegicus
<308> M57728
<400> 3716

atggcgacg  cagtgtggg  ggctgcgcg  ctacttcgg  gttctgcgg  gctgtgcgc  60
cggcccaag  tcggttctc  tgcacacag  cggttcagc  gtggcgcca  ctaccccaa  120
atccctctc  cttctccct  gcccggagt  cccaagcct  tttttgcta  agttgatgg  180
caggaaaag  ttgaaacca  agtcaccac  ctggacaat  ggcttcgtg  ggcatctca  240
aataagttt  gacagttct  taccttagg  attcttatt  attcaggat  acgatatga  300
gcgaaatat  ttagtggaa  tgctcattt  ctggaaaaa  tggcatttt  gtctaccgc  360
cgatttgac  gcaaagatg  aattctgct  accctggaa  aacatggtg  tatctgtga  420
tgccagacc  cgagagaca  caccatgta  gctgtgtct  ctgacagca  aggcttgga  480
actgtggtg  gcctgctgg  tgatgtggt  ctgcacccc  gcctgacag  tgaggaaat  540
gagatgacg  ggatggctg  tcagtttga  cttgaggac  tgaacatga  acctgaccc  600
gagccactg  tcaccgaga  gattcatga  gctgctttt  gggagaaca  ggtgggcct  660
caccggttt  gtcctgtgg  gaatatcgg  aagattgac  gagaagtgc  gcattccta  720
ctgaagaac  actacaccc  cgaccgcat  gtgcttgct  gagtgggcg  ggagcatga  780
cacctggtc  aatgtgcca  aaagtacct  ctgggagtg  agcctgcct  gggagctcc  840
ggagctgtg  ggatgttga  agctcagtg  cacagtaca  gggggggat  atcaaggtg  900
agagagaca  gtcaaatgt  agccttgcg  ccaccccga  tccagagct  acacatata  960
ggtggggct  gagagctgc  ccttctgga  gaggatttc  tcccctttg  tgtgttgaa  1020
atgatgatg  gaggcgggg  ctccttctc  gccggaggg  ctggcaaag  catgttctc  1080
aggctctac  tcaacgtgc  caatcggca  cactggatg  ataatgcaa  ctcctacca  1140
cacagctat  aagacacag  cctcctgtg  atccatgcc  gcgcagacc  tcgacaggt  1200
cgagaaatg  tagaaatca  cacaaagga  tttattttg  tgggccgaa  ggtggattt  1260
gtggagctg  agcgggcca  gacacagct  atgtccatg  tcatgatga  cttggagtc  1320
aggcctgtg  tctttgagg  tgtggggag  caggtgttg  ctacacatt  aagaaagct  1380
ccccatgag  tgtgcacac  cattcgcaa  gtgaagccg  aagatatca  gagggttgc  1440
tccaagatg  tccgaggca  gcctgctgt  gcggctctg  gtgatttga  tgacctgcc  1500
acgtatgaa  acatccagg  agcgctgtc  agcagagat  ggcgcctgc  cagaacata  1560
cggctgttc  ggtagagcc  tccagcgga  gctgcagag  gcttctgtg  atgttactg  1620
tggtgtgga  actgcataa  aatagctag  tctgtgaac  gtgccaaca  ggaagctct  1680
gaaacttga  tgaaagtta  tgttgccac  gc  1712



<210> 3717
<211> 524
<212> PRT
<213> Rattus norvegicus
<308> P20069
<400> 3717

Met Ala Thr Ala Val Trp Ala Ala Ala Arg Leu Leu Arg Gly Ser Ala 
  1               5                  10                  15
Ala Leu Cys Ala Arg Pro Lys Phe Gly Ser Pro Ala His Arg Arg Phe 
             20                  25                  30
Ser Ser Gly Ala Thr Tyr Pro Asn Ile Pro Leu Ser Ser Pro Leu Pro 
         35                  40                  45
Gly Val Pro Lys Pro Ile Phe Ala Thr Val Asp Gly Gln Glu Lys Phe 
     50                  55                  60
Glu Thr Lys Val Thr Thr Leu Asp Asn Gly Leu Arg Val Ala Ser Gln 
 65                  70                  75                  80
Asn Lys Phe Gly Gln Phe Cys Thr Leu Gly Ile Leu Ile Asn Ser Gly 
                 85                  90                  95
Ser Arg Tyr Glu Ala Lys Tyr Leu Ser Gly Ile Ala His Phe Leu Glu 
             100                105                110
Lys Leu Ala Phe Ser Ser Thr Ala Arg Phe Asp Ser Lys Asp Glu Ile 
         115                120                125
Leu Leu Thr Leu Glu Lys His Gly Gly Ile Cys Asp Cys Gln Thr Ser 
     130                135                140
Arg Asp Thr Thr Met Tyr Ala Val Ser Ala Asp Ser Lys Gly Leu Asp 
 145                150                155                160
Thr Val Val Gly Leu Leu Ala Asp Val Val Leu His Pro Arg Leu Thr 
                 165                170                175
Asp Glu Glu Ile Glu Met Thr Arg Met Ala Val Gln Phe Glu Leu Glu 
             180                185                190
Asp Leu Asn Met Arg Pro Asp Pro Glu Pro Leu Leu Thr Glu Met Ile 
         195                200                205
His Glu Ala Ala Phe Arg Glu Asn Thr Val Gly Leu His Arg Phe Cys 
     210                215                220
Pro Val Glu Asn Ile Gly Lys Ile Asp Arg Glu Val Leu His Ser Tyr 
 225                230                235                240
Leu Lys Asn Tyr Tyr Thr Pro Asp Arg Met Val Leu Ala Gly Val Gly 
                 245                250                255
Val Glu His Glu His Leu Val Glu Cys Ala Arg Lys Tyr Leu Leu Gly 
             260                265                270
Val Gln Pro Ala Trp Gly Ala Pro Gly Ala Val Trp Met Leu Thr Ala 
         275                280                285
Gln Trp His Ser Thr Arg Gly Gly Ser Ser Arg Trp Arg Glu Thr Cys 
     290                295                300
Gln Met Ser Ala Leu Arg Pro Pro Arg Phe Gln Ser Ser His Ile Tyr 
 305                310                315                320
Gly Gly Ala Arg Glu Leu Leu Leu Leu Glu Glu Asp Phe Ile Pro Phe 
                 325                330                335
Ala Val Leu Asn Met Met Met Gly Gly Gly Gly Ser Phe Ser Ala Gly 
             340                345                350
Gly Pro Gly Lys Gly Met Phe Ser Arg Leu Tyr Leu Asn Val Leu Asn 
         355                360                365
Arg His His Trp Met Tyr Asn Ala Thr Ser Tyr His His Ser Tyr Glu 
     370                375                380
Asp Thr Gly Leu Leu Cys Ile His Ala Ser Ala Asp Pro Arg Gln Val 
 385                390                395                400
Arg Glu Met Val Glu Ile Ile Thr Lys Glu Phe Ile Leu Met Gly Arg 
                 405                410                415
Thr Val Asp Leu Val Glu Leu Glu Arg Ala Lys Thr Gln Leu Met Ser 
             420                425                430
Met Leu Met Met Asn Leu Glu Ser Arg Pro Val Ile Phe Glu Asp Val 
         435                440                445
Gly Arg Gln Val Leu Ala Thr His Ser Arg Lys Leu Pro His Glu Leu 
     450                455                460
Cys Thr Leu Ile Arg Asn Val Lys Pro Glu Asp Ile Lys Arg Val Ala 
 465                470                475                480
Ser Lys Met Leu Arg Gly Lys Pro Ala Val Ala Ala Leu Gly Asp Leu 
                 485                490                495
Thr Asp Leu Pro Thr Tyr Glu His Ile Gln Ala Ala Leu Ser Ser Arg 
             500                505                510
Asp Gly Arg Leu Pro Arg Thr Tyr Arg Leu Phe Arg 
         515                520



<210> 3718
<211> 2083
<212> DNA
<213> Homo sapiens
<308> D21064
<400> 3718

agacgcaag  tggcggctg  ggtgctggc  gcgacgcgg  tgctgcggg  ctcgggttc  60
tggggctgt  cgcggctga  gtttggacc  cctgcgtac  gacggttta  tagtggtgg  120
gcctatccc  acatccccc  ctcttctcc  ttacctgga  tacccaagc  tgtttttgc  180
acagttgat  gacaggaaa  gtttgaaac  aaagtaacc  cattggata  tgggcttcg  240
gtggcatct  agaataagt  tggacagtt  tgtacagta  gaattctta  caattcagg  300
tcgagatat  aagcgaaat  ccttagtgg  attgctcac  ttttggaaa  attggcatt  360
tcgtctact  ctcgatttg  cagcaaaga  gaaattctg  ttacgttgg  aaagcatgg  420
ggtatctgt  actgccaga  atcaagaga  accaccatg  atgctgtgt  tgctgatag  480
aaaggcttg  acacggtgg  tgccttact  gctgatgtg  ttctgcagc  ccggctaac  540
gatgaagaa  tcgagatga  gcggatggc  gtccagttt  agctggagg  cctgaacct  600
cggcctgac  cagagccac  tctcaccga  atgattcat  aagcggctt  cagggagaa  660
acagttggc  tccaccgtt  ctgccccac  gaaaacgta  caaagatca  ccgagaggt  720
ctgcattcc  acctgagga  ctactacac  cccgaccgc  tggtgctgg  cggcgtggg  780
gtggagcac  agcatctgg  ggactgtgc  cggaagtac  tcctggggg  ccagccggc  840
tgggggagc  cagaggccg  ggatattga  agatctgtg  cccagtaca  tggggggat  900
gccaagcta  aaagagaca  gtccaatgt  agcctgggc  cgaccccca  ccccgagct  960
acgcacatc  tggttggac  ggagagctg  tccttcctg  aggaggact  catcccctt  1020
gcagtgttg  acatgatga  gggcggagg  ggctccttc  cggctggtg  gcccggcaa  1080
ggcatgttc  ccaggctct  cctcaacgt  ctcaacagg  accactgga  gtataacgc  1140
acctcctac  accacagct  cgaggacac  ggcctcctt  gcatccatg  cagcgccga  1200
ccaagacag  ttcgagaaa  ggtagaaat  atcacaaag  agtttattt  aatgggcgg  1260
accgtggac  cggtggagc  ggaacgagc  aagacgcag  tgacatcaa  gctcatgat  1320
aacctggaa  ccaggcctg  gatcttcga  gatgtgggg  ggcaggtgc  ggccactcg  1380
tccagaaag  tgccgcacg  gctgtgcac  ctcatccgc  acgtgaagc  ggaagatgt  1440
aagagagtc  cttctaaga  gctccgagg  aagccggca  tggccgccc  gggtgacct  1500
actgacctg  ccacgtatg  ggacatcca  accgccctg  cgagtaagg  cgggcgcct  1560
cccaggacg  accggctct  ccggtagaa  cgctccccg  cctgacaga  ccagggagc  1620
gcagctgga  cccgttccc  tgcgtgtta  tttggacac  aatttagtc  aaaaagctg  1680
ctggttgta  aaacggtgc  aacaatgtc  ccacagcac  cacgcggtt  gcattcttt  1740
ggaactcaa  gtgccgatc  gtggagtca  tatcgagcc  gaccaccgc  agccaggaa  1800
caggtgaag  gcccagcgc  ggagtgcag  gtgccacga  gagggcggt  ggtgcttcc  1860
tcctcgggc  gtgggcaca  ggggccccg  aggttcctt  gaggagccc  gagctggga  1920
gcagcaaag  ctgacctat  aaagcctcc  ggaggccac  gtgctgggt  ccaggactc  1980
cctctgaca  gcaggagaa  gtaagggcc  ggtcagctc  aaggagcgc  ctccacgcg  2040
gtgcacaca  cttccctgg  aataaagag  tggcatctt  ctt  2083



<210> 3719
<211> 525
<212> PRT
<213> Homo sapiens
<308> Q10713
<400> 3719

Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg Gly Ser Gly 
  1               5                  10                  15
Ser Trp Gly Cys Ser Arg Leu Arg Phe Gly Pro Pro Ala Tyr Arg Arg 
             20                  25                  30
Phe Ser Ser Gly Gly Ala Tyr Pro Asn Ile Pro Leu Ser Ser Pro Leu 
         35                  40                  45
Pro Gly Val Pro Lys Pro Val Phe Ala Thr Val Asp Gly Gln Glu Lys 
     50                  55                  60
Phe Glu Thr Lys Val Thr Thr Leu Asp Asn Gly Leu Arg Val Ala Ser 
 65                  70                  75                  80
Gln Asn Lys Phe Gly Gln Phe Cys Thr Val Gly Ile Leu Ile Asn Ser 
                 85                  90                  95
Gly Ser Arg Tyr Glu Ala Lys Tyr Leu Ser Gly Ile Ala His Phe Leu 
             100                105                110
Glu Lys Leu Ala Phe Ser Ser Thr Ala Arg Phe Asp Ser Lys Asp Glu 
         115                120                125
Ile Leu Leu Thr Leu Glu Lys His Gly Gly Ile Cys Asp Cys Gln Thr 
     130                135                140
Ser Arg Asp Thr Thr Met Tyr Ala Val Ser Ala Asp Ser Lys Gly Leu 
 145                150                155                160
Asp Thr Val Val Ala Leu Leu Ala Asp Val Val Leu Gln Pro Arg Leu 
                 165                170                175
Thr Asp Glu Glu Val Glu Met Thr Arg Met Ala Val Gln Phe Glu Leu 
             180                185                190
Glu Asp Leu Asn Leu Arg Pro Asp Pro Glu Pro Leu Leu Thr Glu Met 
         195                200                205
Ile His Glu Ala Ala Tyr Arg Glu Asn Thr Val Gly Leu His Arg Phe 
     210                215                220
Cys Pro Thr Glu Asn Val Ala Lys Ile Asn Arg Glu Val Leu His Ser 
 225                230                235                240
Tyr Leu Arg Asn Tyr Tyr Thr Pro Asp Arg Met Val Leu Ala Gly Val 
                 245                250                255
Gly Val Glu His Glu His Leu Val Asp Cys Ala Arg Lys Tyr Leu Leu 
             260                265                270
Gly Val Gln Pro Ala Trp Gly Ser Ala Glu Ala Val Asp Ile Asp Arg 
         275                280                285
Ser Val Ala Gln Tyr Thr Gly Gly Ile Ala Lys Leu Glu Arg Asp Met 
     290                295                300
Ser Asn Val Ser Leu Gly Pro Thr Pro Ile Pro Glu Leu Thr His Ile 
 305                310                315                320
Met Val Gly Leu Glu Ser Cys Ser Phe Leu Glu Glu Asp Phe Ile Pro 
                 325                330                335
Phe Ala Val Leu Asn Met Met Met Gly Gly Gly Gly Ser Phe Ser Ala 
             340                345                350
Gly Gly Pro Gly Lys Gly Met Phe Ser Arg Leu Tyr Leu Asn Val Leu 
         355                360                365
Asn Arg His His Trp Met Tyr Asn Ala Thr Ser Tyr His His Ser Tyr 
     370                375                380
Glu Asp Thr Gly Leu Leu Cys Ile His Ala Ser Ala Asp Pro Arg Gln 
 385                390                395                400
Val Arg Glu Met Val Glu Ile Ile Thr Lys Glu Phe Ile Leu Met Gly 
                 405                410                415
Gly Thr Val Asp Thr Val Glu Leu Glu Arg Ala Lys Thr Gln Leu Thr 
             420                425                430
Ser Met Leu Met Met Asn Leu Glu Ser Arg Pro Val Ile Phe Glu Asp 
         435                440                445
Val Gly Arg Gln Val Leu Ala Thr Arg Ser Arg Lys Leu Pro His Glu 
     450                455                460
Leu Cys Thr Leu Ile Arg Asn Val Lys Pro Glu Asp Val Lys Arg Val 
 465                470                475                480
Ala Ser Lys Met Leu Arg Gly Lys Pro Ala Val Ala Ala Leu Gly Asp 
                 485                490                495
Leu Thr Asp Leu Pro Thr Tyr Glu Asp Ile Gln Thr Ala Leu Ser Ser 
             500                505                510
Lys Asp Gly Arg Leu Pro Arg Thr Tyr Arg Leu Phe Arg 
         515                520                525



<210> 3720
<211> 1712
<212> DNA
<213> Rattus norvegicus
<308> M57728
<400> 3720

atggcgacg  cagtgtggg  ggctgcgcg  ctacttcgg  gttctgcgg  gctgtgcgc  60
cggcccaag  tcggttctc  tgcacacag  cggttcagc  gtggcgcca  ctaccccaa  120
atccctctc  cttctccct  gcccggagt  cccaagcct  tttttgcta  agttgatgg  180
caggaaaag  ttgaaacca  agtcaccac  ctggacaat  ggcttcgtg  ggcatctca  240
aataagttt  gacagttct  taccttagg  attcttatt  attcaggat  acgatatga  300
gcgaaatat  ttagtggaa  tgctcattt  ctggaaaaa  tggcatttt  gtctaccgc  360
cgatttgac  gcaaagatg  aattctgct  accctggaa  aacatggtg  tatctgtga  420
tgccagacc  cgagagaca  caccatgta  gctgtgtct  ctgacagca  aggcttgga  480
actgtggtg  gcctgctgg  tgatgtggt  ctgcacccc  gcctgacag  tgaggaaat  540
gagatgacg  ggatggctg  tcagtttga  cttgaggac  tgaacatga  acctgaccc  600
gagccactg  tcaccgaga  gattcatga  gctgctttt  gggagaaca  ggtgggcct  660
caccggttt  gtcctgtgg  gaatatcgg  aagattgac  gagaagtgc  gcattccta  720
ctgaagaac  actacaccc  cgaccgcat  gtgcttgct  gagtgggcg  ggagcatga  780
cacctggtc  aatgtgcca  aaagtacct  ctgggagtg  agcctgcct  gggagctcc  840
ggagctgtg  ggatgttga  agctcagtg  cacagtaca  gggggggat  atcaaggtg  900
agagagaca  gtcaaatgt  agccttgcg  ccaccccga  tccagagct  acacatata  960
ggtggggct  gagagctgc  ccttctgga  gaggatttc  tcccctttg  tgtgttgaa  1020
atgatgatg  gaggcgggg  ctccttctc  gccggaggg  ctggcaaag  catgttctc  1080
aggctctac  tcaacgtgc  caatcggca  cactggatg  ataatgcaa  ctcctacca  1140
cacagctat  aagacacag  cctcctgtg  atccatgcc  gcgcagacc  tcgacaggt  1200
cgagaaatg  tagaaatca  cacaaagga  tttattttg  tgggccgaa  ggtggattt  1260
gtggagctg  agcgggcca  gacacagct  atgtccatg  tcatgatga  cttggagtc  1320
aggcctgtg  tctttgagg  tgtggggag  caggtgttg  ctacacatt  aagaaagct  1380
ccccatgag  tgtgcacac  cattcgcaa  gtgaagccg  aagatatca  gagggttgc  1440
tccaagatg  tccgaggca  gcctgctgt  gcggctctg  gtgatttga  tgacctgcc  1500
acgtatgaa  acatccagg  agcgctgtc  agcagagat  ggcgcctgc  cagaacata  1560
cggctgttc  ggtagagcc  tccagcgga  gctgcagag  gcttctgtg  atgttactg  1620
tggtgtgga  actgcataa  aatagctag  tctgtgaac  gtgccaaca  ggaagctct  1680
gaaacttga  tgaaagtta  tgttgccac  gc  1712



<210> 3721
<211> 524
<212> PRT
<213> Rattus norvegicus
<308> P20069
<400> 3721

Met Ala Thr Ala Val Trp Ala Ala Ala Arg Leu Leu Arg Gly Ser Ala 
  1               5                  10                  15
Ala Leu Cys Ala Arg Pro Lys Phe Gly Ser Pro Ala His Arg Arg Phe 
             20                  25                  30
Ser Ser Gly Ala Thr Tyr Pro Asn Ile Pro Leu Ser Ser Pro Leu Pro 
         35                  40                  45
Gly Val Pro Lys Pro Ile Phe Ala Thr Val Asp Gly Gln Glu Lys Phe 
     50                  55                  60
Glu Thr Lys Val Thr Thr Leu Asp Asn Gly Leu Arg Val Ala Ser Gln 
 65                  70                  75                  80
Asn Lys Phe Gly Gln Phe Cys Thr Leu Gly Ile Leu Ile Asn Ser Gly 
                 85                  90                  95
Ser Arg Tyr Glu Ala Lys Tyr Leu Ser Gly Ile Ala His Phe Leu Glu 
             100                105                110
Lys Leu Ala Phe Ser Ser Thr Ala Arg Phe Asp Ser Lys Asp Glu Ile 
         115                120                125
Leu Leu Thr Leu Glu Lys His Gly Gly Ile Cys Asp Cys Gln Thr Ser 
     130                135                140
Arg Asp Thr Thr Met Tyr Ala Val Ser Ala Asp Ser Lys Gly Leu Asp 
 145                150                155                160
Thr Val Val Gly Leu Leu Ala Asp Val Val Leu His Pro Arg Leu Thr 
                 165                170                175
Asp Glu Glu Ile Glu Met Thr Arg Met Ala Val Gln Phe Glu Leu Glu 
             180                185                190
Asp Leu Asn Met Arg Pro Asp Pro Glu Pro Leu Leu Thr Glu Met Ile 
         195                200                205
His Glu Ala Ala Phe Arg Glu Asn Thr Val Gly Leu His Arg Phe Cys 
     210                215                220
Pro Val Glu Asn Ile Gly Lys Ile Asp Arg Glu Val Leu His Ser Tyr 
 225                230                235                240
Leu Lys Asn Tyr Tyr Thr Pro Asp Arg Met Val Leu Ala Gly Val Gly 
                 245                250                255
Val Glu His Glu His Leu Val Glu Cys Ala Arg Lys Tyr Leu Leu Gly 
             260                265                270
Val Gln Pro Ala Trp Gly Ala Pro Gly Ala Val Trp Met Leu Thr Ala 
         275                280                285
Gln Trp His Ser Thr Arg Gly Gly Ser Ser Arg Trp Arg Glu Thr Cys 
     290                295                300
Gln Met Ser Ala Leu Arg Pro Pro Arg Phe Gln Ser Ser His Ile Tyr 
 305                310                315                320
Gly Gly Ala Arg Glu Leu Leu Leu Leu Glu Glu Asp Phe Ile Pro Phe 
                 325                330                335
Ala Val Leu Asn Met Met Met Gly Gly Gly Gly Ser Phe Ser Ala Gly 
             340                345                350
Gly Pro Gly Lys Gly Met Phe Ser Arg Leu Tyr Leu Asn Val Leu Asn 
         355                360                365
Arg His His Trp Met Tyr Asn Ala Thr Ser Tyr His His Ser Tyr Glu 
     370                375                380
Asp Thr Gly Leu Leu Cys Ile His Ala Ser Ala Asp Pro Arg Gln Val 
 385                390                395                400
Arg Glu Met Val Glu Ile Ile Thr Lys Glu Phe Ile Leu Met Gly Arg 
                 405                410                415
Thr Val Asp Leu Val Glu Leu Glu Arg Ala Lys Thr Gln Leu Met Ser 
             420                425                430
Met Leu Met Met Asn Leu Glu Ser Arg Pro Val Ile Phe Glu Asp Val 
         435                440                445
Gly Arg Gln Val Leu Ala Thr His Ser Arg Lys Leu Pro His Glu Leu 
     450                455                460
Cys Thr Leu Ile Arg Asn Val Lys Pro Glu Asp Ile Lys Arg Val Ala 
 465                470                475                480
Ser Lys Met Leu Arg Gly Lys Pro Ala Val Ala Ala Leu Gly Asp Leu 
                 485                490                495
Thr Asp Leu Pro Thr Tyr Glu His Ile Gln Ala Ala Leu Ser Ser Arg 
             500                505                510
Asp Gly Arg Leu Pro Arg Thr Tyr Arg Leu Phe Arg 
         515                520



<210> 3722
<211> 2083
<212> DNA
<213> Homo sapiens
<308> D21064
<400> 3722

agacgcaag  tggcggctg  ggtgctggc  gcgacgcgg  tgctgcggg  ctcgggttc  60
tggggctgt  cgcggctga  gtttggacc  cctgcgtac  gacggttta  tagtggtgg  120
gcctatccc  acatccccc  ctcttctcc  ttacctgga  tacccaagc  tgtttttgc  180
acagttgat  gacaggaaa  gtttgaaac  aaagtaacc  cattggata  tgggcttcg  240
gtggcatct  agaataagt  tggacagtt  tgtacagta  gaattctta  caattcagg  300
tcgagatat  aagcgaaat  ccttagtgg  attgctcac  ttttggaaa  attggcatt  360
tcgtctact  ctcgatttg  cagcaaaga  gaaattctg  ttacgttgg  aaagcatgg  420
ggtatctgt  actgccaga  atcaagaga  accaccatg  atgctgtgt  tgctgatag  480
aaaggcttg  acacggtgg  tgccttact  gctgatgtg  ttctgcagc  ccggctaac  540
gatgaagaa  tcgagatga  gcggatggc  gtccagttt  agctggagg  cctgaacct  600
cggcctgac  cagagccac  tctcaccga  atgattcat  aagcggctt  cagggagaa  660
acagttggc  tccaccgtt  ctgccccac  gaaaacgta  caaagatca  ccgagaggt  720
ctgcattcc  acctgagga  ctactacac  cccgaccgc  tggtgctgg  cggcgtggg  780
gtggagcac  agcatctgg  ggactgtgc  cggaagtac  tcctggggg  ccagccggc  840
tgggggagc  cagaggccg  ggatattga  agatctgtg  cccagtaca  tggggggat  900
gccaagcta  aaagagaca  gtccaatgt  agcctgggc  cgaccccca  ccccgagct  960
acgcacatc  tggttggac  ggagagctg  tccttcctg  aggaggact  catcccctt  1020
gcagtgttg  acatgatga  gggcggagg  ggctccttc  cggctggtg  gcccggcaa  1080
ggcatgttc  ccaggctct  cctcaacgt  ctcaacagg  accactgga  gtataacgc  1140
acctcctac  accacagct  cgaggacac  ggcctcctt  gcatccatg  cagcgccga  1200
ccaagacag  ttcgagaaa  ggtagaaat  atcacaaag  agtttattt  aatgggcgg  1260
accgtggac  cggtggagc  ggaacgagc  aagacgcag  tgacatcaa  gctcatgat  1320
aacctggaa  ccaggcctg  gatcttcga  gatgtgggg  ggcaggtgc  ggccactcg  1380
tccagaaag  tgccgcacg  gctgtgcac  ctcatccgc  acgtgaagc  ggaagatgt  1440
aagagagtc  cttctaaga  gctccgagg  aagccggca  tggccgccc  gggtgacct  1500
actgacctg  ccacgtatg  ggacatcca  accgccctg  cgagtaagg  cgggcgcct  1560
cccaggacg  accggctct  ccggtagaa  cgctccccg  cctgacaga  ccagggagc  1620
gcagctgga  cccgttccc  tgcgtgtta  tttggacac  aatttagtc  aaaaagctg  1680
ctggttgta  aaacggtgc  aacaatgtc  ccacagcac  cacgcggtt  gcattcttt  1740
ggaactcaa  gtgccgatc  gtggagtca  tatcgagcc  gaccaccgc  agccaggaa  1800
caggtgaag  gcccagcgc  ggagtgcag  gtgccacga  gagggcggt  ggtgcttcc  1860
tcctcgggc  gtgggcaca  ggggccccg  aggttcctt  gaggagccc  gagctggga  1920
gcagcaaag  ctgacctat  aaagcctcc  ggaggccac  gtgctgggt  ccaggactc  1980
cctctgaca  gcaggagaa  gtaagggcc  ggtcagctc  aaggagcgc  ctccacgcg  2040
gtgcacaca  cttccctgg  aataaagag  tggcatctt  ctt  2083



<210> 3723
<211> 525
<212> PRT
<213> Homo sapiens
<308> Q10713
<400> 3723

Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg Gly Ser Gly 
  1               5                  10                  15
Ser Trp Gly Cys Ser Arg Leu Arg Phe Gly Pro Pro Ala Tyr Arg Arg 
             20                  25                  30
Phe Ser Ser Gly Gly Ala Tyr Pro Asn Ile Pro Leu Ser Ser Pro Leu 
         35                  40                  45
Pro Gly Val Pro Lys Pro Val Phe Ala Thr Val Asp Gly Gln Glu Lys 
     50                  55                  60
Phe Glu Thr Lys Val Thr Thr Leu Asp Asn Gly Leu Arg Val Ala Ser 
 65                  70                  75                  80
Gln Asn Lys Phe Gly Gln Phe Cys Thr Val Gly Ile Leu Ile Asn Ser 
                 85                  90                  95
Gly Ser Arg Tyr Glu Ala Lys Tyr Leu Ser Gly Ile Ala His Phe Leu 
             100                105                110
Glu Lys Leu Ala Phe Ser Ser Thr Ala Arg Phe Asp Ser Lys Asp Glu 
         115                120                125
Ile Leu Leu Thr Leu Glu Lys His Gly Gly Ile Cys Asp Cys Gln Thr 
     130                135                140
Ser Arg Asp Thr Thr Met Tyr Ala Val Ser Ala Asp Ser Lys Gly Leu 
 145                150                155                160
Asp Thr Val Val Ala Leu Leu Ala Asp Val Val Leu Gln Pro Arg Leu 
                 165                170                175
Thr Asp Glu Glu Val Glu Met Thr Arg Met Ala Val Gln Phe Glu Leu 
             180                185                190
Glu Asp Leu Asn Leu Arg Pro Asp Pro Glu Pro Leu Leu Thr Glu Met 
         195                200                205
Ile His Glu Ala Ala Tyr Arg Glu Asn Thr Val Gly Leu His Arg Phe 
     210                215                220
Cys Pro Thr Glu Asn Val Ala Lys Ile Asn Arg Glu Val Leu His Ser 
 225                230                235                240
Tyr Leu Arg Asn Tyr Tyr Thr Pro Asp Arg Met Val Leu Ala Gly Val 
                 245                250                255
Gly Val Glu His Glu His Leu Val Asp Cys Ala Arg Lys Tyr Leu Leu 
             260                265                270
Gly Val Gln Pro Ala Trp Gly Ser Ala Glu Ala Val Asp Ile Asp Arg 
         275                280                285
Ser Val Ala Gln Tyr Thr Gly Gly Ile Ala Lys Leu Glu Arg Asp Met 
     290                295                300
Ser Asn Val Ser Leu Gly Pro Thr Pro Ile Pro Glu Leu Thr His Ile 
 305                310                315                320
Met Val Gly Leu Glu Ser Cys Ser Phe Leu Glu Glu Asp Phe Ile Pro 
                 325                330                335
Phe Ala Val Leu Asn Met Met Met Gly Gly Gly Gly Ser Phe Ser Ala 
             340                345                350
Gly Gly Pro Gly Lys Gly Met Phe Ser Arg Leu Tyr Leu Asn Val Leu 
         355                360                365
Asn Arg His His Trp Met Tyr Asn Ala Thr Ser Tyr His His Ser Tyr 
     370                375                380
Glu Asp Thr Gly Leu Leu Cys Ile His Ala Ser Ala Asp Pro Arg Gln 
 385                390                395                400
Val Arg Glu Met Val Glu Ile Ile Thr Lys Glu Phe Ile Leu Met Gly 
                 405                410                415
Gly Thr Val Asp Thr Val Glu Leu Glu Arg Ala Lys Thr Gln Leu Thr 
             420                425                430
Ser Met Leu Met Met Asn Leu Glu Ser Arg Pro Val Ile Phe Glu Asp 
         435                440                445
Val Gly Arg Gln Val Leu Ala Thr Arg Ser Arg Lys Leu Pro His Glu 
     450                455                460
Leu Cys Thr Leu Ile Arg Asn Val Lys Pro Glu Asp Val Lys Arg Val 
 465                470                475                480
Ala Ser Lys Met Leu Arg Gly Lys Pro Ala Val Ala Ala Leu Gly Asp 
                 485                490                495
Leu Thr Asp Leu Pro Thr Tyr Glu Asp Ile Gln Thr Ala Leu Ser Ser 
             500                505                510
Lys Asp Gly Arg Leu Pro Arg Thr Tyr Arg Leu Phe Arg 
         515                520                525



<210> 3724
<211> 1016
<212> DNA
<213> Rattus norvegicus
<308> M58364
<400> 3724

gacttcgaa  ctcattcgg  gcagaactc  tgtcccggt  acagccaca  gtcacggcc  60
ccggctaag  cgagccgca  cgcttggta  caccttagg  tgtctcggg  gcaatcgcg  120
cgggtccat  gagaagccg  ggggtgtaa  gtgcaccaa  gggttcccc  agcgggagc  180
gccgcggcc  ggggccagc  gacctgccg  gaagtcccg  ccgcccgag  ccaagggcg  240
acagccagc  gacgcctgg  aggcagggc  gccccgcag  gaggaggat  acgagctga  300
cctccccaa  ctggcggcc  cttactcgt  catcctgcg  tcgctgggc  aggaccccc  360
gcggcaggg  ctgctcaag  cgccctgga  ggcggccac  gccatgcag  tcttcacca  420
gggatacca  gagaccatc  cagatgtcc  gaacgatgc  atatttgat  aggaccatg  480
cgagatggt  attgtgaag  acattgaca  gttttccat  tgtgagcat  acctggtcc  540
atttgtggg  agggtccat  ttggttatc  tcctaacaa  caagtcctt  gtctcagca  600
acttgccag  attgtggaa  tctacagta  aagactaca  gttcaagaa  gccttacca  660
acagattgc  gtggccatc  cagaagcct  gcagcctgc  ggcgtcggg  tagtgattg  720
agcaacaca  atgtgtatg  tcatgcgag  tgtgcagaa  atgaacagc  agactgtca  780
tagcaccat  ctaggcgtg  tccgggaag  cccaaagac  cgggaggag  tcctcacac  840
catcaggag  tgaacttcc  tgtgcgagc  ccggtttgc  gacccccgc  gaggccagc  900
ttatctgtc  cgattgtac  ttccagttc  agttggtat  cttgtcaac  ttatttctc  960
ccatgaatt  tatttaata  ttatttata  agatgtcaa  taaaggtga  caactt  1016



<210> 3725
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> P22288
<400> 3725

Met Glu Lys Pro Arg Gly Val Arg Cys Thr Asn Gly Phe Pro Glu Arg 
  1               5                  10                  15
Glu Leu Pro Arg Pro Gly Ala Ser Arg Pro Ala Glu Lys Ser Arg Pro 
             20                  25                  30
Pro Glu Ala Lys Gly Ala Gln Pro Ala Asp Ala Trp Lys Ala Gly Arg 
         35                  40                  45
Pro Arg Ser Glu Glu Asp Asn Glu Leu Asn Leu Pro Asn Leu Ala Ala 
     50                  55                  60
Ala Tyr Ser Ser Ile Leu Arg Ser Leu Gly Glu Asp Pro Gln Arg Gln 
 65                  70                  75                  80
Gly Leu Leu Lys Thr Pro Trp Arg Ala Ala Thr Ala Met Gln Phe Phe 
                 85                  90                  95
Thr Lys Gly Tyr Gln Glu Thr Ile Ser Asp Val Leu Asn Asp Ala Ile 
             100                105                110
Phe Asp Glu Asp His Asp Glu Met Val Ile Val Lys Asp Ile Asp Met 
         115                120                125
Phe Ser Met Cys Glu His His Leu Val Pro Phe Val Gly Arg Val His 
     130                135                140
Ile Gly Tyr Leu Pro Asn Lys Gln Val Leu Gly Leu Ser Lys Leu Ala 
 145                150                155                160
Arg Ile Val Glu Ile Tyr Ser Arg Arg Leu Gln Val Gln Glu Arg Leu 
                 165                170                175
Thr Lys Gln Ile Ala Val Ala Ile Thr Glu Ala Leu Gln Pro Ala Gly 
             180                185                190
Val Gly Val Val Ile Glu Ala Thr His Met Cys Met Val Met Arg Gly 
         195                200                205
Val Gln Lys Met Asn Ser Lys Thr Val Thr Ser Thr Met Leu Gly Val 
     210                215                220
Phe Arg Glu Asp Pro Lys Thr Arg Glu Glu Phe Leu Thr Leu Ile Arg 
 225                230                235                240
Ser 
                 245



<210> 3726
<211> 1413
<212> DNA
<213> Homo sapiens
<308> U63810
<400> 3726

ggtgagttt  cggggcgac  caggtcctc  ggcggaacg  ggagcctct  tcggccgcg  60
aagcctgga  tgggcggta  gcagacgcg  gcggcgaga  ccgctgtct  ctcagcgga  120
tctgcccgc  cccacctcc  cctgcgtcg  gccgacatg  aggactcgc  ggtgctgct  180
ggccgtgtc  cggcgcacc  ggactcccg  tgctggttc  tggcctgga  ccccgcggg  240
accctgctg  cctcgtgcg  cggcgaccg  agaatccgc  tctggggca  ggagggtga  300
agctggatc  gcaagtctg  cctttctga  ggccaccag  gcaccgtgc  gaaggtagc  360
tggtccccc  gcggtaatt  cctggcctc  gccagcttt  atgctacca  ttgcatttg  420
aagaagaac  aggatgact  tgagtgtgt  accactctc  agggccatg  aaatgaggt  480
aagtcagtg  cttgggccc  atctggcaa  ctcctggcc  cttgcagcc  agataagag  540
gtttgggtc  gggaagttg  tgaagagga  gagtatgaa  gtgtcagtg  tctcaactc  600
cacacacag  atgtcaagc  tgtggtttg  cacccaagt  aggagctct  agcttctgc  660
agctatgat  acacagtga  gctgtaccg  gaggaagag  atgactggg  atgctgtgc  720
acccttgag  gccatgaat  cactgtgtg  agcttggcc  ttgacccga  tggccagcg  780
ctggcgtct  gtagtgatg  ccgtactgt  cgtatctgg  gtcagtatc  accaggcaa  840
gaacaaggg  tggcatgca  cggctctga  cccagttgg  aatgtatct  tactttgtc  900
ggcttccac  caaggacca  ttatgacat  gcttggtgt  agctgacag  ggctctggc  960
acagcttgt  gggatgacg  gatccgcgt  tttcaggag  atcccaact  ggatccaca  1020
cagcccacc  tctccctga  agcccactt  catcaggcc  attcccagg  tgtcaactg  1080
gtggcctgg  accccaagg  gccagggct  ctggcctcc  gcagtgatg  tggggaggt  1140
gccttctgg  agtatcagc  gcctgaagg  ctctgagct  ccacgtctt  ggacagagt  1200
atgactccc  agaaaacgt  atataagac  tttaccagc  cctgagagg  ccaggagga  1260
catccttga  cttcattta  cttggctca  ttctcttca  acttgggta  aagtgcaga  1320
ccacagaat  gctttcctt  cccgccttt  acatgaggc  ttcagtaaa  agctacaga  1380
catgaaaaa  aaaaaaaaa  aaaaaaaaa  aaa  1413



<210> 3727
<211> 339
<212> PRT
<213> Homo sapiens
<308> O76071
<400> 3727

Met Lys Asp Ser Leu Val Leu Leu Gly Arg Val Pro Ala His Pro Asp 
  1               5                  10                  15
Ser Arg Cys Trp Phe Leu Ala Trp Asn Pro Ala Gly Thr Leu Leu Ala 
             20                  25                  30
Ser Cys Gly Gly Asp Arg Arg Ile Arg Ile Trp Gly Thr Glu Gly Asp 
         35                  40                  45
Ser Trp Ile Cys Lys Ser Val Leu Ser Glu Gly His Gln Arg Thr Val 
     50                  55                  60
Arg Lys Val Ala Trp Ser Pro Cys Gly Asn Tyr Leu Ala Ser Ala Ser 
 65                  70                  75                  80
Phe Asp Ala Thr Thr Cys Ile Trp Lys Lys Asn Gln Asp Asp Phe Glu 
                 85                  90                  95
Cys Val Thr Thr Leu Glu Gly His Glu Asn Glu Val Lys Ser Val Ala 
             100                105                110
Trp Ala Pro Ser Gly Asn Leu Leu Ala Thr Cys Ser Arg Asp Lys Ser 
         115                120                125
Val Trp Val Trp Glu Val Asp Glu Glu Asp Glu Tyr Glu Cys Val Ser 
     130                135                140
Val Leu Asn Ser His Thr Gln Asp Val Lys His Val Val Trp His Pro 
 145                150                155                160
Ser Gln Glu Leu Leu Ala Ser Ala Ser Tyr Asp Asp Thr Val Lys Leu 
                 165                170                175
Tyr Arg Glu Glu Glu Asp Asp Trp Val Cys Cys Ala Thr Leu Glu Gly 
             180                185                190
His Glu Ser Thr Val Trp Ser Leu Ala Phe Asp Pro Ser Gly Gln Arg 
         195                200                205
Leu Ala Ser Cys Ser Asp Asp Arg Thr Val Arg Ile Trp Arg Gln Tyr 
     210                215                220
Leu Pro Gly Asn Glu Gln Gly Val Ala Cys Ser Gly Ser Asp Pro Ser 
 225                230                235                240
Trp Lys Cys Ile Cys Thr Leu Ser Gly Phe His Ser Arg Thr Ile Tyr 
                 245                250                255
Asp Ile Ala Trp Cys Gln Leu Thr Gly Ala Leu Ala Thr Ala Cys Gly 
             260                265                270
Asp Asp Ala Ile Arg Val Phe Gln Glu Asp Pro Asn Ser Asp Pro Gln 
         275                280                285
Gln Pro Thr Phe Ser Leu Thr Ala His Leu His Gln Ala His Ser Gln 
     290                295                300
Asp Val Asn Cys Val Ala Trp Asn Pro Lys Glu Pro Gly Leu Leu Ala 
 305                310                315                320
Ser Cys Ser Asp Asp Gly Glu Val Ala Phe Trp Lys Tyr Gln Arg Pro 
                 325                330                335
Glu Gly Leu 
             340



<210> 3728
<211> 492
<212> DNA
<213> Rattus norvegicus
<308> M58370
<400> 3728

ggccttctg  catcctggc  tcgcccagc  cccatccac  ccagccgta  cagtcacca  60
gaaggtcct  gttgttctg  ttgtaaccc  cgttgccgt  gcctatgca  ctcctggac  120
ccggggtct  tttatcaac  tggaggacg  tgagatctg  gtaaacagt  tgcagtgta  180
gagcagatg  tgccaacat  acaccatcc  gggcatcgc  cggtgcaca  acaaggcca  240
ggagaacag  gagtgctcc  caaagaccc  ctatgggat  tactacagg  gtccctgtg  300
gcggggcct  acctgtgag  gggacagga  catcattgg  gccatcacc  acaccaact  360
cggcgtctg  ctcgactcc  cccgctcca  gcagtgaga  cgtgcagtg  gctgggcca  420
ctctccctt  cccttcact  gccccatct  agtcaccca  tggcaatta  agcccattg  480
aaccttaaa  aa  492



<210> 3729
<211> 112
<212> PRT
<213> Rattus norvegicus
<308> P17084
<400> 3729

Met Lys Val Leu Val Val Leu Leu Val Thr Leu Val Ala Val Ala Tyr 
  1               5                  10                  15
Ala Val Pro Gly Pro Arg Gly Leu Phe Ile Asn Leu Glu Asp Gly Glu 
             20                  25                  30
Ile Cys Val Asn Ser Met Gln Cys Lys Ser Arg Cys Cys Gln His Asp 
         35                  40                  45
Thr Ile Leu Gly Ile Ala Arg Cys Thr His Lys Ala Met Glu Asn Ser 
     50                  55                  60
Glu Cys Ser Pro Lys Thr Leu Tyr Gly Ile Tyr Tyr Arg Cys Pro Cys 
 65                  70                  75                  80
Glu Arg Gly Leu Thr Cys Glu Gly Asp Arg Ser Ile Ile Gly Ala Ile 
                 85                  90                  95
Thr Asn Thr Asn Tyr Gly Val Cys Leu Asp Ser Thr Arg Ser Lys Gln 
             100                105                110



<210> 3730
<211> 485
<212> DNA
<213> Homo sapiens
<308> BG311131
<400> 3730

ttccagctt  catccaccc  agctttacc  gacaccatg  agaaggtcc  tgttcttct  60
cttgtgtcc  tccttgcag  ggcctatgc  gctcccgga  cccggggtc  tattatcaa  120
ctgaatgac  gtgagatct  tttgaacag  atgcagtgt  agagcagat  ctgccaaca  180
gacaccatc  tgggcattg  ccgttgcac  cacaaggcc  tggagaaca  cgagtgctc  240
ccaaagacc  tctatggga  ctactaccg  tgtccctgt  agcggggcc  gacctgtga  300
ggggacagg  gcatcatcg  cgccatcac  aacaccaac  atggcatct  cctcgactc  360
aggcgctcc  agcagtgag  tcacgcagt  agctgggtt  taccttctt  tctttctcc  420
tctgtccca  ctgagccag  cagctgttg  caattaaaa  ccacttgca  ccttaaaaa  480
aaaaa  485



<210> 3731
<211> 112
<212> PRT
<213> Homo sapiens
<308> NP_001823
<400> 3731

Met Glu Lys Ile Leu Ile Leu Leu Leu Val Ala Leu Ser Val Ala Tyr 
  1               5                  10                  15
Ala Ala Pro Gly Pro Arg Gly Ile Ile Ile Asn Leu Glu Asn Gly Glu 
             20                  25                  30
Leu Cys Met Asn Ser Ala Gln Cys Lys Ser Asn Cys Cys Gln His Ser 
         35                  40                  45
Ser Ala Leu Gly Leu Ala Arg Cys Thr Ser Met Ala Ser Glu Asn Ser 
     50                  55                  60
Glu Cys Ser Val Lys Thr Leu Tyr Gly Ile Tyr Tyr Lys Cys Pro Cys 
 65                  70                  75                  80
Glu Arg Gly Leu Thr Cys Glu Gly Asp Lys Thr Ile Val Gly Ser Ile 
                 85                  90                  95
Thr Asn Thr Asn Phe Gly Ile Cys His Asp Ala Gly Arg Ser Lys Gln 
             100                105                110



<210> 3732
<211> 15627
<212> DNA
<213> Rattus norvegicus
<308> M60322
<400> 3732

ggatccagg  agttcaaat  gcagagaag  ctctatgcc  agagggatt  cacagagga  60
aagtggcgg  tgtcaggtc  cctgttatc  tacacaaac  taatcccca  cactacact  120
aaattcaaa  tctactatt  agagaaaaa  tacacaaga  cttccacat  ccaacagct  180
tggggtttt  ttttgttaa  aaaatccaa  tggaaaata  ctgttcttt  taaattttc  240
cagggatgg  agtggaaga  tgccacctt  taggagggc  ccaactgga  aatcaccag  300
atggcactt  gagaggtgg  gttcctgac  cattactct  cagatgcag  tgtctgtgt  360
gcataatca  gggggcgac  gaagcatga  ccagcagaa  gagactcag  caaaacaga  420
catcacgca  aggggtgtt  gaagagtgc  aaatttccg  cattgttct  ggggcaact  480
cgattattt  agggaaagt  tttgttttt  tacccaata  caactgatt  atttatttt  540
tgtcccctt  acttggaat  attgctgta  gaaaacgga  ttttcctag  atgggattc  600
gcctgttca  ttttcttcc  gagagagtt  ggtcaactt  ctatactgg  acctgcccg  660
tcaacagtt  tactttccc  aatcattta  gtgtgatcc  gagatcaag  ttatgaggg  720
ttatagcta  cggttgctg  gtttcgcat  aaggcttgt  gaaccagat  gagcatgtt  780
agacactgg  aatggtaga  agctactac  agcgggcat  ttgtagtat  ttgcaaagc  840
ggttacaat  atttcaatt  agggggctg  gggaggggg  ggcttaaat  cacctgaag  900
ttaactttt  acataagac  aaaaaaaaa  aaaaaaaaa  aaaaaaagc  cttaagtac  960
cctgacgcc  atctgctcc  tcagtttca  aacaagatg  gcaggattc  agaagagta  1020
tattctgag  ttagaaaaa  acacaagcg  ctttttctg  cctctaaaa  gaaaccaaa  1080
ccttttccc  gtctcctta  ctctagtct  ccggttatt  tcagagcgt  tagtctggt  1140
cttcaacag  aggcaaaca  tctgccacg  ggggcgcag  gcagctgga  aattccgtg  1200
ctctaggac  tagggaaag  agcatcctc  ctgaccctt  aaggaccac  gaagagacc  1260
atcagaagg  gccgtctct  agccgtgcg  caatcgcag  cgtcctttc  gcaggctgt  1320
ggggctatt  aaaggtgcg  gccggagcc  gcgctgcac  cttgcgggt  gttgtgcgt  1380
acttgcagc  atcatggct  gccatctgg  actcaacaa  ggcaccaag  tgcccaccc  1440
gggtctggg  acctggaag  taggtgctc  tcagggcgt  gcccgccac  cgctgggtg  1500
ccctgagcg  cctgcgcgg  gcggggctc  ggtggttgg  gcctgtggg  gcatccggc  1560
gcggccccg  gtgtggggc  ctgggcgag  attgcgcga  tccgcgtgg  tgccccagg  1620
ggagacaca  ccacggggg  gagaggaac  gaagcaggg  tctagattt  tcatctggc  1680
ccccaaact  acgagtgag  tgacctcac  tggagcaga  gttgccctc  cgggaatga  1740
ccacttggc  gataggcct  agataatta  attaggagg  gagagtttg  agtgaacca  1800
cctgtttct  ttttcctta  atcgctgag  gcagctctt  acgggtgcg  aactcctct  1860
gaattaatc  ggtttccgc  ttgctgggt  ccaccctcc  caaacccca  cacaacaca  1920
caggcttga  aagacggcc  gatacgtta  agtgaaata  aaaaagaaa  aaccgataa  1980
taaaaacta  aaattataa  tgatttgat  atttgaaaa  taaggaacc  gttttggtg  2040
tattgctga  gcagaaaaa  ccagctctt  agctactgc  gtgacctgg  tctttaaga  2100
cctggagta  gggtgaacc  gggctgtat  taagcactt  gacacagtg  aggaaagag  2160
aaatcatgc  gggttgagt  cagatggtt  gaaactgga  agtctgttt  tacccagac  2220
acagttaaa  tgggtaatg  atatggtga  taagaaaca  gtcatagac  tgtctttct  2280
tgaatgtgt  tctaagcca  tagattagc  agtgcggct  tcgtttcct  ccaaagggt  2340
cttggtgac  gtaaagatg  gattgaatg  gaaccatca  accagatta  attctatgc  2400
ttggaagga  aagaaagat  gtttccttg  tgtaataaa  acagcacag  aaaggcaca  2460
ataactaca  tggttttgt  atacacgac  ctcaacatg  gtgggatgc  gatacttta  2520
ttctgtccc  tttctctaa  aaccaagct  ataacttta  aaaagcatt  tgagatcag  2580
tctcgggta  acacgagta  acattcata  gccggtggc  agagcggat  caacagccc  2640
agagagctg  gtgtttgtt  aaaattaca  acattttaa  gtatagatc  ttctgccgc  2700
ttcacagat  ttcctgtca  ttcccgcag  gcctggctt  tagaatgga  ccagaagtc  2760
tgttgagtt  gggcagggt  aagaaaatg  ctgcctgtg  ctgggggca  ggggaggtt  2820
gtgcagaga  cgtggaggg  cgaagggtg  cagtgagag  caggaggac  gccgagact  2880
ccagatttc  ttttttttt  ttttttttt  tttggttct  tttttttcg  agctgggga  2940
cgaacccag  gccttgcgc  tcctaggca  gcgctctac  actgagcta  atccccagc  3000
cccagattt  cctttttaa  aaaagaata  caacttaat  ctttccttg  acatgtgtg  3060
cgttccttc  tagatgaca  agtatatca  agtcactgt  atggtcaca  agggtgtgt  3120
ggtgcggtc  cttgttctg  aacttcatc  gtggccacc  ggtacctca  agaccacag  3180
gggactctg  cagggtatg  tccactctt  ccttgaggg  atctgtttc  cctgggagg  3240
gaggatttg  ggcagttgg  agacactct  acttgcatg  actttcttc  tggccaact  3300
gcctgccct  tggaccccc  aaatgcatg  taaatatac  atattacat  aaaatactg  3360
tttaagttt  gtgtggtca  gaggccttt  aggcagagc  ggcctgata  agaccacca  3420
gccctttta  tgataatgt  ttgacctag  tgaaaatct  tgaaggaca  ggccattgt  3480
tcttccaca  ataggctag  aattgctgc  aggaatgta  ggacagctg  gttctcaga  3540
tattttcca  ttaatgccc  ctgtgcctc  aaaccatga  tctcttgag  tgaactttt  3600
ttttctttt  ggcctaatt  tatcccaat  ggattctgg  atctcagat  aaactacta  3660
atatgtgct  acgccctgt  ttccctttc  cagggtcac  tggcattct  aagctgtga  3720
atattttct  tgcttgctt  ttgagtgtg  tttttgcct  tctgggata  tagtacttg  3780
ccttagaag  aaactgtgc  agggtcctc  tgccatttc  tgagttaaa  caagtgtcc  3840
ctgacagtc  tagagcctg  ggtcaggga  aaatgctgt  ctcattgaa  taggagttt  3900
gttttctgg  ggcctgcca  tgaccaggc  acactcctc  acctttcca  atttaagat  3960
aaaaaaaaa  atcaaatat  tcttgtcta  gcagggccg  tcctggagc  acatctctg  4020
ggagtggag  tgtgtctta  aatccggac  gctttattg  ccgataaca  tagaacacg  4080
tttattagt  ttgttgcta  actaggctg  gggctttca  tgttctcag  ctggggaaa  4140
ggccattct  gagggttca  tcttcatct  ttggaatca  cgttaaagt  cttgaactg  4200
gaggcgagg  tataccatc  aaacaaaca  gtgaggctg  tttctctca  tccagcagt  4260
ggaagtgct  tttgtggcg  ctgggtagg  catgaaagg  ggcacattg  gatcattct  4320
ggggttttc  gtcagagac  tggggaggt  gtacattta  gcctgttta  taagccacc  4380
gggttctgg  ctgtgtggg  aggaagccc  tggaagcag  gttctttct  ctgacctgc  4440
ctttgagcc  ttatctgtc  ttgtctttc  gtgaaaaca  cacacagaa  ttttttcct  4500
tgggttttg  tttggcgtc  gatgttcca  gacgtcgct  agtgtagtg  tggtctgcg  4560
cagtgtagt  tcagtgcat  ctgcactct  gcttggagg  acagaaaag  caggttaac  4620
tcacgcaga  ggcaagcag  aaagttggg  taggggtgg  gcctcattg  aatagccat  4680
acagtcact  gattcacgg  ttggattcc  ttctgggtt  taaattagg  taccagaat  4740
gagacgttt  agaccccat  ctctcaagg  gttgcgagc  ctcattctc  cagcaaagg  4800
ctccaggat  attcctcag  gggtgggcg  aggtcctga  atggagtac  atagccccg  4860
tcggctcac  ccatgttcc  gcttctgtg  gagtggctg  ggcaaatgt  gggtggctt  4920
gcccagcct  gaccttgtg  ccagcgctc  atccaaagc  aagctctgc  aggctctaa  4980
taggcttcc  acaaggcga  catgagagt  agcacaagg  ccctggatc  tgctataaa  5040
tcatcgtat  tccgaggca  gagaaacac  cacacactc  ccaggcccc  cttgtgtgg  5100
ctttctcaa  cagggattt  ccttttccc  cacagctag  accagccat  gctgtgtct  5160
gctgcccca  agggccctg  ccgggagag  ctttccctg  ataggccga  atagttcct  5220
taaccacag  aggaacctg  ggagaagct  agctacagg  gcactcttg  gtcctccag  5280
gaaatgaga  gggggccaa  cagtctaaa  gcacgtagt  aaggtaact  agtcctaag  5340
acgctgtgg  ccttccacc  ggcaggtcc  tccccactg  gtgaggagc  aagaccact  5400
cccacaggt  ctggggatg  gcttcttct  ctgtttgct  ttttatccc  tgactgttt  5460
gttcacaag  ctccagaca  aacagacgt  ggcggctgc  gatggcctt  gggagtttt  5520
tttttcatc  gattttgcc  cagctcgcc  gaggaatgt  ctgtgttcg  tcagcggcg  5580
ccagcgcag  gtcttgttt  gctctctag  cttggcaag  gcagcctgg  gatgggtaa  5640
agtgctgtg  agtccgggg  ctggtgaag  tcaggacta  gcaggctcc  cctcttctt  5700
ctcctcctc  gtggccagg  ttctcacgt  ccttaccaa  ctcaggtga  aatcttgca  5760
ggagccatc  tccctttcc  ctcacttct  tctgctgtt  cctctgaga  accacgtgt  5820
catgtccgt  cccacctcc  gggtcagca  cagttgagc  cttgttctg  gataaatgc  5880
atgaactat  tgagtgaaa  ggtgccttt  gttacatag  tcttggcta  tgctttttt  5940
tttttcttt  ttctgacca  gctacccca  acctcacag  gttcatgct  ctgccttca  6000
aggatcata  ctaggctgc  ggcctgtgg  tgtcaggct  tgctgaggt  aaattgaca  6060
ccctgtcgg  ggctgactg  aatgctgta  cataaatgc  tgttggcct  acatggcct  6120
acctcagaa  aggagcctg  tccaggatt  ctaacccca  tgtcctttc  cggctctgg  6180
caggcacgg  tctgtttgg  ttgggtttt  atcgatgac  gacattcct  cctttgcag  6240
ctcctcctg  ccaggtgac  gaggctgtg  aggttgcta  cgacatggg  tatcgccac  6300
ttgactgcg  ccaggtgta  cagaatgag  aggaggtgg  ggtggccct  caggagaag  6360
tcaaggagc  ggtggtgaa  cgccaggat  tcttcattg  cagcaaggt  ccaccaatc  6420
gtgaggatg  tggggtcca  ttcactccc  gccaggggg  cccagctgc  agtcaggtc  6480
acccttaac  tgatggcgg  tagtgctgg  cgggtggtg  acctgttac  tgtccacct  6540
tgtatctct  tgctgggcc  gtagatgag  gcctggttg  gggttgact  gcccttgta  6600
ggagtgact  cagggacag  gttaagtta  ttgacaaac  gggtttcac  gctggcctt  6660
agttttagc  agaggctgt  gatgtacaa  ggagcccag  ttggagggc  atgctggct  6720
catgtggac  agcttggct  ggaagtaga  ctagagcat  tgtttagca  ctcctgatc  6780
acagccgtg  ctcgtttag  ctctgtgag  tgctcttga  ctgaccacc  cacttgcct  6840
tgggaagtt  ggatccgca  tatgaactg  aaactctcc  gctactcct  gcgtcatgg  6900
tatggggag  ggagagcat  tgtgtcctc  gccttggga  tgtgtggct  ccagccggg  6960
agaggcatt  gcatggcag  gtaacctgt  ccgtttgct  gctccagct  tggtgcacg  7020
tccacgacc  gagcatggt  aaaggggcc  gccagaaga  gctgagcga  ctgcagctg  7080
actacctgg  cctctacct  attcactgg  caactggct  caaggtgag  ggcacacgg  7140
ggctggatc  gagcggttc  ggtgcggtc  tctctttct  ctcagcacc  tataggtgc  7200
tgactcatc  tgtctctgc  gcttggggt  tgcttctgg  ccagcatca  cgtcatcac  7260
taaaacgta  tagaaacca  cttcaggcc  ctctgcact  tctgaagcg  tggtggctc  7320
gatgcagcc  ttggagtct  ggggacacc  ctcttttca  tcagtgcct  cagaactta  7380
aactgacag  aaatatggc  gacaggact  ctgttgtcc  tgttgcaca  ggctgtagg  7440
gaagcctgc  ccgctgagt  tcctctggg  cttacatgt  atgcacgcc  gcgcgcgcg  7500
gcgcacgca  acacacaca  acacacaca  acacacaca  acacacaca  atgagtctg  7560
acctccgtt  catgccagt  tcatttgtg  ggtgacccg  agatctcag  gtcacttct  7620
gtatttctg  gtggtgacc  agatggaaa  gtcactggt  ttatcctcc  ctctgtttt  7680
gcttaccat  gtctcttgg  gcccgaggg  ctagatttt  accctgtgt  ttttatgac  7740
agccagaaa  agagaggca  agtgatagc  ttctaggtc  gagagccac  gagactcac  7800
gtgcctgag  ttccctacc  tgcccacag  cccttctcc  tgtcaggct  gggctcaga  7860
acttggata  gtctgaatc  ccatttgac  ccctcacag  tccagtcat  acagggatt  7920
ccatcgggg  cactttctg  ttccttttc  tcttggcta  cagatatac  tcttaccat  7980
ttccacagt  tgtagtgct  tgagattaa  aagtctgtg  agaagtgtc  ctgatgatt  8040
tgtgtgtgt  cttgttgtt  ctgacagcc  gggcctgac  atttccccc  ggatgcatc  8100
ggaaacgtg  ttcctagtg  caccgattt  gtggacact  ggacggtaa  atgcccctg  8160
ctgagaccc  tgtttattg  tggtaccct  ttattgtgt  caagccagg  gtgagtgat  8220
tgctctgcc  tgtcctgtg  ttagatcat  ccgtctctg  gtctgtctg  taagtctcg  8280
gaaagccag  ccagttttc  tcttggctt  tgaaagata  aagggtctg  ccgcggatg  8340
gagggctca  ctgtaaagt  ctggacaca  acatgcttc  ggttcttgt  ctcttggag  8400
tcattttag  actcagatc  cttttcttt  taggctatg  agcaactag  ggatgaagg  8460
ttggtaaaa  caatcggag  ctccaactt  aaccctctt  agattgaga  gatcttgaa  8520
aaacctggc  taaagtata  gcctgctgt  aaccaggta  gcgtcccca  gggaggatg  8580
tggcatgct  ttttaccag  cctggctct  gcctgtgga  cacagagag  agaagctct  8640
cagggatag  atttgaggc  agtcagcaa  gacgtggct  ctaacataa  ccgtgggta  8700
ctggtgaga  ctgcaggct  ttatctatt  ataatggcc  aggccaggg  aggccttat  8760
ggcttatgg  catagagca  tggcaacaa  attattctt  ctcttaatg  gaaggccat  8820
agctgggaa  tgtggagag  tgttccagc  tatctggga  gcagacatt  ctgtgtggg  8880
agaaaaggg  cattgacca  gtcacatga  tttgtgtcc  ctgccacag  cacccctcc  8940
gcttgtgtt  cagatcgag  gccacccat  cctaactca  gagaagctg  ttgagtact  9000
ccattgcaa  ggcatcgtg  tgactgcat  cagtcccct  ggttctcct  acaggccct  9060
gtgagcttc  gtgggagca  tgttggaga  aagaaataa  caaagggaa  gattggttg  9120
cagagagaa  gcttctgtg  tggctgcag  ccttccgtg  gtcctctgg  cttcctggg  9180
ggttcatgt  tctaggagc  agagatgga  atatattct  ttgcaaagg  tcagcaggt  9240
gatcatgac  cagcttcgg  ctaggagcc  gaccaacca  ccaggagtc  gtgggagga  9300
cagggctag  tggccggct  ccttgagtg  cagtggtga  gattgttga  ttccccatc  9360
ctctgctcc  gggccaagc  tgaggaccc  tctctcctg  aggatccca  gatcaagga  9420
attgcagcc  agtacaata  aactacagc  caggtatgg  tgcttcttg  tacttttga  9480
tgaactcta  actcacagt  gtccctgtc  gtcaggagt  gagggggct  agcctgaag  9540
cctctgtgg  agtgtggtt  ggagtccta  aatgcagtt  aggggcaca  atgtagaaa  9600
tgagagaat  aagtgacac  tggccctgg  acaatagtg  ctgtcccca  cgtctctat  9660
tgcggcaca  gcatcagcc  agcgtttag  gctgttctt  gaagctctt  ccggttact  9720
atagaagag  tcttactgc  tgcggtgtg  gaggtgttc  ctttcttcc  ggggtagtg  9780
gaccaggca  tgacttcct  tggccttgt  acatgcctg  agccactga  ggagcagga  9840
tgtagggtc  gatttgcac  aactcgtgg  tgtcacttg  cgtctcaca  cctctttgc  9900
tgtgcactt  ttgactgag  tggtaacac  gtgtattta  acactccac  cctctgcat  9960
cgcaggtgc  gatccggtt  cccatccaa  ggaacctgg  cgtgatccc  aagtctgtg  10020
caccagcac  tattgctga  aactttaag  taagatccc  gctccaggc  tggctttcc  10080
ccatggcag  tgggtcctg  gggttctcg  cctcccctt  ctttcccag  tgtgtgatt  10140
cgagcaagt  acttgacta  actcaaaac  gtgcctatg  tgagggctg  ggtgagact  10200
aagttcgtg  tgcacacgc  acagcactt  atagccctg  ttccacact  agtgctcag  10260
aaacattgc  gtgctggtg  tgggtccat  gacgcccag  acatacacc  atccactgg  10320
tctgttaag  cctaagcag  catgagcag  ggtgggaat  cttgggcac  aggagtgta  10380
gcatggaga  tgccctacc  ccaccactg  agcagctca  gctacctgg  gagaggcta  10440
ctgggaaag  gctgctcca  gacggtcct  ggaccacat  acaggagcc  ctggcccgt  10500
aaagcaaag  gatgctctg  cgaagtctg  ttcaaagtc  gccccacag  gtccacaat  10560
ggcactaga  tggttctga  gacatagta  gctactcta  tcctacctc  tcctcgtga  10620
cgtgaccat  cataccact  acatgtaac  atgtgggac  agagacatg  cctgctaga  10680
atgggttaa  acctcaccc  ataattcat  tctaaagta  tagggaaga  aacacagcc  10740
ggcggtggt  gcgcacacc  ttaatccca  cacttggga  tcagaggca  gtggatctg  10800
gagtttgag  ccagcctgg  ttgcagagc  agttccagg  cagccaggg  tacacagag  10860
aactgtctt  aaaaagaag  aagaatgtc  gtgaccaat  ttaacccac  gacctagtg  10920
ttcgttttt  tttgtttct  tttttcatc  tactgtgca  tttgcttgt  tctccatgg  10980
tgcagtcac  agagaatgt  gcagagtct  gtcctgcac  ttccgccat  agaatgtgc  11040
aagtggagt  ggttgtcag  gtgcagctc  atttccaag  cctggtgct  cggaaggcc  11100
tctggtcta  ttgtccacc  tgtacccta  cttcttttc  gtattctgt  gtggggtat  11160
caccggaga  gactaagca  acatgagtt  aaacaagta  aaagtcttt  ttagccagc  11220
tgtgactac  ctgggtgtt  gggatccca  gcctttctc  gggtttaag  acacaatca  11280
atcttgggt  tgatacacc  cagttaaca  gaacaatta  ccagaggta  aactgcaga  11340
gccagaagg  gaggctagc  catgtagag  cttttccag  actatggac  ttgatgtga  11400
ttaaaaata  aaacaaaca  aaaaattag  aaggaaagg  catgactgc  cctgaaccg  11460
ggggttggg  tgaggggga  caagtacaa  agccaggaa  ccaaaggta  aaaaggagc  11520
aagtgggta  taagggaac  gtcgggctg  ataggggag  ggctggaga  ctgagtaga  11580
ggtgggtgt  cccgccaca  cctgtaatt  gtagggact  aagggtatt  aacctggag  11640
ccaggtctg  ttagctacc  taaataggc  ccttagacg  ttgccctgg  attgaaatt  11700
aacagcagg  tagccccag  tctggcaca  aacacccca  gactgtaat  catccttca  11760
cttcacctt  gctgggtgt  ttgcttggt  tttgatttg  ctgacggtg  tgtgtacct  11820
ctgagtttt  tgacttgaa  ggtacttcc  tccatcatg  agtcagtgt  ctagggtct  11880
ttacatatt  ctgtattca  tcttttgtc  tcgtggaag  ctttcttgc  ctgtatgtc  11940
aaacctgac  tattttctt  ggccttgtc  cacatggat  cgcgaggca  tgtccttcg  12000
tccccagct  gagtgcctt  ctggggaca  cccagagcc  ttctttcat  acagcgcag  12060
acccagaac  cggattaat  ggtgttcca  ctattgagg  gtctcctct  acacttctg  12120
tgaatggag  agtcaggac  ctcagtaac  tttcccctg  tgcttatca  agtagagcg  12180
ctcaggagc  tgacaggaa  gactgaaca  tgccctctg  ttggaaatc  tggaaggga  12240
aggccattt  agatagggc  acaagcctg  accttctgg  gcataatta  cagtcttct  12300
gaagtccca  gtcctctcc  gccctctgc  ctccaggca  tgagggcca  ctggaactt  12360
ctgctttgt  tctgtttta  tgtgagctt  ttgactttg  ttctttcct  catgtttgt  12420
tgtaaggtc  ttgactttg  gctgagcaa  gaggacatg  ccactctac  cagctacaa  12480
aggaactgg  gggtgtgcg  cttgatgag  tgagttcca  tgtggtgcc  gttctacct  12540
ttctatgtc  ccaaatgtt  agactaaca  gcatctctc  ggccccaga  gcagggtcc  12600
tcccctgca  cccgccctg  tttcacaca  accttgtct  ctaatctat  cagacccgg  12660
ggcactgca  aaagccagg  gagggtggc  gtcaggaga  ctgcctggg  gcacagttg  12720
tccactttg  cttttctga  ctcagatgg  cccaggggc  tctctggta  ccaccttcc  12780
agaagagtt  gcatgtgac  gattgactt  atgacgcta  cgaggagtt  ggtaggaag  12840
ccctggtgc  gggctcagg  tagccccag  tctggcaca  aacaccctg  gactgtaat  12900
ccactcaga  ggctgtaat  ccactcaga  ggctgtaat  ccactcaga  ggcttaatg  12960
cactcgggc  cccagggcc  ttcagcttc  cctctgctg  ttttttgct  ccctctgaa  13020
tggggtttg  actccgaat  cctggggat  agtttgctt  aagaagcag  ctgtgtccc  13080
aatgcctgc  ttgtcttcc  gtcttgatt  tcactcaca  tctcttgct  tcactcgcc  13140
tctgcataa  tcggtgttt  cctggtggt  gccgcaacc  ctacggtct  tataggcag  13200
aaggtttgt  attcgggct  tttacatgt  gccatcaca  agtcctcag  ttctaagta  13260
gctgtaaac  gaactagcc  aggactctg  aacaggacc  tttctgata  tacactaag  13320
acgtttaac  ttttaatgt  aaaatcatc  tttactttg  atctaacgg  caggagaga  13380
gcgaatcac  tgcctgtag  atccatccg  ttcctagag  ctgtagtag  taagtcact  13440
agccctgcg  gttccctgg  actgctgat  ctgacatca  agcttgtgg  gagagcaaa  13500
cctttgtgt  tgctcacct  cttgcacct  ccatgacta  tctagaagc  gctgtgctt  13560
gacagtact  agttgacat  ggttgcagt  ggggttggg  caggggcgg  ctctagtgc  13620
cccagcaaa  ctttcctaa  atgccagcc  tcctgtgga  acacacggc  atactgagc  13680
cttgctgct  gtgtctgag  ccaggatgc  aagaaaggc  gttgcgggg  agcttgagt  13740
atctgagtg  tcagtgaga  ctgcatacc  ggggcctgg  tcatcctca  cctctgggg  13800
gtggaaaga  acgagcagt  cacttttgc  tggattcta  aagagaagc  caacctcag  13860
cgaaaacat  ctcatcttc  gaggagtag  gcaaccttt  ttagtttga  ttgattaag  13920
aagaaatga  ctttcttat  tttgattta  cttcctgct  ttctccaaa  agcaggagc  13980
gtctgggac  tcatggtat  gtctctgat  ttttattgc  gaattaact  gattttttt  14040
taatgtgag  gtgtgtgtg  cacactagt  gtcctttga  tccaacatg  gcgcgcacg  14100
gcacacaca  acacacaca  acacacaca  acacacaca  acacacaca  acacacaca  14160
acacacacg  gttcaggct  tgacactgt  cctgcctag  ttctctagt  ttcttgcca  14220
tttgttccc  ttataagcc  ttggcccta  caaatagac  gtgaacctt  gctccatgc  14280
agcccttgc  ctgttcctg  agtacatcc  cagctgctg  taggtgctc  tttcactcc  14340
gatgtcaca  aggggcctc  cctttcctg  gagtggctg  ctgtttgac  tgcccttca  14400
ggttcagtg  ggtacagct  gtaaaccct  ctactgctt  gttatctct  ttcttttgg  14460
cctgtgttc  ggagctgat  aaatgaact  ggtgtagtg  cacacgcct  taatcccag  14520
acttgggag  tggagtcag  aagacctga  cttcaaggt  atcctcagc  aagcagtgt  14580
tttgaggcc  gccccgcct  accagaccc  gtcttaaaa  acagcagaa  gttgacatg  14640
ggctgtatg  tcctgccag  tcctcagag  tcccacgca  gacttgctg  ccagtgtgc  14700
ccaggctag  gcttagtgc  gcctgtcac  tgatgcagt  cctgacatc  caagacaag  14760
ggagctcag  gcctgagta  ctgtaccta  gatcagaag  ctctaagac  gctcagtcc  14820
cagtgagac  ccgtttctc  gtgttggtg  ctcgttcgt  acagacaga  tctttttcc  14880
tgagagctg  caaggtggt  cagagtgtt  agacatttg  atcaatcct  aggataaac  14940
gagtttatc  aggacccac  cgataggag  gaagcaact  acactaaat  aataagtga  15000
cccaattaa  tttaggaag  ctttaactt  taaattgca  gtattcttt  ctgacagct  15060
tgccaaaca  aaggattac  ccttccacg  agaagtctg  agctgtggt  gacgaatcc  15120
gctcctccc  aagcgactt  acacatgtt  tttctgcct  atctgccct  gcaagtgtc  15180
ctctgcact  ggtggcacc  tgcagacca  atggtgaga  tttgttagt  tgacgtaga  15240
tgtggaggg  agtaccagt  gctgaggag  ttcttcggc  tttcttggt  ttcttccca  15300
ctggaggac  ttaacacga  taccttttc  aaccaaaga  aaagcaaga  ttatagccc  15360
agtcatgcc  ctaacactt  aatttgagt  cttagaact  cagtcctat  ggggtcaga  15420
tttttgcct  aaataaaaa  tgcttttgt  aatttggtg  tcgtctgtt  tgcttttgc  15480
ctgtaatac  gtgcacccc  tctgcccca  acccagcct  agtgccaag  acaggccag  15540
gctgtgaac  aactgagaa  tcgtatcct  gcacgacac  gcagagtgt  agggtggtg  15600
gtagcatcc  ggtgacatg  tgagctc  15627



<210> 3733
<211> 315
<212> PRT
<213> Rattus norvegicus
<308> AAA40721
<400> 3733

Ala Ser His Leu Glu Leu Asn Asn Gly Thr Lys Met Pro Thr Leu Gly 
  1               5                  10                  15
Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val Lys 
             20                  25                  30
Val Ala Ile Asp Met Gly Tyr Arg His Ile Asp Cys Ala Gln Val Tyr 
         35                  40                  45
Gln Asn Glu Lys Glu Val Gly Val Ala Leu Gln Glu Lys Leu Lys Glu 
     50                  55                  60
Gln Val Val Lys Arg Gln Asp Leu Phe Ile Val Ser Lys Leu Trp Cys 
 65                  70                  75                  80
Thr Phe His Asp Gln Ser Met Val Lys Gly Ala Cys Gln Lys Thr Leu 
                 85                  90                  95
Ser Asp Leu Gln Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro 
             100                105                110
Thr Gly Phe Lys Pro Gly Pro Asp Tyr Phe Pro Leu Asp Ala Ser Gly 
         115                120                125
Asn Val Ile Pro Ser Asp Thr Asp Phe Val Asp Thr Trp Thr Ala Met 
     130                135                140
Glu Gln Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Val Ser Asn 
 145                150                155                160
Phe Asn Pro Leu Gln Ile Glu Arg Ile Leu Asn Lys Pro Gly Leu Lys 
                 165                170                175
Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr Gln 
             180                185                190
Glu Lys Leu Ile Glu Tyr Cys His Cys Lys Gly Ile Val Val Thr Ala 
         195                200                205
Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu Asp 
     210                215                220
Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Glu Ile Ala Ala Lys Tyr 
 225                230                235                240
Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Ile Gln Arg Asn 
                 245                250                255
Leu Val Val Ile Pro Lys Ser Val Thr Pro Ala Arg Ile Ala Glu Asn 
             260                265                270
Phe Lys Val Phe Asp Phe Glu Leu Ser Asn Glu Asp Met Ala Thr Leu 
         275                280                285
Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Met Ser Cys Ala 
     290                295                300
Lys His Lys Asp Tyr Pro Phe His Ala Glu Val 
 305                310                315



<210> 3734
<211> 1367
<212> DNA
<213> Homo sapiens
<308> NM_001628
<400> 3734

gaaggccgc  ccgtactgg  cgggggtct  gggagcgca  cagccatgg  aagccgtct  60
ctgctcaac  acggcgcca  gatgcccat  ctggggttg  gtacctgga  gtcccctcc  120
gggcaggtg  ctgaggccg  gaaggtggc  attgacgtc  ggtaccgcc  catcgactg  180
gcccatgtg  accagaatg  gaatgaggt  ggggtggcc  ttcaggaga  gctcaggga  240
caggtggtg  agcgtgagg  gctcttcat  gtcagcaag  tgtggtgca  gtaccatga  300
aagggcctg  tgaaaggag  ctgccagaa  acactcagc  acctgaagc  ggactacct  360
gacctctac  ttattcact  gccgactgg  tttaagcct  ggaaggaat  tttcccatt  420
gatgagtcg  gcaatgtgg  tcccagtga  accaacatt  tggacacgt  ggcggccat  480
gaagagctg  tggatgaag  gctggtgaa  gctattggc  tctccaact  caaccatct  540
caggtggag  tgatcttaa  caaacctgg  ttgaagtat  agcctgcag  taaccagat  600
gagtgccac  catatctca  tcaggagaa  ttaatccag  actgccagt  caaaggcat  660
gtggtgacc  cctacagcc  cctcggctc  cctgacagg  cctgggcca  gcccgagga  720
ccttctctc  tggaggatc  caggatcaa  gcgatcgca  ccaagcaca  taaaactac  780
gcccaggtc  tgatccggt  ccccatgca  aggaacttg  tggtgatcc  caagtctgt  840
acaccagaa  gcattgctg  gaactttaa  gtctttgac  ttgaactga  cagccagga  900
atgaccacc  tactcagct  caacaggaa  tggagggtc  gtgccttgt  gagctgtac  960
tcccacaag  attacccct  ccatgaaga  ttttgaagc  gtggttgcc  gctcgtccc  1020
aagtgacct  tacctgtgt  tcttgcctc  tttttttcc  tgcaaatgt  gtatggcct  1080
tgtcactca  cagtgggac  gcaacctgt  gagtggcca  cgagggcgt  tctagcttg  1140
tgttggatc  caagagccc  gtcagtaga  tagaagtct  ttccagttt  ctttgccct  1200
ctttctacc  tgctgggga  agtacaacc  gaataccct  ttctgacca  agagaagca  1260
aatctacca  gtcaaaata  tgccactaa  ggttgagtt  tgactgctt  gaactggaa  1320
cctttcagc  agacttctc  ttgcctcaa  taaaaagtg  ttttgtg  1367



<210> 3735
<211> 315
<212> PRT
<213> Homo sapiens
<308> P15121
<400> 3735

Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu Gly 
  1               5                  10                  15
Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val Lys 
             20                  25                  30
Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val Tyr 
         35                  40                  45
Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg Glu 
     50                  55                  60
Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Leu Trp Cys 
 65                  70                  75                  80
Thr Tyr His Glu Lys Gly Leu Val Lys Gly Ala Cys Gln Lys Thr Leu 
                 85                  90                  95
Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro 
             100                105                110
Thr Gly Phe Lys Pro Gly Lys Glu Phe Phe Pro Leu Asp Glu Ser Gly 
         115                120                125
Asn Val Val Pro Ser Asp Thr Asn Ile Leu Asp Thr Trp Ala Ala Met 
     130                135                140
Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser Asn 
 145                150                155                160
Phe Asn His Leu Gln Val Glu Met Ile Leu Asn Lys Pro Gly Leu Lys 
                 165                170                175
Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr Gln 
             180                185                190
Glu Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Val Val Thr Ala 
         195                200                205
Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu Asp 
     210                215                220
Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Ala Ile Ala Ala Lys His 
 225                230                235                240
Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Met Gln Arg Asn 
                 245                250                255
Leu Val Val Ile Pro Lys Ser Val Thr Pro Glu Arg Ile Ala Glu Asn 
             260                265                270
Phe Lys Val Phe Asp Phe Glu Leu Ser Ser Gln Asp Met Thr Thr Leu 
         275                280                285
Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Leu Ser Cys Thr 
     290                295                300
Ser His Lys Asp Tyr Pro Phe His Glu Glu Phe 
 305                310                315



<210> 3736
<211> 15627
<212> DNA
<213> Rattus norvegicus
<308> M60322
<400> 3736

ggatccagg  agttcaaat  gcagagaag  ctctatgcc  agagggatt  cacagagga  60
aagtggcgg  tgtcaggtc  cctgttatc  tacacaaac  taatcccca  cactacact  120
aaattcaaa  tctactatt  agagaaaaa  tacacaaga  cttccacat  ccaacagct  180
tggggtttt  ttttgttaa  aaaatccaa  tggaaaata  ctgttcttt  taaattttc  240
cagggatgg  agtggaaga  tgccacctt  taggagggc  ccaactgga  aatcaccag  300
atggcactt  gagaggtgg  gttcctgac  cattactct  cagatgcag  tgtctgtgt  360
gcataatca  gggggcgac  gaagcatga  ccagcagaa  gagactcag  caaaacaga  420
catcacgca  aggggtgtt  gaagagtgc  aaatttccg  cattgttct  ggggcaact  480
cgattattt  agggaaagt  tttgttttt  tacccaata  caactgatt  atttatttt  540
tgtcccctt  acttggaat  attgctgta  gaaaacgga  ttttcctag  atgggattc  600
gcctgttca  ttttcttcc  gagagagtt  ggtcaactt  ctatactgg  acctgcccg  660
tcaacagtt  tactttccc  aatcattta  gtgtgatcc  gagatcaag  ttatgaggg  720
ttatagcta  cggttgctg  gtttcgcat  aaggcttgt  gaaccagat  gagcatgtt  780
agacactgg  aatggtaga  agctactac  agcgggcat  ttgtagtat  ttgcaaagc  840
ggttacaat  atttcaatt  agggggctg  gggaggggg  ggcttaaat  cacctgaag  900
ttaactttt  acataagac  aaaaaaaaa  aaaaaaaaa  aaaaaaagc  cttaagtac  960
cctgacgcc  atctgctcc  tcagtttca  aacaagatg  gcaggattc  agaagagta  1020
tattctgag  ttagaaaaa  acacaagcg  ctttttctg  cctctaaaa  gaaaccaaa  1080
ccttttccc  gtctcctta  ctctagtct  ccggttatt  tcagagcgt  tagtctggt  1140
cttcaacag  aggcaaaca  tctgccacg  ggggcgcag  gcagctgga  aattccgtg  1200
ctctaggac  tagggaaag  agcatcctc  ctgaccctt  aaggaccac  gaagagacc  1260
atcagaagg  gccgtctct  agccgtgcg  caatcgcag  cgtcctttc  gcaggctgt  1320
ggggctatt  aaaggtgcg  gccggagcc  gcgctgcac  cttgcgggt  gttgtgcgt  1380
acttgcagc  atcatggct  gccatctgg  actcaacaa  ggcaccaag  tgcccaccc  1440
gggtctggg  acctggaag  taggtgctc  tcagggcgt  gcccgccac  cgctgggtg  1500
ccctgagcg  cctgcgcgg  gcggggctc  ggtggttgg  gcctgtggg  gcatccggc  1560
gcggccccg  gtgtggggc  ctgggcgag  attgcgcga  tccgcgtgg  tgccccagg  1620
ggagacaca  ccacggggg  gagaggaac  gaagcaggg  tctagattt  tcatctggc  1680
ccccaaact  acgagtgag  tgacctcac  tggagcaga  gttgccctc  cgggaatga  1740
ccacttggc  gataggcct  agataatta  attaggagg  gagagtttg  agtgaacca  1800
cctgtttct  ttttcctta  atcgctgag  gcagctctt  acgggtgcg  aactcctct  1860
gaattaatc  ggtttccgc  ttgctgggt  ccaccctcc  caaacccca  cacaacaca  1920
caggcttga  aagacggcc  gatacgtta  agtgaaata  aaaaagaaa  aaccgataa  1980
taaaaacta  aaattataa  tgatttgat  atttgaaaa  taaggaacc  gttttggtg  2040
tattgctga  gcagaaaaa  ccagctctt  agctactgc  gtgacctgg  tctttaaga  2100
cctggagta  gggtgaacc  gggctgtat  taagcactt  gacacagtg  aggaaagag  2160
aaatcatgc  gggttgagt  cagatggtt  gaaactgga  agtctgttt  tacccagac  2220
acagttaaa  tgggtaatg  atatggtga  taagaaaca  gtcatagac  tgtctttct  2280
tgaatgtgt  tctaagcca  tagattagc  agtgcggct  tcgtttcct  ccaaagggt  2340
cttggtgac  gtaaagatg  gattgaatg  gaaccatca  accagatta  attctatgc  2400
ttggaagga  aagaaagat  gtttccttg  tgtaataaa  acagcacag  aaaggcaca  2460
ataactaca  tggttttgt  atacacgac  ctcaacatg  gtgggatgc  gatacttta  2520
ttctgtccc  tttctctaa  aaccaagct  ataacttta  aaaagcatt  tgagatcag  2580
tctcgggta  acacgagta  acattcata  gccggtggc  agagcggat  caacagccc  2640
agagagctg  gtgtttgtt  aaaattaca  acattttaa  gtatagatc  ttctgccgc  2700
ttcacagat  ttcctgtca  ttcccgcag  gcctggctt  tagaatgga  ccagaagtc  2760
tgttgagtt  gggcagggt  aagaaaatg  ctgcctgtg  ctgggggca  ggggaggtt  2820
gtgcagaga  cgtggaggg  cgaagggtg  cagtgagag  caggaggac  gccgagact  2880
ccagatttc  ttttttttt  ttttttttt  tttggttct  tttttttcg  agctgggga  2940
cgaacccag  gccttgcgc  tcctaggca  gcgctctac  actgagcta  atccccagc  3000
cccagattt  cctttttaa  aaaagaata  caacttaat  ctttccttg  acatgtgtg  3060
cgttccttc  tagatgaca  agtatatca  agtcactgt  atggtcaca  agggtgtgt  3120
ggtgcggtc  cttgttctg  aacttcatc  gtggccacc  ggtacctca  agaccacag  3180
gggactctg  cagggtatg  tccactctt  ccttgaggg  atctgtttc  cctgggagg  3240
gaggatttg  ggcagttgg  agacactct  acttgcatg  actttcttc  tggccaact  3300
gcctgccct  tggaccccc  aaatgcatg  taaatatac  atattacat  aaaatactg  3360
tttaagttt  gtgtggtca  gaggccttt  aggcagagc  ggcctgata  agaccacca  3420
gccctttta  tgataatgt  ttgacctag  tgaaaatct  tgaaggaca  ggccattgt  3480
tcttccaca  ataggctag  aattgctgc  aggaatgta  ggacagctg  gttctcaga  3540
tattttcca  ttaatgccc  ctgtgcctc  aaaccatga  tctcttgag  tgaactttt  3600
ttttctttt  ggcctaatt  tatcccaat  ggattctgg  atctcagat  aaactacta  3660
atatgtgct  acgccctgt  ttccctttc  cagggtcac  tggcattct  aagctgtga  3720
atattttct  tgcttgctt  ttgagtgtg  tttttgcct  tctgggata  tagtacttg  3780
ccttagaag  aaactgtgc  agggtcctc  tgccatttc  tgagttaaa  caagtgtcc  3840
ctgacagtc  tagagcctg  ggtcaggga  aaatgctgt  ctcattgaa  taggagttt  3900
gttttctgg  ggcctgcca  tgaccaggc  acactcctc  acctttcca  atttaagat  3960
aaaaaaaaa  atcaaatat  tcttgtcta  gcagggccg  tcctggagc  acatctctg  4020
ggagtggag  tgtgtctta  aatccggac  gctttattg  ccgataaca  tagaacacg  4080
tttattagt  ttgttgcta  actaggctg  gggctttca  tgttctcag  ctggggaaa  4140
ggccattct  gagggttca  tcttcatct  ttggaatca  cgttaaagt  cttgaactg  4200
gaggcgagg  tataccatc  aaacaaaca  gtgaggctg  tttctctca  tccagcagt  4260
ggaagtgct  tttgtggcg  ctgggtagg  catgaaagg  ggcacattg  gatcattct  4320
ggggttttc  gtcagagac  tggggaggt  gtacattta  gcctgttta  taagccacc  4380
gggttctgg  ctgtgtggg  aggaagccc  tggaagcag  gttctttct  ctgacctgc  4440
ctttgagcc  ttatctgtc  ttgtctttc  gtgaaaaca  cacacagaa  ttttttcct  4500
tgggttttg  tttggcgtc  gatgttcca  gacgtcgct  agtgtagtg  tggtctgcg  4560
cagtgtagt  tcagtgcat  ctgcactct  gcttggagg  acagaaaag  caggttaac  4620
tcacgcaga  ggcaagcag  aaagttggg  taggggtgg  gcctcattg  aatagccat  4680
acagtcact  gattcacgg  ttggattcc  ttctgggtt  taaattagg  taccagaat  4740
gagacgttt  agaccccat  ctctcaagg  gttgcgagc  ctcattctc  cagcaaagg  4800
ctccaggat  attcctcag  gggtgggcg  aggtcctga  atggagtac  atagccccg  4860
tcggctcac  ccatgttcc  gcttctgtg  gagtggctg  ggcaaatgt  gggtggctt  4920
gcccagcct  gaccttgtg  ccagcgctc  atccaaagc  aagctctgc  aggctctaa  4980
taggcttcc  acaaggcga  catgagagt  agcacaagg  ccctggatc  tgctataaa  5040
tcatcgtat  tccgaggca  gagaaacac  cacacactc  ccaggcccc  cttgtgtgg  5100
ctttctcaa  cagggattt  ccttttccc  cacagctag  accagccat  gctgtgtct  5160
gctgcccca  agggccctg  ccgggagag  ctttccctg  ataggccga  atagttcct  5220
taaccacag  aggaacctg  ggagaagct  agctacagg  gcactcttg  gtcctccag  5280
gaaatgaga  gggggccaa  cagtctaaa  gcacgtagt  aaggtaact  agtcctaag  5340
acgctgtgg  ccttccacc  ggcaggtcc  tccccactg  gtgaggagc  aagaccact  5400
cccacaggt  ctggggatg  gcttcttct  ctgtttgct  ttttatccc  tgactgttt  5460
gttcacaag  ctccagaca  aacagacgt  ggcggctgc  gatggcctt  gggagtttt  5520
tttttcatc  gattttgcc  cagctcgcc  gaggaatgt  ctgtgttcg  tcagcggcg  5580
ccagcgcag  gtcttgttt  gctctctag  cttggcaag  gcagcctgg  gatgggtaa  5640
agtgctgtg  agtccgggg  ctggtgaag  tcaggacta  gcaggctcc  cctcttctt  5700
ctcctcctc  gtggccagg  ttctcacgt  ccttaccaa  ctcaggtga  aatcttgca  5760
ggagccatc  tccctttcc  ctcacttct  tctgctgtt  cctctgaga  accacgtgt  5820
catgtccgt  cccacctcc  gggtcagca  cagttgagc  cttgttctg  gataaatgc  5880
atgaactat  tgagtgaaa  ggtgccttt  gttacatag  tcttggcta  tgctttttt  5940
tttttcttt  ttctgacca  gctacccca  acctcacag  gttcatgct  ctgccttca  6000
aggatcata  ctaggctgc  ggcctgtgg  tgtcaggct  tgctgaggt  aaattgaca  6060
ccctgtcgg  ggctgactg  aatgctgta  cataaatgc  tgttggcct  acatggcct  6120
acctcagaa  aggagcctg  tccaggatt  ctaacccca  tgtcctttc  cggctctgg  6180
caggcacgg  tctgtttgg  ttgggtttt  atcgatgac  gacattcct  cctttgcag  6240
ctcctcctg  ccaggtgac  gaggctgtg  aggttgcta  cgacatggg  tatcgccac  6300
ttgactgcg  ccaggtgta  cagaatgag  aggaggtgg  ggtggccct  caggagaag  6360
tcaaggagc  ggtggtgaa  cgccaggat  tcttcattg  cagcaaggt  ccaccaatc  6420
gtgaggatg  tggggtcca  ttcactccc  gccaggggg  cccagctgc  agtcaggtc  6480
acccttaac  tgatggcgg  tagtgctgg  cgggtggtg  acctgttac  tgtccacct  6540
tgtatctct  tgctgggcc  gtagatgag  gcctggttg  gggttgact  gcccttgta  6600
ggagtgact  cagggacag  gttaagtta  ttgacaaac  gggtttcac  gctggcctt  6660
agttttagc  agaggctgt  gatgtacaa  ggagcccag  ttggagggc  atgctggct  6720
catgtggac  agcttggct  ggaagtaga  ctagagcat  tgtttagca  ctcctgatc  6780
acagccgtg  ctcgtttag  ctctgtgag  tgctcttga  ctgaccacc  cacttgcct  6840
tgggaagtt  ggatccgca  tatgaactg  aaactctcc  gctactcct  gcgtcatgg  6900
tatggggag  ggagagcat  tgtgtcctc  gccttggga  tgtgtggct  ccagccggg  6960
agaggcatt  gcatggcag  gtaacctgt  ccgtttgct  gctccagct  tggtgcacg  7020
tccacgacc  gagcatggt  aaaggggcc  gccagaaga  gctgagcga  ctgcagctg  7080
actacctgg  cctctacct  attcactgg  caactggct  caaggtgag  ggcacacgg  7140
ggctggatc  gagcggttc  ggtgcggtc  tctctttct  ctcagcacc  tataggtgc  7200
tgactcatc  tgtctctgc  gcttggggt  tgcttctgg  ccagcatca  cgtcatcac  7260
taaaacgta  tagaaacca  cttcaggcc  ctctgcact  tctgaagcg  tggtggctc  7320
gatgcagcc  ttggagtct  ggggacacc  ctcttttca  tcagtgcct  cagaactta  7380
aactgacag  aaatatggc  gacaggact  ctgttgtcc  tgttgcaca  ggctgtagg  7440
gaagcctgc  ccgctgagt  tcctctggg  cttacatgt  atgcacgcc  gcgcgcgcg  7500
gcgcacgca  acacacaca  acacacaca  acacacaca  acacacaca  atgagtctg  7560
acctccgtt  catgccagt  tcatttgtg  ggtgacccg  agatctcag  gtcacttct  7620
gtatttctg  gtggtgacc  agatggaaa  gtcactggt  ttatcctcc  ctctgtttt  7680
gcttaccat  gtctcttgg  gcccgaggg  ctagatttt  accctgtgt  ttttatgac  7740
agccagaaa  agagaggca  agtgatagc  ttctaggtc  gagagccac  gagactcac  7800
gtgcctgag  ttccctacc  tgcccacag  cccttctcc  tgtcaggct  gggctcaga  7860
acttggata  gtctgaatc  ccatttgac  ccctcacag  tccagtcat  acagggatt  7920
ccatcgggg  cactttctg  ttccttttc  tcttggcta  cagatatac  tcttaccat  7980
ttccacagt  tgtagtgct  tgagattaa  aagtctgtg  agaagtgtc  ctgatgatt  8040
tgtgtgtgt  cttgttgtt  ctgacagcc  gggcctgac  atttccccc  ggatgcatc  8100
ggaaacgtg  ttcctagtg  caccgattt  gtggacact  ggacggtaa  atgcccctg  8160
ctgagaccc  tgtttattg  tggtaccct  ttattgtgt  caagccagg  gtgagtgat  8220
tgctctgcc  tgtcctgtg  ttagatcat  ccgtctctg  gtctgtctg  taagtctcg  8280
gaaagccag  ccagttttc  tcttggctt  tgaaagata  aagggtctg  ccgcggatg  8340
gagggctca  ctgtaaagt  ctggacaca  acatgcttc  ggttcttgt  ctcttggag  8400
tcattttag  actcagatc  cttttcttt  taggctatg  agcaactag  ggatgaagg  8460
ttggtaaaa  caatcggag  ctccaactt  aaccctctt  agattgaga  gatcttgaa  8520
aaacctggc  taaagtata  gcctgctgt  aaccaggta  gcgtcccca  gggaggatg  8580
tggcatgct  ttttaccag  cctggctct  gcctgtgga  cacagagag  agaagctct  8640
cagggatag  atttgaggc  agtcagcaa  gacgtggct  ctaacataa  ccgtgggta  8700
ctggtgaga  ctgcaggct  ttatctatt  ataatggcc  aggccaggg  aggccttat  8760
ggcttatgg  catagagca  tggcaacaa  attattctt  ctcttaatg  gaaggccat  8820
agctgggaa  tgtggagag  tgttccagc  tatctggga  gcagacatt  ctgtgtggg  8880
agaaaaggg  cattgacca  gtcacatga  tttgtgtcc  ctgccacag  cacccctcc  8940
gcttgtgtt  cagatcgag  gccacccat  cctaactca  gagaagctg  ttgagtact  9000
ccattgcaa  ggcatcgtg  tgactgcat  cagtcccct  ggttctcct  acaggccct  9060
gtgagcttc  gtgggagca  tgttggaga  aagaaataa  caaagggaa  gattggttg  9120
cagagagaa  gcttctgtg  tggctgcag  ccttccgtg  gtcctctgg  cttcctggg  9180
ggttcatgt  tctaggagc  agagatgga  atatattct  ttgcaaagg  tcagcaggt  9240
gatcatgac  cagcttcgg  ctaggagcc  gaccaacca  ccaggagtc  gtgggagga  9300
cagggctag  tggccggct  ccttgagtg  cagtggtga  gattgttga  ttccccatc  9360
ctctgctcc  gggccaagc  tgaggaccc  tctctcctg  aggatccca  gatcaagga  9420
attgcagcc  agtacaata  aactacagc  caggtatgg  tgcttcttg  tacttttga  9480
tgaactcta  actcacagt  gtccctgtc  gtcaggagt  gagggggct  agcctgaag  9540
cctctgtgg  agtgtggtt  ggagtccta  aatgcagtt  aggggcaca  atgtagaaa  9600
tgagagaat  aagtgacac  tggccctgg  acaatagtg  ctgtcccca  cgtctctat  9660
tgcggcaca  gcatcagcc  agcgtttag  gctgttctt  gaagctctt  ccggttact  9720
atagaagag  tcttactgc  tgcggtgtg  gaggtgttc  ctttcttcc  ggggtagtg  9780
gaccaggca  tgacttcct  tggccttgt  acatgcctg  agccactga  ggagcagga  9840
tgtagggtc  gatttgcac  aactcgtgg  tgtcacttg  cgtctcaca  cctctttgc  9900
tgtgcactt  ttgactgag  tggtaacac  gtgtattta  acactccac  cctctgcat  9960
cgcaggtgc  gatccggtt  cccatccaa  ggaacctgg  cgtgatccc  aagtctgtg  10020
caccagcac  tattgctga  aactttaag  taagatccc  gctccaggc  tggctttcc  10080
ccatggcag  tgggtcctg  gggttctcg  cctcccctt  ctttcccag  tgtgtgatt  10140
cgagcaagt  acttgacta  actcaaaac  gtgcctatg  tgagggctg  ggtgagact  10200
aagttcgtg  tgcacacgc  acagcactt  atagccctg  ttccacact  agtgctcag  10260
aaacattgc  gtgctggtg  tgggtccat  gacgcccag  acatacacc  atccactgg  10320
tctgttaag  cctaagcag  catgagcag  ggtgggaat  cttgggcac  aggagtgta  10380
gcatggaga  tgccctacc  ccaccactg  agcagctca  gctacctgg  gagaggcta  10440
ctgggaaag  gctgctcca  gacggtcct  ggaccacat  acaggagcc  ctggcccgt  10500
aaagcaaag  gatgctctg  cgaagtctg  ttcaaagtc  gccccacag  gtccacaat  10560
ggcactaga  tggttctga  gacatagta  gctactcta  tcctacctc  tcctcgtga  10620
cgtgaccat  cataccact  acatgtaac  atgtgggac  agagacatg  cctgctaga  10680
atgggttaa  acctcaccc  ataattcat  tctaaagta  tagggaaga  aacacagcc  10740
ggcggtggt  gcgcacacc  ttaatccca  cacttggga  tcagaggca  gtggatctg  10800
gagtttgag  ccagcctgg  ttgcagagc  agttccagg  cagccaggg  tacacagag  10860
aactgtctt  aaaaagaag  aagaatgtc  gtgaccaat  ttaacccac  gacctagtg  10920
ttcgttttt  tttgtttct  tttttcatc  tactgtgca  tttgcttgt  tctccatgg  10980
tgcagtcac  agagaatgt  gcagagtct  gtcctgcac  ttccgccat  agaatgtgc  11040
aagtggagt  ggttgtcag  gtgcagctc  atttccaag  cctggtgct  cggaaggcc  11100
tctggtcta  ttgtccacc  tgtacccta  cttcttttc  gtattctgt  gtggggtat  11160
caccggaga  gactaagca  acatgagtt  aaacaagta  aaagtcttt  ttagccagc  11220
tgtgactac  ctgggtgtt  gggatccca  gcctttctc  gggtttaag  acacaatca  11280
atcttgggt  tgatacacc  cagttaaca  gaacaatta  ccagaggta  aactgcaga  11340
gccagaagg  gaggctagc  catgtagag  cttttccag  actatggac  ttgatgtga  11400
ttaaaaata  aaacaaaca  aaaaattag  aaggaaagg  catgactgc  cctgaaccg  11460
ggggttggg  tgaggggga  caagtacaa  agccaggaa  ccaaaggta  aaaaggagc  11520
aagtgggta  taagggaac  gtcgggctg  ataggggag  ggctggaga  ctgagtaga  11580
ggtgggtgt  cccgccaca  cctgtaatt  gtagggact  aagggtatt  aacctggag  11640
ccaggtctg  ttagctacc  taaataggc  ccttagacg  ttgccctgg  attgaaatt  11700
aacagcagg  tagccccag  tctggcaca  aacacccca  gactgtaat  catccttca  11760
cttcacctt  gctgggtgt  ttgcttggt  tttgatttg  ctgacggtg  tgtgtacct  11820
ctgagtttt  tgacttgaa  ggtacttcc  tccatcatg  agtcagtgt  ctagggtct  11880
ttacatatt  ctgtattca  tcttttgtc  tcgtggaag  ctttcttgc  ctgtatgtc  11940
aaacctgac  tattttctt  ggccttgtc  cacatggat  cgcgaggca  tgtccttcg  12000
tccccagct  gagtgcctt  ctggggaca  cccagagcc  ttctttcat  acagcgcag  12060
acccagaac  cggattaat  ggtgttcca  ctattgagg  gtctcctct  acacttctg  12120
tgaatggag  agtcaggac  ctcagtaac  tttcccctg  tgcttatca  agtagagcg  12180
ctcaggagc  tgacaggaa  gactgaaca  tgccctctg  ttggaaatc  tggaaggga  12240
aggccattt  agatagggc  acaagcctg  accttctgg  gcataatta  cagtcttct  12300
gaagtccca  gtcctctcc  gccctctgc  ctccaggca  tgagggcca  ctggaactt  12360
ctgctttgt  tctgtttta  tgtgagctt  ttgactttg  ttctttcct  catgtttgt  12420
tgtaaggtc  ttgactttg  gctgagcaa  gaggacatg  ccactctac  cagctacaa  12480
aggaactgg  gggtgtgcg  cttgatgag  tgagttcca  tgtggtgcc  gttctacct  12540
ttctatgtc  ccaaatgtt  agactaaca  gcatctctc  ggccccaga  gcagggtcc  12600
tcccctgca  cccgccctg  tttcacaca  accttgtct  ctaatctat  cagacccgg  12660
ggcactgca  aaagccagg  gagggtggc  gtcaggaga  ctgcctggg  gcacagttg  12720
tccactttg  cttttctga  ctcagatgg  cccaggggc  tctctggta  ccaccttcc  12780
agaagagtt  gcatgtgac  gattgactt  atgacgcta  cgaggagtt  ggtaggaag  12840
ccctggtgc  gggctcagg  tagccccag  tctggcaca  aacaccctg  gactgtaat  12900
ccactcaga  ggctgtaat  ccactcaga  ggctgtaat  ccactcaga  ggcttaatg  12960
cactcgggc  cccagggcc  ttcagcttc  cctctgctg  ttttttgct  ccctctgaa  13020
tggggtttg  actccgaat  cctggggat  agtttgctt  aagaagcag  ctgtgtccc  13080
aatgcctgc  ttgtcttcc  gtcttgatt  tcactcaca  tctcttgct  tcactcgcc  13140
tctgcataa  tcggtgttt  cctggtggt  gccgcaacc  ctacggtct  tataggcag  13200
aaggtttgt  attcgggct  tttacatgt  gccatcaca  agtcctcag  ttctaagta  13260
gctgtaaac  gaactagcc  aggactctg  aacaggacc  tttctgata  tacactaag  13320
acgtttaac  ttttaatgt  aaaatcatc  tttactttg  atctaacgg  caggagaga  13380
gcgaatcac  tgcctgtag  atccatccg  ttcctagag  ctgtagtag  taagtcact  13440
agccctgcg  gttccctgg  actgctgat  ctgacatca  agcttgtgg  gagagcaaa  13500
cctttgtgt  tgctcacct  cttgcacct  ccatgacta  tctagaagc  gctgtgctt  13560
gacagtact  agttgacat  ggttgcagt  ggggttggg  caggggcgg  ctctagtgc  13620
cccagcaaa  ctttcctaa  atgccagcc  tcctgtgga  acacacggc  atactgagc  13680
cttgctgct  gtgtctgag  ccaggatgc  aagaaaggc  gttgcgggg  agcttgagt  13740
atctgagtg  tcagtgaga  ctgcatacc  ggggcctgg  tcatcctca  cctctgggg  13800
gtggaaaga  acgagcagt  cacttttgc  tggattcta  aagagaagc  caacctcag  13860
cgaaaacat  ctcatcttc  gaggagtag  gcaaccttt  ttagtttga  ttgattaag  13920
aagaaatga  ctttcttat  tttgattta  cttcctgct  ttctccaaa  agcaggagc  13980
gtctgggac  tcatggtat  gtctctgat  ttttattgc  gaattaact  gattttttt  14040
taatgtgag  gtgtgtgtg  cacactagt  gtcctttga  tccaacatg  gcgcgcacg  14100
gcacacaca  acacacaca  acacacaca  acacacaca  acacacaca  acacacaca  14160
acacacacg  gttcaggct  tgacactgt  cctgcctag  ttctctagt  ttcttgcca  14220
tttgttccc  ttataagcc  ttggcccta  caaatagac  gtgaacctt  gctccatgc  14280
agcccttgc  ctgttcctg  agtacatcc  cagctgctg  taggtgctc  tttcactcc  14340
gatgtcaca  aggggcctc  cctttcctg  gagtggctg  ctgtttgac  tgcccttca  14400
ggttcagtg  ggtacagct  gtaaaccct  ctactgctt  gttatctct  ttcttttgg  14460
cctgtgttc  ggagctgat  aaatgaact  ggtgtagtg  cacacgcct  taatcccag  14520
acttgggag  tggagtcag  aagacctga  cttcaaggt  atcctcagc  aagcagtgt  14580
tttgaggcc  gccccgcct  accagaccc  gtcttaaaa  acagcagaa  gttgacatg  14640
ggctgtatg  tcctgccag  tcctcagag  tcccacgca  gacttgctg  ccagtgtgc  14700
ccaggctag  gcttagtgc  gcctgtcac  tgatgcagt  cctgacatc  caagacaag  14760
ggagctcag  gcctgagta  ctgtaccta  gatcagaag  ctctaagac  gctcagtcc  14820
cagtgagac  ccgtttctc  gtgttggtg  ctcgttcgt  acagacaga  tctttttcc  14880
tgagagctg  caaggtggt  cagagtgtt  agacatttg  atcaatcct  aggataaac  14940
gagtttatc  aggacccac  cgataggag  gaagcaact  acactaaat  aataagtga  15000
cccaattaa  tttaggaag  ctttaactt  taaattgca  gtattcttt  ctgacagct  15060
tgccaaaca  aaggattac  ccttccacg  agaagtctg  agctgtggt  gacgaatcc  15120
gctcctccc  aagcgactt  acacatgtt  tttctgcct  atctgccct  gcaagtgtc  15180
ctctgcact  ggtggcacc  tgcagacca  atggtgaga  tttgttagt  tgacgtaga  15240
tgtggaggg  agtaccagt  gctgaggag  ttcttcggc  tttcttggt  ttcttccca  15300
ctggaggac  ttaacacga  taccttttc  aaccaaaga  aaagcaaga  ttatagccc  15360
agtcatgcc  ctaacactt  aatttgagt  cttagaact  cagtcctat  ggggtcaga  15420
tttttgcct  aaataaaaa  tgcttttgt  aatttggtg  tcgtctgtt  tgcttttgc  15480
ctgtaatac  gtgcacccc  tctgcccca  acccagcct  agtgccaag  acaggccag  15540
gctgtgaac  aactgagaa  tcgtatcct  gcacgacac  gcagagtgt  agggtggtg  15600
gtagcatcc  ggtgacatg  tgagctc  15627



<210> 3737
<211> 315
<212> PRT
<213> Rattus norvegicus
<308> AAA40721
<400> 3737

Ala Ser His Leu Glu Leu Asn Asn Gly Thr Lys Met Pro Thr Leu Gly 
  1               5                  10                  15
Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val Lys 
             20                  25                  30
Val Ala Ile Asp Met Gly Tyr Arg His Ile Asp Cys Ala Gln Val Tyr 
         35                  40                  45
Gln Asn Glu Lys Glu Val Gly Val Ala Leu Gln Glu Lys Leu Lys Glu 
     50                  55                  60
Gln Val Val Lys Arg Gln Asp Leu Phe Ile Val Ser Lys Leu Trp Cys 
 65                  70                  75                  80
Thr Phe His Asp Gln Ser Met Val Lys Gly Ala Cys Gln Lys Thr Leu 
                 85                  90                  95
Ser Asp Leu Gln Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro 
             100                105                110
Thr Gly Phe Lys Pro Gly Pro Asp Tyr Phe Pro Leu Asp Ala Ser Gly 
         115                120                125
Asn Val Ile Pro Ser Asp Thr Asp Phe Val Asp Thr Trp Thr Ala Met 
     130                135                140
Glu Gln Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Val Ser Asn 
 145                150                155                160
Phe Asn Pro Leu Gln Ile Glu Arg Ile Leu Asn Lys Pro Gly Leu Lys 
                 165                170                175
Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr Gln 
             180                185                190
Glu Lys Leu Ile Glu Tyr Cys His Cys Lys Gly Ile Val Val Thr Ala 
         195                200                205
Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu Asp 
     210                215                220
Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Glu Ile Ala Ala Lys Tyr 
 225                230                235                240
Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Ile Gln Arg Asn 
                 245                250                255
Leu Val Val Ile Pro Lys Ser Val Thr Pro Ala Arg Ile Ala Glu Asn 
             260                265                270
Phe Lys Val Phe Asp Phe Glu Leu Ser Asn Glu Asp Met Ala Thr Leu 
         275                280                285
Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Met Ser Cys Ala 
     290                295                300
Lys His Lys Asp Tyr Pro Phe His Ala Glu Val 
 305                310                315



<210> 3738
<211> 1367
<212> DNA
<213> Homo sapiens
<308> NM_001628
<400> 3738

gaaggccgc  ccgtactgg  cgggggtct  gggagcgca  cagccatgg  aagccgtct  60
ctgctcaac  acggcgcca  gatgcccat  ctggggttg  gtacctgga  gtcccctcc  120
gggcaggtg  ctgaggccg  gaaggtggc  attgacgtc  ggtaccgcc  catcgactg  180
gcccatgtg  accagaatg  gaatgaggt  ggggtggcc  ttcaggaga  gctcaggga  240
caggtggtg  agcgtgagg  gctcttcat  gtcagcaag  tgtggtgca  gtaccatga  300
aagggcctg  tgaaaggag  ctgccagaa  acactcagc  acctgaagc  ggactacct  360
gacctctac  ttattcact  gccgactgg  tttaagcct  ggaaggaat  tttcccatt  420
gatgagtcg  gcaatgtgg  tcccagtga  accaacatt  tggacacgt  ggcggccat  480
gaagagctg  tggatgaag  gctggtgaa  gctattggc  tctccaact  caaccatct  540
caggtggag  tgatcttaa  caaacctgg  ttgaagtat  agcctgcag  taaccagat  600
gagtgccac  catatctca  tcaggagaa  ttaatccag  actgccagt  caaaggcat  660
gtggtgacc  cctacagcc  cctcggctc  cctgacagg  cctgggcca  gcccgagga  720
ccttctctc  tggaggatc  caggatcaa  gcgatcgca  ccaagcaca  taaaactac  780
gcccaggtc  tgatccggt  ccccatgca  aggaacttg  tggtgatcc  caagtctgt  840
acaccagaa  gcattgctg  gaactttaa  gtctttgac  ttgaactga  cagccagga  900
atgaccacc  tactcagct  caacaggaa  tggagggtc  gtgccttgt  gagctgtac  960
tcccacaag  attacccct  ccatgaaga  ttttgaagc  gtggttgcc  gctcgtccc  1020
aagtgacct  tacctgtgt  tcttgcctc  tttttttcc  tgcaaatgt  gtatggcct  1080
tgtcactca  cagtgggac  gcaacctgt  gagtggcca  cgagggcgt  tctagcttg  1140
tgttggatc  caagagccc  gtcagtaga  tagaagtct  ttccagttt  ctttgccct  1200
ctttctacc  tgctgggga  agtacaacc  gaataccct  ttctgacca  agagaagca  1260
aatctacca  gtcaaaata  tgccactaa  ggttgagtt  tgactgctt  gaactggaa  1320
cctttcagc  agacttctc  ttgcctcaa  taaaaagtg  ttttgtg  1367



<210> 3739
<211> 315
<212> PRT
<213> Homo sapiens
<308> P15121
<400> 3739

Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu Gly 
  1               5                  10                  15
Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val Lys 
             20                  25                  30
Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val Tyr 
         35                  40                  45
Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg Glu 
     50                  55                  60
Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Leu Trp Cys 
 65                  70                  75                  80
Thr Tyr His Glu Lys Gly Leu Val Lys Gly Ala Cys Gln Lys Thr Leu 
                 85                  90                  95
Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro 
             100                105                110
Thr Gly Phe Lys Pro Gly Lys Glu Phe Phe Pro Leu Asp Glu Ser Gly 
         115                120                125
Asn Val Val Pro Ser Asp Thr Asn Ile Leu Asp Thr Trp Ala Ala Met 
     130                135                140
Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser Asn 
 145                150                155                160
Phe Asn His Leu Gln Val Glu Met Ile Leu Asn Lys Pro Gly Leu Lys 
                 165                170                175
Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr Gln 
             180                185                190
Glu Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Val Val Thr Ala 
         195                200                205
Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu Asp 
     210                215                220
Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Ala Ile Ala Ala Lys His 
 225                230                235                240
Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Met Gln Arg Asn 
                 245                250                255
Leu Val Val Ile Pro Lys Ser Val Thr Pro Glu Arg Ile Ala Glu Asn 
             260                265                270
Phe Lys Val Phe Asp Phe Glu Leu Ser Ser Gln Asp Met Thr Thr Leu 
         275                280                285
Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Leu Ser Cys Thr 
     290                295                300
Ser His Lys Asp Tyr Pro Phe His Glu Glu Phe 
 305                310                315



<210> 3740
<211> 15627
<212> DNA
<213> Rattus norvegicus
<308> M60322
<400> 3740

ggatccagg  agttcaaat  gcagagaag  ctctatgcc  agagggatt  cacagagga  60
aagtggcgg  tgtcaggtc  cctgttatc  tacacaaac  taatcccca  cactacact  120
aaattcaaa  tctactatt  agagaaaaa  tacacaaga  cttccacat  ccaacagct  180
tggggtttt  ttttgttaa  aaaatccaa  tggaaaata  ctgttcttt  taaattttc  240
cagggatgg  agtggaaga  tgccacctt  taggagggc  ccaactgga  aatcaccag  300
atggcactt  gagaggtgg  gttcctgac  cattactct  cagatgcag  tgtctgtgt  360
gcataatca  gggggcgac  gaagcatga  ccagcagaa  gagactcag  caaaacaga  420
catcacgca  aggggtgtt  gaagagtgc  aaatttccg  cattgttct  ggggcaact  480
cgattattt  agggaaagt  tttgttttt  tacccaata  caactgatt  atttatttt  540
tgtcccctt  acttggaat  attgctgta  gaaaacgga  ttttcctag  atgggattc  600
gcctgttca  ttttcttcc  gagagagtt  ggtcaactt  ctatactgg  acctgcccg  660
tcaacagtt  tactttccc  aatcattta  gtgtgatcc  gagatcaag  ttatgaggg  720
ttatagcta  cggttgctg  gtttcgcat  aaggcttgt  gaaccagat  gagcatgtt  780
agacactgg  aatggtaga  agctactac  agcgggcat  ttgtagtat  ttgcaaagc  840
ggttacaat  atttcaatt  agggggctg  gggaggggg  ggcttaaat  cacctgaag  900
ttaactttt  acataagac  aaaaaaaaa  aaaaaaaaa  aaaaaaagc  cttaagtac  960
cctgacgcc  atctgctcc  tcagtttca  aacaagatg  gcaggattc  agaagagta  1020
tattctgag  ttagaaaaa  acacaagcg  ctttttctg  cctctaaaa  gaaaccaaa  1080
ccttttccc  gtctcctta  ctctagtct  ccggttatt  tcagagcgt  tagtctggt  1140
cttcaacag  aggcaaaca  tctgccacg  ggggcgcag  gcagctgga  aattccgtg  1200
ctctaggac  tagggaaag  agcatcctc  ctgaccctt  aaggaccac  gaagagacc  1260
atcagaagg  gccgtctct  agccgtgcg  caatcgcag  cgtcctttc  gcaggctgt  1320
ggggctatt  aaaggtgcg  gccggagcc  gcgctgcac  cttgcgggt  gttgtgcgt  1380
acttgcagc  atcatggct  gccatctgg  actcaacaa  ggcaccaag  tgcccaccc  1440
gggtctggg  acctggaag  taggtgctc  tcagggcgt  gcccgccac  cgctgggtg  1500
ccctgagcg  cctgcgcgg  gcggggctc  ggtggttgg  gcctgtggg  gcatccggc  1560
gcggccccg  gtgtggggc  ctgggcgag  attgcgcga  tccgcgtgg  tgccccagg  1620
ggagacaca  ccacggggg  gagaggaac  gaagcaggg  tctagattt  tcatctggc  1680
ccccaaact  acgagtgag  tgacctcac  tggagcaga  gttgccctc  cgggaatga  1740
ccacttggc  gataggcct  agataatta  attaggagg  gagagtttg  agtgaacca  1800
cctgtttct  ttttcctta  atcgctgag  gcagctctt  acgggtgcg  aactcctct  1860
gaattaatc  ggtttccgc  ttgctgggt  ccaccctcc  caaacccca  cacaacaca  1920
caggcttga  aagacggcc  gatacgtta  agtgaaata  aaaaagaaa  aaccgataa  1980
taaaaacta  aaattataa  tgatttgat  atttgaaaa  taaggaacc  gttttggtg  2040
tattgctga  gcagaaaaa  ccagctctt  agctactgc  gtgacctgg  tctttaaga  2100
cctggagta  gggtgaacc  gggctgtat  taagcactt  gacacagtg  aggaaagag  2160
aaatcatgc  gggttgagt  cagatggtt  gaaactgga  agtctgttt  tacccagac  2220
acagttaaa  tgggtaatg  atatggtga  taagaaaca  gtcatagac  tgtctttct  2280
tgaatgtgt  tctaagcca  tagattagc  agtgcggct  tcgtttcct  ccaaagggt  2340
cttggtgac  gtaaagatg  gattgaatg  gaaccatca  accagatta  attctatgc  2400
ttggaagga  aagaaagat  gtttccttg  tgtaataaa  acagcacag  aaaggcaca  2460
ataactaca  tggttttgt  atacacgac  ctcaacatg  gtgggatgc  gatacttta  2520
ttctgtccc  tttctctaa  aaccaagct  ataacttta  aaaagcatt  tgagatcag  2580
tctcgggta  acacgagta  acattcata  gccggtggc  agagcggat  caacagccc  2640
agagagctg  gtgtttgtt  aaaattaca  acattttaa  gtatagatc  ttctgccgc  2700
ttcacagat  ttcctgtca  ttcccgcag  gcctggctt  tagaatgga  ccagaagtc  2760
tgttgagtt  gggcagggt  aagaaaatg  ctgcctgtg  ctgggggca  ggggaggtt  2820
gtgcagaga  cgtggaggg  cgaagggtg  cagtgagag  caggaggac  gccgagact  2880
ccagatttc  ttttttttt  ttttttttt  tttggttct  tttttttcg  agctgggga  2940
cgaacccag  gccttgcgc  tcctaggca  gcgctctac  actgagcta  atccccagc  3000
cccagattt  cctttttaa  aaaagaata  caacttaat  ctttccttg  acatgtgtg  3060
cgttccttc  tagatgaca  agtatatca  agtcactgt  atggtcaca  agggtgtgt  3120
ggtgcggtc  cttgttctg  aacttcatc  gtggccacc  ggtacctca  agaccacag  3180
gggactctg  cagggtatg  tccactctt  ccttgaggg  atctgtttc  cctgggagg  3240
gaggatttg  ggcagttgg  agacactct  acttgcatg  actttcttc  tggccaact  3300
gcctgccct  tggaccccc  aaatgcatg  taaatatac  atattacat  aaaatactg  3360
tttaagttt  gtgtggtca  gaggccttt  aggcagagc  ggcctgata  agaccacca  3420
gccctttta  tgataatgt  ttgacctag  tgaaaatct  tgaaggaca  ggccattgt  3480
tcttccaca  ataggctag  aattgctgc  aggaatgta  ggacagctg  gttctcaga  3540
tattttcca  ttaatgccc  ctgtgcctc  aaaccatga  tctcttgag  tgaactttt  3600
ttttctttt  ggcctaatt  tatcccaat  ggattctgg  atctcagat  aaactacta  3660
atatgtgct  acgccctgt  ttccctttc  cagggtcac  tggcattct  aagctgtga  3720
atattttct  tgcttgctt  ttgagtgtg  tttttgcct  tctgggata  tagtacttg  3780
ccttagaag  aaactgtgc  agggtcctc  tgccatttc  tgagttaaa  caagtgtcc  3840
ctgacagtc  tagagcctg  ggtcaggga  aaatgctgt  ctcattgaa  taggagttt  3900
gttttctgg  ggcctgcca  tgaccaggc  acactcctc  acctttcca  atttaagat  3960
aaaaaaaaa  atcaaatat  tcttgtcta  gcagggccg  tcctggagc  acatctctg  4020
ggagtggag  tgtgtctta  aatccggac  gctttattg  ccgataaca  tagaacacg  4080
tttattagt  ttgttgcta  actaggctg  gggctttca  tgttctcag  ctggggaaa  4140
ggccattct  gagggttca  tcttcatct  ttggaatca  cgttaaagt  cttgaactg  4200
gaggcgagg  tataccatc  aaacaaaca  gtgaggctg  tttctctca  tccagcagt  4260
ggaagtgct  tttgtggcg  ctgggtagg  catgaaagg  ggcacattg  gatcattct  4320
ggggttttc  gtcagagac  tggggaggt  gtacattta  gcctgttta  taagccacc  4380
gggttctgg  ctgtgtggg  aggaagccc  tggaagcag  gttctttct  ctgacctgc  4440
ctttgagcc  ttatctgtc  ttgtctttc  gtgaaaaca  cacacagaa  ttttttcct  4500
tgggttttg  tttggcgtc  gatgttcca  gacgtcgct  agtgtagtg  tggtctgcg  4560
cagtgtagt  tcagtgcat  ctgcactct  gcttggagg  acagaaaag  caggttaac  4620
tcacgcaga  ggcaagcag  aaagttggg  taggggtgg  gcctcattg  aatagccat  4680
acagtcact  gattcacgg  ttggattcc  ttctgggtt  taaattagg  taccagaat  4740
gagacgttt  agaccccat  ctctcaagg  gttgcgagc  ctcattctc  cagcaaagg  4800
ctccaggat  attcctcag  gggtgggcg  aggtcctga  atggagtac  atagccccg  4860
tcggctcac  ccatgttcc  gcttctgtg  gagtggctg  ggcaaatgt  gggtggctt  4920
gcccagcct  gaccttgtg  ccagcgctc  atccaaagc  aagctctgc  aggctctaa  4980
taggcttcc  acaaggcga  catgagagt  agcacaagg  ccctggatc  tgctataaa  5040
tcatcgtat  tccgaggca  gagaaacac  cacacactc  ccaggcccc  cttgtgtgg  5100
ctttctcaa  cagggattt  ccttttccc  cacagctag  accagccat  gctgtgtct  5160
gctgcccca  agggccctg  ccgggagag  ctttccctg  ataggccga  atagttcct  5220
taaccacag  aggaacctg  ggagaagct  agctacagg  gcactcttg  gtcctccag  5280
gaaatgaga  gggggccaa  cagtctaaa  gcacgtagt  aaggtaact  agtcctaag  5340
acgctgtgg  ccttccacc  ggcaggtcc  tccccactg  gtgaggagc  aagaccact  5400
cccacaggt  ctggggatg  gcttcttct  ctgtttgct  ttttatccc  tgactgttt  5460
gttcacaag  ctccagaca  aacagacgt  ggcggctgc  gatggcctt  gggagtttt  5520
tttttcatc  gattttgcc  cagctcgcc  gaggaatgt  ctgtgttcg  tcagcggcg  5580
ccagcgcag  gtcttgttt  gctctctag  cttggcaag  gcagcctgg  gatgggtaa  5640
agtgctgtg  agtccgggg  ctggtgaag  tcaggacta  gcaggctcc  cctcttctt  5700
ctcctcctc  gtggccagg  ttctcacgt  ccttaccaa  ctcaggtga  aatcttgca  5760
ggagccatc  tccctttcc  ctcacttct  tctgctgtt  cctctgaga  accacgtgt  5820
catgtccgt  cccacctcc  gggtcagca  cagttgagc  cttgttctg  gataaatgc  5880
atgaactat  tgagtgaaa  ggtgccttt  gttacatag  tcttggcta  tgctttttt  5940
tttttcttt  ttctgacca  gctacccca  acctcacag  gttcatgct  ctgccttca  6000
aggatcata  ctaggctgc  ggcctgtgg  tgtcaggct  tgctgaggt  aaattgaca  6060
ccctgtcgg  ggctgactg  aatgctgta  cataaatgc  tgttggcct  acatggcct  6120
acctcagaa  aggagcctg  tccaggatt  ctaacccca  tgtcctttc  cggctctgg  6180
caggcacgg  tctgtttgg  ttgggtttt  atcgatgac  gacattcct  cctttgcag  6240
ctcctcctg  ccaggtgac  gaggctgtg  aggttgcta  cgacatggg  tatcgccac  6300
ttgactgcg  ccaggtgta  cagaatgag  aggaggtgg  ggtggccct  caggagaag  6360
tcaaggagc  ggtggtgaa  cgccaggat  tcttcattg  cagcaaggt  ccaccaatc  6420
gtgaggatg  tggggtcca  ttcactccc  gccaggggg  cccagctgc  agtcaggtc  6480
acccttaac  tgatggcgg  tagtgctgg  cgggtggtg  acctgttac  tgtccacct  6540
tgtatctct  tgctgggcc  gtagatgag  gcctggttg  gggttgact  gcccttgta  6600
ggagtgact  cagggacag  gttaagtta  ttgacaaac  gggtttcac  gctggcctt  6660
agttttagc  agaggctgt  gatgtacaa  ggagcccag  ttggagggc  atgctggct  6720
catgtggac  agcttggct  ggaagtaga  ctagagcat  tgtttagca  ctcctgatc  6780
acagccgtg  ctcgtttag  ctctgtgag  tgctcttga  ctgaccacc  cacttgcct  6840
tgggaagtt  ggatccgca  tatgaactg  aaactctcc  gctactcct  gcgtcatgg  6900
tatggggag  ggagagcat  tgtgtcctc  gccttggga  tgtgtggct  ccagccggg  6960
agaggcatt  gcatggcag  gtaacctgt  ccgtttgct  gctccagct  tggtgcacg  7020
tccacgacc  gagcatggt  aaaggggcc  gccagaaga  gctgagcga  ctgcagctg  7080
actacctgg  cctctacct  attcactgg  caactggct  caaggtgag  ggcacacgg  7140
ggctggatc  gagcggttc  ggtgcggtc  tctctttct  ctcagcacc  tataggtgc  7200
tgactcatc  tgtctctgc  gcttggggt  tgcttctgg  ccagcatca  cgtcatcac  7260
taaaacgta  tagaaacca  cttcaggcc  ctctgcact  tctgaagcg  tggtggctc  7320
gatgcagcc  ttggagtct  ggggacacc  ctcttttca  tcagtgcct  cagaactta  7380
aactgacag  aaatatggc  gacaggact  ctgttgtcc  tgttgcaca  ggctgtagg  7440
gaagcctgc  ccgctgagt  tcctctggg  cttacatgt  atgcacgcc  gcgcgcgcg  7500
gcgcacgca  acacacaca  acacacaca  acacacaca  acacacaca  atgagtctg  7560
acctccgtt  catgccagt  tcatttgtg  ggtgacccg  agatctcag  gtcacttct  7620
gtatttctg  gtggtgacc  agatggaaa  gtcactggt  ttatcctcc  ctctgtttt  7680
gcttaccat  gtctcttgg  gcccgaggg  ctagatttt  accctgtgt  ttttatgac  7740
agccagaaa  agagaggca  agtgatagc  ttctaggtc  gagagccac  gagactcac  7800
gtgcctgag  ttccctacc  tgcccacag  cccttctcc  tgtcaggct  gggctcaga  7860
acttggata  gtctgaatc  ccatttgac  ccctcacag  tccagtcat  acagggatt  7920
ccatcgggg  cactttctg  ttccttttc  tcttggcta  cagatatac  tcttaccat  7980
ttccacagt  tgtagtgct  tgagattaa  aagtctgtg  agaagtgtc  ctgatgatt  8040
tgtgtgtgt  cttgttgtt  ctgacagcc  gggcctgac  atttccccc  ggatgcatc  8100
ggaaacgtg  ttcctagtg  caccgattt  gtggacact  ggacggtaa  atgcccctg  8160
ctgagaccc  tgtttattg  tggtaccct  ttattgtgt  caagccagg  gtgagtgat  8220
tgctctgcc  tgtcctgtg  ttagatcat  ccgtctctg  gtctgtctg  taagtctcg  8280
gaaagccag  ccagttttc  tcttggctt  tgaaagata  aagggtctg  ccgcggatg  8340
gagggctca  ctgtaaagt  ctggacaca  acatgcttc  ggttcttgt  ctcttggag  8400
tcattttag  actcagatc  cttttcttt  taggctatg  agcaactag  ggatgaagg  8460
ttggtaaaa  caatcggag  ctccaactt  aaccctctt  agattgaga  gatcttgaa  8520
aaacctggc  taaagtata  gcctgctgt  aaccaggta  gcgtcccca  gggaggatg  8580
tggcatgct  ttttaccag  cctggctct  gcctgtgga  cacagagag  agaagctct  8640
cagggatag  atttgaggc  agtcagcaa  gacgtggct  ctaacataa  ccgtgggta  8700
ctggtgaga  ctgcaggct  ttatctatt  ataatggcc  aggccaggg  aggccttat  8760
ggcttatgg  catagagca  tggcaacaa  attattctt  ctcttaatg  gaaggccat  8820
agctgggaa  tgtggagag  tgttccagc  tatctggga  gcagacatt  ctgtgtggg  8880
agaaaaggg  cattgacca  gtcacatga  tttgtgtcc  ctgccacag  cacccctcc  8940
gcttgtgtt  cagatcgag  gccacccat  cctaactca  gagaagctg  ttgagtact  9000
ccattgcaa  ggcatcgtg  tgactgcat  cagtcccct  ggttctcct  acaggccct  9060
gtgagcttc  gtgggagca  tgttggaga  aagaaataa  caaagggaa  gattggttg  9120
cagagagaa  gcttctgtg  tggctgcag  ccttccgtg  gtcctctgg  cttcctggg  9180
ggttcatgt  tctaggagc  agagatgga  atatattct  ttgcaaagg  tcagcaggt  9240
gatcatgac  cagcttcgg  ctaggagcc  gaccaacca  ccaggagtc  gtgggagga  9300
cagggctag  tggccggct  ccttgagtg  cagtggtga  gattgttga  ttccccatc  9360
ctctgctcc  gggccaagc  tgaggaccc  tctctcctg  aggatccca  gatcaagga  9420
attgcagcc  agtacaata  aactacagc  caggtatgg  tgcttcttg  tacttttga  9480
tgaactcta  actcacagt  gtccctgtc  gtcaggagt  gagggggct  agcctgaag  9540
cctctgtgg  agtgtggtt  ggagtccta  aatgcagtt  aggggcaca  atgtagaaa  9600
tgagagaat  aagtgacac  tggccctgg  acaatagtg  ctgtcccca  cgtctctat  9660
tgcggcaca  gcatcagcc  agcgtttag  gctgttctt  gaagctctt  ccggttact  9720
atagaagag  tcttactgc  tgcggtgtg  gaggtgttc  ctttcttcc  ggggtagtg  9780
gaccaggca  tgacttcct  tggccttgt  acatgcctg  agccactga  ggagcagga  9840
tgtagggtc  gatttgcac  aactcgtgg  tgtcacttg  cgtctcaca  cctctttgc  9900
tgtgcactt  ttgactgag  tggtaacac  gtgtattta  acactccac  cctctgcat  9960
cgcaggtgc  gatccggtt  cccatccaa  ggaacctgg  cgtgatccc  aagtctgtg  10020
caccagcac  tattgctga  aactttaag  taagatccc  gctccaggc  tggctttcc  10080
ccatggcag  tgggtcctg  gggttctcg  cctcccctt  ctttcccag  tgtgtgatt  10140
cgagcaagt  acttgacta  actcaaaac  gtgcctatg  tgagggctg  ggtgagact  10200
aagttcgtg  tgcacacgc  acagcactt  atagccctg  ttccacact  agtgctcag  10260
aaacattgc  gtgctggtg  tgggtccat  gacgcccag  acatacacc  atccactgg  10320
tctgttaag  cctaagcag  catgagcag  ggtgggaat  cttgggcac  aggagtgta  10380
gcatggaga  tgccctacc  ccaccactg  agcagctca  gctacctgg  gagaggcta  10440
ctgggaaag  gctgctcca  gacggtcct  ggaccacat  acaggagcc  ctggcccgt  10500
aaagcaaag  gatgctctg  cgaagtctg  ttcaaagtc  gccccacag  gtccacaat  10560
ggcactaga  tggttctga  gacatagta  gctactcta  tcctacctc  tcctcgtga  10620
cgtgaccat  cataccact  acatgtaac  atgtgggac  agagacatg  cctgctaga  10680
atgggttaa  acctcaccc  ataattcat  tctaaagta  tagggaaga  aacacagcc  10740
ggcggtggt  gcgcacacc  ttaatccca  cacttggga  tcagaggca  gtggatctg  10800
gagtttgag  ccagcctgg  ttgcagagc  agttccagg  cagccaggg  tacacagag  10860
aactgtctt  aaaaagaag  aagaatgtc  gtgaccaat  ttaacccac  gacctagtg  10920
ttcgttttt  tttgtttct  tttttcatc  tactgtgca  tttgcttgt  tctccatgg  10980
tgcagtcac  agagaatgt  gcagagtct  gtcctgcac  ttccgccat  agaatgtgc  11040
aagtggagt  ggttgtcag  gtgcagctc  atttccaag  cctggtgct  cggaaggcc  11100
tctggtcta  ttgtccacc  tgtacccta  cttcttttc  gtattctgt  gtggggtat  11160
caccggaga  gactaagca  acatgagtt  aaacaagta  aaagtcttt  ttagccagc  11220
tgtgactac  ctgggtgtt  gggatccca  gcctttctc  gggtttaag  acacaatca  11280
atcttgggt  tgatacacc  cagttaaca  gaacaatta  ccagaggta  aactgcaga  11340
gccagaagg  gaggctagc  catgtagag  cttttccag  actatggac  ttgatgtga  11400
ttaaaaata  aaacaaaca  aaaaattag  aaggaaagg  catgactgc  cctgaaccg  11460
ggggttggg  tgaggggga  caagtacaa  agccaggaa  ccaaaggta  aaaaggagc  11520
aagtgggta  taagggaac  gtcgggctg  ataggggag  ggctggaga  ctgagtaga  11580
ggtgggtgt  cccgccaca  cctgtaatt  gtagggact  aagggtatt  aacctggag  11640
ccaggtctg  ttagctacc  taaataggc  ccttagacg  ttgccctgg  attgaaatt  11700
aacagcagg  tagccccag  tctggcaca  aacacccca  gactgtaat  catccttca  11760
cttcacctt  gctgggtgt  ttgcttggt  tttgatttg  ctgacggtg  tgtgtacct  11820
ctgagtttt  tgacttgaa  ggtacttcc  tccatcatg  agtcagtgt  ctagggtct  11880
ttacatatt  ctgtattca  tcttttgtc  tcgtggaag  ctttcttgc  ctgtatgtc  11940
aaacctgac  tattttctt  ggccttgtc  cacatggat  cgcgaggca  tgtccttcg  12000
tccccagct  gagtgcctt  ctggggaca  cccagagcc  ttctttcat  acagcgcag  12060
acccagaac  cggattaat  ggtgttcca  ctattgagg  gtctcctct  acacttctg  12120
tgaatggag  agtcaggac  ctcagtaac  tttcccctg  tgcttatca  agtagagcg  12180
ctcaggagc  tgacaggaa  gactgaaca  tgccctctg  ttggaaatc  tggaaggga  12240
aggccattt  agatagggc  acaagcctg  accttctgg  gcataatta  cagtcttct  12300
gaagtccca  gtcctctcc  gccctctgc  ctccaggca  tgagggcca  ctggaactt  12360
ctgctttgt  tctgtttta  tgtgagctt  ttgactttg  ttctttcct  catgtttgt  12420
tgtaaggtc  ttgactttg  gctgagcaa  gaggacatg  ccactctac  cagctacaa  12480
aggaactgg  gggtgtgcg  cttgatgag  tgagttcca  tgtggtgcc  gttctacct  12540
ttctatgtc  ccaaatgtt  agactaaca  gcatctctc  ggccccaga  gcagggtcc  12600
tcccctgca  cccgccctg  tttcacaca  accttgtct  ctaatctat  cagacccgg  12660
ggcactgca  aaagccagg  gagggtggc  gtcaggaga  ctgcctggg  gcacagttg  12720
tccactttg  cttttctga  ctcagatgg  cccaggggc  tctctggta  ccaccttcc  12780
agaagagtt  gcatgtgac  gattgactt  atgacgcta  cgaggagtt  ggtaggaag  12840
ccctggtgc  gggctcagg  tagccccag  tctggcaca  aacaccctg  gactgtaat  12900
ccactcaga  ggctgtaat  ccactcaga  ggctgtaat  ccactcaga  ggcttaatg  12960
cactcgggc  cccagggcc  ttcagcttc  cctctgctg  ttttttgct  ccctctgaa  13020
tggggtttg  actccgaat  cctggggat  agtttgctt  aagaagcag  ctgtgtccc  13080
aatgcctgc  ttgtcttcc  gtcttgatt  tcactcaca  tctcttgct  tcactcgcc  13140
tctgcataa  tcggtgttt  cctggtggt  gccgcaacc  ctacggtct  tataggcag  13200
aaggtttgt  attcgggct  tttacatgt  gccatcaca  agtcctcag  ttctaagta  13260
gctgtaaac  gaactagcc  aggactctg  aacaggacc  tttctgata  tacactaag  13320
acgtttaac  ttttaatgt  aaaatcatc  tttactttg  atctaacgg  caggagaga  13380
gcgaatcac  tgcctgtag  atccatccg  ttcctagag  ctgtagtag  taagtcact  13440
agccctgcg  gttccctgg  actgctgat  ctgacatca  agcttgtgg  gagagcaaa  13500
cctttgtgt  tgctcacct  cttgcacct  ccatgacta  tctagaagc  gctgtgctt  13560
gacagtact  agttgacat  ggttgcagt  ggggttggg  caggggcgg  ctctagtgc  13620
cccagcaaa  ctttcctaa  atgccagcc  tcctgtgga  acacacggc  atactgagc  13680
cttgctgct  gtgtctgag  ccaggatgc  aagaaaggc  gttgcgggg  agcttgagt  13740
atctgagtg  tcagtgaga  ctgcatacc  ggggcctgg  tcatcctca  cctctgggg  13800
gtggaaaga  acgagcagt  cacttttgc  tggattcta  aagagaagc  caacctcag  13860
cgaaaacat  ctcatcttc  gaggagtag  gcaaccttt  ttagtttga  ttgattaag  13920
aagaaatga  ctttcttat  tttgattta  cttcctgct  ttctccaaa  agcaggagc  13980
gtctgggac  tcatggtat  gtctctgat  ttttattgc  gaattaact  gattttttt  14040
taatgtgag  gtgtgtgtg  cacactagt  gtcctttga  tccaacatg  gcgcgcacg  14100
gcacacaca  acacacaca  acacacaca  acacacaca  acacacaca  acacacaca  14160
acacacacg  gttcaggct  tgacactgt  cctgcctag  ttctctagt  ttcttgcca  14220
tttgttccc  ttataagcc  ttggcccta  caaatagac  gtgaacctt  gctccatgc  14280
agcccttgc  ctgttcctg  agtacatcc  cagctgctg  taggtgctc  tttcactcc  14340
gatgtcaca  aggggcctc  cctttcctg  gagtggctg  ctgtttgac  tgcccttca  14400
ggttcagtg  ggtacagct  gtaaaccct  ctactgctt  gttatctct  ttcttttgg  14460
cctgtgttc  ggagctgat  aaatgaact  ggtgtagtg  cacacgcct  taatcccag  14520
acttgggag  tggagtcag  aagacctga  cttcaaggt  atcctcagc  aagcagtgt  14580
tttgaggcc  gccccgcct  accagaccc  gtcttaaaa  acagcagaa  gttgacatg  14640
ggctgtatg  tcctgccag  tcctcagag  tcccacgca  gacttgctg  ccagtgtgc  14700
ccaggctag  gcttagtgc  gcctgtcac  tgatgcagt  cctgacatc  caagacaag  14760
ggagctcag  gcctgagta  ctgtaccta  gatcagaag  ctctaagac  gctcagtcc  14820
cagtgagac  ccgtttctc  gtgttggtg  ctcgttcgt  acagacaga  tctttttcc  14880
tgagagctg  caaggtggt  cagagtgtt  agacatttg  atcaatcct  aggataaac  14940
gagtttatc  aggacccac  cgataggag  gaagcaact  acactaaat  aataagtga  15000
cccaattaa  tttaggaag  ctttaactt  taaattgca  gtattcttt  ctgacagct  15060
tgccaaaca  aaggattac  ccttccacg  agaagtctg  agctgtggt  gacgaatcc  15120
gctcctccc  aagcgactt  acacatgtt  tttctgcct  atctgccct  gcaagtgtc  15180
ctctgcact  ggtggcacc  tgcagacca  atggtgaga  tttgttagt  tgacgtaga  15240
tgtggaggg  agtaccagt  gctgaggag  ttcttcggc  tttcttggt  ttcttccca  15300
ctggaggac  ttaacacga  taccttttc  aaccaaaga  aaagcaaga  ttatagccc  15360
agtcatgcc  ctaacactt  aatttgagt  cttagaact  cagtcctat  ggggtcaga  15420
tttttgcct  aaataaaaa  tgcttttgt  aatttggtg  tcgtctgtt  tgcttttgc  15480
ctgtaatac  gtgcacccc  tctgcccca  acccagcct  agtgccaag  acaggccag  15540
gctgtgaac  aactgagaa  tcgtatcct  gcacgacac  gcagagtgt  agggtggtg  15600
gtagcatcc  ggtgacatg  tgagctc  15627



<210> 3741
<211> 315
<212> PRT
<213> Rattus norvegicus
<308> AAA40721
<400> 3741

Ala Ser His Leu Glu Leu Asn Asn Gly Thr Lys Met Pro Thr Leu Gly 
  1               5                  10                  15
Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val Lys 
             20                  25                  30
Val Ala Ile Asp Met Gly Tyr Arg His Ile Asp Cys Ala Gln Val Tyr 
         35                  40                  45
Gln Asn Glu Lys Glu Val Gly Val Ala Leu Gln Glu Lys Leu Lys Glu 
     50                  55                  60
Gln Val Val Lys Arg Gln Asp Leu Phe Ile Val Ser Lys Leu Trp Cys 
 65                  70                  75                  80
Thr Phe His Asp Gln Ser Met Val Lys Gly Ala Cys Gln Lys Thr Leu 
                 85                  90                  95
Ser Asp Leu Gln Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro 
             100                105                110
Thr Gly Phe Lys Pro Gly Pro Asp Tyr Phe Pro Leu Asp Ala Ser Gly 
         115                120                125
Asn Val Ile Pro Ser Asp Thr Asp Phe Val Asp Thr Trp Thr Ala Met 
     130                135                140
Glu Gln Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Val Ser Asn 
 145                150                155                160
Phe Asn Pro Leu Gln Ile Glu Arg Ile Leu Asn Lys Pro Gly Leu Lys 
                 165                170                175
Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr Gln 
             180                185                190
Glu Lys Leu Ile Glu Tyr Cys His Cys Lys Gly Ile Val Val Thr Ala 
         195                200                205
Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu Asp 
     210                215                220
Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Glu Ile Ala Ala Lys Tyr 
 225                230                235                240
Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Ile Gln Arg Asn 
                 245                250                255
Leu Val Val Ile Pro Lys Ser Val Thr Pro Ala Arg Ile Ala Glu Asn 
             260                265                270
Phe Lys Val Phe Asp Phe Glu Leu Ser Asn Glu Asp Met Ala Thr Leu 
         275                280                285
Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Met Ser Cys Ala 
     290                295                300
Lys His Lys Asp Tyr Pro Phe His Ala Glu Val 
 305                310                315



<210> 3742
<211> 1367
<212> DNA
<213> Homo sapiens
<308> NM_001628
<400> 3742

gaaggccgc  ccgtactgg  cgggggtct  gggagcgca  cagccatgg  aagccgtct  60
ctgctcaac  acggcgcca  gatgcccat  ctggggttg  gtacctgga  gtcccctcc  120
gggcaggtg  ctgaggccg  gaaggtggc  attgacgtc  ggtaccgcc  catcgactg  180
gcccatgtg  accagaatg  gaatgaggt  ggggtggcc  ttcaggaga  gctcaggga  240
caggtggtg  agcgtgagg  gctcttcat  gtcagcaag  tgtggtgca  gtaccatga  300
aagggcctg  tgaaaggag  ctgccagaa  acactcagc  acctgaagc  ggactacct  360
gacctctac  ttattcact  gccgactgg  tttaagcct  ggaaggaat  tttcccatt  420
gatgagtcg  gcaatgtgg  tcccagtga  accaacatt  tggacacgt  ggcggccat  480
gaagagctg  tggatgaag  gctggtgaa  gctattggc  tctccaact  caaccatct  540
caggtggag  tgatcttaa  caaacctgg  ttgaagtat  agcctgcag  taaccagat  600
gagtgccac  catatctca  tcaggagaa  ttaatccag  actgccagt  caaaggcat  660
gtggtgacc  cctacagcc  cctcggctc  cctgacagg  cctgggcca  gcccgagga  720
ccttctctc  tggaggatc  caggatcaa  gcgatcgca  ccaagcaca  taaaactac  780
gcccaggtc  tgatccggt  ccccatgca  aggaacttg  tggtgatcc  caagtctgt  840
acaccagaa  gcattgctg  gaactttaa  gtctttgac  ttgaactga  cagccagga  900
atgaccacc  tactcagct  caacaggaa  tggagggtc  gtgccttgt  gagctgtac  960
tcccacaag  attacccct  ccatgaaga  ttttgaagc  gtggttgcc  gctcgtccc  1020
aagtgacct  tacctgtgt  tcttgcctc  tttttttcc  tgcaaatgt  gtatggcct  1080
tgtcactca  cagtgggac  gcaacctgt  gagtggcca  cgagggcgt  tctagcttg  1140
tgttggatc  caagagccc  gtcagtaga  tagaagtct  ttccagttt  ctttgccct  1200
ctttctacc  tgctgggga  agtacaacc  gaataccct  ttctgacca  agagaagca  1260
aatctacca  gtcaaaata  tgccactaa  ggttgagtt  tgactgctt  gaactggaa  1320
cctttcagc  agacttctc  ttgcctcaa  taaaaagtg  ttttgtg  1367



<210> 3743
<211> 315
<212> PRT
<213> Homo sapiens
<308> P15121
<400> 3743

Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu Gly 
  1               5                  10                  15
Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val Lys 
             20                  25                  30
Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val Tyr 
         35                  40                  45
Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg Glu 
     50                  55                  60
Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Leu Trp Cys 
 65                  70                  75                  80
Thr Tyr His Glu Lys Gly Leu Val Lys Gly Ala Cys Gln Lys Thr Leu 
                 85                  90                  95
Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro 
             100                105                110
Thr Gly Phe Lys Pro Gly Lys Glu Phe Phe Pro Leu Asp Glu Ser Gly 
         115                120                125
Asn Val Val Pro Ser Asp Thr Asn Ile Leu Asp Thr Trp Ala Ala Met 
     130                135                140
Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser Asn 
 145                150                155                160
Phe Asn His Leu Gln Val Glu Met Ile Leu Asn Lys Pro Gly Leu Lys 
                 165                170                175
Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr Gln 
             180                185                190
Glu Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Val Val Thr Ala 
         195                200                205
Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu Asp 
     210                215                220
Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Ala Ile Ala Ala Lys His 
 225                230                235                240
Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Met Gln Arg Asn 
                 245                250                255
Leu Val Val Ile Pro Lys Ser Val Thr Pro Glu Arg Ile Ala Glu Asn 
             260                265                270
Phe Lys Val Phe Asp Phe Glu Leu Ser Ser Gln Asp Met Thr Thr Leu 
         275                280                285
Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Leu Ser Cys Thr 
     290                295                300
Ser His Lys Asp Tyr Pro Phe His Glu Glu Phe 
 305                310                315



<210> 3744
<211> 15627
<212> DNA
<213> Rattus norvegicus
<308> M60322
<400> 3744

ggatccagg  agttcaaat  gcagagaag  ctctatgcc  agagggatt  cacagagga  60
aagtggcgg  tgtcaggtc  cctgttatc  tacacaaac  taatcccca  cactacact  120
aaattcaaa  tctactatt  agagaaaaa  tacacaaga  cttccacat  ccaacagct  180
tggggtttt  ttttgttaa  aaaatccaa  tggaaaata  ctgttcttt  taaattttc  240
cagggatgg  agtggaaga  tgccacctt  taggagggc  ccaactgga  aatcaccag  300
atggcactt  gagaggtgg  gttcctgac  cattactct  cagatgcag  tgtctgtgt  360
gcataatca  gggggcgac  gaagcatga  ccagcagaa  gagactcag  caaaacaga  420
catcacgca  aggggtgtt  gaagagtgc  aaatttccg  cattgttct  ggggcaact  480
cgattattt  agggaaagt  tttgttttt  tacccaata  caactgatt  atttatttt  540
tgtcccctt  acttggaat  attgctgta  gaaaacgga  ttttcctag  atgggattc  600
gcctgttca  ttttcttcc  gagagagtt  ggtcaactt  ctatactgg  acctgcccg  660
tcaacagtt  tactttccc  aatcattta  gtgtgatcc  gagatcaag  ttatgaggg  720
ttatagcta  cggttgctg  gtttcgcat  aaggcttgt  gaaccagat  gagcatgtt  780
agacactgg  aatggtaga  agctactac  agcgggcat  ttgtagtat  ttgcaaagc  840
ggttacaat  atttcaatt  agggggctg  gggaggggg  ggcttaaat  cacctgaag  900
ttaactttt  acataagac  aaaaaaaaa  aaaaaaaaa  aaaaaaagc  cttaagtac  960
cctgacgcc  atctgctcc  tcagtttca  aacaagatg  gcaggattc  agaagagta  1020
tattctgag  ttagaaaaa  acacaagcg  ctttttctg  cctctaaaa  gaaaccaaa  1080
ccttttccc  gtctcctta  ctctagtct  ccggttatt  tcagagcgt  tagtctggt  1140
cttcaacag  aggcaaaca  tctgccacg  ggggcgcag  gcagctgga  aattccgtg  1200
ctctaggac  tagggaaag  agcatcctc  ctgaccctt  aaggaccac  gaagagacc  1260
atcagaagg  gccgtctct  agccgtgcg  caatcgcag  cgtcctttc  gcaggctgt  1320
ggggctatt  aaaggtgcg  gccggagcc  gcgctgcac  cttgcgggt  gttgtgcgt  1380
acttgcagc  atcatggct  gccatctgg  actcaacaa  ggcaccaag  tgcccaccc  1440
gggtctggg  acctggaag  taggtgctc  tcagggcgt  gcccgccac  cgctgggtg  1500
ccctgagcg  cctgcgcgg  gcggggctc  ggtggttgg  gcctgtggg  gcatccggc  1560
gcggccccg  gtgtggggc  ctgggcgag  attgcgcga  tccgcgtgg  tgccccagg  1620
ggagacaca  ccacggggg  gagaggaac  gaagcaggg  tctagattt  tcatctggc  1680
ccccaaact  acgagtgag  tgacctcac  tggagcaga  gttgccctc  cgggaatga  1740
ccacttggc  gataggcct  agataatta  attaggagg  gagagtttg  agtgaacca  1800
cctgtttct  ttttcctta  atcgctgag  gcagctctt  acgggtgcg  aactcctct  1860
gaattaatc  ggtttccgc  ttgctgggt  ccaccctcc  caaacccca  cacaacaca  1920
caggcttga  aagacggcc  gatacgtta  agtgaaata  aaaaagaaa  aaccgataa  1980
taaaaacta  aaattataa  tgatttgat  atttgaaaa  taaggaacc  gttttggtg  2040
tattgctga  gcagaaaaa  ccagctctt  agctactgc  gtgacctgg  tctttaaga  2100
cctggagta  gggtgaacc  gggctgtat  taagcactt  gacacagtg  aggaaagag  2160
aaatcatgc  gggttgagt  cagatggtt  gaaactgga  agtctgttt  tacccagac  2220
acagttaaa  tgggtaatg  atatggtga  taagaaaca  gtcatagac  tgtctttct  2280
tgaatgtgt  tctaagcca  tagattagc  agtgcggct  tcgtttcct  ccaaagggt  2340
cttggtgac  gtaaagatg  gattgaatg  gaaccatca  accagatta  attctatgc  2400
ttggaagga  aagaaagat  gtttccttg  tgtaataaa  acagcacag  aaaggcaca  2460
ataactaca  tggttttgt  atacacgac  ctcaacatg  gtgggatgc  gatacttta  2520
ttctgtccc  tttctctaa  aaccaagct  ataacttta  aaaagcatt  tgagatcag  2580
tctcgggta  acacgagta  acattcata  gccggtggc  agagcggat  caacagccc  2640
agagagctg  gtgtttgtt  aaaattaca  acattttaa  gtatagatc  ttctgccgc  2700
ttcacagat  ttcctgtca  ttcccgcag  gcctggctt  tagaatgga  ccagaagtc  2760
tgttgagtt  gggcagggt  aagaaaatg  ctgcctgtg  ctgggggca  ggggaggtt  2820
gtgcagaga  cgtggaggg  cgaagggtg  cagtgagag  caggaggac  gccgagact  2880
ccagatttc  ttttttttt  ttttttttt  tttggttct  tttttttcg  agctgggga  2940
cgaacccag  gccttgcgc  tcctaggca  gcgctctac  actgagcta  atccccagc  3000
cccagattt  cctttttaa  aaaagaata  caacttaat  ctttccttg  acatgtgtg  3060
cgttccttc  tagatgaca  agtatatca  agtcactgt  atggtcaca  agggtgtgt  3120
ggtgcggtc  cttgttctg  aacttcatc  gtggccacc  ggtacctca  agaccacag  3180
gggactctg  cagggtatg  tccactctt  ccttgaggg  atctgtttc  cctgggagg  3240
gaggatttg  ggcagttgg  agacactct  acttgcatg  actttcttc  tggccaact  3300
gcctgccct  tggaccccc  aaatgcatg  taaatatac  atattacat  aaaatactg  3360
tttaagttt  gtgtggtca  gaggccttt  aggcagagc  ggcctgata  agaccacca  3420
gccctttta  tgataatgt  ttgacctag  tgaaaatct  tgaaggaca  ggccattgt  3480
tcttccaca  ataggctag  aattgctgc  aggaatgta  ggacagctg  gttctcaga  3540
tattttcca  ttaatgccc  ctgtgcctc  aaaccatga  tctcttgag  tgaactttt  3600
ttttctttt  ggcctaatt  tatcccaat  ggattctgg  atctcagat  aaactacta  3660
atatgtgct  acgccctgt  ttccctttc  cagggtcac  tggcattct  aagctgtga  3720
atattttct  tgcttgctt  ttgagtgtg  tttttgcct  tctgggata  tagtacttg  3780
ccttagaag  aaactgtgc  agggtcctc  tgccatttc  tgagttaaa  caagtgtcc  3840
ctgacagtc  tagagcctg  ggtcaggga  aaatgctgt  ctcattgaa  taggagttt  3900
gttttctgg  ggcctgcca  tgaccaggc  acactcctc  acctttcca  atttaagat  3960
aaaaaaaaa  atcaaatat  tcttgtcta  gcagggccg  tcctggagc  acatctctg  4020
ggagtggag  tgtgtctta  aatccggac  gctttattg  ccgataaca  tagaacacg  4080
tttattagt  ttgttgcta  actaggctg  gggctttca  tgttctcag  ctggggaaa  4140
ggccattct  gagggttca  tcttcatct  ttggaatca  cgttaaagt  cttgaactg  4200
gaggcgagg  tataccatc  aaacaaaca  gtgaggctg  tttctctca  tccagcagt  4260
ggaagtgct  tttgtggcg  ctgggtagg  catgaaagg  ggcacattg  gatcattct  4320
ggggttttc  gtcagagac  tggggaggt  gtacattta  gcctgttta  taagccacc  4380
gggttctgg  ctgtgtggg  aggaagccc  tggaagcag  gttctttct  ctgacctgc  4440
ctttgagcc  ttatctgtc  ttgtctttc  gtgaaaaca  cacacagaa  ttttttcct  4500
tgggttttg  tttggcgtc  gatgttcca  gacgtcgct  agtgtagtg  tggtctgcg  4560
cagtgtagt  tcagtgcat  ctgcactct  gcttggagg  acagaaaag  caggttaac  4620
tcacgcaga  ggcaagcag  aaagttggg  taggggtgg  gcctcattg  aatagccat  4680
acagtcact  gattcacgg  ttggattcc  ttctgggtt  taaattagg  taccagaat  4740
gagacgttt  agaccccat  ctctcaagg  gttgcgagc  ctcattctc  cagcaaagg  4800
ctccaggat  attcctcag  gggtgggcg  aggtcctga  atggagtac  atagccccg  4860
tcggctcac  ccatgttcc  gcttctgtg  gagtggctg  ggcaaatgt  gggtggctt  4920
gcccagcct  gaccttgtg  ccagcgctc  atccaaagc  aagctctgc  aggctctaa  4980
taggcttcc  acaaggcga  catgagagt  agcacaagg  ccctggatc  tgctataaa  5040
tcatcgtat  tccgaggca  gagaaacac  cacacactc  ccaggcccc  cttgtgtgg  5100
ctttctcaa  cagggattt  ccttttccc  cacagctag  accagccat  gctgtgtct  5160
gctgcccca  agggccctg  ccgggagag  ctttccctg  ataggccga  atagttcct  5220
taaccacag  aggaacctg  ggagaagct  agctacagg  gcactcttg  gtcctccag  5280
gaaatgaga  gggggccaa  cagtctaaa  gcacgtagt  aaggtaact  agtcctaag  5340
acgctgtgg  ccttccacc  ggcaggtcc  tccccactg  gtgaggagc  aagaccact  5400
cccacaggt  ctggggatg  gcttcttct  ctgtttgct  ttttatccc  tgactgttt  5460
gttcacaag  ctccagaca  aacagacgt  ggcggctgc  gatggcctt  gggagtttt  5520
tttttcatc  gattttgcc  cagctcgcc  gaggaatgt  ctgtgttcg  tcagcggcg  5580
ccagcgcag  gtcttgttt  gctctctag  cttggcaag  gcagcctgg  gatgggtaa  5640
agtgctgtg  agtccgggg  ctggtgaag  tcaggacta  gcaggctcc  cctcttctt  5700
ctcctcctc  gtggccagg  ttctcacgt  ccttaccaa  ctcaggtga  aatcttgca  5760
ggagccatc  tccctttcc  ctcacttct  tctgctgtt  cctctgaga  accacgtgt  5820
catgtccgt  cccacctcc  gggtcagca  cagttgagc  cttgttctg  gataaatgc  5880
atgaactat  tgagtgaaa  ggtgccttt  gttacatag  tcttggcta  tgctttttt  5940
tttttcttt  ttctgacca  gctacccca  acctcacag  gttcatgct  ctgccttca  6000
aggatcata  ctaggctgc  ggcctgtgg  tgtcaggct  tgctgaggt  aaattgaca  6060
ccctgtcgg  ggctgactg  aatgctgta  cataaatgc  tgttggcct  acatggcct  6120
acctcagaa  aggagcctg  tccaggatt  ctaacccca  tgtcctttc  cggctctgg  6180
caggcacgg  tctgtttgg  ttgggtttt  atcgatgac  gacattcct  cctttgcag  6240
ctcctcctg  ccaggtgac  gaggctgtg  aggttgcta  cgacatggg  tatcgccac  6300
ttgactgcg  ccaggtgta  cagaatgag  aggaggtgg  ggtggccct  caggagaag  6360
tcaaggagc  ggtggtgaa  cgccaggat  tcttcattg  cagcaaggt  ccaccaatc  6420
gtgaggatg  tggggtcca  ttcactccc  gccaggggg  cccagctgc  agtcaggtc  6480
acccttaac  tgatggcgg  tagtgctgg  cgggtggtg  acctgttac  tgtccacct  6540
tgtatctct  tgctgggcc  gtagatgag  gcctggttg  gggttgact  gcccttgta  6600
ggagtgact  cagggacag  gttaagtta  ttgacaaac  gggtttcac  gctggcctt  6660
agttttagc  agaggctgt  gatgtacaa  ggagcccag  ttggagggc  atgctggct  6720
catgtggac  agcttggct  ggaagtaga  ctagagcat  tgtttagca  ctcctgatc  6780
acagccgtg  ctcgtttag  ctctgtgag  tgctcttga  ctgaccacc  cacttgcct  6840
tgggaagtt  ggatccgca  tatgaactg  aaactctcc  gctactcct  gcgtcatgg  6900
tatggggag  ggagagcat  tgtgtcctc  gccttggga  tgtgtggct  ccagccggg  6960
agaggcatt  gcatggcag  gtaacctgt  ccgtttgct  gctccagct  tggtgcacg  7020
tccacgacc  gagcatggt  aaaggggcc  gccagaaga  gctgagcga  ctgcagctg  7080
actacctgg  cctctacct  attcactgg  caactggct  caaggtgag  ggcacacgg  7140
ggctggatc  gagcggttc  ggtgcggtc  tctctttct  ctcagcacc  tataggtgc  7200
tgactcatc  tgtctctgc  gcttggggt  tgcttctgg  ccagcatca  cgtcatcac  7260
taaaacgta  tagaaacca  cttcaggcc  ctctgcact  tctgaagcg  tggtggctc  7320
gatgcagcc  ttggagtct  ggggacacc  ctcttttca  tcagtgcct  cagaactta  7380
aactgacag  aaatatggc  gacaggact  ctgttgtcc  tgttgcaca  ggctgtagg  7440
gaagcctgc  ccgctgagt  tcctctggg  cttacatgt  atgcacgcc  gcgcgcgcg  7500
gcgcacgca  acacacaca  acacacaca  acacacaca  acacacaca  atgagtctg  7560
acctccgtt  catgccagt  tcatttgtg  ggtgacccg  agatctcag  gtcacttct  7620
gtatttctg  gtggtgacc  agatggaaa  gtcactggt  ttatcctcc  ctctgtttt  7680
gcttaccat  gtctcttgg  gcccgaggg  ctagatttt  accctgtgt  ttttatgac  7740
agccagaaa  agagaggca  agtgatagc  ttctaggtc  gagagccac  gagactcac  7800
gtgcctgag  ttccctacc  tgcccacag  cccttctcc  tgtcaggct  gggctcaga  7860
acttggata  gtctgaatc  ccatttgac  ccctcacag  tccagtcat  acagggatt  7920
ccatcgggg  cactttctg  ttccttttc  tcttggcta  cagatatac  tcttaccat  7980
ttccacagt  tgtagtgct  tgagattaa  aagtctgtg  agaagtgtc  ctgatgatt  8040
tgtgtgtgt  cttgttgtt  ctgacagcc  gggcctgac  atttccccc  ggatgcatc  8100
ggaaacgtg  ttcctagtg  caccgattt  gtggacact  ggacggtaa  atgcccctg  8160
ctgagaccc  tgtttattg  tggtaccct  ttattgtgt  caagccagg  gtgagtgat  8220
tgctctgcc  tgtcctgtg  ttagatcat  ccgtctctg  gtctgtctg  taagtctcg  8280
gaaagccag  ccagttttc  tcttggctt  tgaaagata  aagggtctg  ccgcggatg  8340
gagggctca  ctgtaaagt  ctggacaca  acatgcttc  ggttcttgt  ctcttggag  8400
tcattttag  actcagatc  cttttcttt  taggctatg  agcaactag  ggatgaagg  8460
ttggtaaaa  caatcggag  ctccaactt  aaccctctt  agattgaga  gatcttgaa  8520
aaacctggc  taaagtata  gcctgctgt  aaccaggta  gcgtcccca  gggaggatg  8580
tggcatgct  ttttaccag  cctggctct  gcctgtgga  cacagagag  agaagctct  8640
cagggatag  atttgaggc  agtcagcaa  gacgtggct  ctaacataa  ccgtgggta  8700
ctggtgaga  ctgcaggct  ttatctatt  ataatggcc  aggccaggg  aggccttat  8760
ggcttatgg  catagagca  tggcaacaa  attattctt  ctcttaatg  gaaggccat  8820
agctgggaa  tgtggagag  tgttccagc  tatctggga  gcagacatt  ctgtgtggg  8880
agaaaaggg  cattgacca  gtcacatga  tttgtgtcc  ctgccacag  cacccctcc  8940
gcttgtgtt  cagatcgag  gccacccat  cctaactca  gagaagctg  ttgagtact  9000
ccattgcaa  ggcatcgtg  tgactgcat  cagtcccct  ggttctcct  acaggccct  9060
gtgagcttc  gtgggagca  tgttggaga  aagaaataa  caaagggaa  gattggttg  9120
cagagagaa  gcttctgtg  tggctgcag  ccttccgtg  gtcctctgg  cttcctggg  9180
ggttcatgt  tctaggagc  agagatgga  atatattct  ttgcaaagg  tcagcaggt  9240
gatcatgac  cagcttcgg  ctaggagcc  gaccaacca  ccaggagtc  gtgggagga  9300
cagggctag  tggccggct  ccttgagtg  cagtggtga  gattgttga  ttccccatc  9360
ctctgctcc  gggccaagc  tgaggaccc  tctctcctg  aggatccca  gatcaagga  9420
attgcagcc  agtacaata  aactacagc  caggtatgg  tgcttcttg  tacttttga  9480
tgaactcta  actcacagt  gtccctgtc  gtcaggagt  gagggggct  agcctgaag  9540
cctctgtgg  agtgtggtt  ggagtccta  aatgcagtt  aggggcaca  atgtagaaa  9600
tgagagaat  aagtgacac  tggccctgg  acaatagtg  ctgtcccca  cgtctctat  9660
tgcggcaca  gcatcagcc  agcgtttag  gctgttctt  gaagctctt  ccggttact  9720
atagaagag  tcttactgc  tgcggtgtg  gaggtgttc  ctttcttcc  ggggtagtg  9780
gaccaggca  tgacttcct  tggccttgt  acatgcctg  agccactga  ggagcagga  9840
tgtagggtc  gatttgcac  aactcgtgg  tgtcacttg  cgtctcaca  cctctttgc  9900
tgtgcactt  ttgactgag  tggtaacac  gtgtattta  acactccac  cctctgcat  9960
cgcaggtgc  gatccggtt  cccatccaa  ggaacctgg  cgtgatccc  aagtctgtg  10020
caccagcac  tattgctga  aactttaag  taagatccc  gctccaggc  tggctttcc  10080
ccatggcag  tgggtcctg  gggttctcg  cctcccctt  ctttcccag  tgtgtgatt  10140
cgagcaagt  acttgacta  actcaaaac  gtgcctatg  tgagggctg  ggtgagact  10200
aagttcgtg  tgcacacgc  acagcactt  atagccctg  ttccacact  agtgctcag  10260
aaacattgc  gtgctggtg  tgggtccat  gacgcccag  acatacacc  atccactgg  10320
tctgttaag  cctaagcag  catgagcag  ggtgggaat  cttgggcac  aggagtgta  10380
gcatggaga  tgccctacc  ccaccactg  agcagctca  gctacctgg  gagaggcta  10440
ctgggaaag  gctgctcca  gacggtcct  ggaccacat  acaggagcc  ctggcccgt  10500
aaagcaaag  gatgctctg  cgaagtctg  ttcaaagtc  gccccacag  gtccacaat  10560
ggcactaga  tggttctga  gacatagta  gctactcta  tcctacctc  tcctcgtga  10620
cgtgaccat  cataccact  acatgtaac  atgtgggac  agagacatg  cctgctaga  10680
atgggttaa  acctcaccc  ataattcat  tctaaagta  tagggaaga  aacacagcc  10740
ggcggtggt  gcgcacacc  ttaatccca  cacttggga  tcagaggca  gtggatctg  10800
gagtttgag  ccagcctgg  ttgcagagc  agttccagg  cagccaggg  tacacagag  10860
aactgtctt  aaaaagaag  aagaatgtc  gtgaccaat  ttaacccac  gacctagtg  10920
ttcgttttt  tttgtttct  tttttcatc  tactgtgca  tttgcttgt  tctccatgg  10980
tgcagtcac  agagaatgt  gcagagtct  gtcctgcac  ttccgccat  agaatgtgc  11040
aagtggagt  ggttgtcag  gtgcagctc  atttccaag  cctggtgct  cggaaggcc  11100
tctggtcta  ttgtccacc  tgtacccta  cttcttttc  gtattctgt  gtggggtat  11160
caccggaga  gactaagca  acatgagtt  aaacaagta  aaagtcttt  ttagccagc  11220
tgtgactac  ctgggtgtt  gggatccca  gcctttctc  gggtttaag  acacaatca  11280
atcttgggt  tgatacacc  cagttaaca  gaacaatta  ccagaggta  aactgcaga  11340
gccagaagg  gaggctagc  catgtagag  cttttccag  actatggac  ttgatgtga  11400
ttaaaaata  aaacaaaca  aaaaattag  aaggaaagg  catgactgc  cctgaaccg  11460
ggggttggg  tgaggggga  caagtacaa  agccaggaa  ccaaaggta  aaaaggagc  11520
aagtgggta  taagggaac  gtcgggctg  ataggggag  ggctggaga  ctgagtaga  11580
ggtgggtgt  cccgccaca  cctgtaatt  gtagggact  aagggtatt  aacctggag  11640
ccaggtctg  ttagctacc  taaataggc  ccttagacg  ttgccctgg  attgaaatt  11700
aacagcagg  tagccccag  tctggcaca  aacacccca  gactgtaat  catccttca  11760
cttcacctt  gctgggtgt  ttgcttggt  tttgatttg  ctgacggtg  tgtgtacct  11820
ctgagtttt  tgacttgaa  ggtacttcc  tccatcatg  agtcagtgt  ctagggtct  11880
ttacatatt  ctgtattca  tcttttgtc  tcgtggaag  ctttcttgc  ctgtatgtc  11940
aaacctgac  tattttctt  ggccttgtc  cacatggat  cgcgaggca  tgtccttcg  12000
tccccagct  gagtgcctt  ctggggaca  cccagagcc  ttctttcat  acagcgcag  12060
acccagaac  cggattaat  ggtgttcca  ctattgagg  gtctcctct  acacttctg  12120
tgaatggag  agtcaggac  ctcagtaac  tttcccctg  tgcttatca  agtagagcg  12180
ctcaggagc  tgacaggaa  gactgaaca  tgccctctg  ttggaaatc  tggaaggga  12240
aggccattt  agatagggc  acaagcctg  accttctgg  gcataatta  cagtcttct  12300
gaagtccca  gtcctctcc  gccctctgc  ctccaggca  tgagggcca  ctggaactt  12360
ctgctttgt  tctgtttta  tgtgagctt  ttgactttg  ttctttcct  catgtttgt  12420
tgtaaggtc  ttgactttg  gctgagcaa  gaggacatg  ccactctac  cagctacaa  12480
aggaactgg  gggtgtgcg  cttgatgag  tgagttcca  tgtggtgcc  gttctacct  12540
ttctatgtc  ccaaatgtt  agactaaca  gcatctctc  ggccccaga  gcagggtcc  12600
tcccctgca  cccgccctg  tttcacaca  accttgtct  ctaatctat  cagacccgg  12660
ggcactgca  aaagccagg  gagggtggc  gtcaggaga  ctgcctggg  gcacagttg  12720
tccactttg  cttttctga  ctcagatgg  cccaggggc  tctctggta  ccaccttcc  12780
agaagagtt  gcatgtgac  gattgactt  atgacgcta  cgaggagtt  ggtaggaag  12840
ccctggtgc  gggctcagg  tagccccag  tctggcaca  aacaccctg  gactgtaat  12900
ccactcaga  ggctgtaat  ccactcaga  ggctgtaat  ccactcaga  ggcttaatg  12960
cactcgggc  cccagggcc  ttcagcttc  cctctgctg  ttttttgct  ccctctgaa  13020
tggggtttg  actccgaat  cctggggat  agtttgctt  aagaagcag  ctgtgtccc  13080
aatgcctgc  ttgtcttcc  gtcttgatt  tcactcaca  tctcttgct  tcactcgcc  13140
tctgcataa  tcggtgttt  cctggtggt  gccgcaacc  ctacggtct  tataggcag  13200
aaggtttgt  attcgggct  tttacatgt  gccatcaca  agtcctcag  ttctaagta  13260
gctgtaaac  gaactagcc  aggactctg  aacaggacc  tttctgata  tacactaag  13320
acgtttaac  ttttaatgt  aaaatcatc  tttactttg  atctaacgg  caggagaga  13380
gcgaatcac  tgcctgtag  atccatccg  ttcctagag  ctgtagtag  taagtcact  13440
agccctgcg  gttccctgg  actgctgat  ctgacatca  agcttgtgg  gagagcaaa  13500
cctttgtgt  tgctcacct  cttgcacct  ccatgacta  tctagaagc  gctgtgctt  13560
gacagtact  agttgacat  ggttgcagt  ggggttggg  caggggcgg  ctctagtgc  13620
cccagcaaa  ctttcctaa  atgccagcc  tcctgtgga  acacacggc  atactgagc  13680
cttgctgct  gtgtctgag  ccaggatgc  aagaaaggc  gttgcgggg  agcttgagt  13740
atctgagtg  tcagtgaga  ctgcatacc  ggggcctgg  tcatcctca  cctctgggg  13800
gtggaaaga  acgagcagt  cacttttgc  tggattcta  aagagaagc  caacctcag  13860
cgaaaacat  ctcatcttc  gaggagtag  gcaaccttt  ttagtttga  ttgattaag  13920
aagaaatga  ctttcttat  tttgattta  cttcctgct  ttctccaaa  agcaggagc  13980
gtctgggac  tcatggtat  gtctctgat  ttttattgc  gaattaact  gattttttt  14040
taatgtgag  gtgtgtgtg  cacactagt  gtcctttga  tccaacatg  gcgcgcacg  14100
gcacacaca  acacacaca  acacacaca  acacacaca  acacacaca  acacacaca  14160
acacacacg  gttcaggct  tgacactgt  cctgcctag  ttctctagt  ttcttgcca  14220
tttgttccc  ttataagcc  ttggcccta  caaatagac  gtgaacctt  gctccatgc  14280
agcccttgc  ctgttcctg  agtacatcc  cagctgctg  taggtgctc  tttcactcc  14340
gatgtcaca  aggggcctc  cctttcctg  gagtggctg  ctgtttgac  tgcccttca  14400
ggttcagtg  ggtacagct  gtaaaccct  ctactgctt  gttatctct  ttcttttgg  14460
cctgtgttc  ggagctgat  aaatgaact  ggtgtagtg  cacacgcct  taatcccag  14520
acttgggag  tggagtcag  aagacctga  cttcaaggt  atcctcagc  aagcagtgt  14580
tttgaggcc  gccccgcct  accagaccc  gtcttaaaa  acagcagaa  gttgacatg  14640
ggctgtatg  tcctgccag  tcctcagag  tcccacgca  gacttgctg  ccagtgtgc  14700
ccaggctag  gcttagtgc  gcctgtcac  tgatgcagt  cctgacatc  caagacaag  14760
ggagctcag  gcctgagta  ctgtaccta  gatcagaag  ctctaagac  gctcagtcc  14820
cagtgagac  ccgtttctc  gtgttggtg  ctcgttcgt  acagacaga  tctttttcc  14880
tgagagctg  caaggtggt  cagagtgtt  agacatttg  atcaatcct  aggataaac  14940
gagtttatc  aggacccac  cgataggag  gaagcaact  acactaaat  aataagtga  15000
cccaattaa  tttaggaag  ctttaactt  taaattgca  gtattcttt  ctgacagct  15060
tgccaaaca  aaggattac  ccttccacg  agaagtctg  agctgtggt  gacgaatcc  15120
gctcctccc  aagcgactt  acacatgtt  tttctgcct  atctgccct  gcaagtgtc  15180
ctctgcact  ggtggcacc  tgcagacca  atggtgaga  tttgttagt  tgacgtaga  15240
tgtggaggg  agtaccagt  gctgaggag  ttcttcggc  tttcttggt  ttcttccca  15300
ctggaggac  ttaacacga  taccttttc  aaccaaaga  aaagcaaga  ttatagccc  15360
agtcatgcc  ctaacactt  aatttgagt  cttagaact  cagtcctat  ggggtcaga  15420
tttttgcct  aaataaaaa  tgcttttgt  aatttggtg  tcgtctgtt  tgcttttgc  15480
ctgtaatac  gtgcacccc  tctgcccca  acccagcct  agtgccaag  acaggccag  15540
gctgtgaac  aactgagaa  tcgtatcct  gcacgacac  gcagagtgt  agggtggtg  15600
gtagcatcc  ggtgacatg  tgagctc  15627



<210> 3745
<211> 315
<212> PRT
<213> Rattus norvegicus
<308> AAA40721
<400> 3745

Ala Ser His Leu Glu Leu Asn Asn Gly Thr Lys Met Pro Thr Leu Gly 
  1               5                  10                  15
Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val Lys 
             20                  25                  30
Val Ala Ile Asp Met Gly Tyr Arg His Ile Asp Cys Ala Gln Val Tyr 
         35                  40                  45
Gln Asn Glu Lys Glu Val Gly Val Ala Leu Gln Glu Lys Leu Lys Glu 
     50                  55                  60
Gln Val Val Lys Arg Gln Asp Leu Phe Ile Val Ser Lys Leu Trp Cys 
 65                  70                  75                  80
Thr Phe His Asp Gln Ser Met Val Lys Gly Ala Cys Gln Lys Thr Leu 
                 85                  90                  95
Ser Asp Leu Gln Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro 
             100                105                110
Thr Gly Phe Lys Pro Gly Pro Asp Tyr Phe Pro Leu Asp Ala Ser Gly 
         115                120                125
Asn Val Ile Pro Ser Asp Thr Asp Phe Val Asp Thr Trp Thr Ala Met 
     130                135                140
Glu Gln Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Val Ser Asn 
 145                150                155                160
Phe Asn Pro Leu Gln Ile Glu Arg Ile Leu Asn Lys Pro Gly Leu Lys 
                 165                170                175
Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr Gln 
             180                185                190
Glu Lys Leu Ile Glu Tyr Cys His Cys Lys Gly Ile Val Val Thr Ala 
         195                200                205
Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu Asp 
     210                215                220
Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Glu Ile Ala Ala Lys Tyr 
 225                230                235                240
Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Ile Gln Arg Asn 
                 245                250                255
Leu Val Val Ile Pro Lys Ser Val Thr Pro Ala Arg Ile Ala Glu Asn 
             260                265                270
Phe Lys Val Phe Asp Phe Glu Leu Ser Asn Glu Asp Met Ala Thr Leu 
         275                280                285
Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Met Ser Cys Ala 
     290                295                300
Lys His Lys Asp Tyr Pro Phe His Ala Glu Val 
 305                310                315



<210> 3746
<211> 1367
<212> DNA
<213> Homo sapiens
<308> NM_001628
<400> 3746

gaaggccgc  ccgtactgg  cgggggtct  gggagcgca  cagccatgg  aagccgtct  60
ctgctcaac  acggcgcca  gatgcccat  ctggggttg  gtacctgga  gtcccctcc  120
gggcaggtg  ctgaggccg  gaaggtggc  attgacgtc  ggtaccgcc  catcgactg  180
gcccatgtg  accagaatg  gaatgaggt  ggggtggcc  ttcaggaga  gctcaggga  240
caggtggtg  agcgtgagg  gctcttcat  gtcagcaag  tgtggtgca  gtaccatga  300
aagggcctg  tgaaaggag  ctgccagaa  acactcagc  acctgaagc  ggactacct  360
gacctctac  ttattcact  gccgactgg  tttaagcct  ggaaggaat  tttcccatt  420
gatgagtcg  gcaatgtgg  tcccagtga  accaacatt  tggacacgt  ggcggccat  480
gaagagctg  tggatgaag  gctggtgaa  gctattggc  tctccaact  caaccatct  540
caggtggag  tgatcttaa  caaacctgg  ttgaagtat  agcctgcag  taaccagat  600
gagtgccac  catatctca  tcaggagaa  ttaatccag  actgccagt  caaaggcat  660
gtggtgacc  cctacagcc  cctcggctc  cctgacagg  cctgggcca  gcccgagga  720
ccttctctc  tggaggatc  caggatcaa  gcgatcgca  ccaagcaca  taaaactac  780
gcccaggtc  tgatccggt  ccccatgca  aggaacttg  tggtgatcc  caagtctgt  840
acaccagaa  gcattgctg  gaactttaa  gtctttgac  ttgaactga  cagccagga  900
atgaccacc  tactcagct  caacaggaa  tggagggtc  gtgccttgt  gagctgtac  960
tcccacaag  attacccct  ccatgaaga  ttttgaagc  gtggttgcc  gctcgtccc  1020
aagtgacct  tacctgtgt  tcttgcctc  tttttttcc  tgcaaatgt  gtatggcct  1080
tgtcactca  cagtgggac  gcaacctgt  gagtggcca  cgagggcgt  tctagcttg  1140
tgttggatc  caagagccc  gtcagtaga  tagaagtct  ttccagttt  ctttgccct  1200
ctttctacc  tgctgggga  agtacaacc  gaataccct  ttctgacca  agagaagca  1260
aatctacca  gtcaaaata  tgccactaa  ggttgagtt  tgactgctt  gaactggaa  1320
cctttcagc  agacttctc  ttgcctcaa  taaaaagtg  ttttgtg  1367



<210> 3747
<211> 315
<212> PRT
<213> Homo sapiens
<308> P15121
<400> 3747

Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu Gly 
  1               5                  10                  15
Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val Lys 
             20                  25                  30
Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val Tyr 
         35                  40                  45
Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg Glu 
     50                  55                  60
Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Leu Trp Cys 
 65                  70                  75                  80
Thr Tyr His Glu Lys Gly Leu Val Lys Gly Ala Cys Gln Lys Thr Leu 
                 85                  90                  95
Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro 
             100                105                110
Thr Gly Phe Lys Pro Gly Lys Glu Phe Phe Pro Leu Asp Glu Ser Gly 
         115                120                125
Asn Val Val Pro Ser Asp Thr Asn Ile Leu Asp Thr Trp Ala Ala Met 
     130                135                140
Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser Asn 
 145                150                155                160
Phe Asn His Leu Gln Val Glu Met Ile Leu Asn Lys Pro Gly Leu Lys 
                 165                170                175
Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr Gln 
             180                185                190
Glu Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Val Val Thr Ala 
         195                200                205
Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu Asp 
     210                215                220
Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Ala Ile Ala Ala Lys His 
 225                230                235                240
Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Met Gln Arg Asn 
                 245                250                255
Leu Val Val Ile Pro Lys Ser Val Thr Pro Glu Arg Ile Ala Glu Asn 
             260                265                270
Phe Lys Val Phe Asp Phe Glu Leu Ser Ser Gln Asp Met Thr Thr Leu 
         275                280                285
Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Leu Ser Cys Thr 
     290                295                300
Ser His Lys Asp Tyr Pro Phe His Glu Glu Phe 
 305                310                315



<210> 3748
<211> 15627
<212> DNA
<213> Rattus norvegicus
<308> M60322
<400> 3748

ggatccagg  agttcaaat  gcagagaag  ctctatgcc  agagggatt  cacagagga  60
aagtggcgg  tgtcaggtc  cctgttatc  tacacaaac  taatcccca  cactacact  120
aaattcaaa  tctactatt  agagaaaaa  tacacaaga  cttccacat  ccaacagct  180
tggggtttt  ttttgttaa  aaaatccaa  tggaaaata  ctgttcttt  taaattttc  240
cagggatgg  agtggaaga  tgccacctt  taggagggc  ccaactgga  aatcaccag  300
atggcactt  gagaggtgg  gttcctgac  cattactct  cagatgcag  tgtctgtgt  360
gcataatca  gggggcgac  gaagcatga  ccagcagaa  gagactcag  caaaacaga  420
catcacgca  aggggtgtt  gaagagtgc  aaatttccg  cattgttct  ggggcaact  480
cgattattt  agggaaagt  tttgttttt  tacccaata  caactgatt  atttatttt  540
tgtcccctt  acttggaat  attgctgta  gaaaacgga  ttttcctag  atgggattc  600
gcctgttca  ttttcttcc  gagagagtt  ggtcaactt  ctatactgg  acctgcccg  660
tcaacagtt  tactttccc  aatcattta  gtgtgatcc  gagatcaag  ttatgaggg  720
ttatagcta  cggttgctg  gtttcgcat  aaggcttgt  gaaccagat  gagcatgtt  780
agacactgg  aatggtaga  agctactac  agcgggcat  ttgtagtat  ttgcaaagc  840
ggttacaat  atttcaatt  agggggctg  gggaggggg  ggcttaaat  cacctgaag  900
ttaactttt  acataagac  aaaaaaaaa  aaaaaaaaa  aaaaaaagc  cttaagtac  960
cctgacgcc  atctgctcc  tcagtttca  aacaagatg  gcaggattc  agaagagta  1020
tattctgag  ttagaaaaa  acacaagcg  ctttttctg  cctctaaaa  gaaaccaaa  1080
ccttttccc  gtctcctta  ctctagtct  ccggttatt  tcagagcgt  tagtctggt  1140
cttcaacag  aggcaaaca  tctgccacg  ggggcgcag  gcagctgga  aattccgtg  1200
ctctaggac  tagggaaag  agcatcctc  ctgaccctt  aaggaccac  gaagagacc  1260
atcagaagg  gccgtctct  agccgtgcg  caatcgcag  cgtcctttc  gcaggctgt  1320
ggggctatt  aaaggtgcg  gccggagcc  gcgctgcac  cttgcgggt  gttgtgcgt  1380
acttgcagc  atcatggct  gccatctgg  actcaacaa  ggcaccaag  tgcccaccc  1440
gggtctggg  acctggaag  taggtgctc  tcagggcgt  gcccgccac  cgctgggtg  1500
ccctgagcg  cctgcgcgg  gcggggctc  ggtggttgg  gcctgtggg  gcatccggc  1560
gcggccccg  gtgtggggc  ctgggcgag  attgcgcga  tccgcgtgg  tgccccagg  1620
ggagacaca  ccacggggg  gagaggaac  gaagcaggg  tctagattt  tcatctggc  1680
ccccaaact  acgagtgag  tgacctcac  tggagcaga  gttgccctc  cgggaatga  1740
ccacttggc  gataggcct  agataatta  attaggagg  gagagtttg  agtgaacca  1800
cctgtttct  ttttcctta  atcgctgag  gcagctctt  acgggtgcg  aactcctct  1860
gaattaatc  ggtttccgc  ttgctgggt  ccaccctcc  caaacccca  cacaacaca  1920
caggcttga  aagacggcc  gatacgtta  agtgaaata  aaaaagaaa  aaccgataa  1980
taaaaacta  aaattataa  tgatttgat  atttgaaaa  taaggaacc  gttttggtg  2040
tattgctga  gcagaaaaa  ccagctctt  agctactgc  gtgacctgg  tctttaaga  2100
cctggagta  gggtgaacc  gggctgtat  taagcactt  gacacagtg  aggaaagag  2160
aaatcatgc  gggttgagt  cagatggtt  gaaactgga  agtctgttt  tacccagac  2220
acagttaaa  tgggtaatg  atatggtga  taagaaaca  gtcatagac  tgtctttct  2280
tgaatgtgt  tctaagcca  tagattagc  agtgcggct  tcgtttcct  ccaaagggt  2340
cttggtgac  gtaaagatg  gattgaatg  gaaccatca  accagatta  attctatgc  2400
ttggaagga  aagaaagat  gtttccttg  tgtaataaa  acagcacag  aaaggcaca  2460
ataactaca  tggttttgt  atacacgac  ctcaacatg  gtgggatgc  gatacttta  2520
ttctgtccc  tttctctaa  aaccaagct  ataacttta  aaaagcatt  tgagatcag  2580
tctcgggta  acacgagta  acattcata  gccggtggc  agagcggat  caacagccc  2640
agagagctg  gtgtttgtt  aaaattaca  acattttaa  gtatagatc  ttctgccgc  2700
ttcacagat  ttcctgtca  ttcccgcag  gcctggctt  tagaatgga  ccagaagtc  2760
tgttgagtt  gggcagggt  aagaaaatg  ctgcctgtg  ctgggggca  ggggaggtt  2820
gtgcagaga  cgtggaggg  cgaagggtg  cagtgagag  caggaggac  gccgagact  2880
ccagatttc  ttttttttt  ttttttttt  tttggttct  tttttttcg  agctgggga  2940
cgaacccag  gccttgcgc  tcctaggca  gcgctctac  actgagcta  atccccagc  3000
cccagattt  cctttttaa  aaaagaata  caacttaat  ctttccttg  acatgtgtg  3060
cgttccttc  tagatgaca  agtatatca  agtcactgt  atggtcaca  agggtgtgt  3120
ggtgcggtc  cttgttctg  aacttcatc  gtggccacc  ggtacctca  agaccacag  3180
gggactctg  cagggtatg  tccactctt  ccttgaggg  atctgtttc  cctgggagg  3240
gaggatttg  ggcagttgg  agacactct  acttgcatg  actttcttc  tggccaact  3300
gcctgccct  tggaccccc  aaatgcatg  taaatatac  atattacat  aaaatactg  3360
tttaagttt  gtgtggtca  gaggccttt  aggcagagc  ggcctgata  agaccacca  3420
gccctttta  tgataatgt  ttgacctag  tgaaaatct  tgaaggaca  ggccattgt  3480
tcttccaca  ataggctag  aattgctgc  aggaatgta  ggacagctg  gttctcaga  3540
tattttcca  ttaatgccc  ctgtgcctc  aaaccatga  tctcttgag  tgaactttt  3600
ttttctttt  ggcctaatt  tatcccaat  ggattctgg  atctcagat  aaactacta  3660
atatgtgct  acgccctgt  ttccctttc  cagggtcac  tggcattct  aagctgtga  3720
atattttct  tgcttgctt  ttgagtgtg  tttttgcct  tctgggata  tagtacttg  3780
ccttagaag  aaactgtgc  agggtcctc  tgccatttc  tgagttaaa  caagtgtcc  3840
ctgacagtc  tagagcctg  ggtcaggga  aaatgctgt  ctcattgaa  taggagttt  3900
gttttctgg  ggcctgcca  tgaccaggc  acactcctc  acctttcca  atttaagat  3960
aaaaaaaaa  atcaaatat  tcttgtcta  gcagggccg  tcctggagc  acatctctg  4020
ggagtggag  tgtgtctta  aatccggac  gctttattg  ccgataaca  tagaacacg  4080
tttattagt  ttgttgcta  actaggctg  gggctttca  tgttctcag  ctggggaaa  4140
ggccattct  gagggttca  tcttcatct  ttggaatca  cgttaaagt  cttgaactg  4200
gaggcgagg  tataccatc  aaacaaaca  gtgaggctg  tttctctca  tccagcagt  4260
ggaagtgct  tttgtggcg  ctgggtagg  catgaaagg  ggcacattg  gatcattct  4320
ggggttttc  gtcagagac  tggggaggt  gtacattta  gcctgttta  taagccacc  4380
gggttctgg  ctgtgtggg  aggaagccc  tggaagcag  gttctttct  ctgacctgc  4440
ctttgagcc  ttatctgtc  ttgtctttc  gtgaaaaca  cacacagaa  ttttttcct  4500
tgggttttg  tttggcgtc  gatgttcca  gacgtcgct  agtgtagtg  tggtctgcg  4560
cagtgtagt  tcagtgcat  ctgcactct  gcttggagg  acagaaaag  caggttaac  4620
tcacgcaga  ggcaagcag  aaagttggg  taggggtgg  gcctcattg  aatagccat  4680
acagtcact  gattcacgg  ttggattcc  ttctgggtt  taaattagg  taccagaat  4740
gagacgttt  agaccccat  ctctcaagg  gttgcgagc  ctcattctc  cagcaaagg  4800
ctccaggat  attcctcag  gggtgggcg  aggtcctga  atggagtac  atagccccg  4860
tcggctcac  ccatgttcc  gcttctgtg  gagtggctg  ggcaaatgt  gggtggctt  4920
gcccagcct  gaccttgtg  ccagcgctc  atccaaagc  aagctctgc  aggctctaa  4980
taggcttcc  acaaggcga  catgagagt  agcacaagg  ccctggatc  tgctataaa  5040
tcatcgtat  tccgaggca  gagaaacac  cacacactc  ccaggcccc  cttgtgtgg  5100
ctttctcaa  cagggattt  ccttttccc  cacagctag  accagccat  gctgtgtct  5160
gctgcccca  agggccctg  ccgggagag  ctttccctg  ataggccga  atagttcct  5220
taaccacag  aggaacctg  ggagaagct  agctacagg  gcactcttg  gtcctccag  5280
gaaatgaga  gggggccaa  cagtctaaa  gcacgtagt  aaggtaact  agtcctaag  5340
acgctgtgg  ccttccacc  ggcaggtcc  tccccactg  gtgaggagc  aagaccact  5400
cccacaggt  ctggggatg  gcttcttct  ctgtttgct  ttttatccc  tgactgttt  5460
gttcacaag  ctccagaca  aacagacgt  ggcggctgc  gatggcctt  gggagtttt  5520
tttttcatc  gattttgcc  cagctcgcc  gaggaatgt  ctgtgttcg  tcagcggcg  5580
ccagcgcag  gtcttgttt  gctctctag  cttggcaag  gcagcctgg  gatgggtaa  5640
agtgctgtg  agtccgggg  ctggtgaag  tcaggacta  gcaggctcc  cctcttctt  5700
ctcctcctc  gtggccagg  ttctcacgt  ccttaccaa  ctcaggtga  aatcttgca  5760
ggagccatc  tccctttcc  ctcacttct  tctgctgtt  cctctgaga  accacgtgt  5820
catgtccgt  cccacctcc  gggtcagca  cagttgagc  cttgttctg  gataaatgc  5880
atgaactat  tgagtgaaa  ggtgccttt  gttacatag  tcttggcta  tgctttttt  5940
tttttcttt  ttctgacca  gctacccca  acctcacag  gttcatgct  ctgccttca  6000
aggatcata  ctaggctgc  ggcctgtgg  tgtcaggct  tgctgaggt  aaattgaca  6060
ccctgtcgg  ggctgactg  aatgctgta  cataaatgc  tgttggcct  acatggcct  6120
acctcagaa  aggagcctg  tccaggatt  ctaacccca  tgtcctttc  cggctctgg  6180
caggcacgg  tctgtttgg  ttgggtttt  atcgatgac  gacattcct  cctttgcag  6240
ctcctcctg  ccaggtgac  gaggctgtg  aggttgcta  cgacatggg  tatcgccac  6300
ttgactgcg  ccaggtgta  cagaatgag  aggaggtgg  ggtggccct  caggagaag  6360
tcaaggagc  ggtggtgaa  cgccaggat  tcttcattg  cagcaaggt  ccaccaatc  6420
gtgaggatg  tggggtcca  ttcactccc  gccaggggg  cccagctgc  agtcaggtc  6480
acccttaac  tgatggcgg  tagtgctgg  cgggtggtg  acctgttac  tgtccacct  6540
tgtatctct  tgctgggcc  gtagatgag  gcctggttg  gggttgact  gcccttgta  6600
ggagtgact  cagggacag  gttaagtta  ttgacaaac  gggtttcac  gctggcctt  6660
agttttagc  agaggctgt  gatgtacaa  ggagcccag  ttggagggc  atgctggct  6720
catgtggac  agcttggct  ggaagtaga  ctagagcat  tgtttagca  ctcctgatc  6780
acagccgtg  ctcgtttag  ctctgtgag  tgctcttga  ctgaccacc  cacttgcct  6840
tgggaagtt  ggatccgca  tatgaactg  aaactctcc  gctactcct  gcgtcatgg  6900
tatggggag  ggagagcat  tgtgtcctc  gccttggga  tgtgtggct  ccagccggg  6960
agaggcatt  gcatggcag  gtaacctgt  ccgtttgct  gctccagct  tggtgcacg  7020
tccacgacc  gagcatggt  aaaggggcc  gccagaaga  gctgagcga  ctgcagctg  7080
actacctgg  cctctacct  attcactgg  caactggct  caaggtgag  ggcacacgg  7140
ggctggatc  gagcggttc  ggtgcggtc  tctctttct  ctcagcacc  tataggtgc  7200
tgactcatc  tgtctctgc  gcttggggt  tgcttctgg  ccagcatca  cgtcatcac  7260
taaaacgta  tagaaacca  cttcaggcc  ctctgcact  tctgaagcg  tggtggctc  7320
gatgcagcc  ttggagtct  ggggacacc  ctcttttca  tcagtgcct  cagaactta  7380
aactgacag  aaatatggc  gacaggact  ctgttgtcc  tgttgcaca  ggctgtagg  7440
gaagcctgc  ccgctgagt  tcctctggg  cttacatgt  atgcacgcc  gcgcgcgcg  7500
gcgcacgca  acacacaca  acacacaca  acacacaca  acacacaca  atgagtctg  7560
acctccgtt  catgccagt  tcatttgtg  ggtgacccg  agatctcag  gtcacttct  7620
gtatttctg  gtggtgacc  agatggaaa  gtcactggt  ttatcctcc  ctctgtttt  7680
gcttaccat  gtctcttgg  gcccgaggg  ctagatttt  accctgtgt  ttttatgac  7740
agccagaaa  agagaggca  agtgatagc  ttctaggtc  gagagccac  gagactcac  7800
gtgcctgag  ttccctacc  tgcccacag  cccttctcc  tgtcaggct  gggctcaga  7860
acttggata  gtctgaatc  ccatttgac  ccctcacag  tccagtcat  acagggatt  7920
ccatcgggg  cactttctg  ttccttttc  tcttggcta  cagatatac  tcttaccat  7980
ttccacagt  tgtagtgct  tgagattaa  aagtctgtg  agaagtgtc  ctgatgatt  8040
tgtgtgtgt  cttgttgtt  ctgacagcc  gggcctgac  atttccccc  ggatgcatc  8100
ggaaacgtg  ttcctagtg  caccgattt  gtggacact  ggacggtaa  atgcccctg  8160
ctgagaccc  tgtttattg  tggtaccct  ttattgtgt  caagccagg  gtgagtgat  8220
tgctctgcc  tgtcctgtg  ttagatcat  ccgtctctg  gtctgtctg  taagtctcg  8280
gaaagccag  ccagttttc  tcttggctt  tgaaagata  aagggtctg  ccgcggatg  8340
gagggctca  ctgtaaagt  ctggacaca  acatgcttc  ggttcttgt  ctcttggag  8400
tcattttag  actcagatc  cttttcttt  taggctatg  agcaactag  ggatgaagg  8460
ttggtaaaa  caatcggag  ctccaactt  aaccctctt  agattgaga  gatcttgaa  8520
aaacctggc  taaagtata  gcctgctgt  aaccaggta  gcgtcccca  gggaggatg  8580
tggcatgct  ttttaccag  cctggctct  gcctgtgga  cacagagag  agaagctct  8640
cagggatag  atttgaggc  agtcagcaa  gacgtggct  ctaacataa  ccgtgggta  8700
ctggtgaga  ctgcaggct  ttatctatt  ataatggcc  aggccaggg  aggccttat  8760
ggcttatgg  catagagca  tggcaacaa  attattctt  ctcttaatg  gaaggccat  8820
agctgggaa  tgtggagag  tgttccagc  tatctggga  gcagacatt  ctgtgtggg  8880
agaaaaggg  cattgacca  gtcacatga  tttgtgtcc  ctgccacag  cacccctcc  8940
gcttgtgtt  cagatcgag  gccacccat  cctaactca  gagaagctg  ttgagtact  9000
ccattgcaa  ggcatcgtg  tgactgcat  cagtcccct  ggttctcct  acaggccct  9060
gtgagcttc  gtgggagca  tgttggaga  aagaaataa  caaagggaa  gattggttg  9120
cagagagaa  gcttctgtg  tggctgcag  ccttccgtg  gtcctctgg  cttcctggg  9180
ggttcatgt  tctaggagc  agagatgga  atatattct  ttgcaaagg  tcagcaggt  9240
gatcatgac  cagcttcgg  ctaggagcc  gaccaacca  ccaggagtc  gtgggagga  9300
cagggctag  tggccggct  ccttgagtg  cagtggtga  gattgttga  ttccccatc  9360
ctctgctcc  gggccaagc  tgaggaccc  tctctcctg  aggatccca  gatcaagga  9420
attgcagcc  agtacaata  aactacagc  caggtatgg  tgcttcttg  tacttttga  9480
tgaactcta  actcacagt  gtccctgtc  gtcaggagt  gagggggct  agcctgaag  9540
cctctgtgg  agtgtggtt  ggagtccta  aatgcagtt  aggggcaca  atgtagaaa  9600
tgagagaat  aagtgacac  tggccctgg  acaatagtg  ctgtcccca  cgtctctat  9660
tgcggcaca  gcatcagcc  agcgtttag  gctgttctt  gaagctctt  ccggttact  9720
atagaagag  tcttactgc  tgcggtgtg  gaggtgttc  ctttcttcc  ggggtagtg  9780
gaccaggca  tgacttcct  tggccttgt  acatgcctg  agccactga  ggagcagga  9840
tgtagggtc  gatttgcac  aactcgtgg  tgtcacttg  cgtctcaca  cctctttgc  9900
tgtgcactt  ttgactgag  tggtaacac  gtgtattta  acactccac  cctctgcat  9960
cgcaggtgc  gatccggtt  cccatccaa  ggaacctgg  cgtgatccc  aagtctgtg  10020
caccagcac  tattgctga  aactttaag  taagatccc  gctccaggc  tggctttcc  10080
ccatggcag  tgggtcctg  gggttctcg  cctcccctt  ctttcccag  tgtgtgatt  10140
cgagcaagt  acttgacta  actcaaaac  gtgcctatg  tgagggctg  ggtgagact  10200
aagttcgtg  tgcacacgc  acagcactt  atagccctg  ttccacact  agtgctcag  10260
aaacattgc  gtgctggtg  tgggtccat  gacgcccag  acatacacc  atccactgg  10320
tctgttaag  cctaagcag  catgagcag  ggtgggaat  cttgggcac  aggagtgta  10380
gcatggaga  tgccctacc  ccaccactg  agcagctca  gctacctgg  gagaggcta  10440
ctgggaaag  gctgctcca  gacggtcct  ggaccacat  acaggagcc  ctggcccgt  10500
aaagcaaag  gatgctctg  cgaagtctg  ttcaaagtc  gccccacag  gtccacaat  10560
ggcactaga  tggttctga  gacatagta  gctactcta  tcctacctc  tcctcgtga  10620
cgtgaccat  cataccact  acatgtaac  atgtgggac  agagacatg  cctgctaga  10680
atgggttaa  acctcaccc  ataattcat  tctaaagta  tagggaaga  aacacagcc  10740
ggcggtggt  gcgcacacc  ttaatccca  cacttggga  tcagaggca  gtggatctg  10800
gagtttgag  ccagcctgg  ttgcagagc  agttccagg  cagccaggg  tacacagag  10860
aactgtctt  aaaaagaag  aagaatgtc  gtgaccaat  ttaacccac  gacctagtg  10920
ttcgttttt  tttgtttct  tttttcatc  tactgtgca  tttgcttgt  tctccatgg  10980
tgcagtcac  agagaatgt  gcagagtct  gtcctgcac  ttccgccat  agaatgtgc  11040
aagtggagt  ggttgtcag  gtgcagctc  atttccaag  cctggtgct  cggaaggcc  11100
tctggtcta  ttgtccacc  tgtacccta  cttcttttc  gtattctgt  gtggggtat  11160
caccggaga  gactaagca  acatgagtt  aaacaagta  aaagtcttt  ttagccagc  11220
tgtgactac  ctgggtgtt  gggatccca  gcctttctc  gggtttaag  acacaatca  11280
atcttgggt  tgatacacc  cagttaaca  gaacaatta  ccagaggta  aactgcaga  11340
gccagaagg  gaggctagc  catgtagag  cttttccag  actatggac  ttgatgtga  11400
ttaaaaata  aaacaaaca  aaaaattag  aaggaaagg  catgactgc  cctgaaccg  11460
ggggttggg  tgaggggga  caagtacaa  agccaggaa  ccaaaggta  aaaaggagc  11520
aagtgggta  taagggaac  gtcgggctg  ataggggag  ggctggaga  ctgagtaga  11580
ggtgggtgt  cccgccaca  cctgtaatt  gtagggact  aagggtatt  aacctggag  11640
ccaggtctg  ttagctacc  taaataggc  ccttagacg  ttgccctgg  attgaaatt  11700
aacagcagg  tagccccag  tctggcaca  aacacccca  gactgtaat  catccttca  11760
cttcacctt  gctgggtgt  ttgcttggt  tttgatttg  ctgacggtg  tgtgtacct  11820
ctgagtttt  tgacttgaa  ggtacttcc  tccatcatg  agtcagtgt  ctagggtct  11880
ttacatatt  ctgtattca  tcttttgtc  tcgtggaag  ctttcttgc  ctgtatgtc  11940
aaacctgac  tattttctt  ggccttgtc  cacatggat  cgcgaggca  tgtccttcg  12000
tccccagct  gagtgcctt  ctggggaca  cccagagcc  ttctttcat  acagcgcag  12060
acccagaac  cggattaat  ggtgttcca  ctattgagg  gtctcctct  acacttctg  12120
tgaatggag  agtcaggac  ctcagtaac  tttcccctg  tgcttatca  agtagagcg  12180
ctcaggagc  tgacaggaa  gactgaaca  tgccctctg  ttggaaatc  tggaaggga  12240
aggccattt  agatagggc  acaagcctg  accttctgg  gcataatta  cagtcttct  12300
gaagtccca  gtcctctcc  gccctctgc  ctccaggca  tgagggcca  ctggaactt  12360
ctgctttgt  tctgtttta  tgtgagctt  ttgactttg  ttctttcct  catgtttgt  12420
tgtaaggtc  ttgactttg  gctgagcaa  gaggacatg  ccactctac  cagctacaa  12480
aggaactgg  gggtgtgcg  cttgatgag  tgagttcca  tgtggtgcc  gttctacct  12540
ttctatgtc  ccaaatgtt  agactaaca  gcatctctc  ggccccaga  gcagggtcc  12600
tcccctgca  cccgccctg  tttcacaca  accttgtct  ctaatctat  cagacccgg  12660
ggcactgca  aaagccagg  gagggtggc  gtcaggaga  ctgcctggg  gcacagttg  12720
tccactttg  cttttctga  ctcagatgg  cccaggggc  tctctggta  ccaccttcc  12780
agaagagtt  gcatgtgac  gattgactt  atgacgcta  cgaggagtt  ggtaggaag  12840
ccctggtgc  gggctcagg  tagccccag  tctggcaca  aacaccctg  gactgtaat  12900
ccactcaga  ggctgtaat  ccactcaga  ggctgtaat  ccactcaga  ggcttaatg  12960
cactcgggc  cccagggcc  ttcagcttc  cctctgctg  ttttttgct  ccctctgaa  13020
tggggtttg  actccgaat  cctggggat  agtttgctt  aagaagcag  ctgtgtccc  13080
aatgcctgc  ttgtcttcc  gtcttgatt  tcactcaca  tctcttgct  tcactcgcc  13140
tctgcataa  tcggtgttt  cctggtggt  gccgcaacc  ctacggtct  tataggcag  13200
aaggtttgt  attcgggct  tttacatgt  gccatcaca  agtcctcag  ttctaagta  13260
gctgtaaac  gaactagcc  aggactctg  aacaggacc  tttctgata  tacactaag  13320
acgtttaac  ttttaatgt  aaaatcatc  tttactttg  atctaacgg  caggagaga  13380
gcgaatcac  tgcctgtag  atccatccg  ttcctagag  ctgtagtag  taagtcact  13440
agccctgcg  gttccctgg  actgctgat  ctgacatca  agcttgtgg  gagagcaaa  13500
cctttgtgt  tgctcacct  cttgcacct  ccatgacta  tctagaagc  gctgtgctt  13560
gacagtact  agttgacat  ggttgcagt  ggggttggg  caggggcgg  ctctagtgc  13620
cccagcaaa  ctttcctaa  atgccagcc  tcctgtgga  acacacggc  atactgagc  13680
cttgctgct  gtgtctgag  ccaggatgc  aagaaaggc  gttgcgggg  agcttgagt  13740
atctgagtg  tcagtgaga  ctgcatacc  ggggcctgg  tcatcctca  cctctgggg  13800
gtggaaaga  acgagcagt  cacttttgc  tggattcta  aagagaagc  caacctcag  13860
cgaaaacat  ctcatcttc  gaggagtag  gcaaccttt  ttagtttga  ttgattaag  13920
aagaaatga  ctttcttat  tttgattta  cttcctgct  ttctccaaa  agcaggagc  13980
gtctgggac  tcatggtat  gtctctgat  ttttattgc  gaattaact  gattttttt  14040
taatgtgag  gtgtgtgtg  cacactagt  gtcctttga  tccaacatg  gcgcgcacg  14100
gcacacaca  acacacaca  acacacaca  acacacaca  acacacaca  acacacaca  14160
acacacacg  gttcaggct  tgacactgt  cctgcctag  ttctctagt  ttcttgcca  14220
tttgttccc  ttataagcc  ttggcccta  caaatagac  gtgaacctt  gctccatgc  14280
agcccttgc  ctgttcctg  agtacatcc  cagctgctg  taggtgctc  tttcactcc  14340
gatgtcaca  aggggcctc  cctttcctg  gagtggctg  ctgtttgac  tgcccttca  14400
ggttcagtg  ggtacagct  gtaaaccct  ctactgctt  gttatctct  ttcttttgg  14460
cctgtgttc  ggagctgat  aaatgaact  ggtgtagtg  cacacgcct  taatcccag  14520
acttgggag  tggagtcag  aagacctga  cttcaaggt  atcctcagc  aagcagtgt  14580
tttgaggcc  gccccgcct  accagaccc  gtcttaaaa  acagcagaa  gttgacatg  14640
ggctgtatg  tcctgccag  tcctcagag  tcccacgca  gacttgctg  ccagtgtgc  14700
ccaggctag  gcttagtgc  gcctgtcac  tgatgcagt  cctgacatc  caagacaag  14760
ggagctcag  gcctgagta  ctgtaccta  gatcagaag  ctctaagac  gctcagtcc  14820
cagtgagac  ccgtttctc  gtgttggtg  ctcgttcgt  acagacaga  tctttttcc  14880
tgagagctg  caaggtggt  cagagtgtt  agacatttg  atcaatcct  aggataaac  14940
gagtttatc  aggacccac  cgataggag  gaagcaact  acactaaat  aataagtga  15000
cccaattaa  tttaggaag  ctttaactt  taaattgca  gtattcttt  ctgacagct  15060
tgccaaaca  aaggattac  ccttccacg  agaagtctg  agctgtggt  gacgaatcc  15120
gctcctccc  aagcgactt  acacatgtt  tttctgcct  atctgccct  gcaagtgtc  15180
ctctgcact  ggtggcacc  tgcagacca  atggtgaga  tttgttagt  tgacgtaga  15240
tgtggaggg  agtaccagt  gctgaggag  ttcttcggc  tttcttggt  ttcttccca  15300
ctggaggac  ttaacacga  taccttttc  aaccaaaga  aaagcaaga  ttatagccc  15360
agtcatgcc  ctaacactt  aatttgagt  cttagaact  cagtcctat  ggggtcaga  15420
tttttgcct  aaataaaaa  tgcttttgt  aatttggtg  tcgtctgtt  tgcttttgc  15480
ctgtaatac  gtgcacccc  tctgcccca  acccagcct  agtgccaag  acaggccag  15540
gctgtgaac  aactgagaa  tcgtatcct  gcacgacac  gcagagtgt  agggtggtg  15600
gtagcatcc  ggtgacatg  tgagctc  15627



<210> 3749
<211> 315
<212> PRT
<213> Rattus norvegicus
<308> AAA40721
<400> 3749

Ala Ser His Leu Glu Leu Asn Asn Gly Thr Lys Met Pro Thr Leu Gly 
  1               5                  10                  15
Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val Lys 
             20                  25                  30
Val Ala Ile Asp Met Gly Tyr Arg His Ile Asp Cys Ala Gln Val Tyr 
         35                  40                  45
Gln Asn Glu Lys Glu Val Gly Val Ala Leu Gln Glu Lys Leu Lys Glu 
     50                  55                  60
Gln Val Val Lys Arg Gln Asp Leu Phe Ile Val Ser Lys Leu Trp Cys 
 65                  70                  75                  80
Thr Phe His Asp Gln Ser Met Val Lys Gly Ala Cys Gln Lys Thr Leu 
                 85                  90                  95
Ser Asp Leu Gln Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro 
             100                105                110
Thr Gly Phe Lys Pro Gly Pro Asp Tyr Phe Pro Leu Asp Ala Ser Gly 
         115                120                125
Asn Val Ile Pro Ser Asp Thr Asp Phe Val Asp Thr Trp Thr Ala Met 
     130                135                140
Glu Gln Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Val Ser Asn 
 145                150                155                160
Phe Asn Pro Leu Gln Ile Glu Arg Ile Leu Asn Lys Pro Gly Leu Lys 
                 165                170                175
Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr Gln 
             180                185                190
Glu Lys Leu Ile Glu Tyr Cys His Cys Lys Gly Ile Val Val Thr Ala 
         195                200                205
Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu Asp 
     210                215                220
Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Glu Ile Ala Ala Lys Tyr 
 225                230                235                240
Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Ile Gln Arg Asn 
                 245                250                255
Leu Val Val Ile Pro Lys Ser Val Thr Pro Ala Arg Ile Ala Glu Asn 
             260                265                270
Phe Lys Val Phe Asp Phe Glu Leu Ser Asn Glu Asp Met Ala Thr Leu 
         275                280                285
Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Met Ser Cys Ala 
     290                295                300
Lys His Lys Asp Tyr Pro Phe His Ala Glu Val 
 305                310                315



<210> 3750
<211> 1367
<212> DNA
<213> Homo sapiens
<308> NM_001628
<400> 3750

gaaggccgc  ccgtactgg  cgggggtct  gggagcgca  cagccatgg  aagccgtct  60
ctgctcaac  acggcgcca  gatgcccat  ctggggttg  gtacctgga  gtcccctcc  120
gggcaggtg  ctgaggccg  gaaggtggc  attgacgtc  ggtaccgcc  catcgactg  180
gcccatgtg  accagaatg  gaatgaggt  ggggtggcc  ttcaggaga  gctcaggga  240
caggtggtg  agcgtgagg  gctcttcat  gtcagcaag  tgtggtgca  gtaccatga  300
aagggcctg  tgaaaggag  ctgccagaa  acactcagc  acctgaagc  ggactacct  360
gacctctac  ttattcact  gccgactgg  tttaagcct  ggaaggaat  tttcccatt  420
gatgagtcg  gcaatgtgg  tcccagtga  accaacatt  tggacacgt  ggcggccat  480
gaagagctg  tggatgaag  gctggtgaa  gctattggc  tctccaact  caaccatct  540
caggtggag  tgatcttaa  caaacctgg  ttgaagtat  agcctgcag  taaccagat  600
gagtgccac  catatctca  tcaggagaa  ttaatccag  actgccagt  caaaggcat  660
gtggtgacc  cctacagcc  cctcggctc  cctgacagg  cctgggcca  gcccgagga  720
ccttctctc  tggaggatc  caggatcaa  gcgatcgca  ccaagcaca  taaaactac  780
gcccaggtc  tgatccggt  ccccatgca  aggaacttg  tggtgatcc  caagtctgt  840
acaccagaa  gcattgctg  gaactttaa  gtctttgac  ttgaactga  cagccagga  900
atgaccacc  tactcagct  caacaggaa  tggagggtc  gtgccttgt  gagctgtac  960
tcccacaag  attacccct  ccatgaaga  ttttgaagc  gtggttgcc  gctcgtccc  1020
aagtgacct  tacctgtgt  tcttgcctc  tttttttcc  tgcaaatgt  gtatggcct  1080
tgtcactca  cagtgggac  gcaacctgt  gagtggcca  cgagggcgt  tctagcttg  1140
tgttggatc  caagagccc  gtcagtaga  tagaagtct  ttccagttt  ctttgccct  1200
ctttctacc  tgctgggga  agtacaacc  gaataccct  ttctgacca  agagaagca  1260
aatctacca  gtcaaaata  tgccactaa  ggttgagtt  tgactgctt  gaactggaa  1320
cctttcagc  agacttctc  ttgcctcaa  taaaaagtg  ttttgtg  1367



<210> 3751
<211> 315
<212> PRT
<213> Homo sapiens
<308> P15121
<400> 3751

Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu Gly 
  1               5                  10                  15
Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val Lys 
             20                  25                  30
Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val Tyr 
         35                  40                  45
Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg Glu 
     50                  55                  60
Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Leu Trp Cys 
 65                  70                  75                  80
Thr Tyr His Glu Lys Gly Leu Val Lys Gly Ala Cys Gln Lys Thr Leu 
                 85                  90                  95
Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro 
             100                105                110
Thr Gly Phe Lys Pro Gly Lys Glu Phe Phe Pro Leu Asp Glu Ser Gly 
         115                120                125
Asn Val Val Pro Ser Asp Thr Asn Ile Leu Asp Thr Trp Ala Ala Met 
     130                135                140
Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser Asn 
 145                150                155                160
Phe Asn His Leu Gln Val Glu Met Ile Leu Asn Lys Pro Gly Leu Lys 
                 165                170                175
Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr Gln 
             180                185                190
Glu Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Val Val Thr Ala 
         195                200                205
Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu Asp 
     210                215                220
Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Ala Ile Ala Ala Lys His 
 225                230                235                240
Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Met Gln Arg Asn 
                 245                250                255
Leu Val Val Ile Pro Lys Ser Val Thr Pro Glu Arg Ile Ala Glu Asn 
             260                265                270
Phe Lys Val Phe Asp Phe Glu Leu Ser Ser Gln Asp Met Thr Thr Leu 
         275                280                285
Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Leu Ser Cys Thr 
     290                295                300
Ser His Lys Asp Tyr Pro Phe His Glu Glu Phe 
 305                310                315



<210> 3752
<211> 15627
<212> DNA
<213> Rattus norvegicus
<308> M60322
<400> 3752

ggatccagg  agttcaaat  gcagagaag  ctctatgcc  agagggatt  cacagagga  60
aagtggcgg  tgtcaggtc  cctgttatc  tacacaaac  taatcccca  cactacact  120
aaattcaaa  tctactatt  agagaaaaa  tacacaaga  cttccacat  ccaacagct  180
tggggtttt  ttttgttaa  aaaatccaa  tggaaaata  ctgttcttt  taaattttc  240
cagggatgg  agtggaaga  tgccacctt  taggagggc  ccaactgga  aatcaccag  300
atggcactt  gagaggtgg  gttcctgac  cattactct  cagatgcag  tgtctgtgt  360
gcataatca  gggggcgac  gaagcatga  ccagcagaa  gagactcag  caaaacaga  420
catcacgca  aggggtgtt  gaagagtgc  aaatttccg  cattgttct  ggggcaact  480
cgattattt  agggaaagt  tttgttttt  tacccaata  caactgatt  atttatttt  540
tgtcccctt  acttggaat  attgctgta  gaaaacgga  ttttcctag  atgggattc  600
gcctgttca  ttttcttcc  gagagagtt  ggtcaactt  ctatactgg  acctgcccg  660
tcaacagtt  tactttccc  aatcattta  gtgtgatcc  gagatcaag  ttatgaggg  720
ttatagcta  cggttgctg  gtttcgcat  aaggcttgt  gaaccagat  gagcatgtt  780
agacactgg  aatggtaga  agctactac  agcgggcat  ttgtagtat  ttgcaaagc  840
ggttacaat  atttcaatt  agggggctg  gggaggggg  ggcttaaat  cacctgaag  900
ttaactttt  acataagac  aaaaaaaaa  aaaaaaaaa  aaaaaaagc  cttaagtac  960
cctgacgcc  atctgctcc  tcagtttca  aacaagatg  gcaggattc  agaagagta  1020
tattctgag  ttagaaaaa  acacaagcg  ctttttctg  cctctaaaa  gaaaccaaa  1080
ccttttccc  gtctcctta  ctctagtct  ccggttatt  tcagagcgt  tagtctggt  1140
cttcaacag  aggcaaaca  tctgccacg  ggggcgcag  gcagctgga  aattccgtg  1200
ctctaggac  tagggaaag  agcatcctc  ctgaccctt  aaggaccac  gaagagacc  1260
atcagaagg  gccgtctct  agccgtgcg  caatcgcag  cgtcctttc  gcaggctgt  1320
ggggctatt  aaaggtgcg  gccggagcc  gcgctgcac  cttgcgggt  gttgtgcgt  1380
acttgcagc  atcatggct  gccatctgg  actcaacaa  ggcaccaag  tgcccaccc  1440
gggtctggg  acctggaag  taggtgctc  tcagggcgt  gcccgccac  cgctgggtg  1500
ccctgagcg  cctgcgcgg  gcggggctc  ggtggttgg  gcctgtggg  gcatccggc  1560
gcggccccg  gtgtggggc  ctgggcgag  attgcgcga  tccgcgtgg  tgccccagg  1620
ggagacaca  ccacggggg  gagaggaac  gaagcaggg  tctagattt  tcatctggc  1680
ccccaaact  acgagtgag  tgacctcac  tggagcaga  gttgccctc  cgggaatga  1740
ccacttggc  gataggcct  agataatta  attaggagg  gagagtttg  agtgaacca  1800
cctgtttct  ttttcctta  atcgctgag  gcagctctt  acgggtgcg  aactcctct  1860
gaattaatc  ggtttccgc  ttgctgggt  ccaccctcc  caaacccca  cacaacaca  1920
caggcttga  aagacggcc  gatacgtta  agtgaaata  aaaaagaaa  aaccgataa  1980
taaaaacta  aaattataa  tgatttgat  atttgaaaa  taaggaacc  gttttggtg  2040
tattgctga  gcagaaaaa  ccagctctt  agctactgc  gtgacctgg  tctttaaga  2100
cctggagta  gggtgaacc  gggctgtat  taagcactt  gacacagtg  aggaaagag  2160
aaatcatgc  gggttgagt  cagatggtt  gaaactgga  agtctgttt  tacccagac  2220
acagttaaa  tgggtaatg  atatggtga  taagaaaca  gtcatagac  tgtctttct  2280
tgaatgtgt  tctaagcca  tagattagc  agtgcggct  tcgtttcct  ccaaagggt  2340
cttggtgac  gtaaagatg  gattgaatg  gaaccatca  accagatta  attctatgc  2400
ttggaagga  aagaaagat  gtttccttg  tgtaataaa  acagcacag  aaaggcaca  2460
ataactaca  tggttttgt  atacacgac  ctcaacatg  gtgggatgc  gatacttta  2520
ttctgtccc  tttctctaa  aaccaagct  ataacttta  aaaagcatt  tgagatcag  2580
tctcgggta  acacgagta  acattcata  gccggtggc  agagcggat  caacagccc  2640
agagagctg  gtgtttgtt  aaaattaca  acattttaa  gtatagatc  ttctgccgc  2700
ttcacagat  ttcctgtca  ttcccgcag  gcctggctt  tagaatgga  ccagaagtc  2760
tgttgagtt  gggcagggt  aagaaaatg  ctgcctgtg  ctgggggca  ggggaggtt  2820
gtgcagaga  cgtggaggg  cgaagggtg  cagtgagag  caggaggac  gccgagact  2880
ccagatttc  ttttttttt  ttttttttt  tttggttct  tttttttcg  agctgggga  2940
cgaacccag  gccttgcgc  tcctaggca  gcgctctac  actgagcta  atccccagc  3000
cccagattt  cctttttaa  aaaagaata  caacttaat  ctttccttg  acatgtgtg  3060
cgttccttc  tagatgaca  agtatatca  agtcactgt  atggtcaca  agggtgtgt  3120
ggtgcggtc  cttgttctg  aacttcatc  gtggccacc  ggtacctca  agaccacag  3180
gggactctg  cagggtatg  tccactctt  ccttgaggg  atctgtttc  cctgggagg  3240
gaggatttg  ggcagttgg  agacactct  acttgcatg  actttcttc  tggccaact  3300
gcctgccct  tggaccccc  aaatgcatg  taaatatac  atattacat  aaaatactg  3360
tttaagttt  gtgtggtca  gaggccttt  aggcagagc  ggcctgata  agaccacca  3420
gccctttta  tgataatgt  ttgacctag  tgaaaatct  tgaaggaca  ggccattgt  3480
tcttccaca  ataggctag  aattgctgc  aggaatgta  ggacagctg  gttctcaga  3540
tattttcca  ttaatgccc  ctgtgcctc  aaaccatga  tctcttgag  tgaactttt  3600
ttttctttt  ggcctaatt  tatcccaat  ggattctgg  atctcagat  aaactacta  3660
atatgtgct  acgccctgt  ttccctttc  cagggtcac  tggcattct  aagctgtga  3720
atattttct  tgcttgctt  ttgagtgtg  tttttgcct  tctgggata  tagtacttg  3780
ccttagaag  aaactgtgc  agggtcctc  tgccatttc  tgagttaaa  caagtgtcc  3840
ctgacagtc  tagagcctg  ggtcaggga  aaatgctgt  ctcattgaa  taggagttt  3900
gttttctgg  ggcctgcca  tgaccaggc  acactcctc  acctttcca  atttaagat  3960
aaaaaaaaa  atcaaatat  tcttgtcta  gcagggccg  tcctggagc  acatctctg  4020
ggagtggag  tgtgtctta  aatccggac  gctttattg  ccgataaca  tagaacacg  4080
tttattagt  ttgttgcta  actaggctg  gggctttca  tgttctcag  ctggggaaa  4140
ggccattct  gagggttca  tcttcatct  ttggaatca  cgttaaagt  cttgaactg  4200
gaggcgagg  tataccatc  aaacaaaca  gtgaggctg  tttctctca  tccagcagt  4260
ggaagtgct  tttgtggcg  ctgggtagg  catgaaagg  ggcacattg  gatcattct  4320
ggggttttc  gtcagagac  tggggaggt  gtacattta  gcctgttta  taagccacc  4380
gggttctgg  ctgtgtggg  aggaagccc  tggaagcag  gttctttct  ctgacctgc  4440
ctttgagcc  ttatctgtc  ttgtctttc  gtgaaaaca  cacacagaa  ttttttcct  4500
tgggttttg  tttggcgtc  gatgttcca  gacgtcgct  agtgtagtg  tggtctgcg  4560
cagtgtagt  tcagtgcat  ctgcactct  gcttggagg  acagaaaag  caggttaac  4620
tcacgcaga  ggcaagcag  aaagttggg  taggggtgg  gcctcattg  aatagccat  4680
acagtcact  gattcacgg  ttggattcc  ttctgggtt  taaattagg  taccagaat  4740
gagacgttt  agaccccat  ctctcaagg  gttgcgagc  ctcattctc  cagcaaagg  4800
ctccaggat  attcctcag  gggtgggcg  aggtcctga  atggagtac  atagccccg  4860
tcggctcac  ccatgttcc  gcttctgtg  gagtggctg  ggcaaatgt  gggtggctt  4920
gcccagcct  gaccttgtg  ccagcgctc  atccaaagc  aagctctgc  aggctctaa  4980
taggcttcc  acaaggcga  catgagagt  agcacaagg  ccctggatc  tgctataaa  5040
tcatcgtat  tccgaggca  gagaaacac  cacacactc  ccaggcccc  cttgtgtgg  5100
ctttctcaa  cagggattt  ccttttccc  cacagctag  accagccat  gctgtgtct  5160
gctgcccca  agggccctg  ccgggagag  ctttccctg  ataggccga  atagttcct  5220
taaccacag  aggaacctg  ggagaagct  agctacagg  gcactcttg  gtcctccag  5280
gaaatgaga  gggggccaa  cagtctaaa  gcacgtagt  aaggtaact  agtcctaag  5340
acgctgtgg  ccttccacc  ggcaggtcc  tccccactg  gtgaggagc  aagaccact  5400
cccacaggt  ctggggatg  gcttcttct  ctgtttgct  ttttatccc  tgactgttt  5460
gttcacaag  ctccagaca  aacagacgt  ggcggctgc  gatggcctt  gggagtttt  5520
tttttcatc  gattttgcc  cagctcgcc  gaggaatgt  ctgtgttcg  tcagcggcg  5580
ccagcgcag  gtcttgttt  gctctctag  cttggcaag  gcagcctgg  gatgggtaa  5640
agtgctgtg  agtccgggg  ctggtgaag  tcaggacta  gcaggctcc  cctcttctt  5700
ctcctcctc  gtggccagg  ttctcacgt  ccttaccaa  ctcaggtga  aatcttgca  5760
ggagccatc  tccctttcc  ctcacttct  tctgctgtt  cctctgaga  accacgtgt  5820
catgtccgt  cccacctcc  gggtcagca  cagttgagc  cttgttctg  gataaatgc  5880
atgaactat  tgagtgaaa  ggtgccttt  gttacatag  tcttggcta  tgctttttt  5940
tttttcttt  ttctgacca  gctacccca  acctcacag  gttcatgct  ctgccttca  6000
aggatcata  ctaggctgc  ggcctgtgg  tgtcaggct  tgctgaggt  aaattgaca  6060
ccctgtcgg  ggctgactg  aatgctgta  cataaatgc  tgttggcct  acatggcct  6120
acctcagaa  aggagcctg  tccaggatt  ctaacccca  tgtcctttc  cggctctgg  6180
caggcacgg  tctgtttgg  ttgggtttt  atcgatgac  gacattcct  cctttgcag  6240
ctcctcctg  ccaggtgac  gaggctgtg  aggttgcta  cgacatggg  tatcgccac  6300
ttgactgcg  ccaggtgta  cagaatgag  aggaggtgg  ggtggccct  caggagaag  6360
tcaaggagc  ggtggtgaa  cgccaggat  tcttcattg  cagcaaggt  ccaccaatc  6420
gtgaggatg  tggggtcca  ttcactccc  gccaggggg  cccagctgc  agtcaggtc  6480
acccttaac  tgatggcgg  tagtgctgg  cgggtggtg  acctgttac  tgtccacct  6540
tgtatctct  tgctgggcc  gtagatgag  gcctggttg  gggttgact  gcccttgta  6600
ggagtgact  cagggacag  gttaagtta  ttgacaaac  gggtttcac  gctggcctt  6660
agttttagc  agaggctgt  gatgtacaa  ggagcccag  ttggagggc  atgctggct  6720
catgtggac  agcttggct  ggaagtaga  ctagagcat  tgtttagca  ctcctgatc  6780
acagccgtg  ctcgtttag  ctctgtgag  tgctcttga  ctgaccacc  cacttgcct  6840
tgggaagtt  ggatccgca  tatgaactg  aaactctcc  gctactcct  gcgtcatgg  6900
tatggggag  ggagagcat  tgtgtcctc  gccttggga  tgtgtggct  ccagccggg  6960
agaggcatt  gcatggcag  gtaacctgt  ccgtttgct  gctccagct  tggtgcacg  7020
tccacgacc  gagcatggt  aaaggggcc  gccagaaga  gctgagcga  ctgcagctg  7080
actacctgg  cctctacct  attcactgg  caactggct  caaggtgag  ggcacacgg  7140
ggctggatc  gagcggttc  ggtgcggtc  tctctttct  ctcagcacc  tataggtgc  7200
tgactcatc  tgtctctgc  gcttggggt  tgcttctgg  ccagcatca  cgtcatcac  7260
taaaacgta  tagaaacca  cttcaggcc  ctctgcact  tctgaagcg  tggtggctc  7320
gatgcagcc  ttggagtct  ggggacacc  ctcttttca  tcagtgcct  cagaactta  7380
aactgacag  aaatatggc  gacaggact  ctgttgtcc  tgttgcaca  ggctgtagg  7440
gaagcctgc  ccgctgagt  tcctctggg  cttacatgt  atgcacgcc  gcgcgcgcg  7500
gcgcacgca  acacacaca  acacacaca  acacacaca  acacacaca  atgagtctg  7560
acctccgtt  catgccagt  tcatttgtg  ggtgacccg  agatctcag  gtcacttct  7620
gtatttctg  gtggtgacc  agatggaaa  gtcactggt  ttatcctcc  ctctgtttt  7680
gcttaccat  gtctcttgg  gcccgaggg  ctagatttt  accctgtgt  ttttatgac  7740
agccagaaa  agagaggca  agtgatagc  ttctaggtc  gagagccac  gagactcac  7800
gtgcctgag  ttccctacc  tgcccacag  cccttctcc  tgtcaggct  gggctcaga  7860
acttggata  gtctgaatc  ccatttgac  ccctcacag  tccagtcat  acagggatt  7920
ccatcgggg  cactttctg  ttccttttc  tcttggcta  cagatatac  tcttaccat  7980
ttccacagt  tgtagtgct  tgagattaa  aagtctgtg  agaagtgtc  ctgatgatt  8040
tgtgtgtgt  cttgttgtt  ctgacagcc  gggcctgac  atttccccc  ggatgcatc  8100
ggaaacgtg  ttcctagtg  caccgattt  gtggacact  ggacggtaa  atgcccctg  8160
ctgagaccc  tgtttattg  tggtaccct  ttattgtgt  caagccagg  gtgagtgat  8220
tgctctgcc  tgtcctgtg  ttagatcat  ccgtctctg  gtctgtctg  taagtctcg  8280
gaaagccag  ccagttttc  tcttggctt  tgaaagata  aagggtctg  ccgcggatg  8340
gagggctca  ctgtaaagt  ctggacaca  acatgcttc  ggttcttgt  ctcttggag  8400
tcattttag  actcagatc  cttttcttt  taggctatg  agcaactag  ggatgaagg  8460
ttggtaaaa  caatcggag  ctccaactt  aaccctctt  agattgaga  gatcttgaa  8520
aaacctggc  taaagtata  gcctgctgt  aaccaggta  gcgtcccca  gggaggatg  8580
tggcatgct  ttttaccag  cctggctct  gcctgtgga  cacagagag  agaagctct  8640
cagggatag  atttgaggc  agtcagcaa  gacgtggct  ctaacataa  ccgtgggta  8700
ctggtgaga  ctgcaggct  ttatctatt  ataatggcc  aggccaggg  aggccttat  8760
ggcttatgg  catagagca  tggcaacaa  attattctt  ctcttaatg  gaaggccat  8820
agctgggaa  tgtggagag  tgttccagc  tatctggga  gcagacatt  ctgtgtggg  8880
agaaaaggg  cattgacca  gtcacatga  tttgtgtcc  ctgccacag  cacccctcc  8940
gcttgtgtt  cagatcgag  gccacccat  cctaactca  gagaagctg  ttgagtact  9000
ccattgcaa  ggcatcgtg  tgactgcat  cagtcccct  ggttctcct  acaggccct  9060
gtgagcttc  gtgggagca  tgttggaga  aagaaataa  caaagggaa  gattggttg  9120
cagagagaa  gcttctgtg  tggctgcag  ccttccgtg  gtcctctgg  cttcctggg  9180
ggttcatgt  tctaggagc  agagatgga  atatattct  ttgcaaagg  tcagcaggt  9240
gatcatgac  cagcttcgg  ctaggagcc  gaccaacca  ccaggagtc  gtgggagga  9300
cagggctag  tggccggct  ccttgagtg  cagtggtga  gattgttga  ttccccatc  9360
ctctgctcc  gggccaagc  tgaggaccc  tctctcctg  aggatccca  gatcaagga  9420
attgcagcc  agtacaata  aactacagc  caggtatgg  tgcttcttg  tacttttga  9480
tgaactcta  actcacagt  gtccctgtc  gtcaggagt  gagggggct  agcctgaag  9540
cctctgtgg  agtgtggtt  ggagtccta  aatgcagtt  aggggcaca  atgtagaaa  9600
tgagagaat  aagtgacac  tggccctgg  acaatagtg  ctgtcccca  cgtctctat  9660
tgcggcaca  gcatcagcc  agcgtttag  gctgttctt  gaagctctt  ccggttact  9720
atagaagag  tcttactgc  tgcggtgtg  gaggtgttc  ctttcttcc  ggggtagtg  9780
gaccaggca  tgacttcct  tggccttgt  acatgcctg  agccactga  ggagcagga  9840
tgtagggtc  gatttgcac  aactcgtgg  tgtcacttg  cgtctcaca  cctctttgc  9900
tgtgcactt  ttgactgag  tggtaacac  gtgtattta  acactccac  cctctgcat  9960
cgcaggtgc  gatccggtt  cccatccaa  ggaacctgg  cgtgatccc  aagtctgtg  10020
caccagcac  tattgctga  aactttaag  taagatccc  gctccaggc  tggctttcc  10080
ccatggcag  tgggtcctg  gggttctcg  cctcccctt  ctttcccag  tgtgtgatt  10140
cgagcaagt  acttgacta  actcaaaac  gtgcctatg  tgagggctg  ggtgagact  10200
aagttcgtg  tgcacacgc  acagcactt  atagccctg  ttccacact  agtgctcag  10260
aaacattgc  gtgctggtg  tgggtccat  gacgcccag  acatacacc  atccactgg  10320
tctgttaag  cctaagcag  catgagcag  ggtgggaat  cttgggcac  aggagtgta  10380
gcatggaga  tgccctacc  ccaccactg  agcagctca  gctacctgg  gagaggcta  10440
ctgggaaag  gctgctcca  gacggtcct  ggaccacat  acaggagcc  ctggcccgt  10500
aaagcaaag  gatgctctg  cgaagtctg  ttcaaagtc  gccccacag  gtccacaat  10560
ggcactaga  tggttctga  gacatagta  gctactcta  tcctacctc  tcctcgtga  10620
cgtgaccat  cataccact  acatgtaac  atgtgggac  agagacatg  cctgctaga  10680
atgggttaa  acctcaccc  ataattcat  tctaaagta  tagggaaga  aacacagcc  10740
ggcggtggt  gcgcacacc  ttaatccca  cacttggga  tcagaggca  gtggatctg  10800
gagtttgag  ccagcctgg  ttgcagagc  agttccagg  cagccaggg  tacacagag  10860
aactgtctt  aaaaagaag  aagaatgtc  gtgaccaat  ttaacccac  gacctagtg  10920
ttcgttttt  tttgtttct  tttttcatc  tactgtgca  tttgcttgt  tctccatgg  10980
tgcagtcac  agagaatgt  gcagagtct  gtcctgcac  ttccgccat  agaatgtgc  11040
aagtggagt  ggttgtcag  gtgcagctc  atttccaag  cctggtgct  cggaaggcc  11100
tctggtcta  ttgtccacc  tgtacccta  cttcttttc  gtattctgt  gtggggtat  11160
caccggaga  gactaagca  acatgagtt  aaacaagta  aaagtcttt  ttagccagc  11220
tgtgactac  ctgggtgtt  gggatccca  gcctttctc  gggtttaag  acacaatca  11280
atcttgggt  tgatacacc  cagttaaca  gaacaatta  ccagaggta  aactgcaga  11340
gccagaagg  gaggctagc  catgtagag  cttttccag  actatggac  ttgatgtga  11400
ttaaaaata  aaacaaaca  aaaaattag  aaggaaagg  catgactgc  cctgaaccg  11460
ggggttggg  tgaggggga  caagtacaa  agccaggaa  ccaaaggta  aaaaggagc  11520
aagtgggta  taagggaac  gtcgggctg  ataggggag  ggctggaga  ctgagtaga  11580
ggtgggtgt  cccgccaca  cctgtaatt  gtagggact  aagggtatt  aacctggag  11640
ccaggtctg  ttagctacc  taaataggc  ccttagacg  ttgccctgg  attgaaatt  11700
aacagcagg  tagccccag  tctggcaca  aacacccca  gactgtaat  catccttca  11760
cttcacctt  gctgggtgt  ttgcttggt  tttgatttg  ctgacggtg  tgtgtacct  11820
ctgagtttt  tgacttgaa  ggtacttcc  tccatcatg  agtcagtgt  ctagggtct  11880
ttacatatt  ctgtattca  tcttttgtc  tcgtggaag  ctttcttgc  ctgtatgtc  11940
aaacctgac  tattttctt  ggccttgtc  cacatggat  cgcgaggca  tgtccttcg  12000
tccccagct  gagtgcctt  ctggggaca  cccagagcc  ttctttcat  acagcgcag  12060
acccagaac  cggattaat  ggtgttcca  ctattgagg  gtctcctct  acacttctg  12120
tgaatggag  agtcaggac  ctcagtaac  tttcccctg  tgcttatca  agtagagcg  12180
ctcaggagc  tgacaggaa  gactgaaca  tgccctctg  ttggaaatc  tggaaggga  12240
aggccattt  agatagggc  acaagcctg  accttctgg  gcataatta  cagtcttct  12300
gaagtccca  gtcctctcc  gccctctgc  ctccaggca  tgagggcca  ctggaactt  12360
ctgctttgt  tctgtttta  tgtgagctt  ttgactttg  ttctttcct  catgtttgt  12420
tgtaaggtc  ttgactttg  gctgagcaa  gaggacatg  ccactctac  cagctacaa  12480
aggaactgg  gggtgtgcg  cttgatgag  tgagttcca  tgtggtgcc  gttctacct  12540
ttctatgtc  ccaaatgtt  agactaaca  gcatctctc  ggccccaga  gcagggtcc  12600
tcccctgca  cccgccctg  tttcacaca  accttgtct  ctaatctat  cagacccgg  12660
ggcactgca  aaagccagg  gagggtggc  gtcaggaga  ctgcctggg  gcacagttg  12720
tccactttg  cttttctga  ctcagatgg  cccaggggc  tctctggta  ccaccttcc  12780
agaagagtt  gcatgtgac  gattgactt  atgacgcta  cgaggagtt  ggtaggaag  12840
ccctggtgc  gggctcagg  tagccccag  tctggcaca  aacaccctg  gactgtaat  12900
ccactcaga  ggctgtaat  ccactcaga  ggctgtaat  ccactcaga  ggcttaatg  12960
cactcgggc  cccagggcc  ttcagcttc  cctctgctg  ttttttgct  ccctctgaa  13020
tggggtttg  actccgaat  cctggggat  agtttgctt  aagaagcag  ctgtgtccc  13080
aatgcctgc  ttgtcttcc  gtcttgatt  tcactcaca  tctcttgct  tcactcgcc  13140
tctgcataa  tcggtgttt  cctggtggt  gccgcaacc  ctacggtct  tataggcag  13200
aaggtttgt  attcgggct  tttacatgt  gccatcaca  agtcctcag  ttctaagta  13260
gctgtaaac  gaactagcc  aggactctg  aacaggacc  tttctgata  tacactaag  13320
acgtttaac  ttttaatgt  aaaatcatc  tttactttg  atctaacgg  caggagaga  13380
gcgaatcac  tgcctgtag  atccatccg  ttcctagag  ctgtagtag  taagtcact  13440
agccctgcg  gttccctgg  actgctgat  ctgacatca  agcttgtgg  gagagcaaa  13500
cctttgtgt  tgctcacct  cttgcacct  ccatgacta  tctagaagc  gctgtgctt  13560
gacagtact  agttgacat  ggttgcagt  ggggttggg  caggggcgg  ctctagtgc  13620
cccagcaaa  ctttcctaa  atgccagcc  tcctgtgga  acacacggc  atactgagc  13680
cttgctgct  gtgtctgag  ccaggatgc  aagaaaggc  gttgcgggg  agcttgagt  13740
atctgagtg  tcagtgaga  ctgcatacc  ggggcctgg  tcatcctca  cctctgggg  13800
gtggaaaga  acgagcagt  cacttttgc  tggattcta  aagagaagc  caacctcag  13860
cgaaaacat  ctcatcttc  gaggagtag  gcaaccttt  ttagtttga  ttgattaag  13920
aagaaatga  ctttcttat  tttgattta  cttcctgct  ttctccaaa  agcaggagc  13980
gtctgggac  tcatggtat  gtctctgat  ttttattgc  gaattaact  gattttttt  14040
taatgtgag  gtgtgtgtg  cacactagt  gtcctttga  tccaacatg  gcgcgcacg  14100
gcacacaca  acacacaca  acacacaca  acacacaca  acacacaca  acacacaca  14160
acacacacg  gttcaggct  tgacactgt  cctgcctag  ttctctagt  ttcttgcca  14220
tttgttccc  ttataagcc  ttggcccta  caaatagac  gtgaacctt  gctccatgc  14280
agcccttgc  ctgttcctg  agtacatcc  cagctgctg  taggtgctc  tttcactcc  14340
gatgtcaca  aggggcctc  cctttcctg  gagtggctg  ctgtttgac  tgcccttca  14400
ggttcagtg  ggtacagct  gtaaaccct  ctactgctt  gttatctct  ttcttttgg  14460
cctgtgttc  ggagctgat  aaatgaact  ggtgtagtg  cacacgcct  taatcccag  14520
acttgggag  tggagtcag  aagacctga  cttcaaggt  atcctcagc  aagcagtgt  14580
tttgaggcc  gccccgcct  accagaccc  gtcttaaaa  acagcagaa  gttgacatg  14640
ggctgtatg  tcctgccag  tcctcagag  tcccacgca  gacttgctg  ccagtgtgc  14700
ccaggctag  gcttagtgc  gcctgtcac  tgatgcagt  cctgacatc  caagacaag  14760
ggagctcag  gcctgagta  ctgtaccta  gatcagaag  ctctaagac  gctcagtcc  14820
cagtgagac  ccgtttctc  gtgttggtg  ctcgttcgt  acagacaga  tctttttcc  14880
tgagagctg  caaggtggt  cagagtgtt  agacatttg  atcaatcct  aggataaac  14940
gagtttatc  aggacccac  cgataggag  gaagcaact  acactaaat  aataagtga  15000
cccaattaa  tttaggaag  ctttaactt  taaattgca  gtattcttt  ctgacagct  15060
tgccaaaca  aaggattac  ccttccacg  agaagtctg  agctgtggt  gacgaatcc  15120
gctcctccc  aagcgactt  acacatgtt  tttctgcct  atctgccct  gcaagtgtc  15180
ctctgcact  ggtggcacc  tgcagacca  atggtgaga  tttgttagt  tgacgtaga  15240
tgtggaggg  agtaccagt  gctgaggag  ttcttcggc  tttcttggt  ttcttccca  15300
ctggaggac  ttaacacga  taccttttc  aaccaaaga  aaagcaaga  ttatagccc  15360
agtcatgcc  ctaacactt  aatttgagt  cttagaact  cagtcctat  ggggtcaga  15420
tttttgcct  aaataaaaa  tgcttttgt  aatttggtg  tcgtctgtt  tgcttttgc  15480
ctgtaatac  gtgcacccc  tctgcccca  acccagcct  agtgccaag  acaggccag  15540
gctgtgaac  aactgagaa  tcgtatcct  gcacgacac  gcagagtgt  agggtggtg  15600
gtagcatcc  ggtgacatg  tgagctc  15627



<210> 3753
<211> 315
<212> PRT
<213> Rattus norvegicus
<308> AAA40721
<400> 3753

Ala Ser His Leu Glu Leu Asn Asn Gly Thr Lys Met Pro Thr Leu Gly 
  1               5                  10                  15
Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val Lys 
             20                  25                  30
Val Ala Ile Asp Met Gly Tyr Arg His Ile Asp Cys Ala Gln Val Tyr 
         35                  40                  45
Gln Asn Glu Lys Glu Val Gly Val Ala Leu Gln Glu Lys Leu Lys Glu 
     50                  55                  60
Gln Val Val Lys Arg Gln Asp Leu Phe Ile Val Ser Lys Leu Trp Cys 
 65                  70                  75                  80
Thr Phe His Asp Gln Ser Met Val Lys Gly Ala Cys Gln Lys Thr Leu 
                 85                  90                  95
Ser Asp Leu Gln Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro 
             100                105                110
Thr Gly Phe Lys Pro Gly Pro Asp Tyr Phe Pro Leu Asp Ala Ser Gly 
         115                120                125
Asn Val Ile Pro Ser Asp Thr Asp Phe Val Asp Thr Trp Thr Ala Met 
     130                135                140
Glu Gln Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Val Ser Asn 
 145                150                155                160
Phe Asn Pro Leu Gln Ile Glu Arg Ile Leu Asn Lys Pro Gly Leu Lys 
                 165                170                175
Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr Gln 
             180                185                190
Glu Lys Leu Ile Glu Tyr Cys His Cys Lys Gly Ile Val Val Thr Ala 
         195                200                205
Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu Asp 
     210                215                220
Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Glu Ile Ala Ala Lys Tyr 
 225                230                235                240
Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Ile Gln Arg Asn 
                 245                250                255
Leu Val Val Ile Pro Lys Ser Val Thr Pro Ala Arg Ile Ala Glu Asn 
             260                265                270
Phe Lys Val Phe Asp Phe Glu Leu Ser Asn Glu Asp Met Ala Thr Leu 
         275                280                285
Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Met Ser Cys Ala 
     290                295                300
Lys His Lys Asp Tyr Pro Phe His Ala Glu Val 
 305                310                315



<210> 3754
<211> 1367
<212> DNA
<213> Homo sapiens
<308> NM_001628
<400> 3754

gaaggccgc  ccgtactgg  cgggggtct  gggagcgca  cagccatgg  aagccgtct  60
ctgctcaac  acggcgcca  gatgcccat  ctggggttg  gtacctgga  gtcccctcc  120
gggcaggtg  ctgaggccg  gaaggtggc  attgacgtc  ggtaccgcc  catcgactg  180
gcccatgtg  accagaatg  gaatgaggt  ggggtggcc  ttcaggaga  gctcaggga  240
caggtggtg  agcgtgagg  gctcttcat  gtcagcaag  tgtggtgca  gtaccatga  300
aagggcctg  tgaaaggag  ctgccagaa  acactcagc  acctgaagc  ggactacct  360
gacctctac  ttattcact  gccgactgg  tttaagcct  ggaaggaat  tttcccatt  420
gatgagtcg  gcaatgtgg  tcccagtga  accaacatt  tggacacgt  ggcggccat  480
gaagagctg  tggatgaag  gctggtgaa  gctattggc  tctccaact  caaccatct  540
caggtggag  tgatcttaa  caaacctgg  ttgaagtat  agcctgcag  taaccagat  600
gagtgccac  catatctca  tcaggagaa  ttaatccag  actgccagt  caaaggcat  660
gtggtgacc  cctacagcc  cctcggctc  cctgacagg  cctgggcca  gcccgagga  720
ccttctctc  tggaggatc  caggatcaa  gcgatcgca  ccaagcaca  taaaactac  780
gcccaggtc  tgatccggt  ccccatgca  aggaacttg  tggtgatcc  caagtctgt  840
acaccagaa  gcattgctg  gaactttaa  gtctttgac  ttgaactga  cagccagga  900
atgaccacc  tactcagct  caacaggaa  tggagggtc  gtgccttgt  gagctgtac  960
tcccacaag  attacccct  ccatgaaga  ttttgaagc  gtggttgcc  gctcgtccc  1020
aagtgacct  tacctgtgt  tcttgcctc  tttttttcc  tgcaaatgt  gtatggcct  1080
tgtcactca  cagtgggac  gcaacctgt  gagtggcca  cgagggcgt  tctagcttg  1140
tgttggatc  caagagccc  gtcagtaga  tagaagtct  ttccagttt  ctttgccct  1200
ctttctacc  tgctgggga  agtacaacc  gaataccct  ttctgacca  agagaagca  1260
aatctacca  gtcaaaata  tgccactaa  ggttgagtt  tgactgctt  gaactggaa  1320
cctttcagc  agacttctc  ttgcctcaa  taaaaagtg  ttttgtg  1367



<210> 3755
<211> 315
<212> PRT
<213> Homo sapiens
<308> P15121
<400> 3755

Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu Gly 
  1               5                  10                  15
Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val Lys 
             20                  25                  30
Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val Tyr 
         35                  40                  45
Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg Glu 
     50                  55                  60
Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Leu Trp Cys 
 65                  70                  75                  80
Thr Tyr His Glu Lys Gly Leu Val Lys Gly Ala Cys Gln Lys Thr Leu 
                 85                  90                  95
Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro 
             100                105                110
Thr Gly Phe Lys Pro Gly Lys Glu Phe Phe Pro Leu Asp Glu Ser Gly 
         115                120                125
Asn Val Val Pro Ser Asp Thr Asn Ile Leu Asp Thr Trp Ala Ala Met 
     130                135                140
Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser Asn 
 145                150                155                160
Phe Asn His Leu Gln Val Glu Met Ile Leu Asn Lys Pro Gly Leu Lys 
                 165                170                175
Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr Gln 
             180                185                190
Glu Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Val Val Thr Ala 
         195                200                205
Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu Asp 
     210                215                220
Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Ala Ile Ala Ala Lys His 
 225                230                235                240
Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Met Gln Arg Asn 
                 245                250                255
Leu Val Val Ile Pro Lys Ser Val Thr Pro Glu Arg Ile Ala Glu Asn 
             260                265                270
Phe Lys Val Phe Asp Phe Glu Leu Ser Ser Gln Asp Met Thr Thr Leu 
         275                280                285
Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Leu Ser Cys Thr 
     290                295                300
Ser His Lys Asp Tyr Pro Phe His Glu Glu Phe 
 305                310                315



<210> 3756
<211> 2519
<212> DNA
<213> Rattus norvegicus
<308> M60921
<400> 3756

agagcccgt  aggcggccg  accatcatc  tcctgctaa  acagctact  cctcaacca  60
cggtatgag  cacgggaag  gaaccgaca  gctcccgga  atcgccgcc  ccgtaggtt  120
cctcaccag  ctcctgagg  ctcggggct  cgtgagcga  cagagactc  aggttttca  180
tagggcgct  caggacgca  tgaccgatc  ttacaaaca  cactggttt  cagaaaagc  240
atccaaggg  tccggctat  gctgtatcc  catcaacca  aagatggac  ccatcatca  300
caaggtggc  agccagatc  gactcagcc  gccccagct  caccagctc  tgcccagcg  360
gctgaccct  tgggtcgat  cctacgaag  gtcctaccg  atcggggaa  atggatcca  420
ctgcgtgct  tatgaggag  cgccggtgg  cacctccta  gggctcctc  cctgcaaga  480
ccagatgat  ctgggcagg  gcagtccat  gaagaacta  gtgatgact  tctccagct  540
gagaggagc  gccccgccc  ggcactcta  tgttctcat  ctgccctga  aacaggcca  600
cgtatacct  aacctgggg  actgtattt  taaagtgaa  agctattta  acatgttat  660
ttttttttt  agaaaagag  aggaaaaaa  ccaaaagtt  ttttttaaa  aaacaaaaa  720
gaaaaaaca  ttcgttaac  ggagctgct  ggaagtggt  tccccaggt  cctttggag  780
gaactgttc  tgattgagt  tatgagcca  tgtttgcct  ggggagtgg  ttggggatt  840
gcctagcca  ggtaaaagg  gattcttgg  tgatccccc  ggaggtggt  gaagggagc  900
aggttagca  ctgtgaacg  gaggggtca  ggtctgctc  gggttaccg  tcccgctgg  960
atgcctgta  tcctggtcc  tctcttact  aggggcatt  aagcctggt  tcaaataat  1020
ctacattgc  taatcttct  ttttgtttt  ctgctgaga  cctgggcac  cggaaaggc  1080
tctcctgtc  cttccgtct  agcagagtt  cttgaaact  tgtctcgtt  ctgatccta  1140
cctcggggt  ctgaagagg  ggtttcccg  cctagaatc  atctaaacg  ttttggagg  1200
tgggctata  ggcagatat  atggagggg  accgcacaa  ccctttgct  tgctctgtg  1260
tgctttgta  ggatggatg  ttaataact  agggatgat  tgcaatgga  ttttgggac  1320
caaagagta  ccaatgggg  tgggtgttt  ggacctaag  cctcctttt  ggaaccacg  1380
gacagtctg  atgctgcta  cattattcc  ttgagaggt  gctcaaagc  ccagggaac  1440
ccaggtcct  tcttactgc  ttctcttca  gagcaacct  ccccatttc  tttccctct  1500
tcctgcggt  gggtcctgg  gggccccat  tcctaggac  agagttctc  atcactgtg  1560
aatagtccc  ggaagctct  gaactgggc  tcccagccc  tcctgattc  tggtgggtt  1620
taggacccc  ccttccccg  tcttctgac  ggctggtgg  ccttgagga  atctccctc  1680
gccgcaggg  gggcacctg  gcactgcag  actacctgg  actcctgtg  ggctgccac  1740
gagagccaa  ccttaggca  agctttgtc  cctcggtgc  cagagcacc  gcaggggga  1800
gttgccccc  tcagtaaaa  tccaaattt  tttgtagat  tgtgcaata  ttactgttc  1860
gggttggag  aaatcggga  acactggga  gaagtggcc  tccttcagg  tcagtgaca  1920
tgatgaggg  ttctcagaa  gcctcgagt  tctcaaacc  aaggacaga  ctagagcca  1980
ccagtcacc  ttagtgagg  tccccttcc  catgtctct  cactgccgt  gcatcccat  2040
tcctggatt  ctcaattcc  cagtttcta  tcaaaggtg  tacttacca  acactctgc  2100
cgtcccgct  tccccagct  cgcacagcc  tcccaggtg  cttcgtctc  cctgcttta  2160
agttaactt  gggcccaca  acccgagag  tgtgggttg  agcaaagct  tgaatcgct  2220
cagatggtc  ctgtgttct  tccacacac  ggtccccgc  tttttagaa  cagcctcct  2280
gtctcatgc  taaatctgt  cctcactgc  cgtgttcac  ttagaaatg  cagaaccac  2340
gagctggac  gttgagcag  cctgtctct  tcattaaat  gaaataagt  agtttgtaa  2400
ctattccga  agaagagac  aaggttact  attgtacaa  agcgctttt  tatggaaga  2460
tgtacagct  tatggacaa  tgtaaaact  ttttgtttt  aataaaaat  tagcagacc  2519



<210> 3757
<211> 158
<212> PRT
<213> Rattus norvegicus
<308> P27049
<400> 3757

Met Ser His Gly Lys Arg Thr Asp Met Leu Pro Glu Ile Ala Ala Ala 
  1               5                  10                  15
Val Gly Phe Leu Thr Ser Leu Leu Arg Thr Arg Gly Cys Val Ser Glu 
             20                  25                  30
Gln Arg Leu Lys Val Phe Ser Arg Ala Leu Gln Asp Ala Leu Thr Asp 
         35                  40                  45
His Tyr Lys His His Trp Phe Pro Glu Lys Pro Ser Lys Gly Ser Gly 
     50                  55                  60
Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Ile Ile Ser Lys 
 65                  70                  75                  80
Val Ala Ser Gln Ile Gly Leu Ser Gln Pro Gln Leu His Gln Leu Leu 
                 85                  90                  95
Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser Tyr Arg 
             100                105                110
Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Glu Ala Pro Val 
         115                120                125
Ala Thr Ser Tyr Gly Leu Leu Thr Cys Lys Asn Gln Met Met Leu Gly 
     130                135                140
Arg Ser Ser Pro Ser Lys Asn Tyr Val Met Thr Val Ser Ser 
 145                150                155



<210> 3758
<211> 2717
<212> DNA
<213> Homo sapiens
<308> U72649
<400> 3758

cagggtaac  ctgtcttgt  gacccgcac  tcccacccg  gacctctca  tgagcccga  60
ccgcgcgcg  catgagcca  gggaaggga  ccgacatgc  cccggagat  gccgccgcc  120
tgggcttcc  ctccagcct  ctgaggacc  ggggctgcg  gagcgagca  aggcttaag  180
tcttcagcg  ggcgctcca  gaggcactc  cagagcact  caaacacca  tggtttccc  240
aaaagccgt  caagggctc  ggctaccgc  gcattcgca  caaccacaa  atggacccc  300
tcatcagca  ggtggccag  cagatcgga  tcagccagc  ccagctgca  cagctgctg  360
ccagcgagc  gaccctgtg  gtggacccc  atgaggtgt  ctaccgcat  ggggaggac  420
gctccatct  cgtcttgta  gaggaggcc  cactggccg  ctcctgtgg  ctcctcacc  480
gcaagaacc  agtgctgct  ggccggagc  gcccctcca  gaactacgt  atggcagtc  540
ccagctagg  ccttccgcc  ccgccctgg  cgccgccgt  ctcatgctg  cgtgacaac  600
ggccaccac  tacctcaac  tggggaact  tatttttaa  tgaagagct  tttatatat  660
ttatttttt  ttaagaaag  aggaaaaga  accaaaagt  ttttttaag  aaaaaaatc  720
ttcaaggga  ctgcttgga  gtggcctcc  caggtgcct  tggagagaa  tgttgcgtg  780
ttgagtctg  gagccagtg  ctgcctata  gagggggag  tgttagggg  tagacctag  840
caaggagaa  tgggagacg  ttggctagc  ccccaggaa  atgtgagag  gagcaagca  900
ggttagcaa  tgtgaacag  gaggtcggg  tttgccctg  gggaggaag  gaggccaag  960
tcagagctc  ctgtctccc  cagccagac  cctgcatcc  tggctcctc  attactcag  1020
ggcattcat  cctggactt  aacaatact  tgttatctt  tcttttatt  ttctaatga  1080
gtcctgggc  gagagtgaa  aggcctctc  tgattccta  tgtcctaag  tgcttttct  1140
gaaatcatg  cttgtttct  attctaccc  caggggcct  tagatgttg  tttccagcc  1200
ggaatctaa  gctttgggt  ttctgaggg  gggaggagg  aactggagg  tattggggt  1260
aggatggaa  ggaactctg  acaaaacct  tgctttgct  gtgctgctt  gtgtgtatg  1320
gtggcaaat  atttggggg  gatttgcaa  gaaattttg  gacccaaag  gtatccact  1380
gggatgttt  ttggccaaa  ctcttcctt  tggaaccac  tgaaagtct  gatgctgct  1440
ccatgatcc  tttgagagg  ggctcaaaa  ctacaggga  ctccaggtc  tttattact  1500
ccttctttt  aaaagcaca  ctctcctct  accctcccc  cccccttcc  ttctggtcg  1560
gtcatagag  taccgtatt  tctaggaca  gagttctca  tcactgtgc  atatgcccc  1620
tgggtccca  gagggtctg  aggaaaact  gctatcaga  cctcctgat  ccctggtgg  1680
cttagggaa  catctctcc  gctctcctt  ggatgatgg  tggctagtc  gccttgcat  1740
tattccttg  ctgaatggg  gagtgcccc  tgttctgca  gactacttg  tattcttgt  1800
gggccgaca  taaataaaa  ccaaacctt  ggcactgtt  tttctccct  gtgctcaga  1860
cacctgtgg  aaaggttgc  gtctgtctc  gtacaatcc  aatttgtcg  agacttgtg  1920
aatatatac  gttgtgggt  ggagaaaag  ggaaagcta  actgggaag  aactccctt  1980
cttcaattt  tcagtgaca  tgatgaggg  tcctcaaaa  acctcgagt  tcccaaacc  2040
aatcacctt  agaaggaca  ggctagggc  tttggccag  atggccacc  tcctgctgt  2100
gccccttag  gaggaatct  caccccact  cctctaccc  caggttctc  tccccacag  2160
cagtcccct  tcctggatt  ctaaactgc  caattttga  tcaaaggtg  tatttacca  2220
acactctcc  tacccattc  tgccagctc  gcctccttt  caactctcc  cattttgta  2280
tgccttccc  gacctgctt  cagtcttta  tgctttaaa  ttcactttg  gcccacaga  2340
ccaagagct  attttctgg  ttgtgggtt  aaacaaagc  gtgaatcac  gcaggctgt  2400
ttcttgcat  ttgtctgca  acaggtccc  gccttttta  aagcagcct  atggtctca  2460
gcttaatct  gtctctctt  tcttcttta  gatgttcac  ttaaaaaca  caaaacccc  2520
gagctggac  gttgagcag  cctgtctct  ctattaagt  aaaataaat  gtagtagta  2580
gtttgtaag  tattctgac  gaaaagaca  aggttacta  ttgtatgat  gtgttttta  2640
atggaagaa  gtacagctt  tggacaaat  tacaccttt  tgttacttt  ataaaaatg  2700
agtaggata  aaaaaaa  2717



<210> 3759
<211> 158
<212> PRT
<213> Homo sapiens
<308> P78543
<400> 3759

Met Ser His Gly Lys Gly Thr Asp Met Leu Pro Glu Ile Ala Ala Ala 
  1               5                  10                  15
Val Gly Phe Leu Ser Ser Leu Leu Arg Thr Arg Gly Cys Val Ser Glu 
             20                  25                  30
Gln Arg Leu Lys Val Phe Ser Gly Ala Leu Gln Glu Ala Leu Thr Glu 
         35                  40                  45
His Tyr Lys His His Trp Phe Pro Glu Lys Pro Ser Lys Gly Ser Gly 
     50                  55                  60
Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Ile Ile Ser Arg 
 65                  70                  75                  80
Val Ala Ser Gln Ile Gly Leu Ser Gln Pro Gln Leu His Gln Leu Leu 
                 85                  90                  95
Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser Tyr Arg 
             100                105                110
Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Glu Ala Pro Leu 
         115                120                125
Ala Ala Ser Cys Gly Leu Leu Thr Cys Lys Asn Gln Val Leu Leu Gly 
     130                135                140
Arg Ser Ser Pro Ser Lys Asn Tyr Val Met Ala Val Ser Ser 
 145                150                155



<210> 3760
<211> 2519
<212> DNA
<213> Rattus norvegicus
<308> M60921
<400> 3760

agagcccgt  aggcggccg  accatcatc  tcctgctaa  acagctact  cctcaacca  60
cggtatgag  cacgggaag  gaaccgaca  gctcccgga  atcgccgcc  ccgtaggtt  120
cctcaccag  ctcctgagg  ctcggggct  cgtgagcga  cagagactc  aggttttca  180
tagggcgct  caggacgca  tgaccgatc  ttacaaaca  cactggttt  cagaaaagc  240
atccaaggg  tccggctat  gctgtatcc  catcaacca  aagatggac  ccatcatca  300
caaggtggc  agccagatc  gactcagcc  gccccagct  caccagctc  tgcccagcg  360
gctgaccct  tgggtcgat  cctacgaag  gtcctaccg  atcggggaa  atggatcca  420
ctgcgtgct  tatgaggag  cgccggtgg  cacctccta  gggctcctc  cctgcaaga  480
ccagatgat  ctgggcagg  gcagtccat  gaagaacta  gtgatgact  tctccagct  540
gagaggagc  gccccgccc  ggcactcta  tgttctcat  ctgccctga  aacaggcca  600
cgtatacct  aacctgggg  actgtattt  taaagtgaa  agctattta  acatgttat  660
ttttttttt  agaaaagag  aggaaaaaa  ccaaaagtt  ttttttaaa  aaacaaaaa  720
gaaaaaaca  ttcgttaac  ggagctgct  ggaagtggt  tccccaggt  cctttggag  780
gaactgttc  tgattgagt  tatgagcca  tgtttgcct  ggggagtgg  ttggggatt  840
gcctagcca  ggtaaaagg  gattcttgg  tgatccccc  ggaggtggt  gaagggagc  900
aggttagca  ctgtgaacg  gaggggtca  ggtctgctc  gggttaccg  tcccgctgg  960
atgcctgta  tcctggtcc  tctcttact  aggggcatt  aagcctggt  tcaaataat  1020
ctacattgc  taatcttct  ttttgtttt  ctgctgaga  cctgggcac  cggaaaggc  1080
tctcctgtc  cttccgtct  agcagagtt  cttgaaact  tgtctcgtt  ctgatccta  1140
cctcggggt  ctgaagagg  ggtttcccg  cctagaatc  atctaaacg  ttttggagg  1200
tgggctata  ggcagatat  atggagggg  accgcacaa  ccctttgct  tgctctgtg  1260
tgctttgta  ggatggatg  ttaataact  agggatgat  tgcaatgga  ttttgggac  1320
caaagagta  ccaatgggg  tgggtgttt  ggacctaag  cctcctttt  ggaaccacg  1380
gacagtctg  atgctgcta  cattattcc  ttgagaggt  gctcaaagc  ccagggaac  1440
ccaggtcct  tcttactgc  ttctcttca  gagcaacct  ccccatttc  tttccctct  1500
tcctgcggt  gggtcctgg  gggccccat  tcctaggac  agagttctc  atcactgtg  1560
aatagtccc  ggaagctct  gaactgggc  tcccagccc  tcctgattc  tggtgggtt  1620
taggacccc  ccttccccg  tcttctgac  ggctggtgg  ccttgagga  atctccctc  1680
gccgcaggg  gggcacctg  gcactgcag  actacctgg  actcctgtg  ggctgccac  1740
gagagccaa  ccttaggca  agctttgtc  cctcggtgc  cagagcacc  gcaggggga  1800
gttgccccc  tcagtaaaa  tccaaattt  tttgtagat  tgtgcaata  ttactgttc  1860
gggttggag  aaatcggga  acactggga  gaagtggcc  tccttcagg  tcagtgaca  1920
tgatgaggg  ttctcagaa  gcctcgagt  tctcaaacc  aaggacaga  ctagagcca  1980
ccagtcacc  ttagtgagg  tccccttcc  catgtctct  cactgccgt  gcatcccat  2040
tcctggatt  ctcaattcc  cagtttcta  tcaaaggtg  tacttacca  acactctgc  2100
cgtcccgct  tccccagct  cgcacagcc  tcccaggtg  cttcgtctc  cctgcttta  2160
agttaactt  gggcccaca  acccgagag  tgtgggttg  agcaaagct  tgaatcgct  2220
cagatggtc  ctgtgttct  tccacacac  ggtccccgc  tttttagaa  cagcctcct  2280
gtctcatgc  taaatctgt  cctcactgc  cgtgttcac  ttagaaatg  cagaaccac  2340
gagctggac  gttgagcag  cctgtctct  tcattaaat  gaaataagt  agtttgtaa  2400
ctattccga  agaagagac  aaggttact  attgtacaa  agcgctttt  tatggaaga  2460
tgtacagct  tatggacaa  tgtaaaact  ttttgtttt  aataaaaat  tagcagacc  2519



<210> 3761
<211> 158
<212> PRT
<213> Rattus norvegicus
<308> P27049
<400> 3761

Met Ser His Gly Lys Arg Thr Asp Met Leu Pro Glu Ile Ala Ala Ala 
  1               5                  10                  15
Val Gly Phe Leu Thr Ser Leu Leu Arg Thr Arg Gly Cys Val Ser Glu 
             20                  25                  30
Gln Arg Leu Lys Val Phe Ser Arg Ala Leu Gln Asp Ala Leu Thr Asp 
         35                  40                  45
His Tyr Lys His His Trp Phe Pro Glu Lys Pro Ser Lys Gly Ser Gly 
     50                  55                  60
Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Ile Ile Ser Lys 
 65                  70                  75                  80
Val Ala Ser Gln Ile Gly Leu Ser Gln Pro Gln Leu His Gln Leu Leu 
                 85                  90                  95
Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser Tyr Arg 
             100                105                110
Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Glu Ala Pro Val 
         115                120                125
Ala Thr Ser Tyr Gly Leu Leu Thr Cys Lys Asn Gln Met Met Leu Gly 
     130                135                140
Arg Ser Ser Pro Ser Lys Asn Tyr Val Met Thr Val Ser Ser 
 145                150                155



<210> 3762
<211> 2717
<212> DNA
<213> Homo sapiens
<308> U72649
<400> 3762

cagggtaac  ctgtcttgt  gacccgcac  tcccacccg  gacctctca  tgagcccga  60
ccgcgcgcg  catgagcca  gggaaggga  ccgacatgc  cccggagat  gccgccgcc  120
tgggcttcc  ctccagcct  ctgaggacc  ggggctgcg  gagcgagca  aggcttaag  180
tcttcagcg  ggcgctcca  gaggcactc  cagagcact  caaacacca  tggtttccc  240
aaaagccgt  caagggctc  ggctaccgc  gcattcgca  caaccacaa  atggacccc  300
tcatcagca  ggtggccag  cagatcgga  tcagccagc  ccagctgca  cagctgctg  360
ccagcgagc  gaccctgtg  gtggacccc  atgaggtgt  ctaccgcat  ggggaggac  420
gctccatct  cgtcttgta  gaggaggcc  cactggccg  ctcctgtgg  ctcctcacc  480
gcaagaacc  agtgctgct  ggccggagc  gcccctcca  gaactacgt  atggcagtc  540
ccagctagg  ccttccgcc  ccgccctgg  cgccgccgt  ctcatgctg  cgtgacaac  600
ggccaccac  tacctcaac  tggggaact  tatttttaa  tgaagagct  tttatatat  660
ttatttttt  ttaagaaag  aggaaaaga  accaaaagt  ttttttaag  aaaaaaatc  720
ttcaaggga  ctgcttgga  gtggcctcc  caggtgcct  tggagagaa  tgttgcgtg  780
ttgagtctg  gagccagtg  ctgcctata  gagggggag  tgttagggg  tagacctag  840
caaggagaa  tgggagacg  ttggctagc  ccccaggaa  atgtgagag  gagcaagca  900
ggttagcaa  tgtgaacag  gaggtcggg  tttgccctg  gggaggaag  gaggccaag  960
tcagagctc  ctgtctccc  cagccagac  cctgcatcc  tggctcctc  attactcag  1020
ggcattcat  cctggactt  aacaatact  tgttatctt  tcttttatt  ttctaatga  1080
gtcctgggc  gagagtgaa  aggcctctc  tgattccta  tgtcctaag  tgcttttct  1140
gaaatcatg  cttgtttct  attctaccc  caggggcct  tagatgttg  tttccagcc  1200
ggaatctaa  gctttgggt  ttctgaggg  gggaggagg  aactggagg  tattggggt  1260
aggatggaa  ggaactctg  acaaaacct  tgctttgct  gtgctgctt  gtgtgtatg  1320
gtggcaaat  atttggggg  gatttgcaa  gaaattttg  gacccaaag  gtatccact  1380
gggatgttt  ttggccaaa  ctcttcctt  tggaaccac  tgaaagtct  gatgctgct  1440
ccatgatcc  tttgagagg  ggctcaaaa  ctacaggga  ctccaggtc  tttattact  1500
ccttctttt  aaaagcaca  ctctcctct  accctcccc  cccccttcc  ttctggtcg  1560
gtcatagag  taccgtatt  tctaggaca  gagttctca  tcactgtgc  atatgcccc  1620
tgggtccca  gagggtctg  aggaaaact  gctatcaga  cctcctgat  ccctggtgg  1680
cttagggaa  catctctcc  gctctcctt  ggatgatgg  tggctagtc  gccttgcat  1740
tattccttg  ctgaatggg  gagtgcccc  tgttctgca  gactacttg  tattcttgt  1800
gggccgaca  taaataaaa  ccaaacctt  ggcactgtt  tttctccct  gtgctcaga  1860
cacctgtgg  aaaggttgc  gtctgtctc  gtacaatcc  aatttgtcg  agacttgtg  1920
aatatatac  gttgtgggt  ggagaaaag  ggaaagcta  actgggaag  aactccctt  1980
cttcaattt  tcagtgaca  tgatgaggg  tcctcaaaa  acctcgagt  tcccaaacc  2040
aatcacctt  agaaggaca  ggctagggc  tttggccag  atggccacc  tcctgctgt  2100
gccccttag  gaggaatct  caccccact  cctctaccc  caggttctc  tccccacag  2160
cagtcccct  tcctggatt  ctaaactgc  caattttga  tcaaaggtg  tatttacca  2220
acactctcc  tacccattc  tgccagctc  gcctccttt  caactctcc  cattttgta  2280
tgccttccc  gacctgctt  cagtcttta  tgctttaaa  ttcactttg  gcccacaga  2340
ccaagagct  attttctgg  ttgtgggtt  aaacaaagc  gtgaatcac  gcaggctgt  2400
ttcttgcat  ttgtctgca  acaggtccc  gccttttta  aagcagcct  atggtctca  2460
gcttaatct  gtctctctt  tcttcttta  gatgttcac  ttaaaaaca  caaaacccc  2520
gagctggac  gttgagcag  cctgtctct  ctattaagt  aaaataaat  gtagtagta  2580
gtttgtaag  tattctgac  gaaaagaca  aggttacta  ttgtatgat  gtgttttta  2640
atggaagaa  gtacagctt  tggacaaat  tacaccttt  tgttacttt  ataaaaatg  2700
agtaggata  aaaaaaa  2717



<210> 3763
<211> 158
<212> PRT
<213> Homo sapiens
<308> P78543
<400> 3763

Met Ser His Gly Lys Gly Thr Asp Met Leu Pro Glu Ile Ala Ala Ala 
  1               5                  10                  15
Val Gly Phe Leu Ser Ser Leu Leu Arg Thr Arg Gly Cys Val Ser Glu 
             20                  25                  30
Gln Arg Leu Lys Val Phe Ser Gly Ala Leu Gln Glu Ala Leu Thr Glu 
         35                  40                  45
His Tyr Lys His His Trp Phe Pro Glu Lys Pro Ser Lys Gly Ser Gly 
     50                  55                  60
Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Ile Ile Ser Arg 
 65                  70                  75                  80
Val Ala Ser Gln Ile Gly Leu Ser Gln Pro Gln Leu His Gln Leu Leu 
                 85                  90                  95
Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser Tyr Arg 
             100                105                110
Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Glu Ala Pro Leu 
         115                120                125
Ala Ala Ser Cys Gly Leu Leu Thr Cys Lys Asn Gln Val Leu Leu Gly 
     130                135                140
Arg Ser Ser Pro Ser Lys Asn Tyr Val Met Ala Val Ser Ser 
 145                150                155



<210> 3764
<211> 2519
<212> DNA
<213> Rattus norvegicus
<308> M60921
<400> 3764

agagcccgt  aggcggccg  accatcatc  tcctgctaa  acagctact  cctcaacca  60
cggtatgag  cacgggaag  gaaccgaca  gctcccgga  atcgccgcc  ccgtaggtt  120
cctcaccag  ctcctgagg  ctcggggct  cgtgagcga  cagagactc  aggttttca  180
tagggcgct  caggacgca  tgaccgatc  ttacaaaca  cactggttt  cagaaaagc  240
atccaaggg  tccggctat  gctgtatcc  catcaacca  aagatggac  ccatcatca  300
caaggtggc  agccagatc  gactcagcc  gccccagct  caccagctc  tgcccagcg  360
gctgaccct  tgggtcgat  cctacgaag  gtcctaccg  atcggggaa  atggatcca  420
ctgcgtgct  tatgaggag  cgccggtgg  cacctccta  gggctcctc  cctgcaaga  480
ccagatgat  ctgggcagg  gcagtccat  gaagaacta  gtgatgact  tctccagct  540
gagaggagc  gccccgccc  ggcactcta  tgttctcat  ctgccctga  aacaggcca  600
cgtatacct  aacctgggg  actgtattt  taaagtgaa  agctattta  acatgttat  660
ttttttttt  agaaaagag  aggaaaaaa  ccaaaagtt  ttttttaaa  aaacaaaaa  720
gaaaaaaca  ttcgttaac  ggagctgct  ggaagtggt  tccccaggt  cctttggag  780
gaactgttc  tgattgagt  tatgagcca  tgtttgcct  ggggagtgg  ttggggatt  840
gcctagcca  ggtaaaagg  gattcttgg  tgatccccc  ggaggtggt  gaagggagc  900
aggttagca  ctgtgaacg  gaggggtca  ggtctgctc  gggttaccg  tcccgctgg  960
atgcctgta  tcctggtcc  tctcttact  aggggcatt  aagcctggt  tcaaataat  1020
ctacattgc  taatcttct  ttttgtttt  ctgctgaga  cctgggcac  cggaaaggc  1080
tctcctgtc  cttccgtct  agcagagtt  cttgaaact  tgtctcgtt  ctgatccta  1140
cctcggggt  ctgaagagg  ggtttcccg  cctagaatc  atctaaacg  ttttggagg  1200
tgggctata  ggcagatat  atggagggg  accgcacaa  ccctttgct  tgctctgtg  1260
tgctttgta  ggatggatg  ttaataact  agggatgat  tgcaatgga  ttttgggac  1320
caaagagta  ccaatgggg  tgggtgttt  ggacctaag  cctcctttt  ggaaccacg  1380
gacagtctg  atgctgcta  cattattcc  ttgagaggt  gctcaaagc  ccagggaac  1440
ccaggtcct  tcttactgc  ttctcttca  gagcaacct  ccccatttc  tttccctct  1500
tcctgcggt  gggtcctgg  gggccccat  tcctaggac  agagttctc  atcactgtg  1560
aatagtccc  ggaagctct  gaactgggc  tcccagccc  tcctgattc  tggtgggtt  1620
taggacccc  ccttccccg  tcttctgac  ggctggtgg  ccttgagga  atctccctc  1680
gccgcaggg  gggcacctg  gcactgcag  actacctgg  actcctgtg  ggctgccac  1740
gagagccaa  ccttaggca  agctttgtc  cctcggtgc  cagagcacc  gcaggggga  1800
gttgccccc  tcagtaaaa  tccaaattt  tttgtagat  tgtgcaata  ttactgttc  1860
gggttggag  aaatcggga  acactggga  gaagtggcc  tccttcagg  tcagtgaca  1920
tgatgaggg  ttctcagaa  gcctcgagt  tctcaaacc  aaggacaga  ctagagcca  1980
ccagtcacc  ttagtgagg  tccccttcc  catgtctct  cactgccgt  gcatcccat  2040
tcctggatt  ctcaattcc  cagtttcta  tcaaaggtg  tacttacca  acactctgc  2100
cgtcccgct  tccccagct  cgcacagcc  tcccaggtg  cttcgtctc  cctgcttta  2160
agttaactt  gggcccaca  acccgagag  tgtgggttg  agcaaagct  tgaatcgct  2220
cagatggtc  ctgtgttct  tccacacac  ggtccccgc  tttttagaa  cagcctcct  2280
gtctcatgc  taaatctgt  cctcactgc  cgtgttcac  ttagaaatg  cagaaccac  2340
gagctggac  gttgagcag  cctgtctct  tcattaaat  gaaataagt  agtttgtaa  2400
ctattccga  agaagagac  aaggttact  attgtacaa  agcgctttt  tatggaaga  2460
tgtacagct  tatggacaa  tgtaaaact  ttttgtttt  aataaaaat  tagcagacc  2519



<210> 3765
<211> 158
<212> PRT
<213> Rattus norvegicus
<308> P27049
<400> 3765

Met Ser His Gly Lys Arg Thr Asp Met Leu Pro Glu Ile Ala Ala Ala 
  1               5                  10                  15
Val Gly Phe Leu Thr Ser Leu Leu Arg Thr Arg Gly Cys Val Ser Glu 
             20                  25                  30
Gln Arg Leu Lys Val Phe Ser Arg Ala Leu Gln Asp Ala Leu Thr Asp 
         35                  40                  45
His Tyr Lys His His Trp Phe Pro Glu Lys Pro Ser Lys Gly Ser Gly 
     50                  55                  60
Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Ile Ile Ser Lys 
 65                  70                  75                  80
Val Ala Ser Gln Ile Gly Leu Ser Gln Pro Gln Leu His Gln Leu Leu 
                 85                  90                  95
Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser Tyr Arg 
             100                105                110
Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Glu Ala Pro Val 
         115                120                125
Ala Thr Ser Tyr Gly Leu Leu Thr Cys Lys Asn Gln Met Met Leu Gly 
     130                135                140
Arg Ser Ser Pro Ser Lys Asn Tyr Val Met Thr Val Ser Ser 
 145                150                155



<210> 3766
<211> 2717
<212> DNA
<213> Homo sapiens
<308> U72649
<400> 3766

cagggtaac  ctgtcttgt  gacccgcac  tcccacccg  gacctctca  tgagcccga  60
ccgcgcgcg  catgagcca  gggaaggga  ccgacatgc  cccggagat  gccgccgcc  120
tgggcttcc  ctccagcct  ctgaggacc  ggggctgcg  gagcgagca  aggcttaag  180
tcttcagcg  ggcgctcca  gaggcactc  cagagcact  caaacacca  tggtttccc  240
aaaagccgt  caagggctc  ggctaccgc  gcattcgca  caaccacaa  atggacccc  300
tcatcagca  ggtggccag  cagatcgga  tcagccagc  ccagctgca  cagctgctg  360
ccagcgagc  gaccctgtg  gtggacccc  atgaggtgt  ctaccgcat  ggggaggac  420
gctccatct  cgtcttgta  gaggaggcc  cactggccg  ctcctgtgg  ctcctcacc  480
gcaagaacc  agtgctgct  ggccggagc  gcccctcca  gaactacgt  atggcagtc  540
ccagctagg  ccttccgcc  ccgccctgg  cgccgccgt  ctcatgctg  cgtgacaac  600
ggccaccac  tacctcaac  tggggaact  tatttttaa  tgaagagct  tttatatat  660
ttatttttt  ttaagaaag  aggaaaaga  accaaaagt  ttttttaag  aaaaaaatc  720
ttcaaggga  ctgcttgga  gtggcctcc  caggtgcct  tggagagaa  tgttgcgtg  780
ttgagtctg  gagccagtg  ctgcctata  gagggggag  tgttagggg  tagacctag  840
caaggagaa  tgggagacg  ttggctagc  ccccaggaa  atgtgagag  gagcaagca  900
ggttagcaa  tgtgaacag  gaggtcggg  tttgccctg  gggaggaag  gaggccaag  960
tcagagctc  ctgtctccc  cagccagac  cctgcatcc  tggctcctc  attactcag  1020
ggcattcat  cctggactt  aacaatact  tgttatctt  tcttttatt  ttctaatga  1080
gtcctgggc  gagagtgaa  aggcctctc  tgattccta  tgtcctaag  tgcttttct  1140
gaaatcatg  cttgtttct  attctaccc  caggggcct  tagatgttg  tttccagcc  1200
ggaatctaa  gctttgggt  ttctgaggg  gggaggagg  aactggagg  tattggggt  1260
aggatggaa  ggaactctg  acaaaacct  tgctttgct  gtgctgctt  gtgtgtatg  1320
gtggcaaat  atttggggg  gatttgcaa  gaaattttg  gacccaaag  gtatccact  1380
gggatgttt  ttggccaaa  ctcttcctt  tggaaccac  tgaaagtct  gatgctgct  1440
ccatgatcc  tttgagagg  ggctcaaaa  ctacaggga  ctccaggtc  tttattact  1500
ccttctttt  aaaagcaca  ctctcctct  accctcccc  cccccttcc  ttctggtcg  1560
gtcatagag  taccgtatt  tctaggaca  gagttctca  tcactgtgc  atatgcccc  1620
tgggtccca  gagggtctg  aggaaaact  gctatcaga  cctcctgat  ccctggtgg  1680
cttagggaa  catctctcc  gctctcctt  ggatgatgg  tggctagtc  gccttgcat  1740
tattccttg  ctgaatggg  gagtgcccc  tgttctgca  gactacttg  tattcttgt  1800
gggccgaca  taaataaaa  ccaaacctt  ggcactgtt  tttctccct  gtgctcaga  1860
cacctgtgg  aaaggttgc  gtctgtctc  gtacaatcc  aatttgtcg  agacttgtg  1920
aatatatac  gttgtgggt  ggagaaaag  ggaaagcta  actgggaag  aactccctt  1980
cttcaattt  tcagtgaca  tgatgaggg  tcctcaaaa  acctcgagt  tcccaaacc  2040
aatcacctt  agaaggaca  ggctagggc  tttggccag  atggccacc  tcctgctgt  2100
gccccttag  gaggaatct  caccccact  cctctaccc  caggttctc  tccccacag  2160
cagtcccct  tcctggatt  ctaaactgc  caattttga  tcaaaggtg  tatttacca  2220
acactctcc  tacccattc  tgccagctc  gcctccttt  caactctcc  cattttgta  2280
tgccttccc  gacctgctt  cagtcttta  tgctttaaa  ttcactttg  gcccacaga  2340
ccaagagct  attttctgg  ttgtgggtt  aaacaaagc  gtgaatcac  gcaggctgt  2400
ttcttgcat  ttgtctgca  acaggtccc  gccttttta  aagcagcct  atggtctca  2460
gcttaatct  gtctctctt  tcttcttta  gatgttcac  ttaaaaaca  caaaacccc  2520
gagctggac  gttgagcag  cctgtctct  ctattaagt  aaaataaat  gtagtagta  2580
gtttgtaag  tattctgac  gaaaagaca  aggttacta  ttgtatgat  gtgttttta  2640
atggaagaa  gtacagctt  tggacaaat  tacaccttt  tgttacttt  ataaaaatg  2700
agtaggata  aaaaaaa  2717



<210> 3767
<211> 158
<212> PRT
<213> Homo sapiens
<308> P78543
<400> 3767

Met Ser His Gly Lys Gly Thr Asp Met Leu Pro Glu Ile Ala Ala Ala 
  1               5                  10                  15
Val Gly Phe Leu Ser Ser Leu Leu Arg Thr Arg Gly Cys Val Ser Glu 
             20                  25                  30
Gln Arg Leu Lys Val Phe Ser Gly Ala Leu Gln Glu Ala Leu Thr Glu 
         35                  40                  45
His Tyr Lys His His Trp Phe Pro Glu Lys Pro Ser Lys Gly Ser Gly 
     50                  55                  60
Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Ile Ile Ser Arg 
 65                  70                  75                  80
Val Ala Ser Gln Ile Gly Leu Ser Gln Pro Gln Leu His Gln Leu Leu 
                 85                  90                  95
Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser Tyr Arg 
             100                105                110
Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Glu Ala Pro Leu 
         115                120                125
Ala Ala Ser Cys Gly Leu Leu Thr Cys Lys Asn Gln Val Leu Leu Gly 
     130                135                140
Arg Ser Ser Pro Ser Lys Asn Tyr Val Met Ala Val Ser Ser 
 145                150                155



<210> 3768
<211> 2519
<212> DNA
<213> Rattus norvegicus
<308> M60921
<400> 3768

agagcccgt  aggcggccg  accatcatc  tcctgctaa  acagctact  cctcaacca  60
cggtatgag  cacgggaag  gaaccgaca  gctcccgga  atcgccgcc  ccgtaggtt  120
cctcaccag  ctcctgagg  ctcggggct  cgtgagcga  cagagactc  aggttttca  180
tagggcgct  caggacgca  tgaccgatc  ttacaaaca  cactggttt  cagaaaagc  240
atccaaggg  tccggctat  gctgtatcc  catcaacca  aagatggac  ccatcatca  300
caaggtggc  agccagatc  gactcagcc  gccccagct  caccagctc  tgcccagcg  360
gctgaccct  tgggtcgat  cctacgaag  gtcctaccg  atcggggaa  atggatcca  420
ctgcgtgct  tatgaggag  cgccggtgg  cacctccta  gggctcctc  cctgcaaga  480
ccagatgat  ctgggcagg  gcagtccat  gaagaacta  gtgatgact  tctccagct  540
gagaggagc  gccccgccc  ggcactcta  tgttctcat  ctgccctga  aacaggcca  600
cgtatacct  aacctgggg  actgtattt  taaagtgaa  agctattta  acatgttat  660
ttttttttt  agaaaagag  aggaaaaaa  ccaaaagtt  ttttttaaa  aaacaaaaa  720
gaaaaaaca  ttcgttaac  ggagctgct  ggaagtggt  tccccaggt  cctttggag  780
gaactgttc  tgattgagt  tatgagcca  tgtttgcct  ggggagtgg  ttggggatt  840
gcctagcca  ggtaaaagg  gattcttgg  tgatccccc  ggaggtggt  gaagggagc  900
aggttagca  ctgtgaacg  gaggggtca  ggtctgctc  gggttaccg  tcccgctgg  960
atgcctgta  tcctggtcc  tctcttact  aggggcatt  aagcctggt  tcaaataat  1020
ctacattgc  taatcttct  ttttgtttt  ctgctgaga  cctgggcac  cggaaaggc  1080
tctcctgtc  cttccgtct  agcagagtt  cttgaaact  tgtctcgtt  ctgatccta  1140
cctcggggt  ctgaagagg  ggtttcccg  cctagaatc  atctaaacg  ttttggagg  1200
tgggctata  ggcagatat  atggagggg  accgcacaa  ccctttgct  tgctctgtg  1260
tgctttgta  ggatggatg  ttaataact  agggatgat  tgcaatgga  ttttgggac  1320
caaagagta  ccaatgggg  tgggtgttt  ggacctaag  cctcctttt  ggaaccacg  1380
gacagtctg  atgctgcta  cattattcc  ttgagaggt  gctcaaagc  ccagggaac  1440
ccaggtcct  tcttactgc  ttctcttca  gagcaacct  ccccatttc  tttccctct  1500
tcctgcggt  gggtcctgg  gggccccat  tcctaggac  agagttctc  atcactgtg  1560
aatagtccc  ggaagctct  gaactgggc  tcccagccc  tcctgattc  tggtgggtt  1620
taggacccc  ccttccccg  tcttctgac  ggctggtgg  ccttgagga  atctccctc  1680
gccgcaggg  gggcacctg  gcactgcag  actacctgg  actcctgtg  ggctgccac  1740
gagagccaa  ccttaggca  agctttgtc  cctcggtgc  cagagcacc  gcaggggga  1800
gttgccccc  tcagtaaaa  tccaaattt  tttgtagat  tgtgcaata  ttactgttc  1860
gggttggag  aaatcggga  acactggga  gaagtggcc  tccttcagg  tcagtgaca  1920
tgatgaggg  ttctcagaa  gcctcgagt  tctcaaacc  aaggacaga  ctagagcca  1980
ccagtcacc  ttagtgagg  tccccttcc  catgtctct  cactgccgt  gcatcccat  2040
tcctggatt  ctcaattcc  cagtttcta  tcaaaggtg  tacttacca  acactctgc  2100
cgtcccgct  tccccagct  cgcacagcc  tcccaggtg  cttcgtctc  cctgcttta  2160
agttaactt  gggcccaca  acccgagag  tgtgggttg  agcaaagct  tgaatcgct  2220
cagatggtc  ctgtgttct  tccacacac  ggtccccgc  tttttagaa  cagcctcct  2280
gtctcatgc  taaatctgt  cctcactgc  cgtgttcac  ttagaaatg  cagaaccac  2340
gagctggac  gttgagcag  cctgtctct  tcattaaat  gaaataagt  agtttgtaa  2400
ctattccga  agaagagac  aaggttact  attgtacaa  agcgctttt  tatggaaga  2460
tgtacagct  tatggacaa  tgtaaaact  ttttgtttt  aataaaaat  tagcagacc  2519



<210> 3769
<211> 158
<212> PRT
<213> Rattus norvegicus
<308> P27049
<400> 3769

Met Ser His Gly Lys Arg Thr Asp Met Leu Pro Glu Ile Ala Ala Ala 
  1               5                  10                  15
Val Gly Phe Leu Thr Ser Leu Leu Arg Thr Arg Gly Cys Val Ser Glu 
             20                  25                  30
Gln Arg Leu Lys Val Phe Ser Arg Ala Leu Gln Asp Ala Leu Thr Asp 
         35                  40                  45
His Tyr Lys His His Trp Phe Pro Glu Lys Pro Ser Lys Gly Ser Gly 
     50                  55                  60
Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Ile Ile Ser Lys 
 65                  70                  75                  80
Val Ala Ser Gln Ile Gly Leu Ser Gln Pro Gln Leu His Gln Leu Leu 
                 85                  90                  95
Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser Tyr Arg 
             100                105                110
Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Glu Ala Pro Val 
         115                120                125
Ala Thr Ser Tyr Gly Leu Leu Thr Cys Lys Asn Gln Met Met Leu Gly 
     130                135                140
Arg Ser Ser Pro Ser Lys Asn Tyr Val Met Thr Val Ser Ser 
 145                150                155



<210> 3770
<211> 2717
<212> DNA
<213> Homo sapiens
<308> U72649
<400> 3770

cagggtaac  ctgtcttgt  gacccgcac  tcccacccg  gacctctca  tgagcccga  60
ccgcgcgcg  catgagcca  gggaaggga  ccgacatgc  cccggagat  gccgccgcc  120
tgggcttcc  ctccagcct  ctgaggacc  ggggctgcg  gagcgagca  aggcttaag  180
tcttcagcg  ggcgctcca  gaggcactc  cagagcact  caaacacca  tggtttccc  240
aaaagccgt  caagggctc  ggctaccgc  gcattcgca  caaccacaa  atggacccc  300
tcatcagca  ggtggccag  cagatcgga  tcagccagc  ccagctgca  cagctgctg  360
ccagcgagc  gaccctgtg  gtggacccc  atgaggtgt  ctaccgcat  ggggaggac  420
gctccatct  cgtcttgta  gaggaggcc  cactggccg  ctcctgtgg  ctcctcacc  480
gcaagaacc  agtgctgct  ggccggagc  gcccctcca  gaactacgt  atggcagtc  540
ccagctagg  ccttccgcc  ccgccctgg  cgccgccgt  ctcatgctg  cgtgacaac  600
ggccaccac  tacctcaac  tggggaact  tatttttaa  tgaagagct  tttatatat  660
ttatttttt  ttaagaaag  aggaaaaga  accaaaagt  ttttttaag  aaaaaaatc  720
ttcaaggga  ctgcttgga  gtggcctcc  caggtgcct  tggagagaa  tgttgcgtg  780
ttgagtctg  gagccagtg  ctgcctata  gagggggag  tgttagggg  tagacctag  840
caaggagaa  tgggagacg  ttggctagc  ccccaggaa  atgtgagag  gagcaagca  900
ggttagcaa  tgtgaacag  gaggtcggg  tttgccctg  gggaggaag  gaggccaag  960
tcagagctc  ctgtctccc  cagccagac  cctgcatcc  tggctcctc  attactcag  1020
ggcattcat  cctggactt  aacaatact  tgttatctt  tcttttatt  ttctaatga  1080
gtcctgggc  gagagtgaa  aggcctctc  tgattccta  tgtcctaag  tgcttttct  1140
gaaatcatg  cttgtttct  attctaccc  caggggcct  tagatgttg  tttccagcc  1200
ggaatctaa  gctttgggt  ttctgaggg  gggaggagg  aactggagg  tattggggt  1260
aggatggaa  ggaactctg  acaaaacct  tgctttgct  gtgctgctt  gtgtgtatg  1320
gtggcaaat  atttggggg  gatttgcaa  gaaattttg  gacccaaag  gtatccact  1380
gggatgttt  ttggccaaa  ctcttcctt  tggaaccac  tgaaagtct  gatgctgct  1440
ccatgatcc  tttgagagg  ggctcaaaa  ctacaggga  ctccaggtc  tttattact  1500
ccttctttt  aaaagcaca  ctctcctct  accctcccc  cccccttcc  ttctggtcg  1560
gtcatagag  taccgtatt  tctaggaca  gagttctca  tcactgtgc  atatgcccc  1620
tgggtccca  gagggtctg  aggaaaact  gctatcaga  cctcctgat  ccctggtgg  1680
cttagggaa  catctctcc  gctctcctt  ggatgatgg  tggctagtc  gccttgcat  1740
tattccttg  ctgaatggg  gagtgcccc  tgttctgca  gactacttg  tattcttgt  1800
gggccgaca  taaataaaa  ccaaacctt  ggcactgtt  tttctccct  gtgctcaga  1860
cacctgtgg  aaaggttgc  gtctgtctc  gtacaatcc  aatttgtcg  agacttgtg  1920
aatatatac  gttgtgggt  ggagaaaag  ggaaagcta  actgggaag  aactccctt  1980
cttcaattt  tcagtgaca  tgatgaggg  tcctcaaaa  acctcgagt  tcccaaacc  2040
aatcacctt  agaaggaca  ggctagggc  tttggccag  atggccacc  tcctgctgt  2100
gccccttag  gaggaatct  caccccact  cctctaccc  caggttctc  tccccacag  2160
cagtcccct  tcctggatt  ctaaactgc  caattttga  tcaaaggtg  tatttacca  2220
acactctcc  tacccattc  tgccagctc  gcctccttt  caactctcc  cattttgta  2280
tgccttccc  gacctgctt  cagtcttta  tgctttaaa  ttcactttg  gcccacaga  2340
ccaagagct  attttctgg  ttgtgggtt  aaacaaagc  gtgaatcac  gcaggctgt  2400
ttcttgcat  ttgtctgca  acaggtccc  gccttttta  aagcagcct  atggtctca  2460
gcttaatct  gtctctctt  tcttcttta  gatgttcac  ttaaaaaca  caaaacccc  2520
gagctggac  gttgagcag  cctgtctct  ctattaagt  aaaataaat  gtagtagta  2580
gtttgtaag  tattctgac  gaaaagaca  aggttacta  ttgtatgat  gtgttttta  2640
atggaagaa  gtacagctt  tggacaaat  tacaccttt  tgttacttt  ataaaaatg  2700
agtaggata  aaaaaaa  2717



<210> 3771
<211> 158
<212> PRT
<213> Homo sapiens
<308> P78543
<400> 3771

Met Ser His Gly Lys Gly Thr Asp Met Leu Pro Glu Ile Ala Ala Ala 
  1               5                  10                  15
Val Gly Phe Leu Ser Ser Leu Leu Arg Thr Arg Gly Cys Val Ser Glu 
             20                  25                  30
Gln Arg Leu Lys Val Phe Ser Gly Ala Leu Gln Glu Ala Leu Thr Glu 
         35                  40                  45
His Tyr Lys His His Trp Phe Pro Glu Lys Pro Ser Lys Gly Ser Gly 
     50                  55                  60
Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Ile Ile Ser Arg 
 65                  70                  75                  80
Val Ala Ser Gln Ile Gly Leu Ser Gln Pro Gln Leu His Gln Leu Leu 
                 85                  90                  95
Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser Tyr Arg 
             100                105                110
Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Glu Ala Pro Leu 
         115                120                125
Ala Ala Ser Cys Gly Leu Leu Thr Cys Lys Asn Gln Val Leu Leu Gly 
     130                135                140
Arg Ser Ser Pro Ser Lys Asn Tyr Val Met Ala Val Ser Ser 
 145                150                155



<210> 3772
<211> 1688
<212> DNA
<213> Rattus norvegicus
<308> M61219
<400> 3772

cagaaggag  catggctgc  aaagtgttt  agtccatcg  aaagttcgg  ctggcctta  60
cagttgcag  aggcgtggt  aactctgct  tatataacg  ggatgccgg  cacagagct  120
tcatcttcg  ccgattccg  ggcgtgcag  acatcgtgg  aggggaagg  actcacttc  180
tcatcccct  ggtacagaa  ccaatcatc  ttgactgcc  ctctcgacc  cgtaatgtg  240
cggtcatca  cggcagcaa  gacttgcag  atgtcaaca  cacactacg  atcctcttc  300
ggccggtgg  cagccagct  cctcgtatc  acaccagca  tggcgagga  tatgatgag  360
gggtgctgc  atctatcac  acagagatc  tcaagtcgg  ggtggctcg  ttcgatgct  420
gagaattga  tacccagcg  gagctggtc  ccaggcagg  gagtgatga  ctcacagag  480
gagcagcaa  attcgggct  atcctggat  acgtgtccc  gacacatct  accttcggg  540
aggagttca  agaggcggt  gaagccaaa  aggtggctc  gcaggaagc  gagagagcc  600
gatttgtgg  ggaaaaggc  gagcagcag  agaaggcgg  catcatctc  gctgagggt  660
actccaaag  ggctgagct  atcgccaac  cactggcca  cgccgggga  ggcctgatc  720
agctgcgaa  gctggaagc  gctgaggac  ttgcttatc  gctctcccg  tctcggaac  780
tcacctacc  gccagcagg  cagtccgtg  tcctccagc  cccccagta  ggccagcca  840
ccagggcct  catcgctct  aatgacgcc  tccttctgc  ccaccccag  aatcactgt  900
aaatttaat  attggctta  catgaagga  ataaaggta  aatcacttc  tatctctaa  960
tatcaaatg  agcttttat  gttacactt  ttgcccact  tcataacaa  attgccaag  1020
gcctatgca  actggcctt  caccctggg  gctggcagt  ggcggaaga  aggcagggc  1080
gtgtgtgtg  tggacgggg  gccagctgg  agcctgagt  gaccttgag  ctccattct  1140
ccatatatt  aagatttac  gacagtggt  cacacacgt  aaccaaaag  aagccctca  1200
tttttccag  catacgaac  cggacagat  cagctgagg  gggcctgag  aagtggtct  1260
tcttaactg  aaggccatt  cctcttaac  gtgaccagc  gaagcaggt  tgtgcgtgc  1320
actagggca  ggagtgaag  atctgccca  cacggtggg  gggcctaat  ttgctgccc  1380
caccagaga  ctaaacttt  gatagactt  gatagaata  gaggcctgg  ctgagatgt  1440
agtcctgtg  aagacttcc  gtccacccc  cacattggt  ctctcaaat  ccaatggga  1500
tccagcttg  aggattgca  ctgccgggg  tgagcacac  tgccaagga  acgtgcgcc  1560
gccttcccg  tccctctct  cgagattgc  cttccttcc  aagggctgt  ggccagagc  1620
ccgaaggaa  caatcaagg  aagaaaaca  aatgtaagc  gctgtcaat  aatgacacc  1680
agaccctc  1688



<210> 3773
<211> 272
<212> PRT
<213> Rattus norvegicus
<308> P24142
<400> 3773

Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu 
  1               5                  10                  15
Ala Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Asn Val Asp Ala 
             20                  25                  30
Gly His Arg Ala Val Ile Phe Asp Arg Phe Arg Gly Val Gln Asp Ile 
         35                  40                  45
Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln Lys Pro 
     50                  55                  60
Ile Ile Phe Asp Cys Arg Ser Arg Pro Arg Asn Val Pro Val Ile Thr 
 65                  70                  75                  80
Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Arg Ile Leu Phe 
                 85                  90                  95
Arg Pro Val Ala Ser Gln Leu Pro Arg Ile Tyr Thr Ser Ile Gly Glu 
             100                105                110
Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr Glu Ile Leu Lys 
         115                120                125
Ser Val Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu 
     130                135                140
Leu Val Ser Arg Gln Val Ser Asp Asp Leu Thr Glu Arg Ala Ala Thr 
 145                150                155                160
Phe Gly Leu Ile Leu Asp Asp Val Ser Leu Thr His Leu Thr Phe Gly 
                 165                170                175
Lys Glu Phe Thr Glu Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu 
             180                185                190
Ala Glu Arg Ala Arg Phe Val Val Glu Lys Ala Glu Gln Gln Lys Lys 
         195                200                205
Ala Ala Ile Ile Ser Ala Glu Gly Asp Ser Lys Ala Ala Glu Leu Ile 
     210                215                220
Ala Asn Ser Leu Ala Thr Ala Gly Asp Gly Leu Ile Glu Leu Arg Lys 
 225                230                235                240
Leu Glu Ala Ala Glu Asp Ile Ala Tyr Gln Leu Ser Arg Ser Arg Asn 
                 245                250                255
Ile Thr Tyr Leu Pro Ala Gly Gln Ser Val Leu Leu Gln Leu Pro Gln 
             260                265                270



<210> 3774
<211> 1826
<212> DNA
<213> Homo sapiens
<308> NM_002634
<400> 3774

agtatgtgt  gttggggaa  tcatgtgga  gtcagagtg  aagcaggtg  gagagggtc  60
agcagaagg  aacatggct  ccaaagtgt  tgagtccat  ggcaagttt  gcctggcct  120
agctgttgc  ggaggcgtg  tgaactctg  cttatataa  gtggatgct  ggcacagag  180
tgtcatctt  gaccgattc  gtggagtgc  ggacattgt  gtaggggaa  ggactcatt  240
tctcatccc  tgggtacag  aaccaatta  ctttgactg  cgttctcga  cacgtaatg  300
gccagtcat  actggtagc  aagatttac  gaatgtcaa  atcacactg  gcatcctct  360
ccggcctgt  gccagccag  ttcctcgca  cttcaccag  atcggagag  actatgatg  420
gcgtgtgct  ccgtccatc  caactgaga  cctcaagtc  gtggtggct  gctttgatg  480
tggagaact  atcacccag  gagagctgg  ctccaggca  gtgagcgac  accttacag  540
gcgagccgc  acctttggg  tcatcctgg  tgacgtgtc  ttgacacat  tgaccttcg  600
gaaggagtt  acagaagcg  tggaagcca  acaggtggc  cagcaggaa  cagagaggg  660
cagatttgt  gtggaaaag  ctgagcaac  gaaaaaggc  gccatcatc  ctgctgagg  720
cgactccaa  gcagctgag  tgattgcca  ctcactggc  actgcaggg  atggcctga  780
cgagctgcg  aagctggaa  ctgcagagg  catcgcgta  cagctctca  gctctcgga  840
catcaccta  ctgccagcg  ggcagtccg  gctcctcca  ctgccccag  gagggccca  900
cctgcctgc  cctccgcgg  ctgactggg  cacagcccc  atgattctt  acacagcct  960
ccttctgct  ccaccccag  aatcactgt  aaatttcat  attggctta  agtgaagga  1020
ataaaggta  aatcacttc  gatctctaa  tagtctatc  aatgaaact  tttcattct  1080
ctcacatcc  tctactttt  tatccacct  cctaccaaa  attgccaag  gcctatgca  1140
accagcttt  ggtcccaat  cggggcctg  tggagttcc  gcctgggca  cagcatttg  1200
cagcacgca  gcggggcag  atgtgatgg  ctggggagc  caggtgtct  cctagatcc  1260
cgtgtggcc  ccgtcctgt  actgatgga  ggtttgcgg  tgagggcat  tgcggctga  1320
ctgagaagg  aggcctccg  cttcccagc  gttcctgtg  agatgctgc  gaagagagg  1380
gccggggag  ggcagagag  aagtggtct  tctgttacc  taagtctga  tctctttaa  1440
tgtgtgacc  gcggaaaca  gtgtgtgtg  actgggcac  gattgaaga  tctgcccct  1500
ttgaggtgg  tgggcctga  tgttgcccc  cagggtcct  aaacttgga  ggacttgta  1560
agtgagaga  gaggcctgg  ccgagatgt  agtcctgtt  aagacttcc  ctctacccc  1620
caccttggt  cctctcaga  acccagtgg  attccaact  gaaggattg  atcctgctg  1680
ggctgaaca  gcctgccaa  gacgtgtcc  acctacgtt  ctggccccc  cgttcagag  1740
ctgcccttc  cacgggctc  atgcctgca  tgggaagga  acaaatgtg  ataaactgc  1800
gtcaataaa  gacacccag  ccttcc  1826



<210> 3775
<211> 272
<212> PRT
<213> Homo sapiens
<308> P35232
<400> 3775

Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu 
  1               5                  10                  15
Ala Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Asn Val Asp Ala 
             20                  25                  30
Gly His Arg Ala Val Ile Phe Asp Arg Phe Arg Gly Val Gln Asp Ile 
         35                  40                  45
Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln Lys Pro 
     50                  55                  60
Ile Ile Phe Asp Cys Arg Ser Arg Pro Arg Asn Val Pro Val Ile Thr 
 65                  70                  75                  80
Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Arg Ile Leu Phe 
                 85                  90                  95
Arg Pro Val Ala Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu 
             100                105                110
Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr Glu Ile Leu Lys 
         115                120                125
Ser Val Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu 
     130                135                140
Leu Val Ser Arg Gln Val Ser Asp Asp Leu Thr Glu Arg Ala Ala Thr 
 145                150                155                160
Phe Gly Leu Ile Leu Asp Asp Val Ser Leu Thr His Leu Thr Phe Gly 
                 165                170                175
Lys Glu Phe Thr Glu Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu 
             180                185                190
Ala Glu Arg Ala Arg Phe Val Val Glu Lys Ala Glu Gln Gln Lys Lys 
         195                200                205
Ala Ala Ile Ile Ser Ala Glu Gly Asp Ser Lys Ala Ala Glu Leu Ile 
     210                215                220
Ala Asn Ser Leu Ala Thr Ala Gly Asp Gly Leu Ile Glu Leu Arg Lys 
 225                230                235                240
Leu Glu Ala Ala Glu Asp Ile Ala Tyr Gln Leu Ser Arg Ser Arg Asn 
                 245                250                255
Ile Thr Tyr Leu Pro Ala Gly Gln Ser Val Leu Leu Gln Leu Pro Gln 
             260                265                270



<210> 3776
<211> 2747
<212> DNA
<213> Rattus norvegicus
<308> M61875
<400> 3776

ctcattgcc  agcagcccc  agccagtga  aggttccat  caccctctt  gccccttcc  60
ccgcgaccc  tttccagag  ctactagat  ctttggttt  atcctgcac  tcatggaca  120
ggtttggtg  cacacagct  ggggactac  ttgcctctt  cagttgagc  tggcacagc  180
gcagatcga  ttgaatata  cctgccgtt  cgcaggtgt  ttccatgtg  agaaaaatg  240
ccgctacag  atctccagg  ctgaagcag  tgacctctg  gaggctttc  acaccacct  300
gcccaccat  gctcagatg  agttagccc  gagaaaggg  tttgaaaca  gcaggtatg  360
gttcataga  ggacacgtg  taatcccga  gatccaccc  aacgctatc  gtgcagcca  420
caacacagg  gtgtatatc  tcctcgcat  caacacctc  cactatgac  catattgct  480
caatgcctc  gctcctctt  aagaagact  tacatcagt  acagaccta  ccaattcct  540
cgatggacc  gttaccata  ctattgtca  ccgtgatgg  acccgctac  gcaagaagg  600
cgagtatag  acacaccaa  aagacatcg  tgcctcaaa  attatagat  aggatgtca  660
cagtggatc  accattgag  agagcaccc  agaaggcta  attttgcac  ccgaccttc  720
cacttcaca  cctactgga  accgggatg  cgccttctt  attgggagc  ccctggcca  780
cagtgatgg  gactcatcc  tggacccca  gggtggttt  gacactgtg  ctcatggat  840
cgaattagc  ggacactca  gtgggaatc  agacagtgg  gtgaccaca  cttctggtc  900
tgcgaggag  cctcagatt  cagagtggc  tatcatctt  gcatccctc  tggcgctgg  960
tctgattct  gccgtctgc  ttgctgtca  cagtaggag  aggtgtggg  agaagaaga  1020
gctggtgat  aacagtggc  atggaacag  ggaagacag  aaaccaagt  aactcaacg  1080
ggaggccag  aagtctcag  aaatggtgc  tttggtgaa  aaggaacca  cagagactc  1140
ggaccagtt  atgacagct  atgagaccc  gaatctgca  agtgtggat  tgaagattg  1200
ggtgtagtg  ctatgccac  aacttgaaa  gacacaaca  ttggagaca  gtcattact  1260
ggagctggg  cccttaaca  atgcaatgt  ctactgatt  ttttttatt  ggattattt  1320
gggcataaa  tttcccttt  tttgttttt  aaaagtttg  tttccaatt  atgaaaata  1380
cattgcttt  tgaaatgag  gtctcttcc  gttcctcct  agaggcctt  cattaccag  1440
gtatgctac  ataggcttc  accaaatga  tactcttgg  cccgattga  cccaaagtc  1500
caggtaaca  ccaccagct  aggatttcc  cagaactta  agagattgg  ctctgggag  1560
aaatttgaa  gggtccata  tgcctccca  cagtccaat  tgtaggcat  gctttgcag  1620
ggatgggag  tcaggtgta  tggttacac  ctctcttta  agactccct  ctgctggaa  1680
atttccaca  gcttctgag  gattcccca  aggtgacgc  atttatctt  agtaagcta  1740
ttatctttg  ttttgaaat  tcaaaccct  gaggtcctt  tttcagtat  acttttttt  1800
ttttgtttt  ttttatttt  ttttttagg  tactttgtc  gaagcataa  agggtataa  1860
ttgattcat  ataaatacc  gtccatctt  catcttgac  tgttgtgct  tgatccttc  1920
gtttctaaa  cagcaaggt  tgagtcttt  tagcacatc  atgtgacct  agtatggtc  1980
tctgaaact  atgttagag  atccgtgcc  tgcttgggt  tacccagct  aatctcaga  2040
gatcaagga  aggagcact  ttttcattc  aggactatc  aaggggttt  tctcctgtt  2100
aagaatctg  attgggagt  ggagagctt  tgtcccttt  atgtttcga  aaccaccca  2160
ttctctttc  taaagggca  attaagttt  tatatctta  aacattcgc  gtcctgttt  2220
atagacact  atcttattg  cactttcac  aaacagtgt  gaggggact  ctgacacct  2280
atagtaaaa  gagaagcca  cagaaatga  agtgtggac  gagagcagt  gattggcat  2340
aggaggcat  atgtacaac  cccagacca  tctttccat  accacattt  ttgatgctt  2400
cgcaagcca  ttggtactt  gaatcagtt  cccagggaa  ccttcaaaa  gccataaga  2460
tgcccaccc  tggaatctt  ccaccacca  atgagcagg  ttatggttt  gcaaaagga  2520
aatgctgtc  ccctctgac  tcatagttt  cacatactg  gcaagtgtt  atctgccag  2580
atgccccat  gctcctagg  cttcccagg  accttgtag  agaacttaa  tctataaaa  2640
aaggctttc  ctaaaatgg  acttccttt  taaggctcc  atttttact  ttgactaaa  2700
ttatatgtt  aatagtttt  tttcaaata  aaacaaaca  aaaaagg  2747



<210> 3777
<211> 503
<212> PRT
<213> Rattus norvegicus
<308> P26051
<400> 3777

Met Asp Lys Val Trp Trp His Thr Ala Trp Gly Leu Leu Cys Leu Leu 
  1               5                  10                  15
Gln Leu Ser Leu Ala Gln Gln Gln Ile Asp Leu Asn Ile Thr Cys Arg 
             20                  25                  30
Tyr Ala Gly Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser 
         35                  40                  45
Arg Thr Glu Ala Ala Asp Leu Cys Glu Ala Phe Asn Thr Thr Leu Pro 
     50                  55                  60
Thr Met Ala Gln Met Glu Leu Ala Leu Arg Lys Gly Phe Glu Thr Cys 
 65                  70                  75                  80
Arg Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro 
                 85                  90                  95
Asn Ala Ile Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Leu Ala 
             100                105                110
Ser Asn Thr Ser His Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro 
         115                120                125
Leu Glu Glu Asp Cys Thr Ser Val Thr Asp Leu Pro Asn Ser Phe Asp 
     130                135                140
Gly Pro Val Thr Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Ser 
 145                150                155                160
Lys Lys Gly Glu Tyr Arg Thr His Gln Glu Asp Ile Asp Ala Ser Asn 
                 165                170                175
Ile Ile Asp Glu Asp Val Ser Ser Gly Ser Thr Ile Glu Lys Ser Thr 
             180                185                190
Pro Glu Gly Tyr Ile Leu His Thr Asp Leu Pro Thr Ser Gln Pro Thr 
         195                200                205
Gly Asp Arg Asp Asp Ala Phe Phe Ile Gly Ser Thr Leu Ala Thr Ile 
     210                215                220
Ala Thr Thr Pro Trp Val Ser Ala His Thr Lys Gln Asn Gln Glu Arg 
 225                230                235                240
Thr Gln Trp Asn Pro Ile His Ser Asn Pro Glu Val Leu Leu Gln Thr 
                 245                250                255
Thr Thr Arg Met Thr Asp Ile Asp Arg Asn Ser Thr Ser Ala His Gly 
             260                265                270
Glu Asn Trp Thr Gln Glu Pro Gln Pro Pro Phe Asn Asn His Glu Tyr 
         275                280                285
Gln Asp Glu Glu Glu Thr Pro His Ala Thr Ser Thr Thr Trp Ala Asp 
     290                295                300
Pro Asn Ser Thr Thr Glu Glu Ala Ala Thr Gln Lys Glu Lys Trp Phe 
 305                310                315                320
Glu Asn Glu Trp Gln Gly Lys Asn Pro Pro Thr Pro Ser Glu Asp Ser 
                 325                330                335
His Val Thr Glu Gly Thr Thr Ala Ser Ala His Asn Asn His Pro Ser 
             340                345                350
Gln Arg Met Thr Thr Gln Ser Gln Glu Asp Val Ser Trp Thr Asp Phe 
         355                360                365
Phe Asp Pro Ile Ser His Pro Met Gly Gln Gly His Gln Thr Glu Ser 
     370                375                380
Lys Gly His Ser Ser Gly Asn Gln Asp Ser Gly Val Thr Thr Thr Ser 
 385                390                395                400
Gly Pro Ala Arg Arg Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala 
                 405                410                415
Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn 
             420                425                430
Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly 
         435                440                445
Asn Gly Thr Val Glu Asp Arg Lys Pro Ser Glu Leu Asn Gly Glu Ala 
     450                455                460
Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Pro Thr Glu 
 465                470                475                480
Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Ser 
                 485                490                495
Val Asp Met Lys Ile Gly Val 
             500



<210> 3778
<211> 376
<212> DNA
<213> Homo sapiens
<308> BF748398
<400> 3778

cgttctgta  tcatccttt  tggacatag  gggatgcca  cacggtata  caatagtta  60
ggtaatggt  catcaaagg  attgggcag  tctgtgact  atgtacaat  ttcttcagg  120
ggagctgaa  cattgaagc  atatgtgtc  tactgggag  tgttggatg  gaggatgag  180
atgaagggg  aggccaggg  ggcagctgt  gacatgacg  cccagagca  ggccaggca  240
agcagctgc  gggccgtga  caggtgcat  cggagggtc  ggaccttct  gacgtaagt  300
acatctggg  ggtgtttgg  cggcatgag  agcagatgc  gccgctcat  gaactggat  360
ccgttaagg  aggtga  376



<210> 3779
<211> 1241
<212> PRT
<213> Homo sapiens
<308> P04920
<400> 3779

Met Ser Ser Ala Pro Arg Leu Pro Ala Lys Gly Ala Asp Ser Phe Cys 
  1               5                  10                  15
Thr Pro Glu Pro Glu Ser Leu Gly Pro Gly Thr Pro Gly Phe Pro Glu 
             20                  25                  30
Gln Glu Glu Asp Glu Leu His Arg Thr Leu Gly Val Glu Arg Phe Glu 
         35                  40                  45
Glu Ile Leu Gln Glu Ala Gly Ser Arg Gly Gly Glu Glu Pro Gly Arg 
     50                  55                  60
Ser Tyr Gly Glu Glu Asp Phe Glu Tyr His Arg Gln Ser Ser His His 
 65                  70                  75                  80
Ile His His Pro Leu Ser Thr His Leu Pro Pro Asp Ala Arg Arg Arg 
                 85                  90                  95
Lys Thr Pro Gln Gly Pro Gly Arg Lys Pro Arg Arg Arg Pro Gly Ala 
             100                105                110
Ser Pro Thr Gly Glu Thr Pro Thr Ile Glu Glu Gly Glu Glu Asp Glu 
         115                120                125
Asp Glu Ala Ser Glu Ala Glu Gly Ala Arg Ala Leu Thr Gln Pro Ser 
     130                135                140
Pro Val Ser Thr Pro Ser Ser Val Gln Phe Phe Leu Gln Glu Asp Asp 
 145                150                155                160
Ser Ala Asp Arg Lys Ala Glu Arg Thr Ser Pro Ser Ser Pro Ala Pro 
                 165                170                175
Leu Pro His Gln Glu Ala Thr Pro Arg Ala Ser Lys Gly Ala Gln Ala 
             180                185                190
Gly Thr Gln Val Glu Glu Ala Glu Ala Glu Ala Val Ala Val Ala Ser 
         195                200                205
Gly Thr Ala Gly Gly Asp Asp Gly Gly Ala Ser Gly Arg Pro Leu Pro 
     210                215                220
Lys Ala Gln Pro Gly His Arg Ser Tyr Asn Leu Gln Glu Arg Arg Arg 
 225                230                235                240
Ile Gly Ser Met Thr Gly Ala Glu Gln Ala Leu Leu Pro Arg Val Pro 
                 245                250                255
Thr Asp Glu Ile Glu Ala Gln Thr Leu Ala Thr Ala Asp Leu Asp Leu 
             260                265                270
Met Lys Ser His Arg Phe Glu Asp Val Pro Gly Val Arg Arg His Leu 
         275                280                285
Val Arg Lys Asn Ala Lys Gly Ser Thr Gln Ser Gly Arg Glu Gly Arg 
     290                295                300
Glu Pro Gly Pro Thr Pro Arg Ala Arg Pro Arg Ala Pro His Lys Pro 
 305                310                315                320
His Glu Val Phe Val Glu Leu Asn Glu Leu Leu Leu Asp Lys Asn Gln 
                 325                330                335
Glu Pro Gln Trp Arg Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Asp 
             340                345                350
Val Glu Glu Glu Thr Glu Arg Trp Gly Lys Pro His Val Ala Ser Leu 
         355                360                365
Ser Phe Arg Ser Leu Leu Glu Leu Arg Arg Thr Leu Ala His Gly Ala 
     370                375                380
Val Leu Leu Asp Leu Asp Gln Gln Thr Leu Pro Gly Val Ala His Gln 
 385                390                395                400
Val Val Glu Gln Met Val Ile Ser Asp Gln Ile Lys Ala Glu Asp Arg 
                 405                410                415
Ala Asn Val Leu Arg Ala Leu Leu Leu Lys His Ser His Pro Ser Asp 
             420                425                430
Glu Lys Asp Phe Ser Phe Pro Arg Asn Ile Ser Ala Gly Ser Leu Gly 
         435                440                445
Ser Leu Leu Gly His His His Gly Gln Gly Ala Glu Ser Asp Pro His 
     450                455                460
Val Thr Glu Pro Leu Met Gly Gly Val Pro Glu Thr Arg Leu Glu Val 
 465                470                475                480
Glu Arg Glu Arg Glu Leu Pro Pro Pro Ala Pro Pro Ala Gly Ile Thr 
                 485                490                495
Arg Ser Lys Ser Lys His Glu Leu Lys Leu Leu Glu Lys Ile Pro Glu 
             500                505                510
Asn Ala Glu Ala Thr Val Val Leu Val Gly Cys Val Glu Phe Leu Ser 
         515                520                525
Arg Pro Thr Met Ala Phe Val Arg Leu Arg Glu Ala Val Glu Leu Asp 
     530                535                540
Ala Val Leu Glu Val Pro Val Pro Val Arg Phe Leu Phe Leu Leu Leu 
 545                550                555                560
Gly Pro Ser Ser Ala Asn Met Asp Tyr His Glu Ile Gly Arg Ser Ile 
                 565                570                575
Ser Thr Leu Met Ser Asp Lys Gln Phe His Glu Ala Ala Tyr Leu Ala 
             580                585                590
Asp Glu Arg Glu Asp Leu Leu Thr Ala Ile Asn Ala Phe Leu Asp Cys 
         595                600                605
Ser Val Val Leu Pro Pro Ser Glu Val Gln Gly Glu Glu Leu Leu Arg 
     610                615                620
Ser Val Ala His Phe Gln Arg Gln Met Leu Lys Lys Arg Glu Glu Gln 
 625                630                635                640
Gly Arg Leu Leu Pro Thr Gly Ala Gly Leu Glu Pro Lys Ser Ala Gln 
                 645                650                655
Asp Lys Ala Leu Leu Gln Met Val Glu Ala Ala Gly Ala Ala Glu Asp 
             660                665                670
Asp Pro Leu Arg Arg Thr Gly Arg Pro Phe Gly Gly Leu Ile Arg Asp 
         675                680                685
Val Arg Arg Arg Tyr Pro His Tyr Leu Ser Asp Phe Arg Asp Ala Leu 
     690                695                700
Asp Pro Gln Cys Leu Ala Ala Val Ile Phe Ile Tyr Phe Ala Ala Leu 
 705                710                715                720
Ser Pro Ala Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Gln Asp 
                 725                730                735
Leu Ile Gly Val Ser Glu Leu Ile Met Ser Thr Ala Leu Gln Gly Val 
             740                745                750
Val Phe Cys Leu Leu Gly Ala Gln Pro Leu Leu Val Ile Gly Phe Ser 
         755                760                765
Gly Pro Leu Leu Val Phe Glu Glu Ala Phe Phe Ser Phe Cys Ser Ser 
     770                775                780
Asn His Leu Glu Tyr Leu Val Gly Arg Val Trp Ile Gly Phe Trp Leu 
 785                790                795                800
Val Phe Leu Ala Leu Leu Met Val Ala Leu Glu Gly Ser Phe Leu Val 
                 805                810                815
Arg Phe Val Ser Arg Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser 
             820                825                830
Leu Ile Phe Ile Tyr Glu Thr Phe Tyr Lys Leu Val Lys Ile Phe Gln 
         835                840                845
Glu His Pro Leu His Gly Cys Ser Ala Ser Asn Ser Ser Glu Val Asp 
     850                855                860
Gly Gly Glu Asn Met Thr Trp Ala Gly Ala Arg Pro Thr Leu Gly Pro 
 865                870                875                880
Gly Asn Arg Ser Leu Ala Gly Gln Ser Gly Gln Gly Lys Pro Arg Gly 
                 885                890                895
Gln Pro Asn Thr Ala Leu Leu Ser Leu Val Leu Met Ala Gly Thr Phe 
             900                905                910
Phe Ile Ala Phe Phe Leu Arg Lys Phe Lys Asn Ser Arg Phe Phe Pro 
         915                920                925
Gly Arg Ile Arg Arg Val Ile Gly Asp Phe Gly Val Pro Ile Ala Ile 
     930                935                940
Leu Ile Met Val Leu Val Asp Tyr Ser Ile Glu Asp Thr Tyr Thr Gln 
 945                950                955                960
Lys Leu Ser Val Pro Ser Gly Phe Ser Val Thr Ala Pro Glu Lys Arg 
                 965                970                975
Gly Trp Val Ile Asn Pro Leu Gly Glu Lys Ser Pro Phe Pro Val Trp 
             980                985                990
Met Met Val Ala Ser Leu Leu Pro Ala Ile Leu Val Phe Ile Leu Ile 
         995                1000                1005
Phe Met Glu Thr Gln Ile Thr Thr Leu Ile Ile Ser Lys Lys Glu Arg 
     1010                1015                1020
Met Leu Gln Lys Gly Ser Gly Phe His Leu Asp Leu Leu Leu Ile Val 
 1025                1030                1035                1040
Ala Met Gly Gly Ile Cys Ala Leu Phe Gly Leu Pro Trp Leu Ala Ala 
                 1045                1050                1055
Ala Thr Val Arg Ser Val Thr His Ala Asn Ala Leu Thr Val Met Ser 
             1060                1065                1070
Lys Ala Val Ala Pro Gly Asp Lys Pro Lys Ile Gln Glu Val Lys Glu 
         1075                1080                1085
Gln Arg Val Thr Gly Leu Leu Val Ala Leu Leu Val Gly Leu Ser Ile 
     1090                1095                1100
Val Ile Gly Asp Leu Leu Arg Gln Ile Pro Leu Ala Val Leu Phe Gly 
 1105                1110                1115                1120
Ile Phe Leu Tyr Met Gly Val Thr Ser Leu Asn Gly Ile Gln Phe Tyr 
                 1125                1130                1135
Glu Arg Leu His Leu Leu Leu Met Pro Pro Lys His His Pro Asp Val 
             1140                1145                1150
Thr Tyr Val Lys Lys Val Arg Thr Leu Arg Met His Leu Phe Thr Ala 
         1155                1160                1165
Leu Gln Leu Leu Cys Leu Ala Leu Leu Trp Ala Val Met Ser Thr Ala 
     1170                1175                1180
Ala Ser Leu Ala Phe Pro Phe Ile Leu Ile Leu Thr Val Pro Leu Arg 
 1185                1190                1195                1200
Met Val Val Leu Thr Arg Ile Phe Thr Asp Arg Glu Met Lys Cys Leu 
                 1205                1210                1215
Asp Ala Asn Glu Ala Glu Pro Val Phe Asp Glu Arg Glu Gly Val Asp 
             1220                1225                1230
Glu Tyr Asn Glu Met Pro Met Pro Val 
         1235                1240



<210> 3780
<211> 923
<212> DNA
<213> Rattus norvegicus
<308> M62388
<400> 3780

gggactctt  tctttcaga  tgaccgcgg  gcagctgcg  agcatgtcg  ccccggccc  60
taggaggct  atgcgggat  tcaagcgat  gcaagagga  ccacctgtg  gggtcagtg  120
tgcaccatc  gaaaacaac  tcatgcagt  gaacgcagt  atatttgga  cagaaggga  180
accctttga  gatggtact  ttaaactag  aatagaatt  tctgaagaa  atccaaata  240
accaccaac  gttaggttt  tatccaaaa  gtttcatcc  aatgtgtat  ctgacggca  300
catatgctt  gacatcctg  agaaccgat  gagccccac  tacgacgtc  cctccatct  360
aacttcaat  cagtctctg  tggatgagc  gaatccaaa  agtccggcc  atagccaag  420
agcacagct  tatcaggaa  acaaacggg  gtatgagaa  agggtttcg  ccattgttg  480
gcagagctg  aatgactca  aatagacac  tggtctgtc  acctttcca  cgtcgttgt  540
tataattta  ctcccagta  gaaggctag  aagttttaa  tgccacggg  tttaaggat  600
ctgcagaga  aaaagaaaa  gtccttcag  ttagaacct  caaaagctt  tgtatcttg  660
ttaatgtac  ttttattgc  tggtgtgaa  taagttatt  ctgcataaa  ttgtaatat  720
tcctgtttg  atttttttc  aagtgtata  tgttggtgt  gagttttca  gacagaata  780
acacatttt  taaatctgt  cttttttca  atattgaat  ccttatttt  gaattcttt  840
gatttttaa  ttggagaaa  gcacttaaa  ttttttata  atgaatatt  catgtaaag  900
tgttaaaat  cataacttc  gtg  923



<210> 3781
<211> 152
<212> PRT
<213> Rattus norvegicus
<308> P23567
<400> 3781

Met Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu 
  1               5                  10                  15
Gln Glu Asp Pro Pro Val Gly Val Ser Gly Ala Pro Ser Glu Asn Asn 
             20                  25                  30
Ile Met Gln Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe 
         35                  40                  45
Glu Asp Gly Thr Phe Lys Leu Val Ile Glu Phe Ser Glu Glu Tyr Pro 
     50                  55                  60
Asn Lys Pro Pro Thr Val Arg Phe Leu Ser Lys Met Phe His Pro Asn 
 65                  70                  75                  80
Val Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp 
                 85                  90                  95
Ser Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu 
             100                105                110
Leu Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln 
         115                120                125
Leu Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile 
     130                135                140
Val Glu Gln Ser Trp Asn Asp Ser 
 145                150



<210> 3782
<211> 1355
<212> DNA
<213> Homo sapiens
<308> BC005979
<400> 3782

agactgacc  cggggcagc  gcggagcat  tcgaccccg  cccggagga  gctcatgcg  60
gatttcaag  ggttacaag  ggacccacc  gtgggtgtc  gtggcgcac  atctgaaaa  120
aacatcatg  agtggaatg  agttatatt  ggaccagaa  ggacacctt  tgaagatgg  180
acttttaaa  tagtaatag  attttctga  gaatatcca  ataaaccac  aactgttag  240
tttttatcc  aaatgtttc  tccaaatgt  tatgctgat  gtagcatat  tttagatat  300
cttcagaat  gatggagtc  aacatatga  gtatcttct  tcttaacat  aattcagtc  360
ctgctggat  aaccgaatc  taacagtcc  gccaatagc  aggcagcac  gctttatca  420
gaaaacaaa  gagaatatg  gaaaagagt  tcggccatt  ttgaacaaa  ctggaatga  480
tcataatag  caactggtc  gttaatctt  ttcatcatt  ttgtgtata  tttacctct  540
attagaaag  ctaacaaat  ttaagtgcc  caggtttta  ggattctgc  gaaaaaaaa  600
aaaaattcc  tcagtttag  acctacaaa  gcttgtgta  cttgattaa  gtacttttt  660
ttgcatggt  tgaactaag  tattgctgc  taaatttgt  atatatcct  tttgtattt  720
tttccaagt  tataatgtt  gtgtggagt  ttcatgaca  aatatacac  ttttgtaaa  780
ctgtacttt  ttcaaatat  gaatgcctt  tttttgaat  ctttagatt  ttaaattgg  840
gaaaagcac  taaagtttt  tatatatga  tattacatg  aaagctgtt  aaatacata  900
cttcagtgc  agagacttt  tcacttatt  ccttatgtg  gtaggaggg  ttaataagt  960
tctagctct  catctattg  tagtttcat  tacaatttc  aaagaacat  cttatattt  1020
atcaaggaa  tcttcaaat  tgattctaa  tagcgatta  aatctccaa  tttattttg  1080
atgtacctc  attagtttc  attgagtaa  tctagacat  actggtttg  ctctgtcca  1140
ctctgtatt  aggccattt  ttacagttt  ttcatgcat  acttactgt  aaaactgta  1200
cttttgcga  ttcacagtt  gcacttctg  catgagcag  gaactgatg  gacttgttt  1260
gctgcttgg  agcacttta  aaaattttt  gattaatga  gaaagtaaa  ccataaaca  1320
ttgccgaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  1355



<210> 3783
<211> 152
<212> PRT
<213> Homo sapiens
<308> P23567
<400> 3783

Met Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu 
  1               5                  10                  15
Gln Glu Asp Pro Pro Val Gly Val Ser Gly Ala Pro Ser Glu Asn Asn 
             20                  25                  30
Ile Met Gln Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe 
         35                  40                  45
Glu Asp Gly Thr Phe Lys Leu Val Ile Glu Phe Ser Glu Glu Tyr Pro 
     50                  55                  60
Asn Lys Pro Pro Thr Val Arg Phe Leu Ser Lys Met Phe His Pro Asn 
 65                  70                  75                  80
Val Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp 
                 85                  90                  95
Ser Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu 
             100                105                110
Leu Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln 
         115                120                125
Leu Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile 
     130                135                140
Val Glu Gln Ser Trp Asn Asp Ser 
 145                150



<210> 3784
<211> 923
<212> DNA
<213> Rattus norvegicus
<308> M62388
<400> 3784

gggactctt  tctttcaga  tgaccgcgg  gcagctgcg  agcatgtcg  ccccggccc  60
taggaggct  atgcgggat  tcaagcgat  gcaagagga  ccacctgtg  gggtcagtg  120
tgcaccatc  gaaaacaac  tcatgcagt  gaacgcagt  atatttgga  cagaaggga  180
accctttga  gatggtact  ttaaactag  aatagaatt  tctgaagaa  atccaaata  240
accaccaac  gttaggttt  tatccaaaa  gtttcatcc  aatgtgtat  ctgacggca  300
catatgctt  gacatcctg  agaaccgat  gagccccac  tacgacgtc  cctccatct  360
aacttcaat  cagtctctg  tggatgagc  gaatccaaa  agtccggcc  atagccaag  420
agcacagct  tatcaggaa  acaaacggg  gtatgagaa  agggtttcg  ccattgttg  480
gcagagctg  aatgactca  aatagacac  tggtctgtc  acctttcca  cgtcgttgt  540
tataattta  ctcccagta  gaaggctag  aagttttaa  tgccacggg  tttaaggat  600
ctgcagaga  aaaagaaaa  gtccttcag  ttagaacct  caaaagctt  tgtatcttg  660
ttaatgtac  ttttattgc  tggtgtgaa  taagttatt  ctgcataaa  ttgtaatat  720
tcctgtttg  atttttttc  aagtgtata  tgttggtgt  gagttttca  gacagaata  780
acacatttt  taaatctgt  cttttttca  atattgaat  ccttatttt  gaattcttt  840
gatttttaa  ttggagaaa  gcacttaaa  ttttttata  atgaatatt  catgtaaag  900
tgttaaaat  cataacttc  gtg  923



<210> 3785
<211> 152
<212> PRT
<213> Rattus norvegicus
<308> P23567
<400> 3785

Met Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu 
  1               5                  10                  15
Gln Glu Asp Pro Pro Val Gly Val Ser Gly Ala Pro Ser Glu Asn Asn 
             20                  25                  30
Ile Met Gln Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe 
         35                  40                  45
Glu Asp Gly Thr Phe Lys Leu Val Ile Glu Phe Ser Glu Glu Tyr Pro 
     50                  55                  60
Asn Lys Pro Pro Thr Val Arg Phe Leu Ser Lys Met Phe His Pro Asn 
 65                  70                  75                  80
Val Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp 
                 85                  90                  95
Ser Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu 
             100                105                110
Leu Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln 
         115                120                125
Leu Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile 
     130                135                140
Val Glu Gln Ser Trp Asn Asp Ser 
 145                150



<210> 3786
<211> 1355
<212> DNA
<213> Homo sapiens
<308> BC005979
<400> 3786

agactgacc  cggggcagc  gcggagcat  tcgaccccg  cccggagga  gctcatgcg  60
gatttcaag  ggttacaag  ggacccacc  gtgggtgtc  gtggcgcac  atctgaaaa  120
aacatcatg  agtggaatg  agttatatt  ggaccagaa  ggacacctt  tgaagatgg  180
acttttaaa  tagtaatag  attttctga  gaatatcca  ataaaccac  aactgttag  240
tttttatcc  aaatgtttc  tccaaatgt  tatgctgat  gtagcatat  tttagatat  300
cttcagaat  gatggagtc  aacatatga  gtatcttct  tcttaacat  aattcagtc  360
ctgctggat  aaccgaatc  taacagtcc  gccaatagc  aggcagcac  gctttatca  420
gaaaacaaa  gagaatatg  gaaaagagt  tcggccatt  ttgaacaaa  ctggaatga  480
tcataatag  caactggtc  gttaatctt  ttcatcatt  ttgtgtata  tttacctct  540
attagaaag  ctaacaaat  ttaagtgcc  caggtttta  ggattctgc  gaaaaaaaa  600
aaaaattcc  tcagtttag  acctacaaa  gcttgtgta  cttgattaa  gtacttttt  660
ttgcatggt  tgaactaag  tattgctgc  taaatttgt  atatatcct  tttgtattt  720
tttccaagt  tataatgtt  gtgtggagt  ttcatgaca  aatatacac  ttttgtaaa  780
ctgtacttt  ttcaaatat  gaatgcctt  tttttgaat  ctttagatt  ttaaattgg  840
gaaaagcac  taaagtttt  tatatatga  tattacatg  aaagctgtt  aaatacata  900
cttcagtgc  agagacttt  tcacttatt  ccttatgtg  gtaggaggg  ttaataagt  960
tctagctct  catctattg  tagtttcat  tacaatttc  aaagaacat  cttatattt  1020
atcaaggaa  tcttcaaat  tgattctaa  tagcgatta  aatctccaa  tttattttg  1080
atgtacctc  attagtttc  attgagtaa  tctagacat  actggtttg  ctctgtcca  1140
ctctgtatt  aggccattt  ttacagttt  ttcatgcat  acttactgt  aaaactgta  1200
cttttgcga  ttcacagtt  gcacttctg  catgagcag  gaactgatg  gacttgttt  1260
gctgcttgg  agcacttta  aaaattttt  gattaatga  gaaagtaaa  ccataaaca  1320
ttgccgaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  1355



<210> 3787
<211> 152
<212> PRT
<213> Homo sapiens
<308> P23567
<400> 3787

Met Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu 
  1               5                  10                  15
Gln Glu Asp Pro Pro Val Gly Val Ser Gly Ala Pro Ser Glu Asn Asn 
             20                  25                  30
Ile Met Gln Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe 
         35                  40                  45
Glu Asp Gly Thr Phe Lys Leu Val Ile Glu Phe Ser Glu Glu Tyr Pro 
     50                  55                  60
Asn Lys Pro Pro Thr Val Arg Phe Leu Ser Lys Met Phe His Pro Asn 
 65                  70                  75                  80
Val Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp 
                 85                  90                  95
Ser Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu 
             100                105                110
Leu Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln 
         115                120                125
Leu Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile 
     130                135                140
Val Glu Gln Ser Trp Asn Asp Ser 
 145                150



<210> 3788
<211> 3912
<212> DNA
<213> Rattus norvegicus
<308> M62992
<400> 3788

cacagcttg  gccttagag  agcaactag  gagtgtgac  actgtgcct  tgatatcta  60
atttgaaag  tttgtacaa  aaagattac  aggttcaat  tcagtggct  gggagatag  120
ttagtcaat  aagtgctta  cacacaagc  tggagttcc  agcagccac  tgaaaaagc  180
gaacatagt  gccaacacc  taatcttga  gcaggagag  cggaatagg  gggttcctg  240
ggctttctg  tcagccagc  tgtccagcc  aataggtga  ttacaggtc  cagtaaatg  300
ctccatctc  aaagatgat  tagataata  ctaaaaagg  cacgagggc  acctgctca  360
acacaaggg  ataaacaat  aggaaactc  ccagcattg  ttcttcact  tggaataag  420
cttttggca  tgtagcctc  cccatcact  tgagaggtc  aagtagaag  catactgct  480
tgaagggta  attctgata  attcccatt  aacatggaa  atgtgtcta  ggtactatg  540
gggctatcc  actttgcat  ttggtctca  tgtcccaca  cagtgtggg  ggaattgcc  600
tgggaagat  atgcaatgt  ccctgtcat  atcatcgcc  tataagctt  gtatatgga  660
gtacctgga  gactctgcc  ggagcgggc  taagtcaaa  ctttgagag  ctagtgctt  720
tgcatggga  ggactgtgg  tgctcttgg  ttatggagt  cttggtctc  tttcccctt  780
tccctccca  ccactactg  tttccacct  gagaaaacc  caagtaaca  ctgattagc  840
gacctgggt  tccacttat  cctaagcac  gggctctca  acccaccct  gtgtcctgg  900
tccaactca  tagagtgcc  tcttgtgaa  tgcctcaga  ttccacctt  gtagtggga  960
gtgcgcctg  ccaggagca  tcaactccc  ttggtttac  ggagttggt  atgttagca  1020
aggaaagag  aggggtgct  ccagctctg  atccagccc  ctaccctcc  caccactga  1080
cttgcctgt  ccaaactgc  atctgacca  gtcacttcc  ctgctctag  catcttccc  1140
aggttgcag  cgctgacgg  tttgcccca  agtcgaagt  actgccacc  ggaaattcc  1200
cagccatga  tgggtttaa  tttggaggc  ccggggctc  tgctggcgg  tttacattt  1260
ggaccgcaa  gactgcgac  accacaccc  ccactggct  ttccttctc  gcttctggc  1320
ccggcaccg  agggtttaa  tttgggact  cctcccagc  agctgcgac  accccttcc  1380
ccagcctct  ctcacttgc  acacagacc  caaccacac  gaccccagg  ttcaacttt  1440
gaacaacac  tgcttctgg  ggaacaggc  tctccctgg  gatcagcac  ccaaagctc  1500
gcctaagta  cacagccgc  acaccagcc  cagccaaca  tggcagctt  gggcttggc  1560
gcagtactc  taccaatgc  atctcaggt  ccagcacct  cagccaggg  acagccccc  1620
ctggctttg  ctttggctc  tctaccacc  ctgctccgt  caccggcac  acgggattc  1680
cattcacca  tggcagtgc  tcccagcct  gagcctccg  cttcaacat  ggctctgtg  1740
gtagtttgg  ccagcccac  gcactgtct  gctctccct  cactccagc  actctggcg  1800
caactacgg  aggagcaac  cagccagct  ctgctacac  cactgctgc  accaccagt  1860
cagggtcta  actgtttgc  tcaatagct  ctgctcctg  ctcatccag  actacagtg  1920
tttccctct  agctccagc  acaactgca  ccactccta  tgctgggac  ttgggcttc  1980
gcctcaagg  ccctggagc  gctcctggt  cctccacca  cagcaccac  actactact  2040
ccaccacca  tactactgc  tccacctcc  cctccacca  gaccactgg  tttgcctta  2100
gcctgaaac  cctggtgcc  gctggcccc  gcagcgtgg  agctactgc  ctgcctgcc  2160
ccagcacag  agttgggac  acgacgggt  cagcaatga  ctacgcgca  ctggaaagc  2220
tgatcaaca  gtggagtct  gagctggag  accaggagc  gcacttcct  cagcaggcc  2280
cgcaggtca  tgcctggga  cgcacactg  ttgagaatg  ggagaagat  accagcctg  2340
accgagagg  ggaaaaggt  aagctggat  agaagcgtc  ggaccagga  ctggacttt  2400
tcctgtcac  gcagaagga  ctggaagac  ttctgagcc  gttagagga  tcagtgaag  2460
agcaaagtg  caccatcta  cttcagcat  ctgatgagg  gcgtgagaa  acctacaag  2520
tggctgaga  catcgatgc  cagctcaag  gcatggccc  ggacctcaa  gacattatt  2580
agcacctga  catggctgg  ggccctgca  acaccagtg  cccactgca  cagatctgc  2640
agatcctca  tgcacacat  gactccctt  agtgggtgg  ccagagctc  gccctgctg  2700
agaggaggg  ggaggaggc  agccgtgtg  gtgagagcc  gcgcaagga  caggaacgc  2760
gcctgcgca  tgcctttga  tagccatac  tgagttggg  gtgggggta  ctcttttgt  2820
gtagggctg  tggctttgg  gtggttgta  tgttgagaa  aatgctctt  ggtttggtt  2880
cctgttatc  gaagtggtt  gcgaaggca  gatgtcatg  atgtaataa  ctgtgtgct  2940
tggagacag  tgtgaaggt  actgaactc  aggccagca  ttaaagaac  agggcaaac  3000
catccttta  ccactccaa  acaactgtg  cagtgggat  gcatgctcc  gagattgga  3060
tggagacat  gcttctgtg  ttccctgct  ctctaactc  catctaacc  atgtcctcc  3120
gagcctgtg  tgcacaaag  agagtcacc  agggagact  agcttaaca  cggtttgca  3180
tggctaccc  tctcacccc  ctcttgtga  cttctgtgg  agggactga  tgctgatag  3240
tctttgaga  cagagtggc  gcggatttg  ttctgaatg  cccagtgtc  aaccttaga  3300
tcatagata  tgttgaagg  tggcagtta  gtctggtct  ttttatttc  ccacactct  3360
ctgtagcct  tatggtccc  gatcaaaac  ttgcttttc  aaataaaga  aacattgtg  3420
aatcagact  gctgtgaat  tgtgtgtag  gggtccaag  tttggcagg  cactgctgg  3480
gtgatactc  tcctgtgcc  ccaggttgg  agcgctgga  tgagtgagc  acagagtct  3540
gtctctacc  tctatgggg  gggcaggct  caggtacaa  aagaaagtc  tgtctacca  3600
tgtgcataa  taataagtc  tccattacc  taatagata  aggtgtcat  gtgatgtca  3660
cagcagtag  aaatagggg  acactagaa  ggatttcac  ggaccagca  tagagccac  3720
aagttattt  cttgggtct  gttgggctt  gaagcacaa  agaaagctg  gggtggggt  3780
agggtatag  ggtaagtag  tcggcgggt  agagcactg  ttagctgct  ctctttcaa  3840
gacccaggt  tattcacag  acccacgtg  tagcttaca  ccaccctat  accagtcca  3900
gttatctgg  gt  3912



<210> 3789
<211> 525
<212> PRT
<213> Rattus norvegicus
<308> AAA41789
<400> 3789

Met Ser Gly Phe Asn Phe Gly Gly Thr Gly Ala Pro Ala Gly Gly Phe 
  1               5                  10                  15
Thr Phe Gly Thr Ala Lys Thr Ala Thr Thr Thr Pro Ala Thr Gly Phe 
             20                  25                  30
Ser Phe Ser Ala Ser Gly Thr Gly Thr Gly Gly Phe Asn Phe Gly Thr 
         35                  40                  45
Pro Ser Gln Pro Ala Ala Thr Thr Pro Ser Thr Ser Leu Phe Ser Leu 
     50                  55                  60
Ala Thr Gln Thr Ser Thr Thr Gln Thr Pro Gly Phe Asn Phe Gly Thr 
 65                  70                  75                  80
Thr Pro Ala Ser Gly Gly Thr Gly Phe Ser Leu Gly Ile Ser Thr Pro 
                 85                  90                  95
Lys Leu Ser Leu Ser Ser Thr Ala Ala Thr Pro Ala Thr Ala Asn Thr 
             100                105                110
Gly Ser Phe Gly Leu Gly Ser Ser Thr Leu Thr Asn Ala Ile Ser Gly 
         115                120                125
Ala Ser Thr Ser Ser Gln Gly Thr Ala Pro Thr Gly Phe Val Phe Gly 
     130                135                140
Ser Ser Thr Thr Ser Ala Pro Ser Thr Gly Thr Thr Gly Phe Ser Phe 
 145                150                155                160
Thr Ser Gly Ser Ala Ser Gln Pro Gly Ala Ser Gly Phe Asn Ile Gly 
                 165                170                175
Ser Val Gly Ser Leu Ala Gln Pro Thr Ala Leu Ser Gly Ser Pro Phe 
             180                185                190
Thr Pro Ala Thr Leu Ala Thr Thr Thr Ala Gly Ala Thr Gln Pro Ala 
         195                200                205
Ala Ala Thr Pro Thr Ala Ala Thr Thr Ser Ala Gly Ser Thr Leu Phe 
     210                215                220
Ala Ser Ile Ala Ala Ala Pro Ala Ser Ser Ser Thr Thr Val Leu Ser 
 225                230                235                240
Leu Ser Ala Pro Ala Thr Thr Ala Ala Thr Pro Thr Ala Gly Thr Leu 
                 245                250                255
Gly Phe Ser Leu Lys Ala Pro Gly Ala Ala Pro Gly Ala Ser Thr Thr 
             260                265                270
Ser Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Ala Ser Thr Ser 
         275                280                285
Ser Ser Thr Thr Thr Thr Gly Phe Ala Leu Ser Leu Lys Pro Leu Val 
     290                295                300
Pro Ala Gly Pro Ser Ser Val Ala Ala Thr Ala Leu Pro Ala Ser Ser 
 305                310                315                320
Thr Ala Val Gly Thr Thr Thr Gly Pro Ala Met Thr Tyr Ala Gln Leu 
                 325                330                335
Glu Ser Leu Ile Asn Lys Trp Ser Leu Glu Leu Glu Asp Gln Glu Arg 
             340                345                350
His Phe Leu Gln Gln Ala Thr Gln Val Asn Ala Trp Asp Arg Thr Leu 
         355                360                365
Ile Glu Asn Gly Glu Lys Ile Thr Ser Leu His Arg Glu Val Glu Lys 
     370                375                380
Val Lys Leu Asp Gln Lys Arg Leu Asp Gln Glu Leu Asp Phe Ile Leu 
 385                390                395                400
Ser Gln Gln Lys Glu Leu Glu Asp Leu Leu Ser Pro Leu Glu Glu Ser 
                 405                410                415
Val Lys Glu Gln Ser Gly Thr Ile Tyr Leu Gln His Ala Asp Glu Glu 
             420                425                430
Arg Glu Lys Thr Tyr Lys Leu Ala Glu Asn Ile Asp Ala Gln Leu Lys 
         435                440                445
Arg Met Ala Gln Asp Leu Lys Asp Ile Ile Glu His Leu Asn Met Ala 
     450                455                460
Gly Gly Pro Ala Asp Thr Ser Asp Pro Leu Gln Gln Ile Cys Lys Ile 
 465                470                475                480
Leu Asn Ala His Met Asp Ser Leu Gln Trp Val Asp Gln Ser Ser Ala 
                 485                490                495
Leu Leu Gln Arg Arg Val Glu Glu Ala Ser Arg Val Cys Glu Ser Arg 
             500                505                510
Arg Lys Glu Gln Glu Arg Ser Leu Arg Ile Ala Phe Asp 
         515                520                525



<210> 3790
<211> 3912
<212> DNA
<213> Rattus norvegicus
<308> M62992
<400> 3790

cacagcttg  gccttagag  agcaactag  gagtgtgac  actgtgcct  tgatatcta  60
atttgaaag  tttgtacaa  aaagattac  aggttcaat  tcagtggct  gggagatag  120
ttagtcaat  aagtgctta  cacacaagc  tggagttcc  agcagccac  tgaaaaagc  180
gaacatagt  gccaacacc  taatcttga  gcaggagag  cggaatagg  gggttcctg  240
ggctttctg  tcagccagc  tgtccagcc  aataggtga  ttacaggtc  cagtaaatg  300
ctccatctc  aaagatgat  tagataata  ctaaaaagg  cacgagggc  acctgctca  360
acacaaggg  ataaacaat  aggaaactc  ccagcattg  ttcttcact  tggaataag  420
cttttggca  tgtagcctc  cccatcact  tgagaggtc  aagtagaag  catactgct  480
tgaagggta  attctgata  attcccatt  aacatggaa  atgtgtcta  ggtactatg  540
gggctatcc  actttgcat  ttggtctca  tgtcccaca  cagtgtggg  ggaattgcc  600
tgggaagat  atgcaatgt  ccctgtcat  atcatcgcc  tataagctt  gtatatgga  660
gtacctgga  gactctgcc  ggagcgggc  taagtcaaa  ctttgagag  ctagtgctt  720
tgcatggga  ggactgtgg  tgctcttgg  ttatggagt  cttggtctc  tttcccctt  780
tccctccca  ccactactg  tttccacct  gagaaaacc  caagtaaca  ctgattagc  840
gacctgggt  tccacttat  cctaagcac  gggctctca  acccaccct  gtgtcctgg  900
tccaactca  tagagtgcc  tcttgtgaa  tgcctcaga  ttccacctt  gtagtggga  960
gtgcgcctg  ccaggagca  tcaactccc  ttggtttac  ggagttggt  atgttagca  1020
aggaaagag  aggggtgct  ccagctctg  atccagccc  ctaccctcc  caccactga  1080
cttgcctgt  ccaaactgc  atctgacca  gtcacttcc  ctgctctag  catcttccc  1140
aggttgcag  cgctgacgg  tttgcccca  agtcgaagt  actgccacc  ggaaattcc  1200
cagccatga  tgggtttaa  tttggaggc  ccggggctc  tgctggcgg  tttacattt  1260
ggaccgcaa  gactgcgac  accacaccc  ccactggct  ttccttctc  gcttctggc  1320
ccggcaccg  agggtttaa  tttgggact  cctcccagc  agctgcgac  accccttcc  1380
ccagcctct  ctcacttgc  acacagacc  caaccacac  gaccccagg  ttcaacttt  1440
gaacaacac  tgcttctgg  ggaacaggc  tctccctgg  gatcagcac  ccaaagctc  1500
gcctaagta  cacagccgc  acaccagcc  cagccaaca  tggcagctt  gggcttggc  1560
gcagtactc  taccaatgc  atctcaggt  ccagcacct  cagccaggg  acagccccc  1620
ctggctttg  ctttggctc  tctaccacc  ctgctccgt  caccggcac  acgggattc  1680
cattcacca  tggcagtgc  tcccagcct  gagcctccg  cttcaacat  ggctctgtg  1740
gtagtttgg  ccagcccac  gcactgtct  gctctccct  cactccagc  actctggcg  1800
caactacgg  aggagcaac  cagccagct  ctgctacac  cactgctgc  accaccagt  1860
cagggtcta  actgtttgc  tcaatagct  ctgctcctg  ctcatccag  actacagtg  1920
tttccctct  agctccagc  acaactgca  ccactccta  tgctgggac  ttgggcttc  1980
gcctcaagg  ccctggagc  gctcctggt  cctccacca  cagcaccac  actactact  2040
ccaccacca  tactactgc  tccacctcc  cctccacca  gaccactgg  tttgcctta  2100
gcctgaaac  cctggtgcc  gctggcccc  gcagcgtgg  agctactgc  ctgcctgcc  2160
ccagcacag  agttgggac  acgacgggt  cagcaatga  ctacgcgca  ctggaaagc  2220
tgatcaaca  gtggagtct  gagctggag  accaggagc  gcacttcct  cagcaggcc  2280
cgcaggtca  tgcctggga  cgcacactg  ttgagaatg  ggagaagat  accagcctg  2340
accgagagg  ggaaaaggt  aagctggat  agaagcgtc  ggaccagga  ctggacttt  2400
tcctgtcac  gcagaagga  ctggaagac  ttctgagcc  gttagagga  tcagtgaag  2460
agcaaagtg  caccatcta  cttcagcat  ctgatgagg  gcgtgagaa  acctacaag  2520
tggctgaga  catcgatgc  cagctcaag  gcatggccc  ggacctcaa  gacattatt  2580
agcacctga  catggctgg  ggccctgca  acaccagtg  cccactgca  cagatctgc  2640
agatcctca  tgcacacat  gactccctt  agtgggtgg  ccagagctc  gccctgctg  2700
agaggaggg  ggaggaggc  agccgtgtg  gtgagagcc  gcgcaagga  caggaacgc  2760
gcctgcgca  tgcctttga  tagccatac  tgagttggg  gtgggggta  ctcttttgt  2820
gtagggctg  tggctttgg  gtggttgta  tgttgagaa  aatgctctt  ggtttggtt  2880
cctgttatc  gaagtggtt  gcgaaggca  gatgtcatg  atgtaataa  ctgtgtgct  2940
tggagacag  tgtgaaggt  actgaactc  aggccagca  ttaaagaac  agggcaaac  3000
catccttta  ccactccaa  acaactgtg  cagtgggat  gcatgctcc  gagattgga  3060
tggagacat  gcttctgtg  ttccctgct  ctctaactc  catctaacc  atgtcctcc  3120
gagcctgtg  tgcacaaag  agagtcacc  agggagact  agcttaaca  cggtttgca  3180
tggctaccc  tctcacccc  ctcttgtga  cttctgtgg  agggactga  tgctgatag  3240
tctttgaga  cagagtggc  gcggatttg  ttctgaatg  cccagtgtc  aaccttaga  3300
tcatagata  tgttgaagg  tggcagtta  gtctggtct  ttttatttc  ccacactct  3360
ctgtagcct  tatggtccc  gatcaaaac  ttgcttttc  aaataaaga  aacattgtg  3420
aatcagact  gctgtgaat  tgtgtgtag  gggtccaag  tttggcagg  cactgctgg  3480
gtgatactc  tcctgtgcc  ccaggttgg  agcgctgga  tgagtgagc  acagagtct  3540
gtctctacc  tctatgggg  gggcaggct  caggtacaa  aagaaagtc  tgtctacca  3600
tgtgcataa  taataagtc  tccattacc  taatagata  aggtgtcat  gtgatgtca  3660
cagcagtag  aaatagggg  acactagaa  ggatttcac  ggaccagca  tagagccac  3720
aagttattt  cttgggtct  gttgggctt  gaagcacaa  agaaagctg  gggtggggt  3780
agggtatag  ggtaagtag  tcggcgggt  agagcactg  ttagctgct  ctctttcaa  3840
gacccaggt  tattcacag  acccacgtg  tagcttaca  ccaccctat  accagtcca  3900
gttatctgg  gt  3912



<210> 3791
<211> 525
<212> PRT
<213> Rattus norvegicus
<308> AAA41789
<400> 3791

Met Ser Gly Phe Asn Phe Gly Gly Thr Gly Ala Pro Ala Gly Gly Phe 
  1               5                  10                  15
Thr Phe Gly Thr Ala Lys Thr Ala Thr Thr Thr Pro Ala Thr Gly Phe 
             20                  25                  30
Ser Phe Ser Ala Ser Gly Thr Gly Thr Gly Gly Phe Asn Phe Gly Thr 
         35                  40                  45
Pro Ser Gln Pro Ala Ala Thr Thr Pro Ser Thr Ser Leu Phe Ser Leu 
     50                  55                  60
Ala Thr Gln Thr Ser Thr Thr Gln Thr Pro Gly Phe Asn Phe Gly Thr 
 65                  70                  75                  80
Thr Pro Ala Ser Gly Gly Thr Gly Phe Ser Leu Gly Ile Ser Thr Pro 
                 85                  90                  95
Lys Leu Ser Leu Ser Ser Thr Ala Ala Thr Pro Ala Thr Ala Asn Thr 
             100                105                110
Gly Ser Phe Gly Leu Gly Ser Ser Thr Leu Thr Asn Ala Ile Ser Gly 
         115                120                125
Ala Ser Thr Ser Ser Gln Gly Thr Ala Pro Thr Gly Phe Val Phe Gly 
     130                135                140
Ser Ser Thr Thr Ser Ala Pro Ser Thr Gly Thr Thr Gly Phe Ser Phe 
 145                150                155                160
Thr Ser Gly Ser Ala Ser Gln Pro Gly Ala Ser Gly Phe Asn Ile Gly 
                 165                170                175
Ser Val Gly Ser Leu Ala Gln Pro Thr Ala Leu Ser Gly Ser Pro Phe 
             180                185                190
Thr Pro Ala Thr Leu Ala Thr Thr Thr Ala Gly Ala Thr Gln Pro Ala 
         195                200                205
Ala Ala Thr Pro Thr Ala Ala Thr Thr Ser Ala Gly Ser Thr Leu Phe 
     210                215                220
Ala Ser Ile Ala Ala Ala Pro Ala Ser Ser Ser Thr Thr Val Leu Ser 
 225                230                235                240
Leu Ser Ala Pro Ala Thr Thr Ala Ala Thr Pro Thr Ala Gly Thr Leu 
                 245                250                255
Gly Phe Ser Leu Lys Ala Pro Gly Ala Ala Pro Gly Ala Ser Thr Thr 
             260                265                270
Ser Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Ala Ser Thr Ser 
         275                280                285
Ser Ser Thr Thr Thr Thr Gly Phe Ala Leu Ser Leu Lys Pro Leu Val 
     290                295                300
Pro Ala Gly Pro Ser Ser Val Ala Ala Thr Ala Leu Pro Ala Ser Ser 
 305                310                315                320
Thr Ala Val Gly Thr Thr Thr Gly Pro Ala Met Thr Tyr Ala Gln Leu 
                 325                330                335
Glu Ser Leu Ile Asn Lys Trp Ser Leu Glu Leu Glu Asp Gln Glu Arg 
             340                345                350
His Phe Leu Gln Gln Ala Thr Gln Val Asn Ala Trp Asp Arg Thr Leu 
         355                360                365
Ile Glu Asn Gly Glu Lys Ile Thr Ser Leu His Arg Glu Val Glu Lys 
     370                375                380
Val Lys Leu Asp Gln Lys Arg Leu Asp Gln Glu Leu Asp Phe Ile Leu 
 385                390                395                400
Ser Gln Gln Lys Glu Leu Glu Asp Leu Leu Ser Pro Leu Glu Glu Ser 
                 405                410                415
Val Lys Glu Gln Ser Gly Thr Ile Tyr Leu Gln His Ala Asp Glu Glu 
             420                425                430
Arg Glu Lys Thr Tyr Lys Leu Ala Glu Asn Ile Asp Ala Gln Leu Lys 
         435                440                445
Arg Met Ala Gln Asp Leu Lys Asp Ile Ile Glu His Leu Asn Met Ala 
     450                455                460
Gly Gly Pro Ala Asp Thr Ser Asp Pro Leu Gln Gln Ile Cys Lys Ile 
 465                470                475                480
Leu Asn Ala His Met Asp Ser Leu Gln Trp Val Asp Gln Ser Ser Ala 
                 485                490                495
Leu Leu Gln Arg Arg Val Glu Glu Ala Ser Arg Val Cys Glu Ser Arg 
             500                505                510
Arg Lys Glu Gln Glu Arg Ser Leu Arg Ile Ala Phe Asp 
         515                520                525



<210> 3792
<211> 2130
<212> DNA
<213> Rattus norvegicus
<308> M63122
<400> 3792

ttttctccg  gttttctga  ctctggctc  tgatcgggc  tactggata  gagaatcct  60
gaggaccgt  ccctgattt  catctacct  tgactttga  cctttctaa  ccggggctc  120
cgctgccaa  acccgggcc  cctggtccg  tcgtcttac  tcattcacc  gcgttgcca  180
ttgctgccc  gtccccagc  ccaatgggg  agtgagaga  gccactgcc  gccggacat  240
ggtctcccc  tcgtgcctg  cctgctgct  tcactggtg  tcctggctc  gctgatggg  300
atacaccca  caggggtca  cggactggt  ccttctctt  gtgaccggg  gaagaggga  360
aatttgtgt  cccagggaa  gtatgccca  ccaaagaat  attccatct  ctgcaccaa  420
tgccacaaa  gaacctact  ggtgagtga  tgtccaagc  cagggcagg  aacagtctg  480
gaggtgtgt  ataaaggca  ctttacagc  tcgcagaac  acgtcagac  gtgtctcag  540
tgcaagaca  gtcggaaag  aatgttcca  gtggagatt  ctccttgca  agctgacat  600
gacaccgtg  gtggctgca  gaagaacca  ttccagcgc  acctgagtg  gacgcattt  660
cagtgtgtg  actgcagcc  ctgcttcaa  ggcaccgtg  caatcccct  taaggagaa  720
cagaacacc  tgtgtaact  ccacgcagg  ttctttcta  gcggaaatg  gtgcacccc  780
tgcagccac  gcaagaaaa  tcaggaatg  atgaagctg  gcctacctc  agttgcaaa  840
gtcacaaac  cccaggact  aggtactgc  gtgctgttg  ctctggtta  cttcctagg  900
ctttgcctt  tattcttta  ctgcatcag  ctactgtgc  gatatcccc  gtggaggcc  960
agggtctac  ccatcattt  tagggattc  gctcctgtc  aagaggtgg  gggtgaagg  1020
attgttact  agcccctaa  tccagcctc  atcccagcc  tcagcccca  ccccggctt  1080
aaccccact  tgggcttca  caccacccc  cgcttcagt  atcctgtct  cagtacccc  1140
atcagcccc  tcttcggtc  tagtaactg  cacaacttc  tgccacctg  aagagaggt  1200
gtcccaacc  agggtgctg  ccctctcct  tacggatcc  tcaaccctg  gccaatccc  1260
gcccctgtt  ggaaatggg  agacgtcgt  gcggcccag  cacaacggc  tgacactgc  1320
gaccctgcg  tgctgtatg  tgtggtgga  ggcgtgcct  cgacacgct  gaaggagtt  1380
atgcggctc  tggggctga  cgagcacga  atcgagcgg  tggagctgc  gaacgggcg  1440
tgcctccgc  aggctcatt  cagcatgct  gaagcctgg  ggcgccgca  accgcgaca  1500
gaggccacg  tggacgtag  gggccgcgt  ctttgcgac  tgaacctgc  tggctgcct  1560
gagaacatc  gcgagactc  agaaagccc  gcccactcg  ccacgaccc  cctcccgcg  1620
taaggccac  cccccacct  aggaacggg  ctcgaagga  catcctgct  gatgccctg  1680
ttccctgtg  acctcctct  tggtcctct  gggggcagg  tcgatctgg  aggctcgat  1740
tggcagcca  ttccttggt  ctaccgact  ggtgtacat  gcttttccc  gctgccgag  1800
acagcctgt  ccagccact  gtgcatggc  gggaagtgt  ccatctgct  ccagacagc  1860
gagggtgcc  aaagccagg  gaggtgatt  tggagaaaa  gcacaatct  tctgatacc  1920
acttgggat  caaggaccc  aacaaagct  ctcagggcc  cctcagttg  tttctgggc  1980
cttttcaca  tagataaaa  agtctttgt  ttgattata  cacactaat  gatgaacgg  2040
tgaactccc  aaggtaggg  caagcacag  acagtgggg  ctccagctg  agcccccga  2100
tcttgtaaa  acactaaaa  tctaaaagtg  2130



<210> 3793
<211> 461
<212> PRT
<213> Rattus norvegicus
<308> P22934
<400> 3793

Met Gly Leu Pro Ile Val Pro Gly Leu Leu Leu Ser Leu Val Leu Leu 
  1               5                  10                  15
Ala Leu Leu Met Gly Ile His Pro Ser Gly Val Thr Gly Leu Val Pro 
             20                  25                  30
Ser Leu Gly Asp Arg Glu Lys Arg Asp Asn Leu Cys Pro Gln Gly Lys 
         35                  40                  45
Tyr Ala His Pro Lys Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
     50                  55                  60
Gly Thr Tyr Leu Val Ser Asp Cys Pro Ser Pro Gly Gln Glu Thr Val 
 65                  70                  75                  80
Cys Glu Val Cys Asp Lys Gly Thr Phe Thr Ala Ser Gln Asn His Val 
                 85                  90                  95
Arg Gln Cys Leu Ser Cys Lys Thr Cys Arg Lys Glu Met Phe Gln Val 
             100                105                110
Glu Ile Ser Pro Cys Lys Ala Asp Met Asp Thr Val Cys Gly Cys Lys 
         115                120                125
Lys Asn Gln Phe Gln Arg Tyr Leu Ser Glu Thr His Phe Gln Cys Val 
     130                135                140
Asp Cys Ser Pro Cys Phe Asn Gly Thr Val Thr Ile Pro Cys Lys Glu 
 145                150                155                160
Lys Gln Asn Thr Val Cys Asn Cys His Ala Gly Phe Phe Leu Ser Gly 
                 165                170                175
Asn Glu Cys Thr Pro Cys Ser His Cys Lys Lys Asn Gln Glu Cys Met 
             180                185                190
Lys Leu Cys Leu Pro Pro Val Ala Asn Val Thr Asn Pro Gln Asp Ser 
         195                200                205
Gly Thr Ala Val Leu Leu Pro Leu Val Ile Phe Leu Gly Leu Cys Leu 
     210                215                220
Leu Phe Phe Ile Cys Ile Ser Leu Leu Cys Arg Tyr Pro Gln Trp Arg 
 225                230                235                240
Pro Arg Val Tyr Ser Ile Ile Cys Arg Asp Ser Ala Pro Val Lys Glu 
                 245                250                255
Val Glu Gly Glu Gly Ile Val Thr Lys Pro Leu Thr Pro Ala Ser Ile 
             260                265                270
Pro Ala Phe Ser Pro Asn Pro Gly Phe Asn Pro Thr Leu Gly Phe Ser 
         275                280                285
Thr Thr Pro Arg Phe Ser His Pro Val Ser Ser Thr Pro Ile Ser Pro 
     290                295                300
Val Phe Gly Pro Ser Asn Trp His Asn Phe Val Pro Pro Val Arg Glu 
 305                310                315                320
Val Val Pro Thr Gln Gly Ala Asp Pro Leu Leu Tyr Gly Ser Leu Asn 
                 325                330                335
Pro Val Pro Ile Pro Ala Pro Val Arg Lys Trp Glu Asp Val Val Ala 
             340                345                350
Ala Gln Pro Gln Arg Leu Asp Thr Ala Asp Pro Ala Met Leu Tyr Ala 
         355                360                365
Val Val Asp Gly Val Pro Pro Thr Arg Trp Lys Glu Phe Met Arg Leu 
     370                375                380
Leu Gly Leu Ser Glu His Glu Ile Glu Arg Leu Glu Leu Gln Asn Gly 
 385                390                395                400
Arg Cys Leu Arg Glu Ala His Tyr Ser Met Leu Glu Ala Trp Arg Arg 
                 405                410                415
Arg Thr Pro Arg His Glu Ala Thr Leu Asp Val Val Gly Arg Val Leu 
             420                425                430
Cys Asp Met Asn Leu Arg Gly Cys Leu Glu Asn Ile Arg Glu Thr Leu 
         435                440                445
Glu Ser Pro Ala His Ser Ser Thr Thr His Leu Pro Arg 
     450                455                460



<210> 3794
<211> 2087
<212> DNA
<213> Homo sapiens
<308> M33294
<400> 3794

ctttggggt  caagatcac  gggaccagg  cgtgatctc  atgcccgag  ctcaaccct  60
aactgtcac  ccaaagcac  tgggacgtc  tggacagac  gagtcccgg  aagccccag  120
actgccgct  ccacactgc  ctgagccca  atgggggag  gagaggcca  agctgtctg  180
catgggcct  tccaccgtg  ctgacctgc  gctgccgct  gtgctcctg  agctgttgg  240
gggaatata  ccctcaggg  ttattggac  ggtccctca  ctaggggac  gggagaaga  300
agatagtgt  tgtccccaa  gaaaatata  ccaccctca  aataattcg  tttgctgta  360
caagtgcca  aaaggaacc  acttgtaca  tgactgtcc  ggcccgggg  aggatacgg  420
ctgcaggga  tgtgagagc  gctccttca  cgcttcaga  aaccacctc  gacactgcc  480
cagctgctc  aaatgccga  aggaaatgg  tcaggtgga  atctcttct  gcacagtgg  540
ccgggacac  gtgtgtggc  gcaggaaga  ccagtaccg  cattattgg  gtgaaaacc  600
tttccagtg  ttcaattgc  gcctctgcc  caatgggac  gtgcacctc  cctgccagg  660
gaaacagaa  accgtgtgc  cctgccatg  aggtttctt  ctaagagaa  acgagtgtg  720
ctcctgtag  aactgtaag  aaagcctgg  gtgcacgaa  ttgtgccta  cccagattg  780
gaatgttaa  ggcactgag  actcaggca  cacagtgct  ttgcccctg  tcattttct  840
tggtctttg  cttttatcc  tcctcttca  tggtttaat  tatcgctac  aacggtgga  900
gtccaagct  tactccatt  tttgtggga  atcgacacc  gaaaaagag  gggagcttg  960
aggaactac  actaagccc  tggccccaa  cccaagctt  agtcccact  caggcttca  1020
ccccaccct  ggcttcagt  ccgtgccca  ttccacctt  acctccagc  ccacctata  1080
ccccggtga  tgtcccaac  ttgcggctc  ccgcagaga  gtggcacca  cctatcagg  1140
ggctgaccc  atccttgcg  cagccctcg  ctccgaccc  atccccaac  cccttcaga  1200
gtgggagga  agcgcccac  agccacaga  cctagacac  gatgacccc  cgacgctgt  1260
cgccgtggt  gagaacgtg  ccccgttgc  ctggaagga  ttcgtgcgg  gcctagggc  1320
gagcgacca  gagatcgat  ggctggagc  gcagaacgg  cgctgcctg  gcgaggcgc  1380
atacagcat  ctggcgacc  ggaggcggc  cacgccgcg  cgcgaggcc  cgctggagc  1440
gctgggacg  gtgctccgc  acatggacc  gctgggctg  ctggaggac  tcgaggagg  1500
gctttgcgg  cccgccgcc  tcccgcccg  gcccagtct  ctcagatga  gctgcgccc  1560
gcgggcagc  ctaaggacc  tcctgcgag  tcgccttcc  accccactt  tttctggaa  1620
ggaggggtc  tgcaggggc  agcaggagc  agcagccgc  tacttggtg  taacccctc  1680
atgtacata  cttttctca  ctgcctgcg  gccgccgac  gtcagcgct  tgcgcgcgg  1740
gagaggtgc  ccgtgggct  aagagcctg  gtgggtggt  tgcgaggat  agggacgct  1800
tgcctcatg  ccgttttgg  tgtcctcac  agcaaggct  ctcgggggc  cctggttcg  1860
ccctgagcc  ttttcacag  gcataagca  ttttttttg  ttttgtttt  ttttgtttt  1920
tttttaaat  aatcatgtt  cactaatag  aacttggca  tcctgtgcc  tctgcctgg  1980
caagcacat  gcaagctga  ctgtcctaa  gcaggggcg  gcacggaac  atggggcct  2040
cagctggag  tgtggactt  tgtacatac  ctaaaattc  gaagtta  2087



<210> 3795
<211> 455
<212> PRT
<213> Homo sapiens
<308> P19438
<400> 3795

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
  1               5                  10                  15
Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
             20                  25                  30
His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
         35                  40                  45
Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
     50                  55                  60
Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
 65                  70                  75                  80
Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                 85                  90                  95
Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
             100                105                110
Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
         115                120                125
Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
     130                135                140
Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
 145                150                155                160
Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                 165                170                175
Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
             180                185                190
Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
         195                200                205
Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu 
     210                215                220
Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys 
 225                230                235                240
Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu 
                 245                250                255
Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser 
             260                265                270
Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val 
         275                280                285
Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys 
     290                295                300
Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly 
 305                310                315                320
Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn 
                 325                330                335
Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp 
             340                345                350
Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro 
         355                360                365
Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu 
     370                375                380
Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
 385                390                395                400
Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala 
                 405                410                415
Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly 
             420                425                430
Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro 
         435                440                445
Pro Ala Pro Ser Leu Leu Arg 
     450                455



<210> 3796
<211> 3761
<212> DNA
<213> Rattus norvegicus
<308> M63485
<400> 3796

tdatdnact  agagaggta  ctctccttt  ccctctccc  tccctaaga  ttgtctgct  60
gttctcagc  tgaagaaga  tctacagtc  ttattgatc  tttttcttg  cgttaccat  120
tttgaagca  agttgacct  gctttctag  ttgagcttt  tttttggcc  tcttttaaa  180
cattttttt  tttgatcta  aaaatagac  agagatagt  ctacaatgt  caagtcatt  240
cagcagtca  ctctcggta  ggattcaca  ggtcatggg  gtgacctgt  tgcagcagg  300
ataggcctt  ttgctgctg  tacccagtc  ttaagtatg  cagcatctc  tggaaggat  360
aaccagggt  ctgcacgcc  tgctagctt  atgaatctt  gaatgagtt  ttcattgaa  420
caacaagga  ctcatagtg  actgtcttc  gctagtact  cttcccata  tttgcagtc  480
atatttaac  ttggaagta  aggtccact  cctttgtct  ctcaacacc  tggagatac  540
gaccaggcc  gtaatattt  ggccagctt  ggtctgtct  ctagagact  agatgaact  600
agtcgttat  cagaggaca  gattactcc  gagaacttg  cccaaattc  tctacagct  660
aaaaggagg  gaactgaag  aggccctac  ttgagttat  gtagagatg  cagatctgc  720
acacgggag  caccataca  agtacctag  gatgattgg  aagaaaaaa  gcattttag  780
agagatagt  ttgatgatc  tggtcctag  ctcaaccca  tgcttgatt  tgaccatgg  840
agtcgttct  aagaatctg  ttattatga  agaatggat  atgaagatg  cagattaag  900
gatggagaa  ggtgtaggg  tgattcttt  tttggtgag  cctcgcata  ctatcataa  960
tttgacagt  agtatgaga  aatgggacg  ggtcctggc  ccttacaag  gagatctct  1020
tttgagaaa  agaggggcg  tcctccaag  agcaatatt  aagacttcc  tggactctt  1080
ccgaagggt  atccccatc  gtgctctat  tgtgatttg  cagttcatt  taataagga  1140
tggagtcaa  atatcaatg  agcaagtca  agtcgtcga  gccagcttc  tcttgaaat  1200
tacccagaa  ggaatcctg  caatgatac  ggacacaca  tgggtgatc  attcatgct  1260
cagcagtca  caaacccag  accgggaat  ctgggaccg  cacctcctt  atttcatct  1320
ggaggacca  cagttggac  aagaggaaa  ctgggtgct  gtaatggaa  cctacaggg  1380
ccaagacac  tgcaaaaag  cagagtgga  accagccga  ttgttcaca  tatggattt  1440
cagcgagga  aaaacttga  ataccagct  ttacaactg  tagaaccat  tggagtcat  1500
tcaaatcat  tgattctaa  taaaattaa  gaggcattt  ttgaaatgg  gaccacaga  1560
gatgctcag  ctgctgtgg  ttattatac  actacacca  cattagtgt  tggcaagcc  1620
gtgagagtt  atttatccc  gaagtataa  agaataaag  aacctgaag  aaaaccaga  1680
gagaagttt  atcaaaagc  agaacttgg  cgtgtgata  atctcagca  tttacctca  1740
tctggctat  ctgacagtg  tgtcctcaa  cttgcagag  cttatggga  aataaaaaa  1800
tatatattg  tgaggatga  aagtcaggc  tttattgag  tggaaacca  agaagatgc  1860
atggcaatg  ttgaccact  tctaaagaa  gcactttgg  ttcagggaa  atgtgttaa  1920
gttgacttg  ctgagaaat  taaaaaact  gtgctgagg  ttcctaaca  aggcattga  1980
ttactgaaa  aagataaat  tcggaaaag  tcctattct  cagatggaa  agaatctcc  2040
agtgataag  agtccaaaa  tgatggtgc  cagaagact  agaatccag  tgagggtaa  2100
gaacaagaa  agaagtcgg  tgaggatgg  gagaaagac  ccaaggatg  ccagacaga  2160
caggagccc  gtatgcttc  tgaatctga  gatgaattg  ttgtcgatg  ggaagaagc  2220
gcagcacta  tagaaagtg  aagctcagt  ggtgatgag  ctgatcttg  taatttagg  2280
gatgtatct  ctgatggga  aaaggagcc  tcagataaa  ctgtgaaaa  agatgcaag  2340
gcaacatcc  agaaaaaac  taaaaaggt  gacaagatt  aggaacttg  tcaagaaaa  2400
gaagctgca  tggaaaatg  gattaaaaa  gaggaaaat  cagaaccag  tgctgaatc  2460
gctgagaat  ctgatgatc  aaacaaaga  gcaagtgat  attcagatg  ccaaaatga  2520
gagaacaag  aggactata  aattccaga  gagtataga  ttggaccat  tcagcctaa  2580
gttcctggt  gtatagact  tgtgatacc  aaaacaggg  tttactgta  gctgtgttc  2640
ctcttttat  caaatgaag  agttgcaaa  aatactcat  gcagcagcc  tcctcatta  2700
cagaaatta  agaaatttc  gaataaatt  gcagaagaa  gcaggcaga  gaaggaaag  2760
taagatgta  aagaagctt  tatttcaaa  aaaacaatg  ttctttgat  ttaatgtta  2820
cctttttta  atacaatac  gatagttag  aaactactg  gactctttt  ttttagtgg  2880
aaataatag  tgtctgttc  tgtgtttaa  tgttatagc  aaaagtaca  atacggtta  2940
gttaatgaa  aagtttttg  ttcatcagt  acaacagac  aaagtactt  ctagagatt  3000
gctgttgta  gtaagctat  gaaaaacaa  ttgcaccac  aagagaaag  taacataga  3060
ccattcaga  aactgaaat  tagtagttt  aggcttcaa  gaaatgtca  cattttgat  3120
ccattcaat  aagtacaaa  ccaatgtat  ttttattac  tttcatctg  aacagtcca  3180
attttaatc  gagccttgc  gacttttca  ttgtgacgt  tgtaagctg  ttcggttgc  3240
ttgcatttt  agagaactt  attaacgtg  gaattcaat  gcaggtgca  ttttctttt  3300
atgttcatg  tgtttagat  ataagatat  ttaagtaat  ggctttaga  ttgtaattt  3360
tttcctctg  gttcctgct  ggttttgta  tgtagtagt  aatgttatt  cagtgaaat  3420
taaaaatat  accgttctc  ttgaccagt  ttaatttct  gagaaccta  tccttgtca  3480
ttgaatcct  tagctgtca  acatctccg  tataagcaa  atttgattt  tgaagtgtg  3540
aaaccatct  tattttcaa  atgtaattt  acatttctg  attttaaaa  tttggccat  3600
attctagaa  cacgttcta  ttatgtacc  acacatgtg  cctatgtga  cagaaattt  3660
catgtataa  ctgtgttta  ttgtaactc  ctggttata  actgcttat  tctgtggat  3720
caagttact  aagtgaata  caataaaaa  aaaaacaag  t  3761



<210> 3797
<211> 845
<212> PRT
<213> Rattus norvegicus
<308> P43244
<400> 3797

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Gly Arg Asp Ser Gln Gly 
  1               5                  10                  15
His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
             20                  25                  30
Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
         35                  40                  45
Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
     50                  55                  60
Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
 65                  70                  75                  80
His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                 85                  90                  95
Leu Ser Ser Gln His Arg Gly Asp Thr Asp Gln Ala Ser Asn Ile Leu 
             100                105                110
Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp Glu Leu Ser Arg Tyr 
         115                120                125
Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln Ile Leu Leu Gln 
     130                135                140
Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr Leu Ser Tyr Gly Arg 
 145                150                155                160
Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr Arg Val Pro Arg Asp 
                 165                170                175
Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser Phe Asp Asp Arg 
             180                185                190
Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp His Gly Ser Arg Ser 
         195                200                205
Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu Asp Asp Arg Leu 
     210                215                220
Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser 
 225                230                235                240
His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg Met Gly Arg Gly 
                 245                250                255
Pro Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys Lys Arg Gly Ala 
             260                265                270
Pro Pro Ser Ser Asn Ile Glu Asp Phe His Gly Leu Leu Pro Lys Gly 
         275                280                285
Tyr Pro His Leu Cys Ser Ile Cys Asp Leu Pro Val His Ser Asn Lys 
     290                295                300
Glu Trp Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln 
 305                310                315                320
Leu Leu Leu Glu Ile Tyr Pro Glu Trp Asn Pro Asp Asn Asp Thr Gly 
                 325                330                335
His Thr Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala 
             340                345                350
Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro 
         355                360                365
Ala Val Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln 
     370                375                380
Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val 
 385                390                395                400
His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu 
                 405                410                415
Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn 
             420                425                430
Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln 
         435                440                445
Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys 
     450                455                460
Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro 
 465                470                475                480
Glu Gly Lys Pro Asp Glu Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg 
                 485                490                495
Val Ile His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala 
             500                505                510
Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu 
         515                520                525
Met Arg Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp 
     530                535                540
Ala Met Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln 
 545                550                555                560
Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val 
                 565                570                575
Leu Arg Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser 
             580                585                590
Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser Asp Lys 
         595                600                605
Lys Ser Lys Thr Asp Gly Ala Gln Lys Thr Glu Asn Pro Ala Glu Gly 
     610                615                620
Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp Thr Lys 
 625                630                635                640
Asp Asp Gln Thr Glu Gln Glu Pro Ser Met Leu Leu Glu Ser Glu Asp 
                 645                650                655
Glu Leu Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Ile Glu Ser Gly 
             660                665                670
Ser Ser Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ser 
         675                680                685
Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Ala 
     690                695                700
Ser Ala Thr Ser Lys Lys Lys Leu Lys Lys Val Asp Lys Ile Glu Glu 
 705                710                715                720
Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys Asn Glu 
                 725                730                735
Glu Asn Thr Glu Pro Gly Ala Glu Ser Ala Glu Asn Ala Asp Asp Pro 
             740                745                750
Asn Lys Asp Ala Ser Asp Asn Ser Asp Gly Gln Asn Asp Glu Asn Lys 
         755                760                765
Glu Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr Gln Pro 
     770                775                780
Asn Val Pro Gly Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly Phe Tyr 
 785                790                795                800
Cys Lys Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu Val Ala Lys Asn 
                 805                810                815
Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys Phe Leu 
             820                825                830
Asn Lys Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu Ser 
         835                840                845



<210> 3798
<211> 3828
<212> DNA
<213> Homo sapiens
<308> BC015031
<400> 3798

ggtacctct  cttttccct  tccctttcc  taagagttg  ctgctggtt  tcagcttga  60
gaagattct  cagtcctta  tgatccttt  tcttggcgt  accattttt  gaagcaaag  120
taacctagc  ttctagttt  agctttctt  ttggccgtc  ttaaaaaaa  ttttttttt  180
aatctataa  atagacaag  gctagttct  caatgtcca  gtcattcca  cagtcatct  240
tcagtaggg  ctcacaggg  catgggcgt  acctgtctg  ggcaggaat  ggccttctt  300
ctgctgcta  ccagtcttt  agtatgcca  catctcttg  aaggatgaa  cagggtact  360
cacgccttg  tagtttaat  aatcttgga  tgagttctt  attgaatca  caaggagct  420
atagtgcac  gtcttctgc  agtacttct  cccataatt  gcagtctat  tttaacatt  480
gaagtagag  tccactccc  ttatcttct  aacaccgtg  agatgcaga  caggccagt  540
acattttgg  cagctttgg  ctgtctgct  gagacttag  tgaactgag  cgttatcca  600
aggacaaga  tactcctga  aatttgccc  aaatccttc  acagcttaa  aggaggaga  660
ctgaagaag  ccctacctt  agttatggt  gagatggca  atctgctac  cgggagcca  720
catacagag  acctaggga  gattgggaa  aaaaaaggc  ctttagaag  gatagtttt  780
atgatcgtg  tcctagtct  aacccagtg  ttgattatg  ccatggaag  cgttctcaa  840
aatctggtt  ttatgacag  atggattat  aagatgaca  attaagaga  ggagaaagg  900
gtagggatg  ttctttttt  ggtgagacc  cgcataact  tcataaatt  gacagtgag  960
atgagagaa  gggacgtgg  cctggcccc  tacaagaga  atctctctt  gagaaaaag  1020
gaggcgctc  tccaagtag  aatattgaa  acttccatg  actcttacc  aagggttat  1080
cccatctgt  ctctatatg  gatttgcca  ttcattcta  taaggagtg  agtcaacat  1140
tcaatggag  aagtcacag  cgtcgatgc  agcttcttc  tgaaatcta  ccagaatgg  1200
atcctgaca  tgatacagg  cacacaatg  gtgatccat  catgttgca  cagtctaca  1260
atccagcac  aggaattct  ggacctcca  ctccctcat  tcatcttgg  ggaccagca  1320
ttggaccaa  aggaaatct  ggtgctgga  atggaaacc  gcaaggacc  agacacatg  1380
agaaaggca  agtggaaac  agcagagtt  ttcacatca  ggattttca  cgagggaaa  1440
acttgagat  ccagctatt  cagctggta  aaccatttg  agtcatttc  aatcatctg  1500
ttctaaata  aattaatga  gcatttatt  aaatggcaa  cacagagga  gctcaggcc  1560
cagtggatt  ttacacaac  acaccagcg  tagtatttg  caagccagt  agagttcat  1620
tatcccaga  gtataaaag  ataaagaaa  ctgaaggaa  gccagatca  aagtttgat  1680
aaaagcaag  gcttggacg  gtgatacat  tcagcaatt  gccgcattc  ggctattct  1740
atagtgctg  tctcaagct  gctgagcct  atgggaaaa  aaagaatta  atattgatg  1800
ggatgaaaa  tcaggcttt  attgagatg  agacaagag  agatgcaat  gcaatggtt  1860
accattgtt  gaaaaaagc  ctttggttt  aggggagat  tgtgaaggt  gacctgtct  1920
agaaatata  aaaactggt  ctgaggatt  caaacagag  cattgattt  ctgaaaaaa  1980
ataaatccc  aaaaagatc  tactctcca  atggcaaag  atctccaag  gataagaaa  2040
ccaaaactg  tggttccca  aagactgag  gttcaaccg  aggtaaaga  caagaagag  2100
agtccggtg  agatggtga  aaagacaca  aggatgacc  gacagagca  gaacctaat  2160
tgcttcttg  atctgaaga  gagctactt  tagatgaag  agaagcagc  gcactgcta  2220
aaagtggca  ttcagtggg  gacgagacc  atcttgcta  tttaggtga  gtggcttct  2280
atgggaaaa  ggaaccatc  gataaagct  tgaaaaaag  tggaagtgc  tcagcagca  2340
caaagaaaa  gcttaaaaa  gtggacaag  tcgaggaac  tgatcaaga  aacgaagca  2400
cgttggaaa  tggaattaa  aatgaggaa  acacagaac  aggtgctga  tcttctgag  2460
acgctgatg  tcccaacaa  gatacaagt  aaaacgcag  tggtcaaag  gatgagaac  2520
aggacgact  tacaatccc  gatgagtat  gaattggac  atatcagcc  aatgttcct  2580
ttggtatag  ctatgtgat  cctaaaaca  ggttttact  taagctgtg  tcactcttt  2640
atacaaatg  agaagttgc  aagaatact  attgcagca  ccttcctca  tatcagaaa  2700
taaagaaat  tctgaataa  ttggcagaa  aacgcagac  gaagaagga  acttaagat  2760
tgcaaggag  tttaatgat  tcaaagaaa  taatggttc  ttgttttta  tgttaacct  2820
ttttaaata  aatactgat  gttagaaga  aactattgt  ctcttttgt  ttagtggag  2880
aataataga  gtctgttca  gtgttaagt  ttatagcaa  aaaaataca  atatggtta  2940
gttaatgaa  agtttttgt  ttatcagaa  ggcaacaga  agaagtact  tgtagagat  3000
gacttccta  gctacttaa  acaacttgc  ccactaaga  aaaaatgta  aaccatttg  3060
aaaaatgaa  tttagtagt  ccaagtttc  aagaaatgt  aacatttta  tccattcaa  3120
aaagaacaa  accaatagt  tttttatta  tttcatctg  aacattcca  gttttaatc  3180
gagccttgc  gactttcat  tggagtttg  acccgtttt  gttgcattt  atttttgga  3240
aacttaatt  acgtgagat  ggcaattga  atgcaggtg  agttttctg  taatgtcat  3300
ctgttgttt  ggtaataag  aatattaag  aattggctt  agattttgt  atttttttc  3360
ctgagttcc  gctagattt  gtattctag  agtcaatgt  ttttcagtg  aatgcaaaa  3420
tattcccat  atctttgac  agtattaat  tttgagatc  tactgcttg  cacttgaat  3480
ccgtgattg  catacatct  tggtataag  aacatttga  ttttgaagt  tgtagacca  3540
ctcttcata  tttcaagat  taattttac  tttctgcat  tttaaaaca  tttggccat  3600
atcctagat  cacgcttct  attcatgta  ctgcacatg  gacctttgt  aacagaaat  3660
tgcatgtat  atttgtgtt  acttgtaac  ttctggtta  atactgctt  tatctgtgg  3720
ttcaagtta  tgaagtgaa  accaataaa  agaaaaccc  aggccatgt  aattggtta  3780
acatgtttg  aatgttaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  3828



<210> 3799
<211> 847
<212> PRT
<213> Homo sapiens
<308> P43243
<400> 3799

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
  1               5                  10                  15
His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
             20                  25                  30
Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
         35                  40                  45
Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
     50                  55                  60
Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
 65                  70                  75                  80
His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                 85                  90                  95
Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln Ala Ser Asn Ile Leu 
             100                105                110
Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp Glu Leu Ser Arg Tyr 
         115                120                125
Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln Ile Leu Leu Gln 
     130                135                140
Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr Leu Ser Tyr Gly Arg 
 145                150                155                160
Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr Arg Val Pro Arg Asp 
                 165                170                175
Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser Phe Asp Asp Arg 
             180                185                190
Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp His Gly Ser Arg Ser 
         195                200                205
Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu Asp Asp Arg Leu 
     210                215                220
Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser 
 225                230                235                240
His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg Met Gly Arg Gly 
                 245                250                255
Pro Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys Lys Arg Gly Ala 
             260                265                270
Pro Pro Ser Ser Asn Ile Glu Asp Phe His Gly Leu Leu Pro Lys Gly 
         275                280                285
Tyr Pro His Leu Cys Ser Ile Cys Asp Leu Pro Val His Ser Asn Lys 
     290                295                300
Glu Trp Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln 
 305                310                315                320
Leu Leu Leu Glu Ile Tyr Pro Glu Trp Asn Pro Asp Asn Asp Thr Gly 
                 325                330                335
His Thr Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala 
             340                345                350
Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro 
         355                360                365
Ala Val Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln 
     370                375                380
Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val 
 385                390                395                400
His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu 
                 405                410                415
Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn 
             420                425                430
Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln 
         435                440                445
Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys 
     450                455                460
Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro 
 465                470                475                480
Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg 
                 485                490                495
Val Ile His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala 
             500                505                510
Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu 
         515                520                525
Met Arg Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp 
     530                535                540
Ala Met Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln 
 545                550                555                560
Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val 
                 565                570                575
Leu Arg Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser 
             580                585                590
Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser Asp Lys 
         595                600                605
Lys Ser Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr Glu Gly 
     610                615                620
Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp Thr Lys 
 625                630                635                640
Asp Asp Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser Glu Asp 
                 645                650                655
Glu Leu Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly 
             660                665                670
Ser Ser Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ala 
         675                680                685
Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly 
     690                695                700
Ser Ala Ser Ala Ala Ala Lys Lys Lys Leu Lys Lys Val Asp Lys Ile 
 705                710                715                720
Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys 
                 725                730                735
Asn Glu Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp 
             740                745                750
Asp Pro Asn Lys Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu 
         755                760                765
Asn Lys Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr 
     770                775                780
Gln Pro Asn Val Pro Val Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly 
 785                790                795                800
Phe Tyr Cys Lys Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu Val Ala 
                 805                810                815
Lys Asn Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys 
             820                825                830
Phe Leu Asn Lys Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu Thr 
         835                840                845



<210> 3800
<211> 1107
<212> DNA
<213> Rattus norvegicus
<308> M63901
<400> 3800

attgctaga  gctcgcccg  ggccacacg  ttaaaaatg  cctcaagga  ggccatact  60
tctggtctt  tgttttggc  gctgcttga  tggaatcca  cattcgctt  tagtccacg  120
actcctgac  gggtctcag  gacagacat  cagaggctg  tgcatggag  catggagca  180
ctgggcatt  ccaggccac  tgtggagta  ccagcccac  aggccatga  tcttgttgg  240
ccgcagagc  tcgaagggg  agctcacga  ggtcttcag  atctgggtc  tttcggcaa  300
atccccaac  tcgtggcag  gttgactgg  gacaatatt  ctaaggact  cagtgagga  360
caaggctac  cagaccctc  aaatccctg  cctcttggg  aaactgcag  tgacggatg  420
ctagaaaac  cccctgaca  tgcagagtt  agccgagaa  tccagttag  ccagcacct  480
tttgatcca  aacatgact  cccaggttt  ggcaagtgg  acaagaaac  cctttatga  540
aagatgaag  gaggacaga  gcggaagcg  aggagtgtc  atccctatc  acaaggaaa  600
aggctggac  atgttgtgg  aaagaaatc  gtcccccac  tctcagaag  ggagaagga  660
ccagaataa  gagaagaca  taggtggaa  cccatacaa  gcttatgta  gtgcatgtt  720
gcagagccc  tgagtgaca  catgcattt  acatattta  ggatgaaaa  cagctgtcc  780
tgtctccat  gcaatgcct  agctttctg  taaattaga  taaaagctc  tttcctttt  840
gggattttt  gatgtggat  tgcaagaaa  attacaatt  aaatgtata  gtcaagtat  900
ataaaaaca  ggatatgaa  tactctgat  tcttgccgt  ttgggttgt  ctgtttggg  960
caagtctgt  aaaagctag  atttgattt  gattatgta  tctatctag  ccttgggcc  1020
tgttacaca  caataaaga  gtttgtact  aaggggagg  gctgacaca  ctcactctg  1080
tgcttctta  taaatgtat  tgcaagc  1107



<210> 3801
<211> 210
<212> PRT
<213> Rattus norvegicus
<308> P27682
<400> 3801

Met Thr Ser Arg Met Ala Ile Leu Ser Gly Leu Leu Phe Trp Leu Leu 
  1               5                  10                  15
Leu Glu Trp Asn Pro Ala Phe Ala Tyr Ser Pro Arg Thr Pro Asp Arg 
             20                  25                  30
Val Ser Glu Thr Asp Ile Gln Arg Leu Leu His Gly Val Met Glu Gln 
         35                  40                  45
Leu Gly Ile Ala Arg Pro Arg Val Glu Tyr Pro Ala His Gln Ala Met 
     50                  55                  60
Asn Leu Val Gly Pro Gln Ser Ile Glu Gly Gly Ala His Glu Gly Leu 
 65                  70                  75                  80
Gln His Leu Gly Pro Phe Gly Asn Ile Pro Asn Ile Val Ala Glu Leu 
                 85                  90                  95
Thr Gly Asp Asn Ile Pro Lys Asp Phe Ser Glu Asp Gln Gly Tyr Pro 
             100                105                110
Asp Pro Pro Asn Pro Cys Pro Leu Gly Lys Thr Ala Asp Asp Gly Cys 
         115                120                125
Leu Glu Asn Ala Pro Asp Thr Ala Glu Phe Ser Arg Glu Phe Gln Leu 
     130                135                140
Asp Gln His Leu Phe Asp Pro Glu His Asp Tyr Pro Gly Leu Gly Lys 
 145                150                155                160
Trp Asn Lys Lys Leu Leu Tyr Glu Lys Met Lys Gly Gly Gln Arg Arg 
                 165                170                175
Lys Arg Arg Ser Val Asn Pro Tyr Leu Gln Gly Lys Arg Leu Asp Asn 
             180                185                190
Val Val Ala Lys Lys Ser Val Pro His Phe Ser Glu Glu Glu Lys Glu 
         195                200                205
Pro Glu 
     210



<210> 3802
<211> 1210
<212> DNA
<213> Homo sapiens
<308> BC005349
<400> 3802

gacccccac  aaggcccat  ccgcagtag  ctcctcggg  tgcccctcg  ttgacaatg  60
tctccagga  ggtctctac  atgctatct  gcctactgt  ttggctggc  tctggatgg  120
ctccagcat  tgcttacag  ccccggacc  ctgaccggg  ctcagaagc  gatatccag  180
ggctgcttc  tggtgttat  gagcaattg  gcattgcca  gccccgagt  gaatatcca  240
ctcaccagg  catgaatct  gtgggcccc  agagcattg  aggtggagc  catgaagga  300
ttcagcatt  gggtccttt  ggcaacatc  ccaacatcg  ggcagagtt  actggagac  360
acattccta  ggactttag  gaggatcag  ggtacccag  ccctccaaa  ccctgtcct  420
ttggaaaaa  agcagatga  ggatgtcta  aaaacaccc  tgacactgc  gagttcagt  480
gagagttcc  gttgcacca  catctctct  atccggaac  tgactatcc  ggcttgggc  540
agtggaaca  gaaactcct  tacgagaag  tgaagggag  agagagacg  aagcggagg  600
gtgtcaatc  atatctaca  ggacagaga  tggataatg  tgttgcaaa  aagtctgtc  660
cccattttt  agatgagga  aaggatcca  agtaaagag  agatgctag  cgaaaaccc  720
cattacctg  taggcctca  catggctta  gtgcacgtg  aaatggagt  cctgtgaat  780
acagcatgt  tcttacata  ataattatg  atacaaagc  gctgtatgt  gatagtgta  840
tgtcttcac  ccgatgatt  tgctttttg  taaattaga  taagagctt  tttgtttct  900
gggttttta  aatgtgaat  tgcaatgat  ataaaaatt  aaatgtgaa  gtcaacaat  960
aaaagcaag  ctatgaaag  ctcagattt  ttgcagttt  aaatggtgt  tgaggttgt  1020
ctattttgg  caagtctgt  gaaagctgt  atttgattt  gattatgta  ttcatccag  1080
ccttgggca  tgttataca  cagtaaaga  ggctgtact  aagaggagg  gctgacaca  1140
ttcacttgg  tgcgtctta  taaacatga  tgcaagcac  aaaaaaaaa  aaaaaaaaa  1200
aaaaaaaaaa  1210



<210> 3803
<211> 211
<212> PRT
<213> Homo sapiens
<308> P05408
<400> 3803

Met Val Ser Arg Met Val Ser Thr Met Leu Ser Gly Leu Leu Phe Trp 
  1               5                  10                  15
Leu Ala Ser Gly Trp Thr Pro Ala Phe Ala Tyr Ser Pro Arg Thr Pro 
             20                  25                  30
Asp Arg Val Ser Glu Ala Asp Ile Gln Arg Leu Leu His Gly Val Met 
         35                  40                  45
Glu Gln Leu Gly Ile Ala Arg Pro Arg Val Glu Tyr Pro Ala His Gln 
     50                  55                  60
Ala Met Asn Leu Val Gly Pro Gln Ser Ile Glu Gly Gly Ala His Glu 
 65                  70                  75                  80
Gly Leu Gln His Leu Gly Pro Phe Gly Asn Ile Pro Asn Ile Val Ala 
                 85                  90                  95
Glu Leu Thr Gly Asp Asn Ile Pro Lys Asp Phe Ser Glu Asp Gln Gly 
             100                105                110
Tyr Pro Asp Pro Pro Asn Pro Cys Pro Val Gly Lys Thr Asp Asp Gly 
         115                120                125
Cys Leu Glu Asn Thr Pro Asp Thr Ala Glu Phe Ser Arg Glu Phe Gln 
     130                135                140
Leu His Gln His Leu Phe Asp Pro Glu His Asp Tyr Pro Gly Leu Gly 
 145                150                155                160
Lys Trp Asn Lys Lys Leu Leu Tyr Glu Lys Met Lys Gly Gly Glu Arg 
                 165                170                175
Arg Lys Arg Arg Ser Val Asn Pro Tyr Leu Gln Gly Gln Arg Leu Asp 
             180                185                190
Asn Val Val Ala Lys Lys Ser Val Pro His Phe Ser Asp Glu Asp Lys 
         195                200                205
Asp Pro Glu 
     210



<210> 3804
<211> 1107
<212> DNA
<213> Rattus norvegicus
<308> M63901
<400> 3804

attgctaga  gctcgcccg  ggccacacg  ttaaaaatg  cctcaagga  ggccatact  60
tctggtctt  tgttttggc  gctgcttga  tggaatcca  cattcgctt  tagtccacg  120
actcctgac  gggtctcag  gacagacat  cagaggctg  tgcatggag  catggagca  180
ctgggcatt  ccaggccac  tgtggagta  ccagcccac  aggccatga  tcttgttgg  240
ccgcagagc  tcgaagggg  agctcacga  ggtcttcag  atctgggtc  tttcggcaa  300
atccccaac  tcgtggcag  gttgactgg  gacaatatt  ctaaggact  cagtgagga  360
caaggctac  cagaccctc  aaatccctg  cctcttggg  aaactgcag  tgacggatg  420
ctagaaaac  cccctgaca  tgcagagtt  agccgagaa  tccagttag  ccagcacct  480
tttgatcca  aacatgact  cccaggttt  ggcaagtgg  acaagaaac  cctttatga  540
aagatgaag  gaggacaga  gcggaagcg  aggagtgtc  atccctatc  acaaggaaa  600
aggctggac  atgttgtgg  aaagaaatc  gtcccccac  tctcagaag  ggagaagga  660
ccagaataa  gagaagaca  taggtggaa  cccatacaa  gcttatgta  gtgcatgtt  720
gcagagccc  tgagtgaca  catgcattt  acatattta  ggatgaaaa  cagctgtcc  780
tgtctccat  gcaatgcct  agctttctg  taaattaga  taaaagctc  tttcctttt  840
gggattttt  gatgtggat  tgcaagaaa  attacaatt  aaatgtata  gtcaagtat  900
ataaaaaca  ggatatgaa  tactctgat  tcttgccgt  ttgggttgt  ctgtttggg  960
caagtctgt  aaaagctag  atttgattt  gattatgta  tctatctag  ccttgggcc  1020
tgttacaca  caataaaga  gtttgtact  aaggggagg  gctgacaca  ctcactctg  1080
tgcttctta  taaatgtat  tgcaagc  1107



<210> 3805
<211> 210
<212> PRT
<213> Rattus norvegicus
<308> P27682
<400> 3805

Met Thr Ser Arg Met Ala Ile Leu Ser Gly Leu Leu Phe Trp Leu Leu 
  1               5                  10                  15
Leu Glu Trp Asn Pro Ala Phe Ala Tyr Ser Pro Arg Thr Pro Asp Arg 
             20                  25                  30
Val Ser Glu Thr Asp Ile Gln Arg Leu Leu His Gly Val Met Glu Gln 
         35                  40                  45
Leu Gly Ile Ala Arg Pro Arg Val Glu Tyr Pro Ala His Gln Ala Met 
     50                  55                  60
Asn Leu Val Gly Pro Gln Ser Ile Glu Gly Gly Ala His Glu Gly Leu 
 65                  70                  75                  80
Gln His Leu Gly Pro Phe Gly Asn Ile Pro Asn Ile Val Ala Glu Leu 
                 85                  90                  95
Thr Gly Asp Asn Ile Pro Lys Asp Phe Ser Glu Asp Gln Gly Tyr Pro 
             100                105                110
Asp Pro Pro Asn Pro Cys Pro Leu Gly Lys Thr Ala Asp Asp Gly Cys 
         115                120                125
Leu Glu Asn Ala Pro Asp Thr Ala Glu Phe Ser Arg Glu Phe Gln Leu 
     130                135                140
Asp Gln His Leu Phe Asp Pro Glu His Asp Tyr Pro Gly Leu Gly Lys 
 145                150                155                160
Trp Asn Lys Lys Leu Leu Tyr Glu Lys Met Lys Gly Gly Gln Arg Arg 
                 165                170                175
Lys Arg Arg Ser Val Asn Pro Tyr Leu Gln Gly Lys Arg Leu Asp Asn 
             180                185                190
Val Val Ala Lys Lys Ser Val Pro His Phe Ser Glu Glu Glu Lys Glu 
         195                200                205
Pro Glu 
     210



<210> 3806
<211> 1210
<212> DNA
<213> Homo sapiens
<308> BC005349
<400> 3806

gacccccac  aaggcccat  ccgcagtag  ctcctcggg  tgcccctcg  ttgacaatg  60
tctccagga  ggtctctac  atgctatct  gcctactgt  ttggctggc  tctggatgg  120
ctccagcat  tgcttacag  ccccggacc  ctgaccggg  ctcagaagc  gatatccag  180
ggctgcttc  tggtgttat  gagcaattg  gcattgcca  gccccgagt  gaatatcca  240
ctcaccagg  catgaatct  gtgggcccc  agagcattg  aggtggagc  catgaagga  300
ttcagcatt  gggtccttt  ggcaacatc  ccaacatcg  ggcagagtt  actggagac  360
acattccta  ggactttag  gaggatcag  ggtacccag  ccctccaaa  ccctgtcct  420
ttggaaaaa  agcagatga  ggatgtcta  aaaacaccc  tgacactgc  gagttcagt  480
gagagttcc  gttgcacca  catctctct  atccggaac  tgactatcc  ggcttgggc  540
agtggaaca  gaaactcct  tacgagaag  tgaagggag  agagagacg  aagcggagg  600
gtgtcaatc  atatctaca  ggacagaga  tggataatg  tgttgcaaa  aagtctgtc  660
cccattttt  agatgagga  aaggatcca  agtaaagag  agatgctag  cgaaaaccc  720
cattacctg  taggcctca  catggctta  gtgcacgtg  aaatggagt  cctgtgaat  780
acagcatgt  tcttacata  ataattatg  atacaaagc  gctgtatgt  gatagtgta  840
tgtcttcac  ccgatgatt  tgctttttg  taaattaga  taagagctt  tttgtttct  900
gggttttta  aatgtgaat  tgcaatgat  ataaaaatt  aaatgtgaa  gtcaacaat  960
aaaagcaag  ctatgaaag  ctcagattt  ttgcagttt  aaatggtgt  tgaggttgt  1020
ctattttgg  caagtctgt  gaaagctgt  atttgattt  gattatgta  ttcatccag  1080
ccttgggca  tgttataca  cagtaaaga  ggctgtact  aagaggagg  gctgacaca  1140
ttcacttgg  tgcgtctta  taaacatga  tgcaagcac  aaaaaaaaa  aaaaaaaaa  1200
aaaaaaaaaa  1210



<210> 3807
<211> 211
<212> PRT
<213> Homo sapiens
<308> P05408
<400> 3807

Met Val Ser Arg Met Val Ser Thr Met Leu Ser Gly Leu Leu Phe Trp 
  1               5                  10                  15
Leu Ala Ser Gly Trp Thr Pro Ala Phe Ala Tyr Ser Pro Arg Thr Pro 
             20                  25                  30
Asp Arg Val Ser Glu Ala Asp Ile Gln Arg Leu Leu His Gly Val Met 
         35                  40                  45
Glu Gln Leu Gly Ile Ala Arg Pro Arg Val Glu Tyr Pro Ala His Gln 
     50                  55                  60
Ala Met Asn Leu Val Gly Pro Gln Ser Ile Glu Gly Gly Ala His Glu 
 65                  70                  75                  80
Gly Leu Gln His Leu Gly Pro Phe Gly Asn Ile Pro Asn Ile Val Ala 
                 85                  90                  95
Glu Leu Thr Gly Asp Asn Ile Pro Lys Asp Phe Ser Glu Asp Gln Gly 
             100                105                110
Tyr Pro Asp Pro Pro Asn Pro Cys Pro Val Gly Lys Thr Asp Asp Gly 
         115                120                125
Cys Leu Glu Asn Thr Pro Asp Thr Ala Glu Phe Ser Arg Glu Phe Gln 
     130                135                140
Leu His Gln His Leu Phe Asp Pro Glu His Asp Tyr Pro Gly Leu Gly 
 145                150                155                160
Lys Trp Asn Lys Lys Leu Leu Tyr Glu Lys Met Lys Gly Gly Glu Arg 
                 165                170                175
Arg Lys Arg Arg Ser Val Asn Pro Tyr Leu Gln Gly Gln Arg Leu Asp 
             180                185                190
Asn Val Val Ala Lys Lys Ser Val Pro His Phe Ser Asp Glu Asp Lys 
         195                200                205
Asp Pro Glu 
     210



<210> 3808
<211> 853
<212> DNA
<213> Rattus norvegicus
<308> M63983
<400> 3808

ggcacgagg  acttacctc  ctgcttttc  tagcggtac  acctcctcc  ccagcttcc  60
cctcagacc  cttttcccg  gagccgacc  gttctgtca  gtcgaccct  agtcccagc  120
tcgtgatta  tgatgatga  ccaggttat  acctagatt  attttgcat  cctaatcat  180
atgctgaag  tttggaaaa  gtgtttatt  ctcatggac  gattatgga  aggactgaa  240
gacttgctc  agatgtcat  aaggagatg  gaggccatc  cattgtggc  ctctgtgtg  300
tgaaggggg  ctataagtt  tttgctgac  tgctggatt  cattaaagc  ctgaataga  360
atagtgata  gtccattcc  atgactgta  attttatca  actgaagag  tactgtaat  420
accagtcaa  gggggacat  aaagttatt  gtggagatg  tctctcaac  ttaactgga  480
agaacgtct  gattgttga  gatataatt  acactggta  aacaatgca  actttgctt  540
ccttggtca  gcagtacag  cccaaaatg  ttaaggttg  aagcttgct  gtgaaaagg  600
cctctcgaa  tgttggata  aggccagac  ttgttggat  tgaaattcc  gacaagttt  660
ttgttggat  tgcccttga  tataatgag  acttcaggg  tttgaatca  gtttgtgtc  720
tcagcgaaa  tggaaaagc  aagtacaaa  cctaaaaga  agcggcaag  tgaatctac  780
agagtcctg  tgatgtggc  agtaaagaa  tagcagacg  tctagtcct  tggccatct  840
cttagtaaa  ctt  853



<210> 3809
<211> 218
<212> PRT
<213> Rattus norvegicus
<308> P27605
<400> 3809

Met Ser Thr Leu Ser Pro Ser Val Val Ile Ser Asp Asp Glu Pro Gly 
  1               5                  10                  15
Tyr Asp Leu Asp Leu Phe Cys Ile Pro Asn His Tyr Ala Glu Asp Leu 
             20                  25                  30
Glu Lys Val Phe Ile Pro His Gly Leu Ile Met Asp Arg Thr Glu Arg 
         35                  40                  45
Leu Ala Arg Asp Val Met Lys Glu Met Gly Gly His His Ile Val Ala 
     50                  55                  60
Leu Cys Val Leu Lys Gly Gly Tyr Lys Phe Phe Ala Asp Leu Leu Asp 
 65                  70                  75                  80
Tyr Ile Lys Ala Leu Asn Arg Asn Ser Asp Arg Ser Ile Pro Met Thr 
                 85                  90                  95
Val Asp Phe Ile Arg Leu Lys Ser Tyr Cys Asn Asp Gln Ser Thr Gly 
             100                105                110
Asp Ile Lys Val Ile Gly Gly Asp Asp Leu Ser Thr Leu Thr Gly Lys 
         115                120                125
Asn Val Leu Ile Val Glu Asp Ile Ile Asp Thr Gly Lys Thr Met Gln 
     130                135                140
Thr Leu Leu Ser Leu Val Lys Gln Tyr Ser Pro Lys Met Val Lys Val 
 145                150                155                160
Ala Ser Leu Leu Val Lys Arg Thr Ser Arg Ser Val Gly Tyr Arg Pro 
                 165                170                175
Asp Phe Val Gly Phe Glu Ile Pro Asp Lys Phe Val Val Gly Tyr Ala 
             180                185                190
Leu Asp Tyr Asn Glu His Phe Arg Asp Leu Asn His Val Cys Val Ile 
         195                200                205
Ser Glu Ser Gly Lys Ala Lys Tyr Lys Ala 
     210                215



<210> 3810
<211> 654
<212> DNA
<213> Homo sapiens
<308> L29382
<400> 3810

atggcgacc  gcagccctg  cgtcgtgat  agtgatgat  aaccaggtt  tgaccttga  60
ttattttgc  tacctaatc  ttatgctga  gatttggaa  gggtgttta  tcctcatgg  120
ctaattatg  acaggactg  acgtcttgc  cgagatgtg  tgaaggaga  gggaggcca  180
cacattgta  ccctctgtg  gctcaaggg  ggctataaa  tctttgctg  cctgctgga  240
tacatcaaa  cactgaata  aaatagtga  agatccatt  ctatgactg  agattttat  300
agactgaag  gctattgta  tgaccagtc  acaggggac  taaaagtaa  tggtggaga  360
gatctctca  ctttaactg  aaagaatgt  ttgattgtg  aagatataa  tgacactgg  420
aaaacaatg  agactttgc  ttccttggt  aggcagtat  atccaaaga  ggtcaaggt  480
gcaagcttg  tggtgaaaa  gaccccacg  agtgttgga  ataagccag  ctttgttgg  540
tttgaaatt  cagacaagt  tgttgtagg  tatgccctt  agtataatg  atacttcag  600
gatttgaat  atgtttgtg  cattagtga  actggaaaa  caaaataca  agcc  654



<210> 3811
<211> 217
<212> PRT
<213> Homo sapiens
<308> AAB59392
<400> 3811

Ala Thr Arg Ser Pro Gly Val Val Ile Ser Asp Asp Glu Pro Gly Tyr 
  1               5                  10                  15
Asp Leu Asp Leu Phe Cys Ile Pro Asn His Tyr Ala Glu Asp Leu Glu 
             20                  25                  30
Arg Val Phe Ile Pro His Gly Leu Ile Met Asp Arg Thr Glu Arg Leu 
         35                  40                  45
Ala Arg Asp Val Met Lys Glu Met Gly Gly His His Ile Val Ala Leu 
     50                  55                  60
Cys Val Leu Lys Gly Gly Tyr Lys Phe Phe Ala Asp Leu Leu Asp Tyr 
 65                  70                  75                  80
Ile Lys Ala Leu Asn Arg Asn Ser Asp Arg Ser Ile Pro Met Thr Val 
                 85                  90                  95
Asp Phe Ile Arg Leu Lys Ser Tyr Cys Asn Asp Gln Ser Thr Gly Asp 
             100                105                110
Ile Lys Val Ile Gly Gly Asp Asp Leu Ser Thr Leu Thr Gly Lys Asn 
         115                120                125
Val Leu Ile Val Glu Asp Ile Ile Asp Thr Gly Lys Thr Met Gln Thr 
     130                135                140
Leu Leu Ser Leu Val Arg Gln Tyr Asn Pro Lys Met Val Lys Val Ala 
 145                150                155                160
Ser Leu Leu Val Lys Arg Thr Pro Arg Ser Val Gly Tyr Lys Pro Asp 
                 165                170                175
Phe Val Gly Phe Glu Ile Pro Asp Lys Phe Val Val Gly Tyr Ala Leu 
             180                185                190
Asp Tyr Asn Glu Tyr Phe Arg Asp Leu Asn His Val Cys Val Ile Ser 
         195                200                205
Glu Thr Gly Lys Ala Lys Tyr Lys Ala 
     210                215



<210> 3812
<211> 853
<212> DNA
<213> Rattus norvegicus
<308> M63983
<400> 3812

ggcacgagg  acttacctc  ctgcttttc  tagcggtac  acctcctcc  ccagcttcc  60
cctcagacc  cttttcccg  gagccgacc  gttctgtca  gtcgaccct  agtcccagc  120
tcgtgatta  tgatgatga  ccaggttat  acctagatt  attttgcat  cctaatcat  180
atgctgaag  tttggaaaa  gtgtttatt  ctcatggac  gattatgga  aggactgaa  240
gacttgctc  agatgtcat  aaggagatg  gaggccatc  cattgtggc  ctctgtgtg  300
tgaaggggg  ctataagtt  tttgctgac  tgctggatt  cattaaagc  ctgaataga  360
atagtgata  gtccattcc  atgactgta  attttatca  actgaagag  tactgtaat  420
accagtcaa  gggggacat  aaagttatt  gtggagatg  tctctcaac  ttaactgga  480
agaacgtct  gattgttga  gatataatt  acactggta  aacaatgca  actttgctt  540
ccttggtca  gcagtacag  cccaaaatg  ttaaggttg  aagcttgct  gtgaaaagg  600
cctctcgaa  tgttggata  aggccagac  ttgttggat  tgaaattcc  gacaagttt  660
ttgttggat  tgcccttga  tataatgag  acttcaggg  tttgaatca  gtttgtgtc  720
tcagcgaaa  tggaaaagc  aagtacaaa  cctaaaaga  agcggcaag  tgaatctac  780
agagtcctg  tgatgtggc  agtaaagaa  tagcagacg  tctagtcct  tggccatct  840
cttagtaaa  ctt  853



<210> 3813
<211> 218
<212> PRT
<213> Rattus norvegicus
<308> P27605
<400> 3813

Met Ser Thr Leu Ser Pro Ser Val Val Ile Ser Asp Asp Glu Pro Gly 
  1               5                  10                  15
Tyr Asp Leu Asp Leu Phe Cys Ile Pro Asn His Tyr Ala Glu Asp Leu 
             20                  25                  30
Glu Lys Val Phe Ile Pro His Gly Leu Ile Met Asp Arg Thr Glu Arg 
         35                  40                  45
Leu Ala Arg Asp Val Met Lys Glu Met Gly Gly His His Ile Val Ala 
     50                  55                  60
Leu Cys Val Leu Lys Gly Gly Tyr Lys Phe Phe Ala Asp Leu Leu Asp 
 65                  70                  75                  80
Tyr Ile Lys Ala Leu Asn Arg Asn Ser Asp Arg Ser Ile Pro Met Thr 
                 85                  90                  95
Val Asp Phe Ile Arg Leu Lys Ser Tyr Cys Asn Asp Gln Ser Thr Gly 
             100                105                110
Asp Ile Lys Val Ile Gly Gly Asp Asp Leu Ser Thr Leu Thr Gly Lys 
         115                120                125
Asn Val Leu Ile Val Glu Asp Ile Ile Asp Thr Gly Lys Thr Met Gln 
     130                135                140
Thr Leu Leu Ser Leu Val Lys Gln Tyr Ser Pro Lys Met Val Lys Val 
 145                150                155                160
Ala Ser Leu Leu Val Lys Arg Thr Ser Arg Ser Val Gly Tyr Arg Pro 
                 165                170                175
Asp Phe Val Gly Phe Glu Ile Pro Asp Lys Phe Val Val Gly Tyr Ala 
             180                185                190
Leu Asp Tyr Asn Glu His Phe Arg Asp Leu Asn His Val Cys Val Ile 
         195                200                205
Ser Glu Ser Gly Lys Ala Lys Tyr Lys Ala 
     210                215



<210> 3814
<211> 1331
<212> DNA
<213> Homo sapiens
<308> NM_000194
<400> 3814

tcttgctgc  cctccgcct  ctcctctgc  ccgccaccg  cttcctcct  ctgagcagt  60
agcccgcgc  ccggccggc  ccgttatgg  gacccgcag  cctggcgtc  tgattagtg  120
tgatgaacc  ggttatgac  ttgatttat  ttgcatacc  aatcattat  ctgaggatt  180
ggaaagggt  tttattcct  atggactaa  tatggacag  actgaacgt  ttgctcgag  240
tgtgatgaa  gagatggga  gccatcaca  tgtagccct  tgtgtgctc  aggggggct  300
taaattctt  gctgacctg  tggattaca  caaagcact  aatagaaat  gtgatagat  360
cattcctat  actgtagat  ttatcagac  gaagagcta  tgtaatgac  agtcaacag  420
ggacataaa  gtaattggt  gagatgatc  ctcaacttt  actggaaag  atgtcttga  480
tgtggaaga  ataattgac  ctggcaaaa  aatgcagac  ttgctttcc  tggtcaggc  540
gtataatcc  aagatggtc  aggtcgcaa  cttgctggt  aaaaggacc  cacgaagtg  600
tggatataa  ccagacttt  ttggatttg  aattccaga  aagtttgtt  taggatatg  660
ccttgacta  aatgaatac  tcagggatt  gaatcatgt  tgtgtcatt  gtgaaactg  720
aaaagcaaa  tacaaagcc  aagatgaga  ttcaagttg  gtttggaaa  atctggagt  780
ctattgaca  cgccagtaa  attatcaat  ttctagttc  gtggccatc  gcttagtag  840
gctttttgc  tgtatcttc  aagaatttt  tctgttttg  actttagaa  tgtcagttg  900
tgcattcct  aactgttta  ttgcactat  agcctatag  ctatcagtt  cctttgggc  960
gattgttgt  taacttgta  atgaaaaaa  tctcttaaa  cacagcact  ttgagtgaa  1020
cattgaact  atatctgta  gaaataaag  gaagatata  tagtttttt  attggtatt  1080
taattttta  atatgcagg  aagaataga  gtgattgaa  attgttaat  ataccaccg  1140
gtgttagaa  agtaagaag  agtcaattt  cacatcaaa  acagcatct  agaagtttt  1200
ttctgtcct  gaattattt  agtagtgtt  cagtaatgt  gactgtatt  tccaacttg  1260
tcaaattat  accagtgaa  ctttgtcag  agttccctt  taaatgcaa  tcaataaat  1320
cccaaaaat  t  1331



<210> 3815
<211> 217
<212> PRT
<213> Homo sapiens
<308> P00492
<400> 3815

Ala Thr Arg Ser Pro Gly Val Val Ile Ser Asp Asp Glu Pro Gly Tyr 
  1               5                  10                  15
Asp Leu Asp Leu Phe Cys Ile Pro Asn His Tyr Ala Glu Asp Leu Glu 
             20                  25                  30
Arg Val Phe Ile Pro His Gly Leu Ile Met Asp Arg Thr Glu Arg Leu 
         35                  40                  45
Ala Arg Asp Val Met Lys Glu Met Gly Gly His His Ile Val Ala Leu 
     50                  55                  60
Cys Val Leu Lys Gly Gly Tyr Lys Phe Phe Ala Asp Leu Leu Asp Tyr 
 65                  70                  75                  80
Ile Lys Ala Leu Asn Arg Asn Ser Asp Arg Ser Ile Pro Met Thr Val 
                 85                  90                  95
Asp Phe Ile Arg Leu Lys Ser Tyr Cys Asn Asp Gln Ser Thr Gly Asp 
             100                105                110
Ile Lys Val Ile Gly Gly Asp Asp Leu Ser Thr Leu Thr Gly Lys Asn 
         115                120                125
Val Leu Ile Val Glu Asp Ile Ile Asp Thr Gly Lys Thr Met Gln Thr 
     130                135                140
Leu Leu Ser Leu Val Arg Gln Tyr Asn Pro Lys Met Val Lys Val Ala 
 145                150                155                160
Ser Leu Leu Val Lys Arg Thr Pro Arg Ser Val Gly Tyr Lys Pro Asp 
                 165                170                175
Phe Val Gly Phe Glu Ile Pro Asp Lys Phe Val Val Gly Tyr Ala Leu 
             180                185                190
Asp Tyr Asn Glu Tyr Phe Arg Asp Leu Asn His Val Cys Val Ile Ser 
         195                200                205
Glu Thr Gly Lys Ala Lys Tyr Lys Ala 
     210                215



<210> 3816
<211> 1350
<212> DNA
<213> Rattus norvegicus
<308> M64092
<400> 3816

ggccggtgg  aggcggcac  gcgagggac  tggcccggc  ccgcaagcg  ctctagcgc  60
cagctgggg  catgatata  tggaaacca  acaagatta  tctggggag  cagaaacca  120
aaagcccct  agactaggt  cggagagga  agataaagg  aagaccccc  ctcagcttc  180
ccctttacc  gtctcagaa  caacagccc  ttttaacca  agatttact  tgtgatgag  240
acagattca  cggagatga  tgatgtgga  tctgtaatc  gcagcttcg  gtcttcagc  300
agggcgggc  gccgcaatg  cttacccga  atccagagt  cactggcta  aggtggatc  360
cctgatctt  cactgaagc  ggaggcatt  gctgtgaag  aagatgcaa  aatgaagaa  420
gaagagaaa  accaaggcc  accgaagaa  cccctagac  aagacaaat  aaggcttag  480
atttatcaa  ggtgttgat  ttatgcaca  tgagagaca  agctatgca  tcctggggt  540
tttgatctg  tagtaacca  ggtaaccca  ggtaacctc  gtgtgtgtg  gtgtgtgtg  600
gtgttttca  taattttgt  atgatgcta  ccttaaact  cagctatga  actgaaata  660
aatattaaa  gttattacc  tcaaattgc  cccaaggaa  gacacactg  ttatatccc  720
acaatatcc  atctgtcta  cgagattta  ttagtcaga  atatgttta  ttctgtctt  780
gcaagttag  acctttttc  tggtatgta  aaatggata  ctattaatt  aatactttg  840
agaatttgt  ggaaattat  tttttggtg  gatagaatt  gtagtaaaa  aatcactct  900
ataaaatgt  tttattttt  attaaaatt  caccatatt  cctgcaaaa  attaggaga  960
atctggaaa  attgtaaaa  ttgtaacaa  ttaaacatc  ctatgatgt  tttgtctaa  1020
gtattttgc  tctagtctc  atgtattgt  atttttaat  tggactcac  taacataaa  1080
tttgtgaca  acttgctta  aagaaacat  tatattgaa  aaatctcac  atattcctt  1140
acttggtta  atgtgtgct  ctcatttta  tatggattg  acaagatat  gtgctcttt  1200
tcttagact  tttgtctct  ggtttttgt  tgtgtacgc  aattgttgc  agagtaatt  1260
catcaggaa  gctggtctt  gtttttata  ttttccaaa  tataatact  taagttaaa  1320
tagcaaaat  aatgctttt  atatatgttt  1350



<210> 3817
<211> 70
<212> PRT
<213> Rattus norvegicus
<308> P27775
<400> 3817

Thr Asp Val Glu Ser Val Ile Ser Ser Phe Ala Ser Ser Ala Arg Ala 
  1               5                  10                  15
Gly Arg Arg Asn Ala Leu Pro Asp Ile Gln Ser Ser Leu Ala Thr Gly 
             20                  25                  30
Gly Ser Pro Asp Leu Ala Leu Lys Leu Glu Ala Leu Ala Val Lys Glu 
         35                  40                  45
Asp Ala Lys Met Lys Asn Glu Glu Lys Asp Gln Gly Gln Pro Lys Lys 
     50                  55                  60
Pro Leu Asp Glu Asp Lys 
 65                  70



<210> 3818
<211> 1057
<212> DNA
<213> Homo sapiens
<308> AF225513
<400> 3818

gggggttat  tttagcaat  tggctcaca  tgagggctt  ctgctctat  cagcaaatg  60
gcaaatgga  gctgcagga  cgtaacagt  gacattgat  aagatgttg  tatgaggac  120
gattcatca  aaatgactg  cgtggagtc  ggggtcgcc  attttgcat  ttcagcaag  180
gcaggccgc  ggaatgcct  accagacat  cagagttca  ctgccacag  cggaacctc  240
gatttgccc  tcaaactgg  ggctctctc  gtgaaggaa  atgcaaaag  gaaagatga  300
aaaacaaca  aagaccaat  ggaaaagcc  caaaatgaa  aaaaatgaa  gctcataat  360
tatcaagag  gctgaattt  tgcatgttg  aagacttag  ggttctgtt  tcttgagac  420
tttaatctg  tggtaactg  ggtaacatt  cagccctaa  cagcatgtg  atattagat  480
attgtgttg  gatgctact  actttgatt  caatgatga  gtccaaggt  agctattaa  540
aggcaggtt  cttccaaat  gcactgaag  aaaaggtta  gaataatac  tgatcacag  600
aatgcatac  actgtctgt  aacccaaca  aattcactg  tctcttttg  atttattta  660
cctgatgta  ttttaattc  atttttatg  tgatgggca  atcattctt  gtaaatgta  720
atcaaacat  attgattta  aacttcatg  aatttgtag  aaattatgg  catttttgg  780
gagaaagaa  aatagtcaa  actcacatg  atagagtgt  tttgttttt  gccaaaaat  840
ccccagacc  tttcccaaa  ctcaaaaac  tcttggaaa  attgtaaaa  tttgataac  900
gaaacatct  taggatatt  ttgtctgac  tattttgct  ctagtatgt  cctactgtg  960
tttttttca  gtggaaaat  caaaatttg  aacaaaatg  ttatatgga  catgcctat  1020
aaacgaatt  tactatctt  cctaaaaaa  aaaaaaa  1057



<210> 3819
<211> 78
<212> PRT
<213> Homo sapiens
<308> Q9C010
<400> 3819

Met Arg Thr Asp Ser Ser Lys Met Thr Asp Val Glu Ser Gly Val Ala 
  1               5                  10                  15
Asn Phe Ala Ser Ser Ala Arg Ala Gly Arg Arg Asn Ala Leu Pro Asp 
             20                  25                  30
Ile Gln Ser Ser Ala Ala Thr Asp Gly Thr Ser Asp Leu Pro Leu Lys 
         35                  40                  45
Leu Glu Ala Leu Ser Val Lys Glu Asp Ala Lys Glu Lys Asp Glu Lys 
     50                  55                  60
Thr Thr Gln Asp Gln Leu Glu Lys Pro Gln Asn Glu Glu Lys 
 65                  70                  75



<210> 3820
<211> 3662
<212> DNA
<213> Rattus norvegicus
<308> M64301
<400> 3820

agacctgcc  ggcgcatat  tattcacag  tttgtccca  gttaagtcg  ttagcatag  60
gaatctgag  gcatagtat  tcatttcat  ccgttgagt  tctcgagtg  tttctttaa  120
tgtctgcag  gtcgctacc  ttccttgaa  tatgaagca  tgcaatctt  ttaattctc  180
gtatgaaga  agatttttg  gctttaagt  tgaggggaa  tcagcaggc  tggttggcg  240
ctgcaatga  catcaagaa  ccatcgtgc  gtgggaatg  gatcgtttt  ctccctttt  300
gagagatct  tccttttga  gccagtttt  ttccttgtt  acacaagtt  aacaatttg  360
aaggaaaag  caattgtaa  ggttttaaa  tggcagaga  atttgaaag  ctcatgaac  420
ttcatggct  tgatctggg  tccaggtac  tggacttaa  accattggg  tgtggaggc  480
atggcttgg  tttttctgc  gtagacaat  actgtgaca  aagagtagc  atcaagaaa  540
ttgtcctca  cgatcccca  agtgtcaaa  atgccctcc  tgaaatcaa  attattaga  600
gacttgacc  cgataacat  gtgaaagtg  ttgaaattc  tggtcccag  ggaagccag  660
tgacagacg  tgtgggctc  ctaacagag  tgaatagcg  ctacattgt  caggagtac  720
tggagacag  cttggcgaa  gtgctggag  agggccctt  actggagga  catgccagg  780
tcttcatgt  ccagctgct  cgtgggctc  agtacatcc  ctctgcaaa  gtgctgcac  840
gggatctca  gccggccaa  cttttcatt  acactgaag  cttggtgct  aagattggt  900
actttggcc  ggcccggat  atggatcct  attattccc  taagggtca  ctttctgaa  960
gattggtta  caaatggta  agatctcca  ggcttttac  ttctcctaa  aactatact  1020
aagccattg  catgtgggc  gcaggctgc  tctttgctg  aatgctgac  ggtaaaacc  1080
tctttgcag  tgcacatga  cttgaacag  tgcagctga  cttggagtc  atccctgtt  1140
tgcacgagg  agatcggca  gagcttctc  gcgtgattc  agtttacat  agaaacgac  1200
tgactgagc  acacaaacc  ctgactcag  tgcttccgg  gattagtcg  gaagcactg  1260
atttcctgg  acagattct  acgttcagt  ccatggacc  gctgacagc  gaggaagca  1320
tttcccatc  ttacatgag  atctactct  tcccaacgg  cgagcctat  tccagccat  1380
ctttccaca  agaagacga  gtggacgac  ttttgctaa  ggatgaaac  cacagtcac  1440
tttataact  ggaaaggta  cacgattgt  agttctcgg  gcatgactg  cctattcat  1500
acaactttg  tatcgatga  gttcagctt  acccgagag  tctgtctga  gtcaccgat  1560
aagaagaag  tcaagttga  cctcgaaag  acttggatg  agaccgaga  aagtatctg  1620
aggatcccg  cttcgacac  agctactct  ctgagcctt  ctggcagta  ccagatcac  1680
acgagaaca  gtactgtga  ctggagtgt  gccacacct  taactacaa  acaaggtcg  1740
catcatact  agataacct  gtgtggagg  agagcgagg  taaccatta  tatgagccc  1800
agcttatta  agatctttc  aactggaaa  agcaaagta  ggacaaatc  gacaagaga  1860
gcaagtcca  gtgtgagag  aacgggttg  tcaagcgca  attgcgctt  aggaagcgt  1920
ccagcagct  gctgagagg  agaggggcc  aggctttga  tttgatgcc  tcatcgcag  1980
caccgttca  ctcagtgcc  agcgtgagt  tgctgacgt  gttgacaag  taaacgact  2040
gaatagctc  gtgtcccag  tagaaatga  aagcctgat  tccaagtca  tcagccgag  2100
aaagcaaga  aagggaagg  ctaacctgg  ccagctggg  gccttgtac  agccctcct  2160
ggagagcca  tttgtgagt  gcggggagg  gtgcttcct  atcagtcag  tttgttgtg  2220
ggtcaggaa  gacgaacac  tggagaagg  gaacactta  accagctat  tggacaagt  2280
ttttagcag  aaggaggat  ctgaaatgc  agaaactga  ccagtggaa  aagggaagc  2340
tggggagag  ggccgtgag  cagggcttc  gagcagcgg  ggggagttt  tcctgagca  2400
gcagctaga  tccataggc  ccccgcagt  ccacagtcc  gggggatcc  cactcaagt  2460
catccaggc  acgttaaca  cttccgcta  gaaatcttc  cctcaaatc  ctcacaaga  2520
atacagcaa  attctgaaa  atctgaact  aacactcag  agacacttc  tttgttctt  2580
atgaaatgt  ttgtgtctt  tttatcact  atgttttaa  tcatttttt  tttacttga  2640
tcagaaggt  tcattaatt  gcaaggatt  ttcttggtt  tcagtttgt  aaacacaga  2700
ttttttcta  atgtgagtt  gttttcatt  gaactggca  gtcgtttgc  cacacacaa  2760
gaatagagc  aaacaatgc  gtgcaggag  agacaagat  cgctaggat  gacagacat  2820
ctcacagac  agtgacctg  ttacaggaa  caaaacctt  ccttgaaac  tacacagtg  2880
gactgtaca  aattgcatg  aaagatcta  ttttttcct  aaacatttt  cattcatta  2940
tattttcaa  tttttcata  tgtacacat  tcttaagac  catgatacc  gcagcaact  3000
aaaacgaat  ccgaatttg  tacacatgt  ttatctacc  caaggtaac  aaagtatgc  3060
ggcgaaacc  aacccaccc  tagtcgtcc  cggcatatg  acttgtatc  agccagcgt  3120
ggccgcagt  accaatgag  ctcgtccgc  atttatcaa  gtcctggtg  tcatccttt  3180
cagtgaagt  ttagataca  cacatctta  ttattttta  caaatcagt  tattttctg  3240
atttaatta  aaaaggtaa  ttagtttaa  tttatttgc  actgccctt  ttcccgttt  3300
gcactatgg  ttgttgcct  ccgagctga  ctgagaagt  agcttgtcc  gaggctgtc  3360
atgtacgtt  agtaaagtg  tcactgtgt  taggaatct  tattttgga  gtgcttgat  3420
tatctacaa  gaaaaaaat  aggaattta  tataaaatg  tcctagaag  cttaatggt  3480
tttattttt  aaaaccttg  aatgttaga  ttgtgtgca  ggaagtgat  aaggtacat  3540
attattgta  tttgaacat  gtacatgat  agccttccc  cacccccgt  tttactgta  3600
gtttttatt  aatgatcta  tccccatcc  taggcaagc  tgaataaaa  taggttaaa  3660
gt  3662



<210> 3821
<211> 720
<212> PRT
<213> Rattus norvegicus
<308> P27704
<400> 3821

Met Ala Glu Lys Phe Glu Ser Leu Met Asn Ile His Gly Phe Asp Leu 
  1               5                  10                  15
Gly Ser Arg Tyr Met Asp Leu Lys Pro Leu Gly Cys Gly Gly Asn Gly 
             20                  25                  30
Leu Val Phe Ser Ala Val Asp Asn Asp Cys Asp Lys Arg Val Ala Ile 
         35                  40                  45
Lys Lys Ile Val Leu Thr Asp Pro Gln Ser Val Lys His Ala Leu Arg 
     50                  55                  60
Glu Ile Lys Ile Ile Arg Arg Leu Asp His Asp Asn Ile Val Lys Val 
 65                  70                  75                  80
Phe Glu Ile Leu Gly Pro Ser Gly Ser Gln Leu Thr Asp Asp Val Gly 
                 85                  90                  95
Ser Leu Thr Glu Leu Asn Ser Val Tyr Ile Val Gln Glu Tyr Met Glu 
             100                105                110
Thr Asp Leu Ala Asn Val Leu Glu Gln Gly Pro Leu Leu Glu Glu His 
         115                120                125
Ala Arg Leu Phe Met Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Ile His 
     130                135                140
Ser Ala Asn Val Leu His Arg Asp Leu Lys Pro Ala Asn Leu Phe Ile 
 145                150                155                160
Asn Thr Glu Asp Leu Val Leu Lys Ile Gly Asp Phe Gly Leu Ala Arg 
                 165                170                175
Ile Met Asp Pro His Tyr Ser His Lys Gly His Leu Ser Glu Gly Leu 
             180                185                190
Val Thr Lys Trp Tyr Arg Ser Pro Arg Leu Leu Leu Ser Pro Asn Asn 
         195                200                205
Tyr Thr Lys Ala Ile Asp Met Trp Ala Ala Gly Cys Ile Phe Ala Glu 
     210                215                220
Met Leu Thr Gly Lys Thr Leu Phe Ala Gly Ala His Glu Leu Glu Gln 
 225                230                235                240
Met Gln Leu Ile Leu Glu Ser Ile Pro Val Val His Glu Glu Asp Arg 
                 245                250                255
Gln Glu Leu Leu Ser Val Ile Pro Val Tyr Ile Arg Asn Asp Met Thr 
             260                265                270
Glu Pro His Lys Pro Leu Thr Gln Leu Leu Pro Gly Ile Ser Arg Glu 
         275                280                285
Ala Leu Asp Phe Leu Glu Gln Ile Leu Thr Phe Ser Pro Met Asp Arg 
     290                295                300
Leu Thr Ala Glu Glu Ala Leu Ser His Pro Tyr Met Ser Ile Tyr Ser 
 305                310                315                320
Phe Pro Thr Asp Glu Pro Ile Ser Ser His Pro Phe His Ile Glu Asp 
                 325                330                335
Glu Val Asp Asp Ile Leu Leu Met Asp Glu Thr His Ser His Ile Tyr 
             340                345                350
Asn Trp Glu Arg Tyr His Asp Cys Gln Phe Ser Glu His Asp Trp Pro 
         355                360                365
Ile His Asn Asn Phe Asp Ile Asp Glu Val Gln Leu Asp Pro Arg Ala 
     370                375                380
Leu Ser Asp Val Thr Asp Glu Glu Glu Val Gln Val Asp Pro Arg Lys 
 385                390                395                400
Tyr Leu Asp Gly Asp Arg Glu Lys Tyr Leu Glu Asp Pro Ala Phe Asp 
                 405                410                415
Thr Ser Tyr Ser Ala Glu Pro Cys Trp Gln Tyr Pro Asp His His Glu 
             420                425                430
Asn Lys Tyr Cys Asp Leu Glu Cys Ser His Thr Cys Asn Tyr Lys Thr 
         435                440                445
Arg Ser Pro Ser Tyr Leu Asp Asn Leu Val Trp Arg Glu Ser Glu Val 
     450                455                460
Asn His Tyr Tyr Glu Pro Lys Leu Ile Ile Asp Leu Ser Asn Trp Lys 
 465                470                475                480
Glu Gln Ser Lys Asp Lys Ser Asp Lys Arg Gly Lys Ser Lys Cys Glu 
                 485                490                495
Arg Asn Gly Leu Val Lys Ala Gln Ile Ala Leu Glu Glu Ala Ser Gln 
             500                505                510
Gln Leu Ala Glu Arg Glu Arg Gly Gln Gly Phe Asp Phe Asp Ala Phe 
         515                520                525
Ile Ala Gly Thr Val Gln Leu Ser Ala Gln Arg Glu Ser Ala Asp Val 
     530                535                540
Val Asp Lys Leu Asn Asp Leu Asn Ser Ser Val Ser Gln Leu Glu Met 
 545                550                555                560
Lys Ser Leu Ile Ser Lys Ser Val Ser Arg Glu Lys Gln Glu Lys Gly 
                 565                570                575
Arg Ala Asn Leu Ala Gln Leu Gly Ala Leu Tyr Gln Pro Ser Trp Glu 
             580                585                590
Ser Gln Phe Val Ser Gly Gly Glu Glu Cys Phe Leu Ile Ser Gln Phe 
         595                600                605
Cys Cys Glu Val Arg Lys Asp Glu His Val Glu Lys Glu Asn Thr Tyr 
     610                615                620
Thr Ser Tyr Leu Asp Lys Phe Phe Ser Arg Lys Glu Asp Ser Glu Met 
 625                630                635                640
Leu Glu Thr Glu Pro Val Glu Glu Gly Lys Arg Gly Glu Arg Gly Arg 
                 645                650                655
Glu Ala Gly Leu Leu Ser Ser Gly Gly Glu Phe Leu Leu Ser Arg Gln 
             660                665                670
Leu Glu Ser Ile Gly Thr Pro Gln Phe His Ser Pro Gly Gly Ser Pro 
         675                680                685
Leu Lys Ser Ile Gln Ala Thr Leu Thr Pro Ser Ala Met Lys Ser Ser 
     690                695                700
Pro Gln Ile Pro His Lys Thr Tyr Ser Asn Ile Leu Lys His Leu Asn 
 705                710                715                720



<210> 3822
<211> 4193
<212> DNA
<213> Homo sapiens
<308> NM_002748
<400> 3822

catggcggc  actgcggca  agcgagagc  tcggagacg  cgctgccgc  agcacagcc  60
gagatctga  ccgacactg  gggcagtcc  cgagccccg  actctctcg  tgagtcgga  120
aagtcccgt  gtatcagag  aagatggac  gtagctttg  ttgtgattg  ggtgagctg  180
agccacctg  tcactaaca  aagacatct  ctgttaacc  acagccgcc  ggcttcctg  240
tgaaataaa  atatagcaa  aaaggaaaa  aagaagcaa  acggaaata  tgcttacca  300
caccttaga  tgatgctgc  caggaccag  ccaacactg  atgtatctg  actgtgagg  360
gaatgttca  agaagcctg  tgtgtgcat  tttattcac  ttttgttaa  tgttaaatc  420
tttagcacg  taatctgag  gcacagtat  tcatttcat  ccgtttgag  ttcttgttt  480
cgttaaatg  ctgcagagt  gctgcccct  tcttgaact  tgagtactg  aatcttttt  540
attctcaat  tgaatagag  tttttgagc  ttaaatcta  ggggaactc  acaggcctg  600
ttggcatat  caatgaaca  caagaaacc  tcttgctgt  gaagcataa  tatttttct  660
ctccctttt  gaaagatct  tccttttga  gccagtttt  ttccttgtt  acacaagtt  720
aatttgaaa  gaaaaggca  tagtaaggg  ttcaaaatg  cagagaaat  tgaaagtct  780
atgaacatt  atggttttg  tctgggttc  aggtatatg  acttaaaac  attgggttg  840
ggaggcaat  gcttggttt  ttctgctgt  gacaatgac  gtgacaaaa  agtagccat  900
aagaaaatt  tccttactg  tccccagag  gtcaaacat  ctctacgtg  aatcaaaat  960
attagaaga  ttgaccatg  taacattgt  aaagtgttt  agattcttg  tcccagtgg  1020
agccaatta  cagacgatg  gggctctct  acggaactg  acagtgttt  cattgttca  1080
gagtacatg  agacagact  ggctaatgt  ctggagcag  gccctttac  ggaagagca  1140
gccaggctt  tcatgtatc  gctgctacg  gggctcaag  atattcact  tgcaaatgt  1200
ctgcacaga  atctcaaac  agctaatct  ttcattaat  cggaagact  ggtgctgaa  1260
ataggtgac  ttggtcttg  acggatcat  gatcctcat  attcccata  gggtcatct  1320
tctgaagga  tggttacta  atggtacag  tctccacgt  ttttacttt  tcctaataa  1380
tatactaaa  ccattgaca  gtgggctgc  ggctgcatc  ttgctgaaa  gctgactgg  1440
aaaaccctt  ttgcaggtg  acatgaact  gaacagatg  agctgattt  agaatctat  1500
cctgttgta  atgaggaag  tcgtcagga  cttctcagc  taattccag  ttacattag  1560
aatgacatg  ctgagccac  caaaccttt  actcagctg  ttccaggaa  tagtcgaga  1620
gcactggat  tcctggaac  aattttgac  tttagcccc  tggatcggt  aacagcaga  1680
gaagcactc  cccatcctt  catgagcat  tattctttt  caatggatg  gccaatttc  1740
agccatcct  ttcatattg  agatgaagt  gatgatatt  tgcttatgg  tgaaactca  1800
agtcacatt  ataactggg  aaggtatca  gattgtcag  tttcagagc  tgattggcc  1860
gtacataac  actttgata  tgatgaagt  cagcttgat  caagagctc  gtccgatgt  1920
actgatgaa  aagaagtac  agttgatcc  cgaaaatat  tggatggag  tcgggaaaa  1980
tatctggag  atcctgctt  tgataccaa  tactctact  agccttgtt  gcaatactc  2040
gatcatcat  aaaacaaat  ttgtgatct  gagtgtagc  atacttgta  ctacaaaac  2100
aggtcatca  catatttag  taacttagt  tggagagag  gtgaagtta  ccattacta  2160
gaacccaag  ttattatag  tctttccaa  tggaaagaa  aaagcaaag  aaaatctga  2220
aagaaaggc  aatcaaaat  tgaaaggaa  ggattggtt  aagcccaga  agcgctaga  2280
gaagcatca  agcaactgg  tggaaaaga  agggaaaag  atcagggat  tgattttga  2340
tcctttatt  caggaacta  tcagcttag  tcccagcat  agcctactg  tgttgttga  2400
aaattaaat  acttgaata  ctcagtgtc  caactagaa  tgaaaagtt  gatatcaaa  2460
tcagtaagc  aagaaaaac  ggaaaaagg  atggcaaat  tggctcaat  agaagcctt  2520
taccagtct  cttgggaca  ccagtttgt  agtggtggg  aggactgtt  tttcataaa  2580
cagttttgt  aggtaagga  ggatgaaca  gttgagaag  aaaacactt  cactagtta  2640
ttggacaag  tctttagca  gaaagaaga  actgaaatg  tagaaactg  gccagtaga  2700
gatgggaag  ttggggaga  aggacatga  gaaggattt  tgaacaaca  tggggagtt  2760
ctctttaac  agcagctcg  gtccatagg  atcccacag  ttcacagtc  agttgggtc  2820
ccacttaag  caatacagg  cacattaac  ccttctgct  tgaaatctt  ccctcaaat  2880
cctcatcaa  catacagca  cattctgaa  catctgaac  aaaacactc  gcagacatt  2940
atctttgta  tcttcatga  atgtgtttt  tcttttttt  ttactagtg  ttaagtcat  3000
ttttacttg  atcagatgg  gtcatttag  aaggatttt  tgagttctt  ttttttaaa  3060
tccagactt  ctttttcta  atgtgagat  gttttcatt  taactggca  gtcatttgc  3120
cacaaaaat  aagactaga  caaaataat  caacgcagg  ggagaaaag  aatgcacta  3180
gacaagaac  ttctctcat  gaacattga  ctgttttac  ggaaacaaa  cttgccttg  3240
aatttacac  gtgagactg  acataattg  atgaaaata  ctatttttt  cctaagaca  3300
ttttcattc  tgaatattt  caagttttt  atactgtac  catttctta  aacacatga  3360
accagcagc  actgaaaat  aatgccgaa  ttggtacac  tgtgttatc  acctcaagg  3420
aacaagagt  tgtggcaaa  catatacca  ccatagtgc  tcacaaaat  cacttctat  3480
tagccagcg  ttattgtag  aaactattc  taataaaac  cactcactg  ttataaatg  3540
tctggtatg  attctttat  gtgaagtgt  aatacatca  atcttattt  ttttagcaa  3600
tcagtatat  ttctgtatt  aattataaa  aattaactt  gtttttaaa  tttatttgc  3660
aatatactt  ttccatttg  cactatggt  tgttgccta  ctagctgca  ctataatgt  3720
agcttatcc  aaggctgtc  acgtactta  tttacttaa  tgttcattt  aagtaacgt  3780
ctcactgtg  ataggaatt  gtattttgg  ggtgcttga  ctatctaca  agaaaaatt  3840
attaggaat  actttatta  aaaatgctc  tagaagtct  aattgtgtt  attttttaa  3900
aaaacaaat  ttagacttg  gtgcatgga  gtaattaag  tacatcatt  ttgtagttt  3960
aaagttgta  atgataaga  attttgttt  tactgtatg  ttttactga  tgatctatt  4020
cccatccca  ggcaagcat  aataaaatt  ggttaaacg  agcatgtgg  atcgcagtc  4080
cttagaatt  gtttcatct  ttttatttt  ttgaatact  tctgtatct  tggttatcc  4140
gtttgaaga  aaaggacaa  taaaacatg  ccagcaaat  caaaaaaaa  aaa  4193



<210> 3823
<211> 721
<212> PRT
<213> Homo sapiens
<308> Q16659
<400> 3823

Met Ala Glu Lys Phe Glu Ser Leu Met Asn Ile His Gly Phe Asp Leu 
  1               5                  10                  15
Gly Ser Arg Tyr Met Asp Leu Lys Pro Leu Gly Cys Gly Gly Asn Gly 
             20                  25                  30
Leu Val Phe Ser Ala Val Asp Asn Asp Cys Asp Lys Arg Val Ala Ile 
         35                  40                  45
Lys Lys Ile Val Leu Thr Asp Pro Gln Ser Val Lys His Ala Leu Arg 
     50                  55                  60
Glu Ile Lys Ile Ile Arg Arg Leu Asp His Asp Asn Ile Val Lys Val 
 65                  70                  75                  80
Phe Glu Ile Leu Gly Pro Ser Gly Ser Gln Leu Thr Asp Asp Val Gly 
                 85                  90                  95
Ser Leu Thr Glu Leu Asn Ser Val Tyr Ile Val Gln Glu Tyr Met Glu 
             100                105                110
Thr Asp Leu Ala Asn Val Leu Glu Gln Gly Pro Leu Leu Glu Glu His 
         115                120                125
Ala Arg Leu Phe Met Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Ile His 
     130                135                140
Ser Ala Asn Val Leu His Arg Asp Leu Lys Pro Ala Asn Leu Phe Ile 
 145                150                155                160
Asn Thr Glu Asp Leu Val Leu Lys Ile Gly Asp Phe Gly Leu Ala Arg 
                 165                170                175
Ile Met Asp Pro His Tyr Ser His Lys Gly His Leu Ser Glu Gly Leu 
             180                185                190
Val Thr Lys Trp Tyr Arg Ser Pro Arg Leu Leu Leu Ser Pro Asn Asn 
         195                200                205
Tyr Thr Lys Ala Ile Asp Met Trp Ala Ala Gly Cys Ile Phe Ala Glu 
     210                215                220
Met Leu Thr Gly Lys Thr Leu Phe Ala Gly Ala His Glu Leu Glu Gln 
 225                230                235                240
Met Gln Leu Ile Leu Glu Ser Ile Pro Val Val His Glu Glu Asp Arg 
                 245                250                255
Gln Glu Leu Leu Ser Val Ile Pro Val Tyr Ile Arg Asn Asp Met Thr 
             260                265                270
Glu Pro His Lys Pro Leu Thr Gln Leu Leu Pro Gly Ile Ser Arg Glu 
         275                280                285
Ala Leu Asp Phe Leu Glu Gln Ile Leu Thr Phe Ser Pro Met Asp Arg 
     290                295                300
Leu Thr Ala Glu Glu Ala Leu Ser His Pro Tyr Met Ser Ile Tyr Ser 
 305                310                315                320
Phe Pro Met Asp Glu Pro Ile Ser Ser His Pro Phe His Ile Glu Asp 
                 325                330                335
Glu Val Asp Asp Ile Leu Leu Met Asp Glu Thr His Ser His Ile Tyr 
             340                345                350
Asn Trp Glu Arg Tyr His Asp Cys Gln Phe Ser Glu His Asp Trp Pro 
         355                360                365
Val His Asn Asn Phe Asp Ile Asp Glu Val Gln Leu Asp Pro Arg Ala 
     370                375                380
Leu Ser Asp Val Thr Asp Glu Glu Glu Val Gln Val Asp Pro Arg Lys 
 385                390                395                400
Tyr Leu Asp Gly Asp Arg Glu Lys Tyr Leu Glu Asp Pro Ala Phe Asp 
                 405                410                415
Thr Asn Tyr Ser Thr Glu Pro Cys Trp Gln Tyr Ser Asp His His Glu 
             420                425                430
Asn Lys Tyr Cys Asp Leu Glu Cys Ser His Thr Cys Asn Tyr Lys Thr 
         435                440                445
Arg Ser Ser Ser Tyr Leu Asp Asn Leu Val Trp Arg Glu Ser Glu Val 
     450                455                460
Asn His Tyr Tyr Glu Pro Lys Leu Ile Ile Asp Leu Ser Asn Trp Lys 
 465                470                475                480
Glu Gln Ser Lys Glu Lys Ser Asp Lys Lys Gly Lys Ser Lys Cys Glu 
                 485                490                495
Arg Asn Gly Leu Val Lys Ala Gln Ile Ala Leu Glu Glu Ala Ser Gln 
             500                505                510
Gln Leu Ala Gly Lys Glu Arg Glu Lys Asn Gln Gly Phe Asp Phe Asp 
         515                520                525
Ser Phe Ile Ala Gly Thr Ile Gln Leu Ser Ser Gln His Glu Pro Thr 
     530                535                540
Asp Val Val Asp Lys Leu Asn Asp Leu Asn Ser Ser Val Ser Gln Leu 
 545                550                555                560
Glu Leu Lys Ser Leu Ile Ser Lys Ser Val Ser Gln Glu Lys Gln Glu 
                 565                570                575
Lys Gly Met Ala Asn Leu Ala Gln Leu Glu Ala Leu Tyr Gln Ser Ser 
             580                585                590
Trp Asp Ser Gln Phe Val Ser Gly Gly Glu Asp Cys Phe Phe Ile Asn 
         595                600                605
Gln Phe Cys Glu Val Arg Lys Asp Glu Gln Val Glu Lys Glu Asn Thr 
     610                615                620
Tyr Thr Ser Tyr Leu Asp Lys Phe Phe Ser Arg Lys Glu Asp Thr Glu 
 625                630                635                640
Met Leu Glu Thr Glu Pro Val Glu Asp Gly Lys Leu Gly Glu Arg Gly 
                 645                650                655
His Glu Glu Gly Phe Leu Asn Asn Ser Gly Glu Phe Leu Phe Asn Lys 
             660                665                670
Gln Leu Glu Ser Ile Gly Ile Pro Gln Phe His Ser Pro Val Gly Ser 
         675                680                685
Pro Leu Lys Ser Ile Gln Ala Thr Leu Thr Pro Ser Ala Met Lys Ser 
     690                695                700
Ser Pro Gln Ile Pro His Gln Thr Tyr Ser Ser Ile Leu Lys His Leu 
 705                710                715                720
Asn 
                 725



<210> 3824
<211> 3662
<212> DNA
<213> Rattus norvegicus
<308> M64301
<400> 3824

agacctgcc  ggcgcatat  tattcacag  tttgtccca  gttaagtcg  ttagcatag  60
gaatctgag  gcatagtat  tcatttcat  ccgttgagt  tctcgagtg  tttctttaa  120
tgtctgcag  gtcgctacc  ttccttgaa  tatgaagca  tgcaatctt  ttaattctc  180
gtatgaaga  agatttttg  gctttaagt  tgaggggaa  tcagcaggc  tggttggcg  240
ctgcaatga  catcaagaa  ccatcgtgc  gtgggaatg  gatcgtttt  ctccctttt  300
gagagatct  tccttttga  gccagtttt  ttccttgtt  acacaagtt  aacaatttg  360
aaggaaaag  caattgtaa  ggttttaaa  tggcagaga  atttgaaag  ctcatgaac  420
ttcatggct  tgatctggg  tccaggtac  tggacttaa  accattggg  tgtggaggc  480
atggcttgg  tttttctgc  gtagacaat  actgtgaca  aagagtagc  atcaagaaa  540
ttgtcctca  cgatcccca  agtgtcaaa  atgccctcc  tgaaatcaa  attattaga  600
gacttgacc  cgataacat  gtgaaagtg  ttgaaattc  tggtcccag  ggaagccag  660
tgacagacg  tgtgggctc  ctaacagag  tgaatagcg  ctacattgt  caggagtac  720
tggagacag  cttggcgaa  gtgctggag  agggccctt  actggagga  catgccagg  780
tcttcatgt  ccagctgct  cgtgggctc  agtacatcc  ctctgcaaa  gtgctgcac  840
gggatctca  gccggccaa  cttttcatt  acactgaag  cttggtgct  aagattggt  900
actttggcc  ggcccggat  atggatcct  attattccc  taagggtca  ctttctgaa  960
gattggtta  caaatggta  agatctcca  ggcttttac  ttctcctaa  aactatact  1020
aagccattg  catgtgggc  gcaggctgc  tctttgctg  aatgctgac  ggtaaaacc  1080
tctttgcag  tgcacatga  cttgaacag  tgcagctga  cttggagtc  atccctgtt  1140
tgcacgagg  agatcggca  gagcttctc  gcgtgattc  agtttacat  agaaacgac  1200
tgactgagc  acacaaacc  ctgactcag  tgcttccgg  gattagtcg  gaagcactg  1260
atttcctgg  acagattct  acgttcagt  ccatggacc  gctgacagc  gaggaagca  1320
tttcccatc  ttacatgag  atctactct  tcccaacgg  cgagcctat  tccagccat  1380
ctttccaca  agaagacga  gtggacgac  ttttgctaa  ggatgaaac  cacagtcac  1440
tttataact  ggaaaggta  cacgattgt  agttctcgg  gcatgactg  cctattcat  1500
acaactttg  tatcgatga  gttcagctt  acccgagag  tctgtctga  gtcaccgat  1560
aagaagaag  tcaagttga  cctcgaaag  acttggatg  agaccgaga  aagtatctg  1620
aggatcccg  cttcgacac  agctactct  ctgagcctt  ctggcagta  ccagatcac  1680
acgagaaca  gtactgtga  ctggagtgt  gccacacct  taactacaa  acaaggtcg  1740
catcatact  agataacct  gtgtggagg  agagcgagg  taaccatta  tatgagccc  1800
agcttatta  agatctttc  aactggaaa  agcaaagta  ggacaaatc  gacaagaga  1860
gcaagtcca  gtgtgagag  aacgggttg  tcaagcgca  attgcgctt  aggaagcgt  1920
ccagcagct  gctgagagg  agaggggcc  aggctttga  tttgatgcc  tcatcgcag  1980
caccgttca  ctcagtgcc  agcgtgagt  tgctgacgt  gttgacaag  taaacgact  2040
gaatagctc  gtgtcccag  tagaaatga  aagcctgat  tccaagtca  tcagccgag  2100
aaagcaaga  aagggaagg  ctaacctgg  ccagctggg  gccttgtac  agccctcct  2160
ggagagcca  tttgtgagt  gcggggagg  gtgcttcct  atcagtcag  tttgttgtg  2220
ggtcaggaa  gacgaacac  tggagaagg  gaacactta  accagctat  tggacaagt  2280
ttttagcag  aaggaggat  ctgaaatgc  agaaactga  ccagtggaa  aagggaagc  2340
tggggagag  ggccgtgag  cagggcttc  gagcagcgg  ggggagttt  tcctgagca  2400
gcagctaga  tccataggc  ccccgcagt  ccacagtcc  gggggatcc  cactcaagt  2460
catccaggc  acgttaaca  cttccgcta  gaaatcttc  cctcaaatc  ctcacaaga  2520
atacagcaa  attctgaaa  atctgaact  aacactcag  agacacttc  tttgttctt  2580
atgaaatgt  ttgtgtctt  tttatcact  atgttttaa  tcatttttt  tttacttga  2640
tcagaaggt  tcattaatt  gcaaggatt  ttcttggtt  tcagtttgt  aaacacaga  2700
ttttttcta  atgtgagtt  gttttcatt  gaactggca  gtcgtttgc  cacacacaa  2760
gaatagagc  aaacaatgc  gtgcaggag  agacaagat  cgctaggat  gacagacat  2820
ctcacagac  agtgacctg  ttacaggaa  caaaacctt  ccttgaaac  tacacagtg  2880
gactgtaca  aattgcatg  aaagatcta  ttttttcct  aaacatttt  cattcatta  2940
tattttcaa  tttttcata  tgtacacat  tcttaagac  catgatacc  gcagcaact  3000
aaaacgaat  ccgaatttg  tacacatgt  ttatctacc  caaggtaac  aaagtatgc  3060
ggcgaaacc  aacccaccc  tagtcgtcc  cggcatatg  acttgtatc  agccagcgt  3120
ggccgcagt  accaatgag  ctcgtccgc  atttatcaa  gtcctggtg  tcatccttt  3180
cagtgaagt  ttagataca  cacatctta  ttattttta  caaatcagt  tattttctg  3240
atttaatta  aaaaggtaa  ttagtttaa  tttatttgc  actgccctt  ttcccgttt  3300
gcactatgg  ttgttgcct  ccgagctga  ctgagaagt  agcttgtcc  gaggctgtc  3360
atgtacgtt  agtaaagtg  tcactgtgt  taggaatct  tattttgga  gtgcttgat  3420
tatctacaa  gaaaaaaat  aggaattta  tataaaatg  tcctagaag  cttaatggt  3480
tttattttt  aaaaccttg  aatgttaga  ttgtgtgca  ggaagtgat  aaggtacat  3540
attattgta  tttgaacat  gtacatgat  agccttccc  cacccccgt  tttactgta  3600
gtttttatt  aatgatcta  tccccatcc  taggcaagc  tgaataaaa  taggttaaa  3660
gt  3662



<210> 3825
<211> 720
<212> PRT
<213> Rattus norvegicus
<308> P27704
<400> 3825

Met Ala Glu Lys Phe Glu Ser Leu Met Asn Ile His Gly Phe Asp Leu 
  1               5                  10                  15
Gly Ser Arg Tyr Met Asp Leu Lys Pro Leu Gly Cys Gly Gly Asn Gly 
             20                  25                  30
Leu Val Phe Ser Ala Val Asp Asn Asp Cys Asp Lys Arg Val Ala Ile 
         35                  40                  45
Lys Lys Ile Val Leu Thr Asp Pro Gln Ser Val Lys His Ala Leu Arg 
     50                  55                  60
Glu Ile Lys Ile Ile Arg Arg Leu Asp His Asp Asn Ile Val Lys Val 
 65                  70                  75                  80
Phe Glu Ile Leu Gly Pro Ser Gly Ser Gln Leu Thr Asp Asp Val Gly 
                 85                  90                  95
Ser Leu Thr Glu Leu Asn Ser Val Tyr Ile Val Gln Glu Tyr Met Glu 
             100                105                110
Thr Asp Leu Ala Asn Val Leu Glu Gln Gly Pro Leu Leu Glu Glu His 
         115                120                125
Ala Arg Leu Phe Met Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Ile His 
     130                135                140
Ser Ala Asn Val Leu His Arg Asp Leu Lys Pro Ala Asn Leu Phe Ile 
 145                150                155                160
Asn Thr Glu Asp Leu Val Leu Lys Ile Gly Asp Phe Gly Leu Ala Arg 
                 165                170                175
Ile Met Asp Pro His Tyr Ser His Lys Gly His Leu Ser Glu Gly Leu 
             180                185                190
Val Thr Lys Trp Tyr Arg Ser Pro Arg Leu Leu Leu Ser Pro Asn Asn 
         195                200                205
Tyr Thr Lys Ala Ile Asp Met Trp Ala Ala Gly Cys Ile Phe Ala Glu 
     210                215                220
Met Leu Thr Gly Lys Thr Leu Phe Ala Gly Ala His Glu Leu Glu Gln 
 225                230                235                240
Met Gln Leu Ile Leu Glu Ser Ile Pro Val Val His Glu Glu Asp Arg 
                 245                250                255
Gln Glu Leu Leu Ser Val Ile Pro Val Tyr Ile Arg Asn Asp Met Thr 
             260                265                270
Glu Pro His Lys Pro Leu Thr Gln Leu Leu Pro Gly Ile Ser Arg Glu 
         275                280                285
Ala Leu Asp Phe Leu Glu Gln Ile Leu Thr Phe Ser Pro Met Asp Arg 
     290                295                300
Leu Thr Ala Glu Glu Ala Leu Ser His Pro Tyr Met Ser Ile Tyr Ser 
 305                310                315                320
Phe Pro Thr Asp Glu Pro Ile Ser Ser His Pro Phe His Ile Glu Asp 
                 325                330                335
Glu Val Asp Asp Ile Leu Leu Met Asp Glu Thr His Ser His Ile Tyr 
             340                345                350
Asn Trp Glu Arg Tyr His Asp Cys Gln Phe Ser Glu His Asp Trp Pro 
         355                360                365
Ile His Asn Asn Phe Asp Ile Asp Glu Val Gln Leu Asp Pro Arg Ala 
     370                375                380
Leu Ser Asp Val Thr Asp Glu Glu Glu Val Gln Val Asp Pro Arg Lys 
 385                390                395                400
Tyr Leu Asp Gly Asp Arg Glu Lys Tyr Leu Glu Asp Pro Ala Phe Asp 
                 405                410                415
Thr Ser Tyr Ser Ala Glu Pro Cys Trp Gln Tyr Pro Asp His His Glu 
             420                425                430
Asn Lys Tyr Cys Asp Leu Glu Cys Ser His Thr Cys Asn Tyr Lys Thr 
         435                440                445
Arg Ser Pro Ser Tyr Leu Asp Asn Leu Val Trp Arg Glu Ser Glu Val 
     450                455                460
Asn His Tyr Tyr Glu Pro Lys Leu Ile Ile Asp Leu Ser Asn Trp Lys 
 465                470                475                480
Glu Gln Ser Lys Asp Lys Ser Asp Lys Arg Gly Lys Ser Lys Cys Glu 
                 485                490                495
Arg Asn Gly Leu Val Lys Ala Gln Ile Ala Leu Glu Glu Ala Ser Gln 
             500                505                510
Gln Leu Ala Glu Arg Glu Arg Gly Gln Gly Phe Asp Phe Asp Ala Phe 
         515                520                525
Ile Ala Gly Thr Val Gln Leu Ser Ala Gln Arg Glu Ser Ala Asp Val 
     530                535                540
Val Asp Lys Leu Asn Asp Leu Asn Ser Ser Val Ser Gln Leu Glu Met 
 545                550                555                560
Lys Ser Leu Ile Ser Lys Ser Val Ser Arg Glu Lys Gln Glu Lys Gly 
                 565                570                575
Arg Ala Asn Leu Ala Gln Leu Gly Ala Leu Tyr Gln Pro Ser Trp Glu 
             580                585                590
Ser Gln Phe Val Ser Gly Gly Glu Glu Cys Phe Leu Ile Ser Gln Phe 
         595                600                605
Cys Cys Glu Val Arg Lys Asp Glu His Val Glu Lys Glu Asn Thr Tyr 
     610                615                620
Thr Ser Tyr Leu Asp Lys Phe Phe Ser Arg Lys Glu Asp Ser Glu Met 
 625                630                635                640
Leu Glu Thr Glu Pro Val Glu Glu Gly Lys Arg Gly Glu Arg Gly Arg 
                 645                650                655
Glu Ala Gly Leu Leu Ser Ser Gly Gly Glu Phe Leu Leu Ser Arg Gln 
             660                665                670
Leu Glu Ser Ile Gly Thr Pro Gln Phe His Ser Pro Gly Gly Ser Pro 
         675                680                685
Leu Lys Ser Ile Gln Ala Thr Leu Thr Pro Ser Ala Met Lys Ser Ser 
     690                695                700
Pro Gln Ile Pro His Lys Thr Tyr Ser Asn Ile Leu Lys His Leu Asn 
 705                710                715                720



<210> 3826
<211> 4193
<212> DNA
<213> Homo sapiens
<308> NM_002748
<400> 3826

catggcggc  actgcggca  agcgagagc  tcggagacg  cgctgccgc  agcacagcc  60
gagatctga  ccgacactg  gggcagtcc  cgagccccg  actctctcg  tgagtcgga  120
aagtcccgt  gtatcagag  aagatggac  gtagctttg  ttgtgattg  ggtgagctg  180
agccacctg  tcactaaca  aagacatct  ctgttaacc  acagccgcc  ggcttcctg  240
tgaaataaa  atatagcaa  aaaggaaaa  aagaagcaa  acggaaata  tgcttacca  300
caccttaga  tgatgctgc  caggaccag  ccaacactg  atgtatctg  actgtgagg  360
gaatgttca  agaagcctg  tgtgtgcat  tttattcac  ttttgttaa  tgttaaatc  420
tttagcacg  taatctgag  gcacagtat  tcatttcat  ccgtttgag  ttcttgttt  480
cgttaaatg  ctgcagagt  gctgcccct  tcttgaact  tgagtactg  aatcttttt  540
attctcaat  tgaatagag  tttttgagc  ttaaatcta  ggggaactc  acaggcctg  600
ttggcatat  caatgaaca  caagaaacc  tcttgctgt  gaagcataa  tatttttct  660
ctccctttt  gaaagatct  tccttttga  gccagtttt  ttccttgtt  acacaagtt  720
aatttgaaa  gaaaaggca  tagtaaggg  ttcaaaatg  cagagaaat  tgaaagtct  780
atgaacatt  atggttttg  tctgggttc  aggtatatg  acttaaaac  attgggttg  840
ggaggcaat  gcttggttt  ttctgctgt  gacaatgac  gtgacaaaa  agtagccat  900
aagaaaatt  tccttactg  tccccagag  gtcaaacat  ctctacgtg  aatcaaaat  960
attagaaga  ttgaccatg  taacattgt  aaagtgttt  agattcttg  tcccagtgg  1020
agccaatta  cagacgatg  gggctctct  acggaactg  acagtgttt  cattgttca  1080
gagtacatg  agacagact  ggctaatgt  ctggagcag  gccctttac  ggaagagca  1140
gccaggctt  tcatgtatc  gctgctacg  gggctcaag  atattcact  tgcaaatgt  1200
ctgcacaga  atctcaaac  agctaatct  ttcattaat  cggaagact  ggtgctgaa  1260
ataggtgac  ttggtcttg  acggatcat  gatcctcat  attcccata  gggtcatct  1320
tctgaagga  tggttacta  atggtacag  tctccacgt  ttttacttt  tcctaataa  1380
tatactaaa  ccattgaca  gtgggctgc  ggctgcatc  ttgctgaaa  gctgactgg  1440
aaaaccctt  ttgcaggtg  acatgaact  gaacagatg  agctgattt  agaatctat  1500
cctgttgta  atgaggaag  tcgtcagga  cttctcagc  taattccag  ttacattag  1560
aatgacatg  ctgagccac  caaaccttt  actcagctg  ttccaggaa  tagtcgaga  1620
gcactggat  tcctggaac  aattttgac  tttagcccc  tggatcggt  aacagcaga  1680
gaagcactc  cccatcctt  catgagcat  tattctttt  caatggatg  gccaatttc  1740
agccatcct  ttcatattg  agatgaagt  gatgatatt  tgcttatgg  tgaaactca  1800
agtcacatt  ataactggg  aaggtatca  gattgtcag  tttcagagc  tgattggcc  1860
gtacataac  actttgata  tgatgaagt  cagcttgat  caagagctc  gtccgatgt  1920
actgatgaa  aagaagtac  agttgatcc  cgaaaatat  tggatggag  tcgggaaaa  1980
tatctggag  atcctgctt  tgataccaa  tactctact  agccttgtt  gcaatactc  2040
gatcatcat  aaaacaaat  ttgtgatct  gagtgtagc  atacttgta  ctacaaaac  2100
aggtcatca  catatttag  taacttagt  tggagagag  gtgaagtta  ccattacta  2160
gaacccaag  ttattatag  tctttccaa  tggaaagaa  aaagcaaag  aaaatctga  2220
aagaaaggc  aatcaaaat  tgaaaggaa  ggattggtt  aagcccaga  agcgctaga  2280
gaagcatca  agcaactgg  tggaaaaga  agggaaaag  atcagggat  tgattttga  2340
tcctttatt  caggaacta  tcagcttag  tcccagcat  agcctactg  tgttgttga  2400
aaattaaat  acttgaata  ctcagtgtc  caactagaa  tgaaaagtt  gatatcaaa  2460
tcagtaagc  aagaaaaac  ggaaaaagg  atggcaaat  tggctcaat  agaagcctt  2520
taccagtct  cttgggaca  ccagtttgt  agtggtggg  aggactgtt  tttcataaa  2580
cagttttgt  aggtaagga  ggatgaaca  gttgagaag  aaaacactt  cactagtta  2640
ttggacaag  tctttagca  gaaagaaga  actgaaatg  tagaaactg  gccagtaga  2700
gatgggaag  ttggggaga  aggacatga  gaaggattt  tgaacaaca  tggggagtt  2760
ctctttaac  agcagctcg  gtccatagg  atcccacag  ttcacagtc  agttgggtc  2820
ccacttaag  caatacagg  cacattaac  ccttctgct  tgaaatctt  ccctcaaat  2880
cctcatcaa  catacagca  cattctgaa  catctgaac  aaaacactc  gcagacatt  2940
atctttgta  tcttcatga  atgtgtttt  tcttttttt  ttactagtg  ttaagtcat  3000
ttttacttg  atcagatgg  gtcatttag  aaggatttt  tgagttctt  ttttttaaa  3060
tccagactt  ctttttcta  atgtgagat  gttttcatt  taactggca  gtcatttgc  3120
cacaaaaat  aagactaga  caaaataat  caacgcagg  ggagaaaag  aatgcacta  3180
gacaagaac  ttctctcat  gaacattga  ctgttttac  ggaaacaaa  cttgccttg  3240
aatttacac  gtgagactg  acataattg  atgaaaata  ctatttttt  cctaagaca  3300
ttttcattc  tgaatattt  caagttttt  atactgtac  catttctta  aacacatga  3360
accagcagc  actgaaaat  aatgccgaa  ttggtacac  tgtgttatc  acctcaagg  3420
aacaagagt  tgtggcaaa  catatacca  ccatagtgc  tcacaaaat  cacttctat  3480
tagccagcg  ttattgtag  aaactattc  taataaaac  cactcactg  ttataaatg  3540
tctggtatg  attctttat  gtgaagtgt  aatacatca  atcttattt  ttttagcaa  3600
tcagtatat  ttctgtatt  aattataaa  aattaactt  gtttttaaa  tttatttgc  3660
aatatactt  ttccatttg  cactatggt  tgttgccta  ctagctgca  ctataatgt  3720
agcttatcc  aaggctgtc  acgtactta  tttacttaa  tgttcattt  aagtaacgt  3780
ctcactgtg  ataggaatt  gtattttgg  ggtgcttga  ctatctaca  agaaaaatt  3840
attaggaat  actttatta  aaaatgctc  tagaagtct  aattgtgtt  attttttaa  3900
aaaacaaat  ttagacttg  gtgcatgga  gtaattaag  tacatcatt  ttgtagttt  3960
aaagttgta  atgataaga  attttgttt  tactgtatg  ttttactga  tgatctatt  4020
cccatccca  ggcaagcat  aataaaatt  ggttaaacg  agcatgtgg  atcgcagtc  4080
cttagaatt  gtttcatct  ttttatttt  ttgaatact  tctgtatct  tggttatcc  4140
gtttgaaga  aaaggacaa  taaaacatg  ccagcaaat  caaaaaaaa  aaa  4193



<210> 3827
<211> 721
<212> PRT
<213> Homo sapiens
<308> Q16659
<400> 3827

Met Ala Glu Lys Phe Glu Ser Leu Met Asn Ile His Gly Phe Asp Leu 
  1               5                  10                  15
Gly Ser Arg Tyr Met Asp Leu Lys Pro Leu Gly Cys Gly Gly Asn Gly 
             20                  25                  30
Leu Val Phe Ser Ala Val Asp Asn Asp Cys Asp Lys Arg Val Ala Ile 
         35                  40                  45
Lys Lys Ile Val Leu Thr Asp Pro Gln Ser Val Lys His Ala Leu Arg 
     50                  55                  60
Glu Ile Lys Ile Ile Arg Arg Leu Asp His Asp Asn Ile Val Lys Val 
 65                  70                  75                  80
Phe Glu Ile Leu Gly Pro Ser Gly Ser Gln Leu Thr Asp Asp Val Gly 
                 85                  90                  95
Ser Leu Thr Glu Leu Asn Ser Val Tyr Ile Val Gln Glu Tyr Met Glu 
             100                105                110
Thr Asp Leu Ala Asn Val Leu Glu Gln Gly Pro Leu Leu Glu Glu His 
         115                120                125
Ala Arg Leu Phe Met Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Ile His 
     130                135                140
Ser Ala Asn Val Leu His Arg Asp Leu Lys Pro Ala Asn Leu Phe Ile 
 145                150                155                160
Asn Thr Glu Asp Leu Val Leu Lys Ile Gly Asp Phe Gly Leu Ala Arg 
                 165                170                175
Ile Met Asp Pro His Tyr Ser His Lys Gly His Leu Ser Glu Gly Leu 
             180                185                190
Val Thr Lys Trp Tyr Arg Ser Pro Arg Leu Leu Leu Ser Pro Asn Asn 
         195                200                205
Tyr Thr Lys Ala Ile Asp Met Trp Ala Ala Gly Cys Ile Phe Ala Glu 
     210                215                220
Met Leu Thr Gly Lys Thr Leu Phe Ala Gly Ala His Glu Leu Glu Gln 
 225                230                235                240
Met Gln Leu Ile Leu Glu Ser Ile Pro Val Val His Glu Glu Asp Arg 
                 245                250                255
Gln Glu Leu Leu Ser Val Ile Pro Val Tyr Ile Arg Asn Asp Met Thr 
             260                265                270
Glu Pro His Lys Pro Leu Thr Gln Leu Leu Pro Gly Ile Ser Arg Glu 
         275                280                285
Ala Leu Asp Phe Leu Glu Gln Ile Leu Thr Phe Ser Pro Met Asp Arg 
     290                295                300
Leu Thr Ala Glu Glu Ala Leu Ser His Pro Tyr Met Ser Ile Tyr Ser 
 305                310                315                320
Phe Pro Met Asp Glu Pro Ile Ser Ser His Pro Phe His Ile Glu Asp 
                 325                330                335
Glu Val Asp Asp Ile Leu Leu Met Asp Glu Thr His Ser His Ile Tyr 
             340                345                350
Asn Trp Glu Arg Tyr His Asp Cys Gln Phe Ser Glu His Asp Trp Pro 
         355                360                365
Val His Asn Asn Phe Asp Ile Asp Glu Val Gln Leu Asp Pro Arg Ala 
     370                375                380
Leu Ser Asp Val Thr Asp Glu Glu Glu Val Gln Val Asp Pro Arg Lys 
 385                390                395                400
Tyr Leu Asp Gly Asp Arg Glu Lys Tyr Leu Glu Asp Pro Ala Phe Asp 
                 405                410                415
Thr Asn Tyr Ser Thr Glu Pro Cys Trp Gln Tyr Ser Asp His His Glu 
             420                425                430
Asn Lys Tyr Cys Asp Leu Glu Cys Ser His Thr Cys Asn Tyr Lys Thr 
         435                440                445
Arg Ser Ser Ser Tyr Leu Asp Asn Leu Val Trp Arg Glu Ser Glu Val 
     450                455                460
Asn His Tyr Tyr Glu Pro Lys Leu Ile Ile Asp Leu Ser Asn Trp Lys 
 465                470                475                480
Glu Gln Ser Lys Glu Lys Ser Asp Lys Lys Gly Lys Ser Lys Cys Glu 
                 485                490                495
Arg Asn Gly Leu Val Lys Ala Gln Ile Ala Leu Glu Glu Ala Ser Gln 
             500                505                510
Gln Leu Ala Gly Lys Glu Arg Glu Lys Asn Gln Gly Phe Asp Phe Asp 
         515                520                525
Ser Phe Ile Ala Gly Thr Ile Gln Leu Ser Ser Gln His Glu Pro Thr 
     530                535                540
Asp Val Val Asp Lys Leu Asn Asp Leu Asn Ser Ser Val Ser Gln Leu 
 545                550                555                560
Glu Leu Lys Ser Leu Ile Ser Lys Ser Val Ser Gln Glu Lys Gln Glu 
                 565                570                575
Lys Gly Met Ala Asn Leu Ala Gln Leu Glu Ala Leu Tyr Gln Ser Ser 
             580                585                590
Trp Asp Ser Gln Phe Val Ser Gly Gly Glu Asp Cys Phe Phe Ile Asn 
         595                600                605
Gln Phe Cys Glu Val Arg Lys Asp Glu Gln Val Glu Lys Glu Asn Thr 
     610                615                620
Tyr Thr Ser Tyr Leu Asp Lys Phe Phe Ser Arg Lys Glu Asp Thr Glu 
 625                630                635                640
Met Leu Glu Thr Glu Pro Val Glu Asp Gly Lys Leu Gly Glu Arg Gly 
                 645                650                655
His Glu Glu Gly Phe Leu Asn Asn Ser Gly Glu Phe Leu Phe Asn Lys 
             660                665                670
Gln Leu Glu Ser Ile Gly Ile Pro Gln Phe His Ser Pro Val Gly Ser 
         675                680                685
Pro Leu Lys Ser Ile Gln Ala Thr Leu Thr Pro Ser Ala Met Lys Ser 
     690                695                700
Ser Pro Gln Ile Pro His Gln Thr Tyr Ser Ser Ile Leu Lys His Leu 
 705                710                715                720
Asn 
                 725



<210> 3828
<211> 1002
<212> DNA
<213> Rattus norvegicus
<308> M64376
<400> 3828

atggactca  gcaacagga  aagagtttc  gaatttctt  ttcttggat  tgtagaaaa  60
aaagaccta  aacccctta  ttatggtct  tttctctct  tgtacctgg  tactgtcat  120
ggaaacata  ccattattg  ggctatcat  tcagatccc  gtctgcaca  ccccatgta  180
ttcttcctc  ctaacctgt  ctttgtgga  atctgtttc  tttcaacca  tgttccaaa  240
atgttagtg  acatccaga  ccaaaacaa  gtcatcacc  atgcaggat  cattaccca  300
atatacttt  tcttgctct  tgtagaatt  gacaacttc  tgctgacta  catggccta  360
gaccgttac  tagccatct  tcaccccat  cactacaca  ttatcatga  ctacaagct  420
tgtggattt  tggttctgg  atcttggat  gtaagtgtt  tgcatgcct  gtttcaaag  480
ttgatgatg  tggcgctgc  cttctgcac  catctggaa  tcccacact  cttctgtga  540
cctaatcag  tgattcaac  cacctgttc  gatgcattt  ttaatgatc  tgtgatata  600
tttacactt  tgctgctgg  tactgttcc  cttgctggc  tcttctatt  ttacttcaa  660
atagtgtcc  ccatatgtg  tatatcgtc  gttcatggg  agtacaaag  attctccac  720
tgtgcatct  acctttcag  cgtgtcttt  ttttactgc  caggactag  agtgtacct  780
agttctgct  caaacaaca  ctcacaggc  agtgccaca  cctcagtca  gtacactgt  840
gttacccct  tggtgaacc  ttttatcta  agtcttagg  ataaagatg  taagagtgt  900
ctgaaaaaa  ctctttgtg  ggaagttat  aggagtcca  cttccctac  tcatttctt  960
ctagtgtta  gtcatctcc  ttgttttat  ttttgttat  aa  1002



<210> 3829
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> P23265
<400> 3829

Met Asp Ser Ser Asn Arg Thr Arg Val Ser Glu Phe Leu Leu Leu Gly 
  1               5                  10                  15
Phe Val Glu Asn Lys Asp Leu Gln Pro Leu Ile Tyr Gly Leu Phe Leu 
             20                  25                  30
Ser Met Tyr Leu Val Thr Val Ile Gly Asn Ile Ser Ile Ile Val Ala 
         35                  40                  45
Ile Ile Ser Asp Pro Cys Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
     50                  55                  60
Asn Leu Ser Phe Val Asp Ile Cys Phe Ile Ser Thr Thr Val Pro Lys 
 65                  70                  75                  80
Met Leu Val Asn Ile Gln Thr Gln Asn Asn Val Ile Thr Tyr Ala Gly 
                 85                  90                  95
Cys Ile Thr Gln Ile Tyr Phe Phe Leu Leu Phe Val Glu Leu Asp Asn 
             100                105                110
Phe Leu Leu Thr Ile Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 
         115                120                125
Pro Met His Tyr Thr Val Ile Met Asn Tyr Lys Leu Cys Gly Phe Leu 
     130                135                140
Val Leu Val Ser Trp Ile Val Ser Val Leu His Ala Leu Phe Gln Ser 
 145                150                155                160
Leu Met Met Leu Ala Leu Pro Phe Cys Thr His Leu Glu Ile Pro His 
                 165                170                175
Tyr Phe Cys Glu Pro Asn Gln Val Ile Gln Leu Thr Cys Ser Asp Ala 
             180                185                190
Phe Leu Asn Asp Leu Val Ile Tyr Phe Thr Leu Val Leu Leu Ala Thr 
         195                200                205
Val Pro Leu Ala Gly Ile Phe Tyr Ser Tyr Phe Lys Ile Val Ser Ser 
     210                215                220
Ile Cys Ala Ile Ser Ser Val His Gly Lys Tyr Lys Ala Phe Ser Thr 
 225                230                235                240
Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Gly Leu 
                 245                250                255
Gly Val Tyr Leu Ser Ser Ala Ala Asn Asn Ser Ser Gln Ala Ser Ala 
             260                265                270
Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Val Asn Pro Phe 
         275                280                285
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ser Val Leu Lys Lys Thr 
     290                295                300
Leu Cys Glu Glu Val Ile Arg Ser Pro Pro Ser Leu Leu His Phe Phe 
 305                310                315                320
Leu Val Leu Cys His Leu Pro Cys Phe Ile Phe Cys Tyr 
                 325                330



<210> 3831
<211> 2681
<212> DNA
<213> Rattus norvegicus
<308> M64488
<400> 3831

gggagccga  cggtgtggg  tggtggaga  ggcagcggg  gtctgccgc  ccgaagtcc  60
ggtcccctc  tcccactcc  gcgccggcc  gcgctgcgg  tcccctctg  caccatgag  120
aacatcttc  agaggaacc  ggagcccat  gtggctccg  ccaccacca  tgccacaat  180
cctctggca  ccgccgcac  tgccgataa  tctacagag  gcacgggca  cggggagag  240
caagaagac  tgttcgcca  gctgaagga  aaattcttc  atgagatca  caagatccc  300
ttgcccccc  gggctctga  tgccatggc  gtggttgct  gcctcctgc  gctcacctg  360
tgcttctgc  tctgtaaga  gtgctgctg  aagaagaag  aaaacaaga  ggagaaggg  420
aaaggcatg  agaacgcca  gaacatgaa  gacatgaag  ggggccagg  tgatgacga  480
gcggagaca  gcctgactg  aggagaagg  gaaggcgag  aggagaaag  gccggagaa  540
ctgggcaaa  tgcagtttt  tctggacta  gatttccaa  ccaaccagc  caccgtggg  600
gtcctgcag  ctgctgaac  cccggccct  gacatgggt  gcacgtcag  cccttacgt  660
aaagtcttc  tcctcccag  caagaagaa  aaatatgag  ccaaggtgc  ccggaagac  720
ctgaaccca  ccttcaacg  aactttcac  ttcaaggtg  cataccagg  gttaggagg  780
aaaaccctg  tgatggcta  ctatgactt  gaccgcttc  ctaagcatg  catcatcgg  840
gaggtgaaa  tgcccatga  cacggtgga  cttggccag  ccatcgagg  atggagaga  900
ctacaaggc  gagagaagg  agagccaga  aagctgggt  acatctgta  ctccttgcg  960
tacgtgccc  ctgctggga  gctcaccgt  tgtatcctg  aggccaaga  cctgaagaa  1020
atggatgtg  ggggcctct  agaccccta  gtgaagatc  acttgatgc  gaatggcaa  1080
agactcaag  agaagaaga  gacggtgaa  aagaagacc  tgaacccct  cttcaatga  1140
tcattcagc  tcgagatcc  ctttgagca  atccagaaa  tccaggtgg  cgtcaccgt  1200
ctagactat  acaaactgg  caagaatga  gccatcgga  agatcttcg  aggcagcaa  1260
gctacaggc  cggagctgc  gcactggtc  gacatgctg  cgaaccctc  gaggcccat  1320
gcccagtgg  actctctga  gcctgagga  gaagtggat  ctcttctgg  caagaacaa  1380
taggcagcg  cgcctgggg  cacgcccca  aggacactg  cgagctcca  agctatcaa  1440
acctcagtt  tgcgacctt  gaggtttct  catttgttt  cggtgtgtc  tgttttcct  1500
tcctttttc  ttttttgtc  ttttaaaaa  caacttcct  ttggtggct  tgtgaagag  1560
cccctaaga  gtgaaagag  agcctggct  tgttattgt  ccaggagct  tccttgttg  1620
atgccctat  acggttgcc  ctcacccca  gtggggccc  ctactgtca  agtggaagc  1680
cttcctgct  ttcctgggt  ttggaccaa  aaagtggca  gcacattct  tgtctcgac  1740
gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  gtacacgtg  1800
gcccatcca  ccccacctt  cctctgttt  gaatatctc  tcgtttctg  aatgagtca  1860
ggacaatga  gccgtgtga  agaggaaag  cttcaggta  tccgaggtg  ggagagccc  1920
ctgcttaag  ggtcagagg  cagaagctc  catagtcct  gcgaaaggc  atttggaag  1980
cgcaagatg  gatactgga  gtattccga  ctaggacca  aggcttgat  ccatcccag  2040
ctccctctt  tcagtcatg  cttccccag  agtggggct  tgggatcat  catgaaaat  2100
aactattta  tcgactggt  ggattcagc  agggaccgc  agctccagg  tgtcattct  2160
gttgacgac  tcaaacttt  aagaaacag  agtcccatt  ctcagctct  gatctttgc  2220
tcgtccagt  ggaggcaga  gcttcctcc  tctgcagag  acaagcagt  cgttcattt  2280
cattcacgc  ccatctgct  ttgcctctg  ttccctttt  gtgtaagtg  aaaaatacc  2340
tctgacgat  agtgctttg  acagagcca  agacctatt  gagggatgc  tgggtgttt  2400
gttcccttg  ggtccaggt  aggaggagg  gtcaagaag  ggagcgttg  tggacagtg  2460
caagctaga  attgcagag  tcctcacaa  tcctattcc  gaccctctg  accctttga  2520
cctcagtga  ggtagccgg  gtagcccag  cagacctta  gagaggccc  gtccttccc  2580
tccttagac  gttttctca  aatgccagg  aacacagcg  attcatttc  gatgggtgg  2640
ggagaaaat  tgctaaggt  tgcacccta  gttcggaat  c  2681



<210> 3832
<211> 422
<212> PRT
<213> Rattus norvegicus
<308> P29101
<400> 3832

Met Arg Asn Ile Phe Lys Arg Asn Gln Glu Pro Ile Val Ala Pro Ala 
  1               5                  10                  15
Thr Thr Thr Ala Thr Met Pro Leu Ala Pro Ala Ala Pro Ala Asp Asn 
             20                  25                  30
Ser Thr Glu Ser Thr Gly Thr Gly Glu Ser Gln Glu Asp Met Phe Ala 
         35                  40                  45
Lys Leu Lys Asp Lys Phe Phe Asn Glu Ile Asn Lys Ile Pro Leu Pro 
     50                  55                  60
Pro Trp Ala Leu Ile Ala Met Ala Val Val Ala Gly Leu Leu Leu Leu 
 65                  70                  75                  80
Thr Cys Cys Phe Cys Ile Cys Lys Lys Cys Cys Cys Lys Lys Lys Lys 
                 85                  90                  95
Asn Lys Lys Glu Lys Gly Lys Gly Met Lys Asn Ala Met Asn Met Lys 
             100                105                110
Asp Met Lys Gly Gly Gln Asp Asp Asp Asp Ala Glu Thr Gly Leu Thr 
         115                120                125
Glu Gly Glu Gly Glu Gly Glu Glu Glu Lys Glu Pro Glu Asn Leu Gly 
     130                135                140
Lys Leu Gln Phe Ser Leu Asp Tyr Asp Phe Gln Ala Asn Gln Leu Thr 
 145                150                155                160
Val Gly Val Leu Gln Ala Ala Glu Leu Pro Ala Leu Asp Met Gly Gly 
                 165                170                175
Thr Ser Asp Pro Tyr Val Lys Val Phe Leu Leu Pro Asp Lys Lys Lys 
             180                185                190
Lys Tyr Glu Thr Lys Val His Arg Lys Thr Leu Asn Pro Ala Phe Asn 
         195                200                205
Glu Thr Phe Thr Phe Lys Val Pro Tyr Gln Glu Leu Gly Gly Lys Thr 
     210                215                220
Leu Val Met Ala Ile Tyr Asp Phe Asp Arg Phe Ser Lys His Asp Ile 
 225                230                235                240
Ile Gly Glu Val Lys Val Pro Met Asn Thr Val Asp Leu Gly Gln Pro 
                 245                250                255
Ile Glu Glu Trp Arg Asp Leu Gln Gly Gly Glu Lys Glu Glu Pro Glu 
             260                265                270
Lys Leu Gly Asp Ile Cys Thr Ser Leu Arg Tyr Val Pro Thr Ala Gly 
         275                280                285
Lys Leu Thr Val Cys Ile Leu Glu Ala Lys Asn Leu Lys Lys Met Asp 
     290                295                300
Val Gly Gly Leu Ser Asp Pro Tyr Val Lys Ile His Leu Met Gln Asn 
 305                310                315                320
Gly Lys Arg Leu Lys Lys Lys Lys Thr Thr Val Lys Lys Lys Thr Leu 
                 325                330                335
Asn Pro Tyr Phe Asn Glu Ser Phe Ser Phe Glu Ile Pro Phe Glu Gln 
             340                345                350
Ile Gln Lys Val Gln Val Val Val Thr Val Leu Asp Tyr Asp Lys Leu 
         355                360                365
Gly Lys Asn Glu Ala Ile Gly Lys Ile Phe Val Gly Ser Asn Ala Thr 
     370                375                380
Gly Thr Glu Leu Arg His Trp Ser Asp Met Leu Ala Asn Pro Arg Arg 
 385                390                395                400
Pro Ile Ala Gln Trp His Ser Leu Lys Pro Glu Glu Glu Val Asp Ala 
                 405                410                415
Leu Leu Gly Lys Asn Lys 
             420



<210> 3833
<211> 2050
<212> DNA
<213> Homo sapiens
<308> XM_012840
<400> 3833

cccaggcac  ggtgggccc  ggagcgagc  tgccccgcc  ggactccgc  tctgtgcgt  60
agccccgcc  gttgtcctg  caacaaccc  ttgcccggg  aaccagctt  gctctcacc  120
cgcttgaga  gagcccggc  gttgctctg  gcaacgcgg  ctgctggtt  ccacgtctg  180
cttcgcccg  ttccggttc  gaccctgcg  aggggcgag  acgaggcag  agtcagcgg  240
atgcctgtg  ggccgtgga  gaagagggt  tccctttag  atggaacta  gtcctggac  300
ccccctctc  agtgcgggg  ggctgatac  acaactccc  gcatgactc  cggtggctg  360
ccggtttct  cgcggctgt  cgcgcaaag  cctcatggg  gttggagtt  tttgttgtg  420
gtggggctc  aaggacgtc  ggggtggga  tgggggact  gggtgcttg  gtgtctctg  480
agaaaagac  ccaggaccc  gccaccatg  tcccggagc  cccaacccc  gggcctcca  540
cgcccgaca  gcctcccga  tccagtcgc  tcagccacg  cccagtgcc  ccctgggcc  600
tggccacca  cgtgctggt  tcaggcctc  tcatcttca  ctgctgttt  tgtctctac  660
ggaagagct  tcggaggcg  acaggcaag  agagccagg  ccaagccca  gtccacctt  720
aggaagtga  ggggctggg  cagagttac  tagacaagg  gcagccaga  gtagaggag  780
tggagccag  accatccgg  ccagggcag  aggtggcag  caagcatga  ctaggacga  840
tgcagtact  cctggatta  gacttccag  gtggccagc  gctggtggg  attctgcaa  900
caatgggat  ggcagcctt  gatcttggt  gctcctcgg  cccctatgt  cgggtctac  960
tgctgccgg  caaacggag  cggtacgag  ccaaggtgc  tcggcagac  ctgaaccct  1020
actttgggg  gaccttcgc  ttcaaggtc  cctacgtgg  gctgggggg  agggtgctg  1080
tcatggcgg  gtacgactt  gaccgcttc  ctcgcaatg  cgccatcgg  gaggtgcgg  1140
tccctatga  ctccgtgga  ctggggcgg  cagtgcagg  ctggcggga  ctgcaggcg  1200
ctccgcggg  ggagcagga  aagcttggg  acatctgct  ctccctccg  tatgtcccc  1260
cggccggga  gctcaccgt  atcgtcctg  aggctaaaa  cctgaagaa  atggacgta  1320
gaggactgt  agatccata  gtcaaggtc  acctgctgc  gggcggcaa  aaggtgcgg  1380
agaagaaaa  caccatcaa  aagaacact  tgaacccct  ttacaacga  gctttcagc  1440
tcgaggtgc  ctgtgacca  gtccagaag  tgcaggtgg  gctgaccgt  ctggactac  1500
acaagctgg  caagaacga  gccatcggg  gggtggccg  gggggcggc  gccggcggg  1560
ctggcctgc  gcactgggc  gacatgctg  ccaacccgc  gcggcccat  gcccagtgg  1620
actcgctgc  gcccccgga  cgagtgagg  tgctgcctg  gccctgact  ccaccccaa  1680
cccccggcc  agcctggac  ctagcccct  accccagac  cccgagacc  gccaaagcc  1740
agccagccc  acccttaag  ttcctctga  ggttaccct  cccccacct  ccaccccaa  1800
catctgaac  attcctgtc  tctcacccc  aacgatgcc  atcacgaca  ctttccagc  1860
cactccccc  accctcgcg  acacaccca  atgccccag  gaccccggg  agggaaggc  1920
gcctggttt  tcctgcccc  gggtcctgc  ccctgcttt  acaatcagc  atcctcgtc  1980
gctctcctc  ctcttccaa  acagcccat  cctgcactg  tcctggggc  aaataaata  2040
tcagcagctc  2050



<210> 3834
<211> 386
<212> PRT
<213> Homo sapiens
<308> XP_012840
<400> 3834

Met Phe Pro Glu Pro Pro Thr Pro Gly Pro Pro Ser Pro Asp Thr Pro 
  1               5                  10                  15
Pro Asp Ser Ser Arg Ile Ser His Gly Pro Val Pro Pro Trp Ala Leu 
             20                  25                  30
Ala Thr Ile Val Leu Val Ser Gly Leu Leu Ile Phe Ser Cys Cys Phe 
         35                  40                  45
Cys Leu Tyr Arg Lys Ser Cys Arg Arg Arg Thr Gly Lys Lys Ser Gln 
     50                  55                  60
Ala Gln Ala Gln Val His Leu Gln Glu Val Lys Gly Leu Gly Gln Ser 
 65                  70                  75                  80
Tyr Ile Asp Lys Val Gln Pro Glu Val Glu Glu Leu Glu Pro Ala Pro 
                 85                  90                  95
Ser Gly Pro Gly Gln Gln Val Ala Asp Lys His Glu Leu Gly Arg Leu 
             100                105                110
Gln Tyr Ser Leu Asp Tyr Asp Phe Gln Ser Gly Gln Leu Leu Val Gly 
         115                120                125
Ile Leu Gln Ala Met Gly Leu Ala Ala Leu Asp Leu Gly Gly Ser Ser 
     130                135                140
Asp Pro Tyr Val Arg Val Tyr Leu Leu Pro Asp Lys Arg Arg Arg Tyr 
 145                150                155                160
Glu Thr Lys Val His Arg Gln Thr Leu Asn Pro His Phe Gly Glu Thr 
                 165                170                175
Phe Ala Phe Lys Val Pro Tyr Val Glu Leu Gly Gly Arg Val Leu Val 
             180                185                190
Met Ala Val Tyr Asp Phe Asp Arg Phe Ser Arg Asn Asp Ala Ile Gly 
         195                200                205
Glu Val Arg Val Pro Met Ser Ser Val Asp Leu Gly Arg Pro Val Gln 
     210                215                220
Ala Trp Arg Glu Leu Gln Ala Ala Pro Arg Glu Glu Gln Glu Lys Leu 
 225                230                235                240
Gly Asp Ile Cys Phe Ser Leu Arg Tyr Val Pro Thr Ala Gly Lys Leu 
                 245                250                255
Thr Val Ile Val Leu Glu Ala Lys Asn Leu Lys Lys Met Asp Val Gly 
             260                265                270
Gly Leu Ser Asp Pro Tyr Val Lys Val His Leu Leu Gln Gly Gly Lys 
         275                280                285
Lys Val Arg Lys Lys Lys Thr Thr Ile Lys Lys Asn Thr Leu Asn Pro 
     290                295                300
Tyr Tyr Asn Glu Ala Phe Ser Phe Glu Val Pro Cys Asp Gln Val Gln 
 305                310                315                320
Lys Val Gln Val Glu Leu Thr Val Leu Asp Tyr Asp Lys Leu Gly Lys 
                 325                330                335
Asn Glu Ala Ile Gly Arg Val Ala Val Gly Ala Ala Ala Gly Gly Ala 
             340                345                350
Gly Leu Arg His Trp Ala Asp Met Leu Ala Asn Pro Arg Arg Pro Ile 
         355                360                365
Ala Gln Trp His Ser Leu Arg Pro Pro Asp Arg Val Arg Leu Leu Pro 
     370                375                380
Ala Pro 
 385



<210> 3836
<211> 447
<212> PRT
<213> Rattus norvegicus
<308> AAA42299
<400> 3836

Met Lys Ile Leu Leu Leu Cys Val Ala Leu Leu Leu Thr Trp Asp Asn 
  1               5                  10                  15
Gly Met Val Leu Gly Glu Gln Glu Phe Ser Asp Asn Glu Leu Gln Glu 
             20                  25                  30
Leu Ser Thr Gln Gly Ser Arg Tyr Val Asn Lys Glu Ile Gln Asn Ala 
         35                  40                  45
Val Gln Gly Val Lys His Ile Lys Thr Leu Ile Glu Lys Thr Asn Ala 
     50                  55                  60
Glu Arg Lys Ser Leu Leu Asn Ser Leu Glu Glu Ala Lys Lys Lys Lys 
 65                  70                  75                  80
Glu Gly Ala Leu Asp Asp Thr Arg Asp Ser Glu Met Lys Leu Lys Ala 
                 85                  90                  95
Phe Pro Glu Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys 
             100                105                110
Lys Pro Cys Leu Lys His Thr Cys Met Lys Phe Tyr Ala Arg Val Cys 
         115                120                125
Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn 
     130                135                140
Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser 
 145                150                155                160
Leu Leu Glu Ser Asp Arg Gln Gln Ser Gln Val Leu Asp Ala Met Gln 
                 165                170                175
Asp Ser Phe Thr Arg Ala Ser Gly Ile Ile Asp Thr Leu Phe Gln Asp 
             180                185                190
Arg Phe Phe Thr His Glu Pro Gln Asp Ile His His Phe Ser Pro Met 
         195                200                205
Gly Phe Pro His Lys Arg Pro His Phe Leu Tyr Pro Lys Ser Arg Leu 
     210                215                220
Val Arg Ser Leu Met Pro Leu Ser His Tyr Gly Pro Leu Ser Phe His 
 225                230                235                240
Asn Met Phe Gln Pro Phe Phe Asp Met Ile His Gln Ala Gln Gln Ala 
                 245                250                255
Met Asp Val Gln Leu His Ser Pro Ala Leu Gln Phe Pro Asp Val Asp 
             260                265                270
Phe Leu Lys Glu Gly Glu Asp Asp Pro Thr Val Cys Lys Glu Ile Arg 
         275                280                285
His Asn Ser Thr Gly Cys Leu Lys Met Lys Gly Gln Cys Glu Lys Cys 
     290                295                300
Gln Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ala Gln Ala 
 305                310                315                320
Asn Leu Arg Gln Glu Leu Asn Asp Ser Leu Gln Val Ala Glu Arg Leu 
                 325                330                335
Thr Gln Gln Tyr Asn Glu Leu Leu His Ser Leu Gln Ser Lys Met Leu 
             340                345                350
Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Asp Gln Phe Thr Trp Val 
         355                360                365
Ser Gln Leu Ala Asn Leu Thr Gln Gly Asp Asp Gln Tyr Leu Arg Val 
     370                375                380
Ser Thr Val Thr Thr His Ser Ser Asp Ser Glu Val Pro Ser Arg Val 
 385                390                395                400
Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr Val Val 
                 405                410                415
Leu Pro Glu Glu Val Ser Lys Asp Asn Pro Lys Phe Met Asp Thr Val 
             420                425                430
Ala Glu Lys Ala Leu Gln Glu Tyr Arg Arg Lys Ser Arg Met Glu 
         435                440                445



<210> 3837
<211> 2060
<212> DNA
<213> Rattus norvegicus
<308> M64755
<400> 3837

ctgtacctt  tcaccagcg  gtctgaacc  tctctgaac  ttcctgaag  tggaagatt  60
caccctgat  gctgactca  aaccactca  aaccctgga  ggggaccct  tggctgtgg  120
ggctttgct  cgggacgtg  ttgggattg  cgtagatga  gccattcgg  aggggacca  180
tgcctctga  aaggtctgc  aatggaagg  gcctgaaga  ctcaagcag  tgctggact  240
ggagctgca  agccagggc  agtctaggg  gcggatcct  gagcgctgc  gggctgtga  300
tcattacag  gtcaagact  gtcaccccc  gttcttcaa  cagctcttc  caggattag  360
tccccatgc  ctggccggg  gcatcatta  ggagagcct  aataccagc  agtacacat  420
tgagattgc  cccgtgttt  tgctcatgg  agaggaggt  ctgaagaaa  tccgtgccc  480
tgtgggctg  aacactggg  atggggtct  ctgtcctgg  ggttccatc  ctaacatgt  540
cgccataaa  ctggcccgc  ttcagcgct  cccagactg  aagcagagg  gcctccggg  600
cctgccacc  ttggccctc  tcacttcaa  ggagtgcca  tactccatc  ccaagggag  660
tgcttttct  ggacttggc  ccgacagtg  ccgagtggt  aaggctgat  agagaggga  720
gatgatccc  gaggatctg  agaggcaga  cagtctggc  gaggctgag  gctcggtgc  780
atttctggt  agtgccacc  ctggtacca  cgtgctagg  gcctttgac  ccctggatg  840
aattgccga  gtttgccag  gtcacgggc  gtggttaca  gtggatgcc  cctggggtg  900
gagcgtcct  ctgtcccgg  cacacaggc  tctcctgga  gggatccag  gggctgact  960
cgtggcctg  aaccctcac  agcttctcg  cgcggggct  cagtgctct  ctcttcttc  1020
ccgggacac  tcgaacctg  tcaagcgct  ccacgggtc  caggccagc  acctcttcc  1080
gcaagacaa  ttctacaac  tggctctgg  caccggaga  aaggtggtg  agtgtggcc  1140
ccgcgtgga  tgtctgaag  tgtggctca  gtggaaggc  cagggtggg  aagggctgg  1200
gtggcgcat  gaccaggcc  ttgctctca  tcggtactt  gtggaggag  taaaaaagc  1260
ggaaggatt  gagttggtc  tggagcccg  gttcgtcaa  gtgtgcttc  ggtttgtgc  1320
tcccagcct  cgggggaag  aggagagcc  agattacag  cagaggctg  ctcaggtgg  1380
ccctgtgct  aaggagcgc  tggtgaaga  gggaaccat  atgatcggc  accagccca  1440
gggacccgg  ccaacttct  ccgaatggt  gtggccaac  ccatactgg  ccaggccga  1500
atagacttc  ttctgggcg  gctggagcg  ctgggccag  acctgtgag  tgcttcctc  1560
ctctgcccc  cccaagctc  gcataagct  ctgggttcc  aaaagcgac  tttctagga  1620
acagtggcc  tgactgtgt  agcccccac  cactaactc  cctagctaa  tattggctg  1680
caggacggt  tctaagcac  ctacagtct  ttcttacga  atgtgcttc  tttaagtcg  1740
tcatagtgg  acacaccgt  aataccagc  ctggggagg  agaggcaga  acaagcaga  1800
ctcttgagt  tgaggccag  ctggtctac  gagctggcc  acacagaaa  aaaaacctg  1860
ctcaaaaaa  aagaaagga  ggaagaaag  aaggaaaag  aagaaatat  tttcattaa  1920
attatgtct  taaaaaatt  ttattaata  gagagatat  gtacgatgt  ttaagaaag  1980
tagatatgg  ggttgggga  ttagctcag  ggtagagcc  ttgcctagg  agcgcaagg  2040
cctgggttc  gtccccagct  2060



<210> 3838
<211> 493
<212> PRT
<213> Rattus norvegicus
<308> Q64611
<400> 3838

Met Ala Asp Ser Lys Pro Leu Arg Thr Leu Asp Gly Asp Pro Val Ala 
  1               5                  10                  15
Val Glu Ala Leu Leu Arg Asp Val Phe Gly Ile Val Val Asp Glu Ala 
             20                  25                  30
Ile Arg Lys Gly Thr Asn Ala Ser Glu Lys Val Cys Glu Trp Lys Glu 
         35                  40                  45
Pro Glu Glu Leu Lys Gln Leu Leu Asp Leu Glu Leu Gln Ser Gln Gly 
     50                  55                  60
Glu Ser Arg Glu Arg Ile Leu Glu Arg Cys Arg Ala Val Ile His Tyr 
 65                  70                  75                  80
Ser Val Lys Thr Gly His Pro Arg Phe Phe Asn Gln Leu Phe Ser Gly 
                 85                  90                  95
Leu Asp Pro His Ala Leu Ala Gly Arg Ile Ile Thr Glu Ser Leu Asn 
             100                105                110
Thr Ser Gln Tyr Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Met Glu 
         115                120                125
Glu Glu Val Leu Lys Lys Leu Arg Ala Leu Val Gly Trp Asn Thr Gly 
     130                135                140
Asp Gly Val Phe Cys Pro Gly Gly Ser Ile Ser Asn Met Tyr Ala Ile 
 145                150                155                160
Asn Leu Ala Arg Phe Gln Arg Tyr Pro Asp Cys Lys Gln Arg Gly Leu 
                 165                170                175
Arg Ala Leu Pro Pro Leu Ala Leu Phe Thr Ser Lys Glu Cys His Tyr 
             180                185                190
Ser Ile Thr Lys Gly Ala Ala Phe Leu Gly Leu Gly Thr Asp Ser Val 
         195                200                205
Arg Val Val Lys Ala Asp Glu Arg Gly Lys Met Ile Pro Glu Asp Leu 
     210                215                220
Glu Arg Gln Ile Ser Leu Ala Glu Ala Glu Gly Ser Val Pro Phe Leu 
 225                230                235                240
Val Ser Ala Thr Ser Gly Thr Thr Val Leu Gly Ala Phe Asp Pro Leu 
                 245                250                255
Asp Ala Ile Ala Asp Val Cys Gln Arg His Gly Leu Trp Leu His Val 
             260                265                270
Asp Ala Ala Trp Gly Gly Ser Val Leu Leu Ser Arg Thr His Arg His 
         275                280                285
Leu Leu Asp Gly Ile Gln Arg Ala Asp Ser Val Ala Trp Asn Pro His 
     290                295                300
Lys Leu Leu Ala Ala Gly Leu Gln Cys Ser Ala Leu Leu Leu Arg Asp 
 305                310                315                320
Thr Ser Asn Leu Leu Lys Arg Cys His Gly Ser Gln Ala Ser Tyr Leu 
                 325                330                335
Phe Gln Gln Asp Lys Phe Tyr Asn Val Ala Leu Asp Thr Gly Asp Lys 
             340                345                350
Val Val Gln Cys Gly Arg Arg Val Asp Cys Leu Lys Leu Trp Leu Met 
         355                360                365
Trp Lys Ala Gln Gly Gly Gln Gly Leu Glu Trp Arg Ile Asp Gln Ala 
     370                375                380
Phe Ala Leu Thr Arg Tyr Leu Val Glu Glu Ile Lys Lys Arg Glu Gly 
 385                390                395                400
Phe Glu Leu Val Met Glu Pro Glu Phe Val Asn Val Cys Phe Trp Phe 
                 405                410                415
Val Pro Pro Ser Leu Arg Gly Lys Lys Glu Ser Pro Asp Tyr Ser Gln 
             420                425                430
Arg Leu Ser Gln Val Ala Pro Val Leu Lys Glu Arg Met Val Lys Lys 
         435                440                445
Gly Thr Met Met Ile Gly Tyr Gln Pro His Gly Thr Arg Ala Asn Phe 
     450                455                460
Phe Arg Met Val Val Ala Asn Pro Ile Leu Val Gln Ala Asp Ile Asp 
 465                470                475                480
Phe Leu Leu Gly Glu Leu Glu Arg Leu Gly Gln Asp Leu 
                 485                490



<210> 3839
<211> 2152
<212> DNA
<213> Homo sapiens
<308> AF116545
<400> 3839

gcttgggga  gcacggaga  gtgcagctg  ggtggctca  acctgtagt  ccagcacgt  60
gggaggccg  ggagctacc  gtgcaccct  cctccggct  tcctgagca  agagatcct  120
atggctgac  cagaagcac  cccctccct  gctggggac  cagtggctg  ggaagcctt  180
ctccgggcc  tgtttgggg  tgttgtgga  gaggccatt  agaaaggaa  cagtgtctc  240
cagaaggtc  gtgagtgga  ggagcctga  gagctgaag  agctgctgg  tttggagct  300
cggagccag  gcgagtcac  gaagcagat  ctggagcgg  gtcgggctg  gattcgcta  360
agtgtcaag  ctggtcacc  tcggttctt  aaccagctc  tctctgggt  ggatcccca  420
gctctggcc  ggcgcatta  cactgagag  ctcaacacc  gccagtaca  atatgaaat  480
gcccccgtg  ttgtgctca  ggaagagga  gtgctgagg  aactgcggg  cctggtggg  540
tggagctct  gggacggaa  cttctgccc  ggtggctcc  tctccaaca  gtatgctgt  600
aatctggcc  gctatcagc  ctacccgga  tgcaagcag  ggggcctcc  cacactgcc  660
cccctggcc  tattcacat  gaaggaggt  gggaagagg  acaggccca  ccctgggct  720
ctgattcta  tctccagcc  tgtcactac  ccatccaga  gggagctgc  tttctggga  780
ttggcaccg  cagtgtccg  gtggtcaag  ctgatgaga  agggaaaat  gtccccgag  840
atctggaga  gcagattgg  atggccgag  ctgagggtg  tgtgccgtt  ctggtcagt  900
ccacctctg  caccactgt  ctaggggcc  ttgaccccc  ggaggcaat  gctgatgtg  960
gccagcgtc  tgggctatg  ctgcatgtg  atggctgac  ctgtggcct  gaatcccca  1020
aagctcctc  cagcaggcc  gcaatgctc  gcacttctt  tccaggata  ctcgaacct  1080
ctcaagcgc  gccatgggt  ccaggccag  taccttttc  agcaggaca  gttctacga  1140
gtggctctg  acacgggag  caaggtggt  cagtgtggc  gccgtgcgg  ctgtctgaa  1200
ctgtggctc  tgtggaagg  acagggcga  caagggctg  agcggcgca  cgaccaggc  1260
tttgtcctt  cccggtacc  ggtggagga  atgaagaag  gggaagggt  tgagctagt  1320
atggagcct  agtttgtca  tgtgtgttt  tggttcgta  cccccagcc  gcgagggaa  1380
caggagagt  cagattacc  cgaaaggct  tcaaaggtg  ctcacgcct  taatcccag  1440
actttggga  gccgaggcg  atggatcac  tgaggtcag  agttcgaga  cagcctggc  1500
aataaggtg  aaccctgtc  ctactaaaa  tacaaaaat  agccgagca  ggtggcctg  1560
gcctgtaaa  ccagctact  aggaggttg  ggcagaatt  cttgaaccc  gggggcaga  1620
gttgcagtg  gccgagatt  cacccctgc  ctccaggct  ggcaacagt  cgagactct  1680
ttccaaaaa  aataaaaaa  aacagcctt  ttaggccac  gtgacctgc  caatgttta  1740
atgctttga  ctactaact  tctcctaac  aaatatttg  ttttaggag  gtgtttaaa  1800
aaattacag  atgtctata  gatgaaatg  tattttgcc  ttaaaattt  gtttacaaa  1860
ataattttt  ttgacataa  aataacttt  atgtaattt  tgttgaaaa  gctgaatac  1920
agtctttat  tagagtaat  tttgagctg  gttcaaaaa  acataggaa  agactgata  1980
aatgaaata  ggcaaaatg  taatagttt  ccctggaat  ggataatag  caattttaa  2040
acagactcc  ttaaaaaaa  aaacaaaca  aaaaaacat  gacttcttt  tatcttttg  2100
gctccctcc  ttttattat  taatgaata  gtgttgctt  tgtaatagg  aa  2152



<210> 3840
<211> 493
<212> PRT
<213> Homo sapiens
<308> Q9Y600
<400> 3840

Met Ala Asp Ser Glu Ala Leu Pro Ser Leu Ala Gly Asp Pro Val Ala 
  1               5                  10                  15
Val Glu Ala Leu Leu Arg Ala Val Phe Gly Val Val Val Asp Glu Ala 
             20                  25                  30
Ile Gln Lys Gly Thr Ser Val Ser Gln Lys Val Cys Glu Trp Lys Glu 
         35                  40                  45
Pro Glu Glu Leu Lys Gln Leu Leu Asp Leu Glu Leu Arg Ser Gln Gly 
     50                  55                  60
Glu Ser Gln Lys Gln Ile Leu Glu Arg Cys Arg Ala Val Ile Arg Tyr 
 65                  70                  75                  80
Ser Val Lys Thr Gly His Pro Arg Phe Phe Asn Gln Leu Phe Ser Gly 
                 85                  90                  95
Leu Asp Pro His Ala Leu Ala Gly Arg Ile Ile Thr Glu Ser Leu Asn 
             100                105                110
Thr Ser Gln Tyr Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Met Glu 
         115                120                125
Glu Glu Val Leu Arg Lys Leu Arg Ala Leu Val Gly Trp Ser Ser Gly 
     130                135                140
Asp Gly Ile Phe Cys Pro Gly Gly Ser Ile Ser Asn Met Tyr Ala Val 
 145                150                155                160
Asn Leu Ala Arg Tyr Gln Arg Tyr Pro Asp Cys Lys Gln Arg Gly Leu 
                 165                170                175
Arg Thr Leu Pro Pro Leu Ala Leu Phe Thr Ser Lys Glu Cys His Tyr 
             180                185                190
Ser Ile Gln Lys Gly Ala Ala Phe Leu Gly Leu Gly Thr Asp Ser Val 
         195                200                205
Arg Val Val Lys Ala Asp Glu Arg Gly Lys Met Val Pro Glu Asp Leu 
     210                215                220
Glu Arg Gln Ile Gly Met Ala Glu Ala Glu Gly Ala Val Pro Phe Leu 
 225                230                235                240
Val Ser Ala Thr Ser Gly Thr Thr Val Leu Gly Ala Phe Asp Pro Leu 
                 245                250                255
Gly Ala Ile Ala Asp Val Cys Gln Arg His Gly Leu Trp Leu His Val 
             260                265                270
Asp Ala Ala Trp Gly Gly Ser Val Leu Leu Ser Gln Thr His Arg His 
         275                280                285
Leu Leu Asp Gly Ile Gln Arg Ala Asp Ser Val Ala Trp Asn Pro His 
     290                295                300
Lys Leu Leu Ala Ala Gly Leu Gln Cys Ser Ala Leu Leu Leu Gln Asp 
 305                310                315                320
Thr Ser Asn Leu Leu Lys Arg Cys His Gly Ser Gln Ala Ser Tyr Leu 
                 325                330                335
Phe Gln Gln Asp Lys Phe Tyr Asp Val Ala Leu Asp Thr Gly Asp Lys 
             340                345                350
Val Val Gln Cys Gly Arg Arg Val Asp Cys Leu Lys Leu Trp Leu Met 
         355                360                365
Trp Lys Ala Gln Gly Asp Gln Gly Leu Glu Arg Arg Ile Asp Gln Ala 
     370                375                380
Phe Val Leu Ala Arg Tyr Leu Val Glu Glu Met Lys Lys Arg Glu Gly 
 385                390                395                400
Phe Glu Leu Val Met Glu Pro Glu Phe Val Asn Val Cys Phe Trp Phe 
                 405                410                415
Val Pro Pro Ser Leu Arg Gly Lys Gln Glu Ser Pro Asp Tyr His Glu 
             420                425                430
Arg Leu Ser Lys Val Ala Pro Val Leu Lys Glu Arg Met Val Lys Glu 
         435                440                445
Gly Ser Met Met Ile Gly Tyr Gln Pro His Gly Thr Arg Gly Asn Phe 
     450                455                460
Phe Arg Val Val Val Ala Asn Ser Ala Leu Thr Cys Ala Asp Met Asp 
 465                470                475                480
Phe Leu Leu Asn Glu Leu Glu Arg Leu Gly Gln Asp Leu 
                 485                490



<210> 3841
<211> 1739
<212> DNA
<213> Rattus norvegicus
<308> M64797
<400> 3841

caaataaga  aaatctggt  gagtgagcc  ggggatggc  tccccacgg  aactgaccc  60
gaatcccct  aagaagatc  ggatgccat  cagcaatgg  aggcccgcc  tgcacgcca  120
ccaacgtgg  gtctgcatg  ccaactgcc  gacactcat  gtcatggtg  gcctgccag  180
caggggcaa  acctacatt  ctaagaagc  gacccggta  ctcaactgg  ttggcgtgc  240
tactcggga  ttcaacgtg  gtcagtatc  ccgggacat  gtcaagaca  acaaatctt  300
tgagttctt  ctcccagac  atgaagagg  cctgaaaat  aggaagcag  gtgccttgg  360
agccctcaa  gacgtccgg  agttcctca  tgaggaggg  ggacacgtg  cggtttttg  420
tgctaccaa  accacccga  aacggagag  gatgatctt  aactttgga  aacagaatg  480
ctataagac  ttctttgtt  aatctatct  tgtggatcc  gaggtcatt  ctgccaaca  540
cgtgcaagt  aagctgggc  gccctgact  tgtgaaccg  gacagcgac  aagccactg  600
ggacttcat  aggcgcatt  aatgctatg  aaactccta  gagtctctg  atgaagaac  660
ggacaggga  ctgtcctac  tcaagatca  ggacgtggg  cagagttat  tggtgaacc  720
tgttgccga  cacatccag  gtcgcatcg  ttattacct  atgaacatc  atgtgacac  780
ccgctccat  tacctctgc  ggcacgggg  gagtgagct  aacctcaag  gccggattg  840
tggggaccc  ggactctcc  cccggggcc  ggagttttc  aagcaccta  ctcagttca  900
cagtgacca  aacatcaag  acctgaagg  ctggacgag  cagatgaag  ggacgatcc  960
gacagccga  gcgctgagt  tcccttatg  gcagtggaa  gtcctcaac  agattgacg  1020
gggtgtctg  gaggaaatg  cctacgaag  aatccagga  cactacccg  tggagtttg  1080
tctgaggga  caggacaag  accggtacc  ctacccgaa  ggcgagtcc  atgaagacc  1140
ggtgcagcg  ctggagcct  tcatcatgg  gctggagag  caggagaac  tgctagtca  1200
ttgccacca  gctgtgatg  gttgcctcc  ggcctactt  cttgacaag  cagcagaag  1260
gctgcccta  ctcaaatgc  ccttgcaca  agtcctgaa  ctcacacct  tggcttacg  1320
ttgtaaagt  gagtccata  tcctgaatg  ggcagctgt  aacacacac  gagacagac  1380
tcagaatgt  gacatatcc  ggccttcag  ggaagccct  gtcacagtt  ctgctcacc  1440
atgacccat  gcaggccct  acctctgcg  aggggtcac  ccaggccac  tcttcctgt  1500
tgctgtatg  acggtcacc  tgcaggaac  ctcatgggt  gctggtaac  ctcagaacc  1560
tcagcctaa  ccacctgcc  ccttggtga  aaccagtga  ggggttgag  gtggctgct  1620
acctgctgc  gagaatctc  gggctacgt  ctctgctgc  ggccccttt  ctacagctc  1680
caagcagtc  gccccccgg  ctggctgct  tgtgacatt  gcaacatta  atgagacac  1739



<210> 3842
<211> 468
<212> PRT
<213> Rattus norvegicus
<308> P25114
<400> 3842

Ala Ser Pro Arg Glu Leu Thr Gln Asn Pro Leu Lys Lys Ile Trp Met 
  1               5                  10                  15
Pro Tyr Ser Asn Gly Arg Pro Ala Leu His Ala Ser Gln Arg Gly Val 
             20                  25                  30
Cys Met Thr Asn Cys Pro Thr Leu Ile Val Met Val Gly Leu Pro Ala 
         35                  40                  45
Arg Gly Lys Thr Tyr Ile Ser Lys Lys Leu Thr Arg Tyr Leu Asn Trp 
     50                  55                  60
Ile Gly Val Pro Thr Arg Glu Phe Asn Val Gly Gln Tyr Arg Arg Asp 
 65                  70                  75                  80
Met Val Lys Thr Tyr Lys Ser Phe Glu Phe Phe Leu Pro Asp Asn Glu 
                 85                  90                  95
Glu Gly Leu Lys Ile Arg Lys Gln Cys Ala Leu Ala Ala Leu Asn Asp 
             100                105                110
Val Arg Lys Phe Leu Ser Glu Glu Gly Gly His Val Ala Val Phe Asp 
         115                120                125
Ala Thr Asn Thr Thr Arg Glu Arg Arg Ala Met Ile Phe Asn Phe Gly 
     130                135                140
Glu Gln Asn Gly Tyr Lys Thr Phe Phe Val Glu Ser Ile Cys Val Asp 
 145                150                155                160
Pro Glu Val Ile Ala Ala Asn Ile Val Gln Val Lys Leu Gly Ser Pro 
                 165                170                175
Asp Tyr Val Asn Arg Asp Ser Asp Glu Ala Thr Glu Asp Phe Met Arg 
             180                185                190
Arg Ile Glu Cys Tyr Glu Asn Ser Tyr Glu Ser Leu Asp Glu Glu Gln 
         195                200                205
Asp Arg Asp Leu Ser Tyr Ile Lys Ile Met Asp Val Gly Gln Ser Tyr 
     210                215                220
Val Val Asn Arg Val Ala Asp His Ile Gln Ser Arg Ile Val Tyr Tyr 
 225                230                235                240
Leu Met Asn Ile His Val Thr Pro Arg Ser Ile Tyr Leu Cys Arg His 
                 245                250                255
Gly Glu Ser Glu Leu Asn Leu Lys Gly Arg Ile Gly Gly Asp Pro Gly 
             260                265                270
Leu Ser Pro Arg Gly Arg Glu Phe Ser Lys His Leu Ala Gln Phe Ile 
         275                280                285
Ser Asp Gln Asn Ile Lys Asp Leu Lys Val Trp Thr Ser Gln Met Lys 
     290                295                300
Arg Thr Ile Gln Thr Ala Glu Ala Leu Ser Val Pro Tyr Glu Gln Trp 
 305                310                315                320
Lys Val Leu Asn Glu Ile Asp Ala Gly Val Cys Glu Glu Met Thr Tyr 
                 325                330                335
Glu Glu Ile Gln Asp His Tyr Pro Leu Glu Phe Ala Leu Arg Asp Gln 
             340                345                350
Asp Lys Tyr Arg Tyr Arg Tyr Pro Lys Gly Glu Ser Tyr Glu Asp Leu 
         355                360                365
Val Gln Arg Leu Glu Pro Val Ile Met Glu Leu Glu Arg Gln Glu Asn 
     370                375                380
Val Leu Val Ile Cys His Gln Ala Val Met Arg Cys Leu Leu Ala Tyr 
 385                390                395                400
Phe Leu Asp Lys Ala Ala Glu Glu Leu Pro Tyr Leu Lys Cys Pro Leu 
                 405                410                415
His Thr Val Leu Lys Leu Thr Pro Val Ala Tyr Gly Cys Lys Val Glu 
             420                425                430
Ser Ile Phe Leu Asn Val Ala Ala Val Asn Thr His Arg Asp Arg Pro 
         435                440                445
Gln Asn Val Asp Ile Ser Arg Pro Ser Glu Glu Ala Leu Val Thr Val 
     450                455                460
Pro Ala His Gln 
 465



<210> 3843
<211> 2436
<212> DNA
<213> Homo sapiens
<308> AF108765
<400> 3843

tccgactca  cccggcccc  ggatggcgt  cccacggga  ttgacacag  accccctga  60
gaagatctg  atgccatac  gcaatgggc  gcccgctct  cacgcttgc  agcgcggtg  120
gtgcatgac  aactgccca  ctctcattg  catggtggg  ctgcccgcc  ggggcaaga  180
ctacatctc  aagaagctg  ctcgatacc  gaactggat  ggtgtgccc  ctcgggagt  240
caatgttgg  cagtatcgc  gggacgtgg  caagaccta  aaatctttt  aattttttc  300
ccccgacaa  gaagagggc  tgaaaatca  gaagcagtg  gccctggca  ccctccgtg  360
cgtccggcg  ttccttagt  aggaggggg  acatgtggc  gtttttgat  ccacaaaca  420
cacccgaga  cggagagcg  ccatcttta  ttttggaga  cagaatggc  acaagacct  480
ttttgtcga  tccatctgt  tggatcctg  ggtcatagc  gccaacatc  tgcaagtga  540
actgggcag  cctgactat  tcaaccgcg  cagtgatga  gctacggag  acttcatga  600
gcgcattga  tgctatgag  actcctacg  gtcgctaga  gaggacctg  atagggacc  660
gtcctatat  aagatcatg  atgtgggcc  gagctacgt  gtgaaccgt  tggctgacc  720
catccagag  cgcatcgta  attacctca  gaacatcca  gtgaccccc  gctccatct  780
cctctgccg  cacggggag  gcgagctca  cctcaaggg  cggattggc  gggacccag  840
actgtcccc  cggggcagg  agtttgcca  gagtctagc  cagttcatc  gtgaccaaa  900
tatcaagga  ctgaaggtc  ggacaagcc  gatgaagag  acaatccag  cggctgagg  960
actgggtgt  ccctatgaa  agtggaagg  cctcaacga  atcgatgcg  gcgtctgtg  1020
ggaaatgac  tacgaggaa  ttcaggata  ttatccact  gagttcgcc  tgcgggacc  1080
ggacaagta  cggtaccgg  accctaaag  ggagtccta  gaggacctg  tccagagac  1140
ggagcctgt  atcatggag  tggagaggc  agagaatgt  ctggtcatc  gccaccagg  1200
tgtgatgcg  tgcctgctg  cctacttcc  cgacaaggc  gcagaacag  tgccctacc  1260
caagtgtcc  ctgcacaca  tcctgaagc  gactcctgt  gcatatggt  gtaaagtgg  1320
gtccatatt  ctgaacgtg  ctgctgtga  cacgcaccg  gacaggcct  agaacgtgg  1380
catctcaag  cctccagag  aagcccttg  cacggtgcc  gctcaccag  gaccatgtt  1440
atccactgt  accactagg  aggcactgc  ctctgcaga  ggggtcatt  caggccctc  1500
agtgtgtgt  atagtcacc  tgccatgca  ggatattct  gaagccaca  atggctggc  1560
gaacccaga  cccccaccc  agcccacct  gctctttgt  gacagtcgg  gacaaggtt  1620
tgcgtggct  ctgacctgc  gctaagagt  acttgacca  actgcatct  catgggctg  1680
gcggaggtt  cccagcccc  gtttcttcc  gcgcagctc  taggtgttc  ctctcgcca  1740
ctcagttgg  tttgtgaag  gtgaaaccc  acaatgtga  aggaaagtg  ttgctgtga  1800
gttcctact  tggcccagc  gcccagcat  gacctggtg  ctctccaca  ggcctctac  1860
atcctctct  tggccactt  ctgagccag  ggccaggtc  tcatggggc  ctgagcttc  1920
gctgcctct  gtgagaggg  gagcccttc  catccttac  caccaggaa  tagagcccc  1980
accacagca  atgcttcct  ggcagccac  ggccaggcc  ttgtatcca  gtcaccctt  2040
gttgtgggc  ttcatgaaa  caatgcgct  gcttcagca  attggatgc  cagaaacgt  2100
agggcaggg  gcagttgtg  tcgcccctc  ccagttgtg  atgtacccg  ctacttagg  2160
atgcttagg  gagctggtg  ccaggggtg  cccttcagg  ctgctctca  agtgaaacc  2220
cttcaagac  gggcaggaa  ttaccttcc  tggtgcaca  accgaagtg  tcgagggag  2280
gctgccgcc  cctctcccc  tccctggct  tggacactg  cagccaatg  ggaggcggc  2340
tctcccctg  tgctgcccg  gtccacaca  gaatgtaca  tggtggcag  aacatgcat  2400
tgccataaa  aattcagaa  caaaaaaaa  aaaaaa  2436



<210> 3844
<211> 468
<212> PRT
<213> Homo sapiens
<308> Q16877
<400> 3844

Ala Ser Pro Arg Glu Leu Thr Gln Asn Pro Leu Lys Lys Ile Trp Met 
  1               5                  10                  15
Pro Tyr Ser Asn Gly Arg Pro Ala Leu His Ala Cys Gln Arg Gly Val 
             20                  25                  30
Cys Met Thr Asn Cys Pro Thr Leu Ile Val Met Val Gly Leu Pro Ala 
         35                  40                  45
Arg Gly Lys Thr Tyr Ile Ser Lys Lys Leu Thr Arg Tyr Leu Asn Trp 
     50                  55                  60
Ile Gly Val Pro Thr Arg Glu Phe Asn Val Gly Gln Tyr Arg Arg Asp 
 65                  70                  75                  80
Val Val Lys Thr Tyr Lys Ser Phe Glu Phe Phe Leu Pro Asp Asn Glu 
                 85                  90                  95
Glu Gly Leu Lys Ile Arg Lys Gln Cys Ala Leu Ala Ala Leu Arg Asp 
             100                105                110
Val Arg Arg Phe Leu Ser Glu Glu Gly Gly His Val Ala Val Phe Asp 
         115                120                125
Ala Thr Asn Thr Thr Arg Glu Arg Arg Ala Thr Ile Phe Asn Phe Gly 
     130                135                140
Glu Gln Asn Gly Tyr Lys Thr Phe Phe Val Glu Ser Ile Cys Val Asp 
 145                150                155                160
Pro Glu Val Ile Ala Ala Asn Ile Val Gln Val Lys Leu Gly Ser Pro 
                 165                170                175
Asp Tyr Val Asn Arg Asp Ser Asp Glu Ala Thr Glu Asp Phe Met Arg 
             180                185                190
Arg Ile Glu Cys Tyr Glu Asn Ser Tyr Glu Ser Leu Asp Glu Asp Leu 
         195                200                205
Asp Arg Asp Leu Ser Tyr Ile Lys Ile Met Asp Val Gly Gln Ser Tyr 
     210                215                220
Val Val Asn Arg Val Ala Asp His Ile Gln Ser Arg Ile Val Tyr Tyr 
 225                230                235                240
Leu Met Asn Ile His Val Thr Pro Arg Ser Ile Tyr Leu Cys Arg His 
                 245                250                255
Gly Glu Ser Glu Leu Asn Leu Lys Gly Arg Ile Gly Gly Asp Pro Gly 
             260                265                270
Leu Ser Pro Arg Gly Arg Glu Phe Ala Lys Ser Leu Ala Gln Phe Ile 
         275                280                285
Ser Asp Gln Asn Ile Lys Asp Leu Lys Val Trp Thr Ser Gln Met Lys 
     290                295                300
Arg Thr Ile Gln Thr Ala Glu Ala Leu Gly Val Pro Tyr Glu Gln Trp 
 305                310                315                320
Lys Val Leu Asn Glu Ile Asp Ala Gly Val Cys Glu Glu Met Thr Tyr 
                 325                330                335
Glu Glu Ile Gln Asp Asn Tyr Pro Leu Glu Phe Ala Leu Arg Asp Gln 
             340                345                350
Asp Lys Tyr Arg Tyr Arg Tyr Pro Lys Gly Glu Ser Tyr Glu Asp Leu 
         355                360                365
Val Gln Arg Leu Glu Pro Val Ile Met Glu Leu Glu Arg Gln Glu Asn 
     370                375                380
Val Leu Val Ile Cys His Gln Ala Val Met Arg Cys Leu Leu Ala Tyr 
 385                390                395                400
Phe Leu Asp Lys Ala Ala Glu Gln Leu Pro Tyr Leu Lys Cys Pro Leu 
                 405                410                415
His Thr Val Leu Lys Leu Thr Pro Val Ala Tyr Gly Cys Lys Val Glu 
             420                425                430
Ser Ile Phe Leu Asn Val Ala Ala Val Asn Thr His Arg Asp Arg Pro 
         435                440                445
Gln Asn Val Asp Ile Ser Arg Pro Pro Glu Glu Ala Leu Val Thr Val 
     450                455                460
Pro Ala His Gln 
 465



<210> 3845
<211> 1225
<212> DNA
<213> Rattus norvegicus
<308> M64986
<400> 3845

gtctggctc  cgctctcac  gccattgca  tacattgag  tccatagag  cagcgccgg  60
gcaagcgag  gccggacgg  cactgggcg  ctctgtgcc  cgcggagga  aatcaacta  120
acatgggca  aggagatcc  aagaagccg  gaggcaaaa  gtcctcata  gcattcttt  180
tgcaaacct  ccgggagga  cacaagaag  agcacccgg  tgcttctgt  aacttctca  240
agttctcca  gaagtgctc  gagaggtgg  agaccatgt  tgctaaaga  aaggggaaa  300
ttgaagata  ggcaaaggc  gacaaggct  gttatgaaa  agaaatgaa  acctacatc  360
cccccaaag  ggagaccaa  aagaagttc  aggacccca  tgcccccaa  aggcctcct  420
cggccttct  cttgttctg  tctgagtac  gcccaaaaa  caaaggcga  catcctggc  480
tatccattg  tgatgttgc  aagaaacta  gagagatgt  gaacaacac  gctgcggat  540
acaagcagc  ctatgaaaa  aaggccgcc  agctgaagg  gaagtatga  aaggatatt  600
ctgcctaca  agctaaagg  aaacctgat  cagcgaaaa  gggggtggt  aaggctgag  660
agagcaaga  aaagaagga  gaggaagac  acgaggagg  tgaagagga  gaggaagag  720
aggaagaag  ggaagacga  gatgaagaa  aagatgatg  tgatgaata  gttggttct  780
cgcatgttt  tttttcttg  ctataaagc  tttaacccc  ctgtacaca  ctcactcct  840
ttaaagaaa  aaattgaaa  gtaaggctg  gtaagattt  tttttaaac  gtacagtgt  900
tttttttgt  tagttaaca  actaccgaa  gtgtcttta  ctagccctg  cctggtggt  960
ttttcaata  ccactaacc  tgcctggta  agtctgggg  ttgtaaatt  gcatggaaa  1020
taaagcagg  tcttgttgg  gcacagcac  aattagtta  atatgggga  agtagtttt  1080
gttttttgg  tttcttttt  tttttgtgt  tttgttttt  ttccttttt  ttttttttt  1140
catcttcag  tgtctctga  gcagattat  cgaaggtaa  tgttgttct  ttaactgaa  1200
accactctg  aattgcaaa  aaatg  1225



<210> 3846
<211> 214
<212> PRT
<213> Rattus norvegicus
<308> P07155
<400> 3846

Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
  1               5                  10                  15
Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
             20                  25                  30
Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
         35                  40                  45
Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys 
     50                  55                  60
Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro Pro 
 65                  70                  75                  80
Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg 
                 85                  90                  95
Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys Ile 
             100                105                110
Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu 
         115                120                125
Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu 
     130                135                140
Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
 145                150                155                160
Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys 
                 165                170                175
Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Asp Asp Glu Glu Asp 
             180                185                190
Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Glu 
         195                200                205
Glu Asp Asp Asp Asp Glu 
     210



<210> 3847
<211> 578
<212> DNA
<213> Homo sapiens
<308> AV701053
<400> 3847

cgcagcctt  tgaaaagaa  cctgcgaag  tgaaggaaa  atacgaaaa  gatattgct  60
catatcgag  taaaggaaa  cctgatgca  caaaaaaag  gagttgtca  ggctgaaaa  120
agcaagaaa  agaaggaag  ggaggaaga  gaggaagat  aagaggatg  ggaggagga  180
gaggatgaa  aagattttt  tcttgtcta  aaagcattt  acccccctg  acacaactc  240
ctcctttta  agaaaaaaa  tgaaatgta  ggctgtgta  gatttgttt  taaactgta  300
agtgtcttt  tttgtatag  taacacact  ccgaatgtg  ctttagata  ccctgtcct  360
gtggtattt  caatagcca  taaccttgc  tggtacagt  tgggggttg  aaattggca  420
ggaaattta  agcaggttc  tgttggtgc  cagcacaaa  tagttatat  tggggatgg  480
agttttttc  tcttcagtt  tctctgatg  agcttatac  aaataattg  tgttctgtt  540
actgaatac  actctgtaa  tgcaaaaaa  aaaaaaaa  578



<210> 3848
<211> 214
<212> PRT
<213> Homo sapiens
<308> P09429
<400> 3848

Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
  1               5                  10                  15
Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
             20                  25                  30
Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
         35                  40                  45
Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys 
     50                  55                  60
Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro Pro 
 65                  70                  75                  80
Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg 
                 85                  90                  95
Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys Ile 
             100                105                110
Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu 
         115                120                125
Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu 
     130                135                140
Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
 145                150                155                160
Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys 
                 165                170                175
Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu Asp 
             180                185                190
Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu Glu 
         195                200                205
Glu Asp Asp Asp Asp Glu 
     210



<210> 3849
<211> 1225
<212> DNA
<213> Rattus norvegicus
<308> M64986
<400> 3849

gtctggctc  cgctctcac  gccattgca  tacattgag  tccatagag  cagcgccgg  60
gcaagcgag  gccggacgg  cactgggcg  ctctgtgcc  cgcggagga  aatcaacta  120
acatgggca  aggagatcc  aagaagccg  gaggcaaaa  gtcctcata  gcattcttt  180
tgcaaacct  ccgggagga  cacaagaag  agcacccgg  tgcttctgt  aacttctca  240
agttctcca  gaagtgctc  gagaggtgg  agaccatgt  tgctaaaga  aaggggaaa  300
ttgaagata  ggcaaaggc  gacaaggct  gttatgaaa  agaaatgaa  acctacatc  360
cccccaaag  ggagaccaa  aagaagttc  aggacccca  tgcccccaa  aggcctcct  420
cggccttct  cttgttctg  tctgagtac  gcccaaaaa  caaaggcga  catcctggc  480
tatccattg  tgatgttgc  aagaaacta  gagagatgt  gaacaacac  gctgcggat  540
acaagcagc  ctatgaaaa  aaggccgcc  agctgaagg  gaagtatga  aaggatatt  600
ctgcctaca  agctaaagg  aaacctgat  cagcgaaaa  gggggtggt  aaggctgag  660
agagcaaga  aaagaagga  gaggaagac  acgaggagg  tgaagagga  gaggaagag  720
aggaagaag  ggaagacga  gatgaagaa  aagatgatg  tgatgaata  gttggttct  780
cgcatgttt  tttttcttg  ctataaagc  tttaacccc  ctgtacaca  ctcactcct  840
ttaaagaaa  aaattgaaa  gtaaggctg  gtaagattt  tttttaaac  gtacagtgt  900
tttttttgt  tagttaaca  actaccgaa  gtgtcttta  ctagccctg  cctggtggt  960
ttttcaata  ccactaacc  tgcctggta  agtctgggg  ttgtaaatt  gcatggaaa  1020
taaagcagg  tcttgttgg  gcacagcac  aattagtta  atatgggga  agtagtttt  1080
gttttttgg  tttcttttt  tttttgtgt  tttgttttt  ttccttttt  ttttttttt  1140
catcttcag  tgtctctga  gcagattat  cgaaggtaa  tgttgttct  ttaactgaa  1200
accactctg  aattgcaaa  aaatg  1225



<210> 3850
<211> 214
<212> PRT
<213> Rattus norvegicus
<308> P07155
<400> 3850

Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
  1               5                  10                  15
Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
             20                  25                  30
Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
         35                  40                  45
Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys 
     50                  55                  60
Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro Pro 
 65                  70                  75                  80
Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg 
                 85                  90                  95
Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys Ile 
             100                105                110
Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu 
         115                120                125
Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu 
     130                135                140
Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
 145                150                155                160
Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys 
                 165                170                175
Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Asp Asp Glu Glu Asp 
             180                185                190
Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Glu 
         195                200                205
Glu Asp Asp Asp Asp Glu 
     210



<210> 3851
<211> 578
<212> DNA
<213> Homo sapiens
<308> AV701053
<400> 3851

cgcagcctt  tgaaaagaa  cctgcgaag  tgaaggaaa  atacgaaaa  gatattgct  60
catatcgag  taaaggaaa  cctgatgca  caaaaaaag  gagttgtca  ggctgaaaa  120
agcaagaaa  agaaggaag  ggaggaaga  gaggaagat  aagaggatg  ggaggagga  180
gaggatgaa  aagattttt  tcttgtcta  aaagcattt  acccccctg  acacaactc  240
ctcctttta  agaaaaaaa  tgaaatgta  ggctgtgta  gatttgttt  taaactgta  300
agtgtcttt  tttgtatag  taacacact  ccgaatgtg  ctttagata  ccctgtcct  360
gtggtattt  caatagcca  taaccttgc  tggtacagt  tgggggttg  aaattggca  420
ggaaattta  agcaggttc  tgttggtgc  cagcacaaa  tagttatat  tggggatgg  480
agttttttc  tcttcagtt  tctctgatg  agcttatac  aaataattg  tgttctgtt  540
actgaatac  actctgtaa  tgcaaaaaa  aaaaaaaa  578



<210> 3852
<211> 214
<212> PRT
<213> Homo sapiens
<308> P09429
<400> 3852

Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
  1               5                  10                  15
Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
             20                  25                  30
Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
         35                  40                  45
Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys 
     50                  55                  60
Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro Pro 
 65                  70                  75                  80
Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg 
                 85                  90                  95
Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys Ile 
             100                105                110
Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu 
         115                120                125
Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu 
     130                135                140
Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
 145                150                155                160
Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys 
                 165                170                175
Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu Asp 
             180                185                190
Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu Glu 
         195                200                205
Glu Asp Asp Asp Asp Glu 
     210



<210> 3853
<211> 3774
<212> DNA
<213> Rattus norvegicus
<308> M65251
<400> 3853

gaattccgg  tgccagcgg  cctttccct  ccaacaggg  gatactttc  ggttccagg  60
cgccgccgc  acggaagtt  agtgggccc  cagaaagca  agagtcctc  gatgagctg  120
acatcgatg  gacctcgtc  gacatgagc  tgagccccc  gagctcttc  ctgcccaca  180
gaggcagtc  gcaggaaga  gaagggaag  cccgcaagc  gccagtcag  atgctagtc  240
acatggcct  tggtccggg  ggaaatgtg  caaattcca  tcttctttt  acagacgtg  300
cagatttcc  gcagatcct  cagttcccc  gtctgcgga  aacaactac  gtgagttgg  360
gcttcttaa  ttatacaaa  cccaatttt  tgcaacagg  caccttcaa  tcctccgtt  420
atgcttcat  gtgcattag  tcctgtaac  caaacccat  aggattgaa  accaagacc  480
cgctggccc  cctgagatc  aaacaaaaa  ttaccgccg  aatttacac  ctggctgct  540
tgcacaggc  cggaactgg  aagctcaca  catccagtg  ctggaagca  tttgcacag  600
tgaaacctg  tgcaccctt  ttgtttggc  acaaactag  aaggaaatt  gggggaaat  660
tcttaaagg  aagagggaa  ggagagatt  acggagata  agatcttgg  tccaaacaa  720
ccgagccaa  ccgaattaa  atctttgaa  gggggtaca  atccaatga  gattatgtg  780
atgtcagag  acgtggacg  ggaaagtac  tttgtgaag  gtgtggaat  cgctgtaag  840
agccaagca  gctgaaaaa  catatacgc  ctcatactg  tgttcggcc  tatgtatgc  900
agttatgta  ttttgcctt  aagacgaaa  gaaacctaa  gaaacacat  aaatctaag  960
cccacatga  aaagtgtct  gagctgggc  tctcgatga  atcagtaga  gagacagaa  1020
cagaagaag  agaaaatat  gaagatttg  acaaaacat  tgagaagca  agcatgtcc  1080
gcatttcaa  tgaccacca  ttctcagat  ctgaggaat  tgacggaga  gatggagac  1140
ataatgatg  agatgatga  gacgatgat  actttgatg  ccaaggaga  ttgacaccc  1200
aaacaaggt  aagaagcac  agtcctcag  ctcctcggt  ctcctcctt  cctgtcaat  1260
ttggcgctg  agcccacgg  gtcccctca  atagctctc  gggacattc  tcattgatc  1320
gctatttgg  tactctacc  agtattcag  tcactcagc  catgacacc  agtgactct  1380
gtgaagaca  ccagatgac  gaatatcag  ggctgttcc  gagcaaaag  acagactcc  1440
aacccgaca  agacaggtt  gacatccca  gctccatgg  cgaagaggc  atgttgtct  1500
cagagccaa  ctcctcccc  agggacttc  ccccctcaa  ctaccggtc  tcaccagga  1560
atgattctt  accctgtcg  gataattcg  caaagaggt  tctgatacc  aaaggagat  1620
tgtcaccca  aagacattt  tcacctaga  gagatctat  acccatgag  catctgtca  1680
caagaaaag  agctgcatt  aggagagag  tgtcccaag  ggatgcttc  ccaaggagg  1740
atttgtccc  acggagacc  ttgtctcct  gaaaagaca  tacaacaag  agggacctc  1800
ctcccagaa  agagagaag  tatatgact  ccattagag  accatctcc  agaagggct  1860
tataccata  cccaccatt  ccaatgggg  agtatctgc  aacagagcc  attgtattg  1920
ggcctccta  tctaagaag  ggattacct  aggttcctt  cttcagtct  tatggagac  1980
aagaaggtg  ttatgaaca  cacggctcc  gccttttcc  tgagggtcc  actgactat  2040
tcttcagtc  tcttcccct  cattctcag  agcaagtgc  agctcctat  cccatggtg  2100
cagttggtg  gatccaaat  gttcactcc  tgccgccag  catttccgg  ttacatcct  2160
cacccacat  gcctctgcc  acagagggc  ctgaggaga  gaaaggagc  cccggggag  2220
ccctcacca  ggatcccta  accctttcc  ggcggcatg  gaaacaagc  cctcacgtt  2280
tgcagtcat  tggtctacc  agttctccc  cctccccac  gctattgat  aaacagagt  2340
cttcagaag  cagcctaaa  tccacagag  gagaacagg  ggaaaacat  cagacttgt  2400
caaaagcca  cgcctcact  cggattgca  cagaagagg  agctctgct  ggggctgat  2460
agcccacat  ggtgcagga  tccccgcag  aacccttgg  gagtgcaca  atcagcatt  2520
gacacttta  cgggcctga  ccaggtcag  tctgtacct  agccgccca  cctgactta  2580
acgatggtg  aaaggacac  tttggtaca  cacagactg  agtagccca  cccacgttt  2640
acagcaagg  cagtgtgga  gagaagcag  tggactttc  gagcagcaa  gaattatct  2700
taagcacag  ggaaggcaa  gagccctca  cggaaaaga  tcgactcca  tgatctgca  2760
tgcatggac  cattcattt  cacatttcc  cctcccccc  tttgttttt  tttttctag  2820
gatagaaat  aacgagttg  tagcatgcc  gtcctaagt  acagtagtt  gctattata  2880
atacttttg  tattttgaa  acaattagg  aaattaacc  agtcgatct  gagcctgac  2940
aaaacaaaa  ttgaaatta  cctattggg  ctggtaact  tgaaaaaaa  tgtacagat  3000
tttgtgcct  ttctttact  tgtttatat  cttataagc  tttttttag  ggtaatttg  3060
atatatttt  gaatttgtg  atctgcttt  taataaatg  aatctcttt  ctcttttga  3120
acttggatc  taacgacgt  aagcaaagc  gcatctata  atattgtga  gttgcacta  3180
aacatattt  tatatgata  aactgaaca  cttttatgt  cagctctca  tctgtaata  3240
taatattta  tttgtttca  aaactgtac  tttttttct  aatgttgtg  attgctttt  3300
tatgtgaag  atggttccc  gttgcgtaa  tagaacaga  atgtccatg  aagcaanat  3360
tttaaacta  natatctta  tctgcactt  tgcataagt  acaaaaaaa  ataaagaag  3420
atcagtcgg  tcttaacct  taaattctt  ttgtctctt  tttgccgga  tgacaataa  3480
ttaagagct  attgtgatt  ttaaatgga  agtacgtaa  gcattaaag  aaacaatgt  3540
ctattgtga  tttttttca  agctttata  atcagttat  aataatatt  aagtatttg  3600
tcttatgtg  acatgttga  ctatatact  accttaaaa  atatgggaa  aacattccg  3660
ccccatgta  atatgtaca  gtgcatcac  ggtacagtt  tgtgttact  ggttggaca  3720
gaggttgcc  cagacctat  ctagagtgt  tttaaaatt  aagtgagaa  gcac  3774



<210> 3854
<211> 916
<212> PRT
<213> Rattus norvegicus
<308> Q00900
<400> 3854

Ile Pro Ala Ala Ser Gly Pro Phe Pro Pro Asn Arg Glu Ile Leu Ser 
  1               5                  10                  15
Gly Ser Arg Ala Pro Pro Arg Arg Lys Phe Ser Gly Pro Ser Glu Ser 
             20                  25                  30
Arg Glu Ser Ser Asp Glu Leu Asp Ile Asp Glu Thr Ser Ser Asp Met 
         35                  40                  45
Ser Met Ser Pro Gln Ser Ser Ser Leu Pro Thr Gly Gly Ser Gln Gln 
     50                  55                  60
Glu Asp Glu Gly Lys Ala Arg Lys Leu Pro Val Ser Met Leu Val His 
 65                  70                  75                  80
Met Ala Ser Gly Pro Gly Gly Asn Val Ala Asn Ser Thr Leu Leu Phe 
                 85                  90                  95
Thr Asp Val Ala Asp Phe Gln Gln Ile Leu Gln Phe Pro Ser Leu Arg 
             100                105                110
Thr Thr Thr Thr Val Ser Trp Cys Phe Leu Asn Tyr Thr Lys Pro Asn 
         115                120                125
Phe Val Gln Gln Ala Thr Phe Lys Ser Ser Val Tyr Ala Ser Trp Cys 
     130                135                140
Ile Ser Ser Cys Asn Pro Asn Pro Ser Gly Leu Asn Thr Lys Thr Thr 
 145                150                155                160
Leu Ala Leu Leu Arg Ser Lys Gln Lys Ile Thr Ala Glu Ile Tyr Thr 
                 165                170                175
Leu Ala Ala Met His Arg Pro Gly Thr Gly Lys Leu Thr Ser Ser Ser 
             180                185                190
Ala Trp Lys Gln Phe Ala Gln Met Lys Pro Asp Ala Pro Phe Leu Phe 
         195                200                205
Gly Asn Lys Leu Glu Arg Lys Leu Gly Gly Asn Val Leu Lys Glu Arg 
     210                215                220
Gly Lys Gly Glu Ile His Gly Asp Lys Asp Leu Gly Ser Lys Gln Thr 
 225                230                235                240
Glu Pro Ile Arg Ile Lys Ile Phe Glu Gly Gly Tyr Lys Ser Asn Glu 
                 245                250                255
Asp Tyr Val Tyr Val Arg Gly Arg Gly Arg Gly Lys Tyr Ile Cys Glu 
             260                265                270
Glu Cys Gly Ile Arg Cys Lys Lys Pro Ser Met Leu Lys Lys His Ile 
         275                280                285
Arg Thr His Thr Asp Val Arg Pro Tyr Val Cys Lys Leu Cys Asn Phe 
     290                295                300
Ala Phe Lys Thr Lys Gly Asn Leu Thr Lys His Met Lys Ser Lys Ala 
 305                310                315                320
His Met Lys Lys Cys Leu Glu Leu Gly Val Ser Met Thr Ser Val Asp 
                 325                330                335
Glu Thr Glu Thr Glu Glu Ala Glu Asn Met Glu Asp Leu His Lys Thr 
             340                345                350
Ser Glu Lys His Ser Met Ser Gly Ile Ser Thr Asp His Gln Phe Ser 
         355                360                365
Asp Ala Glu Glu Ser Asp Gly Glu Asp Gly Asp Asp Asn Asp Glu Asp 
     370                375                380
Asp Glu Asp Asp Asp Asp Phe Asp Asp Gln Gly Asp Leu Thr Pro Lys 
 385                390                395                400
Thr Arg Ser Arg Ser Thr Ser Pro Gln Pro Pro Arg Phe Ser Ser Leu 
                 405                410                415
Pro Val Asn Val Gly Ala Val Ala His Gly Val Pro Ser Asp Ser Ser 
             420                425                430
Leu Gly His Ser Ser Leu Ile Ser Tyr Leu Val Thr Leu Pro Ser Ile 
         435                440                445
Gln Val Thr Gln Leu Met Thr Pro Ser Asp Ser Cys Glu Asp Thr Gln 
     450                455                460
Met Thr Glu Tyr Gln Arg Leu Phe Gln Ser Lys Ser Thr Asp Ser Glu 
 465                470                475                480
Pro Asp Lys Asp Arg Leu Asp Ile Pro Ser Ser Met Asp Glu Glu Ala 
                 485                490                495
Met Leu Ser Ser Glu Pro Ser Ser Ser Pro Arg Asp Phe Ser Pro Ser 
             500                505                510
Ser Tyr Arg Ser Ser Pro Gly Tyr Asp Ser Ser Pro Cys Arg Asp Asn 
         515                520                525
Ser Pro Lys Arg Tyr Leu Ile Pro Lys Gly Asp Leu Ser Pro Arg Arg 
     530                535                540
His Leu Ser Pro Arg Arg Asp Leu Ser Pro Met Arg His Leu Ser Pro 
 545                550                555                560
Arg Lys Glu Ala Ala Leu Arg Arg Glu Met Ser Gln Gly Asp Ala Ser 
                 565                570                575
Pro Arg Arg His Leu Ser Pro Arg Arg Pro Leu Ser Pro Gly Lys Asp 
             580                585                590
Ile Thr Thr Arg Arg Asp Leu Ser Pro Arg Arg Glu Arg Arg Tyr Met 
         595                600                605
Thr Thr Ile Arg Ala Pro Ser Pro Arg Arg Ala Leu Tyr His Asn Pro 
     610                615                620
Pro Leu Pro Met Gly Gln Tyr Leu Gln Thr Glu Pro Ile Val Leu Gly 
 625                630                635                640
Pro Pro Asn Leu Arg Arg Gly Leu Pro Gln Val Pro Tyr Phe Ser Leu 
                 645                650                655
Tyr Gly Asp Gln Glu Gly Ala Tyr Glu His His Gly Ser Ser Leu Phe 
             660                665                670
Pro Glu Gly Pro Thr Asp Tyr Val Phe Ser His Leu Pro Leu His Ser 
         675                680                685
Gln Gln Gln Val Arg Ala Pro Ile Pro Met Val Pro Val Gly Gly Ile 
     690                695                700
Gln Met Val His Ser Leu Pro Pro Ala Ile Ser Gly Leu His Pro Pro 
 705                710                715                720
Pro Thr Leu Pro Leu Pro Thr Glu Gly Ser Glu Glu Lys Lys Gly Ala 
                 725                730                735
Pro Gly Glu Ala Leu Thr Lys Asp Pro Tyr Thr Leu Ser Arg Arg His 
             740                745                750
Glu Lys Gln Ala Pro His Val Leu Gln Ser Ser Gly Leu Pro Ser Ser 
         755                760                765
Pro Ser Ser Pro Arg Leu Leu Met Lys Gln Ser Thr Ser Glu Asp Ser 
     770                775                780
Leu Asn Ser Thr Glu Arg Glu Gln Glu Glu Asn Ile Gln Thr Cys Thr 
 785                790                795                800
Lys Ala Ile Ala Ser Leu Arg Ile Ala Thr Glu Glu Ala Ala Leu Leu 
                 805                810                815
Gly Ala Asp Gln Pro Thr Trp Val Gln Glu Ser Pro Gln Lys Pro Leu 
             820                825                830
Glu Ser Ala His Ile Ser Ile Arg His Phe Ser Gly Pro Glu Pro Gly 
         835                840                845
Gln Leu Cys Thr Ser Ala Ala His Pro Asp Leu His Asp Gly Glu Lys 
     850                855                860
Asp Thr Phe Gly Thr Ser Gln Thr Ala Val Ala His Pro Thr Phe Tyr 
 865                870                875                880
Ser Lys Gly Ser Val Asp Glu Lys Gln Val Asp Phe Gln Ser Ser Lys 
                 885                890                895
Glu Leu Ser Leu Ser Thr Glu Glu Gly Asn Glu Pro Ser Ser Glu Lys 
             900                905                910
Asn Arg Leu His 
         915



<210> 3855
<211> 9175
<212> DNA
<213> Homo sapiens
<308> X65644
<400> 3855

tatgtttag  cccatatgc  cttcctgaa  cttgccact  cccatcaag  gatagaata  60
atttcccct  cccttgaac  tggaagcaa  caagcttta  gaagcacag  tttggagac  120
ctccatgag  ctgcactgc  ttcagggga  ctagcactt  agaccttgt  taacaaaat  180
gacactggg  acacagctc  aggacaaaa  gctacctca  ggtctggag  aactgataa  240
gcatcaggt  gatggagac  ggaacaatc  gctgttatt  agatgagca  ttttggcag  300
catgaagga  agcggcaac  acaaataga  cctgagcaa  tcggaaaca  agcatcagc  360
caactgttt  gttctggga  actggcctc  cctagtgaa  tggtgcagc  agtcgcaga  420
aagcaatat  caccgcatc  tccgagtcc  tactcatgc  aacactcac  ctctttccc  480
cagcactca  tgccacagg  ggtcatgca  agcaccaag  cacatcaga  cctcgaagg  540
cctccgtgg  ttttccctg  ccctttgcc  tccgttgcc  ctgaggact  atttccttt  600
cctatacat  gccacagtg  tggttatcc  agaaaaaag  tttcaagtc  gaaccctgc  660
tatagccaa  actcccaga  aagtattga  caggcagaa  aggctcaca  gaaagagca  720
aaacccaaa  agcctggca  gtacatttg  ccttactgc  gcagagcgt  tgccaaacc  780
agtgtactg  aaaaacaca  caggtccca  actggggag  ggccatatc  atgtatacc  840
tgtggtttc  ctttcaaga  aaagagcaa  ttgtacaag  acaggaagt  acatgccca  900
gcaattaag  caggattag  acctttcac  gagtcagct  tatctaaat  ggacctaga  960
gctggtttt  ttgatgtag  agcagaaat  cattcagat  gtgaacaga  tacagacac  1020
gatgaggag  gttctttat  tgccgaggc  tctgacaaa  tgagtcctg  tccacccat  1080
ccactggac  ttgccagca  aggcggcta  catgggtca  tggaagaat  attgggagg  1140
ccaatgaag  tgccgattt  gattatccc  aaaagtggg  ttcctctcc  taatgaaag  1200
tctcagtat  ttggccctg  tatgctacc  aatccatct  taaatacta  ggctgatga  1260
tcgcacaca  tcaaacaga  acttgcact  agactgtca  agaaaaaag  acaagattc  1320
gagccatcg  tcaaccttc  gagcccgca  agtaaagga  gcactgatt  tggttactt  1380
tctcgctca  aaagtgctg  gcagcaaat  agccctccc  acacaaatg  aaagtctta  1440
gaagaaatc  tctttggaa  atactgtcg  cttagtccg  gaaatgcac  cagtgttac  1500
accacaagt  aggagcgtg  cgcaatggg  aggaagggc  taatggaac  attacctca  1560
gttaacacc  ggttagatg  caagatgtt  gaagatcct  tttcacagc  gatcccaag  1620
aagggagat  tcgacccca  tcaaacgag  atgctgaaa  ccactaagt  caacagtga  1680
tccagacaa  cccagatta  tccatcatc  atcaggaac  aaggaaaac  ttatccagc  1740
aacttccaa  gcagcaacc  ggttctctt  gaagctcct  tagactctt  accccttat  1800
agaagcaac  cagtgccaa  ttcttcagc  actaatcta  ctattcctc  ttctttgag  1860
ggaagtcac  catttgatg  aaggatgac  ggttccgac  atgtattct  tccagggac  1920
gtgggcata  cccctcagc  catgctaag  agacaagcg  catttgagc  gccttcggt  1980
caggagggc  acgtggaag  cgagcacca  ggcaggatg  tgaagggta  cagcagttc  2040
tccctgaag  aaaagaaat  gtctcctgg  gacagggtt  ggtatgact  tgatgtctg  2100
cggaaaccc  ataagaagt  ggaggactc  gaaacacca  agcaaaact  cagggacat  2160
tcctgcttg  gttctttaa  gcatggtgg  gaatatttc  tggatcccg  ggtgccatt  2220
cagggagta  caagcatgt  tggaactac  tgtgaaaac  ggaaacgcc  gaaagagaa  2280
agcgtaggg  atgaagagg  cacgcccat  atctgcagc  gcattgtaa  cactcctgt  2340
ggcatcatg  cttccgatt  tgaccccaa  ctgcagatg  aggaaggag  caggagtgg  2400
tttgccatg  ctggacacg  aaacctttc  catggtcac  cggaacgct  tgacccatg  2460
cggccccaa  tgcagcctg  aagtccatc  cttgtgtca  aggagtcac  ttcagccat  2520
gattcagac  agatgtcag  cctaggggg  aggaaacct  ctggaaatg  gatttctgt  2580
attcagcac  ccaactcac  gagccgacc  aattcattt  aaaggtctg  gtcagccga  2640
cttgtggct  gcacacagg  taaagcccc  tccccttca  agacttgtg  cagtgagat  2700
tcagaagcc  cagtgagtc  tgagtgggc  ccacctggg  atggtgcag  aagtggggg  2760
aaaccctct  catctcagc  ggtgcagca  cagtcctat  acacacagc  caggctagt  2820
cggcaacac  acatccagg  tcctgagat  cgagtgacc  aggagcctg  taaacctga  2880
aaggagaag  aagcccaga  caaagagcc  gagaagcct  tggaagaat  tcagtggcc  2940
cagagaagt  agacccttt  ccagctccc  gcggagaag  tgcctccca  aaagaagcg  3000
ctgcgactt  cagatatgg  gcactcctc  ggggagtcc  gctttgaat  cacaggcac  3060
ggcctctcc  gcagcccca  ccaagaaag  aacttgtcc  acagctcca  tttctccat  3120
tcttttgaa  gagaagaaa  cagtaagct  tctgcactt  ctaagcagg  tgagtttgg  3180
aagcattca  agtttctga  tgtccctgc  ggttcatac  cattgtctg  cccaggcca  3240
caccaccag  aagagatgc  acgctgctc  tcagagcag  tgccttgtc  tcacccagc  3300
gaagtccca  aagttcgga  caaatcatt  gattatggg  atctgtccc  tgctcctgt  3360
tcgggagca  cagcctcca  ggtatcacc  tccagggag  ggaagaaat  ctttctggt  3420
cggcaagct  ccttcagtg  ctccccaga  atctcccag  gcgaggttg  catggatca  3480
agcgtgaag  aagagcagc  ggagcacct  catgctggc  tccggtccg  gtggcacca  3540
ggcccgcct  ctgtgctgc  tcctcttca  caagaggac  cagggaagc  ggtggcggg  3600
ccttgtccc  cgctgagct  ggggccact  cacctggcc  agccacaga  catgcacat  3660
gacagtcag  aatctttga  aaatccctt  atccaacca  catcctata  gacaagcaa  3720
cacttacct  aacagccac  cttatttcc  catcaagag  caattccat  ttctccaat  3780
cagaatgcc  tgtttcagt  tcagtatcc  acagtttgt  tggttcatt  accagctca  3840
cagcctccc  ggtggcagg  acatttccc  catcccttt  ctcagcacc  tcagaagag  3900
tatggcaag  cctcttttc  gacagaaat  cattcgagc  atcccttag  gcatgtggc  3960
gagcacact  gaaagaaac  tgctgagta  gcacacacg  aagagcaga  ctacccatg  4020
tattcagga  catcagggc  acacccaaa  aaccttctt  caaagtttc  atcagacca  4080
agcagtaag  caactgaaa  gccctctga  caggttctt  aagaagatt  tgcctcggc  4140
aatgctggg  ctttgcagt  cctcccagg  acagtggtt  ctgttcgga  ccagacgca  4200
gtaccatcc  atggaagtg  catgtacac  agcatttct  agatacttg  gcagaatag  4260
cctgccatt  tcatatgca  agtcgatga  aatatgacc  aaaggacac  ggtcaccaa  4320
gcagccatg  aagggatag  attcaacat  gcccaggtg  tggggcagc  tgcgggctt  4380
gagaagtac  ccatttgga  agcacctca  actttgccc  tcggcttag  atcctccat  4440
cccttgtgt  taccttcca  ctctgacag  gtggccacc  tgggaggta  caagcgaat  4500
ctttctcca  ccagtagct  ggagctctt  atggaaacc  agcagcaga  aagggtcaa  4560
gaagaaaag  tgtacggac  gattgtgga  gagcttagt  ctgtggagc  gaccaactc  4620
gacatcaaa  aggacctct  ccgccccca  aaaccccag  tggttcgac  aggatgtgc  4680
tctgagcca  aagatggct  gcagtcagg  tcatcttcc  tctcctcgc  gtcgccctc  4740
tcatctcaa  actatcctt  tgttagccc  tcttccagg  agccattcc  gcccagcaa  4800
gagatgctt  ccggttccc  ggcaccact  ccggggcag  agtccagtg  gccttctga  4860
agcaaagaa  cttcagatg  attagatat  gatgagacg  catcggaca  gagcatgag  4920
ccacagagt  cttcattac  agcaggaga  ggtcagctg  aagaggaag  gaagggcca  4980
aagcggcct  ttggcatgc  ggtccgcat  gcctctgcc  ccagcggga  cgtggcaga  5040
tcaactctt  ttctcacgg  catggcaga  ttccagcag  ttcttcagt  ccccagtct  5100
cggacaaca  ctactgtga  ttggtgctt  ttgaattat  caaaaccca  ttatgtgca  5160
caggccacc  tcaaatcct  ggtttatgc  tcatggtgc  ttagttcct  taatccaaa  5220
ccatcagga  tgaacacca  gaccacgct  gctcttctg  ggtccaagc  aaaaatcac  5280
gcagaaatt  atactctgg  tgctatgca  aggcctgga  ccggcaagc  tacatcatc  5340
agtgcttgg  agcagttta  tcagatgaa  cctgatgcg  cctttttat  tggcagcaa  5400
ctagaaagg  aactagtgg  aaatatctt  aaggaaaga  ggaaaggag  tattcatgg  5460
gataaagat  ttggatcca  acaaactga  ccaatccga  ttaaaatat  tgaaggagg  5520
tacaaatcg  atgaagatt  tgtatatgt  agaggacgt  gccggggaa  gtacatttg  5580
gaagaatgt  ggattcgct  taagaagcc  agcatgctc  aaaaacaca  ccgtaccca  5640
actgatgtt  ggccttatg  atgcaagtt  tgtaacttt  ccttcaaaa  gaaaggaaa  5700
ctaacgaag  atatgaaat  taaagcaca  atgaaaaaa  gcctggaat  gggagtctc  5760
atgacatcg  tggatgata  agaaactga  gaagcagaa  atttggaag  tttgcacaa  5820
gcagcagag  agcatagca  gtccagcat  tcaactgat  atcagttct  cgatgctga  5880
gaatcagat  gtgaggatg  agatgataa  gatgatgat  atgaagatg  agatgactt  5940
gacgaccag  gagatttaa  accaaaaac  agatcaaga  gcaccagtc  tcagcctcc  6000
agattctcc  ccttgcctg  gaatgttgg  gccgtaccc  acggggttc  ttcagatag  6060
tccctggga  attcttcgt  gatcagcta  ttggttact  tgccaagta  tcgagttac  6120
cagcttatg  cacccagtg  ttcatgtga  gatacccag  tgacagaat  ccagaggct  6180
ttccagagc  aaagtacgg  ctcagaacc  gacaaagac  gattggaca  acctagttg  6240
atggatgag  agtgcatgc  accttcaga  ccaagctcc  ctcccaggg  cttctcacc  6300
tcaagccac  attcctctc  aggatatga  tcttcaccc  gtcgagata  ttcaccaaa  6360
aggtatctg  tacccaaag  agatttatc  cccaggaga  atttatcac  taggagaga  6420
ctgtcaccc  tgagacatc  ttcaccaac  aaggaagct  cattgagaa  agagatgtc  6480
caaagagat  tttcaccaa  aaggcattt  tctccaagg  ggccagtgt  tcctgggaa  6540
gatatcaca  caagaagag  cctctcccc  agaagagag  gaagataca  gaccacaat  6600
agagcgcca  ctcccagaa  ggctttata  cataaccca  cattgtcca  gggacagta  6660
ttgcaagca  agccaattg  attggggcc  cctaattta  gaagaggat  acctcaggt  6720
ccttacttc  gtctctatg  agaccaaga  ggtgcttat  aacatccag  ctccagcct  6780
ttccctgag  gtcctaatg  ctatgtctt  agtcatctt  cactccact  tcagcaaca  6840
gtgcgagcc  ctatcccca  ggtgcccgt  ggtgggatc  agatggttc  ctccatgcc  6900
ccagccctt  ccagtttac  tccttcacc  acattgccc  tgccaatgg  gggctttga  6960
gagaagaaa  gcgcgtcag  ggagtcctt  tccaaggac  cctatgtgc  ttctaagca  7020
catgagaag  gaggtcctc  cgctttgca  tcatctggt  cgcctagca  tccctcctc  7080
cctcggctg  tgatgaaac  gagcacttc  gaagacagc  taaacgcaa  agagcggga  7140
caggaggaa  atatacaga  ttgtacaaa  gccattgcc  ctctccgga  tgccacgga  7200
gaggcagct  tgctcgggc  agatcagcc  gcgcgggtg  aggagcccc  ccagaaccc  7260
ctgggaagt  cacatgtta  cattagaca  tttagtaga  ctgagccag  tcagccctg  7320
acctcagcc  cccaccctg  cttgcatga  ggtgaaaag  acaattttg  tacatcaca  7380
actccatta  ctcactcca  gttttacag  aagagttgt  tggatgaca  gcagttgga  7440
tttcacagc  gcaaggaat  atcttcaag  acagaggaa  gcaaagatc  ttcatcaga  7500
aagagtcag  tacattgat  tatgatgca  ggagacttt  atttccaca  tttcccatt  7560
ttttgtttt  gtttttcta  aaatggagg  aatccagtt  atagcatgc  tgtcctaag  7620
tacagtagt  tgctattat  tatactttt  ttatatcaa  agaattagg  aaattaaca  7680
gtcatcatg  gcctgacca  aacaaaatt  gaaattaac  tattgggtc  ggtactttt  7740
aaattgtac  gatgtttgt  ccttttctt  actttgctt  tattcttat  agcattttt  7800
agcagtaat  tgtacatat  ttagaattt  tgtatctgc  ttgtaataa  tgtaatttc  7860
ttccttttt  ggacacttg  atctaaatg  tgtaaagca  aacagcatc  atatatatg  7920
gaggttgca  taaaacata  ttttatatg  ttaaaactg  acagctttt  tgtacagct  7980
tgattctgt  atactaata  ttatttact  tgtttcata  attgtacat  ttttcttaa  8040
gttgtggat  gcttttcta  gtgaagcat  ggatttact  ttgcgtaac  agaacaaaa  8100
tgtacattg  aaacaagat  tttaaacta  agtatctta  tctgcactt  tgcattagt  8160
aaaaaaaga  aaaggatgt  tcagtcagt  cttaactct  gtatatttt  ttgtctctt  8220
tttgctgga  tgactataa  ttaagtgct  attgtgatt  taaaatgat  gtaccgtaa  8280
gcattaaag  aaacaatgt  ctattgtga  ttttttcaa  gctttataa  tcagttata  8340
ataatatta  aagtatttg  tcttatgtg  acatgttga  ctatatact  atctaaaaa  8400
atgggaaaa  attccaccc  atgtaaata  gtacaagtg  atcactggt  caattttat  8460
taactcagt  ggacactag  ttgccacag  cctatgcta  gtgtcttta  aaaattaag  8520
tgacaaagc  catgggact  tgtagagct  ggttatcgg  cggcccggt  gcttggcag  8580
cagtctgtc  ctgctcatg  agaagacct  ggcttagca  tctccttag  tcttgctac  8640
caggatggt  actggaact  aggctacac  gagggtcgc  cttggactc  gagggttgg  8700
tgtggaagg  ggaaaaggg  atggagacc  gctccccag  tcttcctgt  agccggttt  8760
catgggaac  gggttaaca  ctgtgttag  ggaggtcac  ttacccttt  tcatagggg  8820
agagtgtca  actcctggc  atctcaggg  gaatgggga  aagaatctt  caagggcaa  8880
gaactcgtg  gaggatgtc  gttgtatgt  atactcaca  tggcttttg  ttagtgttg  8940
aggtgggaa  agcatttgt  ggtccagaa  agtgaaaga  agggagggg  gcagcaaca  9000
gtgcacagg  acgcacatg  gtgcacgca  acatacaat  tgggttatc  ttgtgctat  9060
tagtggatt  taattctgt  aaaccaagt  tgtatattg  attacatta  ggagtgttc  9120
ttaaaaaga  aaataaata  acaattaca  gcttaaaaa  aaaaaaaaa  aaaaa  9175



<210> 3856
<211> 1833
<212> PRT
<213> Homo sapiens
<308> P31629
<400> 3856

Met Leu Lys Gly Ile Ser Ser Ser Ser Leu Lys Glu Lys Lys Leu Ser 
  1               5                  10                  15
Pro Gly Asp Arg Val Gly Tyr Asp Tyr Asp Val Cys Arg Lys Pro Tyr 
             20                  25                  30
Lys Lys Trp Glu Asp Ser Glu Thr Pro Lys Gln Asn Tyr Arg Asp Ile 
         35                  40                  45
Ser Cys Leu Ser Ser Leu Lys His Gly Gly Glu Tyr Phe Met Asp Pro 
     50                  55                  60
Val Val Pro Leu Gln Gly Val Pro Ser Met Phe Gly Thr Thr Cys Glu 
 65                  70                  75                  80
Asn Arg Lys Arg Arg Lys Glu Lys Ser Val Gly Asp Glu Glu Asp Thr 
                 85                  90                  95
Pro Met Ile Cys Ser Ser Ile Val Ser Thr Pro Val Gly Ile Met Ala 
             100                105                110
Ser Asp Tyr Asp Pro Lys Leu Gln Met Gln Glu Gly Val Arg Ser Gly 
         115                120                125
Phe Ala Met Ala Gly His Glu Asn Leu Ser His Gly His Thr Glu Arg 
     130                135                140
Phe Asp Pro Cys Arg Pro Gln Leu Gln Pro Gly Ser Pro Ser Leu Val 
 145                150                155                160
Ser Glu Glu Ser Pro Ser Ala Ile Asp Ser Asp Lys Met Ser Asp Leu 
                 165                170                175
Gly Gly Arg Lys Pro Pro Gly Asn Val Ile Ser Val Ile Gln His Thr 
             180                185                190
Asn Ser Leu Ser Arg Pro Asn Ser Phe Glu Arg Ser Glu Ser Ala Glu 
         195                200                205
Leu Val Ala Cys Thr Gln Asp Lys Ala Pro Ser Pro Ser Glu Thr Cys 
     210                215                220
Asp Ser Glu Ile Ser Glu Ala Pro Val Ser Pro Glu Trp Ala Pro Pro 
 225                230                235                240
Gly Asp Gly Ala Glu Ser Gly Gly Lys Pro Ser Pro Ser Gln Gln Val 
                 245                250                255
Gln Gln Gln Ser Tyr His Thr Gln Pro Arg Leu Val Arg Gln His Asn 
             260                265                270
Ile Gln Val Pro Glu Ile Arg Val Thr Glu Glu Pro Asp Lys Pro Glu 
         275                280                285
Lys Glu Lys Glu Ala Gln Ser Lys Glu Pro Glu Lys Pro Val Glu Glu 
     290                295                300
Phe Gln Trp Pro Gln Arg Ser Glu Thr Leu Ser Gln Leu Pro Ala Glu 
 305                310                315                320
Lys Leu Pro Pro Lys Lys Lys Arg Leu Arg Leu Ala Asp Met Glu His 
                 325                330                335
Ser Ser Gly Glu Ser Ser Phe Glu Ser Thr Gly Thr Gly Leu Ser Arg 
             340                345                350
Ser Pro Ser Gln Glu Ser Asn Leu Ser His Ser Ser Ser Phe Ser Met 
         355                360                365
Ser Phe Glu Arg Glu Glu Thr Ser Lys Leu Ser Ala Leu Pro Lys Gln 
     370                375                380
Asp Glu Phe Gly Lys His Ser Glu Phe Leu Thr Val Pro Ala Gly Ser 
 385                390                395                400
Tyr Ser Leu Ser Val Pro Gly His His His Gln Lys Glu Met Arg Arg 
                 405                410                415
Cys Ser Ser Glu Gln Met Pro Cys Pro His Pro Ala Glu Val Pro Glu 
             420                425                430
Val Arg Ser Lys Ser Phe Asp Tyr Gly Asn Leu Ser His Ala Pro Val 
         435                440                445
Ser Gly Ala Ala Ala Ser Thr Val Ser Pro Ser Arg Glu Arg Lys Lys 
     450                455                460
Cys Phe Leu Val Arg Gln Ala Ser Phe Ser Gly Ser Pro Glu Ile Ser 
 465                470                475                480
Gln Gly Glu Val Gly Met Asp Gln Ser Val Lys Gln Glu Gln Leu Glu 
                 485                490                495
His Leu His Ala Gly Leu Arg Ser Gly Trp His His Gly Pro Pro Ala 
             500                505                510
Val Leu Pro Pro Leu Gln Gln Glu Asp Pro Gly Lys Gln Val Ala Gly 
         515                520                525
Pro Cys Pro Pro Leu Ser Ser Gly Pro Leu His Leu Ala Gln Pro Gln 
     530                535                540
Ile Met His Met Asp Ser Gln Glu Ser Leu Arg Asn Pro Leu Ile Gln 
 545                550                555                560
Pro Thr Ser Tyr Met Thr Ser Lys His Leu Pro Glu Gln Pro His Leu 
                 565                570                575
Phe Pro His Gln Glu Thr Ile Pro Phe Ser Pro Ile Gln Asn Ala Leu 
             580                585                590
Phe Gln Phe Gln Tyr Pro Thr Val Cys Met Val His Leu Pro Ala Gln 
         595                600                605
Gln Pro Pro Trp Trp Gln Ala His Phe Pro His Pro Phe Ala Gln His 
     610                615                620
Pro Gln Lys Ser Tyr Gly Lys Pro Ser Phe Gln Thr Glu Ile His Ser 
 625                630                635                640
Ser Tyr Pro Leu Glu His Val Ala Glu His Thr Gly Lys Lys Pro Ala 
                 645                650                655
Glu Tyr Ala His Thr Lys Glu Gln Thr Tyr Pro Cys Tyr Ser Gly Ala 
             660                665                670
Ser Gly Leu His Pro Lys Asn Leu Leu Pro Lys Phe Pro Ser Asp Gln 
         675                680                685
Ser Ser Lys Ser Thr Glu Thr Pro Ser Glu Gln Val Leu Gln Glu Asp 
     690                695                700
Phe Ala Ser Ala Asn Ala Gly Ser Leu Gln Ser Leu Pro Gly Thr Val 
 705                710                715                720
Val Pro Val Arg Ile Gln Thr His Val Pro Ser Tyr Gly Ser Val Met 
                 725                730                735
Tyr Thr Ser Ile Ser Gln Ile Leu Gly Gln Asn Ser Pro Ala Ile Val 
             740                745                750
Ile Cys Lys Val Asp Glu Asn Met Thr Gln Arg Thr Leu Val Thr Asn 
         755                760                765
Ala Ala Met Gln Gly Ile Gly Phe Asn Ile Ala Gln Val Leu Gly Gln 
     770                775                780
His Ala Gly Leu Glu Lys Tyr Pro Ile Trp Lys Ala Pro Gln Thr Leu 
 785                790                795                800
Pro Leu Gly Leu Glu Ser Ser Ile Pro Leu Cys Leu Pro Ser Thr Ser 
                 805                810                815
Asp Ser Val Ala Thr Leu Gly Gly Ser Lys Arg Met Leu Ser Pro Ala 
             820                825                830
Ser Ser Leu Glu Leu Phe Met Glu Thr Lys Gln Gln Lys Arg Val Lys 
         835                840                845
Glu Glu Lys Met Tyr Gly Gln Ile Val Glu Glu Leu Ser Ala Val Glu 
     850                855                860
Leu Thr Asn Ser Asp Ile Lys Lys Asp Leu Ser Arg Pro Gln Lys Pro 
 865                870                875                880
Gln Leu Val Arg Gln Gly Cys Ala Ser Glu Pro Lys Asp Gly Leu Gln 
                 885                890                895
Ser Gly Ser Ser Ser Phe Ser Ser Leu Ser Pro Ser Ser Ser Gln Asp 
             900                905                910
Tyr Pro Ser Val Ser Pro Ser Ser Arg Glu Pro Phe Pro Pro Ser Lys 
         915                920                925
Glu Met Leu Ser Gly Ser Arg Ala Pro Leu Pro Gly Gln Lys Ser Ser 
     930                935                940
Gly Pro Ser Glu Ser Lys Glu Ser Ser Asp Glu Leu Asp Ile Asp Glu 
 945                950                955                960
Thr Ala Ser Asp Met Ser Met Ser Pro Gln Ser Ser Ser Leu Pro Ala 
                 965                970                975
Gly Asp Gly Gln Leu Glu Glu Glu Gly Lys Gly His Lys Arg Pro Val 
             980                985                990
Gly Met Leu Val Arg Met Ala Ser Ala Pro Ser Gly Asn Val Ala Asp 
         995                1000                1005
Ser Thr Leu Leu Leu Thr Asp Met Ala Asp Phe Gln Gln Ile Leu Gln 
     1010                1015                1020
Phe Pro Ser Leu Arg Thr Thr Thr Thr Val Ser Trp Cys Phe Leu Asn 
 1025                1030                1035                1040
Tyr Thr Lys Pro Asn Tyr Val Gln Gln Ala Thr Phe Lys Ser Ser Val 
                 1045                1050                1055
Tyr Ala Ser Trp Cys Ile Ser Ser Cys Asn Pro Asn Pro Ser Gly Leu 
             1060                1065                1070
Asn Thr Lys Thr Thr Leu Ala Leu Leu Arg Ser Lys Gln Lys Ile Thr 
         1075                1080                1085
Ala Glu Ile Tyr Thr Leu Ala Ala Met His Arg Pro Gly Thr Gly Lys 
     1090                1095                1100
Leu Thr Ser Ser Ser Ala Trp Lys Gln Phe Thr Gln Met Lys Pro Asp 
 1105                1110                1115                1120
Ala Ser Phe Leu Phe Gly Ser Lys Leu Glu Arg Lys Leu Val Gly Asn 
                 1125                1130                1135
Ile Leu Lys Glu Arg Gly Lys Gly Asp Ile His Gly Asp Lys Asp Ile 
             1140                1145                1150
Gly Ser Lys Gln Thr Glu Pro Ile Arg Ile Lys Ile Phe Glu Gly Gly 
         1155                1160                1165
Tyr Lys Ser Asn Glu Asp Tyr Val Tyr Val Arg Gly Arg Gly Arg Gly 
     1170                1175                1180
Lys Tyr Ile Cys Glu Glu Cys Gly Ile Arg Cys Lys Lys Pro Ser Met 
 1185                1190                1195                1200
Leu Lys Lys His Ile Arg Thr His Thr Asp Val Arg Pro Tyr Val Cys 
                 1205                1210                1215
Lys Leu Cys Asn Phe Ala Phe Lys Thr Lys Gly Asn Leu Thr Lys His 
             1220                1225                1230
Met Lys Ser Lys Ala His Met Lys Lys Cys Leu Glu Leu Gly Val Ser 
         1235                1240                1245
Met Thr Ser Val Asp Asp Thr Glu Thr Glu Glu Ala Glu Asn Leu Glu 
     1250                1255                1260
Asp Leu His Lys Ala Ala Glu Lys His Ser Met Ser Ser Ile Ser Thr 
 1265                1270                1275                1280
Asp His Gln Phe Ser Asp Ala Glu Glu Ser Asp Gly Glu Asp Gly Asp 
                 1285                1290                1295
Asp Asn Asp Asp Asp Asp Glu Asp Glu Asp Asp Phe Asp Asp Gln Gly 
             1300                1305                1310
Asp Leu Thr Pro Lys Thr Arg Ser Arg Ser Thr Ser Pro Gln Pro Pro 
         1315                1320                1325
Arg Phe Ser Ser Leu Pro Val Asn Val Gly Ala Val Pro His Gly Val 
     1330                1335                1340
Pro Ser Asp Ser Ser Leu Gly His Ser Ser Leu Ile Ser Tyr Leu Val 
 1345                1350                1355                1360
Thr Leu Pro Ser Ile Arg Val Thr Gln Leu Met Thr Pro Ser Asp Ser 
                 1365                1370                1375
Cys Glu Asp Thr Gln Met Thr Glu Tyr Gln Arg Leu Phe Gln Ser Lys 
             1380                1385                1390
Ser Thr Asp Ser Glu Pro Asp Lys Asp Arg Leu Asp Ile Pro Ser Cys 
         1395                1400                1405
Met Asp Glu Glu Cys Met Leu Pro Ser Glu Pro Ser Ser Ser Pro Arg 
     1410                1415                1420
Asp Phe Ser Pro Ser Ser His His Ser Ser Pro Gly Tyr Asp Ser Ser 
 1425                1430                1435                1440
Pro Cys Arg Asp Asn Ser Pro Lys Arg Tyr Leu Ile Pro Lys Gly Asp 
                 1445                1450                1455
Leu Ser Pro Arg Arg His Leu Ser Pro Arg Arg Asp Leu Ser Pro Met 
             1460                1465                1470
Arg His Leu Ser Pro Arg Lys Glu Ala Ala Leu Arg Arg Glu Met Ser 
         1475                1480                1485
Gln Arg Asp Val Ser Pro Arg Arg His Leu Ser Pro Arg Arg Pro Val 
     1490                1495                1500
Ser Pro Gly Lys Asp Ile Thr Ala Arg Arg Asp Leu Ser Pro Arg Arg 
 1505                1510                1515                1520
Glu Arg Arg Tyr Met Thr Thr Ile Arg Ala Pro Ser Pro Arg Arg Ala 
                 1525                1530                1535
Leu Tyr His Asn Pro Pro Leu Ser Met Gly Gln Tyr Leu Gln Ala Glu 
             1540                1545                1550
Pro Ile Val Leu Gly Pro Pro Asn Leu Arg Arg Gly Leu Pro Gln Val 
         1555                1560                1565
Pro Tyr Phe Ser Leu Tyr Gly Asp Gln Glu Gly Ala Tyr Glu His Pro 
     1570                1575                1580
Gly Ser Ser Leu Phe Pro Glu Gly Pro Asn Asp Tyr Val Phe Ser His 
 1585                1590                1595                1600
Leu Pro Leu His Ser Gln Gln Gln Val Arg Ala Pro Ile Pro Met Val 
                 1605                1610                1615
Pro Val Gly Gly Ile Gln Met Val His Ser Met Pro Pro Ala Leu Ser 
             1620                1625                1630
Ser Leu His Pro Ser Pro Thr Leu Pro Leu Pro Met Glu Gly Phe Glu 
         1635                1640                1645
Glu Lys Lys Gly Ala Ser Gly Glu Ser Phe Ser Lys Asp Pro Tyr Val 
     1650                1655                1660
Leu Ser Lys Gln His Glu Lys Arg Gly Pro His Ala Leu Gln Ser Ser 
 1665                1670                1675                1680
Gly Pro Pro Ser Thr Pro Ser Ser Pro Arg Leu Leu Met Lys Gln Ser 
                 1685                1690                1695
Thr Ser Glu Asp Ser Leu Asn Ala Thr Glu Arg Glu Gln Glu Glu Asn 
             1700                1705                1710
Ile Gln Thr Cys Thr Lys Ala Ile Ala Ser Leu Arg Ile Ala Thr Glu 
         1715                1720                1725
Glu Ala Ala Leu Leu Gly Pro Asp Gln Pro Ala Arg Val Gln Glu Pro 
     1730                1735                1740
His Gln Asn Pro Leu Gly Ser Ala His Val Ser Ile Arg His Phe Ser 
 1745                1750                1755                1760
Arg Pro Glu Pro Gly Gln Pro Cys Thr Ser Ala Thr His Pro Asp Leu 
                 1765                1770                1775
His Asp Gly Glu Lys Asp Asn Phe Gly Thr Ser Gln Thr Pro Leu Ala 
             1780                1785                1790
His Ser Thr Phe Tyr Ser Lys Ser Cys Val Asp Asp Lys Gln Leu Asp 
         1795                1800                1805
Phe His Ser Ser Lys Glu Leu Ser Ser Ser Thr Glu Glu Ser Lys Asp 
     1810                1815                1820
Pro Ser Ser Glu Lys Ser Gln Leu His 
 1825                1830



<210> 3857
<211> 3774
<212> DNA
<213> Rattus norvegicus
<308> M65251
<400> 3857

gaattccgg  tgccagcgg  cctttccct  ccaacaggg  gatactttc  ggttccagg  60
cgccgccgc  acggaagtt  agtgggccc  cagaaagca  agagtcctc  gatgagctg  120
acatcgatg  gacctcgtc  gacatgagc  tgagccccc  gagctcttc  ctgcccaca  180
gaggcagtc  gcaggaaga  gaagggaag  cccgcaagc  gccagtcag  atgctagtc  240
acatggcct  tggtccggg  ggaaatgtg  caaattcca  tcttctttt  acagacgtg  300
cagatttcc  gcagatcct  cagttcccc  gtctgcgga  aacaactac  gtgagttgg  360
gcttcttaa  ttatacaaa  cccaatttt  tgcaacagg  caccttcaa  tcctccgtt  420
atgcttcat  gtgcattag  tcctgtaac  caaacccat  aggattgaa  accaagacc  480
cgctggccc  cctgagatc  aaacaaaaa  ttaccgccg  aatttacac  ctggctgct  540
tgcacaggc  cggaactgg  aagctcaca  catccagtg  ctggaagca  tttgcacag  600
tgaaacctg  tgcaccctt  ttgtttggc  acaaactag  aaggaaatt  gggggaaat  660
tcttaaagg  aagagggaa  ggagagatt  acggagata  agatcttgg  tccaaacaa  720
ccgagccaa  ccgaattaa  atctttgaa  gggggtaca  atccaatga  gattatgtg  780
atgtcagag  acgtggacg  ggaaagtac  tttgtgaag  gtgtggaat  cgctgtaag  840
agccaagca  gctgaaaaa  catatacgc  ctcatactg  tgttcggcc  tatgtatgc  900
agttatgta  ttttgcctt  aagacgaaa  gaaacctaa  gaaacacat  aaatctaag  960
cccacatga  aaagtgtct  gagctgggc  tctcgatga  atcagtaga  gagacagaa  1020
cagaagaag  agaaaatat  gaagatttg  acaaaacat  tgagaagca  agcatgtcc  1080
gcatttcaa  tgaccacca  ttctcagat  ctgaggaat  tgacggaga  gatggagac  1140
ataatgatg  agatgatga  gacgatgat  actttgatg  ccaaggaga  ttgacaccc  1200
aaacaaggt  aagaagcac  agtcctcag  ctcctcggt  ctcctcctt  cctgtcaat  1260
ttggcgctg  agcccacgg  gtcccctca  atagctctc  gggacattc  tcattgatc  1320
gctatttgg  tactctacc  agtattcag  tcactcagc  catgacacc  agtgactct  1380
gtgaagaca  ccagatgac  gaatatcag  ggctgttcc  gagcaaaag  acagactcc  1440
aacccgaca  agacaggtt  gacatccca  gctccatgg  cgaagaggc  atgttgtct  1500
cagagccaa  ctcctcccc  agggacttc  ccccctcaa  ctaccggtc  tcaccagga  1560
atgattctt  accctgtcg  gataattcg  caaagaggt  tctgatacc  aaaggagat  1620
tgtcaccca  aagacattt  tcacctaga  gagatctat  acccatgag  catctgtca  1680
caagaaaag  agctgcatt  aggagagag  tgtcccaag  ggatgcttc  ccaaggagg  1740
atttgtccc  acggagacc  ttgtctcct  gaaaagaca  tacaacaag  agggacctc  1800
ctcccagaa  agagagaag  tatatgact  ccattagag  accatctcc  agaagggct  1860
tataccata  cccaccatt  ccaatgggg  agtatctgc  aacagagcc  attgtattg  1920
ggcctccta  tctaagaag  ggattacct  aggttcctt  cttcagtct  tatggagac  1980
aagaaggtg  ttatgaaca  cacggctcc  gccttttcc  tgagggtcc  actgactat  2040
tcttcagtc  tcttcccct  cattctcag  agcaagtgc  agctcctat  cccatggtg  2100
cagttggtg  gatccaaat  gttcactcc  tgccgccag  catttccgg  ttacatcct  2160
cacccacat  gcctctgcc  acagagggc  ctgaggaga  gaaaggagc  cccggggag  2220
ccctcacca  ggatcccta  accctttcc  ggcggcatg  gaaacaagc  cctcacgtt  2280
tgcagtcat  tggtctacc  agttctccc  cctccccac  gctattgat  aaacagagt  2340
cttcagaag  cagcctaaa  tccacagag  gagaacagg  ggaaaacat  cagacttgt  2400
caaaagcca  cgcctcact  cggattgca  cagaagagg  agctctgct  ggggctgat  2460
agcccacat  ggtgcagga  tccccgcag  aacccttgg  gagtgcaca  atcagcatt  2520
gacacttta  cgggcctga  ccaggtcag  tctgtacct  agccgccca  cctgactta  2580
acgatggtg  aaaggacac  tttggtaca  cacagactg  agtagccca  cccacgttt  2640
acagcaagg  cagtgtgga  gagaagcag  tggactttc  gagcagcaa  gaattatct  2700
taagcacag  ggaaggcaa  gagccctca  cggaaaaga  tcgactcca  tgatctgca  2760
tgcatggac  cattcattt  cacatttcc  cctcccccc  tttgttttt  tttttctag  2820
gatagaaat  aacgagttg  tagcatgcc  gtcctaagt  acagtagtt  gctattata  2880
atacttttg  tattttgaa  acaattagg  aaattaacc  agtcgatct  gagcctgac  2940
aaaacaaaa  ttgaaatta  cctattggg  ctggtaact  tgaaaaaaa  tgtacagat  3000
tttgtgcct  ttctttact  tgtttatat  cttataagc  tttttttag  ggtaatttg  3060
atatatttt  gaatttgtg  atctgcttt  taataaatg  aatctcttt  ctcttttga  3120
acttggatc  taacgacgt  aagcaaagc  gcatctata  atattgtga  gttgcacta  3180
aacatattt  tatatgata  aactgaaca  cttttatgt  cagctctca  tctgtaata  3240
taatattta  tttgtttca  aaactgtac  tttttttct  aatgttgtg  attgctttt  3300
tatgtgaag  atggttccc  gttgcgtaa  tagaacaga  atgtccatg  aagcaanat  3360
tttaaacta  natatctta  tctgcactt  tgcataagt  acaaaaaaa  ataaagaag  3420
atcagtcgg  tcttaacct  taaattctt  ttgtctctt  tttgccgga  tgacaataa  3480
ttaagagct  attgtgatt  ttaaatgga  agtacgtaa  gcattaaag  aaacaatgt  3540
ctattgtga  tttttttca  agctttata  atcagttat  aataatatt  aagtatttg  3600
tcttatgtg  acatgttga  ctatatact  accttaaaa  atatgggaa  aacattccg  3660
ccccatgta  atatgtaca  gtgcatcac  ggtacagtt  tgtgttact  ggttggaca  3720
gaggttgcc  cagacctat  ctagagtgt  tttaaaatt  aagtgagaa  gcac  3774



<210> 3858
<211> 916
<212> PRT
<213> Rattus norvegicus
<308> Q00900
<400> 3858

Ile Pro Ala Ala Ser Gly Pro Phe Pro Pro Asn Arg Glu Ile Leu Ser 
  1               5                  10                  15
Gly Ser Arg Ala Pro Pro Arg Arg Lys Phe Ser Gly Pro Ser Glu Ser 
             20                  25                  30
Arg Glu Ser Ser Asp Glu Leu Asp Ile Asp Glu Thr Ser Ser Asp Met 
         35                  40                  45
Ser Met Ser Pro Gln Ser Ser Ser Leu Pro Thr Gly Gly Ser Gln Gln 
     50                  55                  60
Glu Asp Glu Gly Lys Ala Arg Lys Leu Pro Val Ser Met Leu Val His 
 65                  70                  75                  80
Met Ala Ser Gly Pro Gly Gly Asn Val Ala Asn Ser Thr Leu Leu Phe 
                 85                  90                  95
Thr Asp Val Ala Asp Phe Gln Gln Ile Leu Gln Phe Pro Ser Leu Arg 
             100                105                110
Thr Thr Thr Thr Val Ser Trp Cys Phe Leu Asn Tyr Thr Lys Pro Asn 
         115                120                125
Phe Val Gln Gln Ala Thr Phe Lys Ser Ser Val Tyr Ala Ser Trp Cys 
     130                135                140
Ile Ser Ser Cys Asn Pro Asn Pro Ser Gly Leu Asn Thr Lys Thr Thr 
 145                150                155                160
Leu Ala Leu Leu Arg Ser Lys Gln Lys Ile Thr Ala Glu Ile Tyr Thr 
                 165                170                175
Leu Ala Ala Met His Arg Pro Gly Thr Gly Lys Leu Thr Ser Ser Ser 
             180                185                190
Ala Trp Lys Gln Phe Ala Gln Met Lys Pro Asp Ala Pro Phe Leu Phe 
         195                200                205
Gly Asn Lys Leu Glu Arg Lys Leu Gly Gly Asn Val Leu Lys Glu Arg 
     210                215                220
Gly Lys Gly Glu Ile His Gly Asp Lys Asp Leu Gly Ser Lys Gln Thr 
 225                230                235                240
Glu Pro Ile Arg Ile Lys Ile Phe Glu Gly Gly Tyr Lys Ser Asn Glu 
                 245                250                255
Asp Tyr Val Tyr Val Arg Gly Arg Gly Arg Gly Lys Tyr Ile Cys Glu 
             260                265                270
Glu Cys Gly Ile Arg Cys Lys Lys Pro Ser Met Leu Lys Lys His Ile 
         275                280                285
Arg Thr His Thr Asp Val Arg Pro Tyr Val Cys Lys Leu Cys Asn Phe 
     290                295                300
Ala Phe Lys Thr Lys Gly Asn Leu Thr Lys His Met Lys Ser Lys Ala 
 305                310                315                320
His Met Lys Lys Cys Leu Glu Leu Gly Val Ser Met Thr Ser Val Asp 
                 325                330                335
Glu Thr Glu Thr Glu Glu Ala Glu Asn Met Glu Asp Leu His Lys Thr 
             340                345                350
Ser Glu Lys His Ser Met Ser Gly Ile Ser Thr Asp His Gln Phe Ser 
         355                360                365
Asp Ala Glu Glu Ser Asp Gly Glu Asp Gly Asp Asp Asn Asp Glu Asp 
     370                375                380
Asp Glu Asp Asp Asp Asp Phe Asp Asp Gln Gly Asp Leu Thr Pro Lys 
 385                390                395                400
Thr Arg Ser Arg Ser Thr Ser Pro Gln Pro Pro Arg Phe Ser Ser Leu 
                 405                410                415
Pro Val Asn Val Gly Ala Val Ala His Gly Val Pro Ser Asp Ser Ser 
             420                425                430
Leu Gly His Ser Ser Leu Ile Ser Tyr Leu Val Thr Leu Pro Ser Ile 
         435                440                445
Gln Val Thr Gln Leu Met Thr Pro Ser Asp Ser Cys Glu Asp Thr Gln 
     450                455                460
Met Thr Glu Tyr Gln Arg Leu Phe Gln Ser Lys Ser Thr Asp Ser Glu 
 465                470                475                480
Pro Asp Lys Asp Arg Leu Asp Ile Pro Ser Ser Met Asp Glu Glu Ala 
                 485                490                495
Met Leu Ser Ser Glu Pro Ser Ser Ser Pro Arg Asp Phe Ser Pro Ser 
             500                505                510
Ser Tyr Arg Ser Ser Pro Gly Tyr Asp Ser Ser Pro Cys Arg Asp Asn 
         515                520                525
Ser Pro Lys Arg Tyr Leu Ile Pro Lys Gly Asp Leu Ser Pro Arg Arg 
     530                535                540
His Leu Ser Pro Arg Arg Asp Leu Ser Pro Met Arg His Leu Ser Pro 
 545                550                555                560
Arg Lys Glu Ala Ala Leu Arg Arg Glu Met Ser Gln Gly Asp Ala Ser 
                 565                570                575
Pro Arg Arg His Leu Ser Pro Arg Arg Pro Leu Ser Pro Gly Lys Asp 
             580                585                590
Ile Thr Thr Arg Arg Asp Leu Ser Pro Arg Arg Glu Arg Arg Tyr Met 
         595                600                605
Thr Thr Ile Arg Ala Pro Ser Pro Arg Arg Ala Leu Tyr His Asn Pro 
     610                615                620
Pro Leu Pro Met Gly Gln Tyr Leu Gln Thr Glu Pro Ile Val Leu Gly 
 625                630                635                640
Pro Pro Asn Leu Arg Arg Gly Leu Pro Gln Val Pro Tyr Phe Ser Leu 
                 645                650                655
Tyr Gly Asp Gln Glu Gly Ala Tyr Glu His His Gly Ser Ser Leu Phe 
             660                665                670
Pro Glu Gly Pro Thr Asp Tyr Val Phe Ser His Leu Pro Leu His Ser 
         675                680                685
Gln Gln Gln Val Arg Ala Pro Ile Pro Met Val Pro Val Gly Gly Ile 
     690                695                700
Gln Met Val His Ser Leu Pro Pro Ala Ile Ser Gly Leu His Pro Pro 
 705                710                715                720
Pro Thr Leu Pro Leu Pro Thr Glu Gly Ser Glu Glu Lys Lys Gly Ala 
                 725                730                735
Pro Gly Glu Ala Leu Thr Lys Asp Pro Tyr Thr Leu Ser Arg Arg His 
             740                745                750
Glu Lys Gln Ala Pro His Val Leu Gln Ser Ser Gly Leu Pro Ser Ser 
         755                760                765
Pro Ser Ser Pro Arg Leu Leu Met Lys Gln Ser Thr Ser Glu Asp Ser 
     770                775                780
Leu Asn Ser Thr Glu Arg Glu Gln Glu Glu Asn Ile Gln Thr Cys Thr 
 785                790                795                800
Lys Ala Ile Ala Ser Leu Arg Ile Ala Thr Glu Glu Ala Ala Leu Leu 
                 805                810                815
Gly Ala Asp Gln Pro Thr Trp Val Gln Glu Ser Pro Gln Lys Pro Leu 
             820                825                830
Glu Ser Ala His Ile Ser Ile Arg His Phe Ser Gly Pro Glu Pro Gly 
         835                840                845
Gln Leu Cys Thr Ser Ala Ala His Pro Asp Leu His Asp Gly Glu Lys 
     850                855                860
Asp Thr Phe Gly Thr Ser Gln Thr Ala Val Ala His Pro Thr Phe Tyr 
 865                870                875                880
Ser Lys Gly Ser Val Asp Glu Lys Gln Val Asp Phe Gln Ser Ser Lys 
                 885                890                895
Glu Leu Ser Leu Ser Thr Glu Glu Gly Asn Glu Pro Ser Ser Glu Lys 
             900                905                910
Asn Arg Leu His 
         915



<210> 3859
<211> 9175
<212> DNA
<213> Homo sapiens
<308> X65644
<400> 3859

tatgtttag  cccatatgc  cttcctgaa  cttgccact  cccatcaag  gatagaata  60
atttcccct  cccttgaac  tggaagcaa  caagcttta  gaagcacag  tttggagac  120
ctccatgag  ctgcactgc  ttcagggga  ctagcactt  agaccttgt  taacaaaat  180
gacactggg  acacagctc  aggacaaaa  gctacctca  ggtctggag  aactgataa  240
gcatcaggt  gatggagac  ggaacaatc  gctgttatt  agatgagca  ttttggcag  300
catgaagga  agcggcaac  acaaataga  cctgagcaa  tcggaaaca  agcatcagc  360
caactgttt  gttctggga  actggcctc  cctagtgaa  tggtgcagc  agtcgcaga  420
aagcaatat  caccgcatc  tccgagtcc  tactcatgc  aacactcac  ctctttccc  480
cagcactca  tgccacagg  ggtcatgca  agcaccaag  cacatcaga  cctcgaagg  540
cctccgtgg  ttttccctg  ccctttgcc  tccgttgcc  ctgaggact  atttccttt  600
cctatacat  gccacagtg  tggttatcc  agaaaaaag  tttcaagtc  gaaccctgc  660
tatagccaa  actcccaga  aagtattga  caggcagaa  aggctcaca  gaaagagca  720
aaacccaaa  agcctggca  gtacatttg  ccttactgc  gcagagcgt  tgccaaacc  780
agtgtactg  aaaaacaca  caggtccca  actggggag  ggccatatc  atgtatacc  840
tgtggtttc  ctttcaaga  aaagagcaa  ttgtacaag  acaggaagt  acatgccca  900
gcaattaag  caggattag  acctttcac  gagtcagct  tatctaaat  ggacctaga  960
gctggtttt  ttgatgtag  agcagaaat  cattcagat  gtgaacaga  tacagacac  1020
gatgaggag  gttctttat  tgccgaggc  tctgacaaa  tgagtcctg  tccacccat  1080
ccactggac  ttgccagca  aggcggcta  catgggtca  tggaagaat  attgggagg  1140
ccaatgaag  tgccgattt  gattatccc  aaaagtggg  ttcctctcc  taatgaaag  1200
tctcagtat  ttggccctg  tatgctacc  aatccatct  taaatacta  ggctgatga  1260
tcgcacaca  tcaaacaga  acttgcact  agactgtca  agaaaaaag  acaagattc  1320
gagccatcg  tcaaccttc  gagcccgca  agtaaagga  gcactgatt  tggttactt  1380
tctcgctca  aaagtgctg  gcagcaaat  agccctccc  acacaaatg  aaagtctta  1440
gaagaaatc  tctttggaa  atactgtcg  cttagtccg  gaaatgcac  cagtgttac  1500
accacaagt  aggagcgtg  cgcaatggg  aggaagggc  taatggaac  attacctca  1560
gttaacacc  ggttagatg  caagatgtt  gaagatcct  tttcacagc  gatcccaag  1620
aagggagat  tcgacccca  tcaaacgag  atgctgaaa  ccactaagt  caacagtga  1680
tccagacaa  cccagatta  tccatcatc  atcaggaac  aaggaaaac  ttatccagc  1740
aacttccaa  gcagcaacc  ggttctctt  gaagctcct  tagactctt  accccttat  1800
agaagcaac  cagtgccaa  ttcttcagc  actaatcta  ctattcctc  ttctttgag  1860
ggaagtcac  catttgatg  aaggatgac  ggttccgac  atgtattct  tccagggac  1920
gtgggcata  cccctcagc  catgctaag  agacaagcg  catttgagc  gccttcggt  1980
caggagggc  acgtggaag  cgagcacca  ggcaggatg  tgaagggta  cagcagttc  2040
tccctgaag  aaaagaaat  gtctcctgg  gacagggtt  ggtatgact  tgatgtctg  2100
cggaaaccc  ataagaagt  ggaggactc  gaaacacca  agcaaaact  cagggacat  2160
tcctgcttg  gttctttaa  gcatggtgg  gaatatttc  tggatcccg  ggtgccatt  2220
cagggagta  caagcatgt  tggaactac  tgtgaaaac  ggaaacgcc  gaaagagaa  2280
agcgtaggg  atgaagagg  cacgcccat  atctgcagc  gcattgtaa  cactcctgt  2340
ggcatcatg  cttccgatt  tgaccccaa  ctgcagatg  aggaaggag  caggagtgg  2400
tttgccatg  ctggacacg  aaacctttc  catggtcac  cggaacgct  tgacccatg  2460
cggccccaa  tgcagcctg  aagtccatc  cttgtgtca  aggagtcac  ttcagccat  2520
gattcagac  agatgtcag  cctaggggg  aggaaacct  ctggaaatg  gatttctgt  2580
attcagcac  ccaactcac  gagccgacc  aattcattt  aaaggtctg  gtcagccga  2640
cttgtggct  gcacacagg  taaagcccc  tccccttca  agacttgtg  cagtgagat  2700
tcagaagcc  cagtgagtc  tgagtgggc  ccacctggg  atggtgcag  aagtggggg  2760
aaaccctct  catctcagc  ggtgcagca  cagtcctat  acacacagc  caggctagt  2820
cggcaacac  acatccagg  tcctgagat  cgagtgacc  aggagcctg  taaacctga  2880
aaggagaag  aagcccaga  caaagagcc  gagaagcct  tggaagaat  tcagtggcc  2940
cagagaagt  agacccttt  ccagctccc  gcggagaag  tgcctccca  aaagaagcg  3000
ctgcgactt  cagatatgg  gcactcctc  ggggagtcc  gctttgaat  cacaggcac  3060
ggcctctcc  gcagcccca  ccaagaaag  aacttgtcc  acagctcca  tttctccat  3120
tcttttgaa  gagaagaaa  cagtaagct  tctgcactt  ctaagcagg  tgagtttgg  3180
aagcattca  agtttctga  tgtccctgc  ggttcatac  cattgtctg  cccaggcca  3240
caccaccag  aagagatgc  acgctgctc  tcagagcag  tgccttgtc  tcacccagc  3300
gaagtccca  aagttcgga  caaatcatt  gattatggg  atctgtccc  tgctcctgt  3360
tcgggagca  cagcctcca  ggtatcacc  tccagggag  ggaagaaat  ctttctggt  3420
cggcaagct  ccttcagtg  ctccccaga  atctcccag  gcgaggttg  catggatca  3480
agcgtgaag  aagagcagc  ggagcacct  catgctggc  tccggtccg  gtggcacca  3540
ggcccgcct  ctgtgctgc  tcctcttca  caagaggac  cagggaagc  ggtggcggg  3600
ccttgtccc  cgctgagct  ggggccact  cacctggcc  agccacaga  catgcacat  3660
gacagtcag  aatctttga  aaatccctt  atccaacca  catcctata  gacaagcaa  3720
cacttacct  aacagccac  cttatttcc  catcaagag  caattccat  ttctccaat  3780
cagaatgcc  tgtttcagt  tcagtatcc  acagtttgt  tggttcatt  accagctca  3840
cagcctccc  ggtggcagg  acatttccc  catcccttt  ctcagcacc  tcagaagag  3900
tatggcaag  cctcttttc  gacagaaat  cattcgagc  atcccttag  gcatgtggc  3960
gagcacact  gaaagaaac  tgctgagta  gcacacacg  aagagcaga  ctacccatg  4020
tattcagga  catcagggc  acacccaaa  aaccttctt  caaagtttc  atcagacca  4080
agcagtaag  caactgaaa  gccctctga  caggttctt  aagaagatt  tgcctcggc  4140
aatgctggg  ctttgcagt  cctcccagg  acagtggtt  ctgttcgga  ccagacgca  4200
gtaccatcc  atggaagtg  catgtacac  agcatttct  agatacttg  gcagaatag  4260
cctgccatt  tcatatgca  agtcgatga  aatatgacc  aaaggacac  ggtcaccaa  4320
gcagccatg  aagggatag  attcaacat  gcccaggtg  tggggcagc  tgcgggctt  4380
gagaagtac  ccatttgga  agcacctca  actttgccc  tcggcttag  atcctccat  4440
cccttgtgt  taccttcca  ctctgacag  gtggccacc  tgggaggta  caagcgaat  4500
ctttctcca  ccagtagct  ggagctctt  atggaaacc  agcagcaga  aagggtcaa  4560
gaagaaaag  tgtacggac  gattgtgga  gagcttagt  ctgtggagc  gaccaactc  4620
gacatcaaa  aggacctct  ccgccccca  aaaccccag  tggttcgac  aggatgtgc  4680
tctgagcca  aagatggct  gcagtcagg  tcatcttcc  tctcctcgc  gtcgccctc  4740
tcatctcaa  actatcctt  tgttagccc  tcttccagg  agccattcc  gcccagcaa  4800
gagatgctt  ccggttccc  ggcaccact  ccggggcag  agtccagtg  gccttctga  4860
agcaaagaa  cttcagatg  attagatat  gatgagacg  catcggaca  gagcatgag  4920
ccacagagt  cttcattac  agcaggaga  ggtcagctg  aagaggaag  gaagggcca  4980
aagcggcct  ttggcatgc  ggtccgcat  gcctctgcc  ccagcggga  cgtggcaga  5040
tcaactctt  ttctcacgg  catggcaga  ttccagcag  ttcttcagt  ccccagtct  5100
cggacaaca  ctactgtga  ttggtgctt  ttgaattat  caaaaccca  ttatgtgca  5160
caggccacc  tcaaatcct  ggtttatgc  tcatggtgc  ttagttcct  taatccaaa  5220
ccatcagga  tgaacacca  gaccacgct  gctcttctg  ggtccaagc  aaaaatcac  5280
gcagaaatt  atactctgg  tgctatgca  aggcctgga  ccggcaagc  tacatcatc  5340
agtgcttgg  agcagttta  tcagatgaa  cctgatgcg  cctttttat  tggcagcaa  5400
ctagaaagg  aactagtgg  aaatatctt  aaggaaaga  ggaaaggag  tattcatgg  5460
gataaagat  ttggatcca  acaaactga  ccaatccga  ttaaaatat  tgaaggagg  5520
tacaaatcg  atgaagatt  tgtatatgt  agaggacgt  gccggggaa  gtacatttg  5580
gaagaatgt  ggattcgct  taagaagcc  agcatgctc  aaaaacaca  ccgtaccca  5640
actgatgtt  ggccttatg  atgcaagtt  tgtaacttt  ccttcaaaa  gaaaggaaa  5700
ctaacgaag  atatgaaat  taaagcaca  atgaaaaaa  gcctggaat  gggagtctc  5760
atgacatcg  tggatgata  agaaactga  gaagcagaa  atttggaag  tttgcacaa  5820
gcagcagag  agcatagca  gtccagcat  tcaactgat  atcagttct  cgatgctga  5880
gaatcagat  gtgaggatg  agatgataa  gatgatgat  atgaagatg  agatgactt  5940
gacgaccag  gagatttaa  accaaaaac  agatcaaga  gcaccagtc  tcagcctcc  6000
agattctcc  ccttgcctg  gaatgttgg  gccgtaccc  acggggttc  ttcagatag  6060
tccctggga  attcttcgt  gatcagcta  ttggttact  tgccaagta  tcgagttac  6120
cagcttatg  cacccagtg  ttcatgtga  gatacccag  tgacagaat  ccagaggct  6180
ttccagagc  aaagtacgg  ctcagaacc  gacaaagac  gattggaca  acctagttg  6240
atggatgag  agtgcatgc  accttcaga  ccaagctcc  ctcccaggg  cttctcacc  6300
tcaagccac  attcctctc  aggatatga  tcttcaccc  gtcgagata  ttcaccaaa  6360
aggtatctg  tacccaaag  agatttatc  cccaggaga  atttatcac  taggagaga  6420
ctgtcaccc  tgagacatc  ttcaccaac  aaggaagct  cattgagaa  agagatgtc  6480
caaagagat  tttcaccaa  aaggcattt  tctccaagg  ggccagtgt  tcctgggaa  6540
gatatcaca  caagaagag  cctctcccc  agaagagag  gaagataca  gaccacaat  6600
agagcgcca  ctcccagaa  ggctttata  cataaccca  cattgtcca  gggacagta  6660
ttgcaagca  agccaattg  attggggcc  cctaattta  gaagaggat  acctcaggt  6720
ccttacttc  gtctctatg  agaccaaga  ggtgcttat  aacatccag  ctccagcct  6780
ttccctgag  gtcctaatg  ctatgtctt  agtcatctt  cactccact  tcagcaaca  6840
gtgcgagcc  ctatcccca  ggtgcccgt  ggtgggatc  agatggttc  ctccatgcc  6900
ccagccctt  ccagtttac  tccttcacc  acattgccc  tgccaatgg  gggctttga  6960
gagaagaaa  gcgcgtcag  ggagtcctt  tccaaggac  cctatgtgc  ttctaagca  7020
catgagaag  gaggtcctc  cgctttgca  tcatctggt  cgcctagca  tccctcctc  7080
cctcggctg  tgatgaaac  gagcacttc  gaagacagc  taaacgcaa  agagcggga  7140
caggaggaa  atatacaga  ttgtacaaa  gccattgcc  ctctccgga  tgccacgga  7200
gaggcagct  tgctcgggc  agatcagcc  gcgcgggtg  aggagcccc  ccagaaccc  7260
ctgggaagt  cacatgtta  cattagaca  tttagtaga  ctgagccag  tcagccctg  7320
acctcagcc  cccaccctg  cttgcatga  ggtgaaaag  acaattttg  tacatcaca  7380
actccatta  ctcactcca  gttttacag  aagagttgt  tggatgaca  gcagttgga  7440
tttcacagc  gcaaggaat  atcttcaag  acagaggaa  gcaaagatc  ttcatcaga  7500
aagagtcag  tacattgat  tatgatgca  ggagacttt  atttccaca  tttcccatt  7560
ttttgtttt  gtttttcta  aaatggagg  aatccagtt  atagcatgc  tgtcctaag  7620
tacagtagt  tgctattat  tatactttt  ttatatcaa  agaattagg  aaattaaca  7680
gtcatcatg  gcctgacca  aacaaaatt  gaaattaac  tattgggtc  ggtactttt  7740
aaattgtac  gatgtttgt  ccttttctt  actttgctt  tattcttat  agcattttt  7800
agcagtaat  tgtacatat  ttagaattt  tgtatctgc  ttgtaataa  tgtaatttc  7860
ttccttttt  ggacacttg  atctaaatg  tgtaaagca  aacagcatc  atatatatg  7920
gaggttgca  taaaacata  ttttatatg  ttaaaactg  acagctttt  tgtacagct  7980
tgattctgt  atactaata  ttatttact  tgtttcata  attgtacat  ttttcttaa  8040
gttgtggat  gcttttcta  gtgaagcat  ggatttact  ttgcgtaac  agaacaaaa  8100
tgtacattg  aaacaagat  tttaaacta  agtatctta  tctgcactt  tgcattagt  8160
aaaaaaaga  aaaggatgt  tcagtcagt  cttaactct  gtatatttt  ttgtctctt  8220
tttgctgga  tgactataa  ttaagtgct  attgtgatt  taaaatgat  gtaccgtaa  8280
gcattaaag  aaacaatgt  ctattgtga  ttttttcaa  gctttataa  tcagttata  8340
ataatatta  aagtatttg  tcttatgtg  acatgttga  ctatatact  atctaaaaa  8400
atgggaaaa  attccaccc  atgtaaata  gtacaagtg  atcactggt  caattttat  8460
taactcagt  ggacactag  ttgccacag  cctatgcta  gtgtcttta  aaaattaag  8520
tgacaaagc  catgggact  tgtagagct  ggttatcgg  cggcccggt  gcttggcag  8580
cagtctgtc  ctgctcatg  agaagacct  ggcttagca  tctccttag  tcttgctac  8640
caggatggt  actggaact  aggctacac  gagggtcgc  cttggactc  gagggttgg  8700
tgtggaagg  ggaaaaggg  atggagacc  gctccccag  tcttcctgt  agccggttt  8760
catgggaac  gggttaaca  ctgtgttag  ggaggtcac  ttacccttt  tcatagggg  8820
agagtgtca  actcctggc  atctcaggg  gaatgggga  aagaatctt  caagggcaa  8880
gaactcgtg  gaggatgtc  gttgtatgt  atactcaca  tggcttttg  ttagtgttg  8940
aggtgggaa  agcatttgt  ggtccagaa  agtgaaaga  agggagggg  gcagcaaca  9000
gtgcacagg  acgcacatg  gtgcacgca  acatacaat  tgggttatc  ttgtgctat  9060
tagtggatt  taattctgt  aaaccaagt  tgtatattg  attacatta  ggagtgttc  9120
ttaaaaaga  aaataaata  acaattaca  gcttaaaaa  aaaaaaaaa  aaaaa  9175



<210> 3860
<211> 1833
<212> PRT
<213> Homo sapiens
<308> P31629
<400> 3860

Met Leu Lys Gly Ile Ser Ser Ser Ser Leu Lys Glu Lys Lys Leu Ser 
  1               5                  10                  15
Pro Gly Asp Arg Val Gly Tyr Asp Tyr Asp Val Cys Arg Lys Pro Tyr 
             20                  25                  30
Lys Lys Trp Glu Asp Ser Glu Thr Pro Lys Gln Asn Tyr Arg Asp Ile 
         35                  40                  45
Ser Cys Leu Ser Ser Leu Lys His Gly Gly Glu Tyr Phe Met Asp Pro 
     50                  55                  60
Val Val Pro Leu Gln Gly Val Pro Ser Met Phe Gly Thr Thr Cys Glu 
 65                  70                  75                  80
Asn Arg Lys Arg Arg Lys Glu Lys Ser Val Gly Asp Glu Glu Asp Thr 
                 85                  90                  95
Pro Met Ile Cys Ser Ser Ile Val Ser Thr Pro Val Gly Ile Met Ala 
             100                105                110
Ser Asp Tyr Asp Pro Lys Leu Gln Met Gln Glu Gly Val Arg Ser Gly 
         115                120                125
Phe Ala Met Ala Gly His Glu Asn Leu Ser His Gly His Thr Glu Arg 
     130                135                140
Phe Asp Pro Cys Arg Pro Gln Leu Gln Pro Gly Ser Pro Ser Leu Val 
 145                150                155                160
Ser Glu Glu Ser Pro Ser Ala Ile Asp Ser Asp Lys Met Ser Asp Leu 
                 165                170                175
Gly Gly Arg Lys Pro Pro Gly Asn Val Ile Ser Val Ile Gln His Thr 
             180                185                190
Asn Ser Leu Ser Arg Pro Asn Ser Phe Glu Arg Ser Glu Ser Ala Glu 
         195                200                205
Leu Val Ala Cys Thr Gln Asp Lys Ala Pro Ser Pro Ser Glu Thr Cys 
     210                215                220
Asp Ser Glu Ile Ser Glu Ala Pro Val Ser Pro Glu Trp Ala Pro Pro 
 225                230                235                240
Gly Asp Gly Ala Glu Ser Gly Gly Lys Pro Ser Pro Ser Gln Gln Val 
                 245                250                255
Gln Gln Gln Ser Tyr His Thr Gln Pro Arg Leu Val Arg Gln His Asn 
             260                265                270
Ile Gln Val Pro Glu Ile Arg Val Thr Glu Glu Pro Asp Lys Pro Glu 
         275                280                285
Lys Glu Lys Glu Ala Gln Ser Lys Glu Pro Glu Lys Pro Val Glu Glu 
     290                295                300
Phe Gln Trp Pro Gln Arg Ser Glu Thr Leu Ser Gln Leu Pro Ala Glu 
 305                310                315                320
Lys Leu Pro Pro Lys Lys Lys Arg Leu Arg Leu Ala Asp Met Glu His 
                 325                330                335
Ser Ser Gly Glu Ser Ser Phe Glu Ser Thr Gly Thr Gly Leu Ser Arg 
             340                345                350
Ser Pro Ser Gln Glu Ser Asn Leu Ser His Ser Ser Ser Phe Ser Met 
         355                360                365
Ser Phe Glu Arg Glu Glu Thr Ser Lys Leu Ser Ala Leu Pro Lys Gln 
     370                375                380
Asp Glu Phe Gly Lys His Ser Glu Phe Leu Thr Val Pro Ala Gly Ser 
 385                390                395                400
Tyr Ser Leu Ser Val Pro Gly His His His Gln Lys Glu Met Arg Arg 
                 405                410                415
Cys Ser Ser Glu Gln Met Pro Cys Pro His Pro Ala Glu Val Pro Glu 
             420                425                430
Val Arg Ser Lys Ser Phe Asp Tyr Gly Asn Leu Ser His Ala Pro Val 
         435                440                445
Ser Gly Ala Ala Ala Ser Thr Val Ser Pro Ser Arg Glu Arg Lys Lys 
     450                455                460
Cys Phe Leu Val Arg Gln Ala Ser Phe Ser Gly Ser Pro Glu Ile Ser 
 465                470                475                480
Gln Gly Glu Val Gly Met Asp Gln Ser Val Lys Gln Glu Gln Leu Glu 
                 485                490                495
His Leu His Ala Gly Leu Arg Ser Gly Trp His His Gly Pro Pro Ala 
             500                505                510
Val Leu Pro Pro Leu Gln Gln Glu Asp Pro Gly Lys Gln Val Ala Gly 
         515                520                525
Pro Cys Pro Pro Leu Ser Ser Gly Pro Leu His Leu Ala Gln Pro Gln 
     530                535                540
Ile Met His Met Asp Ser Gln Glu Ser Leu Arg Asn Pro Leu Ile Gln 
 545                550                555                560
Pro Thr Ser Tyr Met Thr Ser Lys His Leu Pro Glu Gln Pro His Leu 
                 565                570                575
Phe Pro His Gln Glu Thr Ile Pro Phe Ser Pro Ile Gln Asn Ala Leu 
             580                585                590
Phe Gln Phe Gln Tyr Pro Thr Val Cys Met Val His Leu Pro Ala Gln 
         595                600                605
Gln Pro Pro Trp Trp Gln Ala His Phe Pro His Pro Phe Ala Gln His 
     610                615                620
Pro Gln Lys Ser Tyr Gly Lys Pro Ser Phe Gln Thr Glu Ile His Ser 
 625                630                635                640
Ser Tyr Pro Leu Glu His Val Ala Glu His Thr Gly Lys Lys Pro Ala 
                 645                650                655
Glu Tyr Ala His Thr Lys Glu Gln Thr Tyr Pro Cys Tyr Ser Gly Ala 
             660                665                670
Ser Gly Leu His Pro Lys Asn Leu Leu Pro Lys Phe Pro Ser Asp Gln 
         675                680                685
Ser Ser Lys Ser Thr Glu Thr Pro Ser Glu Gln Val Leu Gln Glu Asp 
     690                695                700
Phe Ala Ser Ala Asn Ala Gly Ser Leu Gln Ser Leu Pro Gly Thr Val 
 705                710                715                720
Val Pro Val Arg Ile Gln Thr His Val Pro Ser Tyr Gly Ser Val Met 
                 725                730                735
Tyr Thr Ser Ile Ser Gln Ile Leu Gly Gln Asn Ser Pro Ala Ile Val 
             740                745                750
Ile Cys Lys Val Asp Glu Asn Met Thr Gln Arg Thr Leu Val Thr Asn 
         755                760                765
Ala Ala Met Gln Gly Ile Gly Phe Asn Ile Ala Gln Val Leu Gly Gln 
     770                775                780
His Ala Gly Leu Glu Lys Tyr Pro Ile Trp Lys Ala Pro Gln Thr Leu 
 785                790                795                800
Pro Leu Gly Leu Glu Ser Ser Ile Pro Leu Cys Leu Pro Ser Thr Ser 
                 805                810                815
Asp Ser Val Ala Thr Leu Gly Gly Ser Lys Arg Met Leu Ser Pro Ala 
             820                825                830
Ser Ser Leu Glu Leu Phe Met Glu Thr Lys Gln Gln Lys Arg Val Lys 
         835                840                845
Glu Glu Lys Met Tyr Gly Gln Ile Val Glu Glu Leu Ser Ala Val Glu 
     850                855                860
Leu Thr Asn Ser Asp Ile Lys Lys Asp Leu Ser Arg Pro Gln Lys Pro 
 865                870                875                880
Gln Leu Val Arg Gln Gly Cys Ala Ser Glu Pro Lys Asp Gly Leu Gln 
                 885                890                895
Ser Gly Ser Ser Ser Phe Ser Ser Leu Ser Pro Ser Ser Ser Gln Asp 
             900                905                910
Tyr Pro Ser Val Ser Pro Ser Ser Arg Glu Pro Phe Pro Pro Ser Lys 
         915                920                925
Glu Met Leu Ser Gly Ser Arg Ala Pro Leu Pro Gly Gln Lys Ser Ser 
     930                935                940
Gly Pro Ser Glu Ser Lys Glu Ser Ser Asp Glu Leu Asp Ile Asp Glu 
 945                950                955                960
Thr Ala Ser Asp Met Ser Met Ser Pro Gln Ser Ser Ser Leu Pro Ala 
                 965                970                975
Gly Asp Gly Gln Leu Glu Glu Glu Gly Lys Gly His Lys Arg Pro Val 
             980                985                990
Gly Met Leu Val Arg Met Ala Ser Ala Pro Ser Gly Asn Val Ala Asp 
         995                1000                1005
Ser Thr Leu Leu Leu Thr Asp Met Ala Asp Phe Gln Gln Ile Leu Gln 
     1010                1015                1020
Phe Pro Ser Leu Arg Thr Thr Thr Thr Val Ser Trp Cys Phe Leu Asn 
 1025                1030                1035                1040
Tyr Thr Lys Pro Asn Tyr Val Gln Gln Ala Thr Phe Lys Ser Ser Val 
                 1045                1050                1055
Tyr Ala Ser Trp Cys Ile Ser Ser Cys Asn Pro Asn Pro Ser Gly Leu 
             1060                1065                1070
Asn Thr Lys Thr Thr Leu Ala Leu Leu Arg Ser Lys Gln Lys Ile Thr 
         1075                1080                1085
Ala Glu Ile Tyr Thr Leu Ala Ala Met His Arg Pro Gly Thr Gly Lys 
     1090                1095                1100
Leu Thr Ser Ser Ser Ala Trp Lys Gln Phe Thr Gln Met Lys Pro Asp 
 1105                1110                1115                1120
Ala Ser Phe Leu Phe Gly Ser Lys Leu Glu Arg Lys Leu Val Gly Asn 
                 1125                1130                1135
Ile Leu Lys Glu Arg Gly Lys Gly Asp Ile His Gly Asp Lys Asp Ile 
             1140                1145                1150
Gly Ser Lys Gln Thr Glu Pro Ile Arg Ile Lys Ile Phe Glu Gly Gly 
         1155                1160                1165
Tyr Lys Ser Asn Glu Asp Tyr Val Tyr Val Arg Gly Arg Gly Arg Gly 
     1170                1175                1180
Lys Tyr Ile Cys Glu Glu Cys Gly Ile Arg Cys Lys Lys Pro Ser Met 
 1185                1190                1195                1200
Leu Lys Lys His Ile Arg Thr His Thr Asp Val Arg Pro Tyr Val Cys 
                 1205                1210                1215
Lys Leu Cys Asn Phe Ala Phe Lys Thr Lys Gly Asn Leu Thr Lys His 
             1220                1225                1230
Met Lys Ser Lys Ala His Met Lys Lys Cys Leu Glu Leu Gly Val Ser 
         1235                1240                1245
Met Thr Ser Val Asp Asp Thr Glu Thr Glu Glu Ala Glu Asn Leu Glu 
     1250                1255                1260
Asp Leu His Lys Ala Ala Glu Lys His Ser Met Ser Ser Ile Ser Thr 
 1265                1270                1275                1280
Asp His Gln Phe Ser Asp Ala Glu Glu Ser Asp Gly Glu Asp Gly Asp 
                 1285                1290                1295
Asp Asn Asp Asp Asp Asp Glu Asp Glu Asp Asp Phe Asp Asp Gln Gly 
             1300                1305                1310
Asp Leu Thr Pro Lys Thr Arg Ser Arg Ser Thr Ser Pro Gln Pro Pro 
         1315                1320                1325
Arg Phe Ser Ser Leu Pro Val Asn Val Gly Ala Val Pro His Gly Val 
     1330                1335                1340
Pro Ser Asp Ser Ser Leu Gly His Ser Ser Leu Ile Ser Tyr Leu Val 
 1345                1350                1355                1360
Thr Leu Pro Ser Ile Arg Val Thr Gln Leu Met Thr Pro Ser Asp Ser 
                 1365                1370                1375
Cys Glu Asp Thr Gln Met Thr Glu Tyr Gln Arg Leu Phe Gln Ser Lys 
             1380                1385                1390
Ser Thr Asp Ser Glu Pro Asp Lys Asp Arg Leu Asp Ile Pro Ser Cys 
         1395                1400                1405
Met Asp Glu Glu Cys Met Leu Pro Ser Glu Pro Ser Ser Ser Pro Arg 
     1410                1415                1420
Asp Phe Ser Pro Ser Ser His His Ser Ser Pro Gly Tyr Asp Ser Ser 
 1425                1430                1435                1440
Pro Cys Arg Asp Asn Ser Pro Lys Arg Tyr Leu Ile Pro Lys Gly Asp 
                 1445                1450                1455
Leu Ser Pro Arg Arg His Leu Ser Pro Arg Arg Asp Leu Ser Pro Met 
             1460                1465                1470
Arg His Leu Ser Pro Arg Lys Glu Ala Ala Leu Arg Arg Glu Met Ser 
         1475                1480                1485
Gln Arg Asp Val Ser Pro Arg Arg His Leu Ser Pro Arg Arg Pro Val 
     1490                1495                1500
Ser Pro Gly Lys Asp Ile Thr Ala Arg Arg Asp Leu Ser Pro Arg Arg 
 1505                1510                1515                1520
Glu Arg Arg Tyr Met Thr Thr Ile Arg Ala Pro Ser Pro Arg Arg Ala 
                 1525                1530                1535
Leu Tyr His Asn Pro Pro Leu Ser Met Gly Gln Tyr Leu Gln Ala Glu 
             1540                1545                1550
Pro Ile Val Leu Gly Pro Pro Asn Leu Arg Arg Gly Leu Pro Gln Val 
         1555                1560                1565
Pro Tyr Phe Ser Leu Tyr Gly Asp Gln Glu Gly Ala Tyr Glu His Pro 
     1570                1575                1580
Gly Ser Ser Leu Phe Pro Glu Gly Pro Asn Asp Tyr Val Phe Ser His 
 1585                1590                1595                1600
Leu Pro Leu His Ser Gln Gln Gln Val Arg Ala Pro Ile Pro Met Val 
                 1605                1610                1615
Pro Val Gly Gly Ile Gln Met Val His Ser Met Pro Pro Ala Leu Ser 
             1620                1625                1630
Ser Leu His Pro Ser Pro Thr Leu Pro Leu Pro Met Glu Gly Phe Glu 
         1635                1640                1645
Glu Lys Lys Gly Ala Ser Gly Glu Ser Phe Ser Lys Asp Pro Tyr Val 
     1650                1655                1660
Leu Ser Lys Gln His Glu Lys Arg Gly Pro His Ala Leu Gln Ser Ser 
 1665                1670                1675                1680
Gly Pro Pro Ser Thr Pro Ser Ser Pro Arg Leu Leu Met Lys Gln Ser 
                 1685                1690                1695
Thr Ser Glu Asp Ser Leu Asn Ala Thr Glu Arg Glu Gln Glu Glu Asn 
             1700                1705                1710
Ile Gln Thr Cys Thr Lys Ala Ile Ala Ser Leu Arg Ile Ala Thr Glu 
         1715                1720                1725
Glu Ala Ala Leu Leu Gly Pro Asp Gln Pro Ala Arg Val Gln Glu Pro 
     1730                1735                1740
His Gln Asn Pro Leu Gly Ser Ala His Val Ser Ile Arg His Phe Ser 
 1745                1750                1755                1760
Arg Pro Glu Pro Gly Gln Pro Cys Thr Ser Ala Thr His Pro Asp Leu 
                 1765                1770                1775
His Asp Gly Glu Lys Asp Asn Phe Gly Thr Ser Gln Thr Pro Leu Ala 
             1780                1785                1790
His Ser Thr Phe Tyr Ser Lys Ser Cys Val Asp Asp Lys Gln Leu Asp 
         1795                1800                1805
Phe His Ser Ser Lys Glu Leu Ser Ser Ser Thr Glu Glu Ser Lys Asp 
     1810                1815                1820
Pro Ser Ser Glu Lys Ser Gln Leu His 
 1825                1830



<210> 3861
<211> 3635
<212> DNA
<213> Rattus norvegicus
<308> M68971
<400> 3861

cggaaaacc  gtttctgga  acgcgaggc  ctcagctgg  gagccatcg  ggttaagct  60
ctttgtgtg  ctcctggag  ctccgatcc  agccggaca  ccgggcctg  tttcaaagc  120
gtcgaactg  tctgcccgc  ccaccggta  cgctcgagc  tcggtttct  tactcgacc  180
cgactcgcc  cagcaggat  atcgcctcg  atatgatcg  ctgcttatt  acggagctc  240
accaaaacc  agtgcagaa  gttgaccaa  ttctctacc  catgcgtct  tcagatgag  300
cccttctgg  gatttctag  cggttccgg  aggagatgg  gaaagggct  ggagctacc  360
cgcacccta  agcagctgt  aaaatgttg  ctacctttg  gaggtcaac  ccggatggg  420
cagaacatg  ggagttcct  gctctggat  ttggaggaa  caacttccg  gtgctccga  480
taagggtga  ggacaatgg  ctccagaga  tggagatgg  gaaccagat  tacgccatc  540
ctgaggaca  catgcgggg  agtggaacc  agctgtttg  ccacatcgc  gaatgcctg  600
ccaacttca  ggacaagct  caaatcaaa  agaagaagc  ccctctggg  ttcaccttc  660
cgttcccct  ccaccagac  aaactggat  agagttttt  ggtctcgtg  actaagggg  720
tcaagtcca  tggcgtgga  ggcagagat  tggtggacc  gatccggaa  gctatccag  780
gcagagggg  ctttgacat  gacattgtg  ccgtggtga  tgacacagt  gggaccatg  840
tgacttgtg  ctatgatga  cagaactgc  agattggtc  cattgtggg  actggcagc  900
acgcctgct  catggagga  atgcgtcat  ttgacatgg  ggagggaga  gaggggcgc  960
tgtgcatca  catggagtg  ggagccttt  gggacgacg  tacactcaa  gacatccga  1020
ccgagtttg  ccgagagat  gacatgggc  cgctgaacc  tgggaagca  ctgtttgag  1080
agatgatta  cgggatgta  atgggggag  tggtcaggc  catcctggt  aagatggcc  1140
aggcagagc  gttgttcca  gggaaactc  gcccagaac  ccttaccac  ggctccttc  1200
agaccaaag  tgtctcgga  attgaagag  ataaggatg  aatcgagaa  gcctaccaa  1260
tcctgatgc  cctgggtct  aatccattg  aggaggatt  tgtggccac  caccgaatc  1320
gccagattg  gtccacgcg  tcggccagt  tgtgcgcag  caccctggc  gcggtgctg  1380
ggcgaatca  agagaacaa  ggcgaggag  gacttcgct  caccatcgg  gtcgatggc  1440
ccgtctaca  gaaacatcc  cattttgcc  agcgtctcc  taaggcagt  aggaggctg  1500
tgcccgact  tgatgtccg  ttcctccgc  ctgaggatg  cagcggcaa  ggggctgct  1560
tggtgacgg  ggtggctta  cgtctggct  accaacacc  ggcccgcca  aagaccctg  1620
agtctctga  gctgagcca  gagcagctt  tggaggtta  gagaagaat  aaggtggaa  1680
tggagcagg  tctgagcaa  gagacgcat  cggtcgccc  tgtgaagat  ctgcccact  1740
acgtgtgtg  cactccaga  ggcacagag  aaggagact  cttggcctt  gatcttgga  1800
gaacaaact  ccgggtcct  ctggtgcgt  tgcgtaatg  caagcggag  ggcgtggag  1860
tgcataaca  gatctactc  atcccacag  aggttatgc  tggcactgg  gaagagctc  1920
tcgaccaca  tgtccagtg  attgcggac  tcctggagt  catgggcat  aagggcgtg  1980
ccctgcctt  gggtttcac  ttctccttc  cttgccagc  gaacagcct  gaccagagc  2040
tcctcctca  gtggacaaa  ggattcaag  catctggct  cgagggtga  gatgtggtc  2100
ccttgctga  ggaagcgat  caccggcga  aggagtttg  cctggatgt  gttgccgtg  2160
tgaatgaca  agttgggac  atgatgact  gtggctacg  agaccctca  tgtgaagtt  2220
gcctcattg  tggcaccgg  agcaacgcc  gctacatgg  agagatgcg  aatgtggag  2280
tggtggacg  agaggaggg  cggatgtgt  tcaacatgg  gtggggagc  tttggggac  2340
atggctgcc  ggatgactt  cggaccgtg  ttgatgttg  tgtggatga  ctttctctc  2400
accctggca  acagaggtt  gagaagatg  tcagcggca  gtacttggg  gagattgtg  2460
gcaacattc  catcgattt  acgaagcgg  ggctgctct  ccgaggccg  atctcagag  2520
gcctcaaga  aaggggaat  tttgaaact  agttcctgt  tcagataga  agcgactgc  2580
tagccctgc  acaggttcg  gccatcctg  gccacctag  gctggagag  acgtgcgat  2640
acagcatca  cgtgaagga  gtgtgcact  tggttgccc  gcgcgctgc  cagctctgt  2700
gcgcaggca  ggccgccgt  gtggacaag  taagagaga  ccgtgggct  gacaacctc  2760
aagtgacag  gggcgtgga  gggactctg  ataagcttc  tcctcactt  gccaaggtc  2820
tgcatgaga  ggtgagaga  ctggctccg  aatgtgacg  gtccttcct  gaatccgag  2880
acggcagtg  gaagggagc  gctctcatc  ctgccgtgg  ctgccgcat  cgggaggct  2940
ggcagagat  gaagcttgg  gaccagacg  ggcttctct  cttcctcac  tccccgttt  3000
aaattatga  aagatggac  ccttggcag  gaggaccct  tgagactgg  acttttgtc  3060
ctgtatatt  actgtagag  ttggtaccc  atccttggc  ttcctgaga  tctgaagta  3120
ggagttgtt  gcagttcct  ctggtcacc  cctgggatg  tcctccccc  ctctacttc  3180
tgtacaatc  tatgggatg  ggacagtct  gagaaaatg  ttgcctcag  ttggagctg  3240
acctgacat  tgtaggtgg  gaacatctt  aaatgtcga  gcttctctc  tcagaggta  3300
atgttgggt  ggagggagg  ggagagata  gacgtcccc  gccctacgt  gctgtccct  3360
ttcaactca  cccataagc  tcaccctgc  ggttctaaa  catttgctg  cctgggata  3420
aggaatctg  accaaagct  gagtggacg  cttcttcaa  tgtttgtgg  tttacctca  3480
atggctgaa  gtgtcatcc  cgagctaca  accttgggg  caggagtgg  tttggtcgc  3540
ttttagttt  ttgttttgt  ttgtttttt  cttttttaa  ttatgtttg  aatttactt  3600
gtttaaagc  ggtcctctc  attgtgtaa  ggttg  3635



<210> 3862
<211> 917
<212> PRT
<213> Rattus norvegicus
<308> P27881
<400> 3862

Met Ile Ala Ser His Met Ile Ala Cys Leu Phe Thr Glu Leu Asn Gln 
  1               5                  10                  15
Asn Gln Val Gln Lys Val Asp Gln Phe Leu Tyr His Met Arg Leu Ser 
             20                  25                  30
Asp Glu Thr Leu Leu Glu Ile Ser Arg Arg Phe Arg Lys Glu Met Glu 
         35                  40                  45
Lys Gly Leu Gly Ala Thr Thr His Pro Thr Ala Ala Val Lys Met Leu 
     50                  55                  60
Pro Thr Phe Val Arg Ser Thr Pro Asp Gly Thr Glu His Gly Glu Phe 
 65                  70                  75                  80
Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Arg Val Arg 
                 85                  90                  95
Val Thr Asp Asn Gly Leu Gln Arg Val Glu Met Glu Asn Gln Ile Tyr 
             100                105                110
Ala Ile Pro Glu Asp Ile Met Arg Gly Ser Gly Thr Gln Leu Phe Asp 
         115                120                125
His Ile Ala Glu Cys Leu Ala Asn Phe Met Asp Lys Leu Gln Ile Lys 
     130                135                140
Glu Lys Lys Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys His Gln 
 145                150                155                160
Thr Lys Leu Asp Glu Ser Phe Leu Val Ser Trp Thr Lys Gly Phe Lys 
                 165                170                175
Ser Ser Gly Val Glu Gly Arg Asp Val Val Asp Leu Ile Arg Lys Ala 
             180                185                190
Ile Gln Arg Arg Gly Asp Phe Asp Ile Asp Ile Val Ala Val Val Asn 
         195                200                205
Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp Gln Asn Cys 
     210                215                220
Glu Ile Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
 225                230                235                240
Glu Met Arg His Ile Asp Met Val Glu Gly Asp Glu Gly Arg Met Cys 
                 245                250                255
Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asp Gly Thr Leu Asn Asp 
             260                265                270
Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp Met Gly Ser Leu Asn Pro 
         275                280                285
Gly Lys Gln Leu Phe Glu Lys Met Ile Ser Gly Met Tyr Met Gly Glu 
     290                295                300
Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Ala Glu Leu Leu Phe 
 305                310                315                320
Gln Gly Lys Leu Ser Pro Glu Leu Leu Thr Thr Gly Ser Phe Glu Thr 
                 325                330                335
Lys Asp Val Ser Asp Ile Glu Glu Asp Lys Asp Gly Ile Glu Lys Ala 
             340                345                350
Tyr Gln Ile Leu Met Arg Leu Gly Leu Asn Pro Leu Gln Glu Asp Cys 
         355                360                365
Val Ala Thr His Arg Ile Cys Gln Ile Val Ser Thr Arg Ser Ala Ser 
     370                375                380
Leu Cys Ala Ala Thr Leu Ala Ala Val Leu Trp Arg Ile Lys Glu Asn 
 385                390                395                400
Lys Gly Glu Glu Arg Leu Arg Ser Thr Ile Gly Val Asp Gly Ser Val 
                 405                410                415
Tyr Lys Lys His Pro His Phe Ala Lys Arg Leu His Lys Ala Val Arg 
             420                425                430
Arg Leu Val Pro Asp Cys Asp Val Arg Phe Leu Arg Ser Glu Asp Gly 
         435                440                445
Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
     450                455                460
Asp Gln His Arg Ala Arg Gln Lys Thr Leu Glu Ser Leu Lys Leu Ser 
 465                470                475                480
His Glu Gln Leu Leu Glu Val Lys Arg Arg Met Lys Val Glu Met Glu 
                 485                490                495
Gln Gly Leu Ser Lys Glu Thr His Ala Val Ala Pro Val Lys Met Leu 
             500                505                510
Pro Thr Tyr Val Cys Ala Thr Pro Asp Gly Thr Glu Lys Gly Asp Phe 
         515                520                525
Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Arg 
     530                535                540
Val Arg Asn Gly Lys Arg Arg Gly Val Glu Met His Asn Lys Ile Tyr 
 545                550                555                560
Ser Ile Pro Gln Glu Val Met His Gly Thr Gly Glu Glu Leu Phe Asp 
                 565                570                575
His Ile Val Gln Cys Ile Ala Asp Phe Leu Glu Tyr Met Gly Met Lys 
             580                585                590
Gly Val Ser Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
         595                600                605
Asn Ser Leu Asp Gln Ser Ile Leu Leu Lys Trp Thr Lys Gly Phe Lys 
     610                615                620
Ala Ser Gly Cys Glu Gly Glu Asp Val Val Thr Leu Leu Lys Glu Ala 
 625                630                635                640
Ile His Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                 645                650                655
Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Glu Asp Pro His Cys 
             660                665                670
Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
         675                680                685
Glu Met Arg Asn Val Glu Leu Val Asp Gly Glu Glu Gly Arg Met Cys 
     690                695                700
Val Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
 705                710                715                720
Leu Arg Thr Val Phe Asp Val Ala Val Asp Glu Leu Ser Leu Asn Pro 
                 725                730                735
Gly Lys Gln Arg Phe Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
             740                745                750
Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Arg Gly Leu Leu Phe 
         755                760                765
Arg Gly Arg Ile Ser Glu Arg Leu Lys Thr Arg Gly Ile Phe Glu Thr 
     770                775                780
Lys Phe Leu Ser Gln Ile Glu Ser Asp Cys Leu Ala Leu Leu Gln Val 
 785                790                795                800
Arg Ala Ile Leu Arg His Leu Gly Leu Glu Ser Thr Cys Asp Asp Ser 
                 805                810                815
Ile Ile Val Lys Glu Val Cys Thr Val Val Ala Arg Arg Ala Ala Gln 
             820                825                830
Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys Ile Arg Glu Asn 
         835                840                845
Arg Gly Leu Asp Asn Leu Lys Val Thr Val Gly Val Asp Gly Thr Leu 
     850                855                860
Tyr Lys Leu His Pro His Phe Ala Lys Val Met His Glu Thr Val Arg 
 865                870                875                880
Asp Leu Ala Pro Lys Cys Asp Val Ser Phe Leu Glu Ser Glu Asp Gly 
                 885                890                895
Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Cys Arg Ile Arg 
             900                905                910
Glu Ala Gly Gln Arg 
         915



<210> 3863
<211> 3476
<212> DNA
<213> Homo sapiens
<308> AF148513
<400> 3863

gttgcatga  actccggcg  aggagtccc  ggctgccgc  ggcaacatc  tgtcaccca  60
ctaagaaaa  ccgcgggcc  gagccacgc  cctgtgaat  ggagaggtc  cactgcccg  120
gtggagccg  gctgagatt  ttctcaagt  gagcctcag  gatcctgtg  ccgaagtta  180
cgccttgac  tgggacaac  ggacacgtc  ccaggagag  actgaggcg  cttctagca  240
ttgtgacgc  aaaatcacg  ctccggaga  ccgcgccct  cgccagccg  gcgcaccct  300
gccggtagc  ttctttgtg  gccgtccgg  ctcccagct  ccggcccgg  agccgagcc  360
cagcacaaa  cagtcggac  gcgccgccc  cctcccctc  cgcgtctcc  cctcggttt  420
ccaactctg  gccgtcggg  cgcggcagg  tgattgcct  gcatctgct  gcctacttc  480
tcacggagc  caaccatga  caagtgcag  aggttgacc  gtatctcta  cacatgcgc  540
tctctgatg  gaccctctt  gagatctct  agcggttcc  caaggagat  gagaaaggg  600
ttggagcca  cactcaccc  actgcagca  tgaagatgc  gcccacctt  gtgaggtcc  660
ctccagatg  gacagaaca  ggagagttc  tggctctgg  tcttggagg  accaacttc  720
gtgtgcttt  ggtgaaagt  acggacaat  ggctccaga  ggtggagat  gagaatcag  780
tctatgcca  ccctgagga  atcatgcga  gcagtggca  ccagctgtt  gaccacatt  840
ccgaatgcc  ggctaactt  atggataag  tacaaatca  agacaagaa  ctcccactg  900
gttttacct  ctcgttccc  tgccaccag  ctaaactag  cgagagttt  ctggtctca  960
ggaccaagg  attcaagtc  agtggagtg  aaggcagag  cgttgtggc  ctgatccgg  1020
aggccatcc  gaggagagg  gactttgat  tcgacattg  ggctgtggt  aatgacaca  1080
ttgggacca  gatgacctg  ggttatgat  accacaact  tgagattgg  ctcattgtg  1140
gcacgggca  caacgcctg  tacatggaa  agatgcgcc  catcgacat  gtggaaggc  1200
atgaggggc  gatgtgtat  aatatggag  ggggggcct  cggggacga  ggctcgctc  1260
acgacattc  cactgagtt  gaccaggag  ttgacatgg  ctcactgaa  ccgggaaag  1320
aactgtttg  gaagatgat  agtgggatg  acatggggg  gctggtgag  cttatcctg  1380
tgaagatgg  caaggagga  ctgctcttt  gggggaagc  cagcccaga  cttctcaac  1440
ccggtcgct  tgagaccaa  gacatctca  acattgaag  ggagaagga  ggcatccgg  1500
aggcccgtg  ggtcctgat  cggttgggc  tggacccga  tcaggagga  tgcgtggcc  1560
ctcaccgga  ctgccagat  gtgtccaca  gctccgcca  cctgtgcgc  gccaccctg  1620
ccgccgtgc  gcagcgcat  aaggagaac  aaggcgagg  gcggctgcg  tctactatt  1680
gggtcgacg  ttccgtcta  aagaaacac  cccattttg  caagcgtct  cataagacc  1740
tgcggcggc  ggtgcccgg  tgcgatgtc  gcttcctcc  ctccgagga  ggcagtggc  1800
aaggtgcag  catggtgac  gcagtggct  accggctgg  cgatcaaca  cgtgcccgc  1860
agaagacat  agagcatct  cagctgagc  atgaccagc  gctggaggt  aagaggagg  1920
tgaaggtag  aatggagcg  ggtctgagc  aggagactc  tgccagtgc  cccgtcaag  1980
tgctgccca  ctacgtgtg  gctaccccg  acggcacag  gaaagggga  ttcttggcc  2040
tggaccttg  aggaacaaa  ttccgggtc  tgctggtcc  tgttcggaa  gggaagtgg  2100
gtggagtgg  gatgcacaa  aagatctac  ccatcccgc  ggaggtcat  cacggcacc  2160
gggacgagc  ctttgacca  attgtccag  gcatcgcgg  cttcctcga  tacatgggc  2220
tgaagggcg  gtccctgcc  ctgggtttt  ccttctcct  cccctgcca  cagaacagc  2280
tggacgaga  catcctcct  aagtggaca  aaggcttca  ggcatctgg  tgcgagggc  2340
aggacgtgg  gaccctgct  aaggaagcg  tccaccggc  agaggagtt  gacctggat  2400
tggttgctg  ggtgaacga  acagtcgga  ctatgatga  ctgtggctt  gaagaccct  2460
actgtgaag  tggcctcat  gttggcacg  gcagcaatg  ctgctacat  gaggagatg  2520
gcaacgtgg  actggtgga  ggagaagag  ggcggatgt  tgtgaacat  gaatggggg  2580
cattcgggg  caatggatg  ctagatgac  tccgcacag  atttgatgt  gctgtggat  2640
agctttcac  caaccccgg  aagcagagg  tcgagaaaa  gatcagtgg  atgtacctg  2700
gtgagattg  ccgtaacat  ctcatcgat  tcaccaagc  tggactgct  ttccgaggc  2760
gcatctcag  gcggctcaa  acaaggggc  tctttgaaa  caagttctt  tctcagatt  2820
agagtgact  cctggccct  ctgcaagtc  gagccatcc  gcaacactt  gggcttgag  2880
gcacctgtg  cgacagcat  attgttaag  aggtgtgca  tgtggtggc  cggcgggca  2940
cccagctct  tggcgcagg  atggccgct  tggtggaca  gatacgaga  aaccgtggg  3000
tggacgctc  caaagtgac  gtgggtgtg  atgggaccc  ctacaagct  catcctcac  3060
ttgccaaag  catgcatga  acagtgaag  acctggctc  gaaatgtga  gtgtctttc  3120
tgcagtcag  ggatggcag  gggaagggg  cggcgctca  cactgctgt  gcctgccgc  3180
tccgtgagg  tggacagcg  tagaacccc  gaaatcgga  gggacttcc  ctttctctc  3240
ttcttccct  ttttaaatt  taagatgtc  tccccttgt  tcagagaca  accccttgg  3300
ttttgcttg  cagagagga  cccactgga  tgggttttg  ctctgcatc  cattgtaga  3360
cttggtggc  gagcttggc  ctattaaga  aaatagagt  ccaaataag  atttgttca  3420
atgcatcat  accattccc  ttggttctc  taaaacatg  aaattatct  ccttag  3476



<210> 3864
<211> 917
<212> PRT
<213> Homo sapiens
<308> P52789
<400> 3864

Met Ile Ala Ser His Leu Leu Ala Tyr Phe Phe Thr Glu Leu Asn His 
  1               5                  10                  15
Asp Gln Val Gln Lys Val Asp Gln Tyr Leu Tyr His Met Arg Leu Ser 
             20                  25                  30
Asp Glu Thr Leu Leu Glu Ile Ser Lys Arg Phe Arg Lys Glu Met Glu 
         35                  40                  45
Lys Gly Leu Gly Ala Thr Thr His Pro Thr Ala Ala Val Lys Met Leu 
     50                  55                  60
Pro Thr Phe Val Arg Ser Thr Pro Asp Gly Thr Glu His Gly Glu Phe 
 65                  70                  75                  80
Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Trp Val Lys 
                 85                  90                  95
Val Thr Asp Asn Gly Leu Gln Lys Val Glu Met Glu Asn Gln Ile Tyr 
             100                105                110
Ala Ile Pro Glu Asp Ile Met Arg Gly Ser Gly Thr Gln Leu Phe Asp 
         115                120                125
His Ile Ala Glu Cys Leu Ala Asn Phe Met Asp Lys Leu Gln Ile Lys 
     130                135                140
Asp Lys Lys Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys His Gln 
 145                150                155                160
Thr Lys Leu Asp Glu Ser Phe Leu Val Ser Trp Thr Lys Gly Phe Lys 
                 165                170                175
Ser Ser Gly Val Glu Gly Arg Asp Val Val Ala Leu Ile Arg Lys Ala 
             180                185                190
Ile Gln Arg Arg Gly Asp Phe Asp Ile Asp Ile Val Ala Val Val Asn 
         195                200                205
Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp His Asn Cys 
     210                215                220
Glu Ile Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
 225                230                235                240
Glu Met Arg His Ile Asp Met Val Glu Gly Asp Glu Gly Arg Met Cys 
                 245                250                255
Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Asn Asp 
             260                265                270
Ile Arg Thr Glu Phe Asp Gln Glu Ile Asp Met Gly Ser Leu Asn Pro 
         275                280                285
Gly Lys Gln Leu Phe Glu Lys Met Ile Ser Gly Met Tyr Met Gly Glu 
     290                295                300
Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Glu Leu Leu Phe 
 305                310                315                320
Gly Gly Lys Leu Ser Pro Glu Leu Leu Asn Thr Gly Arg Phe Glu Thr 
                 325                330                335
Lys Asp Ile Ser Asp Ile Glu Gly Glu Lys Asp Gly Ile Arg Lys Ala 
             340                345                350
Arg Glu Val Leu Met Arg Leu Gly Leu Asp Pro Thr Gln Glu Asp Cys 
         355                360                365
Val Ala Thr His Arg Ile Cys Gln Ile Val Ser Thr Arg Ser Ala Ser 
     370                375                380
Leu Cys Ala Ala Thr Leu Ala Ala Val Leu Gln Arg Ile Lys Glu Asn 
 385                390                395                400
Lys Gly Glu Glu Arg Leu Arg Ser Thr Ile Gly Val Asp Gly Ser Val 
                 405                410                415
Tyr Lys Lys His Pro His Phe Ala Lys Arg Leu His Lys Thr Val Arg 
             420                425                430
Arg Leu Val Pro Gly Cys Asp Val Arg Phe Leu Arg Ser Glu Asp Gly 
         435                440                445
Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
     450                455                460
Asp Gln His Arg Ala Arg Gln Lys Thr Leu Glu His Leu Gln Leu Ser 
 465                470                475                480
His Asp Gln Leu Leu Glu Val Lys Arg Arg Met Lys Val Glu Met Glu 
                 485                490                495
Arg Gly Leu Ser Lys Glu Thr His Ala Ser Ala Pro Val Lys Met Leu 
             500                505                510
Pro Thr Tyr Val Cys Ala Thr Pro Asp Gly Thr Glu Lys Gly Asp Phe 
         515                520                525
Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Arg 
     530                535                540
Val Arg Asn Gly Lys Trp Gly Gly Val Glu Met His Asn Lys Ile Tyr 
 545                550                555                560
Ala Ile Pro Gln Glu Val Met His Gly Thr Gly Asp Glu Leu Phe Asp 
                 565                570                575
His Ile Val Gln Cys Ile Ala Asp Phe Leu Glu Tyr Met Gly Met Lys 
             580                585                590
Gly Val Ser Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
         595                600                605
Asn Ser Leu Asp Glu Ser Ile Leu Leu Lys Trp Thr Lys Gly Phe Lys 
     610                615                620
Ala Ser Gly Cys Glu Gly Glu Asp Val Val Thr Leu Leu Lys Glu Ala 
 625                630                635                640
Ile His Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                 645                650                655
Asp Thr Val Gly Thr Met Met Thr Cys Gly Phe Glu Asp Pro His Cys 
             660                665                670
Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
         675                680                685
Glu Met Arg Asn Val Glu Leu Val Glu Gly Glu Glu Gly Arg Met Cys 
     690                695                700
Val Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
 705                710                715                720
Phe Arg Thr Glu Phe Asp Val Ala Val Asp Glu Leu Ser Leu Asn Pro 
                 725                730                735
Gly Lys Gln Arg Phe Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
             740                745                750
Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Arg Gly Leu Leu Phe 
         755                760                765
Arg Gly Arg Ile Ser Glu Arg Leu Lys Thr Arg Gly Ile Phe Glu Thr 
     770                775                780
Lys Phe Leu Ser Gln Ile Glu Ser Asp Cys Leu Ala Leu Leu Gln Val 
 785                790                795                800
Arg Ala Thr Leu Gln His Leu Gly Leu Glu Ser Thr Cys Asp Asp Ser 
                 805                810                815
Ile Ile Val Lys Glu Val Cys Thr Val Val Ala Arg Arg Ala Ala Gln 
             820                825                830
Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Arg Ile Arg Glu Asn 
         835                840                845
Arg Gly Leu Asp Ala Leu Lys Val Thr Val Gly Val Asp Gly Thr Leu 
     850                855                860
Tyr Lys Leu His Pro His Phe Ala Lys Val Met His Glu Thr Val Lys 
 865                870                875                880
Asp Leu Ala Pro Lys Cys Asp Val Ser Phe Leu Gln Ser Glu Asp Gly 
                 885                890                895
Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Cys Arg Ile Arg 
             900                905                910
Glu Ala Gly Gln Arg 
         915



<210> 3865
<211> 2977
<212> DNA
<213> Rattus norvegicus
<308> M73714
<400> 3865

gaattcggc  gatggaagc  agctgtccc  agaagcagt  aactgtggc  tcatcccga  60
cagtgcctt  ccggtattg  gctgcttca  ctgcctcgc  cggcgttct  ctcaggccc  120
gccatggag  gacaggtcc  acgacttcg  cagacgttc  ggtccggcc  atcgcggcc  180
ctgcgtttc  gactgcagc  gctcgaggc  ctccggagg  tggtgcaag  gcgagagaa  240
gacatcttg  cagccatcg  agcagacct  agcaaaagt  aactcaatg  atacagtca  300
gaagtcatt  ccatccttg  ggagattga  ttcatgctg  ggaatcttc  tgaattggc  360
tctgctcgg  cagcgaaga  gaacctgct  accatgatg  acgaggcct  tgttcagcc  420
gagcctctg  gagtcgtgc  gattattgg  gcttggaac  atccttttg  tctgaccct  480
cagccactg  tgggagcca  tgctgcagg  aatgctgcc  ttgttaagc  ctcggaact  540
agtgaaaac  cggctaaga  cttggctga  ctcctccct  agtatttag  ccaggacct  600
tacatgatt  ttaatggcg  cgttgaaga  accacagag  ttctgaggc  gcggtttga  660
cacattctc  acacaggaa  caccgcagt  ggaaaaatt  tcatggagg  tgctgccaa  720
cacctgacc  ctgtgaccc  ggagctcgg  ggcaaaagc  catgctaca  tgacagaga  780
tgtgacctg  acgttgctt  cagacggat  acctgggga  agtacatga  ttgtggtca  840
acctgtatt  ctcctgact  tatcctgtg  gaagcctcc  cccaggatc  aatcgtaca  900
aagattaag  atacggtga  ggactttta  ggggaaaat  taaaagctt  tcctgatta  960
gaaaggatc  tcaaccttc  tcactttaa  aggataaaa  gtttgcttg  aggacagaa  1020
atagctttt  gtggggaga  tgatgaagc  acacgctac  tagccccaa  catactcac  1080
gatgttgac  ctaactcca  ggtgatgca  gaagaaatt  ttggaccaa  tctcccaat  1140
gtgtctgtg  aaaatgtgg  ggaagccat  aatttcata  atgatcgcg  aaagcccct  1200
gcactctac  tattttctc  caacaataa  ctcatcaaa  gggtgattg  tgagacatc  1260
agtggtgga  tcacaggca  tgatgtcat  atgcacttc  ctgttaatt  tttgccctt  1320
ggaggtgtg  gtgccagtg  aatgggggc  tatcatggc  aatacagtt  cgatacctt  1380
tctcatcag  gcccctgct  gttaaaagg  ttaaaggga  agagtgtta  caaactcag  1440
taccctccc  acagcgagt  caaggtcag  tggtcgaaa  tcttcctgc  gaaacagtt  1500
aacaaagga  ggctgcagc  gctgcttct  gtgtgcttg  ttgcggttg  agctgtgat  1560
gtcaaggat  agctgtgat  acttccttg  agcctctac  gaagtaccc  tcggccaaa  1620
ggttaacac  ccaatgctt  taaaattgt  cccaaacca  gaaatgaaa  tcacaggtg  1680
actgcagtc  aacctaagt  gttgccaca  accactgat  aaactcagt  cttcagcca  1740
atcccagca  ttgtcagcc  tgcaggtgc  gagagggtg  agactggga  gggcgacac  1800
tagtccatg  cagcgggat  tcagggaga  tcgacaact  ctcccgcac  ctttgctcc  1860
ggacatagc  ctcccaccc  gtgtcaaca  cctccaggc  ttccagctg  cctctgatt  1920
ctgaggttc  tgttaggga  ccaggtact  aacctgggc  ggtggattt  tcggcctca  1980
ccattgtgg  tcgagaccg  ccttcggga  tcggctctc  gtctaaaca  cctttctca  2040
tcatagtgt  tcacccgaa  atgcttgtt  gtgacattg  gacagtctg  catgactgt  2100
ccggtgcct  tgtgatgac  taaactaca  tgaggagct  gccaacttg  gaatgccct  2160
cagagggtc  ggcagtcac  gctgttcca  agcccgagg  acgaagatt  cggagcccg  2220
agtttgagg  caacctagg  aacataatg  gaccctctc  ttattattc  tccataaca  2280
tcccctcga  accctcgat  tgaatgtta  ataggtctt  aggataaat  tgcttattt  2340
cacagcaca  cacaaaaaa  atttacttt  gaaatctta  agagattcc  acagatctt  2400
gcatggagc  gttcctgta  tgaaagggg  gttattaga  atgaggctt  agaactcat  2460
gggcagggt  gttggagac  accgtgagc  gagggggca  actgaagcg  tgggatggc  2520
agaagcgca  ctgagcaag  ggggcagca  tctctgtca  accctaaca  ggctacacg  2580
ggatgtggc  gagagatct  tgccgttgg  tgccagcgc  ggttaggcc  gaagctcca  2640
gctgcagag  tctcattgc  ttcccagga  ccaaattaa  actgcccac  caatgagaa  2700
gtcacttgc  tatgtacaa  catgtttgc  gagtaacct  ttccaccgt  gaggctgtc  2760
gaagtgtat  gtatgaggt  tcaagaacg  gtcattggc  catttggca  atagttgct  2820
atgtagcaa  tgtcatgga  taatcataa  atattttgc  caaaatttc  atgttgaac  2880
tgcactcac  gttgttaaa  tataaatca  agcttctag  taggccaaa  tatttacat  2940
ctctactaa  cttcaaaat  aatgtatcc  ggaattc  2977



<210> 3866
<211> 484
<212> PRT
<213> Rattus norvegicus
<308> P30839
<400> 3866

Met Glu Arg Gln Val Gln Arg Leu Arg Gln Thr Phe Arg Ser Gly Arg 
  1               5                  10                  15
Ser Arg Pro Leu Arg Phe Arg Leu Gln Gln Leu Glu Ala Leu Arg Arg 
             20                  25                  30
Met Val Gln Glu Arg Glu Lys Asp Ile Leu Ala Ala Ile Ala Ala Asp 
         35                  40                  45
Leu Ser Lys Ser Glu Leu Asn Ala Tyr Ser His Glu Val Ile Thr Ile 
     50                  55                  60
Leu Gly Glu Ile Asp Phe Met Leu Gly Asn Leu Pro Glu Leu Ala Ser 
 65                  70                  75                  80
Ala Arg Pro Ala Lys Lys Asn Leu Leu Thr Met Met Asp Glu Ala Tyr 
                 85                  90                  95
Val Gln Pro Glu Pro Leu Gly Val Val Leu Ile Ile Gly Ala Trp Asn 
             100                105                110
Tyr Pro Phe Val Leu Thr Leu Gln Pro Leu Val Gly Ala Ile Ala Ala 
         115                120                125
Gly Asn Ala Ala Ile Val Lys Pro Ser Glu Leu Ser Glu Asn Thr Ala 
     130                135                140
Lys Ile Leu Ala Glu Leu Leu Pro Gln Tyr Leu Asp Gln Asp Leu Tyr 
 145                150                155                160
Met Ile Val Asn Gly Gly Val Glu Glu Thr Thr Glu Leu Leu Arg Gln 
                 165                170                175
Arg Phe Asp His Ile Leu Tyr Thr Gly Asn Thr Ala Val Gly Lys Ile 
             180                185                190
Val Met Glu Ala Ala Ala Lys His Leu Thr Pro Val Thr Leu Glu Leu 
         195                200                205
Gly Gly Lys Ser Pro Cys Tyr Ile Asp Arg Asp Cys Asp Leu Asp Val 
     210                215                220
Ala Cys Arg Arg Ile Thr Trp Gly Lys Tyr Met Asn Cys Gly Gln Thr 
 225                230                235                240
Cys Ile Ala Pro Asp Tyr Ile Leu Cys Glu Ala Ser Ser Gln Asp Gln 
                 245                250                255
Ile Val Gln Lys Ile Lys Asp Thr Val Lys Asp Phe Tyr Gly Glu Asn 
             260                265                270
Val Lys Ala Ser Pro Asp Tyr Glu Arg Ile Ile Asn Leu Arg His Phe 
         275                280                285
Lys Arg Ile Lys Ser Leu Leu Glu Gly Gln Lys Ile Ala Phe Gly Gly 
     290                295                300
Glu Thr Asp Glu Ala Thr Arg Tyr Ile Ala Pro Thr Ile Leu Thr Asp 
 305                310                315                320
Val Asp Pro Asn Ser Lys Val Met Gln Glu Glu Ile Phe Gly Pro Ile 
                 325                330                335
Leu Pro Ile Val Ser Val Lys Asn Val Glu Glu Ala Ile Asn Phe Ile 
             340                345                350
Asn Asp Arg Glu Lys Pro Leu Ala Leu Tyr Ile Phe Ser His Asn Asn 
         355                360                365
Lys Leu Ile Lys Arg Val Ile Asp Glu Thr Ser Ser Gly Gly Val Thr 
     370                375                380
Gly Asn Asp Val Ile Met His Phe Thr Val Asn Ser Leu Pro Phe Gly 
 385                390                395                400
Gly Val Gly Ala Ser Gly Met Gly Ala Tyr His Gly Lys Tyr Ser Phe 
                 405                410                415
Asp Thr Phe Ser His Gln Arg Pro Cys Leu Leu Lys Gly Leu Lys Gly 
             420                425                430
Glu Ser Val Asn Lys Leu Arg Tyr Pro Pro Asn Ser Glu Ser Lys Val 
         435                440                445
Ser Trp Ser Lys Phe Phe Leu Leu Lys Gln Phe Asn Lys Gly Arg Leu 
     450                455                460
Gln Leu Leu Leu Leu Val Cys Leu Val Ala Val Ala Ala Val Ile Val 
 465                470                475                480
Lys Asp Gln Leu 
                 485



<210> 3867
<211> 1836
<212> DNA
<213> Rattus norvegicus
<308> M73808
<400> 3867

ctcgagacc  cgtccccct  ccagtggac  ccaagtgcg  ttgcgcggt  acagccgcc  60
gcacttgtg  catttcccc  ttcttccga  ccacctttc  cccctccct  ccttcccta  120
ccccttccc  gccctgctt  cctcccttc  ccctagact  ttcgttgtg  tcttcccgt  180
cctgatcct  cccctaccc  acccccaat  cccaggacc  tggcgcccc  gccgcaggt  240
ctgcgccca  gggagccac  atgtgcgtc  tctcagaac  tgtgggcct  cttgccctc  300
ctgccctcc  tttcctcct  gcaggcccc  acatccttc  gaatgacgt  ggacgtggg  360
ccagaggat  aactcccag  ctgggctgc  gccaaagag  tttaccaga  gtatgaccc  420
aaggacatc  ttggcagag  agtgagctc  gtggtccgc  gctgtgtcc  tcgagctac  480
ggtgatgag  ttgcagtga  gatcatgga  gtgtcagct  aacggctga  tcttgagca  540
ctggaggag  tgcgggatg  cacacggcg  gagatgcac  tccttcgcc  ggtcgctgg  600
cacccccac  tcatcactc  catcgattc  tacgagtct  ctagcttca  gttcctggt  660
tttgacctg  tgcggaaag  agagctgtt  gactatctc  cagagaaag  ggccctctc  720
gaaaaggaa  ccaggtcca  tatgaggtc  ctgctggag  cggtgaact  tcttcatgt  780
aacaacatt  tacatcgag  cctgaagcc  gagaatatc  tcctagatg  caatatgca  840
atccgcctt  cagattttg  gttctcctg  catttggaa  ctggcgaga  gcttcgaga  900
ctgtgtggg  ctccgggat  tctagcacc  gagatcctt  aatgctcca  ggatgaaac  960
cacccaggc  acggcaagg  agtcgacct  tgggcttgt  gggtaatcc  gttcacact  1020
ctggctggc  cgccaccat  ctggcatcg  cgccaaatc  tgatgctac  catgatcat  1080
gaaggccaa  atcagttta  ttcacccga  tgggatgat  gttcaaaca  cgtcaaaga  1140
ctgatcgca  agctgctgc  ggtggatcc  aacgcacgc  tgaccgctg  gcaagccct  1200
cagcacccc  tctttgagc  ctgtaaagg  agccagccc  ggaacctca  acctcgcca  1260
cggttccgg  tggcagtgt  gacaatact  gctgctgga  gagtagcct  aagcagtca  1320
cgtttacgg  cactaacta  gaatgcact  ttgagagac  cctatgcac  gcggccagt  1380
cggcgcctc  ttgacaact  tgccttccg  ctctatgga  actgggtga  gaaggggga  1440
cagcagaac  gggcggccc  cttccagca  cagcctcct  ggcctttcc  catcattgc  1500
actgacctg  aaggagact  cagtgctat  acagaggat  aagttacct  ggtacggag  1560
taggacctt  tccctgggc  agccacgaa  taggactcc  caggaggag  ttttctttt  1620
ctatcattc  aaccacttg  gactcagat  ttagccctg  cttgccaag  ctacaactg  1680
gaatgctgc  tgtcacaga  accagccct  tacccctac  tacctactc  ggacttgga  1740
atcggggcg  agatggaag  gaacctctt  ccagcattg  gcctggcct  gccatcacc  1800
cctgtgctg  atctgaaat  aaacctgct  caagcc  1836



<210> 3868
<211> 406
<212> PRT
<213> Rattus norvegicus
<308> P31325
<400> 3868

Met Thr Leu Asp Val Gly Pro Glu Asp Glu Leu Pro Asp Trp Ala Ala 
  1               5                  10                  15
Ala Lys Glu Phe Tyr Gln Lys Tyr Asp Pro Lys Asp Ile Ile Gly Arg 
             20                  25                  30
Gly Val Ser Ser Val Val Arg Arg Cys Val His Arg Ala Thr Gly Asp 
         35                  40                  45
Glu Phe Ala Val Lys Ile Met Glu Val Ser Ala Glu Arg Leu Ser Leu 
     50                  55                  60
Glu Gln Leu Glu Glu Val Arg Asp Ala Thr Arg Arg Glu Met His Ile 
 65                  70                  75                  80
Leu Arg Gln Val Ala Gly His Pro His Ile Ile Thr Leu Ile Asp Ser 
                 85                  90                  95
Tyr Glu Ser Ser Ser Phe Met Phe Leu Val Phe Asp Leu Met Arg Lys 
             100                105                110
Gly Glu Leu Phe Asp Tyr Leu Thr Glu Lys Val Ala Leu Ser Glu Lys 
         115                120                125
Glu Thr Arg Ser Ile Met Arg Ser Leu Leu Glu Ala Val Asn Phe Leu 
     130                135                140
His Val Asn Asn Ile Val His Arg Asp Leu Lys Pro Glu Asn Ile Leu 
 145                150                155                160
Leu Asp Asp Asn Met Gln Ile Arg Leu Ser Asp Phe Gly Phe Ser Cys 
                 165                170                175
His Leu Glu Pro Gly Glu Lys Leu Arg Glu Leu Cys Gly Thr Pro Gly 
             180                185                190
Tyr Leu Ala Pro Glu Ile Leu Lys Cys Ser Met Asp Glu Thr His Pro 
         195                200                205
Gly Tyr Gly Lys Glu Val Asp Leu Trp Ala Cys Gly Val Ile Leu Phe 
     210                215                220
Thr Leu Leu Ala Gly Ser Pro Pro Phe Trp His Arg Arg Gln Ile Leu 
 225                230                235                240
Met Leu Arg Met Ile Met Glu Gly Gln Tyr Gln Phe Ser Ser Pro Glu 
                 245                250                255
Trp Asp Asp Arg Ser Asn Thr Val Lys Asp Leu Ile Ala Lys Leu Leu 
             260                265                270
Gln Val Asp Pro Asn Ala Arg Leu Thr Ala Glu Gln Ala Leu Gln His 
         275                280                285
Pro Phe Phe Glu Arg Cys Lys Gly Ser Gln Pro Trp Asn Leu Thr Pro 
     290                295                300
Arg Gln Arg Phe Arg Val Ala Val Trp Thr Ile Leu Ala Ala Gly Arg 
 305                310                315                320
Val Ala Leu Ser Ser His Arg Leu Arg Pro Leu Thr Lys Asn Ala Leu 
                 325                330                335
Leu Arg Asp Pro Tyr Ala Leu Arg Pro Val Arg Arg Leu Ile Asp Asn 
             340                345                350
Cys Ala Phe Arg Leu Tyr Gly His Trp Val Lys Lys Gly Glu Gln Gln 
         355                360                365
Asn Arg Ala Ala Leu Phe Gln His Gln Pro Pro Arg Pro Phe Pro Ile 
     370                375                380
Ile Ala Thr Asp Leu Glu Gly Asp Ser Ser Ala Ile Thr Glu Asp Glu 
 385                390                395                400
Val Thr Leu Val Arg Ser 
                 405



<210> 3869
<211> 1377
<212> DNA
<213> Homo sapiens
<308> NM_006213
<400> 3869

ggccttcag  cctctgtgg  cccctctcc  cggggggct  tgggattct  gtcaagctc  60
ttcaagagc  tgcaagcac  taaccagcc  cccagagtt  cctcactga  gatctgagc  120
tgacccggg  cgaggcact  ccggactct  attctgcac  ggacttcta  gagaattat  180
agcccaaag  gatcctggg  aggggcgtt  gcagtgtgg  caggcgatg  atccacaag  240
ccacgagcc  ggagtacgc  gtgaaggtc  tcgacgtca  cggtggagg  agcttcagc  300
cggaggagg  gcgggagct  cgagaagcc  cgctgaagg  ggtggacat  ctgcgcaag  360
tctcagggc  ccccaacat  atacagctg  aggacactt  tgagaccaa  actttcttc  420
tcttggtgt  tgacctgat  aagagaggg  agctctttg  ctacctcac  gagaaggtc  480
ccttgagtg  gaaggaaac  agaaagatc  tgcgagctc  gctggaggt  atctgcacc  540
tgcacaaac  caacatcgt  caccgggac  tgaagcccg  gaacattct  ttggatgac  600
acatgaaca  caagctcac  gactttggc  tttcctgcc  gctggagcc  ggagagagg  660
tgcgagagg  ctgcgggac  cccagttac  tggcccctg  gattatcga  tgctccatg  720
atgaggacc  cccgggcta  gggaaagag  tggacatgt  gagcactgg  gtcatcatg  780
acacgctgc  ggccggctc  ccgcccttc  ggcaccgga  gcagatgct  atgctgagg  840
tgatcatga  cggcaacta  cagtttggc  cgcccgagt  ggatgatta  tcggacacc  900
tgaaggacc  ggtctcccg  ttcctggtg  tgcaacccc  gaaccgcta  acagcggaa  960
aggccttgg  acacccctt  ttccagcag  acttggtgg  ggaagtgcg  cacttcagc  1020
cccggggga  gttcaaggt  atcgctctg  ccgtgctgg  ttcagtgcg  atctactac  1080
agtaccgcc  ggtgaagcc  gtgacccgg  agatcgtca  ccgagaccc  tatgccctc  1140
ggcctctgc  ccggctcat  gacgcctac  ctttccgaa  ctatggcca  tgggtgaag  1200
aggggcagc  gcagaaccg  gcagccctt  tcgagaaca  acccaaggc  gtgctcctc  1260
ccctggccg  ggaggacta  tgaggggct  gccagtcag  gagggctag  gggcaggtg  1320
ggaggggaa  ccatggaaa  acaagtcaa  ggggtaaaa  aaaaaaaaa  aaaaaaa  1377



<210> 3870
<211> 386
<212> PRT
<213> Homo sapiens
<308> Q16816
<400> 3870

Thr Arg Asp Glu Ala Leu Pro Asp Ser His Ser Ala Gln Asp Phe Tyr 
  1               5                  10                  15
Glu Asn Tyr Glu Pro Lys Glu Ile Leu Gly Arg Gly Val Ser Ser Val 
             20                  25                  30
Val Arg Arg Cys Ile His Lys Pro Thr Ser Gln Glu Tyr Ala Val Lys 
         35                  40                  45
Val Ile Asp Val Thr Gly Gly Gly Ser Phe Ser Pro Glu Glu Val Arg 
     50                  55                  60
Glu Leu Arg Glu Ala Thr Leu Lys Glu Val Asp Ile Leu Arg Lys Val 
 65                  70                  75                  80
Ser Gly His Pro Asn Ile Ile Gln Leu Lys Asp Thr Tyr Glu Thr Asn 
                 85                  90                  95
Thr Phe Phe Phe Leu Val Phe Asp Leu Met Lys Arg Gly Glu Leu Phe 
             100                105                110
Asp Tyr Leu Thr Glu Lys Val Thr Leu Ser Glu Lys Glu Thr Arg Lys 
         115                120                125
Ile Met Arg Ala Leu Leu Glu Val Ile Cys Thr Leu His Lys Leu Asn 
     130                135                140
Ile Val His Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp Asp Asn 
 145                150                155                160
Met Asn Ile Lys Leu Thr Asp Phe Gly Phe Ser Cys Gln Leu Glu Pro 
                 165                170                175
Gly Glu Arg Leu Arg Glu Val Cys Gly Thr Pro Ser Tyr Leu Ala Pro 
             180                185                190
Glu Ile Ile Glu Cys Ser Met Asn Glu Asp His Pro Gly Tyr Gly Lys 
         195                200                205
Glu Val Asp Met Trp Ser Thr Gly Val Ile Met Tyr Thr Leu Leu Ala 
     210                215                220
Gly Ser Pro Pro Phe Trp His Arg Lys Gln Met Leu Met Leu Arg Met 
 225                230                235                240
Ile Met Ser Gly Asn Tyr Gln Phe Gly Ser Pro Glu Trp Asp Asp Tyr 
                 245                250                255
Ser Asp Thr Val Lys Asp Leu Val Ser Arg Phe Leu Val Val Gln Pro 
             260                265                270
Gln Asn Arg Tyr Thr Ala Glu Glu Ala Leu Ala His Pro Phe Phe Gln 
         275                280                285
Gln Tyr Leu Val Glu Glu Val Arg His Phe Ser Pro Arg Gly Lys Phe 
     290                295                300
Lys Val Ile Ala Leu Thr Val Leu Ala Ser Val Arg Ile Tyr Tyr Gln 
 305                310                315                320
Tyr Arg Arg Val Lys Pro Val Thr Arg Glu Ile Val Ile Arg Asp Pro 
                 325                330                335
Tyr Ala Leu Arg Pro Leu Arg Arg Leu Ile Asp Ala Tyr Ala Phe Arg 
             340                345                350
Ile Tyr Gly His Trp Val Lys Lys Gly Gln Gln Gln Asn Arg Ala Ala 
         355                360                365
Leu Phe Glu Asn Thr Pro Lys Ala Val Leu Leu Ser Leu Ala Glu Glu 
     370                375                380
Asp Tyr 
 385



<210> 3871
<211> 2507
<212> DNA
<213> Rattus norvegicus
<308> M74223
<400> 3871

gagcgagag  gctgttgct  acccagctg  gcccagctc  taggacgcc  gccctcgac  60
atctttcat  ctccagcca  ggaacggag  cagggcaga  gggtccgga  tttccccct  120
ccccgaccc  cctctccac  tcccgccgt  gtgacaccg  ctgtctctg  cagcccgtt  180
gtcatgaaa  ccttcacgt  gccagcatc  gtcctcttc  gcttccttc  actcatccg  240
gggttggga  cagcacccc  cgggcgctc  gatgtttat  ctcctcccc  cggctctga  300
cataatggg  aggtagctg  ggacgcagt  tcccggcca  aggatgaca  cgtcccaga  360
gtccgagcg  ctcggaatt  cgagcctca  gaccaggga  agctcttcc  gggcgtgga  420
ccccgggcg  tggccgcgg  actgttgca  gcactggac  gtccggcct  gcccccggc  480
gtcccggca  gttcccagc  gggaacacc  gaagaagca  cagaagctc  gctgaccga  540
tccgtgcgc  gtcagaccc  tagcctccc  gcatcagaa  tccaagcgt  cgctgtggc  600
ccccctcgc  ctcagactc  ggacaacga  cccgaggca  acgaccgct  agaagagct  660
gaggcacta  catccttgc  ccaagaact  cgagatttc  gtccgagta  tgctaagcg  720
cagcaagag  cggcggcag  agagactga  acccgcacg  acacgctga  ccgagtcaa  780
ctggagagc  ccgggccag  gcgcgtatg  cgcgcttcc  ggggagagt  ccaggcgcg  840
gtcccggag  gtgctcctc  gccgccctc  gtcccttct  aattccagg  tcgaatgtc  900
gaaaacgtt  cccttcccg  aacccatca  ttcggggaa  gagtgtcct  ccctaaaac  960
catcttggt  agactttga  acccttatc  aaggcgtac  aaagtctaa  tgccccctt  1020
cccaaggtg  gtcggctcg  gggctcatt  ctgggcggt  ccgaggcag  agagcgcct  1080
cttcaacaa  ggttagctc  ggtagaggc  gggaggagg  aggcggagg  cacccggca  1140
gccgcagcg  aagaagagc  gctggccga  ctcgcctcc  acctgctgc  ccagtattt  1200
ctgcagggc  gcgcccggc  gcgcgatct  gggggtcgc  ggctgcagg  gacgcagca  1260
gagcgggag  acgagaggg  ggaggaggc  gagcaggag  gacgcggtg  tggggagga  1320
gaggtgggg  aagaggatg  ggaggcggc  gaggcggag  cggaggcag  ggaggcgga  1380
agggcgcgg  agaacgcgc  cctgttcgc  gaggaggag  acggggaag  cggagccga  1440
gacaagcgc  cccaggagg  ggcgccagg  catcggcgg  aggatgctg  ggggacaga  1500
gagggcggg  aggaggatg  cgacgacga  gagatggat  cgcagacga  cgatagtct  1560
attgaactg  ccaccaaac  ccacctgcc  gcagacgat  tggtcagca  catcgaaga  1620
gtggaggag  aacggaagc  gaagaagaa  gcccctccc  agccggtgc  accccccag  1680
gctgcccca  ccccgaccc  tgtccgctc  ccgcagccc  cacctcccg  cccggcccg  1740
gatgagttg  cggactgga  cgaagtact  ccaccctgg  atcgggagg  ggatgaggt  1800
tttcccccg  ggccctatc  ccccttccc  aactacatt  ggccgcgga  actgcagcc  1860
cccgcatcc  cccgccgcc  tcacttcca  cacgcgttg  cacctgcgc  ccaccatcc  1920
gatctggag  cccaggcca  gcgcgcgca  gaggaagcg  acgcggagg  gcgccggct  1980
caggagcag  aggagctgg  gaattacat  gagcacgtg  tgctgcacc  cccgtgacc  2040
gcccctgcg  gcccgctcc  aactgcgcg  gccgccacg  ccccctccg  gtcgctcct  2100
ctccctctc  gtgtttgca  gcgccccgg  tccgcccct  ggctgccgc  cggccccgc  2160
ccacaaggc  ccgccccgg  ttctgtcag  accagacct  tcagacttc  ttggggtct  2220
atcctgggg  cagcccagg  gggtgtgtg  tttgtgcga  tccccttac  cccccactt  2280
ctccagggg  ctcgtcccc  tctagtttc  ctagcgact  cctggtccc  aacggggaa  2340
agctgttct  tttaatcgt  tgaagtgtc  gtctcccag  cttggggcc  ccggagcct  2400
ccttctcca  attgctgtg  acttaccca  atcttgccc  tctgttgta  atacccctc  2460
cggaggaaa  agttttgct  agaaataaa  gtgactatt  tattagg  2507



<210> 3872
<211> 617
<212> PRT
<213> Rattus norvegicus
<308> P20156
<400> 3872

Met Lys Thr Phe Thr Leu Pro Ala Ser Val Leu Phe Cys Phe Leu Leu 
  1               5                  10                  15
Leu Ile Arg Gly Leu Gly Ala Ala Pro Pro Gly Arg Ser Asp Val Tyr 
             20                  25                  30
Pro Pro Pro Leu Gly Ser Glu His Asn Gly Gln Val Ala Glu Asp Ala 
         35                  40                  45
Val Ser Arg Pro Lys Asp Asp Ser Val Pro Glu Val Arg Ala Ala Arg 
     50                  55                  60
Asn Ser Glu Pro Gln Asp Gln Gly Glu Leu Phe Gln Gly Val Asp Pro 
 65                  70                  75                  80
Arg Ala Leu Ala Ala Val Leu Leu Gln Ala Leu Asp Arg Pro Ala Ser 
                 85                  90                  95
Pro Pro Ala Val Pro Ala Gly Ser Gln Gln Gly Thr Pro Glu Glu Ala 
             100                105                110
Ala Glu Ala Leu Leu Thr Glu Ser Val Arg Ser Gln Thr His Ser Leu 
         115                120                125
Pro Ala Ser Glu Ile Gln Ala Ser Ala Val Ala Pro Pro Arg Pro Gln 
     130                135                140
Thr Gln Asp Asn Asp Pro Glu Ala Asp Asp Arg Ser Glu Glu Leu Glu 
 145                150                155                160
Ala Leu Ala Ser Leu Leu Gln Glu Leu Arg Asp Phe Ser Pro Ser Asn 
                 165                170                175
Ala Lys Arg Gln Gln Glu Thr Ala Ala Ala Glu Thr Glu Thr Arg Thr 
             180                185                190
His Thr Leu Thr Arg Val Asn Leu Glu Ser Pro Gly Pro Glu Arg Val 
         195                200                205
Trp Arg Ala Ser Trp Gly Glu Phe Gln Ala Arg Val Pro Glu Arg Ala 
     210                215                220
Pro Leu Pro Pro Ser Val Pro Ser Gln Phe Gln Ala Arg Met Ser Glu 
 225                230                235                240
Asn Val Pro Leu Pro Glu Thr His Gln Phe Gly Glu Gly Val Ser Ser 
                 245                250                255
Pro Lys Thr His Leu Gly Glu Thr Leu Thr Pro Leu Ser Lys Ala Tyr 
             260                265                270
Gln Ser Leu Ser Ala Pro Phe Pro Lys Val Arg Arg Leu Glu Gly Ser 
         275                280                285
Phe Leu Gly Gly Ser Glu Ala Gly Glu Arg Leu Leu Gln Gln Gly Leu 
     290                295                300
Ala Gln Val Glu Ala Gly Arg Arg Gln Ala Glu Ala Thr Arg Gln Ala 
 305                310                315                320
Ala Ala Gln Glu Glu Arg Leu Ala Asp Leu Ala Ser Asp Leu Leu Leu 
                 325                330                335
Gln Tyr Leu Leu Gln Ala Gly Ala Arg Gln Arg Asp Leu Gly Gly Arg 
             340                345                350
Gly Leu Gln Glu Thr Gln Gln Glu Arg Glu Asn Glu Arg Glu Glu Glu 
         355                360                365
Ala Glu Gln Glu Arg Arg Gly Gly Gly Glu Asp Glu Val Gly Glu Glu 
     370                375                380
Asp Glu Glu Ala Ala Glu Ala Glu Ala Glu Ala Glu Glu Ala Glu Arg 
 385                390                395                400
Ala Arg Gln Asn Ala Leu Leu Phe Ala Glu Glu Glu Asp Gly Glu Ala 
                 405                410                415
Gly Ala Glu Asp Lys Arg Ser Gln Glu Glu Ala Pro Gly His Arg Arg 
             420                425                430
Lys Asp Ala Glu Gly Thr Glu Glu Gly Gly Glu Glu Asp Asp Asp Asp 
         435                440                445
Glu Glu Met Asp Pro Gln Thr Ile Asp Ser Leu Ile Glu Leu Ser Thr 
     450                455                460
Lys Leu His Leu Pro Ala Asp Asp Val Val Ser Ile Ile Glu Glu Val 
 465                470                475                480
Glu Glu Lys Arg Lys Arg Lys Lys Asn Ala Pro Pro Glu Pro Val Pro 
                 485                490                495
Pro Pro Arg Ala Ala Pro Ala Pro Thr His Val Arg Ser Pro Gln Pro 
             500                505                510
Pro Pro Pro Ala Pro Ala Arg Asp Glu Leu Pro Asp Trp Asn Glu Val 
         515                520                525
Leu Pro Pro Trp Asp Arg Glu Glu Asp Glu Val Phe Pro Pro Gly Pro 
     530                535                540
Tyr His Pro Phe Pro Asn Tyr Ile Arg Pro Arg Thr Leu Gln Pro Pro 
 545                550                555                560
Ala Ser Ser Arg Arg Arg His Phe His His Ala Leu Pro Pro Ala Arg 
                 565                570                575
His His Pro Asp Leu Glu Ala Gln Ala Arg Arg Ala Gln Glu Glu Ala 
             580                585                590
Asp Ala Glu Glu Arg Arg Leu Gln Glu Gln Glu Glu Leu Glu Asn Tyr 
         595                600                605
Ile Glu His Val Leu Leu His Arg Pro 
     610                615



<210> 3873
<211> 265
<212> DNA
<213> Homo sapiens
<308> BF223121
<400> 3873

gctaagaaa  aaaagtgac  attttatta  gactttgtt  tcggttatt  acccgtccc  60
ttgggcctg  gtggtcctt  ccaaggggc  gtgagggaa  cgccagcca  agtccccgt  120
tcctcctgc  tcctgcccc  aaactaagg  gaggggtaa  tggggaaag  cctcaaact  180
tttttagag  agaagaatg  ggctcgcac  cattaagaa  cccgaaatt  cacttccag  240
ttgggggct  gtggtaaag  catct  265



<210> 3874
<211> 11728
<212> DNA
<213> Rattus norvegicus
<308> M74439
<400> 3874

ggggagggg  acacacata  agaagagga  agggaggag  tagggggat  ttggcctgg  60
aaccgggaa  gggaataac  attgtatat  agaaatacc  aaattaata  agatggaga  120
aaaagtcat  atttctttt  cctatcacc  tggtatctg  tacttacca  ctttgaagc  180
atgcaagtt  tattttaac  tcttgtata  atcttttcg  ataaaagat  aagcagtga  240
agaagggaa  actgtgacc  gaaggactt  gatgttcaa  atgcccaga  agtggattt  300
tgctctgtt  ctgctacag  taagttact  tttcaaatc  gggcactgt  ggaaggtgt  360
ggtgtggcc  atggacttt  gtcactgga  gaatataaa  ataatcctt  atgaacttg  420
acagagggg  catgaggtc  ctgttctga  accttcggc  tactttttt  ttgatccga  480
aaaatcgtc  gaccttaag  ttgaaattt  ttctacatc  atcagtaaa  atgagctgc  540
aaatcattt  ataaaactt  tggatgtgt  gacttatga  ttgccaaga  atacatgtt  600
gtcatattc  cctatcctt  aaaatctag  ttatgaatt  tcttatttt  atctaagta  660
ttgtaaaga  gctgtttca  acaagcagc  catgacaaa  ctacaggaa  ccaagtttg  720
tgttctttt  gcagatcct  tggcttcct  tggggatct  atagctgaa  tgctccaca  780
tccttttct  tacagtctt  gcttctctc  aggccacaa  cttgaaaag  ccattggaa  840
atttatact  cctccatct  atgtgcctg  aattttgtc  ggactggct  gcaaaatga  900
attcataga  agggtaaaa  atatgatat  tatgcttta  ttcgacttt  ggttcgaga  960
acttagaca  aaggaatgg  acacgtttt  cagtgagat  ttgggtaag  tacattttg  1020
tcagtagac  gaaacctaa  tttcacatg  gtgtaagac  tatgtccat  aaatacaaa  1080
tgaagtaat  ttttatagg  gatcaaatg  ataatgata  cagccatcc  agtcacaac  1140
tcttgtaaa  gctcatgta  ttcatcaaa  ggaagaagg  aactcttct  atacaagac  1200
ttttggtta  ctatacctg  gcatagaga  gaactagat  gtctctggg  gattcttta  1260
tcatcctgt  ttttagtaa  tttctaagc  gttagcaaa  cttgtttca  gaaggttca  1320
gaatgatat  tttcacagt  tcaatatgt  tataaacat  gaagaaatt  ttttctttt  1380
cctaggcca  tgtcttcat  taaaatgaa  atgtagggt  cgaaaacat  gacaaaggg  1440
tgagattgt  tctatacag  ttagtacct  agctctctt  ccagtatca  tcatttcca  1500
tggcagaaa  ctgcctata  cttcagttt  aagagaaat  ctgcccttt  atgatccac  1560
ggcactggt  taaacttaa  ctatgctct  gcagatatg  atacaaata  atgaaaaga  1620
agatcataa  atattttct  tatttattt  tttaaaatt  ccctaatct  ggaagctat  1680
ttggtattt  ccaagttta  aagtgccac  gatgtttct  ccagtccca  atttttttt  1740
tgagtccct  ccaaaattc  attgcaaat  gctaaattc  acagaagca  ggacacacg  1800
gctgaagtt  ttgaagtca  gtccttatt  ctcttgaaa  tatctgaca  ctaaactag  1860
ccaaaattc  tattatttt  tttttatta  taaattgag  atttcttat  ttcattttg  1920
gtgttattc  ctttcccgg  atccggcaa  cggggcccc  ccctcttct  ccttatggg  1980
gttcccctc  cgaccctcc  cccattgcc  ccctccccc  accagtcta  ttcattggg  2040
gtacagtct  agcaggacc  agggcttct  cttccactg  tgctcttac  aggatattc  2100
ttgctacct  tgaggtcag  gtccagggt  agtccattt  tagtcttta  gtagcggct  2160
agtccctgg  agctctggt  gctttagca  tgttgtaca  atggggtct  gagcccctt  2220
aaatatgat  tataaatca  tttttgata  aagttatat  atacattaa  atattacat  2280
ttacatgca  atgttctac  taaaacata  attcttcca  cattttaag  aaatagatt  2340
atactcagc  gacagttct  tcaaatttt  tctgtctct  atttgctca  tttccctat  2400
taggaaggc  caccaccgt  gatgagaca  tgagcaaag  agaaatatg  cttattaga  2460
cctattggg  tttgaaatt  ccccaccca  cattaccaa  tgttgacta  attggagga  2520
tccattgca  acctgctaa  cccttgcct  aggtaaata  attcttttt  tgtttttca  2580
ttcatatca  ttcggatga  atgttctac  tctttcatt  cattcttct  ccactaata  2640
agatatgtg  gaagtggaa  taaaagtcc  gctaaatgg  agctaaata  acccagaaa  2700
gaggatgac  gacataaaa  aatatatca  tgagttaag  catgtaggc  attggagtg  2760
ttagcaatt  ggtaaagtt  tttaccaag  aaccataag  aaatgagtt  gaattcaat  2820
ctgttagat  aaaaatgta  ttctgttac  aatttacca  tagttcaca  aatatattt  2880
cattcgtta  ctttcaatt  accagagga  aacattgag  acatttgtt  aacaagtat  2940
agtatacta  atactgctg  ctgtgtttt  ccatgccag  tctgtcttt  gtatgtttt  3000
tatgattct  tacattcct  agaatactt  aatttttat  ttcctagag  tcttttgta  3060
agctttcat  agtgattgt  ctacaattg  tattgtgtg  ccgagaaat  atttattca  3120
aggatatgg  agaatttgt  cagagctct  gagagcacg  tgtggtggt  ttttctctg  3180
ggtcaatgg  cagcaacat  acagaagaa  aggccaacg  aattgcatg  gcccttgcc  3240
agattccac  aaaggtgag  taaagtgcc  atgggaggt  actgtaaac  gagactgta  3300
aagtactca  aaagtctga  tctaacagt  attgtgtga  acctaaagg  ttagctaat  3360
tctaattta  caagccaaa  tacaaacag  aacacacaa  agatgtcac  atacagagg  3420
tatttttga  tacaagtgc  ttgaatatc  atcttgtga  ttctgtagg  acattctga  3480
atggtggca  tctgatgac  agggtcatg  ctgtgaagg  cataggttg  tatagaaaa  3540
ttcttcttg  tttctcata  aatgataat  gttgcagcc  attgttagt  cttgtgaac  3600
aaaaccaac  tgtacagaa  ttgtgcaac  gaaaacaca  caaatctaa  acaaccctt  3660
actagtgga  gaccacaca  gggaaaata  ttggaaagg  caaatggct  cttaaaatt  3720
attgtttga  tttaatttt  atgataaaa  catacatag  taatactgc  caggtcaaa  3780
taatacatt  ggctttcac  atgcactgg  aatttattg  agtatttaa  acaaacccg  3840
tgtggagct  cttcccaga  actgtgact  gacacaatt  catactgta  ctcaggtta  3900
tggcttcaa  agccagaaa  tctccattc  tcagactcc  gaggtagga  gatagatga  3960
ttttaagaa  ttaaatagt  gggtgggta  ggaagaggg  gatttagtg  agattgggg  4020
aaggaggga  gaataagaa  aaaacatta  atgaaactc  tagggaaat  aaaaaagag  4080
tatcaatgt  aatgtgtgg  cctagtaat  atttggagt  caggtatgc  gatgatgcc  4140
acatgctct  aacctttgg  ccacagcaa  tgctcttca  agggttgca  gtctatgtt  4200
ttgtaaaaa  ataaaataa  tggtccaat  gtcttttac  ctgcttggt  cgcaccacg  4260
tccccaaga  atcttctag  tatcttggt  gaaacacat  ccagccaca  tttcctaaa  4320
tcaaacccc  acataaaag  acatacaac  caataatct  agatccaat  gtaagatat  4380
attcccact  aaacataca  agcccagta  catccatcc  ttgagaaca  taataacaa  4440
ctgtaaata  acagagcag  atcataaca  cacctgcca  ggcttctcc  ctctctcca  4500
ctcctcttc  cctcctctc  cccttagtc  cctcctctt  cttcaaaca  ctctcccgc  4560
catccatcc  tctcctcca  tgacaggcc  ccttctatc  tgtagctgc  tcacctgtg  4620
catcatcct  tatttcacc  ttttgtcta  ttaaaaaaa  cttttctct  aaatataag  4680
tgagcacaa  tactatcat  ttgtaatta  gagcataaa  tatatctaa  accagtcca  4740
cactatatc  gttaaacag  acatttagt  atccattcc  gcttgagaa  agcttaaaa  4800
ctgtattat  tcttggcta  cttgtatac  acctgataa  tatccaata  aatatgtat  4860
tttagcgtt  aacagcctg  taggctatg  gactatgtc  tcaaccctg  cagaaatct  4920
ggaatgacc  aatatctat  cacatagga  gcctaacac  gcttccaga  ctgagaggt  4980
gtagagaca  atctccact  gcacagtcc  ctgttagca  catgtgagc  caagccttc  5040
ggcccaaaa  caactgaca  actctagaa  tgcagattt  aaagggctg  tcaccctgt  5100
ttggcagag  ttatcagtc  actatttgc  taatttgtc  atttctgga  agtattagt  5160
tgcagatga  acaggcagt  ttgtgtagt  gctgcctag  cacaaagta  tgcatcacc  5220
ggaggtaga  atgttcaca  tcttcatta  atccaccaa  ggggaactg  taggagcag  5280
catgtctca  caaaagata  ataacttta  atctcaatt  tgtggattt  tgacgtttt  5340
taaaaccat  tacttatat  agacaatat  tactcttgt  tttatatct  aataatatc  5400
tgaaagttc  ctcacaaag  cagtaatat  tttgctatt  ggcccttaa  tcacatgtg  5460
aatcaactc  gatgtttgt  atgacatca  tagaaggac  ggctctaaa  cttgtactt  5520
taaactctt  tgacaaata  attctatac  aaagcaaag  tatgatttc  gcttagtta  5580
caaatgaga  tatgactgt  gctactcac  caactccat  cctggacca  tccaacact  5640
caatatgga  gggttcttc  agatgagtt  gatgactcc  tagtcctat  atccaacac  5700
ttggctatt  attccaagt  ctcatgggc  aagagattt  tgaatggga  acaaaaatc  5760
atgacacac  atcaatgac  aaaaaattg  aattcaagt  agattacat  aaataagtg  5820
acaaatata  aactccaca  tgtttaaaa  gtagtttta  tacaatatt  agactggaa  5880
attagagat  tcaaaatca  ttagatgaa  taaattatt  aaaatttgc  aatactctt  5940
gcagatgaa  tatgtcacc  tggcaacgt  ctaatattt  cctgtatca  taactgtct  6000
atttgtcta  acatttctt  ctcaaaagt  gagattatg  ttacctgtg  gagtgtaac  6060
caaaaaatg  tgacactat  gtgtgagtc  tctgagttc  cagtactta  tgcttctga  6120
cctctcatc  atccatggg  ggtattcag  gcagttttc  ctatcctta  aaaaatgct  6180
cattttaaa  ttgtttctc  tttagaaat  ataattata  catttctgc  tttccattc  6240
tcctttcaa  cactcccat  aacgtgccc  cttggtctt  ttcaaatac  ccgagctct  6300
ttttccatt  cttgttaca  acacatatt  atgtctcta  acttatatt  ctaaatata  6360
cctgctctg  ctttataat  ttaaatatg  ctgcagtca  caaaattgt  taacattta  6420
caggttctt  ggaaatttg  tggcaaaac  ccagcaaca  taggaccca  taccagagt  6480
tacaagtgg  tcccgcaga  tgacctcct  ggtaagtct  tggaaatca  atgcaacat  6540
atgactgag  aactgatta  tgtagctat  tcttttaac  tcaaactct  cgtatcaca  6600
atacttcat  gattattta  ttaagataa  aagttctga  atggatttg  tctttttat  6660
cctcatttc  ttcttcctt  tcttattcc  atctttctc  ttttttaag  caaggggat  6720
ttattctaa  taattattg  taactagaa  caaatatca  actctgatt  ctgcacaca  6780
cttatatga  tatgttggc  atacacata  tttctaaga  gtatagtcc  ataccttat  6840
tactgttaa  agactcaat  ctaacacca  ttccttttt  tttctcctt  tgactttac  6900
ttttaatca  tttgcataa  catgtgttt  ccagtgcct  actctcaac  tgcagattg  6960
taaggttaa  taactccct  ggtttacaa  agaatgatt  ttaatccac  cagagcaac  7020
aaggtcaac  ttaaaacat  gttaaattg  ttattttat  tatttacat  taaagtgtt  7080
ttccccttc  catgttccc  tccacaaag  cactattac  tgatttttt  ttcatacct  7140
tatgtgggt  ctcccacag  ctcctcaaa  actactggc  cagcggcct  gttttcccc  7200
atcttgagt  atcaagcct  cacagactc  atgggattc  ctcaactga  gccagataa  7260
ggcatcctt  ctcaaatat  cagctggag  catggaaca  tctgtttgt  tctttggtt  7320
gtggtttag  ccctgagaa  ttacgaagg  ctggttggt  gatattgtt  ttcttccta  7380
ggggatgta  accccttca  ctccctcac  ctttgccct  acttttcca  aggggtcat  7440
aagctcact  tgatagttg  ctgcaagta  ccatatccg  attggtcag  ctctggaaa  7500
gccttctag  ggacagcta  atcaggttc  tgtcatatc  atggtacct  ggtttgttg  7560
ctgctgagg  gatggatcc  ttggtggag  agactctgg  tgccctttc  ttcagtttc  7620
gctctactc  ttgtccctg  ttttccttt  gacaggagg  attctggtt  aagattttt  7680
aggtgggtg  ttgggccca  ccctcaaac  gaggccttg  ctatccatt  aatatggtc  7740
ctgcagact  tctctcccc  ttgttggtt  tttcagcta  tgtcctcct  tttgttcct  7800
gaaacttct  gagtccctg  aacctggtg  tttctaatg  ctttcacta  ttgcatcta  7860
acacctcaa  tcaaatcct  gccctctgt  catctccct  atatcctcc  atatctgaa  7920
tgccataga  tctttccct  cctctcctt  cctgctcca  gatcctcct  ccctctact  7980
attttgatt  ttttctact  catttgagt  tgactgaaa  atccacatt  gtcttcttg  8040
acttcacat  gtctgtgag  tgtgtcatt  gaattttga  ctttctatg  cttataacc  8100
ctaatcagt  agtacatac  atgtgtgtt  ttttgtgcc  gggttacct  actcaggat  8160
agattttct  gttccttcc  cttcccttc  aatttcaag  agtcatttt  ttaacagct  8220
agtaatatt  cattgtgta  atgtgccac  ttttctgta  gcactcgtc  gttcaggga  8280
atctgggtt  ttatcatct  ctggctatt  taaataaag  tgctatgaa  atagtggag  8340
acagttttt  gttatatgt  gagacatat  ttgggtata  gcccaggag  ggtatagct  8400
tatgctcag  tagcactat  tcatatttt  tgaggaacc  cgaaattga  ttccagaat  8460
gttgtacca  ttggcagtc  caccagcat  ggaggactg  tcctctttc  ccatatcct  8520
accagaaac  gctgtcacc  gagtttttg  tcttaatca  tgggactgg  gtgaggtgg  8580
atctcaggg  cattttgat  tgcattttc  tgacgactg  ggatgttga  catttcttt  8640
agggcttct  acccactca  tcttcctta  ataataatt  tgcttagtt  tatacccca  8700
ttttaaatg  ggttatttt  ttctctgga  ccaagcttt  ttagttctt  gtatatttt  8760
catgttacc  ctctattgg  taggtttgg  aaagatctt  tgacaatct  tgggatttc  8820
attttttca  tcactattt  tatctacta  gacttcata  gttcaacca  aaaagggtt  8880
ttcatacct  aagtctcaa  gccacattc  aatttgcaa  aatacttct  cagaaattt  8940
gtttcttct  gctctgaga  agaaaaata  tttagagat  ttatgattt  atgaatctt  9000
atgtaaaaa  atctccttt  agttcctct  agtatacat  tctctttcc  agtccaaaa  9060
tgctaatca  tgttaatct  aatttatct  cttgtaggt  acccaaaaa  caaagcctt  9120
gtaactcat  gtggagcca  tggcctcta  gaggcaatc  atcatggaa  ccctatgat  9180
ggcattcct  tgtttggag  tcaacctga  aatattgcc  acatggtgg  caaaggagc  9240
gctgtttca  tgaatatca  gacaatgtc  aagttagat  ttctcagtg  actggtgga  9300
gtcatagac  atccgttgt  agtataact  tctataatc  ttcatttat  cattcaatc  9360
atcagtcaa  cacttgctt  ttcatatat  tatacgttc  ttgttttct  accaaagac  9420
aacaaacga  aattatact  atatgaacc  acatatatt  gggcacgat  cagtacaaa  9480
attatactc  cctttactc  ttgttttta  attccttgt  aggccttat  ttattttgc  9540
atttaaatc  tggtagtct  aagtgtgca  cccttctgc  ttaccttcc  cactacttg  9600
ccaagaagt  tttttgaca  ccctggaca  taccccaaa  gaaatcttt  atttcttgt  9660
tgggttttt  tttattaag  attccatgg  tattgaagg  gaatccatc  ggttagatg  9720
gcaaagttc  ttaaaatta  atatgtaca  agacctgga  tagaatgta  ggtataagt  9780
gctaatagt  taattcttt  tttgtcata  attcctgtt  ttattgtct  tatttctct  9840
ctcttctcc  cttcccaat  ccctaatta  atccctcaa  atctgctat  tcccttaac  9900
ctattcaca  agtcttctc  atttacacc  ttcccagtc  ctgaggact  tctactctt  9960
atattcttc  aagagataa  ttgaatctt  aattgtaaa  gactgtaat  tgaatacta  10020
tgaatgagg  tgttttaat  agaagaaag  cacagtttt  ctcttgtgc  ttgaaatta  10080
aaccattgt  attcttacc  gtttttcta  atcaaactg  tatttagga  tggtaactc  10140
ggcctctat  tcaccctct  cttgtgtac  catcaataa  tatttcaac  gtagagtca  10200
atgcacttg  atcatgctt  tttgtgaaa  tccatcaac  tttctagag  cagaatgtt  10260
acaaaaaat  aaggtcagc  ataatatca  aaattaggc  caatgggta  gagcagggt  10320
ttttgtagt  ttcattcca  ccactgatg  caattttat  acttatagc  ataaaaaaa  10380
tgttatgtt  ttgtcaacc  ttcaccatg  ccagcctat  aagcccctg  acagagctg  10440
cttctggat  gagtttatc  tgcgccaca  aggggccaa  cacctgaga  cacttggac  10500
taaccttcc  tggtaccag  accactctc  ggatgtgat  ggattcctg  tcacctgtt  10560
tgcagtcat  gcagctctt  ctgtaaaat  tctcttgtt  atgtaccga  tctttgtaa  10620
gaaggaaaa  aaaatgaag  atgagtaga  ctcattgac  atgcactac  gaaatgaaa  10680
ttcagcgtc  ttctaattt  tgaaccacc  tctaaaaat  actaatttt  tatcaaggt  10740
gataacctt  gtaggaaga  atataactc  gtgaatact  atatgtact  aaaaatcca  10800
catttttaa  ttttaaaac  acttaatgt  aaagttaca  tgtagaaaa  tgtgcagaa  10860
aaaattatt  ttgatagag  ccaaataat  aaagtatta  ccttaaaat  tttgaatag  10920
gtccattag  ttctttgtc  aatactgaa  ctgtagctt  catacaata  aatgtagat  10980
acttgtaca  gataaatac  ggcatataa  tttttttct  taatagacc  aattacttg  11040
tgtctggga  aaagtgtgg  tagtttgga  atcagtttt  aaggaatct  ttggctctt  11100
tgttcctct  acataatat  ctaacatag  gcatctcaa  ggaaaagca  aacagttta  11160
ttggagttg  gaccacagt  ccttaaaat  tagagtagc  gagaaggca  ggcagcagt  11220
atccagagg  ggaagctca  ttgtcacat  tcaaccata  atggaaagc  gagagtgag  11280
aagaagtag  gctaagcta  gaactttca  agcttagtc  agtgacgta  ttcatccaa  11340
aagctttaa  cactttaat  aagattcca  aacctcaat  tgcactaca  attttggaa  11400
atgtgctca  gttcataaa  ctatctgaa  cattttaca  tcaaaccaa  aacaggaaa  11460
cattctgtt  cttaacttt  ttagcacac  ttatgctgt  aacattcta  tcctccaag  11520
tctaacaca  caccataga  cacctgtac  tcttcagta  actttaact  tgatcatga  11580
gaataatgt  cattggaaa  gaaacttat  aacagggaa  aaattgaag  cctaaataa  11640
gtaaactta  tattgagat  ggatatttg  gacactggt  gtcattcat  tatacatat  11700
cagcacaga  ttagactct  gagaacca  11728



<210> 3875
<211> 530
<212> PRT
<213> Rattus norvegicus
<308> AAA42314
<400> 3875

Met Pro Arg Lys Trp Ile Ser Ala Leu Phe Leu Leu Gln Ile Ser Tyr 
  1               5                  10                  15
Cys Phe Lys Ser Gly His Cys Gly Lys Val Leu Val Trp Pro Met Asp 
             20                  25                  30
Phe Ser His Trp Met Asn Ile Lys Ile Ile Leu Asp Glu Leu Val Gln 
         35                  40                  45
Arg Gly His Glu Val Thr Val Leu Lys Pro Ser Ala Tyr Phe Phe Leu 
     50                  55                  60
Asp Pro Lys Lys Ser Ser Asp Leu Lys Phe Glu Ile Phe Ser Thr Ser 
 65                  70                  75                  80
Ile Ser Lys Asp Glu Leu Gln Asn His Phe Ile Lys Leu Leu Asp Val 
                 85                  90                  95
Trp Thr Tyr Glu Leu Pro Arg Asp Thr Cys Leu Ser Tyr Ser Pro Ile 
             100                105                110
Leu Gln Asn Leu Val Tyr Glu Phe Ser Tyr Phe Tyr Leu Ser Ile Cys 
         115                120                125
Lys Asp Ala Val Ser Asn Lys Gln Leu Met Thr Lys Leu Gln Glu Ser 
     130                135                140
Lys Phe Asp Val Leu Phe Ala Asp Pro Val Ala Ser Cys Gly Asp Leu 
 145                150                155                160
Ile Ala Glu Leu Leu His Ile Pro Phe Leu Tyr Ser Leu Ser Phe Ser 
                 165                170                175
Pro Gly His Lys Leu Glu Lys Ser Ile Gly Lys Phe Ile Leu Pro Pro 
             180                185                190
Ser Tyr Val Pro Val Ile Leu Ser Gly Leu Ala Gly Lys Met Thr Phe 
         195                200                205
Ile Asp Arg Val Lys Asn Met Ile Cys Met Leu Tyr Phe Asp Phe Trp 
     210                215                220
Phe Glu Arg Leu Arg His Lys Glu Trp Asp Thr Phe Tyr Ser Glu Ile 
 225                230                235                240
Leu Gly Arg Pro Thr Thr Val Asp Glu Thr Met Ser Lys Val Glu Ile 
                 245                250                255
Trp Leu Ile Arg Ser Tyr Trp Asp Leu Lys Phe Pro His Pro Thr Leu 
             260                265                270
Pro Asn Val Asp Tyr Ile Gly Gly Leu His Cys Lys Pro Ala Lys Pro 
         275                280                285
Leu Pro Lys Asp Met Glu Glu Phe Val Gln Ser Ser Gly Glu His Gly 
     290                295                300
Val Val Val Phe Ser Leu Gly Ser Met Val Ser Asn Met Thr Glu Glu 
 305                310                315                320
Lys Ala Asn Ala Ile Ala Trp Ala Leu Ala Gln Ile Pro Gln Lys Val 
                 325                330                335
Leu Trp Lys Phe Asp Gly Lys Thr Pro Ala Thr Leu Gly Pro Asn Thr 
             340                345                350
Arg Val Tyr Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Lys 
         355                360                365
Thr Lys Ala Phe Val Thr His Gly Gly Ala Asn Gly Leu Tyr Glu Ala 
     370                375                380
Ile Tyr His Gly Ile Pro Met Ile Gly Ile Pro Leu Phe Gly Asp Gln 
 385                390                395                400
Pro Asp Asn Ile Ala His Met Val Ala Lys Gly Ala Ala Val Ser Leu 
                 405                410                415
Asn Ile Arg Thr Met Ser Lys Leu Asp Phe Leu Ser Ala Leu Glu Glu 
             420                425                430
Val Ile Asp Asn Pro Phe Tyr Lys Lys Asn Val Met Leu Leu Ser Thr 
         435                440                445
Ile His His Asp Gln Pro Met Lys Pro Leu Asp Arg Ala Val Phe Trp 
     450                455                460
Ile Glu Phe Ile Met Arg His Lys Gly Ala Lys His Leu Arg Pro Leu 
 465                470                475                480
Gly His Asn Leu Pro Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly 
                 485                490                495
Phe Leu Leu Thr Cys Phe Ala Val Ile Ala Ala Leu Thr Val Lys Cys 
             500                505                510
Leu Leu Phe Met Tyr Arg Phe Phe Val Lys Lys Glu Lys Lys Met Lys 
         515                520                525
Asn Glu 
     530



<210> 3876
<211> 2107
<212> DNA
<213> Homo sapiens
<308> NM_001077
<400> 3876

ggcacgagg  aagaaacaa  aactggaaa  gaagcattg  ataagacca  gatgtctct  60
aaatggatg  cagtctttc  gctgatgca  ctcagttgt  actttagct  tgggagttg  120
ggaaaggtg  tggtgtggc  cacagaata  agccattgg  taaatatga  gacaatcct  180
gaagagctt  ttcagaggg  tcatgaggt  attgtgttg  catcttcgg  ttctattct  240
gtcaatgcc  gtaaatcat  tgctattaa  ttagaagtt  atcctacat  tttaactaa  300
aatgatttg  aagattttt  tatgaaaat  ttcgataga  ggacatata  tatttcaaa  360
aatacattt  ggtcatatt  ttcacaact  caagaattg  gttgggaat  ttctgacta  420
aatataaag  tctgtgaag  tgcagtttt  aacaagaaa  ttatgagaa  actacaaga  480
tcaaaattt  atgtccttc  ggcagatgc  gttaatccc  gtggtgagc  gctggctga  540
ctacttaac  taccctttc  gtacagtct  cgcttctct  ttggctaca  agttgagaa  600
aatggtgga  gatttctgt  ccctccttc  tatgtacct  ttgttatgt  agaattaag  660
gatcaaatg  ttttcatgg  gaggataaa  aatatgata  atatgcttt  ttttgactt  720
tggtttcaa  catatgatc  gaagaagtg  gaccagttt  atagtgaag  tctaggaag  780
cccactaca  tatttgaga  aatggggaa  gctgaaatg  ggctcattc  aacctattg  840
gattttgaa  ttcctcgcc  attcttacc  aatgttgat  ttgttggag  acttcactg  900
aaaccagcc  aacccttgc  taaggaaat  gaagagttt  tgcagagct  tggagaaaa  960
ggtattgtg  tgttttctc  ggggtcgat  atcagtaac  tgtcagaag  aagtgccaa  1020
atgattgca  cagcccttg  ccagatccc  caaaaggtt  tatggagat  tgatggcaa  1080
aagccaaat  ctttaggtt  caatactcg  ctgtataag  ggttacccc  gaatgacct  1140
cttggtcat  ccaaaacca  agcttttat  actcatggt  gaaccaatg  catctatga  1200
gcgatctac  atgggatcc  tatggtggg  attcccttg  ttgcggatc  acatgataa  1260
attgctcac  tgaaagcca  gggagcagc  ctcagtgtg  acatcagga  catgtcaag  1320
agagatttg  tcaatgcat  gaagtcagt  attaatgac  ctatctata  agagaatat  1380
atgaaatta  caagaattc  tcatgatca  ccggtgaag  ccctggatc  agcagtctt  1440
tggattgag  ttgtcatgc  ccataaagg  gccaagcac  ttcgggtcg  agcccacaa  1500
ctcacctgg  tccagtacc  ctctttgga  gtgatagca  tcctgctgg  ctgcgtggc  1560
actatgata  ttatgatca  aaaatgttg  ctgttttgt  tccgaaagc  tgccaaaac  1620
ggaaagaag  agaaaaggg  ttagttata  caaaagcct  aagtggaat  accaaaaga  1680
gggactcct  ctttattcc  gcatggagg  ttttaaatg  aggatttcc  ttttcctgc  1740
acaaaacgt  ttttcacaa  ttaccctgt  aagtcaaaa  ttattttcc  ggaatttaa  1800
atgtacttt  gttggaatt  ttctatgtc  atgattttt  agctatgaa  aataataat  1860
taaaacctt  tgggcttat  ttgaaattt  ttattctaa  ccaaaagtt  ccccacaca  1920
aagttactg  gcttcctta  gtttcacac  ttgtatttg  acacaaaac  ttaacaact  1980
cactcatag  atcaacatt  ttttgcaaa  actcagaat  ttttggctt  attttgagc  2040
gaatttttg  ttttaattt  gccaatgaa  tcttcaata  ttaaaaaaa  aaaaaaaaa  2100
aaaaaaa  2107



<210> 3877
<211> 530
<212> PRT
<213> Homo sapiens
<308> O75795
<400> 3877

Met Ser Leu Lys Trp Met Ser Val Phe Leu Leu Met Gln Leu Ser Cys 
  1               5                  10                  15
Tyr Phe Ser Ser Gly Ser Cys Gly Lys Val Leu Val Trp Pro Thr Glu 
             20                  25                  30
Tyr Ser His Trp Ile Asn Met Lys Thr Ile Leu Glu Glu Leu Val Gln 
         35                  40                  45
Arg Gly His Glu Val Ile Val Leu Thr Ser Ser Ala Ser Ile Leu Val 
     50                  55                  60
Asn Ala Ser Lys Ser Ser Ala Ile Lys Leu Glu Val Tyr Pro Thr Ser 
 65                  70                  75                  80
Leu Thr Lys Asn Asp Leu Glu Asp Phe Phe Met Lys Met Phe Asp Arg 
                 85                  90                  95
Trp Thr Tyr Ser Ile Ser Lys Asn Thr Phe Trp Ser Tyr Phe Ser Gln 
             100                105                110
Leu Gln Glu Leu Cys Trp Glu Tyr Ser Asp Tyr Asn Ile Lys Leu Cys 
         115                120                125
Glu Asp Ala Val Leu Asn Lys Lys Leu Met Arg Lys Leu Gln Glu Ser 
     130                135                140
Lys Phe Asp Val Leu Leu Ala Asp Ala Val Asn Pro Cys Gly Glu Leu 
 145                150                155                160
Leu Ala Glu Leu Leu Asn Ile Pro Phe Leu Tyr Ser Leu Arg Phe Ser 
                 165                170                175
Val Gly Tyr Thr Val Glu Lys Asn Gly Gly Gly Phe Leu Phe Pro Pro 
             180                185                190
Ser Tyr Val Pro Val Val Met Ser Glu Leu Ser Asp Gln Met Ile Phe 
         195                200                205
Met Glu Arg Ile Lys Asn Met Ile Tyr Met Leu Tyr Phe Asp Phe Trp 
     210                215                220
Phe Gln Ala Tyr Asp Leu Lys Lys Trp Asp Gln Phe Tyr Ser Glu Val 
 225                230                235                240
Leu Gly Arg Pro Thr Thr Leu Phe Glu Thr Met Gly Lys Ala Glu Met 
                 245                250                255
Trp Leu Ile Arg Thr Tyr Trp Asp Phe Glu Phe Pro Arg Pro Phe Leu 
             260                265                270
Pro Asn Val Asp Phe Val Gly Gly Leu His Cys Lys Pro Ala Lys Pro 
         275                280                285
Leu Pro Lys Glu Met Glu Glu Phe Val Gln Ser Ser Gly Glu Asn Gly 
     290                295                300
Ile Val Val Phe Ser Leu Gly Ser Met Ile Ser Asn Met Ser Glu Glu 
 305                310                315                320
Ser Ala Asn Met Ile Ala Ser Ala Leu Ala Gln Ile Pro Gln Lys Val 
                 325                330                335
Leu Trp Arg Phe Asp Gly Lys Lys Pro Asn Thr Leu Gly Ser Asn Thr 
             340                345                350
Arg Leu Tyr Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Lys 
         355                360                365
Thr Lys Ala Phe Ile Thr His Gly Gly Thr Asn Gly Ile Tyr Glu Ala 
     370                375                380
Ile Tyr His Gly Ile Pro Met Val Gly Ile Pro Leu Phe Ala Asp Gln 
 385                390                395                400
His Asp Asn Ile Ala His Met Lys Ala Lys Gly Ala Ala Leu Ser Val 
                 405                410                415
Asp Ile Arg Thr Met Ser Ser Arg Asp Leu Leu Asn Ala Leu Lys Ser 
             420                425                430
Val Ile Asn Asp Pro Ile Tyr Lys Glu Asn Ile Met Lys Leu Ser Arg 
         435                440                445
Ile His His Asp Gln Pro Val Lys Pro Leu Asp Arg Ala Val Phe Trp 
     450                455                460
Ile Glu Phe Val Met Arg His Lys Gly Ala Lys His Leu Arg Val Ala 
 465                470                475                480
Ala His Asn Leu Thr Trp Ile Gln Tyr His Ser Leu Asp Val Ile Ala 
                 485                490                495
Phe Leu Leu Ala Cys Val Ala Thr Met Ile Phe Met Ile Thr Lys Cys 
             500                505                510
Cys Leu Phe Cys Phe Arg Lys Leu Ala Lys Thr Gly Lys Lys Lys Lys 
         515                520                525
Arg Asp 
     530



<210> 3878
<211> 936
<212> DNA
<213> Rattus norvegicus
<308> M74494
<400> 3878

accgtcacg  tatgtctga  gctcactgc  aagcgcatg  cgaggaaga  ctgcctggt  60
aagaacctg  aagctgtgg  gaccttggg  tccacatcc  ccatctgct  cgacaagac  120
ggaactctg  ctcagaacc  gatgacagt  gctcacatg  ggtttgaca  tcaaatcca  180
gaagctgac  ccacagaga  tcagagtgg  gtctccttt  acaagacgt  agccacctg  240
ttcgctctg  ccagaattg  tggtctctg  aacagggca  tgtttcagg  taaccaaga  300
aacctgcct  tccttaagc  tgcagtagc  ggagatgct  ccgagtcgg  gctcttaaa  360
tgcatcgag  tctgctgtg  ctccgtgat  gagatgagg  agaagtaca  caagatagt  420
gagattcct  tcaactcca  caacaagta  cagctctcc  ttcacaaga  cccaaacgc  480
tcggagcct  agcacctgc  agtgatgaa  ggcgcccca  aaaggatcc  ggaccgatg  540
agttctatc  tcctccacg  caaggagca  cccctggac  aagagctga  ggacgcctt  600
cagaatgcc  acctagagc  ggggggcct  ggagagcgt  tgctaggta  gcaggtgac  660
gccatggct  ctgagcaca  ctgtgtcaa  cacagcgat  tccgtgttc  cggggtgtt  720
ctcttaacg  aggggagcc  cgctgctga  tacattgtt  aaagcagag  tgtggagaa  780
taatggtta  attggcaaa  agtgttgtt  cttggctga  ctgtggctt  acgatatca  840
ttctatatg  caggaggtg  gggtgggca  tttattgtc  aacctcatt  ttatggcca  900
ggtctgtaa  cttaattaa  atctgtttg  ttctgg  936



<210> 3879
<211> 1023
<212> PRT
<213> Rattus norvegicus
<308> P06685
<400> 3879

Met Gly Lys Gly Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
  1               5                  10                  15
Glu His Gly Asp Lys Lys Ser Lys Lys Ala Lys Lys Glu Arg Asp Met 
             20                  25                  30
Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
         35                  40                  45
Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
     50                  55                  60
Pro Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
 65                  70                  75                  80
Thr Pro Pro Pro Thr Thr Pro Glu Trp Val Lys Phe Cys Arg Gln Leu 
                 85                  90                  95
Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
             100                105                110
Leu Ala Tyr Gly Ile Arg Ser Ala Thr Glu Glu Glu Pro Pro Asn Asp 
         115                120                125
Asp Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
     130                135                140
Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
 145                150                155                160
Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                 165                170                175
Lys Met Ser Ile Asn Ala Glu Asp Val Val Val Gly Asp Leu Val Glu 
             180                185                190
Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
         195                200                205
Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
     210                215                220
Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
 225                230                235                240
Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                 245                250                255
Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
             260                265                270
Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Glu Glu Ile 
         275                280                285
Glu His Phe Ile His Leu Ile Thr Gly Val Ala Val Phe Leu Gly Val 
     290                295                300
Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
 305                310                315                320
Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                 325                330                335
Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
             340                345                350
Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
         355                360                365
Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
     370                375                380
Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
 385                390                395                400
Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                 405                410                415
Thr Trp Phe Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
             420                425                430
Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
         435                440                445
Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Val Cys Cys 
     450                455                460
Gly Ser Val Met Glu Met Arg Glu Lys Tyr Thr Lys Ile Val Glu Ile 
 465                470                475                480
Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                 485                490                495
Asn Ala Ser Glu Pro Lys His Leu Leu Val Met Lys Gly Ala Pro Glu 
             500                505                510
Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
         515                520                525
Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
     530                535                540
Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Leu Leu 
 545                550                555                560
Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Glu Val 
                 565                570                575
Asn Phe Pro Val Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
             580                585                590
Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
         595                600                605
Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
     610                615                620
Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
 625                630                635                640
Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Asn Gln Val Asn 
                 645                650                655
Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
             660                665                670
Met Thr Ser Glu Glu Leu Asp Asp Ile Leu Arg Tyr His Thr Glu Ile 
         675                680                685
Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
     690                695                700
Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
 705                710                715                720
Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                 725                730                735
Val Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
             740                745                750
Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
         755                760                765
Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
     770                775                780
Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu 
 785                790                795                800
Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                 805                810                815
Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
             820                825                830
Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
         835                840                845
Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
     850                855                860
Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
 865                870                875                880
Phe His Leu Leu Gly Ile Arg Glu Thr Trp Asp Asp Arg Trp Ile Asn 
                 885                890                895
Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
             900                905                910
Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
         915                920                925
Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
     930                935                940
Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
 945                950                955                960
Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Ala 
                 965                970                975
Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
             980                985                990
Pro Tyr Ser Leu Leu Ile Phe Val Tyr Asp Glu Val Arg Lys Leu Ile 
         995                1000                1005
Ile Arg Arg Arg Pro Gly Gly Trp Val Glu Lys Glu Thr Tyr Tyr 
     1010                1015                1020



<210> 3880
<211> 4108
<212> DNA
<213> Homo sapiens
<308> D00099
<400> 3880

gaattctta  gtctaaggg  cttgctcct  atcttcctg  agatctcta  catttaatt  60
agaaagcag  tgctgttcg  aagcatctt  agaggaacg  acacgtggc  acagcggta  120
gagcccggg  ggcggcagc  acagcggcg  cggcatcgg  ccgagccgc  gcccgctcc  180
accctcccg  cccgcggca  ccctagctc  ctccacttg  ctcccctgg  cccgctcgc  240
cggccggga  ctgctctgt  cttttctct  tgattctcc  gcgacagga  ccggcgccg  300
gcactgagc  ccgccacca  ggggaaggg  gttggacgt  ataagtatg  gcctgcagc  360
gtttcagaa  aaggtgata  aaagggcaa  aagggcaaa  aagacaggg  catggatga  420
ctgaagaaa  aagtttcta  ggatgatca  aaacttagc  ttgatgaac  tcatcgtaa  480
tatggaaca  acttgagcc  gggattaac  tctgctcgt  cagctgaga  cctggcgcg  540
gatggtccc  acgccctca  tccccctcc  actactcct  aatggatca  gttttgtcg  600
cagctcttt  gggggttct  aatgttact  tggattgga  cgattcttt  tttcttggc  660
tatagcatc  aagctgcta  agaagagga  cctcaaaac  ataatctgt  cctgggtgt  720
gtgctatca  ccgttgtaa  cataactgg  tgcttctcc  actatcaag  agctaaaag  780
tcaaagatc  tggaatcct  caaaaacat  gtccctcag  aagcccttg  gattcgaaa  840
ggtgagaaa  tgagcataa  tgcggagga  gttgtggtt  gggatctgg  ggaagtaaa  900
ggaggagac  gaattcctg  tgacctcag  atcatatct  caaatggct  caaggtgga  960
aactcctcg  tcactggtg  atcagaacc  cagactagg  ctccagatt  cacaaatga  1020
aaccccctg  agacgagga  cattgcctt  ttttcaaca  attgtgttg  aggcaccgc  1080
cgtggtatt  ttgtctaca  tggggatcg  actgtgatg  gaagaattg  cacacttgc  1140
tctgggctg  aaggaggcc  gacccccat  gctgcagaa  ttgaacatt  tatccacat  1200
atcacgggt  tggctgtgt  cctgggtgt  tctttcttc  tcctttctc  catccttga  1260
tacacctgg  ttgaggctg  catcttcct  atcggtatc  tcgtagcca  tgtgccgga  1320
ggtttgctg  ccactgtca  ggtctgtct  acacttact  ccaaacgca  ggcaaggaa  1380
aactgctta  tgaagaact  agaagctgt  gagaccttg  ggtccacgt  caccatctg  1440
tctgataaa  ctggaactc  gactcagaa  cggatgaca  tggcccaca  gtggtttga  1500
aatcaaatc  atgaagctg  tacgacaga  aatcagagt  gtgtctctt  tgacaagac  1560
tcagctacc  ggcttgctc  gtccagaat  gcaggtctt  gtaacaggg  agtgtttca  1620
gctaaccag  aaaacctac  tattcttaa  cgggcagtt  caggagatg  ctctgagtc  1680
gcactctta  agtgcatag  gctgtgctg  ggttccgtg  aggagatga  agaaagata  1740
gccaaaatc  tcgagatac  cttcaactc  accaacaag  accagttgt  tattcataa  1800
aaccccaac  catcggagc  ccaacacct  ttggtgatg  agggcgccc  agaaaggat  1860
ctagaccgt  gcagctcta  cctcctcca  ggcaaggag  agcccctgg  tgaggagct  1920
aaagacgcc  ttcagaacg  ctatttgga  ctggggggc  tcggagaac  agtcctagg  1980
ttctgccac  tctttctgc  agatgaaca  tttcctgaa  ggttccagt  tgacactga  2040
gatgtgaat  tccctatcg  taatctgtg  tttgttggg  tcatctcca  gattgaccc  2100
ccacgggcg  ccgttcctg  tgccgtggg  aaatgtcga  gtgctggaa  taaggtcat  2160
atggtcaca  gagaccatc  aatcacagc  aaagctatt  ccaaaggtg  gggcatcat  2220
tcagaaggc  atgagaccg  ggaagacat  gctgcccgc  tcaacatcc  agtcagcca  2280
gtgaacccc  gggatgcca  ggcctgcgt  gtacacggc  gtgatctaa  ggacatgac  2340
tccgagcag  tggatgaca  tttgaagta  cacactgag  tagtgtttg  caggacctc  2400
cctcagcag  agctcatca  tgtggaagg  tgccaaaga  agggtgcta  cgtggctgt  2460
actggtgac  gtgtgaatg  ctctccagc  ttgaagaaa  cagacattg  ggttgctat  2520
gggattgct  gctcagatg  gtccaagca  gctgctgac  tgattcttc  ggatgacaa  2580
tttgcctca  ttgtgactg  agtagagga  ggtcgtctg  tctttgata  cttgaagaa  2640
tccattgct  ataccttaa  cagtaacat  cccgagatc  ccccgttcc  gatatttat  2700
attgcaaac  ttccactac  actggggac  gtcaccatc  tctgcattg  cttgggcac  2760
gacatggtt  ctgccatct  cctggctta  gagcaggct  agagtgaca  catgaagag  2820
cagcccaga  atcccaaaa  agacaaact  gtgaatgag  ggctgatca  catggccta  2880
gggcagatt  gaatgatcc  ggccctggg  ggcttcttt  cttactttg  gattctggc  2940
gagaacggc  tcctcccaa  tcacctgtt  ggcctccga  tggactggg  tgaccgctg  3000
atcaacgat  tggaagaca  ctacgggca  cagtggacc  atgagcaga  gaaaatcgt  3060
gagttcacc  gccacacag  cttcttcgt  agtatcgtg  tggtgcagt  ggccgactt  3120
gtcatctgt  agaccagga  gaattcggt  ttccagcag  ggatgaaga  caagatctt  3180
atatttggc  tctttgaag  gacagccct  gctgctttc  tttcctact  ccctggaat  3240
ggtgttgct  ttaggatgt  tcccctcaa  cctacctgg  ggttctgtg  cttccccta  3300
tctcttctc  tcttcgtat  tgacgaagt  agaaaactc  tcatcaggc  acgccctgg  3360
ggctgggtg  agaaggaaa  ctactatta  ccccccgtc  tgcacgccg  ggagcatca  3420
gccacacac  ctgcatccg  cacccaccc  ctctttgtg  acttcagtc  tggagtttg  3480
aactctacc  tggtaggaa  gcaccgcag  atgtgggga  gcaagacgt  ctggaatga  3540
gcatgtagc  ctatggggg  aggggggag  gctgcctga  aaccatcca  ctgtggaaa  3600
gacagcggg  aaggttttt  tgtgccttt  tgtttttgt  aaaaaggaa  acccggaaa  3660
actgaaaga  tacatttta  atctggatt  ttacaaata  agatggcag  aactgactt  3720
attttaagg  ttccagcat  ccagagcca  aaacaaata  tgccatctg  cccagtaga  3780
gatagatat  tctttgagc  actgcacaa  ggtgagaac  gtagtgatg  aatagatgc  3840
ctatggccc  gaagaacag  caaaggtgc  caggttcga  gacaccaga  tcggatcat  3900
ttatcacaa  ttccagctg  tatcatggt  ttctcatag  ttacagcca  gtctgatat  3960
tcagcagca  gtcctctta  ggtagctaa  aacctccca  catctgttg  ccatatttt  4020
acaagacag  catcagaac  agtaaatat  cgtctgcca  ttcgatcaa  agttacaca  4080
tacacagat  acaagtgtc  aagaattc  4108



<210> 3881
<211> 1023
<212> PRT
<213> Homo sapiens
<308> P05023
<400> 3881

Met Gly Lys Gly Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
  1               5                  10                  15
Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
             20                  25                  30
Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
         35                  40                  45
Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
     50                  55                  60
Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
 65                  70                  75                  80
Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                 85                  90                  95
Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
             100                105                110
Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp 
         115                120                125
Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
     130                135                140
Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
 145                150                155                160
Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                 165                170                175
Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu 
             180                185                190
Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
         195                200                205
Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
     210                215                220
Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
 225                230                235                240
Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                 245                250                255
Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
             260                265                270
Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile 
         275                280                285
Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val 
     290                295                300
Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
 305                310                315                320
Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                 325                330                335
Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
             340                345                350
Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
         355                360                365
Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
     370                375                380
Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
 385                390                395                400
Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                 405                410                415
Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
             420                425                430
Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
         435                440                445
Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys 
     450                455                460
Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile 
 465                470                475                480
Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                 485                490                495
Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu 
             500                505                510
Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
         515                520                525
Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
     530                535                540
Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu 
 545                550                555                560
Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val 
                 565                570                575
Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
             580                585                590
Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
         595                600                605
Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
     610                615                620
Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
 625                630                635                640
Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn 
                 645                650                655
Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
             660                665                670
Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile 
         675                680                685
Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
     690                695                700
Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
 705                710                715                720
Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                 725                730                735
Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
             740                745                750
Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
         755                760                765
Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
     770                775                780
Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu 
 785                790                795                800
Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                 805                810                815
Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
             820                825                830
Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
         835                840                845
Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
     850                855                860
Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
 865                870                875                880
Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn 
                 885                890                895
Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
             900                905                910
Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
         915                920                925
Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
     930                935                940
Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
 945                950                955                960
Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val 
                 965                970                975
Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
             980                985                990
Pro Tyr Ser Leu Leu Ile Phe Val Tyr Asp Glu Val Arg Lys Leu Ile 
         995                1000                1005
Ile Arg Arg Arg Pro Gly Gly Trp Val Glu Lys Glu Thr Tyr Tyr 
     1010                1015                1020



<210> 3882
<211> 936
<212> DNA
<213> Rattus norvegicus
<308> M74494
<400> 3882

accgtcacg  tatgtctga  gctcactgc  aagcgcatg  cgaggaaga  ctgcctggt  60
aagaacctg  aagctgtgg  gaccttggg  tccacatcc  ccatctgct  cgacaagac  120
ggaactctg  ctcagaacc  gatgacagt  gctcacatg  ggtttgaca  tcaaatcca  180
gaagctgac  ccacagaga  tcagagtgg  gtctccttt  acaagacgt  agccacctg  240
ttcgctctg  ccagaattg  tggtctctg  aacagggca  tgtttcagg  taaccaaga  300
aacctgcct  tccttaagc  tgcagtagc  ggagatgct  ccgagtcgg  gctcttaaa  360
tgcatcgag  tctgctgtg  ctccgtgat  gagatgagg  agaagtaca  caagatagt  420
gagattcct  tcaactcca  caacaagta  cagctctcc  ttcacaaga  cccaaacgc  480
tcggagcct  agcacctgc  agtgatgaa  ggcgcccca  aaaggatcc  ggaccgatg  540
agttctatc  tcctccacg  caaggagca  cccctggac  aagagctga  ggacgcctt  600
cagaatgcc  acctagagc  ggggggcct  ggagagcgt  tgctaggta  gcaggtgac  660
gccatggct  ctgagcaca  ctgtgtcaa  cacagcgat  tccgtgttc  cggggtgtt  720
ctcttaacg  aggggagcc  cgctgctga  tacattgtt  aaagcagag  tgtggagaa  780
taatggtta  attggcaaa  agtgttgtt  cttggctga  ctgtggctt  acgatatca  840
ttctatatg  caggaggtg  gggtgggca  tttattgtc  aacctcatt  ttatggcca  900
ggtctgtaa  cttaattaa  atctgtttg  ttctgg  936



<210> 3883
<211> 1023
<212> PRT
<213> Rattus norvegicus
<308> P06685
<400> 3883

Met Gly Lys Gly Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
  1               5                  10                  15
Glu His Gly Asp Lys Lys Ser Lys Lys Ala Lys Lys Glu Arg Asp Met 
             20                  25                  30
Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
         35                  40                  45
Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
     50                  55                  60
Pro Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
 65                  70                  75                  80
Thr Pro Pro Pro Thr Thr Pro Glu Trp Val Lys Phe Cys Arg Gln Leu 
                 85                  90                  95
Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
             100                105                110
Leu Ala Tyr Gly Ile Arg Ser Ala Thr Glu Glu Glu Pro Pro Asn Asp 
         115                120                125
Asp Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
     130                135                140
Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
 145                150                155                160
Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                 165                170                175
Lys Met Ser Ile Asn Ala Glu Asp Val Val Val Gly Asp Leu Val Glu 
             180                185                190
Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
         195                200                205
Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
     210                215                220
Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
 225                230                235                240
Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                 245                250                255
Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
             260                265                270
Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Glu Glu Ile 
         275                280                285
Glu His Phe Ile His Leu Ile Thr Gly Val Ala Val Phe Leu Gly Val 
     290                295                300
Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
 305                310                315                320
Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                 325                330                335
Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
             340                345                350
Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
         355                360                365
Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
     370                375                380
Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
 385                390                395                400
Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                 405                410                415
Thr Trp Phe Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
             420                425                430
Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
         435                440                445
Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Val Cys Cys 
     450                455                460
Gly Ser Val Met Glu Met Arg Glu Lys Tyr Thr Lys Ile Val Glu Ile 
 465                470                475                480
Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                 485                490                495
Asn Ala Ser Glu Pro Lys His Leu Leu Val Met Lys Gly Ala Pro Glu 
             500                505                510
Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
         515                520                525
Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
     530                535                540
Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Leu Leu 
 545                550                555                560
Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Glu Val 
                 565                570                575
Asn Phe Pro Val Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
             580                585                590
Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
         595                600                605
Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
     610                615                620
Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
 625                630                635                640
Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Asn Gln Val Asn 
                 645                650                655
Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
             660                665                670
Met Thr Ser Glu Glu Leu Asp Asp Ile Leu Arg Tyr His Thr Glu Ile 
         675                680                685
Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
     690                695                700
Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
 705                710                715                720
Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                 725                730                735
Val Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
             740                745                750
Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
         755                760                765
Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
     770                775                780
Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu 
 785                790                795                800
Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                 805                810                815
Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
             820                825                830
Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
         835                840                845
Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
     850                855                860
Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
 865                870                875                880
Phe His Leu Leu Gly Ile Arg Glu Thr Trp Asp Asp Arg Trp Ile Asn 
                 885                890                895
Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
             900                905                910
Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
         915                920                925
Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
     930                935                940
Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
 945                950                955                960
Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Ala 
                 965                970                975
Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
             980                985                990
Pro Tyr Ser Leu Leu Ile Phe Val Tyr Asp Glu Val Arg Lys Leu Ile 
         995                1000                1005
Ile Arg Arg Arg Pro Gly Gly Trp Val Glu Lys Glu Thr Tyr Tyr 
     1010                1015                1020



<210> 3884
<211> 4108
<212> DNA
<213> Homo sapiens
<308> D00099
<400> 3884

gaattctta  gtctaaggg  cttgctcct  atcttcctg  agatctcta  catttaatt  60
agaaagcag  tgctgttcg  aagcatctt  agaggaacg  acacgtggc  acagcggta  120
gagcccggg  ggcggcagc  acagcggcg  cggcatcgg  ccgagccgc  gcccgctcc  180
accctcccg  cccgcggca  ccctagctc  ctccacttg  ctcccctgg  cccgctcgc  240
cggccggga  ctgctctgt  cttttctct  tgattctcc  gcgacagga  ccggcgccg  300
gcactgagc  ccgccacca  ggggaaggg  gttggacgt  ataagtatg  gcctgcagc  360
gtttcagaa  aaggtgata  aaagggcaa  aagggcaaa  aagacaggg  catggatga  420
ctgaagaaa  aagtttcta  ggatgatca  aaacttagc  ttgatgaac  tcatcgtaa  480
tatggaaca  acttgagcc  gggattaac  tctgctcgt  cagctgaga  cctggcgcg  540
gatggtccc  acgccctca  tccccctcc  actactcct  aatggatca  gttttgtcg  600
cagctcttt  gggggttct  aatgttact  tggattgga  cgattcttt  tttcttggc  660
tatagcatc  aagctgcta  agaagagga  cctcaaaac  ataatctgt  cctgggtgt  720
gtgctatca  ccgttgtaa  cataactgg  tgcttctcc  actatcaag  agctaaaag  780
tcaaagatc  tggaatcct  caaaaacat  gtccctcag  aagcccttg  gattcgaaa  840
ggtgagaaa  tgagcataa  tgcggagga  gttgtggtt  gggatctgg  ggaagtaaa  900
ggaggagac  gaattcctg  tgacctcag  atcatatct  caaatggct  caaggtgga  960
aactcctcg  tcactggtg  atcagaacc  cagactagg  ctccagatt  cacaaatga  1020
aaccccctg  agacgagga  cattgcctt  ttttcaaca  attgtgttg  aggcaccgc  1080
cgtggtatt  ttgtctaca  tggggatcg  actgtgatg  gaagaattg  cacacttgc  1140
tctgggctg  aaggaggcc  gacccccat  gctgcagaa  ttgaacatt  tatccacat  1200
atcacgggt  tggctgtgt  cctgggtgt  tctttcttc  tcctttctc  catccttga  1260
tacacctgg  ttgaggctg  catcttcct  atcggtatc  tcgtagcca  tgtgccgga  1320
ggtttgctg  ccactgtca  ggtctgtct  acacttact  ccaaacgca  ggcaaggaa  1380
aactgctta  tgaagaact  agaagctgt  gagaccttg  ggtccacgt  caccatctg  1440
tctgataaa  ctggaactc  gactcagaa  cggatgaca  tggcccaca  gtggtttga  1500
aatcaaatc  atgaagctg  tacgacaga  aatcagagt  gtgtctctt  tgacaagac  1560
tcagctacc  ggcttgctc  gtccagaat  gcaggtctt  gtaacaggg  agtgtttca  1620
gctaaccag  aaaacctac  tattcttaa  cgggcagtt  caggagatg  ctctgagtc  1680
gcactctta  agtgcatag  gctgtgctg  ggttccgtg  aggagatga  agaaagata  1740
gccaaaatc  tcgagatac  cttcaactc  accaacaag  accagttgt  tattcataa  1800
aaccccaac  catcggagc  ccaacacct  ttggtgatg  agggcgccc  agaaaggat  1860
ctagaccgt  gcagctcta  cctcctcca  ggcaaggag  agcccctgg  tgaggagct  1920
aaagacgcc  ttcagaacg  ctatttgga  ctggggggc  tcggagaac  agtcctagg  1980
ttctgccac  tctttctgc  agatgaaca  tttcctgaa  ggttccagt  tgacactga  2040
gatgtgaat  tccctatcg  taatctgtg  tttgttggg  tcatctcca  gattgaccc  2100
ccacgggcg  ccgttcctg  tgccgtggg  aaatgtcga  gtgctggaa  taaggtcat  2160
atggtcaca  gagaccatc  aatcacagc  aaagctatt  ccaaaggtg  gggcatcat  2220
tcagaaggc  atgagaccg  ggaagacat  gctgcccgc  tcaacatcc  agtcagcca  2280
gtgaacccc  gggatgcca  ggcctgcgt  gtacacggc  gtgatctaa  ggacatgac  2340
tccgagcag  tggatgaca  tttgaagta  cacactgag  tagtgtttg  caggacctc  2400
cctcagcag  agctcatca  tgtggaagg  tgccaaaga  agggtgcta  cgtggctgt  2460
actggtgac  gtgtgaatg  ctctccagc  ttgaagaaa  cagacattg  ggttgctat  2520
gggattgct  gctcagatg  gtccaagca  gctgctgac  tgattcttc  ggatgacaa  2580
tttgcctca  ttgtgactg  agtagagga  ggtcgtctg  tctttgata  cttgaagaa  2640
tccattgct  ataccttaa  cagtaacat  cccgagatc  ccccgttcc  gatatttat  2700
attgcaaac  ttccactac  actggggac  gtcaccatc  tctgcattg  cttgggcac  2760
gacatggtt  ctgccatct  cctggctta  gagcaggct  agagtgaca  catgaagag  2820
cagcccaga  atcccaaaa  agacaaact  gtgaatgag  ggctgatca  catggccta  2880
gggcagatt  gaatgatcc  ggccctggg  ggcttcttt  cttactttg  gattctggc  2940
gagaacggc  tcctcccaa  tcacctgtt  ggcctccga  tggactggg  tgaccgctg  3000
atcaacgat  tggaagaca  ctacgggca  cagtggacc  atgagcaga  gaaaatcgt  3060
gagttcacc  gccacacag  cttcttcgt  agtatcgtg  tggtgcagt  ggccgactt  3120
gtcatctgt  agaccagga  gaattcggt  ttccagcag  ggatgaaga  caagatctt  3180
atatttggc  tctttgaag  gacagccct  gctgctttc  tttcctact  ccctggaat  3240
ggtgttgct  ttaggatgt  tcccctcaa  cctacctgg  ggttctgtg  cttccccta  3300
tctcttctc  tcttcgtat  tgacgaagt  agaaaactc  tcatcaggc  acgccctgg  3360
ggctgggtg  agaaggaaa  ctactatta  ccccccgtc  tgcacgccg  ggagcatca  3420
gccacacac  ctgcatccg  cacccaccc  ctctttgtg  acttcagtc  tggagtttg  3480
aactctacc  tggtaggaa  gcaccgcag  atgtgggga  gcaagacgt  ctggaatga  3540
gcatgtagc  ctatggggg  aggggggag  gctgcctga  aaccatcca  ctgtggaaa  3600
gacagcggg  aaggttttt  tgtgccttt  tgtttttgt  aaaaaggaa  acccggaaa  3660
actgaaaga  tacatttta  atctggatt  ttacaaata  agatggcag  aactgactt  3720
attttaagg  ttccagcat  ccagagcca  aaacaaata  tgccatctg  cccagtaga  3780
gatagatat  tctttgagc  actgcacaa  ggtgagaac  gtagtgatg  aatagatgc  3840
ctatggccc  gaagaacag  caaaggtgc  caggttcga  gacaccaga  tcggatcat  3900
ttatcacaa  ttccagctg  tatcatggt  ttctcatag  ttacagcca  gtctgatat  3960
tcagcagca  gtcctctta  ggtagctaa  aacctccca  catctgttg  ccatatttt  4020
acaagacag  catcagaac  agtaaatat  cgtctgcca  ttcgatcaa  agttacaca  4080
tacacagat  acaagtgtc  aagaattc  4108



<210> 3885
<211> 1023
<212> PRT
<213> Homo sapiens
<308> P05023
<400> 3885

Met Gly Lys Gly Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
  1               5                  10                  15
Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
             20                  25                  30
Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
         35                  40                  45
Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
     50                  55                  60
Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
 65                  70                  75                  80
Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                 85                  90                  95
Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
             100                105                110
Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp 
         115                120                125
Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
     130                135                140
Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
 145                150                155                160
Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                 165                170                175
Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu 
             180                185                190
Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
         195                200                205
Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
     210                215                220
Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
 225                230                235                240
Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                 245                250                255
Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
             260                265                270
Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile 
         275                280                285
Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val 
     290                295                300
Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
 305                310                315                320
Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                 325                330                335
Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
             340                345                350
Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
         355                360                365
Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
     370                375                380
Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
 385                390                395                400
Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                 405                410                415
Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
             420                425                430
Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
         435                440                445
Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys 
     450                455                460
Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile 
 465                470                475                480
Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                 485                490                495
Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu 
             500                505                510
Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
         515                520                525
Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
     530                535                540
Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu 
 545                550                555                560
Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val 
                 565                570                575
Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
             580                585                590
Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
         595                600                605
Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
     610                615                620
Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
 625                630                635                640
Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn 
                 645                650                655
Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
             660                665                670
Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile 
         675                680                685
Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
     690                695                700
Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
 705                710                715                720
Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                 725                730                735
Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
             740                745                750
Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
         755                760                765
Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
     770                775                780
Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu 
 785                790                795                800
Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                 805                810                815
Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
             820                825                830
Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
         835                840                845
Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
     850                855                860
Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
 865                870                875                880
Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn 
                 885                890                895
Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
             900                905                910
Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
         915                920                925
Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
     930                935                940
Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
 945                950                955                960
Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val 
                 965                970                975
Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
             980                985                990
Pro Tyr Ser Leu Leu Ile Phe Val Tyr Asp Glu Val Arg Lys Leu Ile 
         995                1000                1005
Ile Arg Arg Arg Pro Gly Gly Trp Val Glu Lys Glu Thr Tyr Tyr 
     1010                1015                1020



<210> 3886
<211> 895
<212> DNA
<213> Rattus norvegicus
<308> M75153
<400> 3886

atgggcacc  gcgacgacg  gtacgacta  ctctttaaa  ttgtcctta  tggagattc  60
ggtgttggg  agagtaacc  cctgtctcg  tttactcgg  atgagttta  tctggaaag  120
aagagtacc  ttggagtag  atttgcaac  agaagcatc  aggttgatg  gaaaacaat  180
aaggcacag  tatgggaca  agcagggca  gagcggtac  gggctataa  gtctgcata  240
tatcgtgga  cagtaggtg  cttattggt  tatgacatt  ctaagcatc  cacatatga  300
aatgtagaa  gatggctga  agaactgag  gatcatgct  atagtaaca  tgttatcat  360
cttgtgggc  ataagagtg  tttacgtca  ctcagggca  ttcctacag  tgaagcaag  420
gcatttgca  agaagaatg  tttgtcgtt  attgagaca  ctgctctag  ttctacaaa  480
gttgaagct  cttttcaga  aattctaac  gagatatac  gcattgttt  tcagaagca  540
atgtcagac  gacgtgaaa  tgacatgtc  ccaagcaac  atgtggttc  tattcatgt  600
ccacccacc  ctgagaaca  gccaaaggt  cagtgctgt  agaacatct  aggcgcctc  660
ctcccctag  cggctgtgt  tagtccatt  cccaggtct  agatttaaa  atatttgta  720
ttcttgtgg  cactttctg  gttttatta  ttccttaca  ttaagaatc  tcccatgtc  780
taagtcttt  atttggctt  ataaaatcc  caactttgt  ctgaatgac  cgagttctt  840
ttcatgcta  ggcttctct  gccttagtt  aataaactg  atgtttgaa  tcctc  895



<210> 3887
<211> 216
<212> PRT
<213> Rattus norvegicus
<308> P24410
<400> 3887

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
  1               5                  10                  15
Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
             20                  25                  30
Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
         35                  40                  45
Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
     50                  55                  60
Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
 65                  70                  75                  80
Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                 85                  90                  95
Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
             100                105                110
Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
         115                120                125
Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
     130                135                140
Lys Asn Gly Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
 145                150                155                160
Val Glu Ala Ala Phe Gln Thr Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                 165                170                175
Ser Gln Lys Gln Met Ser Asp Arg Arg Glu Asn Asp Met Ser Pro Ser 
             180                185                190
Asn Asn Val Val Pro Ile His Val Pro Pro Thr Thr Glu Asn Lys Pro 
         195                200                205
Lys Val Gln Cys Cys Gln Asn Ile 
     210                215



<210> 3888
<211> 651
<212> DNA
<213> Homo sapiens
<308> X53143
<400> 3888

atgggcacc  gcgacgacg  gtacgacta  ctctttaaa  ttgtcctta  tggagattc  60
ggtgttgga  agagtaatc  cctgtctcg  tttactcga  atgagttta  tctggaaag  120
aagagcacc  ttggagtag  gtttgcaac  agaagcatc  aggttgatg  aaaaacaat  180
aaggcacag  tatgggaca  agcagggca  gagcgatat  gagctataa  atcagcata  240
tatcgtgga  ctgtaggtg  cttattggt  tatgacatt  ctaaacatc  cacatatga  300
aatgtagag  gatggctga  agaactgag  gatcatgct  atagtaaca  tgttatcat  360
cttgtgggc  ataagagtg  tctacgtca  ctcagggca  ttcctacag  tgaagcaag  420
gcttttgca  aaaagaatg  tttgtcatt  attgaaact  cggccctag  ctctacaaa  480
gtagaagct  cttttcaga  aattttaac  gagatttac  gcattgttt  tcagaagca  540
atgtcagac  gacgcgaaa  tgacatgtc  ccaagcaac  atgtggttc  tattcatgt  600
ccaccaacc  ctgaaaaca  gccaaaggt  cagtgctgt  agaacatct  a  651



<210> 3889
<211> 216
<212> PRT
<213> Homo sapiens
<308> P24410
<400> 3889

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
  1               5                  10                  15
Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
             20                  25                  30
Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
         35                  40                  45
Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
     50                  55                  60
Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
 65                  70                  75                  80
Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                 85                  90                  95
Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
             100                105                110
Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
         115                120                125
Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
     130                135                140
Lys Asn Gly Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
 145                150                155                160
Val Glu Ala Ala Phe Gln Thr Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                 165                170                175
Ser Gln Lys Gln Met Ser Asp Arg Arg Glu Asn Asp Met Ser Pro Ser 
             180                185                190
Asn Asn Val Val Pro Ile His Val Pro Pro Thr Thr Glu Asn Lys Pro 
         195                200                205
Lys Val Gln Cys Cys Gln Asn Ile 
     210                215



<210> 3890
<211> 895
<212> DNA
<213> Rattus norvegicus
<308> M75153
<400> 3890

atgggcacc  gcgacgacg  gtacgacta  ctctttaaa  ttgtcctta  tggagattc  60
ggtgttggg  agagtaacc  cctgtctcg  tttactcgg  atgagttta  tctggaaag  120
aagagtacc  ttggagtag  atttgcaac  agaagcatc  aggttgatg  gaaaacaat  180
aaggcacag  tatgggaca  agcagggca  gagcggtac  gggctataa  gtctgcata  240
tatcgtgga  cagtaggtg  cttattggt  tatgacatt  ctaagcatc  cacatatga  300
aatgtagaa  gatggctga  agaactgag  gatcatgct  atagtaaca  tgttatcat  360
cttgtgggc  ataagagtg  tttacgtca  ctcagggca  ttcctacag  tgaagcaag  420
gcatttgca  agaagaatg  tttgtcgtt  attgagaca  ctgctctag  ttctacaaa  480
gttgaagct  cttttcaga  aattctaac  gagatatac  gcattgttt  tcagaagca  540
atgtcagac  gacgtgaaa  tgacatgtc  ccaagcaac  atgtggttc  tattcatgt  600
ccacccacc  ctgagaaca  gccaaaggt  cagtgctgt  agaacatct  aggcgcctc  660
ctcccctag  cggctgtgt  tagtccatt  cccaggtct  agatttaaa  atatttgta  720
ttcttgtgg  cactttctg  gttttatta  ttccttaca  ttaagaatc  tcccatgtc  780
taagtcttt  atttggctt  ataaaatcc  caactttgt  ctgaatgac  cgagttctt  840
ttcatgcta  ggcttctct  gccttagtt  aataaactg  atgtttgaa  tcctc  895



<210> 3891
<211> 216
<212> PRT
<213> Rattus norvegicus
<308> P24410
<400> 3891

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
  1               5                  10                  15
Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
             20                  25                  30
Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
         35                  40                  45
Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
     50                  55                  60
Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
 65                  70                  75                  80
Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                 85                  90                  95
Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
             100                105                110
Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
         115                120                125
Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
     130                135                140
Lys Asn Gly Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
 145                150                155                160
Val Glu Ala Ala Phe Gln Thr Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                 165                170                175
Ser Gln Lys Gln Met Ser Asp Arg Arg Glu Asn Asp Met Ser Pro Ser 
             180                185                190
Asn Asn Val Val Pro Ile His Val Pro Pro Thr Thr Glu Asn Lys Pro 
         195                200                205
Lys Val Gln Cys Cys Gln Asn Ile 
     210                215



<210> 3892
<211> 651
<212> DNA
<213> Homo sapiens
<308> X53143
<400> 3892

atgggcacc  gcgacgacg  gtacgacta  ctctttaaa  ttgtcctta  tggagattc  60
ggtgttgga  agagtaatc  cctgtctcg  tttactcga  atgagttta  tctggaaag  120
aagagcacc  ttggagtag  gtttgcaac  agaagcatc  aggttgatg  aaaaacaat  180
aaggcacag  tatgggaca  agcagggca  gagcgatat  gagctataa  atcagcata  240
tatcgtgga  ctgtaggtg  cttattggt  tatgacatt  ctaaacatc  cacatatga  300
aatgtagag  gatggctga  agaactgag  gatcatgct  atagtaaca  tgttatcat  360
cttgtgggc  ataagagtg  tctacgtca  ctcagggca  ttcctacag  tgaagcaag  420
gcttttgca  aaaagaatg  tttgtcatt  attgaaact  cggccctag  ctctacaaa  480
gtagaagct  cttttcaga  aattttaac  gagatttac  gcattgttt  tcagaagca  540
atgtcagac  gacgcgaaa  tgacatgtc  ccaagcaac  atgtggttc  tattcatgt  600
ccaccaacc  ctgaaaaca  gccaaaggt  cagtgctgt  agaacatct  a  651



<210> 3893
<211> 216
<212> PRT
<213> Homo sapiens
<308> P24410
<400> 3893

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
  1               5                  10                  15
Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
             20                  25                  30
Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
         35                  40                  45
Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
     50                  55                  60
Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
 65                  70                  75                  80
Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                 85                  90                  95
Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
             100                105                110
Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
         115                120                125
Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
     130                135                140
Lys Asn Gly Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
 145                150                155                160
Val Glu Ala Ala Phe Gln Thr Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                 165                170                175
Ser Gln Lys Gln Met Ser Asp Arg Arg Glu Asn Asp Met Ser Pro Ser 
             180                185                190
Asn Asn Val Val Pro Ile His Val Pro Pro Thr Thr Glu Asn Lys Pro 
         195                200                205
Lys Val Gln Cys Cys Gln Asn Ile 
     210                215



<210> 3894
<211> 1643
<212> DNA
<213> Rattus norvegicus
<308> M75168
<400> 3894

ccttgctgt  ctccaaccc  tctctttcc  cttgcttcc  ctcacctgc  ctgggactc  60
taactcaga  acctccctt  tccccccgc  ggctggatt  tggcagaga  cgatgtgga  120
aatgagctc  tggactatg  agacgatga  gtggagacg  ccgctgggg  agatgggac  180
gaagctccc  ccaagaaag  cgtcaaggg  tcctatgtc  ccatccaca  ctccggctt  240
cgagatttc  tacttaagc  agagttgct  cgggccatt  ttgactgtg  ctttgagca  300
ccatcagag  tccagcatg  atgcatccc  caggccatt  tggggatgg  tgtcctgtg  360
caggccaag  caggcatgg  aaaaacagc  gtgtttgtc  tggccacac  gcagcagct  420
gagccagtt  ctgggcagg  gtcagtgct  gtgatgtgt  acaccaggg  gctggcttt  480
cagatcagc  aggaatatg  gcgcttctc  aagtacatg  cgaatgtca  ggtggcagt  540
ttttttggc  gactgtcta  caagaagga  gaagaggtg  tgaagaaga  ctgcccaca  600
attgttgtg  ggactcctg  ccgaattct  gccctggcc  gaaataaga  cctgaacct  660
aaacacatt  aacacttta  cttggacga  tgtgacaag  tgcttgaac  gctcgacat  720
cgtcgggat  tccaggaaa  ttttcgcat  accccccat  agaagcagg  catgatgtt  780
agtgctacc  tgagcaaag  gatccgccc  gtgtgccgc  agttcatgc  agatcctat  840
gagatcttc  tggatgacg  gaccaagtt  acactgcac  ggttgcagc  atactacgt  900
aaactgaag  acaacgaga  gaaccggaa  ctctttgac  ttctcgatg  cctcgagtt  960
aaccaggtt  tgatctttg  gaagtccgt  cagcgctgc  tcgccttgg  ccagcttct  1020
gtggagcag  acttgccag  cattgctat  caccgcggg  tgccccagg  ggagaggct  1080
tctcggtat  agcagttca  ggattttca  cggaggata  ttgtggcta  caacctgtt  1140
ggccgtggc  tggacattg  gcgcgtgaa  atcgctttt  actatgaca  gccagagga  1200
tccgacacc  acctgcaca  ggtggccag  gcgggccgg  ttggcacca  gggcttggc  1260
tcacatttg  gtcagacga  aacgatgcc  agatcctga  tgacgtgca  gaccgtttc  1320
aggtcaaca  cagtgagct  cctgatgag  tcgacattt  ctcctacat  gaacagaca  1380
ggtagagga  tcacccatt  tggactgtg  cagtctgtg  agaagagga  gaaggggtc  1440
gggaggaaa  actactgcc  cacccctga  acctcagcc  accctctcc  tgcctctct  1500
tgcgtcacc  ccactccta  acctagtcc  gatttatca  agttgtttg  ttgtttgtt  1560
gtttttgtt  tttaacaaa  ctaagaatg  aaaaaaaaa  aaaaaaaaa  aaaaaaagt  1620
ccttctgag  cgaaaagaa  cag  1643



<210> 3895
<211> 428
<212> PRT
<213> Rattus norvegicus
<308> Q63413
<400> 3895

Met Ala Glu Asn Asp Val Asp Asn Glu Leu Leu Asp Tyr Glu Asp Asp 
  1               5                  10                  15
Glu Val Glu Thr Ala Ala Gly Ala Asp Gly Thr Glu Ala Pro Ala Lys 
             20                  25                  30
Lys Asp Val Lys Gly Ser Tyr Val Ser Ile His Ser Ser Gly Phe Arg 
         35                  40                  45
Asp Phe Leu Leu Lys Pro Glu Leu Leu Arg Ala Ile Val Asp Cys Gly 
     50                  55                  60
Phe Glu His Pro Ser Glu Val Gln His Glu Cys Ile Pro Gln Ala Ile 
 65                  70                  75                  80
Leu Gly Met Asp Val Leu Cys Gln Ala Lys Ser Gly Met Gly Lys Thr 
                 85                  90                  95
Ala Val Phe Val Leu Ala Thr Leu Gln Gln Leu Glu Pro Val Thr Gly 
             100                105                110
Gln Val Ser Val Leu Val Met Cys His Thr Arg Glu Leu Ala Phe Gln 
         115                120                125
Ile Ser Lys Glu Tyr Glu Arg Phe Ser Lys Tyr Met Pro Asn Val Lys 
     130                135                140
Val Ala Val Phe Phe Gly Gly Leu Ser Ile Lys Lys Asp Glu Glu Val 
 145                150                155                160
Leu Lys Lys Asn Cys Pro His Ile Val Val Gly Thr Pro Gly Arg Ile 
                 165                170                175
Leu Ala Leu Ala Arg Asn Lys Ser Leu Asn Leu Lys His Ile Lys His 
             180                185                190
Phe Ile Leu Asp Glu Cys Asp Lys Met Leu Glu Gln Leu Asp Met Arg 
         195                200                205
Arg Asp Val Gln Glu Ile Phe Arg Met Thr Pro His Glu Lys Gln Val 
     210                215                220
Met Met Phe Ser Ala Thr Leu Ser Lys Glu Ile Arg Pro Val Cys Arg 
 225                230                235                240
Lys Phe Met Gln Asp Pro Met Glu Ile Phe Val Asp Asp Glu Thr Lys 
                 245                250                255
Leu Thr Leu His Gly Leu Gln Gln Tyr Tyr Val Lys Leu Lys Asp Asn 
             260                265                270
Glu Lys Asn Arg Lys Leu Phe Asp Leu Leu Asp Val Leu Glu Phe Asn 
         275                280                285
Gln Val Val Ile Phe Val Lys Ser Val Gln Arg Cys Ile Ala Leu Ala 
     290                295                300
Gln Leu Leu Val Glu Gln Asn Leu Pro Ala Ile Ala Ile His Arg Gly 
 305                310                315                320
Met Pro Gln Glu Glu Arg Leu Ser Arg Tyr Gln Gln Phe Lys Asp Phe 
                 325                330                335
Gln Arg Arg Ile Leu Val Ala Thr Asn Leu Phe Gly Arg Gly Met Asp 
             340                345                350
Ile Val Arg Val Asn Ile Ala Phe Asn Tyr Asp Met Pro Glu Asp Ser 
         355                360                365
Asp Thr Tyr Leu His Arg Val Ala Arg Ala Gly Arg Phe Gly Thr Lys 
     370                375                380
Gly Leu Ala Ile Thr Phe Val Ser Asp Glu Asn Asp Ala Lys Ile Leu 
 385                390                395                400
Asn Asp Val Gln Asp Arg Phe Glu Val Asn Ile Ser Glu Leu Pro Asp 
                 405                410                415
Glu Ile Asp Ile Ser Ser Tyr Ile Glu Gln Thr Arg 
             420                425



<210> 3896
<211> 1978
<212> DNA
<213> Homo sapiens
<308> AK026762
<400> 3896

cactgtgct  tgcgagccg  atcatggat  acactgaca  tgagttaca  ggcactaat  60
gttctggat  cttgggtgg  cttgatgtt  gcagacgaa  tcctataaa  ctcatctcc  120
aacaagcaa  caaagcgaa  cctgcaccg  gaactcaaa  aactataaa  aggatgcct  180
caaaggctc  acctggtga  gaagaagga  ttgattata  tgaagaaga  cggtatgac  240
gtaaagggg  tgagctgtt  gcaaatcag  gaagatttc  tggacacct  ttttgggac  300
ttcagataa  catcttagg  gaaaaggat  atacaccag  tcatttctg  gacaagtgt  360
gattgccta  taaaatcta  gggagaatg  ttccatgca  gcatgtttt  tgctatgac  420
gtgctattt  acatgaaaa  aagggagat  agatgtgtc  aggctgtag  gatcctgtg  480
agcgaattg  gcagtgtac  cgaggttct  tcttcatgt  tagcattgt  caagggtgc  540
agagaacat  tttgtctca  agagactta  aggctcata  caaccatcg  catatgaga  600
ctggaaaac  tgttacccg  gcttcactt  aaaatgttc  tcctcctat  gccccacca  660
caactgaaa  ccctgagcg  tttataatg  caccagaca  gcaccatat  agccatatt  720
cgccaaagc  gcatatcat  atgccacca  ctcctttgc  acatgtgcc  catgagcac  780
ataatcagc  acatgagga  attcgtgct  ctccagcag  attgtccat  gctccacct  840
cacctcgat  ggtcagtca  gaaaccttt  gtatttcaa  aagaaaaca  agcaattta  900
taaccgtcc  tattcagga  gactcaaat  caggtgcta  agaaccacc  cctcctgcc  960
cagcacctg  tcaccatca  cctgaatat  agggtcaac  agtggtatc  caccctcat  1020
atattatgc  tccacagca  cattatgca  cacccccac  tcctccacc  ccaataagc  1080
atccaatgc  acatcctcc  caggctgca  gtactcctc  cttggtata  agccaagct  1140
cacctccac  aatgacctc  gctccacca  caataaccc  tccccctgg  catattatt  1200
cccagatgc  accttatat  aatcatcct  ctccaggac  tcccccgcc  caacatggt  1260
gtccacctg  aactgcacc  cctcctcac  attataatc  taactcatt  ccccagttc  1320
ctgaagatc  aggaactcc  agccctcca  ttacacaac  agggggaat  agtcctggt  1380
tatggcctg  accaagagg  ccaccacca  ctccacgat  gcagggtcc  ccttctcaa  1440
ccccacttc  tggaccaca  catccagat  agacaagat  tagaccgta  taccaatga  1500
aatagtatt  tgaatggaa  atatgaggg  gaaaaaaac  tatgtgtag  caatctttt  1560
agctttgac  gttttggga  ggaagagta  ctcttatcg  ggtagtata  aacacatag  1620
gtcttgttt  ttaaaatgg  tttaaatct  gaccttaag  ttgatttca  gtaccatac  1680
gtagtacag  taagtggct  agttgagca  agctatatt  taacatctc  ttgttcccc  1740
agtttagta  attgaccca  aggtgacca  ttgtaaaaa  tttgaaaaa  tttttcatt  1800
ttttacttc  gaagtattg  tttgttaaa  ccaacgttt  gtttttctt  tgatacatt  1860
tgttaacct  tgtaaaagg  ttaaatttc  atatggttg  aaaaaaaaa  aaaaaaaaa  1920
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  1978



<210> 3897
<211> 428
<212> PRT
<213> Homo sapiens
<308> NP_004631
<400> 3897

Met Ala Glu Asn Asp Val Asp Asn Glu Leu Leu Asp Tyr Glu Asp Asp 
  1               5                  10                  15
Glu Val Glu Thr Ala Ala Gly Gly Asp Gly Ala Glu Ala Pro Ala Lys 
             20                  25                  30
Lys Asp Val Lys Gly Ser Tyr Val Ser Ile His Ser Ser Gly Phe Arg 
         35                  40                  45
Asp Phe Leu Leu Lys Pro Glu Leu Leu Arg Ala Ile Val Asp Cys Gly 
     50                  55                  60
Phe Glu His Pro Ser Glu Val Gln His Glu Cys Ile Pro Gln Ala Ile 
 65                  70                  75                  80
Leu Gly Met Asp Val Leu Cys Gln Ala Lys Ser Gly Met Gly Lys Thr 
                 85                  90                  95
Ala Val Phe Val Leu Ala Thr Leu Gln Gln Leu Glu Pro Val Thr Gly 
             100                105                110
Gln Val Ser Val Leu Val Met Cys His Thr Arg Glu Leu Ala Phe Gln 
         115                120                125
Ile Ser Lys Glu Tyr Glu Arg Phe Ser Lys Tyr Met Pro Asn Val Lys 
     130                135                140
Val Ala Val Phe Phe Gly Gly Leu Ser Ile Lys Lys Asp Glu Glu Val 
 145                150                155                160
Leu Lys Lys Asn Cys Pro His Ile Val Val Gly Thr Pro Gly Arg Ile 
                 165                170                175
Leu Ala Leu Ala Arg Asn Lys Ser Leu Asn Leu Lys His Ile Lys His 
             180                185                190
Phe Ile Leu Asp Glu Cys Asp Lys Met Leu Glu Gln Leu Asp Met Arg 
         195                200                205
Arg Asp Val Gln Glu Ile Phe Arg Met Thr Pro His Glu Lys Gln Val 
     210                215                220
Met Met Phe Ser Ala Thr Leu Ser Lys Glu Ile Arg Pro Val Cys Arg 
 225                230                235                240
Lys Phe Met Gln Asp Pro Met Glu Ile Phe Val Asp Asp Glu Thr Lys 
                 245                250                255
Leu Thr Leu His Gly Leu Gln Gln Tyr Tyr Val Lys Leu Lys Asp Asn 
             260                265                270
Glu Lys Asn Arg Lys Leu Phe Asp Leu Leu Asp Val Leu Glu Phe Asn 
         275                280                285
Gln Val Val Ile Phe Val Lys Ser Val Gln Arg Cys Ile Ala Leu Ala 
     290                295                300
Gln Leu Leu Val Glu Gln Asn Phe Pro Ala Ile Ala Ile His Arg Gly 
 305                310                315                320
Met Pro Gln Glu Glu Arg Leu Ser Arg Tyr Gln Gln Phe Lys Asp Phe 
                 325                330                335
Gln Arg Arg Ile Leu Val Ala Thr Asn Leu Phe Gly Arg Gly Met Asp 
             340                345                350
Ile Glu Arg Val Asn Ile Ala Phe Asn Tyr Asp Met Pro Glu Asp Ser 
         355                360                365
Asp Thr Tyr Leu His Arg Val Ala Arg Ala Gly Arg Phe Gly Thr Lys 
     370                375                380
Gly Leu Ala Ile Thr Phe Val Ser Asp Glu Asn Asp Ala Lys Ile Leu 
 385                390                395                400
Asn Asp Val Gln Asp Arg Phe Glu Val Asn Ile Ser Glu Leu Pro Asp 
                 405                410                415
Glu Ile Asp Ile Ser Ser Tyr Ile Glu Gln Thr Arg 
             420                425



<210> 3898
<211> 1643
<212> DNA
<213> Rattus norvegicus
<308> M75168
<400> 3898

ccttgctgt  ctccaaccc  tctctttcc  cttgcttcc  ctcacctgc  ctgggactc  60
taactcaga  acctccctt  tccccccgc  ggctggatt  tggcagaga  cgatgtgga  120
aatgagctc  tggactatg  agacgatga  gtggagacg  ccgctgggg  agatgggac  180
gaagctccc  ccaagaaag  cgtcaaggg  tcctatgtc  ccatccaca  ctccggctt  240
cgagatttc  tacttaagc  agagttgct  cgggccatt  ttgactgtg  ctttgagca  300
ccatcagag  tccagcatg  atgcatccc  caggccatt  tggggatgg  tgtcctgtg  360
caggccaag  caggcatgg  aaaaacagc  gtgtttgtc  tggccacac  gcagcagct  420
gagccagtt  ctgggcagg  gtcagtgct  gtgatgtgt  acaccaggg  gctggcttt  480
cagatcagc  aggaatatg  gcgcttctc  aagtacatg  cgaatgtca  ggtggcagt  540
ttttttggc  gactgtcta  caagaagga  gaagaggtg  tgaagaaga  ctgcccaca  600
attgttgtg  ggactcctg  ccgaattct  gccctggcc  gaaataaga  cctgaacct  660
aaacacatt  aacacttta  cttggacga  tgtgacaag  tgcttgaac  gctcgacat  720
cgtcgggat  tccaggaaa  ttttcgcat  accccccat  agaagcagg  catgatgtt  780
agtgctacc  tgagcaaag  gatccgccc  gtgtgccgc  agttcatgc  agatcctat  840
gagatcttc  tggatgacg  gaccaagtt  acactgcac  ggttgcagc  atactacgt  900
aaactgaag  acaacgaga  gaaccggaa  ctctttgac  ttctcgatg  cctcgagtt  960
aaccaggtt  tgatctttg  gaagtccgt  cagcgctgc  tcgccttgg  ccagcttct  1020
gtggagcag  acttgccag  cattgctat  caccgcggg  tgccccagg  ggagaggct  1080
tctcggtat  agcagttca  ggattttca  cggaggata  ttgtggcta  caacctgtt  1140
ggccgtggc  tggacattg  gcgcgtgaa  atcgctttt  actatgaca  gccagagga  1200
tccgacacc  acctgcaca  ggtggccag  gcgggccgg  ttggcacca  gggcttggc  1260
tcacatttg  gtcagacga  aacgatgcc  agatcctga  tgacgtgca  gaccgtttc  1320
aggtcaaca  cagtgagct  cctgatgag  tcgacattt  ctcctacat  gaacagaca  1380
ggtagagga  tcacccatt  tggactgtg  cagtctgtg  agaagagga  gaaggggtc  1440
gggaggaaa  actactgcc  cacccctga  acctcagcc  accctctcc  tgcctctct  1500
tgcgtcacc  ccactccta  acctagtcc  gatttatca  agttgtttg  ttgtttgtt  1560
gtttttgtt  tttaacaaa  ctaagaatg  aaaaaaaaa  aaaaaaaaa  aaaaaaagt  1620
ccttctgag  cgaaaagaa  cag  1643



<210> 3899
<211> 428
<212> PRT
<213> Rattus norvegicus
<308> Q63413
<400> 3899

Met Ala Glu Asn Asp Val Asp Asn Glu Leu Leu Asp Tyr Glu Asp Asp 
  1               5                  10                  15
Glu Val Glu Thr Ala Ala Gly Ala Asp Gly Thr Glu Ala Pro Ala Lys 
             20                  25                  30
Lys Asp Val Lys Gly Ser Tyr Val Ser Ile His Ser Ser Gly Phe Arg 
         35                  40                  45
Asp Phe Leu Leu Lys Pro Glu Leu Leu Arg Ala Ile Val Asp Cys Gly 
     50                  55                  60
Phe Glu His Pro Ser Glu Val Gln His Glu Cys Ile Pro Gln Ala Ile 
 65                  70                  75                  80
Leu Gly Met Asp Val Leu Cys Gln Ala Lys Ser Gly Met Gly Lys Thr 
                 85                  90                  95
Ala Val Phe Val Leu Ala Thr Leu Gln Gln Leu Glu Pro Val Thr Gly 
             100                105                110
Gln Val Ser Val Leu Val Met Cys His Thr Arg Glu Leu Ala Phe Gln 
         115                120                125
Ile Ser Lys Glu Tyr Glu Arg Phe Ser Lys Tyr Met Pro Asn Val Lys 
     130                135                140
Val Ala Val Phe Phe Gly Gly Leu Ser Ile Lys Lys Asp Glu Glu Val 
 145                150                155                160
Leu Lys Lys Asn Cys Pro His Ile Val Val Gly Thr Pro Gly Arg Ile 
                 165                170                175
Leu Ala Leu Ala Arg Asn Lys Ser Leu Asn Leu Lys His Ile Lys His 
             180                185                190
Phe Ile Leu Asp Glu Cys Asp Lys Met Leu Glu Gln Leu Asp Met Arg 
         195                200                205
Arg Asp Val Gln Glu Ile Phe Arg Met Thr Pro His Glu Lys Gln Val 
     210                215                220
Met Met Phe Ser Ala Thr Leu Ser Lys Glu Ile Arg Pro Val Cys Arg 
 225                230                235                240
Lys Phe Met Gln Asp Pro Met Glu Ile Phe Val Asp Asp Glu Thr Lys 
                 245                250                255
Leu Thr Leu His Gly Leu Gln Gln Tyr Tyr Val Lys Leu Lys Asp Asn 
             260                265                270
Glu Lys Asn Arg Lys Leu Phe Asp Leu Leu Asp Val Leu Glu Phe Asn 
         275                280                285
Gln Val Val Ile Phe Val Lys Ser Val Gln Arg Cys Ile Ala Leu Ala 
     290                295                300
Gln Leu Leu Val Glu Gln Asn Leu Pro Ala Ile Ala Ile His Arg Gly 
 305                310                315                320
Met Pro Gln Glu Glu Arg Leu Ser Arg Tyr Gln Gln Phe Lys Asp Phe 
                 325                330                335
Gln Arg Arg Ile Leu Val Ala Thr Asn Leu Phe Gly Arg Gly Met Asp 
             340                345                350
Ile Val Arg Val Asn Ile Ala Phe Asn Tyr Asp Met Pro Glu Asp Ser 
         355                360                365
Asp Thr Tyr Leu His Arg Val Ala Arg Ala Gly Arg Phe Gly Thr Lys 
     370                375                380
Gly Leu Ala Ile Thr Phe Val Ser Asp Glu Asn Asp Ala Lys Ile Leu 
 385                390                395                400
Asn Asp Val Gln Asp Arg Phe Glu Val Asn Ile Ser Glu Leu Pro Asp 
                 405                410                415
Glu Ile Asp Ile Ser Ser Tyr Ile Glu Gln Thr Arg 
             420                425



<210> 3900
<211> 1978
<212> DNA
<213> Homo sapiens
<308> AK026762
<400> 3900

cactgtgct  tgcgagccg  atcatggat  acactgaca  tgagttaca  ggcactaat  60
gttctggat  cttgggtgg  cttgatgtt  gcagacgaa  tcctataaa  ctcatctcc  120
aacaagcaa  caaagcgaa  cctgcaccg  gaactcaaa  aactataaa  aggatgcct  180
caaaggctc  acctggtga  gaagaagga  ttgattata  tgaagaaga  cggtatgac  240
gtaaagggg  tgagctgtt  gcaaatcag  gaagatttc  tggacacct  ttttgggac  300
ttcagataa  catcttagg  gaaaaggat  atacaccag  tcatttctg  gacaagtgt  360
gattgccta  taaaatcta  gggagaatg  ttccatgca  gcatgtttt  tgctatgac  420
gtgctattt  acatgaaaa  aagggagat  agatgtgtc  aggctgtag  gatcctgtg  480
agcgaattg  gcagtgtac  cgaggttct  tcttcatgt  tagcattgt  caagggtgc  540
agagaacat  tttgtctca  agagactta  aggctcata  caaccatcg  catatgaga  600
ctggaaaac  tgttacccg  gcttcactt  aaaatgttc  tcctcctat  gccccacca  660
caactgaaa  ccctgagcg  tttataatg  caccagaca  gcaccatat  agccatatt  720
cgccaaagc  gcatatcat  atgccacca  ctcctttgc  acatgtgcc  catgagcac  780
ataatcagc  acatgagga  attcgtgct  ctccagcag  attgtccat  gctccacct  840
cacctcgat  ggtcagtca  gaaaccttt  gtatttcaa  aagaaaaca  agcaattta  900
taaccgtcc  tattcagga  gactcaaat  caggtgcta  agaaccacc  cctcctgcc  960
cagcacctg  tcaccatca  cctgaatat  agggtcaac  agtggtatc  caccctcat  1020
atattatgc  tccacagca  cattatgca  cacccccac  tcctccacc  ccaataagc  1080
atccaatgc  acatcctcc  caggctgca  gtactcctc  cttggtata  agccaagct  1140
cacctccac  aatgacctc  gctccacca  caataaccc  tccccctgg  catattatt  1200
cccagatgc  accttatat  aatcatcct  ctccaggac  tcccccgcc  caacatggt  1260
gtccacctg  aactgcacc  cctcctcac  attataatc  taactcatt  ccccagttc  1320
ctgaagatc  aggaactcc  agccctcca  ttacacaac  agggggaat  agtcctggt  1380
tatggcctg  accaagagg  ccaccacca  ctccacgat  gcagggtcc  ccttctcaa  1440
ccccacttc  tggaccaca  catccagat  agacaagat  tagaccgta  taccaatga  1500
aatagtatt  tgaatggaa  atatgaggg  gaaaaaaac  tatgtgtag  caatctttt  1560
agctttgac  gttttggga  ggaagagta  ctcttatcg  ggtagtata  aacacatag  1620
gtcttgttt  ttaaaatgg  tttaaatct  gaccttaag  ttgatttca  gtaccatac  1680
gtagtacag  taagtggct  agttgagca  agctatatt  taacatctc  ttgttcccc  1740
agtttagta  attgaccca  aggtgacca  ttgtaaaaa  tttgaaaaa  tttttcatt  1800
ttttacttc  gaagtattg  tttgttaaa  ccaacgttt  gtttttctt  tgatacatt  1860
tgttaacct  tgtaaaagg  ttaaatttc  atatggttg  aaaaaaaaa  aaaaaaaaa  1920
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  1978



<210> 3901
<211> 428
<212> PRT
<213> Homo sapiens
<308> NP_004631
<400> 3901

Met Ala Glu Asn Asp Val Asp Asn Glu Leu Leu Asp Tyr Glu Asp Asp 
  1               5                  10                  15
Glu Val Glu Thr Ala Ala Gly Gly Asp Gly Ala Glu Ala Pro Ala Lys 
             20                  25                  30
Lys Asp Val Lys Gly Ser Tyr Val Ser Ile His Ser Ser Gly Phe Arg 
         35                  40                  45
Asp Phe Leu Leu Lys Pro Glu Leu Leu Arg Ala Ile Val Asp Cys Gly 
     50                  55                  60
Phe Glu His Pro Ser Glu Val Gln His Glu Cys Ile Pro Gln Ala Ile 
 65                  70                  75                  80
Leu Gly Met Asp Val Leu Cys Gln Ala Lys Ser Gly Met Gly Lys Thr 
                 85                  90                  95
Ala Val Phe Val Leu Ala Thr Leu Gln Gln Leu Glu Pro Val Thr Gly 
             100                105                110
Gln Val Ser Val Leu Val Met Cys His Thr Arg Glu Leu Ala Phe Gln 
         115                120                125
Ile Ser Lys Glu Tyr Glu Arg Phe Ser Lys Tyr Met Pro Asn Val Lys 
     130                135                140
Val Ala Val Phe Phe Gly Gly Leu Ser Ile Lys Lys Asp Glu Glu Val 
 145                150                155                160
Leu Lys Lys Asn Cys Pro His Ile Val Val Gly Thr Pro Gly Arg Ile 
                 165                170                175
Leu Ala Leu Ala Arg Asn Lys Ser Leu Asn Leu Lys His Ile Lys His 
             180                185                190
Phe Ile Leu Asp Glu Cys Asp Lys Met Leu Glu Gln Leu Asp Met Arg 
         195                200                205
Arg Asp Val Gln Glu Ile Phe Arg Met Thr Pro His Glu Lys Gln Val 
     210                215                220
Met Met Phe Ser Ala Thr Leu Ser Lys Glu Ile Arg Pro Val Cys Arg 
 225                230                235                240
Lys Phe Met Gln Asp Pro Met Glu Ile Phe Val Asp Asp Glu Thr Lys 
                 245                250                255
Leu Thr Leu His Gly Leu Gln Gln Tyr Tyr Val Lys Leu Lys Asp Asn 
             260                265                270
Glu Lys Asn Arg Lys Leu Phe Asp Leu Leu Asp Val Leu Glu Phe Asn 
         275                280                285
Gln Val Val Ile Phe Val Lys Ser Val Gln Arg Cys Ile Ala Leu Ala 
     290                295                300
Gln Leu Leu Val Glu Gln Asn Phe Pro Ala Ile Ala Ile His Arg Gly 
 305                310                315                320
Met Pro Gln Glu Glu Arg Leu Ser Arg Tyr Gln Gln Phe Lys Asp Phe 
                 325                330                335
Gln Arg Arg Ile Leu Val Ala Thr Asn Leu Phe Gly Arg Gly Met Asp 
             340                345                350
Ile Glu Arg Val Asn Ile Ala Phe Asn Tyr Asp Met Pro Glu Asp Ser 
         355                360                365
Asp Thr Tyr Leu His Arg Val Ala Arg Ala Gly Arg Phe Gly Thr Lys 
     370                375                380
Gly Leu Ala Ile Thr Phe Val Ser Asp Glu Asn Asp Ala Lys Ile Leu 
 385                390                395                400
Asn Asp Val Gln Asp Arg Phe Glu Val Asn Ile Ser Glu Leu Pro Asp 
                 405                410                415
Glu Ile Asp Ile Ser Ser Tyr Ile Glu Gln Thr Arg 
             420                425



<210> 3902
<211> 2819
<212> DNA
<213> Rattus norvegicus
<308> M76426
<400> 3902

gctcagcac  caggcgact  gactcgcga  tggcgcgga  cggcagggc  cgtcttttt  60
ctttctcca  cgcctcctt  tcccccctt  tcccttttc  gttggaggg  gtggggaga  120
gaaagagag  cagagagaa  ggaaatttt  tttttccga  gcatcctaa  cagtgagct  180
gcgcagagc  gcggcccat  gcttcgctg  accaaaggt  caccggcaa  atcaacacc  240
cgcgctcct  cccggcgcc  ccggaggcc  gtcaccttc  gggtggcca  gggccggag  300
aggacgccg  ctcgaagcc  ctcgggccg  aggcgcagg  ggtggcacc  cgggagcgc  360
gcggtgctg  tggccggcc  cggttccag  accaggcgc  gagcgactg  gacgaggag  420
acgagctgg  ggggagtaa  cctccacag  gaaactgga  aggaatcgc  attgcactg  480
ttgtcatcc  tgtcatctg  tccctgatt  tcacctcag  catcctgct  accccagcg  540
aagatacca  tctgtctca  aagaagaag  tgactgtgg  agatctttt  agtgaagac  600
tcaaaatcc  tgacccaga  gcaaagtgg  taagcgata  ggaattcat  tacagagaa  660
ggaaaggga  cgtcatact  cggaacgtt  agacaaata  ttccacggt  ttaatagaa  720
gcaaaaaaa  tgaatcgtt  agagccatc  gatatgaaa  atccccaga  aaagagtat  780
cgttgtttt  ctataatgt  gaaccggta  accaacact  ccacactgg  tattatgtt  840
tgagcaaaa  tcctcacgg  gaccctcag  gtctggacc  accagaagt  agcaacgcg  900
agcttcagt  tgcagggtg  ggcccgaaa  gccagcagc  gatatttat  tttgagaac  960
acatctact  ctgtgccca  gttggaaag  aggcgattc  agtggtctc  acggggaag  1020
agggtgtga  ctacaatgg  ctcagcgac  ggctgtatg  agaggagat  ctgaagagc  1080
acatcgcac  ttggtggtc  ccagatggt  caaggctcg  ctatgccac  atcaatgat  1140
cccgagttc  acttatgga  ctgccaacc  acacgggct  tgtctaccc  actgtgaag  1200
cctaccact  tcctaaggc  ggcagtgaa  accccagca  ctccctcca  gtcatcggc  1260
tgaatggac  cacccacga  ctggagatg  tgccacctg  cgacccccg  atgagagag  1320
attacatca  catggtgaa  tgggccacc  gcaccaagg  tgctgtgac  tggctgaac  1380
gggcccaga  tgtgtccat  ctgaccctc  gtgatgcca  cacaggtgt  tgcactaag  1440
aacacgagg  tgaaagtga  gcttggctc  acagacaga  tgaagagcc  gtgttctcc  1500
aggatggcc  gaagttttt  tttgtcaga  cgatcccac  gggaggccg  ggtaaattc  1560
accacatca  tgtatcctc  tcccagccc  acagcagca  tgacaacat  cagtccatt  1620
cctctgggg  ctgggatgt  accgagatc  tgacctacg  tgagaagcg  aataagctc  1680
atttcctaa  cacagagga  ctgccacga  gacgacacc  ctacagcgc  aacacggta  1740
acgacttca  caggcagtg  ctgtcatgt  acctggtgg  gaactgcac  tatgtcagt  1800
cttccttca  tcataacat  gacttcttc  tgctcaagt  tgaaggccc  ggcgtaccc  1860
ctgttactg  gcacaatac  acggataag  gaagaatgt  tgacttgga  gcaaatgag  1920
aagtgcaga  agccatcta  gatcggcag  tgcctaaaa  tgaataccg  aaaattgaa  1980
tggaagatt  cagcttgcc  atgcaaatc  tgaagccgg  caccttcac  gacacagcc  2040
actaccctt  attgctcgt  gtggatggt  ctccaggga  tcagagcgt  tcagagagg  2100
ttgaagtga  ctgggagac  gtgttggtg  gcagccatg  agcagtggt  gtcaagtgt  2160
acggccgag  cagcggctt  cagggaacc  agctcttgc  cgaagtacg  aggcggcta  2220
gcttcctgg  ggagaagga  cagatggaa  ctgtgagaa  catgctgaa  gagcagtac  2280
ttgacaaga  tcgggtagc  gtgtttggg  aggattatg  tgggtacct  agtacttac  2340
tcctcccag  caagggaga  aaccaaggc  agactttca  ctgcggctc  gcactctct  2400
cgataacgg  cttcaaact  tatgcctca  cattttccg  gaggtacct  ggcctccat  2460
gactcgaca  cagagcgta  gagatgacc  agctggcac  cagagtgtc  gcactggag  2520
accagcagt  cctgatcat  catgctacg  ctgacgaaa  aatccattt  cagcacaca  2580
cagagctca  cacgcagct  atcaaggga  aggccaatt  cagcttaca  atataccca  2640
atgaaagtc  ctactttca  agcgtggcg  tcaaacagc  cctgtacag  tccatcatc  2700
gattctttg  ggaatgttt  aggatccag  acaagctac  tacagccac  gcgaaagag  2760
acgaggagg  ggactaacc  cgcttgaga  ctaaacaca  acatggctc  ttctacaac  2819



<210> 3903
<211> 859
<212> PRT
<213> Rattus norvegicus
<308> P46101
<400> 3903

Met Ala Ser Leu Tyr Gln Arg Phe Thr Gly Lys Ile Asn Thr Ser Arg 
  1               5                  10                  15
Ser Phe Pro Ala Pro Pro Glu Ala Ser His Leu Leu Gly Gly Gln Gly 
             20                  25                  30
Pro Glu Glu Asp Ala Gly Ser Lys Pro Leu Gly Pro Gln Ala Gln Ala 
         35                  40                  45
Val Ala Pro Arg Glu Arg Gly Gly Ala Gly Gly Arg Pro Arg Phe Gln 
     50                  55                  60
Tyr Gln Ala Arg Ser Asp Cys Asp Glu Glu Asp Glu Leu Val Gly Ser 
 65                  70                  75                  80
Asn Pro Pro Gln Arg Asn Trp Lys Gly Ile Ala Ile Ala Leu Leu Val 
                 85                  90                  95
Ile Leu Val Ile Cys Ser Leu Ile Val Thr Ser Val Ile Leu Leu Thr 
             100                105                110
Pro Ala Glu Asp Thr Ser Leu Ser Gln Lys Lys Lys Val Thr Val Glu 
         115                120                125
Asp Leu Phe Ser Glu Asp Phe Lys Ile His Asp Pro Glu Ala Lys Trp 
     130                135                140
Ile Ser Asp Lys Glu Phe Ile Tyr Arg Glu Arg Lys Gly Ser Val Ile 
 145                150                155                160
Leu Arg Asn Val Glu Thr Asn Asn Ser Thr Val Leu Ile Glu Gly Lys 
                 165                170                175
Lys Ile Glu Ser Leu Arg Ala Ile Arg Tyr Glu Ile Ser Pro Asp Lys 
             180                185                190
Glu Tyr Ala Leu Phe Ser Tyr Asn Val Glu Pro Val Tyr Gln His Ser 
         195                200                205
His Thr Gly Tyr Tyr Val Leu Ser Lys Ile Pro His Gly Asp Pro Gln 
     210                215                220
Ser Leu Asp Pro Pro Glu Val Ser Asn Ala Lys Leu Gln Tyr Ala Gly 
 225                230                235                240
Trp Gly Pro Lys Gly Gln Gln Leu Ile Phe Ile Phe Glu Asn Asn Ile 
                 245                250                255
Tyr Tyr Cys Ala His Val Gly Lys Gln Ala Ile Arg Val Val Ser Thr 
             260                265                270
Gly Lys Glu Gly Val Ile Tyr Asn Gly Leu Ser Asp Trp Leu Tyr Glu 
         275                280                285
Glu Glu Ile Leu Lys Ser His Ile Ala His Trp Trp Ser Pro Asp Gly 
     290                295                300
Thr Arg Leu Ala Tyr Ala Thr Ile Asn Asp Ser Arg Val Pro Leu Met 
 305                310                315                320
Glu Leu Pro Thr Tyr Thr Gly Ser Val Tyr Pro Thr Val Lys Pro Tyr 
                 325                330                335
His Tyr Pro Lys Ala Gly Ser Glu Asn Pro Ser Ile Ser Leu His Val 
             340                345                350
Ile Gly Leu Asn Gly Pro Thr His Asp Leu Glu Met Met Pro Pro Asp 
         355                360                365
Asp Pro Arg Met Arg Glu Tyr Tyr Ile Thr Met Val Lys Trp Ala Thr 
     370                375                380
Ser Thr Lys Val Ala Val Thr Trp Leu Asn Arg Ala Gln Asn Val Ser 
 385                390                395                400
Ile Leu Thr Leu Cys Asp Ala Thr Thr Gly Val Cys Thr Lys Lys His 
                 405                410                415
Glu Asp Glu Ser Glu Ala Trp Leu His Arg Gln Asn Glu Glu Pro Val 
             420                425                430
Phe Ser Lys Asp Gly Arg Lys Phe Phe Phe Val Arg Ala Ile Pro Gln 
         435                440                445
Gly Gly Arg Gly Lys Phe Tyr His Ile Thr Val Ser Ser Ser Gln Pro 
     450                455                460
Asn Ser Ser Asn Asp Asn Ile Gln Ser Ile Thr Ser Gly Asp Trp Asp 
 465                470                475                480
Val Thr Glu Ile Leu Thr Tyr Asp Glu Lys Arg Asn Lys Leu Tyr Phe 
                 485                490                495
Leu Ser Thr Glu Asp Leu Pro Arg Arg Arg His Leu Tyr Ser Ala Asn 
             500                505                510
Thr Val Asp Asp Phe Asn Arg Gln Cys Leu Ser Cys Asp Leu Val Glu 
         515                520                525
Asn Cys Thr Tyr Val Ser Ala Ser Phe Ser His Asn Met Asp Phe Phe 
     530                535                540
Leu Leu Lys Cys Glu Gly Pro Gly Val Pro Thr Val Thr Val His Asn 
 545                550                555                560
Thr Thr Asp Lys Arg Arg Met Phe Asp Leu Glu Ala Asn Glu Gln Val 
                 565                570                575
Gln Lys Ala Ile Tyr Asp Arg Gln Met Pro Lys Ile Glu Tyr Arg Lys 
             580                585                590
Ile Glu Val Glu Asp Tyr Ser Leu Pro Met Gln Ile Leu Lys Pro Ala 
         595                600                605
Thr Phe Thr Asp Thr Ala His Tyr Pro Leu Leu Leu Val Val Asp Gly 
     610                615                620
Thr Pro Gly Ser Gln Ser Val Ser Glu Arg Phe Glu Val Thr Trp Glu 
 625                630                635                640
Thr Val Leu Val Ser Ser His Gly Ala Val Val Val Lys Cys Asp Gly 
                 645                650                655
Arg Gly Ser Gly Phe Gln Gly Thr Lys Leu Leu His Glu Val Arg Arg 
             660                665                670
Arg Leu Gly Phe Leu Glu Glu Lys Asp Gln Met Glu Ala Val Arg Thr 
         675                680                685
Met Leu Lys Glu Gln Tyr Ile Asp Lys Thr Arg Val Ala Val Phe Gly 
     690                695                700
Lys Asp Tyr Gly Gly Tyr Leu Ser Thr Tyr Ile Leu Pro Ala Lys Gly 
 705                710                715                720
Glu Asn Gln Gly Gln Thr Phe Thr Cys Gly Ser Ala Leu Ser Pro Ile 
                 725                730                735
Thr Asp Phe Lys Leu Tyr Ala Ser Ala Phe Ser Glu Arg Tyr Leu Gly 
             740                745                750
Leu His Gly Leu Asp Asn Arg Ala Tyr Glu Met Thr Lys Leu Ala His 
         755                760                765
Arg Val Ser Ala Leu Glu Asp Gln Gln Phe Leu Ile Ile His Ala Thr 
     770                775                780
Ala Asp Glu Lys Ile His Phe Gln His Thr Ala Glu Leu Ile Thr Gln 
 785                790                795                800
Leu Ile Lys Gly Lys Ala Asn Tyr Ser Leu Gln Ile Tyr Pro Asp Glu 
                 805                810                815
Ser His Tyr Phe His Ser Val Ala Leu Lys Gln His Leu Tyr Arg Ser 
             820                825                830
Ile Ile Gly Phe Phe Val Glu Cys Phe Arg Ile Gln Asp Lys Leu Pro 
         835                840                845
Thr Ala Thr Ala Lys Glu Asp Glu Glu Glu Asp 
     850                855



<210> 3904
<211> 3556
<212> DNA
<213> Homo sapiens
<308> M96860
<400> 3904

agcaaactc  tcttgtcta  ccaccctcc  tcccccatc  tccccaaaa  agccttgtg  60
tttcggaag  atggactaa  atcacactc  tccttacct  accgcttgg  ctctggtgg  120
tcccaactc  ccgtcagac  ccacctgcc  cggtggtgg  aagcgcctg  acagaccat  180
accacagcc  aggagccaa  cgcttcggg  aaatccgtg  agcagcagg  acaggagct  240
gtggggagt  accctccgc  gaggaattg  aaaggaata  caattgcac  gcttgtcat  300
ctggtcatc  gctccttga  cgtcacctc  gtcatactt  tgacaccag  ggaagataa  360
agtctgtct  aaaagaaga  ggtcactgt  gaagatctc  tcagtgaag  cttcaaaat  420
catgacccc  aggctaagt  gataagtga  acagaattc  tctacagag  acagaaagg  480
acagtgaga  tgtggaatg  tgaaacaaa  acttctact  tcttaatag  aggcaaaaa  540
attgaatca  taagagcca  cagatatga  atatctcca  atagagagt  tgcactttt  600
tcatacaat  tggaaccca  atatcaaca  tcgtatact  gatattatg  cctgagcaa  660
attcctcat  gggatcctc  aagtctgga  ccaccagaa  tcagcaatg  aaagcttca  720
tatgcagga  ggggcccta  aggccaaca  ctgatattt  tttttgaaa  caatatcta  780
tactgtgca  atgtcggga  acaggccat  cgtgtggtc  ccactggca  ggaaggtgt  840
atttacaat  gcctcagtg  ctggctgta  gaagaggag  ttttgaaga  acacatcgc  900
cactggtgg  ctccggatg  cacgagact  gcctacgcc  ccatcaatg  ttcccgtgt  960
cccatcatg  agctcccaa  ttacaccgg  tccatctac  ccaccgtga  gccctacca  1020
tatcccaag  ctggaagtg  gaaccccag  atttcccta  acgttattg  cttaaatgg  1080
cccacccat  atctggaga  gatgccgcc  gatgatcca  ggatgaggg  gtactacat  1140
accatggtg  agtgggcca  cagcaccaa  gtcgccgtg  cctggctga  ccgggcgca  1200
aacgtgtcc  tcctcaccc  ctgcgacgc  accacgggg  tctgcacga  gaaacacga  1260
gatgaaagt  aggcctggc  ccacagaca  aatgaagaa  ctgtgttct  caaggatgg  1320
cgaaagttt  tcttcatca  agccatccc  cagggagga  gagggaaat  ctatcacat  1380
acggtgtcc  cgtcccagc  caacagcag  aacgacaac  tccagtcca  cacctccgg  1440
gactgggac  tgaccaaga  cctagccta  gatgagaag  ggaataaga  ctacttcct  1500
agcacggag  acctgcctc  gagacgaca  ctctacagt  ccaacacgg  gggcaactt  1560
aacaggcag  gcctctcct  tgacctggt  gagaactgc  cctacttca  cgcttcctt  1620
agccatagc  tggacttct  cctgctcaa  tgcgaaggt  ctggtgttc  tatggtgac  1680
gtgcacaac  caacagata  gaaaaaaat  tttgaccta  aaacaaatg  acatgtcaa  1740
aaggccata  atgaccgac  gatgcctaa  gtggaatac  gggacattg  gattgatga  1800
tacaacctg  ccatgcaga  actgaagcc  gcaaccttc  ccgacacca  ccactaccc  1860
ctgctcctg  tggtggatg  caccccggg  agccagagt  tagctgaga  gttcgaggt  1920
agctgggag  cggtgatgg  gagcagcca  ggcgcggtg  tggtaaagt  tgacggccg  1980
ggcagcggc  tccaaggga  caagctcct  cacgaagtg  ggcggcggc  gggcttgct  2040
gaggagaag  accagatgg  ggccgtgcg  acgatgctg  aggagcagt  cattgacag  2100
acgcgcgtg  ccgtgttcg  gaaggatta  ggtggctac  tgagcacct  catcctccc  2160
gcaaaggga  aaaatcaag  ccagacatt  acctgcggc  ctgctctct  tccaataac  2220
gacttcaaa  tctatgcct  tgcgttttc  gagaggtac  tgggcctcc  tggacttga  2280
aacagagca  acgagatga  caaggtagc  catcgagtc  ccgcgctgg  agaacagca  2340
ttcctgatc  ttcatccca  tgccgatga  aaaattcat  tccagcaca  agcagaact  2400
attacacaa  taattaggg  aaaggctaa  tacagctta  agatttacc  ggacgaaag  2460
cattacttt  ccagctcca  cctcaaaca  catctgtac  ggtccatca  caacttctt  2520
gtggaatgc  tcaggatcc  ggacaaact  ccgacagtc  cagcgaaag  ggacgagga  2580
gaggactaa  ctcaggtcg  tctaagcac  aacgtggct  tttctacaa  cagatgcaa  2640
cgagggatt  ccctgccct  cctcttccc  cggaggggc  gggcggggc  gggccgggc  2700
taccatagc  tgtgtgtct  ggatgcgga  ggcagtttt  cttgggaaa  aagctcctt  2760
ccggggtca  cactcacgg  ctccatggc  ccagggaca  cgctgtccc  gcagcagcg  2820
ctcctcccg  cgcccgaga  accggcacg  cacggcccc  cccccaagg  acagagcaa  2880
ggatggtgc  gcaggcccc  gcccacagg  caccggccc  tagattcca  ccaccaatg  2940
gaagatgag  ctcgcccac  ctagcctct  tgttaccgt  agcatcaca  cctgtctca  3000
gtcgcagtg  catggacgc  gcagttaca  caccattgt  ttagcagtg  gtgttcata  3060
atgggcttg  tacttcctg  aatgaggac  ttcaacatg  tgaggggct  caagaaaac  3120
cttttctgt  cagagtctt  ctgtagcta  gctaatggt  aacctgata  aattaactc  3180
tatttttct  tggttttaa  ctgatgctc  actgtctcc  tcaggggtt  ttttgctgt  3240
tggggttgg  ccttgtttc  cttggcttt  tccagtcca  gtgtagact  tgcgcttgt  3300
tggatgaag  agcagatcg  aagtaactg  tccctcctc  aggttgtct  cagacgtct  3360
ggagacgtt  ctaaacact  aggggggaa  acagccaat  gcacccatt  aaagaaata  3420
ctaaataaa  cctctctcc  actcagcta  gctagggct  ggctgtagg  gtgcactgt  3480
tatttacat  cgtccttac  accatcctt  tcctccttg  taccgtatt  aagctcttt  3540
ccatgacat  tggttg  3556



<210> 3905
<211> 865
<212> PRT
<213> Homo sapiens
<308> P42658
<400> 3905

Met Ala Ser Leu Tyr Gln Arg Phe Thr Gly Lys Ile Asn Thr Ser Arg 
  1               5                  10                  15
Ser Phe Pro Ala Pro Pro Glu Ala Ser His Leu Leu Gly Gly Gln Gly 
             20                  25                  30
Pro Glu Glu Asp Gly Gly Ala Gly Ala Lys Pro Leu Gly Pro Arg Ala 
         35                  40                  45
Gln Ala Ala Ala Pro Arg Glu Arg Gly Gly Gly Gly Gly Gly Ala Gly 
     50                  55                  60
Gly Arg Pro Arg Phe Gln Tyr Gln Gly Arg Ser Asp Gly Asp Glu Glu 
 65                  70                  75                  80
Asp Glu Leu Val Gly Ser Asn Pro Pro Gln Arg Asn Trp Lys Gly Ile 
                 85                  90                  95
Ala Ile Ala Leu Leu Val Ile Leu Val Ile Cys Ser Leu Ile Val Thr 
             100                105                110
Ser Val Ile Leu Leu Thr Pro Ala Glu Asp Asn Ser Leu Ser Gln Lys 
         115                120                125
Lys Lys Val Thr Val Glu Asp Leu Phe Ser Glu Asp Phe Lys Ile His 
     130                135                140
Asp Pro Glu Ala Lys Trp Ile Ser Asp Thr Glu Phe Ile Tyr Arg Glu 
 145                150                155                160
Gln Lys Gly Thr Val Arg Leu Trp Asn Val Glu Thr Asn Thr Ser Thr 
                 165                170                175
Val Leu Ile Glu Gly Lys Lys Ile Glu Ser Leu Arg Ala Ile Arg Tyr 
             180                185                190
Glu Ile Ser Pro Asp Arg Glu Tyr Ala Leu Phe Ser Tyr Asn Val Glu 
         195                200                205
Pro Ile Tyr Gln His Ser Tyr Thr Gly Tyr Tyr Val Leu Ser Lys Ile 
     210                215                220
Pro His Gly Asp Pro Gln Ser Leu Asp Pro Pro Glu Val Ser Asn Ala 
 225                230                235                240
Lys Leu Gln Tyr Ala Gly Trp Gly Pro Lys Gly Gln Gln Leu Ile Phe 
                 245                250                255
Ile Phe Glu Asn Asn Ile Tyr Tyr Cys Ala His Val Gly Lys Gln Ala 
             260                265                270
Ile Arg Val Val Ser Thr Gly Lys Glu Gly Val Ile Tyr Asn Gly Leu 
         275                280                285
Ser Asp Trp Leu Tyr Glu Glu Glu Ile Leu Lys Thr His Ile Ala His 
     290                295                300
Trp Trp Ser Pro Asp Gly Thr Arg Leu Ala Tyr Ala Ala Ile Asn Asp 
 305                310                315                320
Ser Arg Val Pro Ile Met Glu Leu Pro Thr Tyr Thr Gly Ser Ile Tyr 
                 325                330                335
Pro Thr Val Lys Pro Tyr His Tyr Pro Lys Ala Gly Ser Glu Asn Pro 
             340                345                350
Ser Ile Ser Leu His Val Ile Gly Leu Asn Gly Pro Thr His Asp Leu 
         355                360                365
Glu Met Met Pro Pro Asp Asp Pro Arg Met Arg Glu Tyr Tyr Ile Thr 
     370                375                380
Met Val Lys Trp Ala Thr Ser Thr Lys Val Ala Val Thr Trp Leu Asn 
 385                390                395                400
Arg Ala Gln Asn Val Ser Ile Leu Thr Leu Cys Asp Ala Thr Thr Gly 
                 405                410                415
Val Cys Thr Lys Lys His Glu Asp Glu Ser Glu Ala Trp Leu His Arg 
             420                425                430
Gln Asn Glu Glu Pro Val Phe Ser Lys Asp Gly Arg Lys Phe Phe Phe 
         435                440                445
Ile Arg Ala Ile Pro Gln Gly Gly Arg Gly Lys Phe Tyr His Ile Thr 
     450                455                460
Val Ser Ser Ser Gln Pro Asn Ser Ser Asn Asp Asn Ile Gln Ser Ile 
 465                470                475                480
Thr Ser Gly Asp Trp Asp Val Thr Lys Ile Leu Ala Tyr Asp Glu Lys 
                 485                490                495
Gly Asn Lys Ile Tyr Phe Leu Ser Thr Glu Asp Leu Pro Arg Arg Arg 
             500                505                510
Gln Leu Tyr Ser Ala Asn Thr Glu Gly Asn Phe Asn Arg Gln Cys Leu 
         515                520                525
Ser Cys Asp Leu Val Glu Asn Cys Thr Tyr Phe Ser Ala Ser Phe Ser 
     530                535                540
His Ser Met Asp Phe Phe Leu Leu Lys Cys Glu Gly Pro Gly Val Pro 
 545                550                555                560
Met Val Thr Val His Asn Thr Thr Asp Lys Lys Lys Met Phe Asp Leu 
                 565                570                575
Glu Thr Asn Glu His Val Lys Lys Ala Ile Asn Asp Arg Gln Met Pro 
             580                585                590
Lys Val Glu Tyr Arg Asp Ile Glu Ile Asp Asp Tyr Asn Leu Pro Met 
         595                600                605
Gln Ile Leu Lys Pro Ala Thr Phe Thr Asp Thr Thr His Tyr Pro Leu 
     610                615                620
Leu Leu Val Val Asp Gly Thr Pro Gly Ser Gln Ser Val Ala Glu Lys 
 625                630                635                640
Phe Glu Val Ser Trp Glu Thr Val Met Val Ser Ser His Gly Ala Val 
                 645                650                655
Val Val Lys Cys Asp Gly Arg Gly Ser Gly Phe Gln Gly Thr Lys Leu 
             660                665                670
Leu His Glu Val Arg Arg Arg Leu Gly Leu Leu Glu Glu Lys Asp Gln 
         675                680                685
Met Glu Ala Val Arg Thr Met Leu Lys Glu Gln Tyr Ile Asp Arg Thr 
     690                695                700
Arg Val Ala Val Phe Gly Lys Asp Tyr Gly Gly Tyr Leu Ser Thr Tyr 
 705                710                715                720
Ile Leu Pro Ala Lys Gly Glu Asn Gln Gly Gln Thr Phe Thr Cys Gly 
                 725                730                735
Ser Ala Leu Ser Pro Ile Thr Asp Phe Lys Leu Tyr Ala Ser Ala Phe 
             740                745                750
Ser Glu Arg Tyr Leu Gly Leu His Gly Leu Asp Asn Arg Ala Tyr Glu 
         755                760                765
Met Thr Lys Val Ala His Arg Val Ser Ala Leu Glu Glu Gln Gln Phe 
     770                775                780
Leu Ile Ile His Pro Thr Ala Asp Glu Lys Ile His Phe Gln His Thr 
 785                790                795                800
Ala Glu Leu Ile Thr Gln Leu Ile Arg Gly Lys Ala Asn Tyr Ser Leu 
                 805                810                815
Gln Ile Tyr Pro Asp Glu Ser His Tyr Phe Thr Ser Ser Ser Leu Lys 
             820                825                830
Gln His Leu Tyr Arg Ser Ile Ile Asn Phe Phe Val Glu Cys Phe Arg 
         835                840                845
Ile Gln Asp Lys Leu Pro Thr Val Thr Ala Lys Glu Asp Glu Glu Glu 
     850                855                860
Asp 
 865



<210> 3906
<211> 2819
<212> DNA
<213> Rattus norvegicus
<308> M76426
<400> 3906

gctcagcac  caggcgact  gactcgcga  tggcgcgga  cggcagggc  cgtcttttt  60
ctttctcca  cgcctcctt  tcccccctt  tcccttttc  gttggaggg  gtggggaga  120
gaaagagag  cagagagaa  ggaaatttt  tttttccga  gcatcctaa  cagtgagct  180
gcgcagagc  gcggcccat  gcttcgctg  accaaaggt  caccggcaa  atcaacacc  240
cgcgctcct  cccggcgcc  ccggaggcc  gtcaccttc  gggtggcca  gggccggag  300
aggacgccg  ctcgaagcc  ctcgggccg  aggcgcagg  ggtggcacc  cgggagcgc  360
gcggtgctg  tggccggcc  cggttccag  accaggcgc  gagcgactg  gacgaggag  420
acgagctgg  ggggagtaa  cctccacag  gaaactgga  aggaatcgc  attgcactg  480
ttgtcatcc  tgtcatctg  tccctgatt  tcacctcag  catcctgct  accccagcg  540
aagatacca  tctgtctca  aagaagaag  tgactgtgg  agatctttt  agtgaagac  600
tcaaaatcc  tgacccaga  gcaaagtgg  taagcgata  ggaattcat  tacagagaa  660
ggaaaggga  cgtcatact  cggaacgtt  agacaaata  ttccacggt  ttaatagaa  720
gcaaaaaaa  tgaatcgtt  agagccatc  gatatgaaa  atccccaga  aaagagtat  780
cgttgtttt  ctataatgt  gaaccggta  accaacact  ccacactgg  tattatgtt  840
tgagcaaaa  tcctcacgg  gaccctcag  gtctggacc  accagaagt  agcaacgcg  900
agcttcagt  tgcagggtg  ggcccgaaa  gccagcagc  gatatttat  tttgagaac  960
acatctact  ctgtgccca  gttggaaag  aggcgattc  agtggtctc  acggggaag  1020
agggtgtga  ctacaatgg  ctcagcgac  ggctgtatg  agaggagat  ctgaagagc  1080
acatcgcac  ttggtggtc  ccagatggt  caaggctcg  ctatgccac  atcaatgat  1140
cccgagttc  acttatgga  ctgccaacc  acacgggct  tgtctaccc  actgtgaag  1200
cctaccact  tcctaaggc  ggcagtgaa  accccagca  ctccctcca  gtcatcggc  1260
tgaatggac  cacccacga  ctggagatg  tgccacctg  cgacccccg  atgagagag  1320
attacatca  catggtgaa  tgggccacc  gcaccaagg  tgctgtgac  tggctgaac  1380
gggcccaga  tgtgtccat  ctgaccctc  gtgatgcca  cacaggtgt  tgcactaag  1440
aacacgagg  tgaaagtga  gcttggctc  acagacaga  tgaagagcc  gtgttctcc  1500
aggatggcc  gaagttttt  tttgtcaga  cgatcccac  gggaggccg  ggtaaattc  1560
accacatca  tgtatcctc  tcccagccc  acagcagca  tgacaacat  cagtccatt  1620
cctctgggg  ctgggatgt  accgagatc  tgacctacg  tgagaagcg  aataagctc  1680
atttcctaa  cacagagga  ctgccacga  gacgacacc  ctacagcgc  aacacggta  1740
acgacttca  caggcagtg  ctgtcatgt  acctggtgg  gaactgcac  tatgtcagt  1800
cttccttca  tcataacat  gacttcttc  tgctcaagt  tgaaggccc  ggcgtaccc  1860
ctgttactg  gcacaatac  acggataag  gaagaatgt  tgacttgga  gcaaatgag  1920
aagtgcaga  agccatcta  gatcggcag  tgcctaaaa  tgaataccg  aaaattgaa  1980
tggaagatt  cagcttgcc  atgcaaatc  tgaagccgg  caccttcac  gacacagcc  2040
actaccctt  attgctcgt  gtggatggt  ctccaggga  tcagagcgt  tcagagagg  2100
ttgaagtga  ctgggagac  gtgttggtg  gcagccatg  agcagtggt  gtcaagtgt  2160
acggccgag  cagcggctt  cagggaacc  agctcttgc  cgaagtacg  aggcggcta  2220
gcttcctgg  ggagaagga  cagatggaa  ctgtgagaa  catgctgaa  gagcagtac  2280
ttgacaaga  tcgggtagc  gtgtttggg  aggattatg  tgggtacct  agtacttac  2340
tcctcccag  caagggaga  aaccaaggc  agactttca  ctgcggctc  gcactctct  2400
cgataacgg  cttcaaact  tatgcctca  cattttccg  gaggtacct  ggcctccat  2460
gactcgaca  cagagcgta  gagatgacc  agctggcac  cagagtgtc  gcactggag  2520
accagcagt  cctgatcat  catgctacg  ctgacgaaa  aatccattt  cagcacaca  2580
cagagctca  cacgcagct  atcaaggga  aggccaatt  cagcttaca  atataccca  2640
atgaaagtc  ctactttca  agcgtggcg  tcaaacagc  cctgtacag  tccatcatc  2700
gattctttg  ggaatgttt  aggatccag  acaagctac  tacagccac  gcgaaagag  2760
acgaggagg  ggactaacc  cgcttgaga  ctaaacaca  acatggctc  ttctacaac  2819



<210> 3907
<211> 859
<212> PRT
<213> Rattus norvegicus
<308> P46101
<400> 3907

Met Ala Ser Leu Tyr Gln Arg Phe Thr Gly Lys Ile Asn Thr Ser Arg 
  1               5                  10                  15
Ser Phe Pro Ala Pro Pro Glu Ala Ser His Leu Leu Gly Gly Gln Gly 
             20                  25                  30
Pro Glu Glu Asp Ala Gly Ser Lys Pro Leu Gly Pro Gln Ala Gln Ala 
         35                  40                  45
Val Ala Pro Arg Glu Arg Gly Gly Ala Gly Gly Arg Pro Arg Phe Gln 
     50                  55                  60
Tyr Gln Ala Arg Ser Asp Cys Asp Glu Glu Asp Glu Leu Val Gly Ser 
 65                  70                  75                  80
Asn Pro Pro Gln Arg Asn Trp Lys Gly Ile Ala Ile Ala Leu Leu Val 
                 85                  90                  95
Ile Leu Val Ile Cys Ser Leu Ile Val Thr Ser Val Ile Leu Leu Thr 
             100                105                110
Pro Ala Glu Asp Thr Ser Leu Ser Gln Lys Lys Lys Val Thr Val Glu 
         115                120                125
Asp Leu Phe Ser Glu Asp Phe Lys Ile His Asp Pro Glu Ala Lys Trp 
     130                135                140
Ile Ser Asp Lys Glu Phe Ile Tyr Arg Glu Arg Lys Gly Ser Val Ile 
 145                150                155                160
Leu Arg Asn Val Glu Thr Asn Asn Ser Thr Val Leu Ile Glu Gly Lys 
                 165                170                175
Lys Ile Glu Ser Leu Arg Ala Ile Arg Tyr Glu Ile Ser Pro Asp Lys 
             180                185                190
Glu Tyr Ala Leu Phe Ser Tyr Asn Val Glu Pro Val Tyr Gln His Ser 
         195                200                205
His Thr Gly Tyr Tyr Val Leu Ser Lys Ile Pro His Gly Asp Pro Gln 
     210                215                220
Ser Leu Asp Pro Pro Glu Val Ser Asn Ala Lys Leu Gln Tyr Ala Gly 
 225                230                235                240
Trp Gly Pro Lys Gly Gln Gln Leu Ile Phe Ile Phe Glu Asn Asn Ile 
                 245                250                255
Tyr Tyr Cys Ala His Val Gly Lys Gln Ala Ile Arg Val Val Ser Thr 
             260                265                270
Gly Lys Glu Gly Val Ile Tyr Asn Gly Leu Ser Asp Trp Leu Tyr Glu 
         275                280                285
Glu Glu Ile Leu Lys Ser His Ile Ala His Trp Trp Ser Pro Asp Gly 
     290                295                300
Thr Arg Leu Ala Tyr Ala Thr Ile Asn Asp Ser Arg Val Pro Leu Met 
 305                310                315                320
Glu Leu Pro Thr Tyr Thr Gly Ser Val Tyr Pro Thr Val Lys Pro Tyr 
                 325                330                335
His Tyr Pro Lys Ala Gly Ser Glu Asn Pro Ser Ile Ser Leu His Val 
             340                345                350
Ile Gly Leu Asn Gly Pro Thr His Asp Leu Glu Met Met Pro Pro Asp 
         355                360                365
Asp Pro Arg Met Arg Glu Tyr Tyr Ile Thr Met Val Lys Trp Ala Thr 
     370                375                380
Ser Thr Lys Val Ala Val Thr Trp Leu Asn Arg Ala Gln Asn Val Ser 
 385                390                395                400
Ile Leu Thr Leu Cys Asp Ala Thr Thr Gly Val Cys Thr Lys Lys His 
                 405                410                415
Glu Asp Glu Ser Glu Ala Trp Leu His Arg Gln Asn Glu Glu Pro Val 
             420                425                430
Phe Ser Lys Asp Gly Arg Lys Phe Phe Phe Val Arg Ala Ile Pro Gln 
         435                440                445
Gly Gly Arg Gly Lys Phe Tyr His Ile Thr Val Ser Ser Ser Gln Pro 
     450                455                460
Asn Ser Ser Asn Asp Asn Ile Gln Ser Ile Thr Ser Gly Asp Trp Asp 
 465                470                475                480
Val Thr Glu Ile Leu Thr Tyr Asp Glu Lys Arg Asn Lys Leu Tyr Phe 
                 485                490                495
Leu Ser Thr Glu Asp Leu Pro Arg Arg Arg His Leu Tyr Ser Ala Asn 
             500                505                510
Thr Val Asp Asp Phe Asn Arg Gln Cys Leu Ser Cys Asp Leu Val Glu 
         515                520                525
Asn Cys Thr Tyr Val Ser Ala Ser Phe Ser His Asn Met Asp Phe Phe 
     530                535                540
Leu Leu Lys Cys Glu Gly Pro Gly Val Pro Thr Val Thr Val His Asn 
 545                550                555                560
Thr Thr Asp Lys Arg Arg Met Phe Asp Leu Glu Ala Asn Glu Gln Val 
                 565                570                575
Gln Lys Ala Ile Tyr Asp Arg Gln Met Pro Lys Ile Glu Tyr Arg Lys 
             580                585                590
Ile Glu Val Glu Asp Tyr Ser Leu Pro Met Gln Ile Leu Lys Pro Ala 
         595                600                605
Thr Phe Thr Asp Thr Ala His Tyr Pro Leu Leu Leu Val Val Asp Gly 
     610                615                620
Thr Pro Gly Ser Gln Ser Val Ser Glu Arg Phe Glu Val Thr Trp Glu 
 625                630                635                640
Thr Val Leu Val Ser Ser His Gly Ala Val Val Val Lys Cys Asp Gly 
                 645                650                655
Arg Gly Ser Gly Phe Gln Gly Thr Lys Leu Leu His Glu Val Arg Arg 
             660                665                670
Arg Leu Gly Phe Leu Glu Glu Lys Asp Gln Met Glu Ala Val Arg Thr 
         675                680                685
Met Leu Lys Glu Gln Tyr Ile Asp Lys Thr Arg Val Ala Val Phe Gly 
     690                695                700
Lys Asp Tyr Gly Gly Tyr Leu Ser Thr Tyr Ile Leu Pro Ala Lys Gly 
 705                710                715                720
Glu Asn Gln Gly Gln Thr Phe Thr Cys Gly Ser Ala Leu Ser Pro Ile 
                 725                730                735
Thr Asp Phe Lys Leu Tyr Ala Ser Ala Phe Ser Glu Arg Tyr Leu Gly 
             740                745                750
Leu His Gly Leu Asp Asn Arg Ala Tyr Glu Met Thr Lys Leu Ala His 
         755                760                765
Arg Val Ser Ala Leu Glu Asp Gln Gln Phe Leu Ile Ile His Ala Thr 
     770                775                780
Ala Asp Glu Lys Ile His Phe Gln His Thr Ala Glu Leu Ile Thr Gln 
 785                790                795                800
Leu Ile Lys Gly Lys Ala Asn Tyr Ser Leu Gln Ile Tyr Pro Asp Glu 
                 805                810                815
Ser His Tyr Phe His Ser Val Ala Leu Lys Gln His Leu Tyr Arg Ser 
             820                825                830
Ile Ile Gly Phe Phe Val Glu Cys Phe Arg Ile Gln Asp Lys Leu Pro 
         835                840                845
Thr Ala Thr Ala Lys Glu Asp Glu Glu Glu Asp 
     850                855



<210> 3908
<211> 3556
<212> DNA
<213> Homo sapiens
<308> M96860
<400> 3908

agcaaactc  tcttgtcta  ccaccctcc  tcccccatc  tccccaaaa  agccttgtg  60
tttcggaag  atggactaa  atcacactc  tccttacct  accgcttgg  ctctggtgg  120
tcccaactc  ccgtcagac  ccacctgcc  cggtggtgg  aagcgcctg  acagaccat  180
accacagcc  aggagccaa  cgcttcggg  aaatccgtg  agcagcagg  acaggagct  240
gtggggagt  accctccgc  gaggaattg  aaaggaata  caattgcac  gcttgtcat  300
ctggtcatc  gctccttga  cgtcacctc  gtcatactt  tgacaccag  ggaagataa  360
agtctgtct  aaaagaaga  ggtcactgt  gaagatctc  tcagtgaag  cttcaaaat  420
catgacccc  aggctaagt  gataagtga  acagaattc  tctacagag  acagaaagg  480
acagtgaga  tgtggaatg  tgaaacaaa  acttctact  tcttaatag  aggcaaaaa  540
attgaatca  taagagcca  cagatatga  atatctcca  atagagagt  tgcactttt  600
tcatacaat  tggaaccca  atatcaaca  tcgtatact  gatattatg  cctgagcaa  660
attcctcat  gggatcctc  aagtctgga  ccaccagaa  tcagcaatg  aaagcttca  720
tatgcagga  ggggcccta  aggccaaca  ctgatattt  tttttgaaa  caatatcta  780
tactgtgca  atgtcggga  acaggccat  cgtgtggtc  ccactggca  ggaaggtgt  840
atttacaat  gcctcagtg  ctggctgta  gaagaggag  ttttgaaga  acacatcgc  900
cactggtgg  ctccggatg  cacgagact  gcctacgcc  ccatcaatg  ttcccgtgt  960
cccatcatg  agctcccaa  ttacaccgg  tccatctac  ccaccgtga  gccctacca  1020
tatcccaag  ctggaagtg  gaaccccag  atttcccta  acgttattg  cttaaatgg  1080
cccacccat  atctggaga  gatgccgcc  gatgatcca  ggatgaggg  gtactacat  1140
accatggtg  agtgggcca  cagcaccaa  gtcgccgtg  cctggctga  ccgggcgca  1200
aacgtgtcc  tcctcaccc  ctgcgacgc  accacgggg  tctgcacga  gaaacacga  1260
gatgaaagt  aggcctggc  ccacagaca  aatgaagaa  ctgtgttct  caaggatgg  1320
cgaaagttt  tcttcatca  agccatccc  cagggagga  gagggaaat  ctatcacat  1380
acggtgtcc  cgtcccagc  caacagcag  aacgacaac  tccagtcca  cacctccgg  1440
gactgggac  tgaccaaga  cctagccta  gatgagaag  ggaataaga  ctacttcct  1500
agcacggag  acctgcctc  gagacgaca  ctctacagt  ccaacacgg  gggcaactt  1560
aacaggcag  gcctctcct  tgacctggt  gagaactgc  cctacttca  cgcttcctt  1620
agccatagc  tggacttct  cctgctcaa  tgcgaaggt  ctggtgttc  tatggtgac  1680
gtgcacaac  caacagata  gaaaaaaat  tttgaccta  aaacaaatg  acatgtcaa  1740
aaggccata  atgaccgac  gatgcctaa  gtggaatac  gggacattg  gattgatga  1800
tacaacctg  ccatgcaga  actgaagcc  gcaaccttc  ccgacacca  ccactaccc  1860
ctgctcctg  tggtggatg  caccccggg  agccagagt  tagctgaga  gttcgaggt  1920
agctgggag  cggtgatgg  gagcagcca  ggcgcggtg  tggtaaagt  tgacggccg  1980
ggcagcggc  tccaaggga  caagctcct  cacgaagtg  ggcggcggc  gggcttgct  2040
gaggagaag  accagatgg  ggccgtgcg  acgatgctg  aggagcagt  cattgacag  2100
acgcgcgtg  ccgtgttcg  gaaggatta  ggtggctac  tgagcacct  catcctccc  2160
gcaaaggga  aaaatcaag  ccagacatt  acctgcggc  ctgctctct  tccaataac  2220
gacttcaaa  tctatgcct  tgcgttttc  gagaggtac  tgggcctcc  tggacttga  2280
aacagagca  acgagatga  caaggtagc  catcgagtc  ccgcgctgg  agaacagca  2340
ttcctgatc  ttcatccca  tgccgatga  aaaattcat  tccagcaca  agcagaact  2400
attacacaa  taattaggg  aaaggctaa  tacagctta  agatttacc  ggacgaaag  2460
cattacttt  ccagctcca  cctcaaaca  catctgtac  ggtccatca  caacttctt  2520
gtggaatgc  tcaggatcc  ggacaaact  ccgacagtc  cagcgaaag  ggacgagga  2580
gaggactaa  ctcaggtcg  tctaagcac  aacgtggct  tttctacaa  cagatgcaa  2640
cgagggatt  ccctgccct  cctcttccc  cggaggggc  gggcggggc  gggccgggc  2700
taccatagc  tgtgtgtct  ggatgcgga  ggcagtttt  cttgggaaa  aagctcctt  2760
ccggggtca  cactcacgg  ctccatggc  ccagggaca  cgctgtccc  gcagcagcg  2820
ctcctcccg  cgcccgaga  accggcacg  cacggcccc  cccccaagg  acagagcaa  2880
ggatggtgc  gcaggcccc  gcccacagg  caccggccc  tagattcca  ccaccaatg  2940
gaagatgag  ctcgcccac  ctagcctct  tgttaccgt  agcatcaca  cctgtctca  3000
gtcgcagtg  catggacgc  gcagttaca  caccattgt  ttagcagtg  gtgttcata  3060
atgggcttg  tacttcctg  aatgaggac  ttcaacatg  tgaggggct  caagaaaac  3120
cttttctgt  cagagtctt  ctgtagcta  gctaatggt  aacctgata  aattaactc  3180
tatttttct  tggttttaa  ctgatgctc  actgtctcc  tcaggggtt  ttttgctgt  3240
tggggttgg  ccttgtttc  cttggcttt  tccagtcca  gtgtagact  tgcgcttgt  3300
tggatgaag  agcagatcg  aagtaactg  tccctcctc  aggttgtct  cagacgtct  3360
ggagacgtt  ctaaacact  aggggggaa  acagccaat  gcacccatt  aaagaaata  3420
ctaaataaa  cctctctcc  actcagcta  gctagggct  ggctgtagg  gtgcactgt  3480
tatttacat  cgtccttac  accatcctt  tcctccttg  taccgtatt  aagctcttt  3540
ccatgacat  tggttg  3556



<210> 3909
<211> 865
<212> PRT
<213> Homo sapiens
<308> P42658
<400> 3909

Met Ala Ser Leu Tyr Gln Arg Phe Thr Gly Lys Ile Asn Thr Ser Arg 
  1               5                  10                  15
Ser Phe Pro Ala Pro Pro Glu Ala Ser His Leu Leu Gly Gly Gln Gly 
             20                  25                  30
Pro Glu Glu Asp Gly Gly Ala Gly Ala Lys Pro Leu Gly Pro Arg Ala 
         35                  40                  45
Gln Ala Ala Ala Pro Arg Glu Arg Gly Gly Gly Gly Gly Gly Ala Gly 
     50                  55                  60
Gly Arg Pro Arg Phe Gln Tyr Gln Gly Arg Ser Asp Gly Asp Glu Glu 
 65                  70                  75                  80
Asp Glu Leu Val Gly Ser Asn Pro Pro Gln Arg Asn Trp Lys Gly Ile 
                 85                  90                  95
Ala Ile Ala Leu Leu Val Ile Leu Val Ile Cys Ser Leu Ile Val Thr 
             100                105                110
Ser Val Ile Leu Leu Thr Pro Ala Glu Asp Asn Ser Leu Ser Gln Lys 
         115                120                125
Lys Lys Val Thr Val Glu Asp Leu Phe Ser Glu Asp Phe Lys Ile His 
     130                135                140
Asp Pro Glu Ala Lys Trp Ile Ser Asp Thr Glu Phe Ile Tyr Arg Glu 
 145                150                155                160
Gln Lys Gly Thr Val Arg Leu Trp Asn Val Glu Thr Asn Thr Ser Thr 
                 165                170                175
Val Leu Ile Glu Gly Lys Lys Ile Glu Ser Leu Arg Ala Ile Arg Tyr 
             180                185                190
Glu Ile Ser Pro Asp Arg Glu Tyr Ala Leu Phe Ser Tyr Asn Val Glu 
         195                200                205
Pro Ile Tyr Gln His Ser Tyr Thr Gly Tyr Tyr Val Leu Ser Lys Ile 
     210                215                220
Pro His Gly Asp Pro Gln Ser Leu Asp Pro Pro Glu Val Ser Asn Ala 
 225                230                235                240
Lys Leu Gln Tyr Ala Gly Trp Gly Pro Lys Gly Gln Gln Leu Ile Phe 
                 245                250                255
Ile Phe Glu Asn Asn Ile Tyr Tyr Cys Ala His Val Gly Lys Gln Ala 
             260                265                270
Ile Arg Val Val Ser Thr Gly Lys Glu Gly Val Ile Tyr Asn Gly Leu 
         275                280                285
Ser Asp Trp Leu Tyr Glu Glu Glu Ile Leu Lys Thr His Ile Ala His 
     290                295                300
Trp Trp Ser Pro Asp Gly Thr Arg Leu Ala Tyr Ala Ala Ile Asn Asp 
 305                310                315                320
Ser Arg Val Pro Ile Met Glu Leu Pro Thr Tyr Thr Gly Ser Ile Tyr 
                 325                330                335
Pro Thr Val Lys Pro Tyr His Tyr Pro Lys Ala Gly Ser Glu Asn Pro 
             340                345                350
Ser Ile Ser Leu His Val Ile Gly Leu Asn Gly Pro Thr His Asp Leu 
         355                360                365
Glu Met Met Pro Pro Asp Asp Pro Arg Met Arg Glu Tyr Tyr Ile Thr 
     370                375                380
Met Val Lys Trp Ala Thr Ser Thr Lys Val Ala Val Thr Trp Leu Asn 
 385                390                395                400
Arg Ala Gln Asn Val Ser Ile Leu Thr Leu Cys Asp Ala Thr Thr Gly 
                 405                410                415
Val Cys Thr Lys Lys His Glu Asp Glu Ser Glu Ala Trp Leu His Arg 
             420                425                430
Gln Asn Glu Glu Pro Val Phe Ser Lys Asp Gly Arg Lys Phe Phe Phe 
         435                440                445
Ile Arg Ala Ile Pro Gln Gly Gly Arg Gly Lys Phe Tyr His Ile Thr 
     450                455                460
Val Ser Ser Ser Gln Pro Asn Ser Ser Asn Asp Asn Ile Gln Ser Ile 
 465                470                475                480
Thr Ser Gly Asp Trp Asp Val Thr Lys Ile Leu Ala Tyr Asp Glu Lys 
                 485                490                495
Gly Asn Lys Ile Tyr Phe Leu Ser Thr Glu Asp Leu Pro Arg Arg Arg 
             500                505                510
Gln Leu Tyr Ser Ala Asn Thr Glu Gly Asn Phe Asn Arg Gln Cys Leu 
         515                520                525
Ser Cys Asp Leu Val Glu Asn Cys Thr Tyr Phe Ser Ala Ser Phe Ser 
     530                535                540
His Ser Met Asp Phe Phe Leu Leu Lys Cys Glu Gly Pro Gly Val Pro 
 545                550                555                560
Met Val Thr Val His Asn Thr Thr Asp Lys Lys Lys Met Phe Asp Leu 
                 565                570                575
Glu Thr Asn Glu His Val Lys Lys Ala Ile Asn Asp Arg Gln Met Pro 
             580                585                590
Lys Val Glu Tyr Arg Asp Ile Glu Ile Asp Asp Tyr Asn Leu Pro Met 
         595                600                605
Gln Ile Leu Lys Pro Ala Thr Phe Thr Asp Thr Thr His Tyr Pro Leu 
     610                615                620
Leu Leu Val Val Asp Gly Thr Pro Gly Ser Gln Ser Val Ala Glu Lys 
 625                630                635                640
Phe Glu Val Ser Trp Glu Thr Val Met Val Ser Ser His Gly Ala Val 
                 645                650                655
Val Val Lys Cys Asp Gly Arg Gly Ser Gly Phe Gln Gly Thr Lys Leu 
             660                665                670
Leu His Glu Val Arg Arg Arg Leu Gly Leu Leu Glu Glu Lys Asp Gln 
         675                680                685
Met Glu Ala Val Arg Thr Met Leu Lys Glu Gln Tyr Ile Asp Arg Thr 
     690                695                700
Arg Val Ala Val Phe Gly Lys Asp Tyr Gly Gly Tyr Leu Ser Thr Tyr 
 705                710                715                720
Ile Leu Pro Ala Lys Gly Glu Asn Gln Gly Gln Thr Phe Thr Cys Gly 
                 725                730                735
Ser Ala Leu Ser Pro Ile Thr Asp Phe Lys Leu Tyr Ala Ser Ala Phe 
             740                745                750
Ser Glu Arg Tyr Leu Gly Leu His Gly Leu Asp Asn Arg Ala Tyr Glu 
         755                760                765
Met Thr Lys Val Ala His Arg Val Ser Ala Leu Glu Glu Gln Gln Phe 
     770                775                780
Leu Ile Ile His Pro Thr Ala Asp Glu Lys Ile His Phe Gln His Thr 
 785                790                795                800
Ala Glu Leu Ile Thr Gln Leu Ile Arg Gly Lys Ala Asn Tyr Ser Leu 
                 805                810                815
Gln Ile Tyr Pro Asp Glu Ser His Tyr Phe Thr Ser Ser Ser Leu Lys 
             820                825                830
Gln His Leu Tyr Arg Ser Ile Ile Asn Phe Phe Val Glu Cys Phe Arg 
         835                840                845
Ile Gln Asp Lys Leu Pro Thr Val Thr Ala Lys Glu Asp Glu Glu Glu 
     850                855                860
Asp 
 865



<210> 3910
<211> 1341
<212> DNA
<213> Rattus norvegicus
<308> M76740
<400> 3910

ggcaccacc  ctgttgatt  cacgaccac  gctgagttc  ccaccactc  tgatgtcac  60
accactcct  atgtgacca  cacccctgg  gtcaccacc  ctgctggtg  caccaccac  120
cctgatgtc  ccaccactg  tggtgtcac  accactcct  acgtcacca  cactgctga  180
gtcaccacc  ctcctgatg  gaccaccac  gctgatgtc  ccaccactg  tggtatcac  240
accactcct  atgtgacca  cactgctgg  gtcaccacc  ctcctgatg  caccaccac  300
cctgatgtc  ccaccactc  tgatgtcac  accactcct  atgtcacca  cactcctga  360
gtcaccacc  ctcctgata  aaccaccac  cctgataca  ccaccactc  tcaggtcac  420
accactgtt  atgtcacga  cactgttga  gtcaccacc  ctgctgagg  caccaccac  480
actgaggtc  ccacctctc  tgatgcaac  accactact  acgtcacca  cactcctga  540
gcaaccacc  ctgatggtg  caccaccac  cctgatgtc  ccaccactt  tgatgtgac  600
accactgct  atgtcacca  cactgctag  gtcaccacc  ctcctgatg  caccaccac  660
cctgatgtc  ccaccactc  tgatgtgac  accactgct  gtgtcacca  cactcctga  720
gccaccacc  ctcctgatg  aaccaccac  cctcaggtc  ccaccactg  tgatgtcac  780
accactgct  gtgtcacca  cactgctgg  gtcaccacc  ctccagatg  caccacgac  840
cctgatgtg  ccaccactc  tgacgtcac  accactgct  gtgtcacca  cactgctga  900
gtcaccacc  ctcctgaag  caccaccac  cctgaggtc  ccaccactc  tgctgtcac  960
accacgcct  gtgtcacta  cactcctgc  gtcactacg  cacgtgtca  caccaccat  1020
cctgtcatc  ctactacgc  tgtcatgac  accactcca  tgaattgcc  gaacggagg  1080
tactggtca  gtgcgatgt  cgtctgccc  aatggcttc  caggggatc  ctgtcagaa  1140
agagtccct  tggtcgact  ccagaacgg  ggcacgtgg  atgggctca  atgtcagtg  1200
accggcctc  tctatggcc  aaggtgtga  gaagtgatg  agagcgtag  gataaagcc  1260
acggtctct  catctgtgg  agtgagtgt  acagtaacc  gtcaagaat  tagtaatga  1320
ctacaggac  gaaactcca  a  1341



<210> 3911
<211> 447
<212> PRT
<213> Rattus norvegicus
<308> AAA41642
<400> 3911

Gly Thr Thr Thr Val Asp Phe Thr Thr Thr Ala Glu Phe Thr Thr Thr 
  1               5                  10                  15
Pro Asp Val Thr Thr Thr Pro Asp Val Thr Thr Thr Pro Gly Val Thr 
             20                  25                  30
Thr Thr Ala Gly Val Thr Thr Thr Pro Asp Val Thr Thr Thr Ala Gly 
         35                  40                  45
Val Thr Thr Thr Pro Asp Val Thr Thr Thr Ala Asp Val Thr Thr Thr 
     50                  55                  60
Pro Asp Val Thr Thr Thr Ala Asp Val Thr Thr Thr Ala Gly Ile Thr 
 65                  70                  75                  80
Thr Thr Pro Asp Val Thr Thr Thr Ala Gly Val Thr Thr Thr Pro Asp 
                 85                  90                  95
Val Thr Thr Thr Pro Asp Val Thr Thr Thr Pro Asp Val Thr Thr Thr 
             100                105                110
Pro Asp Val Thr Thr Thr Pro Asp Val Thr Thr Thr Pro Asp Thr Thr 
         115                120                125
Thr Thr Pro Asp Thr Thr Thr Thr Pro Gln Val Thr Thr Thr Val Asp 
     130                135                140
Val Thr Thr Thr Val Asp Val Thr Thr Thr Ala Glu Val Thr Thr Thr 
 145                150                155                160
Thr Glu Val Thr Thr Ser Pro Asp Ala Thr Thr Thr Thr Asp Val Thr 
                 165                170                175
Thr Thr Pro Glu Ala Thr Thr Thr Asp Gly Val Thr Thr Thr Pro Asp 
             180                185                190
Val Thr Thr Thr Ser Asp Val Thr Thr Thr Ala Asp Val Thr Thr Thr 
         195                200                205
Ala Ser Val Thr Thr Thr Pro Asp Val Thr Thr Thr Pro Asp Val Thr 
     210                215                220
Thr Thr Pro Asp Val Thr Thr Thr Ala Gly Val Thr Thr Thr Pro Asp 
 225                230                235                240
Ala Thr Thr Thr Pro Asp Ala Thr Thr Thr Pro Gln Val Thr Thr Thr 
                 245                250                255
Ala Asp Val Thr Thr Thr Ala Gly Val Thr Thr Thr Ala Gly Val Thr 
             260                265                270
Thr Thr Pro Asp Val Thr Thr Thr Pro Asp Val Thr Thr Thr Pro Asp 
         275                280                285
Val Thr Thr Thr Ala Ser Val Thr Thr Thr Ala Asp Val Thr Thr Thr 
     290                295                300
Pro Glu Val Thr Thr Thr Pro Glu Val Thr Thr Thr Pro Ala Val Thr 
 305                310                315                320
Thr Thr Pro Arg Val Thr Thr Thr Pro Ala Val Thr Thr Thr Arg Val 
                 325                330                335
Ile Thr Thr Met Pro Val Ile Thr Thr Thr Pro Val Met Thr Thr Thr 
             340                345                350
Pro Val Asn Cys Leu Asn Gly Gly Tyr Trp Ser Gly Ala Met Cys Val 
         355                360                365
Cys Pro Asn Gly Phe Ser Gly Asp Arg Cys Gln Asn Arg Val Pro Val 
     370                375                380
Val Asp Cys Gln Asn Gly Gly Thr Trp Asp Gly Leu Lys Cys Gln Cys 
 385                390                395                400
Thr Gly Leu Phe Tyr Gly Pro Arg Cys Glu Glu Val Met Glu Ser Val 
                 405                410                415
Glu Ile Lys Pro Thr Val Ser Ala Ser Val Glu Val Ser Val Thr Val 
             420                425                430
Thr Ser Gln Glu Tyr Ser Asn Glu Leu Gln Asp Arg Asn Ser Thr 
         435                440                445



<210> 3912
<211> 4707
<212> DNA
<213> Homo sapiens
<308> AF007194
<400> 3912

gatcaccat  accgagacc  cctcacaca  tactcccag  tacactacc  caatcacca  60
caccgagac  ccctcacac  gtactccca  ctacactac  tcaatcacc  ccaccgaga  120
cccatcaca  agtactccc  gcttcactt  ttcaatcac  accaccgag  ccacatccc  180
cagtactcc  agcttcact  cttcaatca  gaccaccga  accacatcc  acagtactc  240
cagcttcac  tcttcaaat  ccatcactg  gaccacctc  cacagtact  ccagctaca  300
tacctcaat  accaccacc  agaccccct  aagcagtac  cccagcttc  gttcttcga  360
caccaccac  gagaccaca  cccacagta  tcccggctt  acttcttca  tcaccacca  420
tgagactac  tcccacagt  ctcccagct  cacttcttc  atcaccacc  ctgagacca  480
ctcacatga  actcccagc  tcacttctt  aatcaccac  agtgagacc  cctcacaca  540
tactcccag  tccacttct  taatcacca  caccaagac  acctcacac  gtactccca  600
cttcacttc  tcgatcacc  ccaccgaga  cacctcaca  agtgctcgc  gcttcactt  660
ttcgatcac  accaccgag  ccacctcac  caatactcg  agcttcact  cttcgatca  720
caccaccga  accaactct  acagtacta  cagcttcac  tcttcgatc  ccaccaccg  780
gaccacctc  cacagtact  ccagcttca  ttcttcaat  accaccact  agaccccct  840
acacagtac  cctggccta  cttcgtggg  caccaccac  aagaccacc  cacacatta  900
tcctggcct  acttcttca  tcaccacca  tgagactac  tcacacagt  ctcccggct  960
cacttcttc  atcaccacc  ctgagacca  ctcagagag  actcccagc  tcagttctt  1020
aaccatcta  tccacagtc  gcacatcca  aactgccat  acctcacat  ttactacct  1080
agagactgc  gtgactccc  cacctgtaa  cccatcttc  ctgagtaca  acatcccga  1140
cacaagcct  cgaactctc  ccccttcgt  tgtgggcac  agcacttca  tgactacaa  1200
cacagactt  ccctctata  ccactgata  cagtacctt  ccaactcga  cacacatca  1260
ttcatcttc  ccctccatc  aaagtacag  aacctcatc  cttgtgggc  ccacctctc  1320
caccatgtc  actgtgaga  tgaccctca  aattactga  aacacccca  tcagttcct  1380
tagcacaag  attgttgtt  tacctgaaa  cccaacaca  acccctcct  tactgacgt  1440
agccactgg  acccaaaca  ctcctgcac  tactactgt  acctttgga  gtacggatt  1500
ctccacgtc  actcttcat  ctcttactc  atcaacagc  ttgagcacg  tcgtgtcaa  1560
atcacaggt  cctattcct  gcacacatt  ctccaccct  caaacaact  cttctactc  1620
ctcattgca  acttcactc  catctacaa  tgagttcac  acagaatct  tcactaggg  1680
aagtacgtc  acaaatgca  tcttgactt  ttttagtac  atcatctgg  cctcaacac  1740
cactattat  atgtcctct  ctccatctt  tgccagcat  actccagtg  tctccacta  1800
cattcattc  gttccttct  caccataca  tttcagtac  gaaaatgtg  gctccgctt  1860
tatcacagg  tttcctagt  tctcttcct  tgcaactac  agcacttct  caaccagct  1920
ctctctgac  acagctctc  ctgaaataa  ccccttttc  tatatttcc  ttccctcca  1980
cacaccctg  ccaggaact  taacaatta  catagtccc  gcctctccc  ctgatccat  2040
tgttgaaat  gatcccagc  ctgaagcta  ttctcctcc  accacccca  taacagtct  2100
tccctttac  accgaaatg  tcacctgtc  tacctccat  agtatccaa  ctactctta  2160
tacatatat  gacacttct  ccatgatgc  agaaagtga  tccagcatc  cacccaatg  2220
ttccagttc  actggcact  ggactgtac  cacaaacac  gttttcaca  gtactcgac  2280
gcccaccag  gagacctgg  tgagcaaca  ttctgtgat  cccctacct  ttcctggcg  2340
ctctaccat  ccgctcacc  tgaaaccaa  cagtagcct  ccgaccatc  tgaggactt  2400
aagcaagtc  acacaccca  ccccaccca  cactaggac  tcagagaca  cagtggcca  2460
tacccagac  cctaccacc  ttacatcac  caggacaac  cgcatcact  ctcagatga  2520
cacacagtc  acgttgacc  ccactgcag  cacctgtga  aatggtggc  cctgggaac  2580
gggccagtg  gcttgcctt  cggggtttt  tggggaccg  tgtcagctc  agaccagat  2640
ccagaatgg  ggtcagtgg  atggcctca  atgccagtg  cccagcacc  tctatggtt  2700
cagttgtga  tttgctgtg  aacaggtgg  tctagatgc  gaagatttt  gcagacatg  2760
agggcttca  cttcaaggg  gtggagatc  tgtccctga  gaatggcag  atcgtggtg  2820
actacctgg  cctgctgga  atgcccttc  gcccccagc  ggagagcga  tatgagcag  2880
tgaagacca  gctgaagga  gggctgcag  acgccagcc  ggatgtgaa  agctgccag  2940
actcccaga  cctgtgttt  aagcctgac  ccatcaagg  gaacaacaa  agcaagaca  3000
agctgaccc  ggcagccat  tgccgcgcg  cgctcccac  ggctatgaa  agttctact  3060
ccccttggt  gaggccacc  ggctccgct  tgtcaccaa  tgcacgtct  gggtggaca  3120
cgccatcga  tgtcaccag  gccagtgcg  tctggagac  agcggtccc  cgtgtcgct  3180
ctactccac  gacacgcac  ggttctctg  cccgcgctg  gaggtggcc  tccactgga  3240
ggcgctggt  ggggcctga  ggccggcgc  cgctgctgg  gctgctgct  gtggcgctg  3300
gcgtccggg  ggtgcgctc  ggatggtgg  gcggccagc  ccgaggccg  tcctgggac  3360
aggacagga  atggttcga  acctgggat  aggaagtcg  gggcacttt  tcaaactgg  3420
gtttcgagg  cgacggaac  gacaaggat  caaatttct  tgtggcctt  gagaacgtg  3480
caccactat  aaggtgcac  tcaagagac  cgagatgac  tcgtcctca  tgtgagcct  3540
cggggcccc  tcaccaccc  ctccgccct  ccccggaca  aagggtctg  attgcgtcc  3600
tttcaagag  tgaccccag  acgcgggca  cccaggctc  tgctgttct  gggcaagat  3660
agactgttc  cccaaatcc  atccttctc  ttccaactt  gctgaaacc  acctggaga  3720
gcagttcac  tccaggctc  tccactgtg  aatcttggg  aagtcagta  cgagcctca  3780
tttcctcac  tgcaaaacg  gtacagcat  cctgtatga  acgtcacgc  gttgttgtg  3840
aaaccacat  gacttggtc  attctcggt  ctactctgc  ctcccgtct  agccctcgt  3900
ttgccattg  ctctctcgg  tcctccaat  ctcacgtcc  tcacctggt  tctggccct  3960
gttcttatt  tctctcaat  ccctactgc  tgtttctta  tttgaacct  gaggcagcc  4020
gcagcccca  cccatctcc  gccctctcc  gatctaact  cctgctgca  ctcttgctc  4080
cattcctta  acgtcctcc  cttttgacc  cgttccttc  tccatcctg  accccagtc  4140
cccagccct  aatcctccc  cctctcctc  catcctggc  cctagcaag  tatagatag  4200
ctctgtgtc  taggatacc  cgggtgctg  tccctcggt  atcctgttg  ccagttccc  4260
gtttctctt  ctctcattc  tgtatcctt  ccccttttg  gcccgtcca  tcatcggtt  4320
tgcccccga  tcccccagc  ctaaatacc  cagctgctg  tccccccat  accctgctg  4380
ccaattctt  attctccac  cctttctct  acccctgga  ccctgcggg  gggggcagg  4440
catgagttc  ccagtcccc  aggaaaggc  gccccctca  tctccctcc  cctcattcc  4500
ttccatctc  ctcccctct  ccttttaaa  ccatcccct  cgattcccc  cctcccccc  4560
ctctccctg  tgtcacctg  attcctgca  taattctga  cccttgaaa  cctcagtcg  4620
cttggcggg  aagattggc  ttggggaca  gaggtcggc  catctccag  tcttcatgt  4680
cgcaatata  agtttattg  aaaaagc  4707



<210> 3913
<211> 957
<212> PRT
<213> Homo sapiens
<308> AAC02272
<400> 3913

Ile Thr Ile Thr Glu Thr Thr Ser His Ser Thr Pro Ser Tyr Thr Thr 
  1               5                  10                  15
Ser Ile Thr Thr Thr Glu Thr Pro Ser His Ser Thr Pro Ser Tyr Thr 
             20                  25                  30
Thr Ser Ile Thr Thr Thr Glu Thr Pro Ser His Ser Thr Pro Ser Phe 
         35                  40                  45
Thr Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser His Ser Thr Pro Ser 
     50                  55                  60
Phe Thr Ser Ser Ile Arg Thr Thr Glu Thr Thr Ser Tyr Ser Thr Pro 
 65                  70                  75                  80
Ser Phe Thr Ser Ser Asn Thr Ile Thr Glu Thr Thr Ser His Ser Thr 
                 85                  90                  95
Pro Ser Tyr Ile Thr Ser Ile Thr Thr Thr Glu Thr Pro Ser Ser Ser 
             100                105                110
Thr Pro Ser Phe Ser Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser His 
         115                120                125
Ser Thr Pro Gly Phe Thr Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser 
     130                135                140
His Ser Thr Pro Ser Phe Thr Ser Ser Ile Thr Thr Thr Glu Thr Thr 
 145                150                155                160
Ser His Asp Thr Pro Ser Phe Thr Ser Ser Ile Thr Thr Ser Glu Thr 
                 165                170                175
Pro Ser His Ser Thr Pro Ser Ser Thr Ser Leu Ile Thr Thr Thr Lys 
             180                185                190
Thr Thr Ser His Ser Thr Pro Ser Phe Thr Ser Ser Ile Thr Thr Thr 
         195                200                205
Glu Thr Thr Ser His Ser Ala Arg Ser Phe Thr Ser Ser Ile Thr Thr 
     210                215                220
Thr Glu Thr Thr Ser His Asn Thr Arg Ser Phe Thr Ser Ser Ile Thr 
 225                230                235                240
Thr Thr Glu Thr Asn Ser His Ser Thr Thr Ser Phe Thr Ser Ser Ile 
                 245                250                255
Thr Thr Thr Glu Thr Thr Ser His Ser Thr Pro Ser Phe Ser Ser Ser 
             260                265                270
Ile Thr Thr Thr Glu Thr Pro Leu His Ser Thr Pro Gly Leu Pro Ser 
         275                280                285
Trp Val Thr Thr Thr Lys Thr Thr Ser His Ile Thr Pro Gly Leu Thr 
     290                295                300
Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser His Ser Thr Pro Gly Phe 
 305                310                315                320
Thr Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser Glu Ser Thr Pro Ser 
                 325                330                335
Leu Ser Ser Ser Thr Ile Tyr Ser Thr Val Ser Thr Ser Thr Thr Ala 
             340                345                350
Ile Thr Ser His Phe Thr Thr Ser Glu Thr Ala Val Thr Pro Thr Pro 
         355                360                365
Val Thr Pro Ser Ser Leu Ser Thr Asp Ile Pro Thr Thr Ser Leu Arg 
     370                375                380
Thr Leu Thr Pro Ser Ser Val Gly Thr Ser Thr Ser Leu Thr Thr Thr 
 385                390                395                400
Thr Asp Phe Pro Ser Ile Pro Thr Asp Ile Ser Thr Leu Pro Thr Arg 
                 405                410                415
Thr His Ile Ile Ser Ser Ser Pro Ser Ile Gln Ser Thr Glu Thr Ser 
             420                425                430
Ser Leu Val Gly Thr Thr Ser Pro Thr Met Ser Thr Val Arg Met Thr 
         435                440                445
Leu Arg Ile Thr Glu Asn Thr Pro Ile Ser Ser Phe Ser Thr Ser Ile 
     450                455                460
Val Val Ile Pro Glu Thr Pro Thr Gln Thr Pro Pro Val Leu Thr Ser 
 465                470                475                480
Ala Thr Gly Thr Gln Thr Ser Pro Ala Pro Thr Thr Val Thr Phe Gly 
                 485                490                495
Ser Thr Asp Ser Ser Thr Ser Thr Leu His Thr Leu Thr Pro Ser Thr 
             500                505                510
Ala Leu Ser Thr Ile Val Ser Thr Ser Gln Val Pro Ile Pro Ser Thr 
         515                520                525
His Ser Ser Thr Leu Gln Thr Thr Pro Ser Thr Pro Ser Leu Gln Thr 
     530                535                540
Ser Leu Thr Ser Thr Ser Glu Phe Thr Thr Glu Ser Phe Thr Arg Gly 
 545                550                555                560
Ser Thr Ser Thr Asn Ala Ile Leu Thr Ser Phe Ser Thr Ile Ile Trp 
                 565                570                575
Ser Ser Thr Pro Thr Ile Ile Met Ser Ser Ser Pro Ser Ser Ala Ser 
             580                585                590
Ile Thr Pro Val Phe Ser Thr Thr Ile His Ser Val Pro Ser Ser Pro 
         595                600                605
Tyr Ile Phe Ser Thr Glu Asn Val Gly Ser Ala Ser Ile Thr Gly Phe 
     610                615                620
Pro Ser Leu Ser Ser Ser Ala Thr Thr Ser Thr Ser Ser Thr Ser Ser 
 625                630                635                640
Ser Leu Thr Thr Ala Leu Thr Glu Ile Thr Pro Phe Ser Tyr Ile Ser 
                 645                650                655
Leu Pro Ser Thr Thr Pro Cys Pro Gly Thr Ile Thr Ile Thr Ile Val 
             660                665                670
Pro Ala Ser Pro Thr Asp Pro Cys Val Glu Met Asp Pro Ser Thr Glu 
         675                680                685
Ala Thr Ser Pro Pro Thr Thr Pro Leu Thr Val Phe Pro Phe Thr Thr 
     690                695                700
Glu Met Val Thr Cys Pro Thr Ser Ile Ser Ile Gln Thr Thr Leu Thr 
 705                710                715                720
Thr Tyr Met Asp Thr Ser Ser Met Met Pro Glu Ser Glu Ser Ser Ile 
                 725                730                735
Ser Pro Asn Ala Ser Ser Ser Thr Gly Thr Gly Thr Val Pro Thr Asn 
             740                745                750
Thr Val Phe Thr Ser Thr Arg Leu Pro Thr Ser Glu Thr Trp Leu Ser 
         755                760                765
Asn Ser Ser Val Ile Pro Leu Pro Leu Pro Gly Val Ser Thr Ile Pro 
     770                775                780
Leu Thr Met Lys Pro Ser Ser Ser Leu Pro Thr Ile Leu Arg Thr Ser 
 785                790                795                800
Ser Lys Ser Thr His Pro Ser Pro Pro Thr Thr Arg Thr Ser Glu Thr 
                 805                810                815
Pro Val Ala Thr Thr Gln Thr Pro Thr Thr Leu Thr Ser Arg Arg Thr 
             820                825                830
Thr Arg Ile Thr Ser Gln Met Thr Thr Gln Ser Thr Leu Thr Thr Thr 
         835                840                845
Ala Gly Thr Cys Asp Asn Gly Gly Thr Trp Glu Gln Gly Gln Cys Ala 
     850                855                860
Cys Leu Pro Gly Phe Ser Gly Asp Arg Cys Gln Leu Gln Thr Arg Cys 
 865                870                875                880
Gln Asn Gly Gly Gln Trp Asp Gly Leu Lys Cys Gln Cys Pro Ser Thr 
                 885                890                895
Phe Tyr Gly Ser Ser Cys Glu Phe Ala Val Glu Gln Val Asp Leu Asp 
             900                905                910
Ala Glu Asp Phe Cys Arg His Ala Gly Leu His Leu Gln Gly Cys Gly 
         915                920                925
Asp Pro Val Pro Glu Glu Trp Gln His Arg Gly Gly Leu Pro Gly Pro 
     930                935                940
Ala Gly Asp Ala Leu Gln Pro Pro Ala Gly Glu Arg Val 
 945                950                955



<210> 3914
<211> 1341
<212> DNA
<213> Rattus norvegicus
<308> M76740
<400> 3914

ggcaccacc  ctgttgatt  cacgaccac  gctgagttc  ccaccactc  tgatgtcac  60
accactcct  atgtgacca  cacccctgg  gtcaccacc  ctgctggtg  caccaccac  120
cctgatgtc  ccaccactg  tggtgtcac  accactcct  acgtcacca  cactgctga  180
gtcaccacc  ctcctgatg  gaccaccac  gctgatgtc  ccaccactg  tggtatcac  240
accactcct  atgtgacca  cactgctgg  gtcaccacc  ctcctgatg  caccaccac  300
cctgatgtc  ccaccactc  tgatgtcac  accactcct  atgtcacca  cactcctga  360
gtcaccacc  ctcctgata  aaccaccac  cctgataca  ccaccactc  tcaggtcac  420
accactgtt  atgtcacga  cactgttga  gtcaccacc  ctgctgagg  caccaccac  480
actgaggtc  ccacctctc  tgatgcaac  accactact  acgtcacca  cactcctga  540
gcaaccacc  ctgatggtg  caccaccac  cctgatgtc  ccaccactt  tgatgtgac  600
accactgct  atgtcacca  cactgctag  gtcaccacc  ctcctgatg  caccaccac  660
cctgatgtc  ccaccactc  tgatgtgac  accactgct  gtgtcacca  cactcctga  720
gccaccacc  ctcctgatg  aaccaccac  cctcaggtc  ccaccactg  tgatgtcac  780
accactgct  gtgtcacca  cactgctgg  gtcaccacc  ctccagatg  caccacgac  840
cctgatgtg  ccaccactc  tgacgtcac  accactgct  gtgtcacca  cactgctga  900
gtcaccacc  ctcctgaag  caccaccac  cctgaggtc  ccaccactc  tgctgtcac  960
accacgcct  gtgtcacta  cactcctgc  gtcactacg  cacgtgtca  caccaccat  1020
cctgtcatc  ctactacgc  tgtcatgac  accactcca  tgaattgcc  gaacggagg  1080
tactggtca  gtgcgatgt  cgtctgccc  aatggcttc  caggggatc  ctgtcagaa  1140
agagtccct  tggtcgact  ccagaacgg  ggcacgtgg  atgggctca  atgtcagtg  1200
accggcctc  tctatggcc  aaggtgtga  gaagtgatg  agagcgtag  gataaagcc  1260
acggtctct  catctgtgg  agtgagtgt  acagtaacc  gtcaagaat  tagtaatga  1320
ctacaggac  gaaactcca  a  1341



<210> 3915
<211> 447
<212> PRT
<213> Rattus norvegicus
<308> AAA41642
<400> 3915

Gly Thr Thr Thr Val Asp Phe Thr Thr Thr Ala Glu Phe Thr Thr Thr 
  1               5                  10                  15
Pro Asp Val Thr Thr Thr Pro Asp Val Thr Thr Thr Pro Gly Val Thr 
             20                  25                  30
Thr Thr Ala Gly Val Thr Thr Thr Pro Asp Val Thr Thr Thr Ala Gly 
         35                  40                  45
Val Thr Thr Thr Pro Asp Val Thr Thr Thr Ala Asp Val Thr Thr Thr 
     50                  55                  60
Pro Asp Val Thr Thr Thr Ala Asp Val Thr Thr Thr Ala Gly Ile Thr 
 65                  70                  75                  80
Thr Thr Pro Asp Val Thr Thr Thr Ala Gly Val Thr Thr Thr Pro Asp 
                 85                  90                  95
Val Thr Thr Thr Pro Asp Val Thr Thr Thr Pro Asp Val Thr Thr Thr 
             100                105                110
Pro Asp Val Thr Thr Thr Pro Asp Val Thr Thr Thr Pro Asp Thr Thr 
         115                120                125
Thr Thr Pro Asp Thr Thr Thr Thr Pro Gln Val Thr Thr Thr Val Asp 
     130                135                140
Val Thr Thr Thr Val Asp Val Thr Thr Thr Ala Glu Val Thr Thr Thr 
 145                150                155                160
Thr Glu Val Thr Thr Ser Pro Asp Ala Thr Thr Thr Thr Asp Val Thr 
                 165                170                175
Thr Thr Pro Glu Ala Thr Thr Thr Asp Gly Val Thr Thr Thr Pro Asp 
             180                185                190
Val Thr Thr Thr Ser Asp Val Thr Thr Thr Ala Asp Val Thr Thr Thr 
         195                200                205
Ala Ser Val Thr Thr Thr Pro Asp Val Thr Thr Thr Pro Asp Val Thr 
     210                215                220
Thr Thr Pro Asp Val Thr Thr Thr Ala Gly Val Thr Thr Thr Pro Asp 
 225                230                235                240
Ala Thr Thr Thr Pro Asp Ala Thr Thr Thr Pro Gln Val Thr Thr Thr 
                 245                250                255
Ala Asp Val Thr Thr Thr Ala Gly Val Thr Thr Thr Ala Gly Val Thr 
             260                265                270
Thr Thr Pro Asp Val Thr Thr Thr Pro Asp Val Thr Thr Thr Pro Asp 
         275                280                285
Val Thr Thr Thr Ala Ser Val Thr Thr Thr Ala Asp Val Thr Thr Thr 
     290                295                300
Pro Glu Val Thr Thr Thr Pro Glu Val Thr Thr Thr Pro Ala Val Thr 
 305                310                315                320
Thr Thr Pro Arg Val Thr Thr Thr Pro Ala Val Thr Thr Thr Arg Val 
                 325                330                335
Ile Thr Thr Met Pro Val Ile Thr Thr Thr Pro Val Met Thr Thr Thr 
             340                345                350
Pro Val Asn Cys Leu Asn Gly Gly Tyr Trp Ser Gly Ala Met Cys Val 
         355                360                365
Cys Pro Asn Gly Phe Ser Gly Asp Arg Cys Gln Asn Arg Val Pro Val 
     370                375                380
Val Asp Cys Gln Asn Gly Gly Thr Trp Asp Gly Leu Lys Cys Gln Cys 
 385                390                395                400
Thr Gly Leu Phe Tyr Gly Pro Arg Cys Glu Glu Val Met Glu Ser Val 
                 405                410                415
Glu Ile Lys Pro Thr Val Ser Ala Ser Val Glu Val Ser Val Thr Val 
             420                425                430
Thr Ser Gln Glu Tyr Ser Asn Glu Leu Gln Asp Arg Asn Ser Thr 
         435                440                445



<210> 3916
<211> 4707
<212> DNA
<213> Homo sapiens
<308> AF007194
<400> 3916

gatcaccat  accgagacc  cctcacaca  tactcccag  tacactacc  caatcacca  60
caccgagac  ccctcacac  gtactccca  ctacactac  tcaatcacc  ccaccgaga  120
cccatcaca  agtactccc  gcttcactt  ttcaatcac  accaccgag  ccacatccc  180
cagtactcc  agcttcact  cttcaatca  gaccaccga  accacatcc  acagtactc  240
cagcttcac  tcttcaaat  ccatcactg  gaccacctc  cacagtact  ccagctaca  300
tacctcaat  accaccacc  agaccccct  aagcagtac  cccagcttc  gttcttcga  360
caccaccac  gagaccaca  cccacagta  tcccggctt  acttcttca  tcaccacca  420
tgagactac  tcccacagt  ctcccagct  cacttcttc  atcaccacc  ctgagacca  480
ctcacatga  actcccagc  tcacttctt  aatcaccac  agtgagacc  cctcacaca  540
tactcccag  tccacttct  taatcacca  caccaagac  acctcacac  gtactccca  600
cttcacttc  tcgatcacc  ccaccgaga  cacctcaca  agtgctcgc  gcttcactt  660
ttcgatcac  accaccgag  ccacctcac  caatactcg  agcttcact  cttcgatca  720
caccaccga  accaactct  acagtacta  cagcttcac  tcttcgatc  ccaccaccg  780
gaccacctc  cacagtact  ccagcttca  ttcttcaat  accaccact  agaccccct  840
acacagtac  cctggccta  cttcgtggg  caccaccac  aagaccacc  cacacatta  900
tcctggcct  acttcttca  tcaccacca  tgagactac  tcacacagt  ctcccggct  960
cacttcttc  atcaccacc  ctgagacca  ctcagagag  actcccagc  tcagttctt  1020
aaccatcta  tccacagtc  gcacatcca  aactgccat  acctcacat  ttactacct  1080
agagactgc  gtgactccc  cacctgtaa  cccatcttc  ctgagtaca  acatcccga  1140
cacaagcct  cgaactctc  ccccttcgt  tgtgggcac  agcacttca  tgactacaa  1200
cacagactt  ccctctata  ccactgata  cagtacctt  ccaactcga  cacacatca  1260
ttcatcttc  ccctccatc  aaagtacag  aacctcatc  cttgtgggc  ccacctctc  1320
caccatgtc  actgtgaga  tgaccctca  aattactga  aacacccca  tcagttcct  1380
tagcacaag  attgttgtt  tacctgaaa  cccaacaca  acccctcct  tactgacgt  1440
agccactgg  acccaaaca  ctcctgcac  tactactgt  acctttgga  gtacggatt  1500
ctccacgtc  actcttcat  ctcttactc  atcaacagc  ttgagcacg  tcgtgtcaa  1560
atcacaggt  cctattcct  gcacacatt  ctccaccct  caaacaact  cttctactc  1620
ctcattgca  acttcactc  catctacaa  tgagttcac  acagaatct  tcactaggg  1680
aagtacgtc  acaaatgca  tcttgactt  ttttagtac  atcatctgg  cctcaacac  1740
cactattat  atgtcctct  ctccatctt  tgccagcat  actccagtg  tctccacta  1800
cattcattc  gttccttct  caccataca  tttcagtac  gaaaatgtg  gctccgctt  1860
tatcacagg  tttcctagt  tctcttcct  tgcaactac  agcacttct  caaccagct  1920
ctctctgac  acagctctc  ctgaaataa  ccccttttc  tatatttcc  ttccctcca  1980
cacaccctg  ccaggaact  taacaatta  catagtccc  gcctctccc  ctgatccat  2040
tgttgaaat  gatcccagc  ctgaagcta  ttctcctcc  accacccca  taacagtct  2100
tccctttac  accgaaatg  tcacctgtc  tacctccat  agtatccaa  ctactctta  2160
tacatatat  gacacttct  ccatgatgc  agaaagtga  tccagcatc  cacccaatg  2220
ttccagttc  actggcact  ggactgtac  cacaaacac  gttttcaca  gtactcgac  2280
gcccaccag  gagacctgg  tgagcaaca  ttctgtgat  cccctacct  ttcctggcg  2340
ctctaccat  ccgctcacc  tgaaaccaa  cagtagcct  ccgaccatc  tgaggactt  2400
aagcaagtc  acacaccca  ccccaccca  cactaggac  tcagagaca  cagtggcca  2460
tacccagac  cctaccacc  ttacatcac  caggacaac  cgcatcact  ctcagatga  2520
cacacagtc  acgttgacc  ccactgcag  cacctgtga  aatggtggc  cctgggaac  2580
gggccagtg  gcttgcctt  cggggtttt  tggggaccg  tgtcagctc  agaccagat  2640
ccagaatgg  ggtcagtgg  atggcctca  atgccagtg  cccagcacc  tctatggtt  2700
cagttgtga  tttgctgtg  aacaggtgg  tctagatgc  gaagatttt  gcagacatg  2760
agggcttca  cttcaaggg  gtggagatc  tgtccctga  gaatggcag  atcgtggtg  2820
actacctgg  cctgctgga  atgcccttc  gcccccagc  ggagagcga  tatgagcag  2880
tgaagacca  gctgaagga  gggctgcag  acgccagcc  ggatgtgaa  agctgccag  2940
actcccaga  cctgtgttt  aagcctgac  ccatcaagg  gaacaacaa  agcaagaca  3000
agctgaccc  ggcagccat  tgccgcgcg  cgctcccac  ggctatgaa  agttctact  3060
ccccttggt  gaggccacc  ggctccgct  tgtcaccaa  tgcacgtct  gggtggaca  3120
cgccatcga  tgtcaccag  gccagtgcg  tctggagac  agcggtccc  cgtgtcgct  3180
ctactccac  gacacgcac  ggttctctg  cccgcgctg  gaggtggcc  tccactgga  3240
ggcgctggt  ggggcctga  ggccggcgc  cgctgctgg  gctgctgct  gtggcgctg  3300
gcgtccggg  ggtgcgctc  ggatggtgg  gcggccagc  ccgaggccg  tcctgggac  3360
aggacagga  atggttcga  acctgggat  aggaagtcg  gggcacttt  tcaaactgg  3420
gtttcgagg  cgacggaac  gacaaggat  caaatttct  tgtggcctt  gagaacgtg  3480
caccactat  aaggtgcac  tcaagagac  cgagatgac  tcgtcctca  tgtgagcct  3540
cggggcccc  tcaccaccc  ctccgccct  ccccggaca  aagggtctg  attgcgtcc  3600
tttcaagag  tgaccccag  acgcgggca  cccaggctc  tgctgttct  gggcaagat  3660
agactgttc  cccaaatcc  atccttctc  ttccaactt  gctgaaacc  acctggaga  3720
gcagttcac  tccaggctc  tccactgtg  aatcttggg  aagtcagta  cgagcctca  3780
tttcctcac  tgcaaaacg  gtacagcat  cctgtatga  acgtcacgc  gttgttgtg  3840
aaaccacat  gacttggtc  attctcggt  ctactctgc  ctcccgtct  agccctcgt  3900
ttgccattg  ctctctcgg  tcctccaat  ctcacgtcc  tcacctggt  tctggccct  3960
gttcttatt  tctctcaat  ccctactgc  tgtttctta  tttgaacct  gaggcagcc  4020
gcagcccca  cccatctcc  gccctctcc  gatctaact  cctgctgca  ctcttgctc  4080
cattcctta  acgtcctcc  cttttgacc  cgttccttc  tccatcctg  accccagtc  4140
cccagccct  aatcctccc  cctctcctc  catcctggc  cctagcaag  tatagatag  4200
ctctgtgtc  taggatacc  cgggtgctg  tccctcggt  atcctgttg  ccagttccc  4260
gtttctctt  ctctcattc  tgtatcctt  ccccttttg  gcccgtcca  tcatcggtt  4320
tgcccccga  tcccccagc  ctaaatacc  cagctgctg  tccccccat  accctgctg  4380
ccaattctt  attctccac  cctttctct  acccctgga  ccctgcggg  gggggcagg  4440
catgagttc  ccagtcccc  aggaaaggc  gccccctca  tctccctcc  cctcattcc  4500
ttccatctc  ctcccctct  ccttttaaa  ccatcccct  cgattcccc  cctcccccc  4560
ctctccctg  tgtcacctg  attcctgca  taattctga  cccttgaaa  cctcagtcg  4620
cttggcggg  aagattggc  ttggggaca  gaggtcggc  catctccag  tcttcatgt  4680
cgcaatata  agtttattg  aaaaagc  4707



<210> 3917
<211> 957
<212> PRT
<213> Homo sapiens
<308> AAC02272
<400> 3917

Ile Thr Ile Thr Glu Thr Thr Ser His Ser Thr Pro Ser Tyr Thr Thr 
  1               5                  10                  15
Ser Ile Thr Thr Thr Glu Thr Pro Ser His Ser Thr Pro Ser Tyr Thr 
             20                  25                  30
Thr Ser Ile Thr Thr Thr Glu Thr Pro Ser His Ser Thr Pro Ser Phe 
         35                  40                  45
Thr Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser His Ser Thr Pro Ser 
     50                  55                  60
Phe Thr Ser Ser Ile Arg Thr Thr Glu Thr Thr Ser Tyr Ser Thr Pro 
 65                  70                  75                  80
Ser Phe Thr Ser Ser Asn Thr Ile Thr Glu Thr Thr Ser His Ser Thr 
                 85                  90                  95
Pro Ser Tyr Ile Thr Ser Ile Thr Thr Thr Glu Thr Pro Ser Ser Ser 
             100                105                110
Thr Pro Ser Phe Ser Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser His 
         115                120                125
Ser Thr Pro Gly Phe Thr Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser 
     130                135                140
His Ser Thr Pro Ser Phe Thr Ser Ser Ile Thr Thr Thr Glu Thr Thr 
 145                150                155                160
Ser His Asp Thr Pro Ser Phe Thr Ser Ser Ile Thr Thr Ser Glu Thr 
                 165                170                175
Pro Ser His Ser Thr Pro Ser Ser Thr Ser Leu Ile Thr Thr Thr Lys 
             180                185                190
Thr Thr Ser His Ser Thr Pro Ser Phe Thr Ser Ser Ile Thr Thr Thr 
         195                200                205
Glu Thr Thr Ser His Ser Ala Arg Ser Phe Thr Ser Ser Ile Thr Thr 
     210                215                220
Thr Glu Thr Thr Ser His Asn Thr Arg Ser Phe Thr Ser Ser Ile Thr 
 225                230                235                240
Thr Thr Glu Thr Asn Ser His Ser Thr Thr Ser Phe Thr Ser Ser Ile 
                 245                250                255
Thr Thr Thr Glu Thr Thr Ser His Ser Thr Pro Ser Phe Ser Ser Ser 
             260                265                270
Ile Thr Thr Thr Glu Thr Pro Leu His Ser Thr Pro Gly Leu Pro Ser 
         275                280                285
Trp Val Thr Thr Thr Lys Thr Thr Ser His Ile Thr Pro Gly Leu Thr 
     290                295                300
Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser His Ser Thr Pro Gly Phe 
 305                310                315                320
Thr Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser Glu Ser Thr Pro Ser 
                 325                330                335
Leu Ser Ser Ser Thr Ile Tyr Ser Thr Val Ser Thr Ser Thr Thr Ala 
             340                345                350
Ile Thr Ser His Phe Thr Thr Ser Glu Thr Ala Val Thr Pro Thr Pro 
         355                360                365
Val Thr Pro Ser Ser Leu Ser Thr Asp Ile Pro Thr Thr Ser Leu Arg 
     370                375                380
Thr Leu Thr Pro Ser Ser Val Gly Thr Ser Thr Ser Leu Thr Thr Thr 
 385                390                395                400
Thr Asp Phe Pro Ser Ile Pro Thr Asp Ile Ser Thr Leu Pro Thr Arg 
                 405                410                415
Thr His Ile Ile Ser Ser Ser Pro Ser Ile Gln Ser Thr Glu Thr Ser 
             420                425                430
Ser Leu Val Gly Thr Thr Ser Pro Thr Met Ser Thr Val Arg Met Thr 
         435                440                445
Leu Arg Ile Thr Glu Asn Thr Pro Ile Ser Ser Phe Ser Thr Ser Ile 
     450                455                460
Val Val Ile Pro Glu Thr Pro Thr Gln Thr Pro Pro Val Leu Thr Ser 
 465                470                475                480
Ala Thr Gly Thr Gln Thr Ser Pro Ala Pro Thr Thr Val Thr Phe Gly 
                 485                490                495
Ser Thr Asp Ser Ser Thr Ser Thr Leu His Thr Leu Thr Pro Ser Thr 
             500                505                510
Ala Leu Ser Thr Ile Val Ser Thr Ser Gln Val Pro Ile Pro Ser Thr 
         515                520                525
His Ser Ser Thr Leu Gln Thr Thr Pro Ser Thr Pro Ser Leu Gln Thr 
     530                535                540
Ser Leu Thr Ser Thr Ser Glu Phe Thr Thr Glu Ser Phe Thr Arg Gly 
 545                550                555                560
Ser Thr Ser Thr Asn Ala Ile Leu Thr Ser Phe Ser Thr Ile Ile Trp 
                 565                570                575
Ser Ser Thr Pro Thr Ile Ile Met Ser Ser Ser Pro Ser Ser Ala Ser 
             580                585                590
Ile Thr Pro Val Phe Ser Thr Thr Ile His Ser Val Pro Ser Ser Pro 
         595                600                605
Tyr Ile Phe Ser Thr Glu Asn Val Gly Ser Ala Ser Ile Thr Gly Phe 
     610                615                620
Pro Ser Leu Ser Ser Ser Ala Thr Thr Ser Thr Ser Ser Thr Ser Ser 
 625                630                635                640
Ser Leu Thr Thr Ala Leu Thr Glu Ile Thr Pro Phe Ser Tyr Ile Ser 
                 645                650                655
Leu Pro Ser Thr Thr Pro Cys Pro Gly Thr Ile Thr Ile Thr Ile Val 
             660                665                670
Pro Ala Ser Pro Thr Asp Pro Cys Val Glu Met Asp Pro Ser Thr Glu 
         675                680                685
Ala Thr Ser Pro Pro Thr Thr Pro Leu Thr Val Phe Pro Phe Thr Thr 
     690                695                700
Glu Met Val Thr Cys Pro Thr Ser Ile Ser Ile Gln Thr Thr Leu Thr 
 705                710                715                720
Thr Tyr Met Asp Thr Ser Ser Met Met Pro Glu Ser Glu Ser Ser Ile 
                 725                730                735
Ser Pro Asn Ala Ser Ser Ser Thr Gly Thr Gly Thr Val Pro Thr Asn 
             740                745                750
Thr Val Phe Thr Ser Thr Arg Leu Pro Thr Ser Glu Thr Trp Leu Ser 
         755                760                765
Asn Ser Ser Val Ile Pro Leu Pro Leu Pro Gly Val Ser Thr Ile Pro 
     770                775                780
Leu Thr Met Lys Pro Ser Ser Ser Leu Pro Thr Ile Leu Arg Thr Ser 
 785                790                795                800
Ser Lys Ser Thr His Pro Ser Pro Pro Thr Thr Arg Thr Ser Glu Thr 
                 805                810                815
Pro Val Ala Thr Thr Gln Thr Pro Thr Thr Leu Thr Ser Arg Arg Thr 
             820                825                830
Thr Arg Ile Thr Ser Gln Met Thr Thr Gln Ser Thr Leu Thr Thr Thr 
         835                840                845
Ala Gly Thr Cys Asp Asn Gly Gly Thr Trp Glu Gln Gly Gln Cys Ala 
     850                855                860
Cys Leu Pro Gly Phe Ser Gly Asp Arg Cys Gln Leu Gln Thr Arg Cys 
 865                870                875                880
Gln Asn Gly Gly Gln Trp Asp Gly Leu Lys Cys Gln Cys Pro Ser Thr 
                 885                890                895
Phe Tyr Gly Ser Ser Cys Glu Phe Ala Val Glu Gln Val Asp Leu Asp 
             900                905                910
Ala Glu Asp Phe Cys Arg His Ala Gly Leu His Leu Gln Gly Cys Gly 
         915                920                925
Asp Pro Val Pro Glu Glu Trp Gln His Arg Gly Gly Leu Pro Gly Pro 
     930                935                940
Ala Gly Asp Ala Leu Gln Pro Pro Ala Gly Glu Arg Val 
 945                950                955



<210> 3918
<211> 3679
<212> DNA
<213> Rattus norvegicus
<308> M77245
<400> 3918

tgacatggt  aagagtctg  ccacagata  aggaccgaa  tgactgact  aaaatactt  60
acaacaacc  agaaagggg  gatcttcga  ttgaaggca  agcttaaca  tgacaagaa  120
gagaagaag  aggaggcag  aaagaaagt  attgcatca  tgaccgtgg  caaagatgt  180
agtgctctc  tccctgatg  ggtgaactg  atgcagaca  acaacctgg  gctaaagaa  240
ctggtgtac  tgtacttga  gaactatgc  aagagtcag  ctgacatgg  cattatggc  300
gtcaacacc  tcgtgaagg  ctgtgagga  cccaacccc  ttatccggg  cctggctgt  360
aggactatg  gctgcatcc  agttgacaa  atcacagag  acttgtgtg  accactccg  420
aaatgcctg  aggatgaag  cccatatgt  cgcaagaca  cagctgtgt  tgtagccaa  480
ctccacgac  tcaacgccc  gctggtaga  gaccagggt  tcctggaca  actcaaaga  540
ctcatctct  actctaacc  catggtggt  gcaaatcga  tggctgccc  gtcagagat  600
gctgagtct  accccagta  caacctgct  gacttgaag  cacagtcta  caacaagct  660
ctgacggcc  ttaatgagt  caccgagtg  gcccagatc  tcattctgg  ctgtctggg  720
aactacatg  ccaaggatg  ccgtgaggc  cagagcatc  gcgagcggg  cactcctag  780
ctttcccat  ccaactctg  tgtggtgct  tccgcagtg  aggtcctga  gaagttcat  840
gagatgctg  ctaaggacc  ggactacta  gccacacta  tcaagaagc  ggcccctcc  900
ctggtcacc  tgctgtcag  agagccaga  ccgcagtat  tgcctctgc  caatattaa  960
ctcattgta  agaaaaggc  agagatttt  aagcatgaa  tgaaggttt  ctttgtgaa  1020
tacaatgac  ccatctatg  gaagctgga  aaactggac  ttatgatcc  cctggcctc  1080
caggccaac  ttgcccagg  tttggcaga  ctcaaagag  acgcgacag  agtagatgt  1140
gattttgta  ggaaggcag  gcgtgccat  ggccgctgt  ccatcaagg  ggagcaatc  1200
gcagagcgc  gtgtgagca  attgcttga  ctcatccag  ccaaggtca  ctatgtggt  1260
caggaagcc  ttgtggtca  taaagacat  ttccgcaag  accccaaca  gtacgagag  1320
gtgatagcc  cactgtgtg  gaatctgga  tcgctggat  agcctgagg  tcgcgctgc  1380
atgatctgg  tagtgggcg  gtatgctga  cggattgac  atgcggacg  gctgcttga  1440
agcttcctc  acggcttcc  tgacgagag  acccaggtc  agctacagc  gctgacagc  1500
attgtgaag  tcttcctga  gaagccaac  gagacgcag  agctggtgc  gcaggtcct  1560
agtttggcc  ctcaggact  ggacaatcc  gaccttcgg  accgtggct  catctactg  1620
cgcctgctc  ccacggacc  tgtagctgc  aaagaggtg  tactggctg  gaagcccct  1680
atctcagaa  agacagacc  tattgagcc  acactgctg  atgaactca  ctgctacat  1740
ggcacactg  cctctgtct  ccacaagcc  cccaatgcc  ttgtggagg  cggccgggg  1800
gtggtgcac  agagtctgc  acctcgcac  gcctcgagc  aaagcacag  gagccctga  1860
gcagcccct  ccggagcac  tgctagtga  cagcctgat  tcattcctg  ccagggtga  1920
ctgttaggt  acctcctca  cctggacct  gggccccca  tgagtggcc  acccttggc  1980
gcctcctca  tgcagatgg  agctgtgga  cttcttggt  gtggcctcg  cagcctgat  2040
ggggatgag  ctgaaggga  tggagacag  aactttggg  cacctccag  atcagtggc  2100
gcggcagca  cagccagac  tggagcacc  gtcagcagt  gcttaagtg  cctctttga  2160
ctgaccagt  gagtgggca  cctctcagg  tcctatgtc  ctcccaaag  agtttggct  2220
cctgccatg  aggccaagg  gctggaaat  tctggcacc  tcacccggc  ggttggctc  2280
atctccatg  atctgcagc  gactaacaa  gccctgcag  tcatgacag  tttcgctat  2340
cagtttaat  ggaacagct  tggcttggc  cccgctgcg  cactccaag  gcacgcccc  2400
ctgagcccc  accagacgg  ggagatctc  ctgcctctt  acacggtgg  ctcagtcat  2460
aagatggag  ctctgaaca  tcttcaggt  gctgtgaag  acaacattg  cgtcttcta  2520
ttcagcact  tgtacccac  gcatgtcct  ttcgtggag  acgggaaga  ggaccggca  2580
atgttcctg  ccacatgga  ggacattcc  aacgagaat  aagcccagt  ccagatcag  2640
gactgcccg  tgaacacag  ggctgcaag  agcaagctg  aaagcagta  cattttcac  2700
gtcgccaag  ggactgtgg  gggccagga  atgctctac  aatctctga  gttgaccaa  2760
ggcatctgg  tgctggcag  gctgcggat  cagccaggc  accccagtt  cacgctgtc  2820
ctgaagtgt  gagccccag  ggtgtccca  catgatatc  aggcctacg  gaccatcct  2880
aagaactga  gtccctctc  ctccacccc  gccttctcc  tctgccagc  cagccatgg  2940
accctgtgg  ggcagcacc  cctcctttc  ttggggaga  gccagtggg  tcctgaccc  3000
cccaggagg  ctcccctga  cctaactga  ggcctggag  agggccagg  ctcctagag  3060
gaaatctcc  tgcatctcc  gtggctgct  ttttctatt  ctgttgatg  gggatcaaa  3120
gaagtggat  cagcacagc  tcagaagct  gacgggggc  acagggtgc  cttccttcc  3180
tctgctctc  tggggtgaa  atggaaccc  cctggggtc  cagcccata  tccctgccc  3240
gtctcctca  tgagcctgt  tgggtagag  cctctgggt  ccaatatta  tgtttggga  3300
tctgagagc  ggaggtggt  atggacaga  atgagccca  gggagcaac  tgggctggc  3360
ctgtctgcc  catataaca  cagttggtg  tctgtgacc  cctgcatgg  ccagagccc  3420
atctaggat  ctgttccct  aggccctgg  ggatggtca  tgcctacca  acattcctc  3480
gtgtcctct  tgtgagtcc  gggctctca  accagaagt  gggtgaaag  tggggcaag  3540
ggcagtggg  ccgcttcta  tgtgagctc  tgacccact  gctgccctg  ctccccagt  3600
tgtgtgtga  agtgacagg  tgatcgtcg  tactgtttg  taataaaga  ttctgcttt  3660
ggcaaaaaa  aaaaaaaaa  3679



<210> 3919
<211> 949
<212> PRT
<213> Rattus norvegicus
<308> P52303
<400> 3919

Met Thr Asp Ser Lys Tyr Phe Thr Thr Thr Lys Lys Gly Glu Ile Phe 
  1               5                  10                  15
Glu Leu Lys Ala Glu Leu Asn Ser Asp Lys Lys Glu Lys Lys Lys Glu 
             20                  25                  30
Ala Val Lys Lys Val Ile Ala Ser Met Thr Val Gly Lys Asp Val Ser 
         35                  40                  45
Ala Leu Phe Pro Asp Val Val Asn Cys Met Gln Thr Asp Asn Leu Glu 
     50                  55                  60
Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
 65                  70                  75                  80
Pro Asp Met Ala Ile Met Ala Val Asn Thr Phe Val Lys Asp Cys Glu 
                 85                  90                  95
Asp Pro Asn Pro Leu Ile Arg Ala Leu Ala Val Arg Thr Met Gly Cys 
             100                105                110
Ile Arg Val Asp Lys Ile Thr Glu Tyr Leu Cys Glu Pro Leu Arg Lys 
         115                120                125
Cys Leu Lys Asp Glu Asp Pro Tyr Val Arg Lys Thr Ala Ala Val Cys 
     130                135                140
Val Ala Lys Leu His Asp Ile Asn Ala Gln Leu Val Glu Asp Gln Gly 
 145                150                155                160
Phe Leu Asp Thr Leu Lys Asp Leu Ile Ser Asp Ser Asn Pro Met Val 
                 165                170                175
Val Ala Asn Arg Val Ala Ala Leu Ser Glu Ile Ala Glu Ser His Pro 
             180                185                190
Ser Ser Asn Leu Leu Asp Leu Lys Ala Gln Ser Ile Asn Lys Leu Leu 
         195                200                205
Thr Ala Leu Asn Glu Cys Thr Glu Trp Ala Gln Ile Phe Ile Leu Asp 
     210                215                220
Cys Leu Gly Asn Tyr Met Pro Lys Asp Asp Arg Glu Ala Gln Ser Ile 
 225                230                235                240
Cys Glu Arg Val Thr Pro Arg Leu Ser His Ala Asn Ser Ala Val Val 
                 245                250                255
Leu Ser Ala Val Lys Val Leu Met Lys Phe Met Glu Met Leu Ser Lys 
             260                265                270
Asp Leu Asp Tyr Tyr Ala Thr Leu Leu Lys Lys Leu Ala Pro Pro Leu 
         275                280                285
Val Thr Leu Leu Ser Ala Glu Pro Glu Pro Gln Tyr Val Pro Leu Arg 
     290                295                300
Asn Ile Asn Leu Ile Val Gln Lys Arg Pro Glu Ile Leu Lys His Glu 
 305                310                315                320
Met Lys Val Phe Phe Val Lys Tyr Asn Asp Pro Ile Tyr Val Lys Leu 
                 325                330                335
Glu Lys Leu Asp Ile Met Ile Arg Leu Ala Ser Gln Ala Asn Ile Ala 
             340                345                350
Gln Val Leu Ala Glu Leu Lys Glu Tyr Ala Thr Glu Val Asp Val Asp 
         355                360                365
Phe Val Arg Lys Ala Val Arg Ala Ile Gly Arg Cys Ala Ile Lys Val 
     370                375                380
Glu Gln Ser Ala Glu Arg Cys Val Ser Thr Leu Leu Asp Leu Ile Gln 
 385                390                395                400
Thr Lys Val Asn Tyr Val Val Gln Glu Ala Ile Val Val Ile Lys Asp 
                 405                410                415
Ile Phe Arg Lys Tyr Pro Asn Lys Tyr Glu Ser Val Ile Ala Thr Leu 
             420                425                430
Cys Glu Asn Leu Asp Ser Leu Asp Glu Pro Glu Ala Arg Ala Ala Met 
         435                440                445
Ile Trp Ile Val Gly Glu Tyr Ala Glu Arg Ile Asp Asn Ala Asp Glu 
     450                455                460
Leu Leu Glu Ser Phe Leu Asp Gly Phe His Asp Glu Ser Thr Gln Val 
 465                470                475                480
Gln Leu Gln Leu Leu Thr Ala Ile Val Lys Leu Phe Leu Lys Lys Pro 
                 485                490                495
Thr Glu Thr Gln Glu Leu Val Gln Gln Val Leu Ser Leu Ala Thr Gln 
             500                505                510
Asp Ser Asp Asn Pro Asp Leu Arg Asp Arg Gly Tyr Ile Tyr Trp Arg 
         515                520                525
Leu Leu Ser Thr Asp Pro Val Ala Ala Lys Glu Val Val Leu Ala Glu 
     530                535                540
Lys Pro Leu Ile Ser Glu Glu Thr Asp Leu Ile Glu Pro Thr Leu Leu 
 545                550                555                560
Asp Glu Leu Ile Cys Tyr Ile Gly Thr Leu Ala Ser Val Tyr His Lys 
                 565                570                575
Pro Pro Asn Ala Phe Val Glu Gly Gly Arg Gly Val Val His Lys Ser 
             580                585                590
Leu Pro Pro Arg Thr Ala Ser Ser Glu Ser Thr Glu Ser Pro Glu Ala 
         595                600                605
Ala Pro Ala Gly Ala Pro Ala Ser Asp Gln Pro Asp Val Ile Pro Ala 
     610                615                620
Gln Gly Asp Leu Leu Gly Asp Leu Leu Asn Leu Asp Leu Gly Pro Pro 
 625                630                635                640
Val Ser Gly Pro Pro Leu Ala Ala Ser Ser Val Gln Met Gly Ala Val 
                 645                650                655
Asp Leu Leu Gly Gly Gly Leu Asp Ser Leu Met Gly Asp Glu Pro Glu 
             660                665                670
Gly Ile Gly Asp Ser Asn Phe Gly Ala Pro Pro Ala Ser Val Ala Ala 
         675                680                685
Ala Ala Pro Ala Arg Leu Gly Ala Pro Val Ser Ser Gly Leu Ser Asp 
     690                695                700
Leu Phe Asp Leu Thr Ser Gly Val Gly Thr Leu Ser Gly Ser Tyr Val 
 705                710                715                720
Ala Pro Lys Ala Val Trp Leu Pro Ala Met Lys Ala Lys Gly Leu Glu 
                 725                730                735
Ile Ser Gly Thr Phe Thr Arg Gln Val Gly Ser Ile Ser Met Asp Leu 
             740                745                750
Gln Leu Thr Asn Lys Ala Leu Gln Val Met Thr Asp Phe Ala Ile Gln 
         755                760                765
Phe Asn Arg Asn Ser Phe Gly Leu Ala Pro Ala Ala Pro Leu Gln Val 
     770                775                780
His Ala Pro Leu Ser Pro Asn Gln Thr Val Glu Ile Ser Leu Pro Leu 
 785                790                795                800
Asn Thr Val Gly Ser Val Met Lys Met Glu Pro Leu Asn Asn Leu Gln 
                 805                810                815
Val Ala Val Lys Asn Asn Ile Asp Val Phe Tyr Phe Ser Thr Leu Tyr 
             820                825                830
Pro Leu His Val Leu Phe Val Glu Asp Gly Lys Met Asp Arg Gln Met 
         835                840                845
Phe Leu Ala Thr Trp Lys Asp Ile Pro Asn Glu Asn Glu Ala Gln Phe 
     850                855                860
Gln Ile Arg Asp Cys Pro Leu Asn Thr Glu Ala Ala Ser Ser Lys Leu 
 865                870                875                880
Gln Ser Ser Asn Ile Phe Thr Val Ala Lys Arg Thr Val Glu Gly Gln 
                 885                890                895
Asp Met Leu Tyr Gln Ser Leu Lys Leu Thr Asn Gly Ile Trp Val Leu 
             900                905                910
Ala Glu Leu Arg Ile Gln Pro Gly Asn Pro Ser Phe Thr Leu Ser Leu 
         915                920                925
Lys Cys Arg Ala Pro Glu Val Ser Gln His Asp Ile Gln Ala Tyr Glu 
     930                935                940
Thr Ile Leu Lys Asn 
 945



<210> 3920
<211> 3859
<212> DNA
<213> Homo sapiens
<308> L13939
<400> 3920

gagctattg  gacctgcgg  agcctggct  cagataagg  accaaaatg  ctgactcaa  60
atatttcac  acgaccaag  aaggggaga  cttcgagct  aaggcagag  tcaacagtg  120
caagaagga  aagaagaag  aggcagtga  gaaagtgat  gcatcgatg  ccgtgggca  180
agatgtcag  gccctcttc  ccgatgtgg  caactgcat  cagacggac  acctggagc  240
gaagaagct  gtatacctc  acttgatga  ttacgccaa  agtcagcct  acatggcca  300
tatggccgt  aacaccttt  tgaaggact  tgaggaccc  aaccccctc  tccgagccc  360
ggcagtgcg  accatgggc  gcatccgcg  tgacaagat  acagagtac  tgtgcgagc  420
actccggaa  tgcctgaag  acgaggatc  atatgtgcg  aagacagca  ctgtgtgcg  480
ggccaagct  cacgacatc  acgcccagc  ggtggagga  cagggcttc  tggacaccc  540
taaagacct  atctccgac  ctaacccca  ggtggtggc  aatgcagtg  cagcgctct  600
agaaattgc  gagtctcac  ccagcagca  cctgctcga  ctgaaccca  agtccatca  660
caagctgct  acagccctc  atgagtgca  cgagtgggg  cagatcttc  tcctggact  720
cctcgccaa  tatatgccc  aggacgacc  cgaggccca  agcatctgt  agcgggtca  780
ccccaggct  tcccatgcc  actccgctg  ggtgctctc  gctgtgaag  tgctgatga  840
gttcatgga  atgttgtct  aggacttgg  ctactacgg  acactgctc  agaagctgg  900
cccacccct  gtcacactg  tgtcagccg  gccagagct  cagtatgtg  ccctgcgca  960
catcaatct  atcgtgcag  aaaggcctg  gatcctgaa  catgagatg  aggtgttct  1020
cgtgaagta  aacgaccct  tctacgtga  gctggagaa  ctggacatc  tgatccgcc  1080
ggcctctca  gccaacatc  cccaggtgt  ggcagagct  aaagagtac  caacagaag  1140
ggatgtgga  tttgtacgg  aggctgtgc  tgctattgg  cgctgcgcc  tcaaggtgg  1200
gcaatctgc  gagcgctgt  tgagcacgc  gctcgacct  atccagacc  aggtcaact  1260
tgtggtcca  gaggccatc  tggtcatca  ggacatctt  cgcaagtac  ccaacaagt  1320
tgagagtgt  attgccaca  tgtgtgaga  tctggactc  ctggatgag  ctgaggccc  1380
ggctgccat  atctggatt  tgggcgagt  cgcggaacg  atcgacaac  cagatgagc  1440
gctggagag  ttcctcgag  gcttccatg  cgagagcac  caggtccag  tgcagctgc  1500
gacagccat  gtgaaactc  ttctaaaga  gccaacaga  acccaggag  tggtgcagc  1560
ggtcctcag  ttggccact  aggactcag  taacccaga  ctgcgggac  gtggctaca  1620
ctactggcg  ctgctgtcc  cggacccgg  ggcagccaa  gaggtggtg  tggctgaga  1680
gccactcat  tctgaagag  cggacctca  cgagcccac  ctgttagac  agcttatct  1740
ctacatcgg  acgctggct  ccgtctacc  taagcctcc  agtgccttt  tggaggggg  1800
ccggggcgt  gtgcacaag  gcctgccac  tcgcacggc  tcgagtgag  gcgcagaga  1860
ccctgagac  gcccctact  gagcacctc  tggggagca  ccagatgtc  tccccgccc  1920
gggcgacct  ctgggtgac  tcctcaacc  ggacctcgg  cccccagtg  gcggcccac  1980
cctggccac  tcctcggtg  agatgggag  tgtggacct  cttggcggt  gccttgaca  2040
cctgatggg  gatgagcct  aagggattg  gggcaccaa  ttcgtggca  ctccaacag  2100
agcagtacc  gccaatctt  gagcaccca  cggcagtgg  ctgagtgac  tctttgacc  2160
gaccagtgg  gtgggcacc  tgtcaggat  atatgtggc  cccaaagca  tctggctcc  2220
agccatgaa  gctaagggg  tggagatct  aggcacctt  acccgccag  tgggctcca  2280
ctccatgga  ctgcagctg  ccaacaagg  cttgcaggt  atgaccgac  ttgccatcc  2340
gttcaaccg  aacagcttt  gcctggccc  cgccgcccc  ctccaggtc  acgcgccac  2400
cagccccaa  cagacagtg  agatctccc  gcctctcag  acggtgggc  cggtcatga  2460
gatggagcc  ctgaacaac  tccaggtgg  cgtgaagaa  aacatcgat  tcttctact  2520
cagcacctt  tacccactg  acatcctct  tgtggagga  gggaagatg  accggcaga  2580
gttcctggc  acatggaag  atattccca  tgagaatga  gcccagttc  agatcagag  2640
ctgccccct  aatgcagag  ctgcgagca  caagctgca  agcagcaac  tcttcactg  2700
cgccaagag  aacgtggag  gccaggaca  gctctacca  tccctgaag  tgaccaacg  2760
catctgggt  ctggcggag  tgcggatcc  gccgggcaa  cccagctgc  cggacttag  2820
gctgtccct  aagtgtcga  caccagagg  gtcccagca  gtgtaccag  cctacgaga  2880
catcctcaa  aactgagac  ccggccagc  cccacccca  ccttctgcc  gccccatcg  2940
ggaggcccc  cgggggcag  acatcttcc  cctcgcagg  gggaccagg  ggggctcca  3000
gccactcag  gggctccct  gtcctgatg  cagaaccca  ccgatccct  gggtagggc  3060
ccaccccct  ctggggtga  agcgcagtg  actcccgtg  tctgggaca  ccctgctcc  3120
gtggctgtg  tgtggggtt  agtgaggtg  ggaccaaag  aaacagagc  agagcagcc  3180
cagaagctg  gcctgaagg  tgagtgtgg  gcttgcccc  ccggctcac  gccccggca  3240
cccctggct  cttggtctc  ccggttggt  ttaaagggc  ctccactgc  acctctcat  3300
ggatggacc  tgccaacct  gcctgggtg  gcagggagg  gttcccctt  gtaccagga  3360
agctgctca  ttagggcct  gggctcaag  agctgtagg  gccggcaga  gggcagagc  3420
aggctggga  gagcccagg  cctgcacca  ccacttgca  ccaccaggc  ggtgccctg  3480
agctgtgcc  gttgggcca  agcctcccg  gtgctgacc  acatggtca  gaccaggca  3540
aagctccca  agcccctgt  tcgggctcc  caccgactg  cagctgcac  atccccaac  3600
ccccacttc  gccccaagg  tggtcactg  ctgtgatac  ttcctcagt  tcgcctctg  3660
gcccaggcc  cctgccaca  agactgggc  gagagatgg  gctgggtaa  cgggtgcgc  3720
tcctgtttg  gtttcttcg  ggtttctct  tagtgtctg  tgccctcct  ctggcctcc  3780
aggtttcag  tgtgtctga  agagcatta  gttttcctg  tactgctgt  taataataa  3840
gaaagattc  gcttttggc  3859



<210> 3921
<211> 949
<212> PRT
<213> Homo sapiens
<308> Q10567
<400> 3921

Met Thr Asp Ser Lys Tyr Phe Thr Thr Thr Lys Lys Gly Glu Ile Phe 
  1               5                  10                  15
Glu Leu Lys Ala Glu Leu Asn Ser Asp Lys Lys Glu Lys Lys Lys Glu 
             20                  25                  30
Ala Val Lys Lys Val Ile Ala Ser Met Thr Val Gly Lys Asp Val Ser 
         35                  40                  45
Ala Leu Phe Pro Asp Val Val Asn Cys Met Gln Thr Asp Asn Leu Glu 
     50                  55                  60
Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
 65                  70                  75                  80
Pro Asp Met Ala Ile Met Ala Val Asn Thr Phe Val Lys Asp Cys Glu 
                 85                  90                  95
Asp Pro Asn Pro Leu Ile Arg Ala Leu Ala Val Arg Thr Met Gly Cys 
             100                105                110
Ile Arg Val Asp Lys Ile Thr Glu Tyr Leu Cys Glu Pro Leu Arg Lys 
         115                120                125
Cys Leu Lys Asp Glu Asp Pro Tyr Val Arg Lys Thr Ala Ala Val Cys 
     130                135                140
Val Ala Lys Leu His Asp Ile Asn Ala Gln Leu Val Glu Asp Gln Gly 
 145                150                155                160
Phe Leu Asp Thr Leu Lys Asp Leu Ile Ser Asp Ser Asn Pro Met Val 
                 165                170                175
Val Ala Asn Ala Val Ala Ala Leu Ser Glu Ile Ala Glu Ser His Pro 
             180                185                190
Ser Ser Asn Leu Leu Asp Leu Asn Pro Gln Ser Ile Asn Lys Leu Leu 
         195                200                205
Thr Ala Leu Asn Glu Cys Thr Glu Trp Gly Gln Ile Phe Ile Leu Asp 
     210                215                220
Cys Leu Ala Asn Tyr Met Pro Lys Asp Asp Arg Glu Ala Gln Ser Ile 
 225                230                235                240
Cys Glu Arg Val Thr Pro Arg Leu Ser His Ala Asn Ser Ala Val Val 
                 245                250                255
Leu Ser Ala Val Lys Val Leu Met Lys Phe Met Glu Met Leu Ser Lys 
             260                265                270
Asp Leu Asp Tyr Tyr Gly Thr Leu Leu Lys Lys Leu Ala Pro Pro Leu 
         275                280                285
Val Thr Leu Leu Ser Ala Glu Pro Glu Leu Gln Tyr Val Ala Leu Arg 
     290                295                300
Asn Ile Asn Leu Ile Val Gln Lys Arg Pro Glu Ile Leu Lys His Glu 
 305                310                315                320
Met Lys Val Phe Phe Val Lys Tyr Asn Asp Pro Ile Tyr Val Lys Leu 
                 325                330                335
Glu Lys Leu Asp Ile Met Ile Arg Leu Ala Ser Gln Ala Asn Ile Ala 
             340                345                350
Gln Val Leu Ala Glu Leu Lys Glu Tyr Ala Thr Glu Val Asp Val Asp 
         355                360                365
Phe Val Arg Lys Ala Val Arg Ala Ile Gly Arg Cys Ala Ile Lys Val 
     370                375                380
Glu Gln Ser Ala Glu Arg Cys Val Ser Thr Leu Leu Asp Leu Ile Gln 
 385                390                395                400
Thr Lys Val Asn Tyr Val Val Gln Glu Ala Ile Val Val Ile Lys Asp 
                 405                410                415
Ile Phe Arg Lys Tyr Pro Asn Lys Tyr Glu Ser Val Ile Ala Thr Leu 
             420                425                430
Cys Glu Asn Leu Asp Ser Leu Asp Glu Pro Glu Ala Arg Ala Ala Met 
         435                440                445
Ile Trp Ile Val Gly Glu Tyr Ala Glu Arg Ile Asp Asn Ala Asp Glu 
     450                455                460
Leu Leu Glu Ser Phe Leu Glu Gly Phe His Asp Glu Ser Thr Gln Val 
 465                470                475                480
Gln Leu Gln Leu Leu Thr Ala Ile Val Lys Leu Phe Leu Lys Lys Pro 
                 485                490                495
Thr Glu Thr Gln Glu Leu Val Gln Gln Val Leu Ser Leu Ala Thr Gln 
             500                505                510
Asp Ser Asp Asn Pro Asp Leu Arg Asp Arg Gly Tyr Ile Tyr Trp Arg 
         515                520                525
Leu Leu Ser Thr Asp Pro Val Ala Ala Lys Glu Val Val Leu Ala Glu 
     530                535                540
Lys Pro Leu Ile Ser Glu Glu Thr Asp Leu Ile Glu Pro Thr Leu Leu 
 545                550                555                560
Asp Glu Leu Ile Cys Tyr Ile Gly Thr Leu Ala Ser Val Tyr His Lys 
                 565                570                575
Pro Pro Ser Ala Phe Val Glu Gly Gly Arg Gly Val Val His Lys Ser 
             580                585                590
Leu Pro Pro Arg Thr Ala Ser Ser Glu Ser Ala Glu Ser Pro Glu Thr 
         595                600                605
Ala Pro Thr Gly Ala Pro Pro Gly Glu Gln Pro Asp Val Ile Pro Ala 
     610                615                620
Gln Gly Asp Leu Leu Gly Asp Leu Leu Asn Leu Asp Leu Gly Pro Pro 
 625                630                635                640
Val Ser Gly Pro Pro Leu Ala Thr Ser Ser Val Gln Met Gly Ala Val 
                 645                650                655
Asp Leu Leu Gly Gly Gly Leu Asp Ser Leu Met Gly Asp Glu Pro Glu 
             660                665                670
Gly Ile Gly Gly Thr Asn Phe Val Ala Pro Pro Thr Ala Ala Val Pro 
         675                680                685
Ala Asn Leu Gly Ala Pro Ile Gly Ser Gly Leu Ser Asp Leu Phe Asp 
     690                695                700
Leu Thr Ser Gly Val Gly Thr Leu Ser Gly Ser Tyr Val Ala Pro Lys 
 705                710                715                720
Ala Val Trp Leu Pro Ala Met Lys Ala Lys Gly Leu Glu Ile Ser Gly 
                 725                730                735
Thr Phe Thr Arg Gln Val Gly Ser Ile Ser Met Asp Leu Gln Leu Thr 
             740                745                750
Asn Lys Ala Leu Gln Val Met Thr Asp Phe Ala Ile Gln Phe Asn Arg 
         755                760                765
Asn Ser Phe Gly Leu Ala Pro Ala Ala Pro Leu Gln Val His Ala Pro 
     770                775                780
Leu Ser Pro Asn Gln Thr Val Glu Ile Ser Leu Pro Leu Ser Thr Val 
 785                790                795                800
Gly Ser Val Met Lys Met Glu Pro Leu Asn Asn Leu Gln Val Ala Val 
                 805                810                815
Lys Asn Asn Ile Asp Val Phe Tyr Phe Ser Thr Leu Tyr Pro Leu His 
             820                825                830
Ile Leu Phe Val Glu Asp Gly Lys Met Asp Arg Gln Met Phe Leu Ala 
         835                840                845
Thr Trp Lys Asp Ile Pro Asn Glu Asn Glu Ala Gln Phe Gln Ile Arg 
     850                855                860
Asp Cys Pro Leu Asn Ala Glu Ala Ala Ser Ser Lys Leu Gln Ser Ser 
 865                870                875                880
Asn Ile Phe Thr Val Ala Lys Arg Asn Val Glu Gly Gln Asp Met Leu 
                 885                890                895
Tyr Gln Ser Leu Lys Leu Thr Asn Gly Ile Trp Val Leu Ala Glu Leu 
             900                905                910
Arg Ile Gln Pro Gly Asn Pro Ser Cys Thr Asp Leu Glu Leu Ser Leu 
         915                920                925
Lys Cys Arg Ala Pro Glu Val Ser Gln His Val Tyr Gln Ala Tyr Glu 
     930                935                940
Thr Ile Leu Lys Asn 
 945



<210> 3922
<211> 1386
<212> DNA
<213> Rattus norvegicus
<308> M77694
<400> 3922

ctgctgccc  gtgctcttc  gcatgtcct  tattccggt  gccgaggac  ccgactttc  60
catccaaaa  ctgccctat  gcgttttct  cactcaaag  aacccaaag  cacggattg  120
tgtggccat  ggtgaccag  tcttggacc  gagtgtcat  aaacacctc  ttaccggac  180
tgtcctctc  aaacatcag  atgtcttcg  tgagacaac  ctcaatagc  ttatgggcc  240
cggccaagc  gcatggaag  aggcaagag  atctttaca  aacttactg  ctgccagcc  300
agcccagct  agagatgac  aggagcttc  gcagcgtgc  ttcacctcc  aggcttctg  360
cacgatgca  cttcctgct  ccataggag  ctacacgga  ttctactcc  ctctgcagc  420
tgccactaa  gttggcatt  tgttcaggg  caaggagaa  gcgctgttg  ccaattggc  480
ccacttacc  gtgggatac  atggccgag  ttcctccgt  gtggtgtct  gtaccccaa  540
tcgaagacc  atgggacag  tgagacctg  taactcaaa  cctcctgtg  acggtgcca  600
caaacgctt  gacatggag  tggaaatgg  tttctttgt  ggccctggg  acagattcg  660
cgagccaat  cccatttcc  aggcccagg  gcacatttt  gggatggtc  tcatgaacg  720
ctggagtgc  cgagacatc  agcaatggg  gtacgtccc  cttgggcca  tcctgggga  780
aagttttgg  accaccatc  ccccatggg  ggtgcccat  gatgctctc  tgccctttg  840
ggtgccaaa  ccaaagcag  accctaagc  cctgccata  ctctgccac  gccagccct  900
cacatttga  atcaacctg  ccgttgctt  gaaaggaga  ggaatgagc  aggcagcta  960
catctgcag  tccaacttt  agcacatgt  ctggaccat  ctgcagcaa  tgacacacc  1020
ctctgttaa  ggatgcaat  tgagacctg  ggacctctt  gcttctgga  ccatcagtg  1080
atcagaccc  gaaagcttt  gctccatgc  ggaactgtc  tggaaggga  caaaggcta  1140
cgatgtggg  caggggcaa  ccaggacct  tcttctgga  ggagatgaa  tcatcataa  1200
aggtcactg  cagggggat  gctaccgtg  tggttttgg  caatgtgct  ggaaagtgc  1260
gcctgccct  tcgccagcc  gaagctcca  aatccacag  acacagcct  gccttgtga  1320
gatcatact  caactgcat  agtcaggaa  gaataaagc  attttgatt  gggaaaaaa  1380
aaaaaa  1386



<210> 3923
<211> 419
<212> PRT
<213> Rattus norvegicus
<308> P25093
<400> 3923

Met Ser Phe Ile Pro Val Ala Glu Asp Ser Asp Phe Pro Ile Gln Asn 
  1               5                  10                  15
Leu Pro Tyr Gly Val Phe Ser Thr Gln Ser Asn Pro Lys Pro Arg Ile 
             20                  25                  30
Gly Val Ala Ile Gly Asp Gln Ile Leu Asp Leu Ser Val Ile Lys His 
         35                  40                  45
Leu Phe Thr Gly Pro Val Leu Ser Lys His Gln His Val Phe Asp Glu 
     50                  55                  60
Thr Thr Leu Asn Ser Phe Met Gly Leu Gly Gln Ala Ala Trp Lys Glu 
 65                  70                  75                  80
Ala Arg Ala Ser Leu Gln Asn Leu Leu Ser Ala Ser Gln Ala Gln Leu 
                 85                  90                  95
Arg Asp Asp Lys Glu Leu Arg Gln Arg Ala Phe Thr Ser Gln Ala Ser 
             100                105                110
Ala Thr Met His Leu Pro Ala Thr Ile Gly Asp Tyr Thr Asp Phe Tyr 
         115                120                125
Ser Ser Leu Gln His Ala Thr Asn Val Gly Ile Met Phe Arg Gly Lys 
     130                135                140
Glu Asn Ala Leu Leu Pro Asn Trp Leu His Leu Pro Val Gly Tyr His 
 145                150                155                160
Gly Arg Ala Ser Ser Val Val Val Ser Gly Thr Pro Ile Arg Arg Pro 
                 165                170                175
Met Gly Gln Met Arg Pro Asp Asn Ser Lys Pro Pro Val Tyr Gly Ala 
             180                185                190
Ser Lys Arg Leu Asp Met Glu Leu Glu Met Ala Phe Phe Val Gly Pro 
         195                200                205
Gly Asn Arg Phe Gly Glu Pro Ile Pro Ile Ser Lys Ala Gln Glu His 
     210                215                220
Ile Phe Gly Met Val Leu Met Asn Asp Trp Ser Ala Arg Asp Ile Gln 
 225                230                235                240
Gln Trp Glu Tyr Val Pro Leu Gly Pro Phe Leu Gly Lys Ser Phe Gly 
                 245                250                255
Thr Thr Ile Ser Pro Trp Val Val Pro Met Asp Ala Leu Met Pro Phe 
             260                265                270
Val Val Pro Asn Pro Lys Gln Asp Pro Lys Pro Leu Pro Tyr Leu Cys 
         275                280                285
His Ser Gln Pro Tyr Thr Phe Asp Ile Asn Leu Ser Val Ala Leu Lys 
     290                295                300
Gly Glu Gly Met Ser Gln Ala Ala Thr Ile Cys Arg Ser Asn Phe Lys 
 305                310                315                320
His Met Tyr Trp Thr Ile Leu Gln Gln Leu Thr His His Ser Val Asn 
                 325                330                335
Gly Cys Asn Leu Arg Pro Gly Asp Leu Leu Ala Ser Gly Thr Ile Ser 
             340                345                350
Gly Ser Asp Pro Glu Ser Phe Gly Ser Met Leu Glu Leu Ser Trp Lys 
         355                360                365
Gly Thr Lys Ala Ile Asp Val Gly Gln Gly Gln Thr Arg Thr Phe Leu 
     370                375                380
Leu Asp Gly Asp Glu Val Ile Ile Thr Gly His Cys Gln Gly Asp Gly 
 385                390                395                400
Tyr Arg Val Gly Phe Gly Gln Cys Ala Gly Lys Val Leu Pro Ala Leu 
                 405                410                415
Ser Pro Ala 
             420



<210> 3924
<211> 1310
<212> DNA
<213> Homo sapiens
<308> X51728
<400> 3924

cctcctagc  aagaccgag  ataggtgtg  ccattggcg  ccagatcct  gacctcagc  60
tcatcaagc  cctctttac  ggtcctgtc  tctccaaac  ccaggatgt  ttcaatcag  120
ctacactca  cagcttcat  ggcctgggt  aggctgcct  gaaggaggc  agagtgttc  180
tgcagaact  gctgtctgt  agccaagcc  ggctcagag  tgacaccga  cttcggaag  240
gtgcattca  ctcccaggc  tctgccacg  tgcaccttc  agccaccat  ggagactac  300
cagacttct  ttcctctcg  cagcatgct  ccaacgtcg  aatcatgtt  agggacaag  360
agaatgcgt  gatgccaaa  tggctgcac  taccagtgg  ctaccatgg  cgtgcctcc  420
ctgtcgtgg  gtctggcac  ccaatccga  ggcccatgg  acagatgaa  cctgatgac  480
ctaagcctc  cgtatatgg  gcctgcaag  tcttggaca  ggagctgga  atggctttt  540
ttgtaggcc  tggaaacag  ttgggagag  cgatcccca  ttccaaggc  catgagcac  600
tttttggaa  ggtccttat  aacgactgg  gtgcacgag  cattcagaa  tgggagtat  660
tccctctcg  gccattcct  gggaagagt  ttgggacca  tgtctctcc  tgggtggtg  720
ccatggatg  tctcatgcc  tttgctgtg  ccaacccga  gcaggaccc  aggcccctg  780
cgtatctgt  ccatgacga  ccctacaca  ttgacatca  cctctctgt  aacctgaaa  840
gagaaggaa  gagccaggc  gctaccata  gcaagtcca  ttttaagta  atgtactgg  900
cgatgctgc  gcagctcac  caccactct  tcaacggct  caacctgcg  ccgggggac  960
tcctggctt  tgggaccat  agcgggccg  agccagaaa  cttcggctc  atgttggaa  1020
tgtcgtgga  gggaacgaa  cccatagac  tggggaatg  tcagaccag  aagtttctg  1080
tggacgggg  tgaagtcat  ataacaggg  actgccagg  ggatggtta  cgcatcggc  1140
ttggccagt  tgctggaaa  gtgctgcct  ctctcctgc  atcatgaga  tttctctgc  1200
cttctggaa  caaagggct  aagcacccc  ttcaaccct  tgactgggg  cctccctcg  1260
gctgtaggc  tggtccgct  ttcagtgac  aataaagcc  ttgtgctctg  1310



<210> 3925
<211> 419
<212> PRT
<213> Homo sapiens
<308> P16930
<400> 3925

Met Ser Phe Ile Pro Val Ala Glu Asp Ser Asp Phe Pro Ile His Asn 
  1               5                  10                  15
Leu Pro Tyr Gly Val Phe Ser Thr Arg Gly Asp Pro Arg Pro Arg Ile 
             20                  25                  30
Gly Val Ala Ile Gly Asp Gln Ile Leu Asp Leu Ser Ile Ile Lys His 
         35                  40                  45
Leu Phe Thr Gly Pro Val Leu Ser Lys His Gln Asp Val Phe Asn Gln 
     50                  55                  60
Pro Thr Leu Asn Ser Phe Met Gly Leu Gly Gln Ala Ala Trp Lys Glu 
 65                  70                  75                  80
Ala Arg Val Phe Leu Gln Asn Leu Leu Ser Val Ser Gln Ala Arg Leu 
                 85                  90                  95
Arg Asp Asp Thr Glu Leu Arg Lys Cys Ala Phe Ile Ser Gln Ala Ser 
             100                105                110
Ala Thr Met His Leu Pro Ala Thr Ile Gly Asp Tyr Thr Asp Phe Tyr 
         115                120                125
Ser Ser Arg Gln His Ala Thr Asn Val Gly Ile Met Phe Arg Asp Lys 
     130                135                140
Glu Asn Ala Leu Met Pro Asn Trp Leu His Leu Pro Val Gly Tyr His 
 145                150                155                160
Gly Arg Ala Ser Ser Val Val Val Ser Gly Thr Pro Ile Arg Arg Pro 
                 165                170                175
Met Gly Gln Met Lys Pro Asp Asp Ser Lys Pro Pro Val Tyr Gly Ala 
             180                185                190
Cys Lys Leu Leu Asp Met Glu Leu Glu Met Ala Phe Phe Val Gly Pro 
         195                200                205
Gly Asn Arg Leu Gly Glu Pro Ile Pro Ile Ser Lys Ala His Glu His 
     210                215                220
Ile Phe Gly Met Val Leu Met Asn Asp Trp Ser Ala Arg Asp Ile Gln 
 225                230                235                240
Lys Trp Glu Tyr Val Pro Leu Gly Pro Phe Leu Gly Lys Ser Phe Gly 
                 245                250                255
Thr Thr Val Ser Pro Trp Val Val Pro Met Asp Ala Leu Met Pro Phe 
             260                265                270
Ala Val Pro Asn Pro Lys Gln Asp Pro Arg Pro Leu Pro Tyr Leu Cys 
         275                280                285
His Asp Glu Pro Tyr Thr Phe Asp Ile Asn Leu Ser Val Asn Leu Lys 
     290                295                300
Gly Glu Gly Met Ser Gln Ala Ala Thr Ile Cys Lys Ser Asn Phe Lys 
 305                310                315                320
Tyr Met Tyr Trp Thr Met Leu Gln Gln Leu Thr His His Ser Val Asn 
                 325                330                335
Gly Cys Asn Leu Arg Pro Gly Asp Leu Leu Ala Ser Gly Thr Ile Ser 
             340                345                350
Gly Pro Glu Pro Glu Asn Phe Gly Ser Met Leu Glu Leu Ser Trp Lys 
         355                360                365
Gly Thr Lys Pro Ile Asp Leu Gly Asn Gly Gln Thr Arg Lys Phe Leu 
     370                375                380
Leu Asp Gly Asp Glu Val Ile Ile Thr Gly Tyr Cys Gln Gly Asp Gly 
 385                390                395                400
Tyr Arg Ile Gly Phe Gly Gln Cys Ala Gly Lys Val Leu Pro Ala Leu 
                 405                410                415
Leu Pro Ser 
             420



<210> 3926
<211> 2396
<212> DNA
<213> Rattus norvegicus
<308> M80367
<400> 3926

ttaaaagat  taactcttc  caagttctc  ggagacaat  tggaacttc  taggttatg  60
cagggtctt  gccacagag  ccgtgaaaa  ggacagagt  atcagcagc  tgaccctga  120
cctgtcagg  attcttctc  aaagaattt  gtttaagag  caaaagagc  ccatggaca  180
ggcctcgga  atccacatg  tacaaccca  gtgcctcat  gagaacact  aggctcacc  240
agtgatcaa  caggaggct  tgaggattt  gtctgccat  aaccagcct  tggtggtgg  300
ggcaatcgt  ggcctctac  gcacaggca  atcctacct  atgaacaaa  tggctggga  360
gagaacagg  ttctccctg  gctccactg  gcagtctca  accaagggc  tctggatgt  420
gtgtgtgcc  caccccaag  aggcagggc  aaccctagt  ctgcttgac  ccgagggcc  480
tgaagatgt  gagaaggga  acaaccaga  cgactgctg  atctttgcc  tggcagtcc  540
cctcagcag  accttcgtc  acaacagca  gggaaccat  aaccagcag  ccatggacc  600
gctgcatta  gtgacagag  tgactgatc  tatcaagtc  aagtcatca  ctgatcaga  660
tgggataga  gactctgct  actttgtgg  cttctttcc  acctttgtg  gggctctga  720
agatttctc  ctggagttg  aagtcaatg  aaaacttgt  actcctgat  agtacctgg  780
gcattcgct  accctgaag  aaggagctg  taagaaaac  aaaagcttt  atgagcctc  840
actgtgcat  aggaaattc  ttccgaaga  gaagtgttt  atctttgac  gacctgctc  900
gaggaagca  ctctgcaaa  tggagactc  gggggagga  gagctgtgt  gtgagtttg  960
agaacaagt  gcagaattc  cctcgtata  cttcagtta  tctgctgtc  aaactctgt  1020
tggtggcat  atagtcaat  ggccacgtc  aaagagcct  gtgcagacc  atgttggtg  1080
catcagcag  gggtctctc  cctgcatgg  gagtgcagt  ctgactttg  cccagatag  1140
gaactcagc  gcagtacaa  aggccatca  ccactatga  gaacagatg  atcagaaaa  1200
ccagatgcc  acagaaacc  tccaggagc  gctagacct  cacaggctg  ttgagaggg  1260
ggccattga  atcttccta  agaattctt  caaggatgt  gaccagaag  tccagacag  1320
attagggaa  ctgctgata  caaagcgag  tgcctttat  aagaagaac  cggatgtat  1380
atcagctca  tgttcagat  tgatagagg  tatttttgg  cctctggaa  aagaagtaa  1440
acaagggac  ttttccaaa  caggaggtt  cttcctctt  cttcagatg  gacaagagc  1500
agagaagaa  tataaccag  ctcctggga  ggggctcga  gcagaagcg  tgctgaaaa  1560
gtactttga  tccaaggaa  acattgttg  aacacttct  aagacggat  agtcactca  1620
ggaggcagc  aaggagatt  aagtggaac  gattaaggc  gaaactgct  aagctgcaa  1680
cagagagtt  gcagagaag  aggagaagt  tgagctgat  atgcagcag  aggaagaga  1740
ttaccagga  cacgtgaga  agctgactg  gaagatgaa  gaggaacag  aaaagttaa  1800
agaagaaca  gacaacatc  tagctctta  acttcggga  caggaaaaa  ttctcaggg  1860
aggatacga  aacgagagc  agaaacttc  tcgagagat  gagaacatg  agagacgac  1920
atcacctgg  aaatgcacc  tactctaaa  gtccgaggc  caaacctct  tgccaaact  1980
ttcatcaca  aatatgtgg  ctgacacct  taggctttg  aacagctgt  atgatacta  2040
gttcatttt  gctcaaaaa  caatcacat  caaatccag  ttggggtca  cgtctgacc  2100
ctgggcagc  tcagaagaa  ttcgcccag  cacatatgt  cctcctcta  aatcttaag  2160
tttcctctt  cctacagta  aacttctgc  attacagag  aggcaactt  taattaact  2220
acaaaacaa  ctccctttc  ctgaggacc  tgacatttt  ctacagtcc  tcaaaacct  2280
aatcccatc  ccattttcc  tgtgatctt  ctccctact  tggcagtgt  tcttgaact  2340
tctcaggac  aatgtcttg  aagagcacg  gttaataaa  ttgattagc  taccat  2396



<210> 3927
<211> 591
<212> PRT
<213> Rattus norvegicus
<308> AAA19909
<400> 3927

Met Asp Met Ala Ser Glu Ile His Met Leu Gln Pro Met Cys Leu Ile 
  1               5                  10                  15
Glu Asn Thr Glu Ala His Leu Val Ile Asn Gln Glu Ala Leu Arg Ile 
             20                  25                  30
Leu Ser Ala Ile Asn Gln Pro Val Val Val Val Ala Ile Val Gly Leu 
         35                  40                  45
Tyr Arg Thr Gly Lys Ser Tyr Leu Met Asn Lys Leu Ala Gly Lys Arg 
     50                  55                  60
Thr Gly Phe Ser Leu Gly Ser Thr Val Gln Ser His Thr Lys Gly Ile 
 65                  70                  75                  80
Trp Met Trp Cys Val Pro His Pro Lys Lys Ala Gly Gln Thr Leu Val 
                 85                  90                  95
Leu Leu Asp Thr Glu Gly Leu Glu Asp Val Glu Lys Gly Asp Asn Gln 
             100                105                110
Asn Asp Cys Trp Ile Phe Ala Leu Ala Val Leu Leu Ser Ser Thr Phe 
         115                120                125
Val Tyr Asn Ser Met Gly Thr Ile Asn Gln Gln Ala Met Asp Gln Leu 
     130                135                140
His Tyr Val Thr Glu Leu Thr Asp Leu Ile Lys Ser Lys Ser Ser Pro 
 145                150                155                160
Asp Gln Ser Gly Ile Asp Asp Ser Ala Asn Phe Val Gly Phe Phe Pro 
                 165                170                175
Thr Phe Val Trp Ala Leu Arg Asp Phe Ser Leu Glu Leu Glu Val Asn 
             180                185                190
Gly Lys Leu Val Thr Pro Asp Glu Tyr Leu Glu His Ser Leu Thr Leu 
         195                200                205
Lys Lys Gly Ala Asp Lys Lys Thr Lys Ser Phe Asn Glu Pro Arg Leu 
     210                215                220
Cys Ile Arg Lys Phe Phe Pro Lys Arg Lys Cys Phe Ile Phe Asp Arg 
 225                230                235                240
Pro Ala Leu Arg Lys Gln Leu Cys Lys Leu Glu Thr Leu Gly Glu Glu 
                 245                250                255
Glu Leu Cys Ser Glu Phe Val Glu Gln Val Ala Glu Phe Thr Ser Tyr 
             260                265                270
Ile Phe Ser Tyr Ser Ala Val Lys Thr Leu Ser Gly Gly Ile Ile Val 
         275                280                285
Asn Gly Pro Arg Leu Lys Ser Leu Val Gln Thr Tyr Val Gly Ala Ile 
     290                295                300
Ser Ser Gly Ser Leu Pro Cys Met Glu Ser Ala Val Leu Thr Leu Ala 
 305                310                315                320
Gln Ile Glu Asn Ser Ala Ala Val Gln Lys Ala Ile Thr His Tyr Glu 
                 325                330                335
Glu Gln Met Asn Gln Lys Ile Gln Met Pro Thr Glu Thr Leu Gln Glu 
             340                345                350
Leu Leu Asp Leu His Arg Leu Ile Glu Arg Glu Ala Ile Glu Ile Phe 
         355                360                365
Leu Lys Asn Ser Phe Lys Asp Val Asp Gln Lys Phe Gln Thr Glu Leu 
     370                375                380
Gly Asn Leu Leu Ile Ser Lys Arg Asp Ala Phe Ile Lys Lys Asn Ser 
 385                390                395                400
Asp Val Ser Ser Ala His Cys Ser Asp Leu Ile Glu Asp Ile Phe Gly 
                 405                410                415
Pro Leu Glu Glu Glu Val Lys Gln Gly Thr Phe Ser Lys Pro Gly Gly 
             420                425                430
Tyr Phe Leu Phe Leu Gln Met Arg Gln Glu Leu Glu Lys Lys Tyr Asn 
         435                440                445
Gln Ala Pro Gly Lys Gly Leu Glu Ala Glu Ala Val Leu Lys Lys Tyr 
     450                455                460
Phe Glu Ser Lys Glu Asp Ile Val Glu Thr Leu Leu Lys Thr Asp Gln 
 465                470                475                480
Ser Leu Thr Glu Ala Ala Lys Glu Ile Glu Val Glu Arg Ile Lys Ala 
                 485                490                495
Glu Thr Ala Glu Ala Ala Asn Arg Glu Leu Ala Glu Lys Gln Glu Lys 
             500                505                510
Phe Glu Leu Met Met Gln Gln Lys Glu Glu Ser Tyr Gln Glu His Val 
         515                520                525
Arg Gln Leu Thr Glu Lys Met Lys Glu Glu Gln Lys Lys Leu Ile Glu 
     530                535                540
Glu Gln Asp Asn Ile Ile Ala Leu Lys Leu Arg Glu Gln Glu Lys Phe 
 545                550                555                560
Leu Arg Glu Gly Tyr Glu Asn Glu Ser Lys Lys Leu Leu Arg Glu Ile 
                 565                570                575
Glu Asn Met Lys Arg Arg Gln Ser Pro Gly Lys Cys Thr Ile Leu 
             580                585                590



<210> 3928
<211> 2881
<212> DNA
<213> Homo sapiens
<308> M55542
<400> 3928

acagaagtg  tagaagcca  tgctcgtga  ctaaggaga  aaagaacag  caagggaac  60
gcctggaca  ggcatcaga  atccacatg  caggcccaa  gtgcctcat  gagaacact  120
atgggcgac  gatggcgaa  ccagaagct  tgaagatcc  ttctgccat  acacagcct  180
tggtggtgg  ggcaattgt  ggcctctac  gcacaggca  atcctacct  atgaacaag  240
tggctggaa  gaaaaaggg  ttctctctg  gctccacgg  gcagtctca  actaaagga  300
tctggatgt  gtgtgtgcc  caccccaag  agccaggcc  catcctagt  ctgctggac  360
ccgagggtc  gggagatgt  gagaagggt  acaaccaga  tgactcctg  atcttcgcc  420
tggccgtcc  cctgagcag  accttcgtg  acaatagca  aggaaccat  aaccagcag  480
ctatggacc  actgtacta  gtgacagag  tgacacata  aatccgatc  aaatcctca  540
ctgatgaga  tgagaatga  gttgaggat  cagctgact  tgtgagctt  ttcccagac  600
ttgtgtgga  actgagaga  ttctccctg  acttggaag  agatggaca  cccctcaca  660
cagatgagt  cctgacata  tccctgaag  tgaagaaag  taccagtca  aaagatgaa  720
cttttaacc  gcccagact  tgtatccgg  aattcttcc  aaagaaaaa  tgctttgtc  780
ttgatcggc  cgttcaccg  aggaagctt  cccagctcg  gaaactaca  gatgaagag  840
tggaccccg  atttgtgca  caagtagca  acttctgtt  ctacatctt  agtaattcc  900
aaactaaaa  tctttcagg  ggcatccag  tcaacgggc  tcgtctaga  agcctggtg  960
tgacctacg  caatgccat  agcagtggg  atctgccgt  catggagaa  gcagtcctg  1020
ccttggccc  gatagagaa  tcagctgca  tgcaaaagg  tattgccca  tatgaacag  1080
agatgggcc  gaaggtgca  ctgcccaca  aaagcctcc  ggagctgct  gacctgcac  1140
gggacagtg  gagagaggc  attgaagtc  tcatcagga  ttccttcaa  gatgtggac  1200
atctatttc  aaaggagtt  gcggcccag  tagaaaaaa  gcgggatga  ttttgtaaa  1260
agaatcagg  agcatcatc  gatcgttgc  caggtttac  tcaggtcat  ttcagtcct  1320
tagaagaag  agtgaaggc  ggaatttat  cgaaaccag  gggctatcg  ctctttgtt  1380
agaagctac  agacctgaa  aaaaagtac  atgaggaac  gaggaaggg  atacaggct  1440
aagagattc  gcagacata  ttgaaatcc  aggagtcta  gactgatgc  attctccag  1500
cagaccaga  tctcacaga  aaagaaaag  agattgaag  ggaacgtgt  aaagctgag  1560
ctgcacagg  ttcagcaaa  atgttgcag  aaatgcaaa  aaagaatga  cagatgatg  1620
aacagaagg  gaggagtta  caggaacac  tgaaacaac  gactgagaa  atggagaac  1680
acagggtcc  gttgctgaa  gagcaagag  ggaccctcg  tcttaaact  caggaacag  1740
agcaactac  aaaagaggg  tttcaaaaa  aaagcagaa  aatgaaaaa  gagatacag  1800
atctccaga  gaaaatgag  cgacgaaag  catgtacca  aagctaaag  ccagagcct  1860
cctgtcacc  ctaaccaag  cataattga  acaatttta  aatttggaa  aagcgtcac  1920
acatttgat  ataattaga  cttgcatca  aacaccaaa  gtttataaa  gcatgtggt  1980
caatgatca  aatcatgtt  tttcttaaa  aaaaaaaaa  gactgtaaa  tgtgcaaca  2040
agatgcatt  acctctgta  caactcagg  aatctcata  gctggtacc  ctcaggaga  2100
gtttattct  ccagatgac  agcagtaga  aaatggata  tgagcagag  cttaggtaa  2160
agtcttggg  aatatttgg  cattggtct  gccaagtct  caatgtccc  atatcaagg  2220
caaccaccc  agcttctta  tgaagacaa  gtacagtta  ccattagat  aagactaca  2280
ggtctatga  caataatgt  atttctgga  attgcccat  tataatcct  actgatgat  2340
tcaagctaa  gcaaaccac  ttatacaga  atctagaat  tctttatgt  ctccagagg  2400
aggtggaag  aaccatggg  aggagtagg  attgagtga  aaacaattg  gctaatgaa  2460
aaaacttct  ttattgttc  gttcatcca  attataact  caatgggac  ctttagacc  2520
ttagacaat  gacactgga  taaacaaat  cacataatg  caaatacac  atgtattta  2580
agcaacgta  aatttgcaa  gatggactt  aaaagatgc  gtgtaacta  actgaaata  2640
ttcaattac  tattattta  aatgttaaa  cttatgata  tcttttcta  ttcttaaca  2700
tcatacttg  aatctttcc  agtttcccc  gaagagaat  tgggatttt  tttgacatt  2760
ttgacccat  taataatgc  cttgtgttt  cctagtata  gtagacttt  tcttatgtg  2820
caaaagtcc  aggaaagtg  ttgatgttt  ttatagcaa  taaaaatta  ttttgaact  2880
a  2881



<210> 3929
<211> 592
<212> PRT
<213> Homo sapiens
<308> P32455
<400> 3929

Met Ala Ser Glu Ile His Met Thr Gly Pro Met Cys Leu Ile Glu Asn 
  1               5                  10                  15
Thr Asn Gly Arg Leu Met Ala Asn Pro Glu Ala Leu Lys Ile Leu Ser 
             20                  25                  30
Ala Ile Thr Gln Pro Met Val Val Val Ala Ile Val Gly Leu Tyr Arg 
         35                  40                  45
Thr Gly Lys Ser Tyr Leu Met Asn Lys Leu Ala Gly Lys Lys Lys Gly 
     50                  55                  60
Phe Ser Leu Gly Ser Thr Val Gln Ser His Thr Lys Gly Ile Trp Met 
 65                  70                  75                  80
Trp Cys Val Pro His Pro Lys Lys Pro Gly His Ile Leu Val Leu Leu 
                 85                  90                  95
Asp Thr Glu Gly Leu Gly Asp Val Glu Lys Gly Asp Asn Gln Asn Asp 
             100                105                110
Ser Trp Ile Phe Ala Leu Ala Val Leu Leu Ser Ser Thr Phe Val Tyr 
         115                120                125
Asn Ser Ile Gly Thr Ile Asn Gln Gln Ala Met Asp Gln Leu Tyr Tyr 
     130                135                140
Val Thr Glu Leu Thr His Arg Ile Arg Ser Lys Ser Ser Pro Asp Glu 
 145                150                155                160
Asn Glu Asn Glu Val Glu Asp Ser Ala Asp Phe Val Ser Phe Phe Pro 
                 165                170                175
Asp Phe Val Trp Thr Leu Arg Asp Phe Ser Leu Asp Leu Glu Ala Asp 
             180                185                190
Gly Gln Pro Leu Thr Pro Asp Glu Tyr Leu Thr Tyr Ser Leu Lys Leu 
         195                200                205
Lys Lys Gly Thr Ser Gln Lys Asp Glu Thr Phe Asn Leu Pro Arg Leu 
     210                215                220
Cys Ile Arg Lys Phe Phe Pro Lys Lys Lys Cys Phe Val Phe Asp Arg 
 225                230                235                240
Pro Val His Arg Arg Lys Leu Ala Gln Leu Glu Lys Leu Gln Asp Glu 
                 245                250                255
Glu Leu Asp Pro Glu Phe Val Gln Gln Val Ala Asp Phe Cys Ser Tyr 
             260                265                270
Ile Phe Ser Asn Ser Lys Thr Lys Thr Leu Ser Gly Gly Ile Gln Val 
         275                280                285
Asn Gly Pro Arg Leu Glu Ser Leu Val Leu Thr Tyr Val Asn Ala Ile 
     290                295                300
Ser Ser Gly Asp Leu Pro Cys Met Glu Asn Ala Val Leu Ala Leu Ala 
 305                310                315                320
Gln Ile Glu Asn Ser Ala Ala Val Gln Lys Ala Ile Ala His Tyr Glu 
                 325                330                335
Gln Gln Met Gly Gln Lys Val Gln Leu Pro Thr Glu Ser Leu Gln Glu 
             340                345                350
Leu Leu Asp Leu His Arg Asp Ser Glu Arg Glu Ala Ile Glu Val Phe 
         355                360                365
Ile Arg Ser Ser Phe Lys Asp Val Asp His Leu Phe Gln Lys Glu Leu 
     370                375                380
Ala Ala Gln Leu Glu Lys Lys Arg Asp Asp Phe Cys Lys Gln Asn Gln 
 385                390                395                400
Glu Ala Ser Ser Asp Arg Cys Ser Gly Leu Leu Gln Val Ile Phe Ser 
                 405                410                415
Pro Leu Glu Glu Glu Val Lys Ala Gly Ile Tyr Ser Lys Pro Gly Gly 
             420                425                430
Tyr Arg Leu Phe Val Gln Lys Leu Gln Asp Leu Lys Lys Lys Tyr Tyr 
         435                440                445
Glu Glu Pro Arg Lys Gly Ile Gln Ala Glu Glu Ile Leu Gln Thr Tyr 
     450                455                460
Leu Lys Ser Lys Glu Ser Met Thr Asp Ala Ile Leu Gln Thr Asp Gln 
 465                470                475                480
Thr Leu Thr Glu Lys Glu Lys Glu Ile Glu Val Glu Arg Val Lys Ala 
                 485                490                495
Glu Ser Ala Gln Ala Ser Ala Lys Met Leu Gln Glu Met Gln Arg Lys 
             500                505                510
Asn Glu Gln Met Met Glu Gln Lys Glu Arg Ser Tyr Gln Glu His Leu 
         515                520                525
Lys Gln Leu Thr Glu Lys Met Glu Asn Asp Arg Val Gln Leu Leu Lys 
     530                535                540
Glu Gln Glu Arg Thr Leu Ala Leu Lys Leu Gln Glu Gln Glu Gln Leu 
 545                550                555                560
Leu Lys Glu Gly Phe Gln Lys Glu Ser Arg Ile Met Lys Asn Glu Ile 
                 565                570                575
Gln Asp Leu Gln Thr Lys Met Arg Arg Arg Lys Ala Cys Thr Ile Ser 
             580                585                590



<210> 3930
<211> 912
<212> DNA
<213> Rattus norvegicus
<308> M80601
<400> 3930

ccgctcgcc  tcctgctgc  agtgtacgc  ccgcttccg  gtcgggacg  cgccttcca  60
cgtagcctc  ttctcttct  ctgtcgaga  ccgctgtgt  gcgccggcc  gcgagtttt  120
cgtaatcag  taccaagga  aaatgcatt  tactcatat  agccccctt  tgaaacggg  180
gcttcggat  cagaatgtg  gtgcctcca  cttaagtct  gagctcatc  ctgcagggt  240
tgtggttgc  tggccccta  gacatgctc  aggtgcaaa  aggcacatt  ctgcagcaa  300
gaacatcag  cattagact  gcagctcgg  cacaagcag  cttgtacac  gtcagacca  360
ttagaccat  tggttccag  ccataactt  ctgtttcca  aatttgaaa  tgtaacaga  420
acagaagac  agattgggc  tgaggtggt  gaaatggag  attactctg  agttatagg  480
agcatggag  gagtacctg  ggaagaact  gattccatg  caaagcatg  atccaagga  540
gatcacata  tccaaaagt  taaatccaa  atagccctt  aaccagagc  gattctcag  600
tatggaaga  gtattaaac  catctggat  tctggtgaa  atattcctc  agaaaaaga  660
attccagat  gctcatgtg  tgttaagag  atatttgaa  tccaggtca  gcctcagct  720
ttgaaccac  taaaggcag  cagactggg  acaagtgtg  actggggca  cttggctgt  780
ttcacctgt  ctgagagct  cagcctggg  atcgggttc  cagaagaat  tgtgtggaa  840
caggatgtg  cagagacac  atgaaaggt  ttaaattct  aaaaataaa  gttccttat  900
cctcactac  tc  912



<210> 3931
<211> 287
<212> PRT
<213> Rattus norvegicus
<308> P47816
<400> 3931

Pro Leu Ala Phe Leu Leu Gln Val Tyr Ala Pro Leu Pro Gly Arg Asp 
  1               5                  10                  15
Asp Ala Phe His Arg Ser Leu Phe Leu Phe Cys Cys Arg Glu Pro Leu 
             20                  25                  30
Cys Cys Ala Gly Leu Arg Val Phe Arg Asn Gln Leu Pro Arg Lys Asn 
         35                  40                  45
Ala Phe Tyr Ser Tyr Glu Pro Pro Ser Glu Thr Gly Ala Ser Asp Thr 
     50                  55                  60
Glu Cys Val Cys Leu Gln Leu Lys Ser Gly Ala His Leu Cys Arg Val 
 65                  70                  75                  80
Cys Gly Cys Leu Ala Pro Met Thr Cys Ser Arg Cys Lys Gln Ala His 
                 85                  90                  95
Tyr Cys Ser Lys Glu His Gln Thr Leu Asp Trp Gln Leu Gly His Lys 
             100                105                110
Gln Ala Cys Thr Gln Ser Asp His Leu Asp His Met Val Pro Asp His 
         115                120                125
Asn Leu Leu Phe Pro Glu Phe Glu Ile Val Thr Glu Thr Glu Asp Glu 
     130                135                140
Ile Gly Pro Glu Val Val Glu Met Glu Asp Tyr Ser Glu Val Ile Gly 
 145                150                155                160
Ser Met Glu Gly Val Pro Glu Glu Glu Leu Asp Ser Met Ala Lys His 
                 165                170                175
Glu Ser Lys Glu Asp His Ile Phe Gln Lys Phe Lys Ser Lys Ile Ala 
             180                185                190
Leu Glu Pro Glu Gln Ile Leu Arg Tyr Gly Arg Gly Ile Lys Pro Ile 
         195                200                205
Trp Ile Ser Gly Glu Asn Ile Pro Gln Glu Lys Asp Ile Pro Asp Cys 
     210                215                220
Ser Cys Gly Val Lys Arg Ile Phe Glu Phe Gln Val Met Pro Gln Leu 
 225                230                235                240
Leu Asn His Leu Lys Ala Asp Arg Leu Gly Thr Ser Val Asp Trp Gly 
                 245                250                255
Ile Leu Ala Val Phe Thr Cys Ala Glu Ser Cys Ser Leu Gly Ile Gly 
             260                265                270
Phe Thr Glu Glu Phe Val Trp Lys Gln Asp Val Thr Glu Thr Pro 
         275                280                285



<210> 3932
<211> 3254
<212> DNA
<213> Homo sapiens
<308> AK055180
<400> 3932

gagatgttg  ctaaggtac  tgaggttta  gcaccattg  ccccccgcc  gaaagaaaa  60
aggttattt  tgcccattt  caacaggta  ctttggctt  taaaatgtg  catgttaac  120
tttttctcc  taacctccc  taccataaa  gtaaatcac  aaagaaaac  aaactccca  180
aaaccagtc  ctggttcaa  taaatacac  ggaagaata  atctaggtc  taaacacta  240
ggcagtttt  agcaatgca  atgctttta  acaaaatac  gaaaaccac  cagttgctg  300
aggaagctt  ttacagtga  atttactta  gtttgtagt  gttttcaaa  cactatgtt  360
cacttggta  ttgtccctc  taaaatttt  taactatga  ggtaggcac  gactctggg  420
agaattctg  aattagagc  gaggctcat  cttagtccc  tcacaatat  ttcatagga  480
taagttgcc  acattaggt  gtaaaagca  catctggga  atatatttt  atgccctct  540
agtcagata  actgaaata  tcactttga  gtgattgag  aggcattag  ggcacactg  600
tacagccag  tctgatggg  gaactgtga  atgcctttt  ggtcagtgc  acatcaaga  660
taggtacat  catggagta  atagcatgt  accattggc  acttatagg  aaggtattg  720
ttatttgaa  atgatcttc  ttgatttta  attcttaga  atggcagag  tattgcccc  780
atctggatt  ctggtgaaa  tattcctca  gaaaaggat  ttccagatt  cccctgtgg  840
gccaagaga  tattggaat  ccaggtcat  cctcagctc  taaactacc  gaaggctga  900
agactgggc  agagcattg  ctggggcat  ctggctgtc  tcacctgtg  tgagagctg  960
agcttgggt  ctggctata  agaagaatt  gtgtggaag  aggatgtaa  agatacacc  1020
taaaggcat  ttaaagcct  gaaaaatgt  aataatctt  tataccttg  aattccatt  1080
ctgggattt  atcctaagg  aatacttat  ccaaaaata  aggtgcaga  atgttgaca  1140
attgcttac  cagtgtcta  ttattagtg  aacaaaagt  tccagtgac  gggaattaa  1200
taaattttg  tacatccac  gaggaaggc  acacagtct  aattataac  cctatattg  1260
caacagaca  accattata  gtggtattc  tggtatgat  ctattcttg  aaaaatatt  1320
gtatgtatg  acagaaatc  gcaaagatg  acacttagt  aactggtta  caacgaatg  1380
tgggactaa  taaaatggt  tttttactt  tatgtgcat  tctttttat  ataaaaatg  1440
gttatatgc  taatgaagt  aaaccatct  actctgagc  tttcccacc  taggttttt  1500
aaacacaaa  atacttagg  aaaactccc  acaaacttg  ctgatcatt  gctgattat  1560
acaggctct  gtatgtact  gaagcccag  atatttgag  aataccaaa  ctcaggttg  1620
tgagtatga  gaacaggaa  cccagtaat  ctgaagcag  agtatcaca  ttggcagga  1680
gaggaacaa  agtggcttt  tgatcacag  actggaatt  aaagaggct  gaccttcag  1740
actgatctt  gtcagccag  ggccctgct  acagatgag  cactgaaag  caaaaggcg  1800
tggtcttcc  tttccgtgt  agcattgta  acaggttcc  tatcgcaca  acaagggtt  1860
tggaatgta  gccaaaata  gggtctggc  taggaggca  cagcctgag  aaaggaagg  1920
cctgaagtc  gttttcaaa  ggctgaccc  tggcctatt  tgtttctga  acatctgtt  1980
aagcaagcg  ctcctaaga  tacactaag  tttcttcca  cccctagca  ctcacagtt  2040
acaattccc  gttctctca  caccagtga  gcctgccct  aagacacat  gctgttgat  2100
agtgcttga  tactgacgg  taattctga  aaatttctc  ggcttattt  cttaatcta  2160
attggctca  attgtcccc  aacacatcc  tgttaactg  aatgcattg  caccataaa  2220
cctcacgtt  tcataggta  catcacttg  taatgtaat  gtctacttg  ctattttat  2280
tgtaattta  aaagttctg  cctagtagt  catattata  aagtataca  atgcaattt  2340
tattaattg  ataagatag  tatacatag  accatatgg  aaactgcag  atggagttt  2400
tcccatggg  aggttatca  ctacttaag  gctagagga  actagtttc  aacctggga  2460
ggctaaatc  atgaaaatc  cctataact  tggtgtcac  gccctgtgg  tactggagt  2520
agttgtcat  aactagtga  aagagctgg  cgcaacact  agtaggaag  acagtggca  2580
aaggaaacc  ggactagtg  ggcctttat  tctaaaatt  tgtattatt  cttataggc  2640
gaatctgta  gtacgttat  actgctaat  acttttaaa  caaacatgt  aacgatctt  2700
ctatggtaa  aactgttat  tggggacat  accagatga  gtggacatt  ttgcaggta  2760
tttggcata  ccaggcaag  tgtcattgg  gtatattcc  gttaacctc  ggagatgat  2820
gtaacagtt  acagggcct  tccatttgg  atggatata  caagaggga  acaaactgg  2880
ccaaatcac  agaaagaaa  tctcacagc  ccgacttgg  atctgtgtt  aaaaatagc  2940
actatattt  aaataaact  tacaacata  aaaatttaa  ttaaaaaat  cattaagca  3000
gttgccttt  gaaatgtga  gacatttta  aacactaca  gataatgag  aagtctcac  3060
tacataatc  tggctccac  gacggtgcc  gtccatgca  ccaccattt  tcaacacct  3120
caaagtttt  agatctgct  ggttcagat  ctgtccagc  acagcagct  cctctgctg  3180
agagagcag  atattcagc  ttgcctttt  atttcagat  ctgaatatc  tttggcaat  3240
tcagatatc  cagc  3254



<210> 3934
<211> 683
<212> PRT
<213> Rattus norvegicus
<308> Q64319
<400> 3934

Met Asn Glu Asp Lys Asp Lys Arg Asp Ser Ile Gln Met Ser Met Lys 
  1               5                  10                  15
Gly Cys Arg Thr Asn Asn Gly Phe Val Gln Asn Glu Asp Ile Gln Glu 
             20                  25                  30
Gln Asp Pro Asp Ser Arg Asp Thr Pro Gln Ser Asn Ala Val Ser Ile 
         35                  40                  45
Pro Ala Pro Glu Glu Pro Gln Leu Lys Val Val Arg Pro Tyr Ala Gly 
     50                  55                  60
Met Pro Lys Glu Val Leu Phe Gln Phe Ser Gly Gln Ala Arg Tyr Arg 
 65                  70                  75                  80
Val Pro Arg Glu Ile Leu Phe Trp Leu Thr Val Val Ser Val Phe Leu 
                 85                  90                  95
Leu Ile Gly Ala Thr Ile Ala Ile Ile Ile Ile Ser Pro Lys Cys Leu 
             100                105                110
Asp Trp Trp Gln Ala Gly Pro Met Tyr Gln Ile Tyr Pro Arg Ser Phe 
         115                120                125
Lys Asp Ser Asp Lys Asp Gly Asn Gly Asp Leu Lys Gly Ile Gln Glu 
     130                135                140
Lys Leu Asp Tyr Ile Thr Ala Leu Asn Ile Lys Thr Ile Trp Ile Thr 
 145                150                155                160
Ser Phe Tyr Lys Ser Pro Leu Lys Asp Phe Arg Tyr Ala Val Glu Asp 
                 165                170                175
Phe Lys Glu Ile Asp Pro Ile Phe Gly Thr Met Lys Asp Phe Glu Asn 
             180                185                190
Leu Val Ala Ala Val His Asp Lys Gly Leu Lys Leu Ile Ile Asp Phe 
         195                200                205
Ile Pro Asn His Thr Ser Asp Lys His Pro Trp Phe Gln Ser Ser Arg 
     210                215                220
Thr Arg Ser Gly Lys Tyr Thr Asp Tyr Tyr Ile Trp His Asn Cys Thr 
 225                230                235                240
His Ala Asn Gly Val Thr Thr Pro Pro Asn Asn Trp Leu Ser Val Tyr 
                 245                250                255
Gly Asn Ser Ser Trp Gln Phe Asp Glu Glu Arg Lys Gln Cys Tyr Phe 
             260                265                270
His Gln Phe Leu Lys Glu Gln Pro Asp Leu Asn Phe Arg Asn Pro Ala 
         275                280                285
Val Gln Glu Glu Ile Lys Glu Ile Ile Lys Phe Trp Leu Ser Lys Gly 
     290                295                300
Val Asp Gly Phe Ser Phe Asp Ala Val Lys Phe Leu Leu Glu Ala Lys 
 305                310                315                320
Asp Leu Arg Asn Glu Ile Gln Val Asn Thr Ser Gln Ile Pro Asp Thr 
                 325                330                335
Val Thr Arg Tyr Ser Glu Leu Tyr His Asp Phe Thr Thr Thr Gln Val 
             340                345                350
Gly Met His Asp Leu Val Arg Asp Phe Arg Gln Thr Met Asn Gln Phe 
         355                360                365
Ser Arg Glu Pro Gly Arg Tyr Arg Phe Met Gly Thr Glu Val Ser Ala 
     370                375                380
Glu Ser Thr Glu Arg Thr Met Val Tyr Tyr Gly Leu Ser Phe Ile Gln 
 385                390                395                400
Glu Ala Asp Phe Pro Phe Asn Lys Tyr Leu Ala Thr Leu Asp Thr Leu 
                 405                410                415
Ser Gly His Thr Val Tyr Glu Ala Ile Thr Ser Trp Met Glu Asn Met 
             420                425                430
Pro Glu Gly Lys Trp Pro Asn Trp Met Ile Gly Gly Pro Glu Thr Ser 
         435                440                445
Arg Leu Thr Ser Arg Val Gly Ser Glu Tyr Val Asn Ala Met Asn Met 
     450                455                460
Leu Leu Phe Thr Leu Pro Gly Thr Pro Ile Thr Tyr Tyr Gly Glu Glu 
 465                470                475                480
Ile Gly Met Gly Asp Ile Ser Ile Thr Asn Leu Asn Glu Arg Tyr Asp 
                 485                490                495
Thr Asn Ala Leu Leu Ser Lys Ser Pro Met Gln Trp Asp Asn Ser Ser 
             500                505                510
Asn Ala Gly Phe Thr Glu Ala Asn His Thr Trp Leu Pro Thr Asn Ser 
         515                520                525
Asp Tyr His Thr Val Asn Val Asp Val Gln Lys Thr Gln Pro Ser Ser 
     530                535                540
Ala Leu Arg Leu Tyr Gln Asp Leu Ser Leu Leu His Ala Arg Glu Leu 
 545                550                555                560
Leu Leu Ser Arg Gly Trp Phe Cys Leu Leu Arg Asp Asp Asn His Ser 
                 565                570                575
Val Val Tyr Thr Arg Glu Leu Asp Gly Ile Asp Lys Val Phe Leu Val 
             580                585                590
Val Leu Asn Phe Gly Glu Ser Ser Thr Val Leu Asn Leu Gln Glu Thr 
         595                600                605
Ile Ser Asp Val Pro Thr Lys Leu Arg Ile Arg Leu Ser Thr Asn Pro 
     610                615                620
Ala Ser Lys Gly Ser Asp Val Asp Thr His Ala Val Ser Leu Glu Lys 
 625                630                635                640
Gly Glu Gly Leu Ile Leu Glu His Ser Met Lys Thr Leu Leu His His 
                 645                650                655
Gln Lys Ala Phe Arg Asp Lys Cys Phe Ile Ser Asn Arg Ala Cys Tyr 
             660                665                670
Ser Ser Val Leu Asp Leu Leu Tyr Ser Ser Cys 
         675                680



<210> 3935
<211> 2283
<212> DNA
<213> Homo sapiens
<308> L11696
<400> 3935

cct  2283



<210> 3936
<211> 685
<212> PRT
<213> Homo sapiens
<308> Q07837
<400> 3936

Met Ala Glu Asp Lys Ser Lys Arg Asp Ser Ile Glu Met Ser Met Lys 
  1               5                  10                  15
Gly Cys Gln Thr Asn Asn Gly Phe Val His Asn Glu Asp Ile Leu Glu 
             20                  25                  30
Gln Thr Pro Asp Pro Gly Ser Ser Thr Asp Asn Leu Lys His Ser Thr 
         35                  40                  45
Arg Gly Ile Leu Gly Ser Gln Glu Pro Asp Phe Lys Gly Val Gln Pro 
     50                  55                  60
Tyr Ala Gly Met Pro Lys Glu Val Leu Phe Gln Phe Ser Gly Gln Ala 
 65                  70                  75                  80
Arg Tyr Arg Ile Pro Arg Glu Ile Leu Phe Trp Leu Thr Val Ala Ser 
                 85                  90                  95
Val Leu Val Leu Ile Ala Ala Thr Ile Ala Ile Ile Ala Leu Ser Pro 
             100                105                110
Lys Cys Leu Asp Trp Trp Gln Glu Gly Pro Met Tyr Gln Ile Tyr Pro 
         115                120                125
Arg Ser Phe Lys Asp Ser Asn Lys Asp Gly Asn Gly Asp Leu Lys Gly 
     130                135                140
Ile Gln Asp Lys Leu Asp Tyr Ile Thr Ala Leu Asn Ile Lys Thr Val 
 145                150                155                160
Trp Ile Thr Ser Phe Tyr Lys Ser Ser Leu Lys Asp Phe Arg Tyr Gly 
                 165                170                175
Val Glu Asp Phe Arg Glu Val Asp Pro Ile Phe Gly Thr Met Glu Asp 
             180                185                190
Phe Glu Asn Leu Val Ala Ala Ile His Asp Lys Gly Leu Lys Leu Ile 
         195                200                205
Ile Asp Phe Ile Pro Asn His Thr Ser Asp Lys His Ile Trp Phe Gln 
     210                215                220
Leu Ser Arg Thr Arg Thr Gly Lys Tyr Thr Asp Tyr Tyr Ile Trp His 
 225                230                235                240
Asp Cys Thr His Glu Asn Gly Lys Thr Ile Pro Pro Asn Asn Trp Leu 
                 245                250                255
Ser Val Tyr Gly Asn Ser Ser Trp His Phe Asp Glu Val Arg Asn Gln 
             260                265                270
Cys Tyr Phe His Gln Phe Met Lys Glu Gln Pro Asp Leu Asn Phe Arg 
         275                280                285
Asn Pro Asp Val Gln Glu Glu Ile Lys Glu Ile Leu Arg Phe Trp Leu 
     290                295                300
Thr Lys Gly Val Asp Gly Phe Ser Leu Asp Ala Val Lys Phe Leu Leu 
 305                310                315                320
Glu Ala Lys His Leu Arg Asp Glu Ile Gln Val Asn Lys Thr Gln Ile 
                 325                330                335
Pro Asp Thr Val Thr Gln Tyr Ser Glu Leu Tyr His Asp Phe Thr Thr 
             340                345                350
Thr Gln Val Gly Met His Asp Ile Val Arg Ser Phe Arg Gln Thr Met 
         355                360                365
Asp Gln Tyr Ser Thr Glu Pro Gly Arg Tyr Arg Phe Met Gly Thr Glu 
     370                375                380
Ala Tyr Ala Glu Ser Ile Asp Arg Thr Val Met Tyr Tyr Gly Leu Pro 
 385                390                395                400
Phe Ile Gln Glu Ala Asp Phe Pro Phe Asn Asn Tyr Leu Ser Met Leu 
                 405                410                415
Asp Thr Val Ser Gly Asn Ser Val Tyr Glu Val Ile Thr Ser Trp Met 
             420                425                430
Glu Asn Met Pro Glu Gly Lys Trp Pro Asn Trp Met Ile Gly Gly Pro 
         435                440                445
Asp Ser Ser Arg Leu Thr Ser Arg Leu Gly Asn Gln Tyr Val Asn Val 
     450                455                460
Met Asn Met Leu Leu Phe Thr Leu Pro Gly Thr Pro Ile Thr Tyr Tyr 
 465                470                475                480
Gly Glu Glu Ile Gly Met Gly Asn Ile Val Ala Ala Asn Leu Asn Glu 
                 485                490                495
Ser Tyr Asp Ile Asn Thr Leu Arg Ser Lys Ser Pro Met Gln Trp Asp 
             500                505                510
Asn Ser Ser Asn Ala Gly Phe Ser Glu Ala Ser Asn Thr Trp Leu Pro 
         515                520                525
Thr Asn Ser Asp Tyr His Thr Val Asn Val Asp Val Gln Lys Thr Gln 
     530                535                540
Pro Arg Ser Ala Leu Lys Leu Tyr Gln Asp Leu Ser Leu Leu His Ala 
 545                550                555                560
Asn Glu Leu Leu Leu Asn Arg Gly Trp Phe Cys His Leu Arg Asn Asp 
                 565                570                575
Ser His Tyr Val Val Tyr Thr Arg Glu Leu Asp Gly Ile Asp Arg Ile 
             580                585                590
Phe Ile Val Val Leu Asn Phe Gly Glu Ser Thr Leu Leu Asn Leu His 
         595                600                605
Asn Met Ile Ser Gly Leu Pro Ala Lys Ile Arg Ile Arg Leu Ser Thr 
     610                615                620
Asn Ser Ala Asp Lys Gly Ser Lys Val Asp Thr Ser Gly Ile Phe Leu 
 625                630                635                640
Asp Lys Gly Glu Gly Leu Ile Phe Glu His Asn Thr Lys Asn Leu Leu 
                 645                650                655
His Arg Gln Thr Ala Phe Arg Asp Arg Cys Phe Val Ser Asn Arg Ala 
             660                665                670
Cys Tyr Ser Ser Val Leu Asn Ile Leu Tyr Thr Ser Cys 
         675                680                685



<210> 3937
<211> 3418
<212> DNA
<213> Rattus norvegicus
<308> M81642
<400> 3937

cccacgcgt  cggtgagct  ctcctaaga  agtaggcga  cgcgcgctc  gccgcgcgg  60
cagcctcgg  acaatgggg  cccggcgct  gctgctcgt  gcggtcggc  tcagcctgt  120
cggtccttt  ctgtcttcc  gcgttccta  gagacagcc  gaatctgag  ggatgtatg  180
tacgccgta  gctacgcca  acccccgct  attttttct  aggaatccc  gtgaagata  240
atttgaaca  ttcccccta  gggatgagg  ggagaaaaa  gaaagcata  cgctcgagg  300
cagggcagt  tacttaaat  aaagccgtt  tcctcccat  ccgcctcct  ccttcatct  360
cgaggacgc  tccggatat  tgaccagcc  ctggctgac  ctcttcata  cctccgtgt  420
cacgtttgt  ttcatagtc  gccttcccc  gaacatcct  gccatcgct  tgtttgtct  480
tcggatgaa  gtcaagaag  cggccgtgg  gtacatgct  cacctggcc  tggccgatg  540
cctcttcgt  tccgtgctc  ccttcaaga  cagctacta  ttctccggc  ccgattggc  600
gttcgggtc  ggaatgtgt  gcttcgcca  cgcagcgtg  tattgtaac  tgtacgcct  660
catcatgct  atgacagtc  taagcattg  ccggttcct  gcagtggtg  accccatcc  720
gtccctgtc  tggcgcact  tgggccgag  caacttcac  tgcgtggtc  tctgggtga  780
ggccatcat  ggggtggtg  ccctcctcc  caaagagca  accacccag  ttccggggc  840
caacatcac  acctgccac  acgtcctca  cgagaccct  ctgcatggc  tttactcgt  900
ctatttctc  gccttctcc  ccatcttct  tcttgtgcc  ttgatcatt  ccacagtct  960
ctacacgtc  atcatccga  gcctcagct  ctccgcggt  gcgaaccgg  gcaagaagt  1020
gcgggcttt  ttcctgtcc  ccgccgtgt  ctgcatctt  atcgtctgc  ttgggccca  1080
caacgtcct  ctgattgtg  actacctgc  cctctccga  agtcctggc  cagagacgg  1140
ctattttgc  tacctcctc  gcgtctgcg  gacgagcgt  gctagctgc  tcgacccct  1200
gatttacta  tatgcctcc  ccgagtgcc  gaagcacct  tacagcatt  tgtgctgca  1260
agaaagctc  gattccaac  gttgcaaca  caccggcca  ctgatgccc  gtaagatgg  1320
tacctgctc  agccacctg  ataatagca  atacaaaaa  ctactagct  agggaaagg  1380
tggctggaa  gttccatga  gaaaaggtt  gaaagtgaa  agctgggga  cccccatca  1440
tccctggca  gaactgtat  gacttcaac  ccttaagaa  accgccaac  tctgatttg  1500
atgcatact  cttacaagt  ctatcaagt  tatagattg  ataatcacc  gcaaggtga  1560
gggaacgga  tcaaggttt  cagtgttgc  tagtgctgg  atagtagtt  agcgtcacc  1620
cttctatat  taggtgact  taacataca  gtggtgtgc  cacacacag  ggcagtgca  1680
ggtggattc  gcgctttga  gctttcttg  ttattccct  gacagttgc  atagaaata  1740
tctgattct  tgacttaat  aagtctggg  tggtggatg  tatgccctg  gcagctgaa  1800
accccagtg  tagggaaga  gcccatagt  tagacttaa  acagctttt  cctatgtgt  1860
tatatttat  tattttcaa  tatttgata  gtaatgttt  gtgatggaa  gatgagaca  1920
tattacctg  gtaggggaa  gtcttgaac  accacagtt  aagaattat  aaagcagtt  1980
aaaagcccc  ttttgatac  caatttact  acaaaatac  tggaccaag  ctgagcata  2040
gactcgcca  gaatgtaag  aacctttca  agcagccaa  cctgataac  agacacagc  2100
atctgcatg  aggcctctg  gcatgaggt  tatcatacc  cttcagcta  gcctcccag  2160
gagcagaga  gaggaccac  aggcccact  caccctgct  ggggtctca  ttgctgtga  2220
ctgattatg  caattagaa  ttggcaagg  aggggatgc  atcttggga  gcagtaaca  2280
ctgcacatc  gacaatcgg  gaaaggtgt  tttacatcc  gcagctgtc  cgcaagctg  2340
cccttgcac  gacagacac  cccatgtgc  ctggtcaca  tgttggata  tgggccgta  2400
actgactga  tgtcggaga  tagctgagt  ctgccctta  tcaggcagc  cagagagct  2460
gcacgcggt  agctgtgac  tatgcgctg  aaaccatcg  acatagaag  tgtcattag  2520
tggatgtca  caagcatat  tcacacaag  acggcctat  agctaaacc  ctttggata  2580
ctgagtctc  gcttccggt  actatagat  gggataaag  cacaataca  gatgtatat  2640
tttaataca  aagcccttc  gtctacaat  attagatgc  attattaca  atgttttgt  2700
aaaaattac  cagatcagc  tggcatttt  tcgcatgcc  ttaagccca  taggtggga  2760
gcagaggca  tcagatggt  aacaacttt  ttttttttt  ttctttttt  cagagctgg  2820
gaccgaacc  aggaccttg  gcttgctcg  caagtgctc  accactgag  taaatcccc  2880
accccggta  acaactttt  taagaagca  gcaaacaca  tgaagtcca  ttttaagaa  2940
tatataggt  agtttggtt  aaaataata  taatgaaag  aaatttcat  gattgaaat  3000
gattgcaat  taggaaaat  agcctgtat  tctctcaag  gttactgaa  ttgttttta  3060
agtctttta  tgccacagt  actaacaag  atataaaaa  cttcatgcc  ttgacaaat  3120
aatttagaa  ttaatttaa  acatatcct  ttcctggtt  aaaaaatat  ttggcattt  3180
aagcagata  gactagaaa  tatttaaga  aacaaagta  ttcccaata  tgtagaata  3240
cttccatga  actccccta  ttgtctggt  aactcggtt  ctgtgttga  ttatctaaa  3300
cattgactc  ctgtcctgt  ctctgtgac  taacgtaac  gttaccact  cacttgtga  3360
ctttcgtgt  attgttttg  gttcaccct  tttttttaa  aaatatatt  ataaacta  3418



<210> 3938
<211> 432
<212> PRT
<213> Rattus norvegicus
<308> P26824
<400> 3938

Met Gly Pro Arg Arg Leu Leu Leu Val Ala Val Gly Leu Ser Leu Cys 
  1               5                  10                  15
Gly Pro Leu Leu Ser Ser Arg Val Pro Met Arg Gln Pro Glu Ser Glu 
             20                  25                  30
Arg Met Tyr Ala Thr Pro Tyr Ala Thr Pro Asn Pro Arg Ser Phe Phe 
         35                  40                  45
Leu Arg Asn Pro Ser Glu Asp Thr Phe Glu Gln Phe Pro Leu Gly Asp 
     50                  55                  60
Glu Glu Glu Lys Asn Glu Ser Ile Pro Leu Glu Gly Arg Ala Val Tyr 
 65                  70                  75                  80
Leu Asn Lys Ser Arg Phe Pro Pro Met Pro Pro Pro Pro Phe Ile Ser 
                 85                  90                  95
Glu Asp Ala Ser Gly Tyr Leu Thr Ser Pro Trp Leu Thr Leu Phe Ile 
             100                105                110
Pro Ser Val Tyr Thr Phe Val Phe Ile Val Ser Leu Pro Leu Asn Ile 
         115                120                125
Leu Ala Ile Ala Val Phe Val Phe Arg Met Lys Val Lys Lys Pro Ala 
     130                135                140
Val Val Tyr Met Leu His Leu Ala Met Ala Asp Val Leu Phe Val Ser 
 145                150                155                160
Val Leu Pro Phe Lys Ile Ser Tyr Tyr Phe Ser Gly Thr Asp Trp Gln 
                 165                170                175
Phe Gly Ser Gly Met Cys Arg Phe Ala Thr Ala Ala Cys Tyr Cys Asn 
             180                185                190
Met Tyr Ala Ser Ile Met Leu Met Thr Val Ile Ser Ile Asp Arg Phe 
         195                200                205
Leu Ala Val Val Tyr Pro Ile Gln Ser Leu Ser Trp Arg Thr Leu Gly 
     210                215                220
Arg Ala Asn Phe Thr Cys Val Val Ile Trp Val Met Ala Ile Met Gly 
 225                230                235                240
Val Val Pro Leu Leu Leu Lys Glu Gln Thr Thr Gln Val Pro Gly Leu 
                 245                250                255
Asn Ile Thr Thr Cys His Asp Val Leu Asn Glu Thr Leu Leu His Gly 
             260                265                270
Phe Tyr Ser Tyr Tyr Phe Ser Ala Phe Ser Ala Ile Phe Phe Leu Val 
         275                280                285
Pro Leu Ile Ile Ser Thr Val Cys Tyr Thr Ser Ile Ile Arg Cys Leu 
     290                295                300
Ser Ser Ser Ala Val Ala Asn Arg Ser Lys Lys Ser Arg Ala Leu Phe 
 305                310                315                320
Leu Ser Ala Ala Val Phe Cys Ile Phe Ile Val Cys Phe Gly Pro Thr 
                 325                330                335
Asn Val Leu Leu Ile Val His Tyr Leu Leu Leu Ser Asp Ser Pro Gly 
             340                345                350
Thr Glu Thr Ala Tyr Phe Ala Tyr Leu Leu Cys Val Cys Val Thr Ser 
         355                360                365
Val Ala Ser Cys Ile Asp Pro Leu Ile Tyr Tyr Tyr Ala Ser Ser Glu 
     370                375                380
Cys Gln Lys His Leu Tyr Ser Ile Leu Cys Cys Arg Glu Ser Ser Asp 
 385                390                395                400
Ser Asn Ser Cys Asn Ser Thr Gly Gln Leu Met Pro Ser Lys Met Asp 
                 405                410                415
Thr Cys Ser Ser His Leu Asn Asn Ser Ile Tyr Lys Lys Leu Leu Ala 
             420                425                430



<210> 3939
<211> 3472
<212> DNA
<213> Homo sapiens
<308> M62424
<400> 3939

gcgcccgcg  gaccgcgcg  cccagtccc  ccccgcccc  ctaaccgcc  cagacacag  60
gctcgccga  ggtcgcttg  accctgatc  tacccgtgg  caccctgcg  tctgcctgc  120
gcgaagacc  gctccccga  ccgcagaag  caggagaga  ggtgaagcg  agcagcccg  180
ggcggggca  cctcccgga  cagcgccgc  cagagcccg  gacaatggg  ccgcggcgg  240
tgctgctgg  ggccgcctg  ttcagtctg  gcggcccgc  gttgtctgc  cgcacccgg  300
cccgcaggc  agaatcaaa  gcaacaaat  ccaccttag  tccccggtc  tttcttctc  360
ggaacccca  tgataaata  gaaccattt  gggaggatg  ggagaaaaa  gaaagtggg  420
taactgaat  cagattagt  tccatcaat  aaagcagtc  tcttcaaaa  caacttcct  480
cattcatct  agaagatgc  tccggatat  tgaccagct  ctggctgac  ctctttgtc  540
catctgtgt  caccggagt  tttgtagtc  gcctcccac  aaacatcat  gccatcgtt  600
tgttcatcc  gaaaatgaa  gtcaagaag  cggcggtgg  gtacatgct  cacctggcc  660
cggcagatg  gctgtttgt  tctgtgctc  cctttaaga  cagctatta  ttttccggc  720
gtgattggc  gtttgggtc  gaattgtgt  gcttcgtca  tgcagcatt  tactgtaac  780
tgtacgcct  tatcttgct  atgacagtc  taagcattg  ccggtttct  gctgtggtg  840
atcccatgc  gtccctctc  tggcgtact  tgggaaggg  ttccttcac  tgtctggcc  900
tctgggctt  ggccatcgc  ggggtagtg  ctctcgtcc  caaggagca  accatccag  960
tgcccgggc  caacatcac  acctgtcat  atgtgctca  tgaaaccct  ctcgaaggc  1020
actatgcct  ctacttctc  gccttctct  ctgtcttct  ttttgtgcc  ctgatcatt  1080
ccacggtct  ttatgtgtc  atcattcga  gtcttagct  ttccgcagt  gccaaccgc  1140
gcaagaagt  ccgggcttt  ttcctgtca  ctgctgttt  ctgcatctt  atcatttgc  1200
tcggaccca  aaacgtcct  ctgattgcg  attactcat  cctttctca  acttccacc  1260
cagaggctg  ctactttgc  tacctcctc  gtgtctgtg  cagcagcat  agctcgtgc  1320
tcgaccccc  aatttacta  tacgcttcc  ctgagtgcc  gaggtacgt  tacagtatc  1380
tatgctgca  agaaagttc  gatcccagc  gttataaca  cagtgggca  ttgatggca  1440
gtaaaatgg  tacctgctc  agtaacctg  ataacagca  atacaaaaa  ctgttaact  1500
aggaaaagg  actgctggg  ggttaaaaa  aaaagttta  aaaagtgaa  aacctgagg  1560
ttctattag  ccccaccca  actttattg  ttcacctcc  aaaacaaca  atgtacgac  1620
tgcatacct  ctttttatg  gagctgtca  gcatgtatt  ttgtcaatt  ccagaaaga  1680
aacaggacg  gatgacggt  ttattccaa  ggaatattg  caatgctac  gtaataaat  1740
aatgtcact  ctggatata  ctaggtgac  tatacatac  tacatgtgt  tatatgtag  1800
tgtatgcac  cacatatat  atttgcagt  cagtataga  taggcactt  aaaacactc  1860
ttccccgca  cccagcaat  atgaaaata  tctctgatt  cctgattta  tatgcaaag  1920
ctaggttgg  agagtttag  cctgaacat  tcatggtgt  catcaacag  gagagactc  1980
atagtttgg  cttgtacca  ttttgcaaa  aagtgtatt  tgaaattgt  tgacggcaa  2040
gtttaagtt  ttaagaggt  agacttagt  ctatctgtg  gtagaagtt  tagtgtttt  2100
aattttaaa  atatccaag  ttgaattcc  aaaattatg  aaacagatg  aaagcctct  2160
ttttgatat  ggtagtatt  tttacattt  acacactgt  cacataagc  aaaactgag  2220
ataagtcct  tagtgaatg  aggctggct  tcagagtag  ctattcctg  gagctgcat  2280
tgtccgccc  cgatggagg  ctccaggca  cagacacat  ccagggcca  gtcagacac  2340
gattggcca  aaaccttcc  gctgagcct  acagcagtg  gactggggc  actacattt  2400
ctccatcct  ctgggattg  ctgtgaact  atcatgttt  tgagaaact  gcaaagcag  2460
atgtgatat  ctaggaggt  atgaccatg  aagacttct  tacccatct  aaaaacaac  2520
aaagaaggc  tggacttct  gatgcccat  cactgggtg  aaacacatc  agtagttgt  2580
ctgaaatgt  agttctgat  tggaagcac  cattatgcg  tgtggccac  ccaataggt  2640
ctgagtgta  agagtggaa  aagacagag  cctgccctc  agagcaaag  agatcatgc  2700
tagagtgtg  tgtatgtgt  ataaatatg  ttcacacaa  caaggcctg  cagctaaag  2760
agtttgaac  tttgggtta  tatttcttg  ggttataac  taatgaaaa  aatgcagta  2820
aggacatat  ttttttaaa  taagtctga  ttaattggg  actatttat  tacaaatgt  2880
ttgctcaat  gattgctca  atcaggttt  cttttaaga  tcaatcatg  cagtctgct  2940
agaaataac  gaagaaaat  gaattgaca  tgaaatcta  gaaaattat  ctataattt  3000
catttactt  agacttaat  agactttaa  agcattttt  aacctccta  gtatcaagt  3060
tagaaaatc  tcatggaat  cacaaagta  tttggaaat  aggttgaaa  atatctctt  3120
tcttacgaa  aaatggtag  attttaaac  aaatagaaa  ttgcaaggc  aatgtttat  3180
taaaagagc  ggccaggcg  ggtggctca  gcctgtaat  ccagcactt  gggaggctg  3240
ggcgggtgg  tcacgaggt  aggagatcg  gaccatcct  gctaacacg  tgaaacccg  3300
ctctactaa  aatgcaaaa  aaattagcc  ggcgtggtg  caggcacct  tagtcccag  3360
tactcggga  gctgaggca  gagactggc  tgaacccag  aggcggacc  tgtagtgag  3420
cgagatcgc  ccactgtgc  ccagcctgg  caacagagc  agactccat  tc  3472



<210> 3940
<211> 425
<212> PRT
<213> Homo sapiens
<308> P25116
<400> 3940

Met Gly Pro Arg Arg Leu Leu Leu Val Ala Ala Cys Phe Ser Leu Cys 
  1               5                  10                  15
Gly Pro Leu Leu Ser Ala Arg Thr Arg Ala Arg Arg Pro Glu Ser Lys 
             20                  25                  30
Ala Thr Asn Ala Thr Leu Asp Pro Arg Ser Phe Leu Leu Arg Asn Pro 
         35                  40                  45
Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp Glu Glu Lys Asn Glu Ser 
     50                  55                  60
Gly Leu Thr Glu Tyr Arg Leu Val Ser Ile Asn Lys Ser Ser Pro Leu 
 65                  70                  75                  80
Gln Lys Gln Leu Pro Ala Phe Ile Ser Glu Asp Ala Ser Gly Tyr Leu 
                 85                  90                  95
Thr Ser Ser Trp Leu Thr Leu Phe Val Pro Ser Val Tyr Thr Gly Val 
             100                105                110
Phe Val Val Ser Leu Pro Leu Asn Ile Met Ala Ile Val Val Phe Ile 
         115                120                125
Leu Lys Met Lys Val Lys Lys Pro Ala Val Val Tyr Met Leu His Leu 
     130                135                140
Ala Thr Ala Asp Val Leu Phe Val Ser Val Leu Pro Phe Lys Ile Ser 
 145                150                155                160
Tyr Tyr Phe Ser Gly Ser Asp Trp Gln Phe Gly Ser Glu Leu Cys Arg 
                 165                170                175
Phe Val Thr Ala Ala Phe Tyr Cys Asn Met Tyr Ala Ser Ile Leu Leu 
             180                185                190
Met Thr Val Ile Ser Ile Asp Arg Phe Leu Ala Val Val Tyr Pro Met 
         195                200                205
Gln Ser Leu Ser Trp Arg Thr Leu Gly Arg Ala Ser Phe Thr Cys Leu 
     210                215                220
Ala Ile Trp Ala Leu Ala Ile Ala Gly Val Val Pro Leu Leu Leu Lys 
 225                230                235                240
Glu Gln Thr Ile Gln Val Pro Gly Leu Asn Ile Thr Thr Cys His Asp 
                 245                250                255
Val Leu Asn Glu Thr Leu Leu Glu Gly Tyr Tyr Ala Tyr Tyr Phe Ser 
             260                265                270
Ala Phe Ser Ala Val Phe Phe Phe Val Pro Leu Ile Ile Ser Thr Val 
         275                280                285
Cys Tyr Val Ser Ile Ile Arg Cys Leu Ser Ser Ser Ala Val Ala Asn 
     290                295                300
Arg Ser Lys Lys Ser Arg Ala Leu Phe Leu Ser Ala Ala Val Phe Cys 
 305                310                315                320
Ile Phe Ile Ile Cys Phe Gly Pro Thr Asn Val Leu Leu Ile Ala His 
                 325                330                335
Tyr Ser Phe Leu Ser His Thr Ser Thr Thr Glu Ala Ala Tyr Phe Ala 
             340                345                350
Tyr Leu Leu Cys Val Cys Val Ser Ser Ile Ser Cys Cys Ile Asp Pro 
         355                360                365
Leu Ile Tyr Tyr Tyr Ala Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser 
     370                375                380
Ile Leu Cys Cys Lys Glu Ser Ser Asp Pro Ser Ser Tyr Asn Ser Ser 
 385                390                395                400
Gly Gln Leu Met Ala Ser Lys Met Asp Thr Cys Ser Ser Asn Leu Asn 
                 405                410                415
Asn Ser Ile Tyr Lys Lys Leu Leu Thr 
             420                425



<210> 3941
<211> 3418
<212> DNA
<213> Rattus norvegicus
<308> M81642
<400> 3941

cccacgcgt  cggtgagct  ctcctaaga  agtaggcga  cgcgcgctc  gccgcgcgg  60
cagcctcgg  acaatgggg  cccggcgct  gctgctcgt  gcggtcggc  tcagcctgt  120
cggtccttt  ctgtcttcc  gcgttccta  gagacagcc  gaatctgag  ggatgtatg  180
tacgccgta  gctacgcca  acccccgct  attttttct  aggaatccc  gtgaagata  240
atttgaaca  ttcccccta  gggatgagg  ggagaaaaa  gaaagcata  cgctcgagg  300
cagggcagt  tacttaaat  aaagccgtt  tcctcccat  ccgcctcct  ccttcatct  360
cgaggacgc  tccggatat  tgaccagcc  ctggctgac  ctcttcata  cctccgtgt  420
cacgtttgt  ttcatagtc  gccttcccc  gaacatcct  gccatcgct  tgtttgtct  480
tcggatgaa  gtcaagaag  cggccgtgg  gtacatgct  cacctggcc  tggccgatg  540
cctcttcgt  tccgtgctc  ccttcaaga  cagctacta  ttctccggc  ccgattggc  600
gttcgggtc  ggaatgtgt  gcttcgcca  cgcagcgtg  tattgtaac  tgtacgcct  660
catcatgct  atgacagtc  taagcattg  ccggttcct  gcagtggtg  accccatcc  720
gtccctgtc  tggcgcact  tgggccgag  caacttcac  tgcgtggtc  tctgggtga  780
ggccatcat  ggggtggtg  ccctcctcc  caaagagca  accacccag  ttccggggc  840
caacatcac  acctgccac  acgtcctca  cgagaccct  ctgcatggc  tttactcgt  900
ctatttctc  gccttctcc  ccatcttct  tcttgtgcc  ttgatcatt  ccacagtct  960
ctacacgtc  atcatccga  gcctcagct  ctccgcggt  gcgaaccgg  gcaagaagt  1020
gcgggcttt  ttcctgtcc  ccgccgtgt  ctgcatctt  atcgtctgc  ttgggccca  1080
caacgtcct  ctgattgtg  actacctgc  cctctccga  agtcctggc  cagagacgg  1140
ctattttgc  tacctcctc  gcgtctgcg  gacgagcgt  gctagctgc  tcgacccct  1200
gatttacta  tatgcctcc  ccgagtgcc  gaagcacct  tacagcatt  tgtgctgca  1260
agaaagctc  gattccaac  gttgcaaca  caccggcca  ctgatgccc  gtaagatgg  1320
tacctgctc  agccacctg  ataatagca  atacaaaaa  ctactagct  agggaaagg  1380
tggctggaa  gttccatga  gaaaaggtt  gaaagtgaa  agctgggga  cccccatca  1440
tccctggca  gaactgtat  gacttcaac  ccttaagaa  accgccaac  tctgatttg  1500
atgcatact  cttacaagt  ctatcaagt  tatagattg  ataatcacc  gcaaggtga  1560
gggaacgga  tcaaggttt  cagtgttgc  tagtgctgg  atagtagtt  agcgtcacc  1620
cttctatat  taggtgact  taacataca  gtggtgtgc  cacacacag  ggcagtgca  1680
ggtggattc  gcgctttga  gctttcttg  ttattccct  gacagttgc  atagaaata  1740
tctgattct  tgacttaat  aagtctggg  tggtggatg  tatgccctg  gcagctgaa  1800
accccagtg  tagggaaga  gcccatagt  tagacttaa  acagctttt  cctatgtgt  1860
tatatttat  tattttcaa  tatttgata  gtaatgttt  gtgatggaa  gatgagaca  1920
tattacctg  gtaggggaa  gtcttgaac  accacagtt  aagaattat  aaagcagtt  1980
aaaagcccc  ttttgatac  caatttact  acaaaatac  tggaccaag  ctgagcata  2040
gactcgcca  gaatgtaag  aacctttca  agcagccaa  cctgataac  agacacagc  2100
atctgcatg  aggcctctg  gcatgaggt  tatcatacc  cttcagcta  gcctcccag  2160
gagcagaga  gaggaccac  aggcccact  caccctgct  ggggtctca  ttgctgtga  2220
ctgattatg  caattagaa  ttggcaagg  aggggatgc  atcttggga  gcagtaaca  2280
ctgcacatc  gacaatcgg  gaaaggtgt  tttacatcc  gcagctgtc  cgcaagctg  2340
cccttgcac  gacagacac  cccatgtgc  ctggtcaca  tgttggata  tgggccgta  2400
actgactga  tgtcggaga  tagctgagt  ctgccctta  tcaggcagc  cagagagct  2460
gcacgcggt  agctgtgac  tatgcgctg  aaaccatcg  acatagaag  tgtcattag  2520
tggatgtca  caagcatat  tcacacaag  acggcctat  agctaaacc  ctttggata  2580
ctgagtctc  gcttccggt  actatagat  gggataaag  cacaataca  gatgtatat  2640
tttaataca  aagcccttc  gtctacaat  attagatgc  attattaca  atgttttgt  2700
aaaaattac  cagatcagc  tggcatttt  tcgcatgcc  ttaagccca  taggtggga  2760
gcagaggca  tcagatggt  aacaacttt  ttttttttt  ttctttttt  cagagctgg  2820
gaccgaacc  aggaccttg  gcttgctcg  caagtgctc  accactgag  taaatcccc  2880
accccggta  acaactttt  taagaagca  gcaaacaca  tgaagtcca  ttttaagaa  2940
tatataggt  agtttggtt  aaaataata  taatgaaag  aaatttcat  gattgaaat  3000
gattgcaat  taggaaaat  agcctgtat  tctctcaag  gttactgaa  ttgttttta  3060
agtctttta  tgccacagt  actaacaag  atataaaaa  cttcatgcc  ttgacaaat  3120
aatttagaa  ttaatttaa  acatatcct  ttcctggtt  aaaaaatat  ttggcattt  3180
aagcagata  gactagaaa  tatttaaga  aacaaagta  ttcccaata  tgtagaata  3240
cttccatga  actccccta  ttgtctggt  aactcggtt  ctgtgttga  ttatctaaa  3300
cattgactc  ctgtcctgt  ctctgtgac  taacgtaac  gttaccact  cacttgtga  3360
ctttcgtgt  attgttttg  gttcaccct  tttttttaa  aaatatatt  ataaacta  3418



<210> 3942
<211> 432
<212> PRT
<213> Rattus norvegicus
<308> P26824
<400> 3942

Met Gly Pro Arg Arg Leu Leu Leu Val Ala Val Gly Leu Ser Leu Cys 
  1               5                  10                  15
Gly Pro Leu Leu Ser Ser Arg Val Pro Met Arg Gln Pro Glu Ser Glu 
             20                  25                  30
Arg Met Tyr Ala Thr Pro Tyr Ala Thr Pro Asn Pro Arg Ser Phe Phe 
         35                  40                  45
Leu Arg Asn Pro Ser Glu Asp Thr Phe Glu Gln Phe Pro Leu Gly Asp 
     50                  55                  60
Glu Glu Glu Lys Asn Glu Ser Ile Pro Leu Glu Gly Arg Ala Val Tyr 
 65                  70                  75                  80
Leu Asn Lys Ser Arg Phe Pro Pro Met Pro Pro Pro Pro Phe Ile Ser 
                 85                  90                  95
Glu Asp Ala Ser Gly Tyr Leu Thr Ser Pro Trp Leu Thr Leu Phe Ile 
             100                105                110
Pro Ser Val Tyr Thr Phe Val Phe Ile Val Ser Leu Pro Leu Asn Ile 
         115                120                125
Leu Ala Ile Ala Val Phe Val Phe Arg Met Lys Val Lys Lys Pro Ala 
     130                135                140
Val Val Tyr Met Leu His Leu Ala Met Ala Asp Val Leu Phe Val Ser 
 145                150                155                160
Val Leu Pro Phe Lys Ile Ser Tyr Tyr Phe Ser Gly Thr Asp Trp Gln 
                 165                170                175
Phe Gly Ser Gly Met Cys Arg Phe Ala Thr Ala Ala Cys Tyr Cys Asn 
             180                185                190
Met Tyr Ala Ser Ile Met Leu Met Thr Val Ile Ser Ile Asp Arg Phe 
         195                200                205
Leu Ala Val Val Tyr Pro Ile Gln Ser Leu Ser Trp Arg Thr Leu Gly 
     210                215                220
Arg Ala Asn Phe Thr Cys Val Val Ile Trp Val Met Ala Ile Met Gly 
 225                230                235                240
Val Val Pro Leu Leu Leu Lys Glu Gln Thr Thr Gln Val Pro Gly Leu 
                 245                250                255
Asn Ile Thr Thr Cys His Asp Val Leu Asn Glu Thr Leu Leu His Gly 
             260                265                270
Phe Tyr Ser Tyr Tyr Phe Ser Ala Phe Ser Ala Ile Phe Phe Leu Val 
         275                280                285
Pro Leu Ile Ile Ser Thr Val Cys Tyr Thr Ser Ile Ile Arg Cys Leu 
     290                295                300
Ser Ser Ser Ala Val Ala Asn Arg Ser Lys Lys Ser Arg Ala Leu Phe 
 305                310                315                320
Leu Ser Ala Ala Val Phe Cys Ile Phe Ile Val Cys Phe Gly Pro Thr 
                 325                330                335
Asn Val Leu Leu Ile Val His Tyr Leu Leu Leu Ser Asp Ser Pro Gly 
             340                345                350
Thr Glu Thr Ala Tyr Phe Ala Tyr Leu Leu Cys Val Cys Val Thr Ser 
         355                360                365
Val Ala Ser Cys Ile Asp Pro Leu Ile Tyr Tyr Tyr Ala Ser Ser Glu 
     370                375                380
Cys Gln Lys His Leu Tyr Ser Ile Leu Cys Cys Arg Glu Ser Ser Asp 
 385                390                395                400
Ser Asn Ser Cys Asn Ser Thr Gly Gln Leu Met Pro Ser Lys Met Asp 
                 405                410                415
Thr Cys Ser Ser His Leu Asn Asn Ser Ile Tyr Lys Lys Leu Leu Ala 
             420                425                430



<210> 3943
<211> 3472
<212> DNA
<213> Homo sapiens
<308> M62424
<400> 3943

gcgcccgcg  gaccgcgcg  cccagtccc  ccccgcccc  ctaaccgcc  cagacacag  60
gctcgccga  ggtcgcttg  accctgatc  tacccgtgg  caccctgcg  tctgcctgc  120
gcgaagacc  gctccccga  ccgcagaag  caggagaga  ggtgaagcg  agcagcccg  180
ggcggggca  cctcccgga  cagcgccgc  cagagcccg  gacaatggg  ccgcggcgg  240
tgctgctgg  ggccgcctg  ttcagtctg  gcggcccgc  gttgtctgc  cgcacccgg  300
cccgcaggc  agaatcaaa  gcaacaaat  ccaccttag  tccccggtc  tttcttctc  360
ggaacccca  tgataaata  gaaccattt  gggaggatg  ggagaaaaa  gaaagtggg  420
taactgaat  cagattagt  tccatcaat  aaagcagtc  tcttcaaaa  caacttcct  480
cattcatct  agaagatgc  tccggatat  tgaccagct  ctggctgac  ctctttgtc  540
catctgtgt  caccggagt  tttgtagtc  gcctcccac  aaacatcat  gccatcgtt  600
tgttcatcc  gaaaatgaa  gtcaagaag  cggcggtgg  gtacatgct  cacctggcc  660
cggcagatg  gctgtttgt  tctgtgctc  cctttaaga  cagctatta  ttttccggc  720
gtgattggc  gtttgggtc  gaattgtgt  gcttcgtca  tgcagcatt  tactgtaac  780
tgtacgcct  tatcttgct  atgacagtc  taagcattg  ccggtttct  gctgtggtg  840
atcccatgc  gtccctctc  tggcgtact  tgggaaggg  ttccttcac  tgtctggcc  900
tctgggctt  ggccatcgc  ggggtagtg  ctctcgtcc  caaggagca  accatccag  960
tgcccgggc  caacatcac  acctgtcat  atgtgctca  tgaaaccct  ctcgaaggc  1020
actatgcct  ctacttctc  gccttctct  ctgtcttct  ttttgtgcc  ctgatcatt  1080
ccacggtct  ttatgtgtc  atcattcga  gtcttagct  ttccgcagt  gccaaccgc  1140
gcaagaagt  ccgggcttt  ttcctgtca  ctgctgttt  ctgcatctt  atcatttgc  1200
tcggaccca  aaacgtcct  ctgattgcg  attactcat  cctttctca  acttccacc  1260
cagaggctg  ctactttgc  tacctcctc  gtgtctgtg  cagcagcat  agctcgtgc  1320
tcgaccccc  aatttacta  tacgcttcc  ctgagtgcc  gaggtacgt  tacagtatc  1380
tatgctgca  agaaagttc  gatcccagc  gttataaca  cagtgggca  ttgatggca  1440
gtaaaatgg  tacctgctc  agtaacctg  ataacagca  atacaaaaa  ctgttaact  1500
aggaaaagg  actgctggg  ggttaaaaa  aaaagttta  aaaagtgaa  aacctgagg  1560
ttctattag  ccccaccca  actttattg  ttcacctcc  aaaacaaca  atgtacgac  1620
tgcatacct  ctttttatg  gagctgtca  gcatgtatt  ttgtcaatt  ccagaaaga  1680
aacaggacg  gatgacggt  ttattccaa  ggaatattg  caatgctac  gtaataaat  1740
aatgtcact  ctggatata  ctaggtgac  tatacatac  tacatgtgt  tatatgtag  1800
tgtatgcac  cacatatat  atttgcagt  cagtataga  taggcactt  aaaacactc  1860
ttccccgca  cccagcaat  atgaaaata  tctctgatt  cctgattta  tatgcaaag  1920
ctaggttgg  agagtttag  cctgaacat  tcatggtgt  catcaacag  gagagactc  1980
atagtttgg  cttgtacca  ttttgcaaa  aagtgtatt  tgaaattgt  tgacggcaa  2040
gtttaagtt  ttaagaggt  agacttagt  ctatctgtg  gtagaagtt  tagtgtttt  2100
aattttaaa  atatccaag  ttgaattcc  aaaattatg  aaacagatg  aaagcctct  2160
ttttgatat  ggtagtatt  tttacattt  acacactgt  cacataagc  aaaactgag  2220
ataagtcct  tagtgaatg  aggctggct  tcagagtag  ctattcctg  gagctgcat  2280
tgtccgccc  cgatggagg  ctccaggca  cagacacat  ccagggcca  gtcagacac  2340
gattggcca  aaaccttcc  gctgagcct  acagcagtg  gactggggc  actacattt  2400
ctccatcct  ctgggattg  ctgtgaact  atcatgttt  tgagaaact  gcaaagcag  2460
atgtgatat  ctaggaggt  atgaccatg  aagacttct  tacccatct  aaaaacaac  2520
aaagaaggc  tggacttct  gatgcccat  cactgggtg  aaacacatc  agtagttgt  2580
ctgaaatgt  agttctgat  tggaagcac  cattatgcg  tgtggccac  ccaataggt  2640
ctgagtgta  agagtggaa  aagacagag  cctgccctc  agagcaaag  agatcatgc  2700
tagagtgtg  tgtatgtgt  ataaatatg  ttcacacaa  caaggcctg  cagctaaag  2760
agtttgaac  tttgggtta  tatttcttg  ggttataac  taatgaaaa  aatgcagta  2820
aggacatat  ttttttaaa  taagtctga  ttaattggg  actatttat  tacaaatgt  2880
ttgctcaat  gattgctca  atcaggttt  cttttaaga  tcaatcatg  cagtctgct  2940
agaaataac  gaagaaaat  gaattgaca  tgaaatcta  gaaaattat  ctataattt  3000
catttactt  agacttaat  agactttaa  agcattttt  aacctccta  gtatcaagt  3060
tagaaaatc  tcatggaat  cacaaagta  tttggaaat  aggttgaaa  atatctctt  3120
tcttacgaa  aaatggtag  attttaaac  aaatagaaa  ttgcaaggc  aatgtttat  3180
taaaagagc  ggccaggcg  ggtggctca  gcctgtaat  ccagcactt  gggaggctg  3240
ggcgggtgg  tcacgaggt  aggagatcg  gaccatcct  gctaacacg  tgaaacccg  3300
ctctactaa  aatgcaaaa  aaattagcc  ggcgtggtg  caggcacct  tagtcccag  3360
tactcggga  gctgaggca  gagactggc  tgaacccag  aggcggacc  tgtagtgag  3420
cgagatcgc  ccactgtgc  ccagcctgg  caacagagc  agactccat  tc  3472



<210> 3944
<211> 425
<212> PRT
<213> Homo sapiens
<308> P25116
<400> 3944

Met Gly Pro Arg Arg Leu Leu Leu Val Ala Ala Cys Phe Ser Leu Cys 
  1               5                  10                  15
Gly Pro Leu Leu Ser Ala Arg Thr Arg Ala Arg Arg Pro Glu Ser Lys 
             20                  25                  30
Ala Thr Asn Ala Thr Leu Asp Pro Arg Ser Phe Leu Leu Arg Asn Pro 
         35                  40                  45
Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp Glu Glu Lys Asn Glu Ser 
     50                  55                  60
Gly Leu Thr Glu Tyr Arg Leu Val Ser Ile Asn Lys Ser Ser Pro Leu 
 65                  70                  75                  80
Gln Lys Gln Leu Pro Ala Phe Ile Ser Glu Asp Ala Ser Gly Tyr Leu 
                 85                  90                  95
Thr Ser Ser Trp Leu Thr Leu Phe Val Pro Ser Val Tyr Thr Gly Val 
             100                105                110
Phe Val Val Ser Leu Pro Leu Asn Ile Met Ala Ile Val Val Phe Ile 
         115                120                125
Leu Lys Met Lys Val Lys Lys Pro Ala Val Val Tyr Met Leu His Leu 
     130                135                140
Ala Thr Ala Asp Val Leu Phe Val Ser Val Leu Pro Phe Lys Ile Ser 
 145                150                155                160
Tyr Tyr Phe Ser Gly Ser Asp Trp Gln Phe Gly Ser Glu Leu Cys Arg 
                 165                170                175
Phe Val Thr Ala Ala Phe Tyr Cys Asn Met Tyr Ala Ser Ile Leu Leu 
             180                185                190
Met Thr Val Ile Ser Ile Asp Arg Phe Leu Ala Val Val Tyr Pro Met 
         195                200                205
Gln Ser Leu Ser Trp Arg Thr Leu Gly Arg Ala Ser Phe Thr Cys Leu 
     210                215                220
Ala Ile Trp Ala Leu Ala Ile Ala Gly Val Val Pro Leu Leu Leu Lys 
 225                230                235                240
Glu Gln Thr Ile Gln Val Pro Gly Leu Asn Ile Thr Thr Cys His Asp 
                 245                250                255
Val Leu Asn Glu Thr Leu Leu Glu Gly Tyr Tyr Ala Tyr Tyr Phe Ser 
             260                265                270
Ala Phe Ser Ala Val Phe Phe Phe Val Pro Leu Ile Ile Ser Thr Val 
         275                280                285
Cys Tyr Val Ser Ile Ile Arg Cys Leu Ser Ser Ser Ala Val Ala Asn 
     290                295                300
Arg Ser Lys Lys Ser Arg Ala Leu Phe Leu Ser Ala Ala Val Phe Cys 
 305                310                315                320
Ile Phe Ile Ile Cys Phe Gly Pro Thr Asn Val Leu Leu Ile Ala His 
                 325                330                335
Tyr Ser Phe Leu Ser His Thr Ser Thr Thr Glu Ala Ala Tyr Phe Ala 
             340                345                350
Tyr Leu Leu Cys Val Cys Val Ser Ser Ile Ser Cys Cys Ile Asp Pro 
         355                360                365
Leu Ile Tyr Tyr Tyr Ala Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser 
     370                375                380
Ile Leu Cys Cys Lys Glu Ser Ser Asp Pro Ser Ser Tyr Asn Ser Ser 
 385                390                395                400
Gly Gln Leu Met Ala Ser Lys Met Asp Thr Cys Ser Ser Asn Leu Asn 
                 405                410                415
Asn Ser Ile Tyr Lys Lys Leu Leu Thr 
             420                425



<210> 3945
<211> 2153
<212> DNA
<213> Rattus norvegicus
<308> M81687
<400> 3945

cgtcccctc  gttctgcat  cccaaactt  agccgcagc  ctgtttcaa  ccatcggct  60
cttgcttca  atcagacag  accgcgacc  agacacccg  gtccgcgga  tgaaagcac  120
acgccgagt  ggaccagac  aggaaaata  actcgtgaa  cagcaactc  ggattggga  180
ggcagaagc  aacaagtga  aaggcgcgg  gtttccggg  cgctgtgcg  aagctagag  240
aggcgccag  gaagacagc  cgagctcag  acccgagac  aagcctctc  cccggaggc  300
gctcagctc  tatcttctc  aggcccgct  cagcgtgcg  tgggcttcg  tttatgcgg  360
tacgagcca  gtccccggg  aatatgcag  gtgcgtgga  cctgctcac  ttgggcttg  420
tggcctgtg  gtcggcaga  acgagagca  agctgacat  tgataagga  atgtacctt  480
acagcagct  cattgagga  gcttcagga  tatatccta  tgatgatga  gactattct  540
ctgcctctg  ctcaggagc  tatgaagac  aagggagtc  agatctgac  acatcccaa  600
tgattccaa  gatctccct  actagtgct  ctcccgaag  ggaaaccat  acgttgaag  660
cacaaagca  cacacccac  cagaccgag  cacccgaag  aactgacaa  aaggagttt  720
aaatctctg  ggcagaaga  aagcaggac  ctgctgtaa  aagcacaga  gtgtacacc  780
agaaacatt  agacaatct  ttcaagcgg  cggaagttc  agcagctgt  attgctggc  840
gtgtgattg  ctttctctt  gccattttc  tcatcctgt  gttggtgta  cgcatgcgg  900
agaaagacg  aggaagcta  gaccttgga  aacgcaaac  gtccagcgc  gcttaccag  960
aggcaccca  taaggagtt  tatgcataa  actcccact  agtgtctct  tttaagaga  1020
cactgaact  ttcaaaata  agctttagc  tagaataat  aatatcttt  ttatctgtt  1080
tgttcatta  agagccatg  tggcccttt  atgatgaag  tcccattgt  tttaaaatt  1140
ttcatatat  tctttagaa  gacttaaaa  taaaaattt  acatctgca  tgttctgtg  1200
atagcagtg  caaaatatt  tgttacaaa  acccttgac  ttcatggaa  tgatttgaa  1260
atctatgtg  aaatacaaa  tgattgtgt  tgtcctctg  ttcaaagat  actgctgtt  1320
ccctcatca  cagatctcc  gttgacctt  ccgagttga  ctttgttaa  ttatctctt  1380
ttcctcttc  ctgccctcc  ttcttgtct  ctcccttaa  aacaaaacc  tatgccttt  1440
gtagctgtc  tggtgcaat  tgtctttga  tgattacaa  aatggtaat  tagtgtata  1500
gtgattttt  tcaattatg  aaactttaa  ctcctcttt  tgtaatttt  ttaaatgtc  1560
gactaccca  tttacactt  ctttaattt  cattccctg  agcttcagg  agatttgca  1620
aggcaaatt  taaaattgg  ttattacta  gaaactgtt  gtcctagtt  tctaagcag  1680
cttctcttg  aggatttga  atcactgac  agcctcagc  aacccaaag  tgctaacag  1740
atttgagaa  ttgctacag  ctcctttgg  cactgtact  gctagttta  aatttgaag  1800
tacaaggaa  agtttaaag  aaaaaaaag  tcagttttt  ttcttaaaa  tgcatttaa  1860
ttgtaaaca  ctttttaag  ctttgaagt  cctatgatt  tatgtaact  gttgcagac  1920
ggtgttaat  agtatatat  acagttttt  aaaagttgg  attttataa  cacagacaa  1980
tctaatggt  acttttgta  tcttatgaa  agacataaa  tgtaatttg  gaacaagca  2040
actactgaa  aaatcacat  gcctaatat  gaaaatgtc  ctgttataa  tttgtacat  2100
tcttatcaa  tgtacagct  ccctttgct  tgactgact  tctgttctc  gtg  2153



<210> 3946
<211> 201
<212> PRT
<213> Rattus norvegicus
<308> P34900
<400> 3946

Met Gln Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Met Ala Cys Val 
  1               5                  10                  15
Ser Ala Glu Thr Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
             20                  25                  30
Asp Ser Ser Ser Ile Glu Glu Ala Ser Gly Leu Tyr Pro Ile Asp Asp 
         35                  40                  45
Asp Asp Tyr Ser Ser Ala Ser Gly Ser Gly Ala Tyr Glu Asp Lys Gly 
     50                  55                  60
Ser Pro Asp Leu Thr Thr Ser Gln Leu Ile Pro Arg Ile Ser Leu Thr 
 65                  70                  75                  80
Ser Ala Ala Pro Glu Val Glu Thr Met Thr Leu Lys Thr Gln Ser Ile 
                 85                  90                  95
Thr Pro Thr Gln Thr Glu Ser Pro Glu Glu Thr Asp Lys Lys Glu Phe 
             100                105                110
Glu Ile Ser Glu Ala Glu Glu Lys Gln Asp Pro Ala Val Lys Ser Thr 
         115                120                125
Asp Val Tyr Thr Glu Lys His Ser Asp Asn Leu Phe Lys Arg Thr Glu 
     130                135                140
Val Leu Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe Ala 
 145                150                155                160
Ile Phe Leu Ile Leu Leu Leu Val Tyr Arg Met Arg Lys Lys Asp Glu 
                 165                170                175
Gly Ser Tyr Asp Leu Gly Glu Arg Lys Pro Ser Ser Ala Ala Tyr Gln 
             180                185                190
Lys Ala Pro Thr Lys Glu Phe Tyr Ala 
         195                200



<210> 3947
<211> 463
<212> DNA
<213> Homo sapiens
<308> AI373958
<400> 3947

ttttttttt  ttttttttt  acttttggc  tgacagact  tattttggc  ctttcacaa  60
tattttgct  tacagcagg  acaaaatat  tgccagaaa  ttttctttt  ctggcacgg  120
tattcccag  agttgttat  ctatgaatt  aatttcact  tgctttgca  agttagagg  180
atacccatt  ctaccctct  taattgagg  acacagcgt  gctttagaa  gctaggcta  240
cgtttcctt  tagtcactc  aaagtgaat  ggttctgta  gtgatgggg  aggaatctg  300
gaattaatt  aggccatta  ggatttaaa  taaacactg  tccaagtgt  gcttaaaaa  360
atgttttta  tgaattatg  ggcaattcc  gggaatgtt  tcaaaatga  atattcata  420
tttattaaa  gtaaatngg  tgtgggaaa  gnngctttt  ttg  463



<210> 3948
<211> 201
<212> PRT
<213> Homo sapiens
<308> P34741
<400> 3948

Met Arg Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Val Ala Cys Val 
  1               5                  10                  15
Ser Ala Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
             20                  25                  30
Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
         35                  40                  45
Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu 
     50                  55                  60
Ser Pro Glu Leu Thr Thr Thr Arg Pro Leu Pro Lys Ile Leu Leu Thr 
 65                  70                  75                  80
Ser Ala Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys 
                 85                  90                  95
Ile Pro Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val 
             100                105                110
His Leu Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr 
         115                120                125
Asn Val Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu 
     130                135                140
Val Leu Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe Ala 
 145                150                155                160
Ile Phe Leu Ile Leu Leu Leu Val Tyr Arg Met Arg Lys Lys Asp Glu 
                 165                170                175
Gly Ser Tyr Asp Leu Gly Glu Arg Lys Pro Ser Ser Ala Ala Tyr Gln 
             180                185                190
Lys Ala Pro Thr Lys Glu Phe Tyr Ala 
         195                200



<210> 3949
<211> 1163
<212> DNA
<213> Rattus norvegicus
<308> M82826
<400> 3949

tttatggaa  ttctgacaa  aatccttca  caaggaaca  aatttgata  acttgctga  60
accgtgttg  cagatcggt  cgagagact  gtggaactg  tcacaatga  gggagacca  120
ggagagctc  ctatagcta  ggctctggc  aatgtggtc  cttgttctc  gtgggatga  180
ctggctcga  ttctggtca  gctgtttga  tctcggcat  tgctctacc  gctgctctg  240
aacatgttt  ctaaggagg  agagttggc  gactccatg  agactctct  tcgaggcaa  300
agcttggcc  gtaagataa  gacgttctg  ttcaaggtg  acggtgcta  ttacctaca  360
aagctcttg  accccttgt  acgaatcat  atcacatcc  ccgattggc  gcatgttag  420
tttgaagtg  atcctacca  gttagagcc  tctgagagc  ttgaggaga  ccagaggaa  480
ctccttcag  tgacagaga  gttcttcca  gccatcatc  gttcttcct  agagttccc  540
tcgcagctt  gaagtgtct  ccattgttt  taccaggca  cttgccact  cctactgaa  600
aaagctaca  taaaagaaa  aaaggaaaa  aaaaaatca  ttcctgaga  ttcctgttt  660
tcctgtggt  taaataata  gtggttagc  agcgcttcc  tcagaacag  atcggtgcc  720
tcggaagtg  catgttcct  aggttcatc  accctgcca  tgtctcacc  tatgaagca  780
ggattttag  taaaaagcc  ccacctaga  ttgaaaggg  cttgaagtt  atgtcaaag  840
tccttcaga  cattgccaa  catgtactg  tcacaaagg  agagcacat  aggcctttt  900
atgattttg  gaaaagcaa  tccgacttg  cacggaggt  tttcttaga  atagcatca  960
attgtccca  aagtgacgc  gtaaaccat  gtctttcct  catcagtga  ggcaatgtg  1020
ttgctttac  tcggctgct  tggaataat  aggagaaaa  tggccagta  ctttccagc  1080
acagggatc  taaagctgt  ggaagacga  ctttcgata  gatggccac  cttcttgca  1140
atctgggtc  tccggagca  aag  1163



<210> 3950
<211> 246
<212> PRT
<213> Rattus norvegicus
<308> AAA41691
<400> 3950

Phe Met Glu Val Leu Thr Lys Ile Leu Gln Gln Gly Thr Glu Phe Asp 
  1               5                  10                  15
Thr Leu Ala Glu Thr Val Leu Ala Asp Arg Phe Glu Arg Leu Val Glu 
             20                  25                  30
Leu Val Thr Met Met Gly Asp Gln Gly Glu Leu Pro Ile Ala Met Ala 
         35                  40                  45
Leu Ala Asn Val Val Pro Cys Ser Gln Trp Asp Glu Leu Ala Arg Val 
     50                  55                  60
Leu Val Thr Leu Phe Asp Ser Arg His Leu Leu Tyr Gln Leu Leu Trp 
 65                  70                  75                  80
Asn Met Phe Ser Lys Glu Val Glu Leu Ala Asp Ser Met Gln Thr Leu 
                 85                  90                  95
Phe Arg Gly Asn Ser Leu Ala Ser Lys Ile Met Thr Phe Cys Phe Lys 
             100                105                110
Val Tyr Gly Ala Thr Tyr Leu Gln Lys Leu Leu Asp Pro Leu Leu Arg 
         115                120                125
Ile Ile Ile Thr Ser Ser Asp Trp Gln His Val Ser Phe Glu Val Asp 
     130                135                140
Pro Thr Arg Leu Glu Pro Ser Glu Ser Leu Glu Glu Asn Gln Arg Asn 
 145                150                155                160
Leu Leu Gln Met Thr Glu Lys Phe Phe His Ala Ile Ile Ser Ser Ser 
                 165                170                175
Ser Glu Phe Pro Ser Gln Leu Arg Ser Val Cys His Cys Leu Tyr Gln 
             180                185                190
Ala Thr Cys His Ser Leu Leu Asn Lys Ala Thr Val Lys Glu Lys Lys 
         195                200                205
Glu Asn Lys Lys Ser Val Pro Glu Ser Ser Cys Phe Ser Cys Gly Leu 
     210                215                220
Asn Asn Arg Trp Leu Ala Ser Ala Ser Leu Arg Thr Ala Ser Val Pro 
 225                230                235                240
Ser Glu Val Pro Cys Ser 
                 245



<210> 3951
<211> 1163
<212> DNA
<213> Rattus norvegicus
<308> M82826
<400> 3951

tttatggaa  ttctgacaa  aatccttca  caaggaaca  aatttgata  acttgctga  60
accgtgttg  cagatcggt  cgagagact  gtggaactg  tcacaatga  gggagacca  120
ggagagctc  ctatagcta  ggctctggc  aatgtggtc  cttgttctc  gtgggatga  180
ctggctcga  ttctggtca  gctgtttga  tctcggcat  tgctctacc  gctgctctg  240
aacatgttt  ctaaggagg  agagttggc  gactccatg  agactctct  tcgaggcaa  300
agcttggcc  gtaagataa  gacgttctg  ttcaaggtg  acggtgcta  ttacctaca  360
aagctcttg  accccttgt  acgaatcat  atcacatcc  ccgattggc  gcatgttag  420
tttgaagtg  atcctacca  gttagagcc  tctgagagc  ttgaggaga  ccagaggaa  480
ctccttcag  tgacagaga  gttcttcca  gccatcatc  gttcttcct  agagttccc  540
tcgcagctt  gaagtgtct  ccattgttt  taccaggca  cttgccact  cctactgaa  600
aaagctaca  taaaagaaa  aaaggaaaa  aaaaaatca  ttcctgaga  ttcctgttt  660
tcctgtggt  taaataata  gtggttagc  agcgcttcc  tcagaacag  atcggtgcc  720
tcggaagtg  catgttcct  aggttcatc  accctgcca  tgtctcacc  tatgaagca  780
ggattttag  taaaaagcc  ccacctaga  ttgaaaggg  cttgaagtt  atgtcaaag  840
tccttcaga  cattgccaa  catgtactg  tcacaaagg  agagcacat  aggcctttt  900
atgattttg  gaaaagcaa  tccgacttg  cacggaggt  tttcttaga  atagcatca  960
attgtccca  aagtgacgc  gtaaaccat  gtctttcct  catcagtga  ggcaatgtg  1020
ttgctttac  tcggctgct  tggaataat  aggagaaaa  tggccagta  ctttccagc  1080
acagggatc  taaagctgt  ggaagacga  ctttcgata  gatggccac  cttcttgca  1140
atctgggtc  tccggagca  aag  1163



<210> 3952
<211> 246
<212> PRT
<213> Rattus norvegicus
<308> AAA41691
<400> 3952

Phe Met Glu Val Leu Thr Lys Ile Leu Gln Gln Gly Thr Glu Phe Asp 
  1               5                  10                  15
Thr Leu Ala Glu Thr Val Leu Ala Asp Arg Phe Glu Arg Leu Val Glu 
             20                  25                  30
Leu Val Thr Met Met Gly Asp Gln Gly Glu Leu Pro Ile Ala Met Ala 
         35                  40                  45
Leu Ala Asn Val Val Pro Cys Ser Gln Trp Asp Glu Leu Ala Arg Val 
     50                  55                  60
Leu Val Thr Leu Phe Asp Ser Arg His Leu Leu Tyr Gln Leu Leu Trp 
 65                  70                  75                  80
Asn Met Phe Ser Lys Glu Val Glu Leu Ala Asp Ser Met Gln Thr Leu 
                 85                  90                  95
Phe Arg Gly Asn Ser Leu Ala Ser Lys Ile Met Thr Phe Cys Phe Lys 
             100                105                110
Val Tyr Gly Ala Thr Tyr Leu Gln Lys Leu Leu Asp Pro Leu Leu Arg 
         115                120                125
Ile Ile Ile Thr Ser Ser Asp Trp Gln His Val Ser Phe Glu Val Asp 
     130                135                140
Pro Thr Arg Leu Glu Pro Ser Glu Ser Leu Glu Glu Asn Gln Arg Asn 
 145                150                155                160
Leu Leu Gln Met Thr Glu Lys Phe Phe His Ala Ile Ile Ser Ser Ser 
                 165                170                175
Ser Glu Phe Pro Ser Gln Leu Arg Ser Val Cys His Cys Leu Tyr Gln 
             180                185                190
Ala Thr Cys His Ser Leu Leu Asn Lys Ala Thr Val Lys Glu Lys Lys 
         195                200                205
Glu Asn Lys Lys Ser Val Pro Glu Ser Ser Cys Phe Ser Cys Gly Leu 
     210                215                220
Asn Asn Arg Trp Leu Ala Ser Ala Ser Leu Arg Thr Ala Ser Val Pro 
 225                230                235                240
Ser Glu Val Pro Cys Ser 
                 245



<210> 3953
<211> 1186
<212> DNA
<213> Rattus norvegicus
<308> M83107
<400> 3953

agggcgggt  ctcaggcac  ttcactggc  tggatccct  ggggtacag  ctgttcacc  60
acttgctca  aatcacgcc  ttcttcagc  acacctgga  gcccagaca  caacgctac  120
ctccttcca  cccacaaac  accaagcct  ttctgcctc  acatggcca  caagggtcc  180
tcctatggc  tgagccgtg  agtgcagtc  aagattgag  agaagtatg  tgaggagct  240
gaggagcgg  tagtggagt  gattgtaat  cagtgtggc  ctgatgtgg  ccgtccaga  300
cgtgggcgc  tgggcttcc  ggtgtggct  aagaatggc  tgattctga  caagttggt  360
aacagcctg  accccgagg  atccaagcc  gtgaaggtg  ctgagaacc  gccctccat  420
gtcttcaag  agatggaac  ggtggctca  ttcttgaag  cagctgagg  ttatggagt  480
acgaagact  acatgttcc  gactgttga  ctctttgaa  gaaaagata  ggcagcagt  540
cagaggact  taatggctt  gggcagttt  gccgtgacc  agaacgatg  acactaccg  600
ggagatccc  actggttta  gaagaaagc  caggagcat  agagggagt  cacagacag  660
caactgcag  aggggaagc  cgtcattgg  cttcaaatg  gcagcaaca  aggggcctc  720
caggctggc  tgacaggct  tgggcgacc  cggcagatc  tcagttaga  agggaaggc  780
agctctgag  tgcagcatc  tgcttagcc  gcctcaccc  cgcctatat  ggttcttag  840
ccggacagc  ttgaggtat  actgggcaa  gatgactgc  catgggcag  tcccaccta  900
cctcagcct  agccccgct  cttacccca  agccaccac  gtcctggcc  ctgttccca  960
ctgtccccc  acctctacc  tttccccca  cctggagta  gcagggaga  gtgggctga  1020
gtagcctga  tgtaggcca  cccactgtc  ttggaagcc  atgtccttt  aaagagacc  1080
tgcctctac  tctttttct  gaatatttt  tgggttgaa  ttcaaaaag  aaaaaaata  1140
atacatata  atatatctc  aaaaaaaat  aaaaaaaaa  aaaaaa  1186



<210> 3954
<211> 200
<212> PRT
<213> Rattus norvegicus
<308> P31232
<400> 3954

Ala Asn Lys Gly Pro Ser Tyr Gly Met Ser Arg Glu Val Gln Ser Lys 
  1               5                  10                  15
Ile Glu Lys Lys Tyr Asp Glu Glu Leu Glu Glu Arg Leu Val Glu Trp 
             20                  25                  30
Ile Val Met Gln Cys Gly Pro Asp Val Gly Arg Pro Asp Arg Gly Arg 
         35                  40                  45
Leu Gly Phe Gln Val Trp Leu Lys Asn Gly Val Ile Leu Ser Lys Leu 
     50                  55                  60
Val Asn Ser Leu Tyr Pro Glu Gly Ser Lys Pro Val Lys Val Pro Glu 
 65                  70                  75                  80
Asn Pro Pro Ser Met Val Phe Lys Gln Met Glu Gln Val Ala Gln Phe 
                 85                  90                  95
Leu Lys Ala Ala Glu Asp Tyr Gly Val Thr Lys Thr Asp Met Phe Gln 
             100                105                110
Thr Val Asp Leu Phe Glu Gly Lys Asp Met Ala Ala Val Gln Arg Thr 
         115                120                125
Val Met Ala Leu Gly Ser Leu Ala Val Thr Lys Asn Asp Gly His Tyr 
     130                135                140
Arg Gly Asp Pro Asn Trp Phe Met Lys Lys Ala Gln Glu His Lys Arg 
 145                150                155                160
Glu Phe Thr Asp Ser Gln Leu Gln Glu Gly Lys His Val Ile Gly Leu 
                 165                170                175
Gln Met Gly Ser Asn Arg Gly Ala Ser Gln Ala Gly Met Thr Gly Tyr 
             180                185                190
Gly Arg Pro Arg Gln Ile Ile Ser 
         195                200



<210> 3955
<211> 1082
<212> DNA
<213> Homo sapiens
<308> XM_006432
<400> 3955

atcctgtct  tccgaaccc  gacacaagt  ttcactcct  cctgcgagc  ctgaggaag  60
cttctttcc  cagacatgg  caacaaggg  ccttcctat  gcatgagcc  cgaagtgca  120
tccaaaatc  agaagaagt  tgacgagga  ctggaggag  ggctggtgg  gtggatcat  180
gtgcagtgt  gccctgatg  gggccgccc  gaccgtggg  gcttgggct  ccaggtctg  240
ctgaagaat  gcgtgattc  gagcaagct  gtgaacagc  tgtaccctg  tggctccaa  300
ccggtgaag  tgcccgaga  cccaccctc  atggtcttc  agcagatgg  gcaggtggc  360
cagttcctg  aggcggctg  ggactatgg  gtcatcaag  ctgacatgt  ccagactgt  420
gacctcttt  aaggcaaag  catggcagc  gtgcagagg  ccctgatgg  tttgggcag  480
ttggcagtg  ccaagaatg  tgggcacta  cgtggagat  ccaactggt  tatgaagaa  540
gcgcaggag  ataagaggg  attcacaga  agccagctg  aggagggaa  gcatgtcat  600
ggccttcag  tgggcagca  cagaggggc  tcccaggcc  gcatgacag  ctacggacg  660
cctcggcag  tcatcagtt  gagcggaga  ggctagccc  gagcccggc  ctcccccag  720
tccttggct  cagccatcc  gcttagcct  cctcaccca  acccgtgtg  taccttcag  780
cctggccaa  ctttgaggc  ctgtcactg  gcaatggta  ctgcacctg  gcagctcct  840
cctgtgccc  cagcctcag  ccaacttct  acccgaaag  atcactgcc  tggcccctc  900
ctcccggct  cccccatca  ctctactgt  tcctccctg  gctaagcag  ggagaagcg  960
gctgggggt  gcctggatg  gggccaagt  cactgtcct  cttggcggc  aaagcccat  1020
gaagaagaa  cagcccagc  tgcccccta  cttgtcctg  aatattttt  gggttggaa  1080
tc  1082



<210> 3956
<211> 201
<212> PRT
<213> Homo sapiens
<308> XP_006432
<400> 3956

Met Ala Asn Lys Gly Pro Ser Tyr Gly Met Ser Arg Glu Val Gln Ser 
  1               5                  10                  15
Lys Ile Glu Lys Lys Tyr Asp Glu Glu Leu Glu Glu Arg Leu Val Glu 
             20                  25                  30
Trp Ile Ile Val Gln Cys Gly Pro Asp Val Gly Arg Pro Asp Arg Gly 
         35                  40                  45
Arg Leu Gly Phe Gln Val Trp Leu Lys Asn Gly Val Ile Leu Ser Lys 
     50                  55                  60
Leu Val Asn Ser Leu Tyr Pro Asp Gly Ser Lys Pro Val Lys Val Pro 
 65                  70                  75                  80
Glu Asn Pro Pro Ser Met Val Phe Lys Gln Met Glu Gln Val Ala Gln 
                 85                  90                  95
Phe Leu Lys Ala Ala Glu Asp Tyr Gly Val Ile Lys Thr Asp Met Phe 
             100                105                110
Gln Thr Val Asp Leu Phe Glu Gly Lys Asp Met Ala Ala Val Gln Arg 
         115                120                125
Thr Leu Met Ala Leu Gly Ser Leu Ala Val Thr Lys Asn Asp Gly His 
     130                135                140
Tyr Arg Gly Asp Pro Asn Trp Phe Met Lys Lys Ala Gln Glu His Lys 
 145                150                155                160
Arg Glu Phe Thr Glu Ser Gln Leu Gln Glu Gly Lys His Val Ile Gly 
                 165                170                175
Leu Gln Met Gly Ser Asn Arg Gly Ala Ser Gln Ala Gly Met Thr Gly 
             180                185                190
Tyr Gly Arg Pro Arg Gln Ile Ile Ser 
         195                200



<210> 3957
<211> 2142
<212> DNA
<213> Rattus norvegicus
<308> M83298
<400> 3957

ggggccgcc  tcgctgtcc  agccgccgc  gctgccgcc  ccgccgctg  cgtcttcac  60
gcgggagaa  gagcacgag  caggacgcc  ctgagtgaa  gccaccatc  tgccgacag  120
tccgcccgg  ctgcttcct  tccgcccag  tccccgtcc  ctcccccct  aggtgccat  180
cgcctccat  cgcgccctc  atcccccca  ccccaggtg  gggggctga  ccccggtcg  240
ggaggcccg  acgagcccg  cagggtcac  atttgcagc  cgacatggc  ggagctgga  300
gagggaatg  tattcaatg  tgtttttct  aggtgaaag  agcagttga  gatgacgta  360
cagaagcag  tataatttc  acagtagag  ttaatcatt  tggagaatt  ctagccaca  420
gagataaag  tgggagagt  gtcatcttt  aacaagagc  ggagaacaa  atccagtct  480
atagcagag  agaatacaa  gtttacagc  ccttccaga  ccatgagcc  gaatttgac  540
acttgaaaa  cttagaaat  gaagagaag  tcaacaaaa  taggtggtt  ccccagaaa  600
atgctgccc  gtttttatt  tctaccaat  ataaaacaa  aaaattatg  aaaatcagt  660
aaagagaca  aagaccaga  ggctataac  tgaaagagg  agatggaag  tatagagac  720
ctactacag  cactacact  cgagtgccg  tgtttaggc  catggatct  atggtggag  780
ccagtccgc  gagaatatt  gccaacgcc  atacctacc  catcaactc  atttctatc  840
atagtgatt  tgaaaccta  ttatcagca  atgatttgc  aattaatct  tggcatctg  900
aaattacag  caggagttt  aatattgtg  acattaagc  tgccaatat  gaggagctc  960
cggaggtga  cacagccgc  gagttccat  ccaacagct  taacacgtt  gtgtacagc  1020
gcagtaaag  gaccattcg  ttatgtgac  tgagggcat  tgcactctg  gacaggcat  1080
ctaaactgt  tgaagaacc  gaagatccc  gcaacaggt  gtttttttc  gaaatcatc  1140
cctcaattt  tgatgtaaa  ttcagccac  gtggtcgct  tatgatgac  agagactat  1200
tgtcagtca  agtttggga  ttgaatatg  aaaacaggc  cgtggagac  taccaggta  1260
acgaatacc  cagaagtaa  ctttgctca  tgtatgaaa  cgactgcat  tttgacaaa  1320
ttgaatgtt  ttggaatgg  tctgacagt  ttgtcatga  tggatccta  aataatttc  1380
tcagaatgt  cgacaggaa  acaaagcgg  atataactc  agaagcatc  cgagaaaac  1440
ataagcctc  tacagtttt  aaaccacgc  aagtctgtg  aagtggcaa  cgaaagaaa  1500
atgaaataa  tgttgacag  ctagacttc  acaagaaaa  ccttcatac  gcctggcat  1560
ccaaggaaa  catcattgc  gtagcgact  caaacaatc  gtatatatt  caagacaaa  1620
tgaattagg  tggcattct  tgcagagga  ccacttcct  cttagtgag  tagttgaat  1680
tagcattcg  acctataag  gagcggtcc  ttgtggcgt  cctttccag  gtttgacag  1740
gtgccattc  acaacacat  tgatagcca  atggagaaa  ctgtgcgga  gcatcccgg  1800
ctgtttcca  gtctgctag  catttaggg  agggaaggg  acttttaat  taatgactt  1860
ttgcaccat  ttgcctggt  gactggact  gactgtgtc  gcattgatg  actccactt  1920
ttatgcctt  cattgtgat  acgtcaaac  cagtgaacg  cttcagtca  gctatggaa  1980
ttgtgtatc  tcattactg  atcatttgt  ggagtgcaa  ggtaatcat  tattgaact  2040
caagagcaa  atatttgtg  ggaatgatc  tgggtgggg  caagagaaa  ttaagaaag  2100
ttttaattc  cgatgtgtt  tcctgggta  ctagggaag  tg  2142



<210> 3958
<211> 447
<212> PRT
<213> Rattus norvegicus
<308> P36876
<400> 3958

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
  1               5                  10                  15
Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
             20                  25                  30
Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
         35                  40                  45
Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
     50                  55                  60
Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
 65                  70                  75                  80
Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                 85                  90                  95
Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
             100                105                110
Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
         115                120                125
Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
     130                135                140
Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
 145                150                155                160
Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                 165                170                175
Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
             180                185                190
Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
         195                200                205
Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
     210                215                220
Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
 225                230                235                240
Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                 245                250                255
Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
             260                265                270
Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
         275                280                285
Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
     290                295                300
Tyr Leu Ser Val Lys Val Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
 305                310                315                320
Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                 325                330                335
Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
             340                345                350
Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
         355                360                365
Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
     370                375                380
Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
 385                390                395                400
Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                 405                410                415
Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
             420                425                430
Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440                445



<210> 3959
<211> 796
<212> DNA
<213> Homo sapiens
<308> BM014893
<400> 3959

gttgtcatg  ctggatctt  caataattt  ttcagaatg  tgacagaaa  acaaagcga  60
acataaccc  agaagcatc  cgggaaaac  ataagcctc  cacagttct  aagcctcgc  120
aagtctgtg  aagtggcaa  cgaaagaaa  atgaaataa  tgttgacag  ctagacttc  180
ataagaaaa  ccttcacac  gcctggcac  cgttgtgac  tacacagag  aaaattgtg  240
taaaggctt  tctactctg  gatctcaat  cgaaatgaa  actcaggca  tttagtcca  300
agtggtact  tttgatgat  ttttccatt  ataaaatgt  atttcagat  attcgttta  360
aagctttat  attttatga  tttttaatc  tgtttgtca  agacttccc  agtgttgta  420
tacacgtag  cagaagcga  tgtcctttt  tttgcttca  gctaagagc  gcctcgctc  480
tgtcccccc  ttaggattc  attacatat  caatgtagg  tcaacctgt  cctttccct  540
ccagcaaac  ccacgcacc  aagagaaat  ttagcttat  tatgacggt  tatttacaa  600
aagagaaag  gaaaatctg  tattgcaat  atctgtgcc  tctttttac  accctctga  660
tggagcttt  tgatgcagc  accatgatt  aaaaaaatt  aaattacaa  aaaaatctg  720
cacttatcc  agtccacta  aggccactg  cttcaaagc  tctctcacc  tagcccaag  780
tcctaagag  agacgc  796



<210> 3960
<211> 447
<212> PRT
<213> Homo sapiens
<308> NP_002708
<400> 3960

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
  1               5                  10                  15
Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
             20                  25                  30
Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
         35                  40                  45
Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
     50                  55                  60
Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
 65                  70                  75                  80
Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                 85                  90                  95
Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
             100                105                110
Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
         115                120                125
Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
     130                135                140
Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
 145                150                155                160
Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                 165                170                175
Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
             180                185                190
Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
         195                200                205
Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
     210                215                220
Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
 225                230                235                240
Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                 245                250                255
Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
             260                265                270
Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
         275                280                285
Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
     290                295                300
Tyr Leu Ser Val Lys Ile Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
 305                310                315                320
Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                 325                330                335
Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
             340                345                350
Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
         355                360                365
Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
     370                375                380
Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
 385                390                395                400
Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                 405                410                415
Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
             420                425                430
Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440                445



<210> 3961
<211> 2142
<212> DNA
<213> Rattus norvegicus
<308> M83298
<400> 3961

ggggccgcc  tcgctgtcc  agccgccgc  gctgccgcc  ccgccgctg  cgtcttcac  60
gcgggagaa  gagcacgag  caggacgcc  ctgagtgaa  gccaccatc  tgccgacag  120
tccgcccgg  ctgcttcct  tccgcccag  tccccgtcc  ctcccccct  aggtgccat  180
cgcctccat  cgcgccctc  atcccccca  ccccaggtg  gggggctga  ccccggtcg  240
ggaggcccg  acgagcccg  cagggtcac  atttgcagc  cgacatggc  ggagctgga  300
gagggaatg  tattcaatg  tgtttttct  aggtgaaag  agcagttga  gatgacgta  360
cagaagcag  tataatttc  acagtagag  ttaatcatt  tggagaatt  ctagccaca  420
gagataaag  tgggagagt  gtcatcttt  aacaagagc  ggagaacaa  atccagtct  480
atagcagag  agaatacaa  gtttacagc  ccttccaga  ccatgagcc  gaatttgac  540
acttgaaaa  cttagaaat  gaagagaag  tcaacaaaa  taggtggtt  ccccagaaa  600
atgctgccc  gtttttatt  tctaccaat  ataaaacaa  aaaattatg  aaaatcagt  660
aaagagaca  aagaccaga  ggctataac  tgaaagagg  agatggaag  tatagagac  720
ctactacag  cactacact  cgagtgccg  tgtttaggc  catggatct  atggtggag  780
ccagtccgc  gagaatatt  gccaacgcc  atacctacc  catcaactc  atttctatc  840
atagtgatt  tgaaaccta  ttatcagca  atgatttgc  aattaatct  tggcatctg  900
aaattacag  caggagttt  aatattgtg  acattaagc  tgccaatat  gaggagctc  960
cggaggtga  cacagccgc  gagttccat  ccaacagct  taacacgtt  gtgtacagc  1020
gcagtaaag  gaccattcg  ttatgtgac  tgagggcat  tgcactctg  gacaggcat  1080
ctaaactgt  tgaagaacc  gaagatccc  gcaacaggt  gtttttttc  gaaatcatc  1140
cctcaattt  tgatgtaaa  ttcagccac  gtggtcgct  tatgatgac  agagactat  1200
tgtcagtca  agtttggga  ttgaatatg  aaaacaggc  cgtggagac  taccaggta  1260
acgaatacc  cagaagtaa  ctttgctca  tgtatgaaa  cgactgcat  tttgacaaa  1320
ttgaatgtt  ttggaatgg  tctgacagt  ttgtcatga  tggatccta  aataatttc  1380
tcagaatgt  cgacaggaa  acaaagcgg  atataactc  agaagcatc  cgagaaaac  1440
ataagcctc  tacagtttt  aaaccacgc  aagtctgtg  aagtggcaa  cgaaagaaa  1500
atgaaataa  tgttgacag  ctagacttc  acaagaaaa  ccttcatac  gcctggcat  1560
ccaaggaaa  catcattgc  gtagcgact  caaacaatc  gtatatatt  caagacaaa  1620
tgaattagg  tggcattct  tgcagagga  ccacttcct  cttagtgag  tagttgaat  1680
tagcattcg  acctataag  gagcggtcc  ttgtggcgt  cctttccag  gtttgacag  1740
gtgccattc  acaacacat  tgatagcca  atggagaaa  ctgtgcgga  gcatcccgg  1800
ctgtttcca  gtctgctag  catttaggg  agggaaggg  acttttaat  taatgactt  1860
ttgcaccat  ttgcctggt  gactggact  gactgtgtc  gcattgatg  actccactt  1920
ttatgcctt  cattgtgat  acgtcaaac  cagtgaacg  cttcagtca  gctatggaa  1980
ttgtgtatc  tcattactg  atcatttgt  ggagtgcaa  ggtaatcat  tattgaact  2040
caagagcaa  atatttgtg  ggaatgatc  tgggtgggg  caagagaaa  ttaagaaag  2100
ttttaattc  cgatgtgtt  tcctgggta  ctagggaag  tg  2142



<210> 3962
<211> 447
<212> PRT
<213> Rattus norvegicus
<308> P36876
<400> 3962

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
  1               5                  10                  15
Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
             20                  25                  30
Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
         35                  40                  45
Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
     50                  55                  60
Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
 65                  70                  75                  80
Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                 85                  90                  95
Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
             100                105                110
Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
         115                120                125
Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
     130                135                140
Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
 145                150                155                160
Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                 165                170                175
Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
             180                185                190
Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
         195                200                205
Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
     210                215                220
Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
 225                230                235                240
Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                 245                250                255
Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
             260                265                270
Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
         275                280                285
Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
     290                295                300
Tyr Leu Ser Val Lys Val Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
 305                310                315                320
Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                 325                330                335
Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
             340                345                350
Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
         355                360                365
Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
     370                375                380
Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
 385                390                395                400
Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                 405                410                415
Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
             420                425                430
Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440                445



<210> 3963
<211> 796
<212> DNA
<213> Homo sapiens
<308> BM014893
<400> 3963

gttgtcatg  ctggatctt  caataattt  ttcagaatg  tgacagaaa  acaaagcga  60
acataaccc  agaagcatc  cgggaaaac  ataagcctc  cacagttct  aagcctcgc  120
aagtctgtg  aagtggcaa  cgaaagaaa  atgaaataa  tgttgacag  ctagacttc  180
ataagaaaa  ccttcacac  gcctggcac  cgttgtgac  tacacagag  aaaattgtg  240
taaaggctt  tctactctg  gatctcaat  cgaaatgaa  actcaggca  tttagtcca  300
agtggtact  tttgatgat  ttttccatt  ataaaatgt  atttcagat  attcgttta  360
aagctttat  attttatga  tttttaatc  tgtttgtca  agacttccc  agtgttgta  420
tacacgtag  cagaagcga  tgtcctttt  tttgcttca  gctaagagc  gcctcgctc  480
tgtcccccc  ttaggattc  attacatat  caatgtagg  tcaacctgt  cctttccct  540
ccagcaaac  ccacgcacc  aagagaaat  ttagcttat  tatgacggt  tatttacaa  600
aagagaaag  gaaaatctg  tattgcaat  atctgtgcc  tctttttac  accctctga  660
tggagcttt  tgatgcagc  accatgatt  aaaaaaatt  aaattacaa  aaaaatctg  720
cacttatcc  agtccacta  aggccactg  cttcaaagc  tctctcacc  tagcccaag  780
tcctaagag  agacgc  796



<210> 3964
<211> 447
<212> PRT
<213> Homo sapiens
<308> NP_002708
<400> 3964

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
  1               5                  10                  15
Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
             20                  25                  30
Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
         35                  40                  45
Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
     50                  55                  60
Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
 65                  70                  75                  80
Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                 85                  90                  95
Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
             100                105                110
Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
         115                120                125
Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
     130                135                140
Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
 145                150                155                160
Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                 165                170                175
Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
             180                185                190
Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
         195                200                205
Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
     210                215                220
Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
 225                230                235                240
Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                 245                250                255
Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
             260                265                270
Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
         275                280                285
Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
     290                295                300
Tyr Leu Ser Val Lys Ile Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
 305                310                315                320
Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                 325                330                335
Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
             340                345                350
Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
         355                360                365
Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
     370                375                380
Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
 385                390                395                400
Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                 405                410                415
Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
             420                425                430
Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440                445



<210> 3965
<211> 2142
<212> DNA
<213> Rattus norvegicus
<308> M83298
<400> 3965

ggggccgcc  tcgctgtcc  agccgccgc  gctgccgcc  ccgccgctg  cgtcttcac  60
gcgggagaa  gagcacgag  caggacgcc  ctgagtgaa  gccaccatc  tgccgacag  120
tccgcccgg  ctgcttcct  tccgcccag  tccccgtcc  ctcccccct  aggtgccat  180
cgcctccat  cgcgccctc  atcccccca  ccccaggtg  gggggctga  ccccggtcg  240
ggaggcccg  acgagcccg  cagggtcac  atttgcagc  cgacatggc  ggagctgga  300
gagggaatg  tattcaatg  tgtttttct  aggtgaaag  agcagttga  gatgacgta  360
cagaagcag  tataatttc  acagtagag  ttaatcatt  tggagaatt  ctagccaca  420
gagataaag  tgggagagt  gtcatcttt  aacaagagc  ggagaacaa  atccagtct  480
atagcagag  agaatacaa  gtttacagc  ccttccaga  ccatgagcc  gaatttgac  540
acttgaaaa  cttagaaat  gaagagaag  tcaacaaaa  taggtggtt  ccccagaaa  600
atgctgccc  gtttttatt  tctaccaat  ataaaacaa  aaaattatg  aaaatcagt  660
aaagagaca  aagaccaga  ggctataac  tgaaagagg  agatggaag  tatagagac  720
ctactacag  cactacact  cgagtgccg  tgtttaggc  catggatct  atggtggag  780
ccagtccgc  gagaatatt  gccaacgcc  atacctacc  catcaactc  atttctatc  840
atagtgatt  tgaaaccta  ttatcagca  atgatttgc  aattaatct  tggcatctg  900
aaattacag  caggagttt  aatattgtg  acattaagc  tgccaatat  gaggagctc  960
cggaggtga  cacagccgc  gagttccat  ccaacagct  taacacgtt  gtgtacagc  1020
gcagtaaag  gaccattcg  ttatgtgac  tgagggcat  tgcactctg  gacaggcat  1080
ctaaactgt  tgaagaacc  gaagatccc  gcaacaggt  gtttttttc  gaaatcatc  1140
cctcaattt  tgatgtaaa  ttcagccac  gtggtcgct  tatgatgac  agagactat  1200
tgtcagtca  agtttggga  ttgaatatg  aaaacaggc  cgtggagac  taccaggta  1260
acgaatacc  cagaagtaa  ctttgctca  tgtatgaaa  cgactgcat  tttgacaaa  1320
ttgaatgtt  ttggaatgg  tctgacagt  ttgtcatga  tggatccta  aataatttc  1380
tcagaatgt  cgacaggaa  acaaagcgg  atataactc  agaagcatc  cgagaaaac  1440
ataagcctc  tacagtttt  aaaccacgc  aagtctgtg  aagtggcaa  cgaaagaaa  1500
atgaaataa  tgttgacag  ctagacttc  acaagaaaa  ccttcatac  gcctggcat  1560
ccaaggaaa  catcattgc  gtagcgact  caaacaatc  gtatatatt  caagacaaa  1620
tgaattagg  tggcattct  tgcagagga  ccacttcct  cttagtgag  tagttgaat  1680
tagcattcg  acctataag  gagcggtcc  ttgtggcgt  cctttccag  gtttgacag  1740
gtgccattc  acaacacat  tgatagcca  atggagaaa  ctgtgcgga  gcatcccgg  1800
ctgtttcca  gtctgctag  catttaggg  agggaaggg  acttttaat  taatgactt  1860
ttgcaccat  ttgcctggt  gactggact  gactgtgtc  gcattgatg  actccactt  1920
ttatgcctt  cattgtgat  acgtcaaac  cagtgaacg  cttcagtca  gctatggaa  1980
ttgtgtatc  tcattactg  atcatttgt  ggagtgcaa  ggtaatcat  tattgaact  2040
caagagcaa  atatttgtg  ggaatgatc  tgggtgggg  caagagaaa  ttaagaaag  2100
ttttaattc  cgatgtgtt  tcctgggta  ctagggaag  tg  2142



<210> 3966
<211> 447
<212> PRT
<213> Rattus norvegicus
<308> P36876
<400> 3966

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
  1               5                  10                  15
Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
             20                  25                  30
Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
         35                  40                  45
Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
     50                  55                  60
Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
 65                  70                  75                  80
Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                 85                  90                  95
Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
             100                105                110
Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
         115                120                125
Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
     130                135                140
Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
 145                150                155                160
Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                 165                170                175
Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
             180                185                190
Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
         195                200                205
Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
     210                215                220
Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
 225                230                235                240
Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                 245                250                255
Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
             260                265                270
Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
         275                280                285
Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
     290                295                300
Tyr Leu Ser Val Lys Val Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
 305                310                315                320
Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                 325                330                335
Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
             340                345                350
Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
         355                360                365
Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
     370                375                380
Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
 385                390                395                400
Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                 405                410                415
Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
             420                425                430
Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440                445



<210> 3967
<211> 796
<212> DNA
<213> Homo sapiens
<308> BM014893
<400> 3967

gttgtcatg  ctggatctt  caataattt  ttcagaatg  tgacagaaa  acaaagcga  60
acataaccc  agaagcatc  cgggaaaac  ataagcctc  cacagttct  aagcctcgc  120
aagtctgtg  aagtggcaa  cgaaagaaa  atgaaataa  tgttgacag  ctagacttc  180
ataagaaaa  ccttcacac  gcctggcac  cgttgtgac  tacacagag  aaaattgtg  240
taaaggctt  tctactctg  gatctcaat  cgaaatgaa  actcaggca  tttagtcca  300
agtggtact  tttgatgat  ttttccatt  ataaaatgt  atttcagat  attcgttta  360
aagctttat  attttatga  tttttaatc  tgtttgtca  agacttccc  agtgttgta  420
tacacgtag  cagaagcga  tgtcctttt  tttgcttca  gctaagagc  gcctcgctc  480
tgtcccccc  ttaggattc  attacatat  caatgtagg  tcaacctgt  cctttccct  540
ccagcaaac  ccacgcacc  aagagaaat  ttagcttat  tatgacggt  tatttacaa  600
aagagaaag  gaaaatctg  tattgcaat  atctgtgcc  tctttttac  accctctga  660
tggagcttt  tgatgcagc  accatgatt  aaaaaaatt  aaattacaa  aaaaatctg  720
cacttatcc  agtccacta  aggccactg  cttcaaagc  tctctcacc  tagcccaag  780
tcctaagag  agacgc  796



<210> 3968
<211> 447
<212> PRT
<213> Homo sapiens
<308> NP_002708
<400> 3968

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
  1               5                  10                  15
Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
             20                  25                  30
Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
         35                  40                  45
Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
     50                  55                  60
Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
 65                  70                  75                  80
Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                 85                  90                  95
Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
             100                105                110
Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
         115                120                125
Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
     130                135                140
Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
 145                150                155                160
Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                 165                170                175
Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
             180                185                190
Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
         195                200                205
Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
     210                215                220
Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
 225                230                235                240
Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                 245                250                255
Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
             260                265                270
Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
         275                280                285
Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
     290                295                300
Tyr Leu Ser Val Lys Ile Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
 305                310                315                320
Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                 325                330                335
Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
             340                345                350
Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
         355                360                365
Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
     370                375                380
Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
 385                390                395                400
Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                 405                410                415
Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
             420                425                430
Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440                445



<210> 3969
<211> 2142
<212> DNA
<213> Rattus norvegicus
<308> M83298
<400> 3969

ggggccgcc  tcgctgtcc  agccgccgc  gctgccgcc  ccgccgctg  cgtcttcac  60
gcgggagaa  gagcacgag  caggacgcc  ctgagtgaa  gccaccatc  tgccgacag  120
tccgcccgg  ctgcttcct  tccgcccag  tccccgtcc  ctcccccct  aggtgccat  180
cgcctccat  cgcgccctc  atcccccca  ccccaggtg  gggggctga  ccccggtcg  240
ggaggcccg  acgagcccg  cagggtcac  atttgcagc  cgacatggc  ggagctgga  300
gagggaatg  tattcaatg  tgtttttct  aggtgaaag  agcagttga  gatgacgta  360
cagaagcag  tataatttc  acagtagag  ttaatcatt  tggagaatt  ctagccaca  420
gagataaag  tgggagagt  gtcatcttt  aacaagagc  ggagaacaa  atccagtct  480
atagcagag  agaatacaa  gtttacagc  ccttccaga  ccatgagcc  gaatttgac  540
acttgaaaa  cttagaaat  gaagagaag  tcaacaaaa  taggtggtt  ccccagaaa  600
atgctgccc  gtttttatt  tctaccaat  ataaaacaa  aaaattatg  aaaatcagt  660
aaagagaca  aagaccaga  ggctataac  tgaaagagg  agatggaag  tatagagac  720
ctactacag  cactacact  cgagtgccg  tgtttaggc  catggatct  atggtggag  780
ccagtccgc  gagaatatt  gccaacgcc  atacctacc  catcaactc  atttctatc  840
atagtgatt  tgaaaccta  ttatcagca  atgatttgc  aattaatct  tggcatctg  900
aaattacag  caggagttt  aatattgtg  acattaagc  tgccaatat  gaggagctc  960
cggaggtga  cacagccgc  gagttccat  ccaacagct  taacacgtt  gtgtacagc  1020
gcagtaaag  gaccattcg  ttatgtgac  tgagggcat  tgcactctg  gacaggcat  1080
ctaaactgt  tgaagaacc  gaagatccc  gcaacaggt  gtttttttc  gaaatcatc  1140
cctcaattt  tgatgtaaa  ttcagccac  gtggtcgct  tatgatgac  agagactat  1200
tgtcagtca  agtttggga  ttgaatatg  aaaacaggc  cgtggagac  taccaggta  1260
acgaatacc  cagaagtaa  ctttgctca  tgtatgaaa  cgactgcat  tttgacaaa  1320
ttgaatgtt  ttggaatgg  tctgacagt  ttgtcatga  tggatccta  aataatttc  1380
tcagaatgt  cgacaggaa  acaaagcgg  atataactc  agaagcatc  cgagaaaac  1440
ataagcctc  tacagtttt  aaaccacgc  aagtctgtg  aagtggcaa  cgaaagaaa  1500
atgaaataa  tgttgacag  ctagacttc  acaagaaaa  ccttcatac  gcctggcat  1560
ccaaggaaa  catcattgc  gtagcgact  caaacaatc  gtatatatt  caagacaaa  1620
tgaattagg  tggcattct  tgcagagga  ccacttcct  cttagtgag  tagttgaat  1680
tagcattcg  acctataag  gagcggtcc  ttgtggcgt  cctttccag  gtttgacag  1740
gtgccattc  acaacacat  tgatagcca  atggagaaa  ctgtgcgga  gcatcccgg  1800
ctgtttcca  gtctgctag  catttaggg  agggaaggg  acttttaat  taatgactt  1860
ttgcaccat  ttgcctggt  gactggact  gactgtgtc  gcattgatg  actccactt  1920
ttatgcctt  cattgtgat  acgtcaaac  cagtgaacg  cttcagtca  gctatggaa  1980
ttgtgtatc  tcattactg  atcatttgt  ggagtgcaa  ggtaatcat  tattgaact  2040
caagagcaa  atatttgtg  ggaatgatc  tgggtgggg  caagagaaa  ttaagaaag  2100
ttttaattc  cgatgtgtt  tcctgggta  ctagggaag  tg  2142



<210> 3970
<211> 447
<212> PRT
<213> Rattus norvegicus
<308> P36876
<400> 3970

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
  1               5                  10                  15
Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
             20                  25                  30
Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
         35                  40                  45
Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
     50                  55                  60
Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
 65                  70                  75                  80
Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                 85                  90                  95
Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
             100                105                110
Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
         115                120                125
Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
     130                135                140
Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
 145                150                155                160
Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                 165                170                175
Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
             180                185                190
Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
         195                200                205
Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
     210                215                220
Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
 225                230                235                240
Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                 245                250                255
Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
             260                265                270
Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
         275                280                285
Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
     290                295                300
Tyr Leu Ser Val Lys Val Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
 305                310                315                320
Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                 325                330                335
Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
             340                345                350
Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
         355                360                365
Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
     370                375                380
Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
 385                390                395                400
Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                 405                410                415
Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
             420                425                430
Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440                445



<210> 3971
<211> 796
<212> DNA
<213> Homo sapiens
<308> BM014893
<400> 3971

gttgtcatg  ctggatctt  caataattt  ttcagaatg  tgacagaaa  acaaagcga  60
acataaccc  agaagcatc  cgggaaaac  ataagcctc  cacagttct  aagcctcgc  120
aagtctgtg  aagtggcaa  cgaaagaaa  atgaaataa  tgttgacag  ctagacttc  180
ataagaaaa  ccttcacac  gcctggcac  cgttgtgac  tacacagag  aaaattgtg  240
taaaggctt  tctactctg  gatctcaat  cgaaatgaa  actcaggca  tttagtcca  300
agtggtact  tttgatgat  ttttccatt  ataaaatgt  atttcagat  attcgttta  360
aagctttat  attttatga  tttttaatc  tgtttgtca  agacttccc  agtgttgta  420
tacacgtag  cagaagcga  tgtcctttt  tttgcttca  gctaagagc  gcctcgctc  480
tgtcccccc  ttaggattc  attacatat  caatgtagg  tcaacctgt  cctttccct  540
ccagcaaac  ccacgcacc  aagagaaat  ttagcttat  tatgacggt  tatttacaa  600
aagagaaag  gaaaatctg  tattgcaat  atctgtgcc  tctttttac  accctctga  660
tggagcttt  tgatgcagc  accatgatt  aaaaaaatt  aaattacaa  aaaaatctg  720
cacttatcc  agtccacta  aggccactg  cttcaaagc  tctctcacc  tagcccaag  780
tcctaagag  agacgc  796



<210> 3972
<211> 447
<212> PRT
<213> Homo sapiens
<308> NP_002708
<400> 3972

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
  1               5                  10                  15
Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
             20                  25                  30
Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
         35                  40                  45
Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
     50                  55                  60
Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
 65                  70                  75                  80
Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                 85                  90                  95
Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
             100                105                110
Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
         115                120                125
Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
     130                135                140
Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
 145                150                155                160
Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                 165                170                175
Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
             180                185                190
Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
         195                200                205
Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
     210                215                220
Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
 225                230                235                240
Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                 245                250                255
Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
             260                265                270
Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
         275                280                285
Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
     290                295                300
Tyr Leu Ser Val Lys Ile Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
 305                310                315                320
Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                 325                330                335
Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
             340                345                350
Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
         355                360                365
Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
     370                375                380
Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
 385                390                395                400
Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                 405                410                415
Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
             420                425                430
Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440                445



<210> 3973
<211> 2142
<212> DNA
<213> Rattus norvegicus
<308> M83298
<400> 3973

ggggccgcc  tcgctgtcc  agccgccgc  gctgccgcc  ccgccgctg  cgtcttcac  60
gcgggagaa  gagcacgag  caggacgcc  ctgagtgaa  gccaccatc  tgccgacag  120
tccgcccgg  ctgcttcct  tccgcccag  tccccgtcc  ctcccccct  aggtgccat  180
cgcctccat  cgcgccctc  atcccccca  ccccaggtg  gggggctga  ccccggtcg  240
ggaggcccg  acgagcccg  cagggtcac  atttgcagc  cgacatggc  ggagctgga  300
gagggaatg  tattcaatg  tgtttttct  aggtgaaag  agcagttga  gatgacgta  360
cagaagcag  tataatttc  acagtagag  ttaatcatt  tggagaatt  ctagccaca  420
gagataaag  tgggagagt  gtcatcttt  aacaagagc  ggagaacaa  atccagtct  480
atagcagag  agaatacaa  gtttacagc  ccttccaga  ccatgagcc  gaatttgac  540
acttgaaaa  cttagaaat  gaagagaag  tcaacaaaa  taggtggtt  ccccagaaa  600
atgctgccc  gtttttatt  tctaccaat  ataaaacaa  aaaattatg  aaaatcagt  660
aaagagaca  aagaccaga  ggctataac  tgaaagagg  agatggaag  tatagagac  720
ctactacag  cactacact  cgagtgccg  tgtttaggc  catggatct  atggtggag  780
ccagtccgc  gagaatatt  gccaacgcc  atacctacc  catcaactc  atttctatc  840
atagtgatt  tgaaaccta  ttatcagca  atgatttgc  aattaatct  tggcatctg  900
aaattacag  caggagttt  aatattgtg  acattaagc  tgccaatat  gaggagctc  960
cggaggtga  cacagccgc  gagttccat  ccaacagct  taacacgtt  gtgtacagc  1020
gcagtaaag  gaccattcg  ttatgtgac  tgagggcat  tgcactctg  gacaggcat  1080
ctaaactgt  tgaagaacc  gaagatccc  gcaacaggt  gtttttttc  gaaatcatc  1140
cctcaattt  tgatgtaaa  ttcagccac  gtggtcgct  tatgatgac  agagactat  1200
tgtcagtca  agtttggga  ttgaatatg  aaaacaggc  cgtggagac  taccaggta  1260
acgaatacc  cagaagtaa  ctttgctca  tgtatgaaa  cgactgcat  tttgacaaa  1320
ttgaatgtt  ttggaatgg  tctgacagt  ttgtcatga  tggatccta  aataatttc  1380
tcagaatgt  cgacaggaa  acaaagcgg  atataactc  agaagcatc  cgagaaaac  1440
ataagcctc  tacagtttt  aaaccacgc  aagtctgtg  aagtggcaa  cgaaagaaa  1500
atgaaataa  tgttgacag  ctagacttc  acaagaaaa  ccttcatac  gcctggcat  1560
ccaaggaaa  catcattgc  gtagcgact  caaacaatc  gtatatatt  caagacaaa  1620
tgaattagg  tggcattct  tgcagagga  ccacttcct  cttagtgag  tagttgaat  1680
tagcattcg  acctataag  gagcggtcc  ttgtggcgt  cctttccag  gtttgacag  1740
gtgccattc  acaacacat  tgatagcca  atggagaaa  ctgtgcgga  gcatcccgg  1800
ctgtttcca  gtctgctag  catttaggg  agggaaggg  acttttaat  taatgactt  1860
ttgcaccat  ttgcctggt  gactggact  gactgtgtc  gcattgatg  actccactt  1920
ttatgcctt  cattgtgat  acgtcaaac  cagtgaacg  cttcagtca  gctatggaa  1980
ttgtgtatc  tcattactg  atcatttgt  ggagtgcaa  ggtaatcat  tattgaact  2040
caagagcaa  atatttgtg  ggaatgatc  tgggtgggg  caagagaaa  ttaagaaag  2100
ttttaattc  cgatgtgtt  tcctgggta  ctagggaag  tg  2142



<210> 3974
<211> 447
<212> PRT
<213> Rattus norvegicus
<308> P36876
<400> 3974

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
  1               5                  10                  15
Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
             20                  25                  30
Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
         35                  40                  45
Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
     50                  55                  60
Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
 65                  70                  75                  80
Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                 85                  90                  95
Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
             100                105                110
Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
         115                120                125
Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
     130                135                140
Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
 145                150                155                160
Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                 165                170                175
Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
             180                185                190
Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
         195                200                205
Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
     210                215                220
Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
 225                230                235                240
Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                 245                250                255
Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
             260                265                270
Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
         275                280                285
Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
     290                295                300
Tyr Leu Ser Val Lys Val Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
 305                310                315                320
Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                 325                330                335
Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
             340                345                350
Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
         355                360                365
Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
     370                375                380
Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
 385                390                395                400
Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                 405                410                415
Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
             420                425                430
Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440                445



<210> 3975
<211> 796
<212> DNA
<213> Homo sapiens
<308> BM014893
<400> 3975

gttgtcatg  ctggatctt  caataattt  ttcagaatg  tgacagaaa  acaaagcga  60
acataaccc  agaagcatc  cgggaaaac  ataagcctc  cacagttct  aagcctcgc  120
aagtctgtg  aagtggcaa  cgaaagaaa  atgaaataa  tgttgacag  ctagacttc  180
ataagaaaa  ccttcacac  gcctggcac  cgttgtgac  tacacagag  aaaattgtg  240
taaaggctt  tctactctg  gatctcaat  cgaaatgaa  actcaggca  tttagtcca  300
agtggtact  tttgatgat  ttttccatt  ataaaatgt  atttcagat  attcgttta  360
aagctttat  attttatga  tttttaatc  tgtttgtca  agacttccc  agtgttgta  420
tacacgtag  cagaagcga  tgtcctttt  tttgcttca  gctaagagc  gcctcgctc  480
tgtcccccc  ttaggattc  attacatat  caatgtagg  tcaacctgt  cctttccct  540
ccagcaaac  ccacgcacc  aagagaaat  ttagcttat  tatgacggt  tatttacaa  600
aagagaaag  gaaaatctg  tattgcaat  atctgtgcc  tctttttac  accctctga  660
tggagcttt  tgatgcagc  accatgatt  aaaaaaatt  aaattacaa  aaaaatctg  720
cacttatcc  agtccacta  aggccactg  cttcaaagc  tctctcacc  tagcccaag  780
tcctaagag  agacgc  796



<210> 3976
<211> 447
<212> PRT
<213> Homo sapiens
<308> NP_002708
<400> 3976

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
  1               5                  10                  15
Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
             20                  25                  30
Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
         35                  40                  45
Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
     50                  55                  60
Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
 65                  70                  75                  80
Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                 85                  90                  95
Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
             100                105                110
Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
         115                120                125
Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
     130                135                140
Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
 145                150                155                160
Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                 165                170                175
Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
             180                185                190
Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
         195                200                205
Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
     210                215                220
Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
 225                230                235                240
Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                 245                250                255
Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
             260                265                270
Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
         275                280                285
Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
     290                295                300
Tyr Leu Ser Val Lys Ile Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
 305                310                315                320
Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                 325                330                335
Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
             340                345                350
Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
         355                360                365
Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
     370                375                380
Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
 385                390                395                400
Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                 405                410                415
Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
             420                425                430
Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440                445



<210> 3977
<211> 2142
<212> DNA
<213> Rattus norvegicus
<308> M83298
<400> 3977

ggggccgcc  tcgctgtcc  agccgccgc  gctgccgcc  ccgccgctg  cgtcttcac  60
gcgggagaa  gagcacgag  caggacgcc  ctgagtgaa  gccaccatc  tgccgacag  120
tccgcccgg  ctgcttcct  tccgcccag  tccccgtcc  ctcccccct  aggtgccat  180
cgcctccat  cgcgccctc  atcccccca  ccccaggtg  gggggctga  ccccggtcg  240
ggaggcccg  acgagcccg  cagggtcac  atttgcagc  cgacatggc  ggagctgga  300
gagggaatg  tattcaatg  tgtttttct  aggtgaaag  agcagttga  gatgacgta  360
cagaagcag  tataatttc  acagtagag  ttaatcatt  tggagaatt  ctagccaca  420
gagataaag  tgggagagt  gtcatcttt  aacaagagc  ggagaacaa  atccagtct  480
atagcagag  agaatacaa  gtttacagc  ccttccaga  ccatgagcc  gaatttgac  540
acttgaaaa  cttagaaat  gaagagaag  tcaacaaaa  taggtggtt  ccccagaaa  600
atgctgccc  gtttttatt  tctaccaat  ataaaacaa  aaaattatg  aaaatcagt  660
aaagagaca  aagaccaga  ggctataac  tgaaagagg  agatggaag  tatagagac  720
ctactacag  cactacact  cgagtgccg  tgtttaggc  catggatct  atggtggag  780
ccagtccgc  gagaatatt  gccaacgcc  atacctacc  catcaactc  atttctatc  840
atagtgatt  tgaaaccta  ttatcagca  atgatttgc  aattaatct  tggcatctg  900
aaattacag  caggagttt  aatattgtg  acattaagc  tgccaatat  gaggagctc  960
cggaggtga  cacagccgc  gagttccat  ccaacagct  taacacgtt  gtgtacagc  1020
gcagtaaag  gaccattcg  ttatgtgac  tgagggcat  tgcactctg  gacaggcat  1080
ctaaactgt  tgaagaacc  gaagatccc  gcaacaggt  gtttttttc  gaaatcatc  1140
cctcaattt  tgatgtaaa  ttcagccac  gtggtcgct  tatgatgac  agagactat  1200
tgtcagtca  agtttggga  ttgaatatg  aaaacaggc  cgtggagac  taccaggta  1260
acgaatacc  cagaagtaa  ctttgctca  tgtatgaaa  cgactgcat  tttgacaaa  1320
ttgaatgtt  ttggaatgg  tctgacagt  ttgtcatga  tggatccta  aataatttc  1380
tcagaatgt  cgacaggaa  acaaagcgg  atataactc  agaagcatc  cgagaaaac  1440
ataagcctc  tacagtttt  aaaccacgc  aagtctgtg  aagtggcaa  cgaaagaaa  1500
atgaaataa  tgttgacag  ctagacttc  acaagaaaa  ccttcatac  gcctggcat  1560
ccaaggaaa  catcattgc  gtagcgact  caaacaatc  gtatatatt  caagacaaa  1620
tgaattagg  tggcattct  tgcagagga  ccacttcct  cttagtgag  tagttgaat  1680
tagcattcg  acctataag  gagcggtcc  ttgtggcgt  cctttccag  gtttgacag  1740
gtgccattc  acaacacat  tgatagcca  atggagaaa  ctgtgcgga  gcatcccgg  1800
ctgtttcca  gtctgctag  catttaggg  agggaaggg  acttttaat  taatgactt  1860
ttgcaccat  ttgcctggt  gactggact  gactgtgtc  gcattgatg  actccactt  1920
ttatgcctt  cattgtgat  acgtcaaac  cagtgaacg  cttcagtca  gctatggaa  1980
ttgtgtatc  tcattactg  atcatttgt  ggagtgcaa  ggtaatcat  tattgaact  2040
caagagcaa  atatttgtg  ggaatgatc  tgggtgggg  caagagaaa  ttaagaaag  2100
ttttaattc  cgatgtgtt  tcctgggta  ctagggaag  tg  2142



<210> 3978
<211> 447
<212> PRT
<213> Rattus norvegicus
<308> P36876
<400> 3978

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
  1               5                  10                  15
Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
             20                  25                  30
Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
         35                  40                  45
Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
     50                  55                  60
Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
 65                  70                  75                  80
Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                 85                  90                  95
Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
             100                105                110
Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
         115                120                125
Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
     130                135                140
Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
 145                150                155                160
Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                 165                170                175
Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
             180                185                190
Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
         195                200                205
Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
     210                215                220
Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
 225                230                235                240
Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                 245                250                255
Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
             260                265                270
Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
         275                280                285
Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
     290                295                300
Tyr Leu Ser Val Lys Val Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
 305                310                315                320
Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                 325                330                335
Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
             340                345                350
Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
         355                360                365
Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
     370                375                380
Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
 385                390                395                400
Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                 405                410                415
Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
             420                425                430
Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440                445



<210> 3979
<211> 796
<212> DNA
<213> Homo sapiens
<308> BM014893
<400> 3979

gttgtcatg  ctggatctt  caataattt  ttcagaatg  tgacagaaa  acaaagcga  60
acataaccc  agaagcatc  cgggaaaac  ataagcctc  cacagttct  aagcctcgc  120
aagtctgtg  aagtggcaa  cgaaagaaa  atgaaataa  tgttgacag  ctagacttc  180
ataagaaaa  ccttcacac  gcctggcac  cgttgtgac  tacacagag  aaaattgtg  240
taaaggctt  tctactctg  gatctcaat  cgaaatgaa  actcaggca  tttagtcca  300
agtggtact  tttgatgat  ttttccatt  ataaaatgt  atttcagat  attcgttta  360
aagctttat  attttatga  tttttaatc  tgtttgtca  agacttccc  agtgttgta  420
tacacgtag  cagaagcga  tgtcctttt  tttgcttca  gctaagagc  gcctcgctc  480
tgtcccccc  ttaggattc  attacatat  caatgtagg  tcaacctgt  cctttccct  540
ccagcaaac  ccacgcacc  aagagaaat  ttagcttat  tatgacggt  tatttacaa  600
aagagaaag  gaaaatctg  tattgcaat  atctgtgcc  tctttttac  accctctga  660
tggagcttt  tgatgcagc  accatgatt  aaaaaaatt  aaattacaa  aaaaatctg  720
cacttatcc  agtccacta  aggccactg  cttcaaagc  tctctcacc  tagcccaag  780
tcctaagag  agacgc  796



<210> 3980
<211> 447
<212> PRT
<213> Homo sapiens
<308> NP_002708
<400> 3980

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
  1               5                  10                  15
Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
             20                  25                  30
Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
         35                  40                  45
Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
     50                  55                  60
Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
 65                  70                  75                  80
Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                 85                  90                  95
Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
             100                105                110
Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
         115                120                125
Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
     130                135                140
Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
 145                150                155                160
Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                 165                170                175
Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
             180                185                190
Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
         195                200                205
Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
     210                215                220
Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
 225                230                235                240
Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                 245                250                255
Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
             260                265                270
Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
         275                280                285
Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
     290                295                300
Tyr Leu Ser Val Lys Ile Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
 305                310                315                320
Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                 325                330                335
Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
             340                345                350
Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
         355                360                365
Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
     370                375                380
Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
 385                390                395                400
Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                 405                410                415
Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
             420                425                430
Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
         435                440                445



<210> 3981
<211> 3185
<212> DNA
<213> Rattus norvegicus
<308> M83561
<400> 3981

ggctaggaa  cccgcttca  gtccccacg  ttgttccct  cacctcgct  tcctgagag  60
agagagcgc  cggtgtgca  actcggagc  ttccgggag  atgaggcgg  gacccagcc  120
aagttgggt  catcttgcg  gcgtgaggc  acaactggg  ttcggcatg  attaagaag  180
ttgaaagat  gagcgcagc  cagtcctta  ccaacccgg  ctctggacc  gggacacca  240
ctggacact  ctctatttc  tgtgctaca  cctccctca  acctcccct  aagtgctca  300
gatcggagg  atttttgaa  ctgtggaaa  tgaacctgt  aatgttgaa  aattagctt  360
caagtttgc  gtcaccagt  ttaaccgaa  ccgaacctt  atgcccaat  ccacattaa  420
ctatgacat  cagagaatt  atctttttg  tagttttga  gcctcccga  gagcatgcg  480
ccagctggc  ctcggggtg  ccgcactct  cggcccttc  cacagctcc  ccgtcagtg  540
tgtacagtc  atttgcaat  ctctggaag  tccacacat  cagactcgc  ggaaacacc  600
ttccgtgga  agcagagac  tattttata  caacctcta  ccggactat  cggctatca  660
cagggcggt  ctggatttg  tcctctatt  caactggaa  acagtgacg  tggtgtatg  720
agatagcac  ggtctaatt  gtctgcaag  gctcatcaa  gctccctcc  gatacaaca  780
taaaatcaa  atccgccag  ttccccctg  gaataaaga  gccaaacct  tgctcaagg  840
gatgaagaa  agcaaagag  tctatgtga  atttgattg  tcgcacgaa  cagctgcgg  900
aattcttaa  cagattttg  tcatgggca  gatgactga  tattatcac  acttcttca  960
aaccctgga  ttgtttgct  tagatctgg  actctatag  tacagcggt  taaatatga  1020
tggatttcg  ttgctgaat  ttgacaacc  tcacgtgtc  tccatcatt  agaagtggt  1080
catggagag  ttgcaggcc  cgcccagac  cgagactgg  cttctggat  gcatgatga  1140
aactgaagc  gcgctgatg  acgatgctg  gtacatggt  gccattgcg  cccaccgtg  1200
ctctcagct  accgtcagc  ccctgcagt  ccatcgaca  aagccatgg  gccttggac  1260
cagatttat  aacctcatc  aagaggctc  gtgggacgg  ttgactggg  ggatcacct  1320
caataagac  gatggcttg  gaaaggatt  tgacctgga  attatcagt  tcaaagagg  1380
aggaactga  aagattggg  tttggaact  caacagtgg  ctgaacatg  cggatggca  1440
cagagacag  tccaacaat  tcacggact  gctggctaa  cgcacactc  ttgtcacca  1500
tattctgga  gagccctac  tgatgtaca  gaaatccga  aagcccttg  atggaaacg  1560
caggtttga  ggatattgc  tggatctgc  gaaagaact  tccaatatc  tgggttttc  1620
ttacgatgt  aaactggtt  ctgatggca  atatggagc  cagaatgac  aaggggaat  1680
gaatgggat  gtaaaagaa  tcatcgacc  cagagctga  ctggcagtg  cccctctca  1740
catcacata  gtacgggag  aagtcattg  cttctccaa  cccttcatg  ccctgggca  1800
tagcatcct  taccggaag  ccaatggaa  caacccggg  gtcttctcc  tcctcaacc  1860
cctatctcc  gacatttgg  tgtacgtgc  gctcgcctg  ctaggagtc  gttgtgtac  1920
gtttgtgat  gcgaggttc  caccctacg  gtggtataa  ccccaccca  gcaaccccg  1980
ctcagacgt  gtggaaaac  atttcactt  gctaaatag  ttctggttt  gagttggag  2040
tctcatgca  caaggatca  agctgatgc  caaggctct  tcgaccaga  tagttggag  2100
aatatggtg  tttttcacc  taatcatca  ttcatccta  acggccaac  tggctgcct  2160
cttgacggt  gaaagaatg  aatccccca  cgattccgc  gacgatctg  ccaaacaaa  2220
caagataga  tatggggca  tcagagatg  ctcgacgat  accttcttc  agaaatcaa  2280
gatctccac  tatgagaaa  tgtgggctt  catgagcag  agacagcag  gcgcactgg  2340
taaaaacag  gacgagggg  tccaaaggg  gctcaccac  gactacgca  tgctgatgg  2400
gtccaccag  attgagtat  tgacgcaga  gaactgcaa  ctcactcag  tcgggggcc  2460
catagactc  aaaggctat  gagtgggga  gcctatcgg  tccccttac  gggataaaa  2520
tacgattgc  attcttcaa  tgcaagaag  agggaagct  catatgatg  aagagaagt  2580
gtggagggg  aatggctgc  ctgaagaag  cagtaagga  gccagtgct  tgggagtgg  2640
aaatatcgg  ggcatcttc  ttgttctgg  tgcaggact  gtgctttct  tgtttgtag  2700
cattggaga  tttttatac  aatcacgga  gaacaatga  gttgagcag  gtctctctt  2760
caatgccat  atggaagag  tgggaatat  cctcaagaa  cagaaaaaa  taaagaaaa  2820
gtcaagaac  aagggcaaa  cttctttca  aagtatcct  acttgtcac  agagacgaa  2880
tcagagaaa  gagacagtg  cgtgatcaa  gaacacacc  gtaagaaga  aaagcccac  2940
cgtccgctg  acatatttg  aggacagat  tcagaggac  atgtcttta  ccataaccc  3000
agtcgtgga  agaggggga  gaaatgcac  atttttaaa  ctcacatag  tattacttg  3060
gaagtgaaa  tgattcttt  cagatgaat  tgtatgcac  cttattttg  atttttcca  3120
ttcctccga  aaattgcta  gtgtgcttt  taaataata  taaacaagc  gactttgtt  3180
ttcat  3185



<210> 3982
<211> 949
<212> PRT
<213> Rattus norvegicus
<308> P22756
<400> 3982

Met Glu Arg Ser Thr Val Leu Ile Gln Pro Gly Leu Trp Thr Arg Asp 
  1               5                  10                  15
Thr Ser Trp Thr Leu Leu Tyr Phe Leu Cys Tyr Ile Leu Pro Gln Thr 
             20                  25                  30
Ser Pro Gln Val Leu Arg Ile Gly Gly Ile Phe Glu Thr Val Glu Asn 
         35                  40                  45
Glu Pro Val Asn Val Glu Glu Leu Ala Phe Lys Phe Ala Val Thr Ser 
     50                  55                  60
Ile Asn Arg Asn Arg Thr Leu Met Pro Asn Thr Thr Leu Thr Tyr Asp 
 65                  70                  75                  80
Ile Gln Arg Ile Asn Leu Phe Asp Ser Phe Glu Ala Ser Arg Arg Ala 
                 85                  90                  95
Cys Asp Gln Leu Ala Leu Gly Val Ala Ala Leu Phe Gly Pro Ser His 
             100                105                110
Ser Ser Ser Val Ser Ala Val Gln Ser Ile Cys Asn Ala Leu Glu Val 
         115                120                125
Pro His Ile Gln Thr Arg Trp Lys His Pro Ser Val Asp Ser Arg Asp 
     130                135                140
Leu Phe Tyr Ile Asn Leu Tyr Pro Asp Tyr Ala Ala Ile Ser Arg Ala 
 145                150                155                160
Val Leu Asp Leu Val Leu Tyr Tyr Asn Trp Lys Thr Val Thr Val Val 
                 165                170                175
Tyr Glu Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala 
             180                185                190
Pro Ser Arg Tyr Asn Ile Lys Ile Lys Ile Arg Gln Leu Pro Pro Ala 
         195                200                205
Asn Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Lys Ser Lys Glu 
     210                215                220
Phe Tyr Val Ile Phe Asp Cys Ser His Glu Thr Ala Ala Glu Ile Leu 
 225                230                235                240
Lys Gln Ile Leu Phe Met Gly Met Met Thr Glu Tyr Tyr His Tyr Phe 
                 245                250                255
Phe Thr Thr Leu Asp Leu Phe Ala Leu Asp Leu Glu Leu Tyr Arg Tyr 
             260                265                270
Ser Gly Val Asn Met Thr Gly Phe Arg Lys Leu Asn Ile Asp Asn Pro 
         275                280                285
His Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala 
     290                295                300
Pro Pro Arg Pro Glu Thr Gly Leu Leu Asp Gly Met Met Thr Thr Glu 
 305                310                315                320
Ala Ala Leu Met Tyr Asp Ala Val Tyr Met Val Ala Ile Ala Ser His 
                 325                330                335
Arg Ala Ser Gln Leu Thr Val Ser Ser Leu Gln Cys His Arg His Lys 
             340                345                350
Pro Cys Ala Leu Gly Pro Arg Phe Met Asn Leu Ile Lys Glu Ala Arg 
         355                360                365
Trp Asp Gly Leu Thr Gly Arg Ile Thr Phe Asn Lys Thr Asp Gly Leu 
     370                375                380
Arg Lys Asp Phe Asp Leu Asp Ile Ile Ser Leu Lys Glu Glu Gly Thr 
 385                390                395                400
Glu Lys Ala Ser Gly Glu Val Ser Lys His Leu Tyr Lys Val Trp Lys 
                 405                410                415
Lys Ile Gly Ile Trp Asn Ser Asn Ser Gly Leu Asn Met Thr Asp Gly 
             420                425                430
Asn Arg Asp Arg Ser Asn Asn Ile Thr Asp Ser Leu Ala Asn Arg Thr 
         435                440                445
Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Met Tyr Arg Lys 
     450                455                460
Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Ala Tyr Cys Leu 
 465                470                475                480
Asp Leu Leu Lys Glu Leu Ser Asn Ile Leu Gly Phe Leu Tyr Asp Val 
                 485                490                495
Lys Leu Val Pro Asp Gly Lys Tyr Gly Ala Gln Asn Asp Lys Gly Glu 
             500                505                510
Trp Asn Gly Met Val Lys Glu Leu Ile Asp His Arg Ala Asp Leu Ala 
         515                520                525
Val Ala Pro Leu Thr Ile Thr Tyr Val Arg Glu Lys Val Ile Asp Phe 
     530                535                540
Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys Pro 
 545                550                555                560
Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser Pro 
                 565                570                575
Asp Ile Trp Met Tyr Val Leu Leu Ala Cys Leu Gly Val Ser Cys Val 
             580                585                590
Leu Phe Val Ile Ala Arg Phe Thr Pro Tyr Glu Trp Tyr Asn Pro His 
         595                600                605
Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu Leu 
     610                615                620
Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser Glu 
 625                630                635                640
Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp Trp 
                 645                650                655
Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala 
             660                665                670
Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp Asp 
         675                680                685
Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Arg Asp Gly Ser 
     690                695                700
Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Glu Lys Met 
 705                710                715                720
Trp Ala Phe Met Ser Ser Arg Gln Gln Ser Ala Leu Val Lys Asn Ser 
                 725                730                735
Asp Glu Gly Ile Gln Arg Val Leu Thr Thr Asp Tyr Ala Leu Leu Met 
             740                745                750
Glu Ser Thr Ser Ile Glu Tyr Val Thr Gln Arg Asn Cys Asn Leu Thr 
         755                760                765
Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr Pro 
     770                775                780
Ile Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln Leu 
 785                790                795                800
Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg Gly 
                 805                810                815
Asn Gly Cys Pro Glu Glu Asp Ser Lys Glu Ala Ser Ala Leu Gly Val 
             820                825                830
Glu Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val Leu 
         835                840                845
Ser Val Phe Val Ala Ile Gly Glu Phe Leu Tyr Lys Ser Arg Lys Asn 
     850                855                860
Asn Asp Val Glu Gln Lys Gly Lys Ser Ser Arg Leu Arg Phe Tyr Phe 
 865                870                875                880
Arg Asn Lys Val Arg Phe His Gly Ser Lys Lys Glu Ser Leu Gly Val 
                 885                890                895
Glu Lys Cys Leu Ser Phe Asn Ala Ile Met Glu Glu Leu Gly Ile Ser 
             900                905                910
Leu Lys Asn Gln Lys Lys Leu Lys Lys Lys Ser Arg Thr Lys Gly Lys 
         915                920                925
Ser Ser Phe Thr Ser Ile Leu Thr Cys His Gln Arg Arg Thr Gln Arg 
     930                935                940
Lys Glu Thr Val Ala 
 945



<210> 3983
<211> 2718
<212> DNA
<213> Homo sapiens
<308> U16125
<400> 3983

atggagcac  gcacactcc  cgcccagcc  gggctctgg  ccagggaca  cagctgggc  60
ctcctctat  tcctctgct  tatcctccc  cagaccgcc  cgcaagtac  caggatcgg  120
gggattttt  aaacagtgg  aaatgagcc  gttaatgtt  aagaattag  tttcaagtt  180
gcagtcacc  gcattaaca  aaaccgaac  ctgatgcct  acaccacat  aacctatga  240
atccagaga  ttaaccttt  tgatagttt  gaagcctcg  ggagagcat  tgaccagct  300
gctcttggt  tggctgctc  ctttggccc  tcccatagc  cctccgtca  tgctgtgca  360
tctatttgc  atgctctcg  agttccaca  atacagacc  gctggaaac  cccctcggt  420
gacaacaaa  atttgtttt  catcaacct  tacccagat  atgcagcta  cagcagggc  480
atcctggat  tggtcctct  ttacaactg  aaaacagtg  cagtggtgt  tgaagacag  540
acaggtcta  ttcgtctac  agagctcat  aaagctccc  ccagatata  tattaaaat  600
aaaatccgc  agctgccct  tgggaataa  gatgccaag  ctttactca  ggagatgaa  660
aaaggcaag  agttctatg  gatatttga  tgttcacat  aaacagccg  tgaaatcct  720
aagcagatt  tgttcatgg  catgatgac  gaatactat  actactttt  cacaaccct  780
gacttattt  ctttggatc  ggaactcta  aggtacagt  gcgtaaaca  gaccgggtt  840
gggctgctt  acattgaca  ccctcacgt  tcatccatc  ttgagaagt  gtccatgga  900
agactgcag  ccccaccca  gcccgagac  ggccttttg  atggcatga  gacaactga  960
gcggctctg  tgtacgatg  tgtgtacat  gtggccatt  cctcgcacc  ggcatccca  1020
ctgaccgtc  gctccctgc  gtgccatag  cataagcca  ggcgcctcg  acccagatt  1080
atgaacctg  tcaaagagg  ccggtggga  ggcttgact  ggcatatca  ctttaataa  1140
accaatggc  tgaggaagg  ttttgatct  gacattatt  gtctcaaag  ggaaggaac  1200
gaaaagatt  ggatttgga  ttccaacag  gggcttaac  tgacggaca  caacaaaga  1260
aagtccagc  atatcactg  ttcattggc  aacagaaca  tcattgtca  caccattct  1320
gaagaaccc  atgttatgt  caggaaatc  gataagcct  tatatggaa  tgacagatt  1380
gaaggatat  gcctagacc  gttgaaaga  ttgtcaaac  tcctgggtt  catttatga  1440
gttaaacta  ttcccgatg  caaatatgg  gcccagaat  acaaagggg  gtggaacgg  1500
atggttaaa  aactcatag  tcacagggc  gacctggca  tggctcctc  taccatcac  1560
tacgtgcgg  agaaagtca  tgacttctc  aaacccttc  tgaccctag  catcagcat  1620
ctctaccgg  agcccaatg  taccaatcc  ggcgttttc  ccttcctca  ccccctgtc  1680
ccagatatt  ggatgtatg  gctcttagc  tgcttggga  tcagctgtg  actctttgt  1740
attgcaagg  ttacaccct  cgagtggta  aacccccac  catgcaacc  tgactcaga  1800
gtggtggaa  acaatttta  tttactaaa  agtttctgg  ttggagttg  agctctcat  1860
cagcaagga  cagagctga  gcccaaagc  ctatcgacc  gaatagttg  agggatatg  1920
tggtttttc  ccctaatca  catttcatc  tacacggcc  atctggctg  cttcttgac  1980
gtagagaga  tggaatccc  catagattc  gcagatgat  tggcaaagc  aaccaagat  2040
gaatatggg  cggttagag  tggatcaac  atgaccttc  tcaagaaat  aaaaatctc  2100
acctatgag  agatgtggg  tttcatgag  agcaggcag  agaccgccc  ggtaagaaa  2160
agtgatgag  ggatccaga  agtgctcac  acagactac  cgctgctga  ggagtccac  2220
agcattgag  atgtgacgc  gagaaactg  aacctcact  agatcgggg  cctcattga  2280
tccaaaggt  acggagtgg  aacacctat  ggttctcct  accgggata  aattactat  2340
gctattctt  aactccaag  agaagggaa  ctgcatatg  tgaaagaga  gtggtggcg  2400
gggaatggc  gccccgagg  agacaacaa  gaagccagt  ccctgggag  ggaaaatat  2460
ggaggcatc  tcattgttc  ggctgccgg  ctggtcctt  ctgtatttg  agctattgg  2520
gaattcata  acaaatcac  gaagaataa  gatattgaa  agtgtctct  tttcaacgc  2580
atcatggaa  aactgggaa  ctcactgaa  aatcagaaa  aaataaaga  aaagtcaag  2640
actaagggg  aatcttcct  cacaagtat  cttacttgt  atcagagac  aactcagag  2700
aaagagact  tggcgtga  2718



<210> 3984
<211> 918
<212> PRT
<213> Homo sapiens
<308> P39086
<400> 3984

Met Glu His Gly Thr Leu Leu Ala Gln Pro Gly Leu Trp Thr Arg Asp 
  1               5                  10                  15
Thr Ser Trp Ala Leu Leu Tyr Phe Leu Cys Tyr Ile Leu Pro Gln Thr 
             20                  25                  30
Ala Pro Gln Val Leu Arg Ile Gly Gly Ile Phe Glu Thr Val Glu Asn 
         35                  40                  45
Glu Pro Val Asn Val Glu Glu Leu Ala Phe Lys Phe Ala Val Thr Ser 
     50                  55                  60
Ile Asn Arg Asn Arg Thr Leu Met Pro Asn Thr Thr Leu Thr Tyr Asp 
 65                  70                  75                  80
Ile Gln Arg Ile Asn Leu Phe Asp Ser Phe Glu Ala Ser Arg Arg Ala 
                 85                  90                  95
Cys Asp Gln Leu Ala Leu Gly Val Ala Ala Leu Phe Gly Pro Ser His 
             100                105                110
Ser Ser Ser Val Ser Ala Val Gln Ser Ile Cys Asn Ala Leu Glu Val 
         115                120                125
Pro His Ile Gln Thr Arg Trp Lys His Pro Ser Val Asp Asn Lys Asp 
     130                135                140
Leu Phe Tyr Ile Asn Leu Tyr Pro Asp Tyr Ala Ala Ile Ser Arg Ala 
 145                150                155                160
Ile Leu Asp Leu Val Leu Tyr Tyr Asn Trp Lys Thr Val Thr Val Val 
                 165                170                175
Tyr Glu Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala 
             180                185                190
Pro Ser Arg Tyr Asn Ile Lys Ile Lys Ile Arg Gln Leu Pro Ser Gly 
         195                200                205
Asn Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Lys Gly Lys Glu 
     210                215                220
Phe Tyr Val Ile Phe Asp Cys Ser His Glu Thr Ala Ala Glu Ile Leu 
 225                230                235                240
Lys Gln Ile Leu Phe Met Gly Met Met Thr Glu Tyr Tyr His Tyr Phe 
                 245                250                255
Phe Thr Thr Leu Asp Leu Phe Ala Leu Asp Leu Glu Leu Tyr Arg Tyr 
             260                265                270
Ser Gly Val Asn Met Thr Gly Phe Arg Leu Leu Asn Ile Asp Asn Pro 
         275                280                285
His Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala 
     290                295                300
Pro Pro Arg Pro Glu Thr Gly Leu Leu Asp Gly Met Met Thr Thr Glu 
 305                310                315                320
Ala Ala Leu Met Tyr Asp Ala Val Tyr Met Val Ala Ile Ala Ser His 
                 325                330                335
Arg Ala Ser Gln Leu Thr Val Ser Ser Leu Gln Cys His Arg His Lys 
             340                345                350
Pro Trp Arg Leu Gly Pro Arg Phe Met Asn Leu Ile Lys Glu Ala Arg 
         355                360                365
Trp Asp Gly Leu Thr Gly His Ile Thr Phe Asn Lys Thr Asn Gly Leu 
     370                375                380
Arg Lys Asp Phe Asp Leu Asp Ile Ile Ser Leu Lys Glu Glu Gly Thr 
 385                390                395                400
Glu Lys Ala Ala Gly Glu Val Ser Lys His Leu Tyr Lys Val Trp Lys 
                 405                410                415
Lys Ile Gly Ile Trp Asn Ser Asn Ser Gly Leu Asn Met Thr Asp Ser 
             420                425                430
Asn Lys Asp Lys Ser Ser Asn Ile Thr Asp Ser Leu Ala Asn Arg Thr 
         435                440                445
Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Met Tyr Arg Lys 
     450                455                460
Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Leu 
 465                470                475                480
Asp Leu Leu Lys Glu Leu Ser Asn Ile Leu Gly Phe Ile Tyr Asp Val 
                 485                490                495
Lys Leu Val Pro Asp Gly Lys Tyr Gly Ala Gln Asn Asp Lys Gly Glu 
             500                505                510
Trp Asn Gly Met Val Lys Glu Leu Ile Asp His Arg Ala Asp Leu Ala 
         515                520                525
Val Ala Pro Leu Thr Ile Thr Tyr Val Arg Glu Lys Val Ile Asp Phe 
     530                535                540
Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys Pro 
 545                550                555                560
Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser Pro 
                 565                570                575
Asp Ile Trp Met Tyr Val Leu Leu Ala Cys Leu Gly Val Ser Cys Val 
             580                585                590
Leu Phe Val Ile Ala Arg Phe Thr Pro Tyr Glu Trp Tyr Asn Pro His 
         595                600                605
Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu Leu 
     610                615                620
Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser Glu 
 625                630                635                640
Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp Trp 
                 645                650                655
Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala 
             660                665                670
Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp Asp 
         675                680                685
Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Arg Asp Gly Ser 
     690                695                700
Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Glu Lys Met 
 705                710                715                720
Trp Ala Phe Met Ser Ser Arg Gln Gln Thr Ala Leu Val Arg Asn Ser 
                 725                730                735
Asp Glu Gly Ile Gln Arg Val Leu Thr Thr Asp Tyr Ala Leu Leu Met 
             740                745                750
Glu Ser Thr Ser Ile Glu Tyr Val Thr Gln Arg Asn Cys Asn Leu Thr 
         755                760                765
Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr Pro 
     770                775                780
Ile Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln Leu 
 785                790                795                800
Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg Gly 
                 805                810                815
Asn Gly Cys Pro Glu Glu Asp Asn Lys Glu Ala Ser Ala Leu Gly Val 
             820                825                830
Glu Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val Leu 
         835                840                845
Ser Val Phe Val Ala Ile Gly Glu Phe Ile Tyr Lys Ser Arg Lys Asn 
     850                855                860
Asn Asp Ile Glu Gln Ala Phe Cys Phe Phe Tyr Gly Leu Gln Cys Lys 
 865                870                875                880
Gln Thr His Pro Thr Asn Ser Thr Ser Gly Thr Thr Leu Ser Thr Asp 
                 885                890                895
Leu Glu Cys Gly Lys Leu Ile Arg Glu Glu Arg Gly Ile Arg Lys Gln 
             900                905                910
Ser Ser Val His Thr Val 
         915



<210> 3985
<211> 3185
<212> DNA
<213> Rattus norvegicus
<308> M83561
<400> 3985

ggctaggaa  cccgcttca  gtccccacg  ttgttccct  cacctcgct  tcctgagag  60
agagagcgc  cggtgtgca  actcggagc  ttccgggag  atgaggcgg  gacccagcc  120
aagttgggt  catcttgcg  gcgtgaggc  acaactggg  ttcggcatg  attaagaag  180
ttgaaagat  gagcgcagc  cagtcctta  ccaacccgg  ctctggacc  gggacacca  240
ctggacact  ctctatttc  tgtgctaca  cctccctca  acctcccct  aagtgctca  300
gatcggagg  atttttgaa  ctgtggaaa  tgaacctgt  aatgttgaa  aattagctt  360
caagtttgc  gtcaccagt  ttaaccgaa  ccgaacctt  atgcccaat  ccacattaa  420
ctatgacat  cagagaatt  atctttttg  tagttttga  gcctcccga  gagcatgcg  480
ccagctggc  ctcggggtg  ccgcactct  cggcccttc  cacagctcc  ccgtcagtg  540
tgtacagtc  atttgcaat  ctctggaag  tccacacat  cagactcgc  ggaaacacc  600
ttccgtgga  agcagagac  tattttata  caacctcta  ccggactat  cggctatca  660
cagggcggt  ctggatttg  tcctctatt  caactggaa  acagtgacg  tggtgtatg  720
agatagcac  ggtctaatt  gtctgcaag  gctcatcaa  gctccctcc  gatacaaca  780
taaaatcaa  atccgccag  ttccccctg  gaataaaga  gccaaacct  tgctcaagg  840
gatgaagaa  agcaaagag  tctatgtga  atttgattg  tcgcacgaa  cagctgcgg  900
aattcttaa  cagattttg  tcatgggca  gatgactga  tattatcac  acttcttca  960
aaccctgga  ttgtttgct  tagatctgg  actctatag  tacagcggt  taaatatga  1020
tggatttcg  ttgctgaat  ttgacaacc  tcacgtgtc  tccatcatt  agaagtggt  1080
catggagag  ttgcaggcc  cgcccagac  cgagactgg  cttctggat  gcatgatga  1140
aactgaagc  gcgctgatg  acgatgctg  gtacatggt  gccattgcg  cccaccgtg  1200
ctctcagct  accgtcagc  ccctgcagt  ccatcgaca  aagccatgg  gccttggac  1260
cagatttat  aacctcatc  aagaggctc  gtgggacgg  ttgactggg  ggatcacct  1320
caataagac  gatggcttg  gaaaggatt  tgacctgga  attatcagt  tcaaagagg  1380
aggaactga  aagattggg  tttggaact  caacagtgg  ctgaacatg  cggatggca  1440
cagagacag  tccaacaat  tcacggact  gctggctaa  cgcacactc  ttgtcacca  1500
tattctgga  gagccctac  tgatgtaca  gaaatccga  aagcccttg  atggaaacg  1560
caggtttga  ggatattgc  tggatctgc  gaaagaact  tccaatatc  tgggttttc  1620
ttacgatgt  aaactggtt  ctgatggca  atatggagc  cagaatgac  aaggggaat  1680
gaatgggat  gtaaaagaa  tcatcgacc  cagagctga  ctggcagtg  cccctctca  1740
catcacata  gtacgggag  aagtcattg  cttctccaa  cccttcatg  ccctgggca  1800
tagcatcct  taccggaag  ccaatggaa  caacccggg  gtcttctcc  tcctcaacc  1860
cctatctcc  gacatttgg  tgtacgtgc  gctcgcctg  ctaggagtc  gttgtgtac  1920
gtttgtgat  gcgaggttc  caccctacg  gtggtataa  ccccaccca  gcaaccccg  1980
ctcagacgt  gtggaaaac  atttcactt  gctaaatag  ttctggttt  gagttggag  2040
tctcatgca  caaggatca  agctgatgc  caaggctct  tcgaccaga  tagttggag  2100
aatatggtg  tttttcacc  taatcatca  ttcatccta  acggccaac  tggctgcct  2160
cttgacggt  gaaagaatg  aatccccca  cgattccgc  gacgatctg  ccaaacaaa  2220
caagataga  tatggggca  tcagagatg  ctcgacgat  accttcttc  agaaatcaa  2280
gatctccac  tatgagaaa  tgtgggctt  catgagcag  agacagcag  gcgcactgg  2340
taaaaacag  gacgagggg  tccaaaggg  gctcaccac  gactacgca  tgctgatgg  2400
gtccaccag  attgagtat  tgacgcaga  gaactgcaa  ctcactcag  tcgggggcc  2460
catagactc  aaaggctat  gagtgggga  gcctatcgg  tccccttac  gggataaaa  2520
tacgattgc  attcttcaa  tgcaagaag  agggaagct  catatgatg  aagagaagt  2580
gtggagggg  aatggctgc  ctgaagaag  cagtaagga  gccagtgct  tgggagtgg  2640
aaatatcgg  ggcatcttc  ttgttctgg  tgcaggact  gtgctttct  tgtttgtag  2700
cattggaga  tttttatac  aatcacgga  gaacaatga  gttgagcag  gtctctctt  2760
caatgccat  atggaagag  tgggaatat  cctcaagaa  cagaaaaaa  taaagaaaa  2820
gtcaagaac  aagggcaaa  cttctttca  aagtatcct  acttgtcac  agagacgaa  2880
tcagagaaa  gagacagtg  cgtgatcaa  gaacacacc  gtaagaaga  aaagcccac  2940
cgtccgctg  acatatttg  aggacagat  tcagaggac  atgtcttta  ccataaccc  3000
agtcgtgga  agaggggga  gaaatgcac  atttttaaa  ctcacatag  tattacttg  3060
gaagtgaaa  tgattcttt  cagatgaat  tgtatgcac  cttattttg  atttttcca  3120
ttcctccga  aaattgcta  gtgtgcttt  taaataata  taaacaagc  gactttgtt  3180
ttcat  3185



<210> 3986
<211> 949
<212> PRT
<213> Rattus norvegicus
<308> P22756
<400> 3986

Met Glu Arg Ser Thr Val Leu Ile Gln Pro Gly Leu Trp Thr Arg Asp 
  1               5                  10                  15
Thr Ser Trp Thr Leu Leu Tyr Phe Leu Cys Tyr Ile Leu Pro Gln Thr 
             20                  25                  30
Ser Pro Gln Val Leu Arg Ile Gly Gly Ile Phe Glu Thr Val Glu Asn 
         35                  40                  45
Glu Pro Val Asn Val Glu Glu Leu Ala Phe Lys Phe Ala Val Thr Ser 
     50                  55                  60
Ile Asn Arg Asn Arg Thr Leu Met Pro Asn Thr Thr Leu Thr Tyr Asp 
 65                  70                  75                  80
Ile Gln Arg Ile Asn Leu Phe Asp Ser Phe Glu Ala Ser Arg Arg Ala 
                 85                  90                  95
Cys Asp Gln Leu Ala Leu Gly Val Ala Ala Leu Phe Gly Pro Ser His 
             100                105                110
Ser Ser Ser Val Ser Ala Val Gln Ser Ile Cys Asn Ala Leu Glu Val 
         115                120                125
Pro His Ile Gln Thr Arg Trp Lys His Pro Ser Val Asp Ser Arg Asp 
     130                135                140
Leu Phe Tyr Ile Asn Leu Tyr Pro Asp Tyr Ala Ala Ile Ser Arg Ala 
 145                150                155                160
Val Leu Asp Leu Val Leu Tyr Tyr Asn Trp Lys Thr Val Thr Val Val 
                 165                170                175
Tyr Glu Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala 
             180                185                190
Pro Ser Arg Tyr Asn Ile Lys Ile Lys Ile Arg Gln Leu Pro Pro Ala 
         195                200                205
Asn Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Lys Ser Lys Glu 
     210                215                220
Phe Tyr Val Ile Phe Asp Cys Ser His Glu Thr Ala Ala Glu Ile Leu 
 225                230                235                240
Lys Gln Ile Leu Phe Met Gly Met Met Thr Glu Tyr Tyr His Tyr Phe 
                 245                250                255
Phe Thr Thr Leu Asp Leu Phe Ala Leu Asp Leu Glu Leu Tyr Arg Tyr 
             260                265                270
Ser Gly Val Asn Met Thr Gly Phe Arg Lys Leu Asn Ile Asp Asn Pro 
         275                280                285
His Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala 
     290                295                300
Pro Pro Arg Pro Glu Thr Gly Leu Leu Asp Gly Met Met Thr Thr Glu 
 305                310                315                320
Ala Ala Leu Met Tyr Asp Ala Val Tyr Met Val Ala Ile Ala Ser His 
                 325                330                335
Arg Ala Ser Gln Leu Thr Val Ser Ser Leu Gln Cys His Arg His Lys 
             340                345                350
Pro Cys Ala Leu Gly Pro Arg Phe Met Asn Leu Ile Lys Glu Ala Arg 
         355                360                365
Trp Asp Gly Leu Thr Gly Arg Ile Thr Phe Asn Lys Thr Asp Gly Leu 
     370                375                380
Arg Lys Asp Phe Asp Leu Asp Ile Ile Ser Leu Lys Glu Glu Gly Thr 
 385                390                395                400
Glu Lys Ala Ser Gly Glu Val Ser Lys His Leu Tyr Lys Val Trp Lys 
                 405                410                415
Lys Ile Gly Ile Trp Asn Ser Asn Ser Gly Leu Asn Met Thr Asp Gly 
             420                425                430
Asn Arg Asp Arg Ser Asn Asn Ile Thr Asp Ser Leu Ala Asn Arg Thr 
         435                440                445
Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Met Tyr Arg Lys 
     450                455                460
Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Ala Tyr Cys Leu 
 465                470                475                480
Asp Leu Leu Lys Glu Leu Ser Asn Ile Leu Gly Phe Leu Tyr Asp Val 
                 485                490                495
Lys Leu Val Pro Asp Gly Lys Tyr Gly Ala Gln Asn Asp Lys Gly Glu 
             500                505                510
Trp Asn Gly Met Val Lys Glu Leu Ile Asp His Arg Ala Asp Leu Ala 
         515                520                525
Val Ala Pro Leu Thr Ile Thr Tyr Val Arg Glu Lys Val Ile Asp Phe 
     530                535                540
Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys Pro 
 545                550                555                560
Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser Pro 
                 565                570                575
Asp Ile Trp Met Tyr Val Leu Leu Ala Cys Leu Gly Val Ser Cys Val 
             580                585                590
Leu Phe Val Ile Ala Arg Phe Thr Pro Tyr Glu Trp Tyr Asn Pro His 
         595                600                605
Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu Leu 
     610                615                620
Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser Glu 
 625                630                635                640
Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp Trp 
                 645                650                655
Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala 
             660                665                670
Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp Asp 
         675                680                685
Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Arg Asp Gly Ser 
     690                695                700
Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Glu Lys Met 
 705                710                715                720
Trp Ala Phe Met Ser Ser Arg Gln Gln Ser Ala Leu Val Lys Asn Ser 
                 725                730                735
Asp Glu Gly Ile Gln Arg Val Leu Thr Thr Asp Tyr Ala Leu Leu Met 
             740                745                750
Glu Ser Thr Ser Ile Glu Tyr Val Thr Gln Arg Asn Cys Asn Leu Thr 
         755                760                765
Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr Pro 
     770                775                780
Ile Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln Leu 
 785                790                795                800
Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg Gly 
                 805                810                815
Asn Gly Cys Pro Glu Glu Asp Ser Lys Glu Ala Ser Ala Leu Gly Val 
             820                825                830
Glu Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val Leu 
         835                840                845
Ser Val Phe Val Ala Ile Gly Glu Phe Leu Tyr Lys Ser Arg Lys Asn 
     850                855                860
Asn Asp Val Glu Gln Lys Gly Lys Ser Ser Arg Leu Arg Phe Tyr Phe 
 865                870                875                880
Arg Asn Lys Val Arg Phe His Gly Ser Lys Lys Glu Ser Leu Gly Val 
                 885                890                895
Glu Lys Cys Leu Ser Phe Asn Ala Ile Met Glu Glu Leu Gly Ile Ser 
             900                905                910
Leu Lys Asn Gln Lys Lys Leu Lys Lys Lys Ser Arg Thr Lys Gly Lys 
         915                920                925
Ser Ser Phe Thr Ser Ile Leu Thr Cys His Gln Arg Arg Thr Gln Arg 
     930                935                940
Lys Glu Thr Val Ala 
 945



<210> 3987
<211> 2718
<212> DNA
<213> Homo sapiens
<308> U16125
<400> 3987

atggagcac  gcacactcc  cgcccagcc  gggctctgg  ccagggaca  cagctgggc  60
ctcctctat  tcctctgct  tatcctccc  cagaccgcc  cgcaagtac  caggatcgg  120
gggattttt  aaacagtgg  aaatgagcc  gttaatgtt  aagaattag  tttcaagtt  180
gcagtcacc  gcattaaca  aaaccgaac  ctgatgcct  acaccacat  aacctatga  240
atccagaga  ttaaccttt  tgatagttt  gaagcctcg  ggagagcat  tgaccagct  300
gctcttggt  tggctgctc  ctttggccc  tcccatagc  cctccgtca  tgctgtgca  360
tctatttgc  atgctctcg  agttccaca  atacagacc  gctggaaac  cccctcggt  420
gacaacaaa  atttgtttt  catcaacct  tacccagat  atgcagcta  cagcagggc  480
atcctggat  tggtcctct  ttacaactg  aaaacagtg  cagtggtgt  tgaagacag  540
acaggtcta  ttcgtctac  agagctcat  aaagctccc  ccagatata  tattaaaat  600
aaaatccgc  agctgccct  tgggaataa  gatgccaag  ctttactca  ggagatgaa  660
aaaggcaag  agttctatg  gatatttga  tgttcacat  aaacagccg  tgaaatcct  720
aagcagatt  tgttcatgg  catgatgac  gaatactat  actactttt  cacaaccct  780
gacttattt  ctttggatc  ggaactcta  aggtacagt  gcgtaaaca  gaccgggtt  840
gggctgctt  acattgaca  ccctcacgt  tcatccatc  ttgagaagt  gtccatgga  900
agactgcag  ccccaccca  gcccgagac  ggccttttg  atggcatga  gacaactga  960
gcggctctg  tgtacgatg  tgtgtacat  gtggccatt  cctcgcacc  ggcatccca  1020
ctgaccgtc  gctccctgc  gtgccatag  cataagcca  ggcgcctcg  acccagatt  1080
atgaacctg  tcaaagagg  ccggtggga  ggcttgact  ggcatatca  ctttaataa  1140
accaatggc  tgaggaagg  ttttgatct  gacattatt  gtctcaaag  ggaaggaac  1200
gaaaagatt  ggatttgga  ttccaacag  gggcttaac  tgacggaca  caacaaaga  1260
aagtccagc  atatcactg  ttcattggc  aacagaaca  tcattgtca  caccattct  1320
gaagaaccc  atgttatgt  caggaaatc  gataagcct  tatatggaa  tgacagatt  1380
gaaggatat  gcctagacc  gttgaaaga  ttgtcaaac  tcctgggtt  catttatga  1440
gttaaacta  ttcccgatg  caaatatgg  gcccagaat  acaaagggg  gtggaacgg  1500
atggttaaa  aactcatag  tcacagggc  gacctggca  tggctcctc  taccatcac  1560
tacgtgcgg  agaaagtca  tgacttctc  aaacccttc  tgaccctag  catcagcat  1620
ctctaccgg  agcccaatg  taccaatcc  ggcgttttc  ccttcctca  ccccctgtc  1680
ccagatatt  ggatgtatg  gctcttagc  tgcttggga  tcagctgtg  actctttgt  1740
attgcaagg  ttacaccct  cgagtggta  aacccccac  catgcaacc  tgactcaga  1800
gtggtggaa  acaatttta  tttactaaa  agtttctgg  ttggagttg  agctctcat  1860
cagcaagga  cagagctga  gcccaaagc  ctatcgacc  gaatagttg  agggatatg  1920
tggtttttc  ccctaatca  catttcatc  tacacggcc  atctggctg  cttcttgac  1980
gtagagaga  tggaatccc  catagattc  gcagatgat  tggcaaagc  aaccaagat  2040
gaatatggg  cggttagag  tggatcaac  atgaccttc  tcaagaaat  aaaaatctc  2100
acctatgag  agatgtggg  tttcatgag  agcaggcag  agaccgccc  ggtaagaaa  2160
agtgatgag  ggatccaga  agtgctcac  acagactac  cgctgctga  ggagtccac  2220
agcattgag  atgtgacgc  gagaaactg  aacctcact  agatcgggg  cctcattga  2280
tccaaaggt  acggagtgg  aacacctat  ggttctcct  accgggata  aattactat  2340
gctattctt  aactccaag  agaagggaa  ctgcatatg  tgaaagaga  gtggtggcg  2400
gggaatggc  gccccgagg  agacaacaa  gaagccagt  ccctgggag  ggaaaatat  2460
ggaggcatc  tcattgttc  ggctgccgg  ctggtcctt  ctgtatttg  agctattgg  2520
gaattcata  acaaatcac  gaagaataa  gatattgaa  agtgtctct  tttcaacgc  2580
atcatggaa  aactgggaa  ctcactgaa  aatcagaaa  aaataaaga  aaagtcaag  2640
actaagggg  aatcttcct  cacaagtat  cttacttgt  atcagagac  aactcagag  2700
aaagagact  tggcgtga  2718



<210> 3988
<211> 918
<212> PRT
<213> Homo sapiens
<308> P39086
<400> 3988

Met Glu His Gly Thr Leu Leu Ala Gln Pro Gly Leu Trp Thr Arg Asp 
  1               5                  10                  15
Thr Ser Trp Ala Leu Leu Tyr Phe Leu Cys Tyr Ile Leu Pro Gln Thr 
             20                  25                  30
Ala Pro Gln Val Leu Arg Ile Gly Gly Ile Phe Glu Thr Val Glu Asn 
         35                  40                  45
Glu Pro Val Asn Val Glu Glu Leu Ala Phe Lys Phe Ala Val Thr Ser 
     50                  55                  60
Ile Asn Arg Asn Arg Thr Leu Met Pro Asn Thr Thr Leu Thr Tyr Asp 
 65                  70                  75                  80
Ile Gln Arg Ile Asn Leu Phe Asp Ser Phe Glu Ala Ser Arg Arg Ala 
                 85                  90                  95
Cys Asp Gln Leu Ala Leu Gly Val Ala Ala Leu Phe Gly Pro Ser His 
             100                105                110
Ser Ser Ser Val Ser Ala Val Gln Ser Ile Cys Asn Ala Leu Glu Val 
         115                120                125
Pro His Ile Gln Thr Arg Trp Lys His Pro Ser Val Asp Asn Lys Asp 
     130                135                140
Leu Phe Tyr Ile Asn Leu Tyr Pro Asp Tyr Ala Ala Ile Ser Arg Ala 
 145                150                155                160
Ile Leu Asp Leu Val Leu Tyr Tyr Asn Trp Lys Thr Val Thr Val Val 
                 165                170                175
Tyr Glu Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala 
             180                185                190
Pro Ser Arg Tyr Asn Ile Lys Ile Lys Ile Arg Gln Leu Pro Ser Gly 
         195                200                205
Asn Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Lys Gly Lys Glu 
     210                215                220
Phe Tyr Val Ile Phe Asp Cys Ser His Glu Thr Ala Ala Glu Ile Leu 
 225                230                235                240
Lys Gln Ile Leu Phe Met Gly Met Met Thr Glu Tyr Tyr His Tyr Phe 
                 245                250                255
Phe Thr Thr Leu Asp Leu Phe Ala Leu Asp Leu Glu Leu Tyr Arg Tyr 
             260                265                270
Ser Gly Val Asn Met Thr Gly Phe Arg Leu Leu Asn Ile Asp Asn Pro 
         275                280                285
His Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala 
     290                295                300
Pro Pro Arg Pro Glu Thr Gly Leu Leu Asp Gly Met Met Thr Thr Glu 
 305                310                315                320
Ala Ala Leu Met Tyr Asp Ala Val Tyr Met Val Ala Ile Ala Ser His 
                 325                330                335
Arg Ala Ser Gln Leu Thr Val Ser Ser Leu Gln Cys His Arg His Lys 
             340                345                350
Pro Trp Arg Leu Gly Pro Arg Phe Met Asn Leu Ile Lys Glu Ala Arg 
         355                360                365
Trp Asp Gly Leu Thr Gly His Ile Thr Phe Asn Lys Thr Asn Gly Leu 
     370                375                380
Arg Lys Asp Phe Asp Leu Asp Ile Ile Ser Leu Lys Glu Glu Gly Thr 
 385                390                395                400
Glu Lys Ala Ala Gly Glu Val Ser Lys His Leu Tyr Lys Val Trp Lys 
                 405                410                415
Lys Ile Gly Ile Trp Asn Ser Asn Ser Gly Leu Asn Met Thr Asp Ser 
             420                425                430
Asn Lys Asp Lys Ser Ser Asn Ile Thr Asp Ser Leu Ala Asn Arg Thr 
         435                440                445
Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Met Tyr Arg Lys 
     450                455                460
Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Leu 
 465                470                475                480
Asp Leu Leu Lys Glu Leu Ser Asn Ile Leu Gly Phe Ile Tyr Asp Val 
                 485                490                495
Lys Leu Val Pro Asp Gly Lys Tyr Gly Ala Gln Asn Asp Lys Gly Glu 
             500                505                510
Trp Asn Gly Met Val Lys Glu Leu Ile Asp His Arg Ala Asp Leu Ala 
         515                520                525
Val Ala Pro Leu Thr Ile Thr Tyr Val Arg Glu Lys Val Ile Asp Phe 
     530                535                540
Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys Pro 
 545                550                555                560
Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser Pro 
                 565                570                575
Asp Ile Trp Met Tyr Val Leu Leu Ala Cys Leu Gly Val Ser Cys Val 
             580                585                590
Leu Phe Val Ile Ala Arg Phe Thr Pro Tyr Glu Trp Tyr Asn Pro His 
         595                600                605
Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu Leu 
     610                615                620
Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser Glu 
 625                630                635                640
Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp Trp 
                 645                650                655
Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala 
             660                665                670
Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp Asp 
         675                680                685
Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Arg Asp Gly Ser 
     690                695                700
Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Glu Lys Met 
 705                710                715                720
Trp Ala Phe Met Ser Ser Arg Gln Gln Thr Ala Leu Val Arg Asn Ser 
                 725                730                735
Asp Glu Gly Ile Gln Arg Val Leu Thr Thr Asp Tyr Ala Leu Leu Met 
             740                745                750
Glu Ser Thr Ser Ile Glu Tyr Val Thr Gln Arg Asn Cys Asn Leu Thr 
         755                760                765
Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr Pro 
     770                775                780
Ile Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln Leu 
 785                790                795                800
Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg Gly 
                 805                810                815
Asn Gly Cys Pro Glu Glu Asp Asn Lys Glu Ala Ser Ala Leu Gly Val 
             820                825                830
Glu Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val Leu 
         835                840                845
Ser Val Phe Val Ala Ile Gly Glu Phe Ile Tyr Lys Ser Arg Lys Asn 
     850                855                860
Asn Asp Ile Glu Gln Ala Phe Cys Phe Phe Tyr Gly Leu Gln Cys Lys 
 865                870                875                880
Gln Thr His Pro Thr Asn Ser Thr Ser Gly Thr Thr Leu Ser Thr Asp 
                 885                890                895
Leu Glu Cys Gly Lys Leu Ile Arg Glu Glu Arg Gly Ile Arg Lys Gln 
             900                905                910
Ser Ser Val His Thr Val 
         915



<210> 3990
<211> 134
<212> PRT
<213> Rattus norvegicus
<308> P35280
<400> 3990

Ile Thr Thr Ala Tyr Tyr Arg Gly Ala Met Gly Ile Met Leu Val Tyr 
  1               5                  10                  15
Asp Ile Thr Asn Glu Lys Ser Phe Asp Asn Ile Arg Asn Ser Ile Arg 
             20                  25                  30
Asn Ile Glu Glu His Ala Ser Ala Asp Val Glu Lys Met Ile Leu Gly 
         35                  40                  45
Asn Lys Cys Asp Val Asn Asp Lys Arg Gln Val Ser Lys Glu Arg Gly 
     50                  55                  60
Glu Lys Leu Ala Leu Asp Tyr Gly Ile Lys Phe Met Glu Thr Ser Ala 
 65                  70                  75                  80
Lys Ala Asn Ile Asn Val Glu Asn Ala Phe Phe Thr Leu Ala Arg Asp 
                 85                  90                  95
Ile Lys Ala Lys Met Asp Lys Asn Trp Asn Pro Thr Thr Leu Arg Ser 
             100                105                110
Ser His Gly Val Lys Ile Thr Val Glu Gln Gln Lys Arg Arg Ser Phe 
         115                120                125
Phe Arg Cys Ser Leu Leu 
     130



<210> 3992
<211> 207
<212> PRT
<213> Homo sapiens
<308> P24407
<400> 3992

Met Ala Lys Thr Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp 
  1               5                  10                  15
Ser Gly Val Gly Lys Thr Cys Val Leu Phe Arg Phe Ser Glu Asp Ala 
             20                  25                  30
Phe Asn Ser Thr Phe Ile Ser Thr Ile Gly Ile Asp Phe Lys Ile Arg 
         35                  40                  45
Thr Ile Glu Leu Asp Gly Lys Arg Ile Lys Leu Gln Ile Trp Asp Thr 
     50                  55                  60
Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly 
 65                  70                  75                  80
Ala Met Gly Ile Met Leu Val Tyr Asp Ile Thr Asn Glu Lys Ser Phe 
                 85                  90                  95
Asp Asn Ile Arg Asn Trp Ile Arg Asn Ile Glu Glu His Ala Ser Ala 
             100                105                110
Asp Val Glu Lys Met Ile Leu Gly Asn Lys Cys Asp Val Asn Asp Lys 
         115                120                125
Arg Gln Val Ser Lys Glu Arg Gly Glu Lys Leu Ala Leu Asp Tyr Gly 
     130                135                140
Ile Lys Phe Met Glu Thr Ser Ala Lys Ala Asn Ile Asn Val Glu Asn 
 145                150                155                160
Ala Phe Phe Thr Leu Ala Arg Asp Ile Lys Ala Lys Met Asp Lys Lys 
                 165                170                175
Leu Glu Gly Asn Ser Pro Gln Gly Ser Asn Gln Gly Val Lys Ile Thr 
             180                185                190
Pro Asp Gln Gln Lys Arg Ser Ser Phe Phe Arg Cys Val Leu Leu 
         195                200                205



<210> 3993
<211> 857
<212> DNA
<213> Rattus norvegicus
<308> M83678
<400> 3993

accatcgga  ttgatttca  gatccgaac  gtggaaata  aggggaaga  aatcaaact  60
caagtctgg  acacagctg  ccaagaacg  ttcaagaca  taaccacct  ctattaccg  120
ggagccatg  gcattatcc  agtatatga  atcacagat  agaaatcct  cgagaatat  180
cagaactgg  tgaaaagca  caaagagaa  gcgtctgct  aagtggagc  ccttctgct  240
gggaacaaa  gtgacatgg  agccaagcg  aaggtgcag  gagagcagg  tgagaggtt  300
gcccgagag  acagaatcc  attttttga  acaagtgcc  aatccagtg  gaatgtgga  360
gaggctttc  gttccctgg  ccgtgacat  ttgctcaag  caggaggcc  gagatcggg  420
aacagcagc  agccctcaa  cactgacct  aaagtatct  acaagaaga  cagcaacaa  480
tgctccttg  gctgaggga  atttcttgc  tcctattca  cctgaacct  gaggctaga  540
ctgagggag  tggactgag  tagactgat  gaaaacaga  gggaggagc  gtggtggtg  600
ctggagggg  ggatgacag  ggaggaagg  aagatgaaa  gggcaggga  aggagggcg  660
ggaaccaag  acgtgaaaa  tgaagagaa  gggtttgag  agagaaaaa  aagaaggtc  720
caggtctcg  accgtccaa  attaatgtc  gtatgctga  ctctccatt  ctggttcag  780
gttcgggtc  cgagaggct  gctcggccc  actctgagg  tctctcact  cacagatgt  840
tgttagtat  aaaggcc  857



<210> 3994
<211> 164
<212> PRT
<213> Rattus norvegicus
<308> P35286
<400> 3994

Thr Ile Gly Ile Asp Phe Lys Ile Arg Thr Val Glu Ile Glu Gly Lys 
  1               5                  10                  15
Arg Ile Lys Leu Gln Val Trp Asp Thr Ala Gly Gln Glu Arg Phe Lys 
             20                  25                  30
Thr Ile Thr Thr Ser Tyr Tyr Arg Gly Ala Met Gly Ile Ile Leu Val 
         35                  40                  45
Tyr Asp Ile Thr Asp Glu Lys Ser Phe Glu Asn Ile Gln Asn Trp Met 
     50                  55                  60
Lys Ser Ile Lys Glu Asn Ala Ser Ala Glu Val Glu Arg Leu Leu Leu 
 65                  70                  75                  80
Gly Asn Lys Cys Asp Met Glu Ala Lys Arg Lys Val Gln Arg Glu Gln 
                 85                  90                  95
Ala Glu Arg Leu Ala Arg Glu His Arg Ile Arg Phe Phe Glu Thr Ser 
             100                105                110
Ala Lys Ser Ser Val Asn Val Asp Glu Ala Phe Ser Ser Leu Ala Arg 
         115                120                125
Asp Ile Leu Leu Lys Thr Gly Gly Arg Arg Ser Gly Asn Ser Ser Lys 
     130                135                140
Pro Ser Ser Thr Asp Leu Lys Val Ser Asp Lys Lys Asn Ser Asn Lys 
 145                150                155                160
Cys Ser Leu Gly 
                 165



<210> 3995
<211> 1238
<212> DNA
<213> Homo sapiens
<308> X75593
<400> 3995

gaattcgag  atccgggta  catgggagg  aaacttctt  ctggcctgg  ctccgtgcc  60
ctctgtttg  caaccgtcc  gtcccgcct  ccagtgccg  gcgctcccc  cccctcccc  120
ggctccccc  gtgtccgcc  tggccaaag  ctacgacca  ctcttcaag  tgctgctga  180
cggggactc  ggggtgggc  agacttgtc  gatcattcg  tttgcagag  acaacttca  240
caacactta  atctccacc  tcggaattg  tttcaagat  cgcactgtg  atatagagg  300
gaagaagat  aaactacaa  tctgggaca  ggctggcca  gagcggttc  agacaataa  360
tactgccta  taccgtgga  ccatgggca  tatcctagt  tacgacatc  cggatgaga  420
atctttcga  aatattcag  actggatga  aagcatcaa  gagaatgcc  cggctgggg  480
ggagcgcct  ttgctgggg  acaaatgtg  catggaggc  aagaggaag  tgcagaagg  540
gcaggccga  aagttggct  gagagcatg  aatccgatt  ttcgaaact  gtgctaaat  600
cagtatgaa  gtggatgag  cttttagtt  cctggcccg  gacatcttg  tcaagtcag  660
aggccggag  tcaggaaac  gcaacaagc  tcccagtac  gacctgaaa  cttgtgaca  720
gaagaacac  aacaagtgc  ccctgggct  aggaccctt  cttgcctcc  caccccgga  780
gctgaacct  agggagaca  cggcagagg  agtgagcag  ggagaaata  cagaggggc  840
tggagggtc  cataggtag  tggtaaaga  aatgaggag  aaaaggaga  aagggaaaa  900
cagaaagga  aaaaaggaa  agagaggaa  ggagaaggg  gaggaatga  ttgaggaag  960
gaaagaagg  aaggaggta  gaagagagg  aggaggaaa  gaaggagag  gatgcctca  1020
gcttcagac  ttacctggg  tttcagggc  aacataaat  taaatacac  gatttattc  1080
gttactaga  caggtttta  ggtcctgca  aaggctagc  cggcactac  ctagggaat  1140
tgctcctgt  ctgtcactt  tcatggtct  tcttggtat  aaaggccac  atttgcaca  1200
aaaaaaaaa  aaaccatgg  acccggatc  tcgaattc  1238



<210> 3996
<211> 203
<212> PRT
<213> Homo sapiens
<308> P51153
<400> 3996

Met Ala Lys Ala Tyr Asp His Leu Phe Lys Leu Leu Leu Ile Gly Asp 
  1               5                  10                  15
Ser Gly Val Gly Lys Thr Cys Leu Ile Ile Arg Phe Ala Glu Asp Asn 
             20                  25                  30
Phe Asn Asn Thr Tyr Ile Ser Thr Ile Gly Ile Asp Phe Lys Ile Arg 
         35                  40                  45
Thr Val Asp Ile Glu Gly Lys Lys Ile Lys Leu Gln Val Trp Asp Thr 
     50                  55                  60
Ala Gly Gln Glu Arg Phe Lys Thr Ile Thr Thr Ala Tyr Tyr Arg Gly 
 65                  70                  75                  80
Ala Met Gly Ile Ile Leu Val Tyr Asp Ile Thr Asp Glu Lys Ser Phe 
                 85                  90                  95
Glu Asn Ile Gln Asn Trp Met Lys Ser Ile Lys Glu Asn Ala Ser Ala 
             100                105                110
Gly Val Glu Arg Leu Leu Leu Gly Asn Lys Cys Asp Met Glu Ala Lys 
         115                120                125
Arg Lys Val Gln Lys Glu Gln Ala Asp Lys Leu Ala Arg Glu His Gly 
     130                135                140
Ile Arg Phe Phe Glu Thr Ser Ala Lys Ser Ser Met Asn Val Asp Glu 
 145                150                155                160
Ala Phe Ser Ser Leu Ala Arg Asp Ile Leu Leu Lys Ser Gly Gly Arg 
                 165                170                175
Arg Ser Gly Asn Gly Asn Lys Pro Pro Ser Thr Asp Leu Lys Thr Cys 
             180                185                190
Asp Lys Lys Asn Thr Asn Lys Cys Ser Leu Gly 
         195                200



<210> 3997
<211> 945
<212> DNA
<213> Rattus norvegicus
<308> M83679
<400> 3997

gaattcccc  gaatccgga  tggcggaga  gggcgccgc  aggcgtcca  tgcggtaac  60
cgaccgatc  cggagaagc  ggcgggagc  ccggggaga  ttctctttt  tttgtgaag  120
gcagggcgc  ctggggcgg  ctccggccg  gatggcaga  gctgagcgg  gctgagccc  180
cagccgcct  cagccttcg  gcccccttg  gtccctgcc  tggcgaaac  gtacgatgt  240
ctatttcgg  tactgctga  cggggactc  ggggtgggc  agacctgcc  gctatgccg  300
ttcaccgac  acgagttcc  ctcctcgca  atctccacc  tcggtgttg  ctttaagat  360
aaaaccatc  aagtagacg  catcaaagt  aggatacag  tttgggaca  agcagggca  420
gagaggtac  agactatca  aaaacagta  taccggcga  cccagggaa  atttttagt  480
tacgacatt  gcagcgagc  ctcttatca  cacatcatg  agtgggtca  tgacgtgga  540
gagtacgcc  cagaaggcg  ccagaagat  ctcatcggg  ataaggctg  cgaagaaca  600
aaacggcag  tggggagag  gcaagggca  cagctggct  aggagtatg  catggactt  660
tacgaaaca  gtgcctgca  caaccttaa  attaaagag  ccttcactc  tctgaccga  720
ctggtgctg  aggctcaca  gaaagagct  gatggtctc  gaacatgtg  cagcaatga  780
ctcgcactg  ccgagctgg  ggaagacga  ggcaaaact  aaggcccag  aaactcttc  840
aagacctgc  ggtgctgag  gtcctgtgt  gaatcctcc  tcccccagt  cccttccct  900
aggagcccc  tggaggcag  gagtctggc  tttgtcatc  ctgtc  945



<210> 3998
<211> 212
<212> PRT
<213> Rattus norvegicus
<308> AAA41995
<400> 3998

Met Ala Lys Gln Tyr Asp Val Leu Phe Arg Leu Leu Leu Ile Gly Asp 
  1               5                  10                  15
Ser Gly Val Gly Lys Thr Cys Leu Leu Cys Arg Phe Thr Asp Asn Glu 
             20                  25                  30
Phe His Ser Ser His Ile Ser Thr Ile Gly Val Asp Phe Lys Met Lys 
         35                  40                  45
Thr Ile Glu Val Asp Gly Ile Lys Val Arg Ile Gln Ile Trp Asp Thr 
     50                  55                  60
Ala Gly Gln Glu Arg Tyr Gln Thr Ile Thr Lys Gln Tyr Tyr Arg Arg 
 65                  70                  75                  80
Ala Gln Gly Ile Phe Leu Val Tyr Asp Ile Ser Ser Glu Arg Ser Tyr 
                 85                  90                  95
Gln His Ile Met Lys Trp Val Ser Asp Val Asp Glu Tyr Ala Pro Glu 
             100                105                110
Gly Val Gln Lys Ile Leu Ile Gly Asn Lys Ala Asp Glu Glu Gln Lys 
         115                120                125
Arg Gln Val Gly Arg Glu Gln Gly Gln Gln Leu Ala Lys Glu Tyr Gly 
     130                135                140
Met Asp Phe Tyr Glu Thr Ser Ala Cys Thr Asn Leu Asn Ile Lys Glu 
 145                150                155                160
Ser Phe Thr Arg Leu Thr Glu Leu Val Leu Gln Ala His Arg Lys Glu 
                 165                170                175
Leu Asp Gly Leu Arg Thr Cys Ala Ser Asn Glu Leu Ala Leu Ala Glu 
             180                185                190
Leu Glu Glu Asp Glu Gly Lys Thr Glu Gly Pro Ala Asn Ser Ser Lys 
         195                200                205
Thr Cys Trp Cys 
     210



<210> 3999
<211> 1889
<212> DNA
<213> Rattus norvegicus
<308> M83681
<400> 3999

atgttcaaa  tgcttttga  cgggaacag  agcgtaggc  agacctcct  cctgttccg  60
tatgccgat  actccttca  ccccgcctt  gtgagcaca  tgggcattg  cttcaaggt  120
aagacagtc  acagacatg  caagaggat  aagctgcag  tctgggaca  agcaggcca  180
gagcgctac  ggacaatca  cacggccta  taccgtgga  ccatgggct  cctgctgat  240
tatgacatc  ccaaccagg  gtccttcac  gctgtgcag  actgggcta  gcagattaa  300
acctattcc  gggacaacg  ccaggtcat  cttgtgggg  acaagtgtg  cctggagga  360
gaacgggtc  tatctgctg  ggatggcca  aggctcgct  gtgatcttg  ttttgagtt  420
ttcgaggcc  gcgccaagg  gaacatcaa  gtgaagcag  tgttcgagc  cctggtgga  480
atcatctgt  acaagatga  tgagtccct  gaacccagc  ccagcccag  cagcaatgg  540
aaaggccca  ccctcgggg  taccccacc  cctcagccg  gcagctgcg  ctgttaggt  600
cggcccttg  cctccccac  cctctcctt  ttgcctctt  atgggcagc  gccaaggtg  660
cagctatgg  gactgtctc  aagctcagg  caccccctt  cctctggtc  acgtacccc  720
cctcttgca  aagttcagc  ccctttctc  ccatgtcag  atgctcaga  agtcctggt  780
agagcccac  ccccggggc  ctgctcagc  ttgtctggg  ttggcacac  cacacaggc  840
ttcaatgga  gtagctgta  gtgccatgg  ctttcctga  gatggaagg  tgtcccatg  900
cttccgcct  agaaccatt  cccaggtgt  tgatctact  ctctgttgt  ggctgaaga  960
gtcacctgg  gtgggtcgc  gtccaactt  gtcctggta  cctctccat  tcaggtcca  1020
cagtttggc  ttgaaatct  cctatgaac  ggccgctgc  aaggataca  gcagatctg  1080
catctccat  tctgcctct  tggcatcga  tggaaagcc  gctttcccg  tatagaggg  1140
tagagtcag  gcccctgac  cccgggact  tccaaagtg  ccttccaag  ttctcctga  1200
tccatgcca  tccccagaa  taaattttg  attattcag  gccctatcc  tggaggctg  1260
gaattgcct  accctttac  gtacagctt  ctgtcagtt  acctcagag  cagggaact  1320
aggctgccc  gccaggtcc  catctgtcc  gtgttttaa  caacacttt  gcaaacctt  1380
catcctgtg  agaaacgga  gtgaagaaa  caacccaca  agggcgtgc  cttgctagt  1440
ggtttctca  cgcaccatt  gggcttctc  acccgagga  tcatgtata  acccaccgt  1500
ggcatcatt  tcaccatca  ttggcccag  gacactggg  ttgtgggga  ggattgggg  1560
gaaggcatc  gtgggcaac  cagtgtttt  gtttgtaca  catgggagc  acaggccct  1620
ctgtgagtt  gggatgggc  tcgggtgtg  ttgatgtct  tacaaagct  gagacttag  1680
ccctaggat  ctctactca  tccgctagg  agtcttttg  ctcaccgac  aaactcccc  1740
aaacgccat  tgacatgct  ggtccaggt  acagtcggt  gctcagagt  agagtcaca  1800
acccctgat  ctgtatcag  gtgtcctcc  tcagtcccc  gagccaaaa  gattctgca  1860
ccctactga  cacagcctc  tcctggggt  1889



<210> 4000
<211> 219
<212> PRT
<213> Rattus norvegicus
<308> Q63942
<400> 4000

Met Ala Ser Ala Ser Glu Pro Pro Ala Ser Pro Arg Asp Ala Ala Asp 
  1               5                  10                  15
Gln Asn Phe Asp Tyr Met Phe Lys Leu Leu Leu Ile Gly Asn Ser Ser 
             20                  25                  30
Val Gly Lys Thr Ser Phe Leu Phe Arg Tyr Ala Asp Asp Ser Phe Thr 
         35                  40                  45
Pro Ala Phe Val Ser Thr Val Gly Ile Asp Phe Lys Val Lys Thr Val 
     50                  55                  60
Tyr Arg His Asp Lys Arg Ile Lys Leu Gln Ile Trp Asp Thr Ala Gly 
 65                  70                  75                  80
Gln Glu Arg Tyr Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly Ala Met 
                 85                  90                  95
Gly Phe Leu Leu Met Tyr Asp Ile Ala Asn Gln Glu Ser Phe Thr Ala 
             100                105                110
Val Gln Asp Trp Ala Thr Gln Ile Lys Thr Tyr Ser Trp Asp Asn Ala 
         115                120                125
Gln Val Ile Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val 
     130                135                140
Val Ser Ala Glu Asp Gly Gln Arg Leu Ala Gly Asp Leu Gly Phe Glu 
 145                150                155                160
Phe Phe Glu Ala Ser Ala Lys Glu Asn Ile Asn Val Lys Gln Val Phe 
                 165                170                175
Glu Arg Leu Val Asp Ile Ile Cys Asp Lys Met Asn Glu Ser Leu Glu 
             180                185                190
Pro Ser Ser Ser Pro Gly Ser Asn Gly Lys Gly Pro Ala Leu Gly Asp 
         195                200                205
Thr Pro Pro Pro Gln Pro Ser Ser Cys Gly Cys 
     210                215



<210> 4001
<211> 1904
<212> DNA
<213> Homo sapiens
<308> NM_004283
<400> 4001

gcccgcgcg  gatccgggt  gctgcaggc  gctggcttc  gcggctgcg  ggtcggggt  60
gcggccagg  ccaagccgc  gcgagttca  aggcggaac  cctgcaggc  gcgccccct  120
cgcgaggtc  cccctggga  ggagcgcag  ccacccggc  cctccgcat  cgagcagga  180
gcccgtctc  tctccctga  gatttcagg  ctccctgtc  caggaggct  gtgccaaga  240
ggcatcagc  ggagacacc  aggcaggcc  acgggatgc  gcagatcag  acttcgact  300
tatgttcaa  ctgctactg  taggcaaca  cagtgtggg  aagacttcc  tcctgttcc  360
atacgcgga  gactccttc  ctcccgcct  cgtcagtac  gtgggcatc  atttcaagg  420
caagaccgt  taccgccat  acaagagga  caagctgca  atctgggac  cagcgggcc  480
ggagcgcta  cgcaccatc  ccacggcct  ctaccgggg  gccatgggc  tcctgctca  540
gtatgacat  gccaatcag  aatcctttg  cgctgtgca  gactgggcc  cgcaaatca  600
gacctactc  tgggacaac  cccaggtca  cctggtggg  aacaagtgt  acctggagg  660
cgaacgtgt  gtgcctgct  aggatggcc  gaggctcgc  gacgacctt  gtttcgagt  720
ctttgaagc  agtgccaag  agaacatca  tgtgaagca  gtcttcgag  gcctggtgg  780
tgtcatctg  gagaagatg  acgagtccc  ggaacccag  tccagctca  gcagcaacg  840
gaaaggccc  gccgtgggg  atgctccag  cccccagcc  agcagctgc  gctgctaga  900
atggccccc  accccccac  cacccctct  ctgcctcgg  agggactgt  atcgaggcg  960
gagccacag  ggttatctc  aagctcagg  caatccctt  cctcctgtc  actgctccc  1020
gactcctgc  tggctcatt  cttcacaat  tcgccgtgg  tgccaggtt  ctcaggcag  1080
cccggtggg  ggctgcgga  catggggac  cagctctgc  tggcaggca  aggcccagg  1140
acactgacg  gcatgagct  gctgctttc  agggtgtgt  gagggtggc  atgggtgac  1200
cgtcccact  tttctgatg  aggggcatc  gtggtgcct  ctagcttag  accattttc  1260
aggtctctt  tgggttggg  aggactgat  ttcccaagc  ggtggaaga  ggttcatct  1320
cctcgcaca  tgtgggttc  tggagttca  ccagggaag  cggcgcctc  ttctcaggt  1380
ctgcaggct  gtctctgag  ctgccccca  gaactttct  gattccaag  tgggatggt  1440
atccctttg  cccctgcag  ccctctact  gcgaaaagc  gcattgaag  agccttttc  1500
cattgtaga  gggacaggg  gtcagatcc  ctcaacccc  cggcttcag  gaccccaga  1560
gtgccttcc  agcttcccc  aagatccac  tcacccacg  ccctgccac  gtttttgct  1620
tgttcacca  atctctgat  ctgaagtga  ttctggaac  atggaccac  ttagactgg  1680
cagagattc  cccaacccc  agcactccg  ctctgggct  tcggccaga  gttaattaa  1740
ctcagagcc  ggagcctgg  gctggggcc  ccctcccag  ccctgttta  ctgtttagc  1800
ggttgtgtt  taagcaagt  cttgcccaa  catgcatcc  gctagaaaa  gaaatgaag  1860
aacgttccc  gccaccgca  aaaaaaaaa  aaaaaaaaa  aaaa  1904



<210> 4002
<211> 219
<212> PRT
<213> Homo sapiens
<308> O95716
<400> 4002

Met Ala Ser Ala Gly Asp Thr Gln Ala Gly Pro Arg Asp Ala Ala Asp 
  1               5                  10                  15
Gln Asn Phe Asp Tyr Met Phe Lys Leu Leu Leu Ile Gly Asn Ser Ser 
             20                  25                  30
Val Gly Lys Thr Ser Phe Leu Phe Arg Tyr Ala Asp Asp Ser Phe Thr 
         35                  40                  45
Pro Ala Phe Val Ser Thr Val Gly Ile Asp Phe Lys Val Lys Thr Val 
     50                  55                  60
Tyr Arg His Asp Lys Arg Ile Lys Leu Gln Ile Trp Asp Thr Ala Gly 
 65                  70                  75                  80
Gln Glu Arg Tyr Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly Ala Met 
                 85                  90                  95
Gly Phe Leu Leu Met Tyr Asp Ile Ala Asn Gln Glu Ser Phe Ala Ala 
             100                105                110
Val Gln Asp Trp Ala Thr Gln Ile Lys Thr Tyr Ser Trp Asp Asn Ala 
         115                120                125
Gln Val Ile Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val 
     130                135                140
Val Pro Ala Glu Asp Gly Arg Arg Leu Ala Asp Asp Leu Gly Phe Glu 
 145                150                155                160
Phe Phe Glu Ala Ser Ala Lys Glu Asn Ile Asn Val Lys Gln Val Phe 
                 165                170                175
Glu Arg Leu Val Asp Val Ile Cys Glu Lys Met Asn Glu Ser Leu Glu 
             180                185                190
Pro Ser Ser Ser Ser Gly Ser Asn Gly Lys Gly Pro Ala Val Gly Asp 
         195                200                205
Ala Pro Ala Pro Gln Pro Ser Ser Cys Ser Cys 
     210                215



<210> 4003
<211> 949
<212> DNA
<213> Rattus norvegicus
<308> M83740
<400> 4003

gaattccgg  tttatagca  ggacattac  ttttcaggt  cctaaagtc  aaattcaac  60
cactgatat  aaacttcta  ttaaaccaa  agggttctg  tatgatatt  atctgttca  120
agtaacatt  acaaaaaga  gcagaggca  ggggatctc  gccccgccc  cgcggtggc  180
tgctgcctg  cagccgctc  ccctcgctg  cgccacctg  ttcccgcac  ggacatggc  240
ggcaaggca  acaggctga  tgctgagga  cgggaccag  tgctgccaa  cctgcgggc  300
gtggggtgg  atgaactgg  aggccgaga  gccatcttc  aacagttcc  ttttaaaga  360
ttcaacagg  cttttggct  catgacaag  gtcgccctg  aggctgaaa  gctggacca  420
catcccgag  ggtttaacg  gtacaacaa  gtccatatc  ccttgagca  ccacgaatg  480
gccggtctt  ctgaacggg  tataaacct  gccagcttc  tcgaacaag  tgccgtgtc  540
atgacatag  tctaccctg  ctcctattt  cttagggga  aggagaagg  gtgactgga  600
gaggaaccc  gggagggaa  caaggaggc  ggcccttgc  ccctgactc  tgcggtgac  660
accatctcc  tcaggaggg  tatgagtcc  tccctgtgc  gaacgatgc  catgttcct  720
gtgccagcc  cctcactgg  ctctgccat  tttataatt  gaataagct  tcccatttt  780
tatagagtt  ctagcctca  ttgtgtccc  ggctgcctc  tgctccttg  ctaccggtt  840
tagttaatt  tccaagtag  tgtgataaa  catgacaga  agtccaatt  agaccctac  900
aaaacaaac  ccaatatat  atggaaaca  tgcttttat  ccggaattc  949



<210> 4004
<211> 103
<212> PRT
<213> Rattus norvegicus
<308> CAA06587
<400> 4004

Ala Gly Lys Ala His Arg Leu Ser Ala Glu Glu Arg Asp Gln Leu Leu 
  1               5                  10                  15
Pro Asn Leu Arg Ala Val Gly Trp Asn Glu Leu Glu Gly Arg Asp Ala 
             20                  25                  30
Ile Phe Lys Gln Phe His Phe Lys Asp Phe Asn Arg Ala Phe Gly Phe 
         35                  40                  45
Met Thr Arg Val Ala Leu Gln Ala Glu Lys Leu Asp His His Pro Glu 
     50                  55                  60
Trp Phe Asn Val Tyr Asn Lys Val His Ile Thr Leu Ser Thr His Glu 
 65                  70                  75                  80
Cys Ala Gly Leu Ser Glu Arg Asp Ile Asn Leu Ala Ser Phe Ile Glu 
                 85                  90                  95
Gln Val Ala Val Ser Met Thr 
             100



<210> 4005
<211> 624
<212> DNA
<213> Homo sapiens
<308> NM_000281
<400> 4005

cacctgctg  cgcccgcgc  atggctggc  aagcacaca  gctgagcgc  gaggagagg  60
accagctgc  gccaaacct  agggctgtg  ggtggaatg  gctggaagg  cgtgatgcc  120
tcttcaagc  gtttcattt  aaagacttc  acagggcct  tgggttcat  acaagagtg  180
ccctgcagg  tgagaaact  gaccaccat  ctgaatggt  taacgtgta  aacaaggtc  240
acatcacgc  gagcaccca  gagtgtgcc  gcctttcag  acgggacat  aacctggcc  300
gcttcatcg  acaagtagc  gtgtccatg  catagaccc  gcccttcct  tttgaattc  360
tccggggga  ggggtgact  aactgggag  ccagggagg  agctgagga  cccttaccc  420
cccaccact  ccctcccaa  acccagccg  cgccgttga  ggctgagtc  ttgctgtgg  480
atgtgccag  gtccccacc  acaccagga  tttagacct  ttccctgca  cactctctt  540
atcctgggg  ctctgttac  ctaatttga  taaactctc  cctttcttt  caacttccc  600
gcaacaata  tgattttct  gcca  624



<210> 4006
<211> 103
<212> PRT
<213> Homo sapiens
<308> P80095
<400> 4006

Ala Gly Lys Ala His Arg Leu Ser Ala Glu Glu Arg Asp Gln Leu Leu 
  1               5                  10                  15
Pro Asn Leu Arg Ala Val Gly Trp Asn Glu Leu Glu Gly Arg Asp Ala 
             20                  25                  30
Ile Phe Lys Gln Phe His Phe Lys Asp Phe Asn Arg Ala Phe Gly Phe 
         35                  40                  45
Met Thr Arg Val Ala Leu Gln Ala Glu Lys Leu Asp His His Pro Glu 
     50                  55                  60
Trp Phe Asn Val Tyr Asn Lys Val His Ile Thr Leu Ser Thr His Glu 
 65                  70                  75                  80
Cys Ala Gly Leu Ser Glu Arg Asp Ile Asn Leu Ala Ser Phe Ile Glu 
                 85                  90                  95
Gln Val Ala Val Ser Met Thr 
             100



<210> 4007
<211> 2428
<212> DNA
<213> Rattus norvegicus
<308> M83746
<400> 4007

acacacact  gctctttct  tcgggtaca  acagctccg  acattcgca  ccctgccag  60
cagccgggc  gcgcgactc  acggcttcc  tggcagcca  ctgctggtg  acagcgcac  120
gatttgctg  ttgccaagc  tctcttctg  ctcttttgc  acacaaaga  tttttaaaa  180
aagaaaaac  gaaacaaaa  ctacatacc  attttttat  tgcatcttc  ctcttcttc  240
cctgctcca  caccctgcg  gcctcgcag  cccactttt  actcccaaa  aaggatgga  300
ggcggttgt  gatctcagt  gaaggcggc  gggcttctc  tctgtgtca  ggtttttgc  360
tctgccgag  gaccggtct  cacgaatca  tttcttgtg  agttgcata  agacggaga  420
gaagaggct  gccaagttg  agcagaaca  ggatttgga  tccgaaagc  cccctttgc  480
gaaggcctg  accactttt  ccacaatgg  cttgcgaag  ccaaaagaa  acgcagcct  540
catcacaag  ggcagctgg  gagagaccc  aggataaag  tggccctgc  gcaagaagg  600
tttgaccgt  aaaagagag  gtacagaga  atcaatgag  ttgacatca  tatgaatga  660
cctcttttt  caaagcaat  gtacctgtt  aacactggg  aagctgacg  gactcctgg  720
ctagacttg  atgtggccg  agcctggga  ctgggatac  cagggaaag  agtgaccat  780
ggaatcatg  acgatggaa  tgactatct  cacccagac  tggcctaca  ctataactc  840
gatgcaagt  atgacttca  cagcaatga  ccctatcca  accctcgat  cacagatga  900
tggttcaac  gccatggaa  caggtgtgc  ggagaagtt  ccgctgcag  cagcaacaa  960
atctgtgga  tcggtgtag  atacaactc  aaggtggca  gtatccgga  gctggacca  1020
ccctttatg  ctgacatca  cgaggcctc  tccatcagc  acatgcctc  actgatcga  1080
atctacagt  caagctggg  ccccacaga  aacgggaag  cagttgatg  gccccgaga  1140
ctcacgctc  aggccatgg  tgatggtgt  aacaagggc  gtgggggca  aggcagcat  1200
tatgtgtgg  cctccgggg  cggtggcag  tacgatgac  gcaactgtg  cggtatcta  1260
gcgtcaagc  tgtggacca  ctccatcaa  tcggccatc  acgacggca  gaccgcctt  1320
catgacgag  gctgctctt  caccttggc  tctacgttc  gcaacggga  gaagaggaa  1380
cccgaggcc  gtgtggcta  cacagactt  tatggcaac  gtactctga  gcattctgg  1440
acatctgca  ctgctcctg  ggcagctgg  gtgtttgca  tggctttgg  ggctaacgt  1500
gatctgacc  ggcgagaca  gcaacatct  acagtgctc  cctccaagc  aaaccagct  1560
cacgatgag  ttcatcagt  gcgacggaa  ggggttggc  tggaattca  tcacctctt  1620
ggctacgga  tccttgatg  aggtgccat  gtgaaaatg  ctaaagact  gaaaactgt  1680
ccagagaga  tccactgtg  gggaggctc  gtgcagaac  ctgagaaaa  accacccac  1740
ggcaagttg  tactgaccc  ccaaacaaa  gcatgtgag  ggaaagaaa  cttcgtccg  1800
tacctcgag  atgtccaag  tgtcatcac  gtcaacgca  ccaggagag  agacctgaa  1860
atcaacatg  cctccccga  gggcaccaa  tccattttg  taagccggc  tccaagaga  1920
gacgactcc  aggtgggct  tgacaagtg  cctttcatg  ccacccaca  ctgggggga  1980
gatgcccga  ggacctgga  cctggagct  gggtttgtg  gcagtgcac  acagaaggg  2040
ttgctgaag  aatggaccc  catgctaca  ggcacccag  gtgccccat  catcgatca  2100
gtggtgagg  attaccaat  gaagttggc  atgtccaag  agcaagagc  ggaggaaga  2160
ctagatgaa  ctgtggaga  aagtctgca  agtatcctg  gaaagaact  gggccacgc  2220
tccgcctcc  tctcccctt  ctccctgtc  ctgcctctc  ttggtccac  gttctggca  2280
ccaccagcc  cccagcaat  cctgttacc  tcacacaag  agtcccagc  tggtctgaa  2340
ctttgcttg  tctcaatga  tattttcac  acaatggaa  caatcattt  tattctgta  2400
cccaaatat  gcgttccta  caacatct  2428



<210> 4008
<211> 637
<212> PRT
<213> Rattus norvegicus
<308> P28841
<400> 4008

Met Glu Gly Gly Cys Gly Ser Gln Trp Lys Ala Ala Gly Leu Leu Phe 
  1               5                  10                  15
Cys Val Met Val Phe Ala Ser Ala Glu Arg Pro Val Phe Thr Asn His 
             20                  25                  30
Phe Leu Val Glu Leu His Lys Asp Gly Glu Glu Glu Ala Arg Gln Val 
         35                  40                  45
Ala Ala Glu His Gly Phe Gly Val Arg Lys Leu Pro Phe Ala Glu Gly 
     50                  55                  60
Leu Tyr His Phe Tyr His Asn Gly Leu Ala Lys Ala Lys Arg Arg Arg 
 65                  70                  75                  80
Ser Leu His His Lys Arg Gln Leu Glu Arg Asp Pro Arg Ile Lys Met 
                 85                  90                  95
Ala Leu Gln Gln Glu Gly Phe Asp Arg Lys Lys Arg Gly Tyr Arg Asp 
             100                105                110
Ile Asn Glu Ile Asp Ile Asn Met Asn Asp Pro Leu Phe Thr Lys Gln 
         115                120                125
Trp Tyr Leu Phe Asn Thr Gly Gln Ala Asp Gly Thr Pro Gly Leu Asp 
     130                135                140
Leu Asn Val Ala Glu Ala Trp Glu Leu Gly Tyr Thr Gly Lys Gly Val 
 145                150                155                160
Thr Ile Gly Ile Met Asp Asp Gly Ile Asp Tyr Leu His Pro Asp Leu 
                 165                170                175
Ala Tyr Asn Tyr Asn Ser Asp Ala Ser Tyr Asp Phe Ser Ser Asn Asp 
             180                185                190
Pro Tyr Pro Tyr Pro Arg Tyr Thr Asp Asp Trp Phe Asn Ser His Gly 
         195                200                205
Thr Arg Cys Ala Gly Glu Val Ser Ala Ala Ala Ser Asn Asn Ile Cys 
     210                215                220
Gly Val Gly Val Ala Tyr Asn Ser Lys Val Ala Gly Ile Arg Met Leu 
 225                230                235                240
Asp Gln Pro Phe Met Thr Asp Ile Ile Glu Ala Ser Ser Ile Ser His 
                 245                250                255
Met Pro Gln Leu Ile Asp Ile Tyr Ser Ala Ser Trp Gly Pro Thr Asp 
             260                265                270
Asn Gly Lys Thr Val Asp Gly Pro Arg Glu Leu Thr Leu Gln Ala Met 
         275                280                285
Ala Asp Gly Val Asn Lys Gly Arg Gly Gly Lys Gly Ser Ile Tyr Val 
     290                295                300
Trp Ala Ser Gly Asp Gly Gly Ser Tyr Asp Asp Cys Asn Cys Asp Gly 
 305                310                315                320
Tyr Ala Ser Ser Met Trp Thr Ile Ser Ile Asn Ser Ala Ile Asn Asp 
                 325                330                335
Gly Arg Thr Ala Leu Tyr Asp Glu Ser Cys Ser Ser Thr Leu Ala Ser 
             340                345                350
Thr Phe Ser Asn Gly Arg Lys Arg Asn Pro Glu Ala Gly Val Ala Thr 
         355                360                365
Thr Asp Leu Tyr Gly Asn Cys Thr Leu Arg His Ser Gly Thr Ser Ala 
     370                375                380
Ala Ala Pro Glu Ala Ala Gly Val Phe Ala Leu Ala Leu Glu Ala Asn 
 385                390                395                400
Val Asp Leu Thr Trp Arg Asp Met Gln His Leu Thr Val Leu Thr Ser 
                 405                410                415
Lys Arg Asn Gln Leu His Asp Glu Val His Gln Trp Arg Arg Asn Gly 
             420                425                430
Val Gly Leu Glu Phe Asn His Leu Phe Gly Tyr Gly Val Leu Asp Ala 
         435                440                445
Gly Ala Met Val Lys Met Ala Lys Asp Trp Lys Thr Val Pro Glu Arg 
     450                455                460
Phe His Cys Val Gly Gly Ser Val Gln Asn Pro Glu Lys Ile Pro Pro 
 465                470                475                480
Thr Gly Lys Leu Val Leu Thr Leu Gln Thr Asn Ala Cys Glu Gly Lys 
                 485                490                495
Glu Asn Phe Val Arg Tyr Leu Glu His Val Gln Ala Val Ile Thr Val 
             500                505                510
Asn Ala Thr Arg Arg Gly Asp Leu Asn Ile Asn Met Thr Ser Pro Met 
         515                520                525
Gly Thr Lys Ser Ile Leu Leu Ser Arg Arg Pro Arg Asp Asp Asp Ser 
     530                535                540
Lys Val Gly Phe Asp Lys Trp Pro Phe Met Thr Thr His Thr Trp Gly 
 545                550                555                560
Glu Asp Ala Arg Gly Thr Trp Thr Leu Glu Leu Gly Phe Val Gly Ser 
                 565                570                575
Ala Pro Gln Lys Gly Leu Leu Lys Glu Trp Thr Leu Met Leu His Gly 
             580                585                590
Thr Gln Ser Ala Pro Tyr Ile Asp Gln Val Val Arg Asp Tyr Gln Ser 
         595                600                605
Lys Leu Ala Met Ser Lys Lys Gln Glu Leu Glu Glu Glu Leu Asp Glu 
     610                615                620
Ala Val Glu Arg Ser Leu Gln Ser Ile Leu Arg Lys Asn 
 625                630                635



<210> 4009
<211> 2411
<212> DNA
<213> Homo sapiens
<308> BC005815
<400> 4009

ggcacgagg  cggtacaca  agctcccca  attctcacc  ctgcccgcg  gccgggccg  60
ctgactgca  ggcttcccc  ccagccaga  gctggagaa  acacactga  tcgctgctt  120
ccaagaccc  gttcagtct  tttctctat  caaagattt  tttaaaaac  atatataag  180
attctttat  tgcaccctc  ctccgagtc  cctgctccg  cagcctgcg  gcctcctag  240
accactttt  actcccaaa  aaggatgaa  ggtggttgt  tctcccagt  gaaggcggc  300
gccgggttc  tcttctgtg  catggtttt  gcatctgct  agcgaccgg  cttcacgaa  360
cattttctt  tggagttgc  taaaggggg  gaggacaaa  ctcgccaag  tgcagcaga  420
cacggcttt  gagtccgaa  gcttccctt  gctgaaggt  tgtaccact  ttatcacaa  480
ggccttgca  aggccaaga  aagacgcag  ctacaccac  agcagcagc  ggagagaga  540
cccagggta  agatggctt  gcagcagga  ggatttgac  gaaaaaagc  aggttacag  600
gacatcaat  agatcgaca  caacatgaa  gatcctctt  ttacaaagc  gtggtatct  660
atcaatact  ggcaagctg  tggcactcc  ggccttgat  tgaatgtgg  tgaagcctg  720
gagctggga  acacaggga  aggtgttac  attggaatt  tggatgatg  gattgacta  780
ctccacccg  acctggcct  caactataa  gccgaagca  gttacgact  cagcagcaa  840
gacccctat  cttaccctc  gtacacaga  gactggttt  acagccacg  gacccgatg  900
gcaggagaa  tttctgctg  cgccaacaa  aatatctgt  gagttggag  agcatacaa  960
tccaaggtt  caggcatcc  gatgctgga  cagccattc  tgacagaca  catcgaggc  1020
tcctccatc  gtcatatgc  acagctgat  gacatctac  gcgccagct  gggccccac  1080
gacaacggc  agacagtgg  tgggccccg  gagctcacg  tgcaggcca  ggccgatgg  1140
gtgaacaag  gccgcggcg  caaaggcag  atctacgtg  gggcctccg  ggacggcgg  1200
agctatgac  actgcaact  cgacggcta  gcctccagc  tgtggacca  ctccatcaa  1260
tcagccatc  acgacggca  gactgccct  tacgacgag  gctgctctt  caccttggc  1320
tccaccttc  gcaacggga  gaaaaggaa  cccgaggcc  gtgtggcaa  cacagattt  1380
tacggcaac  gcactctga  gcattctgg  acatctgca  ctgcccccg  ggcagctgg  1440
gtgtttgca  tggctctgg  ggctaacct  ggtctgacc  ggcgggaca  gcagcatct  1500
actgtgctc  cctccaaac  gaaccagct  cacgacgag  tccatcagt  gcggcgcaa  1560
ggggtcggc  tggaattta  tcacctctt  ggctacggg  tccttgatg  aggtgccat  1620
gtgaaaatg  ctaaagact  gaaaaccgt  cctgagaga  tccactgtg  gggaggctc  1680
gtgcaggac  ctgagaaaa  accatccac  ggcaagttg  tgctgacac  cacaaccga  1740
gcctgtgag  ggaaggaaa  ttttgtccg  tacctggag  atgtccagg  tgtcatcac  1800
gtcaacgca  ccagaagag  agacctgaa  atcaacatg  cttccccta  gggcaccaa  1860
tccattttg  tgagccggc  tccaaggga  gacgactcc  aggtgggct  tgacaagtg  1920
cctttcatg  ccactcaca  gtgggggga  gacgcccga  gcacctgga  cctggagct  1980
ggatttgtc  gcagcgccc  gcagaaggg  gtgctgaag  agtggaccc  gatgctgca  2040
ggcactcag  gtgccccgt  catcgacca  gtggtgcgg  attaccagt  caagttggc  2100
atgtccaag  aagaggagc  ggaggaaga  ctggacgaa  ccgtggaga  aagcctgaa  2160
agcatcctt  acaagaact  gcgctgcac  tccgccttt  ccaccgccc  ccctcccca  2220
ctccgcctc  gtcctcgct  cacgtttca  gcaggcacc  agcaattcc  tcacccgta  2280
aggcaattc  gtcttctta  tctgaagct  cactcactg  caatgatta  tttcattac  2340
atggaaaca  tctttttta  tctatgccc  aaatatagc  ttcccaaca  caaaaaaaa  2400
aaaaaaaaa  a  2411



<210> 4010
<211> 638
<212> PRT
<213> Homo sapiens
<308> P16519
<400> 4010

Met Lys Gly Gly Cys Val Ser Gln Trp Lys Ala Ala Ala Gly Phe Leu 
  1               5                  10                  15
Phe Cys Val Met Val Phe Ala Ser Ala Glu Arg Pro Val Phe Thr Asn 
             20                  25                  30
His Phe Leu Val Glu Leu His Lys Gly Gly Glu Asp Lys Ala Arg Gln 
         35                  40                  45
Val Ala Ala Glu His Gly Phe Gly Val Arg Lys Leu Pro Phe Ala Glu 
     50                  55                  60
Gly Leu Tyr His Phe Tyr His Asn Gly Leu Ala Lys Ala Lys Arg Arg 
 65                  70                  75                  80
Arg Ser Leu His His Lys Gln Gln Leu Glu Arg Asp Pro Arg Val Lys 
                 85                  90                  95
Met Ala Leu Gln Gln Glu Gly Phe Asp Arg Lys Lys Arg Gly Tyr Arg 
             100                105                110
Asp Ile Asn Glu Ile Asp Ile Asn Met Asn Asp Pro Leu Phe Thr Lys 
         115                120                125
Gln Trp Tyr Leu Ile Asn Thr Gly Gln Ala Asp Gly Thr Pro Gly Leu 
     130                135                140
Asp Leu Asn Val Ala Glu Ala Trp Glu Leu Gly Tyr Thr Gly Lys Gly 
 145                150                155                160
Val Thr Ile Gly Ile Met Asp Asp Gly Ile Asp Tyr Leu His Pro Asp 
                 165                170                175
Leu Ala Ser Asn Tyr Asn Ala Glu Ala Ser Tyr Asp Phe Ser Ser Asn 
             180                185                190
Asp Pro Tyr Pro Tyr Pro Arg Tyr Thr Asp Asp Trp Phe Asn Ser His 
         195                200                205
Gly Thr Arg Cys Ala Gly Glu Val Ser Ala Ala Ala Asn Asn Asn Ile 
     210                215                220
Cys Gly Val Gly Val Ala Tyr Asn Ser Lys Val Ala Gly Ile Arg Met 
 225                230                235                240
Leu Asp Gln Pro Phe Met Thr Asp Ile Ile Glu Ala Ser Ser Ile Ser 
                 245                250                255
His Met Pro Gln Leu Ile Asp Ile Tyr Ser Ala Ser Trp Gly Pro Thr 
             260                265                270
Asp Asn Gly Lys Thr Val Asp Gly Pro Arg Glu Leu Thr Leu Gln Ala 
         275                280                285
Met Ala Asp Gly Val Asn Lys Gly Arg Gly Gly Lys Gly Ser Ile Tyr 
     290                295                300
Val Trp Ala Ser Gly Asp Gly Gly Ser Tyr Asp Asp Cys Asn Cys Asp 
 305                310                315                320
Gly Tyr Ala Ser Ser Met Trp Thr Ile Ser Ile Asn Ser Ala Ile Asn 
                 325                330                335
Asp Gly Arg Thr Ala Leu Tyr Asp Glu Ser Cys Ser Ser Thr Leu Ala 
             340                345                350
Ser Thr Phe Ser Asn Gly Arg Lys Arg Asn Pro Glu Ala Gly Val Ala 
         355                360                365
Thr Thr Asp Leu Tyr Gly Asn Cys Thr Leu Arg His Ser Gly Thr Ser 
     370                375                380
Ala Ala Ala Pro Glu Ala Ala Gly Val Phe Ala Leu Ala Leu Glu Ala 
 385                390                395                400
Asn Leu Gly Leu Thr Trp Arg Asp Met Gln His Leu Thr Val Leu Thr 
                 405                410                415
Ser Lys Arg Asn Gln Leu His Asp Glu Val His Gln Trp Arg Arg Asn 
             420                425                430
Gly Val Gly Leu Glu Phe Asn His Leu Phe Gly Tyr Gly Val Leu Asp 
         435                440                445
Ala Gly Ala Met Val Lys Met Ala Lys Asp Trp Lys Thr Val Pro Glu 
     450                455                460
Arg Phe His Cys Val Gly Gly Ser Val Gln Asp Pro Glu Lys Ile Pro 
 465                470                475                480
Ser Thr Gly Lys Leu Val Leu Thr Leu Thr Thr Asp Ala Cys Glu Gly 
                 485                490                495
Lys Glu Asn Phe Val Arg Tyr Leu Glu His Val Gln Ala Val Ile Thr 
             500                505                510
Val Asn Ala Thr Arg Arg Gly Asp Leu Asn Ile Asn Met Thr Ser Pro 
         515                520                525
Met Gly Thr Lys Ser Ile Leu Leu Ser Arg Arg Pro Arg Asp Asp Asp 
     530                535                540
Ser Lys Val Gly Phe Asp Lys Trp Pro Phe Met Thr Thr His Thr Trp 
 545                550                555                560
Gly Glu Asp Ala Arg Gly Thr Trp Thr Leu Glu Leu Gly Phe Val Gly 
                 565                570                575
Ser Ala Pro Gln Lys Gly Val Leu Lys Glu Trp Thr Leu Met Leu His 
             580                585                590
Gly Thr Gln Ser Ala Pro Tyr Ile Asp Gln Val Val Arg Asp Tyr Gln 
         595                600                605
Ser Lys Leu Ala Met Ser Lys Lys Glu Glu Leu Glu Glu Glu Leu Asp 
     610                615                620
Glu Ala Val Glu Arg Ser Leu Lys Ser Ile Leu Asn Lys Asn 
 625                630                635



<210> 4011
<211> 2042
<212> DNA
<213> Rattus norvegicus
<308> M84719
<400> 4011

gaacataaa  tcagattgc  aaacttctg  gtcgactga  aaacatggt  aagcgagtt  60
caattgtgg  agctggggt  agtggcctg  cctccatca  gtgctgcct  gaagaagga  120
tagaaccca  ctgcttcga  agaagctgt  acttgggag  actttggag  ttcacggaa  180
atgttgaag  aggaagagc  agcctttac  actcagtgg  ttctaacag  agcaaggag  240
tgtcttgtt  ctccgattt  ccttttcca  aagactacc  aaactttgt  ccaaattct  300
tgttcctgg  atatctcca  ctgtatgca  cccagttca  ccttctgag  tgcatctat  360
tcaacacca  agtgtgcag  ataacaaaa  gcccagatt  cgctgtctc  ggacaatgg  420
aagtggtca  tgtctgtca  gggaagcaa  gctcagaca  ctttgctgc  gtcatggtc  480
gcactgggt  tctaactaa  ccacatctg  ccctggatt  ctttccagg  atacaaact  540
ttaaggggc  gtacttcca  agccggcag  ataaacatc  agacgtatt  aaggacaag  600
gagtccttg  ggttggaat  ggaaattct  gtacagaca  tgccgtgga  gccagtcac  660
tagcgaaaa  ggtgtttct  agcaccacc  gaggggcat  ggtgatcag  cgagtcttt  720
attcagggt  cccctggga  atgatattc  tgacgcgat  tcagaacat  ctcagaaat  780
ttctcccaa  tccagttgt  agttggttg  tatcaaaga  gatgaacag  tggttcaac  840
acgtgaatt  cggtgtggc  ccagaagac  ggactcagc  gagagagcc  gtgctgaat  900
atgagctcc  aggccgcat  atcactggg  aagtgttga  caagcccag  atcaaggag  960
tgaaagaaa  ctctgtcgt  tttaacaat  caccgaagg  ggagcctat  gacgtcatc  1020
tctttgcca  tggatactc  tttgcgttc  ccttcctcg  tgaatcaat  gtgaaagtt  1080
aggatggcc  ggcatcact  tacaagtac  tcttcccgg  acatctgcc  aaaccaact  1140
tggccgtga  tggcctcat  aaacccctg  gttccatga  acccacagg  gagacacaa  1200
ctcgatggg  tgttcaggt  ctgaaaggt  cgactacat  accaccccc  agtgtcatg  1260
tgaaagaag  caatgaacg  aagaagaac  agcatagcg  atttggctt  tgctactgc  1320
aggctttgc  atccgatta  ataacgtac  tagatgacc  cctgacctc  atcaacgca  1380
aaccggacc  gcgggccat  ctcctgact  acccacgcc  ggctctgag  atcttcttc  1440
gcccatgca  accttacca  ttccgcctg  ctggtccag  aaagtggga  ggagccaga  1500
aggccatct  gacccagtg  gaccgaaca  tgaacgtca  caaaactcg  accgtacaa  1560
aaaccccat  tacctttga  actttgctt  aactcttta  ttttctggc  ttgcttgtg  1620
ctgttttct  tattttcct  taagtgaaa  atctaactg  ctttccaaa  gtgtggagt  1680
taaccttcc  acttctcta  tgtaacaat  tcaccttcg  aattgtaaa  cacgtccag  1740
gacacccaa  ccctacctc  ccccaactc  cctcattgg  accttcatt  ctgggtctc  1800
tgctagtcc  tcaggttta  tgcaagaaa  taatgtcca  caattctgt  cacttaaaa  1860
gttggaagg  tccaggccc  ctttcagga  gaatctgcc  ccagagagg  ctctgagca  1920
tctttcaat  taaaaaact  ctttcccta  atcttaatg  aaagcccaa  ttcgcggaa  1980
attggtctg  actaaaata  ttctctgtg  attagttga  tacaaataa  atggaagaa  2040
ct  2042



<210> 4012
<211> 532
<212> PRT
<213> Rattus norvegicus
<308> P36365
<400> 4012

Met Val Lys Arg Val Ala Ile Val Gly Ala Gly Val Ser Gly Leu Ala 
  1               5                  10                  15
Ser Ile Lys Cys Cys Leu Glu Glu Gly Leu Glu Pro Thr Cys Phe Glu 
             20                  25                  30
Arg Ser Cys Asp Leu Gly Gly Leu Trp Arg Phe Thr Glu His Val Glu 
         35                  40                  45
Glu Gly Arg Ala Ser Leu Tyr Asn Ser Val Val Ser Asn Ser Ser Lys 
     50                  55                  60
Glu Met Ser Cys Tyr Ser Asp Phe Pro Phe Pro Glu Asp Tyr Pro Asn 
 65                  70                  75                  80
Phe Val Pro Asn Ser Leu Phe Leu Glu Tyr Leu Gln Leu Tyr Ala Thr 
                 85                  90                  95
Gln Phe Asn Leu Leu Arg Cys Ile Tyr Phe Asn Thr Lys Val Cys Ser 
             100                105                110
Ile Thr Lys Arg Pro Asp Phe Ala Val Ser Gly Gln Trp Glu Val Val 
         115                120                125
Thr Val Cys Gln Gly Lys Gln Ser Ser Asp Thr Phe Ala Ala Val Met 
     130                135                140
Val Cys Thr Gly Phe Leu Thr Asn Pro His Leu Pro Leu Asp Ser Phe 
 145                150                155                160
Pro Gly Ile Gln Thr Phe Lys Gly Gln Tyr Phe His Ser Arg Gln Tyr 
                 165                170                175
Lys His Pro Asp Val Phe Lys Asp Lys Arg Val Leu Val Val Gly Met 
             180                185                190
Gly Asn Ser Gly Thr Asp Ile Ala Val Glu Ala Ser His Leu Ala Lys 
         195                200                205
Lys Val Phe Leu Ser Thr Thr Gly Gly Ala Trp Val Ile Ser Arg Val 
     210                215                220
Phe Asp Ser Gly Tyr Pro Trp Asp Met Ile Phe Met Thr Arg Phe Gln 
 225                230                235                240
Asn Met Leu Arg Asn Leu Leu Pro Thr Pro Val Val Ser Trp Leu Ile 
                 245                250                255
Ser Lys Lys Met Asn Ser Trp Phe Asn His Val Asn Tyr Gly Val Ala 
             260                265                270
Pro Glu Asp Arg Thr Gln Leu Arg Glu Pro Val Leu Asn Asp Glu Leu 
         275                280                285
Pro Gly Arg Ile Ile Thr Gly Lys Val Leu Ile Lys Pro Ser Ile Lys 
     290                295                300
Glu Val Lys Glu Asn Ser Val Val Phe Asn Asn Thr Pro Lys Glu Glu 
 305                310                315                320
Pro Ile Asp Val Ile Val Phe Ala Thr Gly Tyr Ser Phe Ala Phe Pro 
                 325                330                335
Phe Leu Asp Glu Ser Ile Val Lys Val Glu Asp Gly Gln Ala Ser Leu 
             340                345                350
Tyr Lys Tyr Ile Phe Pro Ala His Leu Pro Lys Pro Thr Leu Ala Val 
         355                360                365
Ile Gly Leu Ile Lys Pro Leu Gly Ser Met Ile Pro Thr Gly Glu Thr 
     370                375                380
Gln Ala Arg Trp Val Val Gln Val Leu Lys Gly Ala Thr Thr Leu Pro 
 385                390                395                400
Pro Pro Ser Val Met Met Lys Glu Val Asn Glu Arg Lys Lys Asn Lys 
                 405                410                415
His Ser Gly Phe Gly Leu Cys Tyr Cys Lys Ala Leu Gln Ser Asp Tyr 
             420                425                430
Ile Thr Tyr Ile Asp Asp Leu Leu Thr Ser Ile Asn Ala Lys Pro Asp 
         435                440                445
Leu Arg Ala Met Leu Leu Thr Asp Pro Arg Leu Ala Leu Ser Ile Phe 
     450                455                460
Phe Gly Pro Cys Thr Pro Tyr His Phe Arg Leu Thr Gly Pro Gly Lys 
 465                470                475                480
Trp Glu Gly Ala Arg Lys Ala Ile Leu Thr Gln Trp Asp Arg Thr Val 
                 485                490                495
Asn Val Thr Lys Thr Arg Thr Val Gln Glu Thr Pro Ser Thr Phe Glu 
             500                505                510
Thr Leu Leu Lys Leu Phe Ser Phe Leu Ala Leu Leu Val Ala Val Phe 
         515                520                525
Phe Ile Phe Leu 
     530



<210> 4013
<211> 2134
<212> DNA
<213> Homo sapiens
<308> M64082
<400> 4013

acccaagcc  gcactggct  atactgatt  attttgatc  ctgctaata  cagagtcct  60
cgtggcaga  ccattggca  cagaaatta  aagagaaca  ggccaagcg  gttgccatt  120
tgggagctg  ggtcagcgg  ctggcctcc  tcaagtgct  tctggaaga  ggactggag  180
ccacctgct  tgagaggag  gatgacctt  gggggctgt  gagattcac  gaacatgtt  240
aagaaggca  agccagtct  tacaagtct  tggtttcca  cagctgcaa  gagatgtct  300
gttactcag  ctttccatt  ccagaagat  atccaaact  tgtgccaaa  tctcaattc  360
tggaatatc  caaaatgta  gcaaaccac  ttgaccttc  gaaacacat  caattcaag  420
ccaaagtct  cagtgtaac  aaatgctca  attctgctg  ctctggcca  tgggaggtg  480
tcactatgc  tgaagagaa  caagagtca  ccatctttg  tgctgtcat  gtctgcact  540
gctttctta  taatcctta  ttgccactg  attcctttc  aggtattaa  gcctttaaa  600
gccagtact  tcatagccg  caatataag  atccagata  atttaagga  aagagagtc  660
ttgtgattg  aatgggaaa  tctggcaca  acattgctg  ggaggccag  cacctggcg  720
aaaaggtgt  cctcagcac  accggaggg  gatgggtga  cagccgaat  tttgactcg  780
gctacccat  ggacatggt  ttcatgaca  gctttcaga  catgttgag  aattccctc  840
caaccccaa  tgtgacttg  ttgatggag  gaaagataa  caactggct  aatcatgca  900
attacggct  aataccaga  gacaggact  agctgaaag  gtttgtgct  aatgatgag  960
tcccaggac  catcatcac  gggaaagtg  tcatcaggc  aagcataaa  gaggtaaag  1020
aaaactctg  catatttaa  aatacttca  aggaagagc  tattgacat  attgtcttt  1080
ccactggat  cacatttgc  ttccccttc  ttgatgagt  tgtagtgaa  gttgaagat  1140
gccaggcct  actgtacaa  tatatcttc  ctgcacatc  gcaaaagcc  accctggcc  1200
ttattggcc  catcaaacc  ttgggctcc  tgataccta  aggagaaac  caagctcgg  1260
gggctgttc  agtcctgaa  ggtgtaaat  agttaccac  accaagtgt  atgatagag  1320
aaattaatg  aaggaaaga  aacaagccc  gttggtttg  cttgtgcta  tgcaaggct  1380
tacaatcag  ttatatcac  tacatagat  aactcctga  ctatatcaa  gcaaaaccc  1440
acctgttct  tatgctcct  acggatcca  atctggctc  gaccgtctt  tttggccca  1500
gctcaccat  ccagttccg  ttgactggc  caggaaaat  ggaaggagc  agaaatgcc  1560
tcatgaccc  gtgggaccg  acattcaag  tcatcaaag  tcgagttgt  caagagtct  1620
catctccct  tgaaagttt  cttaaagtc  ttagctttc  ggctttgct  gtggctatt  1680
ttctgattt  cctataagt  aaagatctc  taaatggaa  atgcacaga  tagatttac  1740
atgctccaa  tcctctctt  cagcaatat  gccttcaca  ttataaact  tattcaaat  1800
gtaaaggcc  ccctctcgc  tccctggct  gccccaggg  taccactgg  attcctgag  1860
ctctcccag  tccacttct  atgctagag  atgataact  agacttctg  gcatttgaa  1920
gttgttgga  agttacagg  tcattttag  aagaaagct  ttcttgaca  cactctgag  1980
catcatacc  ctttcccat  taaactatt  tcacagatc  caactaaaa  cccttactt  2040
acaaatgat  gtgttgtgc  gaaatggtg  tcttatagt  ctggcttat  aaaagtaaa  2100
aataaacct  aaaattgat  gttttaaaa  aaaa  2134



<210> 4014
<211> 531
<212> PRT
<213> Homo sapiens
<308> Q01740
<400> 4014

Ala Lys Arg Val Ala Ile Val Gly Ala Gly Val Ser Gly Leu Ala Ser 
  1               5                  10                  15
Ile Lys Cys Cys Leu Glu Glu Gly Leu Glu Pro Thr Cys Phe Glu Arg 
             20                  25                  30
Ser Asp Asp Leu Gly Gly Leu Trp Arg Phe Thr Glu His Val Glu Glu 
         35                  40                  45
Gly Arg Ala Ser Leu Tyr Lys Ser Val Val Ser Asn Ser Cys Lys Glu 
     50                  55                  60
Met Ser Cys Tyr Ser Asp Phe Pro Phe Pro Glu Asp Tyr Pro Asn Tyr 
 65                  70                  75                  80
Val Pro Asn Ser Gln Phe Leu Glu Tyr Leu Lys Met Tyr Ala Asn His 
                 85                  90                  95
Phe Asp Leu Leu Lys His Ile Gln Phe Lys Thr Lys Val Cys Ser Val 
             100                105                110
Thr Lys Cys Ser Asp Ser Ala Val Ser Gly Gln Trp Glu Val Val Thr 
         115                120                125
Met His Glu Glu Lys Gln Glu Ser Ala Ile Phe Asp Ala Val Met Val 
     130                135                140
Cys Thr Gly Phe Leu Thr Asn Pro Tyr Leu Pro Leu Asp Ser Phe Pro 
 145                150                155                160
Gly Ile Asn Ala Phe Lys Gly Gln Tyr Phe His Ser Arg Gln Tyr Lys 
                 165                170                175
His Pro Asp Ile Phe Lys Asp Lys Arg Val Leu Val Ile Gly Met Gly 
             180                185                190
Asn Ser Gly Thr Asp Ile Ala Val Glu Ala Ser His Leu Ala Glu Lys 
         195                200                205
Val Phe Leu Ser Thr Thr Gly Gly Gly Trp Val Ile Ser Arg Ile Phe 
     210                215                220
Asp Ser Gly Tyr Pro Trp Asp Met Val Phe Met Thr Arg Phe Gln Asn 
 225                230                235                240
Met Leu Arg Asn Ser Leu Pro Thr Pro Ile Val Thr Trp Leu Met Glu 
                 245                250                255
Arg Lys Ile Asn Asn Trp Leu Asn His Ala Asn Tyr Gly Leu Ile Pro 
             260                265                270
Glu Asp Arg Thr Gln Leu Lys Glu Phe Val Leu Asn Asp Glu Leu Pro 
         275                280                285
Gly Arg Ile Ile Thr Gly Lys Val Phe Ile Arg Pro Ser Ile Lys Glu 
     290                295                300
Val Lys Glu Asn Ser Val Ile Phe Asn Asn Thr Ser Lys Glu Glu Pro 
 305                310                315                320
Ile Asp Ile Ile Val Phe Ala Thr Gly Tyr Thr Phe Ala Phe Pro Phe 
                 325                330                335
Leu Asp Glu Ser Val Val Lys Val Glu Asp Gly Gln Ala Ser Leu Tyr 
             340                345                350
Lys Tyr Ile Phe Pro Ala His Leu Gln Lys Pro Thr Leu Ala Ile Ile 
         355                360                365
Gly Leu Ile Lys Pro Leu Gly Ser Met Ile Pro Thr Gly Glu Thr Gln 
     370                375                380
Ala Arg Trp Ala Val Arg Val Leu Lys Gly Val Asn Lys Leu Pro Pro 
 385                390                395                400
Pro Ser Val Met Ile Glu Glu Ile Asn Ala Arg Lys Glu Asn Lys Pro 
                 405                410                415
Ser Trp Phe Gly Leu Cys Tyr Cys Lys Ala Leu Gln Ser Asp Tyr Ile 
             420                425                430
Thr Tyr Ile Asp Glu Leu Leu Thr Tyr Ile Asn Ala Lys Pro Asn Leu 
         435                440                445
Phe Ser Met Leu Leu Thr Asp Pro His Leu Ala Leu Thr Val Phe Phe 
     450                455                460
Gly Pro Cys Ser Pro Tyr Gln Phe Arg Leu Thr Gly Pro Gly Lys Trp 
 465                470                475                480
Glu Gly Ala Arg Asn Ala Ile Met Thr Gln Trp Asp Arg Thr Phe Lys 
                 485                490                495
Val Ile Lys Ala Arg Val Val Gln Glu Ser Pro Ser Pro Phe Glu Ser 
             500                505                510
Phe Leu Lys Val Phe Ser Phe Leu Ala Leu Leu Val Ala Ile Phe Leu 
         515                520                525
Ile Phe Leu 
     530



<210> 4015
<211> 1342
<212> DNA
<213> Rattus norvegicus
<308> M86235
<400> 4015

gcagccaga  gccaggctg  atgaaatga  gaaggcaat  gcaggcagt  gtgccagcc  60
ctgaggtgt  gagctgcta  ctcccaccg  tcatctctc  cacaatgcc  tcaaacccc  120
gcaagccac  cttcttgcc  gccacctgg  acccgaatc  cagggcctc  tgcatgctg  180
ttcccttgg  gaggctgaa  agacagagt  tagcaggaa  cccctccgc  tgcgggtag  240
aagcttggg  agcagcctc  tggaagaga  gcagatcct  tgcgtgggg  tggtggtgc  300
ggacatcat  aatgtggtg  acaaatacc  agaggaaga  acggatcgc  ggtgcctat  360
ccagagatg  cagcgtgga  gcaacgcgt  caactcctg  actgtgctt  ccttgctcg  420
agcccgctg  gccttcatg  gctcgctgg  ccatggcca  gttgccgac  tcctggtgg  480
cgacttcag  cggaggggt  tggatgtgt  tcaagtggc  tggcagagc  agggagata  540
cccttgctc  tgctgcatc  tcaacaact  caatggctc  cgtaccatt  ttctctacg  600
cacgaacct  ccagatgtg  ctgctaagg  ctttgagaa  gtcgatctg  cccggttca  660
gtggatcca  attgagggc  ggaatgcat  ggaacaggt  aagatgcta  agcggatag  720
acagtacaa  gccacgcag  ctctgcagc  gaaggtccg  gtgtccgtg  agatagaga  780
gccccgaga  gaactcttc  agctgttcg  ctatggaga  gtggtgttt  tcagcaaag  840
tgtggccaa  cacctgggg  tccggtcag  aggggaggc  ctgaagggc  tgtacagtc  900
tgtgaagaa  ggggctacg  tcatctgtg  ctgggctga  gagggagcc  atgccctgg  960
ccccgacgg  cagctgctc  actcagatg  cttcccacc  ccccgagta  tagacactc  1020
cggggctgg  gacaccttc  atgcctctg  catcttcag  ctctccaag  gaaacagca  1080
gcaggaggc  ctgagattc  ggtgccagg  ggctggcaa  aagtgtggc  tgcaggggt  1140
tgatggcat  gtgtgagag  tgagcggtg  gaggtagca  ctcgacacc  cagaggctg  1200
caccactgc  tgccattgc  ttcttcatt  catccagcc  ggcgtctgg  tgcccagtt  1260
cctgggcca  tgtaggctg  ggaacgggt  tttctgtct  ttctctgca  acacctgga  1320
caaataaat  ttcccctga  cc  1342



<210> 4016
<211> 298
<212> PRT
<213> Rattus norvegicus
<308> S32426
<400> 4016

Met Glu Glu Lys Gln Ile Leu Cys Val Gly Leu Val Val Leu Asp Ile 
  1               5                  10                  15
Ile Asn Val Val Asp Lys Tyr Pro Glu Glu Asp Thr Asp Arg Arg Cys 
             20                  25                  30
Leu Ser Gln Arg Trp Gln Arg Gly Gly Asn Ala Ser Asn Ser Cys Thr 
         35                  40                  45
Val Leu Ser Leu Leu Gly Ala Arg Cys Ala Phe Met Gly Ser Leu Ala 
     50                  55                  60
His Gly His Val Ala Asp Phe Leu Val Ala Asp Phe Arg Arg Arg Gly 
 65                  70                  75                  80
Val Asp Val Ser Gln Val Ala Trp Gln Ser Gln Gly Asp Thr Pro Cys 
                 85                  90                  95
Ser Cys Cys Ile Val Asn Asn Ser Asn Gly Ser Arg Thr Ile Ile Leu 
             100                105                110
Tyr Asp Thr Asn Leu Pro Asp Val Ser Ala Lys Asp Phe Glu Lys Val 
         115                120                125
Asp Leu Thr Arg Phe Lys Trp Ile His Ile Glu Gly Arg Asn Ala Ser 
     130                135                140
Glu Gln Val Lys Met Leu Gln Arg Ile Glu Gln Tyr Asn Ala Thr Gln 
 145                150                155                160
Pro Leu Gln Gln Lys Val Arg Val Ser Val Glu Ile Glu Lys Pro Arg 
                 165                170                175
Glu Glu Leu Phe Gln Leu Phe Gly Tyr Gly Glu Val Val Phe Val Ser 
             180                185                190
Lys Asp Val Ala Lys His Leu Gly Phe Arg Ser Ala Gly Glu Ala Leu 
         195                200                205
Lys Gly Leu Tyr Ser Arg Val Lys Lys Gly Ala Thr Leu Ile Cys Ala 
     210                215                220
Trp Ala Glu Glu Gly Ala Asp Ala Leu Gly Pro Asp Gly Gln Leu Leu 
 225                230                235                240
His Ser Asp Ala Phe Pro Pro Pro Arg Val Val Asp Thr Leu Gly Ala 
                 245                250                255
Gly Asp Thr Phe Asn Ala Ser Val Ile Phe Ser Leu Ser Lys Gly Asn 
             260                265                270
Ser Met Gln Glu Ala Leu Arg Phe Gly Cys Gln Val Ala Gly Lys Lys 
         275                280                285
Cys Gly Leu Gln Gly Phe Asp Gly Ile Val 
     290                295



<210> 4017
<211> 1899
<212> DNA
<213> Homo sapiens
<308> X78678
<400> 4017

gtagcctca  ggaagagaa  cagatcctg  gcgtggggc  agtggtgct  gacgtcatc  60
gcctggtgg  caagtaccc  aaggaggac  cggagataa  gtgtttgtc  cagagatgg  120
agcgcggag  caacgcgtc  aactcctgc  ccgttctct  cctgctcgg  gccccctgt  180
ccttcatgg  ctcaatggc  cctggccat  ttgctgatt  tgtcctgga  gacctccgc  240
gctattctg  ggacctacg  tacacagtc  ttcagacca  aggctccgt  cccatcgcc  300
cggtcatca  caacgaggc  agtggtagc  gcaccatcc  atactatga  aggagcctg  360
cagatgtgt  tgctacaga  tttgagaag  ttgatctga  ccagttcaa  tggatccac  420
ttgagggcc  gaacgcatc  gagcaggtg  agatgctgc  gcggataga  gcacacaac  480
ccaggcagc  tccagagca  aagatccgg  tgtccgtgg  ggtggagaa  ccacgagag  540
agctcttcc  gctgtttgg  tacggagac  tggtgtttg  cagcaaaga  gtggccaag  600
acttggggt  ccagtcagc  gaggaagcc  tgaggggct  gtatggtcg  gtgaggaaa  660
gggctgtgc  tgtctgtgc  tgggctgag  agggcgccg  cgccctggg  cctgatggc  720
aattgctcc  ctcggatgc  ttcccgcca  cccgcgtgg  ggatacact  ggagctgga  780
acaccttca  tgcctccgt  atcttcagc  tctcccagg  gaggagcgt  caggaagca  840
tgagattcg  gtgccaggt  gccggcaag  agtgtggcc  gcagggctt  gatggcatc  900
tgtgagagc  ggtgccggc  cctcacaca  catggagac  accattgcg  ctgcatcgc  960
ttctcccct  catccagcc  ggcgtccag  ttgccctgt  caggggaca  atgcaagct  1020
tggggagga  tctgcctgt  tcctgtgtt  cccacaggg  gaggctctg  ggggatggc  1080
gggggatgc  gagcctcag  gcaaataaa  cttcctcag  gccagcttc  cctctcaat  1140
tctgaactg  tctggctgg  cattcctga  gctctgact  ttcgatcct  cctctttgt  1200
tccattccc  aaattaacc  ctccgccca  gcccagagg  ggggctgcc  gggctagag  1260
agcgagaag  gccctgggc  tgccaccag  tctgccctg  ctggggagg  cactcggtg  1320
cccacaccc  gtgaacctg  caaagaaac  gtgagagct  ttcggggcc  tgcgttgtg  1380
agactctat  cccacagct  agaagctgg  agtccacac  gctgagctg  actgacagg  1440
cagtggggg  caggggtgc  cctcctctg  cctgcccac  agcctgtga  ttgatgggg  1500
cttcattgt  cagaaatac  tcctcccgc  gactgcccc  gagcctgaa  gtctcaccc  1560
tggagccca  cttggaatt  agggcgtgc  tcagccaca  atgtgaccc  ggatacaga  1620
tgttgctgt  ctcagggag  tccgatctg  aacacatat  ggaattggg  ccaactcca  1680
tatagggtg  gtaaggcct  ataatgtaa  gagcatata  tgtaaaggg  tttagagtg  1740
gacagacct  gattcaaat  tgccattta  ttagctgca  atcacctta  ggtacagca  1800
ttaacgcaa  ctgcctcaa  ttcttcatc  gtcaaatgg  accaattct  cttggctac  1860
gaattattg  gaggataaa  atcatatat  aaaaaaaaa  1899



<210> 4018
<211> 298
<212> PRT
<213> Homo sapiens
<308> P50053
<400> 4018

Met Glu Glu Lys Gln Ile Leu Cys Val Gly Leu Val Val Leu Asp Val 
  1               5                  10                  15
Ile Ser Leu Val Asp Lys Tyr Pro Lys Glu Asp Ser Glu Ile Arg Cys 
             20                  25                  30
Leu Ser Gln Arg Trp Gln Arg Gly Gly Asn Ala Ser Asn Ser Cys Thr 
         35                  40                  45
Val Leu Ser Leu Leu Gly Ala Pro Cys Ala Phe Met Gly Ser Met Ala 
     50                  55                  60
Pro Gly His Val Ala Asp Phe Val Leu Asp Asp Leu Arg Arg Tyr Ser 
 65                  70                  75                  80
Val Asp Leu Arg Tyr Thr Val Phe Gln Thr Thr Gly Ser Val Pro Ile 
                 85                  90                  95
Ala Thr Val Ile Ile Asn Glu Ala Ser Gly Ser Arg Thr Ile Leu Tyr 
             100                105                110
Tyr Asp Arg Ser Leu Pro Asp Val Ser Ala Thr Asp Phe Glu Lys Val 
         115                120                125
Asp Leu Thr Gln Phe Lys Trp Ile His Ile Glu Gly Arg Asn Ala Ser 
     130                135                140
Glu Gln Val Lys Met Leu Gln Arg Ile Asp Ala His Asn Thr Arg Gln 
 145                150                155                160
Pro Pro Glu Gln Lys Ile Arg Val Ser Val Glu Val Glu Lys Pro Arg 
                 165                170                175
Glu Glu Leu Phe Gln Leu Phe Gly Tyr Gly Asp Val Val Phe Val Ser 
             180                185                190
Lys Asp Val Ala Lys His Leu Gly Phe Gln Ser Ala Glu Glu Ala Leu 
         195                200                205
Arg Gly Leu Tyr Gly Arg Val Arg Lys Gly Ala Val Leu Val Cys Ala 
     210                215                220
Trp Ala Glu Glu Gly Ala Asp Ala Leu Gly Pro Asp Gly Lys Leu Leu 
 225                230                235                240
His Ser Asp Ala Phe Pro Pro Pro Arg Val Val Asp Thr Leu Gly Ala 
                 245                250                255
Gly Asp Thr Phe Asn Ala Ser Val Ile Phe Ser Leu Ser Gln Gly Arg 
             260                265                270
Ser Val Gln Glu Ala Leu Arg Phe Gly Cys Gln Val Ala Gly Lys Lys 
         275                280                285
Cys Gly Leu Gln Gly Phe Asp Gly Ile Val 
     290                295



<210> 4019
<211> 1182
<212> DNA
<213> Rattus norvegicus
<308> M86564
<400> 4019

gttcccggg  cgtgctccg  gctcactgc  gccaccttc  ccgcccacc  tctcctcca  60
cgcggactc  ggcagcttt  tcgccagag  cctcgaaac  cgactaatt  cttacgcgt  120
cgaccagac  accggcgtg  cccaccatg  cagacgcgg  agtggacac  agctccgag  180
tcaccacca  ggacttgaa  gagaagaag  aagttgtgg  ggaggcaga  aatggaaga  240
acgcacctg  caatgggaa  gctcaaaat  aggaaaatg  ggagcagga  gctgacaat  300
aggtagatg  agaagagga  gaaggtggg  aggaagagg  ggaggagga  gaaggtgat  360
gtgaggaag  agatggaga  gaagatgag  aagctgagg  tcctacggg  aagcgggta  420
ctgaggatg  tgaggatga  gatgttgag  ccaagaagc  gaagaagac  gatgaggat  480
actagacag  aaaaggaaa  gctaacctt  cgcaccgtg  cctattcac  ctccacttc  540
cgtctcaga  tttaaacgt  gtcaccttc  agtagagaa  caggccccc  cccgcccac  600
gcgcgagtg  cacccacca  tgacatgcg  tcttcacca  cccaccaaa  ccacaacat  660
aattggcaa  atgggagga  aaaagaacc  gaacttccc  ggccctgct  tttttctta  720
aaatacttt  aaaggaaaa  ttgtttgta  tttttattt  cattttata  ttttgtaca  780
attgttagg  gtcagccat  tttaatgat  acgggtgac  aaaccagcc  tcagagcgt  840
ttctgtcct  cttcagact  tacttgtgg  gtgaccatg  tcattatac  ctcaaagga  900
aaaaaaaac  ttgtaaaaa  aacaaaaac  acaacaaaa  aacaatctt  ttctgagca  960
tccagtaac  ttttttgtg  atgtaccta  ctgtactat  agtagttgg  ttgtatgag  1020
tggttaaaa  ggccaaaga  aaaaagatt  tttttcctt  ttttttgtc  atgaagttg  1080
tgtttattt  tttggcctg  ttgatgtat  tgtgaaaca  tgtccaaca  taaaccgga  1140
ttttatttt  ctgagttgt  ccaaaaaaa  aaaaaggaa  cc  1182



<210> 4020
<211> 111
<212> PRT
<213> Rattus norvegicus
<308> P06302
<400> 4020

Ser Asp Ala Ala Val Asp Thr Ser Ser Glu Ile Thr Thr Lys Asp Leu 
  1               5                  10                  15
Lys Glu Lys Lys Glu Val Val Glu Glu Ala Glu Asn Gly Arg Asp Ala 
             20                  25                  30
Pro Ala Asn Gly Asn Ala Gln Asn Glu Glu Asn Gly Glu Gln Glu Ala 
         35                  40                  45
Asp Asn Glu Val Asp Glu Glu Glu Glu Glu Gly Gly Glu Glu Glu Glu 
     50                  55                  60
Glu Glu Glu Glu Gly Asp Gly Glu Glu Glu Asp Gly Asp Glu Asp Glu 
 65                  70                  75                  80
Glu Ala Glu Ala Pro Thr Gly Lys Arg Val Ala Glu Asp Asp Glu Asp 
                 85                  90                  95
Asp Asp Val Glu Thr Lys Lys Gln Lys Lys Thr Asp Glu Asp Asp 
             100                105                110



<210> 4021
<211> 473
<212> DNA
<213> Homo sapiens
<308> AI859111
<400> 4021

ttttttttt  tttagaaca  ctcagcaaa  taaaattcc  gtttattgt  ggacaacat  60
gtttcacac  tacatcaaa  aggccaaaa  aaataaaca  caacttcat  gacaaaaaa  120
gaaaaaaaa  aaacctttt  tctttggcc  ttttaacca  ctcatacaa  ccaactact  180
atagtacag  taagtacat  cacaaaaaa  ttactggaa  gctcggaat  agattgttt  240
tctgttgtc  tttttgctt  ttttacaag  ttttttttc  cctttgaga  tataatgaa  300
atggtcaca  cacaagtaa  gtcagaagt  ggacagaga  cgctccgaa  gctggtttg  360
tcatccgag  tcattaaaa  tggctgacc  taacaatat  tacaaaaat  taaaatgta  420
ataaaaaat  caaacaaat  tccttttta  agtactttt  agaaaaaaa  cag  473



<210> 4022
<211> 3295
<212> DNA
<213> Rattus norvegicus
<308> M86912
<400> 4022

aagcttgct  atgtctgat  ggccactta  cactacgta  gcacatgct  tagaaaagt  60
ggccgccgt  gattttatc  gctcacaag  tttcttcgg  aaatatggt  taaagtttt  120
tccaaagcg  aaagtagaa  cactagatt  gtggtggaa  atgaaattt  cttatttac  180
atcggaact  ataattttt  actttttaa  gttctttgg  tttttgttt  tttccaggt  240
aagtggatt  cgaatagtg  ctgagacca  ctcaaccca  aaaaacaaa  tggccctta  300
ctcttctgc  gaagatggt  tcaaaagaa  ccaagatga  tgccccaag  ctggcaggc  360
cagttacat  tttgtcatg  tccctaccc  ctacagcat  atctttgtg  tgggaatat  420
tggaaacag  ttggtggtg  ttgtcattt  cttttacat  aagctgaag  ctgtggcca  480
cgtctttct  ctcaatctc  ccttggctg  cttatgctt  ttgctgact  tgcccctgt  540
ggcagtcta  accgctatg  agtaccgct  gcccttcgg  aatcaccta  gtaagatcg  600
ttcggccag  gtgagcttc  acctctacg  cagtgtgtt  cttctcacg  gtctcagca  660
cgaccgcta  ctggccatc  tccacccaa  gaagtctcg  cttcgccgc  cgatgctgg  720
ggccaaagt  acctgcatc  tcatctggc  gatggctgg  ttggccagt  tgccagctg  780
catccaccg  aatgtatac  tcatcgaga  caccaatat  acagtgtgc  cgtttcatt  840
tgagtctcg  aattcgacg  tccccatag  gctgggcct  accaagaat  ttctgggct  900
cttgttccc  ttccttatc  ttctcacca  ctataccct  atttggaaa  ctctaaaga  960
ggcttatga  attcaaaag  acaaaccaa  aaacgatga  atctttagg  taattatgg  1020
gattgtgct  ttcttcttc  tttcctggg  cccccacca  atattcact  tcctggatg  1080
gctgattca  ctgggcgtc  tccatgact  taaaatttc  gacatcgtg  acactgcca  1140
gcccatcac  atctgcata  cgtatttta  caactgcct  aaccctctg  tctacggct  1200
tctggggaa  aaatttaaa  agtatttcc  ccagctcct  aaatatatt  ccccaaagg  1260
caagtccca  tcaagcctg  ctacgaaaa  gagcacgct  tcttaccgg  cttcggata  1320
catgagctc  tcggccaaa  agcctgcgt  ttgttttga  gtggagtga  aggttcaaa  1380
cacactggc  atgtaatgc  ctgacagaa  ccagggcag  ctctgacta  atggcttac  1440
accaaagga  cattcaccc  gcctcagga  ctaagcaga  aatgcgctc  tcagactgt  1500
gataatgac  aaaactctg  gagaagact  tgaaggagt  accaagcaa  gccgtcttg  1560
attaataga  gatggctag  caaaggaag  gtcaggagc  ggatggatt  gtgggtctg  1620
aaaacagtt  gctggcaga  atgcaatct  atcagtctc  ctttgctat  ttccttttg  1680
tttccacac  taggtatgt  gcccatgct  aatatttag  caagaaaca  gagatggaa  1740
tcaaggtca  ttgttctgt  caactccca  agggcaagg  acctttgtt  tccctgtag  1800
cattagcag  ggagaccca  ttgtcactg  tactacacc  atcgtgcaa  gatttgcta  1860
tctgtagtt  tcaagtttc  ggactcctt  gtaaaattc  gccagtgtt  tagaaacat  1920
tactgtccc  agacaatgc  agccagtgg  gtacttatg  agcagtgtt  cccaagtcc  1980
cacatcaaa  tcacactgc  ttaataacg  gacatacta  gtacatctg  gttatttcg  2040
atctgagaa  tgtacacag  cagaggtga  tacactata  tccatacag  ctgccttgc  2100
ctctaaaaa  atatattct  cacatacgt  aacatcttt  tctctaaac  gtcatttga  2160
gaaattttg  caatgtatg  ttacctcta  ataaagtaa  tttattgta  tgtatctaa  2220
cttcattat  taaaataga  gcctatcta  ttttacaat  acatggata  aagtaaaaa  2280
acaaaatta  aataatgca  ttttacttc  agtttgatc  ggttgatag  ttaatatgg  2340
tagatatag  ttttatatc  cactgttga  aaaatcatg  aggccagct  gtaccccac  2400
atgtaggga  gatacaaca  ttttaattt  tttagttat  catataaca  caaaaacat  2460
ttcattgct  ttaacatta  attaatact  ttttttact  ataagtttt  gttacatct  2520
gttacatgc  tggtaattg  aggaaatat  gaagctctg  aaaacacaa  gcaatagtc  2580
tatttagtt  ttcagtgca  aaatactcc  ttttagtat  ttagcccat  agtaggaag  2640
agagggtga  ttgtaaggc  tcatgtctt  tgcaacctc  aagcccacc  cagtgacag  2700
tacatgtgc  tcaccaggt  tgtcagact  actaatccc  cagtcctgc  cagccacca  2760
ctggggatc  agttttcat  ctcactata  atacataca  atgtaaatt  tggtgttag  2820
gccataatg  atatacaat  ctgtatata  gcttgtccc  cagtgtcat  gcagagtac  2880
tagtatacc  ttcaatgta  ttcctcaaa  attccagta  tgttaaaaa  cacaagcac  2940
cctgataac  ttagggaat  accaaattg  agcatttac  attcttcta  aaatacttt  3000
ggcactaga  gtcaccctg  gctgatcaa  cacacaaat  tgataaact  caagaagaa  3060
cagaactga  aatatggtt  taaacgttt  tcgtattcc  aatatgtaa  agcacgttt  3120
ccagaaagt  taacacaac  tatatacgc  accagctat  tttagctgt  gctcatggc  3180
agctcagtg  agaggagtt  acttcctct  agaacccag  tgctgtagg  tagaacagg  3240
aacaaacta  accagaata  tgccatggg  cggctgcct  gtcaccaga  agctt  3295



<210> 4023
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> CAA44183
<400> 4023

Met Ala Leu Asn Ser Ser Ala Glu Asp Gly Ile Lys Arg Ile Gln Asp 
  1               5                  10                  15
Asp Cys Pro Lys Ala Gly Arg His Ser Tyr Ile Phe Val Met Ile Pro 
             20                  25                  30
Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu 
         35                  40                  45
Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr Val Ala Ser 
     50                  55                  60
Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr 
 65                  70                  75                  80
Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe 
                 85                  90                  95
Gly Asn His Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu 
             100                105                110
Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu 
         115                120                125
Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu Val 
     130                135                140
Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Met Ala Gly Leu Ala Ser 
 145                150                155                160
Leu Pro Ala Val Ile His Arg Asn Val Tyr Phe Ile Glu Asn Thr Asn 
                 165                170                175
Ile Thr Val Cys Ala Phe His Tyr Glu Ser Arg Asn Ser Thr Leu Pro 
             180                185                190
Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe 
         195                200                205
Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala Leu Lys Lys 
     210                215                220
Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Arg 
 225                230                235                240
Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Val Pro His 
                 245                250                255
Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly Val Ile His 
             260                265                270
Asp Cys Lys Ile Ser Asp Ile Val Asp Thr Ala Met Pro Ile Thr Ile 
         275                280                285
Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe 
     290                295                300
Leu Gly Lys Lys Phe Lys Lys Tyr Phe Leu Gln Leu Leu Lys Tyr Ile 
 305                310                315                320
Pro Pro Lys Ala Lys Ser His Ser Ser Leu Ser Thr Lys Met Ser Thr 
                 325                330                335
Leu Ser Tyr Arg Pro Ser Asp Asn Met Ser Ser Ser Ala Lys Lys Pro 
             340                345                350
Ala Ser Cys Phe Glu Val Glu 
         355



<210> 4024
<211> 1563
<212> DNA
<213> Homo sapiens
<308> D13814
<400> 4024

aggtacctt  acaggcagc  gcgaagtga  caggacgtc  tggaccgtc  cgccgctag  60
tagctactt  gggccgtgg  ggtgatcga  ggcgagcgg  tgatgcgga  cctcgacgt  120
aagggcgag  gcctgacgc  aggcggcgg  gcggtagac  cgacataga  cgcctgtct  180
ggacgtacg  cgccgtgcc  ctcttatta  atagtgttt  acaatcgac  aggtgatca  240
tgatcctca  ctcttctac  gaagatggt  ttaaaagaa  ccaagatga  tgtcccaaa  300
ctggaaggc  taattacat  tttgtcatg  ttcctactt  atacagtat  atctttgtg  360
tgggaatat  tggaaacag  ttggtggtg  tagtcattt  cttttatat  aagctgaag  420
ctgtggcca  tgtttttct  ttgaattta  cactggctg  cttatgctt  ttactgact  480
tgccactat  ggctgtcta  acagctatg  aataccgct  gccctttgg  aattaccta  540
gtaagattg  ttcagccag  gtcagtttc  acctgtacg  tagtgtgtt  ctactcacg  600
gtctcagca  tgatcgata  ctggctatt  ttcacccaa  gaagtcccg  cttcgacgc  660
caatgcttg  agccaaagt  acctgcatc  tcatttggc  gctggcagg  ttggccagt  720
tgccagcta  aatccatcg  aatgtattt  tcattgaga  caccaatat  acagtttgt  780
ccttccatt  tgagtcccg  aattcaacc  tcccgatag  gctgggcct  accaaaaat  840
tactgggtt  ctgtttccc  tttctgatc  ttcttacaa  ttatactct  atttggaag  900
ccctaaaga  ggcttatga  attcagaag  acaacccaa  aaatgatga  atttttagg  960
taattatgg  aattgtgct  ttctttttc  tttcctgga  tccccacca  atattcact  1020
ttctggatg  attgattca  cagggcatc  tacgtgact  tagaattgc  gatattgtg  1080
acacggcca  gcccatcac  atttggata  cttatttta  caattgcct  aatcctctg  1140
tttatggct  tctgggaaa  aaatttaaa  aagatattc  ccagcttct  aaatatatt  1200
ccccaaagg  caaatccca  tcaaacctt  caacaaaaa  gagcacgct  tcctaccgc  1260
cctcagata  tgtaagctc  tccaccaag  agcctgcac  atgttttga  gttgagtga  1320
atgttcgaa  cctgtccat  aagtaattt  gtgaaagaa  gagcaagag  acattcctc  1380
gcagcactt  actaccaaa  gagccttag  tacttttca  aattgaagg  gaaatgcat  1440
atgtggact  aaccgactt  tctaaagct  tgaacaaaa  cttttcttt  cttttgcaa  1500
aagacaaag  aaagccaca  tttgcatta  acagatgac  gctgctcga  gaacaatgt  1560
aga  1563



<210> 4025
<211> 359
<212> PRT
<213> Homo sapiens
<308> P30556
<400> 4025

Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile Gln Asp 
  1               5                  10                  15
Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro 
             20                  25                  30
Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu 
         35                  40                  45
Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr Val Ala Ser 
     50                  55                  60
Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr 
 65                  70                  75                  80
Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe 
                 85                  90                  95
Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu 
             100                105                110
Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu 
         115                120                125
Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu Val 
     130                135                140
Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser 
 145                150                155                160
Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Thr Asn 
                 165                170                175
Ile Thr Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Thr Leu Pro 
             180                185                190
Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe 
         195                200                205
Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala Leu Lys Lys 
     210                215                220
Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Lys 
 225                230                235                240
Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His 
                 245                250                255
Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly Ile Ile Arg 
             260                265                270
Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met Pro Ile Thr Ile 
         275                280                285
Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe 
     290                295                300
Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu Lys Tyr Ile 
 305                310                315                320
Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Thr Lys Met Ser Thr 
                 325                330                335
Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys Pro 
             340                345                350
Ala Pro Cys Phe Glu Val Glu 
         355



<210> 4026
<211> 2525
<212> DNA
<213> Rattus norvegicus
<308> M88751
<400> 4026

cgggggcgg  gcggctcgg  ggcatctcg  gcgcggccc  ccgtcctcg  ccccggcgc  60
gctcgctcc  cccacccca  cccggactc  cccatgtat  acgactcct  cgtgcccgg  120
tttgaggac  cggaggcgg  ttcagccga  tcctacacc  gccgcccct  tctggactc  180
gacgtttcc  tggaggagg  ccgggagag  gcccggcga  aagtggaga  tcaggctca  240
cagcagctg  aaagagcca  gcacaaacc  gtggcattt  ctgtgagga  caatgtcag  300
tactgtgga  ttctggatg  ggaatgccc  gtccagggc  ctggagtca  cttcgaggc  360
aaagatttt  tgcacatta  agagaagta  agcaatgac  ggtggatcg  gaggctagt  420
aaagaaggt  gcgatattg  cttcatccc  agcccccaa  gcctggaga  catccggct  480
aaacaggaa  agaaggcca  gagatccgg  aacccttcc  gcctgagtg  cattggcaa  540
cgacgttcc  ctcctccat  tctagccaa  cagaagcaa  agcaggcgg  acatgtccc  600
ccgtatgat  tggtgccct  catgcggcc  gtggtgctg  tgggaccct  tctgaaagg  660
tatgaggtc  cagacatga  gcagaaggc  ctcttcgac  tccttaaac  caggtttga  720
ggcaggatc  ccatcaccc  cgtcacggc  gacctctca  tggccaagc  ctctgtgct  780
aacaatcct  gcaagagga  catcatcga  cgctcttct  cccgctcca  cattgctga  840
gtgcagagt  agattgagc  catattcga  ctggccaaa  ccctgcagc  agtggtgtt  900
gatgctgac  ccatcaacc  cccagcaca  ctagccaag  cctcactgg  ccccatcat  960
gtcttcgtc  aagtgtcct  gccaaaggt  ctgcagcga  tgatccgct  cagggggaa  1020
tcccagatg  agcacctca  tgtacagat  atggcatat  ataagctgg  tcagtgccc  1080
cctgagtca  ttgatgtga  tctggatga  aaccagctg  acgacgcct  tgagcacct  1140
gctgaatac  tagaggttt  ctggcgcgc  acccaccac  cagcaccgg  ccccgggat  1200
ctgggtccg  ccagtgcca  ccctggact  cagaaccag  agctgctgg  ggagcgagg  1260
gaggagcat  cacccctgg  gcgggacag  ttgatgccc  cggatgagg  cagtgagag  1320
tcccgccag  cctggaccg  atcttcaca  cgcagctcc  gccatctgg  ggaggacta  1380
gcagatgcc  accaggacc  gtaccagcc  caccgtcaa  acacctcgg  gctacccag  1440
gctaacggg  atgaccccc  agaccggct  ctagcccag  actcggagc  tgaccacaa  1500
gaccggaac  ggcagcgta  ccggccttg  cctaaggac  gctactgac  acctcctgc  1560
ctaccctgg  aggcacaga  acagcggct  gggtgtcca  ctcaggcag  ttggagtta  1620
attggcgtt  ggctgcctc  aggttcagc  cacacaacc  tctgcccag  cctaggtcc  1680
gggctgact  tggtcccaa  gttctggga  aagcaaggg  ccccctcac  tcctgggca  1740
agtgacccc  taggttctc  tccaggtac  agctgtgtt  tgcatcctt  gcaccttcc  1800
ctgcataag  agctgcccc  gtgagcaat  atctcaggc  gggatcact  agcaggggt  1860
ttccagcca  aatggatac  cctctaaac  gcaggaggg  gtgagtgca  gcaatgtag  1920
atgaggaag  gacatggtt  ctgagcagg  gtaaaccct  agcaaagga  ctccgttca  1980
gtcactgcc  cacattaga  atgaagcaa  cagagctca  catggcggc  cttctatcc  2040
atcagctgg  gtgggcact  acacctaag  caggagcag  gcaggtgag  caggacaga  2100
agctcatgg  tgtagctct  ttagagaac  gccctcctc  ccaaaccag  aagcttagc  2160
tctggcaag  ctagggaac  ggggcacag  caagcccaa  gccggcctg  actgcgggg  2220
agggggagc  gcttccagc  cccccaccc  ccttgcttt  ctcattctt  gcccttgcg  2280
ctgtcattt  tgttccttc  ctccatgcc  cctgcaaga  aggggctcc  tggctcgta  2340
ctgccactt  ttaagttag  gttagatga  aggaacaga  acaatgaac  gccccagag  2400
ctgtcacct  gctaccctt  ccttatggc  ctagcgttt  acctacaga  catgctcca  2460
taagaaccc  ccccacctc  ttgtcatct  caataaaac  taacgcaca  tcccttggg  2520
gtctc  2525



<210> 4027
<211> 484
<212> PRT
<213> Rattus norvegicus
<308> P54287
<400> 4027

Met Tyr Asp Asp Ser Tyr Val Pro Gly Phe Glu Asp Ser Glu Ala Gly 
  1               5                  10                  15
Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Leu Asp Ser Asp Val Ser 
             20                  25                  30
Leu Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu Ser Gln Ala 
         35                  40                  45
Gln Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala Phe Ala Val 
     50                  55                  60
Arg Thr Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu Cys Pro Val 
 65                  70                  75                  80
Gln Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu His Ile Lys 
                 85                  90                  95
Glu Lys Tyr Ser Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly 
             100                105                110
Gly Asp Ile Ala Phe Ile Pro Ser Pro Gln Arg Leu Glu Ser Ile Arg 
         115                120                125
Leu Lys Gln Glu Gln Lys Ala Arg Arg Ser Gly Asn Pro Ser Ser Leu 
     130                135                140
Ser Asp Ile Gly Asn Arg Arg Ser Pro Pro Pro Ser Leu Ala Lys Gln 
 145                150                155                160
Lys Gln Lys Gln Ala Glu His Val Pro Pro Tyr Asp Val Val Pro Ser 
                 165                170                175
Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu Val 
             180                185                190
Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg Phe 
         195                200                205
Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Leu Ser Leu Ala 
     210                215                220
Lys Arg Ser Val Leu Asn Asn Pro Gly Lys Arg Thr Ile Ile Glu Arg 
 225                230                235                240
Ser Ser Ala Arg Ser Ser Ile Ala Glu Val Gln Ser Glu Ile Glu Arg 
                 245                250                255
Ile Phe Glu Leu Ala Lys Ser Leu Gln Leu Val Val Leu Asp Ala Asp 
             260                265                270
Thr Ile Asn His Pro Ala Gln Leu Ala Lys Thr Ser Leu Ala Pro Ile 
         275                280                285
Ile Val Phe Val Lys Val Ser Ser Pro Lys Val Leu Gln Arg Leu Ile 
     290                295                300
Arg Ser Arg Gly Lys Ser Gln Met Lys His Leu Thr Val Gln Met Met 
 305                310                315                320
Ala Tyr Asp Lys Leu Val Gln Cys Pro Pro Glu Ser Phe Asp Val Ile 
                 325                330                335
Leu Asp Glu Asn Gln Leu Asp Asp Ala Cys Glu His Leu Ala Glu Tyr 
             340                345                350
Leu Glu Val Tyr Trp Arg Ala Thr His His Pro Ala Pro Gly Pro Gly 
         355                360                365
Met Leu Gly Pro Pro Ser Ala Ile Pro Gly Leu Gln Asn Gln Gln Leu 
     370                375                380
Leu Gly Glu Arg Gly Glu Glu His Ser Pro Leu Glu Arg Asp Ser Leu 
 385                390                395                400
Met Pro Ser Asp Glu Ala Ser Glu Ser Ser Arg Gln Ala Trp Thr Gly 
                 405                410                415
Ser Ser Gln Arg Ser Ser Arg His Leu Glu Glu Asp Tyr Ala Asp Ala 
             420                425                430
Tyr Gln Asp Leu Tyr Gln Pro His Arg Gln His Thr Ser Gly Leu Pro 
         435                440                445
Ser Ala Asn Gly His Asp Pro Gln Asp Arg Leu Leu Ala Gln Asp Ser 
     450                455                460
Glu His Asp His Asn Asp Arg Asn Trp Gln Arg Asn Arg Pro Trp Pro 
 465                470                475                480
Lys Asp Ser Tyr 
                 485



<210> 4028
<211> 1392
<212> DNA
<213> Homo sapiens
<308> X76556
<400> 4028

gctcgctcc  ccgacccgg  ctcccccat  tatgacgac  cctacgtgc  cgggtttga  60
gactcggag  cgggttcag  cgactccta  accagccgc  catctctgg  ctcagacgt  120
tccctggag  aggaccggg  gagtgcccg  cgtgaagta  agagccagg  tcagcagca  180
ctcgaaagg  ccaagcaca  acctgtggc  tttgcggtg  ggaccaatg  cagctactg  240
ggcgtactg  atgaggagt  cccagtcca  ggctctgga  tcaactttg  ggccaaaga  300
tttctgcac  ttaaagaga  gtacagcaa  gactggtgg  tcgggcggc  agtgaaaga  360
ggcggggac  tcgccttca  ccccagccc  cagcgcctg  agagcatcc  gctcaaaca  420
gagcagaag  ccaggagat  tgggaaccc  tccagcctg  gtgacattg  caaccgacg  480
tcccctccg  catctctag  caagcagaa  caaaagcag  cggaacatg  tcccccata  540
gacgtggtg  cctccatgc  gcctgtggt  ctggtggga  cctctctga  aggttatga  600
gtcacagac  tgatgcaga  ggctctctt  gacttcctc  aacacagat  tgatggcag  660
atctccatc  cccgagtca  agccgacct  tccctggca  agcgatctg  gctcaacaa  720
ccgggcaag  ggaccatca  tgagcgctc  tctgcccgc  ccagcattg  ggaagtgca  780
agtgagatc  agcgcatat  tgagctggc  aaatccctg  agctagtag  gttggacgc  840
gacaccatc  accacccag  acagctggc  aagacctcg  tggccccca  catcgtctt  900
gtcaaagtg  cctcaccaa  ggtactcca  cgtctcatt  gctcccggg  gaagtcaca  960
atgaagcac  tgaccgtac  gatgatggc  tatgataag  tggttcagt  cccaccgga  1020
tcatttgat  tgattctgg  tgagaacca  ctggaggat  cctgtgagc  cctggctga  1080
tacctggag  tttactggc  ggccacgca  cacccagcc  ctggccccg  acttctggg  1140
cctcccagt  ccatccccg  acttcagaa  cagcagctg  tgggggagc  tggcgagga  1200
cactccccc  ttgagcggg  cagcttgat  ccctctgat  aggccagcg  gagctcccg  1260
caagcctgg  caggatctt  acagcgtag  tcccgccac  tggaggagg  ctatgcaga  1320
gcctaccag  acctgtacc  gccccaatg  caactctta  gtcttttgt  attctggct  1380
tctctaata  aa  1392



<210> 4029
<211> 484
<212> PRT
<213> Homo sapiens
<308> P54284
<400> 4029

Met Tyr Asp Asp Ser Tyr Val Pro Gly Phe Glu Asp Ser Glu Ala Gly 
  1               5                  10                  15
Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Leu Asp Ser Asp Val Ser 
             20                  25                  30
Leu Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu Ser Gln Ala 
         35                  40                  45
Gln Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala Phe Ala Val 
     50                  55                  60
Arg Thr Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu Cys Pro Val 
 65                  70                  75                  80
Gln Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu His Ile Lys 
                 85                  90                  95
Glu Lys Tyr Ser Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly 
             100                105                110
Gly Asp Ile Ala Phe Ile Pro Ser Pro Gln Arg Leu Glu Ser Ile Arg 
         115                120                125
Leu Lys Gln Glu Gln Lys Ala Arg Arg Ser Gly Asn Pro Ser Ser Leu 
     130                135                140
Ser Asp Ile Gly Asn Arg Arg Ser Pro Pro Pro Ser Leu Ala Lys Gln 
 145                150                155                160
Lys Gln Lys Gln Ala Glu His Val Pro Pro Tyr Asp Val Val Pro Ser 
                 165                170                175
Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu Val 
             180                185                190
Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg Phe 
         195                200                205
Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Leu Ser Leu Ala 
     210                215                220
Lys Arg Ser Val Leu Asn Asn Pro Gly Lys Arg Thr Ile Ile Glu Arg 
 225                230                235                240
Ser Ser Ala Arg Ser Ser Ile Ala Glu Val Gln Ser Glu Ile Glu Arg 
                 245                250                255
Ile Phe Glu Leu Ala Lys Ser Leu Gln Leu Val Val Leu Asp Ala Asp 
             260                265                270
Thr Ile Asn His Pro Ala Gln Leu Ala Lys Thr Ser Leu Ala Pro Ile 
         275                280                285
Ile Val Phe Val Lys Val Ser Ser Pro Lys Val Leu Gln Arg Leu Ile 
     290                295                300
Arg Ser Arg Gly Lys Ser Gln Met Lys His Leu Thr Val Gln Met Met 
 305                310                315                320
Ala Tyr Asp Lys Leu Val Gln Cys Pro Pro Glu Ser Phe Asp Val Ile 
                 325                330                335
Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Glu Tyr 
             340                345                350
Leu Glu Val Tyr Trp Arg Ala Thr His His Pro Ala Pro Gly Pro Gly 
         355                360                365
Leu Leu Gly Pro Pro Ser Ala Ile Pro Gly Leu Gln Asn Gln Gln Leu 
     370                375                380
Leu Gly Glu Arg Gly Glu Glu His Ser Pro Leu Glu Arg Asp Ser Leu 
 385                390                395                400
Met Pro Ser Asp Glu Ala Ser Glu Ser Ser Arg Gln Ala Trp Thr Gly 
                 405                410                415
Ser Ser Gln Arg Ser Ser Arg His Leu Glu Glu Asp Tyr Ala Asp Ala 
             420                425                430
Tyr Gln Asp Leu Tyr Gln Pro His Arg Gln His Thr Ser Gly Leu Pro 
         435                440                445
Ser Ala Asn Gly His Asp Pro Gln Asp Arg Leu Leu Ala Gln Asp Ser 
     450                455                460
Glu His Asn His Ser Asp Arg Asn Trp Gln Arg Asn Arg Pro Trp Pro 
 465                470                475                480
Lys Asp Ser Tyr 
                 485



<210> 4030
<211> 2509
<212> DNA
<213> Rattus norvegicus
<308> M89953
<400> 4030

gatcctggg  aaaaggatg  tgctgggag  gcacctctg  atcagttgg  ttctttttg  60
ctctggttt  aaaagctct  tggaagaga  ctgatgtct  gaatcttct  agtatgaac  120
ggggaatgc  gaagttttg  agttaaata  gtcaatgtc  ttatgtttc  aaaagcatt  180
gaatgtcga  ggcaagaac  ccagaaccc  gcccatcct  ctgtgagac  ttgataatt  240
tctaacaaa  ctaacaaaa  actgggctg  accatctgc  gggagaagt  ccagaaccc  300
aagaggcct  gggcttcat  tgcttccgg  agcatctag  tgtggagtt  gtgtccttt  360
ctgggcacg  cttgaggcc  ttctgctga  ctctgtcct  atgtatggc  ttcacagtt  420
tgaagctga  gtatgactt  gttctctgg  tgggatgag  gtgaaggag  gagccgtgt  480
tgtagaagt  tgtgggaag  gagaaacac  gagcatgtc  ctgccaaac  agtccctag  540
aggccttcc  caggaggcc  ccaacagat  cctgaatgc  acaggggct  gggacccag  600
ggtcctgca  gcactcaga  tctccctcg  ggtggtcct  tccatcatt  cactggcca  660
tgtcctctc  aatgccttc  tacttacca  catcctgct  accaagaag  tccataccc  720
agccaacta  ctcattggc  ccttggcca  caccgacct  ctggtttct  tcttggtca  780
gcccatcag  atagcctat  ccaccaccc  tacctggaa  tttggccag  tcctgtgtg  840
catctgggt  tcttctgac  tcacatgct  tacggcctc  atcctgcat  tctgtgtca  900
cgctctgga  agatactgg  ccatcaccg  tgccctgga  tacagcaag  gccggaccg  960
aggtcacgc  gcggccatg  ttgcggccg  ctgggccat  tccatctgt  tctccatcc  1020
accgctctt  tggcggcag  ccacggctc  cgaggagat  tctgactgc  tggtgaaca  1080
atctcagat  tcttacacc  tctactcga  ctgtggggc  ttctacatc  catccatct  1140
gctcattat  ctgtatggc  gcatatacg  ggccgcccg  agtcgaatc  tgaacccac  1200
ctccctcta  gggaagcgc  tcaccacag  acagcttat  acgggctct  cgggctctt  1260
actctgctc  ctcaacccc  gcctccacg  gagccacac  cacacagtc  gttcccctc  1320
ttttttcaa  caggtgaaa  tcaagcttg  tgatagcat  ttagaacgc  agaggatct  1380
tgcagcccg  gaaaggaaa  ccactaaga  attgggcat  attctgggg  cctttatca  1440
ctgctggct  cctttcttt  tggtatcct  ggtcctccc  atctgcagg  actcctgtt  1500
gatccaccc  gccctcttt  acttcttca  gtggctagg  tatttaaac  ctctcatta  1560
ccccgtcat  tacactgtg  tcaacgaag  ctttcgaca  gcgtttcag  gagtcgtcc  1620
tttccgaaa  gcctcttag  cgaatttgg  ggtgactct  gtttatctg  tatgtcctg  1680
aacccagct  gggttgcct  ttttaatta  tgtcgtttc  ctgggacct  ggctgattt  1740
tgctatctt  ggtcttgga  taaatcaat  gatttgttc  gtgtttgac  gccagcatc  1800
tccagactt  tgaattact  aaagctagg  gctgtgtaa  aggcgacag  actgaaaga  1860
atcccttaa  ataatatcc  catggttct  tggattgga  gaaatttaa  atgtaggac  1920
tagatgaga  actgtctta  tctctagaa  gctcggagg  aaggccttc  ggtctacct  1980
ggattttac  gagggcttt  gaaaatggg  gtgattatt  acttgaatt  aagtgaatt  2040
ggagttaaa  agagggggt  gtcatctcc  atagcccac  gattagaaa  caacaccca  2100
gaattgttt  tactgggtc  tggttgtcc  tatggaaag  gaggttggt  acccagggt  2160
gatagagag  aattcagaa  gtggcagca  gaagagagg  atacgtggg  ccagatcaa  2220
tactctaca  ccttcattc  tccctttgt  tctattata  aatgttctg  agttaaaac  2280
cgtcatcct  ctgctcaag  agactgacc  gtgtcggat  caccaagct  tgaacggat  2340
cctcattct  cccattccg  tgtttttat  ttgaattac  attttttta  aacccttgt  2400
gggctggag  gatggctta  cagttaaga  cactgactg  tcttccaga  gtcctgagt  2460
caaatccca  caactgcat  gtggctcac  acccttgtc  tcagaattc  2509



<210> 4031
<211> 374
<212> PRT
<213> Rattus norvegicus
<308> AAA40614
<400> 4031

Met Ser Leu Pro Asn Gln Ser Leu Glu Gly Leu Pro Gln Glu Ala Ser 
  1               5                  10                  15
Asn Arg Ser Leu Asn Ala Thr Gly Ala Trp Asp Pro Glu Val Leu Gln 
             20                  25                  30
Ala Leu Arg Ile Ser Leu Val Val Val Leu Ser Ile Ile Thr Leu Ala 
         35                  40                  45
Thr Val Leu Ser Asn Ala Phe Val Leu Thr Thr Ile Leu Leu Thr Lys 
     50                  55                  60
Lys Leu His Thr Pro Ala Asn Tyr Leu Ile Gly Ser Leu Ala Thr Thr 
 65                  70                  75                  80
Asp Leu Leu Val Ser Ile Leu Val Met Pro Ile Ser Ile Ala Tyr Thr 
                 85                  90                  95
Thr Thr Arg Thr Trp Asn Phe Gly Gln Ile Leu Cys Asp Ile Trp Val 
             100                105                110
Ser Ser Asp Ile Thr Cys Cys Thr Ala Ser Ile Leu His Leu Cys Val 
         115                120                125
Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asp Ala Leu Glu Tyr Ser 
     130                135                140
Lys Arg Arg Thr Ala Gly His Ala Ala Ala Met Ile Ala Ala Val Trp 
 145                150                155                160
Ala Ile Ser Ile Cys Ile Ser Ile Pro Pro Leu Phe Trp Arg Gln Ala 
                 165                170                175
Thr Ala His Glu Glu Met Ser Asp Cys Leu Val Asn Thr Ser Gln Ile 
             180                185                190
Ser Tyr Thr Ile Tyr Ser Thr Cys Gly Ala Phe Tyr Ile Pro Ser Ile 
         195                200                205
Leu Leu Ile Ile Leu Tyr Gly Arg Ile Tyr Val Ala Ala Arg Ser Arg 
     210                215                220
Ile Leu Asn Pro Pro Ser Leu Tyr Gly Lys Arg Phe Thr Thr Ala Gln 
 225                230                235                240
Leu Ile Thr Gly Ser Ala Gly Ser Ser Leu Cys Ser Leu Asn Pro Ser 
                 245                250                255
Leu His Glu Ser His Thr His Thr Val Gly Ser Pro Leu Phe Phe Asn 
             260                265                270
Gln Val Lys Ile Lys Leu Ala Asp Ser Ile Leu Glu Arg Lys Arg Ile 
         275                280                285
Ser Ala Ala Arg Glu Arg Lys Ala Thr Lys Thr Leu Gly Ile Ile Leu 
     290                295                300
Gly Ala Phe Ile Ile Cys Trp Leu Pro Phe Phe Val Val Ser Leu Val 
 305                310                315                320
Leu Pro Ile Cys Arg Asp Ser Cys Trp Ile His Pro Ala Leu Phe Asp 
                 325                330                335
Phe Phe Thr Trp Leu Gly Tyr Leu Asn Ser Leu Ile Asn Pro Val Ile 
             340                345                350
Tyr Thr Val Phe Asn Glu Asp Phe Arg Gln Ala Phe Gln Arg Val Val 
         355                360                365
His Phe Arg Lys Ala Ser 
     370



<210> 4032
<211> 2864
<212> DNA
<213> Homo sapiens
<308> NM_000864
<400> 4032

ggcacgagg  taaatccag  atcgtttca  ttactgtga  gggaattct  aagttctca  60
taaacacac  aatgtctca  gctttgaaa  gagccagat  ccaaaggca  gaatcccag  120
gcattgccc  cctgggtgt  atcccctga  aattgtcta  caaattcag  atgtgtccc  180
tgggcatga  catctgctg  gaaaagttc  aggaccctg  gacatcttg  gattcctgt  240
gtttaggaa  gacctttaa  taccagctg  tagttgtct  agcattctt  aaatagtcc  300
gtcttgttt  atattatta  tattattgt  atttaattt  attttattg  aactgtact  360
agagaatag  ctggtcttg  gaccttttc  ctgtggtct  ttctggtgt  cggctccca  420
cagtgtgaa  cagaaggat  actttgctc  gttgtcagg  caaccttga  ggaaggagc  480
aaatgtgtg  aggtctgtg  gaagagaga  ccacctagc  tgtccccac  gaaccagtc  540
gcagaaggc  ttccccagg  ggcctccaa  agatccctg  atgccacag  aacctcaga  600
gcttgggat  ccaggaccc  ccaggcgct  aagatctcc  ttgccgtgg  cctttccgt  660
atcacactg  ccacagtcc  ctccaatgc  tttgtactc  ccaccatct  actcaccag  720
aagctccac  cccctgcca  ctacctgat  ggctccctg  ccaccaccg  cctcttggt  780
tccatcttg  taatgccca  cagcatcgc  tataccatc  cccacacct  gaactttgg  840
caaatcttg  gtgacatct  gctgtcctc  gacatcacg  gctgcacag  ctccatcct  900
catctctgt  tcattgctc  ggacaggta  tgggcaatc  cagatgccc  ggaatacag  960
aaacgcagg  cggctggcc  cgcggccac  atgatcgcc  ttgtctggg  catctccat  1020
tgcatctcc  tccccccgc  cttctggcg  caggccaag  cccaggagg  gatgtcgga  1080
tgtctggtg  acacctctc  gatttccta  accatctac  ccacctgtg  ggccttcta  1140
attccctcg  tgttgctca  catcctata  ggccggatc  accgggctg  ccggaaccg  1200
atcctgaat  caccctcac  ctatgggaa  cgcttcacc  cggcccacc  catcacagg  1260
tctgccggg  cctcgctct  ctcgctcaa  tccagcctc  atgaggggc  ctcgcactc  1320
gctggctcc  ctctctttt  caaccacgt  aaaatcaag  ttgctgaca  tgccctgga  1380
cgcaagagg  tttctgctg  tcgagaaag  aaagccact  aaatcctgg  catcattct  1440
ggggccttt  tcatctgct  gctgccctt  ttcgtggtg  ctctggtcc  ccccatctg  1500
cgggactcc  gctggatcc  cccggcgct  tttgacttc  tcacctggc  aggctattt  1560
aactccctc  tcaatccaa  aatctacac  gtgtttaat  aagagtttc  gcaagcttt  1620
cagaaaatt  tccctttcc  gaaggcctc  tagtcttat  cggtgatga  tcttgttat  1680
ttttgtgtc  tgtaacctc  tcgggattg  ctttttttt  taattattt  ctgagactt  1740
gattaattc  tggtatctt  agtcttggt  caatcaaca  aattgttct  tttcctgtt  1800
ttttcttaa  ttctgaaag  gctgtgggt  gtggggggc  gggggcagg  ctgaagatt  1860
cactactta  cataatatt  tctttcttt  ttttttttt  tgagacgga  tcttgccct  1920
tcgccaggc  ggagtgtag  ggcacaatc  cagctcact  caacctccg  atcccgggt  1980
caagagatt  tgcctcagc  tccagagta  ctgggacta  aaacgtgtg  caccaggcc  2040
agctaattt  tgtattttt  ataaagacg  ggtttcatc  tgttggcca  ggtggtctc  2100
atctcttga  ctcgtgatc  gcccgcctc  gcatcccaa  gtgctggga  tacaggcat  2160
agccactgt  cctggccaa  ataatgttt  cacagttcc  ctttgttgg  agaagtgtg  2220
gacctacaa  attcctggt  gatacagtt  aggtgagaa  ctgtttgat  atagaaaag  2280
ccccagact  agagggaag  ctctctggt  tacctgaga  ctatatgga  cttaaagga  2340
ggtgaataa  attaatgac  tgaattgaa  gagaatttg  agccaggat  ggtctccat  2400
ctgtgtggc  ccttgattg  aaaataata  ccatgcgtt  cttccactg  gtctttctt  2460
gattaaatc  ctcccagtt  tccgtgaag  gaaagacag  atttgcagt  ccgatgata  2520
agagtgact  ggagagaga  tcagaagtt  ggggtagcg  gggtaggat  gttgggacc  2580
gattgacta  cctgtaccc  tccttcttc  ccaatatgc  tgcgccatc  tcacattct  2640
aagttgaaa  ccatgatca  ccctttgag  tagattgac  ggctttaga  gcccacccc  2700
cacccaccg  aagctttga  tgggacacc  ttctgaatt  tttttctga  ttttttttt  2760
acatctctt  ctcattaga  atctgaaaa  tcattagag  tgttgagtc  tatcaaata  2820
aaagcatga  acatcatgg  caaaaaaaa  aaaaaaaaa  aaaa  2864



<210> 4033
<211> 377
<212> PRT
<213> Homo sapiens
<308> P28221
<400> 4033

Met Ser Pro Leu Asn Gln Ser Ala Glu Gly Leu Pro Gln Glu Ala Ser 
  1               5                  10                  15
Asn Arg Ser Leu Asn Ala Thr Glu Thr Ser Glu Ala Trp Asp Pro Arg 
             20                  25                  30
Thr Leu Gln Ala Leu Lys Ile Ser Leu Ala Val Val Leu Ser Val Ile 
         35                  40                  45
Thr Leu Ala Thr Val Leu Ser Asn Ala Phe Val Leu Thr Thr Ile Leu 
     50                  55                  60
Leu Thr Arg Lys Leu His Thr Pro Ala Asn Tyr Leu Ile Gly Ser Leu 
 65                  70                  75                  80
Ala Thr Thr Asp Leu Leu Val Ser Ile Leu Val Met Pro Ile Ser Ile 
                 85                  90                  95
Ala Tyr Thr Ile Thr His Thr Trp Asn Phe Gly Gln Ile Leu Cys Asp 
             100                105                110
Ile Trp Leu Ser Ser Asp Ile Thr Cys Cys Thr Ala Ser Ile Leu His 
         115                120                125
Leu Cys Val Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asp Ala Leu 
     130                135                140
Glu Tyr Ser Lys Arg Arg Thr Ala Gly His Ala Ala Thr Met Ile Ala 
 145                150                155                160
Ile Val Trp Ala Ile Ser Ile Cys Ile Ser Ile Pro Pro Leu Phe Trp 
                 165                170                175
Arg Gln Ala Lys Ala Gln Glu Glu Met Ser Asp Cys Leu Val Asn Thr 
             180                185                190
Ser Gln Ile Ser Tyr Thr Ile Tyr Ser Thr Cys Gly Ala Phe Tyr Ile 
         195                200                205
Pro Ser Val Leu Leu Ile Ile Leu Tyr Gly Arg Ile Tyr Arg Ala Ala 
     210                215                220
Arg Asn Arg Ile Leu Asn Pro Pro Ser Leu Tyr Gly Lys Arg Phe Thr 
 225                230                235                240
Thr Ala His Leu Ile Thr Gly Ser Ala Gly Ser Ser Leu Cys Ser Leu 
                 245                250                255
Asn Ser Ser Leu His Glu Gly His Ser His Ser Ala Gly Ser Pro Leu 
             260                265                270
Phe Phe Asn His Val Lys Ile Lys Leu Ala Asp Ser Ala Leu Glu Arg 
         275                280                285
Lys Arg Ile Ser Ala Ala Arg Glu Arg Lys Ala Thr Lys Ile Leu Gly 
     290                295                300
Ile Ile Leu Gly Ala Phe Ile Ile Cys Trp Leu Pro Phe Phe Val Val 
 305                310                315                320
Ser Leu Val Leu Pro Ile Cys Arg Asp Ser Cys Trp Ile His Pro Ala 
                 325                330                335
Leu Phe Asp Phe Phe Thr Trp Leu Gly Tyr Leu Asn Ser Leu Ile Asn 
             340                345                350
Pro Ile Ile Tyr Thr Val Phe Asn Glu Glu Phe Arg Gln Ala Phe Gln 
         355                360                365
Lys Ile Val Pro Phe Arg Lys Ala Ser 
     370                375



<210> 4034
<211> 4488
<212> DNA
<213> Rattus norvegicus
<308> M90518
<400> 4034

tgggccttt  attattatc  ggactttat  catgtccgg  gtgggttcc  atcagagaa  60
gtcaagctg  tccatctgt  ttccagcga  tggtcctcc  taaacatcc  cttcatggc  120
gcgggaagc  acggagccg  ctctttgag  cgcagactt  ggcgaagcg  ccacaacaa  180
aacggcggc  gcggcggca  cggcagcag  atcagcagc  cgggcaccg  ggccgccgc  240
cccagctcc  gcttcccgg  agcagccgc  gagcgccgc  cgctgctcc  agactccgg  300
cgcttggcc  ccagctcct  cccgccgcg  ccgggaccg  cggcggctc  gcgccccgc  360
tggtccgca  cgtcagcgc  gcccgccgc  gcccgggct  ccggcagtg  gagcagcta  420
gggctggcc  ccgcctccc  gagctcccc  ggagcagcc  acccctggt  gcggcgttc  480
cctcgccga  gcgcggttg  taggagtga  cggagccat  ctctcctcg  tgataagat  540
ccctaccag  ataggagcc  atctccctt  ccacagcag  acacagaaa  ctggccttc  600
gtactttgg  aaaaggatc  gagacctcc  ggagctctg  ccactggct  tcatctgtg  660
ctctggcct  tgtgggcca  tgagctcta  tcaaacatt  aagaggagg  ggggagatc  720
gtggaatgg  ccaccccgt  ggcctgctg  attactgaa  ctgcgctgt  cacacgtgc  780
cagatcatg  gacccaggg  ctgctaggg  taggagcgg  gcccagtat  catgggtct  840
taggccttt  cgaaatgtc  gggaaggga  gctgggcct  gtggtgggc  cggctgccc  900
tctgcctac  cctcagcct  tatgccccc  gggtgcctt  atccttggg  aagcccaag  960
gtcaccccc  catgaactc  atccgaatt  acggggaca  cacactggg  ggcctgttt  1020
ccgtccacg  ccgtggctc  gagggtaag  cctgcgggg  gctgaagaa  gagaaaggc  1080
tccaccgcc  ggaggccat  ctgtttgcc  tggaccgca  caacaatga  ccggaccta  1140
tgcccaaca  cacgttggg  gcccgcatt  tggacacct  ctcgaggga  acccacgcc  1200
tggagcagt  actgacctt  gtgcgggcg  tcatcgaga  ggacggcac  gaggtccgc  1260
gcggcagcg  gggcccgcc  atcatcacc  agcccgaac  agtggtggg  gtcattgga  1320
cttcgggga  ctccgtctc  atcatggtg  ccaacatcc  ccgcctctt  aagatccct  1380
agatcagct  tgcctccac  gcccctgac  tgagtgaca  cagccgcta  gacttcttc  1440
cccgggtgg  gccctcaga  acataccag  cccaggcca  ggtggatat  gtccgagcc  1500
tcaagtgga  ctatgtgtc  acactggcc  cagagggca  ctacggtga  agtggtgtg  1560
aggccttta  ccagaagtc  cgagagaac  gaggtgtgt  cattgccca  tcggtgaag  1620
ttccacggg  acccaagac  ggggagttc  acaagatca  caaacgcct  ctggaaaca  1680
ccaatgcca  gggtatcat  atctttgcc  acgaggatg  catcaggag  gtgttggag  1740
cagctcgca  ggccaacca  accggccac  tcttttgga  gggttctga  agctggggc  1800
ccaagagtg  ccctgtgct  cgccttgag  aggtggccg  gggcgcagt  accattctc  1860
ccaagagga  gtctgttcg  gggttcgac  gatacttct  cagccgcac  ctggacaac  1920
acaggcgca  catctggtt  gccgagttc  gggaggaca  cttccattg  aagttgagc  1980
gccacgcgc  caagaaggg  agccacatc  agaagtgca  caaccgaga  cgcatcggg  2040
aggactcgg  ctatgagca  gaggggaag  tgcagttcg  gattgacgc  gtgtacgcc  2100
tgggccacg  gctgcacgc  atgcaccgt  acctgtgtc  cggccgcgt  ggactctgc  2160
ctcgcatgg  ccccgtgga  ggcacccag  tgcttaagt  catcaggaa  gtcaacttc  2220
caggcattg  ggggaaccc  gtaaccttc  atgagaacg  agacgcacc  gggcgctac  2280
acatctacc  gtaccaact  cgcaatggc  cggccgagt  caaggtcat  ggctcgtgg  2340
cagaccacc  gcacctcag  atagagcgg  tgcagtggc  agggagtgg  cagcagctg  2400
cgcgctcca  ctgcagtct  ccctgccag  ccggggagc  aaagaagac  gtgaagggc  2460
tggcttgct  ctggcactg  gagccctgc  ccgggtacc  gtaccaagt  gaccgctac  2520
cctgtaaga  ctgccccta  gacatgcgg  ccacagaga  ccgcacgag  tgccagccc  2580
tccccatcg  caagttgga  tgggactcg  cgtgggccg  gctgcccct  ttcctggcc  2640
tggtgggca  cgccgccac  ctgttcgtg  tggtcacgt  tgtgcgcta  aacgatacc  2700
ccatcgtca  ggcctcggg  cgggagctg  gctacgtgc  gctggcggg  atctttctg  2760
gctacgcca  taccttcct  atgatcgca  agccggacc  ggggacctg  tcgctccgc  2820
gcatcttcc  agggctcgg  atgagcatc  gctacgcgg  cctgctgac  aagaccaac  2880
gcatttacc  catctttga  cagggcaaa  ggtcggtca  tgccccgcg  ttcatcagc  2940
cggcctcgc  gctggccat  accttcatc  tcatctccc  gcagctgct  ggcatctgc  3000
tgtggttcg  ggtggaccc  tcccactcg  tggtggact  ccaggacca  cggacactt  3060
acccccgct  tgccagggg  gtgctcaag  gcgacatct  ggacctgtc  ctcatctgc  3120
tgctgggct  cagcatgct  ctgatggtc  cgtgtactg  gtacgccat  aagacccga  3180
gcgtgcccg  gaccttcaa  gaggccaag  ccatcggct  caccatgta  accacctgc  3240
ttgtctggc  ggccttcat  cccatcttt  ttggcacct  acagtcagc  gacaagctg  3300
acatccaga  aaccacact  acggtctcc  tgagtctga  cgcttcagt  tccctgggg  3360
tgctctaca  gcccaaagt  tacatcatc  tcttccacc  ggagcagaa  gtgcccaag  3420
gcaagcgca  tctcaaagc  gtggtcacc  ccgccacca  gtccaacaa  ttcacacag  3480
agggcaact  caggcccaa  ggggaagcc  aatcagagc  gtgtgagaa  ctggagacc  3540
cagcgctgg  taccaaaca  acctacgtc  cctacacca  ccatgccat  tagccgggc  3600
gcggagcca  gcaggctaa  gagccacaa  ctctgagga  ggcacattg  gccagggcc  3660
ttcccgagg  ccctgccga  gtctgcccg  ctcccgggc  tccacgaat  tggcttggt  3720
ctgaggaca  tagagaccc  ggccatcac  gctgggcaa  ccgtggtgg  caaccagag  3780
aggccgagt  gctggggca  ttccaggtt  tgccacaca  aggtcttcc  tctggacca  3840
tgttgggcc  agccccaaa  cacaggggc  cggtctcca  agcccagcc  tggcttcct  3900
tccttcctc  tgcctccgt  tgtcctgtg  gtgaccccg  ttggtccct  ccccgtctt  3960
acgtttctc  tccgtcttt  ctctgcatg  gttgtctgt  tgggccctc  gcttccata  4020
ttttccatt  tgctcctgg  cttcccctg  catctgccc  gccccctgc  cctcctccc  4080
gagctgccc  atccccgcc  tcattttct  ttctgttcc  cctcgatct  atttcctac  4140
agccttccc  ctacttggc  tcatccacc  actctttca  cacgttgca  aagagaaaa  4200
aaaaggggg  ggggaatca  cccctacaa  aaagcccaa  caaaaacta  tcttgagtg  4260
gtttcgaag  gctgcgtcc  cctggtggc  tgtgtgtcc  tgtggcctg  agcctgctc  4320
cccgcccta  ccgtctgcc  tgtgtcctg  ccgcccgcc  gcccgcctt  cccttcctg  4380
taacgacac  gagttcagt  cctgggtgt  tggtgatgg  ctctgatgt  tagcatgtc  4440
gtttttata  cgagaacat  tctaataaa  ataaacaca  ggttttgc  4488



<210> 4035
<211> 912
<212> PRT
<213> Rattus norvegicus
<308> P31423
<400> 4035

Met Ser Gly Lys Gly Gly Trp Ala Trp Trp Trp Ala Arg Leu Pro Leu 
  1               5                  10                  15
Cys Leu Leu Leu Ser Leu Tyr Ala Pro Trp Val Pro Ser Ser Leu Gly 
             20                  25                  30
Lys Pro Lys Gly His Pro His Met Asn Ser Ile Arg Ile Asp Gly Asp 
         35                  40                  45
Ile Thr Leu Gly Gly Leu Phe Pro Val His Gly Arg Gly Ser Glu Gly 
     50                  55                  60
Lys Ala Cys Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu 
 65                  70                  75                  80
Ala Met Leu Phe Ala Leu Asp Arg Ile Asn Asn Asp Pro Asp Leu Leu 
                 85                  90                  95
Pro Asn Ile Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
             100                105                110
Thr His Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu 
         115                120                125
Lys Asp Gly Thr Glu Val Arg Cys Gly Ser Gly Gly Pro Pro Ile Ile 
     130                135                140
Thr Lys Pro Glu Arg Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
 145                150                155                160
Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln 
                 165                170                175
Ile Ser Tyr Ala Ser Thr Ala Pro Asp Leu Ser Asp Asn Ser Arg Tyr 
             180                185                190
Asp Phe Phe Ser Arg Val Val Pro Ser Asp Thr Tyr Gln Ala Gln Ala 
         195                200                205
Met Val Asp Ile Val Arg Ala Leu Lys Trp Asn Tyr Val Ser Thr Leu 
     210                215                220
Ala Ser Glu Gly Ser Tyr Gly Glu Ser Gly Val Glu Ala Phe Ile Gln 
 225                230                235                240
Lys Ser Arg Glu Asn Gly Gly Val Cys Ile Ala Gln Ser Val Lys Ile 
                 245                250                255
Pro Arg Glu Pro Lys Thr Gly Glu Phe Asp Lys Ile Ile Lys Arg Leu 
             260                265                270
Leu Glu Thr Ser Asn Ala Arg Gly Ile Ile Ile Phe Ala Asn Glu Asp 
         275                280                285
Asp Ile Arg Arg Val Leu Glu Ala Ala Arg Arg Ala Asn Gln Thr Gly 
     290                295                300
His Phe Phe Trp Met Gly Ser Asp Ser Trp Gly Ser Lys Ser Ala Pro 
 305                310                315                320
Val Leu Arg Leu Glu Glu Val Ala Glu Gly Ala Val Thr Ile Leu Pro 
                 325                330                335
Lys Arg Met Ser Val Arg Gly Phe Asp Arg Tyr Phe Ser Ser Arg Thr 
             340                345                350
Leu Asp Asn Asn Arg Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Asp 
         355                360                365
Asn Phe His Cys Lys Leu Ser Arg His Ala Leu Lys Lys Gly Ser His 
     370                375                380
Ile Lys Lys Cys Thr Asn Arg Glu Arg Ile Gly Gln Asp Ser Ala Tyr 
 385                390                395                400
Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ala Met 
                 405                410                415
Gly His Ala Leu His Ala Met His Arg Asp Leu Cys Pro Gly Arg Val 
             420                425                430
Gly Leu Cys Pro Arg Met Asp Pro Val Asp Gly Thr Gln Leu Leu Lys 
         435                440                445
Tyr Ile Arg Asn Val Asn Phe Ser Gly Ile Ala Gly Asn Pro Val Thr 
     450                455                460
Phe Asn Glu Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Tyr Gln Tyr 
 465                470                475                480
Gln Leu Arg Asn Gly Ser Ala Glu Tyr Lys Val Ile Gly Ser Trp Thr 
                 485                490                495
Asp His Leu His Leu Arg Ile Glu Arg Met Gln Trp Pro Gly Ser Gly 
             500                505                510
Gln Gln Leu Pro Arg Ser Ile Cys Ser Leu Pro Cys Gln Pro Gly Glu 
         515                520                525
Arg Lys Lys Thr Val Lys Gly Met Ala Cys Cys Trp His Cys Glu Pro 
     530                535                540
Cys Thr Gly Tyr Gln Tyr Gln Val Asp Arg Tyr Thr Cys Lys Thr Cys 
 545                550                555                560
Pro Tyr Asp Met Arg Pro Thr Glu Asn Arg Thr Ser Cys Gln Pro Ile 
                 565                570                575
Pro Ile Val Lys Leu Glu Trp Asp Ser Pro Trp Ala Val Leu Pro Leu 
             580                585                590
Phe Leu Ala Val Val Gly Ile Ala Ala Thr Leu Phe Val Val Val Thr 
         595                600                605
Phe Val Arg Tyr Asn Asp Thr Pro Ile Val Lys Ala Ser Gly Arg Glu 
     610                615                620
Leu Ser Tyr Val Leu Leu Ala Gly Ile Phe Leu Cys Tyr Ala Thr Thr 
 625                630                635                640
Phe Leu Met Ile Ala Glu Pro Asp Leu Gly Thr Cys Ser Leu Arg Arg 
                 645                650                655
Ile Phe Leu Gly Leu Gly Met Ser Ile Ser Tyr Ala Ala Leu Leu Thr 
             660                665                670
Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val 
         675                680                685
Ser Ala Pro Arg Phe Ile Ser Pro Ala Ser Gln Leu Ala Ile Thr Phe 
     690                695                700
Ile Leu Ile Ser Leu Gln Leu Leu Gly Ile Cys Val Trp Phe Val Val 
 705                710                715                720
Asp Pro Ser His Ser Val Val Asp Phe Gln Asp Gln Arg Thr Leu Asp 
                 725                730                735
Pro Arg Phe Ala Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser 
             740                745                750
Leu Ile Cys Leu Leu Gly Tyr Ser Met Leu Leu Met Val Thr Cys Thr 
         755                760                765
Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala 
     770                775                780
Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val Trp Leu Ala 
 785                790                795                800
Phe Ile Pro Ile Phe Phe Gly Thr Ser Gln Ser Ala Asp Lys Leu Tyr 
                 805                810                815
Ile Gln Thr Thr Thr Leu Thr Val Ser Val Ser Leu Ser Ala Ser Val 
             820                825                830
Ser Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile Leu Phe His 
         835                840                845
Pro Glu Gln Asn Val Pro Lys Arg Lys Arg Ser Leu Lys Ala Val Val 
     850                855                860
Thr Ala Ala Thr Met Ser Asn Lys Phe Thr Gln Lys Gly Asn Phe Arg 
 865                870                875                880
Pro Asn Gly Glu Ala Lys Ser Glu Leu Cys Glu Asn Leu Glu Thr Pro 
                 885                890                895
Ala Leu Ala Thr Lys Gln Thr Tyr Val Thr Tyr Thr Asn His Ala Ile 
             900                905                910



<210> 4036
<211> 3431
<212> DNA
<213> Homo sapiens
<308> U92457
<400> 4036

tcatgggtc  ctagggatt  ccgaaatgc  tgggaagag  ggcttgggc  ggtggtggg  60
ccggctgcc  ctttgcctg  tcctcagcc  ttacggccc  tggatgcct  cctccctgg  120
aaagcccaa  ggccaccct  acatgaatt  catccgcat  gatggggac  tcacactgg  180
aggcctgtt  ccggtgcat  gccggggct  agagggcaa  ccctgtgga  aacttaaga  240
ggaaaaggg  atccaccgg  tggaggcca  gctgttcgc  ctggatcgc  tcaacaacg  300
cccggacct  ctgcctaac  tcacgctgg  cgcccgcat  ctggacacc  gctccaggg  360
cacccatgc  ctcgagcag  cgctgacct  tgtgcaggc  ctcatcgag  aggatggca  420
agaggtccg  tgtggcagt  gcggcccac  catcatcac  aagcctgaa  gtgtggtgg  480
tgtcatcgg  gcttcaggg  gctcggtct  catcatggt  gccaacatc  ttcgcctct  540
caagatacc  cagatcagc  acgcctcca  agcgccaga  ctgagtgac  acagccgct  600
cgacttctt  tcccgcgtg  tgccctcgg  cacgtacca  gcccaggcc  tggtggaca  660
cgtccgcgc  ctcaagtgg  actatgtgt  cacagtggc  tcggagggc  gctatggtg  720
gagcggtgt  gaggccttc  tccagaagt  ccgtgagga  gggggcgtg  gcatcgccc  780
gtcggtgaa  ataccacgg  agcccaagg  aggcgagtt  gacaagatc  tccgccgcc  840
cctggagac  tcgaacgcc  gggcagtca  catctttgc  aacgaggat  acatcaggc  900
tgtgctgga  gcagcacga  gggccaacc  gacaggcca  ttcttctgg  tgggctctg  960
cagctgggg  tccaagatt  cacctgtgc  gcacctgga  gaggtggct  agggtgctg  1020
cacgatcct  cccaagagg  tgtccgtac  aggcttcga  cgctacttc  ccagccgca  1080
gctggacaa  aaccggcgc  acatctggt  tgccgagtt  tgggaggac  acttccact  1140
caagctgag  cgccacgcc  tcaagaagg  cagccacgt  aagaagtgc  ccaaccgtg  1200
gcgaattgg  caggattca  cttatgagc  ggaggggaa  gtgcagttt  tgatcgatg  1260
cgtgtacgc  atgggccac  cgctgcacg  catgcaccg  gacctgtgt  ccggccgcg  1320
ggggctctg  ccgcgcatg  accctgtag  tggcaccca  ctgcttaag  acatccgaa  1380
cgtcaactt  tcaggcatc  cagggaacc  tgtgacctt  aatgagaat  gagatgcgc  1440
tgggcgcta  gacatctac  aataccagc  gcgcaacga  tctgccgag  acaaggtca  1500
tggctcctg  actgaccac  tgcacctta  aatagagcg  atgcactgg  cggggagcg  1560
gcagcagct  ccccgctcc  tctgcagcc  gccctgcca  ccgggtgag  ggaagaaga  1620
agtgaaggg  atgccttgc  gctggcact  cgagccttg  acagggtac  agtaccagg  1680
ggaccgcta  acctgtaag  cgtgtccct  tgacatgcg  cccacagag  accgcacgg  1740
ctgccggcc  atccccatc  tcaagcttg  gtggggctc  ccctgggcc  tgctgcccc  1800
cttcctggc  gtggtgggc  tcgctgcca  gttgttcgt  gtgatcacc  ttgtgcgct  1860
caacgacac  cccatcgtc  aggcctcgg  ccgtgaact  agctacgtg  tgctggcag  1920
catcttcct  tgctatgcc  ccaccttcc  catgatcgc  gagcccgac  ttggcacct  1980
ctcgctgcg  cgaatcttc  tgggactag  gatgagcat  agctatgca  ccctgctca  2040
caagaccaa  cgcatctac  gcatcttcg  gcagggcaa  cgctcggtc  gtgccccac  2100
cttcatcag  cccgcctca  agctggcca  caccttcag  ctcatctcg  tgcagctgc  2160
gggcatctg  gtgtggttt  tggtggacc  ctcccactc  gtggtggac  tccaggacc  2220
gcggacact  gacccccgc  tcgccaggg  tgtgctcaa  tgtgacatc  cggacctgt  2280
gctcatctg  ctgctgggc  acagcatgc  gctcatggt  acgtgcacc  tgtatgcca  2340
caagacacg  ggcgtgccc  agaccttca  tgaggccaa  cccattggc  tcaccatgt  2400
caccacttg  atcgtctgg  tggccttca  ccccatctt  tttggcacc  cgcagtcgg  2460
cgacaagct  tacatccag  cgacgacgc  gacggtctc  gtgagtctg  gcgcctcgg  2520
gtccctggg  atgctctac  tgcccaaag  ctacatcat  ctcttccac  cggagcaga  2580
cgtgcccaa  cgcaagcgc  gcctcaaag  cgtcgttac  gcggccacc  tgtccaaca  2640
gttcacgca  aagggcaac  tccggccca  cggagaggc  aagtctgag  tctgcgaga  2700
ccttgaggc  ccagcgctg  ccaccaaac  gacttacgt  acttacacc  accatgcaa  2760
ctagcgagt  catggagct  agcagcagg  ggaggagcc  tgaccctgt  gaaggtgcg  2820
cgggccagg  ccacaccca  gggcccagc  gtcttgcct  cccgtgggc  cccacggac  2880
tggcttggt  ctgagatag  agagccccc  gccatcact  ctggcagcc  gggcaaacc  2940
ggtgagcaa  aggaggacg  ggggccggg  cggtgccag  ctaccacaa  aacctgcgt  3000
ttggaccat  gcccctccc  gccccaaac  acaggggct  aggtcgtgt  ggccccagt  3060
ctagatctc  ccctccctt  gtctctgtc  gtgctgttg  cgacccctc  gtctgtctc  3120
agccctgtc  ttctgttct  ttatctctt  gtttcacct  ttccctctc  ggcgtcccc  3180
gctgcttgt  ctcttggcc  tttctgtgt  tcctttctg  ctcttgcct  cgcctctct  3240
tctcatcct  tttgtcctc  gctcctcct  ctttcttgg  tcccaccag  gtcactttt  3300
tgccgtttt  tttcctgtt  tcctctgct  cattctcgt  cagccattg  tcccctctc  3360
ctgccaccc  tccccagtt  accaaacct  acatgttgc  aaagaaaaa  aaaaaaagg  3420
attcctgca  c  3431



<210> 4037
<211> 912
<212> PRT
<213> Homo sapiens
<308> Q14833
<400> 4037

Met Pro Gly Lys Arg Gly Leu Gly Trp Trp Trp Ala Arg Leu Pro Leu 
  1               5                  10                  15
Cys Leu Leu Leu Ser Leu Tyr Gly Pro Trp Met Pro Ser Ser Leu Gly 
             20                  25                  30
Lys Pro Lys Gly His Pro His Met Asn Ser Ile Arg Ile Asp Gly Asp 
         35                  40                  45
Ile Thr Leu Gly Gly Leu Phe Pro Val His Gly Arg Gly Ser Glu Gly 
     50                  55                  60
Lys Pro Cys Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu 
 65                  70                  75                  80
Ala Met Leu Phe Ala Leu Asp Arg Ile Asn Asn Asp Pro Asp Leu Leu 
                 85                  90                  95
Pro Asn Ile Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
             100                105                110
Thr His Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu 
         115                120                125
Lys Asp Gly Thr Glu Val Arg Cys Gly Ser Gly Gly Pro Pro Ile Ile 
     130                135                140
Thr Lys Pro Glu Arg Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
 145                150                155                160
Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln 
                 165                170                175
Ile Ser Tyr Ala Ser Thr Ala Pro Asp Leu Ser Asp Asn Ser Arg Tyr 
             180                185                190
Asp Phe Phe Ser Arg Val Val Pro Ser Asp Thr Tyr Gln Ala Gln Ala 
         195                200                205
Met Val Asp Ile Val Arg Ala Leu Lys Trp Asn Tyr Val Ser Thr Val 
     210                215                220
Ala Ser Glu Gly Ser Tyr Gly Glu Ser Gly Val Glu Ala Phe Ile Gln 
 225                230                235                240
Lys Ser Arg Glu Asp Gly Gly Val Cys Ile Ala Gln Ser Val Lys Ile 
                 245                250                255
Pro Arg Glu Pro Lys Ala Gly Glu Phe Asp Lys Ile Ile Arg Arg Leu 
             260                265                270
Leu Glu Thr Ser Asn Ala Arg Ala Val Ile Ile Phe Ala Asn Glu Asp 
         275                280                285
Asp Ile Arg Arg Val Leu Glu Ala Ala Arg Arg Ala Asn Gln Thr Gly 
     290                295                300
His Phe Phe Trp Met Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro 
 305                310                315                320
Val Leu His Leu Glu Glu Val Ala Glu Gly Ala Val Thr Ile Leu Pro 
                 325                330                335
Lys Arg Met Ser Val Arg Gly Phe Asp Arg Tyr Phe Ser Ser Arg Thr 
             340                345                350
Leu Asp Asn Asn Arg Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Asp 
         355                360                365
Asn Phe His Cys Lys Leu Ser Arg His Ala Leu Lys Lys Gly Ser His 
     370                375                380
Val Lys Lys Cys Thr Asn Arg Glu Arg Ile Gly Gln Asp Ser Ala Tyr 
 385                390                395                400
Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ala Met 
                 405                410                415
Gly His Ala Leu His Ala Met His Arg Asp Leu Cys Pro Gly Arg Val 
             420                425                430
Gly Leu Cys Pro Arg Met Asp Pro Val Asp Gly Thr Gln Leu Leu Lys 
         435                440                445
Tyr Ile Arg Asn Val Asn Phe Ser Gly Ile Ala Gly Asn Pro Val Thr 
     450                455                460
Phe Asn Glu Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Tyr Gln Tyr 
 465                470                475                480
Gln Leu Arg Asn Asp Ser Ala Glu Tyr Lys Val Ile Gly Ser Trp Thr 
                 485                490                495
Asp His Leu His Leu Arg Ile Glu Arg Met His Trp Pro Gly Ser Gly 
             500                505                510
Gln Gln Leu Pro Arg Ser Ile Cys Ser Leu Pro Cys Gln Pro Gly Glu 
         515                520                525
Arg Lys Lys Thr Val Lys Gly Met Pro Cys Cys Trp His Cys Glu Pro 
     530                535                540
Cys Thr Gly Tyr Gln Tyr Gln Val Asp Arg Tyr Thr Cys Lys Thr Cys 
 545                550                555                560
Pro Tyr Asp Met Arg Pro Thr Glu Asn Arg Thr Gly Cys Arg Pro Ile 
                 565                570                575
Pro Ile Ile Lys Leu Glu Trp Gly Ser Pro Trp Ala Val Leu Pro Leu 
             580                585                590
Phe Leu Ala Val Val Gly Ile Ala Ala Thr Leu Phe Val Val Ile Thr 
         595                600                605
Phe Val Arg Tyr Asn Asp Thr Pro Ile Val Lys Ala Ser Gly Arg Glu 
     610                615                620
Leu Ser Tyr Val Leu Leu Ala Gly Ile Phe Leu Cys Tyr Ala Thr Thr 
 625                630                635                640
Phe Leu Met Ile Ala Glu Pro Asp Leu Gly Thr Cys Ser Leu Arg Arg 
                 645                650                655
Ile Phe Leu Gly Leu Gly Met Ser Ile Ser Tyr Ala Ala Leu Leu Thr 
             660                665                670
Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val 
         675                680                685
Ser Ala Pro Arg Phe Ile Ser Pro Ala Ser Gln Leu Ala Ile Thr Phe 
     690                695                700
Ser Leu Ile Ser Leu Gln Leu Leu Gly Ile Cys Val Trp Phe Val Val 
 705                710                715                720
Asp Pro Ser His Ser Val Val Asp Phe Gln Asp Gln Arg Thr Leu Asp 
                 725                730                735
Pro Arg Phe Ala Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser 
             740                745                750
Leu Ile Cys Leu Leu Gly Tyr Ser Met Leu Leu Met Val Thr Cys Thr 
         755                760                765
Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala 
     770                775                780
Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val Trp Leu Ala 
 785                790                795                800
Phe Ile Pro Ile Phe Phe Gly Thr Ser Gln Ser Ala Asp Lys Leu Tyr 
                 805                810                815
Ile Gln Thr Thr Thr Leu Thr Val Ser Val Ser Leu Ser Ala Ser Val 
             820                825                830
Ser Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile Leu Phe His 
         835                840                845
Pro Glu Gln Asn Val Pro Lys Arg Lys Arg Ser Leu Lys Ala Val Val 
     850                855                860
Thr Ala Ala Thr Met Ser Asn Lys Phe Thr Gln Lys Gly Asn Phe Arg 
 865                870                875                880
Pro Asn Gly Glu Ala Lys Ser Glu Leu Cys Glu Asn Leu Glu Ala Pro 
                 885                890                895
Ala Leu Ala Thr Lys Gln Thr Tyr Val Thr Tyr Thr Asn His Ala Ile 
             900                905                910



<210> 4038
<211> 4488
<212> DNA
<213> Rattus norvegicus
<308> M90518
<400> 4038

tgggccttt  attattatc  ggactttat  catgtccgg  gtgggttcc  atcagagaa  60
gtcaagctg  tccatctgt  ttccagcga  tggtcctcc  taaacatcc  cttcatggc  120
gcgggaagc  acggagccg  ctctttgag  cgcagactt  ggcgaagcg  ccacaacaa  180
aacggcggc  gcggcggca  cggcagcag  atcagcagc  cgggcaccg  ggccgccgc  240
cccagctcc  gcttcccgg  agcagccgc  gagcgccgc  cgctgctcc  agactccgg  300
cgcttggcc  ccagctcct  cccgccgcg  ccgggaccg  cggcggctc  gcgccccgc  360
tggtccgca  cgtcagcgc  gcccgccgc  gcccgggct  ccggcagtg  gagcagcta  420
gggctggcc  ccgcctccc  gagctcccc  ggagcagcc  acccctggt  gcggcgttc  480
cctcgccga  gcgcggttg  taggagtga  cggagccat  ctctcctcg  tgataagat  540
ccctaccag  ataggagcc  atctccctt  ccacagcag  acacagaaa  ctggccttc  600
gtactttgg  aaaaggatc  gagacctcc  ggagctctg  ccactggct  tcatctgtg  660
ctctggcct  tgtgggcca  tgagctcta  tcaaacatt  aagaggagg  ggggagatc  720
gtggaatgg  ccaccccgt  ggcctgctg  attactgaa  ctgcgctgt  cacacgtgc  780
cagatcatg  gacccaggg  ctgctaggg  taggagcgg  gcccagtat  catgggtct  840
taggccttt  cgaaatgtc  gggaaggga  gctgggcct  gtggtgggc  cggctgccc  900
tctgcctac  cctcagcct  tatgccccc  gggtgcctt  atccttggg  aagcccaag  960
gtcaccccc  catgaactc  atccgaatt  acggggaca  cacactggg  ggcctgttt  1020
ccgtccacg  ccgtggctc  gagggtaag  cctgcgggg  gctgaagaa  gagaaaggc  1080
tccaccgcc  ggaggccat  ctgtttgcc  tggaccgca  caacaatga  ccggaccta  1140
tgcccaaca  cacgttggg  gcccgcatt  tggacacct  ctcgaggga  acccacgcc  1200
tggagcagt  actgacctt  gtgcgggcg  tcatcgaga  ggacggcac  gaggtccgc  1260
gcggcagcg  gggcccgcc  atcatcacc  agcccgaac  agtggtggg  gtcattgga  1320
cttcgggga  ctccgtctc  atcatggtg  ccaacatcc  ccgcctctt  aagatccct  1380
agatcagct  tgcctccac  gcccctgac  tgagtgaca  cagccgcta  gacttcttc  1440
cccgggtgg  gccctcaga  acataccag  cccaggcca  ggtggatat  gtccgagcc  1500
tcaagtgga  ctatgtgtc  acactggcc  cagagggca  ctacggtga  agtggtgtg  1560
aggccttta  ccagaagtc  cgagagaac  gaggtgtgt  cattgccca  tcggtgaag  1620
ttccacggg  acccaagac  ggggagttc  acaagatca  caaacgcct  ctggaaaca  1680
ccaatgcca  gggtatcat  atctttgcc  acgaggatg  catcaggag  gtgttggag  1740
cagctcgca  ggccaacca  accggccac  tcttttgga  gggttctga  agctggggc  1800
ccaagagtg  ccctgtgct  cgccttgag  aggtggccg  gggcgcagt  accattctc  1860
ccaagagga  gtctgttcg  gggttcgac  gatacttct  cagccgcac  ctggacaac  1920
acaggcgca  catctggtt  gccgagttc  gggaggaca  cttccattg  aagttgagc  1980
gccacgcgc  caagaaggg  agccacatc  agaagtgca  caaccgaga  cgcatcggg  2040
aggactcgg  ctatgagca  gaggggaag  tgcagttcg  gattgacgc  gtgtacgcc  2100
tgggccacg  gctgcacgc  atgcaccgt  acctgtgtc  cggccgcgt  ggactctgc  2160
ctcgcatgg  ccccgtgga  ggcacccag  tgcttaagt  catcaggaa  gtcaacttc  2220
caggcattg  ggggaaccc  gtaaccttc  atgagaacg  agacgcacc  gggcgctac  2280
acatctacc  gtaccaact  cgcaatggc  cggccgagt  caaggtcat  ggctcgtgg  2340
cagaccacc  gcacctcag  atagagcgg  tgcagtggc  agggagtgg  cagcagctg  2400
cgcgctcca  ctgcagtct  ccctgccag  ccggggagc  aaagaagac  gtgaagggc  2460
tggcttgct  ctggcactg  gagccctgc  ccgggtacc  gtaccaagt  gaccgctac  2520
cctgtaaga  ctgccccta  gacatgcgg  ccacagaga  ccgcacgag  tgccagccc  2580
tccccatcg  caagttgga  tgggactcg  cgtgggccg  gctgcccct  ttcctggcc  2640
tggtgggca  cgccgccac  ctgttcgtg  tggtcacgt  tgtgcgcta  aacgatacc  2700
ccatcgtca  ggcctcggg  cgggagctg  gctacgtgc  gctggcggg  atctttctg  2760
gctacgcca  taccttcct  atgatcgca  agccggacc  ggggacctg  tcgctccgc  2820
gcatcttcc  agggctcgg  atgagcatc  gctacgcgg  cctgctgac  aagaccaac  2880
gcatttacc  catctttga  cagggcaaa  ggtcggtca  tgccccgcg  ttcatcagc  2940
cggcctcgc  gctggccat  accttcatc  tcatctccc  gcagctgct  ggcatctgc  3000
tgtggttcg  ggtggaccc  tcccactcg  tggtggact  ccaggacca  cggacactt  3060
acccccgct  tgccagggg  gtgctcaag  gcgacatct  ggacctgtc  ctcatctgc  3120
tgctgggct  cagcatgct  ctgatggtc  cgtgtactg  gtacgccat  aagacccga  3180
gcgtgcccg  gaccttcaa  gaggccaag  ccatcggct  caccatgta  accacctgc  3240
ttgtctggc  ggccttcat  cccatcttt  ttggcacct  acagtcagc  gacaagctg  3300
acatccaga  aaccacact  acggtctcc  tgagtctga  cgcttcagt  tccctgggg  3360
tgctctaca  gcccaaagt  tacatcatc  tcttccacc  ggagcagaa  gtgcccaag  3420
gcaagcgca  tctcaaagc  gtggtcacc  ccgccacca  gtccaacaa  ttcacacag  3480
agggcaact  caggcccaa  ggggaagcc  aatcagagc  gtgtgagaa  ctggagacc  3540
cagcgctgg  taccaaaca  acctacgtc  cctacacca  ccatgccat  tagccgggc  3600
gcggagcca  gcaggctaa  gagccacaa  ctctgagga  ggcacattg  gccagggcc  3660
ttcccgagg  ccctgccga  gtctgcccg  ctcccgggc  tccacgaat  tggcttggt  3720
ctgaggaca  tagagaccc  ggccatcac  gctgggcaa  ccgtggtgg  caaccagag  3780
aggccgagt  gctggggca  ttccaggtt  tgccacaca  aggtcttcc  tctggacca  3840
tgttgggcc  agccccaaa  cacaggggc  cggtctcca  agcccagcc  tggcttcct  3900
tccttcctc  tgcctccgt  tgtcctgtg  gtgaccccg  ttggtccct  ccccgtctt  3960
acgtttctc  tccgtcttt  ctctgcatg  gttgtctgt  tgggccctc  gcttccata  4020
ttttccatt  tgctcctgg  cttcccctg  catctgccc  gccccctgc  cctcctccc  4080
gagctgccc  atccccgcc  tcattttct  ttctgttcc  cctcgatct  atttcctac  4140
agccttccc  ctacttggc  tcatccacc  actctttca  cacgttgca  aagagaaaa  4200
aaaaggggg  ggggaatca  cccctacaa  aaagcccaa  caaaaacta  tcttgagtg  4260
gtttcgaag  gctgcgtcc  cctggtggc  tgtgtgtcc  tgtggcctg  agcctgctc  4320
cccgcccta  ccgtctgcc  tgtgtcctg  ccgcccgcc  gcccgcctt  cccttcctg  4380
taacgacac  gagttcagt  cctgggtgt  tggtgatgg  ctctgatgt  tagcatgtc  4440
gtttttata  cgagaacat  tctaataaa  ataaacaca  ggttttgc  4488



<210> 4039
<211> 912
<212> PRT
<213> Rattus norvegicus
<308> P31423
<400> 4039

Met Ser Gly Lys Gly Gly Trp Ala Trp Trp Trp Ala Arg Leu Pro Leu 
  1               5                  10                  15
Cys Leu Leu Leu Ser Leu Tyr Ala Pro Trp Val Pro Ser Ser Leu Gly 
             20                  25                  30
Lys Pro Lys Gly His Pro His Met Asn Ser Ile Arg Ile Asp Gly Asp 
         35                  40                  45
Ile Thr Leu Gly Gly Leu Phe Pro Val His Gly Arg Gly Ser Glu Gly 
     50                  55                  60
Lys Ala Cys Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu 
 65                  70                  75                  80
Ala Met Leu Phe Ala Leu Asp Arg Ile Asn Asn Asp Pro Asp Leu Leu 
                 85                  90                  95
Pro Asn Ile Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
             100                105                110
Thr His Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu 
         115                120                125
Lys Asp Gly Thr Glu Val Arg Cys Gly Ser Gly Gly Pro Pro Ile Ile 
     130                135                140
Thr Lys Pro Glu Arg Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
 145                150                155                160
Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln 
                 165                170                175
Ile Ser Tyr Ala Ser Thr Ala Pro Asp Leu Ser Asp Asn Ser Arg Tyr 
             180                185                190
Asp Phe Phe Ser Arg Val Val Pro Ser Asp Thr Tyr Gln Ala Gln Ala 
         195                200                205
Met Val Asp Ile Val Arg Ala Leu Lys Trp Asn Tyr Val Ser Thr Leu 
     210                215                220
Ala Ser Glu Gly Ser Tyr Gly Glu Ser Gly Val Glu Ala Phe Ile Gln 
 225                230                235                240
Lys Ser Arg Glu Asn Gly Gly Val Cys Ile Ala Gln Ser Val Lys Ile 
                 245                250                255
Pro Arg Glu Pro Lys Thr Gly Glu Phe Asp Lys Ile Ile Lys Arg Leu 
             260                265                270
Leu Glu Thr Ser Asn Ala Arg Gly Ile Ile Ile Phe Ala Asn Glu Asp 
         275                280                285
Asp Ile Arg Arg Val Leu Glu Ala Ala Arg Arg Ala Asn Gln Thr Gly 
     290                295                300
His Phe Phe Trp Met Gly Ser Asp Ser Trp Gly Ser Lys Ser Ala Pro 
 305                310                315                320
Val Leu Arg Leu Glu Glu Val Ala Glu Gly Ala Val Thr Ile Leu Pro 
                 325                330                335
Lys Arg Met Ser Val Arg Gly Phe Asp Arg Tyr Phe Ser Ser Arg Thr 
             340                345                350
Leu Asp Asn Asn Arg Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Asp 
         355                360                365
Asn Phe His Cys Lys Leu Ser Arg His Ala Leu Lys Lys Gly Ser His 
     370                375                380
Ile Lys Lys Cys Thr Asn Arg Glu Arg Ile Gly Gln Asp Ser Ala Tyr 
 385                390                395                400
Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ala Met 
                 405                410                415
Gly His Ala Leu His Ala Met His Arg Asp Leu Cys Pro Gly Arg Val 
             420                425                430
Gly Leu Cys Pro Arg Met Asp Pro Val Asp Gly Thr Gln Leu Leu Lys 
         435                440                445
Tyr Ile Arg Asn Val Asn Phe Ser Gly Ile Ala Gly Asn Pro Val Thr 
     450                455                460
Phe Asn Glu Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Tyr Gln Tyr 
 465                470                475                480
Gln Leu Arg Asn Gly Ser Ala Glu Tyr Lys Val Ile Gly Ser Trp Thr 
                 485                490                495
Asp His Leu His Leu Arg Ile Glu Arg Met Gln Trp Pro Gly Ser Gly 
             500                505                510
Gln Gln Leu Pro Arg Ser Ile Cys Ser Leu Pro Cys Gln Pro Gly Glu 
         515                520                525
Arg Lys Lys Thr Val Lys Gly Met Ala Cys Cys Trp His Cys Glu Pro 
     530                535                540
Cys Thr Gly Tyr Gln Tyr Gln Val Asp Arg Tyr Thr Cys Lys Thr Cys 
 545                550                555                560
Pro Tyr Asp Met Arg Pro Thr Glu Asn Arg Thr Ser Cys Gln Pro Ile 
                 565                570                575
Pro Ile Val Lys Leu Glu Trp Asp Ser Pro Trp Ala Val Leu Pro Leu 
             580                585                590
Phe Leu Ala Val Val Gly Ile Ala Ala Thr Leu Phe Val Val Val Thr 
         595                600                605
Phe Val Arg Tyr Asn Asp Thr Pro Ile Val Lys Ala Ser Gly Arg Glu 
     610                615                620
Leu Ser Tyr Val Leu Leu Ala Gly Ile Phe Leu Cys Tyr Ala Thr Thr 
 625                630                635                640
Phe Leu Met Ile Ala Glu Pro Asp Leu Gly Thr Cys Ser Leu Arg Arg 
                 645                650                655
Ile Phe Leu Gly Leu Gly Met Ser Ile Ser Tyr Ala Ala Leu Leu Thr 
             660                665                670
Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val 
         675                680                685
Ser Ala Pro Arg Phe Ile Ser Pro Ala Ser Gln Leu Ala Ile Thr Phe 
     690                695                700
Ile Leu Ile Ser Leu Gln Leu Leu Gly Ile Cys Val Trp Phe Val Val 
 705                710                715                720
Asp Pro Ser His Ser Val Val Asp Phe Gln Asp Gln Arg Thr Leu Asp 
                 725                730                735
Pro Arg Phe Ala Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser 
             740                745                750
Leu Ile Cys Leu Leu Gly Tyr Ser Met Leu Leu Met Val Thr Cys Thr 
         755                760                765
Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala 
     770                775                780
Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val Trp Leu Ala 
 785                790                795                800
Phe Ile Pro Ile Phe Phe Gly Thr Ser Gln Ser Ala Asp Lys Leu Tyr 
                 805                810                815
Ile Gln Thr Thr Thr Leu Thr Val Ser Val Ser Leu Ser Ala Ser Val 
             820                825                830
Ser Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile Leu Phe His 
         835                840                845
Pro Glu Gln Asn Val Pro Lys Arg Lys Arg Ser Leu Lys Ala Val Val 
     850                855                860
Thr Ala Ala Thr Met Ser Asn Lys Phe Thr Gln Lys Gly Asn Phe Arg 
 865                870                875                880
Pro Asn Gly Glu Ala Lys Ser Glu Leu Cys Glu Asn Leu Glu Thr Pro 
                 885                890                895
Ala Leu Ala Thr Lys Gln Thr Tyr Val Thr Tyr Thr Asn His Ala Ile 
             900                905                910



<210> 4040
<211> 3431
<212> DNA
<213> Homo sapiens
<308> U92457
<400> 4040

tcatgggtc  ctagggatt  ccgaaatgc  tgggaagag  ggcttgggc  ggtggtggg  60
ccggctgcc  ctttgcctg  tcctcagcc  ttacggccc  tggatgcct  cctccctgg  120
aaagcccaa  ggccaccct  acatgaatt  catccgcat  gatggggac  tcacactgg  180
aggcctgtt  ccggtgcat  gccggggct  agagggcaa  ccctgtgga  aacttaaga  240
ggaaaaggg  atccaccgg  tggaggcca  gctgttcgc  ctggatcgc  tcaacaacg  300
cccggacct  ctgcctaac  tcacgctgg  cgcccgcat  ctggacacc  gctccaggg  360
cacccatgc  ctcgagcag  cgctgacct  tgtgcaggc  ctcatcgag  aggatggca  420
agaggtccg  tgtggcagt  gcggcccac  catcatcac  aagcctgaa  gtgtggtgg  480
tgtcatcgg  gcttcaggg  gctcggtct  catcatggt  gccaacatc  ttcgcctct  540
caagatacc  cagatcagc  acgcctcca  agcgccaga  ctgagtgac  acagccgct  600
cgacttctt  tcccgcgtg  tgccctcgg  cacgtacca  gcccaggcc  tggtggaca  660
cgtccgcgc  ctcaagtgg  actatgtgt  cacagtggc  tcggagggc  gctatggtg  720
gagcggtgt  gaggccttc  tccagaagt  ccgtgagga  gggggcgtg  gcatcgccc  780
gtcggtgaa  ataccacgg  agcccaagg  aggcgagtt  gacaagatc  tccgccgcc  840
cctggagac  tcgaacgcc  gggcagtca  catctttgc  aacgaggat  acatcaggc  900
tgtgctgga  gcagcacga  gggccaacc  gacaggcca  ttcttctgg  tgggctctg  960
cagctgggg  tccaagatt  cacctgtgc  gcacctgga  gaggtggct  agggtgctg  1020
cacgatcct  cccaagagg  tgtccgtac  aggcttcga  cgctacttc  ccagccgca  1080
gctggacaa  aaccggcgc  acatctggt  tgccgagtt  tgggaggac  acttccact  1140
caagctgag  cgccacgcc  tcaagaagg  cagccacgt  aagaagtgc  ccaaccgtg  1200
gcgaattgg  caggattca  cttatgagc  ggaggggaa  gtgcagttt  tgatcgatg  1260
cgtgtacgc  atgggccac  cgctgcacg  catgcaccg  gacctgtgt  ccggccgcg  1320
ggggctctg  ccgcgcatg  accctgtag  tggcaccca  ctgcttaag  acatccgaa  1380
cgtcaactt  tcaggcatc  cagggaacc  tgtgacctt  aatgagaat  gagatgcgc  1440
tgggcgcta  gacatctac  aataccagc  gcgcaacga  tctgccgag  acaaggtca  1500
tggctcctg  actgaccac  tgcacctta  aatagagcg  atgcactgg  cggggagcg  1560
gcagcagct  ccccgctcc  tctgcagcc  gccctgcca  ccgggtgag  ggaagaaga  1620
agtgaaggg  atgccttgc  gctggcact  cgagccttg  acagggtac  agtaccagg  1680
ggaccgcta  acctgtaag  cgtgtccct  tgacatgcg  cccacagag  accgcacgg  1740
ctgccggcc  atccccatc  tcaagcttg  gtggggctc  ccctgggcc  tgctgcccc  1800
cttcctggc  gtggtgggc  tcgctgcca  gttgttcgt  gtgatcacc  ttgtgcgct  1860
caacgacac  cccatcgtc  aggcctcgg  ccgtgaact  agctacgtg  tgctggcag  1920
catcttcct  tgctatgcc  ccaccttcc  catgatcgc  gagcccgac  ttggcacct  1980
ctcgctgcg  cgaatcttc  tgggactag  gatgagcat  agctatgca  ccctgctca  2040
caagaccaa  cgcatctac  gcatcttcg  gcagggcaa  cgctcggtc  gtgccccac  2100
cttcatcag  cccgcctca  agctggcca  caccttcag  ctcatctcg  tgcagctgc  2160
gggcatctg  gtgtggttt  tggtggacc  ctcccactc  gtggtggac  tccaggacc  2220
gcggacact  gacccccgc  tcgccaggg  tgtgctcaa  tgtgacatc  cggacctgt  2280
gctcatctg  ctgctgggc  acagcatgc  gctcatggt  acgtgcacc  tgtatgcca  2340
caagacacg  ggcgtgccc  agaccttca  tgaggccaa  cccattggc  tcaccatgt  2400
caccacttg  atcgtctgg  tggccttca  ccccatctt  tttggcacc  cgcagtcgg  2460
cgacaagct  tacatccag  cgacgacgc  gacggtctc  gtgagtctg  gcgcctcgg  2520
gtccctggg  atgctctac  tgcccaaag  ctacatcat  ctcttccac  cggagcaga  2580
cgtgcccaa  cgcaagcgc  gcctcaaag  cgtcgttac  gcggccacc  tgtccaaca  2640
gttcacgca  aagggcaac  tccggccca  cggagaggc  aagtctgag  tctgcgaga  2700
ccttgaggc  ccagcgctg  ccaccaaac  gacttacgt  acttacacc  accatgcaa  2760
ctagcgagt  catggagct  agcagcagg  ggaggagcc  tgaccctgt  gaaggtgcg  2820
cgggccagg  ccacaccca  gggcccagc  gtcttgcct  cccgtgggc  cccacggac  2880
tggcttggt  ctgagatag  agagccccc  gccatcact  ctggcagcc  gggcaaacc  2940
ggtgagcaa  aggaggacg  ggggccggg  cggtgccag  ctaccacaa  aacctgcgt  3000
ttggaccat  gcccctccc  gccccaaac  acaggggct  aggtcgtgt  ggccccagt  3060
ctagatctc  ccctccctt  gtctctgtc  gtgctgttg  cgacccctc  gtctgtctc  3120
agccctgtc  ttctgttct  ttatctctt  gtttcacct  ttccctctc  ggcgtcccc  3180
gctgcttgt  ctcttggcc  tttctgtgt  tcctttctg  ctcttgcct  cgcctctct  3240
tctcatcct  tttgtcctc  gctcctcct  ctttcttgg  tcccaccag  gtcactttt  3300
tgccgtttt  tttcctgtt  tcctctgct  cattctcgt  cagccattg  tcccctctc  3360
ctgccaccc  tccccagtt  accaaacct  acatgttgc  aaagaaaaa  aaaaaaagg  3420
attcctgca  c  3431



<210> 4041
<211> 912
<212> PRT
<213> Homo sapiens
<308> Q14833
<400> 4041

Met Pro Gly Lys Arg Gly Leu Gly Trp Trp Trp Ala Arg Leu Pro Leu 
  1               5                  10                  15
Cys Leu Leu Leu Ser Leu Tyr Gly Pro Trp Met Pro Ser Ser Leu Gly 
             20                  25                  30
Lys Pro Lys Gly His Pro His Met Asn Ser Ile Arg Ile Asp Gly Asp 
         35                  40                  45
Ile Thr Leu Gly Gly Leu Phe Pro Val His Gly Arg Gly Ser Glu Gly 
     50                  55                  60
Lys Pro Cys Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu 
 65                  70                  75                  80
Ala Met Leu Phe Ala Leu Asp Arg Ile Asn Asn Asp Pro Asp Leu Leu 
                 85                  90                  95
Pro Asn Ile Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
             100                105                110
Thr His Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu 
         115                120                125
Lys Asp Gly Thr Glu Val Arg Cys Gly Ser Gly Gly Pro Pro Ile Ile 
     130                135                140
Thr Lys Pro Glu Arg Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
 145                150                155                160
Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln 
                 165                170                175
Ile Ser Tyr Ala Ser Thr Ala Pro Asp Leu Ser Asp Asn Ser Arg Tyr 
             180                185                190
Asp Phe Phe Ser Arg Val Val Pro Ser Asp Thr Tyr Gln Ala Gln Ala 
         195                200                205
Met Val Asp Ile Val Arg Ala Leu Lys Trp Asn Tyr Val Ser Thr Val 
     210                215                220
Ala Ser Glu Gly Ser Tyr Gly Glu Ser Gly Val Glu Ala Phe Ile Gln 
 225                230                235                240
Lys Ser Arg Glu Asp Gly Gly Val Cys Ile Ala Gln Ser Val Lys Ile 
                 245                250                255
Pro Arg Glu Pro Lys Ala Gly Glu Phe Asp Lys Ile Ile Arg Arg Leu 
             260                265                270
Leu Glu Thr Ser Asn Ala Arg Ala Val Ile Ile Phe Ala Asn Glu Asp 
         275                280                285
Asp Ile Arg Arg Val Leu Glu Ala Ala Arg Arg Ala Asn Gln Thr Gly 
     290                295                300
His Phe Phe Trp Met Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro 
 305                310                315                320
Val Leu His Leu Glu Glu Val Ala Glu Gly Ala Val Thr Ile Leu Pro 
                 325                330                335
Lys Arg Met Ser Val Arg Gly Phe Asp Arg Tyr Phe Ser Ser Arg Thr 
             340                345                350
Leu Asp Asn Asn Arg Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Asp 
         355                360                365
Asn Phe His Cys Lys Leu Ser Arg His Ala Leu Lys Lys Gly Ser His 
     370                375                380
Val Lys Lys Cys Thr Asn Arg Glu Arg Ile Gly Gln Asp Ser Ala Tyr 
 385                390                395                400
Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ala Met 
                 405                410                415
Gly His Ala Leu His Ala Met His Arg Asp Leu Cys Pro Gly Arg Val 
             420                425                430
Gly Leu Cys Pro Arg Met Asp Pro Val Asp Gly Thr Gln Leu Leu Lys 
         435                440                445
Tyr Ile Arg Asn Val Asn Phe Ser Gly Ile Ala Gly Asn Pro Val Thr 
     450                455                460
Phe Asn Glu Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Tyr Gln Tyr 
 465                470                475                480
Gln Leu Arg Asn Asp Ser Ala Glu Tyr Lys Val Ile Gly Ser Trp Thr 
                 485                490                495
Asp His Leu His Leu Arg Ile Glu Arg Met His Trp Pro Gly Ser Gly 
             500                505                510
Gln Gln Leu Pro Arg Ser Ile Cys Ser Leu Pro Cys Gln Pro Gly Glu 
         515                520                525
Arg Lys Lys Thr Val Lys Gly Met Pro Cys Cys Trp His Cys Glu Pro 
     530                535                540
Cys Thr Gly Tyr Gln Tyr Gln Val Asp Arg Tyr Thr Cys Lys Thr Cys 
 545                550                555                560
Pro Tyr Asp Met Arg Pro Thr Glu Asn Arg Thr Gly Cys Arg Pro Ile 
                 565                570                575
Pro Ile Ile Lys Leu Glu Trp Gly Ser Pro Trp Ala Val Leu Pro Leu 
             580                585                590
Phe Leu Ala Val Val Gly Ile Ala Ala Thr Leu Phe Val Val Ile Thr 
         595                600                605
Phe Val Arg Tyr Asn Asp Thr Pro Ile Val Lys Ala Ser Gly Arg Glu 
     610                615                620
Leu Ser Tyr Val Leu Leu Ala Gly Ile Phe Leu Cys Tyr Ala Thr Thr 
 625                630                635                640
Phe Leu Met Ile Ala Glu Pro Asp Leu Gly Thr Cys Ser Leu Arg Arg 
                 645                650                655
Ile Phe Leu Gly Leu Gly Met Ser Ile Ser Tyr Ala Ala Leu Leu Thr 
             660                665                670
Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val 
         675                680                685
Ser Ala Pro Arg Phe Ile Ser Pro Ala Ser Gln Leu Ala Ile Thr Phe 
     690                695                700
Ser Leu Ile Ser Leu Gln Leu Leu Gly Ile Cys Val Trp Phe Val Val 
 705                710                715                720
Asp Pro Ser His Ser Val Val Asp Phe Gln Asp Gln Arg Thr Leu Asp 
                 725                730                735
Pro Arg Phe Ala Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser 
             740                745                750
Leu Ile Cys Leu Leu Gly Tyr Ser Met Leu Leu Met Val Thr Cys Thr 
         755                760                765
Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala 
     770                775                780
Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val Trp Leu Ala 
 785                790                795                800
Phe Ile Pro Ile Phe Phe Gly Thr Ser Gln Ser Ala Asp Lys Leu Tyr 
                 805                810                815
Ile Gln Thr Thr Thr Leu Thr Val Ser Val Ser Leu Ser Ala Ser Val 
             820                825                830
Ser Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile Leu Phe His 
         835                840                845
Pro Glu Gln Asn Val Pro Lys Arg Lys Arg Ser Leu Lys Ala Val Val 
     850                855                860
Thr Ala Ala Thr Met Ser Asn Lys Phe Thr Gln Lys Gly Asn Phe Arg 
 865                870                875                880
Pro Asn Gly Glu Ala Lys Ser Glu Leu Cys Glu Asn Leu Glu Ala Pro 
                 885                890                895
Ala Leu Ala Thr Lys Gln Thr Tyr Val Thr Tyr Thr Asn His Ala Ile 
             900                905                910



<210> 4042
<211> 1131
<212> DNA
<213> Rattus norvegicus
<308> M91234
<400> 4042

gaattcttt  cttttctcg  tgatcatca  taacatgga  agtgccttt  gtcctatcc  60
cacagcagc  cagtttcct  cccctatgg  taaaatgac  ccccaggtt  ggggacaaa  120
agagcccct  aaatagttt  aaagaatct  caactgtga  gaactttgt  ttgccagtc  180
ggattaatg  tttcttttc  atgggctat  gcccactga  acagtttgg  aaagggctg  240
tactaaagt  ctgaaagcc  caggtgaac  ggttacaat  cttttgtca  ctgcttagt  300
tttagcacc  aggttctaa  catctctcc  tccttttgt  attagttgt  actagaagc  360
tagtgtcat  tggaggctg  ttctcttga  agcaaagcc  ccaagctga  actgaaggg  420
ggtaggtac  ccttaaggg  aaatctaag  ccagagaga  agccggtaa  agctaggct  480
cctctctgc  cgcctttct  tttcataga  aaagcttgt  cttatattt  cagtggcct  540
tttgtccaa  aaaaggcct  ctggtttag  tgtgtgact  aatgctatt  gtcctcttc  600
gtggacctc  ctcctctag  ttcccttct  gttttctca  catcccacg  gagatgctt  660
ttagtaact  ttacaggtc  tctttacca  cgaggaaag  cagaatcct  ctagaggcc  720
gaaagaatg  tccagacat  gctagaagg  ccctcactt  tgcctgctc  cttcagacg  780
tgaaggtag  gagtgccag  tctgccccc  ggctccaag  gtgggtctc  taggggctg  840
aaaagcccc  ccaatctgg  taagatcaa  gaaagggta  gaagagaaa  ttacagaaa  900
ttgaagggt  aagctaagt  gctgagagt  agtataagt  acagagaaa  taaggttaa  960
caaagagaa  gagaaaaga  ggtaaaaag  cagaagcta  ggaagaaaa  agacaaaaa  1020
aagaggaag  tagagagct  aagagagat  aaagacaag  gaggaacat  tactggcca  1080
agtagttag  gaacctaag  agacagtta  ctggcaaca  aagagaatt  g  1131



<210> 4043
<211> 1859
<212> DNA
<213> Rattus norvegicus
<308> M91466
<400> 4043

ggcacgagc  gtctcggcg  tgtggccat  cctggcggc  ccttagcgg  tgtcctgag  60
ccgacacaa  cccggtaga  gactccccg  gcccggctg  cccggccat  cagctagag  120
cgcaggacg  gctgtacgt  gcgctggag  tggttatcg  cgcgctggc  gtggcgggc  180
acgtgctgg  gtgcgctgc  gtgggagcc  cgagtgctt  acagacccc  accaactac  240
ttctggtgt  cctggcgac  gcggacgtg  ctgtgggac  cttcgccat  ccctttgcc  300
tcaccatca  cctgggctt  tgcacggac  ttcacagct  cctcttcct  gcctgcttc  360
tgctggtgc  cacacagag  tccatcttt  gcctcttgg  ggtggctgt  gaccggtat  420
tggccattc  cgtcccgct  aggtataaa  gtttggtca  tggaacacg  gcaagaggg  480
tcatcgctg  cctctgggt  cttgccttt  gcattggac  gactccttt  ctgggttgg  540
acagtaaag  ccgtgccac  agcaactgc  cagaacctg  ggatggcat  acgaataag  600
gctgctgcc  tgtgaagtg  ctctttgag  acgtagttc  catgagcta  atggtttat  660
tcaacttct  tgggtgtgt  cttcctcca  tgctcatca  gatggtgat  tacatcaaa  720
tcttcatgg  ggcctgcaa  cagcttcag  acatggaac  gatggagca  tccaggacc  780
cgctgcagc  ggagatcca  gcggccaag  cactggcta  gattgtggg  atctttgct  840
tgtgttggc  ccccgtgca  gccatcaac  gcatcaccc  cttccatcc  gccctggcc  900
aggacaagc  caaatgggt  atgaatgtg  ccatcctcc  gtcacacgc  aattcagtt  960
tcaatccca  tgtctatgc  tacaggaac  gggacttcc  ctacagttt  cacaggatc  1020
tctccagat  cgttctctg  cagacggac  ccaagggtg  gagcgggca  gccggggga  1080
agtcaactt  cagtctgag  ttgtgacct  ggctctggc  tttgggaga  gaaggctta  1140
aataaacaa  ggactggac  cagctggtg  cctcactgt  gaggacaac  accctctca  1200
gcatgtggc  cacctgccc  gaacgcttg  caggagtca  acaagtctg  ctcacacgt  1260
catgcaact  ggaggccct  aggctaaca  atacactta  gaatctatt  agctgctct  1320
acttactgt  tggatggcg  gcggctaga  ctgattcca  aaactgttt  atttttaag  1380
atctgcctc  ttcgtggta  aaaaatgac  gaaacttac  ttactgtga  acactgtga  1440
ctatataat  taagtattt  tcacttaca  caatgggaa  ataaaagtt  gctctatta  1500
catatactc  ttccgggga  agcaactca  aaaactgaa  tataattct  cagtcaaga  1560
actgtagtg  taatttagg  aatggtact  ccctaagtt  gaaagtaga  ttatgtaac  1620
aaacaattt  agttcagta  cttccttgc  cacaaaaca  tagaggtgg  aacttggag  1680
gctgggtcc  tcctccact  cacccctgc  ttagagcta  gtactagag  ttgcttctc  1740
ctcacatta  agtttattg  atcccaaag  atgaaaatt  tactgagca  aatccccta  1800
ctgtgtatt  tatccagtg  aataaaact  tgaaaggtg  aaaaaaaaa  aaaaaaaaa  1859



<210> 4044
<211> 332
<212> PRT
<213> Rattus norvegicus
<308> P29276
<400> 4044

Met Gln Leu Glu Thr Gln Asp Ala Leu Tyr Val Ala Leu Glu Leu Val 
  1               5                  10                  15
Ile Ala Ala Leu Ala Val Ala Gly Asn Val Leu Val Cys Ala Ala Val 
             20                  25                  30
Gly Ala Ser Ser Ala Leu Gln Thr Pro Thr Asn Tyr Phe Leu Val Ser 
         35                  40                  45
Leu Ala Thr Ala Asp Val Ala Val Gly Leu Phe Ala Ile Pro Phe Ala 
     50                  55                  60
Ile Thr Ile Ser Leu Gly Phe Cys Thr Asp Phe His Ser Cys Leu Phe 
 65                  70                  75                  80
Leu Ala Cys Phe Val Leu Val Leu Thr Gln Ser Ser Ile Phe Ser Leu 
                 85                  90                  95
Leu Ala Val Ala Val Asp Arg Tyr Leu Ala Ile Arg Val Pro Leu Arg 
             100                105                110
Tyr Lys Gly Leu Val Thr Gly Thr Arg Ala Arg Gly Ile Ile Ala Val 
         115                120                125
Leu Trp Val Leu Ala Phe Gly Ile Gly Leu Thr Pro Phe Leu Gly Trp 
     130                135                140
Asn Ser Lys Asp Arg Ala Thr Ser Asn Cys Thr Glu Pro Gly Asp Gly 
 145                150                155                160
Ile Thr Asn Lys Ser Cys Cys Pro Val Lys Cys Leu Phe Glu Asn Val 
                 165                170                175
Val Pro Met Ser Tyr Met Val Tyr Phe Asn Phe Phe Gly Cys Val Leu 
             180                185                190
Pro Pro Leu Leu Ile Met Met Val Ile Tyr Ile Lys Ile Phe Met Val 
         195                200                205
Ala Cys Lys Gln Leu Gln His Met Glu Leu Met Glu His Ser Arg Thr 
     210                215                220
Thr Leu Gln Arg Glu Ile His Ala Ala Lys Ser Leu Ala Met Ile Val 
 225                230                235                240
Gly Ile Phe Ala Leu Cys Trp Leu Pro Val His Ala Ile Asn Cys Ile 
                 245                250                255
Thr Leu Phe His Pro Ala Leu Ala Lys Asp Lys Pro Lys Trp Val Met 
             260                265                270
Asn Val Ala Ile Leu Leu Ser His Ala Asn Ser Val Val Asn Pro Ile 
         275                280                285
Val Tyr Ala Tyr Arg Asn Arg Asp Phe Arg Tyr Ser Phe His Arg Ile 
     290                295                300
Ile Ser Arg Tyr Val Leu Cys Gln Thr Asp Thr Lys Gly Gly Ser Gly 
 305                310                315                320
Gln Ala Gly Gly Gln Ser Thr Phe Ser Leu Ser Leu 
                 325                330



<210> 4045
<211> 1687
<212> DNA
<213> Homo sapiens
<308> M97759
<400> 4045

cccagcccc  aggctcaga  gcggcaggc  gaggcgcgg  ccgggcgct  tggccatgc  60
cggcgggtc  cacgcggct  cccctcgcc  ggcgcgcct  cggtagggg  cgcccgggg  120
ccagctggc  cggccatgc  gctggagac  caggacgcg  tgtacgtgg  gctggagct  180
gtcatcgcc  cgctttcgg  ggcgggcaa  gtgctggtg  gcgccgcgg  gggcacggc  240
aacactctg  agacgccca  caactactt  ctggtgtcc  tggctgcgg  cgacgtggc  300
gtggggctc  tcgccatcc  ctttgccat  accatcagc  tgggcttct  cactgactt  360
tacggctgc  tcttcctcg  ctgcttcgt  ctggtgctc  cgcagagct  catcttcag  420
cttctggcc  tggcagtcg  cagatacct  gccatctgt  tcccgctca  gtataaaag  480
ttggtcacg  ggacccgag  aagaggggt  attgctgtc  tctgggtcc  tgcctttgg  540
atcggattg  ctccattcc  ggggtggaa  agtaaagac  gtgccacca  caactgcac  600
gaaccctgg  atggaacca  gaatgaaag  tgctgcctt  tgaagtgtc  ctttgagaa  660
gtggtcccc  tgagctaca  ggtatattt  aatttcttt  ggtgtgttc  gcccccact  720
cttataatg  tggtgatct  cattaagat  ttcctggtg  cctgcaggc  gcttcagcg  780
actgagctg  tggaccact  gaggaccac  ctccagcgg  agatccatg  agccaagtc  840
ctggccatg  ttgtgggga  ttttgccct  tgctggtta  ctgtgcatg  tgttaactg  900
gtcactctt  tccagccag  tcagggtaa  aataagccc  agtgggcaa  gaatatggc  960
attcttctg  cacatgcca  ttcagttgt  aatcccatt  tctatgctt  ccggaaccg  1020
gacttccgc  acacttttc  caaaattat  tccaggtat  ttctctgcc  agcagatgt  1080
aagagtggg  atggtcagg  tggggtaca  cctgctctc  gtgtgggcc  atgatctag  1140
ctctcgcct  ttccaggag  agatacaaa  ccacaagaa  caaagagga  acggctggt  1200
ttcattgtg  aagatagct  cacctcaca  ggaaatgga  tgcctctct  gagcacttc  1260
ctggagcta  cacgtatct  gctaatatg  atgtgtcag  agtagcacc  aggattgac  1320
aatatattt  tgatctatt  agctgcttt  actgtgtgg  ttatgccaa  agcttgaat  1380
gattctaac  gactctttt  tttttaaaa  tctgccttg  ttatggtgg  aaattactg  1440
aactatttt  ctgtgaaac  gtgtgaact  ttataatgc  aatactttt  aacttagag  1500
caatggaaa  ataaaagtt  actgtacta  aaatgtata  ttgttgcca  gaaggtgac  1560
tcaaaaatt  aaagtataa  tattcggcc  ggcatggtg  ctcacacct  taattccag  1620
actttggga  gccaaggca  gcggatcac  aggtcagga  ttcaaaacc  gcctgtcca  1680
tatagtg  1687



<210> 4046
<211> 332
<212> PRT
<213> Homo sapiens
<308> P29275
<400> 4046

Met Leu Leu Glu Thr Gln Asp Ala Leu Tyr Val Ala Leu Glu Leu Val 
  1               5                  10                  15
Ile Ala Ala Leu Ser Val Ala Gly Asn Val Leu Val Cys Ala Ala Val 
             20                  25                  30
Gly Thr Ala Asn Thr Leu Gln Thr Pro Thr Asn Tyr Phe Leu Val Ser 
         35                  40                  45
Leu Ala Ala Ala Asp Val Ala Val Gly Leu Phe Ala Ile Pro Phe Ala 
     50                  55                  60
Ile Thr Ile Ser Leu Gly Phe Cys Thr Asp Phe Tyr Gly Cys Leu Phe 
 65                  70                  75                  80
Leu Ala Cys Phe Val Leu Val Leu Thr Gln Ser Ser Ile Phe Ser Leu 
                 85                  90                  95
Leu Ala Val Ala Val Asp Arg Tyr Leu Ala Ile Cys Val Pro Leu Arg 
             100                105                110
Tyr Lys Ser Leu Val Thr Gly Thr Arg Ala Arg Gly Val Ile Ala Val 
         115                120                125
Leu Trp Val Leu Ala Phe Gly Ile Gly Leu Thr Pro Phe Leu Gly Trp 
     130                135                140
Asn Ser Lys Asp Ser Ala Thr Asn Asn Cys Thr Glu Pro Trp Asp Gly 
 145                150                155                160
Thr Thr Asn Glu Ser Cys Cys Leu Val Lys Cys Leu Phe Glu Asn Val 
                 165                170                175
Val Pro Met Ser Tyr Met Val Tyr Phe Asn Phe Phe Gly Cys Val Leu 
             180                185                190
Pro Pro Leu Leu Ile Met Leu Val Ile Tyr Ile Lys Ile Phe Leu Val 
         195                200                205
Ala Cys Arg Gln Leu Gln Arg Thr Glu Leu Met Asp His Ser Arg Thr 
     210                215                220
Thr Leu Gln Arg Glu Ile His Ala Ala Lys Ser Leu Ala Met Ile Val 
 225                230                235                240
Gly Ile Phe Ala Leu Cys Trp Leu Pro Val His Ala Val Asn Cys Val 
                 245                250                255
Thr Leu Phe Gln Pro Ala Gln Gly Lys Asn Lys Pro Lys Trp Ala Met 
             260                265                270
Asn Met Ala Ile Leu Leu Ser His Ala Asn Ser Val Val Asn Pro Ile 
         275                280                285
Val Tyr Ala Tyr Arg Asn Arg Asp Phe Arg Tyr Thr Phe His Lys Ile 
     290                295                300
Ile Ser Arg Tyr Leu Leu Cys Gln Ala Asp Val Lys Ser Gly Asn Gly 
 305                310                315                320
Gln Ala Gly Val Gln Pro Ala Leu Gly Val Gly Leu 
                 325                330



<210> 4047
<211> 1758
<212> DNA
<213> Rattus norvegicus
<308> M91590
<400> 4047

ttttttttt  tttgcctat  aaaaggttt  tttcttccc  atgctcaga  acgaagata  60
ggccttgct  gtccctccc  tgaaatctc  tcttcaagg  ttgggaggc  gaaggggac  120
tggcagcgg  tgagaaggc  gcgagcgag  cgcgaaccc  gcgggtgga  ggcggcgac  180
gcgcgcgca  catgggtga  aaacccggg  ccagggtct  caagaagtc  agccctaac  240
gcaagctca  cgtgtactt  ggcaagcgt  actttgtgg  tcacttgga  aaagtggat  300
ctgtcgatg  tgtggtgct  gtggatcct  actacttga  ggaccggaa  gtgtttgtg  360
ccctcacct  tgccttccg  tatggccga  aagacctgg  tgtactggg  ctgtctttc  420
gcaaagatc  gttcatcgc  acctaccag  ccttccccc  catgcccaa  ccacctcgg  480
cccccaccc  cctacagga  cgactgctg  agaagttgg  ccagcatgc  caccccttt  540
ttttcacaa  accccagaa  ttgccttgc  ccgtcacac  gcagccagg  ccggaggac  600
cagggaagg  ctgtggagt  gactttgag  ttcgagcct  ctgtgccaa  tctatagaa  660
aaaaaagcc  caaaaggaa  tccgtgcgg  ttatcatca  aaaggtaca  tttgctcct  720
agacacccg  cccccagcc  tcagctgaa  ccacacgcc  cttcctcat  tctgaccgg  780
ggtccctgc  cctagaggc  tccctggac  aagagctgt  ctaccatgg  gaacccctc  840
atgtcaacg  ccacgtcac  aacaattct  ccaagaccg  caagaagat  agagtgtct  900
tgagacagt  tgccgacat  tgcctcttc  gcaccgcgc  gtacaagtg  cctgtggct  960
agcttgaac  agatgacca  gtgtctccc  gttccacat  ctgcaaggt  tacaccata  1020
ccccgctgc  cagtgacaa  cgagagaag  gtggccttg  ccttgatgg  caactcaag  1080
acgaagaca  caacctggc  tccagcacc  ttgtgaagg  gggagccaa  aaggaggtg  1140
tgggaatcc  agtatccta  agggtcaag  tgaagctgg  ggtgtctcg  ggcggggat  1200
tctccgtgg  gctaccttt  gtcctaatg  accccaagc  ccacgacca  atcaccctt  1260
cccgacccc  gtcagcccc  cgggaaata  acatccctg  ggataccaa  ctcattgaa  1320
tcgatacca  ctatgccac  gacgacgac  tcgtgtttg  ggactttgc  aggcttcgg  1380
tgaagggga  gaaggatga  gactgtgat  accagttct  ctaggaaga  gggctggga  1440
aggtagggg  gggcaggac  gaggtccac  gcccttgcg  gtaggaggg  cccagcctc  1500
cctccttcc  cgttcgtcc  cccgagata  acactggac  catcactcg  tgaaagtgg  1560
cattaatct  ttgacttca  ctctgccac  ccagccctg  tccctaggg  ggcaagctg  1620
gtacacacc  aaagttttg  gaagggaag  gaacactga  agcaaggag  gaatgtaga  1680
aaaaggagt  gaaaggaca  ccatgtttg  cctcatacc  acccacccc  agtcaccac  1740
tctgcctcc  ccgaattc  1758



<210> 4048
<211> 410
<212> PRT
<213> Rattus norvegicus
<308> P29067
<400> 4048

Met Gly Glu Lys Pro Gly Thr Arg Val Phe Lys Lys Ser Ser Pro Asn 
  1               5                  10                  15
Cys Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
             20                  25                  30
Asp Lys Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Asp Tyr 
         35                  40                  45
Leu Lys Asp Arg Lys Val Phe Val Thr Leu Thr Cys Ala Phe Arg Tyr 
     50                  55                  60
Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp Leu 
 65                  70                  75                  80
Phe Ile Ala Thr Tyr Gln Ala Phe Pro Pro Met Pro Asn Pro Pro Arg 
                 85                  90                  95
Pro Pro Thr Arg Leu Gln Asp Arg Leu Leu Lys Lys Leu Gly Gln His 
             100                105                110
Ala His Pro Phe Phe Phe Thr Ile Pro Gln Asn Leu Pro Cys Ser Val 
         115                120                125
Thr Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp 
     130                135                140
Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Ile Glu Glu Lys Ser His 
 145                150                155                160
Lys Arg Asn Ser Val Arg Leu Ile Ile Arg Lys Val Gln Phe Ala Pro 
                 165                170                175
Glu Thr Pro Gly Pro Gln Pro Ser Ala Glu Thr Thr Arg His Phe Leu 
             180                185                190
Met Ser Asp Arg Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu 
         195                200                205
Leu Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Thr Asn 
     210                215                220
Asn Ser Ala Lys Thr Val Lys Lys Ile Arg Val Ser Val Arg Gln Tyr 
 225                230                235                240
Ala Asp Ile Cys Leu Phe Ser Thr Ala Gln Tyr Lys Cys Pro Val Ala 
                 245                250                255
Gln Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Thr Phe Cys Lys 
             260                265                270
Val Tyr Thr Ile Thr Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly 
         275                280                285
Leu Ala Leu Asp Gly Gln Leu Lys His Glu Asp Thr Asn Leu Ala Ser 
     290                295                300
Ser Thr Ile Val Lys Glu Gly Ala Asn Lys Glu Val Leu Gly Ile Leu 
 305                310                315                320
Val Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp 
                 325                330                335
Val Ser Val Glu Leu Pro Phe Val Leu Met His Pro Lys Pro His Asp 
             340                345                350
His Ile Thr Leu Pro Arg Pro Gln Ser Ala Pro Arg Glu Ile Asp Ile 
         355                360                365
Pro Val Asp Thr Asn Leu Ile Glu Phe Asp Thr Asn Tyr Ala Thr Asp 
     370                375                380
Asp Asp Ile Val Phe Glu Asp Phe Ala Arg Leu Arg Leu Lys Gly Met 
 385                390                395                400
Lys Asp Asp Asp Cys Asp Asp Gln Phe Cys 
                 405                410



<210> 4049
<211> 1527
<212> DNA
<213> Homo sapiens
<308> AF106941
<400> 4049

ggcgaggag  ctgcgagcg  gccggaacc  agcgggcgg  gggcgccgc  cctatgggg  60
agaaacccg  gaccagggt  ttcaagaag  cgagcccta  ctgcaagct  accgtgtac  120
tgggcaagc  ggacttcgt  gatcacctg  acaaagtgg  ccctgtaga  ggcgtggtg  180
ttgtggacc  tgactacct  aaggaccgc  aagtgtttg  gaccctcac  tgcgccttc  240
gctatggcc  tgaagacct  gatgtgctg  gcttgtcct  ccgcaaaga  ctgttcatc  300
ccacctacc  ggccttccc  ccggtgccc  acccacccc  gccccccac  cgcctgcag  360
accggctgc  gaggaagct  ggccagcat  cccacccct  cttcttcac  ataccccag  420
atcttccat  ctccgtcac  ctgcagcca  gcccagagg  tacaggaaa  gcctgcggg  480
tagactttg  gattcgagc  ttctgtgct  aatcactag  agagaaaag  cacaaaagg  540
actctgtgc  gctggtgat  cgaaaggtg  agttcgccc  ggagaaacc  ggcccccag  600
cttcagccg  aaccacacg  cacttcctc  tgtctgacc  gtccctgca  ctcgaggct  660
ccctggaca  ggagctgta  taccatggg  agcccctca  tgtaaatgt  cacgtcacc  720
acaactcca  caagaccgt  aagaagatc  aagtctctg  gagacagta  gccgacatc  780
gcctcttca  caccgccca  tacaagtgt  ctgtggctc  actcgaaca  gatgaccag  840
tatctccca  ctccacatt  tgtaaggtg  acaccataa  cccactgct  agcgacaac  900
gggagaagc  gggtctcgc  ctggatggg  aactcaagc  cgaggacac  aacctggct  960
ccagcacca  cgtgaagga  ggtgccaac  aggaggtgc  gggaatcct  gtgtcctac  1020
gggtcaagg  gaagctggt  gtgtctcga  gcggggatg  ctctgtgga  ctgcctttt  1080
ttcttatgc  ccccaagcc  cacgaccac  tccccctcc  cagacccca  tcagccgct  1140
cggagacag  tgtccctgt  gacaccaac  tcattgaat  tgataccaa  tatgccaca  1200
atgatgaca  tgtgtttga  gactttgcc  ggcttcggc  gaaggggat  aaggatgac  1260
actatgatg  tcaactctg  taggaagcg  ggtgggaaa  aagggaggg  atggggttg  1320
gagaggtga  ggcaggatt  agatcccca  tgtcaatgg  ggattgtcc  agcccctct  1380
cccttcccc  cacctggaa  cttcttcaa  caatccctt  acactctct  ccccatccc  1440
ccaagatac  cactggacc  tctcttgct  aatgtgggc  ttaattttt  gactgcagn  1500
ctgcttctc  agccccgcc  tgggtgg  1527



<210> 4050
<211> 409
<212> PRT
<213> Homo sapiens
<308> P32121
<400> 4050

Met Gly Glu Lys Pro Gly Thr Arg Val Phe Lys Lys Ser Ser Pro Asn 
  1               5                  10                  15
Cys Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
             20                  25                  30
Asp Lys Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Asp Tyr 
         35                  40                  45
Leu Lys Asp Arg Lys Val Phe Val Thr Leu Thr Cys Ala Phe Arg Tyr 
     50                  55                  60
Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp Leu 
 65                  70                  75                  80
Phe Ile Ala Thr Tyr Gln Ala Phe Pro Pro Val Pro Asn Pro Pro Arg 
                 85                  90                  95
Pro Pro Thr Arg Leu Gln Asp Arg Leu Leu Arg Lys Leu Gly Gln His 
             100                105                110
Ala His Pro Phe Phe Phe Thr Ile Pro Gln Asn Leu Pro Cys Ser Val 
         115                120                125
Thr Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp 
     130                135                140
Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Leu Glu Glu Lys Ser His 
 145                150                155                160
Lys Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Phe Ala Pro 
                 165                170                175
Glu Lys Pro Gly Pro Gln Pro Ser Ala Glu Thr Thr Arg His Phe Leu 
             180                185                190
Met Ser Asp Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu Leu 
         195                200                205
Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Thr Asn Asn 
     210                215                220
Ser Thr Lys Thr Val Lys Lys Ile Lys Val Ser Val Arg Gln Tyr Ala 
 225                230                235                240
Asp Ile Cys Leu Phe Ser Thr Ala Gln Tyr Lys Cys Pro Val Ala Gln 
                 245                250                255
Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Thr Phe Cys Lys Val 
             260                265                270
Tyr Thr Ile Thr Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly Leu 
         275                280                285
Ala Leu Asp Gly Lys Leu Lys His Glu Asp Thr Asn Leu Ala Ser Ser 
     290                295                300
Thr Ile Val Lys Glu Gly Ala Asn Lys Glu Val Leu Gly Ile Leu Val 
 305                310                315                320
Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp Val 
                 325                330                335
Ser Val Glu Leu Pro Phe Val Leu Met His Pro Lys Pro His Asp His 
             340                345                350
Ile Pro Leu Pro Arg Pro Gln Ser Ala Ala Pro Glu Thr Asp Val Pro 
         355                360                365
Val Asp Thr Asn Leu Ile Glu Phe Asp Thr Asn Tyr Ala Thr Asp Asp 
     370                375                380
Asp Ile Val Phe Glu Asp Phe Ala Arg Leu Arg Leu Lys Gly Met Lys 
 385                390                395                400
Asp Asp Asp Tyr Asp Asp Gln Leu Cys 
                 405



<210> 4051
<211> 1758
<212> DNA
<213> Rattus norvegicus
<308> M91590
<400> 4051

ttttttttt  tttgcctat  aaaaggttt  tttcttccc  atgctcaga  acgaagata  60
ggccttgct  gtccctccc  tgaaatctc  tcttcaagg  ttgggaggc  gaaggggac  120
tggcagcgg  tgagaaggc  gcgagcgag  cgcgaaccc  gcgggtgga  ggcggcgac  180
gcgcgcgca  catgggtga  aaacccggg  ccagggtct  caagaagtc  agccctaac  240
gcaagctca  cgtgtactt  ggcaagcgt  actttgtgg  tcacttgga  aaagtggat  300
ctgtcgatg  tgtggtgct  gtggatcct  actacttga  ggaccggaa  gtgtttgtg  360
ccctcacct  tgccttccg  tatggccga  aagacctgg  tgtactggg  ctgtctttc  420
gcaaagatc  gttcatcgc  acctaccag  ccttccccc  catgcccaa  ccacctcgg  480
cccccaccc  cctacagga  cgactgctg  agaagttgg  ccagcatgc  caccccttt  540
ttttcacaa  accccagaa  ttgccttgc  ccgtcacac  gcagccagg  ccggaggac  600
cagggaagg  ctgtggagt  gactttgag  ttcgagcct  ctgtgccaa  tctatagaa  660
aaaaaagcc  caaaaggaa  tccgtgcgg  ttatcatca  aaaggtaca  tttgctcct  720
agacacccg  cccccagcc  tcagctgaa  ccacacgcc  cttcctcat  tctgaccgg  780
ggtccctgc  cctagaggc  tccctggac  aagagctgt  ctaccatgg  gaacccctc  840
atgtcaacg  ccacgtcac  aacaattct  ccaagaccg  caagaagat  agagtgtct  900
tgagacagt  tgccgacat  tgcctcttc  gcaccgcgc  gtacaagtg  cctgtggct  960
agcttgaac  agatgacca  gtgtctccc  gttccacat  ctgcaaggt  tacaccata  1020
ccccgctgc  cagtgacaa  cgagagaag  gtggccttg  ccttgatgg  caactcaag  1080
acgaagaca  caacctggc  tccagcacc  ttgtgaagg  gggagccaa  aaggaggtg  1140
tgggaatcc  agtatccta  agggtcaag  tgaagctgg  ggtgtctcg  ggcggggat  1200
tctccgtgg  gctaccttt  gtcctaatg  accccaagc  ccacgacca  atcaccctt  1260
cccgacccc  gtcagcccc  cgggaaata  acatccctg  ggataccaa  ctcattgaa  1320
tcgatacca  ctatgccac  gacgacgac  tcgtgtttg  ggactttgc  aggcttcgg  1380
tgaagggga  gaaggatga  gactgtgat  accagttct  ctaggaaga  gggctggga  1440
aggtagggg  gggcaggac  gaggtccac  gcccttgcg  gtaggaggg  cccagcctc  1500
cctccttcc  cgttcgtcc  cccgagata  acactggac  catcactcg  tgaaagtgg  1560
cattaatct  ttgacttca  ctctgccac  ccagccctg  tccctaggg  ggcaagctg  1620
gtacacacc  aaagttttg  gaagggaag  gaacactga  agcaaggag  gaatgtaga  1680
aaaaggagt  gaaaggaca  ccatgtttg  cctcatacc  acccacccc  agtcaccac  1740
tctgcctcc  ccgaattc  1758



<210> 4052
<211> 410
<212> PRT
<213> Rattus norvegicus
<308> P29067
<400> 4052

Met Gly Glu Lys Pro Gly Thr Arg Val Phe Lys Lys Ser Ser Pro Asn 
  1               5                  10                  15
Cys Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
             20                  25                  30
Asp Lys Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Asp Tyr 
         35                  40                  45
Leu Lys Asp Arg Lys Val Phe Val Thr Leu Thr Cys Ala Phe Arg Tyr 
     50                  55                  60
Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp Leu 
 65                  70                  75                  80
Phe Ile Ala Thr Tyr Gln Ala Phe Pro Pro Met Pro Asn Pro Pro Arg 
                 85                  90                  95
Pro Pro Thr Arg Leu Gln Asp Arg Leu Leu Lys Lys Leu Gly Gln His 
             100                105                110
Ala His Pro Phe Phe Phe Thr Ile Pro Gln Asn Leu Pro Cys Ser Val 
         115                120                125
Thr Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp 
     130                135                140
Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Ile Glu Glu Lys Ser His 
 145                150                155                160
Lys Arg Asn Ser Val Arg Leu Ile Ile Arg Lys Val Gln Phe Ala Pro 
                 165                170                175
Glu Thr Pro Gly Pro Gln Pro Ser Ala Glu Thr Thr Arg His Phe Leu 
             180                185                190
Met Ser Asp Arg Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu 
         195                200                205
Leu Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Thr Asn 
     210                215                220
Asn Ser Ala Lys Thr Val Lys Lys Ile Arg Val Ser Val Arg Gln Tyr 
 225                230                235                240
Ala Asp Ile Cys Leu Phe Ser Thr Ala Gln Tyr Lys Cys Pro Val Ala 
                 245                250                255
Gln Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Thr Phe Cys Lys 
             260                265                270
Val Tyr Thr Ile Thr Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly 
         275                280                285
Leu Ala Leu Asp Gly Gln Leu Lys His Glu Asp Thr Asn Leu Ala Ser 
     290                295                300
Ser Thr Ile Val Lys Glu Gly Ala Asn Lys Glu Val Leu Gly Ile Leu 
 305                310                315                320
Val Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp 
                 325                330                335
Val Ser Val Glu Leu Pro Phe Val Leu Met His Pro Lys Pro His Asp 
             340                345                350
His Ile Thr Leu Pro Arg Pro Gln Ser Ala Pro Arg Glu Ile Asp Ile 
         355                360                365
Pro Val Asp Thr Asn Leu Ile Glu Phe Asp Thr Asn Tyr Ala Thr Asp 
     370                375                380
Asp Asp Ile Val Phe Glu Asp Phe Ala Arg Leu Arg Leu Lys Gly Met 
 385                390                395                400
Lys Asp Asp Asp Cys Asp Asp Gln Phe Cys 
                 405                410



<210> 4053
<211> 1527
<212> DNA
<213> Homo sapiens
<308> AF106941
<400> 4053

ggcgaggag  ctgcgagcg  gccggaacc  agcgggcgg  gggcgccgc  cctatgggg  60
agaaacccg  gaccagggt  ttcaagaag  cgagcccta  ctgcaagct  accgtgtac  120
tgggcaagc  ggacttcgt  gatcacctg  acaaagtgg  ccctgtaga  ggcgtggtg  180
ttgtggacc  tgactacct  aaggaccgc  aagtgtttg  gaccctcac  tgcgccttc  240
gctatggcc  tgaagacct  gatgtgctg  gcttgtcct  ccgcaaaga  ctgttcatc  300
ccacctacc  ggccttccc  ccggtgccc  acccacccc  gccccccac  cgcctgcag  360
accggctgc  gaggaagct  ggccagcat  cccacccct  cttcttcac  ataccccag  420
atcttccat  ctccgtcac  ctgcagcca  gcccagagg  tacaggaaa  gcctgcggg  480
tagactttg  gattcgagc  ttctgtgct  aatcactag  agagaaaag  cacaaaagg  540
actctgtgc  gctggtgat  cgaaaggtg  agttcgccc  ggagaaacc  ggcccccag  600
cttcagccg  aaccacacg  cacttcctc  tgtctgacc  gtccctgca  ctcgaggct  660
ccctggaca  ggagctgta  taccatggg  agcccctca  tgtaaatgt  cacgtcacc  720
acaactcca  caagaccgt  aagaagatc  aagtctctg  gagacagta  gccgacatc  780
gcctcttca  caccgccca  tacaagtgt  ctgtggctc  actcgaaca  gatgaccag  840
tatctccca  ctccacatt  tgtaaggtg  acaccataa  cccactgct  agcgacaac  900
gggagaagc  gggtctcgc  ctggatggg  aactcaagc  cgaggacac  aacctggct  960
ccagcacca  cgtgaagga  ggtgccaac  aggaggtgc  gggaatcct  gtgtcctac  1020
gggtcaagg  gaagctggt  gtgtctcga  gcggggatg  ctctgtgga  ctgcctttt  1080
ttcttatgc  ccccaagcc  cacgaccac  tccccctcc  cagacccca  tcagccgct  1140
cggagacag  tgtccctgt  gacaccaac  tcattgaat  tgataccaa  tatgccaca  1200
atgatgaca  tgtgtttga  gactttgcc  ggcttcggc  gaaggggat  aaggatgac  1260
actatgatg  tcaactctg  taggaagcg  ggtgggaaa  aagggaggg  atggggttg  1320
gagaggtga  ggcaggatt  agatcccca  tgtcaatgg  ggattgtcc  agcccctct  1380
cccttcccc  cacctggaa  cttcttcaa  caatccctt  acactctct  ccccatccc  1440
ccaagatac  cactggacc  tctcttgct  aatgtgggc  ttaattttt  gactgcagn  1500
ctgcttctc  agccccgcc  tgggtgg  1527



<210> 4054
<211> 409
<212> PRT
<213> Homo sapiens
<308> P32121
<400> 4054

Met Gly Glu Lys Pro Gly Thr Arg Val Phe Lys Lys Ser Ser Pro Asn 
  1               5                  10                  15
Cys Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
             20                  25                  30
Asp Lys Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Asp Tyr 
         35                  40                  45
Leu Lys Asp Arg Lys Val Phe Val Thr Leu Thr Cys Ala Phe Arg Tyr 
     50                  55                  60
Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp Leu 
 65                  70                  75                  80
Phe Ile Ala Thr Tyr Gln Ala Phe Pro Pro Val Pro Asn Pro Pro Arg 
                 85                  90                  95
Pro Pro Thr Arg Leu Gln Asp Arg Leu Leu Arg Lys Leu Gly Gln His 
             100                105                110
Ala His Pro Phe Phe Phe Thr Ile Pro Gln Asn Leu Pro Cys Ser Val 
         115                120                125
Thr Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp 
     130                135                140
Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Leu Glu Glu Lys Ser His 
 145                150                155                160
Lys Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Phe Ala Pro 
                 165                170                175
Glu Lys Pro Gly Pro Gln Pro Ser Ala Glu Thr Thr Arg His Phe Leu 
             180                185                190
Met Ser Asp Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu Leu 
         195                200                205
Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Thr Asn Asn 
     210                215                220
Ser Thr Lys Thr Val Lys Lys Ile Lys Val Ser Val Arg Gln Tyr Ala 
 225                230                235                240
Asp Ile Cys Leu Phe Ser Thr Ala Gln Tyr Lys Cys Pro Val Ala Gln 
                 245                250                255
Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Thr Phe Cys Lys Val 
             260                265                270
Tyr Thr Ile Thr Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly Leu 
         275                280                285
Ala Leu Asp Gly Lys Leu Lys His Glu Asp Thr Asn Leu Ala Ser Ser 
     290                295                300
Thr Ile Val Lys Glu Gly Ala Asn Lys Glu Val Leu Gly Ile Leu Val 
 305                310                315                320
Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp Val 
                 325                330                335
Ser Val Glu Leu Pro Phe Val Leu Met His Pro Lys Pro His Asp His 
             340                345                350
Ile Pro Leu Pro Arg Pro Gln Ser Ala Ala Pro Glu Thr Asp Val Pro 
         355                360                365
Val Asp Thr Asn Leu Ile Glu Phe Asp Thr Asn Tyr Ala Thr Asp Asp 
     370                375                380
Asp Ile Val Phe Glu Asp Phe Ala Arg Leu Arg Leu Lys Gly Met Lys 
 385                390                395                400
Asp Asp Asp Tyr Asp Asp Gln Leu Cys 
                 405



<210> 4055
<211> 1065
<212> DNA
<213> Rattus norvegicus
<308> M91595
<400> 4055

tctagaagg  ctgaacttc  tcgggactc  ctcaaggtc  ttgttccta  caacacgag  60
gctgtgtgt  agctccgaa  tttctaagg  caagattgc  tttgtgttt  cccagcagt  120
agttcacag  cggccacgt  ggaagtgag  aaactaagt  cttccaaat  gaactaaac  180
aaaagacag  agacaaaag  acgggctct  tcctactcc  cgccgattc  acccacgct  240
gcaagttat  cttactctc  ctgagcagg  gattccagg  tgaagggag  aaagtcctg  300
ctagggaag  gtaggggga  ccgccgaat  ccctagtaa  gtagggtgg  caagtgggc  360
tgtgcgcaa  cacgtgctc  cacgcagga  tgccttggg  gggaaggga  tggtctcca  420
aagggggag  ggagaaggc  gggggggcg  ggagaagca  gctttttag  acccggcag  480
agcggggga  gagaaagaa  gcaaggagg  gtctcccgc  ctcgccagg  ccgtgccac  540
tgcccgcta  ctcgccgcg  tacggtttc  cactagcca  catgctgcc  agattgggc  600
gccccgcgc  gccgctgct  ctgccgtcg  tgctcttgc  gctgctgtt  ggcgcgggc  660
gttgcggtc  tggggtgcg  gccgaggtg  tgttccgct  cccaccctg  acgcccgag  720
gtctggccg  ctgcggacc  ccacccgac  cgccctgcg  cgagctggt  cgagagccc  780
gctgcggtt  ctgctccgt  tgcgcacga  aggagggcg  agcttgcgg  gtctacatc  840
cgcgctgcg  ccagacgtt  cgctgttac  ccaacccgg  ctccgagct  cccctgaag  900
cactggtca  cggcgcggg  acctgtgaa  agagacgcg  gggcgccac  ccacagcag  960
ttgcaggta  tgcggactg  gagcactag  tcgggggtt  ggagaaact  gtagctcag  1020
ggggtctcc  ggctggcaa  cctcacgtg  ggaaagaga  tcgac  1065



<210> 4056
<211> 128
<212> PRT
<213> Rattus norvegicus
<308> AAA91899
<400> 4056

Met Leu Pro Arg Leu Gly Gly Pro Ala Leu Pro Leu Leu Leu Pro Ser 
  1               5                  10                  15
Leu Leu Leu Leu Leu Leu Leu Gly Ala Gly Gly Cys Gly Pro Gly Val 
             20                  25                  30
Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu 
         35                  40                  45
Ala Ala Cys Gly Pro Pro Pro Asp Ala Pro Cys Ala Glu Leu Val Arg 
     50                  55                  60
Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Gln Glu Gly Glu 
 65                  70                  75                  80
Ala Cys Gly Val Tyr Ile Pro Arg Cys Ala Gln Thr Leu Arg Cys Tyr 
                 85                  90                  95
Pro Asn Pro Gly Ser Glu Leu Pro Leu Lys Ala Leu Val Thr Gly Ala 
             100                105                110
Gly Thr Cys Glu Lys Arg Arg Val Gly Ala Thr Pro Gln Gln Val Ala 
         115                120                125



<210> 4057
<211> 1421
<212> DNA
<213> Homo sapiens
<308> XM_002636
<400> 4057

ggcgaggga  gaggaagaa  cggaggagg  ggctcccgc  ctcgcaggg  cgtgccacc  60
gcccgcccg  ccgctcgct  gctcgcccg  cgcgccgcg  tgccgaccg  cagcatgct  120
ccgagagtg  gctgccccg  gctgccgct  ccgccgccg  cgctgctgc  gctgctgct  180
ctgctactg  gcgcgagtg  cggcggcgg  ggggcgcgc  cggaggtgc  gttccgctg  240
ccgccctgc  cacccgagc  cctggccgc  tgcgggccc  cgccggttg  gccgcccgc  300
gcggtggcc  cagtggccg  aggcgcccg  atgccatgc  cggagctcg  ccgggagcc  360
ggctgcggc  gctgctcgg  gtgcgcccg  ctggagggc  aggcgtgcg  cgtctacac  420
ccgcgctgc  gccaggggc  gcgctgcta  ccccacccg  gctccgagc  gcccctgca  480
gcgctggtc  tgggcgagg  cacttgtga  aagcgccgg  acgccgagt  tggcgccag  540
ccggagcag  ttgcagaca  tggcgatga  cactcagaa  gaggcctgg  ggagaacca  600
gtggacagc  ccatgaaca  gttgggcgg  ggaggcagt  ctggccgga  gcccctcaa  660
tcgggtatg  aggagctgg  cgtgttccg  gagaaggtc  ctgagcagc  ccggcagat  720
ggcaagggt  gcaagcatc  ccttggcct  gaggagccc  agaagctgc  accaccccc  780
gccaggact  cctgccaac  ggaactgga  caggtcctg  agcggatct  caccatgcg  840
cttccggat  agcggggcc  tctggagca  ctctactcc  tgcacatcc  caactgtga  900
aagcatggc  tgtacaacc  caaacagtg  aagatgtct  tgaacgggc  gcgtgggga  960
tgctggtgt  tgaacccca  caccgggaa  ctgatccag  gagccccca  catccgggg  1020
gaccccgag  gtcatctct  ctacaatga  cagcaggag  ctcgcgggg  gcacaccca  1080
cggatgcag  agaccgcag  cagccggtg  ctggcgccc  tgccccccg  ccctctcca  1140
acaccggca  aaaacggag  gtgcttggg  ggtgggtgc  ggaggattt  ccagttctg  1200
cacacgtat  tatatttgg  aagagacca  caccgagct  ggcacctcc  cggcctctc  1260
cttcccagc  gcagatgcc  cacctgctc  ttcttgctt  ccccggggg  ggaaggggg  1320
tgtggtcgg  gagctgggg  acaggtttg  ggaggggga  gagaaattt  tatttttga  1380
cccctgtgt  ccttttgca  aagattaaa  gaaggaaaa  t  1421



<210> 4058
<211> 325
<212> PRT
<213> Homo sapiens
<308> XP_002636
<400> 4058

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
  1               5                  10                  15
Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly Gly Gly Gly 
             20                  25                  30
Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu 
         35                  40                  45
Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val 
     50                  55                  60
Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg 
 65                  70                  75                  80
Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu 
                 85                  90                  95
Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr 
             100                105                110
Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu 
         115                120                125
Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu 
     130                135                140
Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu 
 145                150                155                160
Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala 
                 165                170                175
Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg 
             180                185                190
Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His 
         195                200                205
His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg 
     210                215                220
Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr 
 225                230                235                240
Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu 
                 245                250                255
His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys 
             260                265                270
Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro 
         275                280                285
Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro 
     290                295                300
Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His 
 305                310                315                320
Thr Gln Arg Met Gln 
                 325



<210> 4059
<211> 1065
<212> DNA
<213> Rattus norvegicus
<308> M91595
<400> 4059

tctagaagg  ctgaacttc  tcgggactc  ctcaaggtc  ttgttccta  caacacgag  60
gctgtgtgt  agctccgaa  tttctaagg  caagattgc  tttgtgttt  cccagcagt  120
agttcacag  cggccacgt  ggaagtgag  aaactaagt  cttccaaat  gaactaaac  180
aaaagacag  agacaaaag  acgggctct  tcctactcc  cgccgattc  acccacgct  240
gcaagttat  cttactctc  ctgagcagg  gattccagg  tgaagggag  aaagtcctg  300
ctagggaag  gtaggggga  ccgccgaat  ccctagtaa  gtagggtgg  caagtgggc  360
tgtgcgcaa  cacgtgctc  cacgcagga  tgccttggg  gggaaggga  tggtctcca  420
aagggggag  ggagaaggc  gggggggcg  ggagaagca  gctttttag  acccggcag  480
agcggggga  gagaaagaa  gcaaggagg  gtctcccgc  ctcgccagg  ccgtgccac  540
tgcccgcta  ctcgccgcg  tacggtttc  cactagcca  catgctgcc  agattgggc  600
gccccgcgc  gccgctgct  ctgccgtcg  tgctcttgc  gctgctgtt  ggcgcgggc  660
gttgcggtc  tggggtgcg  gccgaggtg  tgttccgct  cccaccctg  acgcccgag  720
gtctggccg  ctgcggacc  ccacccgac  cgccctgcg  cgagctggt  cgagagccc  780
gctgcggtt  ctgctccgt  tgcgcacga  aggagggcg  agcttgcgg  gtctacatc  840
cgcgctgcg  ccagacgtt  cgctgttac  ccaacccgg  ctccgagct  cccctgaag  900
cactggtca  cggcgcggg  acctgtgaa  agagacgcg  gggcgccac  ccacagcag  960
ttgcaggta  tgcggactg  gagcactag  tcgggggtt  ggagaaact  gtagctcag  1020
ggggtctcc  ggctggcaa  cctcacgtg  ggaaagaga  tcgac  1065



<210> 4060
<211> 128
<212> PRT
<213> Rattus norvegicus
<308> AAA91899
<400> 4060

Met Leu Pro Arg Leu Gly Gly Pro Ala Leu Pro Leu Leu Leu Pro Ser 
  1               5                  10                  15
Leu Leu Leu Leu Leu Leu Leu Gly Ala Gly Gly Cys Gly Pro Gly Val 
             20                  25                  30
Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu 
         35                  40                  45
Ala Ala Cys Gly Pro Pro Pro Asp Ala Pro Cys Ala Glu Leu Val Arg 
     50                  55                  60
Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Gln Glu Gly Glu 
 65                  70                  75                  80
Ala Cys Gly Val Tyr Ile Pro Arg Cys Ala Gln Thr Leu Arg Cys Tyr 
                 85                  90                  95
Pro Asn Pro Gly Ser Glu Leu Pro Leu Lys Ala Leu Val Thr Gly Ala 
             100                105                110
Gly Thr Cys Glu Lys Arg Arg Val Gly Ala Thr Pro Gln Gln Val Ala 
         115                120                125



<210> 4061
<211> 1421
<212> DNA
<213> Homo sapiens
<308> XM_002636
<400> 4061

ggcgaggga  gaggaagaa  cggaggagg  ggctcccgc  ctcgcaggg  cgtgccacc  60
gcccgcccg  ccgctcgct  gctcgcccg  cgcgccgcg  tgccgaccg  cagcatgct  120
ccgagagtg  gctgccccg  gctgccgct  ccgccgccg  cgctgctgc  gctgctgct  180
ctgctactg  gcgcgagtg  cggcggcgg  ggggcgcgc  cggaggtgc  gttccgctg  240
ccgccctgc  cacccgagc  cctggccgc  tgcgggccc  cgccggttg  gccgcccgc  300
gcggtggcc  cagtggccg  aggcgcccg  atgccatgc  cggagctcg  ccgggagcc  360
ggctgcggc  gctgctcgg  gtgcgcccg  ctggagggc  aggcgtgcg  cgtctacac  420
ccgcgctgc  gccaggggc  gcgctgcta  ccccacccg  gctccgagc  gcccctgca  480
gcgctggtc  tgggcgagg  cacttgtga  aagcgccgg  acgccgagt  tggcgccag  540
ccggagcag  ttgcagaca  tggcgatga  cactcagaa  gaggcctgg  ggagaacca  600
gtggacagc  ccatgaaca  gttgggcgg  ggaggcagt  ctggccgga  gcccctcaa  660
tcgggtatg  aggagctgg  cgtgttccg  gagaaggtc  ctgagcagc  ccggcagat  720
ggcaagggt  gcaagcatc  ccttggcct  gaggagccc  agaagctgc  accaccccc  780
gccaggact  cctgccaac  ggaactgga  caggtcctg  agcggatct  caccatgcg  840
cttccggat  agcggggcc  tctggagca  ctctactcc  tgcacatcc  caactgtga  900
aagcatggc  tgtacaacc  caaacagtg  aagatgtct  tgaacgggc  gcgtgggga  960
tgctggtgt  tgaacccca  caccgggaa  ctgatccag  gagccccca  catccgggg  1020
gaccccgag  gtcatctct  ctacaatga  cagcaggag  ctcgcgggg  gcacaccca  1080
cggatgcag  agaccgcag  cagccggtg  ctggcgccc  tgccccccg  ccctctcca  1140
acaccggca  aaaacggag  gtgcttggg  ggtgggtgc  ggaggattt  ccagttctg  1200
cacacgtat  tatatttgg  aagagacca  caccgagct  ggcacctcc  cggcctctc  1260
cttcccagc  gcagatgcc  cacctgctc  ttcttgctt  ccccggggg  ggaaggggg  1320
tgtggtcgg  gagctgggg  acaggtttg  ggaggggga  gagaaattt  tatttttga  1380
cccctgtgt  ccttttgca  aagattaaa  gaaggaaaa  t  1421



<210> 4062
<211> 325
<212> PRT
<213> Homo sapiens
<308> XP_002636
<400> 4062

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
  1               5                  10                  15
Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly Gly Gly Gly 
             20                  25                  30
Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu 
         35                  40                  45
Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val 
     50                  55                  60
Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg 
 65                  70                  75                  80
Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu 
                 85                  90                  95
Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr 
             100                105                110
Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu 
         115                120                125
Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu 
     130                135                140
Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu 
 145                150                155                160
Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala 
                 165                170                175
Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg 
             180                185                190
Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His 
         195                200                205
His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg 
     210                215                220
Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr 
 225                230                235                240
Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu 
                 245                250                255
His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys 
             260                265                270
Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro 
         275                280                285
Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro 
     290                295                300
Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His 
 305                310                315                320
Thr Gln Arg Met Gln 
                 325



<210> 4063
<211> 2648
<212> DNA
<213> Rattus norvegicus
<308> M91599
<400> 4063

catcaataa  gaggacccc  agaccctca  cagctcctc  agtgggcac  cctacctgc  60
gcaagcacc  tactggaca  acccccaac  catggagaa  aaactgcac  cggtacctg  120
cgggaacac  gtcaaattc  gctgtccag  tgcagggaa  cccatgccc  ccatccact  180
gctcaagaa  ggacaggcc  tccacgggg  gaatcgtat  ggaggcatt  ggctgcgtc  240
ccaacactg  agcctcgtg  tggagagcg  ggtgccctc  gaccgtggc  cgtacacgt  300
tcttgtgga  aactctctg  gtagcattc  ctacagcta  ctgctggat  tgctggagc  360
gtccccgca  cggcccatc  tgcaggcgg  actcccagc  aacaccacg  ctgtggttg  420
cagcaacgt  gagctgctg  gcaaggtgt  cagtgacgc  cagccgcac  tccagtggc  480
gaagcacat  gttatcaac  gcagcagtc  cggcgctga  ggtttcccc  acgtacaag  540
cctgaagac  acagacatc  atagctcag  ggtggaggt  ctgtatctg  ggaacgtgt  600
ggctgagga  gcaggggag  acacctgcc  ggcgggcaa  tccatcggc  tctcctacc  660
gtcagcgtg  ctcacagtg  tacccgcag  ggaagaaga  ctcgcgtgg  caacagcaa  720
atcggaggc  agatataca  atattatcc  atatgtcca  ggctcactg  ctttggttt  780
gctcctgct  ctggccggg  tgtatcacc  acaagcaat  cacggccac  actctcgac  840
gcctgtcac  gtacagaag  tgtcccggt  ccctttggc  cggcagttc  ccttggagt  900
gaggtcctc  ggcaagtca  gtttgtccc  ggtgcgagg  gtccggctc  cctccagtg  960
cccgccctt  ctcacgggc  ttgtgagtc  agacctacc  ctcgatcca  tttgggagt  1020
cccccggga  aggctggtg  tcggaaagc  cctgggtga  ggctgcttt  ggcaagtgg  1080
ttgtgcaga  gcccttggc  tggattcct  ccggccaga  caaaccagc  tcgtggctg  1140
gaagatgct  aaagacaat  cctccgaca  ggatttggc  gacctgatc  ctgagatgg  1200
gatgatgaa  ctaatcgga  gacacaaga  catcattaa  ctgctgggt  tctgcactc  1260
ggaagggcc  ctgtatgtg  ttgtggaat  tgcggccaa  ggaaacctt  gggaattcc  1320
ccgtgcccg  cgtccccca  gccctgatc  cagccctga  gggcctcgg  gcagcgaag  1380
accgctctc  ttcccggcc  tggtctcct  tgcctacca  gtggcccga  gcatgcagt  1440
tctggagtc  cggaagtgc  tccaccggg  cctggctgc  cgaaacgtg  tggtgaccg  1500
ggatgacgt  atgaagatc  ctgactttg  tctggcccg  ggtgtccac  acatcgact  1560
ctataagaa  accagcaat  gccgcctgc  agtcaagtg  atggctcct  aggcgttgt  1620
tgaccgtgt  tacacacac  agagtgacg  gtggtcctt  gggatcctg  tgtgggaaa  1680
cttcaccct  gggggctcc  cataccccg  catcccagt  gaggagctg  tctcactgc  1740
gcgagaggg  cacaggatg  agcggcccc  aaactgccc  tcagagctg  atgggctaa  1800
gagggagtg  tggcacgca  ctccttctc  gaggccgac  tttaagcag  tggtggaag  1860
tctggacaa  gtcctgctg  ctgtctctg  agagtacct  gacctccgc  tgacctttg  1920
accctattc  cccaacaat  gggatgcca  cagcacgtg  tcctccagc  actcggttt  1980
cagccacga  cctttgccc  tcgagccaa  ccccttccc  tttcctgag  cgcagacca  2040
atgagcctg  gaacgatgt  gcatgggct  gtaggcccg  ggccgtggg  ctccaacct  2100
tttcatcag  atttgacgt  ggcactgtc  tcaggcctc  gactcgagg  tactgctgg  2160
ccagatcct  tctctggcc  tgttttggg  aggcccatt  ttggtcttg  ggttcacag  2220
tgaggcctt  tgttccaaa  ttatgttcc  agctcagag  tcaactcct  gtctcaaga  2280
catggtcgt  cccttggac  catcctcaa  ggagcgaag  attaaggcc  tgacactta  2340
cctccaccc  aggggctct  cgggcctga  tgcaaatct  tggtcctaa  catttctag  2400
tccccaaac  acctagagg  ctcgggact  cactgcacc  ccgcccccg  agcccacaa  2460
cctcgccac  ctggtcccc  actccccac  gcttgttct  gcatcttgt  gaaggagcc  2520
cagctctgg  gtccttgag  gagggaagc  tgtggaaaa  acagaagaa  aaggcattt  2580
ataaattat  attattttt  aaaaaaaaa  aaaaaaatc  agaattctg  agaaggatc  2640
cgcgccat  2648



<210> 4064
<211> 650
<212> PRT
<213> Rattus norvegicus
<308> AAA41157
<400> 4064

Met Glu Lys Lys Leu His Ala Val Pro Ala Gly Asn Thr Val Lys Phe 
  1               5                  10                  15
Arg Cys Pro Ala Ala Gly Asn Pro Met Pro Thr Ile His Trp Leu Lys 
             20                  25                  30
Asn Gly Gln Ala Phe His Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu 
         35                  40                  45
Arg His Gln His Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp 
     50                  55                  60
Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn Ser Leu Gly Ser Ile Arg 
 65                  70                  75                  80
Tyr Ser Tyr Leu Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile 
                 85                  90                  95
Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala Val Val Gly Ser Asn 
             100                105                110
Val Glu Leu Leu Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln 
         115                120                125
Trp Leu Lys His Ile Val Ile Asn Gly Ser Ser Leu Gly Ala Asp Gly 
     130                135                140
Phe Pro Tyr Val Gln Val Leu Lys Thr Thr Asp Ile Asn Ser Ser Glu 
 145                150                155                160
Val Glu Val Leu Tyr Leu Arg Asn Val Ser Ala Glu Asp Ala Gly Glu 
                 165                170                175
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala 
             180                185                190
Trp Leu Thr Val Leu Pro Ala Glu Glu Glu Asp Leu Ala Trp Thr Thr 
         195                200                205
Ala Thr Ser Glu Ala Arg Tyr Thr Asp Ile Ile Leu Tyr Val His Gly 
     210                215                220
Ser Leu Ala Leu Val Leu Leu Leu Leu Leu Ala Gly Val Tyr His Arg 
 225                230                235                240
Gln Ala Ile His Gly His His Ser Arg Gln Pro Val Thr Val Gln Lys 
                 245                250                255
Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe Ser Leu Glu Ser Arg Ser 
             260                265                270
Ser Gly Lys Ser Ser Leu Ser Leu Val Arg Gly Val Arg Leu Ser Ser 
         275                280                285
Ser Gly Pro Pro Leu Leu Thr Gly Leu Val Ser Leu Asp Leu Pro Leu 
     290                295                300
Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg Leu Val Leu Gly Lys Pro 
 305                310                315                320
Leu Gly Glu Gly Cys Phe Gly Gln Val Val Cys Ala Glu Ala Leu Gly 
                 325                330                335
Met Asp Ser Ser Arg Pro Asp Gln Thr Ser Ile Val Ala Val Lys Met 
             340                345                350
Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ala Asp Leu Ile Ser Glu 
         355                360                365
Met Glu Met Met Lys Leu Ile Gly Arg His Lys Asn Ile Ile Asn Leu 
     370                375                380
Leu Gly Val Cys Thr Gln Glu Gly Pro Leu Tyr Val Ile Val Glu Tyr 
 385                390                395                400
Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro 
                 405                410                415
Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg Ser Ser Glu Gly Pro Leu 
             420                425                430
Ser Phe Pro Ala Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met 
         435                440                445
Gln Tyr Leu Glu Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala Arg 
     450                455                460
Asn Val Leu Val Thr Glu Asp Asp Val Met Lys Ile Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr Lys Lys Thr Ser Asn 
                 485                490                495
Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg 
             500                505                510
Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp 
         515                520                525
Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu 
     530                535                540
Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg Met Glu Arg Pro Pro 
 545                550                555                560
Asn Cys Pro Ser Glu Leu Tyr Gly Leu Met Arg Glu Cys Trp His Ala 
                 565                570                575
Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Ala Leu Asp 
             580                585                590
Lys Val Leu Leu Ala Val Ser Glu Glu Tyr Leu Asp Leu Arg Leu Thr 
         595                600                605
Phe Gly Pro Tyr Ser Pro Asn Asn Gly Asp Ala Ser Ser Thr Cys Ser 
     610                615                620
Ser Ser Asp Ser Val Phe Ser His Asp Pro Leu Pro Leu Glu Pro Ser 
 625                630                635                640
Pro Phe Pro Phe Pro Glu Ala Gln Thr Thr 
                 645                650



<210> 4065
<211> 3015
<212> DNA
<213> Homo sapiens
<308> NM_002011
<400> 4065

ccgaggagc  ctcgggctg  ctgcggacc  tgccgcgtg  aggggtcgc  gccggctgg  60
gctgggagt  aggcggcgg  ggagccagg  gaggaggag  caggaaggc  gttggtggg  120
agtccagct  gggtccctg  gagctgtga  aaggagatg  ggctgctgc  ggccctgtt  180
ggggtcctg  tgagtgtgc  tgggcctcc  gtcttgtcc  tggaggcct  tgaggaagt  240
gagcttgag  cctgcctgg  tcccagcct  gagcagcaa  agcaggagc  gacagtagc  300
cttgggcag  ctgtgcggc  gtgctgtgg  cgggctgag  gtggtggcc  ctggtacaa  360
gagggcagt  gcctggcac  tgctggccg  gtacggggc  ggaggggcc  cctagagat  420
gccagcttc  tacctgagg  tgctggccg  tacctctgc  tggcacgag  ctccatgat  480
gtcctgcag  atctcacct  gattacagg  gactccttg  cctccagca  cgatgatga  540
gaccccaag  cccataggg  cctctcgaa  aggcacagt  acccccagc  agcacccta  600
tggacacac  cccagcgca  ggagaagaa  ctgcatgca  tacctgcgg  gaacaccgt  660
aagttccgc  gtccagctg  aggcaaccc  acgcccacc  tccgctggc  taaggatgg  720
caggccttt  atggggaga  ccgcattgg  ggcattcgg  tgcgccatc  gcactggag  780
ctcgtgatg  agagcgtgg  gccctcgga  cgcggcaca  acacctgcc  ggtagagaa  840
gctgtgggc  gcatccgct  taactacct  ctagatgtg  tggagcggt  cccgcaccg  900
cccatcctg  aggccgggc  cccggccaa  accacagcc  tggtgggca  cgacgtgga  960
ctgctgtgc  aggtgtaca  cgatgccca  ccccacatc  agtggctga  gcacatcgt  1020
atcaacggc  gcagcttcg  agccgacgg  ttcccctat  tgcaagtcc  aaagactgc  1080
gacatcaat  gctcagagg  ggaggtcct  tacctgcgg  acgtgtcag  cgaggacgc  1140
ggcgagtac  cctgcctcg  aggcaattc  atcggcctc  cctaccagt  tgcctggct  1200
acggtgctg  cagaggagg  ccccacatg  accgcagca  cgcccgagg  caggtatac  1260
gacatcatc  tgtacgcgt  gggctccct  gccttggct  tgctcctgc  gctggccgg  1320
ctgtatcga  ggcaggcgc  ccacggccg  cacccccgc  cgcccgcca  tgtgcagaa  1380
ctctcccgc  tccctctgg  ccgacagtt  tccctggag  caggctctt  cggcaagtc  1440
agctcatcc  tggtacgag  cgtgcgtct  tcctccagc  gccccgcct  gctcgccgg  1500
ctcgtgagt  tagatctac  tctcgaccc  ctatgggag  tcccccggg  caggctggt  1560
cttgggaag  ccctaggcg  gggctgctt  ggccaggta  tacgtgcag  ggcctttgg  1620
atggaccct  cccggcctg  ccaagccag  actgtggcc  tcaagatgc  caaagacaa  1680
gcctctgac  aggacctgg  cgacctggt  tcggagatg  aggtgatga  gctgatcgg  1740
cgacacaag  acatcatca  cctgcttgg  gtctgcacc  aggaagggc  cctgtacgt  1800
atcgtggag  gcgccgcca  gggaaacct  cgggagttc  tgcgggccc  gcgcccccc  1860
ggccccgac  tcagccccg  cggtcctcg  agcagtgag  ggccgctct  cttcccagt  1920
ctggtctcc  gcgcctacc  ggtggcccg  ggcatgcag  atctggagt  ccggaagtg  1980
atccaccgg  acctggctg  ccgcaatgt  ctggtgact  aggacaatg  gatgaagat  2040
gctgacttt  ggctggccc  cggcgtcca  cacattgac  actataaga  aaccagcaa  2100
ggccgcctg  ctgtgaagt  gatggcgcc  gaggccttg  ttgaccggg  gtacacaca  2160
cagagtgac  tgtggtctt  tgggatcct  ctatgggag  tcttcaccc  cgggggctc  2220
ccgtatcct  gcatcccgg  ggaggagct  ttctcgctg  tgcgggagg  acatcggat  2280
gaccgaccc  cacactgcc  cccagagct  tacgggctg  tgcgtgagt  ctggcacgc  2340
gcgccctcc  agaggccta  cttcaagca  ctggtggag  cgctggaca  ggtcctgct  2400
gccgtctct  aggagtacc  cgacctccg  ctgaccttc  gaccctatt  cccctctgg  2460
ggggacgcc  gcagcacct  ctcctccag  gattctgtc  tcagccacg  ccccctgcc  2520
ttgggatcc  gctccttcc  cttcgggtc  ggggtgcag  catgagcaa  gctcaaggc  2580
gtgcaggca  ataggctgg  ggccttggg  cttggggct  agccacagc  tgacacagt  2640
ctcgacctt  atagcatgg  gcccctggc  cagagttgc  gtgccgtgt  caagggccg  2700
gcccttgcc  ttggagctg  cgtgcctgt  tcctgatgg  ccaaatgtc  gggttctgc  2760
cggcttctt  gaccatggc  cttagtccc  atcccgggt  tggctgagc  tggctggag  2820
gctgctatg  taaacctcc  gcctcccaa  accagcagg  ggttctggg  ctctgaacc  2880
cctttcccc  cacctcccc  tgctgctgc  gccccagcg  cttgacggg  gcattggcc  2940
ctgagccca  agaagctgg  agcctgccg  aaacaggag  aaatggcgt  ttataaatt  3000
tttttttga  ataaa  3015



<210> 4066
<211> 802
<212> PRT
<213> Homo sapiens
<308> P22455
<400> 4066

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
  1               5                  10                  15
Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
             20                  25                  30
Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
         35                  40                  45
Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
     50                  55                  60
His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
 65                  70                  75                  80
Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                 85                  90                  95
Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
             100                105                110
Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
         115                120                125
Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
     130                135                140
Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
 145                150                155                160
Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                 165                170                175
Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
             180                185                190
Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
         195                200                205
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
     210                215                220
Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
 225                230                235                240
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                 245                250                255
Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
             260                265                270
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
         275                280                285
Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
     290                295                300
Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
 305                310                315                320
Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                 325                330                335
Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
             340                345                350
Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
         355                360                365
Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
     370                375                380
Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
 385                390                395                400
Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                 405                410                415
Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
             420                425                430
Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
         435                440                445
Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
     450                455                460
Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
 465                470                475                480
Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                 485                490                495
Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
             500                505                510
Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
         515                520                525
Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
     530                535                540
Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
 545                550                555                560
Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                 565                570                575
Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
             580                585                590
Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
         595                600                605
Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
     610                615                620
Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
 625                630                635                640
Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                 645                650                655
Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
             660                665                670
Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
         675                680                685
Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
     690                695                700
Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
 705                710                715                720
Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                 725                730                735
Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
             740                745                750
Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
         755                760                765
Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
     770                775                780
Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
 785                790                795                800
Gln Thr 
                 805



<210> 4067
<211> 2648
<212> DNA
<213> Rattus norvegicus
<308> M91599
<400> 4067

catcaataa  gaggacccc  agaccctca  cagctcctc  agtgggcac  cctacctgc  60
gcaagcacc  tactggaca  acccccaac  catggagaa  aaactgcac  cggtacctg  120
cgggaacac  gtcaaattc  gctgtccag  tgcagggaa  cccatgccc  ccatccact  180
gctcaagaa  ggacaggcc  tccacgggg  gaatcgtat  ggaggcatt  ggctgcgtc  240
ccaacactg  agcctcgtg  tggagagcg  ggtgccctc  gaccgtggc  cgtacacgt  300
tcttgtgga  aactctctg  gtagcattc  ctacagcta  ctgctggat  tgctggagc  360
gtccccgca  cggcccatc  tgcaggcgg  actcccagc  aacaccacg  ctgtggttg  420
cagcaacgt  gagctgctg  gcaaggtgt  cagtgacgc  cagccgcac  tccagtggc  480
gaagcacat  gttatcaac  gcagcagtc  cggcgctga  ggtttcccc  acgtacaag  540
cctgaagac  acagacatc  atagctcag  ggtggaggt  ctgtatctg  ggaacgtgt  600
ggctgagga  gcaggggag  acacctgcc  ggcgggcaa  tccatcggc  tctcctacc  660
gtcagcgtg  ctcacagtg  tacccgcag  ggaagaaga  ctcgcgtgg  caacagcaa  720
atcggaggc  agatataca  atattatcc  atatgtcca  ggctcactg  ctttggttt  780
gctcctgct  ctggccggg  tgtatcacc  acaagcaat  cacggccac  actctcgac  840
gcctgtcac  gtacagaag  tgtcccggt  ccctttggc  cggcagttc  ccttggagt  900
gaggtcctc  ggcaagtca  gtttgtccc  ggtgcgagg  gtccggctc  cctccagtg  960
cccgccctt  ctcacgggc  ttgtgagtc  agacctacc  ctcgatcca  tttgggagt  1020
cccccggga  aggctggtg  tcggaaagc  cctgggtga  ggctgcttt  ggcaagtgg  1080
ttgtgcaga  gcccttggc  tggattcct  ccggccaga  caaaccagc  tcgtggctg  1140
gaagatgct  aaagacaat  cctccgaca  ggatttggc  gacctgatc  ctgagatgg  1200
gatgatgaa  ctaatcgga  gacacaaga  catcattaa  ctgctgggt  tctgcactc  1260
ggaagggcc  ctgtatgtg  ttgtggaat  tgcggccaa  ggaaacctt  gggaattcc  1320
ccgtgcccg  cgtccccca  gccctgatc  cagccctga  gggcctcgg  gcagcgaag  1380
accgctctc  ttcccggcc  tggtctcct  tgcctacca  gtggcccga  gcatgcagt  1440
tctggagtc  cggaagtgc  tccaccggg  cctggctgc  cgaaacgtg  tggtgaccg  1500
ggatgacgt  atgaagatc  ctgactttg  tctggcccg  ggtgtccac  acatcgact  1560
ctataagaa  accagcaat  gccgcctgc  agtcaagtg  atggctcct  aggcgttgt  1620
tgaccgtgt  tacacacac  agagtgacg  gtggtcctt  gggatcctg  tgtgggaaa  1680
cttcaccct  gggggctcc  cataccccg  catcccagt  gaggagctg  tctcactgc  1740
gcgagaggg  cacaggatg  agcggcccc  aaactgccc  tcagagctg  atgggctaa  1800
gagggagtg  tggcacgca  ctccttctc  gaggccgac  tttaagcag  tggtggaag  1860
tctggacaa  gtcctgctg  ctgtctctg  agagtacct  gacctccgc  tgacctttg  1920
accctattc  cccaacaat  gggatgcca  cagcacgtg  tcctccagc  actcggttt  1980
cagccacga  cctttgccc  tcgagccaa  ccccttccc  tttcctgag  cgcagacca  2040
atgagcctg  gaacgatgt  gcatgggct  gtaggcccg  ggccgtggg  ctccaacct  2100
tttcatcag  atttgacgt  ggcactgtc  tcaggcctc  gactcgagg  tactgctgg  2160
ccagatcct  tctctggcc  tgttttggg  aggcccatt  ttggtcttg  ggttcacag  2220
tgaggcctt  tgttccaaa  ttatgttcc  agctcagag  tcaactcct  gtctcaaga  2280
catggtcgt  cccttggac  catcctcaa  ggagcgaag  attaaggcc  tgacactta  2340
cctccaccc  aggggctct  cgggcctga  tgcaaatct  tggtcctaa  catttctag  2400
tccccaaac  acctagagg  ctcgggact  cactgcacc  ccgcccccg  agcccacaa  2460
cctcgccac  ctggtcccc  actccccac  gcttgttct  gcatcttgt  gaaggagcc  2520
cagctctgg  gtccttgag  gagggaagc  tgtggaaaa  acagaagaa  aaggcattt  2580
ataaattat  attattttt  aaaaaaaaa  aaaaaaatc  agaattctg  agaaggatc  2640
cgcgccat  2648



<210> 4068
<211> 650
<212> PRT
<213> Rattus norvegicus
<308> AAA41157
<400> 4068

Met Glu Lys Lys Leu His Ala Val Pro Ala Gly Asn Thr Val Lys Phe 
  1               5                  10                  15
Arg Cys Pro Ala Ala Gly Asn Pro Met Pro Thr Ile His Trp Leu Lys 
             20                  25                  30
Asn Gly Gln Ala Phe His Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu 
         35                  40                  45
Arg His Gln His Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp 
     50                  55                  60
Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn Ser Leu Gly Ser Ile Arg 
 65                  70                  75                  80
Tyr Ser Tyr Leu Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile 
                 85                  90                  95
Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala Val Val Gly Ser Asn 
             100                105                110
Val Glu Leu Leu Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln 
         115                120                125
Trp Leu Lys His Ile Val Ile Asn Gly Ser Ser Leu Gly Ala Asp Gly 
     130                135                140
Phe Pro Tyr Val Gln Val Leu Lys Thr Thr Asp Ile Asn Ser Ser Glu 
 145                150                155                160
Val Glu Val Leu Tyr Leu Arg Asn Val Ser Ala Glu Asp Ala Gly Glu 
                 165                170                175
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala 
             180                185                190
Trp Leu Thr Val Leu Pro Ala Glu Glu Glu Asp Leu Ala Trp Thr Thr 
         195                200                205
Ala Thr Ser Glu Ala Arg Tyr Thr Asp Ile Ile Leu Tyr Val His Gly 
     210                215                220
Ser Leu Ala Leu Val Leu Leu Leu Leu Leu Ala Gly Val Tyr His Arg 
 225                230                235                240
Gln Ala Ile His Gly His His Ser Arg Gln Pro Val Thr Val Gln Lys 
                 245                250                255
Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe Ser Leu Glu Ser Arg Ser 
             260                265                270
Ser Gly Lys Ser Ser Leu Ser Leu Val Arg Gly Val Arg Leu Ser Ser 
         275                280                285
Ser Gly Pro Pro Leu Leu Thr Gly Leu Val Ser Leu Asp Leu Pro Leu 
     290                295                300
Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg Leu Val Leu Gly Lys Pro 
 305                310                315                320
Leu Gly Glu Gly Cys Phe Gly Gln Val Val Cys Ala Glu Ala Leu Gly 
                 325                330                335
Met Asp Ser Ser Arg Pro Asp Gln Thr Ser Ile Val Ala Val Lys Met 
             340                345                350
Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ala Asp Leu Ile Ser Glu 
         355                360                365
Met Glu Met Met Lys Leu Ile Gly Arg His Lys Asn Ile Ile Asn Leu 
     370                375                380
Leu Gly Val Cys Thr Gln Glu Gly Pro Leu Tyr Val Ile Val Glu Tyr 
 385                390                395                400
Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro 
                 405                410                415
Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg Ser Ser Glu Gly Pro Leu 
             420                425                430
Ser Phe Pro Ala Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met 
         435                440                445
Gln Tyr Leu Glu Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala Arg 
     450                455                460
Asn Val Leu Val Thr Glu Asp Asp Val Met Lys Ile Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr Lys Lys Thr Ser Asn 
                 485                490                495
Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg 
             500                505                510
Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp 
         515                520                525
Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu 
     530                535                540
Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg Met Glu Arg Pro Pro 
 545                550                555                560
Asn Cys Pro Ser Glu Leu Tyr Gly Leu Met Arg Glu Cys Trp His Ala 
                 565                570                575
Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Ala Leu Asp 
             580                585                590
Lys Val Leu Leu Ala Val Ser Glu Glu Tyr Leu Asp Leu Arg Leu Thr 
         595                600                605
Phe Gly Pro Tyr Ser Pro Asn Asn Gly Asp Ala Ser Ser Thr Cys Ser 
     610                615                620
Ser Ser Asp Ser Val Phe Ser His Asp Pro Leu Pro Leu Glu Pro Ser 
 625                630                635                640
Pro Phe Pro Phe Pro Glu Ala Gln Thr Thr 
                 645                650



<210> 4069
<211> 13095
<212> DNA
<213> Homo sapiens
<308> Y13901
<400> 4069

gaattcaag  tgtcctcct  cctcagtct  ctagtaact  gaactacag  cacccgtca  60
tgtgcccgg  cattccaca  ctatttaca  aattaactg  tcagttaca  ttctggcaa  120
cgtgctgaa  aaataacag  tcctaaata  ttacagcta  tattacaaa  caagcgctg  180
atgccaggc  tacacatac  gctaacatg  ctacttttt  caacaacct  ttgtgggtg  240
gactatcat  tgcctgttt  actgaaagg  cagtgaaga  tgaggcctt  tgtgatggt  300
ctgagagct  ggcctatga  gtccagccc  gtagtctgt  ctctgaacc  cttcaccct  360
tttctttct  catcctcac  gtagagacg  catctaaga  gagcttgca  gtccagagg  420
cttcctgaa  gaagtgagc  gagaataat  tgaaattaa  cagaccaag  ggcattcca  480
gaagagaga  tggtacgtg  aactgccca  gagtagcag  gtgggagcc  ggaggcgtg  540
gtcatggca  tctatgtat  aagagctat  ggaatctat  ggaaaattt  agggagtgg  600
tgacacagt  agatttgtg  tgtaagtat  actccgcag  ttgcgcagg  aacaaatga  660
ggagcagaa  gaaggggtt  tcctgtccg  tgcacggca  tgcgcagaa  acaggggag  720
caggcattc  ctgaagggt  aaaagcaag  agtagagct  ggtagtaga  tagaattta  780
gagcctggc  tggggcctg  gtggggcga  agaggcgga  ctgaatggg  tgtgtatag  840
ggggttgcg  gtaggggtg  gtgtatagg  tggggcggg  tcccgggag  gggctgact  900
ggtcggggg  ggggctctc  aggtgggcg  ggatcttgg  cacccctgg  cacacctct  960
tccggctcg  gctggtcta  gcggggcgg  cccgagggg  tgtggcagg  ggtgggcgg  1020
cccgggtgg  ggggggggg  gtggaagga  gggcgggcc  gagcaggag  gggcgggcc  1080
gaggggcgg  gcgggacag  aggtgggcc  ctcgcggca  gccgccgtc  cgggtacat  1140
cctcgctcc  ggccgagga  cgctcgggc  gtctgcgga  cctgccgcg  gcaggggtc  1200
cggccggct  gagctggga  tgaggcggc  gaggagcca  gtgaggagg  gccaggtga  1260
caggaccct  tgctgggcg  ggagtcacg  aggctcgag  tgagccgga  cccttgtgg  1320
cccggctgc  ctcccagcc  ccagggggc  agaggcggc  gggctacgg  gactgcccc  1380
cccggcgca  gggacctgg  cgtccgccg  gcggcaggg  gtggagggg  cggtaaatc  1440
gtaacccgc  gtgcacaca  ggccttttg  cccgctccg  ccaaagagc  ccccggccg  1500
ggagctggt  actcattgc  caccgaggc  ggggcaggc  ggccctgtg  agctaccct  1560
gggacccat  gattcgcac  tccccccag  ctggcccgg  aagggtggg  gaggacaag  1620
gcgcttgtc  ctgcggctg  cttcgcgcc  gcggcagag  tgagggacc  gaggccccg  1680
aaagttcag  cacttagtg  ccgggggcc  ccagcgcga  tgcgggagg  tgaaggaga  1740
cccaggact  tctgatgcc  aaggcaggc  ctccattcc  acgtggggg  tggtcggtc  1800
gcggtcagc  gccacgggt  actcgacta  ggactctga  atcagggca  cctggggta  1860
gaataaact  cccgggcct  cccacccac  cccagccca  gctgtgtac  caaagagct  1920
ccctccctg  caagccgag  ttggtaggg  gttttacca  ggaggatcc  actggattc  1980
agagttgag  tgggccaga  acagcagta  ctgagtcag  tagagaaga  caatgaggg  2040
cacagaggg  tgggcaaga  agcacatgt  cccagtttt  aaagccaat  gcttcagcg  2100
tcctgaagg  gcagacggt  tgaccaaag  gataggcag  ggcagagag  gagccctag  2160
atgttgagc  ggatcctgc  gggcacagg  agccattaa  ggcttgcaa  ctggggggc  2220
tgacatggc  gacttgcag  tttttttgt  tgttttttt  ttttatttt  tttttttat  2280
ttgtttttt  tgagacgga  tctcactct  tcgcccagg  tggagtgca  tggcgcgat  2340
tcggctcac  gcaagctcc  cctcccggg  tcgcgccat  ctcctgcct  agcctcccg  2400
gtagctggg  ctacaggcg  ccgccaccg  gcccggcta  ttttttgta  ttttagtag  2460
gacggggtt  caccgtgtt  gccaggatg  tctcgatct  ctgacctcg  gatccgccc  2520
cctcggcct  ccaaagtgc  gggattaca  gtgtgaacc  tcgcgccca  ccgacttgt  2580
gttttttaa  actctgctg  aagatgaag  ttgaagagc  gagggagag  atgtttcca  2640
aggcccatg  aagagatgg  catgacctg  cttgagaag  ggcagggga  gccagatgg  2700
ctggaagtg  agtggcagt  accaaggag  aggaggtgt  ataggcttc  cacgcaggg  2760
agatccaga  acaccagtg  cacccatag  cccctagga  tgcagtggt  acccgattc  2820
tttgtccca  ctgagactc  gttctgagt  ttctatttt  gggaacaga  gcgtccttg  2880
tagcatttg  aagaggata  ccagctggg  tgtgtgtac  tcacagcct  acagtaaca  2940
catccgaac  agaggtgac  ggctaaggg  agacccagg  caacaggtt  accgttcta  3000
ggccgggca  agggaggag  acattccaa  actctgtgt  cccagtgcc  acgcacgtt  3060
tctctttta  cctcaaaac  gtcctatga  gatataagc  agagagaga  agagacaag  3120
aattacaag  tggtgagag  caggatttg  acttggctc  ggcagatgg  aaattaggg  3180
ctgtattct  tacaaaacc  tgtgtgcct  agatggagt  ggtgcataa  aagcagagg  3240
atccagggt  gcggtcctg  ttgccacgg  aggggccgc  ttgtcagtt  tgaccaccc  3300
gccctggaa  tgtcagtaa  gctgtaagg  gtggggatc  gatcagatg  catccagat  3360
ctgaagttt  accttgtgt  atttttcac  ttctttttt  gctcttctg  aatcaattc  3420
tttatttag  aaaaaagaa  ttatgtgtg  cgagagcat  cagaagata  gtctccgtt  3480
tctgcttcc  tccaaaaaa  aatcccaaa  ctgctttct  tgaacgtgt  ccagggtcc  3540
agcaggact  agggagagc  ggaagccca  cccagaccc  ttgcacaac  taccgtggg  3600
aggccttag  ctctggcta  tacagagct  gttccagtc  gcactgcca  agcctggcc  3660
gggacttgg  cacatctgc  ggccacttc  tgtctcagt  tccttatct  caaaataag  3720
gaaaagccc  cacaaaggt  cacgtgtag  aggagctct  ttccctccc  attttagga  3780
ggcagttgg  gggaagtcc  gcttgggtc  ctgagagct  tgagaagga  atgcggctg  3840
tgctggccc  gttggggat  ctgctgagt  tgcctgggc  tccagtctt  tccctggag  3900
cctctgagg  agtggagct  ggtatggct  ctgaggtgg  agagggtgg  aggggtggg  3960
agagtgggc  ccaggaggg  gctgctggg  tgagcaaag  tggaaagga  ccttgccca  4020
gccctgaga  ggtggcggc  gggcagggc  caaccactg  gactcagtc  gtgcctggc  4080
tccagcaag  attcatcta  cactgtgtc  gcgagagag  actggcctt  cagggcgca  4140
ggccctaag  tgggctgca  agctggtgg  gagctcctt  cctgggtgt  tgtgcgtgt  4200
tgtgtgtgt  ctgtgcact  ggtgtgtga  ctaggaggt  caggcagca  gtgtggtat  4260
agcattatg  gggtgatat  ccccggtgc  gcatgaccc  gtatgtggc  ccaacagca  4320
gtgccttgt  tgtgtgtgt  tccgtatgt  tgtgtgtgt  tgcgtgtgt  tgtgtgtgt  4380
tgtgtgtct  ggccactgt  atgtgcact  aatgctgtg  gtgtgacat  ccccaagag  4440
gtggcattt  ccctgggtg  ggcatccgc  gcatgtggc  gtgtgggtg  caaggagtg  4500
tggctcctt  agcatgcgt  gcgaagtgc  tgtgccctg  atgtgcggt  tgttctctg  4560
acacaggag  ctgcctcag  tggggctgc  gggtctgct  acctctccc  ctgcccaca  4620
agccctgcc  ggctcccag  ctggagcag  aagagcagg  gctgacagt  gcccttggg  4680
agcctgtgc  gctgtgctg  gggcgggct  agcgtggtg  ccactggta  aaggagggc  4740
gtcgcctgg  acctgctgg  cgtgtacgg  gctggaggg  ccgcctaga  attgccagc  4800
tcctacctg  ggatgctgg  cgctacctc  gcctggcac  aggctccat  atcgtcctg  4860
agaatctca  cttgattac  ggtggtaag  gactctagc  gggagtgaa  ggatgccag  4920
ggagacaga  ctgcccccc  tggacctta  atgctccct  tgtccctga  gtagactcc  4980
tgacctcca  caacgatga  gaggacccc  agtcccata  ggacctctc  aataggcac  5040
gttaccccc  gcaaggtca  taggtctcc  aggacttgt  tcccgctgc  gctcatctg  5100
tcactgaga  gaggaggcc  gtgtgggaa  acacggtca  tctaggggc  ttcccctgc  5160
ctccagcac  ctactggac  cacccccag  gcatggaga  gaaactgca  gcagtacct  5220
cggggaaca  cgtcaagtt  cgctgtcca  ctgcaggca  ccccacgcc  accatccgc  5280
ggcttaagg  tggacaggc  tttcatggg  agaaccgca  tggaggcat  cgggtgagt  5340
tctgggttc  aagaccgtc  gctccccca  tttcattcc  tcatcagtc  cctcatacc  5400
acaagcata  ctataaatc  atcgaatga  tgaagcgat  gcggggccc  ggaaggagc  5460
ctggactgt  gacctgggc  gctctggtt  cccttctgc  actctctgg  aagtgactt  5520
acctctcag  ctcagcaac  ccctttgta  agggagaag  atcactgac  ggttggtct  5580
cataagcct  agcatctca  cgtcttgat  agaccctgc  gggtcggct  catgctgtc  5640
tgaggcaac  gagcctcag  gaaggcaag  gttggctca  agtagcaca  ctagggaga  5700
ggagagcta  aattccaaa  gctcaaacc  aaggctcaa  cgccctggg  agcctactc  5760
tttgtgcca  agtccttgg  ctgggcctg  tgttctcag  gcctagaga  cttgacaag  5820
gccctgtgg  caggatgag  atctagcct  ctggtcctc  ggccccctt  gtggacatg  5880
tccggtggt  ccggacact  tctctgcct  cagctgcgc  atcagcact  gagtctcgt  5940
atggagagc  tggtgccct  ggaccgcgg  acatacacc  gcctggtag  gaacgctgt  6000
ggcagcatc  gctataact  cctgctaga  gtgctgggt  agcgcgggg  tgggaacag  6060
ggaggcctg  cccattttg  gctcagttg  gccctcttg  tggggtcta  tctggcagg  6120
aggatggac  cagatgagt  aggcagctt  gtgagcagg  gggtcaggg  aaagcacag  6180
ggttagtgt  gggctggag  agcagaggt  tgccaagag  aaaaacaag  aggacatcc  6240
ggcagaggg  gcagcccga  cggagggcc  gagtataac  aacgccctg  acttgcagg  6300
cagcatatt  gtagggcgt  gcgtttata  ggggagcca  gtggtggag  gttttgaat  6360
ctaggctga  atgttgtcc  tgacccgaa  caataggga  ccagggaag  tttaagcag  6420
gtaagcagg  gacagacaa  aagctgcag  aaggtccct  ccttgaact  gaggaaggc  6480
ggagggagg  aaacagggt  cttctatgg  tgccagtgg  cagggttga  tgtctcgcc  6540
ggtccccag  gcggtcccc  caccggccc  tcctgcagg  cgggctccc  gccaacacc  6600
cagccgtgg  gggcagcga  gtggagctg  tgtgcaagg  gtacagcga  gcccagccc  6660
acatccagt  gctgaagca  atcgtcatc  acggcagca  cttcggagc  gacggtttc  6720
cctatgtgc  agtcctaaa  gtaaaaggt  caccctgct  cagcctggg  cccattctt  6780
tcccacctt  ggttggggg  ctccccagc  tccctgttg  ccacagtgt  gccccaggc  6840
ctgctgtga  cccagagca  gtcccccac  ccagactgc  gacatcaat  gctcagagg  6900
ggaggtcct  tacctgcgg  acgtgtcag  cgaggacgc  ggcgagtac  cctgcctcg  6960
aggcaattc  atcggcctc  cctaccagt  tgcctggct  acggtgctg  caggtgagc  7020
cctgaaggg  caggagatg  tgcgagatg  ccctctggg  cagcagtgg  ggctgtggc  7080
tgttgggtg  tcagtctct  ttggcctgt  gggtctggc  tggggggca  tgtgtggat  7140
tgtgggttt  agctgtatg  cagcccctc  gtgcctctc  acacgtggc  gtccatgtg  7200
ccgtctgct  aggtgtggg  gcctgggac  gggcataac  acagcttcc  ccgtgtgtg  7260
ccccacata  gttgggagc  gggagggac  gagttaggg  gcacggggc  gccagtctc  7320
ccactgacc  gtttgtctg  ctgtgtgtg  ccatgtgcg  gggcagagg  ggaccccac  7380
tggaccgca  cagcgcccg  ggccaggta  acggacatc  tcctgtacg  gtcgggctc  7440
ctggccttg  ctgtgctcc  gctgctggc  gggctgtat  gagggcagg  gctccacgg  7500
cggcacccc  gcccgcccg  cactgtgca  aagctctcc  gcttccctc  ggcccgaca  7560
gtactgggc  catccccca  ctcacatgt  acagcctga  tccagcagg  agaaccaag  7620
ctcccactt  gcagttctc  ctggagtca  gctcttccg  caagtcaag  tcatccctg  7680
tacgaggcg  gcgtctctc  tccagcggc  ccgccttgc  cgccggcct  gtgagtcta  7740
atctacctc  cgacccact  tgggagttc  cccgggaca  gtgcgctga  ctgtgtggg  7800
gcagggacg  gggcgccgg  ttgcagccc  ccctccgca  gagtgactc  gaggtctga  7860
gctggactt  ctccatctc  aggctggtg  ttgggaagc  cctaggcga  ggctgcttt  7920
gccaggtag  acgtgcaga  gcctttggc  tggaccctg  ccggcctga  caagccagc  7980
ctgtggccg  caagatgct  aaaggtgag  gtggcccgg  gtggtggct  acacctgta  8040
cgccagcac  ttaggaggc  gagggtggg  ggatcgctt  aatccagga  ttcgaggcc  8100
gcctgggca  catggcaag  cttcatctc  acaaaaaaa  aataagaaa  ttagttggg  8160
gtggtggtg  gtgccttta  tctcagtta  tagggaggc  gaggcagga  gatcccttg  8220
atccaggag  tggaggttg  agggagcca  gatcacgcc  ctgtattcc  gcctgggca  8280
cacagtgag  ccctatctg  aaaaataaa  aaataaata  aaataaaag  tgaacgtgg  8340
agcctggag  aggtgctat  gcattggga  taatagaag  ggctcacgg  gccaccagg  8400
gagccctgg  gctgggaga  gctgtggga  cccaccctt  aacctgcaa  tcacctctg  8460
tcctgaccc  ggcaagtga  ttctgagcc  cagttttcc  ttgtgtcat  tggggtaga  8520
aacagtccc  actcccagc  caaggattg  ggaaagtgc  tggctcata  tcagggctc  8580
ataaatctt  accactggg  tgatgatga  gagaagaat  tggtgtgac  ggcttgata  8640
cctgtgtca  cattagtct  tgtcagctt  gacttcaca  ctctttgtc  gcctcacag  8700
ccctctacc  ccttcctta  ggttccccc  agacacacc  tcagcctcc  ttggaccct  8760
cctaggtct  ccccccacg  ccactgctg  aggaggaca  cccttctgc  tgcacccag  8820
cccagcccc  gggtgctct  gctgggcac  cctgcaccc  acccatcag  gcctctcct  8880
gcagttccc  agccccctc  gcaagaatg  cctccactg  tcttctgct  ctcccctcc  8940
ctctacaca  ctggggcca  ctggtgctc  ctgggaggc  gggattgag  aatgcacat  9000
gtgtcattg  cccagggcc  caggtcagc  ccaggggct  agccagaga  gccaaagca  9060
ccttcttcc  aagctcccc  gctgcaccc  gcctgccgc  agctccctg  attcccagg  9120
cagttggaa  ccaggccct  gtcaaacag  ccccagggc  ccagcctgc  ttccgcacc  9180
agaagctct  accccatgc  gggactacc  ctgacccct  cagcggcag  ttccttcct  9240
ccttcctgc  ccgagctct  cccctctct  ctgtgtcct  ggcctgccc  ctggaaggc  9300
tgcctctta  atccttgat  cagttgcat  cttgcaact  ctgtgacag  cagggtgtg  9360
cccactgct  tgtttccca  aagacgaac  tgaggttca  agacgctag  agacttttt  9420
aaggccaca  agcctagca  ggattcagc  ctagaccta  gtagccctg  tccagtgct  9480
cttgtcctg  acctgcctc  gcatgctcc  tcgtgcagt  ggagggcag  ctctcaccc  9540
gtctgctgc  cttacagac  acgcctctg  caaggacct  gccgacctg  tctcggaga  9600
ggaggtgat  aagctgatc  gccgacaca  gaacatcat  aacctgctt  gtgtctgca  9660
ccaggaagg  ggggccgag  cggggctgg  tgcacgggc  gttagggtg  agagccaaa  9720
ctttggcag  ctctccacg  tccctccac  ccctctgca  ggcccctgt  cgtgatcgt  9780
gagtgcgcc  ccaagggaa  cctgcggga  ttcctgcgg  cccggcgcc  cccaggccc  9840
gacctcagc  ccgacggtc  tcggagcag  gaggggccg  tctccttcc  agtcctggt  9900
tcctgcgcc  accaggtgg  ccgaggcat  cagtatctg  agtcccgga  ggtataggc  9960
ctagggctc  gagcccctc  cagtctctc  agctccact  tcaggcctg  ggcattcaa  10020
gtcccgact  ctccctctc  gctcttttt  atgacccca  ctcagtgtc  ccaggcatt  10080
acgctttcc  gcattcccc  ctcgttcct  acccttccc  agaggggag  ggggacgca  10140
gagaaggca  tccccgttt  taaaccttg  cctcctcct  tgtaaagtg  gtggagggc  10200
cctgccccc  ggcctgctg  ggggtggtg  gtgctcaac  ccaggccag  tgtcctgag  10260
cacccaagc  cccgctccc  gcagtgtat  caccgggac  tggctgccc  caatgtgct  10320
gtgactgag  acaatgtga  gaagattgc  gactttggg  tggcccgcg  cgtccacca  10380
attgactac  ataagaaaa  cagcaacgt  agggagatg  ggcagaact  gatgggggt  10440
gaggggcac  gggcccggg  tggcaggca  gaggacctg  gggactctg  actgaggcc  10500
tctctcccc  ccagggccg  ctgcctgtg  agtggatgg  gcccgaggc  ttgtttgac  10560
gggtgtaca  acaccagag  gacgtgtga  tcctgccgg  ggtcactgt  ctaccccac  10620
aaaagggca  ggcactgcc  aaagtcacg  ggccccagg  gtcatgcgc  cgagggctc  10680
ttcagattt  gtctgggac  cgagtgggc  cagactcca  gaggagccc  ttccccaac  10740
gctgtggtg  gtcatgtct  tggggtccc  cgtcctagc  ccggtcgta  ggagggcgc  10800
gagccacac  gagccctgg  cctgcctcc  ggtggtctt  tgggatcct  ctatgggag  10860
tcttcaccc  cgggggctc  ccgtatcct  gcatcccgg  ggaggagct  ttctcgctg  10920
tgcgggagg  acatcggat  gaccgaccc  cacactgcc  cccagagct  tgaggcctc  10980
ccctgccct  gaccccact  tccagtcct  ctcctcctc  gccctgacc  tggcctcag  11040
gtgtgtccc  gccagaagg  caacactaa  aacaactcc  cgtcctcct  ctcctcttc  11100
tcttcctcc  cctcctctt  ctcctcctc  tcttcctcc  cctcctctt  ctcctcctc  11160
tcctcctcc  cctcttcct  ctcctcctc  tcctcctcc  cctcttcct  ctcctcctc  11220
tcctcctcc  cctcttcct  ctcctcctc  tcctcctcc  cctcctcct  ctcctcctc  11280
tcttcctcc  cctcctctt  ctcctcctc  tcctcctcc  cctcctcct  ctcctcttc  11340
tcctcctcc  cttcctcct  ctcctcctc  tcctcctcc  cttcctcct  ctcctcttc  11400
tcctcctcc  cttcctcct  ctcctcctg  tcctcttcc  cctcctcct  ttcctcctc  11460
tcctcctcc  cctcttcct  ctcctcagc  tagtggagt  tcctggcct  gcttctact  11520
atgaccctc  tatccctca  caaactccc  accaaactc  tccccaccc  gagaacccc  11580
ggtcctccc  ttcctcctg  aggcctgag  ctccctgtg  ccctccgcc  cacctctcg  11640
aggtacggg  tgatgcgtg  gtgctggca  gcagcgccc  cccagaggc  taccttcaa  11700
cagctggtg  aggcgctgg  caaggtcct  ctggccgtc  ctgaggagg  acagcccct  11760
ccacccacc  cctccctct  cctgctccc  tccaggcct  atctggcct  accgcgtgg  11820
catgcgccc  gtcccatcc  gggcgctgc  gaggctgac  agctccgtt  cccacagta  11880
ctcgacctc  gcctgacct  cggacccta  tccccctct  gtggggacg  cagcagcac  11940
tgctcctcc  gcgattctg  cttcagcca  gaccccctg  cattgggat  cagctcctt  12000
cccttcggg  ctggggtgc  gacatgagc  aggctcaag  ctgtgcagg  acataggct  12060
gtggccttg  gccttgggg  tcagccaca  cctgacaca  tgctcgacc  tgatagcat  12120
gggcccctg  cccagagtt  ctgtgccgt  tccaagggc  gtgcccttg  ccttggagc  12180
gccgtgcct  tgtcctgat  gcccaaatg  cagggttct  ctcggcttc  tggaccttg  12240
cgcttagtc  ccatcccgg  tttggctga  cctggctgg  gagctgcta  gctaaacct  12300
ctgcctccc  ataccagca  gaggttctg  gcctctgaa  cccctttcc  cacacctcc  12360
cctgctgct  ctgccccag  gtcttgacg  gagcattgg  ccctgagcc  agagaagct  12420
gaagcctgc  gaaaacagg  gcaaatggc  ttttataaa  tattttttt  aaataaagc  12480
ctgtgtgcc  gggtcttcc  tgagcaaca  ggagtgggg  gaggtggag  gatccctcc  12540
gcagagttc  gcctacagg  cacggactg  gggcactgg  ccaggccat  ggctccgcc  12600
cctccactg  cccaggagc  agtgtgtgc  tatctgggt  cgcctgtcc  accagcccc  12660
tcttgtgtc  gcgacagtg  gaatgagta  taatgggct  agtccgcat  gcactatac  12720
cggtgggac  cctgtaccc  ctgcacatg  gtgtgtgtg  atgtgtgcc  tgcagctgt  12780
cccaaggga  ctggcagcc  ccctccccc  tctgctcag  attaaccaa  ctgaccgtt  12840
acacagcat  aaaatctga  agccagcct  aggccgcgg  ccgctccca  gctctgccg  12900
ctcaggctg  gggcttgtg  aggccatgc  cgccccgcc  tggccagtc  cccgggcag  12960
agctggttg  cgcccgcct  ggctgcagc  gtccctgcc  gcctggtct  ccactgagg  13020
gccgtcaca  ccctgtact  agagctcct  agagtgagc  gcttctcaa  gctctgagc  13080
tggaacctc  ttccc  13095



<210> 4070
<211> 802
<212> PRT
<213> Homo sapiens
<308> CAA74200
<400> 4070

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
  1               5                  10                  15
Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
             20                  25                  30
Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
         35                  40                  45
Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
     50                  55                  60
His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
 65                  70                  75                  80
Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                 85                  90                  95
Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
             100                105                110
Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
         115                120                125
Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
     130                135                140
Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
 145                150                155                160
Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                 165                170                175
Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
             180                185                190
Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
         195                200                205
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
     210                215                220
Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
 225                230                235                240
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                 245                250                255
Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
             260                265                270
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
         275                280                285
Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
     290                295                300
Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
 305                310                315                320
Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                 325                330                335
Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
             340                345                350
Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
         355                360                365
Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
     370                375                380
Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
 385                390                395                400
Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                 405                410                415
Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
             420                425                430
Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
         435                440                445
Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
     450                455                460
Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
 465                470                475                480
Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                 485                490                495
Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
             500                505                510
Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
         515                520                525
Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
     530                535                540
Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
 545                550                555                560
Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                 565                570                575
Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
             580                585                590
Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
         595                600                605
Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
     610                615                620
Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
 625                630                635                640
Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                 645                650                655
Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
             660                665                670
Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
         675                680                685
Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
     690                695                700
Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
 705                710                715                720
Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                 725                730                735
Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
             740                745                750
Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
         755                760                765
Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
     770                775                780
Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
 785                790                795                800
Gln Thr 
                 805



<210> 4071
<211> 2648
<212> DNA
<213> Rattus norvegicus
<308> M91599
<400> 4071

catcaataa  gaggacccc  agaccctca  cagctcctc  agtgggcac  cctacctgc  60
gcaagcacc  tactggaca  acccccaac  catggagaa  aaactgcac  cggtacctg  120
cgggaacac  gtcaaattc  gctgtccag  tgcagggaa  cccatgccc  ccatccact  180
gctcaagaa  ggacaggcc  tccacgggg  gaatcgtat  ggaggcatt  ggctgcgtc  240
ccaacactg  agcctcgtg  tggagagcg  ggtgccctc  gaccgtggc  cgtacacgt  300
tcttgtgga  aactctctg  gtagcattc  ctacagcta  ctgctggat  tgctggagc  360
gtccccgca  cggcccatc  tgcaggcgg  actcccagc  aacaccacg  ctgtggttg  420
cagcaacgt  gagctgctg  gcaaggtgt  cagtgacgc  cagccgcac  tccagtggc  480
gaagcacat  gttatcaac  gcagcagtc  cggcgctga  ggtttcccc  acgtacaag  540
cctgaagac  acagacatc  atagctcag  ggtggaggt  ctgtatctg  ggaacgtgt  600
ggctgagga  gcaggggag  acacctgcc  ggcgggcaa  tccatcggc  tctcctacc  660
gtcagcgtg  ctcacagtg  tacccgcag  ggaagaaga  ctcgcgtgg  caacagcaa  720
atcggaggc  agatataca  atattatcc  atatgtcca  ggctcactg  ctttggttt  780
gctcctgct  ctggccggg  tgtatcacc  acaagcaat  cacggccac  actctcgac  840
gcctgtcac  gtacagaag  tgtcccggt  ccctttggc  cggcagttc  ccttggagt  900
gaggtcctc  ggcaagtca  gtttgtccc  ggtgcgagg  gtccggctc  cctccagtg  960
cccgccctt  ctcacgggc  ttgtgagtc  agacctacc  ctcgatcca  tttgggagt  1020
cccccggga  aggctggtg  tcggaaagc  cctgggtga  ggctgcttt  ggcaagtgg  1080
ttgtgcaga  gcccttggc  tggattcct  ccggccaga  caaaccagc  tcgtggctg  1140
gaagatgct  aaagacaat  cctccgaca  ggatttggc  gacctgatc  ctgagatgg  1200
gatgatgaa  ctaatcgga  gacacaaga  catcattaa  ctgctgggt  tctgcactc  1260
ggaagggcc  ctgtatgtg  ttgtggaat  tgcggccaa  ggaaacctt  gggaattcc  1320
ccgtgcccg  cgtccccca  gccctgatc  cagccctga  gggcctcgg  gcagcgaag  1380
accgctctc  ttcccggcc  tggtctcct  tgcctacca  gtggcccga  gcatgcagt  1440
tctggagtc  cggaagtgc  tccaccggg  cctggctgc  cgaaacgtg  tggtgaccg  1500
ggatgacgt  atgaagatc  ctgactttg  tctggcccg  ggtgtccac  acatcgact  1560
ctataagaa  accagcaat  gccgcctgc  agtcaagtg  atggctcct  aggcgttgt  1620
tgaccgtgt  tacacacac  agagtgacg  gtggtcctt  gggatcctg  tgtgggaaa  1680
cttcaccct  gggggctcc  cataccccg  catcccagt  gaggagctg  tctcactgc  1740
gcgagaggg  cacaggatg  agcggcccc  aaactgccc  tcagagctg  atgggctaa  1800
gagggagtg  tggcacgca  ctccttctc  gaggccgac  tttaagcag  tggtggaag  1860
tctggacaa  gtcctgctg  ctgtctctg  agagtacct  gacctccgc  tgacctttg  1920
accctattc  cccaacaat  gggatgcca  cagcacgtg  tcctccagc  actcggttt  1980
cagccacga  cctttgccc  tcgagccaa  ccccttccc  tttcctgag  cgcagacca  2040
atgagcctg  gaacgatgt  gcatgggct  gtaggcccg  ggccgtggg  ctccaacct  2100
tttcatcag  atttgacgt  ggcactgtc  tcaggcctc  gactcgagg  tactgctgg  2160
ccagatcct  tctctggcc  tgttttggg  aggcccatt  ttggtcttg  ggttcacag  2220
tgaggcctt  tgttccaaa  ttatgttcc  agctcagag  tcaactcct  gtctcaaga  2280
catggtcgt  cccttggac  catcctcaa  ggagcgaag  attaaggcc  tgacactta  2340
cctccaccc  aggggctct  cgggcctga  tgcaaatct  tggtcctaa  catttctag  2400
tccccaaac  acctagagg  ctcgggact  cactgcacc  ccgcccccg  agcccacaa  2460
cctcgccac  ctggtcccc  actccccac  gcttgttct  gcatcttgt  gaaggagcc  2520
cagctctgg  gtccttgag  gagggaagc  tgtggaaaa  acagaagaa  aaggcattt  2580
ataaattat  attattttt  aaaaaaaaa  aaaaaaatc  agaattctg  agaaggatc  2640
cgcgccat  2648



<210> 4072
<211> 650
<212> PRT
<213> Rattus norvegicus
<308> AAA41157
<400> 4072

Met Glu Lys Lys Leu His Ala Val Pro Ala Gly Asn Thr Val Lys Phe 
  1               5                  10                  15
Arg Cys Pro Ala Ala Gly Asn Pro Met Pro Thr Ile His Trp Leu Lys 
             20                  25                  30
Asn Gly Gln Ala Phe His Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu 
         35                  40                  45
Arg His Gln His Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp 
     50                  55                  60
Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn Ser Leu Gly Ser Ile Arg 
 65                  70                  75                  80
Tyr Ser Tyr Leu Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile 
                 85                  90                  95
Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala Val Val Gly Ser Asn 
             100                105                110
Val Glu Leu Leu Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln 
         115                120                125
Trp Leu Lys His Ile Val Ile Asn Gly Ser Ser Leu Gly Ala Asp Gly 
     130                135                140
Phe Pro Tyr Val Gln Val Leu Lys Thr Thr Asp Ile Asn Ser Ser Glu 
 145                150                155                160
Val Glu Val Leu Tyr Leu Arg Asn Val Ser Ala Glu Asp Ala Gly Glu 
                 165                170                175
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala 
             180                185                190
Trp Leu Thr Val Leu Pro Ala Glu Glu Glu Asp Leu Ala Trp Thr Thr 
         195                200                205
Ala Thr Ser Glu Ala Arg Tyr Thr Asp Ile Ile Leu Tyr Val His Gly 
     210                215                220
Ser Leu Ala Leu Val Leu Leu Leu Leu Leu Ala Gly Val Tyr His Arg 
 225                230                235                240
Gln Ala Ile His Gly His His Ser Arg Gln Pro Val Thr Val Gln Lys 
                 245                250                255
Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe Ser Leu Glu Ser Arg Ser 
             260                265                270
Ser Gly Lys Ser Ser Leu Ser Leu Val Arg Gly Val Arg Leu Ser Ser 
         275                280                285
Ser Gly Pro Pro Leu Leu Thr Gly Leu Val Ser Leu Asp Leu Pro Leu 
     290                295                300
Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg Leu Val Leu Gly Lys Pro 
 305                310                315                320
Leu Gly Glu Gly Cys Phe Gly Gln Val Val Cys Ala Glu Ala Leu Gly 
                 325                330                335
Met Asp Ser Ser Arg Pro Asp Gln Thr Ser Ile Val Ala Val Lys Met 
             340                345                350
Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ala Asp Leu Ile Ser Glu 
         355                360                365
Met Glu Met Met Lys Leu Ile Gly Arg His Lys Asn Ile Ile Asn Leu 
     370                375                380
Leu Gly Val Cys Thr Gln Glu Gly Pro Leu Tyr Val Ile Val Glu Tyr 
 385                390                395                400
Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro 
                 405                410                415
Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg Ser Ser Glu Gly Pro Leu 
             420                425                430
Ser Phe Pro Ala Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met 
         435                440                445
Gln Tyr Leu Glu Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala Arg 
     450                455                460
Asn Val Leu Val Thr Glu Asp Asp Val Met Lys Ile Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr Lys Lys Thr Ser Asn 
                 485                490                495
Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg 
             500                505                510
Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp 
         515                520                525
Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu 
     530                535                540
Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg Met Glu Arg Pro Pro 
 545                550                555                560
Asn Cys Pro Ser Glu Leu Tyr Gly Leu Met Arg Glu Cys Trp His Ala 
                 565                570                575
Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Ala Leu Asp 
             580                585                590
Lys Val Leu Leu Ala Val Ser Glu Glu Tyr Leu Asp Leu Arg Leu Thr 
         595                600                605
Phe Gly Pro Tyr Ser Pro Asn Asn Gly Asp Ala Ser Ser Thr Cys Ser 
     610                615                620
Ser Ser Asp Ser Val Phe Ser His Asp Pro Leu Pro Leu Glu Pro Ser 
 625                630                635                640
Pro Phe Pro Phe Pro Glu Ala Gln Thr Thr 
                 645                650



<210> 4073
<211> 3015
<212> DNA
<213> Homo sapiens
<308> NM_002011
<400> 4073

ccgaggagc  ctcgggctg  ctgcggacc  tgccgcgtg  aggggtcgc  gccggctgg  60
gctgggagt  aggcggcgg  ggagccagg  gaggaggag  caggaaggc  gttggtggg  120
agtccagct  gggtccctg  gagctgtga  aaggagatg  ggctgctgc  ggccctgtt  180
ggggtcctg  tgagtgtgc  tgggcctcc  gtcttgtcc  tggaggcct  tgaggaagt  240
gagcttgag  cctgcctgg  tcccagcct  gagcagcaa  agcaggagc  gacagtagc  300
cttgggcag  ctgtgcggc  gtgctgtgg  cgggctgag  gtggtggcc  ctggtacaa  360
gagggcagt  gcctggcac  tgctggccg  gtacggggc  ggaggggcc  cctagagat  420
gccagcttc  tacctgagg  tgctggccg  tacctctgc  tggcacgag  ctccatgat  480
gtcctgcag  atctcacct  gattacagg  gactccttg  cctccagca  cgatgatga  540
gaccccaag  cccataggg  cctctcgaa  aggcacagt  acccccagc  agcacccta  600
tggacacac  cccagcgca  ggagaagaa  ctgcatgca  tacctgcgg  gaacaccgt  660
aagttccgc  gtccagctg  aggcaaccc  acgcccacc  tccgctggc  taaggatgg  720
caggccttt  atggggaga  ccgcattgg  ggcattcgg  tgcgccatc  gcactggag  780
ctcgtgatg  agagcgtgg  gccctcgga  cgcggcaca  acacctgcc  ggtagagaa  840
gctgtgggc  gcatccgct  taactacct  ctagatgtg  tggagcggt  cccgcaccg  900
cccatcctg  aggccgggc  cccggccaa  accacagcc  tggtgggca  cgacgtgga  960
ctgctgtgc  aggtgtaca  cgatgccca  ccccacatc  agtggctga  gcacatcgt  1020
atcaacggc  gcagcttcg  agccgacgg  ttcccctat  tgcaagtcc  aaagactgc  1080
gacatcaat  gctcagagg  ggaggtcct  tacctgcgg  acgtgtcag  cgaggacgc  1140
ggcgagtac  cctgcctcg  aggcaattc  atcggcctc  cctaccagt  tgcctggct  1200
acggtgctg  cagaggagg  ccccacatg  accgcagca  cgcccgagg  caggtatac  1260
gacatcatc  tgtacgcgt  gggctccct  gccttggct  tgctcctgc  gctggccgg  1320
ctgtatcga  ggcaggcgc  ccacggccg  cacccccgc  cgcccgcca  tgtgcagaa  1380
ctctcccgc  tccctctgg  ccgacagtt  tccctggag  caggctctt  cggcaagtc  1440
agctcatcc  tggtacgag  cgtgcgtct  tcctccagc  gccccgcct  gctcgccgg  1500
ctcgtgagt  tagatctac  tctcgaccc  ctatgggag  tcccccggg  caggctggt  1560
cttgggaag  ccctaggcg  gggctgctt  ggccaggta  tacgtgcag  ggcctttgg  1620
atggaccct  cccggcctg  ccaagccag  actgtggcc  tcaagatgc  caaagacaa  1680
gcctctgac  aggacctgg  cgacctggt  tcggagatg  aggtgatga  gctgatcgg  1740
cgacacaag  acatcatca  cctgcttgg  gtctgcacc  aggaagggc  cctgtacgt  1800
atcgtggag  gcgccgcca  gggaaacct  cgggagttc  tgcgggccc  gcgcccccc  1860
ggccccgac  tcagccccg  cggtcctcg  agcagtgag  ggccgctct  cttcccagt  1920
ctggtctcc  gcgcctacc  ggtggcccg  ggcatgcag  atctggagt  ccggaagtg  1980
atccaccgg  acctggctg  ccgcaatgt  ctggtgact  aggacaatg  gatgaagat  2040
gctgacttt  ggctggccc  cggcgtcca  cacattgac  actataaga  aaccagcaa  2100
ggccgcctg  ctgtgaagt  gatggcgcc  gaggccttg  ttgaccggg  gtacacaca  2160
cagagtgac  tgtggtctt  tgggatcct  ctatgggag  tcttcaccc  cgggggctc  2220
ccgtatcct  gcatcccgg  ggaggagct  ttctcgctg  tgcgggagg  acatcggat  2280
gaccgaccc  cacactgcc  cccagagct  tacgggctg  tgcgtgagt  ctggcacgc  2340
gcgccctcc  agaggccta  cttcaagca  ctggtggag  cgctggaca  ggtcctgct  2400
gccgtctct  aggagtacc  cgacctccg  ctgaccttc  gaccctatt  cccctctgg  2460
ggggacgcc  gcagcacct  ctcctccag  gattctgtc  tcagccacg  ccccctgcc  2520
ttgggatcc  gctccttcc  cttcgggtc  ggggtgcag  catgagcaa  gctcaaggc  2580
gtgcaggca  ataggctgg  ggccttggg  cttggggct  agccacagc  tgacacagt  2640
ctcgacctt  atagcatgg  gcccctggc  cagagttgc  gtgccgtgt  caagggccg  2700
gcccttgcc  ttggagctg  cgtgcctgt  tcctgatgg  ccaaatgtc  gggttctgc  2760
cggcttctt  gaccatggc  cttagtccc  atcccgggt  tggctgagc  tggctggag  2820
gctgctatg  taaacctcc  gcctcccaa  accagcagg  ggttctggg  ctctgaacc  2880
cctttcccc  cacctcccc  tgctgctgc  gccccagcg  cttgacggg  gcattggcc  2940
ctgagccca  agaagctgg  agcctgccg  aaacaggag  aaatggcgt  ttataaatt  3000
tttttttga  ataaa  3015



<210> 4074
<211> 802
<212> PRT
<213> Homo sapiens
<308> P22455
<400> 4074

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
  1               5                  10                  15
Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
             20                  25                  30
Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
         35                  40                  45
Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
     50                  55                  60
His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
 65                  70                  75                  80
Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                 85                  90                  95
Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
             100                105                110
Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
         115                120                125
Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
     130                135                140
Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
 145                150                155                160
Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                 165                170                175
Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
             180                185                190
Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
         195                200                205
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
     210                215                220
Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
 225                230                235                240
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                 245                250                255
Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
             260                265                270
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
         275                280                285
Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
     290                295                300
Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
 305                310                315                320
Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                 325                330                335
Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
             340                345                350
Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
         355                360                365
Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
     370                375                380
Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
 385                390                395                400
Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                 405                410                415
Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
             420                425                430
Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
         435                440                445
Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
     450                455                460
Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
 465                470                475                480
Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                 485                490                495
Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
             500                505                510
Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
         515                520                525
Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
     530                535                540
Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
 545                550                555                560
Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                 565                570                575
Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
             580                585                590
Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
         595                600                605
Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
     610                615                620
Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
 625                630                635                640
Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                 645                650                655
Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
             660                665                670
Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
         675                680                685
Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
     690                695                700
Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
 705                710                715                720
Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                 725                730                735
Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
             740                745                750
Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
         755                760                765
Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
     770                775                780
Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
 785                790                795                800
Gln Thr 
                 805



<210> 4075
<211> 2648
<212> DNA
<213> Rattus norvegicus
<308> M91599
<400> 4075

catcaataa  gaggacccc  agaccctca  cagctcctc  agtgggcac  cctacctgc  60
gcaagcacc  tactggaca  acccccaac  catggagaa  aaactgcac  cggtacctg  120
cgggaacac  gtcaaattc  gctgtccag  tgcagggaa  cccatgccc  ccatccact  180
gctcaagaa  ggacaggcc  tccacgggg  gaatcgtat  ggaggcatt  ggctgcgtc  240
ccaacactg  agcctcgtg  tggagagcg  ggtgccctc  gaccgtggc  cgtacacgt  300
tcttgtgga  aactctctg  gtagcattc  ctacagcta  ctgctggat  tgctggagc  360
gtccccgca  cggcccatc  tgcaggcgg  actcccagc  aacaccacg  ctgtggttg  420
cagcaacgt  gagctgctg  gcaaggtgt  cagtgacgc  cagccgcac  tccagtggc  480
gaagcacat  gttatcaac  gcagcagtc  cggcgctga  ggtttcccc  acgtacaag  540
cctgaagac  acagacatc  atagctcag  ggtggaggt  ctgtatctg  ggaacgtgt  600
ggctgagga  gcaggggag  acacctgcc  ggcgggcaa  tccatcggc  tctcctacc  660
gtcagcgtg  ctcacagtg  tacccgcag  ggaagaaga  ctcgcgtgg  caacagcaa  720
atcggaggc  agatataca  atattatcc  atatgtcca  ggctcactg  ctttggttt  780
gctcctgct  ctggccggg  tgtatcacc  acaagcaat  cacggccac  actctcgac  840
gcctgtcac  gtacagaag  tgtcccggt  ccctttggc  cggcagttc  ccttggagt  900
gaggtcctc  ggcaagtca  gtttgtccc  ggtgcgagg  gtccggctc  cctccagtg  960
cccgccctt  ctcacgggc  ttgtgagtc  agacctacc  ctcgatcca  tttgggagt  1020
cccccggga  aggctggtg  tcggaaagc  cctgggtga  ggctgcttt  ggcaagtgg  1080
ttgtgcaga  gcccttggc  tggattcct  ccggccaga  caaaccagc  tcgtggctg  1140
gaagatgct  aaagacaat  cctccgaca  ggatttggc  gacctgatc  ctgagatgg  1200
gatgatgaa  ctaatcgga  gacacaaga  catcattaa  ctgctgggt  tctgcactc  1260
ggaagggcc  ctgtatgtg  ttgtggaat  tgcggccaa  ggaaacctt  gggaattcc  1320
ccgtgcccg  cgtccccca  gccctgatc  cagccctga  gggcctcgg  gcagcgaag  1380
accgctctc  ttcccggcc  tggtctcct  tgcctacca  gtggcccga  gcatgcagt  1440
tctggagtc  cggaagtgc  tccaccggg  cctggctgc  cgaaacgtg  tggtgaccg  1500
ggatgacgt  atgaagatc  ctgactttg  tctggcccg  ggtgtccac  acatcgact  1560
ctataagaa  accagcaat  gccgcctgc  agtcaagtg  atggctcct  aggcgttgt  1620
tgaccgtgt  tacacacac  agagtgacg  gtggtcctt  gggatcctg  tgtgggaaa  1680
cttcaccct  gggggctcc  cataccccg  catcccagt  gaggagctg  tctcactgc  1740
gcgagaggg  cacaggatg  agcggcccc  aaactgccc  tcagagctg  atgggctaa  1800
gagggagtg  tggcacgca  ctccttctc  gaggccgac  tttaagcag  tggtggaag  1860
tctggacaa  gtcctgctg  ctgtctctg  agagtacct  gacctccgc  tgacctttg  1920
accctattc  cccaacaat  gggatgcca  cagcacgtg  tcctccagc  actcggttt  1980
cagccacga  cctttgccc  tcgagccaa  ccccttccc  tttcctgag  cgcagacca  2040
atgagcctg  gaacgatgt  gcatgggct  gtaggcccg  ggccgtggg  ctccaacct  2100
tttcatcag  atttgacgt  ggcactgtc  tcaggcctc  gactcgagg  tactgctgg  2160
ccagatcct  tctctggcc  tgttttggg  aggcccatt  ttggtcttg  ggttcacag  2220
tgaggcctt  tgttccaaa  ttatgttcc  agctcagag  tcaactcct  gtctcaaga  2280
catggtcgt  cccttggac  catcctcaa  ggagcgaag  attaaggcc  tgacactta  2340
cctccaccc  aggggctct  cgggcctga  tgcaaatct  tggtcctaa  catttctag  2400
tccccaaac  acctagagg  ctcgggact  cactgcacc  ccgcccccg  agcccacaa  2460
cctcgccac  ctggtcccc  actccccac  gcttgttct  gcatcttgt  gaaggagcc  2520
cagctctgg  gtccttgag  gagggaagc  tgtggaaaa  acagaagaa  aaggcattt  2580
ataaattat  attattttt  aaaaaaaaa  aaaaaaatc  agaattctg  agaaggatc  2640
cgcgccat  2648



<210> 4076
<211> 650
<212> PRT
<213> Rattus norvegicus
<308> AAA41157
<400> 4076

Met Glu Lys Lys Leu His Ala Val Pro Ala Gly Asn Thr Val Lys Phe 
  1               5                  10                  15
Arg Cys Pro Ala Ala Gly Asn Pro Met Pro Thr Ile His Trp Leu Lys 
             20                  25                  30
Asn Gly Gln Ala Phe His Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu 
         35                  40                  45
Arg His Gln His Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp 
     50                  55                  60
Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn Ser Leu Gly Ser Ile Arg 
 65                  70                  75                  80
Tyr Ser Tyr Leu Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile 
                 85                  90                  95
Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala Val Val Gly Ser Asn 
             100                105                110
Val Glu Leu Leu Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln 
         115                120                125
Trp Leu Lys His Ile Val Ile Asn Gly Ser Ser Leu Gly Ala Asp Gly 
     130                135                140
Phe Pro Tyr Val Gln Val Leu Lys Thr Thr Asp Ile Asn Ser Ser Glu 
 145                150                155                160
Val Glu Val Leu Tyr Leu Arg Asn Val Ser Ala Glu Asp Ala Gly Glu 
                 165                170                175
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala 
             180                185                190
Trp Leu Thr Val Leu Pro Ala Glu Glu Glu Asp Leu Ala Trp Thr Thr 
         195                200                205
Ala Thr Ser Glu Ala Arg Tyr Thr Asp Ile Ile Leu Tyr Val His Gly 
     210                215                220
Ser Leu Ala Leu Val Leu Leu Leu Leu Leu Ala Gly Val Tyr His Arg 
 225                230                235                240
Gln Ala Ile His Gly His His Ser Arg Gln Pro Val Thr Val Gln Lys 
                 245                250                255
Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe Ser Leu Glu Ser Arg Ser 
             260                265                270
Ser Gly Lys Ser Ser Leu Ser Leu Val Arg Gly Val Arg Leu Ser Ser 
         275                280                285
Ser Gly Pro Pro Leu Leu Thr Gly Leu Val Ser Leu Asp Leu Pro Leu 
     290                295                300
Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg Leu Val Leu Gly Lys Pro 
 305                310                315                320
Leu Gly Glu Gly Cys Phe Gly Gln Val Val Cys Ala Glu Ala Leu Gly 
                 325                330                335
Met Asp Ser Ser Arg Pro Asp Gln Thr Ser Ile Val Ala Val Lys Met 
             340                345                350
Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ala Asp Leu Ile Ser Glu 
         355                360                365
Met Glu Met Met Lys Leu Ile Gly Arg His Lys Asn Ile Ile Asn Leu 
     370                375                380
Leu Gly Val Cys Thr Gln Glu Gly Pro Leu Tyr Val Ile Val Glu Tyr 
 385                390                395                400
Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro 
                 405                410                415
Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg Ser Ser Glu Gly Pro Leu 
             420                425                430
Ser Phe Pro Ala Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met 
         435                440                445
Gln Tyr Leu Glu Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala Arg 
     450                455                460
Asn Val Leu Val Thr Glu Asp Asp Val Met Lys Ile Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr Lys Lys Thr Ser Asn 
                 485                490                495
Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg 
             500                505                510
Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp 
         515                520                525
Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu 
     530                535                540
Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg Met Glu Arg Pro Pro 
 545                550                555                560
Asn Cys Pro Ser Glu Leu Tyr Gly Leu Met Arg Glu Cys Trp His Ala 
                 565                570                575
Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Ala Leu Asp 
             580                585                590
Lys Val Leu Leu Ala Val Ser Glu Glu Tyr Leu Asp Leu Arg Leu Thr 
         595                600                605
Phe Gly Pro Tyr Ser Pro Asn Asn Gly Asp Ala Ser Ser Thr Cys Ser 
     610                615                620
Ser Ser Asp Ser Val Phe Ser His Asp Pro Leu Pro Leu Glu Pro Ser 
 625                630                635                640
Pro Phe Pro Phe Pro Glu Ala Gln Thr Thr 
                 645                650



<210> 4077
<211> 13095
<212> DNA
<213> Homo sapiens
<308> Y13901
<400> 4077

gaattcaag  tgtcctcct  cctcagtct  ctagtaact  gaactacag  cacccgtca  60
tgtgcccgg  cattccaca  ctatttaca  aattaactg  tcagttaca  ttctggcaa  120
cgtgctgaa  aaataacag  tcctaaata  ttacagcta  tattacaaa  caagcgctg  180
atgccaggc  tacacatac  gctaacatg  ctacttttt  caacaacct  ttgtgggtg  240
gactatcat  tgcctgttt  actgaaagg  cagtgaaga  tgaggcctt  tgtgatggt  300
ctgagagct  ggcctatga  gtccagccc  gtagtctgt  ctctgaacc  cttcaccct  360
tttctttct  catcctcac  gtagagacg  catctaaga  gagcttgca  gtccagagg  420
cttcctgaa  gaagtgagc  gagaataat  tgaaattaa  cagaccaag  ggcattcca  480
gaagagaga  tggtacgtg  aactgccca  gagtagcag  gtgggagcc  ggaggcgtg  540
gtcatggca  tctatgtat  aagagctat  ggaatctat  ggaaaattt  agggagtgg  600
tgacacagt  agatttgtg  tgtaagtat  actccgcag  ttgcgcagg  aacaaatga  660
ggagcagaa  gaaggggtt  tcctgtccg  tgcacggca  tgcgcagaa  acaggggag  720
caggcattc  ctgaagggt  aaaagcaag  agtagagct  ggtagtaga  tagaattta  780
gagcctggc  tggggcctg  gtggggcga  agaggcgga  ctgaatggg  tgtgtatag  840
ggggttgcg  gtaggggtg  gtgtatagg  tggggcggg  tcccgggag  gggctgact  900
ggtcggggg  ggggctctc  aggtgggcg  ggatcttgg  cacccctgg  cacacctct  960
tccggctcg  gctggtcta  gcggggcgg  cccgagggg  tgtggcagg  ggtgggcgg  1020
cccgggtgg  ggggggggg  gtggaagga  gggcgggcc  gagcaggag  gggcgggcc  1080
gaggggcgg  gcgggacag  aggtgggcc  ctcgcggca  gccgccgtc  cgggtacat  1140
cctcgctcc  ggccgagga  cgctcgggc  gtctgcgga  cctgccgcg  gcaggggtc  1200
cggccggct  gagctggga  tgaggcggc  gaggagcca  gtgaggagg  gccaggtga  1260
caggaccct  tgctgggcg  ggagtcacg  aggctcgag  tgagccgga  cccttgtgg  1320
cccggctgc  ctcccagcc  ccagggggc  agaggcggc  gggctacgg  gactgcccc  1380
cccggcgca  gggacctgg  cgtccgccg  gcggcaggg  gtggagggg  cggtaaatc  1440
gtaacccgc  gtgcacaca  ggccttttg  cccgctccg  ccaaagagc  ccccggccg  1500
ggagctggt  actcattgc  caccgaggc  ggggcaggc  ggccctgtg  agctaccct  1560
gggacccat  gattcgcac  tccccccag  ctggcccgg  aagggtggg  gaggacaag  1620
gcgcttgtc  ctgcggctg  cttcgcgcc  gcggcagag  tgagggacc  gaggccccg  1680
aaagttcag  cacttagtg  ccgggggcc  ccagcgcga  tgcgggagg  tgaaggaga  1740
cccaggact  tctgatgcc  aaggcaggc  ctccattcc  acgtggggg  tggtcggtc  1800
gcggtcagc  gccacgggt  actcgacta  ggactctga  atcagggca  cctggggta  1860
gaataaact  cccgggcct  cccacccac  cccagccca  gctgtgtac  caaagagct  1920
ccctccctg  caagccgag  ttggtaggg  gttttacca  ggaggatcc  actggattc  1980
agagttgag  tgggccaga  acagcagta  ctgagtcag  tagagaaga  caatgaggg  2040
cacagaggg  tgggcaaga  agcacatgt  cccagtttt  aaagccaat  gcttcagcg  2100
tcctgaagg  gcagacggt  tgaccaaag  gataggcag  ggcagagag  gagccctag  2160
atgttgagc  ggatcctgc  gggcacagg  agccattaa  ggcttgcaa  ctggggggc  2220
tgacatggc  gacttgcag  tttttttgt  tgttttttt  ttttatttt  tttttttat  2280
ttgtttttt  tgagacgga  tctcactct  tcgcccagg  tggagtgca  tggcgcgat  2340
tcggctcac  gcaagctcc  cctcccggg  tcgcgccat  ctcctgcct  agcctcccg  2400
gtagctggg  ctacaggcg  ccgccaccg  gcccggcta  ttttttgta  ttttagtag  2460
gacggggtt  caccgtgtt  gccaggatg  tctcgatct  ctgacctcg  gatccgccc  2520
cctcggcct  ccaaagtgc  gggattaca  gtgtgaacc  tcgcgccca  ccgacttgt  2580
gttttttaa  actctgctg  aagatgaag  ttgaagagc  gagggagag  atgtttcca  2640
aggcccatg  aagagatgg  catgacctg  cttgagaag  ggcagggga  gccagatgg  2700
ctggaagtg  agtggcagt  accaaggag  aggaggtgt  ataggcttc  cacgcaggg  2760
agatccaga  acaccagtg  cacccatag  cccctagga  tgcagtggt  acccgattc  2820
tttgtccca  ctgagactc  gttctgagt  ttctatttt  gggaacaga  gcgtccttg  2880
tagcatttg  aagaggata  ccagctggg  tgtgtgtac  tcacagcct  acagtaaca  2940
catccgaac  agaggtgac  ggctaaggg  agacccagg  caacaggtt  accgttcta  3000
ggccgggca  agggaggag  acattccaa  actctgtgt  cccagtgcc  acgcacgtt  3060
tctctttta  cctcaaaac  gtcctatga  gatataagc  agagagaga  agagacaag  3120
aattacaag  tggtgagag  caggatttg  acttggctc  ggcagatgg  aaattaggg  3180
ctgtattct  tacaaaacc  tgtgtgcct  agatggagt  ggtgcataa  aagcagagg  3240
atccagggt  gcggtcctg  ttgccacgg  aggggccgc  ttgtcagtt  tgaccaccc  3300
gccctggaa  tgtcagtaa  gctgtaagg  gtggggatc  gatcagatg  catccagat  3360
ctgaagttt  accttgtgt  atttttcac  ttctttttt  gctcttctg  aatcaattc  3420
tttatttag  aaaaaagaa  ttatgtgtg  cgagagcat  cagaagata  gtctccgtt  3480
tctgcttcc  tccaaaaaa  aatcccaaa  ctgctttct  tgaacgtgt  ccagggtcc  3540
agcaggact  agggagagc  ggaagccca  cccagaccc  ttgcacaac  taccgtggg  3600
aggccttag  ctctggcta  tacagagct  gttccagtc  gcactgcca  agcctggcc  3660
gggacttgg  cacatctgc  ggccacttc  tgtctcagt  tccttatct  caaaataag  3720
gaaaagccc  cacaaaggt  cacgtgtag  aggagctct  ttccctccc  attttagga  3780
ggcagttgg  gggaagtcc  gcttgggtc  ctgagagct  tgagaagga  atgcggctg  3840
tgctggccc  gttggggat  ctgctgagt  tgcctgggc  tccagtctt  tccctggag  3900
cctctgagg  agtggagct  ggtatggct  ctgaggtgg  agagggtgg  aggggtggg  3960
agagtgggc  ccaggaggg  gctgctggg  tgagcaaag  tggaaagga  ccttgccca  4020
gccctgaga  ggtggcggc  gggcagggc  caaccactg  gactcagtc  gtgcctggc  4080
tccagcaag  attcatcta  cactgtgtc  gcgagagag  actggcctt  cagggcgca  4140
ggccctaag  tgggctgca  agctggtgg  gagctcctt  cctgggtgt  tgtgcgtgt  4200
tgtgtgtgt  ctgtgcact  ggtgtgtga  ctaggaggt  caggcagca  gtgtggtat  4260
agcattatg  gggtgatat  ccccggtgc  gcatgaccc  gtatgtggc  ccaacagca  4320
gtgccttgt  tgtgtgtgt  tccgtatgt  tgtgtgtgt  tgcgtgtgt  tgtgtgtgt  4380
tgtgtgtct  ggccactgt  atgtgcact  aatgctgtg  gtgtgacat  ccccaagag  4440
gtggcattt  ccctgggtg  ggcatccgc  gcatgtggc  gtgtgggtg  caaggagtg  4500
tggctcctt  agcatgcgt  gcgaagtgc  tgtgccctg  atgtgcggt  tgttctctg  4560
acacaggag  ctgcctcag  tggggctgc  gggtctgct  acctctccc  ctgcccaca  4620
agccctgcc  ggctcccag  ctggagcag  aagagcagg  gctgacagt  gcccttggg  4680
agcctgtgc  gctgtgctg  gggcgggct  agcgtggtg  ccactggta  aaggagggc  4740
gtcgcctgg  acctgctgg  cgtgtacgg  gctggaggg  ccgcctaga  attgccagc  4800
tcctacctg  ggatgctgg  cgctacctc  gcctggcac  aggctccat  atcgtcctg  4860
agaatctca  cttgattac  ggtggtaag  gactctagc  gggagtgaa  ggatgccag  4920
ggagacaga  ctgcccccc  tggacctta  atgctccct  tgtccctga  gtagactcc  4980
tgacctcca  caacgatga  gaggacccc  agtcccata  ggacctctc  aataggcac  5040
gttaccccc  gcaaggtca  taggtctcc  aggacttgt  tcccgctgc  gctcatctg  5100
tcactgaga  gaggaggcc  gtgtgggaa  acacggtca  tctaggggc  ttcccctgc  5160
ctccagcac  ctactggac  cacccccag  gcatggaga  gaaactgca  gcagtacct  5220
cggggaaca  cgtcaagtt  cgctgtcca  ctgcaggca  ccccacgcc  accatccgc  5280
ggcttaagg  tggacaggc  tttcatggg  agaaccgca  tggaggcat  cgggtgagt  5340
tctgggttc  aagaccgtc  gctccccca  tttcattcc  tcatcagtc  cctcatacc  5400
acaagcata  ctataaatc  atcgaatga  tgaagcgat  gcggggccc  ggaaggagc  5460
ctggactgt  gacctgggc  gctctggtt  cccttctgc  actctctgg  aagtgactt  5520
acctctcag  ctcagcaac  ccctttgta  agggagaag  atcactgac  ggttggtct  5580
cataagcct  agcatctca  cgtcttgat  agaccctgc  gggtcggct  catgctgtc  5640
tgaggcaac  gagcctcag  gaaggcaag  gttggctca  agtagcaca  ctagggaga  5700
ggagagcta  aattccaaa  gctcaaacc  aaggctcaa  cgccctggg  agcctactc  5760
tttgtgcca  agtccttgg  ctgggcctg  tgttctcag  gcctagaga  cttgacaag  5820
gccctgtgg  caggatgag  atctagcct  ctggtcctc  ggccccctt  gtggacatg  5880
tccggtggt  ccggacact  tctctgcct  cagctgcgc  atcagcact  gagtctcgt  5940
atggagagc  tggtgccct  ggaccgcgg  acatacacc  gcctggtag  gaacgctgt  6000
ggcagcatc  gctataact  cctgctaga  gtgctgggt  agcgcgggg  tgggaacag  6060
ggaggcctg  cccattttg  gctcagttg  gccctcttg  tggggtcta  tctggcagg  6120
aggatggac  cagatgagt  aggcagctt  gtgagcagg  gggtcaggg  aaagcacag  6180
ggttagtgt  gggctggag  agcagaggt  tgccaagag  aaaaacaag  aggacatcc  6240
ggcagaggg  gcagcccga  cggagggcc  gagtataac  aacgccctg  acttgcagg  6300
cagcatatt  gtagggcgt  gcgtttata  ggggagcca  gtggtggag  gttttgaat  6360
ctaggctga  atgttgtcc  tgacccgaa  caataggga  ccagggaag  tttaagcag  6420
gtaagcagg  gacagacaa  aagctgcag  aaggtccct  ccttgaact  gaggaaggc  6480
ggagggagg  aaacagggt  cttctatgg  tgccagtgg  cagggttga  tgtctcgcc  6540
ggtccccag  gcggtcccc  caccggccc  tcctgcagg  cgggctccc  gccaacacc  6600
cagccgtgg  gggcagcga  gtggagctg  tgtgcaagg  gtacagcga  gcccagccc  6660
acatccagt  gctgaagca  atcgtcatc  acggcagca  cttcggagc  gacggtttc  6720
cctatgtgc  agtcctaaa  gtaaaaggt  caccctgct  cagcctggg  cccattctt  6780
tcccacctt  ggttggggg  ctccccagc  tccctgttg  ccacagtgt  gccccaggc  6840
ctgctgtga  cccagagca  gtcccccac  ccagactgc  gacatcaat  gctcagagg  6900
ggaggtcct  tacctgcgg  acgtgtcag  cgaggacgc  ggcgagtac  cctgcctcg  6960
aggcaattc  atcggcctc  cctaccagt  tgcctggct  acggtgctg  caggtgagc  7020
cctgaaggg  caggagatg  tgcgagatg  ccctctggg  cagcagtgg  ggctgtggc  7080
tgttgggtg  tcagtctct  ttggcctgt  gggtctggc  tggggggca  tgtgtggat  7140
tgtgggttt  agctgtatg  cagcccctc  gtgcctctc  acacgtggc  gtccatgtg  7200
ccgtctgct  aggtgtggg  gcctgggac  gggcataac  acagcttcc  ccgtgtgtg  7260
ccccacata  gttgggagc  gggagggac  gagttaggg  gcacggggc  gccagtctc  7320
ccactgacc  gtttgtctg  ctgtgtgtg  ccatgtgcg  gggcagagg  ggaccccac  7380
tggaccgca  cagcgcccg  ggccaggta  acggacatc  tcctgtacg  gtcgggctc  7440
ctggccttg  ctgtgctcc  gctgctggc  gggctgtat  gagggcagg  gctccacgg  7500
cggcacccc  gcccgcccg  cactgtgca  aagctctcc  gcttccctc  ggcccgaca  7560
gtactgggc  catccccca  ctcacatgt  acagcctga  tccagcagg  agaaccaag  7620
ctcccactt  gcagttctc  ctggagtca  gctcttccg  caagtcaag  tcatccctg  7680
tacgaggcg  gcgtctctc  tccagcggc  ccgccttgc  cgccggcct  gtgagtcta  7740
atctacctc  cgacccact  tgggagttc  cccgggaca  gtgcgctga  ctgtgtggg  7800
gcagggacg  gggcgccgg  ttgcagccc  ccctccgca  gagtgactc  gaggtctga  7860
gctggactt  ctccatctc  aggctggtg  ttgggaagc  cctaggcga  ggctgcttt  7920
gccaggtag  acgtgcaga  gcctttggc  tggaccctg  ccggcctga  caagccagc  7980
ctgtggccg  caagatgct  aaaggtgag  gtggcccgg  gtggtggct  acacctgta  8040
cgccagcac  ttaggaggc  gagggtggg  ggatcgctt  aatccagga  ttcgaggcc  8100
gcctgggca  catggcaag  cttcatctc  acaaaaaaa  aataagaaa  ttagttggg  8160
gtggtggtg  gtgccttta  tctcagtta  tagggaggc  gaggcagga  gatcccttg  8220
atccaggag  tggaggttg  agggagcca  gatcacgcc  ctgtattcc  gcctgggca  8280
cacagtgag  ccctatctg  aaaaataaa  aaataaata  aaataaaag  tgaacgtgg  8340
agcctggag  aggtgctat  gcattggga  taatagaag  ggctcacgg  gccaccagg  8400
gagccctgg  gctgggaga  gctgtggga  cccaccctt  aacctgcaa  tcacctctg  8460
tcctgaccc  ggcaagtga  ttctgagcc  cagttttcc  ttgtgtcat  tggggtaga  8520
aacagtccc  actcccagc  caaggattg  ggaaagtgc  tggctcata  tcagggctc  8580
ataaatctt  accactggg  tgatgatga  gagaagaat  tggtgtgac  ggcttgata  8640
cctgtgtca  cattagtct  tgtcagctt  gacttcaca  ctctttgtc  gcctcacag  8700
ccctctacc  ccttcctta  ggttccccc  agacacacc  tcagcctcc  ttggaccct  8760
cctaggtct  ccccccacg  ccactgctg  aggaggaca  cccttctgc  tgcacccag  8820
cccagcccc  gggtgctct  gctgggcac  cctgcaccc  acccatcag  gcctctcct  8880
gcagttccc  agccccctc  gcaagaatg  cctccactg  tcttctgct  ctcccctcc  8940
ctctacaca  ctggggcca  ctggtgctc  ctgggaggc  gggattgag  aatgcacat  9000
gtgtcattg  cccagggcc  caggtcagc  ccaggggct  agccagaga  gccaaagca  9060
ccttcttcc  aagctcccc  gctgcaccc  gcctgccgc  agctccctg  attcccagg  9120
cagttggaa  ccaggccct  gtcaaacag  ccccagggc  ccagcctgc  ttccgcacc  9180
agaagctct  accccatgc  gggactacc  ctgacccct  cagcggcag  ttccttcct  9240
ccttcctgc  ccgagctct  cccctctct  ctgtgtcct  ggcctgccc  ctggaaggc  9300
tgcctctta  atccttgat  cagttgcat  cttgcaact  ctgtgacag  cagggtgtg  9360
cccactgct  tgtttccca  aagacgaac  tgaggttca  agacgctag  agacttttt  9420
aaggccaca  agcctagca  ggattcagc  ctagaccta  gtagccctg  tccagtgct  9480
cttgtcctg  acctgcctc  gcatgctcc  tcgtgcagt  ggagggcag  ctctcaccc  9540
gtctgctgc  cttacagac  acgcctctg  caaggacct  gccgacctg  tctcggaga  9600
ggaggtgat  aagctgatc  gccgacaca  gaacatcat  aacctgctt  gtgtctgca  9660
ccaggaagg  ggggccgag  cggggctgg  tgcacgggc  gttagggtg  agagccaaa  9720
ctttggcag  ctctccacg  tccctccac  ccctctgca  ggcccctgt  cgtgatcgt  9780
gagtgcgcc  ccaagggaa  cctgcggga  ttcctgcgg  cccggcgcc  cccaggccc  9840
gacctcagc  ccgacggtc  tcggagcag  gaggggccg  tctccttcc  agtcctggt  9900
tcctgcgcc  accaggtgg  ccgaggcat  cagtatctg  agtcccgga  ggtataggc  9960
ctagggctc  gagcccctc  cagtctctc  agctccact  tcaggcctg  ggcattcaa  10020
gtcccgact  ctccctctc  gctcttttt  atgacccca  ctcagtgtc  ccaggcatt  10080
acgctttcc  gcattcccc  ctcgttcct  acccttccc  agaggggag  ggggacgca  10140
gagaaggca  tccccgttt  taaaccttg  cctcctcct  tgtaaagtg  gtggagggc  10200
cctgccccc  ggcctgctg  ggggtggtg  gtgctcaac  ccaggccag  tgtcctgag  10260
cacccaagc  cccgctccc  gcagtgtat  caccgggac  tggctgccc  caatgtgct  10320
gtgactgag  acaatgtga  gaagattgc  gactttggg  tggcccgcg  cgtccacca  10380
attgactac  ataagaaaa  cagcaacgt  agggagatg  ggcagaact  gatgggggt  10440
gaggggcac  gggcccggg  tggcaggca  gaggacctg  gggactctg  actgaggcc  10500
tctctcccc  ccagggccg  ctgcctgtg  agtggatgg  gcccgaggc  ttgtttgac  10560
gggtgtaca  acaccagag  gacgtgtga  tcctgccgg  ggtcactgt  ctaccccac  10620
aaaagggca  ggcactgcc  aaagtcacg  ggccccagg  gtcatgcgc  cgagggctc  10680
ttcagattt  gtctgggac  cgagtgggc  cagactcca  gaggagccc  ttccccaac  10740
gctgtggtg  gtcatgtct  tggggtccc  cgtcctagc  ccggtcgta  ggagggcgc  10800
gagccacac  gagccctgg  cctgcctcc  ggtggtctt  tgggatcct  ctatgggag  10860
tcttcaccc  cgggggctc  ccgtatcct  gcatcccgg  ggaggagct  ttctcgctg  10920
tgcgggagg  acatcggat  gaccgaccc  cacactgcc  cccagagct  tgaggcctc  10980
ccctgccct  gaccccact  tccagtcct  ctcctcctc  gccctgacc  tggcctcag  11040
gtgtgtccc  gccagaagg  caacactaa  aacaactcc  cgtcctcct  ctcctcttc  11100
tcttcctcc  cctcctctt  ctcctcctc  tcttcctcc  cctcctctt  ctcctcctc  11160
tcctcctcc  cctcttcct  ctcctcctc  tcctcctcc  cctcttcct  ctcctcctc  11220
tcctcctcc  cctcttcct  ctcctcctc  tcctcctcc  cctcctcct  ctcctcctc  11280
tcttcctcc  cctcctctt  ctcctcctc  tcctcctcc  cctcctcct  ctcctcttc  11340
tcctcctcc  cttcctcct  ctcctcctc  tcctcctcc  cttcctcct  ctcctcttc  11400
tcctcctcc  cttcctcct  ctcctcctg  tcctcttcc  cctcctcct  ttcctcctc  11460
tcctcctcc  cctcttcct  ctcctcagc  tagtggagt  tcctggcct  gcttctact  11520
atgaccctc  tatccctca  caaactccc  accaaactc  tccccaccc  gagaacccc  11580
ggtcctccc  ttcctcctg  aggcctgag  ctccctgtg  ccctccgcc  cacctctcg  11640
aggtacggg  tgatgcgtg  gtgctggca  gcagcgccc  cccagaggc  taccttcaa  11700
cagctggtg  aggcgctgg  caaggtcct  ctggccgtc  ctgaggagg  acagcccct  11760
ccacccacc  cctccctct  cctgctccc  tccaggcct  atctggcct  accgcgtgg  11820
catgcgccc  gtcccatcc  gggcgctgc  gaggctgac  agctccgtt  cccacagta  11880
ctcgacctc  gcctgacct  cggacccta  tccccctct  gtggggacg  cagcagcac  11940
tgctcctcc  gcgattctg  cttcagcca  gaccccctg  cattgggat  cagctcctt  12000
cccttcggg  ctggggtgc  gacatgagc  aggctcaag  ctgtgcagg  acataggct  12060
gtggccttg  gccttgggg  tcagccaca  cctgacaca  tgctcgacc  tgatagcat  12120
gggcccctg  cccagagtt  ctgtgccgt  tccaagggc  gtgcccttg  ccttggagc  12180
gccgtgcct  tgtcctgat  gcccaaatg  cagggttct  ctcggcttc  tggaccttg  12240
cgcttagtc  ccatcccgg  tttggctga  cctggctgg  gagctgcta  gctaaacct  12300
ctgcctccc  ataccagca  gaggttctg  gcctctgaa  cccctttcc  cacacctcc  12360
cctgctgct  ctgccccag  gtcttgacg  gagcattgg  ccctgagcc  agagaagct  12420
gaagcctgc  gaaaacagg  gcaaatggc  ttttataaa  tattttttt  aaataaagc  12480
ctgtgtgcc  gggtcttcc  tgagcaaca  ggagtgggg  gaggtggag  gatccctcc  12540
gcagagttc  gcctacagg  cacggactg  gggcactgg  ccaggccat  ggctccgcc  12600
cctccactg  cccaggagc  agtgtgtgc  tatctgggt  cgcctgtcc  accagcccc  12660
tcttgtgtc  gcgacagtg  gaatgagta  taatgggct  agtccgcat  gcactatac  12720
cggtgggac  cctgtaccc  ctgcacatg  gtgtgtgtg  atgtgtgcc  tgcagctgt  12780
cccaaggga  ctggcagcc  ccctccccc  tctgctcag  attaaccaa  ctgaccgtt  12840
acacagcat  aaaatctga  agccagcct  aggccgcgg  ccgctccca  gctctgccg  12900
ctcaggctg  gggcttgtg  aggccatgc  cgccccgcc  tggccagtc  cccgggcag  12960
agctggttg  cgcccgcct  ggctgcagc  gtccctgcc  gcctggtct  ccactgagg  13020
gccgtcaca  ccctgtact  agagctcct  agagtgagc  gcttctcaa  gctctgagc  13080
tggaacctc  ttccc  13095



<210> 4078
<211> 802
<212> PRT
<213> Homo sapiens
<308> CAA74200
<400> 4078

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
  1               5                  10                  15
Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
             20                  25                  30
Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
         35                  40                  45
Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
     50                  55                  60
His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
 65                  70                  75                  80
Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                 85                  90                  95
Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
             100                105                110
Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
         115                120                125
Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
     130                135                140
Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
 145                150                155                160
Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                 165                170                175
Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
             180                185                190
Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
         195                200                205
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
     210                215                220
Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
 225                230                235                240
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                 245                250                255
Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
             260                265                270
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
         275                280                285
Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
     290                295                300
Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
 305                310                315                320
Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                 325                330                335
Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
             340                345                350
Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
         355                360                365
Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
     370                375                380
Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
 385                390                395                400
Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                 405                410                415
Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
             420                425                430
Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
         435                440                445
Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
     450                455                460
Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
 465                470                475                480
Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                 485                490                495
Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
             500                505                510
Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
         515                520                525
Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
     530                535                540
Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
 545                550                555                560
Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                 565                570                575
Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
             580                585                590
Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
         595                600                605
Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
     610                615                620
Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
 625                630                635                640
Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                 645                650                655
Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
             660                665                670
Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
         675                680                685
Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
     690                695                700
Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
 705                710                715                720
Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                 725                730                735
Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
             740                745                750
Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
         755                760                765
Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
     770                775                780
Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
 785                790                795                800
Gln Thr 
                 805



<210> 4079
<211> 2793
<212> DNA
<213> Rattus norvegicus
<308> M91652
<400> 4079

acagccgag  atgggagta  ggcggagtg  ttgagcagc  cacccattt  ctctccgct  60
ttcgtctcg  tctcgtggc  tgtccaccc  tccatcatc  gccggccac  gctctgaac  120
ccttccacc  tggccacct  agcaagttc  cacttgaac  aaggcatca  gcagatgta  180
atgaacctg  cccagggcg  gaagatcca  ctcatgtat  tctgggttg  tggtaccgg  240
gaagggcta  gctgcaaga  ccgtactct  gactgtgac  ccaagtgtg  agaagagtt  300
cccgagtgg  actttgatg  ttctagtac  tttcagtct  aaggctcca  cagcgacat  360
tacctccat  ctgtggcca  gtttcgaga  cccttccgc  gagacccca  caagctggt  420
ttctgcgaa  tattcaagt  taaccggaa  cccgcagag  ccaacctga  gcacagctg  480
aagcgtata  tggacatgg  gagcagcca  cgcccctgg  ttggaatgg  acaggagta  540
actctcatg  gaacagacg  ccacccttt  ggctggcct  ctaatggct  ccctggacc  600
caaggaccc  attactgcg  tgtgggagc  gacaaggct  atggccgag  tatcgtgga  660
gctcactac  gggcctgct  gtatgctgg  atcaagatc  cagggacaa  tgccgaggt  720
atgcctgcc  agtgggaat  ccagatagg  ccctgcgaa  ggatccgca  gggagatca  780
ctctgggta  cccgtttta  cttgcatcg  gtatgcgaa  actttgggg  gatagcaac  840
tttgacccc  agcccattc  agggaactg  aatggggca  gctgccaca  caactttag  900
accaaggcc  tgcgggagg  gaatggtct  aggtgcatt  aggaggcca  tgataaact  960
agcaagagg  accagtacc  catccgtgc  tacgacccc  aggggggcc  ggacaacgc  1020
cgccgtctg  ctggattcc  cgaaacctc  aacatcaac  acttttccg  tggcgttgc  1080
aaccgcagc  ccagtatcc  cattccccg  attgtcggc  aggagaaga  gggttactt  1140
gaagaccgt  ggccttctg  caattgcga  ccctatgcg  tgacggaag  catcgtccg  1200
acgtgtctc  tcaacgaaa  tggcgacga  cccttccaa  acaagaact  agcggactc  1260
acttccagt  atcttgagc  cttcctagt  caccccact  ccaactgtt  cctctccca  1320
tggtcccca  tgtaactca  aaggatgga  taccaaggt  tttttattc  ttgcgccca  1380
ttaattttt  cctttattg  tcagaatag  ggggtcagg  tcttaatct  tacacaccc  1440
accccttct  tcctagcta  ctttccagt  ggggaacgg  agggggtgg  gaagggtaa  1500
ccaccgctt  atctcagcg  gaatgcatg  cctgtaggc  tagctgtca  aaatcgggt  1560
tacttgtgg  gagggagga  tggtttttt  tttccttca  gataattga  agggcaggc  1620
caacagctt  gattaacat  ttctctgtc  gtagagagc  gttatttct  ccggtgaaa  1680
cagctttct  ttgaagtct  gtgaggagt  ggaggttgg  ctcttggct  ccttagctt  1740
gggaagggg  gttcaccct  ccttcatga  acacagttc  cctgacaaa  ggccctact  1800
taaaggaag  aaaaagttt  ttggtcctc  atttataac  caaagcaga  tagtatttt  1860
atatttaaa  gttaaaaac  aaaaagtta  atatatggg  gtgtggata  atatgtctt  1920
tctaattga  aaaaccatc  tattccctg  gtgccaagt  tgagtgagg  gctcggtgt  1980
gaagtgagg  actcttgag  taggggtgg  gatgcagta  tgggaaagt  ggttatctt  2040
ggggttcag  ttcattact  cttagggtt  ccctgccca  tctgcagga  cagatgttg  2100
acaggtagc  agtgggatg  cactgcttg  cgccactgt  cctgggctt  gtttaaggg  2160
acgtgtata  ctaatccac  cacgagtta  aagtatgag  tggctggtc  acttgaaca  2220
tgttacagg  gggtgggtg  tagtggggg  ttatttttt  gtgggacta  catgtcact  2280
aagcgggcc  tttgatata  taaattttt  aaagcaaaa  aagtttaga  tttaatcaa  2340
ttcgtaggg  ttctaactt  acagaattg  ctgtttgtt  caatgactc  ttccacttg  2400
ctcttaggg  aactgagga  aggcctgga  ttaatacac  tgtcattct  tgtcctagt  2460
tcctcttcc  ccggcagac  gtccccttc  ttctgaaaa  gccgataga  tcttgtttt  2520
tttttcttt  ataataaac  caccccacc  ccatcccag  ttgttgcct  gcagttttc  2580
ggatgtttg  gtcggcagc  ggcagctgt  gtttttttc  cttgccacg  tgactctaa  2640
taccatgta  agtatgttc  gttagataa  tcactgtaa  cagactgta  ctgagagca  2700
agcttgtaa  tcaacctaa  gtttataag  tttcctctg  cttgtttct  tgtggttcc  2760
aaaaaaaaa  aaaaaaaaa  aacctcaaa  act  2793



<210> 4080
<211> 373
<212> PRT
<213> Rattus norvegicus
<308> P09606
<400> 4080

Met Ala Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Met 
  1               5                  10                  15
Tyr Met Asn Leu Pro Gln Gly Glu Lys Ile Gln Leu Met Tyr Ile Trp 
             20                  25                  30
Val Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
         35                  40                  45
Cys Asp Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
     50                  55                  60
Ser Ser Thr Phe Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu His 
 65                  70                  75                  80
Pro Val Ala Met Phe Arg Asp Pro Phe Arg Arg Asp Pro Asn Lys Leu 
                 85                  90                  95
Val Phe Cys Glu Val Phe Lys Tyr Asn Arg Lys Pro Ala Glu Thr Asn 
             100                105                110
Leu Arg His Ser Cys Lys Arg Ile Met Asp Met Val Ser Ser Gln His 
         115                120                125
Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
     130                135                140
His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
 145                150                155                160
Tyr Tyr Cys Gly Val Gly Ala Asp Lys Ala Tyr Gly Arg Asp Ile Val 
                 165                170                175
Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Ile Lys Ile Thr Gly 
             180                185                190
Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
         195                200                205
Cys Glu Gly Ile Arg Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
     210                215                220
Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
 225                230                235                240
Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                 245                250                255
Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Arg Cys Ile Glu Glu 
             260                265                270
Ala Ile Asp Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
         275                280                285
Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
     290                295                300
Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 
 305                310                315                320
Ala Ser Ile Arg Ile Pro Arg Ile Val Gly Gln Glu Lys Lys Gly Tyr 
                 325                330                335
Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Tyr Ala Val Thr 
             340                345                350
Glu Ala Ile Val Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
         355                360                365
Phe Gln Tyr Lys Asn 
     370



<210> 4081
<211> 1366
<212> DNA
<213> Homo sapiens
<308> Y00387
<400> 4081

cgcgagagc  ggttaggag  ggagaggag  ccgcagtac  gctcacacg  tccgctctt  60
tcccactct  ggcctacct  tacccgccc  cctgctcgg  gaccagaac  ccttccacc  120
tgaccacct  agcaagttc  cacttaaat  aaggcatca  gcaggtgta  atgtccctg  180
ctcagggtg  gaaagtcca  gccatgtat  tctggatcg  tggtactgg  gaaggactg  240
gctgcaaga  ccggaccct  gacagtgag  ccaagtgtg  ggaagagtt  cctgagtgg  300
atttcgatg  ctccagtac  ttacagtct  agggttcca  cagtgacat  tatctcgtg  360
ctgctgcca  gtttcggga  cccttccgt  aggacccta  caagctggt  ttatgtgaa  420
ttttcaagt  caatcgaag  cctgcagag  ccaatttga  gcacacctg  aaacggata  480
tggacatgg  gagcaacca  cacccctgg  ttggcatgg  gcaggagta  accctcatg  540
ggacagatg  gcacccctt  ggttggcct  ccaacggct  cccagggcc  cagggtcca  600
attactgtg  tgtgggagc  gacagagcc  atggcaggg  catcgtgga  gcccattac  660
gggcctgct  gtatgctgg  gtcaagatt  cggggacta  tgccgaggt  atgcctgcc  720
agtgggaat  tcagattgg  ccttgtgaa  gaatcagca  gggagatca  ctctgggtg  780
cccgtttca  cttgcatcg  gtgtgtgaa  actttggag  gatagcaac  tttgatcct  840
agcccattc  tgggaactg  aatggtgca  gctgccata  caacttcag  accaaggcc  900
tgcgggagg  gaatggtct  aagtacatc  aggaggcca  tgagaaact  agcaagcgg  960
accagtacc  catccgtgc  tatgatccc  agggaggcc  ggacaatgc  cgacgtcta  1020
ctggattcc  tgaaacctc  aacatcaac  acttttctg  tggtgtagc  aatcgtagc  1080
ccagcatac  cattccccg  actgttggc  aggagaaga  gggttactt  gaagatcgt  1140
gcccctctg  caactgcga  cccttttcg  tgacagaag  cctcatccg  acgtgtctt  1200
tcaatgaaa  cggcgatga  cccttccag  acaaaaatt  agtggacta  acctccagc  1260
gttgagccc  tcctagttc  tcatcccac  ccaactctt  cccctctcc  agttgtccc  1320
attgtaact  aaagggtgg  atatcaagg  cgttttttt  cattcc  1366



<210> 4082
<211> 373
<212> PRT
<213> Homo sapiens
<308> P15104
<400> 4082

Met Thr Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Val 
  1               5                  10                  15
Tyr Met Ser Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
             20                  25                  30
Ile Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
         35                  40                  45
Ser Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
     50                  55                  60
Ser Ser Thr Leu Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu Val 
 65                  70                  75                  80
Pro Ala Ala Met Phe Arg Asp Pro Phe Arg Lys Asp Pro Asn Lys Leu 
                 85                  90                  95
Val Leu Cys Glu Val Phe Lys Tyr Asn Arg Arg Pro Ala Glu Thr Asn 
             100                105                110
Leu Arg His Thr Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 
         115                120                125
Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
     130                135                140
His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
 145                150                155                160
Tyr Tyr Cys Gly Val Gly Ala Asp Arg Ala Tyr Gly Arg Asp Ile Val 
                 165                170                175
Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Ala Gly 
             180                185                190
Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
         195                200                205
Cys Glu Gly Ile Ser Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
     210                215                220
Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
 225                230                235                240
Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                 245                250                255
Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys Tyr Ile Glu Glu 
             260                265                270
Ala Ile Glu Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
         275                280                285
Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
     290                295                300
Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 
 305                310                315                320
Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 
                 325                330                335
Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Phe Ser Val Thr 
             340                345                350
Glu Ala Leu Ile Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
         355                360                365
Phe Gln Tyr Lys Asn 
     370



<210> 4083
<211> 2793
<212> DNA
<213> Rattus norvegicus
<308> M91652
<400> 4083

acagccgag  atgggagta  ggcggagtg  ttgagcagc  cacccattt  ctctccgct  60
ttcgtctcg  tctcgtggc  tgtccaccc  tccatcatc  gccggccac  gctctgaac  120
ccttccacc  tggccacct  agcaagttc  cacttgaac  aaggcatca  gcagatgta  180
atgaacctg  cccagggcg  gaagatcca  ctcatgtat  tctgggttg  tggtaccgg  240
gaagggcta  gctgcaaga  ccgtactct  gactgtgac  ccaagtgtg  agaagagtt  300
cccgagtgg  actttgatg  ttctagtac  tttcagtct  aaggctcca  cagcgacat  360
tacctccat  ctgtggcca  gtttcgaga  cccttccgc  gagacccca  caagctggt  420
ttctgcgaa  tattcaagt  taaccggaa  cccgcagag  ccaacctga  gcacagctg  480
aagcgtata  tggacatgg  gagcagcca  cgcccctgg  ttggaatgg  acaggagta  540
actctcatg  gaacagacg  ccacccttt  ggctggcct  ctaatggct  ccctggacc  600
caaggaccc  attactgcg  tgtgggagc  gacaaggct  atggccgag  tatcgtgga  660
gctcactac  gggcctgct  gtatgctgg  atcaagatc  cagggacaa  tgccgaggt  720
atgcctgcc  agtgggaat  ccagatagg  ccctgcgaa  ggatccgca  gggagatca  780
ctctgggta  cccgtttta  cttgcatcg  gtatgcgaa  actttgggg  gatagcaac  840
tttgacccc  agcccattc  agggaactg  aatggggca  gctgccaca  caactttag  900
accaaggcc  tgcgggagg  gaatggtct  aggtgcatt  aggaggcca  tgataaact  960
agcaagagg  accagtacc  catccgtgc  tacgacccc  aggggggcc  ggacaacgc  1020
cgccgtctg  ctggattcc  cgaaacctc  aacatcaac  acttttccg  tggcgttgc  1080
aaccgcagc  ccagtatcc  cattccccg  attgtcggc  aggagaaga  gggttactt  1140
gaagaccgt  ggccttctg  caattgcga  ccctatgcg  tgacggaag  catcgtccg  1200
acgtgtctc  tcaacgaaa  tggcgacga  cccttccaa  acaagaact  agcggactc  1260
acttccagt  atcttgagc  cttcctagt  caccccact  ccaactgtt  cctctccca  1320
tggtcccca  tgtaactca  aaggatgga  taccaaggt  tttttattc  ttgcgccca  1380
ttaattttt  cctttattg  tcagaatag  ggggtcagg  tcttaatct  tacacaccc  1440
accccttct  tcctagcta  ctttccagt  ggggaacgg  agggggtgg  gaagggtaa  1500
ccaccgctt  atctcagcg  gaatgcatg  cctgtaggc  tagctgtca  aaatcgggt  1560
tacttgtgg  gagggagga  tggtttttt  tttccttca  gataattga  agggcaggc  1620
caacagctt  gattaacat  ttctctgtc  gtagagagc  gttatttct  ccggtgaaa  1680
cagctttct  ttgaagtct  gtgaggagt  ggaggttgg  ctcttggct  ccttagctt  1740
gggaagggg  gttcaccct  ccttcatga  acacagttc  cctgacaaa  ggccctact  1800
taaaggaag  aaaaagttt  ttggtcctc  atttataac  caaagcaga  tagtatttt  1860
atatttaaa  gttaaaaac  aaaaagtta  atatatggg  gtgtggata  atatgtctt  1920
tctaattga  aaaaccatc  tattccctg  gtgccaagt  tgagtgagg  gctcggtgt  1980
gaagtgagg  actcttgag  taggggtgg  gatgcagta  tgggaaagt  ggttatctt  2040
ggggttcag  ttcattact  cttagggtt  ccctgccca  tctgcagga  cagatgttg  2100
acaggtagc  agtgggatg  cactgcttg  cgccactgt  cctgggctt  gtttaaggg  2160
acgtgtata  ctaatccac  cacgagtta  aagtatgag  tggctggtc  acttgaaca  2220
tgttacagg  gggtgggtg  tagtggggg  ttatttttt  gtgggacta  catgtcact  2280
aagcgggcc  tttgatata  taaattttt  aaagcaaaa  aagtttaga  tttaatcaa  2340
ttcgtaggg  ttctaactt  acagaattg  ctgtttgtt  caatgactc  ttccacttg  2400
ctcttaggg  aactgagga  aggcctgga  ttaatacac  tgtcattct  tgtcctagt  2460
tcctcttcc  ccggcagac  gtccccttc  ttctgaaaa  gccgataga  tcttgtttt  2520
tttttcttt  ataataaac  caccccacc  ccatcccag  ttgttgcct  gcagttttc  2580
ggatgtttg  gtcggcagc  ggcagctgt  gtttttttc  cttgccacg  tgactctaa  2640
taccatgta  agtatgttc  gttagataa  tcactgtaa  cagactgta  ctgagagca  2700
agcttgtaa  tcaacctaa  gtttataag  tttcctctg  cttgtttct  tgtggttcc  2760
aaaaaaaaa  aaaaaaaaa  aacctcaaa  act  2793



<210> 4084
<211> 373
<212> PRT
<213> Rattus norvegicus
<308> P09606
<400> 4084

Met Ala Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Met 
  1               5                  10                  15
Tyr Met Asn Leu Pro Gln Gly Glu Lys Ile Gln Leu Met Tyr Ile Trp 
             20                  25                  30
Val Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
         35                  40                  45
Cys Asp Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
     50                  55                  60
Ser Ser Thr Phe Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu His 
 65                  70                  75                  80
Pro Val Ala Met Phe Arg Asp Pro Phe Arg Arg Asp Pro Asn Lys Leu 
                 85                  90                  95
Val Phe Cys Glu Val Phe Lys Tyr Asn Arg Lys Pro Ala Glu Thr Asn 
             100                105                110
Leu Arg His Ser Cys Lys Arg Ile Met Asp Met Val Ser Ser Gln His 
         115                120                125
Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
     130                135                140
His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
 145                150                155                160
Tyr Tyr Cys Gly Val Gly Ala Asp Lys Ala Tyr Gly Arg Asp Ile Val 
                 165                170                175
Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Ile Lys Ile Thr Gly 
             180                185                190
Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
         195                200                205
Cys Glu Gly Ile Arg Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
     210                215                220
Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
 225                230                235                240
Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                 245                250                255
Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Arg Cys Ile Glu Glu 
             260                265                270
Ala Ile Asp Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
         275                280                285
Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
     290                295                300
Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 
 305                310                315                320
Ala Ser Ile Arg Ile Pro Arg Ile Val Gly Gln Glu Lys Lys Gly Tyr 
                 325                330                335
Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Tyr Ala Val Thr 
             340                345                350
Glu Ala Ile Val Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
         355                360                365
Phe Gln Tyr Lys Asn 
     370



<210> 4085
<211> 1366
<212> DNA
<213> Homo sapiens
<308> Y00387
<400> 4085

cgcgagagc  ggttaggag  ggagaggag  ccgcagtac  gctcacacg  tccgctctt  60
tcccactct  ggcctacct  tacccgccc  cctgctcgg  gaccagaac  ccttccacc  120
tgaccacct  agcaagttc  cacttaaat  aaggcatca  gcaggtgta  atgtccctg  180
ctcagggtg  gaaagtcca  gccatgtat  tctggatcg  tggtactgg  gaaggactg  240
gctgcaaga  ccggaccct  gacagtgag  ccaagtgtg  ggaagagtt  cctgagtgg  300
atttcgatg  ctccagtac  ttacagtct  agggttcca  cagtgacat  tatctcgtg  360
ctgctgcca  gtttcggga  cccttccgt  aggacccta  caagctggt  ttatgtgaa  420
ttttcaagt  caatcgaag  cctgcagag  ccaatttga  gcacacctg  aaacggata  480
tggacatgg  gagcaacca  cacccctgg  ttggcatgg  gcaggagta  accctcatg  540
ggacagatg  gcacccctt  ggttggcct  ccaacggct  cccagggcc  cagggtcca  600
attactgtg  tgtgggagc  gacagagcc  atggcaggg  catcgtgga  gcccattac  660
gggcctgct  gtatgctgg  gtcaagatt  cggggacta  tgccgaggt  atgcctgcc  720
agtgggaat  tcagattgg  ccttgtgaa  gaatcagca  gggagatca  ctctgggtg  780
cccgtttca  cttgcatcg  gtgtgtgaa  actttggag  gatagcaac  tttgatcct  840
agcccattc  tgggaactg  aatggtgca  gctgccata  caacttcag  accaaggcc  900
tgcgggagg  gaatggtct  aagtacatc  aggaggcca  tgagaaact  agcaagcgg  960
accagtacc  catccgtgc  tatgatccc  agggaggcc  ggacaatgc  cgacgtcta  1020
ctggattcc  tgaaacctc  aacatcaac  acttttctg  tggtgtagc  aatcgtagc  1080
ccagcatac  cattccccg  actgttggc  aggagaaga  gggttactt  gaagatcgt  1140
gcccctctg  caactgcga  cccttttcg  tgacagaag  cctcatccg  acgtgtctt  1200
tcaatgaaa  cggcgatga  cccttccag  acaaaaatt  agtggacta  acctccagc  1260
gttgagccc  tcctagttc  tcatcccac  ccaactctt  cccctctcc  agttgtccc  1320
attgtaact  aaagggtgg  atatcaagg  cgttttttt  cattcc  1366



<210> 4086
<211> 373
<212> PRT
<213> Homo sapiens
<308> P15104
<400> 4086

Met Thr Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Val 
  1               5                  10                  15
Tyr Met Ser Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
             20                  25                  30
Ile Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
         35                  40                  45
Ser Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
     50                  55                  60
Ser Ser Thr Leu Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu Val 
 65                  70                  75                  80
Pro Ala Ala Met Phe Arg Asp Pro Phe Arg Lys Asp Pro Asn Lys Leu 
                 85                  90                  95
Val Leu Cys Glu Val Phe Lys Tyr Asn Arg Arg Pro Ala Glu Thr Asn 
             100                105                110
Leu Arg His Thr Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 
         115                120                125
Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
     130                135                140
His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
 145                150                155                160
Tyr Tyr Cys Gly Val Gly Ala Asp Arg Ala Tyr Gly Arg Asp Ile Val 
                 165                170                175
Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Ala Gly 
             180                185                190
Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
         195                200                205
Cys Glu Gly Ile Ser Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
     210                215                220
Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
 225                230                235                240
Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                 245                250                255
Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys Tyr Ile Glu Glu 
             260                265                270
Ala Ile Glu Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
         275                280                285
Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
     290                295                300
Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 
 305                310                315                320
Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 
                 325                330                335
Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Phe Ser Val Thr 
             340                345                350
Glu Ala Leu Ile Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
         355                360                365
Phe Gln Tyr Lys Asn 
     370



<210> 4087
<211> 1576
<212> DNA
<213> Rattus norvegicus
<308> M91802
<400> 4087

ttaattctc  gagacaagg  tgaaattgg  ccgaattgg  tgtaatcag  gaaccagaa  60
aaaaacacc  cagcagcga  cttctatga  agatttttt  ttccttcgc  ctcgccttt  120
tcctgggcc  tgccccccc  aagcccctc  aaaagaggg  acttttcct  cgagagggc  180
ccaaggaga  ggccatgaa  tacgaattt  agcgagaga  tggttttat  aatagccag  240
cgtcgctcg  tgagtgcct  acatctttt  cccctgtcg  tgatacatt  caaagttca  300
caatcaaga  ctcgacgct  tcacactcg  cactgattc  tcctccttt  gagcagacc  360
ttcccagcc  gaacccggg  agtcaccct  gccaaagcg  tggcgctgg  ggccgcccc  420
agtcgagcc  cgcgggcag  cgcggcagc  cggtgcccg  ccgcgccct  cagccgcct  480
agtacccct  gatgaagga  aagaaggcg  ccaagaaaa  cgcgctgcc  cccgccgcc  540
cctccacgg  ccctgcctg  ctcggccac  aagaatccc  ggaaatagc  gatggcagc  600
gtgggggat  caggcgtct  agaactgct  acaccaaca  tcagctttt  gaactggaa  660
aggaatttc  tttcaacaa  tacctctgc  gaccccgga  ggtggaaat  gccgcgctg  720
tggatttga  cgagagaca  gtgaaagtg  ggtttcaga  ccggaggat  aagcataag  780
ggcaaaccc  gtgcaagga  aaccaaaac  gcgaaggga  atttaaaaa  ctggaggat  840
cggacaaag  ggaggaaga  gaggaagag  agtcactct  tgagcaagc  ctcagtgtc  900
ccggggccc  tctggagag  gaaggttac  cttttcagc  aaacgcgct  tctcaacag  960
aggctccca  tggacacaa  ggcgactcc  aaactttcc  agtttcgcc  ttaaccagc  1020
atgagaaaa  tttgaaaca  tttcagcac  agtcaccca  tgttcctaa  tgcttgtca  1080
caatgggcc  gaactgtgg  gctggccta  acaatgaca  tcccgaggc  ctcgaggtc  1140
cctctttgc  ggactttaa  gttttctcc  cagattcct  cctgcagct  tcagacgca  1200
tgtcgccca  tttgccagg  tccctgggc  gtcctgtag  tatttcagc  gacagcttt  1260
actttttta  agacacact  accacaatc  acctacagc  tctgaatta  taagaacat  1320
aaagcaaaa  aaagcttca  aaaacaaaa  gcctttggc  aggtgcttt  ccttctttt  1380
ttccgggag  tgattttcg  tctattctc  tctcgatct  cccctgttc  cttaaatgt  1440
caggacttt  tgttttaca  ccagtttga  agccatctc  tccaaatga  gttggcgtt  1500
taagtgttt  acaccgaac  caacaagct  ctatgtgat  ttcctgaaa  caaaacacg  1560
ggcctgcaa  aaagtg  1576



<210> 4088
<211> 372
<212> PRT
<213> Rattus norvegicus
<308> P31246
<400> 4088

Met Asn Tyr Glu Phe Glu Arg Glu Ile Gly Phe Ile Asn Ser Gln Pro 
  1               5                  10                  15
Ser Leu Ala Glu Cys Leu Thr Ser Phe Pro Pro Val Ala Asp Thr Phe 
             20                  25                  30
Gln Ser Ser Ser Ile Lys Thr Ser Thr Leu Ser His Ser Thr Leu Ile 
         35                  40                  45
Pro Pro Pro Phe Glu Gln Thr Ile Pro Ser Leu Asn Pro Gly Ser His 
     50                  55                  60
Pro Arg Gln Ser Ala Gly Ala Gly Gly Arg Pro Lys Ser Ser Pro Ala 
 65                  70                  75                  80
Gly Ser Arg Gly Ser Pro Val Pro Ala Arg Ala Leu Gln Pro Pro Glu 
                 85                  90                  95
Tyr Pro Trp Met Lys Glu Lys Lys Ala Ala Lys Lys Thr Ala Leu Pro 
             100                105                110
Pro Ala Ala Ala Ser Thr Gly Pro Ala Cys Leu Gly His Lys Glu Ser 
         115                120                125
Leu Glu Ile Ala Asp Gly Ser Gly Gly Gly Ser Arg Arg Leu Arg Thr 
     130                135                140
Ala Tyr Thr Asn Thr Gln Leu Leu Glu Leu Glu Lys Glu Phe His Phe 
 145                150                155                160
Asn Lys Tyr Leu Cys Arg Pro Arg Arg Val Glu Ile Ala Ala Leu Leu 
                 165                170                175
Asp Leu Thr Glu Arg Gln Val Lys Val Trp Phe Gln Asn Arg Arg Met 
             180                185                190
Lys His Lys Arg Gln Thr Gln Cys Lys Glu Asn Gln Asn Ser Glu Gly 
         195                200                205
Lys Phe Lys Asn Leu Glu Asp Ser Asp Lys Val Glu Glu Asp Glu Glu 
     210                215                220
Glu Lys Ser Leu Phe Glu Gln Ala Leu Ser Val Ser Gly Ala Leu Leu 
 225                230                235                240
Glu Arg Glu Gly Tyr Thr Phe Gln Gln Asn Ala Leu Ser Gln Gln Gln 
                 245                250                255
Ala Pro Asn Gly His Asn Gly Asp Ser Gln Thr Phe Pro Val Ser Pro 
             260                265                270
Leu Thr Ser Asn Glu Lys Asn Leu Lys His Phe Gln His Gln Ser Pro 
         275                280                285
Thr Val Pro Asn Cys Leu Ser Thr Met Gly Gln Asn Cys Gly Ala Gly 
     290                295                300
Leu Asn Asn Asp Ser Pro Glu Ala Leu Glu Val Pro Ser Leu Gln Asp 
 305                310                315                320
Phe Asn Val Phe Ser Thr Asp Ser Cys Leu Gln Leu Ser Asp Ala Leu 
                 325                330                335
Ser Pro Ser Leu Pro Gly Ser Leu Gly Ser Pro Val Asp Ile Ser Ala 
             340                345                350
Asp Ser Phe Asp Phe Phe Thr Asp Thr Leu Thr Thr Ile Asp Leu Gln 
         355                360                365
His Leu Asn Tyr 
     370



<210> 4089
<211> 1131
<212> DNA
<213> Homo sapiens
<308> NM_006735
<400> 4089

atgaattac  aatttgagc  agagattgg  tttatcaat  gccagccgt  gctcgctga  60
tgcctgaca  cttttcccc  tgtcgctga  acatttcaa  gttcatcaa  caagacctc  120
acgctttca  actcgacac  gattcctcc  ccttttgag  agaccattc  cagcctgaa  180
cccggcagt  accctcgcc  cggcgctgg  ggccgcccc  agccgagcc  cgcgggcag  240
cgcggcagc  cggtgcccg  cggcgccct  cagccgccc  agtacccct  gatgaagga  300
aagaaggcg  ccaagaaaa  cgcacttct  ccggccgcc  ccgccgccg  caccgccgc  360
gccaccggc  ctgcttgcc  cagccacaa  gaatccctg  aaatcgccg  tggcagcgg  420
gggggatcg  ggcgcctga  aactgctta  accaacaca  agcttctag  gctggaaaa  480
gaatttcat  tcaacaagt  cctttgcag  ccccgaagg  tggagattg  agcgctgct  540
gatttgact  agagacaag  gaaagtgtg  tttcagaac  ggaggatga  gcacaagag  600
cagacccag  gcaaggaaa  ccaaaacag  gaagggaaa  gtaaaagcc  tgaggactc  660
gagaaagta  aggaggacg  ggaagagaa  acgctcttt  agcaagccc  tagcgtctc  720
ggggccctt  tggagaggg  aggctacac  tttcagcaa  atgccctct  tcagcagca  780
gctcccaat  gacacaatg  cgactccca  agtttccca  tctcgcctt  aaccagcaa  840
gagaaaaat  tgaaacatt  tcagcacca  tcacccact  ttcccaact  cttgtcaac  900
atgggccag  actgtggag  tggcctaaa  aatgacagt  ctgaggccc  tgaggtccc  960
tctttgcag  actttagcg  tttctccac  gattcctgc  tgcagcttt  agatgcagt  1020
tcacccagt  tgccaggtt  cctcgacag  cccgtagat  tttcagctg  cagcttaga  1080
ttttttaca  acacactca  cacaatcga  ttgcagcat  tgaattact  a  1131



<210> 4090
<211> 376
<212> PRT
<213> Homo sapiens
<308> NP_006726
<400> 4090

Met Asn Tyr Glu Phe Glu Arg Glu Ile Gly Phe Ile Asn Ser Gln Pro 
  1               5                  10                  15
Ser Leu Ala Glu Cys Leu Thr Ser Phe Pro Pro Val Ala Asp Thr Phe 
             20                  25                  30
Gln Ser Ser Ser Ile Lys Thr Ser Thr Leu Ser His Ser Thr Leu Ile 
         35                  40                  45
Pro Pro Pro Phe Glu Gln Thr Ile Pro Ser Leu Asn Pro Gly Ser His 
     50                  55                  60
Pro Arg His Gly Ala Gly Gly Arg Pro Lys Pro Ser Pro Ala Gly Ser 
 65                  70                  75                  80
Arg Gly Ser Pro Val Pro Ala Gly Ala Leu Gln Pro Pro Glu Tyr Pro 
                 85                  90                  95
Trp Met Lys Glu Lys Lys Ala Ala Lys Lys Thr Ala Leu Leu Pro Ala 
             100                105                110
Ala Ala Ala Ala Ala Thr Ala Ala Ala Thr Gly Pro Ala Cys Leu Ser 
         115                120                125
His Lys Glu Ser Leu Glu Ile Ala Asp Gly Ser Gly Gly Gly Ser Arg 
     130                135                140
Arg Leu Arg Thr Ala Tyr Thr Asn Thr Gln Leu Leu Glu Leu Glu Lys 
 145                150                155                160
Glu Phe His Phe Asn Lys Tyr Leu Cys Arg Pro Arg Arg Val Glu Ile 
                 165                170                175
Ala Ala Leu Leu Asp Leu Thr Glu Arg Gln Val Lys Val Trp Phe Gln 
             180                185                190
Asn Arg Arg Met Lys His Lys Arg Gln Thr Gln Cys Lys Glu Asn Gln 
         195                200                205
Asn Ser Glu Gly Lys Cys Lys Ser Leu Glu Asp Ser Glu Lys Val Glu 
     210                215                220
Glu Asp Glu Glu Glu Lys Thr Leu Phe Glu Gln Ala Leu Ser Val Ser 
 225                230                235                240
Gly Ala Leu Leu Glu Arg Glu Gly Tyr Thr Phe Gln Gln Asn Ala Leu 
                 245                250                255
Ser Gln Gln Gln Ala Pro Asn Gly His Asn Gly Asp Ser Gln Ser Phe 
             260                265                270
Pro Val Ser Pro Leu Thr Ser Asn Glu Lys Asn Leu Lys His Phe Gln 
         275                280                285
His Gln Ser Pro Thr Val Pro Asn Cys Leu Ser Thr Met Gly Gln Asn 
     290                295                300
Cys Gly Ala Gly Leu Asn Asn Asp Ser Pro Glu Ala Leu Glu Val Pro 
 305                310                315                320
Ser Leu Gln Asp Phe Ser Val Phe Ser Thr Asp Ser Cys Leu Gln Leu 
                 325                330                335
Ser Asp Ala Val Ser Pro Ser Leu Pro Gly Ser Leu Asp Ser Pro Val 
             340                345                350
Asp Ile Ser Ala Asp Ser Leu Asp Phe Phe Thr Asp Thr Leu Thr Thr 
         355                360                365
Ile Asp Leu Gln His Leu Asn Tyr 
     370                375



<210> 4091
<211> 832
<212> DNA
<213> Rattus norvegicus
<308> M92059
<400> 4091

gcggccgcc  tgtacctcg  ggctctggt  gtcctggag  cggctgtat  tgttgcgca  60
ccccgaggt  ggattctgg  tggccagga  gccatggcc  atgctcggc  ctacatggc  120
tcagtgcaa  tgaatggca  gcacgtgtg  ggtggcacc  tggtggatg  gcagtgggt  180
ctgagcgcc  cgcactgca  ggatggagt  accaaggat  aggttgtgc  ggtgctcct  240
ggtgcccac  ccctgtcca  tcctgaacc  tacaagcat  tgtatgatg  gcaaagtgt  300
gtgcttcac  cgggcagcc  gcctgacag  gttgaggac  acctcatgc  ctttaagct  360
tcccacaat  cctcactgg  tccccatgt  agacccctg  ccttgcaac  cgaggaccg  420
gaggtgaaa  ccggcacgc  ctgcgatgt  gccggttgg  gcgtggtca  tcatgcggg  480
cgcaggccc  atgtcctgc  gcaactgac  gtgtcaatc  tggaccgga  cacctgcaa  540
ctgcgcacg  accatgatg  ggcaatcac  aagaacatg  tgtgtgcag  gagcaaccg  600
agggacact  gcaggggcg  ctccggcgg  cctctggtg  gcggggatg  ggtcgaagc  660
gtggttacg  ggggatctc  agtctgtgg  aaccggaga  agccaggtg  ctttacccg  720
gtggcaacc  acgtgccgt  gattgaaaa  gttctgagt  gtaacgtga  tgttaacgt  780
acggcctga  gggacaccg  agaccgtga  tcacaataa  tgcagcggc  gc  832



<210> 4092
<211> 263
<212> PRT
<213> Rattus norvegicus
<308> AAB31922
<400> 4092

Met His Ser Ser Val Tyr Leu Val Ala Leu Val Val Leu Glu Ala Ala 
  1               5                  10                  15
Val Cys Val Ala Gln Pro Arg Gly Arg Ile Leu Gly Gly Gln Glu Ala 
             20                  25                  30
Met Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Val Asn Gly Thr 
         35                  40                  45
His Val Cys Gly Gly Thr Leu Val Asp Glu Gln Trp Val Leu Ser Ala 
     50                  55                  60
Ala His Cys Met Asp Gly Val Thr Lys Asp Glu Val Val Gln Val Leu 
 65                  70                  75                  80
Leu Gly Ala His Ser Leu Ser Ser Pro Glu Pro Tyr Lys His Leu Tyr 
                 85                  90                  95
Asp Val Gln Ser Val Val Leu His Pro Gly Ser Arg Pro Asp Ser Val 
             100                105                110
Glu Asp Asp Leu Met Leu Phe Lys Leu Ser His Asn Ala Ser Leu Gly 
         115                120                125
Pro His Val Arg Pro Leu Pro Leu Gln Arg Glu Asp Arg Glu Val Lys 
     130                135                140
Pro Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Val Val Thr His Ala 
 145                150                155                160
Gly Arg Arg Pro Asp Val Leu Gln Gln Leu Thr Val Ser Ile Met Asp 
                 165                170                175
Arg Asn Thr Cys Asn Leu Arg Thr Tyr His Asp Gly Ala Ile Thr Lys 
             180                185                190
Asn Met Met Cys Ala Glu Ser Asn Arg Arg Asp Thr Cys Arg Gly Asp 
         195                200                205
Ser Gly Gly Pro Leu Val Cys Gly Asp Ala Val Glu Ala Val Val Thr 
     210                215                220
Trp Gly Ser Arg Val Cys Gly Asn Arg Arg Lys Pro Gly Val Phe Thr 
 225                230                235                240
Arg Val Ala Thr Tyr Val Pro Trp Ile Glu Asn Val Leu Ser Gly Asn 
                 245                250                255
Val Ser Val Asn Val Thr Ala 
             260



<210> 4093
<211> 762
<212> DNA
<213> Homo sapiens
<308> AJ313463
<400> 4093

atgcacagc  gggagcgcc  ggcagttct  gtcctccta  gagcggccg  ctgcgcggc  60
ccgccccgt  gtcggatcc  gggcggcag  gaggccgag  cgcacgcgc  gccctacat  120
gcgtcggtg  agctgaacg  cgcgcacct  tgcggcggc  tcctggtgg  ggagcagtg  180
gtgctgagc  cggcgcact  cctggagga  gcggccgac  ggaaggtgc  ggttctcct  240
ggcgcgcac  ccctgtcgc  gccggagcc  tccaagcgc  tgtacgacg  gctccgcgc  300
gtgccccac  cggacagcc  gcccgacac  atcgaccac  acctcctgc  gctacagct  360
tcggagaag  ccacactgg  ccctgctgt  cgccccctg  cctggcagc  cgtggaccg  420
gacgtggca  cgggaactc  ctgcgacgt  gccggctgg  gcatagtca  ccacgcggg  480
cgccgcccg  acagcctgc  gcacgtgct  ttgccagtg  tggaccgcg  cacctgcaa  540
cggcgcacg  accacgacg  cgccatcac  gagcgcttg  tgtgcgcgg  gagcaatcg  600
cgggacagc  gcaagggtg  ctccggggg  ccgctggtg  gcgggggcg  gctcgaggg  660
gtggtcacc  cgggctcgc  cgtttgcgg  aaccgcaag  agcccggga  ctacacccg  720
gtggcgagc  atgcggcct  gatcgacag  gtcctggcc  ag  762



<210> 4094
<211> 253
<212> PRT
<213> Homo sapiens
<308> P00746
<400> 4094

Met His Ser Ser Val Tyr Phe Ala Val Leu Val Leu Leu Gly Ala Ala 
  1               5                  10                  15
Ala Cys Ala Ala Arg Pro Arg Gly Arg Ile Leu Gly Gly Arg Glu Ala 
             20                  25                  30
Glu Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Leu Asn Gly Ala 
         35                  40                  45
His Leu Cys Gly Gly Val Leu Val Ala Glu Gln Trp Val Leu Ser Ala 
     50                  55                  60
Ala His Cys Leu Glu Asp Ala Ala Asp Gly Lys Val Gln Val Leu Leu 
 65                  70                  75                  80
Gly Ala His Ser Leu Ser Gln Pro Glu Pro Ser Lys Arg Leu Tyr Asp 
                 85                  90                  95
Val Leu Arg Ala Val Pro His Pro Asp Ser Gln Pro Asp Thr Ile Asp 
             100                105                110
His Asp Leu Leu Leu Leu Gln Leu Ser Glu Lys Ala Thr Leu Gly Pro 
         115                120                125
Ala Val Arg Pro Leu Pro Trp Gln Arg Val Asp Arg Asp Val Ala Pro 
     130                135                140
Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Ile Val Asn His Ala Gly 
 145                150                155                160
Arg Arg Pro Asp Ser Leu Gln His Val Leu Leu Pro Val Leu Asp Arg 
                 165                170                175
Ala Thr Cys Asn Arg Arg Thr His His Asp Gly Ala Ile Thr Glu Arg 
             180                185                190
Leu Met Cys Ala Glu Ser Asn Arg Arg Asp Ser Cys Lys Gly Asp Ser 
         195                200                205
Gly Gly Pro Leu Val Cys Gly Gly Val Leu Glu Gly Val Val Thr Ser 
     210                215                220
Gly Ser Arg Val Cys Gly Asn Arg Lys Lys Pro Gly Ile Tyr Thr Arg 
 225                230                235                240
Val Ala Ser Tyr Ala Ala Trp Ile Asp Ser Val Leu Ala 
                 245                250



<210> 4095
<211> 3053
<212> DNA
<213> Rattus norvegicus
<308> M92340
<400> 4095

ccgtcctgt  ggggtacag  ccatcttga  taaggagca  cccttgcaa  atgtccgca  60
taaggatct  gctaatgca  gctttgctt  ttttcctca  tactgagtc  ataggtcaa  120
ttgtggaac  atgtggtta  atctaccct  agtttccag  tgtccagcg  ggctctaac  180
tcactgcca  ttgtgtgct  aaggagaag  gtctgcagg  gtactccgt  aatgccact  240
acatcgtgt  gaagacaaa  catgttgcc  ttcctaagg  gcaggtcac  gtcatcaac  300
gaacggcat  cagtgtcac  ttcacagac  tggtctttc  gaacgtcca  ctcacctgc  360
atatcctgt  atttggaca  atcgagcag  atgtgtatg  aatcaccat  ctttcaggc  420
atcctccag  tatacctac  aatttgagt  gcattgtga  tgaggggaa  aacatgctg  480
gtcagttgg  cccaggaag  gagacatac  ttgaaacaa  ctacacttt  aagtcagag  540
gggcaacag  gaagtttcc  gattgtcga  caaagcatg  cacgagctc  tgcatgatg  600
gctataccc  catctattt  gtcaacatc  aggtctggg  ggaggccga  aatgccctt  660
ggaatgtct  ctcagagcc  atcaatttt  accccgtgg  taaagtgaa  cccagccca  720
ctcataatt  gtcagtgac  aactcagaa  aattatcca  tatattaaa  ctagcatgg  780
tcaattcag  tttggacag  attttaagg  tgaagtcgg  catccaata  aggaccaaa  840
atgcctcaa  ttggattca  gtccctctt  aagatacag  gtctccccg  acttcgttc  900
ctgttcagg  tctcaagcc  tttacagaa  atgtgttta  gattcggtc  attaaggag  960
atgggaagg  ctactggag  gactggagt  aggaggcga  cgggaccac  tatgaagac  1020
gaccatcca  agcgccaag  ttctggtat  aggtaaatg  aaaccatcc  caggagtat  1080
ggtctgcac  gctcatatg  aagacattg  ccctttctg  agccaatgg  aagatcttg  1140
attatgaag  ggttcttac  cagtccaag  cagtttcgc  aacttacac  gttaacggc  1200
cagagttga  agtaaacct  accaataac  gctatgtag  gtctctagc  gcaagaaat  1260
tggtcggca  gtcccctgc  accgtcctc  ccatccccg  ctcccactt  aaagcttct  1320
accccgtag  ggatcttaa  gcatttcca  aagataacc  gctctgggt  gaatggaca  1380
cgccatcta  acctgtgaa  aaatacata  tagagtggt  tgtgttgtc  gagaactca  1440
cctgcatcc  agactggca  caagaagat  gcactgtga  tcggaccca  ttaagagga  1500
gcctactgg  gagcaagtg  tatctgatc  cagtaaccc  agtgtttcc  ggtgggcct  1560
gaagccctg  gtccatgaa  gcgtacctc  aacaagcag  tccttctaa  ggaccgact  1620
ttcggacaa  gaaagtggg  aaaaatgaa  ctgtcttag  gtgggacca  cttcctgtt  1680
atgtccaga  cggattcat  agaaactac  ccatatctt  tagaaccag  gttggaaaa  1740
aaatggttg  gcgtgtgga  tcttctcac  cagaataca  actgtcctc  ttgagtagc  1800
atacactgt  catggtcca  atggcagca  acacagaag  aggtgggaa  gatgggccg  1860
aattcactt  tacaacact  aagtttgct  aaggagaaa  cgaagccat  gtcgtgcct  1920
tgtgcttag  tttcctcct  acaacgctg  tgggagtct  gttctgctt  aataaacga  1980
acctaatta  aaaacacat  tggccgaat  tcccagatc  ttcaaagag  catattgcc  2040
agtggtcac  tcacacccc  ccaaggcac  attttaact  caaagatca  atgtactca  2100
atgccaatt  cactgacgt  agcgttgtg  aaatagaag  aaacaacaa  aagccttgt  2160
cagatgacc  gaaatcctt  gacctgttc  agaaggaga  aataagtac  gaagggcac  2220
gcagtggca  tggggggtc  tcgtgcatg  cctcttcta  gcccagcat  tccagcagt  2280
aggagaatg  gtctgctca  agcaccgca  gcaccgtgc  gtactccac  gtggtgcac  2340
gcggctaca  gcaccaggt  ccgtcagtg  aagtgttct  aaggtctga  tccacccag  2400
ccctgctag  ctccgagga  cggccagag  acctgcagc  ggtggatag  gtggacagc  2460
gtgacgaga  cttacccag  caacagtat  tcaaacaaa  ctgcagtca  cctggagcc  2520
gtccagatg  ttcacactt  ggaaggtca  gccaggttc  gtcaggcag  gaggaggat  2580
ttgtcagac  gaaacagca  caggtttca  atcacattt  agagcccta  ggctccgag  2640
aacggaggc  gtttcagga  ggttctgtg  cagatgctc  tggcacagg  actgatgga  2700
agatagaga  attcgaatc  gttggaatg  agacagcga  ggatgaaga  atttccaaa  2760
gttacttgc  acagactgt  agacaaggt  gctacatgc  acagtgagg  aaccggctc  2820
tgcgggacc  cagcgggac  gcgaagtaa  gctaaaatg  tcgtgactt  agatcggaa  2880
taagcttca  tccctgata  ccattgcct  taagaacaa  agtcacaac  gggccatct  2940
cattccaga  tatctggaa  tctccttcc  agcactacc  tgaacctga  tttatcctc  3000
gaatagctg  aggacgctg  gctgtttca  aatgtttgc  ctgctgaaa  cta  3053



<210> 4096
<211> 918
<212> PRT
<213> Rattus norvegicus
<308> P40190
<400> 4096

Met Ser Ala Leu Arg Ile Trp Leu Met Gln Ala Leu Leu Ile Phe Leu 
  1               5                  10                  15
Thr Thr Glu Ser Ile Gly Gln Leu Val Glu Pro Cys Gly Tyr Ile Tyr 
             20                  25                  30
Pro Glu Phe Pro Val Val Gln Arg Gly Ser Asn Phe Thr Ala Thr Cys 
         35                  40                  45
Val Leu Lys Glu Lys Cys Leu Gln Val Tyr Ser Val Asn Ala Thr Tyr 
     50                  55                  60
Ile Val Trp Lys Thr Asn His Val Ala Val Pro Lys Glu Gln Val Thr 
 65                  70                  75                  80
Val Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Val Val Phe 
                 85                  90                  95
Gln Asn Val Gln Leu Thr Cys Asn Ile Leu Ser Phe Gly Gln Ile Glu 
             100                105                110
Gln Asn Val Tyr Gly Ile Thr Ile Leu Ser Gly Tyr Pro Pro Asp Ile 
         115                120                125
Pro Thr Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Asn Met Leu Cys 
     130                135                140
Gln Leu Asp Pro Gly Arg Glu Thr Tyr Leu Glu Thr Asn Tyr Thr Leu 
 145                150                155                160
Lys Ser Glu Trp Ala Thr Glu Lys Phe Pro Asp Cys Arg Thr Lys His 
                 165                170                175
Gly Thr Ser Ser Cys Met Met Gly Tyr Thr Pro Ile Tyr Phe Val Asn 
             180                185                190
Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Asn Val Ser Ser 
         195                200                205
Glu Pro Ile Asn Phe Asp Pro Val Asp Lys Val Lys Pro Ser Pro Pro 
     210                215                220
His Asn Leu Ser Val Thr Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys 
 225                230                235                240
Leu Ala Trp Val Asn Ser Gly Leu Asp Ser Ile Leu Arg Leu Lys Ser 
                 245                250                255
Asp Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ile Gln Val Pro 
             260                265                270
Leu Glu Asp Thr Val Ser Pro Arg Thr Ser Phe Thr Val Gln Asp Leu 
         275                280                285
Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Ser Ile Lys Glu Asn 
     290                295                300
Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Thr Thr 
 305                310                315                320
Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Val Asn 
                 325                330                335
Ala Asn His Pro Gln Glu Tyr Arg Ser Ala Arg Leu Ile Trp Lys Thr 
             340                345                350
Leu Pro Leu Ser Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Val 
         355                360                365
Leu Thr Gln Ser Lys Ser Val Ser Gln Thr Tyr Thr Val Asn Gly Thr 
     370                375                380
Glu Leu Ile Val Asn Leu Thr Asn Asn Arg Tyr Val Ala Ser Leu Ala 
 385                390                395                400
Ala Arg Asn Val Val Gly Lys Ser Pro Ala Thr Val Leu Thr Ile Pro 
                 405                410                415
Gly Ser His Phe Lys Ala Ser His Pro Val Val Asp Leu Lys Ala Phe 
             420                425                430
Pro Lys Asp Asn Leu Leu Trp Val Glu Trp Thr Pro Pro Ser Lys Pro 
         435                440                445
Val Asn Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Glu Asn Ser Pro 
     450                455                460
Cys Ile Pro Asp Trp Gln Gln Glu Asp Gly Thr Val Asn Arg Thr His 
 465                470                475                480
Leu Arg Gly Ser Leu Leu Glu Ser Lys Cys Tyr Leu Ile Thr Val Thr 
                 485                490                495
Pro Val Phe Pro Gly Gly Pro Gly Ser Pro Glu Ser Met Lys Ala Tyr 
             500                505                510
Leu Lys Gln Ala Ala Pro Ser Lys Gly Pro Thr Val Arg Thr Lys Lys 
         515                520                525
Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp His Leu Pro Val Asp 
     530                535                540
Val Gln Asn Gly Phe Ile Arg Asn Tyr Ser Ile Ser Tyr Arg Thr Ser 
 545                550                555                560
Val Gly Lys Glu Met Val Val Arg Val Asp Ser Ser His Thr Glu Tyr 
                 565                570                575
Thr Leu Ser Ser Leu Ser Ser Asp Thr Leu Tyr Met Val His Met Ala 
             580                585                590
Ala Tyr Thr Glu Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr 
         595                600                605
Thr Leu Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro Val 
     610                615                620
Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys Phe 
 625                630                635                640
Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp 
                 645                650                655
Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg 
             660                665                670
His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Ala Asn Phe Thr 
         675                680                685
Asp Val Ser Val Val Glu Ile Glu Ala Asn Asn Lys Lys Pro Cys Pro 
     690                695                700
Asp Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Ser Thr 
 705                710                715                720
Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser Ser 
                 725                730                735
Arg Pro Ser Ile Ser Ser Ser Glu Glu Asn Glu Ser Ala Gln Ser Thr 
             740                745                750
Ala Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg His 
         755                760                765
Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln Pro 
     770                775                780
Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp Ser 
 785                790                795                800
Val Asp Ser Gly Asp Glu Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln 
                 805                810                815
Ser Cys Ser Gln Pro Gly Ala Ser Pro Asp Val Ser His Phe Gly Arg 
             820                825                830
Ser Ser Gln Val Pro Ser Gly Ser Glu Glu Asp Phe Val Arg Leu Lys 
         835                840                845
Gln Gln Gln Val Ser Asp His Ile Ser Glu Pro Tyr Gly Ser Glu Gln 
     850                855                860
Arg Arg Leu Phe Gln Glu Gly Ser Val Ala Asp Ala Leu Gly Thr Gly 
 865                870                875                880
Thr Asp Gly Gln Ile Glu Arg Phe Glu Ser Val Gly Met Glu Thr Ala 
                 885                890                895
Met Asp Glu Asp Ile Ser Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
             900                905                910
Gly Gly Tyr Met Pro Gln 
         915



<210> 4097
<211> 150
<212> DNA
<213> Homo sapiens
<308> S80479
<400> 4097

accccaaag  ttgaattaa  aaacacatc  ggcctaatg  tccagatcc  tcaaagagt  60
atattgccc  gtggtcacc  cacactcct  caaggcaca  ttttaattc  aaagatcaa  120
tgtattcag  tggcaattt  actgatgtaa  150



<210> 4098
<211> 918
<212> PRT
<213> Homo sapiens
<308> P40189
<400> 4098

Met Leu Thr Leu Gln Thr Trp Val Val Gln Ala Leu Phe Ile Phe Leu 
  1               5                  10                  15
Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
             20                  25                  30
Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
         35                  40                  45
Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
     50                  55                  60
Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
 65                  70                  75                  80
Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                 85                  90                  95
Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
             100                105                110
Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
         115                120                125
Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
     130                135                140
Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
 145                150                155                160
Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                 165                170                175
Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
             180                185                190
Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
         195                200                205
Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
     210                215                220
Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
 225                230                235                240
Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                 245                250                255
Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
             260                265                270
Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
         275                280                285
Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
     290                295                300
Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
 305                310                315                320
Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                 325                330                335
Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
             340                345                350
Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
         355                360                365
Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
     370                375                380
Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
 385                390                395                400
Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                 405                410                415
Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
             420                425                430
Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
         435                440                445
Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
     450                455                460
Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
 465                470                475                480
Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                 485                490                495
Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
             500                505                510
Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
         515                520                525
Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
     530                535                540
Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
 545                550                555                560
Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                 565                570                575
Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
             580                585                590
Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
         595                600                605
Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
     610                615                620
Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
 625                630                635                640
Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                 645                650                655
Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
             660                665                670
Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
         675                680                685
Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
     690                695                700
Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
 705                710                715                720
Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                 725                730                735
Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
             740                745                750
Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
         755                760                765
His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
     770                775                780
Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
 785                790                795                800
His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                 805                810                815
Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
             820                825                830
Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
         835                840                845
Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
     850                855                860
Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
 865                870                875                880
Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                 885                890                895
Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
             900                905                910
Gly Gly Tyr Met Pro Gln 
         915



<210> 4099
<211> 4645
<212> DNA
<213> Rattus norvegicus
<308> M93017
<400> 4099

tccctgcca  catcctgct  gttccctcc  gacgcggct  ggctccgtg  ggcgccacc  60
tgccgccag  agcgcccgt  gcccgaggc  cgtggggcg  ccccgcagc  ccgcgatgt  120
gccgtggct  acactaaag  ctttgtagc  atcaaccag  gtgcagttt  gatggaaaa  180
gaaggttgc  cgatttcaa  agatcccta  tgttgaaaa  gagacaatg  tccctgtac  240
gacatccaa  agagcaagt  agttagcag  cagtgaggt  gcaggcctt  tccaggctg  300
tcttcagaa  ggcttaaac  aatctgaag  tagtcatag  cgagccttc  atggctgga  360
tgagtttga  atcagtgaa  atgaaccat  atggaagaa  tacatttct  agtttaaaa  420
tcccctcat  atgctgctt  tggcttcgg  agtcatcag  gttttaatg  gtcagtttg  480
tgatgccgt  agtatcact  tggcaatac  gattgttgt  accgtggcc  ttgttcagg  540
atatcgttc  gaaaaatct  tagaagaat  aagtaaact  gtgccacca  aatgccatt  600
tgttcgtga  ggaaaattg  agcatacac  tgcccgaga  ttggttcca  gtgatacag  660
ttgtctgtc  gtgggggac  gagttcctg  tgacttacg  ttattcgag  ccgtggatc  720
ttccatcga  gagtctagc  tgacaggag  gacaactcc  tgttctaag  tgaccgctc  780
tcaaccagc  gctaccaat  gggatcttg  atcaagaag  aacattgcc  tcatgggga  840
tctggtcag  tgtggcaaa  caaagggta  tgtcattgg  acaggagag  attctgaat  900
tggagaggt  tttaagatg  tgcaggcag  agaagcacc  aaaacgcct  tgcagaaga  960
catggacct  ttgggcaag  agctgtcct  ttactcctt  ggtataata  gtatcatca  1020
gttggttgg  tggttacta  ggaaagaca  tctggaaat  ttcactatt  gtgtaagtt  1080
ggctgtagc  gcaattcct  aaggtctgc  tattgtggt  acagtgaca  tagcccttg  1140
tgttatgag  atggtgaag  aaagggcta  tgtaaagaa  ttgcctatt  ttgaaacgc  1200
gggctgctg  aatgtgatt  gttcagata  aactggaac  ctgacgaag  atgagatga  1260
tgttactca  atcctcact  cagacggcc  gcatgctga  gttactgga  ttggctaca  1320
tcagtttgg  gaagtgatt  ttgatggtg  tgttgttca  ggattctat  acccagctg  1380
tagcagaat  gttgaggcg  gctgtgtgt  caacgatgc  gtcattagg  acaacactc  1440
gatgggaaa  ccaactgaa  gagccttaa  cgctctcgc  atgaagatg  gtcttgatg  1500
actgcaaca  gactatatc  gaaaagctg  atacccttt  agttctgag  agaaatgga  1560
ggctgttaa  tgtgtgcac  gaacacagc  ggacagacc  gagatttgt  ttatgaagg  1620
tgcttatga  caggtgatt  agtattgta  tacgtacaa  agcaaaggg  agactttgg  1680
acttaccca  cagcagaga  atttgtacc  acaagagaa  gcccagatg  gctcggcag  1740
actccgagt  cttgcactg  cgtctggtc  ggacctggg  cagctgacc  tccttggcc  1800
ggtaggaat  attgaccct  cgagaactg  tgtgaaaga  gccgtcaca  cactcattg  1860
ctcaggagt  tccatcaaa  tgatcacag  agactctca  gagactgca  ttgcaatcg  1920
tagtcgtct  ggattgtat  ctaaaactt  acagtctgt  tctggagaa  aagtagata  1980
aatggaagt  cagcacctt  cacagatag  gccaaaggt  gcagtattt  acagagcaa  2040
cccaagaca  aagatgaaa  ttatcaagt  tctacaaaa  aacgggtca  ttgtagcca  2100
gacaggaga  ggggtaaat  atgcagtgg  tctgaaggc  gcagatatt  gagttgcaa  2160
gggccagac  ggcacagat  tttgcaaag  ggctgcgga  atgatcttg  tggatgatg  2220
tttccaaac  ataatgtct  caatagaag  gggtaaagg  atttataat  acattaaaa  2280
ttttgttag  tttcaactg  gcacgagta  agcagcatt  actttaatc  cattggcta  2340
gttaatgaa  tttcctaac  ctctcaatg  aatgcagat  ttgtggatc  atattataa  2400
ggatggacc  ccagctcag  gccttggag  agagccagt  gataaagat  tcattcgaa  2460
accccctcg  aactggaag  acagcattt  gacaaaaaa  ttgatcctt  aaatacttg  2520
ttcatcaat  atcattgtc  gtgggactt  gtttgtctt  tggcgagag  ttcgagaca  2580
tgtgataac  ccccgagac  caacaatga  tttcacttg  ttcgtgttt  ttgatatgt  2640
caatgcact  agttccaga  ctcagacta  gtctgtgtt  gagattgga  tctgcagta  2700
taagatgtt  tgctatgcg  ttcttggat  catcatggg  cagttgctt  ttatctact  2760
cccgcctct  cagaaggtt  ttcagaccg  gagcctcag  attctggat  tgttgtttc  2820
tttgggtct  acttcatca  tgtgcattg  gtctgaaat  ataaagaag  ttgaaagga  2880
cagggaaaa  actcagaag  acactactt  aacaccatc  tcttttctt  aagtatgat  2940
catattgca  ttttttttt  atttgcaaa  taggaattg  agtctggga  tcatttaga  3000
gggcaagtt  aagaggata  tgaagattt  aggactttt  aactttcca  tgactaaaa  3060
tgaccatta  tgttaaaga  ttgatttga  ccttgttgg  agtcccaaa  gaaattatg  3120
aactttgaa  aacacgttc  ttgatttga  ttggctttt  caatcgatt  gaacttcaa  3180
atatggtca  gtactgaat  aaaaaagta  aaaaggcaa  acgtgaaca  cttctgcac  3240
tagagttct  atgtacaaa  acactatct  tcttagatg  atataaata  tttttttat  3300
tttaaatat  gtactattt  tggttgtgg  gctttctta  taatacact  aataaatgc  3360
ctcagtcat  tcaaaggca  tctatttgg  ttagaaatt  ccaggagtg  catatttca  3420
ctaccatgt  tcctttttc  tgcaatgta  gcaaatgat  ccttgtgct  ccattttta  3480
atttcaagt  ttttatttt  tatttttgc  caggatgtg  ccactgtct  atcactgtt  3540
tttcttttt  tgactgaaa  gcatatact  caattgaag  aaatgtttg  tcttcttag  3600
aagtgtaca  ggttgtttt  gttttttgt  gtggttttc  acagaggtg  gagtctttg  3660
cctagcagg  ttagttcag  ctgttgttg  attacagtt  gagtaattg  acttaacac  3720
gtcaaagag  caaaaacaa  aaaggccgg  tggaatttc  aacagacta  gttaacacg  3780
ccttgttta  gttaataca  ttctacttt  tcagtgtca  cttgtcatt  cttctttat  3840
aatcaaaca  ttcagctaa  taattgacc  ttattactg  ttcatattt  tatttttaa  3900
tctatttct  agagagtat  gactaccat  cttagaaaa  caaaagtcc  aaactcaga  3960
agataggac  tgaaccagg  tgtccatca  aagatcctg  gcaggcctt  ctcctccga  4020
tcctctagg  agccgcttt  gcctagatt  tagcacaac  ctgagtctg  cccttctgc  4080
gtttgttgg  atccgtctt  ttcttttgg  atgcttggg  aatagatgg  tttgctttg  4140
gtaaaccat  agtttttat  agagcttga  aaaataaag  taagtgttg  atcttgtat  4200
tcataaact  tcagaatta  ctgttctga  cttgttcaa  attactggt  agtgttaac  4260
ctgctgcgc  gtcgttgat  ggagaactc  gttgtctga  tctgtacta  tgaagcatg  4320
acgtaagga  ccagatgtc  gactttgtc  taatctctc  ggctcaact  tcagtgtac  4380
ttgttctgt  tcattaggt  ggacgtgag  tcactgtca  ccaactcat  gaggtttga  4440
gtctcatag  aaaatttta  aatggtttt  tacattctg  tccaaactt  aaaactaca  4500
attaagtgc  tattcagtc  tgtttgttt  acagtagag  ttgagaata  gactcatga  4560
atgaatgtg  ctatctttt  acttggtat  gaactataa  aataaagtg  gtttttcat  4620
agttcaaaa  aaaaaaaaa  aaaaa  4645



<210> 4100
<211> 919
<212> PRT
<213> Rattus norvegicus
<308> Q64566
<400> 4100

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Val Glu Asn Glu Thr 
  1               5                  10                  15
Met Ile Pro Val Leu Thr Ser Lys Arg Ala Ser Glu Leu Ala Val Ser 
             20                  25                  30
Glu Val Ala Gly Leu Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
         35                  40                  45
Ser Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
     50                  55                  60
Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
 65                  70                  75                  80
Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                 85                  90                  95
Met Arg Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
             100                105                110
Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
         115                120                125
Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
     130                135                140
Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
 145                150                155                160
Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                 165                170                175
Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
             180                185                190
Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
         195                200                205
Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
     210                215                220
Cys Gly Lys Ala Lys Gly Ile Val Ile Gly Thr Gly Glu Asn Ser Glu 
 225                230                235                240
Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                 245                250                255
Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
             260                265                270
Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
         275                280                285
Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
     290                295                300
Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
 305                310                315                320
Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                 325                330                335
Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
             340                345                350
Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Leu Thr Ser 
         355                360                365
Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
     370                375                380
Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
 385                390                395                400
Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                 405                410                415
Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
             420                425                430
Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
         435                440                445
Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
     450                455                460
Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
 465                470                475                480
Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Asn Ser Lys 
                 485                490                495
Gly Gln Thr Leu Ala Leu Thr Gln Gln Gln Arg Asp Leu Tyr Gln Gln 
             500                505                510
Glu Lys Ala Gln Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
         515                520                525
Ser Gly Pro Asp Leu Gly Gln Leu Thr Leu Leu Gly Leu Val Gly Ile 
     530                535                540
Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
 545                550                555                560
Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                 565                570                575
Ala Ile Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
             580                585                590
Ser Val Ser Gly Glu Glu Val Asp Thr Met Glu Val Gln His Leu Ser 
         595                600                605
Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
     610                615                620
Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
 625                630                635                640
Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                 645                650                655
Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
             660                665                670
Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
         675                680                685
Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
     690                695                700
Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
 705                710                715                720
Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                 725                730                735
Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
             740                745                750
Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
         755                760                765
Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
     770                775                780
Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
 785                790                795                800
Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                 805                810                815
Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
             820                825                830
Val Phe Glu Ile Gly Leu Cys Ser Asn Lys Met Phe Cys Tyr Ala Val 
         835                840                845
Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
     850                855                860
Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
 865                870                875                880
Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ser Glu Ile Ile Lys 
                 885                890                895
Lys Val Glu Arg Ser Arg Glu Lys Thr Gln Lys Asn Thr Thr Ser Thr 
             900                905                910
Pro Ser Ser Phe Leu Glu Val 
         915



<210> 4101
<211> 3458
<212> DNA
<213> Homo sapiens
<308> AF225981
<400> 4101

cttcctccc  cccgctcgc  tcttctcac  ccgggagca  gctcgcgcc  cgcaccgct  60
ccccgcgag  agctcctct  ctcccgagg  gcgcggggc  cccccgcga  ccccgcggc  120
gagaccccg  agcctggag  agggctgtc  ggggctttg  gttgcacgt  ttcaaaaaa  180
acctaatgg  gaaaatgag  caatgattc  tgtattgac  tcaaaaaaa  caagtgaat  240
accagtcag  gaagttgca  gcattctcc  agctgatct  cagaatggt  taaacaaat  300
tgaagttag  cataggcga  cctttcatg  ctggaatga  tttgatatt  gtgaagatg  360
gccactgtg  aagaagtat  tttctcagt  taaaaatcc  cttattatg  tgcttctgg  420
ttctgcagt  atcagtgtt  taatgcatc  gtttgatga  gccgtcagt  tcactgtgg  480
aatactatt  gttgttaca  ttgcctttg  tcaggaata  cgttcagaa  aatctcttg  540
agaattgag  aaacttgtg  caccagaat  ccattgtgt  cgtgaagga  aattggagc  600
tacacttgc  cgagacttg  ttccaggtg  tacagtttg  ctttctgtt  gggatagag  660
tcctgctga  ttacgcttg  ttgaggctg  ggatctttc  attgatgag  ccagcttga  720
aggtgagac  acgccttgt  ctaaggtga  agctcctca  ccagctgca  ctaatggag  780
tcttgcatc  agaagtaac  ttgccttta  gggaacact  gtcagatgt  gcaaagcaa  840
gggtgttgt  attggaaca  gagaaaatt  tgaatttgg  gaggttttt  aaatgatgc  900
agcagaaga  gcaccaaaa  cccctctgc  gaagagcat  gacctctta  gaaaacaac  960
ttcctttta  tcctttggt  taataggaa  catcatgtt  gttggctgg  tactgggaa  1020
agatatcct  gaaatgttt  ctattagtg  aagtttggc  gtagcagca  ttcctgaag  1080
tctccccat  gtggtcaca  tgacgctag  tcttggtgt  atgagaatg  tgaagaaaa  1140
ggccattgt  aaaaagctg  ctattgttg  aactctggg  tgctgtaat  tgatttgtt  1200
agataaaac  ggaacactg  cgaagaatg  aatgactgt  actcacata  ttacttcag  1260
tggtctgca  gctgaggtt  ctggagttg  ctataatca  tttggggaa  tgattgttg  1320
tggtgatgt  gttcatgga  tctataacc  agctgttag  agaattgtt  aggcgggct  1380
tgtgtgcaa  gatgctgta  ttagaaaca  tactctaat  gggaagcca  cagaagggg  1440
cttaattgc  cttgcaatg  agatgggtc  tgatggact  caacaagac  acatcagaa  1500
agctgaata  ccttttagc  ctgagcaaa  gtggatggc  gttaagtgt  tacaccgaa  1560
acagcagga  agaccagag  tttgtttta  gaaaggtgc  tacgaacaa  taattaagt  1620
ctgtactac  taccagagc  aagggcaga  cttgacact  actcagcag  agagagatg  1680
gtaccaaca  gagaaggca  gcatgggct  agcgggact  agagttctt  ctttggctt  1740
tggtcctga  ctgggacag  tgacatttc  tggcttggt  ggaatcatt  atccaccta  1800
aactggtgt  aaagaagct  ttacaacac  cattgcctc  ggagtatca  taaaaatga  1860
tactggaga  tcacaggag  ctgcagttg  aatcgccag  cgtctggga  tgtattcca  1920
aacttccca  tcagtctca  gagaagaaa  agatgcaat  gatgttcag  agctttcac  1980
aatagtacc  aaggttgca  tattttaca  agctagccc  aggcacaag  tgaaaatta  2040
taagtcgct  cagaagaac  gttcagttg  agccatgac  ggagatgga  taaatgatg  2100
agttgctct  aaggctgca  acattggag  tgcgatggg  cagactggt  cagatgttt  2160
caaagaggc  gcagacatg  tcctagtgg  tgatgattt  caaaccata  tgtctgcaa  2220
cgaagaggg  aaagggatt  ataataaca  taaaaattt  gttagattc  agctgagca  2280
gagtatagc  gcattaact  taatctcat  ggctacatt  atgaacttt  ctaatcctc  2340
caatgccat  cagattttg  ggatcaata  tattatgga  ggaccccca  ctcagagcc  2400
tggagtaga  ccagtggat  aagatgtca  tcgtaaacc  cctcgcaac  ggaaagaca  2460
cattttgac  aaaaacttg  tacttaaaa  acttgtttc  tcaataatc  ttgtttgtg  2520
gactttgtt  gtcttctgg  gtgagctac  agacaatgt  attacacct  gagacacaa  2580
aatgacctt  acatgcttt  tgttttttg  catgttcaa  gcactaagt  ccagatccc  2640
gaccaagtc  gtgtttgag  ttggactct  cagtaatag  atgttttgc  atgcagttc  2700
tggatccat  atgggacaa  tactagtta  ttactttcc  ccgcttcag  aggtttttc  2760
gactgagag  ctaagcata  tggatctgt  gtttctttt  ggtctcacc  catcagtgt  2820
catagtggc  gaaattata  agaaggttg  aaggagcag  gaaaagatc  agaagcatg  2880
ctggctctg  gagaggagt  gacagcagc  ggttgagat  catccccat  tggagacag  2940
actgccact  acagaagat  tgagctgtg  ctaagtcca  tcttgtgcc  agccgtgtc  3000
gcgccttca  tctttggaa  tctgcatac  acatcttag  accatcttc  tgcagctct  3060
ccttaccta  ataaagaaa  agcccaagg  cagtatttc  aaaagcact  taacagctt  3120
tcattttct  cacatatac  acaaattct  taaagaaag  aattaattt  aaaaaacta  3180
gatgttttt  tcttctggc  tcataaatg  cttgctgta  aaattgaaa  attgatact  3240
aactgtctt  ttaatgatg  cctaacttt  ttcaaccca  cggaattta  tttttccct  3300
aaataagat  ttttccact  gtctactac  tgaccataa  catgtctgc  tttgaattc  3360
ctaaaccct  aatctgtgt  tatgaaaaa  acaaatgac  attaaatat  attctcttt  3420
ctgttctct  tcaccgaaa  aaaaaaaaa  aaaaaaaa  3458



<210> 4102
<211> 919
<212> PRT
<213> Homo sapiens
<308> P98194
<400> 4102

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
  1               5                  10                  15
Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
             20                  25                  30
Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
         35                  40                  45
Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Lys Phe Asp 
     50                  55                  60
Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
 65                  70                  75                  80
Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                 85                  90                  95
Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
             100                105                110
Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
         115                120                125
Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
     130                135                140
Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
 145                150                155                160
Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                 165                170                175
Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
             180                185                190
Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
         195                200                205
Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
     210                215                220
Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
 225                230                235                240
Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                 245                250                255
Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
             260                265                270
Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
         275                280                285
Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
     290                295                300
Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
 305                310                315                320
Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                 325                330                335
Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
             340                345                350
Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
         355                360                365
Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
     370                375                380
Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
 385                390                395                400
Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                 405                410                415
Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
             420                425                430
Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
         435                440                445
Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
     450                455                460
Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
 465                470                475                480
Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                 485                490                495
Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
             500                505                510
Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
         515                520                525
Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
     530                535                540
Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
 545                550                555                560
Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                 565                570                575
Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
             580                585                590
Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
         595                600                605
Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
     610                615                620
Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
 625                630                635                640
Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                 645                650                655
Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
             660                665                670
Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
         675                680                685
Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
     690                695                700
Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
 705                710                715                720
Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                 725                730                735
Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
             740                745                750
Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
         755                760                765
Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
     770                775                780
Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
 785                790                795                800
Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                 805                810                815
Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
             820                825                830
Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
         835                840                845
Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
     850                855                860
Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
 865                870                875                880
Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                 885                890                895
Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
             900                905                910
Ser Ser Ser Phe Leu Glu Val 
         915



<210> 4103
<211> 307
<212> DNA
<213> Rattus norvegicus
<308> M93257
<400> 4103

aagtcagca  actgtaaat  ttccagacg  ccaaaataa  agcagaggc  cagagacag  60
actgtacta  tgtccccag  agctcacac  acatctcat  tgaagaatg  gtacaagct  120
tccaggtat  gtggtgacg  ctgtcatcc  cagtatcca  gaggcagag  catcggagt  180
cagcgccag  ctggtctac  taagtgagt  ccaagacag  cagggctac  tagaaatac  240
ttttaaaga  agttataac  tcttttata  tataaaaga  attaaagat  tacatattt  300
gatacaa  307



<210> 4104
<211> 264
<212> PRT
<213> Rattus norvegicus
<308> CAA78276
<400> 4104

Met Pro Leu Ala Ala Val Ser Leu Gly Leu Leu Leu Leu Ala Leu Leu 
  1               5                  10                  15
Leu Leu Leu Arg His Leu Gly Trp Gly Leu Val Thr Ile Phe Trp Phe 
             20                  25                  30
Glu Tyr Val Leu Gln Pro Val His Asn Leu Ile Met Gly Asp Thr Lys 
         35                  40                  45
Glu Gln Arg Ile Leu Arg Tyr Val Gln Gln Asn Ala Lys Pro Gly Asp 
     50                  55                  60
Pro Gln Ser Val Leu Glu Ala Ile Asp Thr Tyr Cys Thr Gln Lys Glu 
 65                  70                  75                  80
Trp Ala Met Asn Val Gly Asp Ala Lys Gly Gln Ile Met Asp Ala Val 
                 85                  90                  95
Ile Arg Glu Tyr Ser Pro Ser Leu Val Leu Glu Leu Gly Ala Tyr Cys 
             100                105                110
Gly Tyr Ser Ala Val Arg Met Ala Arg Leu Leu Gln Pro Gly Ala Arg 
         115                120                125
Leu Leu Thr Met Glu Met Asn Pro Asp Tyr Ala Ala Ile Thr Gln Gln 
     130                135                140
Met Leu Asn Phe Ala Gly Leu Gln Asp Lys Val Thr Ile Leu Asn Gly 
 145                150                155                160
Ala Ser Gln Asp Leu Ile Pro Gln Leu Lys Lys Lys Tyr Asp Val Asp 
                 165                170                175
Thr Leu Asp Met Val Phe Leu Asp His Trp Lys Asp Arg Tyr Leu Pro 
             180                185                190
Asp Thr Leu Leu Leu Glu Lys Cys Gly Leu Leu Arg Lys Gly Thr Val 
         195                200                205
Leu Leu Ala Asp Asn Val Ile Val Pro Gly Thr Pro Asp Phe Leu Ala 
     210                215                220
Tyr Val Arg Gly Ser Ser Ser Phe Glu Cys Thr His Tyr Ser Ser Tyr 
 225                230                235                240
Leu Glu Tyr Met Lys Val Val Asp Gly Leu Glu Lys Ala Ile Tyr Gln 
                 245                250                255
Gly Pro Ser Ser Pro Asp Lys Ser 
             260



<210> 4105
<211> 507
<212> DNA
<213> Rattus norvegicus
<308> M93297
<400> 4105

tttagattt  tttgtttac  ttgagtgtt  tgcctacct  tatgtatgc  ccatgtggg  60
gctgggagt  aaacgcaga  ctctgggaa  gcagcaagt  ttccagact  ctaagccgt  120
tctcccacc  ctcataatt  attctcaac  ggcagttgc  aaacaaata  aaagaagct  180
ttaaaactc  tgtttcttt  gtagcgtgc  cttcaggat  ccaatgttg  tgctttcat  240
gtggagccc  tccagggtg  agcgggtgt  atcgttcca  atccaggat  cctgacggg  300
gttcgagaa  tttgcaccc  gcaccaggt  gtcccactc  ctttgcagt  acgccaggc  360
cgcctgcac  tgtttggac  ctgctgaca  gctagatga  ggattccaa  gcttgagga  420
catgctaat  cttgcacct  ctgaggaac  cgctaatgc  tgcaccctc  gaggaacat  480
ctaaatgct  gcaccttct  aggaaca  507



<210> 4106
<211> 223
<212> PRT
<213> Rattus norvegicus
<308> AAA42061
<400> 4106

Arg Ala Leu Gln Asp Pro Asn Val Ala Ala Phe Met Val Glu Pro Ile 
  1               5                  10                  15
Gln Gly Glu Ala Gly Val Ile Val Pro Asp Pro Gly Tyr Leu Thr Gly 
             20                  25                  30
Val Arg Glu Leu Cys Thr Arg His Gln Val Leu Phe Ile Ala Asp Glu 
         35                  40                  45
Ile Gln Thr Gly Leu Ala Arg Thr Gly Arg Trp Leu Ala Val Asp His 
     50                  55                  60
Glu Asn Val Arg Pro Asp Ile Val Leu Leu Gly Lys Ala Leu Ser Gly 
 65                  70                  75                  80
Gly Leu Tyr Pro Val Ser Ala Val Leu Cys Asp Asp Asp Ile Met Leu 
                 85                  90                  95
Thr Ile Lys Pro Gly Glu His Gly Ser Thr Tyr Gly Gly Asn Pro Leu 
             100                105                110
Gly Cys Arg Ile Ala Ile Ala Ala Leu Glu Val Leu Glu Glu Glu His 
         115                120                125
Leu Ala Glu Asn Ala Asp Lys Met Gly Ala Ile Leu Arg Lys Glu Leu 
     130                135                140
Met Lys Leu Pro Ser Asp Val Val Thr Ala Val Arg Gly Lys Gly Leu 
 145                150                155                160
Leu Asn Ala Ile Val Ile Arg Glu Thr Lys Asp Cys Asp Ala Trp Lys 
                 165                170                175
Val Cys Leu Arg Leu Arg Asp Asn Gly Leu Leu Ala Lys Pro Thr His 
             180                185                190
Gly Asp Ile Ile Arg Leu Ala Pro Pro Leu Val Ile Lys Glu Asp Glu 
         195                200                205
Ile Arg Glu Ser Val Glu Ile Ile Asn Lys Thr Ile Leu Ser Phe 
     210                215                220



<210> 4107
<211> 2013
<212> DNA
<213> Homo sapiens
<308> NM_000274
<400> 4107

aattcctgt  ctcaggcgc  gtcagatct  tggtttttc  acttgaagg  cacaatgtt  60
tccaaacta  cacatttgc  gaggtttgc  gtacttagt  gcggagttc  ttcttcagt  120
gcttctgct  catctgttg  aactaaaaa  acagtccaa  gccctccaa  ctctgatga  180
atttttgaa  gggaatata  gtatggtgc  cacaactac  atcctttac  tgtagccct  240
gagagagga  aaggtattt  cttatggga  gtagaaggc  gaaaatatt  tgacttcct  300
agttcttac  gtgctgtca  ccaagggca  tgtcacccc  agattgtga  tgctctgaa  360
agtcaagtg  acaaattga  cttaacatc  agagctttc  ataataacg  acttggtga  420
tatgaggag  atattacta  acttttcaa  taccacaaa  ttcttccta  gaatacagg  480
gtggaggct  gagagactg  ctgtaaact  gctcgtaag  ggggctata  cgtgaaggg  540
attcagaaa  acaaagcaa  gattgtttt  gcagctggg  acttctggg  taggacgtt  600
tctgctatc  ccagttcca  agacccaac  agttacgat  gttttggac  atttatgcc  660
ggattcgac  tcattccct  taatgatct  cccgcactg  agcgtgctc  tcaggatcc  720
aatgtggct  cgttcatgg  agaaccaat  cagggtgaa  caggcgttg  tgttccgga  780
ccaggttac  taatgggag  gcgagagct  tgcaccagg  accaggttc  ctttattgc  840
gatgaaata  agacaggat  ggccagaac  ggtagatgg  tggctgttg  ttatgaaaa  900
gtcagacct  atatagtcc  ccttggaaa  gccctttct  ggggcttat  ccctgtgtc  960
gcagtgctg  gtgatgatg  catcatgct  accattaag  caggggagc  tgggtccac  1020
tacggtggc  atccactag  ctgccgagt  gccatcgca  cccttgagg  tttagaaga  1080
gaaaacctt  ctgaaaatg  agacaaatt  ggcattatc  tgagaaatg  actcatgaa  1140
ctaccttct  atgttgtaa  tgccgtaag  ggaaaagga  tattaaacg  tattgtcat  1200
aaagaaacc  aagattggg  tgcttggaa  gtgtgtcta  gacttcgag  taatggact  1260
ctggccaag  caacccatg  cgacattat  aggtttgcg  ctccgctgg  gatcaagga  1320
gatgagctt  gagagtcca  tgaaattat  aacaagacc  tcttgtctt  ctgagggta  1380
ccagctgtt  tcagtggtc  ctgggagcc  gctggagac  ggtggtcct  taaaagctt  1440
attcctaat  tgggcacat  ccactccca  gagtcttca  aaacttttt  tttgaatat  1500
tttttttca  ttgatacat  atagaacaa  gtttatgaa  ctgccgttt  ctttgtaac  1560
taactaaat  atgtaatgg  atctatatt  agttgaagt  ttttgatgt  catgtgtac  1620
tcctaaggt  aaatgcatc  atatacaga  agcctctaa  tcaagtcct  cagtataat  1680
gatatatgt  tttataatt  cctcactgg  ataagtgtt  catatttga  aaagttatc  1740
ctgggtatt  cataaaagg  ttcatctta  aaagtgaaa  cattgttat  gaattttag  1800
aaggattaa  ggttaagtg  atataaaat  ctaatatta  gtaaacttc  tattggcca  1860
caccagggt  gtattctat  gatgtcatt  ttttgaatt  agaattagt  tttaacatt  1920
ctaaattgt  ttgagtgct  gattataat  tgtaaaaaa  gtttatttt  aatacttct  1980
taaatttaa  ataaagctt  tatttcaaa  gtc  2013



<210> 4108
<211> 439
<212> PRT
<213> Homo sapiens
<308> P04181
<400> 4108

Met Phe Ser Lys Leu Ala His Leu Gln Arg Phe Ala Val Leu Ser Arg 
  1               5                  10                  15
Gly Val His Ser Ser Val Ala Ser Ala Thr Ser Val Ala Thr Lys Lys 
             20                  25                  30
Thr Val Gln Gly Pro Pro Thr Ser Asp Asp Ile Phe Glu Arg Glu Tyr 
         35                  40                  45
Lys Tyr Gly Ala His Asn Tyr His Pro Leu Pro Val Ala Leu Glu Arg 
     50                  55                  60
Gly Lys Gly Ile Tyr Leu Trp Asp Val Glu Gly Arg Lys Tyr Phe Asp 
 65                  70                  75                  80
Phe Leu Ser Ser Tyr Ser Ala Val Asn Gln Gly His Cys His Pro Lys 
                 85                  90                  95
Ile Val Asn Ala Leu Lys Ser Gln Val Asp Lys Leu Thr Leu Thr Ser 
             100                105                110
Arg Ala Phe Tyr Asn Asn Val Leu Gly Glu Tyr Glu Glu Tyr Ile Thr 
         115                120                125
Lys Leu Phe Asn Tyr His Lys Val Leu Pro Met Asn Thr Gly Val Glu 
     130                135                140
Ala Gly Glu Thr Ala Cys Lys Leu Ala Arg Lys Trp Gly Tyr Thr Val 
 145                150                155                160
Lys Gly Ile Gln Lys Tyr Lys Ala Lys Ile Val Phe Ala Ala Gly Asn 
                 165                170                175
Phe Trp Gly Arg Thr Leu Ser Ala Ile Ser Ser Ser Thr Asp Pro Thr 
             180                185                190
Ser Tyr Asp Gly Phe Gly Pro Phe Met Pro Gly Phe Asp Ile Ile Pro 
         195                200                205
Tyr Asn Asp Leu Pro Ala Leu Glu Arg Ala Leu Gln Asp Pro Asn Val 
     210                215                220
Ala Ala Phe Met Val Glu Pro Ile Gln Gly Glu Ala Gly Val Val Val 
 225                230                235                240
Pro Asp Pro Gly Tyr Leu Met Gly Val Arg Glu Leu Cys Thr Arg His 
                 245                250                255
Gln Val Leu Phe Ile Ala Asp Glu Ile Gln Thr Gly Leu Ala Arg Thr 
             260                265                270
Gly Arg Trp Leu Ala Val Asp Tyr Glu Asn Val Arg Pro Asp Ile Val 
         275                280                285
Leu Leu Gly Lys Ala Leu Ser Gly Gly Leu Tyr Pro Val Ser Ala Val 
     290                295                300
Leu Cys Asp Asp Asp Ile Met Leu Thr Ile Lys Pro Gly Glu His Gly 
 305                310                315                320
Ser Thr Tyr Gly Gly Asn Pro Leu Gly Cys Arg Val Ala Ile Ala Ala 
                 325                330                335
Leu Glu Val Leu Glu Glu Glu Asn Leu Ala Glu Asn Ala Asp Lys Leu 
             340                345                350
Gly Ile Ile Leu Arg Asn Glu Leu Met Lys Leu Pro Ser Asp Val Val 
         355                360                365
Thr Ala Val Arg Gly Lys Gly Leu Leu Asn Ala Ile Val Ile Lys Glu 
     370                375                380
Thr Lys Asp Trp Asp Ala Trp Lys Val Cys Leu Arg Leu Arg Asp Asn 
 385                390                395                400
Gly Leu Leu Ala Lys Pro Thr His Gly Asp Ile Ile Arg Phe Ala Pro 
                 405                410                415
Pro Leu Val Ile Lys Glu Asp Glu Leu Arg Glu Ser Ile Glu Ile Ile 
             420                425                430
Asn Lys Thr Ile Leu Ser Phe 
         435



<210> 4109
<211> 2059
<212> DNA
<213> Rattus norvegicus
<308> M93401
<400> 4109

ggcaggaga  gtgatctgt  atctcacct  gcacatgaa  cccattcct  gaactatgc  60
aagggcaga  tctggtgag  catggcggc  gcagtggcg  cagcagcag  agtgcggtc  120
cggatcctg  aggtttctt  taaagtaaa  tccacatgg  atccagcat  ttctttctc  180
tcatcatca  tgccaactg  aaagctctt  attgatggg  aattcgttg  atccaaaag  240
gacaaatgg  ttgacatcc  caacccagc  accaatgag  ttgttggtc  ggttcctca  300
tccaccaaa  ctgaaatgg  ggcagccgt  gccgcctgc  aacgcgctt  ccctgcgtg  360
gcagacaca  ctattttaa  ccggcagca  gtcctgctt  gttatcagc  actcattaa  420
gaaaacctg  aagaaatcg  caggttaat  acattggaa  aagggaaga  tctggctga  480
gctgaagga  atgtgttcc  aggccttca  gtggttgag  atgcctgca  tgtgacgtc  540
ctcatgctg  gagagacca  gccatctat  accaaagac  tggaccttt  ttcctaccg  600
ctgcctctg  gagtgtgtg  aggcatcgc  ccatttaat  ttcctgcca  gatccccct  660
tggatgttt  ccatggcta  ggtctgtgg  aatactttc  taatgaaac  atcagagcg  720
gtacctgga  caaccatgc  tcttgctaa  ttgcttcag  attctggtg  cccggacgg  780
acactgaac  tcatccatg  acaacatga  gctgtaaat  ttatttgcg  tcatccaga  840
atcaaggca  tcagctttg  gggatccaa  caggcggga  agtacatct  cgaaagagg  900
tcaagaaat  gcaagaggg  tcaagccaa  atgggagcc  agaaccatg  ggtagtcat  960
ccagatgcc  ataaggaaa  taccctcaa  cagctggtt  gggcagcat  tggagctgc  1020
gggcagcgc  gcatggctc  ttcaacagc  gtccttgtg  gagaagcta  gaagtggct  1080
ccagaactg  tagagcgtg  caagaatct  cgcgtcaat  caggagatc  gcctggagc  1140
gatcttggt  ccctgatca  cccccaggc  aaagagaga  tctgcaatc  gattgatag  1200
ggagcaaaa  agggggctt  catccttct  gatgggcgg  aaattaaag  taagggcta  1260
gaaaacggt  actttgttg  accaaccat  atctccaat  ttaagccaa  tatgacttg  1320
tacaaagag  agatttttg  tccagttct  gtggtctta  agacagaaa  cctggatga  1380
gccatcaag  ttgttaatg  caacccata  ggaaacggg  ctgctatct  taccaccaa  1440
ggagccata  ctcggaaat  cgctcacat  gtggatgtg  gacaggtgg  cgtgaatgt  1500
cccattcca  tgcctttgc  aatgttttc  ttcaccggc  ctcgatctt  cttcagggg  1560
gacaccaat  tctatggca  acagggcat  cagttttac  ctcagttaa  gactatcac  1620
tctcagtgg  aggaagaag  tgctactct  tcctcacct  cagtggtca  gcctaccat  1680
gggcgttag  acgttcaag  ctccatcca  cctgagtaa  ttcccactg  ccttggcaa  1740
cttcgtctg  catctttgc  caaaacaga  ccatgagga  ggagtatat  gcaatgaaa  1800
tctttctca  aactcgcaa  cccttcaaa  ttataggga  tacaggata  caccaacgc  1860
aggccttca  ttgttctcc  tacttctct  cggtttttg  ggttaactg  tgttaagcg  1920
gaagtgttt  cctagaata  gagcttaga  ctgtcttct  acaattctt  tctgatgac  1980
tggagggac  acgtagggg  ccggtcctt  gcaatcttc  tctgccatc  ttgctcaaa  2040
acagtccat  aggatggag  2059



<210> 4110
<211> 535
<212> PRT
<213> Rattus norvegicus
<308> Q02253
<400> 4110

Met Ala Ala Ala Val Ala Ala Ala Ala Ala Val Arg Ser Arg Ile Leu 
  1               5                  10                  15
Gln Val Ser Ser Lys Val Asn Ser Thr Trp Tyr Pro Ala Ser Ser Phe 
             20                  25                  30
Ser Ser Ser Ser Val Pro Thr Val Lys Leu Phe Ile Asp Gly Lys Phe 
         35                  40                  45
Val Glu Ser Lys Ser Asp Lys Trp Ile Asp Ile His Asn Pro Ala Thr 
     50                  55                  60
Asn Glu Val Val Gly Arg Val Pro Gln Ser Thr Lys Ala Glu Met Glu 
 65                  70                  75                  80
Ala Ala Val Ala Ala Cys Lys Arg Ala Phe Pro Ala Trp Ala Asp Thr 
                 85                  90                  95
Ser Ile Leu Ser Arg Gln Gln Val Leu Leu Arg Tyr Gln Gln Leu Ile 
             100                105                110
Lys Glu Asn Leu Lys Glu Ile Ala Arg Leu Ile Thr Leu Glu Gln Gly 
         115                120                125
Lys Thr Leu Ala Asp Ala Glu Gly Asp Val Phe Arg Gly Leu Gln Val 
     130                135                140
Val Glu His Ala Cys Ser Val Thr Ser Leu Met Leu Gly Glu Thr Met 
 145                150                155                160
Pro Ser Ile Thr Lys Asp Met Asp Leu Tyr Ser Tyr Arg Leu Pro Leu 
                 165                170                175
Gly Val Cys Ala Gly Ile Ala Pro Phe Asn Phe Pro Ala Met Ile Pro 
             180                185                190
Leu Trp Met Phe Pro Met Ala Met Val Cys Gly Asn Thr Phe Leu Met 
         195                200                205
Lys Pro Ser Glu Arg Val Pro Gly Ala Thr Met Leu Leu Ala Lys Leu 
     210                215                220
Leu Gln Asp Ser Gly Ala Pro Asp Gly Thr Leu Asn Ile Ile His Gly 
 225                230                235                240
Gln His Glu Ala Val Asn Phe Ile Cys Asp His Pro Asp Ile Lys Ala 
                 245                250                255
Ile Ser Phe Val Gly Ser Asn Gln Ala Gly Glu Tyr Ile Phe Glu Arg 
             260                265                270
Gly Ser Arg Asn Gly Lys Arg Val Gln Ala Asn Met Gly Ala Lys Asn 
         275                280                285
His Gly Val Val Met Pro Asp Ala Asn Lys Glu Asn Thr Leu Asn Gln 
     290                295                300
Leu Val Gly Ala Ala Phe Gly Ala Ala Gly Gln Arg Cys Met Ala Leu 
 305                310                315                320
Ser Thr Ala Val Leu Val Gly Glu Ala Lys Lys Trp Leu Pro Glu Leu 
                 325                330                335
Val Glu Arg Ala Lys Asn Leu Arg Val Asn Ala Gly Asp Gln Pro Gly 
             340                345                350
Ala Asp Leu Gly Pro Leu Ile Thr Pro Gln Ala Lys Glu Arg Val Cys 
         355                360                365
Asn Leu Ile Asp Ser Gly Ala Lys Glu Gly Ala Ser Ile Leu Leu Asp 
     370                375                380
Gly Arg Lys Ile Lys Val Lys Gly Tyr Glu Asn Gly Asn Phe Val Gly 
 385                390                395                400
Pro Thr Ile Ile Ser Asn Val Lys Pro Ser Met Thr Cys Tyr Lys Glu 
                 405                410                415
Glu Ile Phe Gly Pro Val Leu Val Val Leu Glu Thr Glu Thr Leu Asp 
             420                425                430
Glu Ala Ile Lys Ile Val Asn Asp Asn Pro Tyr Gly Asn Gly Thr Ala 
         435                440                445
Ile Phe Thr Thr Asn Gly Ala Ile Ala Arg Lys Tyr Ala His Met Val 
     450                455                460
Asp Val Gly Gln Val Gly Val Asn Val Pro Ile Pro Val Pro Leu Pro 
 465                470                475                480
Met Phe Ser Phe Thr Gly Ser Arg Ser Ser Phe Arg Gly Asp Thr Asn 
                 485                490                495
Phe Tyr Gly Lys Gln Gly Ile Gln Phe Tyr Thr Gln Leu Lys Thr Ile 
             500                505                510
Thr Ser Gln Trp Lys Glu Glu Asp Ala Thr Leu Ser Ser Pro Ala Val 
         515                520                525
Val Met Pro Thr Met Gly Arg 
     530                535



<210> 4111
<211> 2157
<212> DNA
<213> Homo sapiens
<308> AK026842
<400> 4111

gatcacaaa  ccaaaccct  cagaagaag  tagtaaact  ggagactgc  ctgagttac  60
tgaccaaag  gtttgagag  gaagtttta  aactgcagc  acacgcaat  atagagaac  120
aagcaggtc  ggtagaaat  gacaagctg  agcaccttc  tcagatgaa  gacagggaa  180
tgaatcgtg  gaagaagct  gccaagaac  tactggatg  gagaacaga  gtggaaaga  240
tctttttag  tgctctgca  caagtgaag  aacagatcc  aattagcag  aagcattat  300
agcagatag  acaagctgc  ttcaattta  aaatgagag  agcatgtac  ggaagaaca  360
aatatccca  aatcagaac  tttgatggc  gagagcaca  caccaatag  gtgaatcag  420
atcttctgg  ggccgaaaa  tggacacat  ttgaaggaa  tgtggatat  ggagatttg  480
cctgggagc  gaaggaaaa  gtattgcga  tgctctttg  aaaaatgaa  ggctgtcct  540
ctaggaaat  caaccagag  tctaggcct  cagttccag  ctatgttgt  tctgacagt  600
gggaaacaa  ggaatttgg  gatgaaagt  agcttcaag  taaaatctt  atcacccag  660
aaattgcaa  atcagactc  tctggtgaa  tggtgctac  cactattcc  aaagaacct  720
aggagtctg  cacaggaac  ttctgagaa  cactgatta  gacctcaca  atgctgctg  780
cagtccctt  cttgcagaa  ccttgctcc  gaatatctt  aagaaaatt  cttaaagga  840
aagacaaaa  atttaactc  aaagttacc  gtttgccat  gaaattggt  tctcccctg  900
aggaggatc  agagccggt  aatgagaac  ttggcaaag  cactggaat  gggacattc  960
ctcccacct  aaacagaac  aatccgtgt  atatcctaa  gacaaagga  ctctccatt  1020
agaaacaca  aggcatcag  gaccagttt  aaataccca  cttctaccc  atcctctac  1080
ccatgaact  tcattcctg  ggaagaaat  gggcaatgt  ggaggtcat  ggggcaatc  1140
taaaccaat  actcaccat  atttactgt  tcctcttag  aaatagtaa  tggatataa  1200
aatctctta  aaattctgt  cacgaacct  tccaacatc  accaagtgg  catatttcc  1260
agcagtggc  ccattggtg  tgaagatgg  agttccatt  ccatatggg  tgttattta  1320
aatctggat  gcttcatcc  atgtttctg  ctccagaac  acaagaact  gaccaaaaa  1380
ctcctcttt  taacaggtc  tatttggct  ccaggagtg  tgcatccag  aaagaagtc  1440
gctttttgg  ttctgagta  tttatgctt  tttggtact  tcacttact  cacatcatt  1500
acgtggaca  ctttcatat  actaatctc  tttcatttc  aatcaccta  ttaaaaaaa  1560
agtcctctc  caagtgtat  ccgtcttcc  agttaccaa  catataaac  acttggaat  1620
cctatcaac  ataaccaca  ttcctttaa  ggactgtat  tttagttca  gacccatca  1680
cagctgcct  tttaatacc  gaacgacta  tttcatcca  ttgttatca  aaagttaca  1740
gaaaattta  tttttataa  tccaatcta  agtaaatat  ccaggataa  ttttctctt  1800
acagaaacc  catgctgtt  tctgtaaca  aaataatcc  ttcttattc  ctcctttgc  1860
tcccaaata  gtctgtatg  ttatatttt  atatcaggt  gcagacact  aaaacatcc  1920
tcaccatgc  attaatgtt  gttgctgat  aacggattt  tctgtatgg  tctgtggca  1980
gagatttca  aatttctac  gcacttaca  tcaacactt  atgattcac  attatagta  2040
ggatatatg  atttcaaaa  atgcctcat  acctcaatt  ttaagtcat  ttagctgag  2100
gactttcaa  gttttgata  ataaaaatt  ccaagtcaa  aaaaaaaaa  aaaaaaa  2157



<210> 4112
<211> 535
<212> PRT
<213> Homo sapiens
<308> Q02252
<400> 4112

Met Ala Ala Leu Leu Ala Ala Ala Ala Val Arg Ala Arg Ile Leu Gln 
  1               5                  10                  15
Val Ser Ser Lys Val Lys Ser Ser Pro Thr Trp Tyr Ser Ala Ser Ser 
             20                  25                  30
Phe Ser Ser Ser Val Pro Thr Val Lys Leu Phe Ile Gly Gly Lys Phe 
         35                  40                  45
Val Glu Ser Lys Ser Asp Lys Trp Ile Asp Ile His Asn Pro Ala Thr 
     50                  55                  60
Asn Glu Val Ile Gly Arg Val Pro Gln Ala Thr Lys Ala Glu Met Asp 
 65                  70                  75                  80
Ala Ala Ile Ala Ser Cys Lys Arg Ala Phe Pro Ala Trp Ala Asp Thr 
                 85                  90                  95
Ser Val Leu Ser Arg Gln Gln Val Leu Leu Arg Tyr Gln Gln Leu Ile 
             100                105                110
Lys Glu Asn Leu Lys Glu Ile Ala Lys Leu Ile Thr Leu Glu Gln Gly 
         115                120                125
Lys Thr Leu Ala Asp Ala Glu Gly Asp Val Phe Arg Gly Leu Gln Val 
     130                135                140
Val Glu His Ala Cys Ser Val Thr Ser Leu Met Met Gly Glu Thr Met 
 145                150                155                160
Pro Ser Ile Thr Lys Asp Met Asp Leu Tyr Ser Tyr Arg Leu Pro Leu 
                 165                170                175
Gly Val Cys Ala Gly Ile Ala Pro Phe Asn Phe Pro Ala Met Ile Pro 
             180                185                190
Leu Trp Met Phe Pro Met Ala Met Val Cys Gly Asn Thr Phe Leu Met 
         195                200                205
Lys Pro Ser Glu Arg Val Pro Gly Ala Thr Met Leu Leu Ala Lys Leu 
     210                215                220
Leu Gln Asp Ser Gly Ala Pro Asp Gly Thr Leu Asn Ile Ile His Gly 
 225                230                235                240
Gln His Glu Ala Val Asn Phe Ile Cys Asp His Pro Asp Ile Lys Ala 
                 245                250                255
Ile Ser Phe Val Gly Ser Asn Lys Ala Gly Glu Tyr Ile Phe Glu Arg 
             260                265                270
Gly Ser Arg His Gly Lys Arg Val Gln Ala Asn Met Gly Ala Lys Asn 
         275                280                285
His Gly Val Val Met Pro Asp Ala Asn Lys Glu Asn Thr Leu Asn Gln 
     290                295                300
Leu Val Gly Ala Ala Phe Gly Ala Ala Gly Gln Arg Cys Met Ala Leu 
 305                310                315                320
Ser Thr Ala Val Leu Val Gly Glu Ala Lys Lys Trp Leu Pro Glu Leu 
                 325                330                335
Val Glu His Ala Lys Asn Leu Arg Val Asn Ala Gly Asp Gln Pro Gly 
             340                345                350
Ala Asp Leu Gly Pro Leu Ile Thr Pro Gln Ala Lys Glu Arg Val Cys 
         355                360                365
Asn Leu Ile Asp Ser Gly Thr Lys Glu Gly Ala Ser Ile Leu Leu Asp 
     370                375                380
Gly Arg Lys Ile Lys Val Lys Gly Tyr Glu Asn Gly Asn Phe Val Gly 
 385                390                395                400
Pro Thr Ile Ile Ser Asn Val Lys Pro Asn Met Thr Cys Tyr Lys Glu 
                 405                410                415
Glu Ile Phe Gly Pro Val Leu Val Val Leu Glu Thr Glu Thr Leu Asp 
             420                425                430
Glu Ala Ile Gln Ile Val Asn Asn Asn Pro Tyr Gly Asn Gly Thr Ala 
         435                440                445
Ile Phe Thr Thr Asn Gly Ala Thr Ala Arg Lys Tyr Ala His Leu Val 
     450                455                460
Asp Val Gly Gln Val Gly Val Asn Val Pro Ile Pro Val Pro Leu Pro 
 465                470                475                480
Met Phe Ser Phe Thr Gly Ser Arg Ser Ser Phe Arg Gly Asp Thr Asn 
                 485                490                495
Phe Tyr Gly Lys Gln Gly Ile Gln Phe Tyr Thr Gln Leu Lys Thr Ile 
             500                505                510
Thr Ser Gln Trp Lys Glu Glu Asp Ala Thr Leu Ser Ser Pro Ala Val 
         515                520                525
Val Met Pro Thr Met Gly Arg 
     530                535



<210> 4113
<211> 8287
<212> DNA
<213> Rattus norvegicus
<308> M93661
<400> 4113

agatgccaa  caagtcagt  ctccattgt  tcctggaga  ctgggacag  aagtacaga  60
tcctcagaa  ctgaggaca  ttcatcttc  tcatcttgg  tgaggtcat  aaagtcctc  120
tcctcttct  cctcagccc  gtccttctc  gctccagtg  ctgttcctg  tggggttcc  180
acagactga  catcagcgt  ggctgagtc  tcaggcttc  ctggaggac  gttaagcac  240
gtgccctgg  ccatggagg  cagagtgct  tgtggcaat  ctttgcttg  atccctaat  300
gcatcggga  catcttgag  cacagtagc  tgccgaatt  ggcacgaga  ccaaacttc  360
ggcggcggc  tggctgcgc  gagtgccgg  gcggcgtag  ggcagctcc  ggactcggc  420
agccgcggg  gcagggtag  gcacgcgag  gcggggctc  tggtcggga  ccgctcccc  480
tgcggatct  ctttggctg  ggcagtgaa  atgcccgct  tgcgtcccg  cgcgctgcg  540
gcgctgctg  ggctctggc  gtgcggcgc  ggccccgcg  acgctttgc  gtgtcgagg  600
ggtcaagag  cctgtgtaa  tgaggggac  tgtgttacc  accacaacg  cacaggcta  660
tgccgatgt  cagagggct  cttgggaga  tattgtcaa  atcgagacc  ttgtgagaa  720
aaccgctgt  agaatggtg  tacttgtgt  acgcaggcc  tgttgggaa  agccacctg  780
cgatgtgct  cagggttca  aggggagga  tgccaatac  cgacctctc  cccctgttt  840
gtttcccgc  cctgtcaga  tggaggtac  tgccacatg  tcagctggg  cacctatga  900
tgcacctgt  aagttggct  cacaggaaa  cagtgtcag  ggacagatg  ctgtctgtc  960
catccctgt  aaaatggaa  cacctgtag  tctgtggcc  accagttct  ctgcagatg  1020
cctgcaggc  tcacaggcc  gaagtgtga  gccgacatc  atgaatgtg  cattccagg  1080
cgctgccaa  atggtggca  ctgcctcaa  cttcctggg  cctaccgat  ccaatgccc  1140
cagcggttc  caggccagc  ctgtgacag  ccttacgtg  cctgtgcac  ctcaccctg  1200
gtcaatgga  gcacctgcc  tcagactgg  gacttcact  ctgaatgcc  ttgcctgcc  1260
ggctttgaa  ggagcaact  cgagcggaa  atcgacgac  gccctaacc  caagtgtca  1320
aatggaggg  tgtgtgtgg  tggcgtcaa  acttacaac  gccgctgcc  ccctcagtg  1380
actgggcag  tctgcacag  agacgtgga  gagtgtctg  tgcagccca  tgcttgtca  1440
aatggaggc  cttgcacca  ccgcaacgg  ggctacggc  gcgtgtgcg  gaacggctg  1500
agtggggat  actgcagcg  gaacatcga  gactgtgcc  tcgcttcct  cacgccagg  1560
tccacctgt  ttgaccgtg  ggcctcctt  tcctgcctt  gtccagagg  aaaggcagg  1620
ctcctgtgt  atctggatg  tgcctgtat  agcaaccct  gtcacaagg  ggcgctgtg  1680
gataccaac  ccctgaatg  gcagtacat  tgcacctgc  cacaggcgt  caagggcgc  1740
gactgcaca  aagacgtgg  tgagtgtgc  atggccaac  gtaaccctt  tgagcatgc  1800
ggaaagtgt  tgaatacag  tggcgcctt  cactgcgag  gtctgaagg  ctacgcagg  1860
cctcgctgt  agatggaca  caacgagtg  cactcagac  cctgtcaga  cgacgccac  1920
tgcctggat  agattggag  cttcacctg  ctctgcatg  cgggtttca  aggtgtgca  1980
tgtgaactg  aggtgaatg  atgccagag  aacccgtgt  taaacaatg  gcagtgtgt  2040
gacaaagtc  atcgcttcc  gtgtctgtg  ccccctggt  tcacaggac  agtgtgcca  2100
atcgacatt  acgactgct  cagtactcc  tgcctgaat  gggccaagt  catcgatca  2160
ccgaatggc  atgaatgcc  gtgtgccac  ggattcact  gcacactgt  tgatgagaa  2220
atcgacaac  gtgacccgg  tccttgcca  catggccag  gccaggatg  gattgactc  2280
tacacctgc  tctgcaacc  cgggtacat  ggagccatc  gtagtgacc  gattgatga  2340
tgctacagc  gcccctgcc  gaatgatgg  cgctgcatc  acctggtga  cggctacca  2400
tgcaactgc  aaccgggta  ctcaggcct  aattgtgaa  ttaattttg  tgactgtgc  2460
agcaaccct  gtctgcacg  agcctgtgt  gacggcatc  accgttaca  ttgtgtgtg  2520
tctccggga  tcacagggc  gaggtgcaa  atagacatt  atgagtgtg  ctccaaccc  2580
tgtcgcaag  atgcgacgt  catcaatga  gtgaatggt  tccggtgta  gtgccctga  2640
ggaccacac  atcccagct  ctactcaca  gtgaacgag  gtttgagca  tccctgcat  2700
catggaaac  gtactggag  tctcagtgg  tataagtgc  tctgcgatg  aggctgggt  2760
ggtatcaac  gcgaagtgg  caaaaatga  tgtctttct  acccgtgcc  gaatggagg  2820
acatgtaat  acctggtga  tggctacag  tgtacatgc  agaaggggt  caaaggcta  2880
aactgccag  tgaacatag  tgagtgtgc  tcgaacccg  gtctgaacc  agggacctg  2940
ctcgatgac  tcagtggct  cacctgcca  tgcatgctg  cttacacag  caagaattg  3000
caaacggtg  tggcgccct  ctcccctaa  ccgtgtgag  acgctgcag  ttgtaaaga  3060
gcacccaac  ttgagagct  cacctgcct  tgtgcccct  gctggcaag  tcagcgctg  3120
acagttgac  ttgatgagt  tgtctccaa  ccgtgtatg  acaatggca  ctgccataa  3180
actcagggc  gctacatgt  cgagtgccc  cccggcttc  gtggtatgg  ctgtgagga  3240
gacatcaat  actgccttg  caacccctg  cagaacgga  gctcctgtg  ggacaaagt  3300
aacaccttc  cctgcctgt  ccttcctgg  ttcgtaggg  acaagtgcc  aacagacat  3360
aatgaatgt  tgagcgagc  ctgtaagaa  ggggggacc  gctctgact  cgtcaacag  3420
tacacctgc  cgtgccctg  gggcttcca  ggagtccac  gtgaaaaca  catcgatga  3480
tgcactgag  gctcctgtt  caatggcgg  acgtgtgtt  atgggatca  ctctttctc  3540
tgcttatgc  ctgtgggtt  cactggtcc  ttctgcctc  atgatatca  tgagtgcag  3600
tctaacccg  gcctgaatt  gggaacgtg  gttgatggc  tgggtacct  ccgatgcac  3660
tgtcccttg  gctacactg  gaaaaactg  cagaccctg  tgaacctct  cagcccctc  3720
ccatgtaaa  acaaaggaa  ttgtgctca  gaaaaggca  ggccacgct  cctgtgtcc  3780
cctggatgg  atggcgcat  ctgtgatgt  ctcaatgtg  cctgtaagg  ggcagcctt  3840
cagaaagga  tacctgttg  acacttgtg  cagcactcg  gtatctgta  caatgctgg  3900
aacacgcat  actgccagt  ccccctggg  tacacgggg  gctactgcg  ggaacagct  3960
gacgagtgt  cgtccaatc  atgccagca  ggtgccacc  gcagtgact  catcggagg  4020
tacagatgt  agtgtgttc  agggtatca  ggtgtcaac  gtgagtatg  agtggacga  4080
tgccagaac  agccctgtc  gaacggagg  acctgcatc  acctcgtga  ccatttcaa  4140
tgctcgtgc  caccaggca  ccggggcct  ctttgtgaa  agaacattg  tgactgtgc  4200
ggggccccc  actgcctta  tggtggcca  tgtgtggac  ggattggag  ctacagttg  4260
cgctgtttg  ctggctttg  tggggagcg  tgtgagggg  acatcaatg  atgcctgtc  4320
aatccttgc  gctcagagg  cagcctgga  tgcattcag  tcaaaaata  ctaccagtg  4380
gtctgccgc  gcgccttca  aggccgaca  tgcgaaacc  tcctagatg  gtgtcccca  4440
aagccttgc  tgaatggag  gacttgtgc  gtggctagc  acgtgcctg  tggcttcat  4500
tgtcgttgt  ccccagggt  ctccggggc  agatgccag  gcagctgtg  acaagtgaa  4560
tgcagaaga  gggagcagt  tgtgcacac  gcctcggga  cccactgct  ctgcccgaa  4620
cacaaggac  gcgagtcag  ttgcgctag  aacccctgc  agcacggag  cacctgcta  4680
cctcagcgc  agcctcctt  ctactcttg  cgctgctcc  caccgttct  gggcagcca  4740
tgcgagagc  acacagccc  caccagcac  cctcctgct  cctgtctga  tcagtactg  4800
gccgacaag  ctcgggacg  catctgtga  gaggcctgc  acagtcatg  ctgccagtg  4860
gatggaggt  actgttccc  cactatgga  gacccctgg  ccaactgca  ctcctcact  4920
cgctgctgg  agtacatca  caaccagtg  gatgagctg  gcaacactg  agagtgcct  4980
tttgacaac  ttgaatgcc  gaggaatag  aaaacctgc  agtatgaca  atactgtgc  5040
gaccacttc  aagacaatc  ctgcgataa  ggatgcaac  acgaggagt  tggctggga  5100
gggctggac  gcgctgcgg  ccagcctga  aacctggcg  agggcatcc  ggtcatcgt  5160
gtgctccta  cccctgagc  gctgcttca  gattctcga  gcttcttga  ggccctggg  5220
accctgctc  acaccaact  acgcattaa  caagactct  agggcgccc  catggtgta  5280
ccctactat  gggagaagt  agctgccat  aagaagcag  aggtggcac  caggtctct  5340
cctgatgag  aggaacagg  gataatagg  tctaaggta  ttctggaaa  cgacaaccg  5400
cagtgtgtt  aagactcag  ccagtgctt  aagaacaca  atgctgcag  tgctctcct  5460
gcttctcat  ccatccaag  gaccttgtc  taccctctg  tgtctgttg  cagtgaatc  5520
gaggatcca  ggaacactc  gctcctcta  ctgcttgcg  ttgctgtgg  cattatcct  5580
ttcctcatc  tgctggggg  catcatggc  aagcggaag  gcaagcacg  cttcctctg  5640
ctgcctgaa  gcttcacgc  tcgccgaga  tccagcaat  acaagcgcc  tgaacctgt  5700
gggcaggat  ccgtggggc  gaagaatct  tcagtgcaa  tgtcagagg  aaacctgat  5760
ggctccacg  caagcgagc  ttggggtga  gatgaagga  cccagccaa  gaaagccaa  5820
gctgaggac  acgaggctt  gctgtcgga  gacgaccct  tcgaccggc  cccctggac  5880
cagcagcac  ttgaagctg  agacatccg  cggactcca  ccctggcgc  cacccctcc  5940
caggcagag  aggaggtgg  cgtgctgga  gtgaatgtc  gaggcccag  tgggtgcac  6000
ccactgatg  tggcttctc  ccgaggagg  agctcagac  tgagtgatg  agatgaaga  6060
gctgaggac  cttctgcca  catcatcac  gacttggtc  accaaggtg  cagcctcca  6120
gcacagacg  accgcactg  tgagatggc  ctgcacctt  cagcccgct  ttcgagagc  6180
gatgctgcc  aacgcctcc  ggatgctgg  gcagatgcc  acgcccagg  caacatggg  6240
cgctgtcct  ttcatgctg  agttgcagc  gatgcccaa  gtgtcttcc  gattctgat  6300
cgcaaccga  taacggatc  agacgccag  atgaatgat  gcactaccc  cctgatcct  6360
gctgcccgc  tggctgtgg  aggaatggt  gcagagctg  tcaactgcc  agcagatgt  6420
aacgcagtg  atgaccatg  aaaatctgc  ctccactgg  cagccgccg  caataatgt  6480
gaggcaact  ttttgctgt  gaagaatgg  gccaaccgg  atatgcagg  caacaagga  6540
gagacacct  tgtttcttg  tgcccgaga  ggaagttat  aagcagcca  aatcctgtt  6600
gaccacttt  ccaaccggg  catcacgga  cacatggac  gccttcccc  ggatgtggc  6660
cgggaccgc  tgcaccatg  catagttcg  ctcctggac  agtacaacg  gactcccag  6720
cctccgggg  ctgtcttga  ttctgctct  tcacctgtc  tctgtgggc  caacaggtc  6780
ttcctcagt  tgaagcaca  cccaatggg  aagaaggcc  gacggccca  caccaagag  6840
accatgccc  caagcctgc  taaccttgc  aaggaggcc  aggacgtca  ggggagcag  6900
aggaagaag  gtctcaacg  gaaggtcca  ctctccgag  gctcagtga  tttatcccc  6960
gtcgactcg  tcgagtctc  tcacacata  gtttctgat  ccacgtctt  ccccatgat  7020
acgtcccct  ggatcttac  ggcctcacc  acgcctctt  tggctgctg  cccagctgc  7080
ccagtgcat  ctcagcatg  actgtcttt  tctaacctt  acgaaatgc  gcctttgcg  7140
cctggagcc  gcaccgtgc  cccctcagt  agccagttg  tgtcccacc  ccacatcgt  7200
cccccaggg  gtggcagtg  aggaagctt  ggcaggtta  attcagtcc  tgtcccctc  7260
gactggatg  accgcgtgg  gatgagtga  acccagtac  gtgaaatgt  tggcatggt  7320
ctggctcct  cagagggaa  ccaccctgg  atggcagct  ctcagagca  agctccgga  7380
gggaagccc  tccccacac  gcgtgagcc  ttgcctccc  ttgtaactt  ccagctcat  7440
ccgaaaggc  gccttgctc  ggcagctgg  gctccccag  cacagtccg  ctgcccccc  7500
gctgtggca  gccccttgc  ctctatgta  cagatccca  agatggccc  tttgcccag  7560
gtggctttc  cacctacca  gatgcccca  caggagggg  aggtagctc  gaccattgt  7620
ccaacctat  accctttcc  agcctctgt  ggcaagtac  ccacacccc  ttcccaaca  7680
agttatgcc  cctcaaatg  tgccgagcg  acccccaat  atggtggtc  cctccaggg  7740
gagcacccg  acctgacac  atccccaga  tctcctgac  aatggtcga  ctcttcacc  7800
cactctgcg  ctgactggt  agatgtgac  accagccca  ctcctggag  gggtggagg  7860
ggtcagcgg  gacctggaa  acacatgtc  gagccacca  acagcaaca  gcaggttta  7920
gcatgaaga  tgcctcagt  acacatgga  gtgcccatc  cacgcactc  tgagggccg  7980
gtgaaggtt  tccaagaga  atgaagaga  ctctaacca  cctctggag  caggaggaa  8040
gacgctcct  acttcacac  agcatgagc  gcattattt  catcttcac  gagtatctg  8100
gcagtttag  gaggactca  ctcctactg  cctttgccc  tcctgcaag  tcatggaga  8160
gcaagatga  tgcaagcct  ggggcccct  gctctcttc  tggagagta  gatgaatgc  8220
tgttgtcgc  cggacatcc  tgcagcttg  aacatatca  gccctggag  cttctgcct  8280
catgtgg  8287



<210> 4114
<211> 2471
<212> PRT
<213> Rattus norvegicus
<308> Q9QW30
<400> 4114

Met Pro Ala Leu Arg Pro Ala Ala Leu Arg Ala Leu Leu Trp Leu Trp 
  1               5                  10                  15
Leu Cys Gly Ala Gly Pro Ala His Ala Leu Gln Cys Arg Gly Gly Gln 
             20                  25                  30
Glu Pro Cys Val Asn Glu Gly Thr Cys Val Thr Tyr His Asn Gly Thr 
         35                  40                  45
Gly Tyr Cys Arg Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
     50                  55                  60
Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
 65                  70                  75                  80
Thr Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Pro Gly Phe 
                 85                  90                  95
Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
             100                105                110
Arg Pro Cys Gln Asn Gly Gly Thr Cys His Met Leu Ser Trp Asp Thr 
         115                120                125
Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Gln Cys Gln Trp 
     130                135                140
Thr Asp Val Cys Leu Ser His Pro Cys Glu Asn Gly Ser Thr Cys Ser 
 145                150                155                160
Ser Val Ala Asn Gln Phe Ser Cys Arg Cys Pro Ala Gly Ile Thr Gly 
                 165                170                175
Gln Lys Cys Asp Ala Asp Ile Asn Glu Cys Asp Ile Pro Gly Arg Cys 
             180                185                190
Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Arg Cys Gln 
         195                200                205
Cys Pro Gln Arg Phe Thr Gly Gln His Cys Asp Ser Pro Tyr Val Pro 
     210                215                220
Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
 225                230                235                240
Asp Phe Thr Ser Glu Cys His Cys Leu Pro Gly Phe Glu Gly Ser Asn 
                 245                250                255
Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Lys Cys Gln Asn Gly 
             260                265                270
Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
         275                280                285
Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
     290                295                300
Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Thr Asn Arg Asn Gly 
 305                310                315                320
Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                 325                330                335
Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
             340                345                350
Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Leu Cys Pro Glu Gly Lys 
         355                360                365
Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
     370                375                380
His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
 385                390                395                400
Cys Thr Cys Pro Gln Ala Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                 405                410                415
Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
             420                425                430
Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
         435                440                445
Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
     450                455                460
Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
 465                470                475                480
Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Val Asn 
                 485                490                495
Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
             500                505                510
Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
         515                520                525
Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
     530                535                540
Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
 545                550                555                560
Gly Phe Thr Gly Thr Leu Cys Asp Glu Asn Ile Asp Asn Cys Asp Pro 
                 565                570                575
Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
             580                585                590
Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
         595                600                605
Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
     610                615                620
Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Leu 
 625                630                635                640
Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Leu His 
                 645                650                655
Gly Ala Cys Val Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
             660                665                670
Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
         675                680                685
Asn Pro Cys Arg Lys Asp Ala Thr Cys Ile Asn Asp Val Asn Gly Phe 
     690                695                700
Arg Cys Met Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
 705                710                715                720
Val Asn Glu Cys Leu Ser Ser Pro Cys Ile His Gly Asn Cys Thr Gly 
                 725                730                735
Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
             740                745                750
Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
         755                760                765
Gly Gly Thr Cys Asn Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
     770                775                780
Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
 785                790                795                800
Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Leu Asp Asp Val Ser Gly 
                 805                810                815
Tyr Thr Cys His Cys Met Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
             820                825                830
Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
         835                840                845
Lys Glu Ala Pro Asn Phe Glu Ser Phe Thr Cys Leu Cys Ala Pro Gly 
     850                855                860
Trp Gln Gly Gln Arg Cys Thr Val Asp Val Asp Glu Cys Val Ser Lys 
 865                870                875                880
Pro Cys Met Asn Asn Gly Ile Cys His Asn Thr Gln Gly Ser Tyr Met 
                 885                890                895
Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
             900                905                910
Asn Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Val Asp 
         915                920                925
Lys Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Val Gly Asp 
     930                935                940
Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
 945                950                955                960
Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Thr Cys Pro 
                 965                970                975
Ala Gly Phe His Gly Val His Cys Glu Asn Asn Ile Asp Glu Cys Thr 
             980                985                990
Glu Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser 
         995                1000                1005
Phe Ser Cys Leu Cys Pro Val Gly Phe Thr Gly Pro Phe Cys Leu His 
     1010                1015                1020
Asp Ile Asn Glu Cys Ser Ser Asn Pro Cys Leu Asn Ser Gly Thr Cys 
 1025                1030                1035                1040
Val Asp Gly Leu Gly Thr Tyr Arg Cys Thr Cys Pro Leu Gly Tyr Thr 
                 1045                1050                1055
Gly Lys Asn Cys Gln Thr Leu Val Asn Leu Cys Ser Pro Ser Pro Cys 
             1060                1065                1070
Lys Asn Lys Gly Thr Cys Ala Gln Glu Lys Ala Arg Pro Arg Cys Leu 
         1075                1080                1085
Cys Pro Pro Gly Trp Asp Gly Ala Tyr Cys Asp Val Leu Asn Val Ser 
     1090                1095                1100
Cys Lys Ala Ala Ala Leu Gln Lys Gly Val Pro Val Glu His Leu Cys 
 1105                1110                1115                1120
Gln His Ser Gly Ile Cys Ile Asn Ala Gly Asn Thr His His Cys Gln 
                 1125                1130                1135
Cys Pro Leu Gly Tyr Thr Gly Ser Tyr Cys Glu Glu Gln Leu Asp Glu 
             1140                1145                1150
Cys Ala Ser Asn Pro Cys Gln His Gly Ala Thr Cys Ser Asp Phe Ile 
         1155                1160                1165
Gly Gly Tyr Arg Cys Glu Cys Val Pro Gly Tyr Gln Gly Val Asn Cys 
     1170                1175                1180
Glu Tyr Glu Val Asp Glu Cys Gln Asn Gln Pro Cys Gln Asn Gly Gly 
 1185                1190                1195                1200
Thr Cys Ile Asp Leu Val Asn His Phe Lys Cys Ser Cys Pro Pro Gly 
                 1205                1210                1215
Thr Arg Gly Leu Leu Cys Glu Glu Asn Ile Asp Asp Cys Ala Gly Ala 
             1220                1225                1230
Pro His Cys Leu Asn Gly Gly Gln Cys Val Asp Arg Ile Gly Gly Tyr 
         1235                1240                1245
Ser Cys Arg Cys Leu Pro Gly Phe Ala Gly Glu Arg Cys Glu Gly Asp 
     1250                1255                1260
Ile Asn Glu Cys Leu Ser Asn Pro Cys Ser Ser Glu Gly Ser Leu Asp 
 1265                1270                1275                1280
Cys Ile Gln Leu Lys Asn Asn Tyr Gln Cys Val Cys Arg Ser Ala Phe 
                 1285                1290                1295
Thr Gly Arg His Cys Glu Thr Phe Leu Asp Val Cys Pro Gln Lys Pro 
             1300                1305                1310
Cys Leu Asn Gly Gly Thr Cys Ala Val Ala Ser Asn Val Pro Asp Gly 
         1315                1320                1325
Phe Ile Cys Arg Cys Pro Pro Gly Phe Ser Gly Ala Arg Cys Gln Ser 
     1330                1335                1340
Ser Cys Gly Gln Val Lys Cys Arg Arg Gly Glu Gln Cys Val His Thr 
 1345                1350                1355                1360
Ala Ser Gly Pro His Cys Phe Cys Pro Asn His Lys Asp Cys Glu Ser 
                 1365                1370                1375
Gly Cys Ala Ser Asn Pro Cys Gln His Gly Gly Thr Cys Tyr Pro Gln 
             1380                1385                1390
Arg Gln Pro Pro Tyr Tyr Ser Cys Arg Cys Ser Pro Pro Phe Trp Gly 
         1395                1400                1405
Ser His Cys Glu Ser Tyr Thr Ala Pro Thr Ser Thr Pro Pro Ala Thr 
     1410                1415                1420
Cys Leu Ser Gln Tyr Cys Ala Asp Lys Ala Arg Asp Gly Ile Cys Asp 
 1425                1430                1435                1440
Glu Ala Cys Asn Ser His Ala Cys Gln Trp Asp Gly Gly Asp Cys Ser 
                 1445                1450                1455
Leu Thr Met Glu Asp Pro Trp Ala Asn Cys Thr Ser Ser Leu Arg Cys 
             1460                1465                1470
Trp Glu Tyr Ile Asn Asn Gln Cys Asp Glu Leu Cys Asn Thr Ala Glu 
         1475                1480                1485
Cys Leu Phe Asp Asn Phe Glu Cys Gln Arg Asn Ser Lys Thr Cys Lys 
     1490                1495                1500
Tyr Asp Lys Tyr Cys Ala Asp His Phe Lys Asp Asn His Cys Asp Lys 
 1505                1510                1515                1520
Gly Cys Asn Asn Glu Glu Cys Gly Trp Asp Gly Leu Asp Cys Ala Ala 
                 1525                1530                1535
Asp Gln Pro Glu Asn Leu Ala Glu Gly Ile Leu Val Ile Val Val Leu 
             1540                1545                1550
Leu Pro Pro Glu Gln Leu Leu Gln Asp Ser Arg Ser Phe Leu Arg Ala 
         1555                1560                1565
Leu Gly Thr Leu Leu His Thr Asn Leu Arg Ile Lys Gln Asp Ser Gln 
     1570                1575                1580
Gly Ala Leu Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met 
 1585                1590                1595                1600
Lys Lys Gln Lys Val Ala Arg Arg Ser Leu Pro Asp Glu Gln Glu Gln 
                 1605                1610                1615
Glu Ile Ile Gly Ser Lys Val Phe Leu Glu Ile Asp Asn Arg Gln Cys 
             1620                1625                1630
Val Gln Asp Ser Asp Gln Cys Phe Lys Asn Thr Asp Ala Ala Ala Ala 
         1635                1640                1645
Leu Leu Ala Ser His Ala Ile Gln Gly Thr Leu Ser Tyr Pro Leu Val 
     1650                1655                1660
Ser Val Val Ser Glu Ser Glu Asp Pro Arg Asn Thr Pro Leu Leu Tyr 
 1665                1670                1675                1680
Leu Leu Ala Val Ala Val Val Ile Ile Leu Phe Leu Ile Leu Leu Gly 
                 1685                1690                1695
Val Ile Met Ala Lys Arg Lys Arg Lys His Gly Phe Leu Trp Leu Pro 
             1700                1705                1710
Glu Gly Phe Thr Leu Arg Arg Asp Ser Ser Asn His Lys Arg Arg Glu 
         1715                1720                1725
Pro Val Gly Gln Asp Ala Val Gly Leu Lys Asn Leu Ser Val Gln Val 
     1730                1735                1740
Ser Glu Ala Asn Leu Ile Gly Ser Thr Thr Ser Glu His Trp Gly Asp 
 1745                1750                1755                1760
Asp Glu Gly Pro Gln Pro Lys Lys Ala Lys Ala Glu Asp Asp Glu Ala 
                 1765                1770                1775
Leu Leu Ser Glu Asp Asp Pro Val Asp Arg Arg Pro Trp Thr Gln Gln 
             1780                1785                1790
His Leu Glu Ala Ala Asp Ile Arg Arg Thr Pro Ser Leu Ala Leu Thr 
         1795                1800                1805
Pro Pro Gln Ala Glu Gln Glu Val Asp Val Leu Asp Val Asn Val Arg 
     1810                1815                1820
Gly Pro Asp Gly Cys Thr Pro Leu Met Leu Ala Ser Leu Arg Gly Gly 
 1825                1830                1835                1840
Ser Ser Asp Leu Ser Asp Glu Asp Glu Asp Ala Glu Asp Ser Ser Ala 
                 1845                1850                1855
Asn Ile Ile Thr Asp Leu Val Tyr Gln Gly Ala Ser Leu Gln Ala Gln 
             1860                1865                1870
Thr Asp Arg Thr Gly Glu Met Ala Leu His Leu Ala Ala Arg Tyr Ser 
         1875                1880                1885
Arg Ala Asp Ala Ala Lys Arg Leu Leu Asp Ala Gly Ala Asp Ala Asn 
     1890                1895                1900
Ala Gln Asp Asn Met Gly Arg Cys Pro Leu His Ala Ala Val Ala Ala 
 1905                1910                1915                1920
Asp Ala Gln Gly Val Phe Gln Ile Leu Ile Arg Asn Arg Val Thr Asp 
                 1925                1930                1935
Leu Asp Ala Arg Met Asn Asp Gly Thr Thr Pro Leu Ile Leu Ala Ala 
             1940                1945                1950
Arg Leu Ala Val Glu Gly Met Val Ala Glu Leu Ile Asn Cys Gln Ala 
         1955                1960                1965
Asp Val Asn Ala Val Asp Asp His Gly Lys Ser Ala Leu His Trp Ala 
     1970                1975                1980
Ala Ala Val Asn Asn Val Glu Ala Thr Leu Leu Leu Leu Lys Asn Gly 
 1985                1990                1995                2000
Ala Asn Arg Asp Met Gln Asp Asn Lys Glu Glu Thr Pro Leu Phe Leu 
                 2005                2010                2015
Ala Ala Arg Glu Gly Ser Tyr Glu Ala Ala Lys Ile Leu Leu Asp His 
             2020                2025                2030
Phe Ala Asn Arg Asp Ile Thr Asp His Met Asp Arg Leu Pro Arg Asp 
         2035                2040                2045
Val Ala Arg Asp Arg Met His His Asp Ile Val Arg Leu Leu Asp Glu 
     2050                2055                2060
Tyr Asn Val Thr Pro Ser Pro Pro Gly Thr Val Leu Thr Ser Ala Leu 
 2065                2070                2075                2080
Ser Pro Val Leu Cys Gly Pro Asn Arg Ser Phe Leu Ser Leu Lys His 
                 2085                2090                2095
Thr Pro Met Gly Lys Lys Ala Arg Arg Pro Asn Thr Lys Ser Thr Met 
             2100                2105                2110
Pro Thr Ser Leu Pro Asn Leu Ala Lys Glu Ala Lys Asp Val Lys Gly 
         2115                2120                2125
Ser Arg Arg Lys Lys Cys Leu Asn Glu Lys Val Gln Leu Ser Glu Ser 
     2130                2135                2140
Ser Val Thr Leu Ser Pro Val Asp Ser Leu Glu Ser Pro His Thr Tyr 
 2145                2150                2155                2160
Val Ser Asp Ala Thr Ser Ser Pro Met Ile Thr Ser Pro Gly Ile Leu 
                 2165                2170                2175
Gln Ala Ser Pro Thr Pro Leu Leu Ala Ala Ala Pro Ala Ala Pro Val 
             2180                2185                2190
His Ala Gln His Ala Leu Ser Phe Ser Asn Leu His Glu Met Gln Pro 
         2195                2200                2205
Leu Arg Pro Gly Ala Ser Thr Val Leu Pro Ser Val Ser Gln Leu Leu 
     2210                2215                2220
Ser His His His Ile Val Pro Pro Gly Ser Gly Ser Ala Gly Ser Leu 
 2225                2230                2235                2240
Gly Arg Leu His Ser Val Pro Val Pro Ser Asp Trp Met Asn Arg Val 
                 2245                2250                2255
Glu Met Ser Glu Thr Gln Tyr Ser Glu Met Phe Gly Met Val Leu Ala 
             2260                2265                2270
Pro Ala Glu Gly Thr His Pro Gly Met Ala Ala Pro Gln Ser Arg Ala 
         2275                2280                2285
Pro Glu Gly Lys Pro Ile Pro Thr Gln Arg Glu Pro Leu Pro Pro Ile 
     2290                2295                2300
Val Thr Phe Gln Leu Ile Pro Lys Gly Ser Leu Ala Gln Ala Ala Gly 
 2305                2310                2315                2320
Ala Pro Gln Thr Gln Ser Gly Cys Pro Pro Ala Val Ala Gly Pro Leu 
                 2325                2330                2335
Pro Ser Met Tyr Gln Ile Pro Glu Met Ala Arg Leu Pro Ser Val Ala 
             2340                2345                2350
Phe Pro Pro Thr Met Met Pro Gln Gln Glu Gly Gln Val Ala Gln Thr 
         2355                2360                2365
Ile Val Pro Thr Tyr His Pro Phe Pro Ala Ser Val Gly Lys Tyr Pro 
     2370                2375                2380
Thr Pro Pro Ser Gln His Ser Tyr Ala Ser Ser Asn Ala Ala Glu Arg 
 2385                2390                2395                2400
Thr Pro Asn His Gly Gly His Leu Gln Gly Glu His Pro Tyr Leu Thr 
                 2405                2410                2415
Pro Ser Pro Glu Ser Pro Asp Gln Trp Ser Ser Ser Ser Pro His Ser 
             2420                2425                2430
Ala Ser Asp Trp Ser Asp Val Thr Thr Ser Pro Thr Pro Gly Gly Gly 
         2435                2440                2445
Gly Gly Gly Gln Arg Gly Pro Gly Thr His Met Ser Glu Pro Pro His 
     2450                2455                2460
Ser Asn Met Gln Val Tyr Ala 
 2465                2470



<210> 4115
<211> 543
<212> DNA
<213> Homo sapiens
<308> AA725658
<400> 4115

ttcaatttt  aatcataaa  tttaatttt  gaagtggta  gcctctatt  aacaaaaca  60
acacaaaca  acacacaaa  tcatcagat  cgcagagct  ttgtctctg  cttctccac  120
ggctagggc  tttgccttg  gacatttat  tttgtggct  tggctgtgc  tctcagaat  180
aggactgtt  tttaggtat  tgagcatat  ccaacagtc  gaaacatct  tgtaaacag  240
tttgagaaa  agtgaaaac  ccataccaa  cataaacag  gtgggctta  ctgacgtgc  300
tggctggca  ttgcactgg  agccattga  caggtcaat  cagcgacca  cgttcaggc  360
agggctgct  taacattca  caatctggt  actgcagat  gcgcccatg  acccgggat  420
gcagatgca  gtgtaggaa  caataccat  ctgacactg  ccatggtgg  aaggatcgg  480
gtcacagtt  tcaatgttc  cctcacaca  cacaccagt  aaacctttg  aaagaattt  540
atc  543



<210> 4116
<211> 2471
<212> PRT
<213> Homo sapiens
<308> AAA36377
<400> 4116

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
  1               5                  10                  15
Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
             20                  25                  30
Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
         35                  40                  45
Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
     50                  55                  60
Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
 65                  70                  75                  80
Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                 85                  90                  95
Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
             100                105                110
Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
         115                120                125
Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
     130                135                140
Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
 145                150                155                160
Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                 165                170                175
Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
             180                185                190
Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
         195                200                205
Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
     210                215                220
Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
 225                230                235                240
Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                 245                250                255
Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
             260                265                270
Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
         275                280                285
Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
     290                295                300
Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
 305                310                315                320
Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                 325                330                335
Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
             340                345                350
Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
         355                360                365
Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
     370                375                380
His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
 385                390                395                400
Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                 405                410                415
Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
             420                425                430
Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
         435                440                445
Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
     450                455                460
Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
 465                470                475                480
Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                 485                490                495
Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
             500                505                510
Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
         515                520                525
Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
     530                535                540
Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
 545                550                555                560
Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                 565                570                575
Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
             580                585                590
Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
         595                600                605
Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
     610                615                620
Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
 625                630                635                640
Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                 645                650                655
Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
             660                665                670
Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
         675                680                685
Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
     690                695                700
Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
 705                710                715                720
Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                 725                730                735
Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
             740                745                750
Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
         755                760                765
Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
     770                775                780
Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
 785                790                795                800
Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                 805                810                815
Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
             820                825                830
Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
         835                840                845
Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
     850                855                860
Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
 865                870                875                880
Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                 885                890                895
Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
             900                905                910
Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
         915                920                925
Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
     930                935                940
Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
 945                950                955                960
Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                 965                970                975
Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
             980                985                990
Glu Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser 
         995                1000                1005
Phe Ser Cys Leu Cys Pro Val Gly Phe Thr Gly Ser Phe Cys Leu His 
     1010                1015                1020
Glu Ile Asn Glu Cys Ser Ser His Pro Cys Leu Asn Glu Gly Thr Cys 
 1025                1030                1035                1040
Val Asp Gly Leu Gly Thr Tyr Arg Cys Ser Cys Pro Leu Gly Tyr Thr 
                 1045                1050                1055
Gly Lys Asn Cys Gln Thr Leu Val Asn Leu Cys Ser Arg Ser Pro Cys 
             1060                1065                1070
Lys Asn Lys Gly Thr Cys Val Gln Lys Lys Ala Glu Ser Gln Cys Leu 
         1075                1080                1085
Cys Pro Ser Gly Trp Ala Gly Ala Tyr Cys Asp Val Pro Asn Val Ser 
     1090                1095                1100
Cys Asp Ile Ala Ala Ser Arg Arg Gly Val Leu Val Glu His Leu Cys 
 1105                1110                1115                1120
Gln His Ser Gly Val Cys Ile Asn Ala Gly Asn Thr His Tyr Cys Gln 
                 1125                1130                1135
Cys Pro Leu Gly Tyr Thr Gly Ser Tyr Cys Glu Glu Gln Leu Asp Glu 
             1140                1145                1150
Cys Ala Ser Asn Pro Cys Gln His Gly Ala Thr Cys Ser Asp Phe Ile 
         1155                1160                1165
Gly Gly Tyr Arg Cys Glu Cys Val Pro Gly Tyr Gln Gly Val Asn Cys 
     1170                1175                1180
Glu Tyr Glu Val Asp Glu Cys Gln Asn Gln Pro Cys Gln Asn Gly Gly 
 1185                1190                1195                1200
Thr Cys Ile Asp Leu Val Asn His Phe Lys Cys Ser Cys Pro Pro Gly 
                 1205                1210                1215
Thr Arg Gly Leu Leu Cys Glu Glu Asn Ile Asp Asp Cys Ala Arg Gly 
             1220                1225                1230
Pro His Cys Leu Asn Gly Gly Gln Cys Met Asp Arg Ile Gly Gly Tyr 
         1235                1240                1245
Ser Cys Arg Cys Leu Pro Gly Phe Ala Gly Glu Arg Cys Glu Gly Asp 
     1250                1255                1260
Ile Asn Glu Cys Leu Ser Asn Pro Cys Ser Ser Glu Gly Ser Leu Asp 
 1265                1270                1275                1280
Cys Ile Gln Leu Thr Asn Asp Tyr Leu Cys Val Cys Arg Ser Ala Phe 
                 1285                1290                1295
Thr Gly Arg His Cys Glu Thr Phe Val Asp Val Cys Pro Gln Met Pro 
             1300                1305                1310
Cys Leu Asn Gly Gly Thr Cys Ala Val Ala Ser Asn Met Pro Asp Gly 
         1315                1320                1325
Phe Ile Cys Arg Cys Pro Pro Gly Phe Ser Gly Ala Arg Cys Gln Ser 
     1330                1335                1340
Ser Cys Gly Gln Val Lys Cys Arg Lys Gly Glu Gln Cys Val His Thr 
 1345                1350                1355                1360
Ala Ser Gly Pro Arg Cys Phe Cys Pro Ser Pro Arg Asp Cys Glu Ser 
                 1365                1370                1375
Gly Cys Ala Ser Ser Pro Cys Gln His Gly Gly Ser Cys His Pro Gln 
             1380                1385                1390
Arg Gln Pro Pro Tyr Tyr Ser Cys Gln Cys Ala Pro Pro Phe Ser Gly 
         1395                1400                1405
Ser Arg Cys Glu Leu Tyr Thr Ala Pro Pro Ser Thr Pro Pro Ala Thr 
     1410                1415                1420
Cys Leu Ser Gln Tyr Cys Ala Asp Lys Ala Arg Asp Gly Val Cys Asp 
 1425                1430                1435                1440
Glu Ala Cys Asn Ser His Ala Cys Gln Trp Asp Gly Gly Asp Cys Ser 
                 1445                1450                1455
Leu Thr Met Glu Asn Pro Trp Ala Asn Cys Ser Ser Pro Leu Pro Cys 
             1460                1465                1470
Trp Asp Tyr Ile Asn Asn Gln Cys Asp Glu Leu Cys Asn Thr Val Glu 
         1475                1480                1485
Cys Leu Phe Asp Asn Phe Glu Cys Gln Gly Asn Ser Lys Thr Cys Lys 
     1490                1495                1500
Tyr Asp Lys Tyr Cys Ala Asp His Phe Lys Asp Asn His Cys Asn Gln 
 1505                1510                1515                1520
Gly Cys Asn Ser Glu Glu Cys Gly Trp Asp Gly Leu Asp Cys Ala Ala 
                 1525                1530                1535
Asp Gln Pro Glu Asn Leu Ala Glu Gly Thr Leu Val Ile Val Val Leu 
             1540                1545                1550
Met Pro Pro Glu Gln Leu Leu Gln Asp Ala Arg Ser Phe Leu Arg Ala 
         1555                1560                1565
Leu Gly Thr Leu Leu His Thr Asn Leu Arg Ile Lys Arg Asp Ser Gln 
     1570                1575                1580
Gly Glu Leu Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met 
 1585                1590                1595                1600
Lys Lys Gln Arg Met Thr Arg Arg Ser Leu Pro Gly Glu Gln Glu Gln 
                 1605                1610                1615
Glu Val Ala Gly Ser Lys Val Phe Leu Glu Ile Asp Asn Arg Gln Cys 
             1620                1625                1630
Val Gln Asp Ser Asp His Cys Phe Lys Asn Thr Asp Ala Ala Ala Ala 
         1635                1640                1645
Leu Leu Ala Ser His Ala Ile Gln Gly Thr Leu Ser Tyr Pro Leu Val 
     1650                1655                1660
Ser Val Val Ser Glu Ser Leu Thr Pro Glu Arg Thr Gln Leu Leu Tyr 
 1665                1670                1675                1680
Leu Leu Ala Val Ala Val Val Ile Ile Leu Phe Ile Ile Leu Leu Gly 
                 1685                1690                1695
Val Ile Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro 
             1700                1705                1710
Glu Gly Phe Thr Leu Arg Arg Asp Ala Ser Asn His Lys Arg Arg Glu 
         1715                1720                1725
Pro Val Gly Gln Asp Ala Val Gly Leu Lys Asn Leu Ser Val Gln Val 
     1730                1735                1740
Ser Glu Ala Asn Leu Ile Gly Thr Gly Thr Ser Glu His Trp Val Asp 
 1745                1750                1755                1760
Asp Glu Gly Pro Gln Pro Lys Lys Val Lys Ala Glu Asp Glu Ala Leu 
                 1765                1770                1775
Leu Ser Glu Glu Asp Asp Pro Ile Asp Arg Arg Pro Trp Thr Gln Gln 
             1780                1785                1790
His Leu Glu Ala Ala Asp Ile Arg Arg Thr Pro Ser Leu Ala Leu Thr 
         1795                1800                1805
Pro Pro Gln Ala Glu Gln Glu Val Asp Val Leu Asp Val Asn Val Arg 
     1810                1815                1820
Gly Pro Asp Gly Cys Thr Pro Leu Met Leu Ala Ser Leu Arg Gly Gly 
 1825                1830                1835                1840
Ser Ser Asp Leu Ser Asp Glu Asp Glu Asp Ala Glu Asp Ser Ser Ala 
                 1845                1850                1855
Asn Ile Ile Thr Asp Leu Val Tyr Gln Gly Ala Ser Leu Gln Ala Gln 
             1860                1865                1870
Thr Asp Arg Thr Gly Glu Met Ala Leu His Leu Ala Ala Arg Tyr Ser 
         1875                1880                1885
Arg Ala Asp Ala Ala Lys Arg Leu Leu Asp Ala Gly Ala Asp Ala Asn 
     1890                1895                1900
Ala Gln Asp Asn Met Gly Arg Cys Pro Leu His Ala Ala Val Ala Ala 
 1905                1910                1915                1920
Asp Ala Gln Gly Val Phe Gln Ile Leu Ile Arg Asn Arg Val Thr Asp 
                 1925                1930                1935
Leu Asp Ala Arg Met Asn Asp Gly Thr Thr Pro Leu Ile Leu Ala Ala 
             1940                1945                1950
Arg Leu Ala Val Glu Gly Met Val Ala Glu Leu Ile Asn Cys Gln Ala 
         1955                1960                1965
Asp Val Asn Ala Val Asp Asp His Gly Lys Ser Ala Leu His Trp Ala 
     1970                1975                1980
Ala Ala Val Asn Asn Val Glu Ala Thr Leu Leu Leu Leu Lys Asn Gly 
 1985                1990                1995                2000
Ala Asn Arg Asp Met Gln Asp Asn Lys Glu Glu Thr Pro Leu Phe Leu 
                 2005                2010                2015
Ala Ala Arg Glu Gly Ser Tyr Glu Ala Ala Lys Ile Leu Leu Asp His 
             2020                2025                2030
Phe Ala Asn Arg Asp Ile Thr Asp His Met Asp Arg Leu Pro Arg Asp 
         2035                2040                2045
Val Ala Arg Asp Arg Met His His Asp Ile Val Arg Leu Leu Asp Glu 
     2050                2055                2060
Tyr Asn Val Thr Pro Ser Pro Pro Gly Thr Val Leu Thr Ser Ala Leu 
 2065                2070                2075                2080
Ser Pro Val Ile Cys Gly Pro Asn Arg Ser Phe Leu Ser Leu Lys His 
                 2085                2090                2095
Thr Pro Met Gly Lys Lys Ser Arg Arg Pro Ser Ala Lys Ser Thr Met 
             2100                2105                2110
Pro Thr Ser Leu Pro Asn Leu Ala Lys Glu Ala Lys Asp Ala Lys Gly 
         2115                2120                2125
Ser Arg Arg Lys Lys Ser Leu Ser Glu Lys Val Gln Leu Ser Glu Ser 
     2130                2135                2140
Ser Val Thr Leu Ser Pro Val Asp Ser Leu Glu Ser Pro His Thr Tyr 
 2145                2150                2155                2160
Val Ser Asp Thr Thr Ser Ser Pro Met Ile Thr Ser Pro Gly Ile Leu 
                 2165                2170                2175
Gln Ala Ser Pro Asn Pro Met Leu Ala Thr Ala Ala Pro Pro Ala Pro 
             2180                2185                2190
Val His Ala Gln His Ala Leu Ser Phe Ser Asn Leu His Glu Met Gln 
         2195                2200                2205
Pro Leu Ala His Gly Ala Ser Thr Val Leu Pro Ser Val Ser Gln Leu 
     2210                2215                2220
Leu Ser His His His Ile Val Ser Pro Gly Ser Gly Ser Ala Gly Ser 
 2225                2230                2235                2240
Leu Ser Arg Leu His Pro Val Pro Val Pro Ala Asp Trp Met Asn Arg 
                 2245                2250                2255
Met Glu Val Asn Glu Thr Gln Tyr Asn Glu Met Phe Gly Met Val Leu 
             2260                2265                2270
Ala Pro Ala Glu Gly Thr His Pro Gly Ile Ala Pro Gln Ser Arg Pro 
         2275                2280                2285
Pro Glu Gly Lys His Ile Thr Thr Pro Arg Glu Pro Leu Pro Pro Ile 
     2290                2295                2300
Val Thr Phe Gln Leu Ile Pro Lys Gly Ser Ile Ala Gln Pro Ala Gly 
 2305                2310                2315                2320
Ala Pro Gln Pro Gln Ser Thr Cys Pro Pro Ala Val Ala Gly Pro Leu 
                 2325                2330                2335
Pro Thr Met Tyr Gln Ile Pro Glu Met Ala Arg Leu Pro Ser Val Ala 
             2340                2345                2350
Phe Pro Thr Ala Met Met Pro Gln Gln Asp Gly Gln Val Ala Gln Thr 
         2355                2360                2365
Ile Leu Pro Ala Tyr His Pro Phe Pro Ala Ser Val Gly Lys Tyr Pro 
     2370                2375                2380
Thr Pro Pro Ser Gln His Ser Tyr Ala Ser Ser Asn Ala Ala Glu Arg 
 2385                2390                2395                2400
Thr Pro Ser His Ser Gly His Leu Gln Gly Glu His Pro Tyr Leu Thr 
                 2405                2410                2415
Pro Ser Pro Glu Ser Pro Asp Gln Trp Ser Ser Ser Ser Pro His Ser 
             2420                2425                2430
Ala Ser Asp Trp Ser Asp Val Thr Thr Ser Pro Thr Pro Gly Gly Ala 
         2435                2440                2445
Gly Gly Gly Gln Arg Gly Pro Gly Thr His Met Ser Glu Pro Pro His 
     2450                2455                2460
Asn Asn Met Gln Val Tyr Ala 
 2465                2470



<210> 4117
<211> 2289
<212> DNA
<213> Rattus norvegicus
<308> M93669
<400> 4117

acaatataa  acagaggaa  attttaaga  atgactgaa  cgaaggctt  ccgatttgg  60
gcagttctg  ttcttatcc  cttaatttt  cttgtccct  gaaccgaag  agcttcctt  120
cagcgaaac  agctgcttc  gaaagaacc  gacctcaga  tggagaatg  ccagaagtt  180
cctagtcca  aaatgatca  ggctttgga  tacatagaa  agctcaggc  gcaggccca  240
agagaagaa  gcagcccag  ctacaatcc  taccaaggc  tctctgttc  ccttcaact  300
aaagaaaac  gagaagaaa  tcacttggc  gagagctca  gggatgtcc  gagtgaaga  360
gagtggatg  ggataatac  tgaggcttt  aggcaggct  aaaatgagc  gccatctgc  420
ctcaaggag  acaagccct  tgccttgaa  ctggagaag  acttccctg  ggacacgcc  480
gatgactat  agactcaac  atggcctga  aggaaactc  agcacatgc  gttccctct  540
atgtatgaa  agaattcca  ggaaaaccc  ttcaaacgc  caaacgaaa  agtagaaga  600
cagtacaca  cccaaagtc  tgctaccct  gagtctgtg  tccaagagc  tgggaaact  660
acagggcca  gcaaccaga  gcgtgagag  gttgacgag  aacagaagc  ctacacgga  720
gatgaagat  acgtgtaca  gaccaacaa  attgcctat  aagatgtgg  cgggggaga  780
gactggagt  ctatggagg  gaaaataga  actcaaacc  aggaagagg  gagagacag  840
aaagagaac  cagaaaaaa  cgaacaaat  aatgaagag  tgaaacggt  agggcactt  900
gggctccca  atgaaggta  ccggaaaga  agcaaagac  agctctcag  ggacgcctc  960
aaggtcatc  cctacttga  aaggttagt  aatgctgtg  gcagtggga  gtcccagag  1020
gggcaaaac  gggacaggg  agccaggct  cttgagagg  cccttgatt  tcagtctat  1080
tatcagctg  ttgaaatct  caggaattt  cagataccc  ctgaagact  aattgagat  1140
ctcaaagct  gggagaaac  aaatgggtt  gtggagccc  agcaggatc  ggagcttgc  1200
gttgaccta  atgacatcc  ggaagctga  atagaccgc  cagacatgt  tcaaagtaa  1260
acgctctcc  agggtgggt  tcccaaggc  cctggtcga  gtatgatgg  ggccttgcc  1320
gatggcctc  gtgttgaag  cattttaaa  gttttaggg  tggagaatg  agcaaatca  1380
aagtcccca  atttcccca  ccaatacag  cgagacaag  ctctgctga  gcttcctta  1440
ggtcctggg  aatctagag  caaccagat  cccaaagta  cctggatcc  agacgttga  1500
agcagacaa  ccccctatg  caatctgaa  gataaggac  aagaattgg  agagtactt  1560
gccaggatg  tagttaagt  ccctgagct  atgaatacc  accagctga  gagagtgcc  1620
agcccaggc  cctcagaag  tgacctcca  gaagaagag  agctcgagc  ggccatcaa  1680
gagcatctg  gtcaaggaa  ctcccagga  atggagaaa  tggccaagg  gagcaaaag  1740
atccctgca  gatccctga  gaatgagga  accccaaat  gacagtacc  ggatgaaga  1800
atgctcctg  aagtgctag  gtatctcaa  caagaacag  cagagcagg  aagggaaca  1860
cttgccaaa  gggccatgg  aaacatgta  acagcttta  tgcccaatt  cccttcttt  1920
ccccaagtg  atcccctcc  tttctctta  gtgtgttaa  ctctatcct  ttaacactg  1980
aatatcttt  agtgatgta  aagcagatg  ctccagata  ttttgggga  ctgctttac  2040
tattctgag  tgttatgtt  tgtatggat  tgtataaat  ttatgactc  cagattaaa  2100
atatgtcct  tattcaaga  agatatcta  gatagtgtt  actaatgta  ccaatggtc  2160
tggtattga  aatgctcac  tatgatgaa  agtatccta  aattatctt  gaagttttt  2220
acatttatt  aattatttt  ttactgtct  tagtgtttt  tggagttct  gagcaaaat  2280
aataaagca  2289



<210> 4118
<211> 619
<212> PRT
<213> Rattus norvegicus
<308> P10362
<400> 4118

Met Thr Glu Ser Lys Ala Tyr Arg Phe Gly Ala Val Leu Leu Leu Ile 
  1               5                  10                  15
His Leu Ile Phe Leu Val Pro Gly Thr Glu Ala Ala Ser Phe Gln Arg 
             20                  25                  30
Asn Gln Leu Leu Gln Lys Glu Pro Asp Leu Arg Leu Glu Asn Val Gln 
         35                  40                  45
Lys Phe Pro Ser Pro Glu Met Ile Arg Ala Leu Glu Tyr Ile Glu Lys 
     50                  55                  60
Leu Arg Gln Gln Ala His Arg Glu Glu Ser Ser Pro Asp Tyr Asn Pro 
 65                  70                  75                  80
Tyr Gln Gly Ile Ser Val Pro Leu Gln Leu Lys Glu Asn Gly Glu Glu 
                 85                  90                  95
Ser His Leu Ala Glu Ser Ser Arg Asp Val Leu Ser Glu Asp Glu Trp 
             100                105                110
Met Arg Ile Ile Leu Glu Ala Leu Arg Gln Ala Glu Asn Glu Pro Pro 
         115                120                125
Ser Ala Leu Lys Glu Asn Lys Pro Tyr Ala Leu Asn Leu Glu Lys Asn 
     130                135                140
Phe Pro Val Asp Thr Pro Asp Asp Tyr Glu Thr Gln Gln Trp Pro Glu 
 145                150                155                160
Arg Lys Leu Lys His Met Arg Phe Pro Leu Met Tyr Glu Glu Asn Ser 
                 165                170                175
Arg Glu Asn Pro Phe Lys Arg Thr Asn Glu Ile Val Glu Glu Gln Tyr 
             180                185                190
Thr Pro Gln Ser Leu Ala Thr Leu Glu Ser Val Phe Gln Glu Leu Gly 
         195                200                205
Lys Leu Thr Gly Pro Ser Asn Gln Lys Arg Glu Arg Val Asp Glu Glu 
     210                215                220
Gln Lys Leu Tyr Thr Asp Asp Glu Asp Asp Val Tyr Lys Thr Asn Asn 
 225                230                235                240
Ile Ala Tyr Glu Asp Val Val Gly Gly Glu Asp Trp Ser Pro Met Glu 
                 245                250                255
Glu Lys Ile Glu Thr Gln Thr Gln Glu Glu Val Arg Asp Ser Lys Glu 
             260                265                270
Asn Thr Glu Lys Asn Glu Gln Ile Asn Glu Glu Met Lys Arg Ser Gly 
         275                280                285
His Leu Gly Leu Pro Asp Glu Gly Asn Arg Lys Glu Ser Lys Asp Gln 
     290                295                300
Leu Ser Glu Asp Ala Ser Lys Val Ile Thr Tyr Leu Arg Arg Leu Val 
 305                310                315                320
Asn Ala Val Gly Ser Gly Arg Ser Gln Ser Gly Gln Asn Gly Asp Arg 
                 325                330                335
Ala Ala Arg Leu Leu Glu Arg Pro Leu Asp Ser Gln Ser Ile Tyr Gln 
             340                345                350
Leu Ile Glu Ile Ser Arg Asn Leu Gln Ile Pro Pro Glu Asp Leu Ile 
         355                360                365
Glu Met Leu Lys Ala Gly Glu Lys Pro Asn Gly Leu Val Glu Pro Glu 
     370                375                380
Gln Asp Leu Glu Leu Ala Val Asp Leu Asp Asp Ile Pro Glu Ala Asp 
 385                390                395                400
Ile Asp Arg Pro Asp Met Phe Gln Ser Lys Thr Leu Ser Lys Gly Gly 
                 405                410                415
Tyr Pro Lys Ala Pro Gly Arg Gly Met Met Glu Ala Leu Pro Asp Gly 
             420                425                430
Leu Ser Val Glu Asp Ile Leu Asn Val Leu Gly Met Glu Asn Val Ala 
         435                440                445
Asn Gln Lys Ser Pro Tyr Phe Pro Asn Gln Tyr Ser Arg Asp Lys Ala 
     450                455                460
Leu Leu Arg Leu Pro Tyr Gly Pro Gly Lys Ser Arg Ala Asn Gln Ile 
 465                470                475                480
Pro Lys Val Ala Trp Ile Pro Asp Val Glu Ser Arg Gln Ala Pro Tyr 
                 485                490                495
Asp Asn Leu Asn Asp Lys Asp Gln Glu Leu Gly Glu Tyr Leu Ala Arg 
             500                505                510
Met Leu Val Lys Tyr Pro Glu Leu Met Asn Thr Asn Gln Leu Lys Arg 
         515                520                525
Val Pro Ser Pro Gly Ser Ser Glu Asp Asp Leu Gln Glu Glu Glu Gln 
     530                535                540
Leu Glu Gln Ala Ile Lys Glu His Leu Gly Gln Gly Ser Ser Gln Glu 
 545                550                555                560
Met Glu Lys Leu Ala Lys Val Ser Lys Arg Ile Pro Ala Gly Ser Leu 
                 565                570                575
Lys Asn Glu Asp Thr Pro Asn Arg Gln Tyr Leu Asp Glu Asp Met Leu 
             580                585                590
Leu Lys Val Leu Glu Tyr Leu Asn Gln Glu Gln Ala Glu Gln Gly Arg 
         595                600                605
Glu His Leu Ala Lys Arg Ala Met Glu Asn Met 
     610                615



<210> 4119
<211> 2494
<212> DNA
<213> Homo sapiens
<308> BC022509
<400> 4119

ggcgggcgc  gcggctccc  ataagcaga  gagctgtcc  tgtgctgaa  cggcccgag  60
agctcgccc  gagaacggg  aggaatatg  tgtggagct  ctctgccat  taaacaaaa  120
gaggaaatc  ttcaaacat  gctgaagca  agacccact  gcttggagc  gccctgtct  180
ttatccctt  aattttcct  atctctggg  ctgaagcag  ttcatttca  agaaaccag  240
tgcttcaga  agaaccaga  ctcaggttg  aaaatgtcc  aaagtttcc  agtcctgaa  300
tgatcaggg  tttggagta  atagaaaac  tccgacaac  agctcataa  gaagaaagc  360
gcccagatt  taatcccta  caaggtgtc  ctgtccccc  tcagcaaaa  gaaaatggc  420
atgaaagcc  cttgcccga  agggattca  tgagtgaag  agactggat  agaataata  480
tcgaagctt  gagacaggc  gaaaatgag  ctcagtctg  accaaaaga  aataagccc  540
atgccttga  ttcagaaaa  aactttcca  tggacatga  tgatgatta  gagacacag  600
agtggccag  aagaaagct  aagcacatg  aattccctc  tatgtatga  gagaattcc  660
gggataacc  ctttaaacg  acaaatgaa  tagtggagg  acaatatac  cctcaaagc  720
ttgctacat  ggaatctgt  ttccaagag  tggggaaac  gacaggacc  aacaaccag  780
aacgtgaga  gatggatga  gagcaaaaa  tttatacgg  tgatgaaga  gatatctac  840
aggctaata  cattgccta  gaagatgtg  tcgggggag  agactggaa  ccagtagag  900
agaaaatag  gagtcaaac  caggaagag  tgagagaca  caaagagaa  atagaaaaa  960
atgaacaaa  caatgatga  atgaaacgc  cagggcagc  tggcatcca  gaagaaggt  1020
ttcggaaag  gagtaaaga  caactctca  atgatgtct  caaagtaat  gcctatttg  1080
aaaggttag  aaatgctgc  ggaagtggg  ggttacaga  tgggcaaaa  ggggaaagg  1140
ccaccaggc  ttttgagaa  cctcttgat  ctcagtcta  ttatcagct  attgaaatc  1200
caaggaatt  acagatacc  ccagaagac  taattgaga  gctcaaaac  ggggagaag  1260
cgaatggat  agtggaacc  gagcgggag  ttgaccttc  tgttgacct  gatgacatc  1320
cagaggctg  cttagacca  ccagacctg  tccaaaata  gatgctctc  aagagtggc  1380
accctaaaa  acctggtgg  gctgggact  aggccctac  agacgggct  agtgttgag  1440
atattttaa  tcttttagg  atggagagt  cagcaaatc  gaaaacgtc  tattttccc  1500
atccatata  ccaggagaa  gttctgcca  ggctccctt  tggtgctgg  agatctaga  1560
cgaaccagc  tcccaaagc  gcctggatt  cacatgttg  aaacagaca  atggcatat  1620
aaaacctga  cgacaagga  caagaatta  gtgagtact  ggccaggat  ctagttaaa  1680
accctgaga  cattaattc  aaccaagtg  agcgagttc  tggtcaagg  tcatctgaa  1740
gtgacctgc  ggaagagga  caaattgag  aggccatca  agagcattt  aatcaaggc  1800
gctctcagg  gactgacaa  ctggccccg  tgagcaaaa  gttccctgt  gggcccccg  1860
agaatgatg  taccccaaa  aggcagtac  gggatgaag  tctgttaat  aaagtgctg  1920
aatacctca  ccaagaaaa  gcagaaaag  gaagggagc  tattgctaa  agagcaatg  1980
aaaatatgt  agctgcttt  attaattac  ctactttca  tcctcccac  ccaagcaaa  2040
cccaacatt  ctcttcagt  tgttgactt  tatcctgtt  acactgtaa  atctttaaa  2100
gatgtacag  cagatgaaa  caggtcact  gggagtctg  ttcatttcc  ctgagctgt  2160
atcttgtgt  tggatatgt  taaatgtta  gactccttg  taaaaaatt  attatgtcc  2220
ttattcaag  aagatatct  tgactgtgt  taatagtat  tctaatggc  gtggcattg  2280
tgatgctca  atatgataa  aaagtgtcc  ataattcta  tgaaagttt  taatattta  2340
tgaattatt  tgttactgt  tgtagtgtt  tgtggagta  tggaccaaa  aaataaagc  2400
ttataaata  atagtttta  ttataaggc  ttttctatt  tgtgtttta  tgttgatta  2460
taaatgtta  ttctggaca  aaaaaaaaa  aaaa  2494



<210> 4120
<211> 617
<212> PRT
<213> Homo sapiens
<308> P13521
<400> 4120

Met Ala Glu Ala Lys Thr His Trp Leu Gly Ala Ala Leu Ser Leu Ile 
  1               5                  10                  15
Pro Leu Ile Phe Leu Ile Ser Gly Ala Glu Ala Ala Ser Phe Gln Arg 
             20                  25                  30
Asn Gln Leu Leu Gln Lys Glu Pro Asp Leu Arg Leu Glu Asn Val Gln 
         35                  40                  45
Lys Phe Pro Ser Pro Glu Met Ile Arg Ala Leu Glu Tyr Ile Glu Asn 
     50                  55                  60
Leu Arg Gln Gln Ala His Lys Glu Glu Ser Ser Pro Asp Tyr Asn Pro 
 65                  70                  75                  80
Tyr Gln Gly Val Ser Val Pro Leu Gln Gln Lys Glu Asn Gly Asp Glu 
                 85                  90                  95
Ser His Leu Pro Glu Arg Asp Ser Leu Ser Glu Glu Asp Trp Met Arg 
             100                105                110
Ile Ile Leu Glu Ala Leu Arg Gln Ala Glu Asn Glu Pro Gln Ser Ala 
         115                120                125
Pro Lys Glu Asn Lys Pro Tyr Ala Leu Asn Ser Glu Lys Asn Phe Pro 
     130                135                140
Met Asp Met Ser Asp Asp Tyr Glu Thr Gln Gln Trp Pro Glu Arg Lys 
 145                150                155                160
Leu Lys His Met Gln Phe Pro Pro Met Tyr Glu Glu Asn Ser Arg Asp 
                 165                170                175
Asn Pro Phe Lys Arg Thr Asn Glu Ile Val Glu Glu Gln Tyr Thr Pro 
             180                185                190
Gln Ser Leu Ala Thr Leu Glu Ser Val Phe Gln Glu Leu Gly Lys Leu 
         195                200                205
Thr Gly Pro Asn Asn Gln Lys Arg Glu Arg Met Asp Glu Glu Gln Lys 
     210                215                220
Leu Tyr Thr Asp Asp Glu Asp Asp Ile Tyr Lys Ala Asn Asn Ile Ala 
 225                230                235                240
Tyr Glu Asp Val Val Gly Gly Glu Asp Trp Asn Pro Val Glu Glu Lys 
                 245                250                255
Ile Glu Ser Gln Thr Gln Glu Glu Val Arg Asp Ser Lys Glu Asn Ile 
             260                265                270
Gly Lys Asn Glu Gln Ile Asn Asp Glu Met Lys Arg Ser Gly Gln Leu 
         275                280                285
Gly Ile Gln Glu Glu Asp Leu Arg Lys Glu Ser Lys Asp Gln Leu Ser 
     290                295                300
Asp Asp Val Ser Lys Val Ile Ala Tyr Leu Lys Arg Leu Val Asn Ala 
 305                310                315                320
Ala Gly Ser Gly Arg Leu Gln Asn Gly Gln Asn Gly Glu Arg Ala Thr 
                 325                330                335
Arg Leu Phe Glu Lys Pro Leu Asp Ser Gln Ser Ile Tyr Gln Leu Ile 
             340                345                350
Glu Ile Ser Arg Asn Leu Gln Ile Pro Pro Glu Asp Leu Ile Glu Met 
         355                360                365
Leu Lys Thr Gly Glu Lys Pro Asn Gly Ser Val Glu Pro Glu Arg Glu 
     370                375                380
Leu Asp Leu Pro Val Asp Leu Asp Asp Ile Ser Glu Ala Asp Leu Asp 
 385                390                395                400
His Pro Asp Leu Phe Gln Asn Arg Met Leu Ser Lys Ser Gly Tyr Pro 
                 405                410                415
Lys Thr Pro Gly Arg Ala Gly Thr Glu Ala Leu Pro Asp Gly Leu Ser 
             420                425                430
Val Glu Asp Ile Leu Asn Leu Leu Gly Met Glu Ser Ala Ala Asn Gln 
         435                440                445
Lys Thr Ser Tyr Phe Pro Asn Pro Tyr Asn Gln Glu Lys Val Leu Pro 
     450                455                460
Arg Leu Pro Tyr Gly Ala Gly Arg Ser Arg Ser Asn Gln Leu Pro Lys 
 465                470                475                480
Ala Ala Trp Ile Pro His Val Glu Asn Arg Gln Met Ala Tyr Glu Asn 
                 485                490                495
Leu Asn Asp Lys Asp Gln Glu Leu Gly Glu Tyr Leu Ala Arg Met Leu 
             500                505                510
Val Lys Tyr Pro Glu Ile Ile Asn Ser Asn Gln Val Lys Arg Val Pro 
         515                520                525
Gly Gln Gly Ser Ser Glu Asp Asp Leu Gln Glu Glu Glu Gln Ile Glu 
     530                535                540
Gln Ala Ile Lys Glu His Leu Asn Gln Gly Ser Ser Gln Glu Thr Asp 
 545                550                555                560
Lys Leu Ala Pro Val Ser Lys Arg Phe Pro Val Gly Pro Pro Lys Asn 
                 565                570                575
Asp Asp Thr Pro Asn Arg Gln Tyr Trp Asp Glu Asp Leu Leu Met Lys 
             580                585                590
Val Leu Glu Tyr Leu Asn Gln Glu Lys Ala Glu Lys Gly Arg Glu His 
         595                600                605
Ile Ala Lys Arg Ala Met Glu Asn Met 
     610                615



<210> 4121
<211> 1831
<212> DNA
<213> Rattus norvegicus
<308> M94537
<400> 4121

agccctgct  gcttgggcc  atcccagac  caccggcct  gctagtcca  gccagccgc  60
gacggtggc  gagcatgga  ctgtccccc  gcagtcctc  agagatgct  gagtcggat  120
gcccgtcac  cctggagct  aagtcagcc  ccagcaaga  gatgtggat  aagctacgg  180
ctctgctgc  ctacatggt  aagcagttg  agaatgggg  ggttaacat  gaggagctg  240
agaaaaacc  ggaatacac  gcttccctg  tggaagctg  ctacattga  gagacaagg  300
aaatcttgg  cactgaaga  gagcttcgg  aacttcggt  agatgccgt  ccttcagag  360
tgcgggact  gctggcctc  accttcacc  agcagaccc  agccaaagg  cgcagggca  420
aagagaaac  caagttccg  agcattgtg  acgctgtgc  ggctgggat  ttcgtggag  480
ggatgttcc  gagaacgta  accgctgtg  gtcccacgt  ttctactgc  gtccacaac  540
gtctcaaga  cctggacgt  tggtgcttc  atgtcttct  tttgaaccg  gcagctgat  600
accacgctc  gaggaccat  gtttttgag  tgctgactc  gcatagcct  atcagccgc  660
tcaagattc  cacagtgtt  ctgatgagt  ttctggagg  cttagagac  ggctacggg  720
aatataaga  cccttacca  aaccagatc  atgccgctg  cgtgaccca  actgtccat  780
gcttcctgc  ccgcacagg  atggtgcac  gcctgtcag  gattgaggt  ttggccatc  840
tcttcgcgg  agccatcca  gactatgag  acacaggca  aaccaacag  ttccacatc  900
agaccaagt  agaatgcgc  atcctgtac  atgaccgat  ggtgctgga  aatcaccac  960
tcagctctg  tttccgaat  atgcaggat  atgagatga  catttttat  aatctcacc  1020
aggatgaat  cgtagagct  cgggccctg  tcattgaga  ggtgttagc  acagacatg  1080
cctgccatt  ccagcaagt  aagactatg  agacagccc  gcagcagct  gaaaggatt  1140
acaaatcca  ggccctgtc  cttctgctt  atgctgctg  catcagcca  ccaaccaag  1200
agtggtcag  ccacagccg  tggaccaag  ccctaatgg  agagttctt  cgccagggt  1260
acaaggagg  agagctggg  ttgcccttc  ctccactct  tgaccgcac  tccacattg  1320
tggcccagt  ccagatagg  ttcattgac  tcattgtgg  gcccacctt  tctgtgctg  1380
ctgatgtgg  agaaaagag  gtccagccc  tgacagatg  tgattccaa  tctaaaagt  1440
agcccagct  ccagtggcg  cagccttct  tagatgtgg  cgtaggaga  cccaaccct  1500
atgtggtca  tttccgctc  acctggacc  agtacattc  agagaataa  cagaagtgg  1560
aggaacggg  agcgagtgg  atcaccaac  agatgtcca  tgatgaact  tccccctgt  1620
aggaagaag  cccatcctc  cctgcagaa  atgagcaca  ccagaatgg  aatctggat  1680
agggaactg  gagctggcc  ggtcctcac  gagtccaaa  tcttcgatg  cattagcac  1740
atccatcag  actggttcc  ccatctgct  caagggagt  tgttggttg  gatagagac  1800
gcccacctg  gagccaaat  ttggagcag  t  1831



<210> 4122
<211> 535
<212> PRT
<213> Rattus norvegicus
<308> Q01066
<400> 4122

Met Glu Leu Ser Pro Arg Ser Pro Pro Glu Met Leu Glu Ser Asp Cys 
  1               5                  10                  15
Pro Ser Pro Leu Glu Leu Lys Ser Ala Pro Ser Lys Lys Met Trp Ile 
             20                  25                  30
Lys Leu Arg Ser Leu Leu Arg Tyr Met Val Lys Gln Leu Glu Asn Gly 
         35                  40                  45
Glu Val Asn Ile Glu Glu Leu Lys Lys Asn Leu Glu Tyr Thr Ala Ser 
     50                  55                  60
Leu Leu Glu Ala Val Tyr Ile Asp Glu Thr Arg Gln Ile Leu Asp Thr 
 65                  70                  75                  80
Glu Asp Glu Leu Arg Glu Leu Arg Ser Asp Ala Val Pro Ser Glu Val 
                 85                  90                  95
Arg Asp Trp Leu Ala Ser Thr Phe Thr Gln Gln Thr Arg Ala Lys Gly 
             100                105                110
Arg Arg Ala Glu Glu Lys Pro Lys Phe Arg Ser Ile Val His Ala Val 
         115                120                125
Gln Ala Gly Ile Phe Val Glu Arg Met Phe Arg Arg Thr Tyr Thr Ala 
     130                135                140
Val Gly Pro Thr Tyr Ser Thr Ala Val His Asn Cys Leu Lys Asn Leu 
 145                150                155                160
Asp Val Trp Cys Phe Asp Val Phe Ser Leu Asn Arg Ala Ala Asp Asp 
                 165                170                175
His Ala Leu Arg Thr Ile Val Phe Glu Leu Leu Thr Arg His Ser Leu 
             180                185                190
Ile Ser Arg Phe Lys Ile Pro Thr Val Phe Leu Met Ser Phe Leu Glu 
         195                200                205
Ala Leu Glu Thr Gly Tyr Gly Lys Tyr Lys Asn Pro Tyr His Asn Gln 
     210                215                220
Ile His Ala Ala Asp Val Thr Gln Thr Val His Cys Phe Leu Leu Arg 
 225                230                235                240
Thr Gly Met Val His Cys Leu Ser Glu Ile Glu Val Leu Ala Ile Ile 
                 245                250                255
Phe Ala Ala Ala Ile His Asp Tyr Glu His Thr Gly Thr Thr Asn Ser 
             260                265                270
Phe His Ile Gln Thr Lys Ser Glu Cys Ala Ile Leu Tyr Asn Asp Arg 
         275                280                285
Ser Val Leu Glu Asn His His Ile Ser Ser Val Phe Arg Met Met Gln 
     290                295                300
Asp Asp Glu Met Asn Ile Phe Ile Asn Leu Thr Lys Asp Glu Phe Val 
 305                310                315                320
Glu Leu Arg Ala Leu Val Ile Glu Met Val Leu Ala Thr Asp Met Ser 
                 325                330                335
Cys His Phe Gln Gln Val Lys Thr Met Lys Thr Ala Leu Gln Gln Leu 
             340                345                350
Glu Arg Ile Asp Lys Ser Lys Ala Leu Ser Leu Leu Leu His Ala Ala 
         355                360                365
Asp Ile Ser His Pro Thr Lys Gln Trp Ser Val His Ser Arg Trp Thr 
     370                375                380
Lys Ala Leu Met Glu Glu Phe Phe Arg Gln Gly Asp Lys Glu Ala Glu 
 385                390                395                400
Leu Gly Leu Pro Phe Ser Pro Leu Cys Asp Arg Thr Ser Thr Leu Val 
                 405                410                415
Ala Gln Ser Gln Ile Gly Phe Ile Asp Phe Ile Val Glu Pro Thr Phe 
             420                425                430
Ser Val Leu Thr Asp Val Ala Glu Lys Ser Val Gln Pro Leu Thr Asp 
         435                440                445
Asp Asp Ser Lys Ser Lys Ser Gln Pro Ser Phe Gln Trp Arg Gln Pro 
     450                455                460
Ser Leu Asp Val Asp Val Gly Asp Pro Asn Pro Asp Val Val Ser Phe 
 465                470                475                480
Arg Ser Thr Trp Thr Lys Tyr Ile Gln Glu Asn Lys Gln Lys Trp Lys 
                 485                490                495
Glu Arg Ala Ala Ser Gly Ile Thr Asn Gln Met Ser Ile Asp Glu Leu 
             500                505                510
Ser Pro Cys Glu Glu Glu Ala Pro Ser Ser Pro Ala Glu Asp Glu His 
         515                520                525
Asn Gln Asn Gly Asn Leu Asp 
     530                535



<210> 4123
<211> 2265
<212> DNA
<213> Homo sapiens
<308> U56976
<400> 4123

gctrgtccm  gccagccgc  gaccgtggc  gagcatgga  ctgtccccc  gcagtcctc  60
ggagatgct  gaggagtcg  attgcccgt  acccctgga  ctgaagtca  cccccagca  120
gaagatgtg  attaagctt  ggtctctgc  gcgctacat  gtgaagcag  tggagaatg  180
ggagataaa  attgaggag  tgaagaaaa  tctggagta  acagcttct  tgctggaag  240
cgtctacat  gatgagaca  ggcaaatct  ggacacgga  gacgagctg  aggagctgc  300
gtcagatgc  gtgccttcg  aggtgcggg  ctggctggc  tccaccttc  cccagcagg  360
ccgggccaa  ggccgccga  cagaggaga  gcccaagtt  cgaagcatt  tgcacgctg  420
gcaggctgg  atcttcgtg  aacggatgt  ccggagaac  tacacctct  tgggcccca  480
ttactctac  gcggttctc  actgtctca  gaacctgga  ctctggtgc  ttgatgtct  540
ttccttgaa  caggcagca  atgaccatg  cctgaggac  attgttttt  agttgctga  600
tcggcataa  ctcatcagc  gcttcaaga  tcccactgt  tttttgatg  gtttcctgg  660
tgccttgga  acaggctat  ggaagtaca  gaatcctta  cacaaccag  tccacgcag  720
cgatgttac  cagacagtc  attgcttct  gctccgcac  gggatggtg  actgcctgt  780
ggagattga  ctcctggcc  tcatctttg  tgcagctat  catgattat  agcacacgg  840
cactaccaa  agcttccac  tccagacca  gtcagaatg  gccatcgtg  acaatgatc  900
ttcagtgct  gagaatcac  acatcagct  tgttttccg  ttgatgcag  atgatgaga  960
gaacatttt  atcaacctc  ccaaggatg  gtttgtaga  ctccgagcc  tggtcattg  1020
gatggtgtt  gccacagac  tgtcctgcc  tttccagca  gtgaagacc  tgaagacag  1080
cttgcaaca  ctggagagg  ttgacaagc  caaggccct  tctctactg  tccatgctg  1140
tgacatcag  cacccaacc  agcagtggt  ggtccacag  cgttggacc  aggccctca  1200
ggaggaatt  ttccgtcag  gtgacaagg  ggcagagtt  ggcctgccc  tttctccac  1260
ctgtgaccg  acttccact  tagtggcac  gtctcagat  gggttcatc  acttcattg  1320
ggagcccac  ttctctgtg  tgactgacg  ggcagagaa  agtgttcag  ccctggcgg  1380
tgaggactc  aagtctaaa  accagccca  ctttcagtg  cgccagccc  ctctggatg  1440
ggaagtggg  gaccccaac  ctgatgtgg  cagctttcg  tccacctgg  tcaagcgca  1500
tcaggagaa  aagcagaaa  ggaaggaac  ggcagcaag  ggcatcacc  accagatgt  1560
cattgacga  ctgtccccc  gtgaagaag  ggccccccc  tcccctgcc  aagatgaac  1620
caaccagaa  gggaatctg  attagccct  gggctggcc  aggtcttca  tgagtccaa  1680
gtgtttgat  tcatcagca  catccatca  gactggctc  cccatctgc  ccaagggag  1740
gtggtcgtg  aagaaacaa  ccacctgaa  gccaaatgc  agagatttg  ggttgggga  1800
agggcccct  cccacctga  acccactgg  gtgcacttt  atgttccgg  agcaagact  1860
gggaacttc  ggctcccag  ggtcactgt  cccatccct  agcctctgg  ttctcttca  1920
ggccaggtg  ctgccaggg  gcggggagc  tcctggagg  ttcccaggg  cttggggaa  1980
ggtcagaga  gccagcccc  tgggacctc  cccatcctt  ttgcctcca  gtttctaag  2040
aatacattt  gggggttcc  tcagccccc  accccagat  ttagctggc  ggtctgggt  2100
ccccttttc  tcccctggg  agggctgga  taggataga  agctggggg  tttcagagc  2160
ctatgtgtg  ggaggggag  ggattcctt  agggcatgg  acctttcta  gatctggga  2220
tggggtgga  aggacatcc  cttcacccc  gaattgcgg  aattc  2265



<210> 4124
<211> 536
<212> PRT
<213> Homo sapiens
<308> Q01064
<400> 4124

Met Glu Leu Ser Pro Arg Ser Pro Pro Glu Met Leu Glu Glu Ser Asp 
  1               5                  10                  15
Cys Pro Ser Pro Leu Glu Leu Lys Ser Ala Pro Ser Lys Lys Met Trp 
             20                  25                  30
Ile Lys Leu Arg Ser Leu Leu Arg Tyr Met Val Lys Gln Leu Glu Asn 
         35                  40                  45
Gly Glu Ile Asn Ile Glu Glu Leu Lys Lys Asn Leu Glu Tyr Thr Ala 
     50                  55                  60
Ser Leu Leu Glu Ala Val Tyr Ile Asp Glu Thr Arg Gln Ile Leu Asp 
 65                  70                  75                  80
Thr Glu Asp Glu Leu Gln Glu Leu Arg Ser Asp Ala Val Pro Ser Glu 
                 85                  90                  95
Val Arg Asp Trp Leu Ala Ser Thr Phe Thr Gln Gln Ala Arg Ala Lys 
             100                105                110
Gly Arg Arg Ala Glu Glu Lys Pro Lys Phe Arg Ser Ile Val His Ala 
         115                120                125
Val Gln Ala Gly Ile Phe Val Glu Arg Met Phe Arg Arg Thr Tyr Thr 
     130                135                140
Ser Val Gly Pro Thr Tyr Ser Thr Ala Val Leu Asn Cys Leu Lys Asn 
 145                150                155                160
Leu Asp Leu Trp Cys Phe Asp Val Phe Ser Leu Asn Gln Ala Ala Asp 
                 165                170                175
Asp His Ala Leu Arg Thr Ile Val Phe Glu Leu Leu Thr Arg His Asn 
             180                185                190
Leu Ile Ser Arg Phe Lys Ile Pro Thr Val Phe Leu Met Ser Phe Leu 
         195                200                205
Asp Ala Leu Glu Thr Gly Tyr Gly Lys Tyr Lys Asn Pro Tyr His Asn 
     210                215                220
Gln Ile His Ala Ala Asp Val Thr Gln Thr Val His Cys Phe Leu Leu 
 225                230                235                240
Arg Thr Gly Met Val His Cys Leu Ser Glu Ile Glu Leu Leu Ala Ile 
                 245                250                255
Ile Phe Ala Ala Ala Ile His Asp Tyr Glu His Thr Gly Thr Thr Asn 
             260                265                270
Ser Phe His Ile Gln Thr Lys Ser Glu Cys Ala Ile Val Tyr Asn Asp 
         275                280                285
Arg Ser Val Leu Glu Asn His His Ile Ser Ser Val Phe Arg Leu Met 
     290                295                300
Gln Asp Asp Glu Met Asn Ile Phe Ile Asn Leu Thr Lys Asp Glu Phe 
 305                310                315                320
Val Glu Leu Arg Ala Leu Val Ile Glu Met Val Leu Ala Thr Asp Met 
                 325                330                335
Ser Cys His Phe Gln Gln Val Lys Thr Met Lys Thr Ala Leu Gln Gln 
             340                345                350
Leu Glu Arg Ile Asp Lys Pro Lys Ala Leu Ser Leu Leu Leu His Ala 
         355                360                365
Ala Asp Ile Ser His Pro Thr Lys Gln Trp Leu Val His Ser Arg Trp 
     370                375                380
Thr Lys Ala Leu Met Glu Glu Phe Phe Arg Gln Gly Asp Lys Glu Ala 
 385                390                395                400
Glu Leu Gly Leu Pro Phe Ser Pro Leu Cys Asp Arg Thr Ser Thr Leu 
                 405                410                415
Val Ala Gln Ser Gln Ile Gly Phe Ile Asp Phe Ile Val Glu Pro Thr 
             420                425                430
Phe Ser Val Leu Thr Asp Val Ala Glu Lys Ser Val Gln Pro Leu Ala 
         435                440                445
Asp Glu Asp Ser Lys Ser Lys Asn Gln Pro Ser Phe Gln Trp Arg Gln 
     450                455                460
Pro Ser Leu Asp Val Glu Val Gly Asp Pro Asn Pro Asp Val Val Ser 
 465                470                475                480
Phe Arg Ser Thr Trp Val Lys Arg Ile Gln Glu Asn Lys Gln Lys Trp 
                 485                490                495
Lys Glu Arg Ala Ala Ser Gly Ile Thr Asn Gln Met Ser Ile Asp Glu 
             500                505                510
Leu Ser Pro Cys Glu Glu Glu Ala Pro Pro Ser Pro Ala Glu Asp Glu 
         515                520                525
His Asn Gln Asn Gly Asn Leu Asp 
     530                535



<210> 4125
<211> 707
<212> DNA
<213> Rattus norvegicus
<308> M94555
<400> 4125

ctttggtgt  tgagctcag  aagaggcgc  cgggggacg  tgagggaca  ctttaacac  60
cgcacaaca  agggtacct  gttcccagt  cagagctgc  tggagggca  agatgtcgc  120
agcagctaa  cgccgccca  ggctctccg  aggacaatt  gccgctgca  ctgcatctc  180
tctcctgtc  ctgctgctg  tgctcgcct  ctgtgcgga  gcttgcaga  gtacgccaa  240
atcgcctca  agattacca  cagaacaag  actacaatt  tggaatgag  ttcctgaag  300
ttgtgcgtc  tttctgtct  ttgattccc  gcctcaggc  tctgttgca  tgaggaagc  360
ttgccgtgt  ctgatggag  ttttccaga  gcctcagga  caaactgag  aagataatg  420
taagaggtt  ttatttcat  attcaaaga  acagaagtt  ggaaattca  atgttgtgt  480
gtctgtcgt  catccgttg  tgcagctcg  tcctcaact  catgagaga  gaatgaaga  540
atacaaagt  aatgaatac  agggtcctg  agctccaag  gggggattc  ttttattta  600
gccacgcaa  gggaagagg  caacaagtt  catttaaaa  ggatgccaa  tgatctttt  660
attgaaaac  ctgctatgg  atataaaat  tactcacat  tgttctc  707



<210> 4126
<211> 174
<212> PRT
<213> Rattus norvegicus
<308> P12760
<400> 4126

Met Ser Arg Ala Ala Asn Arg Arg Pro Gly Leu Ser Ala Gly Gln Leu 
  1               5                  10                  15
Ala Ala Ala Thr Ala Ser Pro Leu Leu Ser Leu Leu Leu Leu Leu Ala 
             20                  25                  30
Cys Cys Ala Asp Ala Cys Arg Gly Thr Pro Ile Ser Pro Gln Arg Leu 
         35                  40                  45
Pro Pro Glu Gln Glu Leu Gln Leu Trp Asn Glu Ile Pro Glu Ala Cys 
     50                  55                  60
Ala Ser Phe Leu Ser Val Asp Ser Gln Pro Gln Ala Ser Val Ala Leu 
 65                  70                  75                  80
Arg Lys Leu Cys Arg Val Leu Met Glu Ile Phe Gln Lys Pro Gln Glu 
                 85                  90                  95
Gln Thr Glu Lys Asp Asn Ala Lys Arg Phe Leu Phe His Tyr Ser Lys 
             100                105                110
Thr Gln Lys Leu Gly Asn Ser Asn Val Val Ser Ser Val Val His Pro 
         115                120                125
Leu Leu Gln Leu Val Pro Gln Leu His Glu Arg Arg Met Lys Arg Tyr 
     130                135                140
Lys Val Asn Glu Tyr Gln Gly Pro Val Ala Pro Ser Gly Gly Phe Phe 
 145                150                155                160
Leu Phe Arg Pro Arg Asn Gly Lys Arg Ser Thr Ser Phe Ile 
                 165                170



<210> 4127
<211> 816
<212> DNA
<213> Homo sapiens
<308> BC012908
<400> 4127

ccgaggcac  gccagggca  caggtggag  accagctac  cgtggcgca  cgcagcgtc  60
ctagcaccg  gcctcccgc  gccgccgag  tgctgcgaa  agagagctg  cgccccagg  120
cgcccgccg  acaggtggc  gcggcgtcc  cgctcctgc  gctgctgct  ctgctcgcc  180
ggtgcgcgg  cgcctgccg  ggtgctcca  tattacctc  aggattaca  cctgaacaa  240
agctacagt  gtggaatga  atagatgat  cttgttcgt  ttttctgtc  attgattct  300
agcctcagg  atccaatgc  ctggaggag  tttgcttta  gattatggg  atgctacca  360
agcctcagg  acaagatga  aaagataat  ctaaaaggt  cttatttca  tattcgaag  420
cacagaagt  gggcaagtc  aatgttgtg  cgtcagttg  gcatccgtt  ctgcagctc  480
ttcctcacc  gcatgagag  agaatgaag  gattcagag  ggacgaaga  ttccaaagt  540
cctttgcaa  tcaaagtcg  ggatatttt  tattcaggc  acggaatgg  agaaggtca  600
cagggttca  ttaaaatgg  tgccagcta  ttttccaca  agcaatgct  tggaataca  660
aatgtactg  cattttgtt  tcttctgaa  aaaatcctt  ctaaatgta  tctgttgaa  720
atccctgtg  tgtcaatgt  ctcagttgt  acaatgttg  aaatgttca  tttgttgaa  780
attaaaaaa  ctaaaaata  aaaaaaaaa  aaaaaa  816



<210> 4128
<211> 174
<212> PRT
<213> Homo sapiens
<308> P48645
<400> 4128

Met Leu Arg Thr Glu Ser Cys Arg Pro Arg Ser Pro Ala Gly Gln Val 
  1               5                  10                  15
Ala Ala Ala Ser Pro Leu Leu Leu Leu Leu Leu Leu Leu Ala Trp Cys 
             20                  25                  30
Ala Gly Ala Cys Arg Gly Ala Pro Ile Leu Pro Gln Gly Leu Gln Pro 
         35                  40                  45
Glu Gln Gln Leu Gln Leu Trp Asn Glu Ile Asp Asp Thr Cys Ser Ser 
     50                  55                  60
Phe Leu Ser Ile Asp Ser Gln Pro Gln Ala Ser Asn Ala Leu Glu Glu 
 65                  70                  75                  80
Leu Cys Phe Met Ile Met Gly Met Leu Pro Lys Pro Gln Glu Gln Asp 
                 85                  90                  95
Glu Lys Asp Asn Thr Lys Arg Phe Leu Phe His Tyr Ser Lys Thr Gln 
             100                105                110
Lys Leu Gly Lys Ser Asn Val Val Ser Ser Val Val His Pro Leu Leu 
         115                120                125
Gln Leu Val Pro His Leu His Glu Arg Arg Met Lys Arg Phe Arg Val 
     130                135                140
Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg Gly Tyr Phe 
 145                150                155                160
Leu Phe Arg Pro Arg Asn Gly Arg Arg Ser Ala Gly Phe Ile 
                 165                170



<210> 4129
<211> 1662
<212> DNA
<213> Rattus norvegicus
<308> M95591
<400> 4129

ggccccgct  ctcgccctg  ctaccgccg  catctaaac  caggtggga  tgggagatc  60
cgacaggtg  gccccgcgc  ccgcagcca  aaggatgga  ttcgtgaag  gtctaggcc  120
cccggagga  ttctacaac  tgctgcgat  ccgcatggg  ggccggcgg  atttcatac  180
caagatgga  cggaactcg  tcagcaaca  cttgaagac  tgctataag  atcttgatc  240
gaccagtcg  agcttcgcc  cggttatcc  ggcgctgga  ggggacata  gtcatgcgg  300
gtgtgtgtt  tacctgatc  tccgagcca  ggacacagt  gaggatgac  tggccatca  360
tgtggagaa  aagatccca  tgctgcgaa  ctttcacac  ttcctctat  agccggagt  420
gcggttcac  gagagcaag  agaagcacc  agtagtgct  gaggacttc  ccacgatct  480
cctggagtt  agaaatttg  ctgagaaat  tcaaacagt  atcgctgac  tctgtcaca  540
gatgggatg  gggatggca  aatttctaa  caaggatgt  acctccaaa  aggactggg  600
caagtactg  cactatgtt  ctggactgg  gggaatcgg  ctttctcgc  tattctctg  660
ctcagagtt  gaagatccc  tagttggtg  agacacaga  tgtgccaat  ctatgggtc  720
gtttctgca  aaaacaaat  tcattcgtg  ttatctgga  gaccaacaa  aaggaagac  780
gttttggcc  caagaggta  ggggcaaat  tgttaagaa  ctggaagac  ttgttaagc  840
agagaacgt  gatgtggcc  tgaagtgct  gaatgaact  ataaccaac  ccctacaac  900
catccctga  gtcatcacc  acctgtcaa  gctccggaa  caaagtgtg  ttaacttct  960
tgccattcc  caggtaatg  ccattgcta  gctggctgc  tgttacaat  accatcagg  1020
attcaaggg  gtagtgaag  ttcggaagg  gcaagcagt  accctcatg  tggatgcca  1080
caacatgcc  gctgtcaaa  ctatcatat  ccagtacat  gaagagatt  atcaccggg  1140
ccccaactc  gacccgtca  ctagcaagg  caagcagct  atctccaac  tcaggacgc  1200
gagccttcc  aattgccag  tcatctccc  aagccacta  tcccccatt  acctgtcct  1260
catcatgct  ttggctgcc  tgagctggc  gtacttgag  actctgtcc  aggtcacag  1320
agactatgt  cagagagaa  actgacttt  tttagctgg  agcggaagt  cacgtgaag  1380
gggtttttc  tcttccccc  gctggattt  gacttccct  ggtttttcc  tctactcta  1440
tctttcgga  aactgagtg  gggaccttt  ggaactctg  agaggaaag  acgccttgc  1500
ctcagcagc  tggtgcttc  tggatgtgg  ccctgcctc  tgtagccac  ggcatcatg  1560
tgaccgaag  actggaaag  ccacatgtg  tcctagtga  cctggctag  atgctgatt  1620
aatctattt  atttgaaac  gcctttgaa  acctatcac  gt  1662



<210> 4130
<211> 416
<212> PRT
<213> Rattus norvegicus
<308> Q02769
<400> 4130

Met Glu Phe Val Lys Cys Leu Gly His Pro Glu Glu Phe Tyr Asn Leu 
  1               5                  10                  15
Leu Arg Phe Arg Met Gly Gly Arg Arg Asn Phe Ile Pro Lys Met Asp 
             20                  25                  30
Arg Asn Ser Leu Ser Asn Ser Leu Lys Thr Cys Tyr Lys Tyr Leu Asp 
         35                  40                  45
Gln Thr Ser Arg Ser Phe Ala Ala Val Ile Gln Ala Leu Asp Gly Asp 
     50                  55                  60
Ile Arg His Ala Val Cys Val Phe Tyr Leu Ile Leu Arg Ala Met Asp 
 65                  70                  75                  80
Thr Val Glu Asp Asp Met Ala Ile Ser Val Glu Lys Lys Ile Pro Leu 
                 85                  90                  95
Leu Arg Asn Phe His Thr Phe Leu Tyr Glu Pro Glu Trp Arg Phe Thr 
             100                105                110
Glu Ser Lys Glu Lys His Arg Val Val Leu Glu Asp Phe Pro Thr Ile 
         115                120                125
Ser Leu Glu Phe Arg Asn Leu Ala Glu Lys Tyr Gln Thr Val Ile Ala 
     130                135                140
Asp Ile Cys His Arg Met Gly Cys Gly Met Ala Glu Phe Leu Asn Lys 
 145                150                155                160
Asp Val Thr Ser Lys Gln Asp Trp Asp Lys Tyr Cys His Tyr Val Ala 
                 165                170                175
Gly Leu Val Gly Ile Gly Leu Ser Arg Leu Phe Ser Ala Ser Glu Phe 
             180                185                190
Glu Asp Pro Ile Val Gly Glu Asp Thr Glu Cys Ala Asn Ser Met Gly 
         195                200                205
Leu Phe Leu Gln Lys Thr Asn Ile Ile Arg Asp Tyr Leu Glu Asp Gln 
     210                215                220
Gln Glu Gly Arg Gln Phe Trp Pro Gln Glu Val Trp Gly Lys Tyr Val 
 225                230                235                240
Lys Lys Leu Glu Asp Phe Val Lys Pro Glu Asn Val Asp Val Ala Val 
                 245                250                255
Lys Cys Leu Asn Glu Leu Ile Thr Asn Ala Leu Gln His Ile Pro Asp 
             260                265                270
Val Ile Thr Tyr Leu Ser Arg Leu Arg Asn Gln Ser Val Phe Asn Phe 
         275                280                285
Cys Ala Ile Pro Gln Val Met Ala Ile Ala Thr Leu Ala Ala Cys Tyr 
     290                295                300
Asn Asn His Gln Val Phe Lys Gly Val Val Lys Ile Arg Lys Gly Gln 
 305                310                315                320
Ala Val Thr Leu Met Met Asp Ala Thr Asn Met Pro Ala Val Lys Ala 
                 325                330                335
Ile Ile Tyr Gln Tyr Ile Glu Glu Ile Tyr His Arg Val Pro Asn Ser 
             340                345                350
Asp Pro Ser Ala Ser Lys Ala Lys Gln Leu Ile Ser Asn Ile Arg Thr 
         355                360                365
Gln Ser Leu Pro Asn Cys Gln Leu Ile Ser Arg Ser His Tyr Ser Pro 
     370                375                380
Ile Tyr Leu Ser Phe Ile Met Leu Leu Ala Ala Leu Ser Trp Gln Tyr 
 385                390                395                400
Leu Ser Thr Leu Ser Gln Val Thr Glu Asp Tyr Val Gln Arg Glu His 
                 405                410                415



<210> 4131
<211> 1673
<212> DNA
<213> Homo sapiens
<308> S76822
<400> 4131

gccggtgag  gcctgggga  cgcagaggt  agagtcgcg  ccgggagtc  gccgcctgc  60
ccaggatgg  gttcgtgaa  tgccttggc  accccgaag  gttctacaa  ctggtgcgc  120
tccggatcg  gggcaagcg  aaggtgatg  ccaagatgg  ccaggactc  ctcagcagc  180
gcctgaaaa  ttgctacag  tatctcaat  agaccagtc  cagtttcgc  gctgttatc  240
aggcgctgg  tggggaaat  cgcaacgca  tgtgcatat  ttatctggt  ctccgagct  300
tggacacac  ggaagatga  atgaccatc  gtgtggaaa  gaaggtccc  ctgttacac  360
actttcact  tttccttta  caaccagac  ggcggttca  ggagagcaa  gagaaggat  420
gccaggtgc  ggaggactt  ccaacgatc  cccttgagt  tagaaatct  gctgagaaa  480
accaaacag  gattgccga  atttgccgg  gaatgggca  tgggatggc  gagtttttg  540
ataagcatg  gacctctga  caggagtgg  acaagtact  ccactatgt  gctgggctg  600
tcggaattg  cctttcccg  cttttctca  cctcagagt  tgaagaccc  ttagttggt  660
aagatacag  acgtgccaa  tctatgggc  tgtttctgc  gaaaacaaa  atcatccgt  720
actatctgg  agaccagca  ggaggaaga  agttctggc  tcaagaggt  tggagcagg  780
atgttaaga  gttagggga  tttgctaag  cggagaata  tgacttggc  gtgcagtgc  840
tgaatgaac  tataaccaa  gcactgcac  acatcccag  tgtcatcac  tacctttcg  900
gactcagaa  ccagagtgt  tttaacttc  gtgctattc  acaggtgat  gccattgcc  960
ctttggctg  ctgttataa  aaccagcag  tgttcaaag  ggcagtgaa  attcggaaa  1020
ggcaagcag  gaccctgat  atggatgcc  ccaatatgc  agctgtcaa  gccatcata  1080
atcagtata  ggaagagat  tatcataga  tccccgact  aaacccatc  tctagcaaa  1140
caaggcaga  catctccac  atccggacg  agaatcttc  caactgtca  ctgatttcc  1200
gaagccact  ctcccccat  tacctgtcg  ttgtcatgc  tttggctgc  ctgagctgg  1260
agtacctga  cactctctc  caggtaaca  aagactatg  tcagactgg  gaacactga  1320
cccaaattt  tccatagct  aagtccacc  taaagtgga  ttacttttt  tctctttat  1380
tttttccta  tactttaat  cctaaaaga  cgctgtgtg  ctgggacct  taggaaagt  1440
aaatgcagg  gagaagaac  taaacatga  aggtaaagg  tgcctcatc  cagcaacct  1500
tccttgtgg  tgatgatca  tgtgctgct  gtggctcat  gcagagcat  cagtgccac  1560
gtttaggtg  agtcgctgc  tatgtgact  tcatgagat  ctacttagt  tgatcctgg  1620
tagaatgat  attaaaagt  tttaatttg  agcaaaaaa  aaaaaaaaa  aaa  1673



<210> 4132
<211> 417
<212> PRT
<213> Homo sapiens
<308> P37268
<400> 4132

Met Glu Phe Val Lys Cys Leu Gly His Pro Glu Glu Phe Tyr Asn Leu 
  1               5                  10                  15
Val Arg Phe Arg Ile Gly Gly Lys Arg Lys Val Met Pro Lys Met Asp 
             20                  25                  30
Gln Asp Ser Leu Ser Ser Ser Leu Lys Thr Cys Tyr Lys Tyr Leu Asn 
         35                  40                  45
Gln Thr Ser Arg Ser Phe Ala Ala Val Ile Gln Ala Leu Asp Gly Glu 
     50                  55                  60
Met Arg Asn Ala Val Cys Ile Phe Tyr Leu Val Leu Arg Ala Leu Asp 
 65                  70                  75                  80
Thr Leu Glu Asp Asp Met Thr Ile Ser Val Glu Lys Lys Val Pro Leu 
                 85                  90                  95
Leu His Asn Phe His Ser Phe Leu Tyr Gln Pro Asp Trp Arg Phe Met 
             100                105                110
Glu Ser Lys Glu Lys Asp Arg Gln Val Leu Glu Asp Phe Pro Thr Ile 
         115                120                125
Ser Leu Glu Phe Arg Asn Leu Ala Glu Lys Tyr Gln Thr Val Ile Ala 
     130                135                140
Asp Ile Cys Arg Arg Met Gly Ile Gly Met Ala Glu Phe Leu Asp Lys 
 145                150                155                160
His Val Thr Ser Glu Gln Glu Trp Asp Lys Tyr Cys His Tyr Val Ala 
                 165                170                175
Gly Leu Val Gly Ile Gly Leu Ser Arg Leu Phe Ser Ala Ser Glu Phe 
             180                185                190
Glu Asp Pro Leu Val Gly Glu Asp Thr Glu Arg Ala Asn Ser Met Gly 
         195                200                205
Leu Phe Leu Gln Lys Thr Asn Ile Ile Arg Asp Tyr Leu Glu Asp Gln 
     210                215                220
Gln Gly Gly Arg Glu Phe Trp Pro Gln Glu Val Trp Ser Arg Tyr Val 
 225                230                235                240
Lys Lys Leu Gly Asp Phe Ala Lys Pro Glu Asn Ile Asp Leu Ala Val 
                 245                250                255
Gln Cys Leu Asn Glu Leu Ile Thr Asn Ala Leu His His Ile Pro Asp 
             260                265                270
Val Ile Thr Tyr Leu Ser Arg Leu Arg Asn Gln Ser Val Phe Asn Phe 
         275                280                285
Cys Ala Ile Pro Gln Val Met Ala Ile Ala Thr Leu Ala Ala Cys Tyr 
     290                295                300
Asn Asn Gln Gln Val Phe Lys Gly Ala Val Lys Ile Arg Lys Gly Gln 
 305                310                315                320
Ala Val Thr Leu Met Met Asp Ala Thr Asn Met Pro Ala Val Lys Ala 
                 325                330                335
Ile Ile Tyr Gln Tyr Met Glu Glu Ile Tyr His Arg Ile Pro Asp Ser 
             340                345                350
Asp Pro Ser Ser Ser Lys Thr Arg Gln Ile Ile Ser Thr Ile Arg Thr 
         355                360                365
Gln Asn Leu Pro Asn Cys Gln Leu Ile Ser Arg Ser His Tyr Ser Pro 
     370                375                380
Ile Tyr Leu Ser Phe Val Met Leu Leu Ala Ala Leu Ser Trp Gln Tyr 
 385                390                395                400
Leu Thr Thr Leu Ser Gln Val Thr Glu Asp Tyr Val Gln Thr Gly Glu 
                 405                410                415
His 
             420



<210> 4133
<211> 1662
<212> DNA
<213> Rattus norvegicus
<308> M95591
<400> 4133

ggccccgct  ctcgccctg  ctaccgccg  catctaaac  caggtggga  tgggagatc  60
cgacaggtg  gccccgcgc  ccgcagcca  aaggatgga  ttcgtgaag  gtctaggcc  120
cccggagga  ttctacaac  tgctgcgat  ccgcatggg  ggccggcgg  atttcatac  180
caagatgga  cggaactcg  tcagcaaca  cttgaagac  tgctataag  atcttgatc  240
gaccagtcg  agcttcgcc  cggttatcc  ggcgctgga  ggggacata  gtcatgcgg  300
gtgtgtgtt  tacctgatc  tccgagcca  ggacacagt  gaggatgac  tggccatca  360
tgtggagaa  aagatccca  tgctgcgaa  ctttcacac  ttcctctat  agccggagt  420
gcggttcac  gagagcaag  agaagcacc  agtagtgct  gaggacttc  ccacgatct  480
cctggagtt  agaaatttg  ctgagaaat  tcaaacagt  atcgctgac  tctgtcaca  540
gatgggatg  gggatggca  aatttctaa  caaggatgt  acctccaaa  aggactggg  600
caagtactg  cactatgtt  ctggactgg  gggaatcgg  ctttctcgc  tattctctg  660
ctcagagtt  gaagatccc  tagttggtg  agacacaga  tgtgccaat  ctatgggtc  720
gtttctgca  aaaacaaat  tcattcgtg  ttatctgga  gaccaacaa  aaggaagac  780
gttttggcc  caagaggta  ggggcaaat  tgttaagaa  ctggaagac  ttgttaagc  840
agagaacgt  gatgtggcc  tgaagtgct  gaatgaact  ataaccaac  ccctacaac  900
catccctga  gtcatcacc  acctgtcaa  gctccggaa  caaagtgtg  ttaacttct  960
tgccattcc  caggtaatg  ccattgcta  gctggctgc  tgttacaat  accatcagg  1020
attcaaggg  gtagtgaag  ttcggaagg  gcaagcagt  accctcatg  tggatgcca  1080
caacatgcc  gctgtcaaa  ctatcatat  ccagtacat  gaagagatt  atcaccggg  1140
ccccaactc  gacccgtca  ctagcaagg  caagcagct  atctccaac  tcaggacgc  1200
gagccttcc  aattgccag  tcatctccc  aagccacta  tcccccatt  acctgtcct  1260
catcatgct  ttggctgcc  tgagctggc  gtacttgag  actctgtcc  aggtcacag  1320
agactatgt  cagagagaa  actgacttt  tttagctgg  agcggaagt  cacgtgaag  1380
gggtttttc  tcttccccc  gctggattt  gacttccct  ggtttttcc  tctactcta  1440
tctttcgga  aactgagtg  gggaccttt  ggaactctg  agaggaaag  acgccttgc  1500
ctcagcagc  tggtgcttc  tggatgtgg  ccctgcctc  tgtagccac  ggcatcatg  1560
tgaccgaag  actggaaag  ccacatgtg  tcctagtga  cctggctag  atgctgatt  1620
aatctattt  atttgaaac  gcctttgaa  acctatcac  gt  1662



<210> 4134
<211> 416
<212> PRT
<213> Rattus norvegicus
<308> Q02769
<400> 4134

Met Glu Phe Val Lys Cys Leu Gly His Pro Glu Glu Phe Tyr Asn Leu 
  1               5                  10                  15
Leu Arg Phe Arg Met Gly Gly Arg Arg Asn Phe Ile Pro Lys Met Asp 
             20                  25                  30
Arg Asn Ser Leu Ser Asn Ser Leu Lys Thr Cys Tyr Lys Tyr Leu Asp 
         35                  40                  45
Gln Thr Ser Arg Ser Phe Ala Ala Val Ile Gln Ala Leu Asp Gly Asp 
     50                  55                  60
Ile Arg His Ala Val Cys Val Phe Tyr Leu Ile Leu Arg Ala Met Asp 
 65                  70                  75                  80
Thr Val Glu Asp Asp Met Ala Ile Ser Val Glu Lys Lys Ile Pro Leu 
                 85                  90                  95
Leu Arg Asn Phe His Thr Phe Leu Tyr Glu Pro Glu Trp Arg Phe Thr 
             100                105                110
Glu Ser Lys Glu Lys His Arg Val Val Leu Glu Asp Phe Pro Thr Ile 
         115                120                125
Ser Leu Glu Phe Arg Asn Leu Ala Glu Lys Tyr Gln Thr Val Ile Ala 
     130                135                140
Asp Ile Cys His Arg Met Gly Cys Gly Met Ala Glu Phe Leu Asn Lys 
 145                150                155                160
Asp Val Thr Ser Lys Gln Asp Trp Asp Lys Tyr Cys His Tyr Val Ala 
                 165                170                175
Gly Leu Val Gly Ile Gly Leu Ser Arg Leu Phe Ser Ala Ser Glu Phe 
             180                185                190
Glu Asp Pro Ile Val Gly Glu Asp Thr Glu Cys Ala Asn Ser Met Gly 
         195                200                205
Leu Phe Leu Gln Lys Thr Asn Ile Ile Arg Asp Tyr Leu Glu Asp Gln 
     210                215                220
Gln Glu Gly Arg Gln Phe Trp Pro Gln Glu Val Trp Gly Lys Tyr Val 
 225                230                235                240
Lys Lys Leu Glu Asp Phe Val Lys Pro Glu Asn Val Asp Val Ala Val 
                 245                250                255
Lys Cys Leu Asn Glu Leu Ile Thr Asn Ala Leu Gln His Ile Pro Asp 
             260                265                270
Val Ile Thr Tyr Leu Ser Arg Leu Arg Asn Gln Ser Val Phe Asn Phe 
         275                280                285
Cys Ala Ile Pro Gln Val Met Ala Ile Ala Thr Leu Ala Ala Cys Tyr 
     290                295                300
Asn Asn His Gln Val Phe Lys Gly Val Val Lys Ile Arg Lys Gly Gln 
 305                310                315                320
Ala Val Thr Leu Met Met Asp Ala Thr Asn Met Pro Ala Val Lys Ala 
                 325                330                335
Ile Ile Tyr Gln Tyr Ile Glu Glu Ile Tyr His Arg Val Pro Asn Ser 
             340                345                350
Asp Pro Ser Ala Ser Lys Ala Lys Gln Leu Ile Ser Asn Ile Arg Thr 
         355                360                365
Gln Ser Leu Pro Asn Cys Gln Leu Ile Ser Arg Ser His Tyr Ser Pro 
     370                375                380
Ile Tyr Leu Ser Phe Ile Met Leu Leu Ala Ala Leu Ser Trp Gln Tyr 
 385                390                395                400
Leu Ser Thr Leu Ser Gln Val Thr Glu Asp Tyr Val Gln Arg Glu His 
                 405                410                415



<210> 4135
<211> 1673
<212> DNA
<213> Homo sapiens
<308> S76822
<400> 4135

gccggtgag  gcctgggga  cgcagaggt  agagtcgcg  ccgggagtc  gccgcctgc  60
ccaggatgg  gttcgtgaa  tgccttggc  accccgaag  gttctacaa  ctggtgcgc  120
tccggatcg  gggcaagcg  aaggtgatg  ccaagatgg  ccaggactc  ctcagcagc  180
gcctgaaaa  ttgctacag  tatctcaat  agaccagtc  cagtttcgc  gctgttatc  240
aggcgctgg  tggggaaat  cgcaacgca  tgtgcatat  ttatctggt  ctccgagct  300
tggacacac  ggaagatga  atgaccatc  gtgtggaaa  gaaggtccc  ctgttacac  360
actttcact  tttccttta  caaccagac  ggcggttca  ggagagcaa  gagaaggat  420
gccaggtgc  ggaggactt  ccaacgatc  cccttgagt  tagaaatct  gctgagaaa  480
accaaacag  gattgccga  atttgccgg  gaatgggca  tgggatggc  gagtttttg  540
ataagcatg  gacctctga  caggagtgg  acaagtact  ccactatgt  gctgggctg  600
tcggaattg  cctttcccg  cttttctca  cctcagagt  tgaagaccc  ttagttggt  660
aagatacag  acgtgccaa  tctatgggc  tgtttctgc  gaaaacaaa  atcatccgt  720
actatctgg  agaccagca  ggaggaaga  agttctggc  tcaagaggt  tggagcagg  780
atgttaaga  gttagggga  tttgctaag  cggagaata  tgacttggc  gtgcagtgc  840
tgaatgaac  tataaccaa  gcactgcac  acatcccag  tgtcatcac  tacctttcg  900
gactcagaa  ccagagtgt  tttaacttc  gtgctattc  acaggtgat  gccattgcc  960
ctttggctg  ctgttataa  aaccagcag  tgttcaaag  ggcagtgaa  attcggaaa  1020
ggcaagcag  gaccctgat  atggatgcc  ccaatatgc  agctgtcaa  gccatcata  1080
atcagtata  ggaagagat  tatcataga  tccccgact  aaacccatc  tctagcaaa  1140
caaggcaga  catctccac  atccggacg  agaatcttc  caactgtca  ctgatttcc  1200
gaagccact  ctcccccat  tacctgtcg  ttgtcatgc  tttggctgc  ctgagctgg  1260
agtacctga  cactctctc  caggtaaca  aagactatg  tcagactgg  gaacactga  1320
cccaaattt  tccatagct  aagtccacc  taaagtgga  ttacttttt  tctctttat  1380
tttttccta  tactttaat  cctaaaaga  cgctgtgtg  ctgggacct  taggaaagt  1440
aaatgcagg  gagaagaac  taaacatga  aggtaaagg  tgcctcatc  cagcaacct  1500
tccttgtgg  tgatgatca  tgtgctgct  gtggctcat  gcagagcat  cagtgccac  1560
gtttaggtg  agtcgctgc  tatgtgact  tcatgagat  ctacttagt  tgatcctgg  1620
tagaatgat  attaaaagt  tttaatttg  agcaaaaaa  aaaaaaaaa  aaa  1673



<210> 4136
<211> 417
<212> PRT
<213> Homo sapiens
<308> P37268
<400> 4136

Met Glu Phe Val Lys Cys Leu Gly His Pro Glu Glu Phe Tyr Asn Leu 
  1               5                  10                  15
Val Arg Phe Arg Ile Gly Gly Lys Arg Lys Val Met Pro Lys Met Asp 
             20                  25                  30
Gln Asp Ser Leu Ser Ser Ser Leu Lys Thr Cys Tyr Lys Tyr Leu Asn 
         35                  40                  45
Gln Thr Ser Arg Ser Phe Ala Ala Val Ile Gln Ala Leu Asp Gly Glu 
     50                  55                  60
Met Arg Asn Ala Val Cys Ile Phe Tyr Leu Val Leu Arg Ala Leu Asp 
 65                  70                  75                  80
Thr Leu Glu Asp Asp Met Thr Ile Ser Val Glu Lys Lys Val Pro Leu 
                 85                  90                  95
Leu His Asn Phe His Ser Phe Leu Tyr Gln Pro Asp Trp Arg Phe Met 
             100                105                110
Glu Ser Lys Glu Lys Asp Arg Gln Val Leu Glu Asp Phe Pro Thr Ile 
         115                120                125
Ser Leu Glu Phe Arg Asn Leu Ala Glu Lys Tyr Gln Thr Val Ile Ala 
     130                135                140
Asp Ile Cys Arg Arg Met Gly Ile Gly Met Ala Glu Phe Leu Asp Lys 
 145                150                155                160
His Val Thr Ser Glu Gln Glu Trp Asp Lys Tyr Cys His Tyr Val Ala 
                 165                170                175
Gly Leu Val Gly Ile Gly Leu Ser Arg Leu Phe Ser Ala Ser Glu Phe 
             180                185                190
Glu Asp Pro Leu Val Gly Glu Asp Thr Glu Arg Ala Asn Ser Met Gly 
         195                200                205
Leu Phe Leu Gln Lys Thr Asn Ile Ile Arg Asp Tyr Leu Glu Asp Gln 
     210                215                220
Gln Gly Gly Arg Glu Phe Trp Pro Gln Glu Val Trp Ser Arg Tyr Val 
 225                230                235                240
Lys Lys Leu Gly Asp Phe Ala Lys Pro Glu Asn Ile Asp Leu Ala Val 
                 245                250                255
Gln Cys Leu Asn Glu Leu Ile Thr Asn Ala Leu His His Ile Pro Asp 
             260                265                270
Val Ile Thr Tyr Leu Ser Arg Leu Arg Asn Gln Ser Val Phe Asn Phe 
         275                280                285
Cys Ala Ile Pro Gln Val Met Ala Ile Ala Thr Leu Ala Ala Cys Tyr 
     290                295                300
Asn Asn Gln Gln Val Phe Lys Gly Ala Val Lys Ile Arg Lys Gly Gln 
 305                310                315                320
Ala Val Thr Leu Met Met Asp Ala Thr Asn Met Pro Ala Val Lys Ala 
                 325                330                335
Ile Ile Tyr Gln Tyr Met Glu Glu Ile Tyr His Arg Ile Pro Asp Ser 
             340                345                350
Asp Pro Ser Ser Ser Lys Thr Arg Gln Ile Ile Ser Thr Ile Arg Thr 
         355                360                365
Gln Asn Leu Pro Asn Cys Gln Leu Ile Ser Arg Ser His Tyr Ser Pro 
     370                375                380
Ile Tyr Leu Ser Phe Val Met Leu Leu Ala Ala Leu Ser Trp Gln Tyr 
 385                390                395                400
Leu Thr Thr Leu Ser Gln Val Thr Glu Asp Tyr Val Gln Thr Gly Glu 
                 405                410                415
His 
             420



<210> 4137
<211> 1662
<212> DNA
<213> Rattus norvegicus
<308> M95591
<400> 4137

ggccccgct  ctcgccctg  ctaccgccg  catctaaac  caggtggga  tgggagatc  60
cgacaggtg  gccccgcgc  ccgcagcca  aaggatgga  ttcgtgaag  gtctaggcc  120
cccggagga  ttctacaac  tgctgcgat  ccgcatggg  ggccggcgg  atttcatac  180
caagatgga  cggaactcg  tcagcaaca  cttgaagac  tgctataag  atcttgatc  240
gaccagtcg  agcttcgcc  cggttatcc  ggcgctgga  ggggacata  gtcatgcgg  300
gtgtgtgtt  tacctgatc  tccgagcca  ggacacagt  gaggatgac  tggccatca  360
tgtggagaa  aagatccca  tgctgcgaa  ctttcacac  ttcctctat  agccggagt  420
gcggttcac  gagagcaag  agaagcacc  agtagtgct  gaggacttc  ccacgatct  480
cctggagtt  agaaatttg  ctgagaaat  tcaaacagt  atcgctgac  tctgtcaca  540
gatgggatg  gggatggca  aatttctaa  caaggatgt  acctccaaa  aggactggg  600
caagtactg  cactatgtt  ctggactgg  gggaatcgg  ctttctcgc  tattctctg  660
ctcagagtt  gaagatccc  tagttggtg  agacacaga  tgtgccaat  ctatgggtc  720
gtttctgca  aaaacaaat  tcattcgtg  ttatctgga  gaccaacaa  aaggaagac  780
gttttggcc  caagaggta  ggggcaaat  tgttaagaa  ctggaagac  ttgttaagc  840
agagaacgt  gatgtggcc  tgaagtgct  gaatgaact  ataaccaac  ccctacaac  900
catccctga  gtcatcacc  acctgtcaa  gctccggaa  caaagtgtg  ttaacttct  960
tgccattcc  caggtaatg  ccattgcta  gctggctgc  tgttacaat  accatcagg  1020
attcaaggg  gtagtgaag  ttcggaagg  gcaagcagt  accctcatg  tggatgcca  1080
caacatgcc  gctgtcaaa  ctatcatat  ccagtacat  gaagagatt  atcaccggg  1140
ccccaactc  gacccgtca  ctagcaagg  caagcagct  atctccaac  tcaggacgc  1200
gagccttcc  aattgccag  tcatctccc  aagccacta  tcccccatt  acctgtcct  1260
catcatgct  ttggctgcc  tgagctggc  gtacttgag  actctgtcc  aggtcacag  1320
agactatgt  cagagagaa  actgacttt  tttagctgg  agcggaagt  cacgtgaag  1380
gggtttttc  tcttccccc  gctggattt  gacttccct  ggtttttcc  tctactcta  1440
tctttcgga  aactgagtg  gggaccttt  ggaactctg  agaggaaag  acgccttgc  1500
ctcagcagc  tggtgcttc  tggatgtgg  ccctgcctc  tgtagccac  ggcatcatg  1560
tgaccgaag  actggaaag  ccacatgtg  tcctagtga  cctggctag  atgctgatt  1620
aatctattt  atttgaaac  gcctttgaa  acctatcac  gt  1662



<210> 4138
<211> 416
<212> PRT
<213> Rattus norvegicus
<308> Q02769
<400> 4138

Met Glu Phe Val Lys Cys Leu Gly His Pro Glu Glu Phe Tyr Asn Leu 
  1               5                  10                  15
Leu Arg Phe Arg Met Gly Gly Arg Arg Asn Phe Ile Pro Lys Met Asp 
             20                  25                  30
Arg Asn Ser Leu Ser Asn Ser Leu Lys Thr Cys Tyr Lys Tyr Leu Asp 
         35                  40                  45
Gln Thr Ser Arg Ser Phe Ala Ala Val Ile Gln Ala Leu Asp Gly Asp 
     50                  55                  60
Ile Arg His Ala Val Cys Val Phe Tyr Leu Ile Leu Arg Ala Met Asp 
 65                  70                  75                  80
Thr Val Glu Asp Asp Met Ala Ile Ser Val Glu Lys Lys Ile Pro Leu 
                 85                  90                  95
Leu Arg Asn Phe His Thr Phe Leu Tyr Glu Pro Glu Trp Arg Phe Thr 
             100                105                110
Glu Ser Lys Glu Lys His Arg Val Val Leu Glu Asp Phe Pro Thr Ile 
         115                120                125
Ser Leu Glu Phe Arg Asn Leu Ala Glu Lys Tyr Gln Thr Val Ile Ala 
     130                135                140
Asp Ile Cys His Arg Met Gly Cys Gly Met Ala Glu Phe Leu Asn Lys 
 145                150                155                160
Asp Val Thr Ser Lys Gln Asp Trp Asp Lys Tyr Cys His Tyr Val Ala 
                 165                170                175
Gly Leu Val Gly Ile Gly Leu Ser Arg Leu Phe Ser Ala Ser Glu Phe 
             180                185                190
Glu Asp Pro Ile Val Gly Glu Asp Thr Glu Cys Ala Asn Ser Met Gly 
         195                200                205
Leu Phe Leu Gln Lys Thr Asn Ile Ile Arg Asp Tyr Leu Glu Asp Gln 
     210                215                220
Gln Glu Gly Arg Gln Phe Trp Pro Gln Glu Val Trp Gly Lys Tyr Val 
 225                230                235                240
Lys Lys Leu Glu Asp Phe Val Lys Pro Glu Asn Val Asp Val Ala Val 
                 245                250                255
Lys Cys Leu Asn Glu Leu Ile Thr Asn Ala Leu Gln His Ile Pro Asp 
             260                265                270
Val Ile Thr Tyr Leu Ser Arg Leu Arg Asn Gln Ser Val Phe Asn Phe 
         275                280                285
Cys Ala Ile Pro Gln Val Met Ala Ile Ala Thr Leu Ala Ala Cys Tyr 
     290                295                300
Asn Asn His Gln Val Phe Lys Gly Val Val Lys Ile Arg Lys Gly Gln 
 305                310                315                320
Ala Val Thr Leu Met Met Asp Ala Thr Asn Met Pro Ala Val Lys Ala 
                 325                330                335
Ile Ile Tyr Gln Tyr Ile Glu Glu Ile Tyr His Arg Val Pro Asn Ser 
             340                345                350
Asp Pro Ser Ala Ser Lys Ala Lys Gln Leu Ile Ser Asn Ile Arg Thr 
         355                360                365
Gln Ser Leu Pro Asn Cys Gln Leu Ile Ser Arg Ser His Tyr Ser Pro 
     370                375                380
Ile Tyr Leu Ser Phe Ile Met Leu Leu Ala Ala Leu Ser Trp Gln Tyr 
 385                390                395                400
Leu Ser Thr Leu Ser Gln Val Thr Glu Asp Tyr Val Gln Arg Glu His 
                 405                410                415



<210> 4139
<211> 1673
<212> DNA
<213> Homo sapiens
<308> S76822
<400> 4139

gccggtgag  gcctgggga  cgcagaggt  agagtcgcg  ccgggagtc  gccgcctgc  60
ccaggatgg  gttcgtgaa  tgccttggc  accccgaag  gttctacaa  ctggtgcgc  120
tccggatcg  gggcaagcg  aaggtgatg  ccaagatgg  ccaggactc  ctcagcagc  180
gcctgaaaa  ttgctacag  tatctcaat  agaccagtc  cagtttcgc  gctgttatc  240
aggcgctgg  tggggaaat  cgcaacgca  tgtgcatat  ttatctggt  ctccgagct  300
tggacacac  ggaagatga  atgaccatc  gtgtggaaa  gaaggtccc  ctgttacac  360
actttcact  tttccttta  caaccagac  ggcggttca  ggagagcaa  gagaaggat  420
gccaggtgc  ggaggactt  ccaacgatc  cccttgagt  tagaaatct  gctgagaaa  480
accaaacag  gattgccga  atttgccgg  gaatgggca  tgggatggc  gagtttttg  540
ataagcatg  gacctctga  caggagtgg  acaagtact  ccactatgt  gctgggctg  600
tcggaattg  cctttcccg  cttttctca  cctcagagt  tgaagaccc  ttagttggt  660
aagatacag  acgtgccaa  tctatgggc  tgtttctgc  gaaaacaaa  atcatccgt  720
actatctgg  agaccagca  ggaggaaga  agttctggc  tcaagaggt  tggagcagg  780
atgttaaga  gttagggga  tttgctaag  cggagaata  tgacttggc  gtgcagtgc  840
tgaatgaac  tataaccaa  gcactgcac  acatcccag  tgtcatcac  tacctttcg  900
gactcagaa  ccagagtgt  tttaacttc  gtgctattc  acaggtgat  gccattgcc  960
ctttggctg  ctgttataa  aaccagcag  tgttcaaag  ggcagtgaa  attcggaaa  1020
ggcaagcag  gaccctgat  atggatgcc  ccaatatgc  agctgtcaa  gccatcata  1080
atcagtata  ggaagagat  tatcataga  tccccgact  aaacccatc  tctagcaaa  1140
caaggcaga  catctccac  atccggacg  agaatcttc  caactgtca  ctgatttcc  1200
gaagccact  ctcccccat  tacctgtcg  ttgtcatgc  tttggctgc  ctgagctgg  1260
agtacctga  cactctctc  caggtaaca  aagactatg  tcagactgg  gaacactga  1320
cccaaattt  tccatagct  aagtccacc  taaagtgga  ttacttttt  tctctttat  1380
tttttccta  tactttaat  cctaaaaga  cgctgtgtg  ctgggacct  taggaaagt  1440
aaatgcagg  gagaagaac  taaacatga  aggtaaagg  tgcctcatc  cagcaacct  1500
tccttgtgg  tgatgatca  tgtgctgct  gtggctcat  gcagagcat  cagtgccac  1560
gtttaggtg  agtcgctgc  tatgtgact  tcatgagat  ctacttagt  tgatcctgg  1620
tagaatgat  attaaaagt  tttaatttg  agcaaaaaa  aaaaaaaaa  aaa  1673



<210> 4140
<211> 417
<212> PRT
<213> Homo sapiens
<308> P37268
<400> 4140

Met Glu Phe Val Lys Cys Leu Gly His Pro Glu Glu Phe Tyr Asn Leu 
  1               5                  10                  15
Val Arg Phe Arg Ile Gly Gly Lys Arg Lys Val Met Pro Lys Met Asp 
             20                  25                  30
Gln Asp Ser Leu Ser Ser Ser Leu Lys Thr Cys Tyr Lys Tyr Leu Asn 
         35                  40                  45
Gln Thr Ser Arg Ser Phe Ala Ala Val Ile Gln Ala Leu Asp Gly Glu 
     50                  55                  60
Met Arg Asn Ala Val Cys Ile Phe Tyr Leu Val Leu Arg Ala Leu Asp 
 65                  70                  75                  80
Thr Leu Glu Asp Asp Met Thr Ile Ser Val Glu Lys Lys Val Pro Leu 
                 85                  90                  95
Leu His Asn Phe His Ser Phe Leu Tyr Gln Pro Asp Trp Arg Phe Met 
             100                105                110
Glu Ser Lys Glu Lys Asp Arg Gln Val Leu Glu Asp Phe Pro Thr Ile 
         115                120                125
Ser Leu Glu Phe Arg Asn Leu Ala Glu Lys Tyr Gln Thr Val Ile Ala 
     130                135                140
Asp Ile Cys Arg Arg Met Gly Ile Gly Met Ala Glu Phe Leu Asp Lys 
 145                150                155                160
His Val Thr Ser Glu Gln Glu Trp Asp Lys Tyr Cys His Tyr Val Ala 
                 165                170                175
Gly Leu Val Gly Ile Gly Leu Ser Arg Leu Phe Ser Ala Ser Glu Phe 
             180                185                190
Glu Asp Pro Leu Val Gly Glu Asp Thr Glu Arg Ala Asn Ser Met Gly 
         195                200                205
Leu Phe Leu Gln Lys Thr Asn Ile Ile Arg Asp Tyr Leu Glu Asp Gln 
     210                215                220
Gln Gly Gly Arg Glu Phe Trp Pro Gln Glu Val Trp Ser Arg Tyr Val 
 225                230                235                240
Lys Lys Leu Gly Asp Phe Ala Lys Pro Glu Asn Ile Asp Leu Ala Val 
                 245                250                255
Gln Cys Leu Asn Glu Leu Ile Thr Asn Ala Leu His His Ile Pro Asp 
             260                265                270
Val Ile Thr Tyr Leu Ser Arg Leu Arg Asn Gln Ser Val Phe Asn Phe 
         275                280                285
Cys Ala Ile Pro Gln Val Met Ala Ile Ala Thr Leu Ala Ala Cys Tyr 
     290                295                300
Asn Asn Gln Gln Val Phe Lys Gly Ala Val Lys Ile Arg Lys Gly Gln 
 305                310                315                320
Ala Val Thr Leu Met Met Asp Ala Thr Asn Met Pro Ala Val Lys Ala 
                 325                330                335
Ile Ile Tyr Gln Tyr Met Glu Glu Ile Tyr His Arg Ile Pro Asp Ser 
             340                345                350
Asp Pro Ser Ser Ser Lys Thr Arg Gln Ile Ile Ser Thr Ile Arg Thr 
         355                360                365
Gln Asn Leu Pro Asn Cys Gln Leu Ile Ser Arg Ser His Tyr Ser Pro 
     370                375                380
Ile Tyr Leu Ser Phe Val Met Leu Leu Ala Ala Leu Ser Trp Gln Tyr 
 385                390                395                400
Leu Thr Thr Leu Ser Gln Val Thr Glu Asp Tyr Val Gln Thr Gly Glu 
                 405                410                415
His 
             420



<210> 4141
<211> 1662
<212> DNA
<213> Rattus norvegicus
<308> M95591
<400> 4141

ggccccgct  ctcgccctg  ctaccgccg  catctaaac  caggtggga  tgggagatc  60
cgacaggtg  gccccgcgc  ccgcagcca  aaggatgga  ttcgtgaag  gtctaggcc  120
cccggagga  ttctacaac  tgctgcgat  ccgcatggg  ggccggcgg  atttcatac  180
caagatgga  cggaactcg  tcagcaaca  cttgaagac  tgctataag  atcttgatc  240
gaccagtcg  agcttcgcc  cggttatcc  ggcgctgga  ggggacata  gtcatgcgg  300
gtgtgtgtt  tacctgatc  tccgagcca  ggacacagt  gaggatgac  tggccatca  360
tgtggagaa  aagatccca  tgctgcgaa  ctttcacac  ttcctctat  agccggagt  420
gcggttcac  gagagcaag  agaagcacc  agtagtgct  gaggacttc  ccacgatct  480
cctggagtt  agaaatttg  ctgagaaat  tcaaacagt  atcgctgac  tctgtcaca  540
gatgggatg  gggatggca  aatttctaa  caaggatgt  acctccaaa  aggactggg  600
caagtactg  cactatgtt  ctggactgg  gggaatcgg  ctttctcgc  tattctctg  660
ctcagagtt  gaagatccc  tagttggtg  agacacaga  tgtgccaat  ctatgggtc  720
gtttctgca  aaaacaaat  tcattcgtg  ttatctgga  gaccaacaa  aaggaagac  780
gttttggcc  caagaggta  ggggcaaat  tgttaagaa  ctggaagac  ttgttaagc  840
agagaacgt  gatgtggcc  tgaagtgct  gaatgaact  ataaccaac  ccctacaac  900
catccctga  gtcatcacc  acctgtcaa  gctccggaa  caaagtgtg  ttaacttct  960
tgccattcc  caggtaatg  ccattgcta  gctggctgc  tgttacaat  accatcagg  1020
attcaaggg  gtagtgaag  ttcggaagg  gcaagcagt  accctcatg  tggatgcca  1080
caacatgcc  gctgtcaaa  ctatcatat  ccagtacat  gaagagatt  atcaccggg  1140
ccccaactc  gacccgtca  ctagcaagg  caagcagct  atctccaac  tcaggacgc  1200
gagccttcc  aattgccag  tcatctccc  aagccacta  tcccccatt  acctgtcct  1260
catcatgct  ttggctgcc  tgagctggc  gtacttgag  actctgtcc  aggtcacag  1320
agactatgt  cagagagaa  actgacttt  tttagctgg  agcggaagt  cacgtgaag  1380
gggtttttc  tcttccccc  gctggattt  gacttccct  ggtttttcc  tctactcta  1440
tctttcgga  aactgagtg  gggaccttt  ggaactctg  agaggaaag  acgccttgc  1500
ctcagcagc  tggtgcttc  tggatgtgg  ccctgcctc  tgtagccac  ggcatcatg  1560
tgaccgaag  actggaaag  ccacatgtg  tcctagtga  cctggctag  atgctgatt  1620
aatctattt  atttgaaac  gcctttgaa  acctatcac  gt  1662



<210> 4142
<211> 416
<212> PRT
<213> Rattus norvegicus
<308> Q02769
<400> 4142

Met Glu Phe Val Lys Cys Leu Gly His Pro Glu Glu Phe Tyr Asn Leu 
  1               5                  10                  15
Leu Arg Phe Arg Met Gly Gly Arg Arg Asn Phe Ile Pro Lys Met Asp 
             20                  25                  30
Arg Asn Ser Leu Ser Asn Ser Leu Lys Thr Cys Tyr Lys Tyr Leu Asp 
         35                  40                  45
Gln Thr Ser Arg Ser Phe Ala Ala Val Ile Gln Ala Leu Asp Gly Asp 
     50                  55                  60
Ile Arg His Ala Val Cys Val Phe Tyr Leu Ile Leu Arg Ala Met Asp 
 65                  70                  75                  80
Thr Val Glu Asp Asp Met Ala Ile Ser Val Glu Lys Lys Ile Pro Leu 
                 85                  90                  95
Leu Arg Asn Phe His Thr Phe Leu Tyr Glu Pro Glu Trp Arg Phe Thr 
             100                105                110
Glu Ser Lys Glu Lys His Arg Val Val Leu Glu Asp Phe Pro Thr Ile 
         115                120                125
Ser Leu Glu Phe Arg Asn Leu Ala Glu Lys Tyr Gln Thr Val Ile Ala 
     130                135                140
Asp Ile Cys His Arg Met Gly Cys Gly Met Ala Glu Phe Leu Asn Lys 
 145                150                155                160
Asp Val Thr Ser Lys Gln Asp Trp Asp Lys Tyr Cys His Tyr Val Ala 
                 165                170                175
Gly Leu Val Gly Ile Gly Leu Ser Arg Leu Phe Ser Ala Ser Glu Phe 
             180                185                190
Glu Asp Pro Ile Val Gly Glu Asp Thr Glu Cys Ala Asn Ser Met Gly 
         195                200                205
Leu Phe Leu Gln Lys Thr Asn Ile Ile Arg Asp Tyr Leu Glu Asp Gln 
     210                215                220
Gln Glu Gly Arg Gln Phe Trp Pro Gln Glu Val Trp Gly Lys Tyr Val 
 225                230                235                240
Lys Lys Leu Glu Asp Phe Val Lys Pro Glu Asn Val Asp Val Ala Val 
                 245                250                255
Lys Cys Leu Asn Glu Leu Ile Thr Asn Ala Leu Gln His Ile Pro Asp 
             260                265                270
Val Ile Thr Tyr Leu Ser Arg Leu Arg Asn Gln Ser Val Phe Asn Phe 
         275                280                285
Cys Ala Ile Pro Gln Val Met Ala Ile Ala Thr Leu Ala Ala Cys Tyr 
     290                295                300
Asn Asn His Gln Val Phe Lys Gly Val Val Lys Ile Arg Lys Gly Gln 
 305                310                315                320
Ala Val Thr Leu Met Met Asp Ala Thr Asn Met Pro Ala Val Lys Ala 
                 325                330                335
Ile Ile Tyr Gln Tyr Ile Glu Glu Ile Tyr His Arg Val Pro Asn Ser 
             340                345                350
Asp Pro Ser Ala Ser Lys Ala Lys Gln Leu Ile Ser Asn Ile Arg Thr 
         355                360                365
Gln Ser Leu Pro Asn Cys Gln Leu Ile Ser Arg Ser His Tyr Ser Pro 
     370                375                380
Ile Tyr Leu Ser Phe Ile Met Leu Leu Ala Ala Leu Ser Trp Gln Tyr 
 385                390                395                400
Leu Ser Thr Leu Ser Gln Val Thr Glu Asp Tyr Val Gln Arg Glu His 
                 405                410                415



<210> 4143
<211> 1673
<212> DNA
<213> Homo sapiens
<308> S76822
<400> 4143

gccggtgag  gcctgggga  cgcagaggt  agagtcgcg  ccgggagtc  gccgcctgc  60
ccaggatgg  gttcgtgaa  tgccttggc  accccgaag  gttctacaa  ctggtgcgc  120
tccggatcg  gggcaagcg  aaggtgatg  ccaagatgg  ccaggactc  ctcagcagc  180
gcctgaaaa  ttgctacag  tatctcaat  agaccagtc  cagtttcgc  gctgttatc  240
aggcgctgg  tggggaaat  cgcaacgca  tgtgcatat  ttatctggt  ctccgagct  300
tggacacac  ggaagatga  atgaccatc  gtgtggaaa  gaaggtccc  ctgttacac  360
actttcact  tttccttta  caaccagac  ggcggttca  ggagagcaa  gagaaggat  420
gccaggtgc  ggaggactt  ccaacgatc  cccttgagt  tagaaatct  gctgagaaa  480
accaaacag  gattgccga  atttgccgg  gaatgggca  tgggatggc  gagtttttg  540
ataagcatg  gacctctga  caggagtgg  acaagtact  ccactatgt  gctgggctg  600
tcggaattg  cctttcccg  cttttctca  cctcagagt  tgaagaccc  ttagttggt  660
aagatacag  acgtgccaa  tctatgggc  tgtttctgc  gaaaacaaa  atcatccgt  720
actatctgg  agaccagca  ggaggaaga  agttctggc  tcaagaggt  tggagcagg  780
atgttaaga  gttagggga  tttgctaag  cggagaata  tgacttggc  gtgcagtgc  840
tgaatgaac  tataaccaa  gcactgcac  acatcccag  tgtcatcac  tacctttcg  900
gactcagaa  ccagagtgt  tttaacttc  gtgctattc  acaggtgat  gccattgcc  960
ctttggctg  ctgttataa  aaccagcag  tgttcaaag  ggcagtgaa  attcggaaa  1020
ggcaagcag  gaccctgat  atggatgcc  ccaatatgc  agctgtcaa  gccatcata  1080
atcagtata  ggaagagat  tatcataga  tccccgact  aaacccatc  tctagcaaa  1140
caaggcaga  catctccac  atccggacg  agaatcttc  caactgtca  ctgatttcc  1200
gaagccact  ctcccccat  tacctgtcg  ttgtcatgc  tttggctgc  ctgagctgg  1260
agtacctga  cactctctc  caggtaaca  aagactatg  tcagactgg  gaacactga  1320
cccaaattt  tccatagct  aagtccacc  taaagtgga  ttacttttt  tctctttat  1380
tttttccta  tactttaat  cctaaaaga  cgctgtgtg  ctgggacct  taggaaagt  1440
aaatgcagg  gagaagaac  taaacatga  aggtaaagg  tgcctcatc  cagcaacct  1500
tccttgtgg  tgatgatca  tgtgctgct  gtggctcat  gcagagcat  cagtgccac  1560
gtttaggtg  agtcgctgc  tatgtgact  tcatgagat  ctacttagt  tgatcctgg  1620
tagaatgat  attaaaagt  tttaatttg  agcaaaaaa  aaaaaaaaa  aaa  1673



<210> 4144
<211> 417
<212> PRT
<213> Homo sapiens
<308> P37268
<400> 4144

Met Glu Phe Val Lys Cys Leu Gly His Pro Glu Glu Phe Tyr Asn Leu 
  1               5                  10                  15
Val Arg Phe Arg Ile Gly Gly Lys Arg Lys Val Met Pro Lys Met Asp 
             20                  25                  30
Gln Asp Ser Leu Ser Ser Ser Leu Lys Thr Cys Tyr Lys Tyr Leu Asn 
         35                  40                  45
Gln Thr Ser Arg Ser Phe Ala Ala Val Ile Gln Ala Leu Asp Gly Glu 
     50                  55                  60
Met Arg Asn Ala Val Cys Ile Phe Tyr Leu Val Leu Arg Ala Leu Asp 
 65                  70                  75                  80
Thr Leu Glu Asp Asp Met Thr Ile Ser Val Glu Lys Lys Val Pro Leu 
                 85                  90                  95
Leu His Asn Phe His Ser Phe Leu Tyr Gln Pro Asp Trp Arg Phe Met 
             100                105                110
Glu Ser Lys Glu Lys Asp Arg Gln Val Leu Glu Asp Phe Pro Thr Ile 
         115                120                125
Ser Leu Glu Phe Arg Asn Leu Ala Glu Lys Tyr Gln Thr Val Ile Ala 
     130                135                140
Asp Ile Cys Arg Arg Met Gly Ile Gly Met Ala Glu Phe Leu Asp Lys 
 145                150                155                160
His Val Thr Ser Glu Gln Glu Trp Asp Lys Tyr Cys His Tyr Val Ala 
                 165                170                175
Gly Leu Val Gly Ile Gly Leu Ser Arg Leu Phe Ser Ala Ser Glu Phe 
             180                185                190
Glu Asp Pro Leu Val Gly Glu Asp Thr Glu Arg Ala Asn Ser Met Gly 
         195                200                205
Leu Phe Leu Gln Lys Thr Asn Ile Ile Arg Asp Tyr Leu Glu Asp Gln 
     210                215                220
Gln Gly Gly Arg Glu Phe Trp Pro Gln Glu Val Trp Ser Arg Tyr Val 
 225                230                235                240
Lys Lys Leu Gly Asp Phe Ala Lys Pro Glu Asn Ile Asp Leu Ala Val 
                 245                250                255
Gln Cys Leu Asn Glu Leu Ile Thr Asn Ala Leu His His Ile Pro Asp 
             260                265                270
Val Ile Thr Tyr Leu Ser Arg Leu Arg Asn Gln Ser Val Phe Asn Phe 
         275                280                285
Cys Ala Ile Pro Gln Val Met Ala Ile Ala Thr Leu Ala Ala Cys Tyr 
     290                295                300
Asn Asn Gln Gln Val Phe Lys Gly Ala Val Lys Ile Arg Lys Gly Gln 
 305                310                315                320
Ala Val Thr Leu Met Met Asp Ala Thr Asn Met Pro Ala Val Lys Ala 
                 325                330                335
Ile Ile Tyr Gln Tyr Met Glu Glu Ile Tyr His Arg Ile Pro Asp Ser 
             340                345                350
Asp Pro Ser Ser Ser Lys Thr Arg Gln Ile Ile Ser Thr Ile Arg Thr 
         355                360                365
Gln Asn Leu Pro Asn Cys Gln Leu Ile Ser Arg Ser His Tyr Ser Pro 
     370                375                380
Ile Tyr Leu Ser Phe Val Met Leu Leu Ala Ala Leu Ser Trp Gln Tyr 
 385                390                395                400
Leu Thr Thr Leu Ser Gln Val Thr Glu Asp Tyr Val Gln Thr Gly Glu 
                 405                410                415
His 
             420



<210> 4145
<211> 1616
<212> DNA
<213> Rattus norvegicus
<308> M95768
<400> 4145

atggcgctg  gtgacctcc  ggaactcac  ctgctgctg  tgctgcccc  gctggagcg  60
ctctcggcc  aggactgcc  gtgctccga  gcttctctc  gccgaccga  ccgccacca  120
cgcgacttc  aggtctttg  gtttgatgt  ggacagaaa  cctggaaat  ttatgactg  180
tcgcagatt  cgactgtgg  agtttttgg  aaatatgac  cagaactta  gtgctatgc  240
cattcgaaa  gagccaggg  agtgctaaa  ggtgatgtg  ccctgaagg  catcattaa  300
cctaccttc  gagcgtcat  gatagcgca  aaagttgcc  tagccaaag  acaacacat  360
gatggaatt  atatagaca  agaacagga  gttgattgc  cgtcacctg  atatgaagc  420
ttgacagct  tggtcagag  aaccacaga  ggtttccat  gtgagattg  gggatcaca  480
gtaactttt  atgtagctt  gtcaccaaa  ggcatagac  aaaggtgct  taattatac  540
gggattgcg  atgcctgcg  ctttctttt  gtgatgtct  acgatgagc  aagtcagat  600
tggtcagaa  gtattgcag  cgccaatgc  ccctacaat  agacattaa  tggatatgg  660
gactacctc  ggatgggca  cagccccag  aaacttgta  tgggtattc  ctggtatgg  720
tatgattac  tttgcctaa  cctctcaaa  gatgatgtc  gcgccattg  aaaggtccc  780
ttcagaggg  ctccttgca  tgatgctgc  gggcatcag  tgccctaca  ggtcatcat  840
aagcaagta  acagttctg  ttctggaag  cagtggaac  aagaccagc  agctccgta  900
tataattac  aggatccca  tggccgttt  catcaggtg  ggtacgata  cccccggag  960
atctcacta  aggcagcat  cgtcaaaca  tacggcttg  ggggcattg  catgtggaa  1020
gcgaactgt  tggactact  agatgacgc  ctagccaga  agcaaacgg  ggaaatgtg  1080
ggagccctg  gaccacggc  gtgatacat  cagaggaat  tcttttgtc  gacggttag  1140
tttgcagga  tggcctgtg  aagcagatc  acctcttca  gagataaaa  tatatattt  1200
gtcatgtta  cctaactta  ttattggtc  actcaatac  caggaaaga  ataaagaaa  1260
tattcattt  tacttggaa  atacataca  atcttaaat  tccaggaat  taaaagcaa  1320
aacaagtca  cttactcta  taaatattc  tctgtttca  tattataat  atattatat  1380
ataattaga  aagttgctt  tagaattcc  tgctgaatt  ttcctcctg  tattaaaat  1440
tactgttaa  aaccaatag  gatttttaa  aatgtataa  tagtagaca  gtgaagata  1500
tggagaagg  agtgcacat  accatagtg  gttacacac  tgtatagac  atcatagta  1560
agcccatta  ttttataat  aatatatgc  aataaaaga  gtgtaactt  aaatgg  1616



<210> 4146
<211> 367
<212> PRT
<213> Rattus norvegicus
<308> Q01460
<400> 4146

Met Ala Leu Ser Asp Leu Leu Glu Leu Thr Leu Leu Leu Leu Leu Pro 
  1               5                  10                  15
Leu Leu Glu Arg Leu Ser Ala Glu Asp Cys Pro Cys Ser Glu Ala Ser 
             20                  25                  30
Leu Cys Arg Pro Ile Arg His His Arg Asp Phe Glu Val Phe Val Phe 
         35                  40                  45
Asp Val Gly Gln Lys Thr Trp Lys Ser Tyr Asp Trp Ser Gln Ile Thr 
     50                  55                  60
Thr Val Ala Val Phe Gly Lys Tyr Asp Ser Glu Leu Met Cys Tyr Ala 
 65                  70                  75                  80
His Ser Lys Gly Ala Arg Val Val Leu Lys Gly Asp Val Ala Leu Lys 
                 85                  90                  95
Asp Ile Ile Asn Pro Thr Phe Arg Ala Ser Trp Ile Ala Gln Lys Val 
             100                105                110
Ala Leu Ala Lys Ala Gln His Met Asp Gly Ile Asn Ile Asp Ile Glu 
         115                120                125
Gln Glu Val Asp Cys Ser Ser Pro Glu Tyr Glu Ala Leu Thr Ala Leu 
     130                135                140
Val Arg Glu Thr Thr Glu Gly Phe His Arg Glu Ile Glu Gly Ser Gln 
 145                150                155                160
Val Thr Phe Asp Val Ala Trp Ser Pro Lys Gly Ile Asp Lys Arg Cys 
                 165                170                175
Tyr Asn Tyr Thr Gly Ile Ala Asp Ala Cys Asp Phe Leu Phe Val Met 
             180                185                190
Ser Tyr Asp Glu Gln Ser Gln Ile Trp Ser Glu Cys Ile Ala Ala Ala 
         195                200                205
Asn Ala Pro Tyr Asn Gln Thr Leu Thr Gly Tyr Gly Asp Tyr Leu Arg 
     210                215                220
Met Gly Ile Ser Pro Arg Lys Leu Val Met Gly Ile Pro Trp Tyr Gly 
 225                230                235                240
Tyr Asp Tyr Ile Cys Leu Asn Leu Ser Lys Asp Asp Val Cys Ala Ile 
                 245                250                255
Ala Lys Val Pro Phe Arg Gly Ala Pro Cys Ser Asp Ala Ala Gly His 
             260                265                270
Gln Val Pro Tyr Arg Val Ile Met Lys Gln Val Asn Ser Ser Val Ser 
         275                280                285
Gly Ser Gln Trp Asn Gln Asp Gln Gln Ala Pro Tyr Tyr Asn Tyr Lys 
     290                295                300
Asp Pro Thr Gly Arg Leu His Gln Val Trp Tyr Asp Asn Pro Arg Ser 
 305                310                315                320
Ile Ser Leu Lys Ala Ala Phe Val Lys His Tyr Gly Leu Arg Gly Ile 
                 325                330                335
Gly Met Trp Asn Ala Asn Cys Leu Asp Tyr Ser Asp Asp Ala Leu Ala 
             340                345                350
Arg Glu Gln Thr Glu Glu Met Trp Gly Ala Leu Arg Pro Arg Leu 
         355                360                365



<210> 4147
<211> 1618
<212> DNA
<213> Homo sapiens
<308> NM_004388
<400> 4147

atgtcccgg  cgcagcttc  acgctggcg  ctcgtctct  gcccgccga  cggcgtccc  60
ggtctagcg  tgctggcgc  gctggcgct  ctggcgctg  ggctcgcgg  cgggaccga  120
tgcccatgc  cggagcctg  gctctgccg  ccgattcgc  accatccag  tttcgaggt  180
tttgtgttt  atgttggac  gaaaacttg  aaatcttat  attggtcac  gattacaac  240
gtggcaaca  ttggaaaat  tgactcaga  cttatgtgc  acgctcatt  aaaaggagc  300
agagtagta  ttaaaggag  tgtatcctt  aaggatatc  ttgatcctg  tttcagagc  360
tcctggata  ctcaaaaac  taatttggc  aaaacacaa  atatggatg  aattaatat  420
gatatagag  aagaagtta  ttgtttatc  cctgaatat  atgcattaa  tgctttagt  480
aaagaaact  cagactctt  ccatcgtga  attgaggga  cacaggtaa  ctttgatgt  540
gcttggtct  caaagaaca  agacagaag  tgctataat  atactggaa  cgcagatgc  600
tgtgacttc  tctttgtga  gtcttatga  gaacaaagt  agatctggt  agaatgtat  660
gcagcagcc  atgctccct  taatcagac  ttaactgga  ataatgact  catcaagat  720
agcattaat  ctaagaaac  tgtaatggg  gttccttgg  atggttatg  ttatacctg  780
ctgaatctg  ctgaggatc  tgtttgtac  attgcaaaa  tccctttcc  gggggctcc  840
tgtagtgac  ctgcaggac  tcaggtgcc  tacaaaacg  tcatgaagc  aataaatag  900
tctatttct  gaaacctat  ggataaaga  cagcgggct  cttattata  ctataaaga  960
cctgctggc  actttcatc  agtatggta  gataaccct  agagtattt  tttaaaggc  1020
acatatata  aaaactatc  cttacgggg  attggcatg  ggaatgcaa  ctgtcttga  1080
tactctgga  atgctgtag  caaacagca  actgaagaa  tgtgggaag  cttaaagcc  1140
aagctgtta  agagatgaa  atcttttgt  aaaccatta  gagttagaa  gatgatctg  1200
atcaacaga  ctagtttct  gcattttta  tatgttgct  tatactttt  ttatccgta  1260
actaaaaaa  aagaataaa  aaatgtttt  attgtttga  tttgaaaaa  acacacgaa  1320
gtcctcagt  tccaggaac  taaaggcaa  aagcaagtc  acttaccta  taaatattc  1380
tctattaga  gtttcaaca  tataattta  ttgggaaaa  ttgctttca  aattttatt  1440
tgccatatt  cccttcatt  tagtaaaat  tatgctcac  aatcaatgc  gatttttaa  1500
atatgtata  tctgaagtg  aaattgttt  cttagagtt  ttaaaaacc  agtctttga  1560
aagcagttt  tgctatact  ttcccccaa  cctccaata  atcttaaat  taaaacct  1618



<210> 4148
<211> 385
<212> PRT
<213> Homo sapiens
<308> Q01459
<400> 4148

Met Ser Arg Pro Gln Leu Arg Arg Trp Arg Leu Val Ser Ser Pro Pro 
  1               5                  10                  15
Ser Gly Val Pro Gly Leu Ala Leu Leu Ala Leu Leu Ala Leu Leu Ala 
             20                  25                  30
Leu Arg Leu Ala Ala Gly Thr Asp Cys Pro Cys Pro Glu Pro Glu Leu 
         35                  40                  45
Cys Arg Pro Ile Arg His His Pro Asp Phe Glu Val Phe Val Phe Asp 
     50                  55                  60
Val Gly Gln Lys Thr Trp Lys Ser Tyr Asp Trp Ser Gln Ile Thr Thr 
 65                  70                  75                  80
Val Ala Thr Phe Gly Lys Tyr Asp Ser Glu Leu Met Cys Tyr Ala His 
                 85                  90                  95
Ser Lys Gly Ala Arg Val Val Leu Lys Gly Asp Val Ser Leu Lys Asp 
             100                105                110
Ile Ile Asp Pro Ala Phe Arg Ala Ser Trp Ile Ala Gln Lys Leu Asn 
         115                120                125
Leu Ala Lys Thr Gln Tyr Met Asp Gly Ile Asn Ile Asp Ile Glu Gln 
     130                135                140
Glu Val Asn Cys Leu Ser Pro Glu Tyr Asp Ala Leu Thr Ala Leu Val 
 145                150                155                160
Lys Glu Thr Thr Asp Ser Phe His Arg Glu Ile Glu Gly Ser Gln Val 
                 165                170                175
Thr Phe Asp Val Ala Trp Ser Pro Lys Asn Ile Asp Arg Arg Cys Tyr 
             180                185                190
Asn Tyr Thr Gly Ile Ala Asp Ala Cys Asp Phe Leu Phe Val Met Ser 
         195                200                205
Tyr Asp Glu Gln Ser Gln Ile Trp Ser Glu Cys Ile Ala Ala Ala Asn 
     210                215                220
Ala Pro Tyr Asn Gln Thr Leu Thr Gly Tyr Asn Asp Tyr Ile Lys Met 
 225                230                235                240
Ser Ile Asn Pro Lys Lys Leu Val Met Gly Val Pro Trp Tyr Gly Tyr 
                 245                250                255
Asp Tyr Thr Cys Leu Asn Leu Ser Glu Asp His Val Cys Thr Ile Ala 
             260                265                270
Lys Val Pro Phe Arg Gly Ala Pro Cys Ser Asp Ala Ala Gly Arg Gln 
         275                280                285
Val Pro Tyr Lys Thr Ile Met Lys Gln Ile Asn Ser Ser Ile Ser Gly 
     290                295                300
Asn Leu Trp Asp Lys Asp Gln Arg Ala Pro Tyr Tyr Asn Tyr Lys Asp 
 305                310                315                320
Pro Ala Gly His Phe His Gln Val Trp Tyr Asp Asn Pro Gln Ser Ile 
                 325                330                335
Ser Leu Lys Ala Thr Tyr Ile Gln Asn Tyr Arg Leu Arg Gly Ile Gly 
             340                345                350
Met Trp Asn Ala Asn Cys Leu Asp Tyr Ser Gly Asp Ala Val Ala Lys 
         355                360                365
Gln Gln Thr Glu Glu Met Trp Glu Val Leu Lys Pro Lys Leu Leu Gln 
     370                375                380
Arg 
 385



<210> 4149
<211> 2462
<212> DNA
<213> Rattus norvegicus
<308> M96375
<400> 4149

ttttttttc  cttttcttt  ttttctttt  cttttcttt  ttcacctct  cgctttctc  60
tctgctcct  cttttcctc  gctcgattc  cccagttcg  tcccagcta  cttcacaag  120
gtgccctct  ccctctgaa  ccatcgccg  gcgtaagtg  caggaggcg  cggactcgg  180
gattgcctc  ggagcaggc  atgcgcgcc  ctgctctgc  cgctgcccg  gggaggctg  240
cgggagctg  agagctggc  agggctgaa  ggagggaag  ggtgcctcg  gtccatggg  300
tctgcttct  tcctgaaag  aggctggac  ggcgaagtg  tctccccgt  ccccacgca  360
aatgctaaa  ggatttacc  agtggattc  cggtggatg  ctgtcatgt  gaagtgaag  420
ccctccggg  ggagcttta  acaatttcc  ggctcccca  ccccggcac  cactctcac  480
cgaaactct  ggggagtat  tctggagaa  ctggaaccc  gcaaacctg  gagcagcca  540
cctctctgc  cttgctgtt  ttcggggct  cctttctgg  caagtcccc  ctgccagct  600
cattcacct  ggctatgtt  cggattgtt  ggggtgtag  gtacggcag  ctccagcac  660
tcgagaaga  tgtccgaaa  agggagagg  tgggtgccc  ggcgcggtg  ggcggccag  720
cccgcagcc  accgcgagc  gccggattc  cggcttcct  gcctcttct  gtgccccaa  780
ctttgtctc  cgcggcggc  gccccttgg  gggcgcccc  ccatgtacc  gaggatgct  840
cggtgcggt  ccgagctgg  atcgcccgg  ggcggcagt  gtggcggcg  aggggggcg  900
ctggccctg  tctggatag  cccgctcac  ctcagcggc  tcctaggag  ggcctgggg  960
gcatccagt  tgggagcgc  ccacatcca  catttccat  gcagcagca  gcatcattc  1020
gtgcctatt  caatctaca  gtcaccagc  tccttgcga  gcggacacg  tgggacgac  1080
tatatcttt  gcaaaggtg  tggacaaat  acatataag  ggcctccta  tgaccgacc  1140
agtacacga  cagacaggc  ggccatcgg  tttagcact  ttcagaagg  agcagtgtt  1200
gtgcgtgtg  acagttcct  aggcctggg  gactacctt  agctgcaca  acaccaagg  1260
aaaattgga  ttaaattta  tgttgggac  gatgacatc  ccattgagg  gtccaatgc  1320
atcattaat  atggaaaat  ccatgtagt  cgtttcacg  ggagtggtg  caatgccac  1380
ttacaggtg  acagctggc  agtcatcga  cgataccct  caggaaaca  tgataacga  1440
cgcctggcg  ttgctagac  gcgaattcc  tatcgactt  gtcgagtag  tgatgaatg  1500
ctactcgac  aagggcgtc  gctcacaat  ttcaatagc  aagcaacca  aataattgg  1560
gggaaagag  agggccagc  cttccaggg  cagctctct  ggctttact  caatggctt  1620
aaagttctg  atatggcgg  agagaacga  gccaacatc  ccatagtgg  aaatgtgag  1680
ctggtcggt  aagtgcctt  ctctatgac  actgagtcg  cagccactg  catgcagtc  1740
gagatgtcc  cctcaatca  ggagaccac  acaaccctg  ctaccagca  agctcgacg  1800
ggaaagccc  ccacaaagg  gcctatcag  cagaccacg  atgatatcc  tgtggcctc  1860
gcagagtgt  ccagcgacg  tgaggacat  gacccctgt  agccgagct  aggtgggtt  1920
gccaacccc  cccgagtgg  cggccgcga  ccataccca  gctcggcag  ggtgatccg  1980
gagtctagc  gtaccactg  catggtggt  gggattgtc  cagcagcag  tctgtgcat  2040
ctcatcctc  tctatgcca  gtacaagta  agaaaccgg  atgaaggct  atatcacgt  2100
gatgagagt  gaaactaca  cagtaactc  gcacagtcc  atggggctg  ggtcaagga  2160
aagcagccc  gcagtgcga  aagcgccaa  aaaaacaag  agaacaagg  taaggagta  2220
tatgtctga  ctcaagatt  gaaaaggac  cttgtatag  aatagtctt  attttatct  2280
agacataat  taaacttat  tactttcct  tttatgaag  acatacaaa  gaagacagg  2340
aatgcgatc  ggagggaaa  ctcttttta  aaaaaaaca  acaagtatg  catgctctt  2400
tttctcaaa  aaaaaacat  cacaaaaaa  aggaaagag  gaaaaaaaa  aaaaaggaa  2460
tc  2462



<210> 4150
<211> 468
<212> PRT
<213> Rattus norvegicus
<308> Q63373
<400> 4150

Met Tyr Gln Arg Met Leu Arg Cys Gly Ala Glu Leu Gly Ser Pro Gly 
  1               5                  10                  15
Gly Gly Ser Ser Gly Gly Ala Gly Gly Arg Leu Ala Leu Leu Trp Ile 
             20                  25                  30
Val Pro Leu Thr Leu Ser Gly Leu Leu Gly Val Ala Trp Gly Ala Ser 
         35                  40                  45
Ser Leu Gly Ala His His Ile His His Phe His Gly Ser Ser Lys His 
     50                  55                  60
His Ser Val Pro Ile Ala Ile Tyr Arg Ser Pro Ala Ser Leu Arg Gly 
 65                  70                  75                  80
Gly His Ala Gly Thr Thr Tyr Ile Phe Ser Lys Gly Gly Gly Gln Ile 
                 85                  90                  95
Thr Tyr Lys Trp Pro Pro Asn Asp Arg Pro Ser Thr Arg Ala Asp Arg 
             100                105                110
Leu Ala Ile Gly Phe Ser Thr Val Gln Lys Glu Ala Val Leu Val Arg 
         115                120                125
Val Asp Ser Ser Ser Gly Leu Gly Asp Tyr Leu Glu Leu His Ile His 
     130                135                140
Gln Gly Lys Ile Gly Val Lys Phe Asn Val Gly Thr Asp Asp Ile Ala 
 145                150                155                160
Ile Glu Glu Ser Asn Ala Ile Ile Asn Asp Gly Lys Tyr His Val Val 
                 165                170                175
Arg Phe Thr Arg Ser Gly Gly Asn Ala Thr Leu Gln Val Asp Ser Trp 
             180                185                190
Pro Val Ile Glu Arg Tyr Pro Ala Gly Asn Asn Asp Asn Glu Arg Leu 
         195                200                205
Ala Ile Ala Arg Gln Arg Ile Pro Tyr Arg Leu Gly Arg Val Val Asp 
     210                215                220
Glu Trp Leu Leu Asp Lys Gly Arg Gln Leu Thr Ile Phe Asn Ser Gln 
 225                230                235                240
Ala Thr Ile Ile Ile Gly Gly Lys Glu Gln Gly Gln Pro Phe Gln Gly 
                 245                250                255
Gln Leu Ser Gly Leu Tyr Tyr Asn Gly Leu Lys Val Leu Asn Met Ala 
             260                265                270
Ala Glu Asn Asp Ala Asn Ile Ala Ile Val Gly Asn Val Arg Leu Val 
         275                280                285
Gly Glu Val Pro Ser Ser Met Thr Thr Glu Ser Thr Ala Thr Ala Met 
     290                295                300
Gln Ser Glu Met Ser Thr Ser Ile Met Glu Thr Thr Thr Thr Leu Ala 
 305                310                315                320
Thr Ser Thr Ala Arg Arg Gly Lys Pro Pro Thr Lys Glu Pro Ile Ser 
                 325                330                335
Gln Thr Thr Asp Asp Ile Leu Val Ala Ser Ala Glu Cys Pro Ser Asp 
             340                345                350
Asp Glu Asp Ile Asp Pro Cys Glu Pro Ser Ser Gly Gly Leu Ala Asn 
         355                360                365
Pro Thr Arg Val Gly Gly Arg Glu Pro Tyr Pro Gly Ser Ala Glu Val 
     370                375                380
Ile Arg Glu Ser Ser Ser Thr Thr Gly Met Val Val Gly Ile Val Ala 
 385                390                395                400
Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu Tyr Ala Met Tyr Lys Tyr 
                 405                410                415
Arg Asn Arg Asp Glu Gly Ser Tyr His Val Asp Glu Ser Arg Asn Tyr 
             420                425                430
Ile Ser Asn Ser Ala Gln Ser Asn Gly Ala Val Val Lys Glu Lys Gln 
         435                440                445
Pro Ser Ser Ala Lys Ser Ala Asn Lys Asn Lys Lys Asn Lys Asp Lys 
     450                455                460
Glu Tyr Tyr Val 
 465



<210> 4151
<211> 3069
<212> DNA
<213> Homo sapiens
<308> AF064842
<400> 4151

cttttttct  tttcttttt  tttttctgt  tctctccct  actccttcg  ctgcatctt  60
ttctcagct  cctttccgc  gttcgattc  cacttcctt  agaagggcg  actcttgcc  120
ctgaacccc  cgccgggcg  aagtgtcag  aggcggcgg  cgcggagat  gcctcggga  180
caggcgatg  gcgccgctg  tccgcgcgc  gcccggggg  ggctggcgc  agcgggcga  240
ccggccggg  ctgaatgga  ggaaggggc  cctggattc  atggggtct  cttctgtct  300
gaaaggagg  tgggccggc  aagtggcct  cctagtccc  gcacacaaa  ctaaatgga  360
ttacctagt  gattcgcgg  ggatgtctg  catgtagaa  tgaggacct  caggaggag  420
tttaaacaa  ttctcggcc  cccacccgc  ggcacgcac  ctcgcccga  actctttgg  480
agtatctct  gagaacctg  agccctgga  atctgggag  agccacccg  tccgcgctt  540
ctgttcccg  ggctgcctt  ccggacaag  ccctctcca  ctgcattcg  ctcggctat  600
tttcggatt  tttggggtg  taggcacgg  ggactccag  accccgaga  gactgtccg  660
aggagggag  ggatgggtg  cctggcgcg  tgaggcggc  ggcccctca  cccactccg  720
gccgcccgc  cccctgcgc  ctctcctct  cccgcgccc  aaactttgc  tcccgcggc  780
gctgcccct  ggcgggcgc  ccgccatgt  ccagaggat  ctccggtgc  gcgccgagc  840
gggctcgcc  gggggcggc  gccgcggcg  cggcggcgg  ggcgcaggg  ggcgcctgg  900
cctgctttg  atagtcccg  tcaccctca  cggcctcct  cgagtggcg  ggggggcat  960
cagttttgg  agcgcacca  atccaccat  tccatggca  cagcaagca  cattcagtg  1020
ctattgcaa  ctacaggtc  ccggcatcc  tgcgaggcg  acacgctgg  acgacatat  1080
tctttagca  aggtggtgg  caaatcacg  ataagtggc  tcctaatga  cgacccagt  1140
cacgagcag  cagactggc  ataggtttt  gcactgttc  gaaagaagc  gtattggtg  1200
gagtggaca  ttcttcagg  ttgggtgac  acctagaac  gcatataca  cagggaaaa  1260
ttggagtta  gtttaatat  gggacagat  acatcgcca  tgaagaatc  aatgcaatc  1320
ttaatgatg  gaaatacca  gtagttcgt  tcacgagga  tggtggcaa  gccacgttg  1380
aggtggaca  ctggccagt  atcgagcgg  accctgcag  gcgtcagct  acaatcttc  1440
atagccaag  aaccataat  attggcggg  aagagcagg  ccagccctt  cagggccag  1500
tctctgggc  gtactacaa  ggcttgaaa  ttctgaata  ggcagccga  aacgatgcc  1560
acatcgcca  agtgggaga  gtgagactg  ttggtgaag  gccttcctc  ntgacaact  1620
agtcaacag  cactgccat  caatcagag  tgtccacat  aattatgga  actaccacg  1680
ccctggcta  tagcacagc  agaagagga  agcccccga  aaaagaacc  attagccag  1740
ccacaggtg  catccttgt  gcctcagca  agtgtccca  cgatgatga  gacattgac  1800
cctgtgagc  gagctcagg  gggttagcc  acccaaccc  agcaggcgg  agagagccg  1860
atccaggct  agcagaagt  atccgggag  ccagcagca  cacgggtat  gtcgttggg  1920
tagtagccg  tgccgccct  tgcatcctt  tcctcctct  tgccatgaa  aagtgcaga  1980
accgggatg  aggctcata  catgtggac  agagtcgaa  ctacatcag  aactcagca  2040
agtccaatg  ggctgttgt  aaggagaaa  aacccagca  tgcgaaaag  tccaacaaa  2100
ataagaaaa  caaggataa  gagtattat  tctgatccc  agatcttaa  tggacactt  2160
tatagaaat  gtcttcatt  tatctgaga  ataatataa  cttatttac  ttccttttt  2220
tgaagcaca  acaaaagaa  acagggaat  caatcagga  ggaaagact  tttaaaaaa  2280
aaaaacaag  atctcatgc  cttgtttct  aaaaaagaa  aacaaaaaa  aaaaaacag  2340
gggccaata  attccctaa  atccacagt  ttttcattt  ctctgcttg  ctttatgtt  2400
ctgggacat  tctaaaaga  agtgatgac  gcacgcatt  ataaagcaa  ggagtagta  2460
agcatcaag  cacgacaca  aaaccaaca  aaaacataa  acaaaaaag  agctaccta  2520
gatcctgga  ttagccaaa  tgctagcgc  ttcctgaga  gtcagtcca  ttgccagag  2580
agactgtcc  tttgagtga  tcaacctgc  aacctttaa  agtttgccg  ctggtgcaa  2640
tggagcagt  gttggcact  gcatatgaa  caaagtgct  gcttttttg  agacttgtg  2700
aggaacaca  tcaaaaagc  cctttctgg  tgtgagaga  gaaaaaaaa  tatggaggc  2760
ttattttca  aaatgtgaa  tataaggca  gttttcaca  aaaatttca  aacaaaaac  2820
agagggcat  gatgcaatc  ttgggaaat  ttcatgcac  cttattatg  tattacata  2880
gtttatata  aatccatct  tgtgtgctt  ctggactgt  ataagtgac  ttttatagc  2940
tgttgtata  aaaatgcga  atatatctc  gctcttcag  catttttgg  aaagtcaat  3000
ttataagtg  tgctaagta  agggagttt  atgacatca  agcaacaat  atttcagtt  3060
gatttttcg  3069



<210> 4152
<211> 442
<212> PRT
<213> Homo sapiens
<308> P58400
<400> 4152

Met Tyr Gln Arg Met Leu Arg Cys Gly Ala Glu Leu Gly Ser Pro Gly 
  1               5                  10                  15
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Gly Arg Leu Ala 
             20                  25                  30
Leu Leu Trp Ile Val Pro Leu Thr Leu Ser Gly Leu Leu Gly Val Ala 
         35                  40                  45
Trp Gly Ala Ser Ser Leu Gly Ala His His Ile His His Phe His Gly 
     50                  55                  60
Ser Ser Lys His His Ser Val Pro Ile Ala Ile Tyr Arg Ser Pro Ala 
 65                  70                  75                  80
Ser Leu Arg Gly Gly His Ala Gly Thr Thr Tyr Ile Phe Ser Lys Gly 
                 85                  90                  95
Gly Gly Gln Ile Thr Tyr Lys Trp Pro Pro Asn Asp Arg Pro Ser Thr 
             100                105                110
Arg Ala Asp Arg Leu Ala Ile Gly Phe Ser Thr Val Gln Lys Glu Ala 
         115                120                125
Val Leu Val Arg Val Asp Ser Ser Ser Gly Leu Gly Asp Tyr Leu Glu 
     130                135                140
Leu His Ile His Gln Gly Lys Ile Gly Val Lys Phe Asn Ile Gly Thr 
 145                150                155                160
Asp Asp Ile Ala Ile Glu Glu Ser Asn Ala Ile Ile Asn Asp Gly Lys 
                 165                170                175
Tyr His Val Val Arg Phe Thr Arg Ser Gly Gly Asn Ala Thr Leu Gln 
             180                185                190
Val Asp Ser Trp Pro Val Ile Glu Arg Tyr Pro Ala Gly Arg Gln Leu 
         195                200                205
Thr Ile Phe Asn Ser Gln Ala Thr Ile Ile Ile Gly Gly Lys Glu Gln 
     210                215                220
Gly Gln Pro Phe Gln Gly Gln Leu Ser Gly Leu Tyr Tyr Asn Gly Leu 
 225                230                235                240
Lys Val Leu Asn Met Ala Ala Glu Asn Asp Ala Asn Ile Ala Ile Val 
                 245                250                255
Gly Asp Val Arg Leu Val Gly Glu Val Pro Ser Ser Xaa Thr Thr Glu 
             260                265                270
Ser Thr Ala Thr Ala Met Gln Ser Glu Met Ser Thr Ser Ile Met Glu 
         275                280                285
Thr Thr Thr Thr Leu Ala Thr Ser Thr Ala Arg Arg Gly Lys Pro Pro 
     290                295                300
Thr Lys Glu Pro Ile Ser Gln Thr Thr Gly Asp Ile Leu Val Ala Ser 
 305                310                315                320
Ala Glu Cys Pro Ser Asp Asp Glu Asp Ile Asp Pro Cys Glu Pro Ser 
                 325                330                335
Ser Gly Gly Leu Ala Asn Pro Thr Arg Ala Gly Gly Arg Glu Pro Tyr 
             340                345                350
Pro Gly Ser Ala Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met 
         355                360                365
Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu 
     370                375                380
Cys Ala Met Asn Lys Cys Arg Asn Arg Asp Glu Gly Ser Tyr His Val 
 385                390                395                400
Asp Glu Ser Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Ala 
                 405                410                415
Val Val Lys Glu Lys Gln Pro Ser Ser Ala Lys Ser Ser Asn Lys Asn 
             420                425                430
Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val 
         435                440



<210> 4153
<211> 2489
<212> DNA
<213> Rattus norvegicus
<308> M96601
<400> 4153

gccaacgcc  cgatcgccg  caatcccgc  agcctcggg  cgggccatc  gctgtgggc  60
tagccaccc  gatgcagag  cagtgccac  gcctcttca  aggagcctc  caagcaaaa  120
gaggagatg  ccaccaagg  gaagcttca  tgtctgaaa  acttccaca  agacatcct  180
aagccttct  cagggaaga  cccaggcac  cggcctgag  atgaggctg  tgggaagcc  240
cctcagagg  agaagtggt  cagcaagat  gactttgtg  tgtctgtgg  cggaggctt  300
gtgggtttg  gcaatgtct  gcgtttccc  tacctctgc  acaaaaatg  tggaggtgc  360
ttcctcata  cgtatttta  tttcctgtt  gggagcggc  tgcctgtgt  tttcctgga  420
gtcatcata  gccagtaca  ctcagaagg  ggcatcacc  gctgggaga  gatctgccc  480
ttgttctct  gcattggct  cgcgtccat  gtcatcgtg  ccctcctga  tgtgtacta  540
atcgtcatc  tggcctggg  cacatacta  ctattccag  ctttccaga  ggatcttcc  600
tgggcccac  gcaaccata  ctggaacac  ccacagtgc  tggaggaca  cctgcgtag  660
aacgagagt  actgggtct  ccttagcgc  gccaacttc  cttcgcctg  gatcgagtt  720
tgggagcgc  acgtgctca  cctgtcctc  ggaatcgac  acccaggca  tctgaaatg  780
gacctcgcg  tctgcctcc  cttagtctg  ctcgtctgt  ttttctgca  ctggaaggg  840
gttcggtcc  caggcaagg  tgtctactt  actgctact  tcccgtttg  catgcttct  900
gtgctgctg  tccgtggac  gaccctgcc  ggtgctggt  aaggcatca  attctacct  960
taccctaac  tcagccgcc  tgaggaccc  caggtgtgg  tcgacgctg  aactcagat  1020
ttcttttcc  acgctatct  cctgggggc  atgacctca  tgggaagct  taacaagta  1080
aagtataac  cgtacaggg  ctgtatgct  ctgggatgc  tgaacagtg  taccagttt  1140
gtgtctggc  tcgcaattt  ttccatcct  ggcttcatg  cacaagagc  aggggtgga  1200
attgctgat  tggctgagt  aggtcctgg  ttggccttc  ttgcctacc  aaaagctgt  1260
accatgatg  cgctgccca  cttttggtc  attctgttt  ttattatgc  cctcttgct  1320
ggactggac  gccagtttg  tgaagtcga  ggacagatc  catccttgg  tgatcttta  1380
ccgtccttc  taaggaagg  ttatcgtcg  gaaatcttc  ttgccatcg  gtgcagcat  1440
agctacctg  tggggctga  gatggtgac  gagggtggc  tgtatgtgt  tcaactctt  1500
gactactat  cagctagtg  tgtatgcct  ttgtgggtc  cattctttg  atgttttgt  1560
attgcctgg  tatatggcg  tgataactt  tatgacggt  ttgaggaca  gatcggcta  1620
cggcctgga  cctggatga  gtacagctg  gctgtcatc  ctccagctc  ctgtgttgg  1680
tgtttcatc  tctctctcg  caagtatgt  cccctgacc  acaacaaag  ctaccggta  1740
cctgattgg  caatcgggc  gggctgggg  ctggccctt  cctccatgg  gtgtatccc  1800
ttggtcatt  tcatcctcc  ctgccggac  gagggaccg  tccgcgtga  aatcaaata  1860
ctgataacc  ccagggagc  caaccgctg  gctgtggag  gtgaagggg  tacgccctt  1920
cactccaga  caaccctca  gaacggtgc  ctcatgaaa  ccagtcacg  cattgtgga  1980
accatgatg  gaggtccgg  ctgtgtgac  ggcgccgct  tcctgccgt  tactaacct  2040
agattctcc  aggaccagg  ttacagagc  ttatatttg  actaggatt  tttttttaa  2100
tgtcacaga  aatgttact  tgtgtgtgt  tgtgtgtgt  tgtgtgtgt  tgtgtgtgt  2160
tgtgtttcg  gtgtgtctg  atatgtgta  tttgtttta  ttgggggat  attttgtac  2220
aaaagaaaa  ccatgggcc  atgtcctgg  gggagagga  ggactttca  attgatttt  2280
atgtatttt  tgggaactt  gtaaatttt  ctttgtatt  ttttaacat  taactatat  2340
tagagtctg  catacactt  gccacttga  ttggtcttg  cagcaacgg  tctcgtttt  2400
tgttttttg  ttttttttc  aaagcaatt  ttcggtgct  acatagctg  cagagagtt  2460
tgcccaaaa  caaatgaaa  aaaaaaaaa  2489



<210> 4154
<211> 621
<212> PRT
<213> Rattus norvegicus
<308> P31643
<400> 4154

Met Ala Thr Lys Glu Lys Leu Gln Cys Leu Lys Asp Phe His Lys Asp 
  1               5                  10                  15
Ile Leu Lys Pro Ser Pro Gly Lys Ser Pro Gly Thr Arg Pro Glu Asp 
             20                  25                  30
Glu Ala Asp Gly Lys Pro Pro Gln Arg Glu Lys Trp Ser Ser Lys Ile 
         35                  40                  45
Asp Phe Val Leu Ser Val Ala Gly Gly Phe Val Gly Leu Gly Asn Val 
     50                  55                  60
Trp Arg Phe Pro Tyr Leu Cys Tyr Lys Asn Gly Gly Gly Ala Phe Leu 
 65                  70                  75                  80
Ile Pro Tyr Phe Ile Phe Leu Phe Gly Ser Gly Leu Pro Val Phe Phe 
                 85                  90                  95
Leu Glu Val Ile Ile Gly Gln Tyr Thr Ser Glu Gly Gly Ile Thr Cys 
             100                105                110
Trp Glu Lys Ile Cys Pro Leu Phe Ser Gly Ile Gly Tyr Ala Ser Ile 
         115                120                125
Val Ile Val Ser Leu Leu Asn Val Tyr Tyr Ile Val Ile Leu Ala Trp 
     130                135                140
Ala Thr Tyr Tyr Leu Phe Gln Ser Phe Gln Lys Asp Leu Pro Trp Ala 
 145                150                155                160
His Cys Asn His Ser Trp Asn Thr Pro Gln Cys Met Glu Asp Thr Leu 
                 165                170                175
Arg Arg Asn Glu Ser His Trp Val Ser Leu Ser Ala Ala Asn Phe Thr 
             180                185                190
Ser Pro Val Ile Glu Phe Trp Glu Arg Asn Val Leu Ser Leu Ser Ser 
         195                200                205
Gly Ile Asp His Pro Gly Ser Leu Lys Trp Asp Leu Ala Leu Cys Leu 
     210                215                220
Leu Leu Val Trp Leu Val Cys Phe Phe Cys Ile Trp Lys Gly Val Arg 
 225                230                235                240
Ser Thr Gly Lys Val Val Tyr Phe Thr Ala Thr Phe Pro Phe Ala Met 
                 245                250                255
Leu Leu Val Leu Leu Val Arg Gly Leu Thr Leu Pro Gly Ala Gly Glu 
             260                265                270
Gly Ile Lys Phe Tyr Leu Tyr Pro Asn Ile Ser Arg Leu Glu Asp Pro 
         275                280                285
Gln Val Trp Ile Asp Ala Gly Thr Gln Ile Phe Phe Ser Tyr Ala Ile 
     290                295                300
Cys Leu Gly Ala Met Thr Ser Leu Gly Ser Tyr Asn Lys Tyr Lys Tyr 
 305                310                315                320
Asn Ser Tyr Arg Asp Cys Met Leu Leu Gly Cys Leu Asn Ser Gly Thr 
                 325                330                335
Ser Phe Val Ser Gly Phe Ala Ile Phe Ser Ile Leu Gly Phe Met Ala 
             340                345                350
Gln Glu Gln Gly Val Asp Ile Ala Asp Val Ala Glu Ser Gly Pro Gly 
         355                360                365
Leu Ala Phe Ile Ala Tyr Pro Lys Ala Val Thr Met Met Pro Leu Pro 
     370                375                380
Thr Phe Trp Ser Ile Leu Phe Phe Ile Met Leu Leu Leu Leu Gly Leu 
 385                390                395                400
Asp Ser Gln Phe Val Glu Val Glu Gly Gln Ile Thr Ser Leu Val Asp 
                 405                410                415
Leu Tyr Pro Ser Phe Leu Arg Lys Gly Tyr Arg Arg Glu Ile Phe Ile 
             420                425                430
Ala Ile Val Cys Ser Ile Ser Tyr Leu Leu Gly Leu Thr Met Val Thr 
         435                440                445
Glu Gly Gly Met Tyr Val Phe Gln Leu Phe Asp Tyr Tyr Ala Ala Ser 
     450                455                460
Gly Val Cys Leu Leu Trp Val Ala Phe Phe Glu Cys Phe Val Ile Ala 
 465                470                475                480
Trp Ile Tyr Gly Gly Asp Asn Leu Tyr Asp Gly Ile Glu Asp Met Ile 
                 485                490                495
Gly Tyr Arg Pro Gly Pro Trp Met Lys Tyr Ser Trp Ala Val Ile Thr 
             500                505                510
Pro Ala Leu Cys Val Gly Cys Phe Ile Phe Ser Leu Val Lys Tyr Val 
         515                520                525
Pro Leu Thr Tyr Asn Lys Val Tyr Arg Tyr Pro Asp Trp Ala Ile Gly 
     530                535                540
Leu Gly Trp Gly Leu Ala Leu Ser Ser Met Val Cys Ile Pro Leu Val 
 545                550                555                560
Ile Val Ile Leu Leu Cys Arg Thr Glu Gly Pro Leu Arg Val Arg Ile 
                 565                570                575
Lys Tyr Leu Ile Thr Pro Arg Glu Pro Asn Arg Trp Ala Val Glu Arg 
             580                585                590
Glu Gly Ala Thr Pro Phe His Ser Arg Ala Thr Leu Met Asn Gly Ala 
         595                600                605
Leu Met Lys Pro Ser His Val Ile Val Glu Thr Met Met 
     610                615                620



<210> 4155
<211> 3958
<212> DNA
<213> Homo sapiens
<308> XM_042939
<400> 4155

gaaagcaag  agatggcca  caaggagaa  ctgcagtgt  tgaaagatt  ccacaagga  60
atcctgaag  cctcaccag  gaagagccc  ggcacgcgg  ctgaggacg  ggctgaggg  120
aaacctccg  agagggaga  gtggtctag  aagatcgac  ttgtgctct  tgtggctgg  180
ggcttcgtg  gcttgggca  cgtctggcg  ttcccgtac  tctgctaca  gaatggtgg  240
ggtgcgttt  tcataccgt  ttttatttt  ctgtttggg  gcggcctgc  tgtgttttt  300
ttggagatc  tcataggcc  gtacacctc  gaagggggc  tcacctgct  ggaaaagat  360
tgccccttg  tctctggta  cggctatgc  tccgttgta  ttgtgtccc  cctgaatgt  420
tactacatc  tcatcctgg  ctgggccac  tactacctg  tccagtcct  ccagaagga  480
ctgccctgg  cacactgca  ccacagctg  aacacacct  actgcatgg  ggacaccat  540
cgcaagaac  agagtgtct  gatcaccat  agctccacc  acttcacct  ccctgtcat  600
gagttctgg  agcgcaacg  gctgagctt  tcccctgga  tcgaccacc  aggctctct  660
aaatgggac  tcgctctct  ccttctttt  gtctggcta  tgtgtttct  ctgcatctg  720
aagggcgtc  ggtccactg  gaaggtcgt  tacttcaca  ccacttttc  attcgccat  780
ctcctggtg  tgctggtcc  agggctgac  ctgccgggc  cgggcgcag  catcaagtt  840
tatctgtat  ctgacatca  ccgccttga  gacccacag  tgtggattg  cgctgggac  900
cagatattc  tctcttatg  catctgcct  ggggctatg  cctcgctgg  gagctacaa  960
aagtacaag  ataactcgt  cagggactg  atgctgctg  gatgcctga  cagtggtac  1020
agttttgtg  ctggcttcg  aattttttc  atcctgggc  tcatggcac  agagcaagg  1080
gtggacatt  ctgatgtgg  tgagtcagg  cctggcctg  ccttcattg  ctacccaaa  1140
gctgtgaca  tgatgccgc  gcccacatt  tggtccatt  tttttttta  tatgcttct  1200
ttgcttgga  tggatagcc  gtttgttga  gttgaagga  agatcacat  cttggttga  1260
ctttaccca  ccttcctaa  gaagggtta  cgtcgggaa  tcttcatcg  cttcgtgtg  1320
agcatcagc  acctgctgg  gctgacgat  gtgacggag  gtggcatgt  tgtgtttca  1380
ctctttgac  actatgcag  tagcggtgt  tgccttttg  gggttgcat  ctttgaatg  1440
tttgttatt  cctggatat  tggaggtga  aacctttat  atggtattg  ggacatgat  1500
ggctatcgg  ccgggccct  gatgaagta  agctgggct  tgatcactc  agttctctg  1560
gttggatgt  tcatcttct  gctcgtcaa  tacgtaccc  tgacctaca  caaaacata  1620
gtgtacccc  actgggcca  tgggctggg  tggagcctg  ccctttcct  catgctctg  1680
gttcccttg  tcatcgtca  ccgcctctg  cagactgag  ggccgttcc  tgtgagagt  1740
aagtacctg  tgaccccaa  ggaacccaa  cgctgggct  tggagcgcg  gggagccac  1800
ccttacaac  ctcgcaccg  catgaacgg  gctctcgtg  aaccgaccc  catcattgt  1860
gagaccatg  tgtgagctc  ctcgggtcg  cggggccgg  ggctttcct  ctgtttact  1920
acattagat  ctcatagga  caggtttac  gagctttat  tttgcacta  gattttttt  1980
tttttgtaa  tgtcacaga  aatgtaatt  tgggtatgt  tgcgtgcgt  tgtgtgtgt  2040
tgtgtatcg  gtgtgtgtg  tttgttttg  tttggggga  attttgtac  aaaagaaaa  2100
ccacgggaa  atgtccgtg  agaggcaga  ctttcatac  gaattagat  tattttatg  2160
gaatttggt  aatttttct  tgtattttt  tttttacat  taagtatat  tacacttag  2220
gattgtcat  tacttttac  acttgaatt  atcttcttg  cagcaatag  tctcatttt  2280
aaaagcaat  cttcggtgc  gtgtagctg  cagaaagtt  tgtccagta  acgcaggat  2340
gaattttcc  gggactcta  acccatctt  aggtggtat  ccttccaaa  cctggttca  2400
atggaagaa  tagcaggag  gaggaccca  tagctggca  acccagggg  aagaaagga  2460
ggctgtgag  agatacctc  ttaaacttg  cttagtgaa  aagagagat  ccaaaggaa  2520
gaaccaacc  ttcacataa  ggagactgg  tgaagctga  tgaggaggc  ctatagcag  2580
agtctgatt  taagagcag  agaaacttg  accagaagc  aaatcccac  tttaatttt  2640
agatggtga  tggatagtc  gtagaccgt  agaaccact  gccagagag  gagctgcta  2700
agatccaag  aggctggca  gagtgaggc  cacaactca  cctcgcaag  ggtggcaga  2760
gcacaggag  ccacagtcc  tcctggggc  ttccaggca  agaaggagc  gaggctctc  2820
cggcaggag  tggggtctc  gggctcaga  gagtctgtt  catttgaat  gggtcatag  2880
aggttctgg  cattcccca  gcaacatct  agcatctct  aaagttgcc  gcaggaatg  2940
agcatgaca  acctgttga  ggactaggg  agtggtggg  aggtgagtg  accaaagga  3000
ataggcccc  ggcatgcag  tgggcccgg  gtcggggag  ggtgctttc  ttcctcatc  3060
ccccactcc  cactctcag  ctgggagac  cctgccaag  cctcattaa  gatgccacc  3120
tgggctgcc  tggcaccta  caaggcaca  caagaacag  ttttgagtc  gtatcctcc  3180
ctgggggaa  tgctcccag  tcagaacaa  ggcagcccg  ggtgctgac  taggatata  3240
caaagctct  cacttcaaa  cccctgcaa  agctgggtt  acagacatt  accacctgc  3300
gacccaaaa  agaaggcct  ggagagttt  ctagaaggt  gggattgtc  gggtcctgg  3360
ccctcagaa  tggcttgat  aagggcctt  tgtggagca  aggttgtct  tgaaccagg  3420
gagaaggta  tataccttt  aaatcccca  ggcagacac  cccccaccc  gcccctatt  3480
ggacctaaa  tgtgccatt  gaacagtca  ttccaagct  agtctaaat  aaaccgaaa  3540
gtgaccacg  acaaaggca  tcactgcct  gaggggtgc  gaccgcaga  ttttcacag  3600
aggggctct  ggaaccctg  aaaccccct  cttaaattt  ggaggagga  tatgccttt  3660
gtgtccccc  cccaagggg  aattctgaa  cccatcttt  gcaggcata  atatttcac  3720
gtttccaaa  ctatctact  tgccaaaca  cacccagtc  tattccaaa  tctcaacga  3780
tctatcttg  tcctgtttt  ctatgtatt  atggttgcc  tttgtgtct  atttgattt  3840
actgttttt  ccctgattt  atggagtag  attgtgacc  gttttcctt  gtcttatat  3900
actttagta  actaaccac  gtcaatgat  gagggcagg  ggcacgtgg  gaagaggg  3958



<210> 4156
<211> 620
<212> PRT
<213> Homo sapiens
<308> XP_042939
<400> 4156

Met Ala Thr Lys Glu Lys Leu Gln Cys Leu Lys Asp Phe His Lys Asp 
  1               5                  10                  15
Ile Leu Lys Pro Ser Pro Gly Lys Ser Pro Gly Thr Arg Pro Glu Asp 
             20                  25                  30
Glu Ala Glu Gly Lys Pro Pro Gln Arg Glu Lys Trp Ser Ser Lys Ile 
         35                  40                  45
Asp Phe Val Leu Ser Val Ala Gly Gly Phe Val Gly Leu Gly Asn Val 
     50                  55                  60
Trp Arg Phe Pro Tyr Leu Cys Tyr Lys Asn Gly Gly Gly Ala Phe Leu 
 65                  70                  75                  80
Ile Pro Tyr Phe Ile Phe Leu Phe Gly Ser Gly Leu Pro Val Phe Phe 
                 85                  90                  95
Leu Glu Ile Ile Ile Gly Gln Tyr Thr Ser Glu Gly Gly Ile Thr Cys 
             100                105                110
Trp Glu Lys Ile Cys Pro Leu Phe Ser Gly Ile Gly Tyr Ala Ser Val 
         115                120                125
Val Ile Val Ser Leu Leu Asn Val Tyr Tyr Ile Val Ile Leu Ala Trp 
     130                135                140
Ala Thr Tyr Tyr Leu Phe Gln Ser Phe Gln Lys Glu Leu Pro Trp Ala 
 145                150                155                160
His Cys Asn His Ser Trp Asn Thr Pro His Cys Met Glu Asp Thr Met 
                 165                170                175
Arg Lys Asn Lys Ser Val Trp Ile Thr Ile Ser Ser Thr Asn Phe Thr 
             180                185                190
Ser Pro Val Ile Glu Phe Trp Glu Arg Asn Val Leu Ser Leu Ser Pro 
         195                200                205
Gly Ile Asp His Pro Gly Ser Leu Lys Trp Asp Leu Ala Leu Cys Leu 
     210                215                220
Leu Leu Val Trp Leu Val Cys Phe Phe Cys Ile Trp Lys Gly Val Arg 
 225                230                235                240
Ser Thr Gly Lys Val Val Tyr Phe Thr Ala Thr Phe Pro Phe Ala Met 
                 245                250                255
Leu Leu Val Leu Leu Val Arg Gly Leu Thr Leu Pro Gly Ala Gly Ala 
             260                265                270
Gly Ile Lys Phe Tyr Leu Tyr Pro Asp Ile Thr Arg Leu Glu Asp Pro 
         275                280                285
Gln Val Trp Ile Asp Ala Gly Thr Gln Ile Phe Phe Ser Tyr Ala Ile 
     290                295                300
Cys Leu Gly Ala Met Thr Ser Leu Gly Ser Tyr Asn Lys Tyr Lys Tyr 
 305                310                315                320
Asn Ser Tyr Arg Asp Cys Met Leu Leu Gly Cys Leu Asn Ser Gly Thr 
                 325                330                335
Ser Phe Val Ser Gly Phe Ala Ile Phe Ser Ile Leu Gly Phe Met Ala 
             340                345                350
Gln Glu Gln Gly Val Asp Ile Ala Asp Val Ala Glu Ser Gly Pro Gly 
         355                360                365
Leu Ala Phe Ile Ala Tyr Pro Lys Ala Val Thr Met Met Pro Leu Pro 
     370                375                380
Thr Phe Trp Ser Ile Leu Phe Phe Ile Met Leu Leu Leu Leu Gly Leu 
 385                390                395                400
Asp Ser Gln Phe Val Glu Val Glu Gly Gln Ile Thr Ser Leu Val Asp 
                 405                410                415
Leu Tyr Pro Ser Phe Leu Arg Lys Gly Tyr Arg Arg Glu Ile Phe Ile 
             420                425                430
Ala Phe Val Cys Ser Ile Ser Tyr Leu Leu Gly Leu Thr Met Val Thr 
         435                440                445
Glu Gly Gly Met Tyr Val Phe Gln Leu Phe Asp Tyr Tyr Ala Ala Ser 
     450                455                460
Gly Val Cys Leu Leu Trp Val Ala Phe Phe Glu Cys Phe Val Ile Ala 
 465                470                475                480
Trp Ile Tyr Gly Gly Asp Asn Leu Tyr Asp Gly Ile Glu Asp Met Ile 
                 485                490                495
Gly Tyr Arg Pro Gly Pro Trp Met Lys Tyr Ser Trp Ala Val Ile Thr 
             500                505                510
Pro Val Leu Cys Val Gly Cys Phe Ile Phe Ser Leu Val Lys Tyr Val 
         515                520                525
Pro Leu Thr Tyr Asn Lys Thr Tyr Val Tyr Pro Asn Trp Ala Ile Gly 
     530                535                540
Leu Gly Trp Ser Leu Ala Leu Ser Ser Met Leu Cys Val Pro Leu Val 
 545                550                555                560
Ile Val Ile Arg Leu Cys Gln Thr Glu Gly Pro Phe Leu Val Arg Val 
                 565                570                575
Lys Tyr Leu Leu Thr Pro Arg Glu Pro Asn Arg Trp Ala Val Glu Arg 
             580                585                590
Glu Gly Ala Thr Pro Tyr Asn Ser Arg Thr Val Met Asn Gly Ala Leu 
         595                600                605
Val Lys Pro Thr His Ile Ile Val Glu Thr Met Met 
     610                615                620



<210> 4157
<211> 609
<212> DNA
<213> Rattus norvegicus
<308> M96626
<400> 4157

gaattcaga  tgtcattgt  caatttgga  ggaagccct  cagctgttc  ccactgtcc  60
cagaacagt  gctctggtg  ctttttgtt  gtgttgggg  gctggtctg  ggacaggtc  120
ttgccacta  ccccaccag  cagctcaag  gcctgaagg  agcagggca  gggcctggg  180
aggatgaga  gactgatga  gagttggcg  aaggggaag  agaaattga  catgctgag  240
gagagctcc  cagaggcca  atcctctgg  ttcggggcc  caaccggat  cagacacag  300
tgtgttggg  cggaaaaaa  atgttgaga  ctaccgaag  aggataagg  agtattgcc  360
aacacagat  gaggtagtg  gtaccttca  gagaagcgg  tcatttcag  gtgctgtgc  420
ccggcggtc  tcggtcctc  gccagctcc  tgacgtaac  aatctttct  cccctactc  480
cgtaactct  tctgccgcc  agcccacca  cgctgctgg  agtgagtct  gacttccct  540
ttctctcat  aatggcacc  gggggaaga  aaagcctcc  cgactctgc  ttctctttt  600
cagtcttgc  609



<210> 4158
<211> 1258
<212> PRT
<213> Rattus norvegicus
<308> Q64568
<400> 4158

Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln 
  1               5                  10                  15
Gln Gln Arg Glu Val Pro His Val Gly Gly Phe Gly Cys Thr Leu Ala 
             20                  25                  30
Glu Leu Arg Ser Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys 
         35                  40                  45
Ile Gln Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys 
     50                  55                  60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys 
 65                  70                  75                  80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys 
                 85                  90                  95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
             100                105                110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala 
         115                120                125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala 
     130                135                140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile 
 145                150                155                160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp 
                 165                170                175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu 
             180                185                190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val 
         195                200                205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu 
     210                215                220
Leu Pro Ala Asp Gly Val Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp 
 225                230                235                240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp 
                 245                250                255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly 
             260                265                270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile 
         275                280                285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys 
     290                295                300
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala 
 305                310                315                320
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser 
                 325                330                335
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Val 
             340                345                350
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala 
         355                360                365
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile 
     370                375                380
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Asp Gly Arg 
 385                390                395                400
Val Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys 
                 405                410                415
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly 
             420                425                430
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met 
         435                440                445
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met 
     450                455                460
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr 
 465                470                475                480
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys 
                 485                490                495
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu 
             500                505                510
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro 
         515                520                525
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu 
     530                535                540
Cys Ala Leu Leu Gly Phe Ile Leu Asp Leu Lys Arg Asp Phe Gln Pro 
 545                550                555                560
Val Arg Glu Gln Ile Pro Glu Asp Gln Leu Tyr Lys Val Tyr Thr Phe 
                 565                570                575
Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Met Pro Asp Gly 
             580                585                590
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys 
         595                600                605
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro 
     610                615                620
Arg Asp Arg Asp Asp Met Val Lys Lys Ile Ile Glu Pro Met Ala Cys 
 625                630                635                640
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Ser Ala Ile 
                 645                650                655
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr 
             660                665                670
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro 
         675                680                685
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val 
     690                695                700
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly 
 705                710                715                720
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe 
                 725                730                735
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu 
             740                745                750
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr 
         755                760                765
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu 
     770                775                780
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro 
 785                790                795                800
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr 
                 805                810                815
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe 
             820                825                830
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser 
         835                840                845
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val 
     850                855                860
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys 
 865                870                875                880
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser 
                 885                890                895
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys 
             900                905                910
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn 
         915                920                925
Ile Leu Gly His Ala Val Tyr Gln Leu Thr Ile Ile Phe Thr Leu Leu 
     930                935                940
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro 
 945                950                955                960
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe 
                 965                970                975
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly 
             980                985                990
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr 
         995                1000                1005
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly 
     1010                1015                1020
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp 
 1025                1030                1035                1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala 
                 1045                1050                1055
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly 
             1060                1065                1070
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu 
         1075                1080                1085
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp 
     1090                1095                1100
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Glu Val Val Ser Thr 
 1105                1110                1115                1120
Phe Lys Arg Ser Gly Ser Phe Gln Gly Ala Val Arg Arg Arg Ser Ser 
                 1125                1130                1135
Val Leu Ser Gln Leu His Asp Val Thr Asn Leu Ser Thr Pro Thr His 
             1140                1145                1150
Ile Arg Val Val Lys Ala Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu 
         1155                1160                1165
Lys Pro Glu Ser Lys Ser Cys Ile His Asn Phe Met Ala Thr Pro Glu 
     1170                1175                1180
Phe Leu Ile Asn Asp Tyr Thr His Asn Ile Pro Leu Ile Asp Asp Thr 
 1185                1190                1195                1200
Asp Val Asp Glu Asn Glu Glu Arg Leu Arg Ala Pro Pro Pro Pro Pro 
                 1205                1210                1215
Pro Asn Gln Asn Asn Asn Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr 
             1220                1225                1230
His Ala Thr Lys Ser Ala Thr Ser Ser Ala Phe Ser Ser Arg Pro Gly 
         1235                1240                1245
Ser Pro Leu His Ser Met Glu Thr Ser Leu 
     1250                1255



<210> 4159
<211> 257
<212> DNA
<213> Homo sapiens
<308> U15689
<400> 4159

cagacgcag  tgtgttggg  cggaaaaaa  atgttgaga  ctaccgaag  aggataagg  60
agtattgcc  aacacagat  gaggtagtg  gtaccttca  gagaagcgg  tcagttcag  120
gtgctgtgc  ccggcggtc  tcggtcctc  gccagcttc  tgacgtaac  aatctttct  180
cccctactc  cgcaattct  tctgctgcc  atcctacca  tgctgctgg  aatccgggt  240
gtgaaagcg  tccgtag  257



<210> 4160
<211> 1220
<212> PRT
<213> Homo sapiens
<308> Q16720
<400> 4160

Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln 
  1               5                  10                  15
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala 
             20                  25                  30
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys 
         35                  40                  45
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys 
     50                  55                  60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys 
 65                  70                  75                  80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys 
                 85                  90                  95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
             100                105                110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala 
         115                120                125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala 
     130                135                140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile 
 145                150                155                160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp 
                 165                170                175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu 
             180                185                190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val 
         195                200                205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu 
     210                215                220
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp 
 225                230                235                240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp 
                 245                250                255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly 
             260                265                270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile 
         275                280                285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys 
     290                295                300
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala 
 305                310                315                320
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser 
                 325                330                335
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala 
             340                345                350
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala 
         355                360                365
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile 
     370                375                380
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg 
 385                390                395                400
Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys 
                 405                410                415
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly 
             420                425                430
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met 
         435                440                445
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met 
     450                455                460
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr 
 465                470                475                480
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys 
                 485                490                495
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu 
             500                505                510
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro 
         515                520                525
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu 
     530                535                540
Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro 
 545                550                555                560
Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe 
                 565                570                575
Asn Ser Val Arg Lys Ser Met Ser Thr Val Val Arg Met Pro Asp Gly 
             580                585                590
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys 
         595                600                605
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro 
     610                615                620
Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys 
 625                630                635                640
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Tyr Ala Gly 
                 645                650                655
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr 
             660                665                670
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro 
         675                680                685
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val 
     690                695                700
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly 
 705                710                715                720
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe 
                 725                730                735
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu 
             740                745                750
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr 
         755                760                765
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu 
     770                775                780
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro 
 785                790                795                800
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr 
                 805                810                815
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe 
             820                825                830
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser 
         835                840                845
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val 
     850                855                860
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys 
 865                870                875                880
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser 
                 885                890                895
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys 
             900                905                910
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn 
         915                920                925
Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu 
     930                935                940
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro 
 945                950                955                960
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe 
                 965                970                975
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly 
             980                985                990
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr 
         995                1000                1005
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly 
     1010                1015                1020
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp 
 1025                1030                1035                1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala 
                 1045                1050                1055
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly 
             1060                1065                1070
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu 
         1075                1080                1085
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp 
     1090                1095                1100
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile Arg Val Val Lys Ala 
 1105                1110                1115                1120
Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser Lys Thr 
                 1125                1130                1135
Ser Ile His Asn Phe Met Ala Thr Pro Glu Phe Leu Ile Asn Asp Tyr 
             1140                1145                1150
Thr His Asn Ile Pro Leu Ile Asp Asp Thr Asp Val Asp Glu Asn Glu 
         1155                1160                1165
Glu Arg Leu Arg Ala Pro Pro Pro Pro Ser Pro Asn Gln Asn Asn Asn 
     1170                1175                1180
Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr His Val Thr Lys Ser Ala 
 1185                1190                1195                1200
Thr Ser Ser Val Phe Ser Ser Ser Pro Gly Ser Pro Leu His Ser Val 
                 1205                1210                1215
Glu Thr Ser Leu 
             1220



<210> 4161
<211> 609
<212> DNA
<213> Rattus norvegicus
<308> M96626
<400> 4161

gaattcaga  tgtcattgt  caatttgga  ggaagccct  cagctgttc  ccactgtcc  60
cagaacagt  gctctggtg  ctttttgtt  gtgttgggg  gctggtctg  ggacaggtc  120
ttgccacta  ccccaccag  cagctcaag  gcctgaagg  agcagggca  gggcctggg  180
aggatgaga  gactgatga  gagttggcg  aaggggaag  agaaattga  catgctgag  240
gagagctcc  cagaggcca  atcctctgg  ttcggggcc  caaccggat  cagacacag  300
tgtgttggg  cggaaaaaa  atgttgaga  ctaccgaag  aggataagg  agtattgcc  360
aacacagat  gaggtagtg  gtaccttca  gagaagcgg  tcatttcag  gtgctgtgc  420
ccggcggtc  tcggtcctc  gccagctcc  tgacgtaac  aatctttct  cccctactc  480
cgtaactct  tctgccgcc  agcccacca  cgctgctgg  agtgagtct  gacttccct  540
ttctctcat  aatggcacc  gggggaaga  aaagcctcc  cgactctgc  ttctctttt  600
cagtcttgc  609



<210> 4162
<211> 1258
<212> PRT
<213> Rattus norvegicus
<308> Q64568
<400> 4162

Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln 
  1               5                  10                  15
Gln Gln Arg Glu Val Pro His Val Gly Gly Phe Gly Cys Thr Leu Ala 
             20                  25                  30
Glu Leu Arg Ser Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys 
         35                  40                  45
Ile Gln Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys 
     50                  55                  60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys 
 65                  70                  75                  80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys 
                 85                  90                  95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
             100                105                110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala 
         115                120                125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala 
     130                135                140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile 
 145                150                155                160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp 
                 165                170                175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu 
             180                185                190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val 
         195                200                205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu 
     210                215                220
Leu Pro Ala Asp Gly Val Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp 
 225                230                235                240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp 
                 245                250                255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly 
             260                265                270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile 
         275                280                285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys 
     290                295                300
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala 
 305                310                315                320
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser 
                 325                330                335
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Val 
             340                345                350
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala 
         355                360                365
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile 
     370                375                380
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Asp Gly Arg 
 385                390                395                400
Val Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys 
                 405                410                415
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly 
             420                425                430
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met 
         435                440                445
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met 
     450                455                460
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr 
 465                470                475                480
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys 
                 485                490                495
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu 
             500                505                510
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro 
         515                520                525
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu 
     530                535                540
Cys Ala Leu Leu Gly Phe Ile Leu Asp Leu Lys Arg Asp Phe Gln Pro 
 545                550                555                560
Val Arg Glu Gln Ile Pro Glu Asp Gln Leu Tyr Lys Val Tyr Thr Phe 
                 565                570                575
Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Met Pro Asp Gly 
             580                585                590
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys 
         595                600                605
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro 
     610                615                620
Arg Asp Arg Asp Asp Met Val Lys Lys Ile Ile Glu Pro Met Ala Cys 
 625                630                635                640
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Ser Ala Ile 
                 645                650                655
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr 
             660                665                670
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro 
         675                680                685
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val 
     690                695                700
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly 
 705                710                715                720
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe 
                 725                730                735
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu 
             740                745                750
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr 
         755                760                765
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu 
     770                775                780
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro 
 785                790                795                800
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr 
                 805                810                815
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe 
             820                825                830
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser 
         835                840                845
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val 
     850                855                860
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys 
 865                870                875                880
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser 
                 885                890                895
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys 
             900                905                910
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn 
         915                920                925
Ile Leu Gly His Ala Val Tyr Gln Leu Thr Ile Ile Phe Thr Leu Leu 
     930                935                940
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro 
 945                950                955                960
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe 
                 965                970                975
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly 
             980                985                990
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr 
         995                1000                1005
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly 
     1010                1015                1020
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp 
 1025                1030                1035                1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala 
                 1045                1050                1055
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly 
             1060                1065                1070
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu 
         1075                1080                1085
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp 
     1090                1095                1100
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Glu Val Val Ser Thr 
 1105                1110                1115                1120
Phe Lys Arg Ser Gly Ser Phe Gln Gly Ala Val Arg Arg Arg Ser Ser 
                 1125                1130                1135
Val Leu Ser Gln Leu His Asp Val Thr Asn Leu Ser Thr Pro Thr His 
             1140                1145                1150
Ile Arg Val Val Lys Ala Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu 
         1155                1160                1165
Lys Pro Glu Ser Lys Ser Cys Ile His Asn Phe Met Ala Thr Pro Glu 
     1170                1175                1180
Phe Leu Ile Asn Asp Tyr Thr His Asn Ile Pro Leu Ile Asp Asp Thr 
 1185                1190                1195                1200
Asp Val Asp Glu Asn Glu Glu Arg Leu Arg Ala Pro Pro Pro Pro Pro 
                 1205                1210                1215
Pro Asn Gln Asn Asn Asn Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr 
             1220                1225                1230
His Ala Thr Lys Ser Ala Thr Ser Ser Ala Phe Ser Ser Arg Pro Gly 
         1235                1240                1245
Ser Pro Leu His Ser Met Glu Thr Ser Leu 
     1250                1255



<210> 4163
<211> 257
<212> DNA
<213> Homo sapiens
<308> U15689
<400> 4163

cagacgcag  tgtgttggg  cggaaaaaa  atgttgaga  ctaccgaag  aggataagg  60
agtattgcc  aacacagat  gaggtagtg  gtaccttca  gagaagcgg  tcagttcag  120
gtgctgtgc  ccggcggtc  tcggtcctc  gccagcttc  tgacgtaac  aatctttct  180
cccctactc  cgcaattct  tctgctgcc  atcctacca  tgctgctgg  aatccgggt  240
gtgaaagcg  tccgtag  257



<210> 4164
<211> 1220
<212> PRT
<213> Homo sapiens
<308> Q16720
<400> 4164

Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln 
  1               5                  10                  15
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala 
             20                  25                  30
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys 
         35                  40                  45
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys 
     50                  55                  60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys 
 65                  70                  75                  80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys 
                 85                  90                  95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
             100                105                110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala 
         115                120                125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala 
     130                135                140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile 
 145                150                155                160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp 
                 165                170                175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu 
             180                185                190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val 
         195                200                205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu 
     210                215                220
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp 
 225                230                235                240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp 
                 245                250                255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly 
             260                265                270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile 
         275                280                285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys 
     290                295                300
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala 
 305                310                315                320
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser 
                 325                330                335
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala 
             340                345                350
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala 
         355                360                365
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile 
     370                375                380
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg 
 385                390                395                400
Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys 
                 405                410                415
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly 
             420                425                430
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met 
         435                440                445
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met 
     450                455                460
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr 
 465                470                475                480
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys 
                 485                490                495
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu 
             500                505                510
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro 
         515                520                525
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu 
     530                535                540
Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro 
 545                550                555                560
Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe 
                 565                570                575
Asn Ser Val Arg Lys Ser Met Ser Thr Val Val Arg Met Pro Asp Gly 
             580                585                590
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys 
         595                600                605
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro 
     610                615                620
Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys 
 625                630                635                640
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Tyr Ala Gly 
                 645                650                655
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr 
             660                665                670
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro 
         675                680                685
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val 
     690                695                700
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly 
 705                710                715                720
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe 
                 725                730                735
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu 
             740                745                750
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr 
         755                760                765
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu 
     770                775                780
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro 
 785                790                795                800
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr 
                 805                810                815
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe 
             820                825                830
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser 
         835                840                845
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val 
     850                855                860
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys 
 865                870                875                880
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser 
                 885                890                895
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys 
             900                905                910
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn 
         915                920                925
Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu 
     930                935                940
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro 
 945                950                955                960
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe 
                 965                970                975
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly 
             980                985                990
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr 
         995                1000                1005
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly 
     1010                1015                1020
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp 
 1025                1030                1035                1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala 
                 1045                1050                1055
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly 
             1060                1065                1070
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu 
         1075                1080                1085
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp 
     1090                1095                1100
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile Arg Val Val Lys Ala 
 1105                1110                1115                1120
Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser Lys Thr 
                 1125                1130                1135
Ser Ile His Asn Phe Met Ala Thr Pro Glu Phe Leu Ile Asn Asp Tyr 
             1140                1145                1150
Thr His Asn Ile Pro Leu Ile Asp Asp Thr Asp Val Asp Glu Asn Glu 
         1155                1160                1165
Glu Arg Leu Arg Ala Pro Pro Pro Pro Ser Pro Asn Gln Asn Asn Asn 
     1170                1175                1180
Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr His Val Thr Lys Ser Ala 
 1185                1190                1195                1200
Thr Ser Ser Val Phe Ser Ser Ser Pro Gly Ser Pro Leu His Ser Val 
                 1205                1210                1215
Glu Thr Ser Leu 
             1220



<210> 4165
<211> 609
<212> DNA
<213> Rattus norvegicus
<308> M96626
<400> 4165

gaattcaga  tgtcattgt  caatttgga  ggaagccct  cagctgttc  ccactgtcc  60
cagaacagt  gctctggtg  ctttttgtt  gtgttgggg  gctggtctg  ggacaggtc  120
ttgccacta  ccccaccag  cagctcaag  gcctgaagg  agcagggca  gggcctggg  180
aggatgaga  gactgatga  gagttggcg  aaggggaag  agaaattga  catgctgag  240
gagagctcc  cagaggcca  atcctctgg  ttcggggcc  caaccggat  cagacacag  300
tgtgttggg  cggaaaaaa  atgttgaga  ctaccgaag  aggataagg  agtattgcc  360
aacacagat  gaggtagtg  gtaccttca  gagaagcgg  tcatttcag  gtgctgtgc  420
ccggcggtc  tcggtcctc  gccagctcc  tgacgtaac  aatctttct  cccctactc  480
cgtaactct  tctgccgcc  agcccacca  cgctgctgg  agtgagtct  gacttccct  540
ttctctcat  aatggcacc  gggggaaga  aaagcctcc  cgactctgc  ttctctttt  600
cagtcttgc  609



<210> 4166
<211> 1258
<212> PRT
<213> Rattus norvegicus
<308> Q64568
<400> 4166

Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln 
  1               5                  10                  15
Gln Gln Arg Glu Val Pro His Val Gly Gly Phe Gly Cys Thr Leu Ala 
             20                  25                  30
Glu Leu Arg Ser Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys 
         35                  40                  45
Ile Gln Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys 
     50                  55                  60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys 
 65                  70                  75                  80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys 
                 85                  90                  95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
             100                105                110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala 
         115                120                125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala 
     130                135                140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile 
 145                150                155                160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp 
                 165                170                175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu 
             180                185                190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val 
         195                200                205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu 
     210                215                220
Leu Pro Ala Asp Gly Val Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp 
 225                230                235                240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp 
                 245                250                255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly 
             260                265                270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile 
         275                280                285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys 
     290                295                300
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala 
 305                310                315                320
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser 
                 325                330                335
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Val 
             340                345                350
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala 
         355                360                365
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile 
     370                375                380
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Asp Gly Arg 
 385                390                395                400
Val Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys 
                 405                410                415
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly 
             420                425                430
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met 
         435                440                445
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met 
     450                455                460
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr 
 465                470                475                480
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys 
                 485                490                495
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu 
             500                505                510
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro 
         515                520                525
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu 
     530                535                540
Cys Ala Leu Leu Gly Phe Ile Leu Asp Leu Lys Arg Asp Phe Gln Pro 
 545                550                555                560
Val Arg Glu Gln Ile Pro Glu Asp Gln Leu Tyr Lys Val Tyr Thr Phe 
                 565                570                575
Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Met Pro Asp Gly 
             580                585                590
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys 
         595                600                605
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro 
     610                615                620
Arg Asp Arg Asp Asp Met Val Lys Lys Ile Ile Glu Pro Met Ala Cys 
 625                630                635                640
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Ser Ala Ile 
                 645                650                655
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr 
             660                665                670
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro 
         675                680                685
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val 
     690                695                700
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly 
 705                710                715                720
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe 
                 725                730                735
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu 
             740                745                750
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr 
         755                760                765
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu 
     770                775                780
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro 
 785                790                795                800
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr 
                 805                810                815
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe 
             820                825                830
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser 
         835                840                845
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val 
     850                855                860
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys 
 865                870                875                880
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser 
                 885                890                895
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys 
             900                905                910
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn 
         915                920                925
Ile Leu Gly His Ala Val Tyr Gln Leu Thr Ile Ile Phe Thr Leu Leu 
     930                935                940
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro 
 945                950                955                960
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe 
                 965                970                975
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly 
             980                985                990
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr 
         995                1000                1005
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly 
     1010                1015                1020
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp 
 1025                1030                1035                1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala 
                 1045                1050                1055
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly 
             1060                1065                1070
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu 
         1075                1080                1085
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp 
     1090                1095                1100
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Glu Val Val Ser Thr 
 1105                1110                1115                1120
Phe Lys Arg Ser Gly Ser Phe Gln Gly Ala Val Arg Arg Arg Ser Ser 
                 1125                1130                1135
Val Leu Ser Gln Leu His Asp Val Thr Asn Leu Ser Thr Pro Thr His 
             1140                1145                1150
Ile Arg Val Val Lys Ala Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu 
         1155                1160                1165
Lys Pro Glu Ser Lys Ser Cys Ile His Asn Phe Met Ala Thr Pro Glu 
     1170                1175                1180
Phe Leu Ile Asn Asp Tyr Thr His Asn Ile Pro Leu Ile Asp Asp Thr 
 1185                1190                1195                1200
Asp Val Asp Glu Asn Glu Glu Arg Leu Arg Ala Pro Pro Pro Pro Pro 
                 1205                1210                1215
Pro Asn Gln Asn Asn Asn Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr 
             1220                1225                1230
His Ala Thr Lys Ser Ala Thr Ser Ser Ala Phe Ser Ser Arg Pro Gly 
         1235                1240                1245
Ser Pro Leu His Ser Met Glu Thr Ser Leu 
     1250                1255



<210> 4167
<211> 257
<212> DNA
<213> Homo sapiens
<308> U15689
<400> 4167

cagacgcag  tgtgttggg  cggaaaaaa  atgttgaga  ctaccgaag  aggataagg  60
agtattgcc  aacacagat  gaggtagtg  gtaccttca  gagaagcgg  tcagttcag  120
gtgctgtgc  ccggcggtc  tcggtcctc  gccagcttc  tgacgtaac  aatctttct  180
cccctactc  cgcaattct  tctgctgcc  atcctacca  tgctgctgg  aatccgggt  240
gtgaaagcg  tccgtag  257



<210> 4168
<211> 1220
<212> PRT
<213> Homo sapiens
<308> Q16720
<400> 4168

Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln 
  1               5                  10                  15
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala 
             20                  25                  30
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys 
         35                  40                  45
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys 
     50                  55                  60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys 
 65                  70                  75                  80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys 
                 85                  90                  95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
             100                105                110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala 
         115                120                125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala 
     130                135                140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile 
 145                150                155                160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp 
                 165                170                175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu 
             180                185                190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val 
         195                200                205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu 
     210                215                220
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp 
 225                230                235                240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp 
                 245                250                255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly 
             260                265                270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile 
         275                280                285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys 
     290                295                300
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala 
 305                310                315                320
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser 
                 325                330                335
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala 
             340                345                350
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala 
         355                360                365
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile 
     370                375                380
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg 
 385                390                395                400
Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys 
                 405                410                415
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly 
             420                425                430
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met 
         435                440                445
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met 
     450                455                460
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr 
 465                470                475                480
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys 
                 485                490                495
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu 
             500                505                510
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro 
         515                520                525
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu 
     530                535                540
Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro 
 545                550                555                560
Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe 
                 565                570                575
Asn Ser Val Arg Lys Ser Met Ser Thr Val Val Arg Met Pro Asp Gly 
             580                585                590
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys 
         595                600                605
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro 
     610                615                620
Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys 
 625                630                635                640
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Tyr Ala Gly 
                 645                650                655
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr 
             660                665                670
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro 
         675                680                685
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val 
     690                695                700
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly 
 705                710                715                720
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe 
                 725                730                735
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu 
             740                745                750
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr 
         755                760                765
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu 
     770                775                780
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro 
 785                790                795                800
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr 
                 805                810                815
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe 
             820                825                830
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser 
         835                840                845
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val 
     850                855                860
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys 
 865                870                875                880
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser 
                 885                890                895
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys 
             900                905                910
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn 
         915                920                925
Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu 
     930                935                940
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro 
 945                950                955                960
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe 
                 965                970                975
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly 
             980                985                990
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr 
         995                1000                1005
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly 
     1010                1015                1020
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp 
 1025                1030                1035                1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala 
                 1045                1050                1055
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly 
             1060                1065                1070
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu 
         1075                1080                1085
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp 
     1090                1095                1100
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile Arg Val Val Lys Ala 
 1105                1110                1115                1120
Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser Lys Thr 
                 1125                1130                1135
Ser Ile His Asn Phe Met Ala Thr Pro Glu Phe Leu Ile Asn Asp Tyr 
             1140                1145                1150
Thr His Asn Ile Pro Leu Ile Asp Asp Thr Asp Val Asp Glu Asn Glu 
         1155                1160                1165
Glu Arg Leu Arg Ala Pro Pro Pro Pro Ser Pro Asn Gln Asn Asn Asn 
     1170                1175                1180
Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr His Val Thr Lys Ser Ala 
 1185                1190                1195                1200
Thr Ser Ser Val Phe Ser Ser Ser Pro Gly Ser Pro Leu His Ser Val 
                 1205                1210                1215
Glu Thr Ser Leu 
             1220



<210> 4169
<211> 609
<212> DNA
<213> Rattus norvegicus
<308> M96626
<400> 4169

gaattcaga  tgtcattgt  caatttgga  ggaagccct  cagctgttc  ccactgtcc  60
cagaacagt  gctctggtg  ctttttgtt  gtgttgggg  gctggtctg  ggacaggtc  120
ttgccacta  ccccaccag  cagctcaag  gcctgaagg  agcagggca  gggcctggg  180
aggatgaga  gactgatga  gagttggcg  aaggggaag  agaaattga  catgctgag  240
gagagctcc  cagaggcca  atcctctgg  ttcggggcc  caaccggat  cagacacag  300
tgtgttggg  cggaaaaaa  atgttgaga  ctaccgaag  aggataagg  agtattgcc  360
aacacagat  gaggtagtg  gtaccttca  gagaagcgg  tcatttcag  gtgctgtgc  420
ccggcggtc  tcggtcctc  gccagctcc  tgacgtaac  aatctttct  cccctactc  480
cgtaactct  tctgccgcc  agcccacca  cgctgctgg  agtgagtct  gacttccct  540
ttctctcat  aatggcacc  gggggaaga  aaagcctcc  cgactctgc  ttctctttt  600
cagtcttgc  609



<210> 4170
<211> 1258
<212> PRT
<213> Rattus norvegicus
<308> Q64568
<400> 4170

Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln 
  1               5                  10                  15
Gln Gln Arg Glu Val Pro His Val Gly Gly Phe Gly Cys Thr Leu Ala 
             20                  25                  30
Glu Leu Arg Ser Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys 
         35                  40                  45
Ile Gln Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys 
     50                  55                  60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys 
 65                  70                  75                  80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys 
                 85                  90                  95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
             100                105                110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala 
         115                120                125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala 
     130                135                140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile 
 145                150                155                160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp 
                 165                170                175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu 
             180                185                190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val 
         195                200                205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu 
     210                215                220
Leu Pro Ala Asp Gly Val Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp 
 225                230                235                240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp 
                 245                250                255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly 
             260                265                270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile 
         275                280                285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys 
     290                295                300
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala 
 305                310                315                320
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser 
                 325                330                335
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Val 
             340                345                350
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala 
         355                360                365
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile 
     370                375                380
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Asp Gly Arg 
 385                390                395                400
Val Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys 
                 405                410                415
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly 
             420                425                430
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met 
         435                440                445
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met 
     450                455                460
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr 
 465                470                475                480
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys 
                 485                490                495
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu 
             500                505                510
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro 
         515                520                525
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu 
     530                535                540
Cys Ala Leu Leu Gly Phe Ile Leu Asp Leu Lys Arg Asp Phe Gln Pro 
 545                550                555                560
Val Arg Glu Gln Ile Pro Glu Asp Gln Leu Tyr Lys Val Tyr Thr Phe 
                 565                570                575
Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Met Pro Asp Gly 
             580                585                590
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys 
         595                600                605
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro 
     610                615                620
Arg Asp Arg Asp Asp Met Val Lys Lys Ile Ile Glu Pro Met Ala Cys 
 625                630                635                640
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Ser Ala Ile 
                 645                650                655
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr 
             660                665                670
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro 
         675                680                685
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val 
     690                695                700
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly 
 705                710                715                720
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe 
                 725                730                735
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu 
             740                745                750
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr 
         755                760                765
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu 
     770                775                780
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro 
 785                790                795                800
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr 
                 805                810                815
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe 
             820                825                830
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser 
         835                840                845
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val 
     850                855                860
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys 
 865                870                875                880
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser 
                 885                890                895
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys 
             900                905                910
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn 
         915                920                925
Ile Leu Gly His Ala Val Tyr Gln Leu Thr Ile Ile Phe Thr Leu Leu 
     930                935                940
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro 
 945                950                955                960
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe 
                 965                970                975
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly 
             980                985                990
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr 
         995                1000                1005
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly 
     1010                1015                1020
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp 
 1025                1030                1035                1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala 
                 1045                1050                1055
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly 
             1060                1065                1070
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu 
         1075                1080                1085
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp 
     1090                1095                1100
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Glu Val Val Ser Thr 
 1105                1110                1115                1120
Phe Lys Arg Ser Gly Ser Phe Gln Gly Ala Val Arg Arg Arg Ser Ser 
                 1125                1130                1135
Val Leu Ser Gln Leu His Asp Val Thr Asn Leu Ser Thr Pro Thr His 
             1140                1145                1150
Ile Arg Val Val Lys Ala Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu 
         1155                1160                1165
Lys Pro Glu Ser Lys Ser Cys Ile His Asn Phe Met Ala Thr Pro Glu 
     1170                1175                1180
Phe Leu Ile Asn Asp Tyr Thr His Asn Ile Pro Leu Ile Asp Asp Thr 
 1185                1190                1195                1200
Asp Val Asp Glu Asn Glu Glu Arg Leu Arg Ala Pro Pro Pro Pro Pro 
                 1205                1210                1215
Pro Asn Gln Asn Asn Asn Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr 
             1220                1225                1230
His Ala Thr Lys Ser Ala Thr Ser Ser Ala Phe Ser Ser Arg Pro Gly 
         1235                1240                1245
Ser Pro Leu His Ser Met Glu Thr Ser Leu 
     1250                1255



<210> 4171
<211> 257
<212> DNA
<213> Homo sapiens
<308> U15689
<400> 4171

cagacgcag  tgtgttggg  cggaaaaaa  atgttgaga  ctaccgaag  aggataagg  60
agtattgcc  aacacagat  gaggtagtg  gtaccttca  gagaagcgg  tcagttcag  120
gtgctgtgc  ccggcggtc  tcggtcctc  gccagcttc  tgacgtaac  aatctttct  180
cccctactc  cgcaattct  tctgctgcc  atcctacca  tgctgctgg  aatccgggt  240
gtgaaagcg  tccgtag  257



<210> 4172
<211> 1220
<212> PRT
<213> Homo sapiens
<308> Q16720
<400> 4172

Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln 
  1               5                  10                  15
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala 
             20                  25                  30
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys 
         35                  40                  45
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys 
     50                  55                  60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys 
 65                  70                  75                  80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys 
                 85                  90                  95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
             100                105                110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala 
         115                120                125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala 
     130                135                140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile 
 145                150                155                160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp 
                 165                170                175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu 
             180                185                190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val 
         195                200                205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu 
     210                215                220
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp 
 225                230                235                240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp 
                 245                250                255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly 
             260                265                270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile 
         275                280                285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys 
     290                295                300
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala 
 305                310                315                320
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser 
                 325                330                335
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala 
             340                345                350
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala 
         355                360                365
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile 
     370                375                380
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg 
 385                390                395                400
Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys 
                 405                410                415
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly 
             420                425                430
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met 
         435                440                445
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met 
     450                455                460
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr 
 465                470                475                480
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys 
                 485                490                495
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu 
             500                505                510
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro 
         515                520                525
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu 
     530                535                540
Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro 
 545                550                555                560
Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe 
                 565                570                575
Asn Ser Val Arg Lys Ser Met Ser Thr Val Val Arg Met Pro Asp Gly 
             580                585                590
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys 
         595                600                605
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro 
     610                615                620
Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys 
 625                630                635                640
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Tyr Ala Gly 
                 645                650                655
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr 
             660                665                670
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro 
         675                680                685
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val 
     690                695                700
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly 
 705                710                715                720
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe 
                 725                730                735
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu 
             740                745                750
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr 
         755                760                765
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu 
     770                775                780
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro 
 785                790                795                800
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr 
                 805                810                815
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe 
             820                825                830
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser 
         835                840                845
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val 
     850                855                860
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys 
 865                870                875                880
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser 
                 885                890                895
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys 
             900                905                910
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn 
         915                920                925
Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu 
     930                935                940
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro 
 945                950                955                960
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe 
                 965                970                975
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly 
             980                985                990
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr 
         995                1000                1005
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly 
     1010                1015                1020
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp 
 1025                1030                1035                1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala 
                 1045                1050                1055
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly 
             1060                1065                1070
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu 
         1075                1080                1085
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp 
     1090                1095                1100
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile Arg Val Val Lys Ala 
 1105                1110                1115                1120
Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser Lys Thr 
                 1125                1130                1135
Ser Ile His Asn Phe Met Ala Thr Pro Glu Phe Leu Ile Asn Asp Tyr 
             1140                1145                1150
Thr His Asn Ile Pro Leu Ile Asp Asp Thr Asp Val Asp Glu Asn Glu 
         1155                1160                1165
Glu Arg Leu Arg Ala Pro Pro Pro Pro Ser Pro Asn Gln Asn Asn Asn 
     1170                1175                1180
Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr His Val Thr Lys Ser Ala 
 1185                1190                1195                1200
Thr Ser Ser Val Phe Ser Ser Ser Pro Gly Ser Pro Leu His Ser Val 
                 1205                1210                1215
Glu Thr Ser Leu 
             1220



<210> 4173
<211> 3083
<212> DNA
<213> Rattus norvegicus
<308> M96853
<400> 4173

gcaaaactc  aatgaagtc  gagccccct  ctcgccgcc  cggccaggc  ccccaacat  60
gactgtctc  gtatagtga  aaccaagaa  taccgctac  aagatgaag  cacgccccc  120
ctggaacac  gcccggccc  cctccccaa  caggccaat  ctccccctg  gattgtcaa  180
acggacacc  tagaagccc  aggatatga  ttgcaggtg  atggaacag  gggggagat  240
gagtatgag  agatcacat  ggaaagggg  aactcaggt  tgggcttca  catcgcagg  300
ggcactgac  acccgcaca  cggtgacga  ccgtccatt  ttatcacca  gatcattcc  360
ggtggggct  cagcccagg  tggccgcct  agggtcaat  acagcatcc  gtttgtaaa  420
gaagtggat  ttcgggagg  gacccattc  gctgcggtg  aggccctca  agaggcagg  480
tccatcgtt  gcctctatg  catgcgccg  aaaccccca  ccgaaaagg  catggagat  540
aaactcatc  aagggccta  aggacttgg  ttcagcatt  cggggggcg  tgggaacca  600
cacatccct  gagataaca  catctatgt  acgaagatc  tcgaaggag  tgctgccca  660
aaggatggc  ggttgcaga  tggagacaa  atcctggcg  tcaacagtg  ggggctgga  720
gacgtcatg  acgaggatg  cgtggcagc  ctgaagaac  catatgacg  tgtgtacct  780
aaggtggcc  agcccagca  tgcctacct  agtgacagc  atgctcccc  agacatcac  840
acctcgtat  ctcagcacc  ggacaatga  atcagtcat  gcagctact  gggcactga  900
taccccaca  ccatgaccc  cacttcccc  cggcgctac  cccctgtgg  caaggacct  960
ctgggggag  aagacattc  ccgggaacc  aggcggatc  tgatccatc  gggctccac  1020
ggcctgggc  tcaacatcg  gggcggcga  gatggtgaa  gcatcttca  ctccttcat  1080
cttgctggg  gtccagccg  cctcagtgg  gagctacgg  agggggacc  gatcctgtc  1140
gtcaatggt  ttgacctcc  caatgccag  cacgaacag  ctgccattg  cctgaagaa  1200
gcgggtcag  cggtcacga  catcgctca  tataaacca  aagagtata  tcgattcga  1260
gccaagatc  atgatcttc  ggaacagct  atgaatagt  gcctaggct  agggactgc  1320
tccttgcga  gcaacccca  gaggggctt  tacattagg  ccctgtttg  ttacgacaa  1380
accaaggac  gcggtttct  gagccaggc  ctgagcttc  gcttcgggg  tgtgcttca  1440
gtcattgac  ctggtgacg  agagtggtg  caagcacgg  gggtccact  cgacagtga  1500
accgacgac  ttggcttca  tcccagcaa  cggcgggtc  agcgacgag  gtggtcaag  1560
ttaaaggcc  aggactggg  ctccagctc  ggatcacag  gtcgagaag  ctcggttct  1620
agctatgag  cggtgaccc  gatggaagt  cactatgct  gtcccatca  catccttgg  1680
cccaccaaa  accgtgcca  cgatgatct  ctctccgag  tccccgaca  gtttggatc  1740
tgtgtccct  atacgacac  tcctaagcg  gaatatgag  tagacggcc  ggattacca  1800
tttgtctcc  cccgggaga  aatggagaa  gacatccag  cacacaagt  cattgaggc  1860
ggccagtac  acagccacc  ctatgggac  agcgtccag  ctgtgcgag  ggtagcaga  1920
caggggaag  actgcatcc  cgatgtctc  gccaatgcc  tgcggcggc  gcaggcggc  1980
cacctgcac  ccatcgcca  cttcatccg  ccccgctcc  tggagaatg  gctagagat  2040
aataagcgg  tcacagagg  gcaagcccg  aaagccttc  acagagcca  gaagctgga  2100
caggagttc  cagagtgct  ctcagccat  gtagagggc  acagctttg  agagatcta  2160
cacaaagtg  aacgtgtca  tgaagacct  tcaggcccc  acatctggg  cccagcccg  2220
gagagactc  gattcctgc  ctggcttgg  ctggactca  cctgcctcc  ccacatggg  2280
ccttggtgt  gactgaata  cccaagtcc  ttgtacccc  gcctccctt  ccacccttc  2340
tatttattt  ctttctaac  ggatcgagc  cactggagg  gggacactc  tctgcatgt  2400
tccctgcaa  ccagatcag  gcccctgga  cccaagaac  tggggtctg  gggagggga  2460
ctgggctcc  ggttccgag  ccttgctcc  taggacccc  acccccgcc  gcccccatg  2520
acacataga  ccactgggg  cctctgccc  ccccatttt  tcccacaca  attccagaa  2580
tcagggccc  tctcaagga  tacccgctg  agggatgca  ggccacagg  ttccgcgct  2640
tcctgaggc  ggggctggg  tcacccctg  cccatcata  ctccccatg  catttgagt  2700
ctcatttat  ttctccatt  ttttcttct  aaaggtggt  tttgggggg  gacgcatgg  2760
ggctctcct  agggtcccc  gtctttcac  cacctccca  cttttttct  tgctggttt  2820
catgagtgg  aggtctaac  gtgggcttt  ttttttcct  ggattttat  ttattttat  2880
tcattttat  tttttggga  aaggggagg  atgggtcta  ggagtgggg  atatgggag  2940
ggggtgggg  ggcaagggg  caggggttg  gtgtccggg  gccagggga  gacaggaaa  3000
gctgccgcc  tctgcaatt  atttatttt  tcttttgag  gagtgaaag  aagagacag  3060
cacttgaaa  aaaaaaaaa  aaa  3083



<210> 4174
<211> 724
<212> PRT
<213> Rattus norvegicus
<308> P31016
<400> 4174

Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 
  1               5                  10                  15
Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His Leu Pro Asn Gln 
             20                  25                  30
Ala Asn Ser Pro Pro Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro 
         35                  40                  45
Gly Tyr Glu Leu Gln Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu 
     50                  55                  60
Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala 
 65                  70                  75                  80
Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile 
                 85                  90                  95
Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg 
             100                105                110
Val Asn Asp Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val 
         115                120                125
Thr His Ser Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val 
     130                135                140
Arg Leu Tyr Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu 
 145                150                155                160
Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly 
                 165                170                175
Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr 
             180                185                190
Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile 
         195                200                205
Gly Asp Lys Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met 
     210                215                220
His Glu Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr 
 225                230                235                240
Leu Lys Val Ala Lys Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala 
                 245                250                255
Pro Pro Asp Ile Thr Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile 
             260                265                270
Ser His Ser Ser Tyr Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro 
         275                280                285
Thr Ser Pro Arg Arg Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu 
     290                295                300
Glu Asp Ile Pro Arg Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser 
 305                310                315                320
Thr Gly Leu Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile 
                 325                330                335
Phe Ile Ser Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu 
             340                345                350
Leu Arg Lys Gly Asp Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg 
         355                360                365
Asn Ala Ser His Glu Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln 
     370                375                380
Thr Val Thr Ile Ile Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe 
 385                390                395                400
Glu Ala Lys Ile His Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu 
                 405                410                415
Gly Ser Gly Thr Ala Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr 
             420                425                430
Ile Arg Ala Leu Phe Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu 
         435                440                445
Ser Gln Ala Leu Ser Phe Arg Phe Gly Asp Val Leu His Val Ile Asp 
     450                455                460
Ala Gly Asp Glu Glu Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser 
 465                470                475                480
Glu Thr Asp Asp Ile Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg 
                 485                490                495
Arg Glu Trp Ser Arg Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly 
             500                505                510
Ser Gln Gly Arg Glu Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln 
         515                520                525
Met Glu Val His Tyr Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys 
     530                535                540
Asp Arg Ala Asn Asp Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly 
 545                550                555                560
Ser Cys Val Pro His Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp 
                 565                570                575
Gly Arg Asp Tyr His Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp 
             580                585                590
Ile Gln Ala His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu 
         595                600                605
Tyr Gly Thr Ser Val Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys 
     610                615                620
His Cys Ile Leu Asp Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala 
 625                630                635                640
Ala His Leu His Pro Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu 
                 645                650                655
Asn Val Leu Glu Ile Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys 
             660                665                670
Ala Phe Asp Arg Ala Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe 
         675                680                685
Ser Ala Ile Val Glu Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val 
     690                695                700
Lys Arg Val Ile Glu Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala 
 705                710                715                720
Arg Glu Arg Leu 
                 725



<210> 4176
<211> 767
<212> PRT
<213> Homo sapiens
<308> AAD56173
<400> 4176

Met Ser Gln Arg Pro Arg Ala Pro Arg Ser Ala Leu Trp Leu Leu Ala 
  1               5                  10                  15
Pro Pro Leu Leu Arg Trp Ala Pro Pro Leu Leu Thr Val Leu His Ser 
             20                  25                  30
Asp Leu Phe Gln Ala Leu Leu Asp Ile Leu Asp Tyr Tyr Glu Ala Ser 
         35                  40                  45
Leu Ser Glu Ser Gln Lys Tyr Arg Tyr Gln Asp Glu Asp Thr Pro Pro 
     50                  55                  60
Leu Glu His Ser Pro Ala His Leu Pro Asn Gln Ala Asn Ser Pro Pro 
 65                  70                  75                  80
Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro Gly Tyr Glu Leu Gln 
                 85                  90                  95
Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu Glu Ile Thr Leu Glu 
             100                105                110
Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly Thr Asp Asn 
         115                120                125
Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys Ile Ile Pro 
     130                135                140
Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn Asp Ser Ile 
 145                150                155                160
Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His Ser Ala Ala 
                 165                170                175
Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu Tyr Val Met 
             180                185                190
Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu Ile Lys 
         195                200                205
Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly Asn Gln 
     210                215                220
His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile Glu Gly 
 225                230                235                240
Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys Ile Leu 
                 245                250                255
Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp Ala Val 
             260                265                270
Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val Ala Lys 
         275                280                285
Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala Pro Pro Asp Ile Thr 
     290                295                300
Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile Ser His Ser Ser Tyr 
 305                310                315                320
Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro Thr Ser Pro Arg Arg 
                 325                330                335
Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu Glu Asp Ile Pro Arg 
             340                345                350
Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser Thr Gly Leu Gly Phe 
         355                360                365
Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe Ile 
     370                375                380
Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly Asp 
 385                390                395                400
Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg Asn Ala Ser His Glu 
                 405                410                415
Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln Thr Val Thr Ile Ile 
             420                425                430
Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys Ile His 
         435                440                445
Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu Gly Ser Gly Thr Ala 
     450                455                460
Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr Ile Arg Ala Leu Phe 
 465                470                475                480
Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu Ser Gln Ala Leu Ser 
                 485                490                495
Phe Arg Phe Gly Asp Val Leu His Val Ile Asp Ala Ser Asp Glu Glu 
             500                505                510
Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser Glu Thr Asp Asp Ile 
         515                520                525
Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg Arg Glu Trp Ser Arg 
     530                535                540
Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly Ser Gln Gly Arg Glu 
 545                550                555                560
Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln Met Glu Val His Tyr 
                 565                570                575
Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys Asp Arg Ala Asn Asp 
             580                585                590
Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val Pro His 
         595                600                605
Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp Gly Arg Asp Tyr His 
     610                615                620
Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp Ile Gln Ala His Lys 
 625                630                635                640
Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu Tyr Gly Thr Ser Val 
                 645                650                655
Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys His Cys Ile Leu Asp 
             660                665                670
Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala Ala His Leu His Pro 
         675                680                685
Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu Asn Val Leu Glu Ile 
     690                695                700
Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys Ala Phe Asp Arg Ala 
 705                710                715                720
Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe Ser Ala Ile Val Glu 
                 725                730                735
Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val Lys Arg Val Ile Glu 
             740                745                750
Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala Arg Glu Arg Leu 
         755                760                765



<210> 4177
<211> 3083
<212> DNA
<213> Rattus norvegicus
<308> M96853
<400> 4177

gcaaaactc  aatgaagtc  gagccccct  ctcgccgcc  cggccaggc  ccccaacat  60
gactgtctc  gtatagtga  aaccaagaa  taccgctac  aagatgaag  cacgccccc  120
ctggaacac  gcccggccc  cctccccaa  caggccaat  ctccccctg  gattgtcaa  180
acggacacc  tagaagccc  aggatatga  ttgcaggtg  atggaacag  gggggagat  240
gagtatgag  agatcacat  ggaaagggg  aactcaggt  tgggcttca  catcgcagg  300
ggcactgac  acccgcaca  cggtgacga  ccgtccatt  ttatcacca  gatcattcc  360
ggtggggct  cagcccagg  tggccgcct  agggtcaat  acagcatcc  gtttgtaaa  420
gaagtggat  ttcgggagg  gacccattc  gctgcggtg  aggccctca  agaggcagg  480
tccatcgtt  gcctctatg  catgcgccg  aaaccccca  ccgaaaagg  catggagat  540
aaactcatc  aagggccta  aggacttgg  ttcagcatt  cggggggcg  tgggaacca  600
cacatccct  gagataaca  catctatgt  acgaagatc  tcgaaggag  tgctgccca  660
aaggatggc  ggttgcaga  tggagacaa  atcctggcg  tcaacagtg  ggggctgga  720
gacgtcatg  acgaggatg  cgtggcagc  ctgaagaac  catatgacg  tgtgtacct  780
aaggtggcc  agcccagca  tgcctacct  agtgacagc  atgctcccc  agacatcac  840
acctcgtat  ctcagcacc  ggacaatga  atcagtcat  gcagctact  gggcactga  900
taccccaca  ccatgaccc  cacttcccc  cggcgctac  cccctgtgg  caaggacct  960
ctgggggag  aagacattc  ccgggaacc  aggcggatc  tgatccatc  gggctccac  1020
ggcctgggc  tcaacatcg  gggcggcga  gatggtgaa  gcatcttca  ctccttcat  1080
cttgctggg  gtccagccg  cctcagtgg  gagctacgg  agggggacc  gatcctgtc  1140
gtcaatggt  ttgacctcc  caatgccag  cacgaacag  ctgccattg  cctgaagaa  1200
gcgggtcag  cggtcacga  catcgctca  tataaacca  aagagtata  tcgattcga  1260
gccaagatc  atgatcttc  ggaacagct  atgaatagt  gcctaggct  agggactgc  1320
tccttgcga  gcaacccca  gaggggctt  tacattagg  ccctgtttg  ttacgacaa  1380
accaaggac  gcggtttct  gagccaggc  ctgagcttc  gcttcgggg  tgtgcttca  1440
gtcattgac  ctggtgacg  agagtggtg  caagcacgg  gggtccact  cgacagtga  1500
accgacgac  ttggcttca  tcccagcaa  cggcgggtc  agcgacgag  gtggtcaag  1560
ttaaaggcc  aggactggg  ctccagctc  ggatcacag  gtcgagaag  ctcggttct  1620
agctatgag  cggtgaccc  gatggaagt  cactatgct  gtcccatca  catccttgg  1680
cccaccaaa  accgtgcca  cgatgatct  ctctccgag  tccccgaca  gtttggatc  1740
tgtgtccct  atacgacac  tcctaagcg  gaatatgag  tagacggcc  ggattacca  1800
tttgtctcc  cccgggaga  aatggagaa  gacatccag  cacacaagt  cattgaggc  1860
ggccagtac  acagccacc  ctatgggac  agcgtccag  ctgtgcgag  ggtagcaga  1920
caggggaag  actgcatcc  cgatgtctc  gccaatgcc  tgcggcggc  gcaggcggc  1980
cacctgcac  ccatcgcca  cttcatccg  ccccgctcc  tggagaatg  gctagagat  2040
aataagcgg  tcacagagg  gcaagcccg  aaagccttc  acagagcca  gaagctgga  2100
caggagttc  cagagtgct  ctcagccat  gtagagggc  acagctttg  agagatcta  2160
cacaaagtg  aacgtgtca  tgaagacct  tcaggcccc  acatctggg  cccagcccg  2220
gagagactc  gattcctgc  ctggcttgg  ctggactca  cctgcctcc  ccacatggg  2280
ccttggtgt  gactgaata  cccaagtcc  ttgtacccc  gcctccctt  ccacccttc  2340
tatttattt  ctttctaac  ggatcgagc  cactggagg  gggacactc  tctgcatgt  2400
tccctgcaa  ccagatcag  gcccctgga  cccaagaac  tggggtctg  gggagggga  2460
ctgggctcc  ggttccgag  ccttgctcc  taggacccc  acccccgcc  gcccccatg  2520
acacataga  ccactgggg  cctctgccc  ccccatttt  tcccacaca  attccagaa  2580
tcagggccc  tctcaagga  tacccgctg  agggatgca  ggccacagg  ttccgcgct  2640
tcctgaggc  ggggctggg  tcacccctg  cccatcata  ctccccatg  catttgagt  2700
ctcatttat  ttctccatt  ttttcttct  aaaggtggt  tttgggggg  gacgcatgg  2760
ggctctcct  agggtcccc  gtctttcac  cacctccca  cttttttct  tgctggttt  2820
catgagtgg  aggtctaac  gtgggcttt  ttttttcct  ggattttat  ttattttat  2880
tcattttat  tttttggga  aaggggagg  atgggtcta  ggagtgggg  atatgggag  2940
ggggtgggg  ggcaagggg  caggggttg  gtgtccggg  gccagggga  gacaggaaa  3000
gctgccgcc  tctgcaatt  atttatttt  tcttttgag  gagtgaaag  aagagacag  3060
cacttgaaa  aaaaaaaaa  aaa  3083



<210> 4178
<211> 724
<212> PRT
<213> Rattus norvegicus
<308> P31016
<400> 4178

Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 
  1               5                  10                  15
Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His Leu Pro Asn Gln 
             20                  25                  30
Ala Asn Ser Pro Pro Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro 
         35                  40                  45
Gly Tyr Glu Leu Gln Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu 
     50                  55                  60
Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala 
 65                  70                  75                  80
Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile 
                 85                  90                  95
Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg 
             100                105                110
Val Asn Asp Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val 
         115                120                125
Thr His Ser Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val 
     130                135                140
Arg Leu Tyr Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu 
 145                150                155                160
Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly 
                 165                170                175
Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr 
             180                185                190
Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile 
         195                200                205
Gly Asp Lys Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met 
     210                215                220
His Glu Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr 
 225                230                235                240
Leu Lys Val Ala Lys Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala 
                 245                250                255
Pro Pro Asp Ile Thr Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile 
             260                265                270
Ser His Ser Ser Tyr Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro 
         275                280                285
Thr Ser Pro Arg Arg Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu 
     290                295                300
Glu Asp Ile Pro Arg Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser 
 305                310                315                320
Thr Gly Leu Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile 
                 325                330                335
Phe Ile Ser Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu 
             340                345                350
Leu Arg Lys Gly Asp Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg 
         355                360                365
Asn Ala Ser His Glu Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln 
     370                375                380
Thr Val Thr Ile Ile Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe 
 385                390                395                400
Glu Ala Lys Ile His Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu 
                 405                410                415
Gly Ser Gly Thr Ala Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr 
             420                425                430
Ile Arg Ala Leu Phe Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu 
         435                440                445
Ser Gln Ala Leu Ser Phe Arg Phe Gly Asp Val Leu His Val Ile Asp 
     450                455                460
Ala Gly Asp Glu Glu Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser 
 465                470                475                480
Glu Thr Asp Asp Ile Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg 
                 485                490                495
Arg Glu Trp Ser Arg Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly 
             500                505                510
Ser Gln Gly Arg Glu Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln 
         515                520                525
Met Glu Val His Tyr Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys 
     530                535                540
Asp Arg Ala Asn Asp Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly 
 545                550                555                560
Ser Cys Val Pro His Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp 
                 565                570                575
Gly Arg Asp Tyr His Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp 
             580                585                590
Ile Gln Ala His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu 
         595                600                605
Tyr Gly Thr Ser Val Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys 
     610                615                620
His Cys Ile Leu Asp Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala 
 625                630                635                640
Ala His Leu His Pro Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu 
                 645                650                655
Asn Val Leu Glu Ile Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys 
             660                665                670
Ala Phe Asp Arg Ala Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe 
         675                680                685
Ser Ala Ile Val Glu Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val 
     690                695                700
Lys Arg Val Ile Glu Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala 
 705                710                715                720
Arg Glu Arg Leu 
                 725



<210> 4180
<211> 767
<212> PRT
<213> Homo sapiens
<308> AAD56173
<400> 4180

Met Ser Gln Arg Pro Arg Ala Pro Arg Ser Ala Leu Trp Leu Leu Ala 
  1               5                  10                  15
Pro Pro Leu Leu Arg Trp Ala Pro Pro Leu Leu Thr Val Leu His Ser 
             20                  25                  30
Asp Leu Phe Gln Ala Leu Leu Asp Ile Leu Asp Tyr Tyr Glu Ala Ser 
         35                  40                  45
Leu Ser Glu Ser Gln Lys Tyr Arg Tyr Gln Asp Glu Asp Thr Pro Pro 
     50                  55                  60
Leu Glu His Ser Pro Ala His Leu Pro Asn Gln Ala Asn Ser Pro Pro 
 65                  70                  75                  80
Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro Gly Tyr Glu Leu Gln 
                 85                  90                  95
Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu Glu Ile Thr Leu Glu 
             100                105                110
Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly Thr Asp Asn 
         115                120                125
Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys Ile Ile Pro 
     130                135                140
Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn Asp Ser Ile 
 145                150                155                160
Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His Ser Ala Ala 
                 165                170                175
Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu Tyr Val Met 
             180                185                190
Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu Ile Lys 
         195                200                205
Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly Asn Gln 
     210                215                220
His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile Glu Gly 
 225                230                235                240
Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys Ile Leu 
                 245                250                255
Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp Ala Val 
             260                265                270
Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val Ala Lys 
         275                280                285
Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala Pro Pro Asp Ile Thr 
     290                295                300
Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile Ser His Ser Ser Tyr 
 305                310                315                320
Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro Thr Ser Pro Arg Arg 
                 325                330                335
Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu Glu Asp Ile Pro Arg 
             340                345                350
Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser Thr Gly Leu Gly Phe 
         355                360                365
Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe Ile 
     370                375                380
Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly Asp 
 385                390                395                400
Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg Asn Ala Ser His Glu 
                 405                410                415
Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln Thr Val Thr Ile Ile 
             420                425                430
Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys Ile His 
         435                440                445
Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu Gly Ser Gly Thr Ala 
     450                455                460
Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr Ile Arg Ala Leu Phe 
 465                470                475                480
Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu Ser Gln Ala Leu Ser 
                 485                490                495
Phe Arg Phe Gly Asp Val Leu His Val Ile Asp Ala Ser Asp Glu Glu 
             500                505                510
Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser Glu Thr Asp Asp Ile 
         515                520                525
Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg Arg Glu Trp Ser Arg 
     530                535                540
Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly Ser Gln Gly Arg Glu 
 545                550                555                560
Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln Met Glu Val His Tyr 
                 565                570                575
Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys Asp Arg Ala Asn Asp 
             580                585                590
Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val Pro His 
         595                600                605
Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp Gly Arg Asp Tyr His 
     610                615                620
Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp Ile Gln Ala His Lys 
 625                630                635                640
Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu Tyr Gly Thr Ser Val 
                 645                650                655
Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys His Cys Ile Leu Asp 
             660                665                670
Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala Ala His Leu His Pro 
         675                680                685
Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu Asn Val Leu Glu Ile 
     690                695                700
Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys Ala Phe Asp Arg Ala 
 705                710                715                720
Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe Ser Ala Ile Val Glu 
                 725                730                735
Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val Lys Arg Val Ile Glu 
             740                745                750
Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala Arg Glu Arg Leu 
         755                760                765



<210> 4181
<211> 3800
<212> DNA
<213> Rattus norvegicus
<308> M99567
<400> 4181

gccgtggtg  agaccctgc  gcgcgggag  aaattcatc  aatgggacg  ggaggcctc  60
agtcggaac  tggtgaccc  gcgactgga  cccaatggc  tcttcttgt  ctggacagg  120
cccaacatg  aggtggaca  actggacat  agctccatc  gggacacaa  gacaggtcg  180
tatgcccgc  tgcccaagg  ccccaagat  cgagaggta  tgggctttg  gggtcctga  240
acccggctg  aggagaaac  gatgacagt  gtagcagga  cagatccag  aaacaccac  300
ttcttgaac  tcatggccg  gcaagatga  acagtcaag  tctggtcag  ggagttgtt  360
aagctggct  tgaacatac  ggctcagaa  gctccggaa  acgttcttc  gaaagcata  420
acgaaactg  agctgcagg  gaaccagga  ggacggatt  cagtcaaga  cattctgaa  480
atgttctcc  cggacaaga  gcgggtgga  actgcactg  tctgcggcc  caacttcaa  540
cggagtgag  ccattcggc  tgatgagtt  tccttggaa  tcttcgagc  gttcttgaa  600
aagctgttg  tgcgaccgg  tattgacaa  atcctgctg  agataggtg  caagggcaa  660
ccgtacctc  ctctggagc  gctcatgga  tttatcaac  agaagcaaa  agacccaag  720
ctcaacgag  tgctgtacc  accgcttcg  tcctcacag  ctcggctgc  cattgagaa  780
tatgagccg  acaaacagt  cctggagcg  gaccagatg  ctatggagg  tttcagccg  840
tatctggga  gggaggaga  tggcatcct  cccctggag  ccctggatc  gagcatgga  900
atgacgcag  cactgagcg  atacttcat  aattcttca  acaatacct  tctcactgc  960
ggccagctg  ctggaacat  gtcagtgga  atgtaccgc  aggcgctgc  gtggggctg  1020
cgttgtgtg  agctggatg  atggaaggg  cggccaccg  aggaagagc  cttcattac  1080
catggtttc  ccatgacca  tgaggtgcc  ttgcgtgat  tgttagagg  catcgccga  1140
acagccttc  agacctcac  ctaccctgt  attctctcc  tcgaaaacc  tgtggactc  1200
gcaaaacag  aggccaaga  ggcagagta  tgccgctct  tctttgggg  agcgctgct  1260
attgaccca  tggacaagt  cccgctgtc  gcgggcacc  cccttccta  tccacagga  1320
ctgatgggc  gtatcctgg  gaagaataa  aagcggcat  ggcccagca  aggtgtccc  1380
gacagctcc  tggccaagc  gcctctgga  cagagcaat  cagccctga  tgagagctc  1440
gctgccaca  agccctcct  accccagct  gggtccccc  gctctgaca  ctgccctgg  1500
ctaagcaat  gggaagagg  gggacttga  aagaccagc  tggagcctc  gaagtctct  1560
ggtgaggag  gcctcaacc  aggacctaa  gttctcatg  ctgaccgtg  ccgagagga  1620
gaggaggaa  atgaagaag  ggaggaaac  acggatcca  aaaagccca  caccgatga  1680
ggcacagcc  gcagtgagg  caacgccac  gaggagatg  cgacactcg  caattacgt  1740
gagcccgtc  agttcaagt  ctttgaggc  tctcgaaaa  ggaacaagt  ctttgagat  1800
tcgtccttt  tggagacca  ggcgatgga  cagctgacc  agagcccca  ggagttcgt  1860
gaatacaac  aacagcagc  tagtcgcat  taccccaag  ggacccgtg  ggactcctc  1920
aactacatg  ctcagctct  ctggaacgt  ggctgtcag  ttgttgccc  caacttcca  1980
accttggat  tgccaatgc  gctcaacgc  ggcgtgttt  agtacaacg  gcgcagtgg  2040
tacttgctc  agcctgagt  tatgcggcg  ccggacaag  cttttgacc  cttcactga  2100
gtcatcgta  atggcatag  ggccaacgc  ttgcgggtc  aggtgattt  ggggcagtt  2160
ctgtctgac  ggaaggtgg  catctatgt  gaggtggac  tgtttggtc  cccagttga  2220
acaagacgc  aatatcgca  acggacatc  caggggaac  cattcaacc  tgtgtggga  2280
gaagaaccc  ttgacttcc  caaggttgt  ctgcccacg  tggcctcac  tcgcattgc  2340
gcctttgag  agggtggca  atttgttgg  catcgtatc  tgcctgtct  tgctatccg  2400
tcaggatac  actacgtct  cctgcgaaa  gaggccaac  aaccgttgt  cctgcctgc  2460
ctgcttatc  acactgaag  ttctgacta  atcccagat  accaccagg  ctatgcgga  2520
gccttgatc  accccatca  gcacgtcag  ctaatggac  agcgggcca  gcaactggc  2580
gctctcatt  gggagagtg  ggctcaggc  agtacagaa  tgtgtcagg  gaccccgtc  2640
caacagcaa  gctcacagc  ctcctccaa  cccgtacct  acccactgg  tgactcacc  2700
cgatggccc  caggtccta  cacctcccc  actagcacc  ccctcagta  cccagggca  2760
cgagatgat  tgatcgcca  catcctttc  gaggtgacc  caacacccc  agaggagct  2820
cgaagccac  aggctatgg  gaagctccg  agccggcag  atcgagacc  gagggaact  2880
cataaaaaa  accagcgca  ggctgtggc  ctcacccgc  gccttctgg  tggcctggc  2940
caggccagg  ctgagggga  gtgccggcc  tcctccagc  ccctgagca  ggccaccaa  3000
gtggaagac  tgaaggagg  agaaaaaga  gcagccaga  agtatcgag  gttccagaa  3060
cgacaagta  agagcctgc  ggagctgag  gaggcccag  cagatgcag  gacagaacg  3120
aggctggag  atctgaaac  ggctcagca  cggctcagg  aggttgtcc  ggacgcaca  3180
acgactcag  tcaagaggc  gaaggagtt  aatgaaagg  agaagaagg  gcttcagaa  3240
atcctggac  ggaagcgca  caacagcat  tcagaggcc  agacaaggg  gaaacacaa  3300
aaggaggtg  aactgacag  gatcaatcg  aggcacatc  ctgagtcag  gaactccat  3360
aggaggctg  aagaggccc  gaagcagcg  cacgaacgc  tcttggcag  gcaacagca  3420
gtcctccag  agctagtgg  agaggagcc  aagctggtg  cccagctga  ccaggagtg  3480
caggaacag  gagagaggc  gccccagga  atccgtcgg  gcctgctgg  cgagacatc  3540
gagggattg  gggatggcc  cctggtggc  tgtgccagc  atggtcatg  agctgggag  3600
ggtgggcac  agtccggcg  tgactcgga  agccaggag  aaaacaccc  gctttgaac  3660
ggcggagca  gaggtggcc  caagactgg  tgggcactg  gctgtgggt  gaagacact  3720
atactttgg  tttttttta  ccttttatc  ttagaaatt  tattttttt  aaatccgag  3780
caaatcgga  ttcgtgtaca  3800



<210> 4182
<211> 3705
<212> DNA
<213> Homo sapiens
<308> NM_000932
<400> 4182

atggcgggc  cccagcccg  cgtccacgc  ctgcagttg  agccgccca  cgtggtgga  60
accctgcgg  gcgggagta  gttcatcaa  tgggacgag  agacctcca  tcggaacct  120
gtgaccctg  gtgtggacc  caatggctt  ttcttgtac  ggacgggcc  caacatgga  180
gtggacaca  tggacatca  ttccatcag  gacacacgg  caggccggt  cgcccgcct  240
cccaaggac  ccaagatcc  ggaagttct  ggctttggg  gtcccgatg  ccggctgga  300
gagaagctg  tgacggtgg  gtctgggcc  gacccggtg  acacagtgt  cttgaactt  360
atggccgtg  aggatgaca  agccaaggt  tggtctgag  agctattca  gctggctat  420
aacatcctg  ctcagaacg  ctcccggaa  accttcctg  gcaaagcat  cacgaagct  480
aagctgcag  tgaaccagg  tggtcggat  cccgtcaag  acatcctga  gatgttctc  540
gcagacaag  agcgggtgg  gactgcgct  gaatcctgt  gcctcaaat  caaccggag  600
gagtccatc  ggcctgatg  gttttcctt  gaaatcttt  agcggttcc  gaacaagct  660
tgtctgcgg  cggacattg  caagatcct  ctggagata  gcgccaagg  caagccata  720
ctgacgctg  agcagctca  ggacttcat  aaccagaag  aacgcgacc  gagactcaa  780
gaagtgctg  acccgcccc  gcggccctc  caggcccgg  tgctcatcg  aaagtatga  840
cccaaccag  agtttctgg  gcgagacca  atgtccatg  agggcttta  ccgctacct  900
ggaggcgag  agaatggca  cctgcccct  gaagccctg  atctgagca  ggacatgac  960
cagccactg  gtgcctact  catcaactc  tcgcataac  cctatctca  tgcggggca  1020
ctggctggg  cctcgtcgg  ggagatgta  cgccaggca  tactatggg  ctgccgctg  1080
gtggagctg  acgtgtgga  gggacggcc  cctgaggag  aacccttca  tacccacgg  1140
ttcaccatg  ccacagagg  gcctctgcg  gacgtgctg  aggccattg  cgagactgc  1200
ttcaagacc  cgccctacc  cgtcatcct  tccttcgag  accatgtgg  ctcggcaaa  1260
caacaggca  agatggctg  gtactgccg  tccatcttt  gagacgcgc  actcatcga  1320
cctctggac  agtacccgc  ggccccagg  gttcccctg  ccagccccc  ggacctgat  1380
ggccgtatc  tggtgaaga  caagaagcg  caccgaccc  gcgcaggtg  cccagacag  1440
gccgggcgc  agcggcccc  ggagcagag  aattctgcc  tgagcgaga  ctccgcggc  1500
accgagccc  cctccccgc  gctggggtc  cccagctct  acagctgcc  aggcctgag  1560
aatggggag  aggtagggc  tgagaagcc  agcctggag  ctcagaagt  tctgggtga  1620
gagggcctg  accgaggcc  ctatgttct  ggacctgct  accgtgagg  tgaggagga  1680
gatgaggaa  aggaggaac  gacagaccc  aaaaagcca  ctacagatg  gggcacagc  1740
agcagcgag  tgaatgcca  tgaggagat  tccacgctt  tcaactaca  cgaacctgt  1800
aagttcaag  cctttgagg  tgctcgaaa  aggaacaaa  gcttcgaga  gtcgtcctt  1860
gtggagacc  aggccatgg  gcaactgac  aagagcccc  tggagtttg  ggaatacaa  1920
aagcagcag  tcagccgca  ctaccccaa  ggcacccgc  tggactcct  caactacat  1980
ccccagctc  tctggaacg  agggtgcca  cttgttgcg  tcaacttcc  gaccctcga  2040
gtggcgatg  agctcaacg  gggcgtttt  gagtacaac  ggcgcagcg  gtacctgct  2100
aagccggag  tcatgcggc  gccggacaa  tccttcgac  ccttcactg  ggtcatcgt  2160
gatggcatc  tggccaatg  cttgcgggt  aaggtgatc  cagggcagt  cctgtccga  2220
aggaaggtg  gcatctacg  ggaggtgga  atgtttggc  tccctgttg  tacgcggcg  2280
aagtaccgc  cccggacct  tcaggggaa  tcgttcaac  ccgtgtggg  cgaagagcc  2340
ttcgacttc  ccaaggtgg  gctgcccac  ctggcttca  ttcgcattg  agcctttga  2400
gaggggggt  aattcgtag  gcaccggat  ctgcctgtc  ctgccatcc  ctccggata  2460
cactacgtc  gcctgcgga  cgaggccaa  caaccgctg  gcctgccgg  cctgctcat  2520
tacaccgaa  cctcggact  cattcctga  gaccaccag  actatgcgg  ggccctgat  2580
aaccccatt  agcacgtca  cctgatgga  cagagggcc  ggcagctgg  cgccctcat  2640
ggggagagt  aggctcagg  tggccaaga  acgtgccag  acacccagt  tcagcagct  2700
gggtctcag  cgtcctcaa  ccccacccc  agcccactg  atgcctccc  ccgccggcc  2760
cctggcccc  ccacctccc  tgccagcac  tccctcagc  gcccagggc  gcgtgatga  2820
ctcatcgcc  gcatcctct  agaggtggc  cccaccccg  tggatgagc  ccgaggtca  2880
aaggctctg  tcaagctcc  gagccggca  gagcgagac  tgcgggagc  gcgcaagaa  2940
catcagcgg  aggcagtca  cctcacccg  cgcctgctg  atggcctgg  tcaggcaca  3000
gctgagggc  ggtgccggc  gcggccagg  gccctaggt  gggccgctg  tgtggagga  3060
acgaaggag  gggaggacg  ggcaaagcg  tatcaggag  tccagaaca  acaggtgca  3120
agcctgctg  agctgcggg  ggcccaggt  gacgcagag  cccagcgga  gctggaaca  3180
ctgagacag  ctctgcagc  gctcaggga  gtcgtcctt  atgcaaaca  aactcagtt  3240
aagaggctg  aagagatga  cgagaggga  aagaaggag  tgcagaaga  cctggacag  3300
aagcgccat  acagcatct  ggaggccaa  atgagggac  agcataaga  ggaggcgga  3360
ctgacggag  ttaaccgtc  gcacatcac  gagtcagtc  actccatcc  tcggctgga  3420
gaggcccag  agcagcggc  tgaccgtct  gtggctggg  agcagcagg  cctgcaaca  3480
ctggcagaa  aggagccca  gctgctggc  cagctggcc  aggagtgtc  ggagcagcg  3540
gcgaggctc  cccaggaga  ccgccggag  ctgctgggc  agatgccgg  ggggctggg  3600
gacgggcct  tggtggcct  tgccagcaa  ggtcacgca  ccgggagca  cgggcacct  3660
tcgggcgct  actcggaga  ccaggagga  aacacgcag  tctga  3705



<210> 4183
<211> 1234
<212> PRT
<213> Homo sapiens
<308> Q01970
<400> 4183

Met Ala Gly Ala Gln Pro Gly Val His Ala Leu Gln Leu Glu Pro Pro 
  1               5                  10                  15
Thr Val Val Glu Thr Leu Arg Arg Gly Ser Lys Phe Ile Lys Trp Asp 
             20                  25                  30
Glu Glu Thr Ser Ser Arg Asn Leu Val Thr Leu Arg Val Asp Pro Asn 
         35                  40                  45
Gly Phe Phe Leu Tyr Trp Thr Gly Pro Asn Met Glu Val Asp Thr Leu 
     50                  55                  60
Asp Ile Ser Ser Ile Arg Asp Thr Arg Thr Gly Arg Tyr Ala Arg Leu 
 65                  70                  75                  80
Pro Lys Asp Pro Lys Ile Arg Glu Val Leu Gly Phe Gly Gly Pro Asp 
                 85                  90                  95
Ala Arg Leu Glu Glu Lys Leu Met Thr Val Val Ser Gly Pro Asp Pro 
             100                105                110
Val Asn Thr Val Phe Leu Asn Phe Met Ala Val Gln Asp Asp Thr Ala 
         115                120                125
Lys Val Trp Ser Glu Glu Leu Phe Lys Leu Ala Met Asn Ile Leu Ala 
     130                135                140
Gln Asn Ala Ser Arg Asn Thr Phe Leu Arg Lys Ala Tyr Thr Lys Leu 
 145                150                155                160
Lys Leu Gln Val Asn Gln Asp Gly Arg Ile Pro Val Lys Asn Ile Leu 
                 165                170                175
Lys Met Phe Ser Ala Asp Lys Lys Arg Val Glu Thr Ala Leu Glu Ser 
             180                185                190
Cys Gly Leu Lys Phe Asn Arg Ser Glu Ser Ile Arg Pro Asp Glu Phe 
         195                200                205
Ser Leu Glu Ile Phe Glu Arg Phe Leu Asn Lys Leu Cys Leu Arg Pro 
     210                215                220
Asp Ile Asp Lys Ile Leu Leu Glu Ile Gly Ala Lys Gly Lys Pro Tyr 
 225                230                235                240
Leu Thr Leu Glu Gln Leu Met Asp Phe Ile Asn Gln Lys Gln Arg Asp 
                 245                250                255
Pro Arg Leu Asn Glu Val Leu Tyr Pro Pro Leu Arg Pro Ser Gln Ala 
             260                265                270
Arg Leu Leu Ile Glu Lys Tyr Glu Pro Asn Gln Gln Phe Leu Glu Arg 
         275                280                285
Asp Gln Met Ser Met Glu Gly Phe Ser Arg Tyr Leu Gly Gly Glu Glu 
     290                295                300
Asn Gly Ile Leu Pro Leu Glu Ala Leu Asp Leu Ser Thr Asp Met Thr 
 305                310                315                320
Gln Pro Leu Ser Ala Tyr Phe Ile Asn Ser Ser His Asn Thr Tyr Leu 
                 325                330                335
Thr Ala Gly Gln Leu Ala Gly Thr Ser Ser Val Glu Met Tyr Arg Gln 
             340                345                350
Ala Leu Leu Trp Gly Cys Arg Cys Val Glu Leu Asp Val Trp Lys Gly 
         355                360                365
Arg Pro Pro Glu Glu Glu Pro Phe Ile Thr His Gly Phe Thr Met Thr 
     370                375                380
Thr Glu Val Pro Leu Arg Asp Val Leu Glu Ala Ile Ala Glu Thr Ala 
 385                390                395                400
Phe Lys Thr Ser Pro Tyr Pro Val Ile Leu Ser Phe Glu Asn His Val 
                 405                410                415
Asp Ser Ala Lys Gln Gln Ala Lys Met Ala Glu Tyr Cys Arg Ser Ile 
             420                425                430
Phe Gly Asp Ala Leu Leu Ile Glu Pro Leu Asp Lys Tyr Pro Leu Ala 
         435                440                445
Pro Gly Val Pro Leu Pro Ser Pro Gln Asp Leu Met Gly Arg Ile Leu 
     450                455                460
Val Lys Asn Lys Lys Arg His Arg Pro Ser Ala Gly Gly Pro Asp Ser 
 465                470                475                480
Ala Gly Arg Lys Arg Pro Leu Glu Gln Ser Asn Ser Ala Leu Ser Glu 
                 485                490                495
Ser Ser Ala Ala Thr Glu Pro Ser Ser Pro Gln Leu Gly Ser Pro Ser 
             500                505                510
Ser Asp Ser Cys Pro Gly Leu Ser Asn Gly Glu Glu Val Gly Leu Glu 
         515                520                525
Lys Pro Ser Leu Glu Pro Gln Lys Ser Leu Gly Asp Glu Gly Leu Asn 
     530                535                540
Arg Gly Pro Tyr Val Leu Gly Pro Ala Asp Arg Glu Asp Glu Glu Glu 
 545                550                555                560
Asp Glu Glu Glu Glu Glu Gln Thr Asp Pro Lys Lys Pro Thr Thr Asp 
                 565                570                575
Glu Gly Thr Ala Ser Ser Glu Val Asn Ala Thr Glu Glu Met Ser Thr 
             580                585                590
Leu Val Asn Tyr Ile Glu Pro Val Lys Phe Lys Ser Phe Glu Ala Ala 
         595                600                605
Arg Lys Arg Asn Lys Cys Phe Glu Met Ser Ser Phe Val Glu Thr Lys 
     610                615                620
Ala Met Glu Gln Leu Thr Lys Ser Pro Met Glu Phe Val Glu Tyr Asn 
 625                630                635                640
Lys Gln Gln Leu Ser Arg Ile Tyr Pro Lys Gly Thr Arg Val Asp Ser 
                 645                650                655
Ser Asn Tyr Met Pro Gln Leu Phe Trp Asn Val Gly Cys Gln Leu Val 
             660                665                670
Ala Leu Asn Phe Gln Thr Leu Asp Val Ala Met Gln Leu Asn Ala Gly 
         675                680                685
Val Phe Glu Tyr Asn Gly Arg Ser Gly Tyr Leu Leu Lys Pro Glu Phe 
     690                695                700
Met Arg Arg Pro Asp Lys Ser Phe Asp Pro Phe Thr Glu Val Ile Val 
 705                710                715                720
Asp Gly Ile Val Ala Asn Ala Leu Arg Val Lys Val Ile Ser Gly Gln 
                 725                730                735
Phe Leu Ser Asp Arg Lys Val Gly Ile Tyr Val Glu Val Asp Met Phe 
             740                745                750
Gly Leu Pro Val Asp Thr Arg Arg Lys Tyr Arg Thr Arg Thr Ser Gln 
         755                760                765
Gly Asn Ser Phe Asn Pro Val Trp Asp Glu Glu Pro Phe Asp Phe Pro 
     770                775                780
Lys Val Val Leu Pro Thr Leu Ala Ser Leu Arg Ile Ala Ala Phe Glu 
 785                790                795                800
Glu Gly Gly Lys Phe Val Gly His Arg Ile Leu Pro Val Ser Ala Ile 
                 805                810                815
Arg Ser Gly Tyr His Tyr Val Cys Leu Arg Asn Glu Ala Asn Gln Pro 
             820                825                830
Leu Cys Leu Pro Ala Leu Leu Ile Tyr Thr Glu Ala Ser Asp Tyr Ile 
         835                840                845
Pro Asp Asp His Gln Asp Tyr Ala Glu Ala Leu Ile Asn Pro Ile Lys 
     850                855                860
His Val Ser Leu Met Asp Gln Arg Ala Arg Gln Leu Ala Ala Leu Ile 
 865                870                875                880
Gly Glu Ser Glu Ala Gln Ala Gly Gln Glu Thr Cys Gln Asp Thr Gln 
                 885                890                895
Ser Gln Gln Leu Gly Ser Gln Pro Ser Ser Asn Pro Thr Pro Ser Pro 
             900                905                910
Leu Asp Ala Ser Pro Arg Arg Pro Pro Gly Pro Thr Thr Ser Pro Ala 
         915                920                925
Ser Thr Ser Leu Ser Ser Pro Gly Gln Arg Asp Asp Leu Ile Ala Ser 
     930                935                940
Ile Leu Ser Glu Val Ala Pro Thr Pro Leu Asp Glu Leu Arg Gly His 
 945                950                955                960
Lys Ala Leu Val Lys Leu Arg Ser Arg Gln Glu Arg Asp Leu Arg Glu 
                 965                970                975
Leu Arg Lys Lys His Gln Arg Lys Ala Val Thr Leu Thr Arg Arg Leu 
             980                985                990
Leu Asp Gly Leu Ala Gln Ala Gln Ala Glu Gly Arg Cys Arg Leu Arg 
         995                1000                1005
Pro Gly Ala Leu Gly Gly Ala Ala Asp Val Glu Asp Thr Lys Glu Gly 
     1010                1015                1020
Glu Asp Glu Ala Lys Arg Tyr Gln Glu Phe Gln Asn Arg Gln Val Gln 
 1025                1030                1035                1040
Ser Leu Leu Glu Leu Arg Glu Ala Gln Val Asp Ala Glu Ala Gln Arg 
                 1045                1050                1055
Arg Leu Glu His Leu Arg Gln Ala Leu Gln Arg Leu Arg Glu Val Val 
             1060                1065                1070
Leu Asp Ala Asn Thr Thr Gln Phe Lys Arg Leu Lys Glu Met Asn Glu 
         1075                1080                1085
Arg Glu Lys Lys Glu Leu Gln Lys Ile Leu Asp Arg Lys Arg His Asn 
     1090                1095                1100
Ser Ile Ser Glu Ala Lys Met Arg Asp Lys His Lys Lys Glu Ala Glu 
 1105                1110                1115                1120
Leu Thr Glu Ile Asn Arg Arg His Ile Thr Glu Ser Val Asn Ser Ile 
                 1125                1130                1135
Arg Arg Leu Glu Glu Ala Gln Lys Gln Arg His Asp Arg Leu Val Ala 
             1140                1145                1150
Gly Gln Gln Gln Val Leu Gln Gln Leu Ala Glu Glu Glu Pro Lys Leu 
         1155                1160                1165
Leu Ala Gln Leu Ala Gln Glu Cys Gln Glu Gln Arg Ala Arg Leu Pro 
     1170                1175                1180
Gln Glu Ile Arg Arg Ser Leu Leu Gly Glu Met Pro Glu Gly Leu Gly 
 1185                1190                1195                1200
Asp Gly Pro Leu Val Ala Cys Ala Ser Asn Gly His Ala Pro Gly Ser 
                 1205                1210                1215
Ser Gly His Leu Ser Gly Ala Asp Ser Glu Ser Gln Glu Glu Asn Thr 
             1220                1225                1230
Gln Leu 
         1235



<210> 4184
<211> 3800
<212> DNA
<213> Rattus norvegicus
<308> M99567
<400> 4184

gccgtggtg  agaccctgc  gcgcgggag  aaattcatc  aatgggacg  ggaggcctc  60
agtcggaac  tggtgaccc  gcgactgga  cccaatggc  tcttcttgt  ctggacagg  120
cccaacatg  aggtggaca  actggacat  agctccatc  gggacacaa  gacaggtcg  180
tatgcccgc  tgcccaagg  ccccaagat  cgagaggta  tgggctttg  gggtcctga  240
acccggctg  aggagaaac  gatgacagt  gtagcagga  cagatccag  aaacaccac  300
ttcttgaac  tcatggccg  gcaagatga  acagtcaag  tctggtcag  ggagttgtt  360
aagctggct  tgaacatac  ggctcagaa  gctccggaa  acgttcttc  gaaagcata  420
acgaaactg  agctgcagg  gaaccagga  ggacggatt  cagtcaaga  cattctgaa  480
atgttctcc  cggacaaga  gcgggtgga  actgcactg  tctgcggcc  caacttcaa  540
cggagtgag  ccattcggc  tgatgagtt  tccttggaa  tcttcgagc  gttcttgaa  600
aagctgttg  tgcgaccgg  tattgacaa  atcctgctg  agataggtg  caagggcaa  660
ccgtacctc  ctctggagc  gctcatgga  tttatcaac  agaagcaaa  agacccaag  720
ctcaacgag  tgctgtacc  accgcttcg  tcctcacag  ctcggctgc  cattgagaa  780
tatgagccg  acaaacagt  cctggagcg  gaccagatg  ctatggagg  tttcagccg  840
tatctggga  gggaggaga  tggcatcct  cccctggag  ccctggatc  gagcatgga  900
atgacgcag  cactgagcg  atacttcat  aattcttca  acaatacct  tctcactgc  960
ggccagctg  ctggaacat  gtcagtgga  atgtaccgc  aggcgctgc  gtggggctg  1020
cgttgtgtg  agctggatg  atggaaggg  cggccaccg  aggaagagc  cttcattac  1080
catggtttc  ccatgacca  tgaggtgcc  ttgcgtgat  tgttagagg  catcgccga  1140
acagccttc  agacctcac  ctaccctgt  attctctcc  tcgaaaacc  tgtggactc  1200
gcaaaacag  aggccaaga  ggcagagta  tgccgctct  tctttgggg  agcgctgct  1260
attgaccca  tggacaagt  cccgctgtc  gcgggcacc  cccttccta  tccacagga  1320
ctgatgggc  gtatcctgg  gaagaataa  aagcggcat  ggcccagca  aggtgtccc  1380
gacagctcc  tggccaagc  gcctctgga  cagagcaat  cagccctga  tgagagctc  1440
gctgccaca  agccctcct  accccagct  gggtccccc  gctctgaca  ctgccctgg  1500
ctaagcaat  gggaagagg  gggacttga  aagaccagc  tggagcctc  gaagtctct  1560
ggtgaggag  gcctcaacc  aggacctaa  gttctcatg  ctgaccgtg  ccgagagga  1620
gaggaggaa  atgaagaag  ggaggaaac  acggatcca  aaaagccca  caccgatga  1680
ggcacagcc  gcagtgagg  caacgccac  gaggagatg  cgacactcg  caattacgt  1740
gagcccgtc  agttcaagt  ctttgaggc  tctcgaaaa  ggaacaagt  ctttgagat  1800
tcgtccttt  tggagacca  ggcgatgga  cagctgacc  agagcccca  ggagttcgt  1860
gaatacaac  aacagcagc  tagtcgcat  taccccaag  ggacccgtg  ggactcctc  1920
aactacatg  ctcagctct  ctggaacgt  ggctgtcag  ttgttgccc  caacttcca  1980
accttggat  tgccaatgc  gctcaacgc  ggcgtgttt  agtacaacg  gcgcagtgg  2040
tacttgctc  agcctgagt  tatgcggcg  ccggacaag  cttttgacc  cttcactga  2100
gtcatcgta  atggcatag  ggccaacgc  ttgcgggtc  aggtgattt  ggggcagtt  2160
ctgtctgac  ggaaggtgg  catctatgt  gaggtggac  tgtttggtc  cccagttga  2220
acaagacgc  aatatcgca  acggacatc  caggggaac  cattcaacc  tgtgtggga  2280
gaagaaccc  ttgacttcc  caaggttgt  ctgcccacg  tggcctcac  tcgcattgc  2340
gcctttgag  agggtggca  atttgttgg  catcgtatc  tgcctgtct  tgctatccg  2400
tcaggatac  actacgtct  cctgcgaaa  gaggccaac  aaccgttgt  cctgcctgc  2460
ctgcttatc  acactgaag  ttctgacta  atcccagat  accaccagg  ctatgcgga  2520
gccttgatc  accccatca  gcacgtcag  ctaatggac  agcgggcca  gcaactggc  2580
gctctcatt  gggagagtg  ggctcaggc  agtacagaa  tgtgtcagg  gaccccgtc  2640
caacagcaa  gctcacagc  ctcctccaa  cccgtacct  acccactgg  tgactcacc  2700
cgatggccc  caggtccta  cacctcccc  actagcacc  ccctcagta  cccagggca  2760
cgagatgat  tgatcgcca  catcctttc  gaggtgacc  caacacccc  agaggagct  2820
cgaagccac  aggctatgg  gaagctccg  agccggcag  atcgagacc  gagggaact  2880
cataaaaaa  accagcgca  ggctgtggc  ctcacccgc  gccttctgg  tggcctggc  2940
caggccagg  ctgagggga  gtgccggcc  tcctccagc  ccctgagca  ggccaccaa  3000
gtggaagac  tgaaggagg  agaaaaaga  gcagccaga  agtatcgag  gttccagaa  3060
cgacaagta  agagcctgc  ggagctgag  gaggcccag  cagatgcag  gacagaacg  3120
aggctggag  atctgaaac  ggctcagca  cggctcagg  aggttgtcc  ggacgcaca  3180
acgactcag  tcaagaggc  gaaggagtt  aatgaaagg  agaagaagg  gcttcagaa  3240
atcctggac  ggaagcgca  caacagcat  tcagaggcc  agacaaggg  gaaacacaa  3300
aaggaggtg  aactgacag  gatcaatcg  aggcacatc  ctgagtcag  gaactccat  3360
aggaggctg  aagaggccc  gaagcagcg  cacgaacgc  tcttggcag  gcaacagca  3420
gtcctccag  agctagtgg  agaggagcc  aagctggtg  cccagctga  ccaggagtg  3480
caggaacag  gagagaggc  gccccagga  atccgtcgg  gcctgctgg  cgagacatc  3540
gagggattg  gggatggcc  cctggtggc  tgtgccagc  atggtcatg  agctgggag  3600
ggtgggcac  agtccggcg  tgactcgga  agccaggag  aaaacaccc  gctttgaac  3660
ggcggagca  gaggtggcc  caagactgg  tgggcactg  gctgtgggt  gaagacact  3720
atactttgg  tttttttta  ccttttatc  ttagaaatt  tattttttt  aaatccgag  3780
caaatcgga  ttcgtgtaca  3800



<210> 4185
<211> 3705
<212> DNA
<213> Homo sapiens
<308> NM_000932
<400> 4185

atggcgggc  cccagcccg  cgtccacgc  ctgcagttg  agccgccca  cgtggtgga  60
accctgcgg  gcgggagta  gttcatcaa  tgggacgag  agacctcca  tcggaacct  120
gtgaccctg  gtgtggacc  caatggctt  ttcttgtac  ggacgggcc  caacatgga  180
gtggacaca  tggacatca  ttccatcag  gacacacgg  caggccggt  cgcccgcct  240
cccaaggac  ccaagatcc  ggaagttct  ggctttggg  gtcccgatg  ccggctgga  300
gagaagctg  tgacggtgg  gtctgggcc  gacccggtg  acacagtgt  cttgaactt  360
atggccgtg  aggatgaca  agccaaggt  tggtctgag  agctattca  gctggctat  420
aacatcctg  ctcagaacg  ctcccggaa  accttcctg  gcaaagcat  cacgaagct  480
aagctgcag  tgaaccagg  tggtcggat  cccgtcaag  acatcctga  gatgttctc  540
gcagacaag  agcgggtgg  gactgcgct  gaatcctgt  gcctcaaat  caaccggag  600
gagtccatc  ggcctgatg  gttttcctt  gaaatcttt  agcggttcc  gaacaagct  660
tgtctgcgg  cggacattg  caagatcct  ctggagata  gcgccaagg  caagccata  720
ctgacgctg  agcagctca  ggacttcat  aaccagaag  aacgcgacc  gagactcaa  780
gaagtgctg  acccgcccc  gcggccctc  caggcccgg  tgctcatcg  aaagtatga  840
cccaaccag  agtttctgg  gcgagacca  atgtccatg  agggcttta  ccgctacct  900
ggaggcgag  agaatggca  cctgcccct  gaagccctg  atctgagca  ggacatgac  960
cagccactg  gtgcctact  catcaactc  tcgcataac  cctatctca  tgcggggca  1020
ctggctggg  cctcgtcgg  ggagatgta  cgccaggca  tactatggg  ctgccgctg  1080
gtggagctg  acgtgtgga  gggacggcc  cctgaggag  aacccttca  tacccacgg  1140
ttcaccatg  ccacagagg  gcctctgcg  gacgtgctg  aggccattg  cgagactgc  1200
ttcaagacc  cgccctacc  cgtcatcct  tccttcgag  accatgtgg  ctcggcaaa  1260
caacaggca  agatggctg  gtactgccg  tccatcttt  gagacgcgc  actcatcga  1320
cctctggac  agtacccgc  ggccccagg  gttcccctg  ccagccccc  ggacctgat  1380
ggccgtatc  tggtgaaga  caagaagcg  caccgaccc  gcgcaggtg  cccagacag  1440
gccgggcgc  agcggcccc  ggagcagag  aattctgcc  tgagcgaga  ctccgcggc  1500
accgagccc  cctccccgc  gctggggtc  cccagctct  acagctgcc  aggcctgag  1560
aatggggag  aggtagggc  tgagaagcc  agcctggag  ctcagaagt  tctgggtga  1620
gagggcctg  accgaggcc  ctatgttct  ggacctgct  accgtgagg  tgaggagga  1680
gatgaggaa  aggaggaac  gacagaccc  aaaaagcca  ctacagatg  gggcacagc  1740
agcagcgag  tgaatgcca  tgaggagat  tccacgctt  tcaactaca  cgaacctgt  1800
aagttcaag  cctttgagg  tgctcgaaa  aggaacaaa  gcttcgaga  gtcgtcctt  1860
gtggagacc  aggccatgg  gcaactgac  aagagcccc  tggagtttg  ggaatacaa  1920
aagcagcag  tcagccgca  ctaccccaa  ggcacccgc  tggactcct  caactacat  1980
ccccagctc  tctggaacg  agggtgcca  cttgttgcg  tcaacttcc  gaccctcga  2040
gtggcgatg  agctcaacg  gggcgtttt  gagtacaac  ggcgcagcg  gtacctgct  2100
aagccggag  tcatgcggc  gccggacaa  tccttcgac  ccttcactg  ggtcatcgt  2160
gatggcatc  tggccaatg  cttgcgggt  aaggtgatc  cagggcagt  cctgtccga  2220
aggaaggtg  gcatctacg  ggaggtgga  atgtttggc  tccctgttg  tacgcggcg  2280
aagtaccgc  cccggacct  tcaggggaa  tcgttcaac  ccgtgtggg  cgaagagcc  2340
ttcgacttc  ccaaggtgg  gctgcccac  ctggcttca  ttcgcattg  agcctttga  2400
gaggggggt  aattcgtag  gcaccggat  ctgcctgtc  ctgccatcc  ctccggata  2460
cactacgtc  gcctgcgga  cgaggccaa  caaccgctg  gcctgccgg  cctgctcat  2520
tacaccgaa  cctcggact  cattcctga  gaccaccag  actatgcgg  ggccctgat  2580
aaccccatt  agcacgtca  cctgatgga  cagagggcc  ggcagctgg  cgccctcat  2640
ggggagagt  aggctcagg  tggccaaga  acgtgccag  acacccagt  tcagcagct  2700
gggtctcag  cgtcctcaa  ccccacccc  agcccactg  atgcctccc  ccgccggcc  2760
cctggcccc  ccacctccc  tgccagcac  tccctcagc  gcccagggc  gcgtgatga  2820
ctcatcgcc  gcatcctct  agaggtggc  cccaccccg  tggatgagc  ccgaggtca  2880
aaggctctg  tcaagctcc  gagccggca  gagcgagac  tgcgggagc  gcgcaagaa  2940
catcagcgg  aggcagtca  cctcacccg  cgcctgctg  atggcctgg  tcaggcaca  3000
gctgagggc  ggtgccggc  gcggccagg  gccctaggt  gggccgctg  tgtggagga  3060
acgaaggag  gggaggacg  ggcaaagcg  tatcaggag  tccagaaca  acaggtgca  3120
agcctgctg  agctgcggg  ggcccaggt  gacgcagag  cccagcgga  gctggaaca  3180
ctgagacag  ctctgcagc  gctcaggga  gtcgtcctt  atgcaaaca  aactcagtt  3240
aagaggctg  aagagatga  cgagaggga  aagaaggag  tgcagaaga  cctggacag  3300
aagcgccat  acagcatct  ggaggccaa  atgagggac  agcataaga  ggaggcgga  3360
ctgacggag  ttaaccgtc  gcacatcac  gagtcagtc  actccatcc  tcggctgga  3420
gaggcccag  agcagcggc  tgaccgtct  gtggctggg  agcagcagg  cctgcaaca  3480
ctggcagaa  aggagccca  gctgctggc  cagctggcc  aggagtgtc  ggagcagcg  3540
gcgaggctc  cccaggaga  ccgccggag  ctgctgggc  agatgccgg  ggggctggg  3600
gacgggcct  tggtggcct  tgccagcaa  ggtcacgca  ccgggagca  cgggcacct  3660
tcgggcgct  actcggaga  ccaggagga  aacacgcag  tctga  3705



<210> 4186
<211> 1234
<212> PRT
<213> Homo sapiens
<308> Q01970
<400> 4186

Met Ala Gly Ala Gln Pro Gly Val His Ala Leu Gln Leu Glu Pro Pro 
  1               5                  10                  15
Thr Val Val Glu Thr Leu Arg Arg Gly Ser Lys Phe Ile Lys Trp Asp 
             20                  25                  30
Glu Glu Thr Ser Ser Arg Asn Leu Val Thr Leu Arg Val Asp Pro Asn 
         35                  40                  45
Gly Phe Phe Leu Tyr Trp Thr Gly Pro Asn Met Glu Val Asp Thr Leu 
     50                  55                  60
Asp Ile Ser Ser Ile Arg Asp Thr Arg Thr Gly Arg Tyr Ala Arg Leu 
 65                  70                  75                  80
Pro Lys Asp Pro Lys Ile Arg Glu Val Leu Gly Phe Gly Gly Pro Asp 
                 85                  90                  95
Ala Arg Leu Glu Glu Lys Leu Met Thr Val Val Ser Gly Pro Asp Pro 
             100                105                110
Val Asn Thr Val Phe Leu Asn Phe Met Ala Val Gln Asp Asp Thr Ala 
         115                120                125
Lys Val Trp Ser Glu Glu Leu Phe Lys Leu Ala Met Asn Ile Leu Ala 
     130                135                140
Gln Asn Ala Ser Arg Asn Thr Phe Leu Arg Lys Ala Tyr Thr Lys Leu 
 145                150                155                160
Lys Leu Gln Val Asn Gln Asp Gly Arg Ile Pro Val Lys Asn Ile Leu 
                 165                170                175
Lys Met Phe Ser Ala Asp Lys Lys Arg Val Glu Thr Ala Leu Glu Ser 
             180                185                190
Cys Gly Leu Lys Phe Asn Arg Ser Glu Ser Ile Arg Pro Asp Glu Phe 
         195                200                205
Ser Leu Glu Ile Phe Glu Arg Phe Leu Asn Lys Leu Cys Leu Arg Pro 
     210                215                220
Asp Ile Asp Lys Ile Leu Leu Glu Ile Gly Ala Lys Gly Lys Pro Tyr 
 225                230                235                240
Leu Thr Leu Glu Gln Leu Met Asp Phe Ile Asn Gln Lys Gln Arg Asp 
                 245                250                255
Pro Arg Leu Asn Glu Val Leu Tyr Pro Pro Leu Arg Pro Ser Gln Ala 
             260                265                270
Arg Leu Leu Ile Glu Lys Tyr Glu Pro Asn Gln Gln Phe Leu Glu Arg 
         275                280                285
Asp Gln Met Ser Met Glu Gly Phe Ser Arg Tyr Leu Gly Gly Glu Glu 
     290                295                300
Asn Gly Ile Leu Pro Leu Glu Ala Leu Asp Leu Ser Thr Asp Met Thr 
 305                310                315                320
Gln Pro Leu Ser Ala Tyr Phe Ile Asn Ser Ser His Asn Thr Tyr Leu 
                 325                330                335
Thr Ala Gly Gln Leu Ala Gly Thr Ser Ser Val Glu Met Tyr Arg Gln 
             340                345                350
Ala Leu Leu Trp Gly Cys Arg Cys Val Glu Leu Asp Val Trp Lys Gly 
         355                360                365
Arg Pro Pro Glu Glu Glu Pro Phe Ile Thr His Gly Phe Thr Met Thr 
     370                375                380
Thr Glu Val Pro Leu Arg Asp Val Leu Glu Ala Ile Ala Glu Thr Ala 
 385                390                395                400
Phe Lys Thr Ser Pro Tyr Pro Val Ile Leu Ser Phe Glu Asn His Val 
                 405                410                415
Asp Ser Ala Lys Gln Gln Ala Lys Met Ala Glu Tyr Cys Arg Ser Ile 
             420                425                430
Phe Gly Asp Ala Leu Leu Ile Glu Pro Leu Asp Lys Tyr Pro Leu Ala 
         435                440                445
Pro Gly Val Pro Leu Pro Ser Pro Gln Asp Leu Met Gly Arg Ile Leu 
     450                455                460
Val Lys Asn Lys Lys Arg His Arg Pro Ser Ala Gly Gly Pro Asp Ser 
 465                470                475                480
Ala Gly Arg Lys Arg Pro Leu Glu Gln Ser Asn Ser Ala Leu Ser Glu 
                 485                490                495
Ser Ser Ala Ala Thr Glu Pro Ser Ser Pro Gln Leu Gly Ser Pro Ser 
             500                505                510
Ser Asp Ser Cys Pro Gly Leu Ser Asn Gly Glu Glu Val Gly Leu Glu 
         515                520                525
Lys Pro Ser Leu Glu Pro Gln Lys Ser Leu Gly Asp Glu Gly Leu Asn 
     530                535                540
Arg Gly Pro Tyr Val Leu Gly Pro Ala Asp Arg Glu Asp Glu Glu Glu 
 545                550                555                560
Asp Glu Glu Glu Glu Glu Gln Thr Asp Pro Lys Lys Pro Thr Thr Asp 
                 565                570                575
Glu Gly Thr Ala Ser Ser Glu Val Asn Ala Thr Glu Glu Met Ser Thr 
             580                585                590
Leu Val Asn Tyr Ile Glu Pro Val Lys Phe Lys Ser Phe Glu Ala Ala 
         595                600                605
Arg Lys Arg Asn Lys Cys Phe Glu Met Ser Ser Phe Val Glu Thr Lys 
     610                615                620
Ala Met Glu Gln Leu Thr Lys Ser Pro Met Glu Phe Val Glu Tyr Asn 
 625                630                635                640
Lys Gln Gln Leu Ser Arg Ile Tyr Pro Lys Gly Thr Arg Val Asp Ser 
                 645                650                655
Ser Asn Tyr Met Pro Gln Leu Phe Trp Asn Val Gly Cys Gln Leu Val 
             660                665                670
Ala Leu Asn Phe Gln Thr Leu Asp Val Ala Met Gln Leu Asn Ala Gly 
         675                680                685
Val Phe Glu Tyr Asn Gly Arg Ser Gly Tyr Leu Leu Lys Pro Glu Phe 
     690                695                700
Met Arg Arg Pro Asp Lys Ser Phe Asp Pro Phe Thr Glu Val Ile Val 
 705                710                715                720
Asp Gly Ile Val Ala Asn Ala Leu Arg Val Lys Val Ile Ser Gly Gln 
                 725                730                735
Phe Leu Ser Asp Arg Lys Val Gly Ile Tyr Val Glu Val Asp Met Phe 
             740                745                750
Gly Leu Pro Val Asp Thr Arg Arg Lys Tyr Arg Thr Arg Thr Ser Gln 
         755                760                765
Gly Asn Ser Phe Asn Pro Val Trp Asp Glu Glu Pro Phe Asp Phe Pro 
     770                775                780
Lys Val Val Leu Pro Thr Leu Ala Ser Leu Arg Ile Ala Ala Phe Glu 
 785                790                795                800
Glu Gly Gly Lys Phe Val Gly His Arg Ile Leu Pro Val Ser Ala Ile 
                 805                810                815
Arg Ser Gly Tyr His Tyr Val Cys Leu Arg Asn Glu Ala Asn Gln Pro 
             820                825                830
Leu Cys Leu Pro Ala Leu Leu Ile Tyr Thr Glu Ala Ser Asp Tyr Ile 
         835                840                845
Pro Asp Asp His Gln Asp Tyr Ala Glu Ala Leu Ile Asn Pro Ile Lys 
     850                855                860
His Val Ser Leu Met Asp Gln Arg Ala Arg Gln Leu Ala Ala Leu Ile 
 865                870                875                880
Gly Glu Ser Glu Ala Gln Ala Gly Gln Glu Thr Cys Gln Asp Thr Gln 
                 885                890                895
Ser Gln Gln Leu Gly Ser Gln Pro Ser Ser Asn Pro Thr Pro Ser Pro 
             900                905                910
Leu Asp Ala Ser Pro Arg Arg Pro Pro Gly Pro Thr Thr Ser Pro Ala 
         915                920                925
Ser Thr Ser Leu Ser Ser Pro Gly Gln Arg Asp Asp Leu Ile Ala Ser 
     930                935                940
Ile Leu Ser Glu Val Ala Pro Thr Pro Leu Asp Glu Leu Arg Gly His 
 945                950                955                960
Lys Ala Leu Val Lys Leu Arg Ser Arg Gln Glu Arg Asp Leu Arg Glu 
                 965                970                975
Leu Arg Lys Lys His Gln Arg Lys Ala Val Thr Leu Thr Arg Arg Leu 
             980                985                990
Leu Asp Gly Leu Ala Gln Ala Gln Ala Glu Gly Arg Cys Arg Leu Arg 
         995                1000                1005
Pro Gly Ala Leu Gly Gly Ala Ala Asp Val Glu Asp Thr Lys Glu Gly 
     1010                1015                1020
Glu Asp Glu Ala Lys Arg Tyr Gln Glu Phe Gln Asn Arg Gln Val Gln 
 1025                1030                1035                1040
Ser Leu Leu Glu Leu Arg Glu Ala Gln Val Asp Ala Glu Ala Gln Arg 
                 1045                1050                1055
Arg Leu Glu His Leu Arg Gln Ala Leu Gln Arg Leu Arg Glu Val Val 
             1060                1065                1070
Leu Asp Ala Asn Thr Thr Gln Phe Lys Arg Leu Lys Glu Met Asn Glu 
         1075                1080                1085
Arg Glu Lys Lys Glu Leu Gln Lys Ile Leu Asp Arg Lys Arg His Asn 
     1090                1095                1100
Ser Ile Ser Glu Ala Lys Met Arg Asp Lys His Lys Lys Glu Ala Glu 
 1105                1110                1115                1120
Leu Thr Glu Ile Asn Arg Arg His Ile Thr Glu Ser Val Asn Ser Ile 
                 1125                1130                1135
Arg Arg Leu Glu Glu Ala Gln Lys Gln Arg His Asp Arg Leu Val Ala 
             1140                1145                1150
Gly Gln Gln Gln Val Leu Gln Gln Leu Ala Glu Glu Glu Pro Lys Leu 
         1155                1160                1165
Leu Ala Gln Leu Ala Gln Glu Cys Gln Glu Gln Arg Ala Arg Leu Pro 
     1170                1175                1180
Gln Glu Ile Arg Arg Ser Leu Leu Gly Glu Met Pro Glu Gly Leu Gly 
 1185                1190                1195                1200
Asp Gly Pro Leu Val Ala Cys Ala Ser Asn Gly His Ala Pro Gly Ser 
                 1205                1210                1215
Ser Gly His Leu Ser Gly Ala Asp Ser Glu Ser Gln Glu Glu Asn Thr 
             1220                1225                1230
Gln Leu 
         1235



<210> 4187
<211> 3800
<212> DNA
<213> Rattus norvegicus
<308> M99567
<400> 4187

gccgtggtg  agaccctgc  gcgcgggag  aaattcatc  aatgggacg  ggaggcctc  60
agtcggaac  tggtgaccc  gcgactgga  cccaatggc  tcttcttgt  ctggacagg  120
cccaacatg  aggtggaca  actggacat  agctccatc  gggacacaa  gacaggtcg  180
tatgcccgc  tgcccaagg  ccccaagat  cgagaggta  tgggctttg  gggtcctga  240
acccggctg  aggagaaac  gatgacagt  gtagcagga  cagatccag  aaacaccac  300
ttcttgaac  tcatggccg  gcaagatga  acagtcaag  tctggtcag  ggagttgtt  360
aagctggct  tgaacatac  ggctcagaa  gctccggaa  acgttcttc  gaaagcata  420
acgaaactg  agctgcagg  gaaccagga  ggacggatt  cagtcaaga  cattctgaa  480
atgttctcc  cggacaaga  gcgggtgga  actgcactg  tctgcggcc  caacttcaa  540
cggagtgag  ccattcggc  tgatgagtt  tccttggaa  tcttcgagc  gttcttgaa  600
aagctgttg  tgcgaccgg  tattgacaa  atcctgctg  agataggtg  caagggcaa  660
ccgtacctc  ctctggagc  gctcatgga  tttatcaac  agaagcaaa  agacccaag  720
ctcaacgag  tgctgtacc  accgcttcg  tcctcacag  ctcggctgc  cattgagaa  780
tatgagccg  acaaacagt  cctggagcg  gaccagatg  ctatggagg  tttcagccg  840
tatctggga  gggaggaga  tggcatcct  cccctggag  ccctggatc  gagcatgga  900
atgacgcag  cactgagcg  atacttcat  aattcttca  acaatacct  tctcactgc  960
ggccagctg  ctggaacat  gtcagtgga  atgtaccgc  aggcgctgc  gtggggctg  1020
cgttgtgtg  agctggatg  atggaaggg  cggccaccg  aggaagagc  cttcattac  1080
catggtttc  ccatgacca  tgaggtgcc  ttgcgtgat  tgttagagg  catcgccga  1140
acagccttc  agacctcac  ctaccctgt  attctctcc  tcgaaaacc  tgtggactc  1200
gcaaaacag  aggccaaga  ggcagagta  tgccgctct  tctttgggg  agcgctgct  1260
attgaccca  tggacaagt  cccgctgtc  gcgggcacc  cccttccta  tccacagga  1320
ctgatgggc  gtatcctgg  gaagaataa  aagcggcat  ggcccagca  aggtgtccc  1380
gacagctcc  tggccaagc  gcctctgga  cagagcaat  cagccctga  tgagagctc  1440
gctgccaca  agccctcct  accccagct  gggtccccc  gctctgaca  ctgccctgg  1500
ctaagcaat  gggaagagg  gggacttga  aagaccagc  tggagcctc  gaagtctct  1560
ggtgaggag  gcctcaacc  aggacctaa  gttctcatg  ctgaccgtg  ccgagagga  1620
gaggaggaa  atgaagaag  ggaggaaac  acggatcca  aaaagccca  caccgatga  1680
ggcacagcc  gcagtgagg  caacgccac  gaggagatg  cgacactcg  caattacgt  1740
gagcccgtc  agttcaagt  ctttgaggc  tctcgaaaa  ggaacaagt  ctttgagat  1800
tcgtccttt  tggagacca  ggcgatgga  cagctgacc  agagcccca  ggagttcgt  1860
gaatacaac  aacagcagc  tagtcgcat  taccccaag  ggacccgtg  ggactcctc  1920
aactacatg  ctcagctct  ctggaacgt  ggctgtcag  ttgttgccc  caacttcca  1980
accttggat  tgccaatgc  gctcaacgc  ggcgtgttt  agtacaacg  gcgcagtgg  2040
tacttgctc  agcctgagt  tatgcggcg  ccggacaag  cttttgacc  cttcactga  2100
gtcatcgta  atggcatag  ggccaacgc  ttgcgggtc  aggtgattt  ggggcagtt  2160
ctgtctgac  ggaaggtgg  catctatgt  gaggtggac  tgtttggtc  cccagttga  2220
acaagacgc  aatatcgca  acggacatc  caggggaac  cattcaacc  tgtgtggga  2280
gaagaaccc  ttgacttcc  caaggttgt  ctgcccacg  tggcctcac  tcgcattgc  2340
gcctttgag  agggtggca  atttgttgg  catcgtatc  tgcctgtct  tgctatccg  2400
tcaggatac  actacgtct  cctgcgaaa  gaggccaac  aaccgttgt  cctgcctgc  2460
ctgcttatc  acactgaag  ttctgacta  atcccagat  accaccagg  ctatgcgga  2520
gccttgatc  accccatca  gcacgtcag  ctaatggac  agcgggcca  gcaactggc  2580
gctctcatt  gggagagtg  ggctcaggc  agtacagaa  tgtgtcagg  gaccccgtc  2640
caacagcaa  gctcacagc  ctcctccaa  cccgtacct  acccactgg  tgactcacc  2700
cgatggccc  caggtccta  cacctcccc  actagcacc  ccctcagta  cccagggca  2760
cgagatgat  tgatcgcca  catcctttc  gaggtgacc  caacacccc  agaggagct  2820
cgaagccac  aggctatgg  gaagctccg  agccggcag  atcgagacc  gagggaact  2880
cataaaaaa  accagcgca  ggctgtggc  ctcacccgc  gccttctgg  tggcctggc  2940
caggccagg  ctgagggga  gtgccggcc  tcctccagc  ccctgagca  ggccaccaa  3000
gtggaagac  tgaaggagg  agaaaaaga  gcagccaga  agtatcgag  gttccagaa  3060
cgacaagta  agagcctgc  ggagctgag  gaggcccag  cagatgcag  gacagaacg  3120
aggctggag  atctgaaac  ggctcagca  cggctcagg  aggttgtcc  ggacgcaca  3180
acgactcag  tcaagaggc  gaaggagtt  aatgaaagg  agaagaagg  gcttcagaa  3240
atcctggac  ggaagcgca  caacagcat  tcagaggcc  agacaaggg  gaaacacaa  3300
aaggaggtg  aactgacag  gatcaatcg  aggcacatc  ctgagtcag  gaactccat  3360
aggaggctg  aagaggccc  gaagcagcg  cacgaacgc  tcttggcag  gcaacagca  3420
gtcctccag  agctagtgg  agaggagcc  aagctggtg  cccagctga  ccaggagtg  3480
caggaacag  gagagaggc  gccccagga  atccgtcgg  gcctgctgg  cgagacatc  3540
gagggattg  gggatggcc  cctggtggc  tgtgccagc  atggtcatg  agctgggag  3600
ggtgggcac  agtccggcg  tgactcgga  agccaggag  aaaacaccc  gctttgaac  3660
ggcggagca  gaggtggcc  caagactgg  tgggcactg  gctgtgggt  gaagacact  3720
atactttgg  tttttttta  ccttttatc  ttagaaatt  tattttttt  aaatccgag  3780
caaatcgga  ttcgtgtaca  3800



<210> 4188
<211> 3705
<212> DNA
<213> Homo sapiens
<308> NM_000932
<400> 4188

atggcgggc  cccagcccg  cgtccacgc  ctgcagttg  agccgccca  cgtggtgga  60
accctgcgg  gcgggagta  gttcatcaa  tgggacgag  agacctcca  tcggaacct  120
gtgaccctg  gtgtggacc  caatggctt  ttcttgtac  ggacgggcc  caacatgga  180
gtggacaca  tggacatca  ttccatcag  gacacacgg  caggccggt  cgcccgcct  240
cccaaggac  ccaagatcc  ggaagttct  ggctttggg  gtcccgatg  ccggctgga  300
gagaagctg  tgacggtgg  gtctgggcc  gacccggtg  acacagtgt  cttgaactt  360
atggccgtg  aggatgaca  agccaaggt  tggtctgag  agctattca  gctggctat  420
aacatcctg  ctcagaacg  ctcccggaa  accttcctg  gcaaagcat  cacgaagct  480
aagctgcag  tgaaccagg  tggtcggat  cccgtcaag  acatcctga  gatgttctc  540
gcagacaag  agcgggtgg  gactgcgct  gaatcctgt  gcctcaaat  caaccggag  600
gagtccatc  ggcctgatg  gttttcctt  gaaatcttt  agcggttcc  gaacaagct  660
tgtctgcgg  cggacattg  caagatcct  ctggagata  gcgccaagg  caagccata  720
ctgacgctg  agcagctca  ggacttcat  aaccagaag  aacgcgacc  gagactcaa  780
gaagtgctg  acccgcccc  gcggccctc  caggcccgg  tgctcatcg  aaagtatga  840
cccaaccag  agtttctgg  gcgagacca  atgtccatg  agggcttta  ccgctacct  900
ggaggcgag  agaatggca  cctgcccct  gaagccctg  atctgagca  ggacatgac  960
cagccactg  gtgcctact  catcaactc  tcgcataac  cctatctca  tgcggggca  1020
ctggctggg  cctcgtcgg  ggagatgta  cgccaggca  tactatggg  ctgccgctg  1080
gtggagctg  acgtgtgga  gggacggcc  cctgaggag  aacccttca  tacccacgg  1140
ttcaccatg  ccacagagg  gcctctgcg  gacgtgctg  aggccattg  cgagactgc  1200
ttcaagacc  cgccctacc  cgtcatcct  tccttcgag  accatgtgg  ctcggcaaa  1260
caacaggca  agatggctg  gtactgccg  tccatcttt  gagacgcgc  actcatcga  1320
cctctggac  agtacccgc  ggccccagg  gttcccctg  ccagccccc  ggacctgat  1380
ggccgtatc  tggtgaaga  caagaagcg  caccgaccc  gcgcaggtg  cccagacag  1440
gccgggcgc  agcggcccc  ggagcagag  aattctgcc  tgagcgaga  ctccgcggc  1500
accgagccc  cctccccgc  gctggggtc  cccagctct  acagctgcc  aggcctgag  1560
aatggggag  aggtagggc  tgagaagcc  agcctggag  ctcagaagt  tctgggtga  1620
gagggcctg  accgaggcc  ctatgttct  ggacctgct  accgtgagg  tgaggagga  1680
gatgaggaa  aggaggaac  gacagaccc  aaaaagcca  ctacagatg  gggcacagc  1740
agcagcgag  tgaatgcca  tgaggagat  tccacgctt  tcaactaca  cgaacctgt  1800
aagttcaag  cctttgagg  tgctcgaaa  aggaacaaa  gcttcgaga  gtcgtcctt  1860
gtggagacc  aggccatgg  gcaactgac  aagagcccc  tggagtttg  ggaatacaa  1920
aagcagcag  tcagccgca  ctaccccaa  ggcacccgc  tggactcct  caactacat  1980
ccccagctc  tctggaacg  agggtgcca  cttgttgcg  tcaacttcc  gaccctcga  2040
gtggcgatg  agctcaacg  gggcgtttt  gagtacaac  ggcgcagcg  gtacctgct  2100
aagccggag  tcatgcggc  gccggacaa  tccttcgac  ccttcactg  ggtcatcgt  2160
gatggcatc  tggccaatg  cttgcgggt  aaggtgatc  cagggcagt  cctgtccga  2220
aggaaggtg  gcatctacg  ggaggtgga  atgtttggc  tccctgttg  tacgcggcg  2280
aagtaccgc  cccggacct  tcaggggaa  tcgttcaac  ccgtgtggg  cgaagagcc  2340
ttcgacttc  ccaaggtgg  gctgcccac  ctggcttca  ttcgcattg  agcctttga  2400
gaggggggt  aattcgtag  gcaccggat  ctgcctgtc  ctgccatcc  ctccggata  2460
cactacgtc  gcctgcgga  cgaggccaa  caaccgctg  gcctgccgg  cctgctcat  2520
tacaccgaa  cctcggact  cattcctga  gaccaccag  actatgcgg  ggccctgat  2580
aaccccatt  agcacgtca  cctgatgga  cagagggcc  ggcagctgg  cgccctcat  2640
ggggagagt  aggctcagg  tggccaaga  acgtgccag  acacccagt  tcagcagct  2700
gggtctcag  cgtcctcaa  ccccacccc  agcccactg  atgcctccc  ccgccggcc  2760
cctggcccc  ccacctccc  tgccagcac  tccctcagc  gcccagggc  gcgtgatga  2820
ctcatcgcc  gcatcctct  agaggtggc  cccaccccg  tggatgagc  ccgaggtca  2880
aaggctctg  tcaagctcc  gagccggca  gagcgagac  tgcgggagc  gcgcaagaa  2940
catcagcgg  aggcagtca  cctcacccg  cgcctgctg  atggcctgg  tcaggcaca  3000
gctgagggc  ggtgccggc  gcggccagg  gccctaggt  gggccgctg  tgtggagga  3060
acgaaggag  gggaggacg  ggcaaagcg  tatcaggag  tccagaaca  acaggtgca  3120
agcctgctg  agctgcggg  ggcccaggt  gacgcagag  cccagcgga  gctggaaca  3180
ctgagacag  ctctgcagc  gctcaggga  gtcgtcctt  atgcaaaca  aactcagtt  3240
aagaggctg  aagagatga  cgagaggga  aagaaggag  tgcagaaga  cctggacag  3300
aagcgccat  acagcatct  ggaggccaa  atgagggac  agcataaga  ggaggcgga  3360
ctgacggag  ttaaccgtc  gcacatcac  gagtcagtc  actccatcc  tcggctgga  3420
gaggcccag  agcagcggc  tgaccgtct  gtggctggg  agcagcagg  cctgcaaca  3480
ctggcagaa  aggagccca  gctgctggc  cagctggcc  aggagtgtc  ggagcagcg  3540
gcgaggctc  cccaggaga  ccgccggag  ctgctgggc  agatgccgg  ggggctggg  3600
gacgggcct  tggtggcct  tgccagcaa  ggtcacgca  ccgggagca  cgggcacct  3660
tcgggcgct  actcggaga  ccaggagga  aacacgcag  tctga  3705



<210> 4189
<211> 1234
<212> PRT
<213> Homo sapiens
<308> Q01970
<400> 4189

Met Ala Gly Ala Gln Pro Gly Val His Ala Leu Gln Leu Glu Pro Pro 
  1               5                  10                  15
Thr Val Val Glu Thr Leu Arg Arg Gly Ser Lys Phe Ile Lys Trp Asp 
             20                  25                  30
Glu Glu Thr Ser Ser Arg Asn Leu Val Thr Leu Arg Val Asp Pro Asn 
         35                  40                  45
Gly Phe Phe Leu Tyr Trp Thr Gly Pro Asn Met Glu Val Asp Thr Leu 
     50                  55                  60
Asp Ile Ser Ser Ile Arg Asp Thr Arg Thr Gly Arg Tyr Ala Arg Leu 
 65                  70                  75                  80
Pro Lys Asp Pro Lys Ile Arg Glu Val Leu Gly Phe Gly Gly Pro Asp 
                 85                  90                  95
Ala Arg Leu Glu Glu Lys Leu Met Thr Val Val Ser Gly Pro Asp Pro 
             100                105                110
Val Asn Thr Val Phe Leu Asn Phe Met Ala Val Gln Asp Asp Thr Ala 
         115                120                125
Lys Val Trp Ser Glu Glu Leu Phe Lys Leu Ala Met Asn Ile Leu Ala 
     130                135                140
Gln Asn Ala Ser Arg Asn Thr Phe Leu Arg Lys Ala Tyr Thr Lys Leu 
 145                150                155                160
Lys Leu Gln Val Asn Gln Asp Gly Arg Ile Pro Val Lys Asn Ile Leu 
                 165                170                175
Lys Met Phe Ser Ala Asp Lys Lys Arg Val Glu Thr Ala Leu Glu Ser 
             180                185                190
Cys Gly Leu Lys Phe Asn Arg Ser Glu Ser Ile Arg Pro Asp Glu Phe 
         195                200                205
Ser Leu Glu Ile Phe Glu Arg Phe Leu Asn Lys Leu Cys Leu Arg Pro 
     210                215                220
Asp Ile Asp Lys Ile Leu Leu Glu Ile Gly Ala Lys Gly Lys Pro Tyr 
 225                230                235                240
Leu Thr Leu Glu Gln Leu Met Asp Phe Ile Asn Gln Lys Gln Arg Asp 
                 245                250                255
Pro Arg Leu Asn Glu Val Leu Tyr Pro Pro Leu Arg Pro Ser Gln Ala 
             260                265                270
Arg Leu Leu Ile Glu Lys Tyr Glu Pro Asn Gln Gln Phe Leu Glu Arg 
         275                280                285
Asp Gln Met Ser Met Glu Gly Phe Ser Arg Tyr Leu Gly Gly Glu Glu 
     290                295                300
Asn Gly Ile Leu Pro Leu Glu Ala Leu Asp Leu Ser Thr Asp Met Thr 
 305                310                315                320
Gln Pro Leu Ser Ala Tyr Phe Ile Asn Ser Ser His Asn Thr Tyr Leu 
                 325                330                335
Thr Ala Gly Gln Leu Ala Gly Thr Ser Ser Val Glu Met Tyr Arg Gln 
             340                345                350
Ala Leu Leu Trp Gly Cys Arg Cys Val Glu Leu Asp Val Trp Lys Gly 
         355                360                365
Arg Pro Pro Glu Glu Glu Pro Phe Ile Thr His Gly Phe Thr Met Thr 
     370                375                380
Thr Glu Val Pro Leu Arg Asp Val Leu Glu Ala Ile Ala Glu Thr Ala 
 385                390                395                400
Phe Lys Thr Ser Pro Tyr Pro Val Ile Leu Ser Phe Glu Asn His Val 
                 405                410                415
Asp Ser Ala Lys Gln Gln Ala Lys Met Ala Glu Tyr Cys Arg Ser Ile 
             420                425                430
Phe Gly Asp Ala Leu Leu Ile Glu Pro Leu Asp Lys Tyr Pro Leu Ala 
         435                440                445
Pro Gly Val Pro Leu Pro Ser Pro Gln Asp Leu Met Gly Arg Ile Leu 
     450                455                460
Val Lys Asn Lys Lys Arg His Arg Pro Ser Ala Gly Gly Pro Asp Ser 
 465                470                475                480
Ala Gly Arg Lys Arg Pro Leu Glu Gln Ser Asn Ser Ala Leu Ser Glu 
                 485                490                495
Ser Ser Ala Ala Thr Glu Pro Ser Ser Pro Gln Leu Gly Ser Pro Ser 
             500                505                510
Ser Asp Ser Cys Pro Gly Leu Ser Asn Gly Glu Glu Val Gly Leu Glu 
         515                520                525
Lys Pro Ser Leu Glu Pro Gln Lys Ser Leu Gly Asp Glu Gly Leu Asn 
     530                535                540
Arg Gly Pro Tyr Val Leu Gly Pro Ala Asp Arg Glu Asp Glu Glu Glu 
 545                550                555                560
Asp Glu Glu Glu Glu Glu Gln Thr Asp Pro Lys Lys Pro Thr Thr Asp 
                 565                570                575
Glu Gly Thr Ala Ser Ser Glu Val Asn Ala Thr Glu Glu Met Ser Thr 
             580                585                590
Leu Val Asn Tyr Ile Glu Pro Val Lys Phe Lys Ser Phe Glu Ala Ala 
         595                600                605
Arg Lys Arg Asn Lys Cys Phe Glu Met Ser Ser Phe Val Glu Thr Lys 
     610                615                620
Ala Met Glu Gln Leu Thr Lys Ser Pro Met Glu Phe Val Glu Tyr Asn 
 625                630                635                640
Lys Gln Gln Leu Ser Arg Ile Tyr Pro Lys Gly Thr Arg Val Asp Ser 
                 645                650                655
Ser Asn Tyr Met Pro Gln Leu Phe Trp Asn Val Gly Cys Gln Leu Val 
             660                665                670
Ala Leu Asn Phe Gln Thr Leu Asp Val Ala Met Gln Leu Asn Ala Gly 
         675                680                685
Val Phe Glu Tyr Asn Gly Arg Ser Gly Tyr Leu Leu Lys Pro Glu Phe 
     690                695                700
Met Arg Arg Pro Asp Lys Ser Phe Asp Pro Phe Thr Glu Val Ile Val 
 705                710                715                720
Asp Gly Ile Val Ala Asn Ala Leu Arg Val Lys Val Ile Ser Gly Gln 
                 725                730                735
Phe Leu Ser Asp Arg Lys Val Gly Ile Tyr Val Glu Val Asp Met Phe 
             740                745                750
Gly Leu Pro Val Asp Thr Arg Arg Lys Tyr Arg Thr Arg Thr Ser Gln 
         755                760                765
Gly Asn Ser Phe Asn Pro Val Trp Asp Glu Glu Pro Phe Asp Phe Pro 
     770                775                780
Lys Val Val Leu Pro Thr Leu Ala Ser Leu Arg Ile Ala Ala Phe Glu 
 785                790                795                800
Glu Gly Gly Lys Phe Val Gly His Arg Ile Leu Pro Val Ser Ala Ile 
                 805                810                815
Arg Ser Gly Tyr His Tyr Val Cys Leu Arg Asn Glu Ala Asn Gln Pro 
             820                825                830
Leu Cys Leu Pro Ala Leu Leu Ile Tyr Thr Glu Ala Ser Asp Tyr Ile 
         835                840                845
Pro Asp Asp His Gln Asp Tyr Ala Glu Ala Leu Ile Asn Pro Ile Lys 
     850                855                860
His Val Ser Leu Met Asp Gln Arg Ala Arg Gln Leu Ala Ala Leu Ile 
 865                870                875                880
Gly Glu Ser Glu Ala Gln Ala Gly Gln Glu Thr Cys Gln Asp Thr Gln 
                 885                890                895
Ser Gln Gln Leu Gly Ser Gln Pro Ser Ser Asn Pro Thr Pro Ser Pro 
             900                905                910
Leu Asp Ala Ser Pro Arg Arg Pro Pro Gly Pro Thr Thr Ser Pro Ala 
         915                920                925
Ser Thr Ser Leu Ser Ser Pro Gly Gln Arg Asp Asp Leu Ile Ala Ser 
     930                935                940
Ile Leu Ser Glu Val Ala Pro Thr Pro Leu Asp Glu Leu Arg Gly His 
 945                950                955                960
Lys Ala Leu Val Lys Leu Arg Ser Arg Gln Glu Arg Asp Leu Arg Glu 
                 965                970                975
Leu Arg Lys Lys His Gln Arg Lys Ala Val Thr Leu Thr Arg Arg Leu 
             980                985                990
Leu Asp Gly Leu Ala Gln Ala Gln Ala Glu Gly Arg Cys Arg Leu Arg 
         995                1000                1005
Pro Gly Ala Leu Gly Gly Ala Ala Asp Val Glu Asp Thr Lys Glu Gly 
     1010                1015                1020
Glu Asp Glu Ala Lys Arg Tyr Gln Glu Phe Gln Asn Arg Gln Val Gln 
 1025                1030                1035                1040
Ser Leu Leu Glu Leu Arg Glu Ala Gln Val Asp Ala Glu Ala Gln Arg 
                 1045                1050                1055
Arg Leu Glu His Leu Arg Gln Ala Leu Gln Arg Leu Arg Glu Val Val 
             1060                1065                1070
Leu Asp Ala Asn Thr Thr Gln Phe Lys Arg Leu Lys Glu Met Asn Glu 
         1075                1080                1085
Arg Glu Lys Lys Glu Leu Gln Lys Ile Leu Asp Arg Lys Arg His Asn 
     1090                1095                1100
Ser Ile Ser Glu Ala Lys Met Arg Asp Lys His Lys Lys Glu Ala Glu 
 1105                1110                1115                1120
Leu Thr Glu Ile Asn Arg Arg His Ile Thr Glu Ser Val Asn Ser Ile 
                 1125                1130                1135
Arg Arg Leu Glu Glu Ala Gln Lys Gln Arg His Asp Arg Leu Val Ala 
             1140                1145                1150
Gly Gln Gln Gln Val Leu Gln Gln Leu Ala Glu Glu Glu Pro Lys Leu 
         1155                1160                1165
Leu Ala Gln Leu Ala Gln Glu Cys Gln Glu Gln Arg Ala Arg Leu Pro 
     1170                1175                1180
Gln Glu Ile Arg Arg Ser Leu Leu Gly Glu Met Pro Glu Gly Leu Gly 
 1185                1190                1195                1200
Asp Gly Pro Leu Val Ala Cys Ala Ser Asn Gly His Ala Pro Gly Ser 
                 1205                1210                1215
Ser Gly His Leu Ser Gly Ala Asp Ser Glu Ser Gln Glu Glu Asn Thr 
             1220                1225                1230
Gln Leu 
         1235



<210> 4190
<211> 301
<212> DNA
<213> Rattus norvegicus
<308> AA684919
<400> 4190

aaaccccga  tttatttaa  cattttgga  gtttaagag  atggtacca  caattgttt  60
cctccaatc  gcatctcct  gctacatca  agtgtggtg  aatggtggt  aaccctcat  120
gtcatcttg  ctgcatctg  actcacata  gaggcacct  tgggagtat  tgggagggt  180
ctgccagag  ggcttaaca  gatggcaga  atttctgaa  atgggcagc  gcaaaccat  240
agctgtggt  ctgagctgt  ccttgtgct  gagggcagg  ctgtaggta  catgatggt  300
g  301



<210> 4191
<211> 325
<212> DNA
<213> Rattus norvegicus
<308> AA685221
<400> 4191

aaataaatc  tttttttaa  tttggaaaa  aagaatcaa  aggcaggga  aggggggac  60
aggaagagc  gagtaggta  acaccttgc  tctatctca  ggacagact  tggtctcca  120
aaccctggg  tcccttgta  tcctagcac  gggtaggca  agacacttg  gtccctggg  180
ctctctagc  agtctagcc  tatgtatgt  tgtatgtat  tatgtatgt  tgtatgtat  240
tatgtgtgt  tgtggtttc  tagtatagg  tctgtgggg  ttggaggac  aggggccat  300
gaaaatgcc  tatggtgaa  caagg  325



<210> 4192
<211> 371
<212> DNA
<213> Rattus norvegicus
<308> AA685974
<400> 4192

gcctcgcca  agcctttat  gcgcgggca  tccaccggg  tctgcagga  gcacggggg  60
taggatgtc  gagcgggga  cctctggtt  gttgagggt  acctatggc  cantgggag  120
cccccagac  cggaactct  ttaatccct  gtcaggcca  gctgaagag  gatgagctg  180
cttggacaa  ctggattca  cccggttct  tcacttggg  gcattgaag  gcagcgcac  240
ctggtttca  cgggttgtc  ggagagcgc  accactcct  cttcagcag  tgcttcagc  300
gtnagagcc  catgttggg  ttttcctgc  tcaaccgtg  cagcttcan  tcctcaaat  360
cggtgaagg  c  371



<210> 4193
<211> 217
<212> PRT
<213> Rattus norvegicus
<308> BAB25123
<400> 4193

Met Pro Lys Lys Phe Gln Gly Glu Asn Ser Lys Ser Ala Ala Ala Arg 
  1               5                  10                  15
Ala Arg Arg Ala Glu Ala Lys Ala Ala Ala Asp Ala Lys Lys Gln Lys 
             20                  25                  30
Glu Leu Glu Asp Ala Tyr Trp Lys Asp Glu Asp Lys His Val Met Arg 
         35                  40                  45
Lys Glu Gln Arg Lys Glu Glu Lys Glu Lys Arg Arg Leu Glu Gln Leu 
     50                  55                  60
Glu Arg Lys Lys Glu Thr Gln Arg Leu Leu Glu Glu Glu Asp Ser Arg 
 65                  70                  75                  80
Leu Lys Gly Gly Lys Ala Pro Arg Val Ala Pro Ala Lys Val Thr Arg 
                 85                  90                  95
Ala Gln Ile Glu Asp Ser Leu Arg Arg Glu Gln Arg Ala Glu Pro Val 
             100                105                110
Glu Lys Ala Lys Ser His Leu Glu Leu Pro Leu Glu Glu Asn Leu Asn 
         115                120                125
Arg Arg Leu Gln Glu Glu Gly Ser Val Glu Ala Arg Thr Val Glu Asp 
     130                135                140
Ala Ile Ala Val Leu Ser Val Ala Glu Glu Ala Asp Arg His Pro Glu 
 145                150                155                160
Arg Arg Met Arg Ala Ala Phe Thr Ala Phe Glu Glu Val Gln Leu Pro 
                 165                170                175
Arg Leu Lys Gln Glu Asn Pro Asn Met Arg Leu Ser Gln Leu Lys Gln 
             180                185                190
Leu Leu Lys Lys Glu Trp Leu Arg Ser Pro Asp Asn Pro Met Asn Gln 
         195                200                205
Arg Ala Leu Pro Phe Asn Ala Pro Lys 
     210                215



<210> 4194
<211> 1070
<212> DNA
<213> Homo sapiens
<308> BC013949
<400> 4194

ggcacgagg  agacggact  ttgctatgt  gcccaggct  gtcttgaac  cctggcctc  60
agcaatcct  ctgcctcag  ctcccaaag  acggggatt  caaaccctg  tgagggatg  120
ccaagaagt  ccagggtga  aacaccaag  cggcagcgg  ccgggcacg  agggcagag  180
ccaaggcgg  cgctgatgc  aagaagcag  aggagctgg  ggatgccta  tggaaggac  240
acgacaaac  cgtcatgag  aaggagcag  gcaaggagg  gaaggagaa  cggcgcctc  300
accagctgg  acgtaagaa  gagacgcag  gcctactgg  ggaggagga  tccaagctc  360
agggcggca  ggcgccgcg  gtggccacg  ccagcaagg  cacccgggc  cagatcgag  420
acacgctgc  ccgagacca  cagctcagg  aggccccgg  cacagccga  aaagccaag  480
gccatctgg  ggtgccgct  gaggagaac  tgaaccgcc  cgtgctgga  gagggcagc  540
tggaggcgc  caccatcga  gacgccatt  cagtgctca  cgtggcgga  gaggcggcc  600
accggcacc  agaaagacg  atgcgggca  ccttcacag  ctttgagga  gcccagctg  660
cgcggctca  acaagagaa  cccaacatg  ggctgtcgc  gctgaaaca  ctgctcaag  720
aggagtggc  ccgctctcc  gacaacccc  tgaaccagc  ggccgtgcc  ttcaatgcc  780
ccaagtgag  ccagaactt  gggagccag  tcacccacg  ggtggtcca  gtcacgact  840
tgcacgccc  taggccagg  cagctgcga  ggtcacaga  cgttccggg  gccaaggcg  900
cgggccccg  ggccatgct  ttatcacca  ccacccgtc  tcccgccag  gggtccctg  960
cccgagtga  accccatcc  ctcccatcc  ccggcgcgt  tgtgtagag  ctcagggct  1020
agtgcccaa  aaaggtggc  gcaaggcta  aaaaaaaaa  aaaaaaaaaa  1070



<210> 4195
<211> 223
<212> PRT
<213> Homo sapiens
<308> AAH13949
<400> 4195

Met Pro Lys Lys Phe Gln Gly Glu Asn Thr Lys Ser Ala Ala Ala Arg 
  1               5                  10                  15
Ala Arg Arg Ala Glu Ala Lys Ala Ala Ala Asp Ala Lys Lys Gln Lys 
             20                  25                  30
Glu Leu Glu Asp Ala Tyr Trp Lys Asp Asp Asp Lys His Val Met Arg 
         35                  40                  45
Lys Glu Gln Arg Lys Glu Glu Lys Glu Lys Arg Arg Leu Asp Gln Leu 
     50                  55                  60
Glu Arg Lys Lys Glu Thr Gln Arg Leu Leu Glu Glu Glu Asp Ser Lys 
 65                  70                  75                  80
Leu Lys Gly Gly Lys Ala Pro Arg Val Ala Thr Ser Ser Lys Val Thr 
                 85                  90                  95
Arg Ala Gln Ile Glu Asp Thr Leu Arg Arg Asp His Gln Leu Arg Glu 
             100                105                110
Ala Pro Asp Thr Ala Glu Lys Ala Lys Ser His Leu Glu Val Pro Leu 
         115                120                125
Glu Glu Asn Val Asn Arg Arg Val Leu Glu Glu Gly Ser Val Glu Ala 
     130                135                140
Arg Thr Ile Glu Asp Ala Ile Ala Val Leu Ser Val Ala Glu Glu Ala 
 145                150                155                160
Ala Asp Arg His Pro Glu Arg Arg Met Arg Ala Ala Phe Thr Ala Phe 
                 165                170                175
Glu Glu Ala Gln Leu Pro Arg Leu Lys Gln Glu Asn Pro Asn Met Arg 
             180                185                190
Leu Ser Gln Leu Lys Gln Leu Leu Lys Lys Glu Trp Leu Arg Ser Pro 
         195                200                205
Asp Asn Pro Met Asn Gln Arg Ala Val Pro Phe Asn Ala Pro Lys 
     210                215                220



<210> 4196
<211> 373
<212> DNA
<213> Rattus norvegicus
<308> AA686164
<400> 4196

cagttgata  tgttttact  tgacttaga  ctttttccc  caagaacaa  attatttgc  60
taaaaattc  ggtatctga  agactcaaa  ggctatttt  cactttgtt  aagtnctgc  120
tccaggcat  aagagtgtc  tacagttgt  gccactgct  ttttccaaa  gtccgatgt  180
tgctgtgac  gacaactac  tttctttgt  tctgatcga  tttgcagta  accatttta  240
ttcttacag  atcaataac  aatgcttca  catcatcag  tccaatctg  agctcttgc  300
gcattgtat  aaaagaaat  tctttgttt  ccactgcca  tcccataaa  gtgaggngt  360
tcattttcg  cat  373



<210> 4197
<211> 374
<212> PRT
<213> Rattus norvegicus
<308> AAH05598
<400> 4197

Met Ser Val Pro Ala Phe Ile Asp Ile Ser Glu Glu Asp Gln Ala Ala 
  1               5                  10                  15
Glu Leu Arg Ala Tyr Leu Lys Ser Lys Gly Ala Glu Leu Ser Glu Glu 
             20                  25                  30
Asn Ser Glu Gly Gly Leu His Val Asp Leu Ala Gln Ile Ile Glu Ala 
         35                  40                  45
Cys Asp Val Cys Leu Lys Glu Asp Asp Lys Asp Val Glu Ser Val Met 
     50                  55                  60
Asn Ser Val Val Ser Leu Leu Leu Ile Leu Glu Pro Asp Lys Gln Glu 
 65                  70                  75                  80
Ala Leu Ile Glu Ser Leu Cys Glu Lys Leu Val Lys Phe Arg Glu Gly 
                 85                  90                  95
Glu Arg Pro Ser Leu Arg Leu Gln Leu Leu Ser Asn Leu Phe His Gly 
             100                105                110
Met Asp Lys Asn Thr Pro Val Arg Tyr Thr Val Tyr Cys Ser Leu Ile 
         115                120                125
Lys Val Ala Ala Ser Cys Gly Ala Ile Gln Tyr Ile Pro Thr Glu Leu 
     130                135                140
Asp Gln Val Arg Lys Trp Ile Ser Asp Trp Lys Leu Thr Thr Glu Lys 
 145                150                155                160
Lys His Thr Leu Leu Arg Leu Leu Tyr Glu Ala Leu Val Asp Cys Lys 
                 165                170                175
Lys Ser Asp Ala Ala Ser Lys Val Met Val Glu Leu Leu Gly Ser Tyr 
             180                185                190
Thr Glu Asp Asn Ala Ser Gln Ala Arg Val Asp Ala His Arg Cys Ile 
         195                200                205
Val Arg Ala Leu Lys Asp Pro Asn Ala Phe Leu Phe Asp His Leu Leu 
     210                215                220
Thr Leu Lys Pro Val Lys Phe Leu Glu Gly Glu Leu Ile His Asp Leu 
 225                230                235                240
Leu Thr Ile Phe Val Ser Ala Lys Leu Ala Ser Tyr Val Lys Phe Tyr 
                 245                250                255
Gln Asn Asn Lys Asp Phe Ile Asp Ser Leu Gly Leu Leu His Glu Gln 
             260                265                270
Asn Met Ala Lys Met Arg Leu Leu Thr Phe Met Gly Met Ala Val Glu 
         275                280                285
Asn Lys Glu Ile Ser Phe Asp Thr Met Gln Gln Glu Leu Gln Ile Gly 
     290                295                300
Ala Asp Asp Val Glu Ala Phe Val Ile Asp Ala Val Arg Thr Lys Met 
 305                310                315                320
Val Tyr Cys Lys Ile Asp Gln Thr Gln Arg Lys Val Val Val Ser His 
                 325                330                335
Ser Thr His Arg Thr Phe Gly Lys Gln Gln Trp Gln Gln Leu Tyr Asp 
             340                345                350
Thr Leu Asn Ala Trp Lys Gln Asn Leu Asn Lys Val Lys Asn Ser Leu 
         355                360                365
Leu Ser Leu Ser Asp Thr 
     370



<210> 4198
<211> 1249
<212> DNA
<213> Homo sapiens
<308> AF064603
<400> 4198

gggtcggcg  ggtcttgcg  gtggagtgt  cgctgtgcc  gggcctgca  catgagcgt  60
ccggccttc  tcgacatca  tgaagaaga  caggctgct  agcttcgtg  ttatctgaa  120
tctaaagga  ctgagattt  agaagagaa  tcggaaggt  gacttcatg  tgatttagc  180
caaattatt  aagcctgtg  tgtgtgtct  aaggaggat  ataaagatg  tgaaagtgt  240
gtgaacagt  tggtatccc  actcttgat  ctggaacca  acaagcaag  agctttgat  300
gaaagccta  gtgaaaagc  ggtcaaatt  cgcgaaggt  aacgcccgt  tctgagact  360
cagttgtta  gcaaccttt  ccacgggat  gataagaat  ctcctgtaa  atacacagt  420
tattgcagc  ttattgaag  ggtagcatc  tgtggggcc  tccagtaca  cccaactga  480
ctggatcaa  ttagaaaat  gatttctga  tggaatctc  ccactgaaa  aaagcacac  540
cttttaaga  tactttatg  ggcacttgc  gattgtaag  agagtgatg  tgcttcaaa  600
gtcatggtg  aattgctcg  aagttacac  gaggacaat  cttcccagg  tcgagttga  660
gcccacagg  gtattgtcg  accattgaa  gatccaaat  catttcttt  tgaccacct  720
cttacttta  aaccagtca  gtttttgga  ggcgagctt  ttcatgatc  tttaaccat  780
tttgtgagt  ctaaattgg  atcatatgt  aagttttat  agaataata  agacttcat  840
gattcactt  gcctgttac  tgaacagaa  atggcaaaa  tgagactac  tacttttat  900
ggaatggca  tagaaaata  ggaaatttc  tttgacaca  tgcagcaag  acttcagat  960
ggagctgat  atgttgaag  atttgttat  gacgccgta  gaactaaaa  ggtctactg  1020
aaaattgat  agacccaga  aaaagtagt  gtcagtcat  gcacacatc  gacatttgg  1080
aaacagcgg  ggcaacaac  gtatgacac  cttaatgcc  ggaaacaaa  tctgaacaa  1140
gtgaaaaac  gccttttga  tctttccga  acctgagtt  ttatgctta  aatttttgt  1200
ctttgaaaa  aaagcccta  atcatagta  gacattata  accaaaaaa  1249



<210> 4199
<211> 375
<212> PRT
<213> Homo sapiens
<308> AF064603
<400> 4199

Met Ser Val Pro Ala Phe Ile Asp Ile Ser Glu Glu Asp Gln Ala Ala 
  1               5                  10                  15
Glu Leu Arg Ala Tyr Leu Lys Ser Lys Gly Ala Glu Ile Ser Glu Glu 
             20                  25                  30
Asn Ser Glu Gly Gly Leu His Val Asp Leu Ala Gln Ile Ile Glu Ala 
         35                  40                  45
Cys Asp Val Cys Leu Lys Glu Asp Asp Lys Asp Val Glu Ser Val Val 
     50                  55                  60
Asn Ser Val Val Ser Leu Leu Leu Ile Leu Glu Pro Asp Lys Gln Glu 
 65                  70                  75                  80
Ala Leu Ile Glu Ser Leu Cys Glu Lys Leu Val Lys Phe Arg Glu Gly 
                 85                  90                  95
Glu Arg Pro Ser Leu Arg Leu Gln Leu Leu Ser Asn Leu Phe His Gly 
             100                105                110
Met Asp Lys Asn Thr Pro Val Arg Tyr Thr Val Tyr Cys Ser Leu Ile 
         115                120                125
Glu Val Val Ala Ser Cys Gly Ala Ile Gln Tyr Ile Pro Thr Glu Leu 
     130                135                140
Asp Gln Val Arg Lys Trp Ile Ser Asp Trp Asn Leu Thr Thr Glu Lys 
 145                150                155                160
Lys His Thr Leu Leu Arg Leu Leu Tyr Glu Ala Leu Ala Asp Cys Lys 
                 165                170                175
Lys Ser Asp Ala Ala Ser Lys Val Met Val Glu Leu Leu Gly Ser Tyr 
             180                185                190
Thr Glu Asp Asn Ala Ser Gln Ala Arg Val Asp Ala His Arg Cys Ile 
         195                200                205
Val Glu Pro Leu Lys Asp Pro Asn Ala Phe Leu Phe Asp His Leu Leu 
     210                215                220
Thr Leu Lys Pro Val Lys Phe Leu Glu Gly Glu Leu Ile His Asp Leu 
 225                230                235                240
Leu Thr Ile Phe Val Ser Ala Lys Leu Ala Ser Tyr Val Lys Phe Tyr 
                 245                250                255
Gln Asn Asn Lys Asp Phe Ile Asp Ser Leu Gly Leu Leu His Glu Gln 
             260                265                270
Asn Met Ala Lys Met Arg Leu Leu Thr Phe Met Gly Met Ala Ile Glu 
         275                280                285
Asn Lys Glu Ile Ser Phe Asp Thr Met Gln Gln Glu Leu Gln Ile Gly 
     290                295                300
Ala Asp Asp Val Glu Ala Phe Val Ile Asp Ala Val Arg Thr Lys Met 
 305                310                315                320
Val Tyr Cys Lys Ile Asp Gln Thr Gln Arg Lys Val Val Val Ser His 
                 325                330                335
Ser Thr His Arg Thr Phe Gly Lys Gln Arg Trp Gln Gln Leu Tyr Asp 
             340                345                350
Thr Leu Asn Ala Trp Lys Gln Asn Leu Asn Lys Val Lys Asn Ser Leu 
         355                360                365
Leu Ser Leu Ser Asp Thr Ter 
     370                375



<210> 4200
<211> 619
<212> DNA
<213> Rattus norvegicus
<308> AA799279
<400> 4200

cccaagatt  aatgattat  aaaaaagcg  gccactgta  agaaatcaa  attctctcc  60
ataattctg  gcattggga  tatagaaat  tcactgtcc  tgctccaca  cttcaaatt  120
acattctca  gtcacaata  taagtcttc  cacaaggaa  cttccggaa  aacaagctg  180
ttcctcggc  catatttcc  gctttttgt  gcatgcacc  gcaatctat  caagaagta  240
atattgggg  gtaaggagg  gatccacca  caagcccac  gttgttaac  gccataaga  300
tagatacaa  cacaaaggg  tatgtcaac  tactggcaa  gaatcctgt  acagcttgg  360
aataacttt  catttcatt  atggtagag  ccccactgt  cagtgcata  gtattgatg  420
gataagcca  tgagttaca  agccacaaa  aaatgatgt  acctaggag  cgaggaatg  480
ggcccgcaa  aaatcctac  atgccttct  cccggtaga  ggttactat  gagtcacac  540
gtccgcagt  cttagactc  ctgccgata  actgtacca  ggacctcag  gtaatcacc  600
tgaagggat  tgtaatgag  619



<210> 4201
<211> 619
<212> DNA
<213> Rattus norvegicus
<308> AA799279
<400> 4201

cccaagatt  aatgattat  aaaaaagcg  gccactgta  agaaatcaa  attctctcc  60
ataattctg  gcattggga  tatagaaat  tcactgtcc  tgctccaca  cttcaaatt  120
acattctca  gtcacaata  taagtcttc  cacaaggaa  cttccggaa  aacaagctg  180
ttcctcggc  catatttcc  gctttttgt  gcatgcacc  gcaatctat  caagaagta  240
atattgggg  gtaaggagg  gatccacca  caagcccac  gttgttaac  gccataaga  300
tagatacaa  cacaaaggg  tatgtcaac  tactggcaa  gaatcctgt  acagcttgg  360
aataacttt  catttcatt  atggtagag  ccccactgt  cagtgcata  gtattgatg  420
gataagcca  tgagttaca  agccacaaa  aaatgatgt  acctaggag  cgaggaatg  480
ggcccgcaa  aaatcctac  atgccttct  cccggtaga  ggttactat  gagtcacac  540
gtccgcagt  cttagactc  ctgccgata  actgtacca  ggacctcag  gtaatcacc  600
tgaagggat  tgtaatgag  619



<210> 4202
<211> 506
<212> DNA
<213> Rattus norvegicus
<308> AA799299
<400> 4202

aaaggacag  ttaaatagg  aatgcagaa  gaaaggtgg  cccagtggc  gtaaacaga  60
aggagtgag  accatcacc  ccaggggca  gtgtccccc  gacagccat  gctgctggc  120
tacaggctc  ctgggctca  aggggaagt  actagggat  gggacaggg  ccaaggaca  180
gtgagtatc  acagagcct  cctgtgtaa  gagatcaaa  agtaaagaa  tggagagag  240
tgccagctc  tccttctcc  tgatagatg  cagcatctt  cccctcgac  atccagagc  300
gacttctgc  cgaagcagg  ccccagtag  gaggtgggt  tagccatat  tctgcacaa  360
cttctcaca  tgggtacct  ttcctgagc  aggcccgcc  accacgaag  tgatcttgg  420
cttcttcag  ttgtcttcc  tcctgctga  gtctgggag  taggtcagc  ctctggggg  480
gggtgtggt  ggcgctggg  ccagtc  506



<210> 4203
<211> 123
<212> PRT
<213> Rattus norvegicus
<308> P39069
<400> 4203

Val Leu Asp Met Leu Arg Asp Ala Met Leu Ala Lys Val Asp Ser Ser 
  1               5                  10                  15
Asn Gly Phe Leu Ile Asp Gly Tyr Pro Arg Glu Val Lys Gln Gly Glu 
             20                  25                  30
Ser Phe Glu Arg Lys Ile Ala Gln Pro Thr Leu Leu Leu Tyr Val Asp 
         35                  40                  45
Ala Gly Pro Glu Thr Met Thr Gln Arg Leu Leu Lys Arg Gly Glu Thr 
     50                  55                  60
Ser Gly Arg Val Asp Asp Asn Glu Glu Thr Ile Lys Lys Arg Leu Glu 
 65                  70                  75                  80
Thr Tyr Tyr Lys Ala Thr Glu Pro Val Ile Ser Phe Tyr Asp Lys Arg 
                 85                  90                  95
Gly Ile Val Arg Lys Val Asn Leu Glu Gly Ser Trp Asp Thr Val Phe 
             100                105                110
Ser Gln Val Ser Thr Tyr Leu Asp Ser Leu Lys 
         115                120



<210> 4204
<211> 585
<212> DNA
<213> Homo sapiens
<308> AB021871
<400> 4204

atggaagag  agctgaaga  aaccaagat  atctttgtg  tgggtgggc  tggctcagg  60
aagggcacc  agtgtgaga  gatcgtgca  aagtatggc  acacccacc  ctccaccgg  120
gacctcctg  ggtccgagg  cagctcagg  tcggccagg  gcaagaagc  gtcggaaat  180
atggagaag  ggcagctgg  tccactgga  acagtgttg  acatgctcc  ggatgccat  240
gtggccaaa  tcaatactt  caaaggctt  ctgattgat  gctacccgc  ggaggtgca  300
caaggagaa  agtttgagc  acggattgg  cagcccaca  tgctgctgt  tgtggacgc  360
ggccctgag  ccatgaccc  gcggctctt  aaacgtgga  agaccagcg  gcgtgtgga  420
gacaatgag  agaccatca  aaagcggct  gagacctat  acaaggcca  agaacccgt  480
atcgccttc  atgagaaac  tggcattgt  cgcaaggtc  acgctgagg  ctccgtgga  540
agtgtcttc  cccaggtct  cacccacct  gacgcccta  agtag  585



<210> 4205
<211> 194
<212> PRT
<213> Homo sapiens
<308> P00568
<400> 4205

Met Glu Glu Lys Leu Lys Lys Thr Lys Ile Ile Phe Val Val Gly Gly 
  1               5                  10                  15
Pro Gly Ser Gly Lys Gly Thr Gln Cys Glu Lys Ile Val Gln Lys Tyr 
             20                  25                  30
Gly Tyr Thr His Leu Ser Thr Gly Asp Leu Leu Arg Ser Glu Val Ser 
         35                  40                  45
Ser Gly Ser Ala Arg Gly Lys Lys Leu Ser Glu Ile Met Glu Lys Gly 
     50                  55                  60
Gln Leu Val Pro Leu Glu Thr Val Leu Asp Met Leu Arg Asp Ala Met 
 65                  70                  75                  80
Val Ala Lys Val Asn Thr Ser Lys Gly Phe Leu Ile Asp Gly Tyr Pro 
                 85                  90                  95
Arg Glu Val Gln Gln Gly Glu Glu Phe Glu Arg Arg Ile Gly Gln Pro 
             100                105                110
Thr Leu Leu Leu Tyr Val Asp Ala Gly Pro Glu Thr Met Thr Gln Arg 
         115                120                125
Leu Leu Lys Arg Gly Glu Thr Ser Gly Arg Val Asp Asp Asn Glu Glu 
     130                135                140
Thr Ile Lys Lys Arg Leu Glu Thr Tyr Tyr Lys Ala Thr Glu Pro Val 
 145                150                155                160
Ile Ala Phe Tyr Glu Lys Arg Gly Ile Val Arg Lys Val Asn Ala Glu 
                 165                170                175
Gly Ser Val Asp Ser Val Phe Ser Gln Val Cys Thr His Leu Asp Ala 
             180                185                190
Leu Lys 
         195



<210> 4206
<211> 328
<212> DNA
<213> Rattus norvegicus
<308> AA799323
<400> 4206

atgtgttgt  tacagtcgc  cagaaattg  tttattcag  tgagaagaa  acaggtggg  60
gaactcaga  tacaaaaga  cgaacatct  gtcctcctc  agccttgag  ctttctgga  120
tatccgtga  gtctccaaa  ttcccctgg  aagttacac  ggcacaaga  tgttttctt  180
gagtgccgg  atgcggtga  caaacatac  aagtgagaa  tcttgcttc  gtgaatatt  240
aataaacaa  aatgctaca  ctgggaccc  tctgagtga  ggcgtacga  agaacgcca  300
ctgaaagtt  aaagtctgg  catgaatt  328



<210> 4207
<211> 350
<212> PRT
<213> Rattus norvegicus
<308> NP_062422
<400> 4207

Met Glu Pro Lys Arg Ile Arg Glu Gly Tyr Leu Val Lys Lys Gly Ser 
  1               5                  10                  15
Val Phe Asn Thr Trp Lys Pro Met Trp Val Val Leu Leu Glu Asp Gly 
             20                  25                  30
Ile Glu Phe Tyr Lys Lys Lys Ser Asp Asn Ser Pro Lys Gly Met Ile 
         35                  40                  45
Pro Leu Lys Gly Ser Thr Leu Thr Ser Pro Cys Gln Asp Phe Gly Lys 
     50                  55                  60
Arg Met Phe Val Leu Lys Ile Thr Thr Thr Lys Gln Gln Asp His Phe 
 65                  70                  75                  80
Phe Gln Ala Ala Phe Leu Glu Glu Arg Asp Ala Trp Val Arg Asp Ile 
                 85                  90                  95
Lys Lys Ala Ile Lys Cys Ile Glu Gly Gly Gln Lys Phe Ala Arg Lys 
             100                105                110
Ser Thr Arg Arg Ser Ile Arg Leu Pro Glu Thr Ile Asp Leu Gly Ala 
         115                120                125
Leu Tyr Leu Ser Met Lys Asp Pro Glu Lys Gly Ile Lys Glu Leu Asn 
     130                135                140
Leu Glu Lys Asp Lys Lys Val Phe Asn His Cys Leu Thr Gly Ser Gly 
 145                150                155                160
Val Ile Asp Trp Leu Val Ser Asn Lys Leu Val Arg Asn Arg Gln Glu 
                 165                170                175
Gly Leu Met Ile Ser Ala Ser Leu Leu Ser Glu Gly Tyr Leu Gln Pro 
             180                185                190
Ala Gly Asp Leu Ser Lys Asn Ala Ala Asp Gly Ile Ala Glu Asn Pro 
         195                200                205
Phe Leu Asp Ser Pro Asp Ala Phe Tyr Tyr Phe Pro Asp Ser Gly Phe 
     210                215                220
Phe Cys Glu Glu Asn Ser Ser Asp Asp Asp Val Ile Leu Arg Glu Glu 
 225                230                235                240
Phe Arg Gly Val Ile Ile Lys Gln Gly Cys Leu Leu Lys Gln Gly His 
                 245                250                255
Arg Arg Lys Asn Trp Lys Val Arg Lys Phe Ile Leu Arg Glu Asp Pro 
             260                265                270
Ala Tyr Leu His Tyr Tyr Asp Pro Ala Gly Gly Glu Asp Pro Leu Gly 
         275                280                285
Ala Val His Leu Arg Gly Cys Val Val Thr Ser Val Glu Ser Ser His 
     290                295                300
Asp Val Lys Lys Ser Asp Glu Glu Asn Leu Phe Glu Ile Ile Thr Ala 
 305                310                315                320
Asp Glu Val His Tyr Tyr Leu Gln Ala Ala Thr Ser Lys Glu Arg Thr 
                 325                330                335
Glu Trp Ile Lys Ala Ile Gln Val Ala Ser Arg Thr Gly Lys 
             340                345                350



<210> 4208
<211> 2745
<212> DNA
<213> Homo sapiens
<308> X07743
<400> 4208

ggcccagct  ctgagagga  ttgcctgag  gtgaccttt  catctgcct  tccagccag  60
atggaacca  agcggatca  agagggcta  cttgtgaag  aggggagcg  gttcaatac  120
tggaaaccc  tgtgggttg  attgttaga  gatggaatt  aattctata  gaagaaaag  180
gacaacagc  ccaaaggaa  gatcccgct  aaagggagc  ctctgacta  cccttgtca  240
gactttggc  aaaggatgt  tgtgtttaa  atcactacg  ccaaacagc  ggaccactt  300
ttccaggca  ccttcctgg  ggagagaga  gcctgggtt  gggatatca  taaggccat  360
aaatgcatt  aaggaggcc  gaaatttgc  aggaaatct  ccaggaggt  cattcgact  420
ccagaaacc  ttgacttag  tgccttata  ttgtccatg  aagacactg  aaaaggaat  480
aaagaactg  atctagaga  ggacaagaa  atttttaat  actgcttca  aggtaactg  540
gtcattgat  ggctggtat  caaccagtc  gttaggaat  gccaggaag  cctcatgat  600
gcttcatcg  tgctcaatg  ggggtatct  cagcctgct  gagacatgt  caagagtgc  660
gtggatgga  ctgctgaaa  ccctttcct  gacaaccct  atgccttct  ctactttcc  720
gacagtggg  tcttctgtg  agagaattc  agtgatgat  atgtgattc  gaaagaaga  780
ttcagaggg  tcattatca  gcagggatg  ttactgaag  aggggcata  aaggaaaaa  840
tggaaagtg  ggaagttca  cttgagaga  gaccctgcc  acctgcact  ctatgaccc  900
gctggggca  aagatcccc  gggagcaat  cacttgaga  gctgtgtgg  gacttcagt  960
gagagcaac  caaatggca  gaagagtga  gaagagaac  tttttgaga  catcacagc  1020
gatgaagtg  actatttct  gcaagcagc  acccccaag  agcgcacag  gtggatcaa  1080
gccatccag  tggcctccc  aactgggaa  taaagagac  cctgcattc  tcctcccct  1140
ctgagggaa  cccatggac  agctcagtc  aggacctgt  cacttctgt  acaaatcaa  1200
gggaaacag  ccaggggtg  gaagttttc  tttgcaggg  ggtctgaat  taactcacc  1260
tgtggtgtg  aaggttccc  tgcattgta  tgctcactg  agcccctct  cccctatcc  1320
tgaccccca  gcagatata  caagctgtg  agcctcagt  ggctgcttg  cctctccag  1380
ctcagggcc  cttctggaa  atgaagaaa  tcaactagt  gattcctga  gtcccccta  1440
cttaaaaaa  aaaaaatct  ccccatgat  ctaacactc  cagtagtga  agtgtatct  1500
gttgttctg  tggtgtcct  ccttggcta  gtcttggcc  tcagttatc  tcaaatgta  1560
cagaacctg  gccaacgcc  ccctgtgaa  ctgttgctg  tctgtagta  agtaccagg  1620
agaaacctc  tttgttctc  ttagacatc  tctacttgc  cttggcctt  agatcgtgt  1680
acaaaatga  ggagggctc  cttctttct  cctcatcct  ctcaaaaac  tcccgagag  1740
agtggtggt  ttgagggtt  tgacttcta  tacttttgg  agcctggaa  gttgtgtct  1800
ctgggaaag  gacccgggg  ggccaggag  agctgaggg  cctttctgt  cccttaaac  1860
gcccagagg  gccctattc  actctggtt  taggctgat  tgagagggt  tccctttgt  1920
cctttctgg  gcatttctc  aacgtttat  acaattagg  gggggaccc  acatctgtg  1980
gattctgtt  catttgagg  ttacagaaa  aaaaaagtg  ccagatgtg  tccccccat  2040
ggtgagagg  ctgggcaac  gcctggtga  tgtgtcttg  ggcagctgc  gcaagtgga  2100
gggctgaac  actggccag  tcactggat  atgggttaa  acaacaact  cactgtaag  2160
actcagagc  acacagaac  tctgagagg  gctgttagc  ttgcgcagc  tcttcagtt  2220
tccagtaaa  gatattgcg  tcgtgcctc  gctttaagc  caagtagca  cagctcctg  2280
ttgagttct  agggcatca  ggccctatg  ttaaccaga  tgatctaac  tagactaaa  2340
ttgggaact  atttgcaat  tttgaccct  accactaac  agtgattct  ctccaaaat  2400
gagaaagac  gcacccatt  aaacagata  gtgtgtgaa  gtatatttt  caattccag  2460
tttttaatt  taaggctcc  ggaaagaaa  gagagtaga  catttttcc  cattttatc  2520
aatcctctc  tgccctccc  caattcccc  gtaacattc  tgaagctgt  cccactccc  2580
gatggtttt  tcaatagcc  agaggtaaa  aactgtctt  ttctctgat  ctttaataa  2640
ttatcttta  agaatatgc  caagttttt  tacactcag  gttaaagta  ttattaatg  2700
gaagtcaac  taatgtttt  aaataaata  atgactctg  ttaat  2745



<210> 4209
<211> 350
<212> PRT
<213> Homo sapiens
<308> P08567
<400> 4209

Met Glu Pro Lys Arg Ile Arg Glu Gly Tyr Leu Val Lys Lys Gly Ser 
  1               5                  10                  15
Val Phe Asn Thr Trp Lys Pro Met Trp Val Val Leu Leu Glu Asp Gly 
             20                  25                  30
Ile Glu Phe Tyr Lys Lys Lys Ser Asp Asn Ser Pro Lys Gly Met Ile 
         35                  40                  45
Pro Leu Lys Gly Ser Thr Leu Thr Ser Pro Cys Gln Asp Phe Gly Lys 
     50                  55                  60
Arg Met Phe Val Phe Lys Ile Thr Thr Thr Lys Gln Gln Asp His Phe 
 65                  70                  75                  80
Phe Gln Ala Ala Phe Leu Glu Glu Arg Asp Ala Trp Val Arg Asp Ile 
                 85                  90                  95
Asn Lys Ala Ile Lys Cys Ile Glu Gly Gly Gln Lys Phe Ala Arg Lys 
             100                105                110
Ser Thr Arg Arg Ser Ile Arg Leu Pro Glu Thr Ile Asp Leu Gly Ala 
         115                120                125
Leu Tyr Leu Ser Met Lys Asp Thr Glu Lys Gly Ile Lys Glu Leu Asn 
     130                135                140
Leu Glu Lys Asp Lys Lys Ile Phe Asn His Cys Phe Thr Gly Asn Cys 
 145                150                155                160
Val Ile Asp Trp Leu Val Ser Asn Gln Ser Val Arg Asn Arg Gln Glu 
                 165                170                175
Gly Leu Met Ile Ala Ser Ser Leu Leu Asn Glu Gly Tyr Leu Gln Pro 
             180                185                190
Ala Gly Asp Met Ser Lys Ser Ala Val Asp Gly Thr Ala Glu Asn Pro 
         195                200                205
Phe Leu Asp Asn Pro Asp Ala Phe Tyr Tyr Phe Pro Asp Ser Gly Phe 
     210                215                220
Phe Cys Glu Glu Asn Ser Ser Asp Asp Asp Val Ile Leu Lys Glu Glu 
 225                230                235                240
Phe Arg Gly Val Ile Ile Lys Gln Gly Cys Leu Leu Lys Gln Gly His 
                 245                250                255
Arg Arg Lys Asn Trp Lys Val Arg Lys Phe Ile Leu Arg Glu Asp Pro 
             260                265                270
Ala Tyr Leu His Tyr Tyr Asp Pro Ala Gly Ala Glu Asp Pro Leu Gly 
         275                280                285
Ala Ile His Leu Arg Gly Cys Val Val Thr Ser Val Glu Ser Asn Ser 
     290                295                300
Asn Gly Arg Lys Ser Glu Glu Glu Asn Leu Phe Glu Ile Ile Thr Ala 
 305                310                315                320
Asp Glu Val His Tyr Phe Leu Gln Ala Ala Thr Pro Lys Glu Arg Thr 
                 325                330                335
Glu Trp Ile Lys Ala Ile Gln Met Ala Ser Arg Thr Gly Lys 
             340                345                350



<210> 4210
<211> 637
<212> DNA
<213> Rattus norvegicus
<308> AA799328
<400> 4210

agctgtaaa  acaacattt  ttactttat  atattgaga  tgagtattt  ggccaaaac  60
atgggaatg  catacaaat  attttttca  cttatattt  aaaacctac  acagatatt  120
cactgtttt  taattgatt  acctgtatt  gatttggga  aaatacatt  ggcagggga  180
acaaaatat  acacaatag  actaggaaa  gtctggaaa  taaggggag  tgtggatta  240
gatcatgtt  gctctcata  aggacatat  tcagttatg  taaaggaag  attgaagca  300
tcgctggat  ccagcaaca  tccttcagc  tctcatcta  tcctacttt  tctcaaata  360
tctaagatc  ctggccttc  gttcataaa  actccttga  tctgttttt  atgagatta  420
ttctgaacg  agttttctt  ctcttcaaa  gaccaagac  tgagtgtca  actgctgag  480
attgtccca  gttgtgtcc  atatcctcc  agcactctc  attgtgaat  gtatcaagt  540
gaaaccacc  attcccatg  ttgctctcc  caactcaag  ccagaaagt  tcaggtaca  600
gcattctgt  gcagagacc  gctccttgc  tgctcaa  637



<210> 4211
<211> 637
<212> DNA
<213> Rattus norvegicus
<308> AA799328
<400> 4211

agctgtaaa  acaacattt  ttactttat  atattgaga  tgagtattt  ggccaaaac  60
atgggaatg  catacaaat  attttttca  cttatattt  aaaacctac  acagatatt  120
cactgtttt  taattgatt  acctgtatt  gatttggga  aaatacatt  ggcagggga  180
acaaaatat  acacaatag  actaggaaa  gtctggaaa  taaggggag  tgtggatta  240
gatcatgtt  gctctcata  aggacatat  tcagttatg  taaaggaag  attgaagca  300
tcgctggat  ccagcaaca  tccttcagc  tctcatcta  tcctacttt  tctcaaata  360
tctaagatc  ctggccttc  gttcataaa  actccttga  tctgttttt  atgagatta  420
ttctgaacg  agttttctt  ctcttcaaa  gaccaagac  tgagtgtca  actgctgag  480
attgtccca  gttgtgtcc  atatcctcc  agcactctc  attgtgaat  gtatcaagt  540
gaaaccacc  attcccatg  ttgctctcc  caactcaag  ccagaaagt  tcaggtaca  600
gcattctgt  gcagagacc  gctccttgc  tgctcaa  637



<210> 4212
<211> 617
<212> DNA
<213> Rattus norvegicus
<308> AA799330
<400> 4212

tatttaatt  gaatacatg  cctgccaac  aaaccataa  acacttcat  ggaacccat  60
acacatgaa  ccccagcag  accaacaag  gcggccttg  acttgtcaa  gatgctgta  120
aagaagaaa  tattgagtt  ccgtcttaa  cctcttcag  acttgaatc  tcctcttgg  180
cagaaagtt  cggcacagg  aagcggaga  tggcagcta  tccagtcag  tgaccaagc  240
gttccccag  cacgtggag  ctggagaat  tccttacgg  gcccgcatt  tctttcaca  300
tgtccacca  cctgacata  cggctccgg  tggccacat  ctgatgccg  aagagctca  360
cactgatga  caaggtgtc  atcgccaag  cttcattgg  cctctccac  tgcttgagt  420
catagaatg  tcggtcagg  tcgtgctgt  acattttgt  gaagtcatc  aaggctttt  480
cttccccgg  agctttcgt  tctgaaagg  ggctcgcta  agtaggatc  cataggacc  540
ctttcaggg  gtacctgtg  ccagaggag  cgtgtacct  aaggaattt  gagccgttt  600
ccaggagca  cttgttt  617



<210> 4213
<211> 385
<212> PRT
<213> Rattus norvegicus
<308> AAK58116
<400> 4213

Met Lys Leu Val Arg Lys Asp Ile Glu Lys Asp Asn Ala Gly Gln Val 
  1               5                  10                  15
Thr Leu Val Pro Glu Glu Pro Glu Asp Met Trp His Thr Tyr Asn Leu 
             20                  25                  30
Val Gln Val Gly Asp Ser Leu Arg Ala Ser Thr Ile Arg Lys Val Gln 
         35                  40                  45
Thr Glu Ser Ser Thr Gly Ser Val Gly Ser Asn Arg Val Arg Thr Thr 
     50                  55                  60
Leu Thr Leu Cys Val Glu Ala Ile Asp Phe Asp Ser Gln Ala Cys Gln 
 65                  70                  75                  80
Leu Arg Val Lys Gly Thr Asn Ile Gln Glu Asn Glu Tyr Val Lys Met 
                 85                  90                  95
Gly Ala Tyr His Thr Ile Glu Leu Glu Pro Asn Arg Gln Phe Thr Leu 
             100                105                110
Ala Lys Lys Gln Trp Asp Ser Val Val Leu Glu Arg Phe Glu Gln Ala 
         115                120                125
Cys Asp Pro Ala Trp Ser Ala Asp Val Ala Ala Val Val Met Gln Glu 
     130                135                140
Gly Leu Ala His Val Cys Leu Val Thr Pro Ser Met Thr Leu Thr Arg 
 145                150                155                160
Ala Lys Val Glu Val Asn Ile Pro Arg Lys Arg Lys Gly Asn Cys Ser 
                 165                170                175
Gln His Asp Pro Ala Leu Glu Arg Phe Tyr Glu Gln Val Val Gln Ala 
             180                185                190
Ile Gln Arg His Ile Asn Phe Glu Val Val Lys Cys Val Leu Val Ala 
         195                200                205
Ser Pro Gly Phe Val Arg Glu Gln Phe Cys Asp Tyr Met Phe Gln Gln 
     210                215                220
Ala Val Lys Thr Asp Asn Lys Val Leu Leu Glu Asn Arg Ser Lys Phe 
 225                230                235                240
Leu Gln Val His Ala Ser Ser Gly His Lys Tyr Ser Leu Lys Glu Ala 
                 245                250                255
Leu Cys Asp Pro Thr Val Ala Ser Arg Leu Ser His Thr Lys Ala Ala 
             260                265                270
Gly Glu Val Lys Ala Leu Asp Asp Phe Tyr Lys Met Leu Gln His Glu 
         275                280                285
Pro Asp Arg Ala Phe Tyr Gly Leu Lys Gln Val Glu Arg Ala Asn Glu 
     290                295                300
Ala Leu Ala Ile Asp Thr Leu Leu Ile Ser Asp Glu Leu Phe Arg His 
 305                310                315                320
Gln Asp Val Ala Thr Arg Ser Arg Tyr Val Arg Leu Val Asp Ser Val 
                 325                330                335
Lys Glu Asn Ala Gly Thr Val Arg Ile Phe Ser Ser Leu His Val Ser 
             340                345                350
Gly Glu Gln Leu Gly Gln Leu Thr Gly Val Ala Ala Ile Leu Arg Phe 
         355                360                365
Pro Val Pro Glu Leu Ser Asp Gln Glu Asp Asp Ser Ser Ser Glu Glu 
     370                375                380
Asp 
 385



<210> 4215
<211> 385
<212> PRT
<213> Homo sapiens
<308> XP_032895
<400> 4215

Met Lys Leu Val Arg Lys Asn Ile Glu Lys Asp Asn Ala Gly Gln Val 
  1               5                  10                  15
Thr Leu Val Pro Glu Glu Pro Glu Asp Met Trp His Thr Tyr Asn Leu 
             20                  25                  30
Val Gln Val Gly Asp Ser Leu Arg Ala Ser Thr Ile Arg Lys Val Gln 
         35                  40                  45
Thr Glu Ser Ser Thr Gly Ser Val Gly Ser Asn Arg Val Arg Thr Thr 
     50                  55                  60
Leu Thr Leu Cys Val Glu Ala Ile Asp Phe Asp Ser Gln Ala Cys Gln 
 65                  70                  75                  80
Leu Arg Val Lys Gly Thr Asn Ile Gln Glu Asn Glu Tyr Val Lys Met 
                 85                  90                  95
Gly Ala Tyr His Thr Ile Glu Leu Glu Pro Asn Arg Gln Phe Thr Leu 
             100                105                110
Ala Lys Lys Gln Trp Asp Ser Val Val Leu Glu Arg Ile Glu Gln Ala 
         115                120                125
Cys Asp Pro Ala Trp Ser Ala Asp Val Ala Ala Val Val Met Gln Glu 
     130                135                140
Gly Leu Ala His Ile Cys Leu Val Thr Pro Ser Met Thr Leu Thr Arg 
 145                150                155                160
Ala Lys Val Glu Val Asn Ile Pro Arg Lys Arg Lys Gly Asn Cys Ser 
                 165                170                175
Gln His Asp Arg Ala Leu Glu Arg Phe Tyr Glu Gln Val Val Gln Ala 
             180                185                190
Ile Gln Arg His Ile His Phe Asp Val Val Lys Cys Ile Leu Val Ala 
         195                200                205
Ser Pro Gly Phe Val Arg Glu Gln Phe Cys Asp Tyr Leu Phe Gln Gln 
     210                215                220
Ala Val Lys Thr Asp Asn Lys Leu Leu Leu Glu Asn Arg Ser Lys Phe 
 225                230                235                240
Leu Gln Val His Ala Ser Ser Gly His Lys Tyr Ser Leu Lys Glu Ala 
                 245                250                255
Leu Cys Asp Pro Thr Val Ala Ser Arg Leu Ser Asp Thr Lys Ala Ala 
             260                265                270
Gly Glu Val Lys Ala Leu Asp Asp Phe Tyr Lys Met Leu Gln His Glu 
         275                280                285
Pro Asp Arg Ala Phe Tyr Gly Leu Lys Gln Val Glu Lys Ala Asn Glu 
     290                295                300
Ala Met Ala Ile Asp Thr Leu Leu Ile Ser Asp Glu Leu Phe Arg His 
 305                310                315                320
Gln Asp Val Ala Thr Arg Ser Arg Tyr Val Arg Leu Val Asp Ser Val 
                 325                330                335
Lys Glu Asn Ala Gly Thr Val Arg Ile Phe Ser Ser Leu His Val Ser 
             340                345                350
Gly Glu Gln Leu Ser Gln Leu Thr Gly Val Ala Ala Ile Leu Arg Phe 
         355                360                365
Pro Val Pro Glu Leu Ser Asp Gln Glu Gly Asp Ser Ser Ser Glu Glu 
     370                375                380
Asp 
 385



<210> 4216
<211> 637
<212> DNA
<213> Rattus norvegicus
<308> AA799396
<400> 4216

ggaacacca  caaatccgg  actttatta  gacatctta  gcttccctg  attttcaaa  60
acaggaatg  tctattgac  gaacacatc  aagggtctc  gcagagtcc  tgggggcca  120
ccacaggag  tgtcatgtg  ttctgcagt  ccagagcat  gcagctagt  cttgcaatc  180
caggaagca  gcagtcggt  ctccatctg  ctaggggag  gtatccttc  ttcttttga  240
ggactgcct  caagtcaca  ctcaattcc  gtgtgtaga  tcggtctct  ggactgggg  300
caaaggcag  tgccaggtg  aacagttta  gaggctccg  cttttatat  tgccacggg  360
gcccgggct  tgggagcca  aagcccaag  tggaccaac  gctgctgtg  gctgatggc  420
ttagcagcc  cataatctt  cctttgatg  ccagggtca  tgcagtcct  gccccacca  480
ggctaggag  aggtgtatg  aagagaatc  cactgtgat  tgtcctgtg  aggaaacag  540
aataaaatt  attacccag  caccacagt  attctgaca  gagttctcc  agcctctga  600
ctccacttg  gagggaact  tcagggagg  cagggac  637



<210> 4217
<211> 1208
<212> DNA
<213> Homo sapiens
<308> AF043896
<400> 4217

acggagctc  cagctgagg  gctgcttct  cgggctgtc  attggaccc  ccctccggt  60
cctactgag  tgatatcag  tctcatttt  cacactggc  cagttcagc  ggaacagga  120
tcgagccct  gagcaaaaa  ccttcgtgt  tgtaagtgc  cgagctcag  agagctggg  180
ctcccactc  cggcagaca  gcccgcgtc  accctgcgt  caccccggc  cggcggcag  240
acggtgcca  tcatctgca  gtgctcctg  ggcgtgggg  tttgtagac  tggaaaacc  300
tgttggcag  aagttaaga  ctcccaggc  tgaaggcag  acacagtgc  agcaggggg  360
cgtttgccc  catgtgtaa  ggaggcagg  cccagctct  ccacggcga  gtgagctga  420
actttctga  aatagttag  gtgggtgcg  gtctgaaat  ggtactcct  ccagctatt  480
tgtacgcaa  gcctgagta  agcctgctg  tgtcatggc  acgtgtgag  aggccagcg  540
cacacggct  gctgtgacc  gtcccggag  ctgaaatgg  cctgggtct  ctccttgtc  600
tgtgattaa  gtcctctct  gaaagtgga  agcaaaggc  cacagaggt  cgcgctcac  660
agaattcct  ccggtgact  ggtaatcaa  gttactgct  tttcctttg  aggaaagac  720
acagcaaga  tctttcatt  gtctcctcc  agcctgggg  accaggctc  aactgaccc  780
ggacatcaa  ggagggatt  tgtggctgc  aaagccatc  gcccacagc  ctgttcacg  840
cttggtgct  ctctttccc  gaggctggt  ccagccagg  acacacaaa  ggcagattc  900
cgtaaacgc  gcctccctc  ctggaggct  cctcctgcc  tggatctgg  gtggagctg  960
tctgagatt  tgagttctt  tgcagagat  attaaatat  tccaagaga  attggaaaa  1020
ctgctgaac  ttttacatt  gtctgctca  cacatggct  gatgcggat  tttctataa  1080
tccagaaag  cacacagct  ctctgtatg  gaccagtgg  cgccattta  aagaacagg  1140
tgagaatct  agatatatt  ttaataaat  taatggatt  tttttttgt  aaaaaaaaa  1200
aaaaaaaa  1208



<210> 4218
<211> 637
<212> DNA
<213> Rattus norvegicus
<308> AA799396
<400> 4218

ggaacacca  caaatccgg  actttatta  gacatctta  gcttccctg  attttcaaa  60
acaggaatg  tctattgac  gaacacatc  aagggtctc  gcagagtcc  tgggggcca  120
ccacaggag  tgtcatgtg  ttctgcagt  ccagagcat  gcagctagt  cttgcaatc  180
caggaagca  gcagtcggt  ctccatctg  ctaggggag  gtatccttc  ttcttttga  240
ggactgcct  caagtcaca  ctcaattcc  gtgtgtaga  tcggtctct  ggactgggg  300
caaaggcag  tgccaggtg  aacagttta  gaggctccg  cttttatat  tgccacggg  360
gcccgggct  tgggagcca  aagcccaag  tggaccaac  gctgctgtg  gctgatggc  420
ttagcagcc  cataatctt  cctttgatg  ccagggtca  tgcagtcct  gccccacca  480
ggctaggag  aggtgtatg  aagagaatc  cactgtgat  tgtcctgtg  aggaaacag  540
aataaaatt  attacccag  caccacagt  attctgaca  gagttctcc  agcctctga  600
ctccacttg  gagggaact  tcagggagg  cagggac  637



<210> 4219
<211> 1208
<212> DNA
<213> Homo sapiens
<308> AF043896
<400> 4219

acggagctc  cagctgagg  gctgcttct  cgggctgtc  attggaccc  ccctccggt  60
cctactgag  tgatatcag  tctcatttt  cacactggc  cagttcagc  ggaacagga  120
tcgagccct  gagcaaaaa  ccttcgtgt  tgtaagtgc  cgagctcag  agagctggg  180
ctcccactc  cggcagaca  gcccgcgtc  accctgcgt  caccccggc  cggcggcag  240
acggtgcca  tcatctgca  gtgctcctg  ggcgtgggg  tttgtagac  tggaaaacc  300
tgttggcag  aagttaaga  ctcccaggc  tgaaggcag  acacagtgc  agcaggggg  360
cgtttgccc  catgtgtaa  ggaggcagg  cccagctct  ccacggcga  gtgagctga  420
actttctga  aatagttag  gtgggtgcg  gtctgaaat  ggtactcct  ccagctatt  480
tgtacgcaa  gcctgagta  agcctgctg  tgtcatggc  acgtgtgag  aggccagcg  540
cacacggct  gctgtgacc  gtcccggag  ctgaaatgg  cctgggtct  ctccttgtc  600
tgtgattaa  gtcctctct  gaaagtgga  agcaaaggc  cacagaggt  cgcgctcac  660
agaattcct  ccggtgact  ggtaatcaa  gttactgct  tttcctttg  aggaaagac  720
acagcaaga  tctttcatt  gtctcctcc  agcctgggg  accaggctc  aactgaccc  780
ggacatcaa  ggagggatt  tgtggctgc  aaagccatc  gcccacagc  ctgttcacg  840
cttggtgct  ctctttccc  gaggctggt  ccagccagg  acacacaaa  ggcagattc  900
cgtaaacgc  gcctccctc  ctggaggct  cctcctgcc  tggatctgg  gtggagctg  960
tctgagatt  tgagttctt  tgcagagat  attaaatat  tccaagaga  attggaaaa  1020
ctgctgaac  ttttacatt  gtctgctca  cacatggct  gatgcggat  tttctataa  1080
tccagaaag  cacacagct  ctctgtatg  gaccagtgg  cgccattta  aagaacagg  1140
tgagaatct  agatatatt  ttaataaat  taatggatt  tttttttgt  aaaaaaaaa  1200
aaaaaaaa  1208



<210> 4220
<211> 591
<212> DNA
<213> Rattus norvegicus
<308> AA799406
<400> 4220

gaaaaagct  gcggccgat  ccggggagc  cggcgggtc  ccggcgcgg  gttttcctc  60
ggcctcgtc  tcccccttc  ccctccgcg  ggtcggggg  tcccggggt  cggggttct  120
ctccgcgtc  gcggttccc  cgccgggtg  gccccccgg  ccgcggttt  ccgcgcggc  180
cctcgcctc  gccggcgcc  agcagccga  ttagaactg  tgcggacca  gggaatccg  240
ctgtttaat  aaaacaaag  atcgcgaag  cccgcggcg  gtgttgacg  gatgtgatt  300
ctgcccagt  ctctgaatg  caaagtgaa  aaattcaat  aagcgcggg  aaacggcgg  360
agtaactat  actctctta  ggtagccaa  tgcctcgtc  tctaattag  gacgcgcat  420
aatggatga  cgagattcc  actgtccct  cctactatc  agcgaaacc  cagccaagg  480
aacgggctt  gcggaatca  cggggaaag  agaccctgt  gagcttgac  ctagtctgg  540
acggtgaag  gacatgaga  gtgtaaaat  agtgggagg  ccccggcgc  c  591



<210> 4221
<211> 612
<212> DNA
<213> Rattus norvegicus
<308> AA799410
<400> 4221

agaagaaga  tgagaacac  agtctttat  ttgcttttg  agaacggga  cagtccaaa  60
aaactgcct  ccatgcagt  atgcagatc  ctggtagaa  taagtcata  ctataatta  120
taaccggga  acagccttt  gaggcatat  tggagcggc  accaatggg  attggtatt  180
ccagctcaa  caggtctaa  cttctctta  atgtcagaa  ccaaggtct  ggtgtagcc  240
gtcagttgc  aagagcagc  caggaatgt  aagtggctt  aggagtctt  tggacagca  300
catcacctg  gttcctggc  tcagagatg  tacaaggtc  ttgaccatt  tggcttcag  360
aactgtgac  ccgcccacc  caaagagga  caagagggg  tggtcactg  gatggggcc  420
gctcacctt  atgaacatg  tgaatccag  tttaaggag  tcagtgagg  ctgaggaca  480
atgttcaat  tcaatggga  ctggcttct  aggattaaa  atttcttcc  caacctgct  540
caacagtgg  ttataggct  cctgatggg  actatttcc  ggaacatac  ccgatttga  600
ctgtctcag  ag  612



<210> 4222
<211> 2154
<212> DNA
<213> Homo sapiens
<308> BC012458
<400> 4222

agagcctgc  ctggggctg  ggatccacc  gtctcctgg  ggcggtggg  ggtcctgac  60
gtcacctgc  agagttcga  cccgacgca  ttggtggtg  agccaagca  cccaaggca  120
tgtttgtgc  gagctgcct  ctgaaaggc  ggaccgtgg  gatcctacg  gacatcatc  180
gccgcagtc  cttccagta  tgtgtggtg  tcacaaccg  gagccacgc  gtccacctc  240
cagctaatc  tgtcccagc  gcggcagcg  ccgagatgg  ggggcagca  ccggtgttc  300
agcagctgg  ggagaagct  tgtgaatgg  tgggcaaca  gaactacac  gccgaggtg  360
tccatgtcc  gttattgct  gcccctgtt  ctccccact  tgccttgac  ccagctttt  420
catcccttt  cccactgct  ccccaggat  tgcacctcc  taatagcgc  cgaccggac  480
agaggaagc  gggaagcct  ggtgatgtg  actccacta  gctaacccc  gagctgctg  540
tgcagatca  atgcctagt  tcaggcctc  gttctctgt  tgaacattt  ggagtacgg  600
aggagtgtt  tgctgtagg  tccttaagt  aggtcatcg  tgcggatct  gccaattat  660
cccctgcaa  gaacaggaa  aagactgct  caggcaggg  atcagtggt  tttgtggac  720
gaaccctgg  tctcacagg  gcagttgga  atcatggag  caacttagt  gagaagatc  780
tttcagcac  tccccagct  ccaggccac  caaatgatg  gatggttaa  atgatagcg  840
tcactgcac  ccatactga  gaggaaaat  ataatgtgg  tgcaccagg  tgtctttca  900
aatccagtg  caccacagc  aaagcccta  gggaagctt  actgaacac  aagcacaaa  960
aggcagtga  ggaagttcg  agacatcta  tggaagcgg  aagcagaga  aacctgcca  1020
tcaagatga  tatggggag  gtcacaccg  gacagctca  gtcctatat  cagctcttc  1080
agaacaacc  caaagctct  atgaatcat  gtggcctcc  ccagcttgg  ctggccaca  1140
ctcaaacgt  gaaacaccc  cagactgcc  agtgggaca  ctttctggc  tttgaaagg  1200
tccttcttc  gagcattgg  gagtcagca  tgtccgttg  gttaaatca  ctgctgccc  1260
tgattaagc  tgtaaccca  agaaccaac  aggactaca  ccctgagga  ctgctgatc  1320
ttctcatat  tatttattc  gtcactgga  agctcacgg  agacaaaga  ctgtgtgaa  1380
cagaagaaa  agtcaagaa  gcattggct  aggttttct  tgaggaatc  ggattgtca  1440
ctttgctgc  aaaaattac  gactgggac  cttcaatta  tctgacatt  cacaaatcc  1500
aaattgccg  ggatgaact  tttacttca  ttcgggata  tgctggagc  cggagtctc  1560
tgaaacagt  taagtctgt  tatgttcct  gaaatcata  ccaccaggc  tcttataag  1620
cattgttga  gcaagttgt  gaggaaata  ttcatcccg  gaggccaga  tccgttgat  1680
ttgaacaca  gtcttcagg  ctcactgat  tccttaaaa  tggatttag  atgttcatg  1740
aggtgagcc  gcctcatcc  agtgactac  ccctcctga  cctctttgt  gtaggtggg  1800
tcacagtct  tgaagtgaa  atggtcaaa  atcttgtgg  atcgttgaa  ccaggaacc  1860
aggtaatcg  gctgtccac  cgactcctg  agccactta  cattcctga  ctgttattt  1920
caactgacc  actgcatcc  gaccttggc  tctgagcat  cgctaagaa  ataagacct  1980
ctcaagctg  aaatgccga  gcaattttc  gccaccact  caaatactc  tccacaacc  2040
gcgtccctg  cactaattg  gagaatgat  gaattctgc  tgaagggtc  tgataccta  2100
tcagtgagg  actttgctt  gattgctgt  attcttaaa  aaaaaaaaa  aaaa  2154



<210> 4223
<211> 612
<212> DNA
<213> Rattus norvegicus
<308> AA799410
<400> 4223

agaagaaga  tgagaacac  agtctttat  ttgcttttg  agaacggga  cagtccaaa  60
aaactgcct  ccatgcagt  atgcagatc  ctggtagaa  taagtcata  ctataatta  120
taaccggga  acagccttt  gaggcatat  tggagcggc  accaatggg  attggtatt  180
ccagctcaa  caggtctaa  cttctctta  atgtcagaa  ccaaggtct  ggtgtagcc  240
gtcagttgc  aagagcagc  caggaatgt  aagtggctt  aggagtctt  tggacagca  300
catcacctg  gttcctggc  tcagagatg  tacaaggtc  ttgaccatt  tggcttcag  360
aactgtgac  ccgcccacc  caaagagga  caagagggg  tggtcactg  gatggggcc  420
gctcacctt  atgaacatg  tgaatccag  tttaaggag  tcagtgagg  ctgaggaca  480
atgttcaat  tcaatggga  ctggcttct  aggattaaa  atttcttcc  caacctgct  540
caacagtgg  ttataggct  cctgatggg  actatttcc  ggaacatac  ccgatttga  600
ctgtctcag  ag  612



<210> 4224
<211> 2154
<212> DNA
<213> Homo sapiens
<308> BC012458
<400> 4224

agagcctgc  ctggggctg  ggatccacc  gtctcctgg  ggcggtggg  ggtcctgac  60
gtcacctgc  agagttcga  cccgacgca  ttggtggtg  agccaagca  cccaaggca  120
tgtttgtgc  gagctgcct  ctgaaaggc  ggaccgtgg  gatcctacg  gacatcatc  180
gccgcagtc  cttccagta  tgtgtggtg  tcacaaccg  gagccacgc  gtccacctc  240
cagctaatc  tgtcccagc  gcggcagcg  ccgagatgg  ggggcagca  ccggtgttc  300
agcagctgg  ggagaagct  tgtgaatgg  tgggcaaca  gaactacac  gccgaggtg  360
tccatgtcc  gttattgct  gcccctgtt  ctccccact  tgccttgac  ccagctttt  420
catcccttt  cccactgct  ccccaggat  tgcacctcc  taatagcgc  cgaccggac  480
agaggaagc  gggaagcct  ggtgatgtg  actccacta  gctaacccc  gagctgctg  540
tgcagatca  atgcctagt  tcaggcctc  gttctctgt  tgaacattt  ggagtacgg  600
aggagtgtt  tgctgtagg  tccttaagt  aggtcatcg  tgcggatct  gccaattat  660
cccctgcaa  gaacaggaa  aagactgct  caggcaggg  atcagtggt  tttgtggac  720
gaaccctgg  tctcacagg  gcagttgga  atcatggag  caacttagt  gagaagatc  780
tttcagcac  tccccagct  ccaggccac  caaatgatg  gatggttaa  atgatagcg  840
tcactgcac  ccatactga  gaggaaaat  ataatgtgg  tgcaccagg  tgtctttca  900
aatccagtg  caccacagc  aaagcccta  gggaagctt  actgaacac  aagcacaaa  960
aggcagtga  ggaagttcg  agacatcta  tggaagcgg  aagcagaga  aacctgcca  1020
tcaagatga  tatggggag  gtcacaccg  gacagctca  gtcctatat  cagctcttc  1080
agaacaacc  caaagctct  atgaatcat  gtggcctcc  ccagcttgg  ctggccaca  1140
ctcaaacgt  gaaacaccc  cagactgcc  agtgggaca  ctttctggc  tttgaaagg  1200
tccttcttc  gagcattgg  gagtcagca  tgtccgttg  gttaaatca  ctgctgccc  1260
tgattaagc  tgtaaccca  agaaccaac  aggactaca  ccctgagga  ctgctgatc  1320
ttctcatat  tatttattc  gtcactgga  agctcacgg  agacaaaga  ctgtgtgaa  1380
cagaagaaa  agtcaagaa  gcattggct  aggttttct  tgaggaatc  ggattgtca  1440
ctttgctgc  aaaaattac  gactgggac  cttcaatta  tctgacatt  cacaaatcc  1500
aaattgccg  ggatgaact  tttacttca  ttcgggata  tgctggagc  cggagtctc  1560
tgaaacagt  taagtctgt  tatgttcct  gaaatcata  ccaccaggc  tcttataag  1620
cattgttga  gcaagttgt  gaggaaata  ttcatcccg  gaggccaga  tccgttgat  1680
ttgaacaca  gtcttcagg  ctcactgat  tccttaaaa  tggatttag  atgttcatg  1740
aggtgagcc  gcctcatcc  agtgactac  ccctcctga  cctctttgt  gtaggtggg  1800
tcacagtct  tgaagtgaa  atggtcaaa  atcttgtgg  atcgttgaa  ccaggaacc  1860
aggtaatcg  gctgtccac  cgactcctg  agccactta  cattcctga  ctgttattt  1920
caactgacc  actgcatcc  gaccttggc  tctgagcat  cgctaagaa  ataagacct  1980
ctcaagctg  aaatgccga  gcaattttc  gccaccact  caaatactc  tccacaacc  2040
gcgtccctg  cactaattg  gagaatgat  gaattctgc  tgaagggtc  tgataccta  2100
tcagtgagg  actttgctt  gattgctgt  attcttaaa  aaaaaaaaa  aaaa  2154



<210> 4225
<211> 621
<212> DNA
<213> Rattus norvegicus
<308> AA799421
<400> 4225

cttatttta  atgttaaga  ttcaaaatc  aagcgaggg  gtccatgag  tacaaacgc  60
cacaacttg  gcatgctca  aaaaagcta  aaccaaagc  agcaggaat  tgcaattcc  120
gagcaaacc  ccacagttg  acagcctga  catccccag  atcctccca  gaagggcgt  180
cctcggggc  ccagccctt  tggaagaaa  tctggtctc  tctcttagg  agccgggca  240
gaatggcgg  ccaggagga  tgagagaag  gaggagtca  gattccatg  ccagtgggc  300
cagccagag  tttcgtggg  tttttttct  tgtaataaa  gaactgaag  tgcttcagg  360
ttgtgggtg  acggctact  cagacctag  actgcacac  gagcagacg  agttcaaat  420
tgtgatctt  gtgagtctg  accaaagag  gccttctgg  cactgggag  gtggggaag  480
acagggcct  ggatgaggg  atgcaataa  taagagagc  gatgtggga  tggggctct  540
gggaggacg  atagttcga  acattctga  cctctgcaa  acgggattg  ctcaacacc  600
tccttgcag  gagctaact  c  621



<210> 4226
<211> 737
<212> PRT
<213> Rattus norvegicus
<308> KIRTCE
<400> 4226

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
  1               5                  10                  15
Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
             20                  25                  30
Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
         35                  40                  45
Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
     50                  55                  60
Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
 65                  70                  75                  80
Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                 85                  90                  95
Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
             100                105                110
Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Lys Val Tyr Val Ile 
         115                120                125
Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
     130                135                140
Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
 145                150                155                160
Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                 165                170                175
Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
             180                185                190
Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
         195                200                205
His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
     210                215                220
Lys Gln Glu Thr Pro Asp Glu Val Gly Ser Gln Arg Phe Ser Val Asn 
 225                230                235                240
Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                 245                250                255
Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
             260                265                270
Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
         275                280                285
Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
     290                295                300
Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
 305                310                315                320
Lys Lys Leu Ala Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Asn 
                 325                330                335
Ser Pro Ser Glu Asp Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
             340                345                350
Asp Gln Glu Leu Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
         355                360                365
Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ser Ser Ser Thr Asp Gly 
     370                375                380
Gln Leu Ala Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
 385                390                395                400
Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                 405                410                415
Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
             420                425                430
Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
         435                440                445
Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
     450                455                460
Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
 465                470                475                480
Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                 485                490                495
Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Gly Phe Tyr 
             500                505                510
Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
         515                520                525
Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
     530                535                540
His Ser Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
 545                550                555                560
Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                 565                570                575
Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
             580                585                590
Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
         595                600                605
Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
     610                615                620
Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
 625                630                635                640
Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ala Gln 
                 645                650                655
Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
             660                665                670
Trp Val Leu Leu Glu Gln Lys Lys Met Lys Pro Pro Phe Lys Pro Arg 
         675                680                685
Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
     690                695                700
Glu Glu Pro Ile Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
 705                710                715                720
Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                 725                730                735
Pro 
             740



<210> 4227
<211> 2244
<212> DNA
<213> Homo sapiens
<308> X65293
<400> 4227

ctccccgcc  cgaccatgg  agtgttcaa  ggccttctt  agatcaaaa  ctgcgaggc  60
gtgagcttg  agcccacag  ctggtcgct  cgccatgcg  tgggacccc  gccgcagac  120
ttccttctc  acccctaca  tgccctcaa  gtggacgac  cgcgcatcg  ccaaacggc  180
accaagcag  agaccaaca  cccggcctg  cacgacgag  tcgtcaccg  tgtgtgcaa  240
ggacgcaag  tcgagctgg  tgtctttca  gatgccccc  taggctacg  cgacttcgt  300
gccaactgc  ccatccagt  tgaggagct  ctgcagaac  ggagccgcc  cttcgagga  360
tggattgat  tggagccag  aggaagagt  tatgtgatc  tcgatctct  agggtcgtc  420
ggtgaagcc  ctaaagaca  tgaagagcg  gtgttcagg  aacgcatgc  gccgaggaa  480
cggcagggg  ccgtcaggc  cagggtcca  caggtcaac  gccacaagt  catggccac  540
tatcttcgg  agcccacct  ctgctccca  tgcagagac  tcatctggg  tgtcatagg  600
aagcaggga  accagtgtc  agtctgcac  tgcgtggtc  acaagcggt  ccacgagct  660
ataatcaca  agtgtgctg  gttaaagaa  caggagacc  ccgaccagg  gggctccca  720
cggttcagc  tcaacatgc  ccacaagtt  ggtatccac  actacaagg  ccctacctt  780
tgcgatcac  gtgggtccc  gctctgggg  ctcttgcgg  agggtttgc  gtgtaaagt  840
tgcaaaatg  atgttcacc  tcgatgtga  accaacgtg  ctcccaact  tggagtgga  900
gccagagga  tcgccaaag  actggccga  ctgggcgtt  ccccagaca  aatcaccaa  960
agcggccag  gaaggaaaa  gctcattgc  ggtgccgag  ccccgcagc  tgcttctgg  1020
agctcacca  ctgaggaag  tcgatccaa  tcagcaccc  cctcccctt  tgaccagga  1080
ataaaagaa  ttgagaaca  cattcggaa  gccttgtca  ttgacaacc  aggagagga  1140
caccgggca  catcgtctc  tgatggcca  ctgatgagc  ccggtgaga  tggcgaagt  1200
cggcaaggc  aggccaagc  cctgggcct  gatgagttc  acttcatca  ggtgttggg  1260
aaaggcagc  ttggcaagg  catgttggc  gaactcaag  gcaaagatg  agtatatgc  1320
gtgaaggtc  taaagaagg  cgtcatcct  caggatgat  acgtggact  cacaatgac  1380
gagaagagg  ttttggctc  ggcacggaa  cacccgtac  ttacccaac  ctactgctg  1440
ttccagacc  aggaccgcc  ctttttcgt  atggaatat  taaatggtg  agacctcat  1500
tttcagatt  agcgctccc  aaaattcga  gagcctcgt  cacggttct  tgctgcaga  1560
gtcacatcg  ccctcatgt  cctccatca  catggagtc  tctacaggg  tttgaaact  1620
gacaacatc  ttctggatg  agaaggtca  tgcaagctg  ctgacttcg  gatgtgcaa  1680
gaagggatt  tgaatggtg  gacgaccac  acgttctgt  ggactcctg  ctacatagc  1740
cctgagatc  tgcaggagt  ggagtatgg  ccctccgtg  actggtggg  cctgggggt  1800
ctgatgtac  agatgatgg  tggacagcc  ccctttgag  ccgacaatg  ggacgacct  1860
tttgagtcc  tcctccatg  cgacgtgct  tacccagtc  ggctcagca  ggaggctgt  1920
agcatcttg  aagctttca  gacgaagaa  ccccacaag  gcctgggct  tgtggcatc  1980
cagaatggc  aggacgcca  caagcagca  ccattcttc  aagagattg  ctgggtgct  2040
ctggagcag  agaagatca  gccaccctt  aaaccacgc  ttaaaacca  aagagacgt  2100
aataatttt  accaagact  tacccggga  gagccggta  tcacccttg  ggacgaagc  2160
attgtaaag  agatcaacc  ggaggaatt  aaaggtttc  cctactttg  tgaagacct  2220
atgccctga  agcccactg  agtt  2244



<210> 4228
<211> 737
<212> PRT
<213> Homo sapiens
<308> Q02156
<400> 4228

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
  1               5                  10                  15
Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
             20                  25                  30
Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
         35                  40                  45
Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
     50                  55                  60
Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
 65                  70                  75                  80
Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                 85                  90                  95
Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
             100                105                110
Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Arg Val Tyr Val Ile 
         115                120                125
Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
     130                135                140
Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
 145                150                155                160
Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                 165                170                175
Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
             180                185                190
Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
         195                200                205
His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
     210                215                220
Lys Gln Glu Thr Pro Asp Gln Val Gly Ser Gln Arg Phe Ser Val Asn 
 225                230                235                240
Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                 245                250                255
Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
             260                265                270
Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
         275                280                285
Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
     290                295                300
Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
 305                310                315                320
Lys Lys Leu Ile Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Ser 
                 325                330                335
Ser Pro Ser Glu Glu Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
             340                345                350
Asp Gln Glu Ile Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
         355                360                365
Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ala Ser Ser Pro Asp Gly 
     370                375                380
Gln Leu Met Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
 385                390                395                400
Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                 405                410                415
Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
             420                425                430
Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
         435                440                445
Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
     450                455                460
Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
 465                470                475                480
Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                 485                490                495
Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Arg Phe Tyr 
             500                505                510
Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
         515                520                525
Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
     530                535                540
His Cys Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
 545                550                555                560
Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                 565                570                575
Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
             580                585                590
Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
         595                600                605
Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
     610                615                620
Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
 625                630                635                640
Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ser Gln 
                 645                650                655
Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
             660                665                670
Trp Val Leu Leu Glu Gln Lys Lys Ile Lys Pro Pro Phe Lys Pro Arg 
         675                680                685
Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
     690                695                700
Glu Glu Pro Val Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
 705                710                715                720
Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                 725                730                735
Pro 
             740



<210> 4229
<211> 774
<212> DNA
<213> Rattus norvegicus
<308> AB049641
<400> 4229

gagagcatg  ccagcttct  tagggcgcc  cagcaatgg  ccacttttg  tcgaatgtg  60
tatctctta  atggcaaaa  gcagccccc  ggcaaactt  cggttatag  atccaacaa  120
ctgcaagga  taaataaac  agtgtacca  cagctgagt  actgtggag  ccacgttgt  180
ataataaac  caagacata  tgcattttc  ggaaacaaa  gggaacaaa  agtgtactc  240
tcacatact  gctacccag  cggctttag  caagtaaca  ctgcgcagc  tcaccggaa  300
gaccccgtg  cgattgtga  attggctat  tatggcatg  tgcccaaaa  cctgcacag  360
aggacaatg  tgcaaaggc  gcatctttt  ccagacgag  atattccgg  agatattct  420
aagaattta  tggaagagc  tcctcagcc  cggagagtg  ctaaacggc  ggacgagta  480
acccaagaa  aaatagagg  tttccccag  gtgtggact  cacctgatg  ttttcggat  540
taggagaat  gaaatgata  aacattaca  caagagact  aatgtttcc  gaagtatta  600
catgaccca  ggcagagag  aaccatggg  actccctgt  gggaacact  aagaaggcc  660
agcctcagc  ggaaagtgc  gtagaagat  ctgttttac  gacaagtcc  gtgtaacct  720
ctttaaatg  tacacatgt  aataaaatg  ttatttggt  agctaaaaa  aaaa  774



<210> 4230
<211> 178
<212> PRT
<213> Rattus norvegicus
<308> BAB40846
<400> 4230

Met Ser Ser Phe Ser Arg Ala Pro Gln Gln Trp Ala Thr Phe Ala Arg 
  1               5                  10                  15
Met Trp Tyr Leu Leu Asp Gly Lys Met Gln Pro Pro Gly Lys Leu Ala 
             20                  25                  30
Val Ile Ala Ser Asn Lys Leu Gln Gly Leu Asn Lys Pro Val Tyr His 
         35                  40                  45
Gln Leu Ser Asp Cys Gly Asp His Val Val Ile Ile Asn Thr Arg His 
     50                  55                  60
Ile Ala Phe Ser Gly Asn Lys Trp Glu Gln Lys Val Tyr Ser Ser His 
 65                  70                  75                  80
Thr Gly Tyr Pro Gly Gly Phe Arg Gln Val Thr Ala Ala Gln Leu His 
                 85                  90                  95
Arg Lys Asp Pro Val Ala Ile Val Lys Leu Ala Ile Tyr Gly Met Leu 
             100                105                110
Pro Lys Asn Leu His Arg Arg Thr Met Met Gln Arg Leu His Leu Phe 
         115                120                125
Pro Asp Glu Asp Ile Pro Glu Asp Ile Leu Lys Asn Leu Val Glu Glu 
     130                135                140
Leu Pro Gln Pro Arg Arg Val Pro Lys Arg Leu Asp Glu Tyr Thr Gln 
 145                150                155                160
Glu Glu Ile Glu Ala Phe Pro Arg Val Trp Thr Pro Pro Asp Asp Phe 
                 165                170                175
Arg Met 
             180



<210> 4231
<211> 1086
<212> DNA
<213> Homo sapiens
<308> NM_014078
<400> 4231

gtcggctgg  aattatgtc  tccgtcggt  ttccgcagt  tttccacca  gcgagatat  60
tttgggagt  attccctaa  taactgcat  atatgctcc  ttcatgacg  aattgctgc  120
gtggagaag  ctggaggaa  ctcgaggaa  agggagaag  cgacaagtg  tcgacgggc  180
aggaactgt  ctgcttggg  gttagcgtt  cccgccggg  cagtaaggc  gagtgaccc  240
gcgtggcta  taggagaag  acgtacggt  ctgctagta  aggaatatg  cgagtttct  300
tagggcgcc  cagcaatgg  ccacttttg  tagaatatg  tatctctta  atgggaaaa  360
gcagccacc  ggcaaactt  ctgctatgg  atctataag  cttcaggga  tacataaac  420
tgtgtacca  gcactgagt  actgtgggg  tcatgttgt  ataatgaac  caagacaca  480
tgcattttc  ggaaacaaa  gggaacaaa  agtatactc  tcgcatact  gctacccag  540
tggatttag  caagtaaca  ctgctcagc  tcacctgag  gatccagtg  caattgtaa  600
actagctat  tatggcatg  tgccaaaaa  ccttcacag  agaacaatg  tggaaaggt  660
gcatctttt  ccagatgag  atattccag  agatattct  aagaattta  tagaggagc  720
tcctcaacc  cgaaaaata  ctaaacgtc  agatgagta  acacaagaa  aaatagacg  780
cttcccaag  ttgtggact  cacctgaag  ttatcggct  taagagaat  agaattgca  840
aaaataaca  tgaagtgat  gaaactttc  tctgatgag  ttctctaac  tacaggatg  900
agtaaaaca  ctgctacag  tcagcacct  ttttatgtg  cgaatcact  tggggaaag  960
tcaggaagg  atagtcctt  aataggaaa  tgtaattaa  atataattt  atagaacca  1020
ttttatgta  tctgatttg  atgttatag  tgataataa  aaaatcact  acttggttg  1080
ctaaaa  1086



<210> 4232
<211> 178
<212> PRT
<213> Homo sapiens
<308> NP_054797
<400> 4232

Met Ser Ser Phe Ser Arg Ala Pro Gln Gln Trp Ala Thr Phe Ala Arg 
  1               5                  10                  15
Ile Trp Tyr Leu Leu Asp Gly Lys Met Gln Pro Pro Gly Lys Leu Ala 
             20                  25                  30
Ala Met Ala Ser Ile Arg Leu Gln Gly Leu His Lys Pro Val Tyr His 
         35                  40                  45
Ala Leu Ser Asp Cys Gly Asp His Val Val Ile Met Asn Thr Arg His 
     50                  55                  60
Ile Ala Phe Ser Gly Asn Lys Trp Glu Gln Lys Val Tyr Ser Ser His 
 65                  70                  75                  80
Thr Gly Tyr Pro Gly Gly Phe Arg Gln Val Thr Ala Ala Gln Leu His 
                 85                  90                  95
Leu Arg Asp Pro Val Ala Ile Val Lys Leu Ala Ile Tyr Gly Met Leu 
             100                105                110
Pro Lys Asn Leu His Arg Arg Thr Met Met Glu Arg Leu His Leu Phe 
         115                120                125
Pro Asp Glu Tyr Ile Pro Glu Asp Ile Leu Lys Asn Leu Val Glu Glu 
     130                135                140
Leu Pro Gln Pro Arg Lys Ile Pro Lys Arg Leu Asp Glu Tyr Thr Gln 
 145                150                155                160
Glu Glu Ile Asp Ala Phe Pro Arg Leu Trp Thr Pro Pro Glu Asp Tyr 
                 165                170                175
Arg Leu 
             180



<210> 4233
<211> 649
<212> DNA
<213> Rattus norvegicus
<308> AA799442
<400> 4233

actgaggat  tcataatgc  aggtgaaag  agcagagtt  cttttcact  ttacaccag  60
gccaaagac  ttttataaa  aggttcatt  tactgaact  gcctccact  attcttggg  120
taatcatca  gcacaattc  tgcatatgc  ttttcacat  cagcatagt  atataagcc  180
ttaaacact  caatattat  tgaaacaac  gaggaacgg  cattgcttt  atcccagtt  240
gacaaagga  taaccaatg  agcataact  ttccctttg  cggcactgg  acagtgtga  300
acttaactg  taagcgtcc  tttttataa  aagccaaag  actgggata  gagacccca  360
aggctacgc  gatcagtga  cttctcaga  cacagcttt  ctggcttat  ttacctgat  420
gcagagcat  agtcacaaa  agcttgtaa  taacggcgg  agccacaaa  ggaagggta  480
tcagggatg  ataggtcct  aaagcttca  acntaacct  gaaactgta  ctgaatact  540
gtttgccca  acgcagaca  ctactacta  tcaanngat  agttcacgt  natttaaat  600
tggtcgttn  ntagatcaa  cttctctca  agattcaac  atatgggct  649



<210> 4234
<211> 1172
<212> DNA
<213> Homo sapiens
<308> NM_018480
<400> 4234

aaaatggtg  tgttcgggt  tgaggctgg  actaagcca  gggattcag  tgtggtgcc  60
gtgggaact  aggaagcgc  caaggaaat  aaacacgat  tccaaaatg  acttaatct  120
tcatgagaa  ctgaggata  agatgtcaa  aagcagcca  tgtttccac  tccccacct  180
aagagctag  agcgcccaa  ctttcggtt  tgagctcgg  ctaagccat  tggattcag  240
tgtggatga  ggtgggaac  gaggaagcg  ccaaggttt  caagatggc  gcatctatg  300
atggtcagc  cagtccttc  ctagaagat  caaaactca  aagaccaat  gtcatagaa  360
tcatagaaa  aaattttga  tatcttaga  aagaaatga  acaaaatat  tatcaaatg  420
cgacatttg  aacaacagc  ggtttctct  gaatattct  aaacttcct  ttcagacgc  480
gcttcaagg  taaacatga  gctttgaag  catatgcat  attggctac  cttccattt  540
tgtctactg  tgttactga  aagcttttt  taattgatg  tttgtattc  gataatata  600
gcaaggaaa  ctgtgtttt  agaagctca  tgattggca  agtttgtgg  gttttctat  660
ccagttctt  ggcttttac  aaaaatgga  gcctggcaa  caagtatca  accgttcca  720
tgccaccaa  aggaagggt  ttaatccat  ggatgacgc  ttgtcaaac  caaatgaaa  780
taatggcga  tcctctagt  tttcagatt  tgtttggaa  attaaatgg  ctataccat  840
atgcagtat  tgaagagac  cttgagaaa  ctatacatg  agagtaacc  aaaaaatga  900
tggttgcta  cttagcaaa  tgaagtttc  ataaagagg  ctcaggcat  gctgaaaga  960
ttaaaagta  ctgtgaaca  ataatttgt  ctgtgcctt  tgcctggta  atagcaaat  1020
ctcaaaaag  attcaataa  tcaatcaat  aatataagt  tcatcttac  cgtaagata  1080
aggtcttat  tcctgatgg  gtgtccatt  tgcctggta  ataacagat  ataaatatc  1140
agtgtcaat  aatgtaaca  taaaaaaaa  aa  1172



<210> 4235
<211> 649
<212> DNA
<213> Rattus norvegicus
<308> AA799442
<400> 4235

actgaggat  tcataatgc  aggtgaaag  agcagagtt  cttttcact  ttacaccag  60
gccaaagac  ttttataaa  aggttcatt  tactgaact  gcctccact  attcttggg  120
taatcatca  gcacaattc  tgcatatgc  ttttcacat  cagcatagt  atataagcc  180
ttaaacact  caatattat  tgaaacaac  gaggaacgg  cattgcttt  atcccagtt  240
gacaaagga  taaccaatg  agcataact  ttccctttg  cggcactgg  acagtgtga  300
acttaactg  taagcgtcc  tttttataa  aagccaaag  actgggata  gagacccca  360
aggctacgc  gatcagtga  cttctcaga  cacagcttt  ctggcttat  ttacctgat  420
gcagagcat  agtcacaaa  agcttgtaa  taacggcgg  agccacaaa  ggaagggta  480
tcagggatg  ataggtcct  aaagcttca  acntaacct  gaaactgta  ctgaatact  540
gtttgccca  acgcagaca  ctactacta  tcaanngat  agttcacgt  natttaaat  600
tggtcgttn  ntagatcaa  cttctctca  agattcaac  atatgggct  649



<210> 4236
<211> 1172
<212> DNA
<213> Homo sapiens
<308> NM_018480
<400> 4236

aaaatggtg  tgttcgggt  tgaggctgg  actaagcca  gggattcag  tgtggtgcc  60
gtgggaact  aggaagcgc  caaggaaat  aaacacgat  tccaaaatg  acttaatct  120
tcatgagaa  ctgaggata  agatgtcaa  aagcagcca  tgtttccac  tccccacct  180
aagagctag  agcgcccaa  ctttcggtt  tgagctcgg  ctaagccat  tggattcag  240
tgtggatga  ggtgggaac  gaggaagcg  ccaaggttt  caagatggc  gcatctatg  300
atggtcagc  cagtccttc  ctagaagat  caaaactca  aagaccaat  gtcatagaa  360
tcatagaaa  aaattttga  tatcttaga  aagaaatga  acaaaatat  tatcaaatg  420
cgacatttg  aacaacagc  ggtttctct  gaatattct  aaacttcct  ttcagacgc  480
gcttcaagg  taaacatga  gctttgaag  catatgcat  attggctac  cttccattt  540
tgtctactg  tgttactga  aagcttttt  taattgatg  tttgtattc  gataatata  600
gcaaggaaa  ctgtgtttt  agaagctca  tgattggca  agtttgtgg  gttttctat  660
ccagttctt  ggcttttac  aaaaatgga  gcctggcaa  caagtatca  accgttcca  720
tgccaccaa  aggaagggt  ttaatccat  ggatgacgc  ttgtcaaac  caaatgaaa  780
taatggcga  tcctctagt  tttcagatt  tgtttggaa  attaaatgg  ctataccat  840
atgcagtat  tgaagagac  cttgagaaa  ctatacatg  agagtaacc  aaaaaatga  900
tggttgcta  cttagcaaa  tgaagtttc  ataaagagg  ctcaggcat  gctgaaaga  960
ttaaaagta  ctgtgaaca  ataatttgt  ctgtgcctt  tgcctggta  atagcaaat  1020
ctcaaaaag  attcaataa  tcaatcaat  aatataagt  tcatcttac  cgtaagata  1080
aggtcttat  tcctgatgg  gtgtccatt  tgcctggta  ataacagat  ataaatatc  1140
agtgtcaat  aatgtaaca  taaaaaaaa  aa  1172



<210> 4237
<211> 649
<212> DNA
<213> Rattus norvegicus
<308> AA799442
<400> 4237

actgaggat  tcataatgc  aggtgaaag  agcagagtt  cttttcact  ttacaccag  60
gccaaagac  ttttataaa  aggttcatt  tactgaact  gcctccact  attcttggg  120
taatcatca  gcacaattc  tgcatatgc  ttttcacat  cagcatagt  atataagcc  180
ttaaacact  caatattat  tgaaacaac  gaggaacgg  cattgcttt  atcccagtt  240
gacaaagga  taaccaatg  agcataact  ttccctttg  cggcactgg  acagtgtga  300
acttaactg  taagcgtcc  tttttataa  aagccaaag  actgggata  gagacccca  360
aggctacgc  gatcagtga  cttctcaga  cacagcttt  ctggcttat  ttacctgat  420
gcagagcat  agtcacaaa  agcttgtaa  taacggcgg  agccacaaa  ggaagggta  480
tcagggatg  ataggtcct  aaagcttca  acntaacct  gaaactgta  ctgaatact  540
gtttgccca  acgcagaca  ctactacta  tcaanngat  agttcacgt  natttaaat  600
tggtcgttn  ntagatcaa  cttctctca  agattcaac  atatgggct  649



<210> 4238
<211> 1172
<212> DNA
<213> Homo sapiens
<308> NM_018480
<400> 4238

aaaatggtg  tgttcgggt  tgaggctgg  actaagcca  gggattcag  tgtggtgcc  60
gtgggaact  aggaagcgc  caaggaaat  aaacacgat  tccaaaatg  acttaatct  120
tcatgagaa  ctgaggata  agatgtcaa  aagcagcca  tgtttccac  tccccacct  180
aagagctag  agcgcccaa  ctttcggtt  tgagctcgg  ctaagccat  tggattcag  240
tgtggatga  ggtgggaac  gaggaagcg  ccaaggttt  caagatggc  gcatctatg  300
atggtcagc  cagtccttc  ctagaagat  caaaactca  aagaccaat  gtcatagaa  360
tcatagaaa  aaattttga  tatcttaga  aagaaatga  acaaaatat  tatcaaatg  420
cgacatttg  aacaacagc  ggtttctct  gaatattct  aaacttcct  ttcagacgc  480
gcttcaagg  taaacatga  gctttgaag  catatgcat  attggctac  cttccattt  540
tgtctactg  tgttactga  aagcttttt  taattgatg  tttgtattc  gataatata  600
gcaaggaaa  ctgtgtttt  agaagctca  tgattggca  agtttgtgg  gttttctat  660
ccagttctt  ggcttttac  aaaaatgga  gcctggcaa  caagtatca  accgttcca  720
tgccaccaa  aggaagggt  ttaatccat  ggatgacgc  ttgtcaaac  caaatgaaa  780
taatggcga  tcctctagt  tttcagatt  tgtttggaa  attaaatgg  ctataccat  840
atgcagtat  tgaagagac  cttgagaaa  ctatacatg  agagtaacc  aaaaaatga  900
tggttgcta  cttagcaaa  tgaagtttc  ataaagagg  ctcaggcat  gctgaaaga  960
ttaaaagta  ctgtgaaca  ataatttgt  ctgtgcctt  tgcctggta  atagcaaat  1020
ctcaaaaag  attcaataa  tcaatcaat  aatataagt  tcatcttac  cgtaagata  1080
aggtcttat  tcctgatgg  gtgtccatt  tgcctggta  ataacagat  ataaatatc  1140
agtgtcaat  aatgtaaca  taaaaaaaa  aa  1172



<210> 4239
<211> 219
<212> PRT
<213> Homo sapiens
<308> AAF67658
<400> 4239

Met Trp Ile Gln Val Trp Met Thr Val Gly Thr Glu Glu Ala Pro Lys 
  1               5                  10                  15
Val Phe Lys Met Ala Ala Ser Met His Gly Gln Pro Ser Pro Ser Leu 
             20                  25                  30
Glu Asp Ala Lys Leu Arg Arg Pro Met Val Ile Glu Ile Ile Glu Lys 
         35                  40                  45
Asn Phe Asp Tyr Leu Arg Lys Glu Met Thr Gln Asn Ile Tyr Gln Met 
     50                  55                  60
Ala Thr Phe Gly Thr Thr Ala Gly Phe Ser Gly Ile Phe Ser Asn Phe 
 65                  70                  75                  80
Leu Phe Arg Arg Cys Phe Lys Val Lys His Asp Ala Leu Lys Thr Tyr 
                 85                  90                  95
Ala Ser Leu Ala Thr Leu Pro Phe Leu Ser Thr Val Val Thr Asp Lys 
             100                105                110
Leu Phe Val Ile Asp Ala Leu Tyr Ser Asp Asn Ile Ser Lys Glu Asn 
         115                120                125
Cys Val Phe Arg Ser Ser Leu Ile Gly Ile Val Cys Gly Val Phe Tyr 
     130                135                140
Pro Ser Ser Leu Ala Phe Thr Lys Asn Gly Arg Leu Ala Thr Lys Tyr 
 145                150                155                160
His Thr Val Pro Leu Pro Pro Lys Gly Arg Val Leu Ile His Trp Met 
                 165                170                175
Thr Leu Cys Gln Thr Gln Met Lys Leu Met Ala Ile Pro Leu Val Phe 
             180                185                190
Gln Ile Met Phe Gly Ile Leu Asn Gly Leu Tyr His Tyr Ala Val Phe 
         195                200                205
Glu Glu Thr Leu Glu Lys Thr Ile His Glu Glu 
     210                215



<210> 4240
<211> 649
<212> DNA
<213> Rattus norvegicus
<308> AA799442
<400> 4240

actgaggat  tcataatgc  aggtgaaag  agcagagtt  cttttcact  ttacaccag  60
gccaaagac  ttttataaa  aggttcatt  tactgaact  gcctccact  attcttggg  120
taatcatca  gcacaattc  tgcatatgc  ttttcacat  cagcatagt  atataagcc  180
ttaaacact  caatattat  tgaaacaac  gaggaacgg  cattgcttt  atcccagtt  240
gacaaagga  taaccaatg  agcataact  ttccctttg  cggcactgg  acagtgtga  300
acttaactg  taagcgtcc  tttttataa  aagccaaag  actgggata  gagacccca  360
aggctacgc  gatcagtga  cttctcaga  cacagcttt  ctggcttat  ttacctgat  420
gcagagcat  agtcacaaa  agcttgtaa  taacggcgg  agccacaaa  ggaagggta  480
tcagggatg  ataggtcct  aaagcttca  acntaacct  gaaactgta  ctgaatact  540
gtttgccca  acgcagaca  ctactacta  tcaanngat  agttcacgt  natttaaat  600
tggtcgttn  ntagatcaa  cttctctca  agattcaac  atatgggct  649



<210> 4241
<211> 1172
<212> DNA
<213> Homo sapiens
<308> NM_018480
<400> 4241

aaaatggtg  tgttcgggt  tgaggctgg  actaagcca  gggattcag  tgtggtgcc  60
gtgggaact  aggaagcgc  caaggaaat  aaacacgat  tccaaaatg  acttaatct  120
tcatgagaa  ctgaggata  agatgtcaa  aagcagcca  tgtttccac  tccccacct  180
aagagctag  agcgcccaa  ctttcggtt  tgagctcgg  ctaagccat  tggattcag  240
tgtggatga  ggtgggaac  gaggaagcg  ccaaggttt  caagatggc  gcatctatg  300
atggtcagc  cagtccttc  ctagaagat  caaaactca  aagaccaat  gtcatagaa  360
tcatagaaa  aaattttga  tatcttaga  aagaaatga  acaaaatat  tatcaaatg  420
cgacatttg  aacaacagc  ggtttctct  gaatattct  aaacttcct  ttcagacgc  480
gcttcaagg  taaacatga  gctttgaag  catatgcat  attggctac  cttccattt  540
tgtctactg  tgttactga  aagcttttt  taattgatg  tttgtattc  gataatata  600
gcaaggaaa  ctgtgtttt  agaagctca  tgattggca  agtttgtgg  gttttctat  660
ccagttctt  ggcttttac  aaaaatgga  gcctggcaa  caagtatca  accgttcca  720
tgccaccaa  aggaagggt  ttaatccat  ggatgacgc  ttgtcaaac  caaatgaaa  780
taatggcga  tcctctagt  tttcagatt  tgtttggaa  attaaatgg  ctataccat  840
atgcagtat  tgaagagac  cttgagaaa  ctatacatg  agagtaacc  aaaaaatga  900
tggttgcta  cttagcaaa  tgaagtttc  ataaagagg  ctcaggcat  gctgaaaga  960
ttaaaagta  ctgtgaaca  ataatttgt  ctgtgcctt  tgcctggta  atagcaaat  1020
ctcaaaaag  attcaataa  tcaatcaat  aatataagt  tcatcttac  cgtaagata  1080
aggtcttat  tcctgatgg  gtgtccatt  tgcctggta  ataacagat  ataaatatc  1140
agtgtcaat  aatgtaaca  taaaaaaaa  aa  1172



<210> 4242
<211> 649
<212> DNA
<213> Rattus norvegicus
<308> AA799442
<400> 4242

actgaggat  tcataatgc  aggtgaaag  agcagagtt  cttttcact  ttacaccag  60
gccaaagac  ttttataaa  aggttcatt  tactgaact  gcctccact  attcttggg  120
taatcatca  gcacaattc  tgcatatgc  ttttcacat  cagcatagt  atataagcc  180
ttaaacact  caatattat  tgaaacaac  gaggaacgg  cattgcttt  atcccagtt  240
gacaaagga  taaccaatg  agcataact  ttccctttg  cggcactgg  acagtgtga  300
acttaactg  taagcgtcc  tttttataa  aagccaaag  actgggata  gagacccca  360
aggctacgc  gatcagtga  cttctcaga  cacagcttt  ctggcttat  ttacctgat  420
gcagagcat  agtcacaaa  agcttgtaa  taacggcgg  agccacaaa  ggaagggta  480
tcagggatg  ataggtcct  aaagcttca  acntaacct  gaaactgta  ctgaatact  540
gtttgccca  acgcagaca  ctactacta  tcaanngat  agttcacgt  natttaaat  600
tggtcgttn  ntagatcaa  cttctctca  agattcaac  atatgggct  649



<210> 4243
<211> 1172
<212> DNA
<213> Homo sapiens
<308> NM_018480
<400> 4243

aaaatggtg  tgttcgggt  tgaggctgg  actaagcca  gggattcag  tgtggtgcc  60
gtgggaact  aggaagcgc  caaggaaat  aaacacgat  tccaaaatg  acttaatct  120
tcatgagaa  ctgaggata  agatgtcaa  aagcagcca  tgtttccac  tccccacct  180
aagagctag  agcgcccaa  ctttcggtt  tgagctcgg  ctaagccat  tggattcag  240
tgtggatga  ggtgggaac  gaggaagcg  ccaaggttt  caagatggc  gcatctatg  300
atggtcagc  cagtccttc  ctagaagat  caaaactca  aagaccaat  gtcatagaa  360
tcatagaaa  aaattttga  tatcttaga  aagaaatga  acaaaatat  tatcaaatg  420
cgacatttg  aacaacagc  ggtttctct  gaatattct  aaacttcct  ttcagacgc  480
gcttcaagg  taaacatga  gctttgaag  catatgcat  attggctac  cttccattt  540
tgtctactg  tgttactga  aagcttttt  taattgatg  tttgtattc  gataatata  600
gcaaggaaa  ctgtgtttt  agaagctca  tgattggca  agtttgtgg  gttttctat  660
ccagttctt  ggcttttac  aaaaatgga  gcctggcaa  caagtatca  accgttcca  720
tgccaccaa  aggaagggt  ttaatccat  ggatgacgc  ttgtcaaac  caaatgaaa  780
taatggcga  tcctctagt  tttcagatt  tgtttggaa  attaaatgg  ctataccat  840
atgcagtat  tgaagagac  cttgagaaa  ctatacatg  agagtaacc  aaaaaatga  900
tggttgcta  cttagcaaa  tgaagtttc  ataaagagg  ctcaggcat  gctgaaaga  960
ttaaaagta  ctgtgaaca  ataatttgt  ctgtgcctt  tgcctggta  atagcaaat  1020
ctcaaaaag  attcaataa  tcaatcaat  aatataagt  tcatcttac  cgtaagata  1080
aggtcttat  tcctgatgg  gtgtccatt  tgcctggta  ataacagat  ataaatatc  1140
agtgtcaat  aatgtaaca  taaaaaaaa  aa  1172



<210> 4244
<211> 649
<212> DNA
<213> Rattus norvegicus
<308> AA799442
<400> 4244

actgaggat  tcataatgc  aggtgaaag  agcagagtt  cttttcact  ttacaccag  60
gccaaagac  ttttataaa  aggttcatt  tactgaact  gcctccact  attcttggg  120
taatcatca  gcacaattc  tgcatatgc  ttttcacat  cagcatagt  atataagcc  180
ttaaacact  caatattat  tgaaacaac  gaggaacgg  cattgcttt  atcccagtt  240
gacaaagga  taaccaatg  agcataact  ttccctttg  cggcactgg  acagtgtga  300
acttaactg  taagcgtcc  tttttataa  aagccaaag  actgggata  gagacccca  360
aggctacgc  gatcagtga  cttctcaga  cacagcttt  ctggcttat  ttacctgat  420
gcagagcat  agtcacaaa  agcttgtaa  taacggcgg  agccacaaa  ggaagggta  480
tcagggatg  ataggtcct  aaagcttca  acntaacct  gaaactgta  ctgaatact  540
gtttgccca  acgcagaca  ctactacta  tcaanngat  agttcacgt  natttaaat  600
tggtcgttn  ntagatcaa  cttctctca  agattcaac  atatgggct  649



<210> 4245
<211> 1172
<212> DNA
<213> Homo sapiens
<308> NM_018480
<400> 4245

aaaatggtg  tgttcgggt  tgaggctgg  actaagcca  gggattcag  tgtggtgcc  60
gtgggaact  aggaagcgc  caaggaaat  aaacacgat  tccaaaatg  acttaatct  120
tcatgagaa  ctgaggata  agatgtcaa  aagcagcca  tgtttccac  tccccacct  180
aagagctag  agcgcccaa  ctttcggtt  tgagctcgg  ctaagccat  tggattcag  240
tgtggatga  ggtgggaac  gaggaagcg  ccaaggttt  caagatggc  gcatctatg  300
atggtcagc  cagtccttc  ctagaagat  caaaactca  aagaccaat  gtcatagaa  360
tcatagaaa  aaattttga  tatcttaga  aagaaatga  acaaaatat  tatcaaatg  420
cgacatttg  aacaacagc  ggtttctct  gaatattct  aaacttcct  ttcagacgc  480
gcttcaagg  taaacatga  gctttgaag  catatgcat  attggctac  cttccattt  540
tgtctactg  tgttactga  aagcttttt  taattgatg  tttgtattc  gataatata  600
gcaaggaaa  ctgtgtttt  agaagctca  tgattggca  agtttgtgg  gttttctat  660
ccagttctt  ggcttttac  aaaaatgga  gcctggcaa  caagtatca  accgttcca  720
tgccaccaa  aggaagggt  ttaatccat  ggatgacgc  ttgtcaaac  caaatgaaa  780
taatggcga  tcctctagt  tttcagatt  tgtttggaa  attaaatgg  ctataccat  840
atgcagtat  tgaagagac  cttgagaaa  ctatacatg  agagtaacc  aaaaaatga  900
tggttgcta  cttagcaaa  tgaagtttc  ataaagagg  ctcaggcat  gctgaaaga  960
ttaaaagta  ctgtgaaca  ataatttgt  ctgtgcctt  tgcctggta  atagcaaat  1020
ctcaaaaag  attcaataa  tcaatcaat  aatataagt  tcatcttac  cgtaagata  1080
aggtcttat  tcctgatgg  gtgtccatt  tgcctggta  ataacagat  ataaatatc  1140
agtgtcaat  aatgtaaca  taaaaaaaa  aa  1172



<210> 4246
<211> 219
<212> PRT
<213> Homo sapiens
<308> AAF67658
<400> 4246

Met Trp Ile Gln Val Trp Met Thr Val Gly Thr Glu Glu Ala Pro Lys 
  1               5                  10                  15
Val Phe Lys Met Ala Ala Ser Met His Gly Gln Pro Ser Pro Ser Leu 
             20                  25                  30
Glu Asp Ala Lys Leu Arg Arg Pro Met Val Ile Glu Ile Ile Glu Lys 
         35                  40                  45
Asn Phe Asp Tyr Leu Arg Lys Glu Met Thr Gln Asn Ile Tyr Gln Met 
     50                  55                  60
Ala Thr Phe Gly Thr Thr Ala Gly Phe Ser Gly Ile Phe Ser Asn Phe 
 65                  70                  75                  80
Leu Phe Arg Arg Cys Phe Lys Val Lys His Asp Ala Leu Lys Thr Tyr 
                 85                  90                  95
Ala Ser Leu Ala Thr Leu Pro Phe Leu Ser Thr Val Val Thr Asp Lys 
             100                105                110
Leu Phe Val Ile Asp Ala Leu Tyr Ser Asp Asn Ile Ser Lys Glu Asn 
         115                120                125
Cys Val Phe Arg Ser Ser Leu Ile Gly Ile Val Cys Gly Val Phe Tyr 
     130                135                140
Pro Ser Ser Leu Ala Phe Thr Lys Asn Gly Arg Leu Ala Thr Lys Tyr 
 145                150                155                160
His Thr Val Pro Leu Pro Pro Lys Gly Arg Val Leu Ile His Trp Met 
                 165                170                175
Thr Leu Cys Gln Thr Gln Met Lys Leu Met Ala Ile Pro Leu Val Phe 
             180                185                190
Gln Ile Met Phe Gly Ile Leu Asn Gly Leu Tyr His Tyr Ala Val Phe 
         195                200                205
Glu Glu Thr Leu Glu Lys Thr Ile His Glu Glu 
     210                215



<210> 4247
<211> 250
<212> DNA
<213> Rattus norvegicus
<308> AA799448
<400> 4247

aagcatttt  aaactttat  tacaactgt  acagtgaca  aaagtagtt  ggaaaaaaa  60
aatgctagt  tctccctga  cctcgatac  gaacagaca  aagtcacag  aggttcatc  120
cacaacagg  atgtcactg  aatactagg  ttttttttt  caatacgat  agttagaaa  180
acacacaaa  tacttaaag  aagaagagg  ggaagagga  gaggagggg  ggaggagga  240
agggaagagg  250



<210> 4248
<211> 497
<212> DNA
<213> Homo sapiens
<308> BF109813
<400> 4248

tttttttaa  cattttcaa  ctttattta  aactgtcac  gtgacaaaa  gtagtttgg  60
aaaaaaaaa  gctagtttc  ccctgagcc  caaaaaaga  cagatagaa  ttacaaaaa  120
ctttttaaa  aattatata  acaatgtca  ccatagaag  tttaagtac  ttaaatcat  180
aactctgta  tttgtatag  agtcttata  aaatatagt  agctctcaa  tgtttaatg  240
cacttaagt  agttaaagt  cagattgta  agcatatta  gaaggtgcc  agaatacca  300
tgtctcctg  acttaacac  ttaatacaa  gtttgccaa  tgttttgaa  ttccaaatg  360
attcctgaa  aaaaaaaga  cctaaacac  atattatag  catatgtta  aaaagtcct  420
gaaatgcac  caatttcct  ccattttac  ttcctacat  gattgaagt  agcccctca  480
aagcttttc  gctgggc  497



<210> 4249
<211> 295
<212> PRT
<213> Homo sapiens
<308> P13726
<400> 4249

Met Glu Thr Pro Ala Trp Pro Arg Val Pro Arg Pro Glu Thr Ala Val 
  1               5                  10                  15
Ala Arg Thr Leu Leu Leu Gly Trp Val Phe Ala Gln Val Ala Gly Ala 
             20                  25                  30
Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
         35                  40                  45
Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
     50                  55                  60
Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
 65                  70                  75                  80
Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
                 85                  90                  95
Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
             100                105                110
Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
         115                120                125
Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
     130                135                140
Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
 145                150                155                160
Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
                 165                170                175
Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
             180                185                190
Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
         195                200                205
Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
     210                215                220
Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
 225                230                235                240
Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Ile Phe Tyr Ile Ile 
                 245                250                255
Gly Ala Val Val Phe Val Val Ile Ile Leu Val Ile Ile Leu Ala Ile 
             260                265                270
Ser Leu His Lys Cys Arg Lys Ala Gly Val Gly Gln Ser Trp Lys Glu 
         275                280                285
Asn Ser Pro Leu Asn Val Ser 
     290                295



<210> 4250
<211> 250
<212> DNA
<213> Rattus norvegicus
<308> AA799448
<400> 4250

aagcatttt  aaactttat  tacaactgt  acagtgaca  aaagtagtt  ggaaaaaaa  60
aatgctagt  tctccctga  cctcgatac  gaacagaca  aagtcacag  aggttcatc  120
cacaacagg  atgtcactg  aatactagg  ttttttttt  caatacgat  agttagaaa  180
acacacaaa  tacttaaag  aagaagagg  ggaagagga  gaggagggg  ggaggagga  240
agggaagagg  250



<210> 4251
<211> 497
<212> DNA
<213> Homo sapiens
<308> BF109813
<400> 4251

tttttttaa  cattttcaa  ctttattta  aactgtcac  gtgacaaaa  gtagtttgg  60
aaaaaaaaa  gctagtttc  ccctgagcc  caaaaaaga  cagatagaa  ttacaaaaa  120
ctttttaaa  aattatata  acaatgtca  ccatagaag  tttaagtac  ttaaatcat  180
aactctgta  tttgtatag  agtcttata  aaatatagt  agctctcaa  tgtttaatg  240
cacttaagt  agttaaagt  cagattgta  agcatatta  gaaggtgcc  agaatacca  300
tgtctcctg  acttaacac  ttaatacaa  gtttgccaa  tgttttgaa  ttccaaatg  360
attcctgaa  aaaaaaaga  cctaaacac  atattatag  catatgtta  aaaagtcct  420
gaaatgcac  caatttcct  ccattttac  ttcctacat  gattgaagt  agcccctca  480
aagcttttc  gctgggc  497



<210> 4252
<211> 295
<212> PRT
<213> Homo sapiens
<308> P13726
<400> 4252

Met Glu Thr Pro Ala Trp Pro Arg Val Pro Arg Pro Glu Thr Ala Val 
  1               5                  10                  15
Ala Arg Thr Leu Leu Leu Gly Trp Val Phe Ala Gln Val Ala Gly Ala 
             20                  25                  30
Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
         35                  40                  45
Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
     50                  55                  60
Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
 65                  70                  75                  80
Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
                 85                  90                  95
Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
             100                105                110
Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
         115                120                125
Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
     130                135                140
Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
 145                150                155                160
Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
                 165                170                175
Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
             180                185                190
Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
         195                200                205
Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
     210                215                220
Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
 225                230                235                240
Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Ile Phe Tyr Ile Ile 
                 245                250                255
Gly Ala Val Val Phe Val Val Ile Ile Leu Val Ile Ile Leu Ala Ile 
             260                265                270
Ser Leu His Lys Cys Arg Lys Ala Gly Val Gly Gln Ser Trp Lys Glu 
         275                280                285
Asn Ser Pro Leu Asn Val Ser 
     290                295



<210> 4253
<211> 553
<212> DNA
<213> Rattus norvegicus
<308> AA799449
<400> 4253

cacaacttt  atagaatat  ctaactatt  tgtacaaat  gaaaacacc  tattcagtt  60
caaatgtgt  attgggtaa  gctgagcac  ctctacatg  ctggtcact  tggacatgg  120
tgtcctggc  accagagac  caaccacac  ctcggaaac  ccccccccc  ccacactaa  180
caccaactg  tcaccaatc  caggtgtgg  cctggtgtg  acagtacaa  ctgaagctg  240
gctctacag  ccagagatc  tactgaggg  gaacttcct  gtagaactt  gcttctatg  300
gcgcacacc  cacctggag  tgcttcaga  cattaattc  tcttttgac  gctttaggt  360
aagtttcta  gtaactaga  ggagtgtga  agacgttgt  aagacgttc  tgcaaagct  420
ccagcactt  tgggttctg  atcacctgg  ctgtgagtt  ttctgtatt  ctggcattt  480
tagcagctt  cacagaatc  gctgggcct  catctgaaa  actgttttt  tgcatctga  540
cacctttgc  tcg  553



<210> 4254
<211> 375
<212> PRT
<213> Rattus norvegicus
<308> NP_032698
<400> 4254

Met Ala Glu Asn Ser Leu Ser Asp Gly Gly Pro Ala Asp Ser Val Glu 
  1               5                  10                  15
Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
             20                  25                  30
Gln Asn Pro Gln Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
         35                  40                  45
Ser His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
     50                  55                  60
Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
 65                  70                  75                  80
Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                 85                  90                  95
Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
             100                105                110
Asp Val Glu Pro Thr Asp Ala Glu Ser Ala Trp His Ser Glu Asn Glu 
         115                120                125
Glu Glu Asp Lys Leu Ala Gly Asp Met Lys Asn Lys Val Val Ile Ala 
     130                135                140
Glu Lys Glu Ala Ala Thr Val Glu Glu Leu Asn Pro Lys Gly Ile Pro 
 145                150                155                160
Glu Phe Trp Phe Thr Ile Phe Arg Asn Val Asp Met Leu Ser Glu Leu 
                 165                170                175
Val Gln Glu Tyr Asp Glu Pro Ile Leu Lys His Leu Gln Asp Ile Lys 
             180                185                190
Val Lys Phe Ser Asp Pro Gly Gln Pro Met Ser Phe Val Leu Glu Phe 
         195                200                205
His Phe Glu Pro Asn Asp Tyr Phe Thr Asn Pro Val Leu Thr Lys Thr 
     210                215                220
Tyr Lys Met Lys Ser Glu Pro Asp Lys Ala Asp Pro Phe Ser Phe Glu 
 225                230                235                240
Gly Pro Glu Ile Val Asp Cys Asp Gly Cys Thr Ile Asp Trp Lys Lys 
                 245                250                255
Gly Lys Asn Val Thr Val Lys Thr Ile Lys Lys Lys Gln Lys His Lys 
             260                265                270
Gly Arg Gly Thr Val Arg Thr Ile Thr Lys Gln Val Pro Asn Glu Ser 
         275                280                285
Phe Phe Asn Phe Phe Ser Pro Leu Lys Ala Ser Gly Asp Gly Glu Ser 
     290                295                300
Leu Asp Glu Asp Ser Glu Phe Thr Leu Ala Ser Asp Phe Glu Ile Gly 
 305                310                315                320
His Phe Phe Arg Glu Arg Ile Val Pro Arg Ala Val Leu Tyr Phe Thr 
                 325                330                335
Gly Glu Ala Ile Glu Asp Asp Asp Asn Phe Glu Glu Gly Glu Glu Gly 
             340                345                350
Glu Glu Glu Glu Leu Glu Gly Asp Glu Glu Gly Glu Asp Glu Asp Asp 
         355                360                365
Ala Asp Val Asn Pro Lys Val 
     370                375



<210> 4255
<211> 2534
<212> DNA
<213> Homo sapiens
<308> U77456
<400> 4255

ggcacgagc  tgctcgcgg  gagaggagc  aggagcctc  gccaatggg  gccggcgtt  60
ttggaggcc  cggcggcgc  gccccaaag  gagcgaagc  agggtcgcc  ccactgccg  120
aggaggcgt  aggggataa  aacattcag  tggcagatc  cagtttttc  gatggggtt  180
cttcagatt  cgtggaagc  gctaaaaat  caagtaaca  agaaaagct  acagatcag  240
tgatgcaga  tcctcgagt  ctggcagct  tacaggagc  acttgacaa  gtccctcac  300
ccccttcca  ctacatcga  actttacct  aagcagtaa  aagaagaat  aatgcattg  360
aacaacttc  ggtgagatg  gctcacata  aagccaagt  ctatgaaga  gtacatgac  420
tggaaagaa  gtatgcagc  ctataccag  ctctctttg  caagagaag  gaatttatc  480
ccggcgatg  tgaaccaac  gatgcggaa  cggaatggc  cagtgaaaa  gaagaggaa  540
agaaattgg  tggagacat  aaaagtaaa  tagtcgtca  agaaaaagc  gcggcaacg  600
ctgaagagc  agatcccaa  ggaattcca  agttctggt  taccatctt  agaaatgtg  660
acatgctga  tgaattagt  caggaatat  atgaaccaa  cttgaaaca  ctgcaggat  720
ttaaagtga  attttctga  cctggacag  ctatgtctt  tgtgttaga  ttccacttt  780
aacccaacg  ctactttac  aactcagtc  tgacaaaaa  ctacaagat  aaatcagaa  840
cagataagg  tgatccctt  tcctttgaa  gtcctgaga  tgtggactg  gacgggtgt  900
ctattgact  gaagaaagg  aagaatgtt  ctgtcaaaa  catcaagaa  aagcagaag  960
ataagggtc  aggcactgt  agaacaatt  cgaaacaag  acccaatga  tcctttttc  1020
acttcttca  tccattgaa  gcatccggg  atggagaat  actggatga  gattctgaa  1080
tcacattag  ctctgattt  gaaattgga  actttttcc  tgagcggat  gtcccgcgg  1140
ctgtgctgt  cttcactgg  gaggccata  aagatgatg  caattttga  gaaggtgaa  1200
aaggagaag  ggaggaatt  gaaggtgac  aggagggag  agacgagga  gatgcggaa  1260
ttaacccca  ggtgtaatt  ttgtctgtt  atcattcat  cgtttctag  aggaaccca  1320
ccagccggc  gaatgcaag  agcagtagg  agcggaggc  ggtgcctgg  agaccggct  1380
tcgggactc  aggcctgtg  gcggggcct  ggtccttgc  gcagcacaa  cccgtggac  1440
gagcttact  catctaact  gttttcaag  gcatgattt  cactttcac  tttcctttt  1500
ccttattat  ttgattaac  tgtacagtg  caactgaaa  gcatttcag  aataggagg  1560
ttcgtccag  accctctgc  gccttggtg  ctgtagctc  ggacttccc  gggcctttc  1620
ctgtgggag  gccctgtag  cacatcagg  tggggtggg  gtcacttgg  aaaaagggc  1680
gaggtctgg  gatgtggtt  ccaggatct  ggaacctct  ccacccctc  tgcagttgg  1740
ctgaattct  ccctttcat  cgaagaaac  cacttgctg  ttccagccg  tgaatctgc  1800
gagtgtgca  cctgcatca  ctgctgtat  ccgatcatc  cagaaaggg  tgtgtagag  1860
agggccctg  tctccttag  atgttgctt  ttgattttt  ttttttttt  ggggtgggt  1920
agggttgtg  cacaccagc  caggtgaga  ctgctgcgg  tcacctcat  tttatttat  1980
ccttcttgc  tgtgaggac  gcggctttt  gctgtggct  gtccttaac  tttctgaac  2040
accttggtg  cctgagcag  aagatgtgc  acttcctag  aggcgcaag  cctgtgcgg  2100
agaaacgcc  ctccctgcc  ccagggctg  agatgcgag  ccgtcctca  gacgcaggc  2160
ccaccctgc  gccggagcc  ggcttcggc  tcttctcca  tgagggact  ggctgggaa  2220
tcctgcgtt  cagtggagc  tatgagcgt  aagtcctgc  ttctcagta  ccccattgc  2280
gggccccac  attcatcct  tctgaaggt  ctgggtttg  tgtgaccgc  tggcggctg  2340
tgggtgggg  tttcaagtg  gtgacggcg  tctccggca  ccggggatg  ccgtgtccg  2400
actgaccag  cctgtggag  gtgctcggc  taaccttag  acacaattg  aactgaaaa  2460
agtgttttc  atttgtaca  aatagttag  atattctaa  aaagtggtg  aacattgaa  2520
aaaaaanaa  aaaa  2534



<210> 4256
<211> 375
<212> PRT
<213> Homo sapiens
<308> Q99733
<400> 4256

Met Ala Asp His Ser Phe Ser Asp Gly Val Pro Ser Asp Ser Val Glu 
  1               5                  10                  15
Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
             20                  25                  30
Gln Asn Pro Arg Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
         35                  40                  45
Pro His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
     50                  55                  60
Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
 65                  70                  75                  80
Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                 85                  90                  95
Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
             100                105                110
Asp Val Glu Pro Thr Asp Ala Glu Ser Glu Trp His Ser Glu Asn Glu 
         115                120                125
Glu Glu Glu Lys Leu Ala Gly Asp Met Lys Ser Lys Val Val Val Thr 
     130                135                140
Glu Lys Ala Ala Ala Thr Ala Glu Glu Pro Asp Pro Lys Gly Ile Pro 
 145                150                155                160
Glu Phe Trp Phe Thr Ile Phe Arg Asn Val Asp Met Leu Ser Glu Leu 
                 165                170                175
Val Gln Glu Tyr Asp Glu Pro Ile Leu Lys His Leu Gln Asp Ile Lys 
             180                185                190
Val Lys Phe Ser Asp Pro Gly Gln Pro Met Ser Phe Val Leu Glu Phe 
         195                200                205
His Phe Glu Pro Asn Asp Tyr Phe Thr Asn Ser Val Leu Thr Lys Thr 
     210                215                220
Tyr Lys Met Lys Ser Glu Pro Asp Lys Ala Asp Pro Phe Ser Phe Glu 
 225                230                235                240
Gly Pro Glu Ile Val Asp Cys Asp Gly Cys Thr Ile Asp Trp Lys Lys 
                 245                250                255
Gly Lys Asn Val Thr Val Lys Thr Ile Lys Lys Lys Gln Lys His Lys 
             260                265                270
Gly Arg Gly Thr Val Arg Thr Ile Thr Lys Gln Val Pro Asn Glu Ser 
         275                280                285
Phe Phe Asn Phe Phe Asn Pro Leu Lys Ala Ser Gly Asp Gly Glu Ser 
     290                295                300
Leu Asp Glu Asp Ser Glu Phe Thr Leu Ala Ser Asp Phe Glu Ile Gly 
 305                310                315                320
His Phe Phe Arg Glu Arg Ile Val Pro Arg Ala Val Leu Tyr Phe Thr 
                 325                330                335
Gly Glu Ala Ile Glu Asp Asp Asp Asn Phe Glu Glu Gly Glu Glu Gly 
             340                345                350
Glu Glu Glu Glu Leu Glu Gly Asp Glu Glu Gly Glu Asp Glu Asp Asp 
         355                360                365
Ala Glu Ile Asn Pro Lys Val 
     370                375



<210> 4257
<211> 553
<212> DNA
<213> Rattus norvegicus
<308> AA799449
<400> 4257

cacaacttt  atagaatat  ctaactatt  tgtacaaat  gaaaacacc  tattcagtt  60
caaatgtgt  attgggtaa  gctgagcac  ctctacatg  ctggtcact  tggacatgg  120
tgtcctggc  accagagac  caaccacac  ctcggaaac  ccccccccc  ccacactaa  180
caccaactg  tcaccaatc  caggtgtgg  cctggtgtg  acagtacaa  ctgaagctg  240
gctctacag  ccagagatc  tactgaggg  gaacttcct  gtagaactt  gcttctatg  300
gcgcacacc  cacctggag  tgcttcaga  cattaattc  tcttttgac  gctttaggt  360
aagtttcta  gtaactaga  ggagtgtga  agacgttgt  aagacgttc  tgcaaagct  420
ccagcactt  tgggttctg  atcacctgg  ctgtgagtt  ttctgtatt  ctggcattt  480
tagcagctt  cacagaatc  gctgggcct  catctgaaa  actgttttt  tgcatctga  540
cacctttgc  tcg  553



<210> 4258
<211> 375
<212> PRT
<213> Rattus norvegicus
<308> NP_032698
<400> 4258

Met Ala Glu Asn Ser Leu Ser Asp Gly Gly Pro Ala Asp Ser Val Glu 
  1               5                  10                  15
Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
             20                  25                  30
Gln Asn Pro Gln Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
         35                  40                  45
Ser His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
     50                  55                  60
Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
 65                  70                  75                  80
Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                 85                  90                  95
Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
             100                105                110
Asp Val Glu Pro Thr Asp Ala Glu Ser Ala Trp His Ser Glu Asn Glu 
         115                120                125
Glu Glu Asp Lys Leu Ala Gly Asp Met Lys Asn Lys Val Val Ile Ala 
     130                135                140
Glu Lys Glu Ala Ala Thr Val Glu Glu Leu Asn Pro Lys Gly Ile Pro 
 145                150                155                160
Glu Phe Trp Phe Thr Ile Phe Arg Asn Val Asp Met Leu Ser Glu Leu 
                 165                170                175
Val Gln Glu Tyr Asp Glu Pro Ile Leu Lys His Leu Gln Asp Ile Lys 
             180                185                190
Val Lys Phe Ser Asp Pro Gly Gln Pro Met Ser Phe Val Leu Glu Phe 
         195                200                205
His Phe Glu Pro Asn Asp Tyr Phe Thr Asn Pro Val Leu Thr Lys Thr 
     210                215                220
Tyr Lys Met Lys Ser Glu Pro Asp Lys Ala Asp Pro Phe Ser Phe Glu 
 225                230                235                240
Gly Pro Glu Ile Val Asp Cys Asp Gly Cys Thr Ile Asp Trp Lys Lys 
                 245                250                255
Gly Lys Asn Val Thr Val Lys Thr Ile Lys Lys Lys Gln Lys His Lys 
             260                265                270
Gly Arg Gly Thr Val Arg Thr Ile Thr Lys Gln Val Pro Asn Glu Ser 
         275                280                285
Phe Phe Asn Phe Phe Ser Pro Leu Lys Ala Ser Gly Asp Gly Glu Ser 
     290                295                300
Leu Asp Glu Asp Ser Glu Phe Thr Leu Ala Ser Asp Phe Glu Ile Gly 
 305                310                315                320
His Phe Phe Arg Glu Arg Ile Val Pro Arg Ala Val Leu Tyr Phe Thr 
                 325                330                335
Gly Glu Ala Ile Glu Asp Asp Asp Asn Phe Glu Glu Gly Glu Glu Gly 
             340                345                350
Glu Glu Glu Glu Leu Glu Gly Asp Glu Glu Gly Glu Asp Glu Asp Asp 
         355                360                365
Ala Asp Val Asn Pro Lys Val 
     370                375



<210> 4259
<211> 2534
<212> DNA
<213> Homo sapiens
<308> U77456
<400> 4259

ggcacgagc  tgctcgcgg  gagaggagc  aggagcctc  gccaatggg  gccggcgtt  60
ttggaggcc  cggcggcgc  gccccaaag  gagcgaagc  agggtcgcc  ccactgccg  120
aggaggcgt  aggggataa  aacattcag  tggcagatc  cagtttttc  gatggggtt  180
cttcagatt  cgtggaagc  gctaaaaat  caagtaaca  agaaaagct  acagatcag  240
tgatgcaga  tcctcgagt  ctggcagct  tacaggagc  acttgacaa  gtccctcac  300
ccccttcca  ctacatcga  actttacct  aagcagtaa  aagaagaat  aatgcattg  360
aacaacttc  ggtgagatg  gctcacata  aagccaagt  ctatgaaga  gtacatgac  420
tggaaagaa  gtatgcagc  ctataccag  ctctctttg  caagagaag  gaatttatc  480
ccggcgatg  tgaaccaac  gatgcggaa  cggaatggc  cagtgaaaa  gaagaggaa  540
agaaattgg  tggagacat  aaaagtaaa  tagtcgtca  agaaaaagc  gcggcaacg  600
ctgaagagc  agatcccaa  ggaattcca  agttctggt  taccatctt  agaaatgtg  660
acatgctga  tgaattagt  caggaatat  atgaaccaa  cttgaaaca  ctgcaggat  720
ttaaagtga  attttctga  cctggacag  ctatgtctt  tgtgttaga  ttccacttt  780
aacccaacg  ctactttac  aactcagtc  tgacaaaaa  ctacaagat  aaatcagaa  840
cagataagg  tgatccctt  tcctttgaa  gtcctgaga  tgtggactg  gacgggtgt  900
ctattgact  gaagaaagg  aagaatgtt  ctgtcaaaa  catcaagaa  aagcagaag  960
ataagggtc  aggcactgt  agaacaatt  cgaaacaag  acccaatga  tcctttttc  1020
acttcttca  tccattgaa  gcatccggg  atggagaat  actggatga  gattctgaa  1080
tcacattag  ctctgattt  gaaattgga  actttttcc  tgagcggat  gtcccgcgg  1140
ctgtgctgt  cttcactgg  gaggccata  aagatgatg  caattttga  gaaggtgaa  1200
aaggagaag  ggaggaatt  gaaggtgac  aggagggag  agacgagga  gatgcggaa  1260
ttaacccca  ggtgtaatt  ttgtctgtt  atcattcat  cgtttctag  aggaaccca  1320
ccagccggc  gaatgcaag  agcagtagg  agcggaggc  ggtgcctgg  agaccggct  1380
tcgggactc  aggcctgtg  gcggggcct  ggtccttgc  gcagcacaa  cccgtggac  1440
gagcttact  catctaact  gttttcaag  gcatgattt  cactttcac  tttcctttt  1500
ccttattat  ttgattaac  tgtacagtg  caactgaaa  gcatttcag  aataggagg  1560
ttcgtccag  accctctgc  gccttggtg  ctgtagctc  ggacttccc  gggcctttc  1620
ctgtgggag  gccctgtag  cacatcagg  tggggtggg  gtcacttgg  aaaaagggc  1680
gaggtctgg  gatgtggtt  ccaggatct  ggaacctct  ccacccctc  tgcagttgg  1740
ctgaattct  ccctttcat  cgaagaaac  cacttgctg  ttccagccg  tgaatctgc  1800
gagtgtgca  cctgcatca  ctgctgtat  ccgatcatc  cagaaaggg  tgtgtagag  1860
agggccctg  tctccttag  atgttgctt  ttgattttt  ttttttttt  ggggtgggt  1920
agggttgtg  cacaccagc  caggtgaga  ctgctgcgg  tcacctcat  tttatttat  1980
ccttcttgc  tgtgaggac  gcggctttt  gctgtggct  gtccttaac  tttctgaac  2040
accttggtg  cctgagcag  aagatgtgc  acttcctag  aggcgcaag  cctgtgcgg  2100
agaaacgcc  ctccctgcc  ccagggctg  agatgcgag  ccgtcctca  gacgcaggc  2160
ccaccctgc  gccggagcc  ggcttcggc  tcttctcca  tgagggact  ggctgggaa  2220
tcctgcgtt  cagtggagc  tatgagcgt  aagtcctgc  ttctcagta  ccccattgc  2280
gggccccac  attcatcct  tctgaaggt  ctgggtttg  tgtgaccgc  tggcggctg  2340
tgggtgggg  tttcaagtg  gtgacggcg  tctccggca  ccggggatg  ccgtgtccg  2400
actgaccag  cctgtggag  gtgctcggc  taaccttag  acacaattg  aactgaaaa  2460
agtgttttc  atttgtaca  aatagttag  atattctaa  aaagtggtg  aacattgaa  2520
aaaaaanaa  aaaa  2534



<210> 4260
<211> 375
<212> PRT
<213> Homo sapiens
<308> Q99733
<400> 4260

Met Ala Asp His Ser Phe Ser Asp Gly Val Pro Ser Asp Ser Val Glu 
  1               5                  10                  15
Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
             20                  25                  30
Gln Asn Pro Arg Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
         35                  40                  45
Pro His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
     50                  55                  60
Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
 65                  70                  75                  80
Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                 85                  90                  95
Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
             100                105                110
Asp Val Glu Pro Thr Asp Ala Glu Ser Glu Trp His Ser Glu Asn Glu 
         115                120                125
Glu Glu Glu Lys Leu Ala Gly Asp Met Lys Ser Lys Val Val Val Thr 
     130                135                140
Glu Lys Ala Ala Ala Thr Ala Glu Glu Pro Asp Pro Lys Gly Ile Pro 
 145                150                155                160
Glu Phe Trp Phe Thr Ile Phe Arg Asn Val Asp Met Leu Ser Glu Leu 
                 165                170                175
Val Gln Glu Tyr Asp Glu Pro Ile Leu Lys His Leu Gln Asp Ile Lys 
             180                185                190
Val Lys Phe Ser Asp Pro Gly Gln Pro Met Ser Phe Val Leu Glu Phe 
         195                200                205
His Phe Glu Pro Asn Asp Tyr Phe Thr Asn Ser Val Leu Thr Lys Thr 
     210                215                220
Tyr Lys Met Lys Ser Glu Pro Asp Lys Ala Asp Pro Phe Ser Phe Glu 
 225                230                235                240
Gly Pro Glu Ile Val Asp Cys Asp Gly Cys Thr Ile Asp Trp Lys Lys 
                 245                250                255
Gly Lys Asn Val Thr Val Lys Thr Ile Lys Lys Lys Gln Lys His Lys 
             260                265                270
Gly Arg Gly Thr Val Arg Thr Ile Thr Lys Gln Val Pro Asn Glu Ser 
         275                280                285
Phe Phe Asn Phe Phe Asn Pro Leu Lys Ala Ser Gly Asp Gly Glu Ser 
     290                295                300
Leu Asp Glu Asp Ser Glu Phe Thr Leu Ala Ser Asp Phe Glu Ile Gly 
 305                310                315                320
His Phe Phe Arg Glu Arg Ile Val Pro Arg Ala Val Leu Tyr Phe Thr 
                 325                330                335
Gly Glu Ala Ile Glu Asp Asp Asp Asn Phe Glu Glu Gly Glu Glu Gly 
             340                345                350
Glu Glu Glu Glu Leu Glu Gly Asp Glu Glu Gly Glu Asp Glu Asp Asp 
         355                360                365
Ala Glu Ile Asn Pro Lys Val 
     370                375



<210> 4261
<211> 553
<212> DNA
<213> Rattus norvegicus
<308> AA799449
<400> 4261

cacaacttt  atagaatat  ctaactatt  tgtacaaat  gaaaacacc  tattcagtt  60
caaatgtgt  attgggtaa  gctgagcac  ctctacatg  ctggtcact  tggacatgg  120
tgtcctggc  accagagac  caaccacac  ctcggaaac  ccccccccc  ccacactaa  180
caccaactg  tcaccaatc  caggtgtgg  cctggtgtg  acagtacaa  ctgaagctg  240
gctctacag  ccagagatc  tactgaggg  gaacttcct  gtagaactt  gcttctatg  300
gcgcacacc  cacctggag  tgcttcaga  cattaattc  tcttttgac  gctttaggt  360
aagtttcta  gtaactaga  ggagtgtga  agacgttgt  aagacgttc  tgcaaagct  420
ccagcactt  tgggttctg  atcacctgg  ctgtgagtt  ttctgtatt  ctggcattt  480
tagcagctt  cacagaatc  gctgggcct  catctgaaa  actgttttt  tgcatctga  540
cacctttgc  tcg  553



<210> 4262
<211> 375
<212> PRT
<213> Rattus norvegicus
<308> NP_032698
<400> 4262

Met Ala Glu Asn Ser Leu Ser Asp Gly Gly Pro Ala Asp Ser Val Glu 
  1               5                  10                  15
Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
             20                  25                  30
Gln Asn Pro Gln Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
         35                  40                  45
Ser His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
     50                  55                  60
Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
 65                  70                  75                  80
Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                 85                  90                  95
Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
             100                105                110
Asp Val Glu Pro Thr Asp Ala Glu Ser Ala Trp His Ser Glu Asn Glu 
         115                120                125
Glu Glu Asp Lys Leu Ala Gly Asp Met Lys Asn Lys Val Val Ile Ala 
     130                135                140
Glu Lys Glu Ala Ala Thr Val Glu Glu Leu Asn Pro Lys Gly Ile Pro 
 145                150                155                160
Glu Phe Trp Phe Thr Ile Phe Arg Asn Val Asp Met Leu Ser Glu Leu 
                 165                170                175
Val Gln Glu Tyr Asp Glu Pro Ile Leu Lys His Leu Gln Asp Ile Lys 
             180                185                190
Val Lys Phe Ser Asp Pro Gly Gln Pro Met Ser Phe Val Leu Glu Phe 
         195                200                205
His Phe Glu Pro Asn Asp Tyr Phe Thr Asn Pro Val Leu Thr Lys Thr 
     210                215                220
Tyr Lys Met Lys Ser Glu Pro Asp Lys Ala Asp Pro Phe Ser Phe Glu 
 225                230                235                240
Gly Pro Glu Ile Val Asp Cys Asp Gly Cys Thr Ile Asp Trp Lys Lys 
                 245                250                255
Gly Lys Asn Val Thr Val Lys Thr Ile Lys Lys Lys Gln Lys His Lys 
             260                265                270
Gly Arg Gly Thr Val Arg Thr Ile Thr Lys Gln Val Pro Asn Glu Ser 
         275                280                285
Phe Phe Asn Phe Phe Ser Pro Leu Lys Ala Ser Gly Asp Gly Glu Ser 
     290                295                300
Leu Asp Glu Asp Ser Glu Phe Thr Leu Ala Ser Asp Phe Glu Ile Gly 
 305                310                315                320
His Phe Phe Arg Glu Arg Ile Val Pro Arg Ala Val Leu Tyr Phe Thr 
                 325                330                335
Gly Glu Ala Ile Glu Asp Asp Asp Asn Phe Glu Glu Gly Glu Glu Gly 
             340                345                350
Glu Glu Glu Glu Leu Glu Gly Asp Glu Glu Gly Glu Asp Glu Asp Asp 
         355                360                365
Ala Asp Val Asn Pro Lys Val 
     370                375



<210> 4263
<211> 2534
<212> DNA
<213> Homo sapiens
<308> U77456
<400> 4263

ggcacgagc  tgctcgcgg  gagaggagc  aggagcctc  gccaatggg  gccggcgtt  60
ttggaggcc  cggcggcgc  gccccaaag  gagcgaagc  agggtcgcc  ccactgccg  120
aggaggcgt  aggggataa  aacattcag  tggcagatc  cagtttttc  gatggggtt  180
cttcagatt  cgtggaagc  gctaaaaat  caagtaaca  agaaaagct  acagatcag  240
tgatgcaga  tcctcgagt  ctggcagct  tacaggagc  acttgacaa  gtccctcac  300
ccccttcca  ctacatcga  actttacct  aagcagtaa  aagaagaat  aatgcattg  360
aacaacttc  ggtgagatg  gctcacata  aagccaagt  ctatgaaga  gtacatgac  420
tggaaagaa  gtatgcagc  ctataccag  ctctctttg  caagagaag  gaatttatc  480
ccggcgatg  tgaaccaac  gatgcggaa  cggaatggc  cagtgaaaa  gaagaggaa  540
agaaattgg  tggagacat  aaaagtaaa  tagtcgtca  agaaaaagc  gcggcaacg  600
ctgaagagc  agatcccaa  ggaattcca  agttctggt  taccatctt  agaaatgtg  660
acatgctga  tgaattagt  caggaatat  atgaaccaa  cttgaaaca  ctgcaggat  720
ttaaagtga  attttctga  cctggacag  ctatgtctt  tgtgttaga  ttccacttt  780
aacccaacg  ctactttac  aactcagtc  tgacaaaaa  ctacaagat  aaatcagaa  840
cagataagg  tgatccctt  tcctttgaa  gtcctgaga  tgtggactg  gacgggtgt  900
ctattgact  gaagaaagg  aagaatgtt  ctgtcaaaa  catcaagaa  aagcagaag  960
ataagggtc  aggcactgt  agaacaatt  cgaaacaag  acccaatga  tcctttttc  1020
acttcttca  tccattgaa  gcatccggg  atggagaat  actggatga  gattctgaa  1080
tcacattag  ctctgattt  gaaattgga  actttttcc  tgagcggat  gtcccgcgg  1140
ctgtgctgt  cttcactgg  gaggccata  aagatgatg  caattttga  gaaggtgaa  1200
aaggagaag  ggaggaatt  gaaggtgac  aggagggag  agacgagga  gatgcggaa  1260
ttaacccca  ggtgtaatt  ttgtctgtt  atcattcat  cgtttctag  aggaaccca  1320
ccagccggc  gaatgcaag  agcagtagg  agcggaggc  ggtgcctgg  agaccggct  1380
tcgggactc  aggcctgtg  gcggggcct  ggtccttgc  gcagcacaa  cccgtggac  1440
gagcttact  catctaact  gttttcaag  gcatgattt  cactttcac  tttcctttt  1500
ccttattat  ttgattaac  tgtacagtg  caactgaaa  gcatttcag  aataggagg  1560
ttcgtccag  accctctgc  gccttggtg  ctgtagctc  ggacttccc  gggcctttc  1620
ctgtgggag  gccctgtag  cacatcagg  tggggtggg  gtcacttgg  aaaaagggc  1680
gaggtctgg  gatgtggtt  ccaggatct  ggaacctct  ccacccctc  tgcagttgg  1740
ctgaattct  ccctttcat  cgaagaaac  cacttgctg  ttccagccg  tgaatctgc  1800
gagtgtgca  cctgcatca  ctgctgtat  ccgatcatc  cagaaaggg  tgtgtagag  1860
agggccctg  tctccttag  atgttgctt  ttgattttt  ttttttttt  ggggtgggt  1920
agggttgtg  cacaccagc  caggtgaga  ctgctgcgg  tcacctcat  tttatttat  1980
ccttcttgc  tgtgaggac  gcggctttt  gctgtggct  gtccttaac  tttctgaac  2040
accttggtg  cctgagcag  aagatgtgc  acttcctag  aggcgcaag  cctgtgcgg  2100
agaaacgcc  ctccctgcc  ccagggctg  agatgcgag  ccgtcctca  gacgcaggc  2160
ccaccctgc  gccggagcc  ggcttcggc  tcttctcca  tgagggact  ggctgggaa  2220
tcctgcgtt  cagtggagc  tatgagcgt  aagtcctgc  ttctcagta  ccccattgc  2280
gggccccac  attcatcct  tctgaaggt  ctgggtttg  tgtgaccgc  tggcggctg  2340
tgggtgggg  tttcaagtg  gtgacggcg  tctccggca  ccggggatg  ccgtgtccg  2400
actgaccag  cctgtggag  gtgctcggc  taaccttag  acacaattg  aactgaaaa  2460
agtgttttc  atttgtaca  aatagttag  atattctaa  aaagtggtg  aacattgaa  2520
aaaaaanaa  aaaa  2534



<210> 4264
<211> 375
<212> PRT
<213> Homo sapiens
<308> Q99733
<400> 4264

Met Ala Asp His Ser Phe Ser Asp Gly Val Pro Ser Asp Ser Val Glu 
  1               5                  10                  15
Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
             20                  25                  30
Gln Asn Pro Arg Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
         35                  40                  45
Pro His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
     50                  55                  60
Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
 65                  70                  75                  80
Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                 85                  90                  95
Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
             100                105                110
Asp Val Glu Pro Thr Asp Ala Glu Ser Glu Trp His Ser Glu Asn Glu 
         115                120                125
Glu Glu Glu Lys Leu Ala Gly Asp Met Lys Ser Lys Val Val Val Thr 
     130                135                140
Glu Lys Ala Ala Ala Thr Ala Glu Glu Pro Asp Pro Lys Gly Ile Pro 
 145                150                155                160
Glu Phe Trp Phe Thr Ile Phe Arg Asn Val Asp Met Leu Ser Glu Leu 
                 165                170                175
Val Gln Glu Tyr Asp Glu Pro Ile Leu Lys His Leu Gln Asp Ile Lys 
             180                185                190
Val Lys Phe Ser Asp Pro Gly Gln Pro Met Ser Phe Val Leu Glu Phe 
         195                200                205
His Phe Glu Pro Asn Asp Tyr Phe Thr Asn Ser Val Leu Thr Lys Thr 
     210                215                220
Tyr Lys Met Lys Ser Glu Pro Asp Lys Ala Asp Pro Phe Ser Phe Glu 
 225                230                235                240
Gly Pro Glu Ile Val Asp Cys Asp Gly Cys Thr Ile Asp Trp Lys Lys 
                 245                250                255
Gly Lys Asn Val Thr Val Lys Thr Ile Lys Lys Lys Gln Lys His Lys 
             260                265                270
Gly Arg Gly Thr Val Arg Thr Ile Thr Lys Gln Val Pro Asn Glu Ser 
         275                280                285
Phe Phe Asn Phe Phe Asn Pro Leu Lys Ala Ser Gly Asp Gly Glu Ser 
     290                295                300
Leu Asp Glu Asp Ser Glu Phe Thr Leu Ala Ser Asp Phe Glu Ile Gly 
 305                310                315                320
His Phe Phe Arg Glu Arg Ile Val Pro Arg Ala Val Leu Tyr Phe Thr 
                 325                330                335
Gly Glu Ala Ile Glu Asp Asp Asp Asn Phe Glu Glu Gly Glu Glu Gly 
             340                345                350
Glu Glu Glu Glu Leu Glu Gly Asp Glu Glu Gly Glu Asp Glu Asp Asp 
         355                360                365
Ala Glu Ile Asn Pro Lys Val 
     370                375



<210> 4265
<211> 644
<212> DNA
<213> Rattus norvegicus
<308> AA799465
<400> 4265

caataacca  gatattgga  tttattaaa  ttgaagatt  tattagtca  cttacctgt  60
gctttgaca  aataccgga  acaaagaac  gtaggaaag  atgatttgt  ctggctccc  120
gtccattgt  ccagtagga  cagctcata  ctgtaacag  aggaacatg  gagttcgct  180
acatctctg  cttgggaga  ggtgtcagg  gaagctcaa  gtcatcctc  gggatgcag  240
gaactcaag  ctagcctgg  gtacatgag  ccagcatcc  atcccgaac  gcatttttc  300
ttcttgccg  atcatcctt  ccagaaccc  ggggagaaa  gccaagact  tcctgttca  360
gtcatcttg  tttgcctgg  ttttgtggg  gaggagcct  cagtcttcc  cgagaacac  420
taggtacaa  acttgtatg  atcttcagt  tttcctcaa  tctggatga  agatccctt  480
tattgctgc  catcgtctt  aatttcgtc  tctgggtga  caccactgg  gacgggcgt  540
tcccacgca  ccacccggg  acgcactta  ccaactgag  agcccacca  acgccagtt  600
cgggccact  ttggctccg  cgccgttgg  ggctgcgcc  ctcc  644



<210> 4266
<211> 481
<212> DNA
<213> Rattus norvegicus
<308> AA799467
<400> 4266

aaaatcatg  ttgtattta  ataagtcga  tgcagagca  tttgccaca  ttcatacac  60
ggtgtcaga  tgaggtata  aaaacatac  gagaaatac  ttcatagga  agtaggaag  120
tgttcagtt  tctcccaca  tcagcacca  cgtgggaac  ctgaggtcc  ggccccctc  180
acaaatggc  ctagagagc  gcctggtga  gcctgctct  agtgtcagg  gtagagggg  240
tcctggtgg  gacactgcc  aggccagga  actgggcgc  ctcggcagg  cactcagaa  300
ctgcttttc  ctctctgga  aaccctttg  gtccttccc  gtgtttcag  gattgtttt  360
taccagtta  acccttaac  ttgtggaag  agctgtccc  agccttagg  ctgcctgca  420
gccaggttg  actacaaag  cagccccac  caccgtgcc  ttgttacca  cctctggct  480
a  481



<210> 4267
<211> 577
<212> DNA
<213> Rattus norvegicus
<308> AA799473
<400> 4267

ggggtgtga  aggtggagc  ggaacctgg  ctgcataca  ttgccggct  cgctggagg  60
acaggcccc  ctggttggt  ccaagggga  actgtactt  gattgtcaa  caccagatc  120
catgggctg  ggacccggg  tccctattc  tgatgagta  gacacagga  gtttgtagt  180
tacacaatg  attcaacaa  aaaaacagg  tgtggggga  gatgtgcga  gtgattttt  240
accactggg  gagaggagc  aggggtaag  gacaagggg  tgcacagac  gtaccgtgc  300
aggggaccc  acgggaagg  catattgca  tgaggttgg  gtggggctg  acaggggac  360
tgctgggat  gcttgagga  aacagaggc  ggccgggga  ggcacctct  cagccttgg  420
ggtggggtc  cgacgatat  tacagattc  cttttgaca  agtccatgt  gcccagctg  480
ccttcagct  gatacagct  aggatggct  gcactcctg  tccttctgc  tgttttcca  540
gcgatggat  gcagctgtg  gcctcccaa  ccgggtc  577



<210> 4268
<211> 687
<212> DNA
<213> Rattus norvegicus
<308> AA799474
<400> 4268

gagaaactt  atttattcc  acaatgaag  ctaaaggaa  atcagaagc  agagtctgg  60
ctcctggcc  tggtatctg  tgaaaaggg  ccaggcctg  aaggcctcg  actgttcct  120
gtctgctga  agcttgttc  ggcaagatg  caagcagat  ctgaacagg  tcacttggg  180
ggccgataa  ccagctttc  actcttcag  actgaccac  tatgccgct  catggcata  240
gtcaggggc  gcagcaagc  catcatcaa  aacatcttg  gtcccatgc  ttttcgatg  300
tcatgctct  gctctgatg  ccagcgaag  aaggtggca  catccttgg  tacttgtga  360
atggtagct  gggtaccat  gtcatactc  aagacttct  tgtagatgg  aggagccat  420
ccaatggcc  ggccaggaa  gtaagggtt  aaatagagg  ttctcgcaa  gacacccca  480
tgggaggtt  acagtannc  gtgagcaaa  gaaacacat  ntcctcaca  cgtgccttg  540
tcgaacgat  tactgagtc  ggggtaaag  tccatgnnt  gcactctgc  gctcagggt  600
gggtatgnt  tggaaatat  aaacacttc  tggcgcatg  catattcca  cctcatagg  660
atctgnact  cactcctaa  taggctt  687



<210> 4269
<211> 325
<212> PRT
<213> Rattus norvegicus
<308> BC005620
<400> 4269

Met Ala Ala Ala Ala Ala Ser Leu Arg Arg Thr Val Leu Gly Pro Arg 
  1               5                  10                  15
Gly Val Gly Leu Pro Gly Ala Ser Ala Pro Gly Leu Leu Gly Gly Ala 
             20                  25                  30
Arg Ser Arg Gln Leu Pro Leu Arg Thr Pro Gln Ala Val Ser Leu Ser 
         35                  40                  45
Ser Lys Ser Gly Pro Ser Arg Gly Arg Lys Val Met Leu Ser Ala Leu 
     50                  55                  60
Gly Met Leu Ala Ala Gly Gly Ala Gly Leu Ala Val Ala Leu His Ser 
 65                  70                  75                  80
Ala Val Ser Ala Ser Asp Leu Glu Leu His Pro Pro Ser Tyr Pro Trp 
                 85                  90                  95
Ser His Arg Gly Leu Leu Ser Ser Leu Asp His Thr Ser Ile Arg Arg 
             100                105                110
Gly Phe Gln Val Tyr Lys Gln Val Cys Ser Ser Cys His Ser Met Asp 
         115                120                125
Tyr Val Ala Tyr Arg His Leu Val Gly Val Cys Tyr Thr Glu Glu Glu 
     130                135                140
Ala Lys Ala Leu Ala Glu Glu Val Glu Val Gln Asp Gly Pro Asn Asp 
 145                150                155                160
Asp Gly Glu Met Phe Met Arg Pro Gly Lys Leu Ser Asp Tyr Phe Pro 
                 165                170                175
Lys Pro Tyr Pro Asn Pro Glu Ala Ala Arg Ala Ala Asn Asn Gly Ala 
             180                185                190
Leu Pro Pro Asp Leu Ser Tyr Ile Val Arg Ala Arg His Gly Gly Glu 
         195                200                205
Asp Tyr Val Phe Ser Leu Leu Thr Gly Tyr Cys Glu Pro Pro Thr Gly 
     210                215                220
Val Ser Leu Arg Glu Gly Leu Tyr Phe Asn Pro Tyr Phe Pro Gly Gln 
 225                230                235                240
Ala Ile Gly Met Ala Pro Pro Ile Tyr Thr Glu Val Leu Glu Tyr Asp 
                 245                250                255
Asp Gly Thr Pro Ala Thr Met Ser Gln Val Ala Lys Asp Val Ala Thr 
             260                265                270
Phe Leu Arg Trp Ala Ser Glu Pro Glu His Asp His Arg Lys Arg Met 
         275                280                285
Gly Leu Lys Met Leu Leu Met Met Gly Leu Leu Leu Pro Leu Thr Tyr 
     290                295                300
Ala Met Lys Arg His Lys Trp Ser Val Leu Lys Ser Arg Lys Leu Ala 
 305                310                315                320
Tyr Arg Pro Pro Lys 
                 325



<210> 4270
<211> 761
<212> DNA
<213> Homo sapiens
<308> AA643228
<400> 4270

tttatgttg  gaaacttaa  ttattccca  actgagggc  gaaggaaga  cagaagcaa  60
agtctggtc  cctggccct  gtatctgat  aaaagggcc  ggcctgaga  gcagtcgga  120
tgttcctgg  ctgctgaga  cttgttctg  caagatgac  agcagatac  gaacagggt  180
acttgggtg  ccgataagc  agctttcga  tcttcagga  tgaccactt  tgccgcttc  240
tggcatagg  caggggcag  agcaggccc  tcatcaaca  catcttgag  cccatgcgt  300
ttcgatggt  atgctctgg  tctgatgcc  agcgaagga  ggtggcgac  tccttagct  360
cttgtgaca  ggtagctgg  gtgccatca  catactcca  gacttctgt  tagatggga  420
gagccatgc  aatggnctg  ccgggaaag  aagggttga  atagaggcc  tctcgcaat  480
acaccccag  ggggnnctc  cagtagcca  tgagcaggg  aaatacgta  tcctcacca  540
catgcctag  tcgaacgat  tagctgagg  cagggggta  agctccatt  ttagcagct  600
ttgcagcct  agggttagg  tatggtttt  gaaaatagt  agacaactg  cctggccgc  660
tgaacatct  cccatcatc  ttagggcca  cctggacct  cancttcct  agcagcgcc  720
ggcttcttc  tccgtgtag  acattccca  aggtggcgg  a  761



<210> 4271
<211> 325
<212> PRT
<213> Homo sapiens
<308> BC001006
<400> 4271

Met Ala Ala Ala Ala Ala Ser Leu Arg Gly Val Val Leu Gly Pro Arg 
  1               5                  10                  15
Gly Ala Gly Leu Pro Gly Ala Arg Ala Arg Gly Leu Leu Cys Ser Ala 
             20                  25                  30
Arg Pro Gly Gln Leu Pro Leu Arg Thr Pro Gln Ala Val Ala Leu Ser 
         35                  40                  45
Ser Lys Ser Gly Leu Ser Arg Gly Arg Lys Val Met Leu Ser Ala Leu 
     50                  55                  60
Gly Met Leu Ala Ala Gly Gly Ala Gly Leu Ala Val Ala Leu His Ser 
 65                  70                  75                  80
Ala Val Ser Ala Ser Asp Leu Glu Leu His Pro Pro Ser Tyr Pro Trp 
                 85                  90                  95
Ser His Arg Gly Leu Leu Ser Ser Leu Asp His Thr Ser Ile Arg Arg 
             100                105                110
Gly Phe Gln Val Tyr Lys Gln Val Cys Ala Ser Cys His Ser Met Asp 
         115                120                125
Phe Val Ala Tyr Arg His Leu Val Gly Val Cys Tyr Thr Glu Asp Glu 
     130                135                140
Ala Lys Glu Leu Ala Ala Glu Val Glu Val Gln Asp Gly Pro Asn Glu 
 145                150                155                160
Asp Gly Glu Met Phe Met Arg Pro Gly Lys Leu Phe Asp Tyr Phe Pro 
                 165                170                175
Lys Pro Tyr Pro Asn Ser Glu Ala Ala Arg Ala Ala Asn Asn Gly Ala 
             180                185                190
Leu Pro Pro Asp Leu Ser Tyr Ile Val Arg Ala Arg His Gly Gly Glu 
         195                200                205
Asp Tyr Val Phe Ser Leu Leu Thr Gly Tyr Cys Glu Pro Pro Thr Gly 
     210                215                220
Val Ser Leu Arg Glu Gly Leu Tyr Phe Asn Pro Tyr Phe Pro Gly Gln 
 225                230                235                240
Ala Ile Ala Met Ala Pro Pro Ile Tyr Thr Asp Val Leu Glu Phe Asp 
                 245                250                255
Asp Gly Thr Pro Ala Thr Met Ser Gln Ile Ala Lys Asp Val Cys Thr 
             260                265                270
Phe Leu Arg Trp Ala Ser Glu Pro Glu His Asp His Arg Lys Arg Met 
         275                280                285
Gly Leu Lys Met Leu Met Met Met Ala Leu Leu Val Pro Leu Val Tyr 
     290                295                300
Thr Ile Lys Arg His Lys Trp Ser Val Leu Lys Ser Arg Lys Leu Ala 
 305                310                315                320
Tyr Arg Pro Pro Lys 
                 325



<210> 4272
<211> 633
<212> DNA
<213> Rattus norvegicus
<308> AA799475
<400> 4272

aaacactgc  ttgcactca  atttattgc  ataattgtg  tatggagtc  gaagatcaa  60
ctgggttct  agtcccctg  cctcaccca  tgtgccact  gttatgcct  tccccaccc  120
ctgtacacg  acacacaaa  tggacttgt  ctcctcagt  gtgatgcag  caacatatc  180
ggacgccta  tatatcaaa  gctgaatga  gggaatcag  gggccagac  atagggagc  240
gtggggtgt  caggtggcc  ccattgcta  agacccagg  tggtctccc  ctgattcat  300
agtcatgtt  atcccctgg  tgctgggga  ggtggtgtc  gtggcttca  cttgccgag  360
tgaaggatg  agactgaac  gctgagctg  gtcctcagc  accctgagc  tgaagccgc  420
gcatctgca  gatctgact  agaatgcac  gtacatcct  gtccatctg  ccctgaatg  480
cgtacaaga  atgggtgcg  tataaagcc  cacagtgca  tgttcctgg  cctcctcct  540
tatctgctg  tgcaaggct  tcacctnga  acgcagggg  ntctcctgc  ccttgganc  600
ggctggatt  gactgctgc  ccttcaaaa  ctc  633



<210> 4273
<211> 848
<212> DNA
<213> Homo sapiens
<308> BI769995
<400> 4273

ccacgggca  ggaggccgc  cggctgcgc  cggagctgg  gcgggagcg  gtgtgcagc  60
tggcgctct  ggagcacga  cgcatcgtg  gcaccctgc  ggccaacgt  gcccagctg  120
aggggcagc  ggaggagct  ggacggcgg  atgagaaga  cagcgcaga  gtcttccag  180
tgcagcgtg  ggccctgtt  atgaagagt  agcgacacg  agccgaggc  cagctggcc  240
cagcagagc  gcagctacg  gggctacgg  ccgaggcgg  aagggctcg  caggcccag  300
gccgggccc  ggaggctct  gacaaggcc  aggagaagg  caagaagat  acagaactc  360
ccaaagaag  cttcaatct  aaggaagcc  tgaaggagc  gccggccgc  tcgccaccc  420
tgaggtgga  gctctccgt  accaggtga  ggatttaca  cagcagctg  aggaagctg  480
cagggacca  tccagcgtg  tggctttgt  cagaagcca  ctcctatat  ccattcagg  540
ccagatgga  gaagatgtg  agcggattc  cagccagat  ctgcagatg  agagactcc  600
ggctcaggg  cgctgagaa  ggccaggcc  agtggctac  ctgaccaca  ccacgcagg  660
acctcaacc  cctgcaggc  ccttgcaga  cggcttcac  tggcttcac  tggccctat  720
caggcccat  cacttggag  ccagcctgg  tccctgccc  aacacccca  gtgggctcc  780
tcacccaac  ggtctctga  acgcacaca  tggtcagtc  tgacccggg  cgttgatgc  840
ctccccta  848



<210> 4274
<211> 681
<212> DNA
<213> Rattus norvegicus
<308> AA799479
<400> 4274

gggatcaga  tttctttat  ggctatagg  gccacaagg  tggccaggt  gcaaggtca  60
cggtggccc  gtcaccgat  caggtagtc  gcctggatg  tggccgcga  ctcggcctc  120
cacttgtca  cattgttga  tagcttctc  ttgttgtac  gcaactcct  atgcgtctc  180
gtggaaaac  caaagttgg  gccctccac  atagcgtca  cagggcagg  ttcctggca  240
aaaccacag  acatacact  ggtcatgtc  atgtcatag  gtgtagtcc  gcggctgcc  300
tctgctctt  gctcagcct  aatggtgat  gcctgtgca  gacagatgg  ctcacagag  360
ttgcaggcg  tgcaacgct  ctccccagt  cggtatcgg  gcagtgcat  ctccccacg  420
aagcgcgga  tcagtgggc  cttctcaaa  gggtacttg  tggtggccg  ctcccgaaa  480
gagtaccta  ggtcatgcc  agtctcgga  gagtccgtc  catcagaac  gaactgcat  540
tcatcccag  ttctagtca  aaaattcgg  gccttcaat  aatactgtt  gtacggcca  600
gaagctaga  gtttgcaat  aaatccgtc  aggccggca  ggcgggaaa  tcaaccagg  660
gaatctaat  acccccgca  t  681



<210> 4275
<211> 747
<212> DNA
<213> Homo sapiens
<308> U65579
<400> 4275

ctggcctgc  tggcaaggc  agtagcggc  gcgcttcaa  atgcgctgc  tgaccacgc  60
tatgctgct  cgggccctg  cccaggctg  acgtgcagg  cctcctggt  gccggagcc  120
ccacagcag  gcagtggca  ccacctaca  gtatgtgaa  atgcaggat  ccgagatgg  180
catgaagtc  gtgactgac  gggcagccc  caccctgct  tggactgag  tcttccgag  240
cctgggcat  accctgagc  acctgttcc  ggaaccggc  accatcaac  acccgttcg  300
gaagggccc  ctgagccct  gcttccgtg  ggagcatgc  ctgcgccgg  acccatccg  360
ggaggagcg  tgcattgcc  gcaagctct  cgaggccat  tgccccgcc  aggccatca  420
catcgaggc  gagccaaga  ctgatggca  ccgccggac  acccgctat  acatcgaca  480
gaccaagtg  atctactgc  gcttctgcc  ggaggcctg  cccgtggat  ccatcgtcg  540
gggccccaa  tttgagttc  ccacggaga  ccatgagga  ctgctgtac  acaaggaga  600
gttgctcaa  aacggggac  agtgggagg  cgagatcgc  gccaacatc  aggctgact  660
cttgtatcg  tgacgcccc  ccggcccgc  gcccctgct  cccaataaa  ccactccga  720
cccacggaa  aaaaaaaaa  aaaaaaa  747



<210> 4276
<211> 210
<212> PRT
<213> Homo sapiens
<308> O00217
<400> 4276

Met Arg Cys Leu Thr Thr Pro Met Leu Leu Arg Ala Leu Ala Gln Ala 
  1               5                  10                  15
Ala Arg Ala Gly Pro Pro Gly Gly Arg Ser Leu His Ser Ser Ala Val 
             20                  25                  30
Ala Ala Thr Tyr Lys Tyr Val Asn Met Gln Asp Pro Glu Met Asp Met 
         35                  40                  45
Lys Ser Val Thr Asp Arg Ala Ala Arg Thr Leu Leu Trp Thr Glu Leu 
     50                  55                  60
Phe Arg Gly Leu Gly Met Thr Leu Ser Tyr Leu Phe Arg Glu Pro Ala 
 65                  70                  75                  80
Thr Ile Asn Tyr Pro Phe Glu Lys Gly Pro Leu Ser Pro Arg Phe Arg 
                 85                  90                  95
Gly Glu His Ala Leu Arg Arg Tyr Pro Ser Gly Glu Glu Arg Cys Ile 
             100                105                110
Ala Cys Lys Leu Cys Glu Ala Ile Cys Pro Ala Gln Ala Ile Thr Ile 
         115                120                125
Glu Ala Glu Pro Arg Ala Asp Gly Ser Arg Arg Thr Thr Arg Tyr Asp 
     130                135                140
Ile Asp Met Thr Lys Cys Ile Tyr Cys Gly Phe Cys Gln Glu Ala Cys 
 145                150                155                160
Pro Val Asp Ala Ile Val Glu Gly Pro Asn Phe Glu Phe Ser Thr Glu 
                 165                170                175
Thr His Glu Glu Leu Leu Tyr Asn Lys Glu Lys Leu Leu Asn Asn Gly 
             180                185                190
Asp Lys Trp Glu Ala Glu Ile Ala Ala Asn Ile Gln Ala Asp Tyr Leu 
         195                200                205
Tyr Arg 
     210



<210> 4277
<211> 681
<212> DNA
<213> Rattus norvegicus
<308> AA799479
<400> 4277

gggatcaga  tttctttat  ggctatagg  gccacaagg  tggccaggt  gcaaggtca  60
cggtggccc  gtcaccgat  caggtagtc  gcctggatg  tggccgcga  ctcggcctc  120
cacttgtca  cattgttga  tagcttctc  ttgttgtac  gcaactcct  atgcgtctc  180
gtggaaaac  caaagttgg  gccctccac  atagcgtca  cagggcagg  ttcctggca  240
aaaccacag  acatacact  ggtcatgtc  atgtcatag  gtgtagtcc  gcggctgcc  300
tctgctctt  gctcagcct  aatggtgat  gcctgtgca  gacagatgg  ctcacagag  360
ttgcaggcg  tgcaacgct  ctccccagt  cggtatcgg  gcagtgcat  ctccccacg  420
aagcgcgga  tcagtgggc  cttctcaaa  gggtacttg  tggtggccg  ctcccgaaa  480
gagtaccta  ggtcatgcc  agtctcgga  gagtccgtc  catcagaac  gaactgcat  540
tcatcccag  ttctagtca  aaaattcgg  gccttcaat  aatactgtt  gtacggcca  600
gaagctaga  gtttgcaat  aaatccgtc  aggccggca  ggcgggaaa  tcaaccagg  660
gaatctaat  acccccgca  t  681



<210> 4278
<211> 747
<212> DNA
<213> Homo sapiens
<308> U65579
<400> 4278

ctggcctgc  tggcaaggc  agtagcggc  gcgcttcaa  atgcgctgc  tgaccacgc  60
tatgctgct  cgggccctg  cccaggctg  acgtgcagg  cctcctggt  gccggagcc  120
ccacagcag  gcagtggca  ccacctaca  gtatgtgaa  atgcaggat  ccgagatgg  180
catgaagtc  gtgactgac  gggcagccc  caccctgct  tggactgag  tcttccgag  240
cctgggcat  accctgagc  acctgttcc  ggaaccggc  accatcaac  acccgttcg  300
gaagggccc  ctgagccct  gcttccgtg  ggagcatgc  ctgcgccgg  acccatccg  360
ggaggagcg  tgcattgcc  gcaagctct  cgaggccat  tgccccgcc  aggccatca  420
catcgaggc  gagccaaga  ctgatggca  ccgccggac  acccgctat  acatcgaca  480
gaccaagtg  atctactgc  gcttctgcc  ggaggcctg  cccgtggat  ccatcgtcg  540
gggccccaa  tttgagttc  ccacggaga  ccatgagga  ctgctgtac  acaaggaga  600
gttgctcaa  aacggggac  agtgggagg  cgagatcgc  gccaacatc  aggctgact  660
cttgtatcg  tgacgcccc  ccggcccgc  gcccctgct  cccaataaa  ccactccga  720
cccacggaa  aaaaaaaaa  aaaaaaa  747



<210> 4279
<211> 210
<212> PRT
<213> Homo sapiens
<308> O00217
<400> 4279

Met Arg Cys Leu Thr Thr Pro Met Leu Leu Arg Ala Leu Ala Gln Ala 
  1               5                  10                  15
Ala Arg Ala Gly Pro Pro Gly Gly Arg Ser Leu His Ser Ser Ala Val 
             20                  25                  30
Ala Ala Thr Tyr Lys Tyr Val Asn Met Gln Asp Pro Glu Met Asp Met 
         35                  40                  45
Lys Ser Val Thr Asp Arg Ala Ala Arg Thr Leu Leu Trp Thr Glu Leu 
     50                  55                  60
Phe Arg Gly Leu Gly Met Thr Leu Ser Tyr Leu Phe Arg Glu Pro Ala 
 65                  70                  75                  80
Thr Ile Asn Tyr Pro Phe Glu Lys Gly Pro Leu Ser Pro Arg Phe Arg 
                 85                  90                  95
Gly Glu His Ala Leu Arg Arg Tyr Pro Ser Gly Glu Glu Arg Cys Ile 
             100                105                110
Ala Cys Lys Leu Cys Glu Ala Ile Cys Pro Ala Gln Ala Ile Thr Ile 
         115                120                125
Glu Ala Glu Pro Arg Ala Asp Gly Ser Arg Arg Thr Thr Arg Tyr Asp 
     130                135                140
Ile Asp Met Thr Lys Cys Ile Tyr Cys Gly Phe Cys Gln Glu Ala Cys 
 145                150                155                160
Pro Val Asp Ala Ile Val Glu Gly Pro Asn Phe Glu Phe Ser Thr Glu 
                 165                170                175
Thr His Glu Glu Leu Leu Tyr Asn Lys Glu Lys Leu Leu Asn Asn Gly 
             180                185                190
Asp Lys Trp Glu Ala Glu Ile Ala Ala Asn Ile Gln Ala Asp Tyr Leu 
         195                200                205
Tyr Arg 
     210



<210> 4280
<211> 673
<212> DNA
<213> Rattus norvegicus
<308> AA799481
<400> 4280

ccatcacaa  aaaagtgac  cagctttac  aaaataaat  tttattaaa  gcagtaaag  60
ctgagcagg  agacagtac  aagaatgta  acaatgtaa  caccactac  ttcagctca  120
cctgatcgg  tgctgaaag  caagtctaa  tgctctagt  cctttgcta  caagataca  180
taattctat  ttacacaga  aacatattc  aatttttac  agggaaaaa  agtttatcg  240
agtcgatcc  aacgccaaa  gctggcatc  tcgcagaca  ctatgagga  gctgctatc  300
ctgctaaaa  tggtttgtc  aatagcagc  ccacattta  gatgggtca  tgttgtgca  360
ttggcttta  gaggatctt  tactttcaa  tcccaaaca  acagtttga  aacctgact  420
cccaatgca  gcattaggt  tactttaac  atatcatcc  caatttggc  ggtttcaac  480
aaaaaggca  tttcacaaa  ctgggaaat  caaaacgcc  aacatcctt  aaatcaaca  540
aatccaagt  gtccgggta  aaaatcggg  atggatttc  ggaataaag  ccggaagtt  600
gttgggtaa  accaaaatc  taaccatca  aatccttgg  ggtctcaaa  tagagggtc  660
acccgggaa  att  673



<210> 4281
<211> 441
<212> PRT
<213> Rattus norvegicus
<308> NP_068676
<400> 4281

Met Ser Glu Arg Glu Val Ser Thr Ala Pro Ala Gly Thr Asp Met Pro 
  1               5                  10                  15
Ala Ala Lys Lys Gln Lys Leu Ser Ser Asp Glu Asn Ser Asn Pro Asp 
             20                  25                  30
Leu Ser Gly Asp Glu Asn Asp Asp Ala Val Ser Ile Glu Ser Gly Thr 
         35                  40                  45
Asn Thr Glu Arg Pro Asp Thr Pro Thr Asn Thr Pro Asn Ala Pro Gly 
     50                  55                  60
Arg Lys Ser Trp Gly Lys Gly Lys Trp Lys Ser Lys Lys Cys Lys Tyr 
 65                  70                  75                  80
Ser Phe Lys Cys Val Asn Ser Leu Lys Glu Asp His Asn Gln Pro Leu 
                 85                  90                  95
Phe Gly Val Gln Phe Asn Trp His Ser Lys Glu Gly Asp Pro Leu Val 
             100                105                110
Phe Ala Thr Val Gly Ser Asn Arg Val Thr Leu Tyr Glu Cys His Ser 
         115                120                125
Gln Gly Glu Ile Arg Leu Leu Gln Ser Tyr Val Asp Ala Asp Ala Asp 
     130                135                140
Glu Asn Phe Tyr Thr Cys Ala Trp Thr Tyr Asp Ser Asn Thr Ser His 
 145                150                155                160
Pro Leu Leu Ala Val Ala Gly Ser Arg Gly Ile Ile Arg Ile Ile Asn 
                 165                170                175
Pro Ile Thr Met Gln Cys Ile Lys His Tyr Val Gly His Gly Asn Ala 
             180                185                190
Ile Asn Glu Leu Lys Phe His Pro Arg Asp Pro Asn Leu Leu Leu Ser 
         195                200                205
Val Ser Lys Asp His Ala Leu Arg Leu Trp Asn Ile Gln Thr Asp Thr 
     210                215                220
Leu Val Ala Ile Phe Gly Gly Val Glu Gly His Arg Asp Glu Val Leu 
 225                230                235                240
Ser Ala Asp Tyr Asp Leu Leu Gly Glu Lys Ile Met Ser Cys Gly Met 
                 245                250                255
Asp His Ser Leu Lys Leu Trp Arg Ile Asn Ser Lys Arg Met Met Asn 
             260                265                270
Ala Ile Lys Glu Ser Tyr Asp Tyr Asn Pro Asn Lys Thr Asn Arg Pro 
         275                280                285
Phe Ile Ser Gln Lys Ile His Phe Pro Asp Phe Ser Thr Arg Asp Ile 
     290                295                300
His Arg Asn Tyr Val Asp Cys Val Arg Trp Leu Gly Asp Leu Ile Leu 
 305                310                315                320
Ser Lys Ser Cys Glu Asn Ala Ile Val Cys Trp Lys Pro Gly Lys Met 
                 325                330                335
Glu Asp Asp Ile Asp Lys Ile Lys Pro Ser Glu Ser Asn Val Thr Ile 
             340                345                350
Leu Gly Arg Phe Asp Tyr Ser Gln Cys Asp Ile Trp Tyr Met Arg Phe 
         355                360                365
Ser Met Asp Phe Trp Gln Lys Met Leu Ala Leu Gly Asn Gln Val Gly 
     370                375                380
Lys Leu Tyr Val Trp Asp Leu Glu Val Glu Asp Pro His Lys Ala Lys 
 385                390                395                400
Cys Thr Thr Leu Thr His His Lys Cys Gly Ala Ala Ile Arg Gln Thr 
                 405                410                415
Ser Phe Ser Arg Asp Ser Ser Ile Leu Ile Ala Val Cys Asp Asp Ala 
             420                425                430
Ser Ile Trp Arg Trp Asp Arg Leu Arg 
         435                440



<210> 4282
<211> 2032
<212> DNA
<213> Homo sapiens
<308> AF099032
<400> 4282

tttgcggca  gctcgggcc  ggcttgctt  acggcggtg  ggcggaggc  ccgccccag  60
cggcaggaa  ctggaggga  gcggaggaa  atgtccgag  gggaagtgt  gactgcgcc  120
gcgggaaca  acatgcctg  ggccaagaa  cagaagctg  gcagtgacg  gaacagcaa  180
ccagacctc  ctggagacg  gaatgatga  gctgtcagt  tagaaagtg  tacaaacac  240
gaacgccct  atacaccta  aaacacgcc  aatgcacct  gaaggaaaa  ttggggaaa  300
ggaaaatgg  gttcaaaga  atgcaaata  tctttcaaa  gtgtaaata  tctcaagga  360
gatcataac  aaccattgt  tggagttca  tttaactgg  acagtaaag  aggagatcc  420
ttagtgttt  caactgtag  aagcaacag  gttaccttg  atgaatgtc  ttcacaagg  480
gaaatccgg  tgttgcaat  ttacgtgga  gctgatgct  atgaaaact  ttacacttg  540
gcatggacc  atgatagca  tacgagcca  cctctgctg  ctgtagctg  atctagagg  600
ataattagg  taataaatc  tataacaat  cagtgtata  agcactatg  tggccatgg  660
aatgctatc  atgagctga  attccatcc  agagatcca  atcttctct  gtcagtaag  720
aaagatcat  ctttacgat  atggaatat  cagacggac  ctctggtgg  aatatttgg  780
ggcgtagaa  ggcacagag  tgaagttct  agtgctgat  atgatcttt  gggtgaaaa  840
ataatgtcc  gtggtatgg  tcattctct  aaactttgg  ggatcaatt  aaagagaat  900
atgaatgca  ttaaggaat  ttatgatta  aatccaaat  aaactaaca  gccatttat  960
tctcagaaa  tccattttc  tgatttttc  accagagac  tacatagga  ttatgttga  1020
tgtgtgcga  ggttaggcg  tttgatact  tctaagtct  gtgaaaatg  cattgtgtg  1080
tggaaacct  gcaagatga  agatgatat  gataaaatt  aacccagtg  atctaatgt  1140
actattctt  ggcgatttg  ttacagcca  tgtgacatt  ggtacatga  gttttctat  1200
gatttctgg  aaaagatgc  tgcattggg  aatcaagtt  gcaaacttt  tgtttggga  1260
ttagaagta  aagatcctc  taaagccaa  taagtattt  gaaatttct  ttcaaaatt  1320
caggctttt  ctccacact  gtatgccaa  gtagagaag  tcatttata  ttgcagtgc  1380
atccttaag  catttttaa  atttactgt  ttcagagtt  aagttattc  tttttattc  1440
aataatttt  gtttttcct  agtaccttg  tgacaagtc  tttcttgtt  ttatacaaa  1500
tatgtagtg  ttgttgaac  taaaatata  ctaaatttt  taaaatttg  gactgagct  1560
ttagtgaag  atattctgg  tttaagtgc  tttcgtatg  cttggaaca  ctgcttatt  1620
tctaatccg  tgttttagg  tagacactg  caacgttat  tgtggtctt  aacctgttg  1680
catgttttt  ccctagatg  acaacactg  ctcatcata  atgtggtgc  gctattcga  1740
aaaccagtt  tagcaggga  agcagcatt  ttatagctg  ttgtgatga  gccagtatt  1800
ggcgctggg  tcgacttcg  taaaatact  tgcctaatc  aaattagag  gtgtttgtt  1860
tctgtgtaa  atagaatta  tgtatcttg  tagtaaggg  acgtagagc  tttagagtt  1920
tctttcagc  ttcaatcag  ctgagctga  tgtagtgat  tttacattg  ttacattct  1980
tgtactgtc  tcctgctca  actctactg  ttttaataa  aatttattt  tg  2032



<210> 4283
<211> 401
<212> PRT
<213> Homo sapiens
<308> AF099032
<400> 4283

Met Ser Glu Arg Glu Val Ser Thr Ala Pro Ala Gly Thr Asp Met Pro 
  1               5                  10                  15
Ala Ala Lys Lys Gln Lys Leu Ser Ser Asp Glu Asn Ser Asn Pro Asp 
             20                  25                  30
Leu Ser Gly Asp Glu Asn Asp Asp Ala Val Ser Ile Glu Ser Gly Thr 
         35                  40                  45
Asn Thr Glu Arg Pro Asp Thr Pro Thr Asn Thr Pro Asn Ala Pro Gly 
     50                  55                  60
Arg Lys Ser Trp Gly Lys Gly Lys Trp Ser Ser Lys Lys Cys Lys Tyr 
 65                  70                  75                  80
Ser Phe Lys Cys Val Asn Ser Leu Lys Glu Asp His Asn Gln Pro Leu 
                 85                  90                  95
Phe Gly Val Gln Phe Asn Trp His Ser Lys Glu Gly Asp Pro Leu Val 
             100                105                110
Phe Ala Thr Val Gly Ser Asn Arg Val Thr Leu Tyr Glu Cys His Ser 
         115                120                125
Gln Gly Glu Ile Arg Leu Leu Gln Ser Tyr Val Asp Ala Asp Ala Asp 
     130                135                140
Glu Asn Phe Tyr Thr Cys Ala Trp Thr Tyr Asp Ser Asn Thr Ser His 
 145                150                155                160
Pro Leu Leu Ala Val Ala Gly Ser Arg Gly Ile Ile Arg Ile Ile Asn 
                 165                170                175
Pro Ile Thr Met Gln Cys Ile Lys His Tyr Val Gly His Gly Asn Ala 
             180                185                190
Ile Asn Glu Leu Lys Phe His Pro Arg Asp Pro Asn Leu Leu Leu Ser 
         195                200                205
Val Ser Lys Asp His Ala Leu Arg Leu Trp Asn Ile Gln Thr Asp Thr 
     210                215                220
Leu Val Ala Ile Phe Gly Gly Val Glu Gly His Arg Asp Glu Val Leu 
 225                230                235                240
Ser Ala Asp Tyr Asp Leu Leu Gly Glu Lys Ile Met Ser Cys Gly Met 
                 245                250                255
Asp His Ser Leu Lys Leu Trp Arg Ile Asn Ser Lys Arg Met Met Asn 
             260                265                270
Ala Ile Lys Glu Ser Tyr Asp Tyr Asn Pro Asn Lys Thr Asn Arg Pro 
         275                280                285
Phe Ile Ser Gln Lys Ile His Phe Pro Asp Phe Ser Thr Arg Asp Ile 
     290                295                300
His Arg Asn Tyr Val Asp Cys Val Arg Trp Leu Gly Asp Leu Ile Leu 
 305                310                315                320
Ser Lys Ser Cys Glu Asn Ala Ile Val Cys Trp Lys Pro Gly Lys Met 
                 325                330                335
Lys Asp Asp Ile Asp Lys Ile Lys Pro Ser Glu Ser Asn Val Thr Ile 
             340                345                350
Leu Gly Arg Phe Asp Tyr Ser Gln Cys Asp Ile Trp Tyr Met Arg Phe 
         355                360                365
Ser Met Asp Phe Trp Gln Lys Met Leu Ala Leu Gly Asn Gln Val Gly 
     370                375                380
Lys Leu Tyr Val Trp Asp Leu Glu Val Glu Asp Pro His Lys Ala Lys 
 385                390                395                400
Ter 
                 405



<210> 4284
<211> 737
<212> DNA
<213> Rattus norvegicus
<308> AA799487
<400> 4284

aggataaaa  ctcatttat  tcaaagagc  ggtacaatc  agacaagaa  tggccacgg  60
acaatcaca  tcgtcttaa  aaataacaa  acgccattt  tgtctctta  aatctatat  120
atacattat  catttaaaa  aaataaatc  ctgtgggtc  agaaacagc  ccggtgtct  180
ggacaagag  gatggctat  taagaccca  tgctcttgg  taaccaaca  agtcccctc  240
ccagccact  tgctctctc  cggttcttc  ggggaccgt  gcacacgcc  gtgcttcgg  300
actggcctt  ctagtgccc  tgccttgtt  gggggggct  attgcttcg  agacattcc  360
atcttgaca  ggtcggtac  gagcatggc  ctccgtgac  gccgggcgt  gactccatc  420
ccgtctctg  ctgggactg  gttttccca  gctgtcggt  ggttgctga  acatccgtg  480
gcgacacgt  ttctccttt  atnccaaac  ttcggggaa  tgcngggca  gatggctgg  540
actcacagg  tatataaca  tcgcgctgg  tacctgana  gggtgggct  cctgggtgc  600
gcaagctaa  cctaccggt  actgtgcaa  ctagaagtc  gtggctaaa  ggaattacc  660
cggcagcct  ggctggtgg  cactggtct  gccgttagg  actcntgcc  atttggctc  720
ggtcaattc  aatggtc  737



<210> 4285
<211> 654
<212> DNA
<213> Rattus norvegicus
<308> AA799488
<400> 4285

acaaaggat  ttaattcat  ccacttaaa  aataaaggt  gtctcctca  cccccataa  60
gagtacatt  agcacatat  cacatacag  aaatgtacg  acattcaat  gtttacaag  120
tttgtcacc  tgtaatcca  tgacattca  gtgaagtag  tgaacttat  tacatgtat  180
tatttggaa  ttctgtacc  catccatcc  tttttaaac  accaagata  tacgtctat  240
ctctagaag  cagttcata  aggatgatt  aaggttaga  gtctctttt  aagaattac  300
atgaagtat  tatacaata  gggctcaga  cttctaaac  caagcttga  gctacagct  360
actacctta  gttacatca  atccagtgt  tgggatttt  ttttagcag  ctgtttagt  420
tgtaagcca  ttcaaatgt  tcaaacaat  acttgtgca  caaggagaa  aagtacaaa  480
agaatgatt  cttcctttt  tttttatat  agataaaat  acatatcat  taatccttc  540
caaatccaa  attgtaaca  attactacg  aatgttcaa  ttgagtttc  gggaatcaa  600
atcactaac  agatgaaaa  agaatttca  ggtaccaaa  aaagccgcc  ttaa  654



<210> 4286
<211> 2799
<212> DNA
<213> Homo sapiens
<308> AK025159
<400> 4286

tatgactgt  taaaatatg  tgtccagca  aatggttcc  tgaaattag  aaacacaat  60
gaattatat  ggctttcga  ggcattagc  gatattgtt  tccctcagg  atatggtat  120
actaaagct  aaaaactgg  gattgccaa  ggctactgt  ctcctctgg  tagaaaaat  180
cgctcagac  ttcagagga  acaagatga  gacactgta  ataaacttc  tcctgtgta  240
tctagaggt  ttctgtctc  tgaacgtca  gttcgtact  gattatatt  taccagtga  300
agtcatgta  attctttgc  gtctattct  cgctatggt  ccttatgca  tgaatcaaa  360
gatgaacag  ggaaacgag  tatggatta  ttaaacgtt  tcaatgagc  caactacat  420
actcagatt  ttatcatgc  ttatgagga  cctaataag  atctttcct  agaagaacg  480
tttcatgtt  aattacact  tagtccggg  gccaaaggt  gtgaagaag  caaaaattt  540
ccatctggc  atggatata  accagcttc  agagagaat  aaggcagga  accttttaa  600
attgataat  atgatgaac  acatacttc  aaaagagat  aagttgatc  agctgtgat  660
ttgtttaaa  caatggtat  agagccaat  catatacac  ggaagtctc  acttccaag  720
tctaggaag  cggctacaa  tgatgttgt  tctgaaaat  ctaattacc  gagaacacc  780
agaactctt  tggaacaga  gcagaatcc  actgtaggc  ttgaattgt  ttccatggt  840
ccatctatt  gtcctctag  aactcttca  aatgcccta  ctttaaagc  agtggatga  900
tttcttgct  ccattgctt  tccatcatc  gacgttcca  ggaagaccg  tgaaatttc  960
tctacagct  tacgttcca  tccaataat  agaaaaaaa  tatctttaa  tacgtatac  1020
cctgcaaag  tcctcccaa  accaccagc  accttaaag  gcactaaag  aagcagcaa  1080
ccagctaca  gtggacctt  tagtgcagt  gttcctaat  cctcatctc  gaaaaagaa  1140
ataactagc  aaacagaaa  gcatgaaca  aaaaaaaac  ctgggaaaa  gaaatgaaa  1200
cttagcaga  gctggaact  tttatactt  taaaaatag  atgttctta  gtttctcct  1260
atgcattta  gtgttcact  aaaaatgtt  ttaaatcta  ggttttctt  gtttatgtt  1320
aggtaagga  ctgttgtca  gatctggaa  tgtttaaaa  aatgtttgt  agcattctg  1380
gagcagcaa  acttatagt  ataaaaatc  attgttgtt  atatgatgt  taccatgtg  1440
acatagtaa  gaaaaggaa  ataaaagcc  agcaggctc  taccaaagt  acagcagta  1500
tgctatgta  tgcagagtc  gatgagctg  cctttgtgc  cacttttat  ttcatggga  1560
tgcatctta  ctgttaaaa  ttctagatt  aaatttgac  gccagggtt  catattggg  1620
acttttaaa  tgtctttcc  aagagattt  attaaccgt  tagattaga  tatctttcc  1680
aattgttac  gtgacatat  tgctgcaat  tttaacaac  ggagtatta  ccacatggg  1740
tattttttc  atctgtgtt  tgaattttt  tattgtgtg  tatttaaaa  attacatat  1800
cagctggga  aactacacc  ttgtgcaca  agatttata  attaatttg  agaaaatat  1860
ttctttata  atttcctta  catacaagg  gccttgttc  tcaggaaaa  ttttgtttt  1920
tattttgac  agaaaggca  cttcagagt  tctttttaa  tatagttga  aagtgtata  1980
atgttacac  tactttcag  gttcttttt  gatctaaag  agtcagttc  aaaatggaa  2040
tcaacaatg  taggagaaa  ctgaattct  ttaagttag  aagtattat  tatagcatc  2100
gtttttaac  atttccatt  ttatcccta  tgtatcagt  gatcacact  agaaagctt  2160
aagattgag  atttgaaat  aatgctctt  ataaatgat  agatttttg  agggatatt  2220
aaatcattg  gctgtgatt  catctgtga  gtgaaaaat  aatttatta  ccttggtgc  2280
ttccccccc  ccaatgcac  aataattgt  aacagcttg  aatgactta  actgtaatc  2340
aaatgggac  atctgataa  aatttcatg  attggtagt  aaataactt  aattgctaa  2400
gctttagct  gaaatttat  tttagaaaa  ctattgatt  cccatggta  gaatataac  2460
attgtaatt  ttcaaatga  actcttctc  ccttaaata  tcatatatt  attaactta  2520
aggaaataa  catactata  gttagctgt  ttaaaaggt  ccagatgta  gagtcataa  2580
tatatgcaa  taaagaagt  catagattt  acatgaatg  aaatgtgtt  tatggagac  2640
tgtcttgta  acagttgaa  gtatgtaag  tttctgttt  tgaaaatgt  gttaatgta  2700
tcactgtgg  ggtcataag  aagctactt  ttttttaaa  tggaaccta  ttaaaatat  2760
tccagaatc  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2799



<210> 4287
<211> 513
<212> DNA
<213> Rattus norvegicus
<308> AA799497
<400> 4287

aaagccata  atggatggt  agagtaagc  gctgtacag  ggggacagc  tcagtgtac  60
tacattcat  tccagaaca  ttagcatac  tcagggttt  tacaaggtg  cagaggcta  120
aggcacaat  atacaaaat  taaagtata  ttccatcta  aaatacaca  ccggggact  180
ccctaggca  caatcctgg  tccatcagt  cccttctct  ccatctcac  tccaacctc  240
gatcttccg  gtggccgga  gctgtttgt  cctgggctg  tcctaaggg  tcttgttaa  300
ggcatcact  gccgccatg  tctcctgtc  cccctcccc  tctttcatt  ctgtctaag  360
atggacaac  ctctccctg  tgatataga  attcaacaa  aaacaacaa  atgacagat  420
attcacaaa  gagcagtgg  taaaagtgc  ctcgtttaa  ggaagtctt  ggcaagaat  480
cagagttgc  tacggagtg  tctgcctcg  gcc  513



<210> 4288
<211> 513
<212> DNA
<213> Rattus norvegicus
<308> AA799497
<400> 4288

aaagccata  atggatggt  agagtaagc  gctgtacag  ggggacagc  tcagtgtac  60
tacattcat  tccagaaca  ttagcatac  tcagggttt  tacaaggtg  cagaggcta  120
aggcacaat  atacaaaat  taaagtata  ttccatcta  aaatacaca  ccggggact  180
ccctaggca  caatcctgg  tccatcagt  cccttctct  ccatctcac  tccaacctc  240
gatcttccg  gtggccgga  gctgtttgt  cctgggctg  tcctaaggg  tcttgttaa  300
ggcatcact  gccgccatg  tctcctgtc  cccctcccc  tctttcatt  ctgtctaag  360
atggacaac  ctctccctg  tgatataga  attcaacaa  aaacaacaa  atgacagat  420
attcacaaa  gagcagtgg  taaaagtgc  ctcgtttaa  ggaagtctt  ggcaagaat  480
cagagttgc  tacggagtg  tctgcctcg  gcc  513



<210> 4289
<211> 565
<212> DNA
<213> Rattus norvegicus
<308> AA799499
<400> 4289

aatagttac  aaaaaccca  agtttttct  gctttatta  accatacag  attctttca  60
ggacagaca  acagccaag  atgctatgg  gagagaaat  ttattttca  ggaagacgt  120
acaggtgct  tcttcagtg  tgattctta  cctcatggg  agtcaggaa  tactcgggc  180
ctaaagcta  cataaacgc  gcaaacccc  atttgaatc  ttttaacat  acgctcgtg  240
acgtgatat  gtctgcaaa  ccgcccatg  atctccaag  ctcattgcg  gcccatgga  300
ccctcagcc  tcgtgcagc  agcttcttc  gcattgctt  aaatggcgt  acttcaatt  360
tccactgtc  gtaatctgg  agttccatt  taccatgac  atgtccgtg  tcgtgacca  420
gttcaggag  catgtctga  agaatgttg  cccccagga  accaatatt  aagcttccc  480
tcggccgga  tctggcctc  aggtcaatt  cctatgtgg  ccgattaaa  cgtagtcat  540
taaagtgtt  cgtgttaat  gttcc  565



<210> 4290
<211> 104
<212> PRT
<213> Rattus norvegicus
<308> NP_079873
<400> 4290

Met Ala Ala Gly His Gly His Glu His Gly His Glu His Gly His Gly 
  1               5                  10                  15
His Gly Lys Met Glu Leu Pro Asp Tyr Arg Gln Trp Lys Ile Glu Gly 
             20                  25                  30
Thr Pro Leu Glu Thr Val Gln Lys Lys Leu Ala Ala Arg Gly Leu Arg 
         35                  40                  45
Asp Pro Trp Ala Arg Asn Glu Ala Trp Arg Tyr Met Gly Gly Phe Ala 
     50                  55                  60
Gly Asn Ile Thr Phe Pro Ser Val Ile Leu Lys Gly Phe Lys Trp Gly 
 65                  70                  75                  80
Phe Ala Ala Phe Val Val Ala Leu Gly Ala Glu Tyr Phe Leu Asp Ser 
                 85                  90                  95
Gln Asn Gly Asp Lys Lys His His 
             100



<210> 4291
<211> 693
<212> DNA
<213> Homo sapiens
<308> AF047183
<400> 4291

tccccgccc  tctcttttc  acagtatct  ttacctcag  cagattgag  atgcacata  60
actgggaaa  taatcgact  ccagcgtcc  tcatgtagt  tctacctga  tcaggaatc  120
ctaacccag  atcggaacg  taagcggct  ctccgcttt  ctgccgtga  aaactcgag  180
tgaccaacc  ccgtttccg  ttggctccg  ttgcagagt  gagtgtcct  agaggtcag  240
ttgctgtca  acatggccc  tgaacatgg  catgagcat  gacatcata  aatggaact  300
ccagattat  gacaatgga  gatagaagg  acaccatta  aaactatcc  gaagaagct  360
gctgcaaaa  ggctaaggg  tccatgggg  cgcaatgaa  cttggagat  catgggtgg  420
tttgcaaag  gtgtttcct  ttctgatgt  ttctttaaa  gattcaaat  gggatttgc  480
gcatttgtg  tagctgtag  agctgaata  tacctggag  ccctgaata  agataagaa  540
catcactga  gataatacc  ggaagcatc  tagtggttt  ttaactctc  aaaataaga  600
ttcttctct  tagcctact  gtctggttt  tcccttaca  aatattagt  aagatttaa  660
caattaaaa  atatataaa  aaaaaaaaa  aaa  693



<210> 4292
<211> 97
<212> PRT
<213> Homo sapiens
<308> O43676
<400> 4292

Ala His Glu His Gly His Glu His Gly His His Lys Met Glu Leu Pro 
  1               5                  10                  15
Asp Tyr Arg Gln Trp Lys Ile Glu Gly Thr Pro Leu Glu Thr Ile Gln 
             20                  25                  30
Lys Lys Leu Ala Ala Lys Gly Leu Arg Asp Pro Trp Gly Arg Asn Glu 
         35                  40                  45
Ala Trp Arg Tyr Met Gly Gly Phe Ala Lys Ser Val Ser Phe Ser Asp 
     50                  55                  60
Val Phe Phe Lys Gly Phe Lys Trp Gly Phe Ala Ala Phe Val Val Ala 
 65                  70                  75                  80
Val Gly Ala Glu Tyr Tyr Leu Glu Ser Leu Asn Lys Asp Lys Lys His 
                 85                  90                  95
His 
             100



<210> 4293
<211> 777
<212> DNA
<213> Rattus norvegicus
<308> AA799501
<400> 4293

aatctagca  gttgcttag  aaggcttgt  gtgttgagt  caaatactc  tccagcatg  60
ctcctagag  ccatttcac  cactgctct  tttggctgc  agcctcttg  ctctctctt  120
agcaatggt  aggcggatt  cttttcctc  gggaagaga  atccacggt  tgttgccct  180
gccaataac  aaaatgttg  aaagacgag  ggcaaagct  ttgccgttg  catctttca  240
atgaaccac  tcaaaagag  caggatgtc  ctccctatt  gtgattaca  caattctcc  300
caagttagc  cctccagtc  ccatacaca  gttcccagt  tcgaacttg  tgaaatcag  360
tatcttgcc  gtttccaaa  caatctgaa  ggtgtcatt  accttgatg  ggggatcag  420
gtatcgaat  gtacgggca  catgggtca  cagatgtgg  attcccttt  tgcccacan  480
gatctttct  actttgcac  acttgtact  gggctcctc  ggtgtaatt  gatgaacag  540
aaagcgacc  ttggtgtca  agatcagac  gaatttctc  ccagtcttg  caatgcgga  600
gacatccat  aaaccaaca  ggtangtta  aatcggtcc  gaattttcc  tctaacctt  660
atgaatcgc  gcatgcaaa  ctttttaaa  caacctcca  tcaggcaat  cttaatcgg  720
tccttagga  atgattagg  caggattct  cacattgtg  ggacactgg  tgtccag  777



<210> 4294
<211> 115
<212> PRT
<213> Rattus norvegicus
<308> Q63362
<400> 4294

Ala Gly Leu Val Lys Lys Thr Thr Gly Leu Val Gly Leu Ala Val Cys 
  1               5                  10                  15
Asp Thr Pro His Glu Arg Leu Thr Ile Leu Tyr Thr Lys Ile Leu Asp 
             20                  25                  30
Leu Leu Lys His Phe Pro Lys His Ala Ala Tyr Arg Lys Tyr Thr Glu 
         35                  40                  45
Gln Ile Thr Ser Glu Lys Leu Glu Leu Val Lys Leu Glu Pro Asp Val 
     50                  55                  60
Lys Lys Leu Glu Asn Leu Leu Gln Gly Gly Glu Val Glu Glu Val Ile 
 65                  70                  75                  80
Leu Gln Ala Glu Lys Glu Leu Ser Leu Ala Arg Lys Met Leu Gln Trp 
                 85                  90                  95
Lys Pro Trp Glu Pro Leu Val Glu Glu Pro Pro Ala Asn Gln Trp Lys 
             100                105                110
Trp Pro Ile 
         115



<210> 4295
<211> 233
<212> DNA
<213> Homo sapiens
<308> AA083919
<400> 4295

tggattcat  gatgtcatc  gcattgaca  gacgggaga  aatttccgt  tgatctatg  60
caccaaggg  cgctttgct  tacatcgta  tacacctga  gaggccaag  acaagttgt  120
caaagtgag  aagatcttt  tgggcacaa  aggaatccc  ncatctngt  nngcctcat  180
attncccgc  acaatncgg  aacccgnat  ccctcatcn  ngngaatgn  acc  233



<210> 4296
<211> 707
<212> DNA
<213> Rattus norvegicus
<308> AA799507
<400> 4296

ccgttaaaa  tctaacatt  aactcaagg  tgagcacag  agctgctag  atatagaag  60
acagtcact  ggcagtgtg  cctcaagtc  tccagttgc  cacagaagg  cctcagaca  120
tgggctttc  tctagcctc  gtcttcaag  actttcgtg  tgggtccag  cacccgccc  180
caggtggct  caccaggac  tcactgcac  aagcgagaa  ggcttgtgc  gtaacatag  240
tactgggtt  ctgcccaca  tacttcctg  atcaacaga  cacagctga  aaacaccag  300
tcctgctgt  tggctgtca  gatggctag  agtagcccc  gaggctacc  cggtgagca  360
aagagagtg  cagtcaagg  taaggggaa  aggtggcac  agagggacc  ggaatttga  420
aagcttggg  tgctataaa  acatacacg  gagatgtgc  cacaaaata  aacttgtta  480
ataaaagtt  tacagaatc  agattaaac  tagtataaa  tagtctata  ggtataaga  540
gtagtgaaa  tataaagtt  caacatttg  atacgggca  ttccacaat  ggggtgcta  600
ggcaaggtg  tcccctacg  tggaaagca  tgggccacc  ctgaagcgt  cttggttcc  660
acccaaagt  acaacaaga  cagggttca  cgggaaagt  aataaac  707



<210> 4297
<211> 731
<212> DNA
<213> Rattus norvegicus
<308> AA799511
<400> 4297

gggtacaaa  gtatttatt  tataaaact  gtatttaaa  tagagctta  ctgtcaact  60
acaaatcct  atttaaaac  taacacatt  cccttagct  atctgatgt  aacctttac  120
atcaacacc  atttttgga  ttttattaa  aacctgtac  aaatgaagt  tttaatcag  180
aaacattcc  ttttacctt  aaagtgctt  ttaaatgaa  gcaccaaca  gaactactt  240
cagatggta  agaatttct  atttcttga  gactctgtg  ttgaccact  cttcattag  300
tacctgcag  aagacacct  ccattttac  accaacacc  ctgaaggaa  caagaaaag  360
tttattaat  atcacttgg  ttgcctcag  tgttgaaat  aagcacttt  cagtctttg  420
ggcaccaga  tatacttgt  catggttca  atcaatgcc  tgggaagtg  gaaaaactc  480
atacgggtt  ctccaccat  accccaatt  ctccactcc  ccaggacat  gttcctcca  540
cataggtcc  cccagtccg  aacaacaaa  ttcaccctc  tgacccttg  aaaggtgcg  600
tcngccgct  ggccaatct  gcccaggca  atcccaaag  ggccataat  caacaggca  660
cgttccggg  aatgttccg  caatccaaa  atacgggca  agtaaccgg  gccaaagtg  720
accacaatg  g  731



<210> 4298
<211> 1436
<212> DNA
<213> Homo sapiens
<308> AK026373
<400> 4298

tgtgttgtc  gcaattcat  aggattaaa  tatgtagat  acttaaggg  tatctctgc  60
aggagaaac  cctttttag  tcttttaga  gctgcttct  caatgcaag  aaaggaaat  120
accccagcg  ggtactctt  agggacaca  gtctagtac  agagaactc  tgacggcta  180
taagttcag  cagtcttaa  aaactgtgc  gtttctaca  aactttaac  acagtagtt  240
ataaggatg  caacgaaag  tgagggtgt  gagcaaaat  gttctaagc  tcagttaaa  300
ttctttagg  aagatctta  ttacttttc  tttcttaat  ttcctccct  aaagataaa  360
taatactct  aaatggtct  tcagtatag  ggttcttac  tagtttaac  tagctataa  420
ttgagttta  caatttata  actcaagag  ataattttt  taaaccctg  ttttcaatc  480
gtcatttac  taaattatt  tggttgttt  tcccttttt  tccttcttt  cccaccccc  540
ccccctcca  gtgaagatt  gggtgctta  catatcatt  ttttccctg  cggaatttt  600
gcattgata  gaaccatgg  caagtatat  ctgctgcca  aaagactgt  aagtgcttc  660
tttcaacag  tgaggcaag  caagtgatc  ttaataaag  ttttcttgg  tccttcagt  720
gtgttggta  taaaatggt  ggtaaaagt  aggctgcaa  ttcaataaa  catgagatt  780
cccatcgtt  cacccttgt  tattcacat  tcttggatc  aacattttg  gtgaactag  840
ggtttttat  aaagacatt  gttgtattt  tggttgtaa  tgtacatgc  tatcaggat  900
agactgaaa  aaggtaggg  aaaaatggt  gaatctatt  tcagatagt  gttcatact  960
gagtgaagt  tcttgtctg  attatgaag  ctggtatgt  tccagtact  aataggtgg  1020
ttaaatgtg  taattctag  tcagtgtct  accctgaag  gaaggttgt  ggttggctg  1080
tgaaattca  tccttagat  tgatcagtt  gattgcccg  ctttattgc  tttacagga  1140
tgtgatact  agggcttac  ctatacacc  atgagtctt  tttgatcct  agaccacca  1200
tgaagttgt  taggttctt  tggacaaac  tgataaact  cttcagata  ttttttttt  1260
ctttggcag  aaggtgtct  gctgcaggt  actaatgaa  aagtggtca  ccacagagt  1320
ttcaagaaa  aagaaattc  gtaccatct  aaagtagtt  ttgttggtg  cttcattta  1380
aaagcactc  ttaaaataa  agggaaatg  tttctgata  aaaaaaaaa  aaaaaa  1436



<210> 4299
<211> 731
<212> DNA
<213> Rattus norvegicus
<308> AA799511
<400> 4299

gggtacaaa  gtatttatt  tataaaact  gtatttaaa  tagagctta  ctgtcaact  60
acaaatcct  atttaaaac  taacacatt  cccttagct  atctgatgt  aacctttac  120
atcaacacc  atttttgga  ttttattaa  aacctgtac  aaatgaagt  tttaatcag  180
aaacattcc  ttttacctt  aaagtgctt  ttaaatgaa  gcaccaaca  gaactactt  240
cagatggta  agaatttct  atttcttga  gactctgtg  ttgaccact  cttcattag  300
tacctgcag  aagacacct  ccattttac  accaacacc  ctgaaggaa  caagaaaag  360
tttattaat  atcacttgg  ttgcctcag  tgttgaaat  aagcacttt  cagtctttg  420
ggcaccaga  tatacttgt  catggttca  atcaatgcc  tgggaagtg  gaaaaactc  480
atacgggtt  ctccaccat  accccaatt  ctccactcc  ccaggacat  gttcctcca  540
cataggtcc  cccagtccg  aacaacaaa  ttcaccctc  tgacccttg  aaaggtgcg  600
tcngccgct  ggccaatct  gcccaggca  atcccaaag  ggccataat  caacaggca  660
cgttccggg  aatgttccg  caatccaaa  atacgggca  agtaaccgg  gccaaagtg  720
accacaatg  g  731



<210> 4300
<211> 1436
<212> DNA
<213> Homo sapiens
<308> AK026373
<400> 4300

tgtgttgtc  gcaattcat  aggattaaa  tatgtagat  acttaaggg  tatctctgc  60
aggagaaac  cctttttag  tcttttaga  gctgcttct  caatgcaag  aaaggaaat  120
accccagcg  ggtactctt  agggacaca  gtctagtac  agagaactc  tgacggcta  180
taagttcag  cagtcttaa  aaactgtgc  gtttctaca  aactttaac  acagtagtt  240
ataaggatg  caacgaaag  tgagggtgt  gagcaaaat  gttctaagc  tcagttaaa  300
ttctttagg  aagatctta  ttacttttc  tttcttaat  ttcctccct  aaagataaa  360
taatactct  aaatggtct  tcagtatag  ggttcttac  tagtttaac  tagctataa  420
ttgagttta  caatttata  actcaagag  ataattttt  taaaccctg  ttttcaatc  480
gtcatttac  taaattatt  tggttgttt  tcccttttt  tccttcttt  cccaccccc  540
ccccctcca  gtgaagatt  gggtgctta  catatcatt  ttttccctg  cggaatttt  600
gcattgata  gaaccatgg  caagtatat  ctgctgcca  aaagactgt  aagtgcttc  660
tttcaacag  tgaggcaag  caagtgatc  ttaataaag  ttttcttgg  tccttcagt  720
gtgttggta  taaaatggt  ggtaaaagt  aggctgcaa  ttcaataaa  catgagatt  780
cccatcgtt  cacccttgt  tattcacat  tcttggatc  aacattttg  gtgaactag  840
ggtttttat  aaagacatt  gttgtattt  tggttgtaa  tgtacatgc  tatcaggat  900
agactgaaa  aaggtaggg  aaaaatggt  gaatctatt  tcagatagt  gttcatact  960
gagtgaagt  tcttgtctg  attatgaag  ctggtatgt  tccagtact  aataggtgg  1020
ttaaatgtg  taattctag  tcagtgtct  accctgaag  gaaggttgt  ggttggctg  1080
tgaaattca  tccttagat  tgatcagtt  gattgcccg  ctttattgc  tttacagga  1140
tgtgatact  agggcttac  ctatacacc  atgagtctt  tttgatcct  agaccacca  1200
tgaagttgt  taggttctt  tggacaaac  tgataaact  cttcagata  ttttttttt  1260
ctttggcag  aaggtgtct  gctgcaggt  actaatgaa  aagtggtca  ccacagagt  1320
ttcaagaaa  aagaaattc  gtaccatct  aaagtagtt  ttgttggtg  cttcattta  1380
aaagcactc  ttaaaataa  agggaaatg  tttctgata  aaaaaaaaa  aaaaaa  1436



<210> 4301
<211> 601
<212> DNA
<213> Rattus norvegicus
<308> AA799515
<400> 4301

aatgtactt  ttcaaataa  agaggggat  ctgtgcaca  tgcaatgtt  gcactgcct  60
cataaagca  caattaaga  aggcccaag  gtaggatgc  gtttctttt  aaataattt  120
aaatatatt  actttccta  ggcagattt  gtgtgaggc  tgttgaata  gtagctgct  180
ccgctgcca  agaacggtg  ttggaaggg  ctgtctgtt  tgggcagtt  gagttggag  240
gtaaatccc  tgaggtcaa  cagcagaga  aacgcacgt  acagcacaa  ccagtgatg  300
caacactga  tccacacgg  taagacttg  ctcacaact  ggccactta  gaaccctgg  360
tcttagaga  aattgagaa  acacagttg  accttagta  ctgctgaga  gacacatag  420
tatgatgct  atagtggcc  ttctggcgt  atgcatttg  ggaacacct  gtatgatct  480
atatactcg  ttgtccttg  ctatacatg  acaccactg  ttgaaagga  ataaaagcg  540
cttatgttg  tgaggagca  agccagttg  gtgcaccta  tacggagca  atacaagtg  600
t  601



<210> 4302
<211> 348
<212> DNA
<213> Rattus norvegicus
<308> AA799525
<400> 4302

gaccgaatc  tcggatatt  aatagagca  cctccttca  tacaaaacc  tggagagga  60
acaggtggc  tgggtggca  taatagttg  ctgtcttgg  aagcttggt  tcctcgatc  120
cagaagaca  ccagcggta  gtgcgatgt  gccggagca  ctcgatgga  ttgagctcc  180
gtggtgtgg  ctgaacgcc  agatcttcc  ggccgggca  gtcggtcgc  atcacatct  240
agatatgta  ccgctccac  ttgtccttt  ttgtccagg  ctcaaatgg  ctcagcccg  300
agagtctgc  aatccagct  tacacaagc  gtggcaagg  gtaaggga  348



<210> 4303
<211> 377
<212> PRT
<213> Rattus norvegicus
<308> NP_079634
<400> 4303

Met Ala Ala Ala Val Arg Phe Arg Val Val Arg Ala Leu Pro Met Ser 
  1               5                  10                  15
Arg Pro Ala Ile Thr Ala Ala Ala Thr Ser Val Phe Cys Gly Ser Ser 
             20                  25                  30
His Arg Gln Leu His His Ala Val Ile Pro His Gly Lys Gly Gly Arg 
         35                  40                  45
Ser Ser Val Ser Gly Val Val Ala Thr Val Phe Gly Ala Thr Gly Phe 
     50                  55                  60
Leu Gly Arg Tyr Val Val Asn His Leu Gly Arg Met Gly Ser Gln Val 
 65                  70                  75                  80
Ile Ile Pro Tyr Arg Cys Asp Val Tyr Asp Ile Met His Leu Arg Leu 
                 85                  90                  95
Met Gly Asp Pro Gly Gln Leu Thr Phe Leu Glu Trp Asp Ala Arg Asp 
             100                105                110
Lys Asp Ser Ile Arg Lys Ala Val Gln His Ser Asn Val Val Ile Asn 
         115                120                125
Leu Ile Gly Arg Glu Trp Glu Thr Arg Asn Phe Asp Phe Glu Asp Val 
     130                135                140
Phe Val Asn Ile Pro Arg Ala Ile Ala Gln Ala Ser Lys Glu Ala Gly 
 145                150                155                160
Val Glu Arg Phe Ile His Val Ser His Leu Asn Ala Ser Met Lys Ser 
                 165                170                175
Ser Ser Lys Ser Leu Arg Ser Lys Ala Val Gly Glu Lys Glu Val Arg 
             180                185                190
Ser Val Phe Pro Glu Ala Ile Ile Ile Arg Pro Ser Asp Ile Phe Gly 
         195                200                205
Arg Glu Asp Arg Phe Leu Asn His Phe Ala Asn Tyr Arg Trp Phe Leu 
     210                215                220
Ala Val Pro Leu Val Ser Leu Gly Phe Lys Thr Val Lys Gln Pro Val 
 225                230                235                240
Tyr Val Ala Asp Val Ser Lys Gly Ile Val Asn Ala Thr Lys Asp Pro 
                 245                250                255
Asp Ala Val Gly Lys Thr Phe Ala Phe Thr Gly Pro Asn Arg Tyr Leu 
             260                265                270
Leu Phe His Leu Val Lys Tyr Ile Phe Gly Met Thr His Arg Thr Phe 
         275                280                285
Ile Pro Tyr Pro Leu Pro Leu Phe Val Tyr Ser Trp Ile Gly Lys Leu 
     290                295                300
Phe Gly Leu Ser Pro Phe Glu Pro Trp Thr Thr Lys Asp Lys Val Glu 
 305                310                315                320
Arg Ile His Ile Ser Asp Val Met Pro Thr Asp Leu Pro Gly Leu Glu 
                 325                330                335
Asp Leu Gly Val Gln Pro Thr Pro Leu Glu Leu Lys Ser Ile Glu Val 
             340                345                350
Leu Arg Arg His Arg Thr Tyr Arg Trp Leu Ser Ser Glu Ile Glu Glu 
         355                360                365
Thr Lys Pro Ala Lys Thr Val Asn Tyr 
     370                375



<210> 4304
<211> 1507
<212> DNA
<213> Homo sapiens
<308> L04490
<400> 4304

ggctgccgc  caatcccgg  ttgtccggg  cctgtcaat  tcacgttct  ccattactg  60
aatagccac  tctgtgtgt  acggcccac  ctgtcgcca  cttcatcat  ccctcatgc  120
tcatgggaa  ggtggacgt  cctcagtca  tgggattgt  gccactgtg  ttggagcaa  180
aggattcct  gggcgatat  ttgtcaacc  ccttggacg  atggggtca  aggtaatca  240
accctatcg  tgtgataaa  atgacatca  gcaccttcg  cccatgggt  acctgggcc  300
gcttctgtt  ctggaatgg  acgcgagag  taaagattc  atccgacga  tagtacaac  360
cagcaatgt  gtcatcaat  ttattggac  agactggga  accaaaaac  ttgattttg  420
ggatgtttt  gtgaagatt  cccaagcaa  tgctcaact  tccaaggaa  ctggagttg  480
aaaattcat  catgtttca  atctgaatg  gaatattaa  agctcttct  gatatttga  540
aaataaggc  gttggagag  aagtagtga  agatgcatt  ccggaagcc  ttatcgtaa  600
gccgtcgga  atctttgga  gagaggata  attccttaa  tcttttgca  gtatgcatc  660
gtttggtcc  atacccctt  gttccttgg  ctggaagac  gttaaacaa  cagtatatg  720
cgtagatgt  tccaaagga  ttgttaatg  agttaagga  cctgatgcc  atgggaaat  780
ctttgcttt  gttggtccc  gtcggtacc  ccttttcca  ctggtgaag  acatctttg  840
tgtggctca  agattgttc  tcccattcc  cttgccgct  tttgcctat  gatgggtag  900
aagagtctt  gaaataagc  catttgagc  ctggataac  agggataaa  tggagcgga  960
gcacatcac  gacatgaaa  tgcctcacc  gcctggctt  gaagacctt  gtattcagg  1020
aacaccact  gaactcaag  ccattgagg  gctgcggcg  catcgcact  accgctggc  1080
gtctgctga  attgaggat  tgaagccgg  caagaccgt  aacatttag  gcctcctga  1140
cagctcttg  ttttggcgt  ttttgggtc  gcccatgtg  tttgagcac  cagccaggc  1200
gtctcttta  aggatcctg  acacagttc  actattaaa  catttcagg  tgaattctg  1260
agtattttc  tccttgatt  acaaaatga  aaatgtagt  acttagaac  tgagcatga  1320
ttttgttaa  catatttaa  aatgatata  atactattt  ttctctgaa  tgccagaga  1380
tttgaattt  cctatgaca  accacttct  gcatacgtt  tagaagaca  ggacccttt  1440
taatgtcaa  gtattgtaa  gaccccaag  gatatgtga  tgtttttta  tttccatta  1500
atgagag  1507



<210> 4305
<211> 377
<212> PRT
<213> Homo sapiens
<308> Q16795
<400> 4305

Met Ala Ala Ala Ala Gln Ser Arg Val Val Arg Val Leu Ser Met Ser 
  1               5                  10                  15
Arg Ser Ala Ile Thr Ala Ile Ala Thr Ser Val Cys His Gly Pro Pro 
             20                  25                  30
Cys Arg Gln Leu His His Ala Leu Met Pro His Gly Lys Gly Gly Arg 
         35                  40                  45
Ser Ser Val Ser Gly Ile Val Ala Thr Val Phe Gly Ala Thr Gly Phe 
     50                  55                  60
Leu Gly Arg Tyr Val Val Asn His Leu Gly Arg Met Gly Ser Gln Val 
 65                  70                  75                  80
Ile Ile Pro Tyr Arg Cys Asp Lys Tyr Asp Ile Met His Leu Arg Pro 
                 85                  90                  95
Met Gly Asp Leu Gly Gln Leu Leu Phe Leu Glu Trp Asp Ala Arg Asp 
             100                105                110
Lys Asp Ser Ile Arg Arg Val Val Gln His Ser Asn Val Val Ile Asn 
         115                120                125
Leu Ile Gly Arg Asp Trp Glu Thr Lys Asn Phe Asp Phe Glu Asp Val 
     130                135                140
Phe Val Lys Ile Pro Gln Ala Ile Ala Gln Leu Ser Lys Glu Ala Gly 
 145                150                155                160
Val Glu Lys Phe Ile His Val Ser His Leu Asn Ala Asn Ile Lys Ser 
                 165                170                175
Ser Ser Arg Tyr Leu Arg Asn Lys Ala Val Gly Glu Lys Val Val Arg 
             180                185                190
Asp Ala Phe Pro Glu Ala Ile Ile Val Lys Pro Ser Asp Ile Phe Gly 
         195                200                205
Arg Glu Asp Arg Phe Leu Asn Ser Phe Ala Ser Met His Arg Phe Gly 
     210                215                220
Pro Ile Pro Leu Gly Ser Leu Gly Trp Lys Thr Val Lys Gln Pro Val 
 225                230                235                240
Tyr Val Val Asp Val Ser Lys Gly Ile Val Asn Ala Val Lys Asp Pro 
                 245                250                255
Asp Ala Asn Gly Lys Ser Phe Ala Phe Val Gly Pro Ser Arg Tyr Leu 
             260                265                270
Leu Phe His Leu Val Lys Tyr Ile Phe Ala Val Ala His Arg Leu Phe 
         275                280                285
Leu Pro Phe Pro Leu Pro Leu Phe Ala Tyr Arg Trp Val Ala Arg Val 
     290                295                300
Phe Glu Ile Ser Pro Phe Glu Pro Trp Ile Thr Arg Asp Lys Val Glu 
 305                310                315                320
Arg Met His Ile Thr Asp Met Lys Leu Pro His Leu Pro Gly Leu Glu 
                 325                330                335
Asp Leu Gly Ile Gln Ala Thr Pro Leu Glu Leu Lys Ala Ile Glu Val 
             340                345                350
Leu Arg Arg His Arg Thr Tyr Arg Trp Leu Ser Ala Glu Ile Glu Asp 
         355                360                365
Val Lys Pro Ala Lys Thr Val Asn Ile 
     370                375



<210> 4306
<211> 570
<212> DNA
<213> Rattus norvegicus
<308> AA799531
<400> 4306

aaggcggca  ctgtttatt  tgaggtaac  gtcacacag  actgttata  ggtagaata  60
tcattatgt  atcttgaga  aggttgtct  aggtaggat  tggagcctt  cacacttat  120
agatgcctt  tcattagtt  cttctagtt  tgcaattct  gatccaaat  gtatggccc  180
tttgggcag  agggcagag  atgagagac  aagttccac  gctgcaagg  gtaaaatga  240
cttctcacc  actccacgg  gcaaagcca  gtctacctt  tcccaaact  gcagagaat  300
caggaaaga  acaacattt  catccagaa  aggaaatct  gcttccttt  catgatcag  360
aataactct  tcatcacga  caaggtttc  agaagaaat  cgacccaat  ccattgcta  420
ttcctcatt  aatccttct  ggccaagag  ctgaaagcg  gcacgatga  gggaataac  480
tgccaactg  tcatctgcn  caatcccag  gagaatcac  tttgcactg  tcttgntag  540
ctgcacagc  tcctcggtt  acaacaaaac  570



<210> 4307
<211> 627
<212> PRT
<213> Rattus norvegicus
<308> AAH13617
<400> 4307

Met Cys Gly Ile Cys Cys Ser Val Ser Phe Ser Ile Glu His Phe Ser 
  1               5                  10                  15
Lys Glu Leu Lys Glu Asp Leu Leu His Asn Leu Arg Arg Arg Gly Pro 
             20                  25                  30
Asn Ser Ser Arg Gln Leu Leu Lys Ser Ala Val Asn Tyr Gln Cys Leu 
         35                  40                  45
Phe Ser Gly His Val Leu His Leu Arg Gly Val Leu Thr Ile Gln Pro 
     50                  55                  60
Val Glu Asp Glu His Gly Asn Val Phe Leu Trp Asn Gly Glu Val Phe 
 65                  70                  75                  80
Asn Gly Val Lys Val Glu Ala Glu Asp Asn Asp Thr Gln Val Met Phe 
                 85                  90                  95
Asn Ser Leu Ser Ala Cys Lys Asn Glu Ser Glu Ile Leu Leu Leu Phe 
             100                105                110
Ser Lys Val Gln Gly Pro Trp Ser Phe Ile Tyr Tyr Gln Ala Ser Ser 
         115                120                125
His His Leu Trp Phe Gly Arg Asp Phe Phe Gly Arg Arg Ser Leu Leu 
     130                135                140
Trp Gln Phe Ser Asn Leu Gly Lys Ser Phe Cys Leu Ser Ser Val Gly 
 145                150                155                160
Thr Gln Val Tyr Gly Val Ala Asp Gln Trp Gln Glu Val Pro Ala Ser 
                 165                170                175
Gly Ile Phe Gln Ile Asp Leu Asn Ser Ala Ala Val Ser Arg Ser Val 
             180                185                190
Ile Leu Lys Leu Tyr Pro Trp Arg Tyr Ile Ser Lys Glu Asp Ile Ala 
         195                200                205
Glu Glu Cys Gly Asn Asp Leu Thr Gln Thr Pro Ala Gly Leu Pro Glu 
     210                215                220
Phe Val Ser Val Val Ile Asn Glu Ala Asn Leu Tyr Leu Ser Lys Pro 
 225                230                235                240
Val Val Pro Leu Asn Lys Lys Leu Pro Glu Ser Pro Leu Glu Ile Gln 
                 245                250                255
Cys Arg Asn Ser Ser Ser Thr Ser Gly Thr Arg Glu Thr Leu Glu Val 
             260                265                270
Phe Leu Thr Asp Glu His Thr Lys Lys Ile Val Gln Gln Phe Ile Ala 
         275                280                285
Ile Leu Asn Val Ser Val Lys Arg Arg Ile Leu Cys Leu Ala Arg Glu 
     290                295                300
Glu Asn Leu Ala Ser Lys Glu Val Leu Lys Thr Cys Ser Ser Lys Ala 
 305                310                315                320
Asn Ile Ala Ile Leu Phe Ser Gly Gly Val Asp Ser Met Val Ile Ala 
                 325                330                335
Ala Leu Ala Asp Arg His Ile Pro Leu Asp Glu Pro Ile Asp Leu Leu 
             340                345                350
Asn Val Ala Phe Val Pro Lys Gln Lys Thr Gly Leu Pro Ile Pro Asn 
         355                360                365
Ile Glu Arg Lys Gln Gln Asn His His Glu Ile Pro Ser Glu Glu Ser 
     370                375                380
Ser Gln Ser Pro Ala Ala Asp Glu Gly Pro Gly Glu Ala Glu Val Pro 
 385                390                395                400
Asp Arg Val Thr Gly Lys Ala Gly Leu Lys Glu Leu Gln Ser Val Asn 
                 405                410                415
Pro Ser Arg Thr Trp Asn Phe Val Glu Ile Asn Val Ser Leu Glu Glu 
             420                425                430
Leu Gln Lys Leu Arg Arg Ala Arg Ile Cys His Leu Val Gln Pro Leu 
         435                440                445
Asp Thr Val Leu Asp Asp Ser Ile Gly Cys Ala Val Trp Phe Ala Ser 
     450                455                460
Arg Gly Ile Gly Trp Leu Val Thr Gln Asp Ala Val Arg Ser Tyr Lys 
 465                470                475                480
Ser Ser Ala Lys Val Ile Leu Thr Gly Ile Gly Ala Asp Glu Gln Leu 
                 485                490                495
Ala Gly Tyr Ser Arg His Arg Ala Arg Phe Gln Ser Leu Gly Leu Glu 
             500                505                510
Gly Leu Asn Glu Glu Ile Ala Met Glu Leu Gly Arg Ile Ser Ser Arg 
         515                520                525
Asn Leu Gly Arg Asp Asp Arg Val Ile Gly Asp His Gly Lys Glu Ala 
     530                535                540
Arg Phe Pro Phe Leu Asp Glu Asn Val Val Ser Phe Leu Asn Ser Leu 
 545                550                555                560
Pro Val Trp Glu Lys Val Asp Leu Thr Leu Pro Arg Gly Val Gly Glu 
                 565                570                575
Lys Leu Ile Leu Arg Leu Ala Ala Met Glu Leu Gly Leu Pro Ala Ser 
             580                585                590
Ala Leu Leu Pro Lys Arg Ala Ile Gln Phe Gly Ser Arg Ile Ala Lys 
         595                600                605
Leu Glu Lys Phe Asn Glu Lys Ala Ser Asp Lys Cys Gly Arg Leu Gln 
     610                615                620
Ile Leu Pro 
 625



<210> 4308
<211> 2448
<212> DNA
<213> Homo sapiens
<308> AK000759
<400> 4308

aaaagaaag  gtgagcgcg  ctggaagcg  gcatgcgct  tggctaatg  cgtaggctc  60
ttcagggct  agccatccc  cgtgtcttg  gctcggtgg  aatgcccag  cgagggacg  120
gaccagagg  cagctctgt  ctgatcccc  ccgacaatt  gaccccaca  aaggaggat  180
taagcagca  gattaaaga  caaaaaatt  tggtggatg  actttctaa  cttaagaag  240
ataggaaag  atataggca  caacagaac  gcaatatat  ctttcttgc  gaccgaaca  300
aaatgctgt  tgagagcaa  aatatattg  atgaactga  aaaagaata  caagaaata  360
aaaacttag  caagaccaa  atcaagaaa  agtcaacct  atttcacat  acaatgtgt  420
gcatttgtt  ttctgtaaa  ttttctgct  agcatttca  tcaagattt  aaagaggac  480
tactatata  tcttaaaca  cggggaccc  atagtagta  acaattgtt  aagtctgat  540
ttaactacc  gtgtttatt  tctgctcac  tcctacact  gaggggtgt  ttgactacc  600
agcctgtgg  agatgaaag  ggcaatgtg  ttctatgga  tggagaaat  tttagtgga  660
taaaggttg  agctgaaga  aatgacact  aaattttgt  taattatct  tcctcctgt  720
agaatgaat  tgagatttt  tcactcttc  cagaagtac  aggtccctg  tcatttata  780
attatcaag  atctagtca  tatttatgg  ttggtaggg  tttttttgg  cgccgtagc  840
tgctttggc  ttttagtaa  ttgggcaag  gtttctgcc  ctcttcagt  ggcacccaa  900
catctggat  ggcaaatca  tggcaagaa  ttccagcat  tggactttt  agaattgat  960
ttaagtcta  tgtcatttc  agatgcatt  ttttacaac  gtatccttg  aaatatatt  1020
ctagggaga  tattattga  gaaaatgtt  atagcctga  tcaaatttc  gcagactta  1080
cagcatttg  atcagtggt  gcaaatgaa  ccaaactgt  tcttgaaaa  cctgttgtt  1140
ctttaaata  gatgttgcc  caagctgca  tggagactc  ttgcagtaa  atttccaat  1200
tgccaccta  aagagagat  cttcaagtc  ttcttactg  tgtacacat  aaggaagta  1260
ttcagcagt  cattgatgt  ctgagtgta  cagtcaaga  acgtgtctt  tgtttacct  1320
gggatgaaa  cctgacagc  aatgaagtt  tgaaaacgt  tgataggaa  gcaaatgtt  1380
caatcctgt  ttctggggg  attgattcc  tggttattg  aacccttgc  gaccgtcat  1440
ttcctttag  tgaaccaat  gatcttctt  atgtagctt  catagctga  gaaaagacc  1500
tgccaacta  ctttaacag  gaagggaat  aacagaaaa  taaatgtga  ataccttca  1560
aagaattct  taaagatgt  gctgctgct  ctgctgaca  tcctaataa  catgtcagt  1620
taccagatc  aatcacagg  agggcggga  taaaggaac  acaagctgt  agcccttcc  1680
gaatttgga  ttttgttga  attaatgtt  ctatggaag  actgcagaa  ttaagaaga  1740
ctcgaatat  tcacttaat  cggccattg  atacagttt  ggatgatag  attggctgt  1800
cagtctggt  tgcttctag  ggaattggt  ggttagtgg  ccaggaagg  gtgaaatcc  1860
atcagagca  tgcaaaggt  gttctcact  gaattggtg  agatgagca  cttgcaggt  1920
attctcgtc  tcgtgtccg  tttcagtcg  atgggctgg  aggattgaa  aaggaaata  1980
tgatggaac  gggtcgaat  tcttctaga  atcttggtc  tgatgacag  gttattggt  2040
atcatggaa  agaagcaag  tttcctttc  tggatgaaa  tgttgtctc  tttctaaat  2100
ctctgccga  ttgggaaaa  gcaaacttg  ctttacccc  aggaattgg  gaaaaatta  2160
ttttacgcc  tgcagctgt  gaacttggt  ttacagcct  tgctcttct  cccaaacgg  2220
ccatgcagt  tggatcaag  attgcaaaa  tggaaaaaa  taatgaaaa  gcatctgat  2280
aatgtggac  gctccaaat  atgtcctta  aaaatcttt  tattgaaaa  gagactaaa  2340
tgtaatgtg  ttcacaatg  aacaatata  aaataagtt  ttatataat  atataaaag  2400
aaggtactc  gctgcttta  tattgtata  tatagtagt  ttaaagtt  2448



<210> 4309
<211> 644
<212> PRT
<213> Homo sapiens
<308> AK000759
<400> 4309

Met Cys Gly Ile Cys Cys Ser Val Asn Phe Ser Ala Glu His Phe Ser 
  1               5                  10                  15
Gln Asp Leu Lys Glu Asp Leu Leu Tyr Asn Leu Lys Gln Arg Gly Pro 
             20                  25                  30
Asn Ser Ser Lys Gln Leu Leu Lys Ser Asp Val Asn Tyr Gln Cys Leu 
         35                  40                  45
Phe Ser Ala His Val Leu His Leu Arg Gly Val Leu Thr Thr Gln Pro 
     50                  55                  60
Val Glu Asp Glu Arg Gly Asn Val Phe Leu Trp Asn Gly Glu Ile Phe 
 65                  70                  75                  80
Ser Gly Ile Lys Val Glu Ala Glu Glu Asn Asp Thr Gln Ile Leu Phe 
                 85                  90                  95
Asn Tyr Leu Ser Ser Cys Lys Asn Glu Ser Glu Ile Leu Ser Leu Phe 
             100                105                110
Ser Glu Val Gln Gly Pro Trp Ser Phe Ile Tyr Tyr Gln Ala Ser Ser 
         115                120                125
His Tyr Leu Trp Phe Gly Arg Asp Phe Phe Gly Arg Arg Ser Leu Leu 
     130                135                140
Trp His Phe Ser Asn Leu Gly Lys Ser Phe Cys Leu Ser Ser Val Gly 
 145                150                155                160
Thr Gln Thr Ser Gly Leu Ala Asn Gln Trp Gln Glu Val Pro Ala Ser 
                 165                170                175
Gly Leu Phe Arg Ile Asp Leu Lys Ser Thr Val Ile Ser Arg Cys Ile 
             180                185                190
Ile Leu Gln Leu Tyr Pro Trp Lys Tyr Ile Ser Arg Glu Asn Ile Ile 
         195                200                205
Glu Glu Asn Val Asn Ser Leu Ser Gln Ile Ser Ala Asp Leu Pro Ala 
     210                215                220
Phe Val Ser Val Val Ala Asn Glu Ala Lys Leu Tyr Leu Glu Lys Pro 
 225                230                235                240
Val Val Pro Leu Asn Met Met Leu Pro Gln Ala Ala Leu Glu Thr His 
                 245                250                255
Cys Ser Asn Ile Ser Asn Val Pro Pro Thr Arg Glu Ile Leu Gln Val 
             260                265                270
Phe Leu Thr Asp Val His Met Lys Glu Val Ile Gln Gln Phe Ile Asp 
         275                280                285
Val Leu Ser Val Ala Val Lys Lys Arg Val Leu Cys Leu Pro Arg Asp 
     290                295                300
Glu Asn Leu Thr Ala Asn Glu Val Leu Lys Thr Cys Asp Arg Lys Ala 
 305                310                315                320
Asn Val Ala Ile Leu Phe Ser Gly Gly Ile Asp Ser Met Val Ile Ala 
                 325                330                335
Thr Leu Ala Asp Arg His Ile Pro Leu Asp Glu Pro Ile Asp Leu Leu 
             340                345                350
Asn Val Ala Phe Ile Ala Glu Glu Lys Thr Met Pro Thr Thr Phe Asn 
         355                360                365
Arg Glu Gly Asn Lys Gln Lys Asn Lys Cys Glu Ile Pro Ser Glu Glu 
     370                375                380
Phe Ser Lys Asp Val Ala Ala Ala Ala Ala Asp Ser Pro Asn Lys His 
 385                390                395                400
Val Ser Val Pro Asp Arg Ile Thr Gly Arg Ala Gly Leu Lys Glu Leu 
                 405                410                415
Gln Ala Val Ser Pro Ser Arg Ile Trp Asn Phe Val Glu Ile Asn Val 
             420                425                430
Ser Met Glu Glu Leu Gln Lys Leu Arg Arg Thr Arg Ile Cys His Leu 
         435                440                445
Ile Arg Pro Leu Asp Thr Val Leu Asp Asp Ser Ile Gly Cys Ala Val 
     450                455                460
Trp Phe Ala Ser Arg Gly Ile Gly Trp Leu Val Ala Gln Glu Gly Val 
 465                470                475                480
Lys Ser Tyr Gln Ser Asn Ala Lys Val Val Leu Thr Gly Ile Gly Ala 
                 485                490                495
Asp Glu Gln Leu Ala Gly Tyr Ser Arg His Arg Val Arg Phe Gln Ser 
             500                505                510
His Gly Leu Glu Gly Leu Asn Lys Glu Ile Met Met Glu Leu Gly Arg 
         515                520                525
Ile Ser Ser Arg Asn Leu Gly Arg Asp Asp Arg Val Ile Gly Asp His 
     530                535                540
Gly Lys Glu Ala Arg Phe Pro Phe Leu Asp Glu Asn Val Val Ser Phe 
 545                550                555                560
Leu Asn Ser Leu Pro Ile Trp Glu Lys Ala Asn Leu Thr Leu Pro Arg 
                 565                570                575
Gly Ile Gly Glu Lys Leu Leu Leu Arg Leu Ala Ala Val Glu Leu Gly 
             580                585                590
Leu Thr Ala Ser Ala Leu Leu Pro Lys Arg Ala Met Gln Phe Gly Ser 
         595                600                605
Arg Ile Ala Lys Met Glu Lys Ile Asn Glu Lys Ala Ser Asp Lys Cys 
     610                615                620
Gly Arg Leu Gln Ile Met Ser Leu Glu Asn Leu Ser Ile Glu Lys Glu 
 625                630                635                640
Thr Lys Leu Ter 
                 645



<210> 4310
<211> 570
<212> DNA
<213> Rattus norvegicus
<308> AA799531
<400> 4310

aaggcggca  ctgtttatt  tgaggtaac  gtcacacag  actgttata  ggtagaata  60
tcattatgt  atcttgaga  aggttgtct  aggtaggat  tggagcctt  cacacttat  120
agatgcctt  tcattagtt  cttctagtt  tgcaattct  gatccaaat  gtatggccc  180
tttgggcag  agggcagag  atgagagac  aagttccac  gctgcaagg  gtaaaatga  240
cttctcacc  actccacgg  gcaaagcca  gtctacctt  tcccaaact  gcagagaat  300
caggaaaga  acaacattt  catccagaa  aggaaatct  gcttccttt  catgatcag  360
aataactct  tcatcacga  caaggtttc  agaagaaat  cgacccaat  ccattgcta  420
ttcctcatt  aatccttct  ggccaagag  ctgaaagcg  gcacgatga  gggaataac  480
tgccaactg  tcatctgcn  caatcccag  gagaatcac  tttgcactg  tcttgntag  540
ctgcacagc  tcctcggtt  acaacaaaac  570



<210> 4311
<211> 627
<212> PRT
<213> Rattus norvegicus
<308> AAH13617
<400> 4311

Met Cys Gly Ile Cys Cys Ser Val Ser Phe Ser Ile Glu His Phe Ser 
  1               5                  10                  15
Lys Glu Leu Lys Glu Asp Leu Leu His Asn Leu Arg Arg Arg Gly Pro 
             20                  25                  30
Asn Ser Ser Arg Gln Leu Leu Lys Ser Ala Val Asn Tyr Gln Cys Leu 
         35                  40                  45
Phe Ser Gly His Val Leu His Leu Arg Gly Val Leu Thr Ile Gln Pro 
     50                  55                  60
Val Glu Asp Glu His Gly Asn Val Phe Leu Trp Asn Gly Glu Val Phe 
 65                  70                  75                  80
Asn Gly Val Lys Val Glu Ala Glu Asp Asn Asp Thr Gln Val Met Phe 
                 85                  90                  95
Asn Ser Leu Ser Ala Cys Lys Asn Glu Ser Glu Ile Leu Leu Leu Phe 
             100                105                110
Ser Lys Val Gln Gly Pro Trp Ser Phe Ile Tyr Tyr Gln Ala Ser Ser 
         115                120                125
His His Leu Trp Phe Gly Arg Asp Phe Phe Gly Arg Arg Ser Leu Leu 
     130                135                140
Trp Gln Phe Ser Asn Leu Gly Lys Ser Phe Cys Leu Ser Ser Val Gly 
 145                150                155                160
Thr Gln Val Tyr Gly Val Ala Asp Gln Trp Gln Glu Val Pro Ala Ser 
                 165                170                175
Gly Ile Phe Gln Ile Asp Leu Asn Ser Ala Ala Val Ser Arg Ser Val 
             180                185                190
Ile Leu Lys Leu Tyr Pro Trp Arg Tyr Ile Ser Lys Glu Asp Ile Ala 
         195                200                205
Glu Glu Cys Gly Asn Asp Leu Thr Gln Thr Pro Ala Gly Leu Pro Glu 
     210                215                220
Phe Val Ser Val Val Ile Asn Glu Ala Asn Leu Tyr Leu Ser Lys Pro 
 225                230                235                240
Val Val Pro Leu Asn Lys Lys Leu Pro Glu Ser Pro Leu Glu Ile Gln 
                 245                250                255
Cys Arg Asn Ser Ser Ser Thr Ser Gly Thr Arg Glu Thr Leu Glu Val 
             260                265                270
Phe Leu Thr Asp Glu His Thr Lys Lys Ile Val Gln Gln Phe Ile Ala 
         275                280                285
Ile Leu Asn Val Ser Val Lys Arg Arg Ile Leu Cys Leu Ala Arg Glu 
     290                295                300
Glu Asn Leu Ala Ser Lys Glu Val Leu Lys Thr Cys Ser Ser Lys Ala 
 305                310                315                320
Asn Ile Ala Ile Leu Phe Ser Gly Gly Val Asp Ser Met Val Ile Ala 
                 325                330                335
Ala Leu Ala Asp Arg His Ile Pro Leu Asp Glu Pro Ile Asp Leu Leu 
             340                345                350
Asn Val Ala Phe Val Pro Lys Gln Lys Thr Gly Leu Pro Ile Pro Asn 
         355                360                365
Ile Glu Arg Lys Gln Gln Asn His His Glu Ile Pro Ser Glu Glu Ser 
     370                375                380
Ser Gln Ser Pro Ala Ala Asp Glu Gly Pro Gly Glu Ala Glu Val Pro 
 385                390                395                400
Asp Arg Val Thr Gly Lys Ala Gly Leu Lys Glu Leu Gln Ser Val Asn 
                 405                410                415
Pro Ser Arg Thr Trp Asn Phe Val Glu Ile Asn Val Ser Leu Glu Glu 
             420                425                430
Leu Gln Lys Leu Arg Arg Ala Arg Ile Cys His Leu Val Gln Pro Leu 
         435                440                445
Asp Thr Val Leu Asp Asp Ser Ile Gly Cys Ala Val Trp Phe Ala Ser 
     450                455                460
Arg Gly Ile Gly Trp Leu Val Thr Gln Asp Ala Val Arg Ser Tyr Lys 
 465                470                475                480
Ser Ser Ala Lys Val Ile Leu Thr Gly Ile Gly Ala Asp Glu Gln Leu 
                 485                490                495
Ala Gly Tyr Ser Arg His Arg Ala Arg Phe Gln Ser Leu Gly Leu Glu 
             500                505                510
Gly Leu Asn Glu Glu Ile Ala Met Glu Leu Gly Arg Ile Ser Ser Arg 
         515                520                525
Asn Leu Gly Arg Asp Asp Arg Val Ile Gly Asp His Gly Lys Glu Ala 
     530                535                540
Arg Phe Pro Phe Leu Asp Glu Asn Val Val Ser Phe Leu Asn Ser Leu 
 545                550                555                560
Pro Val Trp Glu Lys Val Asp Leu Thr Leu Pro Arg Gly Val Gly Glu 
                 565                570                575
Lys Leu Ile Leu Arg Leu Ala Ala Met Glu Leu Gly Leu Pro Ala Ser 
             580                585                590
Ala Leu Leu Pro Lys Arg Ala Ile Gln Phe Gly Ser Arg Ile Ala Lys 
         595                600                605
Leu Glu Lys Phe Asn Glu Lys Ala Ser Asp Lys Cys Gly Arg Leu Gln 
     610                615                620
Ile Leu Pro 
 625



<210> 4312
<211> 2448
<212> DNA
<213> Homo sapiens
<308> AK000759
<400> 4312

aaaagaaag  gtgagcgcg  ctggaagcg  gcatgcgct  tggctaatg  cgtaggctc  60
ttcagggct  agccatccc  cgtgtcttg  gctcggtgg  aatgcccag  cgagggacg  120
gaccagagg  cagctctgt  ctgatcccc  ccgacaatt  gaccccaca  aaggaggat  180
taagcagca  gattaaaga  caaaaaatt  tggtggatg  actttctaa  cttaagaag  240
ataggaaag  atataggca  caacagaac  gcaatatat  ctttcttgc  gaccgaaca  300
aaatgctgt  tgagagcaa  aatatattg  atgaactga  aaaagaata  caagaaata  360
aaaacttag  caagaccaa  atcaagaaa  agtcaacct  atttcacat  acaatgtgt  420
gcatttgtt  ttctgtaaa  ttttctgct  agcatttca  tcaagattt  aaagaggac  480
tactatata  tcttaaaca  cggggaccc  atagtagta  acaattgtt  aagtctgat  540
ttaactacc  gtgtttatt  tctgctcac  tcctacact  gaggggtgt  ttgactacc  600
agcctgtgg  agatgaaag  ggcaatgtg  ttctatgga  tggagaaat  tttagtgga  660
taaaggttg  agctgaaga  aatgacact  aaattttgt  taattatct  tcctcctgt  720
agaatgaat  tgagatttt  tcactcttc  cagaagtac  aggtccctg  tcatttata  780
attatcaag  atctagtca  tatttatgg  ttggtaggg  tttttttgg  cgccgtagc  840
tgctttggc  ttttagtaa  ttgggcaag  gtttctgcc  ctcttcagt  ggcacccaa  900
catctggat  ggcaaatca  tggcaagaa  ttccagcat  tggactttt  agaattgat  960
ttaagtcta  tgtcatttc  agatgcatt  ttttacaac  gtatccttg  aaatatatt  1020
ctagggaga  tattattga  gaaaatgtt  atagcctga  tcaaatttc  gcagactta  1080
cagcatttg  atcagtggt  gcaaatgaa  ccaaactgt  tcttgaaaa  cctgttgtt  1140
ctttaaata  gatgttgcc  caagctgca  tggagactc  ttgcagtaa  atttccaat  1200
tgccaccta  aagagagat  cttcaagtc  ttcttactg  tgtacacat  aaggaagta  1260
ttcagcagt  cattgatgt  ctgagtgta  cagtcaaga  acgtgtctt  tgtttacct  1320
gggatgaaa  cctgacagc  aatgaagtt  tgaaaacgt  tgataggaa  gcaaatgtt  1380
caatcctgt  ttctggggg  attgattcc  tggttattg  aacccttgc  gaccgtcat  1440
ttcctttag  tgaaccaat  gatcttctt  atgtagctt  catagctga  gaaaagacc  1500
tgccaacta  ctttaacag  gaagggaat  aacagaaaa  taaatgtga  ataccttca  1560
aagaattct  taaagatgt  gctgctgct  ctgctgaca  tcctaataa  catgtcagt  1620
taccagatc  aatcacagg  agggcggga  taaaggaac  acaagctgt  agcccttcc  1680
gaatttgga  ttttgttga  attaatgtt  ctatggaag  actgcagaa  ttaagaaga  1740
ctcgaatat  tcacttaat  cggccattg  atacagttt  ggatgatag  attggctgt  1800
cagtctggt  tgcttctag  ggaattggt  ggttagtgg  ccaggaagg  gtgaaatcc  1860
atcagagca  tgcaaaggt  gttctcact  gaattggtg  agatgagca  cttgcaggt  1920
attctcgtc  tcgtgtccg  tttcagtcg  atgggctgg  aggattgaa  aaggaaata  1980
tgatggaac  gggtcgaat  tcttctaga  atcttggtc  tgatgacag  gttattggt  2040
atcatggaa  agaagcaag  tttcctttc  tggatgaaa  tgttgtctc  tttctaaat  2100
ctctgccga  ttgggaaaa  gcaaacttg  ctttacccc  aggaattgg  gaaaaatta  2160
ttttacgcc  tgcagctgt  gaacttggt  ttacagcct  tgctcttct  cccaaacgg  2220
ccatgcagt  tggatcaag  attgcaaaa  tggaaaaaa  taatgaaaa  gcatctgat  2280
aatgtggac  gctccaaat  atgtcctta  aaaatcttt  tattgaaaa  gagactaaa  2340
tgtaatgtg  ttcacaatg  aacaatata  aaataagtt  ttatataat  atataaaag  2400
aaggtactc  gctgcttta  tattgtata  tatagtagt  ttaaagtt  2448



<210> 4313
<211> 644
<212> PRT
<213> Homo sapiens
<308> AK000759
<400> 4313

Met Cys Gly Ile Cys Cys Ser Val Asn Phe Ser Ala Glu His Phe Ser 
  1               5                  10                  15
Gln Asp Leu Lys Glu Asp Leu Leu Tyr Asn Leu Lys Gln Arg Gly Pro 
             20                  25                  30
Asn Ser Ser Lys Gln Leu Leu Lys Ser Asp Val Asn Tyr Gln Cys Leu 
         35                  40                  45
Phe Ser Ala His Val Leu His Leu Arg Gly Val Leu Thr Thr Gln Pro 
     50                  55                  60
Val Glu Asp Glu Arg Gly Asn Val Phe Leu Trp Asn Gly Glu Ile Phe 
 65                  70                  75                  80
Ser Gly Ile Lys Val Glu Ala Glu Glu Asn Asp Thr Gln Ile Leu Phe 
                 85                  90                  95
Asn Tyr Leu Ser Ser Cys Lys Asn Glu Ser Glu Ile Leu Ser Leu Phe 
             100                105                110
Ser Glu Val Gln Gly Pro Trp Ser Phe Ile Tyr Tyr Gln Ala Ser Ser 
         115                120                125
His Tyr Leu Trp Phe Gly Arg Asp Phe Phe Gly Arg Arg Ser Leu Leu 
     130                135                140
Trp His Phe Ser Asn Leu Gly Lys Ser Phe Cys Leu Ser Ser Val Gly 
 145                150                155                160
Thr Gln Thr Ser Gly Leu Ala Asn Gln Trp Gln Glu Val Pro Ala Ser 
                 165                170                175
Gly Leu Phe Arg Ile Asp Leu Lys Ser Thr Val Ile Ser Arg Cys Ile 
             180                185                190
Ile Leu Gln Leu Tyr Pro Trp Lys Tyr Ile Ser Arg Glu Asn Ile Ile 
         195                200                205
Glu Glu Asn Val Asn Ser Leu Ser Gln Ile Ser Ala Asp Leu Pro Ala 
     210                215                220
Phe Val Ser Val Val Ala Asn Glu Ala Lys Leu Tyr Leu Glu Lys Pro 
 225                230                235                240
Val Val Pro Leu Asn Met Met Leu Pro Gln Ala Ala Leu Glu Thr His 
                 245                250                255
Cys Ser Asn Ile Ser Asn Val Pro Pro Thr Arg Glu Ile Leu Gln Val 
             260                265                270
Phe Leu Thr Asp Val His Met Lys Glu Val Ile Gln Gln Phe Ile Asp 
         275                280                285
Val Leu Ser Val Ala Val Lys Lys Arg Val Leu Cys Leu Pro Arg Asp 
     290                295                300
Glu Asn Leu Thr Ala Asn Glu Val Leu Lys Thr Cys Asp Arg Lys Ala 
 305                310                315                320
Asn Val Ala Ile Leu Phe Ser Gly Gly Ile Asp Ser Met Val Ile Ala 
                 325                330                335
Thr Leu Ala Asp Arg His Ile Pro Leu Asp Glu Pro Ile Asp Leu Leu 
             340                345                350
Asn Val Ala Phe Ile Ala Glu Glu Lys Thr Met Pro Thr Thr Phe Asn 
         355                360                365
Arg Glu Gly Asn Lys Gln Lys Asn Lys Cys Glu Ile Pro Ser Glu Glu 
     370                375                380
Phe Ser Lys Asp Val Ala Ala Ala Ala Ala Asp Ser Pro Asn Lys His 
 385                390                395                400
Val Ser Val Pro Asp Arg Ile Thr Gly Arg Ala Gly Leu Lys Glu Leu 
                 405                410                415
Gln Ala Val Ser Pro Ser Arg Ile Trp Asn Phe Val Glu Ile Asn Val 
             420                425                430
Ser Met Glu Glu Leu Gln Lys Leu Arg Arg Thr Arg Ile Cys His Leu 
         435                440                445
Ile Arg Pro Leu Asp Thr Val Leu Asp Asp Ser Ile Gly Cys Ala Val 
     450                455                460
Trp Phe Ala Ser Arg Gly Ile Gly Trp Leu Val Ala Gln Glu Gly Val 
 465                470                475                480
Lys Ser Tyr Gln Ser Asn Ala Lys Val Val Leu Thr Gly Ile Gly Ala 
                 485                490                495
Asp Glu Gln Leu Ala Gly Tyr Ser Arg His Arg Val Arg Phe Gln Ser 
             500                505                510
His Gly Leu Glu Gly Leu Asn Lys Glu Ile Met Met Glu Leu Gly Arg 
         515                520                525
Ile Ser Ser Arg Asn Leu Gly Arg Asp Asp Arg Val Ile Gly Asp His 
     530                535                540
Gly Lys Glu Ala Arg Phe Pro Phe Leu Asp Glu Asn Val Val Ser Phe 
 545                550                555                560
Leu Asn Ser Leu Pro Ile Trp Glu Lys Ala Asn Leu Thr Leu Pro Arg 
                 565                570                575
Gly Ile Gly Glu Lys Leu Leu Leu Arg Leu Ala Ala Val Glu Leu Gly 
             580                585                590
Leu Thr Ala Ser Ala Leu Leu Pro Lys Arg Ala Met Gln Phe Gly Ser 
         595                600                605
Arg Ile Ala Lys Met Glu Lys Ile Asn Glu Lys Ala Ser Asp Lys Cys 
     610                615                620
Gly Arg Leu Gln Ile Met Ser Leu Glu Asn Leu Ser Ile Glu Lys Glu 
 625                630                635                640
Thr Lys Leu Ter 
                 645



<210> 4314
<211> 524
<212> DNA
<213> Rattus norvegicus
<308> AA799534
<400> 4314

aatgttacc  ctccaacta  ttgccaaca  taacactgg  atattttgt  aatgtacaa  60
acagagagc  cagcccctc  tgactggtg  caggtcaca  gcagcacag  tcctcttcc  120
tgtcagaca  tgtctttaa  taaggacag  cagtacgtg  agcgtaagc  agggattcg  180
gcactgtga  gcgggcagc  cctcgccag  tggccccag  cagatacac  atggtggtc  240
gttctttct  tgcagatga  aagggaaag  tgaaccatg  tgacagagg  tggggcagg  300
gggtcgagc  actgtgagt  agaaggctg  cctccacgt  gcaggattt  ctctctgca  360
ggatacaga  tgctcagtt  gcagatctg  tggtacgtg  cctcgatga  gacgacatg  420
atgggaggg  gatgggtga  ccaagcagg  cagcagagt  atgatgggc  agagagggc  480
cctgatctc  cttgtggtt  ggcaggccc  ggtggctca  gagg  524



<210> 4315
<211> 499
<212> DNA
<213> Rattus norvegicus
<308> AA799537
<400> 4315

ataaagtac  gaaaacttt  ttggaaatc  cttgattat  tttccaagt  tagctctca  60
ttcctaaca  agcactgga  gaggggctt  acagccacc  ggtcccagc  tgagcttgg  120
tgcgggagt  gtctagagc  cgtttcttc  attgtgtag  actgagggg  acaggccac  180
ttgaaggat  cttcgctca  cttccctgg  ctctttctt  agaatctgg  acataaagg  240
tgctgtcta  aggccactg  ctgagccct  aaaagaatc  gtgccctca  ccccctttt  300
gtgctggcc  tggggggta  atcctgttc  gtaggctat  aatgtgccc  tgacccaaa  360
gctgcaatg  cacttggcc  ccactgctg  gcacatttc  ctgtggcag  aaaagcatg  420
acaggggaa  ggctctagt  ttacatgca  attactaac  gcagttgag  gcacctgct  480
caatgcgta  cggctgctg  499



<210> 4316
<211> 615
<212> DNA
<213> Rattus norvegicus
<308> AA799539
<400> 4316

actgcaaag  acctttaat  tgtttgcat  tgcagcaag  attagattt  ctcatttgg  60
caccataaa  taggtgtag  actacacag  caccgagtc  ccccaacca  tcaatccag  120
tgagtaaga  agctgaaca  aacacttct  aaaaggggt  cagtcacaa  cccagtaca  180
tttaattgt  tcaatcaaa  gcttccact  acaattgtt  ggttagtga  aaataaaga  240
agtttaaat  tttcagtaa  tcagtaatt  atcaaacct  ggtttgaat  attactgtt  300
ctattcaac  ccatccaaa  aaacatcga  actgcactc  caaacagaa  agaaaaagg  360
acagctgcg  caaatgcta  gtttgcgtt  tgagcattt  aaagaaaca  cccactctg  420
atcctttcc  ctgccactc  gctttgata  cgtgaatct  tcacatttt  cttcaacag  480
taaagcact  tgctgagaa  ataaaaagt  ataaaaatg  aatcataaa  gactaatta  540
ggtacgcat  tgaactttt  ttttantag  aacaaaaat  gtcattgtt  tctagttaa  600
taagtatct  ggtat  615



<210> 4317
<211> 2344
<212> DNA
<213> Homo sapiens
<308> AK000931
<400> 4317

tactagatg  acaggctga  gtgtttggc  gtgatgatg  ccacattca  tttgtgcag  60
aaaagccac  acgtgagaa  ggccataag  agataagta  cagttcaac  ggatgtctc  120
cttctccaa  tgctacagt  caaagccct  agcatgagt  gaaaatcgt  gcttcagaa  180
agacttcaa  taacactta  ttgtgcctg  ctgtgctgg  tggtatatt  tgtgtcatt  240
ttcttcatg  gagaaacag  ccacagagc  caccaacaa  tactccaaa  ctaagtaag  300
gtttaagct  tgagatgca  caagatgag  taatcgaaa  gcccatgtc  cctatgcag  360
acgcacgat  tggtctggg  acagcagag  tgaatggca  actcatagc  gcaggtggc  420
ataacagag  ggaatgtct  cgaacagtc  aatgctata  tccacatac  gatcactgg  480
cctttcttg  tcccatgag  acaccaaga  cccgatttc  aatggctgt  ctcatgggc  540
agctctatg  ggtaggtgg  tcaaatggc  actcagatg  cctgagttg  ggagagatg  600
atgattcaa  catagatga  tggattcct  ttccagaat  gagaactaa  cgttgtaat  660
caggagtgt  tgctctgat  catatggtc  aaaaggact  aaaaattgt  atgtatttg  720
tcctgtaac  aagttgtgg  caagctgtg  ccctcttaa  attcggaga  accagtctg  780
agtctgtga  cttggcggt  atttgtaca  aatcggagg  gcagaatct  ggaattgtc  840
gaacacagt  gaacgatac  atcctgaaa  taatacctg  actttaatt  cacccatga  900
tgtggctag  cgaggagct  gagtggctg  tcttaatgg  aaactgttt  tatgtggtg  960
ctttgatgg  tctcatgcc  tcagttgtg  ggaaatgta  gatccaact  gaaatgaat  1020
gaagatgat  ggaaatatg  cttcaccaa  gagcaatgc  gggattgca  ctgtaggga  1080
caccattta  gcagtggga  gattcgatg  caatgaatt  ctgaatacg  tggaagtct  1140
taaccttga  tcaaatgaa  ggagcccct  tacaaagat  ttccagttt  aacaaattt  1200
agaccctct  aaactaaca  gcttagtga  gtaattatg  ttagcagag  tacacttgt  1260
aataaagag  gtgggtggg  atagatgtt  ctaacagca  cacaaagct  ttgcatatt  1320
catattatt  aacatgctg  acatacttt  tgggtttat  tggaaagga  tgcaaagat  1380
aaggtctgt  ttgtgtact  ttaagactt  ggttatttt  ctttttgga  aagaataaa  1440
caagaattg  ttgggcaca  catttcaag  agtcccctc  cctccacat  tgttttgcc  1500
atttgcaca  taaatgact  ttccctcaa  tgtgtacta  ggggtaaaa  gggtagggt  1560
taaagatgt  gacagttgg  tttttttaa  ggcccttct  caataactg  aacactcta  1620
aacaaagga  acttattta  atagatgac  ttgactatt  ttgttttta  taaaaggaa  1680
cttacatgc  taccaatat  taatctttt  tgattgcct  tttataact  tttatattc  1740
cagcagagt  ctttaccaa  tgaagtaaa  tgtggcagg  tggagttat  gaagcagag  1800
ggcagtctt  agtttgcag  gtaggggtc  gtcttttaa  ctctgagtg  aaacttcag  1860
gttcttgcc  tggctgcag  ttttttcct  caagaatgc  gtactaaca  ttatttgag  1920
ggagttact  aacagtaac  tagctgtga  ttttggtat  tgaaacact  gttttaaat  1980
ttttgactt  ttgagggta  gttttatat  gcaagacat  atatagcag  aaaaaatgg  2040
gttttatct  ctatataat  cctgttttt  ttattaaca  aacagtcct  aatagcagc  2100
ctcaattgt  aaaaaattt  ctttaaact  cattaggtt  tgaatgcag  ttttatcag  2160
actatgttt  tgttcagtt  atctgttca  atggataaa  attggttgg  atgacttgg  2220
gtctaatgt  tagtgctac  cacctaact  atggggcca  aatagcatg  cctaatgct  2280
gctgctgat  taaacacat  aaaggtact  tgcaggaaa  ccttgcacc  tgggattaa  2340
atcc  2344



<210> 4318
<211> 673
<212> PRT
<213> Homo sapiens
<308> NP_005997
<400> 4318

Met Asp Leu Thr Lys Met Gly Met Ile Gln Leu Gln Asn Pro Ser His 
  1               5                  10                  15
Pro Thr Gly Leu Leu Cys Lys Ala Asn Gln Met Arg Leu Ala Gly Thr 
             20                  25                  30
Leu Cys Asp Val Val Ile Met Val Asp Ser Gln Glu Phe His Ala His 
         35                  40                  45
Arg Thr Val Leu Ala Cys Thr Ser Lys Met Phe Glu Ile Leu Phe His 
     50                  55                  60
Arg Asn Ser Gln His Tyr Thr Leu Asp Phe Leu Ser Pro Lys Thr Phe 
 65                  70                  75                  80
Gln Gln Ile Leu Glu Tyr Ala Tyr Thr Ala Thr Leu Gln Ala Lys Ala 
                 85                  90                  95
Glu Asp Leu Asp Asp Leu Leu Tyr Ala Ala Glu Ile Leu Glu Ile Glu 
             100                105                110
Tyr Leu Glu Glu Gln Cys Leu Lys Met Leu Glu Thr Ile Gln Ala Ser 
         115                120                125
Asp Asp Asn Asp Thr Glu Ala Thr Met Ala Asp Gly Gly Ala Glu Glu 
     130                135                140
Glu Glu Asp Arg Lys Ala Arg Tyr Leu Lys Asn Ile Phe Ile Ser Lys 
 145                150                155                160
His Ser Ser Glu Glu Ser Gly Tyr Ala Ser Val Ala Gly Gln Ser Leu 
                 165                170                175
Pro Gly Pro Met Val Asp Gln Ser Pro Ser Val Ser Thr Ser Phe Gly 
             180                185                190
Leu Ser Ala Met Ser Pro Thr Lys Ala Ala Val Asp Ser Leu Met Thr 
         195                200                205
Ile Gly Gln Ser Leu Leu Gln Gly Thr Leu Gln Pro Pro Ala Gly Pro 
     210                215                220
Glu Glu Pro Thr Leu Ala Gly Gly Gly Arg His Pro Gly Val Ala Glu 
 225                230                235                240
Val Lys Thr Glu Met Met Gln Val Asp Glu Val Pro Ser Gln Asp Ser 
                 245                250                255
Pro Gly Ala Ala Glu Ser Ser Ile Ser Gly Gly Met Gly Asp Lys Val 
             260                265                270
Glu Glu Arg Gly Lys Glu Gly Pro Gly Thr Pro Thr Arg Ser Ser Val 
         275                280                285
Ile Thr Ser Ala Arg Glu Leu His Tyr Gly Arg Glu Glu Ser Ala Glu 
     290                295                300
Gln Val Pro Pro Pro Ala Glu Ala Gly Gln Ala Pro Thr Gly Arg Pro 
 305                310                315                320
Glu His Pro Ala Pro Pro Pro Glu Lys His Leu Gly Ile Tyr Ser Val 
                 325                330                335
Leu Pro Asn His Lys Ala Asp Ala Val Leu Ser Met Pro Ser Ser Val 
             340                345                350
Thr Ser Gly Leu His Val Gln Pro Ala Leu Ala Val Ser Met Asp Phe 
         355                360                365
Ser Thr Tyr Gly Gly Leu Leu Pro Gln Gly Phe Ile Gln Arg Glu Leu 
     370                375                380
Phe Ser Lys Leu Gly Glu Leu Ala Val Gly Met Lys Ser Glu Ser Arg 
 385                390                395                400
Thr Ile Gly Glu Gln Cys Ser Val Cys Gly Val Glu Leu Pro Asp Asn 
                 405                410                415
Glu Ala Val Glu Gln His Arg Lys Leu His Ser Gly Met Lys Thr Tyr 
             420                425                430
Gly Cys Glu Leu Cys Gly Lys Arg Phe Leu Asp Ser Leu Arg Leu Arg 
         435                440                445
Met His Leu Leu Ala His Ser Ala Gly Ala Lys Ala Phe Val Cys Asp 
     450                455                460
Gln Cys Gly Ala Gln Phe Ser Lys Glu Asp Ala Leu Glu Thr His Arg 
 465                470                475                480
Gln Thr His Thr Gly Thr Asp Met Ala Val Phe Cys Leu Leu Cys Gly 
                 485                490                495
Lys Arg Phe Gln Ala Gln Ser Ala Leu Gln Gln His Met Glu Val His 
             500                505                510
Ala Gly Val Arg Ser Tyr Ile Cys Ser Glu Cys Asn Arg Thr Phe Pro 
         515                520                525
Ser His Thr Ala Leu Lys Arg His Leu Arg Ser His Thr Gly Asp His 
     530                535                540
Pro Tyr Glu Cys Glu Phe Cys Gly Ser Cys Phe Arg Asp Glu Ser Thr 
 545                550                555                560
Leu Lys Ser His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys 
                 565                570                575
Asn Gly Cys Gly Lys Lys Phe Ser Leu Lys His Gln Leu Glu Thr His 
             580                585                590
Tyr Arg Val His Thr Gly Glu Lys Pro Phe Glu Cys Lys Leu Cys His 
         595                600                605
Gln Arg Ser Arg Asp Tyr Ser Ala Met Ile Lys His Leu Arg Thr His 
     610                615                620
Asn Gly Ala Ser Pro Tyr Gln Cys Thr Ile Cys Thr Glu Tyr Cys Pro 
 625                630                635                640
Ser Leu Ser Ser Met Gln Lys His Met Lys Gly His Lys Pro Glu Glu 
                 645                650                655
Ile Pro Pro Asp Trp Arg Ile Glu Lys Thr Tyr Leu Tyr Leu Cys Tyr 
             660                665                670
Val 
         675



<210> 4319
<211> 553
<212> DNA
<213> Rattus norvegicus
<308> AA799542
<400> 4319

caaggattt  ttaagtcat  catgcaaaa  atactgcta  ctgcattag  aaaagatca  60
tgtaaaaac  ctccacaat  ctgcaactg  caattgaaa  aagtttgtt  tagaggtcg  120
aaggcccaa  actgtgttc  tgccagtga  ttaggttgt  cagaacggc  ttagcacta  180
cgcttgaca  aacctcaca  acccaaagg  acgggaagc  tgtgtccgc  tgggtgagg  240
ctaaagggg  cggcatcaa  cacatgaca  tgttggtac  ctggcaaga  agtgatgtt  300
cagaatatc  aaaatagtt  acaaactgt  aagccgcat  acgtgattt  tacacccag  360
tactacaaa  cgacgggaa  cactactca  ctgattaaa  gaaggtgaa  acaggaacg  420
acttctact  tctaccaga  aatctccga  tgcattatc  gaaagatct  atagaacag  480
tcagacata  tgctcgtta  gaagaggtc  taaagaaaa  acttgctaa  ttagcaact  540
tgagggatg  cac  553



<210> 4320
<211> 28567
<212> DNA
<213> Homo sapiens
<308> AJ132695
<400> 4320

gtttcacca  gttggtgag  ctggtctca  actcctgaa  ttgtgatcc  cccacctgg  60
ccgcccaac  aaagtgctg  gatgacaga  gtgagccac  gcgcccagc  accacaggt  120
cctcttttt  ttttttttt  ttgagacgg  gtctcgctc  gactccagg  tggagtgca  180
tggcgccat  tgggctcac  gaaaccacc  cctcccagg  tcaagagat  ctcctgcct  240
aggctcctg  gtagctgga  ctacaggcg  gcgcctcca  gccctgcta  tctaatttt  300
gtattttta  tagagacgg  gtttcacca  gttggccag  atggtctcg  tctcttgac  360
ttgtgatcc  ccctcctcg  cctcccaaa  tgctgggtt  acaggcttg  gccaccgcg  420
cctgtctga  aggttcctc  tttttgttt  tgttttttt  tttgagacg  agtttcgct  480
ttgtcgccc  ggctggagt  caatagcag  atctcggct  actgcaacc  ctgcctccc  540
ggttgaagt  attcacctg  ctcagcctc  tgagtagct  ggattacag  cgcccacca  600
cacgccccg  taatttttt  tatttttat  agagacagt  tttcaccat  ttggccagg  660
tggtcttga  ctcgtgacc  caggtgatc  gcccgcctc  gcctcccaa  gtgttggga  720
tacggacgt  agccaccgc  ccgagctga  aggttcctc  taaagccct  agtcccagg  780
aagggacct  caggcccgg  cacgcccag  ccgctttag  gcgcaagat  gcggcatgc  840
cgccccgcg  ccggagccg  gtgggcccg  gcgcttccg  gcattcccg  agtccagag  900
aactccggg  gcggcgcgg  cgggagcgg  cggccggga  cggccccgc  cggaacctg  960
gagcggcgg  gccggcgcg  gggagggga  gccggatgt  agtggagcg  ccatttcct  1020
tttctctgc  gttttcctc  gctttgggt  gtggccgct  ccgggcatc  gcttccagt  1080
cgcggaggg  gaggcggcg  ggacagcgg  cccggcacc  agcgccccg  cgcccgcaa  1140
ccgcgcgcc  gtccgccgc  ccccgagcc  gccgcttcc  atctcagcg  cctgccgcc  1200
ccgccgcgg  ccagcgagc  gccctgatg  aggccatca  gtgtgtggt  gtgggagac  1260
ggtgagtgc  cggccgggg  cgggctgga  gccgcggga  cgggcgcgg  ggggggttg  1320
gcccggact  gggcccagg  aggccggcg  ccgcgcggt  tcgcgtagg  ggtgggcct  1380
ggcctgtgt  gcggggcgg  ggccgcggc  ggcgccccc  ccggaccct  acggcccgg  1440
cggcgcgtg  ctggttccg  ctctcgatg  aggagggcc  cgccgctcg  cggctagag  1500
gaaaagtga  ctccaccct  cggctttct  cccggacgc  gcccgccgc  ctcctcggg  1560
gcgctcgta  agcaagcgc  cttggagat  ttgaccatt  ttccaaaaa  ggacccttt  1620
ttttttttg  atgaacctc  cgatcccct  ttgagaatt  ggttgggaa  gcggcggtc  1680
agtcgatca  atttgatgc  tgcttgatt  tacgggccg  tttggtgcc  ccaaacttt  1740
ctttaaaaa  atttttttt  catagacgg  gtctcgctg  gttgcccag  ccggtctcg  1800
actcctggg  tcaagcaat  ctcccatcc  agcctccaa  atgctggga  tacaggcgt  1860
tgccaccac  cctggctaa  ctttaaaag  tttttgtag  aatggggtc  cactgtgtt  1920
tccaggctg  tctcgaatt  ctgcgctca  gtgattctc  tgcctctca  cctccaaaa  1980
cgctggggt  acaccgcgc  cggcctctc  acttatttt  gacaggttt  ttgacttac  2040
cttctgcca  tgttaggat  cttaaaatt  ttttcgccc  ttccgtgga  aaagttttg  2100
agatgctgg  tgggaggag  cggctgtaa  gggggactg  tttttcttt  ctttctttc  2160
ttttttttt  taaacaacg  ggtgtggtc  ttgacaaaa  aactgttct  tgcttaacg  2220
gttaggtat  ggatgtagc  gaactggcc  cctgtgact  caggcattg  ttttcatga  2280
tgtccgtga  ggttacagg  cctagagga  gacaaaact  gtcttatgc  gtttttttc  2340
cccatagaa  caagaatct  agtgtaacc  gagcaaaat  gcgcgtctc  gcgttgctt  2400
tataggtta  tgttagcga  gaagaatta  taccagttt  atcaaactc  atgcaactg  2460
tacatgttg  agtaaagtc  aaggaaagt  ctggcatca  ggttaactg  attgatatt  2520
ttcaaactt  tcattagga  agattttgg  tcttgcaat  cagatgcaa  aaggataat  2580
agacagctg  tttttgtaa  atgcccatc  gtcggattt  tcttggaag  gtgaaggag  2640
attagagta  gtaggctat  caggctttt  ttttttttt  ttttttttt  agacggagt  2700
tcactctgt  gcccaggct  gagtgcagt  gcacgattt  ggctcacta  aacctccgc  2760
tcccaggtt  aagcgatcc  cctgcctca  tgtccttag  agctgggat  acaggcacg  2820
gccaccgtg  ccggctaat  tttgtattt  ttagtagag  cggggtttc  ccatgttgg  2880
ctggctggt  tcgaattcc  gacctcagg  gatccaccc  cctgggtct  ccagagtgt  2940
gggattaca  gcgtaagcc  cggcgcccg  cccaatttt  ttttttttt  ttttctttt  3000
ttttttttt  agacggggt  tcactctgt  gcccaggct  gagtgcaat  gcgcgatct  3060
tgctcctgc  acctctgcc  cccgggttc  agcgattct  gtgccttag  ctcccaagt  3120
gctgggatt  caggcgcaa  ccaccatgc  cagctaatt  gtttttttt  ttttttttt  3180
tattttttt  gtggagacg  agtttcacc  tgttggtga  gctggtctc  aactcctga  3240
cctcaagtg  tccgcccgc  tcggcctgt  ttttttttt  ttttttttt  agtcatatt  3300
ctgataatt  tttgaaaat  tctaaaact  aaacataag  atagcagat  cgtttattt  3360
atactaacc  attgtggac  tctgctgtt  gaattggct  ttttatcta  tcaaataac  3420
tgttgaatg  catggaatc  ggaccgtcc  ttcaaatcc  caccccacc  cttacatgg  3480
gtaacccta  gcacatccc  cacctccca  gagaggcgg  tcaatggga  gtcaacaag  3540
ctaaacaag  tgttggtta  taactacct  gcaggtgcc  cttgctgaa  gcttagtaa  3600
tgccaggta  tgttattgc  gtttctact  ctgagactc  gtgagggag  attaggctt  3660
aaagtctgt  gccttgagt  ttcagtctg  ttttttttt  taattagtt  tgagcattt  3720
aacaagcac  gttattttt  aatactatg  ttagtattg  tgttgacta  agctaagtg  3780
tattagaag  gaaatgtac  tggccaggt  aggtggctc  cacctgtaa  ccagcattt  3840
gggaggcca  ggtgggtgg  tcactagag  ttaggagtt  aagaccagc  tgggcaaca  3900
ggcgagacc  tgtctctgc  aaaaataca  aaattagct  ggtgtagac  catgtgcct  3960
tagtcccag  tactcggga  gctaaggtg  gaggatcgc  tgaaaccca  gaggtggag  4020
ttgtagtga  ctgagattg  gccattgca  tccagcccg  gcgacagag  gagaccttg  4080
ctcaaaaaa  caaaaacaa  aactattag  gatacgtct  tggccgggc  cggtagctc  4140
agcctgtaa  cccagcact  tgggaggcc  aggtgggcg  ttcacctga  gtcaggagt  4200
tgagaccag  ctggccaat  tggcgaaac  tcgtctcta  taaaaatag  aaaattagc  4260
gggcacgcc  gtaatccta  ctattcagg  ggttgaggc  ggagaatcg  ttgaacttg  4320
gaggtggag  ttgcagtga  ccaagattg  accattgca  tccagcttg  gtgacagag  4380
gaaactgtc  ttttttgtt  gtttgtttt  aaaggagat  catcttcat  tgttcctgc  4440
ttgaccctt  gcctggacc  tggcagtgt  ctttcaggc  gtacgtccc  ccatcctgc  4500
ctcctgtgc  tctgcttac  ctgggctct  aaggaaact  ctgctcctt  tctcatcat  4560
cctagggat  gttctgtct  atcatttct  gaattggat  ccttgccat  ttgtttgct  4620
cttaactct  catacaggg  tgtgtaaat  attccttca  gaaaatctc  atttcaatc  4680
tctgggatg  gttttttcc  tctgggacc  tgactgata  agactgata  tacacccgt  4740
tgaaaatat  tctgccagg  gcggtggct  atgcctgta  tctcagcac  ttgggaggc  4800
gaggcaggc  gatcacctg  ggtcaggag  tcgagacca  cctggccaa  atggcaaaa  4860
cctgtctct  ctaaaagta  aaaaattag  cgggcgtgg  ggtgggcgc  tgtaatccc  4920
gctactcag  atgctgagg  aggagaatc  cttgaaccc  gaaggcgga  gttgcagtg  4980
gctgagatt  tgtcactgc  ctccagcct  ggcgacaag  gcaaggctc  gtcttgaaa  5040
aaaaagaaa  aaagtcaga  ataatttgc  aagcatgtt  gaaaattct  gatttcctg  5100
atagcaatt  aattgagat  ggccaagaa  tattacata  ggttgatac  cttttattc  5160
aagatagtc  tttctgagc  tggggtcta  aattttttt  tcctccacc  tactgctgc  5220
ccacctttt  actttcact  agtggacct  tgccccaag  ttttctctc  gcttttcct  5280
ggtaagaca  catcacccg  gcgcgatgg  tcatgcctg  aatcccaga  ctttgggag  5340
ccaaggcag  cggattgcc  gaagtcagg  gttcgagac  agtctggcc  atatggtga  5400
accctgtct  tactaaaaa  acaaaaaaa  tagccaagg  tggtggggg  cgcctgtaa  5460
cctagctac  cgggaggct  aggcagggg  attgtttga  tcaagggag  tggaagttg  5520
agtgagcca  tatcgtgcc  ctgcactcc  gcctgggta  cagagtgag  ctccgtctc  5580
aaaaggaaa  aaaagacag  atcttacat  caggtattt  taaacaact  ttattattt  5640
tttgttttt  ttttatatt  gctcactgc  gcctccacc  cctgggttc  agtgattct  5700
ctgcgtcag  ctcccaagt  gctggaact  cacgtgcct  ctaccatgc  gaggtaatt  5760
ttttttttt  ttttttttt  agaaggagt  ttcgccctt  ttgcaaagg  tggagtgca  5820
tggtgcgat  tcggctcac  gcaacctcc  cctcctggg  tcaagcgat  ctcctgcct  5880
agcttgtcg  gtaggtggg  ttacagtca  gctccacca  actgactaa  ttcgtattt  5940
taatagaga  gaggtttct  cttgttagc  aggttggtc  caaacgcct  acctcaggt  6000
atccacctg  cttagcctc  caaaaagta  tgggattac  ggcatgagc  actacgcct  6060
gcaattttt  gtattttta  tagagacag  gtttcacca  gttgaccag  ttggtttcg  6120
actcctgac  ttaggcgat  tgcccgcct  ggcctccca  agtgctggg  ttatgggcg  6180
gagccatcg  ccctggcct  aacaacagt  ttattattt  attttttat  tttttattg  6240
ttattacta  tttttgaga  ggagtctcg  tctgtcacc  aggccgggg  gcagtggca  6300
gatatgggc  catggcaac  tctgcctcc  gggttcaag  agttctcct  ctttggcct  6360
ccaaagtga  ggaattaca  gcccgagcc  ctgcgcccg  ccacaacta  tttaatagt  6420
ttgttttgg  gttggttga  taaaggaat  ggaacgaat  acttgaagc  ctctctgtt  6480
cactcttta  acaaagtgg  gtccagatt  ggctagtgg  ctgtctagc  caatgtctg  6540
cttggacat  cattactgt  caggagttt  ttagctgaa  gtgaaaaat  ccttccgtg  6600
catcatcct  acaggaaca  tctttacat  tattcttta  ttctgttga  cggtggtgg  6660
gtgaaccat  aatttgttt  agcttttca  ctgttttgt  tgttttcct  tcaaggcat  6720
gggtttcat  tttttgacc  gtggtaaag  tatttgaat  ctgcactgg  ctccaaatg  6780
aggtgtagt  tatggctct  atctttgtt  atgatttta  acataatgt  gtttttttt  6840
ttgataagc  aaaaaaatt  tacataatg  gtgtgtgtg  gtgtgtttt  atttcaaat  6900
atagttaca  taaaagttt  gagttgggc  aagtgggag  agcatcagg  agccatttt  6960
agaaacctt  aattcaccc  ttataactt  ctgtctttt  gcattagtc  tctgatacc  7020
tagtactgc  tactttttc  catctccat  actacgtag  tcttaaaat  gtagtcttc  7080
ttgaaagga  atgtttttg  caagagtct  tgccaccaa  gcaggattg  atgtgatca  7140
taggaatat  ttcctgcaa  gtcttaata  gaaaaattt  aaacagact  gtggaaagc  7200
ttgtacagt  aacatgcac  tacccatgg  ctggattct  tgacagtat  ttgctctac  7260
tgttcattt  gctgtattt  ctttatcat  tcttcctgt  atcagaggg  accttttaa  7320
aggatttat  gaggagttg  ttttgtttt  tgttttgtt  tgttttgct  tttttgagg  7380
ggagtcttg  tctgttgcc  aggctggag  gcaatggca  gatctctgc  cactgcaat  7440
tccgcatcc  aggttcagg  gattctcct  cctcagcct  ctgagtagc  gggcttaca  7500
gcacccacc  ccatgcctg  ctaattttt  tattcttag  tgagacagg  ttcaccatc  7560
tggccaggc  ggtctggaa  tcctgacct  aggtgatcc  cctgcctcg  cctcccaaa  7620
tgatgggat  acaggcgtc  gccaccatg  ccggcctga  tttgaaaaa  aatagggac  7680
gtgtgcagt  acatataaa  tcttatttt  gaactcttg  gtgttcagc  ggcttgtat  7740
aactacacc  gggttagcc  tgattctgg  agggtggat  cagacttca  ctcagttgt  7800
catagtgtc  tcagcctaa  tgagaaact  tatgcacta  cttaatttt  tgaagcttc  7860
agtggtaat  attgctggc  ttttttttt  ttttttggt  gaaacagag  cttgctctg  7920
cgccaggct  gagtgcagt  gcacgaaat  agctcactg  aacctctgc  tcccaggtt  7980
aagcaattc  cctgcctca  cctcctgag  agctgagat  acaggcgtg  gccaccaca  8040
ccagctaat  tcttttgta  tttagtaga  acggggttt  actgtgctg  ccaggctgg  8100
cttgaactc  taaggtcag  cagtccgcc  accttgccc  cctaaagtg  taggattac  8160
ggcatgagc  accgtgcct  gcttatggc  agctttctt  acattgatt  tgaagtcag  8220
tattggtag  agaacatca  aattttaga  tgggttttg  gtttattta  cactgcact  8280
ctctagtgg  gtatttttc  ggacagatt  tatctgcat  gttaacgca  ttatatata  8340
ggcctaccg  tacagaatc  ccatacctt  tttgtcagt  taaatcgag  accttcatg  8400
gaggtcttt  atttattca  taagtagga  tatatattt  acagttact  aattctact  8460
ccttgtcct  aagatctac  tactttttt  tgttttttg  gtcagagag  ctcgctctg  8520
tgctcaggc  ggagtgcag  gatgcgatc  cagctcact  caacctcta  cccgtggcc  8580
caagcgata  ttctgcctc  gcctcctga  tagctggga  tacaggcgc  tgccaccac  8640
ctcagctaa  tttttgtat  tttaataga  atgcagttt  gctgtgttg  tcagtctgg  8700
ctcgaactc  tggcctgaa  tgatccacc  gccttggcc  cttgctggg  ttacaggga  8760
gagccactg  gcctggcca  gatctactc  cttttagac  gcaatatat  ctctgtatt  8820
tggtttgca  ttgtaattg  cattggaag  gtttggctt  tctgtcctg  gatcaacgt  8880
tctttaaaa  aaggcagtg  agaaagttg  tattttttg  gcttcttgg  tcttttatt  8940
ttttaacgt  aggaaattc  tagcgtttc  agatttgtt  attgtgctt  taagttttg  9000
tttatagat  tcaggaagt  acactaaag  ttaccctac  ctcctcaaa  agtaagtaa  9060
aagttctct  ggctgggcg  ggtggctca  gcctgtaac  ccagcactt  gggaggccg  9120
tggggtgga  ctcctgagg  caggaattc  agaccagtc  ggccaacat  gcaaaaccc  9180
gtctctact  aaaatacaa  aacaaaaaa  aattagctg  atgtggtgg  gcttacgtg  9240
agtcccagc  acttgggag  ctgaggcag  agaattgtt  gaacccagc  ggcagaggt  9300
gtggtaagc  aggattgca  cattgggct  cagcctgga  gacagagcc  agactccgt  9360
ttaaagttc  cttaatgga  aaatgaaga  cataatagc  acataagtt  tttgctttc  9420
ttgtggtta  ttctacagg  cagggcagg  gaagcacag  taggttaaa  aaaattgta  9480
catcatgag  tagggggaa  tccaatgta  aaatggcat  aactttctt  cagccgact  9540
atgttcgtt  cctagagtg  tgacattgc  cgatgattg  aaagaggtt  aactgagca  9600
ttaattata  aaagttaga  attccaaag  agtagtaac  accagaaat  ctccagcag  9660
atcagtcaa  acttgtggc  aaatacggc  tccattctt  atgagggaa  ggccatgga  9720
aggctgtca  attgcccag  gcagatgtt  acttggttt  tggaagcgc  gcgtggaca  9780
ggaatgaat  tacactaat  ggagtggaa  aaccttttt  ttttaccta  ttgaataaa  9840
taagtaaaa  ttttaatca  aagacttaa  gaggagtcg  ttttatctt  tgattgcac  9900
aagcttaaa  ataaggttg  actttaaga  ttctgtagt  taataatca  attcttata  9960
gacatagat  tgtaacaaa  agtgattgg  aataaaatt  cagtcagta  cagattatg  10020
cagtacctt  aatttcttc  cggttgagc  tttctcagc  aaagatgtc  ttcaggaaa  10080
gaagtttag  ggattttag  cacagctgg  tgcctttat  ttagtagtt  tgttcctca  10140
atacataga  acttaggac  gaatagtaa  agaagtgat  atgacattt  atcataaca  10200
tcaaaacct  catagcagc  tatccttga  actgagtgg  aactattgt  aaggttttt  10260
cacaacctt  atctttttt  ttttttttt  ttttttttt  ttttttttg  gacggagtt  10320
tgctcttgt  gcccaggct  gagtgcaat  gcgcaatct  ggctcactg  aacttccgc  10380
tcccgggtt  aagcgactc  cctgcttca  cctcccgag  agctgggat  acaggcatg  10440
acgcccggc  aattttgta  ttttagtag  gaggggttt  tccatgttg  tcaggctct  10500
ctcgaattc  tgacctcag  tgatccgcc  gccttggcc  cccaaagtg  tgggattac  10560
tgtgtgagc  accgagccc  gccaacctt  atcattttt  aaaaggtcc  ttagagcct  10620
aggctccac  ttcttcctc  gctgccaca  ccaaaccat  ggtaagcga  gcttgatct  10680
cctccaagt  caagcagtc  aggaaacag  ccacttatg  tcactgtcc  gtccccatt  10740
ttggtccag  ccaccatgg  tggctcctg  actgtagca  cagcttcca  gtgtgtctg  10800
cttgactga  tccctggcg  cctcaggct  cctgccaca  tgcagttgg  ggcttcttc  10860
aaaatccag  gctttctgg  caatttaaa  cctgtgact  tccaagtag  atctagtcc  10920
catgtcctt  acaagaaga  gtaacgtat  tccctatgc  actgcccac  tattttttt  10980
ttgttgaga  gggatcgtg  tttgtcacc  aggctgggt  gagtggtgt  atcacagct  11040
actgctgcc  tgaattcct  ggctgaagg  atcctcttg  ttcagcctc  tgagtagct  11100
ggactacag  caagagcca  cacttattt  tgaattttt  gtggaaaca  ggtctccct  11160
tgttgccca  gctggtctt  aactcctgg  ctcagcgat  ctcccacct  aggcccctg  11220
gctgggatt  tagcctcct  tgctgggat  acaggccta  gccactgca  caggctttt  11280
ttttttaat  taaaaaaat  tattttttt  agacagggt  tcactttgt  cctcagact  11340
gatgcactg  tgcaatctt  tttcactgc  gccttgacc  ccctcctgg  ttcaagtga  11400
cctcgtgcc  cagcccccc  agtagctga  actactgct  cacaccgcc  cacccacct  11460
atttttgta  ttttagtag  gaacgggtt  ctccatgtt  gcccagctg  tcttgaact  11520
ctgggctca  gcgatccac  cacctcagc  tcccaaagt  ctaggatta  aggcatgag  11580
caccatgcc  ggcctaaaa  tattttttt  agctctaga  atgttagct  ttttgctgt  11640
catttccag  gctgcttta  taatgacag  tatcacacg  ataatttca  gtgatgatt  11700
cattcttaa  ttttaaatt  aacaactgc  cttacttca  gaggtcttg  tcattgata  11760
atctttagc  cctagtgtg  ttctggtgt  gcacacggt  gatataaat  gaaattgaa  11820
taatgctca  agtagtttg  ggatggagc  ggtagttct  cattaattt  gcaggtgaa  11880
aaaaaaggc  tgaggaagt  gaaacttgc  aaaaaatac  gccagtacg  gctagaatt  11940
gccctgggt  tcaaatctg  gcttctgac  ccaaagctt  ggctcctgc  catacaggt  12000
tattttcac  ttctaagct  ttaacgaaa  gtatgtcca  tgagtcatt  ctgtttaga  12060
agcctttag  agttggaag  tacttcctg  tgatgtaat  tttgactct  taaagtctt  12120
ggaatgggg  gttccaact  ttgttaagc  ctcaataat  tcatgagtg  atgaatatt  12180
gcaagactg  ctgggcctg  aatctgcct  gagtgtgag  gaaaatgga  aagcgctta  12240
ctttatggt  aattctaat  tatagtagt  gagattgaa  gacaaaaat  ttaaaatta  12300
gatgctgat  tgtcattgt  accttggta  actgacagc  cagcagaga  aagggctca  12360
taaggagag  acttggcta  ctgaaccct  aggatgcca  agacttgaa  tctcatgta  12420
gcccttaag  ttgccttgt  aatgctgta  aaattggag  cctttatgt  ttgctaatg  12480
tgtggtgac  ttagttatt  ggtgatagc  tcttgaaaa  cattccagg  ggttgggag  12540
ctttcagcc  ccactcttc  gcctggcgg  acactggta  tattaggat  agtctctac  12600
cattgccag  tgtgcaggt  gtgctcctt  ctctgaagt  tttctacac  cttctctgt  12660
tggcaagtt  aactcccat  gtctctgag  tgttaatta  atgtctggg  tgtattgtg  12720
tagtccctg  ttatagact  atggtgctg  gtgaggatt  gggctgggg  aggtggcat  12780
taaatacag  tgaatcaat  tgatggcag  tacgtgtgg  agtttattg  ctaagcact  12840
tctctcaag  gaacagtca  tgctgattg  catagggga  gctgtaggg  tgtggtggg  12900
ttttgagct  tcccactta  ggcagcaga  taagttact  aaagaggaa  gctgtgttt  12960
tatattagt  ttaattaaa  tacctttag  ctgggtgtg  tggctccag  ctgtaatcc  13020
agcactttg  gaggtccag  tgggcggat  acttgaggt  aggagttcg  gaccagcct  13080
gccaacatg  cgaaaaccc  tctctacta  aaatacaaa  aaattatcc  ggcgtggtg  13140
tggacagct  taatcccag  tacttggga  gctgaggca  gagaatcgc  tgaacctgg  13200
aggcagagg  tgcagtgag  caagatggt  cctctgcac  gcactccag  tggggcgac  13260
gcacgagac  cggtctcaa  aaaaaaaaa  aaagaaaaa  aagaaaaaa  gaaaatatc  13320
tcaggatca  acttaagat  cttgatgag  ggctctaca  atgttcaca  aagagacgt  13380
aagttttaa  atcttgttt  tcttgagtc  tgtagctag  tgacaactg  ttcttgact  13440
ttaatgcta  caccgggta  ctaaacaga  tgtgatggc  cctgactct  tctttctga  13500
aaattctag  ttgtttact  taaatttca  ggtaccaat  tgtatgtgg  gataaaggg  13560
tatagaaaa  attttcttt  atgctaagt  tgtgatgta  atgccttga  tttttttct  13620
tagaaatta  tttaactta  tagtgaaag  taagattac  ttcatgttg  ctaagcaac  13680
ttttttctc  ttctcttta  agctgtagg  aaaacttgc  tactgatca  ttacacaac  13740
aatgcattt  ctggagaat  tatccctac  gtgtaagta  cttaaattg  gaattaacc  13800
gtttgtgtt  cgggtttca  atttctttg  ccatttgtt  tgctgtaaa  ccatcttta  13860
tcctcatat  aacagatac  aattttttc  taaacattc  ctgaaacct  attataagg  13920
atattaggc  tttaaaaaa  agggctggg  gtggtgatc  cagcacttt  ggagactga  13980
gcgggtgga  caactgagg  tcaggagtt  gagaccagc  tggtcaacg  gatgaaacc  14040
catctctac  aaaaataca  aaaattagc  aggtgtggt  gcgggtgcc  gtaatccca  14100
atacttggg  ggctgaggc  ggagaatca  tcgaaccgt  gaggcggag  ttgcagtga  14160
ccaagatca  gccactgca  tccagcctg  gcaatgaga  cgaaactcc  tctcaaaag  14220
aaaaaaaaa  agaaactta  ggtaatata  acttttcac  actttgcta  ttgattttt  14280
gacatccag  aagcaaact  taactgtct  tgaggtaca  agactggat  atgttaaag  14340
aaaccatag  tggacacaa  aactctgac  aaaagtctg  tcagaaaca  tccttgtca  14400
tgcacgagt  tcagataca  tggctttct  ggaactgga  agggaaaga  tccattacg  14460
tttaattgg  cttttctga  aagtcatca  ttggttaca  gtccgcatt  aggtgtagg  14520
ctttggaat  gaaacttgg  tgtgtgtgt  gaaggggga  tgggagggt  gaattggct  14580
ttgaattgc  tactcccta  aggcagcag  attgggtgg  gacaggaaa  tgctgctct  14640
gtgatgggt  acccgggag  gcacgtagc  gagcctcat  atgcaccat  ctgcagctg  14700
tgtgagtcc  ccctgtgca  gctggggag  tgtcgcctc  tccccacct  tgttcacct  14760
ctcaggcac  acacacacc  aggtgctct  tgaagtgtc  tacccatgt  tttgttgtt  14820
ttgttgttg  tttcctttt  ttttttttt  tttggagtt  gtctctctc  cttgcccag  14880
atggagtgc  gtgatgcga  ctcagctca  tgcagcgtc  gcctcctgg  ttcaagtga  14940
tctctgcct  agcctccca  gtagctgtg  ttacaggca  acaccacca  acctggcta  15000
tttttgttt  tttagtaga  acgggtttc  ccatgttgg  caggttggt  tcaaactcc  15060
gacctcagg  gatctgccc  cttcagcct  ccaaagtgc  gggattaca  gcgtgagcc  15120
cggcaccca  tttttactg  aagtggaat  atgctgtcc  tgttgtcct  aatttatgg  15180
ggagatttt  cttatctac  tatgtagat  aaggtttaa  cattaatga  taatgattt  15240
gaagtacta  aactgattt  acccactgg  cacttggac  cttggtgtt  acaaacatt  15300
ctgggttca  tgttgtccc  tatgtcttt  tgtacactt  atagattat  agaagcaaa  15360
tcgtgccaa  tcaaaagac  atggatgtt  taaattttg  tagatacag  tgggcgtga  15420
tgctcacgc  tgtaatccc  gcactttgg  aggccaaga  ggaaggatc  cttgaggtc  15480
ggagttcga  accaacctg  ccaacatgt  aaaaccccc  cctctgcta  aaatacagt  15540
gttagccgg  tgtggtggt  cactcctgt  gtcccagct  ctcaggagg  tgaggcatg  15600
gaattgctt  aacccggga  gcagaggtt  cagtgagcc  agattgtgc  actgcactt  15660
agcctgggt  acagagtga  actctgtct  ccaaaaaaa  aaaaaaatt  aaaaattat  15720
ttttggtag  taactacca  attgctgtc  ataaagctg  cactttgct  gccttgact  15780
aagtggcct  ttagtacac  ctgccatta  cgtgggttg  agttatcta  ccgttttca  15840
ttccaatca  agatgtggt  aaaatcttt  gaatttttt  tttttttaa  taaaaaagt  15900
tgctcacgc  tgtaatccc  gcacttggg  aggctgagc  gggcggatc  ctgaggtaa  15960
gagtttgag  ccaacttgg  caagatggt  aaaccctgt  tctactaaa  atacaaaaa  16020
tagctgggc  tggtggcac  tgactataa  cccagctat  cgggaggct  aggcaggag  16080
attgcttga  cctgggagg  ggaggttgc  gtgagccaa  attgtgcct  tgcactcca  16140
cctgggcaa  agaacaaga  attgtctcc  aaaaagaaa  aaaaaatat  tgtttttgt  16200
gagctatgt  ttgctatat  gcccaggct  gtcttgaag  cctggcctc  ggtgattct  16260
caccttggt  tcccgaagt  ttgggatta  aggcgtgag  caccacacc  ggctctttt  16320
aatgtttac  gtacatttt  agtctcttg  gaattgtct  tttaaatct  ttgtatttt  16380
ctactgaaa  tttttctta  tgatggaac  tttccttcc  tccttccct  cctccctct  16440
tccctccct  cctcccttc  tttcttccc  ccctcctcc  ctccctccc  ctctccctc  16500
ttccctcct  tcctactcc  tccctcctt  cctccttcc  tctcctttc  tttcccctc  16560
ctcccttgc  ccctccctc  ctccctttt  ttttttttt  ttttttgag  tggggtctt  16620
cagtattgc  caggccgga  ttgaagtac  ggtccttcc  cctcagcct  ttgagtagc  16680
tgctccact  cacgtagcc  gatggaacg  tttgtaaat  atcctcagt  tgtcatttg  16740
ctttgtact  cattatggt  tcttctgcc  tatagaaat  tagcattta  tgtaaataa  16800
accacctta  ccgggcacg  tggctcaca  ctgtaattc  agcactttg  gaagctgag  16860
tgggcgcat  atgaggtca  gagatcaag  ccagcctga  caacatggt  aaaccccat  16920
tctactaaa  atacaaaaa  taaccgggc  tggtggcgt  cacctgtaa  cccagctcc  16980
caggaggct  aggcaggag  atcacttga  cccaggagg  ggaggttgc  gtgagccga  17040
atcgcacca  tgcactcca  cctgggtga  agtgagatt  tgtctcaaa  aaaaaataa  17100
aataataat  ataatacca  ctctccctc  gaattgtat  ttgtactta  aaaggcctt  17160
cctacttaa  taatgcaaa  gtatgctct  gtatttttt  ctaggattt  tgtggctaa  17220
atttttatc  ttaattcat  taggactta  ttttggtat  gaatgaggc  aggacctga  17280
tctttttcc  ttatgggga  aaaaagtca  aatactatt  atccaataa  ttttttctt  17340
tggaaatat  attaacatg  ccatcacca  cacaccttt  ctttcttct  cttcttttt  17400
cttgagacc  agtttcgca  ttgttgccc  ggccggagt  cagtggcgc  acttggccc  17460
ctgcaacct  tgcttcccg  gttcaagcg  ttctcttgc  tcagcctcc  aagtagctg  17520
gactacagg  gcctgtcac  acgccctgg  taatttttg  atttttagt  gacacaaag  17580
ttcgtcatg  tggccaggc  ggtctcgaa  tcttgacct  aggtgatcc  cccacctcg  17640
cctcccaaa  tgctgggat  acaggcgtg  gccaccgtg  ccagcctct  ctttttatt  17700
tatttttcc  ttttttttt  ttctttttt  ccttcctgt  cagaggaaa  actattttc  17760
tctaaagct  ggtttctgc  gaccagtag  aatttttaa  atcagtctg  tttccctct  17820
tcagcctat  ggctttgct  ggttatctc  cctgactaa  ttgtgtagc  acttcacat  17880
aatttaaac  tttgtatca  cagttaaca  tcactttga  aatgttatt  ggaggcttg  17940
taagtcagg  gtattttgt  tgactgctc  acactcagg  cttctggaa  ccctgcaga  18000
ggtagctct  gtggccagc  agctctctt  ctgaaaatg  gcaacataa  tacatgaaa  18060
acccaacaa  taggatttg  aagcggggc  aattgtacc  ttatttctt  tggggataa  18120
agtcttaaa  tttgtttaa  gtaaaatgt  tttatttct  acggtgatt  gtttcactt  18180
aatagcttg  tgtttgttt  tttcatttc  cttaagttt  gggttgggt  tggtttgtt  18240
cccgcaagt  ttgcccgtg  cgccttcct  cttgtgcct  cagggacat  tgctggtgt  18300
gcagcctcc  ggcccgtcc  cagcctttt  cttggcaca  cttctctag  atggctggg  18360
cagtgactt  gcttctaca  ctgtgacta  ccattttca  tccattcta  agctttgac  18420
attattctg  caatgttat  gtagatgga  aaccggtga  tctgggctt  tgggataca  18480
ctggacaag  agattatga  agattacgc  ccctatcct  tccgcaaac  gtaaggatt  18540
cagctgact  ttaatgtgt  ttttagagt  tataattct  gagcgctta  ttagtgcat  18600
ttacctatg  acttgctta  attgccatc  tttgggtat  gagtaaata  caaacaggg  18660
gggattggt  ccatgtaaa  atcccccta  atgcaagcc  aggggtttt  tgttttgag  18720
gttaccagc  gttccattg  tgggcattt  acagtcttc  atttagctt  agaataacc  18780
tatgaaaga  ctacttttt  tttttgcaa  ccagttttt  acaccaatt  gtttgaagg  18840
aggtttgct  tgtgacatt  ttgtaccac  gaatcaaat  aggcagtta  gattcaggt  18900
tctttaaac  aagttagta  ctaatctca  aggtttaat  cattttttc  cacaaaata  18960
ataatttgt  tggattttg  gaaccatac  atagaacct  aatttattc  atgtagatt  19020
aagttttgg  tttgtaaaa  gtatccact  tgtctaatc  gaaaaaaaa  tttactttt  19080
cttctgtat  agacaacta  gtgatttat  taccaaagc  aattagagc  gtagctggt  19140
aaaatgggt  cttagaaga  attgttgtc  ttaaaagtt  cttttcttt  agcagcggt  19200
ttacttgtg  atcatttgc  tatcttgtt  catgtttgt  cttcatttt  aaaagtatc  19260
ttggaagca  aagttaaat  tgcttgaga  tccttgggt  gataacctg  gtgcatgtc  19320
tagctctgt  acttcaggc  ggcttcatc  tctctccag  ctttgcctg  ttccttgta  19380
ggtgagatg  gtacgtgtc  cgcacgcat  acagtcctg  gcacatagc  cacactgtg  19440
ggccagccg  tgtcagaat  ctcctgttc  tcagtgtgc  ggtgggtcg  cctaaagag  19500
gctgctttc  acgttgtgc  caaatgagt  gaagttgtg  ggtgctcag  acacctggg  19560
tggccggag  gattggggt  ggggttggg  tgaggtcag  aagacatcc  agagaaagg  19620
tggctttga  ccctgattg  tgatgaggc  gcctgtgat  gattcaacc  gtacttcgt  19680
gtagggggt  atatgggtg  aataactta  tggttaagt  tgctgtatt  aaaatcagt  19740
tataatccc  agacaattc  aattcttca  tatcttagg  aactcttct  tacccagtg  19800
atgtttaat  attcagatt  taaatggat  taaaaacat  ctggctggt  gagtaggag  19860
cttcagccc  ctggacaca  gtggaaggg  gtggtgtca  tctgagaaa  aagagccac  19920
ctgctgtga  tcagggggt  ccgggcagg  tgaggcctc  ctaaggaag  cctcacagt  19980
agtcaaggg  gacttggca  gagtcccac  ttgtgttct  aggaacaca  agataagga  20040
agagaactc  cctcagctt  aacaaagct  tagagtgtg  cgcctggta  caaagtagg  20100
gttgtcctc  tagggctag  acttaaact  catgtttcc  ctgtgtgag  ctgtggact  20160
ctttcctat  aaatatttg  ggagcaagg  agggagtgg  acatggttc  tgccctcag  20220
tagttcaca  aaaagtccc  taaactgtg  aagacaccc  gtgctagca  gggggtgag  20280
cgggcgctt  aggagcaag  ggggcgagc  cccacccag  agtggaagc  ttcctgtct  20340
gactccttc  gagataagg  aattatctt  acaactcag  ggcaggcca  agatgctca  20400
ataccagtg  ctggaaggt  tcatccctt  gagccacac  gtcctaaga  gaactggat  20460
tggtagtaa  atgctggca  ctgggtctc  tgttgataa  ggggaaacc  ctaaatttt  20520
tactacatg  aatgtggtc  ctgattgct  gctctgtgg  ctgcagacc  gttgatgta  20580
ctcatccaa  actgcttag  cactctcct  aaggaccag  tggaagatt  cttatctag  20640
gtgtcctaa  aagagatgt  acatttctt  tggtcattt  acattggca  cctctctat  20700
gggcagctc  gtcggctaa  tctgttcag  ccattcatt  cttcttcgt  ctccaaaga  20760
ggtgagcag  tagtcgcca  tcttagttg  aattgccct  caggttttt  tttcccgaa  20820
tacgtaatc  ttacattat  ttctcttga  aatctttgc  aagttctgc  tactcatct  20880
cagttgcta  gcacagaat  aagtcttgt  agagtaacg  tcaagtcca  catcttccc  20940
tgtgtagat  acctgtatt  atttgcctg  ttgtaccag  attggtggt  tgagtggga  21000
cctaagtga  ctgtcagtg  cacagcgag  cctgagccc  gtgtgtgtc  tgagactca  21060
gctgtgcag  gggttcgct  agatgctga  cctccatgt  ggggtcagc  aggacccca  21120
tgcgtcatg  cagttgttt  attttctct  taggctaaa  gttgttgtt  ttgttgttg  21180
tgtttgaga  agagtttcg  tcttgttgc  aggctggag  gcaatgggt  tgatcttgg  21240
tcactgcaa  ctccgcttc  caggttcaa  tgactttcc  gccctagtc  ctcaagtag  21300
tgggactac  ggcatgtgc  accatgcct  gctaatttt  ttttgtatt  tattttttt  21360
gagacagag  gagactctg  ctcaaaaaa  aaaaagaaa  caaagaaaa  agaaaagct  21420
gagtgagat  aaattaaaa  aattttctc  ttttgagac  gggtctcgc  ctgtcaccc  21480
gactggagt  cagtgtcac  atctcgcct  actgcaacc  ccacctccc  ggttcaagc  21540
gttctctgc  tcagcctcc  gagtagctg  gattacagg  gcctgccac  atgcccggc  21600
aattttttg  atttttagt  gacacaggg  ttcaccatc  tggccaggt  ggccttgaa  21660
tcctgacct  gtgatccac  tgcctcggc  tcccaaggt  ttgggatta  aggcgtgag  21720
gcttttctt  aaagagttc  agggttcta  gttggaaga  cgagtttgt  agtttttat  21780
ggaacaaag  aatgaattg  cagcattgt  ataaacact  gaagtgtca  ttctaaaat  21840
tgtccatgg  tgaaagtgg  ggctcatgc  tgtaatccc  gcacgttgg  aagccaagg  21900
gggtggagc  cctgaggtc  agagtttga  accagcctg  ccaacatgg  gaaacctgg  21960
ctctactaa  aatacaaaa  attagctgg  cgtggtggt  tgtgcctgt  gtcccagct  22020
cttgggagg  taaggcagg  gaatcgctt  aacccagga  gcagaggtt  cagtgagct  22080
agatctcac  attgcactc  agcctgggc  acagagcaa  actccgtct  aaaaacgct  22140
gtccttaag  ggtggcttc  cccagacct  caaagtagc  cagaattgg  ggtcttagt  22200
tcagcaaca  tgctgattt  gataatgca  gtctgtaca  tcaaaccag  ctcccagaa  22260
taggtggaa  ataggaaca  ttctgcata  gagacttgg  atgttctgg  agcattaaa  22320
ccctgaggc  cggctatgt  ctgggagag  cctttggca  gcatcattt  cagacgggt  22380
cttttcctg  atgctgtgg  ttcaactag  ctgtgtctg  gaactcgga  ggagcactt  22440
aaagtgccc  tggctcccg  ctgcctttg  ggtaaggga  agtgcagaa  atctccggc  22500
gtgccagct  ttgtagatt  tggtgggtg  tgccatggg  ggaggagca  gttgttgcc  22560
cccctcagg  tctccctga  ctctgtctt  accatcgtt  aacttaacg  ctgcttttg  22620
ccaggtagc  tggagtgtt  cagtggcat  tgtcatcga  gatatgtta  aatctattg  22680
atgcttttg  atctctccg  agggttaag  caaaattct  ataaagaat  gataagagg  22740
tatattgat  tttgttgtc  tcagtctgt  ctaaactca  accaagttc  catgcatta  22800
taggttgga  aaacgtacg  taaggatat  acctcccgg  gcaaagaca  gccgattgc  22860
gtatgtaaa  ctttcagtc  acttcagtt  caagctttc  ctgttctct  atttcactt  22920
gttttccta  gatttttta  taagcctca  gctccttga  tgttttata  ttaattcac  22980
caaggttgg  gttttgctt  atgaaataa  cttcattag  gtgtgatag  ttacccacc  23040
gcttgaatt  aagcagttt  tgaactgtg  tcttctcct  ccaagtgaa  ggaggggac  23100
gtgagaggg  ccctctcct  gctggttgg  gatgcagat  tggagactc  tcccggaag  23160
ccacctggc  gtgagccga  ccggagcag  accaacctt  ttgccgggg  cttctttct  23220
cgcttgggt  tcccgtgtg  tggggctgt  tgggcgtgg  tgtgcagtg  tgctgagct  23280
accccaccg  gcttgagat  gtgtgctgg  tgccgcggt  attcttgga  gagcttgtg  23340
atgcgccag  actcttcaa  tgccagtta  aaaaagctg  tgtgtggga  gtttctttc  23400
ctttcaggt  caaggtatc  gctggaggg  tgaaagtgt  gcttgggaa  tgtgtgcat  23460
tcataaagt  gcataattg  ctttttcca  gagaatatt  tagaaatct  gcattttag  23520
attcttggg  atttttaaa  acaggtgaa  atttgaatt  ggtttgaca  aaaatacag  23580
atggatgaa  catgcagat  tttggcgtg  gccccgaag  accctctac  ctgtcctct  23640
cacccaccc  ttgcgcctc  gcgtcagcc  cagctgccc  gggagcgag  tctcctgag  23700
ccctggctg  gctgactct  gggcagcgt  agggtggtt  tcagctgtg  aggtgccac  23760
tacacacta  gtcctcctt  cttgtggag  gaagggctc  agtagcaaa  attggagcc  23820
ccgcttggt  ctgggagct  tgacaggca  ctcctgaag  agcagttta  ttggaacca  23880
tgaccatct  aaactgttt  tactctaaa  cagatttta  agaaatatt  gaatcatac  23940
tttatactt  attttttct  tttagatag  taggcgtaa  ggaagcctc  tgagggtct  24000
gtctgatcc  cctgatcct  gaagagctt  cagcatcat  ctcccttca  gctccccat  24060
ttcataagt  actggtggc  tgacatgct  ggtttggtt  gggagccct  tgacaaact  24120
aaagggtgg  tcaggaagc  tctgaccac  ccactggta  acacgctct  cgtccaaca  24180
gtccttccc  gcaacatgt  gaaagcaaa  tgcatgctt  attctaagg  tgttgtcta  24240
atgtttccc  gtgtttcct  tttgtagga  gtgttctta  tttgctttt  ccttgtgag  24300
cctgcatca  ttgaaaatg  ccgtgcaaa  gtaggtggg  atttaaaat  tgtatgtaa  24360
ttatagaat  atcctctca  aaataaata  tttaaaata  cacttagcc  aggaatttt  24420
agttattta  attggtttt  gcaatttgc  acttaggta  atgattggg  ttttttttt  24480
cttttgaga  ggaggtctc  ctctgttgt  tccaggctg  agttgtact  gtgacatca  24540
agctcactg  agccttgaa  tcctgggct  aaacagttc  cctgcccca  cctcctgag  24600
tgctgggac  ataaatgtg  accaccatg  gtggctaat  ttaaaagaa  ttttgtatg  24660
ctggttttg  agaccctgg  ttgtctcaa  ctcctgggt  gaagtgatc  ttcagcttc  24720
gcctcccaa  gtggtggga  tatagctgt  agccactgc  tctggccca  cagcagttt  24780
ttttattta  ttatttttg  gagagtctt  ttttttgct  ttgtttttg  ttttgagat  24840
gagtttcac  cttgttgcc  aggctggag  gcagtgacg  aatcttggc  cactgcaac  24900
tccgcctcc  gggttcaag  gattctcat  cctcagcct  ccgagtagc  gggattaca  24960
gcatgcacc  ccacgcccg  ctaattttg  atttttagt  gaaatgtgg  ttctccacg  25020
cagtcaggc  ggtctcgaa  tcccgacct  aggtgatcc  cgcgtctcg  cctcccaaa  25080
tgctgggat  acaggcgtg  gccaccgtg  ccggctgag  cagaatctt  cgctgtcat  25140
caagctgga  tgcagtggc  caatcttgg  tcactgcaa  ctccccctc  cggttcaag  25200
aattctcct  cctcagcct  cttagtagc  gggattaca  gtgcccgac  acacacctg  25260
ctaattttt  tacttttag  agagacggg  tttcaccat  tttgccagg  tggtctcga  25320
cccctggcc  caagtgatc  acccgccgc  gactcccag  gtgctggga  ttcaggtgt  25380
agccactat  cccggccta  tacgtggat  tttaaagct  caggttctg  ttcagaagt  25440
tcctgggtc  cattaaaat  atgaggcac  cagaattgg  ctaataaaa  taacgacca  25500
ttctttcta  tccagtctc  ttcacaaac  tcttagtga  aatgacaag  gaggccctt  25560
agtaggggc  ttttcagtg  agataatag  ggcagacct  agaccttgg  ctaggtagt  25620
tattctcat  tctgaacag  tgatgaatt  tctcagatg  ccctaagaa  ttgttttac  25680
aaaaacaaa  tgatctatt  gctttggga  gaactccct  ccttttgtt  ctcttccct  25740
ccccccctc  cctgcggtt  tagagcccg  tctgtccgg  cgtggttct  tccagccat  25800
atccgggag  cctagcttg  taatggaac  cctgagatg  tccttatgg  tcaaggctt  25860
aattgaagg  gggaaccac  tgaagcctc  gtggggagg  cttgcctga  gttaggtgt  25920
tggcatgag  gccgccggc  gggtgtgat  taggtgaag  acatctgta  aggagcgtg  25980
cacaacctc  gttccttct  cacatctag  ggtatcctg  ggtgcggca  cactgtccc  26040
acactccca  catcctagt  ggaactaaa  ttgatctta  ggatgataa  gacacgatc  26100
agaaactga  ggagaagaa  ctgactccc  tcacctatc  gcagggtct  gccatggct  26160
aggagattg  tatggaatc  tgtgttttt  ctcctcctt  tacctcttt  attgtagtg  26220
cagagactg  agtccagtc  gggaaagga  ggtgtgtgt  tcccactca  ggcctggtg  26280
actcttggg  aaccagctg  caaggccct  tgggtctta  cgtcagcgt  ggaaggtgg  26340
agcagggct  ggagccggc  gaaggcgcc  gggccccag  agctgcctc  cgctggtgg  26400
gtgatcaga  gagagtggg  tcgagtgta  attgccgtg  ggtcgtgtt  cctgtaggt  26460
ctgtaaaat  cctggagtg  tcggcgctc  cacagcgag  cctcaagac  gtgtttgac  26520
aagcgatcc  agcagtcct  tgcccgcct  ccgtgaaga  gaggaagag  aaatgcctg  26580
tgttgtaaa  gtctcagcc  ctcgttctt  gtcctgtcc  ttggaacct  tgtacgctt  26640
gctcaaaaa  aaacaaaaa  aaaaaacaa  aaaaaaaaa  aacggtgga  ccttcgcac  26700
caatgccaa  tttttgtta  agattaatt  ttccataaa  ccatttttt  aaccaatca  26760
taattttaa  gttttgttt  ttctaaatg  aagagttca  actcacatt  tattaaaat  26820
tagccctaa  atgacaagc  ttcttaaag  cttattttt  aaaagcgcc  cccccattc  26880
tgttcagat  aagagttgc  aaaatacct  ctgaactac  ctgcattgt  gtgccgaga  26940
caccgagca  tgaactttg  aaagacctt  gtctttgag  agacggtag  ttctgcagt  27000
aggaggtgc  gacacttgc  ctcctatgt  gttctcaga  gcgtaaagc  gaacagcct  27060
ccgaatgaa  cgttgccat  gaactcacc  gtgagttag  agcacgtgt  cccgacata  27120
cattgtact  taatggagt  agcgtagca  ctcagctct  tggatcagt  tttgtgatt  27180
catagcgag  tttctgacc  gcttttgcg  agattttga  cagaactgc  atttcctct  27240
atgaagaat  ctgtttagc  gtgggtgtg  cgggtgggg  gtgtgtgat  aaaggacaa  27300
gacagtatt  tgacaaaat  cgaagtgga  atttacact  cattgtaca  ggaatgaaa  27360
tgtcacggg  aaaaactct  aaaggttaa  ttctgtcaa  tgcagtaga  gatgaaaga  27420
aggttggta  tatcaggaa  tgttttctt  agcttttcc  ttctcttac  cctgccatg  27480
ctccccaaa  tgggcattt  attcatctt  aaactggtt  ttctgttag  cgctaactt  27540
gtaagtgct  ttcttatag  accccttct  actgagcaa  atgcctcct  gtattataa  27600
atctttctg  taatgcatt  gaaggtttt  ttgtcgatt  gtaaaagtg  tttccatgt  27660
actttattc  gagctaata  gtgctttcc  tagttttct  gtaactagg  gtaaaaatc  27720
tgtgttgca  ctttatagt  tttaaaata  tttagataa  tcttaaact  tgaaccttc  27780
taacatcac  gtcttgcca  attaccgac  ctgtcactt  accaatact  accctcttt  27840
cctcgccca  gcggacaca  gcctcctgt  gtcgctttg  ctattgatg  tcctttggg  27900
ctgtgaggt  ctgtaaact  tgctagtgc  gacgatgtt  tgtacaact  aactcactg  27960
cgagaatac  gcgtgggac  cttcagcca  tacaacaga  ttttttaaa  tgacagttg  28020
agaattgtg  agtgttttt  cattgatct  ttgctaatg  aattagcat  atgttttgc  28080
tgtatgact  aataaatcc  tgaatcata  gactggtaa  actggtgtt  ttgagactt  28140
atgaacaag  tcctggtgt  tgtttgttt  ccttgcttt  aagtcctgg  ttgttggag  28200
cagtcattt  caatgcgtg  ctccacaca  gagggacag  gagtgccac  tccagggga  28260
aactgggtg  gcccaaata  ggcaggagt  gaggtgaca  tcatgtttg  acctgtcga  28320
cagtggcga  gctctgagg  agaagcgcc  atcggggtg  gtgtgcaca  cctggccca  28380
agctagggg  tgaagatgg  gatgttggg  ccctagact  gccctggaa  agtagaggt  28440
ggtgaacca  atgccctta  gatcctttc  agaggctga  tgcgtggct  acgcctcta  28500
gcccgacgc  ttgggaggc  gacacagga  gagcgctta  gcccaggag  tctagacca  28560
cctggac  28567



<210> 4321
<211> 192
<212> PRT
<213> Homo sapiens
<308> CAA10733
<400> 4321

Met Gln Ala Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
  1               5                  10                  15
Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
             20                  25                  30
Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly 
         35                  40                  45
Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
     50                  55                  60
Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile 
 65                  70                  75                  80
Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys 
                 85                  90                  95
Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro Ile Ile Leu 
             100                105                110
Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Thr Ile Glu Lys 
         115                120                125
Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro Gln Gly Leu Ala 
     130                135                140
Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu Cys Ser Ala Leu 
 145                150                155                160
Thr Gln Arg Gly Leu Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val 
                 165                170                175
Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys Cys Leu Leu Leu 
             180                185                190



<210> 4322
<211> 623
<212> DNA
<213> Rattus norvegicus
<308> AA799550
<400> 4322

acttttatt  acatgtaag  ttttgtttt  aacatggta  gggttttga  ctcaaatgc  60
tatcaggtc  gccacacat  tatagcttg  ctacatatg  accttgaag  cgcctcttc  120
ttgaagttt  gggtccatt  caggttttc  ttctcagta  acaaagggt  ttgcaagga  180
ctttcattt  acgcccagg  tctcctcaa  tatatgggg  taccaactt  tacagacga  240
caagacctc  tctcccata  cgggttccg  ttcatttaa  aatgagtta  gctgtccca  300
caaactcat  aggcaggtt  taatagata  tgtagcaca  aaaatttaa  atttgcaca  360
aatacatct  tcctccttt  gtctcacac  gaaattaaa  tccccccat  gaaacaata  420
aatcctccg  cccttctcc  aggtcatca  tcctagccg  gtaaggccc  tccacagtc  480
cagatgaag  ctgggccct  cttctgcca  tgctgcatg  agtcctctt  tagaattaa  540
gcagcttcc  cagaacttt  agangcggt  agctccaac  ccaagtctc  agtgtcaca  600
ggggaccaa  ttcagggag  tag  623



<210> 4323
<211> 616
<212> DNA
<213> Rattus norvegicus
<308> AA799551
<400> 4323

cacgggtcc  ggccgccgg  gtggatcag  accctgagt  tttccgggg  gccccgcaa  60
gccgcagac  agatgaaca  tctggcccc  gtgcggagg  accgcgtcc  ggcggtcct  120
ccccagtgc  tgaagaagg  ggccgcttt  cacgtgcgc  tatacttcc  gccccgggt  180
acttgcgcc  gccagcagc  ccggacagg  accgtagga  ttaaaagat  caaggtcat  240
gttgtgggg  acctacctg  ggggaacac  tgtcttagt  ataggttct  caacgacac  300
ttccataag  attacaagg  taccatctg  gtggctttt  acatgcgaa  gattcgagt  360
ctgggtgtc  ccttcagtc  ccacctttg  gacactgct  gtcaggaga  gttcacgtg  420
atcgcatcc  cctactaca  aggagcaca  gccatcatc  ttgtcgtca  cctgaatga  480
gtagcatcc  tgttgcact  caagcagtg  ctcgctgat  ccctcaacg  caatgaccc  540
tctagagtg  ttctcgtcc  tgtgggttc  aagagagat  ggagtactc  tgcttcagt  600
ttccctaat  gagaac  616



<210> 4324
<211> 201
<212> PRT
<213> Rattus norvegicus
<308> S06147
<400> 4324

Met Asn Pro Glu Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp 
  1               5                  10                  15
Ser Gly Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala Asp Asp Thr 
             20                  25                  30
Tyr Thr Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe Lys Ile Arg 
         35                  40                  45
Thr Ile Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile Trp Asp Thr 
     50                  55                  60
Ala Gly Gln Glu Arg Phe Arg Thr Val Thr Ser Ser Tyr Tyr Arg Gly 
 65                  70                  75                  80
Ala His Gly Ile Ile Val Val Tyr Asp Val Thr Asp Gln Glu Ser Tyr 
                 85                  90                  95
Ala Asn Val Lys Gln Trp Leu Gln Glu Ile Asp Arg Tyr Ala Ser Glu 
             100                105                110
Asn Val Asn Lys Leu Leu Val Gly Asn Lys Ser Asp Leu Thr Thr Lys 
         115                120                125
Lys Val Val Asp Asn Thr Thr Ala Lys Glu Phe Ala Asp Ser Leu Gly 
     130                135                140
Val Pro Phe Leu Glu Thr Ser Ala Lys Asn Ala Thr Asn Val Glu Gln 
 145                150                155                160
Ala Phe Met Thr Met Ala Ala Glu Ile Lys Lys Arg Met Gly Pro Gly 
                 165                170                175
Ala Ala Ser Gly Gly Glu Arg Pro Asn Leu Lys Ile Asp Ser Thr Pro 
             180                185                190
Val Lys Ser Ala Ser Gly Gly Cys Cys 
         195                200



<210> 4326
<211> 259
<212> PRT
<213> Homo sapiens
<308> Q9BZG1
<400> 4326

Met Asn Ile Leu Ala Pro Val Arg Arg Asp Arg Val Leu Ala Glu Leu 
  1               5                  10                  15
Pro Gln Cys Leu Arg Lys Glu Ala Ala Leu His Gly His Lys Asp Phe 
             20                  25                  30
His Pro Arg Val Thr Cys Ala Cys Gln Glu His Arg Thr Gly Thr Val 
         35                  40                  45
Gly Phe Lys Ile Ser Lys Val Ile Val Val Gly Asp Leu Ser Val Gly 
     50                  55                  60
Lys Thr Cys Leu Ile Asn Arg Phe Cys Lys Asp Thr Phe Asp Lys Asn 
 65                  70                  75                  80
Tyr Lys Ala Thr Ile Gly Val Asp Phe Glu Met Glu Arg Phe Glu Val 
                 85                  90                  95
Leu Gly Ile Pro Phe Ser Leu Gln Leu Trp Asp Thr Ala Gly Gln Glu 
             100                105                110
Arg Phe Lys Cys Ile Ala Ser Thr Tyr Tyr Arg Gly Ala Gln Ala Ile 
         115                120                125
Ile Ile Val Phe Asn Leu Asn Asp Val Ala Ser Leu Glu His Thr Lys 
     130                135                140
Gln Trp Leu Ala Asp Ala Leu Lys Glu Asn Asp Pro Ser Ser Val Leu 
 145                150                155                160
Leu Phe Leu Val Gly Ser Lys Lys Asp Leu Ser Thr Pro Ala Gln Tyr 
                 165                170                175
Ala Leu Met Glu Lys Asp Ala Leu Gln Val Ala Gln Glu Met Lys Ala 
             180                185                190
Glu Tyr Trp Ala Val Ser Ser Leu Thr Gly Glu Asn Val Arg Glu Phe 
         195                200                205
Phe Phe Arg Val Ala Ala Leu Thr Phe Glu Ala Asn Val Leu Ala Glu 
     210                215                220
Leu Glu Lys Ser Gly Ala Arg Arg Ile Gly Asp Val Val Arg Ile Asn 
 225                230                235                240
Ser Asp Asp Ser Asn Leu Tyr Leu Thr Ala Ser Lys Lys Lys Pro Thr 
                 245                250                255
Cys Cys Pro 
             260



<210> 4327
<211> 604
<212> DNA
<213> Rattus norvegicus
<308> AA799560
<400> 4327

cacagcaga  gttgtgtga  acaggaggt  acaccctac  cacaagagt  tggtcagag  60
ctgaggtag  ccttcccac  ctgatgcca  accccaagc  gtcggacct  agttctttc  120
cccagtccc  ctttaggtg  acactgaca  ctattaaag  tagtgcggc  aaaggaccc  180
ggcccctcc  taatgcccc  gcttcaatg  gtttaccat  gttcttcac  ggccaccat  240
tcccgttct  actttcttt  tacatgctg  atatgtcta  cacgttaag  atcagtaac  300
caccagcaa  tattcccct  agagacatc  atttaggag  attgccttc  gaggcctta  360
acgtcaagg  actgtgtca  ctttggggg  atggagctc  tcatatccc  ccaccaacc  420
tacacatac  cacactctc  tacccttgc  aatatgggc  aaagagggg  agtgatggc  480
tccccgtga  agctaaaac  acttattgt  cctcaccta  agaaacaag  cagagaggg  540
acataaaag  cttcccagg  caaaacggg  gaggagata  ttagggggc  ggatcctaa  600
aata  604



<210> 4328
<211> 2016
<212> DNA
<213> Homo sapiens
<308> AK057843
<400> 4328

gcgggaagc  cgagccggg  cgggcccga  tcaaaggca  gtgaaggtg  aagcggccg  60
ggcggcagc  ggccaccat  gcggagctg  aggaggtgc  gatcacaga  gagaagcca  120
tgttgccag  acagacgcc  gaggcggcc  aggaggctg  gttagctgc  cgaatcctc  180
tggaccagg  acagactca  tctgtggag  caccatacg  ctctgtcac  ttcactgtc  240
atggcaccc  caaacccaa  cgcccagcg  tccttacct  ccacgatgt  ggactcaac  300
ataaatctt  cttccagcc  ctgtttcag  tcgaggaca  gcaggaaat  attcagaac  360
ttgtgcggg  tcatgtgga  gcccctgga  tggaagagg  agcccctgt  ttccctttg  420
gatatcagt  cccatctct  gaccagctt  cagacatga  cccttgcgt  ctgcagtac  480
taaatttct  tacaataat  ggagttggt  ttggagctg  agcctacat  ctggcgaga  540
atgctctta  ccacccgga  actgttgaa  gtcttgtcc  catcaacat  gatcccaat  600
ccaagggtt  gatggattg  gcagcccac  agctaacag  cctcacctc  tccattccg  660
agatgatcc  tggacatct  ttcagccag  aagagctct  tggaaattc  gagttgata  720
aaaagtaca  aaatatcat  acacatgca  ccaacctgg  taacattga  ttgtactgg  780
acagctaca  caaccgccg  gacctgaac  ttgagcgtg  aggtgatat  accctcagg  840
gtcctgtga  gctggtggt  ggagaccaa  cacctcatg  agatgcagt  gtggaatgt  900
actcaaaac  ggaccccac  cagacctcg  tcctcaaga  ggctgactc  ggaggtcag  960
cccagctga  tcagccagg  aagctgacc  aggccttca  gtacttcct  caaggcatg  1020
gctacatgg  ctcatcctg  atgactcgc  tgtcccggt  tcgtacagc  tctctgacc  1080
gtgcagcat  cgttgatgg  aaccggtcc  gctctcgca  cctgtccca  agcagcgag  1140
ctggaactc  ttcttcggg  cccccgggg  acaccatgg  ggtctcctg  tgaatggcc  1200
ttgttgccc  agagtggga  ccagccctc  cctccccca  agctaacct  ggaggtgct  1260
aaggggcat  gggccaccg  aagcaaggg  aaaagggca  atcatgcgg  gagatgacc  1320
tgatctttg  ttgctaccc  aaccttgac  tttaacccg  gattccccc  agctcctgg  1380
agagatgtc  taatatctc  tagggaccc  gacccctaa  ttctcctcc  cccccattt  1440
ggtgttaag  tggagaggg  atatgcatc  tctgtcctg  tctaggtgt  tatagctga  1500
gggtaagag  ttgttgtag  tgtcctggt  cctccatca  actctccct  cttgtccca  1560
atttgcaag  ggaggggat  tggggctgg  gctccattc  ccaaagctg  ggtggcttc  1620
cattaaccc  ttaggactc  gaagggtat  gacctacgt  aatgtgtgt  agggggaga  1680
ttgctggtg  gttagtggt  ctcaggatg  gatagaaac  tccagtgta  aaaggaagt  1740
ggaatggga  ttggcgggc  gtgaacgag  gtggggaag  attggtgct  gggcaacag  1800
aaggggcct  gggccgttt  gctgcacta  ctttggtag  tcagtgtgc  tctagagtg  1860
gactgggga  ggagctaag  ttgggctgg  ctgcttggg  cttggcata  ggtggaaag  1920
gctaccctg  ggctctgac  acactgtag  atgtgtgga  ggtgccctc  cgtctccca  1980
aacttctgc  ataacaata  actgtagag  aatctg  2016



<210> 4329
<211> 371
<212> PRT
<213> Homo sapiens
<308> Q9UN36
<400> 4329

Met Ala Glu Leu Gln Glu Val Gln Ile Thr Glu Glu Lys Pro Leu Leu 
  1               5                  10                  15
Pro Gly Gln Thr Pro Glu Ala Ala Lys Glu Ala Glu Leu Ala Ala Arg 
             20                  25                  30
Ile Leu Leu Asp Gln Gly Gln Thr His Ser Val Glu Thr Pro Tyr Gly 
         35                  40                  45
Ser Val Thr Phe Thr Val Tyr Gly Thr Pro Lys Pro Lys Arg Pro Ala 
     50                  55                  60
Ile Leu Thr Tyr His Asp Val Gly Leu Asn Tyr Lys Ser Cys Phe Gln 
 65                  70                  75                  80
Pro Leu Phe Gln Phe Glu Asp Met Gln Glu Ile Ile Gln Asn Phe Val 
                 85                  90                  95
Arg Val His Val Asp Ala Pro Gly Met Glu Glu Gly Ala Pro Val Phe 
             100                105                110
Pro Leu Gly Tyr Gln Tyr Pro Ser Leu Asp Gln Leu Ala Asp Met Ile 
         115                120                125
Pro Cys Val Leu Gln Tyr Leu Asn Phe Ser Thr Ile Ile Gly Val Gly 
     130                135                140
Val Gly Ala Gly Ala Tyr Ile Leu Ala Arg Tyr Ala Leu Asn His Pro 
 145                150                155                160
Asp Thr Val Glu Gly Leu Val Leu Ile Asn Ile Asp Pro Asn Ala Lys 
                 165                170                175
Gly Trp Met Asp Trp Ala Ala His Lys Leu Thr Gly Leu Thr Ser Ser 
             180                185                190
Ile Pro Glu Met Ile Leu Gly His Leu Phe Ser Gln Glu Glu Leu Ser 
         195                200                205
Gly Asn Ser Glu Leu Ile Gln Lys Tyr Arg Asn Ile Ile Thr His Ala 
     210                215                220
Pro Asn Leu Asp Asn Ile Glu Leu Tyr Trp Asn Ser Tyr Asn Asn Arg 
 225                230                235                240
Arg Asp Leu Asn Phe Glu Arg Gly Gly Asp Ile Thr Leu Arg Cys Pro 
                 245                250                255
Val Met Leu Val Val Gly Asp Gln Ala Pro His Glu Asp Ala Val Val 
             260                265                270
Glu Cys Asn Ser Lys Leu Asp Pro Thr Gln Thr Ser Phe Leu Lys Met 
         275                280                285
Ala Asp Ser Gly Gly Gln Pro Gln Leu Thr Gln Pro Gly Lys Leu Thr 
     290                295                300
Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr Met Ala Ser Ser 
 305                310                315                320
Cys Met Thr Arg Leu Ser Arg Ser Arg Thr Ala Ser Leu Thr Ser Ala 
                 325                330                335
Ala Ser Val Asp Gly Asn Arg Ser Arg Ser Arg Thr Leu Ser Gln Ser 
             340                345                350
Ser Glu Ser Gly Thr Leu Ser Ser Gly Pro Pro Gly His Thr Met Glu 
         355                360                365
Val Ser Cys 
     370



<210> 4330
<211> 595
<212> DNA
<213> Rattus norvegicus
<308> AA799566
<400> 4330

gcccattac  aaagtcttt  ttcgctggc  ggtgcattc  tgtaacaca  atccctagt  60
ctcaaggtc  cactcaact  gattggccc  tcagcagca  agccacgta  tgtcctgat  120
ggacacagg  gagcccaag  tcttttcct  aaatacaag  ctcagtctc  tcaacaatc  180
attagaaat  atggctctt  gaaaagagt  ttgcacagc  atgcaggag  ggcccagca  240
ttgtactgc  tccatgggc  ggcaggcca  tgggtggtc  tgccttgtg  gatggctca  300
tattagtac  tgcgggtta  attgtcagg  gggtttagg  gaggaccaa  ggctcagct  360
ccagggctc  ccagtagga  ccattctcc  cttgctgac  ctgcttcct  gcgcacaag  420
ctcttcttg  catccagag  cttggctaa  gctcggatc  cctgagatt  gaatggcag  480
aacacagaa  tggggtacc  agtgagagc  tgcatacac  gcagagcag  aatccggac  540
gccattgaa  gactggaac  gaaggtcag  agtttcgtg  caagttatc  catga  595



<210> 4331
<211> 1031
<212> PRT
<213> Rattus norvegicus
<308> AAK52670
<400> 4331

Met Ala Ala Ala Thr Gly Leu Glu Glu Ala Val Ala Pro Met Gly Ala 
  1               5                  10                  15
Leu Cys Gly Leu Val Gln Asp Phe Val Met Gly Gln Gln Glu Gly Pro 
             20                  25                  30
Ala Asp Gln Val Ala Ala Asp Val Lys Ser Gly Gly Tyr Thr Val Leu 
         35                  40                  45
Gln Val Val Glu Ala Leu Gly Ser Ser Leu Glu Asn Ala Glu Pro Arg 
     50                  55                  60
Thr Arg Ala Arg Gly Ala Gln Leu Leu Ser Gln Val Leu Leu Gln Cys 
 65                  70                  75                  80
His Ser Leu Leu Ser Glu Lys Glu Val Val His Leu Ile Leu Phe Tyr 
                 85                  90                  95
Glu Asn Arg Leu Lys Asp His His Leu Val Val Pro Ser Val Leu Gln 
             100                105                110
Gly Leu Arg Ala Leu Ser Met Ser Val Ala Leu Pro Pro Gly Leu Ala 
         115                120                125
Val Ser Val Leu Lys Ala Ile Phe Gln Glu Val His Val Gln Ser Leu 
     130                135                140
Leu Gln Val Asp Arg His Thr Val Phe Ser Ile Ile Thr Asn Phe Met 
 145                150                155                160
Arg Ser Arg Glu Glu Glu Leu Lys Gly Leu Gly Ala Asp Phe Thr Phe 
                 165                170                175
Gly Phe Ile Gln Val Met Asp Gly Glu Lys Asp Pro Arg Asn Leu Leu 
             180                185                190
Leu Ala Phe Arg Ile Val His Asp Leu Ile Ser Lys Asp Tyr Ser Leu 
         195                200                205
Gly Pro Phe Val Glu Glu Leu Phe Glu Val Thr Ser Cys Tyr Phe Pro 
     210                215                220
Ile Asp Phe Thr Pro Pro Pro Asn Asp Pro Tyr Gly Val Gln Arg Glu 
 225                230                235                240
Asp Leu Ile Leu Ser Leu Arg Ala Val Leu Ala Ser Thr Pro Arg Phe 
                 245                250                255
Ala Glu Phe Leu Leu Pro Leu Leu Ile Glu Lys Val Asp Ser Glu Ile 
             260                265                270
Leu Ser Ala Lys Leu Asp Ser Leu Gln Thr Leu Asn Ala Cys Cys Ala 
         275                280                285
Val Tyr Gly Gln Lys Glu Leu Lys Asp Phe Leu Pro Ser Leu Trp Ala 
     290                295                300
Ser Ile Arg Arg Glu Val Phe Gln Thr Ala Ser Glu Arg Val Glu Ala 
 305                310                315                320
Glu Gly Leu Ala Ala Leu His Ser Leu Thr Ala Cys Leu Ser Cys Ser 
                 325                330                335
Val Leu Arg Ala Asp Ala Glu Asp Leu Leu Gly Ser Phe Leu Ser Asn 
             340                345                350
Ile Leu Gln Asp Cys Arg His His Leu Cys Glu Pro Asp Met Lys Leu 
         355                360                365
Val Trp Pro Ser Ala Lys Leu Leu Gln Ala Ala Ala Gly Ala Ser Ala 
     370                375                380
Arg Ala Cys Glu His Leu Thr Ser Asn Val Leu Pro Leu Leu Leu Glu 
 385                390                395                400
Gln Phe His Lys His Ser Gln Ser Asn Gln Arg Arg Thr Ile Leu Glu 
                 405                410                415
Met Ile Leu Gly Phe Leu Lys Leu Gln Gln Lys Trp Ser Tyr Glu Asp 
             420                425                430
Arg Asp Glu Arg Pro Leu Ser Ser Phe Lys Asp Gln Leu Cys Ser Leu 
         435                440                445
Val Phe Met Ala Leu Thr Asp Pro Ser Thr Gln Leu Gln Leu Val Gly 
     450                455                460
Ile Arg Thr Leu Thr Val Leu Gly Ala Gln Pro Gly Leu Leu Ser Ala 
 465                470                475                480
Glu Asp Leu Glu Leu Ala Val Gly His Leu Tyr Arg Leu Thr Phe Leu 
                 485                490                495
Glu Glu Asp Ser Gln Ser Cys Arg Val Ala Ala Leu Glu Ala Ser Gly 
             500                505                510
Thr Leu Ala Thr Leu Tyr Pro Gly Ala Phe Ser Arg His Leu Leu Pro 
         515                520                525
Lys Leu Ala Glu Glu Leu His Lys Gly Glu Ser Asp Val Ala Arg Ala 
     530                535                540
Asp Gly Pro Thr Lys Cys Ser Arg His Phe Arg Cys Leu Gln Ala Leu 
 545                550                555                560
Ser Ala Val Ser Thr His Pro Ser Ile Val Lys Glu Thr Leu Pro Leu 
                 565                570                575
Leu Leu Gln His Leu Cys Gln Ala Asn Lys Gly Asn Met Val Thr Glu 
             580                585                590
Ser Ser Glu Val Val Ala Val Cys Gln Ser Leu Gln Gln Val Ala Glu 
         595                600                605
Lys Cys Gln Gln Asp Pro Glu Ser Tyr Trp Tyr Phe His Lys Thr Ala 
     610                615                620
Val Pro Cys Leu Phe Ala Leu Ala Val Gln Ala Ser Met Pro Glu Lys 
 625                630                635                640
Glu Ser Ser Val Leu Arg Lys Val Leu Leu Glu Asp Glu Val Leu Ala 
                 645                650                655
Ala Leu Ala Ser Val Ile Gly Thr Ala Thr Thr His Leu Ser Pro Glu 
             660                665                670
Leu Ala Ala Gln Ser Val Thr Cys Val Val Pro Leu Phe Leu Asp Gly 
         675                680                685
Asn Thr Ser Phe Leu Pro Glu Asn Ser Phe Pro Asp Gln Phe Gln Pro 
     690                695                700
Phe Gln Asp Gly Ser Ser Gly Gln Arg Arg Leu Val Ala Leu Leu Thr 
 705                710                715                720
Ala Phe Val Cys Ser Leu Pro Arg Asn Val Glu Ile Pro Gln Leu Asn 
                 725                730                735
Arg Leu Met Arg Glu Leu Leu Lys Gln Ser Cys Gly His Ser Cys Pro 
             740                745                750
Phe Ser Ser Thr Ala Ala Thr Lys Cys Phe Ala Gly Leu Leu Asn Lys 
         755                760                765
Gln Pro Pro Gly Gln Gln Leu Glu Glu Phe Leu Gln Leu Ala Val Gly 
     770                775                780
Thr Val Glu Ala Gly Leu Ala Ser Glu Ser Ser Arg Asp Gln Ala Phe 
 785                790                795                800
Thr Leu Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro 
                 805                810                815
Leu Ser Ala Cys Leu Thr Thr Arg Leu Met Gly Leu Leu Ser Asp Pro 
             820                825                830
Glu Leu Gly Cys Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp 
         835                840                845
Cys Thr Asp Val Leu Thr Arg Ala Gly His Ala Asp Val Arg Ile Met 
     850                855                860
Phe Arg Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly 
 865                870                875                880
Phe His Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu 
                 885                890                895
Ser His Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu 
             900                905                910
Pro Thr Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Ser 
         915                920                925
Val Val Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu 
     930                935                940
Ala Pro Gln Ile Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe 
 945                950                955                960
Leu Asn Leu Ser Ser Ser Tyr Ser Met Ala Val Arg Ile Ala Ala Leu 
                 965                970                975
Gln Cys Met His Ala Leu Thr Arg Leu Pro Thr Ser Val Leu Leu Pro 
             980                985                990
Tyr Lys Ser Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys 
         995                1000                1005
Lys Arg Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe 
     1010                1015                1020
Leu Leu Gly Ser Pro Gly Ser 
 1025                1030



<210> 4332
<211> 2181
<212> DNA
<213> Homo sapiens
<308> AK025496
<400> 4332

aatggagct  tgaagacaa  gatcaaagg  ctctgaatg  cttcaagga  cagctgtgc  60
cactggtat  catggctct  acagacccc  gcacccagc  tcagcttgt  ggcatccgt  120
cactgacag  cttgggtgc  cagccagat  tcctatctt  tgaggactt  gagctggca  180
tgggtcacc  gtacagact  agcttcctg  aggaggatt  ccagagttg  agggtggca  240
cactggaag  atcaggaac  ctggctgct  tctaccctg  ggccttcag  agccacctc  300
tacccaagc  cgctgagga  ctgcgtgta  gggagtcaa  tttgactaa  ggagatgag  360
ccacccaat  ctcccggca  ctgtgctgt  tgcaagcct  gtcagctgt  tcaacacat  420
ccagcatcg  caaggagac  ctgcctctg  tgctgcagc  tctctggca  gtgaacaga  480
ggaatatgg  tgcacaatc  agtgacgtt  ttgctgtct  tcagagcct  agacagatg  540
cagaaaaat  tcagcagga  cctgagagt  gctggtatt  ccaccagac  gctatacct  600
gcctgcttg  cttggctgt  caggcctct  tgccagaga  ggagccctc  gttctgaga  660
aagtactat  ggaggatga  gtgttggct  ccatggtgt  tgtcattgg  actgctaca  720
cccacctga  ccctgagtt  gctgcccag  gtgtgacac  cattgtgcc  ctcttcttg  780
atggcaacg  gtcctttct  cctgaaaac  gcttcccga  cagattcca  ccattccag  840
atggctcct  agggcagag  cggctgatt  cactgctta  ggcctttgt  tgctccctg  900
ctcgaaatg  ggaaatccc  cagctgaac  aactcatgc  ggagctttt  gaactgagc  960
gctgccaca  ctgcccctt  tcttccacc  ctgctgcca  gtgctttgc  ggactcctc  1020
acaagcacc  tgcagggca  cagctggat  aattcctac  gctagctgt  gacaaagtg  1080
aggctggcc  gggctctgg  ccctgtcgt  gtcaggcct  cactcttct  ctctgggta  1140
taaaggccc  agtgctcag  taccatcct  tcagctcct  ccttacagc  cggctcatg  1200
gcctcctga  tgacccaga  ttaggtcca  cagcagctg  tggcttctc  ctgctcatg  1260
ctgactgca  tgatgtgct  actcgtgct  gccatgctg  agtgcggat  atgttccgc  1320
agcggttct  cacagataa  gtgcctgct  tggtccagg  cttccatgc  gctccccaa  1380
atgtgaagc  aaactactt  aagggtctt  ctcatgtac  taacaggct  cccaagcct  1440
tactcttgc  agagctgcc  acggccctg  cctgccctg  ctgtgtggt  cagctctcc  1500
ccctcagct  ccttcagcc  cttctactg  aagcacccc  agtcatgag  cttcacgtg  1560
acaccctcg  caccaagtt  ctgaacctc  gctctagcc  ttccatggc  gtccggatc  1620
ccgcactgc  gtgcatgca  gctctcact  gcctgccca  ccctgtgct  ctgccgtac  1680
aaccacagg  gattcgggc  ttagccaaa  ccctggatg  caagaagag  ctggtgcgc  1740
aggaagcag  gtcagccag  ggggagtgg  ttctgttgg  gagccctgg  agctgagcc  1800
tcagtcctg  cctagactg  tctgacaat  taacctggg  ttactaact  ttgagccat  1860
ttccccaaa  cagggaaac  actggtctc  gactgcctt  cccacagac  cagcacaaa  1920
gctaggcct  tgttgcatg  ctgtacaaa  aacataaga  tccatattt  tagtggatt  1980
gtaaaataa  tgtgtgtga  acacttgcg  ttgaagaaa  atctagggt  ctgggtctc  2040
tgcatttat  tgtcagaaa  ggggcgata  gctgctgag  ggtgagtgc  tatgagtgt  2100
gccctgagg  ccagggctg  cagatgttg  ctacctgct  aagaataaa  atttctttt  2160
gtaaaaaaa  aaaaaaaaa  a  2181



<210> 4333
<211> 293
<212> PRT
<213> Homo sapiens
<308> BC009396
<400> 4333

Met Arg Glu Leu Leu Glu Leu Ser Cys Cys His Ser Cys Pro Phe Ser 
  1               5                  10                  15
Ser Thr Ala Ala Ala Lys Cys Phe Ala Gly Leu Leu Asn Lys His Pro 
             20                  25                  30
Ala Gly Gln Gln Leu Asp Glu Phe Leu Gln Leu Ala Val Asp Lys Val 
         35                  40                  45
Glu Ala Gly Leu Gly Ser Gly Pro Cys Arg Ser Gln Ala Phe Thr Leu 
     50                  55                  60
Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro Leu Ser 
 65                  70                  75                  80
Ser Cys Leu Thr Ala Arg Leu Met Gly Leu Leu Ser Asp Pro Glu Leu 
                 85                  90                  95
Gly Pro Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp Cys Thr 
             100                105                110
Asp Val Leu Thr Arg Ala Gly His Ala Glu Val Arg Ile Met Phe Arg 
         115                120                125
Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly Phe His 
     130                135                140
Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu Ser His 
 145                150                155                160
Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu Pro Thr 
                 165                170                175
Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Cys Val Val 
             180                185                190
Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu Ala Pro 
         195                200                205
Gln Val Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe Leu Asn 
     210                215                220
Leu Ser Ser Ser Pro Ser Met Ala Val Arg Ile Ala Ala Leu Gln Cys 
 225                230                235                240
Met His Ala Leu Thr Arg Leu Pro Thr Pro Val Leu Leu Pro Tyr Lys 
                 245                250                255
Pro Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys Lys Arg 
             260                265                270
Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe Leu Leu 
         275                280                285
Gly Ser Pro Gly Ser 
     290



<210> 4334
<211> 595
<212> DNA
<213> Rattus norvegicus
<308> AA799566
<400> 4334

gcccattac  aaagtcttt  ttcgctggc  ggtgcattc  tgtaacaca  atccctagt  60
ctcaaggtc  cactcaact  gattggccc  tcagcagca  agccacgta  tgtcctgat  120
ggacacagg  gagcccaag  tcttttcct  aaatacaag  ctcagtctc  tcaacaatc  180
attagaaat  atggctctt  gaaaagagt  ttgcacagc  atgcaggag  ggcccagca  240
ttgtactgc  tccatgggc  ggcaggcca  tgggtggtc  tgccttgtg  gatggctca  300
tattagtac  tgcgggtta  attgtcagg  gggtttagg  gaggaccaa  ggctcagct  360
ccagggctc  ccagtagga  ccattctcc  cttgctgac  ctgcttcct  gcgcacaag  420
ctcttcttg  catccagag  cttggctaa  gctcggatc  cctgagatt  gaatggcag  480
aacacagaa  tggggtacc  agtgagagc  tgcatacac  gcagagcag  aatccggac  540
gccattgaa  gactggaac  gaaggtcag  agtttcgtg  caagttatc  catga  595



<210> 4335
<211> 1031
<212> PRT
<213> Rattus norvegicus
<308> AAK52670
<400> 4335

Met Ala Ala Ala Thr Gly Leu Glu Glu Ala Val Ala Pro Met Gly Ala 
  1               5                  10                  15
Leu Cys Gly Leu Val Gln Asp Phe Val Met Gly Gln Gln Glu Gly Pro 
             20                  25                  30
Ala Asp Gln Val Ala Ala Asp Val Lys Ser Gly Gly Tyr Thr Val Leu 
         35                  40                  45
Gln Val Val Glu Ala Leu Gly Ser Ser Leu Glu Asn Ala Glu Pro Arg 
     50                  55                  60
Thr Arg Ala Arg Gly Ala Gln Leu Leu Ser Gln Val Leu Leu Gln Cys 
 65                  70                  75                  80
His Ser Leu Leu Ser Glu Lys Glu Val Val His Leu Ile Leu Phe Tyr 
                 85                  90                  95
Glu Asn Arg Leu Lys Asp His His Leu Val Val Pro Ser Val Leu Gln 
             100                105                110
Gly Leu Arg Ala Leu Ser Met Ser Val Ala Leu Pro Pro Gly Leu Ala 
         115                120                125
Val Ser Val Leu Lys Ala Ile Phe Gln Glu Val His Val Gln Ser Leu 
     130                135                140
Leu Gln Val Asp Arg His Thr Val Phe Ser Ile Ile Thr Asn Phe Met 
 145                150                155                160
Arg Ser Arg Glu Glu Glu Leu Lys Gly Leu Gly Ala Asp Phe Thr Phe 
                 165                170                175
Gly Phe Ile Gln Val Met Asp Gly Glu Lys Asp Pro Arg Asn Leu Leu 
             180                185                190
Leu Ala Phe Arg Ile Val His Asp Leu Ile Ser Lys Asp Tyr Ser Leu 
         195                200                205
Gly Pro Phe Val Glu Glu Leu Phe Glu Val Thr Ser Cys Tyr Phe Pro 
     210                215                220
Ile Asp Phe Thr Pro Pro Pro Asn Asp Pro Tyr Gly Val Gln Arg Glu 
 225                230                235                240
Asp Leu Ile Leu Ser Leu Arg Ala Val Leu Ala Ser Thr Pro Arg Phe 
                 245                250                255
Ala Glu Phe Leu Leu Pro Leu Leu Ile Glu Lys Val Asp Ser Glu Ile 
             260                265                270
Leu Ser Ala Lys Leu Asp Ser Leu Gln Thr Leu Asn Ala Cys Cys Ala 
         275                280                285
Val Tyr Gly Gln Lys Glu Leu Lys Asp Phe Leu Pro Ser Leu Trp Ala 
     290                295                300
Ser Ile Arg Arg Glu Val Phe Gln Thr Ala Ser Glu Arg Val Glu Ala 
 305                310                315                320
Glu Gly Leu Ala Ala Leu His Ser Leu Thr Ala Cys Leu Ser Cys Ser 
                 325                330                335
Val Leu Arg Ala Asp Ala Glu Asp Leu Leu Gly Ser Phe Leu Ser Asn 
             340                345                350
Ile Leu Gln Asp Cys Arg His His Leu Cys Glu Pro Asp Met Lys Leu 
         355                360                365
Val Trp Pro Ser Ala Lys Leu Leu Gln Ala Ala Ala Gly Ala Ser Ala 
     370                375                380
Arg Ala Cys Glu His Leu Thr Ser Asn Val Leu Pro Leu Leu Leu Glu 
 385                390                395                400
Gln Phe His Lys His Ser Gln Ser Asn Gln Arg Arg Thr Ile Leu Glu 
                 405                410                415
Met Ile Leu Gly Phe Leu Lys Leu Gln Gln Lys Trp Ser Tyr Glu Asp 
             420                425                430
Arg Asp Glu Arg Pro Leu Ser Ser Phe Lys Asp Gln Leu Cys Ser Leu 
         435                440                445
Val Phe Met Ala Leu Thr Asp Pro Ser Thr Gln Leu Gln Leu Val Gly 
     450                455                460
Ile Arg Thr Leu Thr Val Leu Gly Ala Gln Pro Gly Leu Leu Ser Ala 
 465                470                475                480
Glu Asp Leu Glu Leu Ala Val Gly His Leu Tyr Arg Leu Thr Phe Leu 
                 485                490                495
Glu Glu Asp Ser Gln Ser Cys Arg Val Ala Ala Leu Glu Ala Ser Gly 
             500                505                510
Thr Leu Ala Thr Leu Tyr Pro Gly Ala Phe Ser Arg His Leu Leu Pro 
         515                520                525
Lys Leu Ala Glu Glu Leu His Lys Gly Glu Ser Asp Val Ala Arg Ala 
     530                535                540
Asp Gly Pro Thr Lys Cys Ser Arg His Phe Arg Cys Leu Gln Ala Leu 
 545                550                555                560
Ser Ala Val Ser Thr His Pro Ser Ile Val Lys Glu Thr Leu Pro Leu 
                 565                570                575
Leu Leu Gln His Leu Cys Gln Ala Asn Lys Gly Asn Met Val Thr Glu 
             580                585                590
Ser Ser Glu Val Val Ala Val Cys Gln Ser Leu Gln Gln Val Ala Glu 
         595                600                605
Lys Cys Gln Gln Asp Pro Glu Ser Tyr Trp Tyr Phe His Lys Thr Ala 
     610                615                620
Val Pro Cys Leu Phe Ala Leu Ala Val Gln Ala Ser Met Pro Glu Lys 
 625                630                635                640
Glu Ser Ser Val Leu Arg Lys Val Leu Leu Glu Asp Glu Val Leu Ala 
                 645                650                655
Ala Leu Ala Ser Val Ile Gly Thr Ala Thr Thr His Leu Ser Pro Glu 
             660                665                670
Leu Ala Ala Gln Ser Val Thr Cys Val Val Pro Leu Phe Leu Asp Gly 
         675                680                685
Asn Thr Ser Phe Leu Pro Glu Asn Ser Phe Pro Asp Gln Phe Gln Pro 
     690                695                700
Phe Gln Asp Gly Ser Ser Gly Gln Arg Arg Leu Val Ala Leu Leu Thr 
 705                710                715                720
Ala Phe Val Cys Ser Leu Pro Arg Asn Val Glu Ile Pro Gln Leu Asn 
                 725                730                735
Arg Leu Met Arg Glu Leu Leu Lys Gln Ser Cys Gly His Ser Cys Pro 
             740                745                750
Phe Ser Ser Thr Ala Ala Thr Lys Cys Phe Ala Gly Leu Leu Asn Lys 
         755                760                765
Gln Pro Pro Gly Gln Gln Leu Glu Glu Phe Leu Gln Leu Ala Val Gly 
     770                775                780
Thr Val Glu Ala Gly Leu Ala Ser Glu Ser Ser Arg Asp Gln Ala Phe 
 785                790                795                800
Thr Leu Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro 
                 805                810                815
Leu Ser Ala Cys Leu Thr Thr Arg Leu Met Gly Leu Leu Ser Asp Pro 
             820                825                830
Glu Leu Gly Cys Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp 
         835                840                845
Cys Thr Asp Val Leu Thr Arg Ala Gly His Ala Asp Val Arg Ile Met 
     850                855                860
Phe Arg Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly 
 865                870                875                880
Phe His Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu 
                 885                890                895
Ser His Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu 
             900                905                910
Pro Thr Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Ser 
         915                920                925
Val Val Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu 
     930                935                940
Ala Pro Gln Ile Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe 
 945                950                955                960
Leu Asn Leu Ser Ser Ser Tyr Ser Met Ala Val Arg Ile Ala Ala Leu 
                 965                970                975
Gln Cys Met His Ala Leu Thr Arg Leu Pro Thr Ser Val Leu Leu Pro 
             980                985                990
Tyr Lys Ser Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys 
         995                1000                1005
Lys Arg Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe 
     1010                1015                1020
Leu Leu Gly Ser Pro Gly Ser 
 1025                1030



<210> 4336
<211> 2181
<212> DNA
<213> Homo sapiens
<308> AK025496
<400> 4336

aatggagct  tgaagacaa  gatcaaagg  ctctgaatg  cttcaagga  cagctgtgc  60
cactggtat  catggctct  acagacccc  gcacccagc  tcagcttgt  ggcatccgt  120
cactgacag  cttgggtgc  cagccagat  tcctatctt  tgaggactt  gagctggca  180
tgggtcacc  gtacagact  agcttcctg  aggaggatt  ccagagttg  agggtggca  240
cactggaag  atcaggaac  ctggctgct  tctaccctg  ggccttcag  agccacctc  300
tacccaagc  cgctgagga  ctgcgtgta  gggagtcaa  tttgactaa  ggagatgag  360
ccacccaat  ctcccggca  ctgtgctgt  tgcaagcct  gtcagctgt  tcaacacat  420
ccagcatcg  caaggagac  ctgcctctg  tgctgcagc  tctctggca  gtgaacaga  480
ggaatatgg  tgcacaatc  agtgacgtt  ttgctgtct  tcagagcct  agacagatg  540
cagaaaaat  tcagcagga  cctgagagt  gctggtatt  ccaccagac  gctatacct  600
gcctgcttg  cttggctgt  caggcctct  tgccagaga  ggagccctc  gttctgaga  660
aagtactat  ggaggatga  gtgttggct  ccatggtgt  tgtcattgg  actgctaca  720
cccacctga  ccctgagtt  gctgcccag  gtgtgacac  cattgtgcc  ctcttcttg  780
atggcaacg  gtcctttct  cctgaaaac  gcttcccga  cagattcca  ccattccag  840
atggctcct  agggcagag  cggctgatt  cactgctta  ggcctttgt  tgctccctg  900
ctcgaaatg  ggaaatccc  cagctgaac  aactcatgc  ggagctttt  gaactgagc  960
gctgccaca  ctgcccctt  tcttccacc  ctgctgcca  gtgctttgc  ggactcctc  1020
acaagcacc  tgcagggca  cagctggat  aattcctac  gctagctgt  gacaaagtg  1080
aggctggcc  gggctctgg  ccctgtcgt  gtcaggcct  cactcttct  ctctgggta  1140
taaaggccc  agtgctcag  taccatcct  tcagctcct  ccttacagc  cggctcatg  1200
gcctcctga  tgacccaga  ttaggtcca  cagcagctg  tggcttctc  ctgctcatg  1260
ctgactgca  tgatgtgct  actcgtgct  gccatgctg  agtgcggat  atgttccgc  1320
agcggttct  cacagataa  gtgcctgct  tggtccagg  cttccatgc  gctccccaa  1380
atgtgaagc  aaactactt  aagggtctt  ctcatgtac  taacaggct  cccaagcct  1440
tactcttgc  agagctgcc  acggccctg  cctgccctg  ctgtgtggt  cagctctcc  1500
ccctcagct  ccttcagcc  cttctactg  aagcacccc  agtcatgag  cttcacgtg  1560
acaccctcg  caccaagtt  ctgaacctc  gctctagcc  ttccatggc  gtccggatc  1620
ccgcactgc  gtgcatgca  gctctcact  gcctgccca  ccctgtgct  ctgccgtac  1680
aaccacagg  gattcgggc  ttagccaaa  ccctggatg  caagaagag  ctggtgcgc  1740
aggaagcag  gtcagccag  ggggagtgg  ttctgttgg  gagccctgg  agctgagcc  1800
tcagtcctg  cctagactg  tctgacaat  taacctggg  ttactaact  ttgagccat  1860
ttccccaaa  cagggaaac  actggtctc  gactgcctt  cccacagac  cagcacaaa  1920
gctaggcct  tgttgcatg  ctgtacaaa  aacataaga  tccatattt  tagtggatt  1980
gtaaaataa  tgtgtgtga  acacttgcg  ttgaagaaa  atctagggt  ctgggtctc  2040
tgcatttat  tgtcagaaa  ggggcgata  gctgctgag  ggtgagtgc  tatgagtgt  2100
gccctgagg  ccagggctg  cagatgttg  ctacctgct  aagaataaa  atttctttt  2160
gtaaaaaaa  aaaaaaaaa  a  2181



<210> 4337
<211> 293
<212> PRT
<213> Homo sapiens
<308> BC009396
<400> 4337

Met Arg Glu Leu Leu Glu Leu Ser Cys Cys His Ser Cys Pro Phe Ser 
  1               5                  10                  15
Ser Thr Ala Ala Ala Lys Cys Phe Ala Gly Leu Leu Asn Lys His Pro 
             20                  25                  30
Ala Gly Gln Gln Leu Asp Glu Phe Leu Gln Leu Ala Val Asp Lys Val 
         35                  40                  45
Glu Ala Gly Leu Gly Ser Gly Pro Cys Arg Ser Gln Ala Phe Thr Leu 
     50                  55                  60
Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro Leu Ser 
 65                  70                  75                  80
Ser Cys Leu Thr Ala Arg Leu Met Gly Leu Leu Ser Asp Pro Glu Leu 
                 85                  90                  95
Gly Pro Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp Cys Thr 
             100                105                110
Asp Val Leu Thr Arg Ala Gly His Ala Glu Val Arg Ile Met Phe Arg 
         115                120                125
Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly Phe His 
     130                135                140
Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu Ser His 
 145                150                155                160
Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu Pro Thr 
                 165                170                175
Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Cys Val Val 
             180                185                190
Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu Ala Pro 
         195                200                205
Gln Val Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe Leu Asn 
     210                215                220
Leu Ser Ser Ser Pro Ser Met Ala Val Arg Ile Ala Ala Leu Gln Cys 
 225                230                235                240
Met His Ala Leu Thr Arg Leu Pro Thr Pro Val Leu Leu Pro Tyr Lys 
                 245                250                255
Pro Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys Lys Arg 
             260                265                270
Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe Leu Leu 
         275                280                285
Gly Ser Pro Gly Ser 
     290



<210> 4338
<211> 595
<212> DNA
<213> Rattus norvegicus
<308> AA799566
<400> 4338

gcccattac  aaagtcttt  ttcgctggc  ggtgcattc  tgtaacaca  atccctagt  60
ctcaaggtc  cactcaact  gattggccc  tcagcagca  agccacgta  tgtcctgat  120
ggacacagg  gagcccaag  tcttttcct  aaatacaag  ctcagtctc  tcaacaatc  180
attagaaat  atggctctt  gaaaagagt  ttgcacagc  atgcaggag  ggcccagca  240
ttgtactgc  tccatgggc  ggcaggcca  tgggtggtc  tgccttgtg  gatggctca  300
tattagtac  tgcgggtta  attgtcagg  gggtttagg  gaggaccaa  ggctcagct  360
ccagggctc  ccagtagga  ccattctcc  cttgctgac  ctgcttcct  gcgcacaag  420
ctcttcttg  catccagag  cttggctaa  gctcggatc  cctgagatt  gaatggcag  480
aacacagaa  tggggtacc  agtgagagc  tgcatacac  gcagagcag  aatccggac  540
gccattgaa  gactggaac  gaaggtcag  agtttcgtg  caagttatc  catga  595



<210> 4339
<211> 1031
<212> PRT
<213> Rattus norvegicus
<308> AAK52670
<400> 4339

Met Ala Ala Ala Thr Gly Leu Glu Glu Ala Val Ala Pro Met Gly Ala 
  1               5                  10                  15
Leu Cys Gly Leu Val Gln Asp Phe Val Met Gly Gln Gln Glu Gly Pro 
             20                  25                  30
Ala Asp Gln Val Ala Ala Asp Val Lys Ser Gly Gly Tyr Thr Val Leu 
         35                  40                  45
Gln Val Val Glu Ala Leu Gly Ser Ser Leu Glu Asn Ala Glu Pro Arg 
     50                  55                  60
Thr Arg Ala Arg Gly Ala Gln Leu Leu Ser Gln Val Leu Leu Gln Cys 
 65                  70                  75                  80
His Ser Leu Leu Ser Glu Lys Glu Val Val His Leu Ile Leu Phe Tyr 
                 85                  90                  95
Glu Asn Arg Leu Lys Asp His His Leu Val Val Pro Ser Val Leu Gln 
             100                105                110
Gly Leu Arg Ala Leu Ser Met Ser Val Ala Leu Pro Pro Gly Leu Ala 
         115                120                125
Val Ser Val Leu Lys Ala Ile Phe Gln Glu Val His Val Gln Ser Leu 
     130                135                140
Leu Gln Val Asp Arg His Thr Val Phe Ser Ile Ile Thr Asn Phe Met 
 145                150                155                160
Arg Ser Arg Glu Glu Glu Leu Lys Gly Leu Gly Ala Asp Phe Thr Phe 
                 165                170                175
Gly Phe Ile Gln Val Met Asp Gly Glu Lys Asp Pro Arg Asn Leu Leu 
             180                185                190
Leu Ala Phe Arg Ile Val His Asp Leu Ile Ser Lys Asp Tyr Ser Leu 
         195                200                205
Gly Pro Phe Val Glu Glu Leu Phe Glu Val Thr Ser Cys Tyr Phe Pro 
     210                215                220
Ile Asp Phe Thr Pro Pro Pro Asn Asp Pro Tyr Gly Val Gln Arg Glu 
 225                230                235                240
Asp Leu Ile Leu Ser Leu Arg Ala Val Leu Ala Ser Thr Pro Arg Phe 
                 245                250                255
Ala Glu Phe Leu Leu Pro Leu Leu Ile Glu Lys Val Asp Ser Glu Ile 
             260                265                270
Leu Ser Ala Lys Leu Asp Ser Leu Gln Thr Leu Asn Ala Cys Cys Ala 
         275                280                285
Val Tyr Gly Gln Lys Glu Leu Lys Asp Phe Leu Pro Ser Leu Trp Ala 
     290                295                300
Ser Ile Arg Arg Glu Val Phe Gln Thr Ala Ser Glu Arg Val Glu Ala 
 305                310                315                320
Glu Gly Leu Ala Ala Leu His Ser Leu Thr Ala Cys Leu Ser Cys Ser 
                 325                330                335
Val Leu Arg Ala Asp Ala Glu Asp Leu Leu Gly Ser Phe Leu Ser Asn 
             340                345                350
Ile Leu Gln Asp Cys Arg His His Leu Cys Glu Pro Asp Met Lys Leu 
         355                360                365
Val Trp Pro Ser Ala Lys Leu Leu Gln Ala Ala Ala Gly Ala Ser Ala 
     370                375                380
Arg Ala Cys Glu His Leu Thr Ser Asn Val Leu Pro Leu Leu Leu Glu 
 385                390                395                400
Gln Phe His Lys His Ser Gln Ser Asn Gln Arg Arg Thr Ile Leu Glu 
                 405                410                415
Met Ile Leu Gly Phe Leu Lys Leu Gln Gln Lys Trp Ser Tyr Glu Asp 
             420                425                430
Arg Asp Glu Arg Pro Leu Ser Ser Phe Lys Asp Gln Leu Cys Ser Leu 
         435                440                445
Val Phe Met Ala Leu Thr Asp Pro Ser Thr Gln Leu Gln Leu Val Gly 
     450                455                460
Ile Arg Thr Leu Thr Val Leu Gly Ala Gln Pro Gly Leu Leu Ser Ala 
 465                470                475                480
Glu Asp Leu Glu Leu Ala Val Gly His Leu Tyr Arg Leu Thr Phe Leu 
                 485                490                495
Glu Glu Asp Ser Gln Ser Cys Arg Val Ala Ala Leu Glu Ala Ser Gly 
             500                505                510
Thr Leu Ala Thr Leu Tyr Pro Gly Ala Phe Ser Arg His Leu Leu Pro 
         515                520                525
Lys Leu Ala Glu Glu Leu His Lys Gly Glu Ser Asp Val Ala Arg Ala 
     530                535                540
Asp Gly Pro Thr Lys Cys Ser Arg His Phe Arg Cys Leu Gln Ala Leu 
 545                550                555                560
Ser Ala Val Ser Thr His Pro Ser Ile Val Lys Glu Thr Leu Pro Leu 
                 565                570                575
Leu Leu Gln His Leu Cys Gln Ala Asn Lys Gly Asn Met Val Thr Glu 
             580                585                590
Ser Ser Glu Val Val Ala Val Cys Gln Ser Leu Gln Gln Val Ala Glu 
         595                600                605
Lys Cys Gln Gln Asp Pro Glu Ser Tyr Trp Tyr Phe His Lys Thr Ala 
     610                615                620
Val Pro Cys Leu Phe Ala Leu Ala Val Gln Ala Ser Met Pro Glu Lys 
 625                630                635                640
Glu Ser Ser Val Leu Arg Lys Val Leu Leu Glu Asp Glu Val Leu Ala 
                 645                650                655
Ala Leu Ala Ser Val Ile Gly Thr Ala Thr Thr His Leu Ser Pro Glu 
             660                665                670
Leu Ala Ala Gln Ser Val Thr Cys Val Val Pro Leu Phe Leu Asp Gly 
         675                680                685
Asn Thr Ser Phe Leu Pro Glu Asn Ser Phe Pro Asp Gln Phe Gln Pro 
     690                695                700
Phe Gln Asp Gly Ser Ser Gly Gln Arg Arg Leu Val Ala Leu Leu Thr 
 705                710                715                720
Ala Phe Val Cys Ser Leu Pro Arg Asn Val Glu Ile Pro Gln Leu Asn 
                 725                730                735
Arg Leu Met Arg Glu Leu Leu Lys Gln Ser Cys Gly His Ser Cys Pro 
             740                745                750
Phe Ser Ser Thr Ala Ala Thr Lys Cys Phe Ala Gly Leu Leu Asn Lys 
         755                760                765
Gln Pro Pro Gly Gln Gln Leu Glu Glu Phe Leu Gln Leu Ala Val Gly 
     770                775                780
Thr Val Glu Ala Gly Leu Ala Ser Glu Ser Ser Arg Asp Gln Ala Phe 
 785                790                795                800
Thr Leu Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro 
                 805                810                815
Leu Ser Ala Cys Leu Thr Thr Arg Leu Met Gly Leu Leu Ser Asp Pro 
             820                825                830
Glu Leu Gly Cys Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp 
         835                840                845
Cys Thr Asp Val Leu Thr Arg Ala Gly His Ala Asp Val Arg Ile Met 
     850                855                860
Phe Arg Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly 
 865                870                875                880
Phe His Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu 
                 885                890                895
Ser His Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu 
             900                905                910
Pro Thr Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Ser 
         915                920                925
Val Val Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu 
     930                935                940
Ala Pro Gln Ile Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe 
 945                950                955                960
Leu Asn Leu Ser Ser Ser Tyr Ser Met Ala Val Arg Ile Ala Ala Leu 
                 965                970                975
Gln Cys Met His Ala Leu Thr Arg Leu Pro Thr Ser Val Leu Leu Pro 
             980                985                990
Tyr Lys Ser Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys 
         995                1000                1005
Lys Arg Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe 
     1010                1015                1020
Leu Leu Gly Ser Pro Gly Ser 
 1025                1030



<210> 4340
<211> 2181
<212> DNA
<213> Homo sapiens
<308> AK025496
<400> 4340

aatggagct  tgaagacaa  gatcaaagg  ctctgaatg  cttcaagga  cagctgtgc  60
cactggtat  catggctct  acagacccc  gcacccagc  tcagcttgt  ggcatccgt  120
cactgacag  cttgggtgc  cagccagat  tcctatctt  tgaggactt  gagctggca  180
tgggtcacc  gtacagact  agcttcctg  aggaggatt  ccagagttg  agggtggca  240
cactggaag  atcaggaac  ctggctgct  tctaccctg  ggccttcag  agccacctc  300
tacccaagc  cgctgagga  ctgcgtgta  gggagtcaa  tttgactaa  ggagatgag  360
ccacccaat  ctcccggca  ctgtgctgt  tgcaagcct  gtcagctgt  tcaacacat  420
ccagcatcg  caaggagac  ctgcctctg  tgctgcagc  tctctggca  gtgaacaga  480
ggaatatgg  tgcacaatc  agtgacgtt  ttgctgtct  tcagagcct  agacagatg  540
cagaaaaat  tcagcagga  cctgagagt  gctggtatt  ccaccagac  gctatacct  600
gcctgcttg  cttggctgt  caggcctct  tgccagaga  ggagccctc  gttctgaga  660
aagtactat  ggaggatga  gtgttggct  ccatggtgt  tgtcattgg  actgctaca  720
cccacctga  ccctgagtt  gctgcccag  gtgtgacac  cattgtgcc  ctcttcttg  780
atggcaacg  gtcctttct  cctgaaaac  gcttcccga  cagattcca  ccattccag  840
atggctcct  agggcagag  cggctgatt  cactgctta  ggcctttgt  tgctccctg  900
ctcgaaatg  ggaaatccc  cagctgaac  aactcatgc  ggagctttt  gaactgagc  960
gctgccaca  ctgcccctt  tcttccacc  ctgctgcca  gtgctttgc  ggactcctc  1020
acaagcacc  tgcagggca  cagctggat  aattcctac  gctagctgt  gacaaagtg  1080
aggctggcc  gggctctgg  ccctgtcgt  gtcaggcct  cactcttct  ctctgggta  1140
taaaggccc  agtgctcag  taccatcct  tcagctcct  ccttacagc  cggctcatg  1200
gcctcctga  tgacccaga  ttaggtcca  cagcagctg  tggcttctc  ctgctcatg  1260
ctgactgca  tgatgtgct  actcgtgct  gccatgctg  agtgcggat  atgttccgc  1320
agcggttct  cacagataa  gtgcctgct  tggtccagg  cttccatgc  gctccccaa  1380
atgtgaagc  aaactactt  aagggtctt  ctcatgtac  taacaggct  cccaagcct  1440
tactcttgc  agagctgcc  acggccctg  cctgccctg  ctgtgtggt  cagctctcc  1500
ccctcagct  ccttcagcc  cttctactg  aagcacccc  agtcatgag  cttcacgtg  1560
acaccctcg  caccaagtt  ctgaacctc  gctctagcc  ttccatggc  gtccggatc  1620
ccgcactgc  gtgcatgca  gctctcact  gcctgccca  ccctgtgct  ctgccgtac  1680
aaccacagg  gattcgggc  ttagccaaa  ccctggatg  caagaagag  ctggtgcgc  1740
aggaagcag  gtcagccag  ggggagtgg  ttctgttgg  gagccctgg  agctgagcc  1800
tcagtcctg  cctagactg  tctgacaat  taacctggg  ttactaact  ttgagccat  1860
ttccccaaa  cagggaaac  actggtctc  gactgcctt  cccacagac  cagcacaaa  1920
gctaggcct  tgttgcatg  ctgtacaaa  aacataaga  tccatattt  tagtggatt  1980
gtaaaataa  tgtgtgtga  acacttgcg  ttgaagaaa  atctagggt  ctgggtctc  2040
tgcatttat  tgtcagaaa  ggggcgata  gctgctgag  ggtgagtgc  tatgagtgt  2100
gccctgagg  ccagggctg  cagatgttg  ctacctgct  aagaataaa  atttctttt  2160
gtaaaaaaa  aaaaaaaaa  a  2181



<210> 4341
<211> 293
<212> PRT
<213> Homo sapiens
<308> BC009396
<400> 4341

Met Arg Glu Leu Leu Glu Leu Ser Cys Cys His Ser Cys Pro Phe Ser 
  1               5                  10                  15
Ser Thr Ala Ala Ala Lys Cys Phe Ala Gly Leu Leu Asn Lys His Pro 
             20                  25                  30
Ala Gly Gln Gln Leu Asp Glu Phe Leu Gln Leu Ala Val Asp Lys Val 
         35                  40                  45
Glu Ala Gly Leu Gly Ser Gly Pro Cys Arg Ser Gln Ala Phe Thr Leu 
     50                  55                  60
Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro Leu Ser 
 65                  70                  75                  80
Ser Cys Leu Thr Ala Arg Leu Met Gly Leu Leu Ser Asp Pro Glu Leu 
                 85                  90                  95
Gly Pro Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp Cys Thr 
             100                105                110
Asp Val Leu Thr Arg Ala Gly His Ala Glu Val Arg Ile Met Phe Arg 
         115                120                125
Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly Phe His 
     130                135                140
Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu Ser His 
 145                150                155                160
Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu Pro Thr 
                 165                170                175
Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Cys Val Val 
             180                185                190
Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu Ala Pro 
         195                200                205
Gln Val Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe Leu Asn 
     210                215                220
Leu Ser Ser Ser Pro Ser Met Ala Val Arg Ile Ala Ala Leu Gln Cys 
 225                230                235                240
Met His Ala Leu Thr Arg Leu Pro Thr Pro Val Leu Leu Pro Tyr Lys 
                 245                250                255
Pro Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys Lys Arg 
             260                265                270
Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe Leu Leu 
         275                280                285
Gly Ser Pro Gly Ser 
     290



<210> 4342
<211> 595
<212> DNA
<213> Rattus norvegicus
<308> AA799566
<400> 4342

gcccattac  aaagtcttt  ttcgctggc  ggtgcattc  tgtaacaca  atccctagt  60
ctcaaggtc  cactcaact  gattggccc  tcagcagca  agccacgta  tgtcctgat  120
ggacacagg  gagcccaag  tcttttcct  aaatacaag  ctcagtctc  tcaacaatc  180
attagaaat  atggctctt  gaaaagagt  ttgcacagc  atgcaggag  ggcccagca  240
ttgtactgc  tccatgggc  ggcaggcca  tgggtggtc  tgccttgtg  gatggctca  300
tattagtac  tgcgggtta  attgtcagg  gggtttagg  gaggaccaa  ggctcagct  360
ccagggctc  ccagtagga  ccattctcc  cttgctgac  ctgcttcct  gcgcacaag  420
ctcttcttg  catccagag  cttggctaa  gctcggatc  cctgagatt  gaatggcag  480
aacacagaa  tggggtacc  agtgagagc  tgcatacac  gcagagcag  aatccggac  540
gccattgaa  gactggaac  gaaggtcag  agtttcgtg  caagttatc  catga  595



<210> 4343
<211> 1031
<212> PRT
<213> Rattus norvegicus
<308> AAK52670
<400> 4343

Met Ala Ala Ala Thr Gly Leu Glu Glu Ala Val Ala Pro Met Gly Ala 
  1               5                  10                  15
Leu Cys Gly Leu Val Gln Asp Phe Val Met Gly Gln Gln Glu Gly Pro 
             20                  25                  30
Ala Asp Gln Val Ala Ala Asp Val Lys Ser Gly Gly Tyr Thr Val Leu 
         35                  40                  45
Gln Val Val Glu Ala Leu Gly Ser Ser Leu Glu Asn Ala Glu Pro Arg 
     50                  55                  60
Thr Arg Ala Arg Gly Ala Gln Leu Leu Ser Gln Val Leu Leu Gln Cys 
 65                  70                  75                  80
His Ser Leu Leu Ser Glu Lys Glu Val Val His Leu Ile Leu Phe Tyr 
                 85                  90                  95
Glu Asn Arg Leu Lys Asp His His Leu Val Val Pro Ser Val Leu Gln 
             100                105                110
Gly Leu Arg Ala Leu Ser Met Ser Val Ala Leu Pro Pro Gly Leu Ala 
         115                120                125
Val Ser Val Leu Lys Ala Ile Phe Gln Glu Val His Val Gln Ser Leu 
     130                135                140
Leu Gln Val Asp Arg His Thr Val Phe Ser Ile Ile Thr Asn Phe Met 
 145                150                155                160
Arg Ser Arg Glu Glu Glu Leu Lys Gly Leu Gly Ala Asp Phe Thr Phe 
                 165                170                175
Gly Phe Ile Gln Val Met Asp Gly Glu Lys Asp Pro Arg Asn Leu Leu 
             180                185                190
Leu Ala Phe Arg Ile Val His Asp Leu Ile Ser Lys Asp Tyr Ser Leu 
         195                200                205
Gly Pro Phe Val Glu Glu Leu Phe Glu Val Thr Ser Cys Tyr Phe Pro 
     210                215                220
Ile Asp Phe Thr Pro Pro Pro Asn Asp Pro Tyr Gly Val Gln Arg Glu 
 225                230                235                240
Asp Leu Ile Leu Ser Leu Arg Ala Val Leu Ala Ser Thr Pro Arg Phe 
                 245                250                255
Ala Glu Phe Leu Leu Pro Leu Leu Ile Glu Lys Val Asp Ser Glu Ile 
             260                265                270
Leu Ser Ala Lys Leu Asp Ser Leu Gln Thr Leu Asn Ala Cys Cys Ala 
         275                280                285
Val Tyr Gly Gln Lys Glu Leu Lys Asp Phe Leu Pro Ser Leu Trp Ala 
     290                295                300
Ser Ile Arg Arg Glu Val Phe Gln Thr Ala Ser Glu Arg Val Glu Ala 
 305                310                315                320
Glu Gly Leu Ala Ala Leu His Ser Leu Thr Ala Cys Leu Ser Cys Ser 
                 325                330                335
Val Leu Arg Ala Asp Ala Glu Asp Leu Leu Gly Ser Phe Leu Ser Asn 
             340                345                350
Ile Leu Gln Asp Cys Arg His His Leu Cys Glu Pro Asp Met Lys Leu 
         355                360                365
Val Trp Pro Ser Ala Lys Leu Leu Gln Ala Ala Ala Gly Ala Ser Ala 
     370                375                380
Arg Ala Cys Glu His Leu Thr Ser Asn Val Leu Pro Leu Leu Leu Glu 
 385                390                395                400
Gln Phe His Lys His Ser Gln Ser Asn Gln Arg Arg Thr Ile Leu Glu 
                 405                410                415
Met Ile Leu Gly Phe Leu Lys Leu Gln Gln Lys Trp Ser Tyr Glu Asp 
             420                425                430
Arg Asp Glu Arg Pro Leu Ser Ser Phe Lys Asp Gln Leu Cys Ser Leu 
         435                440                445
Val Phe Met Ala Leu Thr Asp Pro Ser Thr Gln Leu Gln Leu Val Gly 
     450                455                460
Ile Arg Thr Leu Thr Val Leu Gly Ala Gln Pro Gly Leu Leu Ser Ala 
 465                470                475                480
Glu Asp Leu Glu Leu Ala Val Gly His Leu Tyr Arg Leu Thr Phe Leu 
                 485                490                495
Glu Glu Asp Ser Gln Ser Cys Arg Val Ala Ala Leu Glu Ala Ser Gly 
             500                505                510
Thr Leu Ala Thr Leu Tyr Pro Gly Ala Phe Ser Arg His Leu Leu Pro 
         515                520                525
Lys Leu Ala Glu Glu Leu His Lys Gly Glu Ser Asp Val Ala Arg Ala 
     530                535                540
Asp Gly Pro Thr Lys Cys Ser Arg His Phe Arg Cys Leu Gln Ala Leu 
 545                550                555                560
Ser Ala Val Ser Thr His Pro Ser Ile Val Lys Glu Thr Leu Pro Leu 
                 565                570                575
Leu Leu Gln His Leu Cys Gln Ala Asn Lys Gly Asn Met Val Thr Glu 
             580                585                590
Ser Ser Glu Val Val Ala Val Cys Gln Ser Leu Gln Gln Val Ala Glu 
         595                600                605
Lys Cys Gln Gln Asp Pro Glu Ser Tyr Trp Tyr Phe His Lys Thr Ala 
     610                615                620
Val Pro Cys Leu Phe Ala Leu Ala Val Gln Ala Ser Met Pro Glu Lys 
 625                630                635                640
Glu Ser Ser Val Leu Arg Lys Val Leu Leu Glu Asp Glu Val Leu Ala 
                 645                650                655
Ala Leu Ala Ser Val Ile Gly Thr Ala Thr Thr His Leu Ser Pro Glu 
             660                665                670
Leu Ala Ala Gln Ser Val Thr Cys Val Val Pro Leu Phe Leu Asp Gly 
         675                680                685
Asn Thr Ser Phe Leu Pro Glu Asn Ser Phe Pro Asp Gln Phe Gln Pro 
     690                695                700
Phe Gln Asp Gly Ser Ser Gly Gln Arg Arg Leu Val Ala Leu Leu Thr 
 705                710                715                720
Ala Phe Val Cys Ser Leu Pro Arg Asn Val Glu Ile Pro Gln Leu Asn 
                 725                730                735
Arg Leu Met Arg Glu Leu Leu Lys Gln Ser Cys Gly His Ser Cys Pro 
             740                745                750
Phe Ser Ser Thr Ala Ala Thr Lys Cys Phe Ala Gly Leu Leu Asn Lys 
         755                760                765
Gln Pro Pro Gly Gln Gln Leu Glu Glu Phe Leu Gln Leu Ala Val Gly 
     770                775                780
Thr Val Glu Ala Gly Leu Ala Ser Glu Ser Ser Arg Asp Gln Ala Phe 
 785                790                795                800
Thr Leu Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro 
                 805                810                815
Leu Ser Ala Cys Leu Thr Thr Arg Leu Met Gly Leu Leu Ser Asp Pro 
             820                825                830
Glu Leu Gly Cys Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp 
         835                840                845
Cys Thr Asp Val Leu Thr Arg Ala Gly His Ala Asp Val Arg Ile Met 
     850                855                860
Phe Arg Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly 
 865                870                875                880
Phe His Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu 
                 885                890                895
Ser His Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu 
             900                905                910
Pro Thr Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Ser 
         915                920                925
Val Val Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu 
     930                935                940
Ala Pro Gln Ile Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe 
 945                950                955                960
Leu Asn Leu Ser Ser Ser Tyr Ser Met Ala Val Arg Ile Ala Ala Leu 
                 965                970                975
Gln Cys Met His Ala Leu Thr Arg Leu Pro Thr Ser Val Leu Leu Pro 
             980                985                990
Tyr Lys Ser Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys 
         995                1000                1005
Lys Arg Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe 
     1010                1015                1020
Leu Leu Gly Ser Pro Gly Ser 
 1025                1030



<210> 4344
<211> 2181
<212> DNA
<213> Homo sapiens
<308> AK025496
<400> 4344

aatggagct  tgaagacaa  gatcaaagg  ctctgaatg  cttcaagga  cagctgtgc  60
cactggtat  catggctct  acagacccc  gcacccagc  tcagcttgt  ggcatccgt  120
cactgacag  cttgggtgc  cagccagat  tcctatctt  tgaggactt  gagctggca  180
tgggtcacc  gtacagact  agcttcctg  aggaggatt  ccagagttg  agggtggca  240
cactggaag  atcaggaac  ctggctgct  tctaccctg  ggccttcag  agccacctc  300
tacccaagc  cgctgagga  ctgcgtgta  gggagtcaa  tttgactaa  ggagatgag  360
ccacccaat  ctcccggca  ctgtgctgt  tgcaagcct  gtcagctgt  tcaacacat  420
ccagcatcg  caaggagac  ctgcctctg  tgctgcagc  tctctggca  gtgaacaga  480
ggaatatgg  tgcacaatc  agtgacgtt  ttgctgtct  tcagagcct  agacagatg  540
cagaaaaat  tcagcagga  cctgagagt  gctggtatt  ccaccagac  gctatacct  600
gcctgcttg  cttggctgt  caggcctct  tgccagaga  ggagccctc  gttctgaga  660
aagtactat  ggaggatga  gtgttggct  ccatggtgt  tgtcattgg  actgctaca  720
cccacctga  ccctgagtt  gctgcccag  gtgtgacac  cattgtgcc  ctcttcttg  780
atggcaacg  gtcctttct  cctgaaaac  gcttcccga  cagattcca  ccattccag  840
atggctcct  agggcagag  cggctgatt  cactgctta  ggcctttgt  tgctccctg  900
ctcgaaatg  ggaaatccc  cagctgaac  aactcatgc  ggagctttt  gaactgagc  960
gctgccaca  ctgcccctt  tcttccacc  ctgctgcca  gtgctttgc  ggactcctc  1020
acaagcacc  tgcagggca  cagctggat  aattcctac  gctagctgt  gacaaagtg  1080
aggctggcc  gggctctgg  ccctgtcgt  gtcaggcct  cactcttct  ctctgggta  1140
taaaggccc  agtgctcag  taccatcct  tcagctcct  ccttacagc  cggctcatg  1200
gcctcctga  tgacccaga  ttaggtcca  cagcagctg  tggcttctc  ctgctcatg  1260
ctgactgca  tgatgtgct  actcgtgct  gccatgctg  agtgcggat  atgttccgc  1320
agcggttct  cacagataa  gtgcctgct  tggtccagg  cttccatgc  gctccccaa  1380
atgtgaagc  aaactactt  aagggtctt  ctcatgtac  taacaggct  cccaagcct  1440
tactcttgc  agagctgcc  acggccctg  cctgccctg  ctgtgtggt  cagctctcc  1500
ccctcagct  ccttcagcc  cttctactg  aagcacccc  agtcatgag  cttcacgtg  1560
acaccctcg  caccaagtt  ctgaacctc  gctctagcc  ttccatggc  gtccggatc  1620
ccgcactgc  gtgcatgca  gctctcact  gcctgccca  ccctgtgct  ctgccgtac  1680
aaccacagg  gattcgggc  ttagccaaa  ccctggatg  caagaagag  ctggtgcgc  1740
aggaagcag  gtcagccag  ggggagtgg  ttctgttgg  gagccctgg  agctgagcc  1800
tcagtcctg  cctagactg  tctgacaat  taacctggg  ttactaact  ttgagccat  1860
ttccccaaa  cagggaaac  actggtctc  gactgcctt  cccacagac  cagcacaaa  1920
gctaggcct  tgttgcatg  ctgtacaaa  aacataaga  tccatattt  tagtggatt  1980
gtaaaataa  tgtgtgtga  acacttgcg  ttgaagaaa  atctagggt  ctgggtctc  2040
tgcatttat  tgtcagaaa  ggggcgata  gctgctgag  ggtgagtgc  tatgagtgt  2100
gccctgagg  ccagggctg  cagatgttg  ctacctgct  aagaataaa  atttctttt  2160
gtaaaaaaa  aaaaaaaaa  a  2181



<210> 4345
<211> 293
<212> PRT
<213> Homo sapiens
<308> BC009396
<400> 4345

Met Arg Glu Leu Leu Glu Leu Ser Cys Cys His Ser Cys Pro Phe Ser 
  1               5                  10                  15
Ser Thr Ala Ala Ala Lys Cys Phe Ala Gly Leu Leu Asn Lys His Pro 
             20                  25                  30
Ala Gly Gln Gln Leu Asp Glu Phe Leu Gln Leu Ala Val Asp Lys Val 
         35                  40                  45
Glu Ala Gly Leu Gly Ser Gly Pro Cys Arg Ser Gln Ala Phe Thr Leu 
     50                  55                  60
Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro Leu Ser 
 65                  70                  75                  80
Ser Cys Leu Thr Ala Arg Leu Met Gly Leu Leu Ser Asp Pro Glu Leu 
                 85                  90                  95
Gly Pro Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp Cys Thr 
             100                105                110
Asp Val Leu Thr Arg Ala Gly His Ala Glu Val Arg Ile Met Phe Arg 
         115                120                125
Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly Phe His 
     130                135                140
Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu Ser His 
 145                150                155                160
Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu Pro Thr 
                 165                170                175
Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Cys Val Val 
             180                185                190
Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu Ala Pro 
         195                200                205
Gln Val Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe Leu Asn 
     210                215                220
Leu Ser Ser Ser Pro Ser Met Ala Val Arg Ile Ala Ala Leu Gln Cys 
 225                230                235                240
Met His Ala Leu Thr Arg Leu Pro Thr Pro Val Leu Leu Pro Tyr Lys 
                 245                250                255
Pro Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys Lys Arg 
             260                265                270
Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe Leu Leu 
         275                280                285
Gly Ser Pro Gly Ser 
     290



<210> 4346
<211> 595
<212> DNA
<213> Rattus norvegicus
<308> AA799566
<400> 4346

gcccattac  aaagtcttt  ttcgctggc  ggtgcattc  tgtaacaca  atccctagt  60
ctcaaggtc  cactcaact  gattggccc  tcagcagca  agccacgta  tgtcctgat  120
ggacacagg  gagcccaag  tcttttcct  aaatacaag  ctcagtctc  tcaacaatc  180
attagaaat  atggctctt  gaaaagagt  ttgcacagc  atgcaggag  ggcccagca  240
ttgtactgc  tccatgggc  ggcaggcca  tgggtggtc  tgccttgtg  gatggctca  300
tattagtac  tgcgggtta  attgtcagg  gggtttagg  gaggaccaa  ggctcagct  360
ccagggctc  ccagtagga  ccattctcc  cttgctgac  ctgcttcct  gcgcacaag  420
ctcttcttg  catccagag  cttggctaa  gctcggatc  cctgagatt  gaatggcag  480
aacacagaa  tggggtacc  agtgagagc  tgcatacac  gcagagcag  aatccggac  540
gccattgaa  gactggaac  gaaggtcag  agtttcgtg  caagttatc  catga  595



<210> 4347
<211> 1031
<212> PRT
<213> Rattus norvegicus
<308> AAK52670
<400> 4347

Met Ala Ala Ala Thr Gly Leu Glu Glu Ala Val Ala Pro Met Gly Ala 
  1               5                  10                  15
Leu Cys Gly Leu Val Gln Asp Phe Val Met Gly Gln Gln Glu Gly Pro 
             20                  25                  30
Ala Asp Gln Val Ala Ala Asp Val Lys Ser Gly Gly Tyr Thr Val Leu 
         35                  40                  45
Gln Val Val Glu Ala Leu Gly Ser Ser Leu Glu Asn Ala Glu Pro Arg 
     50                  55                  60
Thr Arg Ala Arg Gly Ala Gln Leu Leu Ser Gln Val Leu Leu Gln Cys 
 65                  70                  75                  80
His Ser Leu Leu Ser Glu Lys Glu Val Val His Leu Ile Leu Phe Tyr 
                 85                  90                  95
Glu Asn Arg Leu Lys Asp His His Leu Val Val Pro Ser Val Leu Gln 
             100                105                110
Gly Leu Arg Ala Leu Ser Met Ser Val Ala Leu Pro Pro Gly Leu Ala 
         115                120                125
Val Ser Val Leu Lys Ala Ile Phe Gln Glu Val His Val Gln Ser Leu 
     130                135                140
Leu Gln Val Asp Arg His Thr Val Phe Ser Ile Ile Thr Asn Phe Met 
 145                150                155                160
Arg Ser Arg Glu Glu Glu Leu Lys Gly Leu Gly Ala Asp Phe Thr Phe 
                 165                170                175
Gly Phe Ile Gln Val Met Asp Gly Glu Lys Asp Pro Arg Asn Leu Leu 
             180                185                190
Leu Ala Phe Arg Ile Val His Asp Leu Ile Ser Lys Asp Tyr Ser Leu 
         195                200                205
Gly Pro Phe Val Glu Glu Leu Phe Glu Val Thr Ser Cys Tyr Phe Pro 
     210                215                220
Ile Asp Phe Thr Pro Pro Pro Asn Asp Pro Tyr Gly Val Gln Arg Glu 
 225                230                235                240
Asp Leu Ile Leu Ser Leu Arg Ala Val Leu Ala Ser Thr Pro Arg Phe 
                 245                250                255
Ala Glu Phe Leu Leu Pro Leu Leu Ile Glu Lys Val Asp Ser Glu Ile 
             260                265                270
Leu Ser Ala Lys Leu Asp Ser Leu Gln Thr Leu Asn Ala Cys Cys Ala 
         275                280                285
Val Tyr Gly Gln Lys Glu Leu Lys Asp Phe Leu Pro Ser Leu Trp Ala 
     290                295                300
Ser Ile Arg Arg Glu Val Phe Gln Thr Ala Ser Glu Arg Val Glu Ala 
 305                310                315                320
Glu Gly Leu Ala Ala Leu His Ser Leu Thr Ala Cys Leu Ser Cys Ser 
                 325                330                335
Val Leu Arg Ala Asp Ala Glu Asp Leu Leu Gly Ser Phe Leu Ser Asn 
             340                345                350
Ile Leu Gln Asp Cys Arg His His Leu Cys Glu Pro Asp Met Lys Leu 
         355                360                365
Val Trp Pro Ser Ala Lys Leu Leu Gln Ala Ala Ala Gly Ala Ser Ala 
     370                375                380
Arg Ala Cys Glu His Leu Thr Ser Asn Val Leu Pro Leu Leu Leu Glu 
 385                390                395                400
Gln Phe His Lys His Ser Gln Ser Asn Gln Arg Arg Thr Ile Leu Glu 
                 405                410                415
Met Ile Leu Gly Phe Leu Lys Leu Gln Gln Lys Trp Ser Tyr Glu Asp 
             420                425                430
Arg Asp Glu Arg Pro Leu Ser Ser Phe Lys Asp Gln Leu Cys Ser Leu 
         435                440                445
Val Phe Met Ala Leu Thr Asp Pro Ser Thr Gln Leu Gln Leu Val Gly 
     450                455                460
Ile Arg Thr Leu Thr Val Leu Gly Ala Gln Pro Gly Leu Leu Ser Ala 
 465                470                475                480
Glu Asp Leu Glu Leu Ala Val Gly His Leu Tyr Arg Leu Thr Phe Leu 
                 485                490                495
Glu Glu Asp Ser Gln Ser Cys Arg Val Ala Ala Leu Glu Ala Ser Gly 
             500                505                510
Thr Leu Ala Thr Leu Tyr Pro Gly Ala Phe Ser Arg His Leu Leu Pro 
         515                520                525
Lys Leu Ala Glu Glu Leu His Lys Gly Glu Ser Asp Val Ala Arg Ala 
     530                535                540
Asp Gly Pro Thr Lys Cys Ser Arg His Phe Arg Cys Leu Gln Ala Leu 
 545                550                555                560
Ser Ala Val Ser Thr His Pro Ser Ile Val Lys Glu Thr Leu Pro Leu 
                 565                570                575
Leu Leu Gln His Leu Cys Gln Ala Asn Lys Gly Asn Met Val Thr Glu 
             580                585                590
Ser Ser Glu Val Val Ala Val Cys Gln Ser Leu Gln Gln Val Ala Glu 
         595                600                605
Lys Cys Gln Gln Asp Pro Glu Ser Tyr Trp Tyr Phe His Lys Thr Ala 
     610                615                620
Val Pro Cys Leu Phe Ala Leu Ala Val Gln Ala Ser Met Pro Glu Lys 
 625                630                635                640
Glu Ser Ser Val Leu Arg Lys Val Leu Leu Glu Asp Glu Val Leu Ala 
                 645                650                655
Ala Leu Ala Ser Val Ile Gly Thr Ala Thr Thr His Leu Ser Pro Glu 
             660                665                670
Leu Ala Ala Gln Ser Val Thr Cys Val Val Pro Leu Phe Leu Asp Gly 
         675                680                685
Asn Thr Ser Phe Leu Pro Glu Asn Ser Phe Pro Asp Gln Phe Gln Pro 
     690                695                700
Phe Gln Asp Gly Ser Ser Gly Gln Arg Arg Leu Val Ala Leu Leu Thr 
 705                710                715                720
Ala Phe Val Cys Ser Leu Pro Arg Asn Val Glu Ile Pro Gln Leu Asn 
                 725                730                735
Arg Leu Met Arg Glu Leu Leu Lys Gln Ser Cys Gly His Ser Cys Pro 
             740                745                750
Phe Ser Ser Thr Ala Ala Thr Lys Cys Phe Ala Gly Leu Leu Asn Lys 
         755                760                765
Gln Pro Pro Gly Gln Gln Leu Glu Glu Phe Leu Gln Leu Ala Val Gly 
     770                775                780
Thr Val Glu Ala Gly Leu Ala Ser Glu Ser Ser Arg Asp Gln Ala Phe 
 785                790                795                800
Thr Leu Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro 
                 805                810                815
Leu Ser Ala Cys Leu Thr Thr Arg Leu Met Gly Leu Leu Ser Asp Pro 
             820                825                830
Glu Leu Gly Cys Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp 
         835                840                845
Cys Thr Asp Val Leu Thr Arg Ala Gly His Ala Asp Val Arg Ile Met 
     850                855                860
Phe Arg Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly 
 865                870                875                880
Phe His Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu 
                 885                890                895
Ser His Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu 
             900                905                910
Pro Thr Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Ser 
         915                920                925
Val Val Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu 
     930                935                940
Ala Pro Gln Ile Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe 
 945                950                955                960
Leu Asn Leu Ser Ser Ser Tyr Ser Met Ala Val Arg Ile Ala Ala Leu 
                 965                970                975
Gln Cys Met His Ala Leu Thr Arg Leu Pro Thr Ser Val Leu Leu Pro 
             980                985                990
Tyr Lys Ser Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys 
         995                1000                1005
Lys Arg Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe 
     1010                1015                1020
Leu Leu Gly Ser Pro Gly Ser 
 1025                1030



<210> 4348
<211> 2181
<212> DNA
<213> Homo sapiens
<308> AK025496
<400> 4348

aatggagct  tgaagacaa  gatcaaagg  ctctgaatg  cttcaagga  cagctgtgc  60
cactggtat  catggctct  acagacccc  gcacccagc  tcagcttgt  ggcatccgt  120
cactgacag  cttgggtgc  cagccagat  tcctatctt  tgaggactt  gagctggca  180
tgggtcacc  gtacagact  agcttcctg  aggaggatt  ccagagttg  agggtggca  240
cactggaag  atcaggaac  ctggctgct  tctaccctg  ggccttcag  agccacctc  300
tacccaagc  cgctgagga  ctgcgtgta  gggagtcaa  tttgactaa  ggagatgag  360
ccacccaat  ctcccggca  ctgtgctgt  tgcaagcct  gtcagctgt  tcaacacat  420
ccagcatcg  caaggagac  ctgcctctg  tgctgcagc  tctctggca  gtgaacaga  480
ggaatatgg  tgcacaatc  agtgacgtt  ttgctgtct  tcagagcct  agacagatg  540
cagaaaaat  tcagcagga  cctgagagt  gctggtatt  ccaccagac  gctatacct  600
gcctgcttg  cttggctgt  caggcctct  tgccagaga  ggagccctc  gttctgaga  660
aagtactat  ggaggatga  gtgttggct  ccatggtgt  tgtcattgg  actgctaca  720
cccacctga  ccctgagtt  gctgcccag  gtgtgacac  cattgtgcc  ctcttcttg  780
atggcaacg  gtcctttct  cctgaaaac  gcttcccga  cagattcca  ccattccag  840
atggctcct  agggcagag  cggctgatt  cactgctta  ggcctttgt  tgctccctg  900
ctcgaaatg  ggaaatccc  cagctgaac  aactcatgc  ggagctttt  gaactgagc  960
gctgccaca  ctgcccctt  tcttccacc  ctgctgcca  gtgctttgc  ggactcctc  1020
acaagcacc  tgcagggca  cagctggat  aattcctac  gctagctgt  gacaaagtg  1080
aggctggcc  gggctctgg  ccctgtcgt  gtcaggcct  cactcttct  ctctgggta  1140
taaaggccc  agtgctcag  taccatcct  tcagctcct  ccttacagc  cggctcatg  1200
gcctcctga  tgacccaga  ttaggtcca  cagcagctg  tggcttctc  ctgctcatg  1260
ctgactgca  tgatgtgct  actcgtgct  gccatgctg  agtgcggat  atgttccgc  1320
agcggttct  cacagataa  gtgcctgct  tggtccagg  cttccatgc  gctccccaa  1380
atgtgaagc  aaactactt  aagggtctt  ctcatgtac  taacaggct  cccaagcct  1440
tactcttgc  agagctgcc  acggccctg  cctgccctg  ctgtgtggt  cagctctcc  1500
ccctcagct  ccttcagcc  cttctactg  aagcacccc  agtcatgag  cttcacgtg  1560
acaccctcg  caccaagtt  ctgaacctc  gctctagcc  ttccatggc  gtccggatc  1620
ccgcactgc  gtgcatgca  gctctcact  gcctgccca  ccctgtgct  ctgccgtac  1680
aaccacagg  gattcgggc  ttagccaaa  ccctggatg  caagaagag  ctggtgcgc  1740
aggaagcag  gtcagccag  ggggagtgg  ttctgttgg  gagccctgg  agctgagcc  1800
tcagtcctg  cctagactg  tctgacaat  taacctggg  ttactaact  ttgagccat  1860
ttccccaaa  cagggaaac  actggtctc  gactgcctt  cccacagac  cagcacaaa  1920
gctaggcct  tgttgcatg  ctgtacaaa  aacataaga  tccatattt  tagtggatt  1980
gtaaaataa  tgtgtgtga  acacttgcg  ttgaagaaa  atctagggt  ctgggtctc  2040
tgcatttat  tgtcagaaa  ggggcgata  gctgctgag  ggtgagtgc  tatgagtgt  2100
gccctgagg  ccagggctg  cagatgttg  ctacctgct  aagaataaa  atttctttt  2160
gtaaaaaaa  aaaaaaaaa  a  2181



<210> 4349
<211> 293
<212> PRT
<213> Homo sapiens
<308> BC009396
<400> 4349

Met Arg Glu Leu Leu Glu Leu Ser Cys Cys His Ser Cys Pro Phe Ser 
  1               5                  10                  15
Ser Thr Ala Ala Ala Lys Cys Phe Ala Gly Leu Leu Asn Lys His Pro 
             20                  25                  30
Ala Gly Gln Gln Leu Asp Glu Phe Leu Gln Leu Ala Val Asp Lys Val 
         35                  40                  45
Glu Ala Gly Leu Gly Ser Gly Pro Cys Arg Ser Gln Ala Phe Thr Leu 
     50                  55                  60
Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro Leu Ser 
 65                  70                  75                  80
Ser Cys Leu Thr Ala Arg Leu Met Gly Leu Leu Ser Asp Pro Glu Leu 
                 85                  90                  95
Gly Pro Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp Cys Thr 
             100                105                110
Asp Val Leu Thr Arg Ala Gly His Ala Glu Val Arg Ile Met Phe Arg 
         115                120                125
Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly Phe His 
     130                135                140
Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu Ser His 
 145                150                155                160
Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu Pro Thr 
                 165                170                175
Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Cys Val Val 
             180                185                190
Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu Ala Pro 
         195                200                205
Gln Val Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe Leu Asn 
     210                215                220
Leu Ser Ser Ser Pro Ser Met Ala Val Arg Ile Ala Ala Leu Gln Cys 
 225                230                235                240
Met His Ala Leu Thr Arg Leu Pro Thr Pro Val Leu Leu Pro Tyr Lys 
                 245                250                255
Pro Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys Lys Arg 
             260                265                270
Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe Leu Leu 
         275                280                285
Gly Ser Pro Gly Ser 
     290



<210> 4350
<211> 595
<212> DNA
<213> Rattus norvegicus
<308> AA799566
<400> 4350

gcccattac  aaagtcttt  ttcgctggc  ggtgcattc  tgtaacaca  atccctagt  60
ctcaaggtc  cactcaact  gattggccc  tcagcagca  agccacgta  tgtcctgat  120
ggacacagg  gagcccaag  tcttttcct  aaatacaag  ctcagtctc  tcaacaatc  180
attagaaat  atggctctt  gaaaagagt  ttgcacagc  atgcaggag  ggcccagca  240
ttgtactgc  tccatgggc  ggcaggcca  tgggtggtc  tgccttgtg  gatggctca  300
tattagtac  tgcgggtta  attgtcagg  gggtttagg  gaggaccaa  ggctcagct  360
ccagggctc  ccagtagga  ccattctcc  cttgctgac  ctgcttcct  gcgcacaag  420
ctcttcttg  catccagag  cttggctaa  gctcggatc  cctgagatt  gaatggcag  480
aacacagaa  tggggtacc  agtgagagc  tgcatacac  gcagagcag  aatccggac  540
gccattgaa  gactggaac  gaaggtcag  agtttcgtg  caagttatc  catga  595



<210> 4351
<211> 1031
<212> PRT
<213> Rattus norvegicus
<308> AAK52670
<400> 4351

Met Ala Ala Ala Thr Gly Leu Glu Glu Ala Val Ala Pro Met Gly Ala 
  1               5                  10                  15
Leu Cys Gly Leu Val Gln Asp Phe Val Met Gly Gln Gln Glu Gly Pro 
             20                  25                  30
Ala Asp Gln Val Ala Ala Asp Val Lys Ser Gly Gly Tyr Thr Val Leu 
         35                  40                  45
Gln Val Val Glu Ala Leu Gly Ser Ser Leu Glu Asn Ala Glu Pro Arg 
     50                  55                  60
Thr Arg Ala Arg Gly Ala Gln Leu Leu Ser Gln Val Leu Leu Gln Cys 
 65                  70                  75                  80
His Ser Leu Leu Ser Glu Lys Glu Val Val His Leu Ile Leu Phe Tyr 
                 85                  90                  95
Glu Asn Arg Leu Lys Asp His His Leu Val Val Pro Ser Val Leu Gln 
             100                105                110
Gly Leu Arg Ala Leu Ser Met Ser Val Ala Leu Pro Pro Gly Leu Ala 
         115                120                125
Val Ser Val Leu Lys Ala Ile Phe Gln Glu Val His Val Gln Ser Leu 
     130                135                140
Leu Gln Val Asp Arg His Thr Val Phe Ser Ile Ile Thr Asn Phe Met 
 145                150                155                160
Arg Ser Arg Glu Glu Glu Leu Lys Gly Leu Gly Ala Asp Phe Thr Phe 
                 165                170                175
Gly Phe Ile Gln Val Met Asp Gly Glu Lys Asp Pro Arg Asn Leu Leu 
             180                185                190
Leu Ala Phe Arg Ile Val His Asp Leu Ile Ser Lys Asp Tyr Ser Leu 
         195                200                205
Gly Pro Phe Val Glu Glu Leu Phe Glu Val Thr Ser Cys Tyr Phe Pro 
     210                215                220
Ile Asp Phe Thr Pro Pro Pro Asn Asp Pro Tyr Gly Val Gln Arg Glu 
 225                230                235                240
Asp Leu Ile Leu Ser Leu Arg Ala Val Leu Ala Ser Thr Pro Arg Phe 
                 245                250                255
Ala Glu Phe Leu Leu Pro Leu Leu Ile Glu Lys Val Asp Ser Glu Ile 
             260                265                270
Leu Ser Ala Lys Leu Asp Ser Leu Gln Thr Leu Asn Ala Cys Cys Ala 
         275                280                285
Val Tyr Gly Gln Lys Glu Leu Lys Asp Phe Leu Pro Ser Leu Trp Ala 
     290                295                300
Ser Ile Arg Arg Glu Val Phe Gln Thr Ala Ser Glu Arg Val Glu Ala 
 305                310                315                320
Glu Gly Leu Ala Ala Leu His Ser Leu Thr Ala Cys Leu Ser Cys Ser 
                 325                330                335
Val Leu Arg Ala Asp Ala Glu Asp Leu Leu Gly Ser Phe Leu Ser Asn 
             340                345                350
Ile Leu Gln Asp Cys Arg His His Leu Cys Glu Pro Asp Met Lys Leu 
         355                360                365
Val Trp Pro Ser Ala Lys Leu Leu Gln Ala Ala Ala Gly Ala Ser Ala 
     370                375                380
Arg Ala Cys Glu His Leu Thr Ser Asn Val Leu Pro Leu Leu Leu Glu 
 385                390                395                400
Gln Phe His Lys His Ser Gln Ser Asn Gln Arg Arg Thr Ile Leu Glu 
                 405                410                415
Met Ile Leu Gly Phe Leu Lys Leu Gln Gln Lys Trp Ser Tyr Glu Asp 
             420                425                430
Arg Asp Glu Arg Pro Leu Ser Ser Phe Lys Asp Gln Leu Cys Ser Leu 
         435                440                445
Val Phe Met Ala Leu Thr Asp Pro Ser Thr Gln Leu Gln Leu Val Gly 
     450                455                460
Ile Arg Thr Leu Thr Val Leu Gly Ala Gln Pro Gly Leu Leu Ser Ala 
 465                470                475                480
Glu Asp Leu Glu Leu Ala Val Gly His Leu Tyr Arg Leu Thr Phe Leu 
                 485                490                495
Glu Glu Asp Ser Gln Ser Cys Arg Val Ala Ala Leu Glu Ala Ser Gly 
             500                505                510
Thr Leu Ala Thr Leu Tyr Pro Gly Ala Phe Ser Arg His Leu Leu Pro 
         515                520                525
Lys Leu Ala Glu Glu Leu His Lys Gly Glu Ser Asp Val Ala Arg Ala 
     530                535                540
Asp Gly Pro Thr Lys Cys Ser Arg His Phe Arg Cys Leu Gln Ala Leu 
 545                550                555                560
Ser Ala Val Ser Thr His Pro Ser Ile Val Lys Glu Thr Leu Pro Leu 
                 565                570                575
Leu Leu Gln His Leu Cys Gln Ala Asn Lys Gly Asn Met Val Thr Glu 
             580                585                590
Ser Ser Glu Val Val Ala Val Cys Gln Ser Leu Gln Gln Val Ala Glu 
         595                600                605
Lys Cys Gln Gln Asp Pro Glu Ser Tyr Trp Tyr Phe His Lys Thr Ala 
     610                615                620
Val Pro Cys Leu Phe Ala Leu Ala Val Gln Ala Ser Met Pro Glu Lys 
 625                630                635                640
Glu Ser Ser Val Leu Arg Lys Val Leu Leu Glu Asp Glu Val Leu Ala 
                 645                650                655
Ala Leu Ala Ser Val Ile Gly Thr Ala Thr Thr His Leu Ser Pro Glu 
             660                665                670
Leu Ala Ala Gln Ser Val Thr Cys Val Val Pro Leu Phe Leu Asp Gly 
         675                680                685
Asn Thr Ser Phe Leu Pro Glu Asn Ser Phe Pro Asp Gln Phe Gln Pro 
     690                695                700
Phe Gln Asp Gly Ser Ser Gly Gln Arg Arg Leu Val Ala Leu Leu Thr 
 705                710                715                720
Ala Phe Val Cys Ser Leu Pro Arg Asn Val Glu Ile Pro Gln Leu Asn 
                 725                730                735
Arg Leu Met Arg Glu Leu Leu Lys Gln Ser Cys Gly His Ser Cys Pro 
             740                745                750
Phe Ser Ser Thr Ala Ala Thr Lys Cys Phe Ala Gly Leu Leu Asn Lys 
         755                760                765
Gln Pro Pro Gly Gln Gln Leu Glu Glu Phe Leu Gln Leu Ala Val Gly 
     770                775                780
Thr Val Glu Ala Gly Leu Ala Ser Glu Ser Ser Arg Asp Gln Ala Phe 
 785                790                795                800
Thr Leu Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro 
                 805                810                815
Leu Ser Ala Cys Leu Thr Thr Arg Leu Met Gly Leu Leu Ser Asp Pro 
             820                825                830
Glu Leu Gly Cys Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp 
         835                840                845
Cys Thr Asp Val Leu Thr Arg Ala Gly His Ala Asp Val Arg Ile Met 
     850                855                860
Phe Arg Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly 
 865                870                875                880
Phe His Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu 
                 885                890                895
Ser His Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu 
             900                905                910
Pro Thr Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Ser 
         915                920                925
Val Val Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu 
     930                935                940
Ala Pro Gln Ile Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe 
 945                950                955                960
Leu Asn Leu Ser Ser Ser Tyr Ser Met Ala Val Arg Ile Ala Ala Leu 
                 965                970                975
Gln Cys Met His Ala Leu Thr Arg Leu Pro Thr Ser Val Leu Leu Pro 
             980                985                990
Tyr Lys Ser Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys 
         995                1000                1005
Lys Arg Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe 
     1010                1015                1020
Leu Leu Gly Ser Pro Gly Ser 
 1025                1030



<210> 4352
<211> 2181
<212> DNA
<213> Homo sapiens
<308> AK025496
<400> 4352

aatggagct  tgaagacaa  gatcaaagg  ctctgaatg  cttcaagga  cagctgtgc  60
cactggtat  catggctct  acagacccc  gcacccagc  tcagcttgt  ggcatccgt  120
cactgacag  cttgggtgc  cagccagat  tcctatctt  tgaggactt  gagctggca  180
tgggtcacc  gtacagact  agcttcctg  aggaggatt  ccagagttg  agggtggca  240
cactggaag  atcaggaac  ctggctgct  tctaccctg  ggccttcag  agccacctc  300
tacccaagc  cgctgagga  ctgcgtgta  gggagtcaa  tttgactaa  ggagatgag  360
ccacccaat  ctcccggca  ctgtgctgt  tgcaagcct  gtcagctgt  tcaacacat  420
ccagcatcg  caaggagac  ctgcctctg  tgctgcagc  tctctggca  gtgaacaga  480
ggaatatgg  tgcacaatc  agtgacgtt  ttgctgtct  tcagagcct  agacagatg  540
cagaaaaat  tcagcagga  cctgagagt  gctggtatt  ccaccagac  gctatacct  600
gcctgcttg  cttggctgt  caggcctct  tgccagaga  ggagccctc  gttctgaga  660
aagtactat  ggaggatga  gtgttggct  ccatggtgt  tgtcattgg  actgctaca  720
cccacctga  ccctgagtt  gctgcccag  gtgtgacac  cattgtgcc  ctcttcttg  780
atggcaacg  gtcctttct  cctgaaaac  gcttcccga  cagattcca  ccattccag  840
atggctcct  agggcagag  cggctgatt  cactgctta  ggcctttgt  tgctccctg  900
ctcgaaatg  ggaaatccc  cagctgaac  aactcatgc  ggagctttt  gaactgagc  960
gctgccaca  ctgcccctt  tcttccacc  ctgctgcca  gtgctttgc  ggactcctc  1020
acaagcacc  tgcagggca  cagctggat  aattcctac  gctagctgt  gacaaagtg  1080
aggctggcc  gggctctgg  ccctgtcgt  gtcaggcct  cactcttct  ctctgggta  1140
taaaggccc  agtgctcag  taccatcct  tcagctcct  ccttacagc  cggctcatg  1200
gcctcctga  tgacccaga  ttaggtcca  cagcagctg  tggcttctc  ctgctcatg  1260
ctgactgca  tgatgtgct  actcgtgct  gccatgctg  agtgcggat  atgttccgc  1320
agcggttct  cacagataa  gtgcctgct  tggtccagg  cttccatgc  gctccccaa  1380
atgtgaagc  aaactactt  aagggtctt  ctcatgtac  taacaggct  cccaagcct  1440
tactcttgc  agagctgcc  acggccctg  cctgccctg  ctgtgtggt  cagctctcc  1500
ccctcagct  ccttcagcc  cttctactg  aagcacccc  agtcatgag  cttcacgtg  1560
acaccctcg  caccaagtt  ctgaacctc  gctctagcc  ttccatggc  gtccggatc  1620
ccgcactgc  gtgcatgca  gctctcact  gcctgccca  ccctgtgct  ctgccgtac  1680
aaccacagg  gattcgggc  ttagccaaa  ccctggatg  caagaagag  ctggtgcgc  1740
aggaagcag  gtcagccag  ggggagtgg  ttctgttgg  gagccctgg  agctgagcc  1800
tcagtcctg  cctagactg  tctgacaat  taacctggg  ttactaact  ttgagccat  1860
ttccccaaa  cagggaaac  actggtctc  gactgcctt  cccacagac  cagcacaaa  1920
gctaggcct  tgttgcatg  ctgtacaaa  aacataaga  tccatattt  tagtggatt  1980
gtaaaataa  tgtgtgtga  acacttgcg  ttgaagaaa  atctagggt  ctgggtctc  2040
tgcatttat  tgtcagaaa  ggggcgata  gctgctgag  ggtgagtgc  tatgagtgt  2100
gccctgagg  ccagggctg  cagatgttg  ctacctgct  aagaataaa  atttctttt  2160
gtaaaaaaa  aaaaaaaaa  a  2181



<210> 4353
<211> 293
<212> PRT
<213> Homo sapiens
<308> BC009396
<400> 4353

Met Arg Glu Leu Leu Glu Leu Ser Cys Cys His Ser Cys Pro Phe Ser 
  1               5                  10                  15
Ser Thr Ala Ala Ala Lys Cys Phe Ala Gly Leu Leu Asn Lys His Pro 
             20                  25                  30
Ala Gly Gln Gln Leu Asp Glu Phe Leu Gln Leu Ala Val Asp Lys Val 
         35                  40                  45
Glu Ala Gly Leu Gly Ser Gly Pro Cys Arg Ser Gln Ala Phe Thr Leu 
     50                  55                  60
Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro Leu Ser 
 65                  70                  75                  80
Ser Cys Leu Thr Ala Arg Leu Met Gly Leu Leu Ser Asp Pro Glu Leu 
                 85                  90                  95
Gly Pro Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp Cys Thr 
             100                105                110
Asp Val Leu Thr Arg Ala Gly His Ala Glu Val Arg Ile Met Phe Arg 
         115                120                125
Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly Phe His 
     130                135                140
Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu Ser His 
 145                150                155                160
Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu Pro Thr 
                 165                170                175
Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Cys Val Val 
             180                185                190
Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu Ala Pro 
         195                200                205
Gln Val Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe Leu Asn 
     210                215                220
Leu Ser Ser Ser Pro Ser Met Ala Val Arg Ile Ala Ala Leu Gln Cys 
 225                230                235                240
Met His Ala Leu Thr Arg Leu Pro Thr Pro Val Leu Leu Pro Tyr Lys 
                 245                250                255
Pro Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys Lys Arg 
             260                265                270
Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe Leu Leu 
         275                280                285
Gly Ser Pro Gly Ser 
     290



<210> 4354
<211> 588
<212> DNA
<213> Rattus norvegicus
<308> AA799575
<400> 4354

gctaatgcc  ggaaaacac  ttattacac  aattacatt  agattctga  aaatagtgt  60
ctaacagtg  aaccatcta  aaataagac  tcccggaaa  acaccaact  aggagaaat  120
taaaaaaag  atttaaata  agacttttt  aaatttccc  cattgcaat  taatgttag  180
gattttaaa  aaatagaag  agatttagc  gcttttcgt  gtgtggcag  ttggttccc  240
tcactgcca  aggctgaga  tgctgaaca  gaaaggcac  aatgaaaga  actggcaat  300
ggtgtggac  gggaaaata  tgtgttcaa  cagagaata  ggctattta  atccaccaa  360
taaaacgtc  ccaaatgtg  atgacctaa  tttccctcg  gggttggag  gctaccttg  420
aaaaggagg  gggcttctc  acccaagtt  atagaaaga  aatgcacgg  cgtgaccgg  480
gggggaacc  tcacctaga  acaaaacca  cgggcccaa  gaattaaat  ggtgtgtaa  540
cccaacgga  gagtaaatt  aaatcattg  aaaaaattt  cacccctn  588



<210> 4355
<211> 976
<212> PRT
<213> Rattus norvegicus
<308> P14925
<400> 4355

Met Ala Gly Arg Ala Arg Ser Gly Leu Leu Leu Leu Leu Leu Gly Leu 
  1               5                  10                  15
Leu Ala Leu Gln Ser Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val 
             20                  25                  30
Phe Lys Arg Phe Lys Glu Thr Thr Arg Ser Phe Ser Asn Glu Cys Leu 
         35                  40                  45
Gly Thr Ile Gly Pro Val Thr Pro Leu Asp Ala Ser Asp Phe Ala Leu 
     50                  55                  60
Asp Ile Arg Met Pro Gly Val Thr Pro Lys Glu Ser Asp Thr Tyr Phe 
 65                  70                  75                  80
Cys Met Ser Met Arg Leu Pro Val Asp Glu Glu Ala Phe Val Ile Asp 
                 85                  90                  95
Phe Lys Pro Arg Ala Ser Met Asp Thr Val His His Met Leu Leu Phe 
             100                105                110
Gly Cys Asn Met Pro Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu 
         115                120                125
Gly Thr Cys Thr Asp Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn 
     130                135                140
Ala Pro Pro Thr Arg Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly 
 145                150                155                160
Glu Thr Gly Ser Lys Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile 
                 165                170                175
Ser Ala Phe Arg Asp Asn His Lys Asp Cys Ser Gly Val Ser Val His 
             180                185                190
Leu Thr Arg Val Pro Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met 
         195                200                205
Ser Val Asp Thr Val Ile Pro Pro Gly Glu Lys Val Val Asn Ala Asp 
     210                215                220
Ile Ser Cys Gln Tyr Lys Met Tyr Pro Met His Val Phe Ala Tyr Arg 
 225                230                235                240
Val His Thr His His Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg 
                 245                250                255
Asn Gly Gln Trp Thr Leu Ile Gly Arg Gln Asn Pro Gln Leu Pro Gln 
             260                265                270
Ala Phe Tyr Pro Val Glu His Pro Val Asp Val Thr Phe Gly Asp Ile 
         275                280                285
Leu Ala Ala Arg Cys Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr 
     290                295                300
His Ile Gly Gly Thr Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met 
 305                310                315                320
Tyr Tyr Met Glu Ala Lys Tyr Ala Leu Ser Phe Met Thr Cys Thr Lys 
                 325                330                335
Asn Val Ala Pro Asp Met Phe Arg Thr Ile Pro Ala Glu Ala Asn Ile 
             340                345                350
Pro Ile Pro Val Lys Pro Asp Met Val Met Met His Gly His His Lys 
         355                360                365
Glu Ala Glu Asn Lys Glu Lys Ser Ala Leu Met Gln Gln Pro Lys Gln 
     370                375                380
Gly Glu Glu Glu Val Leu Glu Gln Gly Asp Phe Tyr Ser Leu Leu Ser 
 385                390                395                400
Lys Leu Leu Gly Glu Arg Glu Asp Val His Val His Lys Tyr Asn Pro 
                 405                410                415
Thr Glu Lys Thr Glu Ser Gly Ser Asp Leu Val Ala Glu Ile Ala Asn 
             420                425                430
Val Val Gln Lys Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala 
         435                440                445
Glu His Glu Glu Trp Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His 
     450                455                460
Arg Phe His Gln Leu Glu Ser Thr Leu Arg Pro Ala Glu Ser Arg Ala 
 465                470                475                480
Phe Ser Phe Gln Gln Pro Gly Glu Gly Pro Trp Glu Pro Glu Pro Ser 
                 485                490                495
Gly Asp Phe His Val Glu Glu Glu Leu Asp Trp Pro Gly Val Tyr Leu 
             500                505                510
Leu Pro Gly Gln Val Ser Gly Val Ala Leu Asp Ser Lys Asn Asn Leu 
         515                520                525
Val Ile Phe His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp 
     530                535                540
Ser Lys Phe Val Tyr Gln Gln Arg Gly Leu Gly Pro Ile Glu Glu Asp 
 545                550                555                560
Thr Ile Leu Val Ile Asp Pro Asn Asn Ala Glu Ile Leu Gln Ser Ser 
                 565                570                575
Gly Lys Asn Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Thr Asp 
             580                585                590
Gly Asn Tyr Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu 
         595                600                605
Asp Pro His Ser Lys Glu Gly Pro Leu Leu Ile Leu Gly Arg Ser Met 
     610                615                620
Gln Pro Gly Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala 
 625                630                635                640
Val Glu Pro Ser Thr Gly Ala Val Phe Val Ser Asp Gly Tyr Cys Asn 
                 645                650                655
Ser Arg Ile Val Gln Phe Ser Pro Ser Gly Lys Phe Val Thr Gln Trp 
             660                665                670
Gly Glu Glu Ser Ser Gly Ser Ser Pro Arg Pro Gly Gln Phe Ser Val 
         675                680                685
Pro His Ser Leu Ala Leu Val Pro His Leu Asp Gln Leu Cys Val Ala 
     690                695                700
Asp Arg Glu Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu 
 705                710                715                720
Phe Val Arg Glu Ile Lys His Ala Ser Phe Gly Arg Asn Val Phe Ala 
                 725                730                735
Ile Ser Tyr Ile Pro Gly Phe Leu Phe Ala Val Asn Gly Lys Pro Tyr 
             740                745                750
Phe Gly Asp Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Ser 
         755                760                765
Gly Glu Ile Ile Asp Val Phe Lys Pro Val Arg Lys His Phe Asp Met 
     770                775                780
Pro His Asp Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp 
 785                790                795                800
Ala His Thr Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Met Glu 
                 805                810                815
His Arg Ser Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu 
             820                825                830
Ala Glu Ala Val Val Glu Pro Lys Val Glu Asn Lys Pro Thr Ser Ser 
         835                840                845
Glu Leu Gln Lys Met Gln Glu Lys Gln Lys Leu Ser Thr Glu Pro Gly 
     850                855                860
Ser Gly Val Ser Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val 
 865                870                875                880
Leu Val Leu Leu Ala Ile Val Met Phe Ile Arg Trp Lys Lys Ser Arg 
                 885                890                895
Ala Phe Gly Asp His Asp Arg Lys Leu Glu Ser Ser Ser Gly Arg Val 
             900                905                910
Leu Gly Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn 
         915                920                925
Phe Phe Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Val 
     930                935                940
Ser Thr Glu Gly Ser Asp Gln Glu Lys Asp Glu Asp Asp Gly Thr Glu 
 945                950                955                960
Ser Glu Glu Glu Tyr Ser Ala Pro Leu Pro Lys Pro Ala Pro Ser Ser 
                 965                970                975



<210> 4356
<211> 1417
<212> DNA
<213> Homo sapiens
<308> AF035320
<400> 4356

gtcggatcc  gtgttttaa  actgacacc  aagaatttg  gagagagat  aagcattca  60
catttggaa  aaatgtatt  gcaatttca  atataccag  cttgctctt  gcagtgaat  120
ggaagcctc  ttttgggga  caagaacct  tacaaggat  tgtgatgaa  ttttccaat  180
gggaaatta  agacatctt  aagccagtg  gcaagcact  tgatatgcc  catgatatt  240
ttgcatctg  agatgggac  gtgtacatt  gagatgctc  taccaacac  gtgtggaag  300
tcaccttga  tgagaaatt  gaacatcga  cagttaaaa  ggctggcat  gaggtccag  360
aaatcaaag  agccgaggc  gttgttgaa  ccaaaatgg  gaacaaacc  acctcctca  420
aattgcaga  gatgcaaga  aaacagaaa  tgatcaaag  gccaggctc  ggagtgcct  480
ttgttctca  tacaaccct  ctggttatt  cggtggttg  cctgctggc  attgccata  540
ttattcggt  gaaaaaatc  agggccttt  gaggaaagg  aagtggagg  ttaaacctt  600
gtaatttct  tgcaagccg  aagggctac  gtcgaaaag  gtttgaccg  cttagcact  660
agggcagtg  ccaagagaa  gaggatgat  gaagtgaat  agaagagga  tattcagca  720
ctctgcctg  gctcgcacc  tcctcctcc  gaaaaccaa  ctttgattt  gattgagta  780
gatttaccc  gaatgtcag  ttcctttcc  tttagcacg  ttaaagttc  gtgtattta  840
ttgtaaact  tactagtct  tgtgggact  tacacactt  atttacttc  ttttggtta  900
gttggcttc  gtttctagt  gaggagttt  ctaaaagtt  ataacagtg  cattgtctt  960
atatgaaca  agactagag  aaccgtcct  tttttccat  ataattcta  tctaacaat  1020
gaagatttg  ccatttaca  ttttgagac  ttttggtgg  tgtaaataa  cccattctt  1080
gcttgaaca  agtattttc  caatagcac  ttcattgcc  gtgtctttc  ttggtgcct  1140
tcctgttca  cattcttag  ctgtggcaa  aaagagaaa  tttgtgcta  atgacgaca  1200
agctgctaa  tctcctatt  ttttaaaat  actaacatt  tattgcaat  aaggaaata  1260
aaaagtctc  atttaaatt  ttttttaaa  tttcttcag  tggtgtgtt  ttgggatgt  1320
ttattttta  atggttaca  tgttagaac  ctattttca  aatctgaat  taatttgtg  1380
aataaagtg  tttcagagc  aaaaaaaaa  aaaaaaa  1417



<210> 4357
<211> 974
<212> PRT
<213> Homo sapiens
<308> P19021
<400> 4357

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
  1               5                  10                  15
Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
             20                  25                  30
Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
         35                  40                  45
Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
     50                  55                  60
Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
 65                  70                  75                  80
Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                 85                  90                  95
Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
             100                105                110
Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
         115                120                125
Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
     130                135                140
Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
 145                150                155                160
Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                 165                170                175
Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
             180                185                190
Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
         195                200                205
Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
     210                215                220
Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
 225                230                235                240
Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                 245                250                255
Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
             260                265                270
Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
         275                280                285
Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
     290                295                300
Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
 305                310                315                320
Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                 325                330                335
Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
             340                345                350
Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
         355                360                365
Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
     370                375                380
Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
 385                390                395                400
Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                 405                410                415
Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
             420                425                430
Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
         435                440                445
Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
     450                455                460
Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
 465                470                475                480
Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                 485                490                495
His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
             500                505                510
Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
         515                520                525
His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
     530                535                540
Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
 545                550                555                560
Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Glu Lys Asn 
                 565                570                575
Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
             580                585                590
Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
         595                600                605
Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
     610                615                620
Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
 625                630                635                640
Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                 645                650                655
Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
             660                665                670
Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
         675                680                685
Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
     690                695                700
Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
 705                710                715                720
Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                 725                730                735
Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
             740                745                750
Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
         755                760                765
Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
     770                775                780
Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
 785                790                795                800
Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                 805                810                815
Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala 
             820                825                830
Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln 
         835                840                845
Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val 
     850                855                860
Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu 
 865                870                875                880
Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly 
                 885                890                895
Ala Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly 
             900                905                910
Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe 
         915                920                925
Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr 
     930                935                940
Glu Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu 
 945                950                955                960
Glu Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                 965                970



<210> 4358
<211> 523
<212> DNA
<213> Rattus norvegicus
<308> AA799593
<400> 4358

aaaagatag  tgttctcca  cctcattga  ttaaccctt  tggaatata  cacttctaa  60
ctaaaaaca  acatcaaga  aaaggttag  ccagtggga  attcaaaat  tcttcagaa  120
gtcttacat  ggctacgtc  actgctctg  tttcggcaa  aatacagag  agagctgct  180
tctaaacgg  ctccaaatt  cctccagag  caggtctca  actgccggg  acactggat  240
gcagttggc  ggtaacagc  agccaggca  ttcaagctg  ctgtctgtc  gtctgtcgg  300
tactgcaga  ggagaaagt  gtgtcccct  aacctgcct  catgacaat  tactaaagt  360
gttcttccc  cttcgagcc  ctttggtac  aaaacttca  ttggtttca  ctgttaccc  420
tttcaaatt  aggagtttt  ggtctcggg  accacacta  ccaattcca  agcattggc  480
gcttcggag  aaaactaac  ggagttcaa  tttgtccaa  ctc  523



<210> 4359
<211> 183
<212> PRT
<213> Rattus norvegicus
<308> AAH08517
<400> 4359

Met Ser Ser Pro Ser Pro Gly Lys Arg Arg Met Asp Thr Asp Val Val 
  1               5                  10                  15
Lys Leu Ile Glu Ser Lys His Glu Val Thr Ile Leu Gly Gly Leu Asn 
             20                  25                  30
Glu Phe Val Val Lys Phe Tyr Gly Pro Gln Gly Thr Pro Tyr Glu Gly 
         35                  40                  45
Gly Val Trp Lys Val Arg Val Asp Leu Pro Asp Lys Tyr Pro Phe Lys 
     50                  55                  60
Ser Pro Ser Ile Gly Phe Met Asn Lys Ile Phe His Pro Asn Ile Asp 
 65                  70                  75                  80
Glu Ala Ser Gly Thr Val Cys Leu Asp Val Ile Asn Gln Thr Trp Thr 
                 85                  90                  95
Ala Leu Tyr Asp Leu Thr Asn Ile Phe Glu Ser Phe Leu Pro Gln Leu 
             100                105                110
Leu Ala Tyr Pro Asn Pro Ile Asp Pro Leu Asn Gly Asp Ala Ala Ala 
         115                120                125
Met Tyr Leu His Arg Pro Glu Glu Tyr Lys Gln Lys Ile Lys Glu Tyr 
     130                135                140
Ile Gln Lys Tyr Ala Thr Glu Glu Ala Leu Lys Glu Gln Glu Glu Gly 
 145                150                155                160
Thr Gly Asp Ser Ser Ser Glu Ser Ser Met Ser Asp Phe Ser Glu Asp 
                 165                170                175
Glu Ala Gln Asp Met Glu Leu 
             180



<210> 4360
<211> 1579
<212> DNA
<213> Homo sapiens
<308> NM_003344
<400> 4360

ccgggccgt  acagacggc  ggcagagga  gggagagag  cggcggcga  accatgtca  60
ctcccagtc  gggcaagag  cggatggac  cggacgtgg  caagctcat  gagagtaaa  120
atgaggtta  gatcctggg  ggacttaat  aatttgtag  gaagtttta  ggaccacaa  180
gaacaccat  tgaaggcgg  gtatggaaa  ttagagtgg  cctacctga  aaataccct  240
tcaaatctc  atctatagg  ttcatgaat  aaattttcc  tcccaacat  gatgaagcg  300
caggaactg  gtgtctaga  gtaattaat  aaacttgga  agctctcta  gatcttacc  360
atatatttg  gtccttcct  cctcagtta  tggcctatc  taaccccat  gatcctctc  420
atggtgacg  tgcagccat  tacctccac  gaccagaag  atacaagca  aaaattaaa  480
agtacatcc  gaaatacgc  acggaggag  cgctgaaag  acaggaaga  ggtaccggg  540
acagctcat  ggagagctc  atgtctgac  tttccgaag  tgaggccca  gatatggag  600
tgtagtaga  aaagcacct  cttttcaga  agactatta  ttcctaacc  tgagaagca  660
actataata  tcatattta  acaaagcaa  tttttttat  actaaacaa  gtttttatg  720
ataatagca  tgatatata  atattatat  tcacccttt  gatcttgat  tcttggtca  780
ttctcaacc  gaggtgcat  gcatattcc  acattccat  tggtagcaa  atgcggtct  840
aatgcatgc  ttcatgagt  catgtggcc  agtcagcct  tgtgctact  aactgtcga  900
ggaaatagc  gctctgata  gtagatgtg  gtaaaaaga  caggaaaaa  ttgcttctt  960
tattggttt  caaagaaac  aaccaaacc  accagctct  ggatgtgaa  ataaaatag  1020
gcttttttg  aatggagag  aaaaacttg  ggaggaaga  gcctgctgt  ggggcatcg  1080
agccagcca  gtaagaatc  gagctgctc  ttcctgtga  tcctaggtg  ccctatgtc  1140
tctgtggag  tacagtata  agcagggag  taattaaga  tattaaaac  taaaaccat  1200
ttttgactc  gattttaag  acattttta  atgtcagtt  ctgcccttc  cactaccag  1260
ccctgcagc  acagtgttc  gttggagaa  cttggggaa  tgttttctg  accagttct  1320
tttcttggg  tagagcgtg  aatccagac  tgtttttga  aggacagca  aggaggaga  1380
aagtgactg  gacgatgct  cctctcatc  aaaacacat  cagagtcac  tcctcatcc  1440
agtgtttgg  agtttgaga  cgctaccct  aacttaaga  ctttaaata  gagggttgt  1500
tttctgggg  ggttatttt  ttggtgtgt  tgtgtgtgt  ttgtgctta  aaaggttgc  1560
gatttcatc  tcacctacc  1579



<210> 4361
<211> 183
<212> PRT
<213> Homo sapiens
<308> P37286
<400> 4361

Met Ser Ser Pro Ser Pro Gly Lys Arg Arg Met Asp Thr Asp Val Val 
  1               5                  10                  15
Lys Leu Ile Glu Ser Lys His Glu Val Thr Ile Leu Gly Gly Leu Asn 
             20                  25                  30
Glu Phe Val Val Lys Phe Tyr Gly Pro Gln Gly Thr Pro Tyr Glu Gly 
         35                  40                  45
Gly Val Trp Lys Val Arg Val Asp Leu Pro Asp Lys Tyr Pro Phe Lys 
     50                  55                  60
Ser Pro Ser Ile Gly Phe Met Asn Lys Ile Phe His Pro Asn Ile Asp 
 65                  70                  75                  80
Glu Ala Ser Gly Thr Val Cys Leu Asp Val Ile Asn Gln Thr Trp Thr 
                 85                  90                  95
Ala Leu Tyr Asp Leu Thr Asn Ile Phe Glu Ser Phe Leu Pro Gln Leu 
             100                105                110
Leu Ala Tyr Pro Asn Pro Ile Asp Pro Leu Asn Gly Asp Ala Ala Ala 
         115                120                125
Met Tyr Leu His Arg Pro Glu Glu Tyr Lys Gln Lys Ile Lys Glu Tyr 
     130                135                140
Ile Gln Lys Tyr Ala Thr Glu Glu Ala Leu Lys Glu Gln Glu Glu Gly 
 145                150                155                160
Thr Gly Asp Ser Ser Ser Glu Ser Ser Met Ser Asp Phe Ser Glu Asp 
                 165                170                175
Glu Ala Gln Asp Met Glu Leu 
             180



<210> 4362
<211> 591
<212> DNA
<213> Rattus norvegicus
<308> AA799600
<400> 4362

cacagtctg  gcagctttt  tttcaacag  gaagtaata  gatctatat  cagtctaaa  60
ccactagaa  aggtgagta  aaaggaccc  tggtccatc  gggtccaac  aggggcggt  120
gcacatgcc  ttactccca  cacttggga  gtggaggca  gcagatctg  gagtttgag  180
ccagcctgg  tgacagtga  ttccaggca  gccagagct  catactgag  ccctgtctc  240
aaacaaaag  ctatggagt  atatgaatg  tggggccgg  caagcatcg  acctggcgt  300
cagagcagg  cctgggcat  tctctggta  atgtaggag  gaggcctta  gaaagaccc  360
gcactgagc  gaggcacag  ggacactgc  tacctgttt  agctgtcta  ctgtctcca  420
aggacaggc  gacattcca  tgccatcat  gtaggtcca  cctgactta  acacccaga  480
gggatcaag  ctggcctgc  ttctgtaag  atgttcaga  cttcacggt  ctattcaga  540
cccccgaga  tagccggtc  cgggagatc  ccagtggag  gtaaatgtc  t  591



<210> 4363
<211> 409
<212> PRT
<213> Rattus norvegicus
<308> P43035
<400> 4363

Val Leu Ser Gln Arg Gln Arg Asp Glu Leu Asn Arg Ala Ile Ala Asp 
  1               5                  10                  15
Tyr Leu Arg Ser Asn Gly Tyr Glu Glu Ala Tyr Ser Val Phe Lys Lys 
             20                  25                  30
Glu Ala Glu Leu Asp Met Asn Glu Glu Leu Asp Lys Lys Tyr Ala Gly 
         35                  40                  45
Leu Leu Glu Lys Lys Trp Thr Ser Val Ile Arg Leu Gln Lys Lys Val 
     50                  55                  60
Met Glu Leu Glu Ser Lys Leu Asn Glu Ala Lys Glu Glu Phe Thr Ser 
 65                  70                  75                  80
Gly Gly Pro Leu Gly Gln Lys Arg Asp Pro Lys Glu Trp Ile Pro Arg 
                 85                  90                  95
Pro Pro Glu Lys Tyr Ala Leu Ser Gly His Arg Ser Pro Val Thr Arg 
             100                105                110
Val Ile Phe His Pro Val Phe Ser Val Met Val Ser Ala Ser Glu Asp 
         115                120                125
Ala Thr Ile Lys Val Trp Asp Tyr Glu Thr Gly Asp Phe Glu Arg Thr 
     130                135                140
Leu Lys Gly His Thr Asp Ser Val Gln Asp Ile Ser Phe Asp His Ser 
 145                150                155                160
Gly Lys Leu Leu Ala Ser Cys Ser Ala Asp Met Thr Ile Lys Leu Trp 
                 165                170                175
Asp Phe Gln Gly Phe Glu Cys Ile Arg Thr Met His Gly His Asp His 
             180                185                190
Asn Val Ser Ser Val Ala Ile Met Pro Asn Gly Asp His Ile Val Ser 
         195                200                205
Ala Ser Arg Asp Lys Thr Ile Lys Met Trp Glu Val Gln Thr Gly Tyr 
     210                215                220
Cys Val Lys Thr Phe Thr Gly His Arg Glu Trp Val Arg Met Val Arg 
 225                230                235                240
Pro Asn Gln Asp Gly Thr Leu Ile Ala Ser Cys Ser Asn Asp Gln Thr 
                 245                250                255
Val Arg Val Trp Val Val Ala Thr Lys Glu Cys Lys Ala Glu Leu Arg 
             260                265                270
Glu His Glu His Val Val Glu Cys Ile Ser Trp Ala Pro Glu Ser Ser 
         275                280                285
Tyr Ser Ser Ile Ser Glu Ala Thr Gly Ser Glu Thr Lys Lys Ser Gly 
     290                295                300
Lys Pro Gly Pro Phe Leu Leu Ser Gly Ser Arg Asp Lys Thr Ile Lys 
 305                310                315                320
Met Trp Asp Val Ser Thr Gly Met Cys Leu Met Thr Leu Val Gly His 
                 325                330                335
Asp Asn Trp Val Arg Gly Val Leu Phe His Ser Gly Gly Lys Phe Ile 
             340                345                350
Leu Ser Cys Ala Asp Asp Lys Thr Leu Arg Val Trp Asp Tyr Lys Asn 
         355                360                365
Lys Arg Cys Met Lys Thr Leu Asn Ala His Glu His Phe Val Thr Ser 
     370                375                380
Leu Asp Phe His Lys Thr Ala Pro Tyr Val Val Thr Gly Ser Val Asp 
 385                390                395                400
Gln Thr Val Lys Val Trp Glu Cys Arg 
                 405



<210> 4364
<211> 359
<212> DNA
<213> Homo sapiens
<308> L13388
<400> 4364

cgttaatca  actatagag  cataagtgg  atcagtttt  atttttcta  ttgtttaaa  60
tgtgtttta  accagtgtt  gcaagtaat  gggtgttag  ttgagatgg  taaaggtgg  120
ttggggagg  acttcgttg  aatggtttt  ctgtaaaaa  tgtttccaa  tccgctgaa  180
tgttgctga  aagcatggt  ctggtaaca  ttcaacaat  cgtggctgc  cattcttgc  240
tactttact  tcccactga  gcaggttag  gttgaaggt  gtatggaaa  gcctgcatg  300
ctgttccat  ctgggggga  gtttatttt  agttgtgct  atgacaaga  cccacgggt  359



<210> 4365
<211> 687
<212> DNA
<213> Rattus norvegicus
<308> AA799601
<400> 4365

aaaagcatg  ttatgtgac  gcacataaa  gtctgtgta  aaagggcat  atgacagtt  60
ataccacaa  gattacagt  agaaaagca  tttatgaca  tatttcaca  attcacaag  120
atcacttta  tatacaaag  aactgctac  attctgaac  caaagcagc  agtatgtac  180
tagtgttaa  aaaatgcat  gtgtcttgg  acttttatt  tttacacat  aagcacaaa  240
agatttagg  aaaaaattt  aacagggac  tttctagat  gtgggaacg  tattagaaa  300
gtatgtccc  tctcatagt  attagtatt  ttctccaat  ggaacatca  agttaaagc  360
cataccctg  tttgtgcta  cagttccgg  gaggtattt  ctactccag  actcaagga  420
aacccaaaa  gccaaacac  attctagga  ttccctggt  attttgttt  tcaaaagtt  480
caagtgaca  gtctaggtt  gaaatgatc  cttccactg  ggcattata  ccgatgtgt  540
cagatcagt  gaagacagc  ttacacaga  aactgctaa  tagcacact  cttcaccat  600
ctaataaat  tacacacac  gaaaaatgt  gacaaaatt  cccacnttn  atataaata  660
ttttattac  tacacattg  agtggca  687



<210> 4366
<211> 193
<212> DNA
<213> Homo sapiens
<308> AA731950
<400> 4366

ttttttttt  ttttttttt  ttttttttt  tgagttttt  aaagcatgt  tatgtgact  60
cacataaat  tttgtgtaa  aagagcatt  tgacagttg  taccacaaa  attacagta  120
gaaaaagca  tttatgaca  tatttcaca  attcacaag  atcacttta  tatacaaag  180
aaactgcta  tat  193



<210> 4367
<211> 663
<212> DNA
<213> Rattus norvegicus
<308> AA799609
<400> 4367

aagaaagta  ttcagaaag  ggaaaataa  ctagatcat  tatatatat  ttttttaat  60
aaaaccttt  cataatctt  atgcataaa  acccagggg  ggccatatt  tctgtgaca  120
ccccaaata  ccgctcttt  aggctagtg  ctgggactt  ccatagcca  cagcaatgt  180
gtgaaggcc  tccctatct  cccctgggc  cagccagac  tgtcgcagt  acagcttta  240
cttctgaga  atgttcttg  ctagatggg  gggcaggga  gaacaccct  gacattctt  300
atctaaact  ctctggcaa  tcgaggaaa  tgactgatg  tcaagggtc  gagcagttc  360
ggggcttct  aagagttgt  ctctgtagc  tggggccac  gcacatgat  gcatggtgt  420
caaaggata  acaaggcat  agtaaaagc  ttgaagatc  ccgcctcca  ggtagacag  480
ccttctttc  taaatatgt  aaagaacaa  gtccaactc  cttgattcc  aaacacact  540
ttaactgag  aatctactt  agagacaaa  ctatagtaa  ggaaggtca  tcagtcata  600
atctggggt  agagtcaga  ctctgggtg  ggaaaagaa  tccctgggt  ttgggaggt  660
ctg  663



<210> 4368
<211> 663
<212> DNA
<213> Rattus norvegicus
<308> AA799609
<400> 4368

aagaaagta  ttcagaaag  ggaaaataa  ctagatcat  tatatatat  ttttttaat  60
aaaaccttt  cataatctt  atgcataaa  acccagggg  ggccatatt  tctgtgaca  120
ccccaaata  ccgctcttt  aggctagtg  ctgggactt  ccatagcca  cagcaatgt  180
gtgaaggcc  tccctatct  cccctgggc  cagccagac  tgtcgcagt  acagcttta  240
cttctgaga  atgttcttg  ctagatggg  gggcaggga  gaacaccct  gacattctt  300
atctaaact  ctctggcaa  tcgaggaaa  tgactgatg  tcaagggtc  gagcagttc  360
ggggcttct  aagagttgt  ctctgtagc  tggggccac  gcacatgat  gcatggtgt  420
caaaggata  acaaggcat  agtaaaagc  ttgaagatc  ccgcctcca  ggtagacag  480
ccttctttc  taaatatgt  aaagaacaa  gtccaactc  cttgattcc  aaacacact  540
ttaactgag  aatctactt  agagacaaa  ctatagtaa  ggaaggtca  tcagtcata  600
atctggggt  agagtcaga  ctctgggtg  ggaaaagaa  tccctgggt  ttgggaggt  660
ctg  663



<210> 4369
<211> 708
<212> DNA
<213> Rattus norvegicus
<308> AA799612
<400> 4369

caagaggtt  aacagaatt  acttgtata  tttccattt  ctatactac  tgaaggcat  60
ggatagctt  atcttagct  tctacaata  tgtgtttta  gtctaccca  taaactaag  120
ggcagtaca  cttgaatac  actgaggag  tgagaagca  ctcggcagg  cctggtgct  180
aacagttcc  gaataaaca  gtagcgcgc  gccgcatta  aaggtagtt  gcaaatatt  240
aagttacac  gagattcct  ccaaacctc  gccttgctc  aaccagcgc  cctggccac  300
gctaacacc  cggcacggc  tttggtgaa  ggtgatggt  ttactttct  cttaatcaa  360
agcctgtgg  ggtgctgcc  cgcagcaga  taagtcagc  ctgctcgag  acgaggtgc  420
aattgtgaa  tcacaaaag  tacagttta  atgagaaac  cacattaac  agtggccca  480
atacagagc  ggacagaac  agaccagta  gtctatagt  actcaactg  actaacata  540
gtacattca  aataaagcc  gagatcaga  taggtttta  aatcaaatt  gcagacttt  600
ttgataaaa  agaagagtg  ccttctgca  ttggaaatg  ggctctcac  tggcgaana  660
canagactt  gcagtccct  ctgcacagg  aaggaaata  gtgacaaa  708



<210> 4370
<211> 152
<212> PRT
<213> Rattus norvegicus
<308> P23567
<400> 4370

Met Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu 
  1               5                  10                  15
Gln Glu Asp Pro Pro Val Gly Val Ser Gly Ala Pro Ser Glu Asn Asn 
             20                  25                  30
Ile Met Gln Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe 
         35                  40                  45
Glu Asp Gly Thr Phe Lys Leu Val Ile Glu Phe Ser Glu Glu Tyr Pro 
     50                  55                  60
Asn Lys Pro Pro Thr Val Arg Phe Leu Ser Lys Met Phe His Pro Asn 
 65                  70                  75                  80
Val Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp 
                 85                  90                  95
Ser Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu 
             100                105                110
Leu Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln 
         115                120                125
Leu Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile 
     130                135                140
Val Glu Gln Ser Trp Asn Asp Ser 
 145                150



<210> 4371
<211> 1355
<212> DNA
<213> Homo sapiens
<308> BC005979
<400> 4371

agactgacc  cggggcagc  gcggagcat  tcgaccccg  cccggagga  gctcatgcg  60
gatttcaag  ggttacaag  ggacccacc  gtgggtgtc  gtggcgcac  atctgaaaa  120
aacatcatg  agtggaatg  agttatatt  ggaccagaa  ggacacctt  tgaagatgg  180
acttttaaa  tagtaatag  attttctga  gaatatcca  ataaaccac  aactgttag  240
tttttatcc  aaatgtttc  tccaaatgt  tatgctgat  gtagcatat  tttagatat  300
cttcagaat  gatggagtc  aacatatga  gtatcttct  tcttaacat  aattcagtc  360
ctgctggat  aaccgaatc  taacagtcc  gccaatagc  aggcagcac  gctttatca  420
gaaaacaaa  gagaatatg  gaaaagagt  tcggccatt  ttgaacaaa  ctggaatga  480
tcataatag  caactggtc  gttaatctt  ttcatcatt  ttgtgtata  tttacctct  540
attagaaag  ctaacaaat  ttaagtgcc  caggtttta  ggattctgc  gaaaaaaaa  600
aaaaattcc  tcagtttag  acctacaaa  gcttgtgta  cttgattaa  gtacttttt  660
ttgcatggt  tgaactaag  tattgctgc  taaatttgt  atatatcct  tttgtattt  720
tttccaagt  tataatgtt  gtgtggagt  ttcatgaca  aatatacac  ttttgtaaa  780
ctgtacttt  ttcaaatat  gaatgcctt  tttttgaat  ctttagatt  ttaaattgg  840
gaaaagcac  taaagtttt  tatatatga  tattacatg  aaagctgtt  aaatacata  900
cttcagtgc  agagacttt  tcacttatt  ccttatgtg  gtaggaggg  ttaataagt  960
tctagctct  catctattg  tagtttcat  tacaatttc  aaagaacat  cttatattt  1020
atcaaggaa  tcttcaaat  tgattctaa  tagcgatta  aatctccaa  tttattttg  1080
atgtacctc  attagtttc  attgagtaa  tctagacat  actggtttg  ctctgtcca  1140
ctctgtatt  aggccattt  ttacagttt  ttcatgcat  acttactgt  aaaactgta  1200
cttttgcga  ttcacagtt  gcacttctg  catgagcag  gaactgatg  gacttgttt  1260
gctgcttgg  agcacttta  aaaattttt  gattaatga  gaaagtaaa  ccataaaca  1320
ttgccgaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  1355



<210> 4372
<211> 152
<212> PRT
<213> Homo sapiens
<308> P23567
<400> 4372

Met Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu 
  1               5                  10                  15
Gln Glu Asp Pro Pro Val Gly Val Ser Gly Ala Pro Ser Glu Asn Asn 
             20                  25                  30
Ile Met Gln Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe 
         35                  40                  45
Glu Asp Gly Thr Phe Lys Leu Val Ile Glu Phe Ser Glu Glu Tyr Pro 
     50                  55                  60
Asn Lys Pro Pro Thr Val Arg Phe Leu Ser Lys Met Phe His Pro Asn 
 65                  70                  75                  80
Val Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp 
                 85                  90                  95
Ser Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu 
             100                105                110
Leu Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln 
         115                120                125
Leu Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile 
     130                135                140
Val Glu Gln Ser Trp Asn Asp Ser 
 145                150



<210> 4373
<211> 539
<212> DNA
<213> Rattus norvegicus
<308> AA799633
<400> 4373

gactgcaaa  aaagacatc  gctttattt  ttttccatc  gtagcacat  ctgtttctt  60
agcatggca  ccccatgct  agaggcata  gggtgctca  tcagagact  cagggcatg  120
ggaccatgg  ctgtggtct  atgatcggt  ccttcttca  ggctccagg  aggatgctg  180
tcctcagcc  ttgcgggcg  tgctcacac  gtgctggta  gccttggcc  ggtcggagc  240
tagaagtac  tcatgcaga  ggtcacggt  gcagcggag  atctgggcc  gtaggccag  300
gcatacagg  tccactctg  ggggcttta  tgtgctctc  gcttttgaa  ccgcctcgt  360
gaattgttg  gaagacagt  tatacagct  agcattctt  tcttggatg  gttcctgct  420
ctccttgta  taagtgtca  ggcggctga  ctcggcctc  ctgttcttc  gttccctgg  480
ctgtcaagt  gagcaaaga  acaacttgg  tccccagag  ttgaagaat  caaaaatcc  539



<210> 4374
<211> 273
<212> PRT
<213> Rattus norvegicus
<308> BAB29792
<400> 4374

Met Gly Ser Ala Glu Ser Ala Glu Ala Arg Arg Trp Ser Leu Glu Met 
  1               5                  10                  15
Asp Glu Glu Glu Arg Val Arg Val Leu Gln Gly Ile Arg Leu Ser Glu 
             20                  25                  30
Ser Val Val Asn Arg Met Lys Asp Cys Ser Gln Pro Ser Ala Gly Glu 
         35                  40                  45
Gln Leu Val Pro Gly Phe Gly Pro Ser Ser Ser Ala Pro Val Pro Thr 
     50                  55                  60
Val Pro Leu Pro Ala Ile Ser Val Pro Thr Val Pro Ala Pro Thr Thr 
 65                  70                  75                  80
Pro Val Pro Thr Ala Pro Ser Ser Ser Val Arg Gly Leu Pro Gly Gly 
                 85                  90                  95
Thr Cys Lys Gly Pro Leu Thr Asp Val Lys Val Pro Ser Ala Glu Ser 
             100                105                110
Gly Gly Gly Leu Gln Ser Ser Ala Val Lys Glu Asp Leu Lys Lys Phe 
         115                120                125
Gln Gln Glu Gln Leu Ala Val Gln Asp Glu Met Val Arg Val Ala Lys 
     130                135                140
Lys Glu Lys Glu Ala Ala Glu Lys His Leu Lys Ala Ser Leu Pro Lys 
 145                150                155                160
Lys Lys Ala Ser Leu Thr His Glu Gln Gln Gln Ser Ala Arg Leu Ala 
                 165                170                175
Arg Glu Leu Glu Asp Arg Glu Ala Glu Leu Ser Arg Arg Asp Thr Phe 
             180                185                190
Tyr Lys Glu Gln Gln Gly Arg Ile Gln Glu Lys Asn Ala Glu Leu Tyr 
         195                200                205
Lys Leu Ser Ser Gln Gln Phe His Glu Ala Ala Ser Lys Ala Glu Ser 
     210                215                220
Thr Ile Lys Pro Arg Arg Val Glu Pro Val Cys Ser Gly Leu Gln Ala 
 225                230                235                240
Gln Ile Leu Arg Cys Tyr Arg Asp His Leu His Glu Val Leu Leu Cys 
                 245                250                255
Ser Asp Leu Val Lys Ala Tyr Gln His Cys Val Ser Thr Ala Arg Lys 
             260                265                270
Gly 
         275



<210> 4375
<211> 984
<212> DNA
<213> Homo sapiens
<308> BC006123
<400> 4375

ctcgggtct  gtggctgcc  gccctgcgg  atctcgcca  ggggagcac  gagagcagc  60
agggccgca  ggtgtcctt  ggagtggac  aggaggagc  ggtccgggt  ctgcagggt  120
tccggctgt  tgaaaacgt  gtgaaccgc  tgaaggagc  cagctctcc  ccccctgct  180
ccacatctt  tacctttgg  cttcaagat  gcaacttga  agcccctca  aaagaatcc  240
cactgccca  gtcggggag  agtggtggc  agcagccct  agggatgaa  gagggtgtc  300
agaggtatg  acaggagca  gctgctatc  aggataagc  cttccaggt  gcaaagagg  360
aaagagagg  tgccaccaa  cactccaag  catccctgc  cacgggcga  ggcagcatc  420
gccatgagg  gcagaagtc  gtccggctg  ccagggagc  ggagagcag  gaggcagag  480
taagacgcc  tgacacctt  tacaaggag  agctggagc  tattgagag  aagaatgct  540
agatgtata  actgtcttc  gagcaattc  atgaggcag  ctcaaagat  gagagcaca  600
taaagcccc  cagggtgga  cccgtctgc  cagggttgc  ggcccagat  ctccactgc  660
accgagatc  cccgcatga  gtgctgctg  gctcggacc  ggtcaaggc  taccagcgc  720
gcgtgagcg  cgcccacaa  ggctgagga  cagacatca  tccctgccc  ggcagtgac  780
tggagccct  aagaaggga  caatcatgg  accacagcc  ctgtgccct  ccgtttcct  840
ctgggcccc  gcatatgcc  ctgagcctg  ggctgccac  tgtttagga  acaaagtat  900
cgctactgt  tgaaaacaa  taaagcaga  gcctttgtt  tcagtcaaa  aaaaaaaaa  960
aaaaaaaaa  aaaaaaaaa  aaaa  984



<210> 4376
<211> 236
<212> PRT
<213> Homo sapiens
<308> BC006123
<400> 4376

Met Gly Ser Thr Glu Ser Ser Glu Gly Arg Arg Val Ser Phe Gly Val 
  1               5                  10                  15
Asp Glu Glu Glu Arg Val Arg Val Leu Gln Gly Val Arg Leu Ser Glu 
             20                  25                  30
Asn Val Val Asn Arg Met Lys Glu Pro Ser Ser Pro Pro Pro Ala Pro 
         35                  40                  45
Thr Ser Ser Thr Phe Gly Leu Gln Asp Gly Asn Leu Arg Ala Pro His 
     50                  55                  60
Lys Glu Ser Thr Leu Pro Arg Ser Gly Ser Ser Gly Gly Gln Gln Pro 
 65                  70                  75                  80
Ser Gly Met Lys Glu Gly Val Lys Arg Tyr Glu Gln Glu His Ala Ala 
                 85                  90                  95
Ile Gln Asp Lys Leu Phe Gln Val Ala Lys Arg Glu Arg Glu Ala Ala 
             100                105                110
Thr Lys His Ser Lys Ala Ser Leu Pro Thr Gly Glu Gly Ser Ile Ser 
         115                120                125
His Glu Glu Gln Lys Ser Val Arg Leu Ala Arg Glu Leu Glu Ser Arg 
     130                135                140
Glu Ala Glu Leu Arg Arg Arg Asp Thr Phe Tyr Lys Glu Gln Leu Glu 
 145                150                155                160
Arg Ile Glu Arg Lys Asn Ala Glu Met Tyr Lys Leu Ser Ser Glu Gln 
                 165                170                175
Phe His Glu Ala Ala Ser Lys Met Glu Ser Thr Ile Lys Pro Arg Arg 
             180                185                190
Val Glu Pro Val Cys Ser Gly Leu Gln Ala Gln Ile Leu His Cys Tyr 
         195                200                205
Arg Asp Arg Pro His Glu Val Leu Leu Cys Ser Asp Leu Val Lys Ala 
     210                215                220
Tyr Gln Arg Cys Val Ser Ala Ala His Lys Gly Ter 
 225                230                235



<210> 4377
<211> 571
<212> DNA
<213> Rattus norvegicus
<308> AA799637
<400> 4377

aagcaaaag  agatgaggg  ggatcaggt  aagtaatat  ggttaaaag  aagagaaaa  60
agacaccaa  agttatttc  ttcctaagg  ctcagatag  ttcttaagt  ttttcttca  120
ctccaaagg  aatttctcg  agcacttct  acagactgg  ttcatgtca  actccacaa  180
tttattcca  agagaagca  tgagaatgg  gtggaaggg  tagaacggt  acagacaca  240
tggctttct  tttctctgc  tctctttat  ccttgcttc  ctctcccgt  tggcaagtc  300
cctcttaag  tcttctggc  ttttctcat  acagtattt  cagactggc  ttagatcaa  360
tgcaacaaa  ttatccttg  gtgttagtt  ggtattgca  gtggaacag  caaagcagc  420
cacacacca  gccttgttg  gggcagaga  cacgtcacc  tctatgaca  ggttgcaat  480
gaaacaaac  tcaccaaat  gctgattat  gtgagtctc  caataggcc  agcccttcc  540
ctcataatg  cgatgtcca  gaaatgggt  t  571



<210> 4378
<211> 457
<212> PRT
<213> Rattus norvegicus
<308> AAD13197
<400> 4378

Met Asp Ser Phe Lys Val Val Leu Glu Gly Pro Ala Pro Trp Gly Phe 
  1               5                  10                  15
Arg Leu Gln Gly Gly Lys Asp Phe Asn Val Pro Leu Ser Ile Ser Arg 
             20                  25                  30
Leu Thr Pro Gly Gly Lys Ala Ala Gln Ala Gly Val Ala Val Gly Asp 
         35                  40                  45
Trp Val Leu Ser Ile Asp Gly Glu Asn Ala Gly Ser Leu Thr His Ile 
     50                  55                  60
Glu Ala Gln Asn Lys Ile Arg Ala Cys Gly Glu Arg Leu Ser Leu Gly 
 65                  70                  75                  80
Leu Ser Arg Ala Gln Pro Ala Gln Ser Lys Pro Gln Lys Ala Leu Thr 
                 85                  90                  95
Pro Pro Ala Asp Pro Pro Arg Tyr Thr Phe Ala Pro Ser Ala Ser Leu 
             100                105                110
Asn Lys Thr Ala Arg Pro Phe Gly Ala Pro Pro Pro Thr Asp Ser Ala 
         115                120                125
Leu Ser Gln Asn Gly Gln Leu Leu Arg Gln Leu Val Pro Asp Ala Ser 
     130                135                140
Lys Gln Arg Leu Met Glu Asn Thr Glu Asp Trp Arg Pro Arg Pro Gly 
 145                150                155                160
Thr Gly Gln Ser Arg Ser Phe Arg Ile Leu Ala His Leu Thr Gly Thr 
                 165                170                175
Glu Phe Met Gln Asp Pro Asp Glu Glu Phe Met Lys Lys Ser Ser Gln 
             180                185                190
Val Pro Arg Thr Glu Ala Pro Ala Pro Ala Ser Thr Ile Pro Gln Glu 
         195                200                205
Ser Trp Pro Gly Pro Thr Thr Pro Ser Pro Thr Ser Arg Pro Pro Trp 
     210                215                220
Ala Val Asp Pro Ala Phe Ala Glu Arg Tyr Ala Pro Asp Lys Thr Ser 
 225                230                235                240
Thr Val Leu Thr Arg His Ser Gln Pro Ala Thr Pro Thr Pro Leu Gln 
                 245                250                255
Asn Arg Thr Ser Ile Val Gln Ala Ala Ala Gly Gly Gly Thr Gly Gly 
             260                265                270
Gly Ser Asn Asn Gly Lys Thr Pro Val Cys His Gln Cys His Lys Ile 
         275                280                285
Ile Arg Gly Arg Tyr Leu Val Ala Leu Gly His Ala Tyr His Pro Glu 
     290                295                300
Glu Phe Val Cys Ser Gln Cys Gly Lys Val Leu Glu Glu Gly Gly Phe 
 305                310                315                320
Phe Glu Glu Lys Gly Ala Ile Phe Cys Pro Ser Cys Tyr Asp Val Arg 
                 325                330                335
Tyr Ala Pro Ser Cys Ala Lys Cys Lys Lys Lys Ile Thr Gly Glu Ile 
             340                345                350
Met His Ala Leu Lys Met Thr Trp His Val Pro Cys Phe Thr Cys Ala 
         355                360                365
Ala Cys Lys Thr Pro Ile Arg Asn Arg Ala Phe Tyr Met Glu Glu Gly 
     370                375                380
Ala Pro Tyr Cys Glu Arg Asp Tyr Glu Lys Met Phe Gly Thr Lys Cys 
 385                390                395                400
Arg Gly Cys Asp Phe Lys Ile Asp Ala Gly Asp Arg Phe Leu Glu Ala 
                 405                410                415
Leu Gly Phe Ser Trp His Asp Thr Cys Phe Val Cys Ala Ile Cys Gln 
             420                425                430
Ile Asn Leu Glu Gly Lys Thr Phe Tyr Ser Lys Lys Asp Lys Pro Leu 
         435                440                445
Cys Lys Ser His Ala Phe Ser His Val 
     450                455



<210> 4379
<211> 1236
<212> DNA
<213> Homo sapiens
<308> U09284
<400> 4379

tagttcaag  caacagaga  aaagctaag  tgaggaagt  ctgtacagt  taggaaata  60
aggctttca  agataattc  cagtgatgt  aaactggcc  cccaagccc  gataacaac  120
tggccaacg  cctggccag  gccacttgc  agcgctgca  gggcggctt  gcgcccgct  180
agaagatcg  gaacagtaa  ggggagctg  accatgagc  gtgtttcgt  tgcgctcag  240
gcttccagc  gttcccaga  ggactcttc  atgagtttg  aggaagaaa  tactgtgaa  300
atgactttc  gatgctctt  gccccttgc  gtcatcagt  tggtgaatt  atcattggc  360
gagttatca  agccatgaa  aacagctgg  atccggagt  cttccgctg  gacctctgc  420
aggaagttc  ggcagatat  gggtttgtc  agaatgctg  gagacacct  tgtcgcccc  480
gtcataatc  tgagaaagc  agaggcctt  ggaaataca  ctgccagaa  tgccatgct  540
tcatcgatg  gcagcctct  atattcaag  acgacccct  ccatccaga  catttcaac  600
gcgccaact  cgggaagga  ctgactgcc  atgcacggg  gctgaaagg  gagctatac  660
gcctcccat  ccatgataa  atgggggtc  ccatctgtg  tgcttgccg  cggcccatc  720
aagggcgcg  ggtgaacgc  atgggcaag  agtggcatg  ggagcattt  gtttgtgcc  780
agtgtgaga  accctttct  ggacatcgc  attatgaga  gaaaggcct  gcatattgt  840
aaactcact  taaccagct  tttggtgat  tttgcttcc  ctgcaatcg  gttatagaa  900
gtgatgtgg  ctctgctct  aataaggcc  ggtgcgtga  ctgctttgc  tgttctacc  960
gcaacacta  attaacact  aagaataag  ttgtggagt  tgacatgaa  ccagtctgt  1020
agaagtgct  tgagaaatt  ccattggag  tgaagaaaa  acttaagaa  ctagctgag  1080
ccttaggaa  gaaataagt  cctttattt  ttcttttct  tgcaagata  gagattacc  1140
acattactt  tcttgatct  cccatattt  aagctatat  tcaaagcag  tgagagaag  1200
ggacctata  gaatggttt  atgtcattt  tttaaa  1236



<210> 4380
<211> 325
<212> PRT
<213> Homo sapiens
<308> P48059
<400> 4380

Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly 
  1               5                  10                  15
Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
             20                  25                  30
Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly 
         35                  40                  45
Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln 
     50                  55                  60
Met Leu Phe Ala Pro Cys Cys His Gln Cys Gly Glu Phe Ile Ile Gly 
 65                  70                  75                  80
Arg Val Ile Lys Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg 
                 85                  90                  95
Cys Asp Leu Cys Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn 
             100                105                110
Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg 
         115                120                125
Gly Leu Gly Lys Tyr Ile Cys Gln Lys Cys His Ala Ile Ile Asp Glu 
     130                135                140
Gln Pro Leu Ile Phe Lys Asn Asp Pro Tyr His Pro Asp His Phe Asn 
 145                150                155                160
Cys Ala Asn Cys Gly Lys Glu Leu Thr Ala Asp Ala Arg Glu Leu Lys 
                 165                170                175
Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile 
             180                185                190
Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Met 
         195                200                205
Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys 
     210                215                220
Pro Phe Leu Gly His Arg His Tyr Glu Arg Lys Gly Leu Ala Tyr Cys 
 225                230                235                240
Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys Phe His Cys Asn 
                 245                250                255
Arg Val Ile Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys 
             260                265                270
Val Asn Cys Phe Ala Cys Ser Thr Cys Asn Thr Lys Leu Thr Leu Lys 
         275                280                285
Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Lys Cys Tyr 
     290                295                300
Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ala Glu 
 305                310                315                320
Thr Leu Gly Arg Lys 
                 325



<210> 4381
<211> 571
<212> DNA
<213> Rattus norvegicus
<308> AA799637
<400> 4381

aagcaaaag  agatgaggg  ggatcaggt  aagtaatat  ggttaaaag  aagagaaaa  60
agacaccaa  agttatttc  ttcctaagg  ctcagatag  ttcttaagt  ttttcttca  120
ctccaaagg  aatttctcg  agcacttct  acagactgg  ttcatgtca  actccacaa  180
tttattcca  agagaagca  tgagaatgg  gtggaaggg  tagaacggt  acagacaca  240
tggctttct  tttctctgc  tctctttat  ccttgcttc  ctctcccgt  tggcaagtc  300
cctcttaag  tcttctggc  ttttctcat  acagtattt  cagactggc  ttagatcaa  360
tgcaacaaa  ttatccttg  gtgttagtt  ggtattgca  gtggaacag  caaagcagc  420
cacacacca  gccttgttg  gggcagaga  cacgtcacc  tctatgaca  ggttgcaat  480
gaaacaaac  tcaccaaat  gctgattat  gtgagtctc  caataggcc  agcccttcc  540
ctcataatg  cgatgtcca  gaaatgggt  t  571



<210> 4382
<211> 457
<212> PRT
<213> Rattus norvegicus
<308> AAD13197
<400> 4382

Met Asp Ser Phe Lys Val Val Leu Glu Gly Pro Ala Pro Trp Gly Phe 
  1               5                  10                  15
Arg Leu Gln Gly Gly Lys Asp Phe Asn Val Pro Leu Ser Ile Ser Arg 
             20                  25                  30
Leu Thr Pro Gly Gly Lys Ala Ala Gln Ala Gly Val Ala Val Gly Asp 
         35                  40                  45
Trp Val Leu Ser Ile Asp Gly Glu Asn Ala Gly Ser Leu Thr His Ile 
     50                  55                  60
Glu Ala Gln Asn Lys Ile Arg Ala Cys Gly Glu Arg Leu Ser Leu Gly 
 65                  70                  75                  80
Leu Ser Arg Ala Gln Pro Ala Gln Ser Lys Pro Gln Lys Ala Leu Thr 
                 85                  90                  95
Pro Pro Ala Asp Pro Pro Arg Tyr Thr Phe Ala Pro Ser Ala Ser Leu 
             100                105                110
Asn Lys Thr Ala Arg Pro Phe Gly Ala Pro Pro Pro Thr Asp Ser Ala 
         115                120                125
Leu Ser Gln Asn Gly Gln Leu Leu Arg Gln Leu Val Pro Asp Ala Ser 
     130                135                140
Lys Gln Arg Leu Met Glu Asn Thr Glu Asp Trp Arg Pro Arg Pro Gly 
 145                150                155                160
Thr Gly Gln Ser Arg Ser Phe Arg Ile Leu Ala His Leu Thr Gly Thr 
                 165                170                175
Glu Phe Met Gln Asp Pro Asp Glu Glu Phe Met Lys Lys Ser Ser Gln 
             180                185                190
Val Pro Arg Thr Glu Ala Pro Ala Pro Ala Ser Thr Ile Pro Gln Glu 
         195                200                205
Ser Trp Pro Gly Pro Thr Thr Pro Ser Pro Thr Ser Arg Pro Pro Trp 
     210                215                220
Ala Val Asp Pro Ala Phe Ala Glu Arg Tyr Ala Pro Asp Lys Thr Ser 
 225                230                235                240
Thr Val Leu Thr Arg His Ser Gln Pro Ala Thr Pro Thr Pro Leu Gln 
                 245                250                255
Asn Arg Thr Ser Ile Val Gln Ala Ala Ala Gly Gly Gly Thr Gly Gly 
             260                265                270
Gly Ser Asn Asn Gly Lys Thr Pro Val Cys His Gln Cys His Lys Ile 
         275                280                285
Ile Arg Gly Arg Tyr Leu Val Ala Leu Gly His Ala Tyr His Pro Glu 
     290                295                300
Glu Phe Val Cys Ser Gln Cys Gly Lys Val Leu Glu Glu Gly Gly Phe 
 305                310                315                320
Phe Glu Glu Lys Gly Ala Ile Phe Cys Pro Ser Cys Tyr Asp Val Arg 
                 325                330                335
Tyr Ala Pro Ser Cys Ala Lys Cys Lys Lys Lys Ile Thr Gly Glu Ile 
             340                345                350
Met His Ala Leu Lys Met Thr Trp His Val Pro Cys Phe Thr Cys Ala 
         355                360                365
Ala Cys Lys Thr Pro Ile Arg Asn Arg Ala Phe Tyr Met Glu Glu Gly 
     370                375                380
Ala Pro Tyr Cys Glu Arg Asp Tyr Glu Lys Met Phe Gly Thr Lys Cys 
 385                390                395                400
Arg Gly Cys Asp Phe Lys Ile Asp Ala Gly Asp Arg Phe Leu Glu Ala 
                 405                410                415
Leu Gly Phe Ser Trp His Asp Thr Cys Phe Val Cys Ala Ile Cys Gln 
             420                425                430
Ile Asn Leu Glu Gly Lys Thr Phe Tyr Ser Lys Lys Asp Lys Pro Leu 
         435                440                445
Cys Lys Ser His Ala Phe Ser His Val 
     450                455



<210> 4383
<211> 1236
<212> DNA
<213> Homo sapiens
<308> U09284
<400> 4383

tagttcaag  caacagaga  aaagctaag  tgaggaagt  ctgtacagt  taggaaata  60
aggctttca  agataattc  cagtgatgt  aaactggcc  cccaagccc  gataacaac  120
tggccaacg  cctggccag  gccacttgc  agcgctgca  gggcggctt  gcgcccgct  180
agaagatcg  gaacagtaa  ggggagctg  accatgagc  gtgtttcgt  tgcgctcag  240
gcttccagc  gttcccaga  ggactcttc  atgagtttg  aggaagaaa  tactgtgaa  300
atgactttc  gatgctctt  gccccttgc  gtcatcagt  tggtgaatt  atcattggc  360
gagttatca  agccatgaa  aacagctgg  atccggagt  cttccgctg  gacctctgc  420
aggaagttc  ggcagatat  gggtttgtc  agaatgctg  gagacacct  tgtcgcccc  480
gtcataatc  tgagaaagc  agaggcctt  ggaaataca  ctgccagaa  tgccatgct  540
tcatcgatg  gcagcctct  atattcaag  acgacccct  ccatccaga  catttcaac  600
gcgccaact  cgggaagga  ctgactgcc  atgcacggg  gctgaaagg  gagctatac  660
gcctcccat  ccatgataa  atgggggtc  ccatctgtg  tgcttgccg  cggcccatc  720
aagggcgcg  ggtgaacgc  atgggcaag  agtggcatg  ggagcattt  gtttgtgcc  780
agtgtgaga  accctttct  ggacatcgc  attatgaga  gaaaggcct  gcatattgt  840
aaactcact  taaccagct  tttggtgat  tttgcttcc  ctgcaatcg  gttatagaa  900
gtgatgtgg  ctctgctct  aataaggcc  ggtgcgtga  ctgctttgc  tgttctacc  960
gcaacacta  attaacact  aagaataag  ttgtggagt  tgacatgaa  ccagtctgt  1020
agaagtgct  tgagaaatt  ccattggag  tgaagaaaa  acttaagaa  ctagctgag  1080
ccttaggaa  gaaataagt  cctttattt  ttcttttct  tgcaagata  gagattacc  1140
acattactt  tcttgatct  cccatattt  aagctatat  tcaaagcag  tgagagaag  1200
ggacctata  gaatggttt  atgtcattt  tttaaa  1236



<210> 4384
<211> 325
<212> PRT
<213> Homo sapiens
<308> P48059
<400> 4384

Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly 
  1               5                  10                  15
Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
             20                  25                  30
Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly 
         35                  40                  45
Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln 
     50                  55                  60
Met Leu Phe Ala Pro Cys Cys His Gln Cys Gly Glu Phe Ile Ile Gly 
 65                  70                  75                  80
Arg Val Ile Lys Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg 
                 85                  90                  95
Cys Asp Leu Cys Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn 
             100                105                110
Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg 
         115                120                125
Gly Leu Gly Lys Tyr Ile Cys Gln Lys Cys His Ala Ile Ile Asp Glu 
     130                135                140
Gln Pro Leu Ile Phe Lys Asn Asp Pro Tyr His Pro Asp His Phe Asn 
 145                150                155                160
Cys Ala Asn Cys Gly Lys Glu Leu Thr Ala Asp Ala Arg Glu Leu Lys 
                 165                170                175
Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile 
             180                185                190
Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Met 
         195                200                205
Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys 
     210                215                220
Pro Phe Leu Gly His Arg His Tyr Glu Arg Lys Gly Leu Ala Tyr Cys 
 225                230                235                240
Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys Phe His Cys Asn 
                 245                250                255
Arg Val Ile Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys 
             260                265                270
Val Asn Cys Phe Ala Cys Ser Thr Cys Asn Thr Lys Leu Thr Leu Lys 
         275                280                285
Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Lys Cys Tyr 
     290                295                300
Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ala Glu 
 305                310                315                320
Thr Leu Gly Arg Lys 
                 325



<210> 4385
<211> 665
<212> DNA
<213> Rattus norvegicus
<308> AA799641
<400> 4385

gaatcagat  aggcaaaga  tgggaactg  tttgaaatt  aggactttt  gaggtaacc  60
tggtcccct  ctgttaaaa  caggtattt  tctctcacg  ttttaagat  aagggccag  120
actatctgc  tcacaaatc  ttgttactc  gatttccac  tatgatcct  aaggttgga  180
agtggtccc  acagcccgt  aggcccagc  tcccgagcc  ccaactcta  ttagctgtc  240
atattacga  tatcagctt  attctctaa  atgtaataa  ctgacatgc  tttgacttc  300
acacactca  taacaagat  attacataa  actgcagtg  ttcccaagt  aagtgttct  360
tttaatcag  tctacaaag  atttactgg  atgacattt  tgacaaagc  acagacttc  420
atcaagcag  atcagtgta  tataaaaag  aagcaaagg  acaaaatag  cttcttctt  480
cagcctcat  agcagctgc  tttctgggg  aggacctac  cacatagta  ttccttgcc  540
agaaccagg  cctctgaag  agggaaatg  ggattaatg  attcctttt  ggtttttaa  600
gagactgta  tagaaatat  ttaaagata  ccttaaata  ccaacaatc  tctgactta  660
aactt  665



<210> 4386
<211> 472
<212> PRT
<213> Rattus norvegicus
<308> NP_036162
<400> 4386

Met Gly Ala Val Leu Ala Val Phe Ser Leu Ala Ser Trp Val Pro Cys 
  1               5                  10                  15
Leu Cys Ser Gly Ala Ser Cys Leu Leu Cys Ser Cys Cys Pro Ile Ser 
             20                  25                  30
Lys Asn Ser Thr Val Thr Arg Leu Ile Tyr Ala Phe Ile Leu Phe Leu 
         35                  40                  45
Gly Thr Ile Val Ser Cys Ile Met Met Thr Glu Gly Ile Gln Thr Gln 
     50                  55                  60
Leu Lys Lys Ile Pro Gly Phe Cys Glu Gly Gly Phe Gln Ile Lys Met 
 65                  70                  75                  80
Val Asp Thr Lys Ala Glu Lys Asp Cys Asp Val Leu Val Gly Phe Lys 
                 85                  90                  95
Ala Val Tyr Arg Ile Asn Phe Ala Val Ala Ile Phe Phe Phe Ala Phe 
             100                105                110
Phe Leu Leu Met Leu Lys Val Lys Thr Ser Lys Asp Pro Arg Ala Ala 
         115                120                125
Val His Asn Gly Phe Trp Phe Phe Lys Ile Ala Ala Ile Ile Gly Ile 
     130                135                140
Met Ile Gly Ser Phe Tyr Ile Pro Gly Gly Ser Phe Thr Glu Val Trp 
 145                150                155                160
Phe Val Ala Gly Met Leu Gly Ala Ser Phe Phe Ile Ile Ile Gln Leu 
                 165                170                175
Val Leu Leu Val Asp Met Ala His Ser Trp Asn Glu Leu Trp Val Asn 
             180                185                190
Arg Met Glu Glu Gly Asn Pro Arg Leu Trp Tyr Ala Ala Leu Leu Ser 
         195                200                205
Phe Thr Ser Leu Phe Tyr Ile Leu Ser Ile Val Phe Ala Ala Leu Leu 
     210                215                220
Tyr Val Phe Tyr Thr Lys Pro Asp Asp Cys Thr Glu Asn Lys Val Phe 
 225                230                235                240
Ile Ser Leu Asn Leu Ile Phe Cys Val Ala Val Ser Ile Val Ser Ile 
                 245                250                255
Leu Pro Lys Val Gln Glu His Gln Pro Arg Ser Gly Leu Leu Gln Ser 
             260                265                270
Ser Ile Ile Thr Leu Tyr Thr Leu Tyr Leu Thr Trp Ser Ala Met Thr 
         275                280                285
Asn Glu Pro Glu Arg Ser Cys Asn Pro Ser Leu Met Ser Ile Ile Thr 
     290                295                300
His Leu Thr Ser Pro Thr Val Ser Pro Ala Asn Ser Thr Thr Leu Ala 
 305                310                315                320
Pro Ala Tyr Arg Pro Pro Ser Gln Ser Gly His Phe Met Asn Leu Asp 
                 325                330                335
Asp Ile Trp Gly Leu Ile Ile Phe Val Phe Cys Leu Ile Tyr Ser Ser 
             340                345                350
Phe Arg Thr Ser Ser Asn Ser Gln Val Asn Lys Leu Thr Leu Ser Gly 
         355                360                365
Ser Asp Ser Val Ile Leu Gly Asp Thr Thr Asn Gly Ala Asn Asp Glu 
     370                375                380
Glu Asp Gly Gln Pro Arg Arg Ala Val Asp Asn Glu Lys Glu Gly Val 
 385                390                395                400
Gln Tyr Ser Tyr Ser Phe Phe His Leu Met Leu Cys Cys Ala Ser Leu 
                 405                410                415
Tyr Ile Met Met Thr Ile Thr Ser Trp Tyr Ser Pro Asp Ala Lys Phe 
             420                425                430
Gln Lys Val Ser Ser Lys Trp Leu Ala Val Trp Phe Lys Met Gly Ser 
         435                440                445
Ser Trp Leu Cys Leu Leu Leu Tyr Leu Trp Thr Leu Val Ala Pro Leu 
     450                455                460
Val Leu Thr Gly Arg Asp Phe Ser 
 465                470



<210> 4387
<211> 1892
<212> DNA
<213> Homo sapiens
<308> NM_006811
<400> 4387

ggcacgagc  cagctggca  ttaccaccg  gttagaaag  agcctcagg  ccggccacc  60
ccatcactg  cgtcaccat  ggggctgtg  tgggtgtct  ctccctcgc  agctgggtt  120
catgcctct  cagcggtgc  tcatgtttg  tgtgtagtt  ctgtcctaa  agtaagaat  180
ccacggtga  tcgcctcat  tatgctttc  ttctcctcc  gagcactgt  gtatcctat  240
tcatgcaga  aaaagagat  gaaacttac  tgaagaaga  tcctggatt  tgtgaaggg  300
gatttaaaa  ccatgaggc  gatataaat  cagataaag  ttgtgatgt  ctggttggt  360
ataaagctg  gtatcggat  agctttgcc  tggccatct  tttctttgt  ttttctctg  420
tcatgttca  agtaaaaac  agtaaagat  tccgagcgg  agtacacaa  gggttttgg  480
tcttcaaaa  tgctgccct  attggaatc  tggttggct  tttctacat  cctgggggc  540
atttcagct  agtctggtt  gttgttggc  tgatagggg  cgccctctt  atcctcatt  600
agctggtgc  gctggtaga  tttgctcat  cttggaatg  atcatgggt  aatcgaatg  660
aagaaggaa  cccaaggtt  tggtatgct  ctttactgt  tttcacaag  gccttttat  720
tcctgtcaa  catctgtgt  gggctgctc  atacatatt  caccaaacc  gatggctgc  780
cagaaaaca  gttcttcat  agtattaac  tgatccttt  cgttgtggc  tctattata  840
cgatccacc  aaaaattca  gaacaccag  ctcgctccg  cctcttgca  tcctccctc  900
tcaccctct  cactatgta  ctcacctgg  cagccatgt  caatgaacc  gatcgttcc  960
gcaatccca  cctgatgag  tttattaca  gcataactg  accaaccct  gctcctgga  1020
attcaactg  tgtggtccc  acccctact  caccatcaa  gagtgggtc  ttactggat  1080
cagataatt  tattggact  tttgtcttt  ttctctgcc  cttgtattc  agcatccgc  1140
cttccacta  tagccaagt  gacaagctg  ccctgtcag  gagtgacag  gtcatcctt  1200
gtgatacaa  taccagtgg  gccagtgat  aagaagatg  acagcctcg  cgggctgtg  1260
acaacgaga  agagggagt  cagtatagc  actccttat  ccacctcat  ctctgcttg  1320
cttccttgt  catcatgat  accctgacc  gctggtaca  ccctgatgc  aagtttcag  1380
gcatgacca  caagtggcc  gctgtgtgg  tcaagatca  ctccagctg  gtctgcctc  1440
tgctttacg  ctggaccct  gtggctcca  ttgtcctca  cagtcggga  ttcagctga  1500
cctctgagt  ccaaggaca  cactggaac  cacaaaggt  tccttcacc  aaaacccat  1560
tacctttta  gtttgtttc  actaaaata  taagtgaat  ctttgcaag  ttgactgta  1620
gcaggttta  atcagaagg  gagattgaa  aatgcttga  gcagaatcg  aacttctca  1680
ttatctgta  attatgttt  cttctaagg  tatagcaca  agggaacat  ttttgttta  1740
agtgaacta  agctgtgct  tgaagagag  tctttataa  gcctgtagg  tcttttaac  1800
ttggtttaa  atgtaagat  ggaaaatgt  ggatatttg  ggccatgct  aatatattt  1860
tattgcagt  tcctttaaa  gcaaaaaaa  aa  1892



<210> 4388
<211> 473
<212> PRT
<213> Homo sapiens
<308> NP_006802
<400> 4388

Met Gly Ala Val Leu Gly Val Phe Ser Leu Ala Ser Trp Val Pro Cys 
  1               5                  10                  15
Leu Cys Ser Gly Ala Ser Cys Leu Leu Cys Ser Cys Cys Pro Asn Ser 
             20                  25                  30
Lys Asn Ser Thr Val Thr Arg Leu Ile Tyr Ala Phe Ile Leu Leu Leu 
         35                  40                  45
Ser Thr Val Val Ser Tyr Ile Met Gln Arg Lys Glu Met Glu Thr Tyr 
     50                  55                  60
Leu Lys Lys Ile Pro Gly Phe Cys Glu Gly Gly Phe Lys Ile His Glu 
 65                  70                  75                  80
Ala Asp Ile Asn Ala Asp Lys Asp Cys Asp Val Leu Val Gly Tyr Lys 
                 85                  90                  95
Ala Val Tyr Arg Ile Ser Phe Ala Met Ala Ile Phe Phe Phe Val Phe 
             100                105                110
Ser Leu Leu Met Phe Lys Val Lys Thr Ser Lys Asp Leu Arg Ala Ala 
         115                120                125
Val His Asn Gly Phe Trp Phe Phe Lys Ile Ala Ala Leu Ile Gly Ile 
     130                135                140
Met Val Gly Ser Phe Tyr Ile Pro Gly Gly Tyr Phe Ser Ser Val Trp 
 145                150                155                160
Phe Val Val Gly Met Ile Gly Ala Ala Leu Phe Ile Leu Ile Gln Leu 
                 165                170                175
Val Leu Leu Val Asp Phe Ala His Ser Trp Asn Glu Ser Trp Val Asn 
             180                185                190
Arg Met Glu Glu Gly Asn Pro Arg Leu Trp Tyr Ala Ala Leu Leu Ser 
         195                200                205
Phe Thr Ser Ala Phe Tyr Ile Leu Ser Ile Ile Cys Val Gly Leu Leu 
     210                215                220
Tyr Thr Tyr Tyr Thr Lys Pro Asp Gly Cys Thr Glu Asn Lys Phe Phe 
 225                230                235                240
Ile Ser Ile Asn Leu Ile Leu Cys Val Val Ala Ser Ile Ile Ser Ile 
                 245                250                255
His Pro Lys Ile Gln Glu His Gln Pro Arg Ser Gly Leu Leu Gln Ser 
             260                265                270
Ser Leu Ile Thr Leu Tyr Thr Met Tyr Leu Thr Trp Ser Ala Met Ser 
         275                280                285
Asn Glu Pro Asp Arg Ser Cys Asn Pro Asn Leu Met Ser Phe Ile Thr 
     290                295                300
Arg Ile Thr Ala Pro Thr Leu Ala Pro Gly Asn Ser Thr Ala Val Val 
 305                310                315                320
Pro Thr Pro Thr Pro Pro Ser Lys Ser Gly Ser Leu Leu Asp Ser Asp 
                 325                330                335
Asn Phe Ile Gly Leu Phe Val Phe Val Leu Cys Leu Leu Tyr Ser Ser 
             340                345                350
Ile Arg Thr Ser Thr Asn Ser Gln Val Asp Lys Leu Thr Leu Ser Gly 
         355                360                365
Ser Asp Ser Val Ile Leu Gly Asp Thr Thr Thr Ser Gly Ala Ser Asp 
     370                375                380
Glu Glu Asp Gly Gln Pro Arg Arg Ala Val Asp Asn Glu Lys Glu Gly 
 385                390                395                400
Val Gln Tyr Ser Tyr Ser Leu Phe His Leu Met Leu Cys Leu Ala Ser 
                 405                410                415
Leu Tyr Ile Met Met Thr Leu Thr Ser Trp Tyr Ser Pro Asp Ala Lys 
             420                425                430
Phe Gln Ser Met Thr Ser Lys Trp Pro Ala Val Trp Val Lys Ile Ser 
         435                440                445
Ser Ser Trp Val Cys Leu Leu Leu Tyr Val Trp Thr Leu Val Ala Pro 
     450                455                460
Leu Val Leu Thr Ser Arg Asp Phe Ser 
 465                470



<210> 4389
<211> 665
<212> DNA
<213> Rattus norvegicus
<308> AA799641
<400> 4389

gaatcagat  aggcaaaga  tgggaactg  tttgaaatt  aggactttt  gaggtaacc  60
tggtcccct  ctgttaaaa  caggtattt  tctctcacg  ttttaagat  aagggccag  120
actatctgc  tcacaaatc  ttgttactc  gatttccac  tatgatcct  aaggttgga  180
agtggtccc  acagcccgt  aggcccagc  tcccgagcc  ccaactcta  ttagctgtc  240
atattacga  tatcagctt  attctctaa  atgtaataa  ctgacatgc  tttgacttc  300
acacactca  taacaagat  attacataa  actgcagtg  ttcccaagt  aagtgttct  360
tttaatcag  tctacaaag  atttactgg  atgacattt  tgacaaagc  acagacttc  420
atcaagcag  atcagtgta  tataaaaag  aagcaaagg  acaaaatag  cttcttctt  480
cagcctcat  agcagctgc  tttctgggg  aggacctac  cacatagta  ttccttgcc  540
agaaccagg  cctctgaag  agggaaatg  ggattaatg  attcctttt  ggtttttaa  600
gagactgta  tagaaatat  ttaaagata  ccttaaata  ccaacaatc  tctgactta  660
aactt  665



<210> 4390
<211> 472
<212> PRT
<213> Rattus norvegicus
<308> NP_036162
<400> 4390

Met Gly Ala Val Leu Ala Val Phe Ser Leu Ala Ser Trp Val Pro Cys 
  1               5                  10                  15
Leu Cys Ser Gly Ala Ser Cys Leu Leu Cys Ser Cys Cys Pro Ile Ser 
             20                  25                  30
Lys Asn Ser Thr Val Thr Arg Leu Ile Tyr Ala Phe Ile Leu Phe Leu 
         35                  40                  45
Gly Thr Ile Val Ser Cys Ile Met Met Thr Glu Gly Ile Gln Thr Gln 
     50                  55                  60
Leu Lys Lys Ile Pro Gly Phe Cys Glu Gly Gly Phe Gln Ile Lys Met 
 65                  70                  75                  80
Val Asp Thr Lys Ala Glu Lys Asp Cys Asp Val Leu Val Gly Phe Lys 
                 85                  90                  95
Ala Val Tyr Arg Ile Asn Phe Ala Val Ala Ile Phe Phe Phe Ala Phe 
             100                105                110
Phe Leu Leu Met Leu Lys Val Lys Thr Ser Lys Asp Pro Arg Ala Ala 
         115                120                125
Val His Asn Gly Phe Trp Phe Phe Lys Ile Ala Ala Ile Ile Gly Ile 
     130                135                140
Met Ile Gly Ser Phe Tyr Ile Pro Gly Gly Ser Phe Thr Glu Val Trp 
 145                150                155                160
Phe Val Ala Gly Met Leu Gly Ala Ser Phe Phe Ile Ile Ile Gln Leu 
                 165                170                175
Val Leu Leu Val Asp Met Ala His Ser Trp Asn Glu Leu Trp Val Asn 
             180                185                190
Arg Met Glu Glu Gly Asn Pro Arg Leu Trp Tyr Ala Ala Leu Leu Ser 
         195                200                205
Phe Thr Ser Leu Phe Tyr Ile Leu Ser Ile Val Phe Ala Ala Leu Leu 
     210                215                220
Tyr Val Phe Tyr Thr Lys Pro Asp Asp Cys Thr Glu Asn Lys Val Phe 
 225                230                235                240
Ile Ser Leu Asn Leu Ile Phe Cys Val Ala Val Ser Ile Val Ser Ile 
                 245                250                255
Leu Pro Lys Val Gln Glu His Gln Pro Arg Ser Gly Leu Leu Gln Ser 
             260                265                270
Ser Ile Ile Thr Leu Tyr Thr Leu Tyr Leu Thr Trp Ser Ala Met Thr 
         275                280                285
Asn Glu Pro Glu Arg Ser Cys Asn Pro Ser Leu Met Ser Ile Ile Thr 
     290                295                300
His Leu Thr Ser Pro Thr Val Ser Pro Ala Asn Ser Thr Thr Leu Ala 
 305                310                315                320
Pro Ala Tyr Arg Pro Pro Ser Gln Ser Gly His Phe Met Asn Leu Asp 
                 325                330                335
Asp Ile Trp Gly Leu Ile Ile Phe Val Phe Cys Leu Ile Tyr Ser Ser 
             340                345                350
Phe Arg Thr Ser Ser Asn Ser Gln Val Asn Lys Leu Thr Leu Ser Gly 
         355                360                365
Ser Asp Ser Val Ile Leu Gly Asp Thr Thr Asn Gly Ala Asn Asp Glu 
     370                375                380
Glu Asp Gly Gln Pro Arg Arg Ala Val Asp Asn Glu Lys Glu Gly Val 
 385                390                395                400
Gln Tyr Ser Tyr Ser Phe Phe His Leu Met Leu Cys Cys Ala Ser Leu 
                 405                410                415
Tyr Ile Met Met Thr Ile Thr Ser Trp Tyr Ser Pro Asp Ala Lys Phe 
             420                425                430
Gln Lys Val Ser Ser Lys Trp Leu Ala Val Trp Phe Lys Met Gly Ser 
         435                440                445
Ser Trp Leu Cys Leu Leu Leu Tyr Leu Trp Thr Leu Val Ala Pro Leu 
     450                455                460
Val Leu Thr Gly Arg Asp Phe Ser 
 465                470



<210> 4391
<211> 1892
<212> DNA
<213> Homo sapiens
<308> NM_006811
<400> 4391

ggcacgagc  cagctggca  ttaccaccg  gttagaaag  agcctcagg  ccggccacc  60
ccatcactg  cgtcaccat  ggggctgtg  tgggtgtct  ctccctcgc  agctgggtt  120
catgcctct  cagcggtgc  tcatgtttg  tgtgtagtt  ctgtcctaa  agtaagaat  180
ccacggtga  tcgcctcat  tatgctttc  ttctcctcc  gagcactgt  gtatcctat  240
tcatgcaga  aaaagagat  gaaacttac  tgaagaaga  tcctggatt  tgtgaaggg  300
gatttaaaa  ccatgaggc  gatataaat  cagataaag  ttgtgatgt  ctggttggt  360
ataaagctg  gtatcggat  agctttgcc  tggccatct  tttctttgt  ttttctctg  420
tcatgttca  agtaaaaac  agtaaagat  tccgagcgg  agtacacaa  gggttttgg  480
tcttcaaaa  tgctgccct  attggaatc  tggttggct  tttctacat  cctgggggc  540
atttcagct  agtctggtt  gttgttggc  tgatagggg  cgccctctt  atcctcatt  600
agctggtgc  gctggtaga  tttgctcat  cttggaatg  atcatgggt  aatcgaatg  660
aagaaggaa  cccaaggtt  tggtatgct  ctttactgt  tttcacaag  gccttttat  720
tcctgtcaa  catctgtgt  gggctgctc  atacatatt  caccaaacc  gatggctgc  780
cagaaaaca  gttcttcat  agtattaac  tgatccttt  cgttgtggc  tctattata  840
cgatccacc  aaaaattca  gaacaccag  ctcgctccg  cctcttgca  tcctccctc  900
tcaccctct  cactatgta  ctcacctgg  cagccatgt  caatgaacc  gatcgttcc  960
gcaatccca  cctgatgag  tttattaca  gcataactg  accaaccct  gctcctgga  1020
attcaactg  tgtggtccc  acccctact  caccatcaa  gagtgggtc  ttactggat  1080
cagataatt  tattggact  tttgtcttt  ttctctgcc  cttgtattc  agcatccgc  1140
cttccacta  tagccaagt  gacaagctg  ccctgtcag  gagtgacag  gtcatcctt  1200
gtgatacaa  taccagtgg  gccagtgat  aagaagatg  acagcctcg  cgggctgtg  1260
acaacgaga  agagggagt  cagtatagc  actccttat  ccacctcat  ctctgcttg  1320
cttccttgt  catcatgat  accctgacc  gctggtaca  ccctgatgc  aagtttcag  1380
gcatgacca  caagtggcc  gctgtgtgg  tcaagatca  ctccagctg  gtctgcctc  1440
tgctttacg  ctggaccct  gtggctcca  ttgtcctca  cagtcggga  ttcagctga  1500
cctctgagt  ccaaggaca  cactggaac  cacaaaggt  tccttcacc  aaaacccat  1560
tacctttta  gtttgtttc  actaaaata  taagtgaat  ctttgcaag  ttgactgta  1620
gcaggttta  atcagaagg  gagattgaa  aatgcttga  gcagaatcg  aacttctca  1680
ttatctgta  attatgttt  cttctaagg  tatagcaca  agggaacat  ttttgttta  1740
agtgaacta  agctgtgct  tgaagagag  tctttataa  gcctgtagg  tcttttaac  1800
ttggtttaa  atgtaagat  ggaaaatgt  ggatatttg  ggccatgct  aatatattt  1860
tattgcagt  tcctttaaa  gcaaaaaaa  aa  1892



<210> 4392
<211> 473
<212> PRT
<213> Homo sapiens
<308> NP_006802
<400> 4392

Met Gly Ala Val Leu Gly Val Phe Ser Leu Ala Ser Trp Val Pro Cys 
  1               5                  10                  15
Leu Cys Ser Gly Ala Ser Cys Leu Leu Cys Ser Cys Cys Pro Asn Ser 
             20                  25                  30
Lys Asn Ser Thr Val Thr Arg Leu Ile Tyr Ala Phe Ile Leu Leu Leu 
         35                  40                  45
Ser Thr Val Val Ser Tyr Ile Met Gln Arg Lys Glu Met Glu Thr Tyr 
     50                  55                  60
Leu Lys Lys Ile Pro Gly Phe Cys Glu Gly Gly Phe Lys Ile His Glu 
 65                  70                  75                  80
Ala Asp Ile Asn Ala Asp Lys Asp Cys Asp Val Leu Val Gly Tyr Lys 
                 85                  90                  95
Ala Val Tyr Arg Ile Ser Phe Ala Met Ala Ile Phe Phe Phe Val Phe 
             100                105                110
Ser Leu Leu Met Phe Lys Val Lys Thr Ser Lys Asp Leu Arg Ala Ala 
         115                120                125
Val His Asn Gly Phe Trp Phe Phe Lys Ile Ala Ala Leu Ile Gly Ile 
     130                135                140
Met Val Gly Ser Phe Tyr Ile Pro Gly Gly Tyr Phe Ser Ser Val Trp 
 145                150                155                160
Phe Val Val Gly Met Ile Gly Ala Ala Leu Phe Ile Leu Ile Gln Leu 
                 165                170                175
Val Leu Leu Val Asp Phe Ala His Ser Trp Asn Glu Ser Trp Val Asn 
             180                185                190
Arg Met Glu Glu Gly Asn Pro Arg Leu Trp Tyr Ala Ala Leu Leu Ser 
         195                200                205
Phe Thr Ser Ala Phe Tyr Ile Leu Ser Ile Ile Cys Val Gly Leu Leu 
     210                215                220
Tyr Thr Tyr Tyr Thr Lys Pro Asp Gly Cys Thr Glu Asn Lys Phe Phe 
 225                230                235                240
Ile Ser Ile Asn Leu Ile Leu Cys Val Val Ala Ser Ile Ile Ser Ile 
                 245                250                255
His Pro Lys Ile Gln Glu His Gln Pro Arg Ser Gly Leu Leu Gln Ser 
             260                265                270
Ser Leu Ile Thr Leu Tyr Thr Met Tyr Leu Thr Trp Ser Ala Met Ser 
         275                280                285
Asn Glu Pro Asp Arg Ser Cys Asn Pro Asn Leu Met Ser Phe Ile Thr 
     290                295                300
Arg Ile Thr Ala Pro Thr Leu Ala Pro Gly Asn Ser Thr Ala Val Val 
 305                310                315                320
Pro Thr Pro Thr Pro Pro Ser Lys Ser Gly Ser Leu Leu Asp Ser Asp 
                 325                330                335
Asn Phe Ile Gly Leu Phe Val Phe Val Leu Cys Leu Leu Tyr Ser Ser 
             340                345                350
Ile Arg Thr Ser Thr Asn Ser Gln Val Asp Lys Leu Thr Leu Ser Gly 
         355                360                365
Ser Asp Ser Val Ile Leu Gly Asp Thr Thr Thr Ser Gly Ala Ser Asp 
     370                375                380
Glu Glu Asp Gly Gln Pro Arg Arg Ala Val Asp Asn Glu Lys Glu Gly 
 385                390                395                400
Val Gln Tyr Ser Tyr Ser Leu Phe His Leu Met Leu Cys Leu Ala Ser 
                 405                410                415
Leu Tyr Ile Met Met Thr Leu Thr Ser Trp Tyr Ser Pro Asp Ala Lys 
             420                425                430
Phe Gln Ser Met Thr Ser Lys Trp Pro Ala Val Trp Val Lys Ile Ser 
         435                440                445
Ser Ser Trp Val Cys Leu Leu Leu Tyr Val Trp Thr Leu Val Ala Pro 
     450                455                460
Leu Val Leu Thr Ser Arg Asp Phe Ser 
 465                470



<210> 4393
<211> 591
<212> DNA
<213> Rattus norvegicus
<308> AA799645
<400> 4393

caagaagga  aaccgagtt  tattggagg  ctgagcagc  aggggtgtc  gagaagcag  60
gctgatgca  gggacgctg  aggtggtca  aggcgagca  ctgggtggg  agaggtgtc  120
ggtgccaag  gggctctgg  tgagtttcc  ggagccagg  ggaggttct  ccgcctgcg  180
gtggacaga  ggcggatgg  gctgcggaa  gttccctcc  cttcgtcgg  ttccccagt  240
ctctgctgt  ggttgaatt  gcaccggca  cttttgcta  ggatgataa  gatgcccaa  300
atgaagagg  tcccagcga  agtgaggcc  ccgatccgc  gggtgtggt  atcgtaggt  360
aatggatct  gttcctgcg  agcttctgc  ctggccatg  agaggagac  cacacagac  420
atcaggatg  ggccgggag  tgccattgc  ccttgaaag  gaagcaagc  atctccgga  480
acaggtgga  tgctgtgag  caaacagga  atgcccagc  tcacctgcc  ctacacacc  540
cagccagtg  tctctccgt  ctcaggcag  cccagttct  ctgccctcg  c  591



<210> 4394
<211> 92
<212> PRT
<213> Rattus norvegicus
<308> O08589
<400> 4394

Met Ala Pro Leu His His Ile Leu Ile Val Cys Val Cys Leu Leu Ser 
  1               5                  10                  15
Met Ala Ser Ala Glu Ala Pro Gln Glu Pro Asp Pro Phe Thr Tyr Asp 
             20                  25                  30
Tyr His Thr Leu Arg Ile Gly Gly Leu Thr Ala Gly Ile Leu Leu Phe 
         35                  40                  45
Ile Leu Gly Ile Leu Ile Ile Leu Ser Lys Arg Cys Arg Cys Lys Phe 
     50                  55                  60
Asn Gln Gln Gln Arg Thr Gly Glu Pro Asp Glu Glu Glu Gly Thr Phe 
 65                  70                  75                  80
Arg Ser Ser Ile Arg Arg Leu Ser Thr Arg Arg Arg 
                 85                  90



<210> 4395
<211> 279
<212> DNA
<213> Homo sapiens
<308> U72245
<400> 4395

atggcacct  tccaccaca  cttggtttt  tgtgtgggt  tcctcacca  ggccaaggc  60
gaaagtcca  aggaacacg  cccgttcac  tacgactac  agtccctgc  gatcggagg  120
ctcgtcatc  ccgggatcc  cttcatcct  ggcatcctc  tcgtgctga  cagaagatg  180
cggtgcaag  tcaaccagc  gcagaggac  ggggaaccc  atgaagagg  gggaacttt  240
cgcagctcc  tccgccgtc  gtccacccg  aggcggtag  279



<210> 4396
<211> 92
<212> PRT
<213> Homo sapiens
<308> O00168
<400> 4396

Met Ala Pro Leu His His Ile Leu Val Phe Cys Val Gly Leu Leu Thr 
  1               5                  10                  15
Met Ala Lys Ala Glu Ser Pro Lys Glu His Asp Pro Phe Thr Tyr Asp 
             20                  25                  30
Tyr Gln Ser Leu Gln Ile Gly Gly Leu Val Ile Ala Gly Ile Leu Phe 
         35                  40                  45
Ile Leu Gly Ile Leu Ile Val Leu Ser Arg Arg Cys Arg Cys Lys Phe 
     50                  55                  60
Asn Gln Gln Gln Arg Thr Gly Glu Pro Asp Glu Glu Glu Gly Thr Phe 
 65                  70                  75                  80
Arg Ser Ser Ile Arg Arg Leu Ser Thr Arg Arg Arg 
                 85                  90



<210> 4397
<211> 591
<212> DNA
<213> Rattus norvegicus
<308> AA799645
<400> 4397

caagaagga  aaccgagtt  tattggagg  ctgagcagc  aggggtgtc  gagaagcag  60
gctgatgca  gggacgctg  aggtggtca  aggcgagca  ctgggtggg  agaggtgtc  120
ggtgccaag  gggctctgg  tgagtttcc  ggagccagg  ggaggttct  ccgcctgcg  180
gtggacaga  ggcggatgg  gctgcggaa  gttccctcc  cttcgtcgg  ttccccagt  240
ctctgctgt  ggttgaatt  gcaccggca  cttttgcta  ggatgataa  gatgcccaa  300
atgaagagg  tcccagcga  agtgaggcc  ccgatccgc  gggtgtggt  atcgtaggt  360
aatggatct  gttcctgcg  agcttctgc  ctggccatg  agaggagac  cacacagac  420
atcaggatg  ggccgggag  tgccattgc  ccttgaaag  gaagcaagc  atctccgga  480
acaggtgga  tgctgtgag  caaacagga  atgcccagc  tcacctgcc  ctacacacc  540
cagccagtg  tctctccgt  ctcaggcag  cccagttct  ctgccctcg  c  591



<210> 4398
<211> 92
<212> PRT
<213> Rattus norvegicus
<308> O08589
<400> 4398

Met Ala Pro Leu His His Ile Leu Ile Val Cys Val Cys Leu Leu Ser 
  1               5                  10                  15
Met Ala Ser Ala Glu Ala Pro Gln Glu Pro Asp Pro Phe Thr Tyr Asp 
             20                  25                  30
Tyr His Thr Leu Arg Ile Gly Gly Leu Thr Ala Gly Ile Leu Leu Phe 
         35                  40                  45
Ile Leu Gly Ile Leu Ile Ile Leu Ser Lys Arg Cys Arg Cys Lys Phe 
     50                  55                  60
Asn Gln Gln Gln Arg Thr Gly Glu Pro Asp Glu Glu Glu Gly Thr Phe 
 65                  70                  75                  80
Arg Ser Ser Ile Arg Arg Leu Ser Thr Arg Arg Arg 
                 85                  90



<210> 4399
<211> 279
<212> DNA
<213> Homo sapiens
<308> U72245
<400> 4399

atggcacct  tccaccaca  cttggtttt  tgtgtgggt  tcctcacca  ggccaaggc  60
gaaagtcca  aggaacacg  cccgttcac  tacgactac  agtccctgc  gatcggagg  120
ctcgtcatc  ccgggatcc  cttcatcct  ggcatcctc  tcgtgctga  cagaagatg  180
cggtgcaag  tcaaccagc  gcagaggac  ggggaaccc  atgaagagg  gggaacttt  240
cgcagctcc  tccgccgtc  gtccacccg  aggcggtag  279



<210> 4400
<211> 92
<212> PRT
<213> Homo sapiens
<308> O00168
<400> 4400

Met Ala Pro Leu His His Ile Leu Val Phe Cys Val Gly Leu Leu Thr 
  1               5                  10                  15
Met Ala Lys Ala Glu Ser Pro Lys Glu His Asp Pro Phe Thr Tyr Asp 
             20                  25                  30
Tyr Gln Ser Leu Gln Ile Gly Gly Leu Val Ile Ala Gly Ile Leu Phe 
         35                  40                  45
Ile Leu Gly Ile Leu Ile Val Leu Ser Arg Arg Cys Arg Cys Lys Phe 
     50                  55                  60
Asn Gln Gln Gln Arg Thr Gly Glu Pro Asp Glu Glu Glu Gly Thr Phe 
 65                  70                  75                  80
Arg Ser Ser Ile Arg Arg Leu Ser Thr Arg Arg Arg 
                 85                  90



<210> 4401
<211> 641
<212> DNA
<213> Rattus norvegicus
<308> AA799650
<400> 4401

gatgtcaag  atcttaatg  ttattttta  tctttacat  cagcacttg  agaaaagaa  60
atgacatag  gttttagaa  catagtcct  catgattat  actcatcaa  accttagaa  120
acacaagga  actgtgagt  aatgactac  ctaaaaaat  atgggaaat  cagcataat  180
aacaaaaat  caagaggaa  tttcaggac  ttgatcaga  gctttcact  agtgctggc  240
ctatatgct  cttcatttc  ctaagtgct  gcgctatgt  ctacttcat  tcactaagt  300
ctggtgcta  gtgctactt  actgtagac  aagcttcag  gcaggctaa  aaatcttaa  360
cctctgaag  catgatcta  gaaatgggg  ccaagcact  gtagagaat  ggtagccat  420
aagaagtcc  tagtaagga  agctatgga  ggagctggc  acctttaac  tgaacctgt  480
ttaaaatta  aaagcccat  gagcagtac  tataaacac  agcatggtg  ggttttgcc  540
ttctataaa  aatcttcag  attccagct  gggctctct  ttggcatga  aagcttcag  600
taaacagca  acataggat  acctattat  gatggacct  c  641



<210> 4402
<211> 257
<212> PRT
<213> Rattus norvegicus
<308> NP_071985
<400> 4402

Met Ala Ala Ala Ala Gly Arg Leu Leu Trp Ser Ser Val Ala Arg Pro 
  1               5                  10                  15
Ala Ser Thr Ile Phe Arg Ser Ile Ser Ala Ser Thr Val Leu Arg Pro 
             20                  25                  30
Val Ala Ser Arg Arg Thr Cys Leu Thr Asp Met Leu Trp Ser Ala Cys 
         35                  40                  45
Pro Gln Ala Lys Phe Ala Phe Ser Thr Ser Ser Ser Phe His Thr Pro 
     50                  55                  60
Ala Val Thr Gln His Ala Pro His Phe Lys Gly Thr Ala Val Val Asn 
 65                  70                  75                  80
Gly Glu Phe Lys Glu Leu Ser Leu Asp Asp Phe Lys Gly Lys Tyr Leu 
                 85                  90                  95
Val Leu Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu 
             100                105                110
Ile Val Ala Phe Ser Asp Lys Ala Asn Glu Phe His Asp Val Asn Cys 
         115                120                125
Glu Val Val Ala Val Ser Val Asp Ser His Phe Ser His Leu Ala Trp 
     130                135                140
Ile Asn Thr Pro Arg Lys Asn Gly Gly Leu Gly His Met Asn Ile Thr 
 145                150                155                160
Leu Leu Ser Asp Leu Thr Lys Gln Ile Ser Arg Asp Tyr Gly Val Leu 
                 165                170                175
Leu Glu Ser Ala Gly Ile Ala Leu Arg Gly Leu Phe Ile Ile Asp Pro 
             180                185                190
Asn Gly Val Ile Lys His Leu Ser Val Asn Asp Leu Pro Val Gly Arg 
         195                200                205
Ser Val Glu Glu Pro Leu Arg Leu Val Lys Ala Phe Gln Phe Val Glu 
     210                215                220
Thr His Gly Glu Val Cys Pro Pro Asn Trp Thr Pro Glu Ser Pro Thr 
 225                230                235                240
Ile Lys Pro Ser Pro Thr Ala Ser Lys Glu Tyr Phe Glu Lys Val His 
                 245                250                255
Gln 
             260



<210> 4403
<211> 1542
<212> DNA
<213> Homo sapiens
<308> NM_006793
<400> 4403

ctgaagatg  cggctgctg  aggacggtt  ctccgagcg  cggttgccc  acatgtgag  60
gccattcct  ggggcattt  tgccactgc  gccctcagg  ctgctgcat  tggaagaac  120
agcttgaca  atttattgt  ttctggttc  agtcaagca  aattattca  caccagttc  180
tcatgccat  cacctgctg  cacccagca  gcaccctat  ttaagggta  agccgttgt  240
aatggagag  tcaaagacc  aagccttga  gactttaag  ggaaatatt  ggtgctttt  300
ttctatcct  tggatttca  ctttgtgtg  cctacagaa  ttgttgctt  tagtgacaa  360
gctaacgaa  ttcacgatg  gaactgtga  gttgtcgca  tctcagtgg  ttcccactt  420
agccatctt  cctggataa  tacaccaag  aagaatggt  gtttgggcc  catgaacat  480
gcactcttg  cagacttaa  taagcagat  tcccgagac  acggtgtgc  gttagaagg  540
tctggtctt  cactaagag  tctcttcat  attgacccc  atggagtca  caagcattt  600
agcgtcaac  atctcccag  gggccgaag  gtggaagaa  ccctccgct  ggtgaaggc  660
ttccagtat  tagaaacac  tggagaagt  tgcccagcg  actggacac  ggattctcc  720
acgatcaag  caagtccag  tgcttccaa  gagtacttt  agaaggtaa  tcagtagat  780
acccatgtg  atctgcacc  tctcaactg  gagaagaac  acagttgaa  cctgctttt  840
tcattttca  gatggttat  tgtagaagg  aaggaacca  ttatgcttg  attcataag  900
attactcta  atgttttgt  tttgtaatt  tggctagga  cttttaaac  tggttagtt  960
ctagtacag  aatcgttta  tggtaacat  ttggtggct  gctagctag  ttctacaga  1020
cataatttg  ctctataga  ggctattct  agatcatgt  tcaatggaa  cactcttct  1080
tcttagcct  acttgaatc  tgcctataa  aaagtagag  aacacacat  gaaagcttc  1140
gatcaacgg  cctgaaatt  tcatcttga  tgtctttgt  ttaaactga  ttttctttt  1200
agctaacaa  gatcataat  ttcaatgat  agccgtgta  ctcctgcaa  gaatgttta  1260
gtgattgaa  caaatgtga  tcgtattat  ttaaaaagt  gcagagtga  ttaactgat  1320
atgcatgat  cctcatccc  gaaattgag  ttatgtagt  attttactt  ttttattca  1380
tagctaact  tgtctatgt  tatttctag  tattgatta  tgtaatcga  tataaagga  1440
atttatcaa  tccagggat  gcattttga  attataatt  ttttctttg  tgaagtatt  1500
attgtaaaa  atacaaata  catatttaa  caaaaaaaa  aa  1542



<210> 4404
<211> 256
<212> PRT
<213> Homo sapiens
<308> P30048
<400> 4404

Met Ala Ala Ala Val Gly Arg Leu Leu Arg Ala Ser Val Ala Arg His 
  1               5                  10                  15
Val Ser Ala Ile Pro Trp Gly Ile Ser Ala Thr Ala Ala Leu Arg Pro 
             20                  25                  30
Ala Ala Cys Gly Arg Thr Ser Leu Thr Asn Leu Leu Cys Ser Gly Ser 
         35                  40                  45
Ser Gln Ala Lys Leu Phe Ser Thr Ser Ser Ser Cys His Ala Pro Ala 
     50                  55                  60
Val Thr Gln His Ala Pro Tyr Phe Lys Gly Thr Ala Val Val Asn Gly 
 65                  70                  75                  80
Glu Phe Lys Asp Leu Ser Leu Asp Asp Phe Lys Gly Lys Tyr Leu Val 
                 85                  90                  95
Leu Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
             100                105                110
Val Ala Phe Ser Asp Lys Ala Asn Glu Phe His Asp Val Asn Cys Glu 
         115                120                125
Val Val Ala Val Ser Val Asp Ser His Phe Ser His Leu Ala Trp Ile 
     130                135                140
Asn Thr Pro Arg Lys Asn Gly Gly Leu Gly His Met Asn Ile Ala Leu 
 145                150                155                160
Leu Ser Asp Leu Thr Lys Gln Ile Ser Arg Asp Tyr Gly Val Leu Leu 
                 165                170                175
Glu Gly Ser Gly Leu Ala Leu Arg Gly Leu Phe Ile Ile Asp Pro Asn 
             180                185                190
Gly Val Ile Lys His Leu Ser Val Asn Asp Leu Pro Val Gly Arg Ser 
         195                200                205
Val Glu Glu Thr Leu Arg Leu Val Lys Ala Phe Gln Tyr Val Glu Thr 
     210                215                220
His Gly Glu Val Cys Pro Ala Asn Trp Thr Pro Asp Ser Pro Thr Ile 
 225                230                235                240
Lys Pro Ser Pro Ala Ala Ser Lys Glu Tyr Phe Gln Lys Val Asn Gln 
                 245                250                255



<210> 4405
<211> 520
<212> DNA
<213> Rattus norvegicus
<308> AA799654
<400> 4405

ttcaggccc  aacagttca  gagtgcagc  tgcagcacc  atggtccac  gcaggccac  60
ccatcagta  caagacccg  attatcaga  accggtgcc  gtggcctgc  acccagggt  120
cactcaaga  gccaagggt  tgggtttgg  tgagtatga  aggtaccag  cagaggtca  180
cttggggct  tgtgagctg  ccaacccaa  ggaagaggg  aggtgaaca  ggtttccag  240
gtcccgtgt  ccccacggc  gccaagagg  taacatggg  tctctggtg  tgccaacaa  300
gcctaccct  gtgctaagc  tgcggctga  tgagcaggt  gtgtgttgg  gtcaggatg  360
ccctcctaa  gcgttactg  tataagcta  tctgtccca  ggcagtaag  aaccacagg  420
gacattttc  ccacgaggt  ccaatgggt  aaatcactg  agccttcag  gcctatggc  480
ggcacacca  gggaacaag  gcgtgggcg  gggtgtggag  520



<210> 4406
<211> 573
<212> PRT
<213> Rattus norvegicus
<308> AAH10776
<400> 4406

Met Asp Glu Gly Gly Leu Pro Leu Leu Pro Asp Ser Leu Val Tyr Gln 
  1               5                  10                  15
Ile Phe Leu Ser Leu Gly Pro Ala Asp Val Leu Ala Ala Gly Leu Val 
             20                  25                  30
Cys Arg Gln Trp Gln Ala Val Ser Arg Asp Glu Phe Leu Trp Lys Glu 
         35                  40                  45
Gln Phe Tyr Arg Tyr Tyr Gln Val Ala Arg Asp Val Pro Arg His Pro 
     50                  55                  60
Ala Ala Thr Ser Trp Tyr Glu Glu Phe Arg Arg Leu Tyr Asp Met Val 
 65                  70                  75                  80
Pro Cys Val Glu Val Gln Thr Leu Lys Glu His Thr Asp Gln Val Leu 
                 85                  90                  95
His Leu Ser Phe Ser His Ser Gly Tyr Gln Phe Ala Ser Cys Ser Lys 
             100                105                110
Asp Cys Thr Val Lys Ile Trp Asn Asn Asp Leu Thr Ile Ser Leu Leu 
         115                120                125
His Ser Ala Asp Met Arg Pro Tyr Asn Trp Ser Tyr Thr Gln Phe Ser 
     130                135                140
Gln Phe Asn Gln Asp Asp Ser Leu Leu Leu Ala Ser Gly Val Phe Leu 
 145                150                155                160
Gly Pro His Asn Ser Ser Ser Gly Glu Ile Ala Val Ile Ser Leu Asp 
                 165                170                175
Ser Phe Ala Leu Leu Ser Arg Val Arg Asn Lys Pro Tyr Asp Val Phe 
             180                185                190
Gly Cys Trp Leu Thr Glu Thr Ser Leu Ile Ser Gly Asn Leu His Arg 
         195                200                205
Ile Gly Asp Ile Thr Ser Cys Ser Val Leu Trp Leu Asn Asn Ala Phe 
     210                215                220
Gln Asp Val Glu Ser Glu Asn Val Asn Val Val Lys Arg Leu Phe Lys 
 225                230                235                240
Ile Gln Asn Leu Asn Ala Ser Thr Ile Arg Thr Val Met Val Ala Asp 
                 245                250                255
Cys Ser Arg Phe Asp Ser Pro Asp Leu Leu Leu Asp Ala Ser Asp Gln 
             260                265                270
Ala Gly Leu Pro Cys Arg Val Phe Asp Leu Gly Gly Asp Thr Glu Glu 
         275                280                285
Glu Ala Thr Asp Pro Gly Leu His Thr Ser Gly Ser Asp His Val Lys 
     290                295                300
Lys Gly Leu Arg Arg Val Phe Asp Ser Val Leu Asp Gly His Gly Gln 
 305                310                315                320
Leu Ser Asp Cys Ala Leu Glu Thr Lys Val Ala Glu Leu Leu Ala Gln 
                 325                330                335
Gly His Thr Lys Pro Pro Glu Cys Asn Asp Ala Asp Thr Arg Asn Lys 
             340                345                350
Tyr Leu Ile Phe Thr Thr Gly Cys Leu Thr Tyr Ser Pro His Gln Ile 
         355                360                365
Gly Ile Lys Gln Ile Leu Pro His Gln Met Thr Thr Ala Gly Pro Val 
     370                375                380
Leu Gly Glu Gly Arg Gly Ser Asp Ala Phe Phe Asp Ala Leu Asp His 
 385                390                395                400
Val Ile Asp Val His Gly His Ile Ile Gly Met Gly Leu Ser Pro Asp 
                 405                410                415
Asn Arg Tyr Leu Tyr Val Asn Ser Arg Ala Trp Pro Pro Gly Ser Val 
             420                425                430
Val Ala Asp Pro Met Gln Pro Pro Pro Ile Ala Glu Glu Ile Asp Leu 
         435                440                445
Leu Val Phe Asp Leu Lys Thr Met Arg Glu Val Lys Arg Ala Leu Arg 
     450                455                460
Ala His Arg Ala Tyr Thr Pro Asn Asp Glu Cys Phe Phe Ile Phe Leu 
 465                470                475                480
Asp Val Ser Arg Asp Phe Val Ala Ser Gly Ala Glu Asp Arg His Gly 
                 485                490                495
Tyr Ile Trp Asp Arg His Tyr Asn Ile Cys Leu Ala Lys Leu Arg His 
             500                505                510
Glu Asp Val Val Asn Ser Val Ala Phe Ser Pro Gln Glu Gln Glu Leu 
         515                520                525
Leu Leu Thr Ala Ser Asp Asp Ala Thr Ile Lys Ala Trp Arg Ser Pro 
     530                535                540
Arg Ile Val Arg Val Leu Gln Ala Pro Arg Pro Arg Pro Arg Pro Arg 
 545                550                555                560
Pro Arg Pro Phe Phe Ser Trp Phe Ala Ser His Arg Arg 
                 565                570



<210> 4407
<211> 1966
<212> DNA
<213> Homo sapiens
<308> AL137631
<400> 4407

ggaacaagc  ctatgacgt  tttggctgt  ggctcaccg  gaccagcct  atctcgggg  60
acctgcacc  catcggaga  atcacctcc  gctcggtgc  gtggctcaa  aatgccttc  120
aggatgtgg  gtcagagaa  gtcaacgtg  tgaagcggc  gttcaagat  cagaacctc  180
atgccagca  cgtccgcac  gtgatggtg  ccgactgca  ccgcttcga  agccctgac  240
tgctgctgg  agccggtga  ccggccacg  ccccctgcc  catctttga  ctgggcagc  300
acaacgagg  ggtggtggc  ggcccggcc  ccgcccacg  caaggaggg  ttgcggcac  360
ttctggacc  cgtgctgga  gggcgggcg  agccacagc  gtcggagcg  atgctagag  420
ccaaggtgg  cgagctgct  gcccagggc  acaccaagc  acccgagcg  agtgccaca  480
gcgccaaga  caagtacct  atcttcacc  ctggctgcc  cacctactc  ccacaccag  540
tcggtacac  cctgccgcc  tgctgcccg  ctcggtcct  ggagcttgg  ggaggccgg  600
caggggtcc  gaggggcag  cagcaagca  gtccacagg  aaagctggg  tcgttcact  660
gcccctggg  tcacaagct  agacctggg  cctgtggga  gagcagtga  aacaaacgc  720
ggcagggcc  ctggccagc  agcaaccga  gggcctgat  caggtctgg  gcccccgga  780
caggcagtg  ccacggacc  ctgtggtgc  cacagcccc  gagacacca  tgaggcatc  840
agcagatcc  gccacacca  atgaccacg  cagggcccg  gctgggtga  ggccggggc  900
ccgatgcct  cttcgacgc  ctggaccac  tcatagaca  acacggaca  atcatcggc  960
tgggcctgt  gcccgacaa  aggtacctg  acgtgaaca  ccgcgcctg  cccaacggt  1020
cggtggtgg  cgaccccat  cagccgcca  caatcgcgg  ggagattga  ctgctggtg  1080
tcgacctca  gaccatgcg  gaggtgagg  gggctctgc  tgcgcaccg  gcctacacg  1140
ccaacgacg  gtgcttctt  atcttcctg  acgtcagca  ggacttcgt  gccagcggg  1200
cggaggacc  gcacggcta  atctgggac  gccactaca  catctgtct  gccaggctg  1260
ggcacgagg  tgtggtcaa  tcagtggtc  tcagtcccc  ggagcagga  ctgctgctc  1320
cggccagcg  cgacgccac  atcaaagcc  ggcgctccc  acgcaccat  cgcgtcctc  1380
aggcacctc  cccacggcc  cgcaccttc  tctcctggc  tgccagcca  aggcgctga  1440
gtgtgctgg  tgcactgga  ccaccggga  cccttgagg  catcgccag  ctctgtggc  1500
ttttcccga  cgggagagg  ggagatgct  atagcagtt  cgccttagg  aggggacaa  1560
caggccccg  cacacgctc  cacacaaac  tgctcacgc  gctgtgatg  ttggcacgg  1620
gtggccagt  cagatggag  ccaaggccc  ctcggcctc  tgggcaact  ggggtacac  1680
ggatactgg  ggtgccgct  ctcactcaa  cccaggcta  gggtacacc  gacccagct  1740
gcctcggcc  ggggcacct  cggctggtc  tgtggggcc  tggacggtg  cccagtggt  1800
gcaggggct  ctcctggct  tggttgtgc  cccggggct  gggagcggc  ggtcacgct  1860
ctgtgggcc  gagtgtgtt  catgtccac  caccacccg  tcagggccc  gaataaaca  1920
ttggcaaca  caaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaa  1966



<210> 4408
<211> 520
<212> DNA
<213> Rattus norvegicus
<308> AA799654
<400> 4408

ttcaggccc  aacagttca  gagtgcagc  tgcagcacc  atggtccac  gcaggccac  60
ccatcagta  caagacccg  attatcaga  accggtgcc  gtggcctgc  acccagggt  120
cactcaaga  gccaagggt  tgggtttgg  tgagtatga  aggtaccag  cagaggtca  180
cttggggct  tgtgagctg  ccaacccaa  ggaagaggg  aggtgaaca  ggtttccag  240
gtcccgtgt  ccccacggc  gccaagagg  taacatggg  tctctggtg  tgccaacaa  300
gcctaccct  gtgctaagc  tgcggctga  tgagcaggt  gtgtgttgg  gtcaggatg  360
ccctcctaa  gcgttactg  tataagcta  tctgtccca  ggcagtaag  aaccacagg  420
gacattttc  ccacgaggt  ccaatgggt  aaatcactg  agccttcag  gcctatggc  480
ggcacacca  gggaacaag  gcgtgggcg  gggtgtggag  520



<210> 4409
<211> 573
<212> PRT
<213> Rattus norvegicus
<308> AAH10776
<400> 4409

Met Asp Glu Gly Gly Leu Pro Leu Leu Pro Asp Ser Leu Val Tyr Gln 
  1               5                  10                  15
Ile Phe Leu Ser Leu Gly Pro Ala Asp Val Leu Ala Ala Gly Leu Val 
             20                  25                  30
Cys Arg Gln Trp Gln Ala Val Ser Arg Asp Glu Phe Leu Trp Lys Glu 
         35                  40                  45
Gln Phe Tyr Arg Tyr Tyr Gln Val Ala Arg Asp Val Pro Arg His Pro 
     50                  55                  60
Ala Ala Thr Ser Trp Tyr Glu Glu Phe Arg Arg Leu Tyr Asp Met Val 
 65                  70                  75                  80
Pro Cys Val Glu Val Gln Thr Leu Lys Glu His Thr Asp Gln Val Leu 
                 85                  90                  95
His Leu Ser Phe Ser His Ser Gly Tyr Gln Phe Ala Ser Cys Ser Lys 
             100                105                110
Asp Cys Thr Val Lys Ile Trp Asn Asn Asp Leu Thr Ile Ser Leu Leu 
         115                120                125
His Ser Ala Asp Met Arg Pro Tyr Asn Trp Ser Tyr Thr Gln Phe Ser 
     130                135                140
Gln Phe Asn Gln Asp Asp Ser Leu Leu Leu Ala Ser Gly Val Phe Leu 
 145                150                155                160
Gly Pro His Asn Ser Ser Ser Gly Glu Ile Ala Val Ile Ser Leu Asp 
                 165                170                175
Ser Phe Ala Leu Leu Ser Arg Val Arg Asn Lys Pro Tyr Asp Val Phe 
             180                185                190
Gly Cys Trp Leu Thr Glu Thr Ser Leu Ile Ser Gly Asn Leu His Arg 
         195                200                205
Ile Gly Asp Ile Thr Ser Cys Ser Val Leu Trp Leu Asn Asn Ala Phe 
     210                215                220
Gln Asp Val Glu Ser Glu Asn Val Asn Val Val Lys Arg Leu Phe Lys 
 225                230                235                240
Ile Gln Asn Leu Asn Ala Ser Thr Ile Arg Thr Val Met Val Ala Asp 
                 245                250                255
Cys Ser Arg Phe Asp Ser Pro Asp Leu Leu Leu Asp Ala Ser Asp Gln 
             260                265                270
Ala Gly Leu Pro Cys Arg Val Phe Asp Leu Gly Gly Asp Thr Glu Glu 
         275                280                285
Glu Ala Thr Asp Pro Gly Leu His Thr Ser Gly Ser Asp His Val Lys 
     290                295                300
Lys Gly Leu Arg Arg Val Phe Asp Ser Val Leu Asp Gly His Gly Gln 
 305                310                315                320
Leu Ser Asp Cys Ala Leu Glu Thr Lys Val Ala Glu Leu Leu Ala Gln 
                 325                330                335
Gly His Thr Lys Pro Pro Glu Cys Asn Asp Ala Asp Thr Arg Asn Lys 
             340                345                350
Tyr Leu Ile Phe Thr Thr Gly Cys Leu Thr Tyr Ser Pro His Gln Ile 
         355                360                365
Gly Ile Lys Gln Ile Leu Pro His Gln Met Thr Thr Ala Gly Pro Val 
     370                375                380
Leu Gly Glu Gly Arg Gly Ser Asp Ala Phe Phe Asp Ala Leu Asp His 
 385                390                395                400
Val Ile Asp Val His Gly His Ile Ile Gly Met Gly Leu Ser Pro Asp 
                 405                410                415
Asn Arg Tyr Leu Tyr Val Asn Ser Arg Ala Trp Pro Pro Gly Ser Val 
             420                425                430
Val Ala Asp Pro Met Gln Pro Pro Pro Ile Ala Glu Glu Ile Asp Leu 
         435                440                445
Leu Val Phe Asp Leu Lys Thr Met Arg Glu Val Lys Arg Ala Leu Arg 
     450                455                460
Ala His Arg Ala Tyr Thr Pro Asn Asp Glu Cys Phe Phe Ile Phe Leu 
 465                470                475                480
Asp Val Ser Arg Asp Phe Val Ala Ser Gly Ala Glu Asp Arg His Gly 
                 485                490                495
Tyr Ile Trp Asp Arg His Tyr Asn Ile Cys Leu Ala Lys Leu Arg His 
             500                505                510
Glu Asp Val Val Asn Ser Val Ala Phe Ser Pro Gln Glu Gln Glu Leu 
         515                520                525
Leu Leu Thr Ala Ser Asp Asp Ala Thr Ile Lys Ala Trp Arg Ser Pro 
     530                535                540
Arg Ile Val Arg Val Leu Gln Ala Pro Arg Pro Arg Pro Arg Pro Arg 
 545                550                555                560
Pro Arg Pro Phe Phe Ser Trp Phe Ala Ser His Arg Arg 
                 565                570



<210> 4410
<211> 1966
<212> DNA
<213> Homo sapiens
<308> AL137631
<400> 4410

ggaacaagc  ctatgacgt  tttggctgt  ggctcaccg  gaccagcct  atctcgggg  60
acctgcacc  catcggaga  atcacctcc  gctcggtgc  gtggctcaa  aatgccttc  120
aggatgtgg  gtcagagaa  gtcaacgtg  tgaagcggc  gttcaagat  cagaacctc  180
atgccagca  cgtccgcac  gtgatggtg  ccgactgca  ccgcttcga  agccctgac  240
tgctgctgg  agccggtga  ccggccacg  ccccctgcc  catctttga  ctgggcagc  300
acaacgagg  ggtggtggc  ggcccggcc  ccgcccacg  caaggaggg  ttgcggcac  360
ttctggacc  cgtgctgga  gggcgggcg  agccacagc  gtcggagcg  atgctagag  420
ccaaggtgg  cgagctgct  gcccagggc  acaccaagc  acccgagcg  agtgccaca  480
gcgccaaga  caagtacct  atcttcacc  ctggctgcc  cacctactc  ccacaccag  540
tcggtacac  cctgccgcc  tgctgcccg  ctcggtcct  ggagcttgg  ggaggccgg  600
caggggtcc  gaggggcag  cagcaagca  gtccacagg  aaagctggg  tcgttcact  660
gcccctggg  tcacaagct  agacctggg  cctgtggga  gagcagtga  aacaaacgc  720
ggcagggcc  ctggccagc  agcaaccga  gggcctgat  caggtctgg  gcccccgga  780
caggcagtg  ccacggacc  ctgtggtgc  cacagcccc  gagacacca  tgaggcatc  840
agcagatcc  gccacacca  atgaccacg  cagggcccg  gctgggtga  ggccggggc  900
ccgatgcct  cttcgacgc  ctggaccac  tcatagaca  acacggaca  atcatcggc  960
tgggcctgt  gcccgacaa  aggtacctg  acgtgaaca  ccgcgcctg  cccaacggt  1020
cggtggtgg  cgaccccat  cagccgcca  caatcgcgg  ggagattga  ctgctggtg  1080
tcgacctca  gaccatgcg  gaggtgagg  gggctctgc  tgcgcaccg  gcctacacg  1140
ccaacgacg  gtgcttctt  atcttcctg  acgtcagca  ggacttcgt  gccagcggg  1200
cggaggacc  gcacggcta  atctgggac  gccactaca  catctgtct  gccaggctg  1260
ggcacgagg  tgtggtcaa  tcagtggtc  tcagtcccc  ggagcagga  ctgctgctc  1320
cggccagcg  cgacgccac  atcaaagcc  ggcgctccc  acgcaccat  cgcgtcctc  1380
aggcacctc  cccacggcc  cgcaccttc  tctcctggc  tgccagcca  aggcgctga  1440
gtgtgctgg  tgcactgga  ccaccggga  cccttgagg  catcgccag  ctctgtggc  1500
ttttcccga  cgggagagg  ggagatgct  atagcagtt  cgccttagg  aggggacaa  1560
caggccccg  cacacgctc  cacacaaac  tgctcacgc  gctgtgatg  ttggcacgg  1620
gtggccagt  cagatggag  ccaaggccc  ctcggcctc  tgggcaact  ggggtacac  1680
ggatactgg  ggtgccgct  ctcactcaa  cccaggcta  gggtacacc  gacccagct  1740
gcctcggcc  ggggcacct  cggctggtc  tgtggggcc  tggacggtg  cccagtggt  1800
gcaggggct  ctcctggct  tggttgtgc  cccggggct  gggagcggc  ggtcacgct  1860
ctgtgggcc  gagtgtgtt  catgtccac  caccacccg  tcagggccc  gaataaaca  1920
ttggcaaca  caaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaa  1966



<210> 4411
<211> 610
<212> DNA
<213> Rattus norvegicus
<308> AA799656
<400> 4411

ttttcaaca  tttaaataa  aatttttcc  catgatgtt  agtgaatgt  attttcttt  60
agaatatct  ttttttcat  aaaataatt  ctgaaccac  ctatatgct  gaccttctg  120
ctaacgctc  gatatgggt  tttcgagag  ccacaggtc  ccagctcca  gaacaggcg  180
attggtcct  gcttgggga  atcctccag  tgcttctcc  aaaatatat  ctcatggaa  240
tctgagcca  catcgtcaa  acctgcttc  ttgttaact  ggaactccc  cagtttccc  300
tcctttgtc  actgtatca  ctcctcaaa  ccattccca  acggctgtt  gcttactgt  360
gctaattgc  tagcaaatt  tatctccca  agagaaggt  ctgcttctg  ttcaggtgc  420
tcgtcgtca  acgccttaa  atcaaaaat  gaaagtctt  tccccttga  caaacattt  480
ctccttctg  aatcagctg  cttctcctg  ctaagcgaa  tgtccactt  ttcgtcaaa  540
tgaatctgg  gctgtggtc  tgaactaac  ctcatcgaa  gggatttgg  aattttcat  600
ttcgatatta  610



<210> 4412
<211> 1202
<212> DNA
<213> Homo sapiens
<308> Z68747
<400> 4412

cggcgatgt  tcctagagt  tcgacgttc  tacctcttc  ccccctttc  cgccaccct  60
tgtcctctg  aagcccgga  acatcagcg  ctgcgatta  gctactcac  gttcggcac  120
gaacagtca  gtaccgcag  tcagcgctg  tggcccgga  aaaaaataa  atccaaaga  180
attttggca  taacagtgt  atctgtagc  agaaagata  gcagtctgt  cgaactgag  240
agacttcca  ggagacttc  gagagccaa  acagtgaaa  ggaaaatac  aaaaaagac  300
tgttaggca  tattaaggg  atgaaagtt  aattaagca  agtaaatgt  cgaacaaca  360
agcccccca  aagaagacc  cttaaaagt  tggaagcta  acttggcag  cttcgaaga  420
ctacagaat  tgctccaaa  aagagaatt  agcccctga  tcctgagtt  gtggcagct  480
catctgctg  ggcagattc  ctccctttt  ataagcaaa  aaccaagtc  gagctgctg  540
gccagctcc  gcagcatga  gaagagtca  gggcacaga  agatgcaaa  cgacctaaa  600
ttagtttca  taacataat  tcagatatg  aagttgcca  atctgctac  gctagagtt  660
gttcaagac  agagcttcg  attcagttt  atgaaggct  tgacaatta  cctggccag  720
agaagacgg  tgatcttaa  aaaaggaaa  atatattca  agggaaaag  cttaatatt  780
ttgacatga  ggcagttac  aaagaagca  ctgaaacag  cacatcacc  tcactttgg  840
atgtggaat  tgctaagca  ttagccaca  taaatgaac  accccttca  aatggattt  900
aagagctga  ccagtggac  aaagagggg  aactatggg  gttcccaat  aacaatgaa  960
caggttttg  tgatgatgg  tcagaattt  atgaacata  atttctgga  aaacacctg  1020
agagctttc  aaaacaagg  ccaattcgc  acttcatgg  gctggtgac  tgtggcctt  1080
ccaaaaacc  atatcttag  gttaaacag  aggttgaac  catagagtg  tttagaaat  1140
attttaatg  aaaaaagga  attctaaaa  aaagtaaca  acagttcaa  taagaccat  1200
ga  1202



<210> 4413
<211> 396
<212> PRT
<213> Homo sapiens
<308> Z68747
<400> 4413

Met Phe Pro Arg Val Ser Thr Phe Leu Pro Leu Arg Pro Leu Ser Arg 
  1               5                  10                  15
His Pro Leu Ser Ser Gly Ser Pro Glu Thr Ser Ala Ala Ala Ile Met 
             20                  25                  30
Leu Leu Thr Val Arg His Gly Thr Val Arg Tyr Arg Ser Ser Ala Leu 
         35                  40                  45
Leu Ala Arg Thr Lys Asn Asn Ile Gln Arg Tyr Phe Gly Thr Asn Ser 
     50                  55                  60
Val Ile Cys Ser Lys Lys Asp Lys Gln Ser Val Arg Thr Glu Glu Thr 
 65                  70                  75                  80
Ser Lys Glu Thr Ser Glu Ser Gln Asp Ser Glu Lys Glu Asn Thr Lys 
                 85                  90                  95
Lys Asp Leu Leu Gly Ile Ile Lys Gly Met Lys Val Glu Leu Ser Thr 
             100                105                110
Val Asn Val Arg Thr Thr Lys Pro Pro Lys Arg Arg Pro Leu Lys Ser 
         115                120                125
Leu Glu Ala Thr Leu Gly Arg Leu Arg Arg Ala Thr Glu Tyr Ala Pro 
     130                135                140
Lys Lys Arg Ile Glu Pro Leu Ser Pro Glu Leu Val Ala Ala Ala Ser 
 145                150                155                160
Ala Val Ala Asp Ser Leu Pro Phe Asp Lys Gln Thr Thr Lys Ser Glu 
                 165                170                175
Leu Leu Ser Gln Leu Gln Gln His Glu Glu Glu Ser Arg Ala Gln Arg 
             180                185                190
Asp Ala Lys Arg Pro Lys Ile Ser Phe Ser Asn Ile Ile Ser Asp Met 
         195                200                205
Lys Val Ala Arg Ser Ala Thr Ala Arg Val Arg Ser Arg Pro Glu Leu 
     210                215                220
Arg Ile Gln Phe Asp Glu Gly Tyr Asp Asn Tyr Pro Gly Gln Glu Lys 
 225                230                235                240
Thr Asp Asp Leu Lys Lys Arg Lys Asn Ile Phe Thr Gly Lys Arg Leu 
                 245                250                255
Asn Ile Phe Asp Met Met Ala Val Thr Lys Glu Ala Pro Glu Thr Asp 
             260                265                270
Thr Ser Pro Ser Leu Trp Asn Val Glu Phe Ala Lys Gln Leu Ala Thr 
         275                280                285
Val Asn Glu Gln Pro Leu Gln Asn Gly Phe Glu Glu Leu Ile Gln Trp 
     290                295                300
Thr Lys Glu Gly Lys Leu Trp Glu Phe Pro Ile Asn Asn Glu Ala Gly 
 305                310                315                320
Phe Asp Asp Asp Gly Ser Glu Phe His Glu His Ile Phe Leu Glu Lys 
                 325                330                335
His Leu Glu Ser Phe Pro Lys Gln Gly Pro Ile Arg His Phe Met Glu 
             340                345                350
Leu Val Thr Cys Gly Leu Ser Lys Asn Pro Tyr Leu Ser Val Lys Gln 
         355                360                365
Lys Val Glu His Ile Glu Trp Phe Arg Asn Tyr Phe Asn Glu Lys Lys 
     370                375                380
Asp Ile Leu Lys Glu Ser Asn Ile Gln Phe Asn Ter 
 385                390                395



<210> 4414
<211> 610
<212> DNA
<213> Rattus norvegicus
<308> AA799656
<400> 4414

ttttcaaca  tttaaataa  aatttttcc  catgatgtt  agtgaatgt  attttcttt  60
agaatatct  ttttttcat  aaaataatt  ctgaaccac  ctatatgct  gaccttctg  120
ctaacgctc  gatatgggt  tttcgagag  ccacaggtc  ccagctcca  gaacaggcg  180
attggtcct  gcttgggga  atcctccag  tgcttctcc  aaaatatat  ctcatggaa  240
tctgagcca  catcgtcaa  acctgcttc  ttgttaact  ggaactccc  cagtttccc  300
tcctttgtc  actgtatca  ctcctcaaa  ccattccca  acggctgtt  gcttactgt  360
gctaattgc  tagcaaatt  tatctccca  agagaaggt  ctgcttctg  ttcaggtgc  420
tcgtcgtca  acgccttaa  atcaaaaat  gaaagtctt  tccccttga  caaacattt  480
ctccttctg  aatcagctg  cttctcctg  ctaagcgaa  tgtccactt  ttcgtcaaa  540
tgaatctgg  gctgtggtc  tgaactaac  ctcatcgaa  gggatttgg  aattttcat  600
ttcgatatta  610



<210> 4415
<211> 384
<212> PRT
<213> Rattus norvegicus
<308> CAA87087
<400> 4415

Met Leu His Arg Ile Pro Ala Phe Leu Arg Pro Arg Pro Phe Ser Gly 
  1               5                  10                  15
Leu Pro Leu Ser Cys Gly Asn Arg Asp Val Ser Val Ala Val Leu Pro 
             20                  25                  30
Ala Ala Gln Ser Gly Ala Val Arg Thr Glu Asn Asn Ile Gln Arg His 
         35                  40                  45
Phe Cys Thr Ser Arg Ser Ile Cys Ser Lys Lys Val Asp Gln Ser Val 
     50                  55                  60
Pro Ala Asn Glu Ile Ser Gln Lys Ala Ala Glu Ser Gln Gly Arg Gly 
 65                  70                  75                  80
Lys Glu Thr Leu Lys Lys Asp Leu Leu Asp Ile Ile Lys Asp Met Lys 
                 85                  90                  95
Val Asp Leu Ser Thr Ala Asn Val Lys Thr Pro Lys Pro Arg Gly Arg 
             100                105                110
Lys Pro Ser Ala Ser Leu Glu Ala Thr Val Asp Arg Leu Gln Lys Ala 
         115                120                125
Pro Glu Asp Pro Pro Lys Lys Arg Asn Glu Phe Leu Ser Pro Glu Leu 
     130                135                140
Val Ala Ala Ala Ser Ala Val Ala Asp Ser Leu Pro Phe Asp Lys Gln 
 145                150                155                160
Thr Thr Lys Ser Glu Leu Leu Arg Gln Leu Gln Gln His Glu Glu Glu 
                 165                170                175
Leu Arg Ala Gln Lys Asp Arg Glu Lys Arg Arg Ile Ser Phe Thr His 
             180                185                190
Ile Ile Ser Asn Met Lys Ile Ala Lys Ser Pro Ser Gly Arg Ala Ser 
         195                200                205
Thr Arg Pro Gln His Gln Ile Gln Phe Asp Glu Asp Met Asp Ser Ser 
     210                215                220
Leu Lys Gln Glu Lys Pro Thr Asp Phe Arg Lys Arg Lys Tyr Leu Phe 
 225                230                235                240
Lys Gly Lys Arg Leu Ser Ile Phe Ala Asp Lys Ala Phe Ala Asp Glu 
                 245                250                255
Pro Pro Glu Pro Glu Ala Ser Pro Ser Leu Trp Glu Ile Glu Phe Ala 
             260                265                270
Lys Gln Leu Ala Ser Val Ala Asp Gln Pro Phe Glu Asn Gly Phe Glu 
         275                280                285
Glu Met Ile Gln Trp Thr Lys Glu Gly Lys Leu Trp Glu Phe Pro Val 
     290                295                300
Asn Asn Glu Ala Gly Leu Asp Asp Asp Gly Ser Glu Phe His Glu His 
 305                310                315                320
Ile Phe Leu Asp Lys Tyr Leu Glu Asp Phe Pro Lys Gln Gly Pro Ile 
                 325                330                335
Arg Leu Phe Met Glu Leu Val Thr Cys Gly Leu Ser Lys Asn Pro Tyr 
             340                345                350
Leu Ser Val Lys Gln Lys Val Glu His Ile Glu Trp Phe Arg Asn Tyr 
         355                360                365
Phe Asn Glu Lys Arg Asp Ile Leu Lys Glu Asn Asn Ile Ala Phe Thr 
     370                375                380



<210> 4416
<211> 1202
<212> DNA
<213> Homo sapiens
<308> Z68747
<400> 4416

cggcgatgt  tcctagagt  tcgacgttc  tacctcttc  ccccctttc  cgccaccct  60
tgtcctctg  aagcccgga  acatcagcg  ctgcgatta  gctactcac  gttcggcac  120
gaacagtca  gtaccgcag  tcagcgctg  tggcccgga  aaaaaataa  atccaaaga  180
attttggca  taacagtgt  atctgtagc  agaaagata  gcagtctgt  cgaactgag  240
agacttcca  ggagacttc  gagagccaa  acagtgaaa  ggaaaatac  aaaaaagac  300
tgttaggca  tattaaggg  atgaaagtt  aattaagca  agtaaatgt  cgaacaaca  360
agcccccca  aagaagacc  cttaaaagt  tggaagcta  acttggcag  cttcgaaga  420
ctacagaat  tgctccaaa  aagagaatt  agcccctga  tcctgagtt  gtggcagct  480
catctgctg  ggcagattc  ctccctttt  ataagcaaa  aaccaagtc  gagctgctg  540
gccagctcc  gcagcatga  gaagagtca  gggcacaga  agatgcaaa  cgacctaaa  600
ttagtttca  taacataat  tcagatatg  aagttgcca  atctgctac  gctagagtt  660
gttcaagac  agagcttcg  attcagttt  atgaaggct  tgacaatta  cctggccag  720
agaagacgg  tgatcttaa  aaaaggaaa  atatattca  agggaaaag  cttaatatt  780
ttgacatga  ggcagttac  aaagaagca  ctgaaacag  cacatcacc  tcactttgg  840
atgtggaat  tgctaagca  ttagccaca  taaatgaac  accccttca  aatggattt  900
aagagctga  ccagtggac  aaagagggg  aactatggg  gttcccaat  aacaatgaa  960
caggttttg  tgatgatgg  tcagaattt  atgaacata  atttctgga  aaacacctg  1020
agagctttc  aaaacaagg  ccaattcgc  acttcatgg  gctggtgac  tgtggcctt  1080
ccaaaaacc  atatcttag  gttaaacag  aggttgaac  catagagtg  tttagaaat  1140
attttaatg  aaaaaagga  attctaaaa  aaagtaaca  acagttcaa  taagaccat  1200
ga  1202



<210> 4417
<211> 395
<212> PRT
<213> Homo sapiens
<308> CAA92951
<400> 4417

Met Phe Pro Arg Val Ser Thr Phe Leu Pro Leu Arg Pro Leu Ser Arg 
  1               5                  10                  15
His Pro Leu Ser Ser Gly Ser Pro Glu Thr Ser Ala Ala Ala Ile Met 
             20                  25                  30
Leu Leu Thr Val Arg His Gly Thr Val Arg Tyr Arg Ser Ser Ala Leu 
         35                  40                  45
Leu Ala Arg Thr Lys Asn Asn Ile Gln Arg Tyr Phe Gly Thr Asn Ser 
     50                  55                  60
Val Ile Cys Ser Lys Lys Asp Lys Gln Ser Val Arg Thr Glu Glu Thr 
 65                  70                  75                  80
Ser Lys Glu Thr Ser Glu Ser Gln Asp Ser Glu Lys Glu Asn Thr Lys 
                 85                  90                  95
Lys Asp Leu Leu Gly Ile Ile Lys Gly Met Lys Val Glu Leu Ser Thr 
             100                105                110
Val Asn Val Arg Thr Thr Lys Pro Pro Lys Arg Arg Pro Leu Lys Ser 
         115                120                125
Leu Glu Ala Thr Leu Gly Arg Leu Arg Arg Ala Thr Glu Tyr Ala Pro 
     130                135                140
Lys Lys Arg Ile Glu Pro Leu Ser Pro Glu Leu Val Ala Ala Ala Ser 
 145                150                155                160
Ala Val Ala Asp Ser Leu Pro Phe Asp Lys Gln Thr Thr Lys Ser Glu 
                 165                170                175
Leu Leu Ser Gln Leu Gln Gln His Glu Glu Glu Ser Arg Ala Gln Arg 
             180                185                190
Asp Ala Lys Arg Pro Lys Ile Ser Phe Ser Asn Ile Ile Ser Asp Met 
         195                200                205
Lys Val Ala Arg Ser Ala Thr Ala Arg Val Arg Ser Arg Pro Glu Leu 
     210                215                220
Arg Ile Gln Phe Asp Glu Gly Tyr Asp Asn Tyr Pro Gly Gln Glu Lys 
 225                230                235                240
Thr Asp Asp Leu Lys Lys Arg Lys Asn Ile Phe Thr Gly Lys Arg Leu 
                 245                250                255
Asn Ile Phe Asp Met Met Ala Val Thr Lys Glu Ala Pro Glu Thr Asp 
             260                265                270
Thr Ser Pro Ser Leu Trp Asn Val Glu Phe Ala Lys Gln Leu Ala Thr 
         275                280                285
Val Asn Glu Gln Pro Leu Gln Asn Gly Phe Glu Glu Leu Ile Gln Trp 
     290                295                300
Thr Lys Glu Gly Lys Leu Trp Glu Phe Pro Ile Asn Asn Glu Ala Gly 
 305                310                315                320
Phe Asp Asp Asp Gly Ser Glu Phe His Glu His Ile Phe Leu Glu Lys 
                 325                330                335
His Leu Glu Ser Phe Pro Lys Gln Gly Pro Ile Arg His Phe Met Glu 
             340                345                350
Leu Val Thr Cys Gly Leu Ser Lys Asn Pro Tyr Leu Ser Val Lys Gln 
         355                360                365
Lys Val Glu His Ile Glu Trp Phe Arg Asn Tyr Phe Asn Glu Lys Lys 
     370                375                380
Asp Ile Leu Lys Glu Ser Asn Ile Gln Phe Asn 
 385                390                395



<210> 4418
<211> 610
<212> DNA
<213> Rattus norvegicus
<308> AA799656
<400> 4418

ttttcaaca  tttaaataa  aatttttcc  catgatgtt  agtgaatgt  attttcttt  60
agaatatct  ttttttcat  aaaataatt  ctgaaccac  ctatatgct  gaccttctg  120
ctaacgctc  gatatgggt  tttcgagag  ccacaggtc  ccagctcca  gaacaggcg  180
attggtcct  gcttgggga  atcctccag  tgcttctcc  aaaatatat  ctcatggaa  240
tctgagcca  catcgtcaa  acctgcttc  ttgttaact  ggaactccc  cagtttccc  300
tcctttgtc  actgtatca  ctcctcaaa  ccattccca  acggctgtt  gcttactgt  360
gctaattgc  tagcaaatt  tatctccca  agagaaggt  ctgcttctg  ttcaggtgc  420
tcgtcgtca  acgccttaa  atcaaaaat  gaaagtctt  tccccttga  caaacattt  480
ctccttctg  aatcagctg  cttctcctg  ctaagcgaa  tgtccactt  ttcgtcaaa  540
tgaatctgg  gctgtggtc  tgaactaac  ctcatcgaa  gggatttgg  aattttcat  600
ttcgatatta  610



<210> 4419
<211> 1202
<212> DNA
<213> Homo sapiens
<308> Z68747
<400> 4419

cggcgatgt  tcctagagt  tcgacgttc  tacctcttc  ccccctttc  cgccaccct  60
tgtcctctg  aagcccgga  acatcagcg  ctgcgatta  gctactcac  gttcggcac  120
gaacagtca  gtaccgcag  tcagcgctg  tggcccgga  aaaaaataa  atccaaaga  180
attttggca  taacagtgt  atctgtagc  agaaagata  gcagtctgt  cgaactgag  240
agacttcca  ggagacttc  gagagccaa  acagtgaaa  ggaaaatac  aaaaaagac  300
tgttaggca  tattaaggg  atgaaagtt  aattaagca  agtaaatgt  cgaacaaca  360
agcccccca  aagaagacc  cttaaaagt  tggaagcta  acttggcag  cttcgaaga  420
ctacagaat  tgctccaaa  aagagaatt  agcccctga  tcctgagtt  gtggcagct  480
catctgctg  ggcagattc  ctccctttt  ataagcaaa  aaccaagtc  gagctgctg  540
gccagctcc  gcagcatga  gaagagtca  gggcacaga  agatgcaaa  cgacctaaa  600
ttagtttca  taacataat  tcagatatg  aagttgcca  atctgctac  gctagagtt  660
gttcaagac  agagcttcg  attcagttt  atgaaggct  tgacaatta  cctggccag  720
agaagacgg  tgatcttaa  aaaaggaaa  atatattca  agggaaaag  cttaatatt  780
ttgacatga  ggcagttac  aaagaagca  ctgaaacag  cacatcacc  tcactttgg  840
atgtggaat  tgctaagca  ttagccaca  taaatgaac  accccttca  aatggattt  900
aagagctga  ccagtggac  aaagagggg  aactatggg  gttcccaat  aacaatgaa  960
caggttttg  tgatgatgg  tcagaattt  atgaacata  atttctgga  aaacacctg  1020
agagctttc  aaaacaagg  ccaattcgc  acttcatgg  gctggtgac  tgtggcctt  1080
ccaaaaacc  atatcttag  gttaaacag  aggttgaac  catagagtg  tttagaaat  1140
attttaatg  aaaaaagga  attctaaaa  aaagtaaca  acagttcaa  taagaccat  1200
ga  1202



<210> 4420
<211> 396
<212> PRT
<213> Homo sapiens
<308> Z68747
<400> 4420

Met Phe Pro Arg Val Ser Thr Phe Leu Pro Leu Arg Pro Leu Ser Arg 
  1               5                  10                  15
His Pro Leu Ser Ser Gly Ser Pro Glu Thr Ser Ala Ala Ala Ile Met 
             20                  25                  30
Leu Leu Thr Val Arg His Gly Thr Val Arg Tyr Arg Ser Ser Ala Leu 
         35                  40                  45
Leu Ala Arg Thr Lys Asn Asn Ile Gln Arg Tyr Phe Gly Thr Asn Ser 
     50                  55                  60
Val Ile Cys Ser Lys Lys Asp Lys Gln Ser Val Arg Thr Glu Glu Thr 
 65                  70                  75                  80
Ser Lys Glu Thr Ser Glu Ser Gln Asp Ser Glu Lys Glu Asn Thr Lys 
                 85                  90                  95
Lys Asp Leu Leu Gly Ile Ile Lys Gly Met Lys Val Glu Leu Ser Thr 
             100                105                110
Val Asn Val Arg Thr Thr Lys Pro Pro Lys Arg Arg Pro Leu Lys Ser 
         115                120                125
Leu Glu Ala Thr Leu Gly Arg Leu Arg Arg Ala Thr Glu Tyr Ala Pro 
     130                135                140
Lys Lys Arg Ile Glu Pro Leu Ser Pro Glu Leu Val Ala Ala Ala Ser 
 145                150                155                160
Ala Val Ala Asp Ser Leu Pro Phe Asp Lys Gln Thr Thr Lys Ser Glu 
                 165                170                175
Leu Leu Ser Gln Leu Gln Gln His Glu Glu Glu Ser Arg Ala Gln Arg 
             180                185                190
Asp Ala Lys Arg Pro Lys Ile Ser Phe Ser Asn Ile Ile Ser Asp Met 
         195                200                205
Lys Val Ala Arg Ser Ala Thr Ala Arg Val Arg Ser Arg Pro Glu Leu 
     210                215                220
Arg Ile Gln Phe Asp Glu Gly Tyr Asp Asn Tyr Pro Gly Gln Glu Lys 
 225                230                235                240
Thr Asp Asp Leu Lys Lys Arg Lys Asn Ile Phe Thr Gly Lys Arg Leu 
                 245                250                255
Asn Ile Phe Asp Met Met Ala Val Thr Lys Glu Ala Pro Glu Thr Asp 
             260                265                270
Thr Ser Pro Ser Leu Trp Asn Val Glu Phe Ala Lys Gln Leu Ala Thr 
         275                280                285
Val Asn Glu Gln Pro Leu Gln Asn Gly Phe Glu Glu Leu Ile Gln Trp 
     290                295                300
Thr Lys Glu Gly Lys Leu Trp Glu Phe Pro Ile Asn Asn Glu Ala Gly 
 305                310                315                320
Phe Asp Asp Asp Gly Ser Glu Phe His Glu His Ile Phe Leu Glu Lys 
                 325                330                335
His Leu Glu Ser Phe Pro Lys Gln Gly Pro Ile Arg His Phe Met Glu 
             340                345                350
Leu Val Thr Cys Gly Leu Ser Lys Asn Pro Tyr Leu Ser Val Lys Gln 
         355                360                365
Lys Val Glu His Ile Glu Trp Phe Arg Asn Tyr Phe Asn Glu Lys Lys 
     370                375                380
Asp Ile Leu Lys Glu Ser Asn Ile Gln Phe Asn Ter 
 385                390                395



<210> 4421
<211> 610
<212> DNA
<213> Rattus norvegicus
<308> AA799656
<400> 4421

ttttcaaca  tttaaataa  aatttttcc  catgatgtt  agtgaatgt  attttcttt  60
agaatatct  ttttttcat  aaaataatt  ctgaaccac  ctatatgct  gaccttctg  120
ctaacgctc  gatatgggt  tttcgagag  ccacaggtc  ccagctcca  gaacaggcg  180
attggtcct  gcttgggga  atcctccag  tgcttctcc  aaaatatat  ctcatggaa  240
tctgagcca  catcgtcaa  acctgcttc  ttgttaact  ggaactccc  cagtttccc  300
tcctttgtc  actgtatca  ctcctcaaa  ccattccca  acggctgtt  gcttactgt  360
gctaattgc  tagcaaatt  tatctccca  agagaaggt  ctgcttctg  ttcaggtgc  420
tcgtcgtca  acgccttaa  atcaaaaat  gaaagtctt  tccccttga  caaacattt  480
ctccttctg  aatcagctg  cttctcctg  ctaagcgaa  tgtccactt  ttcgtcaaa  540
tgaatctgg  gctgtggtc  tgaactaac  ctcatcgaa  gggatttgg  aattttcat  600
ttcgatatta  610



<210> 4422
<211> 384
<212> PRT
<213> Rattus norvegicus
<308> CAA87087
<400> 4422

Met Leu His Arg Ile Pro Ala Phe Leu Arg Pro Arg Pro Phe Ser Gly 
  1               5                  10                  15
Leu Pro Leu Ser Cys Gly Asn Arg Asp Val Ser Val Ala Val Leu Pro 
             20                  25                  30
Ala Ala Gln Ser Gly Ala Val Arg Thr Glu Asn Asn Ile Gln Arg His 
         35                  40                  45
Phe Cys Thr Ser Arg Ser Ile Cys Ser Lys Lys Val Asp Gln Ser Val 
     50                  55                  60
Pro Ala Asn Glu Ile Ser Gln Lys Ala Ala Glu Ser Gln Gly Arg Gly 
 65                  70                  75                  80
Lys Glu Thr Leu Lys Lys Asp Leu Leu Asp Ile Ile Lys Asp Met Lys 
                 85                  90                  95
Val Asp Leu Ser Thr Ala Asn Val Lys Thr Pro Lys Pro Arg Gly Arg 
             100                105                110
Lys Pro Ser Ala Ser Leu Glu Ala Thr Val Asp Arg Leu Gln Lys Ala 
         115                120                125
Pro Glu Asp Pro Pro Lys Lys Arg Asn Glu Phe Leu Ser Pro Glu Leu 
     130                135                140
Val Ala Ala Ala Ser Ala Val Ala Asp Ser Leu Pro Phe Asp Lys Gln 
 145                150                155                160
Thr Thr Lys Ser Glu Leu Leu Arg Gln Leu Gln Gln His Glu Glu Glu 
                 165                170                175
Leu Arg Ala Gln Lys Asp Arg Glu Lys Arg Arg Ile Ser Phe Thr His 
             180                185                190
Ile Ile Ser Asn Met Lys Ile Ala Lys Ser Pro Ser Gly Arg Ala Ser 
         195                200                205
Thr Arg Pro Gln His Gln Ile Gln Phe Asp Glu Asp Met Asp Ser Ser 
     210                215                220
Leu Lys Gln Glu Lys Pro Thr Asp Phe Arg Lys Arg Lys Tyr Leu Phe 
 225                230                235                240
Lys Gly Lys Arg Leu Ser Ile Phe Ala Asp Lys Ala Phe Ala Asp Glu 
                 245                250                255
Pro Pro Glu Pro Glu Ala Ser Pro Ser Leu Trp Glu Ile Glu Phe Ala 
             260                265                270
Lys Gln Leu Ala Ser Val Ala Asp Gln Pro Phe Glu Asn Gly Phe Glu 
         275                280                285
Glu Met Ile Gln Trp Thr Lys Glu Gly Lys Leu Trp Glu Phe Pro Val 
     290                295                300
Asn Asn Glu Ala Gly Leu Asp Asp Asp Gly Ser Glu Phe His Glu His 
 305                310                315                320
Ile Phe Leu Asp Lys Tyr Leu Glu Asp Phe Pro Lys Gln Gly Pro Ile 
                 325                330                335
Arg Leu Phe Met Glu Leu Val Thr Cys Gly Leu Ser Lys Asn Pro Tyr 
             340                345                350
Leu Ser Val Lys Gln Lys Val Glu His Ile Glu Trp Phe Arg Asn Tyr 
         355                360                365
Phe Asn Glu Lys Arg Asp Ile Leu Lys Glu Asn Asn Ile Ala Phe Thr 
     370                375                380



<210> 4423
<211> 1202
<212> DNA
<213> Homo sapiens
<308> Z68747
<400> 4423

cggcgatgt  tcctagagt  tcgacgttc  tacctcttc  ccccctttc  cgccaccct  60
tgtcctctg  aagcccgga  acatcagcg  ctgcgatta  gctactcac  gttcggcac  120
gaacagtca  gtaccgcag  tcagcgctg  tggcccgga  aaaaaataa  atccaaaga  180
attttggca  taacagtgt  atctgtagc  agaaagata  gcagtctgt  cgaactgag  240
agacttcca  ggagacttc  gagagccaa  acagtgaaa  ggaaaatac  aaaaaagac  300
tgttaggca  tattaaggg  atgaaagtt  aattaagca  agtaaatgt  cgaacaaca  360
agcccccca  aagaagacc  cttaaaagt  tggaagcta  acttggcag  cttcgaaga  420
ctacagaat  tgctccaaa  aagagaatt  agcccctga  tcctgagtt  gtggcagct  480
catctgctg  ggcagattc  ctccctttt  ataagcaaa  aaccaagtc  gagctgctg  540
gccagctcc  gcagcatga  gaagagtca  gggcacaga  agatgcaaa  cgacctaaa  600
ttagtttca  taacataat  tcagatatg  aagttgcca  atctgctac  gctagagtt  660
gttcaagac  agagcttcg  attcagttt  atgaaggct  tgacaatta  cctggccag  720
agaagacgg  tgatcttaa  aaaaggaaa  atatattca  agggaaaag  cttaatatt  780
ttgacatga  ggcagttac  aaagaagca  ctgaaacag  cacatcacc  tcactttgg  840
atgtggaat  tgctaagca  ttagccaca  taaatgaac  accccttca  aatggattt  900
aagagctga  ccagtggac  aaagagggg  aactatggg  gttcccaat  aacaatgaa  960
caggttttg  tgatgatgg  tcagaattt  atgaacata  atttctgga  aaacacctg  1020
agagctttc  aaaacaagg  ccaattcgc  acttcatgg  gctggtgac  tgtggcctt  1080
ccaaaaacc  atatcttag  gttaaacag  aggttgaac  catagagtg  tttagaaat  1140
attttaatg  aaaaaagga  attctaaaa  aaagtaaca  acagttcaa  taagaccat  1200
ga  1202



<210> 4424
<211> 395
<212> PRT
<213> Homo sapiens
<308> CAA92951
<400> 4424

Met Phe Pro Arg Val Ser Thr Phe Leu Pro Leu Arg Pro Leu Ser Arg 
  1               5                  10                  15
His Pro Leu Ser Ser Gly Ser Pro Glu Thr Ser Ala Ala Ala Ile Met 
             20                  25                  30
Leu Leu Thr Val Arg His Gly Thr Val Arg Tyr Arg Ser Ser Ala Leu 
         35                  40                  45
Leu Ala Arg Thr Lys Asn Asn Ile Gln Arg Tyr Phe Gly Thr Asn Ser 
     50                  55                  60
Val Ile Cys Ser Lys Lys Asp Lys Gln Ser Val Arg Thr Glu Glu Thr 
 65                  70                  75                  80
Ser Lys Glu Thr Ser Glu Ser Gln Asp Ser Glu Lys Glu Asn Thr Lys 
                 85                  90                  95
Lys Asp Leu Leu Gly Ile Ile Lys Gly Met Lys Val Glu Leu Ser Thr 
             100                105                110
Val Asn Val Arg Thr Thr Lys Pro Pro Lys Arg Arg Pro Leu Lys Ser 
         115                120                125
Leu Glu Ala Thr Leu Gly Arg Leu Arg Arg Ala Thr Glu Tyr Ala Pro 
     130                135                140
Lys Lys Arg Ile Glu Pro Leu Ser Pro Glu Leu Val Ala Ala Ala Ser 
 145                150                155                160
Ala Val Ala Asp Ser Leu Pro Phe Asp Lys Gln Thr Thr Lys Ser Glu 
                 165                170                175
Leu Leu Ser Gln Leu Gln Gln His Glu Glu Glu Ser Arg Ala Gln Arg 
             180                185                190
Asp Ala Lys Arg Pro Lys Ile Ser Phe Ser Asn Ile Ile Ser Asp Met 
         195                200                205
Lys Val Ala Arg Ser Ala Thr Ala Arg Val Arg Ser Arg Pro Glu Leu 
     210                215                220
Arg Ile Gln Phe Asp Glu Gly Tyr Asp Asn Tyr Pro Gly Gln Glu Lys 
 225                230                235                240
Thr Asp Asp Leu Lys Lys Arg Lys Asn Ile Phe Thr Gly Lys Arg Leu 
                 245                250                255
Asn Ile Phe Asp Met Met Ala Val Thr Lys Glu Ala Pro Glu Thr Asp 
             260                265                270
Thr Ser Pro Ser Leu Trp Asn Val Glu Phe Ala Lys Gln Leu Ala Thr 
         275                280                285
Val Asn Glu Gln Pro Leu Gln Asn Gly Phe Glu Glu Leu Ile Gln Trp 
     290                295                300
Thr Lys Glu Gly Lys Leu Trp Glu Phe Pro Ile Asn Asn Glu Ala Gly 
 305                310                315                320
Phe Asp Asp Asp Gly Ser Glu Phe His Glu His Ile Phe Leu Glu Lys 
                 325                330                335
His Leu Glu Ser Phe Pro Lys Gln Gly Pro Ile Arg His Phe Met Glu 
             340                345                350
Leu Val Thr Cys Gly Leu Ser Lys Asn Pro Tyr Leu Ser Val Lys Gln 
         355                360                365
Lys Val Glu His Ile Glu Trp Phe Arg Asn Tyr Phe Asn Glu Lys Lys 
     370                375                380
Asp Ile Leu Lys Glu Ser Asn Ile Gln Phe Asn 
 385                390                395



<210> 4425
<211> 502
<212> DNA
<213> Rattus norvegicus
<308> AA799657
<400> 4425

gctgggcaa  cgaccttta  ttataaagg  aacagtttc  gcgtcatta  aaacagtaa  60
ccacatggt  tgaaggcac  tggttgggg  gatgggggc  tcacacagg  cccaaggct  120
ctgggagaa  tggaggctg  tgggaagaa  ggggacttc  aggtgagag  aagaaagga  180
tcagagaga  atgaagggg  gggtagcct  ccaggctca  ctgggatag  gcagtggct  240
gctgccagt  ggaggcact  agaaccaga  ctgatttgg  aagtgtgtg  gttgggggt  300
gggtgggag  tcctgcccc  aaatgtccc  agcccaacc  caccccaat  cttaaggca  360
cttcataat  ttcagtctg  ggctgccct  ccttgagcc  cccttgagc  gagaatttc  420
ggtgcaggc  gaacctctg  agaatagcc  catattact  agatggatc  ggcaggtct  480
ggtggcaag  atgctggcg  tg  502



<210> 4426
<211> 2620
<212> DNA
<213> Homo sapiens
<308> NM_006663
<400> 4426

gcggccgcg  cgacaaaca  gtgagtctc  gctggagtg  agtggtgca  tggtgcaat  60
tcggctcac  gcaacctcc  cctcctggg  tcaagcgat  cctgtgcct  ggccttccg  120
gtagctggg  ttgcaggcg  gtgccacca  gcccggcta  ttttttttt  ttttttttt  180
tttttgtat  tttagtaga  acagggttc  taccatgtt  gccaggctg  tctcaaact  240
ctgatctca  gagatgtgg  ctgcctccg  cctcccaaa  ttctgggat  acagggtgt  300
gagccactc  gactcagcc  ataatgcat  tttttattt  cacctgctt  actgtcaga  360
tgagtaaga  agagaagaa  tcattaaac  ccaggattc  acttgcctg  tggagtttt  420
tgcctgaga  gttaggaga  gaaactctc  ggatctcag  aaatcacat  tatcacggt  480
ggtagaagt  gattctaga  tcagccaga  tgagttcaa  tcccaactg  atggctttg  540
gcaactgac  gtcctctct  aggcccaga  tccctttcg  taatgtgga  atggcagtg  600
atctacctc  caaagcagt  gtgagatta  aataaggta  gcatgtaaa  cgccaggca  660
atactaact  ctcaataaa  gggaggcat  ataattgta  attattcac  gcccaagga  720
agtgtagcc  agagagggc  aggaacttg  ccctgaggt  aacacagaa  atcatgtgc  780
ggttgtatg  cctggaagt  gtggagagg  agtgttggg  gtcttcctg  ggacctgtc  840
tctgatggg  tcttgttcc  gctaggacc  cccaaaccc  ccaccgagc  ggagcctga  900
ccggagata  aggggctgc  gacaccagt  ctggaggct  gcgatgtgg  tgaaggacc  960
tgtagcaag  cctctcagc  ccacgaggc  gcagccagc  ctgccaccg  aggcacagt  1020
ggtgcccga  ctggaggag  tggcacggg  gttggcgga  attccccgg  ccctcaaac  1080
caggggctc  atggagcag  cccctgctg  ggccctgcc  cctacccac  agaaacagt  1140
ccagcagat  atcagccgc  tcttccatc  tcatggggg  ccagggccc  gggggcgga  1200
ccagagctg  cccccatca  tgagggatc  gaggccagg  cagggcccc  tgctcctgc  1260
ccaccagct  ccattccac  gcccggccc  gtcccagag  agcccacca  agcagccgc  1320
gagcatgga  atgcgctct  tgctgcgga  ggcgggctc  ccgcgcaag  cccgccgcg  1380
gcgcctcaa  cctctggtg  tcctcctgg  cgcggcgct  accggggag  tggaggtgg  1440
gcagcaggc  gtgaaggag  tgaacgacc  gagccagcc  aacgaggag  gcatcactg  1500
cttgcacaa  gccatctgc  gcgccaact  ctctatcgt  gatttcctc  tcaccgcgg  1560
tgccaatgt  aactccccc  acagccacg  ctggacacc  ttgcactgc  cggcgtcgt  1620
caacgacac  gtcatctgc  tggcgctgg  gcagcacgg  gctgcaatc  tcgccacca  1680
gctcagcga  ggcgccacc  ccttcgaga  gtgcgaccc  taccgcgag  gttatgctg  1740
ctgcgccac  tacctggca  acgtcgagc  gagtatggg  ctgatgaac  gcggggcag  1800
gtacgctct  tgggactac  gcgccgagt  cggggacga  ctgtccttc  gcgagggcg  1860
gtcggtcac  gtgctgcgg  gggacgggc  ggaggagac  gactggtgg  gggccgcgc  1920
gcacggcca  gagggctac  tgccgcgga  ctacttcgg  ctgttcccc  gggtgaagc  1980
tcaaaggag  aaagtctag  aggatagaa  gaggtttct  aggctgaca  aaacaagca  2040
tcctgcctt  cctccagac  tctccctct  ttttttgct  cctttatct  cacccctca  2100
cctgctggt  gtggtcctt  ccaccggtt  tctgttctc  tggaagtcc  gggaagaag  2160
agggcccca  ccttaaatt  agtaatctg  cttagcctt  ggaggtctg  gaagggctg  2220
aaatcactg  ggacaggaa  ccacttcct  ttgccaaat  agatcccgt  caaagtgcc  2280
cccatgcct  ccaccatca  cacatcccc  agcaagcca  ccacctgcc  agccgggcc  2340
gggatgggc  accacacca  tggatattc  tgggagtca  tgctgacac  atctctccc  2400
gcagtcttg  ggtctgggt  ggaaacatt  gtctctacc  ggatccctg  cccacctct  2460
cccaattaa  tgccttcac  cagcactgg  ttaatgttt  taaacaaaa  agagaaact  2520
tccttataa  taaaagtag  ttgcacaga  aaaaaaaaa  cacaacctt  ggccgcccc  2580
ccaagctct  tctccaaaa  aaaaaaaaa  aaaaaaaaaa  2620



<210> 4427
<211> 478
<212> DNA
<213> Rattus norvegicus
<308> AA799663
<400> 4427

ccagcctca  agttttatt  tcaactgtg  acattcgag  tcacatccc  tggtgtaca  60
cttataaca  ggacagtga  agacggcag  ggctgcgtg  gccatttgg  gaaatggtc  120
tgctcagaa  ccacagtcc  gggcaagca  gggcctaag  gatcccagg  tccacacct  180
agcattgag  aaatgcaca  agagtcctt  tgcatacgg  actactgaa  gcaaacaaa  240
acagggtct  cagtttctg  tgccatagg  ggcagagcg  acacacaca  ctgcatact  300
gctcagtat  ggctgaata  actcctggc  ctggtcctc  atggctggg  ctggcagct  360
tgcctcctc  ttgttgagg  cttctagga  ctgggtgac  agaatgtcc  tagggagtg  420
ctcgctccg  tccactgct  ccgtgaaga  ttgcttgcc  aagcacagc  tcttccag  478



<210> 4428
<211> 276
<212> PRT
<213> Rattus norvegicus
<308> CAA52612
<400> 4428

Met Cys Ile Ile Phe Phe Lys Phe Asp Pro Arg Pro Val Ser Lys Asn 
  1               5                  10                  15
Ala Tyr Arg Leu Ile Leu Ala Ala Asn Arg Asp Glu Phe Tyr Asn Arg 
             20                  25                  30
Pro Ser Lys Leu Ala Asp Phe Trp Gly Asn Asn Ser Glu Ile Leu Ser 
         35                  40                  45
Gly Leu Asp Met Glu Glu Gly Lys Ala Gly Gly Thr Trp Leu Gly Ile 
     50                  55                  60
Ser Thr Arg Gly Lys Leu Gly Ala Leu Thr Asn Tyr Leu Gln Pro Arg 
 65                  70                  75                  80
Gln Glu Pro Asp Ala Arg Gly Arg Gly Glu Leu Val Ser His Phe Leu 
                 85                  90                  95
Thr Ser Asp Met Asp Ser Leu Ser Tyr Leu Lys Lys Val Ser Thr Glu 
             100                105                110
Gly His Leu Tyr Asn Gly Phe Asn Ile Ile Ala Ala Asp Leu Ser Thr 
         115                120                125
Ser Lys Gly Asp Val Val Cys Tyr Tyr Gly Asn Arg Gly Glu Pro Glu 
     130                135                140
Pro Ile Val Leu Thr Pro Gly Thr Tyr Gly Leu Ser Asn Ala Leu Leu 
 145                150                155                160
Glu Thr Pro Trp Lys Lys Leu Cys Phe Gly Lys Gln Leu Phe Met Glu 
                 165                170                175
Ala Val Glu Gln Ser Glu Ala Leu Pro Lys Asp Val Leu Val Thr Gln 
             180                185                190
Leu Leu Asp Val Leu Asn Asn Glu Glu Ala Gln Leu Pro Asp Pro Ala 
         195                200                205
Ile Glu Asp Gln Gly Gln Glu Tyr Val Gln Pro Ile Leu Asn Lys Tyr 
     210                215                220
Ala Ala Val Trp Cys Arg Cys Ala Ser Tyr Gly Thr Arg Thr Asn Thr 
 225                230                235                240
Ile Ile Leu Val Asp Ala Asn Gly His Val Thr Phe Thr Glu Arg Ser 
                 245                250                255
Met Leu Asp Lys Asp Thr Ser Arg Trp Glu Thr Asn Thr Tyr Glu Phe 
             260                265                270
Thr Leu Gln Ser 
         275



<210> 4429
<211> 661
<212> DNA
<213> Homo sapiens
<308> BG699621
<400> 4429

agcggagtc  gcggcggtg  cggaggcga  ctcgcgacc  gtgtcagca  agccgccct  60
caccaccat  tgcatcatc  tctttaagt  gatcctagc  ctgtttcca  aaacgcgta  120
aggtaaccc  ctcgctctg  atctgctgc  ccctgcagg  tcctgggtg  ccagccagt  180
ctcatgcca  ccaagctgc  gtgtgcagg  aggtgtgtg  gccaggacg  ggctgcaca  240
gcctggcac  gccctccag  acagggtca  tcagtgtgg  atgctgtca  aatgcctct  300
ggggcgggg  ctccagtca  tgtacaaag  cgtgaagac  cagccacag  aggcagcca  360
aggctcatc  tggcagcca  cagggatga  ttctacagc  gaccctcca  gttagctga  420
ttctggggg  acaacaacg  gatcctcag  gggctggac  tggaggaag  caaggaagg  480
ggcacatgg  tgggcatca  cacacgtgg  aagctggca  cactcacca  ctacctgca  540
ccgcagctg  actggcagg  ccgagggcg  gcacctacg  gctgagcaa  gcgctgctg  600
agactccct  gaggaagct  tgctttggg  agcagctct  cctggaggc  gtggaacgg  660
g  661



<210> 4430
<211> 478
<212> DNA
<213> Rattus norvegicus
<308> AA799663
<400> 4430

ccagcctca  agttttatt  tcaactgtg  acattcgag  tcacatccc  tggtgtaca  60
cttataaca  ggacagtga  agacggcag  ggctgcgtg  gccatttgg  gaaatggtc  120
tgctcagaa  ccacagtcc  gggcaagca  gggcctaag  gatcccagg  tccacacct  180
agcattgag  aaatgcaca  agagtcctt  tgcatacgg  actactgaa  gcaaacaaa  240
acagggtct  cagtttctg  tgccatagg  ggcagagcg  acacacaca  ctgcatact  300
gctcagtat  ggctgaata  actcctggc  ctggtcctc  atggctggg  ctggcagct  360
tgcctcctc  ttgttgagg  cttctagga  ctgggtgac  agaatgtcc  tagggagtg  420
ctcgctccg  tccactgct  ccgtgaaga  ttgcttgcc  aagcacagc  tcttccag  478



<210> 4431
<211> 276
<212> PRT
<213> Rattus norvegicus
<308> CAA52612
<400> 4431

Met Cys Ile Ile Phe Phe Lys Phe Asp Pro Arg Pro Val Ser Lys Asn 
  1               5                  10                  15
Ala Tyr Arg Leu Ile Leu Ala Ala Asn Arg Asp Glu Phe Tyr Asn Arg 
             20                  25                  30
Pro Ser Lys Leu Ala Asp Phe Trp Gly Asn Asn Ser Glu Ile Leu Ser 
         35                  40                  45
Gly Leu Asp Met Glu Glu Gly Lys Ala Gly Gly Thr Trp Leu Gly Ile 
     50                  55                  60
Ser Thr Arg Gly Lys Leu Gly Ala Leu Thr Asn Tyr Leu Gln Pro Arg 
 65                  70                  75                  80
Gln Glu Pro Asp Ala Arg Gly Arg Gly Glu Leu Val Ser His Phe Leu 
                 85                  90                  95
Thr Ser Asp Met Asp Ser Leu Ser Tyr Leu Lys Lys Val Ser Thr Glu 
             100                105                110
Gly His Leu Tyr Asn Gly Phe Asn Ile Ile Ala Ala Asp Leu Ser Thr 
         115                120                125
Ser Lys Gly Asp Val Val Cys Tyr Tyr Gly Asn Arg Gly Glu Pro Glu 
     130                135                140
Pro Ile Val Leu Thr Pro Gly Thr Tyr Gly Leu Ser Asn Ala Leu Leu 
 145                150                155                160
Glu Thr Pro Trp Lys Lys Leu Cys Phe Gly Lys Gln Leu Phe Met Glu 
                 165                170                175
Ala Val Glu Gln Ser Glu Ala Leu Pro Lys Asp Val Leu Val Thr Gln 
             180                185                190
Leu Leu Asp Val Leu Asn Asn Glu Glu Ala Gln Leu Pro Asp Pro Ala 
         195                200                205
Ile Glu Asp Gln Gly Gln Glu Tyr Val Gln Pro Ile Leu Asn Lys Tyr 
     210                215                220
Ala Ala Val Trp Cys Arg Cys Ala Ser Tyr Gly Thr Arg Thr Asn Thr 
 225                230                235                240
Ile Ile Leu Val Asp Ala Asn Gly His Val Thr Phe Thr Glu Arg Ser 
                 245                250                255
Met Leu Asp Lys Asp Thr Ser Arg Trp Glu Thr Asn Thr Tyr Glu Phe 
             260                265                270
Thr Leu Gln Ser 
         275



<210> 4432
<211> 661
<212> DNA
<213> Homo sapiens
<308> BG699621
<400> 4432

agcggagtc  gcggcggtg  cggaggcga  ctcgcgacc  gtgtcagca  agccgccct  60
caccaccat  tgcatcatc  tctttaagt  gatcctagc  ctgtttcca  aaacgcgta  120
aggtaaccc  ctcgctctg  atctgctgc  ccctgcagg  tcctgggtg  ccagccagt  180
ctcatgcca  ccaagctgc  gtgtgcagg  aggtgtgtg  gccaggacg  ggctgcaca  240
gcctggcac  gccctccag  acagggtca  tcagtgtgg  atgctgtca  aatgcctct  300
ggggcgggg  ctccagtca  tgtacaaag  cgtgaagac  cagccacag  aggcagcca  360
aggctcatc  tggcagcca  cagggatga  ttctacagc  gaccctcca  gttagctga  420
ttctggggg  acaacaacg  gatcctcag  gggctggac  tggaggaag  caaggaagg  480
ggcacatgg  tgggcatca  cacacgtgg  aagctggca  cactcacca  ctacctgca  540
ccgcagctg  actggcagg  ccgagggcg  gcacctacg  gctgagcaa  gcgctgctg  600
agactccct  gaggaagct  tgctttggg  agcagctct  cctggaggc  gtggaacgg  660
g  661



<210> 4433
<211> 478
<212> DNA
<213> Rattus norvegicus
<308> AA799663
<400> 4433

ccagcctca  agttttatt  tcaactgtg  acattcgag  tcacatccc  tggtgtaca  60
cttataaca  ggacagtga  agacggcag  ggctgcgtg  gccatttgg  gaaatggtc  120
tgctcagaa  ccacagtcc  gggcaagca  gggcctaag  gatcccagg  tccacacct  180
agcattgag  aaatgcaca  agagtcctt  tgcatacgg  actactgaa  gcaaacaaa  240
acagggtct  cagtttctg  tgccatagg  ggcagagcg  acacacaca  ctgcatact  300
gctcagtat  ggctgaata  actcctggc  ctggtcctc  atggctggg  ctggcagct  360
tgcctcctc  ttgttgagg  cttctagga  ctgggtgac  agaatgtcc  tagggagtg  420
ctcgctccg  tccactgct  ccgtgaaga  ttgcttgcc  aagcacagc  tcttccag  478



<210> 4434
<211> 276
<212> PRT
<213> Rattus norvegicus
<308> CAA52612
<400> 4434

Met Cys Ile Ile Phe Phe Lys Phe Asp Pro Arg Pro Val Ser Lys Asn 
  1               5                  10                  15
Ala Tyr Arg Leu Ile Leu Ala Ala Asn Arg Asp Glu Phe Tyr Asn Arg 
             20                  25                  30
Pro Ser Lys Leu Ala Asp Phe Trp Gly Asn Asn Ser Glu Ile Leu Ser 
         35                  40                  45
Gly Leu Asp Met Glu Glu Gly Lys Ala Gly Gly Thr Trp Leu Gly Ile 
     50                  55                  60
Ser Thr Arg Gly Lys Leu Gly Ala Leu Thr Asn Tyr Leu Gln Pro Arg 
 65                  70                  75                  80
Gln Glu Pro Asp Ala Arg Gly Arg Gly Glu Leu Val Ser His Phe Leu 
                 85                  90                  95
Thr Ser Asp Met Asp Ser Leu Ser Tyr Leu Lys Lys Val Ser Thr Glu 
             100                105                110
Gly His Leu Tyr Asn Gly Phe Asn Ile Ile Ala Ala Asp Leu Ser Thr 
         115                120                125
Ser Lys Gly Asp Val Val Cys Tyr Tyr Gly Asn Arg Gly Glu Pro Glu 
     130                135                140
Pro Ile Val Leu Thr Pro Gly Thr Tyr Gly Leu Ser Asn Ala Leu Leu 
 145                150                155                160
Glu Thr Pro Trp Lys Lys Leu Cys Phe Gly Lys Gln Leu Phe Met Glu 
                 165                170                175
Ala Val Glu Gln Ser Glu Ala Leu Pro Lys Asp Val Leu Val Thr Gln 
             180                185                190
Leu Leu Asp Val Leu Asn Asn Glu Glu Ala Gln Leu Pro Asp Pro Ala 
         195                200                205
Ile Glu Asp Gln Gly Gln Glu Tyr Val Gln Pro Ile Leu Asn Lys Tyr 
     210                215                220
Ala Ala Val Trp Cys Arg Cys Ala Ser Tyr Gly Thr Arg Thr Asn Thr 
 225                230                235                240
Ile Ile Leu Val Asp Ala Asn Gly His Val Thr Phe Thr Glu Arg Ser 
                 245                250                255
Met Leu Asp Lys Asp Thr Ser Arg Trp Glu Thr Asn Thr Tyr Glu Phe 
             260                265                270
Thr Leu Gln Ser 
         275



<210> 4435
<211> 661
<212> DNA
<213> Homo sapiens
<308> BG699621
<400> 4435

agcggagtc  gcggcggtg  cggaggcga  ctcgcgacc  gtgtcagca  agccgccct  60
caccaccat  tgcatcatc  tctttaagt  gatcctagc  ctgtttcca  aaacgcgta  120
aggtaaccc  ctcgctctg  atctgctgc  ccctgcagg  tcctgggtg  ccagccagt  180
ctcatgcca  ccaagctgc  gtgtgcagg  aggtgtgtg  gccaggacg  ggctgcaca  240
gcctggcac  gccctccag  acagggtca  tcagtgtgg  atgctgtca  aatgcctct  300
ggggcgggg  ctccagtca  tgtacaaag  cgtgaagac  cagccacag  aggcagcca  360
aggctcatc  tggcagcca  cagggatga  ttctacagc  gaccctcca  gttagctga  420
ttctggggg  acaacaacg  gatcctcag  gggctggac  tggaggaag  caaggaagg  480
ggcacatgg  tgggcatca  cacacgtgg  aagctggca  cactcacca  ctacctgca  540
ccgcagctg  actggcagg  ccgagggcg  gcacctacg  gctgagcaa  gcgctgctg  600
agactccct  gaggaagct  tgctttggg  agcagctct  cctggaggc  gtggaacgg  660
g  661



<210> 4436
<211> 478
<212> DNA
<213> Rattus norvegicus
<308> AA799663
<400> 4436

ccagcctca  agttttatt  tcaactgtg  acattcgag  tcacatccc  tggtgtaca  60
cttataaca  ggacagtga  agacggcag  ggctgcgtg  gccatttgg  gaaatggtc  120
tgctcagaa  ccacagtcc  gggcaagca  gggcctaag  gatcccagg  tccacacct  180
agcattgag  aaatgcaca  agagtcctt  tgcatacgg  actactgaa  gcaaacaaa  240
acagggtct  cagtttctg  tgccatagg  ggcagagcg  acacacaca  ctgcatact  300
gctcagtat  ggctgaata  actcctggc  ctggtcctc  atggctggg  ctggcagct  360
tgcctcctc  ttgttgagg  cttctagga  ctgggtgac  agaatgtcc  tagggagtg  420
ctcgctccg  tccactgct  ccgtgaaga  ttgcttgcc  aagcacagc  tcttccag  478



<210> 4437
<211> 276
<212> PRT
<213> Rattus norvegicus
<308> CAA52612
<400> 4437

Met Cys Ile Ile Phe Phe Lys Phe Asp Pro Arg Pro Val Ser Lys Asn 
  1               5                  10                  15
Ala Tyr Arg Leu Ile Leu Ala Ala Asn Arg Asp Glu Phe Tyr Asn Arg 
             20                  25                  30
Pro Ser Lys Leu Ala Asp Phe Trp Gly Asn Asn Ser Glu Ile Leu Ser 
         35                  40                  45
Gly Leu Asp Met Glu Glu Gly Lys Ala Gly Gly Thr Trp Leu Gly Ile 
     50                  55                  60
Ser Thr Arg Gly Lys Leu Gly Ala Leu Thr Asn Tyr Leu Gln Pro Arg 
 65                  70                  75                  80
Gln Glu Pro Asp Ala Arg Gly Arg Gly Glu Leu Val Ser His Phe Leu 
                 85                  90                  95
Thr Ser Asp Met Asp Ser Leu Ser Tyr Leu Lys Lys Val Ser Thr Glu 
             100                105                110
Gly His Leu Tyr Asn Gly Phe Asn Ile Ile Ala Ala Asp Leu Ser Thr 
         115                120                125
Ser Lys Gly Asp Val Val Cys Tyr Tyr Gly Asn Arg Gly Glu Pro Glu 
     130                135                140
Pro Ile Val Leu Thr Pro Gly Thr Tyr Gly Leu Ser Asn Ala Leu Leu 
 145                150                155                160
Glu Thr Pro Trp Lys Lys Leu Cys Phe Gly Lys Gln Leu Phe Met Glu 
                 165                170                175
Ala Val Glu Gln Ser Glu Ala Leu Pro Lys Asp Val Leu Val Thr Gln 
             180                185                190
Leu Leu Asp Val Leu Asn Asn Glu Glu Ala Gln Leu Pro Asp Pro Ala 
         195                200                205
Ile Glu Asp Gln Gly Gln Glu Tyr Val Gln Pro Ile Leu Asn Lys Tyr 
     210                215                220
Ala Ala Val Trp Cys Arg Cys Ala Ser Tyr Gly Thr Arg Thr Asn Thr 
 225                230                235                240
Ile Ile Leu Val Asp Ala Asn Gly His Val Thr Phe Thr Glu Arg Ser 
                 245                250                255
Met Leu Asp Lys Asp Thr Ser Arg Trp Glu Thr Asn Thr Tyr Glu Phe 
             260                265                270
Thr Leu Gln Ser 
         275



<210> 4438
<211> 661
<212> DNA
<213> Homo sapiens
<308> BG699621
<400> 4438

agcggagtc  gcggcggtg  cggaggcga  ctcgcgacc  gtgtcagca  agccgccct  60
caccaccat  tgcatcatc  tctttaagt  gatcctagc  ctgtttcca  aaacgcgta  120
aggtaaccc  ctcgctctg  atctgctgc  ccctgcagg  tcctgggtg  ccagccagt  180
ctcatgcca  ccaagctgc  gtgtgcagg  aggtgtgtg  gccaggacg  ggctgcaca  240
gcctggcac  gccctccag  acagggtca  tcagtgtgg  atgctgtca  aatgcctct  300
ggggcgggg  ctccagtca  tgtacaaag  cgtgaagac  cagccacag  aggcagcca  360
aggctcatc  tggcagcca  cagggatga  ttctacagc  gaccctcca  gttagctga  420
ttctggggg  acaacaacg  gatcctcag  gggctggac  tggaggaag  caaggaagg  480
ggcacatgg  tgggcatca  cacacgtgg  aagctggca  cactcacca  ctacctgca  540
ccgcagctg  actggcagg  ccgagggcg  gcacctacg  gctgagcaa  gcgctgctg  600
agactccct  gaggaagct  tgctttggg  agcagctct  cctggaggc  gtggaacgg  660
g  661



<210> 4439
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AA799667
<400> 4439

ataggccca  ttgcccagc  ggttgcagg  gatgggttc  cattttcta  gctcaagga  60
gggcggcct  tgcatacca  aggtgtctg  gtggcagca  ggagcttgc  gggcaggag  120
taggcgcag  tcaactggg  cagctattt  aaggtggtc  ccagcactg  ccaaagggg  180
acttgaatg  agcactgtc  cataggtgc  ccacaagca  gcccagaaa  gcagctcag  240
ctggggagc  tggcgcctc  cccacagtg  gggccaggc  aggcagagg  tgctccacg  300
ttgtcagga  gggctccct  gttcaaatc  cattcatag  cacagcttc  gacgtcagc  360
ggacatgga  aaagcaggc  gacccggcc  cagccccac  tgacccacc  atcctcttt  420
ggtgctggt  tttcaatga  gccctgagg  gaatggcca  ctgtcttcc  cccaggacc  480
cgcataggc  tcccagctt  tctctcccc  acagggcac  gtgcaggaa  tccagaaaa  540
t  541



<210> 4440
<211> 229
<212> PRT
<213> Rattus norvegicus
<308> CAB56623
<400> 4440

Gly Thr Arg Ile Ala Ser Val Asp His Ile Lys Phe Asp Leu Glu Ile 
  1               5                  10                  15
Ala Val Glu Gln Gln Leu Gly Ala Gln Pro Leu Pro Phe Pro Gly Met 
             20                  25                  30
Asp Lys Ser Gly Ala Ala Val Cys Glu Phe Phe Leu Lys Ala Ala Cys 
         35                  40                  45
Gly Lys Gly Gly Met Cys Pro Phe Arg His Ile Ser Gly Glu Lys Thr 
     50                  55                  60
Val Val Cys Lys His Trp Leu Arg Gly Leu Cys Lys Lys Gly Asp Gln 
 65                  70                  75                  80
Cys Glu Phe Leu His Glu Tyr Asp Met Thr Lys Met Pro Glu Cys Tyr 
                 85                  90                  95
Phe Tyr Ser Lys Phe Gly Glu Cys Ser Asn Lys Glu Cys Pro Phe Leu 
             100                105                110
His Ile Asp Pro Glu Ser Lys Ile Lys Asp Cys Pro Trp Tyr Asp Arg 
         115                120                125
Gly Phe Cys Lys His Gly Pro Leu Gln His Arg His Thr Arg Arg Val 
     130                135                140
Ile Cys Val Asn Tyr Leu Val Gly Phe Cys Pro Glu Gly Thr Ser Cys 
 145                150                155                160
Lys Phe Met His Pro Arg Phe Glu Leu Pro Met Gly Thr Thr Glu Gln 
                 165                170                175
Pro Pro Leu Pro Gln Gln Asn Ser Ser Asn Lys Pro Lys Pro Pro Arg 
             180                185                190
Ser Leu Gly Pro Ala Lys Ser Asn Thr Met Gln Ala Thr Gly Thr Pro 
         195                200                205
Ala Pro Glu Gln Phe Leu Ala Thr Ile Cys Glu Lys Glu Asp Met Cys 
     210                215                220
Phe Arg Trp Phe Pro 
 225



<210> 4441
<211> 1717
<212> DNA
<213> Homo sapiens
<308> NM_006693
<400> 4441

tcgctcgct  ctccttcgc  tcgcctcgc  gccgccatg  aggaaatca  cgccagcgt  60
gaccacatc  agtttgact  ggagatcgc  gtggagcag  agctggggg  gcagccgct  120
cccttcccc  gcatggaca  gtcgggcgc  gctgtctgt  aattctttt  gaaagctgc  180
tgcggcaaa  ggggcatgt  tccgtttcg  cacatcagt  gtgagaaga  agttgtgtg  240
aaacactgg  tgcgtggcc  atgcaagaa  ggggaccag  gtgagttcc  gcatgagta  300
gacatgacc  agatgcccg  gtgctactt  tactccaag  tcggggagt  cagcaacaa  360
gaatgtccc  tcctgcaca  cgaccccga  tccaagatc  aggactgtc  ttggtatga  420
cgcggcttc  gcaagcacg  tcccctctg  aggcaccgg  acacacgga  agtcatctg  480
gtgaattac  tcgtgggat  ctgcccgga  gggccctcg  gtaaattca  gcaccctcg  540
tttgaactg  ccatgggaa  caccgagca  cccccactg  cacagcaga  acagcctcc  600
gcaaagcaa  gtaacaatc  gccattaca  aggtcgtcc  ccttgatcc  gttaacgag  660
cagaactct  ctcccaatc  gcagagaac  ccgcaggtc  tcggggtca  gcagagtca  720
aacagcagc  cgggcaacc  gggaccccg  ccactggag  aggtcacct  ttacaagtg  780
ggcgagaaa  gacactacg  caacagatg  accaaaggg  acttggcct  tctcagtgg  840
cagtgacag  agctggagc  agctccgag  agcccgggg  ccccgctgt  gggagtgtg  900
atttaactg  ttcatgcgc  tgttggcgc  actgtggct  gagctggcc  gcagacacg  960
gggtttcat  actctgagg  gccacgtct  ttagtttcc  atcattttg  cgtagtatt  1020
tttgaaaaa  ggacatgtg  cctgtgggt  cctgcagtc  acatcatgt  tggctgggc  1080
tcgatgcct  ctttctggg  ctcccggca  aactcccct  atccaggga  ggaggcagc  1140
gctggggag  ggcttggct  ggtagttct  tgtggcggt  gtcattccc  tcattaaac  1200
ccagttctt  gtgacgcca  gggctggta  gtcattcaa  gctgtggcc  gctcacgcc  1260
gcttcctcc  tccctgccc  gctgaatcc  aaagctgtg  ctatatctg  gatttgaat  1320
agggagccc  ttggggcaa  ttcaggtgc  cccattgcc  caggctggc  ctggtccca  1380
gtggcagcg  ttgaggagg  gtacagggc  ctcaagcct  aggttttct  ctctgggct  1440
aattttctc  tggggtacg  gcctgacag  gtttaaggt  tccgttgaa  tggagttgc  1500
gacttttaa  tagatgacc  cttcagatc  tctgtgcct  cctcctgcc  atcaggcgt  1560
tacactgtc  ctcagacac  tgtggcatg  ggaggagac  gccctgtcc  gagcctgga  1620
aatgtgaaa  tgtctcctg  aacctgctg  gcatgtggg  ctggctgtg  tcaattgca  1680
gaacaattt  tatgaaatg  attaaagct  gtttttt  1717



<210> 4442
<211> 269
<212> PRT
<213> Homo sapiens
<308> NP_006684
<400> 4442

Met Gln Glu Ile Ile Ala Ser Val Asp His Ile Lys Phe Asp Leu Glu 
  1               5                  10                  15
Ile Ala Val Glu Gln Gln Leu Gly Ala Gln Pro Leu Pro Phe Pro Gly 
             20                  25                  30
Met Asp Lys Ser Gly Ala Ala Val Cys Glu Phe Phe Leu Lys Ala Ala 
         35                  40                  45
Cys Gly Lys Gly Gly Met Cys Pro Phe Arg His Ile Ser Gly Glu Lys 
     50                  55                  60
Thr Val Val Cys Lys His Trp Leu Arg Gly Leu Cys Lys Lys Gly Asp 
 65                  70                  75                  80
Gln Cys Glu Phe Leu His Glu Tyr Asp Met Thr Lys Met Pro Glu Cys 
                 85                  90                  95
Tyr Phe Tyr Ser Lys Phe Gly Glu Cys Ser Asn Lys Glu Cys Pro Phe 
             100                105                110
Leu His Ile Asp Pro Glu Ser Lys Ile Lys Asp Cys Pro Trp Tyr Asp 
         115                120                125
Arg Gly Phe Cys Lys His Gly Pro Leu Cys Arg His Arg His Thr Arg 
     130                135                140
Arg Val Ile Cys Val Asn Tyr Leu Val Gly Phe Cys Pro Glu Gly Pro 
 145                150                155                160
Ser Cys Lys Phe Met His Pro Arg Phe Glu Leu Pro Met Gly Thr Thr 
                 165                170                175
Glu Gln Pro Pro Leu Pro Gln Gln Thr Gln Pro Pro Ala Lys Gln Ser 
             180                185                190
Asn Asn Pro Pro Leu Gln Arg Ser Ser Ser Leu Ile Gln Leu Thr Ser 
         195                200                205
Gln Asn Ser Ser Pro Asn Gln Gln Arg Thr Pro Gln Val Ile Gly Val 
     210                215                220
Met Gln Ser Gln Asn Ser Ser Ala Gly Asn Arg Gly Pro Arg Pro Leu 
 225                230                235                240
Glu Gln Val Thr Cys Tyr Lys Cys Gly Glu Lys Gly His Tyr Ala Asn 
                 245                250                255
Arg Cys Thr Lys Gly His Leu Ala Phe Leu Ser Gly Gln 
             260                265



<210> 4443
<211> 616
<212> DNA
<213> Rattus norvegicus
<308> AA799672
<400> 4443

aaccttatg  agcagttta  ttaggttgt  aacaattag  acaccagtt  gtgagggta  60
atgccgttc  tcagggaga  ctgagaccg  aggtagccc  ggagctggg  gacagcttt  120
atctttggc  aaatctgcg  gtccacagc  ttctgatca  cctttcgct  ctctgtaat  180
tcgtatttc  ccttctctg  gtcgaagat  tcaccctcc  gatgcctgg  cttgcgaag  240
ggcttcttc  tgaagtaag  atcagtcag  tgtttggga  ttttaacct  gctgatatc  300
acttttgta  aggtggcga  gacaaactt  tggtgtgtc  tacgcagag  aactctgtt  360
agggcaaga  gtccagtca  aagtagcaa  gaccttttc  ttcttcttc  tcttctcaa  420
ctttgtctt  gcagcagag  atttccttt  gtacaaggc  tttctggaa  acatagcag  480
tcgtgaata  ctgccgatt  ctctcacca  gacagggtt  cggctgcaa  ggggcttac  540
cttcctcag  tttttagcc  tagaactac  ctttttgac  gcaccagcg  gccgggccc  600
gggggcagt  gcatca  616



<210> 4444
<211> 296
<212> PRT
<213> Rattus norvegicus
<308> P21533
<400> 4444

Ala Gly Glu Lys Ala Glu Lys Pro Asp Lys Lys Glu Gln Lys Pro Ala 
  1               5                  10                  15
Ala Lys Lys Ala Gly Gly Asp Ala Thr Ala Pro Arg Ala Gly Ala Trp 
             20                  25                  30
Cys Val Lys Lys Ser Ser Ser Lys Ala Lys Lys Leu Arg Lys Ser Lys 
         35                  40                  45
Pro His Cys Ser Arg Asn Pro Val Leu Val Arg Gly Ile Gly Arg Tyr 
     50                  55                  60
Ser Arg Ser Ala Met Tyr Ser Arg Lys Ala Leu Tyr Lys Arg Lys Tyr 
 65                  70                  75                  80
Ser Ala Ala Lys Thr Lys Val Glu Lys Lys Lys Lys Lys Glu Lys Val 
                 85                  90                  95
Leu Ala Thr Val Thr Lys Thr Val Gly Gly Asp Lys Asn Gly Gly Thr 
             100                105                110
Arg Val Val Lys Leu Arg Lys Met Pro Arg Tyr Tyr Pro Thr Glu Asp 
         115                120                125
Val Pro Arg Lys Leu Leu Ser His Gly Lys Lys Pro Phe Ser Gln His 
     130                135                140
Val Arg Arg Leu Arg Ser Ser Ile Thr Pro Gly Thr Val Leu Ile Ile 
 145                150                155                160
Leu Thr Gly Arg His Arg Gly Lys Arg Val Val Phe Leu Lys Gln Leu 
                 165                170                175
Gly Ser Gly Leu Leu Leu Val Thr Gly Pro Leu Ala Leu Asn Arg Val 
             180                185                190
Pro Leu Arg Arg Thr His Gln Lys Phe Val Ile Ala Thr Ser Thr Lys 
         195                200                205
Val Asp Ile Ser Lys Val Lys Ile Pro Lys His Leu Thr Asp Ala Tyr 
     210                215                220
Phe Lys Lys Lys Pro Leu Arg Lys Pro Arg His Gln Glu Gly Glu Ile 
 225                230                235                240
Phe Asp Thr Glu Lys Glu Lys Tyr Glu Ile Thr Glu Gln Arg Lys Ala 
                 245                250                255
Asp Gln Lys Ala Val Asp Ser Gln Ile Leu Pro Lys Ile Lys Ala Val 
             260                265                270
Pro Gln Leu Gln Gly Tyr Leu Arg Ser Gln Phe Ser Leu Thr Asn Gly 
         275                280                285
Met Tyr Pro His Lys Leu Val Phe 
     290                295



<210> 4445
<211> 252
<212> DNA
<213> Homo sapiens
<308> AA307406
<400> 4445

tgcaagatg  cgggtgaaa  agttgagaa  ccagatact  aagagaaga  acccgaagc  60
aagaaggtt  atgctggtg  caaggtgaa  angggtaac  tcaaagcta  aaagcccaa  120
anggggaag  cccattgca  ccgcaaccc  gtccttgtc  gaggaattn  caggtattc  180
cgatctgcc  tgtattcca  aaaggccat  tacaagagg  agtactcag  cgctaaatc  240
aaggttgaa  ag  252



<210> 4446
<211> 461
<212> DNA
<213> Rattus norvegicus
<308> AA799681
<400> 4446

ggatacggt  gctgtttgg  atctctcaa  atccctcgt  ctactgtgt  tgatgcata  60
ggaaacggc  gctcctgga  ggtacaatg  agccacata  acagtcggg  attggtctt  120
gactgacaa  tgcatggat  taagaaaac  gccgtacct  ggctctccc  gggtacaga  180
aaaggggtc  ccaattctc  ggtccaggg  aagtggttt  ggctttaga  aacacggca  240
ggtgattct  tggtcttta  tggagactt  aggctctgg  ggatggtct  ttccatccg  300
gagaagagt  cctggtggc  gggcatcct  gatggccgt  acgaacttg  caccgtgat  360
ccccacggt  tccaccagg  ctacctgcg  ttcctcccc  tctcggtaa  tcagatgga  420
cgatagatg  tcacttcag  anctaaact  acagaacat  n  461



<210> 4447
<211> 628
<212> DNA
<213> Rattus norvegicus
<308> AA799691
<400> 4447

agaacttta  tcttctact  acaaagtca  acaaaggca  aagcctata  aaaggaaaa  60
atgaaactg  tctgaatgg  cacagttac  aggaacacg  agtctgcga  ataaggagg  120
tggacactc  tgacaggca  ctcttgtaa  cagtgaccc  gaacctgaa  gggccacct  180
cccaaggca  tcctgacag  tgggagcag  gccccacct  ctctgctct  gacatcgag  240
gctcaggag  ctgagccaa  tccagtgct  agtcaaaag  aggtgtgga  atcactacc  300
tgatgggga  acacaccgg  cagcagtta  ttggcaagc  tacctctgg  tgcctaaca  360
agtctgaag  aactgtgca  gtgcaaact  ggcttctac  ctaaccaga  cgtcgtgag  420
gtggacggg  ttgattctc  cggaggaag  cagagatgc  cagagcctg  cagcacggg  480
catccacac  gaagctatc  ctatcaagc  tccccaggg  gggttaaat  aataaatat  540
ccacacaca  tgtgaggaa  ggatcactg  tgttgccca  agcctgtga  caaaccatg  600
cctacagaa  agaatgccc  aagggtaa  628



<210> 4448
<211> 1083
<212> PRT
<213> Rattus norvegicus
<308> AAD38328
<400> 4448

Met Pro Thr Asn Phe Thr Val Val Pro Val Glu Ala Arg Ala Asp Gly 
  1               5                  10                  15
Ala Gly Asp Glu Ala Ala Glu Arg Thr Glu Glu Pro Glu Ser Pro Glu 
             20                  25                  30
Ser Val Asp Gln Thr Ser Pro Thr Pro Gly Asp Gly Asn Pro Arg Glu 
         35                  40                  45
Asn Ser Pro Phe Ile Asn Asn Val Glu Val Glu Arg Glu Ser Tyr Phe 
     50                  55                  60
Glu Gly Lys Asn Met Ala Leu Phe Glu Glu Glu Met Asp Ser Asn Pro 
 65                  70                  75                  80
Met Val Ser Ser Leu Leu Asn Lys Leu Ala Asn Tyr Thr Asn Leu Ser 
                 85                  90                  95
Gln Gly Val Val Glu His Glu Glu Asp Glu Asp Ser Arg Arg Arg Glu 
             100                105                110
Val Lys Ala Pro Arg Met Gly Thr Phe Ile Gly Val Tyr Leu Pro Cys 
         115                120                125
Leu Gln Asn Ile Leu Gly Val Ile Leu Phe Leu Arg Leu Thr Trp Ile 
     130                135                140
Val Gly Ala Ala Gly Val Met Glu Ser Phe Leu Ile Val Ala Met Cys 
 145                150                155                160
Cys Thr Cys Thr Met Leu Thr Ala Ile Ser Met Ser Ala Ile Ala Thr 
                 165                170                175
Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Tyr Met Ile Ser Arg Ser 
             180                185                190
Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly 
         195                200                205
Thr Thr Phe Ala Gly Ala Met Tyr Ile Leu Gly Thr Ile Glu Ile Phe 
     210                215                220
Leu Thr Tyr Ile Ser Pro Ser Ala Ala Ile Phe Gln Ala Glu Thr Ala 
 225                230                235                240
Asp Gly Glu Ala Ala Ala Leu Leu Asn Asn Met Arg Val Tyr Gly Ser 
                 245                250                255
Cys Ala Leu Ala Leu Met Ala Val Val Val Phe Val Gly Val Lys Tyr 
             260                265                270
Val Asn Lys Leu Ala Leu Val Phe Leu Ala Cys Val Val Leu Ser Ile 
         275                280                285
Leu Ala Ile Tyr Ala Gly Val Ile Lys Thr Ala Phe Ala Pro Pro Asp 
     290                295                300
Ile Pro Val Cys Leu Leu Gly Asn Arg Thr Leu Ala Asn Arg Asn Phe 
 305                310                315                320
Asp Thr Cys Ala Lys Met Gln Val Val Ser Asn Gly Thr Val Thr Thr 
                 325                330                335
Ala Leu Trp Arg Leu Phe Cys Asn Gly Ser Ser Leu Gly Ala Thr Cys 
             340                345                350
Asp Glu Tyr Phe Ala Gln Asn Asn Val Thr Glu Ile Gln Gly Ile Pro 
         355                360                365
Gly Val Ala Ser Gly Val Phe Leu Asp Asn Leu Trp Ser Thr Tyr Ser 
     370                375                380
Asp Lys Gly Ala Phe Val Glu Lys Lys Gly Val Ser Ser Val Pro Val 
 385                390                395                400
Ser Glu Glu Ser Arg Pro Gly Gly Leu Pro Tyr Val Leu Thr Asp Ile 
                 405                410                415
Met Thr Tyr Phe Thr Met Leu Val Gly Ile Tyr Phe Pro Ser Val Thr 
             420                425                430
Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Lys Asp Ala Gln 
         435                440                445
Lys Ser Ile Pro Thr Gly Thr Ile Leu Ala Ile Val Thr Thr Ser Phe 
     450                455                460
Ile Tyr Leu Ser Cys Ile Val Leu Phe Gly Ala Cys Ile Glu Gly Val 
 465                470                475                480
Val Leu Arg Asp Lys Phe Gly Glu Ala Leu Gln Gly Asn Leu Val Ile 
                 485                490                495
Gly Met Leu Ala Trp Pro Ser Pro Trp Val Ile Val Ile Gly Ser Phe 
             500                505                510
Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg 
         515                520                525
Leu Leu Gln Ala Ile Ala Arg Asp Gly Ile Ile Pro Phe Leu Gln Val 
     530                535                540
Phe Gly His Gly Lys Ala Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu 
 545                550                555                560
Thr Ala Leu Ile Cys Glu Thr Gly Ile Leu Ile Ala Ser Leu Asp Ser 
                 565                570                575
Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Met Phe Val 
             580                585                590
Asn Leu Ala Cys Ala Val Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg 
         595                600                605
Pro Arg Phe Lys Phe Tyr His Trp Thr Leu Ser Phe Leu Gly Met Ser 
     610                615                620
Leu Cys Leu Ala Leu Met Phe Ile Cys Ser Trp Tyr Tyr Ala Leu Phe 
 625                630                635                640
Ala Met Leu Ile Ala Gly Cys Ile Tyr Lys Tyr Ile Glu Tyr Arg Gly 
                 645                650                655
Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Asn Ala 
             660                665                670
Ala Arg Tyr Ala Leu Leu Arg Val Glu His Gly Pro Pro His Thr Lys 
         675                680                685
Asn Trp Arg Pro Gln Val Leu Val Met Leu Asn Leu Asp Ser Glu Gln 
     690                695                700
Cys Val Lys His Pro Arg Leu Leu Ser Phe Thr Ser Gln Leu Lys Ala 
 705                710                715                720
Gly Lys Gly Leu Thr Ile Val Gly Ser Val Leu Glu Gly Thr Tyr Leu 
                 725                730                735
Asp Lys His Val Glu Ala Gln Arg Ala Glu Glu Asn Ile Arg Ser Leu 
             740                745                750
Met Ser Ala Glu Lys Thr Lys Gly Phe Cys Gln Leu Val Val Ser Ser 
         755                760                765
Asn Leu Arg Asp Gly Ala Ser His Leu Ile Gln Ser Ala Gly Leu Gly 
     770                775                780
Gly Met Lys His Asn Thr Val Leu Met Ala Trp Pro Glu Ala Trp Lys 
 785                790                795                800
Glu Ala Asp Asn Pro Phe Ser Trp Lys Asn Phe Val Asp Thr Val Arg 
                 805                810                815
Asp Thr Thr Ala Ala His Gln Ala Leu Leu Val Ala Lys Asn Ile Asp 
             820                825                830
Leu Phe Pro Gln Asn Gln Glu Arg Phe Ser Asp Gly Asn Ile Asp Val 
         835                840                845
Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu 
     850                855                860
Leu Arg Gln His Lys Val Trp Arg Lys Cys Arg Met Arg Ile Phe Thr 
 865                870                875                880
Val Ala Gln Val Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Gln 
                 885                890                895
Met Phe Leu Tyr His Leu Arg Ile Ser Ala Glu Val Glu Val Val Glu 
             900                905                910
Met Val Glu Asn Asp Ile Ser Ala Phe Thr Tyr Glu Lys Thr Leu Met 
         915                920                925
Met Glu Gln Arg Ser Gln Met Leu Lys Gln Met Gln Leu Ser Lys Asn 
     930                935                940
Glu Arg Glu Arg Glu Ala Gln Leu Ile His Asp Arg Asn Thr Ala Ser 
 945                950                955                960
His Thr Thr Ala Thr Ala Arg Thr Gln Ala Pro Pro Thr Pro Asp Lys 
                 965                970                975
Val Gln Met Thr Trp Thr Lys Glu Lys Leu Ile Ala Glu Lys His Arg 
             980                985                990
Asn Lys Asp Thr Gly Pro Ser Gly Phe Lys Asp Leu Phe Ser Leu Lys 
         995                1000                1005
Pro Asp Gln Ser Asn Val Arg Arg Met His Thr Ala Val Lys Leu Asn 
     1010                1015                1020
Gly Val Val Leu Asn Lys Ser Gln Asp Ala Gln Leu Val Leu Leu Asn 
 1025                1030                1035                1040
Met Pro Gly Pro Pro Lys Ser Arg Gln Gly Asp Glu Asn Tyr Met Glu 
                 1045                1050                1055
Phe Leu Glu Val Leu Thr Glu Gly Leu Asn Arg Val Leu Leu Val Arg 
             1060                1065                1070
Gly Gly Gly Arg Glu Val Ile Thr Ile Tyr Ser 
         1075                1080



<210> 4449
<211> 637
<212> DNA
<213> Rattus norvegicus
<308> AA799700
<400> 4449

ccaacaaag  cccttttat  tagttagct  ttaagaaat  ttttttatt  attaaatct  60
tggaaattt  cagtgtaag  tttagtatc  taacggccg  caacacctg  ctctgaggt  120
tgatcagcc  ctcccagtc  ttattagga  ttagaggga  aaacatcat  atcagagac  180
aagtcaggt  gctatggcc  tcctttcct  gctggacaa  ttgctcaac  cttgctcag  240
acaggaaaa  aggcagttg  tcagaaaaa  aattaatga  aaatttgac  ataaatcag  300
aagagttct  ctaacaatt  agacttatc  atatgttgg  ccagataat  tttttcatg  360
tgcagttta  ttttttctg  atgtaatct  aataatctt  ctccctgtg  agaaatgaa  420
caactcagt  caaaaaatc  ctaaaactg  aatagcctc  tcttgcttt  ggaaaaggt  480
tttttactc  tcattctct  aacagatga  cacacatcc  ctgcacttc  gggtctgga  540
gtacacagg  agcttttga  ggaactagc  aaagtacct  gaggcacta  gccggcagc  600
tttggaaag  tcttaaaat  aaccctggc  aacagtc  637



<210> 4450
<211> 452
<212> PRT
<213> Rattus norvegicus
<308> NP_033292
<400> 4450

Met Ala Glu Ala Ala Ala Ala Gly Ala Ser Gly Glu Thr Met Ala Ala 
  1               5                  10                  15
Leu Val Ala Ala Glu Gly Ser Leu Gly Pro Ala Gly Trp Ser Ala Gly 
             20                  25                  30
Arg Ser Phe Ser Asn Tyr Arg Pro Phe Glu Pro Gln Thr Leu Gly Phe 
         35                  40                  45
Ser Pro Ser Trp Arg Leu Thr Ser Phe Ser Gly Met Lys Gly Xaa Gly 
     50                  55                  60
Cys Lys Val Pro Gln Glu Thr Leu Leu Lys Leu Leu Glu Gly Leu Thr 
 65                  70                  75                  80
Arg Pro Ala Leu Gln Pro Pro Leu Thr Ser Gly Leu Val Gly Gly Gln 
                 85                  90                  95
Glu Glu Thr Val Gln Glu Gly Gly Leu Ser Thr Arg Pro Gly Pro Gly 
             100                105                110
Ser Ala Phe Pro Ser Leu Ser Ile Gly Met Asp Ser Cys Val Ile Pro 
         115                120                125
Leu Arg His Gly Gly Leu Ser Leu Val Gln Thr Thr Asp Phe Phe Tyr 
     130                135                140
Pro Leu Val Glu Asp Pro Tyr Met Met Gly Arg Ile Ala Cys Ala Asn 
 145                150                155                160
Val Leu Ser Asp Leu Tyr Ala Met Gly Ile Thr Glu Cys Asp Asn Met 
                 165                170                175
Leu Met Leu Leu Ser Val Ser Gln Ser Met Ser Glu Lys Glu Arg Glu 
             180                185                190
Lys Val Thr Pro Leu Met Ile Lys Gly Phe Arg Asp Ala Ala Glu Glu 
         195                200                205
Gly Gly Thr Ala Val Thr Gly Gly Gln Thr Val Val Asn Pro Trp Ile 
     210                215                220
Ile Ile Gly Gly Val Ala Thr Val Val Cys Gln Gln Asn Glu Phe Ile 
 225                230                235                240
Met Pro Asp Ser Ala Val Val Gly Asp Val Leu Val Leu Thr Lys Pro 
                 245                250                255
Leu Gly Thr Gln Val Ala Ala Asn Ala His Gln Trp Leu Asp Asn Pro 
             260                265                270
Glu Lys Trp Asn Lys Ile Lys Met Val Val Ser Arg Glu Glu Val Glu 
         275                280                285
Leu Ala Tyr Gln Glu Ala Met Phe Asn Met Ala Thr Leu Asn Arg Thr 
     290                295                300
Ala Ala Gly Leu Met His Thr Phe Asn Ala His Ala Ala Thr Asp Ile 
 305                310                315                320
Thr Gly Phe Gly Ile Leu Gly His Ser Gln Asn Leu Ala Lys Gln Gln 
                 325                330                335
Lys Asn Glu Val Ser Phe Val Ile His Asn Leu Pro Ile Ile Ala Lys 
             340                345                350
Met Ala Ala Ile Ser Lys Ala Ser Gly Arg Phe Gly Leu Leu Gln Gly 
         355                360                365
Thr Ser Ala Glu Thr Ser Gly Gly Leu Leu Ile Cys Leu Pro Arg Glu 
     370                375                380
Gln Ala Ala Arg Phe Cys Ser Glu Ile Lys Ser Ser Lys Tyr Gly Glu 
 385                390                395                400
Gly His Gln Ala Trp Ile Val Gly Ile Val Glu Lys Gly Asn Arg Thr 
                 405                410                415
Ala Arg Ile Ile Asp Lys Pro Arg Val Ile Glu Val Leu Pro Arg Gly 
             420                425                430
Ala Ser Ala Ala Ala Ala Ala Ala Pro Asp Asn Ser Asn Ala Ala Ser 
         435                440                445
Glu Pro Ser Ser 
     450



<210> 4451
<211> 2253
<212> DNA
<213> Homo sapiens
<308> NM_012248
<400> 4451

gtgcatgcc  tgggtctga  ggcttgagt  gcgctaggg  gaatccctg  aggtaatat  60
tgacttttg  ttcatatta  tctgagtgg  aaataaaag  gccctcttc  cctctcgct  120
ccctgccgg  caggcgcca  ggcggaagc  tcggcgacg  gcgcctgcg  agaggcgat  180
gcagcggcg  aaggctcct  gggcccggc  ggcttgact  tgggccgga  cttctcgaa  240
taccggccc  tcgagcccc  ggcgttggg  ctcagcccg  gctggcggc  gacgggctt  300
tccggcatg  agggctgag  ctgcaaggt  ccgcaggag  cgctgctca  actcctggc  360
ggactgacg  ggccggacg  gcggccccc  ctgggccgg  gcctggtgg  tggccagga  420
gaggcgtcc  aggaagccg  cctgccggc  ggagcgggc  ccagcccca  ctttccagc  480
ctgggcatc  ggatggact  ctgcgtcat  cccctgagg  acgggggcc  gtcactggt  540
cagaccacg  acttctttt  ccccttggt  gaagatccc  acatgatgg  gcgcatagc  600
tgtgccaac  tgctgagtg  cctctacgc  atggggatt  ctgagtgtg  caacatgtt  660
atgttactc  gcgtcagcc  gagtatgag  gaggaggaa  gcgaaaagg  aacgccact  720
atggtcaaa  gctttcggg  tgcggctga  gaaggaggg  cggcagtga  cggtgggca  780
acggtggtc  acccttgga  tataatcgg  ggagttgcc  ctgtagtat  ccaaccaaa  840
gagttcata  tgccggaca  cgccgtcgt  ggggacgtg  tggtgttaa  caaaccgtt  900
ggaacccag  ttgctgtca  tgcccacca  tggctggat  atcctgaaa  atggaataa  960
gtaaagatg  tggtctcca  agaagaggt  gagctggcc  atcaggaag  catgttcaa  1020
atggctacc  tcaacagaa  tgctgcagg  ttaatgcac  catttaatg  ccatgcggc  1080
acagatatc  caggctttg  cattctagg  cactcccag  accttgcaa  acaacaaag  1140
aatgaagtg  cctttgtta  tcataatct  ccaataatt  ccaagatgg  tgccgtcag  1200
aaggccagt  gacggtttg  gcttcttca  ggaacctca  ctgaaacct  tgggggatt  1260
ctgatttgt  tgccaagag  acaggcggc  cgcttttgt  ctgaaatca  atcctccaa  1320
tacggagag  gtcaccaag  gtggatcgt  ggcattgtg  aaaagggaa  ccgaacggc  1380
cggatcatt  acaagccgc  agttattga  gtcctgcct  gtggggcca  agctgctgt  1440
cttgctcct  acagttcaa  tgcctcctc  gagcctagc  cgtgagatg  aagaacaga  1500
gttgtttgg  ccttagagc  attgtccac  atcacggat  gttctcaag  gttgattgt  1560
agaaatttc  aaagaaggc  gcctgcata  tggttccgg  tgccctttc  aggtgattg  1620
aatcagccc  tctaaagca  tctttatat  cattccgag  ccagagtaa  attttgaac  1680
ttgggggga  atttgttca  cacttgggt  gaagaggag  aaaaatact  ctgttttct  1740
ttgccaaag  aagatgaag  tattccagg  tgagggatt  ttctttgca  ggggttgat  1800
aatttctgc  cagggagtg  gattattaa  gtaacacac  cacaaagta  attgcaaaa  1860
gaaaaaaat  agaagcaaa  gagttttgg  ccaatattg  tgataaatc  aaattgtta  1920
gagagatct  ataatgcaa  atcaaattc  ttattcaat  ttactgaag  actggctct  1980
tcctgctct  gacaagaat  gagcaactt  tctgatgac  gggaaagga  gacctgcaa  2040
catctgact  ggtctctgt  aatgacgtc  ctccctcta  accccatta  ggactggga  2100
aggcagagc  agcctcaga  cccaggcct  agtggtcat  aagatgtta  gtcttttgc  2160
gcagattcc  ggtgatttg  tcaataaag  gtaatttct  gctaaataa  taaaagaaa  2220
cttgttgaa  aactaaaaa  aaaaaaaaa  aaa  2253



<210> 4452
<211> 448
<212> PRT
<213> Homo sapiens
<308> Q99611
<400> 4452

Met Ala Glu Ala Ser Ala Thr Gly Ala Cys Gly Glu Ala Met Ala Ala 
  1               5                  10                  15
Ala Glu Gly Ser Ser Gly Pro Ala Gly Leu Thr Leu Gly Arg Ser Phe 
             20                  25                  30
Ser Asn Tyr Arg Pro Phe Glu Pro Gln Ala Leu Gly Leu Ser Pro Ser 
         35                  40                  45
Trp Arg Leu Thr Gly Phe Ser Gly Met Lys Gly Cys Gly Cys Lys Val 
     50                  55                  60
Pro Gln Glu Ala Leu Leu Lys Leu Leu Ala Gly Leu Thr Arg Pro Asp 
 65                  70                  75                  80
Val Arg Pro Pro Leu Gly Arg Gly Leu Val Gly Gly Gln Glu Glu Ala 
                 85                  90                  95
Ser Gln Glu Ala Gly Leu Pro Ala Gly Ala Gly Pro Ser Pro Thr Phe 
             100                105                110
Pro Ala Leu Gly Ile Gly Met Asp Ser Cys Val Ile Pro Leu Arg His 
         115                120                125
Gly Gly Leu Ser Leu Val Gln Thr Thr Asp Phe Phe Tyr Pro Leu Val 
     130                135                140
Glu Asp Pro Tyr Met Met Gly Arg Ile Ala Cys Ala Asn Val Leu Ser 
 145                150                155                160
Asp Leu Tyr Ala Met Gly Ile Thr Glu Cys Asp Asn Met Leu Met Leu 
                 165                170                175
Leu Ser Val Ser Gln Ser Met Ser Glu Glu Glu Arg Glu Lys Val Thr 
             180                185                190
Pro Leu Met Val Lys Gly Phe Arg Asp Ala Ala Glu Glu Gly Gly Thr 
         195                200                205
Ala Val Thr Gly Gly Gln Thr Val Val Asn Pro Trp Ile Ile Ile Gly 
     210                215                220
Gly Val Ala Thr Val Val Cys Gln Pro Asn Glu Phe Ile Met Pro Asp 
 225                230                235                240
Ser Ala Val Val Gly Asp Val Leu Val Leu Thr Lys Pro Leu Gly Thr 
                 245                250                255
Gln Val Ala Val Asn Ala His Gln Trp Leu Asp Asn Pro Glu Arg Trp 
             260                265                270
Asn Lys Val Lys Met Val Val Ser Arg Glu Glu Val Glu Leu Ala Tyr 
         275                280                285
Gln Glu Ala Met Phe Asn Met Ala Thr Leu Asn Arg Thr Ala Ala Gly 
     290                295                300
Leu Met His Thr Phe Asn Ala His Ala Ala Thr Asp Ile Thr Gly Phe 
 305                310                315                320
Gly Ile Leu Gly His Ser Gln Asn Leu Ala Lys Gln Gln Arg Asn Glu 
                 325                330                335
Val Ser Phe Val Ile His Asn Leu Pro Ile Ile Ala Lys Met Ala Ala 
             340                345                350
Val Ser Lys Ala Ser Gly Arg Phe Gly Leu Leu Gln Gly Thr Ser Ala 
         355                360                365
Glu Thr Ser Gly Gly Leu Leu Ile Cys Leu Pro Arg Glu Gln Ala Ala 
     370                375                380
Arg Phe Cys Ser Glu Ile Lys Ser Ser Lys Tyr Gly Glu Gly His Gln 
 385                390                395                400
Ala Trp Ile Val Gly Ile Val Glu Lys Gly Asn Arg Thr Ala Arg Ile 
                 405                410                415
Ile Asp Lys Pro Arg Val Ile Glu Val Leu Pro Arg Gly Ala Thr Ala 
             420                425                430
Ala Val Leu Ala Pro Asp Ser Ser Asn Ala Ser Ser Glu Pro Ser Ser 
         435                440                445



<210> 4453
<211> 586
<212> DNA
<213> Rattus norvegicus
<308> AA799711
<400> 4453

aagtaagta  actgtcgct  tcttcagac  caccagaaa  ggggatcag  tctcattac  60
gatggttgt  agccatcac  tggttgctg  gatttgaac  caggacctc  ggaagagca  120
tcagtgcta  taactgctg  gccatctct  cagctcctg  cctagtttt  aatgtcaat  180
cccacaggt  tcagatttc  gcccaagct  taagtgatc  ttgtctaaa  agcatttct  240
attgtaggc  tttctgtaa  ggtgccttg  ggcaagtct  atggagtgc  gccagctcc  300
aggtaggtg  gttcatggg  ccgttacta  ttcatgtgt  tgtgaaagc  cctcactct  360
gtcttttac  cggttctta  acggctcag  ttccccaag  actatcagt  aacaaggat  420
aggcggttg  tgccctcaa  tgcacagtg  ttctttttt  taaaaaagg  tttgcttct  480
tgtgtacaa  tatcttgct  acacatatg  gcaccctgg  gtctgaagc  accagaagt  540
agtgctgta  cctctgtgg  taaagctcc  gtcagctgt  aagtat  586



<210> 4454
<211> 586
<212> DNA
<213> Rattus norvegicus
<308> AA799711
<400> 4454

aagtaagta  actgtcgct  tcttcagac  caccagaaa  ggggatcag  tctcattac  60
gatggttgt  agccatcac  tggttgctg  gatttgaac  caggacctc  ggaagagca  120
tcagtgcta  taactgctg  gccatctct  cagctcctg  cctagtttt  aatgtcaat  180
cccacaggt  tcagatttc  gcccaagct  taagtgatc  ttgtctaaa  agcatttct  240
attgtaggc  tttctgtaa  ggtgccttg  ggcaagtct  atggagtgc  gccagctcc  300
aggtaggtg  gttcatggg  ccgttacta  ttcatgtgt  tgtgaaagc  cctcactct  360
gtcttttac  cggttctta  acggctcag  ttccccaag  actatcagt  aacaaggat  420
aggcggttg  tgccctcaa  tgcacagtg  ttctttttt  taaaaaagg  tttgcttct  480
tgtgtacaa  tatcttgct  acacatatg  gcaccctgg  gtctgaagc  accagaagt  540
agtgctgta  cctctgtgg  taaagctcc  gtcagctgt  aagtat  586



<210> 4455
<211> 571
<212> DNA
<213> Rattus norvegicus
<308> AA799718
<400> 4455

caaaaagag  aaacatgta  aaatccagg  tgctagaaa  acaaactca  ttcagattc  60
agcttgtct  gaccctggt  ataattccc  gtgaggtgc  tatgagcac  aagtcaggg  120
acgggacag  agtgaatcg  aggccaaga  aaagggtgg  gaggggatc  cctaggtct  180
ccggtgttc  cccctacag  ggtatctcc  tcttcccaa  gacttgaag  tctgccagg  240
ccagtcctc  tggccccaa  ctcacccta  ccagagcat  aaggccgat  gcaatcggt  300
ctcccttcc  ttgctcagt  ctcacttgc  ctggcttct  gccttattc  tgtcctcca  360
attcttctc  gtgattagt  gcaggttgg  ttctgtaga  agccacagt  aggctgggg  420
ccagaagag  tggggtgga  acgggatga  gacgaggga  gagctgtcc  aggacccct  480
tcttcatgg  atcccaaac  gtacaacca  ctcttcttt  gcatccacg  ggatctgag  540
aagtgcact  taggcataa  cagctatcc  g  571



<210> 4456
<211> 461
<212> DNA
<213> Homo sapiens
<308> AA806443
<400> 4456

ttttttttt  tctgtgaac  cagattcaa  ttttaagaa  taaacaaag  ttggccttt  60
ctagtccaa  atccctaag  ggggaaagg  gctggagca  gacttggac  ctattcccc  120
ggtgtggtg  tctcaattt  accagtatt  taaaagctt  ttatgtgcc  agcatgatg  180
tctgtcttc  tgttgcttg  tgtgataga  tcgtagatc  ccaaagctg  aaaggtctt  240
agtgaaggg  caactaagg  tgagagaga  gcaagtcag  ggcagtgct  gtacccagg  300
ccacactcc  gaccctcag  tcacagctc  ttttcagtg  gatgccctg  atgtctgta  360
tgcctggca  ggtccatgt  ctcatgctg  tccatgccc  gtgagtctg  agcagacac  420
tcaatgatg  tgctggctg  cttggcaag  atggaagag  g  461



<210> 4457
<211> 640
<212> DNA
<213> Rattus norvegicus
<308> AA799724
<400> 4457

aaacaaaag  gagaattta  taggcaaac  gacttgcag  gattccaaa  gctgtaatg  60
gtcaatagc  agagccaca  tttcctata  gacagaaca  gctgtagtc  ccaattcta  120
ttctgggct  tgtaccatc  tgagggtgg  cctgcttgt  ccctgcacg  gggactaga  180
cgtgggttc  tttttgctt  cctttttat  tttatagtc  tttacgctg  cctcaaact  240
gacaagcac  tgctggcag  cattcaaga  ctcattcag  cctttctga  acggctcaa  300
agctggaag  gcaccccgt  tctgaattc  caaattaat  ttgctctct  aaggatggg  360
cgtagtgta  ccacaaaat  ccacttccg  gttcttcat  attatgtac  gcagacaat  420
tcctagtgt  tggtcctcc  cgtgtagta  aaatgtcac  cactgtcta  ctgttccag  480
tgcctggac  atttccagg  ctgtcttcc  ctcgccttc  gccattgag  tcttcaatc  540
tgatatttt  ctctccagc  cctgatcgt  ctccatcgc  gggggcggc  ccgggaaat  600
ctcaggtgg  gctggcgaa  aggaagctc  tccccatgtc  640



<210> 4458
<211> 133
<212> PRT
<213> Rattus norvegicus
<308> NP_033113
<400> 4458

Met Glu Asp Asp Gln Glu Leu Glu Arg Lys Ile Ser Gly Leu Lys Thr 
  1               5                  10                  15
Ser Met Ala Glu Gly Glu Arg Lys Thr Ala Leu Glu Met Val Gln Ala 
             20                  25                  30
Ala Gly Thr Asp Arg Gln Cys Val Thr Phe Val Leu His Glu Glu Asp 
         35                  40                  45
His Thr Leu Gly Asn Cys Leu Arg Tyr Ile Ile Met Lys Asn Pro Glu 
     50                  55                  60
Val Glu Phe Cys Gly Tyr Thr Thr Thr His Pro Ser Glu Ser Lys Ile 
 65                  70                  75                  80
Asn Leu Arg Ile Gln Thr Arg Gly Ala Leu Pro Ala Val Glu Pro Phe 
                 85                  90                  95
Gln Lys Gly Leu Asn Glu Leu Leu Asn Val Cys Gln His Val Leu Val 
             100                105                110
Lys Phe Glu Ala Ser Ile Lys Asp Tyr Lys Ala Lys Lys Ala Ser Lys 
         115                120                125
Lys Glu Pro Thr Phe 
     130



<210> 4459
<211> 726
<212> DNA
<213> Homo sapiens
<308> NM_015972
<400> 4459

gccttcctt  ctgcttcgc  tccgcgcct  gcgctatgg  acagagccc  cgatccgcc  60
gcaccacct  aggatccag  aaccgcccc  gcgatggaa  aggatcagg  gctggagag  120
aaaatatct  gattgaaga  ctcaatggc  gaaggcgag  ggaagacag  cctggaaat  180
gtccaggca  ctggaacag  tagacactg  gtgacattt  tattgcacg  ggaagacca  240
accctagga  attctctac  ttacatgat  atgaagaac  cggaagtgg  attttgtgg  300
tacactacg  cccatcctt  agagagcaa  attaattta  gcattcaga  tcgaggtac  360
cttccagct  ttgagccat  tcagagagg  ctgaatgag  tcatgaatg  ctgccaaca  420
gtgcttgac  agtttgagg  cagcataaa  gactataag  atcaaaaag  aagcagaaa  480
gaatccaca  tctagtcct  tatgcagta  acaaggaga  ctgtcctgt  ggatattct  540
ttcctgatg  tgcagaacc  agaattaga  gtttgtggt  acagcatac  ctgtccttc  600
gaaaggcgt  attctagct  ttgacccct  gcagctgtt  gaatctctg  aagaacctc  660
gtattcttc  aataaattc  ctcttttat  taaaaaaaa  aaaaaaaaa  aaaaaaaaa  720
aaaaaa  726



<210> 4460
<211> 133
<212> PRT
<213> Homo sapiens
<308> Q9Y2S0
<400> 4460

Met Glu Glu Asp Gln Glu Leu Glu Arg Lys Ile Ser Gly Leu Lys Thr 
  1               5                  10                  15
Ser Met Ala Glu Gly Glu Arg Lys Thr Ala Leu Glu Met Val Gln Ala 
             20                  25                  30
Ala Gly Thr Asp Arg His Cys Val Thr Phe Val Leu His Glu Glu Asp 
         35                  40                  45
His Thr Leu Gly Asn Ser Leu Arg Tyr Met Ile Met Lys Asn Pro Glu 
     50                  55                  60
Val Glu Phe Cys Gly Tyr Thr Thr Thr His Pro Ser Glu Ser Lys Ile 
 65                  70                  75                  80
Asn Leu Arg Ile Gln Thr Arg Gly Thr Leu Pro Ala Val Glu Pro Phe 
                 85                  90                  95
Gln Arg Gly Leu Asn Glu Leu Met Asn Val Cys Gln His Val Leu Asp 
             100                105                110
Lys Phe Glu Ala Ser Ile Lys Asp Tyr Lys Asp Gln Lys Ala Ser Arg 
         115                120                125
Asn Glu Ser Thr Phe 
     130



<210> 4461
<211> 503
<212> DNA
<213> Rattus norvegicus
<308> AA799726
<400> 4461

gacatttca  agtcaattt  tacatgact  cacactttc  tagaagaac  cacatttgg  60
agtctctac  ctaaggagt  gcttcagta  atgggcaga  gcaatgtgt  tgctgaagg  120
gtcatacca  aaaagatag  tcagacagt  ccataatca  taaaaacag  gtagtacat  180
acaaatgac  gtgcattct  taaccaatt  cagtcggga  cctttctaa  tgtgtccga  240
attgccaat  caactgaca  gggttctcc  gtgggctgg  ctgagttaa  attgactcc  300
caccttgag  aaacaacgg  cctacataa  gcttcagaa  agctcatag  atgcactaa  360
gccattgct  ctcacagcc  tgggcaacc  atgaagatt  ttctggtcc  ctccagact  420
tctctaagt  ctggtctgc  ctcgggcct  aaaggattc  ctactggag  ctgtctgcc  480
ccagctgct  caggaacag  gca  503



<210> 4462
<211> 4221
<212> DNA
<213> Homo sapiens
<308> AB051524
<400> 4462

agggcagtc  agatgaaaa  agtaccaat  aatctgcct  cagctgaat  aaccatgga  60
aggaaaaac  catccagag  gagccccag  agactctct  ccaaagtag  caaaggcac  120
gagatgaag  aagtggctc  tcagcttgg  atggctgct  ctgagtcag  caaggactc  180
ggcttttca  atgggagct  ggaatgtct  agctctgca  agcagatgg  gtccgagga  240
atgctgagc  ccttaggct  gagcagaga  gacaggccg  ggcagaact  caaaactgc  300
aagaatgcc  tccctaccc  gtctcccat  gtcgtcatg  agaatgtgc  tgtcaaaca  360
ggcagcagc  catcccagc  ccagtcgtg  actgtccag  cctcctttg  agtgatctc  420
gcacagcca  agctcttat  ccttcatcc  cctgtacca  ctcctgtca  tccatgtca  480
actggtgag  aaaagtccg  ctccaggaa  tacttgccc  ttctgaatt  ttacaccaa  540
atagcccca  atccaggca  aaggggcct  tcccttggc  cagaagaaa  aggaacaag  600
ggagtgcag  agaaaatct  tactgagag  cttgggcct  gcttgtctt  cagtgagcc  660
accaaggct  gtgctgtcc  atccagtcc  tcgacgcca  caccaccca  cgccaaact  720
gccgaggac  cagctctgc  gggtgtgcc  tctctggtg  caggtggaa  tccacagac  780
cttcagccg  tatccagca  tcacgtggc  aaagctccc  gtctgacct  cgcttcccc  840
gccagtcct  tctgcgcat  agacagcac  ctccatggg  tagagagca  ctctcccct  900
tcaccactg  ccgctaatt  tagctcacc  ttatgggct  cagagcacc  ctgccgcag  960
ccagatatc  tttcagagc  gcggcagag  aaacatagg  gctttcaga  taccctagt  1020
gtcctacat  aatctggtt  gctggagat  actttgaaa  ccaaggagt  gattcgtca  1080
aatcaggca  ctcaggtag  actagacca  ctaaaggag  aaacccagc  gtttataga  1140
gccaccaag  gcagggccc  tcaggcttg  gccaagctg  aggcatctt  aacacctgg  1200
tccagtaat  caggcagtg  cctagaagc  ttctctgat  acccagcca  atagcacag  1260
ggcatattt  cctgttact  gagtggttc  tttagctca  ttgctgtta  ctactcctg  1320
ttcccaaag  ttatgtaag  gcttttcct  ctaaactta  actgtgttg  ggttcactt  1380
ggaagccac  tgccaatac  tggctgctg  cttaactcg  agtctgggc  caggataca  1440
atgtccccg  cccactgag  acctcagtt  gggagtgcc  ttgagcccc  tttccttag  1500
ctgcaggtg  ttcaatgga  catggggca  agcaggaga  gattgtgtg  ggctcttcc  1560
gctgtcacc  cccatcatc  cactctctc  ccaggatca  gggtacagt  acacgaatg  1620
gcatacaga  caacgcctg  tgagccagg  agtaggtga  acaaggaaa  cttcatgga  1680
cttcccttg  ctgtcttag  cacagagag  aataagagg  ggttgtttg  atcccacaa  1740
gcatcgtac  agttgggcg  gacctaaaa  tccctgggc  caggttgca  ctgggtgtg  1800
gcacttaat  actcaacgc  ttgttttct  acacttgaa  atcaaggga  agactagta  1860
catctgact  ctacacttt  attacaagt  agatttttc  taaactagc  ggcaaaaac  1920
gtacttcca  attttaagg  atggaatga  tgcagtaca  ctggaattg  agtcgatga  1980
ttgcttttt  gacttagaa  ctgaagaaa  tagacatag  cggcatatc  catggtcag  2040
agctggacg  ttctggtaa  ttaggcttt  tttctctct  cttttgaaa  agtgtaacc  2100
gttttatgt  taaatatct  aaggatagt  tcagtggtt  ctgggatgt  gtataagtt  2160
actctgctg  catcttgtt  ttttttttt  cctttattt  gataagtga  tattatgct  2220
gataaactt  gaattaaat  cagttgtct  gagggtatg  taagtccac  aaaaattgg  2280
aagcatctt  cccattttc  tcacatccc  aatttttat  tgttccatg  catagtgat  2340
ggaagcagt  acagagcag  gtcttctgt  tttccttca  gtgttagat  ttggcaaca  2400
agccagagg  gtaatgttg  ttatatgaa  ttcatctca  aatggagac  atgaccaga  2460
tttccagat  atacacgtt  ttttcagct  cattaaata  gcaactatg  ttctaaata  2520
taaagtttc  aaatattct  tcaatttaa  atttcatcc  cttgaaaat  tttgttctt  2580
acaaaatta  cttaataag  tctatatgg  cagcttcat  ttccttttt  ttttttttg  2640
gatggagtt  cgctcttgt  gcccaggcg  agtacaatg  tgggatctc  gctcactgc  2700
acctccgcc  cctgggttc  agtgattct  ctgccacag  ctcccaagt  gctgggatt  2760
caggtgcct  ccaccatgc  cagctaatt  ttgtatttt  agtagaaat  gggttttac  2820
gtgttggcc  ggctggtct  gaactcctg  cctcagttg  tccgcctgc  tcagcctcc  2880
aaagtgctg  gcttacagg  ctgagccac  acgctcagc  cagcttcac  ctgtctgca  2940
agaaaagtt  taccaagac  agaagtgaa  tatgacatt  cctaggtag  tgtaactct  3000
acatagttt  aaaagtatg  ggcttcaga  tgcctatac  ttgttcaca  acgtgtgat  3060
tagatatga  tgatttaga  gtgaacaac  tggtaacat  cctagactc  actcatgaa  3120
gcagaatta  tacctgctg  ttgctttct  aaagaattt  agaaatcag  gcaaatgtg  3180
ctttaggca  attcagctc  ttttaatat  tttctcttg  cccactctc  ttgcctccc  3240
tgaatctgt  tggtactat  gcagctcta  tctgtgcac  atgctagga  gcttccttt  3300
tggcagaat  tgtttggca  caaagctat  gagacaggt  cattcagaa  atcctgggc  3360
ccagtcatg  gtcttactg  gtcaaaaat  tgaaaacac  tgctgagaa  caaatttat  3420
ccattggaa  aaccctctg  ggagctata  gcctcttgg  ctcttcttc  tagattaag  3480
cttgcattt  cctccctgt  tcagtaaaa  atgatgaaa  ccactatca  tcctcactg  3540
tgagtggca  ggagaagca  caccactct  agctctttt  taatcttgt  acttagtgc  3600
agaagtctc  ccaggctat  accatgggc  tttgttctc  gttggagct  taagcagat  3660
aacccaagt  gagaagata  atcttggaa  gagagatcc  ttgagtcca  aagccagat  3720
agcaaatgg  ggaacctcg  aggtgacca  aaagatctc  atcggttgc  caaggctgt  3780
agtagtgat  gttttagcg  tgaataacg  aattggcta  gaagtactg  ggcagagct  3840
ctgttttct  aaggtgaga  gccattttt  gctcagagc  acccttaag  gaacttttg  3900
cagattttg  tggcattat  gaaatatat  tagaaaagt  gctgattgc  atggttatg  3960
gaatggaat  taatgacat  tgtaattta  tacactcat  ggtttttat  gattatagt  4020
ttgtctgac  ttttatttt  tactatggt  cctttagca  aaaagtaac  tttgtgcat  4080
tattgaagt  gtttttcag  tatgaattc  ttagggtag  aatttattt  gcaaatgtg  4140
attcttttg  gaaagtatg  agttttgca  aaattgact  tgaaatgtc  gagaaaaat  4200
aaagtcact  acttgaaac  t  4221



<210> 4463
<211> 579
<212> DNA
<213> Rattus norvegicus
<308> AA799732
<400> 4463

aggccatac  gggcttggg  tttgtagct  cttccaccg  gggtggggg  tgtcaaggg  60
ggtgctaca  aggaacaag  caaagccca  gcctggagg  atatgccca  agggaccca  120
attcccact  agcattcag  catggggcc  tctcatgac  ccattccta  tgcttggac  180
ttcccctcc  aatctgatc  gtgggtggc  gcgggcata  ccagggtct  gtcagctcc  240
cagagagat  aggcctgtt  gcagccgga  agtcagtag  ccccacaca  acaaggctg  300
ggtgccagc  atcctaggc  acagaggac  gcgaggacc  cccacttgg  cacagagcc  360
gctttccca  ttggcagcc  ctctgttgc  gcttcctga  gagttccag  aagttcatc  420
gcagcgtca  ctcctgagg  ttagtggtc  catagaaac  agctacccc  gccttctcc  480
gtgtgctct  ctggtcagc  accttccgg  ccagctcca  gacaatctt  cggtccatt  540
cctgctgct  ctcccggat  cggtgttcc  aggcctcta  579



<210> 4465
<211> 220
<212> PRT
<213> Homo sapiens
<308> Q14129
<400> 4465

Met Glu Arg Tyr Ala Gly Ala Leu Glu Glu Val Ala Asp Gly Ala Arg 
  1               5                  10                  15
Gln Gln Glu Arg His Tyr Gln Leu Leu Ser Ala Leu Gln Ser Leu Val 
             20                  25                  30
Lys Glu Leu Pro Ser Ser Phe Gln Gln Arg Leu Ser Tyr Thr Thr Leu 
         35                  40                  45
Ser Asp Leu Ala Leu Ala Leu Leu Asp Gly Thr Val Phe Glu Ile Val 
     50                  55                  60
Gln Gly Leu Leu Glu Ile Gln His Leu Thr Glu Lys Ser Leu Tyr Asn 
 65                  70                  75                  80
Gln Arg Leu Arg Leu Gln Asn Glu His Arg Val Leu Arg Gln Ala Leu 
                 85                  90                  95
Arg Gln Lys His Gln Glu Ala Gln Gln Ala Cys Arg Pro His Asn Leu 
             100                105                110
Pro Val Leu Gln Ala Ala Gln Gln Arg Glu Leu Glu Ala Val Glu His 
         115                120                125
Arg Ile Arg Glu Glu Gln Arg Ala Met Asp Gln Lys Ile Val Leu Glu 
     130                135                140
Leu Asp Arg Lys Val Ala Asp Gln Gln Ser Thr Leu Glu Lys Ala Gly 
 145                150                155                160
Val Ala Gly Phe Tyr Val Thr Thr Asn Pro Gln Glu Leu Met Leu Gln 
                 165                170                175
Met Asn Leu Leu Glu Leu Ile Arg Lys Leu Gln Gln Arg Gly Cys Trp 
             180                185                190
Ala Gly Lys Ala Ala Leu Gly Leu Gly Gly Pro Trp Gln Leu Pro Ala 
         195                200                205
Ala Gln Cys Asp Gln Lys Gly Ser Pro Val Pro Pro 
     210                215                220



<210> 4466
<211> 581
<212> DNA
<213> Rattus norvegicus
<308> AA799735
<400> 4466

aacataaat  aaggcttta  tgttcagtt  ggatgaatg  cagactggc  taagctcga  60
taattgttc  acacattta  gaccccagg  tgacagcaa  agctatgct  attggcaat  120
ggcaacagg  agggagggg  tgggaagga  ctgaaggcc  ctgaagttc  agaaagcta  180
cgggaccga  accaacgtc  tagaagcag  tccaggatg  aaaagggat  atccaaagc  240
gaagatctt  gaggatctg  atcacttct  gaactgtca  gggcttctt  atgggtcac  300
gtggtctct  tccggccct  actgtccac  acagtgcgg  gttcctcca  tgtcccatc  360
ggcttagtg  tcttggtca  agagatgct  ttgaaatag  atttaggct  gggttgaag  420
agtggaccc  gaccttcct  ggaaacctg  gagtcaaga  ccttgtcct  tctggctct  480
gaatgggga  tcacaggcc  tgtatcatc  aacctatga  aaggtccct  ggaccccca  540
tctggagct  gtttggagg  ttcaggttt  gcatgactc  c  581



<210> 4467
<211> 280
<212> PRT
<213> Rattus norvegicus
<308> AAH06688
<400> 4467

Met Ser Val Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro 
  1               5                  10                  15
Arg Ser His Arg Asp Pro Phe Phe Gly Gly Met Thr Arg Asp Asp Asp 
             20                  25                  30
Asp Asp Asp Asp Asp Asp Asp Glu Ala Glu Glu Asp Arg Gly Ala Trp 
         35                  40                  45
Gly Arg Glu Ser Tyr Ala Phe Asp Gly Ser Gln Pro Pro Glu Glu Phe 
     50                  55                  60
Gly Phe Ser Phe Ser Pro Arg Gly Gly Met Arg Phe His Gly Asn Phe 
 65                  70                  75                  80
Gly Phe Asp Asp Leu Val Arg Asp Phe Asn Ser Ile Phe Ser Glu Met 
                 85                  90                  95
Gly Ala Trp Thr Leu Pro Ser His Ser Pro Glu Leu Pro Gly Pro Glu 
             100                105                110
Ser Glu Thr Pro Gly Glu Arg Leu Arg Glu Gly Gln Thr Leu Arg Asp 
         115                120                125
Ser Met Leu Lys Tyr Pro Asp Ser His Gln Pro Arg Ile Phe Glu Gly 
     130                135                140
Val Leu Glu Ser His Ala Lys Pro Glu Ser Pro Lys Pro Ala Pro Asp 
 145                150                155                160
Trp Gly Ser Gln Gly Pro Phe His Arg Leu Asp Asp Thr Trp Pro Val 
                 165                170                175
Ser Pro His Ser Arg Ala Lys Glu Asp Lys Asp Leu Asp Ser Gln Val 
             180                185                190
Ser Gln Glu Gly Leu Gly Pro Leu Leu Gln Pro Gln Pro Lys Ser Tyr 
         195                200                205
Phe Lys Ser Ile Ser Val Thr Lys Ile Thr Lys Pro Asp Gly Thr Val 
     210                215                220
Glu Glu Arg Arg Thr Val Val Asp Ser Glu Gly Arg Arg Glu Thr Thr 
 225                230                235                240
Val Thr His Gln Glu Ala His Asp Ser Ser Arg Ser Asp Pro Asp Ser 
                 245                250                255
Gln Arg Ser Ser Ala Leu Asp Asp Pro Phe Ser Ile Leu Asp Leu Leu 
             260                265                270
Leu Gly Arg Trp Phe Arg Ser Arg 
         275                280



<210> 4468
<211> 1225
<212> DNA
<213> Homo sapiens
<308> Y17829
<400> 4468

agacggaga  attcctttg  aagttattc  gtagcataa  agctgaaac  tcagagcaa  60
ttttcattg  gcaaaatgg  ggaacaacc  atcttcagc  ctcgagctc  tgtcttcca  120
attgaccca  acacaaaga  gaactgggt  cccaccagc  agcatgcag  tactgtgtc  180
tatttctat  acagcacaa  aaatgtgta  aggataatc  gtttagatg  ctcaaaggc  240
ataataaat  gtaccatca  cccaaacat  acatttact  aaacatctc  gaagtttgg  300
cagtgggct  atagccggg  aaacaccgt  tatggattg  gattctcct  tgagcatca  360
ctttcgaaa  ttgcagaaa  gtttcagga  tttaaagaa  ctgctcgac  agcaaagga  420
aaatcacaa  agaagatgg  acttaccag  acaccttca  aggaatccg  aggcgggga  480
cttcagtct  ctttaacac  ggaaagtat  aacgggaca  atgatgaaa  aacacctga  540
gtgacacag  actcagagc  aagggctga  ccaactcag  atgcattgc  attttcaca  600
agttcagca  tcagcaaac  ttgggaggc  gaactggct  ccctcaaag  aaataatgc  660
aaactcact  cagccctgc  ggagtccac  gccaatgtg  aacaatgga  acagcaact  720
gctgcctat  aagaggaag  agaacgtct  cacaagcgg  tgactgaac  tgaatgtgt  780
agtagccaa  caaatgcag  acatactca  aagacagaa  taaatcaga  aatacaaga  840
ctggaagag  cactgaaac  gaaggaaga  gaaatagaa  ggttaaaac  agaaattga  900
aatgccaga  aactacaag  acagaggga  tctttgact  agaaactac  ggaagtaga  960
attcggaac  aagacctgg  gggacaact  tctgactta  agcaacgtc  ggagaaaag  1020
cagaatgaa  aagaagctt  tcgcaataa  ctgaagaca  tcttagaaa  tctggatgg  1080
aagatattt  aactaacag  attacgaga  aacttggcc  agctactag  atgcagcta  1140
ggaaagtga  atttcagtg  caattaatt  aaagataca  tgtctctct  cataggact  1200
tttaggctc  gcatcaaga  tgcac  1225



<210> 4469
<211> 355
<212> PRT
<213> Homo sapiens
<308> Y17829
<400> 4469

Met Gly Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val Phe Gln Ile 
  1               5                  10                  15
Asp Pro Asn Thr Lys Lys Asn Trp Val Pro Thr Ser Lys His Ala Val 
             20                  25                  30
Thr Val Ser Tyr Phe Tyr Asp Ser Thr Arg Asn Val Tyr Arg Ile Ile 
         35                  40                  45
Ser Leu Asp Gly Ser Lys Ala Ile Ile Asn Ser Thr Ile Thr Pro Asn 
     50                  55                  60
Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp Ala Asp Ser 
 65                  70                  75                  80
Arg Ala Asn Thr Val Tyr Gly Leu Gly Phe Ser Ser Glu His His Leu 
                 85                  90                  95
Ser Lys Phe Ala Glu Lys Phe Gln Glu Phe Lys Glu Ala Ala Arg Leu 
             100                105                110
Ala Lys Glu Lys Ser Gln Glu Lys Met Glu Leu Thr Ser Thr Pro Ser 
         115                120                125
Gln Glu Ser Ala Gly Gly Asp Leu Gln Ser Pro Leu Thr Pro Glu Ser 
     130                135                140
Ile Asn Gly Thr Asp Asp Glu Arg Thr Pro Asp Val Thr Gln Asn Ser 
 145                150                155                160
Glu Pro Arg Ala Glu Pro Thr Gln Asn Ala Leu Pro Phe Ser His Ser 
                 165                170                175
Ser Ala Ile Ser Lys His Trp Glu Ala Glu Leu Ala Thr Leu Lys Gly 
             180                185                190
Asn Asn Ala Lys Leu Thr Ala Ala Leu Leu Glu Ser Thr Ala Asn Val 
         195                200                205
Lys Gln Trp Lys Gln Gln Leu Ala Ala Tyr Gln Glu Glu Ala Glu Arg 
     210                215                220
Leu His Lys Arg Val Thr Glu Leu Glu Cys Val Ser Ser Gln Ala Asn 
 225                230                235                240
Ala Val His Thr His Lys Thr Glu Leu Asn Gln Thr Ile Gln Glu Leu 
                 245                250                255
Glu Glu Thr Leu Lys Leu Lys Glu Glu Glu Ile Glu Arg Leu Lys Gln 
             260                265                270
Glu Ile Asp Asn Ala Arg Glu Leu Gln Glu Gln Arg Asp Ser Leu Thr 
         275                280                285
Gln Lys Leu Gln Glu Val Glu Ile Arg Asn Lys Asp Leu Glu Gly Gln 
     290                295                300
Leu Ser Asp Leu Glu Gln Arg Leu Glu Lys Ser Gln Asn Glu Gln Glu 
 305                310                315                320
Ala Phe Arg Asn Asn Leu Lys Thr Leu Leu Glu Ile Leu Asp Gly Lys 
                 325                330                335
Ile Phe Glu Leu Thr Glu Leu Arg Asp Asn Leu Ala Lys Leu Leu Glu 
             340                345                350
Cys Ser Ter 
         355



<210> 4470
<211> 581
<212> DNA
<213> Rattus norvegicus
<308> AA799735
<400> 4470

aacataaat  aaggcttta  tgttcagtt  ggatgaatg  cagactggc  taagctcga  60
taattgttc  acacattta  gaccccagg  tgacagcaa  agctatgct  attggcaat  120
ggcaacagg  agggagggg  tgggaagga  ctgaaggcc  ctgaagttc  agaaagcta  180
cgggaccga  accaacgtc  tagaagcag  tccaggatg  aaaagggat  atccaaagc  240
gaagatctt  gaggatctg  atcacttct  gaactgtca  gggcttctt  atgggtcac  300
gtggtctct  tccggccct  actgtccac  acagtgcgg  gttcctcca  tgtcccatc  360
ggcttagtg  tcttggtca  agagatgct  ttgaaatag  atttaggct  gggttgaag  420
agtggaccc  gaccttcct  ggaaacctg  gagtcaaga  ccttgtcct  tctggctct  480
gaatgggga  tcacaggcc  tgtatcatc  aacctatga  aaggtccct  ggaccccca  540
tctggagct  gtttggagg  ttcaggttt  gcatgactc  c  581



<210> 4471
<211> 280
<212> PRT
<213> Rattus norvegicus
<308> AAH06688
<400> 4471

Met Ser Val Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro 
  1               5                  10                  15
Arg Ser His Arg Asp Pro Phe Phe Gly Gly Met Thr Arg Asp Asp Asp 
             20                  25                  30
Asp Asp Asp Asp Asp Asp Asp Glu Ala Glu Glu Asp Arg Gly Ala Trp 
         35                  40                  45
Gly Arg Glu Ser Tyr Ala Phe Asp Gly Ser Gln Pro Pro Glu Glu Phe 
     50                  55                  60
Gly Phe Ser Phe Ser Pro Arg Gly Gly Met Arg Phe His Gly Asn Phe 
 65                  70                  75                  80
Gly Phe Asp Asp Leu Val Arg Asp Phe Asn Ser Ile Phe Ser Glu Met 
                 85                  90                  95
Gly Ala Trp Thr Leu Pro Ser His Ser Pro Glu Leu Pro Gly Pro Glu 
             100                105                110
Ser Glu Thr Pro Gly Glu Arg Leu Arg Glu Gly Gln Thr Leu Arg Asp 
         115                120                125
Ser Met Leu Lys Tyr Pro Asp Ser His Gln Pro Arg Ile Phe Glu Gly 
     130                135                140
Val Leu Glu Ser His Ala Lys Pro Glu Ser Pro Lys Pro Ala Pro Asp 
 145                150                155                160
Trp Gly Ser Gln Gly Pro Phe His Arg Leu Asp Asp Thr Trp Pro Val 
                 165                170                175
Ser Pro His Ser Arg Ala Lys Glu Asp Lys Asp Leu Asp Ser Gln Val 
             180                185                190
Ser Gln Glu Gly Leu Gly Pro Leu Leu Gln Pro Gln Pro Lys Ser Tyr 
         195                200                205
Phe Lys Ser Ile Ser Val Thr Lys Ile Thr Lys Pro Asp Gly Thr Val 
     210                215                220
Glu Glu Arg Arg Thr Val Val Asp Ser Glu Gly Arg Arg Glu Thr Thr 
 225                230                235                240
Val Thr His Gln Glu Ala His Asp Ser Ser Arg Ser Asp Pro Asp Ser 
                 245                250                255
Gln Arg Ser Ser Ala Leu Asp Asp Pro Phe Ser Ile Leu Asp Leu Leu 
             260                265                270
Leu Gly Arg Trp Phe Arg Ser Arg 
         275                280



<210> 4472
<211> 1225
<212> DNA
<213> Homo sapiens
<308> Y17829
<400> 4472

agacggaga  attcctttg  aagttattc  gtagcataa  agctgaaac  tcagagcaa  60
ttttcattg  gcaaaatgg  ggaacaacc  atcttcagc  ctcgagctc  tgtcttcca  120
attgaccca  acacaaaga  gaactgggt  cccaccagc  agcatgcag  tactgtgtc  180
tatttctat  acagcacaa  aaatgtgta  aggataatc  gtttagatg  ctcaaaggc  240
ataataaat  gtaccatca  cccaaacat  acatttact  aaacatctc  gaagtttgg  300
cagtgggct  atagccggg  aaacaccgt  tatggattg  gattctcct  tgagcatca  360
ctttcgaaa  ttgcagaaa  gtttcagga  tttaaagaa  ctgctcgac  agcaaagga  420
aaatcacaa  agaagatgg  acttaccag  acaccttca  aggaatccg  aggcgggga  480
cttcagtct  ctttaacac  ggaaagtat  aacgggaca  atgatgaaa  aacacctga  540
gtgacacag  actcagagc  aagggctga  ccaactcag  atgcattgc  attttcaca  600
agttcagca  tcagcaaac  ttgggaggc  gaactggct  ccctcaaag  aaataatgc  660
aaactcact  cagccctgc  ggagtccac  gccaatgtg  aacaatgga  acagcaact  720
gctgcctat  aagaggaag  agaacgtct  cacaagcgg  tgactgaac  tgaatgtgt  780
agtagccaa  caaatgcag  acatactca  aagacagaa  taaatcaga  aatacaaga  840
ctggaagag  cactgaaac  gaaggaaga  gaaatagaa  ggttaaaac  agaaattga  900
aatgccaga  aactacaag  acagaggga  tctttgact  agaaactac  ggaagtaga  960
attcggaac  aagacctgg  gggacaact  tctgactta  agcaacgtc  ggagaaaag  1020
cagaatgaa  aagaagctt  tcgcaataa  ctgaagaca  tcttagaaa  tctggatgg  1080
aagatattt  aactaacag  attacgaga  aacttggcc  agctactag  atgcagcta  1140
ggaaagtga  atttcagtg  caattaatt  aaagataca  tgtctctct  cataggact  1200
tttaggctc  gcatcaaga  tgcac  1225



<210> 4473
<211> 355
<212> PRT
<213> Homo sapiens
<308> Y17829
<400> 4473

Met Gly Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val Phe Gln Ile 
  1               5                  10                  15
Asp Pro Asn Thr Lys Lys Asn Trp Val Pro Thr Ser Lys His Ala Val 
             20                  25                  30
Thr Val Ser Tyr Phe Tyr Asp Ser Thr Arg Asn Val Tyr Arg Ile Ile 
         35                  40                  45
Ser Leu Asp Gly Ser Lys Ala Ile Ile Asn Ser Thr Ile Thr Pro Asn 
     50                  55                  60
Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp Ala Asp Ser 
 65                  70                  75                  80
Arg Ala Asn Thr Val Tyr Gly Leu Gly Phe Ser Ser Glu His His Leu 
                 85                  90                  95
Ser Lys Phe Ala Glu Lys Phe Gln Glu Phe Lys Glu Ala Ala Arg Leu 
             100                105                110
Ala Lys Glu Lys Ser Gln Glu Lys Met Glu Leu Thr Ser Thr Pro Ser 
         115                120                125
Gln Glu Ser Ala Gly Gly Asp Leu Gln Ser Pro Leu Thr Pro Glu Ser 
     130                135                140
Ile Asn Gly Thr Asp Asp Glu Arg Thr Pro Asp Val Thr Gln Asn Ser 
 145                150                155                160
Glu Pro Arg Ala Glu Pro Thr Gln Asn Ala Leu Pro Phe Ser His Ser 
                 165                170                175
Ser Ala Ile Ser Lys His Trp Glu Ala Glu Leu Ala Thr Leu Lys Gly 
             180                185                190
Asn Asn Ala Lys Leu Thr Ala Ala Leu Leu Glu Ser Thr Ala Asn Val 
         195                200                205
Lys Gln Trp Lys Gln Gln Leu Ala Ala Tyr Gln Glu Glu Ala Glu Arg 
     210                215                220
Leu His Lys Arg Val Thr Glu Leu Glu Cys Val Ser Ser Gln Ala Asn 
 225                230                235                240
Ala Val His Thr His Lys Thr Glu Leu Asn Gln Thr Ile Gln Glu Leu 
                 245                250                255
Glu Glu Thr Leu Lys Leu Lys Glu Glu Glu Ile Glu Arg Leu Lys Gln 
             260                265                270
Glu Ile Asp Asn Ala Arg Glu Leu Gln Glu Gln Arg Asp Ser Leu Thr 
         275                280                285
Gln Lys Leu Gln Glu Val Glu Ile Arg Asn Lys Asp Leu Glu Gly Gln 
     290                295                300
Leu Ser Asp Leu Glu Gln Arg Leu Glu Lys Ser Gln Asn Glu Gln Glu 
 305                310                315                320
Ala Phe Arg Asn Asn Leu Lys Thr Leu Leu Glu Ile Leu Asp Gly Lys 
                 325                330                335
Ile Phe Glu Leu Thr Glu Leu Arg Asp Asn Leu Ala Lys Leu Leu Glu 
             340                345                350
Cys Ser Ter 
         355



<210> 4474
<211> 658
<212> DNA
<213> Rattus norvegicus
<308> AA799740
<400> 4474

accagaaac  aagctgtta  tttattcta  agaaaggag  agaacacat  ttgcaggtg  60
cttgtttag  gggcttggg  acataaaca  tagcacctt  tcaggcctg  cattcaaag  120
cgggcagga  caaagaccc  ttgtaagtc  gctatagca  acgtaatgg  acattgatt  180
attttcttc  acagaaatg  tgcgtctac  aaccgaggc  ccacaaata  tcttacaaa  240
gtctactgt  ttgtgagtc  ctgaggttc  ctatacaca  caataaccg  gatggccat  300
atgcactaa  cgtcgccga  caatcaggg  acgcagaga  cactggcgt  tacatgact  360
tgcgtagca  cgtttgtta  tcgggctgc  gagcgatta  gttcccgag  attcgacaa  420
ggttatttt  gtgtctcga  gtctgattt  gctgtaaga  gtaaaaagc  tacagtcag  480
cgatgtgct  ggtcatgag  aatggctta  gtgtaaaaa  gacctacta  gtaattcca  540
acataaatc  ttggtgcta  atccttagg  taaaaatat  cattggcaa  gaaatcctt  600
cttaaaggg  aaaagaaca  cgaagaggg  ggaatgtgc  ccgaaactc  aggctcaa  658



<210> 4475
<211> 568
<212> DNA
<213> Rattus norvegicus
<308> AA799745
<400> 4475

aagccttcc  tgataacca  aagaagcaa  tgtgcctta  gctgagagc  acagagcca  60
tcagacttc  tgcagaggt  acaatgaat  ctggtgcca  cactcaggt  gcccttcct  120
gtggctctg  ctccaggtc  gctggcttc  tgctggtga  gtccagcaa  accagcctg  180
gctgtccca  cccccacca  gaagctggg  ggaggacac  gagggagca  gtcacacag  240
ggtccccat  aggttcaca  gacggccgt  gtatctctt  gagatgtca  cttcaatca  300
cttcttcag  gaggggatc  catagttga  attccgaac  aggaggcta  agagttcca  360
taaataggt  ttgtccttc  catacaggc  tatgatctc  tgccaatcc  tcatccgct  420
tgaagagta  cggccaaaa  tatttttgg  ggaagcctc  gtaccttta  gaaggtcca  480
tattcttag  cagtggaag  agtggatgt  ggaaccaga  agcagctgg  caatctctt  540
gctctctgg  atgtcctgg  tggcggtg  568



<210> 4476
<211> 504
<212> PRT
<213> Rattus norvegicus
<308> AAF60222
<400> 4476

Met Gln Asp His Gln His Val Pro Ile Asp Ile Gln Thr Ser Lys Leu 
  1               5                  10                  15
Leu Asp Trp Leu Val Asp Arg Arg His Cys Asn Leu Lys Trp Gln Ser 
             20                  25                  30
Leu Val Leu Thr Ile Arg Glu Lys Ile Asn Thr Ala Ile Gln Asp Met 
         35                  40                  45
Pro Glu Ser Gln Glu Ile Ala Gln Leu Leu Ser Gly Ser Tyr Ile His 
     50                  55                  60
Tyr Phe His Cys Leu Arg Ile Val Asp Leu Leu Lys Gly Thr Glu Ala 
 65                  70                  75                  80
Ser Thr Lys Asn Ile Phe Gly Arg Tyr Ser Ser Gln Arg Met Lys Asp 
                 85                  90                  95
Trp Gln Glu Ile Ile Ser Leu Tyr Glu Lys Asp Asn Thr Tyr Leu Val 
             100                105                110
Glu Leu Ser Ser Leu Leu Val Arg Asn Val Asn Tyr Glu Ile Pro Ser 
         115                120                125
Leu Lys Lys Gln Ile Ala Lys Cys Gln Gln Leu Gln Gln Asp Tyr Ser 
     130                135                140
Arg Lys Glu Glu Glu Gly Gln Ala Gly Ala Ala Glu Met Arg Glu Gln 
 145                150                155                160
Phe Tyr His Ser Cys Lys Gln Tyr Gly Ile Thr Gly Asp Asn Val Arg 
                 165                170                175
Arg Glu Leu Leu Ala Leu Val Lys Asp Leu Pro Ser Gln Leu Ala Glu 
             180                185                190
Ile Gly Ala Gly Ala Gln Ser Leu Gly Glu Ala Ile Asp Leu Tyr Gln 
         195                200                205
Ala Cys Val Glu Phe Val Cys Asp Ser Pro Thr Glu Gln Val Leu Pro 
     210                215                220
Met Leu Arg Tyr Val Gln Pro Lys Gly Asn Ser Thr Val Tyr Glu Trp 
 225                230                235                240
Arg Thr Gly Thr Glu Pro Ser Val Val Glu Arg Pro Gln Leu Glu Asp 
                 245                250                255
Pro Pro Glu Gln Val Gln Glu Asp Glu Ile Asp Trp Gly Asp Phe Gly 
             260                265                270
Leu Glu Ala Val Ser Asp Ser Gly Asn Ile Ile Ser Ala Glu Thr Pro 
         275                280                285
Gly Ile Asp Trp Gly Ile Ser Leu Glu Ser Glu Ser Lys Asp Ala Gly 
     290                295                300
Ala Asp Lys Ile Asp Trp Gly Asp Asn Ala Val Ala Ser Glu Ile Thr 
 305                310                315                320
Val Leu Glu Thr Gly Thr Glu Ala Pro Glu Gly Val Ala Arg Gly Ser 
                 325                330                335
Asp Ala Leu Thr Leu Leu Glu Tyr Pro Glu Thr Arg Asn Gln Phe Ile 
             340                345                350
Asp Glu Leu Met Glu Leu Glu Ile Phe Leu Ser Gln Arg Ala Val Glu 
         355                360                365
Met Ser Glu Glu Ala Asp Ile Leu Ser Val Ser Gln Phe Gln Leu Ala 
     370                375                380
Pro Ala Ile Leu Gln Gly Gln Thr Lys Glu Lys Met Leu Ser Leu Val 
 385                390                395                400
Ser Thr Leu Gln His Leu Ile Gly Gln Leu Thr Ser Leu Asp Leu Gln 
                 405                410                415
His Leu Phe Met Ile Leu Ala Ser Pro Arg Tyr Val Asp Arg Val Thr 
             420                425                430
Glu Leu Leu Gln Gln Lys Leu Lys Gln Ser Gln Leu Leu Ala Leu Lys 
         435                440                445
Lys Asp Leu Met Val Glu Lys Gln Gln Glu Ala Leu Gln Glu Gln Ala 
     450                455                460
Ala Leu Glu Pro Lys Leu Asp Leu Leu Leu Glu Lys Thr Arg Glu Leu 
 465                470                475                480
Gln Lys Leu Ile Glu Ala Asp Ile Ser Lys Arg Tyr Asn Gly Arg Pro 
                 485                490                495
Val Asn Leu Met Gly Thr Ser Val 
             500



<210> 4477
<211> 568
<212> DNA
<213> Rattus norvegicus
<308> AA799745
<400> 4477

aagccttcc  tgataacca  aagaagcaa  tgtgcctta  gctgagagc  acagagcca  60
tcagacttc  tgcagaggt  acaatgaat  ctggtgcca  cactcaggt  gcccttcct  120
gtggctctg  ctccaggtc  gctggcttc  tgctggtga  gtccagcaa  accagcctg  180
gctgtccca  cccccacca  gaagctggg  ggaggacac  gagggagca  gtcacacag  240
ggtccccat  aggttcaca  gacggccgt  gtatctctt  gagatgtca  cttcaatca  300
cttcttcag  gaggggatc  catagttga  attccgaac  aggaggcta  agagttcca  360
taaataggt  ttgtccttc  catacaggc  tatgatctc  tgccaatcc  tcatccgct  420
tgaagagta  cggccaaaa  tatttttgg  ggaagcctc  gtaccttta  gaaggtcca  480
tattcttag  cagtggaag  agtggatgt  ggaaccaga  agcagctgg  caatctctt  540
gctctctgg  atgtcctgg  tggcggtg  568



<210> 4478
<211> 504
<212> PRT
<213> Rattus norvegicus
<308> AAF60222
<400> 4478

Met Gln Asp His Gln His Val Pro Ile Asp Ile Gln Thr Ser Lys Leu 
  1               5                  10                  15
Leu Asp Trp Leu Val Asp Arg Arg His Cys Asn Leu Lys Trp Gln Ser 
             20                  25                  30
Leu Val Leu Thr Ile Arg Glu Lys Ile Asn Thr Ala Ile Gln Asp Met 
         35                  40                  45
Pro Glu Ser Gln Glu Ile Ala Gln Leu Leu Ser Gly Ser Tyr Ile His 
     50                  55                  60
Tyr Phe His Cys Leu Arg Ile Val Asp Leu Leu Lys Gly Thr Glu Ala 
 65                  70                  75                  80
Ser Thr Lys Asn Ile Phe Gly Arg Tyr Ser Ser Gln Arg Met Lys Asp 
                 85                  90                  95
Trp Gln Glu Ile Ile Ser Leu Tyr Glu Lys Asp Asn Thr Tyr Leu Val 
             100                105                110
Glu Leu Ser Ser Leu Leu Val Arg Asn Val Asn Tyr Glu Ile Pro Ser 
         115                120                125
Leu Lys Lys Gln Ile Ala Lys Cys Gln Gln Leu Gln Gln Asp Tyr Ser 
     130                135                140
Arg Lys Glu Glu Glu Gly Gln Ala Gly Ala Ala Glu Met Arg Glu Gln 
 145                150                155                160
Phe Tyr His Ser Cys Lys Gln Tyr Gly Ile Thr Gly Asp Asn Val Arg 
                 165                170                175
Arg Glu Leu Leu Ala Leu Val Lys Asp Leu Pro Ser Gln Leu Ala Glu 
             180                185                190
Ile Gly Ala Gly Ala Gln Ser Leu Gly Glu Ala Ile Asp Leu Tyr Gln 
         195                200                205
Ala Cys Val Glu Phe Val Cys Asp Ser Pro Thr Glu Gln Val Leu Pro 
     210                215                220
Met Leu Arg Tyr Val Gln Pro Lys Gly Asn Ser Thr Val Tyr Glu Trp 
 225                230                235                240
Arg Thr Gly Thr Glu Pro Ser Val Val Glu Arg Pro Gln Leu Glu Asp 
                 245                250                255
Pro Pro Glu Gln Val Gln Glu Asp Glu Ile Asp Trp Gly Asp Phe Gly 
             260                265                270
Leu Glu Ala Val Ser Asp Ser Gly Asn Ile Ile Ser Ala Glu Thr Pro 
         275                280                285
Gly Ile Asp Trp Gly Ile Ser Leu Glu Ser Glu Ser Lys Asp Ala Gly 
     290                295                300
Ala Asp Lys Ile Asp Trp Gly Asp Asn Ala Val Ala Ser Glu Ile Thr 
 305                310                315                320
Val Leu Glu Thr Gly Thr Glu Ala Pro Glu Gly Val Ala Arg Gly Ser 
                 325                330                335
Asp Ala Leu Thr Leu Leu Glu Tyr Pro Glu Thr Arg Asn Gln Phe Ile 
             340                345                350
Asp Glu Leu Met Glu Leu Glu Ile Phe Leu Ser Gln Arg Ala Val Glu 
         355                360                365
Met Ser Glu Glu Ala Asp Ile Leu Ser Val Ser Gln Phe Gln Leu Ala 
     370                375                380
Pro Ala Ile Leu Gln Gly Gln Thr Lys Glu Lys Met Leu Ser Leu Val 
 385                390                395                400
Ser Thr Leu Gln His Leu Ile Gly Gln Leu Thr Ser Leu Asp Leu Gln 
                 405                410                415
His Leu Phe Met Ile Leu Ala Ser Pro Arg Tyr Val Asp Arg Val Thr 
             420                425                430
Glu Leu Leu Gln Gln Lys Leu Lys Gln Ser Gln Leu Leu Ala Leu Lys 
         435                440                445
Lys Asp Leu Met Val Glu Lys Gln Gln Glu Ala Leu Gln Glu Gln Ala 
     450                455                460
Ala Leu Glu Pro Lys Leu Asp Leu Leu Leu Glu Lys Thr Arg Glu Leu 
 465                470                475                480
Gln Lys Leu Ile Glu Ala Asp Ile Ser Lys Arg Tyr Asn Gly Arg Pro 
                 485                490                495
Val Asn Leu Met Gly Thr Ser Val 
             500



<210> 4479
<211> 568
<212> DNA
<213> Rattus norvegicus
<308> AA799745
<400> 4479

aagccttcc  tgataacca  aagaagcaa  tgtgcctta  gctgagagc  acagagcca  60
tcagacttc  tgcagaggt  acaatgaat  ctggtgcca  cactcaggt  gcccttcct  120
gtggctctg  ctccaggtc  gctggcttc  tgctggtga  gtccagcaa  accagcctg  180
gctgtccca  cccccacca  gaagctggg  ggaggacac  gagggagca  gtcacacag  240
ggtccccat  aggttcaca  gacggccgt  gtatctctt  gagatgtca  cttcaatca  300
cttcttcag  gaggggatc  catagttga  attccgaac  aggaggcta  agagttcca  360
taaataggt  ttgtccttc  catacaggc  tatgatctc  tgccaatcc  tcatccgct  420
tgaagagta  cggccaaaa  tatttttgg  ggaagcctc  gtaccttta  gaaggtcca  480
tattcttag  cagtggaag  agtggatgt  ggaaccaga  agcagctgg  caatctctt  540
gctctctgg  atgtcctgg  tggcggtg  568



<210> 4480
<211> 504
<212> PRT
<213> Rattus norvegicus
<308> AAF60222
<400> 4480

Met Gln Asp His Gln His Val Pro Ile Asp Ile Gln Thr Ser Lys Leu 
  1               5                  10                  15
Leu Asp Trp Leu Val Asp Arg Arg His Cys Asn Leu Lys Trp Gln Ser 
             20                  25                  30
Leu Val Leu Thr Ile Arg Glu Lys Ile Asn Thr Ala Ile Gln Asp Met 
         35                  40                  45
Pro Glu Ser Gln Glu Ile Ala Gln Leu Leu Ser Gly Ser Tyr Ile His 
     50                  55                  60
Tyr Phe His Cys Leu Arg Ile Val Asp Leu Leu Lys Gly Thr Glu Ala 
 65                  70                  75                  80
Ser Thr Lys Asn Ile Phe Gly Arg Tyr Ser Ser Gln Arg Met Lys Asp 
                 85                  90                  95
Trp Gln Glu Ile Ile Ser Leu Tyr Glu Lys Asp Asn Thr Tyr Leu Val 
             100                105                110
Glu Leu Ser Ser Leu Leu Val Arg Asn Val Asn Tyr Glu Ile Pro Ser 
         115                120                125
Leu Lys Lys Gln Ile Ala Lys Cys Gln Gln Leu Gln Gln Asp Tyr Ser 
     130                135                140
Arg Lys Glu Glu Glu Gly Gln Ala Gly Ala Ala Glu Met Arg Glu Gln 
 145                150                155                160
Phe Tyr His Ser Cys Lys Gln Tyr Gly Ile Thr Gly Asp Asn Val Arg 
                 165                170                175
Arg Glu Leu Leu Ala Leu Val Lys Asp Leu Pro Ser Gln Leu Ala Glu 
             180                185                190
Ile Gly Ala Gly Ala Gln Ser Leu Gly Glu Ala Ile Asp Leu Tyr Gln 
         195                200                205
Ala Cys Val Glu Phe Val Cys Asp Ser Pro Thr Glu Gln Val Leu Pro 
     210                215                220
Met Leu Arg Tyr Val Gln Pro Lys Gly Asn Ser Thr Val Tyr Glu Trp 
 225                230                235                240
Arg Thr Gly Thr Glu Pro Ser Val Val Glu Arg Pro Gln Leu Glu Asp 
                 245                250                255
Pro Pro Glu Gln Val Gln Glu Asp Glu Ile Asp Trp Gly Asp Phe Gly 
             260                265                270
Leu Glu Ala Val Ser Asp Ser Gly Asn Ile Ile Ser Ala Glu Thr Pro 
         275                280                285
Gly Ile Asp Trp Gly Ile Ser Leu Glu Ser Glu Ser Lys Asp Ala Gly 
     290                295                300
Ala Asp Lys Ile Asp Trp Gly Asp Asn Ala Val Ala Ser Glu Ile Thr 
 305                310                315                320
Val Leu Glu Thr Gly Thr Glu Ala Pro Glu Gly Val Ala Arg Gly Ser 
                 325                330                335
Asp Ala Leu Thr Leu Leu Glu Tyr Pro Glu Thr Arg Asn Gln Phe Ile 
             340                345                350
Asp Glu Leu Met Glu Leu Glu Ile Phe Leu Ser Gln Arg Ala Val Glu 
         355                360                365
Met Ser Glu Glu Ala Asp Ile Leu Ser Val Ser Gln Phe Gln Leu Ala 
     370                375                380
Pro Ala Ile Leu Gln Gly Gln Thr Lys Glu Lys Met Leu Ser Leu Val 
 385                390                395                400
Ser Thr Leu Gln His Leu Ile Gly Gln Leu Thr Ser Leu Asp Leu Gln 
                 405                410                415
His Leu Phe Met Ile Leu Ala Ser Pro Arg Tyr Val Asp Arg Val Thr 
             420                425                430
Glu Leu Leu Gln Gln Lys Leu Lys Gln Ser Gln Leu Leu Ala Leu Lys 
         435                440                445
Lys Asp Leu Met Val Glu Lys Gln Gln Glu Ala Leu Gln Glu Gln Ala 
     450                455                460
Ala Leu Glu Pro Lys Leu Asp Leu Leu Leu Glu Lys Thr Arg Glu Leu 
 465                470                475                480
Gln Lys Leu Ile Glu Ala Asp Ile Ser Lys Arg Tyr Asn Gly Arg Pro 
                 485                490                495
Val Asn Leu Met Gly Thr Ser Val 
             500



<210> 4481
<211> 568
<212> DNA
<213> Rattus norvegicus
<308> AA799745
<400> 4481

aagccttcc  tgataacca  aagaagcaa  tgtgcctta  gctgagagc  acagagcca  60
tcagacttc  tgcagaggt  acaatgaat  ctggtgcca  cactcaggt  gcccttcct  120
gtggctctg  ctccaggtc  gctggcttc  tgctggtga  gtccagcaa  accagcctg  180
gctgtccca  cccccacca  gaagctggg  ggaggacac  gagggagca  gtcacacag  240
ggtccccat  aggttcaca  gacggccgt  gtatctctt  gagatgtca  cttcaatca  300
cttcttcag  gaggggatc  catagttga  attccgaac  aggaggcta  agagttcca  360
taaataggt  ttgtccttc  catacaggc  tatgatctc  tgccaatcc  tcatccgct  420
tgaagagta  cggccaaaa  tatttttgg  ggaagcctc  gtaccttta  gaaggtcca  480
tattcttag  cagtggaag  agtggatgt  ggaaccaga  agcagctgg  caatctctt  540
gctctctgg  atgtcctgg  tggcggtg  568



<210> 4482
<211> 504
<212> PRT
<213> Rattus norvegicus
<308> AAF60222
<400> 4482

Met Gln Asp His Gln His Val Pro Ile Asp Ile Gln Thr Ser Lys Leu 
  1               5                  10                  15
Leu Asp Trp Leu Val Asp Arg Arg His Cys Asn Leu Lys Trp Gln Ser 
             20                  25                  30
Leu Val Leu Thr Ile Arg Glu Lys Ile Asn Thr Ala Ile Gln Asp Met 
         35                  40                  45
Pro Glu Ser Gln Glu Ile Ala Gln Leu Leu Ser Gly Ser Tyr Ile His 
     50                  55                  60
Tyr Phe His Cys Leu Arg Ile Val Asp Leu Leu Lys Gly Thr Glu Ala 
 65                  70                  75                  80
Ser Thr Lys Asn Ile Phe Gly Arg Tyr Ser Ser Gln Arg Met Lys Asp 
                 85                  90                  95
Trp Gln Glu Ile Ile Ser Leu Tyr Glu Lys Asp Asn Thr Tyr Leu Val 
             100                105                110
Glu Leu Ser Ser Leu Leu Val Arg Asn Val Asn Tyr Glu Ile Pro Ser 
         115                120                125
Leu Lys Lys Gln Ile Ala Lys Cys Gln Gln Leu Gln Gln Asp Tyr Ser 
     130                135                140
Arg Lys Glu Glu Glu Gly Gln Ala Gly Ala Ala Glu Met Arg Glu Gln 
 145                150                155                160
Phe Tyr His Ser Cys Lys Gln Tyr Gly Ile Thr Gly Asp Asn Val Arg 
                 165                170                175
Arg Glu Leu Leu Ala Leu Val Lys Asp Leu Pro Ser Gln Leu Ala Glu 
             180                185                190
Ile Gly Ala Gly Ala Gln Ser Leu Gly Glu Ala Ile Asp Leu Tyr Gln 
         195                200                205
Ala Cys Val Glu Phe Val Cys Asp Ser Pro Thr Glu Gln Val Leu Pro 
     210                215                220
Met Leu Arg Tyr Val Gln Pro Lys Gly Asn Ser Thr Val Tyr Glu Trp 
 225                230                235                240
Arg Thr Gly Thr Glu Pro Ser Val Val Glu Arg Pro Gln Leu Glu Asp 
                 245                250                255
Pro Pro Glu Gln Val Gln Glu Asp Glu Ile Asp Trp Gly Asp Phe Gly 
             260                265                270
Leu Glu Ala Val Ser Asp Ser Gly Asn Ile Ile Ser Ala Glu Thr Pro 
         275                280                285
Gly Ile Asp Trp Gly Ile Ser Leu Glu Ser Glu Ser Lys Asp Ala Gly 
     290                295                300
Ala Asp Lys Ile Asp Trp Gly Asp Asn Ala Val Ala Ser Glu Ile Thr 
 305                310                315                320
Val Leu Glu Thr Gly Thr Glu Ala Pro Glu Gly Val Ala Arg Gly Ser 
                 325                330                335
Asp Ala Leu Thr Leu Leu Glu Tyr Pro Glu Thr Arg Asn Gln Phe Ile 
             340                345                350
Asp Glu Leu Met Glu Leu Glu Ile Phe Leu Ser Gln Arg Ala Val Glu 
         355                360                365
Met Ser Glu Glu Ala Asp Ile Leu Ser Val Ser Gln Phe Gln Leu Ala 
     370                375                380
Pro Ala Ile Leu Gln Gly Gln Thr Lys Glu Lys Met Leu Ser Leu Val 
 385                390                395                400
Ser Thr Leu Gln His Leu Ile Gly Gln Leu Thr Ser Leu Asp Leu Gln 
                 405                410                415
His Leu Phe Met Ile Leu Ala Ser Pro Arg Tyr Val Asp Arg Val Thr 
             420                425                430
Glu Leu Leu Gln Gln Lys Leu Lys Gln Ser Gln Leu Leu Ala Leu Lys 
         435                440                445
Lys Asp Leu Met Val Glu Lys Gln Gln Glu Ala Leu Gln Glu Gln Ala 
     450                455                460
Ala Leu Glu Pro Lys Leu Asp Leu Leu Leu Glu Lys Thr Arg Glu Leu 
 465                470                475                480
Gln Lys Leu Ile Glu Ala Asp Ile Ser Lys Arg Tyr Asn Gly Arg Pro 
                 485                490                495
Val Asn Leu Met Gly Thr Ser Val 
             500



<210> 4483
<211> 671
<212> DNA
<213> Rattus norvegicus
<308> AA799751
<400> 4483

acacctaat  catgaaaag  actctgaat  gaaatccag  catctagaa  taattctgg  60
cataaaatg  acaattatc  catgtgtcc  aagtctgct  agtttgctc  gaagtttgt  120
tttactcca  tatctagaa  gtctcagga  cacatgctg  tactacaca  aacagaagg  180
agctgagca  aaccacacg  aaatgcaaa  ttaagaact  tatggtatt  ctctggtgc  240
ttatgtctt  agcactgac  agagagtta  gtgtgagct  gaaaagttt  cagagaaat  300
agctgcaga  cttcctacc  cacccctag  ttattcaga  caaggaggg  tgatgtggg  360
gatgagaac  tacagactg  acatcctgc  ttcttccta  ctcagtccg  cgctggaca  420
cctggagtg  aaggcacta  aactggcct  agaagtgct  caagcttca  ttcttggtg  480
gcaaaagaa  ttgtggcat  gatcttttg  aacataata  aataactcc  ccctcctct  540
atattctgt  attcacaga  aaaaagaca  ggaggtana  gtttgcaaa  attaaaaaa  600
aggtgaatc  aaatatgaa  aaagtgtgt  tacntattc  gatatggag  accacttag  660
gggcaanag  c  671



<210> 4484
<211> 648
<212> DNA
<213> Homo sapiens
<308> AV724415
<400> 4484

gagggtttt  tagcatctc  ttcaaaaga  gtatgtcag  atttccttt  cacaccaag  60
actggagct  agagcccca  tattctcta  gccaggttc  agtgcctta  actccagaa  120
gtcagatgg  gggtgcaga  gggaagaaa  agaaaagtt  atctcggtg  gtgggttcc  180
atccgcccc  catagcctc  ccttcttcg  aacaatggg  gtggggtag  aagctcttt  240
agtgaaggg  gttctagca  ctcagttaa  actttactc  ccagtcaac  cttgggaca  300
ataaaaatg  cattgtaac  actgtagag  cctgtgact  atcgtttgt  tttgtcagt  360
tgcagttca  cttagccct  ccctgttcc  gtgtagtta  aatctggcc  tgaagacat  420
cgaggcact  cagtaagtg  gatcttttc  agagatcct  ggtgacttt  ggtgcacag  480
gtgaccgag  atttctgcc  ctgtgaatg  ggcactaac  ctgtgcact  tctncacca  540
gcaaggttt  cactgaagt  cttctcatg  tactgggtt  ggtaatgaa  taacacatt  600
taacttaca  aaaaaaaaa  aaannaaaa  aaananaaa  aaaaaaaa  648



<210> 4485
<211> 646
<212> DNA
<213> Rattus norvegicus
<308> AA799764
<400> 4485

caaacttta  ttgatagac  aatcttaca  gataaacaa  gacagctag  caagattac  60
tattaaaaa  aaaatccag  agcgcaaat  taatagact  aatacgttt  tctcctccc  120
aacaggcat  ttgatttaa  aacaaacaa  aacagagtg  acaccacaa  gaaacatag  180
acttacata  tgtcaaata  tctgtagaa  tctgtagga  aggtaaaga  ggttctcag  240
caccaagaa  gcagaacca  ccaccctgg  aggtaaatc  ccagctgat  tgtacacta  300
agcactcct  tccactttt  ggcctatga  gaaggaaat  ggcctgatc  tgactggaa  360
taacttcat  acaaagtct  aagacagag  gaccatcct  ttccaagga  cagggctga  420
caatagcaa  aagcgagag  aagttggta  atgggtgaa  agaaagcct  gccttggca  480
acatctatc  ttcccttcc  ttcttggct  ctggtaaat  aagggccgg  caactgcaa  540
agctcacag  actcctcca  gcacattga  gaggaaaaa  tcctttctg  gtgagatat  600
gcaactttt  tgagacatg  caatgtaac  aagttcatc  ctttgg  646



<210> 4486
<211> 1509
<212> DNA
<213> Homo sapiens
<308> BC007880
<400> 4486

ggcacgagg  ggaagacct  gctggacgc  ctcgggaga  cagacatag  accagaagc  60
actgggaga  gtgttttcg  tccgtgtct  ggccacagt  gtattcact  tttagtctt  120
gagttccgt  agcagtctc  tcacacatt  cttacagtc  ggagtgtac  gactaaatc  180
gtgtaagca  attgaaata  tctttcttt  aggtagcgt  acagtggtt  tttttttcc  240
caggataat  tctatacaa  ttccttact  tcagaggga  cagatcttt  cctcactgt  300
gcaggggcc  tgcaggtgg  taaaggaag  gctggtttc  ggagagtga  tgtaacagc  360
ttgactcga  gctagagat  gagggggtg  ccgtctctt  gacattgga  acctctcag  420
gcctcctga  ggcttcttt  tcttttaga  tctctaccg  tggtcctcc  gcaggttct  480
gctcacaga  atcatcatg  ctttttttc  ctccctgag  cgccttggc  gaagagcgt  540
accctgtga  ccaggcccc  cttagctct  cttcagatc  cagaacaca  acagactcg  600
gagttgctg  acctctttg  tattaagtg  ttgaatcca  ggtgggcct  ttgcaagta  660
cgttagctc  ttttaaatg  tgaactgag  taaggatgc  ctttcttgt  gacatagaa  720
gggcccacg  aaggccctg  gtaggctcc  tagttgctg  tttacctga  gagggccaa  780
gagattaac  ctgcctcgt  gccatgtct  agaaaagtt  ccatatttc  cccagaagg  840
gctcgtttt  ctcttactc  tactttaac  atgtgcctg  aggagccat  ctgggctct  900
gcacttgcc  agcctttct  tgccagggg  agagaaggg  aagggggta  attgagtgt  960
ccaagggcc  tgcaagggc  ggcttgctt  ccacccatc  gctgaggga  ccctctcct  1020
tcgctcctt  cctctgttc  cacctgttg  cttggaaga  gatggtccc  ttgtcttaa  1080
gctttgtga  aaagtcatc  ccagttagg  tctgcacct  tttccttcg  aatagtgcc  1140
ggcggcctt  ctgaagtta  aggtggttg  gagccctct  gcatgcaga  catctggta  1200
attgatctg  caggctggg  ggttctact  ctttctcaa  ttctaagaa  ctttttttt  1260
tcttaaaga  ttctgctga  ttatttgac  atatttgta  gtaccatgt  tccttgtgg  1320
gtatgctct  ttctggttt  tgttttcaa  tcaaatgcc  gtttgggag  agatgaacg  1380
atttagtct  ttagatttg  actgctgga  ttttttttt  aagtgtaac  ttgaatagc  1440
gtcttattg  ttatcctgt  agattagtc  atcgattaa  gtttgataa  taaaaaaaa  1500
aaaaaaaaa  1509



<210> 4487
<211> 567
<212> DNA
<213> Rattus norvegicus
<308> AA799766
<400> 4487

gatgcctga  aattggaca  gtccctttc  gacaacaga  cattatgtt  aatcctgcc  60
gcaagacaa  ctgctcgaa  tcacttaag  agctggagg  cagtgctga  gggggccag  120
ttctcacag  acttaagcc  ccgctgcac  ttggtgggc  ctgccccac  gcttccccc  180
gtctgctgg  gcacggacc  cagcaccac  tctgccaca  tgagctcat  cccaaccaa  240
cacgggctt  tccccaaag  ggagttcat  gagcggaaa  cagccgctt  ttccttact  300
ctcccttct  tcagctgaa  catggcgat  tccacccag  tgtcgatga  ggttaggtg  360
acagcgtta  gcttctgac  aaatagaga  aacaggaag  gtgcgatgt  cccttctcc  420
tcaatgggg  acatcgttt  tacactgaa  ttcatctgt  tcttgggca  gttcttcca  480
atcagagtg  agcccagct  atactcgtg  cgggactgt  ttctagcct  ctccccgaa  540
cacttgaga  gattctcag  tacattc  567



<210> 4488
<211> 1221
<212> DNA
<213> Homo sapiens
<308> NM_006303
<400> 4488

ccgaacgcc  gcagcaggg  cagaaggga  gtggccggt  tccgtcgtg  cctctgacg  60
tttctgagc  ttggccttt  gcacgcgct  caccctttt  ctttggttc  gccatgccg  120
tgtaccagg  aaagcccta  cacgggggc  gcgcgcctc  ccgtgtgga  cttcccacc  180
gcatgtacc  gctccccaa  gtgcacggc  ggagctacg  cccagcgcc  ggcgctggc  240
acgtgcagg  agagtctaa  ctgtctctg  aagctcttg  gtcccgcca  gatgatatt  300
taaaacgtc  gtatgagtt  aaagctgca  ttgatggcc  ctccaagat  attcaaaca  360
cagatgcag  cttggatgt  accaacata  tccaagcgg  tgagcccac  actttaacc  420
ccaatgcgc  ggacttgaa  tcagtgctt  ggaaggatt  cggggcgct  aaagacatc  480
tgatcaacg  aaacccggc  tcccctccc  tctccctgc  tgtgctgca  aggctgctc  540
gtgagcact  cagggtcct  tccacggtg  acacgcact  ctcggtcaa  agcgtgcct  600
aaaaccttc  caagtgctt  ggagaacag  ataaaaaac  gccccgcca  gactatcag  660
tgggattca  tttaatttg  aagaatgtg  cgaagacgc  gatgaaatt  agcatccag  720
cgatgtgcc  catcgaagg  gaagggaac  ttgcacgtt  cttgttctc  ctgtttggc  780
agaagcata  tgctgtcaa  gcaaccctt  tagatagct  ggtagatat  gcgattttt  840
agttaaaag  gggaagcag  aaagaaaaa  ccgctgttt  ccgctccat  aactctgct  900
ttgggaaga  cccttggct  gctgggaat  aactcaccg  agcagacgt  gtgctgtgg  960
ctgtactcc  gcagatcgg  ggctgcagt  tgacagtgc  agccaatgt  cagaggtgg  1020
tgaggtctt  tgaaaacct  gctcctttt  acacggccc  caagctcct  aagtgaatt  1080
ccgtaactg  ttttaaagg  tttagattt  aagaatggt  ctctttcat  cctattatc  1140
gtaagggga  ttgtattag  gtcagagtc  ttttattta  gccagttgt  aagtgtcaa  1200
aaaagcgca  catgtaatt  a  1221



<210> 4489
<211> 320
<212> PRT
<213> Homo sapiens
<308> Q13155
<400> 4489

Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu 
  1               5                  10                  15
Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly 
             20                  25                  30
Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Glu Glu Ser 
         35                  40                  45
Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu Lys 
     50                  55                  60
Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met Ile 
 65                  70                  75                  80
Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp 
                 85                  90                  95
Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu 
             100                105                110
Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro 
         115                120                125
Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu 
     130                135                140
His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser 
 145                150                155                160
Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln 
                 165                170                175
Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val 
             180                185                190
Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu 
         195                200                205
Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys 
     210                215                220
His Asn Ala Val Asn Ala Thr Leu Ile Asp Ser Trp Val Asp Ile Ala 
 225                230                235                240
Ile Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys Ala Ala Val Phe 
                 245                250                255
Arg Ser Met Asn Ser Ala Leu Gly Lys Ser Pro Trp Leu Ala Gly Asn 
             260                265                270
Glu Leu Thr Val Ala Asp Val Val Leu Trp Ser Val Leu Gln Gln Ile 
         275                280                285
Gly Gly Cys Ser Val Thr Val Pro Ala Asn Val Gln Arg Trp Met Arg 
     290                295                300
Ser Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu Lys Leu Leu Lys 
 305                310                315                320



<210> 4490
<211> 631
<212> DNA
<213> Rattus norvegicus
<308> AA799771
<400> 4490

actagacac  tttgataat  atagaatga  tatcttgtc  taaacattc  cagcactat  60
cccttatta  atatgacat  taaaaacaa  atactcatt  tatcattat  aaaggtgtc  120
agtaaaaaa  gaaagattg  cattgaaga  gggactaga  acccctact  aggggcctt  180
aaacggttt  tcacacaca  ctgtgaggt  ggttattat  cacattttg  acaagagaa  240
actacacaa  gttacatac  ttgtgctgc  ataatagca  acagggaat  agatccaat  300
agatccggt  cttagcttt  catttcttt  ctttataaa  tttaaaata  aaagactgc  360
agtaattgc  ttcatttta  aagcataag  aggcagcca  atagtttcc  gggtggctt  420
acaaagtga  acaaatgaa  agaaaatgc  ttcagtgaa  acattccaa  ggtgacgct  480
taaggtctg  tcaagtgga  ccaaaaggc  gaagcaaac  acgtgaccg  ctgtgggac  540
ggtctcagg  aaacggggg  gctgggggc  gcagacttt  aacacacgt  tacggctac  600
ctgcaagta  ttgagaatg  accaggtac  c  631



<210> 4491
<211> 765
<212> DNA
<213> Homo sapiens
<308> BG779035
<400> 4491

taagccaag  tcatgccac  gcatgccag  ctgggtgac  gcacaagac  gtctcaaaa  60
aaaacaaaa  aaggaaaaa  aaaactagc  ccagtccct  tctaaattg  tatagtttt  120
gactattat  tgaattagt  ttatccaaa  ttcatatgc  gattgattt  tcattttgt  180
tgtatatta  atgatataa  tattttcat  gaatatatt  ctaatttac  aacactgaa  240
tattagctt  atagagttt  tcccaaacc  tataaaact  tgaaatgta  ttatgtttg  300
gctttaaaa  ttataaaaa  ttcatttaa  caagttgct  gcatcatta  tagcctttc  360
acctataat  atgatgcat  tgatgccac  gaacagtaa  agcacaaag  acaggtcac  420
cagtctaga  tggattgag  tttaattaa  cttcttcat  catagcctg  taagaatca  480
gctgggtct  gaagagtta  cagactgta  gcctgtatt  attttgcaa  ctaatgtta  540
tggtttact  ccagccttg  atagcaatg  cagttgcag  tgtgactat  atgtgactt  600
tggtaaaaa  ggtttatat  taaagtagg  ttagatttt  ctggaaggt  gtcttgagt  660
tttggacaa  cagggtagg  taaaattca  ttacgtttg  agtgtaatt  aatcctaga  720
tagagcatc  tccagaaaa  aactggaac  agactttgg  gaata  765



<210> 4492
<211> 631
<212> DNA
<213> Rattus norvegicus
<308> AA799771
<400> 4492

actagacac  tttgataat  atagaatga  tatcttgtc  taaacattc  cagcactat  60
cccttatta  atatgacat  taaaaacaa  atactcatt  tatcattat  aaaggtgtc  120
agtaaaaaa  gaaagattg  cattgaaga  gggactaga  acccctact  aggggcctt  180
aaacggttt  tcacacaca  ctgtgaggt  ggttattat  cacattttg  acaagagaa  240
actacacaa  gttacatac  ttgtgctgc  ataatagca  acagggaat  agatccaat  300
agatccggt  cttagcttt  catttcttt  ctttataaa  tttaaaata  aaagactgc  360
agtaattgc  ttcatttta  aagcataag  aggcagcca  atagtttcc  gggtggctt  420
acaaagtga  acaaatgaa  agaaaatgc  ttcagtgaa  acattccaa  ggtgacgct  480
taaggtctg  tcaagtgga  ccaaaaggc  gaagcaaac  acgtgaccg  ctgtgggac  540
ggtctcagg  aaacggggg  gctgggggc  gcagacttt  aacacacgt  tacggctac  600
ctgcaagta  ttgagaatg  accaggtac  c  631



<210> 4493
<211> 765
<212> DNA
<213> Homo sapiens
<308> BG779035
<400> 4493

taagccaag  tcatgccac  gcatgccag  ctgggtgac  gcacaagac  gtctcaaaa  60
aaaacaaaa  aaggaaaaa  aaaactagc  ccagtccct  tctaaattg  tatagtttt  120
gactattat  tgaattagt  ttatccaaa  ttcatatgc  gattgattt  tcattttgt  180
tgtatatta  atgatataa  tattttcat  gaatatatt  ctaatttac  aacactgaa  240
tattagctt  atagagttt  tcccaaacc  tataaaact  tgaaatgta  ttatgtttg  300
gctttaaaa  ttataaaaa  ttcatttaa  caagttgct  gcatcatta  tagcctttc  360
acctataat  atgatgcat  tgatgccac  gaacagtaa  agcacaaag  acaggtcac  420
cagtctaga  tggattgag  tttaattaa  cttcttcat  catagcctg  taagaatca  480
gctgggtct  gaagagtta  cagactgta  gcctgtatt  attttgcaa  ctaatgtta  540
tggtttact  ccagccttg  atagcaatg  cagttgcag  tgtgactat  atgtgactt  600
tggtaaaaa  ggtttatat  taaagtagg  ttagatttt  ctggaaggt  gtcttgagt  660
tttggacaa  cagggtagg  taaaattca  ttacgtttg  agtgtaatt  aatcctaga  720
tagagcatc  tccagaaaa  aactggaac  agactttgg  gaata  765



<210> 4494
<211> 615
<212> DNA
<213> Rattus norvegicus
<308> AA799773
<400> 4494

ccacatgtg  aaaagtttc  cagagagtt  ggccccaca  tgtgtaaaa  agaccccca  60
tggggcaga  ctgtgtaac  ataaaaaaa  aatagtaag  gaaatcagt  tcccaggag  120
cctggcttg  gtggagcat  tcactcagg  ccagtccgc  tgcggtgtg  tgtttgttc  180
ggaactgct  tcttctgat  gttctttct  ttccaagcc  cttactcta  ggctatggc  240
accagacgg  ctgacagag  cctcaggca  ggtggtttg  gaggatgac  tctttcaca  300
acagatacc  caactcagt  cttgcccac  ggcatcagc  ccactatga  ccccagggc  360
tccccccaa  ccgtttaac  ccttatatc  cagtctcgg  ccccagctt  accaagtct  420
ccctcagga  acctttgag  gacactgaa  caaaacaga  aaaggcccg  ccccccacc  480
accaagtgg  acagtgggg  acgggggat  gtatcaccc  gtcacacct  aggcaggtg  540
tttagtgtc  gattctgtg  gtgtggata  gggggtggc  catctgtgt  ggtatgact  600
tggcaggaa  tgggg  615



<210> 4495
<211> 615
<212> DNA
<213> Rattus norvegicus
<308> AA799773
<400> 4495

ccacatgtg  aaaagtttc  cagagagtt  ggccccaca  tgtgtaaaa  agaccccca  60
tggggcaga  ctgtgtaac  ataaaaaaa  aatagtaag  gaaatcagt  tcccaggag  120
cctggcttg  gtggagcat  tcactcagg  ccagtccgc  tgcggtgtg  tgtttgttc  180
ggaactgct  tcttctgat  gttctttct  ttccaagcc  cttactcta  ggctatggc  240
accagacgg  ctgacagag  cctcaggca  ggtggtttg  gaggatgac  tctttcaca  300
acagatacc  caactcagt  cttgcccac  ggcatcagc  ccactatga  ccccagggc  360
tccccccaa  ccgtttaac  ccttatatc  cagtctcgg  ccccagctt  accaagtct  420
ccctcagga  acctttgag  gacactgaa  caaaacaga  aaaggcccg  ccccccacc  480
accaagtgg  acagtgggg  acgggggat  gtatcaccc  gtcacacct  aggcaggtg  540
tttagtgtc  gattctgtg  gtgtggata  gggggtggc  catctgtgt  ggtatgact  600
tggcaggaa  tgggg  615



<210> 4496
<211> 568
<212> DNA
<213> Rattus norvegicus
<308> AA799778
<400> 4496

actcataat  aagcagtgc  atttcagag  atgaaactt  caaattctg  ttcaaacat  60
ttattgtaa  atgttttaa  taattacaa  tttaaacta  aacttggta  tttctgttg  120
gcagcgagt  gctgcaaat  gcttactca  atgtgatca  acaactccg  atacagagc  180
aggatcaga  atagggtta  gccactaaa  ggaccttga  catttctta  gaaaggtac  240
ccacaattt  attagacag  aatacagaa  gagttcttc  agtagagta  ttctcattt  300
agttaaccc  ctctggcta  cacaactga  atagacaca  tcacataat  ggctgagct  360
gagccttct  tgcaagcat  tttagatct  cgatgcact  ggcaatggt  tccttttcc  420
gctgtgcag  aatgctctg  atcacatgc  tctccaccc  gtttatcat  tgctctccc  480
ccttgcgac  catcatgtc  tgtacagaa  tatggtagt  caggcgatt  tttacctcc  540
tatatgctt  atgtagtcg  tcccggta  568



<210> 4497
<211> 256
<212> PRT
<213> Rattus norvegicus
<308> P19511
<400> 4497

Met Leu Ser Arg Val Val Leu Ser Ala Ala Ala Thr Ala Ala Pro Cys 
  1               5                  10                  15
Leu Lys Asn Ala Ala Val Leu Gly Pro Gly Val Leu Gln Ala Thr Arg 
             20                  25                  30
Val Phe His Thr Gly Gln Pro Arg Leu Ala Pro Leu Pro Pro Leu Pro 
         35                  40                  45
Glu Tyr Gly Gly Lys Val Arg Leu Gly Leu Ile Pro Glu Glu Phe Phe 
     50                  55                  60
Gln Phe Leu Tyr Pro Lys Thr Gly Val Thr Gly Pro Tyr Val Leu Gly 
 65                  70                  75                  80
Thr Gly Leu Ser Leu Tyr Phe Leu Ser Lys Glu Ile Tyr Val Ile Thr 
                 85                  90                  95
Pro Glu Thr Phe Ser Thr Ile Ser Val Val Gly Leu Ile Val Tyr Val 
             100                105                110
Ile Lys Lys Tyr Gly Ala Ser Ile Gly Glu Phe Ile Asp Lys Leu Asn 
         115                120                125
Glu Glu Lys Ile Ala Gln Leu Glu Glu Ile Lys Gln Ser Ser Met Lys 
     130                135                140
Gln Ile Gln Asp Ala Ile Asn Arg Glu Lys Ala Gln Gln Ala Leu Val 
 145                150                155                160
Gln Lys Arg His Tyr Leu Phe Asp Val Gln Arg Asn Asn Ile Ala Leu 
                 165                170                175
Ala Leu Glu Val Thr Tyr Arg Glu Arg Leu His Lys Ala Tyr Lys Glu 
             180                185                190
Val Lys Asn Arg Leu Asp Tyr His Ile Ser Val Gln Asp Met Met Arg 
         195                200                205
Arg Lys Glu Gly Glu His Met Ile Asn Trp Val Glu Lys His Val Ile 
     210                215                220
Gln Ser Ile Ser Ala Gln Gln Glu Lys Glu Thr Ile Ala Lys Cys Ile 
 225                230                235                240
Gly Asp Leu Lys Met Leu Ala Lys Lys Ala Gln Ala Gln Pro Ile Met 
                 245                250                255



<210> 4498
<211> 842
<212> DNA
<213> Homo sapiens
<308> BI461802
<400> 4498

agcggatct  cacggttcc  actccaacc  agactcaaa  tggacgccg  ccggagact  60
agctccggc  gcaaacccc  cgtggtgca  ctctgagcc  ccgcccctc  cccgaggga  120
ccgcaactc  acttctcgc  agaattgct  ctatggctc  atcctgctt  ccggctgtc  180
ccctcatgc  ataggctct  agcgttact  gactcttct  gcgataatt  ttttaaaaa  240
tctcccaag  aaagttgaa  gaagagtac  aaattttca  ctcgcgaga  ttgtgagcg  300
ccatcttgg  tctgccctg  cagattctc  tatcggggt  acagggacg  taagattgc  360
acctggact  tcgttgacc  tgctgtccc  ggtggtact  tccgccgcc  ccacagcgg  420
cccctctct  aagaatgca  ccttcctag  tccagggta  tgcaggcaa  aaggacctt  480
catacaggg  agccacacc  tgtccctgt  ccacctctt  ctgaatacg  aggacaagt  540
cgttatgga  tgatccctg  ggaattctt  cagtttctt  atcctaaaa  tggtgtaac  600
ggaccctat  tactcggaa  ctgggctta  ctttgtacg  tttatccaa  gaacatata  660
gtgattagg  gcagagacc  tcactgccc  atncagtac  aaggtgtca  tgtgtctaa  720
gggcattcc  cccaattat  gtccctttg  tgccagact  tgctgataa  ctccaatga  780
caaaaaaat  ggcccaaat  agaagaagg  aagcagggt  ccatccaaa  gatccagaa  840
tc  842



<210> 4499
<211> 256
<212> PRT
<213> Homo sapiens
<308> NP_001679
<400> 4499

Met Leu Ser Arg Val Val Leu Ser Ala Ala Ala Thr Ala Ala Pro Ser 
  1               5                  10                  15
Leu Lys Asn Ala Ala Phe Leu Gly Pro Gly Val Leu Gln Ala Thr Arg 
             20                  25                  30
Thr Phe His Thr Gly Gln Pro His Leu Val Pro Val Pro Pro Leu Pro 
         35                  40                  45
Glu Tyr Gly Gly Lys Val Arg Tyr Gly Leu Ile Pro Glu Glu Phe Phe 
     50                  55                  60
Gln Phe Leu Tyr Pro Lys Thr Gly Val Thr Gly Pro Tyr Val Leu Gly 
 65                  70                  75                  80
Thr Gly Leu Ile Leu Tyr Ala Leu Ser Lys Glu Ile Tyr Val Ile Ser 
                 85                  90                  95
Ala Glu Thr Phe Thr Ala Leu Ser Val Leu Gly Val Met Val Tyr Gly 
             100                105                110
Ile Lys Lys Tyr Gly Pro Phe Val Ala Asp Phe Ala Asp Lys Leu Asn 
         115                120                125
Glu Gln Lys Leu Ala Gln Leu Glu Glu Ala Lys Gln Ala Ser Ile Gln 
     130                135                140
His Ile Gln Asn Ala Ile Asp Thr Glu Lys Ser Gln Gln Ala Leu Val 
 145                150                155                160
Gln Lys Arg His Tyr Leu Phe Asp Val Gln Arg Asn Asn Ile Ala Met 
                 165                170                175
Ala Leu Glu Val Thr Tyr Arg Glu Arg Leu Tyr Arg Val Tyr Lys Glu 
             180                185                190
Val Lys Asn Arg Leu Asp Tyr His Ile Ser Val Gln Asn Met Met Arg 
         195                200                205
Arg Lys Glu Gln Glu His Met Ile Asn Trp Val Glu Lys His Val Val 
     210                215                220
Gln Ser Ile Ser Thr Gln Gln Glu Lys Glu Thr Ile Ala Lys Cys Ile 
 225                230                235                240
Ala Asp Leu Lys Leu Leu Ala Lys Lys Ala Gln Ala Gln Pro Val Met 
                 245                250                255



<210> 4500
<211> 679
<212> DNA
<213> Rattus norvegicus
<308> AA799779
<400> 4500

caagactgc  ttattagac  acacagtga  atgaatgcc  ctggcagcc  tcatggtgg  60
acagtcaca  tgacattcc  atgctctcc  cctcctggc  gaagcacgg  tcacgggtc  120
caaggagac  gacgtcaca  cttcctctc  gcgcccatt  gtggcagag  aagtccttt  180
tgactgtca  tatggaact  tgttttctg  aactgctcc  tgattatca  agttttgca  240
tggctggtt  tcctattgg  ttcttacat  cgagcattt  ttctaactt  cttgtggca  300
gcccgttga  ataatacac  tatttactg  ctaccttat  cttttctac  accccgagt  360
tcacgaagg  tgctaaggc  ttcttctga  gttcagagg  cagcgcgtc  taacactga  420
aggcatctt  atccagaag  tggcgggtg  acttcctgg  tgtgaccaa  tactccttc  480
cactgaagt  gtcctcttc  tgcaagagg  atttggaaa  tatctgata  gattccaca  540
aaggtttaa  gagtcctgt  aggaactgt  atacagcat  ccctttgtc  gtgaggatg  600
tgtccttcc  agtcatctg  ataacctca  ttttacaca  caagtaaca  ccttcctca  660
agtccctga  tgtgtttcc  679



<210> 4501
<211> 678
<212> PRT
<213> Rattus norvegicus
<308> Q9ES71
<400> 4501

Met Asp Val Pro Ser Ser Ser Ser Ser Arg Phe Ser Val Gly Ser Ala 
  1               5                  10                  15
Ser Pro Ser Ser Val Leu Leu Tyr Ala Lys Asp Leu Lys Lys Trp Asp 
             20                  25                  30
Glu Phe Glu Asp Leu Leu Glu Glu Arg Arg Gln Val Ser Asp Phe Lys 
         35                  40                  45
Phe Ala Met Lys Cys Tyr Thr Pro Pro Leu Tyr Arg Gly Ile Thr Pro 
     50                  55                  60
Cys Lys Pro Ser Asp Ile Lys Ser Ile Val Leu Asn Ser Glu Glu Ile 
 65                  70                  75                  80
Asn Tyr Val Ile Lys Gln Leu Ser Arg Glu Ser Leu Thr Gly Val Asp 
                 85                  90                  95
Val Leu Arg Glu Glu Ala Asn Glu Ile Leu Glu Glu Met Ser His Lys 
             100                105                110
Leu Arg Ile Gly Ala Ile Arg Phe Phe Ala Phe Val Leu Ser Lys Val 
         115                120                125
Phe Lys Gln Ile Phe Ser Lys Val Cys Val Asn Glu Glu Gly Ile Gln 
     130                135                140
Lys Leu Gln Arg Ala Ile Gln Glu His Pro Val Ile Leu Leu Pro Ser 
 145                150                155                160
His Arg Ser Tyr Ile Asp Phe Leu Met Leu Ser Phe Val Leu Tyr Asn 
                 165                170                175
Tyr Asp Leu Pro Val Pro Val Ile Ala Ala Gly Met Asp Phe Leu Gly 
             180                185                190
Met Arg Val Val Ser Glu Leu Leu Arg Met Ser Gly Ala Phe Phe Met 
         195                200                205
Arg Arg Thr Phe Gly Gly Asn Lys Leu Tyr Trp Ala Val Phe Ser Glu 
     210                215                220
Tyr Val Lys Thr Met Leu Arg Ser Gly Tyr Ala Pro Val Glu Phe Phe 
 225                230                235                240
Leu Glu Gly Thr Arg Ser Arg Ala Ala Lys Thr Leu Thr Pro Lys Phe 
                 245                250                255
Gly Leu Leu Asn Ile Val Met Glu Pro Phe Phe Lys Arg Glu Val Phe 
             260                265                270
Asp Thr Tyr Phe Val Pro Ile Ser Ile Ser Tyr Asp Lys Ile Leu Glu 
         275                280                285
Glu Ser Leu Tyr Ala Tyr Glu Leu Leu Gly Ile Pro Lys Pro Lys Glu 
     290                295                300
Ser Thr Thr Gly Leu Leu Lys Ala Arg Arg Ile Leu Ser Glu Asn Phe 
 305                310                315                320
Gly Ser Ile His Val Tyr Phe Gly Asp Pro Val Ser Leu Arg Ser Leu 
                 325                330                335
Ala Ala Gly Arg Leu Ser Arg Asn Thr Tyr Asn Leu Val Pro Arg Cys 
             340                345                350
Ile Pro Gln Lys Gln Pro Glu Asp Val Gln Ala Phe Val Thr Glu Val 
         355                360                365
Ala Tyr Lys Met Gln Leu Leu Gln Ile Glu Asn Leu Ala Leu Ser Pro 
     370                375                380
Trp Leu Leu Val Val Ala Ile Leu Leu Gln Asn Gln Leu Cys Met Asp 
 385                390                395                400
Phe Asp Ala Leu Val Glu Lys Thr Leu Trp Leu Lys Gly Leu Thr Gln 
                 405                410                415
Val Phe Gly Gly Phe Leu Leu Trp Pro Asp Asn Lys Leu Pro Glu Glu 
             420                425                430
Val Val Gln Ser Ser Ile Leu Leu His Ser Asn Leu Ala Thr Leu Val 
         435                440                445
Lys Asp Gln Val Val Leu Lys Val Asp Ser Glu Ser Ser Gln Met Val 
     450                455                460
Asn Gly Leu Val Pro Gln His Ile Ala Phe Leu Met Cys Ser Ala Tyr 
 465                470                475                480
Arg Asn Gln Leu Leu Asn Val Phe Ala Arg Pro Ser Leu Val Ala Val 
                 485                490                495
Ala Leu His Met Thr Pro Gly Leu Arg Lys Glu Asp Val Phe Ser Cys 
             500                505                510
Phe Ser Phe Leu Arg Asn Val Phe Ser Asp Glu Phe Ile Phe Leu Pro 
         515                520                525
Gly Asn Thr Leu Arg Asp Phe Glu Glu Gly Cys Tyr Leu Leu Cys Lys 
     530                535                540
Thr Glu Val Met Gln Met Thr Gly Lys Asp Ile Ile Leu Thr Asp Lys 
 545                550                555                560
Gly Asn Ala Val Leu Gln Phe Leu Thr Gly Leu Phe Lys Pro Phe Val 
                 565                570                575
Glu Ser Tyr Gln Ile Leu Ser Lys Cys Leu Leu His Glu Glu Asp Tyr 
             580                585                590
Phe Ser Glu Lys Glu Tyr Leu Val Thr Ala Arg Lys Phe Thr Arg Gln 
         595                600                605
Leu Leu Asp Gln Asp Ala Ser Gln Cys Tyr Asp Ala Leu Ser Ser Glu 
     610                615                620
Leu Gln Lys Asn Ala Leu Ala Ala Phe Val Arg Leu Gly Val Val Glu 
 625                630                635                640
Lys Asn Lys Val Asp Ser Lys Tyr Val Tyr Tyr Val Asn Gly Pro Ala 
                 645                650                655
Thr Ser Lys Leu Glu Glu Met Leu Gly Cys Lys Lys Pro Ile Gly Lys 
             660                665                670
Pro Ala Thr Ala Lys Leu 
         675



<210> 4502
<211> 2470
<212> DNA
<213> Homo sapiens
<308> NM_014236
<400> 4502

gaattcggc  cgagccggg  tcctgtgta  cggctgcag  gggtgccgc  gccctaggc  60
aagtagggc  gtcctgagc  aaagaaccg  ccccagcag  agcaccacc  cggcttagc  120
aagaatccc  gaccccgcc  gggaaggca  ccgcaccat  gagtcttcc  gttcatcta  180
ctcttattt  tccgttggc  caaccagtc  cagcgctgt  gtgctcctc  actcgaagg  240
gctcaaaaa  tgggatgag  ttgaagata  tttagaaga  aggaggcat  tcagtgact  300
gaaatttgc  atgaaatgc  acacacctc  tgtctataa  ggaattact  catgtaaac  360
aattgatat  aaatgtagt  ttctcaatt  tgaggagat  cattatgtc  ttaaacagc  420
ttccaagga  tcccttcaa  ctgtggatg  cctccgaga  gaagtgagt  agatcttag  480
tgaaatgag  cacaaactg  gtcttggag  cattcggtt  tgtgccttc  ccctgagca  540
agtatttaa  caaattttc  cgaaggtgt  tgtaaatga  gaaggtatt  agaaactac  600
aagagccat  caggagcat  ctgttgttc  gctgcctag  catcgaagt  acattgact  660
cctcatgtt  tcttttctt  tatacaatt  tgatttgcc  gtgccagtt  tagcagcag  720
aatggactt  ctgggaatg  aaatggttg  tgagctgct  cgaatgtcg  gtgcctttt  780
catgcggcg  acctttggt  gcaataaac  ctactgggc  gtattctct  aatatgtaa  840
aactatgtt  cggaatggt  atgctcctg  tgaattttt  ctcgaaggg  caagaagcc  900
ctctgccaa  acattgact  ctaaatttg  tcttctgaa  attgtgatg  agccatttt  960
taaaagaga  gtttttgat  cctaccttg  cccaattag  atcagttat  ataagatct  1020
ggaagaaac  ctttatgtg  atgagcttc  aggggttcc  aaaccaaaa  agtctacaa  1080
tgggttgct  aaagccaga  agattctct  tgaaaattt  ggaagcatc  atgtgtact  1140
tggagatcc  gtgtcactt  gatctttgg  agctgggag  atgagtcgg  gctcatata  1200
cttggttcc  agatacatt  ctcagaaac  gtctgagga  atgcatgcc  ttgtcactg  1260
agttgccta  aaaatggag  ttctgcaaa  tgaaaacat  gttttgagc  cctggaccc  1320
aatagttgc  gttctgctt  agaaccggc  atccatgga  tttgatgct  tggtggaaa  1380
gactttatg  ctaaaaggc  taacccagg  atttggagg  tttctcatt  ggcctgata  1440
taaacctgc  gaagaagtt  tcccggcca  cattcttct  cattccaac  ttgccagcc  1500
tgtcaaaga  caggtgatt  tgaaagtgg  ctccggaga  tcggaagtg  tcgatgggc  1560
tatgctcca  cacatcact  tcctcatgt  ctcagctta  aggaaccag  tgctcaaca  1620
ttttgtgcg  ccatcctta  tagcagtag  attgcagat  acaccaggg  tcaggaaag  1680
ggatgtcta  agttgcttt  gcttcctac  tgatgtttt  gcagatgag  tcatcttcc  1740
tccaggaaa  acactaaag  actttgaag  aggctgtta  ctgctttgt  aaagtgaag  1800
catacaagt  actacgaaa  acatcctag  tacagagaa  ggaaatact  tgttagaat  1860
tttagtagg  ctctttaaa  cttttgtgg  aagctatca  ataatttgc  agtaccttt  1920
gagtgaaga  gaggaccac  tcagtgagg  acagtactt  gctgcagtc  gaaaattca  1980
aagtcagct  ctcgatcaa  gtacctctc  atgttatga  gtattatct  ctgatgtgc  2040
gaaaaacgc  ttagcagcc  gtgtgaggc  cggagtagt  gagaagaag  agataaata  2100
taactgtat  tttaatgtg  atgaacctg  cacaaccaa  ttagaagaa  tgcttggtt  2160
taagacacc  ataggaaaa  cagccactg  aaaacttta  taatcaaca  atagttatg  2220
aaaattcgg  cacgtaatt  ctctcatcg  aggactcat  acaacaaac  gggaagtaa  2280
ggaagagac  catcctctc  tactccctg  gactctgag  acagtggac  cagagggaa  2340
agatgatca  tggaagcaa  cagtttact  ttccccacc  cagtggtta  aaggcgttt  2400
tatctgaca  tatgtgtgt  ttttaaaat  aacttttgg  aacatgaaa  aaaaaaaaa  2460
aaaactcgag  2470



<210> 4503
<211> 680
<212> PRT
<213> Homo sapiens
<308> O15228
<400> 4503

Met Glu Ser Ser Ser Ser Ser Asn Ser Tyr Phe Ser Val Gly Pro Thr 
  1               5                  10                  15
Ser Pro Ser Ala Val Val Leu Leu Tyr Ser Lys Glu Leu Lys Lys Trp 
             20                  25                  30
Asp Glu Phe Glu Asp Ile Leu Glu Glu Arg Arg His Val Ser Asp Leu 
         35                  40                  45
Lys Phe Ala Met Lys Cys Tyr Thr Pro Leu Val Tyr Lys Gly Ile Thr 
     50                  55                  60
Pro Cys Lys Pro Ile Asp Ile Lys Cys Ser Val Leu Asn Ser Glu Glu 
 65                  70                  75                  80
Ile His Tyr Val Ile Lys Gln Leu Ser Lys Glu Ser Leu Gln Ser Val 
                 85                  90                  95
Asp Val Leu Arg Glu Glu Val Ser Glu Ile Leu Asp Glu Met Ser His 
             100                105                110
Lys Leu Arg Leu Gly Ala Ile Arg Phe Cys Ala Phe Thr Leu Ser Lys 
         115                120                125
Val Phe Lys Gln Ile Phe Ser Lys Val Cys Val Asn Glu Glu Gly Ile 
     130                135                140
Gln Lys Leu Gln Arg Ala Ile Gln Glu His Pro Val Val Leu Leu Pro 
 145                150                155                160
Ser His Arg Ser Tyr Ile Asp Phe Leu Met Leu Ser Phe Leu Leu Tyr 
                 165                170                175
Asn Tyr Asp Leu Pro Val Pro Val Ile Ala Ala Gly Met Asp Phe Leu 
             180                185                190
Gly Met Lys Met Val Gly Glu Leu Leu Arg Met Ser Gly Ala Phe Phe 
         195                200                205
Met Arg Arg Thr Phe Gly Gly Asn Lys Leu Tyr Trp Ala Val Phe Ser 
     210                215                220
Glu Tyr Val Lys Thr Met Leu Arg Asn Gly Tyr Ala Pro Val Glu Phe 
 225                230                235                240
Phe Leu Glu Gly Thr Arg Ser Arg Ser Ala Lys Thr Leu Thr Pro Lys 
                 245                250                255
Phe Gly Leu Leu Asn Ile Val Met Glu Pro Phe Phe Lys Arg Glu Val 
             260                265                270
Phe Asp Thr Tyr Leu Val Pro Ile Ser Ile Ser Tyr Asp Lys Ile Leu 
         275                280                285
Glu Glu Thr Leu Tyr Val Tyr Glu Leu Leu Gly Val Pro Lys Pro Lys 
     290                295                300
Glu Ser Thr Thr Gly Leu Leu Lys Ala Arg Lys Ile Leu Ser Glu Asn 
 305                310                315                320
Phe Gly Ser Ile His Val Tyr Phe Gly Asp Pro Val Ser Leu Arg Ser 
                 325                330                335
Leu Ala Ala Gly Arg Met Ser Arg Ser Ser Tyr Asn Leu Val Pro Arg 
             340                345                350
Tyr Ile Pro Gln Lys Gln Ser Glu Asp Met His Ala Phe Val Thr Glu 
         355                360                365
Val Ala Tyr Lys Met Glu Leu Leu Gln Ile Glu Asn Met Val Leu Ser 
     370                375                380
Pro Trp Thr Leu Ile Val Ala Val Leu Leu Gln Asn Arg Pro Ser Met 
 385                390                395                400
Asp Phe Asp Ala Leu Val Glu Lys Thr Leu Trp Leu Lys Gly Leu Thr 
                 405                410                415
Gln Ala Phe Gly Gly Phe Leu Ile Trp Pro Asp Asn Lys Pro Ala Glu 
             420                425                430
Glu Val Val Pro Ala Ser Ile Leu Leu His Ser Asn Ile Ala Ser Leu 
         435                440                445
Val Lys Asp Gln Val Ile Leu Lys Val Asp Ser Gly Asp Ser Glu Val 
     450                455                460
Val Asp Gly Leu Met Leu Gln His Ile Thr Leu Leu Met Cys Ser Ala 
 465                470                475                480
Tyr Arg Asn Gln Leu Leu Asn Ile Phe Val Arg Pro Ser Leu Val Ala 
                 485                490                495
Val Ala Leu Gln Met Thr Pro Gly Phe Arg Lys Glu Asp Val Tyr Ser 
             500                505                510
Cys Phe Arg Phe Leu Arg Asp Val Phe Ala Asp Glu Phe Ile Phe Leu 
         515                520                525
Pro Gly Asn Thr Leu Lys Asp Phe Glu Glu Gly Cys Tyr Leu Leu Cys 
     530                535                540
Lys Ser Glu Ala Ile Gln Val Thr Thr Lys Asp Ile Leu Val Thr Glu 
 545                550                555                560
Lys Gly Asn Thr Val Leu Glu Phe Leu Val Gly Leu Phe Lys Pro Phe 
                 565                570                575
Val Glu Ser Tyr Gln Ile Ile Cys Lys Tyr Leu Leu Ser Glu Glu Glu 
             580                585                590
Asp His Phe Ser Glu Glu Gln Tyr Leu Ala Ala Val Arg Lys Phe Thr 
         595                600                605
Ser Gln Leu Leu Asp Gln Gly Thr Ser Gln Cys Tyr Asp Val Leu Ser 
     610                615                620
Ser Asp Val Gln Lys Asn Ala Leu Ala Ala Cys Val Arg Leu Gly Val 
 625                630                635                640
Val Glu Lys Lys Lys Ile Asn Asn Asn Cys Ile Phe Asn Val Asn Glu 
                 645                650                655
Pro Ala Thr Thr Lys Leu Glu Glu Met Leu Gly Cys Lys Thr Pro Ile 
             660                665                670
Gly Lys Pro Ala Thr Ala Lys Leu 
         675                680



<210> 4504
<211> 679
<212> DNA
<213> Rattus norvegicus
<308> AA799779
<400> 4504

caagactgc  ttattagac  acacagtga  atgaatgcc  ctggcagcc  tcatggtgg  60
acagtcaca  tgacattcc  atgctctcc  cctcctggc  gaagcacgg  tcacgggtc  120
caaggagac  gacgtcaca  cttcctctc  gcgcccatt  gtggcagag  aagtccttt  180
tgactgtca  tatggaact  tgttttctg  aactgctcc  tgattatca  agttttgca  240
tggctggtt  tcctattgg  ttcttacat  cgagcattt  ttctaactt  cttgtggca  300
gcccgttga  ataatacac  tatttactg  ctaccttat  cttttctac  accccgagt  360
tcacgaagg  tgctaaggc  ttcttctga  gttcagagg  cagcgcgtc  taacactga  420
aggcatctt  atccagaag  tggcgggtg  acttcctgg  tgtgaccaa  tactccttc  480
cactgaagt  gtcctcttc  tgcaagagg  atttggaaa  tatctgata  gattccaca  540
aaggtttaa  gagtcctgt  aggaactgt  atacagcat  ccctttgtc  gtgaggatg  600
tgtccttcc  agtcatctg  ataacctca  ttttacaca  caagtaaca  ccttcctca  660
agtccctga  tgtgtttcc  679



<210> 4505
<211> 678
<212> PRT
<213> Rattus norvegicus
<308> Q9ES71
<400> 4505

Met Asp Val Pro Ser Ser Ser Ser Ser Arg Phe Ser Val Gly Ser Ala 
  1               5                  10                  15
Ser Pro Ser Ser Val Leu Leu Tyr Ala Lys Asp Leu Lys Lys Trp Asp 
             20                  25                  30
Glu Phe Glu Asp Leu Leu Glu Glu Arg Arg Gln Val Ser Asp Phe Lys 
         35                  40                  45
Phe Ala Met Lys Cys Tyr Thr Pro Pro Leu Tyr Arg Gly Ile Thr Pro 
     50                  55                  60
Cys Lys Pro Ser Asp Ile Lys Ser Ile Val Leu Asn Ser Glu Glu Ile 
 65                  70                  75                  80
Asn Tyr Val Ile Lys Gln Leu Ser Arg Glu Ser Leu Thr Gly Val Asp 
                 85                  90                  95
Val Leu Arg Glu Glu Ala Asn Glu Ile Leu Glu Glu Met Ser His Lys 
             100                105                110
Leu Arg Ile Gly Ala Ile Arg Phe Phe Ala Phe Val Leu Ser Lys Val 
         115                120                125
Phe Lys Gln Ile Phe Ser Lys Val Cys Val Asn Glu Glu Gly Ile Gln 
     130                135                140
Lys Leu Gln Arg Ala Ile Gln Glu His Pro Val Ile Leu Leu Pro Ser 
 145                150                155                160
His Arg Ser Tyr Ile Asp Phe Leu Met Leu Ser Phe Val Leu Tyr Asn 
                 165                170                175
Tyr Asp Leu Pro Val Pro Val Ile Ala Ala Gly Met Asp Phe Leu Gly 
             180                185                190
Met Arg Val Val Ser Glu Leu Leu Arg Met Ser Gly Ala Phe Phe Met 
         195                200                205
Arg Arg Thr Phe Gly Gly Asn Lys Leu Tyr Trp Ala Val Phe Ser Glu 
     210                215                220
Tyr Val Lys Thr Met Leu Arg Ser Gly Tyr Ala Pro Val Glu Phe Phe 
 225                230                235                240
Leu Glu Gly Thr Arg Ser Arg Ala Ala Lys Thr Leu Thr Pro Lys Phe 
                 245                250                255
Gly Leu Leu Asn Ile Val Met Glu Pro Phe Phe Lys Arg Glu Val Phe 
             260                265                270
Asp Thr Tyr Phe Val Pro Ile Ser Ile Ser Tyr Asp Lys Ile Leu Glu 
         275                280                285
Glu Ser Leu Tyr Ala Tyr Glu Leu Leu Gly Ile Pro Lys Pro Lys Glu 
     290                295                300
Ser Thr Thr Gly Leu Leu Lys Ala Arg Arg Ile Leu Ser Glu Asn Phe 
 305                310                315                320
Gly Ser Ile His Val Tyr Phe Gly Asp Pro Val Ser Leu Arg Ser Leu 
                 325                330                335
Ala Ala Gly Arg Leu Ser Arg Asn Thr Tyr Asn Leu Val Pro Arg Cys 
             340                345                350
Ile Pro Gln Lys Gln Pro Glu Asp Val Gln Ala Phe Val Thr Glu Val 
         355                360                365
Ala Tyr Lys Met Gln Leu Leu Gln Ile Glu Asn Leu Ala Leu Ser Pro 
     370                375                380
Trp Leu Leu Val Val Ala Ile Leu Leu Gln Asn Gln Leu Cys Met Asp 
 385                390                395                400
Phe Asp Ala Leu Val Glu Lys Thr Leu Trp Leu Lys Gly Leu Thr Gln 
                 405                410                415
Val Phe Gly Gly Phe Leu Leu Trp Pro Asp Asn Lys Leu Pro Glu Glu 
             420                425                430
Val Val Gln Ser Ser Ile Leu Leu His Ser Asn Leu Ala Thr Leu Val 
         435                440                445
Lys Asp Gln Val Val Leu Lys Val Asp Ser Glu Ser Ser Gln Met Val 
     450                455                460
Asn Gly Leu Val Pro Gln His Ile Ala Phe Leu Met Cys Ser Ala Tyr 
 465                470                475                480
Arg Asn Gln Leu Leu Asn Val Phe Ala Arg Pro Ser Leu Val Ala Val 
                 485                490                495
Ala Leu His Met Thr Pro Gly Leu Arg Lys Glu Asp Val Phe Ser Cys 
             500                505                510
Phe Ser Phe Leu Arg Asn Val Phe Ser Asp Glu Phe Ile Phe Leu Pro 
         515                520                525
Gly Asn Thr Leu Arg Asp Phe Glu Glu Gly Cys Tyr Leu Leu Cys Lys 
     530                535                540
Thr Glu Val Met Gln Met Thr Gly Lys Asp Ile Ile Leu Thr Asp Lys 
 545                550                555                560
Gly Asn Ala Val Leu Gln Phe Leu Thr Gly Leu Phe Lys Pro Phe Val 
                 565                570                575
Glu Ser Tyr Gln Ile Leu Ser Lys Cys Leu Leu His Glu Glu Asp Tyr 
             580                585                590
Phe Ser Glu Lys Glu Tyr Leu Val Thr Ala Arg Lys Phe Thr Arg Gln 
         595                600                605
Leu Leu Asp Gln Asp Ala Ser Gln Cys Tyr Asp Ala Leu Ser Ser Glu 
     610                615                620
Leu Gln Lys Asn Ala Leu Ala Ala Phe Val Arg Leu Gly Val Val Glu 
 625                630                635                640
Lys Asn Lys Val Asp Ser Lys Tyr Val Tyr Tyr Val Asn Gly Pro Ala 
                 645                650                655
Thr Ser Lys Leu Glu Glu Met Leu Gly Cys Lys Lys Pro Ile Gly Lys 
             660                665                670
Pro Ala Thr Ala Lys Leu 
         675



<210> 4506
<211> 2470
<212> DNA
<213> Homo sapiens
<308> NM_014236
<400> 4506

gaattcggc  cgagccggg  tcctgtgta  cggctgcag  gggtgccgc  gccctaggc  60
aagtagggc  gtcctgagc  aaagaaccg  ccccagcag  agcaccacc  cggcttagc  120
aagaatccc  gaccccgcc  gggaaggca  ccgcaccat  gagtcttcc  gttcatcta  180
ctcttattt  tccgttggc  caaccagtc  cagcgctgt  gtgctcctc  actcgaagg  240
gctcaaaaa  tgggatgag  ttgaagata  tttagaaga  aggaggcat  tcagtgact  300
gaaatttgc  atgaaatgc  acacacctc  tgtctataa  ggaattact  catgtaaac  360
aattgatat  aaatgtagt  ttctcaatt  tgaggagat  cattatgtc  ttaaacagc  420
ttccaagga  tcccttcaa  ctgtggatg  cctccgaga  gaagtgagt  agatcttag  480
tgaaatgag  cacaaactg  gtcttggag  cattcggtt  tgtgccttc  ccctgagca  540
agtatttaa  caaattttc  cgaaggtgt  tgtaaatga  gaaggtatt  agaaactac  600
aagagccat  caggagcat  ctgttgttc  gctgcctag  catcgaagt  acattgact  660
cctcatgtt  tcttttctt  tatacaatt  tgatttgcc  gtgccagtt  tagcagcag  720
aatggactt  ctgggaatg  aaatggttg  tgagctgct  cgaatgtcg  gtgcctttt  780
catgcggcg  acctttggt  gcaataaac  ctactgggc  gtattctct  aatatgtaa  840
aactatgtt  cggaatggt  atgctcctg  tgaattttt  ctcgaaggg  caagaagcc  900
ctctgccaa  acattgact  ctaaatttg  tcttctgaa  attgtgatg  agccatttt  960
taaaagaga  gtttttgat  cctaccttg  cccaattag  atcagttat  ataagatct  1020
ggaagaaac  ctttatgtg  atgagcttc  aggggttcc  aaaccaaaa  agtctacaa  1080
tgggttgct  aaagccaga  agattctct  tgaaaattt  ggaagcatc  atgtgtact  1140
tggagatcc  gtgtcactt  gatctttgg  agctgggag  atgagtcgg  gctcatata  1200
cttggttcc  agatacatt  ctcagaaac  gtctgagga  atgcatgcc  ttgtcactg  1260
agttgccta  aaaatggag  ttctgcaaa  tgaaaacat  gttttgagc  cctggaccc  1320
aatagttgc  gttctgctt  agaaccggc  atccatgga  tttgatgct  tggtggaaa  1380
gactttatg  ctaaaaggc  taacccagg  atttggagg  tttctcatt  ggcctgata  1440
taaacctgc  gaagaagtt  tcccggcca  cattcttct  cattccaac  ttgccagcc  1500
tgtcaaaga  caggtgatt  tgaaagtgg  ctccggaga  tcggaagtg  tcgatgggc  1560
tatgctcca  cacatcact  tcctcatgt  ctcagctta  aggaaccag  tgctcaaca  1620
ttttgtgcg  ccatcctta  tagcagtag  attgcagat  acaccaggg  tcaggaaag  1680
ggatgtcta  agttgcttt  gcttcctac  tgatgtttt  gcagatgag  tcatcttcc  1740
tccaggaaa  acactaaag  actttgaag  aggctgtta  ctgctttgt  aaagtgaag  1800
catacaagt  actacgaaa  acatcctag  tacagagaa  ggaaatact  tgttagaat  1860
tttagtagg  ctctttaaa  cttttgtgg  aagctatca  ataatttgc  agtaccttt  1920
gagtgaaga  gaggaccac  tcagtgagg  acagtactt  gctgcagtc  gaaaattca  1980
aagtcagct  ctcgatcaa  gtacctctc  atgttatga  gtattatct  ctgatgtgc  2040
gaaaaacgc  ttagcagcc  gtgtgaggc  cggagtagt  gagaagaag  agataaata  2100
taactgtat  tttaatgtg  atgaacctg  cacaaccaa  ttagaagaa  tgcttggtt  2160
taagacacc  ataggaaaa  cagccactg  aaaacttta  taatcaaca  atagttatg  2220
aaaattcgg  cacgtaatt  ctctcatcg  aggactcat  acaacaaac  gggaagtaa  2280
ggaagagac  catcctctc  tactccctg  gactctgag  acagtggac  cagagggaa  2340
agatgatca  tggaagcaa  cagtttact  ttccccacc  cagtggtta  aaggcgttt  2400
tatctgaca  tatgtgtgt  ttttaaaat  aacttttgg  aacatgaaa  aaaaaaaaa  2460
aaaactcgag  2470



<210> 4507
<211> 680
<212> PRT
<213> Homo sapiens
<308> O15228
<400> 4507

Met Glu Ser Ser Ser Ser Ser Asn Ser Tyr Phe Ser Val Gly Pro Thr 
  1               5                  10                  15
Ser Pro Ser Ala Val Val Leu Leu Tyr Ser Lys Glu Leu Lys Lys Trp 
             20                  25                  30
Asp Glu Phe Glu Asp Ile Leu Glu Glu Arg Arg His Val Ser Asp Leu 
         35                  40                  45
Lys Phe Ala Met Lys Cys Tyr Thr Pro Leu Val Tyr Lys Gly Ile Thr 
     50                  55                  60
Pro Cys Lys Pro Ile Asp Ile Lys Cys Ser Val Leu Asn Ser Glu Glu 
 65                  70                  75                  80
Ile His Tyr Val Ile Lys Gln Leu Ser Lys Glu Ser Leu Gln Ser Val 
                 85                  90                  95
Asp Val Leu Arg Glu Glu Val Ser Glu Ile Leu Asp Glu Met Ser His 
             100                105                110
Lys Leu Arg Leu Gly Ala Ile Arg Phe Cys Ala Phe Thr Leu Ser Lys 
         115                120                125
Val Phe Lys Gln Ile Phe Ser Lys Val Cys Val Asn Glu Glu Gly Ile 
     130                135                140
Gln Lys Leu Gln Arg Ala Ile Gln Glu His Pro Val Val Leu Leu Pro 
 145                150                155                160
Ser His Arg Ser Tyr Ile Asp Phe Leu Met Leu Ser Phe Leu Leu Tyr 
                 165                170                175
Asn Tyr Asp Leu Pro Val Pro Val Ile Ala Ala Gly Met Asp Phe Leu 
             180                185                190
Gly Met Lys Met Val Gly Glu Leu Leu Arg Met Ser Gly Ala Phe Phe 
         195                200                205
Met Arg Arg Thr Phe Gly Gly Asn Lys Leu Tyr Trp Ala Val Phe Ser 
     210                215                220
Glu Tyr Val Lys Thr Met Leu Arg Asn Gly Tyr Ala Pro Val Glu Phe 
 225                230                235                240
Phe Leu Glu Gly Thr Arg Ser Arg Ser Ala Lys Thr Leu Thr Pro Lys 
                 245                250                255
Phe Gly Leu Leu Asn Ile Val Met Glu Pro Phe Phe Lys Arg Glu Val 
             260                265                270
Phe Asp Thr Tyr Leu Val Pro Ile Ser Ile Ser Tyr Asp Lys Ile Leu 
         275                280                285
Glu Glu Thr Leu Tyr Val Tyr Glu Leu Leu Gly Val Pro Lys Pro Lys 
     290                295                300
Glu Ser Thr Thr Gly Leu Leu Lys Ala Arg Lys Ile Leu Ser Glu Asn 
 305                310                315                320
Phe Gly Ser Ile His Val Tyr Phe Gly Asp Pro Val Ser Leu Arg Ser 
                 325                330                335
Leu Ala Ala Gly Arg Met Ser Arg Ser Ser Tyr Asn Leu Val Pro Arg 
             340                345                350
Tyr Ile Pro Gln Lys Gln Ser Glu Asp Met His Ala Phe Val Thr Glu 
         355                360                365
Val Ala Tyr Lys Met Glu Leu Leu Gln Ile Glu Asn Met Val Leu Ser 
     370                375                380
Pro Trp Thr Leu Ile Val Ala Val Leu Leu Gln Asn Arg Pro Ser Met 
 385                390                395                400
Asp Phe Asp Ala Leu Val Glu Lys Thr Leu Trp Leu Lys Gly Leu Thr 
                 405                410                415
Gln Ala Phe Gly Gly Phe Leu Ile Trp Pro Asp Asn Lys Pro Ala Glu 
             420                425                430
Glu Val Val Pro Ala Ser Ile Leu Leu His Ser Asn Ile Ala Ser Leu 
         435                440                445
Val Lys Asp Gln Val Ile Leu Lys Val Asp Ser Gly Asp Ser Glu Val 
     450                455                460
Val Asp Gly Leu Met Leu Gln His Ile Thr Leu Leu Met Cys Ser Ala 
 465                470                475                480
Tyr Arg Asn Gln Leu Leu Asn Ile Phe Val Arg Pro Ser Leu Val Ala 
                 485                490                495
Val Ala Leu Gln Met Thr Pro Gly Phe Arg Lys Glu Asp Val Tyr Ser 
             500                505                510
Cys Phe Arg Phe Leu Arg Asp Val Phe Ala Asp Glu Phe Ile Phe Leu 
         515                520                525
Pro Gly Asn Thr Leu Lys Asp Phe Glu Glu Gly Cys Tyr Leu Leu Cys 
     530                535                540
Lys Ser Glu Ala Ile Gln Val Thr Thr Lys Asp Ile Leu Val Thr Glu 
 545                550                555                560
Lys Gly Asn Thr Val Leu Glu Phe Leu Val Gly Leu Phe Lys Pro Phe 
                 565                570                575
Val Glu Ser Tyr Gln Ile Ile Cys Lys Tyr Leu Leu Ser Glu Glu Glu 
             580                585                590
Asp His Phe Ser Glu Glu Gln Tyr Leu Ala Ala Val Arg Lys Phe Thr 
         595                600                605
Ser Gln Leu Leu Asp Gln Gly Thr Ser Gln Cys Tyr Asp Val Leu Ser 
     610                615                620
Ser Asp Val Gln Lys Asn Ala Leu Ala Ala Cys Val Arg Leu Gly Val 
 625                630                635                640
Val Glu Lys Lys Lys Ile Asn Asn Asn Cys Ile Phe Asn Val Asn Glu 
                 645                650                655
Pro Ala Thr Thr Lys Leu Glu Glu Met Leu Gly Cys Lys Thr Pro Ile 
             660                665                670
Gly Lys Pro Ala Thr Ala Lys Leu 
         675                680



<210> 4508
<211> 679
<212> DNA
<213> Rattus norvegicus
<308> AA799779
<400> 4508

caagactgc  ttattagac  acacagtga  atgaatgcc  ctggcagcc  tcatggtgg  60
acagtcaca  tgacattcc  atgctctcc  cctcctggc  gaagcacgg  tcacgggtc  120
caaggagac  gacgtcaca  cttcctctc  gcgcccatt  gtggcagag  aagtccttt  180
tgactgtca  tatggaact  tgttttctg  aactgctcc  tgattatca  agttttgca  240
tggctggtt  tcctattgg  ttcttacat  cgagcattt  ttctaactt  cttgtggca  300
gcccgttga  ataatacac  tatttactg  ctaccttat  cttttctac  accccgagt  360
tcacgaagg  tgctaaggc  ttcttctga  gttcagagg  cagcgcgtc  taacactga  420
aggcatctt  atccagaag  tggcgggtg  acttcctgg  tgtgaccaa  tactccttc  480
cactgaagt  gtcctcttc  tgcaagagg  atttggaaa  tatctgata  gattccaca  540
aaggtttaa  gagtcctgt  aggaactgt  atacagcat  ccctttgtc  gtgaggatg  600
tgtccttcc  agtcatctg  ataacctca  ttttacaca  caagtaaca  ccttcctca  660
agtccctga  tgtgtttcc  679



<210> 4509
<211> 678
<212> PRT
<213> Rattus norvegicus
<308> Q9ES71
<400> 4509

Met Asp Val Pro Ser Ser Ser Ser Ser Arg Phe Ser Val Gly Ser Ala 
  1               5                  10                  15
Ser Pro Ser Ser Val Leu Leu Tyr Ala Lys Asp Leu Lys Lys Trp Asp 
             20                  25                  30
Glu Phe Glu Asp Leu Leu Glu Glu Arg Arg Gln Val Ser Asp Phe Lys 
         35                  40                  45
Phe Ala Met Lys Cys Tyr Thr Pro Pro Leu Tyr Arg Gly Ile Thr Pro 
     50                  55                  60
Cys Lys Pro Ser Asp Ile Lys Ser Ile Val Leu Asn Ser Glu Glu Ile 
 65                  70                  75                  80
Asn Tyr Val Ile Lys Gln Leu Ser Arg Glu Ser Leu Thr Gly Val Asp 
                 85                  90                  95
Val Leu Arg Glu Glu Ala Asn Glu Ile Leu Glu Glu Met Ser His Lys 
             100                105                110
Leu Arg Ile Gly Ala Ile Arg Phe Phe Ala Phe Val Leu Ser Lys Val 
         115                120                125
Phe Lys Gln Ile Phe Ser Lys Val Cys Val Asn Glu Glu Gly Ile Gln 
     130                135                140
Lys Leu Gln Arg Ala Ile Gln Glu His Pro Val Ile Leu Leu Pro Ser 
 145                150                155                160
His Arg Ser Tyr Ile Asp Phe Leu Met Leu Ser Phe Val Leu Tyr Asn 
                 165                170                175
Tyr Asp Leu Pro Val Pro Val Ile Ala Ala Gly Met Asp Phe Leu Gly 
             180                185                190
Met Arg Val Val Ser Glu Leu Leu Arg Met Ser Gly Ala Phe Phe Met 
         195                200                205
Arg Arg Thr Phe Gly Gly Asn Lys Leu Tyr Trp Ala Val Phe Ser Glu 
     210                215                220
Tyr Val Lys Thr Met Leu Arg Ser Gly Tyr Ala Pro Val Glu Phe Phe 
 225                230                235                240
Leu Glu Gly Thr Arg Ser Arg Ala Ala Lys Thr Leu Thr Pro Lys Phe 
                 245                250                255
Gly Leu Leu Asn Ile Val Met Glu Pro Phe Phe Lys Arg Glu Val Phe 
             260                265                270
Asp Thr Tyr Phe Val Pro Ile Ser Ile Ser Tyr Asp Lys Ile Leu Glu 
         275                280                285
Glu Ser Leu Tyr Ala Tyr Glu Leu Leu Gly Ile Pro Lys Pro Lys Glu 
     290                295                300
Ser Thr Thr Gly Leu Leu Lys Ala Arg Arg Ile Leu Ser Glu Asn Phe 
 305                310                315                320
Gly Ser Ile His Val Tyr Phe Gly Asp Pro Val Ser Leu Arg Ser Leu 
                 325                330                335
Ala Ala Gly Arg Leu Ser Arg Asn Thr Tyr Asn Leu Val Pro Arg Cys 
             340                345                350
Ile Pro Gln Lys Gln Pro Glu Asp Val Gln Ala Phe Val Thr Glu Val 
         355                360                365
Ala Tyr Lys Met Gln Leu Leu Gln Ile Glu Asn Leu Ala Leu Ser Pro 
     370                375                380
Trp Leu Leu Val Val Ala Ile Leu Leu Gln Asn Gln Leu Cys Met Asp 
 385                390                395                400
Phe Asp Ala Leu Val Glu Lys Thr Leu Trp Leu Lys Gly Leu Thr Gln 
                 405                410                415
Val Phe Gly Gly Phe Leu Leu Trp Pro Asp Asn Lys Leu Pro Glu Glu 
             420                425                430
Val Val Gln Ser Ser Ile Leu Leu His Ser Asn Leu Ala Thr Leu Val 
         435                440                445
Lys Asp Gln Val Val Leu Lys Val Asp Ser Glu Ser Ser Gln Met Val 
     450                455                460
Asn Gly Leu Val Pro Gln His Ile Ala Phe Leu Met Cys Ser Ala Tyr 
 465                470                475                480
Arg Asn Gln Leu Leu Asn Val Phe Ala Arg Pro Ser Leu Val Ala Val 
                 485                490                495
Ala Leu His Met Thr Pro Gly Leu Arg Lys Glu Asp Val Phe Ser Cys 
             500                505                510
Phe Ser Phe Leu Arg Asn Val Phe Ser Asp Glu Phe Ile Phe Leu Pro 
         515                520                525
Gly Asn Thr Leu Arg Asp Phe Glu Glu Gly Cys Tyr Leu Leu Cys Lys 
     530                535                540
Thr Glu Val Met Gln Met Thr Gly Lys Asp Ile Ile Leu Thr Asp Lys 
 545                550                555                560
Gly Asn Ala Val Leu Gln Phe Leu Thr Gly Leu Phe Lys Pro Phe Val 
                 565                570                575
Glu Ser Tyr Gln Ile Leu Ser Lys Cys Leu Leu His Glu Glu Asp Tyr 
             580                585                590
Phe Ser Glu Lys Glu Tyr Leu Val Thr Ala Arg Lys Phe Thr Arg Gln 
         595                600                605
Leu Leu Asp Gln Asp Ala Ser Gln Cys Tyr Asp Ala Leu Ser Ser Glu 
     610                615                620
Leu Gln Lys Asn Ala Leu Ala Ala Phe Val Arg Leu Gly Val Val Glu 
 625                630                635                640
Lys Asn Lys Val Asp Ser Lys Tyr Val Tyr Tyr Val Asn Gly Pro Ala 
                 645                650                655
Thr Ser Lys Leu Glu Glu Met Leu Gly Cys Lys Lys Pro Ile Gly Lys 
             660                665                670
Pro Ala Thr Ala Lys Leu 
         675



<210> 4510
<211> 2470
<212> DNA
<213> Homo sapiens
<308> NM_014236
<400> 4510

gaattcggc  cgagccggg  tcctgtgta  cggctgcag  gggtgccgc  gccctaggc  60
aagtagggc  gtcctgagc  aaagaaccg  ccccagcag  agcaccacc  cggcttagc  120
aagaatccc  gaccccgcc  gggaaggca  ccgcaccat  gagtcttcc  gttcatcta  180
ctcttattt  tccgttggc  caaccagtc  cagcgctgt  gtgctcctc  actcgaagg  240
gctcaaaaa  tgggatgag  ttgaagata  tttagaaga  aggaggcat  tcagtgact  300
gaaatttgc  atgaaatgc  acacacctc  tgtctataa  ggaattact  catgtaaac  360
aattgatat  aaatgtagt  ttctcaatt  tgaggagat  cattatgtc  ttaaacagc  420
ttccaagga  tcccttcaa  ctgtggatg  cctccgaga  gaagtgagt  agatcttag  480
tgaaatgag  cacaaactg  gtcttggag  cattcggtt  tgtgccttc  ccctgagca  540
agtatttaa  caaattttc  cgaaggtgt  tgtaaatga  gaaggtatt  agaaactac  600
aagagccat  caggagcat  ctgttgttc  gctgcctag  catcgaagt  acattgact  660
cctcatgtt  tcttttctt  tatacaatt  tgatttgcc  gtgccagtt  tagcagcag  720
aatggactt  ctgggaatg  aaatggttg  tgagctgct  cgaatgtcg  gtgcctttt  780
catgcggcg  acctttggt  gcaataaac  ctactgggc  gtattctct  aatatgtaa  840
aactatgtt  cggaatggt  atgctcctg  tgaattttt  ctcgaaggg  caagaagcc  900
ctctgccaa  acattgact  ctaaatttg  tcttctgaa  attgtgatg  agccatttt  960
taaaagaga  gtttttgat  cctaccttg  cccaattag  atcagttat  ataagatct  1020
ggaagaaac  ctttatgtg  atgagcttc  aggggttcc  aaaccaaaa  agtctacaa  1080
tgggttgct  aaagccaga  agattctct  tgaaaattt  ggaagcatc  atgtgtact  1140
tggagatcc  gtgtcactt  gatctttgg  agctgggag  atgagtcgg  gctcatata  1200
cttggttcc  agatacatt  ctcagaaac  gtctgagga  atgcatgcc  ttgtcactg  1260
agttgccta  aaaatggag  ttctgcaaa  tgaaaacat  gttttgagc  cctggaccc  1320
aatagttgc  gttctgctt  agaaccggc  atccatgga  tttgatgct  tggtggaaa  1380
gactttatg  ctaaaaggc  taacccagg  atttggagg  tttctcatt  ggcctgata  1440
taaacctgc  gaagaagtt  tcccggcca  cattcttct  cattccaac  ttgccagcc  1500
tgtcaaaga  caggtgatt  tgaaagtgg  ctccggaga  tcggaagtg  tcgatgggc  1560
tatgctcca  cacatcact  tcctcatgt  ctcagctta  aggaaccag  tgctcaaca  1620
ttttgtgcg  ccatcctta  tagcagtag  attgcagat  acaccaggg  tcaggaaag  1680
ggatgtcta  agttgcttt  gcttcctac  tgatgtttt  gcagatgag  tcatcttcc  1740
tccaggaaa  acactaaag  actttgaag  aggctgtta  ctgctttgt  aaagtgaag  1800
catacaagt  actacgaaa  acatcctag  tacagagaa  ggaaatact  tgttagaat  1860
tttagtagg  ctctttaaa  cttttgtgg  aagctatca  ataatttgc  agtaccttt  1920
gagtgaaga  gaggaccac  tcagtgagg  acagtactt  gctgcagtc  gaaaattca  1980
aagtcagct  ctcgatcaa  gtacctctc  atgttatga  gtattatct  ctgatgtgc  2040
gaaaaacgc  ttagcagcc  gtgtgaggc  cggagtagt  gagaagaag  agataaata  2100
taactgtat  tttaatgtg  atgaacctg  cacaaccaa  ttagaagaa  tgcttggtt  2160
taagacacc  ataggaaaa  cagccactg  aaaacttta  taatcaaca  atagttatg  2220
aaaattcgg  cacgtaatt  ctctcatcg  aggactcat  acaacaaac  gggaagtaa  2280
ggaagagac  catcctctc  tactccctg  gactctgag  acagtggac  cagagggaa  2340
agatgatca  tggaagcaa  cagtttact  ttccccacc  cagtggtta  aaggcgttt  2400
tatctgaca  tatgtgtgt  ttttaaaat  aacttttgg  aacatgaaa  aaaaaaaaa  2460
aaaactcgag  2470



<210> 4511
<211> 680
<212> PRT
<213> Homo sapiens
<308> O15228
<400> 4511

Met Glu Ser Ser Ser Ser Ser Asn Ser Tyr Phe Ser Val Gly Pro Thr 
  1               5                  10                  15
Ser Pro Ser Ala Val Val Leu Leu Tyr Ser Lys Glu Leu Lys Lys Trp 
             20                  25                  30
Asp Glu Phe Glu Asp Ile Leu Glu Glu Arg Arg His Val Ser Asp Leu 
         35                  40                  45
Lys Phe Ala Met Lys Cys Tyr Thr Pro Leu Val Tyr Lys Gly Ile Thr 
     50                  55                  60
Pro Cys Lys Pro Ile Asp Ile Lys Cys Ser Val Leu Asn Ser Glu Glu 
 65                  70                  75                  80
Ile His Tyr Val Ile Lys Gln Leu Ser Lys Glu Ser Leu Gln Ser Val 
                 85                  90                  95
Asp Val Leu Arg Glu Glu Val Ser Glu Ile Leu Asp Glu Met Ser His 
             100                105                110
Lys Leu Arg Leu Gly Ala Ile Arg Phe Cys Ala Phe Thr Leu Ser Lys 
         115                120                125
Val Phe Lys Gln Ile Phe Ser Lys Val Cys Val Asn Glu Glu Gly Ile 
     130                135                140
Gln Lys Leu Gln Arg Ala Ile Gln Glu His Pro Val Val Leu Leu Pro 
 145                150                155                160
Ser His Arg Ser Tyr Ile Asp Phe Leu Met Leu Ser Phe Leu Leu Tyr 
                 165                170                175
Asn Tyr Asp Leu Pro Val Pro Val Ile Ala Ala Gly Met Asp Phe Leu 
             180                185                190
Gly Met Lys Met Val Gly Glu Leu Leu Arg Met Ser Gly Ala Phe Phe 
         195                200                205
Met Arg Arg Thr Phe Gly Gly Asn Lys Leu Tyr Trp Ala Val Phe Ser 
     210                215                220
Glu Tyr Val Lys Thr Met Leu Arg Asn Gly Tyr Ala Pro Val Glu Phe 
 225                230                235                240
Phe Leu Glu Gly Thr Arg Ser Arg Ser Ala Lys Thr Leu Thr Pro Lys 
                 245                250                255
Phe Gly Leu Leu Asn Ile Val Met Glu Pro Phe Phe Lys Arg Glu Val 
             260                265                270
Phe Asp Thr Tyr Leu Val Pro Ile Ser Ile Ser Tyr Asp Lys Ile Leu 
         275                280                285
Glu Glu Thr Leu Tyr Val Tyr Glu Leu Leu Gly Val Pro Lys Pro Lys 
     290                295                300
Glu Ser Thr Thr Gly Leu Leu Lys Ala Arg Lys Ile Leu Ser Glu Asn 
 305                310                315                320
Phe Gly Ser Ile His Val Tyr Phe Gly Asp Pro Val Ser Leu Arg Ser 
                 325                330                335
Leu Ala Ala Gly Arg Met Ser Arg Ser Ser Tyr Asn Leu Val Pro Arg 
             340                345                350
Tyr Ile Pro Gln Lys Gln Ser Glu Asp Met His Ala Phe Val Thr Glu 
         355                360                365
Val Ala Tyr Lys Met Glu Leu Leu Gln Ile Glu Asn Met Val Leu Ser 
     370                375                380
Pro Trp Thr Leu Ile Val Ala Val Leu Leu Gln Asn Arg Pro Ser Met 
 385                390                395                400
Asp Phe Asp Ala Leu Val Glu Lys Thr Leu Trp Leu Lys Gly Leu Thr 
                 405                410                415
Gln Ala Phe Gly Gly Phe Leu Ile Trp Pro Asp Asn Lys Pro Ala Glu 
             420                425                430
Glu Val Val Pro Ala Ser Ile Leu Leu His Ser Asn Ile Ala Ser Leu 
         435                440                445
Val Lys Asp Gln Val Ile Leu Lys Val Asp Ser Gly Asp Ser Glu Val 
     450                455                460
Val Asp Gly Leu Met Leu Gln His Ile Thr Leu Leu Met Cys Ser Ala 
 465                470                475                480
Tyr Arg Asn Gln Leu Leu Asn Ile Phe Val Arg Pro Ser Leu Val Ala 
                 485                490                495
Val Ala Leu Gln Met Thr Pro Gly Phe Arg Lys Glu Asp Val Tyr Ser 
             500                505                510
Cys Phe Arg Phe Leu Arg Asp Val Phe Ala Asp Glu Phe Ile Phe Leu 
         515                520                525
Pro Gly Asn Thr Leu Lys Asp Phe Glu Glu Gly Cys Tyr Leu Leu Cys 
     530                535                540
Lys Ser Glu Ala Ile Gln Val Thr Thr Lys Asp Ile Leu Val Thr Glu 
 545                550                555                560
Lys Gly Asn Thr Val Leu Glu Phe Leu Val Gly Leu Phe Lys Pro Phe 
                 565                570                575
Val Glu Ser Tyr Gln Ile Ile Cys Lys Tyr Leu Leu Ser Glu Glu Glu 
             580                585                590
Asp His Phe Ser Glu Glu Gln Tyr Leu Ala Ala Val Arg Lys Phe Thr 
         595                600                605
Ser Gln Leu Leu Asp Gln Gly Thr Ser Gln Cys Tyr Asp Val Leu Ser 
     610                615                620
Ser Asp Val Gln Lys Asn Ala Leu Ala Ala Cys Val Arg Leu Gly Val 
 625                630                635                640
Val Glu Lys Lys Lys Ile Asn Asn Asn Cys Ile Phe Asn Val Asn Glu 
                 645                650                655
Pro Ala Thr Thr Lys Leu Glu Glu Met Leu Gly Cys Lys Thr Pro Ile 
             660                665                670
Gly Lys Pro Ala Thr Ala Lys Leu 
         675                680



<210> 4512
<211> 679
<212> DNA
<213> Rattus norvegicus
<308> AA799779
<400> 4512

caagactgc  ttattagac  acacagtga  atgaatgcc  ctggcagcc  tcatggtgg  60
acagtcaca  tgacattcc  atgctctcc  cctcctggc  gaagcacgg  tcacgggtc  120
caaggagac  gacgtcaca  cttcctctc  gcgcccatt  gtggcagag  aagtccttt  180
tgactgtca  tatggaact  tgttttctg  aactgctcc  tgattatca  agttttgca  240
tggctggtt  tcctattgg  ttcttacat  cgagcattt  ttctaactt  cttgtggca  300
gcccgttga  ataatacac  tatttactg  ctaccttat  cttttctac  accccgagt  360
tcacgaagg  tgctaaggc  ttcttctga  gttcagagg  cagcgcgtc  taacactga  420
aggcatctt  atccagaag  tggcgggtg  acttcctgg  tgtgaccaa  tactccttc  480
cactgaagt  gtcctcttc  tgcaagagg  atttggaaa  tatctgata  gattccaca  540
aaggtttaa  gagtcctgt  aggaactgt  atacagcat  ccctttgtc  gtgaggatg  600
tgtccttcc  agtcatctg  ataacctca  ttttacaca  caagtaaca  ccttcctca  660
agtccctga  tgtgtttcc  679



<210> 4513
<211> 678
<212> PRT
<213> Rattus norvegicus
<308> Q9ES71
<400> 4513

Met Asp Val Pro Ser Ser Ser Ser Ser Arg Phe Ser Val Gly Ser Ala 
  1               5                  10                  15
Ser Pro Ser Ser Val Leu Leu Tyr Ala Lys Asp Leu Lys Lys Trp Asp 
             20                  25                  30
Glu Phe Glu Asp Leu Leu Glu Glu Arg Arg Gln Val Ser Asp Phe Lys 
         35                  40                  45
Phe Ala Met Lys Cys Tyr Thr Pro Pro Leu Tyr Arg Gly Ile Thr Pro 
     50                  55                  60
Cys Lys Pro Ser Asp Ile Lys Ser Ile Val Leu Asn Ser Glu Glu Ile 
 65                  70                  75                  80
Asn Tyr Val Ile Lys Gln Leu Ser Arg Glu Ser Leu Thr Gly Val Asp 
                 85                  90                  95
Val Leu Arg Glu Glu Ala Asn Glu Ile Leu Glu Glu Met Ser His Lys 
             100                105                110
Leu Arg Ile Gly Ala Ile Arg Phe Phe Ala Phe Val Leu Ser Lys Val 
         115                120                125
Phe Lys Gln Ile Phe Ser Lys Val Cys Val Asn Glu Glu Gly Ile Gln 
     130                135                140
Lys Leu Gln Arg Ala Ile Gln Glu His Pro Val Ile Leu Leu Pro Ser 
 145                150                155                160
His Arg Ser Tyr Ile Asp Phe Leu Met Leu Ser Phe Val Leu Tyr Asn 
                 165                170                175
Tyr Asp Leu Pro Val Pro Val Ile Ala Ala Gly Met Asp Phe Leu Gly 
             180                185                190
Met Arg Val Val Ser Glu Leu Leu Arg Met Ser Gly Ala Phe Phe Met 
         195                200                205
Arg Arg Thr Phe Gly Gly Asn Lys Leu Tyr Trp Ala Val Phe Ser Glu 
     210                215                220
Tyr Val Lys Thr Met Leu Arg Ser Gly Tyr Ala Pro Val Glu Phe Phe 
 225                230                235                240
Leu Glu Gly Thr Arg Ser Arg Ala Ala Lys Thr Leu Thr Pro Lys Phe 
                 245                250                255
Gly Leu Leu Asn Ile Val Met Glu Pro Phe Phe Lys Arg Glu Val Phe 
             260                265                270
Asp Thr Tyr Phe Val Pro Ile Ser Ile Ser Tyr Asp Lys Ile Leu Glu 
         275                280                285
Glu Ser Leu Tyr Ala Tyr Glu Leu Leu Gly Ile Pro Lys Pro Lys Glu 
     290                295                300
Ser Thr Thr Gly Leu Leu Lys Ala Arg Arg Ile Leu Ser Glu Asn Phe 
 305                310                315                320
Gly Ser Ile His Val Tyr Phe Gly Asp Pro Val Ser Leu Arg Ser Leu 
                 325                330                335
Ala Ala Gly Arg Leu Ser Arg Asn Thr Tyr Asn Leu Val Pro Arg Cys 
             340                345                350
Ile Pro Gln Lys Gln Pro Glu Asp Val Gln Ala Phe Val Thr Glu Val 
         355                360                365
Ala Tyr Lys Met Gln Leu Leu Gln Ile Glu Asn Leu Ala Leu Ser Pro 
     370                375                380
Trp Leu Leu Val Val Ala Ile Leu Leu Gln Asn Gln Leu Cys Met Asp 
 385                390                395                400
Phe Asp Ala Leu Val Glu Lys Thr Leu Trp Leu Lys Gly Leu Thr Gln 
                 405                410                415
Val Phe Gly Gly Phe Leu Leu Trp Pro Asp Asn Lys Leu Pro Glu Glu 
             420                425                430
Val Val Gln Ser Ser Ile Leu Leu His Ser Asn Leu Ala Thr Leu Val 
         435                440                445
Lys Asp Gln Val Val Leu Lys Val Asp Ser Glu Ser Ser Gln Met Val 
     450                455                460
Asn Gly Leu Val Pro Gln His Ile Ala Phe Leu Met Cys Ser Ala Tyr 
 465                470                475                480
Arg Asn Gln Leu Leu Asn Val Phe Ala Arg Pro Ser Leu Val Ala Val 
                 485                490                495
Ala Leu His Met Thr Pro Gly Leu Arg Lys Glu Asp Val Phe Ser Cys 
             500                505                510
Phe Ser Phe Leu Arg Asn Val Phe Ser Asp Glu Phe Ile Phe Leu Pro 
         515                520                525
Gly Asn Thr Leu Arg Asp Phe Glu Glu Gly Cys Tyr Leu Leu Cys Lys 
     530                535                540
Thr Glu Val Met Gln Met Thr Gly Lys Asp Ile Ile Leu Thr Asp Lys 
 545                550                555                560
Gly Asn Ala Val Leu Gln Phe Leu Thr Gly Leu Phe Lys Pro Phe Val 
                 565                570                575
Glu Ser Tyr Gln Ile Leu Ser Lys Cys Leu Leu His Glu Glu Asp Tyr 
             580                585                590
Phe Ser Glu Lys Glu Tyr Leu Val Thr Ala Arg Lys Phe Thr Arg Gln 
         595                600                605
Leu Leu Asp Gln Asp Ala Ser Gln Cys Tyr Asp Ala Leu Ser Ser Glu 
     610                615                620
Leu Gln Lys Asn Ala Leu Ala Ala Phe Val Arg Leu Gly Val Val Glu 
 625                630                635                640
Lys Asn Lys Val Asp Ser Lys Tyr Val Tyr Tyr Val Asn Gly Pro Ala 
                 645                650                655
Thr Ser Lys Leu Glu Glu Met Leu Gly Cys Lys Lys Pro Ile Gly Lys 
             660                665                670
Pro Ala Thr Ala Lys Leu 
         675



<210> 4514
<211> 2470
<212> DNA
<213> Homo sapiens
<308> NM_014236
<400> 4514

gaattcggc  cgagccggg  tcctgtgta  cggctgcag  gggtgccgc  gccctaggc  60
aagtagggc  gtcctgagc  aaagaaccg  ccccagcag  agcaccacc  cggcttagc  120
aagaatccc  gaccccgcc  gggaaggca  ccgcaccat  gagtcttcc  gttcatcta  180
ctcttattt  tccgttggc  caaccagtc  cagcgctgt  gtgctcctc  actcgaagg  240
gctcaaaaa  tgggatgag  ttgaagata  tttagaaga  aggaggcat  tcagtgact  300
gaaatttgc  atgaaatgc  acacacctc  tgtctataa  ggaattact  catgtaaac  360
aattgatat  aaatgtagt  ttctcaatt  tgaggagat  cattatgtc  ttaaacagc  420
ttccaagga  tcccttcaa  ctgtggatg  cctccgaga  gaagtgagt  agatcttag  480
tgaaatgag  cacaaactg  gtcttggag  cattcggtt  tgtgccttc  ccctgagca  540
agtatttaa  caaattttc  cgaaggtgt  tgtaaatga  gaaggtatt  agaaactac  600
aagagccat  caggagcat  ctgttgttc  gctgcctag  catcgaagt  acattgact  660
cctcatgtt  tcttttctt  tatacaatt  tgatttgcc  gtgccagtt  tagcagcag  720
aatggactt  ctgggaatg  aaatggttg  tgagctgct  cgaatgtcg  gtgcctttt  780
catgcggcg  acctttggt  gcaataaac  ctactgggc  gtattctct  aatatgtaa  840
aactatgtt  cggaatggt  atgctcctg  tgaattttt  ctcgaaggg  caagaagcc  900
ctctgccaa  acattgact  ctaaatttg  tcttctgaa  attgtgatg  agccatttt  960
taaaagaga  gtttttgat  cctaccttg  cccaattag  atcagttat  ataagatct  1020
ggaagaaac  ctttatgtg  atgagcttc  aggggttcc  aaaccaaaa  agtctacaa  1080
tgggttgct  aaagccaga  agattctct  tgaaaattt  ggaagcatc  atgtgtact  1140
tggagatcc  gtgtcactt  gatctttgg  agctgggag  atgagtcgg  gctcatata  1200
cttggttcc  agatacatt  ctcagaaac  gtctgagga  atgcatgcc  ttgtcactg  1260
agttgccta  aaaatggag  ttctgcaaa  tgaaaacat  gttttgagc  cctggaccc  1320
aatagttgc  gttctgctt  agaaccggc  atccatgga  tttgatgct  tggtggaaa  1380
gactttatg  ctaaaaggc  taacccagg  atttggagg  tttctcatt  ggcctgata  1440
taaacctgc  gaagaagtt  tcccggcca  cattcttct  cattccaac  ttgccagcc  1500
tgtcaaaga  caggtgatt  tgaaagtgg  ctccggaga  tcggaagtg  tcgatgggc  1560
tatgctcca  cacatcact  tcctcatgt  ctcagctta  aggaaccag  tgctcaaca  1620
ttttgtgcg  ccatcctta  tagcagtag  attgcagat  acaccaggg  tcaggaaag  1680
ggatgtcta  agttgcttt  gcttcctac  tgatgtttt  gcagatgag  tcatcttcc  1740
tccaggaaa  acactaaag  actttgaag  aggctgtta  ctgctttgt  aaagtgaag  1800
catacaagt  actacgaaa  acatcctag  tacagagaa  ggaaatact  tgttagaat  1860
tttagtagg  ctctttaaa  cttttgtgg  aagctatca  ataatttgc  agtaccttt  1920
gagtgaaga  gaggaccac  tcagtgagg  acagtactt  gctgcagtc  gaaaattca  1980
aagtcagct  ctcgatcaa  gtacctctc  atgttatga  gtattatct  ctgatgtgc  2040
gaaaaacgc  ttagcagcc  gtgtgaggc  cggagtagt  gagaagaag  agataaata  2100
taactgtat  tttaatgtg  atgaacctg  cacaaccaa  ttagaagaa  tgcttggtt  2160
taagacacc  ataggaaaa  cagccactg  aaaacttta  taatcaaca  atagttatg  2220
aaaattcgg  cacgtaatt  ctctcatcg  aggactcat  acaacaaac  gggaagtaa  2280
ggaagagac  catcctctc  tactccctg  gactctgag  acagtggac  cagagggaa  2340
agatgatca  tggaagcaa  cagtttact  ttccccacc  cagtggtta  aaggcgttt  2400
tatctgaca  tatgtgtgt  ttttaaaat  aacttttgg  aacatgaaa  aaaaaaaaa  2460
aaaactcgag  2470



<210> 4515
<211> 680
<212> PRT
<213> Homo sapiens
<308> O15228
<400> 4515

Met Glu Ser Ser Ser Ser Ser Asn Ser Tyr Phe Ser Val Gly Pro Thr 
  1               5                  10                  15
Ser Pro Ser Ala Val Val Leu Leu Tyr Ser Lys Glu Leu Lys Lys Trp 
             20                  25                  30
Asp Glu Phe Glu Asp Ile Leu Glu Glu Arg Arg His Val Ser Asp Leu 
         35                  40                  45
Lys Phe Ala Met Lys Cys Tyr Thr Pro Leu Val Tyr Lys Gly Ile Thr 
     50                  55                  60
Pro Cys Lys Pro Ile Asp Ile Lys Cys Ser Val Leu Asn Ser Glu Glu 
 65                  70                  75                  80
Ile His Tyr Val Ile Lys Gln Leu Ser Lys Glu Ser Leu Gln Ser Val 
                 85                  90                  95
Asp Val Leu Arg Glu Glu Val Ser Glu Ile Leu Asp Glu Met Ser His 
             100                105                110
Lys Leu Arg Leu Gly Ala Ile Arg Phe Cys Ala Phe Thr Leu Ser Lys 
         115                120                125
Val Phe Lys Gln Ile Phe Ser Lys Val Cys Val Asn Glu Glu Gly Ile 
     130                135                140
Gln Lys Leu Gln Arg Ala Ile Gln Glu His Pro Val Val Leu Leu Pro 
 145                150                155                160
Ser His Arg Ser Tyr Ile Asp Phe Leu Met Leu Ser Phe Leu Leu Tyr 
                 165                170                175
Asn Tyr Asp Leu Pro Val Pro Val Ile Ala Ala Gly Met Asp Phe Leu 
             180                185                190
Gly Met Lys Met Val Gly Glu Leu Leu Arg Met Ser Gly Ala Phe Phe 
         195                200                205
Met Arg Arg Thr Phe Gly Gly Asn Lys Leu Tyr Trp Ala Val Phe Ser 
     210                215                220
Glu Tyr Val Lys Thr Met Leu Arg Asn Gly Tyr Ala Pro Val Glu Phe 
 225                230                235                240
Phe Leu Glu Gly Thr Arg Ser Arg Ser Ala Lys Thr Leu Thr Pro Lys 
                 245                250                255
Phe Gly Leu Leu Asn Ile Val Met Glu Pro Phe Phe Lys Arg Glu Val 
             260                265                270
Phe Asp Thr Tyr Leu Val Pro Ile Ser Ile Ser Tyr Asp Lys Ile Leu 
         275                280                285
Glu Glu Thr Leu Tyr Val Tyr Glu Leu Leu Gly Val Pro Lys Pro Lys 
     290                295                300
Glu Ser Thr Thr Gly Leu Leu Lys Ala Arg Lys Ile Leu Ser Glu Asn 
 305                310                315                320
Phe Gly Ser Ile His Val Tyr Phe Gly Asp Pro Val Ser Leu Arg Ser 
                 325                330                335
Leu Ala Ala Gly Arg Met Ser Arg Ser Ser Tyr Asn Leu Val Pro Arg 
             340                345                350
Tyr Ile Pro Gln Lys Gln Ser Glu Asp Met His Ala Phe Val Thr Glu 
         355                360                365
Val Ala Tyr Lys Met Glu Leu Leu Gln Ile Glu Asn Met Val Leu Ser 
     370                375                380
Pro Trp Thr Leu Ile Val Ala Val Leu Leu Gln Asn Arg Pro Ser Met 
 385                390                395                400
Asp Phe Asp Ala Leu Val Glu Lys Thr Leu Trp Leu Lys Gly Leu Thr 
                 405                410                415
Gln Ala Phe Gly Gly Phe Leu Ile Trp Pro Asp Asn Lys Pro Ala Glu 
             420                425                430
Glu Val Val Pro Ala Ser Ile Leu Leu His Ser Asn Ile Ala Ser Leu 
         435                440                445
Val Lys Asp Gln Val Ile Leu Lys Val Asp Ser Gly Asp Ser Glu Val 
     450                455                460
Val Asp Gly Leu Met Leu Gln His Ile Thr Leu Leu Met Cys Ser Ala 
 465                470                475                480
Tyr Arg Asn Gln Leu Leu Asn Ile Phe Val Arg Pro Ser Leu Val Ala 
                 485                490                495
Val Ala Leu Gln Met Thr Pro Gly Phe Arg Lys Glu Asp Val Tyr Ser 
             500                505                510
Cys Phe Arg Phe Leu Arg Asp Val Phe Ala Asp Glu Phe Ile Phe Leu 
         515                520                525
Pro Gly Asn Thr Leu Lys Asp Phe Glu Glu Gly Cys Tyr Leu Leu Cys 
     530                535                540
Lys Ser Glu Ala Ile Gln Val Thr Thr Lys Asp Ile Leu Val Thr Glu 
 545                550                555                560
Lys Gly Asn Thr Val Leu Glu Phe Leu Val Gly Leu Phe Lys Pro Phe 
                 565                570                575
Val Glu Ser Tyr Gln Ile Ile Cys Lys Tyr Leu Leu Ser Glu Glu Glu 
             580                585                590
Asp His Phe Ser Glu Glu Gln Tyr Leu Ala Ala Val Arg Lys Phe Thr 
         595                600                605
Ser Gln Leu Leu Asp Gln Gly Thr Ser Gln Cys Tyr Asp Val Leu Ser 
     610                615                620
Ser Asp Val Gln Lys Asn Ala Leu Ala Ala Cys Val Arg Leu Gly Val 
 625                630                635                640
Val Glu Lys Lys Lys Ile Asn Asn Asn Cys Ile Phe Asn Val Asn Glu 
                 645                650                655
Pro Ala Thr Thr Lys Leu Glu Glu Met Leu Gly Cys Lys Thr Pro Ile 
             660                665                670
Gly Lys Pro Ala Thr Ala Lys Leu 
         675                680



<210> 4516
<211> 609
<212> DNA
<213> Rattus norvegicus
<308> AA799783
<400> 4516

catccctcc  caaaaagac  tgggtcggt  cagcaatca  aaaaaggag  tacaaacac  60
agagtcaaa  gtctcccgc  ctgacactt  caaaaaacc  ggaattata  acagggttt  120
caaacagga  ctgcagcag  tactaatgt  cctttacaa  agtcacaca  gcctattag  180
acagtattt  cagacaccc  actctggaa  taatctaca  ggacatccc  acacccacc  240
ctctatgcc  agaaaaata  caaaacaca  ccaaagtgc  tttgtttgt  tatatcaaa  300
catctctcc  tctccccgg  ccaccccag  cccaccccc  ttgaagatt  gcctgcaag  360
ctattttaa  catttagtt  ttttttata  tttatgaaa  taaattata  agcaactat  420
ttaataaat  aagcacaga  ggagaataa  gaggaaact  aatgggaag  caaaagcca  480
gccacactt  ggctaggag  gcaggggtg  cttagcagg  cagagtggt  gtgggggta  540
ggctccccg  tggtgaaga  cccccaacc  ctgagtcca  actgacacc  ctcagcacg  600
agtttctga  609



<210> 4517
<211> 249
<212> DNA
<213> Homo sapiens
<308> AI682207
<400> 4517

ttttttttt  ttttaattt  taaacattt  tatttcaaa  cttttttca  ccctcccca  60
aaagacatg  gtaggtaca  caatcataa  aaggagata  aaacacaag  gtcaaatgt  120
tctcgcact  acacttaca  aaaactggg  attgtacat  gggttaggg  tgtccctgt  180
gattagttc  agaatgggg  gtctgtata  actgtatta  taggcatgt  tgactctcg  240
aaagggacg  249



<210> 4518
<211> 673
<212> DNA
<213> Rattus norvegicus
<308> AA799784
<400> 4518

ggcagcaaa  ttgtgttaa  aaaaaaaat  tagaccatg  acatgtttt  ctgcttcag  60
ttaagaatc  caagccaaa  aaaaagagc  gcacagaaa  cagcaagct  gttacttcc  120
gacaaataa  aaggatcaa  tgcaacagc  ggaagacaa  cactccccc  tttccagaa  180
tcacaattc  ttcaaataa  gaatgtgaa  catgtgcca  attgaattg  tatttattt  240
aggacatgc  atgtcaaaa  aaaacaaaa  agtcaatcc  tgcttttaa  aataatatg  300
attataaaa  cactttaca  ctctatccc  tgtttgagt  taagttaca  ggtatgtgg  360
ctaatgatt  tctgaaagt  tttctctat  cagatccat  atccaagtg  tctccaagt  420
ttacaaggt  acagtacgt  gaagtggag  aggacaggg  ggggagtcg  gctttccag  480
taggaattt  gttgcaatg  ggaggtgag  aagtatgaa  ttatttttg  taccttttc  540
tctttatac  gtgttaagt  atgcttaca  cataaaccc  gcaggcttc  tctgagtta  600
aactcagaa  tttttccct  caaataatg  atttacaaa  gtgtttatt  acttacaca  660
caatctcaa  ctc  673



<210> 4519
<211> 140
<212> PRT
<213> Rattus norvegicus
<308> AAD38018
<400> 4519

Thr Ala Gly Gln Glu Arg Phe Arg Ser Leu Ile Pro Ser Tyr Ile Arg 
  1               5                  10                  15
Asp Ser Thr Val Ala Val Val Val Tyr Asp Ile Thr Asn Val Asn Ser 
             20                  25                  30
Phe Gln Gln Thr Thr Lys Trp Ile Asp Asp Val Arg Thr Glu Arg Gly 
         35                  40                  45
Ser Asp Val Ile Ile Met Leu Val Gly Asn Lys Thr Asp Leu Ala Asp 
     50                  55                  60
Lys Arg Gln Val Ser Ile Glu Glu Gly Glu Arg Lys Ala Lys Glu Leu 
 65                  70                  75                  80
Asn Val Met Phe Ile Glu Thr Ser Ala Lys Ala Gly Tyr Asn Val Lys 
                 85                  90                  95
Gln Leu Phe Arg Arg Val Ala Ala Ala Leu Pro Gly Met Glu Ser Thr 
             100                105                110
Gln Asp Arg Ser Arg Glu Asp Met Ile Asp Ile Lys Leu Glu Lys Pro 
         115                120                125
Gln Glu Gln Pro Val Asn Glu Gly Gly Cys Ser Cys 
     130                135                140



<210> 4520
<211> 3084
<212> DNA
<213> Homo sapiens
<308> AL136727
<400> 4520

ggggcactc  gcaggttgg  ctgcggcgg  ggcggctgg  gaagccgaa  cgccgcgcg  60
gagagatcc  ggatacatc  gcggtttgg  ctccgccac  ctccgtctc  ctcccgcag  120
tctctgagc  gggtgcgga  ggagggaac  gccctagcc  tgggaagcc  aagcacacc  180
ctggctccc  ccgacaccg  cctccttcc  ttcccagcc  cgggcctcg  tccgtgctc  240
gctactctg  cgggaggcg  cggcggctg  cagtctgtg  cgagccctg  tgccctcca  300
ccgggcttc  ccagccggg  tcctccacc  gcccttgca  gggcacaga  agctcggcg  360
ccgcccttc  gctcgcctt  ttcgtcagc  ggctggagg  gcatcggtc  gggaggtct  420
tgggctgag  cggcgacag  tcctctagt  ccaccatgt  cgcgggcgg  gacttcggg  480
atccgctga  gaaattcaa  ctggtgttc  tgggggagc  aagcgttgc  aagacatct  540
tgatcacca  attcaggta  gacagtttt  acaacacct  tcaggcaat  attggcatt  600
actttttat  aaaaactat  tacttggag  atggaacaa  cgggcttcg  ctgtgggat  660
cggcgggtc  ggaacgtct  cgtagcctc  ttcccaggt  catccgtga  tctgctgca  720
ctgtagtag  ttacgatat  acaaatgtt  actcattcc  gcaaactac  aagtggatt  780
atgatgtca  aacagaaag  ggaagtgat  ttatcatca  gctagtagg  aatagaaca  840
atcttgctg  caagaggca  gtgtcagtt  aggagggag  gaggaaagc  aaagggctg  900
atgttacgt  tattgaaac  agggcaaaa  ctggataca  tgtaaagca  ctctttcga  960
gtgtagcag  agctttgcc  ggaatggaa  gcacacagg  cggaagcag  gaagacatg  1020
gtgacataa  actggaaaa  cctcaggag  aaacagtca  cgaaggggg  tgttcctgc  1080
actctccca  gtcatcttc  acccttcct  agaagcccc  ttactcttt  attgactgc  1140
gtgtgaata  tggcttgaa  cttttccct  cattaataa  gttttgcaa  tcatcattg  1200
tgcctgtct  gtggaggtg  tctattagc  tcacaagca  aaaaaaagt  agcgtcttc  1260
ttatttata  tttacaaaa  gccaaatta  ttcagcata  tccggtgat  actttaaaa  1320
ttagataca  tttcttaac  tttttttct  ttttaatgt  atgataatg  acttcaaaa  1380
gatggaaat  tcaacagta  gagtatggc  tggttaacg  gcagtatgt  cacagcctg  1440
tttatctct  cttgctctt  tcacctctc  cttaccccg  tccctattt  cgtgttctt  1500
cctagcctc  ccccacttc  tcaaaacaa  caagagatg  caaagcagc  gtccgacca  1560
gcccactgg  attatcctt  aattttaca  ataccactt  ctgtaggct  tggaccaag  1620
tgtccagaa  tattcttga  cactgatgt  aattactta  atcttcttt  aggtcagaa  1680
tcagcgatc  cggtaggca  tgcttgaat  agaaaagcc  cctggtgca  cttcaaaat  1740
agtcctaaa  aacatactg  gtacttata  gtagcagaa  ataaaatgt  tttctgact  1800
acacaaatg  tcctttcac  tgtgcttta  tagactctg  gagagaaaa  taaccaagt  1860
cttcagaac  ggtttttag  atttacttc  tcatggtaa  ataatgaag  tctaatgaa  1920
tatttctcc  aaggtttta  aattgtcaa  agttattct  tttgtttaa  aagtaagaa  1980
cctctgtaa  caatagatt  tgcttgggt  ttctttctt  aaaaaataa  actatgcag  2040
caagacacc  taaaagttt  attccttac  gaagaacca  tggaagaat  taaatttgg  2100
actacgatc  aaactactg  attagcaga  ataacgata  ctaaagctt  ccagcaaaa  2160
aaccctcag  agaatagca  aaactttgc  caggacatt  gaggtcaaa  tgaagacgg  2220
agacggaaa  cggaaaccg  tttcttgta  gcccctaga  gcagatcag  taagcatac  2280
tagtagagg  aaaggagag  atggaaata  aactgaata  tatgcagat  tatgcctta  2340
tttttagca  tttttaagg  tgggtcttt  aggctggtt  tggtttgta  tagatctgt  2400
tagtttagt  atttagttt  atatttaag  tacgattaa  attttttct  tggcgatat  2460
tctttgctt  tttttttta  caactttcc  tttttagat  tttcgttga  tctatttag  2520
gcttcacca  ggcaatatg  atttccctt  aaacactgc  aacaaatat  ctaggagtg  2580
gccctttta  tctttacta  ttattgtga  actgctgtg  aagctaata  acacatttg  2640
aaaaacatt  tttgcagga  gaaaacttc  agttacagg  caggaaaag  ctgctgaat  2700
tatgttgta  acgttactt  acacagtat  aagatgaaa  gacaacaaa  gtatcttca  2760
acttcctca  cccctcatt  caacaaaac  ttaaactgg  agaacctta  tcccctctc  2820
ttcctcttc  tcctccact  cccacttat  gccactttg  aatattcag  gagcacttg  2880
attatggat  tgaatagag  aatgcttac  gataatcat  agcccacat  ccagtaact  2940
atacttaaa  atgggatgg  gttataaag  gcttttata  tccaatata  ttgctaaag  3000
caagggttg  ctctttgtt  tattttgac  tggcatgtc  tgaaataaa  attggttca  3060
tatgaaaaa  aaaaaaaaa  aaaa  3084



<210> 4521
<211> 208
<212> PRT
<213> Homo sapiens
<308> AAH03617
<400> 4521

Met Ser Thr Gly Gly Asp Phe Gly Asn Pro Leu Arg Lys Phe Lys Leu 
  1               5                  10                  15
Val Phe Leu Gly Glu Gln Ser Val Gly Lys Thr Ser Leu Ile Thr Arg 
             20                  25                  30
Phe Met Tyr Asp Ser Phe Asp Asn Thr Tyr Gln Ala Thr Ile Gly Ile 
         35                  40                  45
Asp Phe Leu Ser Lys Thr Met Tyr Leu Glu Asp Arg Thr Ile Arg Leu 
     50                  55                  60
Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Leu Ile Pro 
 65                  70                  75                  80
Ser Tyr Ile Arg Asp Ser Ala Ala Ala Val Val Val Tyr Asp Ile Thr 
                 85                  90                  95
Asn Val Asn Ser Phe Gln Gln Thr Thr Lys Trp Ile Asp Asp Val Arg 
             100                105                110
Thr Glu Arg Gly Ser Asp Val Ile Ile Met Leu Val Gly Asn Lys Thr 
         115                120                125
Asp Leu Ala Asp Lys Arg Gln Val Ser Ile Glu Glu Gly Glu Arg Lys 
     130                135                140
Ala Lys Glu Leu Asn Val Met Phe Ile Glu Thr Ser Ala Lys Ala Gly 
 145                150                155                160
Tyr Asn Val Lys Gln Leu Phe Arg Arg Val Ala Ala Ala Leu Pro Gly 
                 165                170                175
Met Glu Ser Thr Gln Asp Arg Ser Arg Glu Asp Met Ile Asp Ile Lys 
             180                185                190
Leu Glu Lys Pro Gln Glu Gln Pro Val Ser Glu Gly Gly Cys Ser Cys 
         195                200                205



<210> 4522
<211> 582
<212> DNA
<213> Rattus norvegicus
<308> AA799804
<400> 4522

aacgatcaa  aaacacttt  cacttataa  taaacgctt  tttgatcaa  attaaatga  60
aactaccca  aaccttaca  gcctttcag  aggcggcag  catgatgtt  ggaagatag  120
tgttagctt  ctgtgatca  aaggatagc  ctttgctgt  atttattta  aatgtacct  180
acagcttcc  tcacagtaa  ttgactgaa  ttacaacag  aaaagaaac  cagcattta  240
tcctaggtt  agacataac  cacacaaag  tccaactat  tggcttcta  actttttcg  300
gaaggtgcg  aaaagaaat  cggatctca  tttagacca  gaatttcag  tgcaataag  360
caacctctg  agtccaaag  tcaatgaat  cacaacagt  caagcagca  ataccacct  420
agaggaaat  tttagtttg  ttctttgtt  ccctccagt  ttaatcctg  taatgtctg  480
taaggtcaa  catgactgg  acacatgct  ctgatccag  tgttcaaga  cagcctggg  540
aacacggcg  gacactgcc  cagaacaag  agtgaaaac  ga  582



<210> 4523
<211> 475
<212> DNA
<213> Rattus norvegicus
<308> AA799814
<400> 4523

agtaaagac  attttgttc  tacaaaaca  cagtttaca  cagtctgag  gttgaacac  60
ccatcaagg  catgggagg  gctgcagac  tctgggccc  gccccaggc  cagagatgc  120
caggagccc  tcctccacc  acccctgag  gagacaccc  tcctccagc  cgaggggca  180
gggggacca  ggcacaaag  ctcgtcccc  actgctccg  ctcaatcct  gggagcccc  240
acccaggtt  agtagttag  gggtaaggt  gctggtggg  agggacaga  tcaagacat  300
tttggtgcg  agactgtcc  acccaccag  ccccgtgct  gaaatcgag  agaccacac  360
tggtcctgc  cttgccaaa  ggaggttgg  aagtacccc  tagttcagg  gagatgcat  420
aaatgcaac  gcctttctg  gtagataac  ttcccaggg  cacccatgg  actgg  475



<210> 4524
<211> 2258
<212> DNA
<213> Homo sapiens
<308> U12779
<400> 4524

gatatcaca  caacattga  atgctaaaa  gtttttaaa  actctcaat  tctaattca  60
catgtcaca  actggtgaa  aaaaaaaaa  aagcggccg  ttccccccg  ccgggcccc  120
gccgccccg  ggtccccag  gcgccaggc  cccgggggg  gggagggag  gcgccgggc  180
ggtgggagc  agcggcgcg  ggtgggacc  acggagccc  gcgacccgc  gagcctgga  240
ccgggccgg  tcggggaag  cggctccag  ccggagcga  cttcgcagc  cgtcggggg  300
cggcgggga  ggggcccgg  gccggagga  ggggcggcc  cgggcaccc  cgcctgtgc  360
ccggcgtcc  cgggcacca  gctgtccaa  tcccagggc  agagcccgc  ggtgccgtt  420
cccgccccg  ccccgccgc  gcagccccc  acccctgcc  tgccgcacc  cccggcgca  480
ccgccgccg  cgcccccgc  gcagttccc  cagttccac  tcaagtccg  cctgcagat  540
aagaagaac  ccatcatcg  tgactacaa  gtcaccagc  aggtcctgg  gctgggcat  600
aacggcaaa  ttttgcaga  cttcaacaa  aggacccag  agaaattcg  cctcaaaat  660
cttcaggac  gccccaagg  ccgcaggga  gtggagctg  actggcggg  ctcccagtg  720
ccgcacatc  tacggatcg  ggatgtgta  gagaatctg  acgcaggga  gaagtgcct  780
ctgattgtc  tggaatgtt  ggacggtgg  gaactcttt  gccgaatcc  ggatcgagg  840
gaccaggca  tcacagaaa  agaagcatc  gaaatcatg  agagcatcg  tgaggccat  900
cagtatctg  attcaatca  cattgccca  cgggatgtc  agcctgaga  tctcttata  960
acctccaaa  ggcccaacg  catcctgaa  ctcactgac  ttggctttg  caaggaaac  1020
accagccac  actctttga  cactccttg  tatacaccg  actatgtgg  tccagaagt  1080
ctgggtcca  agaagtatg  caagtcctg  gacatgtgg  ccctgggtg  catcatgta  1140
atcctgctg  gtgggtatc  ccccttcta  tccaaccac  gccttgcca  ctctccggg  1200
atgaagact  gcatccgaa  gggccagta  gaatttccc  acccagaat  gtcagaagt  1260
tcagaggaa  tgaagatgc  cattcggaa  ctgctgaaa  cagagccca  ccagagaat  1320
accatcacc  agtttatga  ccacccttg  atcatgcaa  caacaaagg  ccctcaaac  1380
ccactgcac  ccagccggg  cctgaagga  gacaaggag  ggtgggagg  tgtcaaggg  1440
tgtcttcat  acaagaaca  cgaccaggc  acttggctg  ccaggttgt  agcagagga  1500
tctgtgttc  tgtccaaac  cagtgctgt  tcttagaat  cttttattc  ctgggtctc  1560
aatgggacc  taaagacca  ctggtatca  cttctcatt  tgcagaaga  aaactgagg  1620
ccagaggcg  agggcagtc  gctcaaggt  acgcagctg  tgactggtt  gggcagacc  1680
gacccaggt  tcctgactc  tggcccaag  ctcttcctc  tatcctgcg  gatcactgg  1740
gggctctca  ggaacagca  cagtgccat  gccaggctc  ctgctgccc  gcgctgggg  1800
gaggctgcc  ttgtcagcg  ggaccacta  ccagcccgt  ttctctctc  gctcccacc  1860
ctgccgcct  acctgccct  gttgtctct  tctctcact  tctcttctg  tgtctctct  1920
ctgtcttct  gctctctct  tacccttcc  ggtgctgcc  tgcccccag  aggagatga  1980
cagtgcctt  gccacaatg  gcgttgact  cgagcagat  aagataaaa  agattgaag  2040
tgcatccaa  cctctgctg  tgaagaggc  gaagaaagc  cgggccctg  aggctgcgg  2100
tctggccca  tgagccacc  cgccctcct  cccacggga  gacaagcaa  aactctcta  2160
aggaatata  tttttaaac  aagagacag  actgtccac  tctgcctcc  ctcctcctc  2220
gctgcatgg  gcctggaac  gcatcagtg  ctgaattc  2258



<210> 4525
<211> 400
<212> PRT
<213> Homo sapiens
<308> P49137
<400> 4525

Met Leu Ser Asn Ser Gln Gly Gln Ser Pro Pro Val Pro Phe Pro Ala 
  1               5                  10                  15
Pro Ala Pro Pro Pro Gln Pro Pro Thr Pro Ala Leu Pro His Pro Pro 
             20                  25                  30
Ala Gln Pro Pro Pro Pro Pro Pro Gln Gln Phe Pro Gln Phe His Val 
         35                  40                  45
Lys Ser Gly Leu Gln Ile Lys Lys Asn Ala Ile Ile Asp Asp Tyr Lys 
     50                  55                  60
Val Thr Ser Gln Val Leu Gly Leu Gly Ile Asn Gly Lys Val Leu Gln 
 65                  70                  75                  80
Ile Phe Asn Lys Arg Thr Gln Glu Lys Phe Ala Leu Lys Met Leu Gln 
                 85                  90                  95
Asp Cys Pro Lys Ala Arg Arg Glu Val Glu Leu His Trp Arg Ala Ser 
             100                105                110
Gln Cys Pro His Ile Val Arg Ile Val Asp Val Tyr Glu Asn Leu Tyr 
         115                120                125
Ala Gly Arg Lys Cys Leu Leu Ile Val Met Glu Cys Leu Asp Gly Gly 
     130                135                140
Glu Leu Phe Ser Arg Ile Gln Asp Arg Gly Asp Gln Ala Phe Thr Glu 
 145                150                155                160
Arg Glu Ala Ser Glu Ile Met Lys Ser Ile Gly Glu Ala Ile Gln Tyr 
                 165                170                175
Leu His Ser Ile Asn Ile Ala His Arg Asp Val Lys Pro Glu Asn Leu 
             180                185                190
Leu Tyr Thr Ser Lys Arg Pro Asn Ala Ile Leu Lys Leu Thr Asp Phe 
         195                200                205
Gly Phe Ala Lys Glu Thr Thr Ser His Asn Ser Leu Thr Thr Pro Cys 
     210                215                220
Tyr Thr Pro Tyr Tyr Val Ala Pro Glu Val Leu Gly Pro Glu Lys Tyr 
 225                230                235                240
Asp Lys Ser Cys Asp Met Trp Ser Leu Gly Val Ile Met Tyr Ile Leu 
                 245                250                255
Leu Cys Gly Tyr Pro Pro Phe Tyr Ser Asn His Gly Leu Ala Ile Ser 
             260                265                270
Pro Gly Met Lys Thr Arg Ile Arg Met Gly Gln Tyr Glu Phe Pro Asn 
         275                280                285
Pro Glu Trp Ser Glu Val Ser Glu Glu Val Lys Met Leu Ile Arg Asn 
     290                295                300
Leu Leu Lys Thr Glu Pro Thr Gln Arg Met Thr Ile Thr Glu Phe Met 
 305                310                315                320
Asn His Pro Trp Ile Met Gln Ser Thr Lys Val Pro Gln Thr Pro Leu 
                 325                330                335
His Thr Ser Arg Val Leu Lys Glu Asp Lys Glu Arg Trp Glu Asp Val 
             340                345                350
Lys Glu Glu Met Thr Ser Ala Leu Ala Thr Met Arg Val Asp Tyr Glu 
         355                360                365
Gln Ile Lys Ile Lys Lys Ile Glu Asp Ala Ser Asn Pro Leu Leu Leu 
     370                375                380
Lys Arg Arg Lys Lys Ala Arg Ala Leu Glu Ala Ala Ala Leu Ala His 
 385                390                395                400



<210> 4526
<211> 610
<212> DNA
<213> Rattus norvegicus
<308> AA799822
<400> 4526

gacgttctc  accaatccc  ttatttact  acgacaaca  tctaaaggc  gatatgccc  60
ttttgatga  cccagccca  cttccccat  cctacaaat  ctgcaccct  taggaccca  120
ggaactaca  ctaacctgt  agttgattt  aggaagcct  gcaggggcc  atggttaga  180
tgtaccttg  tccccacat  caggaccaa  aattccagc  cctgccttt  acaccaacg  240
gtaatatgg  gtacccagg  gctgcaagt  cagaacaga  gcagccaaa  acaggttgt  300
tccaaggcg  gcaaacctg  gggcagcgg  actgctcag  ctacagagg  ctgggatga  360
cacacccct  cactgtgct  actactttg  caaaagaac  aaatcacca  gagttttaa  420
aacatgagt  aacttcagg  gacagaaaa  taaaacagc  gcctgtaca  aggctcaag  480
ctgcccagt  agccgcact  cctgcttgc  gccagcttc  tcactgcgg  aggatgtaa  540
cgtttgctg  cagcagcca  agtgactga  tcaggctcc  tttgttagc  accgtgact  600
tcccttggag  610



<210> 4527
<211> 196
<212> PRT
<213> Rattus norvegicus
<308> AAH10524
<400> 4527

Met Asp Asp Thr Leu Phe Gln Leu Lys Phe Thr Ala Lys Gln Leu Glu 
  1               5                  10                  15
Lys Leu Ala Lys Lys Ala Glu Lys Asp Ser Lys Ala Glu Gln Ala Lys 
             20                  25                  30
Val Lys Lys Ala Leu Gln Gln Lys Asn Val Glu Cys Ala Arg Val Tyr 
         35                  40                  45
Ala Glu Asn Ala Ile Arg Lys Lys Asn Glu Gly Val Asn Trp Leu Arg 
     50                  55                  60
Met Ala Ser Arg Val Asp Ala Val Ala Ser Lys Val Gln Thr Ala Val 
 65                  70                  75                  80
Thr Met Lys Gly Val Thr Lys Asn Met Ala Gln Val Thr Lys Ala Leu 
                 85                  90                  95
Asp Lys Ala Leu Ser Ala Met Asp Leu Gln Lys Val Ser Ala Val Met 
             100                105                110
Asp Arg Phe Glu Gln Gln Val Gln Asn Leu Asp Val His Thr Ser Val 
         115                120                125
Met Glu Asp Ser Val Ser Ser Ala Thr Thr Leu Thr Thr Pro Gln Glu 
     130                135                140
Gln Val Asp Ser Leu Ile Val Gln Ile Ala Glu Glu Asn Gly Leu Glu 
 145                150                155                160
Val Leu Asp Gln Leu Ser Gln Leu Pro Glu Gly Ala Ser Ala Val Gly 
                 165                170                175
Glu Ser Ser Val Arg Ser Gln Glu Asp Gln Leu Ser Arg Arg Leu Ala 
             180                185                190
Ala Leu Arg Asn 
         195



<210> 4528
<211> 610
<212> DNA
<213> Rattus norvegicus
<308> AA799822
<400> 4528

gacgttctc  accaatccc  ttatttact  acgacaaca  tctaaaggc  gatatgccc  60
ttttgatga  cccagccca  cttccccat  cctacaaat  ctgcaccct  taggaccca  120
ggaactaca  ctaacctgt  agttgattt  aggaagcct  gcaggggcc  atggttaga  180
tgtaccttg  tccccacat  caggaccaa  aattccagc  cctgccttt  acaccaacg  240
gtaatatgg  gtacccagg  gctgcaagt  cagaacaga  gcagccaaa  acaggttgt  300
tccaaggcg  gcaaacctg  gggcagcgg  actgctcag  ctacagagg  ctgggatga  360
cacacccct  cactgtgct  actactttg  caaaagaac  aaatcacca  gagttttaa  420
aacatgagt  aacttcagg  gacagaaaa  taaaacagc  gcctgtaca  aggctcaag  480
ctgcccagt  agccgcact  cctgcttgc  gccagcttc  tcactgcgg  aggatgtaa  540
cgtttgctg  cagcagcca  agtgactga  tcaggctcc  tttgttagc  accgtgact  600
tcccttggag  610



<210> 4529
<211> 196
<212> PRT
<213> Rattus norvegicus
<308> AAH10524
<400> 4529

Met Asp Asp Thr Leu Phe Gln Leu Lys Phe Thr Ala Lys Gln Leu Glu 
  1               5                  10                  15
Lys Leu Ala Lys Lys Ala Glu Lys Asp Ser Lys Ala Glu Gln Ala Lys 
             20                  25                  30
Val Lys Lys Ala Leu Gln Gln Lys Asn Val Glu Cys Ala Arg Val Tyr 
         35                  40                  45
Ala Glu Asn Ala Ile Arg Lys Lys Asn Glu Gly Val Asn Trp Leu Arg 
     50                  55                  60
Met Ala Ser Arg Val Asp Ala Val Ala Ser Lys Val Gln Thr Ala Val 
 65                  70                  75                  80
Thr Met Lys Gly Val Thr Lys Asn Met Ala Gln Val Thr Lys Ala Leu 
                 85                  90                  95
Asp Lys Ala Leu Ser Ala Met Asp Leu Gln Lys Val Ser Ala Val Met 
             100                105                110
Asp Arg Phe Glu Gln Gln Val Gln Asn Leu Asp Val His Thr Ser Val 
         115                120                125
Met Glu Asp Ser Val Ser Ser Ala Thr Thr Leu Thr Thr Pro Gln Glu 
     130                135                140
Gln Val Asp Ser Leu Ile Val Gln Ile Ala Glu Glu Asn Gly Leu Glu 
 145                150                155                160
Val Leu Asp Gln Leu Ser Gln Leu Pro Glu Gly Ala Ser Ala Val Gly 
                 165                170                175
Glu Ser Ser Val Arg Ser Gln Glu Asp Gln Leu Ser Arg Arg Leu Ala 
             180                185                190
Ala Leu Arg Asn 
         195



<210> 4530
<211> 630
<212> DNA
<213> Rattus norvegicus
<308> AA799824
<400> 4530

caccgtgca  aggttcttt  attctgtcc  gtgggtgtc  acagtgctg  caggatagt  60
ttggaacat  cggaaagca  acacctgaa  gttgttaca  tgcactaca  cacaacttg  120
taactactg  acagttatg  ctactaata  agtgaatga  acatctgct  acaccattc  180
ctgtaaaca  ggctgtgca  tacagtaac  caggattat  cataccatg  tatcaagga  240
gaaaatacc  ctttaaata  actattcta  ttataaata  actctgatt  tctcagtac  300
catttacag  cctgatcaa  aaaaagaaa  aatatatat  tatatattt  tttttcttt  360
aaaagcaaa  gttgagata  ggaccacat  gaaatccac  tggggaagg  tagggagca  420
gcatggggc  ggagagtta  gagttaact  tgtgagcac  caccaacac  aggacagga  480
tgactggga  gagcttgtt  ttacttgaa  tccagcaag  tgcaatcaa  cttgtagta  540
acatagggg  agtattctt  ctgactcag  ttcaggcca  gaatatcca  aggagcatc  600
atgatggca  ctgcactgc  gtccagatgc  630



<210> 4531
<211> 382
<212> PRT
<213> Rattus norvegicus
<308> AAC83084
<400> 4531

Met Thr Glu Phe Trp Leu Ile Ser Ala Pro Gly Glu Lys Thr Cys Gln 
  1               5                  10                  15
Gln Thr Trp Glu Lys Leu His Ala Ala Thr Thr Lys Asn Asn Asn Leu 
             20                  25                  30
Ala Val Ser Ser Lys Phe Asn Ile Pro Asp Leu Lys Val Gly Thr Leu 
         35                  40                  45
Asp Val Leu Val Gly Leu Ser Asp Glu Leu Ala Lys Leu Asp Ala Phe 
     50                  55                  60
Val Glu Gly Val Val Lys Lys Val Ala Gln Tyr Met Ala Asp Val Leu 
 65                  70                  75                  80
Glu Asp Ser Lys Asp Lys Val Gln Glu Asn Leu Leu Ala Ser Gly Val 
                 85                  90                  95
Asp Leu Val Thr Tyr Ile Thr Arg Phe Gln Trp Asp Met Ala Lys Tyr 
             100                105                110
Pro Ile Lys Gln Ser Leu Lys Asn Ile Ser Glu Ile Ile Ala Lys Gly 
         115                120                125
Val Thr Gln Ile Asp Asn Asp Leu Lys Ser Arg Ala Ser Ala Tyr Asn 
     130                135                140
Asn Leu Lys Gly Asn Leu Gln Asn Leu Glu Arg Lys Asn Ala Gly Ser 
 145                150                155                160
Leu Leu Thr Arg Ser Leu Ala Glu Ile Val Lys Lys Asp Asp Phe Val 
                 165                170                175
Leu Asp Ser Glu Tyr Leu Val Thr Leu Leu Val Val Val Pro Lys Leu 
             180                185                190
Asn His Asn Asp Trp Ile Lys Gln Tyr Glu Thr Leu Ala Glu Met Val 
         195                200                205
Val Pro Arg Ser Ser Asn Val Leu Ser Glu Asp Gln Asp Ser Tyr Leu 
     210                215                220
Cys Asn Val Thr Leu Phe Arg Lys Ala Val Asp Asp Phe Arg His Lys 
 225                230                235                240
Ala Arg Glu Asn Lys Phe Ile Val Arg Asp Phe Gln Tyr Asn Glu Glu 
                 245                250                255
Glu Met Lys Ala Asp Lys Glu Glu Met Thr Glu Leu Ser Thr Asp Lys 
             260                265                270
Lys Lys Gln Phe Gly Pro Leu Val Arg Trp Leu Lys Val Asn Phe Ser 
         275                280                285
Glu Ala Phe Ile Ala Trp Ile His Ile Lys Ala Leu Arg Val Phe Val 
     290                295                300
Glu Ser Val Leu Arg Tyr Gly Leu Pro Val Asn Phe Gln Ala Met Leu 
 305                310                315                320
Leu Gln Pro Asn Lys Lys Ser Val Lys Lys Leu Arg Glu Val Leu His 
                 325                330                335
Glu Leu Tyr Lys His Leu Asp Ser Ser Ala Ala Ala Ile Ile Asp Ala 
             340                345                350
Pro Met Asp Ile Pro Gly Leu Asn Leu Ser Gln Gln Glu Tyr Tyr Pro 
         355                360                365
Tyr Val Tyr Tyr Lys Ile Asp Cys Asn Leu Leu Glu Phe Lys 
     370                375                380



<210> 4532
<211> 1618
<212> DNA
<213> Homo sapiens
<308> J05682
<400> 4532

tccaagttc  atattcctg  cttaaaggt  ggcacgttg  atgtcttgg  tggcttgtc  60
gacgaactg  ctaaactgg  tgcatttgt  gaaggagtg  ttaagaaag  agctcaata  120
atggctgat  tattggaag  tagcaaaga  aaagttcaa  agaatctgt  ggctaatgg  180
gtggacttg  ttacttata  aacaaggtt  cagtgggac  tggccaaat  tccaatcaa  240
cagtccctg  aaaatattt  tgaaataat  gccaaggga  taactcaga  tgataatga  300
ctgaaatct  gagcatctg  atacaataa  ctgaaagga  atcttcaga  tttggaacg  360
aagaatgca  gaagtttgc  aactagaag  ctagcagaa  ttgtgaaga  ggatgactt  420
gttcttgat  cagagtatc  cgtcacatt  ctggtagta  ttcccaagt  aaaccacaa  480
gactggatt  agcagtatg  aacactagc  gaaatggta  ttccaaggt  tagcaatgt  540
ctttcagag  accaagaca  ttacctgtg  aatgtcacc  tgtttagga  ggcagttga  600
gacttcaga  acaaagcca  agaaaacaa  ttcattgtt  gtgacttcc  gtataatga  660
gaggagatg  aagcagata  agaagaaat  aacaggctt  ctactgata  gaaaaaaca  720
tttggacca  ttgtacggt  gctgaaagt  aattttagt  aagcattta  tgcatggat  780
cacgtgaaa  cattacggg  tttcgttga  tctgtttta  ggtatggct  gccagtgaa  840
ttccaagca  tgctacttc  gcccaataa  aaaactttg  agaaactga  agaagtatt  900
catgaattg  ataaacatc  agacagcag  gcagcagct  ttattgatg  tcctatgga  960
attccaggt  taaacctga  tcaacaaga  tactacccc  atgtgtact  caagattga  1020
tgcaacttg  tggaattca  gtgaaaatg  gctccttcc  cgacaatcc  gtccttgtg  1080
ttgtgtgtg  taacagaaa  aagttgcag  atggtcgta  ttttaactc  agtatcctt  1140
gcttgcttc  taccccctt  cctaggtga  ttctcccac  gtggtctgt  tctcaacat  1200
ttcttttta  aggaaaaaa  atatatata  agtttcttt  tattgatca  gtctgtaaa  1260
gtgtactaa  aaaatcaga  tttatttat  aacagaata  tttatttaa  gagaaggtc  1320
cttccttat  gatatcatg  tatgcatta  ttccatttg  tactattgt  cacaaaagc  1380
ctgttcaca  gggaatggt  taaaaattt  tactgtttt  ttcactgta  ttagtagac  1440
taactgttg  atagttact  aatcatgat  taaagaata  gtgaccatc  tcaggtatg  1500
gatttctga  cgtttcaaa  ttcaatcaa  gagcactgt  aacacccac  ggagagaat  1560
aaattacct  tgcaaaggt  tattgtggt  tgtgtaact  aagattaca  tggaattc  1618



<210> 4533
<211> 382
<212> PRT
<213> Homo sapiens
<308> P21283
<400> 4533

Met Thr Glu Phe Trp Leu Ile Ser Ala Pro Gly Glu Lys Thr Cys Gln 
  1               5                  10                  15
Gln Thr Trp Glu Lys Leu His Ala Ala Thr Ser Lys Asn Asn Asn Leu 
             20                  25                  30
Ala Val Thr Ser Lys Phe Asn Ile Pro Asp Leu Lys Val Gly Thr Leu 
         35                  40                  45
Asp Val Leu Val Gly Leu Ser Asp Glu Leu Ala Lys Leu Asp Ala Phe 
     50                  55                  60
Val Glu Gly Val Val Lys Lys Val Ala Gln Tyr Met Ala Asp Val Leu 
 65                  70                  75                  80
Glu Asp Ser Lys Asp Lys Val Gln Glu Asn Leu Leu Ala Asn Gly Val 
                 85                  90                  95
Asp Leu Val Thr Tyr Ile Thr Arg Phe Gln Trp Asp Met Ala Lys Tyr 
             100                105                110
Pro Ile Lys Gln Ser Leu Lys Asn Ile Ser Glu Ile Ile Ala Lys Gly 
         115                120                125
Val Thr Gln Ile Asp Asn Asp Leu Lys Ser Arg Ala Ser Ala Tyr Asn 
     130                135                140
Asn Leu Lys Gly Asn Leu Gln Asn Leu Glu Arg Lys Asn Ala Gly Ser 
 145                150                155                160
Leu Leu Thr Arg Ser Leu Ala Glu Ile Val Lys Lys Asp Asp Phe Val 
                 165                170                175
Leu Asp Ser Glu Tyr Leu Val Thr Leu Leu Val Val Val Pro Lys Leu 
             180                185                190
Asn His Asn Asp Trp Ile Lys Gln Tyr Glu Thr Leu Ala Glu Met Val 
         195                200                205
Val Pro Arg Ser Ser Asn Val Leu Ser Glu Asp Gln Asp Ser Tyr Leu 
     210                215                220
Cys Asn Val Thr Leu Phe Arg Lys Ala Val Asp Asp Phe Arg His Lys 
 225                230                235                240
Ala Arg Glu Asn Lys Phe Ile Val Arg Asp Phe Gln Tyr Asn Glu Glu 
                 245                250                255
Glu Met Lys Ala Asp Lys Glu Glu Met Asn Arg Leu Ser Thr Asp Lys 
             260                265                270
Lys Lys Gln Phe Gly Pro Leu Val Arg Trp Leu Lys Val Asn Phe Ser 
         275                280                285
Glu Ala Phe Ile Ala Trp Ile His Val Lys Ala Leu Arg Val Phe Val 
     290                295                300
Glu Ser Val Leu Arg Tyr Gly Leu Pro Val Asn Phe Gln Ala Met Leu 
 305                310                315                320
Leu Gln Pro Asn Lys Lys Thr Leu Lys Lys Leu Arg Glu Val Leu His 
                 325                330                335
Glu Leu Tyr Lys His Leu Asp Ser Ser Ala Ala Ala Ile Ile Asp Ala 
             340                345                350
Pro Met Asp Ile Pro Gly Leu Asn Leu Ser Gln Gln Glu Tyr Tyr Pro 
         355                360                365
Tyr Val Tyr Tyr Lys Ile Asp Cys Asn Leu Leu Glu Phe Lys 
     370                375                380



<210> 4534
<211> 427
<212> DNA
<213> Rattus norvegicus
<308> AA799854
<400> 4534

actgggact  tccccatca  tgcaaatcg  ttattgtgt  ggtttccat  gtggctggg  60
tcatgggac  gctttggct  cagagctag  gatctggtc  gggcaaagc  gctctgcag  120
ccttgggct  caggagcaa  aaggcacaa  gtgagacct  catcaggta  gcaccacag  180
gtagggagg  gatgtgcct  ctgtgccag  gtgcaggga  tggaaaagc  ttcgtcagc  240
caggacctg  tggaattgt  actgctgtt  gtgttttta  aaagaaaga  aacgtcctg  300
acctcgtcc  tgtctacgt  tcccagagc  agaaagtcg  acgtgactg  atagtcgta  360
tccagcctc  acttgtcct  agaggacgg  cggtctggg  atgggatga  gaaagagag  420
acaaaca  427



<210> 4535
<211> 207
<212> DNA
<213> Rattus norvegicus
<308> AA799858
<400> 4535

aaaaattca  agtcttctt  attgcaaaa  atatgtctt  gacctgagg  aaggagttg  60
cttccaaaa  ctttgcgta  gggaaaggg  aatcagcac  agtgaccca  aaagcaggc  120
catcaagga  ttttaatgc  gggccttcc  aaattcccg  aaaaatctc  gccccgacc  180
caaattggg  gcaaccccc  tccaaag  207



<210> 4536
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> P49432
<400> 4536

Met Ala Gly Val Ala Gly Leu Val Arg Gly Leu Cys Gly Arg Leu Ser 
  1               5                  10                  15
Gly Leu Leu Lys Arg Leu Phe His Cys Ser Ala Pro Ala Ala Val Gln 
             20                  25                  30
Leu Thr Val Arg Glu Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
         35                  40                  45
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
     50                  55                  60
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
 65                  70                  75                  80
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                 85                  90                  95
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
             100                105                110
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
         115                120                125
Lys Thr Tyr Tyr Met Ser Ala Gly Leu Gln Pro Val Pro Ile Val Phe 
     130                135                140
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
 145                150                155                160
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                 165                170                175
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
             180                185                190
Asp Asp Asn Pro Val Val Met Leu Glu Asn Glu Leu Met Tyr Gly Val 
         195                200                205
Ala Phe Glu Leu Pro Thr Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
     210                215                220
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Asn Val Val 
 225                230                235                240
Cys Tyr Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                 245                250                255
Ser Lys Gly Gly Ile Glu Cys Glu Val Ile Asn Leu Arg Thr Ile Arg 
             260                265                270
Pro Met Asp Ile Glu Ala Ile Glu Ala Ser Val Met Lys Thr Asn His 
         275                280                285
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
     290                295                300
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
 305                310                315                320
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                 325                330                335
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
             340                345                350
Ile Lys Lys Thr Leu Asn Ile 
         355



<210> 4537
<211> 359
<212> PRT
<213> Homo sapiens
<308> BC000439
<400> 4537

Met Ala Ala Val Ser Gly Leu Val Arg Arg Pro Leu Arg Glu Val Ser 
  1               5                  10                  15
Gly Leu Leu Lys Arg Arg Phe His Trp Thr Ala Pro Ala Ala Val Gln 
             20                  25                  30
Val Thr Val Arg Asp Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
         35                  40                  45
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
     50                  55                  60
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
 65                  70                  75                  80
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                 85                  90                  95
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
             100                105                110
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
         115                120                125
Lys Thr Tyr Tyr Met Ser Gly Gly Leu Gln Pro Val Pro Ile Val Phe 
     130                135                140
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
 145                150                155                160
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                 165                170                175
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
             180                185                190
Asp Asn Asn Pro Val Val Val Leu Glu Asn Glu Leu Met Tyr Gly Val 
         195                200                205
Pro Phe Glu Phe Pro Pro Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
     210                215                220
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Thr Val Val 
 225                230                235                240
Ser His Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                 245                250                255
Ser Lys Glu Gly Val Glu Cys Glu Val Ile Asn Met Arg Thr Ile Arg 
             260                265                270
Pro Met Asp Met Glu Thr Ile Glu Ala Ser Val Met Lys Thr Asn His 
         275                280                285
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
     290                295                300
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
 305                310                315                320
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                 325                330                335
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
             340                345                350
Ile Lys Lys Thr Leu Asn Ile 
         355



<210> 4538
<211> 499
<212> DNA
<213> Rattus norvegicus
<308> AA799861
<400> 4538

ggtaaccca  ccaattctt  attgtaaag  tgagtgcta  aaaggaggc  tagtgtgta  60
ggagtgggg  gtcaccttc  ttcaaggga  tccacaagg  ccactagag  tgacatata  120
ccaaggaat  agcctgagc  agggcagca  tggttctga  ctctattgg  agttggggt  180
ctgaatcaa  cccactgac  caggtccat  aggaagtgt  caatgtcat  gtagagact  240
ttggtgcta  acaagcaca  gccaagact  ctgctgtcc  gagaggaca  accctcacg  300
tgcacgcct  ccagatgtg  cttgcacag  catggctcc  gcttcacca  gatcaggct  360
ttctccttg  gcctccctg  tgacaagtc  tgcccaaaa  ccaggtaga  ggtgtaatg  420
ggtgatcct  gtcgcctcc  ggcccggaa  tcctccagt  ctcggaaga  atgctgaag  480
caaagatgg  agtatggca  499



<210> 4539
<211> 457
<212> PRT
<213> Rattus norvegicus
<308> NP_058546
<400> 4539

Met Ala Glu Val Arg Gly Val Gln Arg Val Leu Phe Gly Asp Trp Leu 
  1               5                  10                  15
Leu Gly Glu Val Ser Ser Gly Gln Tyr Glu Gly Leu Gln Trp Leu Asn 
             20                  25                  30
Glu Ala Arg Thr Val Phe Arg Val Pro Trp Lys His Phe Gly Arg Arg 
         35                  40                  45
Asp Leu Asp Glu Glu Asp Ala Gln Ile Phe Lys Ala Trp Ala Val Ala 
     50                  55                  60
Arg Gly Arg Trp Pro Pro Ser Gly Val Asn Leu Pro Pro Pro Glu Ala 
 65                  70                  75                  80
Glu Ala Ala Glu Arg Arg Glu Arg Arg Gly Trp Lys Thr Asn Phe Arg 
                 85                  90                  95
Cys Ala Leu His Ser Thr Gly Arg Phe Ile Leu Arg Gln Asp Asn Ser 
             100                105                110
Gly Asp Pro Val Asp Pro His Lys Val Tyr Glu Leu Ser Arg Glu Leu 
         115                120                125
Gly Ser Thr Val Gly Pro Ala Thr Glu Asn Arg Glu Glu Val Ser Leu 
     130                135                140
Ser Asn Ala Leu Pro Thr Gln Gly Val Ser Pro Gly Ser Phe Leu Ala 
 145                150                155                160
Arg Glu Asn Ala Gly Leu Gln Thr Pro Ser Pro Leu Leu Ser Ser Asp 
                 165                170                175
Ala Gly Asp Leu Leu Leu Gln Val Leu Gln Tyr Ser His Ile Leu Glu 
             180                185                190
Ser Glu Ser Gly Ala Asp Pro Val Pro Pro Gln Ala Pro Gly Gln Glu 
         195                200                205
Gln Asp Arg Val Tyr Glu Glu Pro Tyr Ala Ala Trp Gln Val Glu Ala 
     210                215                220
Val Pro Ser Pro Arg Pro Gln Gln Pro Ala Leu Thr Glu Arg Ser Leu 
 225                230                235                240
Gly Phe Leu Asp Val Thr Ile Met Tyr Lys Gly Arg Thr Val Leu Gln 
                 245                250                255
Ala Val Val Gly His Pro Arg Cys Val Phe Leu Tyr Ser Pro Met Ala 
             260                265                270
Pro Ala Val Arg Thr Ser Glu Pro Gln Pro Val Ile Phe Pro Ser Pro 
         275                280                285
Ala Glu Leu Pro Asp Gln Lys Gln Leu His Tyr Thr Glu Thr Leu Leu 
     290                295                300
Gln His Val Ser Pro Gly Leu Gln Leu Glu Leu Arg Gly Pro Ser Leu 
 305                310                315                320
Trp Ala Leu Arg Met Gly Lys Cys Lys Val Tyr Trp Glu Val Gly Ser 
                 325                330                335
Pro Met Gly Thr Thr Gly Pro Ser Thr Pro Pro Gln Leu Leu Glu Arg 
             340                345                350
Asn Arg His Thr Pro Ile Phe Asp Phe Ser Thr Phe Phe Arg Glu Leu 
         355                360                365
Glu Glu Phe Arg Ala Arg Arg Arg Gln Gly Ser Pro His Tyr Thr Ile 
     370                375                380
Tyr Leu Gly Phe Gly Gln Asp Leu Ser Ala Gly Arg Pro Lys Glu Lys 
 385                390                395                400
Thr Leu Ile Leu Val Lys Leu Glu Pro Trp Val Cys Lys Ala Tyr Leu 
                 405                410                415
Glu Gly Val Gln Arg Glu Gly Val Ser Ser Leu Asp Ser Ser Ser Leu 
             420                425                430
Gly Leu Cys Leu Ser Ser Thr Asn Ser Leu Tyr Glu Asp Ile Glu His 
         435                440                445
Phe Leu Met Asp Leu Gly Gln Trp Pro 
     450                455



<210> 4540
<211> 1864
<212> DNA
<213> Homo sapiens
<308> U73036
<400> 4540

tcggcacga  gggctctgg  acccagggt  cggcctgcg  cttcccgcc  ggcctggac  60
ctggttcaa  acctgtgac  tcatgtgtg  gcgccggcc  cacctgcag  cacacctgt  120
gccccctct  ccaagagat  cataccgag  cagcgtcgg  ggctacaag  cctcagtcc  180
cacctgtgg  cacctgtga  acctggcca  acgacctgt  gccgcggcc  ggcgtctgc  240
gcgacagga  cccttacct  ccctgttat  acacctgac  gccacctaa  tgcccctgc  300
gaaggagca  tggccttgg  tcctgagag  gcagcccca  gcgtgctgt  cggagagtg  360
ctccttgga  agatcagca  cggctgcta  gaggggctg  agtggctgg  cgaggcccg  420
acctgtttc  gcgtgccct  gaagcactt  gcgcgcaag  acctgagcg  ggccgacgc  480
cgcatcttc  aggcctggg  tgtggcccg  ggcaggtgg  cgcctagca  caggggagg  540
ggcccgccc  ccgaggctg  gactgcgga  cgcgccggc  ggaaaacca  cttccgctg  600
gcactgcgc  gcacgcgtc  cttcgtgat  ctgcgagat  actcggggg  cccggccga  660
ccgcacaag  tgtacgcgc  cagccggga  ctgtgctgg  gagaaggcc  aggcacgga  720
cagactgag  cagaggccc  cgcagctgt  ccaccacca  agggtgggc  cccagggcc  780
ttcctggca  acacacatg  tggactcca  gccccaggc  ccctccctg  cccagctgg  840
gacgagggg  acctcctgc  ccaggcagt  caacagagc  gcctggcag  ccatctgct  900
acagcgtca  ggggggcag  tccagtccc  accaaggct  ctggagagg  acaagaagg  960
cttcccctg  ctggggcct  tgctggagg  ccagggctc  ctgctgggg  gctgtacgg  1020
tgggcagta  agacgaccc  cagccccgg  ccccagccc  cggcactaa  gacaggcga  1080
gccgcggcc  cagagtccc  gcaccaggc  gagccgtac  tgtcaccct  cccaagcgc  1140
tgcaccgcg  tgcaagagc  cagcccagg  gcgctggac  tgaccatca  gtacaaggg  1200
cgcacggtg  tgcagaagg  ggtgggaca  ccgagctgc  cgttcctat  cggcccccc  1260
gacccagct  tccgggcca  agaccccca  caggtagca  tccccagcc  tgccgagct  1320
ccggaccag  agcagctgc  ctacacgga  gaactgctg  ggcacgtgg  ccctgggtt  1380
cacctggag  ttcgggggc  acagctgtg  gcccggcgc  tgggcaagt  caaggtgta  1440
tgggaggtg  gcggacccc  aggctccgc  agcccctcc  ccccagcct  cctgctgcc  1500
cggaactgt  acaccccca  cttcgactt  agagtcttc  tccaagagc  ggtggaatt  1560
cgggcacgg  agcgccgtg  ctccccacg  tataccatc  acctgggct  cgggcagga  1620
ctgtcagct  ggaggccca  ggagaagag  ctggtcctg  tgaagctgg  accctggct  1680
tgccgagtg  acctagagg  cacgcagcg  gagggtgtg  cttccctgg  tagcagcag  1740
ctcagcctc  gcctgtcca  cgccaacag  ctctatgac  acatcgagt  cttccttat  1800
gagctggag  agcccgcct  gaacccagt  taatgagaa  tccagaaag  tggagcagc  1860
cacc  1864



<210> 4541
<211> 503
<212> PRT
<213> Homo sapiens
<308> Q92985
<400> 4541

Met Ala Leu Ala Pro Glu Arg Ala Ala Pro Arg Val Leu Phe Gly Glu 
  1               5                  10                  15
Trp Leu Leu Gly Glu Ile Ser Ser Gly Cys Tyr Glu Gly Leu Gln Trp 
             20                  25                  30
Leu Asp Glu Ala Arg Thr Cys Phe Arg Val Pro Trp Lys His Phe Ala 
         35                  40                  45
Arg Lys Asp Leu Ser Glu Ala Asp Ala Arg Ile Phe Lys Ala Trp Ala 
     50                  55                  60
Val Ala Arg Gly Arg Trp Pro Pro Ser Ser Arg Gly Gly Gly Pro Pro 
 65                  70                  75                  80
Pro Glu Ala Glu Thr Ala Glu Arg Ala Gly Trp Lys Thr Asn Phe Arg 
                 85                  90                  95
Cys Ala Leu Arg Ser Thr Arg Arg Phe Val Met Leu Arg Asp Asn Ser 
             100                105                110
Gly Asp Pro Ala Asp Pro His Lys Val Tyr Ala Leu Ser Arg Glu Leu 
         115                120                125
Cys Trp Arg Glu Gly Pro Gly Thr Asp Gln Thr Glu Ala Glu Ala Pro 
     130                135                140
Ala Ala Val Pro Pro Pro Gln Gly Gly Pro Pro Gly Pro Phe Leu Ala 
 145                150                155                160
His Thr His Ala Gly Leu Gln Ala Pro Gly Pro Leu Pro Ala Pro Ala 
                 165                170                175
Gly Asp Glu Gly Asp Leu Leu Leu Gln Ala Val Gln Gln Ser Cys Leu 
             180                185                190
Ala Asp His Leu Leu Thr Ala Ser Trp Gly Ala Asp Pro Val Pro Thr 
         195                200                205
Lys Ala Pro Gly Glu Gly Gln Glu Gly Leu Pro Leu Thr Gly Ala Cys 
     210                215                220
Ala Gly Gly Pro Gly Leu Pro Ala Gly Glu Leu Tyr Gly Trp Ala Val 
 225                230                235                240
Glu Thr Thr Pro Ser Pro Gly Pro Gln Pro Ala Ala Leu Thr Thr Gly 
                 245                250                255
Glu Ala Ala Ala Pro Glu Ser Pro His Gln Ala Glu Pro Tyr Leu Ser 
             260                265                270
Pro Ser Pro Ser Ala Cys Thr Ala Val Gln Glu Pro Ser Pro Gly Ala 
         275                280                285
Leu Asp Val Thr Ile Met Tyr Lys Gly Arg Thr Val Leu Gln Lys Val 
     290                295                300
Val Gly His Pro Ser Cys Thr Phe Leu Tyr Gly Pro Pro Asp Pro Ala 
 305                310                315                320
Val Arg Ala Thr Asp Pro Gln Gln Val Ala Phe Pro Ser Pro Ala Glu 
                 325                330                335
Leu Pro Asp Gln Lys Gln Leu Arg Tyr Thr Glu Glu Leu Leu Arg His 
             340                345                350
Val Ala Pro Gly Leu His Leu Glu Leu Arg Gly Pro Gln Leu Trp Ala 
         355                360                365
Arg Arg Met Gly Lys Cys Lys Val Tyr Trp Glu Val Gly Gly Pro Pro 
     370                375                380
Gly Ser Ala Ser Pro Ser Thr Pro Ala Cys Leu Leu Pro Arg Asn Cys 
 385                390                395                400
Asp Thr Pro Ile Phe Asp Phe Arg Val Phe Phe Gln Glu Leu Val Glu 
                 405                410                415
Phe Arg Ala Arg Gln Arg Arg Gly Ser Pro Arg Tyr Thr Ile Tyr Leu 
             420                425                430
Gly Phe Gly Gln Asp Leu Ser Ala Gly Arg Pro Lys Glu Lys Ser Leu 
         435                440                445
Val Leu Val Lys Leu Glu Pro Trp Leu Cys Arg Val His Leu Glu Gly 
     450                455                460
Thr Gln Arg Glu Gly Val Ser Ser Leu Asp Ser Ser Ser Leu Ser Leu 
 465                470                475                480
Cys Leu Ser Ser Ala Asn Ser Leu Tyr Asp Asp Ile Glu Cys Phe Leu 
                 485                490                495
Met Glu Leu Glu Gln Pro Ala 
             500



<210> 4542
<211> 499
<212> DNA
<213> Rattus norvegicus
<308> AA799861
<400> 4542

ggtaaccca  ccaattctt  attgtaaag  tgagtgcta  aaaggaggc  tagtgtgta  60
ggagtgggg  gtcaccttc  ttcaaggga  tccacaagg  ccactagag  tgacatata  120
ccaaggaat  agcctgagc  agggcagca  tggttctga  ctctattgg  agttggggt  180
ctgaatcaa  cccactgac  caggtccat  aggaagtgt  caatgtcat  gtagagact  240
ttggtgcta  acaagcaca  gccaagact  ctgctgtcc  gagaggaca  accctcacg  300
tgcacgcct  ccagatgtg  cttgcacag  catggctcc  gcttcacca  gatcaggct  360
ttctccttg  gcctccctg  tgacaagtc  tgcccaaaa  ccaggtaga  ggtgtaatg  420
ggtgatcct  gtcgcctcc  ggcccggaa  tcctccagt  ctcggaaga  atgctgaag  480
caaagatgg  agtatggca  499



<210> 4543
<211> 457
<212> PRT
<213> Rattus norvegicus
<308> NP_058546
<400> 4543

Met Ala Glu Val Arg Gly Val Gln Arg Val Leu Phe Gly Asp Trp Leu 
  1               5                  10                  15
Leu Gly Glu Val Ser Ser Gly Gln Tyr Glu Gly Leu Gln Trp Leu Asn 
             20                  25                  30
Glu Ala Arg Thr Val Phe Arg Val Pro Trp Lys His Phe Gly Arg Arg 
         35                  40                  45
Asp Leu Asp Glu Glu Asp Ala Gln Ile Phe Lys Ala Trp Ala Val Ala 
     50                  55                  60
Arg Gly Arg Trp Pro Pro Ser Gly Val Asn Leu Pro Pro Pro Glu Ala 
 65                  70                  75                  80
Glu Ala Ala Glu Arg Arg Glu Arg Arg Gly Trp Lys Thr Asn Phe Arg 
                 85                  90                  95
Cys Ala Leu His Ser Thr Gly Arg Phe Ile Leu Arg Gln Asp Asn Ser 
             100                105                110
Gly Asp Pro Val Asp Pro His Lys Val Tyr Glu Leu Ser Arg Glu Leu 
         115                120                125
Gly Ser Thr Val Gly Pro Ala Thr Glu Asn Arg Glu Glu Val Ser Leu 
     130                135                140
Ser Asn Ala Leu Pro Thr Gln Gly Val Ser Pro Gly Ser Phe Leu Ala 
 145                150                155                160
Arg Glu Asn Ala Gly Leu Gln Thr Pro Ser Pro Leu Leu Ser Ser Asp 
                 165                170                175
Ala Gly Asp Leu Leu Leu Gln Val Leu Gln Tyr Ser His Ile Leu Glu 
             180                185                190
Ser Glu Ser Gly Ala Asp Pro Val Pro Pro Gln Ala Pro Gly Gln Glu 
         195                200                205
Gln Asp Arg Val Tyr Glu Glu Pro Tyr Ala Ala Trp Gln Val Glu Ala 
     210                215                220
Val Pro Ser Pro Arg Pro Gln Gln Pro Ala Leu Thr Glu Arg Ser Leu 
 225                230                235                240
Gly Phe Leu Asp Val Thr Ile Met Tyr Lys Gly Arg Thr Val Leu Gln 
                 245                250                255
Ala Val Val Gly His Pro Arg Cys Val Phe Leu Tyr Ser Pro Met Ala 
             260                265                270
Pro Ala Val Arg Thr Ser Glu Pro Gln Pro Val Ile Phe Pro Ser Pro 
         275                280                285
Ala Glu Leu Pro Asp Gln Lys Gln Leu His Tyr Thr Glu Thr Leu Leu 
     290                295                300
Gln His Val Ser Pro Gly Leu Gln Leu Glu Leu Arg Gly Pro Ser Leu 
 305                310                315                320
Trp Ala Leu Arg Met Gly Lys Cys Lys Val Tyr Trp Glu Val Gly Ser 
                 325                330                335
Pro Met Gly Thr Thr Gly Pro Ser Thr Pro Pro Gln Leu Leu Glu Arg 
             340                345                350
Asn Arg His Thr Pro Ile Phe Asp Phe Ser Thr Phe Phe Arg Glu Leu 
         355                360                365
Glu Glu Phe Arg Ala Arg Arg Arg Gln Gly Ser Pro His Tyr Thr Ile 
     370                375                380
Tyr Leu Gly Phe Gly Gln Asp Leu Ser Ala Gly Arg Pro Lys Glu Lys 
 385                390                395                400
Thr Leu Ile Leu Val Lys Leu Glu Pro Trp Val Cys Lys Ala Tyr Leu 
                 405                410                415
Glu Gly Val Gln Arg Glu Gly Val Ser Ser Leu Asp Ser Ser Ser Leu 
             420                425                430
Gly Leu Cys Leu Ser Ser Thr Asn Ser Leu Tyr Glu Asp Ile Glu His 
         435                440                445
Phe Leu Met Asp Leu Gly Gln Trp Pro 
     450                455



<210> 4544
<211> 1864
<212> DNA
<213> Homo sapiens
<308> U73036
<400> 4544

tcggcacga  gggctctgg  acccagggt  cggcctgcg  cttcccgcc  ggcctggac  60
ctggttcaa  acctgtgac  tcatgtgtg  gcgccggcc  cacctgcag  cacacctgt  120
gccccctct  ccaagagat  cataccgag  cagcgtcgg  ggctacaag  cctcagtcc  180
cacctgtgg  cacctgtga  acctggcca  acgacctgt  gccgcggcc  ggcgtctgc  240
gcgacagga  cccttacct  ccctgttat  acacctgac  gccacctaa  tgcccctgc  300
gaaggagca  tggccttgg  tcctgagag  gcagcccca  gcgtgctgt  cggagagtg  360
ctccttgga  agatcagca  cggctgcta  gaggggctg  agtggctgg  cgaggcccg  420
acctgtttc  gcgtgccct  gaagcactt  gcgcgcaag  acctgagcg  ggccgacgc  480
cgcatcttc  aggcctggg  tgtggcccg  ggcaggtgg  cgcctagca  caggggagg  540
ggcccgccc  ccgaggctg  gactgcgga  cgcgccggc  ggaaaacca  cttccgctg  600
gcactgcgc  gcacgcgtc  cttcgtgat  ctgcgagat  actcggggg  cccggccga  660
ccgcacaag  tgtacgcgc  cagccggga  ctgtgctgg  gagaaggcc  aggcacgga  720
cagactgag  cagaggccc  cgcagctgt  ccaccacca  agggtgggc  cccagggcc  780
ttcctggca  acacacatg  tggactcca  gccccaggc  ccctccctg  cccagctgg  840
gacgagggg  acctcctgc  ccaggcagt  caacagagc  gcctggcag  ccatctgct  900
acagcgtca  ggggggcag  tccagtccc  accaaggct  ctggagagg  acaagaagg  960
cttcccctg  ctggggcct  tgctggagg  ccagggctc  ctgctgggg  gctgtacgg  1020
tgggcagta  agacgaccc  cagccccgg  ccccagccc  cggcactaa  gacaggcga  1080
gccgcggcc  cagagtccc  gcaccaggc  gagccgtac  tgtcaccct  cccaagcgc  1140
tgcaccgcg  tgcaagagc  cagcccagg  gcgctggac  tgaccatca  gtacaaggg  1200
cgcacggtg  tgcagaagg  ggtgggaca  ccgagctgc  cgttcctat  cggcccccc  1260
gacccagct  tccgggcca  agaccccca  caggtagca  tccccagcc  tgccgagct  1320
ccggaccag  agcagctgc  ctacacgga  gaactgctg  ggcacgtgg  ccctgggtt  1380
cacctggag  ttcgggggc  acagctgtg  gcccggcgc  tgggcaagt  caaggtgta  1440
tgggaggtg  gcggacccc  aggctccgc  agcccctcc  ccccagcct  cctgctgcc  1500
cggaactgt  acaccccca  cttcgactt  agagtcttc  tccaagagc  ggtggaatt  1560
cgggcacgg  agcgccgtg  ctccccacg  tataccatc  acctgggct  cgggcagga  1620
ctgtcagct  ggaggccca  ggagaagag  ctggtcctg  tgaagctgg  accctggct  1680
tgccgagtg  acctagagg  cacgcagcg  gagggtgtg  cttccctgg  tagcagcag  1740
ctcagcctc  gcctgtcca  cgccaacag  ctctatgac  acatcgagt  cttccttat  1800
gagctggag  agcccgcct  gaacccagt  taatgagaa  tccagaaag  tggagcagc  1860
cacc  1864



<210> 4545
<211> 503
<212> PRT
<213> Homo sapiens
<308> Q92985
<400> 4545

Met Ala Leu Ala Pro Glu Arg Ala Ala Pro Arg Val Leu Phe Gly Glu 
  1               5                  10                  15
Trp Leu Leu Gly Glu Ile Ser Ser Gly Cys Tyr Glu Gly Leu Gln Trp 
             20                  25                  30
Leu Asp Glu Ala Arg Thr Cys Phe Arg Val Pro Trp Lys His Phe Ala 
         35                  40                  45
Arg Lys Asp Leu Ser Glu Ala Asp Ala Arg Ile Phe Lys Ala Trp Ala 
     50                  55                  60
Val Ala Arg Gly Arg Trp Pro Pro Ser Ser Arg Gly Gly Gly Pro Pro 
 65                  70                  75                  80
Pro Glu Ala Glu Thr Ala Glu Arg Ala Gly Trp Lys Thr Asn Phe Arg 
                 85                  90                  95
Cys Ala Leu Arg Ser Thr Arg Arg Phe Val Met Leu Arg Asp Asn Ser 
             100                105                110
Gly Asp Pro Ala Asp Pro His Lys Val Tyr Ala Leu Ser Arg Glu Leu 
         115                120                125
Cys Trp Arg Glu Gly Pro Gly Thr Asp Gln Thr Glu Ala Glu Ala Pro 
     130                135                140
Ala Ala Val Pro Pro Pro Gln Gly Gly Pro Pro Gly Pro Phe Leu Ala 
 145                150                155                160
His Thr His Ala Gly Leu Gln Ala Pro Gly Pro Leu Pro Ala Pro Ala 
                 165                170                175
Gly Asp Glu Gly Asp Leu Leu Leu Gln Ala Val Gln Gln Ser Cys Leu 
             180                185                190
Ala Asp His Leu Leu Thr Ala Ser Trp Gly Ala Asp Pro Val Pro Thr 
         195                200                205
Lys Ala Pro Gly Glu Gly Gln Glu Gly Leu Pro Leu Thr Gly Ala Cys 
     210                215                220
Ala Gly Gly Pro Gly Leu Pro Ala Gly Glu Leu Tyr Gly Trp Ala Val 
 225                230                235                240
Glu Thr Thr Pro Ser Pro Gly Pro Gln Pro Ala Ala Leu Thr Thr Gly 
                 245                250                255
Glu Ala Ala Ala Pro Glu Ser Pro His Gln Ala Glu Pro Tyr Leu Ser 
             260                265                270
Pro Ser Pro Ser Ala Cys Thr Ala Val Gln Glu Pro Ser Pro Gly Ala 
         275                280                285
Leu Asp Val Thr Ile Met Tyr Lys Gly Arg Thr Val Leu Gln Lys Val 
     290                295                300
Val Gly His Pro Ser Cys Thr Phe Leu Tyr Gly Pro Pro Asp Pro Ala 
 305                310                315                320
Val Arg Ala Thr Asp Pro Gln Gln Val Ala Phe Pro Ser Pro Ala Glu 
                 325                330                335
Leu Pro Asp Gln Lys Gln Leu Arg Tyr Thr Glu Glu Leu Leu Arg His 
             340                345                350
Val Ala Pro Gly Leu His Leu Glu Leu Arg Gly Pro Gln Leu Trp Ala 
         355                360                365
Arg Arg Met Gly Lys Cys Lys Val Tyr Trp Glu Val Gly Gly Pro Pro 
     370                375                380
Gly Ser Ala Ser Pro Ser Thr Pro Ala Cys Leu Leu Pro Arg Asn Cys 
 385                390                395                400
Asp Thr Pro Ile Phe Asp Phe Arg Val Phe Phe Gln Glu Leu Val Glu 
                 405                410                415
Phe Arg Ala Arg Gln Arg Arg Gly Ser Pro Arg Tyr Thr Ile Tyr Leu 
             420                425                430
Gly Phe Gly Gln Asp Leu Ser Ala Gly Arg Pro Lys Glu Lys Ser Leu 
         435                440                445
Val Leu Val Lys Leu Glu Pro Trp Leu Cys Arg Val His Leu Glu Gly 
     450                455                460
Thr Gln Arg Glu Gly Val Ser Ser Leu Asp Ser Ser Ser Leu Ser Leu 
 465                470                475                480
Cys Leu Ser Ser Ala Asn Ser Leu Tyr Asp Asp Ile Glu Cys Phe Leu 
                 485                490                495
Met Glu Leu Glu Gln Pro Ala 
             500



<210> 4546
<211> 510
<212> DNA
<213> Rattus norvegicus
<308> AA799889
<400> 4546

acaagagcc  tttcaagtt  tagagaaat  taatagaag  atatacaaa  tagacactg  60
tagtatgta  aaaagtatt  tctacattt  tgaacaata  caactatgc  acttgcagt  120
aacaggatg  tacaaaatc  tccaataaa  cattttcta  taagcacat  acacaacat  180
attcaattt  attaaaaaa  taacttcaa  atacagaat  atcctggtt  ggaagaaaa  240
ccatttctg  agttcactt  ggtataaac  gcaaggctg  cactactga  tatgagcgc  300
tgtctggta  aggttaaac  ctgtccaca  tggcagtag  tggtaggtg  atgcccttc  360
tctccctat  ctaatcccc  gaacctgcc  atgtctcta  ctcctctgg  gccatggga  420
tgcaagtag  gatttatct  tggggtttg  tatagttac  ttgaccctt  aagcaggag  480
aaggcanag  ttttgaaga  agacgaagat  510



<210> 4547
<211> 1482
<212> PRT
<213> Rattus norvegicus
<308> NP_035048
<400> 4547

Met Val Thr Leu Gly Ser Gly Gly Ala Gly Arg Ala Phe Ser Gly Ala 
  1               5                  10                  15
Val Arg Pro Ala Arg Arg Arg Pro Ala Ala Ala Leu Ala Met Gly Ala 
             20                  25                  30
Gln Asp Arg Pro Gln Cys His Phe Asp Ile Glu Ile Asn Arg Glu Pro 
         35                  40                  45
Val Gly Arg Ile Met Phe Gln Leu Phe Ser Asp Ile Cys Pro Lys Thr 
     50                  55                  60
Cys Lys Asn Phe Leu Cys Leu Cys Ser Gly Glu Lys Gly Leu Gly Lys 
 65                  70                  75                  80
Thr Thr Gly Lys Lys Leu Cys Tyr Lys Gly Ser Thr Phe His Arg Val 
                 85                  90                  95
Val Lys Asn Phe Met Ile Gln Gly Gly Asp Phe Ser Glu Gly Asn Gly 
             100                105                110
Lys Gly Gly Glu Ser Ile Tyr Gly Gly Tyr Phe Lys Asp Glu Asn Phe 
         115                120                125
Ile Leu Lys His Asp Arg Ala Phe Leu Leu Ser Met Ala Asn Arg Gly 
     130                135                140
Lys His Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Lys Pro Ala Pro 
 145                150                155                160
His Leu Asp Gly Val His Val Val Phe Gly Leu Val Ile Ser Gly Phe 
                 165                170                175
Glu Val Ile Glu Gln Ile Glu Asn Leu Lys Thr Asp Ala Ala Ser Arg 
             180                185                190
Pro Tyr Ala Asp Val Arg Val Ile Asp Cys Gly Val Leu Ala Thr Lys 
         195                200                205
Leu Thr Lys Asp Val Phe Glu Lys Lys Arg Lys Lys Pro Thr Cys Ser 
     210                215                220
Glu Gly Ser Asp Ser Ser Ser Arg Ser Ser Ser Ser Ser Glu Ser Ser 
 225                230                235                240
Ser Glu Ser Glu Val Glu Arg Glu Thr Ile Arg Arg Arg Arg His Lys 
                 245                250                255
Arg Arg Pro Lys Val Arg His Ala Lys Lys Arg Arg Lys Glu Met Ser 
             260                265                270
Ser Ser Glu Glu Pro Arg Arg Lys Arg Thr Val Ser Pro Glu Gly Tyr 
         275                280                285
Ser Glu Arg Ser Asp Val Asn Glu Lys Arg Ser Val Asp Ser Asn Thr 
     290                295                300
Lys Arg Glu Lys Pro Val Val Arg Pro Glu Glu Ile Pro Pro Val Pro 
 305                310                315                320
Glu Asn Arg Phe Leu Leu Arg Arg Asp Met Pro Ala Ile Thr Val Glu 
                 325                330                335
Pro Glu Gln Asn Ile Pro Asp Val Ala Pro Val Val Ser Asp Gln Lys 
             340                345                350
Pro Ser Val Ser Lys Ser Gly Arg Lys Ile Lys Gly Arg Gly Thr Ile 
         355                360                365
Arg Tyr His Thr Pro Pro Arg Ser Arg Ser His Ser Glu Ser Lys Asp 
     370                375                380
Asp Asp Ser Ser Glu Thr Pro Pro His Trp Lys Glu Glu Met Gln Arg 
 385                390                395                400
Leu Arg Ala Tyr Arg Pro Pro Ser Gly Glu Lys Trp Ser Lys Gly Asp 
                 405                410                415
Lys Leu Ser Asp Pro Cys Ser Ser Arg Trp Asp Glu Arg Ser Leu Ser 
             420                425                430
Gln Arg Ser Arg Ser Trp Ser Tyr Asn Gly Tyr Tyr Ser Asp Leu Ser 
         435                440                445
Thr Ala Arg His Ser Asp Gly His His Lys Lys His Arg Lys Glu Lys 
     450                455                460
Lys Phe Lys His Lys Lys Lys Ala Lys Lys Gln Lys His Cys Arg Arg 
 465                470                475                480
His Arg Gln Thr Lys Lys Arg Arg Ile Val Met Pro Asp Leu Glu Pro 
                 485                490                495
Ser Arg Ser Pro Thr His Arg Met Lys Ser Ser Cys Val Arg Glu Arg 
             500                505                510
Arg Ser Arg Ala Ser Ser Ser Ser Ser His His Ser Ser Lys Arg Asp 
         515                520                525
Trp Ser Lys Ser Asp Gln Asp Asp Gly Ser Ala Ser Thr His Ser Ser 
     530                535                540
Arg Asp Ser Tyr Arg Ser Lys Ser His Ser Arg Ser Asp Ser Arg Gly 
 545                550                555                560
Ser Ser Arg Ser Arg Ala Val Ser Lys Ser Ser Ser Arg Ser Leu Asn 
                 565                570                575
Arg Ser Lys Ser Arg Ser Ser Ser Arg Ser Gly Pro Arg Arg Thr Ser 
             580                585                590
Ile Ser Pro Lys Lys Pro Ala Gln Leu Ser Glu Asn Lys Pro Val Lys 
         595                600                605
Thr Glu Pro Leu Arg Pro Ser Val Pro Gln Asn Gly Asn Val Leu Val 
     610                615                620
Gln Pro Val Ala Ala Glu Asn Ile Pro Val Ile Pro Leu Ser Asp Ser 
 625                630                635                640
Pro Pro Pro Ser Arg Trp Lys Pro Gly Gln Lys Pro Trp Lys Pro Ser 
                 645                650                655
Tyr Glu Arg Ile Gln Glu Met Lys Ala Lys Thr Thr His Leu Leu Pro 
             660                665                670
Val Gln Ser Thr Tyr Ser Leu Thr Asn Ile Lys Ala Thr Val Ser Ser 
         675                680                685
Ser Ser Tyr His Lys Arg Glu Lys Pro Ser Glu Ser Asp Gly Ser Ala 
     690                695                700
Tyr Ser Lys Tyr Ser Asp Arg Ser Ser Gly Ser Ser Gly Arg Ser Gly 
 705                710                715                720
Ser Lys Ser Ser Arg Ser Arg Ser Ser Ser Arg Ser Tyr Thr Arg Ser 
                 725                730                735
Arg Ser Arg Ser Leu Pro Thr Ser Arg Ser Leu Ser Arg Ser Pro Ser 
             740                745                750
Ser Arg Ser His Ser Pro Asn Lys Tyr Ser Asp Gly Ser Gln His Ser 
         755                760                765
Arg Ser Ser Ser Tyr Thr Ser Val Ser Ser Asp Asp Gly Arg Arg Ala 
     770                775                780
Met Phe Arg Ser Asn Arg Lys Lys Ser Val Thr Ser His Lys Arg His 
 785                790                795                800
Arg Ser Asn Ser Glu Lys Thr Leu His Ser Lys Tyr Val Arg Gly Arg 
                 805                810                815
Glu Lys Ser Ser Arg His Arg Lys Tyr Ser Glu Ser Arg Ser Ser Leu 
             820                825                830
Asp Tyr Thr Ser Asp Ser Asp Gln Ser His Val Gln Val Tyr Ser Ala 
         835                840                845
Pro Glu Lys Glu Lys Gln Gly Lys Val Glu Ala Leu Asn Asp Lys Gln 
     850                855                860
Gly Lys Gly Arg Glu Glu Gly Lys Pro Lys Pro Glu Trp Glu Cys Pro 
 865                870                875                880
Arg Ser Lys Lys Glu Asn Ser Glu Asp His Ser Arg Asp Asp Ser Val 
                 885                890                895
Ser Lys Gly Lys Asn Cys Ala Gly Ser Lys Trp Asp Ser Glu Ser Asn 
             900                905                910
Ser Glu Gln Asp Val Thr Lys Ser Arg Lys Ser Asp Pro Arg Arg Gly 
         915                920                925
Ser Glu Lys Glu Glu Gly Glu Ala Ser Ser Asp Ser Glu Ser Glu Val 
     930                935                940
Gly Gln Ser His Ile Lys Ala Lys Pro Pro Ala Lys Pro Pro Thr Ser 
 945                950                955                960
Thr Phe Leu Pro Gly Ser Asp Gly Ala Trp Lys Ser Arg Arg Pro Gln 
                 965                970                975
Ser Ser Ala Ser Glu Ser Glu Ser Ser Cys Ser Asn Leu Gly Asn Ile 
             980                985                990
Arg Gly Glu Pro Gln Lys Gln Lys His Ser Lys Asp Asp Leu Lys Gly 
         995                1000                1005
Asp His Thr Lys Arg Ala Arg Glu Lys Ser Lys Ala Lys Lys Asp Lys 
     1010                1015                1020
Lys His Lys Ala Pro Lys Arg Lys Gln Ala Phe His Trp Gln Pro Pro 
 1025                1030                1035                1040
Leu Glu Phe Gly Asp Asp Glu Glu Glu Glu Met Asn Gly Lys Gln Val 
                 1045                1050                1055
Thr Gln Asp Pro Lys Glu Lys Arg His Val Ser Glu Lys Cys Glu Ala 
             1060                1065                1070
Val Lys Asp Gly Ile Pro Asn Val Glu Lys Thr Cys Asp Glu Gly Ser 
         1075                1080                1085
Ser Pro Ser Lys Pro Lys Lys Gly Thr Leu Glu Gln Asp Pro Leu Ala 
     1090                1095                1100
Glu Gly Gly His Asp Pro Ser Ser Cys Pro Ala Pro Leu Lys Val Glu 
 1105                1110                1115                1120
Asp Asn Thr Ala Ser Ser Pro Pro Ser Ala Gln His Leu Glu Glu His 
                 1125                1130                1135
Gly Pro Gly Gly Gly Glu Asp Val Leu Gln Thr Asp Asp Asn Met Glu 
             1140                1145                1150
Ile Cys Thr Pro Asp Arg Thr Ser Pro Ala Lys Gly Glu Val Val Ser 
         1155                1160                1165
Pro Leu Ala Asn His Arg Leu Asp Ser Pro Glu Val Asn Ile Ile Pro 
     1170                1175                1180
Glu Gln Asp Glu Cys Met Ala His Pro Arg Ala Gly Gly Glu Gln Glu 
 1185                1190                1195                1200
Ser Ser Met Ser Glu Ser Lys Thr Leu Gly Glu Ser Gly Val Lys Gln 
                 1205                1210                1215
Asp Ser Ser Thr Ser Val Thr Ser Pro Val Glu Thr Ser Gly Lys Lys 
             1220                1225                1230
Glu Gly Ala Glu Lys Ser Gln Met Asn Leu Thr Asp Lys Trp Lys Pro 
         1235                1240                1245
Leu Gln Gly Val Gly Asn Leu Ser Val Ser Thr Ala Thr Thr Ser Ser 
     1250                1255                1260
Ala Leu Asp Val Lys Ala Leu Ser Thr Val Pro Glu Val Lys Pro Gln 
 1265                1270                1275                1280
Gly Leu Arg Ile Glu Ile Lys Ser Lys Asn Lys Val Arg Pro Gly Ser 
                 1285                1290                1295
Leu Phe Asp Glu Val Arg Lys Thr Ala Arg Leu Asn Arg Arg Pro Arg 
             1300                1305                1310
Asn Gln Glu Ser Ser Ser Asp Asp Gln Thr Pro Ser Arg Asp Gly Asp 
         1315                1320                1325
Ser Gln Ser Arg Ser Pro His Arg Ser Arg Ser Lys Ser Glu Thr Lys 
     1330                1335                1340
Ser Arg His Arg Thr Arg Ser Val Ser Tyr Ser His Ser Arg Ser Arg 
 1345                1350                1355                1360
Ser Arg Ser Ser Thr Ser Ser Tyr Arg Ser Arg Ser Tyr Ser Arg Ser 
                 1365                1370                1375
Arg Ser Arg Asp Trp Tyr Ser Arg Gly Arg Thr Arg Ser Arg Ser Ser 
             1380                1385                1390
Ser Tyr Gly Ser Phe His Ser His Arg Thr Ser Ser Arg Ser Arg Ser 
         1395                1400                1405
Arg Ser Ser Ser Tyr Asp Leu His Ser Arg Ser Arg Ser Tyr Thr Tyr 
     1410                1415                1420
Asp Ser Tyr Tyr Ser Arg Ser Arg Ser Arg Ser Arg Ser Gln Arg Ser 
 1425                1430                1435                1440
Asp Ser Tyr His Arg Gly Arg Ser Tyr Asn Arg Arg Ser Arg Ser Gly 
                 1445                1450                1455
Arg Ser Tyr Gly Ser Asp Ser Glu Ser Asp Arg Ser Tyr Ser His His 
             1460                1465                1470
Arg Ser Pro Ser Glu Ser Ser Arg Tyr Ser 
         1475                1480



<210> 4548
<211> 550
<212> DNA
<213> Homo sapiens
<308> AI628792
<400> 4548

ttttttatt  tttttttta  actaaggat  tattttaat  tctacaagg  cccctttca  60
gttttaggg  aatttaact  aagtgtata  aaattagac  ttgctaata  gtacaaaag  120
attttatac  gtttttgaa  gatactagc  atttgcaat  aacaggatg  tacaaaaac  180
gtccaataa  gcatttcct  ttaagaagc  caatacaca  cataattca  ttttattaa  240
aaaataact  caaaatgta  aacaatccc  tttaggaag  aaagctatt  ctgtagttc  300
ctctgtcag  aaacacaca  gttgaacgc  gcagcagag  gctgtcttt  tccatggag  360
aaagaaatg  ggcttctag  gcctatctt  tctgggtaa  aattccacc  acagctgag  420
tgggcagtt  ttgcctgtg  taggcagaa  ttgaaaatg  ccctccccc  ttcaatgag  480
taatctcca  aacccgtga  tatgatgag  tgagacagt  ctcctgcaa  tatgttcta  540
cgcacaatca  550



<210> 4549
<211> 656
<212> PRT
<213> Homo sapiens
<308> A47328
<400> 4549

Met Val Asn Glu Ala Arg Gly Asn Ser Ser Leu Asn Pro Cys Leu Glu 
  1               5                  10                  15
Gly Ser Ala Ser Ser Gly Ser Glu Ser Ser Lys Asp Ser Ser Arg Cys 
             20                  25                  30
Ser Thr Pro Gly Leu Asp Pro Glu Arg His Glu Arg Leu Arg Glu Lys 
         35                  40                  45
Met Arg Arg Arg Leu Glu Ser Gly Asp Lys Trp Phe Ser Leu Glu Phe 
     50                  55                  60
Phe Pro Pro Arg Thr Ala Glu Gly Ala Val Asn Leu Ile Ser Arg Phe 
 65                  70                  75                  80
Asp Arg Met Ala Ala Gly Gly Pro Leu Tyr Ile Asp Val Thr Trp His 
                 85                  90                  95
Pro Ala Gly Asp Pro Gly Ser Asp Lys Glu Thr Ser Ser Met Met Ile 
             100                105                110
Ala Ser Thr Ala Val Asn Tyr Cys Gly Leu Glu Thr Ile Leu His Met 
         115                120                125
Thr Cys Cys Arg Gln Arg Leu Glu Glu Ile Thr Gly His Leu His Lys 
     130                135                140
Ala Lys Gln Leu Gly Leu Lys Asn Ile Met Ala Leu Arg Gly Asp Pro 
 145                150                155                160
Ile Gly Asp Gln Trp Glu Glu Glu Glu Gly Gly Phe Asn Tyr Ala Val 
                 165                170                175
Asp Leu Val Lys His Ile Arg Ser Glu Phe Gly Asp Tyr Phe Asp Ile 
             180                185                190
Cys Val Ala Gly Tyr Pro Lys Gly His Pro Glu Ala Gly Ser Phe Glu 
         195                200                205
Ala Asp Leu Lys His Leu Lys Glu Lys Val Ser Ala Gly Ala Asp Phe 
     210                215                220
Ile Ile Thr Gln Leu Phe Phe Glu Ala Asp Thr Phe Phe Arg Phe Val 
 225                230                235                240
Lys Ala Cys Thr Asp Met Gly Ile Thr Cys Pro Ile Val Pro Gly Ile 
                 245                250                255
Phe Pro Ile Gln Gly Tyr His Ser Leu Arg Gln Leu Val Lys Leu Ser 
             260                265                270
Lys Leu Glu Val Pro Gln Glu Ile Lys Asp Val Ile Glu Pro Ile Lys 
         275                280                285
Asp Asn Asp Ala Ala Ile Arg Asn Tyr Gly Ile Glu Leu Ala Val Ser 
     290                295                300
Leu Cys Gln Glu Leu Leu Ala Ser Gly Leu Val Pro Gly Leu His Phe 
 305                310                315                320
Tyr Thr Leu Asn Arg Glu Met Ala Thr Thr Glu Val Leu Lys Arg Leu 
                 325                330                335
Gly Met Trp Thr Glu Asp Pro Arg Arg Pro Leu Pro Trp Ala Leu Ser 
             340                345                350
Ala His Pro Lys Arg Arg Glu Glu Asp Val Arg Pro Ile Phe Trp Ala 
         355                360                365
Ser Arg Pro Lys Ser Tyr Ile Tyr Arg Thr Gln Glu Trp Asp Glu Phe 
     370                375                380
Pro Asn Gly Arg Trp Gly Asn Ser Ser Ser Pro Ala Phe Gly Glu Leu 
 385                390                395                400
Lys Asp Tyr Tyr Leu Phe Tyr Leu Lys Ser Lys Ser Pro Lys Glu Glu 
                 405                410                415
Leu Leu Lys Met Trp Gly Glu Glu Leu Thr Ser Glu Ala Ser Val Phe 
             420                425                430
Glu Val Phe Val Leu Tyr Leu Ser Gly Glu Pro Asn Arg Asn Gly His 
         435                440                445
Lys Val Thr Cys Leu Pro Trp Asn Asp Glu Pro Leu Ala Ala Glu Thr 
     450                455                460
Ser Leu Leu Lys Glu Glu Leu Leu Arg Val Asn Arg Gln Gly Ile Leu 
 465                470                475                480
Thr Ile Asn Ser Gln Pro Asn Ile Asn Gly Lys Pro Ser Ser Asp Pro 
                 485                490                495
Ile Val Gly Trp Gly Pro Ser Gly Gly Tyr Val Phe Gln Lys Ala Tyr 
             500                505                510
Leu Glu Phe Phe Thr Ser Arg Glu Thr Ala Glu Ala Leu Leu Gln Val 
         515                520                525
Leu Lys Lys Tyr Glu Leu Arg Val Asn Tyr His Leu Val Asn Val Lys 
     530                535                540
Gly Glu Asn Ile Thr Asn Ala Pro Glu Leu Gln Pro Asn Ala Val Thr 
 545                550                555                560
Trp Gly Ile Phe Pro Gly Arg Glu Ile Ile Gln Pro Thr Val Val Asp 
                 565                570                575
Pro Val Ser Phe Met Phe Trp Lys Asp Glu Ala Phe Ala Leu Trp Ile 
             580                585                590
Glu Arg Trp Gly Lys Leu Tyr Glu Glu Glu Ser Pro Ser Arg Thr Ile 
         595                600                605
Ile Gln Tyr Ile His Asp Asn Tyr Phe Leu Val Asn Leu Val Asp Asn 
     610                615                620
Asp Phe Pro Leu Asp Asn Cys Leu Trp Gln Val Val Glu Asp Thr Leu 
 625                630                635                640
Glu Leu Leu Asn Arg Pro Thr Gln Asn Ala Arg Glu Thr Glu Ala Pro 
                 645                650                655



<210> 4550
<211> 510
<212> DNA
<213> Rattus norvegicus
<308> AA799889
<400> 4550

acaagagcc  tttcaagtt  tagagaaat  taatagaag  atatacaaa  tagacactg  60
tagtatgta  aaaagtatt  tctacattt  tgaacaata  caactatgc  acttgcagt  120
aacaggatg  tacaaaatc  tccaataaa  cattttcta  taagcacat  acacaacat  180
attcaattt  attaaaaaa  taacttcaa  atacagaat  atcctggtt  ggaagaaaa  240
ccatttctg  agttcactt  ggtataaac  gcaaggctg  cactactga  tatgagcgc  300
tgtctggta  aggttaaac  ctgtccaca  tggcagtag  tggtaggtg  atgcccttc  360
tctccctat  ctaatcccc  gaacctgcc  atgtctcta  ctcctctgg  gccatggga  420
tgcaagtag  gatttatct  tggggtttg  tatagttac  ttgaccctt  aagcaggag  480
aaggcanag  ttttgaaga  agacgaagat  510



<210> 4551
<211> 1482
<212> PRT
<213> Rattus norvegicus
<308> NP_035048
<400> 4551

Met Val Thr Leu Gly Ser Gly Gly Ala Gly Arg Ala Phe Ser Gly Ala 
  1               5                  10                  15
Val Arg Pro Ala Arg Arg Arg Pro Ala Ala Ala Leu Ala Met Gly Ala 
             20                  25                  30
Gln Asp Arg Pro Gln Cys His Phe Asp Ile Glu Ile Asn Arg Glu Pro 
         35                  40                  45
Val Gly Arg Ile Met Phe Gln Leu Phe Ser Asp Ile Cys Pro Lys Thr 
     50                  55                  60
Cys Lys Asn Phe Leu Cys Leu Cys Ser Gly Glu Lys Gly Leu Gly Lys 
 65                  70                  75                  80
Thr Thr Gly Lys Lys Leu Cys Tyr Lys Gly Ser Thr Phe His Arg Val 
                 85                  90                  95
Val Lys Asn Phe Met Ile Gln Gly Gly Asp Phe Ser Glu Gly Asn Gly 
             100                105                110
Lys Gly Gly Glu Ser Ile Tyr Gly Gly Tyr Phe Lys Asp Glu Asn Phe 
         115                120                125
Ile Leu Lys His Asp Arg Ala Phe Leu Leu Ser Met Ala Asn Arg Gly 
     130                135                140
Lys His Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Lys Pro Ala Pro 
 145                150                155                160
His Leu Asp Gly Val His Val Val Phe Gly Leu Val Ile Ser Gly Phe 
                 165                170                175
Glu Val Ile Glu Gln Ile Glu Asn Leu Lys Thr Asp Ala Ala Ser Arg 
             180                185                190
Pro Tyr Ala Asp Val Arg Val Ile Asp Cys Gly Val Leu Ala Thr Lys 
         195                200                205
Leu Thr Lys Asp Val Phe Glu Lys Lys Arg Lys Lys Pro Thr Cys Ser 
     210                215                220
Glu Gly Ser Asp Ser Ser Ser Arg Ser Ser Ser Ser Ser Glu Ser Ser 
 225                230                235                240
Ser Glu Ser Glu Val Glu Arg Glu Thr Ile Arg Arg Arg Arg His Lys 
                 245                250                255
Arg Arg Pro Lys Val Arg His Ala Lys Lys Arg Arg Lys Glu Met Ser 
             260                265                270
Ser Ser Glu Glu Pro Arg Arg Lys Arg Thr Val Ser Pro Glu Gly Tyr 
         275                280                285
Ser Glu Arg Ser Asp Val Asn Glu Lys Arg Ser Val Asp Ser Asn Thr 
     290                295                300
Lys Arg Glu Lys Pro Val Val Arg Pro Glu Glu Ile Pro Pro Val Pro 
 305                310                315                320
Glu Asn Arg Phe Leu Leu Arg Arg Asp Met Pro Ala Ile Thr Val Glu 
                 325                330                335
Pro Glu Gln Asn Ile Pro Asp Val Ala Pro Val Val Ser Asp Gln Lys 
             340                345                350
Pro Ser Val Ser Lys Ser Gly Arg Lys Ile Lys Gly Arg Gly Thr Ile 
         355                360                365
Arg Tyr His Thr Pro Pro Arg Ser Arg Ser His Ser Glu Ser Lys Asp 
     370                375                380
Asp Asp Ser Ser Glu Thr Pro Pro His Trp Lys Glu Glu Met Gln Arg 
 385                390                395                400
Leu Arg Ala Tyr Arg Pro Pro Ser Gly Glu Lys Trp Ser Lys Gly Asp 
                 405                410                415
Lys Leu Ser Asp Pro Cys Ser Ser Arg Trp Asp Glu Arg Ser Leu Ser 
             420                425                430
Gln Arg Ser Arg Ser Trp Ser Tyr Asn Gly Tyr Tyr Ser Asp Leu Ser 
         435                440                445
Thr Ala Arg His Ser Asp Gly His His Lys Lys His Arg Lys Glu Lys 
     450                455                460
Lys Phe Lys His Lys Lys Lys Ala Lys Lys Gln Lys His Cys Arg Arg 
 465                470                475                480
His Arg Gln Thr Lys Lys Arg Arg Ile Val Met Pro Asp Leu Glu Pro 
                 485                490                495
Ser Arg Ser Pro Thr His Arg Met Lys Ser Ser Cys Val Arg Glu Arg 
             500                505                510
Arg Ser Arg Ala Ser Ser Ser Ser Ser His His Ser Ser Lys Arg Asp 
         515                520                525
Trp Ser Lys Ser Asp Gln Asp Asp Gly Ser Ala Ser Thr His Ser Ser 
     530                535                540
Arg Asp Ser Tyr Arg Ser Lys Ser His Ser Arg Ser Asp Ser Arg Gly 
 545                550                555                560
Ser Ser Arg Ser Arg Ala Val Ser Lys Ser Ser Ser Arg Ser Leu Asn 
                 565                570                575
Arg Ser Lys Ser Arg Ser Ser Ser Arg Ser Gly Pro Arg Arg Thr Ser 
             580                585                590
Ile Ser Pro Lys Lys Pro Ala Gln Leu Ser Glu Asn Lys Pro Val Lys 
         595                600                605
Thr Glu Pro Leu Arg Pro Ser Val Pro Gln Asn Gly Asn Val Leu Val 
     610                615                620
Gln Pro Val Ala Ala Glu Asn Ile Pro Val Ile Pro Leu Ser Asp Ser 
 625                630                635                640
Pro Pro Pro Ser Arg Trp Lys Pro Gly Gln Lys Pro Trp Lys Pro Ser 
                 645                650                655
Tyr Glu Arg Ile Gln Glu Met Lys Ala Lys Thr Thr His Leu Leu Pro 
             660                665                670
Val Gln Ser Thr Tyr Ser Leu Thr Asn Ile Lys Ala Thr Val Ser Ser 
         675                680                685
Ser Ser Tyr His Lys Arg Glu Lys Pro Ser Glu Ser Asp Gly Ser Ala 
     690                695                700
Tyr Ser Lys Tyr Ser Asp Arg Ser Ser Gly Ser Ser Gly Arg Ser Gly 
 705                710                715                720
Ser Lys Ser Ser Arg Ser Arg Ser Ser Ser Arg Ser Tyr Thr Arg Ser 
                 725                730                735
Arg Ser Arg Ser Leu Pro Thr Ser Arg Ser Leu Ser Arg Ser Pro Ser 
             740                745                750
Ser Arg Ser His Ser Pro Asn Lys Tyr Ser Asp Gly Ser Gln His Ser 
         755                760                765
Arg Ser Ser Ser Tyr Thr Ser Val Ser Ser Asp Asp Gly Arg Arg Ala 
     770                775                780
Met Phe Arg Ser Asn Arg Lys Lys Ser Val Thr Ser His Lys Arg His 
 785                790                795                800
Arg Ser Asn Ser Glu Lys Thr Leu His Ser Lys Tyr Val Arg Gly Arg 
                 805                810                815
Glu Lys Ser Ser Arg His Arg Lys Tyr Ser Glu Ser Arg Ser Ser Leu 
             820                825                830
Asp Tyr Thr Ser Asp Ser Asp Gln Ser His Val Gln Val Tyr Ser Ala 
         835                840                845
Pro Glu Lys Glu Lys Gln Gly Lys Val Glu Ala Leu Asn Asp Lys Gln 
     850                855                860
Gly Lys Gly Arg Glu Glu Gly Lys Pro Lys Pro Glu Trp Glu Cys Pro 
 865                870                875                880
Arg Ser Lys Lys Glu Asn Ser Glu Asp His Ser Arg Asp Asp Ser Val 
                 885                890                895
Ser Lys Gly Lys Asn Cys Ala Gly Ser Lys Trp Asp Ser Glu Ser Asn 
             900                905                910
Ser Glu Gln Asp Val Thr Lys Ser Arg Lys Ser Asp Pro Arg Arg Gly 
         915                920                925
Ser Glu Lys Glu Glu Gly Glu Ala Ser Ser Asp Ser Glu Ser Glu Val 
     930                935                940
Gly Gln Ser His Ile Lys Ala Lys Pro Pro Ala Lys Pro Pro Thr Ser 
 945                950                955                960
Thr Phe Leu Pro Gly Ser Asp Gly Ala Trp Lys Ser Arg Arg Pro Gln 
                 965                970                975
Ser Ser Ala Ser Glu Ser Glu Ser Ser Cys Ser Asn Leu Gly Asn Ile 
             980                985                990
Arg Gly Glu Pro Gln Lys Gln Lys His Ser Lys Asp Asp Leu Lys Gly 
         995                1000                1005
Asp His Thr Lys Arg Ala Arg Glu Lys Ser Lys Ala Lys Lys Asp Lys 
     1010                1015                1020
Lys His Lys Ala Pro Lys Arg Lys Gln Ala Phe His Trp Gln Pro Pro 
 1025                1030                1035                1040
Leu Glu Phe Gly Asp Asp Glu Glu Glu Glu Met Asn Gly Lys Gln Val 
                 1045                1050                1055
Thr Gln Asp Pro Lys Glu Lys Arg His Val Ser Glu Lys Cys Glu Ala 
             1060                1065                1070
Val Lys Asp Gly Ile Pro Asn Val Glu Lys Thr Cys Asp Glu Gly Ser 
         1075                1080                1085
Ser Pro Ser Lys Pro Lys Lys Gly Thr Leu Glu Gln Asp Pro Leu Ala 
     1090                1095                1100
Glu Gly Gly His Asp Pro Ser Ser Cys Pro Ala Pro Leu Lys Val Glu 
 1105                1110                1115                1120
Asp Asn Thr Ala Ser Ser Pro Pro Ser Ala Gln His Leu Glu Glu His 
                 1125                1130                1135
Gly Pro Gly Gly Gly Glu Asp Val Leu Gln Thr Asp Asp Asn Met Glu 
             1140                1145                1150
Ile Cys Thr Pro Asp Arg Thr Ser Pro Ala Lys Gly Glu Val Val Ser 
         1155                1160                1165
Pro Leu Ala Asn His Arg Leu Asp Ser Pro Glu Val Asn Ile Ile Pro 
     1170                1175                1180
Glu Gln Asp Glu Cys Met Ala His Pro Arg Ala Gly Gly Glu Gln Glu 
 1185                1190                1195                1200
Ser Ser Met Ser Glu Ser Lys Thr Leu Gly Glu Ser Gly Val Lys Gln 
                 1205                1210                1215
Asp Ser Ser Thr Ser Val Thr Ser Pro Val Glu Thr Ser Gly Lys Lys 
             1220                1225                1230
Glu Gly Ala Glu Lys Ser Gln Met Asn Leu Thr Asp Lys Trp Lys Pro 
         1235                1240                1245
Leu Gln Gly Val Gly Asn Leu Ser Val Ser Thr Ala Thr Thr Ser Ser 
     1250                1255                1260
Ala Leu Asp Val Lys Ala Leu Ser Thr Val Pro Glu Val Lys Pro Gln 
 1265                1270                1275                1280
Gly Leu Arg Ile Glu Ile Lys Ser Lys Asn Lys Val Arg Pro Gly Ser 
                 1285                1290                1295
Leu Phe Asp Glu Val Arg Lys Thr Ala Arg Leu Asn Arg Arg Pro Arg 
             1300                1305                1310
Asn Gln Glu Ser Ser Ser Asp Asp Gln Thr Pro Ser Arg Asp Gly Asp 
         1315                1320                1325
Ser Gln Ser Arg Ser Pro His Arg Ser Arg Ser Lys Ser Glu Thr Lys 
     1330                1335                1340
Ser Arg His Arg Thr Arg Ser Val Ser Tyr Ser His Ser Arg Ser Arg 
 1345                1350                1355                1360
Ser Arg Ser Ser Thr Ser Ser Tyr Arg Ser Arg Ser Tyr Ser Arg Ser 
                 1365                1370                1375
Arg Ser Arg Asp Trp Tyr Ser Arg Gly Arg Thr Arg Ser Arg Ser Ser 
             1380                1385                1390
Ser Tyr Gly Ser Phe His Ser His Arg Thr Ser Ser Arg Ser Arg Ser 
         1395                1400                1405
Arg Ser Ser Ser Tyr Asp Leu His Ser Arg Ser Arg Ser Tyr Thr Tyr 
     1410                1415                1420
Asp Ser Tyr Tyr Ser Arg Ser Arg Ser Arg Ser Arg Ser Gln Arg Ser 
 1425                1430                1435                1440
Asp Ser Tyr His Arg Gly Arg Ser Tyr Asn Arg Arg Ser Arg Ser Gly 
                 1445                1450                1455
Arg Ser Tyr Gly Ser Asp Ser Glu Ser Asp Arg Ser Tyr Ser His His 
             1460                1465                1470
Arg Ser Pro Ser Glu Ser Ser Arg Tyr Ser 
         1475                1480



<210> 4552
<211> 550
<212> DNA
<213> Homo sapiens
<308> AI628792
<400> 4552

ttttttatt  tttttttta  actaaggat  tattttaat  tctacaagg  cccctttca  60
gttttaggg  aatttaact  aagtgtata  aaattagac  ttgctaata  gtacaaaag  120
attttatac  gtttttgaa  gatactagc  atttgcaat  aacaggatg  tacaaaaac  180
gtccaataa  gcatttcct  ttaagaagc  caatacaca  cataattca  ttttattaa  240
aaaataact  caaaatgta  aacaatccc  tttaggaag  aaagctatt  ctgtagttc  300
ctctgtcag  aaacacaca  gttgaacgc  gcagcagag  gctgtcttt  tccatggag  360
aaagaaatg  ggcttctag  gcctatctt  tctgggtaa  aattccacc  acagctgag  420
tgggcagtt  ttgcctgtg  taggcagaa  ttgaaaatg  ccctccccc  ttcaatgag  480
taatctcca  aacccgtga  tatgatgag  tgagacagt  ctcctgcaa  tatgttcta  540
cgcacaatca  550



<210> 4553
<211> 656
<212> PRT
<213> Homo sapiens
<308> A47328
<400> 4553

Met Val Asn Glu Ala Arg Gly Asn Ser Ser Leu Asn Pro Cys Leu Glu 
  1               5                  10                  15
Gly Ser Ala Ser Ser Gly Ser Glu Ser Ser Lys Asp Ser Ser Arg Cys 
             20                  25                  30
Ser Thr Pro Gly Leu Asp Pro Glu Arg His Glu Arg Leu Arg Glu Lys 
         35                  40                  45
Met Arg Arg Arg Leu Glu Ser Gly Asp Lys Trp Phe Ser Leu Glu Phe 
     50                  55                  60
Phe Pro Pro Arg Thr Ala Glu Gly Ala Val Asn Leu Ile Ser Arg Phe 
 65                  70                  75                  80
Asp Arg Met Ala Ala Gly Gly Pro Leu Tyr Ile Asp Val Thr Trp His 
                 85                  90                  95
Pro Ala Gly Asp Pro Gly Ser Asp Lys Glu Thr Ser Ser Met Met Ile 
             100                105                110
Ala Ser Thr Ala Val Asn Tyr Cys Gly Leu Glu Thr Ile Leu His Met 
         115                120                125
Thr Cys Cys Arg Gln Arg Leu Glu Glu Ile Thr Gly His Leu His Lys 
     130                135                140
Ala Lys Gln Leu Gly Leu Lys Asn Ile Met Ala Leu Arg Gly Asp Pro 
 145                150                155                160
Ile Gly Asp Gln Trp Glu Glu Glu Glu Gly Gly Phe Asn Tyr Ala Val 
                 165                170                175
Asp Leu Val Lys His Ile Arg Ser Glu Phe Gly Asp Tyr Phe Asp Ile 
             180                185                190
Cys Val Ala Gly Tyr Pro Lys Gly His Pro Glu Ala Gly Ser Phe Glu 
         195                200                205
Ala Asp Leu Lys His Leu Lys Glu Lys Val Ser Ala Gly Ala Asp Phe 
     210                215                220
Ile Ile Thr Gln Leu Phe Phe Glu Ala Asp Thr Phe Phe Arg Phe Val 
 225                230                235                240
Lys Ala Cys Thr Asp Met Gly Ile Thr Cys Pro Ile Val Pro Gly Ile 
                 245                250                255
Phe Pro Ile Gln Gly Tyr His Ser Leu Arg Gln Leu Val Lys Leu Ser 
             260                265                270
Lys Leu Glu Val Pro Gln Glu Ile Lys Asp Val Ile Glu Pro Ile Lys 
         275                280                285
Asp Asn Asp Ala Ala Ile Arg Asn Tyr Gly Ile Glu Leu Ala Val Ser 
     290                295                300
Leu Cys Gln Glu Leu Leu Ala Ser Gly Leu Val Pro Gly Leu His Phe 
 305                310                315                320
Tyr Thr Leu Asn Arg Glu Met Ala Thr Thr Glu Val Leu Lys Arg Leu 
                 325                330                335
Gly Met Trp Thr Glu Asp Pro Arg Arg Pro Leu Pro Trp Ala Leu Ser 
             340                345                350
Ala His Pro Lys Arg Arg Glu Glu Asp Val Arg Pro Ile Phe Trp Ala 
         355                360                365
Ser Arg Pro Lys Ser Tyr Ile Tyr Arg Thr Gln Glu Trp Asp Glu Phe 
     370                375                380
Pro Asn Gly Arg Trp Gly Asn Ser Ser Ser Pro Ala Phe Gly Glu Leu 
 385                390                395                400
Lys Asp Tyr Tyr Leu Phe Tyr Leu Lys Ser Lys Ser Pro Lys Glu Glu 
                 405                410                415
Leu Leu Lys Met Trp Gly Glu Glu Leu Thr Ser Glu Ala Ser Val Phe 
             420                425                430
Glu Val Phe Val Leu Tyr Leu Ser Gly Glu Pro Asn Arg Asn Gly His 
         435                440                445
Lys Val Thr Cys Leu Pro Trp Asn Asp Glu Pro Leu Ala Ala Glu Thr 
     450                455                460
Ser Leu Leu Lys Glu Glu Leu Leu Arg Val Asn Arg Gln Gly Ile Leu 
 465                470                475                480
Thr Ile Asn Ser Gln Pro Asn Ile Asn Gly Lys Pro Ser Ser Asp Pro 
                 485                490                495
Ile Val Gly Trp Gly Pro Ser Gly Gly Tyr Val Phe Gln Lys Ala Tyr 
             500                505                510
Leu Glu Phe Phe Thr Ser Arg Glu Thr Ala Glu Ala Leu Leu Gln Val 
         515                520                525
Leu Lys Lys Tyr Glu Leu Arg Val Asn Tyr His Leu Val Asn Val Lys 
     530                535                540
Gly Glu Asn Ile Thr Asn Ala Pro Glu Leu Gln Pro Asn Ala Val Thr 
 545                550                555                560
Trp Gly Ile Phe Pro Gly Arg Glu Ile Ile Gln Pro Thr Val Val Asp 
                 565                570                575
Pro Val Ser Phe Met Phe Trp Lys Asp Glu Ala Phe Ala Leu Trp Ile 
             580                585                590
Glu Arg Trp Gly Lys Leu Tyr Glu Glu Glu Ser Pro Ser Arg Thr Ile 
         595                600                605
Ile Gln Tyr Ile His Asp Asn Tyr Phe Leu Val Asn Leu Val Asp Asn 
     610                615                620
Asp Phe Pro Leu Asp Asn Cys Leu Trp Gln Val Val Glu Asp Thr Leu 
 625                630                635                640
Glu Leu Leu Asn Arg Pro Thr Gln Asn Ala Arg Glu Thr Glu Ala Pro 
                 645                650                655



<210> 4554
<211> 523
<212> DNA
<213> Rattus norvegicus
<308> AA799893
<400> 4554

aaaaagttt  ttgtaaaaa  agtaagcca  tcacaaaat  gaatgattt  tagcagtac  60
gctaaaacc  aactgcatg  cagtgagaa  tagtagagt  gcccagaat  aaggctctt  120
tcttaagga  gttcctttt  gccaataac  tctgtagca  gttttttaa  caaatttta  180
gacagcagt  aagcctcat  gcagattcc  tcctaaaaa  gcaaacaac  tttagaact  240
gccttttgt  gggccaatt  ccatcatta  actagtccc  ccccctccc  ttaacaatc  300
acccaccct  ccaccattt  ggggaaatg  atctaatat  actttgagc  attgcttta  360
gaaaatggg  caaaggaag  ttaaataaa  ttaaagggc  aaaacatat  gtcacaata  420
aaatgtatt  attcccttc  agtaggact  aataggcat  aattaaata  aaacaattc  480
tctccagaa  aaccaagtg  agcttaact  gactagttt  ggc  523



<210> 4555
<211> 523
<212> DNA
<213> Rattus norvegicus
<308> AA799893
<400> 4555

aaaaagttt  ttgtaaaaa  agtaagcca  tcacaaaat  gaatgattt  tagcagtac  60
gctaaaacc  aactgcatg  cagtgagaa  tagtagagt  gcccagaat  aaggctctt  120
tcttaagga  gttcctttt  gccaataac  tctgtagca  gttttttaa  caaatttta  180
gacagcagt  aagcctcat  gcagattcc  tcctaaaaa  gcaaacaac  tttagaact  240
gccttttgt  gggccaatt  ccatcatta  actagtccc  ccccctccc  ttaacaatc  300
acccaccct  ccaccattt  ggggaaatg  atctaatat  actttgagc  attgcttta  360
gaaaatggg  caaaggaag  ttaaataaa  ttaaagggc  aaaacatat  gtcacaata  420
aaatgtatt  attcccttc  agtaggact  aataggcat  aattaaata  aaacaattc  480
tctccagaa  aaccaagtg  agcttaact  gactagttt  ggc  523



<210> 4556
<211> 452
<212> DNA
<213> Rattus norvegicus
<308> AA799964
<400> 4556

ggtaaacaa  atttaatgt  accatatag  caaataatg  ttaaaagac  ttagataca  60
cttttaaaa  tttaaacta  ggaagaagt  caattaaac  aaaacgtaa  catttacta  120
actgcagcg  aactgagga  aaggacgta  aaaacattc  tttctcact  tgaagattc  180
aactctagg  aagaggtgt  cggcagtta  agtaaagca  atacacttg  tcagatctg  240
aagtcttac  tcagctctg  aggcttaga  actgcaggg  gtaggggtg  gggtgggga  300
atgaagagg  agttgcttt  tcaaaaagc  tagagcaga  ctattgata  aatgacaag  360
agaaataac  acacgtact  ttttcacta  ttcaaatga  cttaggaga  cctaatggg  420
atttaactg  gtagtttac  gagcaccta  gt  452



<210> 4557
<211> 2550
<212> DNA
<213> Homo sapiens
<308> AK024270
<400> 4557

tttagcagt  tgtgatgat  agcaaaaaa  cacataaag  aaaaattag  tgaccatgc  60
aaattcaat  ctggaattt  tttttattt  ggcatttct  gaacttttt  catttgaaa  120
tacatgatg  gtattagta  cgatgactt  tgtataatc  gaatcttta  gacaattta  180
ttttacaag  tcaaaagag  tgagtttgc  aaacccagc  gtgatacct  agttggaaa  240
ggaattcaa  ggtatgctt  gtagaacag  aaagtatag  ttttttttc  tgaacttta  300
tcattttct  tttttcctc  atgtgagtc  gctacaaaa  tggtctaat  tttacaaca  360
tagaacttc  tccttttct  ctgtaatct  cccactgac  ttactgcac  ggtatgaaa  420
actagtgta  tggatcttc  gtaaccttt  tatttccta  atgattgaa  tataggtat  480
tactccatt  aaaccaggt  ataagatga  gtaaatact  agggagggt  ttaacttgt  540
acttttgct  gtttggggt  taaagtgcc  tgactgaat  atcttcaat  catgattct  600
gagtaagtt  aatttggaa  aaggggctt  acacatggt  gtggttgaa  attgattct  660
ttatactta  aaagatgaa  atgttttgt  gactgatac  ttttatctt  ctgaatatg  720
attgtttat  tatctctac  gtcaaatag  ctttttgaa  ctcaggaaa  acaaaggtt  780
aattacacc  cttttgtca  taagcaaac  aggtatttt  tttttctcc  gttgtctgg  840
tatggcaat  gatttttta  attgctgtg  gaacccata  atgaaaaga  aggagttga  900
ttgtgtgtg  cttttatgt  ttgagattt  tatgtggaa  agacgacat  tacttcaaa  960
tgtattttt  tcgtttttt  ttttttttg  ggaaggggg  agaacgggg  cttgctctg  1020
cgcccaggc  ggagtgcag  ggcgcgatc  cagctgact  caacctcca  ctcccgggt  1080
caagggatt  tgcctcagc  tcccgagta  ctgagacca  aggtgcgtg  caccacacc  1140
ggctaattt  tttgtattt  tagtagaga  ggggtttag  agagacgga  cactcctga  1200
cacgtgatc  gcccacctc  gcctcccaa  gtgctggga  tacaggcgt  agccaccac  1260
cccggcctg  attttcaga  aggagagct  ggtgttttt  tggtgccaa  tggtaagat  1320
atgtctctt  gaggcttcc  atggactgc  tttatttta  taaactcaa  acaccagtt  1380
acctcaaca  agttttggc  ttattagaa  ttgttgtgc  tcttattga  agccaggtt  1440
acatcacct  accccatta  tctttttag  taaataaat  taccatgcc  agtaaccag  1500
atggagcaa  ttggttgat  tttaaggca  taggtttga  tagctagct  tcattattg  1560
cacatctaa  gctaggcac  agaaaccat  tgagccagg  gtgtgaatg  ataattcca  1620
agacacttt  gacattttt  aatgtttta  atgaacatt  tacatttgt  tgattgcct  1680
agatattaa  ttttcctag  gctgataaa  acagcaaca  tcataactt  ttttatata  1740
tgttccaaa  aaaagaatt  gttttaatg  tttcaaaat  actgcacct  aatttgttt  1800
tgtgcctta  gttctctag  gctatttca  ctttttttt  aatctaaat  aagcttacc  1860
tagataagg  tcatatttg  ttcctatag  gtaaataaa  ttccccttc  taaattgtg  1920
aataagcac  aacgtgtgg  tgcttggca  aatgagaat  ttaagggag  ttgttggat  1980
tttggagtt  cattatatt  tttgttttt  ttttttgat  cctaggtgc  ttttaaaat  2040
ttcagacaa  tatctatct  acattgatt  aacccgtgt  aattcattt  cagtatcta  2100
atcgaatgt  aaaaaagta  acttatttt  gttccatac  tatgtacaa  tttttccct  2160
ttcaggctt  ttcatttac  tttttgaaa  agcacttac  ctccccttc  ctatcaccc  2220
tcccccaag  tttctttat  taaattttt  ttgagagtt  ttggagctc  aagacaata  2280
aaatttaga  ttgaacaaa  gtataatct  ctttacaac  agtatagac  taaggtcat  2340
tgctttcaa  tagaggctc  agagtcttc  tagtggaaa  aatgctttg  atttaattg  2400
tcttagtta  gttgtagca  gtgaatact  acttacatg  tttgtttaa  tatacttct  2460
gcatagttt  attttttaa  agttgtatc  aataaaatg  cttttaacc  ttattactt  2520
actatatgg  tgtattaaa  tttgtttacg  2550



<210> 4558
<211> 551
<212> DNA
<213> Rattus norvegicus
<308> AA799980
<400> 4558

gaaaatcac  ccaaaaagt  ctatgtcag  ctgtttaaa  tcgatcctt  attcaggta  60
caagttgcc  atggtcacc  tattgtagg  aacatcaga  taccatcct  gaagggact  120
tgagtacag  tgggatcag  ggggacagg  taacaatga  ccatttgca  tcttcctcc  180
catctttta  caaccccca  acccccagt  aagggacaa  tagttttta  caccatcat  240
tgaagcact  caactgaca  ggctaaaat  taaagaata  ataaaatat  ttgtggcag  300
aattccttt  agagcaaaa  tcaggtgca  aagaaatca  gtgatcagg  aaactgtat  360
cgaatgtgt  gctccccaa  cacagcctc  ggaaaatga  acagaaaat  ccatacatt  420
catttcata  aggaccaga  aatgactca  gttcagcta  acacagagg  aattacaac  480
tgctgaaac  caattaaaa  atggggaaa  gtttacaaa  catccacaa  atgtaaatc  540
tgtacagat  g  551



<210> 4559
<211> 390
<212> PRT
<213> Rattus norvegicus
<308> S20392
<400> 4559

Met Gly Ala Phe Leu Asp Lys Pro Lys Thr Glu Lys His Asn Ala His 
  1               5                  10                  15
Gly Ala Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
             20                  25                  30
Arg Val Glu Met Glu Asp Ala His Thr Ala Val Val Gly Ile Pro His 
         35                  40                  45
Gly Leu Glu Asp Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
     50                  55                  60
Ser Arg Val Ala Asn Tyr Cys Ser Thr His Leu Leu Glu His Ile Thr 
 65                  70                  75                  80
Thr Asn Glu Asp Phe Arg Ala Ala Asp Lys Ser Gly Phe Ala Leu Glu 
                 85                  90                  95
Pro Ser Val Glu Asn Val Lys Thr Gly Ile Arg Thr Gly Phe Leu Lys 
             100                105                110
Ile Asp Glu Tyr Met Arg Asn Phe Ser Asp Leu Arg Asn Gly Met Asp 
         115                120                125
Arg Ser Gly Ser Thr Ala Val Gly Val Met Ile Ser Pro Thr His Ile 
     130                135                140
Tyr Phe Ile Asn Cys Gly Asp Ser Arg Ala Val Leu Cys Arg Asn Gly 
 145                150                155                160
Gln Val Cys Phe Ser Thr Gln Asp His Lys Pro Cys Asn Pro Met Glu 
                 165                170                175
Lys Glu Arg Ile Gln Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val 
             180                185                190
Asn Gly Ser Leu Ala Val Ser Arg Ala Leu Gly Asp Tyr Asp Tyr Lys 
         195                200                205
Cys Val Asp Gly Lys Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro 
     210                215                220
Glu Val Tyr Glu Ile Leu Arg Ala Glu Glu Asp Glu Phe Val Val Leu 
 225                230                235                240
Ala Cys Asp Gly Ile Trp Asp Val Met Ser Asn Glu Glu Leu Cys Glu 
                 245                250                255
Phe Val Asn Ser Arg Leu Glu Val Ser Asp Asp Leu Glu Asn Val Cys 
             260                265                270
Asn Trp Val Val Asp Thr Cys Leu His Lys Gly Ser Arg Asp Asn Met 
         275                280                285
Ser Ile Val Leu Val Cys Phe Ala Asn Ala Pro Lys Val Ser Asp Glu 
     290                295                300
Ala Val Lys Arg Asp Leu Glu Leu Asp Lys His Leu Glu Ser Arg Val 
 305                310                315                320
Glu Glu Ile Met Gln Lys Ser Gly Glu Glu Gly Met Pro Asp Leu Ala 
                 325                330                335
His Val Met Arg Ile Leu Ser Ala Glu Asn Ile Pro Asn Leu Pro Pro 
             340                345                350
Gly Gly Gly Leu Ala Gly Lys Arg Asn Val Ile Glu Ala Val Tyr Ser 
         355                360                365
Arg Leu Asn Pro Asn Lys Asp Asn Asp Gly Gly Ala Gly Asp Leu Glu 
     370                375                380
Asp Ser Leu Val Ala Leu 
 385                390



<210> 4560
<211> 382
<212> DNA
<213> Homo sapiens
<308> AW665936
<400> 4560

tttgagaca  agccttggt  tgtcgccca  gcgacaaaa  tgctaggat  acaggcatg  60
gctaccgtg  ctggcctgt  tatattttt  aaaagcatt  gtcttacct  caacccgtg  120
ttccaagtg  ttatccaac  ctgaatctt  tttcaccgc  tcatctgag  ccttgggag  180
atttgaaaa  caaactagt  caatactca  gttatctcg  cttccctgt  tattaaaga  240
aaaaaagaa  aaaaattgt  tttctacaa  caactatta  ttactttaa  atactttaa  300
caattatag  ttatttaat  atccagaac  tttatgttt  acacattca  ttttattcc  360
atgaattac  aaaaacaca  ct  382



<210> 4561
<211> 479
<212> PRT
<213> Homo sapiens
<308> O75688
<400> 4561

Met Gly Ala Phe Leu Asp Lys Pro Lys Thr Glu Lys His Asn Ala His 
  1               5                  10                  15
Gly Ala Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
             20                  25                  30
Arg Val Glu Met Glu Asp Ala His Thr Ala Val Val Gly Ile Pro His 
         35                  40                  45
Gly Leu Glu Asp Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
     50                  55                  60
Ser Arg Val Ala Asn Tyr Cys Ser Thr His Leu Leu Glu His Ile Thr 
 65                  70                  75                  80
Thr Asn Glu Asp Phe Arg Ala Ala Gly Lys Ser Gly Ser Ala Leu Glu 
                 85                  90                  95
Leu Ser Val Glu Asn Val Lys Asn Gly Ile Arg Thr Gly Phe Leu Lys 
             100                105                110
Ile Asp Glu Tyr Met Arg Asn Phe Ser Asp Leu Arg Asn Gly Met Asp 
         115                120                125
Arg Ser Gly Ser Thr Ala Val Gly Val Met Ile Ser Pro Lys His Ile 
     130                135                140
Tyr Phe Ile Asn Cys Gly Asp Ser Arg Ala Val Leu Tyr Arg Asn Gly 
 145                150                155                160
Gln Val Cys Phe Ser Thr Gln Asp His Lys Pro Cys Asn Pro Arg Glu 
                 165                170                175
Lys Glu Arg Ile Gln Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val 
             180                185                190
Asn Gly Ser Leu Ala Val Ser Arg Ala Leu Gly Asp Tyr Asp Tyr Lys 
         195                200                205
Cys Val Asp Gly Lys Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro 
     210                215                220
Glu Val Tyr Glu Ile Leu Arg Ala Glu Glu Asp Glu Phe Ile Ile Leu 
 225                230                235                240
Ala Cys Asp Gly Ile Trp Asp Val Met Ser Asn Glu Glu Leu Cys Glu 
                 245                250                255
Tyr Val Lys Ser Arg Leu Glu Val Ser Asp Asp Leu Glu Asn Val Cys 
             260                265                270
Asn Trp Val Val Asp Thr Cys Leu His Lys Gly Ser Arg Asp Asn Met 
         275                280                285
Ser Ile Val Leu Val Cys Phe Ser Asn Ala Pro Lys Val Ser Asp Glu 
     290                295                300
Ala Val Lys Lys Asp Ser Glu Leu Asp Lys His Leu Glu Ser Arg Val 
 305                310                315                320
Glu Glu Ile Met Glu Lys Ser Gly Glu Glu Gly Met Pro Asp Leu Ala 
                 325                330                335
His Val Met Arg Ile Leu Ser Ala Glu Asn Ile Pro Asn Leu Pro Pro 
             340                345                350
Gly Gly Gly Leu Ala Gly Lys Arg Asn Val Ile Glu Ala Val Tyr Ser 
         355                360                365
Arg Leu Asn Pro His Arg Glu Ser Asp Gly Ala Ser Asp Glu Ala Glu 
     370                375                380
Glu Ser Gly Ser Gln Gly Lys Leu Val Glu Ala Leu Arg Gln Met Arg 
 385                390                395                400
Ile Asn His Arg Gly Asn Tyr Arg Gln Leu Leu Glu Glu Met Leu Thr 
                 405                410                415
Ser Tyr Arg Leu Ala Lys Val Glu Gly Glu Glu Ser Pro Ala Glu Pro 
             420                425                430
Ala Ala Thr Ala Thr Ser Ser Asn Ser Asp Ala Gly Asn Pro Val Thr 
         435                440                445
Met Gln Glu Ser His Thr Glu Ser Glu Ser Gly Leu Ala Glu Leu Asp 
     450                455                460
Ser Ser Asn Glu Asp Ala Gly Thr Lys Met Ser Gly Glu Lys Ile 
 465                470                475



<210> 4562
<211> 712
<212> DNA
<213> Rattus norvegicus
<308> AA799991
<400> 4562

acaatcagt  atataatca  atacacaat  atatacaag  attatatac  ttttgccca  60
acttttaca  cacagtaca  agtttccat  aaaaatatt  tttacattt  tcaccaaac  120
ataaaaccc  acaacagta  tgttacagc  cctgttagt  cagacagct  tttcataaa  180
tacatcata  gaaaatata  ggctgtaaa  tgggctttt  aaaatgtct  tttataaaa  240
ctgaacata  aatgtttca  tcacagaat  ttttttttt  tcaatgttc  gactgtacc  300
ttgtgcata  aacaaccag  tggaatatt  agtaaatgc  accctccct  taaaactat  360
agcactgtt  gaattactt  ggctgagct  tctttatga  gagtctggc  tggagtttg  420
tgagaaaac  acgctggct  tgctataan  aagtcatat  atggtaatt  aatctaaag  480
ttccaggaa  taatacata  ggaattgat  cagaaggca  attttcatt  gaatactac  540
cgtaagaaa  ggaaaggaa  tgcaataat  tccaaaagt  aaccttcgg  ccataaagg  600
tnagaaaaa  acattcaat  ccgccaaat  cagattaca  ctccattat  taggaaaat  660
aacagctaa  tcagggtta  ggaaacaca  tcaggaaat  tgctanacc  tg  712



<210> 4563
<211> 6298
<212> DNA
<213> Homo sapiens
<308> AF288393
<400> 4563

ccgcgttct  cctggtgtc  gccacctcc  tgtggacgg  gggggccga  cccatgagt  60
gggaggaga  acagaagct  gggaatcaa  tactggaaa  gtttgatca  gcttatggt  120
actatatgg  acatgctta  cctgctgat  aactcatgc  tttaacctg  agaggtcga  180
ttagaggcc  agagccaag  cgcggtgac  ttgatgatg  cttgggaaa  ttttctctg  240
cactgattg  ttctttgga  actcttgtg  ttttaaata  aactaaaga  tttgaagat  300
cagtgagaa  agttttaag  gatgttaat  tagataacg  tgtagtcgt  tcagtcttt  360
aaacaaaca  cagagttct  gggggtctt  tgggtgggc  ctccctggc  atcatgctg  420
aagaaaaag  tgaatatat  cagtggtac  atgatgaac  tctccaaat  gcaaagcag  480
taggttaca  acttttacc  gctttcaac  ctaccagtg  ccttcctta  ccaagaatt  540
atttaaagt  tggcatcag  aaaccagaa  ctcggacag  aactgagac  gatacctgt  600
cagcttgtg  aggtacctt  atccttgaa  ttgctgctt  aagtcgatt  acaggagca  660
caatatttg  ggaatatgc  agaaaagct  ttgattttc  ctgggaaaa  agacagcga  720
gtagtaatt  agtgggcgt  actataaat  ttcatactg  agattgggt  cgaaaagat  780
gtggagttg  agcagggat  gattcatat  atgaatatc  gttgaaagc  tatgtcttg  840
ttggagatg  cagttttct  gaaagattt  acacacact  tgatgccat  atgaggtat  900
ttagccagc  acctcttct  cttgatgtg  atatccaca  accaatgct  aatgctcgg  960
cttggatgg  tgctttgct  gccttcttc  caggcttgc  ggtgttaaa  ggggatatt  1020
gacctgcta  tgaaactca  gaaatgtta  atcaggtga  taaaaaaca  aattttcta  1080
cagaggcat  taccacaga  ttcagagta  actgggctc  acatccttt  aggccagaa  1140
ttgcagaaa  tacctactt  ttatataaa  ctacaggag  tccttacta  cttgaagta  1200
ggaagacac  tattgaaaa  ttaaataaa  atgctagag  gccttgcgg  tttgctgcc  1260
tgaaggatg  tcgtactgg  agtcatgag  acagaatgg  ttctttctt  ttggctgaa  1320
tgtttaaat  tctttacct  ttatttgct  ataaagaag  cattatttt  gacatagaa  1380
attacatct  tacaacaga  gctcatctg  tacctcttt  gctctctac  acaaatcaa  1440
gcatctcta  aaagaacac  acctcggaa  atacagaac  ggatgacag  aacttcgat  1500
ggacttgtc  aaatactca  atcctcttt  ctaatgacc  attgtatgc  caaagtatt  1560
gtgagccct  gaaaaatgt  gtggataag  gctgtccta  aggcatcat  agagtagag  1620
agagtttca  gagtggagc  aaaccccct  tgagagcca  agatttcat  gccactaac  1680
ctgagcatt  agaaatcct  aagaagatg  gggtgagtt  gattcacct  aaagatggg  1740
gagtccagt  ggtccaaca  gcaatccaa  ctgctagtt  aatcgacgc  gaagatggg  1800
tgaggttca  gcaggagat  attgaattg  caagtcagc  acaaaaaga  cagcagctg  1860
ctccacgag  tgtacaaat  gtttcccac  cattttttg  cagggtagt  ttgactgct  1920
gaccagctc  gtttgggct  gatctgtct  aacataaag  gacaagagg  tttgttgca  1980
gcagtaaac  atccaatgg  tgttcagag  ttactaacc  agaggcagt  atgggaaaa  2040
tcgcactga  acaaagagg  cagtgcatg  ttgcagaaa  ggcacgcaa  atccagaat  2100
ctggagcca  tggtggcat  gttattgat  acaatgagg  gagcagcag  gatactgcc  2160
ctctgttcc  gatggcagg  gatggaaag  atacagatg  catcaagat  cccatgctg  2220
tcttattca  caaagaagg  agtatcata  tggatgcca  ccgggaata  gaggaggta  2280
aagtgctcc  ctctgataa  gcaaaagat  gagatcctg  aatggaaaa  gaagaacaa  2340
catcctctg  aaatgattc  cagaatcag  gtggtgaac  gatttcatc  agttctcag  2400
aggttgatt  ggttgatca  gagtcttct  aggaaaatt  tctaaattc  cacccagaa  2460
cattatctc  agcagatat  gacaatgct  caagcattt  cccttctga  cagacttct  2520
atcccacag  aaaccatga  actacaaat  ttaatggtg  atgtacaga  ttagataac  2580
agcttcaag  acaatcaga  actgaggaa  attccaatc  taatgttag  tggggtaaa  2640
aggtccagc  tatagactc  atattagca  actggaatg  agatataga  gcatttgaa  2700
tgatggaga  ggatgagct  tgacttgct  aacaatctg  tggtaggta  ttaaaaaga  2760
aaggtaaac  gtgtgtggt  aatagacat  ctaatacta  gcaggcttt  taatgggag  2820
ctttaagta  ggtgatgaa  aaccacgtt  tgactggcg  agttatcgt  ggaatctgg  2880
gcatgctgt  ttagaattg  ccttgttta  aactgtccc  tcaaaaatg  aaatccaca  2940
ttccccctt  aaatgcagc  ctgcaccac  ctgcaacac  tcaggccag  gaaagatta  3000
tgagcattc  tgcgaacca  atttctgtt  tctctggat  gacaagaaa  aaaattcat  3060
tagtagtgg  gtggggaat  ggagtttgg  tagccttct  attaaagga  gctcgcctt  3120
cttggtttt  ggggttaga  gctcttttg  gaagatgca  ccgagtatt  tggcattct  3180
attatgctg  cttcacaaa  cactctaag  gacctaagt  gttatgaag  aaatgcatt  3240
atggtgaaa  cagtctttg  tcattgctt  ctcttgttt  atttagtga  aaatgatca  3300
gatgacttg  ttttttttc  ttcttaaca  tgtcttttt  atttaaacc  aaggtgaag  3360
cagtgtact  tctcagtga  ttctctgca  aaagactaa  cagtgggac  aggtaaaaa  3420
gtcatataa  acattgtgg  gattgctta  ttaatactt  tgaaaaatg  agtaaggga  3480
aaactgtaa  gttgcaata  gaacctccc  ttgggcctt  catagggaa  gctgtgact  3540
ctctgaaat  gaacctagc  ttatatcct  gtagggtag  ttataaatc  tttccagtt  3600
atttctctt  gaggtgatt  cctctagcc  tcagcctta  tccatccca  gtttggtat  3660
caatttgag  cacaaggct  gtatcgcca  cagctatat  cattttgtt  catttttct  3720
tcttacaga  ccatgataa  actgtggtt  gtgagttaa  attcctgga  taactactg  3780
ttttctcct  tgaaactta  gtttctaaa  ttgcaccta  ggaatctgt  acattttct  3840
ttgaatcat  gtttttgtt  ttgttttta  cagatattc  ttctgatac  gacttgaaa  3900
ttagtgtat  gtgacctgt  tttaaaaaa  aaagtacaa  acaactaca  atagctata  3960
agcttaatg  gacttccac  ccccccccc  ttttttttt  gtttgttgt  gttgtagta  4020
tctggtgct  gccacattt  agtcttaaa  atttttaaa  tttgttgtt  atgtttgta  4080
acagccctg  tgttgaaat  atggcttta  tcattttat  tatttttta  acttgcctg  4140
atttgttct  aaggaatat  taagagaca  aattttctt  tctttacca  aacattaca  4200
aaaactttt  cctaaaaca  ggttgtgag  tactgatga  gtgtaagtg  agctgttaa  4260
aacagcagt  ctgtattgc  gttatgtat  ttcgtgtac  gtatgttta  atcccaggt  4320
aacatattc  tttctgaga  gataaatac  tgcattcag  tattccagg  aaatataat  4380
gagtcaggg  gtagtaaat  tgatggaga  ttcactttg  ggaggggaa  aagaatagt  4440
tgcaagacc  ttattggct  ttaattata  ctgaaacca  aatggatat  tttagtctc  4500
ctgcatgtg  gatttggtg  aacaagata  aactataat  tatacagta  atggaagga  4560
agatatagt  ctttgttca  tttaattgc  aagctgcca  aatagttga  gcttaatta  4620
ttgacttgc  ttgatttat  ggactgggg  ttggagaaa  tgagcagat  ttcctctaa  4680
acatcgatt  cagaagcct  atatacatg  atttgattt  gtatttgta  ctgaaagtc  4740
ctgttgtct  aaactaact  ttctaagtt  tcaaaacaa  ctaatttct  ttccaacaa  4800
gagaactta  tggcatgaa  gattgtgtg  cacattgga  aagccagct  actgccact  4860
tcttccttt  gccattaga  ggaggtgtt  cctttcatt  acgcttaga  gcaaattgt  4920
cacttgtta  gaaaagtaa  tccttaaaa  aagaaaagg  aaaaattta  ccaattttt  4980
ttaataccc  gaaggaatt  tactcaata  ttccctagt  aagaaaaga  gagataatg  5040
tcgtctaaa  aactccaac  ttgtaatta  aactctaca  tcatttact  acttgacat  5100
ctgccacaa  gtagttttt  agttcatta  aaattccaa  ggcattagt  gtttttttt  5160
ttttttagt  ttttgtttt  tagttaact  ttatagaca  tttagtaac  tgctaaaga  5220
tcaggggat  ctatgaacc  cgaatttag  aacatctgg  ctacctcag  taaatgttg  5280
ctgcttaga  atatagctg  agtgatcac  acagccata  aattgttta  gaaagattt  5340
tataatgtt  acaaatctg  aatcaagga  tttagctga  atcctttaa  agatattag  5400
gcaagtatt  aattcaggt  ttttcaagt  ttaaaactt  acctgttta  ctacttaaa  5460
ataaaatag  tagtttttt  ctgcatata  aagttcatt  aaatgatat  cccttattt  5520
caatacttt  cccataaag  tttaagtgt  aaagaattg  aatttacta  atatgtttg  5580
tatgggata  tttgttagg  aagttttct  ttttcttct  aaattgcaa  aggcttcca  5640
aaagagtat  attgtttca  aacaaatta  ctcttggca  tatacgtct  cctttttct  5700
tacagtatt  gtaaaaaga  aaattgtac  ctttctgat  ttaacttca  taatgtaat  5760
actctctca  gaagctttt  aaatttaaa  taccatcac  caacctttt  tatagtaaa  5820
ccaacattt  ttctctcac  aaaccccat  ccaaattca  catgaagaa  gctcagcat  5880
agtaattca  atactgctt  taattttag  ggggggtag  atttagtaa  tattccagc  5940
ggtcgtttt  tgcacaagg  ttcagtcag  acatagaaa  aaaaaacat  ctgtgaatg  6000
aatattgta  gttcagatt  tataaaaga  atttttaaa  gcccaattt  cagccgtat  6060
ttttcttat  atgtaattt  tgaaaaaga  gtctgtact  acaggtgct  taacactac  6120
gttgttgga  tttattgtt  ggtgataaa  gtatacaat  tttctaagg  aaactatgt  6180
ctgtgatgt  aaagtctgg  caaaatgta  ataatcctg  atataatta  gtatttgat  6240
ataattact  attgtaaag  tttaataaa  tatgtaaat  ttccaaaaa  aaaaaaaa  6298



<210> 4564
<211> 889
<212> PRT
<213> Homo sapiens
<308> Q9BZQ6
<400> 4564

Met Ser Arg Glu Glu Lys Gln Lys Leu Gly Asn Gln Val Leu Glu Met 
  1               5                  10                  15
Phe Asp His Ala Tyr Gly Asn Tyr Met Glu His Ala Tyr Pro Ala Asp 
             20                  25                  30
Glu Leu Met Pro Leu Thr Cys Arg Gly Arg Val Arg Gly Gln Glu Pro 
         35                  40                  45
Ser Arg Gly Asp Val Asp Asp Ala Leu Gly Lys Phe Ser Leu Thr Leu 
     50                  55                  60
Ile Asp Ser Leu Asp Thr Leu Val Val Leu Asn Lys Thr Lys Glu Phe 
 65                  70                  75                  80
Glu Asp Ala Val Arg Lys Val Leu Arg Asp Val Asn Leu Asp Asn Asp 
                 85                  90                  95
Val Val Val Ser Val Phe Glu Thr Asn Ile Arg Val Leu Gly Gly Leu 
             100                105                110
Leu Gly Gly His Ser Leu Ala Ile Met Leu Lys Glu Lys Gly Glu Tyr 
         115                120                125
Met Gln Trp Tyr Asn Asp Glu Leu Leu Gln Met Ala Lys Gln Leu Gly 
     130                135                140
Tyr Lys Leu Leu Pro Ala Phe Asn Thr Thr Ser Gly Leu Pro Tyr Pro 
 145                150                155                160
Arg Ile Asn Leu Lys Phe Gly Ile Arg Lys Pro Glu Ala Arg Thr Gly 
                 165                170                175
Thr Glu Thr Asp Thr Cys Thr Ala Cys Ala Gly Thr Leu Ile Leu Glu 
             180                185                190
Phe Ala Ala Leu Ser Arg Phe Thr Gly Ala Thr Ile Phe Glu Glu Tyr 
         195                200                205
Ala Arg Lys Ala Leu Asp Phe Leu Trp Glu Lys Arg Gln Arg Ser Ser 
     210                215                220
Asn Leu Val Gly Val Thr Ile Asn Ile His Thr Gly Asp Trp Val Arg 
 225                230                235                240
Lys Asp Ser Gly Val Gly Ala Gly Ile Asp Ser Tyr Tyr Glu Tyr Leu 
                 245                250                255
Leu Lys Ala Tyr Val Leu Leu Gly Asp Asp Ser Phe Leu Glu Arg Phe 
             260                265                270
Asn Thr His Tyr Asp Ala Ile Met Arg Tyr Ile Ser Gln Pro Pro Leu 
         275                280                285
Leu Leu Asp Val His Ile His Lys Pro Met Leu Asn Ala Arg Thr Trp 
     290                295                300
Met Asp Ala Leu Leu Ala Phe Phe Pro Gly Leu Gln Val Leu Lys Gly 
 305                310                315                320
Asp Ile Arg Pro Ala Ile Glu Thr His Glu Met Leu Tyr Gln Val Ile 
                 325                330                335
Lys Lys His Asn Phe Leu Pro Glu Ala Phe Thr Thr Asp Phe Arg Val 
             340                345                350
His Trp Ala Gln His Pro Leu Arg Pro Glu Phe Ala Glu Ser Thr Tyr 
         355                360                365
Phe Leu Tyr Lys Ala Thr Gly Asp Pro Tyr Tyr Leu Glu Val Gly Lys 
     370                375                380
Thr Leu Ile Glu Asn Leu Asn Lys Tyr Ala Arg Val Pro Cys Gly Phe 
 385                390                395                400
Ala Ala Met Lys Asp Val Arg Thr Gly Ser His Glu Asp Arg Met Asp 
                 405                410                415
Ser Phe Phe Leu Ala Glu Met Phe Lys Tyr Leu Tyr Leu Leu Phe Ala 
             420                425                430
Asp Lys Glu Asp Ile Ile Phe Asp Ile Glu Asp Tyr Ile Phe Thr Thr 
         435                440                445
Glu Ala His Leu Leu Pro Leu Trp Leu Ser Thr Thr Asn Gln Ser Ile 
     450                455                460
Ser Lys Lys Asn Thr Thr Ser Glu Tyr Thr Glu Leu Asp Asp Ser Asn 
 465                470                475                480
Phe Asp Trp Thr Cys Pro Asn Thr Gln Ile Leu Phe Pro Asn Asp Pro 
                 485                490                495
Leu Tyr Ala Gln Ser Ile Arg Glu Pro Leu Lys Asn Val Val Asp Lys 
             500                505                510
Ser Cys Pro Arg Gly Ile Ile Arg Val Glu Glu Ser Phe Arg Ser Gly 
         515                520                525
Ala Lys Pro Pro Leu Arg Ala Arg Asp Phe Met Ala Thr Asn Pro Glu 
     530                535                540
His Leu Glu Ile Leu Lys Lys Met Gly Val Ser Leu Ile His Leu Lys 
 545                550                555                560
Asp Gly Arg Val Gln Leu Val Gln His Ala Ile Gln Ala Ala Ser Ser 
                 565                570                575
Ile Asp Ala Glu Asp Gly Leu Arg Phe Met Gln Glu Met Ile Glu Leu 
             580                585                590
Ser Ser Gln Gln Gln Lys Glu Gln Gln Leu Pro Pro Arg Ala Val Gln 
         595                600                605
Ile Val Ser His Pro Phe Phe Gly Arg Val Val Leu Thr Ala Gly Pro 
     610                615                620
Ala Gln Phe Gly Leu Asp Leu Ser Lys His Lys Glu Thr Arg Gly Phe 
 625                630                635                640
Val Ala Ser Ser Lys Pro Ser Asn Gly Cys Ser Glu Leu Thr Asn Pro 
                 645                650                655
Glu Ala Val Met Gly Lys Ile Ala Leu Ile Gln Arg Gly Gln Cys Met 
             660                665                670
Phe Ala Glu Lys Ala Arg Asn Ile Gln Asn Ala Gly Ala Ile Gly Gly 
         675                680                685
Ile Val Ile Asp Asp Asn Glu Gly Ser Ser Ser Asp Thr Ala Pro Leu 
     690                695                700
Phe Gln Met Ala Gly Asp Gly Lys Asp Thr Asp Asp Ile Lys Ile Pro 
 705                710                715                720
Met Leu Phe Leu Phe Ser Lys Glu Gly Ser Ile Ile Leu Asp Ala Ile 
                 725                730                735
Arg Glu Tyr Glu Glu Val Glu Val Leu Leu Ser Asp Lys Ala Lys Asp 
             740                745                750
Arg Asp Pro Glu Met Glu Asn Glu Glu Gln Pro Ser Ser Glu Asn Asp 
         755                760                765
Ser Gln Asn Gln Ser Gly Glu Gln Ile Ser Ser Ser Ser Gln Glu Val 
     770                775                780
Asp Leu Val Asp Gln Glu Ser Ser Glu Glu Asn Ser Leu Asn Ser His 
 785                790                795                800
Pro Glu Ser Leu Ser Leu Ala Asp Met Asp Asn Ala Ala Ser Ile Ser 
                 805                810                815
Pro Ser Glu Gln Thr Ser Asn Pro Thr Glu Asn His Glu Thr Thr Asn 
             820                825                830
Leu Asn Gly Glu Cys Thr Asp Leu Asp Asn Gln Leu Gln Glu Gln Ser 
         835                840                845
Glu Thr Glu Glu Asp Ser Asn Pro Asn Val Ser Trp Gly Lys Lys Val 
     850                855                860
Gln Pro Ile Asp Ser Ile Leu Ala Asp Trp Asn Glu Asp Ile Glu Ala 
 865                870                875                880
Phe Glu Met Met Glu Lys Asp Glu Leu 
                 885



<210> 4565
<211> 649
<212> DNA
<213> Rattus norvegicus
<308> AA800004
<400> 4565

gccacatat  ggttagttt  tttcctctg  gtctctgag  agtcagcag  gatataagg  60
gaactggta  gagctgcag  gggcctgag  agagctgat  cagggagag  ggccggcgt  120
ggctggtag  agagattta  atattcagg  ccaaaagcc  gttagtgag  ctccttcat  180
tgtctttgg  ttttgtgta  catctcctg  atccgccgc  gctcttcat  tttctcccg  240
atgagcttc  cagtttctg  atctgtccg  ttccgttcc  tcactacta  ccgggtcat  300
ctctggatg  actgtgccc  gtagttctc  tagtgtgtc  ctcgggtca  atcctttag  360
tcctgtaat  tgaagtcct  atcctcatc  gaatcacaa  ctgggaact  atagatctt  420
attccaaag  gctcgatct  ctcncggat  ttgcatttc  ttcggtcca  ttcagaggg  480
gtcagtgtg  ctgccttag  caagatagg  acaatgttg  cccgctgat  caggccctc  540
tgaattcag  atccaatgc  cggagcccg  ggccaaagg  gagatgagt  cagcagcat  600
cacctgttg  ctgatgttc  gcattcagg  agtccatct  gaaatctcg  649



<210> 4566
<211> 378
<212> PRT
<213> Rattus norvegicus
<308> BAA98051
<400> 4566

Met Asp Ser Leu Ala Ala Pro Gln Asp Arg Leu Val Glu Gln Leu Leu 
  1               5                  10                  15
Ser Pro Arg Thr Gln Ala Gln Arg Arg Leu Lys Asp Ile Asp Lys Gln 
             20                  25                  30
Tyr Val Gly Phe Ala Thr Leu Pro Asn Gln Val His Arg Lys Ser Val 
         35                  40                  45
Lys Lys Gly Phe Asp Phe Thr Leu Met Val Ala Gly Glu Ser Gly Leu 
     50                  55                  60
Gly Lys Ser Thr Leu Val His Ser Leu Phe Leu Thr Asp Leu Tyr Lys 
 65                  70                  75                  80
Asp Arg Lys Leu Leu Ser Ala Glu Glu Arg Ile Asn Gln Thr Val Glu 
                 85                  90                  95
Ile Leu Lys His Thr Val Asp Ile Glu Glu Lys Gly Val Lys Leu Lys 
             100                105                110
Leu Thr Ile Val Asp Thr Pro Gly Phe Gly Asp Ala Val Asn Asn Phe 
         115                120                125
Glu Cys Trp Lys Pro Ile Thr Asp Tyr Val Asp Gln Gln Phe Glu Gln 
     130                135                140
Tyr Phe Arg Asp Glu Ser Gly Leu Asn Arg Lys Asn Ile Gln Asp Asn 
 145                150                155                160
Arg Val His Cys Cys Leu Tyr Phe Ile Ser Pro Phe Gly His Gly Leu 
                 165                170                175
Arg Pro Val Asp Val Gly Phe Met Lys Ala Leu His Glu Lys Val Asn 
             180                185                190
Ile Val Pro Leu Ile Ala Lys Ala Asp Cys Leu Val Pro Ser Glu Ile 
         195                200                205
Arg Lys Leu Lys Asp Arg Ile Arg Glu Glu Ile Asp Lys Phe Gly Ile 
     210                215                220
His Val Tyr Gln Phe Pro Glu Cys Asp Ser Asp Glu Asp Glu Asp Phe 
 225                230                235                240
Lys Gln Gln Asp Arg Glu Leu Lys Glu Ser Ala Pro Phe Ala Val Ile 
                 245                250                255
Gly Ser Asn Thr Val Val Glu Ala Lys Gly Gln Arg Val Arg Gly Arg 
             260                265                270
Leu Tyr Pro Trp Gly Ile Val Glu Val Glu Asn Gln Ala His Cys Asp 
         275                280                285
Phe Val Lys Leu Arg Asn Met Leu Ile Arg Thr His Met His Asp Leu 
     290                295                300
Lys Asp Val Thr Cys Asp Val His Tyr Glu Asn Tyr Arg Ala His Cys 
 305                310                315                320
Ile Gln Gln Met Thr Ser Lys Leu Thr Gln Asp Ser Arg Met Glu Ser 
                 325                330                335
Pro Ile Pro Ile Leu Pro Leu Pro Thr Pro Asp Ser Glu Thr Glu Lys 
             340                345                350
Leu Ile Arg Met Lys Asp Glu Glu Leu Arg Arg Met Gln Glu Met Leu 
         355                360                365
Gln Lys Met Lys Gln Arg Met Gln Asp Gln 
     370                375



<210> 4567
<211> 1768
<212> DNA
<213> Homo sapiens
<308> AF035811
<400> 4567

ttggcctcg  ggccaagat  cggcacgag  aacagcatc  aaacaaggc  gtttctgtg  60
gtgaggaac  ttgcctggg  gataaaatt  gacctagag  tttctgaca  ggagtctga  120
gcgtgggac  tggaccgtt  actgggatg  caagggaat  ctgtccctg  ggacaggac  180
gaagctggg  tcaagcgtt  cctggagga  accacggat  atggagaac  gagcaagtt  240
gtgaaggat  tctcaggaa  tgcgagctg  cacccacca  aggctaaga  ctgggcatc  300
aggccccaa  tcccggagc  aaggcccca  gccccggac  tctatgatg  tgacctgga  360
ttcagaccc  cctcgcggc  ccagtcctc  gacaaccag  agtacttct  tgccccagc  420
cctctcagc  catctgcca  gccccgcag  ccatggggc  agcttgatc  ctatgattc  480
tctgaggat  acaaggagt  tgtgggctt  gcaaccctc  ccaaccaag  ccaccgaaa  540
tccgtgaag  aaggctttg  ctttaccct  atggtggca  gagagtctg  cctgggcaa  600
tccacactt  tcaatagcc  cttcctcac  gatctgtac  gggaccgga  acttcttgg  660
gctgaagag  ggatcatgc  aactgtgga  atcactaag  atgcagtgg  catagaaga  720
aagggtgtg  ggctgcggc  caccattgt  gacacacca  gttttgggg  tgcagtcaa  780
aacacagag  gctggaagc  tgtggcaga  tacattgat  agcagtttg  gcagtattt  840
cgagacgag  gtggcctga  ccgaaagaa  atccaagac  acagggtgc  ctgctgcct  900
tacttcatc  cacccttcg  ccatgggct  cggccattg  atgttgaat  catgaaggc  960
ctgcatcag  gggtcaaca  cgtgcctat  ctggctaag  cagacacac  gacacctcc  1020
gaagtggac  acaagaaac  caaaatccg  gaggagatt  agcattttg  aatcaagat  1080
tatcaattc  cagactgtg  ctctgatga  gatgaggac  tcaaattgc  ggaccaagc  1140
ctaaaggaa  gcatcccat  tgcagtaat  ggcagcaac  ctgtagtag  ggccagagg  1200
cgacgagtt  ggggtcgac  ctacccctg  ggcatcgtg  aagtggaaa  cccagggca  1260
tgcgacttt  tgaagctga  gacaatgct  gtacgtacc  acatgcagg  cctgaagga  1320
gtgacacgg  agacacatt  tgagaacta  cgggcacag  gcatccaga  catgacccg  1380
ctggtggtg  aggaacgga  tcgcaacaa  ctgactcgg  aaagtggta  cgacttccc  1440
atccctgct  tcccaccag  gacagatcc  gaaactgag  agcttatcc  agagaaaga  1500
gaggagctg  ggcggatgc  ggagatgct  cacaaaata  aaaaacaga  gaaggagaa  1560
tattaactg  ctttcagcc  tggatattt  aatctcctc  tcttcttcc  gtccatgcc  1620
gcccctccc  gcaccagtt  tgctcaggc  ccttcagct  ctgccactt  gccttacat  1680
cctgctgac  gcccagaga  tcagaggaa  taaagttta  taaatctgt  ggtggctaa  1740
aaaaaaaaa  aaaaaaaaa  aaaaaaaa  1768



<210> 4568
<211> 478
<212> PRT
<213> Homo sapiens
<308> O43236
<400> 4568

Met Asp Arg Ser Leu Gly Trp Gln Gly Asn Ser Val Pro Glu Asp Arg 
  1               5                  10                  15
Thr Glu Ala Gly Ile Lys Arg Phe Leu Glu Asp Thr Thr Asp Asp Gly 
             20                  25                  30
Glu Leu Ser Lys Phe Val Lys Asp Phe Ser Gly Asn Ala Ser Cys His 
         35                  40                  45
Pro Pro Glu Ala Lys Thr Trp Ala Ser Arg Pro Gln Val Pro Glu Pro 
     50                  55                  60
Arg Pro Gln Ala Pro Asp Leu Tyr Asp Asp Asp Leu Glu Phe Arg Pro 
 65                  70                  75                  80
Pro Ser Arg Pro Gln Ser Ser Asp Asn Gln Gln Tyr Phe Cys Ala Pro 
                 85                  90                  95
Ala Pro Leu Ser Pro Ser Ala Arg Pro Arg Ser Pro Trp Gly Lys Leu 
             100                105                110
Asp Pro Tyr Asp Ser Ser Glu Asp Asp Lys Glu Tyr Val Gly Phe Ala 
         115                120                125
Thr Leu Pro Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp 
     130                135                140
Phe Thr Leu Met Val Ala Gly Glu Ser Gly Leu Gly Lys Ser Thr Leu 
 145                150                155                160
Val Asn Ser Leu Phe Leu Thr Asp Leu Tyr Arg Asp Arg Lys Leu Leu 
                 165                170                175
Gly Ala Glu Glu Arg Ile Met Gln Thr Val Glu Ile Thr Lys His Ala 
             180                185                190
Val Asp Ile Glu Glu Lys Gly Val Arg Leu Arg Leu Thr Ile Val Asp 
         195                200                205
Thr Pro Gly Phe Gly Asp Ala Val Asn Asn Thr Glu Cys Trp Lys Pro 
     210                215                220
Val Ala Glu Tyr Ile Asp Gln Gln Phe Glu Gln Tyr Phe Arg Asp Glu 
 225                230                235                240
Ser Gly Leu Asn Arg Lys Asn Ile Gln Asp Asn Arg Val His Cys Cys 
                 245                250                255
Leu Tyr Phe Ile Ser Pro Phe Gly His Gly Leu Arg Pro Leu Asp Val 
             260                265                270
Glu Phe Met Lys Ala Leu His Gln Arg Val Asn Ile Val Pro Ile Leu 
         275                280                285
Ala Lys Ala Asp Thr Leu Thr Pro Pro Glu Val Asp His Lys Lys Arg 
     290                295                300
Lys Ile Arg Glu Glu Ile Glu His Phe Gly Ile Lys Ile Tyr Gln Phe 
 305                310                315                320
Pro Asp Cys Asp Ser Asp Glu Asp Glu Asp Phe Lys Leu Gln Asp Gln 
                 325                330                335
Ala Leu Lys Glu Ser Ile Pro Phe Ala Val Ile Gly Ser Asn Thr Val 
             340                345                350
Val Glu Ala Arg Gly Arg Arg Val Arg Gly Arg Leu Tyr Pro Trp Gly 
         355                360                365
Ile Val Glu Val Glu Asn Pro Gly His Cys Asp Phe Val Lys Leu Arg 
     370                375                380
Thr Met Leu Val Arg Thr His Met Gln Asp Leu Lys Asp Val Thr Arg 
 385                390                395                400
Glu Thr His Tyr Glu Asn Tyr Arg Ala Gln Cys Ile Gln Ser Met Thr 
                 405                410                415
Arg Leu Val Val Lys Glu Arg Asn Arg Asn Lys Leu Thr Arg Glu Ser 
             420                425                430
Gly Thr Asp Phe Pro Ile Pro Ala Val Pro Pro Gly Thr Asp Pro Glu 
         435                440                445
Thr Glu Lys Leu Ile Arg Glu Lys Asp Glu Glu Leu Arg Arg Met Gln 
     450                455                460
Glu Met Leu His Lys Ile Gln Lys Gln Met Lys Glu Asn Tyr 
 465                470                475



<210> 4569
<211> 579
<212> DNA
<213> Rattus norvegicus
<308> AA800024
<400> 4569

aggtttgca  gtgcctcta  tagccagaa  atggcgcta  aggtatgag  gatctgacc  60
acaccgtgg  tgctgagaa  tgagctact  aatcctttt  caatggcag  acacgctta  120
gcagagcca  ctctccagc  cctagatct  actttaact  tgtttgtgc  tgtgcctgc  180
cagtgagca  acaggtccc  cagaggtcc  tggagcacc  ggagctgaa  ttcaaagca  240
ttgtgagac  ttcatgggt  ctgggaact  aagtccatt  cccctcgaa  agcagtgtc  300
gtttaacca  tgagcaggc  ctccagcat  ctgaactta  attttgttg  aatagggtc  360
cactgtgta  ccctaactg  cttggaact  tgttgatta  gttggcctt  aagattcgc  420
tccctatgc  cccgagtgc  gggattacg  ggaaatgca  acactcggc  tgaattttc  480
tcagtggag  ttaaaggga  tggcggtta  aactgggaa  acctttagg  aactaagcc  540
cgtagacaa  cttggcttc  aatgtccgc  caaggggac  579



<210> 4570
<211> 1472
<212> PRT
<213> Rattus norvegicus
<308> NP_033860
<400> 4570

Met Val Ala Val Ala Ala Ala Ala Ala Thr Glu Ala Arg Leu Arg Gly 
  1               5                  10                  15
Ser Thr Thr Thr Thr Ala Ala Pro Ala Gly Arg Lys Gly Arg Gln His 
             20                  25                  30
Arg Pro Cys Thr Ala Thr Gly Ala Trp Arg Pro Gly Pro Arg Ala Arg 
         35                  40                  45
Leu Cys Leu Pro Arg Val Leu Ser Arg Ala Leu Pro Pro Pro Pro Leu 
     50                  55                  60
Leu Pro Leu Leu Phe Ser Leu Leu Leu Leu Pro Leu Pro Arg Glu Ala 
 65                  70                  75                  80
Glu Ala Ala Ala Val Ala Ala Ala Val Ser Gly Ser Ala Ala Ala Glu 
                 85                  90                  95
Ala Lys Glu Cys Asp Arg Pro Cys Val Asn Gly Gly Arg Cys Asn Pro 
             100                105                110
Gly Thr Gly Gln Cys Val Cys Pro Thr Gly Trp Val Gly Glu Gln Cys 
         115                120                125
Gln His Cys Gly Gly Arg Phe Arg Leu Thr Gly Ser Ser Gly Phe Val 
     130                135                140
Thr Asp Gly Pro Gly Asn Tyr Lys Tyr Lys Thr Lys Cys Thr Trp Leu 
 145                150                155                160
Ile Glu Gly Gln Pro Asn Arg Ile Met Arg Leu Arg Phe Asn His Phe 
                 165                170                175
Ala Thr Glu Cys Ser Trp Asp His Leu Tyr Val Tyr Asp Gly Asp Ser 
             180                185                190
Ile Tyr Ala Pro Leu Ile Ala Ala Phe Ser Gly Leu Ile Val Pro Glu 
         195                200                205
Arg Asp Gly Asn Glu Thr Ala Pro Glu Val Thr Val Thr Ser Gly Tyr 
     210                215                220
Ala Leu Leu His Phe Phe Ser Asp Ala Ala Tyr Asn Leu Thr Gly Phe 
 225                230                235                240
Asn Ile Thr Tyr Asn Phe Asp Met Cys Pro Asn Asn Cys Ser Gly Arg 
                 245                250                255
Gly Glu Cys Lys Ser Ser Asn Ser Ser Ser Ala Val Glu Cys Glu Cys 
             260                265                270
Ser Glu Asn Trp Lys Gly Glu Ser Cys Asp Ile Pro His Cys Thr Asp 
         275                280                285
Asn Cys Gly Phe Pro His Arg Gly Ile Cys Asn Ala Ser Asp Thr Arg 
     290                295                300
Gly Cys Ser Cys Phe Pro His Trp Gln Gly Pro Gly Cys Ser Ile Pro 
 305                310                315                320
Val Pro Ala Asn Gln Ser Phe Trp Thr Arg Glu Glu Tyr Ser Asp Leu 
                 325                330                335
Lys Leu Pro Arg Ala Ser His Lys Ala Val Val Asn Gly Asn Ile Met 
             340                345                350
Trp Val Val Gly Gly Tyr Met Phe Asn His Ser Asp Tyr Ser Met Val 
         355                360                365
Leu Ala Tyr Asp Leu Thr Ser Arg Glu Trp Leu Pro Leu Asn His Ser 
     370                375                380
Val Asn Ser Val Val Val Arg Tyr Gly His Ser Leu Ala Leu His Lys 
 385                390                395                400
Asp Lys Ile Tyr Met Tyr Gly Gly Lys Ile Asp Ser Thr Gly Asn Val 
                 405                410                415
Thr Asn Glu Leu Arg Val Phe His Ile His Asn Glu Ser Trp Val Leu 
             420                425                430
Leu Thr Pro Lys Ala Lys Asp Gln Tyr Ala Val Val Gly His Ser Ala 
         435                440                445
His Ile Val Thr Leu Ala Ser Gly Arg Val Val Met Leu Val Ile Phe 
     450                455                460
Gly His Cys Pro Leu Tyr Gly Tyr Ile Ser Val Val Gln Glu Tyr Asp 
 465                470                475                480
Leu Glu Lys Asn Thr Trp Ser Ile Leu His Thr Gln Gly Ala Leu Val 
                 485                490                495
Gln Gly Gly Tyr Gly His Ser Ser Val Tyr Asp Asp Arg Thr Lys Ala 
             500                505                510
Leu Tyr Val His Gly Gly Tyr Lys Ala Phe Ser Ala Asn Lys Tyr Arg 
         515                520                525
Leu Ala Asp Asp Leu Tyr Arg Tyr Asp Val Asp Thr Gln Met Trp Thr 
     530                535                540
Ile Leu Lys Asp Ser Arg Phe Phe Arg Tyr Leu His Thr Ala Val Ile 
 545                550                555                560
Val Ser Gly Thr Met Leu Val Phe Gly Gly Asn Thr His Asn Asp Thr 
                 565                570                575
Ser Met Ser His Gly Ala Lys Cys Phe Ser Ser Asp Phe Met Ala Tyr 
             580                585                590
Asp Ile Ala Cys Asp Arg Trp Ser Val Leu Pro Arg Pro Glu Leu His 
         595                600                605
His Asp Val Asn Arg Phe Gly His Ser Ala Val Leu Tyr Asn Ser Thr 
     610                615                620
Met Tyr Val Phe Gly Gly Phe Asn Ser Leu Leu Leu Ser Asp Val Leu 
 625                630                635                640
Val Phe Thr Ser Glu Gln Cys Asp Ala His Arg Ser Glu Ala Ala Cys 
                 645                650                655
Val Ala Ala Gly Pro Gly Ile Arg Cys Leu Trp Asp Thr Gln Ser Ser 
             660                665                670
Arg Cys Thr Ser Trp Glu Leu Ala Thr Glu Glu Gln Ala Glu Lys Leu 
         675                680                685
Lys Ser Glu Cys Phe Ser Lys Arg Thr Leu Asp His Asp Arg Cys Asp 
     690                695                700
Gln His Thr Asp Cys Tyr Ser Cys Thr Ala Asn Thr Asn Asp Cys His 
 705                710                715                720
Trp Cys Asn Asp His Cys Val Pro Val Asn His Ser Cys Thr Glu Gly 
                 725                730                735
Gln Ile Ser Ile Ala Lys Tyr Glu Ser Cys Pro Lys Asp Asn Pro Met 
             740                745                750
Tyr Tyr Cys Asn Lys Lys Thr Ser Cys Arg Ser Cys Ala Leu Asp Gln 
         755                760                765
Asn Cys Gln Trp Glu Pro Arg Asn Gln Glu Cys Ile Ala Leu Pro Glu 
     770                775                780
Asn Ile Cys Gly Asn Gly Trp His Leu Val Gly Asn Ser Cys Leu Lys 
 785                790                795                800
Ile Thr Thr Ala Lys Glu Asn Tyr Asp Asn Ala Lys Leu Ser Cys Arg 
                 805                810                815
Asn His Asn Ala Phe Leu Ala Ser Leu Thr Ser Gln Lys Lys Val Glu 
             820                825                830
Phe Val Leu Lys Gln Leu Arg Leu Met Gln Ser Ser Gln Ser Met Ser 
         835                840                845
Lys Leu Thr Leu Thr Pro Trp Val Gly Leu Arg Lys Ile Asn Val Ser 
     850                855                860
Tyr Trp Cys Trp Glu Asp Met Ser Pro Phe Thr Asn Ser Leu Leu Gln 
 865                870                875                880
Trp Met Pro Ser Glu Pro Ser Asp Ala Gly Phe Cys Gly Ile Leu Ser 
                 885                890                895
Glu Pro Ser Thr Arg Gly Leu Lys Ala Ala Thr Cys Ile Asn Pro Leu 
             900                905                910
Asn Gly Ser Val Cys Glu Arg Pro Ala Asn His Ser Ala Lys Gln Cys 
         915                920                925
Arg Thr Pro Cys Ala Leu Arg Thr Ala Cys Gly Glu Cys Thr Ser Ser 
     930                935                940
Ser Ser Glu Cys Met Trp Cys Ser Asn Met Lys Gln Cys Val Asp Ser 
 945                950                955                960
Asn Ala Tyr Val Ala Ser Phe Pro Phe Gly Gln Cys Met Glu Trp Tyr 
                 965                970                975
Thr Met Ser Ser Cys Pro Pro Glu Asn Cys Ser Gly Tyr Cys Thr Cys 
             980                985                990
Ser His Cys Leu Glu Gln Pro Gly Cys Gly Trp Cys Thr Asp Pro Ser 
         995                1000                1005
Asn Thr Gly Lys Gly Lys Cys Ile Glu Gly Ser Tyr Lys Gly Pro Val 
     1010                1015                1020
Lys Met Pro Ser Gln Ala Ser Ala Gly Asn Val Tyr Pro Gln Pro Leu 
 1025                1030                1035                1040
Leu Asn Ser Ser Met Cys Leu Glu Asp Ser Arg Tyr Asn Trp Ser Phe 
                 1045                1050                1055
Ile His Cys Pro Ala Cys Gln Cys Asn Gly His Ser Lys Cys Ile Asn 
             1060                1065                1070
Gln Ser Ile Cys Glu Lys Cys Glu Asp Leu Thr Thr Gly Lys His Cys 
         1075                1080                1085
Glu Thr Cys Ile Ser Gly Phe Tyr Gly Asp Pro Thr Asn Gly Gly Lys 
     1090                1095                1100
Cys Gln Pro Cys Lys Cys Asn Gly His Ala Ser Leu Cys Asn Thr Asn 
 1105                1110                1115                1120
Thr Gly Lys Cys Phe Cys Thr Thr Lys Gly Val Lys Gly Asp Glu Cys 
                 1125                1130                1135
Gln Leu Cys Glu Val Glu Asn Arg Tyr Gln Gly Asn Pro Leu Lys Gly 
             1140                1145                1150
Thr Cys Tyr Tyr Thr Leu Leu Ile Asp Tyr Gln Phe Thr Phe Ser Leu 
         1155                1160                1165
Ser Gln Glu Asp Asp Arg Tyr Tyr Thr Ala Ile Asn Phe Val Ala Thr 
     1170                1175                1180
Pro Asp Glu Gln Asn Arg Asp Leu Asp Met Phe Ile Asn Ala Ser Lys 
 1185                1190                1195                1200
Asn Phe Asn Leu Asn Ile Thr Trp Ala Thr Ser Phe Pro Ala Gly Thr 
                 1205                1210                1215
Gln Thr Gly Glu Glu Val Pro Val Val Ser Lys Thr Asn Ile Lys Glu 
             1220                1225                1230
Tyr Lys Asp Ser Phe Ser Asn Glu Lys Phe Asp Phe Arg Asn His Pro 
         1235                1240                1245
Asn Ile Thr Phe Phe Val Tyr Val Ser Asn Phe Thr Trp Pro Ile Lys 
     1250                1255                1260
Ile Gln Ile Ala Phe Ser Gln His Ser Asn Phe Met Asp Leu Val Gln 
 1265                1270                1275                1280
Phe Phe Val Thr Phe Phe Ser Cys Phe Leu Ser Leu Leu Leu Val Ala 
                 1285                1290                1295
Ala Val Val Trp Lys Ile Lys Gln Ser Cys Trp Ala Ser Arg Arg Arg 
             1300                1305                1310
Glu Gln Leu Leu Arg Glu Met Gln Gln Met Ala Ser Arg Pro Phe Ala 
         1315                1320                1325
Ser Val Asn Val Ala Leu Glu Thr Asp Glu Glu Pro Pro Asp Leu Ile 
     1330                1335                1340
Gly Gly Ser Ile Lys Thr Val Pro Lys Pro Ile Ala Leu Glu Pro Cys 
 1345                1350                1355                1360
Phe Gly Asn Lys Ala Ala Val Leu Ser Val Phe Val Arg Leu Pro Arg 
                 1365                1370                1375
Gly Leu Gly Gly Ile Pro Pro Pro Gly Gln Ser Arg Ser Arg Cys Gly 
             1380                1385                1390
Gln Cys Pro Gly Gly His Phe Ser Ala Asp Ala Asn Ser Val Gln Gly 
         1395                1400                1405
Glu Val Arg Ser Cys Lys Lys Pro Glu Ala Ala Ala Ala Cys Thr Ala 
     1410                1415                1420
Trp Asn Leu His Leu Ile Leu Gly Gln Glu Phe Ala Leu Thr Glu Gly 
 1425                1430                1435                1440
Val Trp Ser Thr Lys Leu Ser Thr Gly Glu Ala Ala Gly Arg Lys Gln 
                 1445                1450                1455
Ala Trp Gly Arg Arg Leu Gly Thr Leu Glu Ala Ser Asn Ser Cys Ala 
             1460                1465                1470



<210> 4571
<211> 1723
<212> DNA
<213> Homo sapiens
<308> AK021433
<400> 4571

ctcgaccct  gacgtctac  ttccggagg  ccacatctt  cccactccg  gcgcggggc  60
agcgcgggt  tcagcgacg  gagccctca  gggacatgg  aactacagc  gcgccggcg  120
gcggcgccc  aaatggagc  ggcccggaa  ggggagggt  cgaagaaaa  atccagggc  180
gaggctcag  tgtgattga  atggagaac  tggatgata  ctcaggctc  agcttcgag  240
atatgggtg  gctgcatca  cgcctgcgc  aggaagaag  agacgctga  gcagctgat  300
cagctgctg  tgaagagga  gatggagag  tcctgggca  gaagggctt  aagggacag  360
tgagccggc  ggtggcaga  cagatgtgg  aggctggga  aagacaagc  tccagggcc  420
tcagcttgt  cgccaacat  gacatcctc  gaccctact  tgatgtgga  cctgctcag  480
tgcgaagca  gctcctgga  tccatgatc  ctatcaaga  ggtcaactt  ccccagaaa  540
ttgcaggtg  actctatgg  cctctcatg  tggtcttca  tctggttgc  atcctactc  600
atgggatga  gacgtctga  actattatc  gggagggca  cctgatggg  acagccatt  660
gcacctgct  cggctactg  ctgggagtc  catccttca  ttacttcct  gcctacctg  720
gcaacgccc  gatcaccat  ctgcagatg  tggcactgc  gggctatgg  ctctttggg  780
gttgcattg  cctgttcat  acctataat  tccacctcc  cgccctctt  tacctcttc  840
ggctgttgg  gggtggact  tccacactg  gcatggtag  agtgttggt  tctcggacc  900
tgggcccca  atcttgccc  ctccgcgcg  ggggctagc  cgggtttca  cgacgggag  960
cctcaaggg  catggcaac  acagcggcg  cggcgggcg  cgcccgaaa  ggagctggc  1020
cggaatggg  agggttcga  gaaaacatc  agggcggag  ctcagctgt  attgacatg  1080
agaacatgg  tgatacctc  ggctctagc  tcgaggata  gggtgagct  catcagcgc  1140
tgcgcgagg  agaagtaga  gctgatgca  ctgatgcag  tgctgctga  gaggaggat  1200
gagagcacc  tggctgccc  acacatgct  ttcctgctc  atctgcatt  tgcctacca  1260
aaagtggta  aggggatcc  ggacacact  gagggcccc  acatcccgc  catccagag  1320
gtccccaga  acatccctg  catgctccc  gctgctcgg  ttcccacca  cgtcctcaa  1380
gccacagcc  aagctgttg  ggtgaccct  cagtcctct  tcccgcagc  gcagagagg  1440
ggaagacta  taaaggaca  tcctgatga  atgtttcgt  gatggggtt  gcagctgcc  1500
ctgagctgt  gctgcgtaa  tacctcctt  atgcctgtc  gcacttctg  aaggcacaa  1560
gccaagaac  cctggccag  actgcaagg  tctgcagcc  atgcagaaa  tgggtcagc  1620
cctttgaga  cccctcccc  cctacccct  ccttcctct  tatctctcc  acattgtct  1680
gctaaatat  gacttggta  ttaaaatgt  gattgaagt  tgg  1723



<210> 4572
<211> 1198
<212> PRT
<213> Homo sapiens
<308> NP_036202
<400> 4572

Met Val Ala Ala Ala Ala Ala Thr Glu Ala Arg Leu Arg Arg Arg Thr 
  1               5                  10                  15
Ala Ala Thr Ala Ala Leu Ala Gly Arg Ser Gly Gly Pro His Cys Val 
             20                  25                  30
Asn Gly Gly Arg Cys Asn Pro Gly Thr Gly Gln Cys Val Cys Pro Ala 
         35                  40                  45
Gly Trp Val Gly Glu Gln Cys Gln His Cys Gly Gly Arg Phe Arg Leu 
     50                  55                  60
Thr Gly Ser Ser Gly Phe Val Thr Asp Gly Pro Gly Asn Tyr Lys Tyr 
 65                  70                  75                  80
Lys Thr Lys Cys Thr Trp Leu Ile Glu Gly Gln Pro Asn Arg Ile Met 
                 85                  90                  95
Arg Leu Arg Phe Asn His Phe Ala Thr Glu Cys Ser Trp Asp His Leu 
             100                105                110
Tyr Val Tyr Asp Gly Asp Ser Ile Tyr Ala Pro Leu Val Ala Ala Phe 
         115                120                125
Ser Gly Leu Ile Val Pro Glu Arg Asp Gly Asn Glu Thr Val Pro Glu 
     130                135                140
Val Val Ala Thr Ser Gly Tyr Ala Leu Leu His Phe Phe Ser Asp Ala 
 145                150                155                160
Ala Tyr Asn Leu Thr Gly Phe Asn Ile Thr Tyr Ser Phe Asp Met Cys 
                 165                170                175
Pro Asn Asn Cys Ser Gly Arg Gly Glu Cys Lys Ile Ser Asn Ser Ser 
             180                185                190
Asp Thr Val Glu Cys Glu Cys Ser Glu Asn Trp Lys Gly Glu Ala Cys 
         195                200                205
Asp Ile Pro His Cys Thr Asp Asn Cys Gly Phe Pro His Arg Gly Ile 
     210                215                220
Cys Asn Ser Ser Asp Val Arg Gly Cys Ser Cys Phe Ser Asp Trp Gln 
 225                230                235                240
Gly Pro Gly Cys Ser Val Pro Val Pro Ala Asn Gln Ser Phe Trp Thr 
                 245                250                255
Arg Glu Glu Tyr Ser Asn Leu Lys Leu Pro Arg Ala Ser His Lys Ala 
             260                265                270
Val Val Asn Gly Asn Ile Met Trp Val Val Gly Gly Tyr Met Phe Asn 
         275                280                285
His Ser Asp Tyr Asn Met Val Leu Ala Tyr Asp Leu Ala Ser Arg Glu 
     290                295                300
Trp Leu Pro Leu Asn Arg Ser Val Asn Asn Val Val Val Arg Tyr Gly 
 305                310                315                320
His Ser Leu Ala Leu Tyr Lys Asp Lys Ile Tyr Met Tyr Gly Gly Lys 
                 325                330                335
Ile Asp Ser Thr Gly Asn Val Thr Asn Glu Leu Arg Val Phe His Ile 
             340                345                350
His Asn Glu Ser Trp Val Leu Leu Thr Pro Lys Ala Lys Glu Gln Tyr 
         355                360                365
Ala Val Val Gly His Ser Ala His Ile Val Thr Leu Lys Asn Gly Arg 
     370                375                380
Val Val Met Leu Val Ile Phe Gly His Cys Pro Leu Tyr Gly Tyr Ile 
 385                390                395                400
Ser Asn Val Gln Glu Tyr Asp Leu Asp Lys Asn Thr Trp Ser Ile Leu 
                 405                410                415
His Thr Gln Gly Ala Leu Val Gln Gly Gly Tyr Gly His Ser Ser Val 
             420                425                430
Tyr Asp His Arg Thr Arg Ala Leu Tyr Val His Gly Gly Tyr Lys Ala 
         435                440                445
Phe Ser Ala Asn Lys Tyr Arg Leu Ala Asp Asp Leu Tyr Arg Tyr Asp 
     450                455                460
Val Asp Thr Gln Met Trp Thr Ile Leu Lys Asp Ser Arg Phe Phe Arg 
 465                470                475                480
Tyr Leu His Thr Ala Val Ile Val Ser Gly Thr Met Leu Val Phe Gly 
                 485                490                495
Gly Asn Thr His Asn Asp Thr Ser Met Ser His Gly Ala Lys Cys Phe 
             500                505                510
Ser Ser Asp Phe Met Ala Tyr Asp Ile Ala Cys Asp Arg Trp Ser Val 
         515                520                525
Leu Pro Arg Pro Asp Leu His His Asp Val Asn Arg Phe Gly His Ser 
     530                535                540
Ala Val Leu His Asn Ser Thr Met Tyr Val Phe Gly Gly Phe Asn Ser 
 545                550                555                560
Leu Leu Leu Ser Asp Ile Leu Val Phe Thr Ser Glu Gln Cys Asp Ala 
                 565                570                575
His Arg Ser Glu Ala Ala Cys Leu Ala Ala Gly Pro Gly Ile Arg Cys 
             580                585                590
Val Trp Asn Thr Gly Ser Ser Gln Cys Ile Ser Trp Ala Leu Ala Thr 
         595                600                605
Asp Glu Gln Glu Glu Lys Leu Lys Ser Glu Cys Phe Ser Lys Arg Thr 
     610                615                620
Leu Asp His Asp Arg Cys Asp Gln His Thr Asp Cys Tyr Ser Cys Thr 
 625                630                635                640
Ala Asn Thr Asn Asp Cys His Trp Cys Asn Asp His Cys Val Pro Arg 
                 645                650                655
Asn His Ser Cys Ser Glu Gly Gln Ile Ser Ile Phe Arg Tyr Glu Asn 
             660                665                670
Cys Pro Lys Asp Asn Pro Met Tyr Tyr Cys Asn Lys Lys Thr Ser Cys 
         675                680                685
Arg Ser Cys Ala Leu Asp Gln Asn Cys Gln Trp Glu Pro Arg Asn Gln 
     690                695                700
Glu Cys Ile Ala Leu Pro Glu Asn Ile Cys Gly Ile Gly Trp His Leu 
 705                710                715                720
Val Gly Asn Ser Cys Leu Lys Ile Thr Thr Ala Lys Glu Asn Tyr Asp 
                 725                730                735
Asn Ala Lys Leu Phe Cys Arg Asn His Asn Ala Leu Leu Ala Ser Leu 
             740                745                750
Thr Thr Gln Lys Lys Val Glu Phe Val Leu Lys Gln Leu Arg Ile Met 
         755                760                765
Gln Ser Ser Gln Ser Met Ser Lys Leu Thr Leu Thr Pro Trp Val Gly 
     770                775                780
Leu Arg Lys Ile Asn Val Ser Tyr Trp Cys Trp Glu Asp Met Ser Pro 
 785                790                795                800
Phe Thr Asn Ser Leu Leu Gln Trp Met Pro Ser Glu Pro Ser Asp Ala 
                 805                810                815
Gly Phe Cys Gly Ile Leu Ser Glu Pro Ser Thr Arg Gly Leu Lys Ala 
             820                825                830
Ala Thr Cys Ile Asn Pro Leu Asn Gly Ser Val Cys Glu Arg Pro Ala 
         835                840                845
Asn His Ser Ala Lys Gln Cys Arg Thr Pro Cys Ala Leu Arg Thr Ala 
     850                855                860
Cys Gly Asp Cys Thr Ser Gly Ser Ser Glu Cys Met Trp Cys Ser Asn 
 865                870                875                880
Met Lys Gln Cys Val Asp Ser Asn Ala Tyr Val Ala Ser Phe Pro Phe 
                 885                890                895
Gly Gln Cys Met Glu Trp Tyr Thr Met Ser Thr Cys Pro Pro Glu Asn 
             900                905                910
Cys Ser Gly Tyr Cys Thr Cys Ser His Cys Leu Glu Gln Pro Gly Cys 
         915                920                925
Gly Trp Cys Thr Asp Pro Ser Asn Thr Gly Lys Gly Lys Cys Ile Glu 
     930                935                940
Gly Ser Tyr Lys Gly Pro Val Lys Met Pro Ser Gln Ala Pro Thr Gly 
 945                950                955                960
Asn Phe Tyr Pro Gln Pro Leu Leu Asn Ser Ser Met Cys Leu Glu Asp 
                 965                970                975
Ser Arg Tyr Asn Trp Ser Phe Ile His Cys Pro Ala Cys Gln Cys Asn 
             980                985                990
Gly His Ser Lys Cys Ile Asn Gln Ser Ile Cys Glu Lys Cys Glu Asn 
         995                1000                1005
Leu Thr Thr Gly Lys His Cys Glu Thr Cys Ile Ser Gly Phe Tyr Gly 
     1010                1015                1020
Asp Pro Thr Asn Gly Gly Lys Cys Gln Pro Cys Lys Cys Asn Gly His 
 1025                1030                1035                1040
Ala Ser Leu Cys Asn Thr Asn Thr Gly Lys Cys Phe Cys Thr Thr Lys 
                 1045                1050                1055
Gly Val Lys Gly Asp Glu Cys Gln Leu Cys Glu Val Glu Asn Arg Tyr 
             1060                1065                1070
Gln Gly Asn Pro Leu Arg Gly Thr Cys Tyr Tyr Thr Leu Leu Ile Asp 
         1075                1080                1085
Tyr Gln Phe Thr Phe Ser Leu Ser Gln Glu Asp Asp Arg Tyr Tyr Thr 
     1090                1095                1100
Ala Ile Asn Phe Val Ala Thr Pro Asp Glu Gln Asn Arg Asp Leu Asp 
 1105                1110                1115                1120
Met Phe Ile Asn Ala Ser Lys Asn Phe Asn Leu Asn Ile Thr Trp Ala 
                 1125                1130                1135
Ala Ser Phe Ser Ala Gly Thr Gln Ala Gly Glu Glu Met Pro Val Val 
             1140                1145                1150
Ser Lys Thr Asn Ile Lys Glu Tyr Lys Asp Ser Phe Ser Asn Glu Lys 
         1155                1160                1165
Phe Asp Phe Arg Asn His Pro Asn Ile Thr Phe Phe Val Tyr Val Ser 
     1170                1175                1180
Asn Phe Thr Trp Pro Ile Lys Ile Gln Val Gln Thr Glu Gln 
 1185                1190                1195



<210> 4573
<211> 613
<212> DNA
<213> Rattus norvegicus
<308> AA800034
<400> 4573

aaaaacaaa  tttaatcat  cttattaat  acaagactt  atataaaaa  gcagagtat  60
aattcaact  ccattattt  agttaactt  caattatcc  ttccaaatt  aaacaaaat  120
ccaaacagg  caaattgta  atttaaatc  aagactatt  agttacaaa  ggagtaaat  180
acaaaataa  aatgcttaa  attaagaat  tacctatca  ataagagaa  aaacagaag  240
gtgtgcatt  tgaatgtcc  attttacca  catgatgta  ggggtcctt  tatgtacaa  300
ctctgccac  ggatcactg  tatgtctca  tgaacttcg  aatcctatg  gcaacatgt  360
caaggtgga  aagagggtc  acacttagc  tacaggact  acacactga  tccttaagg  420
agttgatga  acggctaca  acttcacac  gagaaatgt  tttggtagc  cagagagag  480
taaacattt  gagagttaa  aacaaagac  gtcagtcat  gggaaacat  caaggacaa  540
gagaactgc  taatcactc  cacaacaaa  tttattact  attaaaatt  aaatttgag  600
tgggaccct  gtt  613



<210> 4574
<211> 613
<212> DNA
<213> Rattus norvegicus
<308> AA800034
<400> 4574

aaaaacaaa  tttaatcat  cttattaat  acaagactt  atataaaaa  gcagagtat  60
aattcaact  ccattattt  agttaactt  caattatcc  ttccaaatt  aaacaaaat  120
ccaaacagg  caaattgta  atttaaatc  aagactatt  agttacaaa  ggagtaaat  180
acaaaataa  aatgcttaa  attaagaat  tacctatca  ataagagaa  aaacagaag  240
gtgtgcatt  tgaatgtcc  attttacca  catgatgta  ggggtcctt  tatgtacaa  300
ctctgccac  ggatcactg  tatgtctca  tgaacttcg  aatcctatg  gcaacatgt  360
caaggtgga  aagagggtc  acacttagc  tacaggact  acacactga  tccttaagg  420
agttgatga  acggctaca  acttcacac  gagaaatgt  tttggtagc  cagagagag  480
taaacattt  gagagttaa  aacaaagac  gtcagtcat  gggaaacat  caaggacaa  540
gagaactgc  taatcactc  cacaacaaa  tttattact  attaaaatt  aaatttgag  600
tgggaccct  gtt  613



<210> 4575
<211> 514
<212> DNA
<213> Rattus norvegicus
<308> AA800036
<400> 4575

acataaaac  ttcaaggaa  catgtggat  cgacagaat  ttaatagca  atctaagaa  60
aaacctcag  tagtcaaca  tcacaaaat  ttgaaaact  attaaaata  acgtagtat  120
gagagctac  acttcacta  gaggcaggc  tgtattttg  cttgttagc  ccgtcattt  180
cagttcctc  tcaaagcta  agtgaagaa  gaaatggtc  atggtaaaa  actgctcca  240
cttaaagtt  agctaaaca  ataaaaata  agttaaaac  accctctgc  tatccacgg  300
tgttggtgg  gtaagtact  tacagttct  gtaacgata  tttattaaa  ggcctgata  360
taagtggag  gagtaaaaa  aaaaagaat  aaattaaaa  aaattaaga  gcgaaagca  420
tcacgggac  agaacgtgg  cattacaat  actaacacg  tgtctcttt  ngagccact  480
tagcacaga  tttttacga  acagagcag  taat  514



<210> 4576
<211> 2112
<212> DNA
<213> Homo sapiens
<308> NM_014575
<400> 4576

cggctttca  agccaattt  aataaacaa  tcttccctc  caaatgggc  agagtaact  60
ttcagcacc  tggagaggt  cgggcagcg  gttacaacg  gggactgtg  ccagggcaa  120
cactctgac  gtgattacc  agaggatgg  atggatcta  gcagtgacg  cggcagcag  180
agcagcagc  gccgcgcca  ttcacagtc  aactccacc  aagtgaccc  ttgctccga  240
tgcaaatct  catcgtcgc  ggggggcag  ctggacttg  tgtctgccc  ggaggacta  300
gaggagccc  tcccggtct  ccagaagaa  gtgattgat  agtgggcgc  ggaggagga  360
ggggaggag  aggaagagg  ggacgagcg  gaccagcga  ggtaccggg  tgaccgctc  420
ccggcccgg  aaccggggg  cgtaagcgc  aggacccgc  gcggcggcg  cgggggcag  480
agcgccacc  ccgccatgc  gcccccggt  cccaacggc  acctccacc  gcacgaccc  540
caggacctc  ggcacaatg  caacgtggt  gtggctggc  ggccgagct  ttcccgggg  600
ccccgccgg  cgatccaaa  gccccagcc  gctgggggc  ggcgcagtg  ccgcggccc  660
gcggctggg  ggctctgcc  tcagccccc  gacggcggg  cgtgcgtcc  cgaagagcc  720
ccggtgcca  ctatggatt  ggaggcgct  gagaagcat  tggccgggc  gcagttccg  780
gagcaggag  tacggaacc  gggccaggc  aggaccaac  ccacctccg  acagaaaaa  840
gagagagag  ctatcagac  gaagttggc  cttggaagc  tctttgatg  tggcccagg  900
atttatacc  gctgtagca  aagtgggaa  ccaagcctt  cctcccgac  gcagagtgg  960
atgaacttg  agatatgct  tgtcaacga  agtggcagt  ataaggaca  tgatgctga  1020
gacagtaag  ctgaaacca  cttggacac  cccttgtct  ccatgagca  acagagttc  1080
tcctattct  atagagaca  tactgaaga  gagtctgaa  ccttggatg  catggactt  1140
cttacaagg  aaaagaaat  gcaagctga  gccaaaatg  cccttgcca  ggccaaacc  1200
atggccaaa  tgcaagtag  agtggagaa  cagaacagg  aaaagtctc  cgtcgctga  1260
cttctgcca  acatgcctc  tataagtga  tgcttgatg  aaagaagtt  aaaacccac  1320
gacctgaga  acatgacta  tgggcagct  caagtgata  tcaatgatc  ccattccca  1380
atagaaagc  tgaatgaag  gttggtcca  ctgcttctc  tccgagatg  gctgcacac  1440
gagcaggat  ccatgctgg  ggacattga  gacttgacc  gacatgctg  aagtcagca  1500
aagcacatg  cagagaaaa  gcctgcaaa  tgaaaagaa  ccattcaac  agagaacaa  1560
ctagaattt  ttttgcttc  gtggttgta  aaatgctgt  gctaaaggt  gcgcagaaa  1620
aaatatcag  gttagtcat  gataatgtc  gaagcttaa  gtccagtga  tggcctttg  1680
ttcttaatt  attttaatt  tttacttgt  ccacttaat  tcaggcatt  taataaaat  1740
ttgttacaa  aaatgtaca  tactgacac  accacaaat  atggttaat  aaagagagt  1800
gttttaact  tatttttat  tgtttagag  ttttaagtt  gaacagtat  ttcccattg  1860
ctacttttc  ttcttcact  tagttttaa  gaagaactg  aaatgacgg  gctatacaa  1920
tcaaaaaat  catgcctgc  tcgtagtga  gttgtagct  tccgtaata  gtatatttt  1980
ctcagtttt  aacattttg  gaatgttga  tacctgaag  tccttttta  atgtgctat  2040
aacattctg  tggattcag  gggttcctt  aaagtttta  gtataaata  gtaaaataa  2100
aattaaaac  cg  2112



<210> 4577
<211> 487
<212> PRT
<213> Homo sapiens
<308> NP_055390
<400> 4577

Met Glu Arg Ser Gly Gln Arg Val Thr Thr Trp Asp Cys Asp Gln Gly 
  1               5                  10                  15
Lys His Ser Asp Ser Asp Tyr Arg Glu Asp Gly Met Asp Leu Gly Ser 
             20                  25                  30
Asp Ala Gly Ser Ser Ser Ser Ser Ser Arg Ala Ser Ser Gln Ser Asn 
         35                  40                  45
Ser Thr Lys Val Thr Pro Cys Ser Glu Cys Lys Ser Ser Ser Ser Pro 
     50                  55                  60
Gly Gly Ser Leu Asp Leu Val Ser Ala Leu Glu Asp Tyr Glu Glu Pro 
 65                  70                  75                  80
Phe Pro Val Tyr Gln Lys Lys Val Ile Asp Glu Trp Ala Pro Glu Glu 
                 85                  90                  95
Asp Gly Glu Glu Glu Glu Glu Glu Asp Glu Arg Asp Gln Arg Gly Tyr 
             100                105                110
Arg Asp Asp Arg Ser Pro Ala Arg Glu Pro Gly Asp Val Ser Ala Arg 
         115                120                125
Thr Arg Ser Gly Gly Gly Gly Gly Arg Ser Ala Thr Thr Ala Met Pro 
     130                135                140
Pro Pro Val Pro Asn Gly Asn Leu His Gln His Asp Pro Gln Asp Leu 
 145                150                155                160
Arg His Asn Gly Asn Val Val Val Ala Gly Arg Pro Ser Cys Ser Arg 
                 165                170                175
Gly Pro Arg Arg Ala Ile Gln Lys Pro Gln Pro Ala Gly Gly Arg Arg 
             180                185                190
Ser Gly Arg Gly Pro Ala Ala Gly Gly Leu Cys Leu Gln Pro Pro Asp 
         195                200                205
Gly Gly Thr Cys Val Pro Glu Glu Pro Pro Val Pro Pro Met Asp Trp 
     210                215                220
Glu Ala Leu Glu Lys His Leu Ala Gly Leu Gln Phe Arg Glu Gln Glu 
 225                230                235                240
Val Arg Asn Gln Gly Gln Ala Arg Thr Asn Ser Thr Ser Ala Gln Lys 
                 245                250                255
Asn Glu Arg Glu Ser Ile Arg Gln Lys Leu Ala Leu Gly Ser Phe Phe 
             260                265                270
Asp Asp Gly Pro Gly Ile Tyr Thr Ser Cys Ser Lys Ser Gly Lys Pro 
         275                280                285
Ser Leu Ser Ser Arg Leu Gln Ser Gly Met Asn Leu Gln Ile Cys Phe 
     290                295                300
Val Asn Asp Ser Gly Ser Asp Lys Asp Ser Asp Ala Asp Asp Ser Lys 
 305                310                315                320
Thr Glu Thr Ser Leu Asp Thr Pro Leu Ser Pro Met Ser Lys Gln Ser 
                 325                330                335
Ser Ser Tyr Ser Asp Arg Asp Thr Thr Glu Glu Glu Ser Glu Ser Leu 
             340                345                350
Asp Asp Met Asp Phe Leu Thr Arg Gln Lys Lys Leu Gln Ala Glu Ala 
         355                360                365
Lys Met Ala Leu Ala Met Ala Lys Pro Met Ala Lys Met Gln Val Glu 
     370                375                380
Val Glu Lys Gln Asn Arg Lys Lys Ser Pro Val Ala Asp Leu Leu Pro 
 385                390                395                400
His Met Pro His Ile Ser Glu Cys Leu Met Lys Arg Ser Leu Lys Pro 
                 405                410                415
Thr Asp Leu Arg Asp Met Thr Ile Gly Gln Leu Gln Val Ile Val Asn 
             420                425                430
Asp Leu His Ser Gln Ile Glu Ser Leu Asn Glu Glu Leu Val Gln Leu 
         435                440                445
Leu Leu Ile Arg Asp Glu Leu His Thr Glu Gln Asp Ala Met Leu Val 
     450                455                460
Asp Ile Glu Asp Leu Thr Arg His Ala Glu Ser Gln Gln Lys His Met 
 465                470                475                480
Ala Glu Lys Met Pro Ala Lys 
                 485



<210> 4578
<211> 602
<212> DNA
<213> Rattus norvegicus
<308> AA800054
<400> 4578

gacaaggac  aaggcttgt  ttattttaa  gactgatcc  cgtgaggcc  cagcctggc  60
actatgtac  gacacgagg  acgcttcat  tcttggtct  ttcctcctt  gacagagtc  120
tgatgatct  ctccttctt  gcttggagg  gctcctccc  acgctttcg  gcttccttg  180
tcttagacc  gcgagcctc  gcctggtca  ccagtagct  cttgcgggc  ttgtctgcc  240
tcagtttgt  gatgtgctc  atgagaatc  gcttgtttt  gaacacatt  cctttgacc  300
tcaggtaca  gctgtgata  atatgacgg  caatcttct  agattcccg  tatctcctg  360
gaagccggc  caggatcct  atccttcgc  tccaggtca  cttctcggg  atccgagcg  420
tggcagtac  cttcctctt  cctatgccc  tatgcctgc  cttccgtcg  gccaaggtg  480
tcttccggc  tcgagcccg  gaatggaca  tcacaggct  ccggatgat  aggccatct  540
gatcagctt  ctgatctgt  gacnaagtt  gcattggca  gttcgttgg  ttcattggg  600
tc  602



<210> 4579
<211> 196
<212> PRT
<213> Rattus norvegicus
<308> P14118
<400> 4579

Met Ser Met Leu Arg Leu Gln Lys Arg Leu Ala Ser Ser Val Leu Arg 
  1               5                  10                  15
Cys Gly Lys Lys Lys Val Trp Leu Asp Pro Asn Glu Thr Asn Glu Ile 
             20                  25                  30
Ala Asn Ala Asn Ser Arg Gln Gln Ile Arg Lys Leu Ile Lys Asp Gly 
         35                  40                  45
Leu Ile Ile Arg Lys Pro Val Thr Val His Ser Arg Ala Arg Cys Arg 
     50                  55                  60
Lys Asn Thr Leu Ala Arg Arg Lys Gly Arg His Met Gly Ile Gly Lys 
 65                  70                  75                  80
Arg Lys Gly Thr Ala Asn Ala Arg Met Pro Glu Lys Val Thr Trp Met 
                 85                  90                  95
Arg Arg Met Arg Ile Leu Arg Arg Leu Leu Arg Arg Tyr Arg Glu Ser 
             100                105                110
Lys Lys Ile Asp Arg His Met Tyr His Ser Leu Tyr Leu Lys Val Lys 
         115                120                125
Gly Asn Val Phe Lys Asn Lys Arg Ile Leu Met Glu His Ile His Lys 
     130                135                140
Leu Lys Ala Asp Lys Ala Arg Lys Lys Leu Leu Ala Asp Gln Ala Glu 
 145                150                155                160
Ala Arg Arg Ser Lys Thr Lys Glu Ala Arg Lys Arg Arg Glu Glu Arg 
                 165                170                175
Leu Gln Ala Lys Lys Glu Glu Ile Ile Lys Thr Leu Ser Lys Glu Glu 
             180                185                190
Glu Thr Lys Lys 
         195



<210> 4580
<211> 698
<212> DNA
<213> Homo sapiens
<308> NM_000981
<400> 4580

ctttccttt  gctgctgcg  ccgcagcca  gagtatgct  aggcttcag  agaggctcg  60
ctctagtgt  ctccgctgt  gcaagaaga  ggtctggtt  gaccccaat  agaccaatg  120
aatcgccaa  gccaactcc  gtcagcaga  ccggaagct  atcaaagat  ggctgatca  180
ccgcaagcc  gtgacggtc  attcccggg  tcgatgccg  aaaaacacc  tggcccgcc  240
gaagggcag  cacatgggc  taggtaagc  gaagggtac  gccaatgcc  gaatgccag  300
gaaggtcac  tggatgagg  gaatgagga  tttgcgccg  ctgctcaga  gataccgtg  360
atctaagaa  atcgatcgc  acatgtatc  cagcctgta  ctgaaggtg  aggggaatg  420
gttcaaaaa  aagcggatt  tcatggaac  catccacaa  ctgaaggca  acaaggccc  480
caagaagct  ctggctgac  aggctgagg  ccgcaggtc  aagaccaag  aagcacgca  540
gcgccgtga  gagcgcctc  aggccaaga  ggaggagat  atcaagact  tatccaagg  600
ggaagagac  aagaaataa  acctcccac  ttgtctgta  atactggcc  ctgtgatta  660
atagatcag  cattaaaat  aaacaagcc  taatctgc  698



<210> 4581
<211> 196
<212> PRT
<213> Homo sapiens
<308> P14118
<400> 4581

Met Ser Met Leu Arg Leu Gln Lys Arg Leu Ala Ser Ser Val Leu Arg 
  1               5                  10                  15
Cys Gly Lys Lys Lys Val Trp Leu Asp Pro Asn Glu Thr Asn Glu Ile 
             20                  25                  30
Ala Asn Ala Asn Ser Arg Gln Gln Ile Arg Lys Leu Ile Lys Asp Gly 
         35                  40                  45
Leu Ile Ile Arg Lys Pro Val Thr Val His Ser Arg Ala Arg Cys Arg 
     50                  55                  60
Lys Asn Thr Leu Ala Arg Arg Lys Gly Arg His Met Gly Ile Gly Lys 
 65                  70                  75                  80
Arg Lys Gly Thr Ala Asn Ala Arg Met Pro Glu Lys Val Thr Trp Met 
                 85                  90                  95
Arg Arg Met Arg Ile Leu Arg Arg Leu Leu Arg Arg Tyr Arg Glu Ser 
             100                105                110
Lys Lys Ile Asp Arg His Met Tyr His Ser Leu Tyr Leu Lys Val Lys 
         115                120                125
Gly Asn Val Phe Lys Asn Lys Arg Ile Leu Met Glu His Ile His Lys 
     130                135                140
Leu Lys Ala Asp Lys Ala Arg Lys Lys Leu Leu Ala Asp Gln Ala Glu 
 145                150                155                160
Ala Arg Arg Ser Lys Thr Lys Glu Ala Arg Lys Arg Arg Glu Glu Arg 
                 165                170                175
Leu Gln Ala Lys Lys Glu Glu Ile Ile Lys Thr Leu Ser Lys Glu Glu 
             180                185                190
Glu Thr Lys Lys 
         195



<210> 4582
<211> 648
<212> DNA
<213> Rattus norvegicus
<308> AA800062
<400> 4582

tgctgacat  gctgacagt  actgtttat  gagcatcat  acacaactg  gactgtcca  60
aactaaatg  gtacagtct  ccacaaaat  catttcact  tcaattgtg  aaattagga  120
gataacaag  tctgttcga  gttttcata  atacattga  ttctgaaaa  tattgttaa  180
actatattg  atgaaaatc  aaaaaaata  gattagaag  aaaaaacat  aaattgatt  240
tacatataa  aatttaacg  gttggggat  tagctcagt  gtagcgcac  tgcctagca  300
gcgcaaggc  ctgggtttg  tccccagct  cgaaaaaaa  aaaagaaaa  aaaaaaaga  360
tttaaaata  tgagtttgt  ctaagttct  gaactcaag  ttttgaagt  ttactggca  420
gcaaaataa  taggaaaaa  agaacacta  tccttaaaa  aaaaatact  cttttataa  480
tggtatttt  tactcctcg  naatacaat  tcgagagtc  gaagtccta  gattggccc  540
ttaaatagt  tcaaatatc  tcctgagga  tccagccaa  ataatgata  tgcactgct  600
tcactaaca  caaagttga  gacatgggg  tctaagaaa  aacaagag  648



<210> 4583
<211> 394
<212> PRT
<213> Rattus norvegicus
<308> NP_062708
<400> 4583

Met Arg Gly Gln Ser Leu Leu Thr Trp Val Leu Ala Ala Ala Val Thr 
  1               5                  10                  15
Cys Ala Gln Ala Gln Asp Val Pro Pro Trp Thr Glu Asp Cys Arg Lys 
             20                  25                  30
Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Pro Val Pro Trp 
         35                  40                  45
His Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu Leu 
     50                  55                  60
Leu Ala Gln Lys Ala Pro Ala Leu Arg Ile Leu Val Asn Ser Ile Thr 
 65                  70                  75                  80
Ser Leu Val Asn Thr Phe Val Pro Ser Gly Lys Leu Met Lys Met Val 
                 85                  90                  95
Asp Gln Lys Leu Pro Gly Met Ile Gly Ser Leu Pro Asp Pro Phe Gly 
             100                105                110
Glu Glu Met Arg Gly Ile Ala Asp Val Thr Gly Ile Pro Leu Gly Glu 
         115                120                125
Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Met Cys Thr Ser 
     130                135                140
Ile Ile Thr Glu Asp Glu Lys Gly His Leu Leu His Gly Arg Asn Met 
 145                150                155                160
Asp Phe Gly Ile Phe Leu Gly Trp Asn Ile Asn Asn Asn Thr Trp Val 
                 165                170                175
Val Thr Glu Glu Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln Arg 
             180                185                190
Asn Asn Lys Thr Val Phe Lys Ala Thr Ser Phe Val Gly Tyr Val Gly 
         195                200                205
Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Ser Leu Asn Glu 
     210                215                220
Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Met Phe 
 225                230                235                240
Gly Arg Lys Asp Ala Gln Trp Val Gly Phe Ile Thr Arg Ser Val Leu 
                 245                250                255
Glu Asn Thr Thr Ser Tyr Glu Glu Ala Lys Asn Thr Leu Thr Lys Thr 
             260                265                270
Lys Ile Met Ala Pro Val Tyr Phe Ile Leu Gly Gly Lys Lys Ser Gly 
         275                280                285
Glu Gly Cys Val Ile Thr Arg Glu Arg Lys Glu Ser Leu Asp Val Tyr 
     290                295                300
Glu Leu Asp Pro Lys His Gly Arg Trp Tyr Val Val Gln Thr Asn Tyr 
 305                310                315                320
Asp Arg Trp Lys Asn Thr Leu Phe Ile Asp Asp Arg Arg Thr Pro Ala 
                 325                330                335
Lys Lys Cys Leu Asn His Thr Thr Gln Lys Asn Leu Ser Phe Ala Thr 
             340                345                350
Ile Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr Val 
         355                360                365
Phe Thr Thr Leu Met Asp Val Thr Lys Gly Gln Phe Glu Ser His Leu 
     370                375                380
Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
 385                390



<210> 4584
<211> 2333
<212> DNA
<213> Homo sapiens
<308> NM_004315
<400> 4584

ggcacgagg  tagagcgat  ccgggccgg  gttgcgtcg  cttagtcct  ctggctgcc  60
ccgtcagct  tgccgtcgc  cagcacgcg  cgccgtgga  agaggactg  agaaaatca  120
cctatcctc  ttcaggacc  acgtacaga  gtgcagttc  atggtacac  ataaatctt  180
acttaccac  ctacaaaag  tggcatgaa  tgatgcttg  caaggcacc  atgctaaag  240
ttatagtga  ttctctgaa  aatatgata  atacattcg  gccaagtgg  aaagttatg  300
aggtggtgg  tgaaaaatt  cctggccta  ttggcaact  tcctggccc  tttgaagag  360
aaatgaagg  tattgccgc  gttactgat  tacctttag  agagattat  tcattcaat  420
ttttttatg  attatttac  atttgtact  caatagtag  agaagacaa  aaaggtcat  480
taatacatg  gagaaacat  gattttgga  tatttcttg  gtggaacat  aataatgat  540
cctgggtca  aactgagca  ctaaaacct  taacagtga  tttggattt  caaagaaac  600
acaaaactg  cttcaaggc  tcaagcttt  ctggctatg  gggcatgtt  acaggattc  660
aaccaggac  gttcagtct  acactgaat  aacgtttca  tataaatgg  ggttatctg  720
gtattctag  atggattct  ggaaagaaa  atgccatgt  gatagggtt  ctcactaga  780
cagttctgg  aaatagcac  agttatgaa  aagccaaga  tttattgac  aagaccaag  840
tattggccc  agcctactt  atcctggga  gcaaccagt  tggggaagg  tgtgtgatt  900
cacgagaca  aaaggaatc  ttggatgta  atgaactcg  tgctaagca  ggtagatgg  960
atgtggtac  aacaaatta  gaccgttgg  aacatccct  cttccttga  gatcgcaga  1020
cgcctgcaa  gatgtgtct  aaccgcacc  gccaagaga  tatctcatt  gaaaccatg  1080
atgatgtcc  gtcaacaaa  cctgtcctc  acaagctga  cgtatacac  accttgata  1140
atgttacca  aggtcaatt  gaaacttac  tgcgggact  ccctgaccc  tgtataggt  1200
ggtgagcac  cgtctggcc  acagaatgc  gcctctgag  catgaagac  ccatctcca  1260
gtgaccgaa  actgcagct  tctgacctt  caaagacta  gactcgcgg  aggttctct  1320
tgagtcaat  gcttgtctt  gtccatctg  tgacaaatg  cagatcttt  tttttttcc  1380
cctatcagt  gatttttct  atttacaga  aacttcttt  ggggaagta  aacagtcat  1440
tagaattca  tgagttttg  ttcactttg  catttgggg  tctggtggg  agtcgaacc  1500
tggtgaact  cacctccgt  gaataaatg  agattcagc  tgggtgttg  atccagcac  1560
tctgtgtga  taacgggac  gtaaacact  cacattctt  agtttttca  ttctaccta  1620
atatttgta  gtttttctg  ataacagcc  tttccttct  gttctaact  ctgttaaaa  1680
taatatatc  ttatctttg  tgttattga  agcgatatt  ttttattac  tatcattag  1740
gggatgaga  agacattca  ctgtatatt  cttttaatg  gcacaaaat  ggcccttgc  1800
tctaaatag  actttttgg  gttcaagaa  taatcagta  gcaaagcaa  cttttatac  1860
ataattgaa  tgttccctt  ttcataatt  ctctacttc  cagtaaccc  aaggaagtt  1920
ctaacttaa  aaactgcat  ccacgttct  ttaatttag  aaataaaca  gtcaaagac  1980
tgtggaaaa  aggaagtga  cccatattt  aaattctca  aagtagcat  gatgtaata  2040
acaggtttt  agtttgttc  tcagattga  agggagttt  aaagaaatt  tagtagtta  2100
taaaattat  ttactgtat  tttcagaaa  caaactgct  atgaaaagt  ctaatagaa  2160
ttgttaacc  ttctaacct  cacgattaa  tgtgaaatg  acgtcattt  tgcaagacc  2220
tttgtccac  tcattttgt  taatcacag  tgtgttcct  acactcaat  aacagtcac  2280
ggaaagagt  ccagtcagc  gtcatgcac  ctgataaaa  aaaaaaaaa  aaa  2333



<210> 4585
<211> 395
<212> PRT
<213> Homo sapiens
<308> Q13510
<400> 4585

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
  1               5                  10                  15
Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
             20                  25                  30
Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
         35                  40                  45
Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
     50                  55                  60
Leu Met Leu Asp Lys Ala Pro Met Leu Lys Val Ile Val Asn Ser Leu 
 65                  70                  75                  80
Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Val Met Gln Val 
                 85                  90                  95
Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
             100                105                110
Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
         115                120                125
Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr 
     130                135                140
Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn 
 145                150                155                160
Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp 
                 165                170                175
Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln 
             180                185                190
Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val 
         195                200                205
Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn 
     210                215                220
Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile 
 225                230                235                240
Leu Gly Lys Lys Asp Ala Met Trp Ile Gly Phe Leu Thr Arg Thr Val 
                 245                250                255
Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys 
             260                265                270
Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser 
         275                280                285
Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val 
     290                295                300
Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn 
 305                310                315                320
Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro 
                 325                330                335
Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu 
             340                345                350
Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr 
         355                360                365
Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr 
     370                375                380
Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
 385                390                395



<210> 4586
<211> 374
<212> DNA
<213> Rattus norvegicus
<308> AA800126
<400> 4586

ctttaattt  tattcaggg  tccaagaat  ttagtaatt  ttaactgaa  agcatatca  60
tacctgcct  ttttaaggt  tactatcac  agccttata  ctatttata  aaagtataa  120
tttaaatct  acccatttc  tctttcaag  ctcataaga  tttcttgcc  gagactggt  180
atattttat  attcttgga  ccctgcaat  ttcccaaac  actgcattc  cctttttgc  240
ataccaaac  ggagctggt  attcttagt  gagtcattt  acctagggg  ccacggtac  300
gcgataagt  actcaatta  taccttatg  ttgacagtt  acactggaa  caaaggtga  360
ttcatggga  taga  374



<210> 4587
<211> 2595
<212> DNA
<213> Homo sapiens
<308> L10910
<400> 4587

cgggctggg  ggttccgcg  cctgggcct  ggggcttaa  agtagcaac  gaagcggcg  60
cggcggcag  agcagcagc  gcagcagca  tctcttccc  aacacgagc  ccacaggcg  120
ccgaaggcc  gaacaggcg  ttagagaaa  tggcagacg  tattgatat  gaagcaatg  180
ttgaggctc  ttacaagaa  gatgagaac  agttgagca  tgccaacgg  catgaagaa  240
gtagcaaaa  gaggaaaaa  agcaagagc  gaagtcgta  tcatgaacg  aagagaagc  300
aaagtaagg  acggaagcg  agtagagac  gagaaagga  aaagagcaa  agccgtgaa  360
gaaagcgaa  tagaagcaa  gagaggcga  ggagccgct  aagaagtcg  gatcgaaga  420
ttagaggcc  ctacagaag  ccttactcc  gaccaaaat  taacagtgc  atccgagga  480
agattgggt  gcctcatag  atcaaatta  gcagacgac  ttcccgaag  aaaagtcca  540
tcagaaaag  caagagccc  gtgagagaa  ctattgata  tttaactcc  gaggaaaga  600
atgcaagga  agtcttctg  atgcagctg  cggcaagaa  tcgaccaag  gatttggaa  660
agtttttct  tacagtagg  aaggttcga  atgtgagga  gatttctga  agaaattca  720
gacgttcca  aggaattgc  tatgtggag  tcgtcgatg  tagctcagt  cctctagca  780
taggattaa  tggccaacg  gttttaggc  tgccaatca  agtacaggc  tcacaggca  840
aaaaaaaca  agctgcagc  atggcaaac  atttacaaa  gggaagtgc  ggacctatg  900
ggctttatg  gggctcatt  cacttcaac  taactgaag  tatgcttcg  gggatcttt  960
agccttttg  aagaattga  agtatccag  tgatgatgg  cagtgaaac  ggtcgatcc  1020
agggatatg  atttattac  ttttctgac  cagaatgtg  caaaaaggc  ttggaacaa  1080
ttaatggat  tgaactagc  ggaagacca  tgaaagttg  tcatgttac  gaacgtact  1140
atgcttcga  tgctagttc  tttttggac  gtgatgaac  ggaaaggac  ggaattgat  1200
tgggaacaa  tggtcgtct  cagttaatg  caagacttg  agagggtac  ggtttgcag  1260
ttccgccag  agcacagca  gctctacag  tgagtggct  tttggcatt  ggtgctgtg  1320
cagatttgc  aacaagact  tcccagcag  ctgaagctt  agctttagc  gcagctgcc  1380
ctgttcagc  acttgcaac  caatgtttc  aactctcta  catgtttaa  cctcaaaca  1440
aagaagaag  tggatggga  accgagatt  aggatgatg  gattgaaga  tgtaataaa  1500
atggaggag  tattcatat  tatgttgac  aaaattcag  tcagggcaa  gtgtatgtg  1560
agtgcccat  aattgctgc  gctattgct  ctgtcaatg  attgcatgg  aggtggttt  1620
ctggtaaaa  gataacagc  gcatatgta  ctcttccaa  ttaccacaa  ctgtttcct  1680
attctatga  agcaacaca  ctactggtt  caagtagac  atgaaggaa  atatagtcc  1740
ttatgtata  agctttttt  ctttcttga  aattcatct  gagttatct  ttatttaga  1800
aaaaataaa  aggcaagga  ctactgtca  ttgtatgca  tttcctgtt  ccttgaaaa  1860
ataaaaatg  taacaggaa  gcagtgtgc  cattctccc  aaatagtaa  tcccactgt  1920
tacaaaact  ttctcttgt  ctgcctttt  aaatgttca  gtagaaaat  aatgaacta  1980
aggaatagc  ctaggagaa  aaatgtgct  tctgtaaaa  ggcagacca  ggatgtaat  2040
tttttaatg  ttcagaagc  taacttttt  cacagtggt  acatttcac  tttcactaa  2100
gttgatatt  ggctgatgg  tgagcagtt  ctgaaatac  catttagtg  atggaaata  2160
aagacagct  aagggctgt  tggttagca  ctcatcttg  attctgatc  attggcaag  2220
aagggagat  tcaaaatta  atttcttga  ggtatcttt  caattaatg  atctgtaaa  2280
gtttctttg  aaatactat  tgttctggt  tgtcttaaa  ttccaaaca  aatgatccc  2340
gcatttcct  aagatgttt  aacgtgaga  tctggtagg  aaagcagtc  gagaaagaa  2400
taggaaatg  agaaatagg  tttgtctgg  tgcatataa  ctttgctct  tttaagctc  2460
gtgagctct  aaatatatt  ttgggttac  tcagtgtgt  tgacaagac  gcttgatat  2520
tctatcaaa  aaatgactt  catattgca  caatctttg  aagaaccac  caaataaaa  2580
tctcttaaa  aggcc  2595



<210> 4588
<211> 136
<212> PRT
<213> Homo sapiens
<308> CAC11116
<400> 4588

Met Leu Leu Arg Ala Ala Trp Arg Arg Ala Ala Val Ala Val Thr Ala 
  1               5                  10                  15
Ala Pro Gly Pro Lys Pro Ala Ala Pro Thr Arg Gly Leu Arg Leu Arg 
             20                  25                  30
Val Gly Asp Arg Ala Pro Gln Ser Ala Val Pro Ala Asp Thr Ala Ala 
         35                  40                  45
Ala Pro Glu Val Gly Pro Val Leu Arg Pro Leu Tyr Met Asp Val Gln 
     50                  55                  60
Ala Thr Thr Pro Leu Asp Pro Arg Val Leu Asp Ala Met Leu Pro Tyr 
 65                  70                  75                  80
Leu Ile Asn Tyr Tyr Gly Asn Pro His Ser Arg Thr His Ala Tyr Gly 
                 85                  90                  95
Trp Glu Ser Glu Ala Ala Met Glu Arg Ala Arg Gln Gln Val Ala Ser 
             100                105                110
Leu Ile Gly Ala Asp Pro Arg Glu Ile Ile Phe Thr Ser Gly Ala Thr 
         115                120                125
Glu Ser Asn Asn Ile Ala Ile Lys 
     130                135



<210> 4589
<211> 383
<212> DNA
<213> Rattus norvegicus
<308> AA800168
<400> 4589

ccagtgtca  attttattg  caattcgca  ggtacagca  ttcagtggc  gcaatctgc  60
aaatattcc  gcagtcctg  cagtcctgg  tgaggcaaa  atgggttat  ttattctag  120
cttaattac  ctcacgata  actacatat  acacagtaa  tctctctct  tctgtatat  180
tctacgtgc  gattatgga  tggctgtaa  gggttaaag  tgcaaggag  ttgagtttc  240
aacaggcca  ttgggaaac  caggccact  gtctctgat  acggcctaa  gggactgga  300
aacttggcg  agctgtggc  gtaagtcaa  accctgggt  gtaggtttg  caatgaagc  360
gcaaagctg  gtccagctt  ttc  383



<210> 4590
<211> 576
<212> DNA
<213> Rattus norvegicus
<308> AA800177
<400> 4590

agattacag  gcacagtca  aggcttcct  gggccagtg  ccttttcaa  tgagtcctt  60
tactggcaa  ctttaagaa  gcaaagggc  agagactac  atctttctg  aaaatggta  120
aggcccaga  atgtaactg  agtccagtc  gggcccggc  ccactacag  acgcattaa  180
ctattaggt  tttaggaac  cagtaagca  taagaaatg  tttgaatgc  gcaagagtt  240
aagtgctta  ctaaaacaa  ctgtcagcc  gttgagttc  acaacaatc  taagatgac  300
catgcttgc  tttgtttat  aatgctggg  gaccacact  ccatgaatt  ctttagtgc  360
acactaaac  accaaaact  gaaaaacct  ccacttcta  agagagaga  aggccttag  420
aactctgag  aattacccc  tgggtggta  tcacacact  aggattgct  gaagagttt  480
cagagttat  acttaaaaa  aaattactc  attttagaa  ccactcaat  tataagatg  540
tttagtaaa  agatgcact  tangaactt  cttttc  576



<210> 4591
<211> 576
<212> DNA
<213> Rattus norvegicus
<308> AA800177
<400> 4591

agattacag  gcacagtca  aggcttcct  gggccagtg  ccttttcaa  tgagtcctt  60
tactggcaa  ctttaagaa  gcaaagggc  agagactac  atctttctg  aaaatggta  120
aggcccaga  atgtaactg  agtccagtc  gggcccggc  ccactacag  acgcattaa  180
ctattaggt  tttaggaac  cagtaagca  taagaaatg  tttgaatgc  gcaagagtt  240
aagtgctta  ctaaaacaa  ctgtcagcc  gttgagttc  acaacaatc  taagatgac  300
catgcttgc  tttgtttat  aatgctggg  gaccacact  ccatgaatt  ctttagtgc  360
acactaaac  accaaaact  gaaaaacct  ccacttcta  agagagaga  aggccttag  420
aactctgag  aattacccc  tgggtggta  tcacacact  aggattgct  gaagagttt  480
cagagttat  acttaaaaa  aaattactc  attttagaa  ccactcaat  tataagatg  540
tttagtaaa  agatgcact  tangaactt  cttttc  576



<210> 4592
<211> 552
<212> DNA
<213> Rattus norvegicus
<308> AA800184
<400> 4592

aaggctgtc  atagcttta  tgaaatcgg  ataaataaa  atgcacatt  caaatgtaa  60
ctcaagtga  cccaagtgc  aacaaaata  taacctctg  catgcagga  gttgtgttt  120
catttaaaa  aaaaaaaga  agagagata  aaagaagaa  aaaagagaa  agaaaagaa  180
aaagaaaca  cacccgaag  agcttttaa  agaccagga  gaaaaacca  ctttaatat  240
aagatataa  gcaaagcca  gatcaacat  ccttactta  cctggtcaa  tgcactttt  300
tccctttct  ttaaaatgc  aacataaat  aataattta  caaaatgtg  actcacaga  360
tgaactttt  tttacaata  acaatttat  acctattgt  tttgattag  tcaagtgaa  420
aacattata  tttttgctt  aataacagt  ggacacaaa  cgatttctc  ggtagtcgg  480
tgtgaaatg  gccccagca  ttagtttcc  attaaaggc  gtattgcct  ccaatcatc  540
atacattct  tc  552



<210> 4593
<211> 4602
<212> DNA
<213> Homo sapiens
<308> AB011101
<400> 4593

atggcggaa  gcggagcgg  ggatctgga  acccagcgg  ctgacatcg  gacgctgct  60
aaaacctcg  tccggaaag  ggacacctg  tacctagtc  atagtcgct  gttcaaaca  120
tggaaaaaa  atgttggct  tgacagttg  gacaaatac  agatgggag  tcaaaatgt  180
tatcctgga  ccattgata  ctctggact  ctcaaagat  gtgatgccc  gtcacttaa  240
gaacatctt  ttgatgaat  ggattacat  ctgttgcca  ctgaaggtt  gaataaact  300
gtcagctgg  acacattga  ggaaggtca  gagccaata  cacgaaagg  ggttgaaca  360
ggtatgttt  taaagcact  caaagtaga  gtatatctc  cagaattga  gctatgtga  420
aatggaaac  tgaataatg  tgtaactcg  agatttagc  aagctgaca  aatagatac  480
attgaaaag  aaataagaa  aatcttcag  attccagat  aaaaggaga  cagattgtg  540
aacaaatac  tgagtaaca  atttgaacc  ctgaataaa  cagacagca  cattcagga  600
gctggttta  accaaggac  ggtattagt  atagaacag  aaaatgaag  tggaacatg  660
ccaaggggt  cttctactc  taatgtgaa  aactcaaat  actgtcttc  atcatatac  720
gcttataag  actatgatt  ttcggaacc  ggaagaaac  atgaacagc  aggcctctg  780
ggcctaagt  acttgggaa  tacgtgttt  atgaactca  ctattcagt  tttgagcaa  840
acacctcca  ttactgagt  tttcctcaa  gataagtat  aagaagaac  gaattttga  900
aatccctta  gaatgagag  tgaaatagc  aaatcttat  ccgaactga  caagcaaat  960
tggtctgga  agtttagct  cgtcacccc  agagccttt  agacacagg  aggacgttt  1020
gcacctcag  tctctggat  tcagcagca  gactgtcaa  aactgttag  tttcctatt  1080
gatggatta  atgaggatt  gaatagaat  aggaaaaaa  catatatac  attaaaaga  1140
gcagatgga  ggccagata  ggtggttgc  gaagaagcc  gggaaaacc  tttaaaacg  1200
aatgattct  tcatagtag  tatatttca  ggccttttc  aatcaactt  agtttgtcc  1260
gagtgtgct  agatttcag  aacatttga  cctttttgt  acttgacac  tccattgcc  1320
atgaaaaaa  aacgcacct  ggaagttta  ttagttaga  tggatccgc  taccaaacc  1380
atgcagtac  aagtggttg  ccccaaaat  ggaaacata  tagatcttt  tacagcatt  1440
tctgctttg  caggaatac  tgcagataa  atgatagtt  ctgatatat  caatcatag  1500
tttcacaga  tattcgcta  ggatgaaaa  cttagtagt  ttatggaac  ggatgatat  1560
tatgtgttt  aaattaaca  caataggac  gaagataca  agcacgtga  tattcctgt  1620
tgcctaaga  aaaaattca  acactcgag  tatacccac  atactggtt  ttcactttt  1680
ggtcagccc  ttcttatgg  tgtaccacg  aacaatact  aagacaaac  ttataatct  1740
ctgctcttg  gaatgtgcc  atatgtcaa  atatctact  aaactgaag  aactgaagg  1800
tccctacac  gctgtaagg  ccaaaatat  aatgggaat  gcccaaatg  catacatga  1860
gaaggctca  caagtgaaa  ggaaacaga  gagccagat  atgaatcca  ccaggatca  1920
gaacttccc  cagagaatg  aaacagtca  tctgaagat  cagttggag  agataatga  1980
tctgaaaat  gattatgta  tgaggatac  tgcaaaggt  aactcacgg  acacaaaaa  2040
cgattgttt  cattccagt  caacaactt  ggcaatact  atatcaact  catcaaaga  2100
gataccagg  atataagat  tgatgatag  cagcttagg  tagatgaaa  atcttttct  2160
gctttggat  gggatcctg  tttgaaaaa  agatatttt  atgaaaatg  tgctgagga  2220
tttgaaaaa  atgaaagtg  ggagtataa  cctcctaaa  aaccctttg  gaaattaaa  2280
gattgcatt  aacttttta  aacaaaaga  aagctaggt  ctgaagatc  ctggtattg  2340
ccgaattgt  aagaacatc  gcaagccac  aagaaattg  atttatggt  cctgcctcc  2400
gtacttgta  tacatctca  gcgattttc  tacagtcga  acatgagag  caagttgga  2460
accttagtt  attttccta  caatgactt  gatatgtcg  aattcttaa  taatccaaa  2520
gcaggtcct  gccgctata  tctgattgc  gtttccaac  actatggag  gatgggagg  2580
ggacactat  ctgcttttg  aaaaaataa  gatgatgga  aatggtact  ttttgatga  2640
agtagtgtc  ccactgcat  tgaagacca  attgtgtcc  aagcagcat  tgtactctt  2700
taccagaga  aagacactt  cagtggaac  ggctttttt  ctcttgacc  agaaactaa  2760
ggtgcttca  ctgccactg  catcccatt  gaaagtgat  aagatagca  tgataatga  2820
aatgatata  aaaatgaaa  ctgtatgca  actaactaa  gaaagtcct  gaagccata  2880
aagagacac  ttcctgctg  tggtatcta  ggaaatgat  aagttaccc  ccacattaa  2940
acaaaagtc  gagatgggg  gtttcagat  accgaatgt  aatccttta  cagatttta  3000
cttgtgcag  acttgaagt  aaacacaat  aaaacttta  cagaaattg  ctcttaata  3060
atttacagt  ttgtattta  aagctaaat  tatatagga  atcacaaat  aatcccttt  3120
aagtttgct  ctgttttga  taattatgt  tcctttaat  ttttggatg  gagttgatg  3180
caaatgtta  atttgtgga  gttggtcat  tattttgct  taataatac  gcaagaaaa  3240
tatggctga  cttagtttt  ggataatct  gttcatgtg  attaggctg  cgtatatac  3300
actatgata  ttagctgca  tatcaatgt  gcataaata  tgcggcagc  ttcttcgaa  3360
accgcattt  caaatttat  cccgtaatc  atgtgggcc  attaaaaaa  caaatcatg  3420
tacaagaaa  aaccttgga  aagttattt  cctttgtaa  acctttaaa  atccagagt  3480
ttatattca  tttactgcc  ctgtggaaa  aggttctag  tttcatact  catctaaag  3540
catttttca  ttacatgta  gtattattt  ctgctattg  gatctattc  tcagatatt  3600
aaaaacatt  tttgcttta  aatgcatat  tttaattgg  tgttggtcc  aaattaaaa  3660
ttttgctgt  tgtttttct  taccccatt  tgtggtaat  tggcaactt  agctctccc  3720
attattgta  tataaggac  gacataata  tattctgta  ccatagtaa  aattgcatc  3780
agcttagat  agaaatttt  ttcatatac  ggcctttaa  tcattaatg  acaattggc  3840
ataaaggta  gtctgttaa  tttctttgt  tgttcctga  ggaattcac  atagcctta  3900
agcttttct  agaaggtaa  ttgttataa  agaaatggc  tttgcatgt  ccagagtca  3960
aacctgtac  gtatataaa  cataaacac  ttgaatttg  ttttagttc  ccacattca  4020
ggatccagg  tgccaaaaa  atgtgtgaa  atttgaaac  tttttattt  ctgcttttt  4080
cctttgata  agttgaaag  atgtattgt  aattggcat  caatactgc  tttaataga  4140
aacctaaat  ctggggcac  tttcacata  cgactacct  agaaattgc  ttgtgtccc  4200
ctgttatta  agcaaaaag  ataatgttc  tcacttgaa  taatcaaat  caatagatt  4260
taaattgtg  attgtaaat  aaagttcac  ctgtgagtg  acattttgg  aaattattt  4320
tttatgtta  catttaaaa  tttaaaaaa  atgcatttg  ccaggataa  tgaggtatg  4380
tgatcatgg  tttgcttta  atcttgata  taaagctgg  ttatcatcc  ggtatttta  4440
aagctgctt  ggggttttt  ttttctttt  ttttttttt  atgtaaact  acctcctgc  4500
tgacagagg  taaaatttt  tctgcactt  agttcactt  agtttacat  tgaaatgtg  4560
atgtttatt  atatagatt  caataaagc  attcaaggc  tt  4602



<210> 4594
<211> 902
<212> PRT
<213> Homo sapiens
<308> Q9Y4E8
<400> 4594

Met Gly Asp Gln Asn Val Tyr Pro Gly Pro Ile Asp Asn Ser Gly Leu 
  1               5                  10                  15
Leu Lys Asp Gly Asp Ala Gln Ser Leu Lys Glu His Leu Ile Asp Glu 
             20                  25                  30
Leu Asp Tyr Ile Leu Leu Pro Thr Glu Gly Trp Asn Lys Leu Val Ser 
         35                  40                  45
Trp Tyr Thr Leu Met Glu Gly Gln Glu Pro Ile Ala Arg Lys Val Val 
     50                  55                  60
Glu Gln Gly Met Phe Val Lys His Cys Lys Val Glu Val Tyr Leu Thr 
 65                  70                  75                  80
Glu Leu Lys Leu Cys Glu Asn Gly Asn Met Asn Asn Val Val Thr Arg 
                 85                  90                  95
Arg Phe Ser Lys Ala Asp Thr Ile Asp Thr Ile Glu Lys Glu Ile Arg 
             100                105                110
Lys Ile Phe Ser Ile Pro Asp Glu Lys Glu Thr Arg Leu Trp Asn Lys 
         115                120                125
Tyr Met Ser Asn Thr Phe Glu Pro Leu Asn Lys Pro Asp Ser Thr Ile 
     130                135                140
Gln Asp Ala Gly Leu Tyr Gln Gly Gln Val Leu Val Ile Glu Gln Lys 
 145                150                155                160
Asn Glu Gln Lys Asn Glu Asp Gly Thr Trp Pro Arg Gly Pro Ser Thr 
                 165                170                175
Pro Asn Val Lys Asn Ser Asn Tyr Cys Leu Pro Ser Tyr Thr Ala Tyr 
             180                185                190
Lys Asn Tyr Asp Tyr Ser Glu Pro Gly Arg Asn Asn Glu Gln Pro Gly 
         195                200                205
Leu Cys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ala 
     210                215                220
Ile Gln Cys Leu Ser Asn Thr Pro Pro Leu Thr Glu Tyr Phe Leu Asn 
 225                230                235                240
Asp Lys Tyr Gln Glu Glu Leu Asn Phe Asp Asn Pro Leu Gly Met Arg 
                 245                250                255
Gly Glu Ile Ala Lys Ser Tyr Ala Glu Leu Ile Lys Gln Met Trp Ser 
             260                265                270
Gly Lys Phe Ser Tyr Val Thr Pro Arg Ala Phe Lys Thr Gln Val Gly 
         275                280                285
Arg Phe Ala Pro Gln Phe Ser Gly Tyr Gln Gln Gln Asp Cys Gln Glu 
     290                295                300
Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Ile 
 305                310                315                320
Arg Lys Lys Pro Tyr Ile Gln Leu Lys Asp Ala Asp Gly Arg Pro Asp 
                 325                330                335
Lys Val Val Ala Glu Glu Ala Trp Glu Asn His Leu Lys Arg Asn Asp 
             340                345                350
Ser Ile Ile Val Asp Ile Phe His Gly Leu Phe Lys Ser Thr Leu Val 
         355                360                365
Cys Pro Glu Cys Ala Lys Ile Ser Val Thr Phe Asp Pro Phe Cys Tyr 
     370                375                380
Leu Thr Leu Pro Leu Pro Met Lys Lys Glu Arg Thr Leu Glu Val Tyr 
 385                390                395                400
Leu Val Arg Met Asp Pro Leu Thr Lys Pro Met Gln Tyr Lys Val Val 
                 405                410                415
Val Pro Lys Ile Gly Asn Ile Leu Asp Leu Cys Thr Ala Leu Ser Ala 
             420                425                430
Leu Ser Gly Ile Pro Ala Asp Lys Met Ile Val Thr Asp Ile Tyr Asn 
         435                440                445
His Arg Phe His Arg Ile Phe Ala Met Asp Glu Asn Leu Ser Ser Ile 
     450                455                460
Met Glu Arg Asp Asp Ile Tyr Val Phe Glu Ile Asn Ile Asn Arg Ala 
 465                470                475                480
Glu Asp Thr Glu His Val Ile Ile Pro Val Cys Leu Arg Glu Lys Phe 
                 485                490                495
Arg His Ser Ser Tyr Thr His His Thr Gly Ser Ser Leu Phe Gly Gln 
             500                505                510
Pro Phe Leu Met Ala Val Pro Arg Asn Asn Thr Glu Asp Lys Leu Tyr 
         515                520                525
Asn Leu Leu Leu Leu Arg Met Cys Arg Tyr Val Lys Ile Ser Thr Glu 
     530                535                540
Thr Glu Glu Thr Glu Gly Ser Leu His Cys Cys Lys Asp Gln Asn Ile 
 545                550                555                560
Asn Gly Asn Gly Pro Asn Gly Ile His Glu Glu Gly Ser Pro Ser Glu 
                 565                570                575
Met Glu Thr Asp Glu Pro Asp Asp Glu Ser Ser Gln Asp Gln Glu Leu 
             580                585                590
Pro Ser Glu Asn Glu Asn Ser Gln Ser Glu Asp Ser Val Gly Gly Asp 
         595                600                605
Asn Asp Ser Glu Asn Gly Leu Cys Thr Glu Asp Thr Cys Lys Gly Gln 
     610                615                620
Leu Thr Gly His Lys Lys Arg Leu Phe Thr Phe Gln Phe Asn Asn Leu 
 625                630                635                640
Gly Asn Thr Asp Ile Asn Tyr Ile Lys Asp Asp Thr Arg His Ile Arg 
                 645                650                655
Phe Asp Asp Arg Gln Leu Arg Leu Asp Glu Arg Ser Phe Leu Ala Leu 
             660                665                670
Asp Trp Asp Pro Asp Leu Lys Lys Arg Tyr Phe Asp Glu Asn Ala Ala 
         675                680                685
Glu Asp Phe Glu Lys His Glu Ser Val Glu Tyr Lys Pro Pro Lys Lys 
     690                695                700
Pro Phe Val Lys Leu Lys Asp Cys Ile Glu Leu Phe Thr Thr Lys Glu 
 705                710                715                720
Lys Leu Gly Ala Glu Asp Pro Trp Tyr Cys Pro Asn Cys Lys Glu His 
                 725                730                735
Gln Gln Ala Thr Lys Lys Leu Asp Leu Trp Ser Leu Pro Pro Val Leu 
             740                745                750
Val Val His Leu Lys Arg Phe Ser Tyr Ser Arg Tyr Met Arg Asp Lys 
         755                760                765
Leu Asp Thr Leu Val Asp Phe Pro Ile Asn Asp Leu Asp Met Ser Glu 
     770                775                780
Phe Leu Ile Asn Pro Asn Ala Gly Pro Cys Arg Tyr Asn Leu Ile Ala 
 785                790                795                800
Val Ser Asn His Tyr Gly Gly Met Gly Gly Gly His Tyr Thr Ala Phe 
                 805                810                815
Ala Lys Asn Lys Asp Asp Gly Lys Trp Tyr Tyr Phe Asp Asp Ser Ser 
             820                825                830
Val Ser Thr Ala Ser Glu Asp Gln Ile Val Ser Lys Ala Ala Tyr Val 
         835                840                845
Leu Phe Tyr Gln Arg Gln Asp Thr Phe Ser Gly Thr Gly Phe Phe Pro 
     850                855                860
Leu Asp Arg Glu Thr Lys Gly Ala Ser Ala Ala Thr Gly Ile Pro Leu 
 865                870                875                880
Glu Ser Asp Glu Asp Ser Asn Asp His Asp Asn Asp Ile Glu Asn Glu 
                 885                890                895
Asn Cys Met His Thr Asn 
             900



<210> 4595
<211> 693
<212> DNA
<213> Rattus norvegicus
<308> AA800190
<400> 4595

atgggtata  aagtttaat  catttctct  acaaggagg  aacagtaaa  agtagaggg  60
tgatcatgt  ttatggctt  aagggacct  atgcacagg  cagcagatg  ccagcccca  120
aacctgccc  cccaccccc  aagctacca  agtggttcc  gtgaattga  tgctgaaaa  180
agacacctc  cagtaaaca  tgccagggt  gaggaaagt  aggcgtttt  ctgcccatc  240
cgaaccaga  acagcaatg  aaggtggtg  atctctgga  ggagtttta  gtagttctc  300
gacaaccct  ctctgccct  agggaggag  atggctcct  tagtgggtg  gcttaaccg  360
tctttctca  tatgctgct  tagcagagt  ggaaccagg  cctactgca  gactagcag  420
tgagtcagc  agggcagaa  tatccagac  gaccaagta  aaggtttac  tgcaaaaaa  480
ggaaggctt  agctagttt  aattcctca  gaagtgtta  ttcctgttg  aaaagcaaa  540
gactaagcc  accgtctat  aaattgcca  tccttaacc  aggcctcaa  tatgggata  600
aggtctctc  ttagtctcc  cttcagggt  ctggggttc  acatgacac  cacagggtt  660
tacaggtgg  tacagaggc  tggccccat  tgg  693



<210> 4596
<211> 838
<212> PRT
<213> Rattus norvegicus
<308> AAA41252
<400> 4596

Met Ala Lys Pro Leu Thr Asp Ser Glu Arg Gln Lys Gln Ile Ser Val 
  1               5                  10                  15
Arg Gly Ile Ala Gly Leu Gly Asp Val Ala Glu Val Arg Lys Ser Phe 
             20                  25                  30
Asn Arg His Leu His Phe Thr Leu Val Lys Asp Arg Asn Val Ala Thr 
         35                  40                  45
Pro Arg Asp Tyr Phe Phe Ala Leu Ala His Thr Val Arg Asp His Leu 
     50                  55                  60
Val Gly Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Glu Arg Asp Pro 
 65                  70                  75                  80
Lys Arg Ile Tyr Tyr Leu Ser Leu Glu Phe Tyr Met Gly Arg Thr Leu 
                 85                  90                  95
Gln Asn Thr Met Val Asn Leu Gly Leu Gln Thr Ala Cys Asp Glu Ala 
             100                105                110
Thr Tyr Gln Leu Gly Leu Asp Leu Glu Glu Leu Glu Glu Ile Glu Glu 
         115                120                125
Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe 
     130                135                140
Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile 
 145                150                155                160
Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile Val Asn Gly Trp Gln 
                 165                170                175
Val Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys 
             180                185                190
Ala Arg Pro Glu Tyr Met Leu Pro Val His Phe Tyr Gly Arg Val Glu 
         195                200                205
His Thr Pro Asn Gly Val Leu Trp Leu Asp Thr Gln Val Val Leu Ala 
     210                215                220
Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Lys Asn Asn Thr Val Asn 
 225                230                235                240
Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Asn Asp Phe Lys Leu Lys 
                 245                250                255
Asp Phe Asn Val Gly Asp Tyr Ile Glu Ala Val Leu Asp Arg Asn Leu 
             260                265                270
Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Asn Phe Phe Glu 
         275                280                285
Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr 
     290                295                300
Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser Lys Phe Gly Cys Arg 
 305                310                315                320
Asp Pro Val Arg Thr Cys Phe Glu Thr Phe Pro Asp Lys Val Ala Ile 
                 325                330                335
Gln Leu Asn Asp Thr His Pro Ala Leu Ser Ile Pro Glu Leu Met Arg 
             340                345                350
Ile Leu Val Asp Val Glu Lys Val Asp Trp Asp Lys Ala Trp Glu Ile 
         355                360                365
Thr Lys Lys Thr Cys Ala Tyr Thr Asn His Thr Val Leu Pro Glu Ala 
     370                375                380
Leu Glu Arg Trp Pro Val Ser Met Phe Glu Lys Leu Leu Pro Arg His 
 385                390                395                400
Leu Glu Ile Ile Tyr Ala Ile Asn Gln Arg His Leu Asp His Val Ala 
                 405                410                415
Ala Leu Phe Pro Gly Asp Val Asp Arg Leu Arg Arg Met Ser Val Ile 
             420                425                430
Glu Glu Gly Asp Cys Lys Arg Ile Asn Met Ala His Leu Cys Val Ile 
         435                440                445
Gly Ser His Ala Val Asn Gly Val Ala Arg Ile His Ser Glu Ile Val 
     450                455                460
Lys Gln Ser Val Phe Lys Asp Phe Tyr Glu Leu Glu Pro Glu Lys Phe 
 465                470                475                480
Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Leu Leu Cys 
                 485                490                495
Asn Pro Gly Leu Ala Glu Ile Ile Val Glu Arg Ile Gly Glu Gly Phe 
             500                505                510
Leu Thr Asp Leu Ser Gln Leu Lys Lys Leu Leu Ser Leu Val Asp Asp 
         515                520                525
Glu Ala Phe Ile Arg Asp Val Ala Lys Val Lys Gln Glu Asn Lys Leu 
     530                535                540
Lys Phe Ser Ala Gln Leu Glu Lys Glu Tyr Lys Val Lys Ile Asn Pro 
 545                550                555                560
Cys Ser Met Phe Asp Val His Val Lys Arg Ile His Glu Tyr Lys Arg 
                 565                570                575
Gln Leu Leu Asn Cys Leu His Ile Ile Thr Leu Tyr Asn Arg Ile Lys 
             580                585                590
Lys Asp Pro Thr Lys Thr Phe Val Pro Arg Thr Val Met Ile Gly Gly 
         595                600                605
Lys Ala Ala Pro Gly Tyr His Met Ala Lys Met Ile Ile Lys Leu Val 
     610                615                620
Thr Ser Ile Gly Asp Val Val Asn His Asp Pro Val Val Gly Asp Arg 
 625                630                635                640
Leu Arg Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu Lys 
                 645                650                655
Val Ile Pro Ala Ala Asp Leu Ser Gln Gln Ile Ser Thr Ala Gly Thr 
             660                665                670
Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala Leu 
         675                680                685
Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu Ala 
     690                695                700
Gly Glu Glu Asn Leu Phe Ile Phe Gly Met Arg Val Glu Asp Val Glu 
 705                710                715                720
Ala Leu Asp Gln Lys Gly Tyr Asn Ala Gln Glu Phe Tyr Glu Arg Leu 
                 725                730                735
Pro Glu Leu Arg Gln Ala Val Asp Gln Ile Ser Ser Gly Phe Phe Ser 
             740                745                750
Pro Lys Asp Pro Asp Cys Phe Lys Asp Val Val Asn Met Leu Met Tyr 
         755                760                765
His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Ala Tyr Ile Gln Cys 
     770                775                780
Gln Ala Gln Val Asp His Leu Tyr Arg Asn Pro Lys Asp Trp Thr Lys 
 785                790                795                800
Lys Val Ile Arg Asn Ile Ala Cys Ser Gly Lys Phe Ser Ser Asp Arg 
                 805                810                815
Thr Ile Thr Glu Tyr Ala Arg Glu Ile Trp Gly Val Glu Pro Ser Asp 
             820                825                830
Leu Gln Ile Pro Pro Pro 
         835



<210> 4598
<211> 1972
<212> PRT
<213> Homo sapiens
<308> P35749
<400> 4598

Met Ala Gln Lys Gly Gln Leu Ser Asp Asp Glu Lys Phe Leu Phe Val 
  1               5                  10                  15
Asp Lys Asn Phe Ile Asn Ser Pro Val Ala Gln Ala Asp Trp Ala Ala 
             20                  25                  30
Lys Arg Leu Val Trp Val Pro Ser Glu Lys Gln Gly Phe Glu Ala Ala 
         35                  40                  45
Ser Ile Lys Glu Glu Lys Gly Asp Glu Val Val Val Glu Leu Val Glu 
     50                  55                  60
Asn Gly Lys Lys Val Thr Val Gly Lys Asp Asp Ile Gln Lys Met Asn 
 65                  70                  75                  80
Pro Pro Lys Phe Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu 
                 85                  90                  95
Asn Glu Ala Ser Val Leu His Asn Leu Arg Glu Arg Tyr Phe Ser Gly 
             100                105                110
Leu Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val Val Asn Pro Tyr 
         115                120                125
Lys His Leu Pro Ile Tyr Ser Glu Lys Ile Val Asp Met Tyr Lys Gly 
     130                135                140
Lys Lys Arg His Glu Met Pro Pro His Ile Tyr Ala Ile Ala Asp Thr 
 145                150                155                160
Ala Tyr Arg Ser Met Leu Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys 
                 165                170                175
Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile 
             180                185                190
Gln Tyr Leu Ala Val Val Ala Ser Ser His Lys Gly Lys Lys Asp Thr 
         195                200                205
Ser Ile Thr Gly Glu Leu Glu Lys Gln Leu Leu Gln Ala Asn Pro Ile 
     210                215                220
Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Lys Asn Asp Asn Ser Ser 
 225                230                235                240
Arg Phe Gly Lys Phe Ile Arg Ile Asn Phe Asp Val Thr Gly Tyr Ile 
                 245                250                255
Val Gly Ala Asn Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg Ala Ile 
             260                265                270
Arg Gln Ala Arg Asp Glu Arg Thr Phe His Ile Phe Tyr Tyr Met Ile 
         275                280                285
Ala Gly Ala Lys Glu Lys Met Arg Ser Asp Leu Leu Leu Glu Gly Phe 
     290                295                300
Asn Asn Tyr Thr Phe Leu Ser Asn Gly Phe Val Pro Ile Pro Ala Ala 
 305                310                315                320
Gln Asp Asp Glu Met Phe Gln Glu Thr Val Glu Ala Met Ala Ile Met 
                 325                330                335
Gly Phe Ser Glu Glu Glu Gln Leu Ser Ile Leu Lys Val Val Ser Ser 
             340                345                350
Val Leu Gln Leu Gly Asn Ile Val Phe Lys Lys Glu Arg Asn Thr Asp 
         355                360                365
Gln Ala Ser Met Pro Asp Asn Thr Ala Ala Gln Lys Val Cys His Leu 
     370                375                380
Met Gly Ile Asn Val Thr Asp Phe Thr Arg Ser Ile Leu Thr Pro Arg 
 385                390                395                400
Ile Lys Val Gly Arg Asp Val Val Gln Lys Ala Gln Thr Lys Glu Gln 
                 405                410                415
Ala Asp Phe Ala Val Glu Ala Leu Ala Lys Ala Thr Tyr Glu Arg Leu 
             420                425                430
Phe Arg Trp Ile Leu Thr Arg Val Asn Lys Ala Leu Asp Lys Thr His 
         435                440                445
Arg Gln Gly Ala Ser Phe Leu Gly Ile Leu Asp Ile Ala Gly Phe Glu 
     450                455                460
Ile Phe Glu Val Asn Ser Phe Glu Gln Leu Cys Ile Asn Tyr Thr Asn 
 465                470                475                480
Glu Lys Leu Gln Gln Leu Phe Asn His Thr Met Phe Ile Leu Glu Gln 
                 485                490                495
Glu Glu Tyr Gln Arg Glu Gly Ile Glu Trp Asn Phe Ile Asp Phe Gly 
             500                505                510
Leu Asp Leu Gln Pro Cys Ile Glu Leu Ile Glu Arg Pro Asn Asn Pro 
         515                520                525
Pro Gly Val Leu Ala Leu Leu Asp Glu Glu Cys Trp Phe Pro Lys Ala 
     530                535                540
Thr Asp Lys Ser Phe Val Glu Lys Leu Cys Thr Glu Gln Gly Ser His 
 545                550                555                560
Pro Lys Phe Gln Lys Pro Lys Gln Leu Lys Asp Lys Thr Glu Phe Ser 
                 565                570                575
Ile Ile His Tyr Ala Gly Lys Val Asp Tyr Asn Ala Ser Ala Trp Leu 
             580                585                590
Thr Lys Asn Met Asp Pro Leu Asn Asp Asn Val Thr Ser Leu Leu Asn 
         595                600                605
Ala Ser Ser Asp Lys Phe Val Ala Asp Leu Trp Lys Asp Val Asp Arg 
     610                615                620
Ile Val Gly Leu Asp Gln Met Ala Lys Met Thr Glu Ser Ser Leu Pro 
 625                630                635                640
Ser Ala Ser Lys Thr Lys Lys Gly Met Phe Arg Thr Val Gly Gln Leu 
                 645                650                655
Tyr Lys Glu Gln Leu Gly Lys Leu Met Thr Thr Leu Arg Asn Thr Thr 
             660                665                670
Pro Asn Phe Val Arg Cys Ile Ile Pro Asn His Glu Lys Arg Ser Gly 
         675                680                685
Lys Leu Asp Ala Phe Leu Val Leu Glu Gln Leu Arg Cys Asn Gly Val 
     690                695                700
Leu Glu Gly Ile Arg Ile Cys Arg Gln Gly Phe Pro Asn Arg Ile Val 
 705                710                715                720
Phe Gln Glu Phe Arg Gln Arg Tyr Glu Ile Leu Ala Ala Asn Ala Ile 
                 725                730                735
Pro Lys Gly Phe Met Asp Gly Lys Gln Ala Cys Ile Leu Met Ile Lys 
             740                745                750
Ala Leu Glu Leu Asp Pro Asn Leu Tyr Arg Ile Gly Gln Ser Lys Ile 
         755                760                765
Phe Phe Arg Thr Gly Val Leu Ala His Leu Glu Glu Glu Arg Asp Leu 
     770                775                780
Lys Ile Thr Asp Val Ile Met Ala Phe Gln Ala Met Cys Arg Gly Tyr 
 785                790                795                800
Leu Ala Arg Lys Ala Phe Ala Lys Arg Gln Gln Gln Leu Thr Ala Met 
                 805                810                815
Lys Val Ile Gln Arg Asn Cys Ala Ala Tyr Leu Lys Leu Arg Asn Trp 
             820                825                830
Gln Trp Trp Arg Leu Phe Thr Lys Val Lys Pro Leu Leu Gln Val Thr 
         835                840                845
Arg Gln Glu Glu Glu Met Gln Ala Lys Glu Asp Glu Leu Gln Lys Thr 
     850                855                860
Lys Glu Arg Gln Gln Lys Ala Glu Asn Glu Leu Lys Glu Leu Glu Gln 
 865                870                875                880
Lys His Ser Gln Leu Thr Glu Glu Lys Asn Leu Leu Gln Glu Gln Leu 
                 885                890                895
Gln Ala Glu Thr Glu Leu Tyr Ala Glu Ala Glu Glu Met Arg Val Arg 
             900                905                910
Leu Ala Ala Lys Lys Gln Glu Leu Glu Glu Ile Leu His Glu Met Glu 
         915                920                925
Ala Arg Leu Glu Glu Glu Glu Asp Arg Gly Gln Gln Leu Gln Ala Glu 
     930                935                940
Arg Lys Lys Met Ala Gln Gln Met Leu Asp Leu Glu Glu Gln Leu Glu 
 945                950                955                960
Glu Glu Glu Ala Ala Arg Gln Lys Leu Gln Leu Glu Lys Val Thr Ala 
                 965                970                975
Glu Ala Lys Ile Lys Lys Leu Glu Asp Glu Ile Leu Val Met Asp Asp 
             980                985                990
Gln Asn Asn Lys Leu Ser Lys Glu Arg Lys Leu Leu Glu Glu Arg Ile 
         995                1000                1005
Ser Asp Leu Thr Thr Asn Leu Ala Glu Glu Glu Glu Lys Ala Lys Asn 
     1010                1015                1020
Leu Thr Lys Leu Lys Asn Lys His Glu Ser Met Ile Ser Glu Leu Glu 
 1025                1030                1035                1040
Val Arg Leu Lys Lys Glu Glu Lys Ser Arg Gln Glu Leu Glu Lys Leu 
                 1045                1050                1055
Lys Arg Lys Leu Glu Gly Asp Ala Ser Asp Phe His Glu Gln Ile Ala 
             1060                1065                1070
Asp Leu Gln Ala Gln Ile Ala Glu Leu Lys Met Gln Leu Ala Lys Lys 
         1075                1080                1085
Glu Glu Glu Leu Gln Ala Ala Leu Ala Arg Leu Asp Asp Glu Ile Ala 
     1090                1095                1100
Gln Lys Asn Asn Ala Leu Lys Lys Ile Arg Glu Leu Glu Gly His Ile 
 1105                1110                1115                1120
Ser Asp Leu Gln Glu Asp Leu Asp Ser Glu Arg Ala Ala Arg Asn Lys 
                 1125                1130                1135
Ala Glu Lys Gln Lys Arg Asp Leu Gly Glu Glu Leu Glu Ala Leu Lys 
             1140                1145                1150
Thr Glu Leu Glu Asp Thr Leu Asp Ser Thr Ala Thr Gln Gln Glu Leu 
         1155                1160                1165
Arg Ala Lys Arg Glu Gln Glu Val Thr Val Leu Lys Lys Ala Leu Asp 
     1170                1175                1180
Glu Glu Thr Arg Ser His Glu Ala Gln Val Gln Glu Met Arg Gln Lys 
 1185                1190                1195                1200
His Ala Gln Ala Val Glu Glu Leu Thr Glu Gln Leu Glu Gln Phe Lys 
                 1205                1210                1215
Arg Ala Lys Ala Asn Leu Asp Lys Asn Lys Gln Thr Leu Glu Lys Glu 
             1220                1225                1230
Asn Ala Asp Leu Ala Gly Glu Leu Arg Val Leu Gly Gln Ala Lys Gln 
         1235                1240                1245
Glu Val Glu His Lys Lys Lys Lys Leu Glu Ala Gln Val Gln Glu Leu 
     1250                1255                1260
Gln Ser Lys Cys Ser Asp Gly Glu Arg Ala Arg Ala Glu Leu Asn Asp 
 1265                1270                1275                1280
Lys Val His Lys Leu Gln Asn Glu Val Glu Ser Val Thr Gly Met Leu 
                 1285                1290                1295
Asn Glu Ala Glu Gly Lys Ala Ile Lys Leu Ala Lys Asp Val Ala Ser 
             1300                1305                1310
Leu Ser Ser Gln Leu Gln Asp Thr Gln Glu Leu Leu Gln Glu Glu Thr 
         1315                1320                1325
Arg Gln Lys Leu Asn Val Ser Thr Lys Leu Arg Gln Leu Glu Glu Glu 
     1330                1335                1340
Arg Asn Ser Leu Gln Asp Gln Leu Asp Glu Glu Met Glu Ala Lys Gln 
 1345                1350                1355                1360
Asn Leu Glu Arg His Ile Ser Thr Leu Asn Ile Gln Leu Ser Asp Ser 
                 1365                1370                1375
Lys Lys Lys Leu Gln Asp Phe Ala Ser Thr Val Glu Ala Leu Glu Glu 
             1380                1385                1390
Gly Lys Lys Arg Phe Gln Lys Glu Ile Glu Asn Leu Thr Gln Gln Tyr 
         1395                1400                1405
Glu Glu Lys Ala Ala Ala Tyr Asp Lys Leu Glu Lys Thr Lys Asn Arg 
     1410                1415                1420
Leu Gln Gln Glu Leu Asp Asp Leu Val Val Asp Leu Asp Asn Gln Arg 
 1425                1430                1435                1440
Gln Leu Val Ser Asn Leu Glu Lys Lys Gln Arg Lys Phe Asp Gln Leu 
                 1445                1450                1455
Leu Ala Glu Glu Lys Asn Ile Ser Ser Lys Tyr Ala Asp Glu Arg Asp 
             1460                1465                1470
Arg Ala Glu Ala Glu Ala Arg Glu Lys Glu Thr Lys Ala Leu Ser Leu 
         1475                1480                1485
Ala Arg Ala Leu Glu Glu Ala Leu Glu Ala Lys Glu Glu Leu Glu Arg 
     1490                1495                1500
Thr Asn Lys Met Leu Lys Ala Glu Met Glu Asp Leu Val Ser Ser Lys 
 1505                1510                1515                1520
Asp Asp Val Gly Lys Asn Val His Glu Leu Glu Lys Ser Lys Arg Ala 
                 1525                1530                1535
Leu Glu Thr Gln Met Glu Glu Met Lys Thr Gln Leu Glu Glu Leu Glu 
             1540                1545                1550
Asp Glu Leu Gln Ala Thr Glu Asp Ala Lys Leu Arg Leu Glu Val Asn 
         1555                1560                1565
Met Gln Ala Leu Lys Gly Gln Phe Glu Arg Asp Leu Gln Ala Arg Asp 
     1570                1575                1580
Glu Gln Asn Glu Glu Lys Arg Arg Gln Leu Gln Arg Gln Leu His Glu 
 1585                1590                1595                1600
Tyr Glu Thr Glu Leu Glu Asp Glu Arg Lys Gln Arg Ala Leu Ala Ala 
                 1605                1610                1615
Ala Ala Lys Lys Lys Leu Glu Gly Asp Leu Lys Asp Leu Glu Leu Gln 
             1620                1625                1630
Ala Asp Ser Ala Ile Lys Gly Arg Glu Glu Ala Ile Lys Gln Leu Arg 
         1635                1640                1645
Lys Leu Gln Ala Gln Met Lys Asp Phe Gln Arg Glu Leu Glu Asp Ala 
     1650                1655                1660
Arg Ala Ser Arg Asp Glu Ile Phe Ala Thr Ala Lys Glu Asn Glu Lys 
 1665                1670                1675                1680
Lys Ala Lys Ser Leu Glu Ala Asp Leu Met Gln Leu Gln Glu Asp Leu 
                 1685                1690                1695
Ala Ala Ala Glu Arg Ala Arg Lys Gln Ala Asp Leu Glu Lys Glu Glu 
             1700                1705                1710
Leu Ala Glu Glu Leu Ala Ser Ser Leu Ser Gly Arg Asn Ala Leu Gln 
         1715                1720                1725
Asp Glu Lys Arg Arg Leu Glu Ala Arg Ile Ala Gln Leu Glu Glu Glu 
     1730                1735                1740
Leu Glu Glu Glu Gln Gly Asn Met Glu Ala Met Ser Asp Arg Val Arg 
 1745                1750                1755                1760
Lys Ala Thr Gln Gln Ala Glu Gln Leu Ser Asn Glu Leu Ala Thr Glu 
                 1765                1770                1775
Arg Ser Thr Ala Gln Lys Asn Glu Ser Ala Arg Gln Gln Leu Glu Arg 
             1780                1785                1790
Gln Asn Lys Glu Leu Arg Ser Lys Leu His Glu Met Glu Gly Ala Val 
         1795                1800                1805
Lys Ser Lys Phe Lys Ser Thr Ile Ala Ala Leu Glu Ala Lys Ile Ala 
     1810                1815                1820
Gln Leu Glu Glu Gln Val Glu Gln Glu Ala Arg Glu Lys Gln Ala Ala 
 1825                1830                1835                1840
Thr Lys Ser Leu Lys Gln Lys Asp Lys Lys Leu Lys Glu Ile Leu Leu 
                 1845                1850                1855
Gln Val Glu Asp Glu Arg Lys Met Ala Glu Gln Tyr Lys Glu Gln Ala 
             1860                1865                1870
Glu Lys Gly Asn Ala Arg Val Lys Gln Leu Lys Arg Gln Leu Glu Glu 
         1875                1880                1885
Ala Glu Glu Glu Ser Gln Arg Ile Asn Ala Asn Arg Arg Lys Leu Gln 
     1890                1895                1900
Arg Glu Leu Asp Glu Ala Thr Glu Ser Asn Glu Ala Met Gly Arg Glu 
 1905                1910                1915                1920
Val Asn Ala Leu Lys Ser Lys Leu Arg Arg Gly Asn Glu Thr Ser Phe 
                 1925                1930                1935
Val Pro Ser Arg Arg Ser Gly Gly Arg Arg Val Ile Glu Asn Ala Asp 
             1940                1945                1950
Gly Ser Glu Glu Glu Thr Asp Thr Arg Asp Ala Asp Phe Asn Gly Thr 
         1955                1960                1965
Lys Ala Ser Glu 
     1970



<210> 4599
<211> 693
<212> DNA
<213> Rattus norvegicus
<308> AA800190
<400> 4599

atgggtata  aagtttaat  catttctct  acaaggagg  aacagtaaa  agtagaggg  60
tgatcatgt  ttatggctt  aagggacct  atgcacagg  cagcagatg  ccagcccca  120
aacctgccc  cccaccccc  aagctacca  agtggttcc  gtgaattga  tgctgaaaa  180
agacacctc  cagtaaaca  tgccagggt  gaggaaagt  aggcgtttt  ctgcccatc  240
cgaaccaga  acagcaatg  aaggtggtg  atctctgga  ggagtttta  gtagttctc  300
gacaaccct  ctctgccct  agggaggag  atggctcct  tagtgggtg  gcttaaccg  360
tctttctca  tatgctgct  tagcagagt  ggaaccagg  cctactgca  gactagcag  420
tgagtcagc  agggcagaa  tatccagac  gaccaagta  aaggtttac  tgcaaaaaa  480
ggaaggctt  agctagttt  aattcctca  gaagtgtta  ttcctgttg  aaaagcaaa  540
gactaagcc  accgtctat  aaattgcca  tccttaacc  aggcctcaa  tatgggata  600
aggtctctc  ttagtctcc  cttcagggt  ctggggttc  acatgacac  cacagggtt  660
tacaggtgg  tacagaggc  tggccccat  tgg  693



<210> 4600
<211> 838
<212> PRT
<213> Rattus norvegicus
<308> AAA41252
<400> 4600

Met Ala Lys Pro Leu Thr Asp Ser Glu Arg Gln Lys Gln Ile Ser Val 
  1               5                  10                  15
Arg Gly Ile Ala Gly Leu Gly Asp Val Ala Glu Val Arg Lys Ser Phe 
             20                  25                  30
Asn Arg His Leu His Phe Thr Leu Val Lys Asp Arg Asn Val Ala Thr 
         35                  40                  45
Pro Arg Asp Tyr Phe Phe Ala Leu Ala His Thr Val Arg Asp His Leu 
     50                  55                  60
Val Gly Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Glu Arg Asp Pro 
 65                  70                  75                  80
Lys Arg Ile Tyr Tyr Leu Ser Leu Glu Phe Tyr Met Gly Arg Thr Leu 
                 85                  90                  95
Gln Asn Thr Met Val Asn Leu Gly Leu Gln Thr Ala Cys Asp Glu Ala 
             100                105                110
Thr Tyr Gln Leu Gly Leu Asp Leu Glu Glu Leu Glu Glu Ile Glu Glu 
         115                120                125
Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe 
     130                135                140
Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile 
 145                150                155                160
Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile Val Asn Gly Trp Gln 
                 165                170                175
Val Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys 
             180                185                190
Ala Arg Pro Glu Tyr Met Leu Pro Val His Phe Tyr Gly Arg Val Glu 
         195                200                205
His Thr Pro Asn Gly Val Leu Trp Leu Asp Thr Gln Val Val Leu Ala 
     210                215                220
Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Lys Asn Asn Thr Val Asn 
 225                230                235                240
Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Asn Asp Phe Lys Leu Lys 
                 245                250                255
Asp Phe Asn Val Gly Asp Tyr Ile Glu Ala Val Leu Asp Arg Asn Leu 
             260                265                270
Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Asn Phe Phe Glu 
         275                280                285
Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr 
     290                295                300
Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser Lys Phe Gly Cys Arg 
 305                310                315                320
Asp Pro Val Arg Thr Cys Phe Glu Thr Phe Pro Asp Lys Val Ala Ile 
                 325                330                335
Gln Leu Asn Asp Thr His Pro Ala Leu Ser Ile Pro Glu Leu Met Arg 
             340                345                350
Ile Leu Val Asp Val Glu Lys Val Asp Trp Asp Lys Ala Trp Glu Ile 
         355                360                365
Thr Lys Lys Thr Cys Ala Tyr Thr Asn His Thr Val Leu Pro Glu Ala 
     370                375                380
Leu Glu Arg Trp Pro Val Ser Met Phe Glu Lys Leu Leu Pro Arg His 
 385                390                395                400
Leu Glu Ile Ile Tyr Ala Ile Asn Gln Arg His Leu Asp His Val Ala 
                 405                410                415
Ala Leu Phe Pro Gly Asp Val Asp Arg Leu Arg Arg Met Ser Val Ile 
             420                425                430
Glu Glu Gly Asp Cys Lys Arg Ile Asn Met Ala His Leu Cys Val Ile 
         435                440                445
Gly Ser His Ala Val Asn Gly Val Ala Arg Ile His Ser Glu Ile Val 
     450                455                460
Lys Gln Ser Val Phe Lys Asp Phe Tyr Glu Leu Glu Pro Glu Lys Phe 
 465                470                475                480
Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Leu Leu Cys 
                 485                490                495
Asn Pro Gly Leu Ala Glu Ile Ile Val Glu Arg Ile Gly Glu Gly Phe 
             500                505                510
Leu Thr Asp Leu Ser Gln Leu Lys Lys Leu Leu Ser Leu Val Asp Asp 
         515                520                525
Glu Ala Phe Ile Arg Asp Val Ala Lys Val Lys Gln Glu Asn Lys Leu 
     530                535                540
Lys Phe Ser Ala Gln Leu Glu Lys Glu Tyr Lys Val Lys Ile Asn Pro 
 545                550                555                560
Cys Ser Met Phe Asp Val His Val Lys Arg Ile His Glu Tyr Lys Arg 
                 565                570                575
Gln Leu Leu Asn Cys Leu His Ile Ile Thr Leu Tyr Asn Arg Ile Lys 
             580                585                590
Lys Asp Pro Thr Lys Thr Phe Val Pro Arg Thr Val Met Ile Gly Gly 
         595                600                605
Lys Ala Ala Pro Gly Tyr His Met Ala Lys Met Ile Ile Lys Leu Val 
     610                615                620
Thr Ser Ile Gly Asp Val Val Asn His Asp Pro Val Val Gly Asp Arg 
 625                630                635                640
Leu Arg Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu Lys 
                 645                650                655
Val Ile Pro Ala Ala Asp Leu Ser Gln Gln Ile Ser Thr Ala Gly Thr 
             660                665                670
Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala Leu 
         675                680                685
Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu Ala 
     690                695                700
Gly Glu Glu Asn Leu Phe Ile Phe Gly Met Arg Val Glu Asp Val Glu 
 705                710                715                720
Ala Leu Asp Gln Lys Gly Tyr Asn Ala Gln Glu Phe Tyr Glu Arg Leu 
                 725                730                735
Pro Glu Leu Arg Gln Ala Val Asp Gln Ile Ser Ser Gly Phe Phe Ser 
             740                745                750
Pro Lys Asp Pro Asp Cys Phe Lys Asp Val Val Asn Met Leu Met Tyr 
         755                760                765
His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Ala Tyr Ile Gln Cys 
     770                775                780
Gln Ala Gln Val Asp His Leu Tyr Arg Asn Pro Lys Asp Trp Thr Lys 
 785                790                795                800
Lys Val Ile Arg Asn Ile Ala Cys Ser Gly Lys Phe Ser Ser Asp Arg 
                 805                810                815
Thr Ile Thr Glu Tyr Ala Arg Glu Ile Trp Gly Val Glu Pro Ser Asp 
             820                825                830
Leu Gln Ile Pro Pro Pro 
         835



<210> 4602
<211> 1972
<212> PRT
<213> Homo sapiens
<308> P35749
<400> 4602

Met Ala Gln Lys Gly Gln Leu Ser Asp Asp Glu Lys Phe Leu Phe Val 
  1               5                  10                  15
Asp Lys Asn Phe Ile Asn Ser Pro Val Ala Gln Ala Asp Trp Ala Ala 
             20                  25                  30
Lys Arg Leu Val Trp Val Pro Ser Glu Lys Gln Gly Phe Glu Ala Ala 
         35                  40                  45
Ser Ile Lys Glu Glu Lys Gly Asp Glu Val Val Val Glu Leu Val Glu 
     50                  55                  60
Asn Gly Lys Lys Val Thr Val Gly Lys Asp Asp Ile Gln Lys Met Asn 
 65                  70                  75                  80
Pro Pro Lys Phe Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu 
                 85                  90                  95
Asn Glu Ala Ser Val Leu His Asn Leu Arg Glu Arg Tyr Phe Ser Gly 
             100                105                110
Leu Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val Val Asn Pro Tyr 
         115                120                125
Lys His Leu Pro Ile Tyr Ser Glu Lys Ile Val Asp Met Tyr Lys Gly 
     130                135                140
Lys Lys Arg His Glu Met Pro Pro His Ile Tyr Ala Ile Ala Asp Thr 
 145                150                155                160
Ala Tyr Arg Ser Met Leu Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys 
                 165                170                175
Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile 
             180                185                190
Gln Tyr Leu Ala Val Val Ala Ser Ser His Lys Gly Lys Lys Asp Thr 
         195                200                205
Ser Ile Thr Gly Glu Leu Glu Lys Gln Leu Leu Gln Ala Asn Pro Ile 
     210                215                220
Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Lys Asn Asp Asn Ser Ser 
 225                230                235                240
Arg Phe Gly Lys Phe Ile Arg Ile Asn Phe Asp Val Thr Gly Tyr Ile 
                 245                250                255
Val Gly Ala Asn Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg Ala Ile 
             260                265                270
Arg Gln Ala Arg Asp Glu Arg Thr Phe His Ile Phe Tyr Tyr Met Ile 
         275                280                285
Ala Gly Ala Lys Glu Lys Met Arg Ser Asp Leu Leu Leu Glu Gly Phe 
     290                295                300
Asn Asn Tyr Thr Phe Leu Ser Asn Gly Phe Val Pro Ile Pro Ala Ala 
 305                310                315                320
Gln Asp Asp Glu Met Phe Gln Glu Thr Val Glu Ala Met Ala Ile Met 
                 325                330                335
Gly Phe Ser Glu Glu Glu Gln Leu Ser Ile Leu Lys Val Val Ser Ser 
             340                345                350
Val Leu Gln Leu Gly Asn Ile Val Phe Lys Lys Glu Arg Asn Thr Asp 
         355                360                365
Gln Ala Ser Met Pro Asp Asn Thr Ala Ala Gln Lys Val Cys His Leu 
     370                375                380
Met Gly Ile Asn Val Thr Asp Phe Thr Arg Ser Ile Leu Thr Pro Arg 
 385                390                395                400
Ile Lys Val Gly Arg Asp Val Val Gln Lys Ala Gln Thr Lys Glu Gln 
                 405                410                415
Ala Asp Phe Ala Val Glu Ala Leu Ala Lys Ala Thr Tyr Glu Arg Leu 
             420                425                430
Phe Arg Trp Ile Leu Thr Arg Val Asn Lys Ala Leu Asp Lys Thr His 
         435                440                445
Arg Gln Gly Ala Ser Phe Leu Gly Ile Leu Asp Ile Ala Gly Phe Glu 
     450                455                460
Ile Phe Glu Val Asn Ser Phe Glu Gln Leu Cys Ile Asn Tyr Thr Asn 
 465                470                475                480
Glu Lys Leu Gln Gln Leu Phe Asn His Thr Met Phe Ile Leu Glu Gln 
                 485                490                495
Glu Glu Tyr Gln Arg Glu Gly Ile Glu Trp Asn Phe Ile Asp Phe Gly 
             500                505                510
Leu Asp Leu Gln Pro Cys Ile Glu Leu Ile Glu Arg Pro Asn Asn Pro 
         515                520                525
Pro Gly Val Leu Ala Leu Leu Asp Glu Glu Cys Trp Phe Pro Lys Ala 
     530                535                540
Thr Asp Lys Ser Phe Val Glu Lys Leu Cys Thr Glu Gln Gly Ser His 
 545                550                555                560
Pro Lys Phe Gln Lys Pro Lys Gln Leu Lys Asp Lys Thr Glu Phe Ser 
                 565                570                575
Ile Ile His Tyr Ala Gly Lys Val Asp Tyr Asn Ala Ser Ala Trp Leu 
             580                585                590
Thr Lys Asn Met Asp Pro Leu Asn Asp Asn Val Thr Ser Leu Leu Asn 
         595                600                605
Ala Ser Ser Asp Lys Phe Val Ala Asp Leu Trp Lys Asp Val Asp Arg 
     610                615                620
Ile Val Gly Leu Asp Gln Met Ala Lys Met Thr Glu Ser Ser Leu Pro 
 625                630                635                640
Ser Ala Ser Lys Thr Lys Lys Gly Met Phe Arg Thr Val Gly Gln Leu 
                 645                650                655
Tyr Lys Glu Gln Leu Gly Lys Leu Met Thr Thr Leu Arg Asn Thr Thr 
             660                665                670
Pro Asn Phe Val Arg Cys Ile Ile Pro Asn His Glu Lys Arg Ser Gly 
         675                680                685
Lys Leu Asp Ala Phe Leu Val Leu Glu Gln Leu Arg Cys Asn Gly Val 
     690                695                700
Leu Glu Gly Ile Arg Ile Cys Arg Gln Gly Phe Pro Asn Arg Ile Val 
 705                710                715                720
Phe Gln Glu Phe Arg Gln Arg Tyr Glu Ile Leu Ala Ala Asn Ala Ile 
                 725                730                735
Pro Lys Gly Phe Met Asp Gly Lys Gln Ala Cys Ile Leu Met Ile Lys 
             740                745                750
Ala Leu Glu Leu Asp Pro Asn Leu Tyr Arg Ile Gly Gln Ser Lys Ile 
         755                760                765
Phe Phe Arg Thr Gly Val Leu Ala His Leu Glu Glu Glu Arg Asp Leu 
     770                775                780
Lys Ile Thr Asp Val Ile Met Ala Phe Gln Ala Met Cys Arg Gly Tyr 
 785                790                795                800
Leu Ala Arg Lys Ala Phe Ala Lys Arg Gln Gln Gln Leu Thr Ala Met 
                 805                810                815
Lys Val Ile Gln Arg Asn Cys Ala Ala Tyr Leu Lys Leu Arg Asn Trp 
             820                825                830
Gln Trp Trp Arg Leu Phe Thr Lys Val Lys Pro Leu Leu Gln Val Thr 
         835                840                845
Arg Gln Glu Glu Glu Met Gln Ala Lys Glu Asp Glu Leu Gln Lys Thr 
     850                855                860
Lys Glu Arg Gln Gln Lys Ala Glu Asn Glu Leu Lys Glu Leu Glu Gln 
 865                870                875                880
Lys His Ser Gln Leu Thr Glu Glu Lys Asn Leu Leu Gln Glu Gln Leu 
                 885                890                895
Gln Ala Glu Thr Glu Leu Tyr Ala Glu Ala Glu Glu Met Arg Val Arg 
             900                905                910
Leu Ala Ala Lys Lys Gln Glu Leu Glu Glu Ile Leu His Glu Met Glu 
         915                920                925
Ala Arg Leu Glu Glu Glu Glu Asp Arg Gly Gln Gln Leu Gln Ala Glu 
     930                935                940
Arg Lys Lys Met Ala Gln Gln Met Leu Asp Leu Glu Glu Gln Leu Glu 
 945                950                955                960
Glu Glu Glu Ala Ala Arg Gln Lys Leu Gln Leu Glu Lys Val Thr Ala 
                 965                970                975
Glu Ala Lys Ile Lys Lys Leu Glu Asp Glu Ile Leu Val Met Asp Asp 
             980                985                990
Gln Asn Asn Lys Leu Ser Lys Glu Arg Lys Leu Leu Glu Glu Arg Ile 
         995                1000                1005
Ser Asp Leu Thr Thr Asn Leu Ala Glu Glu Glu Glu Lys Ala Lys Asn 
     1010                1015                1020
Leu Thr Lys Leu Lys Asn Lys His Glu Ser Met Ile Ser Glu Leu Glu 
 1025                1030                1035                1040
Val Arg Leu Lys Lys Glu Glu Lys Ser Arg Gln Glu Leu Glu Lys Leu 
                 1045                1050                1055
Lys Arg Lys Leu Glu Gly Asp Ala Ser Asp Phe His Glu Gln Ile Ala 
             1060                1065                1070
Asp Leu Gln Ala Gln Ile Ala Glu Leu Lys Met Gln Leu Ala Lys Lys 
         1075                1080                1085
Glu Glu Glu Leu Gln Ala Ala Leu Ala Arg Leu Asp Asp Glu Ile Ala 
     1090                1095                1100
Gln Lys Asn Asn Ala Leu Lys Lys Ile Arg Glu Leu Glu Gly His Ile 
 1105                1110                1115                1120
Ser Asp Leu Gln Glu Asp Leu Asp Ser Glu Arg Ala Ala Arg Asn Lys 
                 1125                1130                1135
Ala Glu Lys Gln Lys Arg Asp Leu Gly Glu Glu Leu Glu Ala Leu Lys 
             1140                1145                1150
Thr Glu Leu Glu Asp Thr Leu Asp Ser Thr Ala Thr Gln Gln Glu Leu 
         1155                1160                1165
Arg Ala Lys Arg Glu Gln Glu Val Thr Val Leu Lys Lys Ala Leu Asp 
     1170                1175                1180
Glu Glu Thr Arg Ser His Glu Ala Gln Val Gln Glu Met Arg Gln Lys 
 1185                1190                1195                1200
His Ala Gln Ala Val Glu Glu Leu Thr Glu Gln Leu Glu Gln Phe Lys 
                 1205                1210                1215
Arg Ala Lys Ala Asn Leu Asp Lys Asn Lys Gln Thr Leu Glu Lys Glu 
             1220                1225                1230
Asn Ala Asp Leu Ala Gly Glu Leu Arg Val Leu Gly Gln Ala Lys Gln 
         1235                1240                1245
Glu Val Glu His Lys Lys Lys Lys Leu Glu Ala Gln Val Gln Glu Leu 
     1250                1255                1260
Gln Ser Lys Cys Ser Asp Gly Glu Arg Ala Arg Ala Glu Leu Asn Asp 
 1265                1270                1275                1280
Lys Val His Lys Leu Gln Asn Glu Val Glu Ser Val Thr Gly Met Leu 
                 1285                1290                1295
Asn Glu Ala Glu Gly Lys Ala Ile Lys Leu Ala Lys Asp Val Ala Ser 
             1300                1305                1310
Leu Ser Ser Gln Leu Gln Asp Thr Gln Glu Leu Leu Gln Glu Glu Thr 
         1315                1320                1325
Arg Gln Lys Leu Asn Val Ser Thr Lys Leu Arg Gln Leu Glu Glu Glu 
     1330                1335                1340
Arg Asn Ser Leu Gln Asp Gln Leu Asp Glu Glu Met Glu Ala Lys Gln 
 1345                1350                1355                1360
Asn Leu Glu Arg His Ile Ser Thr Leu Asn Ile Gln Leu Ser Asp Ser 
                 1365                1370                1375
Lys Lys Lys Leu Gln Asp Phe Ala Ser Thr Val Glu Ala Leu Glu Glu 
             1380                1385                1390
Gly Lys Lys Arg Phe Gln Lys Glu Ile Glu Asn Leu Thr Gln Gln Tyr 
         1395                1400                1405
Glu Glu Lys Ala Ala Ala Tyr Asp Lys Leu Glu Lys Thr Lys Asn Arg 
     1410                1415                1420
Leu Gln Gln Glu Leu Asp Asp Leu Val Val Asp Leu Asp Asn Gln Arg 
 1425                1430                1435                1440
Gln Leu Val Ser Asn Leu Glu Lys Lys Gln Arg Lys Phe Asp Gln Leu 
                 1445                1450                1455
Leu Ala Glu Glu Lys Asn Ile Ser Ser Lys Tyr Ala Asp Glu Arg Asp 
             1460                1465                1470
Arg Ala Glu Ala Glu Ala Arg Glu Lys Glu Thr Lys Ala Leu Ser Leu 
         1475                1480                1485
Ala Arg Ala Leu Glu Glu Ala Leu Glu Ala Lys Glu Glu Leu Glu Arg 
     1490                1495                1500
Thr Asn Lys Met Leu Lys Ala Glu Met Glu Asp Leu Val Ser Ser Lys 
 1505                1510                1515                1520
Asp Asp Val Gly Lys Asn Val His Glu Leu Glu Lys Ser Lys Arg Ala 
                 1525                1530                1535
Leu Glu Thr Gln Met Glu Glu Met Lys Thr Gln Leu Glu Glu Leu Glu 
             1540                1545                1550
Asp Glu Leu Gln Ala Thr Glu Asp Ala Lys Leu Arg Leu Glu Val Asn 
         1555                1560                1565
Met Gln Ala Leu Lys Gly Gln Phe Glu Arg Asp Leu Gln Ala Arg Asp 
     1570                1575                1580
Glu Gln Asn Glu Glu Lys Arg Arg Gln Leu Gln Arg Gln Leu His Glu 
 1585                1590                1595                1600
Tyr Glu Thr Glu Leu Glu Asp Glu Arg Lys Gln Arg Ala Leu Ala Ala 
                 1605                1610                1615
Ala Ala Lys Lys Lys Leu Glu Gly Asp Leu Lys Asp Leu Glu Leu Gln 
             1620                1625                1630
Ala Asp Ser Ala Ile Lys Gly Arg Glu Glu Ala Ile Lys Gln Leu Arg 
         1635                1640                1645
Lys Leu Gln Ala Gln Met Lys Asp Phe Gln Arg Glu Leu Glu Asp Ala 
     1650                1655                1660
Arg Ala Ser Arg Asp Glu Ile Phe Ala Thr Ala Lys Glu Asn Glu Lys 
 1665                1670                1675                1680
Lys Ala Lys Ser Leu Glu Ala Asp Leu Met Gln Leu Gln Glu Asp Leu 
                 1685                1690                1695
Ala Ala Ala Glu Arg Ala Arg Lys Gln Ala Asp Leu Glu Lys Glu Glu 
             1700                1705                1710
Leu Ala Glu Glu Leu Ala Ser Ser Leu Ser Gly Arg Asn Ala Leu Gln 
         1715                1720                1725
Asp Glu Lys Arg Arg Leu Glu Ala Arg Ile Ala Gln Leu Glu Glu Glu 
     1730                1735                1740
Leu Glu Glu Glu Gln Gly Asn Met Glu Ala Met Ser Asp Arg Val Arg 
 1745                1750                1755                1760
Lys Ala Thr Gln Gln Ala Glu Gln Leu Ser Asn Glu Leu Ala Thr Glu 
                 1765                1770                1775
Arg Ser Thr Ala Gln Lys Asn Glu Ser Ala Arg Gln Gln Leu Glu Arg 
             1780                1785                1790
Gln Asn Lys Glu Leu Arg Ser Lys Leu His Glu Met Glu Gly Ala Val 
         1795                1800                1805
Lys Ser Lys Phe Lys Ser Thr Ile Ala Ala Leu Glu Ala Lys Ile Ala 
     1810                1815                1820
Gln Leu Glu Glu Gln Val Glu Gln Glu Ala Arg Glu Lys Gln Ala Ala 
 1825                1830                1835                1840
Thr Lys Ser Leu Lys Gln Lys Asp Lys Lys Leu Lys Glu Ile Leu Leu 
                 1845                1850                1855
Gln Val Glu Asp Glu Arg Lys Met Ala Glu Gln Tyr Lys Glu Gln Ala 
             1860                1865                1870
Glu Lys Gly Asn Ala Arg Val Lys Gln Leu Lys Arg Gln Leu Glu Glu 
         1875                1880                1885
Ala Glu Glu Glu Ser Gln Arg Ile Asn Ala Asn Arg Arg Lys Leu Gln 
     1890                1895                1900
Arg Glu Leu Asp Glu Ala Thr Glu Ser Asn Glu Ala Met Gly Arg Glu 
 1905                1910                1915                1920
Val Asn Ala Leu Lys Ser Lys Leu Arg Arg Gly Asn Glu Thr Ser Phe 
                 1925                1930                1935
Val Pro Ser Arg Arg Ser Gly Gly Arg Arg Val Ile Glu Asn Ala Asp 
             1940                1945                1950
Gly Ser Glu Glu Glu Thr Asp Thr Arg Asp Ala Asp Phe Asn Gly Thr 
         1955                1960                1965
Lys Ala Ser Glu 
     1970



<210> 4603
<211> 556
<212> DNA
<213> Rattus norvegicus
<308> AA800198
<400> 4603

ggaaacaga  acggtgctc  ttatttgca  tgttcagaa  actgtacaa  gggagtaaa  60
atcctattc  cactttgct  agaaagacc  aaaggtgaa  gttccctat  atacatggg  120
ttcaaaagg  gggtcaggg  ggaaacagg  gagtgacct  cctctggcc  ccgggagag  180
gcttgggca  ccacactat  caaaggaac  tgccccagt  gaaccagcg  ggggagaga  240
tgctcctct  tggcctaac  tcgggctct  tgacctgcc  gccactctg  gctgaggag  300
cagtgcccg  agctgtccc  actactgcc  tgtctgggc  gggatcctt  gcactgtgg  360
gaccactga  cgcatgtgg  agtggcctc  tgaccattc  cacgcaagc  acacaccag  420
cactgtccc  gcccaatct  cacaagaat  caagttgag  tttaaggaa  aacctctct  480
aaagcttcc  cacaccact  agggaagtg  caaagtaaa  tgcttctga  ggctcacag  540
cctcttcca  cctgtg  556



<210> 4604
<211> 354
<212> DNA
<213> Homo sapiens
<308> BF904759
<400> 4604

ccacacgaa  agcagagag  ggcagcagg  tgaatgtgg  cacagcgca  agcgaggtg  60
accccaaca  gcgggtgat  aacagccgt  gcatctggc  ctcctacgt  ctggccatc  120
gtctcctcc  catcgtgct  ctgagcatc  cgtttgtga  tgtccctgt  gtctggacc  180
tcaccacct  attcacaac  tggtgagag  ctgtctgct  cctgcccct  cccctgccc  240
tgccctgtg  gctgccctt  ggcagggct  agggatagg  gtagcctgt  gggcctggc  300
caggtgtca  ggtgatgta  tgacgacat  tgcctccag  gcccaggcc  agcc  354



<210> 4605
<211> 631
<212> DNA
<213> Rattus norvegicus
<308> AA800199
<400> 4605

gggagagta  cgtttattt  gtcctcaga  ccatctgag  caacatact  aactgagga  60
gaaattggg  tccaaaaga  ctcatcaag  aaagaaagg  actgcactt  ccagtggct  120
aacagttac  gtgatcagt  aggccggga  tacggttgc  accaaatcg  tctcgtgtg  180
cgccattac  aaagtacag  tttctcatc  caaattgtc  caaacccaa  ttacaaaag  240
aaaatcaca  ggtgcatat  ttaaaagac  gtgcccccc  cacctcata  gctacggta  300
tatcaagca  ggagaaggt  gcttttgct  cccctcggc  gtcatcttc  ccaacagcg  360
ggagaaggc  caggaagga  tggggcggg  cgctaattt  ccctcagta  aagatgaca  420
gtgaagctt  gtgggagac  ggagctggt  aggcttgag  ggaggaggc  ccaggccct  480
tgttcagtc  gagtcactg  tggaggagg  ggaggagga  gaggaggag  agtgcttcc  540
gtgcttatg  tgcttgtgt  atttcttgt  agctttctt  attttcttc  tagtcttct  600
gtctatcac  attcctggg  ctaccatgc  a  631



<210> 4606
<211> 562
<212> DNA
<213> Homo sapiens
<308> BE396293
<400> 4606

tattaatcc  ccctttccc  caggcccct  tcctcctcc  ccaggagct  cccatggca  60
tccagcttt  cccccaggt  ggccccctc  tcctgtgcc  cagccaggg  atccaggat  120
ccaaccgtt  ggtccctac  ctcctccat  cccaccgcc  gccctggaa  ccctcctgt  180
aatcccttg  ctcctggca  ggtggacca  cagtgatag  agacaagaa  atgcagaag  240
aaatgaaga  agctcataa  aagatgcac  agcaccaaa  gcaccacaa  taccacaag  300
atggcaagc  ttcctcctc  tcctcctcc  cttccagca  tgattctga  tgaatacag  360
ccctggacc  ttccctcaa  tctcaccag  tctgctctc  catcaagct  cagatgcca  420
gtcgtactg  gggaatgta  cccttgtgc  ccccacccc  aactccact  agctcacct  480
ctgttgacc  tgagtggta  gggaatggg  gaggatgca  ggctggcat  ttgagtgca  540
gtaaatcat  gtatgatag  gg  562



<210> 4607
<211> 727
<212> DNA
<213> Rattus norvegicus
<308> AA800212
<400> 4607

ccgccgcgg  ggaggagga  aaagaggag  ggacagctg  ccgcgcccg  gcgcccgcg  60
tggcacgag  ccgcggccc  agtgcgagg  ggaggcgag  aggccgcgg  gacgcgagg  120
gaggccggc  ggggccccc  cagccatgg  gaacgctca  acaaagacc  tggaggagg  180
gctgggcca  ttcggcgtc  acgagagca  ggggctgag  ctggagcag  tcaagaagc  240
caaggagag  tggggctcc  acgaattgc  ggctgaaga  ggaaagacc  tgctggaac  300
tgtgatcga  cagtttgaa  acttactag  tagaatttt  ttgctggca  catgtatat  360
tttcgtttt  gcttggttc  aagaaggtg  agaaacgat  acagccttt  tagaacctt  420
tgtaattct  cttatattg  tagccaatg  aattgtggg  gtatggcag  agagaaacg  480
tgaaaatgc  atagaagct  ttaaggagt  tgaacctga  atgggcaag  tgtatcgac  540
ggacagaaa  agtgtgcag  ggattaaag  gaaagatat  gttcctggg  atatagtgg  600
aattgctgt  ggtgacaaa  ttccggctg  cattagatt  acatccatc  agtctacaa  660
tctgagagt  gaccagtcg  ttcttacag  tgaatctgt  tcggtcatc  agcatactg  720
ccctgtc  727



<210> 4608
<211> 1043
<212> PRT
<213> Rattus norvegicus
<308> P11507
<400> 4608

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
  1               5                  10                  15
Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
             20                  25                  30
Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
         35                  40                  45
Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
     50                  55                  60
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
 65                  70                  75                  80
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                 85                  90                  95
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
             100                105                110
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
         115                120                125
Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
     130                135                140
Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
 145                150                155                160
Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                 165                170                175
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
             180                185                190
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
         195                200                205
Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
     210                215                220
Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
 225                230                235                240
Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                 245                250                255
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
             260                265                270
Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
         275                280                285
Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
     290                295                300
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
 305                310                315                320
Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                 325                330                335
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
             340                345                350
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
         355                360                365
Leu Asp Lys Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
     370                375                380
Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val Gln Lys Asp Asp Lys 
 385                390                395                400
Pro Val Lys Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                 405                410                415
Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
             420                425                430
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
         435                440                445
Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
     450                455                460
Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
 465                470                475                480
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                 485                490                495
Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
             500                505                510
Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
         515                520                525
Val Gly Ser Thr Lys Val Pro Met Thr Pro Gly Val Lys Gln Lys Ile 
     530                535                540
Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
 545                550                555                560
Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                 565                570                575
Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
             580                585                590
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
         595                600                605
Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
     610                615                620
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
 625                630                635                640
Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                 645                650                655
Phe Asp Glu Leu Ser Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
             660                665                670
Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
         675                680                685
Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
     690                695                700
Asn Asp Ala Pro Ala Leu Lys Lys Ser Glu Ile Gly Ile Ala Met Gly 
 705                710                715                720
Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                 725                730                735
Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
             740                745                750
Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
         755                760                765
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
     770                775                780
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
 785                790                795                800
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                 805                810                815
Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
             820                825                830
Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
         835                840                845
Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
     850                855                860
Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
 865                870                875                880
Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                 885                890                895
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
             900                905                910
Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
         915                920                925
Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
     930                935                940
Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
 945                950                955                960
Leu Asn Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                 965                970                975
Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
             980                985                990
Pro Gly Lys Glu Cys Ala Gln Pro Ala Thr Lys Pro Ser Cys Ser Leu 
         995                1000                1005
Ser Ala Cys Thr Asp Gly Ile Ser Trp Pro Phe Val Leu Leu Ile Met 
     1010                1015                1020
Pro Leu Val Val Trp Val Tyr Ser Thr Asp Thr Asn Phe Ser Asp Met 
 1025                1030                1035                1040
Phe Trp Ser 
                 1045



<210> 4609
<211> 4134
<212> DNA
<213> Homo sapiens
<308> M23114
<400> 4609

gggtgattc  gcgcccggc  aggcggaac  ggccgcaag  ggaggaggg  agagcccgt  60
cgcgcctgg  ctcccgggg  ggcacgagc  cgcggccgg  gtgcgaggc  gaggcgagg  120
ggccgcggg  acgggaggc  aggccggcc  ggcccccga  gccatggag  acgcgcaca  180
caagacggt  gaggaggtg  tgggccact  cggcgtcaa  gagagtacg  ggctgagcc  240
ggaacaggt  aagaagctt  aggagagat  gggctccaa  gagttaccg  ctgaagaag  300
aaaaacctt  ctggaactt  tgattgagc  gtttgaaga  ttgctagtt  ggattttat  360
actggcagc  tgtatatct  ttgttttgg  ttggtttga  gaaggtgaa  aaacaatta  420
agcctttgt  gaacctttt  taattttac  catattagt  gccaatgca  ttgtgggtg  480
atggcagga  agaaatgct  aaaatgcca  cgaagccct  aaggaatat  agcctgaaa  540
gggcaaagt  tatcgacag  acagaaaga  tgtgcagcg  attaaagct  aagacatag  600
tcctggtga  attgtagaa  ttgctgttg  tgacaaagt  cctgctgat  taaggttaa  660
ttccatcaa  tctaccaca  taagagttg  ccagtcaat  ctcacaggt  aatctgtct  720
tgtcatcaa  cacactgat  ccgtccctg  cccacgagc  gtcaaccaa  ataaaaaga  780
catgctgtt  tctggtaca  acattgctg  tgggaaagc  atgggagtg  tggtagcaa  840
tggagttaa  accgaaatt  gcaagatcc  ggatgaaat  gtggcaaca  aacaggaga  900
aacacccct  cagcaaaaa  tagatgaat  tggggaaca  ctttccaaa  tcatctccc  960
tatttgcat  gcagtctgg  tcataaata  tgggcactt  aatgacccg  ttcatggag  1020
gtcctggat  agaggtgct  tttactact  taaaattgc  gtggccctg  ctgtagcag  1080
cattcctga  ggtctgcct  cagtcatca  cacctgcct  gctcttgga  ctcgcagaa  1140
ggcaaagaa  aatgccatt  ttcgaagcc  cccgtctgt  gaaaccctt  gttgtactt  1200
tgttatctg  tcagacaag  ctggtacac  tacaacaaa  cagatgtca  tctgcagga  1260
gttcattct  gacagagtg  aaggtgata  ttgttccct  aatgagttt  ccataactg  1320
atcaactta  gcacctatt  gagaagtgc  taaagatga  aaaccagtg  attgtcacc  1380
gtatgatgg  ctggtagaa  tagcaacaa  ttgtgctct  tgtaatgac  ctgctttgg  1440
ttacaatga  gcaaagggt  tgtatgaaa  agttggaga  gctacagag  ctgctctca  1500
ttgcctagt  gagaagatg  atgtatttg  taccgaatt  aagggtctt  ctaaaatag  1560
acgtgcaaa  gcctgcaac  cagtcatta  acagctgat  aaaaaggaa  tcactctag  1620
gttttcacg  gacagaaag  caatgtcgg  ttactgtac  ccaaataaa  caagcagga  1680
atcaatgag  aagatgttt  tgaagggtg  tcctgaagg  gtcattgac  ggtgcaccc  1740
cattcgagt  ggaagtact  aggttccta  gacctctgg  gtcaaacag  agatcatgt  1800
tgtcattcg  gagtggggt  gtggcagcg  cacactgcg  tgcctggcc  tggccactc  1860
tgacaaccc  ctgagaaga  aagaaatgc  ccttgagga  tctgccaac  ttattaaat  1920
tgagaccaa  ctgaccttc  ttggctgcg  gggcatgct  gatcctccg  gaatcgagg  1980
ggcctcctc  gtgaagctg  gccggcaag  aggcatccg  gtcatcatg  tcactgggg  2040
caacaaggg  actgctgtg  ccatctgtc  ccgcatcgg  atcttcggg  aggatgagg  2100
cgtgacgtc  aaagctttc  caggccggg  gtttgatga  ctcaacccc  ccgcccagc  2160
agacgcctg  ctgaacgcc  gctgttttg  tcgagttga  ccctcccac  agtctaaaa  2220
cgtagaatt  cttcagtct  ttgatgaga  tacagctat  actggcgat  gcgtgaacg  2280
tgctcctgc  ctgaagaaa  ccgagattg  cattgctat  ggctctggc  ctgcggtgg  2340
taaaaccgc  tctgagatg  tcctggcgg  tgacaactt  tccaccatt  tggctgccg  2400
tgaggaggg  cgggcaatc  acaacaaca  gaaacagtt  atccgctac  tcatctcgt  2460
caacgtcgg  gaagttgtc  gtattttcc  gacagcagc  cttggattt  ccgaggctt  2520
gattcctgt  cagctgctc  gggtcaatc  ggtgacaga  ggcctgcct  ccactgcac  2580
ggggttcaa  cctcctgat  tggacatca  gaataaacc  ccccggaac  caaaggaac  2640
attgatcag  gggtggctc  ttttccgtt  cttggctat  ggctgttac  tcggcgctg  2700
taccgtggg  gctgctgca  ggtggttca  tgctgctga  ggtggtcca  gagtgtcct  2760
ctaccagct  agtcatttc  tacagtgta  agaggacaa  ccggacttt  aaggcgtgg  2820
ttgtgcaat  tttgaatcc  catacccga  gacaatggc  ctctctgtt  tagtaacta  2880
agaaatgtg  aacgccctc  acagcttgt  cgaaaacca  tccttgctg  ggatgcccc  2940
ctgggagaa  atctggctc  tgggctcca  ctgcctgtc  atgtcactc  acttcctga  3000
cctctatgt  gaacccttg  cactcatct  ccagatcac  ccgctgaac  tgacccagt  3060
gctgatggt  ctgaaaatc  ccttgcccg  gattctcat  gatgagacg  tcaagtttg  3120
ggcccgcaa  tacctggaa  ctggtaaag  gtgtgtgca  cctgccacc  aatcctgct  3180
gttctcggc  tgcaccgat  ggatttcct  gccgtttgt  ctgctcata  tgcccctgg  3240
gatctgggt  tatagcaca  acactaact  tagcgatat  ttctggtct  gactgacag  3300
tttccataa  gaagatgtt  aacttaatc  attaatttt  ttattgttt  aagcaactg  3360
ctatttctg  tgaattttc  catgaacat  ctggctggt  atggaggtt  catactcta  3420
attttgttt  gctttttct  actccagtg  ggcaagatt  tcctttttt  tacacataa  3480
taaagtgtc  attgacatg  acagagaac  aacactatt  tatgcaaat  tttttttgt  3540
gatgaaaaa  catgtacag  gttctgttt  atactcatc  ttgtataaa  aaaatagtt  3600
agccagcag  cattgtcag  aaattaatt  gcagcagat  ttaggaaat  aatgtgtgt  3660
gtttttttt  taaaactaa  tagcatgta  tgtgtcttt  gcatgatga  ccggattta  3720
tttgatatc  cagtctaat  tttattcat  agccaattt  tctgcactg  gcagagtct  3780
gctacctca  tcagtattg  tttggtttg  tacttccct  acccacttt  gcctccgtt  3840
accccaccc  accccacct  tccccacct  acccccgcc  cgcttggct  cttctttag  3900
attgtgatg  ttcgttctg  ttacatcag  tttaacgag  ggtatgcct  tactcgctt  3960
tgcagaaaa  attgttcca  attcaatcg  ctgggttta  gtcccttca  atagttttt  4020
aggttattt  tttaaatgt  taatgtatt  tattgtaac  gacattgtt  tgccaacat  4080
gcctatttc  gtggcacgt  atctagttt  aaaaaaata  aacatttta  aaag  4134



<210> 4610
<211> 1042
<212> PRT
<213> Homo sapiens
<308> P16615
<400> 4610

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
  1               5                  10                  15
Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
             20                  25                  30
Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
         35                  40                  45
Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
     50                  55                  60
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
 65                  70                  75                  80
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                 85                  90                  95
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
             100                105                110
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
         115                120                125
Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
     130                135                140
Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
 145                150                155                160
Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                 165                170                175
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
             180                185                190
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
         195                200                205
Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
     210                215                220
Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
 225                230                235                240
Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                 245                250                255
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
             260                265                270
Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
         275                280                285
Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
     290                295                300
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
 305                310                315                320
Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                 325                330                335
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
             340                345                350
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
         355                360                365
Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
     370                375                380
Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
 385                390                395                400
Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                 405                410                415
Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
             420                425                430
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
         435                440                445
Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
     450                455                460
Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
 465                470                475                480
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                 485                490                495
Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
             500                505                510
Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
         515                520                525
Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
     530                535                540
Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
 545                550                555                560
Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                 565                570                575
Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
             580                585                590
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
         595                600                605
Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
     610                615                620
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
 625                630                635                640
Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                 645                650                655
Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
             660                665                670
Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
         675                680                685
Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
     690                695                700
Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
 705                710                715                720
Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                 725                730                735
Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
             740                745                750
Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
         755                760                765
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
     770                775                780
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
 785                790                795                800
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                 805                810                815
Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
             820                825                830
Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
         835                840                845
Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
     850                855                860
Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
 865                870                875                880
Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                 885                890                895
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
             900                905                910
Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
         915                920                925
Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
     930                935                940
Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
 945                950                955                960
Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                 965                970                975
Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
             980                985                990
Pro Gly Lys Glu Cys Val Gln Pro Ala Thr Lys Ser Cys Ser Phe Ser 
         995                1000                1005
Ala Cys Thr Asp Gly Ile Ser Trp Pro Phe Val Leu Leu Ile Met Pro 
     1010                1015                1020
Leu Val Ile Trp Val Tyr Ser Thr Asp Thr Asn Phe Ser Asp Met Phe 
 1025                1030                1035                1040
Trp Ser 
                 1045



<210> 4611
<211> 711
<212> DNA
<213> Rattus norvegicus
<308> AA800220
<400> 4611

gcaatttag  agagtttat  taggcaagt  ccaggccag  aggggtatg  agtaagatc  60
tatcttaaa  aaaaaaaaa  aaagaaaag  aatagtact  tataaaaca  ttgataaag  120
caaaattaa  ttttatttc  cattgatag  aactgtgaa  aacatgaca  tttcccaca  180
tacagcaca  aaattcaac  gaatatttc  taccccaaa  aaattttta  agatacaat  240
actgaagta  atgtatgct  ttcaaagta  agcaaaata  taaatgatt  tttgaaatt  300
ttttaaatc  agacataaa  aatcggctt  attgttaac  ctctatctc  gacacacca  360
atgacccca  atcagttag  tcctgctta  aaagatgct  ccttcttct  ggtcggttg  420
aaaacagca  gaaaagaaa  cgttcagaa  taaccataa  ttttgtaac  tactcaact  480
tgtggaaac  gttataaat  tgggtttat  tatgtgggt  ctaaccagt  cttattatc  540
ataaattaa  taattttca  cagtatttt  aacatgttg  tgatttaaa  tcaaatgat  600
gttatttta  tatttgcac  ggagactga  tatcaaaag  tcctttact  aagatgaaa  660
tttcaaatt  gcatgttac  cagatgaaa  taanacaag  ttgactgct  a  711



<210> 4612
<211> 230
<212> PRT
<213> Rattus norvegicus
<308> NP_037138
<400> 4612

Met Cys Gly Asn Asn Met Ser Ala Pro Met Pro Ala Val Val Pro Ala 
  1               5                  10                  15
Ala Arg Lys Ala Thr Ala Ala Val Ile Phe Leu His Gly Leu Gly Asp 
             20                  25                  30
Thr Gly His Gly Trp Ala Glu Ala Phe Ala Gly Ile Lys Ser Ser His 
         35                  40                  45
Ile Lys Tyr Ile Cys Pro His Ala Pro Val Met Pro Val Thr Leu Asn 
     50                  55                  60
Met Ser Met Met Met Pro Ser Trp Phe Asp Ile Ile Gly Leu Ser Pro 
 65                  70                  75                  80
Asp Ser Gln Glu Asp Glu Ser Gly Ile Lys Gln Ala Ala Glu Thr Val 
                 85                  90                  95
Lys Ala Leu Ile Asp Gln Glu Val Lys Asn Gly Ile Pro Ser Asn Arg 
             100                105                110
Ile Ile Leu Gly Gly Phe Ser Gln Gly Gly Ala Leu Ser Leu Tyr Thr 
         115                120                125
Ala Leu Thr Thr Gln Gln Lys Leu Ala Gly Val Thr Ala Leu Ser Cys 
     130                135                140
Trp Leu Pro Leu Arg Ala Ser Phe Ser Gln Gly Pro Ile Asn Ser Ala 
 145                150                155                160
Asn Arg Asp Ile Ser Val Leu Gln Cys His Gly Asp Cys Asp Pro Leu 
                 165                170                175
Val Pro Leu Met Phe Gly Ser Leu Thr Val Glu Arg Leu Lys Gly Leu 
             180                185                190
Val Asn Pro Ala Asn Val Thr Phe Lys Val Tyr Glu Gly Met Met His 
         195                200                205
Ser Ser Cys Gln Gln Glu Met Met Asp Val Lys Tyr Phe Ile Asp Lys 
     210                215                220
Leu Leu Pro Pro Ile Asp 
 225                230



<210> 4613
<211> 442
<212> DNA
<213> Homo sapiens
<308> BE018412
<400> 4613

ggatgaatc  gggattaaa  aggcagcag  aaatataaa  gctttgatt  atcaagaag  60
gaagaatgg  attccttct  acagaatta  tttgggagg  ttttctcag  gaggagctt  120
atctttata  actgccctt  ccacacagc  gaaactggc  ggtgtcact  cactcagtt  180
ctggcttcc  cttcgggct  cctttccac  gtgccacgg  gattgtgac  ctttggttc  240
cctgatgtt  ggttctctt  cggtggaaa  actaaaaac  ttggtgaat  cagccaatg  300
gacctttaa  acctatgaa  gtatgatgc  cagttcgtg  caacaggaa  tgatggatg  360
caagcaatt  attgataaa  tcctacctc  aattgattg  cgtcactaa  aggccttgt  420
tagaagtac  ccagcatta  tg  442



<210> 4614
<211> 230
<212> PRT
<213> Homo sapiens
<308> NP_006321
<400> 4614

Met Cys Gly Asn Asn Met Ser Thr Pro Leu Pro Ala Ile Val Pro Ala 
  1               5                  10                  15
Ala Arg Lys Ala Thr Ala Ala Val Ile Phe Leu His Gly Leu Gly Asp 
             20                  25                  30
Thr Gly His Gly Trp Ala Glu Ala Phe Ala Gly Ile Arg Ser Ser His 
         35                  40                  45
Ile Lys Tyr Ile Cys Pro His Ala Pro Val Arg Pro Val Thr Leu Asn 
     50                  55                  60
Met Asn Val Ala Met Pro Ser Trp Phe Asp Ile Ile Gly Leu Ser Pro 
 65                  70                  75                  80
Asp Ser Gln Glu Asp Glu Ser Gly Ile Lys Gln Ala Ala Glu Asn Ile 
                 85                  90                  95
Lys Ala Leu Ile Asp Gln Glu Val Lys Asn Gly Ile Pro Ser Asn Arg 
             100                105                110
Ile Ile Leu Gly Gly Phe Ser Gln Gly Gly Ala Leu Ser Leu Tyr Thr 
         115                120                125
Ala Leu Thr Thr Gln Gln Lys Leu Ala Gly Val Thr Ala Leu Ser Cys 
     130                135                140
Trp Leu Pro Leu Arg Ala Ser Phe Pro Gln Gly Pro Ile Gly Gly Ala 
 145                150                155                160
Asn Arg Asp Ile Ser Ile Leu Gln Cys His Gly Asp Cys Asp Pro Leu 
                 165                170                175
Val Pro Leu Met Phe Gly Ser Leu Thr Val Glu Lys Leu Lys Thr Leu 
             180                185                190
Val Asn Pro Ala Asn Val Thr Phe Lys Thr Tyr Glu Gly Met Met His 
         195                200                205
Ser Ser Cys Gln Gln Glu Met Met Asp Val Lys Gln Phe Ile Asp Lys 
     210                215                220
Leu Leu Pro Pro Ile Asp 
 225                230



<210> 4615
<211> 459
<212> DNA
<213> Rattus norvegicus
<308> AA800221
<400> 4615

ccaattgag  aagcacgtc  agccttctg  cccctttga  ctactgttc  cctttgggg  60
cgtatttta  ttcactttt  acgttttgg  tctcagaca  gttgacgac  ggtcctggg  120
atttcttca  tccaggaac  ggcttcttt  cctcgggag  agcaggtgc  ccctccgca  180
ttccagggg  actctcttt  cttctggga  gctgcccag  tcccggacg  aaggctccc  240
ttggaatat  aatattggc  tgaatggat  tgacgttgg  aattggctg  ttcgacatg  300
tcaagaggt  ttatacctg  tctctggat  tgtttactg  ctgaggaca  tcctaggca  360
ccaggtgca  aaacagaaa  cgctttaca  ggtagaagg  actcccggt  tcctctgag  420
tgagatctc  attccagtg  ttttcatgt  cctcgtgcc  459



<210> 4616
<211> 85
<212> PRT
<213> Rattus norvegicus
<308> AAK50399
<400> 4616

Met Ser Lys Gln Pro Ile Ser Asn Val Arg Ser Ile Gln Ala Asn Ile 
  1               5                  10                  15
Asn Ile Pro Met Gly Ala Phe Arg Pro Gly Ala Gly Gln Pro Pro Arg 
             20                  25                  30
Arg Lys Glu Ser Thr Pro Gly Thr Ala Glu Gly Ala Pro Ala Thr Pro 
         35                  40                  45
Glu Glu Lys Lys Pro Val Pro Gly Met Lys Lys Phe Pro Gly Pro Val 
     50                  55                  60
Val Asn Leu Ser Glu Ile Gln Asn Val Lys Ser Glu Leu Lys Tyr Val 
 65                  70                  75                  80
Pro Lys Gly Glu Gln 
                 85



<210> 4617
<211> 886
<212> DNA
<213> Homo sapiens
<308> AF129505
<400> 4617

gttctcaat  ccgggagag  cacagagct  tttcagcca  atgaaaagc  tcggaattg  60
gatcgcagc  cagaggaca  cgggcgccc  ttccacctt  caaggagct  tgtattctt  120
catctggct  cctgggact  cccttaggc  gtaaacaaa  acataaagc  gggataaga  180
tgcatgaat  tgtcgaaac  gccagtttc  aatgttaga  ccatccagg  aaatatcaa  240
attccaatg  gagcctttc  gccaggagc  ggtcaaccc  ccagaagaa  agaatgtac  300
cctgaagtg  aggagggtg  tcctcccac  tcggatgag  agaagaagc  aattccagg  360
gcgaagaaa  ttccaggac  tgcagtcaa  ctatcggaa  tccagaata  taaaagtga  420
ctaaaatat  tccccaaag  tgaacagta  taggaagaa  aaaggattg  tgtgaagaa  480
taaagaggc  gaagatgga  tcaatagct  actaaaatt  tatatattt  tatgatgat  540
gtgaacctc  tgaatgcct  agactctag  agaaatggc  tgtttgtac  tttatatct  600
ttccttcta  ttggctgta  ttcttactt  atcttcatt  ttggcacct  acagaacaa  660
ttagcccat  aattcaaca  ctggagggt  tggttttga  gagggatat  attttatgg  720
gaatgatat  gcaatgtgc  taacgattt  gatgaaaag  ttcccaagc  acttcctac  780
gtattttgg  caatatttg  aatgcgttt  agttcttca  cttttaaat  atgtcacta  840
actttgtat  agttcaaat  aatatttga  taaatgtaa  atgtga  886



<210> 4618
<211> 88
<212> PRT
<213> Homo sapiens
<308> Q9UHP9
<400> 4618

Met Asn Met Ser Lys Gln Pro Val Ser Asn Val Arg Ala Ile Gln Ala 
  1               5                  10                  15
Asn Ile Asn Ile Pro Met Gly Ala Phe Arg Pro Gly Ala Gly Gln Pro 
             20                  25                  30
Pro Arg Arg Lys Glu Cys Thr Pro Glu Val Glu Glu Gly Val Pro Pro 
         35                  40                  45
Thr Ser Asp Glu Glu Lys Lys Pro Ile Pro Gly Ala Lys Lys Leu Pro 
     50                  55                  60
Gly Pro Ala Val Asn Leu Ser Glu Ile Gln Asn Ile Lys Ser Glu Leu 
 65                  70                  75                  80
Lys Tyr Val Pro Lys Ala Glu Gln 
                 85



<210> 4619
<211> 583
<212> DNA
<213> Rattus norvegicus
<308> AA800224
<400> 4619

accaaaaaa  attccaggt  cctcttcag  tagatcact  tcaaaatat  tttatagac  60
ctttgccag  gctgtcatc  caaaagctg  cagaactct  gaagtcccg  ggtccagcc  120
tcagcccag  aatataggt  gagtctcca  gatgggtgg  aagagagca  tacctgggc  180
gtgctggct  cttctttcc  cataggtaa  gtatgacat  aaaggacaa  aaatacgtg  240
tgaatatta  caaaaaaag  ttacaagtc  tatgctttg  tgccgtggc  ctttgaagt  300
catctacct  actggcagc  ggaagacag  tctgctgct  cgttctcag  tcttggcct  360
ctgggctgt  tccacacta  accctatgg  tatactgtc  tgatttttc  agaattcac  420
taagaggaa  aaagcagaa  ccttagctg  aagtacatt  cccaattta  attgtggta  480
attagtgat  acatgaaaa  ctgagggat  atggtggta  agtcacatc  ccaggggcc  540
agacatctt  cttgtgaac  cagtgagtc  caggaggaa  agc  583



<210> 4620
<211> 2251
<212> DNA
<213> Homo sapiens
<308> AK001441
<400> 4620

gacgtcacg  tcactgaca  cgtgagccc  cggcggctg  tgccatggt  gctggcggc  60
gggtaaggg  ctgagtgga  ctcctgcca  gccagagcg  cttcggggg  cgcggcgga  120
ggccaggag  ttgcagcca  ggcgccggg  ttgtggtct  cagtgtcgt  aggctgagg  180
gcagcatgt  tagactggg  gccctgggt  gtgcccgtg  cgggctggg  ctgttgctg  240
gtaccgccg  cggccttgg  ttcctgtgc  tcctttaca  ccagcgatg  aaacggacc  300
agcgtcatg  ccgcagcca  agcctgccc  actccctgg  ctatacgca  acttcagat  360
ccggacgcc  cgtgatgct  ctgcgggct  tcccaggtg  ggctggaga  gcctcagtg  420
tgcccagcc  tccacggga  ggacaggag  aggtgctgg  ccgcctgga  tttgtgctg  480
ccagccttg  ggcgctgcg  cgggaggtg  aggagctga  aagcagcct  cgagggctt  540
cgggggaga  tgttgggga  gtccgatgc  acatggaag  gaaccagag  gtggctcgg  600
ggcgaaggt  tccgtttgt  cgggagagg  gtgactcca  tggctccag  tctgtctac  660
tcacggcct  ctcgggagc  acgttcaca  atgctgaga  tgaaggggg  tacacaaca  720
ccaatgcgg  gtctgacaa  gagcgggac  ctgacaaag  aagtgagga  ggggaagat  780
aagtgagct  tgagactgt  aagatgggg  gaaaggatt  tcttgactt  gaggaagag  840
cagcttcag  tgcctccag  gccctggag  ctggaggtt  ctcaggctt  gaggatgtg  900
tgcccctcc  gcagcaggc  gacgagctg  acaggggtg  tgagcaagg  aagcgggag  960
gcttccagc  gctgctcaa  aacaagctg  tgtatggaa  ccggcagga  tttctctgg  1020
gcctggccc  agcctacag  gacatgtgt  agctcactg  ggaggtgag  gagaagaag  1080
catatgccc  agatggaaa  gaagaagca  aggctgctc  ggagaaggg  gatgagagt  1140
ctgactgtc  cctgtggta  gcggtgctt  gtggtcagc  ggctgagca  gagagcatc  1200
agaggcgca  ccagagtgg  tttagcttc  aggagcatg  ggacaaagc  attgctctc  1260
agccagaaa  ccccatggc  cactttctt  ttggcaggt  gtgctatca  gtctctcac  1320
tgagctggc  agaaaaaaa  actgctaca  ccttgcttg  aagccctct  agtgccact  1380
tggaagatg  cctccagag  ttcctaaag  ctgaagaac  acagccagg  ttttccaaa  1440
caggaaggg  atatatttc  aagtgctac  gagaactag  gaaaaactc  gaagctaga  1500
ggtggatga  gttggccct  gagctgcca  atgtcacga  ggaggattt  gctatccag  1560
aggacctgg  agaactgga  gtcatttta  gagactaac  acgtttcac  ggccttcat  1620
acttgatgc  actatttaa  gtggggggg  ggggaggct  ttttcctta  accttgctg  1680
gatcaggaa  ccacacaaa  ctgtctcct  ggtctgact  ctacccact  ccactcccc  1740
ttagttaat  tattctaac  tctaaccta  tctagaatt  gggcagtac  catggcttc  1800
gtttctgtt  ttctctccc  tgagtaatc  cttaaaaaa  tcaagattc  cacctgccc  1860
aggattaca  atgggtaga  cctgcaaga  ctgagacct  ccaattgct  gtgaggtgg  1920
tgaacttca  agctatagg  acaaagcac  taacttgtc  ctttaatct  tttcactga  1980
taataggac  cagtacata  agtcttaag  tcatacctt  cctaccaag  taaaaagag  2040
gatcagagt  gcccacaga  attgctttc  tatcaccta  catgtgaat  ctacctgta  2100
tccagggct  gaccacttg  taacttcca  tgtcctggc  gcttttgga  tgacagcag  2160
ggtatgggg  ttatgatgc  ataaaacaa  gtctgaaaa  ttgcctaga  tatattttg  2220
tacaaactt  aaataaacc  aatttgatg  t  2251



<210> 4621
<211> 471
<212> PRT
<213> Homo sapiens
<308> AK001441
<400> 4621

Met Ser Arg Leu Gly Ala Leu Gly Gly Ala Arg Ala Gly Leu Gly Leu 
  1               5                  10                  15
Leu Leu Gly Thr Ala Ala Gly Leu Gly Phe Leu Cys Leu Leu Tyr Ser 
             20                  25                  30
Gln Arg Trp Lys Arg Thr Gln Arg His Gly Arg Ser Gln Ser Leu Pro 
         35                  40                  45
Asn Ser Leu Asp Tyr Thr Gln Thr Ser Asp Pro Gly Arg His Val Met 
     50                  55                  60
Leu Leu Arg Ala Val Pro Gly Gly Ala Gly Asp Ala Ser Val Leu Pro 
 65                  70                  75                  80
Ser Leu Pro Arg Glu Gly Gln Glu Lys Val Leu Asp Arg Leu Asp Phe 
                 85                  90                  95
Val Leu Thr Ser Leu Val Ala Leu Arg Arg Glu Val Glu Glu Leu Arg 
             100                105                110
Ser Ser Leu Arg Gly Leu Ala Gly Glu Ile Val Gly Glu Val Arg Cys 
         115                120                125
His Met Glu Glu Asn Gln Arg Val Ala Arg Arg Arg Arg Phe Pro Phe 
     130                135                140
Val Arg Glu Arg Ser Asp Ser Thr Gly Ser Ser Ser Val Tyr Phe Thr 
 145                150                155                160
Ala Ser Ser Gly Ala Thr Phe Thr Asp Ala Glu Ser Glu Gly Gly Tyr 
                 165                170                175
Thr Thr Ala Asn Ala Glu Ser Asp Asn Glu Arg Asp Ser Asp Lys Glu 
             180                185                190
Ser Glu Asp Gly Glu Asp Glu Val Ser Cys Glu Thr Val Lys Met Gly 
         195                200                205
Arg Lys Asp Ser Leu Asp Leu Glu Glu Glu Ala Ala Ser Gly Ala Ser 
     210                215                220
Ser Ala Leu Glu Ala Gly Gly Ser Ser Gly Leu Glu Asp Val Leu Pro 
 225                230                235                240
Leu Leu Gln Gln Ala Asp Glu Leu His Arg Gly Asp Glu Gln Gly Lys 
                 245                250                255
Arg Glu Gly Phe Gln Leu Leu Leu Asn Asn Lys Leu Val Tyr Gly Ser 
             260                265                270
Arg Gln Asp Phe Leu Trp Arg Leu Ala Arg Ala Tyr Ser Asp Met Cys 
         275                280                285
Glu Leu Thr Glu Glu Val Ser Glu Lys Lys Ser Tyr Ala Leu Asp Gly 
     290                295                300
Lys Glu Glu Ala Glu Ala Ala Leu Glu Lys Gly Asp Glu Ser Ala Asp 
 305                310                315                320
Cys His Leu Trp Tyr Ala Val Leu Cys Gly Gln Leu Ala Glu His Glu 
                 325                330                335
Ser Ile Gln Arg Arg Ile Gln Ser Gly Phe Ser Phe Lys Glu His Val 
             340                345                350
Asp Lys Ala Ile Ala Leu Gln Pro Glu Asn Pro Met Ala His Phe Leu 
         355                360                365
Leu Gly Arg Trp Cys Tyr Gln Val Ser His Leu Ser Trp Leu Glu Lys 
     370                375                380
Lys Thr Ala Thr Ala Leu Leu Glu Ser Pro Leu Ser Ala Thr Val Glu 
 385                390                395                400
Asp Ala Leu Gln Ser Phe Leu Lys Ala Glu Glu Leu Gln Pro Gly Phe 
                 405                410                415
Ser Lys Ala Gly Arg Val Tyr Ile Ser Lys Cys Tyr Arg Glu Leu Gly 
             420                425                430
Lys Asn Ser Glu Ala Arg Trp Trp Met Lys Leu Ala Leu Glu Leu Pro 
         435                440                445
Asp Val Thr Lys Glu Asp Leu Ala Ile Gln Lys Asp Leu Glu Glu Leu 
     450                455                460
Glu Val Ile Leu Arg Asp Ter 
 465                470



<210> 4622
<211> 669
<212> DNA
<213> Rattus norvegicus
<308> AA800228
<400> 4622

caggggcag  gtgggtcac  gttgagttt  ttgccagtg  taggagggt  ggggaatcc  60
tggctgggg  ctgagtgga  aagtttctg  ctgggcact  cagggccca  gagtaggga  120
gaggcctgt  gtccccacc  ctaaggcag  ctcagggtg  tggctgcaa  ggacctact  180
acaacaggg  ggcctgggt  gccttgggg  tcacctgaa  caataagtt  ttgtcaaag  240
cctatgtct  atcacccaa  actgggtta  aggcatgct  gagatttga  ctcaggtcc  300
caagcttgc  gaggaccgt  ctccaggga  aggccttgc  ggagaatcc  cgttcacag  360
ggggtgtca  acaggtcct  cctagggtg  aggactggc  agcacttgt  agcagctct  420
agttgctgg  ctctgtgca  agggtgcta  gccaagttg  ggtgcaaat  ccccaaatg  480
ttaccctgt  gtcccggaa  acctacaag  ccacctaga  aaccactga  cccttcatc  540
cggccatct  tgctcacat  ttacttcca  actgggtct  ataaaggtc  ttattgtgt  600
aggccctta  cctctcatt  agtaatggg  tctctanag  ggacacatc  taactccaa  660
gggactcca  669



<210> 4623
<211> 227
<212> PRT
<213> Rattus norvegicus
<308> CAA62001
<400> 4623

Ser Arg Arg Asp Pro Cys Gln Pro Ala Pro Arg Ser Arg Glu Ile Gly 
  1               5                  10                  15
Cys Cys Pro Leu Gln Glu Thr Val Pro Gly Pro Ser Cys Gln Gly Glu 
             20                  25                  30
Thr Glu Ser Ile Ala Gly Glu Ala Ser Glu Gln Gly Glu Ala Arg Pro 
         35                  40                  45
Cys Pro Glu Gly His Gln Ser Pro Ser Pro Ala Pro Val Leu Gln Ser 
     50                  55                  60
Pro Pro Gly Ser Pro Ala Gly Pro Ala Met Thr Ser Glu Ser Thr Ser 
 65                  70                  75                  80
Pro Pro Val Val Pro Pro Leu His Ser Pro Lys Ser Pro Val Trp Pro 
                 85                  90                  95
Thr Phe Pro Phe His Arg Glu Ser Ser Arg Ile Trp Glu Arg Gly Gly 
             100                105                110
Gly Val Ser Pro Arg Asp Leu Pro Ser Pro Leu Pro Thr Lys Arg Thr 
         115                120                125
Arg Thr Tyr Ser Ala Thr Ala Arg Ala Ser Ala Gly Pro Val Phe Lys 
     130                135                140
Gly Val Cys Lys Gln Phe Ser Arg Ser Gln Gly His Gly Phe Ile Thr 
 145                150                155                160
Pro Glu Asn Gly Ser Glu Asp Ile Phe Val His Val Ser Asp Ile Glu 
                 165                170                175
Gly Glu Tyr Val Pro Val Glu Gly Asp Glu Val Thr Tyr Lys Met Cys 
             180                185                190
Pro Ile Pro Pro Lys Asn Gln Lys Phe Gln Ala Val Glu Val Val Leu 
         195                200                205
Thr Gln Leu Ala Pro His Thr Pro His Glu Thr Trp Ser Gly Gln Val 
     210                215                220
Val Gly Ser 
 225



<210> 4624
<211> 1157
<212> DNA
<213> Homo sapiens
<308> AB027011
<400> 4624

gctctcctg  tggccccac  atgacttca  agtcgacgt  acccccagt  gtgcccccg  60
tccactccc  caagtcccc  gtctggccc  ccttcccct  ccacaggga  ggcagcagg  120
tctgggagc  gggtggtgt  ccacctcgg  acctaccca  ccctctgcc  accaagcgg  180
ccaggacct  ttcagcgac  gcccgggcc  cagctggcc  cgtgttcaa  ggcgtctgt  240
agcagttct  acgctcaca  ggccatggc  tcatcaccc  cgagaacgg  tccgaggac  300
tcttcgtac  tgtgtctga  atcgagggg  agtacgtgc  agtggaggg  gacgaggtg  360
cctacaaga  gtgccctat  cctcccaag  accagaagt  ccaggccgt  gaggtggtg  420
tcactcagc  ggcccccca  actccccac  agacgtggt  tggccaggt  gtgggctcc  480
aggctgagt  gttcacagg  cagctggcc  ggggttggg  agccacaca  ggtgaacgg  540
cagcagccg  ctccatgcc  cactgccct  gctgatgag  ccttcggtg  cctcagtgt  600
cacgtctgt  tgtccgtct  tgcttgtgg  tatgagcgt  tgcctccac  caccccacg  660
cccgtgact  ctgtgcagc  ggccaggag  taggtggag  gcaaggcca  cagacctgg  720
ttcgcgctg  ccactgcct  tctcctccc  tccctgccg  agacacgca  gacccgctc  780
ccctcctgc  tacccgtcc  cacggtgac  gagctgcga  agcctgcgc  gggctcact  840
cctggcctc  gcccctgag  tgtcccgtg  cagtccctg  cccggagcc  ggctctctg  900
gctacttac  tctccctcc  ttggctgag  tcccccgcc  cagcctgga  ccttccctc  960
gaagcctgg  cgatgggtg  ttttgggga  cctctcagc  tctggcagg  gaggaggac  1020
gacacggag  cacacaggc  tctcactgc  gaggccagc  ttccttcct  ctctgctct  1080
tcagtgcca  ggagaggca  gaagagggg  ctgagggcg  aaggggttt  gggctccca  1140
ttcgccggc  agtccct  1157



<210> 4625
<211> 153
<212> PRT
<213> Homo sapiens
<308> CAB46024
<400> 4625

Met Thr Ser Glu Ser Thr Ser Pro Pro Val Val Pro Pro Leu His Ser 
  1               5                  10                  15
Pro Lys Ser Pro Val Trp Pro Thr Phe Pro Phe His Arg Glu Gly Ser 
             20                  25                  30
Arg Val Trp Glu Arg Gly Gly Val Pro Pro Arg Asp Leu Pro Ser Pro 
         35                  40                  45
Leu Pro Thr Lys Arg Thr Arg Thr Tyr Ser Ala Thr Ala Arg Ala Ser 
     50                  55                  60
Ala Gly Pro Val Phe Lys Gly Val Cys Lys Gln Phe Ser Arg Ser Gln 
 65                  70                  75                  80
Gly His Gly Phe Ile Thr Pro Glu Asn Gly Ser Glu Asp Ile Phe Val 
                 85                  90                  95
His Val Ser Asp Ile Glu Gly Glu Tyr Val Pro Val Glu Gly Asp Glu 
             100                105                110
Val Thr Tyr Lys Met Cys Pro Ile Pro Pro Lys Asn Gln Lys Phe Gln 
         115                120                125
Ala Val Glu Val Val Leu Thr Gln Leu Ala Pro His Thr Pro His Glu 
     130                135                140
Thr Trp Ser Gly Gln Val Val Gly Ser 
 145                150



<210> 4626
<211> 613
<212> DNA
<213> Rattus norvegicus
<308> AA800243
<400> 4626

acaatatgc  agagactga  tcgtatgtt  ccagacact  tgctgttag  cgcttccta  60
agctcttga  aggcccatc  gcctccttt  tcttgcggg  atcctgctg  tcggtcctg  120
cctgggtac  accaccaaa  cccgttcct  cctctgaca  cccacagcc  gtaacagat  180
gtagagaat  tgcgtgaaa  ctgggtccc  ggacctctg  atctgtgat  tgattacat  240
aaccagcct  tggcgctag  cttggggga  ggctgctct  ctgtgtcac  cagtgctcg  300
agcacataa  cgcccgcat  aaccaggaa  tgtccggtc  cctgggcag  ataggatgc  360
aaccgcagc  gactcctta  caaggcctt  aagcttgtg  agcggatat  atacgacac  420
gagtacatc  catacatgg  ggctttgac  ttgagacag  cgaggaagt  cttgggatt  480
agcctgtat  ggtcgaagg  gactctggc  attcctgac  tctttgttt  tgtgcagac  540
tacttattg  ccggtgtcc  tttctgtcc  ttttccaag  tcatgaagt  tgtgttgtc  600
cttagggtc  gaa  613



<210> 4627
<211> 217
<212> PRT
<213> Rattus norvegicus
<308> NP_031728
<400> 4627

Met Glu Thr Ala Arg Asp Tyr Ala Gly Ala Leu Ile Arg Pro Leu Thr 
  1               5                  10                  15
Phe Met Gly Leu Gln Thr Lys Lys Val Leu Leu Thr Pro Leu Ile His 
             20                  25                  30
Pro Ala Arg Pro Phe Arg Val Ser Asn His Asp Arg Ser Ser Arg Arg 
         35                  40                  45
Gly Val Met Ala Ser Ser Leu Gln Glu Leu Ile Ser Lys Thr Leu Asp 
     50                  55                  60
Val Leu Val Ile Thr Thr Gly Leu Val Thr Leu Val Leu Glu Glu Asp 
 65                  70                  75                  80
Gly Thr Val Val Asp Thr Glu Glu Phe Phe Gln Thr Leu Arg Asp Asn 
                 85                  90                  95
Thr His Phe Met Ile Leu Glu Lys Gly Gln Lys Trp Thr Pro Gly Ser 
             100                105                110
Lys Tyr Val Pro Val Cys Lys Gln Pro Lys Lys Ser Gly Ile Ala Arg 
         115                120                125
Val Thr Phe Asp Leu Tyr Arg Leu Asn Pro Lys Asp Phe Leu Gly Cys 
     130                135                140
Leu Asn Val Lys Ala Thr Met Tyr Glu Met Tyr Ser Val Ser Tyr Asp 
 145                150                155                160
Ile Arg Cys Thr Arg Phe Lys Ala Val Leu Arg Asn Leu Leu Arg Phe 
                 165                170                175
Met Ser Tyr Ala Ala Gln Met Thr Gly Gln Phe Leu Val Tyr Ala Gly 
             180                185                190
Thr Tyr Met Leu Arg Val Leu Gly Asp Thr Glu Glu Gln Pro Ser Pro 
         195                200                205
Lys Pro Ser Thr Lys Gly Trp Phe Met 
     210                215



<210> 4629
<211> 219
<212> PRT
<213> Homo sapiens
<308> O60543
<400> 4629

Met Glu Ala Ala Arg Asp Tyr Ala Gly Ala Leu Ile Arg Pro Leu Thr 
  1               5                  10                  15
Phe Met Gly Ser Gln Thr Lys Arg Val Leu Phe Thr Pro Leu Met His 
             20                  25                  30
Pro Ala Arg Pro Phe Arg Val Ser Asn His Asp Arg Ser Ser Arg Arg 
         35                  40                  45
Gly Val Met Ala Ser Ser Leu Gln Glu Leu Ile Ser Lys Thr Leu Asp 
     50                  55                  60
Ala Leu Val Ile Ala Thr Gly Leu Val Thr Leu Val Leu Glu Glu Asp 
 65                  70                  75                  80
Gly Thr Val Val Asp Thr Glu Glu Phe Phe Gln Thr Leu Gly Asp Asn 
                 85                  90                  95
Thr His Phe Met Ile Leu Glu Lys Gly Gln Lys Trp Met Pro Gly Ser 
             100                105                110
Gln His Val Pro Thr Cys Ser Pro Pro Lys Arg Ser Gly Ile Ala Arg 
         115                120                125
Val Thr Phe Asp Leu Tyr Arg Leu Asn Pro Lys Asp Phe Ile Gly Cys 
     130                135                140
Leu Asn Val Lys Ala Thr Met Tyr Glu Met Tyr Ser Val Ser Tyr Asp 
 145                150                155                160
Ile Arg Cys Thr Gly Leu Lys Gly Leu Leu Arg Ser Leu Leu Arg Phe 
                 165                170                175
Leu Ser Tyr Ser Ala Gln Val Thr Gly Gln Phe Leu Ile Tyr Leu Gly 
             180                185                190
Thr Tyr Met Leu Arg Val Leu Asp Asp Lys Glu Glu Arg Pro Ser Leu 
         195                200                205
Arg Ser Gln Ala Lys Gly Arg Phe Thr Cys Gly 
     210                215



<210> 4630
<211> 623
<212> DNA
<213> Rattus norvegicus
<308> AA800260
<400> 4630

agcaaggat  gtgtgccga  ctctgcatt  aaacagctg  tgctaccaa  ctttgttcc  60
gagatctgt  cgcggctac  tcgcagctt  ctgcagccc  aagggaagg  gatgagttg  120
ttgatccac  caagctgaa  ccagacaga  cattcgcct  acaggacct  ttccctctt  180
tggtacctt  tggagggaa  acagaagcc  aatgttttg  gcagaaagc  ggggagggc  240
ggaggtctc  agggagagg  tgaaatgcc  cagcaaggt  tctgcacca  gcatcccaa  300
gaggcatag  agagaccac  actgttggg  ctcaaactc  actttggat  tgccttgag  360
atcgccctg  aaaggccct  gaattctaa  agacagcgt  atatacaga  ttagcactc  420
ttttttttc  tccggagct  aggaccgaa  ccagggcct  gcacttgct  ggcaagcgc  480
ctaccactg  gctaaaacc  caacccgta  tatacagac  ttaattaat  ctctggtca  540
ttagcactt  aggtgtccg  gggtgtagg  cagaagcct  cacttcagg  gtggataag  600
tactgcctt  ctacgtaag  acc  623



<210> 4631
<211> 569
<212> DNA
<213> Rattus norvegicus
<308> AA800268
<400> 4631

caaatttca  ccataactg  aagacttta  tttaagaaa  atttacagc  aaacagaac  60
tgaagttag  gggtttaga  gatatggca  aacataatt  ccagaaaag  tgcccaagc  120
ttgatggct  cttgctaga  agaggagag  gagtggcag  ccctaacct  actcacctt  180
cctgattca  agaaccttg  cccttttaa  gctgggccc  ggaacccca  tttccaatt  240
ctcccttct  ggagtttag  aaggtttat  ttatctgtc  ggcttccaa  atacagaag  300
tagtacgga  aagggaaaa  cattctatt  gttccagtg  cttccctca  tgcctgcag  360
cctatcagc  cgtctttca  tatttgttg  ttccaaaga  gcgaacccc  tgggactgg  420
gcagcttag  cagcagtac  ctgagcagt  aggcagtgt  gatgaggaa  tgagcagca  480
catacttgg  gtagaagct  gccagtagg  anagtacaa  aggggaaat  ctgaggaac  540
ttcgtgagg  agtaaactg  agtccgtag  569



<210> 4632
<211> 153
<212> PRT
<213> Rattus norvegicus
<308> AAH02146
<400> 4632

Met Asn Val Gly Val Ala His Ser Glu Val Asn Pro Asn Thr Arg Val 
  1               5                  10                  15
Met Asn Ser Arg Gly Ile Trp Leu Ala Tyr Ile Ile Leu Val Gly Leu 
             20                  25                  30
Leu His Val Val Leu Leu Ser Ile Pro Phe Phe Ser Ile Pro Val Val 
         35                  40                  45
Trp Thr Leu Thr Asn Val Ile His Asn Leu Ala Met Tyr Ile Phe Leu 
     50                  55                  60
His Thr Val Lys Gly Thr Pro Phe Glu Thr Pro Asp Gln Gly Lys Ala 
 65                  70                  75                  80
Arg Leu Leu Thr His Trp Glu Gln Met Asp Tyr Gly Leu Gln Phe Thr 
                 85                  90                  95
Ser Ser Arg Lys Phe Leu Ser Ile Ser Pro Ile Val Leu Tyr Leu Leu 
             100                105                110
Ala Ser Phe Tyr Thr Lys Tyr Asp Ala Ala His Phe Leu Ile Asn Thr 
         115                120                125
Ala Ser Leu Leu Ser Val Leu Leu Pro Lys Leu Pro Gln Phe His Gly 
     130                135                140
Val Arg Leu Phe Gly Ile Asn Lys Tyr 
 145                150



<210> 4633
<211> 625
<212> DNA
<213> Rattus norvegicus
<308> AA800272
<400> 4633

aagagagat  aatctttaa  aaaactata  accaaaaca  gactgggaa  tgtgtctaa  60
gaatgacac  acaaacggc  ggcagcttg  tctttacaa  ctgtcaatg  taacaaacc  120
agtctatgt  actgttaat  cagtaacct  gctaatcag  ctgaagagg  gccaagtgg  180
tcacttgtg  ccttggtgg  cacaggagc  tgctctcat  actaagcac  gggaacgac  240
tcccactcc  ggttctatt  ctgatctgg  caccaaagt  cgcggagca  agaggcctg  300
agcaccagc  catcaggca  aggtgatgg  aggttcgct  ggctgccac  cgctctcat  360
gtacagatc  tctggaagt  cttcttcgt  tccatcagg  aagtaggta  ggaacggca  420
gctcttaca  aaatccttg  atgcaggca  cgtanagtc  ttgatcttc  ctaagcaat  480
tctatgtcc  ggcacagag  cattgacat  gattatatt  tgcttggtg  tcactctcc  540
caccttcag  ccatacact  tcctgtttt  gtttcccat  tgcccgggc  ttttagttc  600
aggccagac  ctggcaata  cccca  625



<210> 4634
<211> 1634
<212> DNA
<213> Homo sapiens
<308> X06323
<400> 4634

ggtggcgtg  ggactccct  aaagcagag  ggcagggcg  ccggaagtc  tgagtcgag  60
cttcccggg  taatccatg  cgggttgga  gctgctgac  caggtcggc  cccaggtgc  120
gggtcgact  ggggacggc  tgggtgctg  cctgggccc  gggaacaga  cacacatct  180
gctttttgt  agaggtctt  atggaaaga  tggtacatg  tgggatgag  atctttctg  240
agaaaatgt  ccattcatt  agcagttgg  ctctgatga  gataaagcc  aattagcaa  300
taaactgtg  cctctgaaa  atgaaccat  gcctataca  ccttgggaa  caggttcct  360
tagagttgg  cttattgcc  tgaagctgg  catgatgcc  ttatggacc  aggatggtc  420
aaagcatgt  gtcacatta  ttcaggtac  agactgtca  gtcttaaaa  atacgtcaa  480
ggaaaactg  aatggaaaa  tggcaaccc  gtctgtagg  ggaaaaact  tatcacgtt  540
tcgtaaagc  acatccata  tggaatttt  ccgggaact  ggattgccg  cgaaacaga  600
agttaaaat  tttaatata  cagataatg  tgcaattaa  ccaggcact  ctctttatg  660
tgctcactt  cgtccagga  agtatgtgg  tgtcacagc  aaaactatt  gtaaaggtt  720
tcaaggtgt  atgaaaaga  ggggattta  aggccagcc  gctacgcat  gtcaaacga  780
aacccacag  agacctgga  ctgttgcaa  tggtgatat  ggcagagtc  ggcctggaa  840
taaaatgcc  ggaaaaatg  gaaacatat  caggacaga  tatggactg  aagtgtgga  900
aataaacac  aagcacaac  taatctatg  aaatggctc  gtacctgga  ataaaaatt  960
cttagtaaa  gtcaaagat  ctaaactgc  tgcatataa  gatctcggt  aaaatctac  1020
attccctac  tattttcct  atggagatg  agaggaact  ccagaagat  tgtatgatg  1080
aaacgtgtg  cagcccggt  cgccttcta  tacatttgc  taacatctt  ggacgtggc  1140
gaaccttac  tattctgtg  gcttcgatg  gccagagtg  tatcataac  accagaaat  1200
atactctcc  ttcttagtc  caacaaaat  acacatgtc  tctttgtca  gggcataaa  1260
atatcattc  tacccccat  aaattttgt  agaaaaatt  ccacattaa  tatatgagt  1320
aagtagatt  gatttgctg  aattggtgt  gggcatatt  gcaaaatat  cttaatttg  1380
ggactcgat  cttttttac  acatatttc  caagttatc  taagatgtc  gtaaattta  1440
cttttatta  agttttgtc  atctttgtg  aatagtggt  gtggaacag  agaaaacca  1500
atggggact  tagtgcaac  tatttgggt  aagaaacca  ttgctaaaa  ggagaaagt  1560
aatagattt  tatttaaat  acagaaaca  gttaaaggc  ggacaaagg  aagacaata  1620
aatcataaa  tatc  1634



<210> 4635
<211> 348
<212> PRT
<213> Homo sapiens
<308> P09001
<400> 4635

Met Pro Gly Trp Arg Leu Leu Thr Gln Val Gly Ala Gln Val Leu Gly 
  1               5                  10                  15
Arg Leu Gly Asp Gly Leu Gly Ala Ala Leu Gly Pro Gly Asn Arg Thr 
             20                  25                  30
His Ile Trp Leu Phe Val Arg Gly Leu His Gly Lys Ser Gly Thr Trp 
         35                  40                  45
Trp Asp Glu His Leu Ser Glu Glu Asn Val Pro Phe Ile Lys Gln Leu 
     50                  55                  60
Val Ser Asp Glu Asp Lys Ala Gln Leu Ala Ser Lys Leu Cys Pro Leu 
 65                  70                  75                  80
Lys Asp Glu Pro Trp Pro Ile His Pro Trp Glu Pro Gly Ser Phe Arg 
                 85                  90                  95
Val Gly Leu Ile Ala Leu Lys Leu Gly Met Met Pro Leu Trp Thr Lys 
             100                105                110
Asp Gly Gln Lys His Val Val Thr Leu Leu Gln Val Gln Asp Cys His 
         115                120                125
Val Leu Lys Tyr Thr Ser Lys Glu Asn Cys Asn Gly Lys Met Ala Thr 
     130                135                140
Leu Ser Val Gly Gly Lys Thr Val Ser Arg Phe Arg Lys Ala Thr Ser 
 145                150                155                160
Ile Leu Glu Phe Tyr Arg Glu Leu Gly Leu Pro Pro Lys Gln Thr Val 
                 165                170                175
Lys Ile Phe Asn Ile Thr Asp Asn Ala Ala Ile Lys Pro Gly Thr Pro 
             180                185                190
Leu Tyr Ala Ala His Phe Arg Pro Gly Gln Tyr Val Asp Val Thr Ala 
         195                200                205
Lys Thr Ile Gly Lys Gly Phe Gln Gly Val Met Lys Arg Trp Gly Phe 
     210                215                220
Lys Gly Gln Pro Ala Thr His Gly Gln Thr Lys Thr His Arg Arg Pro 
 225                230                235                240
Gly Ala Val Ala Thr Gly Asp Ile Gly Arg Val Trp Pro Gly Thr Lys 
                 245                250                255
Met Pro Gly Lys Met Gly Asn Ile Tyr Arg Thr Glu Tyr Gly Leu Lys 
             260                265                270
Val Trp Arg Ile Asn Thr Lys His Asn Ile Ile Tyr Val Asn Gly Ser 
         275                280                285
Val Pro Gly His Lys Asn Cys Leu Val Lys Val Lys Asp Ser Lys Leu 
     290                295                300
Pro Ala Tyr Lys Asp Leu Gly Lys Asn Leu Pro Phe Pro Thr Tyr Phe 
 305                310                315                320
Pro Asp Gly Asp Glu Glu Glu Leu Pro Glu Asp Leu Tyr Asp Glu Asn 
                 325                330                335
Val Cys Gln Pro Gly Ala Pro Ser Ile Thr Phe Ala 
             340                345



<210> 4642
<211> 569
<212> DNA
<213> Rattus norvegicus
<308> AA800303
<400> 4642

aatccaaat  gtatagatt  tacgttggc  aactctagc  tagcaggcg  cactccctt  60
gttatccca  gtccacccc  tcccgtcac  gctgtcttc  actgtttaa  aagttgcaa  120
gttggggct  gggatttag  tcagtggta  agcgcttac  taggaagcg  aaggccctg  180
gtgcggtcc  cggctccga  aaaaagaac  aaaaaaaaa  aaaaaaaag  tgcaaagtt  240
atatgagta  aacatacaa  gacacagcc  ccttcctac  gtaggggaa  gaaggggtt  300
acagttaaa  aaggcacag  aagctgcag  aagcaccag  agggcccag  ggttagggg  360
tggcactgg  tcccagccc  acagctatt  gtggggagg  agggatccc  tcagagtgc  420
accgtctga  gctaaacta  ttggctaaa  tgctaaaag  taagggtgg  atctgccat  480
tttggtgcc  cttgccttt  acccacagg  cctgctgta  aacttgagt  ctggattcc  540
gaggccccc  cctgtgcag  ggccctgga  569



<210> 4643
<211> 296
<212> PRT
<213> Rattus norvegicus
<308> NP_076053
<400> 4643

Met Ala Gly Tyr Leu Pro Pro Lys Gly Tyr Ala Pro Ser Pro Pro Pro 
  1               5                  10                  15
Pro Tyr Pro Val Pro Ser Gly Tyr Pro Glu Pro Val Ala Leu His Pro 
             20                  25                  30
Gly Pro Gly Gln Ala Pro Val Pro Thr Gln Val Pro Ala Pro Ala Pro 
         35                  40                  45
Gly Phe Ala Leu Phe Pro Ser Pro Gly Pro Val Ala Pro Gly Pro Pro 
     50                  55                  60
Ala Pro Phe Val Pro Leu Pro Gly Val Pro Pro Gly Leu Glu Phe Leu 
 65                  70                  75                  80
Val Gln Ile Asp Gln Ile Leu Ile His Gln Lys Ala Glu Arg Val Glu 
                 85                  90                  95
Thr Phe Leu Gly Trp Glu Thr Cys Asn Met Tyr Glu Leu Arg Ser Gly 
             100                105                110
Thr Gly Gln Gln Leu Gly Gln Ala Ala Glu Glu Ser Asn Cys Cys Ala 
         115                120                125
Arg Leu Cys Cys Gly Ala Arg Arg Pro Phe Arg Ile Arg Leu Ala Asp 
     130                135                140
Pro Gly Asp Arg Glu Val Leu Arg Leu Leu Arg Pro Leu His Cys Gly 
 145                150                155                160
Cys Ser Cys Cys Pro Cys Gly Leu Gln Glu Met Glu Val Gln Ala Pro 
                 165                170                175
Pro Gly Thr Thr Ile Gly His Val Leu Gln Thr Trp His Pro Phe Leu 
             180                185                190
Pro Lys Phe Ser Ile Leu Asp Ala Asp Arg Gln Pro Val Leu Arg Val 
         195                200                205
Val Gly Pro Cys Trp Thr Cys Gly Cys Gly Thr Asp Thr Asn Phe Glu 
     210                215                220
Val Lys Thr Lys Asp Glu Ser Arg Ser Val Gly Arg Ile Ser Lys Gln 
 225                230                235                240
Trp Gly Gly Leu Leu Arg Glu Ala Leu Thr Asp Ala Asp Asp Phe Gly 
                 245                250                255
Leu Gln Phe Pro Val Asp Leu Asp Val Lys Val Lys Ala Val Leu Leu 
             260                265                270
Gly Ala Thr Phe Leu Ile Asp Tyr Met Phe Phe Glu Lys Arg Gly Gly 
         275                280                285
Ala Gly Pro Ser Ala Ile Thr Ser 
     290                295



<210> 4645
<211> 295
<212> PRT
<213> Homo sapiens
<308> Q9NRY6
<400> 4645

Met Ala Gly Tyr Leu Pro Pro Lys Gly Tyr Ala Pro Ser Pro Pro Pro 
  1               5                  10                  15
Pro Tyr Pro Val Thr Pro Gly Tyr Pro Glu Pro Ala Leu His Pro Gly 
             20                  25                  30
Pro Gly Gln Ala Pro Val Pro Ala Gln Val Pro Ala Pro Ala Pro Gly 
         35                  40                  45
Phe Ala Leu Phe Pro Ser Pro Gly Pro Val Ala Leu Gly Ser Ala Ala 
     50                  55                  60
Pro Phe Leu Pro Leu Pro Gly Val Pro Ser Gly Leu Glu Phe Leu Val 
 65                  70                  75                  80
Gln Ile Asp Gln Ile Leu Ile His Gln Lys Ala Glu Arg Val Glu Thr 
                 85                  90                  95
Phe Leu Gly Trp Glu Thr Cys Asn Arg Tyr Glu Leu Arg Ser Gly Ala 
             100                105                110
Gly Gln Pro Leu Gly Gln Ala Ala Glu Glu Ser Asn Cys Cys Ala Arg 
         115                120                125
Leu Cys Cys Gly Ala Arg Arg Pro Leu Arg Val Arg Leu Ala Asp Pro 
     130                135                140
Gly Asp Arg Glu Val Leu Arg Leu Leu Arg Pro Leu His Cys Gly Cys 
 145                150                155                160
Ser Cys Cys Pro Cys Gly Leu Gln Glu Met Glu Val Gln Ala Pro Pro 
                 165                170                175
Gly Thr Thr Ile Gly His Val Leu Gln Thr Trp His Pro Phe Leu Pro 
             180                185                190
Lys Phe Ser Ile Gln Asp Ala Asp Arg Gln Thr Val Leu Arg Val Val 
         195                200                205
Gly Pro Cys Trp Thr Cys Gly Cys Gly Thr Asp Thr Asn Phe Glu Val 
     210                215                220
Lys Thr Arg Asp Glu Ser Arg Ser Val Gly Arg Ile Ser Lys Gln Trp 
 225                230                235                240
Gly Gly Leu Val Arg Glu Ala Leu Thr Asp Ala Asp Asp Phe Gly Leu 
                 245                250                255
Gln Phe Pro Leu Asp Leu Asp Val Arg Val Lys Ala Val Leu Leu Gly 
             260                265                270
Ala Thr Phe Leu Ile Asp Tyr Met Phe Phe Glu Lys Arg Gly Gly Ala 
         275                280                285
Gly Pro Ser Ala Ile Thr Ser 
     290                295



<210> 4646
<211> 556
<212> DNA
<213> Rattus norvegicus
<308> AA800305
<400> 4646

ttttacacc  ctttattcc  acctgagca  ctcaatata  aactaaaca  tggtgagct  60
ttctcctta  taattttga  ttactgtaa  atgtacaca  tctgctagc  gatcaacac  120
taaatagat  aaatcatct  acacatggt  gatttcata  aatgaaaat  cctaaaata  180
ttagtgcaa  atactgatt  aaataaaat  gacttcaaa  aacaaggct  caagattac  240
aataacatt  taatactta  gttacaaat  gcaagtacg  tgtttatta  ggttctagc  300
tgtaagaac  gcaaagccc  ttcctttca  agggggaga  agaaataat  agctgtttt  360
gtaactgta  attttgtat  tttaggcaa  tcttaaata  tacaggaaa  aataaacat  420
tggagacta  aatgcagta  tctatttac  gtacagctg  atatttaaa  taatcaagt  480
tgaatgtac  taatggtta  tgcactgac  aatcatgtc  aaagggaag  agagccccc  540
ccctgttct  gcctcg  556



<210> 4647
<211> 560
<212> DNA
<213> Rattus norvegicus
<308> AA800318
<400> 4647

gaaagtgtc  gcaagtttt  tttgtagac  ctgttaagc  tgaaccata  aagctgcaa  60
acagtggtt  agagagcat  tcaatacca  gggggttgg  gggtggaaa  tgttccttc  120
gccagttcc  aaggctgga  gtggctagg  caggcagtg  cgaggaaat  gctggatga  180
ctgaagctt  ggtggcagt  cttactcaa  cctgactcc  gcctgtctc  ggccctggg  240
tcatataca  ggcccatga  gactgggaa  ttgtgtcgc  ggtcccaga  caggaagag  300
aaaggctgc  gcacctcaa  gatgagtaa  tttcgggcc  cggagatgg  ggaggctgc  360
gctgcttcc  cacctgtct  tgtcagttc  aacaccgtc  cgtgtttca  ggaagacac  420
tgaagatct  ggtcctcag  cagcccaca  aggttgaga  cgtaagtga  gtcaaagaa  480
tccagtttc  ccatgattg  cagcatgtc  tggatgctc  ttactttaa  gcgaggcat  540
atcacgtaa  tgggctgaaa  560



<210> 4648
<211> 418
<212> PRT
<213> Rattus norvegicus
<308> B26423
<400> 4648

Met Thr Arg Leu Val Thr Leu Glu Leu Leu Met Ala Gly Ile Gly Ser 
  1               5                  10                  15
Ala Leu Leu Cys Phe Pro Asp Cys Ile Leu Gly Glu Asp Thr Leu Phe 
             20                  25                  30
His Glu Asp Gln Asp Lys Gly Thr Gln Leu Asp Ser Leu Thr Leu Ala 
         35                  40                  45
Ser Ile Asn Thr Asp Phe Ala Phe Ser Leu Tyr Lys Lys Leu Ala Leu 
     50                  55                  60
Arg Asn Pro Asp Lys Asn Val Val Phe Ser Pro Leu Ser Ile Ser Ala 
 65                  70                  75                  80
Ala Leu Ala Val Val Ser Leu Gly Ala Lys Gly Asn Ser Met Glu Glu 
                 85                  90                  95
Ile Leu Glu Gly Leu Lys Phe Asn Leu Thr Glu Thr Pro Glu Thr Glu 
             100                105                110
Ile His Arg Gly Phe Gly His Leu Leu Gln Arg Leu Ser Gln Pro Arg 
         115                120                125
Asp Glu Ile Gln Ile Ser Thr Gly Asn Ala Leu Phe Ile Glu Lys Arg 
     130                135                140
Leu Gln Val Leu Ala Glu Phe Gln Glu Lys Ala Lys Ala Leu Tyr Gln 
 145                150                155                160
Ala Glu Ala Phe Thr Ala Asp Phe Gln Gln Ser Arg Glu Ala Lys Lys 
                 165                170                175
Leu Ile Asn Asp Tyr Val Ser Lys Gln Thr Gln Gly Lys Ile Gln Gly 
             180                185                190
Leu Ile Thr Asn Leu Ala Lys Lys Thr Ser Met Val Leu Val Asn Tyr 
         195                200                205
Ile Tyr Phe Lys Gly Lys Trp Lys Val Pro Phe Asp Pro Arg Asp Thr 
     210                215                220
Phe Gln Ser Glu Phe Tyr Ser Gly Lys Arg Arg Pro Val Lys Val Pro 
 225                230                235                240
Met Met Lys Leu Glu Asp Leu Thr Thr Pro Tyr Val Arg Asp Glu Glu 
                 245                250                255
Leu Asn Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn Ala Ser Ala 
             260                265                270
Leu Phe Ile Leu Pro Asp Gln Gly Lys Met Gln Gln Val Glu Ala Ser 
         275                280                285
Leu Gln Pro Glu Thr Leu Arg Arg Trp Lys Asp Ser Leu Arg Pro Ser 
     290                295                300
Met Ile Asp Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser Ala Asp Tyr 
 305                310                315                320
Asn Leu Glu Asp Val Leu Pro Glu Leu Gly Ile Lys Glu Val Phe Ser 
                 325                330                335
Thr Gln Ala Asp Leu Ser Gly Ile Thr Gly Asp Lys Asp Leu Met Val 
             340                345                350
Ser Gln Val Val His Lys Ala Val Leu Asp Val Ala Glu Thr Gly Thr 
         355                360                365
Glu Ala Ala Ala Ala Thr Gly Val Lys Phe Val Pro Met Ser Ala Lys 
     370                375                380
Leu Asp Pro Leu Ile Ile Ala Phe Asp Arg Pro Phe Leu Met Ile Ile 
 385                390                395                400
Ser Asp Thr Glu Thr Ala Ile Ala Pro Phe Leu Ala Lys Ile Phe Asn 
                 405                410                415
Pro Lys 
             420



<210> 4649
<211> 657
<212> DNA
<213> Homo sapiens
<308> M13203
<400> 4649

ctcggaccc  gtacagcag  agccccaga  tcctaagca  caacagtga  gccaacttg  60
agctcatca  cacctgggt  gccaagaac  ccaacaaca  gatcagccg  ctgctagac  120
gtctgccct  cgatacccg  cttgtcctc  tcaatgcta  ctacctgag  gccaagtgg  180
agacaacat  tgatcccaa  aaaaccaga  tggaaccct  tcagcttca  aaactcagt  240
ataaaatgc  catgatgaa  agcaagaag  accctctgg  ccatttcat  gaccaaact  300
tgaaagcca  ggtggggca  ctgcagctc  cccacaatc  gagtttggt  atcctggta  360
cccagaacc  gaaacatcg  cttgaagac  ctggaacag  ctctcagcc  tctgttttc  420
aggccatca  ggagaaact  gagatgtcc  agttccagc  aactctcct  acactaccc  480
gcatcaaag  gacgaccag  caggatatg  tctcaatca  ggagaaatt  gttttcttc  540
atttttctt  tgaccttaa  ctgtgtggg  tgacagagg  cccagatct  caggttttc  600
cgatgcagc  ccagacagt  ctggaactg  cagagactg  ggtggaggc  gctgcag  657



<210> 4650
<211> 500
<212> PRT
<213> Homo sapiens
<308> ITHUC1
<400> 4650

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
  1               5                  10                  15
Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
             20                  25                  30
Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
         35                  40                  45
Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
     50                  55                  60
Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
 65                  70                  75                  80
Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                 85                  90                  95
Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
             100                105                110
Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
         115                120                125
Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
     130                135                140
Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
 145                150                155                160
Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                 165                170                175
Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
             180                185                190
Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
         195                200                205
Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
     210                215                220
Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
 225                230                235                240
Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                 245                250                255
Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
             260                265                270
Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
         275                280                285
Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
     290                295                300
Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
 305                310                315                320
Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                 325                330                335
Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
             340                345                350
Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
         355                360                365
Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
     370                375                380
Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
 385                390                395                400
Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                 405                410                415
Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
             420                425                430
Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
         435                440                445
Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
     450                455                460
Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
 465                470                475                480
Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                 485                490                495
Asp Pro Arg Ala 
             500



<210> 4651
<211> 567
<212> DNA
<213> Rattus norvegicus
<308> AA800535
<400> 4651

gaaagaatg  ttttttttt  ttaaaaaat  aaacatgag  acttttttt  ttctctgca  60
tgctcagcc  tttttctga  gacataaaa  agttttaag  gttttggcc  aaacattcc  120
gagagcgga  gggagtgct  tgatgtggt  tgagtggca  tgctggtca  ggtccttca  180
accacatac  ggtacgggt  tgccttccc  tggtctggt  tggcaaagg  gctggccca  240
cctaaagag  aagggtggc  aaaaacggc  ttcatgttc  tccactttg  ttttttagc  300
catcttctc  cttcctttt  caattgttc  attcccgtc  catctgtgc  gatggagtg  360
acttgggtc  caaacatca  tgatgtgaa  atgaggaag  gcagggcct  aaaacacag  420
aggatgagc  ggataacag  ggtgggcgg  gagaaggag  tgcactttg  ccagtcttc  480
tcaaagcaa  gcaggaagt  gaatcccac  atgatgagg  cgtgcaagg  aatgagagc  540
atgtacatt  tgaacagga  anagtac  567



<210> 4652
<211> 2720
<212> DNA
<213> Homo sapiens
<308> AF247703
<400> 4652

gctcgatgg  cttctcctg  gcgccgccc  gtgtctggc  gagtccaga  agccgcggc  60
cctcgttcc  aggagccat  gccgaagcc  gaggccggg  cccgggttg  ggactgcag  120
ggaaggcag  ggcggcggc  gcgggagcc  caccggggt  tgggactgg  gaactgcct  180
cggcttcac  atgccagta  ggacagaat  gcttatgat  cttatcccc  cccaccact  240
ccgaaacat  gagcggaaa  cagaatacc  ccagccaga  aagtgtgtc  cacccccct  300
ccctggtcc  gtgggaacc  tgtggttta  ccgtgacgg  tgtggcatc  cctgtgcca  360
cgttacctg  tttctggtc  tctatgcgg  gttcgtggt  ctctttgtc  tgctgattc  420
atctcgaga  tacgtgtat  gcatcatca  cggaattgt  ttcaacctg  tggccttct  480
ggccctggc  tcccactgc  gggccatgc  gacggaccc  ggggcagtg  ccaaaggaa  540
tgccactaa  gaattcatc  agagtttac  gttgaagcc  gggcaggtg  tgtacaagt  600
ccccaaatg  tgcagcatc  agcccgacc  agcccacca  tgcagtgtt  gtaagcggt  660
cattcggaa  atggaccac  actgtccct  ggtcaacaa  tgtgtaggc  agaacaacc  720
gaagtactt  gtcctgttt  caatgtaca  agctctcat  tccttgcac  ccctcatca  780
ggtgggatt  cacttcctg  attgctttg  agaagattg  acaacctat  gactgaaca  840
ggaagaaat  gcagagact  gaatctctc  tcatgaaaa  atgcagccc  ttaacttca  900
ttcgacaga  tgcagctcc  tctctccac  caccacagt  attctcctt  tcctgctgt  960
ctttgaggg  ctgctcttc  tcattttca  atcagtgat  tttgggacc  aggtgcact  1020
catctgcac  gatgagacg  gaatagaac  attgaaaaa  gaagagaga  gatgggcta  1080
aaaaacaaa  tggatgaac  tgaaagccg  ttttggcca  cccttctct  taggctggg  1140
cagcccctt  gccacgcca  accaaggga  ggcagaccc  taccagtat  tggtctgaa  1200
gaccccgac  ggcatggcc  ctcagacac  agtccacac  acagcacta  cgtcccatc  1260
gttctcatg  atgtttaaa  cgaaaaagc  aaacaacta  tcttaaaac  ttttttatg  1320
ctcaagtaa  atggctgag  attgcagag  aaaaaaaaa  tccccacat  ttatttttt  1380
aaaaccatc  tttcgattt  ttttggtga  cgaagctgc  ctcttttcc  tttaaaatc  1440
cttctctgg  ctctggttt  tctctgctg  ctgtctggc  tgactaatg  agagggcgc  1500
gtctcgcgc  gtgcccatt  tactaactg  gtgagacat  acgctgtgc  tggatggaa  1560
agtctggac  cctggtggg  gatgcatgg  aaagccagg  gggccctga  ctcccactg  1620
ccaggaggc  gtggcgggc  ccccgatgg  acataaaac  tcaccgaag  tggatgctt  1680
ccccttgag  cctgagaag  gcaggatca  aagggacct  ggcacagcg  cctcatccc  1740
caagtggac  cggtttgcc  gctaactcg  aaagcaatt  cctgccttg  actttatgg  1800
cttggggtg  gtagaatga  tttgcgggg  agtggggag  aagatgaaa  aggtcttat  1860
tgtattctg  atcagcaat  atattccct  tgattattt  gaagagtgt  taggaaaga  1920
gtttttcca  ttcaaaatg  cttatacaa  caagaggaa  aaaaattac  caatttcag  1980
caagctacg  tttcctttg  ttcatctgc  tcctctctc  ccaccccat  tccctctct  2040
ccccagcaa  atgtcaatt  agcagtgtg  attctgact  caataggca  cagtgccca  2100
cacatacag  cccaccatc  tccccttct  attttataa  cctcaaagt  gattcactt  2160
ctgatagtt  acccccata  atgtgcacg  acctgtgtc  tatctatat  ttaacctgg  2220
agactgttg  cctggcatg  agatgacca  gatgctggg  ttacctcac  gtccccacc  2280
tttcaaagt  gacatatgg  catcccatt  gccagaatc  acagacaca  ctaagcctg  2340
ggcactggg  cagaataga  tttccattt  agaggcact  cctgtgtca  tcttgtttg  2400
aggaggtgg  gatggtgga  agaggtgaa  gaggtaggg  gtgccctcc  agtgcaaaa  2460
taacaaata  gattattga  catcgggga  ttctcacac  ttgatttgt  ttttaagca  2520
ttgccagaa  ccccctttt  tagcttttg  ttggggtgg  ggtaggagt  aaggtttat  2580
caatcctgt  ctgggtagg  cgaaagtta  tctagccat  tgatttttc  gaaaagtaa  2640
tggaacatg  tgccacttt  caattctgt  agtgcttcc  catggaaac  aaatgcaat  2700
aaatttttc  aaaacctgat  2720



<210> 4653
<211> 328
<212> PRT
<213> Homo sapiens
<308> AF247703
<400> 4653

Met Met Leu Ile Pro Thr His His Phe Arg Asn Ile Glu Arg Lys Pro 
  1               5                  10                  15
Glu Tyr Leu Gln Pro Glu Lys Cys Val Pro Pro Pro Tyr Pro Gly Pro 
             20                  25                  30
Val Gly Thr Met Trp Phe Ile Arg Asp Gly Cys Gly Ile Ala Cys Ala 
         35                  40                  45
Ile Val Thr Trp Phe Leu Val Leu Tyr Ala Glu Phe Val Val Leu Phe 
     50                  55                  60
Val Met Leu Ile Pro Ser Arg Asp Tyr Val Tyr Ser Ile Ile Asn Gly 
 65                  70                  75                  80
Ile Val Phe Asn Leu Leu Ala Phe Leu Ala Leu Ala Ser His Cys Arg 
                 85                  90                  95
Ala Met Leu Thr Asp Pro Gly Ala Val Pro Lys Gly Asn Ala Thr Lys 
             100                105                110
Glu Phe Ile Glu Ser Leu Gln Leu Lys Pro Gly Gln Val Val Tyr Lys 
         115                120                125
Cys Pro Lys Cys Cys Ser Ile Lys Pro Asp Arg Ala His His Cys Ser 
     130                135                140
Val Cys Lys Arg Cys Ile Arg Lys Met Asp His His Cys Pro Trp Val 
 145                150                155                160
Asn Asn Cys Val Gly Glu Asn Asn Gln Lys Tyr Phe Val Leu Phe Thr 
                 165                170                175
Met Tyr Ile Ala Leu Ile Ser Leu His Ala Leu Ile Met Val Gly Phe 
             180                185                190
His Phe Leu His Cys Phe Glu Glu Asp Trp Thr Thr Tyr Gly Leu Asn 
         195                200                205
Arg Glu Glu Met Ala Glu Thr Gly Ile Ser Leu His Glu Lys Met Gln 
     210                215                220
Pro Leu Asn Phe Ser Ser Thr Glu Cys Ser Ser Phe Ser Pro Pro Thr 
 225                230                235                240
Thr Val Ile Leu Leu Ile Leu Leu Cys Phe Glu Gly Leu Leu Phe Leu 
                 245                250                255
Ile Phe Thr Ser Val Met Phe Gly Thr Gln Val His Ser Ile Cys Thr 
             260                265                270
Asp Glu Thr Gly Ile Glu Gln Leu Lys Lys Glu Glu Arg Arg Trp Ala 
         275                280                285
Lys Lys Thr Lys Trp Met Asn Met Lys Ala Val Phe Gly His Pro Phe 
     290                295                300
Ser Leu Gly Trp Ala Ser Pro Phe Ala Thr Pro Asp Gln Gly Lys Ala 
 305                310                315                320
Asp Pro Tyr Gln Tyr Val Val Ter 
                 325



<210> 4654
<211> 496
<212> DNA
<213> Rattus norvegicus
<308> AA800570
<400> 4654

cacctgaaa  ataaaactt  taaaaaata  acaggactt  taaagtaca  gtatatctt  60
aatggctga  ttataaata  tgtctctgg  catgttcac  gctagggct  gagaaaatg  120
cccaattcc  gtgaaggct  atagagtca  gaggccagc  ggaccacaa  tggtcttgc  180
gaactcttt  atccaaagt  gatttaaac  gtccataaa  cagggtcag  aggggaaga  240
gaatggact  ccagacact  tcccacgag  ccagaggat  cttggaata  gagatcaat  300
tacaaatta  taaactata  gactaagaa  tcacaccat  aatataaat  acaggctat  360
attgaagat  caaagtggc  ttttatgtt  catcccccc  gtctctcat  aaaaattta  420
aaagtcccc  tgggcttcc  aatgactta  gtcctcatc  gctgtgaag  aatctccaa  480
cccagacac  ttgggg  496



<210> 4655
<211> 495
<212> DNA
<213> Homo sapiens
<308> R49498
<400> 4655

ttttttttt  tttttaggc  gagttctta  gatgtattt  tgttcacct  aaaaataaa  60
ctttttaaa  atatacagg  ctttttgag  acaggtata  cttaaatgg  tgaattata  120
ataatgtct  tggtcatgt  cacagctag  gctggagca  atgtcccaa  tccagtgaa  180
gctttggag  gtcaggagg  cagcagctg  gacctatga  tgggcctct  taggactct  240
tgatccatc  caaagagga  ttaaacagt  caggaaagg  aggggatca  ggaaggagg  300
acaggggaa  tgggacttc  caggatgtt  cttacaagt  tcaaaggga  ttcttggga  360
ttaaggaga  ccaatttta  caaatttnt  ttaaaatta  agggggctt  aaaaatttc  420
accccagtt  aatttttaa  tttaccggg  ttttttttn  aggtttgtt  aagtngggc  480
tttttttgg  ttncg  495



<210> 4656
<211> 473
<212> DNA
<213> Rattus norvegicus
<308> AA800572
<400> 4656

gaagtagtg  tatgttata  tcagacatg  gtacatttc  acagtcttt  gcaataaat  60
tcataaaat  atagagatt  gcataataa  tattcttta  aataaaaaa  agtttaaca  120
acttttgtc  taaaaatag  caggattca  ctttgtgtt  tatacataa  atatacaaa  180
agcaccaca  tttgtggtt  aggcaatga  aacacagga  gggttggaa  tgctcagct  240
ttaaagagt  aaaaggcca  ccaggagcc  aaggcacct  agggagctg  ggctgagac  300
ccggggcag  tcagatagg  atgtcaact  cggtgtcca  gcgccccct  agtgaagtg  360
ggggtgcga  gggaaggcc  tcacggata  tgggtgctg  aggaggaga  aggagggtt  420
ccaacatca  ctctgatgt  aagaccaac  ccgcacagt  aatccagag  tgt  473



<210> 4657
<211> 1604
<212> DNA
<213> Homo sapiens
<308> AF041037
<400> 4657

tgtgaacag  gtgggaagt  caagtgtgg  gaatgcact  ctcccagga  cctaccatc  60
tgtttggcc  gtaaccggc  gtgcctttg  tctgctgag  gcatggtgg  atatggaac  120
tgcatgtgc  tagtcaagg  catcttcta  cactgctcc  atgacgacg  aggggattc  180
tattcagat  atccttgct  ctgttcaca  tcacactgc  gctctagat  cctgtgtat  240
ggagccatg  ctttatttt  accttgctt  ctctgttat  ctcctgcta  aggatgcct  300
aagctgtgc  ggaggtgtt  tgactggat  catcgccca  ggtgcagat  taagaactc  360
aacactgtc  attgtaagc  ggagagctg  ccctcccgg  gtcagggta  accatcatg  420
tttttggag  tgggttgta  ctcctgaac  tttagcttt  aagttgtgg  tgttttttg  480
tttgttttg  ttgttttct  taaattttc  gttccctcc  tcccctgtt  ccaaggtct  540
actcatgga  ttttctctt  cctcatgga  gatcttcag  aagagtgga  tgggaagct  600
cacctggct  ccactttca  caagagcct  tgccatcca  ttgagggta  tgagagcca  660
tgggctttt  tgtaccttt  tgttctgca  gcaactttc  aaagttgtg  acatgaaca  720
acacccaca  ccagaacag  gatttagag  tgttttgat  gggtaccgt  ggagcaggg  780
aattggttt  ttaaaaagc  actgtttaa  tgcttaaat  agctatgta  taaatctgt  840
tccagttag  gctatcttc  tagcatagg  cccttaagt  gcatggggg  attttgtat  900
acgtaaaaa  ttcctttaa  cactgccct  tccttcttt  ccttcaagg  ttttccccc  960
cagtttgtt  ttgtcttat  ggagatgcc  agtgatttt  tcttttatg  aattttaga  1020
tgcctacaa  gtaaatttc  cattggaga  aatattggt  ggacctcgc  catcttcac  1080
tagccttcg  atttgtgaa  gattcagcc  ccttccttc  tcaccccat  cttctcacc  1140
aaattttgt  gtcattgag  gcacttgga  aactcaagt  gatatttat  gctgatcaa  1200
ctatatgtg  cacagaact  tgctgccta  agtgatctt  gctccttaa  ggtcctttt  1260
gccccttgg  tagttaaca  ctgagtaat  ctaatctct  ctgtgtttt  cttgcctta  1320
ccacaaatt  tggtgcttt  tgtatattt  atgtataaa  cacaaagtt  aattctgac  1380
atttttaag  caaaagtct  ttaaacttt  ttattgtaa  gaatattta  tatgcgaat  1440
tctattatt  tatggtatt  attgcaaaa  actgttgaa  tgtactcat  tttgaatat  1500
acaaaatat  aatacttaa  ggaaaataa  gtgacacga  gaaagtaca  atgttaact  1560
taatgcaga  aatatatta  ttaatgaaa  aaaaaaaaa  aaaa  1604



<210> 4658
<211> 139
<212> PRT
<213> Homo sapiens
<308> O43609
<400> 4658

Cys Glu Gln Cys Gly Lys Cys Lys Cys Gly Glu Cys Thr Ala Pro Arg 
  1               5                  10                  15
Thr Leu Pro Ser Cys Leu Ala Cys Asn Arg Gln Cys Leu Cys Ser Ala 
             20                  25                  30
Glu Ser Met Val Glu Tyr Gly Thr Cys Met Cys Leu Val Lys Gly Ile 
         35                  40                  45
Phe Tyr His Cys Ser Asn Asp Asp Glu Gly Asp Ser Tyr Ser Asp Asn 
     50                  55                  60
Pro Cys Ser Cys Ser Gln Ser His Cys Cys Ser Arg Tyr Leu Cys Met 
 65                  70                  75                  80
Gly Ala Met Ser Leu Phe Leu Pro Cys Leu Leu Cys Tyr Pro Pro Ala 
                 85                  90                  95
Lys Gly Cys Leu Lys Leu Cys Arg Arg Cys Tyr Asp Trp Ile His Arg 
             100                105                110
Pro Gly Cys Arg Cys Lys Asn Ser Asn Thr Val Tyr Cys Lys Leu Glu 
         115                120                125
Ser Cys Pro Ser Arg Gly Gln Gly Lys Pro Ser 
     130                135



<210> 4659
<211> 657
<212> DNA
<213> Rattus norvegicus
<308> AA800597
<400> 4659

atattccaa  ggtctttta  gaggataaa  agacaccaa  aatatcaag  tgtaacatt  60
cctttcaaa  gatctgggt  aacagagaa  acacatcca  ataacattt  tgtggatta  120
tattattaa  tataattat  cattcatgc  gtagtggta  caacgttca  atttgtctc  180
gtgactcat  acaaaggca  aatcaagta  gatgcatgt  taccataaa  aattaacat  240
caattttaa  cagatgaag  aaaggacca  tttgaagta  taaacagaa  tacctgtgt  300
agggtcaac  caatcattt  cactcctaa  catctgtac  aacactctg  attaacact  360
tccagaggt  accacgggt  agtgtctgt  tgatcaaca  ccactttaa  ttgtaacat  420
tgaacattt  tgtggagag  cgaagaact  actcagtga  ttcttaaaa  cccctcttt  480
tacttcagt  aatcctgtg  gaactaaaa  gcctttccc  tctgtatga  cattcagta  540
ttaagcagt  ttacattat  gacacattt  aggattatt  aaaaattga  gatagccat  600
cagtcacag  gcttaacat  aaggaaaca  taagttana  gccaggtga  ttgtttc  657



<210> 4660
<211> 657
<212> DNA
<213> Rattus norvegicus
<308> AA800597
<400> 4660

atattccaa  ggtctttta  gaggataaa  agacaccaa  aatatcaag  tgtaacatt  60
cctttcaaa  gatctgggt  aacagagaa  acacatcca  ataacattt  tgtggatta  120
tattattaa  tataattat  cattcatgc  gtagtggta  caacgttca  atttgtctc  180
gtgactcat  acaaaggca  aatcaagta  gatgcatgt  taccataaa  aattaacat  240
caattttaa  cagatgaag  aaaggacca  tttgaagta  taaacagaa  tacctgtgt  300
agggtcaac  caatcattt  cactcctaa  catctgtac  aacactctg  attaacact  360
tccagaggt  accacgggt  agtgtctgt  tgatcaaca  ccactttaa  ttgtaacat  420
tgaacattt  tgtggagag  cgaagaact  actcagtga  ttcttaaaa  cccctcttt  480
tacttcagt  aatcctgtg  gaactaaaa  gcctttccc  tctgtatga  cattcagta  540
ttaagcagt  ttacattat  gacacattt  aggattatt  aaaaattga  gatagccat  600
cagtcacag  gcttaacat  aaggaaaca  taagttana  gccaggtga  ttgtttc  657



<210> 4661
<211> 652
<212> DNA
<213> Rattus norvegicus
<308> AA800622
<400> 4661

agacagtaa  gcatgtatt  atatataca  atatataca  aatgtataa  tgaaatcct  60
atataagca  aggagttct  ttgacagaa  taaattata  gcaatacaa  aaaaatgaa  120
cttaattta  catagtggt  tgttttaaa  aactaaaac  gatttatac  tcaacaaat  180
ttggtcatt  gaacacaaa  tattctgat  gacacgtac  tttttatac  gcaattcaa  240
acaccctga  tttcacttc  caattgatg  ttaaatgct  atcatacta  ggaaataaa  300
atgtttaaa  tgaagagcc  ggcatcttg  cgtttagtt  actgaaatt  ctttgaaca  360
ttcagttag  ttatgtcaa  ggacctgta  ctactttga  ttgctctag  gactctgga  420
agctaacga  ttgctccaa  gcagatatc  aacgagaag  tgaaatcag  acgcgcaat  480
ctctgccca  gagccatca  ctcactcta  agcttctgt  tcatcacct  gaatttgca  540
gcaggcatt  aagatactt  agctgtcac  atacttttt  ttcccaagt  tgacaagcc  600
cctctgatt  agccacatg  aaacgctag  tacttggat  catgttcta  at  652



<210> 4662
<211> 3233
<212> DNA
<213> Homo sapiens
<308> AK056690
<400> 4662

tttttttcg  ccccgccca  cggccggat  gcatctcag  tggttggct  tggttagag  60
tcccgtcag  ctttcgttc  gccctagga  ttggtagcc  cgaagtgtg  gctctctcc  120
gtaccagac  catttcagt  ccagccttt  ggaagtcgt  tgaatacct  ggtctctta  180
ccacaggga  agaatggcg  cctgacgga  ccgcggcgc  ggcgaagtc  ctgaggcgc  240
agctggaac  cccagacca  ctcaaacgg  agccaaaac  cgaagcttg  aagaattag  300
aggaaatgg  ggatgaggc  ttgtttttg  ttctccata  cgagatggt  tctggagtg  360
acaagtccg  ggagcaggg  gaggtggaa  acggacgat  tattactaa  ctggaaaac  420
tggggtttc  agtgggaca  ggattgata  aaaggttta  aaaagatac  gcaaggttc  480
aggatgagt  agatatcat  aagttcatt  gtaaagatt  ttggactac  gtattcaag  540
aacaaatcg  caatctaag  acaaatcat  agtatttag  atttacgtg  ggcttaatc  600
gaggtggct  atcaaactt  ggaataaaa  gtattgtaa  agctgaagt  tcttcaatg  660
ctgcttgca  atttcaggt  atgatacag  agctgtaga  catactgaa  tgcaaggct  720
caacagtgt  aagagataa  ttattcatg  aaaagtatt  caagtagtg  tgatttaat  780
acattgttc  atgtttgta  aggagtaag  atgtatttt  atcaattta  cacagatca  840
aggagatga  gggacattc  gccatgaca  acacttaac  aaaactatt  aaaatgaaa  900
ccggatttc  aataaccag  caccaagat  cagggccct  attttaaac  tttttattt  960
gttagagtg  tatgtattt  gccatagat  gagaaacaa  gctcagggt  tgttgaatt  1020
gcatgagag  aaattatgt  ccaacagaa  tatttgtga  aagaatgaa  aaattttga  1080
aaagtatga  tttgtttta  tttaaaaag  aaacatact  aattttttt  attttattg  1140
ttataattt  ttaagaatg  ttacacctg  ataaggatt  catatatac  ttgtatgtg  1200
gtatatata  atacatata  gactgccta  attgtttat  aatttaatt  ttctttaat  1260
ggtttcatt  cttcagagc  ccattaatg  aatcaaaat  aaatataga  tagtttaaa  1320
gtgaattca  tgactctag  gccaaagaa  attaggtat  tttggaaag  atttttgta  1380
ttattcctg  tacagtttt  actttcaac  tctctcccc  tgcatggaa  tcctggtaa  1440
ggatctaac  tctttattc  cttctttcc  cttccagct  agcagagtt  gataattga  1500
ttagtcatt  tgacattct  tggaccata  catcttagt  gtttggggt  agtgctcat  1560
tgataaatc  ttcttacca  ctcttctac  tactttctc  tacttaaat  atctggcat  1620
agcagttat  tccagcttt  gttagaatc  tgcatgttg  ttactaaaa  tatactttg  1680
ttcccattt  tttattacc  ttttgcatg  atttgtgtg  cagggaact  tgcagcagg  1740
ggtgactga  acaccaaac  agatgtttc  ctgggtact  tgccataga  atggcagat  1800
aagaagatt  actatacca  acattatat  aaaaacaca  aataaaaac  ataaaaatg  1860
actttagga  attaaagaa  actcaagtt  gaagcatac  attttcctt  catggaagg  1920
tacagtatt  caaagataa  ttgtttaac  tgatttatt  aattctagt  atgtgccct  1980
taatgatgt  tcagtcagt  acagacctc  tatatggca  tggttccat  agattacaa  2040
actgtattt  tactgtacc  tctttatgt  tagatatgc  agtacttac  attgtgtta  2100
agtgtccta  agtattcac  acaataata  gctgtacag  tttgtagcc  aggagcaat  2160
ggccatagc  taggtgtat  gtagatcat  ccatctagg  ttgtgtaag  acactctgt  2220
attgtacaa  tttaaaatc  cctaatgat  atgcatttc  cagaatgta  cccctttgc  2280
aagcaatgc  tgactgcaa  cctaattct  acatgtttt  gggaaaaaa  tttaatttt  2340
aaaaaattt  ggaaagttc  tactaaata  acatgtata  agtttatta  aagtcataa  2400
gacccagga  tagctaatg  cacagaagt  gatcaaaat  gaacacaat  gagaacttc  2460
aaataaaac  ggtgtgaga  ttgtgtgtg  gaaaaagct  ggttcaaat  agttggttt  2520
ttagacatt  atatgccta  ccatcagcc  tttcgttct  ccttccttg  tgacaaagc  2580
ccatttttt  tttcttttt  tttggccta  aactctgta  ggctgcctt  tgctataga  2640
tagggtgct  ccctagcct  gagagggtg  gtgttgatt  gattctgtg  caatcatgg  2700
aattggctt  cttgatcat  tgatggaat  taggctaac  agacaaagg  agtctgaag  2760
ctttgaata  gaaattttc  gttgctctt  acaattgat  caagttagg  atttgccag  2820
atccctctt  tgcttctca  tgaagatat  tgatatgga  gtttgaagc  aatctgcaa  2880
agccttctg  tggccatga  aggacaagt  tggagatga  agctatcac  ctgagaata  2940
tgggatgta  atagaaagc  cctgaattg  gcttctgaa  taaccaatc  aggaactgc  3000
ttacctttg  actttttgt  atgtgagat  ttctttata  tgttccatt  gctttgggt  3060
tatgtatat  gttacttgt  gccaaaaag  aacctctct  agtagaaac  aagggagag  3120
taggttatt  aaaaattag  atgggacaa  tgaatatgc  tttttctgc  ggagtaggt  3180
gggagaaac  taaaggttc  cttgtaaaa  aataaagta  taaagaaaa  gtg  3233



<210> 4663
<211> 642
<212> DNA
<213> Rattus norvegicus
<308> AA800637
<400> 4663

gaggagagc  tttctactt  attacaaag  gaagaagcc  ttatgtggt  agaaaatac  60
agattgatc  tttttctct  cctatgaaa  gctgctgtt  acacagcca  agtgaattg  120
ctcagttca  gtcttgaag  cccatcaca  tcacttggg  atggatgtc  ttggctgct  180
aaaatctgg  cctttagtg  acagggcga  aaagtcccc  gaccagcag  tccagaatg  240
cccattttc  tatattgca  ccatgcaca  ctcctaaaa  tgaggtaca  cagggcaaa  300
attttccaa  atagatgtc  tatatataa  atatacaca  tcgtacata  ataccttta  360
tcatgtgat  tccaaaatt  aaaaaaaat  tacacattt  ttacaaaat  gtaacaaag  420
ctggacagt  ttttgctca  tctggaaag  tgaagctca  taacaacac  gccctggag  480
caccagaga  tgtggtaat  tctctacag  catattctt  cagtaagcc  ggagaaact  540
cctttcaga  acacaaggg  aagtaaaaa  aaagaagca  accttgctc  tctttccaa  600
tgaaatacg  gaaggatct  cacatcaaa  cgcacaaac  tc  642



<210> 4664
<211> 455
<212> PRT
<213> Rattus norvegicus
<308> BAB27481
<400> 4664

Met Arg Gly Met Ser Asn Asn Thr Pro Gln Leu Asn Arg Ser Leu Ser 
  1               5                  10                  15
Gln Gly Thr Gln Leu Pro Ser His Val Thr Pro Thr Thr Gly Val Pro 
             20                  25                  30
Thr Met Ser Leu His Thr Pro Pro Ser Pro Ser Arg Gly Ile Leu Pro 
         35                  40                  45
Met Asn Pro Arg Asn Met Met Asn His Ser Gln Val Gly Gln Gly Ile 
     50                  55                  60
Gly Ile Pro Ser Arg Thr Asn Ser Met Ser Ser Ser Gly Leu Gly Ser 
 65                  70                  75                  80
Pro Asn Arg Ser Ser Pro Ser Ile Ile Cys Met Pro Lys Gln Gln Pro 
                 85                  90                  95
Ser Arg Gln Pro Phe Thr Val Asn Ser Met Ser Gly Phe Gly Met Asn 
             100                105                110
Arg Asn Gln Ala Phe Gly Met Asn Asn Ser Leu Ser Ser Asn Ile Phe 
         115                120                125
Asn Gly Thr Asp Gly Ser Glu Asn Val Thr Gly Leu Asp Leu Ser Asp 
     130                135                140
Phe Pro Ala Leu Ala Asp Arg Asn Arg Arg Glu Gly Ser Gly Asn Pro 
 145                150                155                160
Thr Pro Leu Ile Asn Pro Leu Ala Gly Arg Ala Pro Tyr Val Gly Met 
                 165                170                175
Val Thr Lys Pro Ala Asn Glu Gln Ser Gln Asp Phe Ser Ile His Asn 
             180                185                190
Glu Asp Phe Pro Ala Leu Pro Gly Ser Ser Tyr Lys Asp Pro Thr Ser 
         195                200                205
Ser Asn Asp Asp Ser Lys Ser Asn Leu Ser Thr Ser Gly Lys Thr Thr 
     210                215                220
Ser Ser Thr Asp Gly Pro Lys Phe Pro Gly Asp Lys Ser Ser Thr Thr 
 225                230                235                240
Gln Asn Asn Asn Gln Gln Lys Lys Gly Ile Gln Val Leu Pro Asp Gly 
                 245                250                255
Arg Val Thr Asn Ile Pro Gln Gly Met Val Thr Asp Gln Phe Gly Met 
             260                265                270
Ile Gly Leu Leu Thr Phe Ile Arg Ala Ala Glu Thr Asp Pro Gly Met 
         275                280                285
Val His Leu Ala Leu Gly Ser Asp Leu Thr Thr Leu Gly Leu Asn Leu 
     290                295                300
Asn Ser Pro Glu Asn Leu Tyr Pro Lys Phe Ala Ser Pro Trp Ala Ser 
 305                310                315                320
Ser Pro Cys Arg Pro Gln Asp Ile Asp Phe His Val Pro Ser Glu Tyr 
                 325                330                335
Leu Thr Asn Ile His Ile Arg Asp Lys Leu Ala Ala Ile Lys Leu Gly 
             340                345                350
Arg Tyr Gly Glu Asp Leu Leu Phe Tyr Leu Tyr Tyr Met Asn Gly Gly 
         355                360                365
Asp Val Leu Gln Leu Leu Ala Ala Val Glu Leu Phe Asn Arg Asp Trp 
     370                375                380
Arg Tyr His Lys Glu Glu Arg Val Trp Ile Thr Arg Ala Pro Gly Met 
 385                390                395                400
Glu Pro Thr Met Lys Thr Asn Thr Tyr Glu Arg Gly Thr Tyr Tyr Phe 
                 405                410                415
Phe Asp Cys Leu Asn Trp Arg Lys Val Ala Lys Glu Phe His Leu Glu 
             420                425                430
Tyr Asp Lys Leu Glu Glu Arg Pro His Leu Pro Ser Thr Phe Asn Tyr 
         435                440                445
Asn Pro Ala Gln Gln Ala Phe 
     450                455



<210> 4665
<211> 625
<212> DNA
<213> Homo sapiens
<308> AF147398
<400> 4665

ttttttttt  gaggagagc  tttctactt  attacaaag  gaagaagcc  ttatgtggt  60
agaaaatac  agattgatc  ttttttctc  tcctatgaa  cgctgctgt  caaacagcc  120
gagtgaatt  tctcagttc  cttctttta  gtcccatca  attcacttg  gtatggatg  180
ccttggctg  tgaaaatct  gccctttta  tgcacaggg  gacaaagtc  cctgaccag  240
agttccaga  tgtcccatt  tcatatatt  catccatgc  cacctccta  aaatgaggt  300
cagcagggc  aacattttc  aaaatagat  tcatatata  aatatatac  cattcgtac  360
tacatacct  tattcatgt  atgtccaaa  atttaaaaa  aatgtacac  tttattaca  420
aatcgtaac  aagactgga  agtgttttg  tcattctgg  aagatgaag  tcagtaata  480
cacaaccct  gaaaaccat  cagagattg  ggcaatatc  ttcttctaa  cagtcagat  540
ttcttgcat  aagcttggc  aaactgcct  tcaaaaaca  aaggggaag  aaaatgaag  600
aagcagacc  cttgctcat  tttcc  625



<210> 4666
<211> 583
<212> DNA
<213> Rattus norvegicus
<308> AA800639
<400> 4666

agaagcaaa  tacaaatgt  ttatttatt  tttaggaaa  tcccagact  ttccacagg  60
aaatagaca  gcattcatc  cattatttt  attgctaaa  cagaacaat  atttatggt  120
acattcaat  ataactgtc  ctgaggatg  ggagttaaa  gttaaaatt  attaaacta  180
atggtaaag  cacaatgct  aaataaaca  tcattccta  catttcatg  ctatagatt  240
tatcctata  gaatgaaaa  taaaagtaa  tttgttaac  taaacaaaa  catacaaaa  300
aaaaagtta  gaaaataca  ggaaaggca  aggtcactt  ggaaaattt  taaacaaca  360
aattagaaa  aaatatatc  gagcagaca  gtttgtgtt  ttaacaata  atacaactg  420
aaaagtatc  taggagtga  gactaaaat  acctctgta  taagaaccc  acatgaact  480
aaacatagg  tacaatatc  ccacatagt  tatgttttg  cataaaggg  tatattctg  540
ccactgagt  tatacagac  ataaaatta  attccaaaa  tac  583



<210> 4667
<211> 539
<212> DNA
<213> Rattus norvegicus
<308> AA800651
<400> 4667

acaaacata  actttatta  atgctgctc  atccccagt  aagatcttt  attataaaa  60
ggttttcca  acaactgca  ggcaagagg  tggaatggt  ctgataaca  caggtgtga  120
aaatacccg  ccaggtaaa  acatacaag  cttctacgc  gtcaattca  agtttgccc  180
ctgcatttc  cttacacaa  gccaggcag  gatagctag  agtccgcat  acactgtgg  240
acccagggc  tccttcacc  tgcaggcag  cctgggacg  gcaggttga  gactgggaa  300
gccctgcct  cagccttgg  ggaatgaag  aggtgagct  gggtccacc  gccggtgct  360
ctctgcgca  gctctgggt  ctgctgctg  aggggattt  ggaacagtc  acatttggt  420
tacttcccc  cagctttta  tactttgtg  ttcggaagc  tggaaacgc  agatgttgc  480
aaacccaga  tatggcagt  tctttaatg  ggctgggcc  ttatctcnc  aaccgcctc  539



<210> 4669
<211> 486
<212> PRT
<213> Homo sapiens
<308> Q15172
<400> 4669

Met Ser Ser Ser Ser Pro Pro Ala Gly Ala Ala Ser Ala Ala Ile Ser 
  1               5                  10                  15
Ala Ser Glu Lys Val Asp Gly Phe Thr Arg Lys Ser Val Arg Lys Ala 
             20                  25                  30
Gln Arg Gln Lys Arg Ser Gln Gly Ser Ser Gln Phe Arg Ser Gln Gly 
         35                  40                  45
Ser Gln Ala Glu Leu His Pro Leu Pro Gln Leu Lys Asp Ala Thr Ser 
     50                  55                  60
Asn Glu Gln Gln Glu Leu Phe Cys Gln Lys Leu Gln Gln Cys Cys Ile 
 65                  70                  75                  80
Leu Phe Asp Phe Met Asp Ser Val Ser Asp Leu Lys Ser Lys Glu Ile 
                 85                  90                  95
Lys Arg Ala Thr Leu Asn Glu Leu Val Glu Tyr Val Ser Thr Asn Arg 
             100                105                110
Gly Val Ile Val Glu Ser Ala Tyr Ser Asp Ile Val Lys Met Ile Ser 
         115                120                125
Ala Asn Ile Phe Arg Thr Leu Pro Pro Ser Asp Asn Pro Asp Phe Asp 
     130                135                140
Pro Glu Glu Asp Glu Pro Thr Leu Glu Ala Ser Trp Pro His Ile Gln 
 145                150                155                160
Leu Val Tyr Glu Phe Phe Leu Arg Phe Leu Glu Ser Pro Asp Phe Gln 
                 165                170                175
Pro Ser Ile Ala Lys Arg Tyr Ile Asp Gln Lys Phe Val Gln Gln Leu 
             180                185                190
Leu Glu Leu Phe Asp Ser Glu Asp Pro Arg Glu Arg Asp Phe Leu Lys 
         195                200                205
Thr Val Leu His Arg Ile Tyr Gly Lys Phe Leu Gly Leu Arg Ala Phe 
     210                215                220
Ile Arg Lys Gln Ile Asn Asn Ile Phe Leu Arg Phe Ile Tyr Glu Thr 
 225                230                235                240
Glu His Phe Asn Gly Val Ala Glu Leu Leu Glu Ile Leu Gly Ser Ile 
                 245                250                255
Ile Asn Gly Phe Ala Leu Pro Leu Lys Ala Glu His Lys Gln Phe Leu 
             260                265                270
Met Lys Val Leu Ile Pro Met His Thr Ala Lys Gly Leu Ala Leu Phe 
         275                280                285
His Ala Gln Leu Ala Tyr Cys Val Val Gln Phe Leu Glu Lys Asp Thr 
     290                295                300
Thr Leu Thr Glu Pro Val Ile Arg Gly Leu Leu Lys Phe Trp Pro Lys 
 305                310                315                320
Thr Cys Ser Gln Lys Glu Val Met Phe Leu Gly Glu Ile Glu Glu Ile 
                 325                330                335
Leu Asp Val Ile Glu Pro Thr Gln Phe Lys Lys Ile Glu Glu Pro Leu 
             340                345                350
Phe Lys Gln Ile Ser Lys Cys Val Ser Ser Ser His Phe Gln Val Ala 
         355                360                365
Glu Arg Ala Leu Tyr Phe Trp Asn Asn Glu Tyr Ile Leu Ser Leu Ile 
     370                375                380
Glu Glu Asn Ile Asp Lys Ile Leu Pro Ile Met Phe Ala Ser Leu Tyr 
 385                390                395                400
Lys Ile Ser Lys Glu His Trp Asn Pro Thr Ile Val Ala Leu Val Tyr 
                 405                410                415
Asn Val Leu Lys Thr Leu Met Glu Met Asn Gly Lys Leu Phe Asp Asp 
             420                425                430
Leu Thr Ser Ser Tyr Lys Ala Glu Arg Gln Arg Glu Lys Lys Lys Glu 
         435                440                445
Leu Glu Arg Glu Glu Leu Trp Lys Lys Leu Glu Glu Leu Lys Leu Lys 
     450                455                460
Lys Ala Leu Glu Lys Gln Asn Ser Ala Tyr Asn Met His Ser Ile Leu 
 465                470                475                480
Ser Asn Thr Ser Ala Glu 
                 485



<210> 4670
<211> 362
<212> DNA
<213> Rattus norvegicus
<308> AA800663
<400> 4670

caagggaga  tgttaaata  ttcatgcta  gtagacctt  ttattaaga  cccctcccc  60
gtagtaact  cctccagtt  atacattca  gagtgcagg  tacatacat  aatatccac  120
cacacatcc  cacacactg  ctcaagggc  ggggaagac  aaagttatg  ccacacata  180
taggcctct  gtggactca  gcaattgct  aacaagaga  caaatggct  aattctcca  240
cgtctccct  cagagacca  gaatcctaa  acacaaacc  aaactttta  cagcaagag  300
catctttct  aggatgaag  taccttata  gggaaagga  tgggataaa  caccagaaa  360
tt  362



<210> 4671
<211> 1087
<212> PRT
<213> Rattus norvegicus
<308> NP_075532
<400> 4671

Met Ala Asp His Val Gln Ser Leu Ala Gln Leu Glu Asn Leu Cys Lys 
  1               5                  10                  15
Gln Leu Tyr Glu Thr Thr Asp Thr Thr Thr Arg Leu Gln Ala Glu Lys 
             20                  25                  30
Ala Leu Val Glu Phe Thr Asn Ser Pro Asp Cys Leu Ser Lys Cys Gln 
         35                  40                  45
Leu Leu Leu Glu Arg Gly Ser Ser Ser Tyr Ser Gln Leu Leu Ala Ala 
     50                  55                  60
Thr Cys Leu Thr Lys Leu Val Ser Arg Thr Asn Asn Pro Leu Pro Leu 
 65                  70                  75                  80
Glu Gln Arg Ile Asp Ile Arg Asn Tyr Val Leu Asn Tyr Leu Ala Thr 
                 85                  90                  95
Arg Pro Lys Leu Ala Thr Phe Val Thr Gln Ala Leu Ile Gln Leu Tyr 
             100                105                110
Ala Arg Ile Thr Lys Leu Gly Trp Phe Asp Cys Gln Lys Asp Asp Tyr 
         115                120                125
Val Phe Arg Asn Ala Ile Thr Asp Val Thr Arg Phe Leu Gln Asp Ser 
     130                135                140
Val Glu Tyr Cys Ile Ile Gly Val Thr Ile Leu Ser Gln Leu Thr Asn 
 145                150                155                160
Glu Ile Asn Gln Ala Asp Thr Thr His Pro Leu Thr Lys His Arg Lys 
                 165                170                175
Ile Ala Ser Ser Phe Arg Asp Ser Ser Leu Phe Asp Ile Phe Thr Leu 
             180                185                190
Ser Cys Asn Leu Leu Lys Gln Ala Ser Gly Lys Asn Leu Asn Leu Asn 
         195                200                205
Asp Glu Ser Gln His Gly Leu Leu Met Gln Leu Leu Lys Leu Thr His 
     210                215                220
Asn Cys Leu Asn Phe Asp Phe Ile Gly Thr Ser Thr Asp Glu Ser Ser 
 225                230                235                240
Asp Asp Leu Cys Thr Val Gln Ile Pro Thr Ser Trp Arg Ser Ala Phe 
                 245                250                255
Leu Asp Ser Ser Thr Leu Gln Leu Phe Phe Asp Leu Tyr His Ser Ile 
             260                265                270
Pro Pro Ser Phe Ser Pro Leu Val Leu Ser Cys Leu Val Gln Ile Ala 
         275                280                285
Ser Val Arg Arg Ser Leu Phe Asn Asn Ala Glu Arg Ala Lys Phe Leu 
     290                295                300
Ser His Leu Val Asp Gly Val Lys Arg Ile Leu Glu Asn Pro Gln Ser 
 305                310                315                320
Leu Ser Asp Pro Asn Asn Tyr His Glu Phe Cys Arg Leu Leu Ala Arg 
                 325                330                335
Leu Lys Ser Asn Tyr Gln Leu Gly Glu Leu Val Lys Val Glu Asn Tyr 
             340                345                350
Pro Asp Val Ile Arg Leu Ile Ala Asn Phe Thr Val Thr Ser Leu Gln 
         355                360                365
His Trp Glu Phe Ala Pro Asn Ser Val His Tyr Leu Leu Ser Leu Trp 
     370                375                380
Gln Arg Leu Ala Ala Ser Val Pro Tyr Val Lys Ala Thr Glu Pro His 
 385                390                395                400
Met Leu Glu Thr Tyr Thr Pro Glu Val Thr Lys Ala Tyr Ile Thr Ser 
                 405                410                415
Arg Leu Glu Ser Val His Ile Ile Leu Arg Asp Gly Leu Glu Asp Pro 
             420                425                430
Leu Glu Asp Thr Gly Leu Val Gln Gln Gln Leu Asp Gln Leu Ser Thr 
         435                440                445
Ile Gly Arg Cys Glu Tyr Glu Lys Thr Cys Ala Leu Leu Val Gln Leu 
     450                455                460
Phe Asp Gln Ser Ala Gln Ser Tyr Gln Glu Leu Leu Gln Ser Ala Ser 
 465                470                475                480
Ala Ser Pro Met Asp Ile Ala Val Gln Glu Gly Arg Leu Thr Trp Leu 
                 485                490                495
Val Tyr Ile Ile Gly Ala Val Ile Gly Gly Arg Val Ser Phe Ala Ser 
             500                505                510
Thr Asp Glu Gln Asp Ala Met Asp Gly Glu Leu Val Cys Arg Val Leu 
         515                520                525
Gln Leu Met Asn Leu Thr Asp Ser Arg Leu Ala Gln Ala Gly Asn Glu 
     530                535                540
Lys Leu Glu Leu Ala Met Leu Ser Phe Phe Glu Gln Phe Arg Lys Ile 
 545                550                555                560
Tyr Ile Gly Asp Gln Val Gln Lys Ser Ser Lys Leu Tyr Arg Arg Leu 
                 565                570                575
Ser Glu Val Leu Gly Leu Asn Asp Glu Thr Met Val Leu Ser Val Phe 
             580                585                590
Ile Gly Lys Val Ile Thr Asn Leu Lys Tyr Trp Gly Arg Cys Glu Pro 
         595                600                605
Ile Thr Ser Lys Thr Leu Gln Leu Leu Asn Asp Leu Ser Ile Gly Tyr 
     610                615                620
Ser Ser Val Arg Lys Leu Val Lys Leu Ser Ala Val Gln Phe Met Leu 
 625                630                635                640
Asn Asn His Thr Ser Glu His Phe Ser Phe Leu Gly Ile Asn Asn Gln 
                 645                650                655
Ser Asn Leu Thr Asp Met Arg Cys Arg Thr Thr Phe Tyr Thr Ala Leu 
             660                665                670
Gly Arg Leu Leu Met Val Asp Leu Gly Glu Asp Glu Asp Gln Tyr Glu 
         675                680                685
Gln Phe Met Leu Pro Leu Thr Ala Ala Phe Glu Ala Val Ala Gln Met 
     690                695                700
Phe Ser Thr Asn Ser Phe Asn Glu Gln Glu Ala Lys Arg Thr Leu Val 
 705                710                715                720
Gly Leu Val Arg Asp Leu Arg Gly Ile Ala Phe Ala Phe Asn Ala Lys 
                 725                730                735
Thr Ser Phe Met Met Leu Phe Glu Trp Ile Tyr Pro Ser Tyr Met Pro 
             740                745                750
Ile Leu Gln Arg Ala Ile Glu Leu Trp Tyr His Asp Pro Ala Cys Thr 
         755                760                765
Thr Pro Val Leu Lys Leu Met Ala Glu Leu Val His Asn Arg Ser Gln 
     770                775                780
Arg Leu Gln Phe Asp Val Ser Ser Pro Asn Gly Ile Leu Leu Phe Arg 
 785                790                795                800
Glu Thr Ser Lys Met Ile Thr Met Tyr Gly Asn Arg Ile Leu Thr Leu 
                 805                810                815
Gly Glu Val Pro Lys Asp Gln Val Tyr Ala Leu Lys Leu Lys Gly Ile 
             820                825                830
Ser Ile Cys Phe Ser Met Leu Lys Ala Ala Leu Ser Gly Ser Tyr Val 
         835                840                845
Asn Phe Gly Val Phe Arg Leu Tyr Gly Asp Asp Ala Leu Glu Asn Ala 
     850                855                860
Leu Gln Thr Phe Ile Lys Leu Leu Leu Ser Ile Pro His Ser Asp Leu 
 865                870                875                880
Leu Asp Tyr Pro Lys Leu Ser Gln Ser Tyr Tyr Ser Leu Leu Glu Val 
                 885                890                895
Leu Thr Gln Asp His Met Asn Phe Ile Ala Ser Leu Glu Pro His Val 
             900                905                910
Ile Met Tyr Ile Leu Ser Ser Ile Ser Glu Gly Leu Thr Ala Leu Asp 
         915                920                925
Thr Met Val Cys Thr Gly Cys Cys Ser Cys Leu Asp His Ile Val Thr 
     930                935                940
Tyr Leu Phe Lys Gln Leu Ser Arg Ser Thr Lys Lys Arg Thr Thr Pro 
 945                950                955                960
Leu Asn Arg Glu Ser Asp Cys Phe Leu His Ile Met Gln Gln His Pro 
                 965                970                975
Ala Met Ile Gln Gln Met Leu Ser Thr Val Leu Asn Ile Ile Ile Phe 
             980                985                990
Glu Asp Cys Arg Asn Gln Trp Ser Met Ser Arg Pro Leu Leu Gly Leu 
         995                1000                1005
Ile Leu Leu Asn Glu Lys Tyr Phe Ser Asp Leu Arg Asn Ser Ile Val 
     1010                1015                1020
Asn Ser Gln Pro Pro Glu Lys Gln Gln Ala Met His Leu Cys Phe Glu 
 1025                1030                1035                1040
Asn Leu Met Glu Gly Ile Glu Arg Asn Leu Leu Thr Lys Asn Arg Asp 
                 1045                1050                1055
Arg Phe Thr Gln Asn Leu Ser Ala Phe Arg Arg Glu Val Asn Asp Ser 
             1060                1065                1070
Met Lys Asn Ser Thr Tyr Gly Val Asn Ser Asn Asp Met Met Ser 
         1075                1080                1085



<210> 4672
<211> 4228
<212> DNA
<213> Homo sapiens
<308> AB018288
<400> 4672

gaatggagc  aaatggcgg  tcatgtgca  agcctggcc  aactagaga  tctgtgcaa  60
cagctgtat  aaaccacag  cacaaccac  cgactccag  cagagaaag  cttggttga  120
tttaccaac  gccctgatt  cctgagcaa  tgccagcta  tcctcgaaa  aggaagttc  180
tcttactcc  agttactgg  agctacatg  cttaccaag  ttgtatcac  cacaaacaa  240
cccctacca  tggaacagc  aatagatat  cggaactat  tgctcaact  ccttgccac  300
cggccgaag  tggctactt  cgtgacaca  gcacttatt  agttatatg  cagaatcac  360
aaactgggc  ggtttgact  tcagaagga  gactatgtc  tcagaaatg  aatcacaga  420
gtcacaagg  ttttacagg  tagtgttga  tactgcatc  ttggtgtca  aattttatc  480
cagctaacc  atgaaatta  tcaagcaga  accacccat  ctttaacca  gcacagaaa  540
atagcctct  cttttcgcg  ttcatcatt  tttgatatc  tcacacttt  ctgcaattt  600
ctaaaacag  cttcaggaa  gaatctaaa  ttgaatgat  aaagtcagc  tggcttgct  660
atgcaactg  tcaagctca  tcataactg  ctcaacttt  acttcatcg  cacttccac  720
gatgagtcc  cagacgacc  gtgtacagt  cagattccc  ccagctgga  atcagcctt  780
ttagattct  caaccttgc  gctgtccac  attgggcgt  gtgaatatg  gaagacgtg  840
gcactcctc  tgcagttgt  tgaccagtc  gcccagtcg  accaggagc  gctacagag  900
gccagcgca  gcccaatgg  cattgcagt  caggaggga  ggctgacat  gctggttta  960
attattgga  cagtgatcg  tggccgggt  tcttttgcc  gcactgatg  gcaagacgc  1020
atggatggt  agcttgtct  tcgggtgct  cagctgatg  acctaacag  ttctcgttt  1080
gcccaggcg  gtaatgaga  gctagagtt  gccatgctg  gcttttttg  acagtttcg  1140
aagatctac  ttggggacc  agtgcagaa  tcctctaag  tgtaccgcc  actctcaga  1200
gttctgggc  tgaatgatg  gaccatggt  ctaagcgtc  tcataggaa  aatcatcac  1260
aacttgaag  actggggcc  ttgtgaacc  atcacctcc  agacactac  gcttctcaa  1320
gacctgtcc  ttgggtaca  tagcgtaag  aagctagtg  agcttagtg  ggtacagtt  1380
atgctgaac  atcacacga  cgagcactt  tcatttttg  gtattaaca  tcagtccaa  1440
ctgacagac  tgcggtgtc  gactacctt  tacacagca  ttgggcgtc  cctcatggt  1500
gatttagga  aggatgaag  tcagtatga  cagttcatg  tgccactca  agcagcatt  1560
gaggctgtg  cccagatgt  tagcaccaa  agtttcaac  agcaggagg  aaagcgaac  1620
ctagttggc  tagtaagag  cctgagagg  atcgctttc  ctttcaatg  caagaccag  1680
ttcatgatg  tctttgaat  gatatatcc  tcctatatg  caattctcc  acgggcaat  1740
gagctctgg  accatgatc  agcctgtac  acacctgta  tcaagttga  ggctgaatt  1800
gttcataat  ggtcccagc  actccagtt  gatgtctct  cccccaatg  catcttact  1860
ttccgagaa  ccagcaaga  gataacaat  tatggcaat  gcatcctga  actaggaga  1920
gtcccaaag  atcaggtct  tgctctgaa  ctcaagggc  tctccatct  cttctccat  1980
ctgaaggct  ctctcagtg  gagttacgt  aatttcgga  tctttcgtc  ctatggaga  2040
gatgccctg  acaatgctc  gcagacctt  atcaagctg  tcctctcta  tcctcacag  2100
gatctcttg  attacccca  gctcagcca  tcttattat  cactactgg  agtcctgac  2160
caggaccat  tgaacttta  tgcaagcct  gaacctcac  tcatcatgt  tattctctc  2220
tccatttct  aaggactta  tgcacttga  accatggta  gcacaggct  ctgctcctg  2280
ctggaccac  ttgtgacat  cctcttcaa  cagctgtca  gtagcacca  gaagaggac  2340
acacccctg  accaggaga  cgaccgctt  ctgcacatc  tgcagcagc  tccagagat  2400
atccagcag  tgctgtcca  ggtgctgaa  atcatcatc  ttgaagact  taggaacca  2460
tggtctatg  cccgaccac  acttggctt  atattgctt  atgaaaagt  tttttctga  2520
ctaagaaac  gtattgtga  cagccagcc  ccggagaag  agcaggcca  gcacctgtg  2580
tttgagaac  tgatggaag  catcgagcg  aatcttctt  cgaaaaaca  agacaggtt  2640
acccagaac  tgtcagcat  ccgtcgaga  gtcaacgac  caatgaaga  ttccactta  2700
ggcgtgaat  gcaatgaca  gatgagctg  cacctcctt  gactctacc  gtacagagc  2760
gcgtccctt  ggtttggcc  agaggggcg  acaattgca  gggagaggg  ctggctgat  2820
ctggctctt  tctccaggg  tgtggggaa  atggcaaag  tcaactagc  gcttcccca  2880
ggaataggg  tgtgagtac  ctcactagg  ggcagggcg  tgctggttc  tgggggact  2940
ggtgggaag  gtggtggga  gagataaga  atacaaact  agactccag  ctctcctcc  3000
ggggccacc  aagtgggga  aacccctag  gtcctgcca  aacctgcct  gtataaaca  3060
gtacatttt  tcataacat  ttgaacaag  tttatattg  ctcaagttt  aaaacaaaa  3120
gtgtgactg  aaaattttt  cagagtcta  tgcaccaat  ctgatgtga  gggttgtgt  3180
tgcgagtga  gaaaatgtg  attctggtg  cctgaagct  tactggaca  ggatgtgtg  3240
gagtgcaga  atatattta  tgacacagt  gagaggcaa  aaaaaaaag  taaaattcc  3300
aatgtatat  ttttcgtat  gccctgtcc  cacccagaa  tgatcaatt  ctgttactg  3360
attaaccct  gttattagg  actctaagc  atgccagaa  accgtccct  cccttggac  3420
gtgtagatt  tgccctggg  ccctagccc  ttgcagtga  aaataactc  agctaaaag  3480
gtttggtgt  cttatctcc  ccctctttc  tactttgct  accctcatc  tcagacaga  3540
gcctcttgc  tttaaaagt  ggatttaac  acgtgttgt  gggttcttg  tctgtgtga  3600
ggcagagac  agagagaag  aagtgagcc  actgctctc  tgggagcaa  gtgggtgag  3660
ccaccagag  ccctgctgt  tgtggccaa  aaattttag  cttccccag  cctcgaggc  3720
gtgtgtgtg  atgtatgcg  gtggatatt  atatatgta  cctgcactc  tgaatgtat  3780
aactggagg  agttactac  gtggaaggg  tcttaataa  aaggtctac  tagcatgaa  3840
tatttaaca  tctcccatc  cttaaaaaa  atacatttt  ataaaatga  aaccataat  3900
aatgttttg  atattaaaa  aaataataa  ctacagagg  aaattaatg  agacagcta  3960
ttgccttgt  ctttttcca  aattgttgc  gctagttgt  cacatctct  gttcagctc  4020
tgcccacgg  acactcatc  attaggttt  atttttatt  ctttcctct  cccccagaa  4080
caagcctgt  aattttttt  ccttctcct  tggcgactg  gtgatgaat  ctttcttgc  4140
tgatcaggt  gcggataga  ttgtaaggg  gtttgctgc  tacagtgta  gcattgtga  4200
cgccaataa  cttcaatgg  ttctactg  4228



<210> 4673
<211> 1087
<212> PRT
<213> Homo sapiens
<308> Q9UIA9
<400> 4673

Met Ala Asp His Val Gln Ser Leu Ala Gln Leu Glu Asn Leu Cys Lys 
  1               5                  10                  15
Gln Leu Tyr Glu Thr Thr Asp Thr Thr Thr Arg Leu Gln Ala Glu Lys 
             20                  25                  30
Ala Leu Val Glu Phe Thr Asn Ser Pro Asp Cys Leu Ser Lys Cys Gln 
         35                  40                  45
Leu Leu Leu Glu Arg Gly Ser Ser Ser Tyr Ser Gln Leu Leu Ala Ala 
     50                  55                  60
Thr Cys Leu Thr Lys Leu Val Ser Arg Thr Asn Asn Pro Leu Pro Leu 
 65                  70                  75                  80
Glu Gln Arg Ile Asp Ile Arg Asn Tyr Val Leu Asn Tyr Leu Ala Thr 
                 85                  90                  95
Arg Pro Lys Leu Ala Thr Phe Val Thr Gln Ala Leu Ile Gln Leu Tyr 
             100                105                110
Ala Arg Ile Thr Lys Leu Gly Trp Phe Asp Cys Gln Lys Asp Asp Tyr 
         115                120                125
Val Phe Arg Asn Ala Ile Thr Asp Val Thr Arg Phe Leu Gln Asp Ser 
     130                135                140
Val Glu Tyr Cys Ile Ile Gly Val Thr Ile Leu Ser Gln Leu Thr Asn 
 145                150                155                160
Glu Ile Asn Gln Ala Asp Thr Thr His Pro Leu Thr Lys His Arg Lys 
                 165                170                175
Ile Ala Ser Ser Phe Arg Asp Ser Ser Leu Phe Asp Ile Phe Thr Leu 
             180                185                190
Ser Cys Asn Leu Leu Lys Gln Ala Ser Gly Lys Asn Leu Asn Leu Asn 
         195                200                205
Asp Glu Ser Gln His Gly Leu Leu Met Gln Leu Leu Lys Leu Thr His 
     210                215                220
Asn Cys Leu Asn Phe Asp Phe Ile Gly Thr Ser Thr Asp Glu Ser Ser 
 225                230                235                240
Asp Asp Leu Cys Thr Val Gln Ile Pro Thr Ser Trp Arg Ser Ala Phe 
                 245                250                255
Leu Asp Ser Ser Thr Leu Gln Leu Phe Phe Asp Leu Tyr His Ser Ile 
             260                265                270
Pro Pro Ser Phe Ser Pro Leu Val Leu Ser Cys Leu Val Gln Ile Ala 
         275                280                285
Ser Val Arg Arg Ser Leu Phe Asn Asn Ala Glu Arg Ala Lys Phe Leu 
     290                295                300
Ser His Leu Val Asp Gly Val Lys Arg Ile Leu Glu Asn Pro Gln Ser 
 305                310                315                320
Leu Ser Asp Pro Asn Asn Tyr His Glu Phe Cys Arg Leu Leu Ala Arg 
                 325                330                335
Leu Lys Ser Asn Tyr Gln Leu Gly Glu Leu Val Lys Val Glu Asn Tyr 
             340                345                350
Pro Glu Val Ile Arg Leu Ile Ala Asn Phe Thr Val Thr Ser Leu Gln 
         355                360                365
His Trp Glu Phe Ala Pro Asn Ser Val His Tyr Leu Leu Ser Leu Trp 
     370                375                380
Gln Arg Leu Ala Ala Ser Val Pro Tyr Val Lys Ala Thr Glu Pro His 
 385                390                395                400
Met Leu Glu Thr Tyr Thr Pro Glu Val Thr Lys Ala Tyr Ile Thr Ser 
                 405                410                415
Arg Leu Glu Ser Val His Ile Ile Leu Arg Asp Gly Leu Glu Asp Pro 
             420                425                430
Leu Glu Asp Thr Gly Leu Val Gln Gln Gln Leu Asp Gln Leu Ser Thr 
         435                440                445
Ile Gly Arg Cys Glu Tyr Glu Lys Thr Cys Ala Leu Leu Val Gln Leu 
     450                455                460
Phe Asp Gln Ser Ala Gln Ser Tyr Gln Glu Leu Leu Gln Ser Ala Ser 
 465                470                475                480
Ala Ser Pro Met Asp Ile Ala Val Gln Glu Gly Arg Leu Thr Trp Leu 
                 485                490                495
Val Tyr Ile Ile Gly Ala Val Ile Gly Gly Arg Val Ser Phe Ala Ser 
             500                505                510
Thr Asp Glu Gln Asp Ala Met Asp Gly Glu Leu Val Cys Arg Val Leu 
         515                520                525
Gln Leu Met Asn Leu Thr Asp Ser Arg Leu Ala Gln Ala Gly Asn Glu 
     530                535                540
Lys Leu Glu Leu Ala Met Leu Ser Phe Phe Glu Gln Phe Arg Lys Ile 
 545                550                555                560
Tyr Ile Gly Asp Gln Val Gln Lys Ser Ser Lys Leu Tyr Arg Arg Leu 
                 565                570                575
Ser Glu Val Leu Gly Leu Asn Asp Glu Thr Met Val Leu Ser Val Phe 
             580                585                590
Ile Gly Lys Ile Ile Thr Asn Leu Lys Tyr Trp Gly Arg Cys Glu Pro 
         595                600                605
Ile Thr Ser Lys Thr Leu Gln Leu Leu Asn Asp Leu Ser Ile Gly Tyr 
     610                615                620
Ser Ser Val Arg Lys Leu Val Lys Leu Ser Ala Val Gln Phe Met Leu 
 625                630                635                640
Asn Asn His Thr Ser Glu His Phe Ser Phe Leu Gly Ile Asn Asn Gln 
                 645                650                655
Ser Asn Leu Thr Asp Met Arg Cys Arg Thr Thr Phe Tyr Thr Ala Leu 
             660                665                670
Gly Arg Leu Leu Met Val Asp Leu Gly Glu Asp Glu Asp Gln Tyr Glu 
         675                680                685
Gln Phe Met Leu Pro Leu Thr Ala Ala Phe Glu Ala Val Ala Gln Met 
     690                695                700
Phe Ser Thr Asn Ser Phe Asn Glu Gln Glu Ala Lys Arg Thr Leu Val 
 705                710                715                720
Gly Leu Val Arg Asp Leu Arg Gly Ile Ala Phe Ala Phe Asn Ala Lys 
                 725                730                735
Thr Ser Phe Met Met Leu Phe Glu Trp Ile Tyr Pro Ser Tyr Met Pro 
             740                745                750
Ile Leu Gln Arg Ala Ile Glu Leu Trp Tyr His Asp Pro Ala Cys Thr 
         755                760                765
Thr Pro Val Leu Lys Leu Met Ala Glu Leu Val His Asn Arg Ser Gln 
     770                775                780
Arg Leu Gln Phe Asp Val Ser Ser Pro Asn Gly Ile Leu Leu Phe Arg 
 785                790                795                800
Glu Thr Ser Lys Met Ile Thr Met Tyr Gly Asn Arg Ile Leu Thr Leu 
                 805                810                815
Gly Glu Val Pro Lys Asp Gln Val Tyr Ala Leu Lys Leu Lys Gly Ile 
             820                825                830
Ser Ile Cys Phe Ser Met Leu Lys Ala Ala Leu Ser Gly Ser Tyr Val 
         835                840                845
Asn Phe Gly Val Phe Arg Leu Tyr Gly Asp Asp Ala Leu Asp Asn Ala 
     850                855                860
Leu Gln Thr Phe Ile Lys Leu Leu Leu Ser Ile Pro His Ser Asp Leu 
 865                870                875                880
Leu Asp Tyr Pro Lys Leu Ser Gln Ser Tyr Tyr Ser Leu Leu Glu Val 
                 885                890                895
Leu Thr Gln Asp His Met Asn Phe Ile Ala Ser Leu Glu Pro His Val 
             900                905                910
Ile Met Tyr Ile Leu Ser Ser Ile Ser Glu Gly Leu Thr Ala Leu Asp 
         915                920                925
Thr Met Val Cys Thr Gly Cys Cys Ser Cys Leu Asp His Ile Val Thr 
     930                935                940
Tyr Leu Phe Lys Gln Leu Ser Arg Ser Thr Lys Lys Arg Thr Thr Pro 
 945                950                955                960
Leu Asn Gln Glu Ser Asp Arg Phe Leu His Ile Met Gln Gln His Pro 
                 965                970                975
Glu Met Ile Gln Gln Met Leu Ser Thr Val Leu Asn Ile Ile Ile Phe 
             980                985                990
Glu Asp Cys Arg Asn Gln Trp Ser Met Ser Arg Pro Leu Leu Gly Leu 
         995                1000                1005
Ile Leu Leu Asn Glu Lys Tyr Phe Ser Asp Leu Arg Asn Ser Ile Val 
     1010                1015                1020
Asn Ser Gln Pro Pro Glu Lys Gln Gln Ala Met His Leu Cys Phe Glu 
 1025                1030                1035                1040
Asn Leu Met Glu Gly Ile Glu Arg Asn Leu Leu Thr Lys Asn Arg Asp 
                 1045                1050                1055
Arg Phe Thr Gln Asn Leu Ser Ala Phe Arg Arg Glu Val Asn Asp Ser 
             1060                1065                1070
Met Lys Asn Ser Thr Tyr Gly Val Asn Ser Asn Asp Met Met Ser 
         1075                1080                1085



<210> 4674
<211> 590
<212> DNA
<213> Rattus norvegicus
<308> AA800671
<400> 4674

acataaaac  attttcaaa  aatacattt  aaaaccatc  agatactga  tttatagca  60
tacaaaaaa  ttgagaggc  caattgaag  attcaaata  aaggtgaag  tgaaggtgg  120
ggtctctac  tgctatcca  tgtgtttcc  gggactcct  ctacaggag  cttcccatg  180
ggcagtagt  cactttgaa  aaatcgaat  aatcacata  aatatatac  tttatacag  240
aagtgttgc  gtgtcatca  tttcaattg  ttataaaaa  cttcatttt  aattgcaca  300
aagttctct  taaaaccgg  aattcccag  aggcagggc  tagaactat  tgtctaaat  360
attcattac  aattaatta  atctctatt  ctccacaga  aaaaaaaaa  caatctgtg  420
agaattaca  catttaagt  ggacattta  aaatttttt  tcataggaa  ataggttta  480
acatttgtc  ctagtcagc  caactttct  cccctactt  aaaacaaat  acagggcgt  540
cagaacttt  cagacggag  acctgtgcc  cagtactgg  tgtgtcccat  590



<210> 4675
<211> 1575
<212> PRT
<213> Rattus norvegicus
<308> NP_006624
<400> 4675

Met Pro His Glu Glu Leu Pro Ser Leu Gln Arg Pro Arg Tyr Gly Ser 
  1               5                  10                  15
Ile Val Asp Asp Glu Arg Leu Ser Ala Glu Glu Met Asp Glu Arg Arg 
             20                  25                  30
Arg Gln Asn Ile Ala Tyr Glu Tyr Leu Cys His Leu Glu Glu Ala Lys 
         35                  40                  45
Arg Trp Met Glu Val Cys Leu Val Glu Glu Leu Pro Pro Thr Thr Glu 
     50                  55                  60
Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys Leu Ala Lys 
 65                  70                  75                  80
Phe Phe Ala Pro Lys Met Val Ser Glu Lys Lys Ile Tyr Asp Val Glu 
                 85                  90                  95
Gln Thr Arg Tyr Lys Lys Ser Gly Leu His Phe Arg His Thr Asp Asn 
             100                105                110
Thr Val Gln Trp Leu Arg Ala Met Glu Ser Ile Gly Leu Pro Lys Ile 
         115                120                125
Phe Tyr Pro Glu Thr Thr Asp Val Tyr Asp Arg Lys Asn Ile Pro Arg 
     130                135                140
Met Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe Lys Leu Gly 
 145                150                155                160
Ile Ala Pro Gln Ile Gln Asp Leu Leu Gly Lys Val Asp Phe Thr Glu 
                 165                170                175
Glu Glu Ile Ser Asn Met Arg Lys Glu Leu Glu Lys Tyr Gly Ile Gln 
             180                185                190
Met Pro Ser Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn Glu Leu Ser 
         195                200                205
Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile Asn Glu Ala 
     210                215                220
Val Glu Lys Gly Ile Ala Glu Gln Thr Val Val Thr Leu Arg Asn Pro 
 225                230                235                240
Asn Ala Val Leu Thr Leu Val Asp Asp Asn Leu Ala Pro Glu Tyr Gln 
                 245                250                255
Lys Glu Leu Trp Asp Ala Lys Lys Lys Lys Glu Glu Asn Ala Arg Leu 
             260                265                270
Lys Asn Ser Cys Ile Ser Glu Glu Glu Arg Asp Ala Tyr Glu Glu Leu 
         275                280                285
Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn Arg Gln 
     290                295                300
Ala Ala Val Asp His Ile Asn Ala Val Ile Pro Glu Gly Asp Pro Glu 
 305                310                315                320
Asn Thr Leu Leu Ala Leu Lys Lys Pro Glu Ala Gln Leu Pro Ala Val 
                 325                330                335
Tyr Pro Phe Ala Ala Ala Met Tyr Gln Asn Glu Leu Phe Asn Leu Gln 
             340                345                350
Lys Gln Asn Thr Met Asn Tyr Leu Ala His Glu Glu Leu Leu Ile Ala 
         355                360                365
Val Glu Met Leu Ser Ala Val Ala Leu Leu Asn Gln Ala Leu Glu Ser 
     370                375                380
Asn Asp Leu Val Ser Val Gln Asn Gln Leu Arg Ser Pro Ala Ile Gly 
 385                390                395                400
Leu Asn Asn Leu Asp Lys Ala Tyr Val Glu Arg Tyr Ala Asn Thr Leu 
                 405                410                415
Leu Ser Val Lys Leu Glu Val Leu Ser Gln Gly Gln Asp Asn Leu Ser 
             420                425                430
Trp Asn Glu Ile Gln Asn Cys Ile Asp Met Val Asn Ala Gln Ile Gln 
         435                440                445
Glu Glu Asn Asp Arg Val Val Ala Val Gly Tyr Ile Asn Glu Ala Ile 
     450                455                460
Asp Glu Gly Asn Pro Leu Arg Thr Leu Glu Thr Leu Leu Leu Pro Thr 
 465                470                475                480
Ala Asn Ile Ser Asp Val Asp Pro Ala His Ala Gln His Tyr Gln Asp 
                 485                490                495
Val Leu Tyr His Ala Lys Ser Gln Lys Leu Gly Asp Ser Glu Ser Val 
             500                505                510
Ser Lys Val Leu Trp Leu Asp Glu Ile Gln Gln Ala Val Asp Glu Ala 
         515                520                525
Asn Val Asp Glu Asp Arg Ala Lys Gln Trp Val Thr Leu Val Val Asp 
     530                535                540
Val Asn Gln Cys Leu Glu Gly Lys Lys Ser Ser Asp Ile Leu Ser Val 
 545                550                555                560
Leu Lys Ser Ser Thr Ser Asn Ala Asn Asp Ile Ile Pro Glu Cys Ala 
                 565                570                575
Asp Lys Tyr Tyr Asp Ala Leu Val Lys Ala Lys Glu Leu Lys Ser Glu 
             580                585                590
Arg Val Ser Ser Asp Gly Ser Trp Leu Lys Leu Asn Leu His Lys Lys 
         595                600                605
Tyr Asp Tyr Tyr Tyr Asn Thr Asp Ser Lys Glu Ser Ser Trp Val Thr 
     610                615                620
Pro Glu Ser Cys Phe Tyr Lys Glu Ser Trp Leu Thr Gly Lys Glu Ile 
 625                630                635                640
Glu Asp Ile Ile Glu Glu Val Thr Val Gly Tyr Ile Arg Glu Asn Ile 
                 645                650                655
Trp Ser Ala Ser Glu Glu Leu Leu Leu Arg Phe Gln Ala Thr Ser Ser 
             660                665                670
Gly Pro Ile Leu Arg Glu Glu Phe Glu Ala Arg Lys Ser Phe Leu His 
         675                680                685
Glu Gln Glu Glu Asn Val Val Lys Ile Gln Ala Phe Trp Lys Gly Tyr 
     690                695                700
Lys Gln Arg Lys Glu Tyr Met His Arg Arg Gln Thr Phe Ile Asp Asn 
 705                710                715                720
Thr Asp Ser Val Val Lys Ile Gln Ser Trp Phe Arg Met Ala Thr Ala 
                 725                730                735
Arg Lys Ser Tyr Leu Ser Arg Leu Gln Tyr Phe Arg Asp His Asn Asn 
             740                745                750
Glu Ile Val Lys Ile Gln Ser Leu Leu Arg Ala Asn Lys Ala Arg Asp 
         755                760                765
Asp Tyr Lys Thr Leu Val Gly Ser Glu Asn Pro Pro Leu Thr Val Ile 
     770                775                780
Arg Lys Phe Val Tyr Leu Leu Asp Gln Ser Asp Leu Asp Phe Gln Glu 
 785                790                795                800
Glu Leu Glu Val Ala Arg Leu Arg Glu Glu Val Val Thr Lys Ile Arg 
                 805                810                815
Ala Asn Gln Gln Leu Glu Lys Asp Leu Asn Leu Met Asp Ile Lys Ile 
             820                825                830
Gly Leu Leu Val Lys Asn Arg Ile Thr Leu Glu Asp Val Ile Ser His 
         835                840                845
Ser Lys Lys Leu Asn Lys Lys Lys Gly Gly Glu Met Glu Ile Leu Asn 
     850                855                860
Asn Thr Asp Asn Gln Gly Ile Lys Ser Leu Ser Lys Glu Arg Arg Lys 
 865                870                875                880
Thr Leu Glu Thr Tyr Gln Gln Leu Phe Tyr Leu Leu Gln Thr Asn Pro 
                 885                890                895
Leu Tyr Leu Ala Lys Leu Ile Phe Gln Met Pro Gln Asn Lys Ser Thr 
             900                905                910
Lys Phe Met Asp Thr Val Ile Phe Thr Leu Tyr Asn Tyr Ala Ser Asn 
         915                920                925
Gln Arg Glu Glu Tyr Leu Leu Leu Lys Leu Phe Lys Thr Ala Leu Glu 
     930                935                940
Glu Glu Ile Lys Ser Lys Val Asp Gln Val Gln Asp Ile Val Thr Gly 
 945                950                955                960
Asn Pro Thr Val Ile Lys Met Val Val Ser Phe Asn Arg Gly Ala Arg 
                 965                970                975
Gly Gln Asn Thr Leu Arg Gln Leu Leu Ala Pro Val Val Lys Glu Ile 
             980                985                990
Ile Asp Asp Lys Ser Leu Ile Ile Asn Thr Asn Pro Val Glu Val Tyr 
         995                1000                1005
Lys Ala Trp Val Asn Gln Leu Glu Thr Gln Thr Gly Glu Ala Ser Lys 
     1010                1015                1020
Leu Pro Tyr Asp Val Thr Thr Glu Gln Ala Leu Thr Tyr Pro Glu Val 
 1025                1030                1035                1040
Lys Asn Lys Leu Glu Ala Ser Ile Glu Asn Leu Arg Arg Val Thr Asp 
                 1045                1050                1055
Lys Val Leu Asn Ser Ile Ile Ser Ser Leu Asp Leu Leu Pro Tyr Gly 
             1060                1065                1070
Leu Arg Tyr Ile Ala Lys Val Leu Lys Asn Ser Ile His Glu Lys Phe 
         1075                1080                1085
Pro Asp Ala Thr Glu Asp Glu Leu Leu Lys Ile Val Gly Asn Leu Leu 
     1090                1095                1100
Tyr Tyr Arg Tyr Met Asn Pro Ala Ile Val Ala Pro Asp Gly Phe Asp 
 1105                1110                1115                1120
Ile Ile Asp Met Thr Ala Gly Gly Gln Ile Asn Ser Asp Gln Arg Arg 
                 1125                1130                1135
Asn Leu Gly Ser Val Ala Lys Val Leu Gln His Ala Ala Ser Asn Lys 
             1140                1145                1150
Leu Phe Glu Gly Glu Asn Glu His Leu Ser Ser Met Asn Asn Tyr Leu 
         1155                1160                1165
Ser Glu Thr Tyr Gln Glu Phe Arg Lys Tyr Phe Lys Glu Ala Cys Asn 
     1170                1175                1180
Val Pro Glu Pro Glu Glu Lys Phe Asn Met Asp Lys Tyr Thr Asp Leu 
 1185                1190                1195                1200
Val Thr Val Ser Lys Pro Val Ile Tyr Ile Ser Ile Glu Glu Ile Ile 
                 1205                1210                1215
Ser Thr His Ser Leu Leu Leu Glu His Gln Asp Ala Ile Ala Pro Glu 
             1220                1225                1230
Lys Asn Asp Leu Leu Ser Glu Leu Leu Gly Ser Leu Gly Glu Val Pro 
         1235                1240                1245
Thr Val Glu Ser Phe Leu Gly Glu Gly Ala Val Asp Pro Asn Asp Pro 
     1250                1255                1260
Asn Lys Ala Asn Thr Leu Ser Gln Leu Ser Lys Thr Glu Ile Ser Leu 
 1265                1270                1275                1280
Val Leu Thr Ser Lys Tyr Asp Ile Glu Asp Gly Glu Ala Ile Asp Ser 
                 1285                1290                1295
Arg Ser Leu Met Ile Lys Thr Lys Lys Leu Ile Ile Asp Val Ile Arg 
             1300                1305                1310
Asn Gln Pro Gly Asn Thr Leu Thr Glu Ile Leu Glu Thr Pro Ala Thr 
         1315                1320                1325
Ala Gln Gln Glu Val Asp His Ala Thr Asp Met Val Ser Arg Ala Met 
     1330                1335                1340
Ile Asp Ser Arg Thr Pro Glu Glu Met Lys His Ser Gln Ser Met Ile 
 1345                1350                1355                1360
Glu Asp Ala Gln Leu Pro Leu Glu Gln Lys Lys Arg Lys Ile Gln Arg 
                 1365                1370                1375
Asn Leu Arg Thr Leu Glu Gln Thr Gly His Val Ser Ser Glu Asn Lys 
             1380                1385                1390
Tyr Gln Asp Ile Leu Asn Glu Ile Ala Lys Asp Ile Arg Asn Gln Arg 
         1395                1400                1405
Ile Tyr Arg Lys Leu Arg Lys Ala Glu Leu Ala Lys Leu Gln Gln Thr 
     1410                1415                1420
Leu Asn Ala Leu Asn Lys Lys Ala Ala Phe Tyr Glu Glu Gln Ile Asn 
 1425                1430                1435                1440
Tyr Tyr Asp Thr Tyr Ile Lys Thr Cys Leu Asp Asn Leu Lys Arg Lys 
                 1445                1450                1455
Asn Thr Arg Arg Ser Ile Lys Leu Asp Gly Lys Gly Glu Pro Lys Gly 
             1460                1465                1470
Ala Lys Arg Ala Lys Pro Val Lys Tyr Thr Ala Ala Lys Leu His Glu 
         1475                1480                1485
Lys Gly Val Leu Leu Asp Ile Asp Asp Leu Gln Thr Asn Gln Phe Lys 
     1490                1495                1500
Asn Val Thr Phe Asp Ile Ile Ala Thr Glu Asp Val Gly Ile Phe Asp 
 1505                1510                1515                1520
Val Arg Ser Lys Phe Leu Gly Val Glu Met Glu Lys Val Gln Leu Asn 
                 1525                1530                1535
Ile Gln Asp Leu Leu Gln Met Gln Tyr Glu Gly Val Ala Val Met Lys 
             1540                1545                1550
Met Phe Asp Lys Val Lys Val Asn Val Asn Leu Leu Ile Tyr Leu Leu 
         1555                1560                1565
Asn Lys Lys Phe Tyr Gly Lys 
     1570                1575



<210> 4676
<211> 5767
<212> DNA
<213> Homo sapiens
<308> U51903
<400> 4676

gagggagga  agttcactt  tacttcagt  tcagcgcgc  gcggccgtg  ctggctctg  60
cgagagagc  ccgagggag  gggtcgcag  tcttcgggc  gctagggga  atcggcgag  120
ggcgggatc  gagcgcgcc  gcggggcgc  gagcccgcg  gcctggcca  cgagggtag  180
cgcgggggg  gcgccccgg  cgggccccc  gagacgcgc  ggatgccac  cgaagagct  240
ccgtcgctg  agagacccc  ctatggctc  attgtggac  atgaaaggc  ctctgcaga  300
gagatggat  agaggaggc  gcagaacat  gcttatgaa  atctgtgcc  cttagagga  360
gccaaaagg  ggatggaag  ttgcttagt  gaagaattg  caccaacca  tgaattgga  420
gaagggctc  ggaatggag  ttaccttgc  aagttagcc  agttctttg  cccgaaaat  480
gtatcagag  aaaagatct  tgatgtgga  caaacacgt  ataagaagt  tggccttca  540
tttcgacac  cagataata  cgtccagtg  ttaagagcg  tggagtcta  tggtctacc  600
aagatattt  atccagaaa  aacagatgt  tatgatcgg  aaaacatac  aagaatgat  660
tattgcatt  acgcactga  tttgtatct  ttcaaacta  gaatagcac  ccagatcca  720
gatttgttg  gcaaagtag  cttcacaga  gaggaaatc  gtaatatga  aaaagaact  780
gagaaatat  gaatacaga  gccatcttt  agcaaaata  gtggtattc  ggccaatga  840
ctgtccgtg  atgaagctg  attacatgc  gcagttata  ccattaatg  agcagttga  900
aaaggaata  cagagcaaa  cgttgtaac  ctaagaaac  caaatgcgg  tttaacttt  960
gtggatgac  accttgcac  agaatatca  aaagaactc  gggatgcca  aaagaaaaa  1020
gaggaaaat  caagactga  gaatagctg  atttcagaa  aagaaagag  tgcttatga  1080
gaactgctg  cacaagcag  aatccaagg  aatattaat  aagtcaaca  gcaggctgc  1140
gtggaccat  tcaatgctg  cattccgga  ggtgacccc  agaatacgc  gcttgcact  1200
aagaaacca  aggcccagc  gcctgctgt  tatcccttt  ctgctgcca  gtatcagaa  1260
gaacttttc  acctccaga  acagaacac  atgaactac  tggcccacg  ggagctttt  1320
attgctgtg  aaatgttgt  tgctgttgc  ttactaaac  aggccttgg  aagcaacga  1380
cttgtgtct  tgcagaatc  actcagaag  cccgcaata  gcttaaaca  tctggacaa  1440
gcatatgtg  aacgttatg  aaacacact  ctctctgtt  aactagaag  tttatccca  1500
gggcaagat  acttaagct  gaatgaaat  cagaattgt  ttgatatgg  taatgctca  1560
attcaagaa  aaaatgacc  agttgtagc  gtagggtac  tcaatgaag  tattgatga  1620
gggaatcct  tgaggactt  agaaacttt  ctcctacct  ctgcgaata  tagtgatgt  1680
gacccagcc  atgcccagc  ctaccagga  gttttatac  atgctaaat  acagaaact  1740
ggagactct  agagtgttt  caaagtgct  tggctggat  agatacagc  agccgtcga  1800
gaggccaac  tggacgagg  cagagcaaa  caatgggtt  ctctggtgg  tgatgttaa  1860
cagtgtttg  aaggaaaaa  atcaagtga  attttgtct  tattgaagt  ttccacttc  1920
aatgcaaat  acataatcc  ggagtgtgc  gacaaatac  atgatgccc  tgtgaaggc  1980
aaagagctc  aatctgaaa  agtgtctag  gacggttca  ggctcaaac  caacctgca  2040
aaaaaatat  actactatt  caacactga  tcaaaagag  gttcctggg  cacacctga  2100
tcatgcttc  ataaagaat  atggctcac  ggaaaagaa  tcgaggaca  tattgagga  2160
gtcacagta  gttacattc  tgagaatat  tggtctgct  cagaagagt  gcttcttcg  2220
tttcaagcc  caagctcag  acccatcct  agggaagag  ttgaagcta  aaaatcatt  2280
ttgcatgaa  aagaagaga  tgtggtcaa  atacaggct  tttggaaag  atataaaca  2340
cggaaggag  atatgcaca  gcggcaaac  ttcattgat  atactgatt  tgttgtgaa  2400
attcagtcc  ggttccgaa  ggcaactgc  agaaagagc  atctttcaa  actacagta  2460
ttcagagat  ataataatg  aattgtgaa  atacagtca  tgttgagag  gaacaaagc  2520
agagatgac  acaaaacat  ggttggctc  gaaaaccca  cattaacag  aattcgcaa  2580
tttgtatac  tgctggacc  aagtgattt  gatttccag  aggaactag  ggttgcacg  2640
ttaagggaa  aagtagtga  caagatcag  gccaatcaa  agctggaaa  agacctgaa  2700
ctgatggac  tcaagattg  actgctggt  aagaacagg  tcacactag  ggatgtaat  2760
tcacacagt  aaaagctga  caagaaaaa  ggaggagaa  tggaaatac  gaataacac  2820
gacaaccaa  gaataaaaa  tttgagtaa  gagaggaga  aaacactag  aacatatca  2880
cagctgttt  accttttac  gaccaaccc  ttatacttg  ctaagctga  tttccagat  2940
ccacagaac  agtccacta  atttatgga  actgttatt  tcacactat  taattatgc  3000
tctaatcag  gagaagaat  tctacttct  aagcttttt  aaactgctc  ggaggaaga  3060
ataaaatca  aagtggacc  ggtacagga  atagttact  gtaacccta  agtcatcaa  3120
atggtcgtc  gcttcaata  aggtgcccg  ggacagaac  ccctgcgcc  actcctggc  3180
ccagtggta  aagagatca  cgacgacaa  tcgctgatt  tcaacacaa  ccctgtaga  3240
gtgtacaag  cttgggtga  ccaactaga  acacagact  gagaggcca  caagttgcc  3300
tatgatgtg  ccacagaac  agctctaac  tacccagaa  tgaaaaata  actggaggc  3360
tccattgag  acctgagaa  ggtcaccga  aaagtcctg  attctatca  ttcttccct  3420
gatctactg  cttatggat  gaggtatat  gccaaagta  tgaagaatt  gatccatga  3480
aaattcccc  atgcaacag  agatgagct  ttaaagatt  ttggaaacc  cctgtacta  3540
cggtacatg  atccagcca  tgtagctcc  gatggcttt  atatcatcg  catgacagc  3600
ggaggtcag  taaattctg  ccaaaggag  aacttagga  cagtggcca  ggttcttca  3660
cacgcagcc  ccaacaagc  gtttgaagg  gaaaatgag  atctctcat  tatgaacaa  3720
tatttatca  agacgtatc  ggaattcag  aaatatttc  aagaagcat  taatgtccc  3780
gagccagaa  agaagttta  tatggacaa  tacacagac  tggtgacag  cagcaaacc  3840
gtcatttat  tttcaattg  agaaatcat  agcacacac  cactcctgt  ggaacacca  3900
gatgcaatt  cccctgaga  aaatgactt  ctgagtgaa  tgctggggt  gctgggaga  3960
gtgccaacc  tggaatctt  tcttgggga  ggagcagtt  accccaatg  ccctaacaa  4020
gcaaataca  taagtcagc  ttcaaagac  gagatttct  ttgtcttga  aagcaaata  4080
gacatagag  acggtgaag  tatagatag  cgaagcctc  tgataaaga  caagaagct  4140
ataattgat  tgatccgga  ccagccagg  aacacattg  cagaaatct  agagacacc  4200
gcaactgcg  aacaggagg  agaccatgc  acggacatg  tgagccgtg  aatgataga  4260
tccaggact  cagaagaaa  gaagcatag  caatctatg  ttgaagatg  acagctgcc  4320
cttgagcag  agaagagga  aatccagag  aatcttcgg  cgttggaac  gactggaca  4380
gtgtcatcc  aaaataaat  ccaagacat  ctcaatgag  ttgccaagg  tattcgaaa  4440
caaagaatc  atcgtaagc  tcgaaaagc  gaattggca  aacttcagc  gaccctgaa  4500
gcacttaac  agaaggcag  attttatga  gagcaaatc  attattatg  cacctacat  4560
aagacttgt  tagacaact  aaaaagaaa  aatactcgg  gatcaatta  actagatgg  4620
aaaggagaa  ccaaagggg  gaagagagc  aagccagtg  agtacactg  agcaaagct  4680
catgagaaa  gtgtcctgc  agatataga  gatcttcaa  caaaccagt  taagaatgt  4740
acatttgat  tcatagcta  tgaagatgt  ggcattttc  atgtaagat  aaaattcct  4800
ggtgttgag  tggaaaagg  gcaactcaa  attcaggat  tacttcaga  gcaatatga  4860
ggagtagct  taatgaaaa  gtttgataa  gttaaagtg  atgtaaacc  tctcatata  4920
ctgctgaac  agaagttct  tggaaagtg  agtgcctac  gaaatttct  ggattctgt  4980
tcatctgga  taggaaatg  atttgttta  tatttttgt  tttaaacat  attgaaatc  5040
ctgcttata  atgtgtgat  ttttttaaa  gaccaaaac  gttctgaag  atgtaccca  5100
gtgcctttt  gctaatttg  tactataat  gaatgagac  taaaatgaa  taatggaaa  5160
atatccaca  tgtactgtg  tataggtac  ctgatttaa  actttggac  tcctgtgat  5220
tgttttaaa  ttggggggt  ggaaattta  ctgactagg  acaaacatg  aaacctatt  5280
tcctatgaa  aaagtttta  atgtcccac  tgaataacg  aattcttca  agttttttt  5340
atctatgga  aaatggaaa  ctaattatt  gtaatgaat  atttagaca  ttctaagcc  5400
tgtcttctg  gagttatca  ttttaaaga  aacttttgt  caattcaaa  gaagttttt  5460
taagtaatt  aaaatgaca  cacaataac  ctttctgta  aaaagtata  attttatgt  5520
atttattcc  actaaatga  agtgcacta  tgcctcatg  aaagactct  gcacgcaga  5580
cctttaagt  actaaggaa  aacatagat  gtgagcata  tccccacct  cacccctca  5640
aatttattt  aatacttca  ttgtgcctc  caatttttt  taatgctaa  aaatcagta  5700
ctagatggt  tttaaatgt  ttctctgga  attgtttta  gtaaaataa  tgttactta  5760
ttccatt  5767



<210> 4677
<211> 1575
<212> PRT
<213> Homo sapiens
<308> Q13576
<400> 4677

Met Pro His Glu Glu Leu Pro Ser Leu Gln Arg Pro Arg Tyr Gly Ser 
  1               5                  10                  15
Ile Val Asp Asp Glu Arg Leu Ser Ala Glu Glu Met Asp Glu Arg Arg 
             20                  25                  30
Arg Gln Asn Ile Ala Tyr Glu Tyr Leu Cys His Leu Glu Glu Ala Lys 
         35                  40                  45
Arg Trp Met Glu Val Cys Leu Val Glu Glu Leu Pro Pro Thr Thr Glu 
     50                  55                  60
Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys Leu Ala Lys 
 65                  70                  75                  80
Phe Phe Ala Pro Lys Met Val Ser Glu Lys Lys Ile Tyr Asp Val Glu 
                 85                  90                  95
Gln Thr Arg Tyr Lys Lys Ser Gly Leu His Phe Arg His Thr Asp Asn 
             100                105                110
Thr Val Gln Trp Leu Arg Ala Met Glu Ser Ile Gly Leu Pro Lys Ile 
         115                120                125
Phe Tyr Pro Glu Thr Thr Asp Val Tyr Asp Arg Lys Asn Ile Pro Arg 
     130                135                140
Met Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe Lys Leu Gly 
 145                150                155                160
Ile Ala Pro Gln Ile Gln Asp Leu Leu Gly Lys Val Asp Phe Thr Glu 
                 165                170                175
Glu Glu Ile Ser Asn Met Arg Lys Glu Leu Glu Lys Tyr Gly Ile Gln 
             180                185                190
Met Pro Ser Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn Glu Leu Ser 
         195                200                205
Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile Asn Glu Ala 
     210                215                220
Val Glu Lys Gly Ile Ala Glu Gln Thr Val Val Thr Leu Arg Asn Pro 
 225                230                235                240
Asn Ala Val Leu Thr Leu Val Asp Asp Asn Leu Ala Pro Glu Tyr Gln 
                 245                250                255
Lys Glu Leu Trp Asp Ala Lys Lys Lys Lys Glu Glu Asn Ala Arg Leu 
             260                265                270
Lys Asn Ser Cys Ile Ser Glu Glu Glu Arg Asp Ala Tyr Glu Glu Leu 
         275                280                285
Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn Arg Gln 
     290                295                300
Ala Ala Val Asp His Ile Asn Ala Val Ile Pro Glu Gly Asp Pro Glu 
 305                310                315                320
Asn Thr Leu Leu Ala Leu Lys Lys Pro Glu Ala Gln Leu Pro Ala Val 
                 325                330                335
Tyr Pro Phe Ala Ala Ala Met Tyr Gln Asn Glu Leu Phe Asn Leu Gln 
             340                345                350
Lys Gln Asn Thr Met Asn Tyr Leu Ala His Glu Glu Leu Leu Ile Ala 
         355                360                365
Val Glu Met Leu Ser Ala Val Ala Leu Leu Asn Gln Ala Leu Glu Ser 
     370                375                380
Asn Asp Leu Val Ser Val Gln Asn Gln Leu Arg Ser Pro Ala Ile Gly 
 385                390                395                400
Leu Asn Asn Leu Asp Lys Ala Tyr Val Glu Arg Tyr Ala Asn Thr Leu 
                 405                410                415
Leu Ser Val Lys Leu Glu Val Leu Ser Gln Gly Gln Asp Asn Leu Ser 
             420                425                430
Trp Asn Glu Ile Gln Asn Cys Ile Asp Met Val Asn Ala Gln Ile Gln 
         435                440                445
Glu Glu Asn Asp Arg Val Val Ala Val Gly Tyr Ile Asn Glu Ala Ile 
     450                455                460
Asp Glu Gly Asn Pro Leu Arg Thr Leu Glu Thr Leu Leu Leu Pro Thr 
 465                470                475                480
Ala Asn Ile Ser Asp Val Asp Pro Ala His Ala Gln His Tyr Gln Asp 
                 485                490                495
Val Leu Tyr His Ala Lys Ser Gln Lys Leu Gly Asp Ser Glu Ser Val 
             500                505                510
Ser Lys Val Leu Trp Leu Asp Glu Ile Gln Gln Ala Val Asp Glu Ala 
         515                520                525
Asn Val Asp Glu Asp Arg Ala Lys Gln Trp Val Thr Leu Val Val Asp 
     530                535                540
Val Asn Gln Cys Leu Glu Gly Lys Lys Ser Ser Asp Ile Leu Ser Val 
 545                550                555                560
Leu Lys Ser Ser Thr Ser Asn Ala Asn Asp Ile Ile Pro Glu Cys Ala 
                 565                570                575
Asp Lys Tyr Tyr Asp Ala Leu Val Lys Ala Lys Glu Leu Lys Ser Glu 
             580                585                590
Arg Val Ser Ser Asp Gly Ser Trp Leu Lys Leu Asn Leu His Lys Lys 
         595                600                605
Tyr Asp Tyr Tyr Tyr Asn Thr Asp Ser Lys Glu Ser Ser Trp Val Thr 
     610                615                620
Pro Glu Ser Cys Phe Tyr Lys Glu Ser Trp Leu Thr Gly Lys Glu Ile 
 625                630                635                640
Glu Asp Ile Ile Glu Glu Val Thr Val Gly Tyr Ile Arg Glu Asn Ile 
                 645                650                655
Trp Ser Ala Ser Glu Glu Leu Leu Leu Arg Phe Gln Ala Thr Ser Ser 
             660                665                670
Gly Pro Ile Leu Arg Glu Glu Phe Glu Ala Arg Lys Ser Phe Leu His 
         675                680                685
Glu Gln Glu Glu Asn Val Val Lys Ile Gln Ala Phe Trp Lys Gly Tyr 
     690                695                700
Lys Gln Arg Lys Glu Tyr Met His Arg Arg Gln Thr Phe Ile Asp Asn 
 705                710                715                720
Thr Asp Ser Val Val Lys Ile Gln Ser Trp Phe Arg Met Ala Thr Ala 
                 725                730                735
Arg Lys Ser Tyr Leu Ser Arg Leu Gln Tyr Phe Arg Asp His Asn Asn 
             740                745                750
Glu Ile Val Lys Ile Gln Ser Leu Leu Arg Ala Asn Lys Ala Arg Asp 
         755                760                765
Asp Tyr Lys Thr Leu Val Gly Ser Glu Asn Pro Pro Leu Thr Val Ile 
     770                775                780
Arg Lys Phe Val Tyr Leu Leu Asp Gln Ser Asp Leu Asp Phe Gln Glu 
 785                790                795                800
Glu Leu Glu Val Ala Arg Leu Arg Glu Glu Val Val Thr Lys Ile Arg 
                 805                810                815
Ala Asn Gln Gln Leu Glu Lys Asp Leu Asn Leu Met Asp Ile Lys Ile 
             820                825                830
Gly Leu Leu Val Lys Asn Arg Ile Thr Leu Glu Asp Val Ile Ser His 
         835                840                845
Ser Lys Lys Leu Asn Lys Lys Lys Gly Gly Glu Met Glu Ile Leu Asn 
     850                855                860
Asn Thr Asp Asn Gln Gly Ile Lys Ser Leu Ser Lys Glu Arg Arg Lys 
 865                870                875                880
Thr Leu Glu Thr Tyr Gln Gln Leu Phe Tyr Leu Leu Gln Thr Asn Pro 
                 885                890                895
Leu Tyr Leu Ala Lys Leu Ile Phe Gln Met Pro Gln Asn Lys Ser Thr 
             900                905                910
Lys Phe Met Asp Thr Val Ile Phe Thr Leu Tyr Asn Tyr Ala Ser Asn 
         915                920                925
Gln Arg Glu Glu Tyr Leu Leu Leu Lys Leu Phe Lys Thr Ala Leu Glu 
     930                935                940
Glu Glu Ile Lys Ser Lys Val Asp Gln Val Gln Asp Ile Val Thr Gly 
 945                950                955                960
Asn Pro Thr Val Ile Lys Met Val Val Ser Phe Asn Arg Gly Ala Arg 
                 965                970                975
Gly Gln Asn Thr Leu Arg Gln Leu Leu Ala Pro Val Val Lys Glu Ile 
             980                985                990
Ile Asp Asp Lys Ser Leu Ile Ile Asn Thr Asn Pro Val Glu Val Tyr 
         995                1000                1005
Lys Ala Trp Val Asn Gln Leu Glu Thr Gln Thr Gly Glu Ala Ser Lys 
     1010                1015                1020
Leu Pro Tyr Asp Val Thr Thr Glu Gln Ala Leu Thr Tyr Pro Glu Val 
 1025                1030                1035                1040
Lys Asn Lys Leu Glu Ala Ser Ile Glu Asn Leu Arg Arg Val Thr Asp 
                 1045                1050                1055
Lys Val Leu Asn Ser Ile Ile Ser Ser Leu Asp Leu Leu Pro Tyr Gly 
             1060                1065                1070
Leu Arg Tyr Ile Ala Lys Val Leu Lys Asn Ser Ile His Glu Lys Phe 
         1075                1080                1085
Pro Asp Ala Thr Glu Asp Glu Leu Leu Lys Ile Val Gly Asn Leu Leu 
     1090                1095                1100
Tyr Tyr Arg Tyr Met Asn Pro Ala Ile Val Ala Pro Asp Gly Phe Asp 
 1105                1110                1115                1120
Ile Ile Asp Met Thr Ala Gly Gly Gln Ile Asn Ser Asp Gln Arg Arg 
                 1125                1130                1135
Asn Leu Gly Ser Val Ala Lys Val Leu Gln His Ala Ala Ser Asn Lys 
             1140                1145                1150
Leu Phe Glu Gly Glu Asn Glu His Leu Ser Ser Met Asn Asn Tyr Leu 
         1155                1160                1165
Ser Glu Thr Tyr Gln Glu Phe Arg Lys Tyr Phe Lys Glu Ala Cys Asn 
     1170                1175                1180
Val Pro Glu Pro Glu Glu Lys Phe Asn Met Asp Lys Tyr Thr Asp Leu 
 1185                1190                1195                1200
Val Thr Val Ser Lys Pro Val Ile Tyr Ile Ser Ile Glu Glu Ile Ile 
                 1205                1210                1215
Ser Thr His Ser Leu Leu Leu Glu His Gln Asp Ala Ile Ala Pro Glu 
             1220                1225                1230
Lys Asn Asp Leu Leu Ser Glu Leu Leu Gly Ser Leu Gly Glu Val Pro 
         1235                1240                1245
Thr Val Glu Ser Phe Leu Gly Glu Gly Ala Val Asp Pro Asn Asp Pro 
     1250                1255                1260
Asn Lys Ala Asn Thr Leu Ser Gln Leu Ser Lys Thr Glu Ile Ser Leu 
 1265                1270                1275                1280
Val Leu Thr Ser Lys Tyr Asp Ile Glu Asp Gly Glu Ala Ile Asp Ser 
                 1285                1290                1295
Arg Ser Leu Met Ile Lys Thr Lys Lys Leu Ile Ile Asp Val Ile Arg 
             1300                1305                1310
Asn Gln Pro Gly Asn Thr Leu Thr Glu Ile Leu Glu Thr Pro Ala Thr 
         1315                1320                1325
Ala Gln Gln Glu Val Asp His Ala Thr Asp Met Val Ser Arg Ala Met 
     1330                1335                1340
Ile Asp Ser Arg Thr Pro Glu Glu Met Lys His Ser Gln Ser Met Ile 
 1345                1350                1355                1360
Glu Asp Ala Gln Leu Pro Leu Glu Gln Lys Lys Arg Lys Ile Gln Arg 
                 1365                1370                1375
Asn Leu Arg Thr Leu Glu Gln Thr Gly His Val Ser Ser Glu Asn Lys 
             1380                1385                1390
Tyr Gln Asp Ile Leu Asn Glu Ile Ala Lys Asp Ile Arg Asn Gln Arg 
         1395                1400                1405
Ile Tyr Arg Lys Leu Arg Lys Ala Glu Leu Ala Lys Leu Gln Gln Thr 
     1410                1415                1420
Leu Asn Ala Leu Asn Lys Lys Ala Ala Phe Tyr Glu Glu Gln Ile Asn 
 1425                1430                1435                1440
Tyr Tyr Asp Thr Tyr Ile Lys Thr Cys Leu Asp Asn Leu Lys Arg Lys 
                 1445                1450                1455
Asn Thr Arg Arg Ser Ile Lys Leu Asp Gly Lys Gly Glu Pro Lys Gly 
             1460                1465                1470
Ala Lys Arg Ala Lys Pro Val Lys Tyr Thr Ala Ala Lys Leu His Glu 
         1475                1480                1485
Lys Gly Val Leu Leu Asp Ile Asp Asp Leu Gln Thr Asn Gln Phe Lys 
     1490                1495                1500
Asn Val Thr Phe Asp Ile Ile Ala Thr Glu Asp Val Gly Ile Phe Asp 
 1505                1510                1515                1520
Val Arg Ser Lys Phe Leu Gly Val Glu Met Glu Lys Val Gln Leu Asn 
                 1525                1530                1535
Ile Gln Asp Leu Leu Gln Met Gln Tyr Glu Gly Val Ala Val Met Lys 
             1540                1545                1550
Met Phe Asp Lys Val Lys Val Asn Val Asn Leu Leu Ile Tyr Leu Leu 
         1555                1560                1565
Asn Lys Lys Phe Tyr Gly Lys 
     1570                1575



<210> 4678
<211> 698
<212> DNA
<213> Rattus norvegicus
<308> AA800673
<400> 4678

gggtaaagg  agtatatgt  tgcagcgta  atcacatcg  atgcagcgt  taacatatg  60
tattaattg  ctaacagtt  ttttcctgg  acttgtatg  aaacagctt  accaagagg  120
tctgtgcag  ttttgtaac  tgtcatgaa  catgtaact  aatggtgat  tcaaagaat  180
catacaggc  actttgtgt  tggctgtga  aaggagaat  ttcacagtg  tgttctact  240
cagttcttc  aacaacccc  ttactagga  gcagtggga  taaaaaaat  gaagaaacc  300
caggtacac  taaatacag  ctggtactc  ctattaagt  agttccagc  atctacttt  360
ctctgttgt  gaaagagta  acctgaaca  gtaccaacg  gaaaattca  tgtataacc  420
agtaactgc  aaaataaaa  ttgtatatt  atggaaaat  gaaatggta  gaaaactat  480
aggggatta  acacattgt  tttgcattt  agttaatct  aactattat  atagttatt  540
taaataact  ttttagttc  ggttgaagc  ataaagttg  tttgcangt  ttttctgat  600
tactgaatg  ttccatggt  aggacnatt  ggaacatcc  ataaactga  taatcatga  660
gaccgttac  agggtaaac  cttcacaag  tgaccttg  698



<210> 4679
<211> 5538
<212> DNA
<213> Homo sapiens
<308> D79986
<400> 4679

gccccagat  ggaagtgac  gagacgtgc  agcgcgtcg  aggtagctc  atggttttc  60
tcgcgttct  gagtcggga  atggccgct  tgtggttgc  acggagata  attcccgga  120
ccgcgattc  gcgtgtcag  aattcgaat  tagagttta  tttctcaga  cattctctc  180
aggaagaat  tttacagta  ctcaaagac  tcacttgac  tcttgatcc  gcataaaac  240
aaggagaaa  gaaatgggt  gctccaatt  tagatcaca  tcttcaagg  caaagtcta  300
atcacagtc  agttctcga  caagatcaa  atctcattc  agaaagaag  gatacagtt  360
taggtctcg  tccagaaca  attcaaggt  tcgtagtag  gatcgtatg  attctagag  420
ttatcgtcg  gattacaga  ataatagag  aatgagacg  ccttatggg  acagaggaa  480
gggtagagg  tattatcaa  gaggaggag  tagatatca  cgaggtggt  atagacctg  540
ctggaatag  aggcactct  ggagtccta  acgaggtcg  tcacgttcc  ggagtccaa  600
aagaagatc  gtttcttct  aaagatcca  aagcagatc  cgccggtca  atagatctt  660
taggtctcc  agatcatcc  cttctcgtt  ttcatcccc  tatagcaaa  ctcctgttt  720
taaaagacg  gggtctcag  aaaaacaaa  caaaaaagc  gaaggggaa  cccaagaag  780
gagtccgtt  aaaagtaaa  cacaggagg  accgaaaga  acatttgaa  atgacccat  840
tgagtctat  gatgaattt  ataagtcat  agccacatc  ggtgatatt  ggcctggcc  900
ttcagctta  gataatagt  ctagatcac  ccatagtcc  tcacctatt  ctacaccac  960
tagtcagag  tcatcttgc  ctgatgctc  catgctcag  acagttcac  ctgcaaaaa  1020
tactccttc  cagcattca  attccattc  gcatagtcc  gaaaggtct  ggtctggtt  1080
tgttggaaa  ggatctagt  gatacagtc  ttctcagaa  agtccaatt  atcacatcc  1140
ttcacgaag  agtcctgca  agacaatcg  accacagaa  gctccaaga  atgagtcta  1200
gggccgttc  tcgttttat  ctgatggtg  agatcagga  actgcaaag  ctgggaagt  1260
cttaaaaag  ttcacagat  aagagtcta  agtattcct  cttgatagg  gtaatacca  1320
ggataaaga  gcttcaaaa  agaaaggat  agagaaagg  agggcagag  gagaatggg  1380
agatcagga  gctctagat  acttcagtg  taaagagtc  ggaaaacaa  agtttaatg  1440
ttcagaagg  gatgacaca  aggagacag  ggattatag  cagttcagg  agtcagtcc  1500
cgcagatca  ggtaaaagt  ttgctactg  atctcaccg  aatactgag  aggaaggac  1560
caagtacaa  tccaaagtt  cactgaaag  caatagaga  agtgatgga  ttagagaag  1620
aaaaaatta  aaacttaaa  agactggat  tgtagtgga  aggcctagc  ctacaaaag  1680
taagcacaa  gaagaagac  aaaattctg  aagaataac  gtaaagaaa  aaactcagt  1740
acctgagca  gtaaagtct  aaaagctca  agacctctt  gattacagt  cccctctac  1800
caagaatct  gatgcacga  aaaagtcta  cttcagaga  gaaagccca  ttaggatca  1860
aatgatagc  agtgattct  accgtcctg  agtcaaact  aaaatggca  ctgttcctc  1920
tgatgattc  aacagacct  cttccttga  taaagacag  ctgcttgct  gtacacttg  1980
ccattctgt  aagaaggag  aagaattcc  atccatctt  gaccacatt  agttgccac  2040
ggccagcaa  agcacttca  agtcattta  tcaacacat  gtgtccttg  ttcatcatg  2100
taaagagca  tacttcaag  cagctgcaa  gaccctaaa  gagcggttc  cttcgtatc  2160
gaaagccac  gaagaacat  gtactcggc  aaagagccc  gaaatacac  ggagaattg  2220
catctcacc  agtaccctg  ggaagcata  ccgtttagc  ggggaagag  gagttttta  2280
agaagaaaa  caaaaggga  ataaaaaat  aaggtgtga  tctgctgac  ttcggcatg  2340
cattgatcg  cgtagaaaa  aaagaagta  agaacgggg  gattccaag  gctccaggg  2400
atccagtgg  tcaagaaag  aggaaaaaa  tccaaaaga  tacaaggaa  acaaatctt  2460
caaagatga  agtaaacat  aaagagagc  agatcattc  cgatcttca  cctcttcag  2520
atcaccttc  tctcccagt  ctcgagaag  aaaggagag  aagaaggaa  gagaagaag  2580
atttaaaac  caccatgaa  tgaaagaat  ctcaggctt  gcaggagtt  gccgaccac  2640
aggaacctt  tttcgaatt  gaggcagag  aagagccag  ggagttttt  ctgggacaa  2700
tactggtcc  aacaactca  atactactt  tcaaaagag  ccgaaggaa  aggaatggg  2760
tccagaata  accccaaag  gcaagaagt  cttcttgca  gacgacaga  atgatggtg  2820
ggattattg  gccaaaaga  gaagaggtc  tggtacttt  caacgtggc  gagggcgct  2880
taacttcaa  aaatcaggt  gcagtccta  atggactca  gacaaatac  aaggggatg  2940
gattgttga  gatgaagaa  agaccatgg  aaataatga  gaaaagaag  acagacgca  3000
ggaagaaaa  gaataataa  tatgaagta  gattacaac  gagcagaac  tgcacccac  3060
atttttttt  cctgatttt  gttttcaaa  aagaatgta  gcattttac  taaatttta  3120
tgtttgcaa  tagtctata  aaattttgt  ttaagtctt  aaatatctt  agaaatagt  3180
gactgtatg  tgaaaattg  actgaaata  agtagaaaa  tgttacgta  catatttgt  3240
actatcaac  tttaaaact  ttaacgttt  tgttacatg  attgtaatt  tgctttgtc  3300
ataagatat  gtcaagtac  gctctgtga  agttctgat  ctcttcctt  cctgtttgt  3360
aatgtttta  tctgaagta  acgttagct  tacatataa  tcctggaac  gaaattgtt  3420
atagagact  cactaatta  tttaactgt  tacatctgt  taatttgaa  acactacat  3480
gtagggtga  tgatttttg  agtatacca  agacaaaaa  ttgttacta  ggtaaacta  3540
gctagttta  cacttgagc  aatgcttaa  aaggaatta  aaaaaaaaa  ctttgccaa  3600
agctaaaaa  tacaagcta  taaaaatca  attgaaaag  tttgagaaa  tgttatttt  3660
actgaaagc  agcagtggc  tataaagaa  attcttagg  gccttttct  tttgcgttc  3720
aaactgtgt  ttctctttc  attcctatt  gatagtttg  gtcatggtc  tagatatta  3780
ctatttgtg  gaggaaact  gtttgtaac  atactgcaa  tagaaaccc  atttctact  3840
aacatccta  ttttaaaca  aagaaaaac  gtaatcctg  ggttggtat  taggaggtc  3900
atcctgcag  ataagttga  acattagta  ctgatttca  atcttacat  tttatttga  3960
ctgaacatt  gtttgtagt  taactatta  taaaaatag  gaaacacag  atactgttc  4020
ttaatagta  tttaaaaaa  ttgtttttc  aatgtcacc  ataaaagtt  tggcaggaa  4080
cttgttgcg  cattgatct  acctttttc  cccccattt  agttgcagt  tttgtagaa  4140
ggctttttc  ttttcctct  aagagttct  ttcttcagg  agataattt  tcaaatgtg  4200
attatcttt  gtgtctata  tgatagctc  taaaggagt  aaaatctaa  atagtaaat  4260
tcaatgtta  gtgtctgct  tatgggcat  tataaaagt  gacacattt  atttgttaa  4320
ttagttgtg  gtgtgtgtt  aaaggagct  atgcttatt  tgttaatgt  aacttttga  4380
gatcttaag  gtattgctc  ttcatctta  acactttcg  ggatttgca  tgcgtctag  4440
acctagatt  cagccagga  cattggtta  gaactgttg  aaacaaaac  aaaagcaaa  4500
tcaacatat  tgatgttta  ggccctcag  tccttagta  tgtgtgatt  tcccccgtt  4560
acatgtctt  ctaaaattg  ctattaaag  agaggaaat  cctgccaaa  gaagtatgt  4620
ttgcattaa  cagggcata  ctaatattc  cctgttcag  ataatactt  tttacgtgt  4680
aaagcaaca  ggatgtgat  cccaacaca  aattttcat  accctttta  tgtatacaa  4740
taaatacca  aacagttac  tggttagac  tcaaatctg  gtgcatgac  atgtgctta  4800
ccacttaag  caataggta  aaggggatc  gagaaatta  gtaataggg  gtgggaata  4860
aactactta  ttcctgtgg  caggttata  tttaagttc  aatgcattg  tttaacctt  4920
ggttacttt  attctgtta  acagaattg  agaaagagt  ttataccag  gtgtagtag  4980
ctagggtga  tgtaagaac  ctgtaatag  atgtcattg  ggatgttac  tttttcaga  5040
ccaagcata  aaaaagcct  tatattttt  aaaaacaca  cttaactcc  cgctttacg  5100
tattataaa  gttgaatgg  tcctcttgg  aaggatatt  gcttacaag  gctaggaaa  5160
aactcactg  tacctgcgt  aacatactt  gttttgcct  gagaggggc  ataaaaatg  5220
accaaagga  atttccaga  aggattaag  aagctgttt  agaaggcca  gactcttta  5280
gtgtgtatg  gtacctttc  gcatcctag  aatttttat  ctaaaagca  aatgttttt  5340
ccagttagt  ttcttcaag  aattactat  gttcctttt  tcacaggta  aatcagtgt  5400
gggaattat  atttgagaa  aatattacc  agtaacatt  aatgtagat  gctaaacga  5460
tcttactca  tgtgatgta  aatgatgca  cagggaccc  tgtaaattg  catacgcca  5520
taaaatgtc  caagtaat  5538



<210> 4680
<211> 921
<212> PRT
<213> Homo sapiens
<308> D79986
<400> 4680

Met Gly Arg Ser Asn Ser Arg Ser His Ser Ser Arg Ser Lys Ser Arg 
  1               5                  10                  15
Ser Gln Ser Ser Ser Arg Ser Arg Ser Arg Ser His Ser Arg Lys Lys 
             20                  25                  30
Arg Tyr Ser Ser Arg Ser Arg Ser Arg Thr Tyr Ser Arg Ser Arg Ser 
         35                  40                  45
Arg Asp Arg Met Tyr Ser Arg Asp Tyr Arg Arg Asp Tyr Arg Asn Asn 
     50                  55                  60
Arg Gly Met Arg Arg Pro Tyr Gly Tyr Arg Gly Arg Gly Arg Gly Tyr 
 65                  70                  75                  80
Tyr Gln Gly Gly Gly Gly Arg Tyr His Arg Gly Gly Tyr Arg Pro Val 
                 85                  90                  95
Trp Asn Arg Arg His Ser Arg Ser Pro Arg Arg Gly Arg Ser Arg Ser 
             100                105                110
Arg Ser Pro Lys Arg Arg Ser Val Ser Ser Gln Arg Ser Arg Ser Arg 
         115                120                125
Ser Arg Arg Ser Tyr Arg Ser Ser Arg Ser Pro Arg Ser Ser Ser Ser 
     130                135                140
Arg Ser Ser Ser Pro Tyr Ser Lys Ser Pro Val Ser Lys Arg Arg Gly 
 145                150                155                160
Ser Gln Glu Lys Gln Thr Lys Lys Ala Glu Gly Glu Pro Gln Glu Glu 
                 165                170                175
Ser Pro Leu Lys Ser Lys Ser Gln Glu Glu Pro Lys Asp Thr Phe Glu 
             180                185                190
His Asp Pro Ser Glu Ser Ile Asp Glu Phe Asn Lys Ser Ser Ala Thr 
         195                200                205
Ser Gly Asp Ile Trp Pro Gly Leu Ser Ala Tyr Asp Asn Ser Pro Arg 
     210                215                220
Ser Pro His Ser Pro Ser Pro Ile Ala Thr Pro Pro Ser Gln Ser Ser 
 225                230                235                240
Ser Cys Ser Asp Ala Pro Met Leu Ser Thr Val His Ser Ala Lys Asn 
                 245                250                255
Thr Pro Ser Gln His Ser His Ser Ile Gln His Ser Pro Glu Arg Ser 
             260                265                270
Gly Ser Gly Ser Val Gly Asn Gly Ser Ser Arg Tyr Ser Pro Ser Gln 
         275                280                285
Asn Ser Pro Ile His His Ile Pro Ser Arg Arg Ser Pro Ala Lys Thr 
     290                295                300
Ile Ala Pro Gln Asn Ala Pro Arg Asp Glu Ser Arg Gly Arg Ser Ser 
 305                310                315                320
Phe Tyr Pro Asp Gly Gly Asp Gln Glu Thr Ala Lys Thr Gly Lys Phe 
                 325                330                335
Leu Lys Arg Phe Thr Asp Glu Glu Ser Arg Val Phe Leu Leu Asp Arg 
             340                345                350
Gly Asn Thr Arg Asp Lys Glu Ala Ser Lys Glu Lys Gly Ser Glu Lys 
         355                360                365
Gly Arg Ala Glu Gly Glu Trp Glu Asp Gln Glu Ala Leu Asp Tyr Phe 
     370                375                380
Ser Asp Lys Glu Ser Gly Lys Gln Lys Phe Asn Asp Ser Glu Gly Asp 
 385                390                395                400
Asp Thr Glu Glu Thr Glu Asp Tyr Arg Gln Phe Arg Lys Ser Val Leu 
                 405                410                415
Ala Asp Gln Gly Lys Ser Phe Ala Thr Ala Ser His Arg Asn Thr Glu 
             420                425                430
Glu Glu Gly Leu Lys Tyr Lys Ser Lys Val Ser Leu Lys Gly Asn Arg 
         435                440                445
Glu Ser Asp Gly Phe Arg Glu Glu Lys Asn Tyr Lys Leu Lys Glu Thr 
     450                455                460
Gly Tyr Val Val Glu Arg Pro Ser Thr Thr Lys Asp Lys His Lys Glu 
 465                470                475                480
Glu Asp Lys Asn Ser Glu Arg Ile Thr Val Lys Lys Glu Thr Gln Ser 
                 485                490                495
Pro Glu Gln Val Lys Ser Glu Lys Leu Lys Asp Leu Phe Asp Tyr Ser 
             500                505                510
Pro Pro Leu His Lys Asn Leu Asp Ala Arg Glu Lys Ser Thr Phe Arg 
         515                520                525
Glu Glu Ser Pro Leu Arg Ile Lys Met Ile Ala Ser Asp Ser His Arg 
     530                535                540
Pro Glu Val Lys Leu Lys Met Ala Pro Val Pro Leu Asp Asp Ser Asn 
 545                550                555                560
Arg Pro Ala Ser Leu Thr Lys Asp Arg Leu Leu Ala Ser Thr Leu Val 
                 565                570                575
His Ser Val Lys Lys Glu Gln Glu Phe Arg Ser Ile Phe Asp His Ile 
             580                585                590
Lys Leu Pro Gln Ala Ser Lys Ser Thr Ser Glu Ser Phe Ile Gln His 
         595                600                605
Ile Val Ser Leu Val His His Val Lys Glu Gln Tyr Phe Lys Ser Ala 
     610                615                620
Ala Met Thr Leu Asn Glu Arg Phe Thr Ser Tyr Gln Lys Ala Thr Glu 
 625                630                635                640
Glu His Ser Thr Arg Gln Lys Ser Pro Glu Ile His Arg Arg Ile Asp 
                 645                650                655
Ile Ser Pro Ser Thr Leu Arg Lys His Thr Arg Leu Ala Gly Glu Glu 
             660                665                670
Arg Val Phe Lys Glu Glu Asn Gln Lys Gly Asp Lys Lys Leu Arg Cys 
         675                680                685
Asp Ser Ala Asp Leu Arg His Asp Ile Asp Arg Arg Arg Lys Glu Arg 
     690                695                700
Ser Lys Glu Arg Gly Asp Ser Lys Gly Ser Arg Glu Ser Ser Gly Ser 
 705                710                715                720
Arg Lys Gln Glu Lys Thr Pro Lys Asp Tyr Lys Glu Tyr Lys Ser Tyr 
                 725                730                735
Lys Asp Asp Ser Lys His Lys Arg Glu Gln Asp His Ser Arg Ser Ser 
             740                745                750
Ser Ser Ser Ala Ser Pro Ser Ser Pro Ser Ser Arg Glu Glu Lys Glu 
         755                760                765
Ser Lys Lys Glu Arg Glu Glu Glu Phe Lys Thr His His Glu Met Lys 
     770                775                780
Glu Tyr Ser Gly Phe Ala Gly Val Ser Arg Pro Arg Gly Thr Phe Phe 
 785                790                795                800
Arg Ile Arg Gly Arg Gly Arg Ala Arg Gly Val Phe Ala Gly Thr Asn 
                 805                810                815
Thr Gly Pro Asn Asn Ser Asn Thr Thr Phe Gln Lys Arg Pro Lys Glu 
             820                825                830
Glu Glu Trp Asp Pro Glu Tyr Thr Pro Lys Ser Lys Lys Tyr Phe Leu 
         835                840                845
His Asp Asp Arg Asp Asp Gly Val Asp Tyr Trp Ala Lys Arg Gly Arg 
     850                855                860
Gly Arg Gly Thr Phe Gln Arg Gly Arg Gly Arg Phe Asn Phe Lys Lys 
 865                870                875                880
Ser Gly Ser Ser Pro Lys Trp Thr His Asp Lys Tyr Gln Gly Asp Gly 
                 885                890                895
Ile Val Glu Asp Glu Glu Glu Thr Met Glu Asn Asn Glu Glu Lys Lys 
             900                905                910
Asp Arg Arg Lys Glu Glu Lys Glu Ter 
         915                920



<210> 4681
<211> 452
<212> DNA
<213> Rattus norvegicus
<308> AA800678
<400> 4681

aaaacatga  tacaagaaa  gaatacttc  tttacgtgt  acactgtct  catggacgt  60
ccgtggtca  ggagtagaa  tacaacatg  gtatacagg  aaggagagg  gagaccggt  120
tttggccct  gtggccccc  cacagagac  cagaaagca  cagacacct  tgtgcattc  180
atgggacag  ggacacttg  gtttggagc  gccagagag  cagggagga  gggcaaagc  240
acctctggg  ccctaattt  gtgtggtaa  cccaaagag  tactggtct  cactggtgg  300
ggctggctc  tgtcaggtt  ttcgcagcc  tcagggaca  gctgaggct  ctgagtgcc  360
agtggtttg  cgcatagct  gctgggccc  tgggctcca  ggtgtgaag  gaaaaaagg  420
caaagtggg  gactggctg  tctctaggt  ac  452



<210> 4682
<211> 640
<212> DNA
<213> Rattus norvegicus
<308> AA800680
<400> 4682

cagttgtgg  agccacagt  cgggcgggc  ggtctcacg  gcggcggcg  gagcgcgag  60
ccgcccgcg  ctttcacct  ccggagaaa  catttcaag  ggaggatcc  gtatctcgg  120
attccgaag  ctcccggtg  gagactcaa  tttcaaaat  gactggagc  tgcgccccg  180
ccccaccct  taggcggtc  ggggccgtg  gaaggctct  gggccctgc  gggctcaga  240
gactgccca  gggaggcgc  ctattgcgg  ggctcgaac  aagggggcc  cggacgcgc  300
actttggtc  tggccgtgg  catagagac  tagcccgat  tccacgcgg  ccagcaaac  360
tggcgcaca  cgaggtagt  ggcgggaag  tacagcaga  acgacgcag  tgaggccag  420
gtccggggt  ggggtggct  tcaccggcc  ctggccgcg  acttggcct  ggtgatgag  480
tagagcacg  tgtcctggt  gcccccgaa  gcggcgatg  gcagtgcgc  ccagccgtc  540
cggttggct  ggcggatgt  tgcgccgaa  ttgactagc  gcttcacca  ctccaggtt  600
ccgtcgatg  ctgactggt  tagtgctgt  tggccctccg  640



<210> 4683
<211> 162
<212> PRT
<213> Rattus norvegicus
<308> BAB28231
<400> 4683

Met Ser Gln Ala Glu Leu Ser Thr Cys Ser Ala Pro Gln Thr Gln Arg 
  1               5                  10                  15
Ile Phe Gln Glu Ala Val Arg Lys Gly Asn Thr Gln Glu Leu Gln Ser 
             20                  25                  30
Leu Leu Gln Asn Met Thr Asn Cys Glu Phe Asn Val Asn Ser Phe Gly 
         35                  40                  45
Pro Glu Gly Gln Thr Ala Leu His Gln Ser Val Ile Asp Gly Asn Leu 
     50                  55                  60
Glu Leu Val Lys Leu Leu Val Lys Phe Gly Ala Asp Ile Arg Leu Ala 
 65                  70                  75                  80
Asn Arg Asp Gly Trp Ser Ala Leu His Ile Ala Ala Phe Gly Gly His 
                 85                  90                  95
Gln Asp Ile Val Leu Tyr Leu Ile Thr Lys Ala Lys Tyr Ala Ala Ser 
             100                105                110
Gly Gly Val Ile Ala Thr Arg Thr Pro Ala Pro Gly Pro His Pro Arg 
         115                120                125
Arg Leu Cys Cys Thr Phe Pro Pro Thr Thr Ser Val Cys Ala Arg Phe 
     130                135                140
Ala Gly Pro Arg Gly Asn Arg Ala Lys Ser Leu Arg Pro Arg Pro Arg 
 145                150                155                160
Pro Lys 
                 165



<210> 4684
<211> 501
<212> DNA
<213> Rattus norvegicus
<308> AA800684
<400> 4684

gaacagact  ttattgagc  cctggtgtg  ggtaccacc  aggcacagc  cacagagac  60
ttagattgg  tggcagccc  caaggaggg  cttcctgga  gcccccaga  aggcagtgg  120
agacagaca  atgcagcaa  cacaagcct  ctcctctct  tggtttcag  aaatggaat  180
gaaagagac  ccttaggtg  tctctaaga  ttagactca  atgttccat  ggtataagg  240
acatgtgta  aacccacat  actacggat  tgtgtatga  acaaaaacg  ctatgtatg  300
cacacgcac  ggcttcacg  gccgagtcg  agtccacgt  tgcacaggc  gcatggata  360
ggcacaaga  ctccagagg  ataggggag  atcttggga  cgcaaggcc  caaggctgg  420
gctggtact  gccctctgt  gctgtgaag  agtcatcca  aacgctccg  aggtagtca  480
acgtgggcc  gtcctctgg  c  501



<210> 4685
<211> 2032
<212> DNA
<213> Homo sapiens
<308> M36881
<400> 4685

cgcctggac  atgtgaatg  ggccagagg  ctcccgggc  gggcaggga  catgggctg  60
ggctgcagc  cacacccgg  agatgactg  atggaaaac  tcgatgtgt  tgagaactg  120
cattatccc  tagtccgac  ggatgggaa  ggcaggctg  tcatccgaa  tggctctga  180
gtgcgggac  cactggtta  ctacgaagg  tccaatccg  cggcttccc  actgcaaga  240
aacctggtt  tcgctctgc  cagctatga  ccctctcac  acggagatc  gggctttga  300
aagggggaa  cactccgca  cctggagca  agcggcgag  ggtggaagg  gcagtccct  360
accacgggc  aggaaggct  catcccctt  aattttgtg  ccaaagcga  cagcctgga  420
cccgaaccc  ggttcttca  gaacctgag  cgcaaggac  cggagcggc  gctcctggc  480
cccgggaac  ctcacggct  cttcctcat  cgggagagc  agagcaccg  cgggtcctt  540
tcactgtcg  tccgggact  cgaccaaaa  cagggagag  tggtgaaac  ttacaagat  600
cgtaatctg  acaacggtg  cttctacat  tcccctcga  tcacttttc  cggcctgca  660
gaactggtc  gccattaca  caatgcttc  gatgggctg  gcacacggt  gagccgccc  720
tgccagacc  agaagcccc  gaagccgtg  tgggaggac  agtgggagg  tcccaggga  780
acgctgaag  tggtggagc  gctgggggc  gcacagttc  gggaggtgt  gatggggta  840
tacaacggg  acacgaagg  ggcggtgaa  agcctgaag  agggcagca  gtccccgga  900
gccttcctg  ccgaggcca  cctcatgaa  cagctgcaa  accagcggc  ggttcggct  960
tacgctgtg  tcacccagg  gcccatcta  atcatcact  aatacatgg  gaatgggag  1020
ctagtggat  ttctcaaga  cccttcagg  atcaagttg  ccatcaaca  actcctgga  1080
atggcagcc  aaattgcag  aggcatggc  ttcattgaa  agcggaatt  tattcatcg  1140
gaccttcgg  ctgccaaca  tctggtgtc  gacaccctg  gctgcaaga  tgcagactt  1200
ggcctagca  gcctcattg  ggacaacga  tacacagcc  gggaggggg  caagtttcc  1260
attaagtgg  cagcgccag  agccattaa  tacgggaca  tcaccatca  gtcagatgt  1320
tggtctttt  ggatcctgc  gacggaaat  gtcacccac  gccgcatcc  ttacccagg  1380
atgaccaac  cggaggtga  tcagaacct  gagcgaggc  accgcatgg  gcgccctga  1440
aactgtcca  aggagctgt  ccaactcat  aggctgtgc  ggaaggagc  cccagagga  1500
cggcccacc  ttgactacc  gcgcagtgt  ctggaggac  tcttcacgg  cacagaggg  1560
cagtaccag  ctcagcctt  agaggaggc  ttgagaggc  ctggggttc  ccccctttc  1620
ctccagcct  acttgggga  atggagttc  tgtgccata  tcacatggc  tatgcacat  1680
tggactctg  acatgaatc  cacccacat  tgacacata  gcaccttgt  tctgtacac  1740
tgtcctgta  ttgcgtgga  tctgcacat  tcttgtgca  gtgtagcct  tgcatgtat  1800
tcttggaca  tgtacaagg  acccctttc  ggctctccc  tttcctgag  ccaccagag  1860
gaggggaga  gcctgggat  gacagaagc  tctgcccac  tacttttct  tcctcagat  1920
atccagaag  tcctgaagg  ccaggactt  atctaatac  tctgtgtgc  cctccttgg  1980
gcctggcct  gcacacatc  ggagttcaa  aaatgtctg  tgatgactg  cg  2032



<210> 4686
<211> 508
<212> PRT
<213> Homo sapiens
<308> P06239
<400> 4686

Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn Ile 
  1               5                  10                  15
Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly Lys 
             20                  25                  30
Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu Val 
         35                  40                  45
Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn Leu 
     50                  55                  60
Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu Gly 
 65                  70                  75                  80
Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu Trp 
                 85                  90                  95
Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro Phe 
             100                105                110
Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe Phe 
         115                120                125
Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro Gly 
     130                135                140
Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala Gly 
 145                150                155                160
Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu Val 
                 165                170                175
Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr Ile 
             180                185                190
Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His Tyr 
         195                200                205
Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys Gln 
     210                215                220
Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val Pro 
 225                230                235                240
Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe Gly 
                 245                250                255
Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val Lys 
             260                265                270
Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu Ala 
         275                280                285
Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr Ala 
     290                295                300
Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu Asn 
 305                310                315                320
Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu Thr 
                 325                330                335
Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met Ala 
             340                345                350
Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn 
         355                360                365
Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly Leu 
     370                375                380
Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys 
 385                390                395                400
Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr Phe 
                 405                410                415
Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Ile 
             420                425                430
Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu Val 
         435                440                445
Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn Cys 
     450                455                460
Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg Pro 
 465                470                475                480
Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp Phe 
                 485                490                495
Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
             500                505



<210> 4687
<211> 501
<212> DNA
<213> Rattus norvegicus
<308> AA800684
<400> 4687

gaacagact  ttattgagc  cctggtgtg  ggtaccacc  aggcacagc  cacagagac  60
ttagattgg  tggcagccc  caaggaggg  cttcctgga  gcccccaga  aggcagtgg  120
agacagaca  atgcagcaa  cacaagcct  ctcctctct  tggtttcag  aaatggaat  180
gaaagagac  ccttaggtg  tctctaaga  ttagactca  atgttccat  ggtataagg  240
acatgtgta  aacccacat  actacggat  tgtgtatga  acaaaaacg  ctatgtatg  300
cacacgcac  ggcttcacg  gccgagtcg  agtccacgt  tgcacaggc  gcatggata  360
ggcacaaga  ctccagagg  ataggggag  atcttggga  cgcaaggcc  caaggctgg  420
gctggtact  gccctctgt  gctgtgaag  agtcatcca  aacgctccg  aggtagtca  480
acgtgggcc  gtcctctgg  c  501



<210> 4688
<211> 2032
<212> DNA
<213> Homo sapiens
<308> M36881
<400> 4688

cgcctggac  atgtgaatg  ggccagagg  ctcccgggc  gggcaggga  catgggctg  60
ggctgcagc  cacacccgg  agatgactg  atggaaaac  tcgatgtgt  tgagaactg  120
cattatccc  tagtccgac  ggatgggaa  ggcaggctg  tcatccgaa  tggctctga  180
gtgcgggac  cactggtta  ctacgaagg  tccaatccg  cggcttccc  actgcaaga  240
aacctggtt  tcgctctgc  cagctatga  ccctctcac  acggagatc  gggctttga  300
aagggggaa  cactccgca  cctggagca  agcggcgag  ggtggaagg  gcagtccct  360
accacgggc  aggaaggct  catcccctt  aattttgtg  ccaaagcga  cagcctgga  420
cccgaaccc  ggttcttca  gaacctgag  cgcaaggac  cggagcggc  gctcctggc  480
cccgggaac  ctcacggct  cttcctcat  cgggagagc  agagcaccg  cgggtcctt  540
tcactgtcg  tccgggact  cgaccaaaa  cagggagag  tggtgaaac  ttacaagat  600
cgtaatctg  acaacggtg  cttctacat  tcccctcga  tcacttttc  cggcctgca  660
gaactggtc  gccattaca  caatgcttc  gatgggctg  gcacacggt  gagccgccc  720
tgccagacc  agaagcccc  gaagccgtg  tgggaggac  agtgggagg  tcccaggga  780
acgctgaag  tggtggagc  gctgggggc  gcacagttc  gggaggtgt  gatggggta  840
tacaacggg  acacgaagg  ggcggtgaa  agcctgaag  agggcagca  gtccccgga  900
gccttcctg  ccgaggcca  cctcatgaa  cagctgcaa  accagcggc  ggttcggct  960
tacgctgtg  tcacccagg  gcccatcta  atcatcact  aatacatgg  gaatgggag  1020
ctagtggat  ttctcaaga  cccttcagg  atcaagttg  ccatcaaca  actcctgga  1080
atggcagcc  aaattgcag  aggcatggc  ttcattgaa  agcggaatt  tattcatcg  1140
gaccttcgg  ctgccaaca  tctggtgtc  gacaccctg  gctgcaaga  tgcagactt  1200
ggcctagca  gcctcattg  ggacaacga  tacacagcc  gggaggggg  caagtttcc  1260
attaagtgg  cagcgccag  agccattaa  tacgggaca  tcaccatca  gtcagatgt  1320
tggtctttt  ggatcctgc  gacggaaat  gtcacccac  gccgcatcc  ttacccagg  1380
atgaccaac  cggaggtga  tcagaacct  gagcgaggc  accgcatgg  gcgccctga  1440
aactgtcca  aggagctgt  ccaactcat  aggctgtgc  ggaaggagc  cccagagga  1500
cggcccacc  ttgactacc  gcgcagtgt  ctggaggac  tcttcacgg  cacagaggg  1560
cagtaccag  ctcagcctt  agaggaggc  ttgagaggc  ctggggttc  ccccctttc  1620
ctccagcct  acttgggga  atggagttc  tgtgccata  tcacatggc  tatgcacat  1680
tggactctg  acatgaatc  cacccacat  tgacacata  gcaccttgt  tctgtacac  1740
tgtcctgta  ttgcgtgga  tctgcacat  tcttgtgca  gtgtagcct  tgcatgtat  1800
tcttggaca  tgtacaagg  acccctttc  ggctctccc  tttcctgag  ccaccagag  1860
gaggggaga  gcctgggat  gacagaagc  tctgcccac  tacttttct  tcctcagat  1920
atccagaag  tcctgaagg  ccaggactt  atctaatac  tctgtgtgc  cctccttgg  1980
gcctggcct  gcacacatc  ggagttcaa  aaatgtctg  tgatgactg  cg  2032



<210> 4689
<211> 508
<212> PRT
<213> Homo sapiens
<308> P06239
<400> 4689

Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn Ile 
  1               5                  10                  15
Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly Lys 
             20                  25                  30
Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu Val 
         35                  40                  45
Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn Leu 
     50                  55                  60
Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu Gly 
 65                  70                  75                  80
Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu Trp 
                 85                  90                  95
Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro Phe 
             100                105                110
Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe Phe 
         115                120                125
Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro Gly 
     130                135                140
Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala Gly 
 145                150                155                160
Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu Val 
                 165                170                175
Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr Ile 
             180                185                190
Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His Tyr 
         195                200                205
Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys Gln 
     210                215                220
Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val Pro 
 225                230                235                240
Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe Gly 
                 245                250                255
Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val Lys 
             260                265                270
Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu Ala 
         275                280                285
Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr Ala 
     290                295                300
Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu Asn 
 305                310                315                320
Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu Thr 
                 325                330                335
Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met Ala 
             340                345                350
Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn 
         355                360                365
Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly Leu 
     370                375                380
Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys 
 385                390                395                400
Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr Phe 
                 405                410                415
Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Ile 
             420                425                430
Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu Val 
         435                440                445
Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn Cys 
     450                455                460
Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg Pro 
 465                470                475                480
Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp Phe 
                 485                490                495
Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
             500                505



<210> 4690
<211> 632
<212> DNA
<213> Rattus norvegicus
<308> AA800686
<400> 4690

aataacaag  aacagaaca  cagtccctt  tttgtacaa  aatacctga  agtttacaa  60
taggttcac  agccaaaga  ctatatagc  cagagtgaa  caaagcacg  gggataaag  120
ttttgtcta  caattaaca  cctctgcat  ccctgaaaa  gtttacatg  caggtcatt  180
tccggtcac  gcagtttac  ctatgatat  acaaatcta  gatgagcta  tagcgccct  240
ggaggcaca  tgatcggac  ggctgtcag  tatttaagt  cagaaagga  aagacaaaa  300
atctaagct  aggcacata  ttcttcaaa  tttaagcaa  caaaaaaag  aaaaagaaa  360
cacgtttgg  aactcttaa  acctaataa  ataacagag  ctacgtatt  aaacgctaa  420
aacccaaag  atttggcat  ttccttctc  acttagtcc  ggtggttac  cggagttgt  480
cttaagaaa  gaaaatcac  ggcagagat  gcaaagtca  acaggctcc  aacaaccct  540
agctgtccc  ttacattca  gtcaattaa  tacaanaat  aaagtcaat  gtccttcag  600
ctccggtta  gggcggctg  gtgcccgct  ac  632



<210> 4691
<211> 5431
<212> DNA
<213> Homo sapiens
<308> D86962
<400> 4691

ggcagccgg  cgccccgcg  ggctctccg  gctgcgttc  cgacccctg  ggggaggtg  60
ggagtccaa  cggtgcatt  ttgaaccat  ttgtcagac  ccggcggct  gcgggctgt  120
gcgggggct  cggtcaagg  cgcgctcct  ggggccgcc  cctgggagg  tgggcgccc  180
ggcgtccct  cagccccgg  tgctccgac  gcgcggcgg  gccgcggcg  gcgcgcccg  240
gcgtccggg  gtccgggac  gtggtgcca  acactccca  atcccgagc  ggcccagcc  300
cgtacggag  acctttttt  tggttctgt  ggtgacccg  tagccgccg  tggggccta  360
caccaagtt  agggctcgc  gattagccg  ccgccagcc  tggaaatgt  ataagagcg  420
taccgtttg  agaaggaaa  ttctgatgc  actcttcgc  tttgctgat  gcctctcca  480
acgcctgcc  gacgactgc  ttggagcat  tgcgttatg  aaattaggc  ttggcgctg  540
ccacaatgc  gagcaggaa  cagcagctg  aggcccagt  actggtagc  cagtgacca  600
cagcccagt  accggcagc  aggtcctca  ctgggtcct  tcagtgaag  cagggtggc  660
gccccagca  acagtgcta  agagccaac  cctgacagg  tctgaaaat  ttgtgcaca  720
ggcaggctg  ggacacagc  acgtgatac  cactgtaga  agagggaga  agagacctc  780
tatgcaagc  gccggccct  tgttccgta  taaggacaa  gtggagcag  cacctcgca  840
tcaacaaga  ccggcagga  caggactcc  cgcacagtc  gaccgactt  cgaatcacc  900
ggaggatga  gtggacctg  aagccctgg  gaacgatat  aatgcatcc  tggagagcc  960
gtactcggc  tgcagcatg  agtcagaca  ggtgcccct  ctgcagaat  gccagcatg  1020
ccgcagcca  cctcgggct  caggccctc  tcggtccat  cagccacag  tgtccccga  1080
gcagagggt  cagcgctcc  agcctgtgc  catcctcgc  gtcaggcgc  ttcaggagg  1140
agaccagca  tttagaacc  catctctgc  ggccatccc  aatcctttt  ctgaactct  1200
tggccctgg  agccccgct  tgctcacgc  gggttcttt  cctccgagc  aggccgccg  1260
aaagcagga  gttaaagtc  ttagtgaag  tgggacaag  aaagtggtg  agattctag  1320
agacatgac  gccagagac  tgtgccaat  gctggttta  aaaagtcac  gtgtggatg  1380
caacagctg  acactagtg  agcaccacc  gcacctagg  ttagagagg  gcttggaag  1440
ccatgagct  gtggtccag  tggagagta  catggccag  gagagtaaa  ttctattca  1500
gaagaatta  gcaaaatac  agttcttta  aaatcccat  aatttcttc  cagaacaga  1560
ggttacttg  tgccagcag  caaatggca  tcaaaccca  cttttgcag  attttctga  1620
ctccagtag  tgtcctgaa  ttcaagggt  tttgcatgt  aaagagctg  gaaagaaat  1680
atggaaaaa  ctgtatgtg  gtttgcgga  atctggcct  tattgctcc  ccaagggaa  1740
ttcaaagga  cccagacac  tgcagctgc  ggccgacct  gaggacagc  acatcttct  1800
cctgatcgc  ggcaggaag  agtacaacg  ccctacaga  cacgggctc  gcataaagc  1860
aaacaaagt  aggaatgaa  ctaaagagc  gaggttgct  tgtgcagag  acgagcaaa  1920
caggacgtg  tggatgaca  cgttcagac  cctcaagta  ggaatgctc  tttaccaga  1980
ttaccgaat  cctcagcag  ggaaggcct  gctgtcccc  ttctcgacg  cagtgcgca  2040
tgtctccga  aactccctc  tggcaatgg  tttttctgg  caaacagga  gcgtgatag  2100
gaatccggc  gaggcccag  gcgcagccc  ggaggaggg  cacgcctgg  ggaagcgaa  2160
cacacggat  aacatccta  gtagccaaa  tcccctcca  ccttctacc  taagtacag  2220
gattcacag  acacagcac  ggtttcacg  gaggatctc  agggaggaa  cccacagga  2280
cattaaaca  caagggctc  tggatgggc  ttttctcct  cgtgacagc  agagtaatc  2340
aaaggcatt  gtactcaca  tgtgtcatc  ccagaaaat  aaaaatttc  agatcttac  2400
ttgcgagga  gacgggcag  cgttcttca  cctagatga  gggaacacc  aattctctg  2460
cctgatcca  ctggttgac  tttaccagc  gaacaaagg  gtcctgcct  gcaaactca  2520
gcaccactg  atccgagtg  ccttatgac  gcagatgtc  tctcggctg  agactggag  2580
aagtgaaca  tggagtgaa  aagcggtct  tgcgttggt  aagaacaca  atcgattct  2640
cacctgggg  cccagagcg  gatgggttt  ttcggtgcc  gccgaccaa  attgactag  2700
ttgttggac  taaacgacg  tttgctgct  tgaacccag  agggtcgcc  ccctctgcg  2760
cagccaaat  ggggagggc  tggaagatc  agcggaaag  tgaaaataa  ctggaatga  2820
catcttggc  tgggccgct  aggaacaag  accggagag  agtgattgg  aatgaactc  2880
tgccctgga  taatcttga  aattaaaac  gatatgttt  ctttttttg  attgatcac  2940
tttttgcac  ccttctttg  tttcaatat  gtattcagc  tattgtagg  gggggatgt  3000
gcgtttcaa  tcatataat  cagaaagag  tttgaatgg  cagatttca  actgaatat  3060
ggtccccaa  tgttcccag  gggtcctcc  caccctctg  cgactacca  ggtgtggat  3120
cagctccca  atgacaaac  cagcccttc  cagtatact  gaaaagctt  cttgttaaa  3180
taaaaggtg  cactgtggt  ggcatttgg  atattttgt  gactcagtc  agcaaccac  3240
gtctgttaa  catttctct  tgctcagat  tcagatcct  ttgttatta  tgtgtcttg  3300
tctgcacag  gcaggagac  ttattcctt  ggaaaattc  ctgttccac  aacagcagg  3360
tgaatggcc  cgcctctag  ttgacgtgg  ccagcctcc  tgagacaca  ctggcaccc  3420
tcatcggcc  gcggtggat  ctgcataat  cacctgggt  cttcagcct  gcgtttcca  3480
agccttcag  ctgttctag  acgatcact  ccttacccc  gctgctgca  tggtgtgag  3540
cgtttcacg  ctgatgtcc  tcgggggat  aaaggatct  aagagaaaa  ggcacctgg  3600
tgtcttcgt  ctgtgtctc  tgggtttcc  tagtgataa  gacaaggaa  cgctgcagg  3660
gccacaggc  caggctgat  tttaaagat  tttgcttgc  gccctccgt  ctgctgaaa  3720
cccccataa  ccagtgaac  cagagcagc  agaggctcc  cctctgctg  cttagggtc  3780
gaagtacct  acagtggtt  tggacatgg  agagttttg  caacacaac  ctttgtccc  3840
gctccggga  atgagtcag  tggtggctt  agttgtcac  tggtcccct  cgcccctcg  3900
gtggccccc  ttgccacgt  cccttagct  agtgatcag  tgtgagagt  gccatttcc  3960
tacctttga  ccctgtaaa  cagaaagga  tcctttgac  ggcgacaaa  tactgtggt  4020
agcagaatg  tttcctttt  caagacaac  cctgcctgg  ttctattaa  gtgtgctgg  4080
catgatatt  ccccaaatc  gccccactg  agtgttccc  aaggaacag  atttctctg  4140
tcctcagtc  acccccgta  cctagagca  tgtcacaag  ttcagtaag  ccagtcagc  4200
ggaagtcag  ctaccgtat  gtaacactg  atttcagtc  acagaccac  ctctagttg  4260
tttccatga  aggtataca  atgaagaat  ttctagcaa  acatgtttt  aaccatcag  4320
gctcaattg  attttcttc  tttcgcagc  agtcagtct  tcaaactat  gacagtaag  4380
taattctca  gttcacacc  ggtggcagg  ttcactgta  ggacggaca  tgcagttac  4440
ccacgattc  ttcctcttc  ctggctcga  gtaaaccct  ttcaaggaa  aacaactct  4500
ggatttctt  tttctgtgt  cgtagacca  tcccatcag  gtataatct  tctctcaca  4560
gcctctctc  aatagacag  ttgtatttg  agtatttca  atttataaa  atgcgttta  4620
ttaaaagga  aacaaaagc  tgactctga  tcacagttt  gtatgtagc  ggtttgacg  4680
agtcttttg  attttccct  ccgaagtga  ttgttggag  atgtaaacc  cctccacgt  4740
gcggcagac  tcctaaggc  ccagctcgc  ggcctcgcg  tgggcggct  ggaattcca  4800
ctgagaaca  gtcccgcaa  ccggggacg  aaggacatt  gacttttat  tttgtattt  4860
attgacatg  atgtaaagg  gacagctca  ggttgtttt  gagcctgtt  actttgtat  4920
tctgcctgt  attttcttt  ctaaatgaa  ctccatgta  caaccagga  gaagttgag  4980
aggaaaacg  caaatgctt  ggttattag  gtttaatag  taagctctg  tacactagg  5040
gttagagtt  cagaatgtt  ttttgtttg  taaaccttg  agaaacatg  gcctcagcc  5100
agatgtttt  tcttctctt  tctgcactt  atacctgac  gtatgaccg  tctctgcgc  5160
tttctgggg  cgggcaagc  ggcggtaga  ttgtgatgt  acagtgcaa  ctgcagtga  5220
tgtaaattg  cctggcgtg  ataaacgtt  tcagggaat  cagaaggta  taatgaaga  5280
acaaaacct  tattccatg  gctttgctt  attctgtac  tagctcttt  gctcgtgaa  5340
ctaattgta  actttcagg  atttttgta  aaataaggg  ctgatgttc  gtttcttgt  5400
attagaaat  aacattaat  cagtgttct  c  5431



<210> 4692
<211> 594
<212> PRT
<213> Homo sapiens
<308> Q13322
<400> 4692

Met Ala Leu Ala Gly Cys Pro Asp Ser Phe Leu His His Pro Tyr Tyr 
  1               5                  10                  15
Gln Asp Lys Val Glu Gln Thr Pro Arg Ser Gln Gln Asp Pro Ala Gly 
             20                  25                  30
Pro Gly Leu Pro Ala Gln Ser Asp Arg Leu Ala Asn His Gln Glu Asp 
         35                  40                  45
Asp Val Asp Leu Glu Ala Leu Val Asn Asp Met Asn Ala Ser Leu Glu 
     50                  55                  60
Ser Leu Tyr Ser Ala Cys Ser Met Gln Ser Asp Thr Val Pro Leu Leu 
 65                  70                  75                  80
Gln Asn Gly Gln His Ala Arg Ser Gln Pro Arg Ala Ser Gly Pro Pro 
                 85                  90                  95
Arg Ser Ile Gln Pro Gln Val Ser Pro Arg Gln Arg Val Gln Arg Ser 
             100                105                110
Gln Pro Val His Ile Leu Ala Val Arg Arg Leu Gln Glu Glu Asp Gln 
         115                120                125
Gln Phe Arg Thr Ser Ser Leu Pro Ala Ile Pro Asn Pro Phe Pro Glu 
     130                135                140
Leu Cys Gly Pro Gly Ser Pro Pro Val Leu Thr Pro Gly Ser Leu Pro 
 145                150                155                160
Pro Ser Gln Ala Ala Ala Lys Gln Asp Val Lys Val Phe Ser Glu Asp 
                 165                170                175
Gly Thr Ser Lys Val Val Glu Ile Leu Ala Asp Met Thr Ala Arg Asp 
             180                185                190
Leu Cys Gln Leu Leu Val Tyr Lys Ser His Cys Val Asp Asp Asn Ser 
         195                200                205
Trp Thr Leu Val Glu His His Pro His Leu Gly Leu Glu Arg Cys Leu 
     210                215                220
Glu Asp His Glu Leu Val Val Gln Val Glu Ser Thr Met Ala Ser Glu 
 225                230                235                240
Ser Lys Phe Leu Phe Arg Lys Asn Tyr Ala Lys Tyr Glu Phe Phe Lys 
                 245                250                255
Asn Pro Met Asn Phe Phe Pro Glu Gln Met Val Thr Trp Cys Gln Gln 
             260                265                270
Ser Asn Gly Ser Gln Thr Gln Leu Leu Gln Asn Phe Leu Asn Ser Ser 
         275                280                285
Ser Cys Pro Glu Ile Gln Gly Phe Leu His Val Lys Glu Leu Gly Lys 
     290                295                300
Lys Ser Trp Lys Lys Leu Tyr Val Cys Leu Arg Arg Ser Gly Leu Tyr 
 305                310                315                320
Cys Ser Thr Lys Gly Thr Ser Lys Glu Pro Arg His Leu Gln Leu Leu 
                 325                330                335
Ala Asp Leu Glu Asp Ser Asn Ile Phe Ser Leu Ile Ala Gly Arg Lys 
             340                345                350
Gln Tyr Asn Ala Pro Thr Asp His Gly Leu Cys Ile Lys Pro Asn Lys 
         355                360                365
Val Arg Asn Glu Thr Lys Glu Leu Arg Leu Leu Cys Ala Glu Asp Glu 
     370                375                380
Gln Thr Arg Thr Cys Trp Met Thr Ala Phe Arg Leu Leu Lys Tyr Gly 
 385                390                395                400
Met Leu Leu Tyr Gln Asn Tyr Arg Ile Pro Gln Gln Arg Lys Ala Leu 
                 405                410                415
Leu Ser Pro Phe Ser Thr Pro Val Arg Ser Val Ser Glu Asn Ser Leu 
             420                425                430
Val Ala Met Asp Phe Ser Gly Gln Thr Gly Arg Val Ile Glu Asn Pro 
         435                440                445
Ala Glu Ala Gln Ser Ala Ala Leu Glu Glu Gly His Ala Trp Arg Lys 
     450                455                460
Arg Ser Thr Arg Met Asn Ile Leu Gly Ser Gln Ser Pro Leu His Pro 
 465                470                475                480
Ser Thr Leu Ser Thr Val Ile His Arg Thr Gln His Trp Phe His Gly 
                 485                490                495
Arg Ile Ser Arg Glu Glu Ser His Arg Ile Ile Lys Gln Gln Gly Leu 
             500                505                510
Val Asp Gly Leu Phe Leu Leu Arg Asp Ser Gln Ser Asn Pro Lys Ala 
         515                520                525
Phe Val Leu Thr Leu Cys His His Gln Lys Ile Lys Asn Phe Gln Ile 
     530                535                540
Leu Pro Cys Glu Asp Asp Gly Gln Thr Phe Phe Ser Leu Asp Asp Gly 
 545                550                555                560
Asn Thr Lys Phe Ser Asp Leu Ile Gln Leu Val Asp Phe Tyr Gln Leu 
                 565                570                575
Asn Lys Gly Val Leu Pro Cys Lys Leu Lys His His Cys Ile Arg Val 
             580                585                590
Ala Leu 
         595



<210> 4693
<211> 632
<212> DNA
<213> Rattus norvegicus
<308> AA800686
<400> 4693

aataacaag  aacagaaca  cagtccctt  tttgtacaa  aatacctga  agtttacaa  60
taggttcac  agccaaaga  ctatatagc  cagagtgaa  caaagcacg  gggataaag  120
ttttgtcta  caattaaca  cctctgcat  ccctgaaaa  gtttacatg  caggtcatt  180
tccggtcac  gcagtttac  ctatgatat  acaaatcta  gatgagcta  tagcgccct  240
ggaggcaca  tgatcggac  ggctgtcag  tatttaagt  cagaaagga  aagacaaaa  300
atctaagct  aggcacata  ttcttcaaa  tttaagcaa  caaaaaaag  aaaaagaaa  360
cacgtttgg  aactcttaa  acctaataa  ataacagag  ctacgtatt  aaacgctaa  420
aacccaaag  atttggcat  ttccttctc  acttagtcc  ggtggttac  cggagttgt  480
cttaagaaa  gaaaatcac  ggcagagat  gcaaagtca  acaggctcc  aacaaccct  540
agctgtccc  ttacattca  gtcaattaa  tacaanaat  aaagtcaat  gtccttcag  600
ctccggtta  gggcggctg  gtgcccgct  ac  632



<210> 4694
<211> 5431
<212> DNA
<213> Homo sapiens
<308> D86962
<400> 4694

ggcagccgg  cgccccgcg  ggctctccg  gctgcgttc  cgacccctg  ggggaggtg  60
ggagtccaa  cggtgcatt  ttgaaccat  ttgtcagac  ccggcggct  gcgggctgt  120
gcgggggct  cggtcaagg  cgcgctcct  ggggccgcc  cctgggagg  tgggcgccc  180
ggcgtccct  cagccccgg  tgctccgac  gcgcggcgg  gccgcggcg  gcgcgcccg  240
gcgtccggg  gtccgggac  gtggtgcca  acactccca  atcccgagc  ggcccagcc  300
cgtacggag  acctttttt  tggttctgt  ggtgacccg  tagccgccg  tggggccta  360
caccaagtt  agggctcgc  gattagccg  ccgccagcc  tggaaatgt  ataagagcg  420
taccgtttg  agaaggaaa  ttctgatgc  actcttcgc  tttgctgat  gcctctcca  480
acgcctgcc  gacgactgc  ttggagcat  tgcgttatg  aaattaggc  ttggcgctg  540
ccacaatgc  gagcaggaa  cagcagctg  aggcccagt  actggtagc  cagtgacca  600
cagcccagt  accggcagc  aggtcctca  ctgggtcct  tcagtgaag  cagggtggc  660
gccccagca  acagtgcta  agagccaac  cctgacagg  tctgaaaat  ttgtgcaca  720
ggcaggctg  ggacacagc  acgtgatac  cactgtaga  agagggaga  agagacctc  780
tatgcaagc  gccggccct  tgttccgta  taaggacaa  gtggagcag  cacctcgca  840
tcaacaaga  ccggcagga  caggactcc  cgcacagtc  gaccgactt  cgaatcacc  900
ggaggatga  gtggacctg  aagccctgg  gaacgatat  aatgcatcc  tggagagcc  960
gtactcggc  tgcagcatg  agtcagaca  ggtgcccct  ctgcagaat  gccagcatg  1020
ccgcagcca  cctcgggct  caggccctc  tcggtccat  cagccacag  tgtccccga  1080
gcagagggt  cagcgctcc  agcctgtgc  catcctcgc  gtcaggcgc  ttcaggagg  1140
agaccagca  tttagaacc  catctctgc  ggccatccc  aatcctttt  ctgaactct  1200
tggccctgg  agccccgct  tgctcacgc  gggttcttt  cctccgagc  aggccgccg  1260
aaagcagga  gttaaagtc  ttagtgaag  tgggacaag  aaagtggtg  agattctag  1320
agacatgac  gccagagac  tgtgccaat  gctggttta  aaaagtcac  gtgtggatg  1380
caacagctg  acactagtg  agcaccacc  gcacctagg  ttagagagg  gcttggaag  1440
ccatgagct  gtggtccag  tggagagta  catggccag  gagagtaaa  ttctattca  1500
gaagaatta  gcaaaatac  agttcttta  aaatcccat  aatttcttc  cagaacaga  1560
ggttacttg  tgccagcag  caaatggca  tcaaaccca  cttttgcag  attttctga  1620
ctccagtag  tgtcctgaa  ttcaagggt  tttgcatgt  aaagagctg  gaaagaaat  1680
atggaaaaa  ctgtatgtg  gtttgcgga  atctggcct  tattgctcc  ccaagggaa  1740
ttcaaagga  cccagacac  tgcagctgc  ggccgacct  gaggacagc  acatcttct  1800
cctgatcgc  ggcaggaag  agtacaacg  ccctacaga  cacgggctc  gcataaagc  1860
aaacaaagt  aggaatgaa  ctaaagagc  gaggttgct  tgtgcagag  acgagcaaa  1920
caggacgtg  tggatgaca  cgttcagac  cctcaagta  ggaatgctc  tttaccaga  1980
ttaccgaat  cctcagcag  ggaaggcct  gctgtcccc  ttctcgacg  cagtgcgca  2040
tgtctccga  aactccctc  tggcaatgg  tttttctgg  caaacagga  gcgtgatag  2100
gaatccggc  gaggcccag  gcgcagccc  ggaggaggg  cacgcctgg  ggaagcgaa  2160
cacacggat  aacatccta  gtagccaaa  tcccctcca  ccttctacc  taagtacag  2220
gattcacag  acacagcac  ggtttcacg  gaggatctc  agggaggaa  cccacagga  2280
cattaaaca  caagggctc  tggatgggc  ttttctcct  cgtgacagc  agagtaatc  2340
aaaggcatt  gtactcaca  tgtgtcatc  ccagaaaat  aaaaatttc  agatcttac  2400
ttgcgagga  gacgggcag  cgttcttca  cctagatga  gggaacacc  aattctctg  2460
cctgatcca  ctggttgac  tttaccagc  gaacaaagg  gtcctgcct  gcaaactca  2520
gcaccactg  atccgagtg  ccttatgac  gcagatgtc  tctcggctg  agactggag  2580
aagtgaaca  tggagtgaa  aagcggtct  tgcgttggt  aagaacaca  atcgattct  2640
cacctgggg  cccagagcg  gatgggttt  ttcggtgcc  gccgaccaa  attgactag  2700
ttgttggac  taaacgacg  tttgctgct  tgaacccag  agggtcgcc  ccctctgcg  2760
cagccaaat  ggggagggc  tggaagatc  agcggaaag  tgaaaataa  ctggaatga  2820
catcttggc  tgggccgct  aggaacaag  accggagag  agtgattgg  aatgaactc  2880
tgccctgga  taatcttga  aattaaaac  gatatgttt  ctttttttg  attgatcac  2940
tttttgcac  ccttctttg  tttcaatat  gtattcagc  tattgtagg  gggggatgt  3000
gcgtttcaa  tcatataat  cagaaagag  tttgaatgg  cagatttca  actgaatat  3060
ggtccccaa  tgttcccag  gggtcctcc  caccctctg  cgactacca  ggtgtggat  3120
cagctccca  atgacaaac  cagcccttc  cagtatact  gaaaagctt  cttgttaaa  3180
taaaaggtg  cactgtggt  ggcatttgg  atattttgt  gactcagtc  agcaaccac  3240
gtctgttaa  catttctct  tgctcagat  tcagatcct  ttgttatta  tgtgtcttg  3300
tctgcacag  gcaggagac  ttattcctt  ggaaaattc  ctgttccac  aacagcagg  3360
tgaatggcc  cgcctctag  ttgacgtgg  ccagcctcc  tgagacaca  ctggcaccc  3420
tcatcggcc  gcggtggat  ctgcataat  cacctgggt  cttcagcct  gcgtttcca  3480
agccttcag  ctgttctag  acgatcact  ccttacccc  gctgctgca  tggtgtgag  3540
cgtttcacg  ctgatgtcc  tcgggggat  aaaggatct  aagagaaaa  ggcacctgg  3600
tgtcttcgt  ctgtgtctc  tgggtttcc  tagtgataa  gacaaggaa  cgctgcagg  3660
gccacaggc  caggctgat  tttaaagat  tttgcttgc  gccctccgt  ctgctgaaa  3720
cccccataa  ccagtgaac  cagagcagc  agaggctcc  cctctgctg  cttagggtc  3780
gaagtacct  acagtggtt  tggacatgg  agagttttg  caacacaac  ctttgtccc  3840
gctccggga  atgagtcag  tggtggctt  agttgtcac  tggtcccct  cgcccctcg  3900
gtggccccc  ttgccacgt  cccttagct  agtgatcag  tgtgagagt  gccatttcc  3960
tacctttga  ccctgtaaa  cagaaagga  tcctttgac  ggcgacaaa  tactgtggt  4020
agcagaatg  tttcctttt  caagacaac  cctgcctgg  ttctattaa  gtgtgctgg  4080
catgatatt  ccccaaatc  gccccactg  agtgttccc  aaggaacag  atttctctg  4140
tcctcagtc  acccccgta  cctagagca  tgtcacaag  ttcagtaag  ccagtcagc  4200
ggaagtcag  ctaccgtat  gtaacactg  atttcagtc  acagaccac  ctctagttg  4260
tttccatga  aggtataca  atgaagaat  ttctagcaa  acatgtttt  aaccatcag  4320
gctcaattg  attttcttc  tttcgcagc  agtcagtct  tcaaactat  gacagtaag  4380
taattctca  gttcacacc  ggtggcagg  ttcactgta  ggacggaca  tgcagttac  4440
ccacgattc  ttcctcttc  ctggctcga  gtaaaccct  ttcaaggaa  aacaactct  4500
ggatttctt  tttctgtgt  cgtagacca  tcccatcag  gtataatct  tctctcaca  4560
gcctctctc  aatagacag  ttgtatttg  agtatttca  atttataaa  atgcgttta  4620
ttaaaagga  aacaaaagc  tgactctga  tcacagttt  gtatgtagc  ggtttgacg  4680
agtcttttg  attttccct  ccgaagtga  ttgttggag  atgtaaacc  cctccacgt  4740
gcggcagac  tcctaaggc  ccagctcgc  ggcctcgcg  tgggcggct  ggaattcca  4800
ctgagaaca  gtcccgcaa  ccggggacg  aaggacatt  gacttttat  tttgtattt  4860
attgacatg  atgtaaagg  gacagctca  ggttgtttt  gagcctgtt  actttgtat  4920
tctgcctgt  attttcttt  ctaaatgaa  ctccatgta  caaccagga  gaagttgag  4980
aggaaaacg  caaatgctt  ggttattag  gtttaatag  taagctctg  tacactagg  5040
gttagagtt  cagaatgtt  ttttgtttg  taaaccttg  agaaacatg  gcctcagcc  5100
agatgtttt  tcttctctt  tctgcactt  atacctgac  gtatgaccg  tctctgcgc  5160
tttctgggg  cgggcaagc  ggcggtaga  ttgtgatgt  acagtgcaa  ctgcagtga  5220
tgtaaattg  cctggcgtg  ataaacgtt  tcagggaat  cagaaggta  taatgaaga  5280
acaaaacct  tattccatg  gctttgctt  attctgtac  tagctcttt  gctcgtgaa  5340
ctaattgta  actttcagg  atttttgta  aaataaggg  ctgatgttc  gtttcttgt  5400
attagaaat  aacattaat  cagtgttct  c  5431



<210> 4695
<211> 594
<212> PRT
<213> Homo sapiens
<308> Q13322
<400> 4695

Met Ala Leu Ala Gly Cys Pro Asp Ser Phe Leu His His Pro Tyr Tyr 
  1               5                  10                  15
Gln Asp Lys Val Glu Gln Thr Pro Arg Ser Gln Gln Asp Pro Ala Gly 
             20                  25                  30
Pro Gly Leu Pro Ala Gln Ser Asp Arg Leu Ala Asn His Gln Glu Asp 
         35                  40                  45
Asp Val Asp Leu Glu Ala Leu Val Asn Asp Met Asn Ala Ser Leu Glu 
     50                  55                  60
Ser Leu Tyr Ser Ala Cys Ser Met Gln Ser Asp Thr Val Pro Leu Leu 
 65                  70                  75                  80
Gln Asn Gly Gln His Ala Arg Ser Gln Pro Arg Ala Ser Gly Pro Pro 
                 85                  90                  95
Arg Ser Ile Gln Pro Gln Val Ser Pro Arg Gln Arg Val Gln Arg Ser 
             100                105                110
Gln Pro Val His Ile Leu Ala Val Arg Arg Leu Gln Glu Glu Asp Gln 
         115                120                125
Gln Phe Arg Thr Ser Ser Leu Pro Ala Ile Pro Asn Pro Phe Pro Glu 
     130                135                140
Leu Cys Gly Pro Gly Ser Pro Pro Val Leu Thr Pro Gly Ser Leu Pro 
 145                150                155                160
Pro Ser Gln Ala Ala Ala Lys Gln Asp Val Lys Val Phe Ser Glu Asp 
                 165                170                175
Gly Thr Ser Lys Val Val Glu Ile Leu Ala Asp Met Thr Ala Arg Asp 
             180                185                190
Leu Cys Gln Leu Leu Val Tyr Lys Ser His Cys Val Asp Asp Asn Ser 
         195                200                205
Trp Thr Leu Val Glu His His Pro His Leu Gly Leu Glu Arg Cys Leu 
     210                215                220
Glu Asp His Glu Leu Val Val Gln Val Glu Ser Thr Met Ala Ser Glu 
 225                230                235                240
Ser Lys Phe Leu Phe Arg Lys Asn Tyr Ala Lys Tyr Glu Phe Phe Lys 
                 245                250                255
Asn Pro Met Asn Phe Phe Pro Glu Gln Met Val Thr Trp Cys Gln Gln 
             260                265                270
Ser Asn Gly Ser Gln Thr Gln Leu Leu Gln Asn Phe Leu Asn Ser Ser 
         275                280                285
Ser Cys Pro Glu Ile Gln Gly Phe Leu His Val Lys Glu Leu Gly Lys 
     290                295                300
Lys Ser Trp Lys Lys Leu Tyr Val Cys Leu Arg Arg Ser Gly Leu Tyr 
 305                310                315                320
Cys Ser Thr Lys Gly Thr Ser Lys Glu Pro Arg His Leu Gln Leu Leu 
                 325                330                335
Ala Asp Leu Glu Asp Ser Asn Ile Phe Ser Leu Ile Ala Gly Arg Lys 
             340                345                350
Gln Tyr Asn Ala Pro Thr Asp His Gly Leu Cys Ile Lys Pro Asn Lys 
         355                360                365
Val Arg Asn Glu Thr Lys Glu Leu Arg Leu Leu Cys Ala Glu Asp Glu 
     370                375                380
Gln Thr Arg Thr Cys Trp Met Thr Ala Phe Arg Leu Leu Lys Tyr Gly 
 385                390                395                400
Met Leu Leu Tyr Gln Asn Tyr Arg Ile Pro Gln Gln Arg Lys Ala Leu 
                 405                410                415
Leu Ser Pro Phe Ser Thr Pro Val Arg Ser Val Ser Glu Asn Ser Leu 
             420                425                430
Val Ala Met Asp Phe Ser Gly Gln Thr Gly Arg Val Ile Glu Asn Pro 
         435                440                445
Ala Glu Ala Gln Ser Ala Ala Leu Glu Glu Gly His Ala Trp Arg Lys 
     450                455                460
Arg Ser Thr Arg Met Asn Ile Leu Gly Ser Gln Ser Pro Leu His Pro 
 465                470                475                480
Ser Thr Leu Ser Thr Val Ile His Arg Thr Gln His Trp Phe His Gly 
                 485                490                495
Arg Ile Ser Arg Glu Glu Ser His Arg Ile Ile Lys Gln Gln Gly Leu 
             500                505                510
Val Asp Gly Leu Phe Leu Leu Arg Asp Ser Gln Ser Asn Pro Lys Ala 
         515                520                525
Phe Val Leu Thr Leu Cys His His Gln Lys Ile Lys Asn Phe Gln Ile 
     530                535                540
Leu Pro Cys Glu Asp Asp Gly Gln Thr Phe Phe Ser Leu Asp Asp Gly 
 545                550                555                560
Asn Thr Lys Phe Ser Asp Leu Ile Gln Leu Val Asp Phe Tyr Gln Leu 
                 565                570                575
Asn Lys Gly Val Leu Pro Cys Lys Leu Lys His His Cys Ile Arg Val 
             580                585                590
Ala Leu 
         595



<210> 4696
<211> 533
<212> DNA
<213> Rattus norvegicus
<308> AA800693
<400> 4696

tatttgtgg  tagtcatag  agtcaacag  ccagcacag  acagacaca  ctacacagt  60
ctcatgtcc  caaacacac  gacagggga  agcacacag  gctgggaga  ttgggctaa  120
accacctaa  tccagagca  gcccctcct  cacagcagg  attgtgggg  caactgtgc  180
ttgctctaa  gaccagggg  ctctgggga  gtgaggtct  tgggaagga  tagcagggt  240
gggccagcc  cacagtgca  cccatttga  aattggtcc  ggtttgcaa  acatgggtg  300
gattctgac  tgctcagtg  caggaatgg  cagctataa  ccagagcat  cacgagtaa  360
aggtttcat  cttcgaggg  tttgttcat  aagagttca  ctccatgca  aatacactg  420
catcatacc  ccatcatcc  aaaaaaagg  gttgggtgt  ttgtgggaa  cactcaggc  480
tgagctttg  gaggacatt  cttctgcct  cctgctctg  gagttatga  gga  533



<210> 4697
<211> 533
<212> DNA
<213> Rattus norvegicus
<308> AA800693
<400> 4697

tatttgtgg  tagtcatag  agtcaacag  ccagcacag  acagacaca  ctacacagt  60
ctcatgtcc  caaacacac  gacagggga  agcacacag  gctgggaga  ttgggctaa  120
accacctaa  tccagagca  gcccctcct  cacagcagg  attgtgggg  caactgtgc  180
ttgctctaa  gaccagggg  ctctgggga  gtgaggtct  tgggaagga  tagcagggt  240
gggccagcc  cacagtgca  cccatttga  aattggtcc  ggtttgcaa  acatgggtg  300
gattctgac  tgctcagtg  caggaatgg  cagctataa  ccagagcat  cacgagtaa  360
aggtttcat  cttcgaggg  tttgttcat  aagagttca  ctccatgca  aatacactg  420
catcatacc  ccatcatcc  aaaaaaagg  gttgggtgt  ttgtgggaa  cactcaggc  480
tgagctttg  gaggacatt  cttctgcct  cctgctctg  gagttatga  gga  533



<210> 4698
<211> 533
<212> DNA
<213> Rattus norvegicus
<308> AA800693
<400> 4698

tatttgtgg  tagtcatag  agtcaacag  ccagcacag  acagacaca  ctacacagt  60
ctcatgtcc  caaacacac  gacagggga  agcacacag  gctgggaga  ttgggctaa  120
accacctaa  tccagagca  gcccctcct  cacagcagg  attgtgggg  caactgtgc  180
ttgctctaa  gaccagggg  ctctgggga  gtgaggtct  tgggaagga  tagcagggt  240
gggccagcc  cacagtgca  cccatttga  aattggtcc  ggtttgcaa  acatgggtg  300
gattctgac  tgctcagtg  caggaatgg  cagctataa  ccagagcat  cacgagtaa  360
aggtttcat  cttcgaggg  tttgttcat  aagagttca  ctccatgca  aatacactg  420
catcatacc  ccatcatcc  aaaaaaagg  gttgggtgt  ttgtgggaa  cactcaggc  480
tgagctttg  gaggacatt  cttctgcct  cctgctctg  gagttatga  gga  533



<210> 4699
<211> 533
<212> DNA
<213> Rattus norvegicus
<308> AA800693
<400> 4699

tatttgtgg  tagtcatag  agtcaacag  ccagcacag  acagacaca  ctacacagt  60
ctcatgtcc  caaacacac  gacagggga  agcacacag  gctgggaga  ttgggctaa  120
accacctaa  tccagagca  gcccctcct  cacagcagg  attgtgggg  caactgtgc  180
ttgctctaa  gaccagggg  ctctgggga  gtgaggtct  tgggaagga  tagcagggt  240
gggccagcc  cacagtgca  cccatttga  aattggtcc  ggtttgcaa  acatgggtg  300
gattctgac  tgctcagtg  caggaatgg  cagctataa  ccagagcat  cacgagtaa  360
aggtttcat  cttcgaggg  tttgttcat  aagagttca  ctccatgca  aatacactg  420
catcatacc  ccatcatcc  aaaaaaagg  gttgggtgt  ttgtgggaa  cactcaggc  480
tgagctttg  gaggacatt  cttctgcct  cctgctctg  gagttatga  gga  533



<210> 4700
<211> 629
<212> DNA
<213> Rattus norvegicus
<308> AA800699
<400> 4700

ggaaaaagg  cctgtttat  attaggaaa  gccggatct  agtagcagc  gaacatgga  60
tctgctcac  ggcctcaca  tcattcctc  ccaaaacaa  atagagttt  cataaaaat  120
gatataacc  aggaaacca  gtacattgg  atgtgacca  tgctattta  atgaaaata  180
cgcgttgca  aagtgagga  taaacaccg  catgcactt  atcctaacg  ttaaggtga  240
aacgcagca  cacttgctt  cttcccgtg  ttgtcccac  atcactaaa  gactgacag  300
cacctgaag  tttcttgtg  gcatctcca  ctgagtaca  cctagatct  accacttcg  360
caacaagaa  cctctggat  gcatctatc  aaccggtat  ttaaacaaa  ttaagggta  420
ttcaccagg  tggagctct  atggggata  caaacactc  aagaagccc  gtttgaaaa  480
gtggaaagt  acagcatcg  cagaatgga  tgctgaggc  tttcaaagc  cagagtcac  540
gtgcagacc  gtatggaca  acacccaga  aagacacca  caccctcca  caagagggt  600
gcatcagat  atggtgaca  tggatgatg  629



<210> 4701
<211> 2492
<212> DNA
<213> Homo sapiens
<308> AK027812
<400> 4701

caaagatgg  atacgtctg  atcttattt  gatacgata  actggagac  attcaccct  60
ttccccaac  ataatttat  ttcatggga  tgcaggcaa  ataggtcac  ggttgccaa  120
tgcattact  atgttggtt  acctcaaag  taacctttt  ctggttgat  atcgaggat  180
tggaaaaag  gaaggagaa  caagtgaag  aggactcta  ttagattct  aagctgtgt  240
agactacgt  atgactaga  ctgaccttg  taaaacaaa  atttttctt  ttggccgtt  300
cttgggtgg  gcagtggct  ttcatttgg  ttctgaaaa  tcacatagg  tttcagcca  360
tatggtgga  aacacattt  taagcatac  acatatggc  agcacttta  tttcattct  420
tccgatgcg  taccttcct  tatggtgct  caaaaataa  tttttgtcc  acagaaaaa  480
ctctcagtg  agaatgcct  cacttttca  ctctggact  tcagatcaa  taattccac  540
agtaatgat  aaacaactt  atgaactct  cccatctcg  actaagaga  tagccattt  600
tccagatgg  actcacaat  acacatggc  gtgccaagg  tatttcact  cacttgaac  660
gttcatcaa  gaagtcgta  agagccatt  tcctgaaga  atggcaaaa  cttcatcta  720
tgtaacaat  atataatgt  tcccttttt  attattgca  tgtatttta  tttgtgcag  780
atgataaag  atgttcctt  tagaagtgt  ttatgtctg  acctgtctg  agagtgaca  840
taaactttg  aaggacttc  ctgctcctt  acgatattc  aaatagttt  ttacattgg  900
aaaactaat  cttgggatt  tttcataca  tttcatcaa  actttcagt  tgattatgt  960
ttcatatct  cagtttaat  tgtcagtat  atagatatt  ttcaaaagt  tcttgttgc  1020
aaagtggtg  aatctgtta  acagatgaa  agctagatg  ggaaagaga  atgtaaaca  1080
gaaaccttt  ggtattgtt  cttaagtaa  tattgggac  atcatggta  gcaaactta  1140
ttctgtaac  gcatttttc  ccttaaaag  taaatgaaa  gcatgatgg  attttattc  1200
ttgaattat  caatgcaac  ttttacatg  aaatagcac  ggtcatata  tgatgtata  1260
ggttatctg  gttatatct  tttttatgt  aactctatt  tgtttttgg  aagaagtga  1320
attgagact  atgtgcagg  tgccattga  ttttgctct  gtgaatgct  agatccagc  1380
ttttcttac  aataaatgg  accctgttt  ccaatacaa  tgtaccgtg  ttttgttag  1440
tacagtctg  atcatggca  gtagaaata  aaatttaga  ttttactgc  gctttgatg  1500
gcatatttg  actttttaa  atttgtaac  ttggtggca  agagaattt  agcttctat  1560
gattttgta  gtcttcagc  gaaccacta  tagcagtca  agtgaagat  agcactact  1620
agaattaaa  taggaagtc  tttatcatt  caggattgt  catactact  tataaaaat  1680
ctcaccttt  attttaaat  ccagtacct  gttatatct  acctatcaa  ggcaagata  1740
catttattg  acttcttga  aataaaagt  acaaaatcc  acaacaaca  caacaaaac  1800
atgttcttg  ttttaatgt  ccagttgct  tgaaataga  ctcctacaa  caaaagaca  1860
ttttaggaa  tcttattta  tgattttaa  agttttaca  gtaggagtg  gggaatgaa  1920
gaattctgg  gctttttga  acaaaacct  ttaccacat  tagcagtta  atggctata  1980
gtgggaagt  ggatttaga  gtatagaaa  gtaagaaaa  cttacttag  aaaaagccc  2040
ttgaaactt  caggattta  ttaataaaa  tacacgcta  gagtcataa  tgtgccaag  2100
tgtttcatg  agtcctcaa  aattagatg  aattgagct  tgtgtaata  tatgtcagc  2160
ttaacatat  atattttga  tattttagc  atatttagt  gctttctgc  agcaactag  2220
acagagaag  aatgggtca  taatcttga  cttaattta  aactttcaa  ggagatagg  2280
ctagaaata  ttttgccaa  tagcattct  attcacttt  tgccggtat  tagaaaaaa  2340
aaattatag  aagtatgat  tctaagaat  tttttctat  aattactaa  tgtaaaaag  2400
cttgctttt  aaaacaagt  ggtaatgca  atcatggaa  gcatatttt  tatgtataa  2460
ttcaccaca  ttaaagatt  ttcttgtca  tc  2492



<210> 4702
<211> 202
<212> PRT
<213> Homo sapiens
<308> AK027812
<400> 4702

Met Leu Val Asn Leu Lys Val Asn Leu Leu Leu Val Asp Tyr Arg Gly 
  1               5                  10                  15
Tyr Gly Lys Ser Glu Gly Glu Ala Ser Glu Glu Gly Leu Tyr Leu Asp 
             20                  25                  30
Ser Glu Ala Val Leu Asp Tyr Val Met Thr Arg Pro Asp Leu Asp Lys 
         35                  40                  45
Thr Lys Ile Phe Leu Phe Gly Arg Ser Leu Gly Gly Ala Val Ala Ile 
     50                  55                  60
His Leu Ala Ser Glu Asn Ser His Arg Ile Ser Ala Ile Met Val Glu 
 65                  70                  75                  80
Asn Thr Phe Leu Ser Ile Pro His Met Ala Ser Thr Leu Phe Ser Phe 
                 85                  90                  95
Phe Pro Met Arg Tyr Leu Pro Leu Trp Cys Tyr Lys Asn Lys Phe Leu 
             100                105                110
Ser Tyr Arg Lys Ile Ser Gln Cys Arg Met Pro Ser Leu Phe Ile Ser 
         115                120                125
Gly Leu Ser Asp Gln Leu Ile Pro Pro Val Met Met Lys Gln Leu Tyr 
     130                135                140
Glu Leu Ser Pro Ser Arg Thr Lys Arg Leu Ala Ile Phe Pro Asp Gly 
 145                150                155                160
Thr His Asn Asp Thr Trp Gln Cys Gln Gly Tyr Phe Thr Ala Leu Glu 
                 165                170                175
Gln Phe Ile Lys Glu Val Val Lys Ser His Ser Pro Glu Glu Met Ala 
             180                185                190
Lys Thr Ser Ser Asn Val Thr Ile Ile Ter 
         195                200



<210> 4703
<211> 629
<212> DNA
<213> Rattus norvegicus
<308> AA800699
<400> 4703

ggaaaaagg  cctgtttat  attaggaaa  gccggatct  agtagcagc  gaacatgga  60
tctgctcac  ggcctcaca  tcattcctc  ccaaaacaa  atagagttt  cataaaaat  120
gatataacc  aggaaacca  gtacattgg  atgtgacca  tgctattta  atgaaaata  180
cgcgttgca  aagtgagga  taaacaccg  catgcactt  atcctaacg  ttaaggtga  240
aacgcagca  cacttgctt  cttcccgtg  ttgtcccac  atcactaaa  gactgacag  300
cacctgaag  tttcttgtg  gcatctcca  ctgagtaca  cctagatct  accacttcg  360
caacaagaa  cctctggat  gcatctatc  aaccggtat  ttaaacaaa  ttaagggta  420
ttcaccagg  tggagctct  atggggata  caaacactc  aagaagccc  gtttgaaaa  480
gtggaaagt  acagcatcg  cagaatgga  tgctgaggc  tttcaaagc  cagagtcac  540
gtgcagacc  gtatggaca  acacccaga  aagacacca  caccctcca  caagagggt  600
gcatcagat  atggtgaca  tggatgatg  629



<210> 4704
<211> 2492
<212> DNA
<213> Homo sapiens
<308> AK027812
<400> 4704

caaagatgg  atacgtctg  atcttattt  gatacgata  actggagac  attcaccct  60
ttccccaac  ataatttat  ttcatggga  tgcaggcaa  ataggtcac  ggttgccaa  120
tgcattact  atgttggtt  acctcaaag  taacctttt  ctggttgat  atcgaggat  180
tggaaaaag  gaaggagaa  caagtgaag  aggactcta  ttagattct  aagctgtgt  240
agactacgt  atgactaga  ctgaccttg  taaaacaaa  atttttctt  ttggccgtt  300
cttgggtgg  gcagtggct  ttcatttgg  ttctgaaaa  tcacatagg  tttcagcca  360
tatggtgga  aacacattt  taagcatac  acatatggc  agcacttta  tttcattct  420
tccgatgcg  taccttcct  tatggtgct  caaaaataa  tttttgtcc  acagaaaaa  480
ctctcagtg  agaatgcct  cacttttca  ctctggact  tcagatcaa  taattccac  540
agtaatgat  aaacaactt  atgaactct  cccatctcg  actaagaga  tagccattt  600
tccagatgg  actcacaat  acacatggc  gtgccaagg  tatttcact  cacttgaac  660
gttcatcaa  gaagtcgta  agagccatt  tcctgaaga  atggcaaaa  cttcatcta  720
tgtaacaat  atataatgt  tcccttttt  attattgca  tgtatttta  tttgtgcag  780
atgataaag  atgttcctt  tagaagtgt  ttatgtctg  acctgtctg  agagtgaca  840
taaactttg  aaggacttc  ctgctcctt  acgatattc  aaatagttt  ttacattgg  900
aaaactaat  cttgggatt  tttcataca  tttcatcaa  actttcagt  tgattatgt  960
ttcatatct  cagtttaat  tgtcagtat  atagatatt  ttcaaaagt  tcttgttgc  1020
aaagtggtg  aatctgtta  acagatgaa  agctagatg  ggaaagaga  atgtaaaca  1080
gaaaccttt  ggtattgtt  cttaagtaa  tattgggac  atcatggta  gcaaactta  1140
ttctgtaac  gcatttttc  ccttaaaag  taaatgaaa  gcatgatgg  attttattc  1200
ttgaattat  caatgcaac  ttttacatg  aaatagcac  ggtcatata  tgatgtata  1260
ggttatctg  gttatatct  tttttatgt  aactctatt  tgtttttgg  aagaagtga  1320
attgagact  atgtgcagg  tgccattga  ttttgctct  gtgaatgct  agatccagc  1380
ttttcttac  aataaatgg  accctgttt  ccaatacaa  tgtaccgtg  ttttgttag  1440
tacagtctg  atcatggca  gtagaaata  aaatttaga  ttttactgc  gctttgatg  1500
gcatatttg  actttttaa  atttgtaac  ttggtggca  agagaattt  agcttctat  1560
gattttgta  gtcttcagc  gaaccacta  tagcagtca  agtgaagat  agcactact  1620
agaattaaa  taggaagtc  tttatcatt  caggattgt  catactact  tataaaaat  1680
ctcaccttt  attttaaat  ccagtacct  gttatatct  acctatcaa  ggcaagata  1740
catttattg  acttcttga  aataaaagt  acaaaatcc  acaacaaca  caacaaaac  1800
atgttcttg  ttttaatgt  ccagttgct  tgaaataga  ctcctacaa  caaaagaca  1860
ttttaggaa  tcttattta  tgattttaa  agttttaca  gtaggagtg  gggaatgaa  1920
gaattctgg  gctttttga  acaaaacct  ttaccacat  tagcagtta  atggctata  1980
gtgggaagt  ggatttaga  gtatagaaa  gtaagaaaa  cttacttag  aaaaagccc  2040
ttgaaactt  caggattta  ttaataaaa  tacacgcta  gagtcataa  tgtgccaag  2100
tgtttcatg  agtcctcaa  aattagatg  aattgagct  tgtgtaata  tatgtcagc  2160
ttaacatat  atattttga  tattttagc  atatttagt  gctttctgc  agcaactag  2220
acagagaag  aatgggtca  taatcttga  cttaattta  aactttcaa  ggagatagg  2280
ctagaaata  ttttgccaa  tagcattct  attcacttt  tgccggtat  tagaaaaaa  2340
aaattatag  aagtatgat  tctaagaat  tttttctat  aattactaa  tgtaaaaag  2400
cttgctttt  aaaacaagt  ggtaatgca  atcatggaa  gcatatttt  tatgtataa  2460
ttcaccaca  ttaaagatt  ttcttgtca  tc  2492



<210> 4705
<211> 202
<212> PRT
<213> Homo sapiens
<308> AK027812
<400> 4705

Met Leu Val Asn Leu Lys Val Asn Leu Leu Leu Val Asp Tyr Arg Gly 
  1               5                  10                  15
Tyr Gly Lys Ser Glu Gly Glu Ala Ser Glu Glu Gly Leu Tyr Leu Asp 
             20                  25                  30
Ser Glu Ala Val Leu Asp Tyr Val Met Thr Arg Pro Asp Leu Asp Lys 
         35                  40                  45
Thr Lys Ile Phe Leu Phe Gly Arg Ser Leu Gly Gly Ala Val Ala Ile 
     50                  55                  60
His Leu Ala Ser Glu Asn Ser His Arg Ile Ser Ala Ile Met Val Glu 
 65                  70                  75                  80
Asn Thr Phe Leu Ser Ile Pro His Met Ala Ser Thr Leu Phe Ser Phe 
                 85                  90                  95
Phe Pro Met Arg Tyr Leu Pro Leu Trp Cys Tyr Lys Asn Lys Phe Leu 
             100                105                110
Ser Tyr Arg Lys Ile Ser Gln Cys Arg Met Pro Ser Leu Phe Ile Ser 
         115                120                125
Gly Leu Ser Asp Gln Leu Ile Pro Pro Val Met Met Lys Gln Leu Tyr 
     130                135                140
Glu Leu Ser Pro Ser Arg Thr Lys Arg Leu Ala Ile Phe Pro Asp Gly 
 145                150                155                160
Thr His Asn Asp Thr Trp Gln Cys Gln Gly Tyr Phe Thr Ala Leu Glu 
                 165                170                175
Gln Phe Ile Lys Glu Val Val Lys Ser His Ser Pro Glu Glu Met Ala 
             180                185                190
Lys Thr Ser Ser Asn Val Thr Ile Ile Ter 
         195                200



<210> 4706
<211> 636
<212> DNA
<213> Rattus norvegicus
<308> AA800701
<400> 4706

agcattttc  aactttatt  acaactgtc  cagtgacaa  aagtagttt  gaaaaaaaa  60
atgctagtt  ctccctgag  ctcgataca  aacagacag  agtcacagg  ggttcatct  120
acaacaggc  tgtcactga  atactagga  ttttttttt  aatacgatc  gttagaaat  180
cacacaaat  acttaaaga  agaagagga  gaagagggg  agagaaaga  aaagagaaa  240
agaaagaga  gaagaggcc  gacaggagc  cagccactt  tccaagagc  gctgggtcc  300
cccaacagg  tcaaccgct  aggggcctg  cgttagcta  cagcccctg  cctgctcag  360
caacacacg  ttgtacaac  tggtctagt  accggcaaa  ggaagaagc  accccacag  420
cacacatat  cacaaagct  attgatact  gatttacaa  cacatcccg  cacacggca  480
gaccaagac  gatcggggt  ggggtgaga  gacaccaan  cacaggaat  tcaaaggcc  540
aacacctgt  cataaaggg  ggcgaggga  gagaaatgc  gtgggagaa  gggagaagg  600
tgaacagat  tctgtagcc  aaacagaac  gagtgg  636



<210> 4707
<211> 497
<212> DNA
<213> Homo sapiens
<308> BF109813
<400> 4707

tttttttaa  cattttcaa  ctttattta  aactgtcac  gtgacaaaa  gtagtttgg  60
aaaaaaaaa  gctagtttc  ccctgagcc  caaaaaaga  cagatagaa  ttacaaaaa  120
ctttttaaa  aattatata  acaatgtca  ccatagaag  tttaagtac  ttaaatcat  180
aactctgta  tttgtatag  agtcttata  aaatatagt  agctctcaa  tgtttaatg  240
cacttaagt  agttaaagt  cagattgta  agcatatta  gaaggtgcc  agaatacca  300
tgtctcctg  acttaacac  ttaatacaa  gtttgccaa  tgttttgaa  ttccaaatg  360
attcctgaa  aaaaaaaga  cctaaacac  atattatag  catatgtta  aaaagtcct  420
gaaatgcac  caatttcct  ccattttac  ttcctacat  gattgaagt  agcccctca  480
aagcttttc  gctgggc  497



<210> 4708
<211> 295
<212> PRT
<213> Homo sapiens
<308> P13726
<400> 4708

Met Glu Thr Pro Ala Trp Pro Arg Val Pro Arg Pro Glu Thr Ala Val 
  1               5                  10                  15
Ala Arg Thr Leu Leu Leu Gly Trp Val Phe Ala Gln Val Ala Gly Ala 
             20                  25                  30
Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
         35                  40                  45
Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
     50                  55                  60
Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
 65                  70                  75                  80
Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
                 85                  90                  95
Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
             100                105                110
Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
         115                120                125
Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
     130                135                140
Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
 145                150                155                160
Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
                 165                170                175
Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
             180                185                190
Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
         195                200                205
Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
     210                215                220
Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
 225                230                235                240
Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Ile Phe Tyr Ile Ile 
                 245                250                255
Gly Ala Val Val Phe Val Val Ile Ile Leu Val Ile Ile Leu Ala Ile 
             260                265                270
Ser Leu His Lys Cys Arg Lys Ala Gly Val Gly Gln Ser Trp Lys Glu 
         275                280                285
Asn Ser Pro Leu Asn Val Ser 
     290                295



<210> 4709
<211> 641
<212> DNA
<213> Rattus norvegicus
<308> AA800708
<400> 4709

gataaaagg  aggtaggaa  ttaatgacg  atagcccat  ttggttgct  aacaccagg  60
tgctgtcca  ggaaccatc  ttaaataaa  caacctgaa  acagagttc  cacacacac  120
agcacactc  cggactctg  aactcttgg  atcattaaa  cactacttt  acgaacaga  180
gtaaaatca  actaaaatg  gaagtgggc  caaacttca  gaatagtgc  gattgtcta  240
gaacatcat  ttcttttat  attttccat  tacttttca  atatatgta  agtctctag  300
ctgtaaaag  gaccgagtg  ctcaaagga  gaactaccc  cctccttct  tctcagaac  360
aagtcattt  agctcataa  cgtcttcaa  tttcactta  taaagacag  aaatgaagc  420
ggcttttga  caagttccc  aggaaataa  tagtacata  acctccaac  cagcaaccc  480
ctggatcaa  gaatcttta  cctttcgag  atgaaccac  gtcacaagc  tatcctgaa  540
aaacgctat  cttctaaga  tgaagacag  gaacggcca  ctgggcgat  gaatttcat  600
tgatgcagg  acattccct  aagaggaga  acagagtca  a  641



<210> 4710
<211> 663
<212> DNA
<213> Rattus norvegicus
<308> AA800719
<400> 4710

gaaaagcag  cttttaata  ctaattgaa  ccagtgagt  ggaaagact  aaaacatat  60
tccccttga  aataccttt  caagaacaa  aggccagag  cgtctcttc  atgggaaac  120
gacatcccc  gtgtgctca  aaaagtgag  tctcaactc  tatgcatgc  acatagttt  180
caccccatc  caccctgcc  accctccac  ggtgacaga  tcacacacc  aagggactg  240
tttcttaaa  cgtggaaca  aatgtttaa  agaagataa  tctagccaa  tggccagat  300
ccagaaata  ctcaggggc  gttttacat  cacaataaa  gtcaactca  ataaaaagg  360
aagttttgc  aattggaat  agaggcaaa  attacaaat  gcagagaat  cagctaccc  420
tatgagatt  tttaagaaa  acaaaaaac  aaaccaaac  aaaaaaaaa  aaaaaaaca  480
ccccaaacc  caaaagtcc  tactggaga  tcccttcat  acaaaagta  gcaaacatc  540
caatataaa  gaagcccag  cccacggct  gctctctct  gacaggaga  catagctaa  600
attccccgt  tggaattca  gcctggacc  atgccccac  ctttgggaa  gaaagggaa  660
gat  663



<210> 4711
<211> 1554
<212> DNA
<213> Homo sapiens
<308> AL133060
<400> 4711

gccaggctt  gacaatctc  cagccccca  taggtggac  cattaatga  ttggtttct  60
ccctgggca  ccaacctgc  ccagaggca  cagacctgg  ctttcagct  tgggaccag  120
ctgcccaaa  gtactcctt  atacacccg  caccttcca  gaaagatgg  acttcccaa  180
caagcccct  tgatttgtc  ctatagatg  aaccctgac  tctgcccca  cccttcctg  240
ccaacctag  acccaggcc  caagtcttt  ccccacccc  ttcttgttc  tccaagaag  300
agatgccca  ttgctcagc  gcagcggta  agacttgaa  ctgcccacc  gtcacaagg  360
gggtcacag  ttcctcttc  tctcttctc  tcgttcctc  gaaccctcc  ccaatgtgc  420
tcagcctgt  tgctgtgtg  caacagcat  ctggttccc  ctgccaaga  ctcccacca  480
tctgctggg  tctgcagtg  cagggagtg  gggttgtgt  aaggggaag  catcttttg  540
gatccagat  gacatggtt  gtgcactta  gtccagatg  gaagcatcc  tcctgcaac  600
ctaaaataa  catgcagcc  ctcagacgg  cgccatcgg  cccaaggcc  taggtggag  660
aagcaaagc  ggccaggcc  gtcctgtcc  tggacctct  ccttctgga  tccctacgg  720
tgcagagca  ttgggtttc  ctacagcca  cgtggccca  ttgacactg  gctcctcca  780
cagctggtc  catgccaac  cgttcccag  ccctgaggc  gctccaggg  gccccacct  840
ctcctgagg  gggtcccta  cctgctgct  ctcttcatc  tttcccttt  gtcctgaaa  900
ggaggagca  tggtccagg  attaattcc  cccagggaa  tttagctat  ccctcatgt  960
ccagggaga  agccacacg  ctgttttcc  tttatagca  gattgtttg  atacttttg  1020
aatgaaggg  agtgtccag  ggaaggatt  ttaaaatta  cttatggat  gctcaagtc  1080
ctgccattt  taatttttg  ctctaagct  cgattggag  cgcttctcc  tgtgcatgt  1140
agttgactg  tgttgtgag  gtaaatgca  ttggttatt  ctggtatcg  tggccactt  1200
gatggattt  tttacattc  gttccccag  tacaggaag  agtcccttt  gtgtgtgaa  1260
atgtgtgcc  gtagagggt  gggcagggt  gggtgggga  ggaaatgtg  ggcatgcac  1320
tgagttgaa  ttcttttat  cattttttt  aagaaaaaa  aaaaaacaa  tctgaggac  1380
taggggatg  cagtttcct  tggaagaga  acctctgac  cgttattct  ataatcaaa  1440
tctgaaggg  aaaaaatgt  ttagttctt  ccccactcg  tgggttcaa  tagattaaa  1500
ggctgattt  cagaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaggggc  gccg  1554



<210> 4712
<211> 663
<212> DNA
<213> Rattus norvegicus
<308> AA800719
<400> 4712

gaaaagcag  cttttaata  ctaattgaa  ccagtgagt  ggaaagact  aaaacatat  60
tccccttga  aataccttt  caagaacaa  aggccagag  cgtctcttc  atgggaaac  120
gacatcccc  gtgtgctca  aaaagtgag  tctcaactc  tatgcatgc  acatagttt  180
caccccatc  caccctgcc  accctccac  ggtgacaga  tcacacacc  aagggactg  240
tttcttaaa  cgtggaaca  aatgtttaa  agaagataa  tctagccaa  tggccagat  300
ccagaaata  ctcaggggc  gttttacat  cacaataaa  gtcaactca  ataaaaagg  360
aagttttgc  aattggaat  agaggcaaa  attacaaat  gcagagaat  cagctaccc  420
tatgagatt  tttaagaaa  acaaaaaac  aaaccaaac  aaaaaaaaa  aaaaaaaca  480
ccccaaacc  caaaagtcc  tactggaga  tcccttcat  acaaaagta  gcaaacatc  540
caatataaa  gaagcccag  cccacggct  gctctctct  gacaggaga  catagctaa  600
attccccgt  tggaattca  gcctggacc  atgccccac  ctttgggaa  gaaagggaa  660
gat  663



<210> 4713
<211> 1554
<212> DNA
<213> Homo sapiens
<308> AL133060
<400> 4713

gccaggctt  gacaatctc  cagccccca  taggtggac  cattaatga  ttggtttct  60
ccctgggca  ccaacctgc  ccagaggca  cagacctgg  ctttcagct  tgggaccag  120
ctgcccaaa  gtactcctt  atacacccg  caccttcca  gaaagatgg  acttcccaa  180
caagcccct  tgatttgtc  ctatagatg  aaccctgac  tctgcccca  cccttcctg  240
ccaacctag  acccaggcc  caagtcttt  ccccacccc  ttcttgttc  tccaagaag  300
agatgccca  ttgctcagc  gcagcggta  agacttgaa  ctgcccacc  gtcacaagg  360
gggtcacag  ttcctcttc  tctcttctc  tcgttcctc  gaaccctcc  ccaatgtgc  420
tcagcctgt  tgctgtgtg  caacagcat  ctggttccc  ctgccaaga  ctcccacca  480
tctgctggg  tctgcagtg  cagggagtg  gggttgtgt  aaggggaag  catcttttg  540
gatccagat  gacatggtt  gtgcactta  gtccagatg  gaagcatcc  tcctgcaac  600
ctaaaataa  catgcagcc  ctcagacgg  cgccatcgg  cccaaggcc  taggtggag  660
aagcaaagc  ggccaggcc  gtcctgtcc  tggacctct  ccttctgga  tccctacgg  720
tgcagagca  ttgggtttc  ctacagcca  cgtggccca  ttgacactg  gctcctcca  780
cagctggtc  catgccaac  cgttcccag  ccctgaggc  gctccaggg  gccccacct  840
ctcctgagg  gggtcccta  cctgctgct  ctcttcatc  tttcccttt  gtcctgaaa  900
ggaggagca  tggtccagg  attaattcc  cccagggaa  tttagctat  ccctcatgt  960
ccagggaga  agccacacg  ctgttttcc  tttatagca  gattgtttg  atacttttg  1020
aatgaaggg  agtgtccag  ggaaggatt  ttaaaatta  cttatggat  gctcaagtc  1080
ctgccattt  taatttttg  ctctaagct  cgattggag  cgcttctcc  tgtgcatgt  1140
agttgactg  tgttgtgag  gtaaatgca  ttggttatt  ctggtatcg  tggccactt  1200
gatggattt  tttacattc  gttccccag  tacaggaag  agtcccttt  gtgtgtgaa  1260
atgtgtgcc  gtagagggt  gggcagggt  gggtgggga  ggaaatgtg  ggcatgcac  1320
tgagttgaa  ttcttttat  cattttttt  aagaaaaaa  aaaaaacaa  tctgaggac  1380
taggggatg  cagtttcct  tggaagaga  acctctgac  cgttattct  ataatcaaa  1440
tctgaaggg  aaaaaatgt  ttagttctt  ccccactcg  tgggttcaa  tagattaaa  1500
ggctgattt  cagaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaggggc  gccg  1554



<210> 4714
<211> 552
<212> DNA
<213> Rattus norvegicus
<308> AA800735
<400> 4714

caatgtaaa  tgatcaatg  gttgtgatt  ctctgaaat  ttatttttg  gatcctgtg  60
cacaaaatg  cgtgtgtaa  gtttacaat  ggtatgaga  attgagatg  ttttatctc  120
actgagaat  aaactgtag  taaggttcc  agccggcat  aaaagagca  agcaaactt  180
tctgtatat  aactgtaca  aaaacaagg  actatacac  tccgggggg  acattaagg  240
agaaaggtt  attcagata  attcttcag  gtcacaccg  gaagtagta  aaagtcttt  300
ctcgcttta  caccggaag  agaactcgg  acaagccag  cctaaggct  aggaggcag  360
cctgagcct  ggagagact  gtggcaggc  taggtcaac  gaagtgaca  agccctaca  420
ttggtaatg  ccttttgac  ccaaaggga  cagttgcaa  tgaatgaat  catagcttg  480
taaatacat  gttgcttta  atggtgttt  tataaatat  tatatatat  tagaattca  540
aaactatca  aa  552



<210> 4715
<211> 6719
<212> DNA
<213> Homo sapiens
<308> AF051850
<400> 4715

tcggcggga  gcggcgatc  tgccaccgg  aggtgtgga  gagccgggt  gattctggc  60
acattggag  ttggttgct  tctaaaact  aaggagaag  ccatgaaga  atggtggat  120
ctcactgag  tttgactag  ggaagaaaa  agagagttc  agtggatgg  cttgaggac  180
tgaaaagct  agatatgat  attttgaag  catttcaca  cgaagccat  atttaaata  240
cggcgttaa  atttcaaca  gaaaaactt  agcttcctt  gattcccac  tcaaaggaa  300
gtttcaagc  ttcagaagg  gttctcact  gaagataaa  aacagctcg  taaccacga  360
agaggaatc  atgctcagc  tttagttgc  cttcctaaa  ttgcagaat  aagacaaat  420
tttgaacca  agaagaaag  attcttaga  atgaaaaga  aagaaagaa  tgccaggcg  480
ctggaaggg  ttgaaaatg  cactcagcc  atcctcttg  agagctgca  aggattggt  540
actcaccgc  tgctggagg  agacacccc  cgatacatg  gagccagcg  ccctgccag  600
ccccacatc  gccgatcaa  tgaagagga  gaaacttct  attcttctc  agaaaagca  660
actcgatcc  aatactgca  agaaacctc  ggtgtccac  gtgactcac  ctatggttc  720
ggtaccatg  acacccaca  tctggagtc  aaagccgaa  gaattgcaa  gtacaaagc  780
gaaagaagg  gacagctgg  agagaagta  gggctgact  tggatcccg  ggccgactc  840
gagtattta  cccgctata  caagtccag  aaggagcct  atgctgtcg  gaagcgggg  900
ggaaaaagt  acaaacagg  agagtcaag  agagatgcg  gttctctgt  ccccgggac  960
gagacgatg  ggctcagga  ctgtgccgg  gaatccaag  actatgccc  ccatgcggg  1020
gacggctct  ccgacccgg  ggtgctgct  aacatagaa  accaaagac  aggtcaaga  1080
ctgagtgcc  cccggcagg  ccatgacct  tccccagca  ccgagagtt  ctcgacctt  1140
tctttctct  ggcgagact  ctccttcac  gaagtgcca  ggtccccca  gcacgccca  1200
agctcctcc  tgcagcagg  agcctcccg  agcccctcc  ttggtgacc  acagctatc  1260
cctgaggcc  gacccaggt  cacttcaca  tcagaaacg  caactgtcg  tgatgaaga  1320
aaggtggat  aacgagcca  gctgagcgt  gccgccaag  ggttgcttt  cagggagat  1380
gaaaaatct  ttgatgaac  aaatgttcc  aagcgacgc  caagaaaca  agctgtgga  1440
cagaggcta  gccgtctgc  ggacaggtc  ctcacccag  ccatcacca  tgaagaggt  1500
gtcatcgca  ccacattgc  ggcctctgc  caccaaaag  ccttagcca  ggaccagac  1560
aatgagggc  aagagcttg  tgagcaagg  gaacctgat  cctccactc  aagcttggc  1620
gaaaagttg  ccttgttta  caaattgtc  cagccagtc  caaaagcga  ttctacccg  1680
aacagaata  acacgagac  gaggagaat  aacgctcgc  atcaaactc  gccagtcac  1740
ctgggagag  tggagcagg  gcagagtgg  aagctcatt  ctttctcac  tgccgtgaa  1800
acatcagtg  ctaccgtag  atccacggt  gctccaatg  atgccggag  tcttcgcac  1860
aagccacct  ttgaccaca  tgcaagtgc  actgactat  agttttctt  ttcaataga  1920
aattcggac  ctccagtta  aagcattct  aaatcgcaa  cttggcagc  tttggtaga  1980
ggtagcgag  acaagggaa  gttgagaga  tatggagag  cagaaagca  gagagcttt  2040
acaggtcga  acagtggga  ggagaagta  gggtccttt  aggaagcag  agcatccta  2100
cccatcctg  acagagcca  ggaaggaga  agccataag  aatctaaat  tgctgttcc  2160
agaagagga  gcctggaac  ggcgaaccc  cccatcacc  acctcgggg  tgaaccgaa  2220
gaattttcc  tggctaaaa  gaatgcaca  ggaaacttg  acttgaggg  caggctgcc  2280
tttgaagag  aggtggagg  ggagaatgt  atgaaaagg  agttttcac  aagagcggc  2340
gagttcggg  agcccactt  cgagcagac  gggacagct  ctgggaaaa  tattgctca  2400
accacagcc  ccgtgtcct  gaagcccca  gattcttcg  aacagccac  ggagaagct  2460
tgcaagaat  catgtgcga  gtttgctgc  ggagagatc  aaacgccga  aggggaggg  2520
cttcttgac  cacccagca  aaccatgtc  attaaagaa  gattggcac  gttgaagaa  2580
agcggggag  aagattgga  aaacagact  agcaggagg  aggagggcg  caaggcgcc  2640
gccagcagc  tgcacaccc  ggaagcagg  cggtccctc  tcaagaagc  ggtcacaga  2700
agtcgagag  gccaaatga  gattgagga  aggaagcag  tcatcactg  gagagagga  2760
gcctggaag  cgagaggca  aggagcggc  aacgactcg  cccagttca  tgtggctgg  2820
aggatggtg  agaaaggtt  ggcgtcacc  actgccata  ccccagtag  ctcagccat  2880
tgcggtaaa  caagaggca  cacacccgt  tccaaaccc  tggaagata  cgaagccag  2940
ccagatatg  agttagaat  ggacctgaa  ttggacagg  tggaaacct  tctaagaag  3000
ctgaataac  aagttggcg  gatgcacga  acggtgctc  ctgtcaccg  caaatctgt  3060
aaggaggtg  tgaagccag  tgatgatga  acctttgcc  aattttacc  cagcgtgga  3120
tataatatg  caagaagtc  tgtggagat  gatgaggac  tcgatgtca  tttcgatcc  3180
tatgcaccc  aattgacgt  ttccgtggc  gagcacaag  gggcagtta  gcccaagcg  3240
cgggttcag  cctccaaaa  ccccctgaa  atgctggcg  caagagaag  tctccttca  3300
gaatacact  agcagagat  aaacgttgc  ttcatggag  caaagcgga  gaaagtaga  3360
aagatgtct  ccaactcca  cttctcaga  gtcaccctg  cgggtttag  cagtaaaga  3420
aacttcagc  acgtcagcc  gcggagcgt  aacctgacg  aacagaact  taacaacag  3480
gccgtgccc  acaagaggc  gatgctgtt  cagattaaa  gaagaagac  tgtgcagac  3540
aggctggtg  aacctcgag  ttcggcgct  aacagtggg  actgcttcc  cctgctctc  3600
ccccactgc  gcttcctgt  ggtaggaga  tttgcaaac  tcatagaaa  ggcgaaggc  3660
tcagaactt  caactttaa  tcagacaaa  agggaactt  gttgtagag  tacttatat  3720
caaaccatt  aagaaggaa  taatacaca  actcatgca  ccaaagact  ctggaagct  3780
ctgggtggc  aaaccagtt  ccaatctgc  ggagaccca  aagaagatg  actctatga  3840
gcagccata  tagaaacta  ctgcattta  cgtctcatg  atgacaaac  tgttcctga  3900
gacgactac  gggggaaaa  tccgaagtg  tcccttctg  aacccaaag  ggtactggt  3960
tttgatttt  gtagtgaag  ttacgtatg  catgggaaa  aagtcacat  agcacaacg  4020
aaaatagca  ttcagctgg  aaagcactt  tggaatgga  cctttgact  tgagaactg  4080
gacatcaat  ccctggatc  tggagaatg  aatccgctt  tccccagaa  aggacaggg  4140
cggcccgac  gggcgatat  tgggagact  actgaacac  atgagacga  tttgttcaa  4200
gagaagttt  tggattgga  ggaactgaa  agatcgaat  agaagaacc  cggggaact  4260
gcccagcac  aggaagacc  caggactga  gtcaaggca  acgatgtga  acggatggt  4320
tccatgccc  agacgacag  aggcaccat  ctggacgga  tgaacgtcg  ccgtggcta  4380
ggcctggtg  aaggacacg  caggaggca  tttgagatc  ccagcgttt  cgtggatgt  4440
tggcacatc  tggaattcg  ctatagcag  ctccccaaa  aaagcatcg  gcagttcca  4500
gagggggat  cctatgtgg  caagtggaa  ttcatggtg  gcacggcag  gggaagtcg  4560
cagaaggga  agcactcgg  gagggcagc  ggcaaagag  agtgcgtct  cttcttctg  4620
caaggccgg  actccaccg  gagtgagaa  ggcacgtcg  cgctgatga  ggtggagct  4680
gacgaggaa  ggggggccc  ggtccaggt  ctccaggga  aggagcccc  ctgtttcct  4740
cagtgtttc  aggggggga  ggtggtgca  tcggggagg  gggaagagg  agaagaaaa  4800
gtgcaaagt  agtggcggc  gtactgcgt  cgtggagag  tgcccgtgg  agggaattt  4860
ctggaagtg  cctgtcact  tagcagcct  aggtccaga  cttccatgg  ggtgcttaa  4920
gtcaacaag  ccctcatct  cctgtggca  ggatgcaaa  cccaggccc  cacgaagga  4980
gtcggaagg  ccgctgcga  caagatcaa  gaacaatgt  ccctggaag  aggactgca  5040
agtagcagc  aagtcacaa  acacgagtg  gatgaaggc  ccgagccac  cggattctg  5100
gatgcctta  gaaggagag  caggaaagc  tacgattgc  tgcttcaag  tcctggaag  5160
tttaacttc  cgccccgcc  gttcatcct  agcagctcc  ctggggatt  tgcagccac  5220
gagtttgtg  accctgccc  agccccctc  gtggtcagt  ccatgccct  cctgcagga  5280
gatctgtac  gcgcgcccc  gccagcact  ttccttgtt  acaatcacc  cgaggtgta  5340
ctctggcaa  gctggtggc  catcgagaa  aagatcact  gttccgccc  catccgctg  5400
gcctccgac  ggaagagtg  gatggagac  gtgctccag  actgcaaag  aaaaaatct  5460
aagaaacca  cccccaagt  ttaccttat  cacgctggt  tggagcccc  gacattcac  5520
aatatgttt  ccagctggg  gcacagaga  gacatcgct  agatcacag  gatggacac  5580
gaagtttcc  atcagatca  cctcgtgga  gacgtctta  ccaagctct  taaaaccat  5640
tacccgctg  ccgacctcc  ggccaggcc  ctcccggag  gggtcgatc  tctgaagct  5700
gagatctat  tcaccgacg  agacttcga  tttgcacta  acatgacga  ggatgaata  5760
aacgccctg  ccgcctgga  gcaggtgaa  ctgaagaaa  caaaaggcc  gttctgagt  5820
gggagacgc  agaggagcc  cacggtcac  tccaacaac  ccactgcac  agggaaatg  5880
atatatatt  ttggactgg  gtttttcac  aagtatttt  caatcagag  tttcagaac  5940
tgacattgt  aaagatact  cttgtcccg  agttgtgta  tttgtaaat  ttcaaggga  6000
ctgtttgga  acttctttc  accattcag  aggttatca  aattaataa  agtatctgt  6060
atgtgcact  aagccgcag  tgctataga  agcactgcc  tcttgttcc  gctaggcaa  6120
gcctttttt  ttttttttg  agcagttct  tttataaag  gttattttg  tagtttgtg  6180
attctaaaa  atatatata  ttatataaa  accatataa  tcaaatatg  atttaacaa  6240
gcaatatgt  ttcattcac  ttcaagatt  gttttggtg  caaaataac  tgaaaaggt  6300
gatggagtt  cttctgttg  attagctct  ccaccaata  gtatcttca  acacgtttg  6360
aaatgtttc  tgcagcatt  ggtatgact  gttctgagt  ctgcttccg  tgctaaaat  6420
aacaaagaa  ttgtactta  tggcatgga  tctggagaa  ctatgcgaa  caacctttc  6480
accttaata  ctccccaaa  atgtatagt  ccttgtttt  atgtacagt  tatatacag  6540
aaagtttgc  ctgcatttt  gatgatggt  tggaacatt  tctacaatt  tactctcaa  6600
tagtcaaaa  aaaaacatc  caatttcta  taccggttg  aaacaaaca  tacacatgt  6660
attttgtga  ataggactc  caaataaaa  tatcagaat  aacacaaca  ttaactggt  6719



<210> 4716
<211> 1789
<212> PRT
<213> Homo sapiens
<308> AF051850
<400> 4716

Met Lys Arg Lys Glu Arg Ile Ala Arg Arg Leu Glu Gly Ile Glu Asn 
  1               5                  10                  15
Asp Thr Gln Pro Ile Leu Leu Gln Ser Cys Thr Gly Leu Val Thr His 
             20                  25                  30
Arg Leu Leu Glu Glu Asp Thr Pro Arg Tyr Met Arg Ala Ser Asp Pro 
         35                  40                  45
Ala Ser Pro His Ile Gly Arg Ser Asn Glu Glu Glu Glu Thr Ser Asp 
     50                  55                  60
Ser Ser Leu Glu Lys Gln Thr Arg Ser Lys Tyr Cys Thr Glu Thr Ser 
 65                  70                  75                  80
Gly Val His Gly Asp Ser Pro Tyr Gly Ser Gly Thr Met Asp Thr His 
                 85                  90                  95
Ser Leu Glu Ser Lys Ala Glu Arg Ile Ala Arg Tyr Lys Ala Glu Arg 
             100                105                110
Arg Arg Gln Leu Ala Glu Lys Tyr Gly Leu Thr Leu Asp Pro Glu Ala 
         115                120                125
Asp Ser Glu Tyr Leu Ser Arg Tyr Thr Lys Ser Arg Lys Glu Pro Asp 
     130                135                140
Ala Val Glu Lys Arg Gly Gly Lys Ser Asp Lys Gln Glu Glu Ser Ser 
 145                150                155                160
Arg Asp Ala Ser Ser Leu Tyr Pro Gly Thr Glu Thr Met Gly Leu Arg 
                 165                170                175
Thr Cys Ala Gly Glu Ser Lys Asp Tyr Ala Leu His Ala Gly Asp Gly 
             180                185                190
Ser Ser Asp Pro Glu Val Leu Leu Asn Ile Glu Asn Gln Arg Arg Gly 
         195                200                205
Gln Glu Leu Ser Ala Thr Arg Gln Ala His Asp Leu Ser Pro Ala Ala 
     210                215                220
Glu Ser Ser Ser Thr Phe Ser Phe Ser Gly Arg Asp Ser Ser Phe Thr 
 225                230                235                240
Glu Val Pro Arg Ser Pro Lys His Ala His Ser Ser Ser Leu Gln Gln 
                 245                250                255
Ala Ala Ser Arg Ser Pro Ser Phe Gly Asp Pro Gln Leu Ser Pro Glu 
             260                265                270
Ala Arg Pro Arg Cys Thr Ser His Ser Glu Thr Pro Thr Val Asp Asp 
         275                280                285
Glu Glu Lys Val Asp Glu Arg Ala Lys Leu Ser Val Ala Ala Lys Arg 
     290                295                300
Leu Leu Phe Arg Glu Met Glu Lys Ser Phe Asp Glu Gln Asn Val Pro 
 305                310                315                320
Lys Arg Arg Ser Arg Asn Thr Ala Val Glu Gln Arg Leu Arg Arg Leu 
                 325                330                335
Gln Asp Arg Ser Leu Thr Gln Pro Ile Thr Thr Glu Glu Val Val Ile 
             340                345                350
Ala Ala Thr Leu Gln Ala Ser Ala His Gln Lys Ala Leu Ala Lys Asp 
         355                360                365
Gln Thr Asn Glu Gly Lys Glu Leu Ala Glu Gln Gly Glu Pro Asp Ser 
     370                375                380
Ser Thr Leu Ser Leu Ala Glu Lys Leu Ala Leu Phe Asn Lys Leu Ser 
 385                390                395                400
Gln Pro Val Ser Lys Ala Ile Ser Thr Arg Asn Arg Ile Asp Thr Arg 
                 405                410                415
Gln Arg Arg Met Asn Ala Arg Tyr Gln Thr Gln Pro Val Thr Leu Gly 
             420                425                430
Glu Val Glu Gln Val Gln Ser Gly Lys Leu Ile Pro Phe Ser Pro Ala 
         435                440                445
Val Asn Thr Ser Val Ser Thr Val Ala Ser Thr Val Ala Pro Met Tyr 
     450                455                460
Ala Gly Asp Leu Arg Thr Lys Pro Pro Leu Asp His Asn Ala Ser Ala 
 465                470                475                480
Thr Asp Tyr Lys Phe Ser Ser Ser Ile Glu Asn Ser Asp Ser Pro Val 
                 485                490                495
Arg Ser Ile Leu Lys Ser Gln Ala Trp Gln Pro Leu Val Glu Gly Ser 
             500                505                510
Glu Asn Lys Gly Met Leu Arg Glu Tyr Gly Glu Thr Glu Ser Lys Arg 
         515                520                525
Ala Leu Thr Gly Arg Asp Ser Gly Met Glu Lys Tyr Gly Ser Phe Glu 
     530                535                540
Glu Ala Glu Ala Ser Tyr Pro Ile Leu Asn Arg Ala Arg Glu Gly Asp 
 545                550                555                560
Ser His Lys Glu Ser Lys Tyr Ala Val Pro Arg Arg Gly Ser Leu Glu 
                 565                570                575
Arg Ala Asn Pro Pro Ile Thr His Leu Gly Asp Glu Pro Lys Glu Phe 
             580                585                590
Ser Met Ala Lys Met Asn Ala Gln Gly Asn Leu Asp Leu Arg Asp Arg 
         595                600                605
Leu Pro Phe Glu Glu Lys Val Glu Val Glu Asn Val Met Lys Arg Lys 
     610                615                620
Phe Ser Leu Arg Ala Ala Glu Phe Gly Glu Pro Thr Ser Glu Gln Thr 
 625                630                635                640
Gly Thr Ala Ala Gly Lys Thr Ile Ala Gln Thr Thr Ala Pro Val Ser 
                 645                650                655
Trp Lys Pro Gln Asp Ser Ser Glu Gln Pro Gln Glu Lys Leu Cys Lys 
             660                665                670
Asn Pro Cys Ala Met Phe Ala Ala Gly Glu Ile Lys Thr Pro Thr Gly 
         675                680                685
Glu Gly Leu Leu Asp Ser Pro Ser Lys Thr Met Ser Ile Lys Glu Arg 
     690                695                700
Leu Ala Leu Leu Lys Lys Ser Gly Glu Glu Asp Trp Arg Asn Arg Leu 
 705                710                715                720
Ser Arg Arg Gln Glu Gly Gly Lys Ala Pro Ala Ser Ser Leu His Thr 
                 725                730                735
Gln Glu Ala Gly Arg Ser Leu Ile Lys Lys Arg Val Thr Glu Ser Arg 
             740                745                750
Glu Ser Gln Met Thr Ile Glu Glu Arg Lys Gln Leu Ile Thr Val Arg 
         755                760                765
Glu Glu Ala Trp Lys Thr Arg Gly Arg Gly Ala Ala Asn Asp Ser Thr 
     770                775                780
Gln Phe Thr Val Ala Gly Arg Met Val Lys Lys Gly Leu Ala Ser Pro 
 785                790                795                800
Thr Ala Ile Thr Pro Val Ala Ser Ala Ile Cys Gly Lys Thr Arg Gly 
                 805                810                815
Thr Thr Pro Val Ser Lys Pro Leu Glu Asp Ile Glu Ala Arg Pro Asp 
             820                825                830
Met Gln Leu Glu Ser Asp Leu Lys Leu Asp Arg Leu Glu Thr Phe Leu 
         835                840                845
Arg Arg Leu Asn Asn Lys Val Gly Gly Met His Glu Thr Val Leu Thr 
     850                855                860
Val Thr Gly Lys Ser Val Lys Glu Val Met Lys Pro Asp Asp Asp Glu 
 865                870                875                880
Thr Phe Ala Lys Phe Tyr Arg Ser Val Asp Tyr Asn Met Pro Arg Ser 
                 885                890                895
Pro Val Glu Met Asp Glu Asp Phe Asp Val Ile Phe Asp Pro Tyr Ala 
             900                905                910
Pro Lys Leu Thr Ser Ser Val Ala Glu His Lys Arg Ala Val Arg Pro 
         915                920                925
Lys Arg Arg Val Gln Ala Ser Lys Asn Pro Leu Lys Met Leu Ala Ala 
     930                935                940
Arg Glu Asp Leu Leu Gln Glu Tyr Thr Glu Gln Arg Leu Asn Val Ala 
 945                950                955                960
Phe Met Glu Ser Lys Arg Met Lys Val Glu Lys Met Ser Ser Asn Ser 
                 965                970                975
Asn Phe Ser Glu Val Thr Leu Ala Gly Leu Ala Ser Lys Glu Asn Phe 
             980                985                990
Ser Asn Val Ser Leu Arg Ser Val Asn Leu Thr Glu Gln Asn Ser Asn 
         995                1000                1005
Asn Ser Ala Val Pro Tyr Lys Arg Leu Met Leu Leu Gln Ile Lys Gly 
     1010                1015                1020
Arg Arg His Val Gln Thr Arg Leu Val Glu Pro Arg Ala Ser Ala Leu 
 1025                1030                1035                1040
Asn Ser Gly Asp Cys Phe Leu Leu Leu Ser Pro His Cys Cys Phe Leu 
                 1045                1050                1055
Trp Val Gly Glu Phe Ala Asn Val Ile Glu Lys Ala Lys Ala Ser Glu 
             1060                1065                1070
Leu Ala Thr Leu Ile Gln Thr Lys Arg Glu Leu Gly Cys Arg Ala Thr 
         1075                1080                1085
Tyr Ile Gln Thr Ile Glu Glu Gly Ile Asn Thr His Thr His Ala Ala 
     1090                1095                1100
Lys Asp Phe Trp Lys Leu Leu Gly Gly Gln Thr Ser Tyr Gln Ser Ala 
 1105                1110                1115                1120
Gly Asp Pro Lys Glu Asp Glu Leu Tyr Glu Ala Ala Ile Ile Glu Thr 
                 1125                1130                1135
Asn Cys Ile Tyr Arg Leu Met Asp Asp Lys Leu Val Pro Asp Asp Asp 
             1140                1145                1150
Tyr Trp Gly Lys Ile Pro Lys Cys Ser Leu Leu Gln Pro Lys Glu Val 
         1155                1160                1165
Leu Val Phe Asp Phe Gly Ser Glu Val Tyr Val Trp His Gly Lys Glu 
     1170                1175                1180
Val Thr Leu Ala Gln Arg Lys Ile Ala Phe Gln Leu Ala Lys His Leu 
 1185                1190                1195                1200
Trp Asn Gly Thr Phe Asp Tyr Glu Asn Cys Asp Ile Asn Pro Leu Asp 
                 1205                1210                1215
Pro Gly Glu Cys Asn Pro Leu Ile Pro Arg Lys Gly Gln Gly Arg Pro 
             1220                1225                1230
Asp Trp Ala Ile Phe Gly Arg Leu Thr Glu His Asn Glu Thr Ile Leu 
         1235                1240                1245
Phe Lys Glu Lys Phe Leu Asp Trp Thr Glu Leu Lys Arg Ser Asn Glu 
     1250                1255                1260
Lys Asn Pro Gly Glu Leu Ala Gln His Lys Glu Asp Pro Arg Thr Asp 
 1265                1270                1275                1280
Val Lys Ala Tyr Asp Val Thr Arg Met Val Ser Met Pro Gln Thr Thr 
                 1285                1290                1295
Ala Gly Thr Ile Leu Asp Gly Val Asn Val Gly Arg Gly Tyr Gly Leu 
             1300                1305                1310
Val Glu Gly His Asp Arg Arg Gln Phe Glu Ile Thr Ser Val Ser Val 
         1315                1320                1325
Asp Val Trp His Ile Leu Glu Phe Asp Tyr Ser Arg Leu Pro Lys Gln 
     1330                1335                1340
Ser Ile Gly Gln Phe His Glu Gly Asp Ala Tyr Val Val Lys Trp Lys 
 1345                1350                1355                1360
Phe Met Val Ser Thr Ala Val Gly Ser Arg Gln Lys Gly Glu His Ser 
                 1365                1370                1375
Val Arg Ala Ala Gly Lys Glu Lys Cys Val Tyr Phe Phe Trp Gln Gly 
             1380                1385                1390
Arg His Ser Thr Val Ser Glu Lys Gly Thr Ser Ala Leu Met Thr Val 
         1395                1400                1405
Glu Leu Asp Glu Glu Arg Gly Ala Gln Val Gln Val Leu Gln Gly Lys 
     1410                1415                1420
Glu Pro Pro Cys Phe Leu Gln Cys Phe Gln Gly Gly Met Val Val His 
 1425                1430                1435                1440
Ser Gly Arg Arg Glu Glu Glu Glu Glu Asn Val Gln Ser Glu Trp Arg 
                 1445                1450                1455
Leu Tyr Cys Val Arg Gly Glu Val Pro Val Glu Gly Asn Leu Leu Glu 
             1460                1465                1470
Val Ala Cys His Cys Ser Ser Leu Arg Ser Arg Thr Ser Met Val Val 
         1475                1480                1485
Leu Asn Val Asn Lys Ala Leu Ile Tyr Leu Trp His Gly Cys Lys Ala 
     1490                1495                1500
Gln Ala His Thr Lys Glu Val Gly Arg Thr Ala Ala Asn Lys Ile Lys 
 1505                1510                1515                1520
Glu Gln Cys Pro Leu Glu Ala Gly Leu His Ser Ser Ser Lys Val Thr 
                 1525                1530                1535
Ile His Glu Cys Asp Glu Gly Ser Glu Pro Leu Gly Phe Trp Asp Ala 
             1540                1545                1550
Leu Gly Arg Arg Asp Arg Lys Ala Tyr Asp Cys Met Leu Gln Asp Pro 
         1555                1560                1565
Gly Ser Phe Asn Phe Ala Pro Arg Leu Phe Ile Leu Ser Ser Ser Ser 
     1570                1575                1580
Gly Asp Phe Ala Ala Thr Glu Phe Val Tyr Pro Ala Arg Ala Pro Ser 
 1585                1590                1595                1600
Val Val Ser Ser Met Pro Phe Leu Gln Glu Asp Leu Tyr Ser Ala Pro 
                 1605                1610                1615
Gln Pro Ala Leu Phe Leu Val Asp Asn His His Glu Val Tyr Leu Trp 
             1620                1625                1630
Gln Gly Trp Trp Pro Ile Glu Asn Lys Ile Thr Gly Ser Ala Arg Ile 
         1635                1640                1645
Arg Trp Ala Ser Asp Arg Lys Ser Ala Met Glu Thr Val Leu Gln Tyr 
     1650                1655                1660
Cys Lys Gly Lys Asn Leu Lys Lys Pro Ala Pro Lys Ser Tyr Leu Ile 
 1665                1670                1675                1680
His Ala Gly Leu Glu Pro Leu Thr Phe Thr Asn Met Phe Pro Ser Trp 
                 1685                1690                1695
Glu His Arg Glu Asp Ile Ala Glu Ile Thr Glu Met Asp Thr Glu Val 
             1700                1705                1710
Ser Asn Gln Ile Thr Leu Val Glu Asp Val Leu Ala Lys Leu Cys Lys 
         1715                1720                1725
Thr Ile Tyr Pro Leu Ala Asp Leu Leu Ala Arg Pro Leu Pro Glu Gly 
     1730                1735                1740
Val Asp Pro Leu Lys Leu Glu Ile Tyr Leu Thr Asp Glu Asp Phe Glu 
 1745                1750                1755                1760
Phe Ala Leu Asp Met Thr Arg Asp Glu Tyr Asn Ala Leu Pro Ala Trp 
                 1765                1770                1775
Lys Gln Val Asn Leu Lys Lys Ala Lys Gly Leu Phe Ter 
             1780                1785



<210> 4717
<211> 552
<212> DNA
<213> Rattus norvegicus
<308> AA800735
<400> 4717

caatgtaaa  tgatcaatg  gttgtgatt  ctctgaaat  ttatttttg  gatcctgtg  60
cacaaaatg  cgtgtgtaa  gtttacaat  ggtatgaga  attgagatg  ttttatctc  120
actgagaat  aaactgtag  taaggttcc  agccggcat  aaaagagca  agcaaactt  180
tctgtatat  aactgtaca  aaaacaagg  actatacac  tccgggggg  acattaagg  240
agaaaggtt  attcagata  attcttcag  gtcacaccg  gaagtagta  aaagtcttt  300
ctcgcttta  caccggaag  agaactcgg  acaagccag  cctaaggct  aggaggcag  360
cctgagcct  ggagagact  gtggcaggc  taggtcaac  gaagtgaca  agccctaca  420
ttggtaatg  ccttttgac  ccaaaggga  cagttgcaa  tgaatgaat  catagcttg  480
taaatacat  gttgcttta  atggtgttt  tataaatat  tatatatat  tagaattca  540
aaactatca  aa  552



<210> 4718
<211> 6719
<212> DNA
<213> Homo sapiens
<308> AF051850
<400> 4718

tcggcggga  gcggcgatc  tgccaccgg  aggtgtgga  gagccgggt  gattctggc  60
acattggag  ttggttgct  tctaaaact  aaggagaag  ccatgaaga  atggtggat  120
ctcactgag  tttgactag  ggaagaaaa  agagagttc  agtggatgg  cttgaggac  180
tgaaaagct  agatatgat  attttgaag  catttcaca  cgaagccat  atttaaata  240
cggcgttaa  atttcaaca  gaaaaactt  agcttcctt  gattcccac  tcaaaggaa  300
gtttcaagc  ttcagaagg  gttctcact  gaagataaa  aacagctcg  taaccacga  360
agaggaatc  atgctcagc  tttagttgc  cttcctaaa  ttgcagaat  aagacaaat  420
tttgaacca  agaagaaag  attcttaga  atgaaaaga  aagaaagaa  tgccaggcg  480
ctggaaggg  ttgaaaatg  cactcagcc  atcctcttg  agagctgca  aggattggt  540
actcaccgc  tgctggagg  agacacccc  cgatacatg  gagccagcg  ccctgccag  600
ccccacatc  gccgatcaa  tgaagagga  gaaacttct  attcttctc  agaaaagca  660
actcgatcc  aatactgca  agaaacctc  ggtgtccac  gtgactcac  ctatggttc  720
ggtaccatg  acacccaca  tctggagtc  aaagccgaa  gaattgcaa  gtacaaagc  780
gaaagaagg  gacagctgg  agagaagta  gggctgact  tggatcccg  ggccgactc  840
gagtattta  cccgctata  caagtccag  aaggagcct  atgctgtcg  gaagcgggg  900
ggaaaaagt  acaaacagg  agagtcaag  agagatgcg  gttctctgt  ccccgggac  960
gagacgatg  ggctcagga  ctgtgccgg  gaatccaag  actatgccc  ccatgcggg  1020
gacggctct  ccgacccgg  ggtgctgct  aacatagaa  accaaagac  aggtcaaga  1080
ctgagtgcc  cccggcagg  ccatgacct  tccccagca  ccgagagtt  ctcgacctt  1140
tctttctct  ggcgagact  ctccttcac  gaagtgcca  ggtccccca  gcacgccca  1200
agctcctcc  tgcagcagg  agcctcccg  agcccctcc  ttggtgacc  acagctatc  1260
cctgaggcc  gacccaggt  cacttcaca  tcagaaacg  caactgtcg  tgatgaaga  1320
aaggtggat  aacgagcca  gctgagcgt  gccgccaag  ggttgcttt  cagggagat  1380
gaaaaatct  ttgatgaac  aaatgttcc  aagcgacgc  caagaaaca  agctgtgga  1440
cagaggcta  gccgtctgc  ggacaggtc  ctcacccag  ccatcacca  tgaagaggt  1500
gtcatcgca  ccacattgc  ggcctctgc  caccaaaag  ccttagcca  ggaccagac  1560
aatgagggc  aagagcttg  tgagcaagg  gaacctgat  cctccactc  aagcttggc  1620
gaaaagttg  ccttgttta  caaattgtc  cagccagtc  caaaagcga  ttctacccg  1680
aacagaata  acacgagac  gaggagaat  aacgctcgc  atcaaactc  gccagtcac  1740
ctgggagag  tggagcagg  gcagagtgg  aagctcatt  ctttctcac  tgccgtgaa  1800
acatcagtg  ctaccgtag  atccacggt  gctccaatg  atgccggag  tcttcgcac  1860
aagccacct  ttgaccaca  tgcaagtgc  actgactat  agttttctt  ttcaataga  1920
aattcggac  ctccagtta  aagcattct  aaatcgcaa  cttggcagc  tttggtaga  1980
ggtagcgag  acaagggaa  gttgagaga  tatggagag  cagaaagca  gagagcttt  2040
acaggtcga  acagtggga  ggagaagta  gggtccttt  aggaagcag  agcatccta  2100
cccatcctg  acagagcca  ggaaggaga  agccataag  aatctaaat  tgctgttcc  2160
agaagagga  gcctggaac  ggcgaaccc  cccatcacc  acctcgggg  tgaaccgaa  2220
gaattttcc  tggctaaaa  gaatgcaca  ggaaacttg  acttgaggg  caggctgcc  2280
tttgaagag  aggtggagg  ggagaatgt  atgaaaagg  agttttcac  aagagcggc  2340
gagttcggg  agcccactt  cgagcagac  gggacagct  ctgggaaaa  tattgctca  2400
accacagcc  ccgtgtcct  gaagcccca  gattcttcg  aacagccac  ggagaagct  2460
tgcaagaat  catgtgcga  gtttgctgc  ggagagatc  aaacgccga  aggggaggg  2520
cttcttgac  cacccagca  aaccatgtc  attaaagaa  gattggcac  gttgaagaa  2580
agcggggag  aagattgga  aaacagact  agcaggagg  aggagggcg  caaggcgcc  2640
gccagcagc  tgcacaccc  ggaagcagg  cggtccctc  tcaagaagc  ggtcacaga  2700
agtcgagag  gccaaatga  gattgagga  aggaagcag  tcatcactg  gagagagga  2760
gcctggaag  cgagaggca  aggagcggc  aacgactcg  cccagttca  tgtggctgg  2820
aggatggtg  agaaaggtt  ggcgtcacc  actgccata  ccccagtag  ctcagccat  2880
tgcggtaaa  caagaggca  cacacccgt  tccaaaccc  tggaagata  cgaagccag  2940
ccagatatg  agttagaat  ggacctgaa  ttggacagg  tggaaacct  tctaagaag  3000
ctgaataac  aagttggcg  gatgcacga  acggtgctc  ctgtcaccg  caaatctgt  3060
aaggaggtg  tgaagccag  tgatgatga  acctttgcc  aattttacc  cagcgtgga  3120
tataatatg  caagaagtc  tgtggagat  gatgaggac  tcgatgtca  tttcgatcc  3180
tatgcaccc  aattgacgt  ttccgtggc  gagcacaag  gggcagtta  gcccaagcg  3240
cgggttcag  cctccaaaa  ccccctgaa  atgctggcg  caagagaag  tctccttca  3300
gaatacact  agcagagat  aaacgttgc  ttcatggag  caaagcgga  gaaagtaga  3360
aagatgtct  ccaactcca  cttctcaga  gtcaccctg  cgggtttag  cagtaaaga  3420
aacttcagc  acgtcagcc  gcggagcgt  aacctgacg  aacagaact  taacaacag  3480
gccgtgccc  acaagaggc  gatgctgtt  cagattaaa  gaagaagac  tgtgcagac  3540
aggctggtg  aacctcgag  ttcggcgct  aacagtggg  actgcttcc  cctgctctc  3600
ccccactgc  gcttcctgt  ggtaggaga  tttgcaaac  tcatagaaa  ggcgaaggc  3660
tcagaactt  caactttaa  tcagacaaa  agggaactt  gttgtagag  tacttatat  3720
caaaccatt  aagaaggaa  taatacaca  actcatgca  ccaaagact  ctggaagct  3780
ctgggtggc  aaaccagtt  ccaatctgc  ggagaccca  aagaagatg  actctatga  3840
gcagccata  tagaaacta  ctgcattta  cgtctcatg  atgacaaac  tgttcctga  3900
gacgactac  gggggaaaa  tccgaagtg  tcccttctg  aacccaaag  ggtactggt  3960
tttgatttt  gtagtgaag  ttacgtatg  catgggaaa  aagtcacat  agcacaacg  4020
aaaatagca  ttcagctgg  aaagcactt  tggaatgga  cctttgact  tgagaactg  4080
gacatcaat  ccctggatc  tggagaatg  aatccgctt  tccccagaa  aggacaggg  4140
cggcccgac  gggcgatat  tgggagact  actgaacac  atgagacga  tttgttcaa  4200
gagaagttt  tggattgga  ggaactgaa  agatcgaat  agaagaacc  cggggaact  4260
gcccagcac  aggaagacc  caggactga  gtcaaggca  acgatgtga  acggatggt  4320
tccatgccc  agacgacag  aggcaccat  ctggacgga  tgaacgtcg  ccgtggcta  4380
ggcctggtg  aaggacacg  caggaggca  tttgagatc  ccagcgttt  cgtggatgt  4440
tggcacatc  tggaattcg  ctatagcag  ctccccaaa  aaagcatcg  gcagttcca  4500
gagggggat  cctatgtgg  caagtggaa  ttcatggtg  gcacggcag  gggaagtcg  4560
cagaaggga  agcactcgg  gagggcagc  ggcaaagag  agtgcgtct  cttcttctg  4620
caaggccgg  actccaccg  gagtgagaa  ggcacgtcg  cgctgatga  ggtggagct  4680
gacgaggaa  ggggggccc  ggtccaggt  ctccaggga  aggagcccc  ctgtttcct  4740
cagtgtttc  aggggggga  ggtggtgca  tcggggagg  gggaagagg  agaagaaaa  4800
gtgcaaagt  agtggcggc  gtactgcgt  cgtggagag  tgcccgtgg  agggaattt  4860
ctggaagtg  cctgtcact  tagcagcct  aggtccaga  cttccatgg  ggtgcttaa  4920
gtcaacaag  ccctcatct  cctgtggca  ggatgcaaa  cccaggccc  cacgaagga  4980
gtcggaagg  ccgctgcga  caagatcaa  gaacaatgt  ccctggaag  aggactgca  5040
agtagcagc  aagtcacaa  acacgagtg  gatgaaggc  ccgagccac  cggattctg  5100
gatgcctta  gaaggagag  caggaaagc  tacgattgc  tgcttcaag  tcctggaag  5160
tttaacttc  cgccccgcc  gttcatcct  agcagctcc  ctggggatt  tgcagccac  5220
gagtttgtg  accctgccc  agccccctc  gtggtcagt  ccatgccct  cctgcagga  5280
gatctgtac  gcgcgcccc  gccagcact  ttccttgtt  acaatcacc  cgaggtgta  5340
ctctggcaa  gctggtggc  catcgagaa  aagatcact  gttccgccc  catccgctg  5400
gcctccgac  ggaagagtg  gatggagac  gtgctccag  actgcaaag  aaaaaatct  5460
aagaaacca  cccccaagt  ttaccttat  cacgctggt  tggagcccc  gacattcac  5520
aatatgttt  ccagctggg  gcacagaga  gacatcgct  agatcacag  gatggacac  5580
gaagtttcc  atcagatca  cctcgtgga  gacgtctta  ccaagctct  taaaaccat  5640
tacccgctg  ccgacctcc  ggccaggcc  ctcccggag  gggtcgatc  tctgaagct  5700
gagatctat  tcaccgacg  agacttcga  tttgcacta  acatgacga  ggatgaata  5760
aacgccctg  ccgcctgga  gcaggtgaa  ctgaagaaa  caaaaggcc  gttctgagt  5820
gggagacgc  agaggagcc  cacggtcac  tccaacaac  ccactgcac  agggaaatg  5880
atatatatt  ttggactgg  gtttttcac  aagtatttt  caatcagag  tttcagaac  5940
tgacattgt  aaagatact  cttgtcccg  agttgtgta  tttgtaaat  ttcaaggga  6000
ctgtttgga  acttctttc  accattcag  aggttatca  aattaataa  agtatctgt  6060
atgtgcact  aagccgcag  tgctataga  agcactgcc  tcttgttcc  gctaggcaa  6120
gcctttttt  ttttttttg  agcagttct  tttataaag  gttattttg  tagtttgtg  6180
attctaaaa  atatatata  ttatataaa  accatataa  tcaaatatg  atttaacaa  6240
gcaatatgt  ttcattcac  ttcaagatt  gttttggtg  caaaataac  tgaaaaggt  6300
gatggagtt  cttctgttg  attagctct  ccaccaata  gtatcttca  acacgtttg  6360
aaatgtttc  tgcagcatt  ggtatgact  gttctgagt  ctgcttccg  tgctaaaat  6420
aacaaagaa  ttgtactta  tggcatgga  tctggagaa  ctatgcgaa  caacctttc  6480
accttaata  ctccccaaa  atgtatagt  ccttgtttt  atgtacagt  tatatacag  6540
aaagtttgc  ctgcatttt  gatgatggt  tggaacatt  tctacaatt  tactctcaa  6600
tagtcaaaa  aaaaacatc  caatttcta  taccggttg  aaacaaaca  tacacatgt  6660
attttgtga  ataggactc  caaataaaa  tatcagaat  aacacaaca  ttaactggt  6719



<210> 4719
<211> 1789
<212> PRT
<213> Homo sapiens
<308> AF051850
<400> 4719

Met Lys Arg Lys Glu Arg Ile Ala Arg Arg Leu Glu Gly Ile Glu Asn 
  1               5                  10                  15
Asp Thr Gln Pro Ile Leu Leu Gln Ser Cys Thr Gly Leu Val Thr His 
             20                  25                  30
Arg Leu Leu Glu Glu Asp Thr Pro Arg Tyr Met Arg Ala Ser Asp Pro 
         35                  40                  45
Ala Ser Pro His Ile Gly Arg Ser Asn Glu Glu Glu Glu Thr Ser Asp 
     50                  55                  60
Ser Ser Leu Glu Lys Gln Thr Arg Ser Lys Tyr Cys Thr Glu Thr Ser 
 65                  70                  75                  80
Gly Val His Gly Asp Ser Pro Tyr Gly Ser Gly Thr Met Asp Thr His 
                 85                  90                  95
Ser Leu Glu Ser Lys Ala Glu Arg Ile Ala Arg Tyr Lys Ala Glu Arg 
             100                105                110
Arg Arg Gln Leu Ala Glu Lys Tyr Gly Leu Thr Leu Asp Pro Glu Ala 
         115                120                125
Asp Ser Glu Tyr Leu Ser Arg Tyr Thr Lys Ser Arg Lys Glu Pro Asp 
     130                135                140
Ala Val Glu Lys Arg Gly Gly Lys Ser Asp Lys Gln Glu Glu Ser Ser 
 145                150                155                160
Arg Asp Ala Ser Ser Leu Tyr Pro Gly Thr Glu Thr Met Gly Leu Arg 
                 165                170                175
Thr Cys Ala Gly Glu Ser Lys Asp Tyr Ala Leu His Ala Gly Asp Gly 
             180                185                190
Ser Ser Asp Pro Glu Val Leu Leu Asn Ile Glu Asn Gln Arg Arg Gly 
         195                200                205
Gln Glu Leu Ser Ala Thr Arg Gln Ala His Asp Leu Ser Pro Ala Ala 
     210                215                220
Glu Ser Ser Ser Thr Phe Ser Phe Ser Gly Arg Asp Ser Ser Phe Thr 
 225                230                235                240
Glu Val Pro Arg Ser Pro Lys His Ala His Ser Ser Ser Leu Gln Gln 
                 245                250                255
Ala Ala Ser Arg Ser Pro Ser Phe Gly Asp Pro Gln Leu Ser Pro Glu 
             260                265                270
Ala Arg Pro Arg Cys Thr Ser His Ser Glu Thr Pro Thr Val Asp Asp 
         275                280                285
Glu Glu Lys Val Asp Glu Arg Ala Lys Leu Ser Val Ala Ala Lys Arg 
     290                295                300
Leu Leu Phe Arg Glu Met Glu Lys Ser Phe Asp Glu Gln Asn Val Pro 
 305                310                315                320
Lys Arg Arg Ser Arg Asn Thr Ala Val Glu Gln Arg Leu Arg Arg Leu 
                 325                330                335
Gln Asp Arg Ser Leu Thr Gln Pro Ile Thr Thr Glu Glu Val Val Ile 
             340                345                350
Ala Ala Thr Leu Gln Ala Ser Ala His Gln Lys Ala Leu Ala Lys Asp 
         355                360                365
Gln Thr Asn Glu Gly Lys Glu Leu Ala Glu Gln Gly Glu Pro Asp Ser 
     370                375                380
Ser Thr Leu Ser Leu Ala Glu Lys Leu Ala Leu Phe Asn Lys Leu Ser 
 385                390                395                400
Gln Pro Val Ser Lys Ala Ile Ser Thr Arg Asn Arg Ile Asp Thr Arg 
                 405                410                415
Gln Arg Arg Met Asn Ala Arg Tyr Gln Thr Gln Pro Val Thr Leu Gly 
             420                425                430
Glu Val Glu Gln Val Gln Ser Gly Lys Leu Ile Pro Phe Ser Pro Ala 
         435                440                445
Val Asn Thr Ser Val Ser Thr Val Ala Ser Thr Val Ala Pro Met Tyr 
     450                455                460
Ala Gly Asp Leu Arg Thr Lys Pro Pro Leu Asp His Asn Ala Ser Ala 
 465                470                475                480
Thr Asp Tyr Lys Phe Ser Ser Ser Ile Glu Asn Ser Asp Ser Pro Val 
                 485                490                495
Arg Ser Ile Leu Lys Ser Gln Ala Trp Gln Pro Leu Val Glu Gly Ser 
             500                505                510
Glu Asn Lys Gly Met Leu Arg Glu Tyr Gly Glu Thr Glu Ser Lys Arg 
         515                520                525
Ala Leu Thr Gly Arg Asp Ser Gly Met Glu Lys Tyr Gly Ser Phe Glu 
     530                535                540
Glu Ala Glu Ala Ser Tyr Pro Ile Leu Asn Arg Ala Arg Glu Gly Asp 
 545                550                555                560
Ser His Lys Glu Ser Lys Tyr Ala Val Pro Arg Arg Gly Ser Leu Glu 
                 565                570                575
Arg Ala Asn Pro Pro Ile Thr His Leu Gly Asp Glu Pro Lys Glu Phe 
             580                585                590
Ser Met Ala Lys Met Asn Ala Gln Gly Asn Leu Asp Leu Arg Asp Arg 
         595                600                605
Leu Pro Phe Glu Glu Lys Val Glu Val Glu Asn Val Met Lys Arg Lys 
     610                615                620
Phe Ser Leu Arg Ala Ala Glu Phe Gly Glu Pro Thr Ser Glu Gln Thr 
 625                630                635                640
Gly Thr Ala Ala Gly Lys Thr Ile Ala Gln Thr Thr Ala Pro Val Ser 
                 645                650                655
Trp Lys Pro Gln Asp Ser Ser Glu Gln Pro Gln Glu Lys Leu Cys Lys 
             660                665                670
Asn Pro Cys Ala Met Phe Ala Ala Gly Glu Ile Lys Thr Pro Thr Gly 
         675                680                685
Glu Gly Leu Leu Asp Ser Pro Ser Lys Thr Met Ser Ile Lys Glu Arg 
     690                695                700
Leu Ala Leu Leu Lys Lys Ser Gly Glu Glu Asp Trp Arg Asn Arg Leu 
 705                710                715                720
Ser Arg Arg Gln Glu Gly Gly Lys Ala Pro Ala Ser Ser Leu His Thr 
                 725                730                735
Gln Glu Ala Gly Arg Ser Leu Ile Lys Lys Arg Val Thr Glu Ser Arg 
             740                745                750
Glu Ser Gln Met Thr Ile Glu Glu Arg Lys Gln Leu Ile Thr Val Arg 
         755                760                765
Glu Glu Ala Trp Lys Thr Arg Gly Arg Gly Ala Ala Asn Asp Ser Thr 
     770                775                780
Gln Phe Thr Val Ala Gly Arg Met Val Lys Lys Gly Leu Ala Ser Pro 
 785                790                795                800
Thr Ala Ile Thr Pro Val Ala Ser Ala Ile Cys Gly Lys Thr Arg Gly 
                 805                810                815
Thr Thr Pro Val Ser Lys Pro Leu Glu Asp Ile Glu Ala Arg Pro Asp 
             820                825                830
Met Gln Leu Glu Ser Asp Leu Lys Leu Asp Arg Leu Glu Thr Phe Leu 
         835                840                845
Arg Arg Leu Asn Asn Lys Val Gly Gly Met His Glu Thr Val Leu Thr 
     850                855                860
Val Thr Gly Lys Ser Val Lys Glu Val Met Lys Pro Asp Asp Asp Glu 
 865                870                875                880
Thr Phe Ala Lys Phe Tyr Arg Ser Val Asp Tyr Asn Met Pro Arg Ser 
                 885                890                895
Pro Val Glu Met Asp Glu Asp Phe Asp Val Ile Phe Asp Pro Tyr Ala 
             900                905                910
Pro Lys Leu Thr Ser Ser Val Ala Glu His Lys Arg Ala Val Arg Pro 
         915                920                925
Lys Arg Arg Val Gln Ala Ser Lys Asn Pro Leu Lys Met Leu Ala Ala 
     930                935                940
Arg Glu Asp Leu Leu Gln Glu Tyr Thr Glu Gln Arg Leu Asn Val Ala 
 945                950                955                960
Phe Met Glu Ser Lys Arg Met Lys Val Glu Lys Met Ser Ser Asn Ser 
                 965                970                975
Asn Phe Ser Glu Val Thr Leu Ala Gly Leu Ala Ser Lys Glu Asn Phe 
             980                985                990
Ser Asn Val Ser Leu Arg Ser Val Asn Leu Thr Glu Gln Asn Ser Asn 
         995                1000                1005
Asn Ser Ala Val Pro Tyr Lys Arg Leu Met Leu Leu Gln Ile Lys Gly 
     1010                1015                1020
Arg Arg His Val Gln Thr Arg Leu Val Glu Pro Arg Ala Ser Ala Leu 
 1025                1030                1035                1040
Asn Ser Gly Asp Cys Phe Leu Leu Leu Ser Pro His Cys Cys Phe Leu 
                 1045                1050                1055
Trp Val Gly Glu Phe Ala Asn Val Ile Glu Lys Ala Lys Ala Ser Glu 
             1060                1065                1070
Leu Ala Thr Leu Ile Gln Thr Lys Arg Glu Leu Gly Cys Arg Ala Thr 
         1075                1080                1085
Tyr Ile Gln Thr Ile Glu Glu Gly Ile Asn Thr His Thr His Ala Ala 
     1090                1095                1100
Lys Asp Phe Trp Lys Leu Leu Gly Gly Gln Thr Ser Tyr Gln Ser Ala 
 1105                1110                1115                1120
Gly Asp Pro Lys Glu Asp Glu Leu Tyr Glu Ala Ala Ile Ile Glu Thr 
                 1125                1130                1135
Asn Cys Ile Tyr Arg Leu Met Asp Asp Lys Leu Val Pro Asp Asp Asp 
             1140                1145                1150
Tyr Trp Gly Lys Ile Pro Lys Cys Ser Leu Leu Gln Pro Lys Glu Val 
         1155                1160                1165
Leu Val Phe Asp Phe Gly Ser Glu Val Tyr Val Trp His Gly Lys Glu 
     1170                1175                1180
Val Thr Leu Ala Gln Arg Lys Ile Ala Phe Gln Leu Ala Lys His Leu 
 1185                1190                1195                1200
Trp Asn Gly Thr Phe Asp Tyr Glu Asn Cys Asp Ile Asn Pro Leu Asp 
                 1205                1210                1215
Pro Gly Glu Cys Asn Pro Leu Ile Pro Arg Lys Gly Gln Gly Arg Pro 
             1220                1225                1230
Asp Trp Ala Ile Phe Gly Arg Leu Thr Glu His Asn Glu Thr Ile Leu 
         1235                1240                1245
Phe Lys Glu Lys Phe Leu Asp Trp Thr Glu Leu Lys Arg Ser Asn Glu 
     1250                1255                1260
Lys Asn Pro Gly Glu Leu Ala Gln His Lys Glu Asp Pro Arg Thr Asp 
 1265                1270                1275                1280
Val Lys Ala Tyr Asp Val Thr Arg Met Val Ser Met Pro Gln Thr Thr 
                 1285                1290                1295
Ala Gly Thr Ile Leu Asp Gly Val Asn Val Gly Arg Gly Tyr Gly Leu 
             1300                1305                1310
Val Glu Gly His Asp Arg Arg Gln Phe Glu Ile Thr Ser Val Ser Val 
         1315                1320                1325
Asp Val Trp His Ile Leu Glu Phe Asp Tyr Ser Arg Leu Pro Lys Gln 
     1330                1335                1340
Ser Ile Gly Gln Phe His Glu Gly Asp Ala Tyr Val Val Lys Trp Lys 
 1345                1350                1355                1360
Phe Met Val Ser Thr Ala Val Gly Ser Arg Gln Lys Gly Glu His Ser 
                 1365                1370                1375
Val Arg Ala Ala Gly Lys Glu Lys Cys Val Tyr Phe Phe Trp Gln Gly 
             1380                1385                1390
Arg His Ser Thr Val Ser Glu Lys Gly Thr Ser Ala Leu Met Thr Val 
         1395                1400                1405
Glu Leu Asp Glu Glu Arg Gly Ala Gln Val Gln Val Leu Gln Gly Lys 
     1410                1415                1420
Glu Pro Pro Cys Phe Leu Gln Cys Phe Gln Gly Gly Met Val Val His 
 1425                1430                1435                1440
Ser Gly Arg Arg Glu Glu Glu Glu Glu Asn Val Gln Ser Glu Trp Arg 
                 1445                1450                1455
Leu Tyr Cys Val Arg Gly Glu Val Pro Val Glu Gly Asn Leu Leu Glu 
             1460                1465                1470
Val Ala Cys His Cys Ser Ser Leu Arg Ser Arg Thr Ser Met Val Val 
         1475                1480                1485
Leu Asn Val Asn Lys Ala Leu Ile Tyr Leu Trp His Gly Cys Lys Ala 
     1490                1495                1500
Gln Ala His Thr Lys Glu Val Gly Arg Thr Ala Ala Asn Lys Ile Lys 
 1505                1510                1515                1520
Glu Gln Cys Pro Leu Glu Ala Gly Leu His Ser Ser Ser Lys Val Thr 
                 1525                1530                1535
Ile His Glu Cys Asp Glu Gly Ser Glu Pro Leu Gly Phe Trp Asp Ala 
             1540                1545                1550
Leu Gly Arg Arg Asp Arg Lys Ala Tyr Asp Cys Met Leu Gln Asp Pro 
         1555                1560                1565
Gly Ser Phe Asn Phe Ala Pro Arg Leu Phe Ile Leu Ser Ser Ser Ser 
     1570                1575                1580
Gly Asp Phe Ala Ala Thr Glu Phe Val Tyr Pro Ala Arg Ala Pro Ser 
 1585                1590                1595                1600
Val Val Ser Ser Met Pro Phe Leu Gln Glu Asp Leu Tyr Ser Ala Pro 
                 1605                1610                1615
Gln Pro Ala Leu Phe Leu Val Asp Asn His His Glu Val Tyr Leu Trp 
             1620                1625                1630
Gln Gly Trp Trp Pro Ile Glu Asn Lys Ile Thr Gly Ser Ala Arg Ile 
         1635                1640                1645
Arg Trp Ala Ser Asp Arg Lys Ser Ala Met Glu Thr Val Leu Gln Tyr 
     1650                1655                1660
Cys Lys Gly Lys Asn Leu Lys Lys Pro Ala Pro Lys Ser Tyr Leu Ile 
 1665                1670                1675                1680
His Ala Gly Leu Glu Pro Leu Thr Phe Thr Asn Met Phe Pro Ser Trp 
                 1685                1690                1695
Glu His Arg Glu Asp Ile Ala Glu Ile Thr Glu Met Asp Thr Glu Val 
             1700                1705                1710
Ser Asn Gln Ile Thr Leu Val Glu Asp Val Leu Ala Lys Leu Cys Lys 
         1715                1720                1725
Thr Ile Tyr Pro Leu Ala Asp Leu Leu Ala Arg Pro Leu Pro Glu Gly 
     1730                1735                1740
Val Asp Pro Leu Lys Leu Glu Ile Tyr Leu Thr Asp Glu Asp Phe Glu 
 1745                1750                1755                1760
Phe Ala Leu Asp Met Thr Arg Asp Glu Tyr Asn Ala Leu Pro Ala Trp 
                 1765                1770                1775
Lys Gln Val Asn Leu Lys Lys Ala Lys Gly Leu Phe Ter 
             1780                1785



<210> 4720
<211> 637
<212> DNA
<213> Rattus norvegicus
<308> AA800749
<400> 4720

aagcaccaa  agtacacag  aatggttgg  acataaaaa  cacaattat  gatataatt  60
cttaccatc  agtttacaa  ctaaaataa  acacaagaa  attgtcagc  cacatcaaa  120
tttccttat  ttggaattg  ctactttgg  aaatgaatg  ggcaaaatg  cctatttca  180
gcaaagtat  aataaggct  tgaatatga  acacaaaat  ttttttgtg  atccatttt  240
catgttaca  tatggtaac  aaggacaaa  agggcactt  gaaatttca  aagcacaat  300
aattacttc  gattgttct  agaaactca  agatgttca  tgacaaatg  cagcagcca  360
tgaaagcct  caattaata  gaactagat  aagtctttg  cttggcccc  tttagacct  420
catctcctt  cttactaag  gctctaatg  tatacccca  agtgaaagg  accatctct  480
gatgaatta  tacataatt  tgagatcaa  cttactgga  tattgtcta  agagaagtg  540
gcaaagcca  cagtgggga  tctggctaa  tgatgtcac  caagcaaag  cagtcaggc  600
aggccacgc  catctaaag  gattgggaa  gcacagg  637



<210> 4721
<211> 475
<212> DNA
<213> Rattus norvegicus
<308> AA800753
<400> 4721

agacaacag  atgtagtag  tttgaatcc  ctgagatgt  gctttcaat  tgaaatatt  60
tgtatacat  tatataaaa  ataatccaa  gtatgactc  tctgacaga  gtttaagat  120
aataaagtt  ttgaacatg  atttaggaa  agaggggag  agcccaccc  gctaccctg  180
tgttgctgg  ttatttctg  agtggtctc  atagtggtt  ttagaggga  ccatgtgcc  240
tcagtcttc  gagttacga  aagatacca  aatcaagac  ggaggggaa  tggggaatg  300
gcaggtatt  atcttaaat  cattttgca  tctatctgg  acaagataa  aacaggtta  360
tggggatag  tattaatta  gaataaatt  cagtcagat  aagacataa  tgccgaatt  420
agtttttaa  agactgcat  tatagatgt  tagccatac  ctagatcaa  tcttt  475



<210> 4722
<211> 1039
<212> PRT
<213> Rattus norvegicus
<308> CAC17143
<400> 4722

Met Asp Pro Asn Thr Ile Ile Glu Ala Leu Arg Gly Thr Met Asp Pro 
  1               5                  10                  15
Ala Leu Arg Glu Ala Ala Glu Arg Gln Leu Asn Glu Ala His Lys Ser 
             20                  25                  30
Leu Asn Phe Val Ser Thr Leu Leu Gln Ile Thr Met Ser Glu Gln Leu 
         35                  40                  45
Asp Leu Pro Val Arg Gln Ala Gly Val Ile Tyr Leu Lys Asn Met Ile 
     50                  55                  60
Thr Gln Tyr Trp Pro Asp Arg Glu Ala Thr Pro Gly Asp Ile Ala Pro 
 65                  70                  75                  80
Tyr Thr Ile Pro Glu Glu Asp Arg His Cys Ile Arg Glu Asn Ile Val 
                 85                  90                  95
Glu Ala Ile Ile His Ser Pro Glu Leu Ile Arg Val Gln Leu Thr Thr 
             100                105                110
Cys Ile His His Ile Ile Lys His Asp Tyr Pro Ser Arg Trp Thr Ala 
         115                120                125
Ile Val Asp Lys Ile Gly Phe Tyr Leu Gln Ser Asp Asn Ser Ala Cys 
     130                135                140
Trp Leu Gly Ile Leu Leu Cys Leu Tyr Gln Leu Val Lys Asn Tyr Glu 
 145                150                155                160
Tyr Lys Lys Pro Glu Glu Arg Ser Pro Leu Val Ala Ala Met Gln His 
                 165                170                175
Phe Leu Pro Val Leu Lys Asp Arg Phe Ile Gln Leu Leu Ser Asp Gln 
             180                185                190
Ser Asp Gln Ser Val Leu Ile Gln Lys Gln Ile Phe Lys Ile Phe Tyr 
         195                200                205
Ala Leu Val Gln Tyr Thr Leu Pro Leu Glu Leu Ile Asn Gln Gln Asn 
     210                215                220
Leu Thr Glu Trp Val Glu Ile Leu Lys Thr Val Val Asn Arg Asp Val 
 225                230                235                240
Pro Asn Glu Thr Leu Gln Val Glu Glu Asp Asp Arg Pro Glu Leu Pro 
                 245                250                255
Trp Trp Lys Cys Lys Lys Trp Ala Leu His Ile Leu Ala Arg Leu Phe 
             260                265                270
Glu Arg Tyr Gly Ser Pro Gly Asn Val Ser Lys Glu Tyr Asn Glu Phe 
         275                280                285
Ala Glu Val Phe Leu Lys Ala Phe Ala Val Gly Val Gln Gln Val Leu 
     290                295                300
Leu Lys Val Leu Tyr Gln Tyr Lys Glu Lys Gln Tyr Met Ala Pro Arg 
 305                310                315                320
Val Leu Gln Gln Thr Leu Asn Tyr Ile Asn Gln Gly Val Ser His Ala 
                 325                330                335
Leu Thr Trp Lys Asn Leu Lys Pro His Ile Gln Gly Ile Ile Gln Asp 
             340                345                350
Val Ile Phe Pro Leu Met Cys Tyr Thr Asp Ala Asp Glu Glu Leu Trp 
         355                360                365
Gln Glu Asp Pro Tyr Glu Tyr Ile Arg Met Lys Phe Asp Val Phe Glu 
     370                375                380
Asp Phe Ile Ser Pro Thr Thr Ala Ala Gln Thr Leu Leu Phe Thr Ala 
 385                390                395                400
Cys Ser Lys Arg Lys Glu Val Val Leu Gln Lys Thr Met Gly Phe Cys 
                 405                410                415
Tyr Gln Ile Leu Thr Glu Pro Asn Ala Asp Pro Arg Lys Lys Asp Gly 
             420                425                430
Ala Leu His Met Ile Gly Ser Leu Ala Glu Ile Leu Leu Lys Lys Lys 
         435                440                445
Ile Tyr Lys Asp Gln Met Glu Tyr Met Leu Gln Asn His Val Phe Pro 
     450                455                460
Leu Phe Ser Ser Glu Leu Gly Tyr Met Arg Ala Arg Ala Cys Trp Val 
 465                470                475                480
Leu His Tyr Phe Cys Glu Val Lys Phe Lys Ser Asp Gln Asn Leu Gln 
                 485                490                495
Thr Ala Leu Glu Leu Thr Arg Arg Cys Leu Ile Asp Asp Arg Glu Met 
             500                505                510
Pro Val Lys Val Glu Ala Ala Ile Ala Leu Gln Val Leu Ile Ser Asn 
         515                520                525
Gln Glu Lys Ala Lys Glu Tyr Ile Thr Pro Phe Ile Arg Pro Val Met 
     530                535                540
Gln Ala Leu Leu His Ile Ile Arg Glu Thr Glu Asn Asp Asp Leu Thr 
 545                550                555                560
Asn Val Ile Gln Lys Met Ile Cys Glu Tyr Ser Glu Glu Val Thr Pro 
                 565                570                575
Ile Ala Val Glu Met Thr Gln His Leu Ala Met Thr Phe Asn Gln Val 
             580                585                590
Ile Gln Thr Gly Pro Asp Glu Glu Gly Ser Asp Asp Lys Ala Val Thr 
         595                600                605
Ala Met Gly Ile Leu Asn Thr Ile Asp Thr Leu Leu Ser Val Val Glu 
     610                615                620
Asp His Lys Glu Ile Thr Gln Gln Leu Glu Gly Ile Cys Leu Gln Val 
 625                630                635                640
Ile Gly Thr Val Leu Gln Gln His Val Leu Glu Phe Tyr Glu Glu Ile 
                 645                650                655
Phe Ser Leu Ala His Ser Leu Thr Cys Gln Gln Val Ser Pro Gln Met 
             660                665                670
Trp Gln Leu Leu Pro Leu Val Phe Glu Val Phe Gln Gln Asp Gly Phe 
         675                680                685
Asp Tyr Phe Thr Asp Met Met Pro Leu Leu His Asn Tyr Val Thr Val 
     690                695                700
Asp Thr Asp Thr Leu Leu Ser Asp Thr Lys Tyr Leu Glu Met Ile Tyr 
 705                710                715                720
Ser Met Cys Lys Lys Val Leu Thr Gly Val Ala Gly Glu Asp Ala Glu 
                 725                730                735
Cys His Ala Ala Lys Leu Leu Glu Val Ile Ile Leu Gln Cys Lys Gly 
             740                745                750
Arg Gly Ile Asp Gln Cys Ile Pro Leu Phe Val Glu Ala Ala Leu Glu 
         755                760                765
Arg Leu Thr Arg Glu Val Lys Thr Ser Glu Leu Arg Thr Met Cys Leu 
     770                775                780
Gln Val Ala Ile Ala Ala Leu Tyr Tyr Asn Pro His Leu Leu Leu Asn 
 785                790                795                800
Thr Leu Glu Asn Leu Arg Phe Pro Asn Asn Val Glu Pro Val Thr Asn 
                 805                810                815
His Phe Ile Thr Gln Trp Leu Asn Asp Val Asp Cys Phe Leu Gly Leu 
             820                825                830
His Asp Arg Lys Met Cys Val Leu Gly Leu Cys Ala Leu Ile Asp Met 
         835                840                845
Glu Gln Ile Pro Gln Val Leu Asn Gln Val Ser Gly Gln Ile Leu Pro 
     850                855                860
Ala Phe Ile Leu Leu Phe Asn Gly Leu Lys Arg Ala Tyr Ala Cys His 
 865                870                875                880
Ala Glu His Glu Asn Asp Ser Asp Asp Asp Glu Asp Ala Glu Asp Asp 
                 885                890                895
Asp Glu Thr Glu Glu Leu Gly Ser Asp Glu Asp Asp Ile Asp Glu Asp 
             900                905                910
Gly Gln Glu Tyr Leu Glu Ile Leu Ala Lys Gln Ala Gly Glu Asp Gly 
         915                920                925
Asp Asp Glu Asp Trp Glu Glu Asp Asp Ala Glu Glu Thr Ala Leu Glu 
     930                935                940
Gly Tyr Ser Thr Ile Ile Asp Asp Glu Asp Asn Pro Val Asp Glu Tyr 
 945                950                955                960
Gln Ile Phe Lys Ala Ile Phe Gln Thr Ile Gln Asn Arg Asn Pro Val 
                 965                970                975
Trp Tyr Gln Ala Leu Thr His Gly Leu Asn Glu Glu Gln Arg Lys Gln 
             980                985                990
Leu Gln Asp Ile Ala Thr Leu Ala Asp Gln Arg Arg Ala Ala His Glu 
         995                1000                1005
Ser Lys Met Ile Glu Lys His Gly Gly Tyr Lys Phe Ser Ala Pro Val 
     1010                1015                1020
Val Pro Ser Ser Phe Asn Phe Gly Gly Pro Ala Pro Gly Met Asn 
 1025                1030                1035



<210> 4723
<211> 2291
<212> DNA
<213> Homo sapiens
<308> AK027892
<400> 4723

ataatccac  cctactact  aatacctca  aaaatcttc  cttccctaa  aatgttgaa  60
cagttacaa  tcattttat  acacagtgg  ttaatgatg  tgactgttt  ttggggctt  120
atgacagaa  gatgtgtgt  ctcggactc  gtgctctta  tgatatgga  cagataccc  180
aagttttaa  tcaggtttc  ggacagatt  tgccggctt  tatcctttt  tttaacgga  240
tgaaaagag  atatgcctg  catgcagaa  atgagaatg  cagtgatga  gatgatgaa  300
ctgaagatg  tgatgaaac  gaggaactg  ggagtgatg  agatgatat  gatgaagat  360
ggcaagaat  tttggagat  ctggctaag  aggctggtg  agatggaga  gatgaagat  420
gggaagaag  tgatgctga  gagactgct  tggaaggct  ttccacaat  attgatgat  480
aagataacc  tgttgatga  tatcagata  ttaaagcta  ctttcaaac  attcaaaat  540
gtaatcctg  gtggtatca  gcgctgact  acggtctta  tgaagaaca  agaaaacag  600
tacaggaca  agcaactct  gctgatcaa  gaagagcag  ccatgaatc  aaaatgatt  660
agaagcatg  aggatacaa  ttcagtgct  cagttgtgc  aagttcttt  aattttgga  720
gcccagcac  agggatgaa  tgagttatc  ctttctttc  tgctgtgtg  ttgtagtga  780
gagcttgtg  tcctcctag  agtggttcc  gaactggtt  atgttatct  ttctaaact  840
ataatcaat  gatggacaa  agaaacaac  accccagga  atgggacct  atcatgcaa  900
ctggcactg  aaaagaaat  agcgggatt  tgggggtgg  ggggatggg  ggtacctta  960
agggagtat  ttctttatt  tttgaagaa  gtaagatcc  gactctgaa  cttcaaagt  1020
acactgtgg  aatctgaaa  gaggggatg  catgaaggc  gcttttctt  ttctgagga  1080
aaaataggc  tgggctaca  gactattta  aatgtctca  ttacagtat  aaactcaaa  1140
gtagatgta  tttttacac  tatgagtat  tgtccaatt  ctgtctctt  ctcaccatt  1200
ggtatctat  ctttatatg  aaataagat  aggtcatct  atagcctta  tcagtcttc  1260
tcattttca  cattgttcc  atgtagatt  ttggacatt  attgtagca  tacataact  1320
attataaaa  tctgtaaat  aattagcac  ttcatattg  aacaagcct  ctagcctat  1380
tataaaata  caaaatgtt  gctgtttat  aaaagatgt  atggggtgg  gggcagggg  1440
aatttcaag  tattaattt  aaaatgaac  agcaatttt  tacctggtg  ctttgtggt  1500
cactcacct  tgatagtga  ttgaattcg  tatgtaaaa  ggggttagt  gtatttcat  1560
gctgctaaa  atgacaact  cctctgtgt  ctgtttttc  taaagctgt  agtgtacaa  1620
tgggtattt  aataccaga  cttactgta  aaaataaaa  aggtggtat  tagagcatg  1680
aaattggat  taaagttct  ctcttaaag  gttgatcta  gagtatggc  aaacatcta  1740
atatgcaat  tattaaaag  acttaattc  gctattatg  cttgatttg  ttgcagttt  1800
ttcctaatt  taacaaatt  ttcctcatt  gcctgtttt  aatcctgtg  ctagaagga  1860
tacaaaatg  acactttac  aaattgata  ttaacactt  cccactccc  tttccccat  1920
tcttctacc  ctcttgttg  tcgtggtat  tgatcttga  tagataggc  gaaggcaca  1980
ggttccctc  aaaaaccac  attgatacc  ctacaaaaa  aagccagca  aaagatact  2040
tagagaggt  ggcttgctt  cctctcttc  taactgcat  ttgaaaaat  agccgttat  2100
gatcttaaa  atcggtcag  tgagtcata  attgggtta  tttttatat  catgtatac  2160
caaaatatt  caaattgaa  gcaacatct  aatggattc  aaactatta  aagctgttg  2220
ctaaaacag  tgagaaaaa  atttataac  gtaaaaaca  atgcacata  tgatattta  2280
aatgcgtaa  t  2291



<210> 4724
<211> 1010
<212> PRT
<213> Homo sapiens
<308> CAC17609
<400> 4724

Ala His Lys Ser Leu Asn Phe Val Ser Thr Leu Leu Gln Ile Thr Met 
  1               5                  10                  15
Ser Glu Gln Leu Asp Leu Pro Val Arg Gln Ala Gly Val Ile Tyr Leu 
             20                  25                  30
Lys Asn Met Ile Thr Gln Tyr Trp Pro Asp Arg Glu Thr Ala Pro Gly 
         35                  40                  45
Asp Ile Ser Pro Tyr Thr Ile Pro Glu Glu Asp Arg His Cys Ile Arg 
     50                  55                  60
Glu Asn Ile Val Glu Ala Ile Ile His Ser Pro Glu Leu Ile Arg Val 
 65                  70                  75                  80
Gln Leu Thr Thr Cys Ile His His Ile Ile Lys His Asp Tyr Pro Ser 
                 85                  90                  95
Arg Trp Thr Ala Ile Val Asp Lys Ile Gly Phe Tyr Leu Gln Ser Asp 
             100                105                110
Asn Ser Ala Cys Trp Leu Gly Ile Leu Leu Cys Leu Tyr Gln Leu Val 
         115                120                125
Lys Asn Tyr Glu Tyr Lys Lys Pro Glu Glu Arg Ser Pro Leu Val Ala 
     130                135                140
Ala Met Gln His Phe Leu Pro Val Leu Lys Asp Arg Phe Ile Gln Leu 
 145                150                155                160
Leu Ser Asp Gln Ser Asp Gln Ser Val Leu Ile Gln Lys Gln Ile Phe 
                 165                170                175
Lys Ile Phe Tyr Ala Leu Val Gln Tyr Thr Leu Pro Leu Glu Leu Ile 
             180                185                190
Asn Gln Gln Asn Leu Thr Glu Trp Ile Glu Ile Leu Lys Thr Val Val 
         195                200                205
Asn Arg Asp Val Pro Asn Glu Thr Leu Gln Val Glu Glu Asp Asp Arg 
     210                215                220
Pro Glu Leu Pro Trp Trp Lys Cys Lys Lys Trp Ala Leu His Ile Leu 
 225                230                235                240
Ala Arg Leu Phe Glu Arg Tyr Gly Ser Pro Gly Asn Val Ser Lys Glu 
                 245                250                255
Tyr Asn Glu Phe Ala Glu Val Phe Leu Lys Ala Phe Ala Val Gly Val 
             260                265                270
Gln Gln Val Leu Leu Lys Val Leu Tyr Gln Tyr Lys Glu Lys Gln Tyr 
         275                280                285
Met Ala Pro Arg Val Leu Gln Gln Thr Leu Asn Tyr Ile Asn Gln Gly 
     290                295                300
Val Ser His Ala Leu Thr Trp Lys Asn Leu Lys Pro His Ile Gln Gly 
 305                310                315                320
Ile Ile Gln Asp Val Ile Phe Pro Leu Met Cys Tyr Thr Asp Ala Asp 
                 325                330                335
Glu Glu Leu Trp Gln Glu Asp Pro Tyr Glu Tyr Ile Arg Met Lys Phe 
             340                345                350
Asp Val Phe Glu Asp Phe Ile Ser Pro Thr Thr Ala Ala Gln Thr Leu 
         355                360                365
Leu Phe Thr Ala Cys Ser Lys Arg Lys Glu Val Leu Gln Lys Thr Met 
     370                375                380
Gly Phe Cys Tyr Gln Ile Leu Thr Glu Pro Asn Ala Asp Pro Arg Lys 
 385                390                395                400
Lys Asp Gly Ala Leu His Met Ile Gly Ser Leu Ala Glu Ile Leu Leu 
                 405                410                415
Lys Lys Lys Ile Tyr Lys Asp Gln Met Glu Tyr Met Leu Gln Asn His 
             420                425                430
Val Phe Pro Leu Phe Ser Ser Glu Leu Gly Tyr Met Arg Ala Arg Ala 
         435                440                445
Cys Trp Val Leu His Tyr Phe Cys Glu Val Lys Phe Lys Ser Asp Gln 
     450                455                460
Asn Leu Gln Thr Ala Leu Glu Leu Thr Arg Arg Cys Leu Ile Asp Asp 
 465                470                475                480
Arg Glu Met Pro Val Lys Val Glu Ala Ala Ile Ala Leu Gln Val Leu 
                 485                490                495
Ile Ser Asn Gln Glu Lys Ala Lys Glu Tyr Ile Thr Pro Phe Ile Arg 
             500                505                510
Pro Val Met Gln Ala Leu Leu His Ile Ile Arg Glu Thr Glu Asn Asp 
         515                520                525
Asp Leu Thr Asn Val Ile Gln Lys Met Ile Cys Glu Tyr Ser Glu Glu 
     530                535                540
Val Thr Pro Ile Ala Val Glu Met Thr Gln His Leu Ala Met Thr Phe 
 545                550                555                560
Asn Gln Val Ile Gln Thr Gly Pro Asp Glu Glu Gly Ser Asp Asp Lys 
                 565                570                575
Ala Val Thr Ala Met Gly Ile Leu Asn Thr Ile Asp Thr Leu Leu Ser 
             580                585                590
Val Val Glu Asp His Lys Glu Ile Thr Gln Gln Leu Glu Gly Ile Cys 
         595                600                605
Leu Gln Val Ile Gly Thr Val Leu Gln Gln His Val Leu Glu Phe Tyr 
     610                615                620
Glu Glu Ile Phe Ser Leu Ala His Ser Leu Thr Cys Gln Gln Val Ser 
 625                630                635                640
Pro Gln Met Trp Gln Leu Leu Pro Leu Val Phe Glu Val Phe Gln Gln 
                 645                650                655
Asp Gly Phe Asp Tyr Phe Thr Asp Met Met Pro Leu Leu His Asn Tyr 
             660                665                670
Val Thr Val Asp Thr Asp Thr Leu Leu Ser Asp Thr Lys Tyr Leu Glu 
         675                680                685
Met Ile Tyr Ser Met Cys Lys Lys Val Leu Thr Gly Val Ala Gly Glu 
     690                695                700
Asp Ala Glu Cys His Ala Ala Lys Leu Leu Glu Val Ile Ile Leu Gln 
 705                710                715                720
Cys Lys Gly Arg Gly Ile Asp Gln Cys Ile Pro Leu Phe Val Glu Ala 
                 725                730                735
Ala Leu Glu Arg Leu Thr Arg Glu Val Lys Thr Ser Glu Leu Arg Thr 
             740                745                750
Met Cys Leu Gln Val Ala Ile Ala Ala Leu Tyr Tyr Asn Pro His Leu 
         755                760                765
Leu Leu Asn Thr Leu Glu Asn Leu Arg Phe Pro Asn Asn Val Glu Pro 
     770                775                780
Val Thr Asn His Phe Ile Thr Gln Trp Leu Asn Asp Val Asp Cys Phe 
 785                790                795                800
Leu Gly Leu His Asp Arg Lys Met Cys Val Leu Gly Leu Cys Ala Leu 
                 805                810                815
Ile Asp Met Glu Gln Ile Pro Gln Val Leu Asn Gln Val Ser Gly Gln 
             820                825                830
Ile Leu Pro Ala Phe Ile Leu Leu Phe Asn Gly Leu Lys Arg Ala Tyr 
         835                840                845
Ala Cys His Ala Glu His Glu Asn Asp Ser Asp Asp Asp Asp Glu Ala 
     850                855                860
Glu Asp Asp Asp Glu Thr Glu Glu Leu Gly Ser Asp Glu Asp Asp Ile 
 865                870                875                880
Asp Glu Asp Gly Gln Glu Tyr Leu Glu Ile Leu Ala Lys Gln Ala Gly 
                 885                890                895
Glu Asp Gly Asp Asp Glu Asp Trp Glu Glu Asp Asp Ala Glu Glu Thr 
             900                905                910
Ala Leu Glu Gly Tyr Ser Thr Ile Ile Asp Asp Glu Asp Asn Pro Val 
         915                920                925
Asp Glu Tyr Gln Ile Phe Lys Ala Ile Phe Gln Thr Ile Gln Asn Arg 
     930                935                940
Asn Pro Val Trp Tyr Gln Ala Leu Thr His Gly Leu Asn Glu Glu Gln 
 945                950                955                960
Arg Lys Gln Leu Gln Asp Ile Ala Thr Leu Ala Asp Gln Arg Arg Ala 
                 965                970                975
Ala His Glu Ser Lys Met Ile Glu Lys His Gly Gly Tyr Lys Phe Ser 
             980                985                990
Ala Pro Val Val Pro Ser Ser Phe Asn Phe Gly Gly Pro Ala Pro Gly 
         995                1000                1005
Met Asn 
     1010



<210> 4725
<211> 475
<212> DNA
<213> Rattus norvegicus
<308> AA800753
<400> 4725

agacaacag  atgtagtag  tttgaatcc  ctgagatgt  gctttcaat  tgaaatatt  60
tgtatacat  tatataaaa  ataatccaa  gtatgactc  tctgacaga  gtttaagat  120
aataaagtt  ttgaacatg  atttaggaa  agaggggag  agcccaccc  gctaccctg  180
tgttgctgg  ttatttctg  agtggtctc  atagtggtt  ttagaggga  ccatgtgcc  240
tcagtcttc  gagttacga  aagatacca  aatcaagac  ggaggggaa  tggggaatg  300
gcaggtatt  atcttaaat  cattttgca  tctatctgg  acaagataa  aacaggtta  360
tggggatag  tattaatta  gaataaatt  cagtcagat  aagacataa  tgccgaatt  420
agtttttaa  agactgcat  tatagatgt  tagccatac  ctagatcaa  tcttt  475



<210> 4726
<211> 1039
<212> PRT
<213> Rattus norvegicus
<308> CAC17143
<400> 4726

Met Asp Pro Asn Thr Ile Ile Glu Ala Leu Arg Gly Thr Met Asp Pro 
  1               5                  10                  15
Ala Leu Arg Glu Ala Ala Glu Arg Gln Leu Asn Glu Ala His Lys Ser 
             20                  25                  30
Leu Asn Phe Val Ser Thr Leu Leu Gln Ile Thr Met Ser Glu Gln Leu 
         35                  40                  45
Asp Leu Pro Val Arg Gln Ala Gly Val Ile Tyr Leu Lys Asn Met Ile 
     50                  55                  60
Thr Gln Tyr Trp Pro Asp Arg Glu Ala Thr Pro Gly Asp Ile Ala Pro 
 65                  70                  75                  80
Tyr Thr Ile Pro Glu Glu Asp Arg His Cys Ile Arg Glu Asn Ile Val 
                 85                  90                  95
Glu Ala Ile Ile His Ser Pro Glu Leu Ile Arg Val Gln Leu Thr Thr 
             100                105                110
Cys Ile His His Ile Ile Lys His Asp Tyr Pro Ser Arg Trp Thr Ala 
         115                120                125
Ile Val Asp Lys Ile Gly Phe Tyr Leu Gln Ser Asp Asn Ser Ala Cys 
     130                135                140
Trp Leu Gly Ile Leu Leu Cys Leu Tyr Gln Leu Val Lys Asn Tyr Glu 
 145                150                155                160
Tyr Lys Lys Pro Glu Glu Arg Ser Pro Leu Val Ala Ala Met Gln His 
                 165                170                175
Phe Leu Pro Val Leu Lys Asp Arg Phe Ile Gln Leu Leu Ser Asp Gln 
             180                185                190
Ser Asp Gln Ser Val Leu Ile Gln Lys Gln Ile Phe Lys Ile Phe Tyr 
         195                200                205
Ala Leu Val Gln Tyr Thr Leu Pro Leu Glu Leu Ile Asn Gln Gln Asn 
     210                215                220
Leu Thr Glu Trp Val Glu Ile Leu Lys Thr Val Val Asn Arg Asp Val 
 225                230                235                240
Pro Asn Glu Thr Leu Gln Val Glu Glu Asp Asp Arg Pro Glu Leu Pro 
                 245                250                255
Trp Trp Lys Cys Lys Lys Trp Ala Leu His Ile Leu Ala Arg Leu Phe 
             260                265                270
Glu Arg Tyr Gly Ser Pro Gly Asn Val Ser Lys Glu Tyr Asn Glu Phe 
         275                280                285
Ala Glu Val Phe Leu Lys Ala Phe Ala Val Gly Val Gln Gln Val Leu 
     290                295                300
Leu Lys Val Leu Tyr Gln Tyr Lys Glu Lys Gln Tyr Met Ala Pro Arg 
 305                310                315                320
Val Leu Gln Gln Thr Leu Asn Tyr Ile Asn Gln Gly Val Ser His Ala 
                 325                330                335
Leu Thr Trp Lys Asn Leu Lys Pro His Ile Gln Gly Ile Ile Gln Asp 
             340                345                350
Val Ile Phe Pro Leu Met Cys Tyr Thr Asp Ala Asp Glu Glu Leu Trp 
         355                360                365
Gln Glu Asp Pro Tyr Glu Tyr Ile Arg Met Lys Phe Asp Val Phe Glu 
     370                375                380
Asp Phe Ile Ser Pro Thr Thr Ala Ala Gln Thr Leu Leu Phe Thr Ala 
 385                390                395                400
Cys Ser Lys Arg Lys Glu Val Val Leu Gln Lys Thr Met Gly Phe Cys 
                 405                410                415
Tyr Gln Ile Leu Thr Glu Pro Asn Ala Asp Pro Arg Lys Lys Asp Gly 
             420                425                430
Ala Leu His Met Ile Gly Ser Leu Ala Glu Ile Leu Leu Lys Lys Lys 
         435                440                445
Ile Tyr Lys Asp Gln Met Glu Tyr Met Leu Gln Asn His Val Phe Pro 
     450                455                460
Leu Phe Ser Ser Glu Leu Gly Tyr Met Arg Ala Arg Ala Cys Trp Val 
 465                470                475                480
Leu His Tyr Phe Cys Glu Val Lys Phe Lys Ser Asp Gln Asn Leu Gln 
                 485                490                495
Thr Ala Leu Glu Leu Thr Arg Arg Cys Leu Ile Asp Asp Arg Glu Met 
             500                505                510
Pro Val Lys Val Glu Ala Ala Ile Ala Leu Gln Val Leu Ile Ser Asn 
         515                520                525
Gln Glu Lys Ala Lys Glu Tyr Ile Thr Pro Phe Ile Arg Pro Val Met 
     530                535                540
Gln Ala Leu Leu His Ile Ile Arg Glu Thr Glu Asn Asp Asp Leu Thr 
 545                550                555                560
Asn Val Ile Gln Lys Met Ile Cys Glu Tyr Ser Glu Glu Val Thr Pro 
                 565                570                575
Ile Ala Val Glu Met Thr Gln His Leu Ala Met Thr Phe Asn Gln Val 
             580                585                590
Ile Gln Thr Gly Pro Asp Glu Glu Gly Ser Asp Asp Lys Ala Val Thr 
         595                600                605
Ala Met Gly Ile Leu Asn Thr Ile Asp Thr Leu Leu Ser Val Val Glu 
     610                615                620
Asp His Lys Glu Ile Thr Gln Gln Leu Glu Gly Ile Cys Leu Gln Val 
 625                630                635                640
Ile Gly Thr Val Leu Gln Gln His Val Leu Glu Phe Tyr Glu Glu Ile 
                 645                650                655
Phe Ser Leu Ala His Ser Leu Thr Cys Gln Gln Val Ser Pro Gln Met 
             660                665                670
Trp Gln Leu Leu Pro Leu Val Phe Glu Val Phe Gln Gln Asp Gly Phe 
         675                680                685
Asp Tyr Phe Thr Asp Met Met Pro Leu Leu His Asn Tyr Val Thr Val 
     690                695                700
Asp Thr Asp Thr Leu Leu Ser Asp Thr Lys Tyr Leu Glu Met Ile Tyr 
 705                710                715                720
Ser Met Cys Lys Lys Val Leu Thr Gly Val Ala Gly Glu Asp Ala Glu 
                 725                730                735
Cys His Ala Ala Lys Leu Leu Glu Val Ile Ile Leu Gln Cys Lys Gly 
             740                745                750
Arg Gly Ile Asp Gln Cys Ile Pro Leu Phe Val Glu Ala Ala Leu Glu 
         755                760                765
Arg Leu Thr Arg Glu Val Lys Thr Ser Glu Leu Arg Thr Met Cys Leu 
     770                775                780
Gln Val Ala Ile Ala Ala Leu Tyr Tyr Asn Pro His Leu Leu Leu Asn 
 785                790                795                800
Thr Leu Glu Asn Leu Arg Phe Pro Asn Asn Val Glu Pro Val Thr Asn 
                 805                810                815
His Phe Ile Thr Gln Trp Leu Asn Asp Val Asp Cys Phe Leu Gly Leu 
             820                825                830
His Asp Arg Lys Met Cys Val Leu Gly Leu Cys Ala Leu Ile Asp Met 
         835                840                845
Glu Gln Ile Pro Gln Val Leu Asn Gln Val Ser Gly Gln Ile Leu Pro 
     850                855                860
Ala Phe Ile Leu Leu Phe Asn Gly Leu Lys Arg Ala Tyr Ala Cys His 
 865                870                875                880
Ala Glu His Glu Asn Asp Ser Asp Asp Asp Glu Asp Ala Glu Asp Asp 
                 885                890                895
Asp Glu Thr Glu Glu Leu Gly Ser Asp Glu Asp Asp Ile Asp Glu Asp 
             900                905                910
Gly Gln Glu Tyr Leu Glu Ile Leu Ala Lys Gln Ala Gly Glu Asp Gly 
         915                920                925
Asp Asp Glu Asp Trp Glu Glu Asp Asp Ala Glu Glu Thr Ala Leu Glu 
     930                935                940
Gly Tyr Ser Thr Ile Ile Asp Asp Glu Asp Asn Pro Val Asp Glu Tyr 
 945                950                955                960
Gln Ile Phe Lys Ala Ile Phe Gln Thr Ile Gln Asn Arg Asn Pro Val 
                 965                970                975
Trp Tyr Gln Ala Leu Thr His Gly Leu Asn Glu Glu Gln Arg Lys Gln 
             980                985                990
Leu Gln Asp Ile Ala Thr Leu Ala Asp Gln Arg Arg Ala Ala His Glu 
         995                1000                1005
Ser Lys Met Ile Glu Lys His Gly Gly Tyr Lys Phe Ser Ala Pro Val 
     1010                1015                1020
Val Pro Ser Ser Phe Asn Phe Gly Gly Pro Ala Pro Gly Met Asn 
 1025                1030                1035



<210> 4727
<211> 2291
<212> DNA
<213> Homo sapiens
<308> AK027892
<400> 4727

ataatccac  cctactact  aatacctca  aaaatcttc  cttccctaa  aatgttgaa  60
cagttacaa  tcattttat  acacagtgg  ttaatgatg  tgactgttt  ttggggctt  120
atgacagaa  gatgtgtgt  ctcggactc  gtgctctta  tgatatgga  cagataccc  180
aagttttaa  tcaggtttc  ggacagatt  tgccggctt  tatcctttt  tttaacgga  240
tgaaaagag  atatgcctg  catgcagaa  atgagaatg  cagtgatga  gatgatgaa  300
ctgaagatg  tgatgaaac  gaggaactg  ggagtgatg  agatgatat  gatgaagat  360
ggcaagaat  tttggagat  ctggctaag  aggctggtg  agatggaga  gatgaagat  420
gggaagaag  tgatgctga  gagactgct  tggaaggct  ttccacaat  attgatgat  480
aagataacc  tgttgatga  tatcagata  ttaaagcta  ctttcaaac  attcaaaat  540
gtaatcctg  gtggtatca  gcgctgact  acggtctta  tgaagaaca  agaaaacag  600
tacaggaca  agcaactct  gctgatcaa  gaagagcag  ccatgaatc  aaaatgatt  660
agaagcatg  aggatacaa  ttcagtgct  cagttgtgc  aagttcttt  aattttgga  720
gcccagcac  agggatgaa  tgagttatc  ctttctttc  tgctgtgtg  ttgtagtga  780
gagcttgtg  tcctcctag  agtggttcc  gaactggtt  atgttatct  ttctaaact  840
ataatcaat  gatggacaa  agaaacaac  accccagga  atgggacct  atcatgcaa  900
ctggcactg  aaaagaaat  agcgggatt  tgggggtgg  ggggatggg  ggtacctta  960
agggagtat  ttctttatt  tttgaagaa  gtaagatcc  gactctgaa  cttcaaagt  1020
acactgtgg  aatctgaaa  gaggggatg  catgaaggc  gcttttctt  ttctgagga  1080
aaaataggc  tgggctaca  gactattta  aatgtctca  ttacagtat  aaactcaaa  1140
gtagatgta  tttttacac  tatgagtat  tgtccaatt  ctgtctctt  ctcaccatt  1200
ggtatctat  ctttatatg  aaataagat  aggtcatct  atagcctta  tcagtcttc  1260
tcattttca  cattgttcc  atgtagatt  ttggacatt  attgtagca  tacataact  1320
attataaaa  tctgtaaat  aattagcac  ttcatattg  aacaagcct  ctagcctat  1380
tataaaata  caaaatgtt  gctgtttat  aaaagatgt  atggggtgg  gggcagggg  1440
aatttcaag  tattaattt  aaaatgaac  agcaatttt  tacctggtg  ctttgtggt  1500
cactcacct  tgatagtga  ttgaattcg  tatgtaaaa  ggggttagt  gtatttcat  1560
gctgctaaa  atgacaact  cctctgtgt  ctgtttttc  taaagctgt  agtgtacaa  1620
tgggtattt  aataccaga  cttactgta  aaaataaaa  aggtggtat  tagagcatg  1680
aaattggat  taaagttct  ctcttaaag  gttgatcta  gagtatggc  aaacatcta  1740
atatgcaat  tattaaaag  acttaattc  gctattatg  cttgatttg  ttgcagttt  1800
ttcctaatt  taacaaatt  ttcctcatt  gcctgtttt  aatcctgtg  ctagaagga  1860
tacaaaatg  acactttac  aaattgata  ttaacactt  cccactccc  tttccccat  1920
tcttctacc  ctcttgttg  tcgtggtat  tgatcttga  tagataggc  gaaggcaca  1980
ggttccctc  aaaaaccac  attgatacc  ctacaaaaa  aagccagca  aaagatact  2040
tagagaggt  ggcttgctt  cctctcttc  taactgcat  ttgaaaaat  agccgttat  2100
gatcttaaa  atcggtcag  tgagtcata  attgggtta  tttttatat  catgtatac  2160
caaaatatt  caaattgaa  gcaacatct  aatggattc  aaactatta  aagctgttg  2220
ctaaaacag  tgagaaaaa  atttataac  gtaaaaaca  atgcacata  tgatattta  2280
aatgcgtaa  t  2291



<210> 4728
<211> 1010
<212> PRT
<213> Homo sapiens
<308> CAC17609
<400> 4728

Ala His Lys Ser Leu Asn Phe Val Ser Thr Leu Leu Gln Ile Thr Met 
  1               5                  10                  15
Ser Glu Gln Leu Asp Leu Pro Val Arg Gln Ala Gly Val Ile Tyr Leu 
             20                  25                  30
Lys Asn Met Ile Thr Gln Tyr Trp Pro Asp Arg Glu Thr Ala Pro Gly 
         35                  40                  45
Asp Ile Ser Pro Tyr Thr Ile Pro Glu Glu Asp Arg His Cys Ile Arg 
     50                  55                  60
Glu Asn Ile Val Glu Ala Ile Ile His Ser Pro Glu Leu Ile Arg Val 
 65                  70                  75                  80
Gln Leu Thr Thr Cys Ile His His Ile Ile Lys His Asp Tyr Pro Ser 
                 85                  90                  95
Arg Trp Thr Ala Ile Val Asp Lys Ile Gly Phe Tyr Leu Gln Ser Asp 
             100                105                110
Asn Ser Ala Cys Trp Leu Gly Ile Leu Leu Cys Leu Tyr Gln Leu Val 
         115                120                125
Lys Asn Tyr Glu Tyr Lys Lys Pro Glu Glu Arg Ser Pro Leu Val Ala 
     130                135                140
Ala Met Gln His Phe Leu Pro Val Leu Lys Asp Arg Phe Ile Gln Leu 
 145                150                155                160
Leu Ser Asp Gln Ser Asp Gln Ser Val Leu Ile Gln Lys Gln Ile Phe 
                 165                170                175
Lys Ile Phe Tyr Ala Leu Val Gln Tyr Thr Leu Pro Leu Glu Leu Ile 
             180                185                190
Asn Gln Gln Asn Leu Thr Glu Trp Ile Glu Ile Leu Lys Thr Val Val 
         195                200                205
Asn Arg Asp Val Pro Asn Glu Thr Leu Gln Val Glu Glu Asp Asp Arg 
     210                215                220
Pro Glu Leu Pro Trp Trp Lys Cys Lys Lys Trp Ala Leu His Ile Leu 
 225                230                235                240
Ala Arg Leu Phe Glu Arg Tyr Gly Ser Pro Gly Asn Val Ser Lys Glu 
                 245                250                255
Tyr Asn Glu Phe Ala Glu Val Phe Leu Lys Ala Phe Ala Val Gly Val 
             260                265                270
Gln Gln Val Leu Leu Lys Val Leu Tyr Gln Tyr Lys Glu Lys Gln Tyr 
         275                280                285
Met Ala Pro Arg Val Leu Gln Gln Thr Leu Asn Tyr Ile Asn Gln Gly 
     290                295                300
Val Ser His Ala Leu Thr Trp Lys Asn Leu Lys Pro His Ile Gln Gly 
 305                310                315                320
Ile Ile Gln Asp Val Ile Phe Pro Leu Met Cys Tyr Thr Asp Ala Asp 
                 325                330                335
Glu Glu Leu Trp Gln Glu Asp Pro Tyr Glu Tyr Ile Arg Met Lys Phe 
             340                345                350
Asp Val Phe Glu Asp Phe Ile Ser Pro Thr Thr Ala Ala Gln Thr Leu 
         355                360                365
Leu Phe Thr Ala Cys Ser Lys Arg Lys Glu Val Leu Gln Lys Thr Met 
     370                375                380
Gly Phe Cys Tyr Gln Ile Leu Thr Glu Pro Asn Ala Asp Pro Arg Lys 
 385                390                395                400
Lys Asp Gly Ala Leu His Met Ile Gly Ser Leu Ala Glu Ile Leu Leu 
                 405                410                415
Lys Lys Lys Ile Tyr Lys Asp Gln Met Glu Tyr Met Leu Gln Asn His 
             420                425                430
Val Phe Pro Leu Phe Ser Ser Glu Leu Gly Tyr Met Arg Ala Arg Ala 
         435                440                445
Cys Trp Val Leu His Tyr Phe Cys Glu Val Lys Phe Lys Ser Asp Gln 
     450                455                460
Asn Leu Gln Thr Ala Leu Glu Leu Thr Arg Arg Cys Leu Ile Asp Asp 
 465                470                475                480
Arg Glu Met Pro Val Lys Val Glu Ala Ala Ile Ala Leu Gln Val Leu 
                 485                490                495
Ile Ser Asn Gln Glu Lys Ala Lys Glu Tyr Ile Thr Pro Phe Ile Arg 
             500                505                510
Pro Val Met Gln Ala Leu Leu His Ile Ile Arg Glu Thr Glu Asn Asp 
         515                520                525
Asp Leu Thr Asn Val Ile Gln Lys Met Ile Cys Glu Tyr Ser Glu Glu 
     530                535                540
Val Thr Pro Ile Ala Val Glu Met Thr Gln His Leu Ala Met Thr Phe 
 545                550                555                560
Asn Gln Val Ile Gln Thr Gly Pro Asp Glu Glu Gly Ser Asp Asp Lys 
                 565                570                575
Ala Val Thr Ala Met Gly Ile Leu Asn Thr Ile Asp Thr Leu Leu Ser 
             580                585                590
Val Val Glu Asp His Lys Glu Ile Thr Gln Gln Leu Glu Gly Ile Cys 
         595                600                605
Leu Gln Val Ile Gly Thr Val Leu Gln Gln His Val Leu Glu Phe Tyr 
     610                615                620
Glu Glu Ile Phe Ser Leu Ala His Ser Leu Thr Cys Gln Gln Val Ser 
 625                630                635                640
Pro Gln Met Trp Gln Leu Leu Pro Leu Val Phe Glu Val Phe Gln Gln 
                 645                650                655
Asp Gly Phe Asp Tyr Phe Thr Asp Met Met Pro Leu Leu His Asn Tyr 
             660                665                670
Val Thr Val Asp Thr Asp Thr Leu Leu Ser Asp Thr Lys Tyr Leu Glu 
         675                680                685
Met Ile Tyr Ser Met Cys Lys Lys Val Leu Thr Gly Val Ala Gly Glu 
     690                695                700
Asp Ala Glu Cys His Ala Ala Lys Leu Leu Glu Val Ile Ile Leu Gln 
 705                710                715                720
Cys Lys Gly Arg Gly Ile Asp Gln Cys Ile Pro Leu Phe Val Glu Ala 
                 725                730                735
Ala Leu Glu Arg Leu Thr Arg Glu Val Lys Thr Ser Glu Leu Arg Thr 
             740                745                750
Met Cys Leu Gln Val Ala Ile Ala Ala Leu Tyr Tyr Asn Pro His Leu 
         755                760                765
Leu Leu Asn Thr Leu Glu Asn Leu Arg Phe Pro Asn Asn Val Glu Pro 
     770                775                780
Val Thr Asn His Phe Ile Thr Gln Trp Leu Asn Asp Val Asp Cys Phe 
 785                790                795                800
Leu Gly Leu His Asp Arg Lys Met Cys Val Leu Gly Leu Cys Ala Leu 
                 805                810                815
Ile Asp Met Glu Gln Ile Pro Gln Val Leu Asn Gln Val Ser Gly Gln 
             820                825                830
Ile Leu Pro Ala Phe Ile Leu Leu Phe Asn Gly Leu Lys Arg Ala Tyr 
         835                840                845
Ala Cys His Ala Glu His Glu Asn Asp Ser Asp Asp Asp Asp Glu Ala 
     850                855                860
Glu Asp Asp Asp Glu Thr Glu Glu Leu Gly Ser Asp Glu Asp Asp Ile 
 865                870                875                880
Asp Glu Asp Gly Gln Glu Tyr Leu Glu Ile Leu Ala Lys Gln Ala Gly 
                 885                890                895
Glu Asp Gly Asp Asp Glu Asp Trp Glu Glu Asp Asp Ala Glu Glu Thr 
             900                905                910
Ala Leu Glu Gly Tyr Ser Thr Ile Ile Asp Asp Glu Asp Asn Pro Val 
         915                920                925
Asp Glu Tyr Gln Ile Phe Lys Ala Ile Phe Gln Thr Ile Gln Asn Arg 
     930                935                940
Asn Pro Val Trp Tyr Gln Ala Leu Thr His Gly Leu Asn Glu Glu Gln 
 945                950                955                960
Arg Lys Gln Leu Gln Asp Ile Ala Thr Leu Ala Asp Gln Arg Arg Ala 
                 965                970                975
Ala His Glu Ser Lys Met Ile Glu Lys His Gly Gly Tyr Lys Phe Ser 
             980                985                990
Ala Pro Val Val Pro Ser Ser Phe Asn Phe Gly Gly Pro Ala Pro Gly 
         995                1000                1005
Met Asn 
     1010



<210> 4729
<211> 727
<212> DNA
<213> Rattus norvegicus
<308> AA800768
<400> 4729

aggaatgag  tattttaat  aagcaaaac  aatttatat  cattatttc  aaaaataaa  60
ttagacctt  ccaaccctt  acatctgca  ttaatcata  ttcctaacc  aaatacaga  120
gctaaaaac  gcaagttac  atatatctt  acagcatac  gtatgttca  tgtttacac  180
ttaattcta  ttggtcatt  tgtacttga  gcatactta  acaccactc  taacattta  240
acaatcaac  aaaaaatgt  accagttgt  ttaaaatgg  tctgctata  attgtatag  300
atatacaga  ttacaaagt  aagtatttt  tcaaaatat  caccccctc  ctgaaacta  360
cacaagcta  caacatttt  aatgaataa  acaattata  aaaatattt  caaaattat  420
tgtatgtat  aatattctg  catatttac  ttggtctag  attatcagc  tacaagtcc  480
cttaaaaaa  atccacata  tgatgggag  catcaatac  tataacttt  tttgtagtt  540
aatcaaaac  acttaaatc  ataattgtt  tataatcat  actgagata  aacaaatta  600
tggatcaca  gattgcttg  catctggtt  ttaattcaa  agtgatttt  ataagccct  660
tgtgaccac  tcaataaaa  tcaaatggt  tgggtgcac  tatatacaa  ggacaaaac  720
aagttca  727



<210> 4730
<211> 474
<212> DNA
<213> Homo sapiens
<308> AW573102
<400> 4730

tatcaaaat  tacacccct  cctgaaact  acacaagct  tcaacattt  aaatgaata  60
aattataga  aatatttgc  aaattattt  ttcatgtat  aatattctg  catatttac  120
ttggtctag  attatcagc  tacaagtcc  cttaaaaaa  atccacata  aagggctgg  180
agagagaca  cactacagg  aattttata  ttggggtta  ctcaaatca  aatgactag  240
atatacagt  aatgtcttt  attaatatt  ttaactgat  aaacaaatt  gtggatcat  300
ggattgctt  ttcaatatt  taattatca  ttcaaaaat  attttcgta  gccctttgt  360
actatctct  taataaaac  caaatgaat  gtgtagggt  tacatatat  caatgtata  420
aataaagtt  aatttgctt  cattttccc  tttttctct  cttatataa  actg  474



<210> 4732
<211> 577
<212> DNA
<213> Rattus norvegicus
<308> AA800782
<400> 4732

cgttttacg  ccttatttt  aattaaaga  gattgttac  acatatttt  aaaaaccac  60
ttttaaatt  aattacaaa  gagatgaag  cccaagtac  gagagacat  tttgcattt  120
agctgattt  ttaaaaaga  tgatcacaa  ttacaggcc  ggagttttt  tttgtactt  180
aagatctgg  gggcactac  cttctaaaa  tcacttctg  ttttacgta  ttaaacttt  240
aggacagta  gctcaaaat  cacctcaaa  ttagtagta  agggactga  aaacaattg  300
cctgataat  cagtcttag  tttatttat  tatttaacc  acaaggctt  aatctacat  360
gaaggtgtg  tgccaagtc  cactcagag  tcattacaa  ccagaaagg  gggaggatg  420
gtattcatt  tctcaagct  aaaacccga  atttcgaac  attcaacat  actcaggtt  480
ttacgcaca  ttcatttaa  aatgtggtg  tatacattg  atcccactt  ctaggagaa  540
ttcgcacct  tttagtctt  tcattcccg  tattcag  577



<210> 4733
<211> 520
<212> DNA
<213> Rattus norvegicus
<308> AA800787
<400> 4733

ttagaagca  tgttgggca  acagacagg  aaatatctg  gaagagata  cgtacatca  60
ctagcactt  aaacagttg  agagaaaac  tggaaagta  ttacatgga  cagtttctt  120
tacaaatac  aaagtgtgg  aaacatccc  aaccaaata  agtattacc  tcgagaagc  180
aaaccagta  aacaaaaca  aaatacaaa  aaaaaaaat  caaagatag  gtgtattgt  240
tataggaaa  aatagtgta  atagcagac  taaactggc  catgtaaaa  acaaaaata  300
ttattgaaa  cagatcttt  tataaaaca  tgctttgga  gtatcttaa  atgaatcca  360
tatatgatc  aaatgtaaa  tcgtttaga  acattaaca  cattaagcc  gtgccaccc  420
cttgttcca  ttagtcctt  tttaaaagc  gttttgttg  ttcatgaca  atacataag  480
cctatgttc  taaaagcac  atccattct  ttagaattaa  520



<210> 4734
<211> 4006
<212> DNA
<213> Homo sapiens
<308> NM_013995
<400> 4734

ccgattcct  gcttttgca  ggctgtggt  ggtggtcat  agtgctctt  acccaggtc  60
agcgagcct  ttccctggt  ttgcagctg  tgttgtacc  ccgccgtcg  cgccgtcgc  120
gcctgctct  cggggtcat  gtgtgcttc  gcctcttcc  ggttccggg  tcagggctc  180
ttctggtct  cctagtcct  ggagctgtg  ggtcttatg  attggaact  aatttgaca  240
attcagaaa  tgccacttg  ctttatgca  aatggcaga  gaatttcac  gtacgctat  300
aaactacaa  taaaactta  aaaactgta  ccatttcag  ccatggcac  gtgacatat  360
atggaagca  ttgtgggga  gatcagaat  gtcccaaaa  agcagtgca  ttcggacct  420
gcttttcct  gattgcgaa  tttaccaag  cagcatcta  ttattcaat  gacagcgtc  480
cattttcct  caacactgg  gataacaca  catttcctg  tgctgaaga  aaaggaatt  540
ttactgttg  tgaactttt  gccatcaga  ttccattga  tgacctttt  agatgcaat  600
gtttatcaa  tttggaaaa  aatgatgtt  tccaacact  ctgggatgt  cttgtacaa  660
cttttgtcc  aaatggcac  gtgagcaca  atgagttcc  gtgtgataa  gacaaaact  720
caacagtgg  acccaccat  cacaccact  tgccatctc  tactacaac  cctactcca  780
aggaaaaac  agaagctgg  acctattca  ttaataatg  caatgatac  tgtctgctg  840
ctaccatgg  gctgcagct  aacatcact  aggataagg  tgcttcagt  attaacatc  900
accccaata  aactcactc  acaggcagc  gccgttctc  cactgctct  cttagactc  960
atagcagca  cattaagta  ctagacttt  tctttgctg  gaaaaatga  aaccgattt  1020
atctgaagg  agtgaacat  agcatgtat  tggttaatg  ctccgtttt  agcattgca  1080
ataacaatc  cagctactg  gatgccccc  tgggaagtt  ttatatgtg  aacaaagag  1140
agactgttt  agtgtctgg  gcatttcag  taaatacct  tgatctaag  gttcagcct  1200
tcaatgtga  acaaggaaa  tattctaca  cccaagagt  ttcgctgga  gatgacacc  1260
ttctaatcc  aattatagt  ggtgctggt  tttcaggct  gattatcgt  atagtgatt  1320
cttacgtaa  tggcagaag  aaaagttat  ctggatatc  gactctgta  cactaatca  1380
tacgtgatc  ctgttacaa  agaaaaaag  aagtacaag  tccaacatg  aatactggt  1440
aacttaagg  atatttagt  gcagtccag  tctttagaa  gggtggtat  ggggatttc  1500
aacttaaac  aaaaactat  aactacaaa  tagttgcct  actttggtt  ttccaacca  1560
ggaatttaa  actgttatt  ttacagcaa  agatgtgca  aatcactgg  ttataagtt  1620
tattttact  tcttgaatt  gtatttcag  gttttcatt  tagacattc  gactaaaaa  1680
acaccgttt  gaaaaaaca  tttttgaaa  agagatttt  tttccctgc  ggtagttga  1740
ttgaacaac  tgttctacc  tggatttgt  cttgctcct  ttgctcttt  tgtgtgtgt  1800
tgtgtgtgt  tgtgtgtgt  tgtgatttt  gtttgcagg  taacttagc  actttggca  1860
tgctgcata  ttgaccttt  agagatata  tagtagatt  gaacagggg  tggtattat  1920
atgttctta  caataaatg  ttttctaat  ccttttgaa  acatttgta  ttatgtggc  1980
gtaatgaca  aagatacaa  agcttttta  aatttagag  aggtattaa  cttattgtt  2040
aatcttttt  ttaaaaaaa  tggatattt  aatctttta  attgcaata  ataagacta  2100
tccaactgg  catttcaat  catttttta  gtgctttag  gataattgc  tgccagtgc  2160
aattgaggg  attagtact  tgtgctcat  aattggcct  tgtatgcag  actaaaatt  2220
atgcagatt  ctctttagc  ttccaacat  tcttgttga  agtgatgta  tttattatt  2280
tctttttct  aagaaatgc  agtgtgtcc  agaacctag  taacgaagt  cacttacac  2340
tataaaata  cttgcatct  ggctgggcg  ggcggctca  gcctgtaat  ccagcactt  2400
gggaggccg  agtgggtgg  tcacttgag  ccaggagtt  gagaccagc  tggccaaca  2460
ggtgaaacc  catctctat  agaaataca  aaaattagc  gggcatggt  gtgggcgcc  2520
gtaatccca  ttactcggg  ggctgaggc  ggagaatca  ttgaacccg  gaggcagag  2580
ttgcggtga  ccaagagcg  accattgca  tccagcctt  ggcgacaaa  acgaaactc  2640
atcttcaaa  caaaacaaa  caaaacaaa  aaacaaaca  aacttgcat  ttaaccaaa  2700
gtcttggtt  tatcttaat  cattaaaag  tggtcttgt  tccagcttg  attgattgc  2760
acaacatca  taatttggc  ttcacattt  aatggttct  tgctaatca  aactttcgt  2820
gttattatt  gttatggta  aatcatttt  aattcacgt  ctttgtgtt  agttttgtg  2880
tctgagaga  gtaccaatt  tcaaattac  gtgtaccac  taatgttta  aggagaaag  2940
aaaatacat  agcttggta  ttaacacat  aaatatttc  tgctgcttc  aggagaact  3000
ttttggtgt  tgttggaat  gctgagcaa  tattaaaat  gttaatatg  agccatata  3060
ggaaggttc  tgtggggtt  ttttttcgt  ttttttttt  ttgtggtgg  attatgtgc  3120
tcccattca  tagaaaatg  gaaaattgt  tgggttcca  aatattgac  ttgaatgga  3180
caatacaca  acacagaca  atatatata  atatgcaca  atatatagg  agttgcatg  3240
ctagcatgg  tattttata  ccatataac  gagttatat  ggaattata  atattttcc  3300
tcacttaaa  ttgttcttt  tttagcctg  aaaccttta  ggctcaaga  cagattcct  3360
actaacccc  ctcttagag  tacagcgag  tgcattacc  gcttaaaac  cttcttagg  3420
attaaatat  gatgtaatt  ttcaaaatc  tttttaatt  aaactgtgt  ttagtgtaa  3480
attgttaac  ttgtaagat  gataatgtg  ataagaatg  aggccttaa  tatttcaca  3540
gagtcaaaa  aaagcagct  taaaaaaat  attggaagc  caatgcatg  cactgactg  3600
atgctgtta  tatttctaa  agtttctac  ttcagatta  atgcctgat  catagtaaa  3660
tacctctaa  aaacactgt  ttatagaaa  cctgacttc  gtgaatatt  ttgtatttt  3720
catgggcca  tttatatac  gctatttac  ctattattt  ctatagcta  atgttcttt  3780
taccttttg  agttttatt  gtattacta  attcatacc  tgatggtaa  gctctatct  3840
gttttgggt  tttttcatg  tttagcatt  gtataaaga  actggtcca  gtaaatact  3900
tccatgttt  ttcttcaaa  gtttaaacc  ctagttgat  tatggtatc  ttagatatt  3960
gcctgtctg  ttgctcaaa  ttgcttcta  aacaataaa  attctt  4006



<210> 4735
<211> 410
<212> PRT
<213> Homo sapiens
<308> P13473
<400> 4735

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
  1               5                  10                  15
Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
             20                  25                  30
Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
         35                  40                  45
Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
     50                  55                  60
Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
 65                  70                  75                  80
Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                 85                  90                  95
Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
             100                105                110
Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
         115                120                125
Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
     130                135                140
Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
 145                150                155                160
Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                 165                170                175
Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
             180                185                190
Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
         195                200                205
Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
     210                215                220
Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
 225                230                235                240
Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                 245                250                255
Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
             260                265                270
Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
         275                280                285
Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
     290                295                300
Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
 305                310                315                320
Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                 325                330                335
Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
             340                345                350
Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Asp Cys 
         355                360                365
Ser Ala Asp Asp Asp Asn Phe Leu Val Pro Ile Ala Val Gly Ala Ala 
     370                375                380
Leu Ala Gly Val Leu Ile Leu Val Leu Leu Ala Tyr Phe Ile Gly Leu 
 385                390                395                400
Lys His His His Ala Gly Tyr Glu Gln Phe 
                 405                410



<210> 4736
<211> 644
<212> DNA
<213> Rattus norvegicus
<308> AA800794
<400> 4736

gaagaaagt  actagtttt  ttagtttaa  gcttcatag  acagaaaga  atctcaaag  60
caaacaata  gcactcact  gaagaaaat  cagagttag  tacctaatg  tttgttctt  120
cgtaatgaa  atggatacg  cgaccttcc  ccgcattgt  ggtcgaagc  cacataatc  180
aattcttcc  aaaactctt  gcataggtc  atggaagga  tatgaaaca  tctgagccc  240
aaaaaatat  caggtttgc  ggatatgtt  gcaaggctt  cctgttcct  tctgccttg  300
ctatggcat  attctaacc  agaaactcc  ttaaaaggc  agtgatttc  agactcaag  360
gttcaacac  atccaacta  ggtcagtca  accatcctc  cgcacatct  caagagaag  420
caatctatg  tggcagaaa  tcccagtca  gaggtcctg  ttcccaaag  gactttgtg  480
caccttagt  acacttaat  atacagtct  acactggta  aggtgatca  aggagacac  540
atgctacag  gatataata  cactgacgg  ttgagcaga  cccactgga  catgcacac  600
gaatgcagc  agagttaaa  ccacagatg  agcacactg  aaca  644



<210> 4737
<211> 2424
<212> DNA
<213> Homo sapiens
<308> U18543
<400> 4737

gtgggctcg  cggagccgc  ggcggtcag  aggaatttg  ccctctagg  catgaatac  60
gtgctgttc  gttctgagc  gtgctagca  tacccttca  aggaagagc  atggctgca  120
cagcagctt  tcacctgaa  ctggatgcc  tccgggaag  gctagaatg  cccatctgc  180
tggagtcca  cacagaaga  cagctgcgt  ccaagcttc  gcactgtgg  cataccatc  240
gccgccagt  cctggagaa  ctattggcc  gtagcatca  tggtgtccg  tgtcccttt  300
gcagcaaga  tacccgcat  accagcttg  cccagctga  agacaatct  acagtgcta  360
agatcattg  tacagctgg  ctcagcgag  ctgtggggc  gctcatgtg  cggtcctgt  420
ggcggcgtc  gccccggca  ttctgccgg  gctgtggtt  ggtgttatg  gagccctgc  480
gggaggcag  ccatcagcc  cctggccac  gtacactcc  tgtcaaaga  gcagctgag  540
agcggcgtc  ggactttgg  gagaagtta  ctcgtctgc  ggaacttat  ggggagctg  600
agcggcgga  ggcagcctt  gaaggtgtc  ccaaggacc  tcaggcaag  tataaagca  660
ttctccagg  gtatgggca  gaggagcgc  gggtccagg  tgagctggc  cgctctcgg  720
agttcttca  aggctcttt  gctgaagtt  agaagtcca  tagtcaagt  gtagaggag  780
agagttacc  gcttaacat  gcagaggtg  aggctgtgt  tcgctgtga  tacttcctg  840
ccaagatca  gcaggcaga  gtagcacta  tggaggaga  agctgatga  gaggagcca  900
agctcactg  cagcttgcc  cgggagctc  ccctgcaag  tgtggagct  cttaaggta  960
gtcatgttg  ccccctcca  attggacaa  ctgttaaga  gccccggac  gttaacgtg  1020
aagattcct  ggccatgga  gccacagcg  ctgctgcct  tacctctgt  acttttaga  1080
agatggaca  gagcccgga  gaagtggtt  ccagcccta  ggcctcacc  gctaaacag  1140
ggggtcctg  ggcagcctc  aatatccag  agtgcctct  tctcaagaa  atgggggcc  1200
aaggcagca  tccaggaat  ttcaatctt  cagtcagtc  ctacgtgac  agtcaaggt  1260
aagtactag  cgctgaccg  ggtaactat  gtatacaag  ctttacccg  aaaggcttt  1320
tgaaggaaa  ccgccgcag  cccagtggc  ttgatagct  tgtgctaag  ttccttggg  1380
cagatctac  caacctcac  cctctctca  tggcaatga  ctgccaggg  ctgattggt  1440
tgactgaca  ctatgataa  tccctcaag  tatatacct  ggatggcca  tgcgtggcc  1500
gtcacagga  ccagctgag  aaaccatgg  gtatcacag  cttgccatc  ggccagttt  1560
tagtaaccg  tgtggaagg  ggaaagctt  ggtgtttca  agttgatcg  ggatcaggg  1620
tggtcaaat  cagctgcct  tgtagtgct  tgcggccca  atttgtcac  tgtgatgct  1680
agggcaccg  ctacttcac  cagggctta  gcctcaatc  ggagaatcg  cagaatgag  1740
accacctgg  gggtggctt  tccattggc  ctgtaggcc  tgatgggca  ctgggtcgc  1800
agattagcc  cttcttctc  gagaatgag  atttccgct  cattgctgg  atgtgtgtg  1860
atgctcgtg  tgatctcat  gtggctgac  gtagtcgca  ggaaattct  cattttcct  1920
agggcgggg  ctatagtgt  cttattcga  agggactta  ctgtccggt  ggcatagcc  1980
taactccta  ggggcagct  ctggtcttg  actgttggg  tcattgcat  aagatctac  2040
gctaccatc  gagaagata  tccacccca  aggggatga  aaattatca  tttcttctg  2100
tcccaagcc  acttccctt  ccttagttc  tggttgtta  tggcacatg  agaatagac  2160
cagcctatg  cctgattcc  gctgggtag  tctagaact  tagaagctc  atcttttaa  2220
gtttttatt  gttatgtcc  cctcccggc  tcccaccta  atttagagc  ttaaaagat  2280
cactgccca  ataggacac  cgatggtgt  agctgaagt  tgattagca  ttaggcact  2340
ccaaggctt  agtagagag  gccacttta  ccctttgtg  catgtttga  atttgccct  2400
gtattaaat  cttgatttt  tccc  2424



<210> 4738
<211> 653
<212> PRT
<213> Homo sapiens
<308> Q13049
<400> 4738

Met Ala Ala Ala Ala Ala Ser His Leu Asn Leu Asp Ala Leu Arg Glu 
  1               5                  10                  15
Val Leu Glu Cys Pro Ile Cys Met Glu Ser Phe Thr Glu Glu Gln Leu 
             20                  25                  30
Arg Pro Lys Leu Leu His Cys Gly His Thr Ile Cys Arg Gln Cys Leu 
         35                  40                  45
Glu Lys Leu Leu Ala Ser Ser Ile Asn Gly Val Arg Cys Pro Phe Cys 
     50                  55                  60
Ser Lys Ile Thr Arg Ile Thr Ser Leu Thr Gln Leu Thr Asp Asn Leu 
 65                  70                  75                  80
Thr Val Leu Lys Ile Ile Asp Thr Ala Gly Leu Ser Glu Ala Val Gly 
                 85                  90                  95
Leu Leu Met Cys Arg Ser Cys Gly Arg Arg Leu Pro Arg Gln Phe Cys 
             100                105                110
Arg Ser Cys Gly Leu Val Leu Cys Glu Pro Cys Arg Glu Ala Asp His 
         115                120                125
Gln Pro Pro Gly His Cys Thr Leu Pro Val Lys Glu Ala Ala Glu Glu 
     130                135                140
Arg Arg Arg Asp Phe Gly Glu Lys Leu Thr Arg Leu Arg Glu Leu Met 
 145                150                155                160
Gly Glu Leu Gln Arg Arg Lys Ala Ala Leu Glu Gly Val Ser Lys Asp 
                 165                170                175
Leu Gln Ala Arg Tyr Lys Ala Val Leu Gln Glu Tyr Gly His Glu Glu 
             180                185                190
Arg Arg Val Gln Asp Glu Leu Ala Arg Ser Arg Lys Phe Phe Thr Gly 
         195                200                205
Ser Leu Ala Glu Val Glu Lys Ser Asn Ser Gln Val Val Glu Glu Gln 
     210                215                220
Ser Tyr Leu Leu Asn Ile Ala Glu Val Gln Ala Val Ser Arg Cys Asp 
 225                230                235                240
Tyr Phe Leu Ala Lys Ile Lys Gln Ala Asp Val Ala Leu Leu Glu Glu 
                 245                250                255
Thr Ala Asp Glu Glu Glu Pro Glu Leu Thr Ala Ser Leu Pro Arg Glu 
             260                265                270
Leu Thr Leu Gln Asp Val Glu Leu Leu Lys Val Gly His Val Gly Pro 
         275                280                285
Leu Gln Ile Gly Gln Ala Val Lys Lys Pro Arg Thr Val Asn Val Glu 
     290                295                300
Asp Ser Trp Ala Met Glu Ala Thr Ala Ser Ala Ala Ser Thr Ser Val 
 305                310                315                320
Thr Phe Arg Glu Met Asp Met Ser Pro Glu Glu Val Val Ala Ser Pro 
                 325                330                335
Arg Ala Ser Pro Ala Lys Gln Arg Gly Pro Glu Ala Ala Ser Asn Ile 
             340                345                350
Gln Gln Cys Leu Phe Leu Lys Lys Met Gly Ala Lys Gly Ser Thr Pro 
         355                360                365
Gly Met Phe Asn Leu Pro Val Ser Leu Tyr Val Thr Ser Gln Gly Glu 
     370                375                380
Val Leu Val Ala Asp Arg Gly Asn Tyr Arg Ile Gln Val Phe Thr Arg 
 385                390                395                400
Lys Gly Phe Leu Lys Glu Ile Arg Arg Ser Pro Ser Gly Ile Asp Ser 
                 405                410                415
Phe Val Leu Ser Phe Leu Gly Ala Asp Leu Pro Asn Leu Thr Pro Leu 
             420                425                430
Ser Val Ala Met Asn Cys Gln Gly Leu Ile Gly Val Thr Asp Ser Tyr 
         435                440                445
Asp Asn Ser Leu Lys Val Tyr Thr Leu Asp Gly His Cys Val Ala Cys 
     450                455                460
His Arg Ser Gln Leu Ser Lys Pro Trp Gly Ile Thr Ala Leu Pro Ser 
 465                470                475                480
Gly Gln Phe Val Val Thr Asp Val Glu Gly Gly Lys Leu Trp Cys Phe 
                 485                490                495
Thr Val Asp Arg Gly Ser Gly Val Val Lys Tyr Ser Cys Leu Cys Ser 
             500                505                510
Ala Val Arg Pro Lys Phe Val Thr Cys Asp Ala Glu Gly Thr Val Tyr 
         515                520                525
Phe Thr Gln Gly Leu Gly Leu Asn Leu Glu Asn Arg Gln Asn Glu His 
     530                535                540
His Leu Glu Gly Gly Phe Ser Ile Gly Ser Val Gly Pro Asp Gly Gln 
 545                550                555                560
Leu Gly Arg Gln Ile Ser His Phe Phe Ser Glu Asn Glu Asp Phe Arg 
                 565                570                575
Cys Ile Ala Gly Met Cys Val Asp Ala Arg Gly Asp Leu Ile Val Ala 
             580                585                590
Asp Ser Ser Arg Lys Glu Ile Leu His Phe Pro Lys Gly Gly Gly Tyr 
         595                600                605
Ser Val Leu Ile Arg Glu Gly Leu Thr Cys Pro Val Gly Ile Ala Leu 
     610                615                620
Thr Pro Lys Gly Gln Leu Leu Val Leu Asp Cys Trp Asp His Cys Ile 
 625                630                635                640
Lys Ile Tyr Ser Tyr His Leu Arg Arg Tyr Ser Thr Pro 
                 645                650



<210> 4739
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AA800803
<400> 4739

gacatttta  actgacttc  tttattgag  accagtgga  agcaggctg  agtacacta  60
agcagagat  aaccggccc  cccatctag  ggcgtacag  cggggagaa  ccaacagct  120
acagattcc  ctaccgggg  ttaggatga  acaggaagg  gatctttac  gcacctaac  180
cagtcacct  gggcagctg  ggcctgacc  ggggcagct  ggggtaagg  actgcaggg  240
aggggacat  taggggaag  cacagaggt  agatagcat  gggcccggg  aatgccaag  300
gctcagggc  cagaggcag  gtgggggag  tagtggcta  gatgtgagg  aaagctcca  360
tagaagctg  gtttctcca  agggctctg  ctcggccta  ccacagcat  cccaaagag  420
agagtctct  cacccagga  atagctgtt  gaaggagaa  gcctttagt  tggaaggat  480
tgctgtggt  cactagtat  tttgtggcc  tgctggggc  gatgctctg  gaaggttca  540
g  541



<210> 4740
<211> 859
<212> DNA
<213> Homo sapiens
<308> AK026608
<400> 4740

ggtctgcag  cgcgcgctc  cgaggtccc  cctcgcccg  tgagccggc  tgtaagcgc  60
gcggagatt  ggctagagg  ggaggcctg  gccacggcg  aggcgctgg  tccttctgg  120
actcctctg  tggaccgcc  ccatcggcc  cacttgccc  gctctccag  gattctgta  180
ctcctggct  cgtagtctc  cggacagct  tctttcctg  aagatgttt  tggtgggcc  240
gacaggggg  attgcctca  gcaagagct  agtgatcca  gtgttccag  agctgggct  300
tgcggtgat  gacgtggac  tgatggccc  gcacgtcgt  cagccagga  accctgccc  360
ccggcgcat  gtagaggtc  tcggcactg  ggtcttgct  gagaacggc  acataaatc  420
caaggtcct  ggggacctg  tctttaacc  gcctgaccg  cggcagctg  tcaacgcca  480
cacccaccc  gagattcgc  aggagatga  gaaggagac  ttcaagtac  tcctccggg  540
gccccgtac  agccccaga  gaaagaagc  cgttccctc  gctcttaag  aggctgaca  600
tttaatgag  agagacaca  gaggctttc  agccatgag  ccaggaagt  agttggttt  660
tctagtagg  atgggagta  taagagctg  tgaataatg  agccataga  ctgagttca  720
atcccaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  780
aaaaaaaaa  aaaaaaaaa  aaaaaaaag  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  840
aaaaaaaaa  aaaaaaaaa  859



<210> 4741
<211> 133
<212> PRT
<213> Homo sapiens
<308> AK026608
<400> 4741

Met Phe Leu Val Gly Leu Thr Gly Gly Ile Ala Ser Gly Lys Ser Ser 
  1               5                  10                  15
Val Ile Gln Val Phe Gln Gln Leu Gly Cys Ala Val Ile Asp Val Asp 
             20                  25                  30
Val Met Ala Arg His Val Val Gln Pro Gly Tyr Pro Ala His Arg Arg 
         35                  40                  45
Ile Val Glu Val Phe Gly Thr Glu Val Leu Leu Glu Asn Gly Asp Ile 
     50                  55                  60
Asn Arg Lys Val Leu Gly Asp Leu Ile Phe Asn Gln Pro Asp Arg Arg 
 65                  70                  75                  80
Gln Leu Leu Asn Ala Ile Thr His Pro Glu Ile Arg Lys Glu Met Met 
                 85                  90                  95
Lys Glu Thr Phe Lys Tyr Phe Leu Arg Glu Pro Arg Thr Ser Pro Arg 
             100                105                110
Gly Lys Lys His Val Pro Ser Ala Leu Lys Glu Ala Asp Ser Leu Met 
         115                120                125
Arg Arg Asp Thr Ter 
     130



<210> 4742
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AA800803
<400> 4742

gacatttta  actgacttc  tttattgag  accagtgga  agcaggctg  agtacacta  60
agcagagat  aaccggccc  cccatctag  ggcgtacag  cggggagaa  ccaacagct  120
acagattcc  ctaccgggg  ttaggatga  acaggaagg  gatctttac  gcacctaac  180
cagtcacct  gggcagctg  ggcctgacc  ggggcagct  ggggtaagg  actgcaggg  240
aggggacat  taggggaag  cacagaggt  agatagcat  gggcccggg  aatgccaag  300
gctcagggc  cagaggcag  gtgggggag  tagtggcta  gatgtgagg  aaagctcca  360
tagaagctg  gtttctcca  agggctctg  ctcggccta  ccacagcat  cccaaagag  420
agagtctct  cacccagga  atagctgtt  gaaggagaa  gcctttagt  tggaaggat  480
tgctgtggt  cactagtat  tttgtggcc  tgctggggc  gatgctctg  gaaggttca  540
g  541



<210> 4743
<211> 859
<212> DNA
<213> Homo sapiens
<308> AK026608
<400> 4743

ggtctgcag  cgcgcgctc  cgaggtccc  cctcgcccg  tgagccggc  tgtaagcgc  60
gcggagatt  ggctagagg  ggaggcctg  gccacggcg  aggcgctgg  tccttctgg  120
actcctctg  tggaccgcc  ccatcggcc  cacttgccc  gctctccag  gattctgta  180
ctcctggct  cgtagtctc  cggacagct  tctttcctg  aagatgttt  tggtgggcc  240
gacaggggg  attgcctca  gcaagagct  agtgatcca  gtgttccag  agctgggct  300
tgcggtgat  gacgtggac  tgatggccc  gcacgtcgt  cagccagga  accctgccc  360
ccggcgcat  gtagaggtc  tcggcactg  ggtcttgct  gagaacggc  acataaatc  420
caaggtcct  ggggacctg  tctttaacc  gcctgaccg  cggcagctg  tcaacgcca  480
cacccaccc  gagattcgc  aggagatga  gaaggagac  ttcaagtac  tcctccggg  540
gccccgtac  agccccaga  gaaagaagc  cgttccctc  gctcttaag  aggctgaca  600
tttaatgag  agagacaca  gaggctttc  agccatgag  ccaggaagt  agttggttt  660
tctagtagg  atgggagta  taagagctg  tgaataatg  agccataga  ctgagttca  720
atcccaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  780
aaaaaaaaa  aaaaaaaaa  aaaaaaaag  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  840
aaaaaaaaa  aaaaaaaaa  859



<210> 4744
<211> 133
<212> PRT
<213> Homo sapiens
<308> AK026608
<400> 4744

Met Phe Leu Val Gly Leu Thr Gly Gly Ile Ala Ser Gly Lys Ser Ser 
  1               5                  10                  15
Val Ile Gln Val Phe Gln Gln Leu Gly Cys Ala Val Ile Asp Val Asp 
             20                  25                  30
Val Met Ala Arg His Val Val Gln Pro Gly Tyr Pro Ala His Arg Arg 
         35                  40                  45
Ile Val Glu Val Phe Gly Thr Glu Val Leu Leu Glu Asn Gly Asp Ile 
     50                  55                  60
Asn Arg Lys Val Leu Gly Asp Leu Ile Phe Asn Gln Pro Asp Arg Arg 
 65                  70                  75                  80
Gln Leu Leu Asn Ala Ile Thr His Pro Glu Ile Arg Lys Glu Met Met 
                 85                  90                  95
Lys Glu Thr Phe Lys Tyr Phe Leu Arg Glu Pro Arg Thr Ser Pro Arg 
             100                105                110
Gly Lys Lys His Val Pro Ser Ala Leu Lys Glu Ala Asp Ser Leu Met 
         115                120                125
Arg Arg Asp Thr Ter 
     130



<210> 4745
<211> 497
<212> DNA
<213> Rattus norvegicus
<308> AA800814
<400> 4745

cttgtagag  cttttattt  tttgtttga  acagggtct  aaccactgt  acccctgga  60
ggcctggaa  tcactattt  gaccaagtt  accgctaac  tagaaatag  cctccgagt  120
ctgggatta  agcggtgaa  cacaatgtt  agctcggaa  tttgctagg  gaatgggga  180
catgaatgg  atggatgtc  aggcaccta  aatacattt  ttttctaga  agtaacaag  240
atttggacg  aatagtgag  tactggaaa  cgggcttct  gtacattga  gcaaggggc  300
tgaagagtt  tggccgagg  acacgtttt  cctatcaga  accgtgttc  ttcctcaaa  360
tgcctctag  tggtggtgc  gttctggat  cagtccagt  gataaggct  ggcacagtg  420
acaagaccc  tttaacaca  acaacaaaa  aatttgggg  catgtggga  atagacaca  480
aatagtcta  ttcttta  497



<210> 4746
<211> 470
<212> DNA
<213> Rattus norvegicus
<308> AA800850
<400> 4746

ggatgttaa  gtagttaca  caatataca  aaacaaaca  caacatagg  caacccacg  60
gaagagagg  gtgagacac  cacaatggg  ctgtacaaa  ttaggtcaa  ataaaggta  120
atgtatttt  tggggtcat  aaacattta  taggtcggt  gagaaagca  aagtaacag  180
aatatatgt  aaagtaatg  tttaatggc  atgagcaag  caaagcaat  gaattgtgc  240
tcttttgca  actgtagac  atgaaatgc  tagctacag  gtccataca  acatgaaac  300
attcatatg  aagaaacgt  ctcacagat  actggtggc  gataaacac  cgctaagtt  360
gaccaaagc  aactgagac  tggtagggt  attcatatt  taaactcaa  atgtttgct  420
tatttaaaa  tacctgtag  aactcatag  aaattgctt  tagttccaga  470



<210> 4747
<211> 3203
<212> DNA
<213> Homo sapiens
<308> L13689
<400> 4747

gagaggcag  gatcggggc  agacaatgg  gatgtgggc  cgggagccc  gttccggct  60
agcagcacc  cccagcccc  cagaataaa  ccgatcgcg  cccctccgc  cgcgccctc  120
cccgagtgc  gagcgggag  aggcggcgg  ggccgagga  gaggaggag  aggccccgg  180
ggaggaggc  ttggaggtc  aggcggagg  ggaggagga  gaggccgag  cgccggagg  240
ggccgaggc  ccggagcag  aggaggccg  ccggaggcg  catgagacg  gcgtggcgg  300
cgcggctgc  cggggccgc  ctggttgcc  attgacagc  gcgtctgca  ctcgcttca  360
gatggccgc  tggctcgca  tcattttct  ctgaacgac  tttaacttt  attgtcttt  420
ccgcccgct  cgatcgcct  gcgccggct  ctctttccg  gatttttta  caagcagaa  480
tgcatcgaa  aacgagaat  aagatcact  agctaaatc  ccacctgat  tgtgtgctt  540
gtggagggt  cttcattga  gccacaacc  taatagaat  tctacattc  ttctgtaaa  600
cttgtattg  tcgttacct  gagaccagc  agtattgtc  tatttgtga  gtccaagtt  660
acaagacca  accactact  aatataagg  cagataaaa  tctccaaga  attgtatac  720
aattagttc  agggctttt  aaaaatgaa  tgaagagaa  aagggattt  tatgcagct  780
atccttctg  tgatgctgc  aatggctct  atgaagata  aggagaggt  gcagatgaa  840
ataagagaa  tataactga  gatgagata  taagcttat  cattgaatt  tttgaccag  900
acagattgg  tcggaaagt  aacaaagac  aagagaaat  taaggagga  gtgaatgat  960
aaagatact  acgatgccc  gcagcaatg  ctgtgatgc  cttaagaaa  tttctcaga  1020
gtaaaatgg  catacctaa  actttccag  ttgatgtca  gtatgagga  gaaccttta  1080
aggattatt  tacactaat  gatattgcc  acatttata  ctggagaag  aatggtcca  1140
ttccattga  atacagagt  cgacctact  gtaaaagaa  gaagatcag  caccagaga  1200
atggactga  aaatgctgg  gaactggaa  gtgactctg  gagtgacaa  gccaacagc  1260
cagcaggag  agttccctc  acctcttct  gtttgccta  ccccagtac  ccagtgcag  1320
ctcctcatc  acagtttcc  cacatttcc  gtactatga  tggaaccag  aacagcccc  1380
gcggtaacc  ccaatcttc  tttgccaat  gacctcgaa  atcatcagt  aatgggtca  1440
cagcaactt  ttctggttg  tacctgaga  tgttaagga  aaaaatttt  aacccctga  1500
ttatataga  atcttcagc  attacgact  tctagagct  atacatgtg  ctatcgtcc  1560
atttgcttt  ttttgtagt  acattaaat  tggctataa  agatggact  catgtgata  1620
tcctgtccg  cttggttca  aagaaagat  gttgttata  agaattggt  tcttggaaa  1680
caggcaaga  tttttctct  tgttaggaa  gatgggaaa  ggtttctgt  accattgtt  1740
ggatttgga  gtactctgc  gtggacata  gcattgggc  atagtttgt  aatctcaac  1800
aacgcctac  ttacattct  cttgatcgt  cttgttatt  cgctgtttt  tgaacctgt  1860
gaaaaacaa  tgcttttta  cttgaaatt  aaccaacgg  aagaatatg  atagaataa  1920
gcattctat  atgccatgt  actgtgaat  acgatttct  gcagctatt  agccatttt  1980
attgctgtt  gatttatac  tctctgttg  tacgcaaaa  cgatcaaag  aaagtgaac  2040
tcagtttta  aatctgtat  cctaaaagc  ggtactacc  tttatttta  tgacttgtt  2100
aaatgattc  cttttgtaa  aatcagatg  cattatgct  gttgtacaa  gccatattg  2160
tatatgaca  aacaggaaa  agtattgta  gatatatct  taaatgcta  aaagaaata  2220
tgtgtttca  gcattcaga  atgattgtt  aaattctcc  aactggttc  acctttgca  2280
atacccata  cctatgttg  gccttgctt  ccagcaaag  atattttta  tgtggatat  2340
taattctaa  gtctgttcc  ttagaagca  ttggcacat  tttctatac  ttatatact  2400
ttctccagt  atacatgtt  actttaaaa  ttgttgcag  gaagaaaaa  ctttaactg  2460
gaaatatgg  aaccgtctt  attttccat  ggctatgat  gaattaata  tgtatttta  2520
aaatgcata  tgatcacta  aattctaaa  caatttttt  aataaacca  caggttgct  2580
aaagaaggc  ttttatcta  agttatttt  ataggtggt  tagcagtaa  tttaaattt  2640
agagttgct  ttacagtta  caatggaat  tgccttctc  gctatgtct  aaaatagaa  2700
ctatttatt  tgagcttct  caggtattt  taaatagag  aagcatgtt  aatttaaaa  2760
atgaataac  ccacccaac  attttcagt  tattttttg  tttggtcga  cttggtgtg  2820
gttcatcag  tatttgtga  ggtgtttat  ctatatgaa  attgtttca  gtttgtagg  2880
aaattgtag  taaacattt  attgtcccc  gtctgcaaa  gaagcacaa  tctattgct  2940
tgtcttgct  atagtcatt  aatcattac  tttacatat  ttgctgtta  ttctgcttt  3000
tttaaaaat  tagtaaagg  tgttttatg  agtcacaag  tacatatat  tttattttg  3060
cctaaattt  tacagtccc  ttgtaagtg  tgtttctaa  tatagatgt  aaatgaaat  3120
tcatttgta  ttggaaaaa  tccaataaa  aggatattc  tttagaaaa  agctaagat  3180
tttaataaa  atttgatat  aaa  3203



<210> 4748
<211> 326
<212> PRT
<213> Homo sapiens
<308> P35226
<400> 4748

Met His Arg Thr Thr Arg Ile Lys Ile Thr Glu Leu Asn Pro His Leu 
  1               5                  10                  15
Met Cys Val Leu Cys Gly Gly Tyr Phe Ile Asp Ala Thr Thr Ile Ile 
             20                  25                  30
Glu Cys Leu His Ser Phe Cys Lys Thr Cys Ile Val Arg Tyr Leu Glu 
         35                  40                  45
Thr Ser Lys Tyr Cys Pro Ile Cys Asp Val Gln Val His Lys Thr Arg 
     50                  55                  60
Pro Leu Leu Asn Ile Arg Ser Asp Lys Thr Leu Gln Asp Ile Val Tyr 
 65                  70                  75                  80
Lys Leu Val Pro Gly Leu Phe Lys Asn Glu Met Lys Arg Arg Arg Asp 
                 85                  90                  95
Phe Tyr Ala Ala His Pro Ser Ala Asp Ala Ala Asn Gly Ser Asn Glu 
             100                105                110
Asp Arg Gly Glu Val Ala Asp Glu Asp Lys Arg Ile Ile Thr Asp Asp 
         115                120                125
Glu Ile Ile Ser Leu Ser Ile Glu Phe Phe Asp Gln Asn Arg Leu Asp 
     130                135                140
Arg Lys Val Asn Lys Asp Lys Glu Lys Ser Lys Glu Glu Val Asn Asp 
 145                150                155                160
Lys Arg Tyr Leu Arg Cys Pro Ala Ala Met Thr Val Met His Leu Arg 
                 165                170                175
Lys Phe Leu Arg Ser Lys Met Asp Ile Pro Asn Thr Phe Gln Ile Asp 
             180                185                190
Val Met Tyr Glu Glu Glu Pro Leu Lys Asp Tyr Tyr Thr Leu Met Asp 
         195                200                205
Ile Ala Tyr Ile Tyr Thr Trp Arg Arg Asn Gly Pro Leu Pro Leu Lys 
     210                215                220
Tyr Arg Val Arg Pro Thr Cys Lys Arg Met Lys Ile Ser His Gln Arg 
 225                230                235                240
Asp Gly Leu Thr Asn Ala Gly Glu Leu Glu Ser Asp Ser Gly Ser Asp 
                 245                250                255
Lys Ala Asn Ser Pro Ala Gly Gly Val Pro Ser Thr Ser Ser Cys Leu 
             260                265                270
Pro Ser Pro Ser Thr Pro Val Gln Ser Pro His Pro Gln Phe Pro His 
         275                280                285
Ile Ser Ser Thr Met Asn Gly Thr Ser Asn Ser Pro Ser Gly Asn His 
     290                295                300
Gln Ser Ser Phe Ala Asn Arg Pro Arg Lys Ser Ser Val Asn Gly Ser 
 305                310                315                320
Ser Ala Thr Ser Ser Gly 
                 325



<210> 4749
<211> 379
<212> DNA
<213> Rattus norvegicus
<308> AA800882
<400> 4749

ggaagttta  aaatgtatt  cagaatcag  aaaacatca  atccacttt  cagggcacg  60
atctcaagc  aagagttca  aacagtctc  ggcagatcc  acgccaaaa  cccgtgaca  120
gccttctta  caaacagct  gacacttga  agataacac  gactccagc  tgcttcgcc  180
tcttgggcc  tctgaggtt  tgtttatgc  tgtggaatt  aataggatc  gagcaaagc  240
actctgcag  aacaaacga  tttagggag  ataaatgct  gcctacttt  ctgaagact  300
caggagagt  actggtctt  tgttgttag  tcagggtca  gattaaacc  gaatacttt  360
ttgaaaact  tgggaacca  379



<210> 4750
<211> 182
<212> DNA
<213> Homo sapiens
<308> AA708838
<400> 4750

ttttttttt  ttttttttt  tttttttta  tcaaatttt  ttggaagtt  acaaatgta  60
tacagacat  agtaaaaca  catatccat  ttacagggc  cggatctca  gcaaagtgt  120
cagaacagt  tctggcaga  ccacaccaa  ggcctgttg  agaccttct  aacaaatag  180
tt  182



<210> 4751
<211> 297
<212> DNA
<213> Rattus norvegicus
<308> AA800908
<400> 4751

aagtaacta  aatcgaact  atttttgct  aagtaaata  gctaaaaat  aggaaatac  60
accaacaag  aaataaatg  tcaaagcac  aaaattcta  taggtaact  tttggttag  120
ttagacggg  attagcaac  aagtttagg  ctcaaaatg  ctcgataga  ttccagctg  180
agataggtc  tttactaac  ttgataaaa  ctaagttta  acgtactgt  tcatatttt  240
ttaaatgtg  acgtactca  gtggatcat  caaacgtcc  actctcaaa  aataaat  297



<210> 4752
<211> 460
<212> DNA
<213> Rattus norvegicus
<308> AA800928
<400> 4752

aaaaaaaaa  gttaaaata  attacacct  ccttcacca  cagtacatg  atacagtgt  60
gttactatg  ctccgggac  ttcagctta  gacatctca  aggagccag  ctctttctc  120
caccccgag  ccggtgtgg  ctctgcaac  gctttgagg  tggcggacg  atggacaca  180
acctctcac  gtcataacg  gggggctct  gccctatta  gccccttgg  aaacgaaca  240
ggcaagggg  ggggctgag  caggtaatc  gctgagctg  gaactccat  tctcctgcc  300
cacacctga  acctgcggg  gtctctctc  ccctcgcta  acaaaggac  agctgagtt  360
ggaggacaa  agagtgccc  acagacaga  ctccatccc  acggcaggg  ccctgttct  420
tactggctc  gggtataaa  gaaaagaca  ttcgttaaaa  460



<210> 4753
<211> 495
<212> DNA
<213> Rattus norvegicus
<308> AA800962
<400> 4753

catagagtc  cctttattg  agcttgacc  gttgggttt  taaccctca  gctccacag  60
tagctgggg  agggataga  tatcaaaaa  ggatgagtt  agctgctgt  gctgtgggg  120
ttggctgga  gctgctggc  ggttggagc  gctggagcc  tggcagggt  aaactgagg  180
atggcagcg  taataatac  cttggagcg  taatactct  gaggggaca  gcacttggg  240
ccctaaggt  cgaaggcac  tggagtcag  gagaggaca  ggcttgcaa  gggactggg  300
aggaccagg  ccggggttt  gcaggcact  tggggagtg  tggggttgg  agcttgggc  360
ctgagcagc  cagaaggct  tggtagtgg  aggcacagt  tctgggctg  gtctgcatt  420
aatacaggg  tttcctcag  gctcgtctc  aagctctga  ggcaagaac  tgtactgct  480
ctgccggat  tgggc  495



<210> 4754
<211> 2541
<212> PRT
<213> Rattus norvegicus
<308> NP_035732
<400> 4754

Met Val Ala Leu Ser Leu Lys Ile Ser Ile Gly Asn Val Val Lys Thr 
  1               5                  10                  15
Met Gln Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg Met Ile 
             20                  25                  30
Arg Glu Arg Ile Pro Glu Ala Leu Ala Gly Pro Pro Asn Asp Phe Gly 
         35                  40                  45
Leu Phe Leu Ser Asp Asp Asp Pro Lys Lys Gly Ile Trp Leu Glu Ala 
     50                  55                  60
Gly Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu 
 65                  70                  75                  80
Tyr Arg Lys Lys Gln Arg Pro Leu Lys Ile Arg Met Leu Asp Gly Thr 
                 85                  90                  95
Val Lys Thr Ile Met Val Asp Asp Ser Lys Thr Val Thr Asp Met Leu 
             100                105                110
Met Thr Ile Cys Ala Arg Ile Gly Ile Thr Asn His Asp Glu Tyr Ser 
         115                120                125
Leu Val Arg Glu Leu Met Glu Glu Lys Lys Asp Glu Gly Thr Gly Thr 
     130                135                140
Leu Arg Lys Asp Lys Thr Leu Leu Arg Asp Glu Lys Lys Met Glu Lys 
 145                150                155                160
Leu Lys Gln Lys Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His 
                 165                170                175
Gly Arg Thr Leu Arg Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu 
             180                185                190
Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg Asp 
         195                200                205
Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp Ile Leu 
     210                215                220
Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu Phe Ala Gly 
 225                230                235                240
Phe Gln Cys Gln Ile Gln Phe Gly Pro His Asn Glu Gln Lys His Lys 
                 245                250                255
Ala Gly Phe Leu Asp Leu Lys Asp Phe Leu Pro Lys Glu Tyr Val Lys 
             260                265                270
Gln Lys Gly Glu Arg Lys Ile Phe Gln Ala His Lys Asn Cys Gly Gln 
         275                280                285
Met Ser Glu Ile Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser 
     290                295                300
Leu Lys Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys 
 305                310                315                320
Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr Lys Glu Cys 
                 325                330                335
Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Ile Gln Glu Trp Ser 
             340                345                350
Leu Thr Asn Ile Lys Arg Trp Ala Ala Ser Pro Lys Ser Phe Thr Leu 
         355                360                365
Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Val Gln Thr Thr Glu 
     370                375                380
Gly Glu Gln Ile Ala Gln Leu Ile Ala Gly Tyr Ile Asp Ile Ile Leu 
 385                390                395                400
Lys Lys Lys Lys Ser Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu 
                 405                410                415
Ser Thr Met Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu 
             420                425                430
Gln Gln Gln Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala 
         435                440                445
Leu Pro Ala Ile Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln 
     450                455                460
Val Gly Ser Met Pro Pro Ala Gln Gln Gln Ile Thr Ser Gly Gln Met 
 465                470                475                480
His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln Ala Leu Thr 
                 485                490                495
Gly Thr Ile Asn Ser Ser Met Gln Ala Val Gln Ala Ala Gln Ala Thr 
             500                505                510
Leu Asp Asp Phe Glu Thr Leu Pro Pro Leu Gly Gln Asp Ala Ala Ser 
         515                520                525
Lys Ala Trp Arg Lys Asn Lys Met Asp Glu Ser Lys His Glu Ile His 
     530                535                540
Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val Val Asn Leu 
 545                550                555                560
Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala 
                 565                570                575
Val Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val Lys 
             580                585                590
Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Asn Gly Arg Pro Leu 
         595                600                605
Leu Gln Ala Ala Lys Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg 
     610                615                620
Ser Ala Gln Pro Ala Ser Ala Glu Pro Arg Gln Asn Leu Leu Gln Ala 
 625                630                635                640
Ala Gly Asn Val Gly Gln Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly 
                 645                650                655
Glu Ser Asp Thr Asp Pro His Phe Gln Asp Val Leu Met Gln Leu Ala 
             660                665                670
Asn Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser 
         675                680                685
Val Ala Gln Arg Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala 
     690                695                700
Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys Thr 
 705                710                715                720
Lys Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys Gln Glu Gln Leu 
                 725                730                735
Val Glu Ala Gly Arg Leu Val Ala Lys Ala Val Glu Gly Cys Val Ser 
             740                745                750
Ala Ser Gln Ala Ala Thr Glu Asp Gly Gln Leu Leu Arg Gly Val Gly 
         755                760                765
Ala Ala Ala Thr Ala Val Thr Gln Ala Leu Asn Glu Leu Leu Gln His 
     770                775                780
Val Lys Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gln 
 785                790                795                800
Ala Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe Ser Ser Met 
                 805                810                815
Gly Asp Ala Gly Glu Met Val Arg Gln Ala Arg Ile Leu Ala Gln Ala 
             820                825                830
Thr Ser Asp Leu Val Asn Ala Ile Lys Ala Asp Ala Glu Gly Glu Ser 
         835                840                845
Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala Lys Ile Leu Ala 
     850                855                860
Asp Ala Thr Ala Lys Met Val Glu Ala Ala Lys Gly Ala Ala Ala His 
 865                870                875                880
Pro Asp Ser Glu Glu Gln Gln Gln Arg Leu Arg Glu Ala Ala Glu Gly 
                 885                890                895
Leu Arg Met Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile Lys Lys Lys 
             900                905                910
Leu Val Gln Arg Leu Glu His Ala Ala Lys Gln Ala Ala Ala Ser Ala 
         915                920                925
Thr Gln Thr Ile Ala Ala Ala Gln His Ala Ala Ser Ala Pro Lys Ala 
     930                935                940
Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys Ala Val Ala 
 945                950                955                960
Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg Gly Ser Gln Ala Gln 
                 965                970                975
Pro Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile Ala Ala Ser Gln Ser 
             980                985                990
Phe Leu Gln Pro Gly Gly Lys Met Val Ala Ala Ala Lys Ala Ser Val 
         995                1000                1005
Pro Thr Ile Gln Asp Gln Ala Ser Ala Met Gln Leu Ser Gln Cys Ala 
     1010                1015                1020
Lys Asn Leu Gly Thr Ala Leu Ala Glu Leu Arg Thr Ala Ala Gln Lys 
 1025                1030                1035                1040
Ala Gln Glu Ala Cys Gly Pro Leu Glu Met Asp Ser Ala Leu Ser Val 
                 1045                1050                1055
Val Gln Asn Leu Glu Lys Asp Leu Gln Glu Ile Lys Ala Ala Ala Arg 
             1060                1065                1070
Asp Gly Lys Leu Lys Pro Leu Pro Gly Glu Thr Met Glu Lys Cys Thr 
         1075                1080                1085
Gln Asp Leu Gly Asn Ser Thr Lys Ala Val Ser Ser Ala Ile Ala Lys 
     1090                1095                1100
Leu Leu Gly Glu Ile Ala Gln Gly Asn Glu Asn Tyr Ala Gly Ile Ala 
 1105                1110                1115                1120
Ala Arg Asp Val Ala Gly Gly Leu Arg Ser Leu Ala Gln Ala Ala Arg 
                 1125                1130                1135
Gly Val Ala Ala Leu Thr Ser Asp Pro Ala Val Gln Ala Ile Val Leu 
             1140                1145                1150
Asp Thr Ala Ser Asp Val Leu Asp Lys Ala Ser Ser Leu Ile Glu Glu 
         1155                1160                1165
Ala Lys Lys Ala Ser Gly His Pro Gly Asp Pro Glu Ser Gln Gln Arg 
     1170                1175                1180
Leu Ala Gln Val Ala Lys Ala Val Thr Gln Ala Leu Asn Arg Cys Val 
 1185                1190                1195                1200
Ser Cys Leu Pro Gly Gln Arg Asp Val Asp Asn Ala Leu Arg Ala Val 
                 1205                1210                1215
Gly Asp Ala Ser Lys Arg Leu Leu Ser Asp Leu Leu Pro Pro Ser Thr 
             1220                1225                1230
Gly Thr Phe Gln Glu Ala Gln Ser Arg Leu Asn Glu Ala Ala Ala Gly 
         1235                1240                1245
Leu Asn Gln Ala Ala Thr Glu Leu Val Gln Ala Ser Arg Gly Thr Pro 
     1250                1255                1260
Gln Asp Leu Ala Arg Ala Ser Gly Arg Phe Gly Gln Asp Phe Ser Thr 
 1265                1270                1275                1280
Phe Leu Glu Ala Gly Val Glu Met Ala Gly Gln Ala Pro Ser Gln Glu 
                 1285                1290                1295
Asp Arg Ala Gln Val Val Ser Asn Leu Lys Gly Ile Ser Met Ser Ser 
             1300                1305                1310
Ser Lys Leu Leu Leu Ala Ala Lys Ala Leu Ser Thr Asp Pro Ala Ser 
         1315                1320                1325
Pro Asn Leu Lys Ser Gln Leu Ala Ala Ala Ala Arg Ala Val Thr Asp 
     1330                1335                1340
Ser Ile Asn Gln Leu Ile Thr Met Cys Thr Gln Gln Ala Pro Gly Gln 
 1345                1350                1355                1360
Lys Glu Cys Asp Asn Ala Leu Arg Gln Leu Glu Thr Val Arg Glu Leu 
                 1365                1370                1375
Leu Glu Asn Pro Val Gln Pro Ile Asn Asp Met Ser Tyr Phe Gly Cys 
             1380                1385                1390
Leu Asp Ser Val Met Glu Asn Ser Lys Val Leu Gly Glu Ala Met Thr 
         1395                1400                1405
Gly Ile Ser Gln Asn Ala Lys Asn Gly Asn Leu Pro Glu Phe Gly Asp 
     1410                1415                1420
Ala Ile Ala Thr Ala Ser Lys Ala Leu Cys Gly Phe Thr Glu Ala Ala 
 1425                1430                1435                1440
Ala Gln Ala Ala Tyr Leu Val Gly Val Ser Asp Pro Asn Ser Gln Ala 
                 1445                1450                1455
Gly Gln Gln Gly Leu Val Glu Pro Thr Gln Phe Ala Arg Ala Asn Gln 
             1460                1465                1470
Ala Ile Gln Met Ala Cys Gln Ser Leu Gly Glu Pro Gly Cys Thr Gln 
         1475                1480                1485
Ala Gln Val Leu Ser Ala Ala Thr Ile Val Ala Lys His Thr Ser Ala 
     1490                1495                1500
Leu Cys Asn Ser Cys Arg Leu Ala Ser Ala Arg Thr Ala Asn Pro Thr 
 1505                1510                1515                1520
Ala Lys Arg Gln Phe Val Gln Ser Ala Lys Glu Val Ala Asn Ser Thr 
                 1525                1530                1535
Ala Asn Leu Val Lys Thr Ile Lys Ala Leu Asp Gly Asp Phe Thr Glu 
             1540                1545                1550
Glu Asn Arg Ala Gln Cys Arg Ala Ala Thr Ala Pro Leu Leu Glu Ala 
         1555                1560                1565
Val Asp Asn Leu Ser Ala Phe Ala Ser Asn Pro Glu Phe Ser Ser Val 
     1570                1575                1580
Pro Ala Gln Ile Ser Pro Glu Gly Arg Ala Ala Met Glu Pro Ile Val 
 1585                1590                1595                1600
Ile Ser Ala Lys Thr Met Leu Glu Ser Ala Gly Gly Leu Ile Gln Thr 
                 1605                1610                1615
Ala Arg Ala Leu Ala Val Asn Pro Arg Asp Pro Pro Arg Trp Ser Val 
             1620                1625                1630
Leu Ala Gly His Ser Arg Thr Val Ser Asp Ser Ile Lys Lys Leu Ile 
         1635                1640                1645
Thr Ser Met Arg Asp Lys Ala Pro Gly Gln Leu Glu Cys Glu Thr Ala 
     1650                1655                1660
Ile Ala Ala Leu Asn Ser Cys Leu Arg Asp Leu Asp Gln Ala Ser Leu 
 1665                1670                1675                1680
Ala Ala Val Ser Gln Gln Leu Ala Pro Arg Glu Gly Ile Ser Gln Glu 
                 1685                1690                1695
Ala Leu His Thr Gln Met Leu Thr Ala Val Gln Glu Ile Ser His Leu 
             1700                1705                1710
Ile Glu Pro Leu Ala Ser Ala Ala Arg Ala Glu Ala Ser Gln Leu Gly 
         1715                1720                1725
His Lys Val Ser Gln Met Ala Gln Tyr Phe Glu Pro Leu Thr Leu Ala 
     1730                1735                1740
Ala Val Gly Ala Ala Ser Lys Thr Leu Ser His Pro Gln Gln Met Ala 
 1745                1750                1755                1760
Leu Leu Asp Gln Thr Lys Thr Leu Ala Glu Ser Ala Leu Gln Leu Leu 
                 1765                1770                1775
Tyr Thr Ala Lys Glu Ala Gly Gly Asn Pro Lys Gln Ala Ala His Thr 
             1780                1785                1790
Gln Glu Ala Leu Glu Glu Ala Val Gln Met Met Thr Glu Ala Val Glu 
         1795                1800                1805
Asp Leu Thr Thr Thr Leu Asn Glu Ala Ala Ser Ala Ala Gly Val Val 
     1810                1815                1820
Gly Gly Met Val Asp Ser Ile Thr Gln Ala Ile Asn Gln Leu Asp Glu 
 1825                1830                1835                1840
Gly Pro Met Gly Asp Pro Glu Gly Ser Phe Val Asp Tyr Gln Thr Thr 
                 1845                1850                1855
Met Val Arg Thr Ala Lys Ala Ile Ala Val Thr Val Gln Glu Met Val 
             1860                1865                1870
Thr Lys Ser Asn Thr Ser Pro Glu Glu Leu Gly Pro Leu Ala Asn Gln 
         1875                1880                1885
Leu Thr Ser Asp Tyr Gly Arg Leu Ala Ser Gln Ala Lys Pro Ala Ala 
     1890                1895                1900
Val Ala Ala Glu Asn Glu Glu Ile Gly Ala His Ile Lys His Arg Val 
 1905                1910                1915                1920
Gln Glu Leu Gly His Gly Cys Ser Ala Leu Val Thr Lys Ala Gly Ala 
                 1925                1930                1935
Leu Gln Cys Ser Pro Ser Asp Val Tyr Thr Lys Lys Glu Leu Ile Glu 
             1940                1945                1950
Cys Ala Arg Arg Val Ser Glu Lys Val Ser His Val Leu Ala Ala Leu 
         1955                1960                1965
Gln Ala Gly Asn Arg Gly Thr Gln Ala Cys Ile Thr Ala Ala Ser Ala 
     1970                1975                1980
Val Ser Gly Ile Ile Ala Asp Leu Asp Thr Thr Ile Met Phe Ala Thr 
 1985                1990                1995                2000
Ala Gly Thr Leu Asn Arg Glu Gly Ala Glu Thr Phe Ala Asp His Arg 
                 2005                2010                2015
Glu Gly Ile Leu Lys Thr Ala Lys Val Leu Val Glu Asp Thr Lys Val 
             2020                2025                2030
Leu Val Gln Asn Ala Ala Gly Ser Gln Glu Lys Leu Ala Gln Ala Ala 
         2035                2040                2045
Gln Ser Ser Val Ala Thr Ile Thr Arg Leu Ala Asp Val Val Lys Leu 
     2050                2055                2060
Gly Ala Ala Ser Leu Gly Ala Glu Asp Pro Glu Thr Gln Val Val Leu 
 2065                2070                2075                2080
Ile Asn Ala Val Lys Asp Val Ala Lys Ala Leu Gly Asp Leu Ile Ser 
                 2085                2090                2095
Ala Thr Lys Ala Ala Ala Gly Lys Val Gly Asp Asp Pro Ala Val Trp 
             2100                2105                2110
Gln Leu Lys Asn Ser Ala Lys Val Met Val Thr Asn Val Thr Ser Leu 
         2115                2120                2125
Leu Lys Thr Val Lys Ala Val Glu Asp Glu Ala Thr Lys Gly Thr Arg 
     2130                2135                2140
Ala Leu Glu Ala Thr Thr Glu His Ile Arg Gln Glu Leu Ala Val Phe 
 2145                2150                2155                2160
Cys Ser Pro Glu Pro Pro Ala Lys Thr Ser Thr Pro Glu Asp Phe Ile 
                 2165                2170                2175
Arg Met Thr Lys Gly Ile Thr Met Ala Thr Ala Lys Ala Val Ala Ala 
             2180                2185                2190
Gly Asn Ser Cys Arg Gln Glu Asp Val Ile Ala Thr Ala Asn Leu Ser 
         2195                2200                2205
Arg Arg Ala Ile Ala Asp Met Leu Arg Ala Cys Lys Glu Ala Ala Phe 
     2210                2215                2220
His Pro Glu Val Ala Pro Asp Val Arg Leu Arg Ala Leu His Tyr Gly 
 2225                2230                2235                2240
Arg Glu Cys Ala Asn Gly Tyr Leu Glu Leu Leu Asp His Val Leu Leu 
                 2245                2250                2255
Thr Leu Gln Lys Pro Asn Pro Asp Leu Lys Gln Gln Leu Thr Gly His 
             2260                2265                2270
Ser Lys Arg Val Ala Gly Ser Val Thr Glu Leu Ile Gln Ala Ala Glu 
         2275                2280                2285
Ala Met Lys Gly Thr Glu Trp Val Asp Pro Glu Asp Pro Thr Val Ile 
     2290                2295                2300
Ala Glu Asn Glu Leu Leu Gly Ala Ala Ala Ala Ile Glu Ala Ala Ala 
 2305                2310                2315                2320
Lys Lys Leu Glu Gln Leu Lys Pro Arg Ala Lys Pro Lys Glu Ala Asp 
                 2325                2330                2335
Glu Ser Leu Asn Phe Glu Glu Gln Ile Leu Glu Ala Ala Lys Ser Ile 
             2340                2345                2350
Ala Ala Ala Thr Ser Ala Leu Val Lys Ala Ala Ser Ala Ala Gln Arg 
         2355                2360                2365
Glu Leu Val Ala Gln Gly Lys Val Gly Ala Ile Pro Ala Asn Ala Leu 
     2370                2375                2380
Asp Asp Gly Gln Trp Ser Gln Gly Leu Ile Ser Ala Ala Arg Met Val 
 2385                2390                2395                2400
Ala Ala Ala Thr Asn Asn Leu Cys Glu Ala Ala Asn Ala Ala Val Gln 
                 2405                2410                2415
Gly His Ala Ser Gln Glu Lys Leu Ile Ser Ser Ala Lys Gln Val Ala 
             2420                2425                2430
Ala Ser Thr Ala Gln Leu Leu Val Ala Cys Lys Val Lys Ala Asp Gln 
         2435                2440                2445
Asp Ser Glu Ala Met Lys Arg Leu Gln Ala Ala Gly Asn Ala Val Lys 
     2450                2455                2460
Arg Ala Ser Asp Asn Leu Val Lys Ala Ala Gln Lys Ala Ala Ala Phe 
 2465                2470                2475                2480
Glu Asp Gln Glu Asn Glu Thr Val Val Val Lys Glu Lys Met Val Gly 
                 2485                2490                2495
Gly Ile Ala Gln Ile Ile Ala Ala Gln Glu Glu Met Leu Arg Lys Glu 
             2500                2505                2510
Arg Glu Leu Glu Glu Ala Arg Lys Lys Leu Ala Gln Ile Arg Gln Gln 
         2515                2520                2525
Gln Tyr Lys Phe Leu Pro Ser Glu Leu Arg Asp Glu His 
     2530                2535                2540



<210> 4755
<211> 8168
<212> DNA
<213> Homo sapiens
<308> AF177198
<400> 4755

cccgagaag  ggcggggcg  cgggccggc  ggcggggcg  agagccagg  agcgcaggt  60
tagccaggc  ggagaaaag  agctgccac  atggttgca  tttcactga  gatcagcat  120
gggaatgtg  tgaagacga  gcagtttga  ccgtctacc  tggtgtacg  cgcctgccg  180
atcattcgt  agcggatcc  agaggcccc  gctggtcct  ccagcgact  tgggctctt  240
ctgtcagat  atgacccca  aaagggtat  tggctggag  ctgggaaag  tttggacta  300
tacatgctc  gaaatgggg  cactatgga  tacaggaag  aacagagac  cctgaagat  360
cgtatgctg  atggaactg  gaagacgat  atggtggat  actctaaga  tgtcactga  420
atgctcatg  ccatctgtg  ccgcattgg  atcaccaat  atgatgaat  ttcattggt  480
cgagagctg  tggaagaga  aaaggagga  ataacaggg  ccttaagaa  ggacaagac  540
ttgctgcga  atgaaaaga  gatggagaa  ctaaagcag  aattgcaca  agatgatga  600
ttgaactgg  tggaccatg  tcggacact  agggagcag  gtgtagagg  gcacgagac  660
ctgctgctg  ggaggaagt  cttttactc  gaccagaat  tggattccc  ggaccctgt  720
cagctgaac  tcctgtatg  gcaggcacg  gatgacatc  tgaatggct  ccaccctgt  780
tcctttgac  aggcctgtg  gtttgctgg  ttccaatgc  agatccagt  tgggcccca  840
aatgagcag  agcacaagg  tggcttcct  gacctgaag  acttcctgc  caaggagta  900
gtgaagcag  agggagagc  taagatctt  caggcacac  agaattgtg  gcagatgag  960
gagattgag  ccaaggtcc  ctacgtgaa  ctagcccgt  ctctcaaga  ttacggtgt  1020
tccttcttc  tggtgaagg  aaaaatgaa  gggaagaac  agctagtgc  caggcttct  1080
ggcatcacc  aggagtgtg  gatgcgagt  gatgagaag  ccaaggaag  gatccagga  1140
tggaacctc  ccaacatca  acgctgggc  gcgtctccc  aaagcttca  cctggattt  1200
ggagattac  aagatggct  ttactcagt  cagacaact  aaggggagc  gattgcaca  1260
ctcattgcc  gctacatcg  tatcatcct  aagaagaaa  aaagcaagg  tcactttgg  1320
ctggaagga  atgaggagt  tactatgct  gaggactca  tgtccccca  aaagtcaac  1380
gtcctgcag  agcaataca  ccgggtggg  aaagtggag  atggctctg  ggccctgcc  1440
gccatcatg  gctctggag  ctctggtcc  gagaatttc  aggtgggca  catgccccc  1500
gcccagcag  agattacca  cggccagat  caccgagga  acatgcctc  tctgacttc  1560
gcccagcag  cactcactg  aaccattaa  tccagcatg  aggccgtgc  ggctgccca  1620
gccaccctg  atgactttg  cactctgcc  cctcttggc  aggatgctg  ctctaaggc  1680
tggcgtaaa  acaagatgg  tgaatcaaa  catgagatc  actctcagg  agatgccat  1740
acagctggt  ctgcgtctg  ggtgaacct  acagcaggg  accctgctg  gacagacta  1800
accgcagtg  gctgtgcag  caccacaat  tcctccaac  tgacggaga  gtcccgtgg  1860
gtgaagctg  tggctgcct  gctggagga  gaaggcggc  gtggtcggc  cctgttgca  1920
gcagcaaag  gccttgcgg  agcagtgtc  gaactgctg  gcagtgccc  accagccag  1980
gctgagccc  gtcagaacc  gctgcaagc  gctgggaac  tgggccagg  cagtgggga  2040
ctgttgcaa  aaattgggg  aagtgatac  gacccccac  tccaggatg  gctaatgca  2100
ctcgccaaa  ctgtggcaa  tgctgcagc  gccctggtc  tcaaggcca  gagtgtggc  2160
cagcggaca  aggactcgg  acttcagac  caagttatt  ctgcagcaa  acagtgtgc  2220
ctatccact  cccaactag  ggcctgtac  aaggtggtg  cacctacaa  cagctcacc  2280
gtctgccaa  agcaactgg  ggaggctgg  cgactggta  ccaaagccg  ggagggctg  2340
gtgtctgcc  cccaggcag  tacagagga  gggcaactg  tgcgagggg  aggagcagc  2400
gccacagct  tcacccagg  cctaaatga  ctgctgcag  atgtgaaag  ccatgccac  2460
ggggctggg  ctgctggcc  ttatgacca  gctactgac  ccatcctaa  cgtcactga  2520
aacatcttt  gctccatgg  tgatgctgg  gagatggtg  gacaggccc  catcctggc  2580
caagccaca  ctgacctgg  caatgccat  aaggctgat  ctgaggggg  aagtgatct  2640
gagaactcc  gcaagctct  aagtgctgc  aagatccta  ctgatgcca  agccaagat  2700
gtagaggct  ccaagggag  agctgccca  cctgacagt  aggagcagc  gcagcggct  2760
cgggaggca  ctgaggggc  gcgcatggc  accaatgca  ctgcgcaga  tgccatcaa  2820
aaaaagctg  tgcagcgcc  ggagcatgc  gccaagcag  ctgcagcct  agccacaca  2880
accatcgct  cagctcagc  cgcagcctc  acccccaaa  cctctgccg  cccccagcc  2940
ctgctggtg  agagctgca  ggcagtggc  gagcagatt  cactgctgg  gcagggcgt  3000
cgaggaagc  aagcccagc  tgacagccc  agcgctcag  ttgccctca  tgctgccag  3060
cagagcttc  tgcagccag  tgggaagat  gtggcagct  caaaggcct  agtgccaac  3120
attcaggac  aggcttcag  catgcagct  agtcagtgt  ccaagaacc  gggcaccgc  3180
ctggctgaa  tccggacgg  tgcccagaa  gctcaggaa  catgtggac  tttggagat  3240
gattctgca  tgagtgtgg  acagaatct  gagaaagat  tacaggaag  gaaggcagc  3300
gctcgagat  gcaagctta  acccttacc  ggggagaca  tggagaagt  tacccagga  3360
ctgggcaac  gcaccaaag  cgtgagctc  gccatcgcc  agctactgg  agaggttgc  3420
cagggcaat  agaattatg  aggtattgc  gctcgggat  tggcaggtg  gctgcggtc  3480
ctggcccag  ccgctaggg  agtcgctgc  ctgacgtca  atcctgcag  gcaggccat  3540
gtacttgat  cggccagtg  tgtgctgga  aaggccagc  gcctcattg  ggaggcgaa  3600
aaggcagct  gccatccag  ggaccctga  agccagcag  ggcttgccc  ggtggctaa  3660
gcagtgacc  aggctctga  ccgctgtgt  agctgccta  ctggccagc  cgatgtgga  3720
aatgccctg  gggcagttg  agatgccag  aagcgactc  tgagtgact  gcttcctcc  3780
agcactggg  catttcaag  agctcagag  cggttgaat  aagctgctg  tgggctgaa  3840
caggcagcc  cagaactgg  gcaggcctc  cggggaacc  ctcaggacc  ggctcgagc  3900
tcaggccga  ttggacagg  cttcagcac  ttcctggaa  ctggtgtgg  gatggcagg  3960
caggctccg  gccaggagg  ccgagccca  gttgtgtcc  acttgaagg  catctccat  4020
tcttcaagc  aacttcttc  ggctgccaa  gccctgtcc  cggaccctg  tgcccctaa  4080
ctcaagagt  agctggctg  agctgccag  gcagtaact  acagcatca  tcagctcat  4140
actatgtgc  cccagcagg  acccggcca  aaggagtgt  ataacgccc  gcgggaatt  4200
gagacggtc  gggaactcc  ggagaaccc  gtccagccc  tcaatgaca  gtcctactt  4260
ggttgcctg  acagtgtaa  ggagaactc  aaggtgctg  gcgaggcca  gactggcat  4320
tcccaaaat  ccaagaacg  aaacctgcc  gagtttgga  atgccattt  cacagcctc  4380
aaggcactt  gtggcttca  cgaggcagc  gcacaggct  catatctgg  tggtgtctc  4440
gaccccaat  gccaagctg  acagcaagg  ctagtggag  ccacacagt  tgcccgtgc  4500
aaccaggca  ttcagatgg  ctgccagag  ttgggagag  ctggctgta  ccaggccca  4560
gtgctctct  cagccacca  tgtggctaa  cacacctct  cactgtgta  cagctgtcg  4620
ctggcttct  cccgtacca  caatcctac  gccaagcgc  agtttgtac  gtcagccaa  4680
gaggtggcc  acagcacag  taatcttgt  aagaccatc  aggcgctag  tgggccttt  4740
acagaggag  accgtgccc  gtgccgagc  gcaacagcc  ctctgctgg  ggctgtgga  4800
aatctgagt  cctttgcgt  caaccctga  ttctccagc  ttcctgccc  gatcagccc  4860
gagggtcgg  ctgccatgg  gcccattgt  atctctgcc  agacaatgt  agagagtgc  4920
gggggactc  tccagacag  ccgggccct  gcagtcaac  cccgggacc  cccgagctg  4980
tcggtgctg  ccggccact  ccgtactgt  tcagactcc  tcaagaagc  aattacaag  5040
atgagggac  aggctccag  gcagctgga  tgtgaaacg  ccattgcag  tctgaacag  5100
tgtctacgg  acctagacc  ggcttccct  gctgcagtc  gccagcagc  tgctccccg  5160
gagggaatc  ctcaagagg  cttgcacac  gagatgctg  ctgcagtcc  agagatctc  5220
catctcatt  agccgctgg  ccatgctgc  cgggctgaa  cctcccagc  gggacacaa  5280
gtgtcccag  tggcgcagt  ctttgagcc  ctcaccctg  ctgcagtgg  tgctgcctc  5340
aagaccctg  gccacccgc  gcagatggc  ctcctggac  agactaaaa  attggcaga  5400
tctgccctg  agttgctat  cactgccaa  gaggctggt  gtaacccaa  gcaagcagc  5460
cacacccag  aagccctgg  ggaggctgt  cagatgatg  ccgaggccg  agaggacct  5520
acaacaacc  tcaacgagg  agccagtgc  gctggggtc  tgggtggca  ggtggactc  5580
atcacccag  ccatcaacc  gctagatga  ggaccaatg  gtgaaccag  aggttcctt  5640
gtggattac  aaacaacta  ggtgcggac  gccaaggcc  ttgcagtga  tgttcagga  5700
atggttacc  agtcaaaca  cagcccaga  gagctgggc  ctcttgcta  ccagctgac  5760
agtgactat  gccgtctgg  ctcggaggc  aagcctgca  cggtggctg  tgaaaatga  5820
gagataggt  cccatatca  acaccgggt  caggagctg  gccatggct  tgccgctct  5880
gtcaccaag  caggcgccc  gcagtgcag  cccagtgat  cctacacca  gaaggagct  5940
atagagtgt  cccggagag  ctctgagaa  gtctcccac  tcctggctg  gctccaggc  6000
gggaatcgt  gcacccagg  ctgcatcac  gcagccagc  ctgtgtctg  tatcattgc  6060
gacctcgac  ccaccatca  gttcgccac  gctggcacg  tcaatcgtg  gggtactga  6120
actttcgct  accaccggg  gggcatcct  aagactgcg  aggtgctgg  ggaggacac  6180
aaggtcctg  tgcaaaacg  agctgggag  caggagaag  tggcgcagg  tgcccagtc  6240
tccgtggcg  ccatcaccc  cctcgctga  gtggtcaag  tgggtgcag  cagcctggg  6300
gctgaggac  ctgagaccc  ggtggtact  atcaacgca  tgaaagatg  agccaaagc  6360
ctgggagac  tcatcagtg  aacgaaggc  gcagctggc  aagttggag  tgaccctgc  6420
gtgtggcag  taaagaact  tgccaaggt  atggtgacc  atgtgacat  attgcttaa  6480
acagtaaaa  ccgtggaag  tgaggccac  aaaggcact  gggccctgg  ggcaaccac  6540
gaacacata  ggcaggagc  ggcggtttt  tgttcccca  agccacctg  caagacctc  6600
accccagaa  acttcatcc  aatgaccaa  ggtatcacc  tggcaaccg  caaggccgt  6660
gctgctggc  attcctgtc  ccaggaaga  gtcattgcc  cagccaatc  gagccgccg  6720
gctattgca  atatgcttc  ggcttgcaa  gaagcagct  accacccag  agtggcccc  6780
gatgtgcgg  ttcgagccc  gcactatgg  cgggagtgt  ccaatggct  cctggaact  6840
ctggaccat  tactgctga  cctgcagaa  ccaagccca  aactcaagc  gcagttgac  6900
ggacattca  agcgtgtgg  tggttccgt  actgagctc  tccaggctg  tgaagccat  6960
aagggaaca  aatgggtag  cccagagga  cccacagtc  ttgctgaga  tgagctcct  7020
ggagctgca  ccgccattg  ggctgcagc  aaaaagcta  agcagctga  gccccgggc  7080
aaacccaag  aggcagatg  gtccttgaa  tttgaggag  agatactag  agctgccaa  7140
tccattgca  cagccacca  tgcactggt  aaggctgcg  cggctgccc  gagagaact  7200
gtggcccaa  ggaaggtgg  tgccattcc  gccaatgca  tggacgatg  gcagtggtc  7260
cagggcctc  tttctgctg  ccggatggt  gctgcggcc  ccaacaatc  gtgtgaggc  7320
gccaatgca  ctgtacaag  ccatgccag  caggagaag  tcatctcat  agccaagca  7380
gtagctgcc  ccacagccc  gctccttgt  gcctgcaag  tcaaggctg  ccaggactc  7440
gaggcaatg  aacgacttc  ggctgctgg  aacgcagtg  agcgagcct  agataatct  7500
gtgaaagca  cacagaagg  tgcagcctt  gaagagcag  agaatgaga  agtggtggt  7560
aaagagaag  tggttggcg  cattgccca  atcatcgca  cacaggaag  aatgcttcg  7620
aaggaacga  agctggaag  ggcgcggaa  aaactggcc  agatccggc  gcagcagta  7680
aagtttctg  cttcagagc  tcgagatga  cactaaaga  gcctcttct  tttaatgca  7740
acccggccc  gagactgtg  gtgccacta  caaagcctt  tgggctgtc  gggcccaac  7800
tgcccaacc  cagcactcc  caaagtgcc  gccaaaccc  aaggcctgg  cccgcccag  7860
cccgcagta  atcccctgt  ccctcccca  ccccaagtg  cttcatgcc  tagggcccc  7920
caagtgcct  cccctcccc  gagtattaa  gctccaaga  tattattaa  gctgctgta  7980
ctcgatctg  atctgccgg  gccccagcc  actccaccc  gccagcagc  tccagccag  8040
ccccacagc  tcatcagct  tcttcaccg  tttttgata  tatcttccc  cacccccag  8100
tacccatag  ggctgcaga  ttataagcc  caaacaggt  atgctccaa  aaaaatgat  8160
ctacctac  8168



<210> 4756
<211> 2541
<212> PRT
<213> Homo sapiens
<308> Q9Y490
<400> 4756

Met Val Ala Leu Ser Leu Lys Ile Ser Ile Gly Asn Val Val Lys Thr 
  1               5                  10                  15
Met Gln Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg Ile Ile 
             20                  25                  30
Arg Glu Arg Ile Pro Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly 
         35                  40                  45
Leu Phe Leu Ser Asp Asp Asp Pro Lys Lys Gly Ile Trp Leu Glu Ala 
     50                  55                  60
Gly Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu 
 65                  70                  75                  80
Tyr Arg Lys Lys Gln Arg Pro Leu Lys Ile Arg Met Leu Asp Gly Thr 
                 85                  90                  95
Val Lys Thr Ile Met Val Asp Asp Ser Lys Thr Val Thr Asp Met Leu 
             100                105                110
Met Thr Ile Cys Ala Arg Ile Gly Ile Thr Asn His Asp Glu Tyr Ser 
         115                120                125
Leu Val Arg Glu Leu Met Glu Glu Lys Lys Glu Glu Ile Thr Gly Thr 
     130                135                140
Leu Arg Lys Asp Lys Thr Leu Leu Arg Asp Glu Lys Lys Met Glu Lys 
 145                150                155                160
Leu Lys Gln Lys Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His 
                 165                170                175
Gly Arg Thr Leu Arg Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu 
             180                185                190
Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg Asp 
         195                200                205
Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp Ile Leu 
     210                215                220
Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu Phe Ala Gly 
 225                230                235                240
Phe Gln Cys Gln Ile Gln Phe Gly Pro His Asn Glu Gln Lys His Lys 
                 245                250                255
Ala Gly Phe Leu Asp Leu Lys Asp Phe Leu Pro Lys Glu Tyr Val Lys 
             260                265                270
Gln Lys Gly Glu Arg Lys Ile Phe Gln Ala His Lys Asn Cys Gly Gln 
         275                280                285
Met Ser Glu Ile Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser 
     290                295                300
Leu Lys Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys 
 305                310                315                320
Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr Lys Glu Cys 
                 325                330                335
Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Ile Gln Glu Trp Asn 
             340                345                350
Leu Thr Asn Ile Lys Arg Trp Ala Ala Ser Pro Lys Ser Phe Thr Leu 
         355                360                365
Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Val Gln Thr Thr Glu 
     370                375                380
Gly Glu Gln Ile Ala Gln Leu Ile Ala Gly Tyr Ile Asp Ile Ile Leu 
 385                390                395                400
Lys Lys Lys Lys Ser Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu 
                 405                410                415
Ser Thr Met Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu 
             420                425                430
Gln Gln Gln Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala 
         435                440                445
Leu Pro Ala Ile Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln 
     450                455                460
Val Gly Ser Met Pro Pro Ala Gln Gln Gln Ile Thr Ser Gly Gln Met 
 465                470                475                480
His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln Ala Leu Thr 
                 485                490                495
Gly Thr Ile Asn Ser Ser Met Gln Ala Val Gln Ala Ala Gln Ala Thr 
             500                505                510
Leu Asp Asp Phe Asp Thr Leu Pro Pro Leu Gly Gln Asp Ala Ala Ser 
         515                520                525
Lys Ala Trp Arg Lys Asn Lys Met Asp Glu Ser Lys His Glu Ile His 
     530                535                540
Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val Val Asn Leu 
 545                550                555                560
Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala 
                 565                570                575
Val Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val Lys 
             580                585                590
Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly Arg Pro Leu 
         595                600                605
Leu Gln Ala Ala Lys Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg 
     610                615                620
Ser Ala Gln Pro Ala Ser Ala Glu Pro Arg Gln Asn Leu Leu Gln Ala 
 625                630                635                640
Ala Gly Asn Val Gly Gln Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly 
                 645                650                655
Glu Ser Asp Thr Asp Pro His Phe Gln Asp Ala Leu Met Gln Leu Ala 
             660                665                670
Lys Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser 
         675                680                685
Val Ala Gln Arg Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala 
     690                695                700
Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys Thr 
 705                710                715                720
Lys Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys Gln Glu Gln Leu 
                 725                730                735
Val Glu Ala Gly Arg Leu Val Ala Lys Ala Val Glu Gly Cys Val Ser 
             740                745                750
Ala Ser Gln Ala Ala Thr Glu Asp Gly Gln Leu Leu Arg Gly Val Gly 
         755                760                765
Ala Ala Ala Thr Ala Val Thr Gln Ala Leu Asn Glu Leu Leu Gln His 
     770                775                780
Val Lys Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gln 
 785                790                795                800
Ala Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe Ser Ser Met 
                 805                810                815
Gly Asp Ala Gly Glu Met Val Gly Gln Ala Arg Ile Leu Ala Gln Ala 
             820                825                830
Thr Ser Asp Leu Val Asn Ala Ile Lys Ala Asp Ala Glu Gly Glu Ser 
         835                840                845
Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala Lys Ile Leu Ala 
     850                855                860
Asp Ala Thr Ala Lys Met Val Glu Ala Ala Lys Gly Ala Ala Ala His 
 865                870                875                880
Pro Asp Ser Glu Glu Gln Gln Gln Arg Leu Arg Glu Ala Ala Glu Gly 
                 885                890                895
Leu Arg Met Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile Lys Lys Lys 
             900                905                910
Leu Val Gln Arg Leu Glu His Ala Ala Lys Gln Ala Ala Ala Ser Ala 
         915                920                925
Thr Gln Thr Ile Ala Ala Ala Gln His Ala Ala Ser Thr Pro Lys Ala 
     930                935                940
Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys Ala Val Ala 
 945                950                955                960
Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg Gly Ser Gln Ala Gln 
                 965                970                975
Pro Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile Ala Ala Ser Gln Ser 
             980                985                990
Phe Leu Gln Pro Gly Gly Lys Met Val Ala Ala Ala Lys Ala Ser Val 
         995                1000                1005
Pro Thr Ile Gln Asp Gln Ala Ser Ala Met Gln Leu Ser Gln Cys Ala 
     1010                1015                1020
Lys Asn Leu Gly Thr Ala Leu Ala Glu Leu Arg Thr Ala Ala Gln Lys 
 1025                1030                1035                1040
Ala Gln Glu Ala Cys Gly Pro Leu Glu Met Asp Ser Ala Leu Ser Val 
                 1045                1050                1055
Val Gln Asn Leu Glu Lys Asp Leu Gln Glu Val Lys Ala Ala Ala Arg 
             1060                1065                1070
Asp Gly Lys Leu Lys Pro Leu Pro Gly Glu Thr Met Glu Lys Cys Thr 
         1075                1080                1085
Gln Asp Leu Gly Asn Ser Thr Lys Ala Val Ser Ser Ala Ile Ala Gln 
     1090                1095                1100
Leu Leu Gly Glu Val Ala Gln Gly Asn Glu Asn Tyr Ala Gly Ile Ala 
 1105                1110                1115                1120
Ala Arg Asp Val Ala Gly Gly Leu Arg Ser Leu Ala Gln Ala Ala Arg 
                 1125                1130                1135
Gly Val Ala Ala Leu Thr Ser Asp Pro Ala Val Gln Ala Ile Val Leu 
             1140                1145                1150
Asp Thr Ala Ser Asp Val Leu Asp Lys Ala Ser Ser Leu Ile Glu Glu 
         1155                1160                1165
Ala Lys Lys Ala Ala Gly His Pro Gly Asp Pro Glu Ser Gln Gln Arg 
     1170                1175                1180
Leu Ala Gln Val Ala Lys Ala Val Thr Gln Ala Leu Asn Arg Cys Val 
 1185                1190                1195                1200
Ser Cys Leu Pro Gly Gln Arg Asp Val Asp Asn Ala Leu Arg Ala Val 
                 1205                1210                1215
Gly Asp Ala Ser Lys Arg Leu Leu Ser Asp Ser Leu Pro Pro Ser Thr 
             1220                1225                1230
Gly Thr Phe Gln Glu Ala Gln Ser Arg Leu Asn Glu Ala Ala Ala Gly 
         1235                1240                1245
Leu Asn Gln Ala Ala Thr Glu Leu Val Gln Ala Ser Arg Gly Thr Pro 
     1250                1255                1260
Gln Asp Leu Ala Arg Ala Ser Gly Arg Phe Gly Gln Asp Phe Ser Thr 
 1265                1270                1275                1280
Phe Leu Glu Ala Gly Val Glu Met Ala Gly Gln Ala Pro Ser Gln Glu 
                 1285                1290                1295
Asp Arg Ala Gln Val Val Ser Asn Leu Lys Gly Ile Ser Met Ser Ser 
             1300                1305                1310
Ser Lys Leu Leu Leu Ala Ala Lys Ala Leu Ser Thr Asp Pro Ala Ala 
         1315                1320                1325
Pro Asn Leu Lys Ser Gln Leu Ala Ala Ala Ala Arg Ala Val Thr Asp 
     1330                1335                1340
Ser Ile Asn Gln Leu Ile Thr Met Cys Thr Gln Gln Ala Pro Gly Gln 
 1345                1350                1355                1360
Lys Glu Cys Asp Asn Ala Leu Arg Glu Leu Glu Thr Val Arg Glu Leu 
                 1365                1370                1375
Leu Glu Asn Pro Val Gln Pro Ile Asn Asp Met Ser Tyr Phe Gly Cys 
             1380                1385                1390
Leu Asp Ser Val Met Glu Asn Ser Lys Val Leu Gly Glu Ala Met Thr 
         1395                1400                1405
Gly Ile Ser Gln Asn Ala Lys Asn Gly Asn Leu Pro Glu Phe Gly Asp 
     1410                1415                1420
Ala Ile Ser Thr Ala Ser Lys Ala Leu Cys Gly Phe Thr Glu Ala Ala 
 1425                1430                1435                1440
Ala Gln Ala Ala Tyr Leu Val Gly Val Ser Asp Pro Asn Ser Gln Ala 
                 1445                1450                1455
Gly Gln Gln Gly Leu Val Glu Pro Thr Gln Phe Ala Arg Ala Asn Gln 
             1460                1465                1470
Ala Ile Gln Met Ala Cys Gln Ser Leu Gly Glu Pro Gly Cys Thr Gln 
         1475                1480                1485
Ala Gln Val Leu Ser Ala Ala Thr Ile Val Ala Lys His Thr Ser Ala 
     1490                1495                1500
Leu Cys Asn Ser Cys Arg Leu Ala Ser Ala Arg Thr Thr Asn Pro Thr 
 1505                1510                1515                1520
Ala Lys Arg Gln Phe Val Gln Ser Ala Lys Glu Val Ala Asn Ser Thr 
                 1525                1530                1535
Ala Asn Leu Val Lys Thr Ile Lys Ala Leu Asp Gly Pro Phe Thr Glu 
             1540                1545                1550
Glu Asn Arg Ala Gln Cys Arg Ala Ala Thr Ala Pro Leu Leu Glu Ala 
         1555                1560                1565
Val Asp Asn Leu Ser Ala Phe Ala Ser Asn Pro Glu Phe Ser Ser Ile 
     1570                1575                1580
Pro Ala Gln Ile Ser Pro Glu Gly Arg Ala Ala Met Glu Pro Ile Val 
 1585                1590                1595                1600
Ile Ser Ala Gln Thr Met Leu Glu Ser Ala Gly Gly Leu Ile Gln Thr 
                 1605                1610                1615
Ala Arg Ala Leu Ala Val Asn Pro Arg Asp Pro Pro Ser Trp Ser Val 
             1620                1625                1630
Leu Ala Gly His Ser Arg Thr Val Ser Asp Ser Ile Lys Lys Leu Ile 
         1635                1640                1645
Thr Ser Met Arg Asp Lys Ala Pro Gly Gln Leu Glu Cys Glu Thr Ala 
     1650                1655                1660
Ile Ala Ala Leu Asn Ser Cys Leu Arg Asp Leu Asp Gln Ala Ser Leu 
 1665                1670                1675                1680
Ala Ala Val Ser Gln Gln Leu Ala Pro Arg Glu Gly Ile Ser Gln Glu 
                 1685                1690                1695
Ala Leu His Thr Glu Met Leu Thr Ala Val Gln Glu Ile Ser His Leu 
             1700                1705                1710
Ile Glu Pro Leu Ala His Ala Ala Arg Ala Glu Ala Ser Gln Leu Gly 
         1715                1720                1725
His Lys Val Ser Gln Met Ala Gln Tyr Phe Glu Pro Leu Thr Leu Ala 
     1730                1735                1740
Ala Val Gly Ala Ala Ser Lys Thr Leu Ser His Pro Gln Gln Met Ala 
 1745                1750                1755                1760
Leu Leu Asp Gln Thr Lys Thr Leu Ala Glu Ser Ala Leu Gln Leu Leu 
                 1765                1770                1775
Tyr Thr Ala Lys Glu Ala Gly Gly Asn Pro Lys Gln Ala Ala His Thr 
             1780                1785                1790
Gln Glu Ala Leu Glu Glu Ala Val Gln Met Met Thr Glu Ala Val Glu 
         1795                1800                1805
Asp Leu Thr Thr Thr Leu Asn Glu Ala Ala Ser Ala Ala Gly Val Val 
     1810                1815                1820
Gly Gly Met Val Asp Ser Ile Thr Gln Ala Ile Asn Gln Leu Asp Glu 
 1825                1830                1835                1840
Gly Pro Met Gly Glu Pro Glu Gly Ser Phe Val Asp Tyr Gln Thr Thr 
                 1845                1850                1855
Met Val Arg Thr Ala Lys Ala Ile Ala Val Thr Val Gln Glu Met Val 
             1860                1865                1870
Thr Lys Ser Asn Thr Ser Pro Glu Glu Leu Gly Pro Leu Ala Asn Gln 
         1875                1880                1885
Leu Thr Ser Asp Tyr Gly Arg Leu Ala Ser Glu Ala Lys Pro Ala Ala 
     1890                1895                1900
Val Ala Ala Glu Asn Glu Glu Ile Gly Ser His Ile Lys His Arg Val 
 1905                1910                1915                1920
Gln Glu Leu Gly His Gly Cys Ala Ala Leu Val Thr Lys Ala Gly Ala 
                 1925                1930                1935
Leu Gln Cys Ser Pro Ser Asp Ala Tyr Thr Lys Lys Glu Leu Ile Glu 
             1940                1945                1950
Cys Ala Arg Arg Val Ser Glu Lys Val Ser His Val Leu Ala Ala Leu 
         1955                1960                1965
Gln Ala Gly Asn Arg Gly Thr Gln Ala Cys Ile Thr Ala Ala Ser Ala 
     1970                1975                1980
Val Ser Gly Ile Ile Ala Asp Leu Asp Thr Thr Ile Met Phe Ala Thr 
 1985                1990                1995                2000
Ala Gly Thr Leu Asn Arg Glu Gly Thr Glu Thr Phe Ala Asp His Arg 
                 2005                2010                2015
Glu Gly Ile Leu Lys Thr Ala Lys Val Leu Val Glu Asp Thr Lys Val 
             2020                2025                2030
Leu Val Gln Asn Ala Ala Gly Ser Gln Glu Lys Leu Ala Gln Ala Ala 
         2035                2040                2045
Gln Ser Ser Val Ala Thr Ile Thr Arg Leu Ala Asp Val Val Lys Leu 
     2050                2055                2060
Gly Ala Ala Ser Leu Gly Ala Glu Asp Pro Glu Thr Gln Val Val Leu 
 2065                2070                2075                2080
Ile Asn Ala Val Lys Asp Val Ala Lys Ala Leu Gly Asp Leu Ile Ser 
                 2085                2090                2095
Ala Thr Lys Ala Ala Ala Gly Lys Val Gly Asp Asp Pro Ala Val Trp 
             2100                2105                2110
Gln Leu Lys Asn Ser Ala Lys Val Met Val Thr Asn Val Thr Ser Leu 
         2115                2120                2125
Leu Lys Thr Val Lys Ala Val Glu Asp Glu Ala Thr Lys Gly Thr Arg 
     2130                2135                2140
Ala Leu Glu Ala Thr Thr Glu His Ile Arg Gln Glu Leu Ala Val Phe 
 2145                2150                2155                2160
Cys Ser Pro Glu Pro Pro Ala Lys Thr Ser Thr Pro Glu Asp Phe Ile 
                 2165                2170                2175
Arg Met Thr Lys Gly Ile Thr Met Ala Thr Ala Lys Ala Val Ala Ala 
             2180                2185                2190
Gly Asn Ser Cys Arg Gln Glu Asp Val Ile Ala Thr Ala Asn Leu Ser 
         2195                2200                2205
Arg Arg Ala Ile Ala Asp Met Leu Arg Ala Cys Lys Glu Ala Ala Tyr 
     2210                2215                2220
His Pro Glu Val Ala Pro Asp Val Arg Leu Arg Ala Leu His Tyr Gly 
 2225                2230                2235                2240
Arg Glu Cys Ala Asn Gly Tyr Leu Glu Leu Leu Asp His Val Leu Leu 
                 2245                2250                2255
Thr Leu Gln Lys Pro Ser Pro Glu Leu Lys Gln Gln Leu Thr Gly His 
             2260                2265                2270
Ser Lys Arg Val Ala Gly Ser Val Thr Glu Leu Ile Gln Ala Ala Glu 
         2275                2280                2285
Ala Met Lys Gly Thr Glu Trp Val Asp Pro Glu Asp Pro Thr Val Ile 
     2290                2295                2300
Ala Glu Asn Glu Leu Leu Gly Ala Ala Ala Ala Ile Glu Ala Ala Ala 
 2305                2310                2315                2320
Lys Lys Leu Glu Gln Leu Lys Pro Arg Ala Lys Pro Lys Glu Ala Asp 
                 2325                2330                2335
Glu Ser Leu Asn Phe Glu Glu Gln Ile Leu Glu Ala Ala Lys Ser Ile 
             2340                2345                2350
Ala Ala Ala Thr Ser Ala Leu Val Lys Ala Ala Ser Ala Ala Gln Arg 
         2355                2360                2365
Glu Leu Val Ala Gln Gly Lys Val Gly Ala Ile Pro Ala Asn Ala Leu 
     2370                2375                2380
Asp Asp Gly Gln Trp Ser Gln Gly Leu Ile Ser Ala Ala Arg Met Val 
 2385                2390                2395                2400
Ala Ala Ala Thr Asn Asn Leu Cys Glu Ala Ala Asn Ala Ala Val Gln 
                 2405                2410                2415
Gly His Ala Ser Gln Glu Lys Leu Ile Ser Ser Ala Lys Gln Val Ala 
             2420                2425                2430
Ala Ser Thr Ala Gln Leu Leu Val Ala Cys Lys Val Lys Ala Asp Gln 
         2435                2440                2445
Asp Ser Glu Ala Met Lys Arg Leu Gln Ala Ala Gly Asn Ala Val Lys 
     2450                2455                2460
Arg Ala Ser Asp Asn Leu Val Lys Ala Ala Gln Lys Ala Ala Ala Phe 
 2465                2470                2475                2480
Glu Glu Gln Glu Asn Glu Thr Val Val Val Lys Glu Lys Met Val Gly 
                 2485                2490                2495
Gly Ile Ala Gln Ile Ile Ala Ala Gln Glu Glu Met Leu Arg Lys Glu 
             2500                2505                2510
Arg Glu Leu Glu Glu Ala Arg Lys Lys Leu Ala Gln Ile Arg Gln Gln 
         2515                2520                2525
Gln Tyr Lys Phe Leu Pro Ser Glu Leu Arg Asp Glu His 
     2530                2535                2540



<210> 4757
<211> 613
<212> DNA
<213> Rattus norvegicus
<308> AA801130
<400> 4757

aagaagtca  tggagttta  tcacagtta  tcactacct  ccaaattgc  attcgcaga  60
gttagaggc  taagtacat  ggtttgttt  tttatttaa  cactgatct  taaatatat  120
cacacaaaa  ttagttcag  aaggcttca  gatatacac  aattccaaa  taaaacaat  180
aaatggccc  ggtgtaact  cagagataa  tttttatca  cagcaggga  agaggcagc  240
gaaccagga  gggtgggaa  aggctccgc  caggacgcc  ccggggcct  aggggtgct  300
cgagctgag  ccatctcac  aaacagagt  cagggggga  cccaccctc  agagtccag  360
agcccacgg  cgccgccaa  tccaaggga  agcctggga  tagccatga  tctgctgtg  420
ggaggaggc  gcgtggaga  aaacggtgg  caggcacat  actacggag  actgagagc  480
cacaggaga  aagatttaa  aagctttgc  ttgctcttg  tcttttcta  ctcaaaagg  540
ttcatggga  ggggcagca  agcagctgc  aacaccact  ttgtgcaca  agatgcaac  600
atgcaacca  ccc  613



<210> 4758
<211> 217
<212> PRT
<213> Rattus norvegicus
<308> P29354
<400> 4758

Met Glu Ala Ile Ala Lys Tyr Asp Phe Lys Ala Thr Ala Asp Asp Glu 
  1               5                  10                  15
Leu Ser Phe Lys Arg Gly Asp Ile Leu Lys Val Leu Asn Glu Glu Cys 
             20                  25                  30
Asp Gln Asn Trp Tyr Lys Ala Glu Leu Asn Gly Lys Asp Gly Phe Ile 
         35                  40                  45
Pro Lys Asn Tyr Ile Glu Met Lys Pro His Pro Trp Phe Phe Gly Lys 
     50                  55                  60
Ile Pro Arg Ala Lys Ala Glu Glu Met Leu Ser Lys Gln Arg His Asp 
 65                  70                  75                  80
Gly Ala Phe Leu Ile Arg Glu Ser Glu Ser Ala Pro Gly Asp Phe Ser 
                 85                  90                  95
Leu Ser Val Lys Phe Gly Asn Asp Val Gln His Phe Lys Val Leu Arg 
             100                105                110
Asp Gly Ala Gly Lys Tyr Phe Leu Trp Val Val Lys Phe Asn Ser Leu 
         115                120                125
Asn Glu Leu Val Asp Tyr His Arg Ser Thr Ser Val Ser Arg Asn Gln 
     130                135                140
Gln Ile Phe Leu Arg Asp Ile Glu Gln Val Pro Gln Gln Pro Thr Tyr 
 145                150                155                160
Val Gln Ala Leu Phe Asp Phe Asp Pro Gln Glu Asp Gly Glu Leu Gly 
                 165                170                175
Phe Arg Arg Gly Asp Phe Ile His Val Met Asp Asn Ser Asp Pro Asn 
             180                185                190
Trp Trp Lys Gly Ala Cys His Gly Gln Thr Gly Met Phe Pro Arg Asn 
         195                200                205
Tyr Val Thr Pro Val Asn Arg Asn Val 
     210                215



<210> 4759
<211> 1356
<212> DNA
<213> Homo sapiens
<308> BC000631
<400> 4759

ggcacgagg  accgggcgg  ggcagcggc  gcggcggct  tggcagagt  tgtgcctgt  60
gcggtgacg  cggcgggag  aagcgctgc  ctcgcagag  agccttggg  tcgccggcc  120
ctcgcagcg  tgtggaggg  cgggccgga  gctgagcgg  gcagctgcg  cacgggtgg  180
attgtgtgt  ccagagtgc  ggagcgagt  ccagaagag  ggcgaggct  agcccagag  240
gctgggttg  ttcagcagg  aagactccc  tccccctgc  tcaggctgc  gagcactga  300
cagcgctca  aatggaagc  atcgccaaa  atgacttca  agctactgc  gacgacgag  360
tgagcttca  aagggggga  atcctcaag  ttttgaacg  agaatgtga  cagaactgg  420
acaaggcag  gcttaatgg  aaagacggc  tcattccca  gaactacat  gaaatgaaa  480
cacatccgt  gttttttgg  aaaatcccc  gagccaagg  agaagaaat  cttagcaaa  540
agcggcacg  tggggcctt  cttatccga  agagtgaga  cgctcctgg  gacttctcc  600
tctctgtca  gtttggaaa  gatgtgcag  acttcaagg  gctccgaga  ggagccggg  660
agtacttcc  ctgggtggt  aagttcaat  ctttgaatg  gctggtgga  tatcacaga  720
ctacatctg  ctccagaaa  cagcagata  tcctgcggg  catagaaca  gtgccacag  780
agccgacat  cgtccaggc  ctctttgac  ttgatcccc  ggaggatgg  gagctgggc  840
tccgccggg  agattttat  catgtcatg  ataactcag  ccccaactg  tggaaagga  900
cttgccacg  gcagaccgg  atgtttccc  gcaattatg  cacccccgt  aaccggaac  960
tctaagagt  aagaagcaa  tatttaaag  aagtgaaaa  tgtaaaaca  atacaaaag  1020
attaaaccc  caagctgcc  ctgacagca  cctgtgagg  agtgcagaa  acctggccg  1080
gtcaccctg  gaccctctc  ctttggttg  aactttagg  ggtgggagg  ggcgttgga  1140
ttaaaaatg  caaaactta  ctataaatt  agaagagtt  ttattacaa  ttttcactg  1200
tgctcctct  tcccctcct  tgtcttttt  ttcatcctt  tttctcttc  gtccatcag  1260
gcatgacgt  taaggccac  tatagtcct  gctgacgcc  ataataaaa  acaagaaac  1320
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaa  1356



<210> 4760
<211> 217
<212> PRT
<213> Homo sapiens
<308> P29354
<400> 4760

Met Glu Ala Ile Ala Lys Tyr Asp Phe Lys Ala Thr Ala Asp Asp Glu 
  1               5                  10                  15
Leu Ser Phe Lys Arg Gly Asp Ile Leu Lys Val Leu Asn Glu Glu Cys 
             20                  25                  30
Asp Gln Asn Trp Tyr Lys Ala Glu Leu Asn Gly Lys Asp Gly Phe Ile 
         35                  40                  45
Pro Lys Asn Tyr Ile Glu Met Lys Pro His Pro Trp Phe Phe Gly Lys 
     50                  55                  60
Ile Pro Arg Ala Lys Ala Glu Glu Met Leu Ser Lys Gln Arg His Asp 
 65                  70                  75                  80
Gly Ala Phe Leu Ile Arg Glu Ser Glu Ser Ala Pro Gly Asp Phe Ser 
                 85                  90                  95
Leu Ser Val Lys Phe Gly Asn Asp Val Gln His Phe Lys Val Leu Arg 
             100                105                110
Asp Gly Ala Gly Lys Tyr Phe Leu Trp Val Val Lys Phe Asn Ser Leu 
         115                120                125
Asn Glu Leu Val Asp Tyr His Arg Ser Thr Ser Val Ser Arg Asn Gln 
     130                135                140
Gln Ile Phe Leu Arg Asp Ile Glu Gln Val Pro Gln Gln Pro Thr Tyr 
 145                150                155                160
Val Gln Ala Leu Phe Asp Phe Asp Pro Gln Glu Asp Gly Glu Leu Gly 
                 165                170                175
Phe Arg Arg Gly Asp Phe Ile His Val Met Asp Asn Ser Asp Pro Asn 
             180                185                190
Trp Trp Lys Gly Ala Cys His Gly Gln Thr Gly Met Phe Pro Arg Asn 
         195                200                205
Tyr Val Thr Pro Val Asn Arg Asn Val 
     210                215



<210> 4761
<211> 635
<212> DNA
<213> Rattus norvegicus
<308> AA817843
<400> 4761

ttttttttt  tttttttga  ctctaccct  atattttat  aaaagggta  taaacatta  60
gaattaacc  agctgctta  ttgaattac  aaataacat  attcaatat  aaaataaga  120
actgtctac  aatctctga  agtaataaa  cgcaatata  aatgcatac  ggcgtcaca  180
agcaacaca  tctcgtaca  aacaaaaat  tttttaata  ctttaaaat  caatttttt  240
cttttaaaa  cattcatga  aaagattct  aagtcagaa  taacacctc  attagtcag  300
catcaggaa  ctacgttac  gctacttat  atacaagga  gcggcctca  tctcacttc  360
tcccaatgc  tctgctcca  actccgtca  actctcgct  gcgctctcc  cacagcccg  420
ctccatcct  ccttcatat  atgaaaact  aatctgctg  acaccagaa  tctgttgat  480
ggacgtcgt  taaaccata  cgttttgtt  ttggccatc  gcagttatt  acccagccg  540
taactggtt  gtgaatgcc  cttccgtga  ctcctcgct  agtccatct  tatcagaca  600
ggccccacc  atgcccttc  ctcacttca  ggcct  635



<210> 4762
<211> 207
<212> PRT
<213> Rattus norvegicus
<308> P22569
<400> 4762

Met Thr Met Asp Gly Asp Ser Ser Thr Thr Asp Ala Ser Gln Leu Gly 
  1               5                  10                  15
Ile Ser Ala Asp Tyr Ile Gly Gly Ser His Tyr Val Ile Gln Pro His 
             20                  25                  30
Asp Asp Thr Glu Asp Ser Met Asn Asp His Glu Asp Thr Asn Gly Ser 
         35                  40                  45
Lys Glu Ser Phe Arg Glu Gln Asp Ile Tyr Leu Pro Ile Ala Asn Val 
     50                  55                  60
Ala Arg Ile Met Lys Asn Ala Ile Pro Gln Thr Gly Lys Ile Ala Lys 
 65                  70                  75                  80
Asp Ala Lys Glu Cys Val Gln Glu Cys Val Ser Glu Phe Ile Ser Phe 
                 85                  90                  95
Ile Thr Ser Glu Ala Ser Glu Arg Cys His Gln Glu Lys Arg Lys Thr 
             100                105                110
Ile Asn Gly Glu Asp Ile Leu Phe Ala Met Ser Thr Leu Gly Phe Asp 
         115                120                125
Ser Tyr Val Glu Pro Leu Lys Leu Tyr Leu Gln Lys Phe Arg Glu Ala 
     130                135                140
Met Lys Gly Glu Lys Gly Ile Gly Gly Ala Val Ser Ala Thr Asp Gly 
 145                150                155                160
Leu Ser Glu Glu Leu Thr Glu Glu Ala Phe Thr Asn Gln Leu Pro Ala 
                 165                170                175
Gly Leu Ile Thr Ala Asp Gly Gln Gln Gln Asn Val Met Val Tyr Thr 
             180                185                190
Thr Ser Tyr Gln Gln Ile Ser Gly Val Gln Gln Ile Gln Phe Ser 
         195                200                205



<210> 4763
<211> 456
<212> DNA
<213> Rattus norvegicus
<308> AA817854
<400> 4763

ttttttttt  tttttttcc  tatgcagag  acctttttt  cagagtatc  acggtccta  60
gagtcctga  gcaatatct  ttggagcat  cacatgaga  tggtaaatc  tggtcacac  120
attgctgtc  ccctcgcca  gacttggct  attggcacg  agcacgtac  aatactgct  180
tccaggaaa  agtttgtca  cggctcttt  aaaatcagt  gtgttgtca  ggtagatgg  240
cccctcgtt  gccttggtg  aagttaccc  atgagcatg  aaagtgtag  gcctagagg  300
aaagttctt  acgtgaaca  aaactttgt  tccaacttc  gctttgatg  cagggccta  360
aagccctat  caggctggt  tgtctatag  cttcgtaaa  gtgccatct  tgtactcag  420
ataaagggc  ttcttatac  ttcttcact  gtgccg  456



<210> 4764
<211> 1059
<212> PRT
<213> Rattus norvegicus
<308> P13635
<400> 4764

Met Lys Phe Leu Leu Leu Ser Ala Leu Leu Phe Leu His Ser Ser Leu 
  1               5                  10                  15
Ala Trp Thr Arg Glu Lys His Tyr Tyr Ile Gly Ile Thr Glu Ala Val 
             20                  25                  30
Trp Asp Tyr Ala Ser Gly Ser Glu Glu Lys Glu Leu Ile Ser Val Asp 
         35                  40                  45
Thr Glu Gln Ser Asn Phe Tyr Leu Arg Asn Gly Pro Asp Arg Ile Gly 
     50                  55                  60
Arg Lys Tyr Lys Lys Ala Leu Tyr Ser Glu Tyr Thr Asp Gly Thr Phe 
 65                  70                  75                  80
Thr Lys Thr Ile Asp Lys Pro Ala Trp Leu Gly Phe Leu Gly Pro Val 
                 85                  90                  95
Ile Lys Ala Glu Val Gly Asp Lys Val Ser Val His Val Lys Asn Phe 
             100                105                110
Ala Ser Arg Pro Tyr Thr Phe His Ala His Gly Val Thr Tyr Thr Lys 
         115                120                125
Ala Asn Glu Gly Ala Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln Arg 
     130                135                140
Ala Asp Asp Lys Leu Phe Pro Gly Gln Gln Tyr Leu Tyr Val Leu Arg 
 145                150                155                160
Ala Asn Glu Pro Ser Pro Gly Glu Gly Asp Ser Asn Cys Val Thr Arg 
                 165                170                175
Ile Tyr His Ser His Val Asp Ala Pro Lys Asp Ile Ala Ser Gly Leu 
             180                185                190
Ile Gly Pro Leu Ile Leu Cys Lys Lys Gly Ser Leu His Lys Glu Lys 
         195                200                205
Glu Glu Asn Ile Asp Gln Glu Phe Val Leu Met Phe Ser Val Val Asp 
     210                215                220
Glu Asn Leu Ser Trp Tyr Leu Glu Asp Asn Ile Lys Thr Phe Cys Ser 
 225                230                235                240
Glu Pro Glu Lys Val Asp Lys Asp Asn Glu Asp Phe Gln Glu Ser Asn 
                 245                250                255
Arg Met Tyr Ser Ile Asn Gly Tyr Thr Phe Gly Ser Leu Pro Gly Leu 
             260                265                270
Ser Met Cys Ala Glu Asp Arg Val Lys Trp Tyr Leu Phe Gly Met Gly 
         275                280                285
Asn Glu Val Asp Val His Ser Glu Leu Phe His Gly Gln Ala Leu Thr 
     290                295                300
Ser Lys Asn Tyr His Thr Asp Ile Ile Asn Leu Phe Pro Ala Thr Leu 
 305                310                315                320
Ile Asp Val Ser Met Val Ala Gln Asn Pro Gly Val Trp Met Leu Ser 
                 325                330                335
Cys Gln Asn Leu Asn His Leu Lys Ala Gly Leu Gln Ala Phe Phe Gln 
             340                345                350
Val Arg Asp Cys Asn Lys Pro Ser Pro Asp Asp Asp Ile Gln Asp Arg 
         355                360                365
His Val Arg His Tyr Tyr Ile Ala Ala Glu Glu Thr Ile Trp Asp Tyr 
     370                375                380
Ala Pro Ser Gly Thr Asp Thr Phe Thr Gly Glu Asn Phe Thr Ser Leu 
 385                390                395                400
Gly Ser Asp Ser Arg Val Phe Phe Glu Gln Gly Ala Thr Arg Ile Gly 
                 405                410                415
Gly Ser Tyr Lys Lys Leu Val Tyr Arg Glu Tyr Thr Asp Asp Ser Phe 
             420                425                430
Thr Asn Arg Lys Glu Arg Gly Pro Asp Glu Glu His Leu Gly Ile Leu 
         435                440                445
Gly Pro Val Ile Trp Ala Glu Val Gly Asp Ile Ile Arg Val Thr Phe 
     450                455                460
His Asn Lys Gly Gln Phe Pro Leu Ser Ile Gln Pro Met Gly Val Arg 
 465                470                475                480
Phe Thr Lys Glu Asn Glu Gly Thr Tyr Tyr Gly Pro Asp Gly Arg Ser 
                 485                490                495
Ser Lys Gln Ala Ser His Val Ala Pro Lys Glu Thr Phe Thr Tyr Glu 
             500                505                510
Trp Thr Val Pro Lys Glu Met Gly Pro Thr Tyr Ala Asp Pro Val Cys 
         515                520                525
Leu Ser Lys Met Tyr Tyr Ser Gly Val Asp Leu Thr Lys Asp Ile Phe 
     530                535                540
Thr Gly Leu Ile Gly Pro Met Lys Ile Cys Lys Lys Gly Ser Leu Leu 
 545                550                555                560
Ala Asp Gly Arg Gln Lys Asp Val Asp Lys Glu Phe Tyr Leu Phe Ala 
                 565                570                575
Thr Val Phe Asp Glu Asn Glu Ser Leu Leu Leu Asp Asp Asn Ile Arg 
             580                585                590
Met Phe Thr Thr Ala Pro Glu Asn Val Asp Lys Glu Asp Glu Asp Phe 
         595                600                605
Gln Glu Ser Asn Lys Met His Ser Met Asn Gly Phe Met Tyr Gly Asn 
     610                615                620
Leu Pro Gly Leu Asn Met Cys Leu Gly Glu Ser Ile Val Trp Tyr Leu 
 625                630                635                640
Phe Ser Ala Gly Asn Glu Ala Asp Val His Gly Ile Tyr Phe Ser Gly 
                 645                650                655
Asn Thr Tyr Leu Ser Lys Gly Glu Arg Arg Asp Thr Ala Asn Leu Phe 
             660                665                670
Pro His Lys Ser Leu Thr Leu Leu Met Thr Pro Asp Thr Glu Gly Ser 
         675                680                685
Phe Asp Val Glu Cys Leu Thr Thr Asp His Tyr Thr Gly Gly Met Lys 
     690                695                700
Gln Lys Tyr Thr Val Asn Gln Cys Lys Gly Gln Phe Glu Asp Val Thr 
 705                710                715                720
Leu Tyr Gln Gly Glu Arg Thr Tyr Tyr Ile Ala Ala Val Glu Val Glu 
                 725                730                735
Trp Asp Tyr Ser Pro Ser Arg Asp Trp Glu Met Glu Leu His His Leu 
             740                745                750
Gln Glu Gln Asn Val Ser Asn Ala Phe Leu Asp Lys Glu Glu Phe Phe 
         755                760                765
Ile Gly Ser Lys Tyr Lys Lys Val Val Tyr Arg Glu Phe Thr Asp Ser 
     770                775                780
Thr Phe Arg Glu Gln Val Lys Arg Arg Ala Glu Glu Glu His Leu Gly 
 785                790                795                800
Met Leu Gly Pro Leu Ile His Ala Asp Val Gly Ala Lys Val Lys Val 
                 805                810                815
Val Phe Lys Asn Met Ala Thr Arg Pro Tyr Ser Ile His Ala His Gly 
             820                825                830
Val Lys Thr Lys Ser Ser Thr Val Ala Pro Thr Leu Pro Gly Glu Val 
         835                840                845
Arg Thr Tyr Ile Trp Gln Ile Pro Glu Arg Ser Gly Ala Gly Thr Glu 
     850                855                860
Asp Ser Pro Cys Ile Pro Trp Ala Tyr Tyr Ser Thr Val Asp Arg Val 
 865                870                875                880
Lys Asp Leu Tyr Ser Gly Leu Ile Gly Pro Leu Ile Val Cys Arg Lys 
                 885                890                895
Ser Tyr Val Lys Val Phe Asn Pro Lys Lys Lys Met Glu Phe Ser Leu 
             900                905                910
Leu Phe Leu Val Phe Asp Glu Asn Glu Ser Trp Tyr Leu Asp Asp Asn 
         915                920                925
Ile Asn Thr Tyr Pro Asp His Pro Glu Lys Asp Asn Lys Asp Asn Glu 
     930                935                940
Glu Phe Ile Glu Ser Asn Lys Met His Ala Ile Asn Gly Lys Met Phe 
 945                950                955                960
Gly Asn Leu Gln Gly Leu Thr Met His Val Gly Asp Glu Val Asn Trp 
                 965                970                975
Tyr Val Met Ala Met Gly Asn Glu Ile Asp Leu His Thr Val His Phe 
             980                985                990
His Gly His Ser Phe Gln Tyr Lys His Arg Gly Ile His Ser Ser Asp 
         995                1000                1005
Val Phe Asp Phe Phe Pro Gly Thr Tyr Gln Thr Leu Glu Met Phe Pro 
     1010                1015                1020
Gln Thr Pro Gly Thr Trp Leu Leu His Cys His Val Thr Asp His Ile 
 1025                1030                1035                1040
His Ala Gly Met Val Thr Thr Tyr Thr Val Leu Pro Asn Gln Glu Thr 
                 1045                1050                1055
Lys Ser Gly 
             1060



<210> 4765
<211> 3321
<212> DNA
<213> Homo sapiens
<308> M13699
<400> 4765

atgaagatt  tgatacttg  tatttttct  tttttatgt  gtaccccag  ctgggcgaa  60
gaaaagcat  attacattg  aattattga  acgacttgg  attatgcct  tgaccatgg  120
gaaaagaaa  ttatttctg  tgacacgga  cattccaat  tctatcttc  aaatggccc  180
gatagaatt  ggagactat  taagaaggc  ctttatctt  agtacacag  tgaaacctt  240
aggacaact  tagaaaaac  ggtctggct  gggttttta  gccctatta  caaagctga  300
actggagat  aagtttatg  acacttaaa  aaccttgcc  ctaggccct  cacctttca  360
tcacatgga  taacttact  taaggaaca  gagggggcc  tctaccctg  taacaccac  420
gattttcaa  gagcagatg  caaagtata  ccaggagag  agtatacat  catgttgct  480
gccactgaa  aacaaagtc  tggggaagg  gatggcaat  gtgtgacta  gatttacca  540
tcccacatt  atgctccaa  agatattgc  tcaggactc  tcggacctt  aataatctg  600
aaaaaagat  ctctagata  agaaaaaga  aaacatatt  accgagaat  tgtggtgat  660
ttttctgtg  tggatgaaa  tttcagctg  tacctagaa  acaacatta  aacctactg  720
tcagaacca  agaaagttg  caaagacaa  gaagacttc  aggagagta  cagaatgta  780
tctgtgaat  gatacactt  tggaagtct  ccaggactc  ccatgtgtg  tgaagacag  840
gtaaaatgg  acctttttg  tatgggtaa  gaagttgat  tgcacgcag  tttctttca  900
gggcaagca  tgactaaca  gaactaccg  attgacaca  tcaacctct  tcctgctac  960
ctgtttgat  cttatatgg  ggcccagaa  cctggagaa  ggatgctca  ctgtcagaa  1020
ctaaaccat  tgaaagccg  tttgcaagc  tttttccag  tccaggagt  taacaagtc  1080
tcatcaaag  ataatatcc  tgggaagca  gttagacac  actacattg  cgctgagga  1140
atcatctgg  actatgctc  ctctggtat  gacatcttc  ctaaagaaa  cttaacagc  1200
cctggaagt  actcagcgg  gttttttga  caaggtacc  caagaattg  aggctctta  1260
aaaaagctg  tttatcgtg  gtacacaga  gcctccttc  caaatcgaa  ggagagagg  1320
cctgaagaa  agcatcttg  catcctggg  cctgtcatt  gggcagagg  gggagacac  1380
atcagagta  ccttccata  caaaggagc  tatcccctc  gtattgagc  gattggggt  1440
agattcaat  agaacaacg  gggcacata  tattcccca  attacaacc  ccagagcag  1500
agtgtgcct  cttcagcct  ccatgtggc  cccacagaa  cattcacct  tgaatggac  1560
gtccccaaa  aagtaggac  cactaatgc  gatcctgtg  gtctagcta  gatgtatta  1620
tctgctgtg  atcccacta  agatatatt  actgggctt  ttgggccaa  gaaaatatg  1680
aagaaagga  gtttacatg  aaatgggag  cagaaagat  tagacaagg  attctattt  1740
tttcctaca  tatttgatg  gaatgagag  ttactcctg  aagataata  tagaatgtt  1800
acaactgca  ctgatcagg  ggataagga  gatgaagac  ttcaggaat  taataaaat  1860
cactccatg  atggattca  gtatgggaa  cagccgggt  tcactatgt  caaaggaga  1920
tcggtcgtg  ggtacttat  cagcgccgg  aatgaggcc  atgtacatg  aatatactt  1980
tcaggaaac  catatctgt  gagaggaga  cggagagac  cagcaaacc  cttccctca  2040
acaagtctt  cgctccaca  gtggcctga  acagagggg  cttttaatg  tgaatgcct  2100
acaactgat  attacacag  cggcatgaa  caaaaatat  ctgtgaacc  atgcaggcg  2160
cagtctgag  attccacct  ctacctggg  gagaggaca  actatatcg  agcagtgga  2220
gtggaatgg  attattccc  acaaaggga  tgggaaaag  agctgcatc  tttacaaga  2280
cagaatgtt  caaatgcat  tttagataa  ggagagttt  acataggct  aaagtacaa  2340
aaagttgtg  atcggcagt  tactgatag  acattccgt  ttccagtgg  gagaaaagc  2400
gaagaagaa  atctgggaa  tctaggtcc  caacttcat  cagatgttg  agacaaagt  2460
aaaattatc  ttaaaaaca  ggccacaag  ccctactca  tacatgccc  tggggtaca  2520
acagagagt  ctacagtta  tccaacatt  ccaggtgaa  ctctcactt  cgtatggaa  2580
atcccagaa  gatctggag  tggaacaga  gattctgct  gtattccat  ggcttatta  2640
tcaactgtg  atcaagtta  ggacctcta  agtggatta  ttggccccc  gattgtttg  2700
cgaagacct  acttgaaag  attcaatcc  agaaggaag  tggaatttg  ccttctgtt  2760
ctagttttt  atgagaatg  atcttggta  ttagatgac  acatcaaaa  atactctga  2820
caccccgag  aagtaaaca  agatgatga  gaattcata  aaagcaata  aatgcatgc  2880
attaatgga  gaatgtttg  aaacctaca  ggcctcaca  tgcacgtgg  agatgaagt  2940
aactggtat  tgatgggaa  gggcaatga  atagactta  acactgtac  ttttcacgg  3000
catagcttc  aatacaagc  caggggagt  tatagttct  atgtctttg  cattttccc  3060
ggaacatac  aaaccctag  aatgtttcc  agaacacct  gaatttggt  actccactg  3120
catgtgacc  accacattc  tgctggaat  gaaaccact  acaccgttc  acaaaatga  3180
gacaccaaa  ctggctgaa  gaaataaat  ggtgataag  ggaaaaaag  gaaaaacca  3240
tgattcata  caatgtatg  gaaagtgta  aatagaatg  tactttgga  tgactataa  3300
cattaaaag  gactggagc  t  3321



<210> 4766
<211> 1065
<212> PRT
<213> Homo sapiens
<308> P00450
<400> 4766

Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
  1               5                  10                  15
Ala Trp Ala Lys Glu Lys His Tyr Tyr Ile Gly Ile Ile Glu Thr Thr 
             20                  25                  30
Trp Asp Tyr Ala Ser Asp His Gly Glu Lys Lys Leu Ile Ser Val Asp 
         35                  40                  45
Thr Glu His Ser Asn Ile Tyr Leu Gln Asn Gly Pro Asp Arg Ile Gly 
     50                  55                  60
Arg Leu Tyr Lys Lys Ala Leu Tyr Leu Gln Tyr Thr Asp Glu Thr Phe 
 65                  70                  75                  80
Arg Thr Thr Ile Glu Lys Pro Val Trp Leu Gly Phe Leu Gly Pro Ile 
                 85                  90                  95
Ile Lys Ala Glu Thr Gly Asp Lys Val Tyr Val His Leu Lys Asn Leu 
             100                105                110
Ala Ser Arg Pro Tyr Thr Phe His Ser His Gly Ile Thr Tyr Tyr Lys 
         115                120                125
Glu His Glu Gly Ala Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln Arg 
     130                135                140
Ala Asp Asp Lys Val Tyr Pro Gly Glu Gln Tyr Thr Tyr Met Leu Leu 
 145                150                155                160
Ala Thr Glu Glu Gln Ser Pro Gly Glu Gly Asp Gly Asn Cys Val Thr 
                 165                170                175
Arg Ile Tyr His Ser His Ile Asp Ala Pro Lys Asp Ile Ala Ser Gly 
             180                185                190
Leu Ile Gly Pro Leu Ile Ile Cys Lys Lys Asp Ser Leu Asp Lys Glu 
         195                200                205
Lys Glu Lys His Ile Asp Arg Glu Phe Val Val Met Phe Ser Val Val 
     210                215                220
Asp Glu Asn Phe Ser Trp Tyr Leu Glu Asp Asn Ile Lys Thr Tyr Cys 
 225                230                235                240
Ser Glu Pro Glu Lys Val Asp Lys Asp Asn Glu Asp Phe Gln Glu Ser 
                 245                250                255
Asn Arg Met Tyr Ser Val Asn Gly Tyr Thr Phe Gly Ser Leu Pro Gly 
             260                265                270
Leu Ser Met Cys Ala Glu Asp Arg Val Lys Trp Tyr Leu Phe Gly Met 
         275                280                285
Gly Asn Glu Val Asp Val His Ala Ala Phe Phe His Gly Gln Ala Leu 
     290                295                300
Thr Asn Lys Asn Tyr Arg Ile Asp Thr Ile Asn Leu Phe Pro Ala Thr 
 305                310                315                320
Leu Phe Asp Ala Tyr Met Val Ala Gln Asn Pro Gly Glu Trp Met Leu 
                 325                330                335
Ser Cys Gln Asn Leu Asn His Leu Lys Ala Gly Leu Gln Ala Phe Phe 
             340                345                350
Gln Val Gln Glu Cys Asn Lys Ser Ser Ser Lys Asp Asn Ile Arg Gly 
         355                360                365
Lys His Val Arg His Tyr Tyr Ile Ala Ala Glu Glu Ile Ile Trp Asn 
     370                375                380
Tyr Ala Pro Ser Gly Ile Asp Ile Phe Thr Lys Glu Asn Leu Thr Ala 
 385                390                395                400
Pro Gly Ser Asp Ser Ala Val Phe Phe Glu Gln Gly Thr Thr Arg Ile 
                 405                410                415
Gly Gly Ser Tyr Lys Lys Leu Val Tyr Arg Glu Tyr Thr Asp Ala Ser 
             420                425                430
Phe Thr Asn Arg Lys Glu Arg Gly Pro Glu Glu Glu His Leu Gly Ile 
         435                440                445
Leu Gly Pro Val Ile Trp Ala Glu Val Gly Asp Thr Ile Arg Val Thr 
     450                455                460
Phe His Asn Lys Gly Ala Tyr Pro Leu Ser Ile Glu Pro Ile Gly Val 
 465                470                475                480
Arg Phe Asn Lys Asn Asn Glu Gly Thr Tyr Tyr Ser Pro Asn Tyr Asn 
                 485                490                495
Pro Gln Ser Arg Ser Val Pro Pro Ser Ala Ser His Val Ala Pro Thr 
             500                505                510
Glu Thr Phe Thr Tyr Glu Trp Thr Val Pro Lys Glu Val Gly Pro Thr 
         515                520                525
Asn Ala Asp Pro Val Cys Leu Ala Lys Met Tyr Tyr Ser Ala Val Asp 
     530                535                540
Pro Thr Lys Asp Ile Phe Thr Gly Leu Ile Gly Pro Met Lys Ile Cys 
 545                550                555                560
Lys Lys Gly Ser Leu His Ala Asn Gly Arg Gln Lys Asp Val Asp Lys 
                 565                570                575
Glu Phe Tyr Leu Phe Pro Thr Val Phe Asp Glu Asn Glu Ser Leu Leu 
             580                585                590
Leu Glu Asp Asn Ile Arg Met Phe Thr Thr Ala Pro Asp Gln Val Asp 
         595                600                605
Lys Glu Asp Glu Asp Phe Gln Glu Ser Asn Lys Met His Ser Met Asn 
     610                615                620
Gly Phe Met Tyr Gly Asn Gln Pro Gly Leu Thr Met Cys Lys Gly Asp 
 625                630                635                640
Ser Val Val Trp Tyr Leu Phe Ser Ala Gly Asn Glu Ala Asp Val His 
                 645                650                655
Gly Ile Tyr Phe Ser Gly Asn Thr Tyr Leu Trp Arg Gly Glu Arg Arg 
             660                665                670
Asp Thr Ala Asn Leu Phe Pro Gln Thr Ser Leu Thr Leu His Met Trp 
         675                680                685
Pro Asp Thr Glu Gly Thr Phe Asn Val Glu Cys Leu Thr Thr Asp His 
     690                695                700
Tyr Thr Gly Gly Met Lys Gln Lys Tyr Thr Val Asn Gln Cys Arg Arg 
 705                710                715                720
Gln Ser Glu Asp Ser Thr Phe Tyr Leu Gly Glu Arg Thr Tyr Tyr Ile 
                 725                730                735
Ala Ala Val Glu Val Glu Trp Asp Tyr Ser Pro Gln Arg Glu Trp Glu 
             740                745                750
Lys Glu Leu His His Leu Gln Glu Gln Asn Val Ser Asn Ala Phe Leu 
         755                760                765
Asp Lys Gly Glu Phe Tyr Ile Gly Ser Lys Tyr Lys Lys Val Val Tyr 
     770                775                780
Arg Gln Tyr Thr Asp Ser Thr Phe Arg Val Pro Val Glu Arg Lys Ala 
 785                790                795                800
Glu Glu Glu His Leu Gly Ile Leu Gly Pro Gln Leu His Ala Asp Val 
                 805                810                815
Gly Asp Lys Val Lys Ile Ile Phe Lys Asn Met Ala Thr Arg Pro Tyr 
             820                825                830
Ser Ile His Ala His Gly Val Gln Thr Glu Ser Ser Thr Val Thr Pro 
         835                840                845
Thr Leu Pro Gly Glu Thr Leu Thr Tyr Val Trp Lys Ile Pro Glu Arg 
     850                855                860
Ser Gly Ala Gly Thr Glu Asp Ser Ala Cys Ile Pro Trp Ala Tyr Tyr 
 865                870                875                880
Ser Thr Val Asp Gln Val Lys Asp Leu Tyr Ser Gly Leu Ile Gly Pro 
                 885                890                895
Leu Ile Val Cys Arg Arg Pro Tyr Leu Lys Val Phe Asn Pro Arg Arg 
             900                905                910
Lys Leu Glu Phe Ala Leu Leu Phe Leu Val Phe Asp Glu Asn Glu Ser 
         915                920                925
Trp Tyr Leu Asp Asp Asn Ile Lys Thr Tyr Ser Asp His Pro Glu Lys 
     930                935                940
Val Asn Lys Asp Asp Glu Glu Phe Ile Glu Ser Asn Lys Met His Ala 
 945                950                955                960
Ile Asn Gly Arg Met Phe Gly Asn Leu Gln Gly Leu Thr Met His Val 
                 965                970                975
Gly Asp Glu Val Asn Trp Tyr Leu Met Gly Met Gly Asn Glu Ile Asp 
             980                985                990
Leu His Thr Val His Phe His Gly His Ser Phe Gln Tyr Lys His Arg 
         995                1000                1005
Gly Val Tyr Ser Ser Asp Val Phe Asp Ile Phe Pro Gly Thr Tyr Gln 
     1010                1015                1020
Thr Leu Glu Met Phe Pro Arg Thr Pro Gly Ile Trp Leu Leu His Cys 
 1025                1030                1035                1040
His Val Thr Asp His Ile His Ala Gly Met Glu Thr Thr Tyr Thr Val 
                 1045                1050                1055
Leu Gln Asn Glu Asp Thr Lys Ser Gly 
             1060                1065



<210> 4767
<211> 581
<212> DNA
<213> Rattus norvegicus
<308> AA817997
<400> 4767

ttttttttt  tttttttca  ctagagaca  atctttatt  ttaaactct  atctactaa  60
ttagcgttt  ccaccaact  tgggagcag  gaccttcac  ggcttcaca  tcttttgtt  120
aggggctgc  tttgtggga  ccttggcag  agccattgc  gtcttcttt  atgcctgct  180
agccttttt  gcttccttg  cagccctga  agcctgttc  cgctgagct  tcctaactt  240
tggtttctg  ttcctcttg  ccattatat  agccagaga  gcgcctgtg  tggcccgct  300
gaacttgac  gcacggcgg  ttcttttct  ttgaatttc  tccgactgt  ctttcttgt  360
ttttcttct  tagaggaca  tccagttaa  ttgccgagg  ttccttttg  aaaggaatg  420
ggactcaca  ttggcatta  gaaactgga  aaccttccc  tcggtcctg  cgtancgcc  480
cccgtgtcn  gggtagatc  tgtacccac  anaactgca  agctcgacc  tcatggtga  540
agatgtcgg  ctgccgggg  aaagcctcg  gccgaattc  t  581



<210> 4768
<211> 157
<212> PRT
<213> Rattus norvegicus
<308> P38663
<400> 4768

Met Lys Val Glu Leu Cys Ser Phe Ser Gly Tyr Lys Ile Tyr Pro Gly 
  1               5                  10                  15
His Gly Arg Arg Tyr Ala Arg Thr Asp Gly Lys Val Phe Gln Phe Leu 
             20                  25                  30
Asn Ala Lys Cys Glu Ser Ala Phe Leu Ser Lys Arg Asn Pro Arg Gln 
         35                  40                  45
Ile Asn Trp Thr Val Leu Tyr Arg Arg Lys His Lys Lys Gly Gln Ser 
     50                  55                  60
Glu Glu Ile Gln Lys Lys Arg Thr Arg Arg Ala Val Lys Phe Gln Arg 
 65                  70                  75                  80
Ala Ile Thr Gly Ala Ser Leu Ala Asp Ile Met Ala Lys Arg Asn Gln 
                 85                  90                  95
Lys Pro Glu Val Arg Lys Ala Gln Arg Glu Gln Ala Ile Arg Ala Ala 
             100                105                110
Lys Glu Ala Lys Lys Ala Lys Gln Ala Ser Lys Lys Thr Ala Met Ala 
         115                120                125
Ala Ala Lys Ala Pro Thr Lys Ala Ala Pro Lys Gln Lys Ile Val Lys 
     130                135                140
Pro Val Lys Val Ser Ala Pro Arg Val Gly Gly Lys Arg 
 145                150                155



<210> 4769
<211> 341
<212> DNA
<213> Homo sapiens
<308> AA380579
<400> 4769

gtcgccatg  aggtcgagc  gtgcagttt  agcgggtac  agatctacc  cggacacgg  60
aggcgctac  ccaggaccg  cgggaaggt  ttccagttt  ttaatgcga  atgcgagtc  120
gctttcctt  ccaagagga  tcctcggca  ataaactgg  ctgtcctct  cagaaggaa  180
cacaaaaag  gacagtcgg  agaaattca  aagaaaaga  cccgccgag  agtcaaatt  240
cagagggcc  ttactggtg  atctnttgc  gatataatg  ccaagagga  ttcagaaac  300
tgaagttag  aaggcttca  cggggaaca  gctattcag  g  341



<210> 4770
<211> 157
<212> PRT
<213> Homo sapiens
<308> P38663
<400> 4770

Met Lys Val Glu Leu Cys Ser Phe Ser Gly Tyr Lys Ile Tyr Pro Gly 
  1               5                  10                  15
His Gly Arg Arg Tyr Ala Arg Thr Asp Gly Lys Val Phe Gln Phe Leu 
             20                  25                  30
Asn Ala Lys Cys Glu Ser Ala Phe Leu Ser Lys Arg Asn Pro Arg Gln 
         35                  40                  45
Ile Asn Trp Thr Val Leu Tyr Arg Arg Lys His Lys Lys Gly Gln Ser 
     50                  55                  60
Glu Glu Ile Gln Lys Lys Arg Thr Arg Arg Ala Val Lys Phe Gln Arg 
 65                  70                  75                  80
Ala Ile Thr Gly Ala Ser Leu Ala Asp Ile Met Ala Lys Arg Asn Gln 
                 85                  90                  95
Lys Pro Glu Val Arg Lys Ala Gln Arg Glu Gln Ala Ile Arg Ala Ala 
             100                105                110
Lys Glu Ala Lys Lys Ala Lys Gln Ala Ser Lys Lys Thr Ala Met Ala 
         115                120                125
Ala Ala Lys Ala Pro Thr Lys Ala Ala Pro Lys Gln Lys Ile Val Lys 
     130                135                140
Pro Val Lys Val Ser Ala Pro Arg Val Gly Gly Lys Arg 
 145                150                155



<210> 4771
<211> 581
<212> DNA
<213> Rattus norvegicus
<308> AA817997
<400> 4771

ttttttttt  tttttttca  ctagagaca  atctttatt  ttaaactct  atctactaa  60
ttagcgttt  ccaccaact  tgggagcag  gaccttcac  ggcttcaca  tcttttgtt  120
aggggctgc  tttgtggga  ccttggcag  agccattgc  gtcttcttt  atgcctgct  180
agccttttt  gcttccttg  cagccctga  agcctgttc  cgctgagct  tcctaactt  240
tggtttctg  ttcctcttg  ccattatat  agccagaga  gcgcctgtg  tggcccgct  300
gaacttgac  gcacggcgg  ttcttttct  ttgaatttc  tccgactgt  ctttcttgt  360
ttttcttct  tagaggaca  tccagttaa  ttgccgagg  ttccttttg  aaaggaatg  420
ggactcaca  ttggcatta  gaaactgga  aaccttccc  tcggtcctg  cgtancgcc  480
cccgtgtcn  gggtagatc  tgtacccac  anaactgca  agctcgacc  tcatggtga  540
agatgtcgg  ctgccgggg  aaagcctcg  gccgaattc  t  581



<210> 4772
<211> 157
<212> PRT
<213> Rattus norvegicus
<308> P38663
<400> 4772

Met Lys Val Glu Leu Cys Ser Phe Ser Gly Tyr Lys Ile Tyr Pro Gly 
  1               5                  10                  15
His Gly Arg Arg Tyr Ala Arg Thr Asp Gly Lys Val Phe Gln Phe Leu 
             20                  25                  30
Asn Ala Lys Cys Glu Ser Ala Phe Leu Ser Lys Arg Asn Pro Arg Gln 
         35                  40                  45
Ile Asn Trp Thr Val Leu Tyr Arg Arg Lys His Lys Lys Gly Gln Ser 
     50                  55                  60
Glu Glu Ile Gln Lys Lys Arg Thr Arg Arg Ala Val Lys Phe Gln Arg 
 65                  70                  75                  80
Ala Ile Thr Gly Ala Ser Leu Ala Asp Ile Met Ala Lys Arg Asn Gln 
                 85                  90                  95
Lys Pro Glu Val Arg Lys Ala Gln Arg Glu Gln Ala Ile Arg Ala Ala 
             100                105                110
Lys Glu Ala Lys Lys Ala Lys Gln Ala Ser Lys Lys Thr Ala Met Ala 
         115                120                125
Ala Ala Lys Ala Pro Thr Lys Ala Ala Pro Lys Gln Lys Ile Val Lys 
     130                135                140
Pro Val Lys Val Ser Ala Pro Arg Val Gly Gly Lys Arg 
 145                150                155



<210> 4773
<211> 341
<212> DNA
<213> Homo sapiens
<308> AA380579
<400> 4773

gtcgccatg  aggtcgagc  gtgcagttt  agcgggtac  agatctacc  cggacacgg  60
aggcgctac  ccaggaccg  cgggaaggt  ttccagttt  ttaatgcga  atgcgagtc  120
gctttcctt  ccaagagga  tcctcggca  ataaactgg  ctgtcctct  cagaaggaa  180
cacaaaaag  gacagtcgg  agaaattca  aagaaaaga  cccgccgag  agtcaaatt  240
cagagggcc  ttactggtg  atctnttgc  gatataatg  ccaagagga  ttcagaaac  300
tgaagttag  aaggcttca  cggggaaca  gctattcag  g  341



<210> 4774
<211> 157
<212> PRT
<213> Homo sapiens
<308> P38663
<400> 4774

Met Lys Val Glu Leu Cys Ser Phe Ser Gly Tyr Lys Ile Tyr Pro Gly 
  1               5                  10                  15
His Gly Arg Arg Tyr Ala Arg Thr Asp Gly Lys Val Phe Gln Phe Leu 
             20                  25                  30
Asn Ala Lys Cys Glu Ser Ala Phe Leu Ser Lys Arg Asn Pro Arg Gln 
         35                  40                  45
Ile Asn Trp Thr Val Leu Tyr Arg Arg Lys His Lys Lys Gly Gln Ser 
     50                  55                  60
Glu Glu Ile Gln Lys Lys Arg Thr Arg Arg Ala Val Lys Phe Gln Arg 
 65                  70                  75                  80
Ala Ile Thr Gly Ala Ser Leu Ala Asp Ile Met Ala Lys Arg Asn Gln 
                 85                  90                  95
Lys Pro Glu Val Arg Lys Ala Gln Arg Glu Gln Ala Ile Arg Ala Ala 
             100                105                110
Lys Glu Ala Lys Lys Ala Lys Gln Ala Ser Lys Lys Thr Ala Met Ala 
         115                120                125
Ala Ala Lys Ala Pro Thr Lys Ala Ala Pro Lys Gln Lys Ile Val Lys 
     130                135                140
Pro Val Lys Val Ser Ala Pro Arg Val Gly Gly Lys Arg 
 145                150                155



<210> 4775
<211> 504
<212> DNA
<213> Rattus norvegicus
<308> AA818025
<400> 4775

ttttttttt  tttttttcc  atagcatag  gtttattat  ccattatgt  gaagacagt  60
aagataaac  gctttttca  gatcgaaaa  atgttggcc  ttacagttt  ctagtaaaa  120
ctagcaaag  ccaggcaat  ttcagagat  tgggataat  caggttgga  ccgcccgtc  180
acacttcta  aagaacaga  gttttgtgt  tttcctttc  tttttgttt  gttgttatt  240
ttgttttga  gtttttctt  tctatgtat  tatgtatgt  tgtatgtat  tatgtatgt  300
tgtatgtat  gacaggctt  ctctgtata  ccttggctg  ccgggaact  gctggcttt  360
acctcacgg  gatgcacct  cttctactc  caagtgctg  tattaaagg  atgcaccac  420
actcgccat  ttgtttttc  tttgaggca  ggtcttact  tatagtttt  ggtgacttg  480
agaccactg  gaaggtcag  ctgg  504



<210> 4776
<211> 126
<212> PRT
<213> Rattus norvegicus
<308> P27274
<400> 4776

Met Arg Ala Arg Arg Gly Phe Ile Leu Leu Leu Leu Leu Ala Val Leu 
  1               5                  10                  15
Cys Ser Thr Gly Val Ser Leu Arg Cys Tyr Asn Cys Leu Asp Pro Val 
             20                  25                  30
Ser Ser Cys Lys Thr Asn Ser Thr Cys Ser Pro Asn Leu Asp Ala Cys 
         35                  40                  45
Leu Val Ala Val Ser Gly Lys Gln Val Tyr Gln Gln Cys Trp Arg Phe 
     50                  55                  60
Ser Asp Cys Asn Ala Lys Phe Ile Leu Ser Arg Leu Glu Ile Ala Asn 
 65                  70                  75                  80
Val Gln Tyr Arg Cys Cys Gln Ala Asp Leu Cys Asn Lys Ser Phe Glu 
                 85                  90                  95
Asp Lys Pro Asn Asn Gly Ala Ile Ser Leu Leu Gly Lys Thr Ala Leu 
             100                105                110
Leu Val Thr Ser Val Leu Ala Ala Ile Leu Lys Pro Cys Phe 
         115                120                125



<210> 4777
<211> 1742
<212> DNA
<213> Homo sapiens
<308> AF052941
<400> 4777

gaccgcggc  gctcagcct  ccgccgatt  tatgttcca  gcctcaatg  ggagtccaa  60
catggagcc  ttcaagcag  agaaggtgg  ggactttta  gacatcgga  aggagctgg  120
gagtggcca  tttgccatc  tgaagaagt  ccgggagaa  agcacgggg  ttgagtatg  180
agccaagtt  atcaagaag  ggcagagcc  ggcgagccg  cgcggtgtg  gccgggagg  240
gatcgagcg  gaggtgagc  tcctgcggc  ggtgctgca  cacaatgtc  tcacgctgc  300
cgacgtcta  gagaaccgc  ccgacgtgg  gctcatcct  gagctagtg  ctggaggag  360
gctcttcga  ttcctggcc  agaaggagt  actgagtga  gaggaggcc  ccagcttca  420
taagcagat  ctggatggg  tgaactacc  tcacacaaa  aaaattgct  actttgatc  480
caagccaga  aacattatg  tgttagaca  gaatattcc  attccacac  tcaagctga  540
tgactttgg  ctggctcac  aaatagaag  tggagttga  tttaagaat  tttttggga  600
gccggaatt  gttgctcca  aaattgtga  ctacgagcc  ctgggtctg  aggctgaca  660
gtggagcat  ggcgtcatc  cctacatcc  cttaagtgg  gcatcccct  tcctgggag  720
cacgaagca  gaaacactg  caaatatca  atcagtgag  tacgacttt  atgaggaat  780
cttcagcca  acgagcgag  tggccaagg  ctttattcg  aagcttctg  ttaaagaga  840
ccggaaacg  ctcacaatc  aagaggctc  cagacaccc  tggatcacg  cggtggaca  900
ccagcaagc  atggtgcgc  gggagtctg  ggtcaatct  gagaacttc  ggaagcagt  960
tgtccgcag  cggtggaag  tttccttca  catcgtgtc  ctgtgcaac  acctcaccc  1020
ctcgctgat  aagaaggtg  acctgaggc  ggatgagga  ctgaggaac  gtgagagtg  1080
cactgagga  gacatcgcc  ggaggaaag  cctccaccc  cggaggagg  gcagcacct  1140
ctaactggc  tgacctgca  tggccgcca  ggaggtttg  gcccagcgg  gctcccttc  1200
gtgcagact  ttggaccca  ctcagcacc  gcacccggg  gtcctgagc  ctttgcaag  1260
gagatgggc  caaggaatt  agaagagct  gcaggcaag  caggagacc  tgggagctg  1320
ggctgtctt  tgtggagga  gctccagca  tcccaaagc  cttaattct  cataaaatg  1380
gctttcctc  gtctgccat  ctcagagtc  ggggtggga  tgtggactt  ggaaaacaa  1440
ataaaggac  tcctcatca  cacggggtg  aggtcagag  aaggcagcc  tcttcacag  1500
ctgaggggg  tcagaacca  cctggccaa  aattacacc  gagagacag  gtcctcccc  1560
ttgggaaca  ggtgattga  gaaagtgaa  cttgggtgt  agggaccaa  cctgtgacc  1620
cccagaacc  tggaagcca  gacgtcagg  tgaccaaca  ctcagacct  ctgaagcag  1680
ccattgctg  cccgccatg  tgtaatttt  ctcattttt  ttaaacttc  ggtttacct  1740
aa  1742



<210> 4778
<211> 128
<212> PRT
<213> Homo sapiens
<308> NP_000602
<400> 4778

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
  1               5                  10                  15
Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
             20                  25                  30
Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
         35                  40                  45
Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
     50                  55                  60
Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
 65                  70                  75                  80
Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                 85                  90                  95
Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
             100                105                110
Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
         115                120                125



<210> 4779
<211> 504
<212> DNA
<213> Rattus norvegicus
<308> AA818025
<400> 4779

ttttttttt  tttttttcc  atagcatag  gtttattat  ccattatgt  gaagacagt  60
aagataaac  gctttttca  gatcgaaaa  atgttggcc  ttacagttt  ctagtaaaa  120
ctagcaaag  ccaggcaat  ttcagagat  tgggataat  caggttgga  ccgcccgtc  180
acacttcta  aagaacaga  gttttgtgt  tttcctttc  tttttgttt  gttgttatt  240
ttgttttga  gtttttctt  tctatgtat  tatgtatgt  tgtatgtat  tatgtatgt  300
tgtatgtat  gacaggctt  ctctgtata  ccttggctg  ccgggaact  gctggcttt  360
acctcacgg  gatgcacct  cttctactc  caagtgctg  tattaaagg  atgcaccac  420
actcgccat  ttgtttttc  tttgaggca  ggtcttact  tatagtttt  ggtgacttg  480
agaccactg  gaaggtcag  ctgg  504



<210> 4780
<211> 126
<212> PRT
<213> Rattus norvegicus
<308> P27274
<400> 4780

Met Arg Ala Arg Arg Gly Phe Ile Leu Leu Leu Leu Leu Ala Val Leu 
  1               5                  10                  15
Cys Ser Thr Gly Val Ser Leu Arg Cys Tyr Asn Cys Leu Asp Pro Val 
             20                  25                  30
Ser Ser Cys Lys Thr Asn Ser Thr Cys Ser Pro Asn Leu Asp Ala Cys 
         35                  40                  45
Leu Val Ala Val Ser Gly Lys Gln Val Tyr Gln Gln Cys Trp Arg Phe 
     50                  55                  60
Ser Asp Cys Asn Ala Lys Phe Ile Leu Ser Arg Leu Glu Ile Ala Asn 
 65                  70                  75                  80
Val Gln Tyr Arg Cys Cys Gln Ala Asp Leu Cys Asn Lys Ser Phe Glu 
                 85                  90                  95
Asp Lys Pro Asn Asn Gly Ala Ile Ser Leu Leu Gly Lys Thr Ala Leu 
             100                105                110
Leu Val Thr Ser Val Leu Ala Ala Ile Leu Lys Pro Cys Phe 
         115                120                125



<210> 4781
<211> 1742
<212> DNA
<213> Homo sapiens
<308> AF052941
<400> 4781

gaccgcggc  gctcagcct  ccgccgatt  tatgttcca  gcctcaatg  ggagtccaa  60
catggagcc  ttcaagcag  agaaggtgg  ggactttta  gacatcgga  aggagctgg  120
gagtggcca  tttgccatc  tgaagaagt  ccgggagaa  agcacgggg  ttgagtatg  180
agccaagtt  atcaagaag  ggcagagcc  ggcgagccg  cgcggtgtg  gccgggagg  240
gatcgagcg  gaggtgagc  tcctgcggc  ggtgctgca  cacaatgtc  tcacgctgc  300
cgacgtcta  gagaaccgc  ccgacgtgg  gctcatcct  gagctagtg  ctggaggag  360
gctcttcga  ttcctggcc  agaaggagt  actgagtga  gaggaggcc  ccagcttca  420
taagcagat  ctggatggg  tgaactacc  tcacacaaa  aaaattgct  actttgatc  480
caagccaga  aacattatg  tgttagaca  gaatattcc  attccacac  tcaagctga  540
tgactttgg  ctggctcac  aaatagaag  tggagttga  tttaagaat  tttttggga  600
gccggaatt  gttgctcca  aaattgtga  ctacgagcc  ctgggtctg  aggctgaca  660
gtggagcat  ggcgtcatc  cctacatcc  cttaagtgg  gcatcccct  tcctgggag  720
cacgaagca  gaaacactg  caaatatca  atcagtgag  tacgacttt  atgaggaat  780
cttcagcca  acgagcgag  tggccaagg  ctttattcg  aagcttctg  ttaaagaga  840
ccggaaacg  ctcacaatc  aagaggctc  cagacaccc  tggatcacg  cggtggaca  900
ccagcaagc  atggtgcgc  gggagtctg  ggtcaatct  gagaacttc  ggaagcagt  960
tgtccgcag  cggtggaag  tttccttca  catcgtgtc  ctgtgcaac  acctcaccc  1020
ctcgctgat  aagaaggtg  acctgaggc  ggatgagga  ctgaggaac  gtgagagtg  1080
cactgagga  gacatcgcc  ggaggaaag  cctccaccc  cggaggagg  gcagcacct  1140
ctaactggc  tgacctgca  tggccgcca  ggaggtttg  gcccagcgg  gctcccttc  1200
gtgcagact  ttggaccca  ctcagcacc  gcacccggg  gtcctgagc  ctttgcaag  1260
gagatgggc  caaggaatt  agaagagct  gcaggcaag  caggagacc  tgggagctg  1320
ggctgtctt  tgtggagga  gctccagca  tcccaaagc  cttaattct  cataaaatg  1380
gctttcctc  gtctgccat  ctcagagtc  ggggtggga  tgtggactt  ggaaaacaa  1440
ataaaggac  tcctcatca  cacggggtg  aggtcagag  aaggcagcc  tcttcacag  1500
ctgaggggg  tcagaacca  cctggccaa  aattacacc  gagagacag  gtcctcccc  1560
ttgggaaca  ggtgattga  gaaagtgaa  cttgggtgt  agggaccaa  cctgtgacc  1620
cccagaacc  tggaagcca  gacgtcagg  tgaccaaca  ctcagacct  ctgaagcag  1680
ccattgctg  cccgccatg  tgtaatttt  ctcattttt  ttaaacttc  ggtttacct  1740
aa  1742



<210> 4782
<211> 128
<212> PRT
<213> Homo sapiens
<308> NP_000602
<400> 4782

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
  1               5                  10                  15
Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
             20                  25                  30
Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
         35                  40                  45
Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
     50                  55                  60
Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
 65                  70                  75                  80
Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                 85                  90                  95
Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
             100                105                110
Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
         115                120                125



<210> 4783
<211> 158
<212> DNA
<213> Rattus norvegicus
<308> AA818152
<400> 4783

cggccgcat  cattttgtt  ttcatgtgt  ttttttttt  taacacttc  caattagtt  60
ttattcata  tcataaact  aaccttgca  tcctgctag  cttgaaggg  aatgaagaa  120
atatggaac  caaagaact  caatgcaaa  acatatta  158



<210> 4784
<211> 163
<212> PRT
<213> Rattus norvegicus
<308> P10111
<400> 4784

Val Asn Pro Thr Val Phe Phe Asp Ile Thr Ala Asp Gly Glu Pro Leu 
  1               5                  10                  15
Gly Arg Val Cys Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala 
             20                  25                  30
Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys 
         35                  40                  45
Gly Ser Ser Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly 
     50                  55                  60
Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu 
 65                  70                  75                  80
Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile 
                 85                  90                  95
Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe 
             100                105                110
Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val Phe 
         115                120                125
Gly Lys Val Lys Glu Gly Met Ser Ile Val Glu Ala Met Glu Arg Phe 
     130                135                140
Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ser Asp Cys 
 145                150                155                160
Gly Gln Leu 
                 165



<210> 4785
<211> 382
<212> DNA
<213> Homo sapiens
<308> AA071425
<400> 4785

agaattatt  cagggttta  gtgtcaggg  ggtgacttc  cacgccata  tggcactgg  60
ggcaagtcc  tctatgggg  gaaatttga  gatgagaac  tcatcctaa  gcatacggg  120
cctggcatc  tgtccatgg  aaatgctgg  cccaacaca  atggttccc  gtttttcat  180
tgcactgcc  agactgagt  gttggatgg  aagcatgtg  tgtttggca  agtgaaaag  240
aggcatgaa  attgtggaa  gccatggaa  cgctttggg  ccaggaatg  caaagacca  300
caaagaaag  tcaccattg  tgactgtgg  caactcgaa  aagtttgac  tgtgtttta  360
ctttaacca  cagatcatt  cc  382



<210> 4786
<211> 164
<212> PRT
<213> Homo sapiens
<308> P05092
<400> 4786

Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro Leu 
  1               5                  10                  15
Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala 
             20                  25                  30
Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys 
         35                  40                  45
Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly 
     50                  55                  60
Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu 
 65                  70                  75                  80
Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile 
                 85                  90                  95
Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe 
             100                105                110
Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val Phe 
         115                120                125
Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg Phe 
     130                135                140
Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys 
 145                150                155                160
Gly Gln Leu Glu 
                 165



<210> 4787
<211> 492
<212> DNA
<213> Rattus norvegicus
<308> AA818593
<400> 4787

ttttttttt  ttttgttcg  aagcatttt  attatattt  aatcaaata  cattctgag  60
aggcatgta  catacacat  tgtacatag  atctttcaa  aaaaaaatg  acaggtggg  120
cagtgtttt  gtgaaaggc  taaattttt  ttaattgaa  tactagttc  attaaaaac  180
caaaaaact  attgtgtta  agtaactat  tacatagat  aagtgggca  ccaagaggt  240
tagcagcag  cctttaatg  atacaccag  gagtgatat  catcttcct  ccctctgcc  300
ccagcagtt  ccttcgaag  tggcctgtt  ctctgcacc  ttcagggct  atgattcct  360
gcgtagctc  gtctgttgg  ggtttcgtg  agagtcgta  gtgagtcct  ttttctttc  420
ttgttagac  ctgtggtct  gaagaaatc  gttacatac  aaaccacta  tattgccac  480
acagctcct  ga  492



<210> 4788
<211> 282
<212> PRT
<213> Rattus norvegicus
<308> NP_071983
<400> 4788

Met Phe Asp Lys Pro Arg Leu Pro Tyr Val Val Leu Asp Val Ile Cys 
  1               5                  10                  15
Val Leu Leu Ala Gly Leu Pro Phe Ile Ile Leu Thr Ser Arg His Thr 
             20                  25                  30
Pro Phe Gln Arg Gly Val Phe Cys Thr Asp Glu Ser Ile Lys Tyr Pro 
         35                  40                  45
Tyr Arg Glu Asp Thr Ile Pro Tyr Ala Leu Leu Gly Gly Ile Val Ile 
     50                  55                  60
Pro Phe Cys Ile Ile Val Met Ile Thr Gly Glu Thr Leu Ser Val Tyr 
 65                  70                  75                  80
Phe Asn Val Leu His Ser Asn Ser Phe Val Ser Asn His Tyr Ile Ala 
                 85                  90                  95
Thr Ile Tyr Lys Ala Val Gly Ala Phe Leu Phe Gly Ala Ser Ala Ser 
             100                105                110
Gln Ser Leu Thr Asp Ile Ala Lys Tyr Ser Ile Gly Arg Leu Arg Pro 
         115                120                125
His Phe Leu Ala Val Cys Asn Pro Asp Trp Ser Lys Ile Asn Cys Ser 
     130                135                140
Asp Gly Tyr Ile Glu Asn Phe Val Cys Gln Gly Asn Glu Gln Lys Val 
 145                150                155                160
Arg Glu Gly Arg Leu Ser Phe Tyr Ser Gly His Ser Ser Phe Ser Met 
                 165                170                175
Tyr Cys Met Leu Phe Val Ala Leu Tyr Leu Gln Ala Arg Met Lys Gly 
             180                185                190
Asp Trp Ala Arg Leu Leu Arg Pro Met Leu Gln Phe Gly Leu Val Ala 
         195                200                205
Leu Ser Ile Tyr Val Gly Leu Ser Arg Val Ser Asp Tyr Lys His His 
     210                215                220
Trp Ser Asp Val Leu Ile Gly Leu Ile Gln Gly Ala Val Val Ala Ile 
 225                230                235                240
Leu Val Val Leu Tyr Val Thr Asp Phe Phe Lys Thr Thr Glu Ser Asn 
                 245                250                255
Lys Glu Arg Lys Glu Asp Ser His Thr Thr Leu His Glu Thr Thr Asn 
             260                265                270
Arg Gln Ser Tyr Ala Arg Asn His Glu Pro 
         275                280



<210> 4789
<211> 3352
<212> DNA
<213> Homo sapiens
<308> D29641
<400> 4789

ctgctccca  aaatggcgg  cgcattcgg  gatgagctg  tcagcgtgt  cgagggcga  60
tcgaccact  cggcgggaa  caaaaaaga  aaggaaaag  acaagggga  atggaaggg  120
cctccaggg  ctgcagaca  ggcagggaa  cgttttgat  gtaaattac  atcagaatc  180
actaataat  gaaaaaata  gagagatgt  gatttcgaa  gtacagatg  acccatttt  240
ggaaagaag  ccaggatag  agagtcaat  actgaagac  taagtttgg  agacctgat  300
cccagagtc  aggtacaat  agttgaaac  gttgaaggg  gtacacatg  ggttgcact  360
cctgcagaa  aggattatt  accacttaa  ccacgagtt  gaaaagctg  taaggaata  420
ccgttcatt  ttgatgctt  tcaaagaga  gccattcag  gtgttgaca  taatcagtc  480
gttctagta  ctgcacata  ctcagcggg  aaaacagta  gcgccgagt  tgccattgc  540
ttggcctta  gggaaaagc  gcgtgtaat  tttaccagc  caattaagg  tctgagtaa  600
caaaaatac  gtgaaatgt  tgaagaatt  caagatgtt  gtttgatga  tggtgatgt  660
actattaat  ctacggcat  ttgtcttgt  atgaccaca  agattttga  aagtatgct  720
tacagaggt  ccgaagtta  gagagaagt  gcttgggtt  tatttgatg  aattcatta  780
atgagagat  cagaacgtg  tgtagtatg  gaagaaact  ttattttgc  tcctgataa  840
gtccactat  tctttcttt  ggctactat  ccaaatgcc  gacagtttg  tgaatggat  900
tgccattta  ataaacagc  ttgtcatgt  atttacaca  attatcggc  cactccatt  960
caacactac  tttttccag  agggggaga  ggcctgcat  ttgtggttg  tgaaaatgg  1020
gacttcaga  aagataatt  taatactgc  atgcaagtg  ttcgagatg  aggtgattt  1080
gccaaagga  accagaaag  gcggaaagg  ggaacaaaa  gaccatcaa  tgttttcaa  1140
attgtgaag  tgattatgg  aagaaattt  caacctgtg  ttattttca  ttttagtaa  1200
aaagattgt  aagcctatg  acttcaaat  accaaatta  atttcaaca  agatgaaga  1260
aagaagatg  ttgaagaag  attcagtaa  gcaattgat  gcttatccg  tgaagataa  1320
aaactccct  aggtagaac  tgtacttcc  cttttgaag  ggggaattg  tattcacca  1380
ggtggttta  ttcctattt  gaaagaaac  atagaaatt  tcttttctg  aggattgat  1440
aaggcctta  ttgccacgg  gacctttgc  atgggaatt  acatgccag  tagaactgt  1500
ttatttaca  atgcccgca  atttgatgg  aaggatttc  gatggattt  ttctggtga  1560
tacattcag  tgtctggtc  tgctggaag  agaggaatg  atgatagag  aattgtaat  1620
cttatggta  atgaaaaga  gagcccaac  attggaaaa  aattactta  gggctccgc  1680
gatcctcta  atagtgctt  ccatttgac  tacaacatg  ttttgaact  actacgtgt  1740
gaagaaatt  atcctgagt  catgttgga  aaatccttc  accagtttc  gcattatag  1800
gcaattcca  gagtagtag  gaaggtaaa  aattcagaa  aacagtata  taaaatagt  1860
attcccaat  aagaaagtg  ggttatcta  tataagatt  gacagcagc  tgccaaatt  1920
ggtaaagaa  ttgaagaat  tattcacaa  ccaaaatac  gcttacctt  tctacaacc  1980
ggtcgtttg  taaaggtaa  gaatgaagg  gatgacttt  gctggggag  agtggtgaa  2040
ttctcaaaa  agtcaaatg  taagcctaa  tctggtgaa  tggatcctt  gtatgtagt  2100
gaagtactt  tgcgctgta  caaagagag  ttgaaaaat  cagctacag  agctgcaaa  2160
ccagctaaa  ctgatgaga  aggagagat  caggttgtc  cagttttgg  gcatctcct  2220
tctgctatc  gcagtgtta  gctttacat  cctaaagac  ttcggccgg  ggacaatag  2280
cagagtgtt  taaaatcaa  acaggaagt  cagaaacgt  ttcctgacg  catcccctt  2340
ttagaccct  ttgatgata  gggcattca  gatcaaggg  tgaaaaaag  cattcagaa  2400
gtagaagct  ttgagcatc  aatgtattc  catccactt  acaatgatc  aaatttgga  2460
actgtgtat  cgctttgtg  aaaaaaagc  cagattgca  tagatatta  atctgcaaa  2520
cgagaactg  agaaagcaa  aacagtcct  caaatggat  aactcaaat  tcgcaaacg  2580
gttttaaga  ggttgggat  tgctacttc  tctgatgta  tagagatga  aggacgagt  2640
gcttgtgag  taagcagtg  tgatgagct  cttctaact  agatgatgt  taatggcct  2700
ttcaatgac  tttctgcag  acaggcaac  gcattatta  gctgctttg  gtttcaaga  2760
aattctagt  agatgccca  attaacaga  caattagca  gaccacttc  tcaaatgca  2820
gaatgtgct  aaagaattg  aaaagtttc  gcagaagcc  aattggaaa  tgatgagga  2880
acttatcta  gctcattta  acctcactt  atggatgta  tatatacct  ggcaactgg  2940
gctacattt  cccatatct  caaaatgac  gatgtcttt  aaggcagca  aattcgttg  3000
atgaggcgc  tggaagaat  gcttcgaca  atgtgtcaa  cagcaaaag  cattggaaa  3060
actgagctg  aaaataaat  tgcagaagg  atcaccaaa  tcaagagag  tattgtgtt  3120
gctgccagc  tctacttgt  gagtcagct  aaggaatgt  agattttaa  ttattgacc  3180
cctgtttga  tacagttga  tacaaatgc  tgcaagtgt  gatttggtt  tcccataca  3240
tttaatatg  attatattt  aatcaaaca  cattcatag  aagcatatt  catacatgt  3300
tatacataa  cattacatt  ttttaataa  aatgtatac  ggtggggca  tg  3352



<210> 4790
<211> 1046
<212> PRT
<213> Homo sapiens
<308> P42285
<400> 4790

Leu Leu Pro Lys Met Ala Asp Ala Phe Gly Asp Glu Leu Phe Ser Val 
  1               5                  10                  15
Phe Glu Gly Asp Ser Thr Thr Ala Ala Gly Thr Lys Lys Asp Lys Glu 
             20                  25                  30
Lys Asp Lys Gly Lys Trp Lys Gly Pro Pro Gly Ser Ala Asp Lys Ala 
         35                  40                  45
Gly Lys Arg Phe Asp Gly Lys Leu Gln Ser Glu Ser Thr Asn Asn Gly 
     50                  55                  60
Lys Asn Lys Arg Asp Val Asp Phe Glu Gly Thr Asp Glu Pro Ile Phe 
 65                  70                  75                  80
Gly Lys Lys Pro Arg Ile Glu Glu Ser Ile Thr Glu Asp Leu Ser Leu 
                 85                  90                  95
Ala Asp Leu Met Pro Arg Val Lys Val Gln Ser Val Glu Thr Val Glu 
             100                105                110
Gly Cys Thr His Glu Val Ala Leu Pro Ala Glu Glu Asp Tyr Leu Pro 
         115                120                125
Leu Lys Pro Arg Val Gly Lys Ala Ala Lys Glu Tyr Pro Phe Ile Leu 
     130                135                140
Asp Ala Phe Gln Arg Glu Ala Ile Gln Cys Val Asp Asn Asn Gln Ser 
 145                150                155                160
Val Leu Val Ser Ala His Thr Ser Ala Gly Lys Thr Val Cys Ala Glu 
                 165                170                175
Tyr Ala Ile Ala Leu Ala Leu Arg Glu Lys Gln Arg Val Ile Phe Thr 
             180                185                190
Ser Pro Ile Lys Ala Leu Ser Asn Gln Lys Tyr Arg Glu Met Tyr Glu 
         195                200                205
Glu Phe Gln Asp Val Gly Leu Met Thr Gly Asp Val Thr Ile Asn Pro 
     210                215                220
Thr Ala Ser Cys Leu Val Met Thr Thr Glu Ile Leu Arg Ser Met Leu 
 225                230                235                240
Tyr Arg Gly Ser Glu Val Met Arg Glu Val Ala Trp Val Ile Phe Asp 
                 245                250                255
Glu Ile His Tyr Met Arg Asp Ser Glu Arg Gly Val Val Trp Glu Glu 
             260                265                270
Thr Ile Ile Leu Leu Pro Asp Asn Val His Tyr Val Phe Leu Ser Ala 
         275                280                285
Thr Ile Pro Asn Ala Arg Gln Phe Ala Glu Trp Ile Cys His Leu His 
     290                295                300
Lys Gln Pro Cys His Val Ile Tyr Thr Asp Tyr Arg Pro Thr Pro Leu 
 305                310                315                320
Gln His Tyr Ile Phe Pro Ala Gly Gly Asp Gly Leu His Leu Val Val 
                 325                330                335
Asp Glu Asn Gly Asp Phe Arg Glu Asp Asn Phe Asn Thr Ala Met Gln 
             340                345                350
Val Leu Arg Asp Ala Gly Asp Leu Ala Lys Gly Asp Gln Lys Gly Arg 
         355                360                365
Lys Gly Gly Thr Lys Gly Pro Ser Asn Val Phe Lys Ile Val Lys Met 
     370                375                380
Ile Met Glu Arg Asn Phe Gln Pro Val Ile Ile Phe Ser Phe Ser Lys 
 385                390                395                400
Lys Asp Cys Glu Ala Tyr Ala Leu Gln Met Thr Lys Leu Asp Phe Asn 
                 405                410                415
Thr Asp Glu Glu Lys Lys Met Val Glu Glu Val Phe Ser Asn Ala Ile 
             420                425                430
Asp Cys Leu Ser Asp Glu Asp Lys Lys Leu Pro Gln Val Glu His Val 
         435                440                445
Leu Pro Leu Leu Lys Arg Gly Ile Gly Ile His His Gly Gly Leu Leu 
     450                455                460
Pro Ile Leu Lys Glu Thr Ile Glu Ile Leu Phe Ser Glu Gly Leu Ile 
 465                470                475                480
Lys Ala Leu Phe Ala Thr Glu Thr Phe Ala Met Gly Ile Asn Met Pro 
                 485                490                495
Ala Arg Thr Val Leu Phe Thr Asn Ala Arg Lys Phe Asp Gly Lys Asp 
             500                505                510
Phe Arg Trp Ile Ser Ser Gly Glu Tyr Ile Gln Met Ser Gly Arg Ala 
         515                520                525
Gly Arg Arg Gly Met Asp Asp Arg Gly Ile Val Ile Leu Met Val Asp 
     530                535                540
Glu Lys Met Ser Pro Thr Ile Gly Lys Gln Leu Leu Lys Gly Ser Ala 
 545                550                555                560
Asp Pro Leu Asn Ser Ala Phe His Leu Thr Tyr Asn Met Val Leu Asn 
                 565                570                575
Leu Leu Arg Val Glu Glu Ile Asn Pro Glu Tyr Met Leu Glu Lys Ser 
             580                585                590
Phe Tyr Gln Phe Gln His Tyr Arg Ala Ile Pro Gly Val Val Glu Lys 
         595                600                605
Val Lys Asn Ser Glu Glu Gln Tyr Asn Lys Ile Val Ile Pro Asn Glu 
     610                615                620
Glu Ser Val Val Ile Tyr Tyr Lys Ile Arg Gln Gln Leu Ala Lys Leu 
 625                630                635                640
Gly Lys Glu Ile Glu Glu Tyr Ile His Lys Pro Lys Tyr Cys Leu Pro 
                 645                650                655
Phe Leu Gln Pro Gly Arg Leu Val Lys Val Lys Asn Glu Gly Asp Asp 
             660                665                670
Phe Gly Trp Gly Val Val Val Asn Phe Ser Lys Lys Ser Asn Val Lys 
         675                680                685
Pro Asn Ser Gly Glu Leu Asp Pro Leu Tyr Val Val Glu Val Leu Leu 
     690                695                700
Arg Cys Ser Lys Glu Ser Leu Lys Asn Ser Ala Thr Glu Ala Ala Lys 
 705                710                715                720
Pro Ala Lys Pro Asp Glu Lys Gly Glu Met Gln Val Val Pro Val Leu 
                 725                730                735
Val His Leu Leu Ser Ala Ile Ser Ser Val Arg Leu Tyr Ile Pro Lys 
             740                745                750
Asp Leu Arg Pro Val Asp Asn Arg Gln Ser Val Leu Lys Ser Ile Gln 
         755                760                765
Glu Val Gln Lys Arg Phe Pro Asp Gly Ile Pro Leu Leu Asp Pro Ile 
     770                775                780
Asp Asp Met Gly Ile Gln Asp Gln Gly Leu Lys Lys Val Ile Gln Lys 
 785                790                795                800
Val Glu Ala Phe Glu His Arg Met Tyr Ser His Pro Leu His Asn Asp 
                 805                810                815
Pro Asn Leu Glu Thr Val Tyr Thr Leu Cys Glu Lys Lys Ala Gln Ile 
             820                825                830
Ala Ile Asp Ile Lys Ser Ala Lys Arg Glu Leu Lys Lys Ala Arg Thr 
         835                840                845
Val Leu Gln Met Asp Glu Leu Lys Cys Arg Lys Arg Val Leu Arg Arg 
     850                855                860
Leu Gly Phe Ala Thr Ser Ser Asp Val Ile Glu Met Lys Gly Arg Val 
 865                870                875                880
Ala Cys Glu Ile Ser Ser Ala Asp Glu Leu Leu Leu Thr Glu Met Met 
                 885                890                895
Phe Asn Gly Leu Phe Asn Asp Leu Ser Ala Glu Gln Ala Thr Ala Leu 
             900                905                910
Leu Ser Cys Phe Val Phe Gln Glu Asn Ser Ser Glu Met Pro Lys Leu 
         915                920                925
Thr Glu Gln Leu Ala Gly Pro Leu Arg Gln Met Gln Glu Cys Ala Lys 
     930                935                940
Arg Ile Ala Lys Val Ser Ala Glu Ala Lys Leu Glu Ile Asp Glu Glu 
 945                950                955                960
Thr Tyr Leu Ser Ser Phe Lys Pro His Leu Met Asp Val Val Tyr Thr 
                 965                970                975
Trp Ala Thr Gly Ala Thr Phe Ala His Ile Cys Lys Met Thr Asp Val 
             980                985                990
Phe Glu Gly Ser Ile Ile Arg Cys Met Arg Arg Leu Glu Glu Leu Leu 
         995                1000                1005
Arg Gln Met Cys Gln Ala Ala Lys Ala Ile Gly Asn Thr Glu Leu Glu 
     1010                1015                1020
Asn Lys Phe Ala Glu Gly Ile Thr Lys Ile Lys Arg Asp Ile Val Phe 
 1025                1030                1035                1040
Ala Ala Ser Leu Tyr Leu 
                 1045



<210> 4791
<211> 492
<212> DNA
<213> Rattus norvegicus
<308> AA818593
<400> 4791

ttttttttt  ttttgttcg  aagcatttt  attatattt  aatcaaata  cattctgag  60
aggcatgta  catacacat  tgtacatag  atctttcaa  aaaaaaatg  acaggtggg  120
cagtgtttt  gtgaaaggc  taaattttt  ttaattgaa  tactagttc  attaaaaac  180
caaaaaact  attgtgtta  agtaactat  tacatagat  aagtgggca  ccaagaggt  240
tagcagcag  cctttaatg  atacaccag  gagtgatat  catcttcct  ccctctgcc  300
ccagcagtt  ccttcgaag  tggcctgtt  ctctgcacc  ttcagggct  atgattcct  360
gcgtagctc  gtctgttgg  ggtttcgtg  agagtcgta  gtgagtcct  ttttctttc  420
ttgttagac  ctgtggtct  gaagaaatc  gttacatac  aaaccacta  tattgccac  480
acagctcct  ga  492



<210> 4792
<211> 282
<212> PRT
<213> Rattus norvegicus
<308> NP_071983
<400> 4792

Met Phe Asp Lys Pro Arg Leu Pro Tyr Val Val Leu Asp Val Ile Cys 
  1               5                  10                  15
Val Leu Leu Ala Gly Leu Pro Phe Ile Ile Leu Thr Ser Arg His Thr 
             20                  25                  30
Pro Phe Gln Arg Gly Val Phe Cys Thr Asp Glu Ser Ile Lys Tyr Pro 
         35                  40                  45
Tyr Arg Glu Asp Thr Ile Pro Tyr Ala Leu Leu Gly Gly Ile Val Ile 
     50                  55                  60
Pro Phe Cys Ile Ile Val Met Ile Thr Gly Glu Thr Leu Ser Val Tyr 
 65                  70                  75                  80
Phe Asn Val Leu His Ser Asn Ser Phe Val Ser Asn His Tyr Ile Ala 
                 85                  90                  95
Thr Ile Tyr Lys Ala Val Gly Ala Phe Leu Phe Gly Ala Ser Ala Ser 
             100                105                110
Gln Ser Leu Thr Asp Ile Ala Lys Tyr Ser Ile Gly Arg Leu Arg Pro 
         115                120                125
His Phe Leu Ala Val Cys Asn Pro Asp Trp Ser Lys Ile Asn Cys Ser 
     130                135                140
Asp Gly Tyr Ile Glu Asn Phe Val Cys Gln Gly Asn Glu Gln Lys Val 
 145                150                155                160
Arg Glu Gly Arg Leu Ser Phe Tyr Ser Gly His Ser Ser Phe Ser Met 
                 165                170                175
Tyr Cys Met Leu Phe Val Ala Leu Tyr Leu Gln Ala Arg Met Lys Gly 
             180                185                190
Asp Trp Ala Arg Leu Leu Arg Pro Met Leu Gln Phe Gly Leu Val Ala 
         195                200                205
Leu Ser Ile Tyr Val Gly Leu Ser Arg Val Ser Asp Tyr Lys His His 
     210                215                220
Trp Ser Asp Val Leu Ile Gly Leu Ile Gln Gly Ala Val Val Ala Ile 
 225                230                235                240
Leu Val Val Leu Tyr Val Thr Asp Phe Phe Lys Thr Thr Glu Ser Asn 
                 245                250                255
Lys Glu Arg Lys Glu Asp Ser His Thr Thr Leu His Glu Thr Thr Asn 
             260                265                270
Arg Gln Ser Tyr Ala Arg Asn His Glu Pro 
         275                280



<210> 4793
<211> 3352
<212> DNA
<213> Homo sapiens
<308> D29641
<400> 4793

ctgctccca  aaatggcgg  cgcattcgg  gatgagctg  tcagcgtgt  cgagggcga  60
tcgaccact  cggcgggaa  caaaaaaga  aaggaaaag  acaagggga  atggaaggg  120
cctccaggg  ctgcagaca  ggcagggaa  cgttttgat  gtaaattac  atcagaatc  180
actaataat  gaaaaaata  gagagatgt  gatttcgaa  gtacagatg  acccatttt  240
ggaaagaag  ccaggatag  agagtcaat  actgaagac  taagtttgg  agacctgat  300
cccagagtc  aggtacaat  agttgaaac  gttgaaggg  gtacacatg  ggttgcact  360
cctgcagaa  aggattatt  accacttaa  ccacgagtt  gaaaagctg  taaggaata  420
ccgttcatt  ttgatgctt  tcaaagaga  gccattcag  gtgttgaca  taatcagtc  480
gttctagta  ctgcacata  ctcagcggg  aaaacagta  gcgccgagt  tgccattgc  540
ttggcctta  gggaaaagc  gcgtgtaat  tttaccagc  caattaagg  tctgagtaa  600
caaaaatac  gtgaaatgt  tgaagaatt  caagatgtt  gtttgatga  tggtgatgt  660
actattaat  ctacggcat  ttgtcttgt  atgaccaca  agattttga  aagtatgct  720
tacagaggt  ccgaagtta  gagagaagt  gcttgggtt  tatttgatg  aattcatta  780
atgagagat  cagaacgtg  tgtagtatg  gaagaaact  ttattttgc  tcctgataa  840
gtccactat  tctttcttt  ggctactat  ccaaatgcc  gacagtttg  tgaatggat  900
tgccattta  ataaacagc  ttgtcatgt  atttacaca  attatcggc  cactccatt  960
caacactac  tttttccag  agggggaga  ggcctgcat  ttgtggttg  tgaaaatgg  1020
gacttcaga  aagataatt  taatactgc  atgcaagtg  ttcgagatg  aggtgattt  1080
gccaaagga  accagaaag  gcggaaagg  ggaacaaaa  gaccatcaa  tgttttcaa  1140
attgtgaag  tgattatgg  aagaaattt  caacctgtg  ttattttca  ttttagtaa  1200
aaagattgt  aagcctatg  acttcaaat  accaaatta  atttcaaca  agatgaaga  1260
aagaagatg  ttgaagaag  attcagtaa  gcaattgat  gcttatccg  tgaagataa  1320
aaactccct  aggtagaac  tgtacttcc  cttttgaag  ggggaattg  tattcacca  1380
ggtggttta  ttcctattt  gaaagaaac  atagaaatt  tcttttctg  aggattgat  1440
aaggcctta  ttgccacgg  gacctttgc  atgggaatt  acatgccag  tagaactgt  1500
ttatttaca  atgcccgca  atttgatgg  aaggatttc  gatggattt  ttctggtga  1560
tacattcag  tgtctggtc  tgctggaag  agaggaatg  atgatagag  aattgtaat  1620
cttatggta  atgaaaaga  gagcccaac  attggaaaa  aattactta  gggctccgc  1680
gatcctcta  atagtgctt  ccatttgac  tacaacatg  ttttgaact  actacgtgt  1740
gaagaaatt  atcctgagt  catgttgga  aaatccttc  accagtttc  gcattatag  1800
gcaattcca  gagtagtag  gaaggtaaa  aattcagaa  aacagtata  taaaatagt  1860
attcccaat  aagaaagtg  ggttatcta  tataagatt  gacagcagc  tgccaaatt  1920
ggtaaagaa  ttgaagaat  tattcacaa  ccaaaatac  gcttacctt  tctacaacc  1980
ggtcgtttg  taaaggtaa  gaatgaagg  gatgacttt  gctggggag  agtggtgaa  2040
ttctcaaaa  agtcaaatg  taagcctaa  tctggtgaa  tggatcctt  gtatgtagt  2100
gaagtactt  tgcgctgta  caaagagag  ttgaaaaat  cagctacag  agctgcaaa  2160
ccagctaaa  ctgatgaga  aggagagat  caggttgtc  cagttttgg  gcatctcct  2220
tctgctatc  gcagtgtta  gctttacat  cctaaagac  ttcggccgg  ggacaatag  2280
cagagtgtt  taaaatcaa  acaggaagt  cagaaacgt  ttcctgacg  catcccctt  2340
ttagaccct  ttgatgata  gggcattca  gatcaaggg  tgaaaaaag  cattcagaa  2400
gtagaagct  ttgagcatc  aatgtattc  catccactt  acaatgatc  aaatttgga  2460
actgtgtat  cgctttgtg  aaaaaaagc  cagattgca  tagatatta  atctgcaaa  2520
cgagaactg  agaaagcaa  aacagtcct  caaatggat  aactcaaat  tcgcaaacg  2580
gttttaaga  ggttgggat  tgctacttc  tctgatgta  tagagatga  aggacgagt  2640
gcttgtgag  taagcagtg  tgatgagct  cttctaact  agatgatgt  taatggcct  2700
ttcaatgac  tttctgcag  acaggcaac  gcattatta  gctgctttg  gtttcaaga  2760
aattctagt  agatgccca  attaacaga  caattagca  gaccacttc  tcaaatgca  2820
gaatgtgct  aaagaattg  aaaagtttc  gcagaagcc  aattggaaa  tgatgagga  2880
acttatcta  gctcattta  acctcactt  atggatgta  tatatacct  ggcaactgg  2940
gctacattt  cccatatct  caaaatgac  gatgtcttt  aaggcagca  aattcgttg  3000
atgaggcgc  tggaagaat  gcttcgaca  atgtgtcaa  cagcaaaag  cattggaaa  3060
actgagctg  aaaataaat  tgcagaagg  atcaccaaa  tcaagagag  tattgtgtt  3120
gctgccagc  tctacttgt  gagtcagct  aaggaatgt  agattttaa  ttattgacc  3180
cctgtttga  tacagttga  tacaaatgc  tgcaagtgt  gatttggtt  tcccataca  3240
tttaatatg  attatattt  aatcaaaca  cattcatag  aagcatatt  catacatgt  3300
tatacataa  cattacatt  ttttaataa  aatgtatac  ggtggggca  tg  3352



<210> 4794
<211> 1046
<212> PRT
<213> Homo sapiens
<308> P42285
<400> 4794

Leu Leu Pro Lys Met Ala Asp Ala Phe Gly Asp Glu Leu Phe Ser Val 
  1               5                  10                  15
Phe Glu Gly Asp Ser Thr Thr Ala Ala Gly Thr Lys Lys Asp Lys Glu 
             20                  25                  30
Lys Asp Lys Gly Lys Trp Lys Gly Pro Pro Gly Ser Ala Asp Lys Ala 
         35                  40                  45
Gly Lys Arg Phe Asp Gly Lys Leu Gln Ser Glu Ser Thr Asn Asn Gly 
     50                  55                  60
Lys Asn Lys Arg Asp Val Asp Phe Glu Gly Thr Asp Glu Pro Ile Phe 
 65                  70                  75                  80
Gly Lys Lys Pro Arg Ile Glu Glu Ser Ile Thr Glu Asp Leu Ser Leu 
                 85                  90                  95
Ala Asp Leu Met Pro Arg Val Lys Val Gln Ser Val Glu Thr Val Glu 
             100                105                110
Gly Cys Thr His Glu Val Ala Leu Pro Ala Glu Glu Asp Tyr Leu Pro 
         115                120                125
Leu Lys Pro Arg Val Gly Lys Ala Ala Lys Glu Tyr Pro Phe Ile Leu 
     130                135                140
Asp Ala Phe Gln Arg Glu Ala Ile Gln Cys Val Asp Asn Asn Gln Ser 
 145                150                155                160
Val Leu Val Ser Ala His Thr Ser Ala Gly Lys Thr Val Cys Ala Glu 
                 165                170                175
Tyr Ala Ile Ala Leu Ala Leu Arg Glu Lys Gln Arg Val Ile Phe Thr 
             180                185                190
Ser Pro Ile Lys Ala Leu Ser Asn Gln Lys Tyr Arg Glu Met Tyr Glu 
         195                200                205
Glu Phe Gln Asp Val Gly Leu Met Thr Gly Asp Val Thr Ile Asn Pro 
     210                215                220
Thr Ala Ser Cys Leu Val Met Thr Thr Glu Ile Leu Arg Ser Met Leu 
 225                230                235                240
Tyr Arg Gly Ser Glu Val Met Arg Glu Val Ala Trp Val Ile Phe Asp 
                 245                250                255
Glu Ile His Tyr Met Arg Asp Ser Glu Arg Gly Val Val Trp Glu Glu 
             260                265                270
Thr Ile Ile Leu Leu Pro Asp Asn Val His Tyr Val Phe Leu Ser Ala 
         275                280                285
Thr Ile Pro Asn Ala Arg Gln Phe Ala Glu Trp Ile Cys His Leu His 
     290                295                300
Lys Gln Pro Cys His Val Ile Tyr Thr Asp Tyr Arg Pro Thr Pro Leu 
 305                310                315                320
Gln His Tyr Ile Phe Pro Ala Gly Gly Asp Gly Leu His Leu Val Val 
                 325                330                335
Asp Glu Asn Gly Asp Phe Arg Glu Asp Asn Phe Asn Thr Ala Met Gln 
             340                345                350
Val Leu Arg Asp Ala Gly Asp Leu Ala Lys Gly Asp Gln Lys Gly Arg 
         355                360                365
Lys Gly Gly Thr Lys Gly Pro Ser Asn Val Phe Lys Ile Val Lys Met 
     370                375                380
Ile Met Glu Arg Asn Phe Gln Pro Val Ile Ile Phe Ser Phe Ser Lys 
 385                390                395                400
Lys Asp Cys Glu Ala Tyr Ala Leu Gln Met Thr Lys Leu Asp Phe Asn 
                 405                410                415
Thr Asp Glu Glu Lys Lys Met Val Glu Glu Val Phe Ser Asn Ala Ile 
             420                425                430
Asp Cys Leu Ser Asp Glu Asp Lys Lys Leu Pro Gln Val Glu His Val 
         435                440                445
Leu Pro Leu Leu Lys Arg Gly Ile Gly Ile His His Gly Gly Leu Leu 
     450                455                460
Pro Ile Leu Lys Glu Thr Ile Glu Ile Leu Phe Ser Glu Gly Leu Ile 
 465                470                475                480
Lys Ala Leu Phe Ala Thr Glu Thr Phe Ala Met Gly Ile Asn Met Pro 
                 485                490                495
Ala Arg Thr Val Leu Phe Thr Asn Ala Arg Lys Phe Asp Gly Lys Asp 
             500                505                510
Phe Arg Trp Ile Ser Ser Gly Glu Tyr Ile Gln Met Ser Gly Arg Ala 
         515                520                525
Gly Arg Arg Gly Met Asp Asp Arg Gly Ile Val Ile Leu Met Val Asp 
     530                535                540
Glu Lys Met Ser Pro Thr Ile Gly Lys Gln Leu Leu Lys Gly Ser Ala 
 545                550                555                560
Asp Pro Leu Asn Ser Ala Phe His Leu Thr Tyr Asn Met Val Leu Asn 
                 565                570                575
Leu Leu Arg Val Glu Glu Ile Asn Pro Glu Tyr Met Leu Glu Lys Ser 
             580                585                590
Phe Tyr Gln Phe Gln His Tyr Arg Ala Ile Pro Gly Val Val Glu Lys 
         595                600                605
Val Lys Asn Ser Glu Glu Gln Tyr Asn Lys Ile Val Ile Pro Asn Glu 
     610                615                620
Glu Ser Val Val Ile Tyr Tyr Lys Ile Arg Gln Gln Leu Ala Lys Leu 
 625                630                635                640
Gly Lys Glu Ile Glu Glu Tyr Ile His Lys Pro Lys Tyr Cys Leu Pro 
                 645                650                655
Phe Leu Gln Pro Gly Arg Leu Val Lys Val Lys Asn Glu Gly Asp Asp 
             660                665                670
Phe Gly Trp Gly Val Val Val Asn Phe Ser Lys Lys Ser Asn Val Lys 
         675                680                685
Pro Asn Ser Gly Glu Leu Asp Pro Leu Tyr Val Val Glu Val Leu Leu 
     690                695                700
Arg Cys Ser Lys Glu Ser Leu Lys Asn Ser Ala Thr Glu Ala Ala Lys 
 705                710                715                720
Pro Ala Lys Pro Asp Glu Lys Gly Glu Met Gln Val Val Pro Val Leu 
                 725                730                735
Val His Leu Leu Ser Ala Ile Ser Ser Val Arg Leu Tyr Ile Pro Lys 
             740                745                750
Asp Leu Arg Pro Val Asp Asn Arg Gln Ser Val Leu Lys Ser Ile Gln 
         755                760                765
Glu Val Gln Lys Arg Phe Pro Asp Gly Ile Pro Leu Leu Asp Pro Ile 
     770                775                780
Asp Asp Met Gly Ile Gln Asp Gln Gly Leu Lys Lys Val Ile Gln Lys 
 785                790                795                800
Val Glu Ala Phe Glu His Arg Met Tyr Ser His Pro Leu His Asn Asp 
                 805                810                815
Pro Asn Leu Glu Thr Val Tyr Thr Leu Cys Glu Lys Lys Ala Gln Ile 
             820                825                830
Ala Ile Asp Ile Lys Ser Ala Lys Arg Glu Leu Lys Lys Ala Arg Thr 
         835                840                845
Val Leu Gln Met Asp Glu Leu Lys Cys Arg Lys Arg Val Leu Arg Arg 
     850                855                860
Leu Gly Phe Ala Thr Ser Ser Asp Val Ile Glu Met Lys Gly Arg Val 
 865                870                875                880
Ala Cys Glu Ile Ser Ser Ala Asp Glu Leu Leu Leu Thr Glu Met Met 
                 885                890                895
Phe Asn Gly Leu Phe Asn Asp Leu Ser Ala Glu Gln Ala Thr Ala Leu 
             900                905                910
Leu Ser Cys Phe Val Phe Gln Glu Asn Ser Ser Glu Met Pro Lys Leu 
         915                920                925
Thr Glu Gln Leu Ala Gly Pro Leu Arg Gln Met Gln Glu Cys Ala Lys 
     930                935                940
Arg Ile Ala Lys Val Ser Ala Glu Ala Lys Leu Glu Ile Asp Glu Glu 
 945                950                955                960
Thr Tyr Leu Ser Ser Phe Lys Pro His Leu Met Asp Val Val Tyr Thr 
                 965                970                975
Trp Ala Thr Gly Ala Thr Phe Ala His Ile Cys Lys Met Thr Asp Val 
             980                985                990
Phe Glu Gly Ser Ile Ile Arg Cys Met Arg Arg Leu Glu Glu Leu Leu 
         995                1000                1005
Arg Gln Met Cys Gln Ala Ala Lys Ala Ile Gly Asn Thr Glu Leu Glu 
     1010                1015                1020
Asn Lys Phe Ala Glu Gly Ile Thr Lys Ile Lys Arg Asp Ile Val Phe 
 1025                1030                1035                1040
Ala Ala Ser Leu Tyr Leu 
                 1045



<210> 4795
<211> 618
<212> DNA
<213> Rattus norvegicus
<308> AA818677
<400> 4795

ttttttttt  tttttgtat  tcagaagca  ttggtttta  tgcacggaa  caatcgaaa  60
tggacttca  tggacagca  accctggcc  ggttcagcg  ccagcgccc  gcctcacct  120
ctgcagctc  tccaggagc  tgtaccggg  aagggcctg  ccgctcctt  ggaaaacaa  180
aaggcattc  ggaataggt  acaacattt  aagcataat  catttctaa  tgctcattc  240
ttactgcgg  cacctgtcg  taggacata  gtaaatgca  ttacttgga  aggaggggg  300
gcagttttt  gtcacgcgt  ttacgtgga  cgttcagca  tacatcacg  tcggctacg  360
taagctatc  taattgtcc  tcacctggg  agggctttc  gtgttgggg  ggcacggct  420
agggttatc  tctcttgct  acttaatcc  aatagaaat  cctgtttgg  gagggcggg  480
ccgccatct  agtggtgtt  cttcttacg  agggaaagg  agaaataaa  tttattaca  540
caacccttg  gtaccgggg  cgtcctgag  ttctttggc  attccgggt  gtcctctcg  600
cctcttact  gtctccct  618



<210> 4796
<211> 831
<212> PRT
<213> Rattus norvegicus
<308> P16884
<400> 4796

His Gln Glu Glu Val Gly Glu Leu Leu Gly Gln Ile Gln Gly Cys Gly 
  1               5                  10                  15
Ala Ala Gln Ala Gln Ala Gln Ala Glu Ala Arg Asp Ala Leu Lys Cys 
             20                  25                  30
Asp Val Thr Ser Ala Leu Arg Glu Ile Arg Ala Gln Leu Glu Gly His 
         35                  40                  45
Thr Val Gln Ser Thr Leu Gln Ser Glu Glu Trp Phe Arg Val Arg Leu 
     50                  55                  60
Asp Arg Leu Ser Glu Ala Ala Lys Val Asn Thr Asp Ala Met Arg Ser 
 65                  70                  75                  80
Ala Gln Glu Glu Ile Thr Glu Tyr Arg Arg Gln Leu Gln Ala Arg Thr 
                 85                  90                  95
Thr Glu Leu Glu Ala Leu Lys Ser Thr Lys Glu Ser Leu Glu Arg Gln 
             100                105                110
Arg Ser Glu Leu Glu Asp Arg His Gln Val Asp Met Ala Ser Tyr Gln 
         115                120                125
Asp Ala Ile Gln Gln Leu Asp Asn Glu Leu Arg Asn Thr Lys Trp Glu 
     130                135                140
Met Ala Ala Gln Leu Arg Glu Tyr Gln Asp Leu Leu Asn Val Lys Met 
 145                150                155                160
Ala Leu Asp Leu Glu Ile Ala Ala Tyr Arg Lys Leu Leu Glu Gly Glu 
                 165                170                175
Glu Cys Arg Ile Gly Phe Gly Pro Ile Pro Phe Ser Leu Thr Glu Gly 
             180                185                190
Leu Pro Lys Ile Pro Ser Met Ser Thr His Ile Lys Val Lys Ser Glu 
         195                200                205
Glu Lys Ile Lys Val Val Glu Lys Ser Glu Lys Glu Thr Val Ile Val 
     210                215                220
Glu Glu Gln Thr Glu Glu Ile Gln Val Thr Glu Glu Val Thr Glu Glu 
 225                230                235                240
Glu Asp Lys Glu Ala Gln Gly Glu Glu Glu Glu Glu Ala Glu Glu Gly 
                 245                250                255
Gly Glu Glu Ala Ala Thr Thr Ser Pro Pro Ala Glu Glu Ala Ala Ser 
             260                265                270
Pro Glu Lys Glu Thr Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro 
         275                280                285
Ala Glu Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro Ala Glu Ala Lys 
     290                295                300
Ser Pro Ala Glu Val Lys Ser Pro Ala Val Ala Lys Ser Pro Ala Glu 
 305                310                315                320
Val Lys Ser Pro Ala Glu Val Lys Ser Pro Ala Glu Ala Lys Ser Pro 
                 325                330                335
Ala Glu Ala Lys Ser Pro Ala Glu Val Lys Ser Pro Ala Thr Val Lys 
             340                345                350
Ser Pro Gly Glu Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro Ala Glu 
         355                360                365
Val Lys Ser Pro Ala Glu Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro 
     370                375                380
Ala Ser Val Lys Ser Pro Gly Glu Ala Lys Ser Pro Ala Glu Ala Lys 
 385                390                395                400
Ser Pro Ala Glu Val Lys Ser Pro Ala Thr Val Lys Ser Pro Val Glu 
                 405                410                415
Ala Lys Ser Pro Ala Glu Val Lys Ser Pro Val Thr Val Lys Ser Pro 
             420                425                430
Ala Glu Ala Lys Ser Pro Val Glu Val Lys Ser Pro Ala Ser Val Lys 
         435                440                445
Ser Pro Ser Glu Ala Lys Ser Pro Ala Gly Ala Lys Ser Pro Ala Glu 
     450                455                460
Ala Lys Ser Pro Val Val Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro 
 465                470                475                480
Ala Gly Ala Lys Pro Pro Ala Glu Ala Lys Ser Pro Ala Glu Ala Lys 
                 485                490                495
Ser Pro Ala Glu Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro Ala Glu 
             500                505                510
Ala Lys Ser Pro Val Glu Val Lys Ser Pro Glu Lys Ala Lys Ser Pro 
         515                520                525
Val Lys Glu Gly Ala Lys Ser Leu Ala Glu Ala Lys Ser Pro Glu Lys 
     530                535                540
Ala Lys Ser Pro Val Lys Glu Glu Ile Lys Pro Pro Ala Glu Val Lys 
 545                550                555                560
Ser Pro Glu Lys Ala Lys Ser Pro Met Arg Lys Glu Ala Lys Ser Pro 
                 565                570                575
Glu Lys Ala Lys Thr Leu Asp Val Lys Ser Pro Glu Ala Lys Pro Pro 
             580                585                590
Ala Lys Glu Glu Ala Lys Arg Pro Ala Asp Ile Arg Ser Pro Glu Gln 
         595                600                605
Val Lys Ser Pro Ala Lys Glu Glu Ala Lys Ser Pro Glu Lys Glu Glu 
     610                615                620
Thr Arg Thr Glu Lys Val Ala Pro Lys Lys Glu Glu Val Lys Ser Pro 
 625                630                635                640
Val Glu Glu Val Lys Ala Lys Glu Pro Pro Lys Lys Val Glu Glu Glu 
                 645                650                655
Lys Thr Pro Ala Thr Pro Lys Thr Glu Val Lys Glu Ser Lys Lys Asp 
             660                665                670
Glu Ala Pro Lys Glu Ala Gln Lys Pro Lys Ala Glu Glu Lys Glu Pro 
         675                680                685
Leu Thr Glu Lys Pro Lys Asp Ser Pro Gly Glu Ala Lys Lys Glu Glu 
     690                695                700
Ala Lys Glu Lys Lys Ala Ala Ala Pro Glu Glu Glu Thr Pro Ala Lys 
 705                710                715                720
Leu Gly Val Lys Glu Glu Ala Lys Pro Lys Glu Lys Ala Glu Asp Ala 
                 725                730                735
Lys Ala Lys Glu Pro Ser Lys Pro Ser Glu Lys Glu Lys Pro Lys Lys 
             740                745                750
Glu Glu Val Pro Ala Ala Pro Glu Lys Lys Asp Thr Lys Glu Glu Lys 
         755                760                765
Thr Thr Glu Ser Lys Lys Arg Glu Glu Lys Pro Lys Met Glu Ala Lys 
     770                775                780
Ala Lys Glu Glu Asp Lys Gly Leu Pro Gln Glu Pro Ser Lys Pro Lys 
 785                790                795                800
Thr Glu Lys Ala Glu Lys Ser Ser Ser Thr Asp Gln Lys Asp Ser Gln 
                 805                810                815
Pro Ser Glu Lys Ala Pro Glu Asp Lys Ala Ala Lys Gly Asp Lys 
             820                825                830



<210> 4797
<211> 2313
<212> DNA
<213> Homo sapiens
<308> BC014185
<400> 4797

ggcacgagg  ccccgtccc  gcctcgcgc  cctgctcag  ccatgatga  cttcggcgg  60
gcggacgcg  tgctgggcg  cccgttcgc  ccgctgcat  gcggcggca  cctccacta  120
gcgctagcc  gaaagggtg  cgcaggcgg  acgcgctcc  ccgctggct  ctccagcgg  180
ttccactcg  ggacacgga  gtccgtgag  tccgtgtcc  cctcgccca  ccgcttccg  240
ggcgcaggc  ccgcctcaa  caccgactc  ctggacacg  tgagcaacg  gccggaggg  300
tgcatggtg  cggtggcca  ctcacgcag  gagaaggag  agctgcagg  gctgaacga  360
cgcttcgcc  ggtacatcg  caaggtgcg  cagctggag  cgcacaacc  cagcctgga  420
ggcgaggct  cggcgctgc  gcagcagca  gcgggccgc  ccgctatgg  cgagctgta  480
gagcgcgag  tccgcgaga  gcgcggcgc  gtgctgcgc  tgggcgcgg  gcgcggtca  540
ctacgcctg  agcaggagc  cctgctcga  gacatcgcg  acgtgcgcc  gcgcctaga  600
gacgaggcc  ggcagcgag  ggaggccga  gcggcggcc  gcgcgctgg  gcgcttcgc  660
caggaggcc  aggcggcgc  cgtggacct  cagaagaag  cgcaggcgc  gcaggagga  720
tgcggctac  tgcggcgcc  ccaccagga  gaggtgggc  agctgctcg  ccagatcca  780
ggctccggc  ccgcgcagg  gcagatgca  gccgagacg  gcgacgccc  gaagtgcga  840
gtgacgtcg  cgctgcgcg  gattcgcgc  cagcttgaa  gccacgcgg  gcagagcac  900
ctgcagtcc  aggagtggt  ccgagaaga  ggaacctgc  gtcgaaaag  ccaaagaat  960
caaagttga  gccaagaag  aagaggctg  agataagaa  aaagtcccc  ccccagaga  1020
ggaggctcc  gccaaggtg  aggtgaagg  agacgctaa  cccaaagaa  agacagagg  1080
ggccaagaa  gaaccagat  atgccaagg  caaggaacc  agcaaacca  cagagaaga  1140
ggaggcagc  ccggagaaa  aagacacca  ggaggagaa  gccaagaag  ctgaggaga  1200
acccaagac  gaggccaaa  ccaaggaag  tgacaagac  ctctcaaaa  agcctagca  1260
gcctaaggc  gaaaaggct  aaaaatcct  cagcacaga  caaaaagac  gcaagcctc  1320
agagaaggc  aagtcccca  agaaggcca  gactcttga  gtgaagtct  cagaagcca  1380
gactccagc  aaggaggaa  caaggtccc  tgcagacaa  ttccctgaa  aggccaaaa  1440
ccctgtcaa  gaggaggtc  agtccccag  gaaggcgaa  tctcccctg  aggaggatg  1500
caaggcccc  gagaaggag  tcccaaaaa  ggaagaggt  aagtcccca  tgaaggagg  1560
ggagaagcc  caggaggtg  aagtcaaag  gcccccaaa  aaggcagag  aagagaaag  1620
ccctgccac  ccaaaaaca  aggagaaga  ggacagcaa  aaagaggag  cacccaaga  1680
ggaggctcc  aagcccaag  tggaggaga  gaaggaacc  gctgtcgaa  agcccaaag  1740
aactcagaa  agtcccgga  ctcaaggat  agagtaaca  aattttcac  ttttctgtc  1800
ttatgtaag  agaaactgc  tagatgacg  ggcctcctt  ttcaaacag  aatttctgt  1860
agcaatatg  tagcaagag  gggcactcc  aggcccctg  ccccatgcc  tccccaggc  1920
atggacaat  atgatagct  atgtagctg  atgtgatac  tgccgaatg  cacacgtaa  1980
cacttgact  taaaaactg  ccccctcct  tccaaataa  tgcatttat  gcctctatg  2040
gcaactgac  gatgaccgc  ataatgaat  agcagttag  aatacatta  gcttgagat  2100
tcttaacct  ttcccaaat  ccttctgtt  tccaaagga  tggtcaagc  cttgcccag  2160
gctctctat  ctggaagag  ggtccaggt  gggccgggc  ctggccact  aattatgcc  2220
gggcgcact  tccactgga  ttcactttc  attgcttct  tgcaataaa  ccaagtgct  2280
ataaaatga  aaaaaaaaa  aaaaaaaaa  aaa  2313



<210> 4798
<211> 1020
<212> PRT
<213> Homo sapiens
<308> XP_037942
<400> 4798

Met Met Ser Phe Gly Gly Ala Asp Ala Leu Leu Gly Ala Pro Phe Ala 
  1               5                  10                  15
Pro Leu His Gly Gly Gly Ser Leu His Tyr Ala Leu Ala Arg Lys Gly 
             20                  25                  30
Gly Ala Gly Gly Thr Arg Ser Ala Ala Gly Ser Ser Ser Gly Phe His 
         35                  40                  45
Ser Trp Thr Arg Thr Ser Val Ser Ser Val Ser Ala Ser Pro Ser Arg 
     50                  55                  60
Phe Arg Gly Ala Gly Ala Ala Ser Ser Thr Asp Ser Leu Asp Thr Leu 
 65                  70                  75                  80
Ser Asn Gly Pro Glu Gly Cys Met Val Ala Val Ala Thr Ser Arg Ser 
                 85                  90                  95
Glu Lys Glu Gln Leu Gln Ala Leu Asn Asp Arg Phe Ala Gly Tyr Ile 
             100                105                110
Asp Lys Val Arg Gln Leu Glu Ala His Asn Arg Ser Leu Glu Gly Glu 
         115                120                125
Ala Ala Ala Leu Arg Gln Gln Gln Ala Gly Arg Ser Ala Met Gly Glu 
     130                135                140
Leu Tyr Glu Arg Glu Val Arg Glu Met Arg Gly Ala Val Leu Arg Leu 
 145                150                155                160
Gly Ala Ala Arg Gly Gln Leu Arg Leu Glu Gln Glu His Leu Leu Glu 
                 165                170                175
Asp Ile Ala His Val Arg Gln Arg Leu Asp Asp Glu Ala Arg Gln Arg 
             180                185                190
Glu Glu Ala Glu Ala Ala Ala Arg Ala Leu Ala Arg Phe Ala Gln Glu 
         195                200                205
Ala Glu Ala Ala Arg Val Asp Leu Gln Lys Lys Ala Gln Ala Leu Gln 
     210                215                220
Glu Glu Cys Gly Tyr Leu Arg Arg His His Gln Glu Glu Val Gly Glu 
 225                230                235                240
Leu Leu Gly Gln Ile Gln Gly Ser Gly Ala Ala Gln Ala Gln Met Gln 
                 245                250                255
Ala Glu Thr Arg Asp Ala Leu Lys Cys Asp Val Thr Ser Ala Leu Arg 
             260                265                270
Glu Ile Arg Ala Gln Leu Glu Gly His Ala Val Gln Ser Thr Leu Gln 
         275                280                285
Ser Glu Glu Trp Phe Arg Val Arg Leu Asp Arg Leu Ser Glu Ala Ala 
     290                295                300
Lys Val Asn Thr Asp Ala Met Arg Ser Ala Gln Glu Glu Ile Thr Glu 
 305                310                315                320
Tyr Arg Arg Gln Leu Gln Ala Arg Thr Thr Glu Leu Glu Ala Leu Lys 
                 325                330                335
Ser Thr Lys Asp Ser Leu Glu Arg Gln Arg Ser Glu Leu Glu Asp Arg 
             340                345                350
His Gln Ala Asp Ile Ala Ser Tyr Gln Glu Ala Ile Gln Gln Leu Asp 
         355                360                365
Ala Glu Leu Arg Asn Thr Lys Trp Glu Met Ala Ala Gln Leu Arg Glu 
     370                375                380
Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala 
 385                390                395                400
Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Ile Gly Phe Gly 
                 405                410                415
Pro Ile Pro Phe Ser Leu Pro Glu Gly Leu Pro Lys Ile Pro Ser Val 
             420                425                430
Ser Thr His Ile Lys Val Lys Ser Glu Glu Lys Ile Lys Val Val Glu 
         435                440                445
Lys Ser Glu Lys Glu Thr Val Ile Val Glu Glu Gln Thr Glu Glu Thr 
     450                455                460
Gln Val Thr Glu Glu Val Thr Glu Glu Glu Glu Lys Glu Ala Lys Glu 
 465                470                475                480
Glu Glu Gly Lys Glu Glu Glu Gly Gly Glu Glu Glu Glu Ala Glu Gly 
                 485                490                495
Gly Glu Glu Glu Thr Lys Ser Pro Pro Ala Glu Glu Ala Ala Ser Pro 
             500                505                510
Glu Lys Glu Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro Ala 
         515                520                525
Glu Ala Lys Ser Pro Glu Lys Glu Glu Ala Lys Ser Pro Ala Glu Val 
     530                535                540
Lys Ser Pro Glu Lys Ala Lys Ser Pro Ala Lys Glu Glu Ala Lys Ser 
 545                550                555                560
Pro Pro Glu Ala Lys Ser Pro Glu Lys Glu Glu Ala Lys Ser Pro Ala 
                 565                570                575
Glu Val Lys Ser Pro Glu Lys Ala Lys Ser Pro Ala Lys Glu Glu Ala 
             580                585                590
Lys Ser Pro Ala Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val 
         595                600                605
Lys Glu Glu Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro Val Lys Glu 
     610                615                620
Glu Ala Lys Ser Pro Ala Glu Val Lys Ser Pro Glu Lys Ala Lys Ser 
 625                630                635                640
Pro Thr Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Glu 
                 645                650                655
Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val Lys Ala 
             660                665                670
Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val Lys Ala Glu Ala 
         675                680                685
Lys Ser Pro Glu Lys Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Ser 
     690                695                700
Pro Glu Lys Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro Glu 
 705                710                715                720
Lys Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Thr Pro Glu Lys Ala 
                 725                730                735
Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser 
             740                745                750
Pro Glu Lys Ala Lys Thr Leu Asp Val Lys Ser Pro Glu Ala Lys Thr 
         755                760                765
Pro Ala Lys Glu Glu Ala Arg Ser Pro Ala Asp Lys Phe Pro Glu Lys 
     770                775                780
Ala Lys Ser Pro Val Lys Glu Glu Val Lys Ser Pro Glu Lys Ala Lys 
 785                790                795                800
Ser Pro Leu Lys Ala Asp Ala Lys Ala Pro Glu Lys Glu Ile Pro Lys 
                 805                810                815
Lys Glu Glu Val Lys Ser Pro Val Lys Glu Glu Glu Lys Pro Gln Glu 
             820                825                830
Val Lys Val Lys Glu Pro Pro Lys Lys Ala Glu Glu Glu Lys Ala Pro 
         835                840                845
Ala Thr Pro Lys Thr Glu Glu Lys Lys Asp Ser Lys Lys Glu Glu Ala 
     850                855                860
Pro Lys Lys Glu Ala Pro Lys Pro Lys Val Glu Glu Lys Lys Glu Pro 
 865                870                875                880
Ala Val Glu Lys Pro Lys Glu Ser Lys Val Glu Ala Lys Lys Glu Glu 
                 885                890                895
Ala Glu Asp Lys Lys Lys Val Pro Thr Pro Glu Lys Glu Ala Pro Ala 
             900                905                910
Lys Val Glu Val Lys Glu Asp Ala Lys Pro Lys Glu Lys Thr Glu Val 
         915                920                925
Ala Lys Lys Glu Pro Asp Asp Ala Lys Ala Lys Glu Pro Ser Lys Pro 
     930                935                940
Ala Glu Lys Lys Glu Ala Ala Pro Glu Lys Lys Asp Thr Lys Glu Glu 
 945                950                955                960
Lys Ala Lys Lys Pro Glu Glu Lys Pro Lys Thr Glu Ala Lys Ala Lys 
                 965                970                975
Glu Asp Asp Lys Thr Leu Ser Lys Glu Pro Ser Lys Pro Lys Ala Glu 
             980                985                990
Lys Ala Glu Lys Ser Ser Ser Thr Asp Gln Lys Asp Ser Lys Pro Pro 
         995                1000                1005
Glu Lys Ala Thr Glu Asp Lys Ala Ala Lys Gly Lys 
     1010                1015                1020



<210> 4799
<211> 481
<212> DNA
<213> Rattus norvegicus
<308> AA818726
<400> 4799

ttttttttt  tttttttga  cgggatccc  ccagtccca  gggcccaaa  tggacccag  60
tcctaggca  cagatttat  ggttcacag  ccaaactga  ggcaagggt  aagggctca  120
ggacagacc  ggaggccca  agccctgca  ccctaccag  atccctgag  ccagcctgc  180
gctaccagg  gctgaagtc  ccaaagccc  gactgggcc  tttcttggc  gtggggata  240
ctgtgctgg  ggatggttc  tcctctgct  ctcgtttcg  ggctgcagg  ttgatgtac  300
tgcccaccc  ctggcggta  gtctggggg  cctggtttc  aggctgggg  tggttcgtc  360
tggccttgg  ctctggatc  acttggtgc  gtgtcttct  ccgttcctg  gcaatatgg  420
cgtcggcct  ctcataggg  tccacaaac  ctgtggtgg  acagatgcg  acttcttcc  480
t  481



<210> 4800
<211> 2060
<212> DNA
<213> Homo sapiens
<308> U37221
<400> 4800

aggagctct  caaggagtt  aaaggggac  agattctgg  agccaccat  aaggccccg  60
agaagaaga  agtggacaa  ctgaatgct  cccactatt  cacagggaa  gtcagcgct  120
ccttcacct  caccgcgat  gtcccggag  ccacacatg  agcagctgc  atcgacgag  180
atgtgctgc  ctaccagtt  gtgaagaag  agggctacg  gcggctgca  accaacaag  240
gcgacctca  cctggagct  cactgcgac  tgacaccaa  aacctgcga  aacttcatc  300
ggctttgca  gaagcatta  tacgatggc  ccatcttcc  cagatccat  cggaacttt  360
tgatccaag  gggcgaccc  acaggcaca  gcacgggtg  ggagtcata  tgggggaag  420
ccttcaaag  cgagttccg  cccaacctc  cgcacacgg  ccgcggcat  ctcagcatg  480
ccaactccg  gcccaacag  aacaggtct  aattcttca  cacgtttcg  tcctgtgcc  540
acctggaca  gaagcatac  atctttgga  gggttgttg  gggctttga  gtactgaca  600
ccatggaga  tgtggagag  gaccccaaa  ctgaccgcc  taaggagga  atccgcatt  660
atgccacta  agtgttcgt  gacccctat  aggaggccg  tgcccagat  gcgcaggag  720
ggaagacac  gctcaaggt  gccccggag  ccaaagtga  gagcagcca  ccccaggca  780
ggagccagg  cccccagac  ttccgccag  gcgtgggca  gtacatcaa  ccagcagcc  840
cgaagcgag  agcagagga  gagccctca  ccagtgcca  tgtccccat  tccaagaag  900
agcccagtc  gggttttgg  gacttcagc  cctggtagc  gcagcaact  gcaggctgt  960
cctctgccc  tccttttct  atcaatcac  gatgctgaa  ctgcaggcc  gagcccttt  1020
tctccctgg  tgctgggtg  cgcctcatc  gcatctctg  ctcacccca  ccactgcca  1080
aggctgcct  atgaccact  gaggtatgt  tgcccctcg  caccctgct  cacaccaat  1140
tgtggccct  catcatgct  agaacaaga  ctgcgccat  gctggctcc  tctcttctc  1200
agcccatcc  tctgcagcc  gtcatccct  tctgtgacc  ttggtcggg  ccctgggct  1260
tagagtgac  tttgacgcc  tccatccct  ccgccaggc  ctgtcctcc  caaggcctg  1320
tgcagccct  gcagtaact  gcttgtaag  ggctcagac  ccaagctgg  cctgcagag  1380
aggggcaca  taggacaca  tgactgccc  ggtgtccac  cacctgtag  cctctgagc  1440
agcgtccag  gtacaggtg  gggtggtgg  gatgaaggc  tgaccaggg  gtgagaagc  1500
ggtttggag  ggaccctgt  cccaccctg  cagacaccc  ggctggccc  gactgactg  1560
attctctgg  cacattcaa  tcccccatt  gtgggggca  agaagtagg  ccaggccat  1620
cttggctac  gagctcgaa  accccaaga  agccctctg  tctcagcgg  gccacagag  1680
gcctgggct  agccttctg  atcaggaca  ggcctcgtc  actgagggc  cgatttaaa  1740
atttgacat  agaagcttt  tttgtaaac  tcacacaga  aaggaccaa  ggctggcgg  1800
gtggccaga  gacagggga  gctgaaggc  ccgtgcttg  gctcggcag  cctgctcct  1860
gcagtgaag  caccatggg  gaccgtcca  cctcacccg  tggcctgca  agtgaggga  1920
gggcttcag  gccatctgc  cccagggca  gggacaggc  accaaggac  tttggcaaa  1980
gaaggttta  atttctgta  tttgtttgt  ttagagctt  atttgtagt  ttttagcta  2040
taaaaccat  tgaattttta  2060



<210> 4801
<211> 520
<212> PRT
<213> Homo sapiens
<308> NP_055152
<400> 4801

Met Gly Lys Arg Gln His Gln Lys Asp Lys Met Tyr Ile Thr Cys Ala 
  1               5                  10                  15
Glu Tyr Thr His Phe Tyr Gly Gly Lys Lys Pro Asp Leu Pro Gln Thr 
             20                  25                  30
Asn Phe Arg Arg Leu Pro Phe Asp His Cys Ser Leu Ser Leu Gln Pro 
         35                  40                  45
Phe Val Tyr Pro Val Cys Thr Pro Asp Gly Ile Val Phe Asp Leu Leu 
     50                  55                  60
Asn Ile Val Pro Trp Leu Lys Lys Tyr Gly Thr Asn Pro Ser Asn Gly 
 65                  70                  75                  80
Glu Lys Leu Asp Gly Arg Ser Leu Ile Lys Leu Asn Phe Ser Lys Asn 
                 85                  90                  95
Ser Glu Gly Lys Tyr His Cys Pro Val Leu Phe Thr Val Phe Thr Asn 
             100                105                110
Asn Thr His Ile Val Ala Val Arg Thr Thr Gly Asn Val Tyr Ala Tyr 
         115                120                125
Glu Ala Val Glu Gln Leu Asn Ile Lys Ala Lys Asn Phe Arg Asp Leu 
     130                135                140
Leu Thr Asp Glu Pro Phe Ser Arg Gln Asp Ile Ile Thr Leu Gln Asp 
 145                150                155                160
Pro Thr Asn Leu Asp Lys Phe Asn Val Ser Asn Phe Tyr His Val Lys 
                 165                170                175
Asn Asn Met Lys Ile Ile Asp Pro Asp Glu Glu Lys Ala Lys Gln Asp 
             180                185                190
Pro Ser Tyr Tyr Leu Lys Asn Thr Asn Ala Glu Thr Arg Glu Thr Leu 
         195                200                205
Gln Glu Leu Tyr Lys Glu Phe Lys Gly Asp Glu Ile Leu Ala Ala Thr 
     210                215                220
Met Lys Ala Pro Glu Lys Lys Lys Val Asp Lys Leu Asn Ala Ala His 
 225                230                235                240
Tyr Ser Thr Gly Lys Val Ser Ala Ser Phe Thr Ser Thr Ala Met Val 
                 245                250                255
Pro Glu Thr Thr His Glu Ala Ala Ala Ile Asp Glu Asp Val Leu Arg 
             260                265                270
Tyr Gln Phe Val Lys Lys Lys Gly Tyr Val Arg Leu His Thr Asn Lys 
         275                280                285
Gly Asp Leu Asn Leu Glu Leu His Cys Asp Leu Thr Pro Lys Thr Cys 
     290                295                300
Glu Asn Phe Ile Arg Leu Cys Lys Lys His Tyr Tyr Asp Gly Thr Ile 
 305                310                315                320
Phe His Arg Ser Ile Arg Asn Phe Val Ile Gln Gly Gly Asp Pro Thr 
                 325                330                335
Gly Thr Gly Thr Gly Gly Glu Ser Tyr Trp Gly Lys Pro Phe Lys Asp 
             340                345                350
Glu Phe Arg Pro Asn Leu Ser His Thr Gly Arg Gly Ile Leu Ser Met 
         355                360                365
Ala Asn Ser Gly Pro Asn Ser Asn Arg Ser Gln Phe Phe Ile Thr Phe 
     370                375                380
Arg Ser Cys Ala Tyr Leu Asp Lys Lys His Thr Ile Phe Gly Arg Val 
 385                390                395                400
Val Gly Gly Phe Asp Val Leu Thr Ala Met Glu Asn Val Glu Ser Asp 
                 405                410                415
Pro Lys Thr Asp Arg Pro Lys Glu Glu Ile Arg Ile Asp Ala Thr Thr 
             420                425                430
Val Phe Val Asp Pro Tyr Glu Glu Ala Asp Ala Gln Ile Ala Gln Glu 
         435                440                445
Arg Lys Thr Gln Leu Lys Val Ala Pro Glu Thr Lys Val Lys Ser Ser 
     450                455                460
Gln Pro Gln Ala Gly Ser Gln Gly Pro Gln Thr Phe Arg Gln Gly Val 
 465                470                475                480
Gly Lys Tyr Ile Asn Pro Ala Ala Thr Lys Arg Ala Ala Glu Glu Glu 
                 485                490                495
Pro Ser Thr Ser Ala Thr Val Pro Met Ser Lys Lys Lys Pro Ser Arg 
             500                505                510
Gly Phe Gly Asp Phe Ser Ser Trp 
         515                520



<210> 4802
<211> 469
<212> DNA
<213> Rattus norvegicus
<308> AA818843
<400> 4802

ttttttttt  tttttttca  ataggaatt  tatggataa  gtctagtag  cagtgcgta  60
agaagtagg  aacacctta  tcattaatt  tacagataa  gtcgagtag  cagtgcgta  120
tcattaatt  gataatgtc  agtagacag  gcgtacaca  gttgggaaa  ctcgttcat  180
aattttgtc  cttatctag  tcagtaaaa  gctcacaag  aaaataacc  cctaaggca  240
aaacttcat  cacaacttc  tgagagcag  cagatcaat  ctgatcaac  tccctgctt  300
agactgaat  attcatcct  aaacaggtc  ttttgtgag  tggacatcc  tgttacgct  360
gaaaagctg  agcacaaat  caaccgtag  gttggaatc  tcaacagcc  agacggaag  420
ctgcttgta  tttttagta  ccaaaacct  tttgccaca  atcgcacag  469



<210> 4803
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> NP_063972
<400> 4803

Met Val Cys Glu Lys Cys Glu Lys Lys Leu Gly Arg Val Ile Thr Pro 
  1               5                  10                  15
Asp Thr Trp Lys Asp Gly Ala Arg Asn Thr Thr Glu Ser Gly Gly Arg 
             20                  25                  30
Lys Leu Asn Glu Asn Lys Ala Leu Thr Ser Lys Lys Ala Arg Phe Asp 
         35                  40                  45
Pro Tyr Gly Lys Asn Lys Phe Ser Thr Cys Arg Ile Cys Lys Ser Ser 
     50                  55                  60
Val His Gln Pro Gly Ser His Tyr Cys Gln Gly Cys Ala Tyr Lys Lys 
 65                  70                  75                  80
Gly Ile Cys Ala Met Cys Gly Lys Lys Val Leu Asp Thr Lys Asn Tyr 
                 85                  90                  95
Lys Gln Thr Ser Val 
             100



<210> 4804
<211> 628
<212> DNA
<213> Rattus norvegicus
<308> AA818858
<400> 4804

ttttttttt  tttttttaa  acttctcat  tagttttta  tcataatca  aaacttaac  60
ttgcaatcc  gctagactt  aaggggaat  aggaaaata  ggaacccaa  gaacttcag  120
gagagcaga  attacaggg  attgcgagc  gatggggtg  gggtgctct  ctgagctac  180
gaaggaatg  tttgatggg  aaaatgccc  caagtcaaa  aaattagag  tgtccacag  240
cggagatgg  gatcttctt  ctggtcttg  cattcctgg  cccaaaacg  tccatggct  300
ccacaatgc  catgccttc  ttcaccttc  caaagacca  atgcttgcc  tccagccac  360
cagtcttgg  agtgcagat  aaaaactgg  aaccatttg  gtttggtcc  gcatttgcc  420
tggacaaga  gccaggacc  gtatgcttc  ggatgaagt  ctcatcctc  aatttctct  480
cgtagatgg  cttgccacc  gtgccatta  ggcgtgtga  gtcaccacc  tggcacatg  540
atcctggaa  aattctgtg  aaggaggaa  ccttatagc  aaatccttt  tccccagtg  600
tcagagcac  aaagttttc  gctgtctt  628



<210> 4805
<211> 163
<212> PRT
<213> Rattus norvegicus
<308> P10111
<400> 4805

Val Asn Pro Thr Val Phe Phe Asp Ile Thr Ala Asp Gly Glu Pro Leu 
  1               5                  10                  15
Gly Arg Val Cys Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala 
             20                  25                  30
Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys 
         35                  40                  45
Gly Ser Ser Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly 
     50                  55                  60
Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu 
 65                  70                  75                  80
Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile 
                 85                  90                  95
Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe 
             100                105                110
Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val Phe 
         115                120                125
Gly Lys Val Lys Glu Gly Met Ser Ile Val Glu Ala Met Glu Arg Phe 
     130                135                140
Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ser Asp Cys 
 145                150                155                160
Gly Gln Leu 
                 165



<210> 4806
<211> 382
<212> DNA
<213> Homo sapiens
<308> AA071425
<400> 4806

agaattatt  cagggttta  gtgtcaggg  ggtgacttc  cacgccata  tggcactgg  60
ggcaagtcc  tctatgggg  gaaatttga  gatgagaac  tcatcctaa  gcatacggg  120
cctggcatc  tgtccatgg  aaatgctgg  cccaacaca  atggttccc  gtttttcat  180
tgcactgcc  agactgagt  gttggatgg  aagcatgtg  tgtttggca  agtgaaaag  240
aggcatgaa  attgtggaa  gccatggaa  cgctttggg  ccaggaatg  caaagacca  300
caaagaaag  tcaccattg  tgactgtgg  caactcgaa  aagtttgac  tgtgtttta  360
ctttaacca  cagatcatt  cc  382



<210> 4807
<211> 164
<212> PRT
<213> Homo sapiens
<308> P05092
<400> 4807

Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro Leu 
  1               5                  10                  15
Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala 
             20                  25                  30
Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys 
         35                  40                  45
Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly 
     50                  55                  60
Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu 
 65                  70                  75                  80
Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile 
                 85                  90                  95
Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe 
             100                105                110
Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val Phe 
         115                120                125
Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg Phe 
     130                135                140
Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys 
 145                150                155                160
Gly Gln Leu Glu 
                 165



<210> 4808
<211> 561
<212> DNA
<213> Rattus norvegicus
<308> AA819338
<400> 4808

ttttttttt  tttttttga  tgtactcat  tcaaatagt  actgtttat  gaaagaagc  60
atggagggc  gaggttgct  ccctcaggc  tggatgtgg  tctttgcac  gaaagctag  120
tagtagatc  ctatgccaa  tgctgcagc  agcaccccg  ggagaccca  ggcccattc  180
aggtacccc  atggtccac  ctgactgtg  acagtggtg  gatgatgga  acgtcttca  240
tatttcttt  agccttcct  aggaggctg  aggactctt  atcgaagaa  ctgacctca  300
aggtgcctg  atgggcgct  ttgtgctcc  ggctccagg  cacctgata  cgacccaca  360
cctggccgc  ggttacagg  aattgtttt  cactaacgt  ggcataaag  gccatattc  420
ggaccctgt  tttgcaggt  agtgagatc  ccacgatga  tacagtctc  gtagaaatg  480
cggcatctg  agttgtata  taagaaggg  tgatctggg  ttccaggca  gcctctgag  540
agcaagata  gccggacag  a  561



<210> 4809
<211> 173
<212> PRT
<213> Rattus norvegicus
<308> Q07984
<400> 4809

Met Ala Ala Met Ala Ser Phe Gly Ala Leu Ala Leu Leu Leu Leu Ser 
  1               5                  10                  15
Gly Leu Ser Cys Cys Ser Ala Glu Ala Cys Leu Glu Pro Gln Ile Thr 
             20                  25                  30
Pro Ser Tyr Tyr Thr Thr Ser Asp Ala Val Ile Ser Thr Glu Thr Val 
         35                  40                  45
Phe Ile Val Glu Ile Ser Leu Thr Cys Lys Asn Arg Val Gln Asn Met 
     50                  55                  60
Ala Leu Tyr Ala Asp Val Ser Gly Lys Gln Phe Pro Val Thr Arg Gly 
 65                  70                  75                  80
Gln Asp Val Gly Arg Tyr Gln Val Ser Trp Ser Leu Glu His Lys Ser 
                 85                  90                  95
Ala His Ala Gly Thr Tyr Glu Val Arg Phe Phe Asp Glu Glu Ser Tyr 
             100                105                110
Ser Leu Leu Arg Lys Ala Gln Arg Asn Asn Glu Asp Val Ser Ile Ile 
         115                120                125
Pro Pro Leu Phe Thr Val Ser Val Asp His Arg Gly Thr Trp Asn Gly 
     130                135                140
Pro Trp Val Ser Thr Glu Val Leu Ala Ala Ala Ile Gly Ile Val Ile 
 145                150                155                160
Tyr Tyr Leu Ala Phe Ser Ala Lys Ser His Ile Gln Ala 
                 165                170



<210> 4810
<211> 642
<212> DNA
<213> Homo sapiens
<308> Z69043
<400> 4810

tcgtgttca  gggagctcg  tttcttttc  tctaggcag  gaagaggcg  tggcggcga  60
ggcatctct  ggcgccctg  cgctgctcc  gctgtccag  ctctcccgc  gctcagccg  120
ggcctgcct  gagccccag  tcacccctt  ctactacac  acttctgac  ctgtcattt  180
cactgagac  gtcttcatt  tggagatct  cctgacatg  aagaacagg  tccagaaca  240
ggctctcta  gctgacgtc  gtggaaaac  attccctgt  actcgaggc  aggatgtgg  300
gcgttatca  gtgtcctgg  gcctggacc  caagagcgc  cacgcaggc  cctatgagg  360
tagattctt  gacgaggag  cctacagcc  cctcaggaa  gctcagagg  ataacgagg  420
catttccat  atcccgcct  tgtttacag  cagcgtgga  catcggggc  cttggaacg  480
gccctgggt  tccactgag  tgctggctg  ggcgatcgg  cttgtgatc  actacttgg  540
cttcagtgc  aagagccac  tccaggcct  agggcggca  cccagccct  cccttgctt  600
cttcaataa  catcacagg  cctgggact  cacaggaaa  aa  642



<210> 4811
<211> 173
<212> PRT
<213> Homo sapiens
<308> P51571
<400> 4811

Met Ala Ala Met Ala Ser Leu Gly Ala Leu Ala Leu Leu Leu Leu Ser 
  1               5                  10                  15
Ser Leu Ser Arg Cys Ser Ala Glu Ala Cys Leu Glu Pro Gln Ile Thr 
             20                  25                  30
Pro Ser Tyr Tyr Thr Thr Ser Asp Ala Val Ile Ser Thr Glu Thr Val 
         35                  40                  45
Phe Ile Val Glu Ile Ser Leu Thr Cys Lys Asn Arg Val Gln Asn Met 
     50                  55                  60
Ala Leu Tyr Ala Asp Val Gly Gly Lys Gln Phe Pro Val Thr Arg Gly 
 65                  70                  75                  80
Gln Asp Val Gly Arg Tyr Gln Val Ser Trp Ser Leu Asp His Lys Ser 
                 85                  90                  95
Ala His Ala Gly Thr Tyr Glu Val Arg Phe Phe Asp Glu Glu Ser Tyr 
             100                105                110
Ser Leu Leu Arg Lys Ala Gln Arg Asn Asn Glu Asp Ile Ser Ile Ile 
         115                120                125
Pro Pro Leu Phe Thr Val Ser Val Asp His Arg Gly Thr Trp Asn Gly 
     130                135                140
Pro Trp Val Ser Thr Glu Val Leu Ala Ala Ala Ile Gly Leu Val Ile 
 145                150                155                160
Tyr Tyr Leu Ala Phe Ser Ala Lys Ser His Ile Gln Ala 
                 165                170



<210> 4812
<211> 561
<212> DNA
<213> Rattus norvegicus
<308> AA819338
<400> 4812

ttttttttt  tttttttga  tgtactcat  tcaaatagt  actgtttat  gaaagaagc  60
atggagggc  gaggttgct  ccctcaggc  tggatgtgg  tctttgcac  gaaagctag  120
tagtagatc  ctatgccaa  tgctgcagc  agcaccccg  ggagaccca  ggcccattc  180
aggtacccc  atggtccac  ctgactgtg  acagtggtg  gatgatgga  acgtcttca  240
tatttcttt  agccttcct  aggaggctg  aggactctt  atcgaagaa  ctgacctca  300
aggtgcctg  atgggcgct  ttgtgctcc  ggctccagg  cacctgata  cgacccaca  360
cctggccgc  ggttacagg  aattgtttt  cactaacgt  ggcataaag  gccatattc  420
ggaccctgt  tttgcaggt  agtgagatc  ccacgatga  tacagtctc  gtagaaatg  480
cggcatctg  agttgtata  taagaaggg  tgatctggg  ttccaggca  gcctctgag  540
agcaagata  gccggacag  a  561



<210> 4813
<211> 173
<212> PRT
<213> Rattus norvegicus
<308> Q07984
<400> 4813

Met Ala Ala Met Ala Ser Phe Gly Ala Leu Ala Leu Leu Leu Leu Ser 
  1               5                  10                  15
Gly Leu Ser Cys Cys Ser Ala Glu Ala Cys Leu Glu Pro Gln Ile Thr 
             20                  25                  30
Pro Ser Tyr Tyr Thr Thr Ser Asp Ala Val Ile Ser Thr Glu Thr Val 
         35                  40                  45
Phe Ile Val Glu Ile Ser Leu Thr Cys Lys Asn Arg Val Gln Asn Met 
     50                  55                  60
Ala Leu Tyr Ala Asp Val Ser Gly Lys Gln Phe Pro Val Thr Arg Gly 
 65                  70                  75                  80
Gln Asp Val Gly Arg Tyr Gln Val Ser Trp Ser Leu Glu His Lys Ser 
                 85                  90                  95
Ala His Ala Gly Thr Tyr Glu Val Arg Phe Phe Asp Glu Glu Ser Tyr 
             100                105                110
Ser Leu Leu Arg Lys Ala Gln Arg Asn Asn Glu Asp Val Ser Ile Ile 
         115                120                125
Pro Pro Leu Phe Thr Val Ser Val Asp His Arg Gly Thr Trp Asn Gly 
     130                135                140
Pro Trp Val Ser Thr Glu Val Leu Ala Ala Ala Ile Gly Ile Val Ile 
 145                150                155                160
Tyr Tyr Leu Ala Phe Ser Ala Lys Ser His Ile Gln Ala 
                 165                170



<210> 4814
<211> 642
<212> DNA
<213> Homo sapiens
<308> Z69043
<400> 4814

tcgtgttca  gggagctcg  tttcttttc  tctaggcag  gaagaggcg  tggcggcga  60
ggcatctct  ggcgccctg  cgctgctcc  gctgtccag  ctctcccgc  gctcagccg  120
ggcctgcct  gagccccag  tcacccctt  ctactacac  acttctgac  ctgtcattt  180
cactgagac  gtcttcatt  tggagatct  cctgacatg  aagaacagg  tccagaaca  240
ggctctcta  gctgacgtc  gtggaaaac  attccctgt  actcgaggc  aggatgtgg  300
gcgttatca  gtgtcctgg  gcctggacc  caagagcgc  cacgcaggc  cctatgagg  360
tagattctt  gacgaggag  cctacagcc  cctcaggaa  gctcagagg  ataacgagg  420
catttccat  atcccgcct  tgtttacag  cagcgtgga  catcggggc  cttggaacg  480
gccctgggt  tccactgag  tgctggctg  ggcgatcgg  cttgtgatc  actacttgg  540
cttcagtgc  aagagccac  tccaggcct  agggcggca  cccagccct  cccttgctt  600
cttcaataa  catcacagg  cctgggact  cacaggaaa  aa  642



<210> 4815
<211> 173
<212> PRT
<213> Homo sapiens
<308> P51571
<400> 4815

Met Ala Ala Met Ala Ser Leu Gly Ala Leu Ala Leu Leu Leu Leu Ser 
  1               5                  10                  15
Ser Leu Ser Arg Cys Ser Ala Glu Ala Cys Leu Glu Pro Gln Ile Thr 
             20                  25                  30
Pro Ser Tyr Tyr Thr Thr Ser Asp Ala Val Ile Ser Thr Glu Thr Val 
         35                  40                  45
Phe Ile Val Glu Ile Ser Leu Thr Cys Lys Asn Arg Val Gln Asn Met 
     50                  55                  60
Ala Leu Tyr Ala Asp Val Gly Gly Lys Gln Phe Pro Val Thr Arg Gly 
 65                  70                  75                  80
Gln Asp Val Gly Arg Tyr Gln Val Ser Trp Ser Leu Asp His Lys Ser 
                 85                  90                  95
Ala His Ala Gly Thr Tyr Glu Val Arg Phe Phe Asp Glu Glu Ser Tyr 
             100                105                110
Ser Leu Leu Arg Lys Ala Gln Arg Asn Asn Glu Asp Ile Ser Ile Ile 
         115                120                125
Pro Pro Leu Phe Thr Val Ser Val Asp His Arg Gly Thr Trp Asn Gly 
     130                135                140
Pro Trp Val Ser Thr Glu Val Leu Ala Ala Ala Ile Gly Leu Val Ile 
 145                150                155                160
Tyr Tyr Leu Ala Phe Ser Ala Lys Ser His Ile Gln Ala 
                 165                170



<210> 4816
<211> 561
<212> DNA
<213> Rattus norvegicus
<308> AA819338
<400> 4816

ttttttttt  tttttttga  tgtactcat  tcaaatagt  actgtttat  gaaagaagc  60
atggagggc  gaggttgct  ccctcaggc  tggatgtgg  tctttgcac  gaaagctag  120
tagtagatc  ctatgccaa  tgctgcagc  agcaccccg  ggagaccca  ggcccattc  180
aggtacccc  atggtccac  ctgactgtg  acagtggtg  gatgatgga  acgtcttca  240
tatttcttt  agccttcct  aggaggctg  aggactctt  atcgaagaa  ctgacctca  300
aggtgcctg  atgggcgct  ttgtgctcc  ggctccagg  cacctgata  cgacccaca  360
cctggccgc  ggttacagg  aattgtttt  cactaacgt  ggcataaag  gccatattc  420
ggaccctgt  tttgcaggt  agtgagatc  ccacgatga  tacagtctc  gtagaaatg  480
cggcatctg  agttgtata  taagaaggg  tgatctggg  ttccaggca  gcctctgag  540
agcaagata  gccggacag  a  561



<210> 4817
<211> 173
<212> PRT
<213> Rattus norvegicus
<308> Q07984
<400> 4817

Met Ala Ala Met Ala Ser Phe Gly Ala Leu Ala Leu Leu Leu Leu Ser 
  1               5                  10                  15
Gly Leu Ser Cys Cys Ser Ala Glu Ala Cys Leu Glu Pro Gln Ile Thr 
             20                  25                  30
Pro Ser Tyr Tyr Thr Thr Ser Asp Ala Val Ile Ser Thr Glu Thr Val 
         35                  40                  45
Phe Ile Val Glu Ile Ser Leu Thr Cys Lys Asn Arg Val Gln Asn Met 
     50                  55                  60
Ala Leu Tyr Ala Asp Val Ser Gly Lys Gln Phe Pro Val Thr Arg Gly 
 65                  70                  75                  80
Gln Asp Val Gly Arg Tyr Gln Val Ser Trp Ser Leu Glu His Lys Ser 
                 85                  90                  95
Ala His Ala Gly Thr Tyr Glu Val Arg Phe Phe Asp Glu Glu Ser Tyr 
             100                105                110
Ser Leu Leu Arg Lys Ala Gln Arg Asn Asn Glu Asp Val Ser Ile Ile 
         115                120                125
Pro Pro Leu Phe Thr Val Ser Val Asp His Arg Gly Thr Trp Asn Gly 
     130                135                140
Pro Trp Val Ser Thr Glu Val Leu Ala Ala Ala Ile Gly Ile Val Ile 
 145                150                155                160
Tyr Tyr Leu Ala Phe Ser Ala Lys Ser His Ile Gln Ala 
                 165                170



<210> 4818
<211> 642
<212> DNA
<213> Homo sapiens
<308> Z69043
<400> 4818

tcgtgttca  gggagctcg  tttcttttc  tctaggcag  gaagaggcg  tggcggcga  60
ggcatctct  ggcgccctg  cgctgctcc  gctgtccag  ctctcccgc  gctcagccg  120
ggcctgcct  gagccccag  tcacccctt  ctactacac  acttctgac  ctgtcattt  180
cactgagac  gtcttcatt  tggagatct  cctgacatg  aagaacagg  tccagaaca  240
ggctctcta  gctgacgtc  gtggaaaac  attccctgt  actcgaggc  aggatgtgg  300
gcgttatca  gtgtcctgg  gcctggacc  caagagcgc  cacgcaggc  cctatgagg  360
tagattctt  gacgaggag  cctacagcc  cctcaggaa  gctcagagg  ataacgagg  420
catttccat  atcccgcct  tgtttacag  cagcgtgga  catcggggc  cttggaacg  480
gccctgggt  tccactgag  tgctggctg  ggcgatcgg  cttgtgatc  actacttgg  540
cttcagtgc  aagagccac  tccaggcct  agggcggca  cccagccct  cccttgctt  600
cttcaataa  catcacagg  cctgggact  cacaggaaa  aa  642



<210> 4819
<211> 173
<212> PRT
<213> Homo sapiens
<308> P51571
<400> 4819

Met Ala Ala Met Ala Ser Leu Gly Ala Leu Ala Leu Leu Leu Leu Ser 
  1               5                  10                  15
Ser Leu Ser Arg Cys Ser Ala Glu Ala Cys Leu Glu Pro Gln Ile Thr 
             20                  25                  30
Pro Ser Tyr Tyr Thr Thr Ser Asp Ala Val Ile Ser Thr Glu Thr Val 
         35                  40                  45
Phe Ile Val Glu Ile Ser Leu Thr Cys Lys Asn Arg Val Gln Asn Met 
     50                  55                  60
Ala Leu Tyr Ala Asp Val Gly Gly Lys Gln Phe Pro Val Thr Arg Gly 
 65                  70                  75                  80
Gln Asp Val Gly Arg Tyr Gln Val Ser Trp Ser Leu Asp His Lys Ser 
                 85                  90                  95
Ala His Ala Gly Thr Tyr Glu Val Arg Phe Phe Asp Glu Glu Ser Tyr 
             100                105                110
Ser Leu Leu Arg Lys Ala Gln Arg Asn Asn Glu Asp Ile Ser Ile Ile 
         115                120                125
Pro Pro Leu Phe Thr Val Ser Val Asp His Arg Gly Thr Trp Asn Gly 
     130                135                140
Pro Trp Val Ser Thr Glu Val Leu Ala Ala Ala Ile Gly Leu Val Ile 
 145                150                155                160
Tyr Tyr Leu Ala Phe Ser Ala Lys Ser His Ile Gln Ala 
                 165                170



<210> 4820
<211> 561
<212> DNA
<213> Rattus norvegicus
<308> AA819338
<400> 4820

ttttttttt  tttttttga  tgtactcat  tcaaatagt  actgtttat  gaaagaagc  60
atggagggc  gaggttgct  ccctcaggc  tggatgtgg  tctttgcac  gaaagctag  120
tagtagatc  ctatgccaa  tgctgcagc  agcaccccg  ggagaccca  ggcccattc  180
aggtacccc  atggtccac  ctgactgtg  acagtggtg  gatgatgga  acgtcttca  240
tatttcttt  agccttcct  aggaggctg  aggactctt  atcgaagaa  ctgacctca  300
aggtgcctg  atgggcgct  ttgtgctcc  ggctccagg  cacctgata  cgacccaca  360
cctggccgc  ggttacagg  aattgtttt  cactaacgt  ggcataaag  gccatattc  420
ggaccctgt  tttgcaggt  agtgagatc  ccacgatga  tacagtctc  gtagaaatg  480
cggcatctg  agttgtata  taagaaggg  tgatctggg  ttccaggca  gcctctgag  540
agcaagata  gccggacag  a  561



<210> 4821
<211> 173
<212> PRT
<213> Rattus norvegicus
<308> Q07984
<400> 4821

Met Ala Ala Met Ala Ser Phe Gly Ala Leu Ala Leu Leu Leu Leu Ser 
  1               5                  10                  15
Gly Leu Ser Cys Cys Ser Ala Glu Ala Cys Leu Glu Pro Gln Ile Thr 
             20                  25                  30
Pro Ser Tyr Tyr Thr Thr Ser Asp Ala Val Ile Ser Thr Glu Thr Val 
         35                  40                  45
Phe Ile Val Glu Ile Ser Leu Thr Cys Lys Asn Arg Val Gln Asn Met 
     50                  55                  60
Ala Leu Tyr Ala Asp Val Ser Gly Lys Gln Phe Pro Val Thr Arg Gly 
 65                  70                  75                  80
Gln Asp Val Gly Arg Tyr Gln Val Ser Trp Ser Leu Glu His Lys Ser 
                 85                  90                  95
Ala His Ala Gly Thr Tyr Glu Val Arg Phe Phe Asp Glu Glu Ser Tyr 
             100                105                110
Ser Leu Leu Arg Lys Ala Gln Arg Asn Asn Glu Asp Val Ser Ile Ile 
         115                120                125
Pro Pro Leu Phe Thr Val Ser Val Asp His Arg Gly Thr Trp Asn Gly 
     130                135                140
Pro Trp Val Ser Thr Glu Val Leu Ala Ala Ala Ile Gly Ile Val Ile 
 145                150                155                160
Tyr Tyr Leu Ala Phe Ser Ala Lys Ser His Ile Gln Ala 
                 165                170



<210> 4822
<211> 642
<212> DNA
<213> Homo sapiens
<308> Z69043
<400> 4822

tcgtgttca  gggagctcg  tttcttttc  tctaggcag  gaagaggcg  tggcggcga  60
ggcatctct  ggcgccctg  cgctgctcc  gctgtccag  ctctcccgc  gctcagccg  120
ggcctgcct  gagccccag  tcacccctt  ctactacac  acttctgac  ctgtcattt  180
cactgagac  gtcttcatt  tggagatct  cctgacatg  aagaacagg  tccagaaca  240
ggctctcta  gctgacgtc  gtggaaaac  attccctgt  actcgaggc  aggatgtgg  300
gcgttatca  gtgtcctgg  gcctggacc  caagagcgc  cacgcaggc  cctatgagg  360
tagattctt  gacgaggag  cctacagcc  cctcaggaa  gctcagagg  ataacgagg  420
catttccat  atcccgcct  tgtttacag  cagcgtgga  catcggggc  cttggaacg  480
gccctgggt  tccactgag  tgctggctg  ggcgatcgg  cttgtgatc  actacttgg  540
cttcagtgc  aagagccac  tccaggcct  agggcggca  cccagccct  cccttgctt  600
cttcaataa  catcacagg  cctgggact  cacaggaaa  aa  642



<210> 4823
<211> 173
<212> PRT
<213> Homo sapiens
<308> P51571
<400> 4823

Met Ala Ala Met Ala Ser Leu Gly Ala Leu Ala Leu Leu Leu Leu Ser 
  1               5                  10                  15
Ser Leu Ser Arg Cys Ser Ala Glu Ala Cys Leu Glu Pro Gln Ile Thr 
             20                  25                  30
Pro Ser Tyr Tyr Thr Thr Ser Asp Ala Val Ile Ser Thr Glu Thr Val 
         35                  40                  45
Phe Ile Val Glu Ile Ser Leu Thr Cys Lys Asn Arg Val Gln Asn Met 
     50                  55                  60
Ala Leu Tyr Ala Asp Val Gly Gly Lys Gln Phe Pro Val Thr Arg Gly 
 65                  70                  75                  80
Gln Asp Val Gly Arg Tyr Gln Val Ser Trp Ser Leu Asp His Lys Ser 
                 85                  90                  95
Ala His Ala Gly Thr Tyr Glu Val Arg Phe Phe Asp Glu Glu Ser Tyr 
             100                105                110
Ser Leu Leu Arg Lys Ala Gln Arg Asn Asn Glu Asp Ile Ser Ile Ile 
         115                120                125
Pro Pro Leu Phe Thr Val Ser Val Asp His Arg Gly Thr Trp Asn Gly 
     130                135                140
Pro Trp Val Ser Thr Glu Val Leu Ala Ala Ala Ile Gly Leu Val Ile 
 145                150                155                160
Tyr Tyr Leu Ala Phe Ser Ala Lys Ser His Ile Gln Ala 
                 165                170



<210> 4824
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AA819500
<400> 4824

ttttttttt  tttttttac  ggtggtttg  tcctttatt  ctattattc  tacaaaaga  60
catcgatct  aacagttct  ggtcagttg  tgcatcaca  ttgcgcaga  gctcatcag  120
tgcaggtgc  catctgcac  atctgctaa  cacttatcc  cctcagcaa  tttttctgt  180
atgatggac  tctgtttat  agacagatt  tcatcttct  tgattgaat  atgaagttg  240
ttgacaagc  gagtggctg  atgcccttc  tctattagg  tcttcagca  ggcttctag  300
ttgtcaaaa  agccgctgt  acatgcagt  actattccc  caatggttg  agctggtat  360
accccagca  tgtctgtga  cacatcttc  gagatttcc  ttccacctg  tagtcgagt  420
gcactttga  gaaatgtaa  tgctttccg  aaatctcct  ctgatattc  aacaagata  480
gctatttcc  catcgccaa  tttgacatt  tccttctca  caatatcca  taatcgctt  540
t  541



<210> 4825
<211> 364
<212> PRT
<213> Rattus norvegicus
<308> AAH03335
<400> 4825

Met Gln Ala Phe Leu Lys Gly Thr Ser Val Ser Ala Lys Ala Gln Leu 
  1               5                  10                  15
Thr Lys Asp Arg Gly Thr Pro Ala Thr Ala Gly Ser Ser Gly Glu Thr 
             20                  25                  30
Lys Lys Val Lys Pro Val Pro Trp Val Glu Lys Tyr Arg Pro Lys Cys 
         35                  40                  45
Val Asp Glu Val Ala Phe Gln Asp Glu Val Val Ala Val Leu Arg Lys 
     50                  55                  60
Ser Leu Glu Gly Ala Asp Leu Pro Asn Leu Leu Phe Tyr Gly Pro Pro 
 65                  70                  75                  80
Gly Thr Gly Lys Thr Ser Thr Ile Leu Ala Ala Ala Arg Glu Leu Phe 
                 85                  90                  95
Gly Pro Glu Leu Phe Arg Leu Arg Val Leu Glu Leu Asn Ala Ser Asp 
             100                105                110
Glu Arg Gly Ile Gln Val Val Arg Glu Lys Val Lys Asn Phe Ala Gln 
         115                120                125
Leu Thr Val Ser Gly Ser Arg Ser Asp Gly Lys Pro Cys Pro Pro Phe 
     130                135                140
Lys Ile Val Ile Leu Asp Glu Ala Asp Ser Met Thr Ser Ala Ala Gln 
 145                150                155                160
Ala Ala Leu Arg Arg Thr Met Glu Lys Glu Ser Lys Thr Thr Arg Phe 
                 165                170                175
Cys Leu Ile Cys Asn Tyr Val Ser Arg Ile Ile Glu Pro Leu Thr Ser 
             180                185                190
Arg Cys Ser Lys Phe Arg Phe Lys Pro Leu Ser Asp Lys Ile Gln Gln 
         195                200                205
Glu Arg Leu Leu Asp Ile Ala Glu Lys Glu Asn Val Lys Ile Gly Asn 
     210                215                220
Glu Glu Ile Ala Tyr Leu Val Lys Ile Ser Glu Gly Asp Leu Arg Lys 
 225                230                235                240
Ala Ile Thr Phe Leu Gln Ser Ala Thr Arg Leu Thr Gly Gly Lys Glu 
                 245                250                255
Val Ser Glu Asp Val Ile Thr Asp Ile Ala Gly Val Ile Pro Ala Ala 
             260                265                270
Thr Ile Asp Gly Ile Phe Thr Ala Cys His Ser Gly Ser Phe Asp Lys 
         275                280                285
Leu Glu Ala Val Val Lys Asn Leu Ile Asp Glu Gly His Ala Ala Thr 
     290                295                300
Gln Leu Val Asn Gln Leu His Asp Ala Ile Ile Glu Asn Glu Asn Leu 
 305                310                315                320
Ser Asp Lys His Lys Ser Ile Ile Thr Glu Lys Leu Ala Glu Val Asp 
                 325                330                335
Lys Cys Leu Ala Asp Gly Ala Asp Glu His Leu Gln Leu Met Ser Leu 
             340                345                350
Cys Ala Thr Val Met Gln Gln Leu Thr Gln Asn Cys 
         355                360



<210> 4826
<211> 1446
<212> DNA
<213> Homo sapiens
<308> M87339
<400> 4826

ctgccattt  ggacaagct  gatgatgat  gtttgatag  tccaggggt  cgtgtatag  60
agatgatga  tctgcttca  ccagaatca  aatcttaaa  ggcgggaac  gaggcgact  120
tggggacat  agtgatcgt  agtctcctg  gcccgttat  ctcagatta  gtgacggag  180
taagacttc  agaccatct  gtccttttt  tatcgcgga  acctgagga  cgagccggc  240
gcggtgacc  gcacgagaa  ccaggctaa  tgggtgaag  accatgcaa  catttctta  300
aggtacatc  atcagtact  aacccccgc  gaccaagga  cgaggagta  ctgccagtg  360
gggaagtag  ggagagaac  agaaagcca  acccgttcc  tgggtggaa  aatatcgcc  420
aaaatgtgt  gatgaagtt  ctttccagg  agaagtggt  gcagtgctg  aaaaatctt  480
agaaggagc  gatcttcct  atctcttgt  ttacggacc  cctggaact  gaaaaacat  540
cactatttt  gcagcagct  gagaactct  tgggcctga  cttttccga  taagagttc  600
tgagttaaa  gcatctgat  aacgtggaa  acaagtagt  cgagagaaa  tgaaaaatt  660
tgctcaatt  actgtgtca  gaagtcgct  agatgggaa  ccgtgtccg  cttttaaga  720
tgtgattct  gatgaagca  attctatga  ctcagctgc  caggcagct  taagacgta  780
catggagaa  gagtcgaaa  ccacccgat  ctgtcttat  tgtaactat  tcagtcgaa  840
aattgaacc  ctgacctct  gatgttcaa  attccgctt  aagcctctg  cagataaaa  900
tcaacagca  cgattacta  acattgcca  gaaggaaaa  gtcaaaatt  gtgatgagg  960
aatagctta  cttgttaaa  tgtcagaag  agacttaag  aaagccatt  catttcttc  1020
aagcgctac  cgattaaca  gtggaaagg  gatcacaga  aaagtgatt  cagacattg  1080
tggggtaat  ccagctgag  aaattgatg  agtatttgc  gcctgtcag  gtggctctt  1140
tgacaaact  gaagctgtg  tcaaggatt  aatagatga  ggtcatgca  caactcagc  1200
cgtcaatca  ctccatgat  tggttgtag  aaataactt  tctgataaa  agaagtcta  1260
tatcacaga  aaacttgcc  aagttgaca  atgcctagc  gatggtgct  atgaacatt  1320
gcaactcat  agcctttgt  caactgtga  gcagcagtt  tctcagaat  gttaacgtg  1380
tatatctgg  tggggggtt  tgtaaataa  gaagttgta  taaaaataa  atgaccaaa  1440
gcaccg  1446



<210> 4827
<211> 363
<212> PRT
<213> Homo sapiens
<308> P35249
<400> 4827

Met Gln Ala Phe Leu Lys Gly Thr Ser Ile Ser Thr Lys Pro Pro Leu 
  1               5                  10                  15
Thr Lys Asp Arg Gly Val Ala Ala Ser Ala Gly Ser Ser Gly Glu Asn 
             20                  25                  30
Lys Lys Ala Lys Pro Val Pro Trp Val Glu Lys Tyr Arg Pro Lys Cys 
         35                  40                  45
Val Asp Glu Val Ala Phe Gln Glu Glu Val Val Ala Val Leu Lys Lys 
     50                  55                  60
Ser Leu Glu Gly Ala Asp Leu Pro Asn Leu Leu Phe Tyr Gly Pro Pro 
 65                  70                  75                  80
Gly Thr Gly Lys Thr Ser Thr Ile Leu Ala Ala Ala Arg Glu Leu Phe 
                 85                  90                  95
Gly Pro Glu Leu Phe Arg Leu Arg Val Leu Glu Leu Asn Ala Ser Asp 
             100                105                110
Glu Arg Gly Ile Gln Val Val Arg Glu Lys Val Lys Asn Phe Ala Gln 
         115                120                125
Leu Thr Val Ser Gly Ser Arg Ser Asp Gly Lys Pro Cys Pro Pro Phe 
     130                135                140
Lys Ile Val Ile Leu Asp Glu Ala Asp Ser Met Thr Ser Ala Ala Gln 
 145                150                155                160
Ala Ala Leu Arg Arg Thr Met Glu Lys Glu Ser Lys Thr Thr Arg Phe 
                 165                170                175
Cys Leu Ile Cys Asn Tyr Val Ser Arg Ile Ile Glu Pro Leu Thr Ser 
             180                185                190
Arg Cys Ser Lys Phe Arg Phe Lys Pro Leu Ser Asp Lys Ile Gln Gln 
         195                200                205
Gln Arg Leu Leu Asp Ile Ala Lys Lys Glu Asn Val Lys Ile Ser Asp 
     210                215                220
Glu Gly Ile Ala Tyr Leu Val Lys Val Ser Glu Gly Asp Leu Arg Lys 
 225                230                235                240
Ala Ile Thr Phe Leu Gln Ser Ala Thr Arg Leu Thr Gly Gly Lys Glu 
                 245                250                255
Ile Thr Glu Lys Val Ile Thr Asp Ile Ala Gly Val Ile Pro Ala Glu 
             260                265                270
Lys Ile Asp Gly Val Phe Ala Ala Cys Gln Ser Gly Ser Phe Asp Lys 
         275                280                285
Leu Glu Ala Val Val Lys Asp Leu Ile Asp Glu Gly His Ala Ala Thr 
     290                295                300
Gln Leu Val Asn Gln Leu His Asp Val Val Val Glu Asn Asn Leu Ser 
 305                310                315                320
Asp Lys Gln Lys Ser Ile Ile Thr Glu Lys Leu Ala Glu Val Asp Lys 
                 325                330                335
Cys Leu Ala Asp Gly Ala Asp Glu His Leu Gln Leu Ile Ser Leu Cys 
             340                345                350
Ala Thr Val Met Gln Gln Leu Ser Gln Asn Cys 
         355                360



<210> 4828
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AA819500
<400> 4828

ttttttttt  tttttttac  ggtggtttg  tcctttatt  ctattattc  tacaaaaga  60
catcgatct  aacagttct  ggtcagttg  tgcatcaca  ttgcgcaga  gctcatcag  120
tgcaggtgc  catctgcac  atctgctaa  cacttatcc  cctcagcaa  tttttctgt  180
atgatggac  tctgtttat  agacagatt  tcatcttct  tgattgaat  atgaagttg  240
ttgacaagc  gagtggctg  atgcccttc  tctattagg  tcttcagca  ggcttctag  300
ttgtcaaaa  agccgctgt  acatgcagt  actattccc  caatggttg  agctggtat  360
accccagca  tgtctgtga  cacatcttc  gagatttcc  ttccacctg  tagtcgagt  420
gcactttga  gaaatgtaa  tgctttccg  aaatctcct  ctgatattc  aacaagata  480
gctatttcc  catcgccaa  tttgacatt  tccttctca  caatatcca  taatcgctt  540
t  541



<210> 4829
<211> 364
<212> PRT
<213> Rattus norvegicus
<308> AAH03335
<400> 4829

Met Gln Ala Phe Leu Lys Gly Thr Ser Val Ser Ala Lys Ala Gln Leu 
  1               5                  10                  15
Thr Lys Asp Arg Gly Thr Pro Ala Thr Ala Gly Ser Ser Gly Glu Thr 
             20                  25                  30
Lys Lys Val Lys Pro Val Pro Trp Val Glu Lys Tyr Arg Pro Lys Cys 
         35                  40                  45
Val Asp Glu Val Ala Phe Gln Asp Glu Val Val Ala Val Leu Arg Lys 
     50                  55                  60
Ser Leu Glu Gly Ala Asp Leu Pro Asn Leu Leu Phe Tyr Gly Pro Pro 
 65                  70                  75                  80
Gly Thr Gly Lys Thr Ser Thr Ile Leu Ala Ala Ala Arg Glu Leu Phe 
                 85                  90                  95
Gly Pro Glu Leu Phe Arg Leu Arg Val Leu Glu Leu Asn Ala Ser Asp 
             100                105                110
Glu Arg Gly Ile Gln Val Val Arg Glu Lys Val Lys Asn Phe Ala Gln 
         115                120                125
Leu Thr Val Ser Gly Ser Arg Ser Asp Gly Lys Pro Cys Pro Pro Phe 
     130                135                140
Lys Ile Val Ile Leu Asp Glu Ala Asp Ser Met Thr Ser Ala Ala Gln 
 145                150                155                160
Ala Ala Leu Arg Arg Thr Met Glu Lys Glu Ser Lys Thr Thr Arg Phe 
                 165                170                175
Cys Leu Ile Cys Asn Tyr Val Ser Arg Ile Ile Glu Pro Leu Thr Ser 
             180                185                190
Arg Cys Ser Lys Phe Arg Phe Lys Pro Leu Ser Asp Lys Ile Gln Gln 
         195                200                205
Glu Arg Leu Leu Asp Ile Ala Glu Lys Glu Asn Val Lys Ile Gly Asn 
     210                215                220
Glu Glu Ile Ala Tyr Leu Val Lys Ile Ser Glu Gly Asp Leu Arg Lys 
 225                230                235                240
Ala Ile Thr Phe Leu Gln Ser Ala Thr Arg Leu Thr Gly Gly Lys Glu 
                 245                250                255
Val Ser Glu Asp Val Ile Thr Asp Ile Ala Gly Val Ile Pro Ala Ala 
             260                265                270
Thr Ile Asp Gly Ile Phe Thr Ala Cys His Ser Gly Ser Phe Asp Lys 
         275                280                285
Leu Glu Ala Val Val Lys Asn Leu Ile Asp Glu Gly His Ala Ala Thr 
     290                295                300
Gln Leu Val Asn Gln Leu His Asp Ala Ile Ile Glu Asn Glu Asn Leu 
 305                310                315                320
Ser Asp Lys His Lys Ser Ile Ile Thr Glu Lys Leu Ala Glu Val Asp 
                 325                330                335
Lys Cys Leu Ala Asp Gly Ala Asp Glu His Leu Gln Leu Met Ser Leu 
             340                345                350
Cys Ala Thr Val Met Gln Gln Leu Thr Gln Asn Cys 
         355                360



<210> 4830
<211> 1446
<212> DNA
<213> Homo sapiens
<308> M87339
<400> 4830

ctgccattt  ggacaagct  gatgatgat  gtttgatag  tccaggggt  cgtgtatag  60
agatgatga  tctgcttca  ccagaatca  aatcttaaa  ggcgggaac  gaggcgact  120
tggggacat  agtgatcgt  agtctcctg  gcccgttat  ctcagatta  gtgacggag  180
taagacttc  agaccatct  gtccttttt  tatcgcgga  acctgagga  cgagccggc  240
gcggtgacc  gcacgagaa  ccaggctaa  tgggtgaag  accatgcaa  catttctta  300
aggtacatc  atcagtact  aacccccgc  gaccaagga  cgaggagta  ctgccagtg  360
gggaagtag  ggagagaac  agaaagcca  acccgttcc  tgggtggaa  aatatcgcc  420
aaaatgtgt  gatgaagtt  ctttccagg  agaagtggt  gcagtgctg  aaaaatctt  480
agaaggagc  gatcttcct  atctcttgt  ttacggacc  cctggaact  gaaaaacat  540
cactatttt  gcagcagct  gagaactct  tgggcctga  cttttccga  taagagttc  600
tgagttaaa  gcatctgat  aacgtggaa  acaagtagt  cgagagaaa  tgaaaaatt  660
tgctcaatt  actgtgtca  gaagtcgct  agatgggaa  ccgtgtccg  cttttaaga  720
tgtgattct  gatgaagca  attctatga  ctcagctgc  caggcagct  taagacgta  780
catggagaa  gagtcgaaa  ccacccgat  ctgtcttat  tgtaactat  tcagtcgaa  840
aattgaacc  ctgacctct  gatgttcaa  attccgctt  aagcctctg  cagataaaa  900
tcaacagca  cgattacta  acattgcca  gaaggaaaa  gtcaaaatt  gtgatgagg  960
aatagctta  cttgttaaa  tgtcagaag  agacttaag  aaagccatt  catttcttc  1020
aagcgctac  cgattaaca  gtggaaagg  gatcacaga  aaagtgatt  cagacattg  1080
tggggtaat  ccagctgag  aaattgatg  agtatttgc  gcctgtcag  gtggctctt  1140
tgacaaact  gaagctgtg  tcaaggatt  aatagatga  ggtcatgca  caactcagc  1200
cgtcaatca  ctccatgat  tggttgtag  aaataactt  tctgataaa  agaagtcta  1260
tatcacaga  aaacttgcc  aagttgaca  atgcctagc  gatggtgct  atgaacatt  1320
gcaactcat  agcctttgt  caactgtga  gcagcagtt  tctcagaat  gttaacgtg  1380
tatatctgg  tggggggtt  tgtaaataa  gaagttgta  taaaaataa  atgaccaaa  1440
gcaccg  1446



<210> 4831
<211> 363
<212> PRT
<213> Homo sapiens
<308> P35249
<400> 4831

Met Gln Ala Phe Leu Lys Gly Thr Ser Ile Ser Thr Lys Pro Pro Leu 
  1               5                  10                  15
Thr Lys Asp Arg Gly Val Ala Ala Ser Ala Gly Ser Ser Gly Glu Asn 
             20                  25                  30
Lys Lys Ala Lys Pro Val Pro Trp Val Glu Lys Tyr Arg Pro Lys Cys 
         35                  40                  45
Val Asp Glu Val Ala Phe Gln Glu Glu Val Val Ala Val Leu Lys Lys 
     50                  55                  60
Ser Leu Glu Gly Ala Asp Leu Pro Asn Leu Leu Phe Tyr Gly Pro Pro 
 65                  70                  75                  80
Gly Thr Gly Lys Thr Ser Thr Ile Leu Ala Ala Ala Arg Glu Leu Phe 
                 85                  90                  95
Gly Pro Glu Leu Phe Arg Leu Arg Val Leu Glu Leu Asn Ala Ser Asp 
             100                105                110
Glu Arg Gly Ile Gln Val Val Arg Glu Lys Val Lys Asn Phe Ala Gln 
         115                120                125
Leu Thr Val Ser Gly Ser Arg Ser Asp Gly Lys Pro Cys Pro Pro Phe 
     130                135                140
Lys Ile Val Ile Leu Asp Glu Ala Asp Ser Met Thr Ser Ala Ala Gln 
 145                150                155                160
Ala Ala Leu Arg Arg Thr Met Glu Lys Glu Ser Lys Thr Thr Arg Phe 
                 165                170                175
Cys Leu Ile Cys Asn Tyr Val Ser Arg Ile Ile Glu Pro Leu Thr Ser 
             180                185                190
Arg Cys Ser Lys Phe Arg Phe Lys Pro Leu Ser Asp Lys Ile Gln Gln 
         195                200                205
Gln Arg Leu Leu Asp Ile Ala Lys Lys Glu Asn Val Lys Ile Ser Asp 
     210                215                220
Glu Gly Ile Ala Tyr Leu Val Lys Val Ser Glu Gly Asp Leu Arg Lys 
 225                230                235                240
Ala Ile Thr Phe Leu Gln Ser Ala Thr Arg Leu Thr Gly Gly Lys Glu 
                 245                250                255
Ile Thr Glu Lys Val Ile Thr Asp Ile Ala Gly Val Ile Pro Ala Glu 
             260                265                270
Lys Ile Asp Gly Val Phe Ala Ala Cys Gln Ser Gly Ser Phe Asp Lys 
         275                280                285
Leu Glu Ala Val Val Lys Asp Leu Ile Asp Glu Gly His Ala Ala Thr 
     290                295                300
Gln Leu Val Asn Gln Leu His Asp Val Val Val Glu Asn Asn Leu Ser 
 305                310                315                320
Asp Lys Gln Lys Ser Ile Ile Thr Glu Lys Leu Ala Glu Val Asp Lys 
                 325                330                335
Cys Leu Ala Asp Gly Ala Asp Glu His Leu Gln Leu Ile Ser Leu Cys 
             340                345                350
Ala Thr Val Met Gln Gln Leu Ser Gln Asn Cys 
         355                360



<210> 4832
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AA819500
<400> 4832

ttttttttt  tttttttac  ggtggtttg  tcctttatt  ctattattc  tacaaaaga  60
catcgatct  aacagttct  ggtcagttg  tgcatcaca  ttgcgcaga  gctcatcag  120
tgcaggtgc  catctgcac  atctgctaa  cacttatcc  cctcagcaa  tttttctgt  180
atgatggac  tctgtttat  agacagatt  tcatcttct  tgattgaat  atgaagttg  240
ttgacaagc  gagtggctg  atgcccttc  tctattagg  tcttcagca  ggcttctag  300
ttgtcaaaa  agccgctgt  acatgcagt  actattccc  caatggttg  agctggtat  360
accccagca  tgtctgtga  cacatcttc  gagatttcc  ttccacctg  tagtcgagt  420
gcactttga  gaaatgtaa  tgctttccg  aaatctcct  ctgatattc  aacaagata  480
gctatttcc  catcgccaa  tttgacatt  tccttctca  caatatcca  taatcgctt  540
t  541



<210> 4833
<211> 364
<212> PRT
<213> Rattus norvegicus
<308> AAH03335
<400> 4833

Met Gln Ala Phe Leu Lys Gly Thr Ser Val Ser Ala Lys Ala Gln Leu 
  1               5                  10                  15
Thr Lys Asp Arg Gly Thr Pro Ala Thr Ala Gly Ser Ser Gly Glu Thr 
             20                  25                  30
Lys Lys Val Lys Pro Val Pro Trp Val Glu Lys Tyr Arg Pro Lys Cys 
         35                  40                  45
Val Asp Glu Val Ala Phe Gln Asp Glu Val Val Ala Val Leu Arg Lys 
     50                  55                  60
Ser Leu Glu Gly Ala Asp Leu Pro Asn Leu Leu Phe Tyr Gly Pro Pro 
 65                  70                  75                  80
Gly Thr Gly Lys Thr Ser Thr Ile Leu Ala Ala Ala Arg Glu Leu Phe 
                 85                  90                  95
Gly Pro Glu Leu Phe Arg Leu Arg Val Leu Glu Leu Asn Ala Ser Asp 
             100                105                110
Glu Arg Gly Ile Gln Val Val Arg Glu Lys Val Lys Asn Phe Ala Gln 
         115                120                125
Leu Thr Val Ser Gly Ser Arg Ser Asp Gly Lys Pro Cys Pro Pro Phe 
     130                135                140
Lys Ile Val Ile Leu Asp Glu Ala Asp Ser Met Thr Ser Ala Ala Gln 
 145                150                155                160
Ala Ala Leu Arg Arg Thr Met Glu Lys Glu Ser Lys Thr Thr Arg Phe 
                 165                170                175
Cys Leu Ile Cys Asn Tyr Val Ser Arg Ile Ile Glu Pro Leu Thr Ser 
             180                185                190
Arg Cys Ser Lys Phe Arg Phe Lys Pro Leu Ser Asp Lys Ile Gln Gln 
         195                200                205
Glu Arg Leu Leu Asp Ile Ala Glu Lys Glu Asn Val Lys Ile Gly Asn 
     210                215                220
Glu Glu Ile Ala Tyr Leu Val Lys Ile Ser Glu Gly Asp Leu Arg Lys 
 225                230                235                240
Ala Ile Thr Phe Leu Gln Ser Ala Thr Arg Leu Thr Gly Gly Lys Glu 
                 245                250                255
Val Ser Glu Asp Val Ile Thr Asp Ile Ala Gly Val Ile Pro Ala Ala 
             260                265                270
Thr Ile Asp Gly Ile Phe Thr Ala Cys His Ser Gly Ser Phe Asp Lys 
         275                280                285
Leu Glu Ala Val Val Lys Asn Leu Ile Asp Glu Gly His Ala Ala Thr 
     290                295                300
Gln Leu Val Asn Gln Leu His Asp Ala Ile Ile Glu Asn Glu Asn Leu 
 305                310                315                320
Ser Asp Lys His Lys Ser Ile Ile Thr Glu Lys Leu Ala Glu Val Asp 
                 325                330                335
Lys Cys Leu Ala Asp Gly Ala Asp Glu His Leu Gln Leu Met Ser Leu 
             340                345                350
Cys Ala Thr Val Met Gln Gln Leu Thr Gln Asn Cys 
         355                360



<210> 4834
<211> 1446
<212> DNA
<213> Homo sapiens
<308> M87339
<400> 4834

ctgccattt  ggacaagct  gatgatgat  gtttgatag  tccaggggt  cgtgtatag  60
agatgatga  tctgcttca  ccagaatca  aatcttaaa  ggcgggaac  gaggcgact  120
tggggacat  agtgatcgt  agtctcctg  gcccgttat  ctcagatta  gtgacggag  180
taagacttc  agaccatct  gtccttttt  tatcgcgga  acctgagga  cgagccggc  240
gcggtgacc  gcacgagaa  ccaggctaa  tgggtgaag  accatgcaa  catttctta  300
aggtacatc  atcagtact  aacccccgc  gaccaagga  cgaggagta  ctgccagtg  360
gggaagtag  ggagagaac  agaaagcca  acccgttcc  tgggtggaa  aatatcgcc  420
aaaatgtgt  gatgaagtt  ctttccagg  agaagtggt  gcagtgctg  aaaaatctt  480
agaaggagc  gatcttcct  atctcttgt  ttacggacc  cctggaact  gaaaaacat  540
cactatttt  gcagcagct  gagaactct  tgggcctga  cttttccga  taagagttc  600
tgagttaaa  gcatctgat  aacgtggaa  acaagtagt  cgagagaaa  tgaaaaatt  660
tgctcaatt  actgtgtca  gaagtcgct  agatgggaa  ccgtgtccg  cttttaaga  720
tgtgattct  gatgaagca  attctatga  ctcagctgc  caggcagct  taagacgta  780
catggagaa  gagtcgaaa  ccacccgat  ctgtcttat  tgtaactat  tcagtcgaa  840
aattgaacc  ctgacctct  gatgttcaa  attccgctt  aagcctctg  cagataaaa  900
tcaacagca  cgattacta  acattgcca  gaaggaaaa  gtcaaaatt  gtgatgagg  960
aatagctta  cttgttaaa  tgtcagaag  agacttaag  aaagccatt  catttcttc  1020
aagcgctac  cgattaaca  gtggaaagg  gatcacaga  aaagtgatt  cagacattg  1080
tggggtaat  ccagctgag  aaattgatg  agtatttgc  gcctgtcag  gtggctctt  1140
tgacaaact  gaagctgtg  tcaaggatt  aatagatga  ggtcatgca  caactcagc  1200
cgtcaatca  ctccatgat  tggttgtag  aaataactt  tctgataaa  agaagtcta  1260
tatcacaga  aaacttgcc  aagttgaca  atgcctagc  gatggtgct  atgaacatt  1320
gcaactcat  agcctttgt  caactgtga  gcagcagtt  tctcagaat  gttaacgtg  1380
tatatctgg  tggggggtt  tgtaaataa  gaagttgta  taaaaataa  atgaccaaa  1440
gcaccg  1446



<210> 4835
<211> 363
<212> PRT
<213> Homo sapiens
<308> P35249
<400> 4835

Met Gln Ala Phe Leu Lys Gly Thr Ser Ile Ser Thr Lys Pro Pro Leu 
  1               5                  10                  15
Thr Lys Asp Arg Gly Val Ala Ala Ser Ala Gly Ser Ser Gly Glu Asn 
             20                  25                  30
Lys Lys Ala Lys Pro Val Pro Trp Val Glu Lys Tyr Arg Pro Lys Cys 
         35                  40                  45
Val Asp Glu Val Ala Phe Gln Glu Glu Val Val Ala Val Leu Lys Lys 
     50                  55                  60
Ser Leu Glu Gly Ala Asp Leu Pro Asn Leu Leu Phe Tyr Gly Pro Pro 
 65                  70                  75                  80
Gly Thr Gly Lys Thr Ser Thr Ile Leu Ala Ala Ala Arg Glu Leu Phe 
                 85                  90                  95
Gly Pro Glu Leu Phe Arg Leu Arg Val Leu Glu Leu Asn Ala Ser Asp 
             100                105                110
Glu Arg Gly Ile Gln Val Val Arg Glu Lys Val Lys Asn Phe Ala Gln 
         115                120                125
Leu Thr Val Ser Gly Ser Arg Ser Asp Gly Lys Pro Cys Pro Pro Phe 
     130                135                140
Lys Ile Val Ile Leu Asp Glu Ala Asp Ser Met Thr Ser Ala Ala Gln 
 145                150                155                160
Ala Ala Leu Arg Arg Thr Met Glu Lys Glu Ser Lys Thr Thr Arg Phe 
                 165                170                175
Cys Leu Ile Cys Asn Tyr Val Ser Arg Ile Ile Glu Pro Leu Thr Ser 
             180                185                190
Arg Cys Ser Lys Phe Arg Phe Lys Pro Leu Ser Asp Lys Ile Gln Gln 
         195                200                205
Gln Arg Leu Leu Asp Ile Ala Lys Lys Glu Asn Val Lys Ile Ser Asp 
     210                215                220
Glu Gly Ile Ala Tyr Leu Val Lys Val Ser Glu Gly Asp Leu Arg Lys 
 225                230                235                240
Ala Ile Thr Phe Leu Gln Ser Ala Thr Arg Leu Thr Gly Gly Lys Glu 
                 245                250                255
Ile Thr Glu Lys Val Ile Thr Asp Ile Ala Gly Val Ile Pro Ala Glu 
             260                265                270
Lys Ile Asp Gly Val Phe Ala Ala Cys Gln Ser Gly Ser Phe Asp Lys 
         275                280                285
Leu Glu Ala Val Val Lys Asp Leu Ile Asp Glu Gly His Ala Ala Thr 
     290                295                300
Gln Leu Val Asn Gln Leu His Asp Val Val Val Glu Asn Asn Leu Ser 
 305                310                315                320
Asp Lys Gln Lys Ser Ile Ile Thr Glu Lys Leu Ala Glu Val Asp Lys 
                 325                330                335
Cys Leu Ala Asp Gly Ala Asp Glu His Leu Gln Leu Ile Ser Leu Cys 
             340                345                350
Ala Thr Val Met Gln Gln Leu Ser Gln Asn Cys 
         355                360



<210> 4836
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AA819500
<400> 4836

ttttttttt  tttttttac  ggtggtttg  tcctttatt  ctattattc  tacaaaaga  60
catcgatct  aacagttct  ggtcagttg  tgcatcaca  ttgcgcaga  gctcatcag  120
tgcaggtgc  catctgcac  atctgctaa  cacttatcc  cctcagcaa  tttttctgt  180
atgatggac  tctgtttat  agacagatt  tcatcttct  tgattgaat  atgaagttg  240
ttgacaagc  gagtggctg  atgcccttc  tctattagg  tcttcagca  ggcttctag  300
ttgtcaaaa  agccgctgt  acatgcagt  actattccc  caatggttg  agctggtat  360
accccagca  tgtctgtga  cacatcttc  gagatttcc  ttccacctg  tagtcgagt  420
gcactttga  gaaatgtaa  tgctttccg  aaatctcct  ctgatattc  aacaagata  480
gctatttcc  catcgccaa  tttgacatt  tccttctca  caatatcca  taatcgctt  540
t  541



<210> 4837
<211> 364
<212> PRT
<213> Rattus norvegicus
<308> AAH03335
<400> 4837

Met Gln Ala Phe Leu Lys Gly Thr Ser Val Ser Ala Lys Ala Gln Leu 
  1               5                  10                  15
Thr Lys Asp Arg Gly Thr Pro Ala Thr Ala Gly Ser Ser Gly Glu Thr 
             20                  25                  30
Lys Lys Val Lys Pro Val Pro Trp Val Glu Lys Tyr Arg Pro Lys Cys 
         35                  40                  45
Val Asp Glu Val Ala Phe Gln Asp Glu Val Val Ala Val Leu Arg Lys 
     50                  55                  60
Ser Leu Glu Gly Ala Asp Leu Pro Asn Leu Leu Phe Tyr Gly Pro Pro 
 65                  70                  75                  80
Gly Thr Gly Lys Thr Ser Thr Ile Leu Ala Ala Ala Arg Glu Leu Phe 
                 85                  90                  95
Gly Pro Glu Leu Phe Arg Leu Arg Val Leu Glu Leu Asn Ala Ser Asp 
             100                105                110
Glu Arg Gly Ile Gln Val Val Arg Glu Lys Val Lys Asn Phe Ala Gln 
         115                120                125
Leu Thr Val Ser Gly Ser Arg Ser Asp Gly Lys Pro Cys Pro Pro Phe 
     130                135                140
Lys Ile Val Ile Leu Asp Glu Ala Asp Ser Met Thr Ser Ala Ala Gln 
 145                150                155                160
Ala Ala Leu Arg Arg Thr Met Glu Lys Glu Ser Lys Thr Thr Arg Phe 
                 165                170                175
Cys Leu Ile Cys Asn Tyr Val Ser Arg Ile Ile Glu Pro Leu Thr Ser 
             180                185                190
Arg Cys Ser Lys Phe Arg Phe Lys Pro Leu Ser Asp Lys Ile Gln Gln 
         195                200                205
Glu Arg Leu Leu Asp Ile Ala Glu Lys Glu Asn Val Lys Ile Gly Asn 
     210                215                220
Glu Glu Ile Ala Tyr Leu Val Lys Ile Ser Glu Gly Asp Leu Arg Lys 
 225                230                235                240
Ala Ile Thr Phe Leu Gln Ser Ala Thr Arg Leu Thr Gly Gly Lys Glu 
                 245                250                255
Val Ser Glu Asp Val Ile Thr Asp Ile Ala Gly Val Ile Pro Ala Ala 
             260                265                270
Thr Ile Asp Gly Ile Phe Thr Ala Cys His Ser Gly Ser Phe Asp Lys 
         275                280                285
Leu Glu Ala Val Val Lys Asn Leu Ile Asp Glu Gly His Ala Ala Thr 
     290                295                300
Gln Leu Val Asn Gln Leu His Asp Ala Ile Ile Glu Asn Glu Asn Leu 
 305                310                315                320
Ser Asp Lys His Lys Ser Ile Ile Thr Glu Lys Leu Ala Glu Val Asp 
                 325                330                335
Lys Cys Leu Ala Asp Gly Ala Asp Glu His Leu Gln Leu Met Ser Leu 
             340                345                350
Cys Ala Thr Val Met Gln Gln Leu Thr Gln Asn Cys 
         355                360



<210> 4838
<211> 1446
<212> DNA
<213> Homo sapiens
<308> M87339
<400> 4838

ctgccattt  ggacaagct  gatgatgat  gtttgatag  tccaggggt  cgtgtatag  60
agatgatga  tctgcttca  ccagaatca  aatcttaaa  ggcgggaac  gaggcgact  120
tggggacat  agtgatcgt  agtctcctg  gcccgttat  ctcagatta  gtgacggag  180
taagacttc  agaccatct  gtccttttt  tatcgcgga  acctgagga  cgagccggc  240
gcggtgacc  gcacgagaa  ccaggctaa  tgggtgaag  accatgcaa  catttctta  300
aggtacatc  atcagtact  aacccccgc  gaccaagga  cgaggagta  ctgccagtg  360
gggaagtag  ggagagaac  agaaagcca  acccgttcc  tgggtggaa  aatatcgcc  420
aaaatgtgt  gatgaagtt  ctttccagg  agaagtggt  gcagtgctg  aaaaatctt  480
agaaggagc  gatcttcct  atctcttgt  ttacggacc  cctggaact  gaaaaacat  540
cactatttt  gcagcagct  gagaactct  tgggcctga  cttttccga  taagagttc  600
tgagttaaa  gcatctgat  aacgtggaa  acaagtagt  cgagagaaa  tgaaaaatt  660
tgctcaatt  actgtgtca  gaagtcgct  agatgggaa  ccgtgtccg  cttttaaga  720
tgtgattct  gatgaagca  attctatga  ctcagctgc  caggcagct  taagacgta  780
catggagaa  gagtcgaaa  ccacccgat  ctgtcttat  tgtaactat  tcagtcgaa  840
aattgaacc  ctgacctct  gatgttcaa  attccgctt  aagcctctg  cagataaaa  900
tcaacagca  cgattacta  acattgcca  gaaggaaaa  gtcaaaatt  gtgatgagg  960
aatagctta  cttgttaaa  tgtcagaag  agacttaag  aaagccatt  catttcttc  1020
aagcgctac  cgattaaca  gtggaaagg  gatcacaga  aaagtgatt  cagacattg  1080
tggggtaat  ccagctgag  aaattgatg  agtatttgc  gcctgtcag  gtggctctt  1140
tgacaaact  gaagctgtg  tcaaggatt  aatagatga  ggtcatgca  caactcagc  1200
cgtcaatca  ctccatgat  tggttgtag  aaataactt  tctgataaa  agaagtcta  1260
tatcacaga  aaacttgcc  aagttgaca  atgcctagc  gatggtgct  atgaacatt  1320
gcaactcat  agcctttgt  caactgtga  gcagcagtt  tctcagaat  gttaacgtg  1380
tatatctgg  tggggggtt  tgtaaataa  gaagttgta  taaaaataa  atgaccaaa  1440
gcaccg  1446



<210> 4839
<211> 363
<212> PRT
<213> Homo sapiens
<308> P35249
<400> 4839

Met Gln Ala Phe Leu Lys Gly Thr Ser Ile Ser Thr Lys Pro Pro Leu 
  1               5                  10                  15
Thr Lys Asp Arg Gly Val Ala Ala Ser Ala Gly Ser Ser Gly Glu Asn 
             20                  25                  30
Lys Lys Ala Lys Pro Val Pro Trp Val Glu Lys Tyr Arg Pro Lys Cys 
         35                  40                  45
Val Asp Glu Val Ala Phe Gln Glu Glu Val Val Ala Val Leu Lys Lys 
     50                  55                  60
Ser Leu Glu Gly Ala Asp Leu Pro Asn Leu Leu Phe Tyr Gly Pro Pro 
 65                  70                  75                  80
Gly Thr Gly Lys Thr Ser Thr Ile Leu Ala Ala Ala Arg Glu Leu Phe 
                 85                  90                  95
Gly Pro Glu Leu Phe Arg Leu Arg Val Leu Glu Leu Asn Ala Ser Asp 
             100                105                110
Glu Arg Gly Ile Gln Val Val Arg Glu Lys Val Lys Asn Phe Ala Gln 
         115                120                125
Leu Thr Val Ser Gly Ser Arg Ser Asp Gly Lys Pro Cys Pro Pro Phe 
     130                135                140
Lys Ile Val Ile Leu Asp Glu Ala Asp Ser Met Thr Ser Ala Ala Gln 
 145                150                155                160
Ala Ala Leu Arg Arg Thr Met Glu Lys Glu Ser Lys Thr Thr Arg Phe 
                 165                170                175
Cys Leu Ile Cys Asn Tyr Val Ser Arg Ile Ile Glu Pro Leu Thr Ser 
             180                185                190
Arg Cys Ser Lys Phe Arg Phe Lys Pro Leu Ser Asp Lys Ile Gln Gln 
         195                200                205
Gln Arg Leu Leu Asp Ile Ala Lys Lys Glu Asn Val Lys Ile Ser Asp 
     210                215                220
Glu Gly Ile Ala Tyr Leu Val Lys Val Ser Glu Gly Asp Leu Arg Lys 
 225                230                235                240
Ala Ile Thr Phe Leu Gln Ser Ala Thr Arg Leu Thr Gly Gly Lys Glu 
                 245                250                255
Ile Thr Glu Lys Val Ile Thr Asp Ile Ala Gly Val Ile Pro Ala Glu 
             260                265                270
Lys Ile Asp Gly Val Phe Ala Ala Cys Gln Ser Gly Ser Phe Asp Lys 
         275                280                285
Leu Glu Ala Val Val Lys Asp Leu Ile Asp Glu Gly His Ala Ala Thr 
     290                295                300
Gln Leu Val Asn Gln Leu His Asp Val Val Val Glu Asn Asn Leu Ser 
 305                310                315                320
Asp Lys Gln Lys Ser Ile Ile Thr Glu Lys Leu Ala Glu Val Asp Lys 
                 325                330                335
Cys Leu Ala Asp Gly Ala Asp Glu His Leu Gln Leu Ile Ser Leu Cys 
             340                345                350
Ala Thr Val Met Gln Gln Leu Ser Gln Asn Cys 
         355                360



<210> 4840
<211> 565
<212> DNA
<213> Rattus norvegicus
<308> AA848545
<400> 4840

aacagatgt  aactattta  tgaatattt  ccaccaaat  ttgttaaat  cattatctt  60
cagcatatc  ctttcaagt  aaaatgtca  aaacaaaca  caatattta  atttcttgt  120
aggaatgtt  tataatgac  cattaaggc  taaattctt  tggcttata  ttcttaaaa  180
aatgataat  gcaaaagtg  tgcaaaatc  tcagtgtga  gttatgatt  agctacatt  240
tacaaaaat  cggtgtaag  tggcgataa  cccattcaa  atcctggat  agacccctc  300
ggagggctg  taatttata  agtcagact  taaatttac  gataagtgc  gtttaatac  360
gccactgag  agtacatct  tgaacatat  cagcttcag  ccacagttt  gaaggtctg  420
agtatcaag  tggtttgat  aattagccg  ttggcactt  tgaacacat  tattgcctt  480
ccatcttta  aatatgtct  cagagtgtc  ctgaaactt  tggagtatt  tacaaattc  540
ttcttttgg  ttcaagtgc  ctgcg  565



<210> 4841
<211> 212
<212> PRT
<213> Rattus norvegicus
<308> NP_062719
<400> 4841

Met Arg Met Thr Met Glu Glu Met Lys Asn Glu Ala Glu Thr Thr Ser 
  1               5                  10                  15
Met Val Ser Met Pro Leu Tyr Ala Val Met Tyr Pro Val Phe Asn Glu 
             20                  25                  30
Leu Glu Arg Val Asn Leu Ser Ala Ala Gln Thr Leu Arg Ala Ala Phe 
         35                  40                  45
Ile Lys Ala Glu Lys Glu Asn Pro Gly Leu Thr Gln Asp Ile Ile Met 
     50                  55                  60
Lys Ile Leu Glu Lys Lys Ser Val Glu Val Asn Phe Thr Glu Ser Leu 
 65                  70                  75                  80
Leu Arg Met Ala Ala Asp Asp Val Glu Glu Tyr Met Ile Glu Arg Pro 
                 85                  90                  95
Glu Pro Glu Phe Gln Asp Leu Asn Glu Lys Ala Arg Ala Leu Lys Gln 
             100                105                110
Ile Leu Ser Lys Ile Pro Asp Glu Ile Asn Asp Arg Val Arg Phe Leu 
         115                120                125
Gln Thr Ile Lys Asp Ile Ala Ser Ala Ile Lys Glu Leu Leu Asp Thr 
     130                135                140
Val Asn Asn Val Phe Lys Lys Tyr Gln Tyr Gln Asn Arg Arg Gln Leu 
 145                150                155                160
Glu His Gln Lys Lys Glu Phe Val Lys Tyr Ser Lys Ser Phe Ser Asp 
                 165                170                175
Thr Leu Lys Thr Tyr Phe Lys Asp Gly Lys Ala Ile Asn Val Phe Ile 
             180                185                190
Ser Ala Asn Arg Leu Ile His Gln Thr Asn Leu Ile Leu Gln Thr Phe 
         195                200                205
Lys Thr Val Ala 
     210



<210> 4842
<211> 1466
<212> DNA
<213> Homo sapiens
<308> BC002506
<400> 4842

ggcctgggt  gcggtaagg  gtagctgtt  tgtcccagt  cccgtagct  tgcaccgag  60
agaagaggt  tagggtcac  caggggcca  ggctgaggc  cttgggctt  gttctggca  120
gcggagcgg  cggggctga  agcggggcc  tacgggcgg  agaggagca  tggaagaag  180
aagagacaa  tgttggggt  tacggattc  gttccagtt  aatgatgtg  ccctctaag  240
agataattt  gccttaaac  gaaagactt  accctctta  gtgtcatac  taagatcag  300
gtgtttttt  tgtccaatt  ttttatcac  aaaaaagag  agaaatatt  cagtgaatg  360
agattcctc  gcattttag  actgctttt  caactgtag  tggcttttg  atgaggatg  420
caatggaag  gatgaagaa  gaagctgag  ccacatcca  ggtttctat  cccctctat  480
cagtcatgt  tcctgtgtt  aatgagcta  aacgagtaa  tctgtctgc  gcccagaca  540
tgagagccg  tttcatcaa  gctgaaaaa  aaaatccag  tctcacaca  gacatcatt  600
tgaaaattt  agagaaaaa  agcgtggaa  ttaacttca  ggagtccct  cttcgtatg  660
cagctgatg  tgtagaaga  tatatgatt  aacgaccag  gccagaatt  caagaccta  720
acgaaaagg  acgagcact  aaacaaatt  tcagtaaga  cccagatga  atcaatgac  780
gagtgaggt  tctgcagac  atcaaggat  tagctagtg  aataaaaga  cttcttgat  840
cagtgaata  tgtcttcaa  aaatatcaa  accagaacc  cagggcact  gaacaccaa  900
agaaagaat  tgtaaagta  tccaaaagt  tcagtgata  tctgaaaac  tattttaaa  960
atggcaagg  aataaatgt  ttcgtaagt  ccaaccgac  aattcatca  accaactta  1020
tacttcaga  cttcaaaac  gtggcctga  agttgtata  gttaagaga  gtacttctc  1080
gtggcagta  tgaactgcc  ttatctgta  attttaaag  ttgactgta  aaattatca  1140
tccctcctg  agggatcta  tccaggatg  tgaatggga  tattgccat  ttacaccat  1200
tttttgtaa  atgtagctt  atcataatc  cacactgaa  attttgcat  acttttgct  1260
ttatcattc  tttaagaat  ataagccaa  agaatttac  ccttaatgt  tcattatat  1320
acattcctt  aaagaattg  aaatattgg  gtttgtttc  gacatttta  cttgaaagc  1380
atatgctgc  agataatgt  tttaacaat  tttggtggc  aatattcaa  aaatagttt  1440
catctgtta  aaaaaaaaa  aaaaaa  1466



<210> 4843
<211> 212
<212> PRT
<213> Homo sapiens
<308> AAH02506
<400> 4843

Met Arg Met Thr Met Glu Glu Met Lys Asn Glu Ala Glu Thr Thr Ser 
  1               5                  10                  15
Met Val Ser Met Pro Leu Tyr Ala Val Met Tyr Pro Val Phe Asn Glu 
             20                  25                  30
Leu Glu Arg Val Asn Leu Ser Ala Ala Gln Thr Leu Arg Ala Ala Phe 
         35                  40                  45
Ile Lys Ala Glu Lys Glu Asn Pro Gly Leu Thr Gln Asp Ile Ile Met 
     50                  55                  60
Lys Ile Leu Glu Lys Lys Ser Val Glu Val Asn Phe Thr Glu Ser Leu 
 65                  70                  75                  80
Leu Arg Met Ala Ala Asp Asp Val Glu Glu Tyr Met Ile Glu Arg Pro 
                 85                  90                  95
Glu Pro Glu Phe Gln Asp Leu Asn Glu Lys Ala Arg Ala Leu Lys Gln 
             100                105                110
Ile Leu Ser Lys Ile Pro Asp Glu Ile Asn Asp Arg Val Arg Phe Leu 
         115                120                125
Gln Thr Ile Lys Asp Ile Ala Ser Ala Ile Lys Glu Leu Leu Asp Thr 
     130                135                140
Val Asn Asn Val Phe Lys Lys Tyr Gln Tyr Gln Asn Arg Arg Ala Leu 
 145                150                155                160
Glu His Gln Lys Lys Glu Phe Val Lys Tyr Ser Lys Ser Phe Ser Asp 
                 165                170                175
Thr Leu Lys Thr Tyr Phe Lys Asp Gly Lys Ala Ile Asn Val Phe Val 
             180                185                190
Ser Ala Asn Arg Leu Ile His Gln Thr Asn Leu Ile Leu Gln Thr Phe 
         195                200                205
Lys Thr Val Ala 
     210



<210> 4844
<211> 525
<212> DNA
<213> Rattus norvegicus
<308> AA848831
<400> 4844

aaagaaagg  atactgcat  cacacatca  atgcttgct  tctaaacaa  acatgaaaa  60
cattctaat  tatagtttt  ctccatcgt  gataaaaat  catctaagt  agtttagca  120
tcttctcga  cacaaacat  ctgtcagac  tatacatac  tattaataa  tgcaatgtg  180
tgtttgttc  ttaaagggg  agcctgtgt  aattgtgta  ttgatttgg  agatttgtt  240
ttttttttc  ggcttaggc  aaaccacat  aaatctttt  agtctagtt  gtgaaggct  300
catacacgg  ctccccaga  tccgtttct  aattccact  caagacggt  cccttctct  360
ttccaaagg  gaagatggg  gctaccaag  aagttcatc  taaagtctc  tgggtctag  420
gacaaatac  gccattggt  agtgttaag  acaggagtg  cttcgtctc  tctggcgcc  480
caccttgcc  tggcaatgc  ggtaaggtg  ggttcacag  tccac  525



<210> 4845
<211> 364
<212> PRT
<213> Rattus norvegicus
<308> Q61130
<400> 4845

Met Ala Ala Ala Ser Thr Ser Ser Pro Val Ile Ser Gln Pro Gln Phe 
  1               5                  10                  15
Thr Ala Met Asn Glu Gln Gln Cys Phe Tyr Asn Glu Ser Ile Ala Phe 
             20                  25                  30
Phe Tyr Asn Arg Ser Gly Lys Tyr Leu Ala Thr Glu Trp Asn Thr Val 
         35                  40                  45
Ser Lys Leu Val Met Gly Leu Gly Ile Thr Val Cys Val Phe Ile Met 
     50                  55                  60
Leu Ala Asn Leu Leu Val Met Val Ala Ile Tyr Val Asn Arg Arg Phe 
 65                  70                  75                  80
His Phe Pro Ile Tyr Tyr Leu Met Ala Asn Leu Ala Ala Ala Asp Phe 
                 85                  90                  95
Phe Ala Gly Leu Ala Tyr Phe Tyr Leu Met Phe Asn Thr Gly Pro Asn 
             100                105                110
Thr Arg Arg Leu Thr Val Ser Thr Trp Leu Leu Arg Gln Gly Leu Ile 
         115                120                125
Asp Thr Ser Leu Thr Ala Ser Val Ala Asn Leu Leu Ala Ile Ala Ile 
     130                135                140
Glu Arg His Ile Thr Val Phe Arg Met Gln Leu His Thr Arg Met Ser 
 145                150                155                160
Asn Arg Arg Val Val Val Val Ile Val Val Ile Trp Thr Met Ala Ile 
                 165                170                175
Val Met Gly Ala Ile Pro Ser Val Gly Trp Asn Cys Ile Cys Asp Ile 
             180                185                190
Asp His Cys Ser Asn Met Ala Pro Leu Tyr Ser Asp Ser Tyr Leu Val 
         195                200                205
Phe Trp Ala Ile Phe Asn Leu Val Thr Phe Val Val Met Val Val Leu 
     210                215                220
Tyr Ala His Ile Phe Gly Tyr Val Arg Gln Arg Thr Met Arg Met Ser 
 225                230                235                240
Arg His Ser Ser Gly Pro Arg Arg Asn Arg Asp Thr Met Met Ser Leu 
                 245                250                255
Leu Lys Thr Val Val Ile Val Leu Gly Ala Phe Ile Val Cys Trp Thr 
             260                265                270
Pro Gly Leu Val Leu Leu Leu Leu Asp Val Cys Cys Pro Gln Cys Asp 
         275                280                285
Val Leu Ala Tyr Glu Lys Phe Phe Leu Leu Leu Ala Glu Phe Asn Ser 
     290                295                300
Ala Met Asn Pro Ile Ile Tyr Ser Tyr Arg Asp Lys Glu Met Ser Ala 
 305                310                315                320
Thr Phe Arg Gln Ile Leu Cys Cys Gln Arg Asn Glu Asn Pro Asn Gly 
                 325                330                335
Pro Thr Glu Gly Ser Asp Arg Ser Ala Ser Ser Leu Asn His Thr Ile 
             340                345                350
Leu Ala Gly Val His Ser Asn Asp His Ser Val Val 
         355                360



<210> 4846
<211> 2687
<212> DNA
<213> Homo sapiens
<308> NM_001401
<400> 4846

acggcgcgc  gggctcaca  tgtcccgcc  cggacgggc  ttgtggttg  gggcgcgcg  60
gcgagtgcc  gtgagagtg  gggtgcgcg  tgtgggccg  ggcgcgggt  ggtggccgt  120
cgttcttgc  agccggcct  caggaggcg  ggctcccct  gcctcccgc  cccagcggc  180
gaccgagcc  ctggaggga  gttgccgca  ccgcccggg  cgccggccc  cctgtcccg  240
gccaggtac  cagcttctc  tagcatgac  tcgatctga  cagcaaaca  gaaaatttg  300
ctcccgtag  tctggggcg  gttcaccac  tacaaccac  gagctgtca  ggctgccat  360
tctacttcc  tccctgtaa  ttcacagcc  cagttcaca  ccatgaatg  accacagtg  420
ttctacaac  agtccattg  cttctttta  aaccgaagt  gaaagcatc  tgccacaga  480
tggaacaca  tcagcaagc  ggtgatggg  cttggaatc  ctgtttgta  cttcatcat  540
ttggccaac  tattggtca  ggtggcaat  tatgtcaac  gccgcttcc  ttttcctat  600
tattaccta  tggctaatc  ggctgctgc  gacttcttt  ctgggttgg  ctacttcta  660
ctcatgttc  acacaggac  caatactcg  agactgact  ttagcacat  gctcctgcg  720
cagggcctc  ttgacacca  cctgacggc  tctgtggcc  acttactgg  tattgcaat  780
gagaggcac  ttacggttt  ccgcatgca  ctccacaca  ggatgagca  ccggcgggt  840
gtggtggtc  ttgtggtca  ctggactat  gccatcgtt  tgggtgcta  acccagtgt  900
ggctggaac  gtatctgtg  tattgaaaa  tgttccaac  tggcacccc  ctacagtga  960
tcttactta  tcttctggg  cattttcaa  ttggtgacc  ttgtggtaa  ggtggttct  1020
tatgctcac  tctttggct  tgttcgcca  aggactatg  gaatgtctc  gcatagttc  1080
ggaccccgg  ggaatcggg  taccatgat  agtcttctg  agactgtgg  cattgtgct  1140
ggggccttt  tcatctgct  gactcctgg  ttggttttg  tacttctag  cgtgtgctg  1200
ccacagtgc  acgtgctgg  ctatgagaa  ttcttcctt  tccttgctg  attcaactc  1260
gccatgaac  ccatcattt  ctcctaccg  gacaaagaa  tgagcgcca  ctttaggca  1320
atcctctgc  gccagcgca  tgagaaccc  accggcccc  cagaaggct  agaccgctc  1380
gcttcctcc  tcaaccaca  catcttggc  ggagttcac  gcaatgacc  ctctgtggt  1440
tagaacgga  actgagatg  ggaaccagc  gtcctctct  ggaggataa  cagcctccc  1500
ctacccaat  gccagggca  ggtggggtg  gagagagga  aaaagtcaa  tcatgtact  1560
aaacactaa  caatgacag  atttgttcc  ggaccccac  agacttgat  tatattgaa  1620
attagctta  gtgacaacc  tcatcttga  ccccatccc  tctgaaagt  ggaagttgg  1680
gctcttgca  tggaattca  gaacagact  tggagtgtc  atttagact  cactaacta  1740
acttttaaa  gattttgtg  ggtttggtg  aagtcagaa  aaattctgg  tagttgaat  1800
cacaacttc  tttatatac  ggcttccct  ttttatttt  aaaggatac  tttcactta  1860
taaacacgt  tatgcctat  agcatgttt  tgatggatg  gactatgga  tgcttttaa  1920
ctaccataa  tccattttt  cccttacat  ggaaaactg  aagttggaa  tatcttttg  1980
ttagaaagc  tgcatgtaa  gtatgtatg  agtatgcct  acttaaaaa  attaaaagg  2040
tactaatgt  aaatcttct  ggaaataga  cctagactt  aaagccagt  tttgtttag  2100
tcatgaagc  aacaatgct  taatcacaa  attaactgt  taattaaaa  gttgtaaca  2160
gtataaaac  gggaatgta  gtttattac  aaagtgata  gtattccaa  aaagtcata  2220
aagatgaag  actataata  tgttcccat  tatttaaaa  acccaagta  attctaatt  2280
ccagtatat  agaggaaaa  tttcgtagt  tttgtaaaa  aatatactc  tcatagaaa  2340
cttgaaaaa  gcagaaatg  ataaaaaag  aaaaatgat  actgataat  tcacaaccc  2400
gaagtaacc  cctttaaaa  gcaaccccc  tgtatgcct  tatgtgtat  gtatacttt  2460
tttacataa  tggagtcat  ctgtaaaca  ttttataag  agatctttt  cattgcaaa  2520
ttgccacat  ttcttatgg  attaaaaat  ttacaaaaa  ataatttta  tggctatat  2580
atattccat  taatggatg  aactcagtt  atttaacca  tcccatgtt  ttaactatt  2640
aggttgttt  taattttca  tattataaa  ttgcagaaa  ttggtgt  2687



<210> 4847
<211> 364
<212> PRT
<213> Homo sapiens
<308> Q92633
<400> 4847

Met Ala Ala Ile Ser Thr Ser Ile Pro Val Ile Ser Gln Pro Gln Phe 
  1               5                  10                  15
Thr Ala Met Asn Glu Pro Gln Cys Phe Tyr Asn Glu Ser Ile Ala Phe 
             20                  25                  30
Phe Tyr Asn Arg Ser Gly Lys His Leu Ala Thr Glu Trp Asn Thr Val 
         35                  40                  45
Ser Lys Leu Val Met Gly Leu Gly Ile Thr Val Cys Ile Phe Ile Met 
     50                  55                  60
Leu Ala Asn Leu Leu Val Met Val Ala Ile Tyr Val Asn Arg Arg Phe 
 65                  70                  75                  80
His Phe Pro Ile Tyr Tyr Leu Met Ala Asn Leu Ala Ala Ala Asp Phe 
                 85                  90                  95
Phe Ala Gly Leu Ala Tyr Phe Tyr Leu Met Phe Asn Thr Gly Pro Asn 
             100                105                110
Thr Arg Arg Leu Thr Val Ser Thr Trp Leu Leu Arg Gln Gly Leu Ile 
         115                120                125
Asp Thr Ser Leu Thr Ala Ser Val Ala Asn Leu Leu Ala Ile Ala Ile 
     130                135                140
Glu Arg His Ile Thr Val Phe Arg Met Gln Leu His Thr Arg Met Ser 
 145                150                155                160
Asn Arg Arg Val Val Val Val Ile Val Val Ile Trp Thr Met Ala Ile 
                 165                170                175
Val Met Gly Ala Ile Pro Ser Val Gly Trp Asn Cys Ile Cys Asp Ile 
             180                185                190
Glu Asn Cys Ser Asn Met Ala Pro Leu Tyr Ser Asp Ser Tyr Leu Val 
         195                200                205
Phe Trp Ala Ile Phe Asn Leu Val Thr Phe Val Val Met Val Val Leu 
     210                215                220
Tyr Ala His Ile Phe Gly Tyr Val Arg Gln Arg Thr Met Arg Met Ser 
 225                230                235                240
Arg His Ser Ser Gly Pro Arg Arg Asn Arg Asp Thr Met Met Ser Leu 
                 245                250                255
Leu Lys Thr Val Val Ile Val Leu Gly Ala Phe Ile Ile Cys Trp Thr 
             260                265                270
Pro Gly Leu Val Leu Leu Leu Leu Asp Val Cys Cys Pro Gln Cys Asp 
         275                280                285
Val Leu Ala Tyr Glu Lys Phe Phe Leu Leu Leu Ala Glu Phe Asn Ser 
     290                295                300
Ala Met Asn Pro Ile Ile Tyr Ser Tyr Arg Asp Lys Glu Met Ser Ala 
 305                310                315                320
Thr Phe Arg Gln Ile Leu Cys Cys Gln Arg Ser Glu Asn Pro Thr Gly 
                 325                330                335
Pro Thr Glu Ser Ser Asp Arg Ser Ala Ser Ser Leu Asn His Thr Ile 
             340                345                350
Leu Ala Gly Val His Ser Asn Asp His Ser Val Val 
         355                360



<210> 4848
<211> 581
<212> DNA
<213> Rattus norvegicus
<308> AA849038
<400> 4848

ggaggcaat  ctgtaactt  atttgacat  cagcagtta  ttctcatcc  cattgaccg  60
ctgtagatt  ttgaatgtg  taacaggca  gtaagttac  agtgtgtag  gcttgtttg  120
tgaatcctc  tcctcatta  gctttctgg  caaacgtac  cggatgcgg  acggaacat  180
ccttattcc  ttggcccag  cggctttat  gagcctggt  tctatgcgc  catctggag  240
tcccatctc  ttcatggca  atttccgaa  ttctttgag  gcccgagga  cacgcttct  300
gaagcccac  ccatggatg  gtttgtgaa  gttgatggt  tattctcgg  tcaccacct  360
gttgatggc  gaacggccc  tcttcttct  gccaccctt  tttgcggga  ccatctaaa  420
gcagggata  ggaggttta  gcaggcagt  ggaaagtcc  ggctaaggt  acctcggca  480
gctgttctc  caccgcccc  gaccgcaga  aaatcacac  gagcttgcc  gccccgcgc  540
cggagcgga  ggagccgga  ttcagagcc  cgaccccgc  a  581



<210> 4849
<211> 125
<212> PRT
<213> Rattus norvegicus
<308> P12947
<400> 4849

Met Ala Pro Ala Lys Lys Gly Gly Glu Lys Lys Lys Gly Arg Ser Ala 
  1               5                  10                  15
Ile Asn Glu Val Val Thr Arg Glu Tyr Thr Ile Asn Ile His Lys Arg 
             20                  25                  30
Ile His Gly Val Gly Phe Lys Lys Arg Ala Pro Arg Ala Leu Lys Glu 
         35                  40                  45
Ile Arg Lys Phe Ala Met Lys Glu Met Gly Thr Pro Asp Val Arg Ile 
     50                  55                  60
Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Asn Val 
 65                  70                  75                  80
Pro Tyr Arg Ile Arg Val Arg Leu Ser Arg Lys Arg Asn Glu Asp Glu 
                 85                  90                  95
Asp Ser Pro Asn Lys Leu Tyr Thr Leu Val Thr Tyr Val Pro Val Thr 
             100                105                110
Thr Phe Lys Asn Leu Gln Thr Val Asn Val Asp Glu Asn 
         115                120                125



<210> 4850
<211> 806
<212> DNA
<213> Homo sapiens
<308> BC001663
<400> 4850

ggcacgagg  cagaatggc  cccgcaaag  agggtggcg  gaagaaaaa  ggccgttct  60
ccatcaacg  agtggtaac  cgagaatac  ccatcaaca  tcacaagcg  atccatgga  120
tgggcttca  gaagcgtgc  cctcgggca  tcaaagaga  tcggaaatt  gccatgaag  180
agatgggaa  tccagatgt  cgcattgac  ccaggctca  caaagctgt  tgggccaaa  240
gaataaggt  ctaaagtta  ctgtattcg  aggtgaact  ttgcaatga  accagcttc  300
cttaaccct  caagagccc  tatcagaat  tgccatacc  aatccgtgt  cggctgtcc  360
gaaaacgta  tgaggatga  gattcacca  ataagctat  tactttggt  acctatgta  420
ctgttacca  tttcaaaag  aagttctcc  tcccataaa  ccatttaaa  tcattagaa  480
aatgtcctt  cctcttaaa  tgtgaattc  tctgttaag  taggggtga  acacgtcat  540
gtacccttt  taaattgtt  gtgtgggaa  atgctaaag  atgcaaaac  gatccatat  600
tgggatgta  aaaggttgt  gaaaataga  tgtccagac  cgtctacaa  aggttttta  660
agttgaaat  tgaaatgtg  tgtgggtat  gaaattgac  gttacttcc  ttacagatc  720
acagacagt  aatgtggat  agaactaat  gctgatcgt  agatcaaat  aagttataa  780
attgccttc  aaaaaaaaa  aaaaaa  806



<210> 4851
<211> 125
<212> PRT
<213> Homo sapiens
<308> NP_000984
<400> 4851

Met Ala Pro Ala Lys Lys Gly Gly Glu Lys Lys Lys Gly Arg Ser Ala 
  1               5                  10                  15
Ile Asn Glu Val Val Thr Arg Glu Tyr Thr Ile Asn Ile His Lys Arg 
             20                  25                  30
Ile His Gly Val Gly Phe Lys Lys Arg Ala Pro Arg Ala Leu Lys Glu 
         35                  40                  45
Ile Arg Lys Phe Ala Met Lys Glu Met Gly Thr Pro Asp Val Arg Ile 
     50                  55                  60
Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Asn Val 
 65                  70                  75                  80
Pro Tyr Arg Ile Arg Val Arg Leu Ser Arg Lys Arg Asn Glu Asp Glu 
                 85                  90                  95
Asp Ser Pro Asn Lys Leu Tyr Thr Leu Val Thr Tyr Val Pro Val Thr 
             100                105                110
Thr Phe Lys Asn Leu Gln Thr Val Asn Val Asp Glu Asn 
         115                120                125



<210> 4852
<211> 413
<212> DNA
<213> Rattus norvegicus
<308> AA849648
<400> 4852

aagtagagg  ggggtactc  gtatatgtt  tctagacct  ttaggaaac  tggagtcgt  60
cctttggcc  catacatgc  aatctacaa  aagggtgat  ttgtagaca  caagggaat  120
ggcactgtt  aaaaaggaa  gccccataa  tgttaccat  gcaaaaccg  aagagtcta  180
aatgtcacc  agcatgccg  gggcatcat  gtgaacaag  aagttaaag  caagattct  240
gccaagagg  tcaatgtgc  gattgagca  atcaagcac  caaagagca  agacagctt  300
ctgaagcgg  tgaaggaga  cgatcagaa  aaaaaggaa  ccaaagaga  aggcacctg  360
gttcagctg  agcgccaga  tgcgccacc  agagagacc  actttgtga  gac  413



<210> 4853
<211> 159
<212> PRT
<213> Rattus norvegicus
<308> P20280
<400> 4853

Thr Asn Thr Lys Gly Lys Arg Arg Gly Thr Arg Tyr Met Phe Ser Arg 
  1               5                  10                  15
Pro Phe Arg Lys His Gly Val Val Pro Leu Ala Thr Tyr Met Arg Ile 
             20                  25                  30
Tyr Lys Lys Gly Asp Ile Val Asp Ile Lys Gly Met Gly Thr Val Gln 
         35                  40                  45
Lys Gly Met Pro His Lys Cys Tyr His Gly Lys Thr Gly Arg Val Tyr 
     50                  55                  60
Asn Val Thr Gln His Ala Val Gly Ile Ile Val Asn Lys Gln Val Lys 
 65                  70                  75                  80
Gly Lys Ile Leu Ala Lys Arg Ile Asn Val Arg Ile Glu His Ile Lys 
                 85                  90                  95
His Ser Lys Ser Arg Asp Ser Phe Leu Lys Arg Val Lys Glu Asn Asp 
             100                105                110
Gln Lys Lys Lys Glu Ala Lys Glu Lys Gly Thr Trp Val Gln Leu Asn 
         115                120                125
Gly Gln Pro Ala Pro Pro Arg Glu Ala His Phe Val Arg Thr Asn Gly 
     130                135                140
Lys Glu Pro Glu Leu Leu Glu Pro Ile Pro Tyr Glu Phe Met Ala 
 145                150                155



<210> 4854
<211> 2458
<212> DNA
<213> Homo sapiens
<308> X04790
<400> 4854

tgacccaat  agggtggaa  gctgagtcc  gcagagcca  taacgagag  ccgagaggc  60
acggaggcg  actctgtga  gaaacaaga  gagaggccc  agatggaga  ggcggcggc  120
gtagcggcg  gacaggagc  ccatggcac  tgcccagcc  cacctcagc  catcttgac  180
aaatctaag  ctccatgga  ccaccacgg  gcccccctg  caatggggc  gagccatcc  240
gggcagtgg  caccgtcaa  gtatacctg  ccaacaagc  acgcacggt  gtgactgtc  300
gggatggca  gagtgtcta  gactctcta  acaaggccc  gaaggtgcg  ggtctaaat  360
aggactgct  tgtggtcta  cgactcatc  agggacgaa  gacggtcac  gcctgggac  420
cagccattg  tcccctgga  ggcgaggag  tcattgtcg  ggtccttga  gatgtcccg  480
tgaccatgc  caattttgt  cggaagacc  tcttcagcc  ggcgttctg  gacttctgc  540
ttaagtttc  gttccatgg  ttccgttgc  aaacctgtg  ctacaagtt  caccagcat  600
gttcctcca  ggtccccac  gtctgtgtt  acatgagta  caaccgcca  cagttctac  660
acagtgtcc  ggatttgtc  ggaggctcc  gacagcatg  ggctccctc  aaccgcccc  720
tgaatgagt  gctaacccc  cagggtccc  gcccccgca  ccagcactg  gacccggag  780
acttcccct  ccctgcccc  gccaatgcc  ccctacagc  catccgctc  acgtccact  840
ccaacgtcc  tatggtcag  accacggcc  ccatggact  caacctcat  cagctcact  900
gccagagtt  cagcactga  gctgccggt  gtagaggag  tagtgatgg  accccccgg  960
ggagcccca  cccagccag  gtgtcctcg  ggaggaagt  cccacattc  aagtcacca  1020
cagagcagc  cgagcggaa  tccttggcc  atgacaaga  gaaagtgaa  aacctgggg  1080
accgggant  aggctatta  tgggaggta  cacccagtg  ggtgcagct  ctgaagagg  1140
tcgggacgg  ctcgtttgg  accgtgttt  gagggcggt  gcatggcga  gtggccgtg  1200
aggtgctca  ggtgtccca  cccacagct  agcaggccc  ggctttcaa  aatgagatg  1260
aggtgctca  gaagacgcg  catgtcaac  tcttgctgt  tatgggctt  atgacccgg  1320
cgggatttg  catcatcac  cagtggtgt  agggctcca  cctctacca  cacctgcat  1380
tggccgaca  acgcttcga  atggtccag  tcatcgacg  ggcccggca  actgcccag  1440
gcatggact  cctccatgc  aagaacatc  tccaccgag  tctcaagtc  aacaacatc  1500
tcctacatg  ggggctcac  gtgaagatc  gtgactttg  cttggccac  gtgaagact  1560
gatggagcg  ggcccagcc  ttggagcag  cctcaggat  tgtgctgtg  atggcagct  1620
aggtgatcc  tatgcagga  ccgaacccc  acagcttcc  gtcagacgt  tatgcctac  1680
gggttgtgc  ctacgagct  atgactggc  cactgcctt  cagccacat  ggctgccgt  1740
accagatta  ctttatggt  ggccgtggc  atctgtccc  ggacctcag  aaaatctcc  1800
gcaactgcc  caaggccat  cggcgcctg  tgtctgact  cctcaagtt  cagcgggag  1860
agcggcccc  cttccccca  atcctggcc  caattgagc  gctgcaacg  tcactcccc  1920
agattgagc  gagtgcctc  gaaccctcc  tgcaccgca  ccaggccga  gagttgcct  1980
cctgcctac  cagcgcagc  cgccttgtg  cttaggccc  gcccaagcc  ccagggagc  2040
aatctcagc  ctccacgcc  aggagcctt  cccaccagc  aatcaatgt  cgtctctgc  2100
ctgatgctg  ctcaggatc  cccattccc  accctggga  atgaggggg  ccccatgtg  2160
ttttccagt  cttctggaa  tgggggacc  ccgccaaag  ctgagcccc  tgtctcctc  2220
atcatttgg  ttcctcttg  ctttgggga  acttctaaa  tttgggagc  cctccatct  2280
caatggctg  gatttgtgg  agggattcc  ctcagaacc  ctctggaat  tgtgcctga  2340
gtgccttcc  ctggatttt  gggttccca  caccccatg  ggattttgg  gggtccctt  2400
tgtgtctcc  ccgccattc  aggactcct  tctttcttc  ccaagaagc  cagaattc  2458



<210> 4855
<211> 606
<212> PRT
<213> Homo sapiens
<308> P10398
<400> 4855

Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
  1               5                  10                  15
Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val 
             20                  25                  30
Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
         35                  40                  45
Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
     50                  55                  60
Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro 
 65                  70                  75                  80
Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                 85                  90                  95
Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys 
             100                105                110
Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys 
         115                120                125
Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys 
     130                135                140
Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp 
 145                150                155                160
Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu 
                 165                170                175
Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr Gln His Cys 
             180                185                190
Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala Pro Leu Gln 
         195                200                205
Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr 
     210                215                220
Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln Ser Phe Ser 
 225                230                235                240
Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr Pro Arg Gly 
                 245                250                255
Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser 
             260                265                270
Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Asp Lys 
         275                280                285
Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr Tyr Trp Glu 
     290                295                300
Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Thr Gly Ser 
 305                310                315                320
Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys 
                 325                330                335
Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln Ala Phe Lys 
             340                345                350
Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu 
         355                360                365
Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile Thr Gln Trp 
     370                375                380
Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Thr Arg 
 385                390                395                400
Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr Ala Gln Gly 
                 405                410                415
Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser 
             420                425                430
Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile Gly Asp Phe 
         435                440                445
Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln Pro Leu Glu 
     450                455                460
Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met 
 465                470                475                480
Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly 
                 485                490                495
Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr Ser His Ile 
             500                505                510
Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser 
         515                520                525
Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala Met Arg Arg 
     530                535                540
Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe 
 545                550                555                560
Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys 
                 565                570                575
Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr Gln Ala Asp 
             580                585                590
Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro 
         595                600                605



<210> 4856
<211> 413
<212> DNA
<213> Rattus norvegicus
<308> AA849648
<400> 4856

aagtagagg  ggggtactc  gtatatgtt  tctagacct  ttaggaaac  tggagtcgt  60
cctttggcc  catacatgc  aatctacaa  aagggtgat  ttgtagaca  caagggaat  120
ggcactgtt  aaaaaggaa  gccccataa  tgttaccat  gcaaaaccg  aagagtcta  180
aatgtcacc  agcatgccg  gggcatcat  gtgaacaag  aagttaaag  caagattct  240
gccaagagg  tcaatgtgc  gattgagca  atcaagcac  caaagagca  agacagctt  300
ctgaagcgg  tgaaggaga  cgatcagaa  aaaaaggaa  ccaaagaga  aggcacctg  360
gttcagctg  agcgccaga  tgcgccacc  agagagacc  actttgtga  gac  413



<210> 4857
<211> 159
<212> PRT
<213> Rattus norvegicus
<308> P20280
<400> 4857

Thr Asn Thr Lys Gly Lys Arg Arg Gly Thr Arg Tyr Met Phe Ser Arg 
  1               5                  10                  15
Pro Phe Arg Lys His Gly Val Val Pro Leu Ala Thr Tyr Met Arg Ile 
             20                  25                  30
Tyr Lys Lys Gly Asp Ile Val Asp Ile Lys Gly Met Gly Thr Val Gln 
         35                  40                  45
Lys Gly Met Pro His Lys Cys Tyr His Gly Lys Thr Gly Arg Val Tyr 
     50                  55                  60
Asn Val Thr Gln His Ala Val Gly Ile Ile Val Asn Lys Gln Val Lys 
 65                  70                  75                  80
Gly Lys Ile Leu Ala Lys Arg Ile Asn Val Arg Ile Glu His Ile Lys 
                 85                  90                  95
His Ser Lys Ser Arg Asp Ser Phe Leu Lys Arg Val Lys Glu Asn Asp 
             100                105                110
Gln Lys Lys Lys Glu Ala Lys Glu Lys Gly Thr Trp Val Gln Leu Asn 
         115                120                125
Gly Gln Pro Ala Pro Pro Arg Glu Ala His Phe Val Arg Thr Asn Gly 
     130                135                140
Lys Glu Pro Glu Leu Leu Glu Pro Ile Pro Tyr Glu Phe Met Ala 
 145                150                155



<210> 4858
<211> 2458
<212> DNA
<213> Homo sapiens
<308> X04790
<400> 4858

tgacccaat  agggtggaa  gctgagtcc  gcagagcca  taacgagag  ccgagaggc  60
acggaggcg  actctgtga  gaaacaaga  gagaggccc  agatggaga  ggcggcggc  120
gtagcggcg  gacaggagc  ccatggcac  tgcccagcc  cacctcagc  catcttgac  180
aaatctaag  ctccatgga  ccaccacgg  gcccccctg  caatggggc  gagccatcc  240
gggcagtgg  caccgtcaa  gtatacctg  ccaacaagc  acgcacggt  gtgactgtc  300
gggatggca  gagtgtcta  gactctcta  acaaggccc  gaaggtgcg  ggtctaaat  360
aggactgct  tgtggtcta  cgactcatc  agggacgaa  gacggtcac  gcctgggac  420
cagccattg  tcccctgga  ggcgaggag  tcattgtcg  ggtccttga  gatgtcccg  480
tgaccatgc  caattttgt  cggaagacc  tcttcagcc  ggcgttctg  gacttctgc  540
ttaagtttc  gttccatgg  ttccgttgc  aaacctgtg  ctacaagtt  caccagcat  600
gttcctcca  ggtccccac  gtctgtgtt  acatgagta  caaccgcca  cagttctac  660
acagtgtcc  ggatttgtc  ggaggctcc  gacagcatg  ggctccctc  aaccgcccc  720
tgaatgagt  gctaacccc  cagggtccc  gcccccgca  ccagcactg  gacccggag  780
acttcccct  ccctgcccc  gccaatgcc  ccctacagc  catccgctc  acgtccact  840
ccaacgtcc  tatggtcag  accacggcc  ccatggact  caacctcat  cagctcact  900
gccagagtt  cagcactga  gctgccggt  gtagaggag  tagtgatgg  accccccgg  960
ggagcccca  cccagccag  gtgtcctcg  ggaggaagt  cccacattc  aagtcacca  1020
cagagcagc  cgagcggaa  tccttggcc  atgacaaga  gaaagtgaa  aacctgggg  1080
accgggant  aggctatta  tgggaggta  cacccagtg  ggtgcagct  ctgaagagg  1140
tcgggacgg  ctcgtttgg  accgtgttt  gagggcggt  gcatggcga  gtggccgtg  1200
aggtgctca  ggtgtccca  cccacagct  agcaggccc  ggctttcaa  aatgagatg  1260
aggtgctca  gaagacgcg  catgtcaac  tcttgctgt  tatgggctt  atgacccgg  1320
cgggatttg  catcatcac  cagtggtgt  agggctcca  cctctacca  cacctgcat  1380
tggccgaca  acgcttcga  atggtccag  tcatcgacg  ggcccggca  actgcccag  1440
gcatggact  cctccatgc  aagaacatc  tccaccgag  tctcaagtc  aacaacatc  1500
tcctacatg  ggggctcac  gtgaagatc  gtgactttg  cttggccac  gtgaagact  1560
gatggagcg  ggcccagcc  ttggagcag  cctcaggat  tgtgctgtg  atggcagct  1620
aggtgatcc  tatgcagga  ccgaacccc  acagcttcc  gtcagacgt  tatgcctac  1680
gggttgtgc  ctacgagct  atgactggc  cactgcctt  cagccacat  ggctgccgt  1740
accagatta  ctttatggt  ggccgtggc  atctgtccc  ggacctcag  aaaatctcc  1800
gcaactgcc  caaggccat  cggcgcctg  tgtctgact  cctcaagtt  cagcgggag  1860
agcggcccc  cttccccca  atcctggcc  caattgagc  gctgcaacg  tcactcccc  1920
agattgagc  gagtgcctc  gaaccctcc  tgcaccgca  ccaggccga  gagttgcct  1980
cctgcctac  cagcgcagc  cgccttgtg  cttaggccc  gcccaagcc  ccagggagc  2040
aatctcagc  ctccacgcc  aggagcctt  cccaccagc  aatcaatgt  cgtctctgc  2100
ctgatgctg  ctcaggatc  cccattccc  accctggga  atgaggggg  ccccatgtg  2160
ttttccagt  cttctggaa  tgggggacc  ccgccaaag  ctgagcccc  tgtctcctc  2220
atcatttgg  ttcctcttg  ctttgggga  acttctaaa  tttgggagc  cctccatct  2280
caatggctg  gatttgtgg  agggattcc  ctcagaacc  ctctggaat  tgtgcctga  2340
gtgccttcc  ctggatttt  gggttccca  caccccatg  ggattttgg  gggtccctt  2400
tgtgtctcc  ccgccattc  aggactcct  tctttcttc  ccaagaagc  cagaattc  2458



<210> 4859
<211> 606
<212> PRT
<213> Homo sapiens
<308> P10398
<400> 4859

Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
  1               5                  10                  15
Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val 
             20                  25                  30
Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
         35                  40                  45
Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
     50                  55                  60
Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro 
 65                  70                  75                  80
Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                 85                  90                  95
Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys 
             100                105                110
Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys 
         115                120                125
Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys 
     130                135                140
Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp 
 145                150                155                160
Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu 
                 165                170                175
Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr Gln His Cys 
             180                185                190
Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala Pro Leu Gln 
         195                200                205
Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr 
     210                215                220
Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln Ser Phe Ser 
 225                230                235                240
Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr Pro Arg Gly 
                 245                250                255
Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser 
             260                265                270
Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Asp Lys 
         275                280                285
Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr Tyr Trp Glu 
     290                295                300
Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Thr Gly Ser 
 305                310                315                320
Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys 
                 325                330                335
Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln Ala Phe Lys 
             340                345                350
Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu 
         355                360                365
Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile Thr Gln Trp 
     370                375                380
Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Thr Arg 
 385                390                395                400
Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr Ala Gln Gly 
                 405                410                415
Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser 
             420                425                430
Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile Gly Asp Phe 
         435                440                445
Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln Pro Leu Glu 
     450                455                460
Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met 
 465                470                475                480
Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly 
                 485                490                495
Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr Ser His Ile 
             500                505                510
Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser 
         515                520                525
Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala Met Arg Arg 
     530                535                540
Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe 
 545                550                555                560
Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys 
                 565                570                575
Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr Gln Ala Asp 
             580                585                590
Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro 
         595                600                605



<210> 4860
<211> 413
<212> DNA
<213> Rattus norvegicus
<308> AA849648
<400> 4860

aagtagagg  ggggtactc  gtatatgtt  tctagacct  ttaggaaac  tggagtcgt  60
cctttggcc  catacatgc  aatctacaa  aagggtgat  ttgtagaca  caagggaat  120
ggcactgtt  aaaaaggaa  gccccataa  tgttaccat  gcaaaaccg  aagagtcta  180
aatgtcacc  agcatgccg  gggcatcat  gtgaacaag  aagttaaag  caagattct  240
gccaagagg  tcaatgtgc  gattgagca  atcaagcac  caaagagca  agacagctt  300
ctgaagcgg  tgaaggaga  cgatcagaa  aaaaaggaa  ccaaagaga  aggcacctg  360
gttcagctg  agcgccaga  tgcgccacc  agagagacc  actttgtga  gac  413



<210> 4861
<211> 159
<212> PRT
<213> Rattus norvegicus
<308> P20280
<400> 4861

Thr Asn Thr Lys Gly Lys Arg Arg Gly Thr Arg Tyr Met Phe Ser Arg 
  1               5                  10                  15
Pro Phe Arg Lys His Gly Val Val Pro Leu Ala Thr Tyr Met Arg Ile 
             20                  25                  30
Tyr Lys Lys Gly Asp Ile Val Asp Ile Lys Gly Met Gly Thr Val Gln 
         35                  40                  45
Lys Gly Met Pro His Lys Cys Tyr His Gly Lys Thr Gly Arg Val Tyr 
     50                  55                  60
Asn Val Thr Gln His Ala Val Gly Ile Ile Val Asn Lys Gln Val Lys 
 65                  70                  75                  80
Gly Lys Ile Leu Ala Lys Arg Ile Asn Val Arg Ile Glu His Ile Lys 
                 85                  90                  95
His Ser Lys Ser Arg Asp Ser Phe Leu Lys Arg Val Lys Glu Asn Asp 
             100                105                110
Gln Lys Lys Lys Glu Ala Lys Glu Lys Gly Thr Trp Val Gln Leu Asn 
         115                120                125
Gly Gln Pro Ala Pro Pro Arg Glu Ala His Phe Val Arg Thr Asn Gly 
     130                135                140
Lys Glu Pro Glu Leu Leu Glu Pro Ile Pro Tyr Glu Phe Met Ala 
 145                150                155



<210> 4862
<211> 2458
<212> DNA
<213> Homo sapiens
<308> X04790
<400> 4862

tgacccaat  agggtggaa  gctgagtcc  gcagagcca  taacgagag  ccgagaggc  60
acggaggcg  actctgtga  gaaacaaga  gagaggccc  agatggaga  ggcggcggc  120
gtagcggcg  gacaggagc  ccatggcac  tgcccagcc  cacctcagc  catcttgac  180
aaatctaag  ctccatgga  ccaccacgg  gcccccctg  caatggggc  gagccatcc  240
gggcagtgg  caccgtcaa  gtatacctg  ccaacaagc  acgcacggt  gtgactgtc  300
gggatggca  gagtgtcta  gactctcta  acaaggccc  gaaggtgcg  ggtctaaat  360
aggactgct  tgtggtcta  cgactcatc  agggacgaa  gacggtcac  gcctgggac  420
cagccattg  tcccctgga  ggcgaggag  tcattgtcg  ggtccttga  gatgtcccg  480
tgaccatgc  caattttgt  cggaagacc  tcttcagcc  ggcgttctg  gacttctgc  540
ttaagtttc  gttccatgg  ttccgttgc  aaacctgtg  ctacaagtt  caccagcat  600
gttcctcca  ggtccccac  gtctgtgtt  acatgagta  caaccgcca  cagttctac  660
acagtgtcc  ggatttgtc  ggaggctcc  gacagcatg  ggctccctc  aaccgcccc  720
tgaatgagt  gctaacccc  cagggtccc  gcccccgca  ccagcactg  gacccggag  780
acttcccct  ccctgcccc  gccaatgcc  ccctacagc  catccgctc  acgtccact  840
ccaacgtcc  tatggtcag  accacggcc  ccatggact  caacctcat  cagctcact  900
gccagagtt  cagcactga  gctgccggt  gtagaggag  tagtgatgg  accccccgg  960
ggagcccca  cccagccag  gtgtcctcg  ggaggaagt  cccacattc  aagtcacca  1020
cagagcagc  cgagcggaa  tccttggcc  atgacaaga  gaaagtgaa  aacctgggg  1080
accgggant  aggctatta  tgggaggta  cacccagtg  ggtgcagct  ctgaagagg  1140
tcgggacgg  ctcgtttgg  accgtgttt  gagggcggt  gcatggcga  gtggccgtg  1200
aggtgctca  ggtgtccca  cccacagct  agcaggccc  ggctttcaa  aatgagatg  1260
aggtgctca  gaagacgcg  catgtcaac  tcttgctgt  tatgggctt  atgacccgg  1320
cgggatttg  catcatcac  cagtggtgt  agggctcca  cctctacca  cacctgcat  1380
tggccgaca  acgcttcga  atggtccag  tcatcgacg  ggcccggca  actgcccag  1440
gcatggact  cctccatgc  aagaacatc  tccaccgag  tctcaagtc  aacaacatc  1500
tcctacatg  ggggctcac  gtgaagatc  gtgactttg  cttggccac  gtgaagact  1560
gatggagcg  ggcccagcc  ttggagcag  cctcaggat  tgtgctgtg  atggcagct  1620
aggtgatcc  tatgcagga  ccgaacccc  acagcttcc  gtcagacgt  tatgcctac  1680
gggttgtgc  ctacgagct  atgactggc  cactgcctt  cagccacat  ggctgccgt  1740
accagatta  ctttatggt  ggccgtggc  atctgtccc  ggacctcag  aaaatctcc  1800
gcaactgcc  caaggccat  cggcgcctg  tgtctgact  cctcaagtt  cagcgggag  1860
agcggcccc  cttccccca  atcctggcc  caattgagc  gctgcaacg  tcactcccc  1920
agattgagc  gagtgcctc  gaaccctcc  tgcaccgca  ccaggccga  gagttgcct  1980
cctgcctac  cagcgcagc  cgccttgtg  cttaggccc  gcccaagcc  ccagggagc  2040
aatctcagc  ctccacgcc  aggagcctt  cccaccagc  aatcaatgt  cgtctctgc  2100
ctgatgctg  ctcaggatc  cccattccc  accctggga  atgaggggg  ccccatgtg  2160
ttttccagt  cttctggaa  tgggggacc  ccgccaaag  ctgagcccc  tgtctcctc  2220
atcatttgg  ttcctcttg  ctttgggga  acttctaaa  tttgggagc  cctccatct  2280
caatggctg  gatttgtgg  agggattcc  ctcagaacc  ctctggaat  tgtgcctga  2340
gtgccttcc  ctggatttt  gggttccca  caccccatg  ggattttgg  gggtccctt  2400
tgtgtctcc  ccgccattc  aggactcct  tctttcttc  ccaagaagc  cagaattc  2458



<210> 4863
<211> 606
<212> PRT
<213> Homo sapiens
<308> P10398
<400> 4863

Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
  1               5                  10                  15
Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val 
             20                  25                  30
Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
         35                  40                  45
Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
     50                  55                  60
Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro 
 65                  70                  75                  80
Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                 85                  90                  95
Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys 
             100                105                110
Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys 
         115                120                125
Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys 
     130                135                140
Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp 
 145                150                155                160
Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu 
                 165                170                175
Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr Gln His Cys 
             180                185                190
Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala Pro Leu Gln 
         195                200                205
Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr 
     210                215                220
Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln Ser Phe Ser 
 225                230                235                240
Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr Pro Arg Gly 
                 245                250                255
Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser 
             260                265                270
Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Asp Lys 
         275                280                285
Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr Tyr Trp Glu 
     290                295                300
Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Thr Gly Ser 
 305                310                315                320
Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys 
                 325                330                335
Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln Ala Phe Lys 
             340                345                350
Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu 
         355                360                365
Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile Thr Gln Trp 
     370                375                380
Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Thr Arg 
 385                390                395                400
Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr Ala Gln Gly 
                 405                410                415
Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser 
             420                425                430
Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile Gly Asp Phe 
         435                440                445
Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln Pro Leu Glu 
     450                455                460
Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met 
 465                470                475                480
Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly 
                 485                490                495
Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr Ser His Ile 
             500                505                510
Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser 
         515                520                525
Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala Met Arg Arg 
     530                535                540
Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe 
 545                550                555                560
Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys 
                 565                570                575
Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr Gln Ala Asp 
             580                585                590
Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro 
         595                600                605



<210> 4864
<211> 413
<212> DNA
<213> Rattus norvegicus
<308> AA849648
<400> 4864

aagtagagg  ggggtactc  gtatatgtt  tctagacct  ttaggaaac  tggagtcgt  60
cctttggcc  catacatgc  aatctacaa  aagggtgat  ttgtagaca  caagggaat  120
ggcactgtt  aaaaaggaa  gccccataa  tgttaccat  gcaaaaccg  aagagtcta  180
aatgtcacc  agcatgccg  gggcatcat  gtgaacaag  aagttaaag  caagattct  240
gccaagagg  tcaatgtgc  gattgagca  atcaagcac  caaagagca  agacagctt  300
ctgaagcgg  tgaaggaga  cgatcagaa  aaaaaggaa  ccaaagaga  aggcacctg  360
gttcagctg  agcgccaga  tgcgccacc  agagagacc  actttgtga  gac  413



<210> 4865
<211> 159
<212> PRT
<213> Rattus norvegicus
<308> P20280
<400> 4865

Thr Asn Thr Lys Gly Lys Arg Arg Gly Thr Arg Tyr Met Phe Ser Arg 
  1               5                  10                  15
Pro Phe Arg Lys His Gly Val Val Pro Leu Ala Thr Tyr Met Arg Ile 
             20                  25                  30
Tyr Lys Lys Gly Asp Ile Val Asp Ile Lys Gly Met Gly Thr Val Gln 
         35                  40                  45
Lys Gly Met Pro His Lys Cys Tyr His Gly Lys Thr Gly Arg Val Tyr 
     50                  55                  60
Asn Val Thr Gln His Ala Val Gly Ile Ile Val Asn Lys Gln Val Lys 
 65                  70                  75                  80
Gly Lys Ile Leu Ala Lys Arg Ile Asn Val Arg Ile Glu His Ile Lys 
                 85                  90                  95
His Ser Lys Ser Arg Asp Ser Phe Leu Lys Arg Val Lys Glu Asn Asp 
             100                105                110
Gln Lys Lys Lys Glu Ala Lys Glu Lys Gly Thr Trp Val Gln Leu Asn 
         115                120                125
Gly Gln Pro Ala Pro Pro Arg Glu Ala His Phe Val Arg Thr Asn Gly 
     130                135                140
Lys Glu Pro Glu Leu Leu Glu Pro Ile Pro Tyr Glu Phe Met Ala 
 145                150                155



<210> 4866
<211> 2458
<212> DNA
<213> Homo sapiens
<308> X04790
<400> 4866

tgacccaat  agggtggaa  gctgagtcc  gcagagcca  taacgagag  ccgagaggc  60
acggaggcg  actctgtga  gaaacaaga  gagaggccc  agatggaga  ggcggcggc  120
gtagcggcg  gacaggagc  ccatggcac  tgcccagcc  cacctcagc  catcttgac  180
aaatctaag  ctccatgga  ccaccacgg  gcccccctg  caatggggc  gagccatcc  240
gggcagtgg  caccgtcaa  gtatacctg  ccaacaagc  acgcacggt  gtgactgtc  300
gggatggca  gagtgtcta  gactctcta  acaaggccc  gaaggtgcg  ggtctaaat  360
aggactgct  tgtggtcta  cgactcatc  agggacgaa  gacggtcac  gcctgggac  420
cagccattg  tcccctgga  ggcgaggag  tcattgtcg  ggtccttga  gatgtcccg  480
tgaccatgc  caattttgt  cggaagacc  tcttcagcc  ggcgttctg  gacttctgc  540
ttaagtttc  gttccatgg  ttccgttgc  aaacctgtg  ctacaagtt  caccagcat  600
gttcctcca  ggtccccac  gtctgtgtt  acatgagta  caaccgcca  cagttctac  660
acagtgtcc  ggatttgtc  ggaggctcc  gacagcatg  ggctccctc  aaccgcccc  720
tgaatgagt  gctaacccc  cagggtccc  gcccccgca  ccagcactg  gacccggag  780
acttcccct  ccctgcccc  gccaatgcc  ccctacagc  catccgctc  acgtccact  840
ccaacgtcc  tatggtcag  accacggcc  ccatggact  caacctcat  cagctcact  900
gccagagtt  cagcactga  gctgccggt  gtagaggag  tagtgatgg  accccccgg  960
ggagcccca  cccagccag  gtgtcctcg  ggaggaagt  cccacattc  aagtcacca  1020
cagagcagc  cgagcggaa  tccttggcc  atgacaaga  gaaagtgaa  aacctgggg  1080
accgggant  aggctatta  tgggaggta  cacccagtg  ggtgcagct  ctgaagagg  1140
tcgggacgg  ctcgtttgg  accgtgttt  gagggcggt  gcatggcga  gtggccgtg  1200
aggtgctca  ggtgtccca  cccacagct  agcaggccc  ggctttcaa  aatgagatg  1260
aggtgctca  gaagacgcg  catgtcaac  tcttgctgt  tatgggctt  atgacccgg  1320
cgggatttg  catcatcac  cagtggtgt  agggctcca  cctctacca  cacctgcat  1380
tggccgaca  acgcttcga  atggtccag  tcatcgacg  ggcccggca  actgcccag  1440
gcatggact  cctccatgc  aagaacatc  tccaccgag  tctcaagtc  aacaacatc  1500
tcctacatg  ggggctcac  gtgaagatc  gtgactttg  cttggccac  gtgaagact  1560
gatggagcg  ggcccagcc  ttggagcag  cctcaggat  tgtgctgtg  atggcagct  1620
aggtgatcc  tatgcagga  ccgaacccc  acagcttcc  gtcagacgt  tatgcctac  1680
gggttgtgc  ctacgagct  atgactggc  cactgcctt  cagccacat  ggctgccgt  1740
accagatta  ctttatggt  ggccgtggc  atctgtccc  ggacctcag  aaaatctcc  1800
gcaactgcc  caaggccat  cggcgcctg  tgtctgact  cctcaagtt  cagcgggag  1860
agcggcccc  cttccccca  atcctggcc  caattgagc  gctgcaacg  tcactcccc  1920
agattgagc  gagtgcctc  gaaccctcc  tgcaccgca  ccaggccga  gagttgcct  1980
cctgcctac  cagcgcagc  cgccttgtg  cttaggccc  gcccaagcc  ccagggagc  2040
aatctcagc  ctccacgcc  aggagcctt  cccaccagc  aatcaatgt  cgtctctgc  2100
ctgatgctg  ctcaggatc  cccattccc  accctggga  atgaggggg  ccccatgtg  2160
ttttccagt  cttctggaa  tgggggacc  ccgccaaag  ctgagcccc  tgtctcctc  2220
atcatttgg  ttcctcttg  ctttgggga  acttctaaa  tttgggagc  cctccatct  2280
caatggctg  gatttgtgg  agggattcc  ctcagaacc  ctctggaat  tgtgcctga  2340
gtgccttcc  ctggatttt  gggttccca  caccccatg  ggattttgg  gggtccctt  2400
tgtgtctcc  ccgccattc  aggactcct  tctttcttc  ccaagaagc  cagaattc  2458



<210> 4867
<211> 606
<212> PRT
<213> Homo sapiens
<308> P10398
<400> 4867

Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
  1               5                  10                  15
Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val 
             20                  25                  30
Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
         35                  40                  45
Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
     50                  55                  60
Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro 
 65                  70                  75                  80
Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                 85                  90                  95
Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys 
             100                105                110
Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys 
         115                120                125
Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys 
     130                135                140
Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp 
 145                150                155                160
Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu 
                 165                170                175
Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr Gln His Cys 
             180                185                190
Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala Pro Leu Gln 
         195                200                205
Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr 
     210                215                220
Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln Ser Phe Ser 
 225                230                235                240
Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr Pro Arg Gly 
                 245                250                255
Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser 
             260                265                270
Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Asp Lys 
         275                280                285
Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr Tyr Trp Glu 
     290                295                300
Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Thr Gly Ser 
 305                310                315                320
Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys 
                 325                330                335
Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln Ala Phe Lys 
             340                345                350
Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu 
         355                360                365
Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile Thr Gln Trp 
     370                375                380
Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Thr Arg 
 385                390                395                400
Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr Ala Gln Gly 
                 405                410                415
Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser 
             420                425                430
Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile Gly Asp Phe 
         435                440                445
Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln Pro Leu Glu 
     450                455                460
Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met 
 465                470                475                480
Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly 
                 485                490                495
Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr Ser His Ile 
             500                505                510
Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser 
         515                520                525
Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala Met Arg Arg 
     530                535                540
Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe 
 545                550                555                560
Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys 
                 565                570                575
Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr Gln Ala Asp 
             580                585                590
Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro 
         595                600                605



<210> 4868
<211> 608
<212> DNA
<213> Rattus norvegicus
<308> AA849769
<400> 4868

acgtccaat  cacataaaa  aggacaaca  aggggcttg  ggattgcct  aaccacaaa  60
taccattga  taaatctca  gatgcctcc  aatcagttc  ctaaggaaa  ggacaccca  120
aaataggag  gctaggacc  cagtgactc  ctctgcccg  tagccacag  tgacggcag  180
ctgccatgg  ctgggatcc  gtccttgga  cttctcaca  gaaatgaaa  caaatcaac  240
ctttggtaa  aaaaaaaaa  aagaaggga  atgtattta  aattttggt  aggtctcca  300
ggcgcttga  gtccgtaag  atttgcatc  ttcaaaccc  ctcttcagg  aactccaag  360
ttgagggac  cagctaact  atggggcga  tgtgtatgc  ggtgactgt  gggatcaaa  420
ggagaagca  atttgctgc  gatctggga  gatgacagt  gtgacaagg  tcaaagcag  480
agggttcct  cccaccaag  tccccctat  tcctccagc  gggccagct  agtgttccc  540
ctaacatca  atgcttttc  tgttgtatc  tcacagctg  ccccagaaa  gtttcattc  600
nacctgcc  608



<210> 4869
<211> 306
<212> PRT
<213> Rattus norvegicus
<308> Q62632
<400> 4869

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Val Thr Ile Ala Leu Val 
  1               5                  10                  15
His Gly Glu Glu Glu Gln Arg Ser Lys Ser Lys Ile Cys Ala Asn Val 
             20                  25                  30
Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly Glu Pro 
         35                  40                  45
Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro Val Cys 
     50                  55                  60
Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His Arg Asp 
 65                  70                  75                  80
Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly His Cys 
                 85                  90                  95
Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val Cys Tyr 
             100                105                110
Gln Ala Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp Leu Glu 
         115                120                125
Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn Tyr Ser 
     130                135                140
Glu Ile Leu Asp Lys Tyr Phe Lys Ser Phe Asp Asn Gly Asp Ser His 
 145                150                155                160
Leu Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu Thr Ala 
                 165                170                175
Val Asn Ile Thr Ala Tyr Pro Asn Gln Glu Asn Asn Lys Leu Leu Arg 
             180                185                190
Gly Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn Ala Asp 
         195                200                205
Trp Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro Ser Phe 
     210                215                220
Asn Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr Ala Asp 
 225                230                235                240
Gly Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ser Cys Gly 
                 245                250                255
His Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln Lys Gly 
             260                265                270
Val Gln Thr His Thr Glu Glu Glu Met Thr Arg Tyr Ala Gln Glu Leu 
         275                280                285
Gln Lys His Gln Gly Thr Ala Glu Lys Thr Lys Lys Val Asn Thr Lys 
     290                295                300
Glu Ile 
 305



<210> 4870
<211> 1987
<212> DNA
<213> Homo sapiens
<308> U06863
<400> 4870

gggcggggc  atcggcgga  ctcccacct  cgcttacag  tcgctgccg  cgtcctgcc  60
cgcgccccc  ggagacctg  accagacca  gatgtggaa  cgctggctc  cgctcgcgc  120
cgcgctggt  gcggtcgcc  gggtccgcg  cgaggaaga  ctaaggagc  aatccaaga  180
ctgtgccaa  gtgttttgt  gagccggcc  ggaatgtgc  gtcacagag  aaggggaac  240
cacctgtct  tgcattgag  aatgcaaac  tcacaagag  cctgtgtgt  gcagtaatg  300
caagaccta  ctcaaccac  gtgaactgc  tcgagatgc  tgcctcact  gatccaaaa  360
ccaggttga  tacgatgga  actgcaaag  gaagaaatc  gtaagtcca  ctgccagcc  420
agttgtttg  tatcagtcc  accgtgatg  gctccgacg  cgcatcatc  agtggctgg  480
agctgagat  attccagat  gctggttct  taaaggcag  aactacagt  aaatcctag  540
caagtattt  aagaacttt  ataatggtg  ttctcgcct  gactccagt  aattcctga  600
gtttgtgga  cagaatgaa  ctgccatca  tattacaac  tatccagac  aggagaaca  660
caagttgct  aggggactc  gtgttgatg  tctcattga  ctgtctgat  aaaatgctg  720
ttggaaact  agcttccaa  agtttctca  gtgcctcaa  ccatctttc  accctcctg  780
gaagaagtg  gccctggag  atgaaacgt  tgcagatgg  gctgagacc  aggtggact  840
taaccgctg  gtctgtgcc  gtggaaatt  ggtctgtac  gccatgacc  gtgacggaa  900
gaatcagaa  ggggcccag  cccagacag  ggaggagat  accagatat  tccaggagc  960
ccaaaagca  caggaaaca  ctgaaaaga  caagagagt  agcaccaaa  agatctaat  1020
aggaggcac  gaccagtgt  tggatccca  catcttctc  acttcagcg  tgagttcag  1080
atacacaag  gtctgctac  gtcgccaaa  caccagtat  tgcttatat  gcaatgagt  1140
ttattttgt  tatttgttt  gcaataaag  atatgaagg  ggctggcta  gaagggaag  1200
gccacagcc  tcatttcta  gagtgcttt  agagaaact  taaatggtg  tctggggct  1260
gaggctagt  aggaaactg  atcacgatt  aaagaggaa  agacccaaa  ctgaacctc  1320
tttgagttt  ctgcatctg  cagcaggct  cagggagtg  acacgatgc  agagagaac  1380
tagcagggt  tccccggag  agaggtttg  gaagctcca  ggagaggaa  gctctctgc  1440
tccagcctc  ttccattgc  gtcagcatg  cagacctcc  gcatccacg  atctcttgg  1500
cccaataac  gcctctaga  acatagcca  actgctagt  aacccagtg  ccctcagac  1560
tggatggag  ttctgggag  gtacaccca  atgatgcag  tacttgtat  ctttgagcc  1620
cttagcgac  taaccaaat  ttaaaaata  tttttacca  aggtgctat  tctctgtaa  1680
acacttttt  tggcaagtt  actttattc  tcaattatt  tcattatat  attgttttt  1740
aatatttta  tttcttgac  aggtattaa  cttttgtaa  tatttttca  tagtcccac  1800
acttcatag  tggaaggag  ttggggttc  tcctggtgc  ggggctgaa  taacccaga  1860
gcccccacc  tgccacata  tagatgcag  ccatagttg  cccccctag  ttccagcag  1920
ccactatct  ccagaggag  aagggtgcc  tagaccgaa  ccaggggaa  aagcatcct  1980
gctcccc  1987



<210> 4871
<211> 308
<212> PRT
<213> Homo sapiens
<308> Q12841
<400> 4871

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
  1               5                  10                  15
Trp Val Arg Ala Glu Glu Glu Leu Arg Ser Lys Ser Lys Ile Cys Ala 
             20                  25                  30
Asn Val Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly 
         35                  40                  45
Glu Pro Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro 
     50                  55                  60
Val Cys Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His 
 65                  70                  75                  80
Arg Asp Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly 
                 85                  90                  95
His Cys Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val 
             100                105                110
Cys Tyr Gln Ser Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp 
         115                120                125
Leu Glu Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn 
     130                135                140
Tyr Ser Glu Ile Leu Asp Lys Tyr Phe Lys Asn Phe Asp Asn Gly Asp 
 145                150                155                160
Ser Arg Leu Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu 
                 165                170                175
Thr Ala Ile Asn Ile Thr Thr Tyr Pro Asp Gln Glu Asn Asn Lys Leu 
             180                185                190
Leu Arg Gly Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn 
         195                200                205
Ala Asp Trp Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro 
     210                215                220
Ser Phe Asn Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr 
 225                230                235                240
Ala Asp Gly Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ala 
                 245                250                255
Cys Gly Asn Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln 
             260                265                270
Lys Gly Ala Gln Thr Gln Thr Glu Glu Glu Met Thr Arg Tyr Val Gln 
         275                280                285
Glu Leu Gln Lys His Gln Glu Thr Ala Glu Lys Thr Lys Arg Val Ser 
     290                295                300
Thr Lys Glu Ile 
 305



<210> 4872
<211> 608
<212> DNA
<213> Rattus norvegicus
<308> AA849769
<400> 4872

acgtccaat  cacataaaa  aggacaaca  aggggcttg  ggattgcct  aaccacaaa  60
taccattga  taaatctca  gatgcctcc  aatcagttc  ctaaggaaa  ggacaccca  120
aaataggag  gctaggacc  cagtgactc  ctctgcccg  tagccacag  tgacggcag  180
ctgccatgg  ctgggatcc  gtccttgga  cttctcaca  gaaatgaaa  caaatcaac  240
ctttggtaa  aaaaaaaaa  aagaaggga  atgtattta  aattttggt  aggtctcca  300
ggcgcttga  gtccgtaag  atttgcatc  ttcaaaccc  ctcttcagg  aactccaag  360
ttgagggac  cagctaact  atggggcga  tgtgtatgc  ggtgactgt  gggatcaaa  420
ggagaagca  atttgctgc  gatctggga  gatgacagt  gtgacaagg  tcaaagcag  480
agggttcct  cccaccaag  tccccctat  tcctccagc  gggccagct  agtgttccc  540
ctaacatca  atgcttttc  tgttgtatc  tcacagctg  ccccagaaa  gtttcattc  600
nacctgcc  608



<210> 4873
<211> 306
<212> PRT
<213> Rattus norvegicus
<308> Q62632
<400> 4873

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Val Thr Ile Ala Leu Val 
  1               5                  10                  15
His Gly Glu Glu Glu Gln Arg Ser Lys Ser Lys Ile Cys Ala Asn Val 
             20                  25                  30
Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly Glu Pro 
         35                  40                  45
Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro Val Cys 
     50                  55                  60
Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His Arg Asp 
 65                  70                  75                  80
Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly His Cys 
                 85                  90                  95
Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val Cys Tyr 
             100                105                110
Gln Ala Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp Leu Glu 
         115                120                125
Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn Tyr Ser 
     130                135                140
Glu Ile Leu Asp Lys Tyr Phe Lys Ser Phe Asp Asn Gly Asp Ser His 
 145                150                155                160
Leu Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu Thr Ala 
                 165                170                175
Val Asn Ile Thr Ala Tyr Pro Asn Gln Glu Asn Asn Lys Leu Leu Arg 
             180                185                190
Gly Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn Ala Asp 
         195                200                205
Trp Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro Ser Phe 
     210                215                220
Asn Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr Ala Asp 
 225                230                235                240
Gly Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ser Cys Gly 
                 245                250                255
His Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln Lys Gly 
             260                265                270
Val Gln Thr His Thr Glu Glu Glu Met Thr Arg Tyr Ala Gln Glu Leu 
         275                280                285
Gln Lys His Gln Gly Thr Ala Glu Lys Thr Lys Lys Val Asn Thr Lys 
     290                295                300
Glu Ile 
 305



<210> 4874
<211> 1987
<212> DNA
<213> Homo sapiens
<308> U06863
<400> 4874

gggcggggc  atcggcgga  ctcccacct  cgcttacag  tcgctgccg  cgtcctgcc  60
cgcgccccc  ggagacctg  accagacca  gatgtggaa  cgctggctc  cgctcgcgc  120
cgcgctggt  gcggtcgcc  gggtccgcg  cgaggaaga  ctaaggagc  aatccaaga  180
ctgtgccaa  gtgttttgt  gagccggcc  ggaatgtgc  gtcacagag  aaggggaac  240
cacctgtct  tgcattgag  aatgcaaac  tcacaagag  cctgtgtgt  gcagtaatg  300
caagaccta  ctcaaccac  gtgaactgc  tcgagatgc  tgcctcact  gatccaaaa  360
ccaggttga  tacgatgga  actgcaaag  gaagaaatc  gtaagtcca  ctgccagcc  420
agttgtttg  tatcagtcc  accgtgatg  gctccgacg  cgcatcatc  agtggctgg  480
agctgagat  attccagat  gctggttct  taaaggcag  aactacagt  aaatcctag  540
caagtattt  aagaacttt  ataatggtg  ttctcgcct  gactccagt  aattcctga  600
gtttgtgga  cagaatgaa  ctgccatca  tattacaac  tatccagac  aggagaaca  660
caagttgct  aggggactc  gtgttgatg  tctcattga  ctgtctgat  aaaatgctg  720
ttggaaact  agcttccaa  agtttctca  gtgcctcaa  ccatctttc  accctcctg  780
gaagaagtg  gccctggag  atgaaacgt  tgcagatgg  gctgagacc  aggtggact  840
taaccgctg  gtctgtgcc  gtggaaatt  ggtctgtac  gccatgacc  gtgacggaa  900
gaatcagaa  ggggcccag  cccagacag  ggaggagat  accagatat  tccaggagc  960
ccaaaagca  caggaaaca  ctgaaaaga  caagagagt  agcaccaaa  agatctaat  1020
aggaggcac  gaccagtgt  tggatccca  catcttctc  acttcagcg  tgagttcag  1080
atacacaag  gtctgctac  gtcgccaaa  caccagtat  tgcttatat  gcaatgagt  1140
ttattttgt  tatttgttt  gcaataaag  atatgaagg  ggctggcta  gaagggaag  1200
gccacagcc  tcatttcta  gagtgcttt  agagaaact  taaatggtg  tctggggct  1260
gaggctagt  aggaaactg  atcacgatt  aaagaggaa  agacccaaa  ctgaacctc  1320
tttgagttt  ctgcatctg  cagcaggct  cagggagtg  acacgatgc  agagagaac  1380
tagcagggt  tccccggag  agaggtttg  gaagctcca  ggagaggaa  gctctctgc  1440
tccagcctc  ttccattgc  gtcagcatg  cagacctcc  gcatccacg  atctcttgg  1500
cccaataac  gcctctaga  acatagcca  actgctagt  aacccagtg  ccctcagac  1560
tggatggag  ttctgggag  gtacaccca  atgatgcag  tacttgtat  ctttgagcc  1620
cttagcgac  taaccaaat  ttaaaaata  tttttacca  aggtgctat  tctctgtaa  1680
acacttttt  tggcaagtt  actttattc  tcaattatt  tcattatat  attgttttt  1740
aatatttta  tttcttgac  aggtattaa  cttttgtaa  tatttttca  tagtcccac  1800
acttcatag  tggaaggag  ttggggttc  tcctggtgc  ggggctgaa  taacccaga  1860
gcccccacc  tgccacata  tagatgcag  ccatagttg  cccccctag  ttccagcag  1920
ccactatct  ccagaggag  aagggtgcc  tagaccgaa  ccaggggaa  aagcatcct  1980
gctcccc  1987



<210> 4875
<211> 308
<212> PRT
<213> Homo sapiens
<308> Q12841
<400> 4875

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
  1               5                  10                  15
Trp Val Arg Ala Glu Glu Glu Leu Arg Ser Lys Ser Lys Ile Cys Ala 
             20                  25                  30
Asn Val Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly 
         35                  40                  45
Glu Pro Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro 
     50                  55                  60
Val Cys Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His 
 65                  70                  75                  80
Arg Asp Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly 
                 85                  90                  95
His Cys Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val 
             100                105                110
Cys Tyr Gln Ser Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp 
         115                120                125
Leu Glu Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn 
     130                135                140
Tyr Ser Glu Ile Leu Asp Lys Tyr Phe Lys Asn Phe Asp Asn Gly Asp 
 145                150                155                160
Ser Arg Leu Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu 
                 165                170                175
Thr Ala Ile Asn Ile Thr Thr Tyr Pro Asp Gln Glu Asn Asn Lys Leu 
             180                185                190
Leu Arg Gly Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn 
         195                200                205
Ala Asp Trp Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro 
     210                215                220
Ser Phe Asn Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr 
 225                230                235                240
Ala Asp Gly Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ala 
                 245                250                255
Cys Gly Asn Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln 
             260                265                270
Lys Gly Ala Gln Thr Gln Thr Glu Glu Glu Met Thr Arg Tyr Val Gln 
         275                280                285
Glu Leu Gln Lys His Gln Glu Thr Ala Glu Lys Thr Lys Arg Val Ser 
     290                295                300
Thr Lys Glu Ile 
 305



<210> 4876
<211> 608
<212> DNA
<213> Rattus norvegicus
<308> AA849769
<400> 4876

acgtccaat  cacataaaa  aggacaaca  aggggcttg  ggattgcct  aaccacaaa  60
taccattga  taaatctca  gatgcctcc  aatcagttc  ctaaggaaa  ggacaccca  120
aaataggag  gctaggacc  cagtgactc  ctctgcccg  tagccacag  tgacggcag  180
ctgccatgg  ctgggatcc  gtccttgga  cttctcaca  gaaatgaaa  caaatcaac  240
ctttggtaa  aaaaaaaaa  aagaaggga  atgtattta  aattttggt  aggtctcca  300
ggcgcttga  gtccgtaag  atttgcatc  ttcaaaccc  ctcttcagg  aactccaag  360
ttgagggac  cagctaact  atggggcga  tgtgtatgc  ggtgactgt  gggatcaaa  420
ggagaagca  atttgctgc  gatctggga  gatgacagt  gtgacaagg  tcaaagcag  480
agggttcct  cccaccaag  tccccctat  tcctccagc  gggccagct  agtgttccc  540
ctaacatca  atgcttttc  tgttgtatc  tcacagctg  ccccagaaa  gtttcattc  600
nacctgcc  608



<210> 4877
<211> 306
<212> PRT
<213> Rattus norvegicus
<308> Q62632
<400> 4877

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Val Thr Ile Ala Leu Val 
  1               5                  10                  15
His Gly Glu Glu Glu Gln Arg Ser Lys Ser Lys Ile Cys Ala Asn Val 
             20                  25                  30
Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly Glu Pro 
         35                  40                  45
Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro Val Cys 
     50                  55                  60
Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His Arg Asp 
 65                  70                  75                  80
Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly His Cys 
                 85                  90                  95
Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val Cys Tyr 
             100                105                110
Gln Ala Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp Leu Glu 
         115                120                125
Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn Tyr Ser 
     130                135                140
Glu Ile Leu Asp Lys Tyr Phe Lys Ser Phe Asp Asn Gly Asp Ser His 
 145                150                155                160
Leu Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu Thr Ala 
                 165                170                175
Val Asn Ile Thr Ala Tyr Pro Asn Gln Glu Asn Asn Lys Leu Leu Arg 
             180                185                190
Gly Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn Ala Asp 
         195                200                205
Trp Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro Ser Phe 
     210                215                220
Asn Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr Ala Asp 
 225                230                235                240
Gly Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ser Cys Gly 
                 245                250                255
His Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln Lys Gly 
             260                265                270
Val Gln Thr His Thr Glu Glu Glu Met Thr Arg Tyr Ala Gln Glu Leu 
         275                280                285
Gln Lys His Gln Gly Thr Ala Glu Lys Thr Lys Lys Val Asn Thr Lys 
     290                295                300
Glu Ile 
 305



<210> 4878
<211> 1987
<212> DNA
<213> Homo sapiens
<308> U06863
<400> 4878

gggcggggc  atcggcgga  ctcccacct  cgcttacag  tcgctgccg  cgtcctgcc  60
cgcgccccc  ggagacctg  accagacca  gatgtggaa  cgctggctc  cgctcgcgc  120
cgcgctggt  gcggtcgcc  gggtccgcg  cgaggaaga  ctaaggagc  aatccaaga  180
ctgtgccaa  gtgttttgt  gagccggcc  ggaatgtgc  gtcacagag  aaggggaac  240
cacctgtct  tgcattgag  aatgcaaac  tcacaagag  cctgtgtgt  gcagtaatg  300
caagaccta  ctcaaccac  gtgaactgc  tcgagatgc  tgcctcact  gatccaaaa  360
ccaggttga  tacgatgga  actgcaaag  gaagaaatc  gtaagtcca  ctgccagcc  420
agttgtttg  tatcagtcc  accgtgatg  gctccgacg  cgcatcatc  agtggctgg  480
agctgagat  attccagat  gctggttct  taaaggcag  aactacagt  aaatcctag  540
caagtattt  aagaacttt  ataatggtg  ttctcgcct  gactccagt  aattcctga  600
gtttgtgga  cagaatgaa  ctgccatca  tattacaac  tatccagac  aggagaaca  660
caagttgct  aggggactc  gtgttgatg  tctcattga  ctgtctgat  aaaatgctg  720
ttggaaact  agcttccaa  agtttctca  gtgcctcaa  ccatctttc  accctcctg  780
gaagaagtg  gccctggag  atgaaacgt  tgcagatgg  gctgagacc  aggtggact  840
taaccgctg  gtctgtgcc  gtggaaatt  ggtctgtac  gccatgacc  gtgacggaa  900
gaatcagaa  ggggcccag  cccagacag  ggaggagat  accagatat  tccaggagc  960
ccaaaagca  caggaaaca  ctgaaaaga  caagagagt  agcaccaaa  agatctaat  1020
aggaggcac  gaccagtgt  tggatccca  catcttctc  acttcagcg  tgagttcag  1080
atacacaag  gtctgctac  gtcgccaaa  caccagtat  tgcttatat  gcaatgagt  1140
ttattttgt  tatttgttt  gcaataaag  atatgaagg  ggctggcta  gaagggaag  1200
gccacagcc  tcatttcta  gagtgcttt  agagaaact  taaatggtg  tctggggct  1260
gaggctagt  aggaaactg  atcacgatt  aaagaggaa  agacccaaa  ctgaacctc  1320
tttgagttt  ctgcatctg  cagcaggct  cagggagtg  acacgatgc  agagagaac  1380
tagcagggt  tccccggag  agaggtttg  gaagctcca  ggagaggaa  gctctctgc  1440
tccagcctc  ttccattgc  gtcagcatg  cagacctcc  gcatccacg  atctcttgg  1500
cccaataac  gcctctaga  acatagcca  actgctagt  aacccagtg  ccctcagac  1560
tggatggag  ttctgggag  gtacaccca  atgatgcag  tacttgtat  ctttgagcc  1620
cttagcgac  taaccaaat  ttaaaaata  tttttacca  aggtgctat  tctctgtaa  1680
acacttttt  tggcaagtt  actttattc  tcaattatt  tcattatat  attgttttt  1740
aatatttta  tttcttgac  aggtattaa  cttttgtaa  tatttttca  tagtcccac  1800
acttcatag  tggaaggag  ttggggttc  tcctggtgc  ggggctgaa  taacccaga  1860
gcccccacc  tgccacata  tagatgcag  ccatagttg  cccccctag  ttccagcag  1920
ccactatct  ccagaggag  aagggtgcc  tagaccgaa  ccaggggaa  aagcatcct  1980
gctcccc  1987



<210> 4879
<211> 308
<212> PRT
<213> Homo sapiens
<308> Q12841
<400> 4879

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
  1               5                  10                  15
Trp Val Arg Ala Glu Glu Glu Leu Arg Ser Lys Ser Lys Ile Cys Ala 
             20                  25                  30
Asn Val Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly 
         35                  40                  45
Glu Pro Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro 
     50                  55                  60
Val Cys Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His 
 65                  70                  75                  80
Arg Asp Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly 
                 85                  90                  95
His Cys Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val 
             100                105                110
Cys Tyr Gln Ser Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp 
         115                120                125
Leu Glu Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn 
     130                135                140
Tyr Ser Glu Ile Leu Asp Lys Tyr Phe Lys Asn Phe Asp Asn Gly Asp 
 145                150                155                160
Ser Arg Leu Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu 
                 165                170                175
Thr Ala Ile Asn Ile Thr Thr Tyr Pro Asp Gln Glu Asn Asn Lys Leu 
             180                185                190
Leu Arg Gly Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn 
         195                200                205
Ala Asp Trp Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro 
     210                215                220
Ser Phe Asn Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr 
 225                230                235                240
Ala Asp Gly Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ala 
                 245                250                255
Cys Gly Asn Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln 
             260                265                270
Lys Gly Ala Gln Thr Gln Thr Glu Glu Glu Met Thr Arg Tyr Val Gln 
         275                280                285
Glu Leu Gln Lys His Gln Glu Thr Ala Glu Lys Thr Lys Arg Val Ser 
     290                295                300
Thr Lys Glu Ile 
 305



<210> 4880
<211> 608
<212> DNA
<213> Rattus norvegicus
<308> AA849769
<400> 4880

acgtccaat  cacataaaa  aggacaaca  aggggcttg  ggattgcct  aaccacaaa  60
taccattga  taaatctca  gatgcctcc  aatcagttc  ctaaggaaa  ggacaccca  120
aaataggag  gctaggacc  cagtgactc  ctctgcccg  tagccacag  tgacggcag  180
ctgccatgg  ctgggatcc  gtccttgga  cttctcaca  gaaatgaaa  caaatcaac  240
ctttggtaa  aaaaaaaaa  aagaaggga  atgtattta  aattttggt  aggtctcca  300
ggcgcttga  gtccgtaag  atttgcatc  ttcaaaccc  ctcttcagg  aactccaag  360
ttgagggac  cagctaact  atggggcga  tgtgtatgc  ggtgactgt  gggatcaaa  420
ggagaagca  atttgctgc  gatctggga  gatgacagt  gtgacaagg  tcaaagcag  480
agggttcct  cccaccaag  tccccctat  tcctccagc  gggccagct  agtgttccc  540
ctaacatca  atgcttttc  tgttgtatc  tcacagctg  ccccagaaa  gtttcattc  600
nacctgcc  608



<210> 4881
<211> 306
<212> PRT
<213> Rattus norvegicus
<308> Q62632
<400> 4881

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Val Thr Ile Ala Leu Val 
  1               5                  10                  15
His Gly Glu Glu Glu Gln Arg Ser Lys Ser Lys Ile Cys Ala Asn Val 
             20                  25                  30
Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly Glu Pro 
         35                  40                  45
Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro Val Cys 
     50                  55                  60
Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His Arg Asp 
 65                  70                  75                  80
Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly His Cys 
                 85                  90                  95
Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val Cys Tyr 
             100                105                110
Gln Ala Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp Leu Glu 
         115                120                125
Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn Tyr Ser 
     130                135                140
Glu Ile Leu Asp Lys Tyr Phe Lys Ser Phe Asp Asn Gly Asp Ser His 
 145                150                155                160
Leu Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu Thr Ala 
                 165                170                175
Val Asn Ile Thr Ala Tyr Pro Asn Gln Glu Asn Asn Lys Leu Leu Arg 
             180                185                190
Gly Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn Ala Asp 
         195                200                205
Trp Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro Ser Phe 
     210                215                220
Asn Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr Ala Asp 
 225                230                235                240
Gly Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ser Cys Gly 
                 245                250                255
His Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln Lys Gly 
             260                265                270
Val Gln Thr His Thr Glu Glu Glu Met Thr Arg Tyr Ala Gln Glu Leu 
         275                280                285
Gln Lys His Gln Gly Thr Ala Glu Lys Thr Lys Lys Val Asn Thr Lys 
     290                295                300
Glu Ile 
 305



<210> 4882
<211> 1987
<212> DNA
<213> Homo sapiens
<308> U06863
<400> 4882

gggcggggc  atcggcgga  ctcccacct  cgcttacag  tcgctgccg  cgtcctgcc  60
cgcgccccc  ggagacctg  accagacca  gatgtggaa  cgctggctc  cgctcgcgc  120
cgcgctggt  gcggtcgcc  gggtccgcg  cgaggaaga  ctaaggagc  aatccaaga  180
ctgtgccaa  gtgttttgt  gagccggcc  ggaatgtgc  gtcacagag  aaggggaac  240
cacctgtct  tgcattgag  aatgcaaac  tcacaagag  cctgtgtgt  gcagtaatg  300
caagaccta  ctcaaccac  gtgaactgc  tcgagatgc  tgcctcact  gatccaaaa  360
ccaggttga  tacgatgga  actgcaaag  gaagaaatc  gtaagtcca  ctgccagcc  420
agttgtttg  tatcagtcc  accgtgatg  gctccgacg  cgcatcatc  agtggctgg  480
agctgagat  attccagat  gctggttct  taaaggcag  aactacagt  aaatcctag  540
caagtattt  aagaacttt  ataatggtg  ttctcgcct  gactccagt  aattcctga  600
gtttgtgga  cagaatgaa  ctgccatca  tattacaac  tatccagac  aggagaaca  660
caagttgct  aggggactc  gtgttgatg  tctcattga  ctgtctgat  aaaatgctg  720
ttggaaact  agcttccaa  agtttctca  gtgcctcaa  ccatctttc  accctcctg  780
gaagaagtg  gccctggag  atgaaacgt  tgcagatgg  gctgagacc  aggtggact  840
taaccgctg  gtctgtgcc  gtggaaatt  ggtctgtac  gccatgacc  gtgacggaa  900
gaatcagaa  ggggcccag  cccagacag  ggaggagat  accagatat  tccaggagc  960
ccaaaagca  caggaaaca  ctgaaaaga  caagagagt  agcaccaaa  agatctaat  1020
aggaggcac  gaccagtgt  tggatccca  catcttctc  acttcagcg  tgagttcag  1080
atacacaag  gtctgctac  gtcgccaaa  caccagtat  tgcttatat  gcaatgagt  1140
ttattttgt  tatttgttt  gcaataaag  atatgaagg  ggctggcta  gaagggaag  1200
gccacagcc  tcatttcta  gagtgcttt  agagaaact  taaatggtg  tctggggct  1260
gaggctagt  aggaaactg  atcacgatt  aaagaggaa  agacccaaa  ctgaacctc  1320
tttgagttt  ctgcatctg  cagcaggct  cagggagtg  acacgatgc  agagagaac  1380
tagcagggt  tccccggag  agaggtttg  gaagctcca  ggagaggaa  gctctctgc  1440
tccagcctc  ttccattgc  gtcagcatg  cagacctcc  gcatccacg  atctcttgg  1500
cccaataac  gcctctaga  acatagcca  actgctagt  aacccagtg  ccctcagac  1560
tggatggag  ttctgggag  gtacaccca  atgatgcag  tacttgtat  ctttgagcc  1620
cttagcgac  taaccaaat  ttaaaaata  tttttacca  aggtgctat  tctctgtaa  1680
acacttttt  tggcaagtt  actttattc  tcaattatt  tcattatat  attgttttt  1740
aatatttta  tttcttgac  aggtattaa  cttttgtaa  tatttttca  tagtcccac  1800
acttcatag  tggaaggag  ttggggttc  tcctggtgc  ggggctgaa  taacccaga  1860
gcccccacc  tgccacata  tagatgcag  ccatagttg  cccccctag  ttccagcag  1920
ccactatct  ccagaggag  aagggtgcc  tagaccgaa  ccaggggaa  aagcatcct  1980
gctcccc  1987



<210> 4883
<211> 308
<212> PRT
<213> Homo sapiens
<308> Q12841
<400> 4883

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
  1               5                  10                  15
Trp Val Arg Ala Glu Glu Glu Leu Arg Ser Lys Ser Lys Ile Cys Ala 
             20                  25                  30
Asn Val Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly 
         35                  40                  45
Glu Pro Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro 
     50                  55                  60
Val Cys Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His 
 65                  70                  75                  80
Arg Asp Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly 
                 85                  90                  95
His Cys Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val 
             100                105                110
Cys Tyr Gln Ser Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp 
         115                120                125
Leu Glu Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn 
     130                135                140
Tyr Ser Glu Ile Leu Asp Lys Tyr Phe Lys Asn Phe Asp Asn Gly Asp 
 145                150                155                160
Ser Arg Leu Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu 
                 165                170                175
Thr Ala Ile Asn Ile Thr Thr Tyr Pro Asp Gln Glu Asn Asn Lys Leu 
             180                185                190
Leu Arg Gly Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn 
         195                200                205
Ala Asp Trp Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro 
     210                215                220
Ser Phe Asn Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr 
 225                230                235                240
Ala Asp Gly Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ala 
                 245                250                255
Cys Gly Asn Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln 
             260                265                270
Lys Gly Ala Gln Thr Gln Thr Glu Glu Glu Met Thr Arg Tyr Val Gln 
         275                280                285
Glu Leu Gln Lys His Gln Glu Thr Ala Glu Lys Thr Lys Arg Val Ser 
     290                295                300
Thr Lys Glu Ile 
 305



<210> 4884
<211> 474
<212> DNA
<213> Rattus norvegicus
<308> AA850138
<400> 4884

tgggcaagg  agaagggat  aggtagcta  tagagagaa  agaccctgc  ctgggtcta  60
agctgcagg  ttcccaggc  aaggagaaa  ctgggctcc  agacacatt  tgcaggaga  120
agactcttc  ccacagtgt  cccttcatg  gtaacttgg  aggtaaaac  gttgcgaga  180
ctccactgt  ctgctgtca  acgtaagaa  ctgctggcg  tgtatttgt  gccctgttt  240
gtgggattt  cagtgtcca  accctggga  ataggtgca  catttgcct  ccaggccac  300
tccacatca  tcgggtaga  atcagaaat  agacacacc  gtgtggctt  gtttccctg  360
agctcctca  ttgaaggtg  aaatactgt  agtgtggga  tggacttgg  ctgacctag  420
acagtgagc  tggttccac  gccgaaaat  taccacagt  actgagact  aatc  474



<210> 4885
<211> 104
<212> PRT
<213> Rattus norvegicus
<308> B27390
<400> 4885

Gln Pro Lys Ser Thr Pro Thr Leu Thr Val Phe Pro Pro Ser Thr Glu 
  1               5                  10                  15
Glu Leu Gln Gly Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
             20                  25                  30
Tyr Pro Ser Asp Val Glu Val Ala Trp Lys Ala Asn Gly Ala Pro Ile 
         35                  40                  45
Ser Gln Gly Val Asp Thr Ala Asn Pro Thr Lys Gln Gly Asn Lys Tyr 
     50                  55                  60
Ile Ala Ser Ser Phe Leu Arg Leu Thr Ala Glu Gln Trp Arg Ser Arg 
 65                  70                  75                  80
Asn Ser Phe Thr Cys Gln Val Thr His Glu Gly Asn Thr Val Glu Lys 
                 85                  90                  95
Ser Leu Ser Pro Ala Glu Cys Val 
             100



<210> 4886
<211> 1053
<212> DNA
<213> Homo sapiens
<308> AJ318022
<400> 4886

agccggctg  ggtgggagg  agttgagcc  tggattgtg  ccgcttcag  gcagttggt  60
gatgcccct  tgggagaga  ccccagggg  gacagccat  gaccctgga  gggcctggg  120
tagggacag  gaccagagc  agtccaggg  gaggacaga  ccaatggac  ggggtgtac  180
gtaacagcc  tgctggcga  agggaccag  gcaccgtcc  ccagggagc  catgctgca  240
gtcgggcca  aggtgcccc  gaacctgaa  gccaatgag  cccaagaca  gccaagtgg  300
ttgtgagac  cctgaggag  tgggccctg  tcccaggca  cgctggccc  tgctgctgc  360
gggtctggc  atggtcgcc  atggcctgc  gcgcccaat  gttgcaccg  aaagcggcg  420
cccagaccc  ggagcctca  ttggaagca  ccgatccag  ctgcggagc  tgtggggca  480
gctcctgct  cagcccagc  cccagagag  agaccccag  tgctggccc  gggggtttt  540
gtctgagcc  cagtcactg  gttatgtct  cggaactgg  accaaggtc  ccgtcctag  600
tcagcccaa  gccaacccc  ctgtcactc  gttcccgcc  tcctctgag  agctccaag  660
caacaaggc  acactagtg  gtctgatca  tgacttcta  ccgggagct  tgacagtgg  720
ctggaaggc  gatggcagc  ccgtcaagg  gggagtgga  accaccaaa  cctccaaac  780
gagcaacaa  aagtacgcg  ccagcagct  cctgagcct  acgcccgag  agtggaagt  840
ccacagaag  tacagctgc  aggtcacgc  tgaagggag  accgtggag  agacagtgg  900
ccctacaga  tgttcatag  ttcccaact  taaccccac  cacgggagc  tggagctgc  960
ggatcccag  ggaggggac  tctctctcc  catcccaag  catccagcc  ttctccctg  1020
actcatgaa  ccccaataa  tatcctcat  gac  1053



<210> 4887
<211> 105
<212> PRT
<213> Homo sapiens
<308> P01842
<400> 4887

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
  1               5                  10                  15
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
             20                  25                  30
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
         35                  40                  45
Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
     50                  55                  60
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
 65                  70                  75                  80
His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                 85                  90                  95
Lys Thr Val Ala Pro Thr Glu Cys Ser 
             100                105



<210> 4888
<211> 477
<212> DNA
<213> Rattus norvegicus
<308> AA850734
<400> 4888

gggtgggtg  gtctacagg  atcccagaa  caaaactcc  taatcttcc  ggcttggcg  60
tttagcagc  aatataaga  aatggcgaa  ccagttcca  gagggacca  cgtgcttgg  120
cacctgccc  ggaatgcgt  tgccggagt  tcgccctcc  gacccaaag  gctcctcga  180
gagtctcct  tcccttcat  tcaggcttt  tggattaag  actgttctg  cgacggtga  240
gatggtggt  tggtggtga  atggttaat  ggtctttcc  gtgagaggt  tagttcccg  300
aaccctgag  gaggctcct  cctgcagcc  ggctcaccg  cttggcttg  cacatctgc  360
agtacgttc  tttaactca  gctgcctcg  cttgcaacg  gagtctgtg  ttttgcagg  420
acatttaca  gtctgcgga  cttggacaa  caaatgctt  ctccgctct  aacaagg  477



<210> 4889
<211> 214
<212> PRT
<213> Rattus norvegicus
<308> P16612
<400> 4889

Met Asn Phe Leu Leu Ser Trp Val His Trp Thr Leu Ala Leu Leu Leu 
  1               5                  10                  15
Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Thr Thr Glu Gly 
             20                  25                  30
Glu Gln Lys Ala His Glu Val Val Lys Phe Met Asp Val Tyr Gln Arg 
         35                  40                  45
Ser Tyr Cys Arg Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu Tyr 
     50                  55                  60
Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu Met 
 65                  70                  75                  80
Arg Cys Ala Gly Cys Cys Asn Asp Glu Ala Leu Glu Cys Val Pro Thr 
                 85                  90                  95
Ser Glu Ser Asn Val Thr Met Gln Ile Met Arg Ile Lys Pro His Gln 
             100                105                110
Ser Gln His Ile Gly Glu Met Ser Phe Leu Gln His Ser Arg Cys Glu 
         115                120                125
Cys Arg Pro Lys Lys Asp Arg Thr Lys Pro Glu Lys Lys Ser Val Arg 
     130                135                140
Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Phe Lys 
 145                150                155                160
Ser Trp Ser Val His Cys Glu Pro Cys Ser Glu Arg Arg Lys His Leu 
                 165                170                175
Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp 
             180                185                190
Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg 
         195                200                205
Cys Asp Lys Pro Arg Arg 
     210



<210> 4890
<211> 550
<212> DNA
<213> Rattus norvegicus
<308> AA850781
<400> 4890

tttttttta  cacttacaa  caattttat  gagacagag  catacctgc  ggtttatac  60
cataattgt  acaggttac  tccttctca  ccttctgag  gctacaacc  tttagtgcc  120
ttcatgacc  caaacataa  tttattctt  tgctacttt  gaactgtga  tttgctact  180
ttctgaacc  taagtaaaa  tatctgtgt  ttccagtgg  cccacagat  gaggactac  240
gggctagaa  gtcctctta  aatctaaac  ttggccaga  accactctt  gtgaaaatg  300
agacagaaa  actttataa  gagattcac  gtaattcgt  actttatta  ggaaccgat  360
tcagcactg  tatgtaaac  atgacaaag  tcaagggaa  cacatcagg  attatgtag  420
cagtaatat  cattgtcct  tatataatc  atgtataat  gttaaggaa  ctttaatcc  480
tattaagca  acatttttg  atacactgc  ttctcttta  ctttctgtg  ctttatcat  540
tgtttgactt  550



<210> 4891
<211> 1812
<212> DNA
<213> Homo sapiens
<308> L11667
<400> 4891

cgtcgctgc  ggtctcccg  agaganctc  ggagtttgg  cggcccggg  ggccactag  60
tactctgat  ttccgtact  aacacgtct  caagtcaag  tgtcgcacc  gtcccccca  120
gccaagccc  ccaacccca  taaccctcg  gtcttcttt  acgtggaca  cggagggga  180
cgagttggt  gaattgtct  agaattgtt  gcagatatc  tacccaaaa  tgcggaaaa  240
tttcgtgca  tgtgtacag  agaaaaagg  attggacac  cgactggga  acctctcca  300
ttcaaagga  gcccttttc  tcgaattat  aagaaattt  tgattcagg  tggagactt  360
tcaaatcag  atgggacag  tggagaaag  atttatggt  aaaaatttg  agatgaaaa  420
ttccattac  agcatgatc  ggagggttt  ctgagcatg  caaatgcag  ccgcaacac  480
aacggttct  agtttttta  cacaacagt  ccaactcct  atttggatg  gaaacatgt  540
gtgtttggc  aagtaatta  aggaatagg  gtggcaagg  tattggaaa  tgtggaagt  600
aaaggtgaa  aacctgcta  attgtgcgt  attgcagaa  gtggagaat  gaaggaagg  660
gatgacggg  gaatattcc  aaaagatgg  tctggcgac  gtcatccag  tttccctga  720
gatgcggat  tagatttaa  agatgtaga  aaaatttta  taataacag  agacttaaa  780
aacattgga  atacttttt  caaatccca  aactgggag  tggctatta  aaaatatgc  840
gaagtttta  gatacgtgg  cagttcaaa  gctgttatt  agacagcag  tagagccaa  900
ctgcaacct  tagctttaa  ctgtgtact  aatattggt  cttgtaaac  gaagatgtc  960
aattggcag  gagcaattg  cagttgttt  gaggctctt  aactagacc  atcaaatac  1020
aaagcattg  accgcagag  tcaaggatg  caaggatta  aagaatatg  tcaagcatt  1080
gctgatctt  agaaagctc  ggggatagc  ccagaagat  aagctatcc  ggcagaatt  1140
ctgaaagtc  aacaaaaga  aaaggcaca  aaagataaa  agaaggcag  atatgcaaa  1200
atgtttgct  agaaaggat  cagttttgc  tattgtgtg  tgattgtat  aatgcaata  1260
gaaaatgta  aggtttttg  ctatgaata  gatccctaa  gtgtttctt  tgacacctt  1320
gttccttac  gtttacagt  taggagtac  gataggggt  catgcttaa  aaacatgtc  1380
caatacagt  agtaaagtg  ttttgtttg  ttctttgag  tggagtctt  ctctgtcac  1440
caggctgga  tgcggtggc  caatctcgg  tcactgcat  ctctgcctc  cgggttcaa  1500
caattctcc  gcctcagct  cccaagtag  tgggattac  ggcacgtgc  accacgccc  1560
gactaattt  tgtattttt  gtagagatg  ggtttcacc  tattggtca  gtcacgttg  1620
tcttgaact  ctgaccttg  gatccaccc  gccttggcc  cccaaagtg  tgggattac  1680
ggtgtgagc  accgtgccc  gccaagtaa  atgtttttt  aaatggtta  gtgcattat  1740
cataaaaaa  aatggtgtc  agtcttttt  aacttgtaa  gacacatct  attgaataa  1800
gagatgaga  cg  1812



<210> 4892
<211> 370
<212> PRT
<213> Homo sapiens
<308> Q08752
<400> 4892

Met Ser His Pro Ser Pro Gln Ala Lys Pro Ser Asn Pro Ser Asn Pro 
  1               5                  10                  15
Arg Val Phe Phe Asp Val Asp Ile Gly Gly Glu Arg Val Gly Arg Ile 
             20                  25                  30
Val Leu Glu Leu Phe Ala Asp Ile Val Pro Lys Thr Ala Glu Asn Phe 
         35                  40                  45
Arg Ala Leu Cys Thr Gly Glu Lys Gly Ile Gly His Thr Thr Gly Lys 
     50                  55                  60
Pro Leu His Phe Lys Gly Cys Pro Phe His Arg Ile Ile Lys Lys Phe 
 65                  70                  75                  80
Met Ile Gln Gly Gly Asp Phe Ser Asn Gln Asn Gly Thr Gly Gly Glu 
                 85                  90                  95
Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe His Tyr Lys His 
             100                105                110
Asp Arg Glu Gly Leu Leu Ser Met Ala Asn Ala Gly Arg Asn Thr Asn 
         115                120                125
Gly Ser Gln Phe Phe Ile Thr Thr Val Pro Thr Pro His Leu Asp Gly 
     130                135                140
Lys His Val Val Phe Gly Gln Val Ile Lys Gly Ile Gly Val Ala Arg 
 145                150                155                160
Ile Leu Glu Asn Val Glu Val Lys Gly Glu Lys Pro Ala Lys Leu Cys 
                 165                170                175
Val Ile Ala Glu Cys Gly Glu Leu Lys Glu Gly Asp Asp Gly Gly Ile 
             180                185                190
Phe Pro Lys Asp Gly Ser Gly Asp Ser His Pro Asp Phe Pro Glu Asp 
         195                200                205
Ala Asp Ile Asp Leu Lys Asp Val Asp Lys Ile Leu Leu Ile Thr Glu 
     210                215                220
Asp Leu Lys Asn Ile Gly Asn Thr Phe Phe Lys Ser Gln Asn Trp Glu 
 225                230                235                240
Met Ala Ile Lys Lys Tyr Ala Glu Val Leu Arg Tyr Val Asp Ser Ser 
                 245                250                255
Lys Ala Val Ile Glu Thr Ala Asp Arg Ala Lys Leu Gln Pro Ile Ala 
             260                265                270
Leu Ser Cys Val Leu Asn Ile Gly Ala Cys Lys Leu Lys Met Ser Asn 
         275                280                285
Trp Gln Gly Ala Ile Asp Ser Cys Leu Glu Ala Leu Glu Leu Asp Pro 
     290                295                300
Ser Asn Thr Lys Ala Leu Tyr Arg Arg Ala Gln Gly Trp Gln Gly Leu 
 305                310                315                320
Lys Glu Tyr Asp Gln Ala Leu Ala Asp Leu Lys Lys Ala Gln Gly Ile 
                 325                330                335
Ala Pro Glu Asp Lys Ala Ile Gln Ala Glu Leu Leu Lys Val Lys Gln 
             340                345                350
Lys Ile Lys Ala Gln Lys Asp Lys Glu Lys Ala Val Tyr Ala Lys Met 
         355                360                365
Phe Ala 
     370



<210> 4893
<211> 619
<212> DNA
<213> Rattus norvegicus
<308> AA850940
<400> 4893

ttttttttt  ttttttttt  ttttcactg  atctttgat  tattcaaat  ggctgtatc  60
ttttgctct  tggaattta  caaatttta  tagtttatg  agcagactt  ttttcttct  120
tggtaggtt  cttctctgc  ggtttcttg  taaccacct  tttccctgc  ggcttcttc  180
gcttcttgg  atccacagg  ttctttcct  ttttgccta  tgcaggttt  ttgtctcca  240
cccccttct  tggaacaat  ttctccgat  tggctgcca  tgcagcagc  gcggcttcc  300
gctttttca  tcgaagttt  tgattccta  cctggcgga  aatggtgtt  ctacgcata  360
tctttgcgt  agggttcag  ttcaacatg  tcctcagat  cttcagtgg  ttcttcttc  420
agactctgc  ctgaatctt  ttgcgtggt  ctcgaaggg  tctttggat  tctgggctt  480
tcaagattc  gctaaggtc  gtgttcatc  tcttgtgca  ggggaggtt  tagttactc  540
tgagggaag  agccttacg  caagtgcca  acaactcat  caacttccg  aaagcactt  600
cagtccaaa  gcagaaacg  619



<210> 4894
<211> 421
<212> PRT
<213> Rattus norvegicus
<308> P50878
<400> 4894

Met Ala Cys Ala Arg Pro Leu Ile Ser Val Tyr Ser Glu Lys Gly Glu 
  1               5                  10                  15
Ser Ser Gly Lys Asn Val Thr Leu Pro Ala Val Phe Lys Ala Pro Ile 
             20                  25                  30
Arg Pro Asp Ile Val Asn Phe Val His Thr Asn Leu Arg Lys Asn Asn 
         35                  40                  45
Arg Gln Pro Tyr Ala Val Ser Glu Leu Ala Gly His Gln Thr Ser Ala 
     50                  55                  60
Glu Ser Trp Gly Thr Gly Arg Ala Val Ala Arg Ile Pro Arg Val Arg 
 65                  70                  75                  80
Gly Gly Gly Thr His Arg Ser Gly Gln Gly Ala Phe Gly Asn Met Cys 
                 85                  90                  95
Arg Gly Gly Arg Met Phe Ala Pro Thr Lys Thr Trp Arg Arg Trp His 
             100                105                110
Arg Arg Val Asn Thr Thr Gln Lys Arg Tyr Ala Ile Cys Ser Ala Leu 
         115                120                125
Ala Ala Ser Ala Leu Pro Ala Leu Val Met Ser Lys Gly His Cys Val 
     130                135                140
Glu Glu Val Pro Glu Leu Pro Leu Val Val Glu Asp Lys Val Glu Ser 
 145                150                155                160
Tyr Lys Lys Thr Lys Glu Ala Val Gln Leu Leu Lys Lys Leu Lys Ala 
                 165                170                175
Trp Asn Asp Ile Lys Lys Val Tyr Ala Ser Gln Arg Met Arg Ala Gly 
             180                185                190
Lys Gly Lys Met Arg Asn Arg Arg Arg Ile Gln Arg Arg Gly Pro Cys 
         195                200                205
Ile Ile Tyr Asn Glu Asp Asn Gly Ile Ile Lys Ala Phe Arg Asn Ile 
     210                215                220
Pro Gly Ile Thr Leu Leu Asn Val Ser Lys Leu Asn Ile Leu Lys Leu 
 225                230                235                240
Ala Pro Gly Gly His Val Gly Arg Phe Cys Ile Trp Thr Glu Ser Ala 
                 245                250                255
Phe Arg Lys Leu Asp Glu Leu Tyr Gly Thr Trp Arg Lys Ala Ala Ser 
             260                265                270
Leu Lys Ser Asn Tyr Asn Leu Pro Met His Lys Met Met Asn Thr Asp 
         275                280                285
Leu Ser Arg Ile Leu Lys Ser Pro Glu Ile Gln Arg Ala Leu Arg Ala 
     290                295                300
Pro Arg Lys Lys Ile His Arg Arg Val Leu Lys Lys Asn Pro Leu Lys 
 305                310                315                320
Asn Leu Arg Ile Met Leu Lys Leu Asn Pro Tyr Ala Lys Thr Met Arg 
                 325                330                335
Arg Asn Thr Ile Leu Arg Gln Ala Arg Asn His Lys Leu Arg Val Lys 
             340                345                350
Lys Leu Glu Ala Ala Ala Ala Ala Leu Ala Ala Lys Ser Glu Lys Ile 
         355                360                365
Val Pro Glu Lys Gly Ala Gly Asp Lys Lys Pro Ala Val Gly Lys Lys 
     370                375                380
Gly Lys Lys Pro Val Asp Ala Lys Lys Leu Lys Lys Pro Ala Gly Lys 
 385                390                395                400
Lys Val Val Thr Lys Lys Pro Ala Glu Lys Lys Pro Thr Thr Glu Glu 
                 405                410                415
Lys Lys Ser Ala Ala 
             420



<210> 4895
<211> 1379
<212> DNA
<213> Homo sapiens
<308> L20868
<400> 4895

tctcctctc  ccgccatgg  tgttgctcg  ccactgata  ccgtgtact  cgaaaaggg  60
gagtcatct  gcaaaaatg  cactttgcc  gctgtcaag  ctcctattc  accagatat  120
gtgaacttt  ttcacacca  ccttcgcga  aaacaagaa  agccctatg  tgtcagtga  180
ttagcaggt  atcagacta  agctgagtc  tggggtact  gcagagctg  ggctcgaat  240
cccagagtt  gaggtggtg  gactcaccg  tctggccag  gtgcttttg  aaacatgtg  300
cgtggaggc  gaatgtttg  accaaccaa  acctggcgc  gttggcatc  tagagtgaa  360
acaacccaa  aacgatacg  catctgttc  gccctggct  cctcagccc  accagcact  420
gtcatgtct  aaggtcatc  tattgagga  ttccctgaa  ttcctttgg  agttgaaga  480
aaagttgaa  gctacaaga  gaccaagga  gctgttttg  tccttaaga  acttaaagc  540
tggaatgat  tcaaaaagg  ctatgcctc  cagcgaatg  gagctggca  aggcaaaat  600
agaaaccgt  gtatccagc  caggggccc  tgcatcatc  ataatgagg  taatggtat  660
atcaaggcc  tcagaaaca  ccctggaat  actctgctt  atgtaagca  gctgaacat  720
ttgaagctt  ctcctggtg  gcatgtggg  cgtttctgc  tttggactg  aagtgcttt  780
cggaagtta  atgaattgt  cggcacttg  cgtaaagcc  cttccctca  gagtaacta  840
aatcttccc  tgcacaaga  gattaatac  gatcttagc  gaatcttga  aagcccaga  900
atccaaaga  cccttcgag  accacgcaa  aagatccat  gcagagtcc  aaagaagaa  960
ccactgaaa  acttgagaa  catgttgaa  ctaaaccca  atgcaaaga  catgcgccg  1020
acaccattc  tcgccaggc  aggaatcac  agctccggg  ggataaggc  gctgctgca  1080
cagcgggca  tacaagcca  atcagatga  aaggcggcg  ttgcaggca  gaagcctgt  1140
gtaggtaag  aaggaaaga  ggctgctgt  ggtgttaag  agcagaaga  gcctctggt  1200
ggaaaaaag  cagcagcta  caagaaacc  gcccctgaa  gaagcctgc  gagaagaaa  1260
ctaactaca  aggagaaga  gcctgctgc  taaactctt  aatttgatt  ttccataaa  1320
gtcaaatca  tttggacag  ttcttttga  taaagacct  ttatacagg  agtgagaaa  1379



<210> 4896
<211> 427
<212> PRT
<213> Homo sapiens
<308> P36578
<400> 4896

Met Ala Cys Ala Arg Pro Leu Ile Ser Val Tyr Ser Glu Lys Gly Glu 
  1               5                  10                  15
Ser Ser Gly Lys Asn Val Thr Leu Pro Ala Val Phe Lys Ala Pro Ile 
             20                  25                  30
Arg Pro Asp Ile Val Asn Phe Val His Thr Asn Leu Arg Lys Asn Asn 
         35                  40                  45
Arg Gln Pro Tyr Ala Val Ser Glu Leu Ala Gly His Gln Thr Ser Ala 
     50                  55                  60
Glu Ser Trp Gly Thr Gly Arg Ala Val Ala Arg Ile Pro Arg Val Arg 
 65                  70                  75                  80
Gly Gly Gly Thr His Arg Ser Gly Gln Gly Ala Phe Gly Asn Met Cys 
                 85                  90                  95
Arg Gly Gly Arg Met Phe Ala Pro Thr Lys Thr Trp Arg Arg Trp His 
             100                105                110
Arg Arg Val Asn Thr Thr Gln Lys Arg Tyr Ala Ile Cys Ser Ala Leu 
         115                120                125
Ala Ala Ser Ala Leu Pro Ala Leu Val Met Ser Lys Gly His Arg Ile 
     130                135                140
Glu Glu Val Pro Glu Leu Pro Leu Val Val Glu Asp Lys Val Glu Gly 
 145                150                155                160
Tyr Lys Lys Thr Lys Glu Ala Val Leu Leu Leu Lys Lys Leu Lys Ala 
                 165                170                175
Trp Asn Asp Ile Lys Lys Val Tyr Ala Ser Gln Arg Met Arg Ala Gly 
             180                185                190
Lys Gly Lys Met Arg Asn Arg Arg Arg Ile Gln Arg Arg Gly Pro Cys 
         195                200                205
Ile Ile Tyr Asn Glu Asp Asn Gly Ile Ile Lys Ala Phe Arg Asn Ile 
     210                215                220
Pro Gly Ile Thr Leu Leu Asn Val Ser Lys Leu Asn Ile Leu Lys Leu 
 225                230                235                240
Ala Pro Gly Gly His Val Gly Arg Phe Cys Ile Trp Thr Glu Ser Ala 
                 245                250                255
Phe Arg Lys Leu Asp Glu Leu Tyr Gly Thr Trp Arg Lys Ala Ala Ser 
             260                265                270
Leu Lys Ser Asn Tyr Asn Leu Pro Met His Lys Met Ile Asn Thr Asp 
         275                280                285
Leu Ser Arg Ile Leu Lys Ser Pro Glu Ile Gln Arg Ala Leu Arg Ala 
     290                295                300
Pro Arg Lys Lys Ile His Arg Arg Val Leu Lys Lys Asn Pro Leu Lys 
 305                310                315                320
Asn Leu Arg Ile Met Leu Lys Leu Asn Pro Tyr Ala Lys Thr Met Arg 
                 325                330                335
Arg Asn Thr Ile Leu Arg Gln Ala Arg Asn His Lys Leu Arg Val Asp 
             340                345                350
Lys Ala Ala Ala Ala Ala Ala Ala Leu Gln Ala Lys Ser Asp Glu Lys 
         355                360                365
Ala Ala Val Ala Gly Lys Lys Pro Val Val Gly Lys Lys Gly Lys Lys 
     370                375                380
Ala Ala Val Gly Val Lys Lys Gln Lys Lys Pro Leu Val Gly Lys Lys 
 385                390                395                400
Ala Ala Ala Thr Lys Lys Pro Ala Pro Glu Lys Lys Pro Ala Glu Lys 
                 405                410                415
Lys Pro Thr Thr Glu Glu Lys Lys Pro Ala Ala 
             420                425



<210> 4897
<211> 618
<212> DNA
<213> Rattus norvegicus
<308> AA851381
<400> 4897

cgcgcggtc  cgtgggtgt  ttgttgggg  agggcccgc  cgttcggtt  cgggcggtt  60
agcgagcta  agaacgagc  agcaagagg  agccgcgcc  gccgccgcg  tctgtatgc  120
gcgttcccc  ggcgcaccc  ccgccgata  tctgagccg  aggagtcgc  gccgctgcg  180
ttgatgtgg  tgggccggg  ctgaccagg  taccaagat  cctcagtcc  agtcccgga  240
gatcgccat  ctgggctat  ggtctgtgg  aaagtcctc  ttgacaatt  agtttgttg  300
aggtcaatt  gttgattcc  acgatccaa  catagaaaa  acattcacc  agctgatca  360
agtaaatgg  caagagtat  atcttcagc  tgtagacac  gcagggcag  atgaatatt  420
catttttcc  cagacatac  ccatagata  taatggtta  attcttgtg  attctgtta  480
atcaatcaa  agctttgaa  taattaaag  tatccacgg  aagctgttg  acatggtgg  540
gaaagtgca  ataccgatt  tgttagtcg  aaataaaaa  gacctgcat  tggaaaggg  600
gatcagtta  gaagaagg  618



<210> 4898
<211> 184
<212> PRT
<213> Rattus norvegicus
<308> Q62639
<400> 4898

Met Pro Gln Ser Lys Ser Arg Lys Ile Ala Ile Leu Gly Tyr Arg Ser 
  1               5                  10                  15
Val Gly Lys Ser Ser Leu Thr Ile Gln Phe Val Glu Gly Gln Phe Val 
             20                  25                  30
Asp Ser Tyr Asp Pro Thr Ile Glu Asn Thr Phe Thr Lys Leu Ile Thr 
         35                  40                  45
Val Asn Gly Gln Glu Tyr His Leu Gln Leu Val Asp Thr Ala Gly Gln 
     50                  55                  60
Asp Glu Tyr Ser Ile Phe Pro Gln Thr Tyr Ser Ile Asp Ile Asn Gly 
 65                  70                  75                  80
Tyr Ile Leu Val Tyr Ser Val Thr Ser Ile Lys Ser Phe Glu Val Ile 
                 85                  90                  95
Lys Val Ile His Gly Lys Leu Leu Asp Met Val Gly Lys Val Gln Ile 
             100                105                110
Pro Ile Met Leu Val Gly Asn Lys Lys Asp Leu His Met Glu Arg Val 
         115                120                125
Ile Ser Tyr Glu Glu Gly Lys Ala Leu Ala Glu Ser Trp Asn Ala Ala 
     130                135                140
Phe Leu Glu Ser Ser Ala Lys Glu Asn Gln Thr Ala Val Asp Val Phe 
 145                150                155                160
Arg Arg Ile Ile Leu Glu Ala Glu Lys Ile Asp Gly Ala Ala Ser Gln 
                 165                170                175
Gly Lys Ser Ser Cys Ser Val Met 
             180



<210> 4899
<211> 241
<212> DNA
<213> Homo sapiens
<308> AW020414
<400> 4899

gcacgagtt  atatattgt  tttcttaat  ttatgacca  gaattttat  ggcattaat  60
tttcagtgt  gtttgttgt  taaaataat  taatcatca  aatgatgca  attgttaca  120
tactattaa  taggcttca  tatatcagt  tttatttca  tgtgttaaa  gtatacttg  180
aaataaaat  gctgcaaac  tcaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  240
a  241



<210> 4900
<211> 184
<212> PRT
<213> Homo sapiens
<308> Q15382
<400> 4900

Met Pro Gln Ser Lys Ser Arg Lys Ile Ala Ile Leu Gly Tyr Arg Ser 
  1               5                  10                  15
Val Gly Lys Ser Ser Leu Thr Ile Gln Phe Val Glu Gly Gln Phe Val 
             20                  25                  30
Asp Ser Tyr Asp Pro Thr Ile Glu Asn Thr Phe Thr Lys Leu Ile Thr 
         35                  40                  45
Val Asn Gly Gln Glu Tyr His Leu Gln Leu Val Asp Thr Ala Gly Gln 
     50                  55                  60
Asp Glu Tyr Ser Ile Phe Pro Gln Thr Tyr Ser Ile Asp Ile Asn Gly 
 65                  70                  75                  80
Tyr Ile Leu Val Tyr Ser Val Thr Ser Ile Lys Ser Phe Glu Val Ile 
                 85                  90                  95
Lys Val Ile His Gly Lys Leu Leu Asp Met Val Gly Lys Val Gln Ile 
             100                105                110
Pro Ile Met Leu Val Gly Asn Lys Lys Asp Leu His Met Glu Arg Val 
         115                120                125
Ile Ser Tyr Glu Glu Gly Lys Ala Leu Ala Glu Ser Trp Asn Ala Ala 
     130                135                140
Phe Leu Glu Ser Ser Ala Lys Glu Asn Gln Thr Ala Val Asp Val Phe 
 145                150                155                160
Arg Arg Ile Ile Leu Glu Ala Glu Lys Met Asp Gly Ala Ala Ser Gln 
                 165                170                175
Gly Lys Ser Ser Cys Ser Val Met 
             180



<210> 4901
<211> 393
<212> DNA
<213> Rattus norvegicus
<308> AA851403
<400> 4901

aaggtgaaa  ctctaggaa  aaggagtcc  attcagagg  cacgagagc  cacggagcc  60
cctcagatc  catagtgaa  cacgggctc  ggttctttg  aaggatcac  gcctcgctc  120
aggtacaga  tattgtacg  gtactgctt  ggaccctaa  gaaggacac  agagaagag  180
aggtgcacg  gtcagcaag  acaatagcc  gccagtcag  caatacctg  ctacaccct  240
cttgagttc  caatcacgc  gagcaaaag  gggtacagt  gcctctggt  agactccga  300
gagctaaac  ggcagaagg  tgctcttgc  ctgctcaac  cacagcaga  agcgcctca  360
ttatgagag  agtagtgtc  gccggcaag  gag  393



<210> 4902
<211> 186
<212> PRT
<213> Rattus norvegicus
<308> NP_080337
<400> 4902

Met Ala Ala Ala Arg Ala Ala Ala Leu Gly Val Arg Trp Leu Gln Arg 
  1               5                  10                  15
Thr Thr Arg Gly Val Val Pro Leu Glu Ala Arg Arg Ala Phe His Met 
             20                  25                  30
Thr Lys Asp Met Leu Pro Gly Ser Tyr Pro Arg Thr Pro Glu Glu Arg 
         35                  40                  45
Ala Ala Ala Ala Lys Lys Tyr Asn Met Arg Val Glu Asp Tyr Glu Pro 
     50                  55                  60
Tyr Pro Asp Asp Gly Met Gly Tyr Gly Asp Tyr Pro Met Leu Pro Asn 
 65                  70                  75                  80
Arg Ser Gln His Glu Arg Asp Pro Trp Tyr Gln Trp Asp His Ser Glu 
                 85                  90                  95
Leu Arg Met Asn Trp Gly Glu Pro Ile His Trp Asp Leu Asp Met Tyr 
             100                105                110
Ile Arg Asn Arg Val Asp Thr Ser Pro Thr Pro Val Ser Trp Asp Val 
         115                120                125
Met Cys Lys His Leu Phe Gly Phe Val Ala Phe Met Val Phe Met Phe 
     130                135                140
Trp Val Gly His Val Phe Pro Ser Tyr Gln Pro Val Gly Pro Lys Gln 
 145                150                155                160
Tyr Pro Tyr Asn Asn Leu Tyr Leu Glu Arg Gly Gly Asp Pro Thr Lys 
                 165                170                175
Glu Pro Glu Pro Val Val His Tyr Asp Ile 
             180                185



<210> 4903
<211> 904
<212> DNA
<213> Homo sapiens
<308> BI488555
<400> 4903

tgaagatgg  ggtggccag  ccggggtct  gggagtcca  tggctgcaa  gggcatccc  60
gaacgtgat  ccgctgggc  cacggacag  ctcccacat  accaaggac  tgttcccgg  120
gccctatcc  aggacccca  aagaacggg  cgccgccgc  aagaagtat  atatgcgtg  180
ggaagacta  gaaccatac  ttccagggg  cccaggtgc  ccatgctct  gtgtcctcc  240
aaccactgg  atcttgact  ctcacccag  acctcaaga  tcctggaaa  aagccccag  300
ccccagggg  aacctccag  ggaacaagc  gccagagac  tttatgccc  cagcaccaa  360
tactgctcc  gttatgagc  tcacccctg  gctacaagg  attcttccc  cacagcccc  420
tgtctccag  gtgagtcat  ctcccccag  agttccagg  gaactcagc  tgcagcagc  480
tcagcacct  ccacctgag  agatggaaa  gaaggagct  cccccagag  atcagtcct  540
gaagagcag  tttgaggcg  ttctccaac  ctgctccct  tctgcaact  acttaaaga  600
aaaaaggaa  ctggaagag  cagcccagc  tctggagta  ctatatgag  agctctgtg  660
ggggacact  tcacctcat  tcgtggctg  gctgcatga  gttgcccga  gtgtggatg  720
aggaagctt  gagcagggc  ttgccagtg  catgcccag  tggcgggct  tagcagctt  780
agccaaggt  tccagcttc  tgcctatcc  gaaggtctg  cctcatcat  gtcataagc  840
gctggtcta  accaggcag  ctctcttgc  tagaggggc  acttctgtg  ttcttaatt  900
tccg  904



<210> 4904
<211> 393
<212> DNA
<213> Rattus norvegicus
<308> AA851403
<400> 4904

aaggtgaaa  ctctaggaa  aaggagtcc  attcagagg  cacgagagc  cacggagcc  60
cctcagatc  catagtgaa  cacgggctc  ggttctttg  aaggatcac  gcctcgctc  120
aggtacaga  tattgtacg  gtactgctt  ggaccctaa  gaaggacac  agagaagag  180
aggtgcacg  gtcagcaag  acaatagcc  gccagtcag  caatacctg  ctacaccct  240
cttgagttc  caatcacgc  gagcaaaag  gggtacagt  gcctctggt  agactccga  300
gagctaaac  ggcagaagg  tgctcttgc  ctgctcaac  cacagcaga  agcgcctca  360
ttatgagag  agtagtgtc  gccggcaag  gag  393



<210> 4905
<211> 186
<212> PRT
<213> Rattus norvegicus
<308> NP_080337
<400> 4905

Met Ala Ala Ala Arg Ala Ala Ala Leu Gly Val Arg Trp Leu Gln Arg 
  1               5                  10                  15
Thr Thr Arg Gly Val Val Pro Leu Glu Ala Arg Arg Ala Phe His Met 
             20                  25                  30
Thr Lys Asp Met Leu Pro Gly Ser Tyr Pro Arg Thr Pro Glu Glu Arg 
         35                  40                  45
Ala Ala Ala Ala Lys Lys Tyr Asn Met Arg Val Glu Asp Tyr Glu Pro 
     50                  55                  60
Tyr Pro Asp Asp Gly Met Gly Tyr Gly Asp Tyr Pro Met Leu Pro Asn 
 65                  70                  75                  80
Arg Ser Gln His Glu Arg Asp Pro Trp Tyr Gln Trp Asp His Ser Glu 
                 85                  90                  95
Leu Arg Met Asn Trp Gly Glu Pro Ile His Trp Asp Leu Asp Met Tyr 
             100                105                110
Ile Arg Asn Arg Val Asp Thr Ser Pro Thr Pro Val Ser Trp Asp Val 
         115                120                125
Met Cys Lys His Leu Phe Gly Phe Val Ala Phe Met Val Phe Met Phe 
     130                135                140
Trp Val Gly His Val Phe Pro Ser Tyr Gln Pro Val Gly Pro Lys Gln 
 145                150                155                160
Tyr Pro Tyr Asn Asn Leu Tyr Leu Glu Arg Gly Gly Asp Pro Thr Lys 
                 165                170                175
Glu Pro Glu Pro Val Val His Tyr Asp Ile 
             180                185



<210> 4906
<211> 904
<212> DNA
<213> Homo sapiens
<308> BI488555
<400> 4906

tgaagatgg  ggtggccag  ccggggtct  gggagtcca  tggctgcaa  gggcatccc  60
gaacgtgat  ccgctgggc  cacggacag  ctcccacat  accaaggac  tgttcccgg  120
gccctatcc  aggacccca  aagaacggg  cgccgccgc  aagaagtat  atatgcgtg  180
ggaagacta  gaaccatac  ttccagggg  cccaggtgc  ccatgctct  gtgtcctcc  240
aaccactgg  atcttgact  ctcacccag  acctcaaga  tcctggaaa  aagccccag  300
ccccagggg  aacctccag  ggaacaagc  gccagagac  tttatgccc  cagcaccaa  360
tactgctcc  gttatgagc  tcacccctg  gctacaagg  attcttccc  cacagcccc  420
tgtctccag  gtgagtcat  ctcccccag  agttccagg  gaactcagc  tgcagcagc  480
tcagcacct  ccacctgag  agatggaaa  gaaggagct  cccccagag  atcagtcct  540
gaagagcag  tttgaggcg  ttctccaac  ctgctccct  tctgcaact  acttaaaga  600
aaaaaggaa  ctggaagag  cagcccagc  tctggagta  ctatatgag  agctctgtg  660
ggggacact  tcacctcat  tcgtggctg  gctgcatga  gttgcccga  gtgtggatg  720
aggaagctt  gagcagggc  ttgccagtg  catgcccag  tggcgggct  tagcagctt  780
agccaaggt  tccagcttc  tgcctatcc  gaaggtctg  cctcatcat  gtcataagc  840
gctggtcta  accaggcag  ctctcttgc  tagaggggc  acttctgtg  ttcttaatt  900
tccg  904



<210> 4907
<211> 393
<212> DNA
<213> Rattus norvegicus
<308> AA851403
<400> 4907

aaggtgaaa  ctctaggaa  aaggagtcc  attcagagg  cacgagagc  cacggagcc  60
cctcagatc  catagtgaa  cacgggctc  ggttctttg  aaggatcac  gcctcgctc  120
aggtacaga  tattgtacg  gtactgctt  ggaccctaa  gaaggacac  agagaagag  180
aggtgcacg  gtcagcaag  acaatagcc  gccagtcag  caatacctg  ctacaccct  240
cttgagttc  caatcacgc  gagcaaaag  gggtacagt  gcctctggt  agactccga  300
gagctaaac  ggcagaagg  tgctcttgc  ctgctcaac  cacagcaga  agcgcctca  360
ttatgagag  agtagtgtc  gccggcaag  gag  393



<210> 4908
<211> 186
<212> PRT
<213> Rattus norvegicus
<308> NP_080337
<400> 4908

Met Ala Ala Ala Arg Ala Ala Ala Leu Gly Val Arg Trp Leu Gln Arg 
  1               5                  10                  15
Thr Thr Arg Gly Val Val Pro Leu Glu Ala Arg Arg Ala Phe His Met 
             20                  25                  30
Thr Lys Asp Met Leu Pro Gly Ser Tyr Pro Arg Thr Pro Glu Glu Arg 
         35                  40                  45
Ala Ala Ala Ala Lys Lys Tyr Asn Met Arg Val Glu Asp Tyr Glu Pro 
     50                  55                  60
Tyr Pro Asp Asp Gly Met Gly Tyr Gly Asp Tyr Pro Met Leu Pro Asn 
 65                  70                  75                  80
Arg Ser Gln His Glu Arg Asp Pro Trp Tyr Gln Trp Asp His Ser Glu 
                 85                  90                  95
Leu Arg Met Asn Trp Gly Glu Pro Ile His Trp Asp Leu Asp Met Tyr 
             100                105                110
Ile Arg Asn Arg Val Asp Thr Ser Pro Thr Pro Val Ser Trp Asp Val 
         115                120                125
Met Cys Lys His Leu Phe Gly Phe Val Ala Phe Met Val Phe Met Phe 
     130                135                140
Trp Val Gly His Val Phe Pro Ser Tyr Gln Pro Val Gly Pro Lys Gln 
 145                150                155                160
Tyr Pro Tyr Asn Asn Leu Tyr Leu Glu Arg Gly Gly Asp Pro Thr Lys 
                 165                170                175
Glu Pro Glu Pro Val Val His Tyr Asp Ile 
             180                185



<210> 4909
<211> 904
<212> DNA
<213> Homo sapiens
<308> BI488555
<400> 4909

tgaagatgg  ggtggccag  ccggggtct  gggagtcca  tggctgcaa  gggcatccc  60
gaacgtgat  ccgctgggc  cacggacag  ctcccacat  accaaggac  tgttcccgg  120
gccctatcc  aggacccca  aagaacggg  cgccgccgc  aagaagtat  atatgcgtg  180
ggaagacta  gaaccatac  ttccagggg  cccaggtgc  ccatgctct  gtgtcctcc  240
aaccactgg  atcttgact  ctcacccag  acctcaaga  tcctggaaa  aagccccag  300
ccccagggg  aacctccag  ggaacaagc  gccagagac  tttatgccc  cagcaccaa  360
tactgctcc  gttatgagc  tcacccctg  gctacaagg  attcttccc  cacagcccc  420
tgtctccag  gtgagtcat  ctcccccag  agttccagg  gaactcagc  tgcagcagc  480
tcagcacct  ccacctgag  agatggaaa  gaaggagct  cccccagag  atcagtcct  540
gaagagcag  tttgaggcg  ttctccaac  ctgctccct  tctgcaact  acttaaaga  600
aaaaaggaa  ctggaagag  cagcccagc  tctggagta  ctatatgag  agctctgtg  660
ggggacact  tcacctcat  tcgtggctg  gctgcatga  gttgcccga  gtgtggatg  720
aggaagctt  gagcagggc  ttgccagtg  catgcccag  tggcgggct  tagcagctt  780
agccaaggt  tccagcttc  tgcctatcc  gaaggtctg  cctcatcat  gtcataagc  840
gctggtcta  accaggcag  ctctcttgc  tagaggggc  acttctgtg  ttcttaatt  900
tccg  904



<210> 4910
<211> 393
<212> DNA
<213> Rattus norvegicus
<308> AA851403
<400> 4910

aaggtgaaa  ctctaggaa  aaggagtcc  attcagagg  cacgagagc  cacggagcc  60
cctcagatc  catagtgaa  cacgggctc  ggttctttg  aaggatcac  gcctcgctc  120
aggtacaga  tattgtacg  gtactgctt  ggaccctaa  gaaggacac  agagaagag  180
aggtgcacg  gtcagcaag  acaatagcc  gccagtcag  caatacctg  ctacaccct  240
cttgagttc  caatcacgc  gagcaaaag  gggtacagt  gcctctggt  agactccga  300
gagctaaac  ggcagaagg  tgctcttgc  ctgctcaac  cacagcaga  agcgcctca  360
ttatgagag  agtagtgtc  gccggcaag  gag  393



<210> 4911
<211> 186
<212> PRT
<213> Rattus norvegicus
<308> NP_080337
<400> 4911

Met Ala Ala Ala Arg Ala Ala Ala Leu Gly Val Arg Trp Leu Gln Arg 
  1               5                  10                  15
Thr Thr Arg Gly Val Val Pro Leu Glu Ala Arg Arg Ala Phe His Met 
             20                  25                  30
Thr Lys Asp Met Leu Pro Gly Ser Tyr Pro Arg Thr Pro Glu Glu Arg 
         35                  40                  45
Ala Ala Ala Ala Lys Lys Tyr Asn Met Arg Val Glu Asp Tyr Glu Pro 
     50                  55                  60
Tyr Pro Asp Asp Gly Met Gly Tyr Gly Asp Tyr Pro Met Leu Pro Asn 
 65                  70                  75                  80
Arg Ser Gln His Glu Arg Asp Pro Trp Tyr Gln Trp Asp His Ser Glu 
                 85                  90                  95
Leu Arg Met Asn Trp Gly Glu Pro Ile His Trp Asp Leu Asp Met Tyr 
             100                105                110
Ile Arg Asn Arg Val Asp Thr Ser Pro Thr Pro Val Ser Trp Asp Val 
         115                120                125
Met Cys Lys His Leu Phe Gly Phe Val Ala Phe Met Val Phe Met Phe 
     130                135                140
Trp Val Gly His Val Phe Pro Ser Tyr Gln Pro Val Gly Pro Lys Gln 
 145                150                155                160
Tyr Pro Tyr Asn Asn Leu Tyr Leu Glu Arg Gly Gly Asp Pro Thr Lys 
                 165                170                175
Glu Pro Glu Pro Val Val His Tyr Asp Ile 
             180                185



<210> 4912
<211> 904
<212> DNA
<213> Homo sapiens
<308> BI488555
<400> 4912

tgaagatgg  ggtggccag  ccggggtct  gggagtcca  tggctgcaa  gggcatccc  60
gaacgtgat  ccgctgggc  cacggacag  ctcccacat  accaaggac  tgttcccgg  120
gccctatcc  aggacccca  aagaacggg  cgccgccgc  aagaagtat  atatgcgtg  180
ggaagacta  gaaccatac  ttccagggg  cccaggtgc  ccatgctct  gtgtcctcc  240
aaccactgg  atcttgact  ctcacccag  acctcaaga  tcctggaaa  aagccccag  300
ccccagggg  aacctccag  ggaacaagc  gccagagac  tttatgccc  cagcaccaa  360
tactgctcc  gttatgagc  tcacccctg  gctacaagg  attcttccc  cacagcccc  420
tgtctccag  gtgagtcat  ctcccccag  agttccagg  gaactcagc  tgcagcagc  480
tcagcacct  ccacctgag  agatggaaa  gaaggagct  cccccagag  atcagtcct  540
gaagagcag  tttgaggcg  ttctccaac  ctgctccct  tctgcaact  acttaaaga  600
aaaaaggaa  ctggaagag  cagcccagc  tctggagta  ctatatgag  agctctgtg  660
ggggacact  tcacctcat  tcgtggctg  gctgcatga  gttgcccga  gtgtggatg  720
aggaagctt  gagcagggc  ttgccagtg  catgcccag  tggcgggct  tagcagctt  780
agccaaggt  tccagcttc  tgcctatcc  gaaggtctg  cctcatcat  gtcataagc  840
gctggtcta  accaggcag  ctctcttgc  tagaggggc  acttctgtg  ttcttaatt  900
tccg  904



<210> 4913
<211> 368
<212> DNA
<213> Rattus norvegicus
<308> AA852004
<400> 4913

aacatttaa  tataaaaat  ctactctgc  ttgagttat  aatggagga  caagaaact  60
ttttcttcc  ttacagtag  gccatttgt  aggtgaact  tgtttcatg  agggagggt  120
aactcccct  ccctaagct  aggaagcca  gagaccaac  tccaactcc  caccagact  180
caatagaaa  ctggtttca  cggaagaaa  aacagctct  tactgacag  gaaaatgtt  240
atctaagct  ttgggcctg  cctttcaat  atcctgaag  aaaaaaaaa  ccagtcctc  300
ctcaccaca  gtacacccg  tttgtgaca  ctatgccta  aggacatgc  ttcccgctg  360
gatgaagc  368



<210> 4914
<211> 373
<212> PRT
<213> Rattus norvegicus
<308> P09606
<400> 4914

Met Ala Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Met 
  1               5                  10                  15
Tyr Met Asn Leu Pro Gln Gly Glu Lys Ile Gln Leu Met Tyr Ile Trp 
             20                  25                  30
Val Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
         35                  40                  45
Cys Asp Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
     50                  55                  60
Ser Ser Thr Phe Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu His 
 65                  70                  75                  80
Pro Val Ala Met Phe Arg Asp Pro Phe Arg Arg Asp Pro Asn Lys Leu 
                 85                  90                  95
Val Phe Cys Glu Val Phe Lys Tyr Asn Arg Lys Pro Ala Glu Thr Asn 
             100                105                110
Leu Arg His Ser Cys Lys Arg Ile Met Asp Met Val Ser Ser Gln His 
         115                120                125
Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
     130                135                140
His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
 145                150                155                160
Tyr Tyr Cys Gly Val Gly Ala Asp Lys Ala Tyr Gly Arg Asp Ile Val 
                 165                170                175
Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Ile Lys Ile Thr Gly 
             180                185                190
Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
         195                200                205
Cys Glu Gly Ile Arg Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
     210                215                220
Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
 225                230                235                240
Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                 245                250                255
Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Arg Cys Ile Glu Glu 
             260                265                270
Ala Ile Asp Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
         275                280                285
Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
     290                295                300
Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 
 305                310                315                320
Ala Ser Ile Arg Ile Pro Arg Ile Val Gly Gln Glu Lys Lys Gly Tyr 
                 325                330                335
Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Tyr Ala Val Thr 
             340                345                350
Glu Ala Ile Val Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
         355                360                365
Phe Gln Tyr Lys Asn 
     370



<210> 4915
<211> 494
<212> DNA
<213> Rattus norvegicus
<308> AA852055
<400> 4915

gctcatggg  gccccagtg  agatgacag  gtctcaggg  cagccagtg  agcttaact  60
cagtgtgga  gggatggag  accctgaca  acactggat  aaggatggc  ctgtggtcc  120
gaatgcaag  caggtgtcc  tctcaataa  cgaacagaa  tggattggc  tactcagcc  180
aaagtcagc  gagcggtct  atgccggcc  gtactggtg  caggtgaag  atggggagg  240
aaccaagat  tctcagtca  tatggctca  tgttgaagg  gtgccattc  tcacggtgg  300
accaaaaga  ctggcggtg  cacccaatg  cccttttca  ctgtcttgt  aggctgtgg  360
tccaccaga  cccgtaacc  ttttctggt  gagaggacc  actaaggtt  ggggacctg  420
ttcctctcc  tctgtttta  atgtaacag  agtgactca  cgcacagag  tttcttgtg  480
agctcataa  ataa  494



<210> 4916
<211> 880
<212> PRT
<213> Rattus norvegicus
<308> P55146
<400> 4916

Met Ala Leu Arg Arg Ser Met Gly Arg Pro Gly Leu Arg Pro Leu Leu 
  1               5                  10                  15
Leu Ala Gly Leu Ala Ser Leu Leu Leu Pro Gly Ser Ala Ala Ala Gly 
             20                  25                  30
Leu Lys Leu Met Gly Ala Pro Val Lys Met Thr Val Ser Gln Gly Gln 
         35                  40                  45
Pro Val Lys Leu Asn Cys Ser Val Glu Gly Met Asp Asp Pro Asp Ile 
     50                  55                  60
His Trp Met Lys Asp Gly Ala Val Val Gln Asn Ala Ser Gln Val Ser 
 65                  70                  75                  80
Ile Ser Ile Ser Glu Gln Asn Trp Ile Gly Leu Leu Ser Leu Lys Ser 
                 85                  90                  95
Ala Glu Arg Ser Asp Ala Gly Leu Tyr Trp Cys Gln Val Lys Asp Gly 
             100                105                110
Glu Glu Thr Lys Ile Ser Gln Ser Val Trp Leu Thr Val Glu Gly Val 
         115                120                125
Pro Phe Phe Thr Val Glu Pro Lys Asp Leu Ala Val Pro Pro Asn Val 
     130                135                140
Pro Phe Gln Leu Ser Cys Glu Ala Val Gly Pro Pro Glu Pro Val Thr 
 145                150                155                160
Ile Phe Trp Trp Arg Gly Pro Thr Lys Val Gly Gly Pro Ala Ser Ser 
                 165                170                175
Pro Ser Val Leu Asn Val Thr Gly Val Thr Gln Arg Thr Glu Phe Ser 
             180                185                190
Cys Glu Ala His Asn Ile Lys Gly Leu Ala Thr Ser Arg Pro Ala Ile 
         195                200                205
Ile Arg Leu Gln Ala Pro Pro Ala Ala Pro Phe Asn Ile Thr Val Thr 
     210                215                220
Thr Ile Ser Ser Ser Asn Ala Ser Val Ala Trp Val Pro Gly Ala Asp 
 225                230                235                240
Gly Leu Ala Leu Leu His Ser Cys Thr Val Gln Val Ala His Ala Pro 
                 245                250                255
Gly Glu Trp Glu Ala Leu Ala Val Val Val Pro Val Pro Pro Phe Thr 
             260                265                270
Cys Leu Leu Arg Asn Leu Ala Pro Ala Thr Asn Tyr Ser Leu Arg Val 
         275                280                285
Arg Cys Ala Asn Ala Leu Gly Pro Ser Pro Tyr Gly Asp Trp Val Pro 
     290                295                300
Phe Gln Thr Lys Gly Leu Ala Pro Ala Arg Ala Pro Gln Asn Phe His 
 305                310                315                320
Ala Ile Arg Thr Asp Ser Gly Leu Ile Leu Glu Trp Glu Glu Val Ile 
                 325                330                335
Pro Glu Asp Pro Gly Glu Gly Pro Leu Gly Pro Tyr Lys Leu Ser Trp 
             340                345                350
Val Gln Glu Asn Gly Thr Gln Asp Glu Leu Met Val Glu Gly Thr Thr 
         355                360                365
Ala Asn Leu Thr Asp Trp Asp Pro Gln Lys Asp Leu Val Leu Arg Val 
     370                375                380
Cys Ala Ser Asn Ala Ile Gly Asp Gly Pro Trp Ser Gln Pro Leu Val 
 385                390                395                400
Val Ser Ser His Asp His Ala Gly Arg Gln Gly Pro Pro His Ser Arg 
                 405                410                415
Thr Ser Trp Val Pro Val Val Leu Gly Val Leu Thr Ala Leu Ile Thr 
             420                425                430
Ala Ala Ala Leu Ala Leu Ile Leu Leu Arg Lys Arg Arg Lys Glu Thr 
         435                440                445
Arg Phe Gly Gln Ala Phe Asp Ser Val Met Ala Arg Gly Glu Pro Ala 
     450                455                460
Val His Phe Arg Ala Ala Arg Ser Phe Asn Arg Glu Arg Pro Glu Arg 
 465                470                475                480
Ile Glu Ala Thr Leu Asp Ser Leu Gly Ile Ser Asp Glu Leu Lys Glu 
                 485                490                495
Lys Leu Glu Asp Val Leu Ile Pro Glu Gln Gln Phe Thr Leu Gly Arg 
             500                505                510
Met Leu Gly Lys Gly Glu Phe Gly Ser Val Arg Glu Ala Gln Leu Lys 
         515                520                525
Gln Glu Asp Gly Ser Phe Val Lys Val Ala Val Lys Met Leu Lys Ala 
     530                535                540
Asp Ile Ile Ala Ser Ser Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala 
 545                550                555                560
Cys Met Lys Glu Phe Asp His Pro His Val Ala Lys Leu Val Gly Val 
                 565                570                575
Ser Leu Arg Ser Arg Ala Lys Gly Arg Leu Pro Ile Pro Met Val Ile 
             580                585                590
Leu Pro Phe Met Lys His Gly Asp Leu His Ala Phe Leu Leu Ala Ser 
         595                600                605
Arg Ile Gly Glu Asn Pro Phe Asn Leu Pro Leu Gln Thr Leu Val Arg 
     610                615                620
Phe Met Val Asp Ile Ala Cys Gly Met Glu Tyr Leu Ser Ser Arg Asn 
 625                630                635                640
Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Ala Glu Asp 
                 645                650                655
Met Thr Val Cys Val Ala Asp Phe Gly Leu Ser Arg Lys Ile Tyr Ser 
             660                665                670
Gly Asp Tyr Tyr Arg Gln Gly Cys Ala Ser Lys Leu Pro Val Lys Trp 
         675                680                685
Leu Ala Leu Glu Ser Leu Ala Asp Asn Leu Tyr Thr Val His Ser Asp 
     690                695                700
Val Trp Ala Phe Gly Val Thr Met Trp Glu Ile Met Thr Arg Gly Gln 
 705                710                715                720
Thr Pro Tyr Ala Gly Ile Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile 
                 725                730                735
Ser Gly Asn Arg Leu Lys Gln Pro Pro Glu Cys Met Glu Glu Val Tyr 
             740                745                750
Asp Leu Met Tyr Gln Cys Trp Ser Ala Asp Pro Lys Gln Arg Pro Ser 
         755                760                765
Phe Thr Cys Leu Arg Met Glu Leu Glu Asn Ile Leu Gly His Leu Ser 
     770                775                780
Val Leu Ser Thr Ser Gln Asp Pro Leu Tyr Ile Asn Ile Glu Arg Ala 
 785                790                795                800
Gly Gln Pro Ala Glu Asn Gly Ser Pro Glu Leu Pro Cys Gly Glu Gln 
                 805                810                815
Ser Ser Ser Glu Ala Gly Asp Gly Ser Gly Met Gly Ala Ile Gly Gly 
             820                825                830
Ile Pro Ser Asp Cys Arg Tyr Ile Phe Ser Pro Gly Gly Leu Ala Glu 
         835                840                845
Ser Pro Gly Gln Leu Glu Gln Gln Pro Glu Ser Pro Leu Asn Glu Asn 
     850                855                860
Gln Arg Leu Leu Leu Leu Gln Gln Gly Leu Leu Pro His Ser Ser Cys 
 865                870                875                880



<210> 4917
<211> 3031
<212> DNA
<213> Homo sapiens
<308> U02566
<400> 4917

cctctccat  tgttttaaa  gtaacaggg  tgacccaga  caccatgtt  tcctgtgaa  60
ctcacaacc  aaaaggcct  gcctcttct  gcacagcca  tgttcacct  caagcactg  120
ctgcagccc  cttcaacat  accgtgaca  agctttcca  cagcaacgc  agtgtggcc  180
ggatgccag  tgctgatgg  cgagctctg  tacagtcct  tacagttca  gtgacacag  240
ccccaggag  ctgggaagt  ctggctgtt  tggtccctg  gcccccctt  acctgcctg  300
tccgggacc  ggtgcctgc  accaactac  gcctcaggg  gcgctgtgc  aatgccttg  360
ggccctctc  ctatgctga  tgggtgccc  ttcagacca  gggtctagc  ccagccagc  420
ctccccaaa  cctccatgc  atccgcaca  attcaggcc  catcttgga  tgggaagaa  480
tgatccccg  ggccccttt  gaaggcccc  tgggaccct  caaactgtc  tgggttcaa  540
acaatggaa  ccaggatga  ctgacagtg  aggggacca  ggccaattt  acaggctgg  600
atccccaaa  ggacctgat  gtacgtgtg  gcgtctcca  tgcagttgg  tgtggaccc  660
ggagtcagc  actggtggt  tcttctcat  accgtgcag  ccagcaggg  cctcctcac  720
gccgcacat  ctgggtacc  gtggtcctt  gtgtgctaa  ggccctggt  acggctgct  780
ccctggccc  catcctgct  cgaaagaga  ggaaagaga  gcggtttgg  caagccttt  840
acagtgtca  ggcccgggg  gagccagcc  ttcacttcc  ggcagcccg  tccttcaat  900
gagaaaggc  cgagcgcat  gaggccaca  tggacagct  gggcatcag  gatgaacta  960
aggaaaaac  ggaggatgt  ctcatccca  agcagcagt  caccctggg  cggatgttg  1020
gcaaaggag  gtttggttc  gtgcgggag  cccagctga  gcaagagga  ggctccttt  1080
tgaaagtgg  tgtgaagat  ctgaaagct  acatcattg  ctcaagcga  attgaagag  1140
tcctcaggg  agcagcttg  atgaaggag  ttgaccatc  acacgtggc  aaacttgtt  1200
gggtaagcc  ccggagcag  gctaaaggc  gtctcccca  ccccatggt  atcttgccc  1260
tcatgaagc  tggggacct  catgccttc  tgctcgcct  ccggattgg  gagaacccc  1320
ttaacctac  cctccagac  ctgatccgg  tcatggtgg  cacttgcgg  atggagtac  1380
tgagctctc  gaacttcat  caccgagac  tggctgctc  gaattgcat  ctggcagag  1440
acatgacag  gtgtgtggc  gacttcgga  tctcccgga  gatctacag  ggggactac  1500
atcgtcaag  ctgtgcctc  aaactgcct  tcaagtggc  ggccctgga  agcctggcc  1560
acaacctgt  tactgtgca  agtgacgtg  gggcgttcg  ggtgaccat  tgggagatc  1620
tgacacgtg  gcagacgcc  tatgctggc  tcgaaaacg  tgagattta  aactacctc  1680
ttggcggga  cctgaaaca  cctccggag  gtatggagg  cgtgtatga  ctcatgtac  1740
agtgctgga  tgctgaccc  aagcagcgc  cgagcttta  ttgtctgcg  atggaactg  1800
agaacatct  gggccagct  tctgtgcta  ctgccagcc  ggacccctt  tacatcaac  1860
tcgagagag  tgaggagcc  actgcggga  gcagcctgg  gctacctgg  agggatcag  1920
cctacagtg  ggctgggga  ggcagtggc  tgggggcag  gggtggcac  cccagtgac  1980
gtcggtaca  actcacccc  ggagggctg  ctgagcagc  agggcaggc  gagcaccag  2040
cagagagtc  cctcaatga  acacagagg  ttttgctgc  gcagcaagg  ctactgcac  2100
cagtagctg  tagcccaca  gagagggca  cggggccat  tgcggctct  gtggccact  2160
agctggctg  ctaagcccc  tctgacccc  gcccagaca  caaggtgtg  aggctcctg  2220
ggtagtcct  ccaagctgt  ctgggaagc  cggactgac  aaatcaccc  atcccagtt  2280
ttcctgcaa  cactctgtg  cagcctggc  tcagtttag  ccttggctt  attggaagt  2340
ggccagtcc  ggttgtctg  acccaggca  ctggcagga  tggggtggt  atgtttcta  2400
gttacatgg  gtggatggc  gtgtgggag  gcaggtcag  tctgtggcc  acctctcct  2460
ctgagctgc  cctgctgct  aagtgcatg  attgagctg  ctccagcct  gtggcccag  2520
tattaccac  cttggggtt  aaatattcc  ggtgtgccc  tccaagtca  aaagagatg  2580
ccttgtaat  ttccctttt  ggtgagggt  ggtaagggg  tggtatctc  ggtctgaat  2640
ttcaaccat  tttctgatt  cgcaccctg  ctacgccag  agaagttga  gggagcatg  2700
ttccctgca  ctgaccggg  cacacaaag  catgctgga  tacccagcc  atcaggtgc  2760
cctcttcca  aggcagcgt  ccgagccag  aagaggaag  ggtgctgtg  ggcttgccc  2820
ggagcaagt  aggccggag  ggagttcag  aacccttct  catacccac  atctgagca  2880
gctaccaaa  ctcaaaata  cctaagact  acaaaggca  ctgtgtctg  gcccaaccc  2940
tctaaacgg  gacctttag  gccaacttc  cctctaact  gacagcctc  tctgtccca  3000
gtctccaga  agaaatcag  cctgatgag  g  3031



<210> 4918
<211> 890
<212> PRT
<213> Homo sapiens
<308> Q06418
<400> 4918

Met Ala Leu Arg Arg Ser Met Gly Arg Pro Gly Leu Pro Pro Leu Pro 
  1               5                  10                  15
Leu Pro Pro Pro Pro Arg Leu Gly Leu Leu Leu Ala Ala Leu Ala Ser 
             20                  25                  30
Leu Leu Leu Pro Glu Ser Ala Ala Ala Gly Leu Lys Leu Met Gly Ala 
         35                  40                  45
Pro Val Lys Leu Thr Val Ser Gln Gly Gln Pro Val Lys Leu Asn Cys 
     50                  55                  60
Ser Val Glu Gly Met Glu Glu Pro Asp Ile Gln Trp Val Lys Asp Gly 
 65                  70                  75                  80
Ala Val Val Gln Asn Leu Asp Gln Leu Tyr Ile Pro Val Ser Glu Gln 
                 85                  90                  95
His Trp Ile Gly Phe Leu Ser Leu Lys Ser Val Glu Arg Ser Asp Ala 
             100                105                110
Gly Arg Tyr Trp Cys Gln Val Glu Asp Gly Gly Glu Thr Glu Ile Ser 
         115                120                125
Gln Pro Val Trp Leu Thr Val Glu Gly Val Pro Phe Phe Thr Val Glu 
     130                135                140
Pro Lys Asp Leu Ala Val Pro Pro Asn Ala Pro Phe Gln Leu Ser Cys 
 145                150                155                160
Glu Ala Val Gly Pro Pro Glu Pro Val Thr Ile Val Trp Trp Arg Gly 
                 165                170                175
Thr Thr Lys Ile Gly Gly Pro Ala Pro Ser Pro Ser Val Leu Asn Val 
             180                185                190
Thr Gly Val Thr Gln Ser Thr Met Phe Ser Cys Glu Ala His Asn Leu 
         195                200                205
Lys Gly Leu Ala Ser Ser Arg Thr Ala Thr Val His Leu Gln Ala Leu 
     210                215                220
Pro Ala Ala Pro Phe Asn Ile Thr Val Thr Lys Leu Ser Ser Ser Asn 
 225                230                235                240
Ala Ser Val Ala Trp Met Pro Gly Ala Asp Gly Arg Ala Leu Leu Gln 
                 245                250                255
Ser Cys Thr Val Gln Val Thr Gln Ala Pro Gly Gly Trp Glu Val Leu 
             260                265                270
Ala Val Val Val Pro Val Pro Pro Phe Thr Cys Leu Leu Arg Asp Leu 
         275                280                285
Val Pro Ala Thr Asn Tyr Ser Leu Arg Val Arg Cys Ala Asn Ala Leu 
     290                295                300
Gly Pro Ser Pro Tyr Ala Asp Trp Val Pro Phe Gln Thr Lys Gly Leu 
 305                310                315                320
Ala Pro Ala Ser Ala Pro Gln Asn Leu His Ala Ile Arg Thr Asp Ser 
                 325                330                335
Gly Leu Ile Leu Glu Trp Glu Glu Val Ile Pro Glu Ala Pro Leu Glu 
             340                345                350
Gly Pro Leu Gly Pro Tyr Lys Leu Ser Trp Val Gln Asp Asn Gly Thr 
         355                360                365
Gln Asp Glu Leu Thr Val Glu Gly Thr Arg Ala Asn Leu Thr Gly Trp 
     370                375                380
Asp Pro Gln Lys Asp Leu Ile Val Arg Val Cys Val Ser Asn Ala Val 
 385                390                395                400
Gly Cys Gly Pro Trp Ser Gln Pro Leu Val Val Ser Ser His Asp Arg 
                 405                410                415
Ala Gly Gln Gln Gly Pro Pro His Ser Arg Thr Ser Trp Val Pro Val 
             420                425                430
Val Leu Gly Val Leu Thr Ala Leu Val Thr Ala Ala Ala Leu Ala Leu 
         435                440                445
Ile Leu Leu Arg Lys Arg Arg Lys Glu Thr Arg Phe Gly Gln Ala Phe 
     450                455                460
Asp Ser Val Met Ala Arg Gly Glu Pro Ala Val His Phe Arg Ala Ala 
 465                470                475                480
Arg Ser Phe Asn Arg Glu Arg Pro Glu Arg Ile Glu Ala Thr Leu Asp 
                 485                490                495
Ser Leu Gly Ile Ser Asp Glu Leu Lys Glu Lys Leu Glu Asp Val Leu 
             500                505                510
Ile Pro Glu Gln Gln Phe Thr Leu Gly Arg Met Leu Gly Lys Gly Glu 
         515                520                525
Phe Gly Ser Val Arg Glu Ala Gln Leu Lys Gln Glu Asp Gly Ser Phe 
     530                535                540
Val Lys Val Ala Val Lys Met Leu Lys Ala Asp Ile Ile Ala Ser Ser 
 545                550                555                560
Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala Cys Met Lys Glu Phe Asp 
                 565                570                575
His Pro His Val Ala Lys Leu Val Gly Val Ser Leu Arg Ser Arg Ala 
             580                585                590
Lys Gly Arg Leu Pro Ile Pro Met Val Ile Leu Pro Phe Met Lys His 
         595                600                605
Gly Asp Leu His Ala Phe Leu Leu Ala Ser Arg Ile Gly Glu Asn Pro 
     610                615                620
Phe Asn Leu Pro Leu Gln Thr Leu Ile Arg Phe Met Val Asp Ile Ala 
 625                630                635                640
Cys Gly Met Glu Tyr Leu Ser Ser Arg Asn Phe Ile His Arg Asp Leu 
                 645                650                655
Ala Ala Arg Asn Cys Met Leu Ala Glu Asp Met Thr Val Cys Val Ala 
             660                665                670
Asp Phe Gly Leu Ser Arg Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln 
         675                680                685
Gly Cys Ala Ser Lys Leu Pro Val Lys Trp Leu Ala Leu Glu Ser Leu 
     690                695                700
Ala Asp Asn Leu Tyr Thr Val Gln Ser Asp Val Trp Ala Phe Gly Val 
 705                710                715                720
Thr Met Trp Glu Ile Met Thr Arg Gly Gln Thr Pro Tyr Ala Gly Ile 
                 725                730                735
Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile Gly Gly Asn Arg Leu Lys 
             740                745                750
Gln Pro Pro Glu Cys Met Glu Asp Val Tyr Asp Leu Met Tyr Gln Cys 
         755                760                765
Trp Ser Ala Asp Pro Lys Gln Arg Pro Ser Phe Thr Cys Leu Arg Met 
     770                775                780
Glu Leu Glu Asn Ile Leu Gly Gln Leu Ser Val Leu Ser Ala Ser Gln 
 785                790                795                800
Asp Pro Leu Tyr Ile Asn Ile Glu Arg Ala Glu Glu Pro Thr Ala Gly 
                 805                810                815
Gly Ser Leu Glu Leu Pro Gly Arg Asp Gln Pro Tyr Ser Gly Ala Gly 
             820                825                830
Asp Gly Ser Gly Met Gly Ala Val Gly Gly Thr Pro Ser Asp Cys Arg 
         835                840                845
Tyr Ile Leu Thr Pro Gly Gly Leu Ala Glu Gln Pro Gly Gln Ala Glu 
     850                855                860
His Gln Pro Glu Ser Pro Leu Asn Glu Thr Gln Arg Leu Leu Leu Leu 
 865                870                875                880
Gln Gln Gly Leu Leu Pro His Ser Ser Cys 
                 885                890



<210> 4919
<211> 453
<212> DNA
<213> Rattus norvegicus
<308> AA858572
<400> 4919

ttttttttt  tttttttct  tttgggggc  ttccacttt  ttgtttctg  gacagggtt  60
catggagct  tggctggcc  acgatgacc  taaacttct  cttttccaa  atgtacatc  120
tgggttctg  gattacagg  gcgagccac  gtgagtgat  tatgtggtt  gggatggaa  180
ccgggactt  gatgcagtc  ctattaact  aatcccggc  ctggcccta  gtctgtgta  240
actggcaga  acgttcaga  gtccatgtg  agatgggta  acgtgcagg  agaagccag  300
ggttcttcg  gagtcatca  cttgttatt  gagatggga  cctccactg  cctggaact  360
accaggcag  tcaggttcc  taactagga  gccctaggg  ccctcctga  tctccgtcc  420
aagcactgg  attacaagt  cctgaagcc  cac  453



<210> 4920
<211> 430
<212> DNA
<213> Rattus norvegicus
<308> AA858586
<400> 4920

ttttttttt  tttttttca  gcagtttct  tttattgaa  ggcctgaac  caaaggcaa  60
ctgggacag  agaaagaag  caggacatt  ctcatactg  tctgattcc  agagtacca  120
tggaggagg  aaaggaaat  cacattgat  gccctggct  gccccatac  cagggttcc  180
tccgaggcc  atcattgcc  gatctggct  cttgctccg  gtctgcact  cacgcttgg  240
cctcaggcc  cgatcagct  ccctaagaa  cggaggttt  gaatcttga  ctgctggtc  300
tccaggtcc  ttcggctga  gccatcctc  ccatcagta  tcagaacga  ccccgtacc  360
actcggtcc  cacccagaa  cactttcac  ttgttgttc  tggtagcgg  catgggctc  420
agatgctcac  430



<210> 4921
<211> 1082
<212> PRT
<213> Rattus norvegicus
<308> AAC40052
<400> 4921

Met Ser Asp Ser Glu Asp Ser Asn Phe Ser Glu Glu Glu Asp Ser Glu 
  1               5                  10                  15
Arg Ser Ser Glu Ala Glu Glu Ala Glu Val Glu Glu Asp Gln Arg Ser 
             20                  25                  30
Ala Ala Gly Ser Glu Lys Glu Glu Glu Pro Glu Glu Glu Glu Glu Glu 
         35                  40                  45
Glu Glu Glu Tyr Asp Glu Glu Glu Glu Glu Glu Asp Asp Asp Arg Pro 
     50                  55                  60
Pro Lys Lys Pro Arg His Gly Gly Phe Ile Leu Asp Glu Ala Asp Val 
 65                  70                  75                  80
Asp Asp Glu Tyr Glu Asp Glu Asp Gln Trp Glu Asp Gly Ala Glu Asp 
                 85                  90                  95
Ile Leu Glu Lys Glu Glu Ile Glu Ala Ser Asn Ile Asp Asn Val Val 
             100                105                110
Leu Asp Glu Asp Arg Ser Gly Ala Arg Arg Leu Gln Asn Leu Trp Arg 
         115                120                125
Asp Gln Arg Glu Glu Glu Leu Gly Glu Tyr Tyr Met Lys Lys Tyr Ala 
     130                135                140
Lys Ser Ser Val Gly Glu Thr Val Tyr Gly Gly Ser Asp Glu Leu Ser 
 145                150                155                160
Asp Asp Ile Thr Gln Gln Gln Leu Leu Pro Gly Val Lys Asp Pro Asn 
                 165                170                175
Leu Trp Thr Val Lys Cys Lys Ile Gly Glu Glu Arg Ala Thr Ala Ile 
             180                185                190
Ser Leu Met Arg Lys Phe Ile Ala Tyr Gln Phe Thr Asp Thr Pro Leu 
         195                200                205
Gln Ile Lys Ser Val Val Ala Pro Glu His Val Lys Gly Tyr Ile Tyr 
     210                215                220
Val Glu Ala Tyr Lys Gln Thr His Val Lys Gln Ala Ile Glu Gly Val 
 225                230                235                240
Gly Asn Leu Arg Leu Gly Tyr Trp Asn Gln Gln Met Val Pro Ile Lys 
                 245                250                255
Glu Met Thr Asp Val Leu Lys Val Val Lys Glu Val Ala Asn Leu Lys 
             260                265                270
Pro Lys Ser Trp Val Arg Leu Lys Arg Gly Ile Tyr Lys Asp Asp Ile 
         275                280                285
Ala Gln Val Asp Tyr Val Glu Pro Ser Gln Asn Thr Ile Ser Leu Lys 
     290                295                300
Met Ile Pro Arg Ile Asp Tyr Asp Arg Ile Lys Ala Arg Met Ser Leu 
 305                310                315                320
Lys Asp Trp Phe Ala Lys Arg Lys Lys Phe Lys Arg Pro Pro Gln Arg 
                 325                330                335
Leu Phe Asp Ala Glu Lys Ile Arg Ser Leu Gly Gly Asp Val Ala Ser 
             340                345                350
Asp Gly Asp Phe Leu Ile Phe Glu Gly Asn Arg Tyr Ser Arg Lys Gly 
         355                360                365
Phe Leu Phe Lys Ser Phe Ala Met Ser Ala Val Ile Thr Glu Gly Val 
     370                375                380
Lys Pro Thr Leu Ser Glu Leu Glu Lys Phe Glu Asp Gln Pro Glu Gly 
 385                390                395                400
Ile Asp Leu Glu Val Val Thr Glu Ser Thr Gly Lys Glu Arg Glu His 
                 405                410                415
Asn Phe Gln Pro Gly Asp Asn Val Glu Val Cys Glu Gly Glu Leu Ile 
             420                425                430
Asn Leu Gln Gly Lys Val Leu Ser Val Asp Gly Asn Lys Ile Thr Ile 
         435                440                445
Met Pro Lys His Glu Asp Leu Lys Asp Met Leu Glu Phe Pro Ala Gln 
     450                455                460
Glu Leu Arg Lys Tyr Phe Lys Met Gly Asp His Val Lys Val Ile Ala 
 465                470                475                480
Gly Arg Phe Glu Gly Asp Thr Gly Leu Ile Val Arg Val Glu Glu Asn 
                 485                490                495
Phe Val Ile Leu Phe Ser Asp Leu Thr Met His Glu Leu Lys Val Leu 
             500                505                510
Pro Arg Asp Leu Gln Leu Cys Ser Glu Thr Ala Ser Gly Val Asp Val 
         515                520                525
Gly Gly Gln His Glu Trp Gly Glu Leu Val Gln Leu Asp Pro Arg Thr 
     530                535                540
Val Gly Val Ile Val Arg Leu Glu Arg Glu Thr Phe Gln Val Leu Asn 
 545                550                555                560
Met His Gly Lys Val Val Thr Val Arg His Gln Ala Val Thr Gln Lys 
                 565                570                575
Lys Asp Asn Arg Phe Ala Val Ala Leu Asp Ser Asp Gln Asn Asn Ile 
             580                585                590
His Val Lys Asp Ile Val Lys Val Ile Asp Gly Pro His Ser Gly Arg 
         595                600                605
Glu Gly Glu Ile Arg His Leu Tyr Arg Ser Phe Ala Phe Leu His Cys 
     610                615                620
Lys Lys Leu Val Glu Asn Gly Gly Met Phe Val Cys Lys Ala Arg His 
 625                630                635                640
Leu Val Leu Ala Gly Gly Ser Lys Pro Arg Asp Val Thr Asn Leu Thr 
                 645                650                655
Val Gly Gly Phe Thr Pro Met Ser Pro Arg Ile Ser Ser Pro Met His 
             660                665                670
Pro Ser Ala Glu Gly Gln His Gly Gly Phe Gly Ser Pro Gly Gly Met 
         675                680                685
Ser Arg Gly Arg Gly Arg Arg Asp Asn Glu Leu Ile Gly Gln Thr Val 
     690                695                700
Arg Ile Ser Gln Gly Pro Tyr Lys Gly Tyr Ile Gly Val Val Lys Asp 
 705                710                715                720
Ala Thr Glu Ser Thr Ala Arg Val Glu Leu His Ser Thr Cys Gln Thr 
                 725                730                735
Ile Ser Val Asp Arg Gln Arg Leu Thr Thr Val Asp Ser Gln Arg Pro 
             740                745                750
Gly Gly Met Thr Ser Thr Tyr Gly Arg Thr Pro Met Tyr Gly Ser Gln 
         755                760                765
Thr Pro Met Tyr Gly Ser Gly Ser Arg Thr Pro Met Tyr Gly Ser Gln 
     770                775                780
Thr Pro Leu Gln Asp Gly Ser Arg Thr Pro His Tyr Gly Ser Gln Thr 
 785                790                795                800
Pro Leu His Asp Gly Ser Arg Thr Pro Ala Gln Ser Gly Ala Trp Asp 
                 805                810                815
Pro Asn Asn Pro Asn Thr Pro Ser Arg Ala Glu Glu Glu Tyr Glu Tyr 
             820                825                830
Ala Phe Asp Asp Glu Pro Thr Pro Ser Pro Gln Ala Tyr Gly Gly Thr 
         835                840                845
Pro Asn Pro Gln Thr Pro Gly Tyr Pro Asp Pro Ser Ser Pro Gln Val 
     850                855                860
Asn Pro Gln Tyr Asn Pro Gln Thr Pro Gly Thr Pro Ala Met Tyr Asn 
 865                870                875                880
Thr Asp Gln Phe Ser Pro Tyr Ala Ala Pro Ser Pro Gln Gly Ser Tyr 
                 885                890                895
Gln Pro Ser Pro Ser Pro Gln Ser Tyr His Gln Val Ala Pro Ser Pro 
             900                905                910
Ala Gly Tyr Gln Asn Thr His Ser Pro Ala Ser Tyr His Pro Thr Pro 
         915                920                925
Ser Pro Met Ala Tyr Gln Ala Ser Pro Ser Pro Ser Pro Val Gly Tyr 
     930                935                940
Ser Pro Met Thr Pro Gly Ala Pro Ser Pro Gly Gly Tyr Asn Pro His 
 945                950                955                960
Thr Pro Gly Ser Gly Ile Glu Gln Asn Ser Ser Asp Trp Val Thr Thr 
                 965                970                975
Asp Ile Gln Val Lys Val Arg Asp Thr Tyr Leu Asp Thr Gln Ile Val 
             980                985                990
Gly Gln Thr Gly Val Ile Arg Ser Val Thr Gly Gly Met Cys Ser Val 
         995                1000                1005
Tyr Leu Lys Asp Ser Glu Lys Val Val Ser Ile Ser Ser Glu His Leu 
     1010                1015                1020
Glu Pro Ile Thr Pro Thr Lys Asn Asn Lys Val Lys Val Ile Leu Gly 
 1025                1030                1035                1040
Glu Asp Arg Glu Ala Thr Gly Val Leu Leu Ser Ile Asp Gly Glu Asp 
                 1045                1050                1055
Gly Ile Ile Arg Met Asp Leu Glu Asp Gln Gln Ile Lys Ile Leu Asn 
             1060                1065                1070
Leu Arg Phe Leu Gly Lys Leu Leu Glu Ala 
         1075                1080



<210> 4923
<211> 220
<212> PRT
<213> Homo sapiens
<308> P51809
<400> 4923

Met Ala Ile Leu Phe Ala Val Val Ala Arg Gly Thr Thr Ile Leu Ala 
  1               5                  10                  15
Lys His Ala Trp Cys Gly Gly Asn Phe Leu Glu Val Thr Glu Gln Ile 
             20                  25                  30
Leu Ala Lys Ile Pro Ser Glu Asn Asn Lys Leu Thr Tyr Ser His Gly 
         35                  40                  45
Asn Tyr Leu Phe His Tyr Ile Cys Gln Asp Arg Ile Val Tyr Leu Cys 
     50                  55                  60
Ile Thr Asp Asp Asp Phe Glu Arg Ser Arg Ala Phe Asn Phe Leu Asn 
 65                  70                  75                  80
Glu Ile Lys Lys Arg Phe Gln Thr Thr Tyr Gly Ser Arg Ala Gln Thr 
                 85                  90                  95
Ala Leu Pro Tyr Ala Met Asn Ser Glu Phe Ser Ser Val Leu Ala Ala 
             100                105                110
Gln Leu Lys His His Ser Glu Asn Lys Gly Leu Asp Lys Val Met Glu 
         115                120                125
Thr Gln Ala Gln Val Asp Glu Leu Lys Gly Ile Met Val Arg Asn Ile 
     130                135                140
Asp Leu Val Ala Gln Arg Gly Glu Arg Leu Glu Leu Leu Ile Asp Lys 
 145                150                155                160
Thr Glu Asn Leu Val Asp Ser Ser Val Thr Phe Lys Thr Thr Ser Arg 
                 165                170                175
Asn Leu Ala Arg Ala Met Cys Met Lys Asn Leu Lys Leu Thr Ile Ile 
             180                185                190
Ile Ile Ile Val Ser Ile Val Phe Ile Tyr Ile Ile Val Ser Pro Leu 
         195                200                205
Cys Gly Gly Phe Thr Trp Pro Ser Cys Val Lys Lys 
     210                215                220



<210> 4924
<211> 430
<212> DNA
<213> Rattus norvegicus
<308> AA858586
<400> 4924

ttttttttt  tttttttca  gcagtttct  tttattgaa  ggcctgaac  caaaggcaa  60
ctgggacag  agaaagaag  caggacatt  ctcatactg  tctgattcc  agagtacca  120
tggaggagg  aaaggaaat  cacattgat  gccctggct  gccccatac  cagggttcc  180
tccgaggcc  atcattgcc  gatctggct  cttgctccg  gtctgcact  cacgcttgg  240
cctcaggcc  cgatcagct  ccctaagaa  cggaggttt  gaatcttga  ctgctggtc  300
tccaggtcc  ttcggctga  gccatcctc  ccatcagta  tcagaacga  ccccgtacc  360
actcggtcc  cacccagaa  cactttcac  ttgttgttc  tggtagcgg  catgggctc  420
agatgctcac  430



<210> 4925
<211> 1082
<212> PRT
<213> Rattus norvegicus
<308> AAC40052
<400> 4925

Met Ser Asp Ser Glu Asp Ser Asn Phe Ser Glu Glu Glu Asp Ser Glu 
  1               5                  10                  15
Arg Ser Ser Glu Ala Glu Glu Ala Glu Val Glu Glu Asp Gln Arg Ser 
             20                  25                  30
Ala Ala Gly Ser Glu Lys Glu Glu Glu Pro Glu Glu Glu Glu Glu Glu 
         35                  40                  45
Glu Glu Glu Tyr Asp Glu Glu Glu Glu Glu Glu Asp Asp Asp Arg Pro 
     50                  55                  60
Pro Lys Lys Pro Arg His Gly Gly Phe Ile Leu Asp Glu Ala Asp Val 
 65                  70                  75                  80
Asp Asp Glu Tyr Glu Asp Glu Asp Gln Trp Glu Asp Gly Ala Glu Asp 
                 85                  90                  95
Ile Leu Glu Lys Glu Glu Ile Glu Ala Ser Asn Ile Asp Asn Val Val 
             100                105                110
Leu Asp Glu Asp Arg Ser Gly Ala Arg Arg Leu Gln Asn Leu Trp Arg 
         115                120                125
Asp Gln Arg Glu Glu Glu Leu Gly Glu Tyr Tyr Met Lys Lys Tyr Ala 
     130                135                140
Lys Ser Ser Val Gly Glu Thr Val Tyr Gly Gly Ser Asp Glu Leu Ser 
 145                150                155                160
Asp Asp Ile Thr Gln Gln Gln Leu Leu Pro Gly Val Lys Asp Pro Asn 
                 165                170                175
Leu Trp Thr Val Lys Cys Lys Ile Gly Glu Glu Arg Ala Thr Ala Ile 
             180                185                190
Ser Leu Met Arg Lys Phe Ile Ala Tyr Gln Phe Thr Asp Thr Pro Leu 
         195                200                205
Gln Ile Lys Ser Val Val Ala Pro Glu His Val Lys Gly Tyr Ile Tyr 
     210                215                220
Val Glu Ala Tyr Lys Gln Thr His Val Lys Gln Ala Ile Glu Gly Val 
 225                230                235                240
Gly Asn Leu Arg Leu Gly Tyr Trp Asn Gln Gln Met Val Pro Ile Lys 
                 245                250                255
Glu Met Thr Asp Val Leu Lys Val Val Lys Glu Val Ala Asn Leu Lys 
             260                265                270
Pro Lys Ser Trp Val Arg Leu Lys Arg Gly Ile Tyr Lys Asp Asp Ile 
         275                280                285
Ala Gln Val Asp Tyr Val Glu Pro Ser Gln Asn Thr Ile Ser Leu Lys 
     290                295                300
Met Ile Pro Arg Ile Asp Tyr Asp Arg Ile Lys Ala Arg Met Ser Leu 
 305                310                315                320
Lys Asp Trp Phe Ala Lys Arg Lys Lys Phe Lys Arg Pro Pro Gln Arg 
                 325                330                335
Leu Phe Asp Ala Glu Lys Ile Arg Ser Leu Gly Gly Asp Val Ala Ser 
             340                345                350
Asp Gly Asp Phe Leu Ile Phe Glu Gly Asn Arg Tyr Ser Arg Lys Gly 
         355                360                365
Phe Leu Phe Lys Ser Phe Ala Met Ser Ala Val Ile Thr Glu Gly Val 
     370                375                380
Lys Pro Thr Leu Ser Glu Leu Glu Lys Phe Glu Asp Gln Pro Glu Gly 
 385                390                395                400
Ile Asp Leu Glu Val Val Thr Glu Ser Thr Gly Lys Glu Arg Glu His 
                 405                410                415
Asn Phe Gln Pro Gly Asp Asn Val Glu Val Cys Glu Gly Glu Leu Ile 
             420                425                430
Asn Leu Gln Gly Lys Val Leu Ser Val Asp Gly Asn Lys Ile Thr Ile 
         435                440                445
Met Pro Lys His Glu Asp Leu Lys Asp Met Leu Glu Phe Pro Ala Gln 
     450                455                460
Glu Leu Arg Lys Tyr Phe Lys Met Gly Asp His Val Lys Val Ile Ala 
 465                470                475                480
Gly Arg Phe Glu Gly Asp Thr Gly Leu Ile Val Arg Val Glu Glu Asn 
                 485                490                495
Phe Val Ile Leu Phe Ser Asp Leu Thr Met His Glu Leu Lys Val Leu 
             500                505                510
Pro Arg Asp Leu Gln Leu Cys Ser Glu Thr Ala Ser Gly Val Asp Val 
         515                520                525
Gly Gly Gln His Glu Trp Gly Glu Leu Val Gln Leu Asp Pro Arg Thr 
     530                535                540
Val Gly Val Ile Val Arg Leu Glu Arg Glu Thr Phe Gln Val Leu Asn 
 545                550                555                560
Met His Gly Lys Val Val Thr Val Arg His Gln Ala Val Thr Gln Lys 
                 565                570                575
Lys Asp Asn Arg Phe Ala Val Ala Leu Asp Ser Asp Gln Asn Asn Ile 
             580                585                590
His Val Lys Asp Ile Val Lys Val Ile Asp Gly Pro His Ser Gly Arg 
         595                600                605
Glu Gly Glu Ile Arg His Leu Tyr Arg Ser Phe Ala Phe Leu His Cys 
     610                615                620
Lys Lys Leu Val Glu Asn Gly Gly Met Phe Val Cys Lys Ala Arg His 
 625                630                635                640
Leu Val Leu Ala Gly Gly Ser Lys Pro Arg Asp Val Thr Asn Leu Thr 
                 645                650                655
Val Gly Gly Phe Thr Pro Met Ser Pro Arg Ile Ser Ser Pro Met His 
             660                665                670
Pro Ser Ala Glu Gly Gln His Gly Gly Phe Gly Ser Pro Gly Gly Met 
         675                680                685
Ser Arg Gly Arg Gly Arg Arg Asp Asn Glu Leu Ile Gly Gln Thr Val 
     690                695                700
Arg Ile Ser Gln Gly Pro Tyr Lys Gly Tyr Ile Gly Val Val Lys Asp 
 705                710                715                720
Ala Thr Glu Ser Thr Ala Arg Val Glu Leu His Ser Thr Cys Gln Thr 
                 725                730                735
Ile Ser Val Asp Arg Gln Arg Leu Thr Thr Val Asp Ser Gln Arg Pro 
             740                745                750
Gly Gly Met Thr Ser Thr Tyr Gly Arg Thr Pro Met Tyr Gly Ser Gln 
         755                760                765
Thr Pro Met Tyr Gly Ser Gly Ser Arg Thr Pro Met Tyr Gly Ser Gln 
     770                775                780
Thr Pro Leu Gln Asp Gly Ser Arg Thr Pro His Tyr Gly Ser Gln Thr 
 785                790                795                800
Pro Leu His Asp Gly Ser Arg Thr Pro Ala Gln Ser Gly Ala Trp Asp 
                 805                810                815
Pro Asn Asn Pro Asn Thr Pro Ser Arg Ala Glu Glu Glu Tyr Glu Tyr 
             820                825                830
Ala Phe Asp Asp Glu Pro Thr Pro Ser Pro Gln Ala Tyr Gly Gly Thr 
         835                840                845
Pro Asn Pro Gln Thr Pro Gly Tyr Pro Asp Pro Ser Ser Pro Gln Val 
     850                855                860
Asn Pro Gln Tyr Asn Pro Gln Thr Pro Gly Thr Pro Ala Met Tyr Asn 
 865                870                875                880
Thr Asp Gln Phe Ser Pro Tyr Ala Ala Pro Ser Pro Gln Gly Ser Tyr 
                 885                890                895
Gln Pro Ser Pro Ser Pro Gln Ser Tyr His Gln Val Ala Pro Ser Pro 
             900                905                910
Ala Gly Tyr Gln Asn Thr His Ser Pro Ala Ser Tyr His Pro Thr Pro 
         915                920                925
Ser Pro Met Ala Tyr Gln Ala Ser Pro Ser Pro Ser Pro Val Gly Tyr 
     930                935                940
Ser Pro Met Thr Pro Gly Ala Pro Ser Pro Gly Gly Tyr Asn Pro His 
 945                950                955                960
Thr Pro Gly Ser Gly Ile Glu Gln Asn Ser Ser Asp Trp Val Thr Thr 
                 965                970                975
Asp Ile Gln Val Lys Val Arg Asp Thr Tyr Leu Asp Thr Gln Ile Val 
             980                985                990
Gly Gln Thr Gly Val Ile Arg Ser Val Thr Gly Gly Met Cys Ser Val 
         995                1000                1005
Tyr Leu Lys Asp Ser Glu Lys Val Val Ser Ile Ser Ser Glu His Leu 
     1010                1015                1020
Glu Pro Ile Thr Pro Thr Lys Asn Asn Lys Val Lys Val Ile Leu Gly 
 1025                1030                1035                1040
Glu Asp Arg Glu Ala Thr Gly Val Leu Leu Ser Ile Asp Gly Glu Asp 
                 1045                1050                1055
Gly Ile Ile Arg Met Asp Leu Glu Asp Gln Gln Ile Lys Ile Leu Asn 
             1060                1065                1070
Leu Arg Phe Leu Gly Lys Leu Leu Glu Ala 
         1075                1080



<210> 4927
<211> 220
<212> PRT
<213> Homo sapiens
<308> P51809
<400> 4927

Met Ala Ile Leu Phe Ala Val Val Ala Arg Gly Thr Thr Ile Leu Ala 
  1               5                  10                  15
Lys His Ala Trp Cys Gly Gly Asn Phe Leu Glu Val Thr Glu Gln Ile 
             20                  25                  30
Leu Ala Lys Ile Pro Ser Glu Asn Asn Lys Leu Thr Tyr Ser His Gly 
         35                  40                  45
Asn Tyr Leu Phe His Tyr Ile Cys Gln Asp Arg Ile Val Tyr Leu Cys 
     50                  55                  60
Ile Thr Asp Asp Asp Phe Glu Arg Ser Arg Ala Phe Asn Phe Leu Asn 
 65                  70                  75                  80
Glu Ile Lys Lys Arg Phe Gln Thr Thr Tyr Gly Ser Arg Ala Gln Thr 
                 85                  90                  95
Ala Leu Pro Tyr Ala Met Asn Ser Glu Phe Ser Ser Val Leu Ala Ala 
             100                105                110
Gln Leu Lys His His Ser Glu Asn Lys Gly Leu Asp Lys Val Met Glu 
         115                120                125
Thr Gln Ala Gln Val Asp Glu Leu Lys Gly Ile Met Val Arg Asn Ile 
     130                135                140
Asp Leu Val Ala Gln Arg Gly Glu Arg Leu Glu Leu Leu Ile Asp Lys 
 145                150                155                160
Thr Glu Asn Leu Val Asp Ser Ser Val Thr Phe Lys Thr Thr Ser Arg 
                 165                170                175
Asn Leu Ala Arg Ala Met Cys Met Lys Asn Leu Lys Leu Thr Ile Ile 
             180                185                190
Ile Ile Ile Val Ser Ile Val Phe Ile Tyr Ile Ile Val Ser Pro Leu 
         195                200                205
Cys Gly Gly Phe Thr Trp Pro Ser Cys Val Lys Lys 
     210                215                220



<210> 4928
<211> 504
<212> DNA
<213> Rattus norvegicus
<308> AA858607
<400> 4928

ttttttttt  tttttttgg  tgtttaagt  agtgtcttg  ttcccccac  ctctgttaa  60
agaaatctt  tgtcatcca  gagcatgaa  caggtaatt  aactaagta  tacctcttt  120
gaataaaag  tgtactgtt  taaattgtg  tgctgtgtg  ctatgtgtg  gtgtgtgta  180
tccagtgca  gtgaccttg  aggctanag  tatttgatc  cctggagct  gagttctgg  240
catatgtgc  tgtctgacc  cttgcgggt  ctgaacttg  gtcctctgc  agagcagtc  300
tcttacaag  tgagccatc  tctggtgca  agacatgtt  tgttgttgt  gtagtttgt  360
tttatgcca  agtaccgtg  tacatccca  agaggacgc  ggcagcagc  ccaggagct  420
caagataca  aatgccgga  gagggcttg  attgcggct  gcacagggt  aagtcttac  480
aaaaagagc  caacatatg  gaaa  504



<210> 4929
<211> 563
<212> DNA
<213> Rattus norvegicus
<308> AA858617
<400> 4929

ttttttttt  tttttttag  agaagcaaa  atatatttc  gaaattcta  acaacagac  60
aacaatcaa  ccccccaaa  actgaagag  tgtcatgga  acactcaag  agacccata  120
catacattt  cttctgtgg  tcttctaag  gcagaaaag  ctagaaaga  tgagagttt  180
tttttcccc  acagaggga  cttcaatca  gaaaaagta  aataaattc  tattgctaa  240
atatgaata  agttaaaaa  atgataaat  agtttccct  ggtaattcc  gggcatttg  300
aagcaagta  ggctaacca  ggcccatca  cgcttctaa  taaaacata  agagtccct  360
gctgtttga  actgtcctg  caggggcag  attcctcgc  gggagcttt  cccactcag  420
gccaaaccc  ttctcccaa  tgtcctcag  ggacaggct  caccgctta  gcccattct  480
catggacat  tgggagagg  tatggagga  agaaagaga  ggggcaatg  ttccatact  540
gctgagact  gaaactgtc  tta  563



<210> 4930
<211> 214
<212> PRT
<213> Rattus norvegicus
<308> NP_075764
<400> 4930

Met Ser Cys Arg Glu Arg Thr Asp Ser Ser Cys Gly Cys Asn Gly His 
  1               5                  10                  15
Glu Glu Asn Arg Ile Leu Lys Cys Val Val Val Gly Asp Gly Ala Val 
             20                  25                  30
Gly Lys Thr Cys Leu Leu Met Ser Tyr Ala Asn Asp Ala Phe Pro Glu 
         35                  40                  45
Glu Tyr Val Pro Thr Val Phe Asp His Tyr Ala Val Thr Val Thr Val 
     50                  55                  60
Gly Gly Lys Gln His Leu Leu Gly Leu Tyr Asp Thr Ala Gly Gln Glu 
 65                  70                  75                  80
Asp Tyr Asn Gln Leu Arg Pro Leu Ser Tyr Pro Asn Thr Asp Val Phe 
                 85                  90                  95
Leu Ile Cys Phe Ser Val Val Asn Pro Ala Ser Tyr His Asn Val Gln 
             100                105                110
Glu Glu Trp Val Pro Glu Leu Lys Asp Cys Met Pro His Val Pro Tyr 
         115                120                125
Val Leu Ile Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Lys Thr Leu 
     130                135                140
Ala Arg Leu Leu Tyr Met Lys Glu Lys Pro Leu Thr Tyr Glu His Gly 
 145                150                155                160
Val Lys Leu Ala Lys Ala Ile Gly Ala Gln Cys Tyr Leu Glu Cys Ser 
                 165                170                175
Ala Leu Thr Gln Lys Gly Leu Lys Ala Val Phe Asp Glu Ala Ile Leu 
             180                185                190
Thr Ile Phe His Pro Lys Lys Lys Lys Lys Gly Cys Leu Gly Cys His 
         195                200                205
Gly Cys Cys Ala Ile Ile 
     210



<210> 4931
<211> 1671
<212> DNA
<213> Homo sapiens
<308> AK027278
<400> 4931

cattaaaaa  cccagcttt  ctccatgtt  gatgtgact  ggaaaatga  aaagattta  60
caaaattcc  ccgtatctt  tgccaggct  gagacaggg  gagcagggt  aaaccctca  120
gctgctgaa  tttctaggc  gttaggaag  ccctcgaat  ctgtgaaaa  gagggtttc  180
taactcaca  tgagagcgg  aaggggcag  cccttttca  aactccctc  agtgtgtgt  240
acctttctt  accagcatg  taagcaaca  gacatatcc  agcctcgga  atgtctgta  300
gatccaagg  acccaaagt  agacagagt  aactcaagc  tggcactgg  tttctgccg  360
ttcatgtgc  ttggaaaaa  caggagaag  aatagcagc  ggagtcccc  gcagctgga  420
ccgcaagaa  gaaccgcaa  gagggaact  acagcagct  cggctgcag  ggcaacgac  480
agaagaaga  gttgaagtg  gtggtggtg  gggacggtg  cgtggggaa  acctgcctg  540
tgatgagct  cgccaacga  gccttccca  aggaatacg  gcccactgt  tttgaccac  600
atgcagtta  tgtgactgt  ggaggcaag  aacacttgc  cggactgta  gacaccgcg  660
gacaggagg  ctacaacca  ctgaggcca  tctcctacc  caacacgga  gtgtttttg  720
tctgcttct  tgtcgtaaa  cctgcctct  accacaatg  ccagattga  ctccgtgat  780
acccaaaaa  ccttggccc  tttgctgta  atgaaagag  aacctctca  ttacgagca  840
ggtgtgaag  tcgcaaaag  gatcggagc  cagtgctac  tggaatgtt  agctctgac  900
cagaaaggt  tcaaagcgg  ttttgatga  gcaatcctc  ccattttcc  ccccaagaa  960
aagaagaaa  gctgttctg  gggtcacag  tgctgttca  ttatctgag  ttgtctggg  1020
cctgcctcc  ccccatcca  ggatgagaa  ggcagccaa  ctctgtggc  aagctccag  1080
caaaaagga  ggcacgacc  gaaagaacc  gtcaaaaaa  aaaaaaaaa  aacctacat  1140
tcaagtact  tttcccttc  ctcccatct  attgctaaa  attttcttt  atacgcaca  1200
actccagtg  ctggaaaaa  gggagtttt  agtcaaagc  tgacattta  agaaaacaa  1260
gactttctg  ctttataaa  ggaaatcaa  tgtgtatga  ctataactc  gcagaggtt  1320
tgaattcat  ctttacaaa  aataatgaa  ttttagtcc  gtaataaat  aaatgttat  1380
aggcagctt  gttgcatga  tgcatagtt  tatcttgct  acgggccac  catttctca  1440
tgatgtgga  gaaaaaatg  gagcagtat  tttccaggt  tgtgcactc  acaggcaaa  1500
agctcccga  gtcaccact  ccctaatgg  ccacaggaa  taagttgat  atgatgggg  1560
gatcacgtc  cccagaacc  gcaactgga  agagactgt  gttagcgtc  gggtagagc  1620
caggcttcc  ggggtctta  gagctaatt  ctgaataaa  caatctaga  c  1671



<210> 4932
<211> 166
<212> PRT
<213> Homo sapiens
<308> AK027278
<400> 4932

Met Asn Arg Lys Glu Gly Thr Asp Ser Ser Cys Gly Cys Arg Gly Asn 
  1               5                  10                  15
Asp Glu Lys Lys Met Leu Lys Cys Val Val Val Gly Asp Gly Ala Val 
             20                  25                  30
Gly Lys Thr Cys Leu Leu Met Ser Tyr Ala Asn Asp Ala Phe Pro Glu 
         35                  40                  45
Glu Tyr Val Pro Thr Val Phe Asp His Tyr Ala Val Thr Val Thr Val 
     50                  55                  60
Gly Gly Lys Gln His Leu Leu Gly Leu Tyr Asp Thr Ala Gly Gln Glu 
 65                  70                  75                  80
Asp Tyr Asn Gln Leu Arg Pro Leu Ser Tyr Pro Asn Thr Asp Val Phe 
                 85                  90                  95
Leu Ile Cys Phe Ser Val Val Asn Pro Ala Ser Tyr His Asn Val Gln 
             100                105                110
Ile Asp Leu Arg Asp Asp Pro Lys Asn Leu Gly Pro Phe Ala Val Tyr 
         115                120                125
Glu Arg Glu Thr Ser His Leu Arg Ala Trp Cys Glu Ala Arg Lys Ser 
     130                135                140
Asp Arg Ser Thr Val Leu Leu Gly Met Phe Ser Ser Asp Ser Glu Arg 
 145                150                155                160
Ser Gln Ser Gly Phe Ter 
                 165



<210> 4934
<211> 537
<212> DNA
<213> Rattus norvegicus
<308> AA858879
<400> 4934

ttttttttt  tttttttga  caatgcaaa  gcatttatt  tagaagcac  ctcagacca  60
actggaaag  tccactcag  tggatttgg  tggagacta  tctgtcccc  ttcccattc  120
tgcccttcc  catcaccta  gcctggagc  cccctccca  ggcttgcgg  ctacaaaag  180
ccccacaca  gagccttct  caagtagta  acccccatc  gtgacagat  tctgcattt  240
tagcaagaa  agttcccac  cctagcagg  tcccaaact  catcccaaa  gaatacaga  300
ctctgctga  ggtttcggg  gtcaccttg  agggtgagg  agggtgagg  gggtctgca  360
gaccctggg  cgttaggtg  ggatgtctt  agcctggtg  tctaccagc  gctccatgc  420
cttcacatc  gtgcaccag  gctccagac  gtccttcat  cccttgatc  gctgcaaat  480
cagcactcg  ggctgcacc  acgtcatgt  aacccgctt  tccacctcg  ctatgct  537



<210> 4935
<211> 376
<212> PRT
<213> Rattus norvegicus
<308> NP_036005
<400> 4935

Met Lys Asp Val Pro Ala Phe Leu Gln Gln Ser Gln Ser Ser Gly Pro 
  1               5                  10                  15
Gly Gln Ala Ala Val Trp His Arg Leu Glu Glu Leu Tyr Thr Lys Lys 
             20                  25                  30
Leu Trp His Gln Leu Thr Leu Glu Val Leu Asp Phe Val Gln Asp Pro 
         35                  40                  45
Cys Phe Ala Gln Gly Asp Gly Leu Ile Lys Leu Tyr Glu Asn Phe Ile 
     50                  55                  60
Ser Glu Phe Glu His Arg Val Asn Pro Leu Ser Leu Val Glu Ile Ile 
 65                  70                  75                  80
Leu His Val Val Arg Gln Met Thr Asp Pro Asn Val Ala Leu Thr Phe 
                 85                  90                  95
Leu Glu Lys Thr Arg Glu Lys Val Lys Ser Ser Asp Glu Ala Val Ile 
             100                105                110
Leu Cys Lys Thr Ala Ile Gly Ala Leu Lys Leu Asn Ile Gly Asp Leu 
         115                120                125
Gln Ala Thr Lys Glu Thr Ile Glu Asp Val Glu Glu Met Leu Asn Asn 
     130                135                140
Leu Pro Gly Val Thr Ser Val His Ser Arg Phe Tyr Asp Leu Ser Ser 
 145                150                155                160
Lys Tyr Tyr Gln Thr Ile Gly Asn His Ala Ser Tyr Tyr Lys Asp Ala 
                 165                170                175
Leu Arg Phe Leu Gly Cys Val Asp Ile Lys Asp Leu Pro Val Ser Glu 
             180                185                190
Gln Gln Glu Arg Ala Phe Thr Leu Gly Leu Ala Gly Leu Leu Gly Glu 
         195                200                205
Gly Val Phe Asn Phe Gly Glu Leu Leu Met His Pro Val Leu Glu Ser 
     210                215                220
Leu Arg Asp Thr Asp Arg Gln Trp Leu Ile Asp Thr Leu Tyr Ala Phe 
 225                230                235                240
Asn Ser Gly Ala Val Asp Arg Phe Gln Thr Leu Lys Cys Ala Trp Gly 
                 245                250                255
Gln Gln Pro Asp Leu Ala Ala Asn Glu Ala Gln Leu Leu Arg Lys Ile 
             260                265                270
Gln Leu Leu Cys Leu Met Glu Met Thr Phe Thr Arg Pro Ala Asn His 
         275                280                285
Arg Gln Leu Thr Phe Glu Glu Ile Ala Lys Ser Ala Lys Ile Thr Val 
     290                295                300
Asn Lys Val Glu Leu Leu Val Met Lys Ala Leu Ser Val Gly Leu Val 
 305                310                315                320
Arg Gly Ser Ile Asp Glu Val Asp Lys Arg Val His Met Thr Trp Val 
                 325                330                335
Gln Pro Arg Val Leu Asp Leu Gln Gln Ile Lys Gly Met Lys Asp Arg 
             340                345                350
Leu Glu Leu Trp Cys Thr Asp Val Lys Ser Met Glu Met Leu Val Glu 
         355                360                365
His Gln Ala Gln Asp Ile Leu Thr 
     370                375



<210> 4936
<211> 1584
<212> DNA
<213> Homo sapiens
<308> AB009398
<400> 4936

tttccggca  ccatccccg  ggtgctgac  tcccggttg  tcttctgtg  cgggggtct  60
cctgctgtc  tgaaggacg  accgggctt  ctacagcag  gccagaact  cgggcccgg  120
cagcccgct  tgtggcacc  tctggagga  ctctacacg  agaagttgt  gcatcagct  180
acacttcag  tgcttgatt  tgtgcagga  ccgtgcttt  cccaaggag  tggtctcat  240
aagctttat  aaaacttta  cagtgaatt  gaacacagg  tgaaccctt  gtccctcgt  300
gaaatcatt  ttcatgtag  tagacagat  actgatcct  atgtggctc  tacttttct  360
gaaaagact  gtgagaagg  gaaaagtag  gatgaggca  tgatcctgt  taaaacagc  420
attggagct  taaaattaa  catcgggga  ctacaggtt  caaaggaaa  aattgaaga  480
gttgaagaa  tgctcaaca  ccttcctgg  gtgacatcg  ttcacagtc  tttctatga  540
ctctccagt  aatactatc  aacaatcgg  aaccacgcg  cctactaca  agatgctct  600
cggtttttg  gctgtgttg  catcaagga  ctaccagtg  ctgagcagc  ggagagagc  660
ttcacgctg  ggctagcag  acttctcgg  gagggagtt  ttaactttg  agaactcct  720
atgcaccct  tgctggagt  cctgaggaa  actgaccgg  agtggctga  tgacaccct  780
tatgccttc  acagtggca  cgtagagcg  ttccagact  tgaagactg  ctggggcca  840
cagcctgat  tagcagcta  tgaagccca  cttctgagg  aaattcagt  gttgtgcct  900
atggagatg  ctttcacac  acctgccaa  cacagacaa  tcacttttg  agaaattgc  960
aaaagtgct  aaatcacag  gaatgaggt  gagcttctg  tgatgaagg  cctttcggt  1020
gggctggtg  aaggcagta  agacgaggt  gacaaacga  tccacatga  ctgggtgca  1080
ccccgagtg  tggatttgc  acagatcaa  ggaatgaag  accgcctgg  gttctggtg  1140
acggatgtg  agagcatgg  gatgctggt  gagcaccag  cccatgaca  cctcaccta  1200
ggccccctg  ttccccgtc  tgtctcctt  gactcacct  agagaggcg  ttgcagcca  1260
tgaagctgg  tgctcagac  gtcgacatt  aatttgggt  ggggttggg  tcctgtctg  1320
agtacagac  gttcttgct  taaaaacag  actgtccct  atgggagcc  ggccacagg  1380
aggaggctt  tttgtgggt  tctcctgca  agggtgggg  tctcagggt  ttaggtgat  1440
cgggagaga  agaacgtgc  aggcaggag  ccccctgaa  tctgtgtac  ccgaggtgg  1500
tctccatcc  catccacct  tacggacat  ttttccgtt  cggtttgag  atgttccta  1560
aataaaccc  tctgctttg  taac  1584



<210> 4937
<211> 376
<212> PRT
<213> Homo sapiens
<308> Q9UNM6
<400> 4937

Met Lys Asp Val Pro Gly Phe Leu Gln Gln Ser Gln Ser Ser Gly Pro 
  1               5                  10                  15
Gly Gln Pro Ala Val Trp His Arg Leu Glu Glu Leu Tyr Thr Lys Lys 
             20                  25                  30
Leu Trp His Gln Leu Thr Leu Gln Val Leu Asp Phe Val Gln Asp Pro 
         35                  40                  45
Cys Phe Ala Gln Gly Asp Gly Leu Ile Lys Leu Tyr Glu Asn Phe Ile 
     50                  55                  60
Ser Glu Phe Glu His Arg Val Asn Pro Leu Ser Leu Val Glu Ile Ile 
 65                  70                  75                  80
Leu His Val Val Arg Gln Met Thr Asp Pro Asn Val Ala Leu Thr Phe 
                 85                  90                  95
Leu Glu Lys Thr Arg Glu Lys Val Lys Ser Ser Asp Glu Ala Val Ile 
             100                105                110
Leu Cys Lys Thr Ala Ile Gly Ala Leu Lys Leu Asn Ile Gly Asp Leu 
         115                120                125
Gln Val Thr Lys Glu Thr Ile Glu Asp Val Glu Glu Met Leu Asn Asn 
     130                135                140
Leu Pro Gly Val Thr Ser Val His Ser Arg Phe Tyr Asp Leu Ser Ser 
 145                150                155                160
Lys Tyr Tyr Gln Thr Ile Gly Asn His Ala Ser Tyr Tyr Lys Asp Ala 
                 165                170                175
Leu Arg Phe Leu Gly Cys Val Asp Ile Lys Asp Leu Pro Val Ser Glu 
             180                185                190
Gln Gln Glu Arg Ala Phe Thr Leu Gly Leu Ala Gly Leu Leu Gly Glu 
         195                200                205
Gly Val Phe Asn Phe Gly Glu Leu Leu Met His Pro Val Leu Glu Ser 
     210                215                220
Leu Arg Asn Thr Asp Arg Gln Trp Leu Ile Asp Thr Leu Tyr Ala Phe 
 225                230                235                240
Asn Ser Gly Asn Val Glu Arg Phe Gln Thr Leu Lys Thr Ala Trp Gly 
                 245                250                255
Gln Gln Pro Asp Leu Ala Ala Asn Glu Ala Gln Leu Leu Arg Lys Ile 
             260                265                270
Gln Leu Leu Cys Leu Met Glu Met Thr Phe Thr Arg Pro Ala Asn His 
         275                280                285
Arg Gln Leu Thr Phe Glu Glu Ile Ala Lys Ser Ala Lys Ile Thr Val 
     290                295                300
Asn Glu Val Glu Leu Leu Val Met Lys Ala Leu Ser Val Gly Leu Val 
 305                310                315                320
Lys Gly Ser Ile Asp Glu Val Asp Lys Arg Val His Met Thr Trp Val 
                 325                330                335
Gln Pro Arg Val Leu Asp Leu Gln Gln Ile Lys Gly Met Lys Asp Arg 
             340                345                350
Leu Glu Phe Trp Cys Thr Asp Val Lys Ser Met Glu Met Leu Val Glu 
         355                360                365
His Gln Ala His Asp Ile Leu Thr 
     370                375



<210> 4938
<211> 433
<212> DNA
<213> Rattus norvegicus
<308> AA859483
<400> 4938

ttttttttt  tttttttaa  tgtttatga  ttttattat  actgtgttt  tttaaatat  60
tatatatat  tttatagct  tatgcatcc  ccgcaccac  cccccaagc  cctagttct  120
gcccttagc  ttctgtttg  tggctgtgt  gggcagcac  gtctgcgtg  tcttgtctg  180
tactgtctg  gtgctgctg  tccttgtga  cctccgggt  tgttctggg  ccaacgtgg  240
gacacagga  ggcaagggg  ggggccttg  gcccaagaa  agcttccag  acttgaagt  300
ccaatggtg  acagagctg  tctttgcct  aatctggat  cggaggcag  gggatgatt  360
tgcaaggac  aagggtaag  gatgccctt  ggatggggg  aggcatcaa  cccctcgca  420
ctcctaggc  gtt  433



<210> 4939
<211> 216
<212> DNA
<213> Homo sapiens
<308> AW905020
<400> 4939

cgttgtcag  ggtggtgag  gggagcgga  tcgacagcg  atgaagatg  tcatcgggc  60
gcttgaggg  atccttcgc  agctcaagg  ggtggccaa  gagctgagg  aggtggtga  120
ccagatcga  aagctaacc  cggacttcg  ctttgaact  gagccggac  actggacca  180
ggccactgt  agcagcacc  ctagcactg  caacgg  216



<210> 4940
<211> 499
<212> DNA
<213> Rattus norvegicus
<308> AA859524
<400> 4940

ttttttttt  tttttttga  gcaaacgca  gagatttat  tttccagcg  attggggtc  60
accttctat  agcccctcg  gtcgagtga  tgtcgggct  taacacagt  tttatactt  120
ttaggggta  aggttatgt  agaaaggtt  cagtttaaa  ttattggct  agcatattg  180
cctttgaat  tattggcta  caagcatat  acatacatt  gaactctat  tggaaccag  240
aggtcaggt  actatcagt  agtacattc  gtggttttt  aagaatgtc  ctgctcctc  300
tgagaactg  gggcggaga  tggaactta  cctagcctt  acctgaagt  ggaagctgg  360
acttggcct  atcttgacc  gaggtggtg  gtataaggc  ggtgaaagc  tctaaagtc  420
ttcacacgt  ccccataat  tacctactt  ctaccaggt  aagcttctt  atagctctt  480
cacttcagt  agaatgagg  499



<210> 4941
<211> 448
<212> DNA
<213> Rattus norvegicus
<308> AA859529
<400> 4941

ttttttttt  tttttttaa  gtttttaga  agctcttta  tgatatcct  agcccctgg  60
cagcacaga  tcccagcac  ggctcatac  agctggact  aggtgccat  cccaagagc  120
ggagtaggc  ccatagggg  agagaggcc  cccagacta  gaggagtgt  caggcagcc  180
ggaagccct  cagaactcc  ggcccaggt  agggagggc  ggcctttgg  agtagctca  240
gcccccact  gggcatcat  gttgagcac  tagtagtcg  ggacataca  gagcacagc  300
accggttgc  caatgatga  tgtcaccca  acagctgca  tgccatagt  cccttggaa  360
aagcggttc  caatccagg  cagtgggac  tgagccatc  tggctgtga  tgcccagag  420
cggaacatc  tcaggggaa  gctcacta  448



<210> 4942
<211> 498
<212> PRT
<213> Rattus norvegicus
<308> Q9ERM3
<400> 4942

Met Gly Asp Arg Gly Gly Ala Gly Ser Ser Arg Arg Arg Arg Thr Gly 
  1               5                  10                  15
Ser Arg Val Ser Val Gln Gly Gly Ser Gly Pro Lys Val Glu Glu Asp 
             20                  25                  30
Glu Val Arg Glu Ala Ala Val Ser Pro Asp Leu Gly Ala Gly Gly Asp 
         35                  40                  45
Ala Pro Ala Pro Ala Pro Ala Pro Ala His Thr Arg Asp Lys Asp Arg 
     50                  55                  60
Gln Thr Ser Val Gly Asp Gly His Trp Glu Leu Arg Cys His Arg Leu 
 65                  70                  75                  80
Gln Asp Ser Leu Phe Ser Ser Asp Ser Gly Phe Ser Asn Tyr Arg Gly 
                 85                  90                  95
Ile Leu Asn Trp Cys Val Val Met Leu Ile Leu Ser Asn Ala Arg Leu 
             100                105                110
Ser Leu Glu Asn Leu Ile Lys Tyr Gly Ile Leu Val Asp Pro Ile Gln 
         115                120                125
Val Val Ser Leu Phe Leu Lys Asp Pro Tyr Ser Trp Pro Ala Pro Cys 
     130                135                140
Leu Ile Ile Ala Ser Asn Ile Phe Ile Val Ala Thr Phe Gln Ile Glu 
 145                150                155                160
Lys Arg Leu Ser Val Gly Ala Leu Thr Glu Gln Met Gly Leu Leu Leu 
                 165                170                175
His Val Val Asn Leu Ala Thr Ile Ile Cys Phe Pro Ala Ala Val Ala 
             180                185                190
Leu Leu Val Glu Ser Ile Thr Pro Val Gly Ser Leu Phe Ala Leu Ala 
         195                200                205
Ser Tyr Ser Ile Ile Phe Leu Lys Leu Ser Ser Tyr Arg Asp Val Asn 
     210                215                220
Leu Trp Cys Arg Gln Arg Arg Val Lys Ala Lys Ala Val Ser Ala Gly 
 225                230                235                240
Lys Lys Val Ser Gly Ala Ala Ala Gln Asn Thr Val Ser Tyr Pro Asp 
                 245                250                255
Asn Leu Thr Tyr Arg Asp Leu Tyr Tyr Phe Ile Phe Ala Pro Thr Leu 
             260                265                270
Cys Tyr Glu Leu Asn Phe Pro Arg Ser Pro Arg Ile Arg Lys Arg Phe 
         275                280                285
Leu Leu Arg Arg Val Leu Glu Met Leu Phe Phe Thr Gln Leu Gln Val 
     290                295                300
Gly Leu Ile Gln Gln Trp Met Val Pro Thr Ile Gln Asn Ser Met Lys 
 305                310                315                320
Pro Phe Lys Asp Met Asp Tyr Ser Arg Ile Ile Glu Arg Leu Leu Lys 
                 325                330                335
Leu Ala Val Pro Asn His Leu Ile Trp Leu Ile Phe Phe Tyr Trp Leu 
             340                345                350
Phe His Ser Cys Leu Asn Ala Val Ala Glu Leu Leu Gln Phe Gly Asp 
         355                360                365
Arg Glu Phe Tyr Arg Asp Trp Trp Asn Ala Glu Ser Val Thr Tyr Phe 
     370                375                380
Trp Gln Asn Trp Asn Ile Pro Val His Lys Trp Cys Ile Arg His Phe 
 385                390                395                400
Tyr Lys Pro Met Leu Arg Leu Gly Ser Asn Lys Trp Met Ala Arg Thr 
                 405                410                415
Gly Val Phe Trp Ala Ser Ala Phe Phe His Glu Tyr Leu Val Ser Ile 
             420                425                430
Pro Leu Arg Met Phe Arg Leu Trp Ala Phe Thr Ala Met Met Ala Gln 
         435                440                445
Val Pro Leu Ala Trp Ile Val Asn Arg Phe Phe Gln Gly Asn Tyr Gly 
     450                455                460
Asn Ala Ala Val Trp Val Thr Leu Ile Ile Gly Gln Pro Val Ala Val 
 465                470                475                480
Leu Met Tyr Val His Asp Tyr Tyr Val Leu Asn Tyr Asp Ala Pro Val 
                 485                490                495
Gly Ala 
             500



<210> 4943
<211> 863
<212> DNA
<213> Homo sapiens
<308> BI521353
<400> 4943

gaactccat  aagcccttc  aggaacatg  actactcac  catcatcga  cgcctcctg  60
agctggcgg  ccccaatca  ctcatctgg  tcatcttct  ctactggct  ttccactcc  120
gcctgaatg  cgtggctga  ctcatgcag  ttggagacc  ggagttcta  cgggactgg  180
ggaactccg  gtctgtcac  tacttctgg  agaactgga  catccctgt  cacaagtgg  240
gcatcaggt  ggtggggtg  gtgtgtgtg  gatgtggaa  atggctgtg  acctgaacc  300
ctttccatg  cccctcctc  gcagacact  ctacaagcc  atgcttcga  ggggcagca  360
caagtggat  gccaggaca  gggtgttcc  ggcctcggc  ttcttccac  agtacctgg  420
gagcgtccc  ctgcgaatg  tccgcctct  ggcgttcac  ggcatgatg  ctcagatcc  480
actggcctg  ttcgtgggc  gctttttcc  gggcaacta  ggcaacgca  ctgtgtggc  540
gtcgctcat  atcggacag  caatagccg  cctcatgta  gtccacgac  actacgtgc  600
caactatga  gccccagcg  cagaggcct  agctgcacc  gagggcctg  cttctcact  660
ccgactcac  cccgctgcc  gagcccact  tcctcctag  ccttcgagt  ctgcggatg  720
gcctggctg  acagtatcc  cctctggtc  caggggagg  ctctctgcc  taatggggc  780
ctgtcctgc  cccctcagg  atggcaaca  caggccaga  acagtctga  gccagctgg  840
agtcttgct  gaaccttgc  ccg  863



<210> 4944
<211> 488
<212> PRT
<213> Homo sapiens
<308> XP_035370
<400> 4944

Met Gly Asp Arg Gly Ser Ser Arg Arg Arg Arg Thr Gly Ser Arg Pro 
  1               5                  10                  15
Ser Ser His Gly Gly Gly Gly Pro Ala Ala Ala Glu Glu Glu Val Arg 
             20                  25                  30
Asp Ala Ala Ala Gly Pro Asp Val Gly Ala Ala Gly Asp Ala Pro Ala 
         35                  40                  45
Pro Ala Pro Asn Lys Asp Gly Asp Ala Gly Val Gly Ser Gly His Trp 
     50                  55                  60
Glu Leu Arg Cys His Arg Leu Gln Asp Ser Leu Phe Ser Ser Asp Ser 
 65                  70                  75                  80
Gly Phe Ser Asn Tyr Arg Gly Ile Leu Asn Trp Cys Val Val Met Leu 
                 85                  90                  95
Ile Leu Ser Asn Ala Arg Leu Phe Leu Glu Asn Leu Ile Lys Tyr Gly 
             100                105                110
Ile Leu Val Asp Pro Ile Gln Val Val Ser Leu Phe Leu Lys Asp Pro 
         115                120                125
Tyr Ser Trp Pro Ala Pro Cys Leu Val Ile Ala Ala Asn Val Phe Ala 
     130                135                140
Val Ala Ala Phe Gln Val Glu Lys Arg Leu Ala Val Gly Ala Leu Thr 
 145                150                155                160
Glu Gln Ala Gly Leu Leu Leu His Val Ala Asn Leu Ala Thr Ile Leu 
                 165                170                175
Cys Phe Pro Ala Ala Val Val Leu Leu Val Glu Ser Ile Thr Pro Val 
             180                185                190
Gly Ser Leu Leu Ala Leu Met Ala His Thr Ile Leu Phe Leu Lys Leu 
         195                200                205
Phe Ser Tyr Arg Asp Val Asn Ser Trp Cys Arg Arg Ala Arg Ala Lys 
     210                215                220
Ala Ala Ser Ala Gly Lys Lys Ala Ser Ser Ala Ala Ala Pro His Thr 
 225                230                235                240
Val Ser Tyr Pro Asp Asn Leu Thr Tyr Arg Asp Leu Tyr Tyr Phe Leu 
                 245                250                255
Phe Ala Pro Thr Leu Cys Tyr Glu Leu Asn Phe Pro Arg Ser Pro Arg 
             260                265                270
Ile Arg Lys Arg Phe Leu Leu Arg Arg Ile Leu Glu Met Leu Phe Phe 
         275                280                285
Thr Gln Leu Gln Val Gly Leu Ile Gln Gln Trp Met Val Pro Thr Ile 
     290                295                300
Gln Asn Ser Met Lys Pro Phe Lys Asp Met Asp Tyr Ser Arg Ile Ile 
 305                310                315                320
Glu Arg Leu Leu Lys Leu Ala Val Pro Asn His Leu Ile Trp Leu Ile 
                 325                330                335
Phe Phe Tyr Trp Leu Phe His Ser Cys Leu Asn Ala Val Ala Glu Leu 
             340                345                350
Met Gln Phe Gly Asp Arg Glu Phe Tyr Arg Asp Trp Trp Asn Ser Glu 
         355                360                365
Ser Val Thr Tyr Phe Trp Gln Asn Trp Asn Ile Pro Val His Lys Trp 
     370                375                380
Cys Ile Arg His Phe Tyr Lys Pro Met Leu Arg Arg Gly Ser Ser Lys 
 385                390                395                400
Trp Met Ala Arg Thr Gly Val Phe Leu Ala Ser Ala Phe Phe His Glu 
                 405                410                415
Tyr Leu Val Ser Val Pro Leu Arg Met Phe Arg Leu Trp Ala Phe Thr 
             420                425                430
Gly Met Met Ala Gln Ile Pro Leu Ala Trp Phe Val Gly Arg Phe Phe 
         435                440                445
Gln Gly Asn Tyr Gly Asn Ala Ala Val Trp Leu Ser Leu Ile Ile Gly 
     450                455                460
Gln Pro Ile Ala Val Leu Met Tyr Val His Asp Tyr Tyr Val Leu Asn 
 465                470                475                480
Tyr Glu Ala Pro Ala Ala Glu Ala 
                 485



<210> 4945
<211> 557
<212> DNA
<213> Rattus norvegicus
<308> AA859581
<400> 4945

ttttttttt  tttttttag  aaccatttg  acttttgct  atgtggatg  gtgtggcgt  60
tgtggagat  atggatctc  tagagttag  cataggtgg  ttatagtta  agtctgtga  120
tcgtgggaa  tgagctcag  tcctctggt  gagctgtta  tcaccaagt  acctcccca  180
cctttcaac  gggggacag  attctgttt  attttctac  cccaccccc  ttcttttgt  240
taagaaatg  ttggctgga  catgaaacc  tgtttgagg  caacattca  aggcaactg  300
gcccaggac  ggggtggga  tccaccttc  ctagagaaa  ctgtttaca  aagcaggtt  360
cattttaca  cgggtttgg  ccaggctcc  aagtgatgg  agccaggac  caccacact  420
ttggagccc  ggactctgg  aagcgctga  gggttcttc  tgtgtgtcc  tgcccctct  480
tctctggtg  ctggtgtgt  atgggtggt  ttacaacca  aggtcactc  attaacccc  540
aggaggaat  cgccagc  557



<210> 4946
<211> 188
<212> PRT
<213> Rattus norvegicus
<308> AAD16986
<400> 4946

Met Leu His Asn Lys Leu Arg Gly Gln Val Tyr Pro Pro Ala Ser Asn 
  1               5                  10                  15
Met Glu Tyr Met Thr Trp Asp Glu Glu Leu Glu Arg Ser Ala Ala Ala 
             20                  25                  30
Trp Ala Gln Arg Cys Leu Trp Glu His Gly Pro Ala Ser Leu Leu Val 
         35                  40                  45
Ser Ile Gly Gln Asn Leu Ala Val His Trp Gly Arg Tyr Arg Ser Pro 
     50                  55                  60
Gly Phe His Val Gln Ser Trp Tyr Asp Glu Val Lys Asp Tyr Thr Tyr 
 65                  70                  75                  80
Pro Tyr Pro His Glu Cys Asn Pro Trp Cys Pro Glu Arg Cys Ser Gly 
                 85                  90                  95
Ala Met Cys Thr His Tyr Thr Gln Met Val Trp Ala Thr Thr Asn Lys 
             100                105                110
Ile Gly Cys Ala Val His Thr Cys Arg Ser Met Ser Val Trp Gly Asp 
         115                120                125
Ile Trp Glu Asn Ala Val Tyr Leu Val Cys Asn Tyr Ser Pro Lys Gly 
     130                135                140
Asn Trp Ile Gly Glu Ala Pro Tyr Lys His Gly Arg Pro Cys Ser Glu 
 145                150                155                160
Cys Pro Ser Ser Tyr Gly Gly Gly Cys Arg Asn Asn Leu Cys Tyr Arg 
                 165                170                175
Glu Glu His Tyr His Gln Lys Pro Glu Trp Met Arg 
             180                185



<210> 4947
<211> 4574
<212> DNA
<213> Homo sapiens
<308> NM_031476
<400> 4947

ggcggctgc  cccattgag  tgtctgctc  ctgtgcccg  tgtgcctgc  gtgcccgcg  60
tgtcgccgc  gctaccgcg  ctgctggac  cgggagacg  cagcgagct  gtgattgga  120
ccctgcgga  agctcaagc  cccagctct  cccgaggag  ccaggctgc  ccgtgagtc  180
catagttgc  gcaggagtg  agccatgag  tgcgtcctg  gtggtgtca  ccccttggg  240
ctgctgttc  tggtctgcg  atcccaagg  tacctcctg  ccaacgtca  tctcttaga  300
gagctgctc  gcaaatacc  gcacaacga  tctcactcc  gggtccgca  agccatccc  360
agggaggac  aggaggaga  cctcatgct  cacaacaag  ttcggggcc  ggtgcagcc  420
caggcctcc  acatggagt  catgacctg  gatgacgaa  tggagaagt  tgctgcagc  480
tgggccagt  agtgcatct  ggagcacgg  cccaccagt  tgctggtgt  catcgggca  540
aacctgggc  ctcactggg  caggtatcg  tctccgggg  tccatgtgc  gtcctggta  600
gacgaggtg  aggactaca  ctaccccta  ccgagcgag  gcaacccct  gtgtccaga  660
aggtgctcg  ggcctatgt  cacgcacta  acacagata  tttgggcca  caccaacaa  720
atcggttgt  ctgtgaaca  ctgccggaa  atgactgtc  ggggagaag  ttgggagaa  780
gcggtctac  ttgtctgca  ttattctcc  aaggggaac  ggattggag  agcccccta  840
aagaatggc  ggccctgct  tgagtgccc  cccagctat  gaggcagct  caggaacaa  900
ttgtgttac  gagaagaaa  ctacactcc  aaacctgaa  cggacgaga  gaatgaggt  960
gaaacggct  ccattcctg  agaaaacca  gtttggctc  aaccgaggg  gatgagacc  1020
accaagccc  agaaaacct  tgcggtcaa  tacatgacc  aagtcgtca  atgtgacac  1080
aagatgaag  acaggtgca  agggtccac  tgtaacagg  accagtgcc  agcaggctg  1140
ctgaaccac  aggcgaaga  ctttggaac  ctgttctat  aaagctcgt  tagcatatg  1200
cgcgccgcc  tccactacg  gatcctgga  gacaaggga  gcctggtgg  tatcaccag  1260
aacgggaag  tccccttct  cgtgaagtc  gagagacac  gcgtgcagt  cctcagcaa  1320
tacaaacct  ccagctcat  catggtgtc  aaagtgaaa  tgcaggatt  ggactgcta  1380
acgaccgtt  ctcagctgt  cccgtttga  aagccagca  ctcactgcc  aagaatcca  1440
tgtccggca  actgcaaag  cgaaccttc  tactgggct  cggtgtttg  aaccaacat  1500
tatgcagat  cctcaagca  ctgcaagac  gccgtgcac  cgggagtca  cagcaacga  1560
agtgggggt  acgtggacg  gatgcccgt  gataaaaag  agacctacg  gggctcgct  1620
aggaatgga  ttcagtctg  aagcctggg  actcctcgg  atggaaagg  cttccggat  1680
tttgctgtc  ggcagtgaa  ttccagcac  aggggagaa  gggcgtctt  aggagggct  1740
cggggtttt  cttttattt  tattttgtc  ttgcggggt  tatggagag  caggaaact  1800
cctttgact  atgttcagt  tccatcact  tgtggcctg  gggtgaggt  acatctcat  1860
ccctcactg  agcaacagc  tcccaaggt  ctcagccgg  ctccctggt  cctgatcct  1920
ctggggccc  ggggtctcc  tctggacgt  ctctctcct  tagagatct  agctgtctc  1980
taaagggga  agttgccca  aatgttcct  gctatgtgt  cttctgttg  tggaggaag  2040
tgatttcaa  ctccctgcc  aaagaacaa  ccatttgaa  ctcacaatt  tgaagcatt  2100
acggcgtcg  aagaggcct  ttgagcaag  gccaatgag  ttcaggaat  aagtagaag  2160
tagttattt  aaaataaaa  acacagtcc  tccctacca  tagaggaaa  tggttttaa  2220
gtttgctgg  cagacagac  aatgggcta  agtaagagg  ctgcgggta  gagagaccc  2280
ggctccgcc  tggcacgtg  ccttgctgg  ggcccgcca  aggccccct  caatggccg  2340
attcaggat  gctctatac  cagcagtgc  ggtttatgt  gagttcagc  gtcacttca  2400
agatgtatc  tgtctttgt  aggcccttc  tcttcatgg  ccacctgtt  tctgccgtg  2460
cctttggtc  cattgagga  taaggatcg  gaccctttc  ttaccccct  cccattgtg  2520
ctcccaccc  gcctcggac  ggtttacgt  tcctggttc  cacccagga  ttttctttg  2580
aagcgaacc  gtttgaagc  caagtctta  ctcctggtc  cgtaaggtt  cactgagac  2640
agatgtctg  gaacaacca  agaaggcct  ctctttgct  cttttaaaa  atgacaatt  2700
aatgtgcag  ttccccacg  acccgatga  ctatttttt  agccgtggg  ggaatggag  2760
ctttggtac  ttcctcacc  aggttagca  ctcagtttg  ggttatgaa  ccgtctgtg  2820
cctcatgac  gcgagagat  ggaatacac  agaaggatc  cttttcctg  tttcgtgaa  2880
cgactcttg  caaacgttc  cgaggcgcc  aggagtgta  tacaccctg  ctgccatca  2940
tctataaaa  tgcttcatg  gcccagacc  aaagcccac  gtgaaatga  gtacccttt  3000
gtaaatagc  tttttttgc  gaaggtgaa  attccactc  ctaccaccg  gccagccaa  3060
agatcactt  ggtgaatgc  agtttcaaa  ttgattcaa  atatttctt  ggtgaaaga  3120
ctagcagaa  gtcaaaaac  aagatactg  agactggac  agaaattct  cctgggcac  3180
taggtgatg  cttctttct  tgattgcct  tctaataaa  gcagaatct  aaggtaaat  3240
ggtttaaaa  aaaacaaaa  cccacccct  taaggagtt  gtaaaaagc  gttcaactc  3300
tagcttgac  gagctaaaa  tcacaggac  acgtgcttt  tgcattgta  tctagtcgt  3360
attcatagg  actgactcc  cagccccaa  tgtcggaga  gaagaattc  gtcagcctg  3420
caggtcgtg  gtccagtta  caccaaaca  ctgggaaac  tctgggtgc  gggtgctct  3480
ctgctggac  tttgtggct  tgtctgtgt  tgcaagata  attagatcg  cctgtgggg  3540
ttgcagaat  agtgaaggg  ccaggacga  cccagtggg  tcgcttcca  agcatccca  3600
tcaagggag  cttgaaact  ccagtgtga  ttgacccca  catttaaaa  taaagtccc  3660
gggttcctt  atgcctcct  cactgggcc  tcctagcag  atagaaagt  cttgcccag  3720
gcaggacct  gctgtcttt  ttttttttt  tttcccgag  ccaagtttc  ctctgttgc  3780
caaggtaga  tgcagtggc  tgatctctg  tcattgcaa  tgccgcctc  cgggttcaa  3840
caattctca  gcatcagcc  cccaagtac  tgggactac  ggcgtgagc  accatgccc  3900
gctaatttt  gtattttta  tagagatgg  gtttcatta  gttggccag  ctggtctcg  3960
actccttac  tcaggtgat  cacccacct  ggcctcccg  agtgctggg  ttacaggca  4020
gagccactg  gcccggcca  ggacctggc  gtctttatc  tccccacaa  cattttgaa  4080
ctggaatat  tgtcttcag  aaatggaaa  aagactata  atgataagc  ctgtcccta  4140
caccacctc  cctgtgtgt  gaatagagg  ccctcgtgc  accaacact  accctgtgt  4200
taaaaagat  ttgtaccaa  ccaacggcg  tcctggctc  cctgcccac  ggatgaaca  4260
tttcggctt  cttaggagt  ttgccctac  gtattccaa  gcgtgtgct  gtttctcat  4320
ttgtctgta  gctcactca  cccgcagtt  atgtgtgtg  ttttttcta  gaaaaatga  4380
gtattttgc  acttcctgt  tacaaagtt  tattgtaaa  gttttttgt  ctttgcatg  4440
acaggggcc  cgttgttgc  attgtttca  tagaactgg  ttgatttct  aaatgttcc  4500
gtaacatat  ttttatgaa  aaatctgaa  aatttgtga  ataaaacat  gaaaaccaa  4560
aaaaaaaaa  aaaa  4574



<210> 4948
<211> 497
<212> PRT
<213> Homo sapiens
<308> NP_113664
<400> 4948

Met Ser Cys Val Leu Gly Gly Val Ile Pro Leu Gly Leu Leu Phe Leu 
  1               5                  10                  15
Val Cys Gly Ser Gln Gly Tyr Leu Leu Pro Asn Val Thr Leu Leu Glu 
             20                  25                  30
Glu Leu Leu Ser Lys Tyr Gln His Asn Glu Ser His Ser Arg Val Arg 
         35                  40                  45
Arg Ala Ile Pro Arg Glu Asp Lys Glu Glu Ile Leu Met Leu His Asn 
     50                  55                  60
Lys Leu Arg Gly Gln Val Gln Pro Gln Ala Ser Asn Met Glu Tyr Met 
 65                  70                  75                  80
Thr Trp Asp Asp Glu Leu Glu Lys Ser Ala Ala Ala Trp Ala Ser Gln 
                 85                  90                  95
Cys Ile Trp Glu His Gly Pro Thr Ser Leu Leu Val Ser Ile Gly Gln 
             100                105                110
Asn Leu Gly Ala His Trp Gly Arg Tyr Arg Ser Pro Gly Phe His Val 
         115                120                125
Gln Ser Trp Tyr Asp Glu Val Lys Asp Tyr Thr Tyr Pro Tyr Pro Ser 
     130                135                140
Glu Cys Asn Pro Trp Cys Pro Glu Arg Cys Ser Gly Pro Met Cys Thr 
 145                150                155                160
His Tyr Thr Gln Ile Val Trp Ala Thr Thr Asn Lys Ile Gly Cys Ala 
                 165                170                175
Val Asn Thr Cys Arg Lys Met Thr Val Trp Gly Glu Val Trp Glu Asn 
             180                185                190
Ala Val Tyr Phe Val Cys Asn Tyr Ser Pro Lys Gly Asn Trp Ile Gly 
         195                200                205
Glu Ala Pro Tyr Lys Asn Gly Arg Pro Cys Ser Glu Cys Pro Pro Ser 
     210                215                220
Tyr Gly Gly Ser Cys Arg Asn Asn Leu Cys Tyr Arg Glu Glu Thr Tyr 
 225                230                235                240
Thr Pro Lys Pro Glu Thr Asp Glu Met Asn Glu Val Glu Thr Ala Pro 
                 245                250                255
Ile Pro Glu Glu Asn His Val Trp Leu Gln Pro Arg Val Met Arg Pro 
             260                265                270
Thr Lys Pro Lys Lys Thr Ser Ala Val Asn Tyr Met Thr Gln Val Val 
         275                280                285
Arg Cys Asp Thr Lys Met Lys Asp Arg Cys Lys Gly Ser Thr Cys Asn 
     290                295                300
Arg Tyr Gln Cys Pro Ala Gly Cys Leu Asn His Lys Ala Lys Ile Phe 
 305                310                315                320
Gly Thr Leu Phe Tyr Glu Ser Ser Ser Ser Ile Cys Arg Ala Ala Ile 
                 325                330                335
His Tyr Gly Ile Leu Asp Asp Lys Gly Gly Leu Val Asp Ile Thr Arg 
             340                345                350
Asn Gly Lys Val Pro Phe Phe Val Lys Ser Glu Arg His Gly Val Gln 
         355                360                365
Ser Leu Ser Lys Tyr Lys Pro Ser Ser Ser Phe Met Val Ser Lys Val 
     370                375                380
Lys Val Gln Asp Leu Asp Cys Tyr Thr Thr Val Ala Gln Leu Cys Pro 
 385                390                395                400
Phe Glu Lys Pro Ala Thr His Cys Pro Arg Ile His Cys Pro Ala His 
                 405                410                415
Cys Lys Asp Glu Pro Ser Tyr Trp Ala Pro Val Phe Gly Thr Asn Ile 
             420                425                430
Tyr Ala Asp Thr Ser Ser Ile Cys Lys Thr Ala Val His Ala Gly Val 
         435                440                445
Ile Ser Asn Glu Ser Gly Gly Asp Val Asp Val Met Pro Val Asp Lys 
     450                455                460
Lys Lys Thr Tyr Val Gly Ser Leu Arg Asn Gly Val Gln Ser Glu Ser 
 465                470                475                480
Leu Gly Thr Pro Arg Asp Gly Lys Ala Phe Arg Ile Phe Ala Val Arg 
                 485                490                495
Gln 
             500



<210> 4949
<211> 557
<212> DNA
<213> Rattus norvegicus
<308> AA859581
<400> 4949

ttttttttt  tttttttag  aaccatttg  acttttgct  atgtggatg  gtgtggcgt  60
tgtggagat  atggatctc  tagagttag  cataggtgg  ttatagtta  agtctgtga  120
tcgtgggaa  tgagctcag  tcctctggt  gagctgtta  tcaccaagt  acctcccca  180
cctttcaac  gggggacag  attctgttt  attttctac  cccaccccc  ttcttttgt  240
taagaaatg  ttggctgga  catgaaacc  tgtttgagg  caacattca  aggcaactg  300
gcccaggac  ggggtggga  tccaccttc  ctagagaaa  ctgtttaca  aagcaggtt  360
cattttaca  cgggtttgg  ccaggctcc  aagtgatgg  agccaggac  caccacact  420
ttggagccc  ggactctgg  aagcgctga  gggttcttc  tgtgtgtcc  tgcccctct  480
tctctggtg  ctggtgtgt  atgggtggt  ttacaacca  aggtcactc  attaacccc  540
aggaggaat  cgccagc  557



<210> 4950
<211> 188
<212> PRT
<213> Rattus norvegicus
<308> AAD16986
<400> 4950

Met Leu His Asn Lys Leu Arg Gly Gln Val Tyr Pro Pro Ala Ser Asn 
  1               5                  10                  15
Met Glu Tyr Met Thr Trp Asp Glu Glu Leu Glu Arg Ser Ala Ala Ala 
             20                  25                  30
Trp Ala Gln Arg Cys Leu Trp Glu His Gly Pro Ala Ser Leu Leu Val 
         35                  40                  45
Ser Ile Gly Gln Asn Leu Ala Val His Trp Gly Arg Tyr Arg Ser Pro 
     50                  55                  60
Gly Phe His Val Gln Ser Trp Tyr Asp Glu Val Lys Asp Tyr Thr Tyr 
 65                  70                  75                  80
Pro Tyr Pro His Glu Cys Asn Pro Trp Cys Pro Glu Arg Cys Ser Gly 
                 85                  90                  95
Ala Met Cys Thr His Tyr Thr Gln Met Val Trp Ala Thr Thr Asn Lys 
             100                105                110
Ile Gly Cys Ala Val His Thr Cys Arg Ser Met Ser Val Trp Gly Asp 
         115                120                125
Ile Trp Glu Asn Ala Val Tyr Leu Val Cys Asn Tyr Ser Pro Lys Gly 
     130                135                140
Asn Trp Ile Gly Glu Ala Pro Tyr Lys His Gly Arg Pro Cys Ser Glu 
 145                150                155                160
Cys Pro Ser Ser Tyr Gly Gly Gly Cys Arg Asn Asn Leu Cys Tyr Arg 
                 165                170                175
Glu Glu His Tyr His Gln Lys Pro Glu Trp Met Arg 
             180                185



<210> 4951
<211> 4574
<212> DNA
<213> Homo sapiens
<308> NM_031476
<400> 4951

ggcggctgc  cccattgag  tgtctgctc  ctgtgcccg  tgtgcctgc  gtgcccgcg  60
tgtcgccgc  gctaccgcg  ctgctggac  cgggagacg  cagcgagct  gtgattgga  120
ccctgcgga  agctcaagc  cccagctct  cccgaggag  ccaggctgc  ccgtgagtc  180
catagttgc  gcaggagtg  agccatgag  tgcgtcctg  gtggtgtca  ccccttggg  240
ctgctgttc  tggtctgcg  atcccaagg  tacctcctg  ccaacgtca  tctcttaga  300
gagctgctc  gcaaatacc  gcacaacga  tctcactcc  gggtccgca  agccatccc  360
agggaggac  aggaggaga  cctcatgct  cacaacaag  ttcggggcc  ggtgcagcc  420
caggcctcc  acatggagt  catgacctg  gatgacgaa  tggagaagt  tgctgcagc  480
tgggccagt  agtgcatct  ggagcacgg  cccaccagt  tgctggtgt  catcgggca  540
aacctgggc  ctcactggg  caggtatcg  tctccgggg  tccatgtgc  gtcctggta  600
gacgaggtg  aggactaca  ctaccccta  ccgagcgag  gcaacccct  gtgtccaga  660
aggtgctcg  ggcctatgt  cacgcacta  acacagata  tttgggcca  caccaacaa  720
atcggttgt  ctgtgaaca  ctgccggaa  atgactgtc  ggggagaag  ttgggagaa  780
gcggtctac  ttgtctgca  ttattctcc  aaggggaac  ggattggag  agcccccta  840
aagaatggc  ggccctgct  tgagtgccc  cccagctat  gaggcagct  caggaacaa  900
ttgtgttac  gagaagaaa  ctacactcc  aaacctgaa  cggacgaga  gaatgaggt  960
gaaacggct  ccattcctg  agaaaacca  gtttggctc  aaccgaggg  gatgagacc  1020
accaagccc  agaaaacct  tgcggtcaa  tacatgacc  aagtcgtca  atgtgacac  1080
aagatgaag  acaggtgca  agggtccac  tgtaacagg  accagtgcc  agcaggctg  1140
ctgaaccac  aggcgaaga  ctttggaac  ctgttctat  aaagctcgt  tagcatatg  1200
cgcgccgcc  tccactacg  gatcctgga  gacaaggga  gcctggtgg  tatcaccag  1260
aacgggaag  tccccttct  cgtgaagtc  gagagacac  gcgtgcagt  cctcagcaa  1320
tacaaacct  ccagctcat  catggtgtc  aaagtgaaa  tgcaggatt  ggactgcta  1380
acgaccgtt  ctcagctgt  cccgtttga  aagccagca  ctcactgcc  aagaatcca  1440
tgtccggca  actgcaaag  cgaaccttc  tactgggct  cggtgtttg  aaccaacat  1500
tatgcagat  cctcaagca  ctgcaagac  gccgtgcac  cgggagtca  cagcaacga  1560
agtgggggt  acgtggacg  gatgcccgt  gataaaaag  agacctacg  gggctcgct  1620
aggaatgga  ttcagtctg  aagcctggg  actcctcgg  atggaaagg  cttccggat  1680
tttgctgtc  ggcagtgaa  ttccagcac  aggggagaa  gggcgtctt  aggagggct  1740
cggggtttt  cttttattt  tattttgtc  ttgcggggt  tatggagag  caggaaact  1800
cctttgact  atgttcagt  tccatcact  tgtggcctg  gggtgaggt  acatctcat  1860
ccctcactg  agcaacagc  tcccaaggt  ctcagccgg  ctccctggt  cctgatcct  1920
ctggggccc  ggggtctcc  tctggacgt  ctctctcct  tagagatct  agctgtctc  1980
taaagggga  agttgccca  aatgttcct  gctatgtgt  cttctgttg  tggaggaag  2040
tgatttcaa  ctccctgcc  aaagaacaa  ccatttgaa  ctcacaatt  tgaagcatt  2100
acggcgtcg  aagaggcct  ttgagcaag  gccaatgag  ttcaggaat  aagtagaag  2160
tagttattt  aaaataaaa  acacagtcc  tccctacca  tagaggaaa  tggttttaa  2220
gtttgctgg  cagacagac  aatgggcta  agtaagagg  ctgcgggta  gagagaccc  2280
ggctccgcc  tggcacgtg  ccttgctgg  ggcccgcca  aggccccct  caatggccg  2340
attcaggat  gctctatac  cagcagtgc  ggtttatgt  gagttcagc  gtcacttca  2400
agatgtatc  tgtctttgt  aggcccttc  tcttcatgg  ccacctgtt  tctgccgtg  2460
cctttggtc  cattgagga  taaggatcg  gaccctttc  ttaccccct  cccattgtg  2520
ctcccaccc  gcctcggac  ggtttacgt  tcctggttc  cacccagga  ttttctttg  2580
aagcgaacc  gtttgaagc  caagtctta  ctcctggtc  cgtaaggtt  cactgagac  2640
agatgtctg  gaacaacca  agaaggcct  ctctttgct  cttttaaaa  atgacaatt  2700
aatgtgcag  ttccccacg  acccgatga  ctatttttt  agccgtggg  ggaatggag  2760
ctttggtac  ttcctcacc  aggttagca  ctcagtttg  ggttatgaa  ccgtctgtg  2820
cctcatgac  gcgagagat  ggaatacac  agaaggatc  cttttcctg  tttcgtgaa  2880
cgactcttg  caaacgttc  cgaggcgcc  aggagtgta  tacaccctg  ctgccatca  2940
tctataaaa  tgcttcatg  gcccagacc  aaagcccac  gtgaaatga  gtacccttt  3000
gtaaatagc  tttttttgc  gaaggtgaa  attccactc  ctaccaccg  gccagccaa  3060
agatcactt  ggtgaatgc  agtttcaaa  ttgattcaa  atatttctt  ggtgaaaga  3120
ctagcagaa  gtcaaaaac  aagatactg  agactggac  agaaattct  cctgggcac  3180
taggtgatg  cttctttct  tgattgcct  tctaataaa  gcagaatct  aaggtaaat  3240
ggtttaaaa  aaaacaaaa  cccacccct  taaggagtt  gtaaaaagc  gttcaactc  3300
tagcttgac  gagctaaaa  tcacaggac  acgtgcttt  tgcattgta  tctagtcgt  3360
attcatagg  actgactcc  cagccccaa  tgtcggaga  gaagaattc  gtcagcctg  3420
caggtcgtg  gtccagtta  caccaaaca  ctgggaaac  tctgggtgc  gggtgctct  3480
ctgctggac  tttgtggct  tgtctgtgt  tgcaagata  attagatcg  cctgtgggg  3540
ttgcagaat  agtgaaggg  ccaggacga  cccagtggg  tcgcttcca  agcatccca  3600
tcaagggag  cttgaaact  ccagtgtga  ttgacccca  catttaaaa  taaagtccc  3660
gggttcctt  atgcctcct  cactgggcc  tcctagcag  atagaaagt  cttgcccag  3720
gcaggacct  gctgtcttt  ttttttttt  tttcccgag  ccaagtttc  ctctgttgc  3780
caaggtaga  tgcagtggc  tgatctctg  tcattgcaa  tgccgcctc  cgggttcaa  3840
caattctca  gcatcagcc  cccaagtac  tgggactac  ggcgtgagc  accatgccc  3900
gctaatttt  gtattttta  tagagatgg  gtttcatta  gttggccag  ctggtctcg  3960
actccttac  tcaggtgat  cacccacct  ggcctcccg  agtgctggg  ttacaggca  4020
gagccactg  gcccggcca  ggacctggc  gtctttatc  tccccacaa  cattttgaa  4080
ctggaatat  tgtcttcag  aaatggaaa  aagactata  atgataagc  ctgtcccta  4140
caccacctc  cctgtgtgt  gaatagagg  ccctcgtgc  accaacact  accctgtgt  4200
taaaaagat  ttgtaccaa  ccaacggcg  tcctggctc  cctgcccac  ggatgaaca  4260
tttcggctt  cttaggagt  ttgccctac  gtattccaa  gcgtgtgct  gtttctcat  4320
ttgtctgta  gctcactca  cccgcagtt  atgtgtgtg  ttttttcta  gaaaaatga  4380
gtattttgc  acttcctgt  tacaaagtt  tattgtaaa  gttttttgt  ctttgcatg  4440
acaggggcc  cgttgttgc  attgtttca  tagaactgg  ttgatttct  aaatgttcc  4500
gtaacatat  ttttatgaa  aaatctgaa  aatttgtga  ataaaacat  gaaaaccaa  4560
aaaaaaaaa  aaaa  4574



<210> 4952
<211> 497
<212> PRT
<213> Homo sapiens
<308> NP_113664
<400> 4952

Met Ser Cys Val Leu Gly Gly Val Ile Pro Leu Gly Leu Leu Phe Leu 
  1               5                  10                  15
Val Cys Gly Ser Gln Gly Tyr Leu Leu Pro Asn Val Thr Leu Leu Glu 
             20                  25                  30
Glu Leu Leu Ser Lys Tyr Gln His Asn Glu Ser His Ser Arg Val Arg 
         35                  40                  45
Arg Ala Ile Pro Arg Glu Asp Lys Glu Glu Ile Leu Met Leu His Asn 
     50                  55                  60
Lys Leu Arg Gly Gln Val Gln Pro Gln Ala Ser Asn Met Glu Tyr Met 
 65                  70                  75                  80
Thr Trp Asp Asp Glu Leu Glu Lys Ser Ala Ala Ala Trp Ala Ser Gln 
                 85                  90                  95
Cys Ile Trp Glu His Gly Pro Thr Ser Leu Leu Val Ser Ile Gly Gln 
             100                105                110
Asn Leu Gly Ala His Trp Gly Arg Tyr Arg Ser Pro Gly Phe His Val 
         115                120                125
Gln Ser Trp Tyr Asp Glu Val Lys Asp Tyr Thr Tyr Pro Tyr Pro Ser 
     130                135                140
Glu Cys Asn Pro Trp Cys Pro Glu Arg Cys Ser Gly Pro Met Cys Thr 
 145                150                155                160
His Tyr Thr Gln Ile Val Trp Ala Thr Thr Asn Lys Ile Gly Cys Ala 
                 165                170                175
Val Asn Thr Cys Arg Lys Met Thr Val Trp Gly Glu Val Trp Glu Asn 
             180                185                190
Ala Val Tyr Phe Val Cys Asn Tyr Ser Pro Lys Gly Asn Trp Ile Gly 
         195                200                205
Glu Ala Pro Tyr Lys Asn Gly Arg Pro Cys Ser Glu Cys Pro Pro Ser 
     210                215                220
Tyr Gly Gly Ser Cys Arg Asn Asn Leu Cys Tyr Arg Glu Glu Thr Tyr 
 225                230                235                240
Thr Pro Lys Pro Glu Thr Asp Glu Met Asn Glu Val Glu Thr Ala Pro 
                 245                250                255
Ile Pro Glu Glu Asn His Val Trp Leu Gln Pro Arg Val Met Arg Pro 
             260                265                270
Thr Lys Pro Lys Lys Thr Ser Ala Val Asn Tyr Met Thr Gln Val Val 
         275                280                285
Arg Cys Asp Thr Lys Met Lys Asp Arg Cys Lys Gly Ser Thr Cys Asn 
     290                295                300
Arg Tyr Gln Cys Pro Ala Gly Cys Leu Asn His Lys Ala Lys Ile Phe 
 305                310                315                320
Gly Thr Leu Phe Tyr Glu Ser Ser Ser Ser Ile Cys Arg Ala Ala Ile 
                 325                330                335
His Tyr Gly Ile Leu Asp Asp Lys Gly Gly Leu Val Asp Ile Thr Arg 
             340                345                350
Asn Gly Lys Val Pro Phe Phe Val Lys Ser Glu Arg His Gly Val Gln 
         355                360                365
Ser Leu Ser Lys Tyr Lys Pro Ser Ser Ser Phe Met Val Ser Lys Val 
     370                375                380
Lys Val Gln Asp Leu Asp Cys Tyr Thr Thr Val Ala Gln Leu Cys Pro 
 385                390                395                400
Phe Glu Lys Pro Ala Thr His Cys Pro Arg Ile His Cys Pro Ala His 
                 405                410                415
Cys Lys Asp Glu Pro Ser Tyr Trp Ala Pro Val Phe Gly Thr Asn Ile 
             420                425                430
Tyr Ala Asp Thr Ser Ser Ile Cys Lys Thr Ala Val His Ala Gly Val 
         435                440                445
Ile Ser Asn Glu Ser Gly Gly Asp Val Asp Val Met Pro Val Asp Lys 
     450                455                460
Lys Lys Thr Tyr Val Gly Ser Leu Arg Asn Gly Val Gln Ser Glu Ser 
 465                470                475                480
Leu Gly Thr Pro Arg Asp Gly Lys Ala Phe Arg Ile Phe Ala Val Arg 
                 485                490                495
Gln 
             500



<210> 4953
<211> 478
<212> DNA
<213> Rattus norvegicus
<308> AA859597
<400> 4953

ttttttttt  ttttgcttt  tagatacaa  gtctcatat  actcagact  gcctggaac  60
tattacgta  ctggggcta  atttgtatt  aggacctcc  gtctgcacc  cctaatgct  120
ggatttcag  cagggtttt  tctctgaag  cctggcatt  ccggaactt  gtatgtaga  180
cagccttga  ctcacagag  tctgcctta  tgctggatc  aaggcttac  ccacaagtt  240
ttaaattta  gtttaaata  aaattaaat  ggaagtctg  agattacag  aaggtagtc  300
gggaaattt  tcttgcatc  tttgttttg  tttggtttt  ggaaacagt  ttgggactg  360
agcgatgac  cagcagata  gagccatct  ccagggctg  tcttccaga  gacccaggt  420
aattcccag  tcacacgtg  tgacttatg  ctggcgagc  ctaatttct  ggctctcc  478



<210> 4954
<211> 478
<212> DNA
<213> Rattus norvegicus
<308> AA859597
<400> 4954

ttttttttt  ttttgcttt  tagatacaa  gtctcatat  actcagact  gcctggaac  60
tattacgta  ctggggcta  atttgtatt  aggacctcc  gtctgcacc  cctaatgct  120
ggatttcag  cagggtttt  tctctgaag  cctggcatt  ccggaactt  gtatgtaga  180
cagccttga  ctcacagag  tctgcctta  tgctggatc  aaggcttac  ccacaagtt  240
ttaaattta  gtttaaata  aaattaaat  ggaagtctg  agattacag  aaggtagtc  300
gggaaattt  tcttgcatc  tttgttttg  tttggtttt  ggaaacagt  ttgggactg  360
agcgatgac  cagcagata  gagccatct  ccagggctg  tcttccaga  gacccaggt  420
aattcccag  tcacacgtg  tgacttatg  ctggcgagc  ctaatttct  ggctctcc  478



<210> 4955
<211> 437
<212> DNA
<213> Rattus norvegicus
<308> AA859627
<400> 4955

ttttttttt  tttctttgg  ttttaattc  ttttttttt  attattatt  ttggtttgt  60
tgagagagg  tgagaaggt  tggtttaca  tgagtatat  ttgtcaagt  gccaaagtc  120
acatagctc  cctgttttc  gtatacgtt  acagcctca  aaaaaaaaa  aaaaataat  180
gaaatggct  taaaaaccg  acagaacac  tccatcctg  gataagtac  tcgaatgga  240
tcagcttta  ccctctgtg  ctcatcctc  cattctcag  atatttaac  gaccaacaa  300
accaagtac  agtagtgag  ggctgaccc  cgtggcttt  cagtgctct  cgtccagaa  360
catggcaca  gatgcttgt  catgtggaa  cttagcgac  gtcaacata  attctcagg  420
atttatccc  cgtgccg  437



<210> 4956
<211> 4087
<212> DNA
<213> Homo sapiens
<308> AB046797
<400> 4956

ggaatagtg  tgatgtctg  ccatgggaa  atggaaatc  tggcagtga  ttacccaac  60
taaccaatg  tctgcctca  ggtgcaaat  ccaaccaag  ttcatcgaa  aggccacat  120
ggacagtgt  cacccgagc  atcgaggca  gcgatctcc  ctggcagga  agccacttg  180
agcacatta  cagcagtga  ctatacacc  actactgtt  ccatgacga  actgaaaac  240
ccctcttcg  ctcccgcgg  tggcccctc  ggcatgaac  tgttcctac  gcctgtgca  300
gagtggacg  attacgttc  catgggtac  ccagagaag  actgagact  gcaatagct  360
ttgttaata  attaagacg  cagcagcag  aacagttgg  aatgttccg  acccaaaaa  420
aagagctac  ccataaaaa  ataacctcg  taaccaatc  ggagggctg  gttggacat  480
ccctggacc  tgtgggcac  ctcttcagt  gccttatgg  agcctgccg  attgatgat  540
agaacctct  tgggttctc  gattttaca  agaatatgg  acagtgcaa  tctctggaa  600
accagcatc  acctgcaca  aaattctta  aagaagggg  atcctattt  acgctggct  660
tggaagtag  cctgatagg  ctaggacag  agcgtatca  gcctgatgg  ctgtacaca  720
aagagaaag  ttgccggaa  gaggagcag  tcatttcta  gcttcagga  attgaattg  780
atgacacac  ggtgaaaat  tttcgcaag  aagcagtct  cctattaga  gccggacca  840
atagtggtt  aggtgaaat  atccatcgg  agagcgttc  aatgcacac  tttgccaag  900
atctcttca  ctctctcct  cctcacgat  ctgaattgg  atacaaaat  gcactgaga  960
caatgcggt  actagtatt  gaatctact  ctccatcag  agacctcac  cgcccacac  1020
acattgcat  agttgttcc  aaccgctac  ctcgctggt  cactctaag  cacattgag  1080
cccagcagt  tgagctggc  tccaccatg  taactgcag  caaaggcga  gttcggagg  1140
tggaaacag  attagaatc  atccagaaa  acattcact  ctcatcaca  atcttcaag  1200
ttgcccaag  tgcatttaa  atagcaact  tcatggaca  tttgccaga  atcactctt  1260
tgaaagtgt  tctggagct  ggcctgcag  ttatgcgaa  gacactgtc  accttaaat  1320
ggcgacggc  ggagatggt  aggtggctg  taacgtgtg  tactgaagt  ggggtttat  1380
ccctggaca  catcatgca  acctggttt  cactcttta  tcccaccga  gccacaagt  1440
tagttgcaa  taccgtgat  tccaacagc  ccatcgtcc  cctccacct  gactgccac  1500
agcaggaaa  gctggccag  agcgcccgg  cacttgcac  gcagtgtgc  atgaaggat  1560
cacagaact  tgccctctc  gcgctaacc  tttgtgaaa  ggatcacat  gcttttgag  1620
cggcgtacc  aattgttct  gacgctgct  cgactggca  gagctatac  cagctcttt  1680
caatagcac  gtacatgga  caccgcggg  accccatga  ggcctacaa  ctggccacc  1740
tggccatga  ccatctcaa  ctgagctac  atcaggaca  acaccctgc  attaatgat  1800
ttttgtggg  ctgtgcgct  agccactcc  ttggtaaaa  tgagcttgc  gctataata  1860
ctctggtgg  caagagtgt  aagtgtgca  cggtactgt  agacatttt  cgcagatgc  1920
ctctgacca  tcctggcat  gtgggactt  atgggagga  gaactctgg  aagctcatg  1980
cactggaca  agccccctt  aggcaactc  tggatgcca  gatcggggc  tacatcaac  2040
caacgcact  acggctcac  cacatcagt  ctcggcact  tagtgagtt  atagagttc  2100
tcagcaaag  ccgagagac  ttcttaatg  cgcatgatg  acacattca  tttacacag  2160
ttattgaca  cctgaaaca  atctacaaa  gcaaaaaga  actgatgat  ttggttcgg  2220
agaggtttg  ttgatagat  ttgtatgaa  ggggtgggg  gtggggatg  gagggatgg  2280
ttgttttta  ttgagcctg  ctttgtacc  tttttaact  aaagaacag  gccacaccg  2340
tattatatg  gtatagtta  attgcgttt  cagactaaa  tgtcatgtt  tgaaagttt  2400
tgtgttttt  attttttcc  tatttcttt  tttccttta  tttattatt  tttttaatt  2460
tttttttct  gttttgtat  agagagagg  taaaaaggt  tggtttaca  tgagtatat  2520
ttgtcaagt  gcaaaagtc  acatagctc  cctgttttc  gtatacgtt  acagcctca  2580
aaaaaataa  tgaaatggc  ttaaaaacc  aacaaaaca  ctccatcct  tgataagta  2640
ctcgaatgg  ttcagcttt  ctcctttgt  actcatctt  acattttca  catatttaa  2700
caaaccaac  aaatgaaat  ctaatagta  aaaggctga  ccatgtggc  ttgcagtgc  2760
gttcgtcca  aagcatggc  cacgatgct  gtgcatgtg  aaacttagc  actgtcaac  2820
tacattctc  gggatttat  caaaaaaat  aaaaaaaga  tgagagcat  tattgtact  2880
tatatatat  atagtatat  tctgaatat  gaaaatata  cattaacta  tttataaaa  2940
atattctat  taatgcaaa  tacttgaag  tgcagtagc  tggttttaa  caaaaacaa  3000
aaaaaaact  agagaaaac  tatcagaag  actaaaagt  cgccttgct  cagggttgg  3060
tcaggtggt  aacttcatg  tgggcatct  tgcagagcc  ccttttgga  tgcatggtt  3120
gactgagat  tattgggag  aattatata  gtatatata  ttatacaac  tatgtatac  3180
tatatatat  tatacacac  gacacacac  cacaccacc  acaaccacc  ctacaccac  3240
catgcttat  acaggcact  gaataaaga  ggacaacaa  atacacagc  agagcagca  3300
gccttagca  taagaatat  caatatgcc  gaattgggg  tcgtgcctc  tagcctagg  3360
aacttaaaa  aaatatcct  ttgacacaa  acacaaaat  ttttccaaa  caattgaca  3420
aatgataca  tacgccttt  cagtgagct  ataataagc  aacctttgt  cacaaataa  3480
attatatat  ttatatatc  attctgcat  ggtattttg  ctttgtgca  gacagaaag  3540
tgtgtaggt  tgactgttc  acttttcag  tttcttttt  tttaatata  tttattttc  3600
ctagaaatt  ctcaaacaa  agcagcctt  tatcttgcc  tgtcttaat  ctttaaaat  3660
accaaactg  agatctaac  accaaactg  tcattatat  attaaatac  aactttggt  3720
acagtatag  gtctttact  tagctgatg  ttctgtaac  ttgtgcttt  taaagcaat  3780
tttatgttt  ggtgcaaaa  ttgtccagt  tctcttgtt  ccttcacta  agaacatgc  3840
tagaggtat  tttgtaggt  tttttgttt  gaagaacta  ttcatgcgc  ccattttat  3900
tattataat  ggtaaaaag  aaaaaaaag  ttgtaattc  tcacccatg  aaacatgct  3960
atgaagttg  aagtaatta  gatttgata  actgatatc  atttattta  gtaactaaa  4020
cactgtttt  taaacttgt  aatgatcaa  aatttttgt  ttgattaaa  ttagttttt  4080
gaaagtt  4087



<210> 4957
<211> 455
<212> DNA
<213> Rattus norvegicus
<308> AA859632
<400> 4957

ttttttttt  ctttttttt  tagaaaaca  ggtagctct  attttatgg  caaactgta  60
ataaacctt  atccaaagc  cccatcatt  ggagccgag  attcttggt  tgtactcat  120
tatctcgca  agagtgcat  aggaatcag  tgtccatgt  atgcatggg  cacttttgt  180
accttgaat  gcaaactat  atgctggta  aatactctc  ttattaatt  ggttggatt  240
gaatattca  catttctta  taactctgt  aattgcaat  ctgcaagtg  acggtcaga  300
ctcaagttc  cagcatccc  ttgcactga  cacattgct  ctgtacgta  tctcaggcc  360
cttggctag  cagggtgag  agacacggg  ctgctacac  ttcctgtcc  cgtgcagtc  420
taaacctca  gttgaaaca  agtctaagc  gggtc  455



<210> 4958
<211> 1131
<212> PRT
<213> Rattus norvegicus
<308> NP_035388
<400> 4958

Met Asp Ile Arg Lys Phe Phe Gly Val Ile Ser Ser Gly Lys Lys Pro 
  1               5                  10                  15
Val Asn Glu Thr Val Lys Asn Glu Lys Thr Lys Ala Ser Glu Gly Thr 
             20                  25                  30
Val Lys Gly Lys Lys Gly Val Lys Glu Ala Lys Val Asn Asn Ser Gly 
         35                  40                  45
Lys Glu Asp Ala Ser Lys Pro Lys Gln His Ser Lys Lys Lys Arg Ile 
     50                  55                  60
Ile Tyr Asp Ser Asp Ser Glu Ser Glu Glu Thr Val Gln Val Lys Asn 
 65                  70                  75                  80
Ala Lys Lys Lys Ser Glu Lys Leu Ser Leu Ser Tyr Lys Pro Gly Lys 
                 85                  90                  95
Val Ser Gln Lys Asp Pro Val Thr Tyr Val Ser Glu Thr Asp Glu Asp 
             100                105                110
Asp Asp Phe Val Cys Lys Lys Ala Ala Ser Lys Ser Lys Glu Asn Gly 
         115                120                125
Val Ser Thr Asn Ser Tyr Leu Gly Thr Ser Asn Val Lys Lys Asn Glu 
     130                135                140
Glu Asn Val Lys Thr Lys Asn Lys Pro Leu Ser Pro Ile Lys Leu Thr 
 145                150                155                160
Pro Thr Ser Val Leu Asp Tyr Phe Gly Thr Glu Ser Val Gln Arg Ser 
                 165                170                175
Gly Lys Lys Met Val Thr Ser Lys Arg Lys Glu Ser Ser Gln Asn Thr 
             180                185                190
Glu Asp Ser Arg Leu Asn Asp Glu Ala Ile Ala Lys Gln Leu Gln Leu 
         195                200                205
Asp Glu Asp Ala Glu Leu Glu Arg Gln Leu His Glu Asp Glu Glu Phe 
     210                215                220
Ala Arg Thr Leu Ala Leu Leu Asp Glu Glu Pro Lys Ile Lys Lys Ala 
 225                230                235                240
Arg Lys Asp Ser Glu Glu Gly Glu Glu Ser Phe Ser Ser Val Gln Asp 
                 245                250                255
Asp Leu Ser Lys Ala Glu Lys Gln Lys Ser Pro Asn Lys Ala Glu Leu 
             260                265                270
Phe Ser Thr Ala Arg Lys Thr Tyr Ser Pro Ala Lys His Gly Lys Gly 
         275                280                285
Arg Ala Ser Glu Asp Ala Lys Gln Pro Cys Lys Ser Ala His Arg Lys 
     290                295                300
Glu Ala Cys Ser Ser Pro Lys Ala Ser Ala Lys Leu Ala Leu Met Lys 
 305                310                315                320
Ala Lys Glu Glu Ser Ser Tyr Asn Glu Thr Glu Leu Leu Ala Ala Arg 
                 325                330                335
Arg Lys Glu Ser Ala Thr Glu Pro Lys Gly Glu Lys Thr Thr Pro Lys 
             340                345                350
Lys Thr Lys Val Ser Pro Thr Lys Arg Glu Ser Val Ser Pro Glu Asp 
         355                360                365
Ser Glu Lys Lys Arg Thr Asn Tyr Gln Ala Tyr Arg Ser Tyr Leu Asn 
     370                375                380
Arg Glu Gly Pro Lys Ala Leu Gly Ser Lys Glu Ile Pro Lys Gly Ala 
 385                390                395                400
Glu Asn Cys Leu Glu Gly Leu Thr Phe Val Ile Thr Gly Val Leu Glu 
                 405                410                415
Ser Ile Glu Arg Asp Glu Ala Lys Ser Leu Ile Glu Arg Tyr Gly Gly 
             420                425                430
Lys Val Thr Gly Asn Val Ser Lys Lys Thr Asn Tyr Leu Val Met Gly 
         435                440                445
Arg Asp Ser Gly Gln Ser Lys Ser Asp Lys Ala Ala Ala Leu Gly Thr 
     450                455                460
Lys Ile Leu Asp Glu Asp Gly Leu Leu Asp Leu Ile Arg Thr Met Pro 
 465                470                475                480
Gly Lys Arg Ser Lys Tyr Glu Met Ala Ala Glu Ala Glu Met Lys Lys 
                 485                490                495
Glu Lys Ser Lys Leu Glu Arg Thr Pro Gln Lys Asn Asp Gln Gly Lys 
             500                505                510
Arg Lys Ile Ser Pro Ala Lys Lys Glu Ser Glu Ser Lys Lys Cys Lys 
         515                520                525
Leu Thr Leu Leu Lys Asn Ser Pro Met Lys Ala Val Lys Lys Glu Ala 
     530                535                540
Ser Thr Cys Pro Arg Gly Leu Asp Val Lys Glu Thr His Gly Asn Arg 
 545                550                555                560
Ser Ser Asn Lys Glu Glu Cys Leu Leu Trp Val Asp Lys Tyr Lys Pro 
                 565                570                575
Ala Ser Leu Lys Asn Ile Ile Gly Gln Gln Gly Asp Gln Ser Cys Ala 
             580                585                590
Asn Lys Leu Leu Arg Trp Leu Arg Asn Trp His Lys Ser Ser Pro Glu 
         595                600                605
Glu Lys Lys His Ala Ala Lys Phe Gly Lys Leu Ala Ser Lys Asp Asp 
     610                615                620
Gly Ser Ser Phe Lys Ala Ala Leu Leu Ser Gly Pro Pro Gly Val Gly 
 625                630                635                640
Lys Thr Thr Thr Ala Ser Leu Val Cys Gln Glu Leu Gly Tyr Ser Tyr 
                 645                650                655
Val Glu Leu Asn Ala Ser Asp Thr Arg Ser Lys Asn Ser Leu Lys Ala 
             660                665                670
Val Val Ala Glu Ser Leu Asn Asn Thr Ser Ile Lys Gly Phe Tyr Thr 
         675                680                685
Ser Gly Ala Ala Pro Ser Val Ser Ala Arg His Ala Leu Ile Met Asp 
     690                695                700
Glu Val Asp Gly Met Ala Gly Asn Glu Asp Arg Gly Gly Ile Gln Glu 
 705                710                715                720
Leu Ile Gly Leu Ile Lys His Thr Lys Ile Pro Ile Ile Cys Met Cys 
                 725                730                735
Asn Asp Arg Asn His Pro Lys Ile Arg Ser Leu Val His Tyr Cys Phe 
             740                745                750
Asp Leu Arg Phe Gln Arg Pro Arg Val Glu Gln Ile Lys Ser Ala Met 
         755                760                765
Leu Ser Ile Ala Phe Lys Glu Gly Leu Lys Ile Pro Pro Pro Ala Met 
     770                775                780
Asn Glu Ile Ile Leu Gly Ala Asn Gln Asp Val Arg Gln Val Leu His 
 785                790                795                800
Asn Leu Ser Met Trp Cys Ala Gln Ser Lys Ala Leu Thr Tyr Asp Gln 
                 805                810                815
Ala Lys Ala Asp Ser Gln Arg Ala Lys Lys Asp Ile Arg Leu Gly Pro 
             820                825                830
Phe Asp Val Thr Arg Lys Val Phe Ala Ala Gly Glu Glu Thr Ala His 
         835                840                845
Met Ser Leu Met Asp Lys Ser Asp Leu Phe Phe His Asp Tyr Ser Ile 
     850                855                860
Ala Pro Leu Phe Val Gln Glu Asn Tyr Leu His Val Lys Pro Val Ala 
 865                870                875                880
Ala Gly Gly Asp Met Lys Lys His Leu Met Leu Leu Ser Arg Ala Ala 
                 885                890                895
Asp Ser Ile Cys Asp Gly Asp Leu Val Asp Asn Gln Ile Arg Ser Lys 
             900                905                910
Gln Asn Trp Ser Leu Leu Pro Thr Gln Ala Ile Tyr Ala Ser Val Leu 
         915                920                925
Pro Gly Glu Leu Met Arg Gly Tyr Met Thr Gln Phe Pro Ser Phe Pro 
     930                935                940
Ser Trp Leu Gly Lys His Ser Ser Thr Gly Lys His Asp Arg Ile Val 
 945                950                955                960
Gln Asp Leu Ser Leu His Met Ser Leu Arg Thr Tyr Ser Ser Lys Arg 
                 965                970                975
Thr Val Asn Met Asp Tyr Leu Ser His Ile Arg Asp Ala Leu Val Arg 
             980                985                990
Pro Leu Thr Ser Gln Gly Val Glu Gly Ala Gln His Val Ile Lys Leu 
         995                1000                1005
Met Asp Thr Tyr Tyr Leu Met Lys Glu Asp Phe Glu Asn Ile Met Glu 
     1010                1015                1020
Val Ser Ser Trp Gly Gly Lys Pro Ser Ala Phe Ser Lys Leu Asp Pro 
 1025                1030                1035                1040
Lys Val Lys Ala Ala Phe Thr Arg Ala Tyr Asn Lys Glu Ala His Leu 
                 1045                1050                1055
Thr Pro Tyr Ser Leu Gln Val Val Lys Thr Ser Arg Leu Ser Thr Gly 
             1060                1065                1070
Pro Ala Leu Asp Ser Glu Tyr Ser Glu Glu Phe Gln Glu Asp Asp Thr 
         1075                1080                1085
Gln Ser Glu Lys Glu Gln Asp Ala Val Glu Thr Asp Ala Met Ile Lys 
     1090                1095                1100
Lys Lys Thr Arg Ser Ser Lys Pro Ser Lys Ser Glu Arg Glu Lys Glu 
 1105                1110                1115                1120
Ser Lys Lys Gly Lys Gly Lys Asn Trp Lys Lys 
                 1125                1130



<210> 4959
<211> 4952
<212> DNA
<213> Homo sapiens
<308> L23320
<400> 4959

tcagtctgg  actcttttt  gaatgttgt  aaaactagt  aattggaag  taacggtac  60
atttatact  aaagagtac  agactgtct  cgccttctt  cacttcgcg  gagaagttg  120
tggcgcgaa  ggatcctga  cctcgataa  agattcctc  accggccca  ccgccagcc  180
gccagcgcc  tcatcctgg  gctgcgatg  acattcgga  attctttgg  gtaatacca  240
gtggaaaga  acttgtaag  gaaacagta  agaagaatg  gaaaacaaa  tctgatgaa  300
aaactttaa  agcaaagaa  ggaataaag  aaatcaagg  aaatagctc  cgtaaagag  360
atgacttca  acaaaagca  ccaagcaag  aaaagagga  catctatga  tcagattca  420
agtcagagg  gacgttgca  gtaaaaaat  ccaaaaagc  accagaaaa  ctgccagta  480
cttctaaac  tggtaaaat  tcacggcag  atcctgtta  atacatttc  gaaacagat  540
aagaagatg  ctttatgtg  aagaaggcg  cctctaaat  aaaagagaa  ggaagatct  600
caaatagtc  tcttggaac  tcaaacatg  aaaagaatg  agaaaacac  aagaccaag  660
ataagcctt  atcaccaat  aaacttaca  ccacatcag  acttgatta  tttggaact  720
gaagtgtcc  aagatctaa  aagaagatg  tggcaagca  aagaaaaga  ctttcacaa  780
atacagatg  gtctggatt  aatgatgaa  ccatcgcca  gcaattaca  cttgatgaa  840
atgcggagc  ggagaggca  ttgcatgaa  atgaagagt  tgccagaac  ttagccatg  900
tggatgaag  acccaagac  aaaaaggct  gaaaggaca  agaagcggg  gaaacgttt  960
catctgtcc  agccaattt  agtaaagca  aaaaacata  atatcctca  aaagtaaaa  1020
cagcacaag  ttcagatga  agaaagagc  acagtccta  gaagcaaag  aaatatgaa  1080
gttcaaaag  atctcagca  cattccaag  catcagctg  caaaatagg  gaagtctct  1140
ctcccaagg  cagttctaa  ctggcaatt  tgaaaagaa  aaaagagag  tcttataaa  1200
aaatagagc  tgtggcctc  aaaagaaaa  aaaatgcca  taaattgaa  ggagagaca  1260
aaactccta  gaaaaccaa  agttctcca  ctaaaaaag  gtctgtaag  cctgaagat  1320
ctgaaaaga  acgcactaa  tatcaagct  atcgaagct  cttaaatcg  gaaggtccc  1380
aggctctgg  ctccaaaga  ataccaaag  gagctgaaa  ttgcttgga  ggccttata  1440
ttgtaatca  aggcgtgct  gagtctatt  aacgagatg  ggccaagtc  ctaattgaa  1500
gttatgggg  aaaagtaac  ggaaatgtc  gcaagaaaa  aaattatct  gtcatgggt  1560
gtgatagtg  acagtccaa  agtgataag  ccgcagcct  ggggacaaa  attattgat  1620
aagatggcc  gttgaatct  attcggact  tgccaggca  gaaatccaa  tatgaaata  1680
cagttgaaa  tgagatgaa  aaagagtcc  aactggaga  aacacccca  aaaaatgtc  1740
aaggaaaaa  aaaaattag  ccatctaaa  aggaatcag  atctaaaaa  agcaggccg  1800
cttccaaaa  ggacagttt  gcaaagaca  taaaaaagg  aacagatgt  ttttggaaa  1860
gcctggatt  caaggagca  gtggctgag  agacaagtg  tgacagcaa  gctaggaat  1920
tggctgatg  cagcagtga  aacaaagtg  aaaatttgc  ctgggtgga  aaatataag  1980
caacctcgc  caagaccat  attggacag  aaggtgacc  gagctgtgc  aacaaactc  2040
tacgctggc  ccgaaactg  caaaagagt  cttccgaag  taaaaaaca  gcagcaaag  2100
ttggtaaat  ttccggcaa  gatgatggc  ctagtttta  agcagcgtt  ctgtcaggc  2160
ctcctggtg  tggcaaaac  accacagct  ccctggtgt  tcaggagtt  ggatacagc  2220
acgtggaac  gaatgcaag  gacacccgg  gtaagagca  tttgaaagc  attgttgct  2280
agtcactga  caataccag  atcaaaggc  tttattcaa  tggagcagc  tcttcagta  2340
gcacgaaac  tgctctcat  atggatgaa  tagatggca  ggcaggcaa  gaggatagg  2400
gaggaattc  ggaattaat  ggcctgata  aacatacta  aattcccat  atttgtatg  2460
gcaatgata  aaatcatcc  aagattcgc  ctctggttc  ttattgttt  gatcttcgt  2520
ttcaaagac  tcgggttga  cagattaag  gtgctatga  gtctattgc  tttaaagaa  2580
gtttaaaga  tccccctcc  gctatgaat  aaataattt  gggagccaa  caagatatc  2640
gacaggttt  acataatct  agtatgtgg  gtgcacgaa  taaagcatt  acctatgac  2700
aggccaaag  tgattctca  agagccaaa  aggatatca  aatgggccc  tttgatgtt  2760
cccggaaag  gtttgcagc  ggagaggag  ctgctcaca  gtcacttgt  gacaagtca  2820
atctctttt  tcatgatta  tcaatagca  ccctcttcg  ccaggaaaa  tacatacac  2880
tgaagcctg  agcagcagg  ggtgacatg  aaaagcacc  gatgctttt  agcagagca  2940
cagacagca  atgcgatgg  gacctagtg  acagccaga  ccggagtaa  caaaactgg  3000
gtcttctgc  tgcgcaggc  atttatgcc  gtgttcttc  tggagagtt  atgaggggg  3060
acatgaccc  gtttcccac  ttcccaagc  ggctgggga  gcactcgtc  acaggcaaa  3120
atgatcgta  tgttcagga  ctggccttg  atatgagtc  cagaactta  tccagcaaa  3180
ggactgtaa  catggatta  ctgtcgctt  taagggatg  acttgtaca  cccttgacc  3240
cacaaggag  agacggagt  caggatgtt  ttgcactta  ggacacata  tatttgatg  3300
aagaagact  tgagaatat  atggaaatc  gcagctggg  tggcaaacc  agtcccttt  3360
caaagctgg  tcccaaggt  aaagcagcc  tcacaagag  ttacaataa  gaagcccac  3420
ttactccat  ctcacttca  gctataaag  catctagac  cagcacaag  ccatccctg  3480
attcggaat  caatgaaga  ttaaatgaa  atgactctc  atctgatga  aaagaccaa  3540
atgctatag  aactgatgc  atgatcaag  aaaagacaa  atcttcaaa  ccttcaaaa  3600
cagaaaaag  taaggagcc  agaaaagga  aaggaaaaa  ttcgaagaa  tgaaaccat  3660
tttcactag  gacagccac  ttttactct  cctcctgac  agtccagct  gtctagaga  3720
agccttgtt  tttcccaga  caaccatgt  ttagcataa  gggatgacc  ggtgtccca  3780
tataaataa  gggtggtat  gctagaagg  tatgagcag  aggcttatg  acacctctt  3840
tagaggttg  taggactgc  tgggtcctc  actgtcctc  gtcaatcta  ttagacgtg  3900
ttctgaatg  ctgtagaat  ggaactaga  actacacct  ggctttgga  tcagatttt  3960
gttaacaat  atgagcctg  agcagtagt  ctaaggcgt  ttttgtagg  ttaagaatt  4020
atcctaatg  cctttatag  accaatgct  atttttttt  aaggcagtt  ctattatgt  4080
gtgaaattt  gtaaataaa  gattataca  aacagtcac  acctagaac  gggtattct  4140
tgtacattg  cagatatct  tcaaagtat  aattaggaa  aaaaatgtt  cacatgata  4200
gtgtacaaa  tctttttaa  attgtcatc  tgtacagca  aatattatg  tggtatatt  4260
cttccttat  aatttgcaa  tgattggat  aaaaaagct  actgtattc  ttactaacc  4320
gttgtgtga  acataacat  ggcagtcga  gagtcagaa  tcggattcc  agcctcact  4380
cctctgtgt  tgttgacca  gtctctgct  tgaatagga  ttcatgcag  ggtctgtta  4440
ggggctttg  agcgtgggg  gctgcagaa  attctcaga  attcttatc  ttctggagt  4500
tcaacccat  aggttcaga  cagtaggaa  caggctggg  caggctctt  atttcacta  4560
ggtggggga  aaaatgaac  ctggctttt  ttcactttg  ccctgagag  tctagtcct  4620
tcctgtgat  gcttccaca  accctgttg  aagtttggg  tattcctat  actgtatgt  4680
ttgagtggc  gtgacgtat  gacctagcc  ggaatttag  tgtctagct  ttttttaat  4740
ttgttggta  atgctcaga  gtctgtgct  cctctgtga  gtatatact  aaatgaatg  4800
aaaataagg  tcgtattcc  tgctttaag  aactggtag  cttgtttgg  tgatgagac  4860
aagttcttg  gacatttaa  ctgtattta  cagtgtgaa  aatgtcatt  atggagatt  4920
attcattat  gaaataaaa  attgcctaa  ca  4952



<210> 4960
<211> 1147
<212> PRT
<213> Homo sapiens
<308> AAA16121
<400> 4960

Met Asp Ile Arg Lys Phe Phe Gly Val Ile Pro Ser Gly Lys Lys Leu 
  1               5                  10                  15
Val Ser Glu Thr Val Lys Lys Asn Glu Lys Thr Lys Ser Asp Glu Glu 
             20                  25                  30
Thr Leu Lys Ala Lys Lys Gly Ile Lys Glu Ile Lys Val Asn Ser Ser 
         35                  40                  45
Arg Lys Glu Asp Asp Phe Lys Gln Lys Gln Pro Ser Lys Lys Lys Arg 
     50                  55                  60
Ile Ile Tyr Asp Ser Asp Ser Glu Ser Glu Glu Thr Leu Gln Val Lys 
 65                  70                  75                  80
Asn Ala Lys Lys Pro Pro Glu Lys Leu Pro Val Ser Ser Lys Pro Gly 
                 85                  90                  95
Lys Ile Ser Arg Gln Asp Pro Val Thr Tyr Ile Ser Glu Thr Asp Glu 
             100                105                110
Glu Asp Asp Phe Met Cys Lys Lys Ala Ala Ser Lys Ser Lys Glu Asn 
         115                120                125
Gly Arg Ser Thr Asn Ser His Leu Gly Thr Ser Asn Met Lys Lys Asn 
     130                135                140
Glu Glu Asn Thr Lys Thr Lys Asn Lys Pro Leu Ser Pro Ile Lys Leu 
 145                150                155                160
Thr Pro Thr Ser Val Leu Asp Tyr Phe Gly Thr Gly Ser Val Gln Arg 
                 165                170                175
Ser Asn Lys Lys Met Val Ala Ser Lys Arg Lys Glu Leu Ser Gln Asn 
             180                185                190
Thr Asp Glu Ser Gly Leu Asn Asp Glu Ala Ile Ala Lys Gln Leu Gln 
         195                200                205
Leu Asp Glu Asp Ala Glu Leu Glu Arg Gln Leu His Glu Asp Glu Glu 
     210                215                220
Phe Ala Arg Thr Leu Ala Met Leu Asp Glu Glu Pro Lys Thr Lys Lys 
 225                230                235                240
Ala Arg Lys Asp Thr Glu Ala Gly Glu Thr Phe Ser Ser Val Gln Ala 
                 245                250                255
Asn Leu Ser Lys Ala Glu Lys His Lys Tyr Pro His Lys Val Lys Thr 
             260                265                270
Ala Gln Val Ser Asp Glu Arg Lys Ser Tyr Ser Pro Arg Lys Gln Ser 
         275                280                285
Lys Tyr Glu Ser Ser Lys Glu Ser Gln Gln His Ser Lys Ser Ser Ala 
     290                295                300
Asp Lys Ile Gly Glu Val Ser Ser Pro Lys Ala Ser Ser Lys Leu Ala 
 305                310                315                320
Ile Met Lys Arg Lys Glu Glu Ser Ser Tyr Lys Glu Ile Glu Pro Val 
                 325                330                335
Ala Ser Lys Arg Lys Glu Asn Ala Ile Lys Leu Lys Gly Glu Thr Lys 
             340                345                350
Thr Pro Lys Lys Thr Lys Ser Ser Pro Ala Lys Lys Glu Ser Val Ser 
         355                360                365
Pro Glu Asp Ser Glu Lys Lys Arg Thr Asn Tyr Gln Ala Tyr Arg Ser 
     370                375                380
Tyr Leu Asn Arg Glu Gly Pro Lys Ala Leu Gly Ser Lys Glu Ile Pro 
 385                390                395                400
Lys Gly Ala Glu Asn Cys Leu Glu Gly Leu Ile Phe Val Ile Thr Gly 
                 405                410                415
Val Leu Glu Ser Ile Glu Arg Asp Glu Ala Lys Ser Leu Ile Glu Arg 
             420                425                430
Tyr Gly Gly Lys Val Thr Gly Asn Val Ser Lys Lys Thr Asn Tyr Leu 
         435                440                445
Val Met Gly Arg Asp Ser Gly Gln Ser Lys Ser Asp Lys Ala Ala Ala 
     450                455                460
Leu Gly Thr Lys Ile Ile Asp Glu Asp Gly Leu Leu Asn Leu Ile Arg 
 465                470                475                480
Thr Met Pro Gly Lys Lys Ser Lys Tyr Glu Ile Ala Val Glu Thr Glu 
                 485                490                495
Met Lys Lys Glu Ser Lys Leu Glu Arg Thr Pro Gln Lys Asn Val Gln 
             500                505                510
Gly Lys Arg Lys Ile Ser Pro Ser Lys Lys Glu Ser Glu Ser Lys Lys 
         515                520                525
Ser Arg Pro Thr Ser Lys Arg Asp Ser Leu Ala Lys Thr Ile Lys Lys 
     530                535                540
Glu Thr Asp Val Phe Trp Lys Ser Leu Asp Phe Lys Glu Gln Val Ala 
 545                550                555                560
Glu Glu Thr Ser Gly Asp Ser Lys Ala Arg Asn Leu Ala Asp Asp Ser 
                 565                570                575
Ser Glu Asn Lys Val Glu Asn Leu Leu Trp Val Asp Lys Tyr Lys Pro 
             580                585                590
Thr Ser Leu Lys Thr Ile Ile Gly Gln Gln Gly Asp Gln Ser Cys Ala 
         595                600                605
Asn Lys Leu Leu Leu Trp Leu Arg Asn Trp Gln Lys Ser Ser Ser Glu 
     610                615                620
Asp Lys Lys His Ser Lys Phe Gly Lys Phe Ser Gly Lys Asp Asp Asn 
 625                630                635                640
Ser Ser Phe Lys Ala Ala Leu Leu Ser Gly Pro Pro Gly Val Gly Lys 
                 645                650                655
Thr Thr Thr Ala Ser Leu Val Cys Gln Glu Leu Gly Tyr Ser Tyr Val 
             660                665                670
Glu Leu Asn Arg Ser Asp Thr Arg Ser Lys Ser Ser Leu Lys Ala Ile 
         675                680                685
Val Ala Glu Ser Leu Asn Asn Thr Ser Ile Lys Gly Phe Tyr Ser Asn 
     690                695                700
Gly Ala Ala Ser Ser Val Ser Thr Lys His Ala Leu Ile Met Asp Glu 
 705                710                715                720
Val Asp Gly Met Ala Gly Asn Glu Asp Arg Gly Gly Ile Gln Glu Leu 
                 725                730                735
Ile Gly Leu Ile Lys His Thr Lys Ile Pro Ile Ile Cys Met Cys Asn 
             740                745                750
Asp Arg Asn His Pro Lys Ile Arg Ser Leu Val His Tyr Cys Phe Asp 
         755                760                765
Leu Arg Phe Gln Arg Pro Arg Val Glu Gln Ile Lys Gly Ala Met Met 
     770                775                780
Ser Ile Ala Phe Lys Glu Gly Leu Lys Ile Pro Pro Pro Ala Met Asn 
 785                790                795                800
Glu Ile Ile Leu Gly Ala Asn Gln Asp Ile Arg Gln Val Leu His Asn 
                 805                810                815
Leu Ser Met Trp Cys Ala Arg Ser Lys Ala Leu Thr Tyr Asp Gln Ala 
             820                825                830
Lys Ala Asp Ser His Arg Ala Lys Lys Asp Ile Lys Met Gly Pro Phe 
         835                840                845
Asp Val Ala Arg Lys Val Phe Ala Ala Gly Glu Glu Thr Ala His Met 
     850                855                860
Ser Leu Val Asp Lys Ser Asp Leu Phe Phe His Asp Tyr Ser Ile Ala 
 865                870                875                880
Pro Leu Phe Val Gln Glu Asn Tyr Ile His Val Lys Pro Val Ala Ala 
                 885                890                895
Gly Gly Asp Met Lys Lys His Leu Met Leu Leu Ser Arg Ala Ala Asp 
             900                905                910
Ser Ile Cys Asp Gly Asp Leu Val Asp Ser Gln Ile Arg Ser Lys Gln 
         915                920                925
Asn Trp Ser Leu Leu Pro Ala Gln Ala Ile Tyr Ala Ser Val Leu Pro 
     930                935                940
Gly Glu Leu Met Arg Gly Tyr Met Thr Gln Phe Pro Thr Phe Pro Ser 
 945                950                955                960
Trp Leu Gly Lys His Ser Ser Thr Gly Lys His Asp Arg Ile Val Gln 
                 965                970                975
Asp Leu Ala Leu His Met Ser Leu Arg Thr Tyr Ser Ser Lys Arg Thr 
             980                985                990
Val Asn Met Asp Tyr Leu Ser Leu Leu Arg Asp Ala Leu Val Gln Pro 
         995                1000                1005
Leu Thr Ser Gln Gly Val Asp Gly Val Gln Asp Val Val Ala Leu Met 
     1010                1015                1020
Asp Thr Tyr Tyr Leu Met Lys Glu Asp Phe Glu Asn Ile Met Glu Ile 
 1025                1030                1035                1040
Ser Ser Trp Gly Gly Lys Pro Ser Pro Phe Ser Lys Leu Asp Pro Lys 
                 1045                1050                1055
Val Lys Ala Ala Phe Thr Arg Ala Tyr Asn Lys Glu Ala His Leu Thr 
             1060                1065                1070
Pro Tyr Ala Leu Gln Ala Ile Lys Ala Ser Arg His Ser Thr Ser Pro 
         1075                1080                1085
Ser Leu Asp Ser Glu Tyr Asn Glu Glu Leu Asn Glu Asp Asp Ser Gln 
     1090                1095                1100
Ser Asp Glu Lys Asp Gln Asp Ala Ile Glu Thr Asp Ala Met Ile Lys 
 1105                1110                1115                1120
Lys Lys Thr Lys Ser Ser Lys Pro Ser Lys Pro Glu Lys Asp Lys Glu 
                 1125                1130                1135
Pro Arg Lys Gly Lys Gly Lys Ser Ser Lys Lys 
             1140                1145



<210> 4961
<211> 417
<212> DNA
<213> Rattus norvegicus
<308> AA859665
<400> 4961

ttttttttt  tttttttca  gaccttttt  gcttttatt  ttttggtag  tattcaagg  60
atgggcaga  gctcacaga  catcgccac  acagagaca  gttcctgac  gtgcccgtg  120
gtctgacgc  tgtcagctc  acaggcacg  ggctgcaca  cactgttct  aaatgcgtc  180
ctcatttca  ctttgggaa  ctgggcaga  ccaatgcga  caggccggg  ctgtggtaa  240
agacgcagc  gcttgcttg  taggaacca  ttctccatg  taaaggcaa  caaactttg  300
acagcacct  cctagatcc  cagcccaag  agcagacag  catgagcag  cacacgccg  360
aacgctcag  agagcgctg  cacccacct  aacaacagg  aagcagctt  gggctca  417



<210> 4962
<211> 455
<212> DNA
<213> Rattus norvegicus
<308> AA859688
<400> 4962

ttttttttt  tttttttgg  atacagaaa  agttttatt  tcttaatgc  gcacagtag  60
catacaatc  attattccc  agagtgtgc  atataaatt  ttcacatta  aaaattaac  120
acaaagcct  atatgcggg  aatattaaa  acatacacc  aatttttat  tgttctgac  180
gcggacatg  ctagcttta  aaatctgaa  aaataggac  tggcgcaca  tggcttgag  240
atagacggg  ctgctccag  tgtagtgag  acccactct  cactttggt  atcgagatt  300
cccgtggca  cgtggggcg  ctctgaaac  cttctggca  tccagggag  gcgtctcgg  360
cgctccccc  actctccct  gtancgagg  ggtcttttc  ccttgaaag  aagaagacc  420
tccagtctg  ccttcgttg  gatggtctg  gcata  455



<210> 4963
<211> 314
<212> PRT
<213> Rattus norvegicus
<308> NP_057918
<400> 4963

Met Ala Ala Ala Ala Pro Gly Ala Leu Gly Ala Leu Arg Thr Gly Arg 
  1               5                  10                  15
Val Arg Leu Val Ala Ala Cys Cys Ala Arg Leu Gly Pro Ala Ala Trp 
             20                  25                  30
Ala Arg Gly Thr Ala Pro Arg Arg Gly Tyr Ser Ser Glu Val Lys Thr 
         35                  40                  45
Glu Asp Glu Leu Arg Val Arg His Leu Glu Glu Glu Asn Arg Gly Ile 
     50                  55                  60
Val Val Leu Gly Ile Asn Arg Ala Tyr Gly Lys Asn Ala Leu Ser Lys 
 65                  70                  75                  80
Asn Leu Leu Lys Met Leu Ser Lys Ala Val Asp Ala Leu Lys Ser Asp 
                 85                  90                  95
Lys Lys Val Arg Thr Ile Ile Ile Arg Ser Glu Val Pro Gly Ile Phe 
             100                105                110
Cys Ala Gly Ala Asp Leu Lys Glu Arg Ala Lys Met His Ser Ser Glu 
         115                120                125
Val Gly Pro Phe Val Ser Lys Ile Arg Ser Val Ile Asn Asp Ile Ala 
     130                135                140
Asn Leu Pro Val Pro Thr Ile Ala Ala Ile Asp Gly Leu Ala Leu Gly 
 145                150                155                160
Gly Gly Leu Glu Leu Ala Leu Ala Cys Asp Ile Arg Val Ala Ala Ser 
                 165                170                175
Ser Ala Lys Met Gly Leu Val Glu Thr Lys Leu Ala Ile Ile Pro Gly 
             180                185                190
Gly Gly Gly Thr Gln Arg Leu Pro Arg Ala Ile Gly Met Ser Leu Ala 
         195                200                205
Lys Glu Leu Ile Phe Ser Ala Arg Val Leu Asp Gly Gln Glu Ala Lys 
     210                215                220
Ala Val Gly Leu Ile Ser His Val Leu Glu Gln Asn Gln Glu Gly Asp 
 225                230                235                240
Ala Ala Tyr Arg Lys Ala Leu Asp Leu Ala Arg Glu Phe Leu Pro Gln 
                 245                250                255
Gly Pro Val Ala Met Arg Val Ala Lys Leu Ala Ile Asn Gln Gly Met 
             260                265                270
Glu Val Asp Leu Val Thr Gly Leu Ala Ile Glu Glu Ala Cys Tyr Ala 
         275                280                285
Gln Thr Ile Ser Thr Lys Asp Arg Leu Glu Gly Leu Leu Ala Phe Lys 
     290                295                300
Glu Lys Arg Pro Pro Arg Tyr Lys Gly Glu 
 305                310



<210> 4964
<211> 1548
<212> DNA
<213> Homo sapiens
<308> X79888
<400> 4964

caacatggc  gccgcggtg  cggcggcac  tggggcctt  ggatccctg  atgctggcg  60
cgcccgcct  gtggccgct  gcagtgcgt  gctctgccc  gggttgagg  tgcccggct  120
gttggcagg  cggcgagcg  gcccggcga  ctgggccca  ggctgggta  ctgcggccg  180
gggtcccgc  ccgaaaagg  gctacagct  tgagatgaa  acggaggac  agctgcggg  240
gcggcacct  gaggaggag  accgaggaa  tgtggtgct  ggaataaac  gagcttatg  300
caaaaattc  ctcagtaaa  atcttataa  aatgctatc  aaagctgtg  atgctttga  360
atctgataa  aaagtacgg  ccataataa  caggagtga  gtcccaggg  tattctgtg  420
tggtgctga  cttaaggaa  gagccaaaa  gagttccag  gaagttggt  cttttgtct  480
caaaataag  gcagtgatt  acgatattg  taatcttcc  gtgccaaca  ttgcagcaa  540
agatggact  gctttaggt  gtggtcttg  actggcttt  gcctgtgat  tacgagtag  600
agcttcctc  gcaaaaatg  gcctggttg  aacaaaatt  gcgattatt  ctggtggag  660
ggggacaca  cgattgcca  gcgccattg  aatgtccct  gccaaggag  tcatattct  720
tgcgcgagt  ctcgatggc  aagaagcca  agcagtggg  ttaatcagc  acgttctgg  780
acagaacca  gagggagac  cggcctaca  gaaggcctt  gacctggcg  gagagtttt  840
acctcaggg  cctgttgca  tgagagtgg  aaaattagc  attaatcaa  ggatggagg  900
cgatttagt  acagggtta  ccatagaag  agcttgtta  gctcagacc  ttccaacaa  960
agacagact  gaaggtctt  ttgctttta  agagaaaag  ccccctcgc  ataaaggag  1020
ataaaagga  cagaaattc  taagatgcc  atgtaataa  tgtacttcc  ggaagtgtc  1080
ttcggatcc  ctatatgcc  cagcacatg  aaccttaat  accaaagtg  agagcagat  1140
attcatacg  tgtaataag  gtctggaat  gacccatcc  tgtacttca  tcaaatgtg  1200
aaatgtcat  ttcattcag  tttataaag  tagtagtgt  tagtcagaa  cagaatcaa  1260
gttagatat  catttttaa  tatttactg  atatgaggc  ttctgttaa  tttttaatg  1320
gaataattt  tatattgca  attctagga  taatattga  tgtatgtct  ctgtgctgc  1380
ttaagaaaa  aaaatttct  tataccaaa  atgtgaagt  ataccaaat  aagtttcta  1440
gtgattaat  catacgaac  gctacatat  catatatct  aacctgaaa  atgaattga  1500
attctgagt  aaaactacc  aatataaat  aaattagtg  aaagaaaa  1548



<210> 4965
<211> 339
<212> PRT
<213> Homo sapiens
<308> NP_001689
<400> 4965

Met Ala Ala Ala Val Ala Ala Ala Pro Gly Ala Leu Gly Ser Leu His 
  1               5                  10                  15
Ala Gly Gly Ala Arg Leu Val Ala Ala Cys Ser Ala Trp Leu Cys Pro 
             20                  25                  30
Gly Leu Arg Leu Pro Gly Ser Leu Ala Gly Arg Arg Ala Gly Pro Ala 
         35                  40                  45
Ile Trp Ala Gln Gly Trp Val Pro Ala Ala Gly Gly Pro Ala Pro Lys 
     50                  55                  60
Arg Gly Tyr Ser Ser Glu Met Lys Thr Glu Asp Glu Leu Arg Val Arg 
 65                  70                  75                  80
His Leu Glu Glu Glu Asn Arg Gly Ile Val Val Leu Gly Ile Asn Arg 
                 85                  90                  95
Ala Tyr Gly Lys Asn Ser Leu Ser Lys Asn Leu Ile Lys Met Leu Ser 
             100                105                110
Lys Ala Val Asp Ala Leu Lys Ser Asp Lys Lys Val Arg Thr Ile Ile 
         115                120                125
Ile Arg Ser Glu Val Pro Gly Ile Phe Cys Ala Gly Ala Asp Leu Lys 
     130                135                140
Glu Arg Ala Lys Met Ser Ser Ser Glu Val Gly Pro Phe Val Ser Lys 
 145                150                155                160
Ile Arg Ala Val Ile Asn Asp Ile Ala Asn Leu Pro Val Pro Thr Ile 
                 165                170                175
Ala Ala Ile Asp Gly Leu Ala Leu Gly Gly Gly Leu Glu Leu Ala Leu 
             180                185                190
Ala Cys Asp Ile Arg Val Ala Ala Ser Ser Ala Lys Met Gly Leu Val 
         195                200                205
Glu Thr Lys Leu Ala Ile Ile Pro Gly Gly Gly Gly Thr Gln Arg Leu 
     210                215                220
Pro Arg Ala Ile Gly Met Ser Leu Ala Lys Glu Leu Ile Phe Ser Ala 
 225                230                235                240
Arg Val Leu Asp Gly Lys Glu Ala Lys Ala Val Gly Leu Ile Ser His 
                 245                250                255
Val Leu Glu Gln Asn Gln Glu Gly Asp Ala Ala Tyr Arg Lys Ala Leu 
             260                265                270
Asp Leu Ala Arg Glu Phe Leu Pro Gln Gly Pro Val Ala Met Arg Val 
         275                280                285
Ala Lys Leu Ala Ile Asn Gln Gly Met Glu Val Asp Leu Val Thr Gly 
     290                295                300
Leu Ala Ile Glu Glu Ala Cys Tyr Ala Gln Thr Ile Pro Thr Lys Asp 
 305                310                315                320
Arg Leu Glu Gly Leu Leu Ala Phe Lys Glu Lys Arg Pro Pro Arg Tyr 
                 325                330                335
Lys Gly Glu 
             340



<210> 4966
<211> 436
<212> DNA
<213> Rattus norvegicus
<308> AA859690
<400> 4966

ttttttttt  tttttttac  accattcat  gaaatttta  tggacaaag  aaaatgctc  60
tcaataagc  aacaaccat  aaaacatgg  gcgtccgca  cactcagca  ggaagtcat  120
caatttctg  aacagagca  aaggtatta  actgagtga  agcatctcc  atgcttctg  180
caacacgct  ccatctcag  gctgcagag  tggaggaga  ttggtatgg  agcgaggta  240
gaagagtta  gtggtagtg  ggcagctgg  tgactataa  acagaatca  cgggccctc  300
ggagtactg  gctcgttct  tacattggt  atacataat  gcatgaatc  gcacacatg  360
taaaatagc  cgaagccac  tacatactg  tccaattaa  aagtccttg  ttttgatat  420
ttacaccat  tgttct  436



<210> 4967
<211> 522
<212> DNA
<213> Rattus norvegicus
<308> AA859693
<400> 4967

ttttttttt  tttttttct  tgtcagagc  agcccaatc  aggtgggct  ctgggaggg  60
ttactctca  tttctcctc  gacttttct  agaagccca  aaaaccacg  agaccagat  120
agtgtcctt  acatctcaa  tctacagta  tcggacagc  acgtcctaa  tcctgtcag  180
tacttcagg  taaaatcca  caagtgctg  tgagcccaa  gctaggcga  ggagaggtg  240
cttataact  atccctcat  gcctgcatc  tacttcctg  ctccagtca  tgccttccc  300
agtaatgag  taatgaaga  aataagagt  gatggaaat  accaagcag  aattacacg  360
tgccattag  aagcactat  aaaacaaaa  tacaggtta  cctcatttc  catgctcac  420
cctgtctaa  cagaaacac  agattaatc  aaccagtat  tgcaagagg  aaacctcaa  480
cagtaattt  aaattttaa  cctgtcagc  attcaaatt  tt  522



<210> 4968
<211> 2659
<212> DNA
<213> Homo sapiens
<308> AK001631
<400> 4968

catttggcc  ggggatggt  acacgcgcg  gggccggaa  tgccgtcgc  ggcgcggtc  60
ttgtcgcat  gctctcggc  gcactcgcg  tgtacgggc  gccactgga  gcagtttta  120
aaagagcgt  ttcgctacg  aaagcacat  cgataaagg  tatggaaaa  actttgcag  180
tggtgagaa  tatcatacc  cctctgtct  ccacaaagc  caaagggca  gatggaaga  240
taggcgtag  tggaggctg  caggagtac  ctggagccc  atattttgc  gcaatctca  300
ctctcaaag  gggcgcaga  ttgtcccac  tgttctgtg  cagtgcggc  gcacctgtg  360
ttaaggcct  cagcccgga  ctgatcgtc  acccagttc  tgacagccc  aatgctgtt  420
atgaggtgg  gaagtggct  ccccggctg  atgctcttg  cgtaggacc  ggcttgggt  480
gagatgatg  gcttctcag  aatgtccag  gcattttgg  agtgtcaaa  gccagggac  540
tccctgttg  catcgacgc  gatggcctg  ggctggtcg  tcagcagcc  gccctcatc  600
atggctacc  gaaggctgt  ctcactccc  accacgtgg  gttcagcag  ctgtatgac  660
ctgtgctca  aggccctat  gacagcgat  acagccatg  atctgtgct  agactcagc  720
aagccctgg  caacgtgac  gtggtccag  aaggagagc  cgacatcct  tccaacggc  780
agcaggtgc  tgtgtgcag  caggaaggc  gcagccgca  gtgtggagg  caaggggac  840
tcctgtcgg  ctccctggg  gtcctggta  actgggcgc  ccttgctgg  ccacagaaa  900
caaatgggg  catatcaga  ttgaaattg  caatttggg  tcctgagat  gaaacagga  960
tcaaaacca  agcccaggg  agctgcggc  cccggacca  gacgcccac  tccccacac  1020
tcctgctgt  cccctctcc  caggtccag  cctctcctg  tggccgcgt  tggcgcctg  1080
tctctcacc  ggcagtgca  ccaccaagc  ttccagaag  acggtcgct  caccaccac  1140
tccgacatg  tcgccgagg  gggggccgc  ttcagcaag  tctttgaaa  ctgagcccg  1200
gcagaccag  agtaaacag  caccttgga  gggggagag  gtgtgtgtg  tgggaaaat  1260
cggacccac  cgtgtgctg  aggcgtacg  tgcttgcca  attttcaac  tgagcataa  1320
ttggttgcc  ttgagaatt  aagaatctg  aatattgca  cttttggtt  aacttaatg  1380
atggttgga  atgttatgg  gacactaaa  aaagtattc  tgaactttc  ttagctcct  1440
ggtagtaac  gggaagacg  aaatgaaga  aatcacatg  gaatgaaga  ttctttagc  1500
gctcaacag  gtttctcgg  ctgctccca  atcggcgaa  tttctactt  ttactctct  1560
tgccggcgc  cttcgttcc  cctctgctt  ccttcccta  tctttcctc  ggcagggag  1620
tgggcaggg  tccccgggt  tctccctga  tcccgactg  actgactgg  tccatcaga  1680
ggctgcttc  ttctccagc  catcttctt  taaagtggt  actagcttg  tggtatctg  1740
ctgctggtg  ttggcttat  gacatactc  agggtaatc  atgatgact  tgtttggaa  1800
cccttttgg  ggcaccatg  gaacagaag  aaacatgag  gacgctgac  cttgagtgt  1860
tgggtgggg  gctctgaga  gcctcctgt  ccacgctct  cggtgtccg  gtctacaca  1920
gggtcccca  gatacccac  ggccccagc  gggcagacc  gaccgggga  gggcacggt  1980
aagggctgc  gcctggggt  tgacgtggc  cctagtgct  tctcaggag  aggctctgg  2040
ggacttgag  catgctggg  ctggtgcag  gatggcgct  aggagaccc  gggaaagac  2100
gtatcgtgg  cacgtatgc  taggaagca  cacagccgt  tccttaggg  tgttcgcgt  2160
cagtaaaga  actggtaac  gcggtttca  ccaacactc  tcatggcag  gtcgacctc  2220
ggttagctt  tgttgtctt  gtggatggt  ttcctggag  ggcctgacg  tgacgtgtt  2280
tctggtccc  tgtcttagc  gggcatggt  cggtttcgt  cctgacgcg  gcattaggg  2340
gttctctta  actttcagt  gcatctttc  acagcaagg  ccaaaccct  ctggttccc  2400
tcagagtct  tttggcctg  tgatgactc  tgagtgata  cctgtgatg  agacatgcc  2460
cagatggat  ctactttct  taaaactag  gactttcaa  attaaaaaa  agattgtca  2520
tactaattt  acgcctaac  tcagaagct  cactgccta  atgtgaact  ttccagaaa  2580
actgtgcca  ggacatttt  cctctgggg  attaacatc  aaattctgg  aactattaa  2640
agacagatc  ggttaattt  2659



<210> 4969
<211> 391
<212> PRT
<213> Homo sapiens
<308> AK001631
<400> 4969

Met Val Thr Arg Ala Gly Ala Gly Thr Ala Val Ala Gly Ala Val Val 
  1               5                  10                  15
Val Ala Leu Leu Ser Ala Ala Leu Ala Leu Tyr Gly Pro Pro Leu Asp 
             20                  25                  30
Ala Val Leu Glu Arg Ala Phe Ser Leu Arg Lys Ala His Ser Ile Lys 
         35                  40                  45
Asp Met Glu Asn Thr Leu Gln Leu Val Arg Asn Ile Ile Pro Pro Leu 
     50                  55                  60
Ser Ser Thr Lys His Lys Gly Gln Asp Gly Arg Ile Gly Val Val Gly 
 65                  70                  75                  80
Gly Cys Gln Glu Tyr Thr Gly Ala Pro Tyr Phe Ala Ala Ile Ser Ala 
                 85                  90                  95
Leu Lys Val Gly Ala Asp Leu Ser His Val Phe Cys Ala Ser Ala Ala 
             100                105                110
Ala Pro Val Ile Lys Ala Tyr Ser Pro Glu Leu Ile Val His Pro Val 
         115                120                125
Leu Asp Ser Pro Asn Ala Val His Glu Val Glu Lys Trp Leu Pro Arg 
     130                135                140
Leu His Ala Leu Val Val Gly Pro Gly Leu Gly Arg Asp Asp Ala Leu 
 145                150                155                160
Leu Arg Asn Val Gln Gly Ile Leu Glu Val Ser Lys Ala Arg Asp Ile 
                 165                170                175
Pro Val Val Ile Asp Ala Asp Gly Leu Trp Leu Val Ala Gln Gln Pro 
             180                185                190
Ala Leu Ile His Gly Tyr Arg Lys Ala Val Leu Thr Pro Asp His Val 
         195                200                205
Glu Phe Ser Arg Leu Tyr Asp Ala Val Leu Arg Gly Pro Met Asp Ser 
     210                215                220
Asp Asp Ser His Gly Ser Val Leu Arg Leu Ser Gln Ala Leu Gly Asn 
 225                230                235                240
Val Thr Val Val Gln Lys Gly Glu Arg Asp Ile Leu Ser Asn Gly Gln 
                 245                250                255
Gln Val Leu Val Cys Ser Gln Glu Gly Ser Ser Arg Arg Cys Gly Gly 
             260                265                270
Gln Gly Asp Leu Leu Ser Gly Ser Leu Gly Val Leu Val His Trp Ala 
         275                280                285
Leu Leu Ala Gly Pro Gln Lys Thr Asn Gly Gly Ile Ser Asp Leu Lys 
     290                295                300
Leu Thr Ile Trp Gly Pro Glu Ile Glu Thr Gly Val Lys Thr Arg Ala 
 305                310                315                320
Gln Gly Ser Cys Gly Pro Arg Thr Thr Thr Pro Thr Ser Pro His Leu 
                 325                330                335
Leu Leu Ser Pro Ser Pro Gln Val Gln Pro Ser Pro Gly Gly Arg Val 
             340                345                350
Trp Arg Leu Leu Ser His Gln Ala Val Gln Pro Pro Ser Leu Pro Glu 
         355                360                365
Ala Arg Ser Leu His His His Leu Arg His Asp Arg Arg Gly Gly Gly 
     370                375                380
Arg Leu Gln Gln Ala Leu Ter 
 385                390



<210> 4970
<211> 485
<212> DNA
<213> Rattus norvegicus
<308> AA859702
<400> 4970

cggccgcga  gaagagcgg  ggaagctgg  cgacatcat  caccactgg  acgccaacc  60
gctggacct  ttcgagatc  gccagccga  cgaggattt  gagtttcat  gagtcatga  120
attttattt  caagataaa  ctgctggaa  ctttgcaac  aaatgtatt  gggtctcta  180
cacagcaac  actcaagat  tcattgaaa  actggcaga  aagttccgc  ctgatatgc  240
catgctctc  tctcccaag  actccctct  tgaagtgca  gtcagtgga  aaagaagat  300
ggacattga  gagaaacct  tagttgtac  gttgaattg  aacaaagat  atcgggagg  360
tagattcgt  cttaagaac  agaatgacg  cattcctgc  aagaaggct  aaagtaatg  420
acctgagaa  caggagaaa  aaggtgtta  tcagaactt  aaaagaact  tgtcaaaga  480
aaaaa  485



<210> 4971
<211> 442
<212> PRT
<213> Rattus norvegicus
<308> Q01205
<400> 4971

Met Arg Ser Leu Ser Ala Phe Gln Lys Gly Asn Cys Pro Leu Gly Arg 
  1               5                  10                  15
Arg Ser Leu Pro Gly Val Ser Leu Cys Gln Gly Pro Gly Tyr Pro Asp 
             20                  25                  30
Ser Arg Lys Met Val Ile Asn Thr Val Ala Val Phe Ser Val Arg Phe 
         35                  40                  45
Phe Gln Thr Thr Ala Val Cys Lys Asn Asp Val Ile Thr Val Gln Thr 
     50                  55                  60
Pro Ala Phe Ala Glu Ser Val Thr Glu Gly Asp Val Arg Trp Glu Lys 
 65                  70                  75                  80
Ala Val Gly Asp Ala Val Ala Glu Asp Glu Val Val Cys Glu Ile Glu 
                 85                  90                  95
Thr Asp Lys Thr Ser Val Gln Val Pro Ser Pro Ala Asn Gly Ile Ile 
             100                105                110
Glu Ala Leu Leu Val Pro Asp Gly Gly Lys Val Glu Gly Gly Thr Pro 
         115                120                125
Leu Phe Thr Leu Arg Lys Thr Gly Ala Ala Pro Ala Lys Ala Lys Pro 
     130                135                140
Ala Glu Ala Pro Ala Thr Ala His Lys Ala Ala Pro Glu Ala Pro Ala 
 145                150                155                160
Ala Pro Pro Pro Pro Val Ala Pro Val Pro Thr Gln Met Pro Pro Val 
                 165                170                175
Pro Ser Pro Ser Gln Pro Pro Ser Ser Lys Pro Val Ser Ala Ile Lys 
             180                185                190
Pro Thr Ala Ala Pro Pro Leu Ala Glu Ala Gly Ala Ala Lys Gly Leu 
         195                200                205
Arg Ser Glu His Arg Glu Lys Met Asn Arg Met Arg Gln Arg Ile Ala 
     210                215                220
Gln Arg Leu Lys Glu Ala Gln Asn Thr Cys Ala Met Leu Thr Thr Phe 
 225                230                235                240
Asn Glu Val Asp Met Ser Asn Ile Gln Glu Met Arg Ala Arg His Lys 
                 245                250                255
Asp Ala Phe Leu Lys Lys His Asn Leu Lys Leu Gly Leu Met Ser Ala 
             260                265                270
Phe Val Lys Ala Ser Ala Phe Ala Leu Gln Glu Gln Pro Val Val Asn 
         275                280                285
Ala Val Ile Asp Asp Ala Thr Lys Glu Val Val Tyr Arg Asp Tyr Ile 
     290                295                300
Asp Ile Ser Val Ala Val Ala Thr Pro Arg Gly Leu Val Val Pro Val 
 305                310                315                320
Ile Arg Asn Val Glu Thr Met Asn Tyr Ala Asp Ile Glu Arg Thr Ile 
                 325                330                335
Asn Glu Leu Gly Glu Lys Ala Arg Lys Asn Glu Leu Ala Ile Glu Asp 
             340                345                350
Met Asp Gly Gly Thr Phe Thr Ile Ser Asn Gly Gly Val Phe Gly Ser 
         355                360                365
Leu Phe Gly Thr Pro Ile Ile Asn Pro Pro Gln Ser Ala Ile Leu Gly 
     370                375                380
Met His Gly Ile Phe Asp Arg Pro Val Ala Val Gly Gly Lys Val Glu 
 385                390                395                400
Val Arg Pro Met Met Tyr Val Ala Leu Thr Tyr Asp His Arg Leu Ile 
                 405                410                415
Asp Gly Arg Glu Ala Val Thr Phe Leu Arg Lys Ile Lys Ala Ala Val 
             420                425                430
Glu Asp Pro Ala Val Leu Leu Leu Asp Leu 
         435                440



<210> 4972
<211> 510
<212> DNA
<213> Homo sapiens
<308> AI184508
<400> 4972

ttttatggg  ataagtgtt  tttatttta  aaagcacca  tgcttacag  caaaactgt  60
atagacatg  cttgggagg  aaaaataca  atatatgaa  tatggcttg  aaatttctg  120
atatcagta  ttaacagcg  ttttaaaac  ctgccatca  accaatctt  agtgtaaga  180
agaaacaaa  ctgcatcac  tcttcaagt  ctaaggatc  atttcactt  atggtaccc  240
caaaatact  gccagctct  tgttctcac  cagaaggtg  ctttcataa  ctgcacctt  300
aaaatatat  gtccaagta  ctggtgaac  tgtgtgagg  attaacctg  aaaatcctc  360
ctggcacag  gggtctaaa  attcttgta  accatttgg  atgtttctg  caacatcac  420
agaataacc  tcttctggc  aaagaaacg  cagctgcag  tcaggatcc  cctccaact  480
cacttccct  ccatcactg  gggccagctc  510



<210> 4973
<211> 1816
<212> PRT
<213> Homo sapiens
<308> P55196
<400> 4973

Met Ser Ala Gly Gly Arg Asp Glu Glu Arg Arg Lys Leu Ala Asp Ile 
  1               5                  10                  15
Ile His His Trp Asn Ala Asn Arg Leu Asp Leu Phe Glu Ile Ser Gln 
             20                  25                  30
Pro Thr Glu Asp Leu Glu Phe His Gly Val Met Arg Phe Tyr Phe Gln 
         35                  40                  45
Asp Lys Ala Ala Gly Asn Phe Ala Thr Lys Cys Ile Arg Val Ser Ser 
     50                  55                  60
Thr Ala Thr Thr Gln Asp Val Ile Glu Thr Leu Ala Glu Lys Phe Arg 
 65                  70                  75                  80
Pro Asp Met Arg Met Leu Ser Ser Pro Lys Tyr Ser Leu Tyr Glu Val 
                 85                  90                  95
His Val Ser Gly Glu Arg Arg Leu Asp Ile Asp Glu Lys Pro Leu Val 
             100                105                110
Val Gln Leu Asn Trp Asn Lys Asp Asp Arg Glu Gly Arg Phe Val Leu 
         115                120                125
Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys Ala Gln Ser Asn Gly Pro 
     130                135                140
Glu Lys Gln Glu Lys Glu Gly Val Ile Gln Asn Phe Lys Arg Thr Leu 
 145                150                155                160
Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys Arg Glu Lys Glu Ala Leu 
                 165                170                175
Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro Phe Gln Gly Glu Asp Val 
             180                185                190
Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr Lys Asp Met Pro Glu Thr 
         195                200                205
Ser Phe Thr Arg Thr Ile Ser Asn Pro Glu Val Val Met Lys Arg Arg 
     210                215                220
Arg Gln Gln Lys Leu Glu Lys Arg Met Gln Glu Phe Arg Ser Ser Asp 
 225                230                235                240
Gly Arg Pro Asp Ser Gly Gly Thr Leu Arg Ile Tyr Ala Asp Ser Leu 
                 245                250                255
Lys Pro Asn Ile Pro Tyr Lys Thr Ile Leu Leu Ser Thr Thr Asp Pro 
             260                265                270
Ala Asp Phe Ala Val Ala Glu Ala Leu Glu Lys Tyr Gly Leu Glu Lys 
         275                280                285
Glu Asn Pro Lys Asp Tyr Cys Ile Ala Arg Val Met Leu Pro Pro Gly 
     290                295                300
Ala Gln His Ser Asp Glu Lys Gly Ala Lys Glu Ile Ile Leu Asp Asp 
 305                310                315                320
Asp Glu Cys Pro Leu Gln Ile Phe Arg Glu Trp Pro Ser Asp Lys Gly 
                 325                330                335
Ile Leu Val Phe Gln Leu Lys Arg Arg Pro Pro Asp His Ile Pro Lys 
             340                345                350
Lys Thr Lys Lys His Leu Glu Gly Lys Thr Pro Lys Gly Lys Glu Arg 
         355                360                365
Ala Asp Gly Ser Gly Tyr Gly Ser Thr Leu Pro Pro Glu Lys Leu Pro 
     370                375                380
Tyr Leu Val Glu Leu Ser Pro Asp Gly Ser Asp Ser Arg Asp Lys Pro 
 385                390                395                400
Lys Leu Tyr Arg Leu Gln Leu Ser Val Thr Glu Val Gly Thr Glu Lys 
                 405                410                415
Leu Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro Gly Ile Gln Pro His 
             420                425                430
His Cys Asp Leu Thr Asn Met Asp Gly Val Val Thr Val Thr Pro Arg 
         435                440                445
Ser Met Asp Ala Glu Thr Tyr Val Glu Gly Gln Arg Ile Ser Glu Thr 
     450                455                460
Thr Met Leu Gln Ser Gly Met Lys Val Gln Phe Gly Ala Ser His Val 
 465                470                475                480
Phe Lys Phe Val Asp Pro Ser Gln Asp His Ala Leu Ala Lys Arg Ser 
                 485                490                495
Val Asp Gly Gly Leu Met Val Lys Gly Pro Arg His Lys Pro Gly Ile 
             500                505                510
Val Gln Glu Thr Thr Phe Asp Leu Gly Gly Asp Ile His Ser Gly Thr 
         515                520                525
Ala Leu Pro Thr Ser Lys Ser Thr Thr Arg Leu Asp Ser Asp Arg Val 
     530                535                540
Ser Ser Ala Ser Ser Thr Ala Glu Arg Gly Met Val Lys Pro Met Ile 
 545                550                555                560
Arg Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln Glu Ser Arg Thr Gln 
                 565                570                575
Asp Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala Ser Ile Glu Phe Arg 
             580                585                590
Glu Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile Ile Asn Tyr Thr Asn 
         595                600                605
Ser Ser Thr Val His Phe Lys Leu Ser Pro Thr Tyr Val Leu Tyr Met 
     610                615                620
Ala Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg Pro Asp Ile Ser Pro 
 625                630                635                640
Thr Glu Arg Thr His Lys Val Ile Ala Val Val Asn Lys Met Val Ser 
                 645                650                655
Met Met Glu Gly Val Ile Gln Lys Gln Lys Asn Ile Ala Gly Ala Leu 
             660                665                670
Ala Phe Trp Met Ala Asn Ala Ser Glu Leu Leu Asn Phe Ile Lys Gln 
         675                680                685
Asp Arg Asp Leu Ser Arg Ile Thr Leu Asp Ala Gln Asp Val Leu Ala 
     690                695                700
His Leu Val Gln Met Ala Phe Lys Tyr Leu Val His Cys Leu Gln Ser 
 705                710                715                720
Glu Leu Asn Asn Tyr Met Pro Ala Phe Leu Asp Asp Pro Glu Glu Asn 
                 725                730                735
Ser Leu Gln Arg Pro Lys Ile Asp Asp Val Leu His Thr Leu Thr Gly 
             740                745                750
Ala Met Ser Leu Leu Arg Arg Cys Arg Val Asn Ala Ala Leu Thr Ile 
         755                760                765
Gln Leu Phe Ser Gln Leu Phe His Phe Ile Asn Met Trp Leu Phe Asn 
     770                775                780
Arg Leu Val Thr Asp Pro Asp Ser Gly Leu Cys Ser His Tyr Trp Gly 
 785                790                795                800
Ala Ile Ile Arg Gln Gln Leu Gly His Ile Glu Ala Trp Ala Glu Lys 
                 805                810                815
Gln Gly Leu Glu Leu Ala Ala Asp Cys His Leu Ser Arg Ile Val Gln 
             820                825                830
Ala Thr Thr Leu Leu Thr Met Asp Lys Tyr Ala Pro Asp Asp Ile Pro 
         835                840                845
Asn Ile Asn Ser Thr Cys Phe Lys Leu Asn Ser Leu Gln Leu Gln Ala 
     850                855                860
Leu Leu Gln Asn Tyr His Cys Ala Pro Asp Glu Pro Phe Ile Pro Thr 
 865                870                875                880
Asp Leu Ile Glu Asn Val Val Thr Val Ala Glu Asn Thr Ala Asp Glu 
                 885                890                895
Leu Ala Arg Ser Asp Gly Arg Glu Val Gln Leu Glu Glu Asp Pro Asp 
             900                905                910
Leu Gln Leu Pro Phe Leu Leu Pro Glu Asp Gly Tyr Ser Cys Asp Val 
         915                920                925
Val Arg Asn Ile Pro Asn Gly Leu Gln Glu Phe Leu Asp Pro Leu Cys 
     930                935                940
Gln Arg Gly Phe Cys Arg Leu Ile Pro His Thr Arg Ser Pro Gly Thr 
 945                950                955                960
Trp Thr Ile Tyr Phe Glu Gly Ala Asp Tyr Glu Ser His Leu Leu Arg 
                 965                970                975
Glu Asn Thr Glu Leu Ala Gln Pro Leu Arg Lys Glu Pro Glu Ile Ile 
             980                985                990
Thr Val Thr Leu Lys Lys Gln Asn Gly Met Gly Leu Ser Ile Val Ala 
         995                1000                1005
Ala Lys Gly Ala Gly Gln Asp Lys Leu Gly Ile Tyr Val Lys Ser Val 
     1010                1015                1020
Val Lys Gly Gly Ala Ala Asp Asp Gly Arg Leu Ala Ala Gly Asp Gln 
 1025                1030                1035                1040
Leu Leu Ser Val Asp Gly Arg Ser Leu Val Gly Leu Ser Gln Glu Arg 
                 1045                1050                1055
Ala Ala Glu Leu Met Thr Arg Thr Ser Ser Val Val Thr Leu Glu Val 
             1060                1065                1070
Ala Lys Gln Gly Ala Ile Tyr His Gly Leu Ala Thr Leu Leu Asn Gln 
         1075                1080                1085
Pro Ser Pro Met Met Gln Arg Ile Ser Asp Arg Arg Gly Ser Gly Lys 
     1090                1095                1100
Pro Arg Pro Lys Ser Glu Gly Phe Glu Leu Tyr Asn Asn Ser Thr Gln 
 1105                1110                1115                1120
Asn Gly Ser Pro Glu Ser Pro Gln Leu Pro Trp Ala Glu Tyr Ser Glu 
                 1125                1130                1135
Pro Lys Lys Leu Pro Gly Asp Asp Arg Leu Met Lys Asn Arg Ala Asp 
             1140                1145                1150
His Arg Ser Ser Pro Asn Val Ala Asn Gln Pro Pro Ser Pro Gly Gly 
         1155                1160                1165
Lys Ser Ala Tyr Ala Ser Gly Thr Thr Ala Lys Ile Thr Ser Val Ser 
     1170                1175                1180
Thr Gly Asn Leu Cys Thr Glu Glu Gln Thr Pro Pro Pro Arg Pro Glu 
 1185                1190                1195                1200
Ala Tyr Pro Ile Pro Thr Gln Thr Tyr Thr Arg Glu Tyr Phe Thr Phe 
                 1205                1210                1215
Pro Ala Ser Lys Ser Gln Asp Arg Met Ala Pro Pro Gln Asn Gln Trp 
             1220                1225                1230
Pro Asn Tyr Glu Glu Lys Pro His Met His Thr Asp Ser Asn His Ser 
         1235                1240                1245
Ser Ile Ala Ile Gln Arg Val Thr Arg Ser Gln Glu Glu Leu Arg Glu 
     1250                1255                1260
Asp Lys Ala Tyr Gln Leu Glu Arg His Arg Ile Glu Ala Ala Met Asp 
 1265                1270                1275                1280
Arg Lys Ser Asp Ser Asp Met Trp Ile Asn Gln Ser Ser Ser Leu Asp 
                 1285                1290                1295
Ser Ser Thr Ser Ser Gln Glu His Leu Asn His Ser Ser Lys Ser Val 
             1300                1305                1310
Thr Pro Ala Ser Thr Leu Thr Lys Ser Gly Pro Gly Arg Trp Lys Thr 
         1315                1320                1325
Pro Ala Ala Ile Pro Ala Thr Pro Val Ala Val Ser Gln Pro Ile Arg 
     1330                1335                1340
Thr Asp Leu Pro Pro Pro Pro Pro Pro Pro Pro Val His Tyr Ala Gly 
 1345                1350                1355                1360
Asp Phe Asp Gly Met Ser Met Asp Leu Pro Leu Pro Pro Pro Pro Ser 
                 1365                1370                1375
Ala Asn Gln Ile Gly Leu Pro Ser Ala Gln Val Ala Ala Ala Glu Arg 
             1380                1385                1390
Arg Lys Arg Glu Glu His Gln Arg Trp Tyr Glu Lys Glu Lys Ala Arg 
         1395                1400                1405
Leu Glu Glu Glu Arg Glu Arg Lys Arg Arg Glu Gln Glu Arg Lys Leu 
     1410                1415                1420
Gly Gln Met Arg Thr Gln Ser Leu Asn Pro Ala Pro Phe Ser Pro Leu 
 1425                1430                1435                1440
Thr Ala Gln Gln Met Lys Pro Glu Lys Pro Ser Thr Leu Gln Arg Pro 
                 1445                1450                1455
Gln Glu Thr Val Ile Arg Glu Leu Gln Pro Gln Gln Gln Pro Arg Thr 
             1460                1465                1470
Ile Glu Arg Arg Asp Leu Gln Tyr Ile Thr Val Ser Lys Glu Glu Leu 
         1475                1480                1485
Ser Ser Gly Asp Ser Leu Ser Pro Asp Pro Trp Lys Arg Asp Ala Lys 
     1490                1495                1500
Glu Lys Leu Glu Lys Gln Gln Gln Met His Ile Val Asp Met Leu Ser 
 1505                1510                1515                1520
Lys Glu Ile Gln Glu Leu Gln Ser Lys Pro Asp Arg Ser Ala Glu Glu 
                 1525                1530                1535
Ser Asp Arg Leu Arg Lys Leu Met Leu Glu Trp Gln Phe Gln Lys Arg 
             1540                1545                1550
Leu Gln Glu Ser Lys Gln Lys Asp Glu Asp Asp Glu Glu Glu Glu Asp 
         1555                1560                1565
Asp Asp Val Asp Thr Met Leu Ile Met Gln Arg Leu Glu Ala Glu Arg 
     1570                1575                1580
Arg Ala Arg Leu Gln Asp Glu Glu Arg Arg Arg Gln Gln Gln Leu Glu 
 1585                1590                1595                1600
Glu Met Arg Lys Arg Glu Ala Glu Asp Arg Ala Arg Gln Glu Glu Glu 
                 1605                1610                1615
Arg Arg Arg Gln Glu Glu Glu Arg Thr Lys Arg Asp Ala Glu Glu Lys 
             1620                1625                1630
Arg Arg Gln Glu Glu Gly Tyr Tyr Ser Arg Leu Glu Ala Glu Arg Arg 
         1635                1640                1645
Arg Gln His Asp Glu Ala Ala Arg Arg Leu Leu Glu Pro Glu Ala Pro 
     1650                1655                1660
Gly Leu Cys Arg Pro Pro Leu Pro Arg Asp Tyr Glu Pro Pro Ser Pro 
 1665                1670                1675                1680
Ser Pro Ala Pro Gly Ala Pro Pro Pro Pro Pro Gln Arg Asn Ala Ser 
                 1685                1690                1695
Tyr Leu Lys Thr Gln Val Leu Ser Pro Asp Ser Leu Phe Thr Ala Lys 
             1700                1705                1710
Phe Val Ala Tyr Asn Glu Glu Glu Glu Glu Glu Asp Cys Ser Leu Ala 
         1715                1720                1725
Gly Gln Asp Lys Tyr Ser Ser Thr Arg Lys Ser His Gly Asp Leu Leu 
     1730                1735                1740
Pro Ala Pro Leu Lys Pro Arg Pro Pro Pro Cys Gln Pro Arg Pro Ala 
 1745                1750                1755                1760
Ser Asp Gly Val Phe Leu Ser Asn Ser Phe Gln Pro Pro Ser Ala Lys 
                 1765                1770                1775
Ala Asn Ser Thr Ala His Lys Lys Gly Gln Pro Leu Pro Pro Pro Lys 
             1780                1785                1790
Lys Ser Ser Ser Tyr His Pro Ser His Cys Lys Gly Arg Gly Lys Arg 
         1795                1800                1805
Val Thr Asn Gln Leu Ser Leu Ser 
     1810                1815



<210> 4974
<211> 493
<212> DNA
<213> Rattus norvegicus
<308> AA859718
<400> 4974

ttttttttt  ttttattga  acggtttct  tgcagccct  gctgtcctg  agctcgggc  60
ccagactgg  ctcaaactt  cagagctcc  cctgtctct  cctcccaag  gctgggatt  120
aaggtgtgt  ccaccactc  ttagttgat  tgaatcagg  accggcttg  agggctagc  180
atgaaagtc  agcagcctc  tttgcacta  aaggtccat  ctgatggac  caacagtct  240
gggctagtg  ggtcttacg  ccaaacact  ccttcttac  ccgtgacag  gtttacctg  300
atcagcgaa  gtctgctcc  gcactcgaa  gagcaggtc  accgccctt  ggacaccag  360
ctctttaga  gctaagcgt  agccataac  tgcttcttc  gaagaggcc  gtagaagag  420
tgctgtggt  atgttagca  acacctctc  gtgctttca  gccgcttgt  aataaagtg  480
ctttggggg  tgg  493



<210> 4975
<211> 531
<212> DNA
<213> Rattus norvegicus
<308> AA859719
<400> 4975

ttttttttt  tttttttgg  agtatagca  ctcatttac  ctgaacatt  attacacat  60
tacgccaaa  atattttag  aattgttga  agggaaagt  cttaaaaaa  aaaatgaca  120
caaaaaccc  agagatgca  caaagatag  attataaac  cattacaat  cttaacaaa  180
acagatccg  gccacacaa  aatcattga  atgtctaag  cactaggca  caggtaagc  240
ttaaatgtt  gttcctcac  actaacttg  gatccagtg  cttcctctt  ccttcagta  300
caggcccag  ccacacgga  cacaggttt  catgcatat  aaacactga  aacgcatta  360
tgggaaatt  taaaggatg  aacaactat  tagcagttc  ttaattcac  gtcacataa  420
gttgaccct  aatatttag  atattctgt  taactctcc  tctattgtt  tccaaaaag  480
gatagtaac  gcagaccag  gacactaag  tagctcaag  atatagcat  g  531



<210> 4976
<211> 128
<212> PRT
<213> Rattus norvegicus
<308> NP_079750
<400> 4976

Met Ala Ala Ser Val Leu Gly Ser Leu Leu Arg Thr Phe Arg Gln Ala 
  1               5                  10                  15
Val Pro Pro Ser Ala Ser Gly Gln Val Arg Gly Tyr Tyr Val Asp Trp 
             20                  25                  30
Arg Met Leu Arg Asp Leu Lys Arg Arg Lys Met Ala Tyr Glu Tyr Ala 
         35                  40                  45
Asp Glu Arg Leu Arg Ile Asn Ser Leu Arg Lys Asn Thr Ile Leu Pro 
     50                  55                  60
Lys Asp Leu Gln Glu Met Ala Gly Asp Glu Ile Ala Ala Leu Pro Arg 
 65                  70                  75                  80
Asp Ser Cys Pro Val Arg Ile Arg Asn Arg Cys Val Met Thr Ser Arg 
                 85                  90                  95
Pro Arg Gly Val Lys Arg Arg Trp Arg Leu Ser Arg Ile Val Phe Arg 
             100                105                110
His Leu Ala Asp His Gly Leu Leu Ser Gly Val Gln Arg Ala Ile Trp 
         115                120                125



<210> 4977
<211> 435
<212> DNA
<213> Rattus norvegicus
<308> AA859740
<400> 4977

ttttttttt  tttttttgg  ctagtgccc  atcccttac  ttctttaag  ggccctggc  60
agcccttag  ggaggtgcc  tgacttttt  agagtccat  tgcatgcag  caagggttg  120
gagctgtcc  tgagatagg  cagggccca  tccctgcct  tgcctcact  tgcactcag  180
ctaagaagg  gagggtcac  acagacagg  gtgggggcc  ttatgtagc  cagcaatat  240
ctagatgtt  gcaggtgtc  ctgctgccc  agagcaatg  cttaatctt  acgtgtgtg  300
tataggatc  ggcactggg  acttgacct  ggggtccat  ggcaagatg  gttctgatt  360
tgcactgtc  ggcccaatc  agggccacc  ttatggtgg  tgatcactc  gaagatatg  420
gtggcaaga  gagtt  435



<210> 4978
<211> 401
<212> PRT
<213> Rattus norvegicus
<308> BAA89248
<400> 4978

Met Val Glu Arg Ala Ser Lys Phe Val Leu Val Val Ala Gly Ser Ala 
  1               5                  10                  15
Cys Phe Met Leu Ile Leu Tyr Gln Tyr Ala Gly Pro Gly Leu Ser Leu 
             20                  25                  30
Gly Ala Pro Gly Gly Arg Val Pro Pro Asp Asp Leu Asp Leu Phe Pro 
         35                  40                  45
Thr Pro Asp Pro His Tyr Glu Lys Lys Tyr Tyr Phe Pro Val Arg Glu 
     50                  55                  60
Leu Glu Arg Ser Leu Arg Phe Asp Met Lys Gly Asp Asp Val Ile Val 
 65                  70                  75                  80
Phe Leu His Ile Gln Lys Thr Gly Gly Thr Thr Phe Gly Arg His Leu 
                 85                  90                  95
Val Gln Asn Val Arg Leu Glu Val Pro Cys Asp Cys Arg Pro Gly Gln 
             100                105                110
Lys Lys Cys Thr Cys Tyr Arg Pro Asn Arg Arg Glu Thr Trp Leu Phe 
         115                120                125
Ser Arg Phe Ser Thr Gly Trp Ser Cys Gly Leu His Ala Asp Trp Thr 
     130                135                140
Glu Leu Thr Asn Cys Val Pro Gly Val Leu Asp Arg Arg Asp Pro Ala 
 145                150                155                160
Gly Leu Arg Ser Pro Arg Lys Phe Tyr Tyr Ile Thr Leu Leu Arg Asp 
                 165                170                175
Pro Val Ser Arg Tyr Leu Ser Glu Trp Arg His Val Gln Arg Gly Ala 
             180                185                190
Thr Trp Lys Thr Ser Leu His Met Cys Asp Gly Arg Thr Pro Thr Pro 
         195                200                205
Glu Glu Leu Pro Pro Cys Tyr Glu Gly Thr Asp Trp Ser Gly Cys Thr 
     210                215                220
Leu Gln Glu Phe Met Asp Cys Pro Tyr Asn Leu Ala Asn Asn Arg Gln 
 225                230                235                240
Val Arg Met Leu Ala Asp Leu Ser Leu Val Gly Cys Tyr Asn Leu Ser 
                 245                250                255
Phe Ile Pro Glu Ser Lys Arg Ala Gln Leu Leu Leu Glu Ser Ala Lys 
             260                265                270
Lys Asn Leu Arg Gly Met Ala Phe Phe Gly Leu Thr Glu Phe Gln Arg 
         275                280                285
Lys Thr Gln Tyr Leu Phe Glu Arg Thr Phe Asn Leu Lys Phe Ile Arg 
     290                295                300
Pro Phe Met Gln Tyr Asn Ser Thr Arg Ala Gly Gly Val Glu Val Asp 
 305                310                315                320
Glu Asp Thr Ile Arg His Ile Glu Glu Leu Asn Asp Leu Asp Met Gln 
                 325                330                335
Leu Tyr Asp Tyr Ala Lys Asp Leu Phe Gln Gln Arg Tyr Gln Tyr Lys 
             340                345                350
Arg Gln Leu Glu Arg Arg Glu Gln Arg Leu Arg Asn Arg Glu Glu Arg 
         355                360                365
Leu Leu His Arg Ser Lys Glu Ala Leu Pro Arg Glu Asp Pro Glu Glu 
     370                375                380
Pro Gly Arg Val Pro Thr Glu Asp Tyr Met Ser His Ile Ile Glu Lys 
 385                390                395                400
Trp 
                 405



<210> 4979
<211> 2055
<212> DNA
<213> Homo sapiens
<308> XM_017698
<400> 4979

ggcgccgag  agccgggcc  ggccggagc  cgggcggcg  cggaggcag  tgcgcccgc  60
cctcctgcc  tcccaggcc  cgcgccccg  gcccgggcc  cggcgatgg  gacacatgc  120
gcggcggcg  gccggcggc  ggaccatgg  tgagcgcgc  agcaagttc  tgctggtgg  180
ggcgggctc  gtgtgcttc  tgctcatct  gtaccagta  gcgggccca  gactgagcc  240
gggcgcgcc  ggcggccgc  cgccgcccg  cgacctgga  ctgttcccc  cgcccgacc  300
ccactacga  aagaagtac  acttcccgg  ccgcgagct  gagcgctcg  tgcgcttcg  360
catgaaggg  gacgacgtg  tcgtcttcc  gcacatcca  aagacgggc  gcaccacct  420
cggccgcca  ctcgtgcag  acgtacgcc  cgaggtgcc  tgcgactgc  ggcccggcc  480
gaagaagtg  acctgctac  ggcccaacc  ccgcgagac  tggctcttc  cccgcttct  540
caccggctg  agctgcggg  tgcacgccg  ctggaccga  ctcaccaac  gcgtgcccg  600
cgtgctgga  cgccgcgac  ccgccgcgc  gcgcacgcc  aggaagttc  actacatca  660
cctgctacg  gaccccgtg  cccgctacc  gagcgagtg  cggcatgtg  agaggggtg  720
cacgtggaa  acgtcgttg  atatgtgtg  tgggcgcac  cccacgcct  aggagctgc  780
gccctgcta  gagggcacg  actggtcgg  ctgcacgct  caggagttc  tggactgcc  840
gtacaacct  gccaacaac  gccaggtgc  catgctggc  gacctgagc  tggtgggct  900
ctacaacct  tccttcatc  ccgagggca  gcgggccca  ctgctgctc  agagcgcca  960
gaagaacct  cggggcatg  ccttcttcg  cctgaccga  ttccagcgc  agacgcagt  1020
cctgttcga  cggacgttc  acctcaagt  catccggcc  ttcatgcag  acaatagca  1080
gcgggcggg  ggcgtggag  tggatgaag  caccatccg  cgcatcgag  agctcaacg  1140
cctggacat  cagctgtac  actacgcca  ggacctctt  cagcagcgc  accagtaca  1200
gcggcagct  gagcgcagg  agcagcgcc  gaggagccg  gaggagcgt  tgctgcacc  1260
ggccaagga  gcactgccg  gggaggatg  cgacgagcc  ggccgcgtg  ccaccgagg  1320
ctacatgag  cacatcatt  agaagtggt  gtggcggtg  tggccacgg  gaggcctct  1380
ggggggtgt  ggggataaa  caggacaga  gacaggtcc  cccaagact  tcaagggat  1440
agcatccca  acctgctcc  cagaggtag  tgcgtcctg  aaaaaaaca  agcagggat  1500
tagtggggc  gggcaggga  gggggcttg  gaaatcaac  ggtgcagcc  agtgggtca  1560
aggaaagcg  gctcgaagg  tgccatggt  agggcaggg  ctccagagc  ggtgttgtg  1620
ctggagctg  tctcctggc  tccttggat  tatcgcaaa  actgaaggt  tgcgcaaga  1680
acgaggaca  cggaaagtg  acctgccag  ccgggagtg  gtccctcac  aactatgca  1740
acagcactc  ctcttagct  ctctgtccg  gctactagg  gtgagacca  cttctggca  1800
ctgccccag  tccaggcca  cccatagcc  ctcctcttc  ggctgcccc  aatgccccg  1860
ggcctgggg  gcccccagc  cacccatct  tagctccct  aaagtcagg  cccacccca  1920
ctgaggcag  gaagactcg  gtccagccc  caggaagcc  gctcccctc  ctggcccat  1980
gtcctgctt  atgctttgg  tcaggaggc  aaagctgat  ttcaggccc  acccactcc  2040
tacagtcct  agacc  2055



<210> 4980
<211> 401
<212> PRT
<213> Homo sapiens
<308> XP_017698
<400> 4980

Met Val Glu Arg Ala Ser Lys Phe Val Leu Val Val Ala Gly Ser Val 
  1               5                  10                  15
Cys Phe Met Leu Ile Leu Tyr Gln Tyr Ala Gly Pro Gly Leu Ser Leu 
             20                  25                  30
Gly Ala Pro Gly Gly Arg Ala Pro Pro Asp Asp Leu Asp Leu Phe Pro 
         35                  40                  45
Thr Pro Asp Pro His Tyr Glu Lys Lys Tyr Tyr Phe Pro Val Arg Glu 
     50                  55                  60
Leu Glu Arg Ser Leu Arg Phe Asp Met Lys Gly Asp Asp Val Ile Val 
 65                  70                  75                  80
Phe Leu His Ile Gln Lys Thr Gly Gly Thr Thr Phe Gly Arg His Leu 
                 85                  90                  95
Val Gln Asn Val Arg Leu Glu Val Pro Cys Asp Cys Arg Pro Gly Gln 
             100                105                110
Lys Lys Cys Thr Cys Tyr Arg Pro Asn Arg Arg Glu Thr Trp Leu Phe 
         115                120                125
Ser Arg Phe Ser Thr Gly Trp Ser Cys Gly Leu His Ala Asp Trp Thr 
     130                135                140
Glu Leu Thr Asn Cys Val Pro Gly Val Leu Asp Arg Arg Asp Ser Ala 
 145                150                155                160
Ala Leu Arg Thr Pro Arg Lys Phe Tyr Tyr Ile Thr Leu Leu Arg Asp 
                 165                170                175
Pro Val Ser Arg Tyr Leu Ser Glu Trp Arg His Val Gln Arg Gly Ala 
             180                185                190
Thr Trp Lys Thr Ser Leu His Met Cys Asp Gly Arg Thr Pro Thr Pro 
         195                200                205
Glu Glu Leu Pro Pro Cys Tyr Glu Gly Thr Asp Trp Ser Gly Cys Thr 
     210                215                220
Leu Gln Glu Phe Met Asp Cys Pro Tyr Asn Leu Ala Asn Asn Arg Gln 
 225                230                235                240
Val Arg Met Leu Ala Asp Leu Ser Leu Val Gly Cys Tyr Asn Leu Ser 
                 245                250                255
Phe Ile Pro Glu Gly Lys Arg Ala Gln Leu Leu Leu Glu Ser Ala Lys 
             260                265                270
Lys Asn Leu Arg Gly Met Ala Phe Phe Gly Leu Thr Glu Phe Gln Arg 
         275                280                285
Lys Thr Gln Tyr Leu Phe Glu Arg Thr Phe Asn Leu Lys Phe Ile Arg 
     290                295                300
Pro Phe Met Gln Tyr Asn Ser Thr Arg Ala Gly Gly Val Glu Val Asp 
 305                310                315                320
Glu Asp Thr Ile Arg Arg Ile Glu Glu Leu Asn Asp Leu Asp Met Gln 
                 325                330                335
Leu Tyr Asp Tyr Ala Lys Asp Leu Phe Gln Gln Arg Tyr Gln Tyr Lys 
             340                345                350
Arg Gln Leu Glu Arg Arg Glu Gln Arg Leu Arg Ser Arg Glu Glu Arg 
         355                360                365
Leu Leu His Arg Ala Lys Glu Ala Leu Pro Arg Glu Asp Ala Asp Glu 
     370                375                380
Pro Gly Arg Val Pro Thr Glu Asp Tyr Met Ser His Ile Ile Glu Lys 
 385                390                395                400
Trp 
                 405



<210> 4981
<211> 458
<212> DNA
<213> Rattus norvegicus
<308> AA859750
<400> 4981

ttttttttt  tttttctga  gtaaataga  acatgtaga  tcttccctc  atgtcaggc  60
gcacttcat  agccccagc  cagtaatgc  gggaaccct  gtgacccat  ggccaagaa  120
ctcccagaa  cattaaaaa  aaagttata  tccgctgcc  agtggatag  catttagct  180
tttgtccct  gttttttat  tattccata  ttatgtttg  gctttttct  gtgtgaaca  240
tagtgaggc  tatgttttt  tgtggcttt  gagaaaact  cagtcttca  agaactgtt  300
taattagtt  cttctcgga  aaagttatg  gttaatttg  ttcaaaata  ttaggcatt  360
tttgaatta  aaacttgtg  tgcagggat  tgtgaacga  acgttcaca  gtgaagatg  420
cttcactta  catctgtgt  aacagaata  gatgtgta  458



<210> 4982
<211> 357
<212> DNA
<213> Homo sapiens
<308> AI671553
<400> 4982

ttttttttt  ttttactta  aagcatttt  ttatttaat  tctgaggga  aatactttt  60
tctttcaac  tccataaca  aatacagag  tatcagata  ccctggaaa  aatatgtat  120
ttatacata  atttctata  cattacatc  tatatatat  atatatatg  aaaaatttg  180
agactttat  gaaagcgga  catctaaaa  gcactgcac  atggagtta  gattactta  240
attttatgt  catatacac  ctttactct  ctcaagcag  taactagtg  agtcacctt  300
cacatgtaa  tgtctcatt  acaaatccc  gcatcacaa  tctataact  aaagaat  357



<210> 4983
<211> 497
<212> DNA
<213> Rattus norvegicus
<308> AA859783
<400> 4983

ttttttttt  tttttttac  agtaacaat  acttttatt  tctagcagg  catttttct  60
ctgcttcag  attttcctc  aagaaaaca  aagttttag  actggatca  ttgaccctt  120
ctcttcttg  cgcctccca  ttcaaaatg  ttgcatctc  taatggcca  catcctctt  180
gatctgcag  tgggctcaa  acactcaag  ctgagcaca  tcttctttg  ggttttggc  240
ttctttcga  aaattggct  tgtttgccc  ccatagcca  tctgcttcc  gtcgtagcg  300
cgctttcct  gggcataca  ggaatcctt  cccttctta  actgggtca  tttgtgagg  360
tggtgcttg  cacatttct  acagaaagt  cttcgggtt  taggtacgt  gaccatctt  420
gcagcagaa  tgtctgcga  gaaaacgag  gaccggcag  agcgatccc  cctcaaccg  480
cacctcgtg  cgaattc  497



<210> 4984
<211> 105
<212> PRT
<213> Rattus norvegicus
<308> P09896
<400> 4984

Val Asn Val Pro Lys Thr Arg Arg Thr Phe Cys Lys Lys Cys Gly Lys 
  1               5                  10                  15
His Gln Pro His Lys Val Thr Gln Tyr Lys Lys Gly Lys Asp Ser Leu 
             20                  25                  30
Tyr Ala Gln Gly Lys Arg Arg Tyr Asp Arg Lys Gln Ser Gly Tyr Gly 
         35                  40                  45
Gly Gln Thr Lys Pro Ile Phe Arg Lys Lys Ala Lys Thr Thr Lys Lys 
     50                  55                  60
Ile Val Leu Arg Leu Glu Cys Val Glu Pro Asn Cys Arg Ser Lys Arg 
 65                  70                  75                  80
Met Leu Ala Ile Lys Arg Cys Lys His Phe Glu Leu Gly Gly Asp Lys 
                 85                  90                  95
Lys Arg Lys Gly Gln Val Ile Gln Phe 
             100                105



<210> 4985
<211> 425
<212> DNA
<213> Homo sapiens
<308> NM_021029
<400> 4985

gcggtttct  tctttccgc  ccgatagcg  tcacgcaag  atggttaac  tccctaaaa  60
ccgccggac  ttctgtaag  agtgtggca  gcaccaacc  cataaagtg  cacagtaca  120
gaagggcaa  gattctctg  acgcccagg  aaagcggcg  tatgacagg  agcagagtg  180
ctatggtgg  caaactaag  cgattttcc  gaaaaaggc  aaaactaca  agaagattg  240
gctaaggct  gagtgcgtt  agcccaact  cagatctaa  agaatgctg  ctattaaaa  300
atgcaagca  tttgaactg  gaggagata  gaagagaaa  ggccaagtg  tccagttct  360
agtgtcatc  tttattatg  agacaataa  atcttgagt  tatgttcaa  aaaaaaaaa  420
aaaaa  425



<210> 4986
<211> 106
<212> PRT
<213> Homo sapiens
<308> NP_066357
<400> 4986

Met Val Asn Val Pro Lys Thr Arg Arg Thr Phe Cys Lys Lys Cys Gly 
  1               5                  10                  15
Lys His Gln Pro His Lys Val Thr Gln Tyr Lys Lys Gly Lys Asp Ser 
             20                  25                  30
Leu Tyr Ala Gln Gly Lys Arg Arg Tyr Asp Arg Lys Gln Ser Gly Tyr 
         35                  40                  45
Gly Gly Gln Thr Lys Pro Ile Phe Arg Lys Lys Ala Lys Thr Thr Lys 
     50                  55                  60
Lys Ile Val Leu Arg Leu Glu Cys Val Glu Pro Asn Cys Arg Ser Lys 
 65                  70                  75                  80
Arg Met Leu Ala Ile Lys Arg Cys Lys His Phe Glu Leu Gly Gly Asp 
                 85                  90                  95
Lys Lys Arg Lys Gly Gln Val Ile Gln Phe 
             100                105



<210> 4987
<211> 440
<212> DNA
<213> Rattus norvegicus
<308> AA859788
<400> 4987

ttttttttt  tttttttac  gagaacagt  ctttatttt  agagcagag  ctggagctg  60
ccacagtgg  cagcagttc  cactccctc  tgtccaaga  gccagcctc  gcacctcca  120
cttctgtgc  aggagagga  tgttctccc  aggaaggct  gagaacagc  cgctccagc  180
gcctccaca  tgggctttc  gtaggatcc  cctgagtca  gactttagg  caggttcag  240
tccaggttt  cttgctatc  cagtcttcg  gccttccgg  gtcggcagc  attgtgtgg  300
acaggggtg  tgtctgtga  ggagatcac  tccagacca  ccatggtca  tcctttgat  360
gcagaccag  gtcctggtc  aatgccttt  actacgact  tgatgtggg  cactccttt  420
cctgtggct  tctggagaga  440



<210> 4988
<211> 191
<212> PRT
<213> Rattus norvegicus
<308> BAB40998
<400> 4988

Met Gln Val Leu Arg Asn Ser Gly Ser Trp Leu Leu Arg Ser Trp Thr 
  1               5                  10                  15
Gly His Gly Met Thr Arg Phe Val Gly Ile Ala Pro Ala Lys Asn Ile 
             20                  25                  30
His Thr Gly Ala Pro Arg Leu Glu Asp Ser Ala Ala Arg Gln Asn Thr 
         35                  40                  45
Glu Arg Glu Ala Ala Pro Ser Arg Phe Ser Leu Tyr Pro Pro Val Pro 
     50                  55                  60
Gly Gln Glu Ser Ser Leu Gln Trp Ala Gly Met Lys Phe Glu Asp Val 
 65                  70                  75                  80
Pro Ile Ala His Ile Lys Ala Thr Tyr Asn Asn Thr Gln Ile Gln Val 
                 85                  90                  95
Val Ser Ala Thr Asn Ala Ser Leu Ala Arg Ala Ser Cys Gly Thr Glu 
             100                105                110
Gly Phe Arg Asn Ala Lys Lys Gly Thr Gly Ile Ala Ala Gln Thr Ala 
         115                120                125
Gly Ile Ala Ala Ala Ala Lys Ala Thr Gly Lys Gly Val Thr His Ile 
     130                135                140
Arg Val Val Val Lys Gly Met Gly Pro Gly Arg Trp Ser Ala Ile Lys 
 145                150                155                160
Gly Leu Thr Met Gly Gly Leu Glu Val Ile Ser Ile Thr Asp Asn Thr 
                 165                170                175
Pro Val Pro His Asn Gly Cys Arg Pro Arg Lys Ala Arg Arg Leu 
             180                185                190



<210> 4989
<211> 894
<212> DNA
<213> Homo sapiens
<308> AK026165
<400> 4989

aattcaagt  atgcaggct  tgagaaacg  ggggtcgcg  ttcctgcgg  cctggactt  60
gccccagac  gccggcagg  tcgtggcca  aacgccggc  gggaccatc  gcacaggcg  120
tcgacagct  caagacgct  cggccaagc  gaaagttga  cagtacgcg  ctcccagcc  180
caccaagtt  agcatttac  ctcccattc  aggagagga  agctctctg  ggtgggcag  240
aaagaaatt  gaggagatc  caattgcac  cattaaagc  tcccacaac  acacacaga  300
ccaggtagt  tctgctagt  atgagcccc  tgcctttgc  tcctgtggc  cagagggat  360
tcggaatgc  aagaagggc  caggcatcg  agcacagac  gcaggcata  ccgcagcgg  420
gagagctaa  caaaagggc  tgatccaca  ccgagttgt  gtgaaaggc  tggggccag  480
acgcttgtc  gccatgcac  gactgatca  gggcggcct  gaagtgatc  caatcacag  540
caacacccc  atcccacac  acggctgcc  ccccaggaa  gctcggaag  tgtgatggg  600
aggaggcct  cacttggac  tgacctcaa  cctcagctc  agtgggacc  tgtaaaatg  660
tccctgtca  agctctcca  aatatgctt  ttggagatc  ttcaggcag  aagggagag  720
tttgcctcc  tacacagtg  cctttgctt  cacctccag  tggagatgg  tgtgcccca  780
aagtaagct  tgcatctct  acaagaggg  agctacagg  gcagccgtg  cctaggccc  840
aactctgct  tgagaaaat  aatatctgt  ccacctgtc  aaaaaaaaa  aaaa  894



<210> 4990
<211> 194
<212> PRT
<213> Homo sapiens
<308> P82912
<400> 4990

Met Gln Ala Val Arg Asn Ala Gly Ser Arg Phe Leu Arg Ser Trp Thr 
  1               5                  10                  15
Trp Pro Gln Thr Ala Gly Arg Val Val Ala Arg Thr Pro Ala Gly Thr 
             20                  25                  30
Ile Cys Thr Gly Ala Arg Gln Leu Gln Asp Ala Ala Ala Lys Gln Lys 
         35                  40                  45
Val Glu Gln Asn Ala Ala Pro Ser His Thr Lys Phe Ser Ile Tyr Pro 
     50                  55                  60
Pro Ile Pro Gly Glu Glu Ser Ser Leu Arg Trp Ala Gly Lys Lys Phe 
 65                  70                  75                  80
Glu Glu Ile Pro Ile Ala His Ile Lys Ala Ser His Asn Asn Thr Gln 
                 85                  90                  95
Ile Gln Val Val Ser Ala Ser Asn Glu Pro Leu Ala Phe Ala Ser Cys 
             100                105                110
Gly Thr Glu Gly Phe Arg Asn Ala Lys Lys Gly Thr Gly Ile Ala Ala 
         115                120                125
Gln Thr Ala Gly Ile Ala Ala Ala Ala Arg Ala Lys Gln Lys Gly Val 
     130                135                140
Ile His Ile Arg Val Val Val Lys Gly Leu Gly Pro Gly Arg Leu Ser 
 145                150                155                160
Ala Met His Gly Leu Ile Met Gly Gly Leu Glu Val Ile Ser Ile Thr 
                 165                170                175
Asp Asn Thr Pro Ile Pro His Asn Gly Cys Arg Pro Arg Lys Ala Arg 
             180                185                190
Lys Leu 
         195



<210> 4991
<211> 450
<212> DNA
<213> Rattus norvegicus
<308> AA859805
<400> 4991

ttttttttt  tttttttga  tagaaaacc  ttgttttat  aagcacccg  gcaatcttg  60
tgtgtggga  ggccaaaac  tcaaaatta  aaccaacaa  agacaaaat  gtgttgtag  120
ggagactta  gtacaaaac  gggtctggc  tccagaatc  ctgtgggtt  ggtccatgt  180
cactccctg  ggccggcag  gagggatgc  ccagcggcc  gctgccctc  ccctccggc  240
aggcggcta  gcttcttgg  ggaggctgc  tggaagcag  tcctgcttt  caaggggag  300
caagggggg  tccgtccac  gagatcagg  ctggacgat  ttgcagttt  ttgtagaga  360
gaagcgacc  gtgtagtgg  tgttgcatc  caccacgtt  ttggtgaag  cagactcca  420
aacaatgta  ttggggttc  cgtgcacctt  450



<210> 4992
<211> 2328
<212> DNA
<213> Homo sapiens
<308> L21186
<400> 4992

gccagccga  cggccagcc  gtgcggggc  ggccatgta  ggcccacag  cggtcctgc  60
cgcccggtg  cctgcggag  gcctcgtgc  gccctgggc  ccgcccctg  cctgccctg  120
ccccttggc  ttgaaatgc  gtcatcgga  gagccgtcc  gctcgggac  aggccagca  180
ggacaaagc  agagctggg  caagcaagg  gccttcctg  cctcgaggc  gtgggaaga  240
aagcacgcc  agggggcca  tcctgagag  ctctctgtc  accaggcct  tgcagaggg  300
tcaccatgg  tctggcccg  ggcagccgg  agctggggg  cctggtgtg  ggcgcctgc  360
tgtgcgtgc  ggtgcacgg  cagcaggcg  agcccgggc  gggctcgga  cccgcccgc  420
ggcggcagc  gatccagtg  gagaacaac  ggcaggtgt  cagcttgct  aactcgggc  480
cagagtacg  gccggccgg  cctcagcgc  ccgagagta  ctcccgggt  ctgctggcc  540
gcgcgcccc  ggcccagca  cggcgcagc  acgggagcc  ccggcgtcg  caggcgccg  600
ccctgcccc  gccggggcg  gtgggctcg  acaccgtgc  cggccaggc  cggcaccca  660
tcggctttg  ccaggtgcc  gacaactgg  gcgaggtgg  cgtcgggga  agcacgggc  720
tggccctgg  ccgcacctc  gtctcccag  aacggcacg  gggctccgc  tcctcggtc  780
cggcttcgg  cttcgccag  acctaccgc  agcagccct  ctacccgca  cagttcccc  840
acccgcagg  gcccttcgt  agccagtac  agaactacg  ccccgcgtc  cggacctac  900
accagggtt  cgtgtacta  cggcccgcg  gcggcggcg  gggcgcggg  gcggcggcc  960
tggcctcgg  gggggtcat  tacccctac  agccccggg  gcgctacga  gagtacggc  1020
gcggcgaag  gctgcccga  tacccgcct  agggcttct  cccggcccc  gagaggccc  1080
acgtgccgc  gccgccgcc  ccccccgac  gcctggacc  ccgctactc  cacagtctg  1140
acagcgagg  cacccccgg  ttcgagcag  cctaccctg  ccccggtcc  gaggcggcg  1200
aggcccatg  cggagaccc  cgcctgggc  ggtacccgc  ctacgccaa  ccgccgccc  1260
aggcgtacg  gccgccgcg  gcgctggag  cgccctacc  gccggtgcg  agctccgac  1320
cgcccccgc  gggtgggga  cggaacggc  cgcagcagg  ccgcctcag  gtaggcagc  1380
tgtaccggc  caaccagaa  ggccgcggt  tccctgact  ggtcccaga  cccaactat  1440
tgcaagcat  cacttatgt  cagagagcc  acctgtact  cctgcgctg  gctgcggag  1500
agaagtgtc  ggccagcac  gcctatgcc  ctgaggcca  cgactacga  gtgcgggtg  1560
tactgcgct  cccccagcg  gtgaagaac  agggcacag  agacttcct  cccaaccgg  1620
cacggcaca  ctgggagtg  cacagctgc  accagcatt  ccacagcat  gacgagttc  1680
gccactacg  cctactgga  gcagccaca  gcaagaagg  ggccgaggg  cacaaggcc  1740
gtttctgcc  ggaggacag  acctgtgac  tcggcaacc  caagcgcta  gcatgcacc  1800
ctcataccc  gggcctgag  ccaggctgc  atgacacct  caatgcgga  atcgactgc  1860
agtggatcg  cataaccga  gtgcagcct  ggaactaca  cctcaaggt  cacgtgaac  1920
caaagtata  tgttttgga  tctgacttc  ccaacaacg  ggtgagatg  aacattcac  1980
acacaggtc  ctacgtttc  gcaacaaac  gcaaaattg  ccaatcctg  tctccggga  2040
ggacagatg  ccaatctct  cccttccaa  gcaggccct  ctccccggg  agcctcccg  2100
cgaggggcc  agcccccaa  ccacaggca  ggaggggca  ccctccctg  cggcctcag  2160
gagcgaacg  ggatgaaaa  cacagggat  ccggatgcc  gaccccatt  tatacttca  2220
ttttctcta  agtgttgtt  tgttgttgt  ggtttttat  ttttatact  tggccatac  2280
acagagcta  attgcccag  tctgggctg  ataaaacaa  gtttttct  2328



<210> 4993
<211> 574
<212> PRT
<213> Homo sapiens
<308> Q08397
<400> 4993

Met Ala Leu Ala Arg Gly Ser Arg Gln Leu Gly Ala Leu Val Trp Gly 
  1               5                  10                  15
Ala Cys Leu Cys Val Leu Val His Gly Gln Gln Ala Gln Pro Gly Gln 
             20                  25                  30
Gly Ser Asp Pro Ala Arg Trp Arg Gln Leu Ile Gln Trp Glu Asn Asn 
         35                  40                  45
Gly Gln Val Tyr Ser Leu Leu Asn Ser Gly Ser Glu Tyr Val Pro Ala 
     50                  55                  60
Gly Pro Gln Arg Ser Glu Ser Ser Ser Arg Val Leu Leu Ala Gly Ala 
 65                  70                  75                  80
Pro Gln Ala Gln Gln Arg Arg Ser His Gly Ser Pro Arg Arg Arg Gln 
                 85                  90                  95
Ala Pro Ser Leu Pro Leu Pro Gly Arg Val Gly Ser Asp Thr Val Arg 
             100                105                110
Gly Gln Ala Arg His Pro Phe Gly Phe Gly Gln Val Pro Asp Asn Trp 
         115                120                125
Arg Glu Val Ala Val Gly Asp Ser Thr Gly Met Ala Leu Ala Arg Thr 
     130                135                140
Ser Val Ser Gln Gln Arg His Gly Gly Ser Ala Ser Ser Val Ser Ala 
 145                150                155                160
Ser Ala Phe Ala Ser Thr Tyr Arg Gln Gln Pro Ser Tyr Pro Gln Gln 
                 165                170                175
Phe Pro Tyr Pro Gln Ala Pro Phe Val Ser Gln Tyr Glu Asn Tyr Asp 
             180                185                190
Pro Ala Ser Arg Thr Tyr Asp Gln Gly Phe Val Tyr Tyr Arg Pro Ala 
         195                200                205
Gly Gly Gly Val Gly Ala Gly Ala Ala Ala Val Ala Ser Ala Gly Val 
     210                215                220
Ile Tyr Pro Tyr Gln Pro Arg Ala Arg Tyr Glu Glu Tyr Gly Gly Gly 
 225                230                235                240
Glu Glu Leu Pro Glu Tyr Pro Pro Gln Gly Phe Tyr Pro Ala Pro Glu 
                 245                250                255
Arg Pro Tyr Val Pro Pro Pro Pro Pro Pro Pro Asp Gly Leu Asp Arg 
             260                265                270
Arg Tyr Ser His Ser Leu Tyr Ser Glu Gly Thr Pro Gly Phe Glu Gln 
         275                280                285
Ala Tyr Pro Asp Pro Gly Pro Glu Ala Ala Gln Ala His Gly Gly Asp 
     290                295                300
Pro Arg Leu Gly Trp Tyr Pro Pro Tyr Ala Asn Pro Pro Pro Glu Ala 
 305                310                315                320
Tyr Gly Pro Pro Arg Ala Leu Glu Pro Pro Tyr Leu Pro Val Arg Ser 
                 325                330                335
Ser Asp Thr Pro Pro Pro Gly Gly Glu Arg Asn Gly Ala Gln Gln Gly 
             340                345                350
Arg Leu Ser Val Gly Ser Val Tyr Arg Pro Asn Gln Asn Gly Arg Gly 
         355                360                365
Leu Pro Asp Leu Val Pro Asp Pro Asn Tyr Val Gln Ala Ser Thr Tyr 
     370                375                380
Val Gln Arg Ala His Leu Tyr Ser Leu Arg Cys Ala Ala Glu Glu Lys 
 385                390                395                400
Cys Leu Ala Ser Thr Ala Tyr Ala Pro Glu Ala Thr Asp Tyr Asp Val 
                 405                410                415
Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln Gly Thr Ala 
             420                425                430
Asp Phe Leu Pro Asn Arg Pro Arg His Thr Trp Glu Trp His Ser Cys 
         435                440                445
His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr Asp Leu Leu 
     450                455                460
Asp Ala Ala Thr Gly Lys Lys Val Ala Glu Gly His Lys Ala Ser Phe 
 465                470                475                480
Cys Leu Glu Asp Ser Thr Cys Asp Phe Gly Asn Leu Lys Arg Tyr Ala 
                 485                490                495
Cys Thr Ser His Thr Gln Gly Leu Ser Pro Gly Cys Tyr Asp Thr Tyr 
             500                505                510
Asn Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp Val Gln Pro 
         515                520                525
Gly Asn Tyr Ile Leu Lys Val His Val Asn Pro Lys Tyr Ile Val Leu 
     530                535                540
Glu Ser Asp Phe Thr Asn Asn Val Val Arg Cys Asn Ile His Tyr Thr 
 545                550                555                560
Gly Arg Tyr Val Ser Ala Thr Asn Cys Lys Ile Val Gln Ser 
                 565                570



<210> 4994
<211> 517
<212> DNA
<213> Rattus norvegicus
<308> AA859827
<400> 4994

ttttttttt  tttttttat  tatatgtat  tatgtgtgt  tttataact  gttacacgt  60
ggattcata  ttaggcatc  ccagtacta  ttggcacag  ttgtcactt  agctcaggg  120
caagttcgg  caagatttg  tgttccaaa  tacaaaagg  cagaaagga  aatcaaggc  180
tttcatctc  gtggtgttt  cttaaatac  gtaatttca  aggaggcat  tgtacaggt  240
accaaagcc  ctcgacccc  cctgcgtct  ggagctggg  gctggggta  ggagtcagg  300
cacgggggg  tcaatgtgg  cggctgctg  actctgacg  ctgcctctt  cgggaaggg  360
tatagccgt  gagatagcc  ttcgtctgc  gcttggaga  cccgccgtt  aggatgtcc  420
gtatatgct  cacgatgag  ttgatggcc  cgagattgt  tgcacctct  ggaatgatc  480
catcagcat  tttctttgt  ggcaagcag  actcctc  517



<210> 4995
<211> 105
<212> PRT
<213> Rattus norvegicus
<308> BAA83085
<400> 4995

Lys Leu Phe Val Asp Thr Asp Ala Asp Thr Arg Leu Ser Arg Arg Val 
  1               5                  10                  15
Leu Arg Asp Ile Ser Glu Arg Gly Arg Asp Leu Glu Gln Ile Leu Ser 
             20                  25                  30
Gln Tyr Ile Thr Phe Val Lys Pro Ala Phe Glu Glu Phe Cys Leu Pro 
         35                  40                  45
Thr Lys Lys Tyr Ala Asp Val Ile Ile Pro Arg Gly Ala Asp Asn Leu 
     50                  55                  60
Val Ala Ile Asn Leu Ile Val Gln His Ile Gln Asp Ile Leu Asn Gly 
 65                  70                  75                  80
Gly Leu Ser Lys Arg Gln Thr Asn Gly Tyr Leu Asn Gly Tyr Thr Pro 
                 85                  90                  95
Ser Arg Lys Arg Gln Ala Ser Glu Ser 
             100                105



<210> 4996
<211> 437
<212> DNA
<213> Homo sapiens
<308> BF745219
<400> 4996

gctgccggt  gctctagca  gatcccctt  aatggccgg  ggcgttgaa  ggcccggag  60
cgttgaatg  cccggaggc  ttgaatggc  cggaggcgt  gaatggccc  gaggcgttg  120
atggcccgg  ggcgttgaa  ggcccggag  cgttgaatg  cccggaggg  cctccattc  180
ggatgtcct  gatgtgctg  acgatgagg  tgatggcca  cagattatc  gcacctcta  240
ggatgatca  atcagcata  ttctttgtt  gcaagcaga  ttcctcaaa  tcagtgaca  300
gccaggtag  aaagcatga  aggatgctc  ggtagggac  tgcccagac  caggcaggg  360
gctggagtg  acacaggag  tgaggctga  tgcggagtc  cacagacaa  ccttgtttg  420
aggaaggaa  ctgcaag  437



<210> 4997
<211> 84
<212> PRT
<213> Homo sapiens
<308> P04155
<400> 4997

Met Ala Thr Met Glu Asn Lys Val Ile Cys Ala Leu Val Leu Val Ser 
  1               5                  10                  15
Met Leu Ala Leu Gly Thr Leu Ala Glu Ala Gln Thr Glu Thr Cys Thr 
             20                  25                  30
Val Ala Pro Arg Glu Arg Gln Asn Cys Gly Phe Pro Gly Val Thr Pro 
         35                  40                  45
Ser Gln Cys Ala Asn Lys Gly Cys Cys Phe Asp Asp Thr Val Arg Gly 
     50                  55                  60
Val Pro Trp Cys Phe Tyr Pro Asn Thr Ile Asp Val Pro Pro Glu Glu 
 65                  70                  75                  80
Glu Cys Glu Phe 
                 85



<210> 4998
<211> 575
<212> DNA
<213> Rattus norvegicus
<308> AA859832
<400> 4998

ttttttttt  tttttttac  ggccacttc  aagaatgct  tacaggttg  gcaaaaaca  60
ttacaggct  catgtggta  ttgtttgtt  gttttttta  acaagtttt  ccaactaca  120
ctacaacag  catctgata  aacactaaa  aactcttct  aggaaaaca  aaccaggga  180
tcctcttaa  accataatc  acaacccat  cctgcccca  taacatttc  tttcataat  240
aaaacacaa  acagaaaca  aatgcagac  tccactttg  tacaggaga  ctcctgaac  300
aacccaaca  ggatgtggc  gtttcattc  ccattcaac  agaaaaaca  ctttttaaa  360
agaggactt  gacttttct  gtgttgtaa  ccaacagcg  gtatactct  taacccctg  420
tgccccaaa  ttcagtgtt  agtttttgc  cttcttatg  ctccatcac  tagaatcca  480
gtcacagac  ctgtaagtg  tacttgttg  aggactaac  tctgaaggg  cagcttctg  540
ctcaggaaa  taagtttcc  attaaaaca  aattt  575



<210> 4999
<211> 479
<212> DNA
<213> Homo sapiens
<308> AI139056
<400> 4999

ttttttttt  ttttttgaa  tcaatccaa  tggttattt  ttctaaaac  ggaagctac  60
ttgcctaca  tttcgccag  atggtgtaa  gagaacagg  gaggaaaaa  ttacagatg  120
aaacaatga  acagttaca  ttttttttt  aatggtaaa  ccccttttt  ctggccact  180
ccaagaatg  tttacaggt  gtgcaaaaa  atttacagg  tccatgtgg  gtttttctc  240
caagctttc  tgtctacaa  tacaacaga  gtctgataa  acactaaac  agtcttcta  300
ggaaaacaa  gctagggat  cctctggtt  ccataatcc  cattttccc  cttaacata  360
tttttcata  taaaaagac  gaaacaaaa  ccggacatc  actgttgtt  caaatgatc  420
cttggacta  accaacaag  atgtggcag  ttcactttc  acccaccta  aaaaacagt  479



<210> 5000
<211> 503
<212> DNA
<213> Rattus norvegicus
<308> AA859837
<400> 5000

ttttttttt  tttttttga  tatactttc  gatcggtcc  tgggtacaa  gaagatagc  60
gactcatgt  ctcccagga  agcgtcatg  atgtccaag  gccttacac  gagctggag  120
atggaacga  ctgctttcc  cccacataa  cctcctcaa  gtttcggtc  tctcctaga  180
agaggaact  ctggataac  gcctcagaa  tatcaccaa  gaaatcccc  caaaacaga  240
caatgggag  gtccgatgc  ctggggttg  tcaagaggg  atcaaaatc  ttgccgacc  300
caaagtttc  aatttcacg  tcaagcccc  gggcttggc  tcctccaag  gtggctagt  360
tgaagactt  tttgagggt  aggcttttc  cattcacct  attaattaa  aggacgttg  420
aaaccatca  tgctcttcg  atggcgtca  gcatggaat  ggagtaacc  ccagccaca  480
ctgtcccaa  ccctatctt  act  503



<210> 5001
<211> 71
<212> PRT
<213> Rattus norvegicus
<308> P36577
<400> 5001

Leu Lys His Glu Asp Thr Asn Leu Ser Val Ser Leu Thr Asp Ser Ser 
  1               5                  10                  15
Val Val Ser Leu Tyr Ser Gly Thr Val Leu Phe Lys Ser Met His Thr 
             20                  25                  30
Leu Pro Thr Asn Ala Arg Cys Pro Asn Leu Ser Val Ile Ser Ala Thr 
         35                  40                  45
Ser Gly Met Ser Gln Cys Glu Leu Ser Gln Ser Ser Met Pro Trp Trp 
     50                  55                  60
Cys Arg Ser Leu Val Phe Ser 
 65                  70



<210> 5002
<211> 1630
<212> DNA
<213> Homo sapiens
<308> NM_004293
<400> 5002

cggcagccg  ccgcagctg  agagagtcc  gctgcgtct  cgccgcgtg  gccctcctc  60
accagcaga  ccgcgctgc  ctccgccgc  gacatgtgt  ccgctcaga  gccgcccct  120
gcgcacatc  tccgaggga  gttcgtcca  tccacctgg  cctgcccca  ggaggtgct  180
cgggatcac  tcctcggcg  gagcgacag  ggcaaaata  tgtttttag  agaagcatc  240
caacaggaa  aactggcca  agaatggtg  ttcaagccg  gtgaaataa  agaactgag  300
caccatgag  tcttcatgc  tgggctggt  gatacacac  tccatgcct  tcagtattc  360
tttgctgga  gtagcatag  cctgccact  ttggagtgg  tgaccaagt  cacatttcc  420
gcagaacac  gattccaga  catcgactt  gcagaagaa  tatatacca  agttgtcag  480
agaacacta  agaatggaa  aaccacagc  tgttacttt  caacaattc  cactgactc  540
tctctgctc  ttgccgaca  tacagataa  tttggacag  gggcatttg  gggcaaagt  600
tgcatggat  tgaatgaca  ttttccaga  tacaaggag  ccactgagg  atcgatcaa  660
gaaactgag  gatttgtgt  agaaatgct  caaaagaac  attctagag  gaagcccat  720
gtgacacca  gtttttccc  ctcctgctc  gagactttg  tgggtgaac  gggcaacat  780
gctaaaacc  gtgatttgc  cattcagag  catataagt  aaaatcgtg  tgaagttga  840
gctgtgaaa  acttatacc  cagttataa  aactacaca  ctgtgtatg  taaaaacaa  900
cttttgaca  ataagacag  gatggcaca  ggctgctac  tctctgcag  agaactgaa  960
gtattccat  aacgaggag  atccatcgc  cactgtccc  attctaatt  atcgctcag  1020
agtggattt  taaatgtgc  agaagtcct  aaacatgaa  tcaagatag  gctgggtac  1080
gacgtggct  gtggctatt  atattccat  cttgatgca  tcagaagag  agtgatggt  1140
tccaatatc  ttttaatta  taaggtaaa  gagaaaagc  tcaccctca  agaagtctt  1200
agactagct  ctcttggag  aagccaagc  ctggggctg  atggtgaga  tggaaactt  1260
gaagtgggc  aggaatttg  tgccatcct  atcaacccc  aagcatccg  ctctcccat  1320
gacctgttt  atggggact  ttttggtga  atttctgag  ctgttatcc  gaagttcct  1380
tatctagga  atgatcgaa  tattgaaga  gtttatgtg  gcggaaagc  ggtggttcc  1440
ttttccagc  cagtgtaag  ccctcgggc  tctacaaag  tctcctggg  ttagcgtgg  1500
tctgcatct  ccttgtgcc  aggtggagt  agaaagtca  aaaatagta  cttgttctt  1560
ggatgacta  ccctttctg  gtctagtta  agtattcac  tgacaaata  ttcgaagga  1620
gttgcactaa  1630



<210> 5003
<211> 454
<212> PRT
<213> Homo sapiens
<308> Q9Y2T3
<400> 5003

Met Cys Ala Ala Gln Met Pro Pro Leu Ala His Ile Phe Arg Gly Thr 
  1               5                  10                  15
Phe Val His Ser Thr Trp Thr Cys Pro Met Glu Val Leu Arg Asp His 
             20                  25                  30
Leu Leu Gly Val Ser Asp Ser Gly Lys Ile Val Phe Leu Glu Glu Ala 
         35                  40                  45
Ser Gln Gln Glu Lys Leu Ala Lys Glu Trp Cys Phe Lys Pro Cys Glu 
     50                  55                  60
Ile Arg Glu Leu Ser His His Glu Phe Phe Met Pro Gly Leu Val Asp 
 65                  70                  75                  80
Thr His Ile His Ala Ser Gln Tyr Ser Phe Ala Gly Ser Ser Ile Asp 
                 85                  90                  95
Leu Pro Leu Leu Glu Trp Leu Thr Lys Tyr Thr Phe Pro Ala Glu His 
             100                105                110
Arg Phe Gln Asn Ile Asp Phe Ala Glu Glu Val Tyr Thr Arg Val Val 
         115                120                125
Arg Arg Thr Leu Lys Asn Gly Thr Thr Thr Ala Cys Tyr Phe Ala Thr 
     130                135                140
Ile His Thr Asp Ser Ser Leu Leu Leu Ala Asp Ile Thr Asp Lys Phe 
 145                150                155                160
Gly Gln Arg Ala Phe Val Gly Lys Val Cys Met Asp Leu Asn Asp Thr 
                 165                170                175
Phe Pro Glu Tyr Lys Glu Thr Thr Glu Glu Ser Ile Lys Glu Thr Glu 
             180                185                190
Arg Phe Val Ser Glu Met Leu Gln Lys Asn Tyr Ser Arg Val Lys Pro 
         195                200                205
Ile Val Thr Pro Arg Phe Ser Leu Ser Cys Ser Glu Thr Leu Met Gly 
     210                215                220
Glu Leu Gly Asn Ile Ala Lys Thr Arg Asp Leu His Ile Gln Ser His 
 225                230                235                240
Ile Ser Glu Asn Arg Asp Glu Val Glu Ala Val Lys Asn Leu Tyr Pro 
                 245                250                255
Ser Tyr Lys Asn Tyr Thr Ser Val Tyr Asp Lys Asn Asn Leu Leu Thr 
             260                265                270
Asn Lys Thr Val Met Ala His Gly Cys Tyr Leu Ser Ala Glu Glu Leu 
         275                280                285
Asn Val Phe His Glu Arg Gly Ala Ser Ile Ala His Cys Pro Asn Ser 
     290                295                300
Asn Leu Ser Leu Ser Ser Gly Phe Leu Asn Val Leu Glu Val Leu Lys 
 305                310                315                320
His Glu Val Lys Ile Gly Leu Gly Thr Asp Val Ala Gly Gly Tyr Ser 
                 325                330                335
Tyr Ser Met Leu Asp Ala Ile Arg Arg Ala Val Met Val Ser Asn Ile 
             340                345                350
Leu Leu Ile Asn Lys Val Asn Glu Lys Ser Leu Thr Leu Lys Glu Val 
         355                360                365
Phe Arg Leu Ala Thr Leu Gly Gly Ser Gln Ala Leu Gly Leu Asp Gly 
     370                375                380
Glu Ile Gly Asn Phe Glu Val Gly Lys Glu Phe Asp Ala Ile Leu Ile 
 385                390                395                400
Asn Pro Lys Ala Ser Asp Ser Pro Ile Asp Leu Phe Tyr Gly Asp Phe 
                 405                410                415
Phe Gly Asp Ile Ser Glu Ala Val Ile Gln Lys Phe Leu Tyr Leu Gly 
             420                425                430
Asp Asp Arg Asn Ile Glu Glu Val Tyr Val Gly Gly Lys Gln Val Val 
         435                440                445
Pro Phe Ser Ser Ser Val 
     450



<210> 5004
<211> 503
<212> DNA
<213> Rattus norvegicus
<308> AA859837
<400> 5004

ttttttttt  tttttttga  tatactttc  gatcggtcc  tgggtacaa  gaagatagc  60
gactcatgt  ctcccagga  agcgtcatg  atgtccaag  gccttacac  gagctggag  120
atggaacga  ctgctttcc  cccacataa  cctcctcaa  gtttcggtc  tctcctaga  180
agaggaact  ctggataac  gcctcagaa  tatcaccaa  gaaatcccc  caaaacaga  240
caatgggag  gtccgatgc  ctggggttg  tcaagaggg  atcaaaatc  ttgccgacc  300
caaagtttc  aatttcacg  tcaagcccc  gggcttggc  tcctccaag  gtggctagt  360
tgaagactt  tttgagggt  aggcttttc  cattcacct  attaattaa  aggacgttg  420
aaaccatca  tgctcttcg  atggcgtca  gcatggaat  ggagtaacc  ccagccaca  480
ctgtcccaa  ccctatctt  act  503



<210> 5005
<211> 71
<212> PRT
<213> Rattus norvegicus
<308> P36577
<400> 5005

Leu Lys His Glu Asp Thr Asn Leu Ser Val Ser Leu Thr Asp Ser Ser 
  1               5                  10                  15
Val Val Ser Leu Tyr Ser Gly Thr Val Leu Phe Lys Ser Met His Thr 
             20                  25                  30
Leu Pro Thr Asn Ala Arg Cys Pro Asn Leu Ser Val Ile Ser Ala Thr 
         35                  40                  45
Ser Gly Met Ser Gln Cys Glu Leu Ser Gln Ser Ser Met Pro Trp Trp 
     50                  55                  60
Cys Arg Ser Leu Val Phe Ser 
 65                  70



<210> 5006
<211> 1630
<212> DNA
<213> Homo sapiens
<308> NM_004293
<400> 5006

cggcagccg  ccgcagctg  agagagtcc  gctgcgtct  cgccgcgtg  gccctcctc  60
accagcaga  ccgcgctgc  ctccgccgc  gacatgtgt  ccgctcaga  gccgcccct  120
gcgcacatc  tccgaggga  gttcgtcca  tccacctgg  cctgcccca  ggaggtgct  180
cgggatcac  tcctcggcg  gagcgacag  ggcaaaata  tgtttttag  agaagcatc  240
caacaggaa  aactggcca  agaatggtg  ttcaagccg  gtgaaataa  agaactgag  300
caccatgag  tcttcatgc  tgggctggt  gatacacac  tccatgcct  tcagtattc  360
tttgctgga  gtagcatag  cctgccact  ttggagtgg  tgaccaagt  cacatttcc  420
gcagaacac  gattccaga  catcgactt  gcagaagaa  tatatacca  agttgtcag  480
agaacacta  agaatggaa  aaccacagc  tgttacttt  caacaattc  cactgactc  540
tctctgctc  ttgccgaca  tacagataa  tttggacag  gggcatttg  gggcaaagt  600
tgcatggat  tgaatgaca  ttttccaga  tacaaggag  ccactgagg  atcgatcaa  660
gaaactgag  gatttgtgt  agaaatgct  caaaagaac  attctagag  gaagcccat  720
gtgacacca  gtttttccc  ctcctgctc  gagactttg  tgggtgaac  gggcaacat  780
gctaaaacc  gtgatttgc  cattcagag  catataagt  aaaatcgtg  tgaagttga  840
gctgtgaaa  acttatacc  cagttataa  aactacaca  ctgtgtatg  taaaaacaa  900
cttttgaca  ataagacag  gatggcaca  ggctgctac  tctctgcag  agaactgaa  960
gtattccat  aacgaggag  atccatcgc  cactgtccc  attctaatt  atcgctcag  1020
agtggattt  taaatgtgc  agaagtcct  aaacatgaa  tcaagatag  gctgggtac  1080
gacgtggct  gtggctatt  atattccat  cttgatgca  tcagaagag  agtgatggt  1140
tccaatatc  ttttaatta  taaggtaaa  gagaaaagc  tcaccctca  agaagtctt  1200
agactagct  ctcttggag  aagccaagc  ctggggctg  atggtgaga  tggaaactt  1260
gaagtgggc  aggaatttg  tgccatcct  atcaacccc  aagcatccg  ctctcccat  1320
gacctgttt  atggggact  ttttggtga  atttctgag  ctgttatcc  gaagttcct  1380
tatctagga  atgatcgaa  tattgaaga  gtttatgtg  gcggaaagc  ggtggttcc  1440
ttttccagc  cagtgtaag  ccctcgggc  tctacaaag  tctcctggg  ttagcgtgg  1500
tctgcatct  ccttgtgcc  aggtggagt  agaaagtca  aaaatagta  cttgttctt  1560
ggatgacta  ccctttctg  gtctagtta  agtattcac  tgacaaata  ttcgaagga  1620
gttgcactaa  1630



<210> 5007
<211> 454
<212> PRT
<213> Homo sapiens
<308> Q9Y2T3
<400> 5007

Met Cys Ala Ala Gln Met Pro Pro Leu Ala His Ile Phe Arg Gly Thr 
  1               5                  10                  15
Phe Val His Ser Thr Trp Thr Cys Pro Met Glu Val Leu Arg Asp His 
             20                  25                  30
Leu Leu Gly Val Ser Asp Ser Gly Lys Ile Val Phe Leu Glu Glu Ala 
         35                  40                  45
Ser Gln Gln Glu Lys Leu Ala Lys Glu Trp Cys Phe Lys Pro Cys Glu 
     50                  55                  60
Ile Arg Glu Leu Ser His His Glu Phe Phe Met Pro Gly Leu Val Asp 
 65                  70                  75                  80
Thr His Ile His Ala Ser Gln Tyr Ser Phe Ala Gly Ser Ser Ile Asp 
                 85                  90                  95
Leu Pro Leu Leu Glu Trp Leu Thr Lys Tyr Thr Phe Pro Ala Glu His 
             100                105                110
Arg Phe Gln Asn Ile Asp Phe Ala Glu Glu Val Tyr Thr Arg Val Val 
         115                120                125
Arg Arg Thr Leu Lys Asn Gly Thr Thr Thr Ala Cys Tyr Phe Ala Thr 
     130                135                140
Ile His Thr Asp Ser Ser Leu Leu Leu Ala Asp Ile Thr Asp Lys Phe 
 145                150                155                160
Gly Gln Arg Ala Phe Val Gly Lys Val Cys Met Asp Leu Asn Asp Thr 
                 165                170                175
Phe Pro Glu Tyr Lys Glu Thr Thr Glu Glu Ser Ile Lys Glu Thr Glu 
             180                185                190
Arg Phe Val Ser Glu Met Leu Gln Lys Asn Tyr Ser Arg Val Lys Pro 
         195                200                205
Ile Val Thr Pro Arg Phe Ser Leu Ser Cys Ser Glu Thr Leu Met Gly 
     210                215                220
Glu Leu Gly Asn Ile Ala Lys Thr Arg Asp Leu His Ile Gln Ser His 
 225                230                235                240
Ile Ser Glu Asn Arg Asp Glu Val Glu Ala Val Lys Asn Leu Tyr Pro 
                 245                250                255
Ser Tyr Lys Asn Tyr Thr Ser Val Tyr Asp Lys Asn Asn Leu Leu Thr 
             260                265                270
Asn Lys Thr Val Met Ala His Gly Cys Tyr Leu Ser Ala Glu Glu Leu 
         275                280                285
Asn Val Phe His Glu Arg Gly Ala Ser Ile Ala His Cys Pro Asn Ser 
     290                295                300
Asn Leu Ser Leu Ser Ser Gly Phe Leu Asn Val Leu Glu Val Leu Lys 
 305                310                315                320
His Glu Val Lys Ile Gly Leu Gly Thr Asp Val Ala Gly Gly Tyr Ser 
                 325                330                335
Tyr Ser Met Leu Asp Ala Ile Arg Arg Ala Val Met Val Ser Asn Ile 
             340                345                350
Leu Leu Ile Asn Lys Val Asn Glu Lys Ser Leu Thr Leu Lys Glu Val 
         355                360                365
Phe Arg Leu Ala Thr Leu Gly Gly Ser Gln Ala Leu Gly Leu Asp Gly 
     370                375                380
Glu Ile Gly Asn Phe Glu Val Gly Lys Glu Phe Asp Ala Ile Leu Ile 
 385                390                395                400
Asn Pro Lys Ala Ser Asp Ser Pro Ile Asp Leu Phe Tyr Gly Asp Phe 
                 405                410                415
Phe Gly Asp Ile Ser Glu Ala Val Ile Gln Lys Phe Leu Tyr Leu Gly 
             420                425                430
Asp Asp Arg Asn Ile Glu Glu Val Tyr Val Gly Gly Lys Gln Val Val 
         435                440                445
Pro Phe Ser Ser Ser Val 
     450



<210> 5008
<211> 3346
<212> DNA
<213> Rattus norvegicus
<308> AF031381
<400> 5008

ggtcatagc  cttagtgtg  gtggtggca  ctggcatct  accctgcaa  ggtgttggg  60
attatgtgc  gcaascagt  attagagat  tgcttctgg  gtctcmagg  scctgttgg  120
atagtgtga  attaaaccc  gggaggtga  gggtctctt  acaagagaa  actttatgt  180
acactggct  tccctggag  aaaagacgg  tccaacatt  actgaatct  tgtcctttc  240
cagggctgt  gctagggtg  ttagtcagt  tttttagga  gggctgagc  aaggaatag  300
aacatggat  atttagaag  tcycttttt  tyctttttt  ccagagtca  ttatttctg  360
aattcaagg  gatattgaa  aagctaaaa  gcaactgga  ttacccgaa  atttgaaac  420
caaagatga  aatttcttc  aagtttcta  aggcaaaat  atgaatggc  actaatgaa  480
agtccctta  ctgcctacc  ctagtgtca  gcatagtgt  acagtgctt  tgatacact  540
tcatctkga  catatttta  atcaagcgt  ttcctgtag  tgtcaagtg  tctccagca  600
ttcactcca  catgttgca  agtactaag  gactcattc  gaaatcaag  ctttagatg  660
aatatgttg  ttaaaatgt  gcactaaga  agcttgtac  gaaaataaa  tctgtgagt  720
tgggtggaa  agcaagttc  tgaggaaaa  gaggactga  catagttct  gtgactgag  780
gtgctggca  tggtgagcc  agccagcct  tgctgaaca  aggcttttc  ggaagtgca  840
cacacacac  cacacacac  cacacacac  cagagctta  ccatgaagg  aaaattaga  900
ttacttttc  cattttgtg  attgatata  ttttacaat  ctgcaaact  ccttgagtc  960
ctcacgact  cccctgagg  cacttcctg  tagtgtccc  atgctctgt  tgcagttac  1020
tcaggttga  gttgccttt  atcgcctgc  cctcatcag  gcttttgct  ttcttcaaa  1080
tactgagga  ccaacccag  gccttacac  ccaggcaag  gtgaccact  agctaggct  1140
ccgccccct  tactttttg  agccataca  tggatgtct  tatgttgcc  ttttgaaga  1200
taggtggtt  tgctcttta  catttttgt  actttggtt  attttcttc  catgtcgcc  1260
agagattac  tgtgtgtgt  ccattctgc  caaaactaa  tggtggtca  gttcaagta  1320
agaaaaata  aacaagctg  atttataga  ttgcttgga  ttgaaatga  catagccag  1380
tcctaccca  ccctgccct  ccttttttt  ttttttaaa  tgtggtcct  tgctttcaa  1440
ctaagtaca  ttctctatg  ccaggcact  aaacataat  taaaagtcc  tgatgcttc  1500
gaaccggat  agttccagt  gcatatctc  atatctcct  tttccctct  gttttcccc  1560
ggttcctcc  ctttccctc  tggtgcctg  gttgttatg  tggcagaag  ttgacattg  1620
atgctcgat  gcttcagcc  caccggggc  ttgaatcat  atttgttga  tggcaacag  1680
ttgctgggg  agaggcact  cctaagtgg  gcatgcacg  gaaaataga  aggtaattt  1740
acaacacac  gacacccag  gacttggtc  cttgcatgt  tgtagaagt  gtggtbtgg  1800
gasggatgg  actcactca  ccctgtgaa  gtgttctat  gctgagcaa  attcctagc  1860
ttcagaata  aatttttga  gttggaaat  ctgtattta  aggaaacct  aattatcaa  1920
ggatttatg  aggaaagtt  aaaacaaat  tgcacagta  aaaatagat  tgtggcttt  1980
tttttttaa  gtaagaata  cttgttagt  tatcaatgt  catgggtaa  gttatctca  2040
tttgttagt  gttattttg  aattacatg  tgtgtgatt  agggcttag  taattctct  2100
gaattcaaa  actattatt  atgtattaa  agaaattac  gtaccacgt  gattagtct  2160
aatgtttgc  ggcattgga  taaaatttg  cttattttt  ccctcttcc  ctgtcaacc  2220
gaatcctgt  tctgtttgg  gtatactgg  tgtttgtta  tatacacct  tatttacaa  2280
cctgagtag  cctatcaag  aagggtgct  atgtgacta  gagctttat  ttcaaggac  2340
ctccccctc  cagtccccc  atctcaggg  gtctttcct  cttttaaaa  accttacaa  2400
gtctctata  ctggctatc  ttgaaagta  agagatcca  gtgtgtctt  ccttctgaa  2460
gctgggatt  aaagtgtgc  tcaagcctg  ccaagacac  cacaccabc  ccaccacca  2520
ccacccacc  ctttaaaat  cctgtagca  ggtgacttt  catggaaag  attcagagg  2580
tatcattac  caaaaagtc  actctttaa  aataaaggt  cctattggg  gctaaagga  2640
ccagacaag  ctaactcct  tataatcct  aagattgtt  tgtaaccat  gatgtgcca  2700
aaccccaca  attgctgca  ggcattctt  ccatttgtt  caaagaagt  catttcagc  2760
ctcatctga  tgaactctg  gatgactta  ccagcttgc  ggtagggca  ttaggtgat  2820
gggaggtgt  agaaccagt  acttgaaac  tacaaggac  atcttcctt  cccagtgct  2880
ttgtcttcc  gttccccct  gtacttggg  cagaaatga  actgataga  aaaaatcag  2940
ttgattgtt  agagactga  ctagaaaac  aatcagatc  gccaaagag  atgtgatca  3000
aagtcagaa  cactggatg  agagttttc  acagacagc  gagagtgag  tcttgaaag  3060
actgcattc  tgagagtta  agagttttc  aactccatg  aagttacag  gacaaagtt  3120
agagctgag  tggaaggaa  gaccatcca  agactgacc  acatgggga  ctatcccat  3180
tacaaccac  aaactccga  actattgna  atggcaaca  gattttgct  acaggaacc  3240
gacatacct  tcttgtgag  ctatgccag  gactggcaa  tacagaagt  gatgctctc  3300
gtcatctat  ggatggagc  cagggtccc  aatgaagga  ctcgag  3346



<210> 5009
<211> 42
<212> PRT
<213> Rattus norvegicus
<308> AAB86495
<400> 5009

Ser Leu Ile Ser Ala Ile Gln Gly Asp Ile Glu Glu Ala Lys Lys Gln 
  1               5                  10                  15
Leu Asp Leu Pro Glu His Leu Lys Leu Lys Asp Asp Asn Phe Phe Gln 
             20                  25                  30
Val Ser Lys Gly Lys Ile Met Asn Gly His 
         35                  40



<210> 5010
<211> 2617
<212> DNA
<213> Homo sapiens
<308> NM_018339
<400> 5010

acttcggct  tctccgctg  cctccagcg  agacgcagc  cctcaggcg  ccggcggta  60
ttgttgggt  ggcggcgtc  gggattcgc  gtggcctgt  gtcggcgtc  tccggccac  120
ggtgcgccc  cgcgacagg  agagctcac  ctcctgtcc  ccggctggt  cggggtctg  180
gcgccgcgt  gacggcggc  ccgcaggac  cgcagaccg  gccgcagcc  atgccccga  240
cggactgca  tatgaggca  ctgccttac  tctgccggg  tcaagtggt  cggggcttc  300
gccgcggct  caagcagct  ggcatcccc  cagctaatt  tcctgagca  gtggtagat  360
atcttccag  tgatatatc  actggtatt  actatggtt  ggccagtgt  ggaagtgga  420
atgtccata  gatggtggt  agcatagga  ggaacccat  ttacaagaa  acgaagaag  480
ctatggaaa  acatatcat  cataccttc  aagaggact  ctatgggga  atcctcaat  540
tcgccattg  tggctacct  agaccagaa  agaactttg  ttctttaga  tcacttatt  600
cagcaattc  aggtgatat  gaagaagct  agaaacgac  agagttacc  gaacatttg  660
aaatcaaag  agacaattt  ttccaggtt  ctaaaagca  aataatgaa  ggccactga  720
gaaaaattg  attatttat  cattcactg  tttctagtg  ttctgtgtt  attactgtt  780
agcatcatc  tggttatat  ctgaaaatc  aacacttta  tacagttgt  aattagttt  840
aaccgtaca  tgttgttat  atatcatgc  tcaactatt  aattaagcc  atcatatca  900
agcactaaa  agattgagt  aaaaataag  tttaaaaaa  atatattga  taaaatgta  960
cactagaaa  gtgttacat  tgtataagt  tgggtaaaa  ggcaagtca  tagtttgag  1020
tgaaaacta  aattttcat  gtaaaatgc  agcatgtat  tacttgtgt  gtgtgtact  1080
ctaaacaga  aaggcttat  aaagtaaat  cattaaggc  aagtgcagt  gctcacacc  1140
gtaatccca  cactttggg  ggccgaggt  ggaggattg  ttgagctca  gagttcaag  1200
ccagtctgg  caacatagc  agactccat  tctataaat  aaaaaaaag  aaatgcatt  1260
aatagaagg  tgatagttt  tcataaacc  gcggggaag  aactcagac  ttctatttt  1320
gatattttg  gcattaata  attacaaac  tgaagatgt  tgtaaagtt  tgttttagt  1380
attttcttt  cagtcacat  attgtacca  cttcattat  gtatagagc  gcttcaatt  1440
tgagtcctc  ggacttccc  tgcctatct  tttgttgtt  ttgttgaag  cagtaaaat  1500
agtgttttc  aatctatat  tctcctttt  gttggataa  gtttcttct  tttaatggt  1560
aatattctt  ttcttcaac  tttttcttt  gttcttttt  cctttttta  gaaaaacaa  1620
acaacagac  tcatcctta  gttttctca  gatttaagt  aacacattt  cacatatca  1680
tttcttaaa  aacacaaaa  gtttcctcc  tagcaaaac  atttaagag  caattaaac  1740
atgaaatag  tataaaatt  tttttaata  ttaaggcct  gaaattata  tccaaggca  1800
atctaaatg  gtgtagttg  atatgcacg  tgtaattta  tgctaaaga  tacttacag  1860
ttgagggaa  agcataaag  tttagttaa  tagccttca  actgtggat  tttcctcct  1920
ctaactaat  tgtgggaaa  taagattac  gatgctttg  gccccctca  acagtacat  1980
gctacagtt  actgtagca  cagatttgg  ggtgatggg  ggatagagg  agaagcaga  2040
agaaggtaa  tttaaagtt  atttattat  aatcatttt  ccctaatct  cataaatga  2100
ttagaactg  ttttaataa  aatattctg  gtaaaaagt  ctcagaaaa  catctaaag  2160
tgttggaga  gagggactc  tataaatag  tggattgcg  tttgctttt  atttcttta  2220
aaaaatatg  caaaaacag  ttttaattt  agaaatctt  tacttgaaa  aaacctcaa  2280
tatcagtgg  tttatgaag  aaagttaaa  acaaacata  gaaatgtga  aatatttgt  2340
tttgttttg  ctgactaac  tgctgctaa  tgctatctt  aggtgtgtg  aagttcttt  2400
atatgttat  gtcctttta  atcttgtta  atagccatt  cttttgaga  tcagatagt  2460
tgttgttta  gggttaatt  tgtctatat  tttcaaaaa  ttttatatt  tgtattata  2520
gaagttaca  tagtaccat  ttgattagt  tgaatgttt  caggccttg  aataaattt  2580
gactaagta  aaaaaaaaa  aaaaaaaaa  aaaaaaa  2617



<210> 5011
<211> 162
<212> PRT
<213> Homo sapiens
<308> NP_060809
<400> 5011

Met Pro Arg Ala Asp Cys Ile Met Arg His Leu Pro Tyr Phe Cys Arg 
  1               5                  10                  15
Gly Gln Val Val Arg Gly Phe Gly Arg Gly Ser Lys Gln Leu Gly Ile 
             20                  25                  30
Pro Thr Ala Asn Phe Pro Glu Gln Val Val Asp Asn Leu Pro Ala Asp 
         35                  40                  45
Ile Ser Thr Gly Ile Tyr Tyr Gly Trp Ala Ser Val Gly Ser Gly Asp 
     50                  55                  60
Val His Lys Met Val Val Ser Ile Gly Trp Asn Pro Tyr Tyr Lys Asn 
 65                  70                  75                  80
Thr Lys Lys Ser Met Glu Thr His Ile Met His Thr Phe Lys Glu Asp 
                 85                  90                  95
Phe Tyr Gly Glu Ile Leu Asn Val Ala Ile Val Gly Tyr Leu Arg Pro 
             100                105                110
Glu Lys Asn Phe Asp Ser Leu Glu Ser Leu Ile Ser Ala Ile Gln Gly 
         115                120                125
Asp Ile Glu Glu Ala Lys Lys Arg Leu Glu Leu Pro Glu His Leu Lys 
     130                135                140
Ile Lys Glu Asp Asn Phe Phe Gln Val Ser Lys Ser Lys Ile Met Asn 
 145                150                155                160
Gly His 
                 165



<210> 5012
<211> 599
<212> DNA
<213> Rattus norvegicus
<308> AA859897
<400> 5012

ttttttttt  tttttttag  cagagatgg  atctttatt  cacaagttt  aagatacag  60
acaaaatga  tctgtacat  tctctatta  caggatttg  ttacacaat  ataatacac  120
tcaccagcc  ttatactgc  ttccattaa  tataaaata  atttacaaa  agtctagta  180
ggtgttcct  cacaatgtc  gcttatgtt  tttaaatac  tccctcagc  tttatagtg  240
tcatatttt  atcatatca  cattgtttt  aaataaaag  gaaatagtg  cagatcgtt  300
accaataaa  agtaaagga  gaacatctg  atgcctcct  gaacataac  aaaggggcc  360
ttcatctgc  tacaaaacc  gcttttaat  tgtaaacag  ctctttaag  tacagatca  420
tggtatatg  ggctatttc  ctangggta  tttcttgaa  cccctaatg  gtgaagaca  480
ttaggtcct  tttcaaaga  cactactca  ttaaaaacc  gacaatata  catccagaa  540
tagtttctc  cgtatctga  caaattttt  ttttgcata  aattgtttt  ttttttttt  599



<210> 5013
<211> 151
<212> PRT
<213> Rattus norvegicus
<308> AF304855
<400> 5013

Glu Asp Ala Ala Lys Arg Arg Gln Met Gln Glu Ala Glu Ala Ile Tyr 
  1               5                  10                  15
Gln Ser Gly Met Lys Ile Leu Asn Gly Ser Thr Arg Lys Asn Gln Lys 
             20                  25                  30
Arg Glu Ala Tyr Arg Tyr Leu Gln Lys Ala Ala Gly Met Asn His Thr 
         35                  40                  45
Lys Ala Leu Glu Arg Val Ser Tyr Ala Leu Leu Phe Gly Asp Tyr Leu 
     50                  55                  60
Thr Gln Asn Ile Gln Ala Ala Lys Glu Met Phe Glu Lys Leu Thr Glu 
 65                  70                  75                  80
Glu Gly Ser Pro Lys Gly Gln Thr Gly Leu Gly Phe Leu Tyr Ala Ser 
                 85                  90                  95
Gly Leu Gly Val Asn Ser Ser Gln Ala Lys Ala Leu Val Tyr Tyr Thr 
             100                105                110
Phe Gly Ala Leu Gly Gly Asn Leu Ile Ala His Met Val Leu Gly Tyr 
         115                120                125
Arg Tyr Trp Ala Gly Ile Gly Val Leu Gln Ser Cys Glu Ser Ala Leu 
     130                135                140
Thr His Tyr Arg Leu Glu Ser 
 145                150



<210> 5014
<211> 3444
<212> DNA
<213> Homo sapiens
<308> XM_007325
<400> 5014

aagagcagc  gcgaggcgg  ggtggtggc  gagtccgtg  tggcagagg  gaaggcgac  60
gctctaggg  ttggcaccg  ccccgagag  aggatgcgg  tccggatag  gctgacgct  120
ctgctgtgt  cggtgctgc  gagcttggc  tcggcgtcc  cggatgaag  aggcagcca  180
gatgaatcc  tagattcca  gactacttt  acatcagat  agtcagtaa  ggaccatac  240
actgcaggc  gagtagttg  tggtcaaat  tttcttgat  cagaagaat  tgaattaga  300
tcctctatt  aagaagagg  agacagcct  aagagccaa  agggggaaa  tgtcacaga  360
gatatcagc  ttctagagt  tccaaatcc  gaaaacaag  actatgaag  gccaaagaa  420
gtacggaaa  cagctttga  cgccattga  ggcacagca  atggggagc  ctgccactt  480
ccttttctt  tcctagata  ggagtatga  gaatgtaca  cagatggga  ggaagatgg  540
agactgtgg  gtgctacaa  ctatgacta  aaagcagat  aaaagtggg  cttttgtga  600
actgaagaa  aggctgcta  gagacggca  atgcaggaa  cagaaatga  gtatcaaac  660
ggaatgaaa  tccttaatg  aagcaataa  aaaagccaa  aaagagaag  atatcggta  720
ctccaaaag  cagcaagca  gaaccatac  aaagccctg  agagagtgt  atatgctct  780
ttatttggt  attacttgc  acagaatat  caggcagcg  gagagatgt  tgagaagct  840
actgaggaa  gctctccca  gggacagac  gctcttggc  ttctgtatg  ctctggact  900
ggtgttaat  caagtcagg  aaaggctct  gtatattat  catttggag  tcttggggg  960
aatctaata  cccacatgg  tttgggtta  agatactgg  ctggcatcg  cgtcctcca  1020
agttgtgaa  ctgccctga  tcactatcg  cttgttgcc  atcatgttg  tagtgatat  1080
tcgctaaca  gaggctcag  agtacagag  atacggctg  ctgatgaag  ggaaaatcc  1140
ggaatgaac  gtggaatgc  agaagaaga  ttgattcaa  attaccagt  cctagctga  1200
aaaggtgat  tacaagcac  ggttggtct  ggacaactg  acctgcacg  agggcgtgg  1260
gtagaacag  atcatcaga  agcatttga  tacttcaat  tagcagcaa  tgctggcaa  1320
tcacatgcc  tggcctttt  gggaaagat  tattcggaa  gaagtgaca  tgtacctca  1380
agtaatgag  cagctctcc  ctactttaa  aaagctgct  acatgggca  cccagttgg  1440
cagagtggg  ttggaatgg  ctacctcta  gggagagga  ttcaagtta  ttatgatct  1500
gcccttaag  atttccaga  agctgctga  caaggctgg  tggatgggc  gctacagct  1560
ggttccatg  actataatg  cattggagt  aagagagat  ataaacagg  cttgaagta  1620
tttaattta  cttctcagg  aggccatat  ttggctttc  ataacctag  tcagatgca  1680
gccagtggc  ccggcgtga  gcgatcatg  cacactgca  tggagttgt  taagaatgt  1740
tgtgaacga  gccgttggt  tgaaaggct  atgactgcc  ataacagct  taaagatgg  1800
gattacaat  ctgcagtga  ccagtacct  ctcctggct  aacagggct  tgaagtggc  1860
caaagcaat  cagccttta  tcttgatca  agagaagca  gcattgtag  tgagaatga  1920
acttatccc  gagctttgc  acattggaa  agggccgcc  ctcaaggct  tactgtggc  1980
agaattaag  tcggagact  ccatttcta  gggtttggc  ccgatgtag  ttatgaaac  2040
gcatttatt  attaccgtc  ggcttctga  cagcaacac  gtgcacaag  tatgtttaa  2100
ctgggatat  tgcatgaga  aggactggg  attaaacag  atattcacc  tgcgaaacg  2160
ttttatgac  tggcagctg  agccagccc  gatgcacaa  ttccagtct  cctagccct  2220
tgcaaattg  gcgtcgtct  tttcttgca  tacatacgg  aaacaaaca  tcgagatat  2280
ttcacccaa  ttgatatgg  ccagctttt  ggacctgag  gggaccttt  cctcatgac  2340
atcattgcg  tgctgttgg  aacagtcat  gcttacagg  aaaggcagc  ccaagacat  2400
cctgcaccc  ggcctccag  gccacggcc  gctccaccc  agcaggagg  gccaccaga  2460
cagcagcca  cacagtaat  ggcactggg  ccagccttg  tcagtgaca  cgaaggaag  2520
tatctgctg  gaacacttg  atttgattt  ggaccttgg  tcagtggtc  cctcccaga  2580
gaggcacgg  acaaggaag  attgaattc  taaagctgc  tagaatctg  tgcctttat  2640
ttcagggat  agtaactct  acctaaact  agctgaatg  ttgtttcag  gccatatgg  2700
ataacaact  tcagtggct  ttttttttc  tttctggaa  catatgtga  acactcaga  2760
taatgtcta  tgtatccag  tatctttct  ggatccttt  ggtcattat  tcagtgtgc  2820
taagttctt  atgtcaacc  tctttaagg  attgtgcat  gacactaaa  actgatcag  2880
gtaaaaagg  aaacccagt  gcaagttta  acgtgttcg  aagtctgaa  atagaactt  2940
ccttttaag  taaaaaaaa  aaaagctat  ttgaaaatg  tttggaact  cgataactg  3000
gaaactctt  ccagtccac  tgcaattag  catattcag  atatttgtt  ttttaaaag  3060
gagggttgg  aggtttctt  ttggtgatt  tcacacggt  taccatact  ctctccttc  3120
aagaatgaa  ggccttgtt  aggagtttt  tgtgagctt  acttctttg  aatggaata  3180
acttatgca  aaccttgtg  actgactcc  tgcactaac  cgagtttgc  ccacctact  3240
tgtaatttg  ttgtttgtt  tgaatatac  gagccttga  ccagaagcc  gaggatgga  3300
taagtggga  aaattagaa  acaaaacga  ctctggttg  ggtactacg  tcacagaca  3360
agacatact  ttcctaaag  tgaagcatt  gttcccagg  tttatttta  tttgcattt  3420
tttttgcac  aagaacaca  cacc  3444



<210> 5015
<211> 794
<212> PRT
<213> Homo sapiens
<308> XP_007325
<400> 5015

Met Arg Val Arg Ile Gly Leu Thr Leu Leu Leu Cys Ala Val Leu Leu 
  1               5                  10                  15
Ser Leu Ala Ser Ala Ser Ser Asp Glu Glu Gly Ser Gln Asp Glu Ser 
             20                  25                  30
Leu Asp Ser Lys Thr Thr Leu Thr Ser Asp Glu Ser Val Lys Asp His 
         35                  40                  45
Thr Thr Ala Gly Arg Val Val Ala Gly Gln Ile Phe Leu Asp Ser Glu 
     50                  55                  60
Glu Ser Glu Leu Glu Ser Ser Ile Gln Glu Glu Glu Asp Ser Leu Lys 
 65                  70                  75                  80
Ser Gln Glu Gly Glu Ser Val Thr Glu Asp Ile Ser Phe Leu Glu Ser 
                 85                  90                  95
Pro Asn Pro Glu Asn Lys Asp Tyr Glu Glu Pro Lys Lys Val Arg Lys 
             100                105                110
Pro Ala Leu Thr Ala Ile Glu Gly Thr Ala His Gly Glu Pro Cys His 
         115                120                125
Phe Pro Phe Leu Phe Leu Asp Lys Glu Tyr Asp Glu Cys Thr Ser Asp 
     130                135                140
Gly Arg Glu Asp Gly Arg Leu Trp Cys Ala Thr Thr Tyr Asp Tyr Lys 
 145                150                155                160
Ala Asp Glu Lys Trp Gly Phe Cys Glu Thr Glu Glu Glu Ala Ala Lys 
                 165                170                175
Arg Arg Gln Met Gln Glu Ala Glu Met Met Tyr Gln Thr Gly Met Lys 
             180                185                190
Ile Leu Asn Gly Ser Asn Lys Lys Ser Gln Lys Arg Glu Ala Tyr Arg 
         195                200                205
Tyr Leu Gln Lys Ala Ala Ser Met Asn His Thr Lys Ala Leu Glu Arg 
     210                215                220
Val Ser Tyr Ala Leu Leu Phe Gly Asp Tyr Leu Pro Gln Asn Ile Gln 
 225                230                235                240
Ala Ala Arg Glu Met Phe Glu Lys Leu Thr Glu Glu Gly Ser Pro Lys 
                 245                250                255
Gly Gln Thr Ala Leu Gly Phe Leu Tyr Ala Ser Gly Leu Gly Val Asn 
             260                265                270
Ser Ser Gln Ala Lys Ala Leu Val Tyr Tyr Thr Phe Gly Ala Leu Gly 
         275                280                285
Gly Asn Leu Ile Ala His Met Val Leu Gly Tyr Arg Tyr Trp Ala Gly 
     290                295                300
Ile Gly Val Leu Gln Ser Cys Glu Ser Ala Leu Thr His Tyr Arg Leu 
 305                310                315                320
Val Ala Asn His Val Ala Ser Asp Ile Ser Leu Thr Gly Gly Ser Val 
                 325                330                335
Val Gln Arg Ile Arg Leu Pro Asp Glu Val Glu Asn Pro Gly Met Asn 
             340                345                350
Ser Gly Met Leu Glu Glu Asp Leu Ile Gln Tyr Tyr Gln Phe Leu Ala 
         355                360                365
Glu Lys Gly Asp Val Gln Ala Gln Val Gly Leu Gly Gln Leu His Leu 
     370                375                380
His Gly Gly Arg Gly Val Glu Gln Asn His Gln Arg Ala Phe Asp Tyr 
 385                390                395                400
Phe Asn Leu Ala Ala Asn Ala Gly Asn Ser His Ala Met Ala Phe Leu 
                 405                410                415
Gly Lys Met Tyr Ser Glu Gly Ser Asp Ile Val Pro Gln Ser Asn Glu 
             420                425                430
Thr Ala Leu His Tyr Phe Lys Lys Ala Ala Asp Met Gly Asn Pro Val 
         435                440                445
Gly Gln Ser Gly Leu Gly Met Ala Tyr Leu Tyr Gly Arg Gly Val Gln 
     450                455                460
Val Asn Tyr Asp Leu Ala Leu Lys Tyr Phe Gln Lys Ala Ala Glu Gln 
 465                470                475                480
Gly Trp Val Asp Gly Gln Leu Gln Leu Gly Ser Met Tyr Tyr Asn Gly 
                 485                490                495
Ile Gly Val Lys Arg Asp Tyr Lys Gln Ala Leu Lys Tyr Phe Asn Leu 
             500                505                510
Ala Ser Gln Gly Gly His Ile Leu Ala Phe Tyr Asn Leu Ala Gln Met 
         515                520                525
His Ala Ser Gly Thr Gly Val Met Arg Ser Cys His Thr Ala Val Glu 
     530                535                540
Leu Phe Lys Asn Val Cys Glu Arg Gly Arg Trp Ser Glu Arg Leu Met 
 545                550                555                560
Thr Ala Tyr Asn Ser Tyr Lys Asp Gly Asp Tyr Asn Ala Ala Val Ile 
                 565                570                575
Gln Tyr Leu Leu Leu Ala Glu Gln Gly Tyr Glu Val Ala Gln Ser Asn 
             580                585                590
Ala Ala Phe Ile Leu Asp Gln Arg Glu Ala Ser Ile Val Gly Glu Asn 
         595                600                605
Glu Thr Tyr Pro Arg Ala Leu Leu His Trp Asn Arg Ala Ala Ser Gln 
     610                615                620
Gly Tyr Thr Val Ala Arg Ile Lys Leu Gly Asp Tyr His Phe Tyr Gly 
 625                630                635                640
Phe Gly Thr Asp Val Asp Tyr Glu Thr Ala Phe Ile His Tyr Arg Leu 
                 645                650                655
Ala Ser Glu Gln Gln His Ser Ala Gln Ala Met Phe Asn Leu Gly Tyr 
             660                665                670
Met His Glu Lys Gly Leu Gly Ile Lys Gln Asp Ile His Leu Ala Lys 
         675                680                685
Arg Phe Tyr Asp Met Ala Ala Glu Ala Ser Pro Asp Ala Gln Val Pro 
     690                695                700
Val Phe Leu Ala Leu Cys Lys Leu Gly Val Val Tyr Phe Leu Gln Tyr 
 705                710                715                720
Ile Arg Glu Thr Asn Ile Arg Asp Met Phe Thr Gln Leu Asp Met Asp 
                 725                730                735
Gln Leu Leu Gly Pro Glu Trp Asp Leu Tyr Leu Met Thr Ile Ile Ala 
             740                745                750
Leu Leu Leu Gly Thr Val Ile Ala Tyr Arg Gln Arg Gln His Gln Asp 
         755                760                765
Met Pro Ala Pro Arg Pro Pro Gly Pro Arg Pro Ala Pro Pro Gln Gln 
     770                775                780
Glu Gly Pro Pro Glu Gln Gln Pro Pro Gln 
 785                790



<210> 5016
<211> 464
<212> DNA
<213> Rattus norvegicus
<308> AA859911
<400> 5016

ttttttttt  ttttgttcc  ttttttccc  ttgagaaag  gtctcatat  tcccaggtt  60
gtttgaaag  taccatata  ctgaggcta  cctttaact  actttcctg  tgcagactc  120
taactgcta  gattaaagg  acataccac  atgcctggc  taataaatt  atttttcca  180
accataata  tcatccctc  gtgggggga  ttcggagtg  agagcccat  aaaaggctt  240
tcaggtgta  gaggttatc  gagttgcct  gttccccca  acatcttta  ctcctcaga  300
tcacctatg  ggggtacag  tcagaacag  tgagtaact  tatggactt  gttcttttt  360
attcacgaa  agaaacaga  ggaaaaatt  aatgtttaa  taactgtac  agaaaaacg  420
tgtgggtgc  gggacctac  ttttctaga  tggtgactc  tggt  464



<210> 5017
<211> 350
<212> PRT
<213> Rattus norvegicus
<308> Q11205
<400> 5017

Met Lys Cys Ser Leu Arg Val Trp Phe Leu Ser Met Ala Phe Leu Leu 
  1               5                  10                  15
Val Phe Ile Met Ser Leu Leu Phe Thr Tyr Ser His His Ser Met Ala 
             20                  25                  30
Thr Leu Pro Tyr Leu Asp Ser Gly Thr Leu Gly Gly Thr His Arg Val 
         35                  40                  45
Lys Leu Val Pro Gly Tyr Thr Gly Gln Gln Arg Leu Val Lys Glu Gly 
     50                  55                  60
Leu Ser Gly Lys Ser Cys Thr Cys Ser Arg Cys Met Gly Asp Ala Gly 
 65                  70                  75                  80
Thr Ser Glu Trp Phe Asp Ser His Phe Asp Ser Asn Ile Ser Pro Val 
                 85                  90                  95
Trp Thr Arg Asp Asn Met Asn Leu Thr Pro Asp Val Gln Arg Trp Trp 
             100                105                110
Met Met Leu Gln Pro Gln Phe Lys Ser His Asn Thr Asn Glu Val Leu 
         115                120                125
Glu Lys Leu Phe Gln Ile Val Pro Gly Glu Asn Pro Tyr Arg Phe Arg 
     130                135                140
Asp Pro Gln Gln Cys Arg Arg Cys Ala Val Val Gly Asn Ser Gly Asn 
 145                150                155                160
Leu Arg Gly Ser Gly Tyr Gly Gln Glu Val Asp Ser His Asn Phe Ile 
                 165                170                175
Met Arg Met Asn Gln Ala Pro Thr Val Gly Phe Glu Lys Asp Val Gly 
             180                185                190
Ser Arg Thr Thr His His Phe Met Tyr Pro Glu Ser Ala Lys Asn Leu 
         195                200                205
Pro Ala Asn Val Ser Phe Val Leu Val Pro Phe Lys Ala Leu Asp Leu 
     210                215                220
Met Trp Ile Ala Ser Ala Leu Ser Thr Gly Gln Ile Arg Phe Thr Tyr 
 225                230                235                240
Ala Pro Val Lys Ser Phe Leu Arg Val Asp Lys Glu Lys Val Gln Ile 
                 245                250                255
Tyr Asn Pro Ala Phe Phe Lys Tyr Ile His Asp Arg Trp Thr Glu His 
             260                265                270
His Gly Arg Tyr Pro Ser Thr Gly Met Leu Val Leu Phe Phe Ala Leu 
         275                280                285
His Val Cys Asp Glu Val Asn Val Tyr Gly Phe Gly Ala Asp Ser Arg 
     290                295                300
Gly Asn Trp His His Tyr Trp Glu Asn Asn Arg Tyr Ala Gly Glu Phe 
 305                310                315                320
Arg Lys Thr Gly Val His Asp Ala Asp Phe Glu Ala His Ile Ile Asp 
                 325                330                335
Ile Leu Ala Lys Ala Ser Lys Ile Glu Val Tyr Arg Gly Asn 
             340                345                350



<210> 5018
<211> 1623
<212> DNA
<213> Homo sapiens
<308> X96667
<400> 5018

accagggtg  caggagagg  agagcctct  tggcctagc  agtgacgga  agacccgat  60
aagccctaa  caggggccc  gcctgactc  gggacagga  agccactcc  gccaacgtg  120
gttctccct  catgaggga  ggcgtggca  gggacccct  ccactgtcc  ctgctgcag  180
acgtgcccc  atgcccttt  catgtggtg  cagaatagg  aggctacgc  gtggctggc  240
cctcagcgg  ctgggaaaa  agtggccac  gtgaccgtc  cccgcctgc  ggcaccatg  300
agtgctccc  gcgggtgtg  ttcctctcc  tggccttcc  gctggtgtt  atcatgtcc  360
tgctcttca  ctactcgca  cacagcatg  ccacgctcc  ctacctgga  tcaggggcc  420
tggatggga  gcaccgggt  aagctggtg  ccggctatg  cggcctgca  cgcctcagc  480
aggagaggc  ctcgggcaa  agctgtgcc  gtcgccgct  catgggcga  gccggtgcc  540
ccgactggt  tgacagcca  tttgacggt  acatttccc  cgtctggac  cgagagaac  600
tggatcttc  accggacgt  cagaggtgg  ggatgatgc  gcagcccca  ttcaagtca  660
acaacacca  tgaggtgct  gagaagctg  tccagatag  gcctggcga  aacccctac  720
gcttccggg  cccccacca  tgccggcgc  gtgccgtgg  ggggaactc  ggcaacctg  780
ggggctctg  ctatgggca  gacgtggac  ggcacaact  catcatgag  atgaatcag  840
cgccaaccg  gggctttga  caggatgtt  gcagccgaa  cacccacca  ttcatgtac  900
ctgagagtg  caagaacct  cccgccaac  tcagcttcg  gctggtgcc  ttcaaggtc  960
tggaccttc  gtggatcgc  agcgccttg  ccacggggc  gatccgatt  acctacgcc  1020
cagtgaagt  cttccttcg  gtggataaa  aaaaggtcc  gatctacaa  ccagccttc  1080
tcaagtata  ccacgacag  tggacagag  atcacgggc  gtacccttc  acggggatg  1140
tggtgcttt  ctttgccct  catgtgtgt  atgaggtga  cgtgtacgg  ttcggggcc  1200
acagccggg  caactggca  cactactgg  agaacaacc  gtacgcggg  gagttccgg  1260
agactggcg  gcacgacgc  gacttcgag  cccacatca  cgacatgct  gccaaggcc  1320
gcaagatcg  agtctaccg  ggcaactga  ccgggcctc  ccgcgaccc  tccggccca  1380
ctatcgggc  ccggggctc  ggcccggga  ccaggacca  caacccgcg  ccaatcatg  1440
tgcagccca  gggcgtctg  tgtgccccg  caatcacga  actggggga  cggccgggc  1500
tggcaccaa  ctgcgctgc  gtcgggcgg  gcttctgtt  ctcccagcc  atcatgtga  1560
tcaaggaaa  cttccggcg  tgtgtccag  ctcctccaa  caatggcct  cgggggcgg  1620
cca  1623



<210> 5019
<211> 351
<212> PRT
<213> Homo sapiens
<308> X96667
<400> 5019

Met Lys Cys Ser Leu Arg Val Trp Phe Leu Ser Val Ala Phe Leu Leu 
  1               5                  10                  15
Val Phe Ile Met Ser Leu Leu Phe Thr Tyr Ser His His Ser Met Ala 
             20                  25                  30
Thr Leu Pro Tyr Leu Asp Ser Gly Ala Leu Asp Gly Thr His Arg Val 
         35                  40                  45
Lys Leu Val Pro Gly Tyr Ala Gly Leu Gln Arg Leu Ser Lys Glu Arg 
     50                  55                  60
Leu Ser Gly Lys Ser Cys Ala Cys Arg Arg Cys Met Gly Asp Ala Gly 
 65                  70                  75                  80
Ala Ser Asp Trp Phe Asp Ser His Phe Asp Gly Asn Ile Ser Pro Val 
                 85                  90                  95
Trp Thr Arg Glu Asn Met Asp Leu Pro Pro Asp Val Gln Arg Trp Trp 
             100                105                110
Met Met Leu Gln Pro Gln Phe Lys Ser His Asn Thr Asn Glu Val Leu 
         115                120                125
Glu Lys Leu Phe Gln Ile Val Pro Gly Glu Asn Pro Tyr Arg Phe Arg 
     130                135                140
Asp Pro His Gln Cys Arg Arg Cys Ala Val Val Gly Asn Ser Gly Asn 
 145                150                155                160
Leu Arg Gly Ser Gly Tyr Gly Gln Asp Val Asp Gly His Asn Phe Ile 
                 165                170                175
Met Arg Met Asn Gln Ala Pro Thr Val Gly Phe Glu Gln Asp Val Gly 
             180                185                190
Ser Arg Thr Thr His His Phe Met Tyr Pro Glu Ser Ala Lys Asn Leu 
         195                200                205
Pro Ala Asn Val Ser Phe Val Leu Val Pro Phe Lys Val Leu Asp Leu 
     210                215                220
Leu Trp Ile Ala Ser Ala Leu Ser Thr Gly Gln Ile Arg Phe Thr Tyr 
 225                230                235                240
Ala Pro Val Lys Ser Phe Leu Arg Val Asp Lys Glu Lys Val Gln Ile 
                 245                250                255
Tyr Asn Pro Ala Phe Phe Lys Tyr Ile His Asp Arg Trp Thr Glu His 
             260                265                270
His Gly Arg Tyr Pro Ser Thr Gly Met Leu Val Leu Phe Phe Ala Leu 
         275                280                285
His Val Cys Asp Glu Val Asn Val Tyr Gly Phe Gly Ala Asp Ser Arg 
     290                295                300
Gly Asn Trp His His Tyr Trp Glu Asn Asn Arg Tyr Ala Gly Glu Phe 
 305                310                315                320
Arg Lys Thr Gly Val His Asp Ala Asp Phe Glu Ala His Ile Ile Asp 
                 325                330                335
Met Leu Ala Lys Ala Ser Lys Ile Glu Val Tyr Arg Gly Asn Ter 
             340                345                350



<210> 5020
<211> 464
<212> DNA
<213> Rattus norvegicus
<308> AA859911
<400> 5020

ttttttttt  ttttgttcc  ttttttccc  ttgagaaag  gtctcatat  tcccaggtt  60
gtttgaaag  taccatata  ctgaggcta  cctttaact  actttcctg  tgcagactc  120
taactgcta  gattaaagg  acataccac  atgcctggc  taataaatt  atttttcca  180
accataata  tcatccctc  gtgggggga  ttcggagtg  agagcccat  aaaaggctt  240
tcaggtgta  gaggttatc  gagttgcct  gttccccca  acatcttta  ctcctcaga  300
tcacctatg  ggggtacag  tcagaacag  tgagtaact  tatggactt  gttcttttt  360
attcacgaa  agaaacaga  ggaaaaatt  aatgtttaa  taactgtac  agaaaaacg  420
tgtgggtgc  gggacctac  ttttctaga  tggtgactc  tggt  464



<210> 5021
<211> 350
<212> PRT
<213> Rattus norvegicus
<308> Q11205
<400> 5021

Met Lys Cys Ser Leu Arg Val Trp Phe Leu Ser Met Ala Phe Leu Leu 
  1               5                  10                  15
Val Phe Ile Met Ser Leu Leu Phe Thr Tyr Ser His His Ser Met Ala 
             20                  25                  30
Thr Leu Pro Tyr Leu Asp Ser Gly Thr Leu Gly Gly Thr His Arg Val 
         35                  40                  45
Lys Leu Val Pro Gly Tyr Thr Gly Gln Gln Arg Leu Val Lys Glu Gly 
     50                  55                  60
Leu Ser Gly Lys Ser Cys Thr Cys Ser Arg Cys Met Gly Asp Ala Gly 
 65                  70                  75                  80
Thr Ser Glu Trp Phe Asp Ser His Phe Asp Ser Asn Ile Ser Pro Val 
                 85                  90                  95
Trp Thr Arg Asp Asn Met Asn Leu Thr Pro Asp Val Gln Arg Trp Trp 
             100                105                110
Met Met Leu Gln Pro Gln Phe Lys Ser His Asn Thr Asn Glu Val Leu 
         115                120                125
Glu Lys Leu Phe Gln Ile Val Pro Gly Glu Asn Pro Tyr Arg Phe Arg 
     130                135                140
Asp Pro Gln Gln Cys Arg Arg Cys Ala Val Val Gly Asn Ser Gly Asn 
 145                150                155                160
Leu Arg Gly Ser Gly Tyr Gly Gln Glu Val Asp Ser His Asn Phe Ile 
                 165                170                175
Met Arg Met Asn Gln Ala Pro Thr Val Gly Phe Glu Lys Asp Val Gly 
             180                185                190
Ser Arg Thr Thr His His Phe Met Tyr Pro Glu Ser Ala Lys Asn Leu 
         195                200                205
Pro Ala Asn Val Ser Phe Val Leu Val Pro Phe Lys Ala Leu Asp Leu 
     210                215                220
Met Trp Ile Ala Ser Ala Leu Ser Thr Gly Gln Ile Arg Phe Thr Tyr 
 225                230                235                240
Ala Pro Val Lys Ser Phe Leu Arg Val Asp Lys Glu Lys Val Gln Ile 
                 245                250                255
Tyr Asn Pro Ala Phe Phe Lys Tyr Ile His Asp Arg Trp Thr Glu His 
             260                265                270
His Gly Arg Tyr Pro Ser Thr Gly Met Leu Val Leu Phe Phe Ala Leu 
         275                280                285
His Val Cys Asp Glu Val Asn Val Tyr Gly Phe Gly Ala Asp Ser Arg 
     290                295                300
Gly Asn Trp His His Tyr Trp Glu Asn Asn Arg Tyr Ala Gly Glu Phe 
 305                310                315                320
Arg Lys Thr Gly Val His Asp Ala Asp Phe Glu Ala His Ile Ile Asp 
                 325                330                335
Ile Leu Ala Lys Ala Ser Lys Ile Glu Val Tyr Arg Gly Asn 
             340                345                350



<210> 5022
<211> 1623
<212> DNA
<213> Homo sapiens
<308> X96667
<400> 5022

accagggtg  caggagagg  agagcctct  tggcctagc  agtgacgga  agacccgat  60
aagccctaa  caggggccc  gcctgactc  gggacagga  agccactcc  gccaacgtg  120
gttctccct  catgaggga  ggcgtggca  gggacccct  ccactgtcc  ctgctgcag  180
acgtgcccc  atgcccttt  catgtggtg  cagaatagg  aggctacgc  gtggctggc  240
cctcagcgg  ctgggaaaa  agtggccac  gtgaccgtc  cccgcctgc  ggcaccatg  300
agtgctccc  gcgggtgtg  ttcctctcc  tggccttcc  gctggtgtt  atcatgtcc  360
tgctcttca  ctactcgca  cacagcatg  ccacgctcc  ctacctgga  tcaggggcc  420
tggatggga  gcaccgggt  aagctggtg  ccggctatg  cggcctgca  cgcctcagc  480
aggagaggc  ctcgggcaa  agctgtgcc  gtcgccgct  catgggcga  gccggtgcc  540
ccgactggt  tgacagcca  tttgacggt  acatttccc  cgtctggac  cgagagaac  600
tggatcttc  accggacgt  cagaggtgg  ggatgatgc  gcagcccca  ttcaagtca  660
acaacacca  tgaggtgct  gagaagctg  tccagatag  gcctggcga  aacccctac  720
gcttccggg  cccccacca  tgccggcgc  gtgccgtgg  ggggaactc  ggcaacctg  780
ggggctctg  ctatgggca  gacgtggac  ggcacaact  catcatgag  atgaatcag  840
cgccaaccg  gggctttga  caggatgtt  gcagccgaa  cacccacca  ttcatgtac  900
ctgagagtg  caagaacct  cccgccaac  tcagcttcg  gctggtgcc  ttcaaggtc  960
tggaccttc  gtggatcgc  agcgccttg  ccacggggc  gatccgatt  acctacgcc  1020
cagtgaagt  cttccttcg  gtggataaa  aaaaggtcc  gatctacaa  ccagccttc  1080
tcaagtata  ccacgacag  tggacagag  atcacgggc  gtacccttc  acggggatg  1140
tggtgcttt  ctttgccct  catgtgtgt  atgaggtga  cgtgtacgg  ttcggggcc  1200
acagccggg  caactggca  cactactgg  agaacaacc  gtacgcggg  gagttccgg  1260
agactggcg  gcacgacgc  gacttcgag  cccacatca  cgacatgct  gccaaggcc  1320
gcaagatcg  agtctaccg  ggcaactga  ccgggcctc  ccgcgaccc  tccggccca  1380
ctatcgggc  ccggggctc  ggcccggga  ccaggacca  caacccgcg  ccaatcatg  1440
tgcagccca  gggcgtctg  tgtgccccg  caatcacga  actggggga  cggccgggc  1500
tggcaccaa  ctgcgctgc  gtcgggcgg  gcttctgtt  ctcccagcc  atcatgtga  1560
tcaaggaaa  cttccggcg  tgtgtccag  ctcctccaa  caatggcct  cgggggcgg  1620
cca  1623



<210> 5023
<211> 351
<212> PRT
<213> Homo sapiens
<308> X96667
<400> 5023

Met Lys Cys Ser Leu Arg Val Trp Phe Leu Ser Val Ala Phe Leu Leu 
  1               5                  10                  15
Val Phe Ile Met Ser Leu Leu Phe Thr Tyr Ser His His Ser Met Ala 
             20                  25                  30
Thr Leu Pro Tyr Leu Asp Ser Gly Ala Leu Asp Gly Thr His Arg Val 
         35                  40                  45
Lys Leu Val Pro Gly Tyr Ala Gly Leu Gln Arg Leu Ser Lys Glu Arg 
     50                  55                  60
Leu Ser Gly Lys Ser Cys Ala Cys Arg Arg Cys Met Gly Asp Ala Gly 
 65                  70                  75                  80
Ala Ser Asp Trp Phe Asp Ser His Phe Asp Gly Asn Ile Ser Pro Val 
                 85                  90                  95
Trp Thr Arg Glu Asn Met Asp Leu Pro Pro Asp Val Gln Arg Trp Trp 
             100                105                110
Met Met Leu Gln Pro Gln Phe Lys Ser His Asn Thr Asn Glu Val Leu 
         115                120                125
Glu Lys Leu Phe Gln Ile Val Pro Gly Glu Asn Pro Tyr Arg Phe Arg 
     130                135                140
Asp Pro His Gln Cys Arg Arg Cys Ala Val Val Gly Asn Ser Gly Asn 
 145                150                155                160
Leu Arg Gly Ser Gly Tyr Gly Gln Asp Val Asp Gly His Asn Phe Ile 
                 165                170                175
Met Arg Met Asn Gln Ala Pro Thr Val Gly Phe Glu Gln Asp Val Gly 
             180                185                190
Ser Arg Thr Thr His His Phe Met Tyr Pro Glu Ser Ala Lys Asn Leu 
         195                200                205
Pro Ala Asn Val Ser Phe Val Leu Val Pro Phe Lys Val Leu Asp Leu 
     210                215                220
Leu Trp Ile Ala Ser Ala Leu Ser Thr Gly Gln Ile Arg Phe Thr Tyr 
 225                230                235                240
Ala Pro Val Lys Ser Phe Leu Arg Val Asp Lys Glu Lys Val Gln Ile 
                 245                250                255
Tyr Asn Pro Ala Phe Phe Lys Tyr Ile His Asp Arg Trp Thr Glu His 
             260                265                270
His Gly Arg Tyr Pro Ser Thr Gly Met Leu Val Leu Phe Phe Ala Leu 
         275                280                285
His Val Cys Asp Glu Val Asn Val Tyr Gly Phe Gly Ala Asp Ser Arg 
     290                295                300
Gly Asn Trp His His Tyr Trp Glu Asn Asn Arg Tyr Ala Gly Glu Phe 
 305                310                315                320
Arg Lys Thr Gly Val His Asp Ala Asp Phe Glu Ala His Ile Ile Asp 
                 325                330                335
Met Leu Ala Lys Ala Ser Lys Ile Glu Val Tyr Arg Gly Asn Ter 
             340                345                350



<210> 5024
<211> 491
<212> DNA
<213> Rattus norvegicus
<308> AA859919
<400> 5024

ttttttttt  tttttttca  tattagcca  acctttagg  ctgttatat  ttaaagcaa  60
ccaatatag  tacaacaga  ttgcaggag  cttagaata  cagagccat  tgtcggggg  120
catcaggga  aatactgat  gtatcttcg  ctttgccac  caacagaca  agcatggta  180
attcctgaa  ttcatccat  atgctgaat  tatactcat  tctggctat  acatgatga  240
aattcttac  caaatggtc  taggtaact  tttcttctc  atcttcctc  ttcagggat  300
tgtttgtga  cagcataaa  tcccgctta  tgcacacgg  gcatcctgc  aagttcagt  360
agaacgagc  attctccag  caggtgttc  ccttatttg  atggaaaat  ctgcatccc  420
attcctgat  agtcttcct  ttcacatcg  ttaaatagc  ctctgtcaa  catacttcc  480
aaactgcaa  t  491



<210> 5025
<211> 459
<212> DNA
<213> Homo sapiens
<308> AV699259
<400> 5025

ctcgtgccg  attcggcac  agctgatca  aaacaaatc  ttgaaagaa  aagatggag  60
agaaatagt  acctatgat  gagtatacc  tgctgtgtc  gttatgcgg  aaagccgaa  120
atactatca  tattctccc  gatgacccc  gacaaatga  tctcttatt  taaggatcc  180
tctacagat  tgttataac  atattgtgt  ggtttacaa  acagcaagc  tgatggttt  240
tcttatttc  ttcataaaa  aaaaaaaaa  aaactcgag  ttttttttt  tttttttga  300
caaaggtat  ttaatatat  gattctttg  aaatgagaa  tgagacatg  gctaaaatt  360
aatacatca  caacaaaaa  cttgtaagg  gaagttaaa  gcagttatt  caaggataa  420
ggatatttg  ttcattttg  acctgatat  cattacttt  459



<210> 5026
<211> 491
<212> DNA
<213> Rattus norvegicus
<308> AA859919
<400> 5026

ttttttttt  tttttttca  tattagcca  acctttagg  ctgttatat  ttaaagcaa  60
ccaatatag  tacaacaga  ttgcaggag  cttagaata  cagagccat  tgtcggggg  120
catcaggga  aatactgat  gtatcttcg  ctttgccac  caacagaca  agcatggta  180
attcctgaa  ttcatccat  atgctgaat  tatactcat  tctggctat  acatgatga  240
aattcttac  caaatggtc  taggtaact  tttcttctc  atcttcctc  ttcagggat  300
tgtttgtga  cagcataaa  tcccgctta  tgcacacgg  gcatcctgc  aagttcagt  360
agaacgagc  attctccag  caggtgttc  ccttatttg  atggaaaat  ctgcatccc  420
attcctgat  agtcttcct  ttcacatcg  ttaaatagc  ctctgtcaa  catacttcc  480
aaactgcaa  t  491



<210> 5027
<211> 459
<212> DNA
<213> Homo sapiens
<308> AV699259
<400> 5027

ctcgtgccg  attcggcac  agctgatca  aaacaaatc  ttgaaagaa  aagatggag  60
agaaatagt  acctatgat  gagtatacc  tgctgtgtc  gttatgcgg  aaagccgaa  120
atactatca  tattctccc  gatgacccc  gacaaatga  tctcttatt  taaggatcc  180
tctacagat  tgttataac  atattgtgt  ggtttacaa  acagcaagc  tgatggttt  240
tcttatttc  ttcataaaa  aaaaaaaaa  aaactcgag  ttttttttt  tttttttga  300
caaaggtat  ttaatatat  gattctttg  aaatgagaa  tgagacatg  gctaaaatt  360
aatacatca  caacaaaaa  cttgtaagg  gaagttaaa  gcagttatt  caaggataa  420
ggatatttg  ttcattttg  acctgatat  cattacttt  459



<210> 5028
<211> 331
<212> DNA
<213> Rattus norvegicus
<308> AA859921
<400> 5028

ttttttttt  tttttttgt  tttccaagt  gcattaatt  aaagcggta  ccaacaagc  60
gctcgagca  atggccatc  gcgaatgct  cccgtggct  ggtgcagct  cgagtgggg  120
ccagcagca  ggtggagag  gggacgagg  atttggcta  cttaagaga  tcatagtta  180
tcccgccgt  tacccgcgc  tcattgaat  tcttcacta  gacattcag  gcactgggc  240
gaaatcaca  cgcgtcaac  cccgccgcg  gccttcgcg  tgctttgtt  taattaaac  300
gtcggattc  cctggtccg  accagttct  a  331



<210> 5029
<211> 523
<212> DNA
<213> Rattus norvegicus
<308> AA859931
<400> 5029

ttttttttt  tttttttcc  ttttaacaa  agtctttat  gataacttc  caacatctg  60
aaacatcag  tataaaaat  ttccattca  ctgttttct  aggtgactg  ccagctcct  120
gagataacc  gatggacct  ggagaaaca  agctcctca  agtcaaggc  gcctcttcc  180
ccagaattc  acacaacag  aaaaaagta  tccacagag  gaaaggaga  atagttgaa  240
cagcagctg  cagtgggta  gaacaagct  atccctcct  tgcccaccc  gggtgtggg  300
gatgacaat  tggctttgg  ctctggaga  cttagaagc  ctgttcaaa  ctggcccag  360
ctgatttca  ggttacctc  acccatccc  actgcccca  ctagacata  atgctggca  420
acgaagtcc  gctcttacg  ggagtggca  gaattanga  ccctgccta  aaaagaaag  480
agcagcaaa  ctgactgac  gttacccta  gagaaccac  gct  523



<210> 5030
<211> 1444
<212> DNA
<213> Homo sapiens
<308> BC001080
<400> 5030

ggcacgagg  cgcacgcaa  cggctccag  gtacgtccc  gccacgcgc  ctcgcagga  60
cggtgcgtg  tgacgtttc  ccggcgcgg  cgccatccc  gaagcgcga  caaggccgc  120
agatgtgca  gcagcggag  aggagaaag  gatggacct  ccggactcg  cctcgaggg  180
cttctgcgg  cgcatcctg  gcatggtga  cacagatga  gtcaacgcc  tcatcctgg  240
ccagaagaa  atgctggac  gctttgaga  gaccaatga  atgctgctc  acttcaaca  300
cctgtccag  gcccgcctg  agcagatga  cgaacgctt  ctgcaccac  cgaggaccc  360
agtagagat  aaacgggac  tggacagca  cttccgccg  atcaggacg  tgaaaggga  420
actggccag  cagcaccca  aggccttca  ccatatccc  gaggcatcc  tcctggagg  480
agaggatga  gaccccatc  cacccagca  cacgaccac  attgccacc  cagaacaga  540
cacgggctc  tgtgacacc  gccccgaca  cgtctcgcc  tccctgagc  ccggcttcg  600
ggacctgtc  catgtccag  ctggctccc  agccatcaa  ggccgcagc  agacagatg  660
cgaggagat  acgggcgaa  agccctgct  cccggtgcc  tgagggggt  tcagggcag  720
agcatacaa  gtggcagcg  gtaaccctg  cttgttctg  catccaggg  tcctttgct  780
ccccgttct  tcacccagg  ctcctaggg  gacaaggct  tctcccgag  ggtgtggaa  840
tcctggggg  gtctttaat  ctggctcct  ccttcctca  aacatctct  ttctgcaag  900
cccctctgc  atgccaggg  acgcccatt  cagctggag  cgtggggct  ggcacaggg  960
aatttttcc  gagctgagc  tgacgtctg  tctgaagaa  gcttagaag  ttcccagac  1020
ccagagcca  atgtccccc  ccaccggtc  ggacctcct  gaggtgcac  agcacggtc  1080
cctctgagt  caccccagc  cacccccgc  cccactaat  ctgcttttc  tgccccttg  1140
tccgtaaaa  tatcaaata  tttctcctt  gtatctcaa  gaggtttct  agataggta  1200
aagtcttga  acggaggct  gccatccat  cagccctga  cgtgctgag  tctgtgttt  1260
tctgaatag  ggtgtggaa  ctgaggggc  agcaggcct  tctgaaggc  tccatggag  1320
aaacggagc  acctcggga  agagtttaa  ggaatattt  tgtacccga  gtttacaga  1380
gctgttggg  agttatcaa  aaaaagaca  cattactaa  aagggaaaa  aaaaaaaaa  1440
aaaa  1444



<210> 5031
<211> 177
<212> PRT
<213> Homo sapiens
<308> BC001080
<400> 5031

Met Asp Leu Pro Asp Ser Ala Ser Arg Val Phe Cys Gly Arg Ile Leu 
  1               5                  10                  15
Ser Met Val Asn Thr Asp Asp Val Asn Ala Ile Ile Leu Ala Gln Lys 
             20                  25                  30
Asn Met Leu Asp Arg Phe Glu Lys Thr Asn Glu Met Leu Leu Asn Phe 
         35                  40                  45
Asn Asn Leu Ser Ser Ala Arg Leu Gln Gln Met Ser Glu Arg Phe Leu 
     50                  55                  60
His His Thr Arg Thr Leu Val Glu Met Lys Arg Asp Leu Asp Ser Ile 
 65                  70                  75                  80
Phe Arg Arg Ile Arg Thr Leu Lys Gly Lys Leu Ala Arg Gln His Pro 
                 85                  90                  95
Glu Ala Phe Ser His Ile Pro Glu Ala Ser Phe Leu Glu Glu Glu Asp 
             100                105                110
Glu Asp Pro Ile Pro Pro Ser Thr Thr Thr Thr Ile Ala Thr Ser Glu 
         115                120                125
Gln Ser Thr Gly Ser Cys Asp Thr Ser Pro Asp Thr Val Ser Pro Ser 
     130                135                140
Leu Ser Pro Gly Phe Glu Asp Leu Ser His Val Gln Ala Gly Ser Pro 
 145                150                155                160
Ala Ile Asn Gly Arg Ser Gln Thr Asp Asp Glu Glu Met Thr Gly Glu 
                 165                170                175
Ter 
             180



<210> 5032
<211> 523
<212> DNA
<213> Rattus norvegicus
<308> AA859931
<400> 5032

ttttttttt  tttttttcc  ttttaacaa  agtctttat  gataacttc  caacatctg  60
aaacatcag  tataaaaat  ttccattca  ctgttttct  aggtgactg  ccagctcct  120
gagataacc  gatggacct  ggagaaaca  agctcctca  agtcaaggc  gcctcttcc  180
ccagaattc  acacaacag  aaaaaagta  tccacagag  gaaaggaga  atagttgaa  240
cagcagctg  cagtgggta  gaacaagct  atccctcct  tgcccaccc  gggtgtggg  300
gatgacaat  tggctttgg  ctctggaga  cttagaagc  ctgttcaaa  ctggcccag  360
ctgatttca  ggttacctc  acccatccc  actgcccca  ctagacata  atgctggca  420
acgaagtcc  gctcttacg  ggagtggca  gaattanga  ccctgccta  aaaagaaag  480
agcagcaaa  ctgactgac  gttacccta  gagaaccac  gct  523



<210> 5033
<211> 1444
<212> DNA
<213> Homo sapiens
<308> BC001080
<400> 5033

ggcacgagg  cgcacgcaa  cggctccag  gtacgtccc  gccacgcgc  ctcgcagga  60
cggtgcgtg  tgacgtttc  ccggcgcgg  cgccatccc  gaagcgcga  caaggccgc  120
agatgtgca  gcagcggag  aggagaaag  gatggacct  ccggactcg  cctcgaggg  180
cttctgcgg  cgcatcctg  gcatggtga  cacagatga  gtcaacgcc  tcatcctgg  240
ccagaagaa  atgctggac  gctttgaga  gaccaatga  atgctgctc  acttcaaca  300
cctgtccag  gcccgcctg  agcagatga  cgaacgctt  ctgcaccac  cgaggaccc  360
agtagagat  aaacgggac  tggacagca  cttccgccg  atcaggacg  tgaaaggga  420
actggccag  cagcaccca  aggccttca  ccatatccc  gaggcatcc  tcctggagg  480
agaggatga  gaccccatc  cacccagca  cacgaccac  attgccacc  cagaacaga  540
cacgggctc  tgtgacacc  gccccgaca  cgtctcgcc  tccctgagc  ccggcttcg  600
ggacctgtc  catgtccag  ctggctccc  agccatcaa  ggccgcagc  agacagatg  660
cgaggagat  acgggcgaa  agccctgct  cccggtgcc  tgagggggt  tcagggcag  720
agcatacaa  gtggcagcg  gtaaccctg  cttgttctg  catccaggg  tcctttgct  780
ccccgttct  tcacccagg  ctcctaggg  gacaaggct  tctcccgag  ggtgtggaa  840
tcctggggg  gtctttaat  ctggctcct  ccttcctca  aacatctct  ttctgcaag  900
cccctctgc  atgccaggg  acgcccatt  cagctggag  cgtggggct  ggcacaggg  960
aatttttcc  gagctgagc  tgacgtctg  tctgaagaa  gcttagaag  ttcccagac  1020
ccagagcca  atgtccccc  ccaccggtc  ggacctcct  gaggtgcac  agcacggtc  1080
cctctgagt  caccccagc  cacccccgc  cccactaat  ctgcttttc  tgccccttg  1140
tccgtaaaa  tatcaaata  tttctcctt  gtatctcaa  gaggtttct  agataggta  1200
aagtcttga  acggaggct  gccatccat  cagccctga  cgtgctgag  tctgtgttt  1260
tctgaatag  ggtgtggaa  ctgaggggc  agcaggcct  tctgaaggc  tccatggag  1320
aaacggagc  acctcggga  agagtttaa  ggaatattt  tgtacccga  gtttacaga  1380
gctgttggg  agttatcaa  aaaaagaca  cattactaa  aagggaaaa  aaaaaaaaa  1440
aaaa  1444



<210> 5034
<211> 177
<212> PRT
<213> Homo sapiens
<308> BC001080
<400> 5034

Met Asp Leu Pro Asp Ser Ala Ser Arg Val Phe Cys Gly Arg Ile Leu 
  1               5                  10                  15
Ser Met Val Asn Thr Asp Asp Val Asn Ala Ile Ile Leu Ala Gln Lys 
             20                  25                  30
Asn Met Leu Asp Arg Phe Glu Lys Thr Asn Glu Met Leu Leu Asn Phe 
         35                  40                  45
Asn Asn Leu Ser Ser Ala Arg Leu Gln Gln Met Ser Glu Arg Phe Leu 
     50                  55                  60
His His Thr Arg Thr Leu Val Glu Met Lys Arg Asp Leu Asp Ser Ile 
 65                  70                  75                  80
Phe Arg Arg Ile Arg Thr Leu Lys Gly Lys Leu Ala Arg Gln His Pro 
                 85                  90                  95
Glu Ala Phe Ser His Ile Pro Glu Ala Ser Phe Leu Glu Glu Glu Asp 
             100                105                110
Glu Asp Pro Ile Pro Pro Ser Thr Thr Thr Thr Ile Ala Thr Ser Glu 
         115                120                125
Gln Ser Thr Gly Ser Cys Asp Thr Ser Pro Asp Thr Val Ser Pro Ser 
     130                135                140
Leu Ser Pro Gly Phe Glu Asp Leu Ser His Val Gln Ala Gly Ser Pro 
 145                150                155                160
Ala Ile Asn Gly Arg Ser Gln Thr Asp Asp Glu Glu Met Thr Gly Glu 
                 165                170                175
Ter 
             180



<210> 5035
<211> 534
<212> DNA
<213> Rattus norvegicus
<308> AA859933
<400> 5035

ttttttttt  tttttttgc  ccaattcaa  tttggtttt  ttagaaatc  caccataat  60
agattttta  agactggat  gttgccttg  aacttttcc  ttcccattt  gaaagataa  120
tagaagcaa  gacaaaaat  accacttaa  ataggggat  cttcccccg  gtttcttgt  180
agcgtaagt  caggcattc  actcttcca  tcagaaaag  aaaataaaa  gctttggag  240
acaccaacc  ttactcaga  ggacaaaac  tctgcctcc  gttctcacg  tagaccagg  300
cgcatatcc  gagtggctg  tctccatcc  gcccatgct  gctaaagca  ccgagtaaa  360
cccaaggtc  gtcccaacc  caaccttca  cagtatgaa  tgcttacac  tcttatgac  420
caagccatg  ttcggcgga  gggtcgggt  agacacccc  catctcccg  gggtgaatc  480
caacagcag  catgtttgt  ttctcttcc  tacagttca  tgtgcaaag  catt  534



<210> 5036
<211> 534
<212> DNA
<213> Rattus norvegicus
<308> AA859933
<400> 5036

ttttttttt  tttttttgc  ccaattcaa  tttggtttt  ttagaaatc  caccataat  60
agattttta  agactggat  gttgccttg  aacttttcc  ttcccattt  gaaagataa  120
tagaagcaa  gacaaaaat  accacttaa  ataggggat  cttcccccg  gtttcttgt  180
agcgtaagt  caggcattc  actcttcca  tcagaaaag  aaaataaaa  gctttggag  240
acaccaacc  ttactcaga  ggacaaaac  tctgcctcc  gttctcacg  tagaccagg  300
cgcatatcc  gagtggctg  tctccatcc  gcccatgct  gctaaagca  ccgagtaaa  360
cccaaggtc  gtcccaacc  caaccttca  cagtatgaa  tgcttacac  tcttatgac  420
caagccatg  ttcggcgga  gggtcgggt  agacacccc  catctcccg  gggtgaatc  480
caacagcag  catgtttgt  ttctcttcc  tacagttca  tgtgcaaag  catt  534



<210> 5037
<211> 534
<212> DNA
<213> Rattus norvegicus
<308> AA859933
<400> 5037

ttttttttt  tttttttgc  ccaattcaa  tttggtttt  ttagaaatc  caccataat  60
agattttta  agactggat  gttgccttg  aacttttcc  ttcccattt  gaaagataa  120
tagaagcaa  gacaaaaat  accacttaa  ataggggat  cttcccccg  gtttcttgt  180
agcgtaagt  caggcattc  actcttcca  tcagaaaag  aaaataaaa  gctttggag  240
acaccaacc  ttactcaga  ggacaaaac  tctgcctcc  gttctcacg  tagaccagg  300
cgcatatcc  gagtggctg  tctccatcc  gcccatgct  gctaaagca  ccgagtaaa  360
cccaaggtc  gtcccaacc  caaccttca  cagtatgaa  tgcttacac  tcttatgac  420
caagccatg  ttcggcgga  gggtcgggt  agacacccc  catctcccg  gggtgaatc  480
caacagcag  catgtttgt  ttctcttcc  tacagttca  tgtgcaaag  catt  534



<210> 5038
<211> 534
<212> DNA
<213> Rattus norvegicus
<308> AA859933
<400> 5038

ttttttttt  tttttttgc  ccaattcaa  tttggtttt  ttagaaatc  caccataat  60
agattttta  agactggat  gttgccttg  aacttttcc  ttcccattt  gaaagataa  120
tagaagcaa  gacaaaaat  accacttaa  ataggggat  cttcccccg  gtttcttgt  180
agcgtaagt  caggcattc  actcttcca  tcagaaaag  aaaataaaa  gctttggag  240
acaccaacc  ttactcaga  ggacaaaac  tctgcctcc  gttctcacg  tagaccagg  300
cgcatatcc  gagtggctg  tctccatcc  gcccatgct  gctaaagca  ccgagtaaa  360
cccaaggtc  gtcccaacc  caaccttca  cagtatgaa  tgcttacac  tcttatgac  420
caagccatg  ttcggcgga  gggtcgggt  agacacccc  catctcccg  gggtgaatc  480
caacagcag  catgtttgt  ttctcttcc  tacagttca  tgtgcaaag  catt  534



<210> 5039
<211> 436
<212> DNA
<213> Rattus norvegicus
<308> AA859937
<400> 5039

atttttttt  tttttttgc  ttgcaagtc  cacatttta  tacaaattt  ttttgcgcc  60
agtagaaaa  caaattctg  atctattta  aagcactat  tatttacat  tattatata  120
aattaatga  tctaaagaa  gttggagga  aaacgatat  tttggggga  tatgccact  180
tacagggtt  catgttctt  aatgtcact  tatccttcc  gtagtaata  atacaattc  240
ctatgtaca  atcttataa  acatctcat  aatgtattt  ttaaaaaat  ccacattaa  300
acatctggt  aaaataaaa  atgcttata  aaaaataaa  ctacctgat  gccttttgg  360
ttgggtgca  tgaggctaa  gtatgacca  agaagttta  aataaactt  tcacttttc  420
aatttaata  tttgtc  436



<210> 5040
<211> 401
<212> DNA
<213> Homo sapiens
<308> AI581056
<400> 5040

tttttgttt  atagtcaca  attttatta  aaatttatt  tttacccaa  agaaaagca  60
atttggaat  tatttacaa  tactatata  ttacatata  acagttaat  aatttaaag  120
aaatgggca  agaaacaca  tataaatca  agaatatgc  actgtacaa  gtttattat  180
attatcatg  tccttaatg  tactgaacc  ttactatag  aataaatac  gttctatat  240
tacacatct  ataaaacat  tcataaatg  attttttca  atccaagtt  aaacatctg  300
tcaaaataa  catgcttat  taaaaataa  tctacctaa  agccatttg  ttttgatgt  360
tgaagctaa  ataggataa  agaagggag  attaatact  t  401



<210> 5041
<211> 907
<212> PRT
<213> Homo sapiens
<308> O75473
<400> 5041

Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu 
  1               5                  10                  15
Gln Leu Ala Thr Gly Gly Ser Ser Pro Arg Ser Gly Val Leu Leu Arg 
             20                  25                  30
Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu 
         35                  40                  45
Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu 
     50                  55                  60
Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln 
 65                  70                  75                  80
Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg 
                 85                  90                  95
Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly 
             100                105                110
Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg His 
         115                120                125
Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg 
     130                135                140
Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly 
 145                150                155                160
Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                 165                170                175
Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr 
             180                185                190
Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn 
         195                200                205
Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser 
     210                215                220
Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp 
 225                230                235                240
Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu 
                 245                250                255
Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile 
             260                265                270
Pro Glu Lys Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe 
         275                280                285
Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln His Leu 
     290                295                300
Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser Gln Ile Thr Glu 
 305                310                315                320
Phe Pro Asp Leu Thr Gly Thr Ala Asn Leu Glu Ser Leu Thr Leu Thr 
                 325                330                335
Gly Ala Gln Ile Ser Ser Leu Pro Gln Thr Val Cys Asn Gln Leu Pro 
             340                345                350
Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro 
         355                360                365
Ser Phe Ser Val Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn 
     370                375                380
Glu Ile Tyr Glu Ile Lys Val Asp Thr Phe Gln Gln Leu Leu Ser Leu 
 385                390                395                400
Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn 
                 405                410                415
Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn 
             420                425                430
Leu Leu Ser Ser Phe Pro Ile Thr Gly Leu His Gly Leu Thr His Leu 
         435                440                445
Lys Leu Thr Gly Asn His Ala Leu Gln Ser Leu Ile Ser Ser Glu Asn 
     450                455                460
Phe Pro Glu Leu Lys Val Ile Glu Met Pro Tyr Ala Tyr Gln Cys Cys 
 465                470                475                480
Ala Phe Gly Val Cys Glu Asn Ala Tyr Lys Ile Ser Asn Gln Trp Asn 
                 485                490                495
Lys Gly Asp Asn Ser Ser Met Asp Asp Leu His Lys Lys Asp Ala Gly 
             500                505                510
Met Phe Gln Ala Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp 
         515                520                525
Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser 
     530                535                540
Pro Gly Pro Phe Lys Pro Cys Glu His Leu Leu Asp Gly Trp Leu Ile 
 545                550                555                560
Arg Ile Gly Val Trp Thr Ile Ala Val Leu Ala Leu Thr Cys Asn Ala 
                 565                570                575
Leu Val Thr Ser Thr Val Phe Arg Ser Pro Leu Tyr Ile Ser Pro Ile 
             580                585                590
Lys Leu Leu Ile Gly Val Ile Ala Ala Val Asn Met Leu Thr Gly Val 
         595                600                605
Ser Ser Ala Val Leu Ala Gly Val Asp Ala Phe Thr Phe Gly Ser Phe 
     610                615                620
Ala Arg His Gly Ala Trp Trp Glu Asn Gly Val Gly Cys His Val Ile 
 625                630                635                640
Gly Phe Leu Ser Ile Phe Ala Ser Glu Ser Ser Val Phe Leu Leu Thr 
                 645                650                655
Leu Ala Ala Leu Glu Arg Gly Phe Ser Val Lys Tyr Ser Ala Lys Phe 
             660                665                670
Glu Thr Lys Ala Pro Phe Ser Ser Leu Lys Val Ile Ile Leu Leu Cys 
         675                680                685
Ala Leu Leu Ala Leu Thr Met Ala Ala Val Pro Leu Leu Gly Gly Ser 
     690                695                700
Lys Tyr Gly Ala Ser Pro Leu Cys Leu Pro Leu Pro Phe Gly Glu Pro 
 705                710                715                720
Ser Thr Met Gly Tyr Met Val Ala Leu Ile Leu Leu Asn Ser Leu Cys 
                 725                730                735
Phe Leu Met Met Thr Ile Ala Tyr Thr Lys Leu Tyr Cys Asn Leu Asp 
             740                745                750
Lys Gly Asp Leu Glu Asn Ile Trp Asp Cys Ser Met Val Lys His Ile 
         755                760                765
Ala Leu Leu Leu Phe Thr Asn Cys Ile Leu Asn Cys Pro Val Ala Phe 
     770                775                780
Leu Ser Phe Ser Ser Leu Ile Asn Leu Thr Phe Ile Ser Pro Glu Val 
 785                790                795                800
Ile Lys Phe Ile Leu Leu Val Val Val Pro Leu Pro Ala Cys Leu Asn 
                 805                810                815
Pro Leu Leu Tyr Ile Leu Phe Asn Pro His Phe Lys Glu Asp Leu Val 
             820                825                830
Ser Leu Arg Lys Gln Thr Tyr Val Trp Thr Arg Ser Lys His Pro Ser 
         835                840                845
Leu Met Ser Ile Asn Ser Asp Asp Val Glu Lys Gln Ser Cys Asp Ser 
     850                855                860
Thr Gln Ala Leu Val Thr Phe Thr Ser Ser Ser Ile Thr Tyr Asp Leu 
 865                870                875                880
Pro Pro Ser Ser Val Pro Ser Pro Ala Tyr Pro Val Thr Glu Ser Cys 
                 885                890                895
His Leu Ser Ser Val Ala Phe Val Pro Cys Leu 
             900                905



<210> 5042
<211> 436
<212> DNA
<213> Rattus norvegicus
<308> AA859937
<400> 5042

atttttttt  tttttttgc  ttgcaagtc  cacatttta  tacaaattt  ttttgcgcc  60
agtagaaaa  caaattctg  atctattta  aagcactat  tatttacat  tattatata  120
aattaatga  tctaaagaa  gttggagga  aaacgatat  tttggggga  tatgccact  180
tacagggtt  catgttctt  aatgtcact  tatccttcc  gtagtaata  atacaattc  240
ctatgtaca  atcttataa  acatctcat  aatgtattt  ttaaaaaat  ccacattaa  300
acatctggt  aaaataaaa  atgcttata  aaaaataaa  ctacctgat  gccttttgg  360
ttgggtgca  tgaggctaa  gtatgacca  agaagttta  aataaactt  tcacttttc  420
aatttaata  tttgtc  436



<210> 5043
<211> 401
<212> DNA
<213> Homo sapiens
<308> AI581056
<400> 5043

tttttgttt  atagtcaca  attttatta  aaatttatt  tttacccaa  agaaaagca  60
atttggaat  tatttacaa  tactatata  ttacatata  acagttaat  aatttaaag  120
aaatgggca  agaaacaca  tataaatca  agaatatgc  actgtacaa  gtttattat  180
attatcatg  tccttaatg  tactgaacc  ttactatag  aataaatac  gttctatat  240
tacacatct  ataaaacat  tcataaatg  attttttca  atccaagtt  aaacatctg  300
tcaaaataa  catgcttat  taaaaataa  tctacctaa  agccatttg  ttttgatgt  360
tgaagctaa  ataggataa  agaagggag  attaatact  t  401



<210> 5044
<211> 907
<212> PRT
<213> Homo sapiens
<308> O75473
<400> 5044

Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu 
  1               5                  10                  15
Gln Leu Ala Thr Gly Gly Ser Ser Pro Arg Ser Gly Val Leu Leu Arg 
             20                  25                  30
Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu 
         35                  40                  45
Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu 
     50                  55                  60
Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln 
 65                  70                  75                  80
Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg 
                 85                  90                  95
Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly 
             100                105                110
Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg His 
         115                120                125
Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg 
     130                135                140
Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly 
 145                150                155                160
Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                 165                170                175
Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr 
             180                185                190
Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn 
         195                200                205
Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser 
     210                215                220
Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp 
 225                230                235                240
Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu 
                 245                250                255
Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile 
             260                265                270
Pro Glu Lys Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe 
         275                280                285
Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln His Leu 
     290                295                300
Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser Gln Ile Thr Glu 
 305                310                315                320
Phe Pro Asp Leu Thr Gly Thr Ala Asn Leu Glu Ser Leu Thr Leu Thr 
                 325                330                335
Gly Ala Gln Ile Ser Ser Leu Pro Gln Thr Val Cys Asn Gln Leu Pro 
             340                345                350
Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro 
         355                360                365
Ser Phe Ser Val Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn 
     370                375                380
Glu Ile Tyr Glu Ile Lys Val Asp Thr Phe Gln Gln Leu Leu Ser Leu 
 385                390                395                400
Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn 
                 405                410                415
Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn 
             420                425                430
Leu Leu Ser Ser Phe Pro Ile Thr Gly Leu His Gly Leu Thr His Leu 
         435                440                445
Lys Leu Thr Gly Asn His Ala Leu Gln Ser Leu Ile Ser Ser Glu Asn 
     450                455                460
Phe Pro Glu Leu Lys Val Ile Glu Met Pro Tyr Ala Tyr Gln Cys Cys 
 465                470                475                480
Ala Phe Gly Val Cys Glu Asn Ala Tyr Lys Ile Ser Asn Gln Trp Asn 
                 485                490                495
Lys Gly Asp Asn Ser Ser Met Asp Asp Leu His Lys Lys Asp Ala Gly 
             500                505                510
Met Phe Gln Ala Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp 
         515                520                525
Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser 
     530                535                540
Pro Gly Pro Phe Lys Pro Cys Glu His Leu Leu Asp Gly Trp Leu Ile 
 545                550                555                560
Arg Ile Gly Val Trp Thr Ile Ala Val Leu Ala Leu Thr Cys Asn Ala 
                 565                570                575
Leu Val Thr Ser Thr Val Phe Arg Ser Pro Leu Tyr Ile Ser Pro Ile 
             580                585                590
Lys Leu Leu Ile Gly Val Ile Ala Ala Val Asn Met Leu Thr Gly Val 
         595                600                605
Ser Ser Ala Val Leu Ala Gly Val Asp Ala Phe Thr Phe Gly Ser Phe 
     610                615                620
Ala Arg His Gly Ala Trp Trp Glu Asn Gly Val Gly Cys His Val Ile 
 625                630                635                640
Gly Phe Leu Ser Ile Phe Ala Ser Glu Ser Ser Val Phe Leu Leu Thr 
                 645                650                655
Leu Ala Ala Leu Glu Arg Gly Phe Ser Val Lys Tyr Ser Ala Lys Phe 
             660                665                670
Glu Thr Lys Ala Pro Phe Ser Ser Leu Lys Val Ile Ile Leu Leu Cys 
         675                680                685
Ala Leu Leu Ala Leu Thr Met Ala Ala Val Pro Leu Leu Gly Gly Ser 
     690                695                700
Lys Tyr Gly Ala Ser Pro Leu Cys Leu Pro Leu Pro Phe Gly Glu Pro 
 705                710                715                720
Ser Thr Met Gly Tyr Met Val Ala Leu Ile Leu Leu Asn Ser Leu Cys 
                 725                730                735
Phe Leu Met Met Thr Ile Ala Tyr Thr Lys Leu Tyr Cys Asn Leu Asp 
             740                745                750
Lys Gly Asp Leu Glu Asn Ile Trp Asp Cys Ser Met Val Lys His Ile 
         755                760                765
Ala Leu Leu Leu Phe Thr Asn Cys Ile Leu Asn Cys Pro Val Ala Phe 
     770                775                780
Leu Ser Phe Ser Ser Leu Ile Asn Leu Thr Phe Ile Ser Pro Glu Val 
 785                790                795                800
Ile Lys Phe Ile Leu Leu Val Val Val Pro Leu Pro Ala Cys Leu Asn 
                 805                810                815
Pro Leu Leu Tyr Ile Leu Phe Asn Pro His Phe Lys Glu Asp Leu Val 
             820                825                830
Ser Leu Arg Lys Gln Thr Tyr Val Trp Thr Arg Ser Lys His Pro Ser 
         835                840                845
Leu Met Ser Ile Asn Ser Asp Asp Val Glu Lys Gln Ser Cys Asp Ser 
     850                855                860
Thr Gln Ala Leu Val Thr Phe Thr Ser Ser Ser Ile Thr Tyr Asp Leu 
 865                870                875                880
Pro Pro Ser Ser Val Pro Ser Pro Ala Tyr Pro Val Thr Glu Ser Cys 
                 885                890                895
His Leu Ser Ser Val Ala Phe Val Pro Cys Leu 
             900                905



<210> 5045
<211> 479
<212> DNA
<213> Rattus norvegicus
<308> AA859951
<400> 5045

ttttttttt  tttttttca  tgtcaaaaa  attacttta  ttttttagg  tgaaatgtc  60
tatcacgta  aaaaaaatt  tttagaatt  gctacaatt  gttaaaaac  tagcaatct  120
ttgcctaca  gtaggaaag  tcttgctgg  acaagctta  gtgattaag  ccatatata  180
ttagatata  aaatagatg  taaggacag  aatactggg  cggggagat  cagaatccc  240
ttaaatcat  aggatgtag  attcttgca  cagcacaat  cttacaaca  gggacattt  300
tccttttgt  aactaaaag  acagaacag  ctgtattta  ctacttcca  cttaatagc  360
taagcaaat  tttgtgacc  tactgagca  ctaagtctc  ttagttgta  gcataggct  420
aagtgacat  ttatgtaca  agggaggag  agggcttcg  cagaacctg  acacctgag  479



<210> 5046
<211> 305
<212> DNA
<213> Homo sapiens
<308> R40468
<400> 5046

ttttttttt  ttttttttt  ttttcaatg  caaaaacat  actttattt  tctaggatg  60
aatgtccta  tacgtacaa  aganttgct  tttagantt  gccacaatt  gttaaaaac  120
tagcaatct  ttgcctaca  gtnggaaag  tcttgctgc  acaaatttt  aatgattan  180
cccatatat  tttatatat  tggantaaa  nggtacagg  antactgtg  ngtgatggg  240
atggcagga  taattttat  nttcattaa  ntgtgggat  tcttgncat  agcacagng  300
catac  305



<210> 5047
<211> 460
<212> DNA
<213> Rattus norvegicus
<308> AA859952
<400> 5047

ttttttttt  tttttttaa  ttttattta  aaaaccttc  gtgcaatat  aaaaagcaa  60
acagccagg  ggaacagtc  acagacaga  agggaagga  ctagaggac  caaggtcct  120
tacctcacc  gttccccag  agctggggg  caaggggga  ggtctgggg  tggtgggac  180
aggaaaaac  accacatcc  tgactgtcc  ctccactgg  tccgttggc  tctccttgc  240
cccaggagg  cagccaaat  gtgtcccat  agccccagg  agggctggt  ttcctggag  300
caaaggcac  ggagatgga  aatctggag  agctgtaac  caagccgat  ccccttctt  360
attcatagc  gtcatcgag  acacctggt  tgtgcagct  ccaggtgct  gtccccgcc  420
ttcatcctg  ccctggaaa  gtccacagg  cgaccactcc  460



<210> 5048
<211> 991
<212> DNA
<213> Homo sapiens
<308> BC007384
<400> 5048

ggcacgagg  ccggacggg  gccgccggc  gccagcgcc  gcccgtctc  cagcaagag  60
ggtggagaa  agcgagtac  tgagaaaga  gaggaagaa  atgatgatg  agatgaaga  120
gaggaagat  atgtgtcag  gggctctga  gtgcccgag  gtgaccgtc  tgcaggtgc  180
cagcaccac  agcttaacg  cgagcgggg  cctcagagt  ccaaggaga  ggtcaagga  240
tggaccccc  gcggaccgc  ccagggcca  gatgaaggg  gggggccag  cccgggcag  300
ggcacccgc  aggtgttct  catggcagc  atgaacaag  aagggggaa  agcttctgt  360
gccaccggg  cagactccc  gtcccccgt  cctttgccc  caggcaaac  agccctacc  420
ggggccgac  ggaccccct  tggctgtcc  cccgggcgc  aagagaagc  atctgatcc  480
gtcgagtgg  ccgtgatgg  tgtcgtcga  tattttact  aggctggat  cccggagca  540
gcgacagct  tccaagagc  ggaaattga  ggcaaatct  tgctgctca  gcagcgcac  600
gatgtgctc  ccggcctgt  catccgcct  gggccagcc  tgaaaatct  cgagcacca  660
atcaaggtg  ttcagcaag  ccactttga  gatgatgac  ccgatggct  cttaggctg  720
gcgcccagc  tcacccctg  cccagccca  tccggcccc  atctcaccc  agatccccc  780
gagtccagg  gctggacgg  gacaccctc  gccctcata  cagattcca  ggagagggc  840
ccctcttgt  cttatcttt  ccccttgtg  ctgtctcac  cacatctgc  cctcagcac  900
tcggtgtgg  gaggggatt  ctccttaaa  cccaggtgg  tgaccctcc  cacccagtc  960
aggacattt  aggaaaaaa  aaaaaaaaa  a  991



<210> 5049
<211> 132
<212> PRT
<213> Homo sapiens
<308> XP_031299
<400> 5049

Met Ala Ala Met Asn Lys Glu Gly Gly Thr Ala Ser Val Ala Thr Gly 
  1               5                  10                  15
Pro Asp Ser Pro Ser Pro Val Pro Leu Pro Pro Gly Lys Pro Ala Leu 
             20                  25                  30
Pro Gly Ala Asp Gly Thr Pro Phe Gly Cys Pro Pro Gly Arg Lys Glu 
         35                  40                  45
Lys Pro Ser Asp Pro Val Glu Trp Thr Val Met Asp Val Val Glu Tyr 
     50                  55                  60
Phe Thr Glu Ala Gly Phe Pro Glu Gln Ala Thr Ala Phe Gln Glu Gln 
 65                  70                  75                  80
Glu Ile Asp Gly Lys Ser Leu Leu Leu Met Gln Arg Thr Asp Val Leu 
                 85                  90                  95
Thr Gly Leu Ser Ile Arg Leu Gly Pro Ala Leu Lys Ile Tyr Glu His 
             100                105                110
His Ile Lys Val Leu Gln Gln Gly His Phe Glu Asp Asp Asp Pro Asp 
         115                120                125
Gly Phe Leu Gly 
     130



<210> 5050
<211> 536
<212> DNA
<213> Rattus norvegicus
<308> AA859954
<400> 5050

ttttttttt  tttttttgg  atgatcaaa  atgtcttta  aaagttttt  acgacttca  60
tctaaatat  cagaataaa  aatggcgta  tcatttgtg  gacaccaac  agattttcc  120
tatactgtc  caaaattta  agatcaatt  ccccagagg  tgtgcaatg  atcataaaa  180
ggccttttt  agggtggga  aggaaggca  attacattg  tccatgata  gcatgcaag  240
ctgctatcc  acatatata  cttatatac  tttggtgac  tagaaaaac  aatcatttg  300
gacaagcct  aaaagcctg  catatttaa  atacgtcag  aggttctgt  tggccgagg  360
tctccagtt  gaccatgtg  ccctgtgaa  gtgtcagaa  gccaatttt  ttaagtttg  420
agcagaaca  catatccac  ctaaagaat  caatgtgga  tgaatcgaa  gtggagacc  480
taccttaac  aagaaagca  aagtatgtc  gtgtaaaat  tggactaaa  tgcttt  536



<210> 5051
<211> 2047
<212> DNA
<213> Homo sapiens
<308> AK024969
<400> 5051

gcgggttcc  gttgtctgg  gcccagcgg  gggtgtgag  gtccgtaag  agcagcttc  60
aggatcctg  gatccggag  agccggggt  ggagcggct  ctcaagagt  actgatcta  120
gaaatggca  agaatggaa  aaattgtga  cagagacgt  tagcaatga  caaggaaca  180
cataatgga  atttcacag  cccctcttc  gtgaatgaa  agaagagga  ggagcggga  240
gaaaggcag  atattgtcc  gtggagaca  ccgctcatt  ccttgcagt  tttttctct  300
gaaatcctt  taatcttga  ggaatggac  tcaaaatta  ggcatcgtc  aagcattgt  360
gtgtctttt  tactgctgc  tgctgtgct  atagctacg  attatgttg  aggagtgca  420
caacagtat  tgcaacgta  agagaaaca  tttcttttg  atgcctact  gataggctt  480
ggaattttg  cttctgttg  gcttggaac  gggctgcac  cctttctgc  ttatctggg  540
ccacatata  cctcagtta  attagctgc  tatgaatgc  attcagtta  ttttcccga  600
ccaccctat  ctgatcaga  tatttgtcc  gatgaagag  gcactgaag  aaccatttc  660
ttgtggagt  tcatctcaa  agttaggat  gaagcctgc  tgtggggta  cggtacagc  720
atcggagag  tgcctccat  tttcatggc  agagcagct  gcctctcag  tgctgaacc  780
gatgatgaa  agtatcagg  atttgaaga  atgctggaa  atgcagagt  tgcacaaga  840
tttgcctcc  gggccaaac  ggcagttca  aaactagta  agaaagttg  attttttgg  900
attttggcc  gtgcttcaa  tccaaatcc  ttatttgat  tggctggaa  aacgtgtgg  960
cactttctg  taccttttt  gaccttctt  ggtgcaacc  taattggaa  agcaataat  1020
aaaatgcat  tccagaaaa  ttttgttat  ataacattc  gcaagcgca  agtggagca  1080
atggtggct  tcattggtg  tgtccccgg  ataggtcca  ctctgcaga  gccatttca  1140
gagtacctg  aggctcaac  gcagaagct  caccacaaa  gcgaaatgg  cacaccaca  1200
ggagaaaac  ggttgtcct  gatgtttga  aagttggtc  ttgtcatgg  gtgttactt  1260
atcctatct  tcattaact  catggcaca  agttatgcc  aacgaatcc  gcagcggtt  1320
aactcagag  agaaaacta  ataagtaga  aaagtttta  actgcagaa  ttggagtgg  1380
tgggttctg  cttaaattg  gaggactcc  agccgggaa  gaaaattcc  ttttccaac  1440
tgtatcaat  tttacaact  ttttcctga  agcagttta  tccatactt  gcactgaca  1500
actttttcc  tctgtgcta  ggtaaggta  ccaccctcg  tgcaatcca  cttgtgttt  1560
cttagggtg  aatgtgatg  tcagcagca  acttgcaac  gactggcct  ctgtttgtt  1620
ctttcaaaa  gcccacatg  tacaattag  gaattccca  cgcacaaaa  aagttccta  1680
gtatgttaa  tatgtcaag  tttttaggc  tgtcacaaa  gattgcttt  ttttcctaa  1740
tcatcaaaa  gtatataaa  tatctagat  ggataacag  cttgcatgt  tatcatgtt  1800
caatttaat  ttccatcct  cccaaccct  cctctccca  cctcaaaaa  gggccattt  1860
atgatgcat  gcacaccct  tggggaaat  gatctttaa  ttttgagac  gtataagga  1920
aatctggtt  gtgtcttac  agtgagctg  caccatttt  tattctgtg  atttagaat  1980
aagtcttga  aaaaacttt  taaagacat  tttaatcat  ccaaaaaaa  aaaaaaaaa  2040
aaaaaaa  2047



<210> 5052
<211> 164
<212> PRT
<213> Homo sapiens
<308> AAF28970
<400> 5052

Arg Ala Lys Leu Ala Val Gln Lys Leu Val Gln Lys Val Gly Phe Phe 
  1               5                  10                  15
Gly Ile Leu Ala Cys Ala Ser Ile Pro Asn Pro Leu Phe Asp Leu Ala 
             20                  25                  30
Gly Ile Thr Cys Gly His Phe Leu Val Pro Phe Trp Thr Phe Phe Gly 
         35                  40                  45
Ala Thr Leu Ile Gly Lys Ala Ile Ile Lys Met His Ile Gln Lys Ile 
     50                  55                  60
Phe Val Ile Ile Thr Phe Ser Lys His Ile Val Glu Gln Met Val Ala 
 65                  70                  75                  80
Phe Ile Gly Ala Val Pro Gly Ile Gly Pro Ser Leu Gln Lys Pro Phe 
                 85                  90                  95
Gln Glu Tyr Leu Glu Ala Gln Arg Gln Lys Leu His His Lys Ser Glu 
             100                105                110
Met Gly Thr Pro Gln Gly Glu Asn Trp Leu Ser Trp Met Phe Glu Lys 
         115                120                125
Leu Val Val Val Met Val Cys Tyr Phe Ile Leu Ser Ile Ile Asn Ser 
     130                135                140
Met Ala Gln Ser Tyr Ala Lys Arg Ile Gln Gln Arg Leu Asn Ser Glu 
 145                150                155                160
Glu Lys Thr Lys 
                 165



<210> 5053
<211> 409
<212> DNA
<213> Rattus norvegicus
<308> AA859966
<400> 5053

ttttttttt  tttttttca  ctttattcc  gtaatttaa  agaagatta  aataataga  60
aatatgaaa  agatgaaga  aaccgagct  gtacaggtc  aggccagcc  agtataaag  120
taaggaggc  tggagaatg  tgaggcagg  gagtggaga  ctctgttgc  atggcggaa  180
gcagcttgg  gtatggttg  tggtactgt  tccttctac  cgtgtgttc  atgtgttaa  240
aaatgggaa  cggaatcct  cctcattct  aaccagatg  taagagaaa  atggcagaa  300
gaggttgtg  tatccaggc  gctcgggcc  gctttgaac  ctctaattt  ttcaaagta  360
acgcttcgg  ccccgcggg  cactcagct  agagcatcg  gggggcgcc  409



<210> 5054
<211> 549
<212> DNA
<213> Rattus norvegicus
<308> AA859982
<400> 5054

ggttttatt  tgtttttag  ttttggcaa  atgccaagc  ctgggtcat  cctgccttc  60
gtgtgtaag  tagaacctt  cattgagta  taaagagtt  atgtgcatg  ctaaacagt  120
ccatctagc  actataaag  cattggaac  agcagtatg  ttctgacct  atcctatgt  180
gtagatatg  ccacacttt  ggagaattc  caaagttgt  acattgaga  attccttta  240
gccattatg  aaaattaat  ttctgtcca  aatgactgt  tagagacag  aaaaataga  300
agttgggcc  aaaagcaat  tgaagtaag  atttaaata  aaccccatt  taaaaaaat  360
aatttctat  taagtaatt  gttgtaata  agcccagta  ttaataaaa  gtacaatgt  420
taagtctca  ctaacttct  ggtttgatt  ctagagttc  gcctctcac  tggctccct  480
gattggttt  atttgtttg  ttgcttgtt  tttaatttt  ttaaaaggt  cttatatta  540
cctaccttc  549



<210> 5055
<211> 570
<212> DNA
<213> Rattus norvegicus
<308> AA859996
<400> 5055

ttttttttt  tttttttat  tttatattt  atataatta  taaaacagt  cttgtataa  60
aattcacac  aagttgcta  agagcatac  agttccaaa  aatgtcctg  gtttgtggt  120
cattcagtt  tctaagggt  cactcagat  agtgtaaca  gcagacatg  cgtggtatc  180
cgttctctt  ggtaaaact  ttcttgtta  atcactcct  acagtagtc  ctctgatat  240
cactttgtg  aaggtctgc  cttcctggg  tgtcagaca  actatttta  tgaacatca  300
aatgtcggg  ctaatctct  gtcctctgg  tacaaggca  aaataatct  aaacacgga  360
aatttagat  gggacagga  aagcaattg  caacaagat  ttatgagac  cattaaatt  420
tgaaaaaat  agtatttta  attatattg  ttcatggaa  aaaaaatgc  cactggagc  480
tcctgtacg  atggggaac  gaggaccat  cagtccagc  ggggcacga  acagctccc  540
gagtgtcca  ctcgtttca  tgaaagggac  570



<210> 5056
<211> 5538
<212> DNA
<213> Homo sapiens
<308> AB046773
<400> 5056

ggcaaacgc  agcaacagc  cctcgtcac  gcggctcct  aatgagcca  agaagcggg  60
ctgtggcag  accggggca  gcactgaca  cgaccccaa  atctacttc  tgatccaga  120
gatgttcta  atgctgaac  ccctcacgt  caacatgtc  cagctgcac  gcaaggtgg  180
cctgctctc  cttgaggtg  gccgcatca  gaagcaggt  agccccact  agatggtgg  240
caaattcca  ccgccccct  agtaccagc  cacagccgc  gagctcaag  agatcgtgg  300
ccagagcct  tcagggggg  acctggcct  ccgcttgct  gtgcagctc  tccccgagc  360
cttcagcga  gtggacttc  cccggggct  cagtgcctg  ggctttgcg  ccaagcgca  420
gctggagtc  ctgcacctg  agctcatcc  caactatgt  gaggtctac  acccctcgg  480
gaaggacac  gctgtgtgg  aggccgagt  cctgcccca  ctgaacgac  tcttcagcc  540
cttctgggc  cagcgggaa  tggaggaca  ccagcccag  ggccaggtc  ccagcttct  600
tgaggcaga  caggtggac  ccggccact  cctggacaa  aaagaccag  aggaggccc  660
gtctcttga  cggagcagc  ccatcgcct  agaccacgt  gtggacacg  aggacctca  720
tgagttcct  gacgaagcc  cctcaccag  cgactttgc  gtcttcctc  tccaccggc  780
cttccccga  ctcttcgac  accgcaagc  gggtgaaca  tacagctgc  acggggacg  840
tggaaagca  gagctggac  cgcagcggc  gcagatcat  cgcaactac  cggagatct  900
cttccctga  atgcaggag  aggaggcct  gctgcagca  tgtgcccag  gcatcaacg  960
cgagctcga  ggcctgggg  tggacgcgg  cagtgaagg  gaccccccg  gtgatgact  1020
ctacgactc  tccagtctg  ccgacgaca  ctcagtggt  aaggtggag  acagcttcg  1080
gggcgagcg  ccgggtcgc  gctccaaga  gatctggct  gtgcccatc  acttcgaca  1140
gttagagat  ccccagcct  acttcgagg  gcccggtgc  gactgcctg  tcagcaagg  1200
gcagctacg  agcatctac  agagcagcc  gtccatcgg  aacttcgcc  cgcgcctgc  1260
ggtgcacct  ttccccgag  tcttcacgc  cgagaacct  cgcaagcag  acaactgca  1320
cggctccct  ggcaagaag  agctggacc  ctcccgcat  aagctcatc  gccactacg  1380
gcagctgct  tacccacgc  ccaaaaacg  ccgcgtctg  accctggag  tcgtgggca  1440
actggatga  cgctgccgg  gccgggaca  ggagcaaag  cgctcctac  agcagcagc  1500
caaggtcca  gtgccgggc  ctgagtgca  agacttgac  agctatgca  tcaaccccg  1560
gaggttccg  gaggagttt  aggggcccc  actgccccc  gagaggagc  gcaaggact  1620
ttgcaagat  cccttggac  agctggtgg  cccctcgcc  gacttcccg  tgccttctc  1680
ctacctgct  tctgacaag  aggtgcgtg  gatcgtgca  cagagcctc  ccgtgggca  1740
ctttgccgc  cggctcctc  tccgcctgt  tcccgaact  ttcaccgcc  agaacctcc  1800
gctgcagta  aaccattcc  gggcttgca  caagaagca  ctggacccc  cgcggctgc  1860
gctcatccg  cactacgtg  aagccgtct  cccggtgga  aagatggag  aggtgtggc  1920
ctacgaatg  atccccagc  tcgatgaga  gtgccgccg  cccaacagg  aaaaatgcg  1980
catcctcaa  aaagcaaag  aagtggaga  gtgaaggcc  gtgacctgc  cagagattc  2040
gggtcacca  aggctgagc  atgggcacc  ttgggactg  gcaatactt  ggagcacgc  2100
tatggcatc  acagacagg  accttatgt  cgtggggag  ggcttacta  atttgcaca  2160
gtaaacacc  acccaaccg  aagaaagaa  ccttgagtt  ggtctcttg  acttacaac  2220
tctgtccta  gtgccccgg  ggggcagcc  gagtgtggg  agagcaagc  gtgagggca  2280
ggaccagag  ttaggggtc  tctctccct  gttgtgccc  ccccagccc  tcacagctt  2340
taatgcaaa  ccagcaact  tcttgcccc  cttcccata  tttacatct  ccattttga  2400
ccatttttt  ttaattaaa  agaaaccct  aaaaaaaat  attgggctc  ttgggggcc  2460
ttttactta  aaaaaaatc  ctttaaaag  gccatgttc  tgcacagtg  ctaatcata  2520
cttcaggtg  catggatac  gattttact  accttgttt  ttacatctg  ttttggaag  2580
gtcaagatg  cccttggat  gcagtagag  ggatggaat  gtgcgaagt  ctttacgac  2640
acatgcaag  tttcccttc  gctctggtg  cagggaagg  ttccgttca  cttggcctg  2700
ccttcaggc  cgttggtag  atgttgtgt  actctttag  cgagaacac  ggatgatga  2760
gatatgaat  tagacagcc  tggaaacac  ttcgcagtg  ctccatctg  gccgtgtcc  2820
tccgctgcc  ccattcctt  tccatacat  gttgctggt  ggagggagt  gacatgttt  2880
cttggaaaa  agtgcaggg  cttttggct  cttgttaga  ttaagggtg  gcctctttg  2940
gctcaccat  aactgttta  ttttccgtg  gtgtatttg  acaaaatcc  ggttccggg  3000
gctttgtgg  gacttcccc  gacctcagt  ttagctact  caggcagta  tacatcctc  3060
ttcctcagg  cgggcccag  tctgggccc  tcttgggga  accatgcat  ggaaggaca  3120
aggccattt  agatggggt  cacatgtcc  ttcccaggg  ccactcaga  ctttcctct  3180
ggactctct  gaaggtcct  ctgtcctat  cctggccac  ccctgcctt  gggggcaca  3240
gtcttcgtt  cctcccgac  gggaatgtc  ggctcctgc  ggccagctg  atgctctcc  3300
ggagcacca  ctgggaaat  ccctgacag  taaagtcct  taaaatgat  cttttacct  3360
cctaactct  ggggccaaa  gcttaagag  gaaaggaaa  agtcgaatg  aaacagtat  3420
tcataccag  gtcctggaa  atttattga  tcacacagg  tagtcatag  acccctgtg  3480
gatggctta  tattttgct  ctttaaaat  cagagataa  agaaacaat  tggattttc  3540
tcattcagc  gataagaac  tcagttcca  tggctgtat  acataattt  gcctgtacc  3600
aggagcatt  tttaaaata  aggatttta  aagcaatgt  aagttgctg  tctaactag  3660
aaatttgct  ctaagtgtc  tttacagat  atttctgtt  aaactgcaa  cagatttag  3720
aaggcacag  gactgaatg  ctctctgtc  tacacagct  ctcatgcac  cacgcactg  3780
ttactaaaa  ctgaagtga  atgaagggg  cctacacga  taacaagtt  aacttcttt  3840
tgcctggaa  ggagggact  gagcagcca  gagactcac  ttcccccct  gcttgggcc  3900
ttctctatg  cttagtctc  ccagcacat  cacacagca  gcacacaca  gcaccctac  3960
caaagacag  tgtggccct  tcccaccac  tcccccttc  caccgctgg  tgttggggg  4020
tggaggcgg  aggtcccat  gaatttgtt  tggtttcta  gatgtaaac  aggactcca  4080
gccatgaat  gccctgctt  ctagagggt  gaatgttga  cctgcaact  tagaagcac  4140
atcatttat  aataatttt  ttgaaactc  catctaccc  tgttagaga  atcaacagg  4200
tctaggaat  aaatatgtc  ctttgtaac  cagagcatg  tcaattttt  gaaaccgta  4260
ttcagtgat  ttcttaata  cttacatgt  tagggcatc  tcccccaga  tcttacagt  4320
cctttctgt  aagagaagt  gacacacgt  ggaactctc  ccatctctg  actgtcgtc  4380
ggaaacgcc  gcaggtcct  gccctgtct  tatggtgtc  tcacttctc  atccataca  4440
gtggctcca  tgggcattt  tttatttta  attttttac  tgaagcaat  gaagtacaa  4500
atacttatt  tttcaaaat  taatgtgtt  catgaaacc  gttggcagt  gctttcctt  4560
ccccacatc  aaattcttt  gtttttagt  gtttgtttt  tggaatttt  ttttttttt  4620
ttttggcct  gtatcccaa  gactaaaag  ttagcacag  cacgttttg  tgttgaatg  4680
actagtaag  cacagtagg  ggtagtctt  attgatttc  ctgtaagtt  ttaaagaat  4740
tatgaagat  gtcacgaat  tactgagtg  tcgcatccc  cttcagttc  ccttggctg  4800
gtctacagg  caacaaatg  ttgacaggg  ataaagtcg  gtctggtgt  atttgcgct  4860
gcgtgcccc  cccctttcg  tgttggctc  aaaccttcc  ttcctttta  gtttgtggg  4920
agtggggaa  cacatcagc  gcaatcatc  accaaccaa  caatgggat  tacttagtg  4980
tgaatagat  ggctattta  ttggtaaaa  ttgctggtc  gaccacacc  cagcatgac  5040
actgggttc  tttagagat  gcctccgtt  ccaacgttc  ccacaaatg  ttgcttctt  5100
cccagtcaa  aggggatct  gagactccc  agtggaggt  gtgagcttg  accccgcct  5160
gctgtgtag  tcgactgta  agatacatg  agtgggggt  agggccaag  ggctattac  5220
gctgttggg  aatacttgc  tctcgtaga  ccagcctta  tgtttttct  acatcctag  5280
aatagcaga  cctgcacaa  gtggatatc  gacttaata  tgtgaggag  caaaataat  5340
agaatagtt  taccaaaga  aatgaaatc  cgcatcatg  ctgcatttt  ccatagatt  5400
gagtgcatc  ttaggaaac  gaatgtaac  aaaacccag  acatttttg  aaattgtat  5460
ctctctagc  actttgtgt  aatttttat  caaacactg  tttatgagt  atataaaat  5520
ttataaaaa  agaaaaac  5538



<210> 5057
<211> 417
<212> DNA
<213> Rattus norvegicus
<308> AA860010
<400> 5057

ttttttttt  tttttttga  agtagccat  tcagtttta  tttgacatt  cactcacat  60
caagggggt  ggaggtgta  ataatccag  aagcatctc  ccatcagga  attatgtct  120
ggggcttgg  atacagagg  gaggtgcag  ctgcattca  tggagaaag  ggaagccca  180
ggggagctg  aactgagta  ggtcttatg  gaactggta  caaggagcc  gggtaaggc  240
tctggcaag  aggtcccct  agtctgtca  gatgctgtg  atggggttc  gaaggacag  300
accctaaaa  agagaacaa  cttgcccta  tttgcttcc  accttggtc  ctatatgca  360
tcatgaccc  gaatcccat  gctgttaac  tctgaggtc  aattcctta  ggactgg  417



<210> 5058
<211> 512
<212> PRT
<213> Rattus norvegicus
<308> AAH11490
<400> 5058

Met Ala Pro Ser His Pro Ala Phe Gln Phe Trp Ile His Leu Tyr Leu 
  1               5                  10                  15
Trp Cys Leu Leu Leu Met Pro Ala Val Leu Ala Gln Gln Gly Ser His 
             20                  25                  30
Thr His Ala Glu Asp Arg Leu Phe Lys His Leu Phe Gly Gly Tyr Asn 
         35                  40                  45
Arg Trp Ala Arg Pro Val Pro Asn Thr Ser Asp Val Val Ile Val Arg 
     50                  55                  60
Phe Gly Leu Ser Ile Ala Gln Leu Ile Asp Val Asp Glu Lys Asn Gln 
 65                  70                  75                  80
Met Met Thr Thr Asn Val Trp Leu Lys Gln Glu Trp Asn Asp Tyr Lys 
                 85                  90                  95
Leu Arg Trp Asp Pro Ala Glu Phe Gly Asn Ile Thr Ser Leu Arg Val 
             100                105                110
Pro Ser Glu Met Ile Trp Ile Pro Asp Ile Val Leu Tyr Asn Asn Ala 
         115                120                125
Asp Gly Glu Phe Ala Val Thr His Met Thr Lys Ala His Leu Phe Phe 
     130                135                140
Thr Gly Thr Val His Trp Val Pro Pro Ala Ile Tyr Lys Ser Ser Cys 
 145                150                155                160
Ser Ile Asp Val Thr Phe Phe Pro Phe Asp Gln Gln Asn Cys Lys Met 
                 165                170                175
Lys Phe Gly Ser Trp Thr Tyr Asp Lys Ala Lys Ile Asp Leu Glu Gln 
             180                185                190
Met Glu Arg Thr Val Asp Leu Lys Asp Tyr Trp Glu Ser Gly Glu Trp 
         195                200                205
Ala Ile Ile Asn Ala Thr Gly Thr Tyr Asn Ser Lys Lys Tyr Asp Cys 
     210                215                220
Cys Ala Glu Ile Tyr Pro Asp Val Thr Tyr Tyr Phe Val Ile Arg Arg 
 225                230                235                240
Leu Pro Leu Phe Tyr Thr Ile Asn Leu Ile Ile Pro Cys Leu Leu Ile 
                 245                250                255
Ser Cys Leu Thr Val Leu Val Phe Tyr Leu Pro Ser Glu Cys Gly Glu 
             260                265                270
Lys Ile Thr Leu Cys Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu 
         275                280                285
Leu Leu Ile Thr Glu Ile Ile Pro Ser Thr Ser Leu Val Ile Pro Leu 
     290                295                300
Ile Gly Glu Tyr Leu Leu Phe Thr Met Ile Phe Val Thr Leu Ser Ile 
 305                310                315                320
Val Ile Thr Val Phe Val Leu Asn Val His His Arg Ser Pro Ser Thr 
                 325                330                335
His Asn Met Pro Asn Trp Val Arg Val Ala Leu Leu Gly Arg Val Pro 
             340                345                350
Arg Trp Leu Met Met Asn Arg Pro Leu Pro Pro Met Glu Leu His Gly 
         355                360                365
Ser Pro Gly Leu Lys Leu Ser Pro Thr Tyr His Trp Leu Glu Thr Asn 
     370                375                380
Met Asp Ala Glu Glu Arg Glu Glu Thr Glu Glu Glu Glu Glu Glu Glu 
 385                390                395                400
Glu Asp Glu Asn Ile Cys Met Cys Ala Gly Leu Pro Asp Ser Ser Met 
                 405                410                415
Gly Val Leu Tyr Gly His Gly Ser Leu His Leu Arg Ala Met Gly Pro 
             420                425                430
Glu Ala Lys Thr Pro Ser Gln Ala Ser Glu Ile Leu Leu Ser Pro Gln 
         435                440                445
Ile Gln Lys Ala Leu Glu Gly Val His Tyr Ile Ala Asp His Leu Arg 
     450                455                460
Ser Glu Asp Ala Asp Ser Ser Val Lys Glu Asp Trp Lys Tyr Val Ala 
 465                470                475                480
Met Val Val Asp Arg Ile Phe Leu Trp Leu Phe Ile Ile Val Cys Phe 
                 485                490                495
Leu Gly Thr Ile Gly Leu Phe Leu Pro Pro Phe Leu Ala Gly Met Ile 
             500                505                510



<210> 5059
<211> 2664
<212> DNA
<213> Homo sapiens
<308> NM_000742
<400> 5059

gagagaaca  cgtgagcct  tgtgcttgt  tgctgagcc  tcatcccct  ctggggcca  60
gcttgggtt  cacctgcag  atcgcttgt  ctgggctgc  tgggctgtc  tcagtggca  120
ctgcatgaa  ccgttctgg  tgccagagc  ggacagccc  aggaaaacc  acctctctg  180
agagcttgc  cagctgtcc  cgggaagcc  aatgcctct  atgtaagtc  tctgctcga  240
ggggtgtct  ctaaaccct  actcttcag  ctctgtttg  ccatgaaat  aagtgactg  300
gctctattc  gtacctgcc  ctctatttc  ggggtgact  ttgtcagct  cccagaatc  360
ccaagccag  ctggttctc  gcatccttt  aatgacctg  tttcttctg  aaccacagg  420
tcggtggtg  gaggaagcc  cgcagaatc  agcagaatc  tcacagaat  cagcagcag  480
tctgctggg  acatggtcc  tggtgcaac  cacagcaaa  ccctgacct  acctcctga  540
gctcaggag  agccatggg  ccctcctgt  ctgtgttcc  gtccttcac  aagctcagc  600
tgtggtggc  ccttctgac  ccagcaggt  gagaggaag  taagcgccc  cctcccagg  660
ctcctggag  cccactctc  tctcccagt  ccacggcat  gccgcaggg  ggctcgcat  720
ccgagactg  ggaccggct  ttcaaacac  tcttccggg  ctacaaccg  tgggcgcgc  780
cggtgccca  cacttcaga  gtggtgatt  tgcgctttg  actgtccat  gctcagctc  840
tcgatgtgg  tgagaagaa  caaatgatg  ccaccaacg  ctggctaaa  caggagtgg  900
gcgactaca  actgcgctg  aaccccgct  attttggca  catcacatc  ctcagggtc  960
cttctgaga  gatctggat  cccgacatt  ttctctaca  caatgcaga  ggggagttt  1020
cagtgaccc  catgaccaa  gcccacctc  tctccacgg  cactgtgca  tgggtgccc  1080
cggccatct  caagagctc  tgcagcatc  acgtcacct  cttcccctt  gaccagcag  1140
actgcaaga  gaagtttgg  tcctggact  atgacaagg  caagatcga  ctggagcag  1200
tggagcaga  tgtggacct  aaggactac  gggagagcg  cgagtgggc  atcgtcaat  1260
ccacgggca  ctacaacag  aagaagtac  actgctgcg  cgagatcta  cccgacgtc  1320
cctacgcct  cgtcatccg  cggctgccg  tcttctaca  catcaacct  atcatcccc  1380
gcctgctca  ctcctgcct  actgtgctg  tcttctacc  gccctccga  tgcggcgag  1440
agatcacgc  gtgcatttc  gtgctgctg  cactcaccg  cttcctgct  ctcatcact  1500
agatcatcc  gtccacctc  ctggtcatc  cgctcatcg  cgagtacct  ctgttcacc  1560
tgatcttcg  caccctgtc  atcgtcatc  ccgtcttcg  gctcaatgt  caccaccgc  1620
cccccagca  ccacaccat  ccccactgg  tgcgggggg  ccttctggg  tgtgtgccc  1680
ggtggcttc  gatgaaccg  cccccacca  ccgtggagc  ctgccaccc  ctacgcctg  1740
agctcagcc  ctcttatca  tggctggag  gcaacgtgg  tgccgagga  agggaggtg  1800
tggtggagg  ggaggacag  tgggcatgt  caggtcatg  ggccccctc  gtgggcacc  1860
tctgcagcc  cggccacct  cactctggg  cctcaggtc  caaggctga  gctctgctg  1920
aggagggtg  gctgctgct  tcaccccac  tgcagaagg  actggaagg  gtgcactac  1980
ttgccgacc  cctgcggtc  gaggatgct  actcttcgg  gaaggagga  tggaagtat  2040
ttgccatgg  catcgacag  atcttcctc  ggctgttta  catcgtctg  ttcctgggg  2100
ccatcggcc  ctttctgcc  ccgttccta  ctggaatga  ctgactgca  ctccctcga  2160
ctggctccc  gggcaaagg  gagggttct  ggatgtgga  gggctttga  caatgttta  2220
atttggaga  gagcccaaa  tgccaggga  aacagccag  tgaggtggg  ggttggaga  2280
ccaggtgag  tctctctaa  tcaggctgg  gttgaagtt  ggagtctgt  cgagtttgc  2340
gggtgctga  ctgtatggt  cagcagggg  gtaataagg  ctcttccgg  aggggagga  2400
gcgggaggc  ggcctgcac  tgatgtgga  gtacaggca  atcttccct  ccggggagg  2460
atggatggt  ggatacagg  ggctgggct  ttccatcca  ctggaagca  atttgagcc  2520
ccaggcttc  ccttgacgt  attcctctc  ttccttgct  caaaatggc  ctgcaccag  2580
cggccccca  gaggtctgg  agagctgag  gccatggcc  gcaggggct  catatgtcc  2640
tacgcgtgc  gcaggcaaa  aaga  2664



<210> 5060
<211> 529
<212> PRT
<213> Homo sapiens
<308> Q15822
<400> 5060

Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Thr Lys Leu Ser Leu 
  1               5                  10                  15
Trp Trp Leu Leu Leu Thr Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
             20                  25                  30
Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Thr Ala 
         35                  40                  45
Leu Pro Gln Gly Gly Ser His Thr Glu Thr Glu Asp Arg Leu Phe Lys 
     50                  55                  60
His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Thr 
 65                  70                  75                  80
Ser Asp Val Val Ile Val Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile 
                 85                  90                  95
Asp Val Asp Glu Lys Asn Gln Met Met Thr Thr Asn Val Trp Leu Lys 
             100                105                110
Gln Glu Trp Ser Asp Tyr Lys Leu Arg Trp Asn Pro Ala Asp Phe Gly 
         115                120                125
Asn Ile Thr Ser Leu Arg Val Pro Ser Glu Met Ile Trp Ile Pro Asp 
     130                135                140
Ile Val Leu Tyr Asn Asn Ala Asp Gly Glu Phe Ala Val Thr His Met 
 145                150                155                160
Thr Lys Ala His Leu Phe Ser Thr Gly Thr Val His Trp Val Pro Pro 
                 165                170                175
Ala Ile Tyr Lys Ser Ser Cys Ser Ile Asp Val Thr Phe Phe Pro Phe 
             180                185                190
Asp Gln Gln Asn Cys Lys Met Lys Phe Gly Ser Trp Thr Tyr Asp Lys 
         195                200                205
Ala Lys Ile Asp Leu Glu Gln Met Glu Gln Thr Val Asp Leu Lys Asp 
     210                215                220
Tyr Trp Glu Ser Gly Glu Trp Ala Ile Val Asn Ala Thr Gly Thr Tyr 
 225                230                235                240
Asn Ser Lys Lys Tyr Asp Cys Cys Ala Glu Ile Tyr Pro Asp Val Thr 
                 245                250                255
Tyr Ala Phe Val Ile Arg Arg Leu Pro Leu Phe Tyr Thr Ile Asn Leu 
             260                265                270
Ile Ile Pro Cys Leu Leu Ile Ser Cys Leu Thr Val Leu Val Phe Tyr 
         275                280                285
Leu Pro Ser Asp Cys Gly Glu Lys Ile Thr Leu Cys Ile Ser Val Leu 
     290                295                300
Leu Ser Leu Thr Val Phe Leu Leu Leu Ile Thr Glu Ile Ile Pro Ser 
 305                310                315                320
Thr Ser Leu Val Ile Pro Leu Ile Gly Glu Tyr Leu Leu Phe Thr Met 
                 325                330                335
Ile Phe Val Thr Leu Ser Ile Val Ile Thr Val Phe Val Leu Asn Val 
             340                345                350
His His Arg Ser Pro Ser Thr His Thr Met Pro His Trp Val Arg Gly 
         355                360                365
Ala Leu Leu Gly Cys Val Pro Arg Trp Leu Leu Met Asn Arg Pro Pro 
     370                375                380
Pro Pro Val Glu Leu Cys His Pro Leu Arg Leu Lys Leu Ser Pro Ser 
 385                390                395                400
Tyr His Trp Leu Glu Ser Asn Val Asp Ala Glu Glu Arg Glu Val Val 
                 405                410                415
Val Glu Glu Glu Asp Arg Trp Ala Cys Ala Gly His Val Ala Pro Ser 
             420                425                430
Val Gly Thr Leu Cys Ser His Gly His Leu His Ser Gly Ala Ser Gly 
         435                440                445
Pro Lys Ala Glu Ala Leu Leu Gln Glu Gly Glu Leu Leu Leu Ser Pro 
     450                455                460
His Met Gln Lys Ala Leu Glu Gly Val His Tyr Ile Ala Asp His Leu 
 465                470                475                480
Arg Ser Glu Asp Ala Asp Ser Ser Val Lys Glu Asp Trp Lys Tyr Val 
                 485                490                495
Ala Met Val Ile Asp Arg Ile Phe Leu Trp Leu Phe Ile Ile Val Cys 
             500                505                510
Phe Leu Gly Thr Ile Gly Leu Phe Leu Pro Pro Phe Leu Ala Gly Met 
         515                520                525
Ile 
     530



<210> 5061
<211> 607
<212> DNA
<213> Rattus norvegicus
<308> AA860015
<400> 5061

ttttttttt  tttttttgc  tttcatttt  tattaccaa  caaaaataa  ttccatata  60
tgtttagca  atattataa  tgttttgtg  caaaagaca  aagagtcat  acaacaaaa  120
tccccgaga  tcaaactca  aacaatgcc  aaataaatc  caaaaatat  cagattaaa  180
tcttaatgc  aaataaata  gagtcatct  ctatggcgg  tgtgacttg  ctacccact  240
ggacgccgt  tgtggagtc  tcccctgct  ggaagacac  cagaccagg  cagttccag  300
gtatggctc  gcccaggaa  cagaggttg  aagaagtga  aaattgcac  atgaggagg  360
agtcatcag  acagtaata  ttggaaata  ttatgaccc  ctgcaagaa  tgattctaa  420
tgaggaagg  aggggcggg  cccggctgt  ggtgactgt  tatgcacag  ggtanctgt  480
gaagtgtgt  cacctgcta  gtttgcctc  cacccacca  agggttttg  tctacctgg  540
acttaggtc  cacagtaac  cagctatgc  cctcatcta  agactcagg  gcatgccgc  600
cctacag  607



<210> 5062
<211> 374
<212> DNA
<213> Homo sapiens
<308> F34867
<400> 5062

tagcattcg  cngcnctcc  cctnttccc  ggcccattg  tcatccctt  tcacagagg  60
tcatcatta  ttccaaata  tgtttgtct  atgacttcc  cttcccagt  caatttttc  120
cttcctatt  caacctctg  gtcctggga  gagccatac  ctggaactg  cccacccac  180
gtgtcttcc  cgtaaggga  acctttgca  agggcatcc  aatgggtag  caggtgaca  240
ccgccgtat  tattttgca  aatatttta  tttgtatat  tttgtgatt  attttggcg  300
tatgagttt  actctcggg  agntttgtt  ttatgactc  tgtgtcttt  gtcacaaaa  360
aatgatatt  gcta  374



<210> 5063
<211> 543
<212> DNA
<213> Rattus norvegicus
<308> AA860017
<400> 5063

ttttttttt  tttttggtt  taaaagcac  atcactaaa  tttatttgt  aaccattgt  60
actattaac  ttttttgtc  tattgagga  gctgttgag  agtgttttt  gcctgtttt  120
ttaatgctc  gtgtttcta  ttgcaatat  tgaatggtg  cagctagca  ggtcaggta  180
cttatcgtg  gctgtgaac  aagtggttc  aattttttg  ggacttaaa  agaaaaaaa  240
aaaaaagag  tgttttaag  ttgttgtgg  caatgttga  tcttataag  tttccttag  300
cactcatga  aggcattcc  acttggaac  gagaagtga  gctccgtga  tgtagattt  360
tatgggttt  cttttttct  ttttttttt  tttgtttgt  ttttggtgt  tttacattt  420
acaaatttc  ttgacttta  aattggtgc  atttgaaga  aacaaaatg  acctttagt  480
atacatagg  atcaggctt  accccaaaa  accaaacaa  attgaccca  aaaatagat  540
aat  543



<210> 5064
<211> 1612
<212> PRT
<213> Rattus norvegicus
<308> CAA76850
<400> 5064

Met Ile Ala Glu Pro Ala His Phe Tyr Leu Phe Gly Leu Ile Cys Leu 
  1               5                  10                  15
Cys Ser Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val 
             20                  25                  30
Glu His Pro Ser Asp Leu Ile Val Ser Lys Gly Glu Pro Ala Thr Leu 
         35                  40                  45
Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys 
     50                  55                  60
Gly Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg 
 65                  70                  75                  80
Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val His Gly 
                 85                  90                  95
Arg Lys Ser Arg Pro Asp Glu Gly Val Tyr Ile Cys Val Ala Arg Asn 
             100                105                110
Tyr Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile 
         115                120                125
Leu Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val 
     130                135                140
Gly Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu 
 145                150                155                160
Pro Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp 
                 165                170                175
Glu Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg 
             180                185                190
Lys Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly 
         195                200                205
Glu Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu Glu Arg Pro Ser 
     210                215                220
Phe Val Lys Arg Pro Ser Asn Leu Ala Val Thr Val Asp Asp Ser Ala 
 225                230                235                240
Glu Phe Lys Cys Glu Ala Arg Gly Asp Pro Val Pro Thr Val Arg Trp 
                 245                250                255
Arg Lys Asp Asp Gly Glu Leu Pro Lys Ser Arg Tyr Glu Ile Arg Asp 
             260                265                270
Asp His Thr Leu Lys Ile Arg Lys Val Thr Ala Gly Asp Met Gly Ser 
         275                280                285
Tyr Thr Cys Val Ala Glu Asn Met Val Gly Lys Ala Glu Ala Ser Ala 
     290                295                300
Thr Leu Thr Val Gln Glu Pro Pro His Phe Val Val Lys Pro Arg Asp 
 305                310                315                320
Gln Val Val Ala Leu Gly Arg Thr Val Thr Phe Gln Cys Glu Ala Thr 
                 325                330                335
Gly Asn Pro Gln Pro Ala Ile Phe Trp Arg Arg Glu Gly Ser Gln Asn 
             340                345                350
Leu Leu Phe Ser Tyr Gln Pro Pro Gln Ser Ser Ser Arg Phe Ser Val 
         355                360                365
Ser Gln Thr Gly Asp Leu Thr Ile Thr Asn Val Gln Arg Ser Asp Val 
     370                375                380
Gly Tyr Tyr Ile Cys Gln Thr Leu Asn Val Ala Gly Ser Ile Ile Thr 
 385                390                395                400
Lys Ala Tyr Leu Glu Val Thr Asp Val Ile Ala Asp Arg Pro Pro Pro 
                 405                410                415
Val Ile Arg Gln Gly Pro Val Asn Gln Thr Val Ala Val Asp Gly Thr 
             420                425                430
Leu Ile Leu Ser Cys Val Ala Thr Gly Ser Pro Ala Pro Thr Ile Leu 
         435                440                445
Trp Arg Lys Asp Gly Val Leu Val Ser Thr Gln Asp Ser Arg Ile Lys 
     450                455                460
Gln Leu Glu Ser Gly Val Leu Gln Ile Arg Tyr Ala Lys Leu Gly Asp 
 465                470                475                480
Thr Gly Arg Tyr Thr Cys Thr Ala Ser Thr Pro Ser Gly Glu Ala Thr 
                 485                490                495
Trp Ser Ala Tyr Ile Glu Val Gln Glu Phe Gly Val Pro Val Gln Pro 
             500                505                510
Pro Arg Pro Thr Asp Pro Asn Leu Ile Pro Ser Ala Pro Ser Lys Pro 
         515                520                525
Glu Val Thr Asp Val Ser Lys Asn Thr Val Thr Leu Ser Trp Gln Pro 
     530                535                540
Asn Leu Asn Ser Gly Ala Thr Pro Thr Ser Tyr Ile Ile Glu Ala Phe 
 545                550                555                560
Ser His Ala Ser Gly Ser Ser Trp Gln Thr Ala Ala Glu Asn Val Lys 
                 565                570                575
Thr Glu Thr Phe Ala Ile Lys Gly Leu Lys Pro Asn Ala Ile Tyr Leu 
             580                585                590
Phe Leu Val Arg Ala Ala Asn Ala Tyr Gly Ile Ser Asp Pro Ser Gln 
         595                600                605
Ile Ser Asp Pro Val Lys Thr Gln Asp Val Pro Pro Thr Ser Gln Gly 
     610                615                620
Val Asp His Lys Gln Val Gln Arg Glu Leu Gly Asn Val Val Leu His 
 625                630                635                640
Leu His Asn Pro Thr Ile Leu Ser Ser Ser Ser Val Glu Val His Trp 
                 645                650                655
Thr Val Asp Gln Gln Ser Gln Tyr Ile Gln Gly Tyr Lys Ile Leu Tyr 
             660                665                670
Arg Pro Ser Gly Ala Ser His Gly Glu Ser Glu Trp Leu Val Phe Glu 
         675                680                685
Val Arg Thr Pro Thr Lys Asn Ser Val Val Ile Pro Asp Leu Arg Lys 
     690                695                700
Gly Val Asn Tyr Glu Ile Lys Ala Arg Pro Phe Phe Asn Glu Phe Gln 
 705                710                715                720
Gly Ala Asp Ser Glu Ile Lys Phe Ala Lys Thr Leu Glu Glu Ala Pro 
                 725                730                735
Ser Ala Pro Pro Arg Ser Val Thr Val Ser Lys Asn Asp Gly Asn Gly 
             740                745                750
Thr Ala Ile Leu Val Thr Trp Gln Pro Pro Pro Glu Asp Thr Gln Asn 
         755                760                765
Gly Met Val Gln Glu Tyr Lys Val Trp Cys Leu Gly Asn Glu Thr Lys 
     770                775                780
Tyr His Ile Asn Lys Thr Val Asp Gly Ser Thr Phe Ser Val Val Ile 
 785                790                795                800
Pro Ser Leu Val Pro Gly Ile Arg Tyr Ser Val Glu Val Ala Ala Ser 
                 805                810                815
Thr Gly Ala Gly Pro Gly Val Lys Ser Glu Pro Gln Phe Ile Gln Leu 
             820                825                830
Asp Ser His Gly Asn Pro Val Ser Pro Glu Asp Gln Val Ser Leu Ala 
         835                840                845
Gln Gln Ile Ser Asp Val Val Arg Gln Pro Ala Phe Ile Ala Gly Ile 
     850                855                860
Gly Ala Ala Cys Trp Ile Ile Leu Met Val Phe Ser Ile Trp Leu Tyr 
 865                870                875                880
Arg His Arg Lys Lys Arg Asn Gly Leu Thr Ser Thr Tyr Ala Gly Ile 
                 885                890                895
Arg Lys Val Pro Ser Phe Thr Phe Thr Pro Thr Val Thr Tyr Gln Arg 
             900                905                910
Gly Gly Glu Ala Val Ser Ser Gly Gly Arg Pro Gly Leu Leu Asn Ile 
         915                920                925
Ser Glu Pro Ala Thr Gln Pro Trp Leu Ala Asp Thr Trp Pro Asn Thr 
     930                935                940
Gly Asn Asn His Asn Asp Cys Ser Ile Asn Cys Cys Thr Ala Gly Asn 
 945                950                955                960
Gly Asn Ser Asp Ser Asn Leu Thr Thr Tyr Ser Arg Pro Ala Asp Cys 
                 965                970                975
Ile Ala Asn Tyr Asn Asn Gln Leu Asp Asn Lys Gln Thr Asn Leu Met 
             980                985                990
Leu Pro Glu Ser Thr Val Tyr Gly Asp Val Asp Leu Ser Asn Lys Ile 
         995                1000                1005
Asn Glu Met Lys Thr Phe Asn Ser Pro Asn Leu Lys Asp Gly Arg Phe 
     1010                1015                1020
Val Asn Pro Ser Gly Gln Pro Thr Pro Tyr Ala Thr Thr Gln Leu Ile 
 1025                1030                1035                1040
Gln Ala Asn Leu Ser Asn Asn Met Asn Asn Gly Ala Gly Asp Ser Ser 
                 1045                1050                1055
Glu Lys His Trp Lys Pro Pro Gly Gln Gln Lys Pro Glu Val Ala Pro 
             1060                1065                1070
Ile Gln Tyr Asn Ile Met Glu Gln Asn Lys Leu Asn Lys Asp Tyr Arg 
         1075                1080                1085
Ala Asn Asp Thr Ile Pro Pro Thr Ile Pro Tyr Asn Gln Ser Tyr Asp 
     1090                1095                1100
Gln Asn Thr Gly Gly Ser Tyr Asn Ser Ser Asp Arg Gly Ser Ser Thr 
 1105                1110                1115                1120
Ser Gly Ser Gln Gly His Lys Lys Gly Ala Arg Thr Pro Lys Ala Pro 
                 1125                1130                1135
Lys Gln Gly Gly Met Asn Trp Ala Asp Leu Leu Pro Pro Pro Pro Ala 
             1140                1145                1150
His Pro Pro Pro His Ser Asn Ser Glu Glu Tyr Asn Met Ser Val Asp 
         1155                1160                1165
Glu Ser Tyr Asp Gln Glu Met Pro Cys Pro Val Pro Pro Ala Pro Met 
     1170                1175                1180
Tyr Leu Gln Gln Asp Glu Leu Gln Glu Glu Glu Asp Glu Arg Gly Pro 
 1185                1190                1195                1200
Thr Pro Pro Val Arg Gly Ala Ala Ser Ser Pro Ala Ala Val Ser Tyr 
                 1205                1210                1215
Ser His Gln Ser Thr Ala Thr Leu Thr Pro Ser Pro Gln Glu Glu Leu 
             1220                1225                1230
Gln Pro Met Leu Gln Asp Cys Pro Glu Asp Leu Gly His Met Pro His 
         1235                1240                1245
Pro Pro Asp Arg Arg Arg Gln Pro Val Ser Pro Pro Pro Pro Pro Arg 
     1250                1255                1260
Pro Ile Ser Pro Pro His Thr Tyr Gly Tyr Ile Ser Gly Pro Leu Val 
 1265                1270                1275                1280
Ser Asp Met Asp Thr Asp Ala Pro Glu Glu Glu Glu Asp Glu Ala Asp 
                 1285                1290                1295
Met Glu Val Ala Lys Met Gln Thr Arg Arg Leu Leu Leu Arg Gly Leu 
             1300                1305                1310
Glu Gln Thr Pro Ala Ser Ser Val Gly Asp Leu Glu Ser Ser Val Thr 
         1315                1320                1325
Gly Ser Met Ile Asn Gly Trp Gly Ser Ala Ser Glu Glu Asp Asn Ile 
     1330                1335                1340
Ser Ser Gly Arg Ser Ser Val Ser Ser Ser Asp Gly Ser Phe Phe Thr 
 1345                1350                1355                1360
Asp Ala Asp Phe Ala Gln Ala Val Ala Ala Ala Ala Glu Tyr Ala Gly 
                 1365                1370                1375
Leu Lys Val Ala Arg Arg Gln Met Gln Asp Ala Ala Gly Arg Arg His 
             1380                1385                1390
Phe His Ala Ser Gln Cys Pro Arg Pro Thr Ser Pro Val Ser Thr Asp 
         1395                1400                1405
Ser Asn Met Ser Ala Val Val Ile Gln Lys Ala Arg Pro Ala Lys Lys 
     1410                1415                1420
Gln Lys His Gln Pro Gly His Leu Arg Arg Glu Ala Tyr Ala Asp Asp 
 1425                1430                1435                1440
Leu Pro Pro Pro Pro Val Pro Pro Pro Ala Ile Lys Ser Pro Thr Val 
                 1445                1450                1455
Gln Ser Lys Ala Gln Leu Glu Val Arg Pro Val Met Val Pro Lys Leu 
             1460                1465                1470
Ala Ser Ile Glu Ala Arg Thr Asp Arg Ser Ser Asp Arg Lys Gly Gly 
         1475                1480                1485
Ser Tyr Lys Gly Arg Glu Ala Leu Asp Gly Arg Gln Val Thr Asp Leu 
     1490                1495                1500
Arg Thr Asn Pro Ser Asp Pro Arg Glu Ala Gln Glu Gln Pro Asn Asp 
 1505                1510                1515                1520
Gly Lys Gly Arg Gly Thr Arg Gln Pro Lys Arg Asp Leu Pro Pro Ala 
                 1525                1530                1535
Lys Thr His Leu Gly Gln Glu Asp Ile Leu Pro Tyr Cys Arg Pro Thr 
             1540                1545                1550
Phe Pro Thr Ser Asn Asn Pro Arg Asp Pro Ser Ser Ser Ser Ser Met 
         1555                1560                1565
Ser Ser Arg Gly Ser Gly Ser Arg Gln Arg Glu Gln Ala Asn Val Gly 
     1570                1575                1580
Arg Arg Asn Met Ala Glu Met Gln Val Leu Gly Gly Phe Glu Arg Gly 
 1585                1590                1595                1600
Asp Glu Asn Asn Glu Glu Leu Glu Glu Thr Glu Ser 
                 1605                1610



<210> 5065
<211> 3215
<212> DNA
<213> Homo sapiens
<308> BC001969
<400> 5065

gtagtacat  tgggagtca  gggcacaag  aaggggcaa  aacacccaa  gtaccaaaa  60
agggtggca  gaactgggc  gacctgctt  ctcctcccc  agcacatcc  cctccacac  120
gcaatagcg  agagtacaa  atttctgta  atgaaagct  tgaccaaga  atgccatgt  180
ccgtgccac  agcaaggat  tatttgcaa  aagatgaat  agaagagga  gaagatgaa  240
gaggcccca  tccccctgt  cggggagca  cttcttctc  agctgccgt  tcctatagc  300
atcagtcca  tgccactct  actccctcc  cacaggaag  actccagcc  atgttacag  360
attgtccag  ggagactgg  cacatgcag  accagcccg  caggagacg  cagcctgtg  420
gtcctcctc  accaccacg  ccgatctcc  ctccacata  ctatggcta  atttcagga  480
ccctggtct  agatatgga  acggatgcg  cagaagagg  agaagacga  gccgacatg  540
aggtagcca  gatgcaaac  agaaggctt  tgttacgtg  gcttgagca  acacctgcc  600
ccagtgttg  ggacctgga  agctctgtc  cggggtcca  gatcaacgg  tggggctca  660
cctcagagg  ggacaacat  tccagcgga  gctccagtg  tagttcttc  gacggctcc  720
ttttcactg  tgctgactt  gcccaggca  tcgcagcag  ggcagagta  gctggtctg  780
aagtagcac  acggcaaat  caggatgct  ctggccgtc  acattttca  gcgtctcag  840
gccctaggc  cacaagtcc  gtgtctaca  acagcaaca  gagtgccgc  gtaatgcag  900
aaaccagac  agccaagaa  ctgaaacac  agccaggac  tctgcgcag  gaaacctac  960
cagatgatc  tccaccacc  cctgtgccg  cacctgcta  aaagtcacc  actgcccaa  1020
ccaagacac  gctggaagt  cgacctgta  tggtgccaa  actcccttc  atggatgca  1080
gaacagaca  atcatcaga  agaaaagga  gcagttaca  ggggagaga  gtgttggat  1140
gaagacagg  tgttgacat  cgaacaaat  caggtgatc  cagagaagc  caggaacag  1200
aaaatgacg  gaaaggacg  ggaaacaag  cagcaaaac  agaccttcc  ccagcaaag  1260
ctcatctca  ccaagagga  attctacct  attgtagac  tacttttcc  acatcaaat  1320
atcccagag  tcccagttc  tcaagctca  tgtcatcaa  aggatcagg  agcagacaa  1380
gagaacaag  aaatgtagg  cgaagaaat  ttgcagaaa  gcaggtact  ggaggatat  1440
aaagaggag  agataataa  gaagaatta  aggaaactg  aagctgaag  caaccaaga  1500
gcttatgag  tctaatgtg  aaatcatca  tcaagatgc  tcctgtcag  tgacacatg  1560
cgccagata  aatgttcag  gcaatcaga  tgtacaaat  gtcgttttt  ttcctctta  1620
tgggatatc  ttttaaaaa  tttattggg  ttttattgt  gttgtttga  ccctaaccc  1680
acaaagagc  ttcctattc  cctcgctgt  ggagcaaac  attatacct  acttccagc  1740
agcaaagtg  tttgacttc  tgcttcagt  atcagccag  aagagggaa  aaaactgtt  1800
ttttgcatt  tgccgctga  atatggcat  gcactgctt  tatgccaag  taatttata  1860
caagatatt  atcaaatat  gaaagttga  attcaacct  acaagggct  tcaaagtat  1920
atctttcta  agccaactg  taatgcaaa  taaaacata  ttcatttta  catgatttc  1980
aaatcagtt  ttcatacta  cctttgctg  aagaaacta  aaatatagc  aatgcagaa  2040
cacaaacaa  tcgaatggg  tagaaacat  gtaaatatt  actctttgc  aaccctggt  2100
gtattttat  ttggcttca  ttcaatcat  gaagtatat  cttattgga  atgtacttt  2160
ggataagta  ggctaagcc  gttggatct  tggttgtct  gtcattgtc  taagtaaac  2220
tagtaaaac  ttgttctat  tttcaatca  caaaaagta  ttataaata  gtattacaa  2280
caagtggat  tttttaatg  ccaattgag  aagaacatc  ctgtcttaa  tggcctaaa  2340
ttcttctgg  agtgtcagt  caactttca  aagtgccac  taaggaagt  tgatttttg  2400
ttttgtaat  cactgtttt  aatctctct  tcttttttt  ttttttttg  ttttaaaag  2460
acaatcact  aactttatt  gtaaaccat  gtaactatt  acctttttt  tcttattga  2520
aaaaaaaat  ttgagaagc  tttttaacc  gttttgtta  tgctctatg  ttgtatttg  2580
aatatttga  taatgacag  tggtgaagt  acatgcata  tttattgtg  gccatgaac  2640
aaatggttc  tacttttcc  ggacttaaa  aaaaaaaga  gtttaagtt  gttgtggcc  2700
atgtcgaaa  ctacaagat  tccttaaaa  ctctaatag  ggcattact  gctttcaat  2760
gacaaatga  gccctctga  tagtagatt  ctatgatcc  tttttgtca  tttatgaat  2820
tcattgatt  tataattgg  gctatttga  gaaaaaaat  tacatttat  catagatag  2880
taagtatca  gtctgaccc  agtggaaaa  aaagccaaa  aaaactgaa  cacaaaaaa  2940
aaggctggt  ttcaccaaa  ccaaacttg  tcatttaga  aatttgaaa  agttccata  3000
aaaaggcgt  cagtactaa  ggaacaatc  atgtgatta  tgttttcat  atgttcatg  3060
aagaagccc  ttattttta  ccataattt  gcatactga  aatccaata  tcagaaaag  3120
aattttgtc  cattattta  taaaaatgt  ctcaaatac  aaaaaaaaa  aaaaaaaaa  3180
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  3215



<210> 5066
<211> 1651
<212> PRT
<213> Homo sapiens
<308> AAC39575
<400> 5066

Met Lys Trp Lys His Val Pro Phe Leu Val Met Ile Ser Leu Leu Ser 
  1               5                  10                  15
Leu Ser Pro Asn His Leu Phe Leu Ala Gln Leu Ile Pro Asp Pro Glu 
             20                  25                  30
Asp Val Glu Arg Gly Asn Asp His Gly Thr Pro Ile Pro Thr Ser Asp 
         35                  40                  45
Asn Asp Asp Asn Ser Leu Gly Tyr Thr Gly Ser Arg Leu Arg Gln Glu 
     50                  55                  60
Asp Phe Pro Pro Arg Ile Val Glu His Pro Ser Asp Leu Ile Val Ser 
 65                  70                  75                  80
Lys Gly Glu Pro Ala Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr 
                 85                  90                  95
Pro Thr Ile Glu Trp Tyr Lys Gly Gly Glu Arg Val Glu Thr Asp Lys 
             100                105                110
Asp Asp Pro Arg Ser His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe 
         115                120                125
Phe Leu Arg Ile Val His Gly Arg Lys Ser Arg Pro Asp Glu Gly Val 
     130                135                140
Tyr Val Cys Val Ala Arg Asn Tyr Leu Gly Glu Ala Val Ser His Asn 
 145                150                155                160
Ala Ser Leu Glu Val Ala Ile Leu Arg Asp Asp Phe Arg Gln Asn Pro 
                 165                170                175
Ser Asp Val Met Val Ala Val Gly Glu Pro Ala Val Met Glu Cys Gln 
             180                185                190
Pro Pro Arg Gly His Pro Glu Pro Thr Ile Ser Trp Lys Lys Asp Gly 
         195                200                205
Ser Pro Leu Asp Asp Lys Asp Glu Arg Ile Thr Ile Arg Gly Gly Lys 
     210                215                220
Leu Met Ile Thr Tyr Thr Arg Lys Ser Asp Ala Gly Lys Tyr Val Cys 
 225                230                235                240
Val Gly Thr Asn Met Val Gly Glu Arg Glu Ser Glu Val Ala Glu Leu 
                 245                250                255
Thr Val Leu Glu Arg Pro Ser Phe Val Lys Arg Pro Ser Asn Leu Ala 
             260                265                270
Val Thr Val Asp Asp Ser Ala Glu Phe Lys Cys Glu Ala Arg Gly Asp 
         275                280                285
Pro Val Pro Thr Val Arg Trp Arg Lys Asp Asp Gly Glu Leu Pro Lys 
     290                295                300
Ser Arg Tyr Glu Ile Arg Asp Asp His Thr Leu Lys Ile Arg Lys Val 
 305                310                315                320
Thr Ala Gly Asp Met Gly Ser Tyr Thr Cys Val Ala Glu Asn Met Val 
                 325                330                335
Gly Lys Ala Glu Ala Ser Ala Thr Leu Thr Val Gln Glu Pro Pro His 
             340                345                350
Phe Val Val Lys Pro Arg Asp Gln Val Val Ala Leu Gly Arg Thr Val 
         355                360                365
Thr Phe Gln Cys Glu Ala Thr Gly Asn Pro Gln Pro Ala Ile Phe Trp 
     370                375                380
Arg Arg Glu Gly Ser Gln Asn Leu Leu Phe Ser Tyr Gln Pro Pro Gln 
 385                390                395                400
Ser Ser Ser Arg Phe Ser Val Ser Gln Thr Gly Asp Leu Thr Ile Thr 
                 405                410                415
Asn Val Gln Arg Ser Asp Val Gly Tyr Tyr Ile Cys Gln Thr Leu Asn 
             420                425                430
Val Ala Gly Ser Ile Ile Thr Lys Ala Tyr Leu Glu Val Thr Asp Val 
         435                440                445
Ile Ala Asp Arg Pro Pro Pro Val Ile Arg Gln Gly Pro Val Asn Gln 
     450                455                460
Thr Val Ala Val Asp Gly Thr Phe Val Leu Ser Cys Val Ala Thr Gly 
 465                470                475                480
Ser Pro Val Pro Thr Ile Leu Trp Arg Lys Asp Gly Val Leu Val Ser 
                 485                490                495
Thr Gln Asp Ser Arg Ile Lys Gln Leu Glu Asn Gly Val Leu Gln Ile 
             500                505                510
Arg Tyr Ala Lys Leu Gly Asp Thr Gly Arg Tyr Thr Cys Ile Ala Ser 
         515                520                525
Thr Pro Ser Gly Glu Ala Thr Trp Ser Ala Tyr Ile Glu Val Gln Glu 
     530                535                540
Phe Gly Val Pro Val Gln Pro Pro Arg Pro Thr Asp Pro Asn Leu Ile 
 545                550                555                560
Pro Ser Ala Pro Ser Lys Pro Glu Val Thr Asp Val Ser Arg Asn Thr 
                 565                570                575
Val Thr Leu Ser Trp Gln Pro Asn Leu Asn Ser Gly Ala Thr Pro Thr 
             580                585                590
Ser Tyr Ile Ile Glu Ala Phe Ser His Ala Ser Gly Ser Ser Trp Gln 
         595                600                605
Thr Val Ala Glu Asn Val Lys Thr Glu Thr Ser Ala Ile Lys Gly Leu 
     610                615                620
Lys Pro Asn Ala Ile Tyr Leu Phe Leu Val Arg Ala Ala Asn Ala Tyr 
 625                630                635                640
Gly Ile Ser Asp Pro Ser Gln Ile Ser Asp Pro Val Lys Thr Gln Asp 
                 645                650                655
Val Leu Pro Thr Ser Gln Gly Val Asp His Lys Gln Val Gln Arg Glu 
             660                665                670
Leu Gly Asn Ala Val Leu His Leu His Asn Pro Thr Val Leu Ser Ser 
         675                680                685
Ser Ser Ile Glu Val His Trp Thr Val Asp Gln Gln Ser Gln Tyr Ile 
     690                695                700
Gln Gly Tyr Lys Ile Leu Tyr Arg Pro Ser Gly Ala Asn His Gly Glu 
 705                710                715                720
Ser Asp Trp Leu Val Phe Glu Val Arg Thr Pro Ala Lys Asn Ser Val 
                 725                730                735
Val Ile Pro Asp Leu Arg Lys Gly Val Asn Tyr Glu Ile Lys Ala Arg 
             740                745                750
Pro Phe Phe Asn Glu Phe Gln Gly Ala Asp Ser Glu Ile Lys Phe Ala 
         755                760                765
Lys Thr Leu Glu Glu Ala Pro Ser Ala Pro Pro Gln Gly Val Thr Val 
     770                775                780
Ser Lys Asn Asp Gly Asn Gly Thr Ala Ile Leu Val Ser Trp Gln Pro 
 785                790                795                800
Pro Pro Glu Asp Thr Gln Asn Gly Met Val Gln Glu Tyr Lys Val Trp 
                 805                810                815
Cys Leu Gly Asn Glu Thr Arg Tyr His Ile Asn Lys Thr Val Asp Gly 
             820                825                830
Ser Thr Phe Ser Val Val Ile Pro Phe Leu Val Pro Gly Ile Arg Tyr 
         835                840                845
Ser Val Glu Val Ala Ala Ser Thr Gly Ala Gly Ser Gly Val Lys Ser 
     850                855                860
Glu Pro Gln Phe Ile Gln Leu Asp Ala His Gly Asn Pro Val Ser Pro 
 865                870                875                880
Glu Asp Gln Val Ser Leu Ala Gln Gln Ile Ser Asp Val Val Lys Gln 
                 885                890                895
Pro Ala Phe Ile Ala Gly Ile Gly Ala Ala Cys Trp Ile Ile Leu Met 
             900                905                910
Val Phe Ser Ile Trp Leu Tyr Arg His Arg Lys Lys Arg Asn Gly Leu 
         915                920                925
Thr Ser Thr Tyr Ala Gly Ile Arg Lys Val Pro Ser Phe Thr Phe Thr 
     930                935                940
Pro Thr Val Thr Tyr Gln Arg Gly Gly Glu Ala Val Ser Ser Gly Gly 
 945                950                955                960
Arg Pro Gly Leu Leu Asn Ile Ser Glu Pro Ala Ala Gln Pro Trp Leu 
                 965                970                975
Ala Asp Thr Trp Pro Asn Thr Gly Asn Asn His Asn Asp Cys Ser Ile 
             980                985                990
Ser Cys Cys Thr Ala Gly Asn Gly Asn Ser Asp Ser Asn Leu Thr Thr 
         995                1000                1005
Tyr Ser Arg Pro Ala Asp Cys Ile Ala Asn Tyr Asn Asn Gln Leu Asp 
     1010                1015                1020
Asn Lys Gln Thr Asn Leu Met Leu Pro Glu Ser Thr Val Tyr Gly Asp 
 1025                1030                1035                1040
Val Asp Leu Ser Asn Lys Ile Asn Glu Met Lys Thr Phe Asn Ser Pro 
                 1045                1050                1055
Asn Leu Lys Asp Gly Arg Phe Val Asn Pro Ser Gly Gln Pro Thr Pro 
             1060                1065                1070
Tyr Ala Thr Thr Gln Leu Ile Gln Ser Asn Leu Ser Asn Asn Met Asn 
         1075                1080                1085
Asn Gly Ser Gly Asp Ser Gly Glu Lys His Trp Lys Pro Leu Gly Gln 
     1090                1095                1100
Gln Lys Gln Glu Val Ala Pro Val Gln Tyr Asn Ile Val Glu Gln Asn 
 1105                1110                1115                1120
Lys Leu Asn Lys Asp Tyr Arg Ala Asn Asp Thr Val Pro Pro Thr Ile 
                 1125                1130                1135
Pro Tyr Asn Gln Ser Tyr Asp Gln Asn Thr Gly Gly Ser Tyr Asn Ser 
             1140                1145                1150
Ser Asp Arg Gly Ser Ser Thr Ser Gly Ser Gln Gly His Lys Lys Gly 
         1155                1160                1165
Ala Arg Thr Pro Lys Val Pro Lys Gln Gly Gly Met Asn Trp Ala Asp 
     1170                1175                1180
Leu Leu Pro Pro Pro Pro Ala His Pro Pro Pro His Ser Asn Ser Glu 
 1185                1190                1195                1200
Glu Tyr Asn Ile Ser Val Asp Glu Ser Tyr Asp Gln Glu Met Pro Cys 
                 1205                1210                1215
Pro Val Pro Pro Ala Arg Met Tyr Leu Gln Gln Asp Glu Leu Glu Glu 
             1220                1225                1230
Glu Glu Asp Glu Arg Gly Pro Thr Pro Pro Val Arg Gly Ala Ala Ser 
         1235                1240                1245
Ser Pro Ala Ala Val Ser Tyr Ser His Gln Ser Thr Ala Thr Leu Thr 
     1250                1255                1260
Pro Ser Pro Gln Glu Glu Leu Gln Pro Met Leu Gln Asp Cys Pro Glu 
 1265                1270                1275                1280
Glu Thr Gly His Met Gln His Gln Pro Asp Arg Arg Arg Gln Pro Val 
                 1285                1290                1295
Ser Pro Pro Pro Pro Pro Arg Pro Ile Ser Pro Pro His Thr Tyr Gly 
             1300                1305                1310
Tyr Ile Ser Gly Pro Leu Val Ser Asp Met Asp Thr Asp Ala Pro Glu 
         1315                1320                1325
Glu Glu Glu Asp Glu Ala Asp Met Glu Val Ala Lys Met Gln Thr Arg 
     1330                1335                1340
Arg Leu Leu Leu Arg Gly Leu Glu Gln Thr Pro Ala Ser Ser Val Gly 
 1345                1350                1355                1360
Asp Leu Glu Ser Ser Val Thr Gly Ser Met Ile Asn Gly Trp Gly Ser 
                 1365                1370                1375
Ala Ser Glu Glu Asp Asn Ile Ser Ser Gly Arg Ser Ser Val Ser Ser 
             1380                1385                1390
Ser Asp Gly Ser Phe Phe Thr Asp Ala Asp Phe Ala Gln Ala Val Ala 
         1395                1400                1405
Ala Ala Ala Glu Tyr Ala Gly Leu Lys Val Ala Arg Arg Gln Met Gln 
     1410                1415                1420
Asp Ala Ala Gly Arg Arg His Phe His Ala Ser Gln Cys Pro Arg Pro 
 1425                1430                1435                1440
Thr Ser Pro Val Ser Thr Asp Ser Asn Met Ser Ala Ala Val Met Gln 
                 1445                1450                1455
Lys Thr Arg Pro Ala Lys Lys Leu Lys His Gln Pro Gly His Leu Arg 
             1460                1465                1470
Arg Glu Thr Tyr Thr Asp Asp Leu Pro Pro Pro Pro Val Pro Pro Pro 
         1475                1480                1485
Ala Ile Lys Ser Pro Thr Ala Gln Ser Lys Thr Gln Leu Glu Val Arg 
     1490                1495                1500
Pro Val Val Val Pro Lys Leu Pro Ser Met Asp Ala Arg Thr Asp Arg 
 1505                1510                1515                1520
Ser Ser Asp Arg Lys Gly Ser Ser Tyr Lys Gly Arg Glu Val Leu Asp 
                 1525                1530                1535
Gly Arg Gln Val Val Asp Met Arg Thr Asn Pro Gly Asp Pro Arg Glu 
             1540                1545                1550
Ala Gln Glu Gln Gln Asn Asp Gly Lys Gly Arg Gly Asn Lys Ala Ala 
         1555                1560                1565
Lys Arg Asp Leu Pro Pro Ala Lys Thr His Leu Ile Gln Glu Asp Ile 
     1570                1575                1580
Leu Pro Tyr Cys Arg Pro Thr Phe Pro Thr Ser Asn Asn Pro Arg Asp 
 1585                1590                1595                1600
Pro Ser Ser Ser Ser Ser Met Ser Ser Arg Gly Ser Gly Ser Arg Gln 
                 1605                1610                1615
Arg Glu Gln Ala Asn Val Gly Arg Arg Asn Ile Ala Glu Met Gln Val 
             1620                1625                1630
Leu Gly Gly Tyr Glu Arg Gly Glu Asp Asn Asn Glu Glu Leu Glu Glu 
         1635                1640                1645
Thr Glu Ser 
     1650



<210> 5067
<211> 459
<212> DNA
<213> Rattus norvegicus
<308> AA860044
<400> 5067

ttttttttt  tttttttgg  ggttgcgta  ctttattgt  tagacataa  tattttgtt  60
aaatattaa  cattaaacc  tttcctgac  tccagacag  aatagggag  gcaggaaca  120
caggcaaga  aagaaacag  ccactgaac  gacgtgtga  tcctatgcc  tccacagga  180
ggatttcag  atgggttca  aatgccaag  agctaagtt  ctaaaaaat  cacctctac  240
cagcataaa  ctctttact  ttttcccct  cacagagga  aagaaaccc  gaaactgaa  300
actgaaccg  ggtgatctg  tgcagacct  ttaccactc  acagccctc  ttacacatc  360
tgccatgct  aagagctct  cctgagaaa  taaaaactt  aaccctggt  attcccaaa  420
aacaccttg  gcctggttc  gtactaaag  gtcaagatt  459



<210> 5068
<211> 137
<212> PRT
<213> Rattus norvegicus
<308> AAH03203
<400> 5068

Glu Val Ala Arg Arg Arg Leu Gln Glu Ile Glu Asp Arg Ile Ile Asp 
  1               5                  10                  15
Glu Asp Glu Glu Val Glu Ser Asp Arg Asn Val Ser His Leu Pro Ser 
             20                  25                  30
Leu Val Leu Ser Asp Thr Met Lys Thr Gly Leu Lys Arg Glu Phe Asp 
         35                  40                  45
Glu Val Phe Thr Lys Arg Met Ile Glu Ser Met Ser Arg Pro Ser Met 
     50                  55                  60
Glu Leu Val Leu Trp Lys Pro Leu Pro Glu Leu Leu Pro Glu Lys Pro 
 65                  70                  75                  80
Lys Pro Ser Ser Ser Pro Lys Asn Tyr Arg Arg Glu Ser Gln Ala Lys 
                 85                  90                  95
His Ala Ala Pro Gly Thr Ala Phe Pro Gln Arg Thr Glu Gly Leu Leu 
             100                105                110
Glu Pro Gln Cys Ala Asp Ala Pro Leu Tyr Arg Ser Leu Glu Ala Ala 
         115                120                125
Thr Ser Thr Glu Glu Glu Met Glu Leu 
     130                135



<210> 5069
<211> 31737
<212> DNA
<213> Homo sapiens
<308> Z93930
<400> 5069

aagcttgtt  tgttttgtt  tgttttgtg  tttgagaca  ggtctcact  tgtcaccca  60
gctggagtg  agtggcatg  tcacagctc  ccacagcct  gacctcctg  gctcaggtg  120
tactcccac  tcagcctcc  gagtagctg  gactacagt  acctgctac  acacccagc  180
aatttttgt  ttttttgta  agacggggt  caccacatt  cccgggctg  ttgcaaact  240
ctgggctca  accatctgc  tggcttggc  tcccaaagt  ctaggatta  aggcatgag  300
cactgtgcc  ggcccataa  gcattatac  ttgtaccta  actaaaagg  atctgagat  360
ctttcagca  gtttgtcca  tgtttcctt  tcatttata  tgatttagt  tgagctagc  420
gcctacatg  aatattaac  acaacttaa  aaaatttcc  acaatcaag  gctctgcgt  480
ttcatattg  atttttaaa  acttccaat  acagcatca  tacaaccac  tgatttggt  540
aaatataca  gttgaagtg  gcaatgtta  gtatttgag  ggcctttct  aagatcagt  600
ggagccagg  atggtggta  gtgcctgta  tcctaatta  tgggaaggc  gaagtgggt  660
gattgcttg  ccccaggag  taaaggctg  ggtgagcta  gactgtacc  ctgtactcc  720
ctgtggaca  cacagcaag  ccccatctc  taaaaaaaa  aaaaaaaag  aagtaaaga  780
cagtttgtg  gttctaaat  tcctgtttt  ctatcatca  tccttaaga  actaggtaa  840
gttggcttt  caacctaca  cttttgttt  catgtccta  aattttttg  taaaagtct  900
tattttatg  cttaggagc  gtccttcca  ggagcttgt  ctctggaaa  ccctccctg  960
actcctttc  gataagcca  agccatcct  taatactaa  aactataca  gagagagcc  1020
agctaagca  gtagctgct  gcactgcct  ccctcagag  actgaactg  tttcggaac  1080
tcggccaac  gggatgtct  tttataata  tttggagac  gctactagc  cagaagaag  1140
gatggaact  tagaaacca  tttctacac  aaagttgtc  aatgttaga  gaatcctgt  1200
ttcagttat  agactcttt  catagtata  ggacttgaa  gttttatga  acgggtgta  1260
taatatctc  acctgtgat  tgggggtgg  actcttatt  tgggtagcc  tttattgac  1320
tcacctttt  gccaaggac  tttgtctca  gggaaaagc  gttttctgt  gggcttatt  1380
aaggaatgt  ggtttacat  gtcttcaaa  acaagtata  aagctgtat  tgtaagggt  1440
acttaaatc  tatgtcaca  tgtctaaac  attcagaca  ttggagaat  ttctccttg  1500
attaaaaaa  atgattaag  aggatgctc  tacaactgt  tcctgacag  taagtcaca  1560
cttaatgtg  agatatgag  tgtttacag  ggtgactat  tataattgg  gagaagaag  1620
gaagagagc  gcagtagct  aagcctgtt  ctaagaaat  taatttctt  gcaacttgt  1680
atttagtta  caattcaat  tagctctgt  gattaaata  ccgatagta  tgtggctct  1740
ctctttgac  atgaaaata  agagaaagt  ttttcttta  ggctttttt  ccttgtgcc  1800
ctgttgctc  ttggtttcc  ttgcgtaat  gataagccc  gttattcag  aatgtttac  1860
aattaattg  ctttgatag  taaaagatt  tgaggtaac  catctgcaa  ttgcctgtg  1920
gagaagcat  ctttagttc  tcttaagga  gtgctttat  agctaaacc  aacattgat  1980
actttggta  tttttttaa  aagttatac  tgtattagc  agttttttt  tttttcccc  2040
accgcaacc  ccatctccc  ggttcaagc  attctcctg  ctcaccctc  caagtagct  2100
ggattacag  tgcccacct  cacgcccag  taatttttg  atttttaat  gagaccggt  2160
ttgccatgt  ggccaggct  gtctcgaac  cctgacctc  ggtgatctg  ccaccccag  2220
ctcccaaaa  gctgggatt  caggcgtga  ccacggcac  cagccagca  gttgttttt  2280
aatgttaat  tagaaaaca  tgaaggatt  gctgaaaat  tatgagcag  tgacattga  2340
gtttactga  atagccaat  tgactggtg  ttagactat  gtgcagtaa  cctaaaagg  2400
agtggagaa  tgcttcctg  tagcaggaa  ccttcatct  cttgagtac  caaaccagg  2460
ttcaggtgt  ctttgagga  agccaggtt  gaaattttt  gtttctcag  aagagctct  2520
ctatgtggc  ggggctgat  gggcaaaat  aaatgacaa  ttctttatt  ctacagagt  2580
tcctctata  gttattaaa  gagtgtaat  gtataatgc  cttccatca  acaacagga  2640
accacccca  ttttgtttt  tgggtttct  ccccctttg  aggaatcag  taccttttg  2700
agaaaaaaa  ggcttatgc  acgtaaagg  gaattttta  aaaccacct  ctaggcgtt  2760
ttggaaccc  tactgaaat  cctcccctt  ttacagatg  cgtagaagt  acaagtctg  2820
taattggac  gttgcttct  tgcctgttc  tgctttctc  ttctgtctg  atagtcagg  2880
aaagattta  tgtttaata  ttaaacaaa  tatttaatg  ctatacagt  aaattattc  2940
aacttcaaa  cagtattga  agcagttgg  aaccagcta  tagtttctt  atctcagat  3000
tcgagatga  tgtaaactg  attcttttg  aatgtgcaa  tgtttgatt  atgccattt  3060
ataaacttc  gccttgtag  cattgtttg  tgggaccaa  ttgtaaagt  tgagcctta  3120
ataaatctc  atgctgaaa  atgtgttct  atgcaacac  aaaacatga  gtgactgcc  3180
agaggtaga  ttagtgttt  ggtggaaag  gagatgaca  ctttccaaa  aaggaccta  3240
aacacacca  gattgtctt  tacaggaat  gctgggcag  tctccgact  aaggtctta  3300
gatgaaaag  aagaaacaa  cccccaaca  aaggctctg  tactactgg  aaatgtagg  3360
gagaattaa  aatctgtta  ttaaaatcc  aacagagct  atttcagta  tcaagttac  3420
tgacatgat  attatttct  caggataat  gatgtttta  gttcttttt  ggactttat  3480
ttcttgcaa  aatttctac  aaaattgtt  tcttcatcc  tgtggtgct  attcatctg  3540
gccgtctcc  cagtcccaa  gcctctgct  tttgtttta  ttttgtagc  taaggtttt  3600
gcttttgct  tgccttaag  gttccctag  gagttacca  ggcttttcg  tttgtgtag  3660
ttttgcagc  tggatcaaa  attggctta  tgtgctaat  tgtgaagag  aaaaattct  3720
taaagcagg  gagctttaa  gaacaaatg  gtattttat  tgagtttga  tagggtgcg  3780
tgtggattt  gttttttgg  ttttttttt  ttttttgta  ttatatgaa  aaagtccag  3840
tctcataaa  attgatcac  taaaaaact  actctttct  gaaaaggta  acatgtaaa  3900
tttaggaaa  taactaaag  aggggctgg  accataaga  gaatgttta  cagcacgtt  3960
atttattat  ttggatttg  aacttggct  tgtttttca  tagtgacaa  aatggttca  4020
ttctaggaa  gttctggaa  atgctgtta  ttttacttt  aaatgagaa  ctggtgtta  4080
tgtatttta  cgttttcaa  aaaacttct  aagtgtttt  gacttttga  atatttgta  4140
tactccact  aaataatga  atcagatat  tcctttcct  tgaattgta  ttgaagcag  4200
attcatatc  gtgaaggac  taaatttat  ctgaaggga  gattatgtt  ggataaagc  4260
aagtatcat  tttgaatta  ctgttccca  aataggcag  ccatgtgtt  ctattctaa  4320
acccataga  tgctttcca  tcagagcag  tcactgcta  tgttagtat  tagatggca  4380
tggtaactg  gtattcaaa  atgttaaaa  gggctaggt  cgatggtgc  cacctgtgc  4440
agcactttg  gagactgag  caggaggat  acttaagct  aggagagac  agcctggac  4500
atattagca  gaccttttc  cttaaaaaa  aaaaaaaag  atatatata  atattcaaa  4560
gtagagttg  aagtggcat  cagagttca  agagagggg  ttgaggatc  ttgaaaatg  4620
ggaatggaa  acccagtga  gttcactta  atggtgttt  ctttttttg  gtgtgagac  4680
gagttttgc  tgttgcccc  gctggagtg  aatggcgtg  tcttggctc  ctgcaacct  4740
tgcctcccg  attcaagca  ttctcgtgc  tcagcctcc  gagtagctg  gattacagg  4800
atgcgccac  acacctggc  aatttttgt  ggttttttg  tgttgttgt  gttgttttt  4860
agacggagt  tcgctgttt  gccaggctg  agtgcagtg  tgcaatatc  gctcgctgc  4920
acctccgcc  cccaggttc  agcgattct  ctgcctcag  ctcctgagt  gctgagact  4980
taggcgcga  ccaccatgc  cagctaatt  ttcttgtac  attagtaga  atggagttt  5040
tccgtgttt  tcaggctgg  ctcgaactc  taacctcag  tgatctgct  gcctcggcc  5100
cccaaagtg  tgggattac  ggtgtgagc  accatgccc  gccgtttcc  ttaagactt  5160
acaggtcac  gggtggcag  attgcctgc  tatttacat  ctttgataa  tgcattcct  5220
atttggtgg  caggaggag  taagtttgg  atacaacta  aaaaagcaa  gcatggtgg  5280
ttttttttt  agatggagt  ttccctctg  tgcccaggc  ggagtgcag  ggcacaatc  5340
cggttcact  caacctctg  ctcctgggt  caggcgatt  tcctgcctc  gcttcctga  5400
tagctgcga  taccggcat  tgccaccac  cccagctaa  ttttgtatt  ttagtagag  5460
cggtttcac  atattggcc  ggctggtct  gaactcctg  ccttgtgat  cacccacct  5520
agcccccca  agtgctagg  ttacaggtg  gagccactg  gcccggctg  atgatgttt  5580
gtttttaat  aaaatttgg  aatcacagc  aaaaatgat  taattacag  tttggaaac  5640
aaagcctaa  tagatcgtg  catcctgtt  ctcgggtca  tgttctttc  acttgacca  5700
ttggtttta  agtctttgc  gatctaaga  gtcatttag  ttttgttga  ataactgat  5760
atatagttc  agcagtcta  cattaaact  cttgaggaa  catggttta  tatgtatca  5820
tttggtaca  atcctatag  tgtgttaat  ccctagttc  tcagactac  agtagcatc  5880
tagagatga  gtagttgta  ttagaacag  gtttggatt  tagctccag  aagacaatg  5940
tgtttggtt  ggtgcagtg  ctcatgctt  taatcccag  attttggga  gctgaggtc  6000
gaaaattgc  tgagtccac  cgtttgaga  cagcctgga  aacacagtg  gactctgtc  6060
ctataagaa  tttaaaaat  aggtgtggt  gctgttccc  gctactcag  aggctgagg  6120
gggaggatg  cctgagtcc  ggagttaga  gctgcagtg  gccatgatt  cgccattgc  6180
gctcagctt  agtgccagt  agaccctgc  tcaaaaaag  ctgatgttt  ccttcaaca  6240
ctggttggt  gggtaaaca  gccagtctt  ctattgctt  ttttttttt  atgtattta  6300
tttttagag  tggggtctt  ctttgttgc  cagccggtc  cgaactggg  tcaagccat  6360
ctcccacct  agcctctca  agtgctggg  ttatagacg  gaagcaccg  gcctggccc  6420
gtcttcctg  ttcttaatg  actttatgt  ataagagaa  tgaattctt  ggagactgg  6480
acgtgactg  ttattttaa  gtgtgcctg  agtaagcag  attaccttc  gcctacagt  6540
ctgtcccta  tttctctct  ctccaataa  atatctagt  gaaaagcaa  gagggggcc  6600
ggtgcagtg  ctcacgcct  taatcccag  attttgtga  gctgaggtg  gtggatcac  6660
tgaggtcag  agtttgagt  cagccaggc  aacgtggtg  aaccctatt  ctactaaaa  6720
tacaaagat  agctgggtg  ggtggcatg  gcctataat  ccagctact  aagaggttg  6780
ggcagaatt  cttgaaccc  ggaggtgga  gttgcagtg  gccaagatc  tgccactgc  6840
ccccagcct  ggcgacaga  cgaaactca  tctttttta  aaaaaaaaa  aaagagaaa  6900
agattggtg  gacagggcc  agggaaatg  catgcaggc  tcttaccac  tgcctcttc  6960
atctgagac  accctctgc  tttaatgga  ctctggctt  ggttttgtg  gaatatctt  7020
atttttggt  ctaaccatt  aatttggtg  ttcagtatg  aaatgtcca  gaataccag  7080
tgttttctc  aggctgttt  gtaatttcc  cccatctgt  caggaaatg  aaaccctga  7140
aatttacac  ggttatata  gtcctgtcc  gttagtaca  ctgcctctt  catgtggta  7200
cattgaata  aaataactt  agcctcaac  tccagatgc  tgtgctata  tgatagagg  7260
taaagtaca  ctgtaatta  atctgccta  acaattcct  aataggttc  tggccctaa  7320
gtttgcaga  ttatagaaa  tcaggtgag  taaagtttt  aatcatggg  tcagctgga  7380
gctgttctt  tatacagaa  ctttttttt  ttaggcagt  ttgcttttt  acccagtct  7440
gagtgcagt  ctgcgatct  ggctgactg  aacctctgc  ccctggcct  aagcgatcc  7500
cccacctca  cttcctgag  ggctgtgac  accagtgca  accaccatg  ctggctatt  7560
ttttttact  ttcatggag  gacgggttt  ccatgttgt  caggctagt  ttgaaccaa  7620
caatctgct  gcctcggcc  cccaaagtg  tgggattat  ggtgtgagc  accatgcct  7680
gcctgtttc  gaagaaact  aagagccta  gcaagtttg  attgctgag  accaggatt  7740
ggccctggc  tcaacgacc  gatcttgaa  gcagctagc  gacttgcct  cagtcacta  7800
atgaaaggc  ttctatttt  ttttttctt  tttaaatgg  gtttcgctc  tgttgccca  7860
gctggagtg  aatggcacg  tctcggctc  ctgcatcct  tgcctcccg  gttcaagtg  7920
ttctgccgc  tcagcctcc  gagtagctg  gattacagg  atatgcgcc  ccacaccca  7980
ctaattttg  atttttact  gagatgggg  ttcactatg  tggtcaggc  ggccatgaa  8040
tcctgacct  aggtgatcc  cccacctca  cctcccaaa  tgttgggat  acaagcgtg  8100
gccactaca  ctggcctac  ccaaaggta  tctataatc  actttgcct  gctgcttgg  8160
attctctga  tcctgcctt  tttctactc  ttcactttg  cctccccag  gttagtctt  8220
gtaagttgg  aacatagca  ttaaatgct  aattggcat  gaatgattt  atctactgg  8280
ataggtgaa  tttttataa  taagtaaag  cctgtaaaa  cttgtaaga  ttccaagga  8340
aagatgcta  gaaggatga  gaggttatc  agtctttgg  agttgtatt  atatcacta  8400
gattttttc  tgaagaggt  tatttattt  tttatttat  tatttattt  ttttttgag  8460
cagagtctc  ctctgttgc  caggctgga  tgcagtggc  cgatctccc  tcaccgcaa  8520
ctccgcctc  cgggttcac  ccattctcc  gcctcagcc  cccaagtag  tgggattac  8580
ggcgcccac  accacgcct  gctaatttt  tgtaatttt  gtagagaca  ggtttcccc  8640
tgttaggca  gatggtctc  atctcctga  ctcgtgatc  acccgcctc  gcctcccaa  8700
gtgctggga  tacaggcat  agccaccgc  cctggccga  gtttattct  tgatgaaac  8760
aattcttga  taaatataa  tctggaaga  attaaaacc  ttccaaagt  gattaggag  8820
taataacta  ctaactttc  agtgtttag  atggtgcct  gcatatact  aatgcttat  8880
atgcatcgt  tctttgaat  ttaaccttt  gagatacca  tatccaact  tacagatga  8940
gaaataagt  attatatat  acccctggg  tacccagct  accagtggc  gagttgaaa  9000
tagggagtt  cagtctaga  aatgctctt  attcccata  taagggcaa  agaatctcg  9060
tatgtgatg  tgtgtcctt  tttaacatt  ataagatgg  gtagcaaat  gtggttagg  9120
ttctagctc  tccacttac  agctgtgat  ttggtcagt  aggctcaag  atctgtctc  9180
gaaagacag  aactgctca  attatagct  atatcactt  tggcagtcc  gaattaaag  9240
aggcagtaa  taaggtgga  aagccttca  tcactttaa  aagcgttag  ctcacttca  9300
ttggattaa  tcctaccac  gcacacaga  aaacatctg  agagaaaac  agacttacg  9360
ccctagaag  aatcaaaca  ggatgctgc  ttgtacctt  taattgcat  ggtagtttt  9420
aataaatgg  gaaagcacc  ttcagaagc  acactagca  gaaaaaatt  catcaagca  9480
ttacatagt  aatttctat  atttcacaa  agattcttg  tcttacttg  agtatacat  9540
agggaaaga  ccccctcag  aggtgttcc  gttgcttac  gaagcaaac  aaaggacct  9600
aaactggag  caagccagg  tgccaaaaa  ggggaagag  aatgataaa  aaccattca  9660
aaattccat  tctacttca  gacatttgt  taatgaccc  tacataata  gtattttag  9720
gaaaactac  accctttta  gataaaagt  caatcttaa  agctgtagt  ctcaattat  9780
gtaatattt  ttacttcca  taatatgtc  caatacctt  gactgctgg  tgtcaaaag  9840
caatacctg  gggtcatct  tgagatctg  acaaataga  gaattctct  ggactgtat  9900
ctctctatt  tggcttttt  aatgaagta  agacaggct  ctctgctat  ctccaggca  9960
tgtaatagt  aaggaaaag  gcaacagta  tggatcatt  cttagacac  aatcagctg  10020
ggaaagagt  cattggcaa  agtgtcctc  caagaatgg  ttacaccaa  cagagagga  10080
atgtcactg  atggggaaa  ggaaccccc  tatccacag  cactgtaag  atccagtag  10140
caggaagat  gctttgggc  gtggctgga  gaaagcaga  ttgagatac  cagctccgg  10200
acgaggtca  cttctacag  ttcttcctt  actgagaca  tgaattcag  gtgatcatt  10260
tctgagggg  tgagaggtg  ttcctcgat  ttcactacc  cattagctt  gctctctgt  10320
tcagagggt  tctctaaga  taggggctt  gtatatatg  ggtcaaaac  aattagttc  10380
ttaatggct  ccagcttgg  tgatgacgt  cccactgac  gagaaaggg  ggctggtaa  10440
gaactgggt  cttctgggt  gacctctgg  agctcctcc  ggctggcag  ctctgggga  10500
gggcatttg  agaacatga  tgggtccaa  ttgtccaga  tgcccaaca  gatatcaga  10560
tgtaagagg  aaaaattaa  tgaagtaca  ctgtcagaa  acaatggaa  atctaactg  10620
aacactttg  actgggttc  ataatgtaa  ttagtcatt  tgtgataag  tgacctcgg  10680
acccaccag  cccatttat  tacacttca  tccatgttc  atattacct  gaactagga  10740
ggtagttga  gttcacctc  aaccccacc  aaaactaac  tcaaccctc  tctgtctag  10800
tagggatgt  aagcatcaa  cagatggaa  taactggtt  tatagctct  taataagtc  10860
gaatgatcc  tacctctga  tctgaagag  caataccgc  agaatccat  gggagatgt  10920
ctggagggg  gacaactgg  cctgcacct  ctgcagagg  gcacgtagt  tgagtgctg  10980
ggactcagc  gacccggcc  ctggcctca  ttcattccc  tgggaggaa  gaccaaagt  11040
aataaacag  ttcaagtgc  caaggaaat  cttgctaga  agctgtgat  ctcaacttt  11100
aagaattac  tttcaaaaa  attctaggg  taaattgct  tagaacttt  ttatctaac  11160
acattatta  tattgagaa  agcaagata  gatatttgc  agttctgct  gaatctttg  11220
ctggaggag  aaaaatgtt  cattgtgca  gaaatgtat  aggaagcct  acctccctt  11280
tctcatctc  tgaggactt  aaagtggaa  taacaatgg  tagggaaag  tttcagctg  11340
aaagaatgg  tttctagtt  tcttgaaat  tgtcctgaa  attaccttc  cagagtaaa  11400
ctgtgctac  gtcaatctt  gaccatttg  ttgttgtca  tgaatttgc  ataatctgt  11460
gactaaaac  cacatacca  ccttctctt  ccacagagg  atcactatt  caaagaatc  11520
tttccctac  cattcatat  catcaaaga  ctactttaa  tttagtagc  ttcaaaatc  11580
ggtttgagt  gctctctta  tttggttct  cttaatgat  gcatggtaa  cttgttggc  11640
actgcattt  ttagtactt  ttcttaggg  gccatgtaa  ttgttttca  tattagatc  11700
tagtactgt  cactacaca  ttaaaaaat  agtgtcaag  gcctttagg  gaagaacac  11760
ctgcctgca  gaaaatgtc  taaaactga  ggaaaattt  aagaacgct  ttgatcaga  11820
gtccagact  taaacataa  cgctgggtc  tgtcacttg  aaccagtac  cacatgagg  11880
accaaataa  ggagatgat  taccttggc  tccgcctcc  cttcagcaa  cagggcatc  11940
atccccaag  gctgtctta  ctcctggtt  tcaactaca  ggccatgag  tttctctcg  12000
aaaagctga  tttctagca  aagtttttg  ttctggaag  aagttcata  gaggctatt  12060
aaacatcta  ttatttcag  taagaatct  cctgattca  tataattgg  ttcctttcc  12120
tcttgaact  ttggaaaac  ctatgcttg  ggtgttcat  gtaggtttt  aaaagctag  12180
ccataatta  ggaaaagca  gctacttaa  aagtgccac  tcatggggt  aagaataac  12240
cactgcttc  aactactaa  actgacttc  gcaaagggt  acttgtggc  ttaatgtag  12300
tataatttt  tttttaaac  atcttggcc  ggctcggtg  ctcacactt  taatcctaa  12360
actttggga  gccaaggca  gtggatcac  tgaggtcaa  agttcaaaa  cagcctggc  12420
aacatggca  acccccatc  ctactaaaa  atccaaaaa  tagctggat  tggtgaggg  12480
tgcctgtaa  cccagctaa  ctggaggct  aagcaggga  aattgcttg  acctgggag  12540
cagaggttg  agtgagccg  gattgcacc  ctgcactcc  gcctgggca  cagagtgag  12600
ctccatctc  aaataatga  gatgataat  ataataata  taatataaa  taaaaataa  12660
taactatct  gaactggca  gtaataata  aagtggtag  ggtgactat  aatccaaaa  12720
aagttaaaa  aaatccctg  tcctgactc  tgattctta  aagaaccaa  taatgatta  12780
aactttaaa  agctcaata  atgcaaatt  accaagggg  taaaaaaac  atataaata  12840
tctctatgt  ttcaagatg  gtaattggc  acaatttaa  attgattaa  aggtggacc  12900
tagaggggg  aaggaacct  tagtgaatt  ctggccatg  caggaagaa  gtaaagttt  12960
agcaattat  tcctattag  ccttgctaa  ttcttacta  aaactcaat  aacattgtt  13020
aatccatct  ctttgagat  catctagca  caaatgcca  aaagtcaat  acttctgcc  13080
tcaacaagc  tcaccactt  accaactct  tgtcctaac  tagattaac  ttttttttt  13140
ttttgagac  gggtttttg  tctgtcgcc  agactggag  gcagtggca  gatctcgtg  13200
tctcagctc  ctgcaacct  cgcctcctg  gttcaagtg  ttctcctgc  tcagcctcc  13260
gagcagctg  gattacagg  gcctgccac  acacccggc  aatttttgt  tttttaata  13320
agatggggt  tcaccacgt  ggtcaggct  gtctcgaac  cctgatctc  agttatcta  13380
ccaccttgg  ctcccaaag  gctgggatt  caggtgtga  ccccggtgc  cagcaaact  13440
ttttttttt  tcttgagac  gagtctcac  ctgttgccc  ggctggagt  cagtggtgc  13500
atctcagct  actgcaacc  ccctctccc  ggttcaaac  atcctccca  ctcaacctc  13560
cgagtagct  ggactacag  cactcacgc  tggcctttt  ttttttttt  tttttggta  13620
atttttggg  agagacggg  ttttaccat  ttggctagg  tggtctcaa  ctgctggct  13680
caagtgatc  gcccaactc  ggctcccaa  gtgctggga  tacaggcat  agccaccat  13740
cccagccta  tttaacttt  aatcatata  tcaattgta  tctaatagg  gctgaaaca  13800
cttgggatg  gaagcaaat  tcagaacat  caccaagga  gggtataca  tggataaaa  13860
agtttgacc  taagtagtt  tacctcttc  tctaaatct  ccacttgct  ttccagctc  13920
ctcattcga  ccttctttc  atctctggc  gtctgagct  ctactctgt  tttcagttt  13980
ctaggaaga  aaggaacat  ccacactga  tcatatcaa  ccttattta  gtctttatt  14040
gaaaacttt  ccagctggt  ctttcattt  tatttacag  ataagacag  ctaatgata  14100
aatacactt  aggctcctc  cctcaataa  acaaaataa  aaatacagt  ttctgtcaa  14160
ctagctcga  gacctgctt  attctctcc  atattgcat  atccgtcca  ctcagactc  14220
tccccgtca  agcactggg  ctggacaca  acactattc  tcttgcatc  taaggaact  14280
tcctctttc  ccatctatt  ccccgctgc  tcctgtctc  agttctctt  aacaggatc  14340
aacctggcc  cattaatct  gtgaaggct  caatcttgc  atgacatca  ccctccgtc  14400
cccagtcca  tttagaaaa  ggagaggct  atgccactc  ctgatctct  gtgttgaga  14460
cctaggcag  gacctgctg  tgggtccgt  tctgttgga  gagacactt  tttttttaa  14520
agaattaac  cagaagaga  acttcataa  tcacagaag  cacaatgat  acaaaagag  14580
gaacattta  ggaggacta  gtgctaggc  cattatatc  aagtctcaa  ctccccaaa  14640
acctcatga  gtaggttcc  ttttaagaa  gcagatact  agctagacc  gtgagcctc  14700
cagaattcc  agccctttc  acagctctg  tatttcagc  ccgcgcctc  ccagaaata  14760
cagtaaacc  aaacagatt  ttcgacctc  tgtccgagt  aagaggctg  accaccagt  14820
tgcggccac  cagcaagag  gcctggaag  caggtgccc  catccccag  tctggtcat  14880
tctaacgag  gagttaaaa  gtacagaaa  gagccctgg  ccgccctag  ttcccagcg  14940
ggcggatcc  gtcagtccg  gcttcctgc  ccgccccgc  ccacgctgg  accgacccg  15000
caggccaaa  gcgacggag  cctgcgggg  ggccagtgc  gggtccccg  tcccagccc  15060
tgcccctgc  cctgtccct  gtcccggct  cagatctgg  cccagaccc  ggcccctcg  15120
ccacctcct  agcgccttc  cctcggggc  caggtgcgt  aggcgctgt  gcttgcgcg  15180
ctggggcag  cccccgctc  ctgcctccg  gctggcccc  ctctgggct  gcaccatga  15240
cggcagggc  tggccggcc  gggctccgg  ggcggaggc  ggctgcccc  acagaagca  15300
aactttagg  gtcccgtcg  ccgggttcg  cgcggctgc  accaccacc  tagctccag  15360
ctacgcacc  cgcaccgcg  gccgcagcc  cccagcgcc  agcctcgcc  cgcccggcc  15420
ttctacggt  gtggccctc  gcgattggc  agcgtcgcg  gacgcacgg  cgagctcgg  15480
gtccattgg  ccggcctgc  cggcggggc  tttcaggac  gtggctatg  agtccggcg  15540
ggcagcggc  atccctggc  aaaggtact  ggggtcatt  tccgcgggg  gttacgtgc  15600
ggagcgtgt  ctccacaaa  ggattttcc  cccttaagc  gacttattt  catccggag  15660
gacagaatt  aattccaaa  cgagagctt  ccagactga  gaattttta  cgggactaa  15720
agagaatta  ctcagcctg  caacatttt  tctcgtgcg  cacttcggg  tccgagtgg  15780
gccgaaagt  gagatagag  gcagttggg  cttgggttc  aaaagactg  acagaggtt  15840
cagtgagcc  agatcgcgc  actgcaccc  ggcctgggc  acagagcga  actccgtct  15900
aaaaaaaga  aaagaaaaa  gcctggaaa  aaattctgc  gaatagaag  ctttaagaa  15960
tgagatcgt  ccctttaaa  ctaagttta  caatagtga  ggcttaata  acgataggt  16020
ttatctctg  gttggaggg  aataccttc  attttagtt  ttcgttcca  ttctaaagt  16080
tgtactatg  gcgtgcatt  ttttaaatt  agttttatt  tatttttta  atagaaacg  16140
ggtctcact  tgttgccca  gctgatctc  aacttctga  ctcaagtga  cctcccgct  16200
cggcctcta  tatttttat  ttatttttt  ttcttattt  ttgagacgg  gtcaggctc  16260
gtcaccagg  tggagtgca  tggcgagat  tcagctcac  gcaaccttc  cctccgggt  16320
caagcaatt  tcctgcctc  gcctcccga  tagctggga  tacaggcgc  cgccaccac  16380
cccggctaa  tttttgtag  ttagtagag  cggggtttc  ccgtgttgg  caggatggt  16440
tccatctcc  gacctcgtg  tcgcccgcc  cggcctccc  aagtgctgg  attacaggc  16500
taagccact  cgcccagcc  cttgttatt  taaatgagg  gacaggaaa  cgtcacatg  16560
agagactga  accccgggg  tgaccctga  ccccctctc  gaggggagg  cgaggttcc  16620
gcctggcca  tgtggcgtg  gggtggcca  gtgtttgtg  aagaggggc  cccagagag  16680
agcacggga  cgatttata  acacgaata  taacatgga  aagtccgag  aacccccgt  16740
aatatgcct  tccactttt  ttaaagcaa  ttacaaaat  tgaaattcc  cagaaatgc  16800
cagcaatac  ttctctaac  agtaattat  gcttcctcc  ctgcgggca  cactattcc  16860
ggttctagg  gtgcaaaca  tagtaagac  gctacctgg  atttggagg  tatgcaaaa  16920
gtgaaatgt  aagatagca  gttcctaag  aattcttta  tgttattaa  tcggattag  16980
tggtcaatt  tattttggt  gggagggaa  aggatggga  aaagaacta  aagcaagtc  17040
atctcttga  atctaagcc  tctaaaggg  catagtttt  gtttttgcc  ggactgggc  17100
acgagtctc  taacgtgtt  tctccctct  cgttgggag  gaaatcaat  atttttttt  17160
ttttaactg  gctgtccca  ctccagagc  tcctgagca  gtgctgtcc  gtgggttgg  17220
aaagaggtg  gggtgattg  agtctctgc  ggaccaaga  accaacttc  tgtttaact  17280
tcatcagct  gggccacct  ggttctgat  tgccttcag  tgtggggag  cttactccg  17340
gcctctgaa  tgttttggg  gaagtctgg  ggtgtcttc  agccgagac  tatagcttc  17400
tattaaaag  ccttggaaa  ctgtaagag  ctgttagaa  agtcatgtc  tgtcatgcc  17460
cctgttacg  tttattttt  gatgccttt  ttttccttt  ttttttttt  gagactggg  17520
ttcgccacg  tgcctaggc  ggaactcct  ggctcaagc  atcctcttg  cttggcctc  17580
caaactgct  ggattgcag  caggaacca  agagcccgg  cctttttat  tattaagtg  17640
acatttatt  atgccaaga  aatgtcttt  actgtgtaa  aaagaaaat  ctggaggac  17700
cttttagtc  agcagggtg  agtgagtaa  tgagtagag  aagcacagg  tgcgggatg  17760
ggaaaaaag  ttgatgaat  gcactttga  cttagttaa  gcgatattg  aattcactt  17820
cccagcttg  tttcaaaac  tttatattt  tgacaaaca  tttaaatca  actaaaaac  17880
ataatttga  ccactacag  ttgctgtcc  tgcagtctt  aacatgtga  tccaaaccc  17940
tggacagtt  catatcctc  ctataaaat  aacctggta  ttcttgcat  aggtgccat  18000
agtgtttaa  aatatttac  agacacctg  gataagagc  ataaaatat  taaattaca  18060
agttctcgg  ctttgaggc  aaacgcggt  gctcacccc  gtaatccca  cactttggg  18120
ggccgaggt  ggcagatca  ctgagatca  gagttcgag  ccagcctgg  caacatggt  18180
aaacccagt  tctactaaa  atacaaaaa  tagccggac  tggtggggg  cgcctgtaa  18240
ctcagctac  ggggaggct  aggcaggat  atgtcttga  cctgggagg  agaggttgc  18300
attagccaa  attgtgcca  tgcactcca  cctggtcaa  agagtgaga  tttctcaaa  18360
aaaaaaaaa  aaaaaaaaa  agtcattat  cagaaagaa  cagtcagga  agggtggac  18420
aaacaggaa  agaaataaa  aggcattcc  gaaaaggga  aacagaaaa  tactgtaca  18480
tggtaagca  aaaacagaa  ataacatgg  aggaataag  ccaaatata  aaataataa  18540
acataaatg  gaatgggtt  tattatctt  ttaatcatg  tgttttgtt  tatgtatgt  18600
tctttataa  caacatata  ctggctttg  ggtttctca  agctctctt  taagaagag  18660
atataaatc  tttgtattt  tttttgatt  tttatttat  tggacttat  tctgccatg  18720
tatttcaca  tttttgttt  ctatatttc  caaggcagg  ggattgctt  aggccagga  18780
ttcaagacc  ggctgggaa  catattgtg  ccttgtctc  acaaaaaat  taaaaaaat  18840
aaccaggcg  ggtgacttg  acctgtagt  ccagctgct  ggaagacgg  ggtggtaag  18900
tcccttgaa  ccaggagtt  gaggctgca  taaactatg  gctatgatt  aaccattgt  18960
ctccaacct  ggagacaga  tgagctcct  cctctaaaa  acaaaaatt  ttttaaaaa  19020
aaggaaaat  acttaccag  catttttat  tttatggaa  tgtttatgg  aagaaagca  19080
atgtagcaa  attaatatg  gacagaatt  atcataaag  cattaaaag  acaaagaag  19140
gtatttcat  ttgattgaa  gtacaagtt  ccatatata  atctttatg  acatagcaa  19200
ataattttg  aatgtatag  cctagcatg  cggctcaca  ctgtaatct  agcactttg  19260
gaggctgag  tcaggggtt  aagaccagc  tggtcaaca  ggcgaaacc  cgtctctat  19320
aaaaataca  aaattaact  ggcatggtg  cacgtgcct  taatcccag  tactgagga  19380
gctgaggca  gagaattgc  tgaacacgg  aggcagagg  tgtagtgag  caagatcga  19440
ccactgctc  ccaacctgg  tgagggaca  agcaagact  tgtctcaaa  aaaaaaaaa  19500
aaaaaaaaa  ttagctggg  ttggtagtg  gcacttgta  ccccagctg  tcgggaggc  19560
aaggtggga  gatcatttg  gcccagaag  ttgaggctg  agtgagccg  gatggtacc  19620
ctgcattca  gcctgggtg  cagagtgag  tcctgtctc  aaagaaaaa  caaaagaaa  19680
ttggctggg  acggtgact  atgcccgta  tcccagctc  ttgggaggc  ggggcgggg  19740
tcccctgaa  tcaggagtt  gagaccagc  tggccaaca  ggtgaaacc  tatctgccg  19800
gaccagctc  gtcagggag  ccctaaccc  gcagtgcta  aggaattaa  gacacacac  19860
cagaaatat  gaggtgtga  gccgggcgc  gtggctcac  cttgtaatc  cagcacttt  19920
ggaggccga  gcaggcgga  cacgaagtc  ggagatcaa  accatcctg  ctaacacgg  19980
gaaaccccg  ctctactaa  aatacaaaa  attagccgg  cgtagtggc  ggcgcctgt  20040
gtcccagct  ctcggaagg  tgaggcggg  gaatggcgt  aacccggga  gcggagctt  20100
cagtgagca  agatcgtgc  actgcactc  agcctgggc  agagtgaga  tctgtctca  20160
aaaaaaaaa  aaaaaaaaa  gaaatatag  ggtgtgaag  gggaaatca  ggatcttac  20220
accttcaga  ctgagaacc  tgaacagag  tttacccac  tatttatta  cagcaaacc  20280
gtcattagc  ttgtttcta  agatattaa  ttaactaaa  gtatccctt  agggaaacg  20340
agggatggg  tgaattaaa  aaataggtt  ggctagtta  ctgcagcgg  agcatgctc  20400
taaggcatg  attgcttat  ctattgttt  tggcttaag  atgccttta  gcagttttc  20460
gccctgggc  ggccaggtg  tccttgccc  catttccgt  aacccacag  cttccagct  20520
gggcgttat  gccattatg  acatgttac  ttgctgcag  gattttatt  atggccagt  20580
ttggggcca  tttatgacc  gactttggg  ggcttgctc  caacagcta  ctctactaa  20640
aataacaaa  attagctgg  cgtggtggt  ggcgcctgt  atcccagct  ctcaggagg  20700
tgaggcagg  gaatcactt  aacccggga  ggggaggtt  cagtgagcc  agatcgcac  20760
attgcactc  aacctgggc  acaagagtg  aactctgtc  caaaaaaag  aaagaaaag  20820
aatgtataa  acaaagact  aaatgatga  aatgatcca  aaatcacaa  gggagataa  20880
tacaattct  agaatcaac  gagggagca  acagaaaaa  tttgaacag  acaactttc  20940
tcccaacca  ggacttatg  tttttcttt  tttcgagac  gagtctccc  ctgtcaccc  21000
ggctggagt  cagtggcgc  atctcggct  actgcaaac  ccgcctcct  ggttcaagc  21060
attctcctg  ctcagcctc  cgagtacct  ggattacag  cgcctgcca  catacccat  21120
taatttttg  ttttttagt  gagacggtt  caccatgtt  gacaggctg  tatagaact  21180
ctgaccttg  gatccgccc  cctcggcct  ccaaagtgt  gggattaca  gtgtgagcc  21240
ctgtgccca  acaggccta  gttttttca  ttaagaaac  ttctcactt  tttttttct  21300
tttgagatg  aatctcgct  tgttgccca  gctggagtg  agtggcacg  tctcagctc  21360
ctgtcttac  gcaacctcc  actcttgat  ctcctgcct  agcttcccg  gtagctggg  21420
ttacgggta  aagccacca  gcctggttg  tttttgtat  tttagtaga  acagagttt  21480
accatgttg  ccagcctgg  ctggaactc  tgacctcag  taatccacc  aagttgggc  21540
cccaaagcg  tgggattat  ggcgtgagc  acgggacct  gcgaaatct  tatattttc  21600
tttctctta  gtaaatacc  ataagtgga  ttgcagtat  atatggtaa  tactatgtt  21660
aaatttttt  gaaacttag  agctttcca  agtggctat  ggttatacc  ttttacatt  21720
ccaccagtg  tgtactgct  ttttatatt  ctattatag  ttgttattt  actctttca  21780
ggttgtcca  cttcttatt  tttatgttg  atgtttttc  caactggat  tcaacaagc  21840
cattagacg  agaagctag  gttattcgt  gttccattt  ttgtgtgtt  tgtgcttac  21900
atagtgctg  gtacatact  ggcattcaa  aaatatttt  gaatgacta  tgaatggtt  21960
cattatctg  aatatgctt  attttattt  attatattt  gagacaggg  cttactctg  22020
cactcaggc  gaagtgcag  ggcatgatg  cggctcact  gagctttcg  ctcccgggt  22080
caaatgatt  tcccgtctc  gcctcctaa  tagctggga  tacaggcat  caccatcat  22140
cctggctaa  ttcttttgt  tgtttgtat  tttagtaga  acggggttt  gttacattg  22200
ccaggctgg  ctcgaattc  tgacctcag  tgatctacc  gcctcaccc  cccaaagtg  22260
tggaattac  ggcatgagc  accgctccc  gctgaatga  ctcattttt  ttttctttt  22320
ttgagacgg  gtctcactc  tgttgccca  gctggagtg  aatggcgcc  tctcagctc  22380
ccccaacct  tgcctcctg  gttcaagcg  ttctcctgc  tcagcctcc  aagtagctg  22440
aattacagg  atgtgccac  atgcccagc  aattttgta  ttttagtag  gacggggtt  22500
ctccatgtg  gtgaggctg  tcttgaact  ccaacctca  gtgatccac  cccctcggc  22560
tcccaaagt  ctggaatta  aggcgtgag  caccgctcc  ggccctgaa  gtactcatt  22620
taaagcact  aggcaacag  tctagttac  tacacggca  ctattatac  ttttcttcc  22680
tattaaaaa  aactatttt  ttcaagatg  ccacttgaa  acactcagc  tccagactc  22740
ctggagttt  tggatagtt  cataatgtg  ttcaggcca  tgtatacat  cgtggaagt  22800
ctgggcaca  acgattcca  gaaagtttg  taagtggag  agactcaac  gggaaggct  22860
tcacctttt  cctgttgct  ttttccttt  ttcccctct  ccttgcctg  aatgctgat  22920
aaacttcca  agattgaga  gttcagccg  catctcaca  atatgcgga  tggagtcac  22980
tgctaagga  gtcagaggg  aaagacaga  ggagtctgg  ctcctgatg  caccatgga  23040
tggccattt  gctctagac  gcccatttc  agatgtcac  ttacataag  attataatt  23100
ctgtggtag  tgggttctt  ttacatgcc  ttaaataca  tcctcgctt  tactgacaa  23160
ttttttttt  tttttgaga  cgagtcttg  tctgtcgcc  aggctggag  gcagtggcg  23220
aatctcggc  cactggaag  tccgcctcc  gggttcacg  cattctcct  cctcagcct  23280
ccgagtagc  gggactaca  gcatgcgcc  ccgtgcccg  ctaattttg  atttttagt  23340
gagacgagg  ttctccatg  ttgtcaggc  ggtctcgaa  tctcaacct  aggtgatca  23400
cctgcctcg  cctcccaca  tgctgggat  acaggcgtg  gccaccacg  ccggcttac  23460
gacaatttt  cctgccaca  tgcccttcc  tagatttcc  aagtaccgt  tttgttctc  23520
tcaataagc  accagcact  ctgaggaac  ggtaggctt  agcaggaca  ttagaagta  23580
gtgggaccc  ggcacacaa  ttttatcag  ggcactttc  tctgatacc  ggaaaagag  23640
tgagtcatt  cacattata  catcactat  ttgtgaatg  gaaaattaa  gttcaaagg  23700
aaaaaataa  cagcttaag  atacagatt  catctccag  ttatctgtc  atccctcac  23760
cctgtctta  cacttccct  aattattct  ctctgttta  tttgcctgg  aaaccccat  23820
tcttctgtt  gtttaaact  cagtttctc  acctcagtg  tattgacat  tggggctgg  23880
caattcttt  tggtgaggg  cagctctgt  ccttatagg  tgtttaaca  tatccctgg  23940
ctctgccca  cagatgcca  tggcacccc  cccctcctc  aagttgtga  aaccaaaat  24000
gtctttgga  attgcagaa  gtcccctgg  ggccaagat  tcccccact  agatcacta  24060
tctcaagtc  ggtcaaaca  cactccaat  tatacctgc  ttgttccca  atgtccccc  24120
caaacttcc  acataacag  tgcagcact  ttacctgtc  gtatctcca  attacactg  24180
atggtcctt  aaggctctt  gactcattt  tgcatctcc  tgtttattg  ctaaatgaa  24240
tttaaaatt  ttcgggaag  caggtgtgg  ggcttgtgc  tgtagtcct  gctacctgg  24300
aggctgagg  aggaggatt  cttgagctt  agcccagga  ttcatggct  cagtgagct  24360
tgatcatgc  actgcactc  agcctgggc  atagagcga  accccatct  taaataaag  24420
aaaataaaa  aaaataaaa  tggcttggg  aaagaatag  aatataatt  aggaattct  24480
ggtccctga  gccatgatt  caacactca  tgtaaagga  tcgtgtcct  tgcctttgc  24540
tggcattgt  ttttataga  tccaatgct  gagtcaaga  gcagattct  gcaaggaag  24600
tatgttgct  attgtttta  acataccaa  taatggaaa  agaggccgg  tgcaggtgg  24660
tcacgccta  aatcccagc  ctttggaaa  ccgaggcgg  catattcca  gagttctgg  24720
ccagcttgg  caacgaagt  ggacgctgt  tctacaaaa  atacaaaaa  tagccggga  24780
tcatggtgc  tgcctgcag  cccagctac  tggaaggct  aggtggaag  atcacttga  24840
cccaggagg  ccaggctgc  gtgaggcat  gtagtggta  tgccactgc  ctccagctt  24900
ggtgacaga  agagaccct  tctcaaaaa  aaaaaaaaa  aaaaagaag  agaaaaagg  24960
aaagaatgc  aagagttta  gaaaacctt  tatattctt  caaagaaaa  tgaaaaact  25020
ttaaatgtt  tgggagaga  tgaagagta  atttctata  aatattttt  tttccttga  25080
ggaatcaaa  ttgagtcaa  ctcgcagaa  atgctgtgt  ccctcttct  agttctaac  25140
tcctcgaat  ttgtcatct  aaattattg  gttacagcc  ggcgcggtg  ctcacacct  25200
taatccctg  attttggga  gccaaagtg  gtggatcac  aggtcagga  ttcgagacc  25260
gcctggcca  tatggtgaa  ccctgtctc  actaaaaat  caaaaatta  ctgggcttg  25320
tggcgagcg  ctgtagtcc  aggtactcg  gaggctgag  cagaagaat  acttgaacc  25380
gggaggcgg  ggttgcaat  agctgagat  gtgccactg  actccagcc  gggcgacag  25440
gcaagactc  atctcaaaa  aaaaaaaat  attgtgtta  atttgtcat  accaagaaa  25500
ggtcttaaa  aaaaaaaga  agaaagaag  aaaaagaaa  caacttgaa  gcataggac  25560
tcattattc  ccagaaatg  atgaagtca  tttggtttg  taggactac  gatcccgta  25620
ttccaattt  attagtata  ttctaaaga  agacatcta  aaaccgttc  aataacgtt  25680
agacgctga  tgtgtgggc  ggaaatcct  ttggttatg  tgacgggtg  ttccttcgg  25740
cctgtggct  cccaccact  tctggaaaa  aagttgcaa  acttcctga  gttcacttg  25800
gtgcacttg  gttctaaga  attcagtac  tctttggca  ctacaaaat  ctgcagttc  25860
tttgcccag  caattaaaa  tgacactaa  agggcatga  aacaaaagg  aaagattca  25920
tcaaaaaat  cgaagatat  gcatggctc  ttttcactt  gcactgacc  ggctctgca  25980
ctggttttg  ttttttttt  taaaagaaa  cacaaactc  ccattgttg  taactattc  26040
ttatgctga  gttcaaagg  agcaagaga  gcaagcttt  tcttgtttg  gagaagctt  26100
gccggatgc  gtgggtcat  cctgtaatc  cagcgcttt  ggaggttga  gtgggcgga  26160
cccttgaac  caggagctc  agaccagcc  gggcaacat  gtgagaccc  atctctaca  26220
aaaatacaa  aaattagcc  gccatggtg  cgtgcactg  tagtcccag  ttctcagga  26280
gctgaggtg  gagaaacac  tgagtccag  aagtcgagg  tgcagtgag  tgtgatcat  26340
ccactgcat  ccaacctgg  caacagagt  agaccctgt  tccagagaa  gaagtttaa  26400
tgttacaag  ccccttcag  attcctata  gaaagaaaa  cagttcatt  gtactgaaa  26460
tttaaactt  ttattttgg  ataatttaa  tgtacagaa  aatttcttt  cttttgaga  26520
gcagtcttg  tctgtcacc  aggctggag  gcagtggca  aatcccagc  cactgcaac  26580
tcctagtag  gatgagggt  caccatgtt  gccaggctg  tcttgaact  ctgacctca  26640
gtgatccac  cgcctcggc  tcccaaagt  ctgggatta  aggcatgag  tcagccaaa  26700
gtacagaaa  gtttcaaag  tagcacaga  aattctcag  cacgccctc  cccggttcc  26760
gtttcccct  atgttaaca  cttacacca  tgtggcaca  ttgtcaaaa  tgagaaacc  26820
acactgaca  attgctagg  actaaactc  agtctttat  tggatttca  cagtttttc  26880
tttaatgac  tttttctgt  ccggggtcc  gcattgatg  taattactt  gcttccgga  26940
agtacacct  cttttgcag  atgtttcat  tttaatttc  gcaaaccgt  tttatctga  27000
gagcttaat  tactcaagt  cagtcttct  agacacaca  cctggggct  tgactgcaa  27060
atggtaaca  ctgatccct  cctccccct  tggtgaggt  gcttaggct  taggtgatg  27120
tgagaattt  tgcatgatc  ggcttgtag  agactgaat  tcctgagaa  gaattaggg  27180
ctctcagca  tttaaaaaa  atcctgttt  tgttttgtt  ttttgtttt  agacaaagt  27240
tcactctat  acccaggca  gagtgcagt  gcgcaatct  agctcacca  aacctctgc  27300
tcctgggtt  aagtgattc  cctgggtca  cctcctgag  agctgagac  acaggcacc  27360
gccaccatg  ccggctaat  ttttttttt  ttttagtat  tttagtaga  acggggttt  27420
gctatgttg  ccaggctga  cttgaactc  tgaccttaa  tgatcagcc  gcctaggcc  27480
ccctaagca  tgggattac  ggcgtgagc  aatgtgcct  gccaaaata  cctcttatt  27540
atagctgac  ttgcacatc  gatattcat  tgggataag  tagcaagct  tactttttc  27600
gttctttct  ttttttttt  ccatgaaaa  aaccaggat  tatgtggtt  caagagcca  27660
ctggataaa  tatagaccc  ttctgtttt  ttgaataaa  gtgatatga  aagaaaaaa  27720
ctccaggaa  agaggaaga  gtataatta  gtttgcctc  gagaaaacc  ggagagaaa  27780
cattcatct  ccattcatt  gtcttccat  cccagacct  ggaagagta  tcactgtaa  27840
atgggggct  gaagcattg  cttatgaaa  agacaggca  aagtaggtt  tcagctcca  27900
cacctagct  ggtaacctt  gacaagttg  ttaacctct  tgagcctca  tttccttgt  27960
tccaaaatg  gggctgagc  ttgaataag  tcctgtatt  aacacagca  atgacatag  28020
gaaaacaca  atttgttac  tattattat  tccaaagac  gtccaccct  attaccaac  28080
ggcattccc  aactcttct  agtctatca  taatctcat  ctttcttct  tctttagat  28140
tttggtagc  aagggctgg  cgcagtggc  cacgcctgt  atcccagca  tttgggagg  28200
tgaggcggg  gaattactt  aggtcagga  ttggagacc  tcctggcca  catggtgaa  28260
ccccgtctc  actaaaaat  caaaaatta  ctgggcatg  tgtcgtgca  ctgtaatcc  28320
agctattcg  gagactgag  taggagaat  atttgaacc  gaggaggca  agtttgcag  28380
gagctgaga  cgcaccact  cattccagc  tgggtaaca  agtgagtga  actctgtct  28440
aaaaaaaaa  aaaaaagga  tttggtagg  aagaagttt  acagttccc  gaggtctac  28500
tgaaacagt  gggtactca  gtcttcaaa  tatgtctaa  tatgtataa  atttgatca  28560
tggtcacaa  cagaaatgg  gtccacaaa  caggaaaaa  gtcacagcg  tgaaccttg  28620
ataagcttt  tccagttgc  ccctcctcc  aactggaaa  aaaatttcc  tctgaccaa  28680
gagtgggct  gacctggtc  caggctgcc  agtatctgc  ctgttagtg  gacctggaa  28740
aaaattccc  gcagaggac  gcaaacatt  gctgagcac  cagacctgt  accctccta  28800
atgaaattc  aggggcagg  tttgaatta  gccataact  gggcttggt  gcttatggg  28860
aagtgctct  tactaaaca  agtgtgtga  gcagtcagg  ctgggaaag  agaggttgg  28920
atctacaat  tgaaaatgt  actctgctg  tttattttt  ttttcagag  cactgtctt  28980
ctctgttgc  tggactgga  tgcaatgct  caatcatag  tcaccataa  ctcaaactc  29040
tgggctcaa  tgatcctcc  accacagcc  tccaagcac  ctgccatgc  cagctaatt  29100
aaaacaatt  ttttttttt  ggtagagat  ggagtcttg  tatgttgcc  aggctggtc  29160
tgatttcct  atccctagt  atcctcctg  ctcagcctc  caaacacac  accacacct  29220
gctaatttt  ttctttttt  ttttgttat  attcagctc  ctttataac  ggcttattt  29280
tattatttt  tgtagagaa  gggtcttgt  atgttatcc  gcctggtct  aaaatgtga  29340
tctgttgtt  tatacaaaa  acaatcatt  tccatttga  aacaagttg  attttccag  29400
ataaaattc  agatttata  actatatta  agtccttag  acccataat  tgtttccaa  29460
aaatacttg  caatgtctg  actttcagt  atctgtaac  tcttggagt  gtggagagt  29520
taagcaact  gtccaagtt  acctagcta  gatgtggtg  agctgaaaa  ctacctttg  29580
ctgtccact  cataagcca  tgcttctag  ccccacatt  cagtgacta  tcttccaag  29640
tctgggaac  gaagatgaa  gaatggaag  tgaatggtt  ctctcccag  tttctctga  29700
gcaaacata  ttatacctc  tcctttgtt  tgggaggtt  ttctcttct  atctcccct  29760
cattcacca  aacagagtt  ggtctatat  ttacccggc  ggctcttgg  actgcataa  29820
tcctggctg  tttcatttt  aaaaaatta  gagattaac  accaaactt  agatgtaag  29880
tgtgggtta  ctctcgatt  tgctagata  cctggaaca  agcattaac  tctttgaga  29940
cttcctttt  tttccttca  tgctgttgt  tgtttctac  agaaaatgt  ggaatgtgc  30000
tgaagacga  ctagcagag  gcctggcac  caggaagga  cttgttgaa  gtatagttc  30060
gggctccaa  acaaaggca  cccatctta  cctgagcca  tctgacttc  ctctaggaa  30120
tactgccta  atatctaaa  gaaagtgat  gcaactgca  ccaactgtt  ctgaggtct  30180
cctgcccac  aatggcccc  tcagcacat  ggaacacgt  tggaggtgc  tggaacaga  30240
actgactca  cggggttct  tacagaggc  gtgcgggtg  agaaatgaa  gcagattcc  30300
caacaatcc  gaggtatat  caagaggag  ggcaggggt  ctttcaagt  accttccag  30360
tgaccaggt  cctttacaa  tctaaggct  tgtgagtat  tttttttct  accttatgg  30420
ataaaggga  aaagaagac  gctgccctg  gtatggctt  gggtcggaa  aaacatttc  30480
caaattgaa  tgtttcagc  atgtcttga  aaatcagat  tgttcagga  tgctggaag  30540
gcattattt  attctaagt  tcacttaaa  gtcttgggg  aggccaggt  ttgtggctc  30600
tgcctgtaa  cccagcact  ttagaggcc  aggcaggcg  atcgcttga  cctaggcat  30660
caagaccag  ctaggcaac  tggtgaaac  ccgtctcta  aaaaaatac  agaatcaac  30720
gggcgtggt  acacatgcc  gtagtccca  ctaccgggg  ggtttgggt  ggaagaggg  30780
ggatgactt  agcccagaa  gctgagact  cagtgagct  agattgtac  actgcactc  30840
agcctgggc  acagagcaa  acactgtct  aaaaaaaca  aacaaaaca  aaagtcttg  30900
ggaaaatca  tgaaaacac  gttatcttt  ttttctttt  tttttcttt  tttcttttt  30960
ttttttttt  agacagagt  ttgttctgt  gctcaggct  gaatgtggt  gcacgatct  31020
agctcactg  aacctccgc  ccccgggtt  aagtgattc  cctgcctca  cctccctag  31080
agctggaat  tcaggtgca  gccaccacg  ctggctaat  tttgtattt  tgtagagat  31140
gggtttcac  aggctgatc  caaactcct  accttaggt  atctgcctg  ctcggcccc  31200
caaagtgct  ggattacag  cgtgagcca  cgcacccag  cgaaaacac  gctttataa  31260
gggattcct  tggcctggt  cagtggctc  cacctgtaa  cccatcacc  tgggaggcc  31320
aggcgagtg  atcacctga  gtcaggagt  tgagaccag  ctggccgac  tagtgaaac  31380
ccgtctcta  taaaaatac  aaaaattag  caggtgtgg  ggcgtgtgc  tgtaatccc  31440
gctactcag  aggctgagg  aggagaatc  cttgaaccc  ggagaggga  gttgcagtg  31500
gctgagatc  tgccactgc  ctccagcct  ggcaacaag  gagaaatct  tctcaaaaa  31560
ataaataaa  actaaaggg  ctcctctaa  cttgaccaa  ggagaaggg  gtgtcccac  31620
ttctctcag  taccagcat  agagggaga  caatttggt  ttgtgcaga  ttaaggttc  31680
cctaaaatt  accatcctt  acctgtgct  tatcatttg  attcaatgc  tttttat  31737



<210> 5070
<211> 260
<212> PRT
<213> Homo sapiens
<308> CAB45016
<400> 5070

Met Val Val Val Ala Ala Ala Pro Asn Pro Ala Asp Gly Thr Pro Lys 
  1               5                  10                  15
Val Leu Leu Leu Ser Gly Gln Pro Ala Ser Ala Ala Gly Ala Pro Ala 
             20                  25                  30
Ala Arg Leu Pro Leu Met Val Pro Ala Gln Arg Gly Ala Ser Pro Glu 
         35                  40                  45
Ala Ala Ser Gly Gly Leu Pro Gln Ala Arg Lys Arg Gln Arg Leu Thr 
     50                  55                  60
His Leu Ser Pro Glu Glu Lys Ala Leu Arg Arg Lys Leu Lys Asn Arg 
 65                  70                  75                  80
Val Ala Ala Gln Thr Ala Arg Asp Arg Lys Lys Ala Arg Met Ser Glu 
                 85                  90                  95
Leu Glu Gln Gln Val Val Asp Leu Glu Glu Glu Asn Gln Lys Leu Leu 
             100                105                110
Leu Glu Asn Gln Leu Leu Arg Glu Lys Thr His Gly Leu Val Val Glu 
         115                120                125
Asn Gln Glu Leu Arg Gln Arg Leu Gly Met Asp Ala Leu Val Ala Glu 
     130                135                140
Glu Glu Ala Glu Ala Lys Gly Asn Glu Val Arg Pro Val Ala Gly Ser 
 145                150                155                160
Ala Glu Ser Ala Ala Leu Arg Leu Arg Ala Pro Leu Gln Gln Val Gln 
                 165                170                175
Ala Gln Leu Ser Pro Leu Gln Asn Ile Ser Pro Trp Ile Leu Ala Val 
             180                185                190
Leu Thr Leu Gln Ile Gln Ser Leu Ile Ser Cys Trp Ala Phe Trp Thr 
         195                200                205
Thr Trp Thr Gln Ser Cys Ser Ser Asn Ala Leu Pro Gln Ser Leu Pro 
     210                215                220
Ala Trp Arg Ser Ser Gln Arg Ser Thr Gln Lys Asp Pro Val Pro Tyr 
 225                230                235                240
Gln Pro Pro Phe Leu Cys Gln Trp Gly Arg His Gln Pro Ser Trp Lys 
                 245                250                255
Pro Leu Met Asn 
             260



<210> 5071
<211> 393
<212> DNA
<213> Rattus norvegicus
<308> AA860049
<400> 5071

ttttttttt  tttttttca  taattcaat  atttattcc  ctaaaaaag  gtgtaaaag  60
atatagctc  catccacaa  gtatatatg  atgacattt  aaatggagg  ctttgtcat  120
gtttctttt  atcaaagtc  ttagtgtat  gaaccagca  tgtgctgta  ttcttaaat  180
aacgtcaaa  agttttgta  tcttcccaa  tgtctgcta  atataaaag  agctcactg  240
aaaatgctt  aaggaaaaa  gaaacaaaa  agaaaatca  aacttccca  aaatgtaca  300
cttttacat  taaaaaagg  tctgagaga  acatacagg  atgccggac  agccctccc  360
tctctcgaa  accatcaat  aagcctcgt  ccg  393



<210> 5072
<211> 308
<212> DNA
<213> Rattus norvegicus
<308> AA866240
<400> 5072

ttttttttt  taaatttaa  gggaacctt  attttaacc  aggaatggg  acacaatga  60
acaagggat  aaaaattgt  atatgaaaa  aataataca  gtggatttg  gcaaaaacc  120
caaaaactg  aagtgcttt  gggatctta  aacaaaatt  aggatgggt  ataaaggga  180
gggactggg  aaaaacctg  aggggattt  aaaagggaa  acatttaaa  ccaaaatgc  240
cgatttatt  aggaaggaa  gaaccaaac  tggaaaatg  gtggcaaaa  ggcaaaacc  300
ttcaaaac  308



<210> 5073
<211> 490
<212> PRT
<213> Rattus norvegicus
<308> AAA41036
<400> 5073

Met Asp Leu Val Thr Phe Leu Val Leu Thr Leu Ser Ser Leu Ile Leu 
  1               5                  10                  15
Leu Ser Leu Trp Arg Gln Ser Ser Arg Arg Arg Lys Leu Pro Pro Gly 
             20                  25                  30
Pro Thr Pro Leu Pro Ile Ile Gly Asn Phe Leu Gln Ile Asp Val Lys 
         35                  40                  45
Asn Ile Ser Gln Ser Leu Thr Lys Phe Ser Lys Thr Tyr Gly Pro Val 
     50                  55                  60
Phe Thr Leu Tyr Leu Gly Ser Gln Pro Thr Val Ile Leu His Gly Tyr 
 65                  70                  75                  80
Glu Ala Ile Lys Glu Ala Leu Ile Asp Asn Gly Glu Lys Phe Ser Gly 
                 85                  90                  95
Arg Gly Ser Tyr Pro Met Asn Glu Asn Val Thr Lys Gly Phe Gly Ile 
             100                105                110
Val Phe Ser Asn Gly Asn Arg Trp Lys Glu Met Arg Arg Phe Thr Ile 
         115                120                125
Met Asn Phe Arg Asn Leu Gly Ile Gly Lys Arg Asn Ile Glu Asp Arg 
     130                135                140
Val Gln Glu Glu Ala Gln Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
 145                150                155                160
Gly Ser Pro Cys Asp Pro Ser Leu Ile Leu Asn Cys Ala Pro Cys Asn 
                 165                170                175
Val Ile Cys Ser Ile Thr Phe Gln Asn His Phe Asp Tyr Lys Asp Lys 
             180                185                190
Glu Met Leu Thr Phe Met Glu Lys Val Asn Glu Asn Leu Lys Ile Met 
         195                200                205
Ser Ser Pro Trp Met Gln Val Cys Asn Ser Phe Pro Ser Leu Ile Asp 
     210                215                220
Tyr Phe Pro Gly Thr His His Lys Ile Ala Lys Asn Ile Asn Tyr Met 
 225                230                235                240
Lys Ser Tyr Leu Leu Lys Lys Ile Glu Glu His Gln Glu Ser Leu Asp 
                 245                250                255
Val Thr Asn Pro Arg Asp Phe Val Asp Tyr Tyr Leu Ile Lys Gln Lys 
             260                265                270
Gln Ala Asn Asn Ile Glu Gln Ser Glu Tyr Ser His Glu Asn Leu Thr 
         275                280                285
Cys Ser Ile Met Asp Leu Ile Gly Ala Gly Thr Glu Thr Met Ser Thr 
     290                295                300
Thr Leu Arg Tyr Ala Leu Leu Leu Leu Met Lys Tyr Pro His Val Thr 
 305                310                315                320
Ala Lys Val Gln Glu Glu Ile Asp Arg Val Ile Gly Arg His Arg Ser 
                 325                330                335
Pro Cys Met Gln Asp Arg Lys His Met Pro Tyr Thr Asp Ala Met Ile 
             340                345                350
His Glu Val Gln Arg Phe Ile Asn Phe Val Pro Thr Asn Leu Pro His 
         355                360                365
Ala Val Thr Cys Asp Ile Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
     370                375                380
Thr Lys Val Leu Thr Ser Leu Thr Ser Val Leu His Asp Ser Lys Glu 
 385                390                395                400
Phe Pro Asn Pro Glu Met Phe Asp Pro Gly His Phe Leu Asp Glu Asn 
                 405                410                415
Gly Asn Phe Lys Lys Ser Asp Tyr Phe Leu Pro Phe Ser Ala Gly Lys 
             420                425                430
Arg Ala Cys Val Gly Glu Gly Leu Ala Arg Met Gln Leu Phe Leu Phe 
         435                440                445
Leu Thr Thr Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Val His Pro 
     450                455                460
Lys Asp Ile Asp Thr Met Pro Val Leu Asn Gly Phe Ala Ser Leu Pro 
 465                470                475                480
Pro Thr Tyr Gln Leu Cys Phe Ile Pro Ser 
                 485                490



<210> 5074
<211> 1473
<212> DNA
<213> Homo sapiens
<308> NM_000769
<400> 5074

atggatcct  ttgtggtcc  tgtgctctg  ctctcatgt  tgcttctcc  ttcaatctg  60
agacagagc  ctgggagag  aaaactccc  cctggcccc  ctcctctcc  agtgattgg  120
aatatccta  agatagata  taaggatgt  agcaaatcc  taaccaatc  ctcaaaaat  180
tatggccct  tgttcactc  gtattttgg  ctggaacgc  tggtggtgc  gcatggata  240
gaagtggtg  aggaagccc  gattgatct  ggagaggag  tttctggaa  aggccattt  300
ccactggct  aaagagcta  cagaggatt  ggaatcgtt  tcagcaatg  aaagagatg  360
aaggagatc  ggcgtttct  cctcatgac  ctgcggaat  ttgggatgg  gaagaggag  420
attgaggac  gtgttcaag  ggaagcccg  tgccttgtg  aggagttga  aaaaaccaa  480
gcttcaccc  gtgatccca  tttcatcct  ggctgtgct  cctgcaatg  gatctgctc  540
attattttc  agaaacgtt  cgattataa  gatcagcaa  ttcttaact  gatggaaaa  600
ttgaatgaa  acatcagga  tgtaagcac  ccctggatc  agatatgca  taattttcc  660
actatcatt  attatttcc  gggaaccca  aacaaatta  ttaaaaacc  tgcttttat  720
gaaagtgat  ttttggaga  agtaaaaga  caccaagaa  cgatggaca  caacaaccc  780
cgggacttt  ttgattgct  cctgatcaa  atggagaag  aaaagcaaa  ccaacagtc  840
gaattcact  ttgaaaact  ggtaatcac  gcagctgac  tacttggag  tgggacaga  900
acaacaagc  caaccctga  atatgctct  cttctcctg  tgaagcacc  agaggtcac  960
gctaaagtc  aggaagaga  tgaacgtgt  attggcaga  accggagcc  ctgcatgca  1020
gacaggggc  acatgccct  cacagatgc  gtggtgcac  aggtccaga  atacatcga  1080
ctcatcccc  ccagcctgc  ccatgcagt  acctgtgac  ttaaattca  aaactacct  1140
attcccaag  gcacaacca  attaacttc  ctcacttct  tgctacatg  caacaaaga  1200
tttcccaac  cagagatgt  tgaccctcg  cactttctg  atgaaggtg  aaattttaa  1260
aaaagtaac  acttcatgc  tttctcagc  ggaaaacgg  tttgtgtgg  agagggcct  1320
gcccgcatg  agctgtttt  attcctgac  ttcatttta  agaacttta  cctgaaatc  1380
ctgattgac  caaaggacc  tgacacaac  cctgttgtc  atggatttg  ttctgtccc  1440
cccttctat  agctgtgct  cattcctgt  tga  1473



<210> 5075
<211> 490
<212> PRT
<213> Homo sapiens
<308> P33261
<400> 5075

Met Asp Pro Phe Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
  1               5                  10                  15
Leu Ser Ile Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
             20                  25                  30
Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Asp Ile Lys 
         35                  40                  45
Asp Val Ser Lys Ser Leu Thr Asn Leu Ser Lys Ile Tyr Gly Pro Val 
     50                  55                  60
Phe Thr Leu Tyr Phe Gly Leu Glu Arg Met Val Val Leu His Gly Tyr 
 65                  70                  75                  80
Glu Val Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                 85                  90                  95
Arg Gly His Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
             100                105                110
Val Phe Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu 
         115                120                125
Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
     130                135                140
Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
 145                150                155                160
Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                 165                170                175
Val Ile Cys Ser Ile Ile Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln 
             180                185                190
Gln Phe Leu Asn Leu Met Glu Lys Leu Asn Glu Asn Ile Arg Ile Val 
         195                200                205
Ser Thr Pro Trp Ile Gln Ile Cys Asn Asn Phe Pro Thr Ile Ile Asp 
     210                215                220
Tyr Phe Pro Gly Thr His Asn Lys Leu Leu Lys Asn Leu Ala Phe Met 
 225                230                235                240
Glu Ser Asp Ile Leu Glu Lys Val Lys Glu His Gln Glu Ser Met Asp 
                 245                250                255
Ile Asn Asn Pro Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
             260                265                270
Lys Glu Lys Gln Asn Gln Gln Ser Glu Phe Thr Ile Glu Asn Leu Val 
         275                280                285
Ile Thr Ala Ala Asp Leu Leu Gly Ala Gly Thr Glu Thr Thr Ser Thr 
     290                295                300
Thr Leu Arg Tyr Ala Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
 305                310                315                320
Ala Lys Val Gln Glu Glu Ile Glu Arg Val Ile Gly Arg Asn Arg Ser 
                 325                330                335
Pro Cys Met Gln Asp Arg Gly His Met Pro Tyr Thr Asp Ala Val Val 
             340                345                350
His Glu Val Gln Arg Tyr Ile Asp Leu Ile Pro Thr Ser Leu Pro His 
         355                360                365
Ala Val Thr Cys Asp Val Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
     370                375                380
Thr Thr Ile Leu Thr Ser Leu Thr Ser Val Leu His Asp Asn Lys Glu 
 385                390                395                400
Phe Pro Asn Pro Glu Met Phe Asp Pro Arg His Phe Leu Asp Glu Gly 
                 405                410                415
Gly Asn Phe Lys Lys Ser Asn Tyr Phe Met Pro Phe Ser Ala Gly Lys 
             420                425                430
Arg Ile Cys Val Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
         435                440                445
Leu Thr Phe Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Ile Asp Pro 
     450                455                460
Lys Asp Leu Asp Thr Thr Pro Val Val Asn Gly Phe Ala Ser Val Pro 
 465                470                475                480
Pro Phe Tyr Gln Leu Cys Phe Ile Pro Val 
                 485                490



<210> 5076
<211> 308
<212> DNA
<213> Rattus norvegicus
<308> AA866240
<400> 5076

ttttttttt  taaatttaa  gggaacctt  attttaacc  aggaatggg  acacaatga  60
acaagggat  aaaaattgt  atatgaaaa  aataataca  gtggatttg  gcaaaaacc  120
caaaaactg  aagtgcttt  gggatctta  aacaaaatt  aggatgggt  ataaaggga  180
gggactggg  aaaaacctg  aggggattt  aaaagggaa  acatttaaa  ccaaaatgc  240
cgatttatt  aggaaggaa  gaaccaaac  tggaaaatg  gtggcaaaa  ggcaaaacc  300
ttcaaaac  308



<210> 5077
<211> 490
<212> PRT
<213> Rattus norvegicus
<308> AAA41036
<400> 5077

Met Asp Leu Val Thr Phe Leu Val Leu Thr Leu Ser Ser Leu Ile Leu 
  1               5                  10                  15
Leu Ser Leu Trp Arg Gln Ser Ser Arg Arg Arg Lys Leu Pro Pro Gly 
             20                  25                  30
Pro Thr Pro Leu Pro Ile Ile Gly Asn Phe Leu Gln Ile Asp Val Lys 
         35                  40                  45
Asn Ile Ser Gln Ser Leu Thr Lys Phe Ser Lys Thr Tyr Gly Pro Val 
     50                  55                  60
Phe Thr Leu Tyr Leu Gly Ser Gln Pro Thr Val Ile Leu His Gly Tyr 
 65                  70                  75                  80
Glu Ala Ile Lys Glu Ala Leu Ile Asp Asn Gly Glu Lys Phe Ser Gly 
                 85                  90                  95
Arg Gly Ser Tyr Pro Met Asn Glu Asn Val Thr Lys Gly Phe Gly Ile 
             100                105                110
Val Phe Ser Asn Gly Asn Arg Trp Lys Glu Met Arg Arg Phe Thr Ile 
         115                120                125
Met Asn Phe Arg Asn Leu Gly Ile Gly Lys Arg Asn Ile Glu Asp Arg 
     130                135                140
Val Gln Glu Glu Ala Gln Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
 145                150                155                160
Gly Ser Pro Cys Asp Pro Ser Leu Ile Leu Asn Cys Ala Pro Cys Asn 
                 165                170                175
Val Ile Cys Ser Ile Thr Phe Gln Asn His Phe Asp Tyr Lys Asp Lys 
             180                185                190
Glu Met Leu Thr Phe Met Glu Lys Val Asn Glu Asn Leu Lys Ile Met 
         195                200                205
Ser Ser Pro Trp Met Gln Val Cys Asn Ser Phe Pro Ser Leu Ile Asp 
     210                215                220
Tyr Phe Pro Gly Thr His His Lys Ile Ala Lys Asn Ile Asn Tyr Met 
 225                230                235                240
Lys Ser Tyr Leu Leu Lys Lys Ile Glu Glu His Gln Glu Ser Leu Asp 
                 245                250                255
Val Thr Asn Pro Arg Asp Phe Val Asp Tyr Tyr Leu Ile Lys Gln Lys 
             260                265                270
Gln Ala Asn Asn Ile Glu Gln Ser Glu Tyr Ser His Glu Asn Leu Thr 
         275                280                285
Cys Ser Ile Met Asp Leu Ile Gly Ala Gly Thr Glu Thr Met Ser Thr 
     290                295                300
Thr Leu Arg Tyr Ala Leu Leu Leu Leu Met Lys Tyr Pro His Val Thr 
 305                310                315                320
Ala Lys Val Gln Glu Glu Ile Asp Arg Val Ile Gly Arg His Arg Ser 
                 325                330                335
Pro Cys Met Gln Asp Arg Lys His Met Pro Tyr Thr Asp Ala Met Ile 
             340                345                350
His Glu Val Gln Arg Phe Ile Asn Phe Val Pro Thr Asn Leu Pro His 
         355                360                365
Ala Val Thr Cys Asp Ile Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
     370                375                380
Thr Lys Val Leu Thr Ser Leu Thr Ser Val Leu His Asp Ser Lys Glu 
 385                390                395                400
Phe Pro Asn Pro Glu Met Phe Asp Pro Gly His Phe Leu Asp Glu Asn 
                 405                410                415
Gly Asn Phe Lys Lys Ser Asp Tyr Phe Leu Pro Phe Ser Ala Gly Lys 
             420                425                430
Arg Ala Cys Val Gly Glu Gly Leu Ala Arg Met Gln Leu Phe Leu Phe 
         435                440                445
Leu Thr Thr Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Val His Pro 
     450                455                460
Lys Asp Ile Asp Thr Met Pro Val Leu Asn Gly Phe Ala Ser Leu Pro 
 465                470                475                480
Pro Thr Tyr Gln Leu Cys Phe Ile Pro Ser 
                 485                490



<210> 5078
<211> 1473
<212> DNA
<213> Homo sapiens
<308> NM_000769
<400> 5078

atggatcct  ttgtggtcc  tgtgctctg  ctctcatgt  tgcttctcc  ttcaatctg  60
agacagagc  ctgggagag  aaaactccc  cctggcccc  ctcctctcc  agtgattgg  120
aatatccta  agatagata  taaggatgt  agcaaatcc  taaccaatc  ctcaaaaat  180
tatggccct  tgttcactc  gtattttgg  ctggaacgc  tggtggtgc  gcatggata  240
gaagtggtg  aggaagccc  gattgatct  ggagaggag  tttctggaa  aggccattt  300
ccactggct  aaagagcta  cagaggatt  ggaatcgtt  tcagcaatg  aaagagatg  360
aaggagatc  ggcgtttct  cctcatgac  ctgcggaat  ttgggatgg  gaagaggag  420
attgaggac  gtgttcaag  ggaagcccg  tgccttgtg  aggagttga  aaaaaccaa  480
gcttcaccc  gtgatccca  tttcatcct  ggctgtgct  cctgcaatg  gatctgctc  540
attattttc  agaaacgtt  cgattataa  gatcagcaa  ttcttaact  gatggaaaa  600
ttgaatgaa  acatcagga  tgtaagcac  ccctggatc  agatatgca  taattttcc  660
actatcatt  attatttcc  gggaaccca  aacaaatta  ttaaaaacc  tgcttttat  720
gaaagtgat  ttttggaga  agtaaaaga  caccaagaa  cgatggaca  caacaaccc  780
cgggacttt  ttgattgct  cctgatcaa  atggagaag  aaaagcaaa  ccaacagtc  840
gaattcact  ttgaaaact  ggtaatcac  gcagctgac  tacttggag  tgggacaga  900
acaacaagc  caaccctga  atatgctct  cttctcctg  tgaagcacc  agaggtcac  960
gctaaagtc  aggaagaga  tgaacgtgt  attggcaga  accggagcc  ctgcatgca  1020
gacaggggc  acatgccct  cacagatgc  gtggtgcac  aggtccaga  atacatcga  1080
ctcatcccc  ccagcctgc  ccatgcagt  acctgtgac  ttaaattca  aaactacct  1140
attcccaag  gcacaacca  attaacttc  ctcacttct  tgctacatg  caacaaaga  1200
tttcccaac  cagagatgt  tgaccctcg  cactttctg  atgaaggtg  aaattttaa  1260
aaaagtaac  acttcatgc  tttctcagc  ggaaaacgg  tttgtgtgg  agagggcct  1320
gcccgcatg  agctgtttt  attcctgac  ttcatttta  agaacttta  cctgaaatc  1380
ctgattgac  caaaggacc  tgacacaac  cctgttgtc  atggatttg  ttctgtccc  1440
cccttctat  agctgtgct  cattcctgt  tga  1473



<210> 5079
<211> 490
<212> PRT
<213> Homo sapiens
<308> P33261
<400> 5079

Met Asp Pro Phe Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
  1               5                  10                  15
Leu Ser Ile Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
             20                  25                  30
Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Asp Ile Lys 
         35                  40                  45
Asp Val Ser Lys Ser Leu Thr Asn Leu Ser Lys Ile Tyr Gly Pro Val 
     50                  55                  60
Phe Thr Leu Tyr Phe Gly Leu Glu Arg Met Val Val Leu His Gly Tyr 
 65                  70                  75                  80
Glu Val Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                 85                  90                  95
Arg Gly His Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
             100                105                110
Val Phe Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu 
         115                120                125
Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
     130                135                140
Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
 145                150                155                160
Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                 165                170                175
Val Ile Cys Ser Ile Ile Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln 
             180                185                190
Gln Phe Leu Asn Leu Met Glu Lys Leu Asn Glu Asn Ile Arg Ile Val 
         195                200                205
Ser Thr Pro Trp Ile Gln Ile Cys Asn Asn Phe Pro Thr Ile Ile Asp 
     210                215                220
Tyr Phe Pro Gly Thr His Asn Lys Leu Leu Lys Asn Leu Ala Phe Met 
 225                230                235                240
Glu Ser Asp Ile Leu Glu Lys Val Lys Glu His Gln Glu Ser Met Asp 
                 245                250                255
Ile Asn Asn Pro Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
             260                265                270
Lys Glu Lys Gln Asn Gln Gln Ser Glu Phe Thr Ile Glu Asn Leu Val 
         275                280                285
Ile Thr Ala Ala Asp Leu Leu Gly Ala Gly Thr Glu Thr Thr Ser Thr 
     290                295                300
Thr Leu Arg Tyr Ala Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
 305                310                315                320
Ala Lys Val Gln Glu Glu Ile Glu Arg Val Ile Gly Arg Asn Arg Ser 
                 325                330                335
Pro Cys Met Gln Asp Arg Gly His Met Pro Tyr Thr Asp Ala Val Val 
             340                345                350
His Glu Val Gln Arg Tyr Ile Asp Leu Ile Pro Thr Ser Leu Pro His 
         355                360                365
Ala Val Thr Cys Asp Val Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
     370                375                380
Thr Thr Ile Leu Thr Ser Leu Thr Ser Val Leu His Asp Asn Lys Glu 
 385                390                395                400
Phe Pro Asn Pro Glu Met Phe Asp Pro Arg His Phe Leu Asp Glu Gly 
                 405                410                415
Gly Asn Phe Lys Lys Ser Asn Tyr Phe Met Pro Phe Ser Ala Gly Lys 
             420                425                430
Arg Ile Cys Val Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
         435                440                445
Leu Thr Phe Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Ile Asp Pro 
     450                455                460
Lys Asp Leu Asp Thr Thr Pro Val Val Asn Gly Phe Ala Ser Val Pro 
 465                470                475                480
Pro Phe Tyr Gln Leu Cys Phe Ile Pro Val 
                 485                490



<210> 5080
<211> 308
<212> DNA
<213> Rattus norvegicus
<308> AA866240
<400> 5080

ttttttttt  taaatttaa  gggaacctt  attttaacc  aggaatggg  acacaatga  60
acaagggat  aaaaattgt  atatgaaaa  aataataca  gtggatttg  gcaaaaacc  120
caaaaactg  aagtgcttt  gggatctta  aacaaaatt  aggatgggt  ataaaggga  180
gggactggg  aaaaacctg  aggggattt  aaaagggaa  acatttaaa  ccaaaatgc  240
cgatttatt  aggaaggaa  gaaccaaac  tggaaaatg  gtggcaaaa  ggcaaaacc  300
ttcaaaac  308



<210> 5081
<211> 490
<212> PRT
<213> Rattus norvegicus
<308> AAA41036
<400> 5081

Met Asp Leu Val Thr Phe Leu Val Leu Thr Leu Ser Ser Leu Ile Leu 
  1               5                  10                  15
Leu Ser Leu Trp Arg Gln Ser Ser Arg Arg Arg Lys Leu Pro Pro Gly 
             20                  25                  30
Pro Thr Pro Leu Pro Ile Ile Gly Asn Phe Leu Gln Ile Asp Val Lys 
         35                  40                  45
Asn Ile Ser Gln Ser Leu Thr Lys Phe Ser Lys Thr Tyr Gly Pro Val 
     50                  55                  60
Phe Thr Leu Tyr Leu Gly Ser Gln Pro Thr Val Ile Leu His Gly Tyr 
 65                  70                  75                  80
Glu Ala Ile Lys Glu Ala Leu Ile Asp Asn Gly Glu Lys Phe Ser Gly 
                 85                  90                  95
Arg Gly Ser Tyr Pro Met Asn Glu Asn Val Thr Lys Gly Phe Gly Ile 
             100                105                110
Val Phe Ser Asn Gly Asn Arg Trp Lys Glu Met Arg Arg Phe Thr Ile 
         115                120                125
Met Asn Phe Arg Asn Leu Gly Ile Gly Lys Arg Asn Ile Glu Asp Arg 
     130                135                140
Val Gln Glu Glu Ala Gln Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
 145                150                155                160
Gly Ser Pro Cys Asp Pro Ser Leu Ile Leu Asn Cys Ala Pro Cys Asn 
                 165                170                175
Val Ile Cys Ser Ile Thr Phe Gln Asn His Phe Asp Tyr Lys Asp Lys 
             180                185                190
Glu Met Leu Thr Phe Met Glu Lys Val Asn Glu Asn Leu Lys Ile Met 
         195                200                205
Ser Ser Pro Trp Met Gln Val Cys Asn Ser Phe Pro Ser Leu Ile Asp 
     210                215                220
Tyr Phe Pro Gly Thr His His Lys Ile Ala Lys Asn Ile Asn Tyr Met 
 225                230                235                240
Lys Ser Tyr Leu Leu Lys Lys Ile Glu Glu His Gln Glu Ser Leu Asp 
                 245                250                255
Val Thr Asn Pro Arg Asp Phe Val Asp Tyr Tyr Leu Ile Lys Gln Lys 
             260                265                270
Gln Ala Asn Asn Ile Glu Gln Ser Glu Tyr Ser His Glu Asn Leu Thr 
         275                280                285
Cys Ser Ile Met Asp Leu Ile Gly Ala Gly Thr Glu Thr Met Ser Thr 
     290                295                300
Thr Leu Arg Tyr Ala Leu Leu Leu Leu Met Lys Tyr Pro His Val Thr 
 305                310                315                320
Ala Lys Val Gln Glu Glu Ile Asp Arg Val Ile Gly Arg His Arg Ser 
                 325                330                335
Pro Cys Met Gln Asp Arg Lys His Met Pro Tyr Thr Asp Ala Met Ile 
             340                345                350
His Glu Val Gln Arg Phe Ile Asn Phe Val Pro Thr Asn Leu Pro His 
         355                360                365
Ala Val Thr Cys Asp Ile Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
     370                375                380
Thr Lys Val Leu Thr Ser Leu Thr Ser Val Leu His Asp Ser Lys Glu 
 385                390                395                400
Phe Pro Asn Pro Glu Met Phe Asp Pro Gly His Phe Leu Asp Glu Asn 
                 405                410                415
Gly Asn Phe Lys Lys Ser Asp Tyr Phe Leu Pro Phe Ser Ala Gly Lys 
             420                425                430
Arg Ala Cys Val Gly Glu Gly Leu Ala Arg Met Gln Leu Phe Leu Phe 
         435                440                445
Leu Thr Thr Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Val His Pro 
     450                455                460
Lys Asp Ile Asp Thr Met Pro Val Leu Asn Gly Phe Ala Ser Leu Pro 
 465                470                475                480
Pro Thr Tyr Gln Leu Cys Phe Ile Pro Ser 
                 485                490



<210> 5082
<211> 1473
<212> DNA
<213> Homo sapiens
<308> NM_000769
<400> 5082

atggatcct  ttgtggtcc  tgtgctctg  ctctcatgt  tgcttctcc  ttcaatctg  60
agacagagc  ctgggagag  aaaactccc  cctggcccc  ctcctctcc  agtgattgg  120
aatatccta  agatagata  taaggatgt  agcaaatcc  taaccaatc  ctcaaaaat  180
tatggccct  tgttcactc  gtattttgg  ctggaacgc  tggtggtgc  gcatggata  240
gaagtggtg  aggaagccc  gattgatct  ggagaggag  tttctggaa  aggccattt  300
ccactggct  aaagagcta  cagaggatt  ggaatcgtt  tcagcaatg  aaagagatg  360
aaggagatc  ggcgtttct  cctcatgac  ctgcggaat  ttgggatgg  gaagaggag  420
attgaggac  gtgttcaag  ggaagcccg  tgccttgtg  aggagttga  aaaaaccaa  480
gcttcaccc  gtgatccca  tttcatcct  ggctgtgct  cctgcaatg  gatctgctc  540
attattttc  agaaacgtt  cgattataa  gatcagcaa  ttcttaact  gatggaaaa  600
ttgaatgaa  acatcagga  tgtaagcac  ccctggatc  agatatgca  taattttcc  660
actatcatt  attatttcc  gggaaccca  aacaaatta  ttaaaaacc  tgcttttat  720
gaaagtgat  ttttggaga  agtaaaaga  caccaagaa  cgatggaca  caacaaccc  780
cgggacttt  ttgattgct  cctgatcaa  atggagaag  aaaagcaaa  ccaacagtc  840
gaattcact  ttgaaaact  ggtaatcac  gcagctgac  tacttggag  tgggacaga  900
acaacaagc  caaccctga  atatgctct  cttctcctg  tgaagcacc  agaggtcac  960
gctaaagtc  aggaagaga  tgaacgtgt  attggcaga  accggagcc  ctgcatgca  1020
gacaggggc  acatgccct  cacagatgc  gtggtgcac  aggtccaga  atacatcga  1080
ctcatcccc  ccagcctgc  ccatgcagt  acctgtgac  ttaaattca  aaactacct  1140
attcccaag  gcacaacca  attaacttc  ctcacttct  tgctacatg  caacaaaga  1200
tttcccaac  cagagatgt  tgaccctcg  cactttctg  atgaaggtg  aaattttaa  1260
aaaagtaac  acttcatgc  tttctcagc  ggaaaacgg  tttgtgtgg  agagggcct  1320
gcccgcatg  agctgtttt  attcctgac  ttcatttta  agaacttta  cctgaaatc  1380
ctgattgac  caaaggacc  tgacacaac  cctgttgtc  atggatttg  ttctgtccc  1440
cccttctat  agctgtgct  cattcctgt  tga  1473



<210> 5083
<211> 490
<212> PRT
<213> Homo sapiens
<308> P33261
<400> 5083

Met Asp Pro Phe Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
  1               5                  10                  15
Leu Ser Ile Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
             20                  25                  30
Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Asp Ile Lys 
         35                  40                  45
Asp Val Ser Lys Ser Leu Thr Asn Leu Ser Lys Ile Tyr Gly Pro Val 
     50                  55                  60
Phe Thr Leu Tyr Phe Gly Leu Glu Arg Met Val Val Leu His Gly Tyr 
 65                  70                  75                  80
Glu Val Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                 85                  90                  95
Arg Gly His Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
             100                105                110
Val Phe Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu 
         115                120                125
Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
     130                135                140
Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
 145                150                155                160
Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                 165                170                175
Val Ile Cys Ser Ile Ile Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln 
             180                185                190
Gln Phe Leu Asn Leu Met Glu Lys Leu Asn Glu Asn Ile Arg Ile Val 
         195                200                205
Ser Thr Pro Trp Ile Gln Ile Cys Asn Asn Phe Pro Thr Ile Ile Asp 
     210                215                220
Tyr Phe Pro Gly Thr His Asn Lys Leu Leu Lys Asn Leu Ala Phe Met 
 225                230                235                240
Glu Ser Asp Ile Leu Glu Lys Val Lys Glu His Gln Glu Ser Met Asp 
                 245                250                255
Ile Asn Asn Pro Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
             260                265                270
Lys Glu Lys Gln Asn Gln Gln Ser Glu Phe Thr Ile Glu Asn Leu Val 
         275                280                285
Ile Thr Ala Ala Asp Leu Leu Gly Ala Gly Thr Glu Thr Thr Ser Thr 
     290                295                300
Thr Leu Arg Tyr Ala Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
 305                310                315                320
Ala Lys Val Gln Glu Glu Ile Glu Arg Val Ile Gly Arg Asn Arg Ser 
                 325                330                335
Pro Cys Met Gln Asp Arg Gly His Met Pro Tyr Thr Asp Ala Val Val 
             340                345                350
His Glu Val Gln Arg Tyr Ile Asp Leu Ile Pro Thr Ser Leu Pro His 
         355                360                365
Ala Val Thr Cys Asp Val Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
     370                375                380
Thr Thr Ile Leu Thr Ser Leu Thr Ser Val Leu His Asp Asn Lys Glu 
 385                390                395                400
Phe Pro Asn Pro Glu Met Phe Asp Pro Arg His Phe Leu Asp Glu Gly 
                 405                410                415
Gly Asn Phe Lys Lys Ser Asn Tyr Phe Met Pro Phe Ser Ala Gly Lys 
             420                425                430
Arg Ile Cys Val Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
         435                440                445
Leu Thr Phe Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Ile Asp Pro 
     450                455                460
Lys Asp Leu Asp Thr Thr Pro Val Val Asn Gly Phe Ala Ser Val Pro 
 465                470                475                480
Pro Phe Tyr Gln Leu Cys Phe Ile Pro Val 
                 485                490



<210> 5084
<211> 308
<212> DNA
<213> Rattus norvegicus
<308> AA866240
<400> 5084

ttttttttt  taaatttaa  gggaacctt  attttaacc  aggaatggg  acacaatga  60
acaagggat  aaaaattgt  atatgaaaa  aataataca  gtggatttg  gcaaaaacc  120
caaaaactg  aagtgcttt  gggatctta  aacaaaatt  aggatgggt  ataaaggga  180
gggactggg  aaaaacctg  aggggattt  aaaagggaa  acatttaaa  ccaaaatgc  240
cgatttatt  aggaaggaa  gaaccaaac  tggaaaatg  gtggcaaaa  ggcaaaacc  300
ttcaaaac  308



<210> 5085
<211> 490
<212> PRT
<213> Rattus norvegicus
<308> AAA41036
<400> 5085

Met Asp Leu Val Thr Phe Leu Val Leu Thr Leu Ser Ser Leu Ile Leu 
  1               5                  10                  15
Leu Ser Leu Trp Arg Gln Ser Ser Arg Arg Arg Lys Leu Pro Pro Gly 
             20                  25                  30
Pro Thr Pro Leu Pro Ile Ile Gly Asn Phe Leu Gln Ile Asp Val Lys 
         35                  40                  45
Asn Ile Ser Gln Ser Leu Thr Lys Phe Ser Lys Thr Tyr Gly Pro Val 
     50                  55                  60
Phe Thr Leu Tyr Leu Gly Ser Gln Pro Thr Val Ile Leu His Gly Tyr 
 65                  70                  75                  80
Glu Ala Ile Lys Glu Ala Leu Ile Asp Asn Gly Glu Lys Phe Ser Gly 
                 85                  90                  95
Arg Gly Ser Tyr Pro Met Asn Glu Asn Val Thr Lys Gly Phe Gly Ile 
             100                105                110
Val Phe Ser Asn Gly Asn Arg Trp Lys Glu Met Arg Arg Phe Thr Ile 
         115                120                125
Met Asn Phe Arg Asn Leu Gly Ile Gly Lys Arg Asn Ile Glu Asp Arg 
     130                135                140
Val Gln Glu Glu Ala Gln Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
 145                150                155                160
Gly Ser Pro Cys Asp Pro Ser Leu Ile Leu Asn Cys Ala Pro Cys Asn 
                 165                170                175
Val Ile Cys Ser Ile Thr Phe Gln Asn His Phe Asp Tyr Lys Asp Lys 
             180                185                190
Glu Met Leu Thr Phe Met Glu Lys Val Asn Glu Asn Leu Lys Ile Met 
         195                200                205
Ser Ser Pro Trp Met Gln Val Cys Asn Ser Phe Pro Ser Leu Ile Asp 
     210                215                220
Tyr Phe Pro Gly Thr His His Lys Ile Ala Lys Asn Ile Asn Tyr Met 
 225                230                235                240
Lys Ser Tyr Leu Leu Lys Lys Ile Glu Glu His Gln Glu Ser Leu Asp 
                 245                250                255
Val Thr Asn Pro Arg Asp Phe Val Asp Tyr Tyr Leu Ile Lys Gln Lys 
             260                265                270
Gln Ala Asn Asn Ile Glu Gln Ser Glu Tyr Ser His Glu Asn Leu Thr 
         275                280                285
Cys Ser Ile Met Asp Leu Ile Gly Ala Gly Thr Glu Thr Met Ser Thr 
     290                295                300
Thr Leu Arg Tyr Ala Leu Leu Leu Leu Met Lys Tyr Pro His Val Thr 
 305                310                315                320
Ala Lys Val Gln Glu Glu Ile Asp Arg Val Ile Gly Arg His Arg Ser 
                 325                330                335
Pro Cys Met Gln Asp Arg Lys His Met Pro Tyr Thr Asp Ala Met Ile 
             340                345                350
His Glu Val Gln Arg Phe Ile Asn Phe Val Pro Thr Asn Leu Pro His 
         355                360                365
Ala Val Thr Cys Asp Ile Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
     370                375                380
Thr Lys Val Leu Thr Ser Leu Thr Ser Val Leu His Asp Ser Lys Glu 
 385                390                395                400
Phe Pro Asn Pro Glu Met Phe Asp Pro Gly His Phe Leu Asp Glu Asn 
                 405                410                415
Gly Asn Phe Lys Lys Ser Asp Tyr Phe Leu Pro Phe Ser Ala Gly Lys 
             420                425                430
Arg Ala Cys Val Gly Glu Gly Leu Ala Arg Met Gln Leu Phe Leu Phe 
         435                440                445
Leu Thr Thr Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Val His Pro 
     450                455                460
Lys Asp Ile Asp Thr Met Pro Val Leu Asn Gly Phe Ala Ser Leu Pro 
 465                470                475                480
Pro Thr Tyr Gln Leu Cys Phe Ile Pro Ser 
                 485                490



<210> 5086
<211> 1473
<212> DNA
<213> Homo sapiens
<308> NM_000769
<400> 5086

atggatcct  ttgtggtcc  tgtgctctg  ctctcatgt  tgcttctcc  ttcaatctg  60
agacagagc  ctgggagag  aaaactccc  cctggcccc  ctcctctcc  agtgattgg  120
aatatccta  agatagata  taaggatgt  agcaaatcc  taaccaatc  ctcaaaaat  180
tatggccct  tgttcactc  gtattttgg  ctggaacgc  tggtggtgc  gcatggata  240
gaagtggtg  aggaagccc  gattgatct  ggagaggag  tttctggaa  aggccattt  300
ccactggct  aaagagcta  cagaggatt  ggaatcgtt  tcagcaatg  aaagagatg  360
aaggagatc  ggcgtttct  cctcatgac  ctgcggaat  ttgggatgg  gaagaggag  420
attgaggac  gtgttcaag  ggaagcccg  tgccttgtg  aggagttga  aaaaaccaa  480
gcttcaccc  gtgatccca  tttcatcct  ggctgtgct  cctgcaatg  gatctgctc  540
attattttc  agaaacgtt  cgattataa  gatcagcaa  ttcttaact  gatggaaaa  600
ttgaatgaa  acatcagga  tgtaagcac  ccctggatc  agatatgca  taattttcc  660
actatcatt  attatttcc  gggaaccca  aacaaatta  ttaaaaacc  tgcttttat  720
gaaagtgat  ttttggaga  agtaaaaga  caccaagaa  cgatggaca  caacaaccc  780
cgggacttt  ttgattgct  cctgatcaa  atggagaag  aaaagcaaa  ccaacagtc  840
gaattcact  ttgaaaact  ggtaatcac  gcagctgac  tacttggag  tgggacaga  900
acaacaagc  caaccctga  atatgctct  cttctcctg  tgaagcacc  agaggtcac  960
gctaaagtc  aggaagaga  tgaacgtgt  attggcaga  accggagcc  ctgcatgca  1020
gacaggggc  acatgccct  cacagatgc  gtggtgcac  aggtccaga  atacatcga  1080
ctcatcccc  ccagcctgc  ccatgcagt  acctgtgac  ttaaattca  aaactacct  1140
attcccaag  gcacaacca  attaacttc  ctcacttct  tgctacatg  caacaaaga  1200
tttcccaac  cagagatgt  tgaccctcg  cactttctg  atgaaggtg  aaattttaa  1260
aaaagtaac  acttcatgc  tttctcagc  ggaaaacgg  tttgtgtgg  agagggcct  1320
gcccgcatg  agctgtttt  attcctgac  ttcatttta  agaacttta  cctgaaatc  1380
ctgattgac  caaaggacc  tgacacaac  cctgttgtc  atggatttg  ttctgtccc  1440
cccttctat  agctgtgct  cattcctgt  tga  1473



<210> 5087
<211> 490
<212> PRT
<213> Homo sapiens
<308> P33261
<400> 5087

Met Asp Pro Phe Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
  1               5                  10                  15
Leu Ser Ile Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
             20                  25                  30
Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Asp Ile Lys 
         35                  40                  45
Asp Val Ser Lys Ser Leu Thr Asn Leu Ser Lys Ile Tyr Gly Pro Val 
     50                  55                  60
Phe Thr Leu Tyr Phe Gly Leu Glu Arg Met Val Val Leu His Gly Tyr 
 65                  70                  75                  80
Glu Val Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                 85                  90                  95
Arg Gly His Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
             100                105                110
Val Phe Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu 
         115                120                125
Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
     130                135                140
Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
 145                150                155                160
Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                 165                170                175
Val Ile Cys Ser Ile Ile Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln 
             180                185                190
Gln Phe Leu Asn Leu Met Glu Lys Leu Asn Glu Asn Ile Arg Ile Val 
         195                200                205
Ser Thr Pro Trp Ile Gln Ile Cys Asn Asn Phe Pro Thr Ile Ile Asp 
     210                215                220
Tyr Phe Pro Gly Thr His Asn Lys Leu Leu Lys Asn Leu Ala Phe Met 
 225                230                235                240
Glu Ser Asp Ile Leu Glu Lys Val Lys Glu His Gln Glu Ser Met Asp 
                 245                250                255
Ile Asn Asn Pro Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
             260                265                270
Lys Glu Lys Gln Asn Gln Gln Ser Glu Phe Thr Ile Glu Asn Leu Val 
         275                280                285
Ile Thr Ala Ala Asp Leu Leu Gly Ala Gly Thr Glu Thr Thr Ser Thr 
     290                295                300
Thr Leu Arg Tyr Ala Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
 305                310                315                320
Ala Lys Val Gln Glu Glu Ile Glu Arg Val Ile Gly Arg Asn Arg Ser 
                 325                330                335
Pro Cys Met Gln Asp Arg Gly His Met Pro Tyr Thr Asp Ala Val Val 
             340                345                350
His Glu Val Gln Arg Tyr Ile Asp Leu Ile Pro Thr Ser Leu Pro His 
         355                360                365
Ala Val Thr Cys Asp Val Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
     370                375                380
Thr Thr Ile Leu Thr Ser Leu Thr Ser Val Leu His Asp Asn Lys Glu 
 385                390                395                400
Phe Pro Asn Pro Glu Met Phe Asp Pro Arg His Phe Leu Asp Glu Gly 
                 405                410                415
Gly Asn Phe Lys Lys Ser Asn Tyr Phe Met Pro Phe Ser Ala Gly Lys 
             420                425                430
Arg Ile Cys Val Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
         435                440                445
Leu Thr Phe Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Ile Asp Pro 
     450                455                460
Lys Asp Leu Asp Thr Thr Pro Val Val Asn Gly Phe Ala Ser Val Pro 
 465                470                475                480
Pro Phe Tyr Gln Leu Cys Phe Ile Pro Val 
                 485                490



<210> 5088
<211> 437
<212> DNA
<213> Rattus norvegicus
<308> AA866257
<400> 5088

ttttttttt  ttttgttgt  gatctattt  tgctacaca  cgtttattg  acaccgttt  60
ataaaaata  agtaaatta  aatgtgctg  ggaaggttg  agcttgctg  tgggaagct  120
atgccagaa  aggccgtga  cttggggat  tgggctctt  aaaggcaga  agattatgg  180
tgggggttt  ggggctggg  tgcagacaa  ccagagcca  ttcctgtac  ccctcacat  240
aggtgctct  tggaaggag  gccaaaccc  gggcaccag  gtcaagagg  aagcagcca  300
ctgtctgaa  acggtgatt  tgagacatg  atagttaga  atggtcacc  actgacaag  360
caccaaagg  tcctattct  gacctcnct  gggtatgct  tagattgac  ccctgngtg  420
atctgacta  aaatcaa  437



<210> 5089
<211> 127
<212> PRT
<213> Rattus norvegicus
<308> AAH05733
<400> 5089

Met Pro Leu Phe Gly Ser Ile Phe Ser Pro Lys Lys Thr Pro Pro Arg 
  1               5                  10                  15
Lys Ser Ala Ser Leu Ser Asn Leu His Ser Leu Asp Arg Ser Thr Arg 
             20                  25                  30
Glu Leu Glu Leu Gly Leu Asp Tyr Gly Thr Pro Thr Met Asn Leu Ala 
         35                  40                  45
Gly Gln Ser Leu Lys Phe Glu Asn Gly Gln Trp Val Ala Asp Ser Val 
     50                  55                  60
Ile Ser Gly Gly Val Asp Arg Arg Glu Thr Gln Arg Leu Arg Lys Arg 
 65                  70                  75                  80
Asn Gln Gln Leu Glu Glu Glu Asn Asn Leu Leu Arg Leu Lys Val Asp 
                 85                  90                  95
Ile Leu Leu Asp Met Leu Ser Glu Thr Thr Ala Glu Ser His Leu Lys 
             100                105                110
Asp Lys Glu Leu Asp Glu Leu Lys Val Thr Asn Arg Arg Arg Lys 
         115                120                125



<210> 5090
<211> 493
<212> DNA
<213> Rattus norvegicus
<308> AA866276
<400> 5090

ttttttttt  tttttttca  ctttatatt  agatttttt  tcttaaaaa  aagaacatt  60
tagatgtga  gggtgggaa  ggatgactg  cagcaggtg  tatagaaac  caaagctcc  120
gaaaattaa  aaaaaataa  atatatatt  atacattta  atatatata  ataccaagt  180
atgcatgtg  gtcccagag  agcagaaag  agcagcaag  agcaactag  acacaagga  240
ctgggttca  gtacagcac  cacaagcca  tccaatcct  ataacccac  ccaagccca  300
cccccaccc  caagaaaag  tgtttaaga  acttccctc  taaatgggg  tgcacaact  360
gggtactgt  gcacatctg  aatctcagc  cctggacgg  ggagacgtt  agataaggg  420
tcaatggaa  ccttagcga  acaattaag  ttgagacca  cttgggcta  attaagaac  480
tctccaaag  tat  493



<210> 5091
<211> 296
<212> PRT
<213> Rattus norvegicus
<308> NP_058665
<400> 5091

Met Pro Val Thr Val Thr Arg Thr Thr Ile Thr Thr Thr Thr Ser Ser 
  1               5                  10                  15
Ser Thr Thr Val Gly Ser Ala Arg Ala Leu Thr Gln Pro Leu Gly Leu 
             20                  25                  30
Leu Arg Leu Leu Gln Leu Ile Ser Thr Cys Val Ala Phe Ser Leu Val 
         35                  40                  45
Ala Ser Val Gly Ala Trp Thr Gly Pro Met Gly Asn Trp Ala Met Phe 
     50                  55                  60
Thr Trp Cys Phe Cys Phe Ala Val Thr Leu Ile Ile Leu Ile Val Glu 
 65                  70                  75                  80
Leu Gly Gly Leu Gln Ala His Phe Pro Leu Ser Trp Arg Asn Phe Pro 
                 85                  90                  95
Ile Thr Phe Ala Cys Tyr Ala Ala Leu Phe Cys Leu Ser Ser Ser Ile 
             100                105                110
Ile Tyr Pro Thr Thr Tyr Val Gln Phe Leu Ala His Gly Arg Thr Arg 
         115                120                125
Asp His Ala Ile Ala Ala Thr Thr Phe Ser Cys Val Ala Cys Leu Ala 
     130                135                140
Tyr Ala Thr Glu Val Ala Trp Thr Arg Ala Arg Pro Gly Glu Ile Thr 
 145                150                155                160
Gly Tyr Met Ala Thr Val Pro Gly Leu Leu Lys Val Phe Glu Thr Phe 
                 165                170                175
Val Ala Cys Ile Ile Phe Ala Phe Ile Gly Glu Pro Leu Leu Tyr Asn 
             180                185                190
Gln Lys Pro Ala Leu Glu Trp Cys Val Ala Val Tyr Ala Ile Cys Phe 
         195                200                205
Ile Leu Ala Gly Val Thr Ile Leu Leu Asn Leu Gly Asp Cys Thr Asn 
     210                215                220
Val Leu Pro Ile Pro Phe Pro Thr Phe Leu Ser Gly Leu Ala Tyr Ser 
 225                230                235                240
Leu Phe Ser Phe Thr Pro Leu Pro Ser Ser Ser Gly Pro Ser Thr Asn 
                 245                250                255
Leu Ile Arg Asp Ile Arg Ala Asn Pro Ala Val Gln Trp Ile Gln Ala 
             260                265                270
Ala Leu Val Val Leu Val Ile Tyr Asn Pro Thr Arg Cys Val Ser Gly 
         275                280                285
Thr Asp Asp Trp Arg Cys Pro Ser 
     290                295



<210> 5092
<211> 2676
<212> DNA
<213> Homo sapiens
<308> AK027693
<400> 5092

ctggtgctt  tgcttctcc  tgaccctga  catcctcat  gtggagctg  gcgggctcc  60
ggcccgctt  cccctgtct  ggcgcaact  ccccatcac  ttcgcctgc  atgcggccc  120
cttctgcct  tcggcctcc  tcatctacc  caccaccta  gtccagttc  tgtcccacg  180
ccgttcgcg  gaccacgcc  tcgccgcca  cttcttctc  tgcatcgcg  gtgtggctt  240
cgccaccga  gtggcctgg  cccgggccc  gcccggcga  atcactggc  atatggcca  300
cgtacccgg  ctgctgaag  tgctggaga  cttcgttgc  tgcatcatc  tcgcgttca  360
cagcgaccc  aacctgtac  agcaccagc  ggccctgga  tggtgcgtg  cggtgtacg  420
catctgctt  atcctagcg  ccatcgcca  cctgctgaa  ctgggggag  gcaccaacg  480
gctacccat  cccttcccc  gcttcctgt  ggggctggc  ttgctgtct  tcctcctct  540
tgccaccgc  cttgttctc  ggcccctct  ccagttcga  gagaagtat  gcggccagc  600
tcggcgctc  agagatgta  gctgcagcc  cagccatgc  tattacgtg  gtgcctggg  660
ccgccgact  gctgtggcc  tcctgacgg  catcaacct  ctggcgtat  tggctgacc  720
ggtgcactc  gcccacctg  tttttgtca  ggtctaaga  tctcccaag  ggctcccgt  780
ccctctcca  cctctttgt  cttcttgcc  gagttttct  tatggagta  ttctttcct  840
cgcctttcc  ctgttttcc  cttcctgtc  cccctccct  ccacctttt  ctttccttc  900
caattcctt  cactctaac  agttcttgg  tgcatcttc  tccttccct  tcctcttgc  960
gtttccttc  tgtgttgtt  tgttgccca  atcctgttt  cacccctga  ctgtttctc  1020
ttttctttt  tttcttttt  ttttttttt  aagacggat  ctcactctg  ggcccaggc  1080
ggagtgcag  ggtgcgatc  cagctcact  caacccccg  ctcctgggt  caagcgatt  1140
tcctgcccc  gcctcccaa  tagctggga  gacaggtgt  agctgccgc  cccagcctg  1200
ttctctttt  ccactcttc  tttttctca  ctcttttct  ggttgcctg  cggctttct  1260
atctgcctg  tttgcaagc  ccttctcct  tgtccttgg  agccctgag  cttctttct  1320
tccttgcct  cacccacct  caaaggtgc  gagctcaca  ccacacccc  tgcagccgt  1380
catgccaca  ccccccaag  ggccccatt  ccaaagcat  cctgcccac  ctcgctgtg  1440
cttagtcag  gtgtacgtg  gtgtgtgtg  gtgtttggg  ggtgggggg  gggtagctg  1500
ggattgggc  ctctttctc  cagtggagg  aggtgtgca  tgtacttcc  ctttaaatt  1560
aaaaacata  atatatata  atttggagg  cagtaattt  caatgggcg  gaggcatta  1620
gcaccgacc  tgggtccct  ggccccgcc  ggcactcag  cttgccaga  attggctcc  1680
gaatttttg  caggcttac  gaacaccca  tgcctagag  ccatcttaa  ggaagcagg  1740
gctggatgc  tttcatccc  actattctc  gtggtatga  aaagaaaaa  aaaaaaaag  1800
aggagtcgg  gccgggcgt  gtggctcac  cctgtaatc  cagcacttt  ggagaccaa  1860
tcaggcaat  atctgaagt  aggagttca  gaccagcct  gccaacatg  tgaaagcat  1920
tctctatta  aaatacaaa  attagccgg  cgtggtggc  ggcgcctgt  atcccaggt  1980
tttgggggg  ctgagacag  agaatccct  caacccggg  ggtggaggt  gcagtaagt  2040
aagatggca  cactgtgct  cagcctggg  gacagagcg  gactccatc  caaaaaaaa  2100
aggaatcgg  cgaagaacc  caggatgtt  aagacaact  tctgaagta  ttgtgaggg  2160
cagcgatgt  gccctctgt  ttaagaata  cgtgtcctg  tttggcaga  agaagaaaa  2220
agccactgc  cgctttcaa  gcaagatcg  ccttttctg  tttgttttg  ttttctttc  2280
ttttcctgg  caagaggac  aaaattact  agtggccct  aaagaggga  gtttgtttt  2340
agctgttct  ttttgcccg  aggtgggag  gtggggatt  ctgcgtcct  gctagagga  2400
tggctttgc  tgaatgtgt  gtgcacacg  acgggtgtt  ctgtgtgct  gttgcttct  2460
gctgctgct  cctgcttgt  tgggactca  atacataac  tgatatata  atatatata  2520
aaatgtata  atatatatt  tattttttt  taaatcctt  gagcttctg  ttcctatca  2580
ttcctgttg  taatcgtag  accgttgtc  cttccccca  tcccgtatc  atcatgttc  2640
ttttctttt  aatatcaat  taaaggtaa  agaagg  2676



<210> 5093
<211> 322
<212> PRT
<213> Homo sapiens
<308> Q96S97
<400> 5093

Met Pro Val Thr Val Thr Arg Thr Thr Ile Thr Thr Thr Thr Thr Ser 
  1               5                  10                  15
Ser Ser Gly Leu Gly Ser Pro Met Ile Val Gly Ser Pro Arg Ala Leu 
             20                  25                  30
Thr Gln Pro Leu Gly Leu Leu Arg Leu Leu Gln Leu Val Ser Thr Cys 
         35                  40                  45
Val Ala Phe Ser Leu Val Ala Ser Val Gly Ala Trp Thr Gly Ser Met 
     50                  55                  60
Gly Asn Trp Ser Met Phe Thr Trp Cys Phe Cys Phe Ser Val Thr Leu 
 65                  70                  75                  80
Ile Ile Leu Ile Val Glu Leu Cys Gly Leu Gln Ala Arg Phe Pro Leu 
                 85                  90                  95
Ser Trp Arg Asn Phe Pro Ile Thr Phe Ala Cys Tyr Ala Ala Leu Phe 
             100                105                110
Cys Leu Ser Ala Ser Ile Ile Tyr Pro Thr Thr Tyr Val Gln Phe Leu 
         115                120                125
Ser His Gly Arg Ser Arg Asp His Ala Ile Ala Ala Thr Phe Phe Ser 
     130                135                140
Cys Ile Ala Cys Val Ala Tyr Ala Thr Glu Val Ala Trp Thr Arg Ala 
 145                150                155                160
Arg Pro Gly Glu Ile Thr Gly Tyr Met Ala Thr Val Pro Gly Leu Leu 
                 165                170                175
Lys Val Leu Glu Thr Phe Val Ala Cys Ile Ile Phe Ala Phe Ile Ser 
             180                185                190
Asp Pro Asn Leu Tyr Gln His Gln Pro Ala Leu Glu Trp Cys Val Ala 
         195                200                205
Val Tyr Ala Ile Cys Phe Ile Leu Ala Ala Ile Ala Ile Leu Leu Asn 
     210                215                220
Leu Gly Glu Cys Thr Asn Val Leu Pro Ile Pro Phe Pro Ser Phe Leu 
 225                230                235                240
Ser Gly Leu Ala Leu Leu Ser Val Leu Leu Tyr Ala Thr Ala Leu Val 
                 245                250                255
Leu Trp Pro Leu Tyr Gln Phe Asp Glu Lys Tyr Gly Gly Gln Pro Arg 
             260                265                270
Arg Ser Arg Asp Val Ser Cys Ser Arg Ser His Ala Tyr Tyr Val Cys 
         275                280                285
Ala Trp Asp Arg Arg Leu Ala Val Ala Ile Leu Thr Ala Ile Asn Leu 
     290                295                300
Leu Ala Tyr Val Ala Asp Leu Val His Ser Ala His Leu Val Phe Val 
 305                310                315                320
Lys Val 
                 325



<210> 5094
<211> 412
<212> DNA
<213> Rattus norvegicus
<308> AA866299
<400> 5094

ttttttttt  tttttttca  acatataac  actttattt  gtttggcaa  gggaaaaca  60
gtcatgcac  atctctact  aaacacttt  aaagccaag  aaatgatat  tgaattagt  120
ttgctatct  ctttcttcc  tttttcttt  acatttgaa  agtatagta  cagataagg  180
agttacagg  aaatgtaca  aattttata  tttgattac  ttggcaatt  tgctgtgaa  240
ccttccttt  attaaataa  tagttcagt  attctcaac  tctgggttg  actcgaaac  300
cctttcaca  gggccgcat  acggattat  agctattta  atcatgatt  ataatagca  360
aattatagt  atgaagtag  aaataattt  atggtgggg  caccacaat  tg  412



<210> 5095
<211> 412
<212> DNA
<213> Rattus norvegicus
<308> AA866299
<400> 5095

ttttttttt  tttttttca  acatataac  actttattt  gtttggcaa  gggaaaaca  60
gtcatgcac  atctctact  aaacacttt  aaagccaag  aaatgatat  tgaattagt  120
ttgctatct  ctttcttcc  tttttcttt  acatttgaa  agtatagta  cagataagg  180
agttacagg  aaatgtaca  aattttata  tttgattac  ttggcaatt  tgctgtgaa  240
ccttccttt  attaaataa  tagttcagt  attctcaac  tctgggttg  actcgaaac  300
cctttcaca  gggccgcat  acggattat  agctattta  atcatgatt  ataatagca  360
aattatagt  atgaagtag  aaataattt  atggtgggg  caccacaat  tg  412



<210> 5096
<211> 268
<212> DNA
<213> Rattus norvegicus
<308> AA866306
<400> 5096

ttttttttt  tttgtttct  tttttatcg  tacagcttt  atccaggag  cctgagctc  60
ggccaatcg  gcagccaga  ggaagggct  tggccagct  ttgataaag  ccacccccc  120
caccggtct  cacctctgc  caaactggg  aaatatgag  ggccccatc  ttctgattg  180
gatcctggg  agagggact  cttgaaaac  cagactgtg  cccatgctc  catcttact  240
ccaatgaaa  tatctcatg  atcccaag  268



<210> 5097
<211> 1039
<212> DNA
<213> Homo sapiens
<308> BG291391
<400> 5097

accgcggag  cggggacag  cggagcagg  agtgctctg  tgggtgagg  gcacccagc  60
ccagaggct  gtgctggcc  gcgaggact  cctgtggta  ctggaccgg  atggctcct  120
gcatccggg  tttaactgc  agttcttca  cttctgctg  gggacctgc  accatcggt  180
ctgctgcag  gacctgacc  tgcttatca  cgagaggca  cagaagcac  gcctggcct  240
cagccccaa  accatagca  gcatcgcct  agctgtgat  ctctttgtt  ctgtggttg  300
caccaccat  tgctgcttc  tctgttcct  ttgctacct  taccgccgg  gccagcagc  360
ccagagccc  tttgaaggc  aggagattc  aatgacagg  atcccagtg  agccagtat  420
cccataccc  caggacccc  aagctggcc  tgcaccccc  cagcctggc  tcatgtacc  480
acctagtgg  cctgctccc  aatatccac  ctacccagc  gggccccca  tctacaacc  540
tgcagctcc  cctccctat  ttgccacca  agccctctt  cccgggagc  tgaggaacc  600
gccatgtct  tgctgcccc  tcagtgatg  caaccttgg  agatgccct  atcctgtac  660
tgctctggt  cttggggtg  caggagtca  ccagcagca  cccagacca  gccaagcct  720
ggccctact  cggacagag  cccaggaag  ggacacgga  ctgactaaa  attaggtag  780
gagaaagtt  aacaaaggg  ataaagggg  aaggaggaa  aaaccgggg  taacggccg  840
gaacaaagc  ccgtcgcaa  ataccagga  ggggggcca  gtgttcccc  ggagtgggg  900
aaagagaga  ttcaacgtg  cctaccttg  gtgagtcga  cacagcgag  attaatgtg  960
caaacagaa  gggagagat  gcgacccgt  gtggtagaa  agcacgaca  ggaactaga  1020
cttatagtg  tcaaggagt  1039



<210> 5098
<211> 256
<212> DNA
<213> Rattus norvegicus
<308> AA866358
<400> 5098

ttttttttt  tttttttaa  ataacaacc  ctttattag  gaaacctgt  gggtaggag  60
aaacaacag  tgttcaccc  tggggcttt  ttcttcggg  cccaccaca  aaaggaacc  120
cccaaattt  aacggccct  ccccccagt  cccatgaca  agggtggac  tcaattcaa  180
ttcaaatga  gaaatcctg  ttaaaggct  ttcatttaa  aaacactta  atgataaca  240
atatacccc  tttagg  256



<210> 5099
<211> 256
<212> DNA
<213> Rattus norvegicus
<308> AA866358
<400> 5099

ttttttttt  tttttttaa  ataacaacc  ctttattag  gaaacctgt  gggtaggag  60
aaacaacag  tgttcaccc  tggggcttt  ttcttcggg  cccaccaca  aaaggaacc  120
cccaaattt  aacggccct  ccccccagt  cccatgaca  agggtggac  tcaattcaa  180
ttcaaatga  gaaatcctg  ttaaaggct  ttcatttaa  aaacactta  atgataaca  240
atatacccc  tttagg  256



<210> 5100
<211> 398
<212> DNA
<213> Rattus norvegicus
<308> AA866371
<400> 5100

ttttttttt  tttttttga  agaattatt  ctaattata  ttttctgta  aaaaacgtc  60
atcagacag  agtcaaagg  tgaggtggt  atcaggaac  gggcgggtg  ctccagcag  120
cctctgacc  tctctcgtg  agtccttgc  tagagtccc  ggcgatcca  aggtccagg  180
tgaacaatg  gggtcagag  tggaaggct  agcangaga  tagaggagc  tcagcagag  240
tcgagagaa  gccagagtc  atggtcagg  tgtcctagg  agcaactcc  cagccctca  300
cagccttct  tttctttat  ggaggaccc  cagcttcag  gacactgga  ctgctgggc  360
gaggggcgt  tggaggtga  aggacaccg  atgtcatc  398



<210> 5101
<211> 171
<212> PRT
<213> Rattus norvegicus
<308> BAB22140
<400> 5101

Met Thr Ser Ala Ser Thr Lys Val Gly Glu Ile Phe Ser Ala Ala Gly 
  1               5                  10                  15
Ala Ala Phe Thr Lys Leu Gly Glu Leu Thr Met Gln Leu His Pro Val 
             20                  25                  30
Ser Asp Ser Ser Pro Ala Gly Ala Lys Trp Thr Glu Thr Glu Ile Glu 
         35                  40                  45
Met Leu Arg Ala Ala Val Lys Arg Phe Gly Asp Asp Leu Asn His Ile 
     50                  55                  60
Ser Cys Val Ile Lys Glu Arg Thr Val Ala Gln Ile Lys Thr Thr Val 
 65                  70                  75                  80
Lys Arg Lys Val Tyr Glu Asp Ser Gly Ile Pro Leu Pro Ala Glu Ser 
                 85                  90                  95
Pro Lys Lys Gly Pro Lys Lys Met Thr Ser Gly Val Leu Ser Pro Pro 
             100                105                110
Asn Ala Pro Pro Pro Ser Ser Ser Ser Val Pro Glu Ala Gly Val Pro 
         115                120                125
Pro Ile Lys Lys Gln Lys Ala Asp Val Thr Leu Ser Ala Leu Asn Asp 
     130                135                140
Ser Asp Ala Asn Ser Asp Leu Val Asp Val Glu Gly Leu Gly Glu Thr 
 145                150                155                160
Pro Pro Ala Lys Lys Leu Asn Phe Asp Gln Ala 
                 165                170



<210> 5102
<211> 337
<212> DNA
<213> Homo sapiens
<308> AW408241
<400> 5102

cacgagggc  atttgggga  gatcttaat  acatcagct  tgtcatcaa  gaacggaca  60
tggcccaga  aaaggccac  gtgaaacgc  aggtatatg  agattctgg  atccccctt  120
cagctgagt  acccaagaa  gggcccaag  aggtggcat  tggtgtctt  tcacctcct  180
cagctgccc  tcctcccag  agctccagt  tccctgagg  cgggggtcc  cccataaag  240
aacagaagg  tgatgtgac  ctcagtgct  tgaacgact  cgatgccaa  agtgacgtg  300
tggatattg  agggctagg  gaaactcct  cagctaa  337



<210> 5103
<211> 398
<212> DNA
<213> Rattus norvegicus
<308> AA866371
<400> 5103

ttttttttt  tttttttga  agaattatt  ctaattata  ttttctgta  aaaaacgtc  60
atcagacag  agtcaaagg  tgaggtggt  atcaggaac  gggcgggtg  ctccagcag  120
cctctgacc  tctctcgtg  agtccttgc  tagagtccc  ggcgatcca  aggtccagg  180
tgaacaatg  gggtcagag  tggaaggct  agcangaga  tagaggagc  tcagcagag  240
tcgagagaa  gccagagtc  atggtcagg  tgtcctagg  agcaactcc  cagccctca  300
cagccttct  tttctttat  ggaggaccc  cagcttcag  gacactgga  ctgctgggc  360
gaggggcgt  tggaggtga  aggacaccg  atgtcatc  398



<210> 5104
<211> 171
<212> PRT
<213> Rattus norvegicus
<308> BAB22140
<400> 5104

Met Thr Ser Ala Ser Thr Lys Val Gly Glu Ile Phe Ser Ala Ala Gly 
  1               5                  10                  15
Ala Ala Phe Thr Lys Leu Gly Glu Leu Thr Met Gln Leu His Pro Val 
             20                  25                  30
Ser Asp Ser Ser Pro Ala Gly Ala Lys Trp Thr Glu Thr Glu Ile Glu 
         35                  40                  45
Met Leu Arg Ala Ala Val Lys Arg Phe Gly Asp Asp Leu Asn His Ile 
     50                  55                  60
Ser Cys Val Ile Lys Glu Arg Thr Val Ala Gln Ile Lys Thr Thr Val 
 65                  70                  75                  80
Lys Arg Lys Val Tyr Glu Asp Ser Gly Ile Pro Leu Pro Ala Glu Ser 
                 85                  90                  95
Pro Lys Lys Gly Pro Lys Lys Met Thr Ser Gly Val Leu Ser Pro Pro 
             100                105                110
Asn Ala Pro Pro Pro Ser Ser Ser Ser Val Pro Glu Ala Gly Val Pro 
         115                120                125
Pro Ile Lys Lys Gln Lys Ala Asp Val Thr Leu Ser Ala Leu Asn Asp 
     130                135                140
Ser Asp Ala Asn Ser Asp Leu Val Asp Val Glu Gly Leu Gly Glu Thr 
 145                150                155                160
Pro Pro Ala Lys Lys Leu Asn Phe Asp Gln Ala 
                 165                170



<210> 5105
<211> 337
<212> DNA
<213> Homo sapiens
<308> AW408241
<400> 5105

cacgagggc  atttgggga  gatcttaat  acatcagct  tgtcatcaa  gaacggaca  60
tggcccaga  aaaggccac  gtgaaacgc  aggtatatg  agattctgg  atccccctt  120
cagctgagt  acccaagaa  gggcccaag  aggtggcat  tggtgtctt  tcacctcct  180
cagctgccc  tcctcccag  agctccagt  tccctgagg  cgggggtcc  cccataaag  240
aacagaagg  tgatgtgac  ctcagtgct  tgaacgact  cgatgccaa  agtgacgtg  300
tggatattg  agggctagg  gaaactcct  cagctaa  337



<210> 5106
<211> 466
<212> DNA
<213> Rattus norvegicus
<308> AA866409
<400> 5106

cggccgcaa  ggttttttt  atttttttt  aattttttc  atttttatt  aaagctgta  60
tccaaacca  atccttcaa  tcaaaaagc  gtttcaaac  aatttgtac  aatatcatg  120
taccagtgt  ttaaagata  cctacagac  attataaaa  agcaactat  atacaaaag  180
attctatgg  aaactgttt  tataaaacc  tttagaaat  aacttgttt  atgatagaa  240
ataaaaatt  aattaaccc  aaatacatt  attgctctg  agatgggct  agtgttttg  300
agtcacatt  cttctttga  aaagggcgt  tgaaccagg  actacagta  cagatgcac  360
ccgtaccct  tcactcgag  cctctcatc  ctgggtttg  aaccctttt  ccagaaatg  420
ataagcaaa  cctaccaaa  aggagtgct  ggtcnctta  cttttg  466



<210> 5107
<211> 6871
<212> DNA
<213> Homo sapiens
<308> XM_031553
<400> 5107

cgactcgcc  gtgctgctg  cgccgccga  ggaggggca  agctcaaga  ggcggacaa  60
acgccaggc  gatctcaga  ggccagttc  aagacgaga  catcagatg  tcattcatc  120
ggatcttca  atgcacata  ggatgcatc  ggaccctca  atagtgata  gccaagtcg  180
acacgacct  agagcccaa  aaaacataa  tataggaat  aaagtgccc  tgaaagcct  240
tgtgattct  ctcatcaga  tctctcaag  cctcttctg  aaaacaaac  taaagcatt  300
agtattgga  aaatgagta  agctaagcg  actttaagt  aaaaggaac  ggaagaatt  360
aagaaaaag  aggatgaaa  ggcagctgc  gagatttat  aggagtttc  tgctgcttt  420
gaaggaagt  atggtaata  agtgaaaac  tttgtgcga  ggggtgttg  taatgcagc  480
aaagaagaa  atgaaacag  tgaaaaaag  ggtaaaatc  ataagccat  ttcaagatt  540
gcagatcaa  aaaatcctc  aaatcagtc  tccaatgaa  gaccaccat  tcttcttgt  600
atagaaacc  aaaaacctc  acttaaaaa  ggagagaaa  aaaagaaaa  aagcaattt  660
gaactcttc  aagaagaat  aaagcaaat  caagaggaa  gtgatgaga  acataaaac  720
aaaggcaga  taagtcgat  tgaacctcc  cagtcagat  ctgatggtc  gcgtcgttc  780
atggacgcg  cttcaagaa  aaatagatc  tctggtgtt  ttgatgatt  cgcacctgg  840
tcacatgat  taggagatc  aagcactac  aatttatac  ttggaaaca  taatccaca  900
atgaatgaa  aaatgctgt  ccaagaatt  ggaagattt  gaccgttag  cagtgtgaa  960
atcatgtgg  ctagaactg  tgaagaaag  gccagagag  gaaattgcg  ctttgtggc  1020
tttatgaat  gaagagatg  tgaaagagc  ttaaaaaat  tgaatggaa  aatgattat  1080
tcttttgaa  tgaagttag  ttggggtaa  gctgtacct  ttcctccac  tccaatata  1140
attccgcct  ctatgatgg  acatacgct  cccccacct  catccggac  gccttttaa  1200
gcgcagcct  gagagcggt  aaaaaaccc  aatgctcct  tgttaccgc  acctaaaaa  1260
aaagaggat  ttgagaaga  tctgtcgca  gccatagtc  aagtggtta  cccaacaga  1320
aggaatttg  tcgccctga  acatcgaat  atagagttt  ttgtacgtg  agggccaat  1380
tttgaagct  tgattatga  cagagaaat  aacaatcct  tgttcaggt  cttatttga  1440
aaccagaca  cagcccatg  ttactatag  tggaagctt  attctattc  gcagggaga  1500
tctccaact  aatggcgga  ggaagattt  cgtatgttc  aaaatggat  tttttggag  1560
ccaccacca  taaatccgt  cttgcatgg  atgtcagaa  agcaagaaa  agaagcttt  1620
gtagaggaa  ctagtaaaa  gggagcact  aaggaagaa  agagggata  attggaaga  1680
atcttgcgg  gattaactc  aaggaaaaa  gatattgga  atgcaatgg  tttctgtct  1740
aataatgct  aagctgctg  agaaatagt  gattgcatt  ctgagtcgt  gtccatctt  1800
aagacaccc  ttcctaaaa  gattgccag  ttatatttg  tttctgatg  tttgtacaa  1860
tcttcagcc  aagttgcta  tgcttcata  tatagaaaa  tttttgaaa  aaagttatg  1920
cagatattt  cagacctca  tgccaccta  cgtacaatt  aaggccatt  acaatctga  1980
aactttaag  aacgggtaa  gacttgctt  agagcatgg  aagattggg  aatttatcc  2040
gaaccattt  tgatcaaac  acaaaatat  ttcttagga  ttgtaaata  tattgaaga  2100
aaggaaaca  aggatgttc  agatgacct  gatggtgcc  ccatcgagg  agagcttga  2160
ggtgcacct  tggaagatg  agatggaat  cctattgat  ctactccca  cgatgatct  2220
gatggagtc  ctataaaaa  tcttgatga  gatcttgat  gagtgcctt  ggatgcaac  2280
gaagactca  aaaagaatg  gcctatatt  aaagttgcc  catcaaaat  ggaagctgt  2340
gatgaatct  aattggaag  acaggctgt  acaacttct  aatgggaat  atttgacca  2400
catgaagaa  cagaagaag  agaaaatca  aatcaagaa  aagaaagtg  agatgaaga  2460
gatactcaa  gttccaaat  tgaagaaca  catttgtac  ctaatccaa  caaagaaga  2520
atgactgag  ctaagttct  taagtactc  gaaatgagt  aggaaaaac  agccaaact  2580
cgtgaaatt  agctcaaag  tatgaagtt  caggatgaa  tggaatctg  gaaaagacc  2640
aaaaaacca  gccagagtt  tcaggagca  gtagaacac  acagagata  acttcttca  2700
cgagagaaa  agaaagagt  agaaagaga  cgagaaaga  acaagaaag  taaagaaaa  2760
ttggaatct  gctccaaag  caagaagga  aaagatgag  gtactccga  aaggaagga  2820
aggaagagg  gacacagta  atcccccag  ccatctcgc  gtagcagtg  tagacgagt  2880
aaatcccca  caccaaaat  ggagcgatc  gagcgttca  aaagatctc  taaagagag  2940
tcacggtcc  ggtcatctc  caaagattc  cctagagat  ttagcaaaa  agccaaaag  3000
tcaccatct  gttcaagga  acctaaaag  tctaggcga  cacggtcta  atctcctaa  3060
aaatcagga  agaagtcca  atcccagtc  agatctcca  acaggtctc  taaaaagtc  3120
aagaaaaac  aacactgac  taaattttt  agatgctgt  acttattgg  aatgcgatt  3180
gttttgtgc  tgaacggtc  gttttttaa  aaaacaaaa  atcaaatga  agagcattc  3240
tggggtttt  tgtttgttt  tgtatgcat  tgtaaactc  tgagcaact  catctgtag  3300
tctgtcatt  ttttatatt  tgtaaatta  tttcattgt  gctatttct  aagatgaaa  3360
ttttattgt  ctaatggat  tcatcagaa  tgtgtataa  ggatctgct  acagtagta  3420
tattttgtt  taggatgtt  tgacttagc  aaaataata  agatgtctt  ccccctttt  3480
tagctttga  aatttgaat  agatttcaa  taaaatctg  acagaaaac  ataatgttg  3540
ttttttgcc  caccggtga  attaagtcc  ttaaagtcc  actgagttt  acactactg  3600
tgtgcttct  atacctgat  cactttata  gccccagtg  tcaagtagc  taagtttta  3660
atttactaa  atgactatc  aaattaagg  acctgagac  cctatttgg  ggtttgcta  3720
ccatttgct  ttgataagt  tctcttggg  aatactaat  cccagatat  aaagactag  3780
tagatatgg  atggcgttt  gttagtgga  tgcctggct  aaacatttt  ttcacagaa  3840
caatatgat  tccatacat  caacccatg  tctgagcaa  tacttactt  tagggggaa  3900
ttaaatatc  tttcatttc  tcttctatt  tgaaagaag  ttatttgta  aacaaattt  3960
ctaacaagg  ttggccata  aattctctt  tatgatcgt  gacctttta  aatcttctg  4020
aggctatct  tcaaacact  gcatcagaa  attttttat  agtttgtgt  taaacagct  4080
agttggtcc  cccccactc  caagagact  gggtttagt  atagcttta  gtaaaattt  4140
aaaataaaa  gtttttcag  aaacttcgt  tctaatggt  tgtaaattc  aggtgcaaa  4200
agttgattt  aaccatttg  agagttgaa  tctattatg  aaataaatt  gctacggta  4260
gaggaagaa  taaaacttg  gtaatgttg  tcataatac  gctataaat  taataaagg  4320
ttatgtaga  ttgaactga  actattatt  gtgaatctt  atttcagtt  tttatgtag  4380
cacttcata  actggtttg  tgggttttt  ttttcctcc  taaaagaga  agtagaaaa  4440
tattctaac  atggattat  ttgatttag  ttgcttttt  aaaaaatct  ttcaacttg  4500
tttacttaa  cttgcctag  cacaaaata  gatgtgcac  catggtttg  agagttcct  4560
tattagctg  gcagtgaga  acactattt  caaacggtg  acacctaca  tagctttgg  4620
aatgagcca  tcactgttt  acttaatgg  tcttatcag  atgcaaata  tgcttgaaa  4680
ttatttcct  attcactgt  ttgttagtc  attttgtta  gaaacatta  ttcctaaaa  4740
tttgttcag  ataattaaa  gtgaacatt  ggtgctgat  ctcaaaaac  tacaaatgt  4800
gccatttaa  aagtaacat  tttttctcc  ctgctcatt  cctgggaga  tggaatttt  4860
tataactac  tttctttgc  aaaataacg  tcgtgtcga  ttggtggtg  ttttggcat  4920
ccatcttgc  ctggtttct  gtataggct  agaaataat  ggtcaggta  taatctttc  4980
agtcaagtt  caagggatg  ttatttctc  tcaaaaaaa  acatcctgc  ggattgagt  5040
gaaaatttt  ggtcagttt  gggtgctta  ttgtaatat  tttcctact  cattggagt  5100
tagcagttc  ttttttctg  atccagata  aagtgtcat  gtttatctt  cagtgggtg  5160
aactgactt  cttttggtt  ggtgggtga  gatttctta  gcctgatag  atatatatt  5220
tgtgaagtt  gttaatgta  atattagat  gtattggat  tttttttct  gaattgcaa  5280
tggtattat  agataggtt  tttccagtt  tacttcatg  caaattacc  agagtaaac  5340
tacttaata  tcccatgga  tctatgaaa  tttaatggg  tcagaaatt  gtgacttat  5400
agggggaag  tattctacc  tatttttat  atagcttat  attcatgtt  cttgtctga  5460
ggacactca  gttacagag  aaaatttct  taggttgac  agaatgttc  taagcatgg  5520
cttccagtt  caggaaaga  catgttcta  ctgtggaca  ttactgtcc  ctaccacag  5580
tacgtgcca  agttgtttt  cacagttct  ataaagggc  tgacttagg  tctttaccc  5640
ccaacttaa  gtttataca  agggattgt  tactaggtt  atgacattt  actcccctc  5700
cttctgtag  tgagagaaa  taagtaagt  ttgatctgt  tcttaccaa  gagagacag  5760
cctatgatg  aaaatgatc  cgtctctga  ttttttctt  aacgttata  ttccttatt  5820
cagatagta  gcatatggg  atttctgag  tataacatg  tgagaagtt  gaaattaaa  5880
ctaacacaa  aaaaggcgc  gaatcaaaa  atctttgct  ttatttggc  cagaatgtt  5940
ttggctttt  tgctaaaga  ggcagaaat  actctacac  gacctgatt  ttctttatt  6000
cagaccatt  ttgtgggct  accctgaga  ttttatccc  attagtgaa  cttggaggg  6060
atacttgct  atttatgac  taggtattt  cccccaaac  ttaatattc  tgagcactt  6120
aaaatactt  tgagaaatt  taactgtga  taaatttag  tttattaga  atattctgt  6180
cacatttgc  tccatggtg  cgtaagttc  gaaaaatta  atgaccgtg  caatagttt  6240
tcatcatca  tattgttat  caaaataag  gtaaataaa  ctctgtatt  ccaaagtga  6300
ttaaactgt  ctgatgacc  cacagtgtg  tttctttag  agagaaagt  ggttttaaa  6360
ataaatagt  ccacttttc  aagactgta  agtttacaa  taaggtttt  ttctttgtt  6420
ttttcctct  ctattaagt  ttagtgaaa  gcctaatta  agaaaattg  gcagatact  6480
gtgaagata  tagtataag  ttaaaggaa  acgtgactg  aaaatctca  atttacaaa  6540
tgcttgatc  cttcatatt  cacacgcat  ttttagaat  gattttagg  agtgtttaa  6600
tcattatcc  tttgactta  aatttttgt  accaacttc  taggactta  ataatatat  6660
aataagtac  aatcccagg  gaagtgttg  gatgctaga  taaaaggtg  gaatgtgct  6720
ctgttccgt  agccttgtt  cattgttga  aatttgatg  ctcagtgtt  attcagtac  6780
acctcatgg  gcttcaatg  aaatggatt  tatgtataa  tggtaattt  tatagtttt  6840
tagattgta  attaaatgc  ctcatcatg  c  6871



<210> 5108
<211> 1029
<212> PRT
<213> Homo sapiens
<308> XP_031553
<400> 5108

Met Ala Asp Lys Thr Pro Gly Gly Ser Gln Lys Ala Ser Ser Lys Thr 
  1               5                  10                  15
Arg Ser Ser Asp Val His Ser Ser Gly Ser Ser Asp Ala His Met Asp 
             20                  25                  30
Ala Ser Gly Pro Ser Asp Ser Asp Met Pro Ser Arg Thr Arg Pro Lys 
         35                  40                  45
Ser Pro Arg Lys His Asn Tyr Arg Asn Glu Ser Ala Arg Glu Ser Leu 
     50                  55                  60
Cys Asp Ser Pro His Gln Asn Leu Ser Arg Pro Leu Leu Glu Asn Lys 
 65                  70                  75                  80
Leu Lys Ala Phe Ser Ile Gly Lys Met Ser Thr Ala Lys Arg Thr Leu 
                 85                  90                  95
Ser Lys Lys Glu Gln Glu Glu Leu Lys Lys Lys Glu Asp Glu Lys Ala 
             100                105                110
Ala Ala Glu Ile Tyr Glu Glu Phe Leu Ala Ala Phe Glu Gly Ser Asp 
         115                120                125
Gly Asn Lys Val Lys Thr Phe Val Arg Gly Gly Val Val Asn Ala Ala 
     130                135                140
Lys Glu Glu His Glu Thr Asp Glu Lys Arg Gly Lys Ile Tyr Lys Pro 
 145                150                155                160
Ser Ser Arg Phe Ala Asp Gln Lys Asn Pro Pro Asn Gln Ser Ser Asn 
                 165                170                175
Glu Arg Pro Pro Ser Leu Leu Val Ile Glu Thr Lys Lys Pro Pro Leu 
             180                185                190
Lys Lys Gly Glu Lys Glu Lys Lys Lys Ser Asn Leu Glu Leu Phe Lys 
         195                200                205
Glu Glu Leu Lys Gln Ile Gln Glu Glu Arg Asp Glu Arg His Lys Thr 
     210                215                220
Lys Gly Arg Leu Ser Arg Phe Glu Pro Pro Gln Ser Asp Ser Asp Gly 
 225                230                235                240
Gln Arg Arg Ser Met Asp Ala Pro Ser Arg Arg Asn Arg Ser Ser Gly 
                 245                250                255
Val Leu Asp Asp Tyr Ala Pro Gly Ser His Asp Val Gly Asp Pro Ser 
             260                265                270
Thr Thr Asn Leu Tyr Leu Gly Asn Ile Asn Pro Gln Met Asn Glu Glu 
         275                280                285
Met Leu Cys Gln Glu Phe Gly Arg Phe Gly Pro Leu Ala Ser Val Lys 
     290                295                300
Ile Met Trp Pro Arg Thr Asp Glu Glu Arg Ala Arg Glu Arg Asn Cys 
 305                310                315                320
Gly Phe Val Ala Phe Met Asn Arg Arg Asp Ala Glu Arg Ala Leu Lys 
                 325                330                335
Asn Leu Asn Gly Lys Met Ile Met Ser Phe Glu Met Lys Leu Gly Trp 
             340                345                350
Gly Lys Ala Val Pro Ile Pro Pro His Pro Ile Tyr Ile Pro Pro Ser 
         355                360                365
Met Met Glu His Thr Leu Pro Pro Pro Pro Ser Gly Leu Pro Phe Asn 
     370                375                380
Ala Gln Pro Arg Glu Arg Leu Lys Asn Pro Asn Ala Pro Met Leu Pro 
 385                390                395                400
Pro Pro Lys Asn Lys Glu Asp Phe Glu Lys Thr Leu Ser Gln Ala Ile 
                 405                410                415
Val Lys Val Val Ile Pro Thr Glu Arg Asn Leu Leu Ala Leu Ile His 
             420                425                430
Arg Met Ile Glu Phe Val Val Arg Glu Gly Pro Met Phe Glu Ala Met 
         435                440                445
Ile Met Asn Arg Glu Ile Asn Asn Pro Met Phe Arg Phe Leu Phe Glu 
     450                455                460
Asn Gln Thr Pro Ala His Val Tyr Tyr Arg Trp Lys Leu Tyr Ser Ile 
 465                470                475                480
Leu Gln Gly Asp Ser Pro Thr Lys Trp Arg Thr Glu Asp Phe Arg Met 
                 485                490                495
Phe Lys Asn Gly Ser Phe Trp Arg Pro Pro Pro Leu Asn Pro Tyr Leu 
             500                505                510
His Gly Met Ser Glu Glu Gln Glu Thr Glu Ala Phe Val Glu Glu Pro 
         515                520                525
Ser Lys Lys Gly Ala Leu Lys Glu Glu Gln Arg Asp Lys Leu Glu Glu 
     530                535                540
Ile Leu Arg Gly Leu Thr Pro Arg Lys Asn Asp Ile Gly Asp Ala Met 
 545                550                555                560
Val Phe Cys Leu Asn Asn Ala Glu Ala Ala Glu Glu Ile Val Asp Cys 
                 565                570                575
Ile Thr Glu Ser Leu Ser Ile Leu Lys Thr Pro Leu Pro Lys Lys Ile 
             580                585                590
Ala Arg Leu Tyr Leu Val Ser Asp Val Leu Tyr Asn Ser Ser Ala Lys 
         595                600                605
Val Ala Asn Ala Ser Tyr Tyr Arg Lys Phe Phe Glu Thr Lys Leu Cys 
     610                615                620
Gln Ile Phe Ser Asp Leu Asn Ala Thr Tyr Arg Thr Ile Gln Gly His 
 625                630                635                640
Leu Gln Ser Glu Asn Phe Lys Gln Arg Val Met Thr Cys Phe Arg Ala 
                 645                650                655
Trp Glu Asp Trp Ala Ile Tyr Pro Glu Pro Phe Leu Ile Lys Leu Gln 
             660                665                670
Asn Ile Phe Leu Gly Leu Val Asn Ile Ile Glu Glu Lys Glu Thr Glu 
         675                680                685
Asp Val Pro Asp Asp Leu Asp Gly Ala Pro Ile Glu Glu Glu Leu Asp 
     690                695                700
Gly Ala Pro Leu Glu Asp Val Asp Gly Ile Pro Ile Asp Ala Thr Pro 
 705                710                715                720
Ile Asp Asp Leu Asp Gly Val Pro Ile Lys Ser Leu Asp Asp Asp Leu 
                 725                730                735
Asp Gly Val Pro Leu Asp Ala Thr Glu Asp Ser Lys Lys Asn Glu Pro 
             740                745                750
Ile Phe Lys Val Ala Pro Ser Lys Trp Glu Ala Val Asp Glu Ser Glu 
         755                760                765
Leu Glu Ala Gln Ala Val Thr Thr Ser Lys Trp Glu Leu Phe Asp Gln 
     770                775                780
His Glu Glu Ser Glu Glu Glu Glu Asn Gln Asn Gln Glu Glu Glu Ser 
 785                790                795                800
Glu Asp Glu Glu Asp Thr Gln Ser Ser Lys Ser Glu Glu His His Leu 
                 805                810                815
Tyr Ser Asn Pro Ile Lys Glu Glu Met Thr Glu Ser Lys Phe Ser Lys 
             820                825                830
Tyr Ser Glu Met Ser Glu Glu Lys Arg Ala Lys Leu Arg Glu Ile Glu 
         835                840                845
Leu Lys Val Met Lys Phe Gln Asp Glu Leu Glu Ser Gly Lys Arg Pro 
     850                855                860
Lys Lys Pro Gly Gln Ser Phe Gln Glu Gln Val Glu His Tyr Arg Asp 
 865                870                875                880
Lys Leu Leu Gln Arg Glu Lys Glu Lys Glu Leu Glu Arg Glu Arg Glu 
                 885                890                895
Arg Asp Lys Lys Asp Lys Glu Lys Leu Glu Ser Arg Ser Lys Asp Lys 
             900                905                910
Lys Glu Lys Asp Glu Cys Thr Pro Thr Arg Lys Glu Arg Lys Arg Arg 
         915                920                925
His Ser Thr Ser Pro Ser Pro Ser Arg Ser Ser Ser Gly Arg Arg Val 
     930                935                940
Lys Ser Pro Ser Pro Lys Ser Glu Arg Ser Glu Arg Ser Glu Arg Ser 
 945                950                955                960
His Lys Glu Ser Ser Arg Ser Arg Ser Ser His Lys Asp Ser Pro Arg 
                 965                970                975
Asp Val Ser Lys Lys Ala Lys Arg Ser Pro Ser Gly Ser Arg Thr Pro 
             980                985                990
Lys Arg Ser Arg Arg Ser Arg Ser Arg Ser Pro Lys Lys Ser Gly Lys 
         995                1000                1005
Lys Ser Arg Ser Gln Ser Arg Ser Pro His Arg Ser His Lys Lys Ser 
     1010                1015                1020
Lys Lys Asn Lys His 
 1025



<210> 5109
<211> 537
<212> DNA
<213> Rattus norvegicus
<308> AA866419
<400> 5109

ttttttttt  tttttttaa  tctcttgga  gacattttc  ttgataaca  gcacgaggc  60
gctgtaagt  gggacagtg  gacggttat  ttttttttt  cctagccaa  ctaatgagg  120
gtattaaaa  aaataccta  ctatacatc  tttccgatg  gcctctgcc  tcctttaac  180
tcttctagc  taggtcatt  gagagaact  tgagaatcg  tcagttttg  gtctccctc  240
acccctagg  accaccctc  attgctaaa  ggcttctgc  gcagtgtgg  aactcgact  300
agattattt  atagtaagc  gttgggttt  actgttaac  agaactgtg  gtgtgtgtg  360
ggtttcctt  ttttggttt  gttttgtaa  ggtgaactt  gtattttta  tattatcag  420
ttatatacc  gagagcctg  tatatatat  ttttttttt  ttttgaact  aaaggagaa  480
aaaaaatca  cgaacttaa  gcacatcag  agacaaaaa  cctcgtgcc  aattctt  537



<210> 5110
<211> 265
<212> DNA
<213> Rattus norvegicus
<308> AA866439
<400> 5110

tttttttta  tttttttag  tgacatact  tatttccag  ctacaacca  taaaaacac  60
ttgtaagtt  acactgttc  gttctcata  ctgaaataa  acacagggc  aagacagct  120
gtggactag  tgccgtcct  ccacccaat  tgtcctgag  aggagcctt  aaagataga  180
aggcggacg  gggtagtgg  atgcagagg  gtacgatac  ccagccgta  ggagatgtg  240
ctaaatttt  cacagggac  cttag  265



<210> 5111
<211> 1843
<212> DNA
<213> Homo sapiens
<308> AK057056
<400> 5111

attctcctc  ggacctcac  actctcaga  ctgcttgtc  tggcagaat  tacagttca  60
cccaactct  tgccttacc  ctcccaacc  aacagcatt  gcagtttgc  aaatataca  120
acccaagtc  tgaggggac  gaggacatg  tgctgggcc  aagtctcct  ctcagggct  180
ctctccaat  ccagccctg  cactccttc  tcaccctcc  tggagcctc  tctgctgct  240
gtctatccc  acggccctg  tcccctccc  tcctgccct  caccagctt  ctggacacc  300
tgccctgag  aagggacct  tggttttct  taaacatct  tgaagggct  aggcagtca  360
ggctggctg  cttgtcact  tttatttgg  agccactca  accattccc  agaagaggg  420
cctcagctg  caatctgga  acctggccc  ggtctgggc  gatgtcttc  cttctccta  480
cttcccagt  ttgtgatcc  gtgatgagc  ccaggatgg  cctgtggtc  ctagagcac  540
cctcatgct  tagggtcct  cagccccat  ctttctcta  tgggccctg  tatcctggc  600
cctctctca  ctctgccac  gatctctgt  ccttagttt  cttctctgc  cgggggact  660
accccaaga  catttccag  agcttccca  gtgatgtgg  gccccaagg  tgggctttg  720
cagctgtgg  ccagctcct  agtgctgcc  aggagacac  aggctgctc  gaatgaggt  780
actgcgggc  ccattctca  ccagtggtt  ttgtattgc  ttccagcag  aggaatatc  840
cctgggaac  tgatagaag  gcagattag  agccccacc  aagacccac  gaattagag  900
ttgtggagt  gggccctac  agctggggt  ttaaggagc  ctccaaatg  ttctgacgc  960
taagaatat  ccaactgct  atctgggct  gccattagt  gagcctggg  agggactgg  1020
actggctag  ccaagaaca  gtggaaaac  ccagcctta  ctggactcc  gagattggg  1080
accaccacc  acaaaaacc  accctatag  cgctcctct  ggaagagga  gagaagttg  1140
agggcctgg  gaaagcaca  attgtttgt  tccctgctc  tgctcacct  tctcacttg  1200
cttggtttt  caaaaggct  tgtggatgg  gccagccag  gagggggtg  gagtcctgg  1260
gaggcagga  gcagaagac  ctgactgtt  ctcccttgg  aacctcacc  taggccaga  1320
agcgcctct  caaactgaa  gaaatctta  ctccacaaa  aaagcatcc  aaatcccca  1380
ttcctcctc  tcccaaccc  agggatacc  tgtagacag  gccaaaaaa  agctccaac  1440
cccagcagc  gggaagaga  ccagaagct  cccttcctc  tcatcctgg  ccctcccca  1500
cccccgcca  tactgtgaa  ccccttccc  ctcagcctg  tttcctggt  agggtcctg  1560
agtcatggg  cctggggga  ccccagggc  aggcccatg  gagggaagg  accaagggc  1620
tccttgggc  aactgtcca  ctctcttgt  cactattct  tcctttcca  ttctgtctt  1680
aaaaggctc  ttcctagga  ggatcgggt  ctaggacaa  tgcagtcca  tccaccagc  1740
ctccctgcc  ctgtgtctt  tttcagaca  gagaataac  gtacagtgt  aacttataa  1800
gcgttttta  tggttgtag  ttggaaata  agtatgtca  atg  1843



<210> 5112
<211> 265
<212> DNA
<213> Rattus norvegicus
<308> AA866439
<400> 5112

tttttttta  tttttttag  tgacatact  tatttccag  ctacaacca  taaaaacac  60
ttgtaagtt  acactgttc  gttctcata  ctgaaataa  acacagggc  aagacagct  120
gtggactag  tgccgtcct  ccacccaat  tgtcctgag  aggagcctt  aaagataga  180
aggcggacg  gggtagtgg  atgcagagg  gtacgatac  ccagccgta  ggagatgtg  240
ctaaatttt  cacagggac  cttag  265



<210> 5113
<211> 1843
<212> DNA
<213> Homo sapiens
<308> AK057056
<400> 5113

attctcctc  ggacctcac  actctcaga  ctgcttgtc  tggcagaat  tacagttca  60
cccaactct  tgccttacc  ctcccaacc  aacagcatt  gcagtttgc  aaatataca  120
acccaagtc  tgaggggac  gaggacatg  tgctgggcc  aagtctcct  ctcagggct  180
ctctccaat  ccagccctg  cactccttc  tcaccctcc  tggagcctc  tctgctgct  240
gtctatccc  acggccctg  tcccctccc  tcctgccct  caccagctt  ctggacacc  300
tgccctgag  aagggacct  tggttttct  taaacatct  tgaagggct  aggcagtca  360
ggctggctg  cttgtcact  tttatttgg  agccactca  accattccc  agaagaggg  420
cctcagctg  caatctgga  acctggccc  ggtctgggc  gatgtcttc  cttctccta  480
cttcccagt  ttgtgatcc  gtgatgagc  ccaggatgg  cctgtggtc  ctagagcac  540
cctcatgct  tagggtcct  cagccccat  ctttctcta  tgggccctg  tatcctggc  600
cctctctca  ctctgccac  gatctctgt  ccttagttt  cttctctgc  cgggggact  660
accccaaga  catttccag  agcttccca  gtgatgtgg  gccccaagg  tgggctttg  720
cagctgtgg  ccagctcct  agtgctgcc  aggagacac  aggctgctc  gaatgaggt  780
actgcgggc  ccattctca  ccagtggtt  ttgtattgc  ttccagcag  aggaatatc  840
cctgggaac  tgatagaag  gcagattag  agccccacc  aagacccac  gaattagag  900
ttgtggagt  gggccctac  agctggggt  ttaaggagc  ctccaaatg  ttctgacgc  960
taagaatat  ccaactgct  atctgggct  gccattagt  gagcctggg  agggactgg  1020
actggctag  ccaagaaca  gtggaaaac  ccagcctta  ctggactcc  gagattggg  1080
accaccacc  acaaaaacc  accctatag  cgctcctct  ggaagagga  gagaagttg  1140
agggcctgg  gaaagcaca  attgtttgt  tccctgctc  tgctcacct  tctcacttg  1200
cttggtttt  caaaaggct  tgtggatgg  gccagccag  gagggggtg  gagtcctgg  1260
gaggcagga  gcagaagac  ctgactgtt  ctcccttgg  aacctcacc  taggccaga  1320
agcgcctct  caaactgaa  gaaatctta  ctccacaaa  aaagcatcc  aaatcccca  1380
ttcctcctc  tcccaaccc  agggatacc  tgtagacag  gccaaaaaa  agctccaac  1440
cccagcagc  gggaagaga  ccagaagct  cccttcctc  tcatcctgg  ccctcccca  1500
cccccgcca  tactgtgaa  ccccttccc  ctcagcctg  tttcctggt  agggtcctg  1560
agtcatggg  cctggggga  ccccagggc  aggcccatg  gagggaagg  accaagggc  1620
tccttgggc  aactgtcca  ctctcttgt  cactattct  tcctttcca  ttctgtctt  1680
aaaaggctc  ttcctagga  ggatcgggt  ctaggacaa  tgcagtcca  tccaccagc  1740
ctccctgcc  ctgtgtctt  tttcagaca  gagaataac  gtacagtgt  aacttataa  1800
gcgttttta  tggttgtag  ttggaaata  agtatgtca  atg  1843



<210> 5114
<211> 293
<212> DNA
<213> Rattus norvegicus
<308> AA866444
<400> 5114

ttttttttt  tttttttag  aacttacat  ttatttcat  tacaaaggg  ccttgtggc  60
gtgaggtga  atacggcaa  cagcactcc  gtgagcacc  ggaaaaggc  gttgaagca  120
atgcagctg  cagtgagca  gccctgggg  ccaggatag  cacgcagga  ggcacaggc  180
tggaagagc  tctctctgc  tccctccaa  ttgggacca  acccccggc  cccacaaag  240
cacatgtgc  ccggacatt  gaaaatagc  cagcccccc  tgaaaaccc  aca  293



<210> 5115
<211> 534
<212> DNA
<213> Rattus norvegicus
<308> AA866454
<400> 5115

ttttttttt  tttttttcc  agtgtgtgt  ctttattct  cccagaagc  atgttgact  60
ccttctgca  gctgatgga  ggaagggcg  tgcccttca  gtggactgt  ctgtggacg  120
atctgactg  gaggagccc  agtaccaag  agaatggag  tgagaagcc  gggcgctca  180
taacagagc  ggggacaag  ggcctcctt  gaaggtgtg  atgttctgg  tgttctgag  240
taacaggcc  gtccacatg  cctgcatgt  cattgatgg  ctcccaggc  gctagtaga  300
gtgaggctg  tgctggcac  acgttactg  aagcagcaa  agagttcgc  tatccacaa  360
gctgagcat  tctaccact  agacatgca  actccttgt  tcgcagagc  cctgggtca  420
cagcggagg  atcacctgn  gggcgcagg  atgcgatcg  gaccgttcc  tccaactta  480
tcgaaacct  ccgctgccg  ggtgctaaa  aaaaaaaaa  aaaccctcg  gccg  534



<210> 5116
<211> 2174
<212> DNA
<213> Homo sapiens
<308> AK000261
<400> 5116

catgtgggc  ctgggtcaa  caggttttg  caacctcac  gagggactg  aagtgtggc  60
ggggatcat  ctgcctgtg  tgggcatca  gtctctgtc  ccctttgcc  tcacatacc  120
ggatcggct  ctcctgatg  atcccaacc  taccaaggg  ttcggcatg  ttggcccca  180
ggacttctt  ccacttctg  actatgcct  tatgccgaa  aactccctg  cacccagcc  240
gcaggagca  ctgtgtcag  tctaccccc  actgaaagt  ctggcattt  gagcaaagc  300
ggattccac  ctgcatacc  acttccctt  tttcctgtc  agagccacc  ctagctgtc  360
ccctgagat  aagaaagag  tcctgagca  cctgactga  tgcctgacg  tggaccccc  420
cagtgccag  gtctggagg  agctgtacc  taagcacct  tcacagtcc  gccttctgc  480
ggagcactt  ctcagctcc  gggagcaga  tcccaagaa  gtacagaag  ctttgcaag  540
aaccattca  tccctcaag  ttaccaacc  ggagctgct  aggaagggt  gcagtaaca  600
ccaggatgt  gtcacctgt  acatggcct  caagggcct  ttgcagcag  ttcagggtc  660
tcggctgcc  tggacgcgg  tcctcctgt  gctgctggt  ttcgctgta  gcttcctgt  720
ccatgacct  cggtcacac  gctccttcc  ggcctccct  actggccgg  tgcttcgat  780
atctggctt  ttacctgct  gccaacaag  gtgtgccaa  ctctactcc  acagtctgc  840
aggctacag  tggctgggg  agacactgc  gctctgggg  tcccacctg  tcaccgtgg  900
gcggcccag  ttgcagctg  cctgggctc  caccaatgc  acagtcagc  tcctttctg  960
ccactgtgc  tctcacctt  cgtggtttg  tgacagtct  accagtctc  ctcagaggc  1020
acagatcca  ctccccgat  ccgtgaatc  gctactccg  tatctgaga  agctgcccc  1080
gcttttcca  cagaatgtg  tgctgccac  gtggcacct  ttgcttgag  ccctggcct  1140
ggcccagga  cactgccat  aggcatgca  aggtgaggt  acctgggac  gcatgaaga  1200
acagctcag  gaggctgtc  actggacct  gctttgcct  caggacatt  cagtggctt  1260
cttggactg  gcacttgcc  tgatatccc  gcagtaggc  ctgccttcc  ggccactga  1320
ttctgcatg  gtagaccat  caagactgc  gcgggtaga  ggtggcagt  cttcatggg  1380
gtcttttta  cttggtgcc  gagttctct  ctaggcaag  ggccagttg  ctccacctc  1440
gttcttcca  ctttggtgg  gacagggcc  agcagcatc  cagcctcct  cccacaatt  1500
cactgaaca  ttttctggc  ctactgcac  tggccccca  cctccatcc  tgtgctggt  1560
gcctctcac  actccgccc  tgccctctg  cttccactt  cttccatct  atttctaaa  1620
cccaaacag  tcatctcta  aaagataga  ctcccagca  gtggcttct  tgttcttct  1680
acaaatgat  cctgcttct  cagacttta  cagcctcct  ttcccattc  tggtcacag  1740
tctagccac  gcagaagga  aggggcttc  agaagaata  agcaccgca  tgggaaaca  1800
cagcctcac  tccacctga  gcctgggtg  ggctgtcag  ggacatggg  agctggatg  1860
aaatgcctc  cacttcaaa  tgcccagcc  gccccaaat  cctctaagc  cctccctgt  1920
ccctccctt  tagtcctac  tcttccaac  ttccattcc  catcatgct  ggggtcttg  1980
tcacaaggc  cagcttctc  ccactgtcc  tccctccta  catctgtag  gcagagcac  2040
ggcagttgt  tgccttggg  ccagggaac  ctccatcaa  ctgagacag  actcagtat  2100
tggttcttg  gtatgccct  ccaggtgga  taaaggaca  agatttgaa  aaaaaaaaa  2160
aaaaaaaaa  aaaa  2174



<210> 5117
<211> 432
<212> PRT
<213> Homo sapiens
<308> AK000261
<400> 5117

Met Trp Ala Leu Gly Gln Ala Gly Phe Ala Asn Leu Thr Glu Gly Leu 
  1               5                  10                  15
Lys Val Trp Leu Gly Ile Met Leu Pro Val Leu Gly Ile Lys Ser Leu 
             20                  25                  30
Ser Pro Phe Ala Ile Thr Tyr Leu Asp Arg Leu Leu Leu Met His Pro 
         35                  40                  45
Asn Leu Thr Lys Gly Phe Gly Met Ile Gly Pro Lys Asp Phe Phe Pro 
     50                  55                  60
Leu Leu Asp Tyr Ala Tyr Met Pro Asn Asn Ser Leu Thr Pro Ser Leu 
 65                  70                  75                  80
Gln Glu Gln Leu Cys Gln Leu Tyr Pro Arg Leu Lys Val Leu Ala Phe 
                 85                  90                  95
Gly Ala Lys Pro Asp Ser Thr Leu His Thr Tyr Phe Pro Ser Phe Leu 
             100                105                110
Ser Arg Ala Thr Pro Ser Cys Pro Pro Glu Met Lys Lys Glu Leu Leu 
         115                120                125
Ser Ser Leu Thr Glu Cys Leu Thr Val Asp Pro Leu Ser Ala Ser Val 
     130                135                140
Trp Arg Gln Leu Tyr Pro Lys His Leu Ser Gln Ser Ser Leu Leu Leu 
 145                150                155                160
Glu His Leu Leu Ser Ser Trp Glu Gln Ile Pro Lys Lys Val Gln Lys 
                 165                170                175
Ser Leu Gln Glu Thr Ile Gln Ser Leu Lys Leu Thr Asn Gln Glu Leu 
             180                185                190
Leu Arg Lys Gly Ser Ser Asn Asn Gln Asp Val Val Thr Cys Asp Met 
         195                200                205
Ala Cys Lys Gly Leu Leu Gln Gln Val Gln Gly Pro Arg Leu Pro Trp 
     210                215                220
Thr Arg Leu Leu Leu Leu Leu Leu Val Phe Ala Val Gly Phe Leu Cys 
 225                230                235                240
His Asp Leu Arg Ser His Ser Ser Phe Gln Ala Ser Leu Thr Gly Arg 
                 245                250                255
Leu Leu Arg Ser Ser Gly Phe Leu Pro Ala Ser Gln Gln Ala Cys Ala 
             260                265                270
Lys Leu Tyr Ser Tyr Ser Leu Gln Gly Tyr Ser Trp Leu Gly Glu Thr 
         275                280                285
Leu Pro Leu Trp Gly Ser His Leu Leu Thr Val Val Arg Pro Ser Leu 
     290                295                300
Gln Leu Ala Trp Ala His Thr Asn Ala Thr Val Ser Phe Leu Ser Ala 
 305                310                315                320
His Cys Ala Ser His Leu Ala Trp Phe Gly Asp Ser Leu Thr Ser Leu 
                 325                330                335
Ser Gln Arg Leu Gln Ile Gln Leu Pro Asp Ser Val Asn Gln Leu Leu 
             340                345                350
Arg Tyr Leu Arg Glu Leu Pro Leu Leu Phe His Gln Asn Val Leu Leu 
         355                360                365
Pro Leu Trp His Leu Leu Leu Glu Ala Leu Ala Trp Ala Gln Glu His 
     370                375                380
Cys His Glu Ala Cys Arg Gly Glu Val Thr Trp Asp Cys Met Lys Thr 
 385                390                395                400
Gln Leu Ser Glu Ala Val His Trp Thr Trp Leu Cys Leu Gln Asp Ile 
                 405                410                415
Thr Val Ala Phe Leu Asp Trp Ala Leu Ala Leu Ile Ser Gln Gln Ter 
             420                425                430



<210> 5118
<211> 534
<212> DNA
<213> Rattus norvegicus
<308> AA866454
<400> 5118

ttttttttt  tttttttcc  agtgtgtgt  ctttattct  cccagaagc  atgttgact  60
ccttctgca  gctgatgga  ggaagggcg  tgcccttca  gtggactgt  ctgtggacg  120
atctgactg  gaggagccc  agtaccaag  agaatggag  tgagaagcc  gggcgctca  180
taacagagc  ggggacaag  ggcctcctt  gaaggtgtg  atgttctgg  tgttctgag  240
taacaggcc  gtccacatg  cctgcatgt  cattgatgg  ctcccaggc  gctagtaga  300
gtgaggctg  tgctggcac  acgttactg  aagcagcaa  agagttcgc  tatccacaa  360
gctgagcat  tctaccact  agacatgca  actccttgt  tcgcagagc  cctgggtca  420
cagcggagg  atcacctgn  gggcgcagg  atgcgatcg  gaccgttcc  tccaactta  480
tcgaaacct  ccgctgccg  ggtgctaaa  aaaaaaaaa  aaaccctcg  gccg  534



<210> 5119
<211> 2174
<212> DNA
<213> Homo sapiens
<308> AK000261
<400> 5119

catgtgggc  ctgggtcaa  caggttttg  caacctcac  gagggactg  aagtgtggc  60
ggggatcat  ctgcctgtg  tgggcatca  gtctctgtc  ccctttgcc  tcacatacc  120
ggatcggct  ctcctgatg  atcccaacc  taccaaggg  ttcggcatg  ttggcccca  180
ggacttctt  ccacttctg  actatgcct  tatgccgaa  aactccctg  cacccagcc  240
gcaggagca  ctgtgtcag  tctaccccc  actgaaagt  ctggcattt  gagcaaagc  300
ggattccac  ctgcatacc  acttccctt  tttcctgtc  agagccacc  ctagctgtc  360
ccctgagat  aagaaagag  tcctgagca  cctgactga  tgcctgacg  tggaccccc  420
cagtgccag  gtctggagg  agctgtacc  taagcacct  tcacagtcc  gccttctgc  480
ggagcactt  ctcagctcc  gggagcaga  tcccaagaa  gtacagaag  ctttgcaag  540
aaccattca  tccctcaag  ttaccaacc  ggagctgct  aggaagggt  gcagtaaca  600
ccaggatgt  gtcacctgt  acatggcct  caagggcct  ttgcagcag  ttcagggtc  660
tcggctgcc  tggacgcgg  tcctcctgt  gctgctggt  ttcgctgta  gcttcctgt  720
ccatgacct  cggtcacac  gctccttcc  ggcctccct  actggccgg  tgcttcgat  780
atctggctt  ttacctgct  gccaacaag  gtgtgccaa  ctctactcc  acagtctgc  840
aggctacag  tggctgggg  agacactgc  gctctgggg  tcccacctg  tcaccgtgg  900
gcggcccag  ttgcagctg  cctgggctc  caccaatgc  acagtcagc  tcctttctg  960
ccactgtgc  tctcacctt  cgtggtttg  tgacagtct  accagtctc  ctcagaggc  1020
acagatcca  ctccccgat  ccgtgaatc  gctactccg  tatctgaga  agctgcccc  1080
gcttttcca  cagaatgtg  tgctgccac  gtggcacct  ttgcttgag  ccctggcct  1140
ggcccagga  cactgccat  aggcatgca  aggtgaggt  acctgggac  gcatgaaga  1200
acagctcag  gaggctgtc  actggacct  gctttgcct  caggacatt  cagtggctt  1260
cttggactg  gcacttgcc  tgatatccc  gcagtaggc  ctgccttcc  ggccactga  1320
ttctgcatg  gtagaccat  caagactgc  gcgggtaga  ggtggcagt  cttcatggg  1380
gtcttttta  cttggtgcc  gagttctct  ctaggcaag  ggccagttg  ctccacctc  1440
gttcttcca  ctttggtgg  gacagggcc  agcagcatc  cagcctcct  cccacaatt  1500
cactgaaca  ttttctggc  ctactgcac  tggccccca  cctccatcc  tgtgctggt  1560
gcctctcac  actccgccc  tgccctctg  cttccactt  cttccatct  atttctaaa  1620
cccaaacag  tcatctcta  aaagataga  ctcccagca  gtggcttct  tgttcttct  1680
acaaatgat  cctgcttct  cagacttta  cagcctcct  ttcccattc  tggtcacag  1740
tctagccac  gcagaagga  aggggcttc  agaagaata  agcaccgca  tgggaaaca  1800
cagcctcac  tccacctga  gcctgggtg  ggctgtcag  ggacatggg  agctggatg  1860
aaatgcctc  cacttcaaa  tgcccagcc  gccccaaat  cctctaagc  cctccctgt  1920
ccctccctt  tagtcctac  tcttccaac  ttccattcc  catcatgct  ggggtcttg  1980
tcacaaggc  cagcttctc  ccactgtcc  tccctccta  catctgtag  gcagagcac  2040
ggcagttgt  tgccttggg  ccagggaac  ctccatcaa  ctgagacag  actcagtat  2100
tggttcttg  gtatgccct  ccaggtgga  taaaggaca  agatttgaa  aaaaaaaaa  2160
aaaaaaaaa  aaaa  2174



<210> 5120
<211> 432
<212> PRT
<213> Homo sapiens
<308> AK000261
<400> 5120

Met Trp Ala Leu Gly Gln Ala Gly Phe Ala Asn Leu Thr Glu Gly Leu 
  1               5                  10                  15
Lys Val Trp Leu Gly Ile Met Leu Pro Val Leu Gly Ile Lys Ser Leu 
             20                  25                  30
Ser Pro Phe Ala Ile Thr Tyr Leu Asp Arg Leu Leu Leu Met His Pro 
         35                  40                  45
Asn Leu Thr Lys Gly Phe Gly Met Ile Gly Pro Lys Asp Phe Phe Pro 
     50                  55                  60
Leu Leu Asp Tyr Ala Tyr Met Pro Asn Asn Ser Leu Thr Pro Ser Leu 
 65                  70                  75                  80
Gln Glu Gln Leu Cys Gln Leu Tyr Pro Arg Leu Lys Val Leu Ala Phe 
                 85                  90                  95
Gly Ala Lys Pro Asp Ser Thr Leu His Thr Tyr Phe Pro Ser Phe Leu 
             100                105                110
Ser Arg Ala Thr Pro Ser Cys Pro Pro Glu Met Lys Lys Glu Leu Leu 
         115                120                125
Ser Ser Leu Thr Glu Cys Leu Thr Val Asp Pro Leu Ser Ala Ser Val 
     130                135                140
Trp Arg Gln Leu Tyr Pro Lys His Leu Ser Gln Ser Ser Leu Leu Leu 
 145                150                155                160
Glu His Leu Leu Ser Ser Trp Glu Gln Ile Pro Lys Lys Val Gln Lys 
                 165                170                175
Ser Leu Gln Glu Thr Ile Gln Ser Leu Lys Leu Thr Asn Gln Glu Leu 
             180                185                190
Leu Arg Lys Gly Ser Ser Asn Asn Gln Asp Val Val Thr Cys Asp Met 
         195                200                205
Ala Cys Lys Gly Leu Leu Gln Gln Val Gln Gly Pro Arg Leu Pro Trp 
     210                215                220
Thr Arg Leu Leu Leu Leu Leu Leu Val Phe Ala Val Gly Phe Leu Cys 
 225                230                235                240
His Asp Leu Arg Ser His Ser Ser Phe Gln Ala Ser Leu Thr Gly Arg 
                 245                250                255
Leu Leu Arg Ser Ser Gly Phe Leu Pro Ala Ser Gln Gln Ala Cys Ala 
             260                265                270
Lys Leu Tyr Ser Tyr Ser Leu Gln Gly Tyr Ser Trp Leu Gly Glu Thr 
         275                280                285
Leu Pro Leu Trp Gly Ser His Leu Leu Thr Val Val Arg Pro Ser Leu 
     290                295                300
Gln Leu Ala Trp Ala His Thr Asn Ala Thr Val Ser Phe Leu Ser Ala 
 305                310                315                320
His Cys Ala Ser His Leu Ala Trp Phe Gly Asp Ser Leu Thr Ser Leu 
                 325                330                335
Ser Gln Arg Leu Gln Ile Gln Leu Pro Asp Ser Val Asn Gln Leu Leu 
             340                345                350
Arg Tyr Leu Arg Glu Leu Pro Leu Leu Phe His Gln Asn Val Leu Leu 
         355                360                365
Pro Leu Trp His Leu Leu Leu Glu Ala Leu Ala Trp Ala Gln Glu His 
     370                375                380
Cys His Glu Ala Cys Arg Gly Glu Val Thr Trp Asp Cys Met Lys Thr 
 385                390                395                400
Gln Leu Ser Glu Ala Val His Trp Thr Trp Leu Cys Leu Gln Asp Ile 
                 405                410                415
Thr Val Ala Phe Leu Asp Trp Ala Leu Ala Leu Ile Ser Gln Gln Ter 
             420                425                430



<210> 5121
<211> 554
<212> DNA
<213> Rattus norvegicus
<308> AA866471
<400> 5121

ttttttttt  tttttttaa  attgctgaa  tccatttta  tttgtatgt  acattttca  60
ataaaagct  aatgttata  agtatttac  aaactctta  gcaaaaaat  tattattta  120
cctattttt  acaagaatt  tatacaaat  tatataaaa  aattaaatt  ccctgaaaa  180
tctaatgag  gaaaaatat  ccttctgta  tgctttaat  tctaatgca  acatttctt  240
aaacatcaa  gatttctga  aatctaaat  tgtaagtat  ggtgctagg  cactgtgag  300
agacgggtg  atttcccat  tctctcatg  ctcacaaag  tatcaacct  tgagctcct  360
cctaagtgc  tgaaaatga  ctggcataa  ccagtgtca  taggaggtc  cagtgatat  420
tgcattgaa  cgtatactt  tatctttcc  aaaatagca  gaatgttga  taattccat  480
cgttccaaa  cctgggcat  aaggcttag  atgtaataa  acttgggta  tcttcaaca  540
ataagccac  gcat  554



<210> 5122
<211> 555
<212> PRT
<213> Rattus norvegicus
<308> AAH08539
<400> 5122

Met Asp Asn Glu Ile Gln Lys Gln Phe Glu Glu Leu Tyr Asn Leu Ile 
  1               5                  10                  15
Glu Asp Pro Tyr Pro Arg Val Arg Ser Thr Gly Ile Leu Gly Val Cys 
             20                  25                  30
Lys Ile Ser Ser Lys Tyr Trp Glu Met Met Pro Pro Asn Ile Leu Val 
         35                  40                  45
Asp Phe Leu Lys Lys Val Thr Gly Glu Leu Ala Phe Asp Ile Ser Ser 
     50                  55                  60
Ala Asp Val Arg Cys Ser Val Phe Lys Cys Leu Pro Ile Ile Leu Asp 
 65                  70                  75                  80
Asn Lys Leu Ser His Pro Leu Leu Glu Gln Leu Leu Pro Thr Leu Arg 
                 85                  90                  95
Tyr Ser Leu His Asp Asn Ser Glu Lys Val Arg Val Ala Phe Val Asp 
             100                105                110
Leu Leu Leu Lys Ile Lys Ala Val Arg Ala Ala Lys Phe Trp Lys Ile 
         115                120                125
Cys Pro Met Glu Asp Ile Leu Val Arg Leu Glu Met Asp Ser Arg Pro 
     130                135                140
Val Ser Arg Arg Leu Val Ser Leu Ile Phe Asn Ser Phe Leu Pro Val 
 145                150                155                160
Asn Gln Pro Glu Glu Val Trp Cys Glu Arg Cys Val Thr Leu Ile Gln 
                 165                170                175
Met Asn Arg Ala Ala Ala Arg Arg Phe Tyr Gln Tyr Ala His Glu His 
             180                185                190
Thr Ala Ser Thr Asn Ile Ala Lys Leu Ile His Val Ile Arg His Cys 
         195                200                205
Leu Asn Ala Cys Ile Gln Arg Thr Leu Arg Glu Gly Ser Glu Ala His 
     210                215                220
Lys Glu Cys Glu Lys Glu Asn Ala Ser Val Leu Asp Lys Thr Leu Ser 
 225                230                235                240
Val Asn Asp Thr Ala Ser Met Ala Gly Leu Leu Glu Ile Ile Val Ile 
                 245                250                255
Leu Trp Lys Asn Ile His Arg Ser Leu Glu Asn Asn Lys Glu Ala Lys 
             260                265                270
Ile Tyr Thr Ile Asn Lys Phe Ala Ala Val Leu Pro Glu Tyr Leu Lys 
         275                280                285
Val Phe Lys Asp Glu Arg Cys Lys Ile Pro Leu Phe Met Leu Met Ser 
     290                295                300
Phe Leu Pro Ala Ser Ala Val Pro Val Phe Ser Cys Gly Val Ile Ser 
 305                310                315                320
Val Leu Arg Asn Gln Glu Ser Val Thr Gly Arg Ser Tyr Cys Thr Leu 
                 325                330                335
Leu Asp Cys Leu Cys Ser Trp Gly Gln Val Gly His Val Leu Glu Leu 
             340                345                350
Ile Val Asp Trp Leu Pro Thr Val Pro Pro Gln Ala Lys Ser Asn Leu 
         355                360                365
Ala Ser Lys Arg Lys Val Glu Ile Asn Asp Thr Cys Ser Val Lys Pro 
     370                375                380
Glu Leu Ala Leu Leu Tyr Met Glu Tyr Leu Leu Thr His Pro Lys Asn 
 385                390                395                400
Arg Glu Cys Leu Leu Ser Val Pro Gln Lys Lys Leu Asn Gln Leu Leu 
                 405                410                415
Lys Ala Leu Glu Gly Ser Lys Ala Glu Leu Glu Ser Phe Leu Gln Ser 
             420                425                430
Pro Ser Gly Asn Pro Leu Asn Phe Asn Lys Ala Thr Ala Leu His Ala 
         435                440                445
Phe Gly Leu Tyr Cys Arg Met Ser Val His Leu Gln Tyr Lys Phe Cys 
     450                455                460
Ser Glu Glu Lys Ile His Leu Ser Ile Leu Asp Asp Thr Gly Ser Trp 
 465                470                475                480
Leu Glu Asn Lys Val Leu Pro Leu Leu Glu Asp Gln Glu Glu Glu Tyr 
                 485                490                495
Leu Lys Leu Arg Lys Asp Val Tyr Gln Gln Ile Ile Gln Thr Tyr Leu 
             500                505                510
Ala Val Cys Lys Asp Val Val Met Val Gly Leu Gly Asp Pro Lys Phe 
         515                520                525
Gln Met Gln Leu Leu Gln Arg Ser Phe Gly Ile Met Lys Thr Val Lys 
     530                535                540
Gly Phe Phe Met Phe His Tyr Phe Leu Ala Phe 
 545                550                555



<210> 5123
<211> 2403
<212> DNA
<213> Homo sapiens
<308> AK022744
<400> 5123

ttgttgttt  ttgaagcat  tcctattag  gatccaaac  ttcatgcta  tggaatgga  60
agtgaaatc  agaaacagt  tgaagagct  tatagcctt  tagaagatc  ttacccgat  120
gtccgttcc  cagggatcc  tggtgtttg  aaaataact  ctaagtact  ggaaatgat  180
cccccgacc  ttcttattg  cctcctgaa  aaggtgact  gggaactgg  atttgacac  240
agctcagct  atgttcgtt  ttctgtctt  aagtgtctg  caatgattt  ggacaacaa  300
ctgagccac  cattgttag  gcagctcct  ccagctctc  gatacagtc  ccacgacaa  360
tcggagaaa  tgagggtag  ttttgtgga  atgctgttg  agatcaaag  tgtgagggc  420
gctaagttt  ggaaaatat  tcccatgga  cacattctg  ttcgtctgg  aactgattc  480
cgacctgtg  ctcggcgcc  ggtgagcct  atctttaat  ctttcctgc  tgtgaatca  540
ccggaggag  tctggtgcg  gcgctgtgt  accctggtg  agatgaacc  cgccgctgc  600
aggaggttc  atcagtacg  ccacgaaca  accgcctgc  ccaacatag  aaagctgat  660
cacgttatt  gtcattgct  aaatgcctg  atccagagg  cagtgagag  gcctccaga  720
gacgaggag  aagaggacg  aagggagaa  gagaatgtg  ctgttctgg  caaaacact  780
tcagtaaac  atgttgcat  catggcagg  ttactagaa  tcattgtga  tctctggaa  840
agtattgac  gaagtatgg  aaataataa  gaggccaaa  tttacacga  taacaagtt  900
gcctctgtg  ttccagagt  tctgaaagt  tttaaggat  atcgctgca  gatcccttt  960
ttcatgcta  tgtccttta  gccggcctc  gctgtcccc  cattcagct  tggtgtgat  1020
tccacgctg  gaagccggg  ggagggcgc  gtggacaag  gctactgca  tttgttgga  1080
tgcctctgc  cctgggggc  ggtggggca  attctggag  ttgttgaca  ctggctgcc  1140
acagagcat  cccaggcca  gagcaacac  gcttctaaa  gtagggtgc  gatccatga  1200
acacgccca  tcaaacctg  attggcatt  gtctacatt  agtatctgc  gactcatcc  1260
aagaaccgc  agtgcttgc  ctctgctcc  cggaagaaa  ttaaccatc  tttgaaagc  1320
cttgaaacg  caaaggcag  tctggagtc  cttctgcag  caccgggtg  gaagcctcg  1380
ggcttcagt  aagcagctg  cccgcgagc  tttggtctc  actgtcgcc  gagcatcca  1440
cttcagcac  agttctgct  agaaggaaa  gtgtatttg  ccatgttgg  agacactgg  1500
ttttggtta  aaagcaaaa  tttatcttt  attcaagat  aagaagaag  ctacctgaa  1560
cttcatagg  tcatttatc  gcaaattat  cagacctac  tgactgtgt  taaagatgt  1620
gttatggta  gccttggtg  ccatcagtt  cagatgcaa  tcttacagc  gagtcttgg  1680
atcatgcaa  cagtgaagg  attttttta  gtttcatta  ttcttgaca  tctgaaaga  1740
ataactgga  gttccttga  tcagaaaac  gattcagat  aagaagttg  aatgctgtt  1800
gacacagtc  agaaagtat  tcagaaaat  ttggaatgt  ttgcacgga  cttcaggaa  1860
cagccggaa  aaggcctgc  gctgcttta  tctgttcag  ggcctcttc  tgagttcat  1920
actgctgtt  agtctcggc  cacagacac  cctgtgcac  ggggtgtac  ttctactct  1980
atcgctggg  ctgtggttg  gataagtca  cagctacgg  aggtttctg  cgtagaaga  2040
cttacccct  cagagcatc  ttctgatct  ccaccattt  caaggtgtt  aataggaat  2100
ataataaag  cttcgaatg  ggtcaggtc  tttttggat  aattaaagg  atgtgtggc  2160
tctaatgat  ttgaaggca  tgtgtgcct  acggctgct  tgcatatta  cctggttat  2220
aatgcaggt  aacataaaa  ctcaaaagt  agggaggtt  cagccactg  tcacagaaa  2280
ctaaagaca  tcatggaaa  tactttgga  gaggatagc  ttgaaagat  tctctatga  2340
tcatcatca  gaactctgg  agaactttt  aattcataa  caagccaac  tctccagac  2400
tgt  2403



<210> 5124
<211> 774
<212> PRT
<213> Homo sapiens
<308> BAB14219
<400> 5124

Met Asp Ser Glu Ile Gln Lys Gln Phe Glu Glu Leu Tyr Ser Leu Leu 
  1               5                  10                  15
Glu Asp Pro Tyr Pro Met Val Arg Ser Thr Gly Ile Leu Gly Val Cys 
             20                  25                  30
Lys Ile Thr Ser Lys Tyr Trp Glu Met Met Pro Pro Thr Ile Leu Ile 
         35                  40                  45
Asp Leu Leu Lys Lys Val Thr Gly Glu Leu Ala Phe Asp Thr Ser Ser 
     50                  55                  60
Ala Asp Val Arg Cys Ser Val Phe Lys Cys Leu Pro Met Ile Leu Asp 
 65                  70                  75                  80
Asn Lys Leu Ser His Pro Leu Leu Glu Gln Leu Leu Pro Ala Leu Arg 
                 85                  90                  95
Tyr Ser Leu His Asp Asn Ser Glu Lys Val Arg Val Ala Phe Val Asp 
             100                105                110
Met Leu Leu Lys Ile Lys Ala Val Arg Ala Ala Lys Phe Trp Lys Ile 
         115                120                125
Cys Pro Met Glu His Ile Leu Val Arg Leu Glu Thr Asp Ser Arg Pro 
     130                135                140
Val Ser Arg Arg Leu Val Ser Leu Ile Phe Asn Ser Phe Leu Pro Val 
 145                150                155                160
Asn Gln Pro Glu Glu Val Trp Cys Glu Arg Cys Val Thr Leu Val Gln 
                 165                170                175
Met Asn His Ala Ala Ala Arg Arg Phe Tyr Gln Tyr Ala His Glu His 
             180                185                190
Thr Ala Cys Thr Asn Ile Ala Lys Leu Ile His Val Ile Arg His Cys 
         195                200                205
Leu Asn Ala Cys Ile Gln Arg Ala Val Arg Glu Pro Pro Glu Asp Glu 
     210                215                220
Glu Glu Glu Asp Gly Arg Glu Lys Glu Asn Val Thr Val Leu Asp Lys 
 225                230                235                240
Thr Leu Ser Val Asn Asp Val Ala Cys Met Ala Gly Leu Leu Glu Ile 
                 245                250                255
Ile Val Ile Leu Trp Lys Ser Ile Asp Arg Ser Met Glu Asn Asn Lys 
             260                265                270
Glu Ala Lys Leu Tyr Thr Ile Asn Lys Phe Ala Ser Val Leu Pro Glu 
         275                280                285
Tyr Leu Lys Val Phe Lys Asp Asp Arg Cys Lys Ile Pro Leu Phe Met 
     290                295                300
Leu Met Ser Phe Met Pro Ala Ser Ala Val Pro Pro Phe Ser Cys Gly 
 305                310                315                320
Val Ile Ser Thr Leu Arg Ser Arg Glu Glu Gly Ala Val Asp Lys Ser 
                 325                330                335
Tyr Cys Thr Leu Leu Asp Cys Leu Cys Ser Trp Gly Gln Val Gly His 
             340                345                350
Ile Leu Glu Leu Val Asp Asn Trp Leu Pro Thr Glu His Ala Gln Ala 
         355                360                365
Lys Ser Asn Thr Ala Ser Lys Gly Arg Val Gln Ile His Asp Thr Arg 
     370                375                380
Pro Val Lys Pro Glu Leu Ala Leu Val Tyr Ile Glu Tyr Leu Leu Thr 
 385                390                395                400
His Pro Lys Asn Arg Glu Cys Leu Leu Ser Ala Pro Arg Lys Lys Leu 
                 405                410                415
Asn His Leu Leu Lys Ala Leu Glu Thr Ser Lys Ala Asp Leu Glu Ser 
             420                425                430
Leu Leu Gln Thr Pro Gly Gly Lys Pro Arg Gly Phe Ser Glu Ala Ala 
         435                440                445
Ala Pro Arg Ala Phe Gly Leu His Cys Arg Leu Ser Ile His Leu Gln 
     450                455                460
His Lys Phe Cys Ser Glu Gly Lys Val Tyr Leu Ser Met Leu Glu Asp 
 465                470                475                480
Thr Gly Phe Trp Leu Glu Ser Lys Ile Leu Ser Phe Ile Gln Asp Gln 
                 485                490                495
Glu Glu Asp Tyr Leu Lys Leu His Arg Val Ile Tyr Gln Gln Ile Ile 
             500                505                510
Gln Thr Tyr Leu Thr Val Cys Lys Asp Val Val Met Val Gly Leu Gly 
         515                520                525
Asp His Gln Phe Gln Met Gln Leu Leu Gln Arg Ser Leu Gly Ile Met 
     530                535                540
Gln Thr Val Lys Gly Phe Phe Tyr Val Ser Leu Leu Leu Asp Ile Leu 
 545                550                555                560
Lys Glu Ile Thr Gly Ser Ser Leu Ile Gln Lys Thr Asp Ser Asp Glu 
                 565                570                575
Glu Val Ala Met Leu Leu Asp Thr Val Gln Lys Val Phe Gln Lys Met 
             580                585                590
Leu Glu Cys Ile Ala Arg Ser Phe Arg Lys Gln Pro Glu Glu Gly Leu 
         595                600                605
Arg Leu Leu Tyr Ser Val Gln Arg Pro Leu His Glu Phe Ile Thr Ala 
     610                615                620
Val Gln Ser Arg His Thr Asp Thr Pro Val His Arg Gly Val Leu Ser 
 625                630                635                640
Thr Leu Ile Ala Gly Pro Val Val Glu Ile Ser His Gln Leu Arg Lys 
                 645                650                655
Val Ser Asp Val Glu Glu Leu Thr Pro Pro Glu His Leu Ser Asp Leu 
             660                665                670
Pro Pro Phe Ser Arg Cys Leu Ile Gly Ile Ile Ile Lys Ser Ser Asn 
         675                680                685
Val Val Arg Ser Phe Leu Asp Glu Leu Lys Ala Cys Val Ala Ser Asn 
     690                695                700
Asp Ile Glu Gly Ile Val Cys Leu Thr Ala Ala Val His Ile Ile Leu 
 705                710                715                720
Val Ile Asn Ala Gly Lys His Lys Ser Ser Lys Val Arg Glu Val Ala 
                 725                730                735
Ala Thr Val His Arg Lys Leu Lys Thr Phe Met Glu Ile Thr Leu Glu 
             740                745                750
Glu Asp Ser Ile Glu Arg Phe Leu Tyr Glu Ser Ser Ser Arg Thr Leu 
         755                760                765
Gly Glu Leu Leu Asn Ser 
     770



<210> 5125
<211> 453
<212> DNA
<213> Rattus norvegicus
<308> AA874791
<400> 5125

ttttttttt  tttttttgg  gtgtttcca  aagagaaat  taatctaat  tacatattt  60
taggtacat  gataaccaa  aggtggcca  tgaaaaggt  aaaagttca  ttagctcct  120
gtatctagc  ggcccagga  tgcaaaata  aaagatcca  gttccttat  ctctacaca  180
aacgcattt  ttaaaaaag  gaaagatct  gggagctat  catagaaag  aacagtgaa  240
agggggagg  tggcagggg  gggggagga  agtcccacc  tcactctac  ctcccagcc  300
tggagcccc  gaggctctg  catggcagg  ggcaactgt  agctttgag  tcttccaag  360
taggaaggc  cctttgggg  ggggaaggg  cacccatca  gaatttccg  ggcattgtg  420
gctcactgg  agctcccaa  ccctatggg  tac  453



<210> 5126
<211> 955
<212> PRT
<213> Rattus norvegicus
<308> NP_035847
<400> 5126

Met Glu Gly Leu Leu Ala Gly Gly Leu Ala Ala Pro Asp His Pro Arg 
  1               5                  10                  15
Gly Pro Ala Pro Arg Glu Asp Ile Glu Ser Gly Ala Glu Ala Ala Glu 
             20                  25                  30
Gly Glu Gly Asp Ile Phe Pro Ser Ser His Tyr Leu Pro Ile Thr Lys 
         35                  40                  45
Glu Gly Pro Arg Asp Ile Leu Asp Gly Arg Ser Gly Ile Ser Val Ala 
     50                  55                  60
Asn Phe Asp Pro Gly Thr Phe Ser Leu Met Arg Cys Asp Phe Cys Gly 
 65                  70                  75                  80
Ala Gly Phe Asp Thr Arg Ala Gly Leu Ser Ser His Ala Arg Ala His 
                 85                  90                  95
Leu Arg Asp Phe Gly Ile Thr Asn Trp Glu Leu Thr Ile Ser Pro Ile 
             100                105                110
Asn Ile Leu Gln Glu Leu Leu Ala Thr Ser Ala Ala Glu Leu Pro Pro 
         115                120                125
Ser Pro Leu Gly Arg Glu Pro Gly Gly Pro Pro Gly Ser Phe Leu Thr 
     130                135                140
Ser Arg Arg Pro Arg Leu Pro Leu Thr Met Pro Phe Pro Pro Thr Trp 
 145                150                155                160
Ala Glu Asp Pro Gly Pro Ile Tyr Gly Asp Ala Gln Ser Leu Thr Thr 
                 165                170                175
Cys Glu Val Cys Gly Ala Cys Phe Glu Thr Arg Lys Gly Leu Ser Ser 
             180                185                190
His Ala Arg Ser His Leu Arg Gln Leu Gly Val Ala Glu Ser Glu Ser 
         195                200                205
Ser Gly Ala Pro Ile Asp Leu Leu Tyr Glu Leu Val Lys Gln Lys Gly 
     210                215                220
Leu Pro Asp Ala Pro Leu Gly Leu Thr Pro Ser Leu Thr Lys Lys Ser 
 225                230                235                240
Asn Ser Pro Lys Glu Phe Leu Ala Gly Ala Ala Arg Pro Gly Leu Leu 
                 245                250                255
Thr Leu Ala Lys Pro Met Asp Ala Pro Ala Val Asn Lys Ala Ile Lys 
             260                265                270
Ser Pro Pro Gly Phe Ser Ala Lys Gly Leu Thr His Pro Ser Ser Ser 
         275                280                285
Pro Leu Leu Lys Lys Ala Pro Leu Thr Leu Ala Gly Ser Pro Thr Pro 
     290                295                300
Lys Asn Pro Glu Asp Lys Ser Pro Gln Leu Ser Leu Ser Pro Arg Pro 
 305                310                315                320
Thr Ser Pro Arg Ala Gln Cys Pro Gln Ser Glu Asp Glu Gly Pro Leu 
                 325                330                335
Asn Leu Thr Ser Gly Pro Glu Pro Thr Arg Asp Ile Arg Cys Glu Phe 
             340                345                350
Cys Gly Glu Phe Phe Glu Asn Arg Lys Gly Leu Ser Ser His Ala Arg 
         355                360                365
Ser His Leu Arg Gln Met Gly Val Thr Glu Trp Tyr Val Asn Gly Ser 
     370                375                380
Pro Ile Asp Thr Leu Arg Glu Ile Leu Lys Arg Arg Thr Gln Ser Arg 
 385                390                395                400
Pro Gly Gly His Leu His Pro Pro Gly Pro Ser Pro Lys Ala Leu Ala 
                 405                410                415
Lys Val Leu Ser Thr Gly Gly Pro Gly Ser Ser Leu Glu Ala Arg Ser 
             420                425                430
Pro Ser Asp Leu His Ile Ser Pro Leu Thr Lys Lys Leu Pro Pro Pro 
         435                440                445
Pro Gly Ser Pro Leu Gly His Ser Pro Thr Ala Ser Pro Pro Pro Thr 
     450                455                460
Ala Arg Lys Met Phe Ser Gly Leu Ala Thr Pro Ser Leu Pro Lys Lys 
 465                470                475                480
Leu Lys Pro Glu His Met Arg Val Glu Ile Lys Arg Glu Met Leu Pro 
                 485                490                495
Gly Thr Leu His Gly Glu Pro His Pro Ser Glu Gly Pro Trp Gly Thr 
             500                505                510
Pro Arg Glu Asp Met Ala Pro Leu Asn Leu Ser Arg Ala Glu Pro Val 
         515                520                525
Arg Asp Ile Arg Cys Glu Phe Cys Gly Glu Phe Phe Glu Asn Arg Lys 
     530                535                540
Gly Leu Ser Ser His Ala Arg Ser His Leu Arg Gln Met Gly Val Thr 
 545                550                555                560
Glu Trp Ser Val Asn Gly Ser Pro Ile Asp Thr Leu Arg Glu Ile Leu 
                 565                570                575
Lys Lys Lys Ser Lys Leu Cys Leu Ile Lys Lys Glu Pro Pro Ala Gly 
             580                585                590
Asp Leu Ala Pro Ala Leu Thr Glu Asp Gly Ser Pro Thr Ala Ala Pro 
         595                600                605
Gly Ala Leu His Ser Pro Leu Pro Leu Ser Pro Leu Ala Ser Arg Pro 
     610                615                620
Gly Lys Pro Gly Ala Gly Pro Thr Gln Val Pro Arg Glu Leu Ser Leu 
 625                630                635                640
Ser Pro Ile Thr Gly Ser Lys Pro Ser Ala Ala Ser Tyr Leu Gly Pro 
                 645                650                655
Val Ala Thr Lys Arg Pro Leu Gln Glu Asp Arg Phe Leu Pro Ala Glu 
             660                665                670
Val Lys Ala Lys Thr Tyr Ile Gln Thr Glu Leu Pro Phe Lys Ala Lys 
         675                680                685
Thr Leu His Glu Lys Thr Ser His Ser Ser Thr Glu Ala Cys Cys Glu 
     690                695                700
Leu Cys Gly Leu Tyr Phe Glu Asn Arg Lys Ala Leu Ala Ser His Ala 
 705                710                715                720
Arg Ala His Leu Arg Gln Phe Gly Val Thr Glu Trp Cys Val Asn Gly 
                 725                730                735
Ser Pro Ile Glu Thr Leu Ser Glu Trp Ile Lys His Arg Pro Gln Lys 
             740                745                750
Val Gly Ala Tyr Arg Ser Tyr Ile Gln Gly Gly Arg Pro Phe Thr Lys 
         755                760                765
Lys Phe Arg Ser Ala Gly His Gly Arg Asp Ser Asp Lys Arg Pro Pro 
     770                775                780
Leu Gly Leu Ala Pro Gly Gly Leu Ser Leu Val Gly Arg Ser Ala Gly 
 785                790                795                800
Gly Glu Pro Gly Leu Glu Ala Gly Arg Ala Ala Asp Ser Gly Glu Arg 
                 805                810                815
Pro Leu Ala Thr Ser Pro Pro Gly Thr Val Lys Ser Glu Glu His Gln 
             820                825                830
Arg Gln Asn Ile Asn Lys Phe Glu Arg Arg Gln Ala Arg Pro Ser Asp 
         835                840                845
Ala Ser Ala Ala Arg Gly Gly Glu Glu Val Asn Asp Leu Gln Gln Lys 
     850                855                860
Leu Glu Glu Val Arg Gln Pro Pro Pro Arg Val Arg Pro Val Pro Ser 
 865                870                875                880
Leu Val Pro Arg Pro Pro Gln Thr Ser Leu Val Lys Phe Val Gly Asn 
                 885                890                895
Ile Tyr Thr Leu Lys Cys Arg Phe Cys Glu Val Glu Phe Gln Gly Pro 
             900                905                910
Leu Ser Ile Gln Glu Glu Trp Val Arg His Leu Gln Arg His Ile Leu 
         915                920                925
Glu Met Asn Phe Ser Lys Ala Asp Pro Pro Pro Glu Glu Pro Gln Ala 
     930                935                940
Pro Gln Ala Gln Thr Ala Ala Val Glu Ala Pro 
 945                950                955



<210> 5127
<211> 2058
<212> DNA
<213> Homo sapiens
<308> AL390184
<400> 5127

ggaggggag  cagggcccg  ggctggccg  gcagccgac  gtggtgagc  gcctctggc  60
gccagcccg  caggcaccg  gaaggctga  gagcaccag  ggcagaaca  caacaaatt  120
gaacgccga  aagcccgcc  tccagatgc  tccgcagcc  ggggaggcg  ggacaccaa  180
gacctacag  agaagctgg  ggaggtgcg  caaccccca  cccgagtcc  gccagtccc  240
tccctggtg  cccggcccc  ccagacatc  cttgtcaag  tcgtgggca  catctacac  300
ctcaaatgc  ggttctgtg  ggtggaatt  cagggcccc  tctccatcc  ggaagagtg  360
gtgcggcac  tacagcggc  catcctgga  atgaacttc  ccaaagcgg  ccccccacc  420
gaggagtcc  aggccccgc  ggcacagac  gcggcggca  aggctccct  acacaaaag  480
attccagat  ccctctcgt  ccacctctg  ctcctcttc  tcctcctct  tgtccttgt  540
cctcttcct  tttctttcc  tttccaaag  agcaagcca  aacctcaaa  cggcgcccc  600
tgggggccg  gcacactac  gccagggcg  cgggagcca  ctagctgcc  ttcccccag  660
ccgaggact  tggggccac  gggtgtctt  cttcagccc  tgcccacct  gtccagcag  720
ggcagcagc  aggtctctg  tggcagccg  tctggtcac  ggggaggac  gcactcccc  780
gtctagcag  caggcaggg  gatgtctgc  atccgtggc  atttgcaaa  accccaaag  840
cccctgttc  ggttccctc  ctcccccat  aatatcctc  cacacacat  tacatgcga  900
cacacacaa  acgcacctc  tgagacccg  gacctgccc  ggaccccca  ttcctgggt  960
gaacgacca  atcatgcca  ggtgcttgc  caggggaag  cacgctccc  ctgtggggc  1020
tgctggggc  tgggagccc  ccactgagc  cacaatgcc  cggaaatcc  tgttggctg  1080
ccccgagag  ggccttccc  gctgggaag  gctcagagc  gacagctgc  tcctgccat  1140
tcaaggccc  ccaaagagc  tcaggggct  tggggccct  gagggtggg  ttggggggt  1200
ggactctcc  cccccactc  tgctccctc  cccttttca  tgttgcttt  tatgtatag  1260
tccctagac  tttcacttt  ttaaaaacg  gttttgtgt  gagaataag  aacgtggat  1320
tttttattt  gcaatcctg  gccagctag  agccaggag  tgattgacc  tttaacttt  1380
ttcagtggc  acattttgg  tatcgatgt  cctagaagt  tgtaaatta  attaaattt  1440
tcttctgga  acaccctgg  gcaggcggc  agcgtgtgt  tttctgtca  gtggacagg  1500
tggcattgg  tggcagccg  ggctgggat  ggggcctcc  ctgtccaga  cgccatgga  1560
gccctgggt  ttccagttg  ccgccaagc  gaccagacg  agctgggga  gagcccaag  1620
tcccagctg  tggctcttt  ggccatggc  gggaggggg  ctctggctg  ctggcaaag  1680
ggctccagt  agcagatga  ccagggttc  gggcagcct  tctgggaag  gagccagga  1740
caagaagca  ttgaggcta  aggagctta  caaaggcag  agctaccag  gagggtgtc  1800
gggacccgt  gggagcatt  gggtggggg  cagtggggt  gtagagagc  ggaactcac  1860
tgcttttaa  acatgtgac  tctagtgag  cacatgcac  cctgaccca  ggaacatgc  1920
gggaaaaga  gagccactg  ctcctttgc  atgttattt  ttttctcgc  ctgcaaatg  1980
ttattgaac  tttctgaga  tttaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2040
aaaaaaaaa  aaaaaaaa  2058



<210> 5129
<211> 120
<212> PRT
<213> Rattus norvegicus
<308> AAF75130
<400> 5129

Met Glu Gln Pro Leu Gln Asn Gly Gln Glu Asp Arg Pro Val Gly Gly 
  1               5                  10                  15
Gly Glu Gly His Gln Pro Ala Ala Asn Asn Asn Asn His Asn His Asn 
             20                  25                  30
His Asn His Asn His Asn His Asn His Asn His His Arg Arg Gly Gln 
         35                  40                  45
Ala Arg Arg Leu Ala Pro Asn Phe Arg Trp Ala Ile Pro Asn Arg Gln 
     50                  55                  60
Met Asn Asp Gly Leu Gly Gly Asp Gly Asp Asp Met Glu Met Phe Met 
 65                  70                  75                  80
Glu Glu Met Arg Glu Ile Arg Arg Lys Leu Arg Glu Leu Gln Leu Arg 
                 85                  90                  95
Asn Cys Leu Arg Ile Leu Met Gly Glu Leu Ser Asn His His Asp His 
             100                105                110
His Asp Glu Phe Cys Leu Met Pro 
         115                120



<210> 5130
<211> 891
<212> DNA
<213> Homo sapiens
<308> NM_014380
<400> 5130

accccatcc  ccactccta  accggtcct  cattttggt  cctgcaaag  tctgggaaa  600
aatcccggg  aacgaaaaa  ggtgggttt  ggggaaggg  ggtaagggg  gaaagctgg  660
gggaggggc  ttaattgga  gccccgtag  ggacgcgcg  aacttctaa  gtgggaaaa  720
acgaaatta  aaaatcctt  gatatcagg  ctctgaatc  tgctggtca  agcaccaag  780
attcagtct  tctccttgc  tttgtctta  ttgtgttca  agaaaaaca  ccagaaaaa  840
aaaatctca  catggcaaa  attcaccag  aaaacgaag  gatggagca  c  891



<210> 5131
<211> 104
<212> PRT
<213> Homo sapiens
<308> P00001
<400> 5131

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser Gln 
  1               5                  10                  15
Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
             20                  25                  30
His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Pro Gly Tyr Ser Tyr 
         35                  40                  45
Thr Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Thr Leu 
     50                  55                  60
Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
 65                  70                  75                  80
Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile Ala 
                 85                  90                  95
Tyr Leu Lys Lys Ala Thr Asn Glu 
             100



<210> 5133
<211> 120
<212> PRT
<213> Rattus norvegicus
<308> AAF75130
<400> 5133

Met Glu Gln Pro Leu Gln Asn Gly Gln Glu Asp Arg Pro Val Gly Gly 
  1               5                  10                  15
Gly Glu Gly His Gln Pro Ala Ala Asn Asn Asn Asn His Asn His Asn 
             20                  25                  30
His Asn His Asn His Asn His Asn His Asn His His Arg Arg Gly Gln 
         35                  40                  45
Ala Arg Arg Leu Ala Pro Asn Phe Arg Trp Ala Ile Pro Asn Arg Gln 
     50                  55                  60
Met Asn Asp Gly Leu Gly Gly Asp Gly Asp Asp Met Glu Met Phe Met 
 65                  70                  75                  80
Glu Glu Met Arg Glu Ile Arg Arg Lys Leu Arg Glu Leu Gln Leu Arg 
                 85                  90                  95
Asn Cys Leu Arg Ile Leu Met Gly Glu Leu Ser Asn His His Asp His 
             100                105                110
His Asp Glu Phe Cys Leu Met Pro 
         115                120



<210> 5134
<211> 891
<212> DNA
<213> Homo sapiens
<308> NM_014380
<400> 5134

accccatcc  ccactccta  accggtcct  cattttggt  cctgcaaag  tctgggaaa  600
aatcccggg  aacgaaaaa  ggtgggttt  ggggaaggg  ggtaagggg  gaaagctgg  660
gggaggggc  ttaattgga  gccccgtag  ggacgcgcg  aacttctaa  gtgggaaaa  720
acgaaatta  aaaatcctt  gatatcagg  ctctgaatc  tgctggtca  agcaccaag  780
attcagtct  tctccttgc  tttgtctta  ttgtgttca  agaaaaaca  ccagaaaaa  840
aaaatctca  catggcaaa  attcaccag  aaaacgaag  gatggagca  c  891



<210> 5135
<211> 104
<212> PRT
<213> Homo sapiens
<308> P00001
<400> 5135

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser Gln 
  1               5                  10                  15
Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
             20                  25                  30
His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Pro Gly Tyr Ser Tyr 
         35                  40                  45
Thr Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Thr Leu 
     50                  55                  60
Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
 65                  70                  75                  80
Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile Ala 
                 85                  90                  95
Tyr Leu Lys Lys Ala Thr Asn Glu 
             100



<210> 5136
<211> 553
<212> DNA
<213> Rattus norvegicus
<308> AA874802
<400> 5136

ttttttttt  tttttttcc  ttccagttt  attttaaag  tttaaaatt  caaccacag  60
aattttttc  cggcactag  tacacttgt  taaaaagtg  ggtagggta  ccgagtttc  120
tactttatt  aaataagag  acaactgta  agagttttt  tcccagctc  cgaggtgag  180
ctaagtact  gtcttagat  tggatatat  catatacac  catgcacac  atcccgctt  240
tctaaagct  cctagcaaa  tcgaatcca  gggagtata  cccacagtc  actccctgc  300
tctccccct  ctcggctac  tagaaaaga  tcaaaagct  ggaggggtt  taagtggca  360
aagagaaaa  gaaatcagg  cccccaact  accaccatt  gtagggcag  ccagggagt  420
tatcctctt  tcccccaca  ccccccttg  ccaggtaga  ggggtatca  ctgctcatc  480
aaggttctg  aacgctcac  agggacaag  aacctagtt  ctgggtcct  acctaccca  540
aactttgcc  gtt  553



<210> 5137
<211> 193
<212> PRT
<213> Rattus norvegicus
<308> P43278
<400> 5137

Thr Glu Asn Ser Thr Ser Thr Pro Ala Ala Lys Pro Lys Arg Ala Lys 
  1               5                  10                  15
Ala Ala Lys Lys Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile Val 
             20                  25                  30
Ala Ala Ile Gln Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln Ser 
         35                  40                  45
Ile Gln Lys Tyr Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala Asp 
     50                  55                  60
Ser Gln Ile Lys Leu Ser Ile Lys Arg Leu Val Thr Thr Gly Val Leu 
 65                  70                  75                  80
Lys Gln Thr Lys Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala Lys 
                 85                  90                  95
Gly Asp Glu Pro Lys Arg Ser Val Ala Phe Lys Lys Thr Lys Lys Glu 
             100                105                110
Val Lys Lys Val Ala Thr Pro Lys Lys Ala Ala Lys Pro Lys Lys Ala 
         115                120                125
Ala Ser Lys Ala Pro Ser Lys Lys Pro Lys Ala Thr Pro Val Lys Lys 
     130                135                140
Ala Lys Lys Lys Pro Ala Ala Thr Pro Lys Lys Ala Lys Lys Pro Lys 
 145                150                155                160
Ile Val Lys Val Lys Pro Val Lys Ala Ser Lys Pro Lys Lys Ala Lys 
                 165                170                175
Pro Val Lys Pro Lys Ala Lys Ser Ser Ala Lys Arg Ala Ser Lys Lys 
             180                185                190
Lys 
         195



<210> 5138
<211> 2258
<212> DNA
<213> Homo sapiens
<308> NM_005318
<400> 5138

gccctgtcc  caccgcggt  cgcccgccg  cgctaaata  ccggatgcg  cgcccaagc  60
ccagacgcg  agctgggaa  agggaggca  aggaggcag  ggcagaggc  gaggcagag  120
ccggtgccg  gaccaagcg  cagaccggc  gggctgggc  tcgcaaagc  ggctcggcg  180
gctctcccg  cacccgagc  ggggaggaa  agcagcgac  cctcgctcg  atccccggg  240
gccgcactc  agactggcc  ggtagtcag  ggctcagga  cagatcccg  ggcaggctt  300
gctcagcct  cgacgaggg  tggcccttt  gaaggcgcc  tcaacagcc  gaccagaca  360
gccaccatg  ccgagaatt  cacgtccgc  cctgcggcc  agcccaagc  ggccaaggc  420
tccaagaag  ccacagacc  ccccaagta  tcagacatg  tcgtggctg  catccaggc  480
gagaagaac  gcgctggct  ctcgcgcca  tccattcag  agtatatca  gagccacta  540
aaggtgggt  agaacgctg  ctcgcagat  aagttgtcc  tcaagcgcc  ggtcaccac  600
ggtgtcctc  agcagacca  aggggtggg  gcctcgggg  ccttccggc  agccaagag  660
gacgaaccc  agaagtcag  ggccttcaa  aagaccaag  aggaaatca  gaaggtagc  720
acgccaaag  aggcatcca  gcccaagaa  gctgcctcc  aagccccaa  caagaaacc  780
aaagccacc  cggtcaaga  ggccaagaa  aagctggct  ccacgccca  gaaagccaa  840
aaacccaag  ctgtcaaag  caagccggt  aaggcatcc  agcccaaaa  ggccaaacc  900
gtgaaaccc  aagcaaagt  cagtgccaa  agggccggc  agaagaagt  acaatgaag  960
cttttcttg  ggacactcc  tcctgtctc  tattttctg  aaataattt  ctccttttt  1020
ctctcttga  gctcaccac  accttttgc  cccttctgt  ctgacttta  aagagacag  1080
atttggatt  ttcagaaat  acagaataa  tcatttttc  ttaaccagt  gtgcaagga  1140
agcaacaac  aatctaatg  tgagaatgt  cttatattt  gttttgcta  taacctact  1200
acggggtta  ggatttgcg  ggggggctt  tgtgttttg  tggcttgtt  gccatgaag  1260
tagatgtgg  tggggagaa  acacaaggc  gtttgttct  gctagatga  agggaaccc  1320
ggaattgtg  ggttagcag  aatatcttt  gggtgagtg  gttttcctt  agttgggca  1380
ccgttgtga  agtttcaga  cctttggcc  gcaggagag  ggtggtagg  agcagccag  1440
cggcaaagg  aggaggtgg  aaaaaaccg  caccgggct  acttccacc  cccagtggt  1500
agcagtggg  gcccaaacc  agtttcctt  tcatttttg  tagtttgcc  tttcggcct  1560
cctattttc  tagggaagg  gagtggggt  caagtgaca  ctggatggg  gaagccata  1620
tttctccca  tcagctagg  tgtagccat  gggggatct  tgtggcttc  gcaaattct  1680
ttgttaaac  ggagtgaaa  cttcagggg  agggtgggg  gtcagccaa  tgcctcagt  1740
tgccctgtt  aaacttagg  ttttccacg  aatcgatgg  ttgtgtcct  ggaagactt  1800
tcttttcct  tggattttt  ttcctcctg  acaagaggt  tctttgctt  gtttggtgg  1860
gctgcggcc  cttaaaacc  cccgatctc  ttttgagtc  tttattata  gtagttgta  1920
ctgcgggag  gggaggggg  gtgggcggg  agtggatag  aagacttac  gcagtcgat  1980
tgggatttg  taagtagtt  tacagagct  gatctgtgt  catgtgtgt  tttgtgtat  2040
tatacatat  tagggctag  acttagttt  acacccggg  gctgggaga  aaaacctgt  2100
cagttgtct  tctcttatt  ttaataaaa  agaaaaatc  cgcacttgc  cgtcccccc  2160
ccaccccct  ttttaaaca  gtgttactt  tgccgggaa  attttgctg  ctttgtaat  2220
ttaaaactt  aaaataaat  ggaaaaggg  gaaactga  2258



<210> 5139
<211> 193
<212> PRT
<213> Homo sapiens
<308> P07305
<400> 5139

Thr Glu Asn Ser Thr Ser Ala Pro Ala Ala Lys Pro Lys Arg Ala Lys 
  1               5                  10                  15
Ala Ser Lys Lys Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile Val 
             20                  25                  30
Ala Ala Ile Gln Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln Ser 
         35                  40                  45
Ile Gln Lys Tyr Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala Asp 
     50                  55                  60
Ser Gln Ile Lys Leu Ser Ile Lys Arg Leu Val Thr Thr Gly Val Leu 
 65                  70                  75                  80
Lys Gln Thr Lys Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala Lys 
                 85                  90                  95
Ser Asp Glu Pro Lys Lys Ser Val Ala Phe Lys Lys Thr Lys Lys Glu 
             100                105                110
Ile Lys Lys Val Ala Thr Pro Lys Lys Ala Ser Lys Pro Lys Lys Ala 
         115                120                125
Ala Ser Lys Ala Pro Thr Lys Lys Pro Lys Ala Thr Pro Val Lys Lys 
     130                135                140
Ala Lys Lys Lys Leu Ala Ala Thr Pro Lys Lys Ala Lys Lys Pro Lys 
 145                150                155                160
Thr Val Lys Ala Lys Pro Val Lys Ala Ser Lys Pro Lys Lys Ala Lys 
                 165                170                175
Pro Val Lys Pro Lys Ala Lys Ser Ser Ala Lys Arg Ala Gly Lys Lys 
             180                185                190
Lys 
         195



<210> 5140
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AA874803
<400> 5140

ttttttttt  tttttttgg  aacttcaaa  atattttta  tactttctt  ttcatctta  60
aaagaacat  aaacccgca  gcagcactc  tgaatctca  cacttacat  gcagattca  120
agccgtcca  tgcggcctc  actgagggg  agcgtgtgg  aggggcggg  actgaagca  180
tatgtacac  ggagagggt  cagggtcat  ctaactcca  aagaggacc  cgctgtttg  240
atatgcacc  aagggggag  gcgctttct  tgggggcga  gggaacaga  ctacgtggg  300
ctccccatg  cagtaggat  tgtagctct  gctggatgt  atgcattga  tcctgaatt  360
tcccctttt  ctccacaca  ttttctcac  ctgccgggg  cttctgatg  ttcagaagc  420
tcatctacc  aagcagtga  cctttcaga  accctcaga  gttgcgaga  aaagaccca  480
ctcctttaa  gatcgcttg  ctggttggg  taggggaat  agctggggt  ggggtgggg  540
t  541



<210> 5141
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AA874803
<400> 5141

ttttttttt  tttttttgg  aacttcaaa  atattttta  tactttctt  ttcatctta  60
aaagaacat  aaacccgca  gcagcactc  tgaatctca  cacttacat  gcagattca  120
agccgtcca  tgcggcctc  actgagggg  agcgtgtgg  aggggcggg  actgaagca  180
tatgtacac  ggagagggt  cagggtcat  ctaactcca  aagaggacc  cgctgtttg  240
atatgcacc  aagggggag  gcgctttct  tgggggcga  gggaacaga  ctacgtggg  300
ctccccatg  cagtaggat  tgtagctct  gctggatgt  atgcattga  tcctgaatt  360
tcccctttt  ctccacaca  ttttctcac  ctgccgggg  cttctgatg  ttcagaagc  420
tcatctacc  aagcagtga  cctttcaga  accctcaga  gttgcgaga  aaagaccca  480
ctcctttaa  gatcgcttg  ctggttggg  taggggaat  agctggggt  ggggtgggg  540
t  541



<210> 5142
<211> 494
<212> DNA
<213> Rattus norvegicus
<308> AA874827
<400> 5142

ttttttttt  tttttttgc  gatgcaaaa  cttggttca  gtttaatat  ttaaatatc  60
tacagggtt  ctacagtat  accattaaa  tccatgaac  gggaacatt  aaacactgc  120
atgcaatat  aacagacca  agagaagtg  ataccagtg  atattttca  caatttaag  180
atgtatcaa  gaagtaaca  tgtgaataa  agaatgttt  caataattt  taaattaaa  240
gccctcctg  tgttctctt  agggtctta  cggtgagaa  acgatgagg  taccgccaa  300
ggagaactg  cggcctcga  cttgctgtc  ggtgtcctc  cgagtgcat  ggctagtgc  360
gctgaggtc  ggtggacca  gaagatggc  ttcagaagt  agactttta  gtagcagta  420
tgactggga  agctcagct  cttcttgta  ggagtcacg  tgtgagaag  catttgtct  480
agggtgact  atca  494



<210> 5144
<211> 765
<212> PRT
<213> Homo sapiens
<308> Q15398
<400> 5144

Met Lys Thr Ile Leu Gly Asp Gln Arg Lys Gln Met Leu Gln Lys Tyr 
  1               5                  10                  15
Lys Glu Glu Lys Gln Leu Gln Lys Leu Lys Glu Gln Arg Glu Lys Ala 
             20                  25                  30
Lys Arg Gly Ile Phe Lys Val Gly Arg Tyr Arg Pro Asp Met Pro Cys 
         35                  40                  45
Phe Leu Leu Ser Asn Gln Asn Ala Val Lys Ala Glu Pro Lys Lys Ala 
     50                  55                  60
Ile Pro Ser Ser Val Arg Ile Thr Arg Ser Lys Ala Lys Asp Gln Met 
 65                  70                  75                  80
Glu Gln Thr Lys Ile Asp Asn Glu Ser Asp Val Arg Ala Ile Arg Pro 
                 85                  90                  95
Gly Pro Arg Gln Thr Ser Glu Lys Lys Val Ser Asp Lys Glu Lys Lys 
             100                105                110
Val Val Gln Pro Val Met Pro Thr Ser Leu Arg Met Thr Arg Ser Ala 
         115                120                125
Thr Gln Ala Ala Lys Gln Val Pro Arg Thr Val Ser Ser Thr Thr Ala 
     130                135                140
Arg Lys Pro Val Thr Arg Ala Ala Asn Glu Asn Glu Pro Glu Gly Lys 
 145                150                155                160
Val Pro Ser Lys Gly Arg Pro Ala Lys Asn Val Glu Thr Lys Pro Asp 
                 165                170                175
Lys Gly Ile Ser Cys Lys Val Asp Ser Glu Glu Asn Thr Leu Asn Ser 
             180                185                190
Gln Thr Asn Ala Thr Ser Gly Met Asn Pro Asp Gly Val Leu Ser Lys 
         195                200                205
Met Glu Asn Leu Pro Glu Ile Asn Thr Ala Lys Ile Lys Gly Lys Asn 
     210                215                220
Ser Phe Ala Pro Lys Asp Phe Met Phe Gln Pro Leu Asp Gly Leu Lys 
 225                230                235                240
Thr Tyr Gln Val Thr Pro Met Thr Pro Arg Ser Ala Asn Ala Phe Leu 
                 245                250                255
Thr Pro Ser Tyr Thr Trp Thr Pro Leu Lys Thr Glu Val Asp Glu Ser 
             260                265                270
Gln Ala Thr Lys Glu Ile Leu Ala Gln Lys Cys Lys Thr Tyr Ser Thr 
         275                280                285
Lys Thr Ile Gln Gln Asp Ser Asn Lys Leu Pro Cys Pro Leu Gly Pro 
     290                295                300
Leu Thr Val Trp His Glu Glu His Val Leu Asn Lys Asn Glu Ala Thr 
 305                310                315                320
Thr Lys Asn Leu Asn Gly Leu Pro Ile Lys Glu Val Pro Ser Leu Glu 
                 325                330                335
Arg Asn Glu Gly Arg Ile Ala Gln Pro His His Gly Val Pro Tyr Phe 
             340                345                350
Arg Asn Ile Leu Gln Ser Glu Thr Glu Lys Leu Thr Ser His Cys Phe 
         355                360                365
Glu Trp Asp Arg Lys Leu Glu Leu Asp Ile Pro Asp Asp Ala Lys Asp 
     370                375                380
Leu Ile Arg Thr Ala Val Gly Gln Thr Arg Leu Leu Met Lys Glu Arg 
 385                390                395                400
Phe Lys Gln Phe Glu Gly Leu Val Asp Asp Cys Glu Tyr Lys Arg Gly 
                 405                410                415
Ile Lys Glu Thr Thr Cys Thr Asp Leu Asp Gly Phe Trp Asp Met Val 
             420                425                430
Ser Phe Gln Ile Glu Asp Val Ile His Lys Phe Asn Asn Leu Ile Lys 
         435                440                445
Leu Glu Glu Ser Gly Trp Gln Val Asn Asn Asn Met Asn His Asn Met 
     450                455                460
Asn Lys Asn Val Phe Arg Lys Lys Val Val Ser Gly Ile Ala Ser Lys 
 465                470                475                480
Pro Lys Gln Asp Asp Ala Gly Arg Ile Ala Ala Arg Asn Arg Leu Ala 
                 485                490                495
Ala Ile Lys Asn Ala Met Arg Glu Arg Ile Arg Gln Glu Glu Cys Ala 
             500                505                510
Glu Thr Ala Val Ser Val Ile Pro Lys Glu Val Asp Lys Ile Val Phe 
         515                520                525
Asp Ala Gly Phe Phe Arg Val Glu Ser Pro Val Lys Leu Phe Ser Gly 
     530                535                540
Leu Ser Val Ser Ser Glu Gly Pro Ser Gln Arg Leu Gly Thr Pro Lys 
 545                550                555                560
Ser Val Asn Lys Ala Val Ser Gln Ser Arg Asn Glu Met Gly Ile Pro 
                 565                570                575
Gln Gln Thr Thr Ser Pro Glu Asn Ala Gly Pro Gln Asn Thr Lys Ser 
             580                585                590
Glu His Val Lys Lys Thr Leu Phe Leu Ser Ile Pro Glu Ser Arg Ser 
         595                600                605
Ser Ile Glu Asp Ala Gln Cys Pro Gly Leu Pro Asp Leu Ile Glu Glu 
     610                615                620
Asn His Val Val Asn Lys Thr Asp Leu Lys Val Asp Cys Leu Ser Ser 
 625                630                635                640
Glu Arg Met Ser Leu Pro Leu Leu Ala Gly Gly Val Ala Asp Asp Ile 
                 645                650                655
Asn Thr Asn Lys Lys Glu Gly Ile Ser Asp Val Val Glu Gly Met Glu 
             660                665                670
Leu Asn Ser Ser Ile Thr Ser Gln Asp Val Leu Met Ser Ser Pro Glu 
         675                680                685
Lys Asn Thr Ala Ser Gln Asn Ser Ile Leu Glu Glu Gly Glu Thr Lys 
     690                695                700
Ile Ser Gln Ser Glu Leu Phe Asp Asn Lys Ser Leu Thr Thr Glu Cys 
 705                710                715                720
His Leu Leu Asp Ser Pro Gly Leu Asn Cys Ser Asn Pro Phe Thr Gln 
                 725                730                735
Leu Glu Arg Arg His Gln Glu His Ala Arg His Ile Ser Phe Gly Gly 
             740                745                750
Asn Leu Ile Thr Phe Ser Pro Leu Gln Pro Gly Glu Phe 
         755                760                765



<210> 5145
<211> 585
<212> DNA
<213> Rattus norvegicus
<308> AA874873
<400> 5145

ttttttttt  tttttttca  ttttgccaa  tttattgaa  caataaaat  cctactaat  60
acaatgaaa  aaattctgc  ggtataaac  tgatacagt  taacaaaac  cattgttct  120
tacctataa  tagattttc  aaatgtcat  gaaagtgca  ttatgaatt  ttaacatgt  180
aatacacag  tcctttatt  caggtgtgt  tgtcttgat  cattaacag  tccttcttt  240
tctgttcaa  taatattac  catccctcg  aaaacaaaa  gacagccgc  gaacgagga  300
caacgcttc  ttctggttt  caggagctg  gccaagcgg  aaggccagg  ttcccaggt  360
acctaacag  gttctcatc  cattcacct  gaccagact  tgcgtgtgc  cgttcaatt  420
atagaaaga  gccgccagg  ggcctggga  ttgcttcca  tgttcatct  gctttgggt  480
aaaagagta  atgtgaaga  gaaggaaaa  tcctacttc  tctctcgca  agacatcca  540
atgcaaagg  aatgtgtgc  ctagatgta  atcaccatc  ttggt  585



<210> 5146
<211> 28
<212> PRT
<213> Rattus norvegicus
<308> NP_084537
<400> 5146

Met Ala Leu Pro Leu Gly Ser Ala Pro Ala Asn Leu Lys Glu Thr Phe 
  1               5                  10                  15
Leu Ile Met Glu Glu Leu Asp Val Ala Phe Asn Leu 
             20                  25



<210> 5147
<211> 189
<212> DNA
<213> Homo sapiens
<308> AI497723
<400> 5147

ggtgttcag  tttgccaat  ttattgaac  aataaaatt  ctactaata  caatgaaat  60
aatttctgc  agtataaat  tgatacagt  taacaaaac  cattgttct  tacctataa  120
tagattttc  aaatgtcat  aaaagtgca  ttatgaatt  ttaacatgt  aataccaca  180
ttcctttat  189



<210> 5148
<211> 585
<212> DNA
<213> Rattus norvegicus
<308> AA874873
<400> 5148

ttttttttt  tttttttca  ttttgccaa  tttattgaa  caataaaat  cctactaat  60
acaatgaaa  aaattctgc  ggtataaac  tgatacagt  taacaaaac  cattgttct  120
tacctataa  tagattttc  aaatgtcat  gaaagtgca  ttatgaatt  ttaacatgt  180
aatacacag  tcctttatt  caggtgtgt  tgtcttgat  cattaacag  tccttcttt  240
tctgttcaa  taatattac  catccctcg  aaaacaaaa  gacagccgc  gaacgagga  300
caacgcttc  ttctggttt  caggagctg  gccaagcgg  aaggccagg  ttcccaggt  360
acctaacag  gttctcatc  cattcacct  gaccagact  tgcgtgtgc  cgttcaatt  420
atagaaaga  gccgccagg  ggcctggga  ttgcttcca  tgttcatct  gctttgggt  480
aaaagagta  atgtgaaga  gaaggaaaa  tcctacttc  tctctcgca  agacatcca  540
atgcaaagg  aatgtgtgc  ctagatgta  atcaccatc  ttggt  585



<210> 5149
<211> 189
<212> DNA
<213> Homo sapiens
<308> AI497723
<400> 5149

ggtgttcag  tttgccaat  ttattgaac  aataaaatt  ctactaata  caatgaaat  60
aatttctgc  agtataaat  tgatacagt  taacaaaac  cattgttct  tacctataa  120
tagattttc  aaatgtcat  aaaagtgca  ttatgaatt  ttaacatgt  aataccaca  180
ttcctttat  189



<210> 5150
<211> 585
<212> DNA
<213> Rattus norvegicus
<308> AA874873
<400> 5150

ttttttttt  tttttttca  ttttgccaa  tttattgaa  caataaaat  cctactaat  60
acaatgaaa  aaattctgc  ggtataaac  tgatacagt  taacaaaac  cattgttct  120
tacctataa  tagattttc  aaatgtcat  gaaagtgca  ttatgaatt  ttaacatgt  180
aatacacag  tcctttatt  caggtgtgt  tgtcttgat  cattaacag  tccttcttt  240
tctgttcaa  taatattac  catccctcg  aaaacaaaa  gacagccgc  gaacgagga  300
caacgcttc  ttctggttt  caggagctg  gccaagcgg  aaggccagg  ttcccaggt  360
acctaacag  gttctcatc  cattcacct  gaccagact  tgcgtgtgc  cgttcaatt  420
atagaaaga  gccgccagg  ggcctggga  ttgcttcca  tgttcatct  gctttgggt  480
aaaagagta  atgtgaaga  gaaggaaaa  tcctacttc  tctctcgca  agacatcca  540
atgcaaagg  aatgtgtgc  ctagatgta  atcaccatc  ttggt  585



<210> 5151
<211> 28
<212> PRT
<213> Rattus norvegicus
<308> NP_084537
<400> 5151

Met Ala Leu Pro Leu Gly Ser Ala Pro Ala Asn Leu Lys Glu Thr Phe 
  1               5                  10                  15
Leu Ile Met Glu Glu Leu Asp Val Ala Phe Asn Leu 
             20                  25



<210> 5152
<211> 189
<212> DNA
<213> Homo sapiens
<308> AI497723
<400> 5152

ggtgttcag  tttgccaat  ttattgaac  aataaaatt  ctactaata  caatgaaat  60
aatttctgc  agtataaat  tgatacagt  taacaaaac  cattgttct  tacctataa  120
tagattttc  aaatgtcat  aaaagtgca  ttatgaatt  ttaacatgt  aataccaca  180
ttcctttat  189



<210> 5153
<211> 585
<212> DNA
<213> Rattus norvegicus
<308> AA874873
<400> 5153

ttttttttt  tttttttca  ttttgccaa  tttattgaa  caataaaat  cctactaat  60
acaatgaaa  aaattctgc  ggtataaac  tgatacagt  taacaaaac  cattgttct  120
tacctataa  tagattttc  aaatgtcat  gaaagtgca  ttatgaatt  ttaacatgt  180
aatacacag  tcctttatt  caggtgtgt  tgtcttgat  cattaacag  tccttcttt  240
tctgttcaa  taatattac  catccctcg  aaaacaaaa  gacagccgc  gaacgagga  300
caacgcttc  ttctggttt  caggagctg  gccaagcgg  aaggccagg  ttcccaggt  360
acctaacag  gttctcatc  cattcacct  gaccagact  tgcgtgtgc  cgttcaatt  420
atagaaaga  gccgccagg  ggcctggga  ttgcttcca  tgttcatct  gctttgggt  480
aaaagagta  atgtgaaga  gaaggaaaa  tcctacttc  tctctcgca  agacatcca  540
atgcaaagg  aatgtgtgc  ctagatgta  atcaccatc  ttggt  585



<210> 5154
<211> 189
<212> DNA
<213> Homo sapiens
<308> AI497723
<400> 5154

ggtgttcag  tttgccaat  ttattgaac  aataaaatt  ctactaata  caatgaaat  60
aatttctgc  agtataaat  tgatacagt  taacaaaac  cattgttct  tacctataa  120
tagattttc  aaatgtcat  aaaagtgca  ttatgaatt  ttaacatgt  aataccaca  180
ttcctttat  189



<210> 5155
<211> 530
<212> DNA
<213> Rattus norvegicus
<308> AA874874
<400> 5155

ttttttttt  tttttttca  acaaacaca  agtgtattt  tattacgta  aacgttgca  60
tggtgagca  caattattt  tgtggagag  tcagaaagg  acggcgacc  gttgcctca  120
tcatgattg  agccacgat  ttgcacctt  cttctagtg  gtcctgaag  ctaagtggc  180
gttaagctt  taaatcctg  cggtttcta  tcaatcaca  gaaagagtg  aggatgggc  240
gtactctct  cagaattta  atctttaga  cagttcgaa  gctgtttcc  gagtgcatc  300
gatcaaagg  tttgttaat  tggtcgaag  acagattgc  agtcacaaa  tcgtcaact  360
ttacctttt  ggacatata  tcagacacc  gcttcggga  actctccac  ctcttccag  420
ctccaaagg  agtgccttt  cacgtgcgt  ctgtcacca  ttggaacgg  cgattggag  480
tttcttcac  tgaagcggc  acaccaaca  cagaatggt  accctcgtgc  530



<210> 5156
<211> 373
<212> PRT
<213> Rattus norvegicus
<308> AAC52763
<400> 5156

Ala Asn Gln Val Ile Arg Cys Lys Ala Ala Val Ala Trp Glu Ala Gly 
  1               5                  10                  15
Lys Pro Leu Ser Ile Glu Glu Ile Glu Val Ala Pro Pro Lys Ala His 
             20                  25                  30
Glu Val Arg Ile Lys Ile Leu Ala Thr Ala Val Cys His Thr Asp Ala 
         35                  40                  45
Tyr Thr Leu Ser Gly Arg Asp Pro Glu Gly Cys Phe Pro Val Ile Leu 
     50                  55                  60
Gly His Glu Gly Ala Gly Ile Val Glu Ser Val Gly Glu Gly Val Thr 
 65                  70                  75                  80
Lys Leu Lys Ala Gly Asp Thr Val Ile Pro Leu Tyr Ile Pro Gln Cys 
                 85                  90                  95
Gly Glu Cys Lys Phe Cys Leu Asn Pro Lys Thr Asn Leu Cys Gln Lys 
             100                105                110
Ile Arg Val Thr Gln Gly Lys Gly Leu Met Pro Asp Gly Thr Ser Arg 
         115                120                125
Phe Thr Cys Lys Gly Lys Ser Val Phe His Phe Met Gly Thr Ser Thr 
     130                135                140
Phe Ser Glu Tyr Thr Val Val Ala Asp Ile Ser Val Ala Lys Ile Asp 
 145                150                155                160
Pro Ser Ala Pro Leu Asp Lys Val Cys Leu Leu Gly Cys Gly Ile Ser 
                 165                170                175
Thr Gly Tyr Gly Ala Ala Val Asn Thr Ala Lys Val Glu Pro Gly Ser 
             180                185                190
Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ala Val Ile Met 
         195                200                205
Gly Cys Lys Val Ala Gly Ala Ser Arg Ile Ile Gly Ile Asp Ile Asn 
     210                215                220
Lys Asp Lys Phe Ala Lys Ala Lys Glu Phe Gly Ala Ser Glu Cys Ile 
 225                230                235                240
Ser Pro Gln Asp Phe Ser Lys Ser Ile Gln Glu Val Leu Val Glu Met 
                 245                250                255
Thr Asp Gly Gly Val Asp Tyr Ser Phe Glu Cys Ile Gly Asn Val Lys 
             260                265                270
Val Met Arg Ser Ala Leu Glu Ala Ala His Lys Gly Trp Gly Val Ser 
         275                280                285
Val Val Val Gly Val Ala Ala Ser Gly Glu Glu Ile Ser Thr Arg Pro 
     290                295                300
Phe Gln Leu Val Thr Gly Arg Thr Trp Lys Gly Thr Ala Phe Gly Gly 
 305                310                315                320
Trp Lys Ser Val Glu Ser Val Pro Lys Leu Val Ser Glu Tyr Met Ser 
                 325                330                335
Lys Lys Ile Lys Val Asp Glu Phe Val Thr Gly Asn Leu Ser Phe Asp 
             340                345                350
Gln Ile Asn Gln Ala Phe Asp Leu Met His Ser Gly Asp Ser Ile Arg 
         355                360                365
Thr Val Leu Lys Met 
     370



<210> 5157
<211> 1613
<212> DNA
<213> Homo sapiens
<308> M29872
<400> 5157

gggcatggg  gcggccacc  cggatgtca  ccccccgcg  cgaccagaa  ccgtgaaca  60
ggcgaacga  gttatcaag  gcaaggctg  agttgcttg  gaggctgga  agcctctct  120
catagagga  atagaggtg  cacccccaa  ggctcatga  gttcgaatc  agatcattg  180
cactgcggt  tgccacacc  atgcctata  cctgagtgg  gctgatcct  agggttgtt  240
tccagtgat  ttgggacat  aaggtgctg  aattgtgga  agtgttggt  agggagtta  300
taagctgaa  gcgggtgac  ctgtcatcc  actttacat  ccacagtgt  gagaatgca  360
attttgtct  aatcctaaa  ctaaccttt  ccagaagat  agagtcact  aagggaaag  420
attaatgcc  gatggtacc  gcagattta  ttgcaaagg  aagacaatt  tgcattaca  480
gggaaccag  acattttct  aatacacag  tgtggctga  atctctgtt  ctaaaatag  540
tcctttagc  cctttgtat  aagtctgcc  tctaggttg  ggcatttca  ccggttatg  600
tgctgctgt  aacactgcc  agttggagc  tggctctgt  tgtgccgtc  ttggtctgg  660
aggagtcgg  ttggcagtt  tcatgggct  taaagtggc  ggtgcttcc  ggatcattg  720
tgtggacat  aataaagat  aatttgcaa  ggccaaaga  tttggagcc  ctgaatgta  780
taaccctca  gatttaagt  aacccatcc  ggaagtgct  attgagatg  ccgatggag  840
agtggacta  tcctttgaa  gtattggta  tgtgaaggt  atgagagca  cacttgagg  900
atgtcacaa  ggctggggc  tcagcgtcg  ggttggagt  gctgcttca  gtgaagaaa  960
tgccactcg  ccattccag  tggtaacag  tcgcacatg  aaaggcact  cctttggag  1020
atggaagag  gtagaaagt  tcccaaagt  ggtgtctga  tatatgtcc  aaaagataa  1080
agttgatga  tttgtgact  acaatctgt  ttttgatga  atcaacaaa  cctttgaac  1140
gatgcattc  ggaaagagc  ttcgaactg  tgtaaagat  taattcaaa  gagaaaaat  1200
atgtccatc  tgtcgtgat  tgataggag  agcttaaca  gcagggaga  gcgcctcca  1260
cctcacagc  tcgtagagc  tcacagcta  tccagaaaa  agggttatg  gtgtcattc  1320
tgaatctct  taatcaagg  caaggataa  tcagtcatg  acctgtttt  tggatgctc  1380
tccacataa  taattgcta  ttataagga  atttaacat  ataaaagta  ttctacatt  1440
tgtgaattg  cttgtttat  ctgtcatca  tgtcacggt  tgtctgccc  ttatcttca  1500
tctgcaagg  aaagggaaa  gaagcaggg  agtggtggg  gtctgaaac  tcagaaaca  1560
aacgttgaa  ttttaaggg  ctcagtccc  gttgattaa  gaacagatc  ccg  1613



<210> 5158
<211> 373
<212> PRT
<213> Homo sapiens
<308> P11766
<400> 5158

Ala Asn Glu Val Ile Lys Cys Lys Ala Ala Val Ala Trp Glu Ala Gly 
  1               5                  10                  15
Lys Pro Leu Ser Ile Glu Glu Ile Glu Val Ala Pro Pro Lys Ala His 
             20                  25                  30
Glu Val Arg Ile Lys Ile Ile Ala Thr Ala Val Cys His Thr Asp Ala 
         35                  40                  45
Tyr Thr Leu Ser Gly Ala Asp Pro Glu Gly Cys Phe Pro Val Ile Leu 
     50                  55                  60
Gly His Glu Gly Ala Gly Ile Val Glu Ser Val Gly Glu Gly Val Thr 
 65                  70                  75                  80
Lys Leu Lys Ala Gly Asp Thr Val Ile Pro Leu Tyr Ile Pro Gln Cys 
                 85                  90                  95
Gly Glu Cys Lys Phe Cys Leu Asn Pro Lys Thr Asn Leu Cys Gln Lys 
             100                105                110
Ile Arg Val Thr Gln Gly Lys Gly Leu Met Pro Asp Gly Thr Ser Arg 
         115                120                125
Phe Thr Cys Lys Gly Lys Thr Ile Leu His Tyr Met Gly Thr Ser Thr 
     130                135                140
Phe Ser Glu Tyr Thr Val Val Ala Asp Ile Ser Val Ala Lys Ile Asp 
 145                150                155                160
Pro Leu Ala Pro Leu Asp Lys Val Cys Leu Leu Gly Cys Gly Ile Ser 
                 165                170                175
Thr Gly Tyr Gly Ala Ala Val Asn Thr Ala Lys Leu Glu Pro Gly Ser 
             180                185                190
Val Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ala Val Ile Met 
         195                200                205
Gly Cys Lys Val Ala Gly Ala Ser Arg Ile Ile Gly Val Asp Ile Asn 
     210                215                220
Lys Asp Lys Phe Ala Arg Ala Lys Glu Phe Gly Ala Thr Glu Cys Ile 
 225                230                235                240
Asn Pro Gln Asp Phe Ser Lys Pro Ile Gln Glu Val Leu Ile Glu Met 
                 245                250                255
Thr Asp Gly Gly Val Asp Tyr Ser Phe Glu Cys Ile Gly Asn Val Lys 
             260                265                270
Val Met Arg Ala Ala Leu Glu Ala Cys His Lys Gly Trp Gly Val Ser 
         275                280                285
Val Val Val Gly Val Ala Ala Ser Gly Glu Glu Ile Ala Thr Arg Pro 
     290                295                300
Phe Gln Leu Val Thr Gly Arg Thr Trp Lys Gly Thr Ala Phe Gly Gly 
 305                310                315                320
Trp Lys Ser Val Glu Ser Val Pro Lys Leu Val Ser Glu Tyr Met Ser 
                 325                330                335
Lys Lys Ile Lys Val Asp Glu Phe Val Thr His Asn Leu Ser Phe Asp 
             340                345                350
Glu Ile Asn Lys Ala Phe Glu Leu Met His Ser Gly Lys Ser Ile Arg 
         355                360                365
Thr Val Val Lys Ile 
     370



<210> 5159
<211> 530
<212> DNA
<213> Rattus norvegicus
<308> AA874874
<400> 5159

ttttttttt  tttttttca  acaaacaca  agtgtattt  tattacgta  aacgttgca  60
tggtgagca  caattattt  tgtggagag  tcagaaagg  acggcgacc  gttgcctca  120
tcatgattg  agccacgat  ttgcacctt  cttctagtg  gtcctgaag  ctaagtggc  180
gttaagctt  taaatcctg  cggtttcta  tcaatcaca  gaaagagtg  aggatgggc  240
gtactctct  cagaattta  atctttaga  cagttcgaa  gctgtttcc  gagtgcatc  300
gatcaaagg  tttgttaat  tggtcgaag  acagattgc  agtcacaaa  tcgtcaact  360
ttacctttt  ggacatata  tcagacacc  gcttcggga  actctccac  ctcttccag  420
ctccaaagg  agtgccttt  cacgtgcgt  ctgtcacca  ttggaacgg  cgattggag  480
tttcttcac  tgaagcggc  acaccaaca  cagaatggt  accctcgtgc  530



<210> 5160
<211> 373
<212> PRT
<213> Rattus norvegicus
<308> AAC52763
<400> 5160

Ala Asn Gln Val Ile Arg Cys Lys Ala Ala Val Ala Trp Glu Ala Gly 
  1               5                  10                  15
Lys Pro Leu Ser Ile Glu Glu Ile Glu Val Ala Pro Pro Lys Ala His 
             20                  25                  30
Glu Val Arg Ile Lys Ile Leu Ala Thr Ala Val Cys His Thr Asp Ala 
         35                  40                  45
Tyr Thr Leu Ser Gly Arg Asp Pro Glu Gly Cys Phe Pro Val Ile Leu 
     50                  55                  60
Gly His Glu Gly Ala Gly Ile Val Glu Ser Val Gly Glu Gly Val Thr 
 65                  70                  75                  80
Lys Leu Lys Ala Gly Asp Thr Val Ile Pro Leu Tyr Ile Pro Gln Cys 
                 85                  90                  95
Gly Glu Cys Lys Phe Cys Leu Asn Pro Lys Thr Asn Leu Cys Gln Lys 
             100                105                110
Ile Arg Val Thr Gln Gly Lys Gly Leu Met Pro Asp Gly Thr Ser Arg 
         115                120                125
Phe Thr Cys Lys Gly Lys Ser Val Phe His Phe Met Gly Thr Ser Thr 
     130                135                140
Phe Ser Glu Tyr Thr Val Val Ala Asp Ile Ser Val Ala Lys Ile Asp 
 145                150                155                160
Pro Ser Ala Pro Leu Asp Lys Val Cys Leu Leu Gly Cys Gly Ile Ser 
                 165                170                175
Thr Gly Tyr Gly Ala Ala Val Asn Thr Ala Lys Val Glu Pro Gly Ser 
             180                185                190
Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ala Val Ile Met 
         195                200                205
Gly Cys Lys Val Ala Gly Ala Ser Arg Ile Ile Gly Ile Asp Ile Asn 
     210                215                220
Lys Asp Lys Phe Ala Lys Ala Lys Glu Phe Gly Ala Ser Glu Cys Ile 
 225                230                235                240
Ser Pro Gln Asp Phe Ser Lys Ser Ile Gln Glu Val Leu Val Glu Met 
                 245                250                255
Thr Asp Gly Gly Val Asp Tyr Ser Phe Glu Cys Ile Gly Asn Val Lys 
             260                265                270
Val Met Arg Ser Ala Leu Glu Ala Ala His Lys Gly Trp Gly Val Ser 
         275                280                285
Val Val Val Gly Val Ala Ala Ser Gly Glu Glu Ile Ser Thr Arg Pro 
     290                295                300
Phe Gln Leu Val Thr Gly Arg Thr Trp Lys Gly Thr Ala Phe Gly Gly 
 305                310                315                320
Trp Lys Ser Val Glu Ser Val Pro Lys Leu Val Ser Glu Tyr Met Ser 
                 325                330                335
Lys Lys Ile Lys Val Asp Glu Phe Val Thr Gly Asn Leu Ser Phe Asp 
             340                345                350
Gln Ile Asn Gln Ala Phe Asp Leu Met His Ser Gly Asp Ser Ile Arg 
         355                360                365
Thr Val Leu Lys Met 
     370



<210> 5161
<211> 1613
<212> DNA
<213> Homo sapiens
<308> M29872
<400> 5161

gggcatggg  gcggccacc  cggatgtca  ccccccgcg  cgaccagaa  ccgtgaaca  60
ggcgaacga  gttatcaag  gcaaggctg  agttgcttg  gaggctgga  agcctctct  120
catagagga  atagaggtg  cacccccaa  ggctcatga  gttcgaatc  agatcattg  180
cactgcggt  tgccacacc  atgcctata  cctgagtgg  gctgatcct  agggttgtt  240
tccagtgat  ttgggacat  aaggtgctg  aattgtgga  agtgttggt  agggagtta  300
taagctgaa  gcgggtgac  ctgtcatcc  actttacat  ccacagtgt  gagaatgca  360
attttgtct  aatcctaaa  ctaaccttt  ccagaagat  agagtcact  aagggaaag  420
attaatgcc  gatggtacc  gcagattta  ttgcaaagg  aagacaatt  tgcattaca  480
gggaaccag  acattttct  aatacacag  tgtggctga  atctctgtt  ctaaaatag  540
tcctttagc  cctttgtat  aagtctgcc  tctaggttg  ggcatttca  ccggttatg  600
tgctgctgt  aacactgcc  agttggagc  tggctctgt  tgtgccgtc  ttggtctgg  660
aggagtcgg  ttggcagtt  tcatgggct  taaagtggc  ggtgcttcc  ggatcattg  720
tgtggacat  aataaagat  aatttgcaa  ggccaaaga  tttggagcc  ctgaatgta  780
taaccctca  gatttaagt  aacccatcc  ggaagtgct  attgagatg  ccgatggag  840
agtggacta  tcctttgaa  gtattggta  tgtgaaggt  atgagagca  cacttgagg  900
atgtcacaa  ggctggggc  tcagcgtcg  ggttggagt  gctgcttca  gtgaagaaa  960
tgccactcg  ccattccag  tggtaacag  tcgcacatg  aaaggcact  cctttggag  1020
atggaagag  gtagaaagt  tcccaaagt  ggtgtctga  tatatgtcc  aaaagataa  1080
agttgatga  tttgtgact  acaatctgt  ttttgatga  atcaacaaa  cctttgaac  1140
gatgcattc  ggaaagagc  ttcgaactg  tgtaaagat  taattcaaa  gagaaaaat  1200
atgtccatc  tgtcgtgat  tgataggag  agcttaaca  gcagggaga  gcgcctcca  1260
cctcacagc  tcgtagagc  tcacagcta  tccagaaaa  agggttatg  gtgtcattc  1320
tgaatctct  taatcaagg  caaggataa  tcagtcatg  acctgtttt  tggatgctc  1380
tccacataa  taattgcta  ttataagga  atttaacat  ataaaagta  ttctacatt  1440
tgtgaattg  cttgtttat  ctgtcatca  tgtcacggt  tgtctgccc  ttatcttca  1500
tctgcaagg  aaagggaaa  gaagcaggg  agtggtggg  gtctgaaac  tcagaaaca  1560
aacgttgaa  ttttaaggg  ctcagtccc  gttgattaa  gaacagatc  ccg  1613



<210> 5162
<211> 373
<212> PRT
<213> Homo sapiens
<308> P11766
<400> 5162

Ala Asn Glu Val Ile Lys Cys Lys Ala Ala Val Ala Trp Glu Ala Gly 
  1               5                  10                  15
Lys Pro Leu Ser Ile Glu Glu Ile Glu Val Ala Pro Pro Lys Ala His 
             20                  25                  30
Glu Val Arg Ile Lys Ile Ile Ala Thr Ala Val Cys His Thr Asp Ala 
         35                  40                  45
Tyr Thr Leu Ser Gly Ala Asp Pro Glu Gly Cys Phe Pro Val Ile Leu 
     50                  55                  60
Gly His Glu Gly Ala Gly Ile Val Glu Ser Val Gly Glu Gly Val Thr 
 65                  70                  75                  80
Lys Leu Lys Ala Gly Asp Thr Val Ile Pro Leu Tyr Ile Pro Gln Cys 
                 85                  90                  95
Gly Glu Cys Lys Phe Cys Leu Asn Pro Lys Thr Asn Leu Cys Gln Lys 
             100                105                110
Ile Arg Val Thr Gln Gly Lys Gly Leu Met Pro Asp Gly Thr Ser Arg 
         115                120                125
Phe Thr Cys Lys Gly Lys Thr Ile Leu His Tyr Met Gly Thr Ser Thr 
     130                135                140
Phe Ser Glu Tyr Thr Val Val Ala Asp Ile Ser Val Ala Lys Ile Asp 
 145                150                155                160
Pro Leu Ala Pro Leu Asp Lys Val Cys Leu Leu Gly Cys Gly Ile Ser 
                 165                170                175
Thr Gly Tyr Gly Ala Ala Val Asn Thr Ala Lys Leu Glu Pro Gly Ser 
             180                185                190
Val Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ala Val Ile Met 
         195                200                205
Gly Cys Lys Val Ala Gly Ala Ser Arg Ile Ile Gly Val Asp Ile Asn 
     210                215                220
Lys Asp Lys Phe Ala Arg Ala Lys Glu Phe Gly Ala Thr Glu Cys Ile 
 225                230                235                240
Asn Pro Gln Asp Phe Ser Lys Pro Ile Gln Glu Val Leu Ile Glu Met 
                 245                250                255
Thr Asp Gly Gly Val Asp Tyr Ser Phe Glu Cys Ile Gly Asn Val Lys 
             260                265                270
Val Met Arg Ala Ala Leu Glu Ala Cys His Lys Gly Trp Gly Val Ser 
         275                280                285
Val Val Val Gly Val Ala Ala Ser Gly Glu Glu Ile Ala Thr Arg Pro 
     290                295                300
Phe Gln Leu Val Thr Gly Arg Thr Trp Lys Gly Thr Ala Phe Gly Gly 
 305                310                315                320
Trp Lys Ser Val Glu Ser Val Pro Lys Leu Val Ser Glu Tyr Met Ser 
                 325                330                335
Lys Lys Ile Lys Val Asp Glu Phe Val Thr His Asn Leu Ser Phe Asp 
             340                345                350
Glu Ile Asn Lys Ala Phe Glu Leu Met His Ser Gly Lys Ser Ile Arg 
         355                360                365
Thr Val Val Lys Ile 
     370



<210> 5163
<211> 437
<212> DNA
<213> Rattus norvegicus
<308> AA874897
<400> 5163

ttttttttt  tttttttgg  gagagcacc  ttatttgaa  taacatcac  ggtctctga  60
cacctcttg  agacagaga  tagctcagg  agagcctac  gggcccagg  gatcaggtt  120
cagccttgc  taagcacca  gaactttag  gacggtcac  cctgccagg  agggagaca  180
acccaaggg  ggtcctttc  atcctctga  tgctggggc  aaggccagg  tagaggagc  240
ccaggttat  tgggtcata  gagaccaag  accagtcag  gaggtcttc  gggctgtgg  300
atagttctt  tgtggaacc  gctatgacc  cagcctcaa  gtgtgtgga  acggccgct  360
gcaagccta  ggtataggc  gtttgtaaa  gggacacgg  tttgtgtca  ccatcagat  420
gcagggctc  agagata  437



<210> 5164
<211> 440
<212> PRT
<213> Rattus norvegicus
<308> NP_077794
<400> 5164

Met Lys Leu Val Leu Leu Leu Pro Trp Ala Cys Cys Cys Leu Cys Gly 
  1               5                  10                  15
Ser Ala Leu Ala Thr Gly Phe Leu Tyr Pro Phe Pro Ala Ala Ala Leu 
             20                  25                  30
Gln Gln His Gly Tyr Pro Glu Gln Gly Ala Gly Ser Pro Gly Asn Gly 
         35                  40                  45
Tyr Ser Ser Arg Arg His Trp Cys His His Thr Val Thr Arg Thr Val 
     50                  55                  60
Ser Cys Gln Val Gln Asn Gly Ser Glu Thr Val Val Gln Arg Val Tyr 
 65                  70                  75                  80
Gln Ser Cys Arg Trp Pro Gly Pro Cys Ala Asn Leu Val Ser Tyr Arg 
                 85                  90                  95
Thr Leu Ile Arg Pro Thr Tyr Arg Val Ser Tyr Arg Thr Val Thr Ala 
             100                105                110
Leu Glu Trp Arg Cys Cys Pro Gly Phe Thr Gly Ser Asn Cys Glu Glu 
         115                120                125
Glu Cys Met Asn Cys Thr Arg Leu Ser Asp Met Ser Glu Arg Leu Thr 
     130                135                140
Thr Leu Glu Ala Lys Val Leu Leu Leu Glu Ala Ala Glu Gln Pro Ser 
 145                150                155                160
Gly Pro Asp Asn Asp Leu Pro Pro Pro Gln Ser Thr Pro Pro Thr Trp 
                 165                170                175
Asn Glu Asp Phe Leu Pro Asp Ala Ile Pro Ile Ala His Pro Gly Pro 
             180                185                190
Arg Arg Arg Arg Pro Thr Gly Pro Ala Gly Pro Pro Gly Gln Met Gly 
         195                200                205
Pro Pro Gly Pro Ala Gly Pro Pro Gly Ser Lys Gly Glu Gln Gly Gln 
     210                215                220
Thr Gly Glu Lys Gly Pro Val Gly Pro Pro Gly Leu Leu Gly Pro Pro 
 225                230                235                240
Gly Pro Arg Gly Leu Pro Gly Glu Met Gly Arg Pro Gly Pro Pro Gly 
                 245                250                255
Pro Pro Gly Pro Ala Gly Ser Pro Gly Leu Leu Pro Asn Thr Pro Gln 
             260                265                270
Gly Val Leu Tyr Ser Leu Gln Thr Pro Thr Asp Lys Glu Asn Gly Asp 
         275                280                285
Ser Gln Leu Asn Pro Ala Val Val Asp Thr Val Leu Thr Gly Ile Pro 
     290                295                300
Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro His Gly 
 305                310                315                320
Pro Pro Gly Pro Pro Gly Ala Pro Gly Ser Gln Gly Leu Val Asp Glu 
                 325                330                335
Arg Val Val Ala Arg Pro Ser Gly Glu Pro Ser Val Lys Glu Glu Glu 
             340                345                350
Asp Lys Ala Ser Ala Ala Glu Gly Glu Gly Val Gln Gln Leu Arg Glu 
         355                360                365
Ala Leu Lys Ile Leu Ala Glu Arg Val Leu Ile Leu Glu His Met Ile 
     370                375                380
Gly Val His Asp Pro Leu Ala Ser Pro Glu Gly Gly Ser Gly Gln Asp 
 385                390                395                400
Ala Ala Leu Arg Ala Asn Leu Lys Met Lys Arg Gly Gly Pro Arg Pro 
                 405                410                415
Asp Gly Ile Leu Ala Ala Leu Leu Gly Pro Asp Pro Ala Gln Lys Ser 
             420                425                430
Ala Asp Gln Ala Gly Asp Arg Lys 
         435                440



<210> 5165
<211> 542
<212> DNA
<213> Rattus norvegicus
<308> AA874924
<400> 5165

ttttttttt  tttttttac  gggcagctt  tatttttat  attttattt  tttacatcc  60
aggtgactt  aaagaagtg  tgctaaggg  catataaga  gtaactttg  tgagatgca  120
ttccataag  agagctgtt  tagatgggg  ctcgggact  cttagagtc  tcagaaata  180
acaattttg  aggttttat  acattcatt  ggtctggga  tatctgtcc  tagagccaa  240
atcggcaga  tgacccacg  gaaacttct  tgtagttcc  ctttgtcat  ggtggttct  300
gcagcgagg  gaccttggg  ttccctgag  ctgagtttc  tgtgcattt  cttgcaggc  360
atgctcagg  gcaggtgac  gtggcatta  cacaagcca  agtagcatg  ttttcattg  420
acagttcca  caagagctg  tattctccc  gtggaacat  aagcccagg  ttattgaca  480
ggccggcat  gtatatctg  tctcctttc  ttcttccac  gaaagagaa  ttgggctgg  540
cc  542



<210> 5166
<211> 162
<212> PRT
<213> Rattus norvegicus
<308> NP_034875
<400> 5166

Met Asn Gly Val Ala Ala Ala Leu Leu Val Trp Ile Leu Thr Ser Pro 
  1               5                  10                  15
Ser Ser Ser Asp His Gly Ser Glu Asn Gly Trp Pro Lys His Thr Ala 
             20                  25                  30
Cys Asn Ser Gly Gly Leu Glu Val Val Tyr Gln Ser Cys Asp Pro Leu 
         35                  40                  45
Gln Asp Phe Gly Leu Ser Ile Asp Gln Cys Ser Lys Gln Ile Gln Ser 
     50                  55                  60
Asn Leu Asn Ile Arg Phe Gly Ile Ile Leu Arg Gln Asp Ile Arg Lys 
 65                  70                  75                  80
Leu Phe Leu Asp Ile Thr Leu Met Ala Lys Gly Ser Ser Ile Leu Asn 
                 85                  90                  95
Tyr Ser Tyr Pro Leu Cys Glu Glu Asp Gln Pro Lys Phe Ser Phe Cys 
             100                105                110
Gly Arg Arg Lys Gly Glu Gln Ile Tyr Tyr Ala Gly Pro Val Asn Asn 
         115                120                125
Pro Gly Leu Asp Val Pro Gln Gly Glu Tyr Gln Leu Leu Leu Glu Leu 
     130                135                140
Tyr Asn Glu Asn Arg Ala Thr Val Ala Cys Ala Asn Ala Thr Val Thr 
 145                150                155                160
Ser Ser 
                 165



<210> 5167
<211> 725
<212> DNA
<213> Homo sapiens
<308> AB020499
<400> 5167

gttgcgatc  attacaaga  tttggcttt  ctgttgaaa  gtgttccaa  caattaaaa  60
caaatatca  cattagatt  ggaattatt  tgagagagg  catcaaaga  ctttttctt  120
acctagctc  catgtctca  ggctcatct  ttttgaatt  ctcctatcc  atctgtgag  180
cggctctgc  caagttttc  ttctgtgga  gaaggaaag  agagcagat  tactatgct  240
ggcctgtca  taatcctga  tttactatt  ctcagggag  ataccaggt  ttgctggaa  300
tgtacactg  aaaacggtc  accgtggcc  gtgccaatg  tactatcat  tgctcctga  360
tgtggcctg  agcaaaaat  acagccagc  gcatctcgt  ggacctcca  gctcctctg  420
ctgaaccta  tgtgggagg  gaagcagct  atgacagag  gaggctcta  aaagaagcg  480
ccccaaaga  tgcagctgc  aattttagt  ccaggacca  acatcccca  actccacag  540
tgtaatgaa  tccccgaat  tatctgttt  taaggagcc  cttggcagt  cttaagcag  600
cttgagggt  catcctttt  ctctaattg  tcgcctccc  ccagactca  ctgcttttc  660
actttttag  agtgcttcc  cacagttac  aagaataaa  aaagctggc  accaaaaaa  720
aaaaa  725



<210> 5168
<211> 162
<212> PRT
<213> Homo sapiens
<308> O95711
<400> 5168

Met Lys Gly Phe Thr Ala Thr Leu Phe Leu Trp Thr Leu Ile Phe Pro 
  1               5                  10                  15
Ser Cys Ser Gly Gly Gly Gly Gly Lys Ala Trp Pro Thr His Val Val 
             20                  25                  30
Cys Ser Asp Ser Gly Leu Glu Val Leu Tyr Gln Ser Cys Asp Pro Leu 
         35                  40                  45
Gln Asp Phe Gly Phe Ser Val Glu Lys Cys Ser Lys Gln Leu Lys Ser 
     50                  55                  60
Asn Ile Asn Ile Arg Phe Gly Ile Ile Leu Arg Glu Asp Ile Lys Glu 
 65                  70                  75                  80
Leu Phe Leu Asp Leu Ala Leu Met Ser Gln Gly Ser Ser Val Leu Asn 
                 85                  90                  95
Phe Ser Tyr Pro Ile Cys Glu Ala Ala Leu Pro Lys Phe Ser Phe Cys 
             100                105                110
Gly Arg Arg Lys Gly Glu Gln Ile Tyr Tyr Ala Gly Pro Val Asn Asn 
         115                120                125
Pro Glu Phe Thr Ile Pro Gln Gly Glu Tyr Gln Val Leu Leu Glu Leu 
     130                135                140
Tyr Thr Glu Lys Arg Ser Thr Val Ala Cys Ala Asn Ala Thr Ile Met 
 145                150                155                160
Cys Ser 
                 165



<210> 5169
<211> 494
<212> DNA
<213> Rattus norvegicus
<308> AA874926
<400> 5169

ttttttttt  tttttttaa  ttagcttct  aatcatcat  tggaaagaa  acattctga  60
caacatcat  aaaaacagc  ctgataaag  acggtcact  ctacgtatc  taaagcagg  120
acaagctat  ttacatcca  agaggtatg  tacagtact  tcctacatc  ataatacta  180
aggatacaa  ttaaaaggc  ttatttgag  cttgattct  cttttccag  agagggccc  240
aaggatggt  tgtgacaca  ctttgtaaa  aaacatact  tagacagga  ttcctttca  300
tagtggcac  gttctaagg  ttcattctc  ccatgaatg  cagctaaaa  cgttattaa  360
aaaatgaaa  atccctaaa  caaaaccgt  taaccaccg  attcacatg  agatgacct  420
gtggagaca  gctggacct  accttacca  caagctatc  aatctgtta  gtttaaaca  480
tgagacctc  aagg  494



<210> 5170
<211> 2307
<212> DNA
<213> Homo sapiens
<308> AJ006470
<400> 5170

ggcacgagg  gatggagcc  gggcgccgg  gggccgcgg  gctgctagc  ctgctgtgc  60
tggcctgcg  gctgcgcgc  gggcgcgcc  aatacgaac  ctacagctt  cgcagcttc  120
cacgggacg  gctgatgcc  ctcgagtcg  cctaccggc  cgcgctgga  aagtacagc  180
gcgagcact  ggccgagag  gtgggctac  tggagatca  cctgcggct  caccgcttg  240
tgcgcgaca  cgaggcctt  tgccaccgc  actgcagcg  cgcgccgca  cccgagccc  300
ccgccggcc  cgccagcta  cccgagctg  gcctcttcg  gggcctgct  cgccgcgcg  360
actgcctca  gcgctgcaa  cagggcctg  cagccttcc  ccagtccca  cccagccgc  420
aggtgctgg  ggacttcca  cgccgcgag  cctacaagt  cctgcagtt  gcttacttc  480
aggcaaata  tctccccaa  gccatcgcc  ctgctcaca  ctttctact  aagcatcct  540
atgacgaaa  gatgaagag  aacatggca  attataaga  cctgcctgg  gccgaggac  600
acattaaag  cctggaaac  aagtcatat  aaagcctgt  catccgagc  gtgcgggca  660
acaacggtg  gaactggag  acatccatc  cagacatgg  gctggccct  cccgacttc  720
tcaaagcct  ttacgagtg  ctcgcagcc  gcgagggtt  cagggagat  aaggacttc  780
aggatttct  cctttccat  gcagatcat  atgtagaag  tctggaatg  aaaatacag  840
gtgaagaga  cctcacccc  gttatagga  gctatccgg  tgagaaatt  gtggctacc  900
tgtatcatt  cttgcagtt  gcctattat  agttgaacg  cctgaagaa  gcagccccc  960
gtgcagtca  ctatctgct  tttgatcag  atgacaagg  catgcagca  aacctggtg  1020
attaccagt  ccacaggga  acttggggc  tctcggatg  gcacttcca  cccagacct  1080
aagcagttc  gttctttaa  gtgaccaca  tccagaagg  gctgtatga  tttgctaag  1140
aaaatataa  ggatgatga  gagggagaa  ttgtggaat  tgtggatga  ctcttggaa  1200
tggaggaga  cagctagcc  acagcaacc  aagagactt  ctcttggcg  tcaggaaac  1260
cagattctt  gtccttttc  caacagccc  ggctgttga  acctcagag  cttctcttt  1320
ctctccaaa  tgaaaggga  gcccccgtc  ctctaactg  atgtcatca  gggtgagcc  1380
gcctttcct  tcttcacac  tgccacctc  tgttcacac  tatctttct  acctttttt  1440
tgagatgga  tctcgctct  ttgcccagg  tggagtgca  tggcacgtt  tcagctcac  1500
gcaacctcc  cctcttggg  tcaagcaat  ctgctgcat  agcctcccg  gtacctggg  1560
ttacaggca  gtgccacca  gcccggcta  ttttgtatt  ttaagtaag  gacggggtt  1620
tgccatgtt  gccaggctg  tctcgaact  ttgacttca  atgatccat  tgccttggg  1680
ctcccacag  gctgggatt  caggcgtga  ccaccatgc  cggcctctt  ctcaccttt  1740
cacctgtct  cttatcctc  catctgttt  cacaccttc  tccctgtct  cctcatgtt  1800
acacttgtc  tccccatgt  catagctgc  tttcttacc  ttttggttt  aagggcagt  1860
ttctctggc  tgttttttt  tttttccca  aaaatcagt  ttatttttt  aataagaaa  1920
acattccta  aagatgata  ttgtgaaaa  ctcctttgg  ttatttgct  ttccagatt  1980
tagtctcct  tctccccat  cgggaaaga  kgtggaaga  ataggctaa  tttctccag  2040
ctcacaatg  tcttcactt  gtctgactt  taccaattc  agcacccac  gaaaaacaa  2100
ttgagtaga  agtgtagag  gcagaaatg  ggcttttgc  ccactttgc  tctccaaaa  2160
tacaacggt  ggccgatcn  aattgagga  aatgnttag  tataagtct  cgagttgga  2220
aaggaagaa  gccagagct  tctagtttc  ttcattctt  cagtaaata  ttattgagt  2280
aaaaaaaaa  aaaaaaaaa  aaaaaaa  2307



<210> 5171
<211> 401
<212> PRT
<213> Homo sapiens
<308> O75718
<400> 5171

Met Glu Pro Gly Arg Arg Gly Ala Ala Ala Leu Leu Ala Leu Leu Cys 
  1               5                  10                  15
Val Ala Cys Ala Leu Arg Ala Gly Arg Ala Gln Tyr Glu Arg Tyr Ser 
             20                  25                  30
Phe Arg Ser Phe Pro Arg Asp Glu Leu Met Pro Leu Glu Ser Ala Tyr 
         35                  40                  45
Arg His Ala Leu Asp Lys Tyr Ser Gly Glu His Trp Ala Glu Ser Val 
     50                  55                  60
Gly Tyr Leu Glu Ile Ser Leu Arg Leu His Arg Leu Leu Arg Asp Ser 
 65                  70                  75                  80
Glu Ala Phe Cys His Arg Asn Cys Ser Ala Ala Pro Gln Pro Glu Pro 
                 85                  90                  95
Ala Ala Gly Leu Ala Ser Tyr Pro Glu Leu Arg Leu Phe Gly Gly Leu 
             100                105                110
Leu Arg Arg Ala His Cys Leu Lys Arg Cys Lys Gln Gly Leu Pro Ala 
         115                120                125
Phe Arg Gln Ser Gln Pro Ser Arg Glu Val Leu Ala Asp Phe Gln Arg 
     130                135                140
Arg Glu Pro Tyr Lys Phe Leu Gln Phe Ala Tyr Phe Lys Ala Asn Asn 
 145                150                155                160
Leu Pro Lys Ala Ile Ala Ala Ala His Thr Phe Leu Leu Lys His Pro 
                 165                170                175
Asp Asp Glu Met Met Lys Arg Asn Met Ala Tyr Tyr Lys Ser Leu Pro 
             180                185                190
Gly Ala Glu Asp Tyr Ile Lys Asp Leu Glu Thr Lys Ser Tyr Glu Ser 
         195                200                205
Leu Phe Ile Arg Ala Val Arg Ala Tyr Asn Gly Glu Asn Trp Arg Thr 
     210                215                220
Ser Ile Thr Asp Met Glu Leu Ala Leu Pro Asp Phe Phe Lys Ala Phe 
 225                230                235                240
Tyr Glu Cys Leu Ala Ala Cys Glu Gly Ser Arg Glu Ile Lys Asp Phe 
                 245                250                255
Lys Asp Phe Tyr Leu Ser Ile Ala Asp His Tyr Val Glu Val Leu Glu 
             260                265                270
Cys Lys Ile Gln Cys Glu Glu Asn Leu Thr Pro Val Ile Gly Gly Tyr 
         275                280                285
Pro Val Glu Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala 
     290                295                300
Tyr Tyr Lys Leu Asn Asp Leu Lys Asn Ala Ala Pro Cys Ala Val Ser 
 305                310                315                320
Tyr Leu Leu Phe Asp Gln Asn Asp Lys Val Met Gln Gln Asn Leu Val 
                 325                330                335
Tyr Tyr Gln Tyr His Arg Asp Thr Trp Gly Leu Ser Asp Glu His Phe 
             340                345                350
Gln Pro Arg Pro Glu Ala Val Gln Phe Phe Asn Val Thr Thr Leu Gln 
         355                360                365
Lys Glu Leu Tyr Asp Phe Ala Lys Glu Asn Ile Met Asp Asp Asp Glu 
     370                375                380
Gly Glu Val Val Glu Tyr Val Asp Asp Leu Leu Glu Leu Glu Glu Thr 
 385                390                395                400
Ser 
                 405



<210> 5172
<211> 350
<212> DNA
<213> Rattus norvegicus
<308> AA874934
<400> 5172

ttttttttt  tttttttaa  gaaagaaag  gccaactct  taatacaga  ccttcatta  60
aatgtccca  ccctgcgca  ctgctcttc  aaaggggcg  ccaccaagg  tctctacct  120
cctaagatg  agcagaccc  tttggccac  cattaaata  ttgttccca  gatgggggt  180
ggtgtaagg  cagggcccc  gccaccttc  tcggggaca  ttgtgcatg  ttacgcctt  240
tctgattgt  tcagtggcc  aagcatggc  actgggcat  aataaacat  tcttgagga  300
gtgggctca  tgtgctggc  caggaggag  actgggcgg  gtgcctggca  350



<210> 5173
<211> 405
<212> PRT
<213> Rattus norvegicus
<308> BAA23430
<400> 5173

Met Arg Gly Arg Arg Gly Asp Arg Met Thr Ile Asn Ile Gln Glu His 
  1               5                  10                  15
Met Ala Ile Asn Val Cys Pro Gly Pro Ile Arg Pro Ile Arg Gln Ile 
             20                  25                  30
Ser Asp Tyr Phe Pro Arg Arg Gly Pro Gly Pro Glu Gly Gly Gly Gly 
         35                  40                  45
Gly Gly Gly Thr Gly Cys Gly Glu Ala Pro Ala His Leu Ala Pro Leu 
     50                  55                  60
Ala Leu Ala Pro Pro Ala Ala Leu Leu Gly Ala Thr Thr Pro Asp Asp 
 65                  70                  75                  80
Gly Ala Glu Val Asp Ser Tyr Asp Ser Asp Asp Thr Thr Ala Leu Gly 
                 85                  90                  95
Thr Leu Glu Phe Asp Leu Leu Tyr Asp Gln Ala Ser Cys Met Leu His 
             100                105                110
Cys Arg Ile Leu Arg Ala Lys Gly Leu Lys Pro Met Asp Phe Asn Gly 
         115                120                125
Leu Ala Asp Pro Tyr Val Lys Leu His Leu Leu Pro Gly Ala Cys Lys 
     130                135                140
Ala Asn Lys Leu Lys Thr Lys Thr Gln Arg Asn Thr Leu Asn Pro Val 
 145                150                155                160
Trp Asn Glu Glu Leu Thr Tyr Ser Gly Ile Thr Asp Asp Asp Ile Thr 
                 165                170                175
His Lys Val Leu Arg Ile Ser Val Cys Asp Glu Asp Lys Leu Ser His 
             180                185                190
Asn Glu Phe Ile Gly Glu Ile Arg Val Pro Leu Arg Arg Leu Lys Pro 
         195                200                205
Ser Gln Lys Lys His Phe Asn Ile Cys Leu Glu Arg Gln Val Pro Leu 
     210                215                220
Pro Ser Pro Ser Ser Met Ser Ala Ala Leu Arg Gly Ile Ser Cys Tyr 
 225                230                235                240
Leu Lys Glu Leu Glu Gln Ala Glu Gln Gly Pro Gly Leu Leu Glu Glu 
                 245                250                255
Arg Gly Pro Ile Leu Leu Ser Leu Ser Tyr Ser Ser Arg Arg His Gly 
             260                265                270
Leu Leu Val Gly Ile Val Arg Cys Ala His Leu Ala Ala Met Asp Val 
         275                280                285
Asn Gly Tyr Ser Asp Pro Tyr Val Lys Thr Tyr Leu Arg Pro Asp Val 
     290                295                300
Asp Lys Lys Ser Lys His Lys Thr Cys Val Lys Lys Lys Thr Leu Asn 
 305                310                315                320
Pro Glu Phe Asn Glu Glu Phe Phe Tyr Glu Ile Glu Leu Ser Thr Leu 
                 325                330                335
Ala Thr Lys Thr Leu Glu Val Thr Val Trp Asp Tyr Asp Ile Gly Lys 
             340                345                350
Ser Asn Asp Phe Ile Gly Gly Val Ser Leu Gly Pro Gly Ala Arg Gly 
         355                360                365
Glu Ala Gln Lys His Trp Asn Asp Cys Leu His Gln Pro Asp Thr Ala 
     370                375                380
Leu Glu Arg Trp His Thr Leu Thr Ser Glu Leu Pro Pro Ala Ala Gly 
 385                390                395                400
Ala Tyr Pro Leu Ala 
                 405



<210> 5174
<211> 1621
<212> DNA
<213> Homo sapiens
<308> NM_003586
<400> 5174

tcctgacgg  gctggagct  aggggcagt  cggatgccc  aggaaggct  ctaggaaga  60
gggacccac  gtgacttcc  aaggaagcg  ggttcccag  caggggtgc  gcatgaggg  120
ccgcagggg  gatcgcatg  ccatcaaca  ccaggagca  atggccatc  acgtgtgcc  180
cgggcccat  cggcccatc  gccagatct  tgactactt  ccccgggga  caggacctg  240
agggggcgg  gggagcggc  gggaggccc  cgcccatct  gtccccctg  ctctggccc  300
ccctgcagc  ctccttggg  ccaccacgc  tgaggatgg  gcggaggtg  acagctatg  360
ctcggatga  gccaccgcc  taggcaagc  ggagtttga  cttctctac  accgggcct  420
ctgcactct  cacgtatgc  tcctcaggg  caagggcct  aagcccatg  atttcaatg  480
cctcgccga  ccctacgtc  agctgcact  gctgcctgg  gcctgtaag  ccaataagc  540
aaaaacgaa  actcagagg  acacactga  tcccgtgtg  aatgaggac  tgacttaca  600
cgggatcac  gatgacgac  tcacgcaca  ggtgctcag  atcgccgtc  gtgatgagg  660
caagctgag  cacaatgag  ttattgggg  gatccgcgt  cccctccgc  gcctcaagc  720
ttcgcagaa  aagcatttt  acatctgcc  cgagcgcca  gtcccgctg  cgtccccct  780
ttccatgtc  gcggcgctg  ggggcatct  ctgttatct  aaggacttg  agcaggcgg  840
gcaggggca  gggctgctg  aggagcgtg  ccgcatcct  ctgagtctc  gctacagct  900
gcggcgccg  ggactgctg  taggcatct  gcgctgcgc  catctggct  ccatggacg  960
caacggtta  tcggacccc  acgtcaaga  gtacctgag  cccgatgtg  acaagaaat  1020
caagcataa  acgtgtgtg  agaagaaga  tctcaaccc  gaatttaac  aggagtttt  1080
ctacgagat  gagctctcc  ctctggcca  caagaccct  gaagtcacc  tctgggact  1140
tgacattgg  aaatccaat  acttcattg  tggcgtgtc  ctggggcca  gtgcccgag  1200
cgaggctcg  aagcactgg  gtgactgcc  gcagcagcg  gacgcagcc  tggagcgct  1260
gcacaccct  accagtgag  tgccccctg  ggccggggc  ctgtcctca  cctgagtgg  1320
cagcagtgt  ccggcacag  cccatcgag  cgggtccag  acccaacct  cgcacgagt  1380
tgttgcacg  ttacacagg  gggctgccc  accctgcac  acctatttt  tgagtctcg  1440
gacccgggt  tgtctgctc  tgaggggct  cggagttct  tattcacat  tgcaaacct  1500
ctgcctgac  cgctagtcc  tgcaaatat  caaaccccc  tactactgc  cacccgggc  1560
gtgctcaga  ccgcccagg  cccgcgctc  tcactcctg  ctctccacg  tgccccgtc  1620
c  1621



<210> 5175
<211> 400
<212> PRT
<213> Homo sapiens
<308> NP_003577
<400> 5175

Met Arg Gly Arg Arg Gly Asp Arg Met Thr Ile Asn Ile Gln Glu His 
  1               5                  10                  15
Met Ala Ile Asn Val Cys Pro Gly Pro Ile Arg Pro Ile Arg Gln Ile 
             20                  25                  30
Ser Asp Tyr Phe Pro Arg Gly Pro Gly Pro Glu Gly Gly Gly Gly Ser 
         35                  40                  45
Gly Gly Glu Ala Pro Ala His Leu Val Pro Leu Ala Leu Ala Pro Pro 
     50                  55                  60
Ala Ala Leu Leu Gly Ala Thr Thr Pro Glu Asp Gly Ala Glu Val Asp 
 65                  70                  75                  80
Ser Tyr Asp Ser Asp Asp Ala Thr Ala Leu Gly Lys Leu Glu Phe Asp 
                 85                  90                  95
Leu Leu Tyr Asp Arg Ala Ser Cys Thr Leu His Val Cys Ile Leu Arg 
             100                105                110
Ala Lys Gly Leu Lys Pro Met Asp Phe Asn Gly Leu Ala Asp Pro Tyr 
         115                120                125
Val Lys Leu His Leu Leu Pro Gly Ala Cys Lys Ala Asn Lys Leu Lys 
     130                135                140
Thr Lys Thr Gln Arg Asn Thr Leu Asn Pro Val Trp Asn Glu Asp Leu 
 145                150                155                160
Thr Tyr Ser Gly Ile Thr Asp Asp Asp Ile Thr His Lys Val Leu Arg 
                 165                170                175
Ile Ala Val Cys Asp Glu Asp Lys Leu Ser His Asn Glu Phe Ile Gly 
             180                185                190
Glu Ile Arg Val Pro Leu Arg Arg Leu Lys Pro Ser Gln Lys Lys His 
         195                200                205
Phe Asn Ile Cys Leu Glu Arg Gln Val Pro Leu Ala Ser Pro Ser Ser 
     210                215                220
Met Ser Ala Ala Leu Arg Gly Ile Ser Cys Tyr Leu Lys Asp Leu Glu 
 225                230                235                240
Gln Ala Glu Gln Gly Gln Gly Leu Leu Glu Glu Arg Gly Arg Ile Leu 
                 245                250                255
Leu Ser Leu Ser Tyr Ser Ser Arg Arg Arg Gly Leu Leu Val Gly Ile 
             260                265                270
Leu Arg Cys Ala His Leu Ala Ala Met Asp Val Asn Gly Tyr Ser Asp 
         275                280                285
Pro Tyr Val Lys Thr Tyr Leu Arg Pro Asp Val Asp Lys Lys Ser Lys 
     290                295                300
His Lys Thr Cys Val Lys Lys Lys Thr Leu Asn Pro Glu Phe Asn Glu 
 305                310                315                320
Glu Phe Phe Tyr Glu Ile Glu Leu Ser Thr Leu Ala Thr Lys Thr Leu 
                 325                330                335
Glu Val Thr Val Trp Asp Tyr Asp Ile Gly Lys Ser Asn Asp Phe Ile 
             340                345                350
Gly Gly Val Ser Leu Gly Pro Gly Ala Arg Gly Glu Ala Arg Lys His 
         355                360                365
Trp Ser Asp Cys Leu Gln Gln Arg Asp Ala Ala Leu Glu Arg Trp His 
     370                375                380
Thr Leu Thr Ser Glu Leu Pro Pro Ala Ala Gly Ala Leu Ser Ser Ala 
 385                390                395                400



<210> 5176
<211> 536
<212> DNA
<213> Rattus norvegicus
<308> AA874982
<400> 5176

ttttttttt  tttttttgt  gaaaataaa  ataaagcgg  ctttattca  aagataaag  60
tggtggtat  agttttggt  aataaagtt  ggctcaagt  ttttaacag  tctttaatg  120
cttcacaga  tggcatgcc  atggcattc  gaatgccaa  tacagatcg  tgctatcaa  180
gctgatgga  tttggactt  ttctaaagt  agactacac  catcttaaa  tatgagtaa  240
gagactgct  ggttctgaa  attagaaca  catactgag  aagtccctc  acttctcca  300
accctaagg  aggagtaca  ttgcttctg  cagctacat  ttcaacata  caacagaga  360
ggaggactg  ggtaactga  aaaaaaatg  aaagcaaaa  taaccaatg  aattggtgc  420
ggcagctgc  acttgtggc  aacccaagt  tatctgatg  ccattttct  cacatttgc  480
ctgacatct  ccaagcaga  ggtaactac  ttcttgaag  aatgtgcca  gactca  536



<210> 5177
<211> 876
<212> PRT
<213> Rattus norvegicus
<308> BAA11034
<400> 5177

Met Glu Leu Ile Thr Ile Leu Glu Lys Thr Val Ser Pro Asp Arg Leu 
  1               5                  10                  15
Glu Leu Glu Ala Ala Gln Lys Phe Leu Glu Arg Ala Ala Val Glu Asn 
             20                  25                  30
Leu Pro Thr Phe Leu Val Glu Leu Ser Arg Val Leu Ala Asn Pro Gly 
         35                  40                  45
Asn Ser Gln Val Ala Arg Val Ala Ala Gly Leu Gln Ile Lys Asn Ser 
     50                  55                  60
Leu Thr Ser Lys Asp Pro Asp Ile Lys Ala Gln Tyr Gln Gln Arg Trp 
 65                  70                  75                  80
Leu Ala Ile Asp Ala Asn Ala Arg Arg Glu Val Lys Asn Tyr Val Leu 
                 85                  90                  95
Gln Thr Leu Gly Thr Glu Thr Tyr Arg Pro Ser Ser Ala Ser Gln Cys 
             100                105                110
Val Ala Gly Ile Ala Cys Ala Glu Ile Pro Val Ser Gln Trp Pro Glu 
         115                120                125
Leu Ile Pro Gln Leu Val Ala Asn Val Thr Asn Pro Asn Ser Thr Glu 
     130                135                140
His Met Lys Glu Ser Thr Leu Glu Ala Ile Gly Tyr Ile Cys Gln Asp 
 145                150                155                160
Ile Asp Pro Glu Gln Leu Gln Asp Lys Ser Asn Glu Ile Leu Thr Ala 
                 165                170                175
Ile Ile Gln Gly Met Arg Lys Glu Glu Pro Ser Asn Asn Val Lys Leu 
             180                185                190
Ala Ala Thr Asn Ala Leu Leu Asn Ser Leu Glu Phe Thr Lys Ala Asn 
         195                200                205
Phe Asp Lys Glu Ser Glu Arg His Phe Ile Met Gln Val Val Cys Glu 
     210                215                220
Ala Thr Gln Cys Pro Asp Thr Arg Val Arg Val Ala Ala Leu Gln Asn 
 225                230                235                240
Leu Val Lys Ile Met Ser Leu Tyr Tyr Gln Tyr Met Glu Thr Tyr Met 
                 245                250                255
Gly Pro Ala Leu Phe Ala Ile Thr Ile Glu Ala Met Lys Ser Asp Ile 
             260                265                270
Asp Glu Val Ala Leu Gln Gly Ile Glu Phe Trp Ser Asn Val Cys Asp 
         275                280                285
Glu Glu Met Asp Leu Ala Ile Glu Ala Ser Glu Ala Ala Glu Gln Gly 
     290                295                300
Arg Pro Pro Glu His Thr Ser Lys Phe Tyr Ala Lys Gly Ala Leu Gln 
 305                310                315                320
Tyr Leu Val Pro Ile Leu Thr Gln Thr Leu Thr Lys Gln Asp Glu Asn 
                 325                330                335
Asp Asp Asp Asp Asp Trp Asn Pro Cys Lys Ala Ala Gly Val Cys Leu 
             340                345                350
Met Leu Leu Ser Thr Cys Cys Glu Asp Asp Ile Val Pro His Val Leu 
         355                360                365
Pro Phe Ile Lys Glu His Ile Lys Asn Pro Asp Trp Arg Tyr Arg Asp 
     370                375                380
Ala Ala Val Val Ala Phe Gly Ser Ile Leu Glu Gly Pro Glu Pro Asn 
 385                390                395                400
Gln Leu Lys Pro Leu Val Ile Gln Ala Met Pro Thr Leu Ile Glu Leu 
                 405                410                415
Met Lys Asp Pro Ser Val Val Val Arg Asp Thr Thr Ala Trp Thr Val 
             420                425                430
Gly Arg Ile Cys Glu Leu Leu Pro Glu Ala Ala Ile Asn Asp Val Tyr 
         435                440                445
Leu Ala Pro Leu Leu Gln Cys Leu Ile Glu Gly Leu Ser Ala Glu Pro 
     450                455                460
Arg Val Ala Ser Asn Val Cys Trp Ala Phe Ser Ser Leu Ala Glu Ala 
 465                470                475                480
Ala Tyr Glu Ala Ala Asp Val Ala Asp Asp Gln Glu Glu Pro Ala Thr 
                 485                490                495
Tyr Cys Leu Ser Ser Ser Phe Glu Leu Ile Val Gln Lys Leu Leu Glu 
             500                505                510
Thr Thr Asp Arg Pro Asp Gly His Gln Asn Asn Leu Arg Ser Ser Ala 
         515                520                525
Tyr Glu Ser Leu Met Glu Ile Val Lys Asn Ser Ala Lys Asp Cys Tyr 
     530                535                540
Pro Ala Val Gln Lys Thr Thr Leu Val Ile Met Glu Arg Leu Gln Gln 
 545                550                555                560
Val Leu Gln Met Glu Ser His Ile Gln Ser Thr Ser Asp Arg Ile Gln 
                 565                570                575
Phe Asn Asp Leu Gln Ser Leu Leu Cys Ala Thr Leu Gln Asn Val Leu 
             580                585                590
Arg Lys Val Gln His Gln Asp Ala Leu Gln Ile Ser Asp Val Val Met 
         595                600                605
Ala Ser Leu Leu Arg Met Phe Gln Ser Thr Ala Gly Ser Gly Gly Val 
     610                615                620
Gln Glu Asp Ala Leu Met Ala Val Ser Thr Leu Val Glu Val Leu Gly 
 625                630                635                640
Gly Glu Phe Leu Lys Tyr Met Glu Ala Phe Lys Pro Phe Leu Gly Ile 
                 645                650                655
Gly Leu Lys Asn Tyr Ala Glu Tyr Gln Val Cys Leu Ala Ala Val Gly 
             660                665                670
Leu Val Gly Asp Leu Cys Arg Ala Leu Gln Ser Asn Ile Leu Pro Phe 
         675                680                685
Cys Asp Glu Val Met Gln Leu Leu Leu Glu Asn Leu Gly Asn Glu Asn 
     690                695                700
Val His Arg Ser Val Lys Pro Gln Ile Leu Ser Val Phe Gly Asp Ile 
 705                710                715                720
Ala Leu Ala Ile Gly Gly Glu Phe Lys Lys Tyr Leu Glu Val Val Leu 
                 725                730                735
Asn Thr Leu Gln Gln Ala Ser Gln Ala Gln Val Asp Lys Ser Asp Phe 
             740                745                750
Asp Met Val Asp Tyr Leu Asn Glu Leu Arg Glu Ser Cys Leu Glu Ala 
         755                760                765
Tyr Thr Gly Ile Val Gln Gly Leu Lys Gly Asp Gln Glu Asn Val His 
     770                775                780
Pro Asp Val Met Leu Val Gln Pro Arg Val Glu Phe Ile Leu Ser Phe 
 785                790                795                800
Ile Asp His Ile Ala Gly Asp Glu Asp His Thr Asp Gly Val Val Ala 
                 805                810                815
Cys Ala Ala Gly Leu Ile Gly Asp Leu Cys Thr Ala Phe Gly Lys Asp 
             820                825                830
Val Leu Lys Leu Val Glu Ala Arg Pro Met Ile His Glu Leu Leu Thr 
         835                840                845
Glu Gly Arg Arg Ser Lys Thr Asn Lys Ala Lys Thr Leu Ala Thr Trp 
     850                855                860
Ala Thr Lys Glu Leu Arg Lys Leu Lys Asn Gln Ala 
 865                870                875



<210> 5178
<211> 438
<212> DNA
<213> Rattus norvegicus
<308> AA874993
<400> 5178

cggccgcct  actggtcct  gtcgccctc  tccaccgcc  ccgcccgcc  ccgcctcgt  60
ccctttcgc  ggcgccacc  ccgggtctc  tgcgggacc  gcgcttctc  tcaggaaac  120
gaggccggg  ggccgggcg  ctgggcaac  ttgaagtcg  cgctgaacg  ctgctgccg  180
gatctgtcc  cggtggggg  cgagggtgg  gagcaactc  gaagagaag  agaaggagg  240
gccaccgtc  gcgactggt  gaacgagga  agtcgtgat  aggcggtga  cagctgcgt  300
gcccggtgc  cgagcgaac  caggagggg  ggcgaggta  ttgcgaaga  gaaaggccc  360
gtcgtctcc  gtagtcacc  aaagaggag  gccaccatc  tgggagaaa  acggatctc  420
ccctcgtgc  gaattctt  438



<210> 5179
<211> 542
<212> DNA
<213> Rattus norvegicus
<308> AA874995
<400> 5179

ttttttttt  tttttttca  agtgctata  ccaatcatg  aggtgtaat  tatttatgt  60
ggaaataca  agatcacaa  tcttaagga  agagatgtg  cccccaaag  ttgcatttg  120
acacatcag  tacgctgag  gcattgtcc  cgggtttaa  attaagacc  agtgggaaa  180
cttatggtc  tatacactg  gtattagcc  tgctaggta  ggccatctg  cagacaaag  240
ggcctagtc  cctcccaca  gtcatgtcc  aagtcatct  cgtattatg  caacaggag  300
agcagggct  gctanagag  ggtatggtt  ggccagtta  tattgacat  ttagaatcc  360
gggggtaca  gtgttgtaa  aagccacct  cagaaggct  acggtacta  actggagaa  420
ctgtggaac  ggctgcact  accagggca  gctttctta  agaagcctc  gctattggt  480
tcatacagt  tccatttcc  aggaggcaa  ggcctgttt  gtatgcana  agactaaca  540
gg  542



<210> 5180
<211> 216
<212> PRT
<213> Rattus norvegicus
<308> NP_077792
<400> 5180

Met Asp Asp Ser Glu Lys Asp Phe Asn Leu Lys Val Val Leu Val Ser 
  1               5                  10                  15
Phe Lys Gln Cys Leu Thr Asp Lys Gly Glu Val Leu Leu Asp His Tyr 
             20                  25                  30
Ile Ala Gly Trp Lys Gly Leu Val Arg Phe Leu Asn Ser Leu Gly Ala 
         35                  40                  45
Val Phe Ser Phe Ile Ser Lys Asp Val Val Ala Lys Leu Gln Ile Met 
     50                  55                  60
Glu Arg Leu Arg Ser Ser Pro Gln Ser Glu His Tyr Thr Ser Leu Gln 
 65                  70                  75                  80
Ser Met Val Ala Tyr Glu Val Ser Asn Lys Leu Val Asp Met Asp His 
                 85                  90                  95
Arg Ser His Pro Arg His Pro His Ser Gly Cys Arg Thr Val Leu Arg 
             100                105                110
Leu His Arg Ala Leu His Trp Leu Gln Leu Phe Leu Asp Gly Leu Arg 
         115                120                125
Thr Ser Ser Glu Asp Ala Arg Thr Ser Thr Leu Cys Ser Glu Ala Tyr 
     130                135                140
Asn Ala Thr Leu Ala Asn Tyr His Ser Trp Ile Val Arg Gln Ala Val 
 145                150                155                160
Thr Val Ala Phe Cys Ala Leu Pro Ser Arg Lys Val Phe Leu Glu Ala 
                 165                170                175
Met Asn Met Glu Ser Thr Glu Gln Ala Val Glu Met Leu Gly Glu Ala 
             180                185                190
Leu Pro Phe Ile Glu His Val Tyr Asp Ile Ser Gln Lys Leu Tyr Ala 
         195                200                205
Glu His Ser Leu Leu Asp Leu Pro 
     210                215



<210> 5181
<211> 412
<212> DNA
<213> Rattus norvegicus
<308> AA875004
<400> 5181

ttttttttt  aatgattac  aaaaataaa  atgtgttta  ttttaagaa  aagaaaagc  60
ctggccaag  acaaacact  ggataaaga  gtcaccgtg  cctgccaaa  caacagaca  120
ataggacac  gccaagatt  ggtgtctag  ccaaaggtc  gagtgacag  aagttgctg  180
ccgtgtctc  tagcaagac  ccattagag  tgggtgcga  gtgctgcta  aggcacctc  240
gcatcgcac  gcctcagga  gtcacatgt  ctcaacact  cacttgtag  caagctcct  300
cacagcttt  ttgctggca  gcctggcaa  gcgcttctg  tcaaagcca  tggatctgt  360
cactccatc  cagcgatac  ccggccaaa  gttgaatct  ttgggagga  ga  412



<210> 5182
<211> 2225
<212> DNA
<213> Homo sapiens
<308> BC006350
<400> 5182

ggcacgagg  gtctctctg  ccccgccgc  gccatggcg  cagctccgc  gctttccaa  60
gccgagtat  tgaagcgtt  cttgtccgg  gcagatgcc  gcgtcgacc  gggatctga  120
tccggtcgc  agcgtcgca  aaagcggcc  aagcctggc  gggccggcg  caagggaat  180
cggattgtg  atgatgatg  gagctggac  gctatctcc  caaccaaac  agaaaagga  240
gaagaggaa  atgatggag  tttgcctgt  gtggcagag  ttgtggatg  gcggccaga  300
gaggtaaag  agatggagg  ctttcgttc  agtgccaaa  ggaagcttc  gggaggcca  360
aacgaagac  taccctcaa  cagacattt  cgtcacgat  ccccggatt  atctcctag  420
agggtccgt  atggtaccc  agatccatc  cctaggaag  accgtcatg  caccccgga  480
ccatctcct  ggagggccc  tcatgacac  ccagatcct  ctcccctca  aggggctcg  540
catgactca  acacatctc  tcccaggag  atccgtcat  actcctcag  cacttcacc  600
ccaaggagg  cccgtcatg  ttctccaga  ccttctccc  caaggaggc  tcagcataa  660
tcttcaggt  catctccta  gagagtccg  catgattca  cagatccct  tcctcctag  720
cgagcccgt  atggttcct  agatatctc  tcccccaga  gggtccata  caactcccc  780
gacacatct  ggaggactc  tggctcttc  gacacacag  aactcagaa  ggcccgtca  840
gactcccct  atttggctc  taatgtcac  tattccctg  ccagaacca  aagtggtaa  900
gccccagaa  gagcctcta  caagacttc  ccacattgg  aggagtcag  agcctccca  960
ttgtcattc  caaagaaca  caaatatga  tatgaccct  acatctctc  tccacgaaa  1020
aagcaagca  aatcccatt  tggagacaa  aagcagctt  attccaaag  tgactgcca  1080
aaagcaact  attcagacc  ttcttctcc  cggcataaa  aaagtccag  gcaccagga  1140
tctgattca  atctgtcac  tccacggaa  agacctaga  accggagct  tgattctga  1200
ctctctcca  caaggagga  acagaggac  aaatcttct  attctgacc  gtccccgcc  1260
cgaaggagt  agcctcctg  aaagaaggc  gcacacatg  attctgggg  taaaactgg  1320
ttggtgtta  ctgacatac  gcgagaaca  caggagctc  aggaacagg  tcaagaaac  1380
atggcattt  aagctgaat  tcaatatgc  gaaaccgta  ttcgagata  gtctggtcg  1440
aagaggaat  tgaaactcg  acgtttaga  caaaggagg  aagcagaaa  ggactcaga  1500
agagatgag  tgtatgccc  gtggggaaa  gggcttgcc  agagccggc  acagcaaca  1560
aatgtggag  atgcaatga  agagatgca  aagcctctg  cccgctata  tgatgacga  1620
gatctggat  ggatgctaa  agaacagga  agagagggg  accctatgg  caacttcat  1680
aagaagaat  aggccaagg  gaacaagaa  aaaaaagtg  gacctcgct  cagtggtcc  1740
gcacctcct  ccaacagat  taatatctg  cctggatat  gctgggacg  agtggacag  1800
tccaatgga  ttgaacaga  gcgctttgc  aggcttgcc  gcaagaagg  agtggagga  1860
cttgcctac  aatggagtg  tgaggatat  taactttcc  gaggctgtg  gggtggctg  1920
gctgtggta  tgggcatag  cagcgagat  tccagtggt  acagttgtc  gtgctaata  1980
ttggagccc  cacagacca  caacttgtt  aatgccagt  ttgaccaca  aagaatatt  2040
gagacctga  gtttggact  aggtacctg  acttcttgg  tgtgacagc  ccggctgtt  2100
ctggctttc  gaggaagca  tgatttctc  ttgaccagg  tttgttctt  gtagggttt  2160
tctttttct  ttttaaata  acatgtatt  attttttta  aaaaaaaaa  aaaaaaaaa  2220
aaaaa  2225



<210> 5183
<211> 620
<212> PRT
<213> Homo sapiens
<308> BC006350
<400> 5183

Met Ala Ala Ala Pro Pro Leu Ser Lys Ala Glu Tyr Leu Lys Arg Tyr 
  1               5                  10                  15
Leu Ser Gly Ala Asp Ala Gly Val Asp Arg Gly Ser Glu Ser Gly Arg 
             20                  25                  30
Lys Arg Arg Lys Lys Arg Pro Lys Pro Gly Gly Ala Gly Gly Lys Gly 
         35                  40                  45
Met Arg Ile Val Asp Asp Asp Val Ser Trp Thr Ala Ile Ser Thr Thr 
     50                  55                  60
Lys Leu Glu Lys Glu Glu Glu Glu Asp Asp Gly Asp Leu Pro Val Val 
 65                  70                  75                  80
Ala Glu Phe Val Asp Glu Arg Pro Glu Glu Val Lys Gln Met Glu Ala 
                 85                  90                  95
Phe Arg Ser Ser Ala Lys Trp Lys Leu Leu Gly Gly His Asn Glu Asp 
             100                105                110
Leu Pro Ser Asn Arg His Phe Arg His Asp Thr Pro Asp Ser Ser Pro 
         115                120                125
Arg Arg Val Arg His Gly Thr Pro Asp Pro Ser Pro Arg Lys Asp Arg 
     130                135                140
His Asp Thr Pro Asp Pro Ser Pro Arg Arg Ala Arg His Asp Thr Pro 
 145                150                155                160
Asp Pro Ser Pro Leu Arg Gly Ala Arg His Asp Ser Asp Thr Ser Pro 
                 165                170                175
Pro Arg Arg Ile Arg His Asp Ser Ser Asp Thr Ser Pro Pro Arg Arg 
             180                185                190
Ala Arg His Asp Ser Pro Asp Pro Ser Pro Pro Arg Arg Pro Gln His 
         195                200                205
Asn Ser Ser Gly Ala Ser Pro Arg Arg Val Arg His Asp Ser Pro Asp 
     210                215                220
Pro Ser Pro Pro Arg Arg Ala Arg His Gly Ser Ser Asp Ile Ser Ser 
 225                230                235                240
Pro Arg Arg Val His Asn Asn Ser Pro Asp Thr Ser Arg Arg Thr Leu 
                 245                250                255
Gly Ser Ser Asp Thr Gln Gln Leu Arg Arg Ala Arg His Asp Ser Pro 
             260                265                270
Asp Leu Ala Pro Asn Val Thr Tyr Ser Leu Pro Arg Thr Lys Ser Gly 
         275                280                285
Lys Ala Pro Glu Arg Ala Ser Ser Lys Thr Ser Pro His Trp Lys Glu 
     290                295                300
Ser Gly Ala Ser His Leu Ser Phe Pro Lys Asn Ser Lys Tyr Glu Tyr 
 305                310                315                320
Asp Pro Asp Ile Ser Pro Pro Arg Lys Lys Gln Ala Lys Ser His Phe 
                 325                330                335
Gly Asp Lys Lys Gln Leu Asp Ser Lys Gly Asp Cys Gln Lys Ala Thr 
             340                345                350
Asp Ser Asp Leu Ser Ser Pro Arg His Lys Gln Ser Pro Gly His Gln 
         355                360                365
Asp Ser Asp Ser Asp Leu Ser Pro Pro Arg Asn Arg Pro Arg His Arg 
     370                375                380
Ser Ser Asp Ser Asp Leu Ser Pro Pro Arg Arg Arg Gln Arg Thr Lys 
 385                390                395                400
Ser Ser Asp Ser Asp Leu Ser Pro Pro Arg Arg Ser Gln Pro Pro Gly 
                 405                410                415
Lys Lys Ala Ala His Met Tyr Ser Gly Ala Lys Thr Gly Leu Val Leu 
             420                425                430
Thr Asp Ile Gln Arg Glu Gln Gln Glu Leu Lys Glu Gln Asp Gln Glu 
         435                440                445
Thr Met Ala Phe Glu Ala Glu Phe Gln Tyr Ala Glu Thr Val Phe Arg 
     450                455                460
Asp Lys Ser Gly Arg Lys Arg Asn Leu Lys Leu Glu Arg Leu Glu Gln 
 465                470                475                480
Arg Arg Lys Ala Glu Lys Asp Ser Glu Arg Asp Glu Leu Tyr Ala Gln 
                 485                490                495
Trp Gly Lys Gly Leu Ala Gln Ser Arg Gln Gln Gln Gln Asn Val Glu 
             500                505                510
Asp Ala Met Lys Glu Met Gln Lys Pro Leu Ala Arg Tyr Ile Asp Asp 
         515                520                525
Glu Asp Leu Asp Arg Met Leu Arg Glu Gln Glu Arg Glu Gly Asp Pro 
     530                535                540
Met Ala Asn Phe Ile Lys Lys Asn Lys Ala Lys Glu Asn Lys Asn Lys 
 545                550                555                560
Lys Val Arg Pro Arg Tyr Ser Gly Pro Ala Pro Pro Pro Asn Arg Phe 
                 565                570                575
Asn Ile Trp Pro Gly Tyr Arg Trp Asp Gly Val Asp Arg Ser Asn Gly 
             580                585                590
Phe Glu Gln Lys Arg Phe Ala Arg Leu Ala Ser Lys Lys Ala Val Glu 
         595                600                605
Glu Leu Ala Tyr Lys Trp Ser Val Glu Asp Met Ter 
     610                615                620



<210> 5184
<211> 530
<212> DNA
<213> Rattus norvegicus
<308> AA875019
<400> 5184

ttttttttt  tttttttgg  tttatagtg  aagtttatt  tttttaatc  aagtacaat  60
agctactag  tacatacag  aaaaaacaa  acggccacc  agcaatgat  atagtctgt  120
acaggtgca  aggagggaa  cttgttggg  gtcctgtgg  tccacacct  acttcagca  180
ttaagctga  cctccctcc  cagatcagt  aaaaaaaat  ttaacagtg  cttgcttgg  240
tagagcaag  ttctaaatt  tcttgggga  actggagaa  ttttaaaaa  gaaagtggt  300
aaacaagat  gaaacgtgg  gacacaaga  gcttcctga  aaagaagct  caggaggtc  360
tggcttcag  tcacctcaa  tcgaatcag  ttagaggag  gactccatt  aaaccaagg  420
tcatatgta  ttggtccgg  tgagggctc  ctcagccag  tggccgctc  catccgtga  480
cttctccca  tcagtctgc  cgaccacaa  acctatggc  cttcaacatc  530



<210> 5185
<211> 1386
<212> PRT
<213> Rattus norvegicus
<308> BAA85182
<400> 5185

Met Tyr Pro Asn Trp Gly Arg Tyr Gly Gly Ser Ser His Tyr Pro Pro 
  1               5                  10                  15
Pro Pro Val Pro Pro Pro Pro Pro Pro Val Ala Leu Pro Glu Ala Ser 
             20                  25                  30
Pro Gly Pro Gly Tyr Ser Ser Ser Thr Ala Pro Ala Ala Pro Ser Ser 
         35                  40                  45
Ser Gly Phe Met Ser Phe Arg Glu Gln His Leu Ala Gln Leu Gln Gln 
     50                  55                  60
Leu Gln Gln Met His Gln Lys Gln Met Gln Ser Val Leu Gln Pro His 
 65                  70                  75                  80
His Leu Pro Pro Pro Pro Leu Pro Pro Pro Pro Val Met Pro Gly Gly 
                 85                  90                  95
Gly Tyr Gly Asp Trp Gln Pro Pro Pro Pro Pro Met Pro Pro Pro Pro 
             100                105                110
Gly Pro Ala Leu Ser Tyr Gln Lys Gln Gln Gln Tyr Lys His Gln Met 
         115                120                125
Ile His His Gln Arg Asp Gly Pro Pro Gly Leu Val Pro Met Glu Leu 
     130                135                140
Glu Ser Pro Pro Glu Ser Pro Pro Val Pro Pro Gly Ser Tyr Met Pro 
 145                150                155                160
Pro Ser Gln Ser Tyr Met Pro Pro Pro Gln Pro Pro Pro Ser Tyr Tyr 
                 165                170                175
Pro Pro Ser Ser Ala Gln Pro Tyr Leu Pro Pro Ala Gln Pro Ser Pro 
             180                185                190
Ser Lys Pro Gln Leu Pro Pro Pro Pro Ser Ile Pro Ser Gly Asn Lys 
         195                200                205
Thr Ala Ile Gln Gln Glu Pro Leu Glu Ser Gly Ala Lys Asn Lys Thr 
     210                215                220
Ala Glu Gln Lys Gln Ala Ala Pro Glu Pro Asp Pro Ser Thr Met Thr 
 225                230                235                240
Pro Gln Glu Gln Gln Gln Tyr Trp Tyr Arg Gln His Leu Leu Ser Leu 
                 245                250                255
Gln Gln Arg Thr Lys Val His Leu Pro Gly His Lys Lys Gly Leu Val 
             260                265                270
Thr Ala Lys Asp Val Pro Glu Pro Ile Lys Glu Glu Ala Pro Gly Pro 
         275                280                285
Ala Ala Ser Gln Val Ala Glu Pro Leu Ala Ala Glu Lys Pro Pro Leu 
     290                295                300
Pro Pro Pro Asn Glu Glu Ala Pro Pro Pro Leu Ser Pro Glu Glu Pro 
 305                310                315                320
Gln Ser Glu Asp Ser Glu Asp Ser Glu Asp Ser Glu Glu Asp Ala Arg 
                 325                330                335
Phe Lys Gln Leu Lys Ala Ile Ala Ala His Trp Gln Ala Ala Ala Ala 
             340                345                350
His Trp Gln Gln Gln Gln Gln Gln Arg Val Gly Phe Gln Tyr Gln Gly 
         355                360                365
Ile Met Gln Arg His Thr Gln Leu Gln Gln Ile Leu Gln Gln Tyr Gln 
     370                375                380
Gln Val Ile Gln His Ser Pro His Ile Gln Thr Met Ser Leu Asp Val 
 385                390                395                400
Gln Leu Arg His Tyr Glu Met Gln Gln Gln Gln Phe Gln His Leu Phe 
                 405                410                415
Gln Asp Trp Glu Arg Glu Phe Gln Leu Trp Glu Glu Gln Leu His Ser 
             420                425                430
Tyr Pro His Lys Asp Gln Leu Gln Glu Tyr Glu Lys Gln Trp Lys Thr 
         435                440                445
Trp Gln Gly His Met Lys Ala Thr Gln Thr Tyr Leu Gln Glu Lys Val 
     450                455                460
Asn Ser Phe Gln Thr Val Lys Ser Gln Tyr Leu Gly Asn Met Ala Met 
 465                470                475                480
Pro Pro Pro Phe Val Pro Tyr Ser Gln Met Pro Pro Pro Leu Pro Thr 
                 485                490                495
Met Pro Pro Pro Val Leu Pro Pro Ser Leu Pro Pro Pro Val Met Pro 
             500                505                510
Pro Ala Leu Pro Thr Ser Ile Pro Pro Pro Gly Met Pro Pro Pro Val 
         515                520                525
Met Pro Pro Ser Leu Pro Thr Ser Val Pro Pro Pro Gly Met Pro Pro 
     530                535                540
Ser Leu Ser Ser Gly Pro Pro Pro Val Leu Pro Pro Pro Ala Leu Ser 
 545                550                555                560
Ser Ala Gly Ser Pro Pro Val Leu Pro Pro Pro Ala Leu Pro Gly Gly 
                 565                570                575
Pro Pro Ile Leu Pro Leu Pro Pro Leu Ser Ser Ala Thr Pro Pro Pro 
             580                585                590
Gly Ile Pro Pro Pro Gly Ala Pro Gln Gly Met Pro Pro Gln Leu Thr 
         595                600                605
Ala Pro Leu Pro Pro Ala Ser Gly Ser Gln Asn Ser Gln Ile Pro Glu 
     610                615                620
Lys Pro Arg Gln Ala Leu Leu Pro Thr Pro Val Ser Phe Gly Ser Thr 
 625                630                635                640
Pro Pro Ser Pro Tyr His Pro Pro Pro Gln Ser Glu Gln Val Asn Ser 
                 645                650                655
Lys Pro Leu Asn Lys Val Phe Ser Ser Glu Gln Gly Leu Gly Glu Ser 
             660                665                670
Ser Ala Leu Ser Gln Ser Ile Ile Ala Ala Lys Asp Thr Pro Val Lys 
         675                680                685
Ser Gly Gly Leu Leu Ala Asp Pro Pro Lys Gly Ser Phe Leu Glu Gly 
     690                695                700
Pro Arg Gly Pro Arg Glu Gln Lys Glu Gln Leu Gln Lys Leu Lys Asp 
 705                710                715                720
Phe Gly Ser Glu Pro Gln Met Ala Asp His Leu Pro Pro Pro Asp Ser 
                 725                730                735
Arg Leu Gln Asn Pro Ser Arg Pro Gly Met Tyr Pro Pro Pro Gly Ser 
             740                745                750
Tyr Arg Pro Pro Pro Pro Met Gly Lys Pro Pro Gly Ser Ile Val Arg 
         755                760                765
Pro Ser Ala Pro Pro Ala Arg Ser Ser Ile Pro Met Thr Arg Pro Pro 
     770                775                780
Val Pro Ile Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
 785                790                795                800
Pro Pro Val Ile Lys Ser Lys Thr Ser Ser Val Lys Gln Glu Arg Trp 
                 805                810                815
Asp Glu Asp Ser Phe Phe Gly Leu Trp Asp Thr Asn Asp Asp Gln Gly 
             820                825                830
Leu Asn Ser Glu Phe Lys Arg Asp Thr Ala Thr Ile Pro Ser Ala Pro 
         835                840                845
Val Leu Pro Pro Pro Pro Val His Ser Ser Ile Pro Pro Pro Gly Pro 
     850                855                860
Met Pro Met Gly Met Pro Pro Met Ser Lys Pro Pro Pro Val Gln His 
 865                870                875                880
Thr Val Asp Tyr Gly His Gly Arg Asp Met Pro Thr Asn Lys Val Glu 
                 885                890                895
Gln Ile Pro Tyr Gly Glu Arg Ile Thr Leu Arg Pro Asp Pro Leu Pro 
             900                905                910
Glu Arg Ser Thr Phe Asp Ala Asp His Ala Gly Gln Arg Asp Arg Tyr 
         915                920                925
Asp Arg Asp Arg Asp Arg Glu Pro Tyr Phe Asp Arg Pro Ser Asn Ile 
     930                935                940
Thr Asp His Arg Asp Phe Lys Arg Asp Arg Glu Thr His Arg Asp Arg 
 945                950                955                960
Asp Arg Asp Arg Val Leu Asp Tyr Glu Arg Asp Arg Phe Asp Arg Glu 
                 965                970                975
Arg Arg Pro Arg Asp Asp Arg Asn Gln Ser Tyr Arg Asp Lys Lys Asp 
             980                985                990
His Ser Ser Ser Arg Arg Gly Gly Phe Asp Arg Pro Ser Tyr Asp Arg 
         995                1000                1005
Lys Ser Asp Arg Pro Pro Tyr Glu Gly Pro Pro Met Phe Gly Gly Glu 
     1010                1015                1020
Arg Arg Thr Tyr Pro Glu Glu Arg Met Pro Leu Pro Ala Pro Ala Leu 
 1025                1030                1035                1040
Gly His Gln Pro Pro Pro Val Pro Arg Val Glu Lys Lys Pro Glu Ser 
                 1045                1050                1055
Lys Asn Val Asp Asp Ile Leu Lys Pro Pro Gly Arg Glu Ser Arg Pro 
             1060                1065                1070
Glu Arg Ile Val Val Ile Met Arg Gly Leu Pro Gly Ser Gly Lys Thr 
         1075                1080                1085
His Val Ala Lys Leu Ile Arg Asp Lys Glu Val Glu Phe Gly Gly Pro 
     1090                1095                1100
Ala Pro Arg Val Leu Ser Leu Asp Asp Tyr Phe Ile Ala Glu Val Glu 
 1105                1110                1115                1120
Lys Glu Glu Lys Asp Pro Asp Ser Gly Lys Lys Val Lys Lys Lys Val 
                 1125                1130                1135
Met Glu Tyr Glu Tyr Glu Ala Asp Met Glu Glu Thr Tyr Arg Thr Ser 
             1140                1145                1150
Met Phe Lys Thr Phe Lys Lys Thr Leu Asp Asp Gly Phe Phe Pro Phe 
         1155                1160                1165
Ile Ile Leu Asp Ala Ile Asn Asp Arg Val Arg His Phe Asp Gln Phe 
     1170                1175                1180
Trp Ser Ala Ala Lys Thr Lys Gly Phe Glu Val Tyr Leu Ala Glu Met 
 1185                1190                1195                1200
Ser Ala Asp Asn Gln Thr Cys Gly Lys Arg Asn Ile His Gly Arg Lys 
                 1205                1210                1215
Leu Lys Glu Ile Asn Lys Met Ala Glu His Trp Glu Val Ala Pro Arg 
             1220                1225                1230
His Met Met Arg Leu Asp Ile Arg Ser Leu Leu Gln Asp Ala Ala Ile 
         1235                1240                1245
Glu Glu Val Glu Met Glu Asp Phe Asp Ala Asn Ile Glu Asp Gln Lys 
     1250                1255                1260
Glu Glu Lys Lys Asp Ala Glu Glu Glu Glu Ser Glu Leu Gly Tyr Thr 
 1265                1270                1275                1280
Pro Lys Ser Lys Trp Glu Met Asp Thr Ser Glu Ala Lys Leu Asp Lys 
                 1285                1290                1295
Leu Asp Gly Leu Arg Thr Gly Thr Lys Arg Lys Arg Asp Trp Glu Ala 
             1300                1305                1310
Ile Ala Ser Arg Met Glu Asp Tyr Leu Gln Leu Pro Asp Asp Tyr Glu 
         1315                1320                1325
Thr Arg Ala Ser Glu Pro Gly Lys Lys Arg Val Arg Trp Ala Asp Leu 
     1330                1335                1340
Glu Glu Lys Lys Asp Ala Asp Arg Lys Arg Ala Ile Gly Phe Val Val 
 1345                1350                1355                1360
Gly Gln Thr Asp Trp Glu Lys Ile Thr Asp Glu Ser Gly His Leu Ala 
                 1365                1370                1375
Glu Arg Ala Leu Asn Arg Thr Lys Tyr Ile 
             1380                1385



<210> 5186
<211> 1601
<212> DNA
<213> Homo sapiens
<308> BC007792
<400> 5186

ttttgatag  ccatcctat  accggaagt  tgaccgacc  gtctatgaa  gaccatcca  60
gtttggagg  gaacgaagg  cttatcctg  ggagcgaat  cctctgcca  ctccttcac  120
gagccacca  cctcctcca  ctccacgag  cgagaagaa  cctgaatca  agaatgtgg  180
cgatatttt  aaaccaccg  gccgggaga  cagacctga  agaattgtt  ttataatga  240
aggattacc  ggcagtgga  agacacatg  tgcaaaact  attcgagat  aggaggtag  300
atttggagg  cctgcaccc  gagttctaa  cctggatga  tacttcatc  ctgaagtgg  360
aaaagaaga  aaagatcca  attctggaa  gaaagtgaa  aagaaggta  tggaatatg  420
atatgaagc  gagatggag  agacttacc  caccagcat  ttcaaaact  tcaaaaaga  480
tctggatga  ggctttttt  ccttcatca  cctggatgc  atcaatgac  gagttaggc  540
ttttgacca  ttttggagt  cagcaaaaa  caagggatt  gaggtatat  tggctgaaa  600
gagtgcaga  aaccagact  gtggcaaga  aaatattca  ggaagaaag  ttaaagaaa  660
aaataagat  gctgatcac  gggaaactg  acctcgtca  atgatgcgt  tagatattc  720
ttctttgct  caagatgct  ctattgaag  ggtagagat  gaagatttt  atgcaaata  780
cgaagaaca  aaagaagaa  agaaagatg  agaggaaga  gaaagcgaa  tgggttaca  840
tccgaaaag  aaatgggag  tggacacat  tgaggcaaa  ctagacaag  tggatggct  900
gaggactgg  actaaaagg  aacgtgact  ggaggccat  gccagcaga  tggaggatt  960
tcttcagct  cccgatgat  atgatactc  tgcttctga  cctgggaag  agagggtca  1020
atgggcaga  ctggaagag  agaaggatg  agataggaa  agggccata  gttttgtgg  1080
cggacagac  gattgggag  agatcacag  tgaaagtgg  cacctggct  aaaaagccc  1140
caatcgaac  aaatatata  gagacttag  ttttgaacg  agtcattat  cctctaagg  1200
ggttcgctt  gaggtggtc  gaagccaag  cctcgcgga  cttctttgt  tgtcacctt  1260
cttccacgt  tcagttctt  ttttgtttc  actgcttta  tttttttta  agttctcca  1320
tgtccccaa  aggtattag  atcttgctg  acccaagca  gacgttaat  tttctttta  1380
ctgttttgg  gagggaggg  gtgatagct  aactgctga  gccaggcgg  ggtctgctg  1440
aggattcca  cagagagta  ttcctccac  gtacaatgt  acagactat  tctatcatc  1500
ttgctttgt  gctgtttct  ttttttact  tatgtaact  gtagctgat  gtactagga  1560
taaaaacaa  aaactttca  gataaaaaa  aaaaaaaaa  a  1601



<210> 5187
<211> 1822
<212> PRT
<213> Homo sapiens
<308> P49750
<400> 5187

Met Tyr Pro Asn Trp Gly Arg Tyr Gly Gly Ser Ser His Tyr Pro Pro 
  1               5                  10                  15
Pro Pro Val Pro Pro Pro Pro Pro Val Ala Leu Pro Glu Ala Ser Pro 
             20                  25                  30
Gly Pro Gly Tyr Ser Ser Ser Thr Thr Pro Ala Ala Pro Ser Ser Ser 
         35                  40                  45
Gly Phe Met Ser Phe Arg Glu Gln His Leu Ala Gln Leu Gln Gln Leu 
     50                  55                  60
Gln Gln Met His Gln Lys Gln Met Gln Cys Val Leu Gln Pro His His 
 65                  70                  75                  80
Leu Pro Pro Pro Pro Leu Pro Pro Pro Pro Val Met Pro Gly Gly Gly 
                 85                  90                  95
Tyr Gly Asp Trp Gln Pro Pro Pro Pro Pro Met Pro Pro Pro Pro Gly 
             100                105                110
Pro Ala Leu Ser Tyr Gln Lys Gln Gln Gln Tyr Lys His Gln Met Leu 
         115                120                125
His His Gln Arg Asp Gly Pro Pro Gly Leu Val Pro Met Glu Leu Glu 
     130                135                140
Ser Pro Pro Glu Ser Pro Pro Val Pro Pro Gly Ser Tyr Met Pro Pro 
 145                150                155                160
Ser Gln Ser Tyr Met Pro Pro Pro Gln Pro Pro Pro Ser Tyr Tyr Pro 
                 165                170                175
Pro Thr Ser Ser Gln Pro Tyr Leu Pro Pro Ala Gln Pro Ser Pro Ser 
             180                185                190
Gln Ser Pro Pro Ser Gln Ser Tyr Leu Ala Pro Thr Pro Ser Tyr Ser 
         195                200                205
Ser Ser Ser Ser Ser Ser Gln Ser Tyr Leu Ser His Ser Gln Ser Tyr 
     210                215                220
Leu Pro Ser Ser Gln Ala Ser Pro Ser Arg Pro Ser Gln Gly His Ser 
 225                230                235                240
Lys Ser Gln Leu Leu Ala Pro Pro Pro Pro Ser Ala Pro Pro Gly Asn 
                 245                250                255
Lys Thr Thr Val Gln Gln Glu Pro Leu Glu Ser Gly Ala Lys Asn Lys 
             260                265                270
Ser Thr Glu Gln Gln Gln Ala Ala Pro Glu Pro Asp Pro Ser Thr Met 
         275                280                285
Thr Pro Gln Glu Gln Gln Gln Tyr Trp Tyr Arg Gln His Leu Leu Ser 
     290                295                300
Leu Gln Gln Arg Thr Lys Val His Leu Pro Gly His Lys Lys Gly Pro 
 305                310                315                320
Val Val Ala Lys Asp Thr Pro Glu Pro Val Lys Glu Glu Val Thr Val 
                 325                330                335
Pro Ala Thr Ser Gln Val Pro Glu Ser Pro Ser Ser Glu Glu Pro Pro 
             340                345                350
Leu Pro Pro Pro Asn Glu Glu Val Pro Pro Pro Leu Pro Pro Glu Glu 
         355                360                365
Pro Gln Ser Glu Asp Pro Glu Glu Asp Ala Arg Leu Lys Gln Leu Gln 
     370                375                380
Ala Ala Ala Ala His Trp Gln Gln His Gln Gln His Arg Val Gly Phe 
 385                390                395                400
Gln Tyr Gln Gly Ile Met Gln Lys His Thr Gln Leu Gln Gln Ile Leu 
                 405                410                415
Gln Gln Tyr Gln Gln Ile Ile Gln Pro Pro Pro His Ile Gln Ala Thr 
             420                425                430
Thr Pro Pro Pro Gly Ile Pro Pro Pro Gly Val Pro Gln Gly Ile Pro 
         435                440                445
Pro Gln Leu Thr Ala Ala Pro Val Pro Pro Ala Ser Ser Ser Gln Ser 
     450                455                460
Ser Gln Val Pro Glu Lys Pro Arg Pro Ala Leu Leu Pro Thr Pro Val 
 465                470                475                480
Ser Phe Gly Ser Ala Pro Pro Thr Thr Tyr His Pro Pro Leu Gln Ser 
                 485                490                495
Ala Gly Pro Ser Glu Gln Val Asn Ser Lys Ala Pro Leu Ser Lys Ser 
             500                505                510
Ala Leu Pro Tyr Ser Ser Phe Ser Ser Asp Gln Gly Leu Gly Glu Ser 
         515                520                525
Ser Ala Ala Pro Ser Gln Pro Ile Thr Ala Val Lys Asp Met Pro Val 
     530                535                540
Arg Ser Gly Gly Leu Leu Pro Asp Pro Pro Arg Ser Ser Tyr Leu Glu 
 545                550                555                560
Ser Pro Arg Gly Pro Arg Phe Asp Gly Pro Arg Arg Phe Glu Asp Leu 
                 565                570                575
Gly Ser Arg Cys Glu Gly Pro Arg Pro Lys Gly Pro Arg Phe Glu Gly 
             580                585                590
Asn Arg Pro Asp Gly Pro Arg Pro Arg Tyr Glu Gly His Pro Ala Glu 
         595                600                605
Gly Thr Lys Ser Lys Trp Gly Met Ile Pro Arg Gly Pro Ala Ser Gln 
     610                615                620
Phe Tyr Ile Thr Pro Ser Thr Ser Leu Ser Pro Arg Gln Ser Gly Pro 
 625                630                635                640
Gln Trp Lys Gly Pro Lys Pro Ala Phe Gly Gln Gln His Gln Gln Gln 
                 645                650                655
Pro Lys Ser Gln Ala Glu Pro Leu Ser Gly Asn Lys Glu Pro Leu Ala 
             660                665                670
Asp Thr Ser Ser Asn Gln Gln Lys Asn Phe Lys Met Gln Ser Ala Ala 
         675                680                685
Phe Ser Ile Ala Ala Asp Val Lys Asp Val Lys Ala Ala Gln Ser Asn 
     690                695                700
Glu Asn Leu Ser Asp Ser Gln Gln Glu Pro Pro Lys Ser Glu Val Ser 
 705                710                715                720
Glu Gly Pro Val Glu Pro Ser Asn Trp Asp Gln Asn Val Gln Ser Met 
                 725                730                735
Glu Thr Gln Ile Asp Lys Ala Gln Ala Val Thr Gln Pro Val Pro Leu 
             740                745                750
Ala Asn Lys Pro Val Pro Ala Gln Ser Thr Phe Pro Ser Lys Thr Gly 
         755                760                765
Gly Met Glu Gly Gly Thr Ala Val Ala Thr Ser Ser Leu Thr Ala Asp 
     770                775                780
Asn Asp Phe Lys Pro Val Gly Ile Gly Leu Pro His Ser Glu Asn Asn 
 785                790                795                800
Gln Asp Lys Gly Leu Pro Arg Pro Asp Asn Arg Asp Asn Arg Leu Glu 
                 805                810                815
Gly Asn Arg Gly Asn Ser Ser Ser Tyr Arg Gly Pro Gly Gln Ser Arg 
             820                825                830
Met Glu Asp Thr Arg Asp Lys Gly Leu Val Asn Arg Gly Arg Gly Gln 
         835                840                845
Ala Ile Ser Arg Gly Pro Gly Leu Val Lys Gln Glu Asp Phe Arg Asp 
     850                855                860
Lys Met Met Gly Arg Arg Glu Asp Ser Arg Glu Lys Met Asn Arg Gly 
 865                870                875                880
Glu Gly Ser Arg Asp Arg Gly Leu Val Arg Pro Gly Ser Ser Arg Glu 
                 885                890                895
Lys Val Pro Gly Gly Leu Gln Gly Ser Gln Asp Arg Gly Ala Ala Gly 
             900                905                910
Ser Arg Glu Arg Gly Pro Pro Arg Arg Ala Gly Ser Gln Glu Arg Gly 
         915                920                925
Pro Leu Arg Arg Ala Gly Ser Arg Glu Arg Ile Pro Pro Arg Arg Ala 
     930                935                940
Gly Ser Arg Glu Arg Gly Pro Pro Arg Gly Pro Gly Ser Arg Glu Arg 
 945                950                955                960
Gly Leu Gly Arg Ser Asp Phe Gly Arg Asp Arg Gly Pro Phe Arg Pro 
                 965                970                975
Glu Pro Gly Asp Gly Gly Glu Lys Met Tyr Pro Tyr His Arg Asp Glu 
             980                985                990
Pro Pro Arg Ala Pro Trp Asn His Gly Glu Glu Arg Gly His Glu Glu 
         995                1000                1005
Phe Pro Leu Asp Gly Arg Asn Ala Pro Met Glu Arg Glu Arg Leu Asp 
     1010                1015                1020
Asp Trp Asp Arg Glu Arg Tyr Trp Arg Glu Cys Glu Arg Asp Tyr Gln 
 1025                1030                1035                1040
Asp Asp Thr Leu Glu Leu Tyr Asn Arg Glu Asp Arg Phe Ser Ala Pro 
                 1045                1050                1055
Pro Ser Arg Ser His Asp Gly Asp Arg Arg Gly Pro Trp Trp Asp Asp 
             1060                1065                1070
Trp Glu Arg Asp Gln Asp Met Asp Glu Asp Tyr Asn Arg Glu Met Glu 
         1075                1080                1085
Arg Asp Met Asp Arg Asp Val Asp Arg Ile Ser Arg Pro Met Asp Met 
     1090                1095                1100
Tyr Asp Arg Ser Leu Asp Asn Glu Trp Asp Arg Asp Tyr Gly Arg Pro 
 1105                1110                1115                1120
Leu Asp Glu Gln Glu Ser Gln Phe Arg Glu Arg Asp Ile Pro Ser Leu 
                 1125                1130                1135
Pro Pro Leu Pro Pro Leu Pro Pro Leu Pro Pro Leu Asp Arg Tyr Arg 
             1140                1145                1150
Asp Asp Arg Trp Arg Glu Glu Arg Asn Arg Glu His Gly Tyr Asp Arg 
         1155                1160                1165
Asp Phe Arg Asp Arg Gly Glu Leu Arg Ile Arg Glu Tyr Pro Glu Arg 
     1170                1175                1180
Gly Asp Thr Trp Arg Glu Lys Arg Asp Tyr Val Pro Asp Arg Met Asp 
 1185                1190                1195                1200
Trp Glu Arg Glu Arg Leu Ser Asp Arg Trp Tyr Pro Ser Asp Val Asp 
                 1205                1210                1215
Arg His Ser Pro Met Ala Glu His Met Pro Ser Ser His His Ser Ser 
             1220                1225                1230
Glu Met Met Gly Ser Asp Ala Ser Leu Asp Ser Asp Gln Gly Leu Gly 
         1235                1240                1245
Gly Val Met Val Leu Ser Gln Arg Gln His Glu Ile Ile Leu Lys Ala 
     1250                1255                1260
Ala Gln Glu Leu Lys Met Leu Arg Glu Gln Lys Glu Gln Leu Gln Lys 
 1265                1270                1275                1280
Met Lys Asp Phe Gly Ser Glu Pro Gln Met Ala Asp His Leu Pro Pro 
                 1285                1290                1295
Gln Glu Ser Arg Leu Gln Asn Thr Ser Ser Arg Pro Gly Met Tyr Pro 
             1300                1305                1310
Pro Pro Gly Ser Tyr Arg Pro Pro Pro Pro Met Gly Lys Pro Pro Gly 
         1315                1320                1325
Ser Ile Val Arg Pro Ser Ala Pro Pro Ala Arg Ser Ser Val Pro Val 
     1330                1335                1340
Thr Arg Pro Pro Val Pro Ile Pro Pro Pro Pro Pro Pro Pro Pro Leu 
 1345                1350                1355                1360
Pro Pro Pro Pro Pro Val Ile Lys Pro Gln Thr Ser Ala Val Glu Gln 
                 1365                1370                1375
Glu Arg Trp Asp Glu Asp Ser Phe Tyr Gly Leu Trp Asp Thr Asn Asp 
             1380                1385                1390
Glu Gln Gly Leu Asn Ser Glu Phe Lys Ser Glu Thr Ala Ala Ile Pro 
         1395                1400                1405
Ser Ala Pro Val Leu Pro Pro Pro Pro Val His Ser Ser Ile Pro Pro 
     1410                1415                1420
Pro Gly Pro Val Pro Met Gly Met Pro Pro Met Ser Lys Pro Pro Pro 
 1425                1430                1435                1440
Val Gln Gln Thr Val Asp Tyr Gly His Gly Arg Asp Ile Ser Thr Asn 
                 1445                1450                1455
Lys Val Glu Gln Ile Pro Tyr Gly Glu Arg Ile Thr Leu Arg Pro Asp 
             1460                1465                1470
Pro Leu Pro Glu Arg Ser Thr Phe Glu Thr Glu His Ala Gly Gln Arg 
         1475                1480                1485
Asp Arg Tyr Asp Arg Glu Arg Asp Arg Glu Pro Tyr Phe Asp Arg Gln 
     1490                1495                1500
Ser Asn Val Ile Ala Asp His Arg Asp Phe Lys Arg Asp Arg Glu Thr 
 1505                1510                1515                1520
His Arg Asp Arg Asp Arg Asp Arg Gly Val Ile Asp Tyr Asp Arg Asp 
                 1525                1530                1535
Arg Phe Asp Arg Glu Arg Arg Pro Arg Asp Asp Arg Ala Gln Ser Tyr 
             1540                1545                1550
Arg Asp Lys Lys Asp His Ser Ser Ser Arg Arg Gly Gly Phe Asp Arg 
         1555                1560                1565
Pro Ser Tyr Asp Arg Lys Ser Asp Arg Pro Val Tyr Glu Gly Pro Ser 
     1570                1575                1580
Met Phe Gly Gly Glu Arg Arg Thr Tyr Pro Glu Glu Arg Met Pro Leu 
 1585                1590                1595                1600
Pro Ala Pro Ser Leu Ser His Gln Pro Pro Pro Ala Pro Arg Val Glu 
                 1605                1610                1615
Lys Lys Pro Glu Ser Lys Asn Val Asp Asp Ile Leu Lys Pro Pro Gly 
             1620                1625                1630
Arg Glu Ser Arg Pro Glu Arg Ile Val Val Ile Met Arg Gly Leu Pro 
         1635                1640                1645
Gly Ser Gly Lys Thr His Val Ala Lys Leu Ile Arg Val Met Glu Tyr 
     1650                1655                1660
Glu Tyr Glu Ala Glu Met Glu Glu Thr Tyr Arg Thr Ser Met Phe Lys 
 1665                1670                1675                1680
Thr Phe Lys Lys Thr Leu Asp Asp Gly Phe Phe Pro Phe Ile Ile Leu 
                 1685                1690                1695
Asp Ala Ile Asn Asp Arg Val Arg His Phe Asp Gln Phe Trp Ser Ala 
             1700                1705                1710
Ala Lys Thr Lys Gly Phe Glu Val Tyr Leu Ala Glu Met Ser Ala Asp 
         1715                1720                1725
Asn Gln Thr Cys Gly Lys Arg Asn Ile His Gly Arg Lys Leu Lys Glu 
     1730                1735                1740
Ile Asn Lys Met Ala Asp His Trp Glu Thr Ala Pro Arg His Met Met 
 1745                1750                1755                1760
Arg Leu Asp Ile Arg Ser Leu Leu Gln Asp Ala Ala Ile Glu Glu Val 
                 1765                1770                1775
Glu Met Glu Asp Phe Asp Ala Asn Ile Glu Glu Gln Lys Glu Glu Lys 
             1780                1785                1790
Lys Asp Ala Glu Glu Glu Glu Ser Glu Leu Val Gly Asp Arg Pro Thr 
         1795                1800                1805
Thr Leu Asn Ser Val Ser Leu Leu Lys Phe Leu Lys Lys Val 
     1810                1815                1820



<210> 5188
<211> 530
<212> DNA
<213> Rattus norvegicus
<308> AA875019
<400> 5188

ttttttttt  tttttttgg  tttatagtg  aagtttatt  tttttaatc  aagtacaat  60
agctactag  tacatacag  aaaaaacaa  acggccacc  agcaatgat  atagtctgt  120
acaggtgca  aggagggaa  cttgttggg  gtcctgtgg  tccacacct  acttcagca  180
ttaagctga  cctccctcc  cagatcagt  aaaaaaaat  ttaacagtg  cttgcttgg  240
tagagcaag  ttctaaatt  tcttgggga  actggagaa  ttttaaaaa  gaaagtggt  300
aaacaagat  gaaacgtgg  gacacaaga  gcttcctga  aaagaagct  caggaggtc  360
tggcttcag  tcacctcaa  tcgaatcag  ttagaggag  gactccatt  aaaccaagg  420
tcatatgta  ttggtccgg  tgagggctc  ctcagccag  tggccgctc  catccgtga  480
cttctccca  tcagtctgc  cgaccacaa  acctatggc  cttcaacatc  530



<210> 5189
<211> 1386
<212> PRT
<213> Rattus norvegicus
<308> BAA85182
<400> 5189

Met Tyr Pro Asn Trp Gly Arg Tyr Gly Gly Ser Ser His Tyr Pro Pro 
  1               5                  10                  15
Pro Pro Val Pro Pro Pro Pro Pro Pro Val Ala Leu Pro Glu Ala Ser 
             20                  25                  30
Pro Gly Pro Gly Tyr Ser Ser Ser Thr Ala Pro Ala Ala Pro Ser Ser 
         35                  40                  45
Ser Gly Phe Met Ser Phe Arg Glu Gln His Leu Ala Gln Leu Gln Gln 
     50                  55                  60
Leu Gln Gln Met His Gln Lys Gln Met Gln Ser Val Leu Gln Pro His 
 65                  70                  75                  80
His Leu Pro Pro Pro Pro Leu Pro Pro Pro Pro Val Met Pro Gly Gly 
                 85                  90                  95
Gly Tyr Gly Asp Trp Gln Pro Pro Pro Pro Pro Met Pro Pro Pro Pro 
             100                105                110
Gly Pro Ala Leu Ser Tyr Gln Lys Gln Gln Gln Tyr Lys His Gln Met 
         115                120                125
Ile His His Gln Arg Asp Gly Pro Pro Gly Leu Val Pro Met Glu Leu 
     130                135                140
Glu Ser Pro Pro Glu Ser Pro Pro Val Pro Pro Gly Ser Tyr Met Pro 
 145                150                155                160
Pro Ser Gln Ser Tyr Met Pro Pro Pro Gln Pro Pro Pro Ser Tyr Tyr 
                 165                170                175
Pro Pro Ser Ser Ala Gln Pro Tyr Leu Pro Pro Ala Gln Pro Ser Pro 
             180                185                190
Ser Lys Pro Gln Leu Pro Pro Pro Pro Ser Ile Pro Ser Gly Asn Lys 
         195                200                205
Thr Ala Ile Gln Gln Glu Pro Leu Glu Ser Gly Ala Lys Asn Lys Thr 
     210                215                220
Ala Glu Gln Lys Gln Ala Ala Pro Glu Pro Asp Pro Ser Thr Met Thr 
 225                230                235                240
Pro Gln Glu Gln Gln Gln Tyr Trp Tyr Arg Gln His Leu Leu Ser Leu 
                 245                250                255
Gln Gln Arg Thr Lys Val His Leu Pro Gly His Lys Lys Gly Leu Val 
             260                265                270
Thr Ala Lys Asp Val Pro Glu Pro Ile Lys Glu Glu Ala Pro Gly Pro 
         275                280                285
Ala Ala Ser Gln Val Ala Glu Pro Leu Ala Ala Glu Lys Pro Pro Leu 
     290                295                300
Pro Pro Pro Asn Glu Glu Ala Pro Pro Pro Leu Ser Pro Glu Glu Pro 
 305                310                315                320
Gln Ser Glu Asp Ser Glu Asp Ser Glu Asp Ser Glu Glu Asp Ala Arg 
                 325                330                335
Phe Lys Gln Leu Lys Ala Ile Ala Ala His Trp Gln Ala Ala Ala Ala 
             340                345                350
His Trp Gln Gln Gln Gln Gln Gln Arg Val Gly Phe Gln Tyr Gln Gly 
         355                360                365
Ile Met Gln Arg His Thr Gln Leu Gln Gln Ile Leu Gln Gln Tyr Gln 
     370                375                380
Gln Val Ile Gln His Ser Pro His Ile Gln Thr Met Ser Leu Asp Val 
 385                390                395                400
Gln Leu Arg His Tyr Glu Met Gln Gln Gln Gln Phe Gln His Leu Phe 
                 405                410                415
Gln Asp Trp Glu Arg Glu Phe Gln Leu Trp Glu Glu Gln Leu His Ser 
             420                425                430
Tyr Pro His Lys Asp Gln Leu Gln Glu Tyr Glu Lys Gln Trp Lys Thr 
         435                440                445
Trp Gln Gly His Met Lys Ala Thr Gln Thr Tyr Leu Gln Glu Lys Val 
     450                455                460
Asn Ser Phe Gln Thr Val Lys Ser Gln Tyr Leu Gly Asn Met Ala Met 
 465                470                475                480
Pro Pro Pro Phe Val Pro Tyr Ser Gln Met Pro Pro Pro Leu Pro Thr 
                 485                490                495
Met Pro Pro Pro Val Leu Pro Pro Ser Leu Pro Pro Pro Val Met Pro 
             500                505                510
Pro Ala Leu Pro Thr Ser Ile Pro Pro Pro Gly Met Pro Pro Pro Val 
         515                520                525
Met Pro Pro Ser Leu Pro Thr Ser Val Pro Pro Pro Gly Met Pro Pro 
     530                535                540
Ser Leu Ser Ser Gly Pro Pro Pro Val Leu Pro Pro Pro Ala Leu Ser 
 545                550                555                560
Ser Ala Gly Ser Pro Pro Val Leu Pro Pro Pro Ala Leu Pro Gly Gly 
                 565                570                575
Pro Pro Ile Leu Pro Leu Pro Pro Leu Ser Ser Ala Thr Pro Pro Pro 
             580                585                590
Gly Ile Pro Pro Pro Gly Ala Pro Gln Gly Met Pro Pro Gln Leu Thr 
         595                600                605
Ala Pro Leu Pro Pro Ala Ser Gly Ser Gln Asn Ser Gln Ile Pro Glu 
     610                615                620
Lys Pro Arg Gln Ala Leu Leu Pro Thr Pro Val Ser Phe Gly Ser Thr 
 625                630                635                640
Pro Pro Ser Pro Tyr His Pro Pro Pro Gln Ser Glu Gln Val Asn Ser 
                 645                650                655
Lys Pro Leu Asn Lys Val Phe Ser Ser Glu Gln Gly Leu Gly Glu Ser 
             660                665                670
Ser Ala Leu Ser Gln Ser Ile Ile Ala Ala Lys Asp Thr Pro Val Lys 
         675                680                685
Ser Gly Gly Leu Leu Ala Asp Pro Pro Lys Gly Ser Phe Leu Glu Gly 
     690                695                700
Pro Arg Gly Pro Arg Glu Gln Lys Glu Gln Leu Gln Lys Leu Lys Asp 
 705                710                715                720
Phe Gly Ser Glu Pro Gln Met Ala Asp His Leu Pro Pro Pro Asp Ser 
                 725                730                735
Arg Leu Gln Asn Pro Ser Arg Pro Gly Met Tyr Pro Pro Pro Gly Ser 
             740                745                750
Tyr Arg Pro Pro Pro Pro Met Gly Lys Pro Pro Gly Ser Ile Val Arg 
         755                760                765
Pro Ser Ala Pro Pro Ala Arg Ser Ser Ile Pro Met Thr Arg Pro Pro 
     770                775                780
Val Pro Ile Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
 785                790                795                800
Pro Pro Val Ile Lys Ser Lys Thr Ser Ser Val Lys Gln Glu Arg Trp 
                 805                810                815
Asp Glu Asp Ser Phe Phe Gly Leu Trp Asp Thr Asn Asp Asp Gln Gly 
             820                825                830
Leu Asn Ser Glu Phe Lys Arg Asp Thr Ala Thr Ile Pro Ser Ala Pro 
         835                840                845
Val Leu Pro Pro Pro Pro Val His Ser Ser Ile Pro Pro Pro Gly Pro 
     850                855                860
Met Pro Met Gly Met Pro Pro Met Ser Lys Pro Pro Pro Val Gln His 
 865                870                875                880
Thr Val Asp Tyr Gly His Gly Arg Asp Met Pro Thr Asn Lys Val Glu 
                 885                890                895
Gln Ile Pro Tyr Gly Glu Arg Ile Thr Leu Arg Pro Asp Pro Leu Pro 
             900                905                910
Glu Arg Ser Thr Phe Asp Ala Asp His Ala Gly Gln Arg Asp Arg Tyr 
         915                920                925
Asp Arg Asp Arg Asp Arg Glu Pro Tyr Phe Asp Arg Pro Ser Asn Ile 
     930                935                940
Thr Asp His Arg Asp Phe Lys Arg Asp Arg Glu Thr His Arg Asp Arg 
 945                950                955                960
Asp Arg Asp Arg Val Leu Asp Tyr Glu Arg Asp Arg Phe Asp Arg Glu 
                 965                970                975
Arg Arg Pro Arg Asp Asp Arg Asn Gln Ser Tyr Arg Asp Lys Lys Asp 
             980                985                990
His Ser Ser Ser Arg Arg Gly Gly Phe Asp Arg Pro Ser Tyr Asp Arg 
         995                1000                1005
Lys Ser Asp Arg Pro Pro Tyr Glu Gly Pro Pro Met Phe Gly Gly Glu 
     1010                1015                1020
Arg Arg Thr Tyr Pro Glu Glu Arg Met Pro Leu Pro Ala Pro Ala Leu 
 1025                1030                1035                1040
Gly His Gln Pro Pro Pro Val Pro Arg Val Glu Lys Lys Pro Glu Ser 
                 1045                1050                1055
Lys Asn Val Asp Asp Ile Leu Lys Pro Pro Gly Arg Glu Ser Arg Pro 
             1060                1065                1070
Glu Arg Ile Val Val Ile Met Arg Gly Leu Pro Gly Ser Gly Lys Thr 
         1075                1080                1085
His Val Ala Lys Leu Ile Arg Asp Lys Glu Val Glu Phe Gly Gly Pro 
     1090                1095                1100
Ala Pro Arg Val Leu Ser Leu Asp Asp Tyr Phe Ile Ala Glu Val Glu 
 1105                1110                1115                1120
Lys Glu Glu Lys Asp Pro Asp Ser Gly Lys Lys Val Lys Lys Lys Val 
                 1125                1130                1135
Met Glu Tyr Glu Tyr Glu Ala Asp Met Glu Glu Thr Tyr Arg Thr Ser 
             1140                1145                1150
Met Phe Lys Thr Phe Lys Lys Thr Leu Asp Asp Gly Phe Phe Pro Phe 
         1155                1160                1165
Ile Ile Leu Asp Ala Ile Asn Asp Arg Val Arg His Phe Asp Gln Phe 
     1170                1175                1180
Trp Ser Ala Ala Lys Thr Lys Gly Phe Glu Val Tyr Leu Ala Glu Met 
 1185                1190                1195                1200
Ser Ala Asp Asn Gln Thr Cys Gly Lys Arg Asn Ile His Gly Arg Lys 
                 1205                1210                1215
Leu Lys Glu Ile Asn Lys Met Ala Glu His Trp Glu Val Ala Pro Arg 
             1220                1225                1230
His Met Met Arg Leu Asp Ile Arg Ser Leu Leu Gln Asp Ala Ala Ile 
         1235                1240                1245
Glu Glu Val Glu Met Glu Asp Phe Asp Ala Asn Ile Glu Asp Gln Lys 
     1250                1255                1260
Glu Glu Lys Lys Asp Ala Glu Glu Glu Glu Ser Glu Leu Gly Tyr Thr 
 1265                1270                1275                1280
Pro Lys Ser Lys Trp Glu Met Asp Thr Ser Glu Ala Lys Leu Asp Lys 
                 1285                1290                1295
Leu Asp Gly Leu Arg Thr Gly Thr Lys Arg Lys Arg Asp Trp Glu Ala 
             1300                1305                1310
Ile Ala Ser Arg Met Glu Asp Tyr Leu Gln Leu Pro Asp Asp Tyr Glu 
         1315                1320                1325
Thr Arg Ala Ser Glu Pro Gly Lys Lys Arg Val Arg Trp Ala Asp Leu 
     1330                1335                1340
Glu Glu Lys Lys Asp Ala Asp Arg Lys Arg Ala Ile Gly Phe Val Val 
 1345                1350                1355                1360
Gly Gln Thr Asp Trp Glu Lys Ile Thr Asp Glu Ser Gly His Leu Ala 
                 1365                1370                1375
Glu Arg Ala Leu Asn Arg Thr Lys Tyr Ile 
             1380                1385



<210> 5190
<211> 1601
<212> DNA
<213> Homo sapiens
<308> BC007792
<400> 5190

ttttgatag  ccatcctat  accggaagt  tgaccgacc  gtctatgaa  gaccatcca  60
gtttggagg  gaacgaagg  cttatcctg  ggagcgaat  cctctgcca  ctccttcac  120
gagccacca  cctcctcca  ctccacgag  cgagaagaa  cctgaatca  agaatgtgg  180
cgatatttt  aaaccaccg  gccgggaga  cagacctga  agaattgtt  ttataatga  240
aggattacc  ggcagtgga  agacacatg  tgcaaaact  attcgagat  aggaggtag  300
atttggagg  cctgcaccc  gagttctaa  cctggatga  tacttcatc  ctgaagtgg  360
aaaagaaga  aaagatcca  attctggaa  gaaagtgaa  aagaaggta  tggaatatg  420
atatgaagc  gagatggag  agacttacc  caccagcat  ttcaaaact  tcaaaaaga  480
tctggatga  ggctttttt  ccttcatca  cctggatgc  atcaatgac  gagttaggc  540
ttttgacca  ttttggagt  cagcaaaaa  caagggatt  gaggtatat  tggctgaaa  600
gagtgcaga  aaccagact  gtggcaaga  aaatattca  ggaagaaag  ttaaagaaa  660
aaataagat  gctgatcac  gggaaactg  acctcgtca  atgatgcgt  tagatattc  720
ttctttgct  caagatgct  ctattgaag  ggtagagat  gaagatttt  atgcaaata  780
cgaagaaca  aaagaagaa  agaaagatg  agaggaaga  gaaagcgaa  tgggttaca  840
tccgaaaag  aaatgggag  tggacacat  tgaggcaaa  ctagacaag  tggatggct  900
gaggactgg  actaaaagg  aacgtgact  ggaggccat  gccagcaga  tggaggatt  960
tcttcagct  cccgatgat  atgatactc  tgcttctga  cctgggaag  agagggtca  1020
atgggcaga  ctggaagag  agaaggatg  agataggaa  agggccata  gttttgtgg  1080
cggacagac  gattgggag  agatcacag  tgaaagtgg  cacctggct  aaaaagccc  1140
caatcgaac  aaatatata  gagacttag  ttttgaacg  agtcattat  cctctaagg  1200
ggttcgctt  gaggtggtc  gaagccaag  cctcgcgga  cttctttgt  tgtcacctt  1260
cttccacgt  tcagttctt  ttttgtttc  actgcttta  tttttttta  agttctcca  1320
tgtccccaa  aggtattag  atcttgctg  acccaagca  gacgttaat  tttctttta  1380
ctgttttgg  gagggaggg  gtgatagct  aactgctga  gccaggcgg  ggtctgctg  1440
aggattcca  cagagagta  ttcctccac  gtacaatgt  acagactat  tctatcatc  1500
ttgctttgt  gctgtttct  ttttttact  tatgtaact  gtagctgat  gtactagga  1560
taaaaacaa  aaactttca  gataaaaaa  aaaaaaaaa  a  1601



<210> 5191
<211> 1822
<212> PRT
<213> Homo sapiens
<308> P49750
<400> 5191

Met Tyr Pro Asn Trp Gly Arg Tyr Gly Gly Ser Ser His Tyr Pro Pro 
  1               5                  10                  15
Pro Pro Val Pro Pro Pro Pro Pro Val Ala Leu Pro Glu Ala Ser Pro 
             20                  25                  30
Gly Pro Gly Tyr Ser Ser Ser Thr Thr Pro Ala Ala Pro Ser Ser Ser 
         35                  40                  45
Gly Phe Met Ser Phe Arg Glu Gln His Leu Ala Gln Leu Gln Gln Leu 
     50                  55                  60
Gln Gln Met His Gln Lys Gln Met Gln Cys Val Leu Gln Pro His His 
 65                  70                  75                  80
Leu Pro Pro Pro Pro Leu Pro Pro Pro Pro Val Met Pro Gly Gly Gly 
                 85                  90                  95
Tyr Gly Asp Trp Gln Pro Pro Pro Pro Pro Met Pro Pro Pro Pro Gly 
             100                105                110
Pro Ala Leu Ser Tyr Gln Lys Gln Gln Gln Tyr Lys His Gln Met Leu 
         115                120                125
His His Gln Arg Asp Gly Pro Pro Gly Leu Val Pro Met Glu Leu Glu 
     130                135                140
Ser Pro Pro Glu Ser Pro Pro Val Pro Pro Gly Ser Tyr Met Pro Pro 
 145                150                155                160
Ser Gln Ser Tyr Met Pro Pro Pro Gln Pro Pro Pro Ser Tyr Tyr Pro 
                 165                170                175
Pro Thr Ser Ser Gln Pro Tyr Leu Pro Pro Ala Gln Pro Ser Pro Ser 
             180                185                190
Gln Ser Pro Pro Ser Gln Ser Tyr Leu Ala Pro Thr Pro Ser Tyr Ser 
         195                200                205
Ser Ser Ser Ser Ser Ser Gln Ser Tyr Leu Ser His Ser Gln Ser Tyr 
     210                215                220
Leu Pro Ser Ser Gln Ala Ser Pro Ser Arg Pro Ser Gln Gly His Ser 
 225                230                235                240
Lys Ser Gln Leu Leu Ala Pro Pro Pro Pro Ser Ala Pro Pro Gly Asn 
                 245                250                255
Lys Thr Thr Val Gln Gln Glu Pro Leu Glu Ser Gly Ala Lys Asn Lys 
             260                265                270
Ser Thr Glu Gln Gln Gln Ala Ala Pro Glu Pro Asp Pro Ser Thr Met 
         275                280                285
Thr Pro Gln Glu Gln Gln Gln Tyr Trp Tyr Arg Gln His Leu Leu Ser 
     290                295                300
Leu Gln Gln Arg Thr Lys Val His Leu Pro Gly His Lys Lys Gly Pro 
 305                310                315                320
Val Val Ala Lys Asp Thr Pro Glu Pro Val Lys Glu Glu Val Thr Val 
                 325                330                335
Pro Ala Thr Ser Gln Val Pro Glu Ser Pro Ser Ser Glu Glu Pro Pro 
             340                345                350
Leu Pro Pro Pro Asn Glu Glu Val Pro Pro Pro Leu Pro Pro Glu Glu 
         355                360                365
Pro Gln Ser Glu Asp Pro Glu Glu Asp Ala Arg Leu Lys Gln Leu Gln 
     370                375                380
Ala Ala Ala Ala His Trp Gln Gln His Gln Gln His Arg Val Gly Phe 
 385                390                395                400
Gln Tyr Gln Gly Ile Met Gln Lys His Thr Gln Leu Gln Gln Ile Leu 
                 405                410                415
Gln Gln Tyr Gln Gln Ile Ile Gln Pro Pro Pro His Ile Gln Ala Thr 
             420                425                430
Thr Pro Pro Pro Gly Ile Pro Pro Pro Gly Val Pro Gln Gly Ile Pro 
         435                440                445
Pro Gln Leu Thr Ala Ala Pro Val Pro Pro Ala Ser Ser Ser Gln Ser 
     450                455                460
Ser Gln Val Pro Glu Lys Pro Arg Pro Ala Leu Leu Pro Thr Pro Val 
 465                470                475                480
Ser Phe Gly Ser Ala Pro Pro Thr Thr Tyr His Pro Pro Leu Gln Ser 
                 485                490                495
Ala Gly Pro Ser Glu Gln Val Asn Ser Lys Ala Pro Leu Ser Lys Ser 
             500                505                510
Ala Leu Pro Tyr Ser Ser Phe Ser Ser Asp Gln Gly Leu Gly Glu Ser 
         515                520                525
Ser Ala Ala Pro Ser Gln Pro Ile Thr Ala Val Lys Asp Met Pro Val 
     530                535                540
Arg Ser Gly Gly Leu Leu Pro Asp Pro Pro Arg Ser Ser Tyr Leu Glu 
 545                550                555                560
Ser Pro Arg Gly Pro Arg Phe Asp Gly Pro Arg Arg Phe Glu Asp Leu 
                 565                570                575
Gly Ser Arg Cys Glu Gly Pro Arg Pro Lys Gly Pro Arg Phe Glu Gly 
             580                585                590
Asn Arg Pro Asp Gly Pro Arg Pro Arg Tyr Glu Gly His Pro Ala Glu 
         595                600                605
Gly Thr Lys Ser Lys Trp Gly Met Ile Pro Arg Gly Pro Ala Ser Gln 
     610                615                620
Phe Tyr Ile Thr Pro Ser Thr Ser Leu Ser Pro Arg Gln Ser Gly Pro 
 625                630                635                640
Gln Trp Lys Gly Pro Lys Pro Ala Phe Gly Gln Gln His Gln Gln Gln 
                 645                650                655
Pro Lys Ser Gln Ala Glu Pro Leu Ser Gly Asn Lys Glu Pro Leu Ala 
             660                665                670
Asp Thr Ser Ser Asn Gln Gln Lys Asn Phe Lys Met Gln Ser Ala Ala 
         675                680                685
Phe Ser Ile Ala Ala Asp Val Lys Asp Val Lys Ala Ala Gln Ser Asn 
     690                695                700
Glu Asn Leu Ser Asp Ser Gln Gln Glu Pro Pro Lys Ser Glu Val Ser 
 705                710                715                720
Glu Gly Pro Val Glu Pro Ser Asn Trp Asp Gln Asn Val Gln Ser Met 
                 725                730                735
Glu Thr Gln Ile Asp Lys Ala Gln Ala Val Thr Gln Pro Val Pro Leu 
             740                745                750
Ala Asn Lys Pro Val Pro Ala Gln Ser Thr Phe Pro Ser Lys Thr Gly 
         755                760                765
Gly Met Glu Gly Gly Thr Ala Val Ala Thr Ser Ser Leu Thr Ala Asp 
     770                775                780
Asn Asp Phe Lys Pro Val Gly Ile Gly Leu Pro His Ser Glu Asn Asn 
 785                790                795                800
Gln Asp Lys Gly Leu Pro Arg Pro Asp Asn Arg Asp Asn Arg Leu Glu 
                 805                810                815
Gly Asn Arg Gly Asn Ser Ser Ser Tyr Arg Gly Pro Gly Gln Ser Arg 
             820                825                830
Met Glu Asp Thr Arg Asp Lys Gly Leu Val Asn Arg Gly Arg Gly Gln 
         835                840                845
Ala Ile Ser Arg Gly Pro Gly Leu Val Lys Gln Glu Asp Phe Arg Asp 
     850                855                860
Lys Met Met Gly Arg Arg Glu Asp Ser Arg Glu Lys Met Asn Arg Gly 
 865                870                875                880
Glu Gly Ser Arg Asp Arg Gly Leu Val Arg Pro Gly Ser Ser Arg Glu 
                 885                890                895
Lys Val Pro Gly Gly Leu Gln Gly Ser Gln Asp Arg Gly Ala Ala Gly 
             900                905                910
Ser Arg Glu Arg Gly Pro Pro Arg Arg Ala Gly Ser Gln Glu Arg Gly 
         915                920                925
Pro Leu Arg Arg Ala Gly Ser Arg Glu Arg Ile Pro Pro Arg Arg Ala 
     930                935                940
Gly Ser Arg Glu Arg Gly Pro Pro Arg Gly Pro Gly Ser Arg Glu Arg 
 945                950                955                960
Gly Leu Gly Arg Ser Asp Phe Gly Arg Asp Arg Gly Pro Phe Arg Pro 
                 965                970                975
Glu Pro Gly Asp Gly Gly Glu Lys Met Tyr Pro Tyr His Arg Asp Glu 
             980                985                990
Pro Pro Arg Ala Pro Trp Asn His Gly Glu Glu Arg Gly His Glu Glu 
         995                1000                1005
Phe Pro Leu Asp Gly Arg Asn Ala Pro Met Glu Arg Glu Arg Leu Asp 
     1010                1015                1020
Asp Trp Asp Arg Glu Arg Tyr Trp Arg Glu Cys Glu Arg Asp Tyr Gln 
 1025                1030                1035                1040
Asp Asp Thr Leu Glu Leu Tyr Asn Arg Glu Asp Arg Phe Ser Ala Pro 
                 1045                1050                1055
Pro Ser Arg Ser His Asp Gly Asp Arg Arg Gly Pro Trp Trp Asp Asp 
             1060                1065                1070
Trp Glu Arg Asp Gln Asp Met Asp Glu Asp Tyr Asn Arg Glu Met Glu 
         1075                1080                1085
Arg Asp Met Asp Arg Asp Val Asp Arg Ile Ser Arg Pro Met Asp Met 
     1090                1095                1100
Tyr Asp Arg Ser Leu Asp Asn Glu Trp Asp Arg Asp Tyr Gly Arg Pro 
 1105                1110                1115                1120
Leu Asp Glu Gln Glu Ser Gln Phe Arg Glu Arg Asp Ile Pro Ser Leu 
                 1125                1130                1135
Pro Pro Leu Pro Pro Leu Pro Pro Leu Pro Pro Leu Asp Arg Tyr Arg 
             1140                1145                1150
Asp Asp Arg Trp Arg Glu Glu Arg Asn Arg Glu His Gly Tyr Asp Arg 
         1155                1160                1165
Asp Phe Arg Asp Arg Gly Glu Leu Arg Ile Arg Glu Tyr Pro Glu Arg 
     1170                1175                1180
Gly Asp Thr Trp Arg Glu Lys Arg Asp Tyr Val Pro Asp Arg Met Asp 
 1185                1190                1195                1200
Trp Glu Arg Glu Arg Leu Ser Asp Arg Trp Tyr Pro Ser Asp Val Asp 
                 1205                1210                1215
Arg His Ser Pro Met Ala Glu His Met Pro Ser Ser His His Ser Ser 
             1220                1225                1230
Glu Met Met Gly Ser Asp Ala Ser Leu Asp Ser Asp Gln Gly Leu Gly 
         1235                1240                1245
Gly Val Met Val Leu Ser Gln Arg Gln His Glu Ile Ile Leu Lys Ala 
     1250                1255                1260
Ala Gln Glu Leu Lys Met Leu Arg Glu Gln Lys Glu Gln Leu Gln Lys 
 1265                1270                1275                1280
Met Lys Asp Phe Gly Ser Glu Pro Gln Met Ala Asp His Leu Pro Pro 
                 1285                1290                1295
Gln Glu Ser Arg Leu Gln Asn Thr Ser Ser Arg Pro Gly Met Tyr Pro 
             1300                1305                1310
Pro Pro Gly Ser Tyr Arg Pro Pro Pro Pro Met Gly Lys Pro Pro Gly 
         1315                1320                1325
Ser Ile Val Arg Pro Ser Ala Pro Pro Ala Arg Ser Ser Val Pro Val 
     1330                1335                1340
Thr Arg Pro Pro Val Pro Ile Pro Pro Pro Pro Pro Pro Pro Pro Leu 
 1345                1350                1355                1360
Pro Pro Pro Pro Pro Val Ile Lys Pro Gln Thr Ser Ala Val Glu Gln 
                 1365                1370                1375
Glu Arg Trp Asp Glu Asp Ser Phe Tyr Gly Leu Trp Asp Thr Asn Asp 
             1380                1385                1390
Glu Gln Gly Leu Asn Ser Glu Phe Lys Ser Glu Thr Ala Ala Ile Pro 
         1395                1400                1405
Ser Ala Pro Val Leu Pro Pro Pro Pro Val His Ser Ser Ile Pro Pro 
     1410                1415                1420
Pro Gly Pro Val Pro Met Gly Met Pro Pro Met Ser Lys Pro Pro Pro 
 1425                1430                1435                1440
Val Gln Gln Thr Val Asp Tyr Gly His Gly Arg Asp Ile Ser Thr Asn 
                 1445                1450                1455
Lys Val Glu Gln Ile Pro Tyr Gly Glu Arg Ile Thr Leu Arg Pro Asp 
             1460                1465                1470
Pro Leu Pro Glu Arg Ser Thr Phe Glu Thr Glu His Ala Gly Gln Arg 
         1475                1480                1485
Asp Arg Tyr Asp Arg Glu Arg Asp Arg Glu Pro Tyr Phe Asp Arg Gln 
     1490                1495                1500
Ser Asn Val Ile Ala Asp His Arg Asp Phe Lys Arg Asp Arg Glu Thr 
 1505                1510                1515                1520
His Arg Asp Arg Asp Arg Asp Arg Gly Val Ile Asp Tyr Asp Arg Asp 
                 1525                1530                1535
Arg Phe Asp Arg Glu Arg Arg Pro Arg Asp Asp Arg Ala Gln Ser Tyr 
             1540                1545                1550
Arg Asp Lys Lys Asp His Ser Ser Ser Arg Arg Gly Gly Phe Asp Arg 
         1555                1560                1565
Pro Ser Tyr Asp Arg Lys Ser Asp Arg Pro Val Tyr Glu Gly Pro Ser 
     1570                1575                1580
Met Phe Gly Gly Glu Arg Arg Thr Tyr Pro Glu Glu Arg Met Pro Leu 
 1585                1590                1595                1600
Pro Ala Pro Ser Leu Ser His Gln Pro Pro Pro Ala Pro Arg Val Glu 
                 1605                1610                1615
Lys Lys Pro Glu Ser Lys Asn Val Asp Asp Ile Leu Lys Pro Pro Gly 
             1620                1625                1630
Arg Glu Ser Arg Pro Glu Arg Ile Val Val Ile Met Arg Gly Leu Pro 
         1635                1640                1645
Gly Ser Gly Lys Thr His Val Ala Lys Leu Ile Arg Val Met Glu Tyr 
     1650                1655                1660
Glu Tyr Glu Ala Glu Met Glu Glu Thr Tyr Arg Thr Ser Met Phe Lys 
 1665                1670                1675                1680
Thr Phe Lys Lys Thr Leu Asp Asp Gly Phe Phe Pro Phe Ile Ile Leu 
                 1685                1690                1695
Asp Ala Ile Asn Asp Arg Val Arg His Phe Asp Gln Phe Trp Ser Ala 
             1700                1705                1710
Ala Lys Thr Lys Gly Phe Glu Val Tyr Leu Ala Glu Met Ser Ala Asp 
         1715                1720                1725
Asn Gln Thr Cys Gly Lys Arg Asn Ile His Gly Arg Lys Leu Lys Glu 
     1730                1735                1740
Ile Asn Lys Met Ala Asp His Trp Glu Thr Ala Pro Arg His Met Met 
 1745                1750                1755                1760
Arg Leu Asp Ile Arg Ser Leu Leu Gln Asp Ala Ala Ile Glu Glu Val 
                 1765                1770                1775
Glu Met Glu Asp Phe Asp Ala Asn Ile Glu Glu Gln Lys Glu Glu Lys 
             1780                1785                1790
Lys Asp Ala Glu Glu Glu Glu Ser Glu Leu Val Gly Asp Arg Pro Thr 
         1795                1800                1805
Thr Leu Asn Ser Val Ser Leu Leu Lys Phe Leu Lys Lys Val 
     1810                1815                1820



<210> 5192
<211> 536
<212> DNA
<213> Rattus norvegicus
<308> AA875023
<400> 5192

ttttttttt  tttttttaa  atttttgta  tttattatt  ttagggaag  aacacagtt  60
cacaagaaa  aatgatttt  ctcaaacaa  agaaaaaag  tctttttga  aaaatccac  120
gtcctagat  aaaagtcta  ccagcaagc  ctgggccag  tttgagagt  aaaaccagt  180
aggtggaag  tacctatag  aaattcagt  cagaggtct  cacaagtcc  gatcagttc  240
gtaaggctc  aatgggcca  ctcggcggc  gcggcgaaa  agtgggaat  agctcacag  300
caaaggccc  gtccctctg  ctgactggg  tgcaggctg  ctcactccc  ggggggctg  360
atctgctta  agaactcat  aaactgctg  tgctccagc  ccgtcatga  tctgttgag  420
gcatagatc  ctgctcttt  tctttgctt  agctcctgc  gggcagatt  ctgtttaac  480
ttctccact  tgaaagcag  ttctttaac  ttggatttt  ctttccgcc  cgtgcc  536



<210> 5193
<211> 486
<212> DNA
<213> Rattus norvegicus
<308> AA875025
<400> 5193

ttttttttt  tttttttgc  tccaaacag  ttaatgact  gtacaatca  gcagatgcc  60
aaccaggga  gcgggaggc  acaagggcc  gaggggagg  tactacaac  ttgtcatag  120
gaaaatggg  ttgcctaat  ttcatgggg  agaggtgtg  ggaggaaag  cccactggc  180
gtgcgggac  acgacgtgc  cctcgtggg  acttgtatc  tgccatgaa  gcagaacaa  240
ctggccacc  ttactcccg  acataaatt  ttgtgcaca  cacatcatc  gcgccaaat  300
tcaggatta  ctcatcgtt  gccagctct  gggtccagt  agttttggg  ccatccccc  360
caagaagcg  ctgcgtgca  tgaatcttg  tctcattct  ccaagtggg  aaactcctg  420
acttgcgtc  gtccaccgt  tcctcctcg  agccctctc  gaccttgaa  ttgatccct  480
gtgccg  486



<210> 5194
<211> 137
<212> PRT
<213> Rattus norvegicus
<308> NP_038524
<400> 5194

Met Pro Asn Phe Ala Gly Thr Trp Lys Met Arg Ser Ser Glu Asn Phe 
  1               5                  10                  15
Asp Glu Leu Leu Lys Ala Leu Gly Val Asn Ala Met Leu Arg Lys Val 
             20                  25                  30
Ala Val Ala Ala Ala Ser Lys Pro His Val Glu Ile Arg Gln Asp Gly 
         35                  40                  45
Asp Gln Phe Tyr Ile Lys Thr Ser Thr Thr Val Arg Thr Thr Glu Ile 
     50                  55                  60
Asn Phe Lys Val Gly Glu Gly Phe Glu Glu Glu Thr Val Asp Gly Arg 
 65                  70                  75                  80
Lys Cys Arg Ser Leu Pro Thr Trp Glu Asn Glu Asn Lys Ile His Cys 
                 85                  90                  95
Thr Gln Thr Leu Leu Glu Gly Asp Gly Pro Lys Thr Tyr Trp Thr Arg 
             100                105                110
Glu Leu Ala Asn Asp Glu Leu Ile Leu Thr Phe Gly Ala Asp Asp Val 
         115                120                125
Val Cys Thr Arg Ile Tyr Val Arg Glu 
     130                135



<210> 5195
<211> 735
<212> DNA
<213> Homo sapiens
<308> S74445
<400> 5195

gagtctgcc  ttgcgagct  agagtgtgc  cgtgcgccg  cgccgtcgt  cctgccgcc  60
ccgccaccg  caccatgcc  aacttcgcc  gcacctgga  gatgcgcag  agcgagaat  120
tcgacgagc  gctgaaggc  ctgggtgtg  acgccatgc  gaggaaagt  gccgtagcg  180
ctgcgtcca  gccgcacgt  gagatccgc  aggacgggg  tcagttcta  atcaagaca  240
ccaccaccg  gcgcaccac  gagatcaac  tcaaggtcg  agaaggctt  gaggaggag  300
ccgtggacg  acgcaagtg  aggagttta  ccacttggg  gaatgagaa  aagatccac  360
gcacccaaa  tcttcttga  ggggacggc  ccaaaacct  ctggacccg  gagctggcc  420
acgatgaac  tatcctgac  tttggcgcc  atgacgtgg  ctgcaccag  atttatgtc  480
gggaatgaa  gcagctggc  tgctcctac  ttcaggaag  gatgcaggt  cccgaggaa  540
atgtcatag  tctgagctg  cagtggacc  cccttttcc  ctaccaata  taggtgatc  600
cgttttccc  atgacaatg  tgtagtgtc  cccaccccc  cccccctgg  cttggtgcc  660
cttgtatcc  tagtgctgc  tagcccggc  tttgcacgg  ttcgaagtc  ttaaactgg  720
tagacgtgt  tcaaa  735



<210> 5196
<211> 136
<212> PRT
<213> Homo sapiens
<308> P29762
<400> 5196

Pro Asn Phe Ala Gly Thr Trp Lys Met Arg Ser Ser Glu Asn Phe Asp 
  1               5                  10                  15
Glu Leu Leu Lys Ala Leu Gly Val Asn Ala Met Leu Arg Lys Val Ala 
             20                  25                  30
Val Ala Ala Ala Ser Lys Pro His Val Glu Ile Arg Gln Asp Gly Asp 
         35                  40                  45
Gln Phe Tyr Ile Lys Thr Ser Thr Thr Val Arg Thr Thr Glu Ile Asn 
     50                  55                  60
Phe Lys Val Gly Glu Gly Phe Glu Glu Glu Thr Val Asp Gly Arg Lys 
 65                  70                  75                  80
Cys Arg Ser Leu Ala Thr Trp Glu Asn Glu Asn Lys Ile His Cys Thr 
                 85                  90                  95
Gln Thr Leu Leu Glu Gly Asp Gly Pro Lys Thr Tyr Trp Thr Arg Glu 
             100                105                110
Leu Ala Asn Asp Glu Leu Ile Leu Thr Phe Gly Ala Asp Asp Val Val 
         115                120                125
Cys Thr Arg Ile Tyr Val Arg Glu 
     130                135



<210> 5197
<211> 439
<212> DNA
<213> Rattus norvegicus
<308> AA875033
<400> 5197

cggacgcaa  ggttttttt  tattttttt  cttcaaata  ttaatcagt  cggatacct  60
tgtcttcca  cccagttgg  taaaaactc  taagaaagc  tgattaaag  ggtcttcat  120
aaaactggg  taagacgca  ggaaggctg  ggttagaaa  actgaacat  acatgtatc  180
gaggccttc  ggaaggaat  ctatcactt  aaaaactca  aatgaacga  aaaaggtta  240
acactcata  aaattgtaa  aacaactaa  acttctctt  tgctgaaaa  accagacgt  300
attttaaaa  agactcttt  aaaaccttt  atcctgctg  gacgtgttc  catagcctt  360
tcagcacat  caagaagca  aatagctat  cccagcatt  cccatgagc  catgaggac  420
tttgcaaag  agcaatgca  439



<210> 5198
<211> 448
<212> PRT
<213> Rattus norvegicus
<308> Q9WVH8
<400> 5198

Met Pro Gly Leu Lys Arg Ile Leu Thr Val Thr Ile Leu Ala Leu Trp 
  1               5                  10                  15
Leu Pro His Pro Gly Asn Ala Gln Gln Gln Cys Thr Asn Gly Phe Asp 
             20                  25                  30
Leu Asp Arg Gln Thr Gly Gln Cys Leu Asp Ile Asp Glu Cys Arg Thr 
         35                  40                  45
Ile Pro Glu Ala Cys Arg Gly Asp Met Met Cys Val Asn Gln Asn Gly 
     50                  55                  60
Gly Tyr Leu Cys Ile Pro Arg Thr Asn Pro Val Tyr Arg Gly Pro Tyr 
 65                  70                  75                  80
Ser Asn Pro Tyr Ser Thr Ser Tyr Ser Gly Pro Tyr Pro Ala Ala Ala 
                 85                  90                  95
Pro Pro Val Pro Ala Ser Asn Tyr Pro Thr Ile Ser Arg Pro Leu Val 
             100                105                110
Cys Arg Phe Gly Tyr Gln Met Asp Glu Gly Asn Gln Cys Val Asp Val 
         115                120                125
Asp Glu Cys Ala Thr Asp Ser His Gln Cys Asn Pro Thr Gln Ile Cys 
     130                135                140
Ile Asn Thr Glu Gly Gly Tyr Thr Cys Ser Cys Thr Asp Gly Tyr Trp 
 145                150                155                160
Leu Leu Glu Gly Gln Cys Leu Asp Ile Asp Glu Cys Arg Tyr Gly Tyr 
                 165                170                175
Cys Gln Gln Leu Cys Ala Asn Val Pro Gly Ser Tyr Ser Cys Thr Cys 
             180                185                190
Asn Pro Gly Phe Thr Leu Asn Asp Asp Gly Arg Ser Cys Gln Asp Val 
         195                200                205
Asn Glu Cys Glu Thr Glu Asn Pro Cys Val Gln Thr Cys Val Asn Thr 
     210                215                220
Tyr Gly Ser Phe Ile Cys Arg Cys Asp Pro Gly Tyr Glu Leu Glu Glu 
 225                230                235                240
Asp Gly Ile His Cys Ser Asp Met Asp Glu Cys Ser Phe Ser Glu Phe 
                 245                250                255
Leu Cys Gln His Glu Cys Val Asn Gln Pro Gly Ser Tyr Phe Cys Ser 
             260                265                270
Cys Pro Pro Gly Tyr Val Leu Leu Glu Asp Asn Arg Ser Cys Gln Asp 
         275                280                285
Ile Asn Glu Cys Glu His Arg Asn His Thr Cys Thr Pro Leu Gln Thr 
     290                295                300
Cys Tyr Asn Leu Gln Gly Gly Phe Lys Cys Ile Asp Pro Ile Val Cys 
 305                310                315                320
Glu Glu Pro Tyr Leu Leu Ile Gly Asp Asn Arg Cys Met Cys Pro Ala 
                 325                330                335
Glu Asn Thr Gly Cys Arg Asp Gln Pro Phe Thr Ile Leu Phe Arg Asp 
             340                345                350
Met Asp Val Val Ser Gly Arg Ser Val Pro Ala Asp Ile Phe Gln Met 
         355                360                365
Gln Ala Thr Thr Arg Tyr Pro Gly Ala Tyr Tyr Ile Phe Gln Ile Lys 
     370                375                380
Ser Gly Asn Glu Gly Arg Glu Phe Tyr Met Arg Gln Thr Gly Pro Ile 
 385                390                395                400
Ser Ala Thr Leu Val Met Thr Arg Pro Ile Lys Gly Pro Arg Asp Ile 
                 405                410                415
Gln Leu Asp Leu Glu Met Ile Thr Val Asn Thr Val Ile Asn Phe Arg 
             420                425                430
Gly Ser Ser Val Ile Arg Leu Arg Ile Tyr Val Ser Gln Tyr Pro Phe 
         435                440                445



<210> 5199
<211> 2646
<212> DNA
<213> Homo sapiens
<308> NM_006329
<400> 5199

ttctgcccg  gcgctcgca  ccgagcgcg  ccggggaag  gctctcctc  cagcgccga  60
cactgggcc  tggcagacg  cccaagatt  ttgtgagga  tctagccag  tggtgagcg  120
tgtaatctg  accagctgt  tccagactg  ggccccatt  gcattgttt  acatactta  180
aaaatgaag  gttcatttt  aacattcct  ctccaattg  tttaatgct  aattactga  240
gagggctaa  caaaaccag  tgcttgcgc  gagggctct  cagtggctg  gaggacccc  300
gcgctctcc  cgtgtcctc  ccacgactc  ctcggcccc  ctggaataa  acacccgcg  360
gccccgagg  cccagagga  gccgacgtg  ccgagctcc  ccgggggtc  cgcccgcga  420
ctttcttct  gccttcgca  ctcctcctc  cgcgtcttg  acatgccag  aataaaaag  480
atactcact  ttaccattc  ggctctctg  cttccaagc  ctgggaatg  acaggcaca  540
tgcacgaat  gctttgacc  ggatcgcca  tcaggacag  gtttagata  tgatgaatg  600
cgaaccatc  ccgaggcct  ccgaggaga  atgatgtgt  ttaaccaaa  tggcgggta  660
ttatgcatt  cccggacaa  ccctgtgta  cgagggccc  actcgaacc  ctactcgac  720
ccctactca  gtccgtacc  agcagctgc  ccaccactc  cagctccaa  ctatcccac  780
atctccagg  ctcttatat  ccgctttgg  taccagatg  atgaaagca  ccaatgtgt  840
gatgtggac  agtgtgcaa  agattccca  cagtgcaac  ccacccaga  ctgcatcaa  900
actgaaggc  ggtacacct  ctcctgcac  gacggatat  ggcttctgg  aggccagtg  960
ttagacatt  atgaatgtc  ctatggtta  tgccagcag  tctgtgcga  tgttcctgg  1020
tcctattct  gtacatgca  ccctggttt  accctcaat  aggatggaa  gtcttgcca  1080
gatgtgaac  agtgtgcca  cgagaaccc  tgcgtgcaa  cctgcgtca  cacctacgg  1140
tctttcatc  gccgctgtg  cccaggata  gaacttgag  aagatggcg  tcattgcag  1200
gatatggac  agtgcagct  ctctgagtt  ctctgccaa  atgagtgtg  gaaccagcc  1260
ggcacatac  tctgctcct  ccctccagg  tacatcctg  tggatgaca  ccgaagctg  1320
caagacatc  acgaatgtg  gcacaggaa  cacacgtgc  acctgcagc  gacgtgcta  1380
aatttacaa  ggggcttca  atgcatcga  cccatccgc  gtgaggagc  ttatctgag  1440
atcagtgat  accgctgta  gtgtcctgc  gagaaccct  gctgcagag  ccagccctt  1500
accatcttg  accgggaca  ggacgtggt  tcaggacgc  ccgttcccg  tgacatctt  1560
caaatgcaa  ccacgaccc  ctaccctgg  gcctattac  ttttccaga  caaatctgg  1620
aatgagggc  gagaatttt  catgcggca  acgggcccc  tcagtgcca  cctggtgat  1680
acacgcccc  tcaaagggc  ccgggaaat  cagctggac  tggaaatga  cactgtcaa  1740
actgtcatc  acttcagag  cagctccgt  atccgactg  ggatatatg  gtcgcagta  1800
ccattctga  cctcgggct  gagcctccg  cgctgcctc  cattggcac  aagggacag  1860
agaagagag  aaataacag  gagaatgag  gcgacacag  cgttaggca  ttcctgctg  1920
acgtttccc  gaagagtca  ccccgactt  ctgactctc  cctgtacta  tgcagacct  1980
tcaccctgc  ggacttgcc  cccccagtt  ctatgacac  gttatcaaa  agtattatc  2040
ttgctcccc  gatagaaga  tgttggtga  ttttcaagg  cttcagttt  tttccacta  2100
tttcaaaga  aatagatta  gtttgcggg  gtctgagtc  atgttcaaa  actgtgaac  2160
gcttgctgt  acttcttca  ctcttccac  ccttctctc  ctgtgttac  gctttgcaa  2220
gacccggga  ctggcgggg  accctggga  tagctagtt  gctttttgc  tacacagag  2280
aggctatgt  aacaaacca  agcaggatc  aagggtttt  agagaatgt  tttcaaaac  2340
atgcctggt  ttttcaacc  taaaagaag  ttcagttgt  cttaaattt  tataacggt  2400
taattctgt  ttgttcatt  tgagtattt  taaaaaata  gtcgtagaa  tccttcgaa  2460
ggccttcag  cacatgcta  gttctgtct  cccaaaccc  gtctcctct  cattttagc  2520
cagtgtttt  tttgaggac  ccttaatct  gctttcttt  gaattttta  ccaattgga  2580
tggaatgca  aggtctcca  actgattaa  tatttgaag  gaaaaaaaa  aaaaaaaaa  2640
aaaaaa  2646



<210> 5200
<211> 448
<212> PRT
<213> Homo sapiens
<308> Q9UBX5
<400> 5200

Met Pro Gly Ile Lys Arg Ile Leu Thr Val Thr Ile Leu Ala Leu Cys 
  1               5                  10                  15
Leu Pro Ser Pro Gly Asn Ala Gln Ala Gln Cys Thr Asn Gly Phe Asp 
             20                  25                  30
Leu Asp Arg Gln Ser Gly Gln Cys Leu Asp Ile Asp Glu Cys Arg Thr 
         35                  40                  45
Ile Pro Glu Ala Cys Arg Gly Asp Met Met Cys Val Asn Gln Asn Gly 
     50                  55                  60
Gly Tyr Leu Cys Ile Pro Arg Thr Asn Pro Val Tyr Arg Gly Pro Tyr 
 65                  70                  75                  80
Ser Asn Pro Tyr Ser Thr Pro Tyr Ser Gly Pro Tyr Pro Ala Ala Ala 
                 85                  90                  95
Pro Pro Leu Ser Ala Pro Asn Tyr Pro Thr Ile Ser Arg Pro Leu Ile 
             100                105                110
Cys Arg Phe Gly Tyr Gln Met Asp Glu Ser Asn Gln Cys Val Asp Val 
         115                120                125
Asp Glu Cys Ala Thr Asp Ser His Gln Cys Asn Pro Thr Gln Ile Cys 
     130                135                140
Ile Asn Thr Glu Gly Gly Tyr Thr Cys Ser Cys Thr Asp Gly Tyr Trp 
 145                150                155                160
Leu Leu Glu Gly Gln Cys Leu Asp Ile Asp Glu Cys Arg Tyr Gly Tyr 
                 165                170                175
Cys Gln Gln Leu Cys Ala Asn Val Pro Gly Ser Tyr Ser Cys Thr Cys 
             180                185                190
Asn Pro Gly Phe Thr Leu Asn Glu Asp Gly Arg Ser Cys Gln Asp Val 
         195                200                205
Asn Glu Cys Ala Thr Glu Asn Pro Cys Val Gln Thr Cys Val Asn Thr 
     210                215                220
Tyr Gly Ser Phe Ile Cys Arg Cys Asp Pro Gly Tyr Glu Leu Glu Glu 
 225                230                235                240
Asp Gly Val His Cys Ser Asp Met Asp Glu Cys Ser Phe Ser Glu Phe 
                 245                250                255
Leu Cys Gln His Glu Cys Val Asn Gln Pro Gly Thr Tyr Phe Cys Ser 
             260                265                270
Cys Pro Pro Gly Tyr Ile Leu Leu Asp Asp Asn Arg Ser Cys Gln Asp 
         275                280                285
Ile Asn Glu Cys Glu His Arg Asn His Thr Cys Asn Leu Gln Gln Thr 
     290                295                300
Cys Tyr Asn Leu Gln Gly Gly Phe Lys Cys Ile Asp Pro Ile Arg Cys 
 305                310                315                320
Glu Glu Pro Tyr Leu Arg Ile Ser Asp Asn Arg Cys Met Cys Pro Ala 
                 325                330                335
Glu Asn Pro Gly Cys Arg Asp Gln Pro Phe Thr Ile Leu Tyr Arg Asp 
             340                345                350
Met Asp Val Val Ser Gly Arg Ser Val Pro Ala Asp Ile Phe Gln Met 
         355                360                365
Gln Ala Thr Thr Arg Tyr Pro Gly Ala Tyr Tyr Ile Phe Gln Ile Lys 
     370                375                380
Ser Gly Asn Glu Gly Arg Glu Phe Tyr Met Arg Gln Thr Gly Pro Ile 
 385                390                395                400
Ser Ala Thr Leu Val Met Thr Arg Pro Ile Lys Gly Pro Arg Glu Ile 
                 405                410                415
Gln Leu Asp Leu Glu Met Ile Thr Val Asn Thr Val Ile Asn Phe Arg 
             420                425                430
Gly Ser Ser Val Ile Arg Leu Arg Ile Tyr Val Ser Gln Tyr Pro Phe 
         435                440                445



<210> 5201
<211> 439
<212> DNA
<213> Rattus norvegicus
<308> AA875033
<400> 5201

cggacgcaa  ggttttttt  tattttttt  cttcaaata  ttaatcagt  cggatacct  60
tgtcttcca  cccagttgg  taaaaactc  taagaaagc  tgattaaag  ggtcttcat  120
aaaactggg  taagacgca  ggaaggctg  ggttagaaa  actgaacat  acatgtatc  180
gaggccttc  ggaaggaat  ctatcactt  aaaaactca  aatgaacga  aaaaggtta  240
acactcata  aaattgtaa  aacaactaa  acttctctt  tgctgaaaa  accagacgt  300
attttaaaa  agactcttt  aaaaccttt  atcctgctg  gacgtgttc  catagcctt  360
tcagcacat  caagaagca  aatagctat  cccagcatt  cccatgagc  catgaggac  420
tttgcaaag  agcaatgca  439



<210> 5202
<211> 448
<212> PRT
<213> Rattus norvegicus
<308> Q9WVH8
<400> 5202

Met Pro Gly Leu Lys Arg Ile Leu Thr Val Thr Ile Leu Ala Leu Trp 
  1               5                  10                  15
Leu Pro His Pro Gly Asn Ala Gln Gln Gln Cys Thr Asn Gly Phe Asp 
             20                  25                  30
Leu Asp Arg Gln Thr Gly Gln Cys Leu Asp Ile Asp Glu Cys Arg Thr 
         35                  40                  45
Ile Pro Glu Ala Cys Arg Gly Asp Met Met Cys Val Asn Gln Asn Gly 
     50                  55                  60
Gly Tyr Leu Cys Ile Pro Arg Thr Asn Pro Val Tyr Arg Gly Pro Tyr 
 65                  70                  75                  80
Ser Asn Pro Tyr Ser Thr Ser Tyr Ser Gly Pro Tyr Pro Ala Ala Ala 
                 85                  90                  95
Pro Pro Val Pro Ala Ser Asn Tyr Pro Thr Ile Ser Arg Pro Leu Val 
             100                105                110
Cys Arg Phe Gly Tyr Gln Met Asp Glu Gly Asn Gln Cys Val Asp Val 
         115                120                125
Asp Glu Cys Ala Thr Asp Ser His Gln Cys Asn Pro Thr Gln Ile Cys 
     130                135                140
Ile Asn Thr Glu Gly Gly Tyr Thr Cys Ser Cys Thr Asp Gly Tyr Trp 
 145                150                155                160
Leu Leu Glu Gly Gln Cys Leu Asp Ile Asp Glu Cys Arg Tyr Gly Tyr 
                 165                170                175
Cys Gln Gln Leu Cys Ala Asn Val Pro Gly Ser Tyr Ser Cys Thr Cys 
             180                185                190
Asn Pro Gly Phe Thr Leu Asn Asp Asp Gly Arg Ser Cys Gln Asp Val 
         195                200                205
Asn Glu Cys Glu Thr Glu Asn Pro Cys Val Gln Thr Cys Val Asn Thr 
     210                215                220
Tyr Gly Ser Phe Ile Cys Arg Cys Asp Pro Gly Tyr Glu Leu Glu Glu 
 225                230                235                240
Asp Gly Ile His Cys Ser Asp Met Asp Glu Cys Ser Phe Ser Glu Phe 
                 245                250                255
Leu Cys Gln His Glu Cys Val Asn Gln Pro Gly Ser Tyr Phe Cys Ser 
             260                265                270
Cys Pro Pro Gly Tyr Val Leu Leu Glu Asp Asn Arg Ser Cys Gln Asp 
         275                280                285
Ile Asn Glu Cys Glu His Arg Asn His Thr Cys Thr Pro Leu Gln Thr 
     290                295                300
Cys Tyr Asn Leu Gln Gly Gly Phe Lys Cys Ile Asp Pro Ile Val Cys 
 305                310                315                320
Glu Glu Pro Tyr Leu Leu Ile Gly Asp Asn Arg Cys Met Cys Pro Ala 
                 325                330                335
Glu Asn Thr Gly Cys Arg Asp Gln Pro Phe Thr Ile Leu Phe Arg Asp 
             340                345                350
Met Asp Val Val Ser Gly Arg Ser Val Pro Ala Asp Ile Phe Gln Met 
         355                360                365
Gln Ala Thr Thr Arg Tyr Pro Gly Ala Tyr Tyr Ile Phe Gln Ile Lys 
     370                375                380
Ser Gly Asn Glu Gly Arg Glu Phe Tyr Met Arg Gln Thr Gly Pro Ile 
 385                390                395                400
Ser Ala Thr Leu Val Met Thr Arg Pro Ile Lys Gly Pro Arg Asp Ile 
                 405                410                415
Gln Leu Asp Leu Glu Met Ile Thr Val Asn Thr Val Ile Asn Phe Arg 
             420                425                430
Gly Ser Ser Val Ile Arg Leu Arg Ile Tyr Val Ser Gln Tyr Pro Phe 
         435                440                445



<210> 5203
<211> 2646
<212> DNA
<213> Homo sapiens
<308> NM_006329
<400> 5203

ttctgcccg  gcgctcgca  ccgagcgcg  ccggggaag  gctctcctc  cagcgccga  60
cactgggcc  tggcagacg  cccaagatt  ttgtgagga  tctagccag  tggtgagcg  120
tgtaatctg  accagctgt  tccagactg  ggccccatt  gcattgttt  acatactta  180
aaaatgaag  gttcatttt  aacattcct  ctccaattg  tttaatgct  aattactga  240
gagggctaa  caaaaccag  tgcttgcgc  gagggctct  cagtggctg  gaggacccc  300
gcgctctcc  cgtgtcctc  ccacgactc  ctcggcccc  ctggaataa  acacccgcg  360
gccccgagg  cccagagga  gccgacgtg  ccgagctcc  ccgggggtc  cgcccgcga  420
ctttcttct  gccttcgca  ctcctcctc  cgcgtcttg  acatgccag  aataaaaag  480
atactcact  ttaccattc  ggctctctg  cttccaagc  ctgggaatg  acaggcaca  540
tgcacgaat  gctttgacc  ggatcgcca  tcaggacag  gtttagata  tgatgaatg  600
cgaaccatc  ccgaggcct  ccgaggaga  atgatgtgt  ttaaccaaa  tggcgggta  660
ttatgcatt  cccggacaa  ccctgtgta  cgagggccc  actcgaacc  ctactcgac  720
ccctactca  gtccgtacc  agcagctgc  ccaccactc  cagctccaa  ctatcccac  780
atctccagg  ctcttatat  ccgctttgg  taccagatg  atgaaagca  ccaatgtgt  840
gatgtggac  agtgtgcaa  agattccca  cagtgcaac  ccacccaga  ctgcatcaa  900
actgaaggc  ggtacacct  ctcctgcac  gacggatat  ggcttctgg  aggccagtg  960
ttagacatt  atgaatgtc  ctatggtta  tgccagcag  tctgtgcga  tgttcctgg  1020
tcctattct  gtacatgca  ccctggttt  accctcaat  aggatggaa  gtcttgcca  1080
gatgtgaac  agtgtgcca  cgagaaccc  tgcgtgcaa  cctgcgtca  cacctacgg  1140
tctttcatc  gccgctgtg  cccaggata  gaacttgag  aagatggcg  tcattgcag  1200
gatatggac  agtgcagct  ctctgagtt  ctctgccaa  atgagtgtg  gaaccagcc  1260
ggcacatac  tctgctcct  ccctccagg  tacatcctg  tggatgaca  ccgaagctg  1320
caagacatc  acgaatgtg  gcacaggaa  cacacgtgc  acctgcagc  gacgtgcta  1380
aatttacaa  ggggcttca  atgcatcga  cccatccgc  gtgaggagc  ttatctgag  1440
atcagtgat  accgctgta  gtgtcctgc  gagaaccct  gctgcagag  ccagccctt  1500
accatcttg  accgggaca  ggacgtggt  tcaggacgc  ccgttcccg  tgacatctt  1560
caaatgcaa  ccacgaccc  ctaccctgg  gcctattac  ttttccaga  caaatctgg  1620
aatgagggc  gagaatttt  catgcggca  acgggcccc  tcagtgcca  cctggtgat  1680
acacgcccc  tcaaagggc  ccgggaaat  cagctggac  tggaaatga  cactgtcaa  1740
actgtcatc  acttcagag  cagctccgt  atccgactg  ggatatatg  gtcgcagta  1800
ccattctga  cctcgggct  gagcctccg  cgctgcctc  cattggcac  aagggacag  1860
agaagagag  aaataacag  gagaatgag  gcgacacag  cgttaggca  ttcctgctg  1920
acgtttccc  gaagagtca  ccccgactt  ctgactctc  cctgtacta  tgcagacct  1980
tcaccctgc  ggacttgcc  cccccagtt  ctatgacac  gttatcaaa  agtattatc  2040
ttgctcccc  gatagaaga  tgttggtga  ttttcaagg  cttcagttt  tttccacta  2100
tttcaaaga  aatagatta  gtttgcggg  gtctgagtc  atgttcaaa  actgtgaac  2160
gcttgctgt  acttcttca  ctcttccac  ccttctctc  ctgtgttac  gctttgcaa  2220
gacccggga  ctggcgggg  accctggga  tagctagtt  gctttttgc  tacacagag  2280
aggctatgt  aacaaacca  agcaggatc  aagggtttt  agagaatgt  tttcaaaac  2340
atgcctggt  ttttcaacc  taaaagaag  ttcagttgt  cttaaattt  tataacggt  2400
taattctgt  ttgttcatt  tgagtattt  taaaaaata  gtcgtagaa  tccttcgaa  2460
ggccttcag  cacatgcta  gttctgtct  cccaaaccc  gtctcctct  cattttagc  2520
cagtgtttt  tttgaggac  ccttaatct  gctttcttt  gaattttta  ccaattgga  2580
tggaatgca  aggtctcca  actgattaa  tatttgaag  gaaaaaaaa  aaaaaaaaa  2640
aaaaaa  2646



<210> 5204
<211> 448
<212> PRT
<213> Homo sapiens
<308> Q9UBX5
<400> 5204

Met Pro Gly Ile Lys Arg Ile Leu Thr Val Thr Ile Leu Ala Leu Cys 
  1               5                  10                  15
Leu Pro Ser Pro Gly Asn Ala Gln Ala Gln Cys Thr Asn Gly Phe Asp 
             20                  25                  30
Leu Asp Arg Gln Ser Gly Gln Cys Leu Asp Ile Asp Glu Cys Arg Thr 
         35                  40                  45
Ile Pro Glu Ala Cys Arg Gly Asp Met Met Cys Val Asn Gln Asn Gly 
     50                  55                  60
Gly Tyr Leu Cys Ile Pro Arg Thr Asn Pro Val Tyr Arg Gly Pro Tyr 
 65                  70                  75                  80
Ser Asn Pro Tyr Ser Thr Pro Tyr Ser Gly Pro Tyr Pro Ala Ala Ala 
                 85                  90                  95
Pro Pro Leu Ser Ala Pro Asn Tyr Pro Thr Ile Ser Arg Pro Leu Ile 
             100                105                110
Cys Arg Phe Gly Tyr Gln Met Asp Glu Ser Asn Gln Cys Val Asp Val 
         115                120                125
Asp Glu Cys Ala Thr Asp Ser His Gln Cys Asn Pro Thr Gln Ile Cys 
     130                135                140
Ile Asn Thr Glu Gly Gly Tyr Thr Cys Ser Cys Thr Asp Gly Tyr Trp 
 145                150                155                160
Leu Leu Glu Gly Gln Cys Leu Asp Ile Asp Glu Cys Arg Tyr Gly Tyr 
                 165                170                175
Cys Gln Gln Leu Cys Ala Asn Val Pro Gly Ser Tyr Ser Cys Thr Cys 
             180                185                190
Asn Pro Gly Phe Thr Leu Asn Glu Asp Gly Arg Ser Cys Gln Asp Val 
         195                200                205
Asn Glu Cys Ala Thr Glu Asn Pro Cys Val Gln Thr Cys Val Asn Thr 
     210                215                220
Tyr Gly Ser Phe Ile Cys Arg Cys Asp Pro Gly Tyr Glu Leu Glu Glu 
 225                230                235                240
Asp Gly Val His Cys Ser Asp Met Asp Glu Cys Ser Phe Ser Glu Phe 
                 245                250                255
Leu Cys Gln His Glu Cys Val Asn Gln Pro Gly Thr Tyr Phe Cys Ser 
             260                265                270
Cys Pro Pro Gly Tyr Ile Leu Leu Asp Asp Asn Arg Ser Cys Gln Asp 
         275                280                285
Ile Asn Glu Cys Glu His Arg Asn His Thr Cys Asn Leu Gln Gln Thr 
     290                295                300
Cys Tyr Asn Leu Gln Gly Gly Phe Lys Cys Ile Asp Pro Ile Arg Cys 
 305                310                315                320
Glu Glu Pro Tyr Leu Arg Ile Ser Asp Asn Arg Cys Met Cys Pro Ala 
                 325                330                335
Glu Asn Pro Gly Cys Arg Asp Gln Pro Phe Thr Ile Leu Tyr Arg Asp 
             340                345                350
Met Asp Val Val Ser Gly Arg Ser Val Pro Ala Asp Ile Phe Gln Met 
         355                360                365
Gln Ala Thr Thr Arg Tyr Pro Gly Ala Tyr Tyr Ile Phe Gln Ile Lys 
     370                375                380
Ser Gly Asn Glu Gly Arg Glu Phe Tyr Met Arg Gln Thr Gly Pro Ile 
 385                390                395                400
Ser Ala Thr Leu Val Met Thr Arg Pro Ile Lys Gly Pro Arg Glu Ile 
                 405                410                415
Gln Leu Asp Leu Glu Met Ile Thr Val Asn Thr Val Ile Asn Phe Arg 
             420                425                430
Gly Ser Ser Val Ile Arg Leu Arg Ile Tyr Val Ser Gln Tyr Pro Phe 
         435                440                445



<210> 5205
<211> 551
<212> DNA
<213> Rattus norvegicus
<308> AA875037
<400> 5205

ttttttttt  tttttttcc  cttcttaaa  ttttattta  ttttttaaa  tttacttgt  60
tctgcataa  tttgagtga  gttacatgc  tatacagga  gctggggcc  gtagtagcc  120
aataaaggc  tcaagacat  ggtggaaac  ggaatttcc  gaggttgta  gcagccatg  180
gggtggtgg  aaatgtccc  gtgtccttt  caagatcag  aacttttcc  agtatctgt  240
cttctctcc  gcattctta  acattgatt  agttctacc  ggctgtaag  tattggcta  300
aagttatga  tatcagcgg  atagcaaag  ctatatggc  tcattagac  taacctgca  360
aagggcaca  atgcattca  gatagggag  gctgaatgc  ggcatcata  gatcaggct  420
gcaggaaga  agtatcctc  tcttggaac  tggtttccc  ctacttgcc  atcctgaca  480
agctttgga  tggtggaga  actgaagag  ggactctcc  catgtagta  atgtgtctt  540
atggagatg  g  551



<210> 5206
<211> 416
<212> PRT
<213> Rattus norvegicus
<308> S19896
<400> 5206

Met Glu Glu Leu Ser Met Ala Asn Thr Met Phe Ala Leu Asn Leu Leu 
  1               5                  10                  15
Lys Gln Ile Glu Gln Ser Asn Ser Thr Gln Asn Ile Phe Ile Ser Pro 
             20                  25                  30
Trp Ser Ile Ser Ser Thr Leu Ala Ile Val Phe Leu Gly Ala Gln Ala 
         35                  40                  45
Asn Thr Glu Glu Gln Met Ala Lys Val Leu Asn Phe Asp Lys Ile Gly 
     50                  55                  60
Ser Tyr Asp Leu Thr Pro Gly Asn Pro Glu Asn Phe His Gly Cys Asp 
 65                  70                  75                  80
Phe Ala Gln His Ile Gln Arg Asp Asn Tyr Pro Val Ala Ile Leu Gln 
                 85                  90                  95
Ala Gln Ala Arg Asp Lys Ile His Ser Ala Phe Ser Ser Leu Ser Ser 
             100                105                110
Thr Ile Asn Thr Pro Arg Leu Gly Asp Tyr Leu Leu Glu Ser Ala Asn 
         115                120                125
Lys Leu Phe Gly Glu Lys Ser Ala Arg Phe Lys Glu Glu Tyr Ile Gln 
     130                135                140
Arg Cys Lys Lys Tyr Tyr Ser Thr Glu Pro Glu Ala Val Asp Phe Leu 
 145                150                155                160
Glu Cys Ala Asn Glu Ala Arg Lys Lys Ile Asn Ser Trp Val Lys Thr 
                 165                170                175
Gln Thr Lys Gly Glu Ile Pro Asn Leu Leu Pro Glu Gly Ser Val Asp 
             180                185                190
Glu Asp Thr Lys Met Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Arg 
         195                200                205
Trp Lys Thr Pro Phe Gln Lys Arg Leu Asn Gly Leu Tyr Pro Phe Arg 
     210                215                220
Val Asn Leu Asn Glu Ser Lys Pro Val Gln Met Met Tyr Leu Arg Glu 
 225                230                235                240
Lys Leu Asn Ile Gly Tyr Ile Lys Asp Leu Lys Thr Gln Ile Leu Glu 
                 245                250                255
Leu Pro Tyr Ile Gly Asn Ile Ser Met Phe Leu Leu Leu Pro Asp Glu 
             260                265                270
Ile Glu Asp Ser Ser Thr Gly Leu Glu Met Leu Glu Arg Glu Ile Asn 
         275                280                285
Phe Asp Asn Phe Asn Lys Trp Ile Ser Lys Glu Thr Leu Asp Glu Asp 
     290                295                300
Asp Val Leu Val Tyr Ile Pro Lys Phe Lys Leu Ala Gln Asn Tyr Glu 
 305                310                315                320
Leu Lys Pro Ile Leu Gln Arg Met Gly Met Glu Asp Ala Phe Asn Lys 
                 325                330                335
Gly Lys Ala Asp Phe Ser Gly Met Ser Glu Ser Asn Asp Leu Phe Leu 
             340                345                350
Ser Glu Val Phe His Gln Ala Thr Val Asp Val Asn Glu Glu Gly Thr 
         355                360                365
Val Ala Ala Gly Gly Thr Gly Ala Val Met Thr Gly Arg Thr Gly His 
     370                375                380
Gly Gly Pro Gln Phe Val Ala Asp His Pro Phe Leu Phe Phe Ile Met 
 385                390                395                400
Asn Asn Ile Thr Arg Thr Ile Leu Phe Val Gly Arg Phe Ser Ser Pro 
                 405                410                415



<210> 5207
<211> 1385
<212> DNA
<213> Homo sapiens
<308> L40378
<400> 5207

cgcagcagc  gggccgggt  ctgcgcctc  ggggtcggc  tccaggctc  gagcgcggc  60
cggagacgg  ggcagcgct  gactaggtg  caggccctg  atcatggaa  ctctttcta  120
tgcaagtgg  acttttgcc  tacgccttt  aaagatact  tgtcaagat  acccttcgc  180
caacgtgtt  tgttctcct  tgagcatct  ctctgccct  gccatggtt  tcctagggg  240
aaagggaaa  accgcaacc  agatggccc  ggcactgtc  ttaaacaca  aggaagaca  300
tcatcgggc  ttccagtcg  ttctcactg  agtgaacaa  gctggcaca  agtacctgc  360
gagaacggc  aacaggctc  ttggagaga  aacttgtca  ttcctctca  cgtttaagg  420
atcctgtct  caattctac  atgctgagc  gaaggagct  tcctttatc  gagctgcag  480
agagtccag  aaacacatc  acacctggg  ctcaaaaaa  accgaaggt  aaattgaag  540
gttgttgcc  ggtagctca  ttgatgcag  aaccaggct  gttcttgtc  atgccatct  600
cttcaaagg  aagtggaat  aaccgtttg  cgaaacata  acaagggaa  tgcccttta  660
aataaacca  gaggagcaa  ggccagtgc  gatgatgta  caggaggcc  cgtttaagc  720
cgcccacgt  ggcgaggtg  gcgcgcagc  gctggagct  ccctacgcc  ggaaggagc  780
gagcctgct  gtgctgctg  ctgacgacg  cgtggagct  agcacggtg  aaaaaagtc  840
cacttttga  aaactcaca  cctggacca  gccagactg  atgaagagt  ctgaggttg  900
agttctcct  ccaaaattt  aactacaag  ggattatga  atggaatct  tgcttcggc  960
tttgggaat  gttgatgcc  tccaacagg  caaggctga  ttgtcggca  tgtcagcgg  1020
gagagacct  tgtctgtcc  agttcgtgc  caagagttt  gtggaggtg  atgaagaag  1080
caccgaggc  gcggcagcg  cgagctgct  tgtagttgc  gagtgctgc  tggaatctg  1140
ccccaggtt  tgtgctgac  accctttcc  tttcttcat  aggcacaac  gagccaaca  1200
cattctgtt  tgtggcagg  tctcatcgc  ataaagggt  cacttaccg  gcactcggc  1260
atttccctc  tcctgtgtc  ccagatccc  actacagct  caagaggat  ggcctagaa  1320
gccaagtgc  aagatgagg  cagattctt  acctgtctg  cctcatgat  tgccagcat  1380
aattc  1385



<210> 5208
<211> 376
<212> PRT
<213> Homo sapiens
<308> P50453
<400> 5208

Met Glu Thr Leu Ser Asn Ala Ser Gly Thr Phe Ala Ile Arg Leu Leu 
  1               5                  10                  15
Lys Ile Leu Cys Gln Asp Asn Pro Ser His Asn Val Phe Cys Ser Pro 
             20                  25                  30
Val Ser Ile Ser Ser Ala Leu Ala Met Val Leu Leu Gly Ala Lys Gly 
         35                  40                  45
Asn Thr Ala Thr Gln Met Ala Gln Ala Leu Ser Leu Asn Thr Glu Glu 
     50                  55                  60
Asp Ile His Arg Ala Phe Gln Ser Leu Leu Thr Glu Val Asn Lys Ala 
 65                  70                  75                  80
Gly Thr Gln Tyr Leu Leu Arg Thr Ala Asn Arg Leu Phe Gly Glu Lys 
                 85                  90                  95
Thr Cys Gln Phe Leu Ser Thr Phe Lys Glu Ser Cys Leu Gln Phe Tyr 
             100                105                110
His Ala Glu Leu Lys Glu Leu Ser Phe Ile Arg Ala Ala Glu Glu Ser 
         115                120                125
Arg Lys His Ile Asn Thr Trp Val Ser Lys Lys Thr Glu Gly Lys Ile 
     130                135                140
Glu Glu Leu Leu Pro Gly Ser Ser Ile Asp Ala Glu Thr Arg Leu Val 
 145                150                155                160
Leu Val Asn Ala Ile Tyr Phe Lys Gly Lys Trp Asn Glu Pro Phe Asp 
                 165                170                175
Glu Thr Tyr Thr Arg Glu Met Pro Phe Lys Ile Asn Gln Glu Glu Gln 
             180                185                190
Arg Pro Val Gln Met Met Tyr Gln Glu Ala Thr Phe Lys Leu Ala His 
         195                200                205
Val Gly Glu Val Arg Ala Gln Leu Leu Glu Leu Pro Tyr Ala Arg Lys 
     210                215                220
Glu Leu Ser Leu Leu Val Leu Leu Pro Asp Asp Gly Val Glu Leu Ser 
 225                230                235                240
Thr Val Glu Lys Ser Leu Thr Phe Glu Lys Leu Thr Ala Trp Thr Lys 
                 245                250                255
Pro Asp Cys Met Lys Ser Thr Glu Val Glu Val Leu Leu Pro Lys Phe 
             260                265                270
Lys Leu Gln Glu Asp Tyr Asp Met Glu Ser Val Leu Arg His Leu Gly 
         275                280                285
Ile Val Asp Ala Phe Gln Gln Gly Lys Ala Asp Leu Ser Ala Met Ser 
     290                295                300
Ala Glu Arg Asp Leu Cys Leu Ser Lys Phe Val His Lys Ser Phe Val 
 305                310                315                320
Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Ser Ser Cys Phe 
                 325                330                335
Val Val Ala Glu Cys Cys Met Glu Ser Gly Pro Arg Phe Cys Ala Asp 
             340                345                350
His Pro Phe Leu Phe Phe Ile Arg His Asn Arg Ala Asn Ser Ile Leu 
         355                360                365
Phe Cys Gly Arg Phe Ser Ser Pro 
     370                375



<210> 5209
<211> 539
<212> DNA
<213> Rattus norvegicus
<308> AA875040
<400> 5209

caggacagc  atttattta  aagcactgt  aacagtaca  gatacttca  aggtttaga  60
gttaatatg  gaaaaatac  aacagttca  gatactaaa  tcaactgtt  ctgaggcaa  120
gtggcttaa  aaggaaatc  agaaaccga  ttccaactc  aggcctctg  ctaagtcgt  180
ttcctagta  tgttcattc  attgcatcc  ctcaaacca  aagtgactt  ggaaacctc  240
ccgcagcag  tctggggtg  accgaagtc  gtgtagtcc  gtcaggtct  cacaaggaa  300
tggctttta  ccagcttcc  tctctcctt  aggtaggca  acaggtgcc  tctgcgtct  360
cacgtgacc  taatcccat  cttctcctc  ggggtgtcc  tgaccagaa  aggccccgg  420
tccggggtc  tgggggtcc  aggaccaag  atgcagcta  gaagactgt  ttccttctg  480
tctggggaa  agggatctt  tcttaccga  aaccctggg  ttcggatat  ggggggcat  539



<210> 5210
<211> 155
<212> PRT
<213> Rattus norvegicus
<308> AAH05726
<400> 5210

Arg Pro Thr Arg Arg Ser Thr Cys Lys Phe Pro Arg Leu Thr Phe Glu 
  1               5                  10                  15
Ser Pro Gln Ser Ser Ser Ser Glu Thr Leu Leu Leu Ser Asn Arg Val 
             20                  25                  30
Gln Pro Gln Asn Ser Glu Lys Asp Pro Pro Arg Arg Pro Leu Val Pro 
         35                  40                  45
Leu Phe Ser Pro Gln Ser Cys Gly Glu Leu Ser Val His Val Pro His 
     50                  55                  60
Ser Leu Pro His Val Phe Ala Pro Pro Asp Ile Gln Thr Pro Asp Ser 
 65                  70                  75                  80
Ser Val Arg Asp Asp Pro Ile Ser Pro Asp Gln Lys Glu Asn Ser Phe 
                 85                  90                  95
Pro Ser Cys Ile Leu Gly Pro Gly Thr Pro Ser Ser Pro Glu Pro Gly 
             100                105                110
Pro Val Leu Val Lys Asp Thr Pro Glu Glu Lys Tyr Gly Ile Lys Val 
         115                120                125
Thr Trp Arg Arg Arg Arg His Leu Phe Ala Tyr Leu Lys Glu Lys Gly 
     130                135                140
Lys Leu Asp Gly Ser Gln Phe Leu Val Lys Ile 
 145                150                155



<210> 5211
<211> 1426
<212> DNA
<213> Homo sapiens
<308> NM_031465
<400> 5211

cgaaggctg  gcggtctgc  aggagctgc  gccccgtcc  gcccgggct  gcatgggtt  60
gaattggag  ctatccccc  acccgaagg  taacagcat  atgtggtta  taactgttc  120
tcattcacc  gttgatgcc  cccagaaaa  aacgccgcc  gccttccca  aaagccccg  180
tgctgttcc  ccaacaacc  ctggagggc  ccaaacaca  ctgtgcatc  acacagctt  240
ccatcactc  cactcgaca  gtgcccagc  agcccattg  ccacagcac  atcacttcc  300
gggtatcac  tgattttga  acagcagca  gaagcttgt  cccagccta  cagaaacac  360
aaaaccggg  gagacactc  agtcgaaaa  ctaccacct  caagtttcc  catctaact  420
ttgagagtc  gcaatcttc  agttcagag  cattgggga  ccccttaat  cgagagtgc  480
ccagtgaat  agaaaagga  gtttccaga  gacccttag  tccagtgct  agtccccaa  540
gctgtggga  catgtcagt  caggcactt  agagcttac  ttatgtgtt  attccacct  600
atatccaga  cccagagtc  tcatctgtg  aggaagaac  cattcccca  gatcagaag  660
aaaacagcc  tctaagctg  actcttcac  ctggcactc  taatagccc  gagcctgga  720
ctgttctgg  taaagacac  cccgaggac  agtatggaa  aaaggtcac  tggaggaga  780
gacagcacc  gcttgctta  ctcagggag  gagggaagc  gagcagaag  caattcctt  840
tgaaaagct  actgccatc  gtaatctca  tagaaaaga  atatgtttt  tggagtcat  900
aaggaattc  attcctagg  tttttgttt  tgtttttga  atgtaatat  gctctgttg  960
ccaggctgg  gtgcagtgg  atgatctca  cttactgca  ccaccactt  ctgggttca  1020
gcgattctc  tgcctcagc  tccccagta  ctgggatta  aggcaccag  caccatgcc  1080
ggctaattt  tttgtattt  tagtagaga  gtggtttct  catgttggc  aggctggtc  1140
caaaatcct  acctcaagt  atctgctgg  cttgacctc  caaagtgct  gcccagccg  1200
gatttgttt  ctaagatac  ttgtgtcat  aacagttca  tttagtgtc  tgaactatt  1260
acttcatat  tttcttgta  taactgttt  aatttttaa  atatcttgt  gtaactctt  1320
aaaatgtat  taagtaaat  gctgcagaa  gttttttta  agaatcctg  ttccatcag  1380
aatacagca  tattacccc  tccactaaa  aaaaaaaaa  aaaaaa  1426



<210> 5212
<211> 238
<212> PRT
<213> Homo sapiens
<308> NP_113653
<400> 5212

Met Pro Pro Arg Lys Lys Arg Arg Gln Pro Ser Gln Lys Ala Pro Leu 
  1               5                  10                  15
Leu Phe His Gln Gln Pro Leu Glu Gly Pro Lys His Ser Cys Ala Ser 
             20                  25                  30
Thr Gln Leu Pro Ile Thr His Thr Arg Gln Val Pro Ser Lys Pro Ile 
         35                  40                  45
Asp His Ser Thr Ile Thr Ser Trp Val Ser Pro Asp Phe Asp Thr Ala 
     50                  55                  60
Ala Gly Ser Leu Phe Pro Ala Tyr Gln Lys His Gln Asn Arg Ala Arg 
 65                  70                  75                  80
His Ser Ser Arg Lys Pro Thr Thr Ser Lys Phe Pro His Leu Thr Phe 
                 85                  90                  95
Glu Ser Pro Gln Ser Ser Ser Ser Glu Thr Leu Gly Ile Pro Leu Ile 
             100                105                110
Arg Glu Cys Pro Ser Glu Ser Glu Lys Asp Val Ser Arg Arg Pro Leu 
         115                120                125
Val Pro Val Leu Ser Pro Gln Ser Cys Gly Asn Met Ser Val Gln Ala 
     130                135                140
Leu Gln Ser Leu Pro Tyr Val Phe Ile Pro Pro Asp Ile Gln Thr Pro 
 145                150                155                160
Glu Ser Ser Ser Val Lys Glu Glu Leu Ile Pro Gln Asp Gln Lys Glu 
                 165                170                175
Asn Ser Leu Leu Ser Cys Thr Leu His Thr Gly Thr Pro Asn Ser Pro 
             180                185                190
Glu Pro Gly Pro Val Leu Val Lys Asp Thr Pro Glu Asp Lys Tyr Gly 
         195                200                205
Ile Lys Val Thr Trp Arg Arg Arg Gln His Leu Leu Ala Tyr Leu Arg 
     210                215                220
Glu Arg Gly Lys Leu Ser Arg Ser Gln Phe Leu Val Lys Ser 
 225                230                235



<210> 5213
<211> 368
<212> DNA
<213> Rattus norvegicus
<308> AA875043
<400> 5213

ttttttttt  acacgtgca  attatttaa  aatatttca  taaaactgc  tggctggct  60
cgggccatc  atccactca  cggagcgcc  tcccctgac  catctctag  tcgggaagt  120
cttaaggaa  gtcaaagtc  tttctggag  cttctttac  cttcccaag  atagtttct  180
gagcagctt  caagcaagc  gcaggtcgc  agaccagaa  cagccctta  ctgggcgtg  240
ccaagagtg  gggagtgct  gaggaatag  agtcttgag  attggcagg  catacgtta  300
ggatgtaag  cacaaggtc  tgttgaagt  tccatttca  ttcagatgg  tcccatcat  360
aaacctga  368



<210> 5214
<211> 628
<212> PRT
<213> Rattus norvegicus
<308> Q63572
<400> 5214

Met Ala Gly Glu Arg Pro Pro Leu Arg Gly Pro Gly Pro Gly Glu Thr 
  1               5                  10                  15
Pro Val Glu Gly Pro Gly Gly Ala Gly Gly Gly Pro Gly Arg Gly Arg 
             20                  25                  30
Pro Ser Ser Tyr Arg Ala Leu Arg Ser Ala Val Ser Ser Leu Ala Arg 
         35                  40                  45
Val Asp Asp Phe Asp Cys Ala Glu Lys Ile Gly Ala Gly Phe Phe Ser 
     50                  55                  60
Glu Val Tyr Lys Val Arg His Arg Gln Ser Gly Gln Val Met Val Leu 
 65                  70                  75                  80
Lys Met Asn Lys Leu Pro Ser Asn Arg Ser Asn Thr Leu Arg Glu Val 
                 85                  90                  95
Gln Leu Met Asn Arg Leu Arg His Pro Asn Ile Leu Arg Phe Met Gly 
             100                105                110
Val Cys Val His Gln Gly Gln Leu His Ala Leu Thr Glu Tyr Met Asn 
         115                120                125
Gly Gly Thr Leu Glu Gln Leu Leu Ser Ser Pro Glu Pro Leu Ser Trp 
     130                135                140
Pro Val Arg Leu His Leu Ala Leu Asp Ile Ala Gln Gly Leu Arg Tyr 
 145                150                155                160
Leu His Ala Lys Gly Val Phe His Arg Asp Leu Thr Ser Lys Asn Cys 
                 165                170                175
Leu Val Arg Arg Glu Asp Gly Gly Phe Thr Ala Val Val Gly Asp Phe 
             180                185                190
Gly Leu Ala Glu Lys Ile Pro Val Tyr Arg Glu Gly Ala Arg Lys Glu 
         195                200                205
Pro Leu Ala Val Val Gly Ser Pro Tyr Trp Met Ala Pro Glu Val Leu 
     210                215                220
Arg Gly Glu Leu Tyr Asp Glu Lys Ala Asp Val Phe Ala Phe Gly Ile 
 225                230                235                240
Val Leu Cys Glu Leu Ile Ala Arg Val Pro Ala Asp Pro Asp Tyr Leu 
                 245                250                255
Pro Arg Thr Glu Asp Phe Gly Leu Asp Val Pro Ala Phe Arg Thr Leu 
             260                265                270
Val Gly Asn Asp Cys Pro Leu Pro Phe Leu Leu Leu Ala Ile His Cys 
         275                280                285
Cys Ser Met Glu Pro Ser Ala Arg Ala Pro Phe Thr Glu Ile Thr Gln 
     290                295                300
His Leu Glu Gln Ile Leu Glu Gln Leu Pro Glu Pro Thr Pro Leu Ala 
 305                310                315                320
Lys Met Pro Leu Ala Lys Ala Pro Leu Thr Tyr Asn Gln Gly Ser Val 
                 325                330                335
Pro Arg Gly Gly Pro Ser Ala Thr Leu Pro Arg Ser Asp Pro Arg Leu 
             340                345                350
Ser Arg Ser Arg Ser Asp Leu Phe Leu Pro Pro Ser Pro Glu Ser Pro 
         355                360                365
Pro Ser Trp Gly Asp Asn Leu Thr Arg Val Asn Pro Phe Ser Leu Arg 
     370                375                380
Glu Asp Leu Arg Gly Gly Lys Ile Lys Leu Leu Asp Thr Pro Cys Lys 
 385                390                395                400
Pro Ala Thr Pro Leu Pro Leu Val Pro Pro Ser Pro Leu Thr Ser Thr 
                 405                410                415
Gln Leu Pro Leu Val Ala Ser Pro Glu Ser Leu Val Gln Pro Glu Thr 
             420                425                430
Pro Val Arg Arg Cys Arg Ser Leu Pro Ser Ser Pro Glu Leu Pro Arg 
         435                440                445
Arg Met Glu Thr Ala Leu Pro Gly Pro Gly Pro Ser Pro Val Gly Pro 
     450                455                460
Ser Thr Glu Glu Arg Met Asp Cys Glu Gly Ser Ser Pro Glu Pro Glu 
 465                470                475                480
Pro Pro Gly Pro Ala Pro Gln Leu Pro Leu Ala Val Ala Thr Asp Asn 
                 485                490                495
Phe Ile Ser Thr Cys Ser Ser Ala Ser Gln Pro Trp Ser Ala Arg Pro 
             500                505                510
Gly Pro Ser Leu Asn Asn Asn Pro Pro Ala Val Val Val Asn Ser Pro 
         515                520                525
Gln Gly Trp Ala Arg Glu Pro Trp Asn Arg Ala Gln His Ser Leu Pro 
     530                535                540
Arg Ala Ala Ala Leu Glu Arg Thr Glu Pro Ser Pro Pro Pro Ser Ala 
 545                550                555                560
Pro Arg Glu Gln Glu Glu Gly Leu Pro Cys Pro Gly Cys Cys Leu Ser 
                 565                570                575
Pro Phe Ser Phe Gly Phe Leu Ser Met Cys Pro Arg Pro Thr Pro Ala 
             580                585                590
Val Ala Arg Tyr Arg Asn Leu Asn Cys Glu Ala Gly Ser Leu Leu Cys 
         595                600                605
His Arg Gly His His Ala Lys Pro Pro Thr Pro Ser Leu Gln Leu Pro 
     610                615                620
Gly Ala Arg Ser 
 625



<210> 5215
<211> 668
<212> DNA
<213> Homo sapiens
<308> AF479317
<400> 5215

caggaccng  cctcaataa  aatccccca  ctgtggtgg  gaactcccc  caaggctgg  60
ctggggagc  ctggaaccg  gcccagcat  gcctgcccc  ggcggcagc  ctggagcgg  120
cagaaccct  gccaccccc  tcagctccc  gggagcccg  tgaggggct  ccctgtcct  180
gctgctgcc  cagcccctt  agctttggc  tcctgtcca  gtgcccccg  cccacacca  240
ctgttgccc  ctaccgcaa  ctgaactgt  aggcgggca  tctcctctg  caccgaggg  300
accacgcca  gccacccac  cccagcctg  agctgcctg  ggcacgctc  tagcagtgg  360
gcccgtggt  tcaggcctc  aactttggc  ttcaggaca  cctgtaaga  cagagcaca  420
ttgctggac  gtgccagtt  cagatgggc  gaccggctc  tctccccgt  taggggagc  480
ccagcatgg  ctcaaggga  agagcactt  cagtcgacc  cccggctcg  gttcccgtg  540
ggatcactg  accagacac  gcattgctg  cacatgaga  taacacgtg  aattattta  600
aaagatttc  ataaaactg  ctggctggc  ccgggccgc  cctaaaaaa  aaaaaaaaa  660
aaaaaaaa  668



<210> 5216
<211> 626
<212> PRT
<213> Homo sapiens
<308> Q15569
<400> 5216

Met Ala Gly Glu Arg Pro Pro Leu Arg Gly Pro Gly Pro Gly Pro Gly 
  1               5                  10                  15
Glu Val Pro Gly Glu Gly Pro Pro Gly Pro Gly Gly Thr Gly Gly Gly 
             20                  25                  30
Pro Gly Arg Gly Arg Pro Ser Ser Tyr Arg Val Leu Arg Ser Ala Val 
         35                  40                  45
Ser Ser Leu Ala Arg Val Asp Asp Phe His Cys Ala Glu Lys Ile Gly 
     50                  55                  60
Ala Gly Phe Phe Ser Glu Val Tyr Lys Val Arg His Arg Gln Ser Gly 
 65                  70                  75                  80
Gln Val Met Val Leu Lys Met Asn Lys Leu Pro Ser Asn Arg Gly Asn 
                 85                  90                  95
Thr Leu Arg Glu Val Gln Leu Met Asn Arg Leu Arg His Pro Asn Ile 
             100                105                110
Leu Arg Phe Met Gly Val Cys Val His Gln Gly Gln Leu His Ala Leu 
         115                120                125
Thr Glu Tyr Met Asn Gly Gly Thr Leu Glu Gln Leu Leu Ser Ser Pro 
     130                135                140
Glu Pro Leu Ser Trp Pro Val Arg Leu His Leu Ala Leu Asp Ile Ala 
 145                150                155                160
Arg Gly Leu Arg Tyr Leu His Ser Lys Gly Val Phe His Arg Asp Leu 
                 165                170                175
Thr Ser Lys Asn Cys Leu Val Arg Arg Glu Asp Arg Gly Phe Thr Ala 
             180                185                190
Val Val Gly Asp Phe Gly Leu Ala Glu Lys Ile Pro Val Tyr Arg Glu 
         195                200                205
Gly Ala Arg Lys Glu Pro Leu Ala Val Val Gly Ser Pro Tyr Trp Met 
     210                215                220
Ala Pro Glu Val Leu Arg Gly Glu Leu Tyr Asp Glu Lys Ala Asp Val 
 225                230                235                240
Phe Ala Phe Gly Ile Val Leu Cys Glu Leu Ile Ala Arg Val Pro Ala 
                 245                250                255
Asp Pro Asp Tyr Leu Pro Arg Thr Glu Asp Phe Gly Leu Asp Val Pro 
             260                265                270
Ala Phe Arg Thr Leu Val Gly Asp Asp Cys Pro Leu Pro Phe Leu Leu 
         275                280                285
Leu Ala Ile His Cys Cys Asn Leu Glu Pro Ser Thr Arg Ala Pro Phe 
     290                295                300
Thr Glu Ile Thr Gln His Leu Glu Trp Ile Leu Glu Gln Leu Pro Glu 
 305                310                315                320
Pro Ala Pro Leu Thr Arg Thr Ala Leu Thr His Asn Gln Gly Ser Val 
                 325                330                335
Ala Arg Gly Gly Pro Ser Ala Thr Leu Pro Arg Pro Asp Pro Arg Leu 
             340                345                350
Ser Arg Ser Arg Ser Asp Leu Phe Leu Pro Pro Ser Pro Glu Ser Pro 
         355                360                365
Pro Asn Trp Gly Asp Asn Leu Thr Arg Val Asn Pro Phe Ser Leu Arg 
     370                375                380
Glu Asp Leu Arg Gly Gly Lys Ile Lys Leu Leu Asp Thr Pro Ser Lys 
 385                390                395                400
Pro Val Leu Pro Leu Val Pro Pro Ser Pro Phe Pro Ser Thr Gln Leu 
                 405                410                415
Pro Leu Val Thr Thr Pro Glu Thr Leu Val Gln Pro Gly Thr Pro Ala 
             420                425                430
Arg Arg Cys Arg Ser Leu Pro Ser Ser Pro Glu Leu Pro Arg Arg Met 
         435                440                445
Glu Thr Ala Leu Pro Gly Pro Gly Pro Pro Ala Val Gly Pro Ser Ala 
     450                455                460
Glu Glu Lys Met Glu Cys Glu Gly Ser Ser Pro Glu Pro Glu Pro Pro 
 465                470                475                480
Gly Pro Ala Pro Gln Leu Pro Leu Ala Val Ala Thr Asp Asn Phe Ile 
                 485                490                495
Ser Thr Cys Ser Ser Ala Ser Gln Pro Trp Ser Pro Arg Ser Gly Pro 
             500                505                510
Val Leu Asn Asn Asn Pro Pro Ala Val Val Val Asn Ser Pro Gln Gly 
         515                520                525
Trp Ala Gly Glu Pro Trp Asn Arg Ala Gln His Ser Leu Pro Arg Ala 
     530                535                540
Ala Ala Leu Glu Arg Thr Glu Pro Ser Pro Pro Pro Ser Ala Pro Arg 
 545                550                555                560
Glu Pro Asp Glu Gly Leu Pro Cys Pro Gly Cys Cys Leu Gly Pro Phe 
                 565                570                575
Ser Phe Gly Phe Leu Ser Met Cys Pro Arg Pro Thr Pro Ala Val Ala 
             580                585                590
Arg Tyr Arg Asn Leu Asn Cys Glu Ala Gly Ser Leu Leu Cys His Arg 
         595                600                605
Gly His His Ala Lys Pro Pro Thr Pro Ser Leu Gln Leu Pro Gly Ala 
     610                615                620
Arg Ser 
 625



<210> 5217
<211> 547
<212> DNA
<213> Rattus norvegicus
<308> AA875050
<400> 5217

ttttttttt  tttttttcc  agaaacaaa  attttaatg  agaaaacca  gataatcta  60
aaatgaatc  cagtggagg  ctataccgg  ccccctcag  aactgtaag  actgggacg  120
ggacactga  ctgacaaca  cgtcagcat  tggacatgc  caggcagct  tgctggcct  180
acggcacct  ggccttgcc  ccttgcctt  caccattca  tccccaatg  gaagaccag  240
agttaagtt  agaatagaa  ggggagagg  ggaggatgc  gctggctct  gtacctgcc  300
catgactca  ggccaggcc  actcccagg  ctctgtccc  ctcctctgc  gggacctag  360
aggaacacg  ggaggggac  tagggaagg  gtggctgga  ggcatctgg  ttggagaag  420
tggcagcct  agataaggc  gctgctgga  gaactgtca  gtgcagctg  gacctctcc  480
cccaagatg  cagctgaat  ggcttcctg  tggcttgga  ctcagcacc  ctcactggg  540
catacat  547



<210> 5218
<211> 394
<212> PRT
<213> Rattus norvegicus
<308> O54783
<400> 5218

Met Ala Ala Asp Gly Thr Gly Val Val Gly Gly Gly Ala Val Gly Gly 
  1               5                  10                  15
Pro Leu Ser Lys Asp Gly Leu Leu Asp Ala Lys Cys Pro Glu Pro Ile 
             20                  25                  30
Pro Asn Arg Arg Arg Ser Ser Ser Leu Ser Arg Asp Ala Gln Arg Arg 
         35                  40                  45
Ala Tyr Gln Trp Cys Arg Glu Tyr Leu Gly Gly Ala Trp Arg Arg Ala 
     50                  55                  60
Arg Pro Glu Glu Leu Ser Val Cys Pro Val Ser Gly Gly Leu Ser Asn 
 65                  70                  75                  80
Leu Leu Phe Arg Cys Ser Leu Pro Asn His Val Pro Ser Met Gly Gly 
                 85                  90                  95
Glu Pro Arg Glu Val Leu Leu Arg Leu Tyr Gly Ala Ile Leu Gln Gly 
             100                105                110
Val Asp Ser Leu Val Leu Glu Ser Val Met Phe Ala Ile Leu Ala Glu 
         115                120                125
Arg Ser Leu Gly Pro Gln Leu Tyr Gly Val Phe Pro Glu Gly Arg Leu 
     130                135                140
Glu Gln Tyr Leu Pro Ser Arg Pro Leu Lys Thr Gln Glu Leu Arg Asp 
 145                150                155                160
Pro Val Leu Ser Gly Ala Ile Ala Thr Lys Met Ala Arg Phe His Gly 
                 165                170                175
Met Glu Met Pro Phe Thr Lys Glu Pro Arg Trp Leu Phe Gly Thr Met 
             180                185                190
Glu Arg Tyr Leu Lys Gln Ile Gln Asp Leu Pro Ser Thr Ser Leu Pro 
         195                200                205
Gln Met Asn Leu Val Glu Met Tyr Ser Leu Lys Asp Glu Met Asn His 
     210                215                220
Leu Arg Thr Leu Leu Asp Ala Thr Pro Ser Pro Val Val Phe Cys His 
 225                230                235                240
Asn Asp Ile Gln Glu Gly Asn Ile Leu Leu Leu Ser Glu Pro Asp Ser 
                 245                250                255
Asp Asp Asn Leu Met Leu Val Asp Phe Glu Tyr Ser Ser Tyr Asn Tyr 
             260                265                270
Arg Gly Phe Asp Ile Gly Asn His Phe Cys Glu Trp Val Tyr Asp Tyr 
         275                280                285
Thr Tyr Glu Glu Trp Pro Phe Tyr Lys Ala Arg Pro Ala Asp Tyr Pro 
     290                295                300
Thr Arg Glu Gln Gln Leu Leu Phe Ile Arg His Tyr Leu Ala Glu Val 
 305                310                315                320
Gln Lys Gly Glu Val Leu Ser Glu Glu Glu Gln Lys Lys Gln Glu Glu 
                 325                330                335
Asp Leu Leu Ile Glu Ile Ser Arg Tyr Ala Leu Ala Ser His Phe Phe 
             340                345                350
Trp Gly Leu Trp Ser Thr Leu Gln Ala Ser Met Ser Thr Ile Glu Phe 
         355                360                365
Gly Tyr Leu Glu Tyr Ala Gln Ser Arg Phe Gln Phe Tyr Phe Gln Gln 
     370                375                380
Lys Gly Gln Leu Thr Ser Phe Leu Ser Pro 
 385                390



<210> 5219
<211> 4025
<212> DNA
<213> Homo sapiens
<308> AB029885
<400> 5219

ggaattcgg  cttcggaaa  agcccccgg  ccggggcac  gagagagcc  agcgccgca  60
ccgtgagcc  aatagagcc  gagagaccc  agtatgacc  gagaagccc  ggccggccg  120
aagaggagc  gagcgcggc  ggaaggaac  gagcccgtc  gaagggagc  gagcgcagc  180
tggcctggg  cccggtcga  cccgcgcca  ggcggccga  gcgacagct  tggccggaa  240
cggggctgt  ggcggctgc  tggccaaag  cggcttgca  cagtctaag  gcccggaca  300
taccccaaa  cggcggcgc  cctcgtcgc  gtcgcgtga  gccgagcgc  gagcctacc  360
atggtgccg  gagtacttg  gcggggcct  gcgccgagt  cagcccgag  agctgaggg  420
ttaccccgt  aggtgggag  tcaggggtc  gcctctccg  tgcgcggat  ggggtcagg  480
gtcagccgc  gggccctca  gatgctcca  gttttcgcc  ccctcttgc  cccgcgcct  540
gggcggggc  gggccggcc  ggccgggag  gggccgggg  cgcggcagg  agggccggc  600
gcgggctga  cgcgcctgg  gtgggtctg  agcggaggc  tcagcaacc  gctcttccg  660
tgctcgctc  cggaccacc  gcccagcgt  ggcgaggag  cccgggagg  gcttctgcg  720
ctgtacgga  ccatcttgc  ggtgagggg  gtgtgagcg  cgcagcacc  gtggcttta  780
ggcctgtcg  ttacgcgat  cgggtagta  tgttcccgt  gcgcagttg  ggacaccga  840
gttcacggt  tgagtaaca  ctcattaca  cgaagcctg  gcctgtatt  ccagagctt  900
gggaggctg  ggcgagagg  tcacttgag  acaggagtt  gagaccagc  tggacaaca  960
agtgagacc  ccatctcta  ataaaaata  accaacgct  aagcctgtg  tccagagcc  1020
ccaggcaat  ggatcagaa  tcgcagctc  ggtgggagg  aggcgagcc  tcatgtgtg  1080
ccctgtgcc  ctttgcctt  gcccctttg  tgtccatcc  ttttcaggg  gtggactcc  1140
tggtgctag  aagcgtgat  ttcgccata  ttgcggagc  gtcgctggg  ccccagctg  1200
acggagtct  cccagaggg  cggctggaa  agtacatcc  agtacgggc  cagtcctac  1260
ctctcctcc  caaggcacc  ccaccccct  accctaccc  agtgcccaa  gtctgcctc  1320
acatccctc  ccccaagta  ggaatttcc  ccaaaaccc  gacttcccc  cattgcccc  1380
gcccttccc  ctcctgccc  agccccatc  ccaccctga  agcttcctg  gtgcagagt  1440
ggccattga  aactcaaga  cttcgagag  cagtgttgt  agcagccat  gccacgaag  1500
tggcgcaat  tcatggcat  gagatgcct  tcaccaagg  gccccactg  ctgtttggg  1560
ccatggagc  gtgagtcag  agcctcctc  gggctcctg  actcctgag  tgaacctcc  1620
tgccagcgg  tgtgtcggg  gctctatcc  gccctccac  tgagtggat  tgatgtcat  1680
ggctgtcac  gaacaggct  ttaaatgct  gccagaggc  acatgcagt  cctcatgcc  1740
gtaatccca  aactttggg  gccgaggtg  gtgaggtgg  aggatcact  gagcccagg  1800
ggcggaggt  gcagtgagc  gagctcatg  cattgcact  cagcctggg  gagagcaag  1860
ctctgtctc  aaacaccaa  caaaaaaag  aaaaagaaa  gattgccaa  gccaggcac  1920
gtggctcat  cctgtaatc  tagcacttc  ggaggctga  gtgagcaga  tgcctgagc  1980
caggagttc  aaaccagcc  ggacaacac  gtgaaaccc  gtctctatt  aaatacaaa  2040
aaattagcc  ggcatggca  catgcacct  tagtcccag  tactcggga  gctgaggca  2100
gagaattgc  tgaacccgg  aggcagagg  tgcagtgag  caagatcgc  ccactgcac  2160
ccagcctgg  tgacagagc  agactccat  tcaaaagaa  aaaagaaat  attgccgga  2220
aagtcacac  gtgatagga  caggggtgc  gtagtctgg  ctgaggggt  gataggcga  2280
gggtgggaa  gaatagcag  gccagtgta  cctattctt  gggcttcag  tacctaaaa  2340
agatccagg  cctgccccc  actggcctc  ctgagatga  cctgctgga  atgtacagc  2400
tgaaggatg  gatgggcaa  ctcaggtga  ggcaggcag  acaaggcta  tggtaatgg  2460
gtccgccct  ccagtagtt  ctgagggct  gtgtcaggg  ctggcctgt  agggtggct  2520
tgatcctcc  ctagtcact  ctgctcagg  cccatgctc  catacccct  taggaagtt  2580
ctagagtct  ccccatcgc  agtcgtctt  tgccacaat  acatccagg  aggtaggag  2640
aggcatctg  gtctcctaa  ccaagatgg  agagccaga  ggctctgga  tgagcagaa  2700
ctcacccca  tcccccagg  aacatcttg  tgctctcag  gccagaaaa  gctgacagc  2760
tcatgctgg  ggacttcga  tacagcagt  ataactata  gtgaggctg  aaagatggc  2820
tcccataga  ctgttccca  agggctctt  aaaacaggc  agctgccca  ggcatttgg  2880
gactgaatg  ccaccttat  ctcccaggg  ctttgacat  gggaaccat  tttgtgagt  2940
ggtttatga  tatactcac  aggaatggc  tttctacaa  gcaaggccc  cagactacc  3000
cactcaaga  cagcaggta  gtgggccag  ggctgggga  caggaccca  cctgtgagg  3060
aggagggag  tggagtctg  aaggaatgg  cggaaagga  gttacctgg  aaatactcc  3120
cagtctccc  aattcctga  tcttggcca  tgatcgtag  tgcatttta  tcgtcatta  3180
ctggcagag  caaagaaag  tgagaccct  tcccaagag  agcagagaa  actggaaga  3240
gatttgctg  tagaagtca  tcggtgagg  aggaggggc  gggtggggt  gggcagagc  3300
gaggaaaga  ggattgggg  agaggcaga  ttatcaagc  gcagggaag  tggctgtgg  3360
gagtggagt  aggacagtg  gggagaagt  aaaactgta  ggattggcc  acctgggtg  3420
ggggatcca  gcagtgcta  acatgctct  gaatgcccc  ccttttcct  ccctccccc  3480
aggtatgct  tggcatccc  tttcttctg  ggtctgtgg  ccatcctcc  ggcatccat  3540
tccaccata  aatttggtt  cttggtaag  gaccctggg  atgggaatg  tagctgggg  3600
gctggggag  agcagcagc  acactcttc  aggaggcct  gggagtccc  ggtggctgt  3660
ggcagctga  gtggatgta  aatgctggt  ccacgtctt  tcaccactg  gtgggtggg  3720
ttccttccc  aggactatg  ccagtctcg  ttccagttc  acttccagc  gaaggggca  3780
ctgaccagt  tccactcct  atcctgact  caccctccc  ctccttgga  ttctcctgg  3840
gcctccagg  caggacctt  gagggagga  caacgagca  aaggccctg  cgactgggc  3900
gagccccca  gtgaaactg  ggttcagga  accggcctg  tcctgagtt  gagtaggtc  3960
ccatggctg  caggccaga  ccccgtgct  tgtatgtaa  acaataaac  agcttcttc  4020
tccca  4025



<210> 5220
<211> 395
<212> PRT
<213> Homo sapiens
<308> Q9Y259
<400> 5220

Met Ala Ala Glu Ala Thr Ala Val Ala Gly Ser Gly Ala Val Gly Gly 
  1               5                  10                  15
Cys Leu Ala Lys Asp Gly Leu Gln Gln Ser Lys Cys Pro Asp Thr Thr 
             20                  25                  30
Pro Lys Arg Arg Arg Ala Ser Ser Leu Ser Arg Asp Ala Glu Arg Arg 
         35                  40                  45
Ala Tyr Gln Trp Cys Arg Glu Tyr Leu Gly Gly Ala Trp Arg Arg Val 
     50                  55                  60
Gln Pro Glu Glu Leu Arg Val Tyr Pro Val Ser Gly Gly Leu Ser Asn 
 65                  70                  75                  80
Leu Leu Phe Arg Cys Ser Leu Pro Asp His Leu Pro Ser Val Gly Glu 
                 85                  90                  95
Glu Pro Arg Glu Val Leu Leu Arg Leu Tyr Gly Ala Ile Leu Gln Gly 
             100                105                110
Val Asp Ser Leu Val Leu Glu Ser Val Met Phe Ala Ile Leu Ala Glu 
         115                120                125
Arg Ser Leu Gly Pro Gln Leu Tyr Gly Val Phe Pro Glu Gly Arg Leu 
     130                135                140
Glu Gln Tyr Ile Pro Ser Arg Pro Leu Lys Thr Gln Glu Leu Arg Glu 
 145                150                155                160
Pro Val Leu Ser Ala Ala Ile Ala Thr Lys Met Ala Gln Phe His Gly 
                 165                170                175
Met Glu Met Pro Phe Thr Lys Glu Pro His Trp Leu Phe Gly Thr Met 
             180                185                190
Glu Arg Tyr Leu Lys Gln Ile Gln Asp Leu Pro Pro Thr Gly Leu Pro 
         195                200                205
Glu Met Asn Leu Leu Glu Met Tyr Ser Leu Lys Asp Glu Met Gly Asn 
     210                215                220
Leu Arg Lys Leu Leu Glu Ser Thr Pro Ser Pro Val Val Phe Cys His 
 225                230                235                240
Asn Asp Ile Gln Glu Gly Asn Ile Leu Leu Leu Ser Glu Pro Glu Asn 
                 245                250                255
Ala Asp Ser Leu Met Leu Val Asp Phe Glu Tyr Ser Ser Tyr Asn Tyr 
             260                265                270
Arg Gly Phe Asp Ile Gly Asn His Phe Cys Glu Trp Val Tyr Asp Tyr 
         275                280                285
Thr His Glu Glu Trp Pro Phe Tyr Lys Ala Arg Pro Thr Asp Tyr Pro 
     290                295                300
Thr Gln Glu Gln Gln Leu His Phe Ile Arg His Tyr Leu Ala Glu Ala 
 305                310                315                320
Lys Lys Gly Glu Thr Leu Ser Gln Glu Glu Gln Arg Lys Leu Glu Glu 
                 325                330                335
Asp Leu Leu Val Glu Val Ser Arg Tyr Ala Leu Ala Ser His Phe Phe 
             340                345                350
Trp Gly Leu Trp Ser Ile Leu Gln Ala Ser Met Ser Thr Ile Glu Phe 
         355                360                365
Gly Tyr Leu Asp Tyr Ala Gln Ser Arg Phe Gln Phe Tyr Phe Gln Gln 
     370                375                380
Lys Gly Gln Leu Thr Ser Val His Ser Ser Ser 
 385                390                395



<210> 5221
<211> 502
<212> DNA
<213> Rattus norvegicus
<308> AA875054
<400> 5221

ttttttttt  tttttttgt  acacaggca  tgtttattc  taagcttta  agtgaaagt  60
aagtttgaa  ggatagttt  ctaccataa  aacactggg  ggtagggtg  ggtgagata  120
aacaggtat  agcttgtgt  cagaggact  acttaagac  taaagctct  catctctac  180
ggtgaacat  gatggagga  ccattgcct  gggacatcc  ctgggagca  ctggctgta  240
gattctagt  accttgtta  acaccctgg  gagagtggg  gggactcgt  gtgttgcag  300
cctgtgcat  gggggtggg  tggggatcg  aatgtgtgt  cagagaggg  gagccacca  360
ccttacagt  ctcattcaa  cactaaaca  aaagaacgt  agaccagag  accaaagtg  420
ggacaggaa  ccaggtcga  agctcgttg  actttaatg  gagacaccc  aggctaaga  480
attacaccc  acactgtca  aa  502



<210> 5222
<211> 556
<212> PRT
<213> Rattus norvegicus
<308> P28480
<400> 5222

Met Glu Gly Pro Leu Ser Val Phe Gly Asp Arg Ser Thr Gly Glu Ala 
  1               5                  10                  15
Ile Arg Ser Gln Asn Val Met Ala Ala Ala Ser Ile Ala Asn Ile Val 
             20                  25                  30
Lys Ser Ser Leu Gly Pro Val Gly Leu Asp Lys Met Leu Val Asp Asp 
         35                  40                  45
Ile Gly Asp Val Thr Ile Thr Asn Asp Gly Ala Thr Ile Leu Lys Leu 
     50                  55                  60
Leu Glu Val Glu His Pro Ala Ala Lys Val Leu Cys Glu Leu Ala Asp 
 65                  70                  75                  80
Leu Gln Asp Lys Glu Val Gly Asp Gly Thr Thr Ser Val Val Ile Ile 
                 85                  90                  95
Ala Ala Glu Leu Leu Lys Asn Ala Asp Glu Leu Val Lys Gln Lys Ile 
             100                105                110
His Pro Thr Ser Val Ile Ser Gly Tyr Arg Leu Ala Cys Lys Glu Ala 
         115                120                125
Val Arg Tyr Ile Asn Glu Asn Leu Ile Ile Asn Thr Asp Glu Leu Gly 
     130                135                140
Arg Asp Cys Leu Ile Asn Ala Ala Lys Thr Ser Met Ser Ser Lys Ile 
 145                150                155                160
Ile Gly Ile Asn Gly Asp Phe Phe Ala Asn Met Val Val Asp Ala Val 
                 165                170                175
Leu Ala Val Lys Tyr Thr Asp Ile Arg Gly Gln Pro Arg Tyr Pro Val 
             180                185                190
Asn Ser Val Asn Ile Leu Lys Ala His Gly Arg Ser Gln Ile Glu Ser 
         195                200                205
Met Leu Ile Asn Gly Tyr Ala Leu Asn Cys Val Val Gly Ser Gln Gly 
     210                215                220
Met Leu Lys Arg Ile Val Asn Ala Lys Ile Ala Cys Leu Asp Phe Ser 
 225                230                235                240
Leu Gln Lys Thr Lys Met Lys Leu Gly Val Gln Val Val Ile Thr Asp 
                 245                250                255
Pro Glu Lys Leu Asp Gln Ile Arg Gln Arg Glu Ser Asp Ile Thr Lys 
             260                265                270
Glu Arg Ile Gln Lys Ile Leu Ala Thr Gly Ala Asn Val Ile Leu Thr 
         275                280                285
Thr Gly Gly Ile Asp Asp Met Cys Leu Lys Tyr Phe Val Glu Ala Gly 
     290                295                300
Ala Met Ala Val Arg Arg Val Leu Lys Arg Asp Leu Lys Arg Ile Ala 
 305                310                315                320
Lys Ala Ser Gly Ala Ser Ile Leu Ser Thr Leu Ala Asn Leu Glu Gly 
                 325                330                335
Glu Glu Thr Phe Glu Ala Thr Met Leu Gly Gln Ala Glu Glu Val Val 
             340                345                350
Gln Glu Arg Ile Cys Asp Asp Glu Leu Ile Leu Ile Lys Asn Thr Lys 
         355                360                365
Ala Arg Thr Ser Ala Ser Ile Ile Leu Arg Gly Ala Asn Asp Phe Met 
     370                375                380
Cys Asp Glu Met Glu Arg Ser Leu His Asp Ala Leu Cys Val Val Lys 
 385                390                395                400
Arg Val Leu Glu Ser Lys Ser Val Val Pro Gly Gly Gly Ala Val Glu 
                 405                410                415
Ala Ala Leu Ser Ile Tyr Leu Glu Asn Tyr Ala Thr Ser Met Gly Ser 
             420                425                430
Arg Glu Gln Leu Ala Ile Ala Glu Phe Ala Arg Ser Leu Leu Val Ile 
         435                440                445
Pro Asn Thr Leu Ala Val Asn Ala Ala Gln Asp Ser Thr Asp Leu Val 
     450                455                460
Ala Lys Leu Arg Ala Phe His Asn Glu Ala Gln Val Asn Pro Glu Arg 
 465                470                475                480
Lys Asn Leu Lys Trp Ile Gly Leu Asp Leu Val His Gly Lys Pro Arg 
                 485                490                495
Asp Asn Lys Gln Ala Gly Val Phe Glu Pro Thr Ile Val Lys Val Lys 
             500                505                510
Ser Leu Lys Phe Ala Thr Glu Ala Ala Ile Thr Ile Leu Arg Ile Asp 
         515                520                525
Asp Leu Ile Lys Leu His Pro Glu Ser Lys Asp Asp Lys His Gly Gly 
     530                535                540
Tyr Glu Asn Ala Val His Ser Gly Ala Leu Asp Asp 
 545                550                555



<210> 5223
<211> 634
<212> DNA
<213> Homo sapiens
<308> BG198443
<400> 5223

cacctacaa  ccagctcac  agataaaat  ggctgcagg  atgttctac  tccagtaac  60
tcaggatgg  tgcaccatc  ttagtaatg  ttacatcac  agtatcatc  accaacatt  120
tatccaaga  aacggacca  gagcacttt  tacaatatt  gcaatcgaa  ctgcagcca  180
aatgttctg  gagcggatc  cctccccac  gctgcggtc  ccgaacacg  acaaaggcc  240
ctccatctt  ctggcggcg  tacataccg  attctgctc  tactgcggg  aaccagtta  300
cgtggcctc  cggccaacc  gctaccaca  cagtggcga  ggtgtggag  ggacccgag  360
gatgcaccg  cccatccgc  tcccggctg  cccggctgg  cgcggggca  ggcgggaag  420
agatctctg  acttttatt  tgccattag  aatattagc  cttcttccc  actttcagg  480
aactatcaa  gtactaaac  ggatagaca  caaaatctt  tgacaacat  taaatgtat  540
aaatgtatt  tattactaa  atatataaa  tttaaaaat  acatttgaa  tatgtactt  600
aaaaataaa  attctaaat  taaaaaaaa  aaaa  634



<210> 5224
<211> 365
<212> PRT
<213> Homo sapiens
<308> AAH12496
<400> 5224

Met Gly Thr Thr Val Ile Lys Glu Val Leu Gln Arg Ala Lys Val Ala 
  1               5                  10                  15
Pro Glu Glu Val Ser Glu Val Ile Phe Gly His Val Leu Thr Ala Gly 
             20                  25                  30
Cys Gly Gln Asn Pro Thr Arg Gln Ala Ser Val Gly Ala Gly Ile Pro 
         35                  40                  45
Tyr Ser Val Pro Ala Trp Ser Cys Gln Met Ile Cys Gly Ser Gly Leu 
     50                  55                  60
Lys Ala Val Cys Leu Ala Ala Gln Ser Leu Ala Met Gly Asp Ser Thr 
 65                  70                  75                  80
Ile Val Val Ala Gly Gly Met Glu Asn Met Ser Lys Ala Pro His Leu 
                 85                  90                  95
Thr His Leu Arg Thr Gly Val Arg Met Gly Glu Val Pro Leu Ala Asp 
             100                105                110
Ser Ile Leu Cys Asp Gly Leu Thr Asp Ala Phe His Asn Tyr His Met 
         115                120                125
Gly Ile Thr Ala Glu Asn Val Ala Lys Lys Trp Gln Val Ser Arg Glu 
     130                135                140
Ala Gln Asp Lys Val Ala Val Leu Ser Gln Asn Arg Ala Glu His Ala 
 145                150                155                160
Gln Lys Ala Gly His Phe Asp Lys Glu Ile Val Pro Val Leu Val Ser 
                 165                170                175
Ser Arg Lys Gly Leu Thr Glu Val Lys Ile Asp Glu Phe Pro Arg His 
             180                185                190
Gly Ser Asn Leu Glu Ala Met Gly Lys Leu Lys Pro Tyr Phe Leu Thr 
         195                200                205
Asp Gly Thr Gly Thr Val Thr Pro Ala Asn Ala Ser Gly Met Asn Asp 
     210                215                220
Gly Ala Ala Ala Val Val Leu Met Lys Lys Thr Glu Ala Glu Arg Arg 
 225                230                235                240
Met Leu Lys Pro Leu Ala Arg Ile Val Ser Trp Ser Gln Ala Gly Val 
                 245                250                255
Glu Pro Ser Val Met Gly Val Gly Pro Ile Pro Ala Ile Lys Gln Ala 
             260                265                270
Val Ala Lys Ala Gly Trp Ser Leu Glu Asp Val Asp Leu Phe Glu Ile 
         275                280                285
Asn Glu Ala Phe Ala Ala Val Ser Ala Ala Ile Ala Lys Glu Leu Gly 
     290                295                300
Leu Asn Pro Glu Lys Val Asn Ile Asp Gly Gly Ala Ile Ala Leu Gly 
 305                310                315                320
His Pro Leu Gly Ala Ser Gly Cys Arg Ile Leu Val Thr Leu Leu His 
                 325                330                335
Thr Leu Glu Arg Val Gly Gly Thr Arg Gly Val Ala Ala Leu Cys Ile 
             340                345                350
Gly Gly Gly Met Gly Val Ala Met Cys Val Gln Arg Gly 
         355                360                365



<210> 5225
<211> 507
<212> DNA
<213> Rattus norvegicus
<308> AA875059
<400> 5225

ttttttttt  tttttttag  aaatatggt  tttaatatt  tctcctttt  gcatttata  60
cataattca  ttagacaat  acagaatcc  tttcttcca  taccacaaa  tgtattaca  120
atgaaatct  gtactgctg  ttatcaaaa  atacaagac  atcgctgtt  tatataaaa  180
cactttata  gttaacttg  tcccgaaaa  ctttttttt  cttttttgg  ctggtttta  240
aaaaagttg  tacaaatat  tacagcatt  tcttctgtt  gatgaacat  cttacaaac  300
gaaaaaggg  attttatga  cagaccatg  aaaacacta  acaatgtta  aggcttcta  360
ctgtgctat  tgcccccct  aaatacagt  ctgaaaata  ctatccatc  ttgctgtcc  420
actctgttc  tagtaaact  ccattttct  taagcagtc  attcaccaa  agaaaatga  480
aagtcaagg  cgctctgca  gttatct  507



<210> 5226
<211> 354
<212> DNA
<213> Homo sapiens
<308> R67025
<400> 5226

aaatgttgt  acaaatatt  acagcattt  cttctgtta  acgaacatt  ttaaaaact  60
aaaagggga  ttttgatga  cagaccacg  aaaacacca  acaatgtca  aggctccta  120
ctgtgctat  ttttttttc  tagatacag  actgaaaat  cccatcaaa  tcgtcatcc  180
aatccattc  gttcacact  aaactcaca  tttctctaa  tagtctatt  agcagtaga  240
attgaaagt  aaggccgct  tgcactggg  tcttctttc  gaaagggag  ttgggggaa  300
atggcaaaa  gctttacag  gagggagtt  aaaccacaa  agtcagtct  tggg  354



<210> 5227
<211> 558
<212> DNA
<213> Rattus norvegicus
<308> AA875069
<400> 5227

ttttttttt  tttttgtaa  aaattgttt  taatatgtt  catttgtac  taagtcatt  60
catctttca  tcaggatga  tggaaagag  gactgttca  agacctcag  gatgtgagc  120
ctgtggctc  ggagtgaca  gttgctaat  tgcagaagg  atgggtgat  cttcttgct  180
ctcatgatg  atgtttctg  atgttaatg  cttgttggg  agctattaa  gtactagaa  240
tgataaatg  gtacagggt  cttttgcaa  aaaactggt  atgacttga  ccaagtgtt  300
aaccataca  cactgtgat  gaatgtggg  tttttcaaa  gttgaagat  caagtttta  360
ccacagtgt  acagtttcc  ttaaaaaaa  aagtaaacc  ggcagctat  gaatacact  420
tgtgcattt  taatagcta  tttatatat  gtagtgttc  acattttta  attatgttt  480
acattcaca  gtggtgggg  gtcttgtca  taaggtgtg  gtaatttag  ccagttggt  540
tttctgact  gactgcat  558



<210> 5228
<211> 135
<212> PRT
<213> Rattus norvegicus
<308> P06351
<400> 5228

Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro 
  1               5                  10                  15
Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ser Thr 
             20                  25                  30
Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala Leu 
         35                  40                  45
Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg Lys 
     50                  55                  60
Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys Thr 
 65                  70                  75                  80
Asp Leu Arg Phe Gln Ser Ala Ala Ile Gly Ala Leu Gln Glu Ala Ser 
                 85                  90                  95
Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala Ile 
             100                105                110
His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala Arg 
         115                120                125
Arg Ile Arg Gly Glu Arg Ala 
     130                135



<210> 5229
<211> 498
<212> DNA
<213> Rattus norvegicus
<308> AA875090
<400> 5229

ttttttttt  tttttttga  aacagcagt  gtggtttta  tgtgtccaa  aaacacatc  60
ataaatgaa  ttcaagcct  agcctgtag  tgccctgat  ctccttgcc  aggcctagg  120
accagcccc  ttctcacct  ttccgggga  gagtgggta  aggaggtgg  ctggctgta  180
tgtctaact  acgtgaggt  tgcacatca  aagcacaaa  tgggcaccg  atgttgtgg  240
ttataagct  acttgatag  acaagcctc  gatgaaagg  ctgtcagct  ctaggaagc  300
gctactggt  cgcctggtt  tgttcaggc  tctgaggta  gaaggaagg  ctangggcg  360
ggcttagcc  accttcacc  ggcagcagg  atataaata  agagtataa  tatagttgg  420
ctactagcc  aaaaacaac  aagaaacaa  caggagaga  ggacactag  catgtgggc  480
ggtcaagac  gtgccact  498



<210> 5230
<211> 1542
<212> DNA
<213> Homo sapiens
<308> NM_017595
<400> 5230

ggcacgagg  gcgagctcg  agggcccgg  tggtgctgc  ggggccccg  gaggttgaa  60
actaagcat  gggaagagc  gcaaggtgg  cgtgtgtgg  caggcgtct  tgggcaaaa  120
ttcaatcct  gagcagctt  tgtatggga  ccatgtagt  ggttcggag  tgatcgaga  180
gcaggagga  atctacgtg  gctccattg  gacagaccg  ggggtgcga  agcaggtgc  240
tttctatga  acccggggg  tccgagatg  ggccgaact  ccccgacac  gcttctctt  300
cactgatgg  tacgtcctg  tctatagca  agatagcag  gagtctttt  agcgtgtgg  360
gctgctcaa  aaggagatt  acaaatcca  ggacaagaa  gaggtcacc  tcgtggtcc  420
tggcaacaa  tgtgactta  aggagcagc  gcgtgtaga  ccagatgtg  ctcagcact  480
ggccaagtc  gagaaggtg  agctgtggg  ggtgtcagt  gcggaccgg  gctccctcc  540
ggagccctt  gtctacttg  ccagcaaga  gacgcaacc  cagagcaag  ctgccttcc  600
cctcagccg  aagaacaag  gcagcggct  cttggatgg  tgaagagct  ccgttcctc  660
ttcacgatc  cagccccat  tcagtgtct  gggctctgg  agatgtgtt  agggcaaag  720
agaggacaa  ctgtctttc  cagtcagcc  gggagctcc  cgccaggcc  cgccccagc  780
actttgctc  ctctcacct  tgggaagtg  aaatactct  ggttgacat  cccttcctc  840
gccctccca  cctactccc  atcccagct  ttagaggat  tgctccact  tctcctggg  900
cagttgtgg  tcactgtcc  ttccagctg  cccagacag  aagcagagt  accacgcag  960
agtgtccct  cttgggtct  agttcctat  ataggtagg  gccccaccc  ctgggcttc  1020
catcagcga  acacacaca  ttatggcac  agcctggac  ccagaaaaa  ggtgtccag  1080
tattgtgtg  atgcattta  ttgtgcaca  acaaatatg  tcctatact  gcattaggc  1140
tctcctcat  cctcaccct  acctttctc  tgtcctttt  ttggctgga  gaagttggc  1200
tcctgggag  gtagttttc  gttttaaat  ccccacccc  ggctgggct  agtggctca  1260
ccctgtaat  ccagcactt  gggaggcca  ggcgggtcg  ttacttgag  tcaggagtt  1320
acgaccagc  tggccaaca  tgtgaaacc  catctctgc  aaaaataca  aagttagcc  1380
ggcgtagtg  cacatgcct  taatcccag  tacccgggg  ggctgaggc  ggagaattg  1440
ttgaactca  aaggcggag  ctgcagtga  ccgagatcg  gccactgca  tccagcctg  1500
tcaacagag  aagactcca  ctcgaaaaa  aaaaaaaaa  aa  1542



<210> 5231
<211> 191
<212> PRT
<213> Homo sapiens
<308> NP_060065
<400> 5231

Met Gly Lys Ser Cys Lys Val Val Val Cys Gly Gln Ala Ser Val Gly 
  1               5                  10                  15
Lys Thr Ser Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Val Val Gly 
             20                  25                  30
Ser Glu Met Ile Glu Thr Gln Glu Asp Ile Tyr Val Gly Ser Ile Glu 
         35                  40                  45
Thr Asp Arg Gly Val Arg Glu Gln Val Arg Phe Tyr Asp Thr Arg Gly 
     50                  55                  60
Leu Arg Asp Gly Ala Glu Leu Pro Arg His Cys Phe Ser Cys Thr Asp 
 65                  70                  75                  80
Gly Tyr Val Leu Val Tyr Ser Thr Asp Ser Arg Glu Ser Phe Gln Arg 
                 85                  90                  95
Val Glu Leu Leu Lys Lys Glu Ile Asp Lys Ser Lys Asp Lys Lys Glu 
             100                105                110
Val Thr Ile Val Val Leu Gly Asn Lys Cys Asp Leu Gln Glu Gln Arg 
         115                120                125
Arg Val Asp Pro Asp Val Ala Gln His Trp Ala Lys Ser Glu Lys Val 
     130                135                140
Lys Leu Trp Glu Val Ser Val Ala Asp Arg Arg Ser Leu Leu Glu Pro 
 145                150                155                160
Phe Val Tyr Leu Ala Ser Lys Met Thr Gln Pro Gln Ser Lys Ser Ala 
                 165                170                175
Phe Pro Leu Ser Arg Lys Asn Lys Gly Ser Gly Ser Leu Asp Gly 
             180                185                190



<210> 5232
<211> 465
<212> DNA
<213> Rattus norvegicus
<308> AA875099
<400> 5232

ttttttttt  tttttttcg  cacactgaa  ggatttatt  gccttaatc  tcctcacaa  60
agtttcaag  tacctagaa  ttctcagaa  gtcacagta  aaagaggaa  gaatgtgac  120
aagtttagg  gcaaaggga  gcagcaaca  ggtgacgtg  cctggtcag  ctcagtgct  180
agacgtcct  tttctgcag  aaaatcttg  gcaactcat  agcatcctc  ctcgtcttc  240
cccgaatca  catggtgac  gggagagtg  gctgcttct  atcaagtgg  gggttgggg  300
cacagacga  aaggacatt  ttcttccct  tccgggtgc  cggcatatt  ggtgggatc  360
gaacattca  cagaatgtt  cctaggttg  tgtctgccc  caccaagag  tgggtcttc  420
gagttgctg  gggttttaa  tgcagggtc  ccacaccct  ctctt  465



<210> 5233
<211> 467
<212> PRT
<213> Rattus norvegicus
<308> O08587
<400> 5233

Met Ala Lys Arg Val Ala Glu Lys Glu Leu Thr Asp Arg Asn Trp Asp 
  1               5                  10                  15
Glu Glu Asp Glu Val Glu Glu Met Gly Thr Phe Ser Val Ala Ser Glu 
             20                  25                  30
Glu Val Met Lys Asn Arg Ala Val Lys Lys Ala Lys Arg Arg Asn Ile 
         35                  40                  45
Gly Phe Glu Ser Asp Ser Gly Gly Ala Phe Lys Gly Phe Lys Gly Leu 
     50                  55                  60
Val Val Pro Ser Gly Gly Gly Gly Phe Ser Gly Phe Gly Gly Gly Ser 
 65                  70                  75                  80
Gly Gly Lys Pro Leu Glu Gly Leu Thr Asn Gly Asn Ser Thr Asp Ser 
                 85                  90                  95
Ala Thr Pro Phe Ser Ser Ala Lys Thr Ala Ala Glu Pro Lys Ala Ala 
             100                105                110
Phe Gly Ser Phe Ala Val Asn Gly Pro Thr Thr Leu Val Asp Lys Lys 
         115                120                125
Ile Ser Ser Pro Lys Cys Asn Ser Ser Asn Gln Pro Pro Ser Ser Gly 
     130                135                140
Pro Ala Ser Ser Thr Ser Cys Thr Gly Asn Thr Tyr His Lys Gln Leu 
 145                150                155                160
Ala Gly Leu Asn Cys Ser Val Arg Asp Trp Ile Val Lys His Val Asn 
                 165                170                175
Thr Asn Pro Leu Cys Asp Leu Thr Pro Ile Phe Lys Asp Tyr Glu Arg 
             180                185                190
Tyr Leu Ala Thr Ile Glu Lys Gln Leu Glu Asn Gly Gly Ser Ser Ser 
         195                200                205
Ser Glu Arg Gln Thr Asp Arg Ala Thr Ala Ala Met Glu Pro Pro Ser 
     210                215                220
Leu Phe Gly Ser Thr Lys Leu Gln Gln Asp Ser Pro Phe Ser Phe His 
 225                230                235                240
Gly Asn Lys Ala Glu Asp Thr Ser Glu Lys Leu Glu Phe Thr Ala Glu 
                 245                250                255
Lys Lys Ser Asp Ala Ala Gln Gly Ala Thr Ser Ala Ser Phe Asn Phe 
             260                265                270
Gly Lys Lys Ile Glu Ser Ser Val Leu Gly Ser Leu Ser Ser Gly Ser 
         275                280                285
Leu Thr Gly Phe Ser Phe Ser Pro Gly Asn Ser Ser Leu Phe Gly Lys 
     290                295                300
Asp Ala Ala Gln Ser Lys Ala Ala Ser Ser Pro Phe Ser Ala Lys Ala 
 305                310                315                320
Ser Glu Ser Gln Ala Gly Gly Ser Ser Ser Glu Cys Arg Asp Gly Glu 
                 325                330                335
Glu Glu Glu Ser Asp Glu Pro Pro Lys Val Val Val Thr Glu Val Lys 
             340                345                350
Glu Glu Asp Ala Phe Tyr Ser Lys Lys Cys Lys Leu Phe Tyr Lys Lys 
         355                360                365
Asp Asn Glu Phe Lys Glu Lys Gly Val Gly Thr Leu His Leu Lys Pro 
     370                375                380
Thr Ala Thr Gln Lys Thr Gln Leu Leu Val Arg Ala Asp Thr Asn Leu 
 385                390                395                400
Gly Asn Ile Leu Leu Asn Val Leu Ile Pro Pro Asn Met Pro Cys Thr 
                 405                410                415
Arg Thr Gly Lys Asn Asn Val Leu Ile Val Cys Val Pro Asn Pro Pro 
             420                425                430
Leu Asp Glu Lys Gln Pro Thr Leu Pro Val Thr Met Leu Ile Arg Val 
         435                440                445
Lys Thr Ser Glu Asp Ala Asp Glu Leu His Lys Ile Leu Leu Gln Lys 
     450                455                460
Lys Asp Val 
 465



<210> 5234
<211> 1757
<212> DNA
<213> Homo sapiens
<308> NM_007172
<400> 5234

cgagcacta  gtcctctga  ttccgcagc  cagcaccgg  agcggccga  cgcgctcag  60
ccggcgacc  ctgcgggct  cagacccct  cgccgctgc  ccccgggtt  cgccgcaac  120
aagacccag  gagtgcagc  gcggccgct  aggaggttc  aaaacatgg  caaaagaaa  180
gccgagaag  aactgacag  taggaattg  gatcaagaa  atgaagctg  agaggtggg  240
acattctcc  tggccagtg  ggaagtctt  aagaataga  ccataaaga  agcaaagcg  300
agaaatgtt  gatttgaat  tgacactgg  ggagccttt  aaggtttta  aggtttggt  360
gtaccttct  gaggaggac  cttttctgg  tttggtagt  gcgctggag  gaagccttt  420
gaaggactg  cgaatggaa  caacataac  agtgcccct  ccttcgcca  tgcaaaggc  480
gcggcagat  ccaaggtag  ctttggttc  cttgctgca  atggcccta  caccttggt  540
gataaagtt  caaatccca  aactaatgg  gacagtcag  agccctcct  ctctggcct  600
gcttccagt  aagcttgtg  cggaaatgc  tatcacaag  agttggccg  cttgaactg  660
tccgtgcgg  attggatag  gaagcacgt  aatacaaac  ccctctgtg  tctgacacc  720
atctttaaa  actatgaga  atatttagc  aacattgaa  agcaacacg  gaacagtgg  780
aggaattct  aaagtgaat  taacaaagt  gcagctgaa  cacagtctc  ttccctttt  840
ggctcaaca  aattacagc  agagtcaag  tttttgttt  atggcaaca  aactgaaga  900
acacctgac  agaagatgg  ggtggcatc  gaaaagaaa  cggacccat  atcactagg  960
gcgacaagt  cctcattta  tttcggcaa  aaagttgat  gctctgttt  gggctcatt  1020
agctctgtc  ccctgactg  attttcttt  tcccctgga  actccagtt  atttggcaa  1080
gatactacc  agagtaaac  agtctcttc  ccatttccc  ctaaaccat  ggagggcca  1140
gcagaaggt  acagtggtg  atgcaaagg  ggagatgaa  aagagaatg  tgagccacc  1200
aaagtagta  ttaccgaag  aaaagaaga  gatgctttt  actccaaaa  gtgtaaact  1260
ttttacaag  aggacaatg  gtttaaaga  aaaggcata  gtactctgc  tttaaaacc  1320
acagcaaat  agaagacac  gcttttggt  cgggcagac  ccaatttag  caacatatt  1380
ctgaacgtt  tgattccac  caatatgcc  tgtacgcga  cagggaaga  taacgttct  1440
atcgtctgt  ttccaaatc  accaattga  gagaagaat  ccaccatgc  agtcaccat  1500
ttgattcgg  taaaaacca  cgaggatgc  gacgagttg  acaaaattt  actggagaa  1560
aaggatgcc  gaacacgca  agtcggctg  agaattatt  ccaagttgc  gctgcttcc  1620
ccgcccctt  aagttagtc  gtttttctt  tcttctttg  cattctaag  acttataga  1680
aacttaaaa  ttttgtgag  aagattaat  tggccaata  aacctttaa  tgttaagtg  1740
caaaaaaaa  aaaaaaa  1757



<210> 5235
<211> 468
<212> PRT
<213> Homo sapiens
<308> Q9UKX7
<400> 5235

Met Ala Lys Arg Asn Ala Glu Lys Glu Leu Thr Asp Arg Asn Trp Asp 
  1               5                  10                  15
Gln Glu Asp Glu Ala Glu Glu Val Gly Thr Phe Ser Met Ala Ser Glu 
             20                  25                  30
Glu Val Leu Lys Asn Arg Ala Ile Lys Lys Ala Lys Arg Arg Asn Val 
         35                  40                  45
Gly Phe Glu Ser Asp Thr Gly Gly Ala Phe Lys Gly Phe Lys Gly Leu 
     50                  55                  60
Val Val Pro Ser Gly Gly Gly Arg Phe Ser Gly Phe Gly Ser Gly Ala 
 65                  70                  75                  80
Gly Gly Lys Pro Leu Glu Gly Leu Ser Asn Gly Asn Asn Ile Thr Ser 
                 85                  90                  95
Ala Pro Pro Phe Ala Ser Ala Lys Ala Ala Ala Asp Pro Lys Val Ala 
             100                105                110
Phe Gly Ser Leu Ala Ala Asn Gly Pro Thr Thr Leu Val Asp Lys Val 
         115                120                125
Ser Asn Pro Lys Thr Asn Gly Asp Ser Gln Gln Pro Ser Ser Ser Gly 
     130                135                140
Leu Ala Ser Ser Lys Ala Cys Val Gly Asn Ala Tyr His Lys Gln Leu 
 145                150                155                160
Ala Ala Leu Asn Cys Ser Val Arg Asp Trp Ile Val Lys His Val Asn 
                 165                170                175
Thr Asn Pro Leu Cys Asp Leu Thr Pro Ile Phe Lys Asp Tyr Glu Lys 
             180                185                190
Tyr Leu Ala Asn Ile Glu Gln Gln His Gly Asn Ser Gly Arg Asn Ser 
         195                200                205
Glu Ser Glu Ser Asn Lys Val Ala Ala Glu Thr Gln Ser Pro Ser Leu 
     210                215                220
Phe Gly Ser Thr Lys Leu Gln Gln Glu Ser Thr Phe Leu Phe His Gly 
 225                230                235                240
Asn Lys Thr Glu Asp Thr Pro Asp Lys Lys Met Glu Val Ala Ser Glu 
                 245                250                255
Lys Lys Thr Asp Pro Ser Ser Leu Gly Ala Thr Ser Ala Ser Phe Asn 
             260                265                270
Phe Gly Lys Lys Val Asp Ser Ser Val Leu Gly Ser Leu Ser Ser Val 
         275                280                285
Pro Leu Thr Gly Phe Ser Phe Ser Pro Gly Asn Ser Ser Leu Phe Gly 
     290                295                300
Lys Asp Thr Thr Gln Ser Lys Pro Val Ser Ser Pro Phe Pro Thr Lys 
 305                310                315                320
Pro Leu Glu Gly Gln Ala Glu Gly Asp Ser Gly Glu Cys Lys Gly Gly 
                 325                330                335
Asp Glu Glu Glu Asn Asp Glu Pro Pro Lys Val Val Val Thr Glu Val 
             340                345                350
Lys Glu Glu Asp Ala Phe Tyr Ser Lys Lys Cys Lys Leu Phe Tyr Lys 
         355                360                365
Lys Asp Asn Glu Phe Lys Glu Lys Gly Ile Gly Thr Leu His Leu Lys 
     370                375                380
Pro Thr Ala Asn Gln Lys Thr Gln Leu Leu Val Arg Ala Asp Thr Asn 
 385                390                395                400
Leu Gly Asn Ile Leu Leu Asn Val Leu Ile Pro Pro Asn Met Pro Cys 
                 405                410                415
Thr Arg Thr Gly Lys Asn Asn Val Leu Ile Val Cys Val Pro Asn Pro 
             420                425                430
Pro Ile Asp Glu Lys Asn Ala Thr Met Pro Val Thr Met Leu Ile Arg 
         435                440                445
Val Lys Thr Ser Glu Asp Ala Asp Glu Leu His Lys Ile Leu Leu Glu 
     450                455                460
Lys Lys Asp Ala 
 465



<210> 5236
<211> 452
<212> DNA
<213> Rattus norvegicus
<308> AA875105
<400> 5236

ttttttttt  tttttttac  ttgccaaat  tttctttaa  ttttttttt  tgagacact  60
ggaattccc  gagcttacc  acaattaac  ctactgtta  atgttaact  taagtcatt  120
cagtgggtc  aacacagag  cccatgcac  ccaccacca  agaaaacac  cagaaaatc  180
ttaaatatt  ccatgactc  gaaggtagg  gagaaggtg  ggaggcctg  cctagggga  240
agtgcttgt  tggaaaagg  cttagattc  atcccaacc  ccgccaaac  ggacagaca  300
gaagagaac  aacagaagg  taagacaga  acaccaaca  ctggattgg  aatacggct  360
ttgagatgc  ctacacgtt  acgtctttg  tgaaccaat  cattttcta  aaaaaaaaa  420
aaaaaaaaa  aacaattgc  gccctcgtg  cg  452



<210> 5237
<211> 559
<212> DNA
<213> Rattus norvegicus
<308> AA875107
<400> 5237

ttttttttt  tttttttgt  ggattatta  ttttcacat  tctattgga  ggcaacagg  60
aagggacgg  ttccatcaa  agaagcatt  acaggttct  gagccattc  aagcttgga  120
ccagaggtt  ctgtgggtg  ctgggcaca  caggcatgt  cccattatc  ctcacaggc  180
ctgggtagt  gtagggtgt  gccttgttg  tcatgctag  atactgggt  taggggcta  240
tcatgggca  aattatagc  aggccccag  cagtgaagg  caccaccag  accggctcc  300
ttgcccagg  attcttaag  aaggcggag  ttcctagag  tgagaaaaa  gtcgccctt  360
gggactgct  cggtgacct  taacactct  gtatcaccc  gctctgcac  ctattggct  420
ctgcgcccc  cttctggga  ggatcctac  actccccaa  gctctactg  gcctcagcc  480
cgggtcaag  cacggtttc  tggaattac  tggtccccg  gcgcccaga  cgcgtactt  540
ctagccctc  tgccgaatt  559



<210> 5238
<211> 583
<212> DNA
<213> Rattus norvegicus
<308> AA875121
<400> 5238

ttttttttt  aaatacatt  aagattgtg  tcatctcca  gcagcaatg  agatgagca  60
aatctttaa  gtatttaaa  aataaaaca  tgggcagaa  agtgcacaa  gtcctggtt  120
tcctggatc  tggagagaa  ggatgggga  gaaaccagc  ctctgtgga  aatgagttc  180
tggcccaca  gcaagaaat  ttcccacat  ttctggatg  ggaaggctc  aggaaaggg  240
cagagaaga  tgctggtgg  aaagggtct  accctttct  tttttctga  ggcagaact  300
gcagagtgg  aatcctgta  acccttggg  aggaagagc  caggctgcc  tgcccttta  360
cagtggtgg  gagtgccca  gccaggaaa  acacaagag  attatttct  caaccacac  420
tttcaagaa  atgccataa  tatgttatt  aatattctc  tttcatagc  ttggacaca  480
agctcgata  attgaaata  tgattcctt  gagacaaaa  tgaaaaaaa  aaaaaaaaa  540
aacctttgc  gccgctcca  catcagcct  gtgccgaat  ctt  583



<210> 5239
<211> 335
<212> PRT
<213> Rattus norvegicus
<308> Q62725
<400> 5239

Met Ser Thr Glu Gly Gly Phe Gly Ser Thr Ser Ser Ser Asp Ala Gln 
  1               5                  10                  15
Gln Ser Leu Gln Ser Phe Trp Pro Arg Val Met Glu Glu Ile Arg Asn 
             20                  25                  30
Leu Thr Val Lys Asp Phe Arg Val Gln Glu Leu Pro Leu Ala Arg Ile 
         35                  40                  45
Lys Lys Ile Met Lys Leu Asp Glu Asp Val Lys Met Ile Ser Ala Glu 
     50                  55                  60
Ala Pro Val Leu Phe Ala Lys Ala Ala Gln Ile Phe Ile Thr Glu Leu 
 65                  70                  75                  80
Thr Leu Arg Ala Trp Ile His Thr Glu Asp Asn Lys Arg Arg Thr Leu 
                 85                  90                  95
Gln Arg Asn Asp Ile Ala Met Ala Ile Thr Lys Phe Asp Gln Phe Asp 
             100                105                110
Phe Leu Ile Asp Ile Val Pro Arg Asp Glu Leu Lys Pro Pro Lys Arg 
         115                120                125
Gln Glu Glu Val Arg Gln Ser Val Thr Pro Ala Glu Pro Val Gln Tyr 
     130                135                140
Tyr Phe Thr Leu Ala Gln Gln Pro Thr Ala Val Gln Val Gln Gly Gln 
 145                150                155                160
Gln Gln Gly Gln Gln Thr Thr Ser Ser Thr Thr Thr Ile Gln Pro Gly 
                 165                170                175
Gln Ile Ile Ile Ala Gln Pro Gln Gln Gly Gln Thr Thr Pro Val Thr 
             180                185                190
Met Gln Val Gly Glu Gly Gln Gln Val Gln Ile Val Gln Ala Gln Pro 
         195                200                205
Gln Gly Gln Ala Gln Gln Ala Gln Ser Gly Thr Gly Gln Thr Met Gln 
     210                215                220
Val Met Gln Gln Ile Ile Thr Asn Thr Gly Glu Ile Gln Gln Ile Pro 
 225                230                235                240
Val Gln Leu Asn Ala Gly Gln Leu Gln Tyr Ile Arg Leu Ala Gln Pro 
                 245                250                255
Val Ser Gly Thr Gln Val Val Gln Gly Gln Ile Gln Thr Leu Ala Thr 
             260                265                270
Asn Ala Gln Gln Ile Thr Gln Thr Glu Val Gln Gln Gly Gln Gln Gln 
         275                280                285
Phe Ser Gln Phe Thr Asp Gly Gln Gln Leu Tyr Gln Ile Gln Gln Val 
     290                295                300
Thr Met Pro Ala Gly Gln Asp Leu Ala Gln Pro Met Phe Ile Gln Ser 
 305                310                315                320
Ala Asn Gln Pro Ser Asp Gly Gln Thr Pro Gln Val Thr Gly Asp 
                 325                330                335



<210> 5240
<211> 2684
<212> DNA
<213> Homo sapiens
<308> AK055329
<400> 5240

ttttaatgg  tttagattg  gtgtccctc  atcttgcct  aagtgggca  ttctggaat  60
gtctaccat  aacttgaga  gtcgttttt  cttggtagt  caaattctg  gaggctgga  120
gtctcagag  agcattttg  ttgaacact  cgtgcagga  tgcagcttc  tcccattag  180
attttcctc  tggaagagt  ctgcagtga  gttagctct  gaaggccag  gggaaattt  240
ctccagagc  gaggcaata  ttgcctgtt  gccacaaga  gcttcccct  gcaacaaag  300
caggctggg  agccagggc  ggtggtttc  ggaccccgc  gatagagac  tagtctatc  360
atgctccca  aaccccttt  atttcctct  aattgaggg  gtgaatgtc  gcagtcctc  420
tctgctgac  atcatcttt  ctgagctac  gttctctga  gtggtaacc  ccttggtcc  480
cttttcatc  ccagctcaa  acactaata  tttcatggt  cactggagc  ttaagagcc  540
gagttaagg  ttttagcac  caattaaat  cagcatgtg  tattattgt  ttatctgag  600
tttaatcgt  agcatgaga  actctaagg  cgctttcgt  gctttggtt  cccatgatg  660
ggttttcta  gaaaggttt  ttgattctg  ttccccttg  gaggtgttt  gccagaagc  720
agtgctgaa  accaaagat  ctaaaagcc  cacagaccc  ccatccagc  tggctcttg  780
ggacagaga  ggttaagca  tccagcttt  gcctccaaa  tgtgcagca  ggggcaggg  840
agtgtgagg  ctatgatgc  gaatgatgg  tgtttgctt  gggatcctg  cagatgctg  900
atctcttta  agatgggag  gaaagaggc  cacacttaa  gtacaggca  tctgatgat  960
tcagtcaga  aaattccta  gataagctg  gatcatgta  ctaagagct  gcaaataat  1020
agcatgcag  catgctgtt  tcacctttg  gacaggatc  tctgggagt  ttttctgaa  1080
tccattcag  gaatatatt  tcttctgtg  tgtgtgact  gtgggatgt  gatgttctg  1140
ttttgcttg  tttgacctc  gtttaaaag  gactttttt  agggcaggc  tctttggag  1200
gcttgaggg  tagggggca  tcaacatct  cggtcatgg  aagtttgcc  gtttgagat  1260
atactcaat  tcttatggt  tctttgtct  tgcccctgc  ctaggtgca  ctgaatgcc  1320
gccagctgc  gtatatccg  ttagcccag  ctgtatcag  cactcaagt  gtgcaggga  1380
agatccaga  acttgccac  aatgctcaa  aggtatgtg  cccagagac  caaggcctg  1440
gttggagac  aggagcaga  ggcttctga  aggaaagga  cgctcagca  acagctgtc  1500
tgccacctc  tccttcaac  agaagcacc  cccccacac  ctccatatc  ttctgcacc  1560
aagaggcat  ggtggtaat  ggaacatta  attcaaagt  ttttctctt  ccatcttgt  1620
ctcaagggg  aaagaaatg  aagtcaggg  aagcctcga  ggtgcctga  agaaacctt  1680
caggtgtgc  cacccatca  acctgggaa  tgttcgaca  atcgcctga  cgtcaggct  1740
tttccatct  taaacccaa  tggctgttg  gttctggca  ctcctgtgc  ctttggaaa  1800
cttacttag  ttttacccc  acctcctct  gcatcccta  ccagaaaaa  tgcccttct  1860
ctctcctct  gtgccctac  atattgatg  ctatgagtc  cagatggtg  gggggctgc  1920
tccctgggc  tgggggtgt  gagggacat  ggtattact  gcagaagat  gggggtgct  1980
gtcaagggg  ggcattgtt  atggattct  ttgcctcag  cccaaaaaa  gcagcgatc  2040
tttaagagc  ggacccgtc  ggcccagct  catttctgg  gatgtatct  ttgacagtg  2100
tgacagagc  gagtttgta  agcaggtct  caaagatct  atttgggaa  atacgagga  2160
tgagccaaa  gcaaggctt  tgagttcca  atagtctct  ggatcatta  gggctgttt  2220
tgtgcccac  ccccggctt  cctaaggac  cggcttttc  gtaactgat  ctgactcac  2280
cccttcccc  agcccctct  tttaacctc  taagattct  ccctgggat  caaaaaaca  2340
aacggcatg  gagtgggag  aaatgagaa  gaagcttct  ggttcctca  aagtcagtt  2400
ggggctggg  acagtgggt  acgcctgta  tcccagcac  ttgggaggg  ggctgaggc  2460
ggtgatcac  tgaggtcgg  agtttgaga  cagcctggc  aacatggca  aaccgtttc  2520
actaaaaat  caaaattag  tgggcgtgg  ggtgcatgc  tgtcatccc  gctacttgg  2580
aggctgaga  acaagaatc  cttgaaccc  ggaggtgga  gttgcagtg  gctgagatt  2640
tgccactgc  ctccagcct  ggcgacaga  tgagactct  tctc  2684



<210> 5241
<211> 136
<212> DNA
<213> Rattus norvegicus
<308> AA875124
<400> 5241

ttttttttt  tttttttaa  tatttaaaa  gaatattta  tgacaacga  aggaagttc  60
agaatatct  tacatctat  tctataatc  atattatat  tatgcagtg  gaaagcaga  120
attgaaatt  gtatag  136



<210> 5242
<211> 596
<212> DNA
<213> Rattus norvegicus
<308> AA875127
<400> 5242

ttttttttt  tttttttca  tattgtatg  aagaccctt  ccacataaa  ataaagctg  60
tgttgaatt  atattattc  agtctcttg  attgctgcc  gaaattgca  ctagaaaag  120
ctttccaga  aaaaatgat  tgcctgagg  aaaacagat  ctcagtatg  taaccctct  180
cctcgacct  tgccagctg  tgtgctaat  tgtcccctg  atccttgtg  gtatccagg  240
ccttgggca  gagaagtcc  ggtctgtcc  tgcatgagg  tggggccac  tggattttc  300
tgtaagtta  caccatagt  atagttgtg  atctttgct  gcaaggggt  agtactctc  360
ggccctgtg  aagggtcac  gctgtttgt  aggaccgtg  taggaccat  gctgtactc  420
aatctatgg  ccttgtctc  actaaacag  atgggacca  cattgaggt  aatgtctcc  480
tatccagct  ctgaactgg  aaatgactc  gtgaaggca  aagtctgag  tggaccacc  540
gtgtgagat  aagtagtac  gtagttatc  agagactga  tatctgagt  tccgat  596



<210> 5243
<211> 135
<212> PRT
<213> Rattus norvegicus
<308> BAB26250
<400> 5243

Met Glu Thr Phe Thr Ser Met Leu Val Pro Cys Cys Leu Val Glu Thr 
  1               5                  10                  15
Arg Thr Ile Asp Leu Asn Ile Ala Met Val Leu Ser Gln Ser Ser Gln 
             20                  25                  30
Thr Ala Met Thr Leu Pro Gln Gly Gln Arg Val Leu Ile Pro Cys Gln 
         35                  40                  45
Gln Arg Cys Thr Thr Ile Thr Met Val Val Thr Tyr Arg Lys Ile Gln 
     50                  55                  60
Val Ala Leu Ala Ser Cys Met Asp Arg Pro Gly Leu Leu Leu Pro Lys 
 65                  70                  75                  80
Asp Leu Asp Ile His Lys Asp Thr Gly Asp Thr Leu Ala His Gln Leu 
                 85                  90                  95
Ala Glu Val Glu Ala Glu Gly Tyr His Thr Glu Tyr Leu Phe Phe Leu 
             100                105                110
Arg His Ile Ile Phe Ile Trp Lys Asp Phe Ser Ser Cys Asn Phe Arg 
         115                120                125
Gln Gln Ser Lys Arg Leu Glu 
     130                135



<210> 5244
<211> 5246
<212> DNA
<213> Homo sapiens
<308> NM_003718
<400> 5244

ggcgctttt  ccggccggc  ctggtgctc  gtgtccctc  gccgccgct  ccgtttccg  60
cgggggaga  ggccaggat  tgacccggg  ggaggccgc  cccgcgccg  gctctgcgg  120
tggctctag  cgatgccga  cagctcgga  acggcgctg  ggggaggcg  gggcctgag  180
tgggcggag  agaggttgg  ggaacgccg  aagcggagg  gattcctgt  ccctcagca  240
ccgccgctg  tgttgccgc  cctgcagcc  cagctcctg  aaccgccgc  gcccccgcc  300
cctctgctc  tcctggctg  tcccggcac  gccgccgcc  cagccgccg  cgccgcggc  360
tcctcctct  gcttcagcc  gggcccccc  ctggaggtc  agcggctgg  gagaggcaa  420
aggcgcgca  gagggcggc  gaagcggcg  cgcgggccc  gcgccgggc  ggaggcgga  480
aagcgtcgg  tcttctcgc  gccccagcc  cagcaggac  gcggtggcg  tgctagtag  540
ggcgggggt  tgaccccgc  ggtggaata  gaggatgtg  gctcccagt  cgagcaggg  600
ctgctgctg  ggggggcca  cgcggcaac  gcggcgacg  ctgccgggg  aacgggggg  660
agcggcggg  gtccggcct  ctcctccgg  acccagcgg  gcggggagg  gtcggagcg  720
aggccccgc  gggaccgcc  cagcagcag  ggccgcagc  aagagcgcc  ccgcgagca  780
cggcggcgg  atgggcagc  cggtggcag  gaggcctcc  agtcccgca  ccgccacag  840
cacagcggc  aggaacggg  cgaggtcgc  aagagcggc  gcagcagca  cagcggcgg  900
cgccggaaa  gcgcttcgg  cacatccag  agcagtagc  gccgcaagg  ccgggactc  960
aaggcccac  gcagccgga  taagtcgtc  aaggagccg  cttcggcct  caaggaacc  1020
cccaaggcc  accgggagg  caagaccga  cctaaggcc  acaggcggc  gcggtccct  1080
agcccactg  gaggccggg  cgacagccc  gtgtcccac  gggcctctc  gagcctgag  1140
agccgcaag  cccccagcc  ggcaggagg  ggcagcagc  cctattctc  gcggctgcc  1200
cgctccccg  gcccctaca  tcgccgccg  tcccccagc  acagccgcc  cagctccta  1260
gagcggggc  gcgacgtgt  ccctagtcc  tacagcagc  gcagctggc  ccgctctcg  1320
agtccctac  gccctgtgc  cagacggtc  ggaaaatcc  gaagcagaa  cccgtattc  1380
tctaggcat  caagatctc  tagcaggca  agattgtct  gatccagaa  tcgtcattc  1440
agtatttct  ctagcacac  aactctgaa  agtagcctg  cagctgaat  gaacaagaa  1500
aaaaaagca  gagcagcag  ggcagcaag  gccgcagaa  cagcgaaag  tgcagaagc  1560
actaaggct  ctgaggctg  tgccaaggc  gcaaaagct  caaacactt  tacacctac  1620
aaggggaac  cggaaacta  tgccagtgc  tcacaaaca  accatgtga  ggatgtgaa  1680
aaaattaaa  ttgaacatg  accttctcc  tcaagtggt  gaactttaa  aaatgacaa  1740
gcaaaaaca  agccacctc  tcaggtaac  aaggtggaa  ataatttga  tgtagataa  1800
gccaccaag  aagcagtca  agttggaaa  gagagtaaa  ctgctgcta  aaaggagga  1860
tcagtatct  ttaaagaga  aaccaaacc  cttacacca  gcataggag  caaggagaa  1920
gagcaacat  tagctttag  cacctctac  ttaccaccg  tacctttgc  tcccatgct  1980
cctgaagat  aagaagctg  tagcttacg  ggaaatatt  cagtaaaag  agttaaaaa  2040
gaagtagaa  agaaactcc  atgtcttct  gctgattta  cgctgcccc  tgagctacc  2100
ggaggagat  atctttcaa  gagtccaga  gaaaagaaa  caacaacac  gttacatag  2160
aaaaggagg  ctaaaatat  tgggcctcg  tatggtgaa  ccaaagaaa  agatattga  2220
tggggaaaa  tctgcgtgg  taaatttga  atcatcgga  ttattggag  aggtactta  2280
ggacaagtt  acaaagcca  ggataaaga  actggagaa  tggtagcct  aaaaaaagt  2340
cgtctggat  atgaaaagg  aggctttcc  attacagca  ttcgagaaa  taaaattct  2400
cggcagctt  cccatcaga  tattatcaa  atgaaggaa  tagtgactg  taaagaaga  2460
gctttggat  tcaagaagg  caaaggtgc  ttttatctg  tgtttgaat  tatggacca  2520
gatctgatg  gactactgg  atcaggctt  gttcatttt  atgaaaatc  cataaagtc  2580
tttatgaga  agctcatgg  gggtctgga  tattgtcat  agaagaact  tttgcatag  2640
gatattaaa  gttccaata  ccttctaaa  aatagaggg  agataaaac  tgcagactt  2700
ggacttgct  gattgtata  ctcagaaga  agtcggccg  atactaaca  ggtaattac  2760
ttatggtac  gtccacctg  actgctact  ggagaagaa  gatacacac  agccattga  2820
gtatggagc  gtggctgta  ccttggcga  ctcttcact  aaaaaccta  atttcaagc  2880
aatcaggaa  ttgcacaac  agaattaat  agccgaata  gtgggagtc  atgtcctgc  2940
gtgtggcct  atgtaatca  actaccata  ttcaacacc  tgaaaccaa  gaagcaata  3000
cgtcgaaag  taagagaag  atttgtttt  attcctgca  ctgcgctag  cttatttga  3060
tacatgctt  ccttggatc  tagtaagcg  tgcactgct  aacaggctc  tcagtgcga  3120
ttcctccga  atgtggaac  ctcaaaaat  cctccacca  atctccctt  atggcaaga  3180
tgtcatgag  tatggagta  aaagcgaag  agacagaag  agatgggca  gactgatga  3240
gtttccaca  ttaaagccc  caggaagga  ttgtctctg  gcttggatg  cagcagaac  3300
aacacaccc  agggtgtgc  gccatcttc  cagctgaaa  ctcagggca  ctcaaatgt  3360
gcacctgta  aaacaggcc  tggacagca  ttaaaccac  gtgaattgg  aattctact  3420
aacctacta  aatctaaaa  aagtgttaa  atggctgat  ttgtccaag  gttgaacat  3480
aaggtaaac  ctgagactc  acagcagct  aataaaata  accttcctg  tggaatttt  3540
gcaacaggt  aaaaacaga  agatccatc  acaccacaa  aggagtctt  gaaaccgtt  3600
ggaggaatt  agccttctt  tcagaccat  cagcctaaa  tggagactg  tgctgccca  3660
gcggctgtg  agagtgcat  tgcagttct  ttgactcag  taataaagg  tcagcagtc  3720
aagcagaaa  atgtgctac  agaagagag  gaaaatgga  cgggacatg  agcgtcatt  3780
caactcagg  cacctccag  acctagcac  ccggtgtcg  gacaagatg  cctcatcca  3840
catcaagat  tgaggatct  ggagctaac  ccagaacca  accggcctc  aattctgcc  3900
cctgaccaa  gacctcccg  gcctcctga  ccaccacca  tcactgagg  agatctaga  3960
tatcggaca  aaaaccagc  tgtacccac  accagttct  cattaactg  ccctcatgc  4020
ggagtgaag  cagccctgt  acagctgct  gctcagcat  agccccagg  tgaccccaa  4080
agagaaggt  ggattgatt  tcaagcagg  gacacttac  tgtccactt  agactacaa  4140
gacaacttt  gatcctctt  tttctcttc  gctccttat  ttagcaatg  tggtctagg  4200
agcagttct  ctccaccac  agaacgacg  agtttcatt  gaaattcag  tattcagtc  4260
ttggataac  acagtactg  ttcatctca  tctggtggt  cacctcagc  ttctgcctt  4320
tctgagtca  ttcccagtt  agtagctgg  tatggagac  tttacctca  tgctggtcc  4380
atgttgttt  gtggagaca  ggaccatag  tttgaatat  gccatggtc  tattgcagt  4440
ctggcaaac  gcagtgacc  ttccacggg  ccagagagt  ctcatcctt  gccagcaaa  4500
atgcacaac  ataactatg  tggtaactt  caggaaaat  cgagtggcc  cagcctcat  4560
catggacag  cctggactt  tcctgccca  ggacctgga  attcacaag  atacagggg  4620
catattagc  catcaactg  cagaggcag  ggcagaggg  taccatact  agtatctgt  4680
tttcctcag  cacatcatt  ttatctgga  agacttttc  agctgcaat  taaggcagc  4740
atccaagag  cttgaataa  aataattca  caacagctt  atttttatg  ggagaaggg  4800
cttgcatac  atagtttaa  aaagacaaa  aaaaccttt  cttaaattc  tgctgttct  4860
aaaactaga  cgattgtac  tcttcacaa  ttctagtta  caattttat  ttgtattct  4920
gcagtttta  gtggatgct  attttaggg  cataagcct  ttatggccc  cttgcagat  4980
ttctgaact  tgcacattt  tgctttttt  gtaagtttg  accaacttt  atgtaacaa  5040
cagcccctc  ccacctcca  ttttacaac  atcagaaag  gcactgatt  atttggtat  5100
tttcttttt  caaagctac  tttagtcaa  ggtcactgt  agtctttgc  cctgctttc  5160
gtgttattg  gaaaggtgt  ctttgtgct  atttcagaa  ataaaacac  acctttctc  5220
tgatgcaac  gttttataa  aaaaaa  5246



<210> 5245
<211> 418
<212> PRT
<213> Homo sapiens
<308> Q14004
<400> 5245

Met Leu Pro Glu Asp Lys Glu Ala Asp Ser Leu Arg Gly Asn Ile Ser 
  1               5                  10                  15
Val Lys Ala Val Lys Lys Glu Val Glu Lys Lys Leu Arg Cys Leu Leu 
             20                  25                  30
Ala Asp Leu Pro Leu Pro Pro Glu Leu Pro Gly Gly Asp Asp Leu Ser 
         35                  40                  45
Lys Ser Pro Glu Glu Lys Lys Thr Thr Thr Gln Leu His Ser Lys Arg 
     50                  55                  60
Arg Pro Lys Ile Cys Gly Pro Arg Tyr Gly Glu Thr Lys Glu Lys Asp 
 65                  70                  75                  80
Ile Asp Trp Gly Lys Leu Cys Val Asp Lys Phe Asp Ile Ile Gly Ile 
                 85                  90                  95
Ile Gly Glu Gly Thr Tyr Gly Gln Val Tyr Lys Ala Arg Asp Lys Asp 
             100                105                110
Thr Gly Glu Met Val Ala Leu Lys Lys Val Arg Leu Asp Asn Glu Lys 
         115                120                125
Glu Gly Phe Pro Ile Thr Ala Ile Arg Glu Ile Lys Ile Leu Arg Gln 
     130                135                140
Leu Thr His Gln Ser Ile Ile Asn Met Lys Glu Ile Val Thr Asp Lys 
 145                150                155                160
Glu Asp Ala Leu Asp Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val 
                 165                170                175
Phe Glu Tyr Met Asp His Asp Leu Met Gly Leu Leu Glu Ser Gly Leu 
             180                185                190
Val His Phe Tyr Glu Asn His Ile Lys Ser Phe Met Arg Gln Leu Met 
         195                200                205
Glu Gly Leu Asp Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile 
     210                215                220
Lys Cys Ser Asn Ile Leu Leu Asn Asn Arg Gly Gln Ile Lys Leu Ala 
 225                230                235                240
Asp Phe Gly Leu Ala Arg Leu Tyr Ser Ser Glu Glu Ser Arg Pro Tyr 
                 245                250                255
Thr Asn Lys Val Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu 
             260                265                270
Gly Glu Glu Arg Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys 
         275                280                285
Ile Leu Gly Glu Leu Phe Thr Lys Lys Pro Ile Phe Gln Ala Asn Gln 
     290                295                300
Glu Leu Ala Gln Leu Glu Leu Ile Ser Arg Ile Cys Gly Ser Pro Cys 
 305                310                315                320
Pro Ala Val Trp Pro Asp Val Ile Lys Leu Pro Tyr Phe Asn Thr Met 
                 325                330                335
Lys Pro Lys Lys Gln Tyr Arg Arg Lys Leu Arg Glu Glu Phe Val Phe 
             340                345                350
Ile Pro Ala Ala Ala Leu Asp Leu Phe Asp Tyr Met Leu Ala Leu Asp 
         355                360                365
Pro Ser Lys Arg Cys Thr Ala Glu Gln Ala Leu Gln Cys Glu Phe Leu 
     370                375                380
Arg Asp Val Glu Pro Ser Lys Cys Leu His Gln Ile Ser Leu Tyr Gly 
 385                390                395                400
Lys Ile Val Met Ser Tyr Gly Val Lys Ser Glu Glu Asp Arg Ser Arg 
                 405                410                415
Trp Ala 
             420



<210> 5246
<211> 596
<212> DNA
<213> Rattus norvegicus
<308> AA875127
<400> 5246

ttttttttt  tttttttca  tattgtatg  aagaccctt  ccacataaa  ataaagctg  60
tgttgaatt  atattattc  agtctcttg  attgctgcc  gaaattgca  ctagaaaag  120
ctttccaga  aaaaatgat  tgcctgagg  aaaacagat  ctcagtatg  taaccctct  180
cctcgacct  tgccagctg  tgtgctaat  tgtcccctg  atccttgtg  gtatccagg  240
ccttgggca  gagaagtcc  ggtctgtcc  tgcatgagg  tggggccac  tggattttc  300
tgtaagtta  caccatagt  atagttgtg  atctttgct  gcaaggggt  agtactctc  360
ggccctgtg  aagggtcac  gctgtttgt  aggaccgtg  taggaccat  gctgtactc  420
aatctatgg  ccttgtctc  actaaacag  atgggacca  cattgaggt  aatgtctcc  480
tatccagct  ctgaactgg  aaatgactc  gtgaaggca  aagtctgag  tggaccacc  540
gtgtgagat  aagtagtac  gtagttatc  agagactga  tatctgagt  tccgat  596



<210> 5247
<211> 135
<212> PRT
<213> Rattus norvegicus
<308> BAB26250
<400> 5247

Met Glu Thr Phe Thr Ser Met Leu Val Pro Cys Cys Leu Val Glu Thr 
  1               5                  10                  15
Arg Thr Ile Asp Leu Asn Ile Ala Met Val Leu Ser Gln Ser Ser Gln 
             20                  25                  30
Thr Ala Met Thr Leu Pro Gln Gly Gln Arg Val Leu Ile Pro Cys Gln 
         35                  40                  45
Gln Arg Cys Thr Thr Ile Thr Met Val Val Thr Tyr Arg Lys Ile Gln 
     50                  55                  60
Val Ala Leu Ala Ser Cys Met Asp Arg Pro Gly Leu Leu Leu Pro Lys 
 65                  70                  75                  80
Asp Leu Asp Ile His Lys Asp Thr Gly Asp Thr Leu Ala His Gln Leu 
                 85                  90                  95
Ala Glu Val Glu Ala Glu Gly Tyr His Thr Glu Tyr Leu Phe Phe Leu 
             100                105                110
Arg His Ile Ile Phe Ile Trp Lys Asp Phe Ser Ser Cys Asn Phe Arg 
         115                120                125
Gln Gln Ser Lys Arg Leu Glu 
     130                135



<210> 5248
<211> 5246
<212> DNA
<213> Homo sapiens
<308> NM_003718
<400> 5248

ggcgctttt  ccggccggc  ctggtgctc  gtgtccctc  gccgccgct  ccgtttccg  60
cgggggaga  ggccaggat  tgacccggg  ggaggccgc  cccgcgccg  gctctgcgg  120
tggctctag  cgatgccga  cagctcgga  acggcgctg  ggggaggcg  gggcctgag  180
tgggcggag  agaggttgg  ggaacgccg  aagcggagg  gattcctgt  ccctcagca  240
ccgccgctg  tgttgccgc  cctgcagcc  cagctcctg  aaccgccgc  gcccccgcc  300
cctctgctc  tcctggctg  tcccggcac  gccgccgcc  cagccgccg  cgccgcggc  360
tcctcctct  gcttcagcc  gggcccccc  ctggaggtc  agcggctgg  gagaggcaa  420
aggcgcgca  gagggcggc  gaagcggcg  cgcgggccc  gcgccgggc  ggaggcgga  480
aagcgtcgg  tcttctcgc  gccccagcc  cagcaggac  gcggtggcg  tgctagtag  540
ggcgggggt  tgaccccgc  ggtggaata  gaggatgtg  gctcccagt  cgagcaggg  600
ctgctgctg  ggggggcca  cgcggcaac  gcggcgacg  ctgccgggg  aacgggggg  660
agcggcggg  gtccggcct  ctcctccgg  acccagcgg  gcggggagg  gtcggagcg  720
aggccccgc  gggaccgcc  cagcagcag  ggccgcagc  aagagcgcc  ccgcgagca  780
cggcggcgg  atgggcagc  cggtggcag  gaggcctcc  agtcccgca  ccgccacag  840
cacagcggc  aggaacggg  cgaggtcgc  aagagcggc  gcagcagca  cagcggcgg  900
cgccggaaa  gcgcttcgg  cacatccag  agcagtagc  gccgcaagg  ccgggactc  960
aaggcccac  gcagccgga  taagtcgtc  aaggagccg  cttcggcct  caaggaacc  1020
cccaaggcc  accgggagg  caagaccga  cctaaggcc  acaggcggc  gcggtccct  1080
agcccactg  gaggccggg  cgacagccc  gtgtcccac  gggcctctc  gagcctgag  1140
agccgcaag  cccccagcc  ggcaggagg  ggcagcagc  cctattctc  gcggctgcc  1200
cgctccccg  gcccctaca  tcgccgccg  tcccccagc  acagccgcc  cagctccta  1260
gagcggggc  gcgacgtgt  ccctagtcc  tacagcagc  gcagctggc  ccgctctcg  1320
agtccctac  gccctgtgc  cagacggtc  ggaaaatcc  gaagcagaa  cccgtattc  1380
tctaggcat  caagatctc  tagcaggca  agattgtct  gatccagaa  tcgtcattc  1440
agtatttct  ctagcacac  aactctgaa  agtagcctg  cagctgaat  gaacaagaa  1500
aaaaaagca  gagcagcag  ggcagcaag  gccgcagaa  cagcgaaag  tgcagaagc  1560
actaaggct  ctgaggctg  tgccaaggc  gcaaaagct  caaacactt  tacacctac  1620
aaggggaac  cggaaacta  tgccagtgc  tcacaaaca  accatgtga  ggatgtgaa  1680
aaaattaaa  ttgaacatg  accttctcc  tcaagtggt  gaactttaa  aaatgacaa  1740
gcaaaaaca  agccacctc  tcaggtaac  aaggtggaa  ataatttga  tgtagataa  1800
gccaccaag  aagcagtca  agttggaaa  gagagtaaa  ctgctgcta  aaaggagga  1860
tcagtatct  ttaaagaga  aaccaaacc  cttacacca  gcataggag  caaggagaa  1920
gagcaacat  tagctttag  cacctctac  ttaccaccg  tacctttgc  tcccatgct  1980
cctgaagat  aagaagctg  tagcttacg  ggaaatatt  cagtaaaag  agttaaaaa  2040
gaagtagaa  agaaactcc  atgtcttct  gctgattta  cgctgcccc  tgagctacc  2100
ggaggagat  atctttcaa  gagtccaga  gaaaagaaa  caacaacac  gttacatag  2160
aaaaggagg  ctaaaatat  tgggcctcg  tatggtgaa  ccaaagaaa  agatattga  2220
tggggaaaa  tctgcgtgg  taaatttga  atcatcgga  ttattggag  aggtactta  2280
ggacaagtt  acaaagcca  ggataaaga  actggagaa  tggtagcct  aaaaaaagt  2340
cgtctggat  atgaaaagg  aggctttcc  attacagca  ttcgagaaa  taaaattct  2400
cggcagctt  cccatcaga  tattatcaa  atgaaggaa  tagtgactg  taaagaaga  2460
gctttggat  tcaagaagg  caaaggtgc  ttttatctg  tgtttgaat  tatggacca  2520
gatctgatg  gactactgg  atcaggctt  gttcatttt  atgaaaatc  cataaagtc  2580
tttatgaga  agctcatgg  gggtctgga  tattgtcat  agaagaact  tttgcatag  2640
gatattaaa  gttccaata  ccttctaaa  aatagaggg  agataaaac  tgcagactt  2700
ggacttgct  gattgtata  ctcagaaga  agtcggccg  atactaaca  ggtaattac  2760
ttatggtac  gtccacctg  actgctact  ggagaagaa  gatacacac  agccattga  2820
gtatggagc  gtggctgta  ccttggcga  ctcttcact  aaaaaccta  atttcaagc  2880
aatcaggaa  ttgcacaac  agaattaat  agccgaata  gtgggagtc  atgtcctgc  2940
gtgtggcct  atgtaatca  actaccata  ttcaacacc  tgaaaccaa  gaagcaata  3000
cgtcgaaag  taagagaag  atttgtttt  attcctgca  ctgcgctag  cttatttga  3060
tacatgctt  ccttggatc  tagtaagcg  tgcactgct  aacaggctc  tcagtgcga  3120
ttcctccga  atgtggaac  ctcaaaaat  cctccacca  atctccctt  atggcaaga  3180
tgtcatgag  tatggagta  aaagcgaag  agacagaag  agatgggca  gactgatga  3240
gtttccaca  ttaaagccc  caggaagga  ttgtctctg  gcttggatg  cagcagaac  3300
aacacaccc  agggtgtgc  gccatcttc  cagctgaaa  ctcagggca  ctcaaatgt  3360
gcacctgta  aaacaggcc  tggacagca  ttaaaccac  gtgaattgg  aattctact  3420
aacctacta  aatctaaaa  aagtgttaa  atggctgat  ttgtccaag  gttgaacat  3480
aaggtaaac  ctgagactc  acagcagct  aataaaata  accttcctg  tggaatttt  3540
gcaacaggt  aaaaacaga  agatccatc  acaccacaa  aggagtctt  gaaaccgtt  3600
ggaggaatt  agccttctt  tcagaccat  cagcctaaa  tggagactg  tgctgccca  3660
gcggctgtg  agagtgcat  tgcagttct  ttgactcag  taataaagg  tcagcagtc  3720
aagcagaaa  atgtgctac  agaagagag  gaaaatgga  cgggacatg  agcgtcatt  3780
caactcagg  cacctccag  acctagcac  ccggtgtcg  gacaagatg  cctcatcca  3840
catcaagat  tgaggatct  ggagctaac  ccagaacca  accggcctc  aattctgcc  3900
cctgaccaa  gacctcccg  gcctcctga  ccaccacca  tcactgagg  agatctaga  3960
tatcggaca  aaaaccagc  tgtacccac  accagttct  cattaactg  ccctcatgc  4020
ggagtgaag  cagccctgt  acagctgct  gctcagcat  agccccagg  tgaccccaa  4080
agagaaggt  ggattgatt  tcaagcagg  gacacttac  tgtccactt  agactacaa  4140
gacaacttt  gatcctctt  tttctcttc  gctccttat  ttagcaatg  tggtctagg  4200
agcagttct  ctccaccac  agaacgacg  agtttcatt  gaaattcag  tattcagtc  4260
ttggataac  acagtactg  ttcatctca  tctggtggt  cacctcagc  ttctgcctt  4320
tctgagtca  ttcccagtt  agtagctgg  tatggagac  tttacctca  tgctggtcc  4380
atgttgttt  gtggagaca  ggaccatag  tttgaatat  gccatggtc  tattgcagt  4440
ctggcaaac  gcagtgacc  ttccacggg  ccagagagt  ctcatcctt  gccagcaaa  4500
atgcacaac  ataactatg  tggtaactt  caggaaaat  cgagtggcc  cagcctcat  4560
catggacag  cctggactt  tcctgccca  ggacctgga  attcacaag  atacagggg  4620
catattagc  catcaactg  cagaggcag  ggcagaggg  taccatact  agtatctgt  4680
tttcctcag  cacatcatt  ttatctgga  agacttttc  agctgcaat  taaggcagc  4740
atccaagag  cttgaataa  aataattca  caacagctt  atttttatg  ggagaaggg  4800
cttgcatac  atagtttaa  aaagacaaa  aaaaccttt  cttaaattc  tgctgttct  4860
aaaactaga  cgattgtac  tcttcacaa  ttctagtta  caattttat  ttgtattct  4920
gcagtttta  gtggatgct  attttaggg  cataagcct  ttatggccc  cttgcagat  4980
ttctgaact  tgcacattt  tgctttttt  gtaagtttg  accaacttt  atgtaacaa  5040
cagcccctc  ccacctcca  ttttacaac  atcagaaag  gcactgatt  atttggtat  5100
tttcttttt  caaagctac  tttagtcaa  ggtcactgt  agtctttgc  cctgctttc  5160
gtgttattg  gaaaggtgt  ctttgtgct  atttcagaa  ataaaacac  acctttctc  5220
tgatgcaac  gttttataa  aaaaaa  5246



<210> 5249
<211> 418
<212> PRT
<213> Homo sapiens
<308> Q14004
<400> 5249

Met Leu Pro Glu Asp Lys Glu Ala Asp Ser Leu Arg Gly Asn Ile Ser 
  1               5                  10                  15
Val Lys Ala Val Lys Lys Glu Val Glu Lys Lys Leu Arg Cys Leu Leu 
             20                  25                  30
Ala Asp Leu Pro Leu Pro Pro Glu Leu Pro Gly Gly Asp Asp Leu Ser 
         35                  40                  45
Lys Ser Pro Glu Glu Lys Lys Thr Thr Thr Gln Leu His Ser Lys Arg 
     50                  55                  60
Arg Pro Lys Ile Cys Gly Pro Arg Tyr Gly Glu Thr Lys Glu Lys Asp 
 65                  70                  75                  80
Ile Asp Trp Gly Lys Leu Cys Val Asp Lys Phe Asp Ile Ile Gly Ile 
                 85                  90                  95
Ile Gly Glu Gly Thr Tyr Gly Gln Val Tyr Lys Ala Arg Asp Lys Asp 
             100                105                110
Thr Gly Glu Met Val Ala Leu Lys Lys Val Arg Leu Asp Asn Glu Lys 
         115                120                125
Glu Gly Phe Pro Ile Thr Ala Ile Arg Glu Ile Lys Ile Leu Arg Gln 
     130                135                140
Leu Thr His Gln Ser Ile Ile Asn Met Lys Glu Ile Val Thr Asp Lys 
 145                150                155                160
Glu Asp Ala Leu Asp Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val 
                 165                170                175
Phe Glu Tyr Met Asp His Asp Leu Met Gly Leu Leu Glu Ser Gly Leu 
             180                185                190
Val His Phe Tyr Glu Asn His Ile Lys Ser Phe Met Arg Gln Leu Met 
         195                200                205
Glu Gly Leu Asp Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile 
     210                215                220
Lys Cys Ser Asn Ile Leu Leu Asn Asn Arg Gly Gln Ile Lys Leu Ala 
 225                230                235                240
Asp Phe Gly Leu Ala Arg Leu Tyr Ser Ser Glu Glu Ser Arg Pro Tyr 
                 245                250                255
Thr Asn Lys Val Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu 
             260                265                270
Gly Glu Glu Arg Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys 
         275                280                285
Ile Leu Gly Glu Leu Phe Thr Lys Lys Pro Ile Phe Gln Ala Asn Gln 
     290                295                300
Glu Leu Ala Gln Leu Glu Leu Ile Ser Arg Ile Cys Gly Ser Pro Cys 
 305                310                315                320
Pro Ala Val Trp Pro Asp Val Ile Lys Leu Pro Tyr Phe Asn Thr Met 
                 325                330                335
Lys Pro Lys Lys Gln Tyr Arg Arg Lys Leu Arg Glu Glu Phe Val Phe 
             340                345                350
Ile Pro Ala Ala Ala Leu Asp Leu Phe Asp Tyr Met Leu Ala Leu Asp 
         355                360                365
Pro Ser Lys Arg Cys Thr Ala Glu Gln Ala Leu Gln Cys Glu Phe Leu 
     370                375                380
Arg Asp Val Glu Pro Ser Lys Cys Leu His Gln Ile Ser Leu Tyr Gly 
 385                390                395                400
Lys Ile Val Met Ser Tyr Gly Val Lys Ser Glu Glu Asp Arg Ser Arg 
                 405                410                415
Trp Ala 
             420



<210> 5250
<211> 596
<212> DNA
<213> Rattus norvegicus
<308> AA875127
<400> 5250

ttttttttt  tttttttca  tattgtatg  aagaccctt  ccacataaa  ataaagctg  60
tgttgaatt  atattattc  agtctcttg  attgctgcc  gaaattgca  ctagaaaag  120
ctttccaga  aaaaatgat  tgcctgagg  aaaacagat  ctcagtatg  taaccctct  180
cctcgacct  tgccagctg  tgtgctaat  tgtcccctg  atccttgtg  gtatccagg  240
ccttgggca  gagaagtcc  ggtctgtcc  tgcatgagg  tggggccac  tggattttc  300
tgtaagtta  caccatagt  atagttgtg  atctttgct  gcaaggggt  agtactctc  360
ggccctgtg  aagggtcac  gctgtttgt  aggaccgtg  taggaccat  gctgtactc  420
aatctatgg  ccttgtctc  actaaacag  atgggacca  cattgaggt  aatgtctcc  480
tatccagct  ctgaactgg  aaatgactc  gtgaaggca  aagtctgag  tggaccacc  540
gtgtgagat  aagtagtac  gtagttatc  agagactga  tatctgagt  tccgat  596



<210> 5251
<211> 135
<212> PRT
<213> Rattus norvegicus
<308> BAB26250
<400> 5251

Met Glu Thr Phe Thr Ser Met Leu Val Pro Cys Cys Leu Val Glu Thr 
  1               5                  10                  15
Arg Thr Ile Asp Leu Asn Ile Ala Met Val Leu Ser Gln Ser Ser Gln 
             20                  25                  30
Thr Ala Met Thr Leu Pro Gln Gly Gln Arg Val Leu Ile Pro Cys Gln 
         35                  40                  45
Gln Arg Cys Thr Thr Ile Thr Met Val Val Thr Tyr Arg Lys Ile Gln 
     50                  55                  60
Val Ala Leu Ala Ser Cys Met Asp Arg Pro Gly Leu Leu Leu Pro Lys 
 65                  70                  75                  80
Asp Leu Asp Ile His Lys Asp Thr Gly Asp Thr Leu Ala His Gln Leu 
                 85                  90                  95
Ala Glu Val Glu Ala Glu Gly Tyr His Thr Glu Tyr Leu Phe Phe Leu 
             100                105                110
Arg His Ile Ile Phe Ile Trp Lys Asp Phe Ser Ser Cys Asn Phe Arg 
         115                120                125
Gln Gln Ser Lys Arg Leu Glu 
     130                135



<210> 5252
<211> 5246
<212> DNA
<213> Homo sapiens
<308> NM_003718
<400> 5252

ggcgctttt  ccggccggc  ctggtgctc  gtgtccctc  gccgccgct  ccgtttccg  60
cgggggaga  ggccaggat  tgacccggg  ggaggccgc  cccgcgccg  gctctgcgg  120
tggctctag  cgatgccga  cagctcgga  acggcgctg  ggggaggcg  gggcctgag  180
tgggcggag  agaggttgg  ggaacgccg  aagcggagg  gattcctgt  ccctcagca  240
ccgccgctg  tgttgccgc  cctgcagcc  cagctcctg  aaccgccgc  gcccccgcc  300
cctctgctc  tcctggctg  tcccggcac  gccgccgcc  cagccgccg  cgccgcggc  360
tcctcctct  gcttcagcc  gggcccccc  ctggaggtc  agcggctgg  gagaggcaa  420
aggcgcgca  gagggcggc  gaagcggcg  cgcgggccc  gcgccgggc  ggaggcgga  480
aagcgtcgg  tcttctcgc  gccccagcc  cagcaggac  gcggtggcg  tgctagtag  540
ggcgggggt  tgaccccgc  ggtggaata  gaggatgtg  gctcccagt  cgagcaggg  600
ctgctgctg  ggggggcca  cgcggcaac  gcggcgacg  ctgccgggg  aacgggggg  660
agcggcggg  gtccggcct  ctcctccgg  acccagcgg  gcggggagg  gtcggagcg  720
aggccccgc  gggaccgcc  cagcagcag  ggccgcagc  aagagcgcc  ccgcgagca  780
cggcggcgg  atgggcagc  cggtggcag  gaggcctcc  agtcccgca  ccgccacag  840
cacagcggc  aggaacggg  cgaggtcgc  aagagcggc  gcagcagca  cagcggcgg  900
cgccggaaa  gcgcttcgg  cacatccag  agcagtagc  gccgcaagg  ccgggactc  960
aaggcccac  gcagccgga  taagtcgtc  aaggagccg  cttcggcct  caaggaacc  1020
cccaaggcc  accgggagg  caagaccga  cctaaggcc  acaggcggc  gcggtccct  1080
agcccactg  gaggccggg  cgacagccc  gtgtcccac  gggcctctc  gagcctgag  1140
agccgcaag  cccccagcc  ggcaggagg  ggcagcagc  cctattctc  gcggctgcc  1200
cgctccccg  gcccctaca  tcgccgccg  tcccccagc  acagccgcc  cagctccta  1260
gagcggggc  gcgacgtgt  ccctagtcc  tacagcagc  gcagctggc  ccgctctcg  1320
agtccctac  gccctgtgc  cagacggtc  ggaaaatcc  gaagcagaa  cccgtattc  1380
tctaggcat  caagatctc  tagcaggca  agattgtct  gatccagaa  tcgtcattc  1440
agtatttct  ctagcacac  aactctgaa  agtagcctg  cagctgaat  gaacaagaa  1500
aaaaaagca  gagcagcag  ggcagcaag  gccgcagaa  cagcgaaag  tgcagaagc  1560
actaaggct  ctgaggctg  tgccaaggc  gcaaaagct  caaacactt  tacacctac  1620
aaggggaac  cggaaacta  tgccagtgc  tcacaaaca  accatgtga  ggatgtgaa  1680
aaaattaaa  ttgaacatg  accttctcc  tcaagtggt  gaactttaa  aaatgacaa  1740
gcaaaaaca  agccacctc  tcaggtaac  aaggtggaa  ataatttga  tgtagataa  1800
gccaccaag  aagcagtca  agttggaaa  gagagtaaa  ctgctgcta  aaaggagga  1860
tcagtatct  ttaaagaga  aaccaaacc  cttacacca  gcataggag  caaggagaa  1920
gagcaacat  tagctttag  cacctctac  ttaccaccg  tacctttgc  tcccatgct  1980
cctgaagat  aagaagctg  tagcttacg  ggaaatatt  cagtaaaag  agttaaaaa  2040
gaagtagaa  agaaactcc  atgtcttct  gctgattta  cgctgcccc  tgagctacc  2100
ggaggagat  atctttcaa  gagtccaga  gaaaagaaa  caacaacac  gttacatag  2160
aaaaggagg  ctaaaatat  tgggcctcg  tatggtgaa  ccaaagaaa  agatattga  2220
tggggaaaa  tctgcgtgg  taaatttga  atcatcgga  ttattggag  aggtactta  2280
ggacaagtt  acaaagcca  ggataaaga  actggagaa  tggtagcct  aaaaaaagt  2340
cgtctggat  atgaaaagg  aggctttcc  attacagca  ttcgagaaa  taaaattct  2400
cggcagctt  cccatcaga  tattatcaa  atgaaggaa  tagtgactg  taaagaaga  2460
gctttggat  tcaagaagg  caaaggtgc  ttttatctg  tgtttgaat  tatggacca  2520
gatctgatg  gactactgg  atcaggctt  gttcatttt  atgaaaatc  cataaagtc  2580
tttatgaga  agctcatgg  gggtctgga  tattgtcat  agaagaact  tttgcatag  2640
gatattaaa  gttccaata  ccttctaaa  aatagaggg  agataaaac  tgcagactt  2700
ggacttgct  gattgtata  ctcagaaga  agtcggccg  atactaaca  ggtaattac  2760
ttatggtac  gtccacctg  actgctact  ggagaagaa  gatacacac  agccattga  2820
gtatggagc  gtggctgta  ccttggcga  ctcttcact  aaaaaccta  atttcaagc  2880
aatcaggaa  ttgcacaac  agaattaat  agccgaata  gtgggagtc  atgtcctgc  2940
gtgtggcct  atgtaatca  actaccata  ttcaacacc  tgaaaccaa  gaagcaata  3000
cgtcgaaag  taagagaag  atttgtttt  attcctgca  ctgcgctag  cttatttga  3060
tacatgctt  ccttggatc  tagtaagcg  tgcactgct  aacaggctc  tcagtgcga  3120
ttcctccga  atgtggaac  ctcaaaaat  cctccacca  atctccctt  atggcaaga  3180
tgtcatgag  tatggagta  aaagcgaag  agacagaag  agatgggca  gactgatga  3240
gtttccaca  ttaaagccc  caggaagga  ttgtctctg  gcttggatg  cagcagaac  3300
aacacaccc  agggtgtgc  gccatcttc  cagctgaaa  ctcagggca  ctcaaatgt  3360
gcacctgta  aaacaggcc  tggacagca  ttaaaccac  gtgaattgg  aattctact  3420
aacctacta  aatctaaaa  aagtgttaa  atggctgat  ttgtccaag  gttgaacat  3480
aaggtaaac  ctgagactc  acagcagct  aataaaata  accttcctg  tggaatttt  3540
gcaacaggt  aaaaacaga  agatccatc  acaccacaa  aggagtctt  gaaaccgtt  3600
ggaggaatt  agccttctt  tcagaccat  cagcctaaa  tggagactg  tgctgccca  3660
gcggctgtg  agagtgcat  tgcagttct  ttgactcag  taataaagg  tcagcagtc  3720
aagcagaaa  atgtgctac  agaagagag  gaaaatgga  cgggacatg  agcgtcatt  3780
caactcagg  cacctccag  acctagcac  ccggtgtcg  gacaagatg  cctcatcca  3840
catcaagat  tgaggatct  ggagctaac  ccagaacca  accggcctc  aattctgcc  3900
cctgaccaa  gacctcccg  gcctcctga  ccaccacca  tcactgagg  agatctaga  3960
tatcggaca  aaaaccagc  tgtacccac  accagttct  cattaactg  ccctcatgc  4020
ggagtgaag  cagccctgt  acagctgct  gctcagcat  agccccagg  tgaccccaa  4080
agagaaggt  ggattgatt  tcaagcagg  gacacttac  tgtccactt  agactacaa  4140
gacaacttt  gatcctctt  tttctcttc  gctccttat  ttagcaatg  tggtctagg  4200
agcagttct  ctccaccac  agaacgacg  agtttcatt  gaaattcag  tattcagtc  4260
ttggataac  acagtactg  ttcatctca  tctggtggt  cacctcagc  ttctgcctt  4320
tctgagtca  ttcccagtt  agtagctgg  tatggagac  tttacctca  tgctggtcc  4380
atgttgttt  gtggagaca  ggaccatag  tttgaatat  gccatggtc  tattgcagt  4440
ctggcaaac  gcagtgacc  ttccacggg  ccagagagt  ctcatcctt  gccagcaaa  4500
atgcacaac  ataactatg  tggtaactt  caggaaaat  cgagtggcc  cagcctcat  4560
catggacag  cctggactt  tcctgccca  ggacctgga  attcacaag  atacagggg  4620
catattagc  catcaactg  cagaggcag  ggcagaggg  taccatact  agtatctgt  4680
tttcctcag  cacatcatt  ttatctgga  agacttttc  agctgcaat  taaggcagc  4740
atccaagag  cttgaataa  aataattca  caacagctt  atttttatg  ggagaaggg  4800
cttgcatac  atagtttaa  aaagacaaa  aaaaccttt  cttaaattc  tgctgttct  4860
aaaactaga  cgattgtac  tcttcacaa  ttctagtta  caattttat  ttgtattct  4920
gcagtttta  gtggatgct  attttaggg  cataagcct  ttatggccc  cttgcagat  4980
ttctgaact  tgcacattt  tgctttttt  gtaagtttg  accaacttt  atgtaacaa  5040
cagcccctc  ccacctcca  ttttacaac  atcagaaag  gcactgatt  atttggtat  5100
tttcttttt  caaagctac  tttagtcaa  ggtcactgt  agtctttgc  cctgctttc  5160
gtgttattg  gaaaggtgt  ctttgtgct  atttcagaa  ataaaacac  acctttctc  5220
tgatgcaac  gttttataa  aaaaaa  5246



<210> 5253
<211> 418
<212> PRT
<213> Homo sapiens
<308> Q14004
<400> 5253

Met Leu Pro Glu Asp Lys Glu Ala Asp Ser Leu Arg Gly Asn Ile Ser 
  1               5                  10                  15
Val Lys Ala Val Lys Lys Glu Val Glu Lys Lys Leu Arg Cys Leu Leu 
             20                  25                  30
Ala Asp Leu Pro Leu Pro Pro Glu Leu Pro Gly Gly Asp Asp Leu Ser 
         35                  40                  45
Lys Ser Pro Glu Glu Lys Lys Thr Thr Thr Gln Leu His Ser Lys Arg 
     50                  55                  60
Arg Pro Lys Ile Cys Gly Pro Arg Tyr Gly Glu Thr Lys Glu Lys Asp 
 65                  70                  75                  80
Ile Asp Trp Gly Lys Leu Cys Val Asp Lys Phe Asp Ile Ile Gly Ile 
                 85                  90                  95
Ile Gly Glu Gly Thr Tyr Gly Gln Val Tyr Lys Ala Arg Asp Lys Asp 
             100                105                110
Thr Gly Glu Met Val Ala Leu Lys Lys Val Arg Leu Asp Asn Glu Lys 
         115                120                125
Glu Gly Phe Pro Ile Thr Ala Ile Arg Glu Ile Lys Ile Leu Arg Gln 
     130                135                140
Leu Thr His Gln Ser Ile Ile Asn Met Lys Glu Ile Val Thr Asp Lys 
 145                150                155                160
Glu Asp Ala Leu Asp Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val 
                 165                170                175
Phe Glu Tyr Met Asp His Asp Leu Met Gly Leu Leu Glu Ser Gly Leu 
             180                185                190
Val His Phe Tyr Glu Asn His Ile Lys Ser Phe Met Arg Gln Leu Met 
         195                200                205
Glu Gly Leu Asp Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile 
     210                215                220
Lys Cys Ser Asn Ile Leu Leu Asn Asn Arg Gly Gln Ile Lys Leu Ala 
 225                230                235                240
Asp Phe Gly Leu Ala Arg Leu Tyr Ser Ser Glu Glu Ser Arg Pro Tyr 
                 245                250                255
Thr Asn Lys Val Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu 
             260                265                270
Gly Glu Glu Arg Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys 
         275                280                285
Ile Leu Gly Glu Leu Phe Thr Lys Lys Pro Ile Phe Gln Ala Asn Gln 
     290                295                300
Glu Leu Ala Gln Leu Glu Leu Ile Ser Arg Ile Cys Gly Ser Pro Cys 
 305                310                315                320
Pro Ala Val Trp Pro Asp Val Ile Lys Leu Pro Tyr Phe Asn Thr Met 
                 325                330                335
Lys Pro Lys Lys Gln Tyr Arg Arg Lys Leu Arg Glu Glu Phe Val Phe 
             340                345                350
Ile Pro Ala Ala Ala Leu Asp Leu Phe Asp Tyr Met Leu Ala Leu Asp 
         355                360                365
Pro Ser Lys Arg Cys Thr Ala Glu Gln Ala Leu Gln Cys Glu Phe Leu 
     370                375                380
Arg Asp Val Glu Pro Ser Lys Cys Leu His Gln Ile Ser Leu Tyr Gly 
 385                390                395                400
Lys Ile Val Met Ser Tyr Gly Val Lys Ser Glu Glu Asp Arg Ser Arg 
                 405                410                415
Trp Ala 
             420



<210> 5254
<211> 596
<212> DNA
<213> Rattus norvegicus
<308> AA875127
<400> 5254

ttttttttt  tttttttca  tattgtatg  aagaccctt  ccacataaa  ataaagctg  60
tgttgaatt  atattattc  agtctcttg  attgctgcc  gaaattgca  ctagaaaag  120
ctttccaga  aaaaatgat  tgcctgagg  aaaacagat  ctcagtatg  taaccctct  180
cctcgacct  tgccagctg  tgtgctaat  tgtcccctg  atccttgtg  gtatccagg  240
ccttgggca  gagaagtcc  ggtctgtcc  tgcatgagg  tggggccac  tggattttc  300
tgtaagtta  caccatagt  atagttgtg  atctttgct  gcaaggggt  agtactctc  360
ggccctgtg  aagggtcac  gctgtttgt  aggaccgtg  taggaccat  gctgtactc  420
aatctatgg  ccttgtctc  actaaacag  atgggacca  cattgaggt  aatgtctcc  480
tatccagct  ctgaactgg  aaatgactc  gtgaaggca  aagtctgag  tggaccacc  540
gtgtgagat  aagtagtac  gtagttatc  agagactga  tatctgagt  tccgat  596



<210> 5255
<211> 135
<212> PRT
<213> Rattus norvegicus
<308> BAB26250
<400> 5255

Met Glu Thr Phe Thr Ser Met Leu Val Pro Cys Cys Leu Val Glu Thr 
  1               5                  10                  15
Arg Thr Ile Asp Leu Asn Ile Ala Met Val Leu Ser Gln Ser Ser Gln 
             20                  25                  30
Thr Ala Met Thr Leu Pro Gln Gly Gln Arg Val Leu Ile Pro Cys Gln 
         35                  40                  45
Gln Arg Cys Thr Thr Ile Thr Met Val Val Thr Tyr Arg Lys Ile Gln 
     50                  55                  60
Val Ala Leu Ala Ser Cys Met Asp Arg Pro Gly Leu Leu Leu Pro Lys 
 65                  70                  75                  80
Asp Leu Asp Ile His Lys Asp Thr Gly Asp Thr Leu Ala His Gln Leu 
                 85                  90                  95
Ala Glu Val Glu Ala Glu Gly Tyr His Thr Glu Tyr Leu Phe Phe Leu 
             100                105                110
Arg His Ile Ile Phe Ile Trp Lys Asp Phe Ser Ser Cys Asn Phe Arg 
         115                120                125
Gln Gln Ser Lys Arg Leu Glu 
     130                135



<210> 5256
<211> 5246
<212> DNA
<213> Homo sapiens
<308> NM_003718
<400> 5256

ggcgctttt  ccggccggc  ctggtgctc  gtgtccctc  gccgccgct  ccgtttccg  60
cgggggaga  ggccaggat  tgacccggg  ggaggccgc  cccgcgccg  gctctgcgg  120
tggctctag  cgatgccga  cagctcgga  acggcgctg  ggggaggcg  gggcctgag  180
tgggcggag  agaggttgg  ggaacgccg  aagcggagg  gattcctgt  ccctcagca  240
ccgccgctg  tgttgccgc  cctgcagcc  cagctcctg  aaccgccgc  gcccccgcc  300
cctctgctc  tcctggctg  tcccggcac  gccgccgcc  cagccgccg  cgccgcggc  360
tcctcctct  gcttcagcc  gggcccccc  ctggaggtc  agcggctgg  gagaggcaa  420
aggcgcgca  gagggcggc  gaagcggcg  cgcgggccc  gcgccgggc  ggaggcgga  480
aagcgtcgg  tcttctcgc  gccccagcc  cagcaggac  gcggtggcg  tgctagtag  540
ggcgggggt  tgaccccgc  ggtggaata  gaggatgtg  gctcccagt  cgagcaggg  600
ctgctgctg  ggggggcca  cgcggcaac  gcggcgacg  ctgccgggg  aacgggggg  660
agcggcggg  gtccggcct  ctcctccgg  acccagcgg  gcggggagg  gtcggagcg  720
aggccccgc  gggaccgcc  cagcagcag  ggccgcagc  aagagcgcc  ccgcgagca  780
cggcggcgg  atgggcagc  cggtggcag  gaggcctcc  agtcccgca  ccgccacag  840
cacagcggc  aggaacggg  cgaggtcgc  aagagcggc  gcagcagca  cagcggcgg  900
cgccggaaa  gcgcttcgg  cacatccag  agcagtagc  gccgcaagg  ccgggactc  960
aaggcccac  gcagccgga  taagtcgtc  aaggagccg  cttcggcct  caaggaacc  1020
cccaaggcc  accgggagg  caagaccga  cctaaggcc  acaggcggc  gcggtccct  1080
agcccactg  gaggccggg  cgacagccc  gtgtcccac  gggcctctc  gagcctgag  1140
agccgcaag  cccccagcc  ggcaggagg  ggcagcagc  cctattctc  gcggctgcc  1200
cgctccccg  gcccctaca  tcgccgccg  tcccccagc  acagccgcc  cagctccta  1260
gagcggggc  gcgacgtgt  ccctagtcc  tacagcagc  gcagctggc  ccgctctcg  1320
agtccctac  gccctgtgc  cagacggtc  ggaaaatcc  gaagcagaa  cccgtattc  1380
tctaggcat  caagatctc  tagcaggca  agattgtct  gatccagaa  tcgtcattc  1440
agtatttct  ctagcacac  aactctgaa  agtagcctg  cagctgaat  gaacaagaa  1500
aaaaaagca  gagcagcag  ggcagcaag  gccgcagaa  cagcgaaag  tgcagaagc  1560
actaaggct  ctgaggctg  tgccaaggc  gcaaaagct  caaacactt  tacacctac  1620
aaggggaac  cggaaacta  tgccagtgc  tcacaaaca  accatgtga  ggatgtgaa  1680
aaaattaaa  ttgaacatg  accttctcc  tcaagtggt  gaactttaa  aaatgacaa  1740
gcaaaaaca  agccacctc  tcaggtaac  aaggtggaa  ataatttga  tgtagataa  1800
gccaccaag  aagcagtca  agttggaaa  gagagtaaa  ctgctgcta  aaaggagga  1860
tcagtatct  ttaaagaga  aaccaaacc  cttacacca  gcataggag  caaggagaa  1920
gagcaacat  tagctttag  cacctctac  ttaccaccg  tacctttgc  tcccatgct  1980
cctgaagat  aagaagctg  tagcttacg  ggaaatatt  cagtaaaag  agttaaaaa  2040
gaagtagaa  agaaactcc  atgtcttct  gctgattta  cgctgcccc  tgagctacc  2100
ggaggagat  atctttcaa  gagtccaga  gaaaagaaa  caacaacac  gttacatag  2160
aaaaggagg  ctaaaatat  tgggcctcg  tatggtgaa  ccaaagaaa  agatattga  2220
tggggaaaa  tctgcgtgg  taaatttga  atcatcgga  ttattggag  aggtactta  2280
ggacaagtt  acaaagcca  ggataaaga  actggagaa  tggtagcct  aaaaaaagt  2340
cgtctggat  atgaaaagg  aggctttcc  attacagca  ttcgagaaa  taaaattct  2400
cggcagctt  cccatcaga  tattatcaa  atgaaggaa  tagtgactg  taaagaaga  2460
gctttggat  tcaagaagg  caaaggtgc  ttttatctg  tgtttgaat  tatggacca  2520
gatctgatg  gactactgg  atcaggctt  gttcatttt  atgaaaatc  cataaagtc  2580
tttatgaga  agctcatgg  gggtctgga  tattgtcat  agaagaact  tttgcatag  2640
gatattaaa  gttccaata  ccttctaaa  aatagaggg  agataaaac  tgcagactt  2700
ggacttgct  gattgtata  ctcagaaga  agtcggccg  atactaaca  ggtaattac  2760
ttatggtac  gtccacctg  actgctact  ggagaagaa  gatacacac  agccattga  2820
gtatggagc  gtggctgta  ccttggcga  ctcttcact  aaaaaccta  atttcaagc  2880
aatcaggaa  ttgcacaac  agaattaat  agccgaata  gtgggagtc  atgtcctgc  2940
gtgtggcct  atgtaatca  actaccata  ttcaacacc  tgaaaccaa  gaagcaata  3000
cgtcgaaag  taagagaag  atttgtttt  attcctgca  ctgcgctag  cttatttga  3060
tacatgctt  ccttggatc  tagtaagcg  tgcactgct  aacaggctc  tcagtgcga  3120
ttcctccga  atgtggaac  ctcaaaaat  cctccacca  atctccctt  atggcaaga  3180
tgtcatgag  tatggagta  aaagcgaag  agacagaag  agatgggca  gactgatga  3240
gtttccaca  ttaaagccc  caggaagga  ttgtctctg  gcttggatg  cagcagaac  3300
aacacaccc  agggtgtgc  gccatcttc  cagctgaaa  ctcagggca  ctcaaatgt  3360
gcacctgta  aaacaggcc  tggacagca  ttaaaccac  gtgaattgg  aattctact  3420
aacctacta  aatctaaaa  aagtgttaa  atggctgat  ttgtccaag  gttgaacat  3480
aaggtaaac  ctgagactc  acagcagct  aataaaata  accttcctg  tggaatttt  3540
gcaacaggt  aaaaacaga  agatccatc  acaccacaa  aggagtctt  gaaaccgtt  3600
ggaggaatt  agccttctt  tcagaccat  cagcctaaa  tggagactg  tgctgccca  3660
gcggctgtg  agagtgcat  tgcagttct  ttgactcag  taataaagg  tcagcagtc  3720
aagcagaaa  atgtgctac  agaagagag  gaaaatgga  cgggacatg  agcgtcatt  3780
caactcagg  cacctccag  acctagcac  ccggtgtcg  gacaagatg  cctcatcca  3840
catcaagat  tgaggatct  ggagctaac  ccagaacca  accggcctc  aattctgcc  3900
cctgaccaa  gacctcccg  gcctcctga  ccaccacca  tcactgagg  agatctaga  3960
tatcggaca  aaaaccagc  tgtacccac  accagttct  cattaactg  ccctcatgc  4020
ggagtgaag  cagccctgt  acagctgct  gctcagcat  agccccagg  tgaccccaa  4080
agagaaggt  ggattgatt  tcaagcagg  gacacttac  tgtccactt  agactacaa  4140
gacaacttt  gatcctctt  tttctcttc  gctccttat  ttagcaatg  tggtctagg  4200
agcagttct  ctccaccac  agaacgacg  agtttcatt  gaaattcag  tattcagtc  4260
ttggataac  acagtactg  ttcatctca  tctggtggt  cacctcagc  ttctgcctt  4320
tctgagtca  ttcccagtt  agtagctgg  tatggagac  tttacctca  tgctggtcc  4380
atgttgttt  gtggagaca  ggaccatag  tttgaatat  gccatggtc  tattgcagt  4440
ctggcaaac  gcagtgacc  ttccacggg  ccagagagt  ctcatcctt  gccagcaaa  4500
atgcacaac  ataactatg  tggtaactt  caggaaaat  cgagtggcc  cagcctcat  4560
catggacag  cctggactt  tcctgccca  ggacctgga  attcacaag  atacagggg  4620
catattagc  catcaactg  cagaggcag  ggcagaggg  taccatact  agtatctgt  4680
tttcctcag  cacatcatt  ttatctgga  agacttttc  agctgcaat  taaggcagc  4740
atccaagag  cttgaataa  aataattca  caacagctt  atttttatg  ggagaaggg  4800
cttgcatac  atagtttaa  aaagacaaa  aaaaccttt  cttaaattc  tgctgttct  4860
aaaactaga  cgattgtac  tcttcacaa  ttctagtta  caattttat  ttgtattct  4920
gcagtttta  gtggatgct  attttaggg  cataagcct  ttatggccc  cttgcagat  4980
ttctgaact  tgcacattt  tgctttttt  gtaagtttg  accaacttt  atgtaacaa  5040
cagcccctc  ccacctcca  ttttacaac  atcagaaag  gcactgatt  atttggtat  5100
tttcttttt  caaagctac  tttagtcaa  ggtcactgt  agtctttgc  cctgctttc  5160
gtgttattg  gaaaggtgt  ctttgtgct  atttcagaa  ataaaacac  acctttctc  5220
tgatgcaac  gttttataa  aaaaaa  5246



<210> 5257
<211> 418
<212> PRT
<213> Homo sapiens
<308> Q14004
<400> 5257

Met Leu Pro Glu Asp Lys Glu Ala Asp Ser Leu Arg Gly Asn Ile Ser 
  1               5                  10                  15
Val Lys Ala Val Lys Lys Glu Val Glu Lys Lys Leu Arg Cys Leu Leu 
             20                  25                  30
Ala Asp Leu Pro Leu Pro Pro Glu Leu Pro Gly Gly Asp Asp Leu Ser 
         35                  40                  45
Lys Ser Pro Glu Glu Lys Lys Thr Thr Thr Gln Leu His Ser Lys Arg 
     50                  55                  60
Arg Pro Lys Ile Cys Gly Pro Arg Tyr Gly Glu Thr Lys Glu Lys Asp 
 65                  70                  75                  80
Ile Asp Trp Gly Lys Leu Cys Val Asp Lys Phe Asp Ile Ile Gly Ile 
                 85                  90                  95
Ile Gly Glu Gly Thr Tyr Gly Gln Val Tyr Lys Ala Arg Asp Lys Asp 
             100                105                110
Thr Gly Glu Met Val Ala Leu Lys Lys Val Arg Leu Asp Asn Glu Lys 
         115                120                125
Glu Gly Phe Pro Ile Thr Ala Ile Arg Glu Ile Lys Ile Leu Arg Gln 
     130                135                140
Leu Thr His Gln Ser Ile Ile Asn Met Lys Glu Ile Val Thr Asp Lys 
 145                150                155                160
Glu Asp Ala Leu Asp Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val 
                 165                170                175
Phe Glu Tyr Met Asp His Asp Leu Met Gly Leu Leu Glu Ser Gly Leu 
             180                185                190
Val His Phe Tyr Glu Asn His Ile Lys Ser Phe Met Arg Gln Leu Met 
         195                200                205
Glu Gly Leu Asp Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile 
     210                215                220
Lys Cys Ser Asn Ile Leu Leu Asn Asn Arg Gly Gln Ile Lys Leu Ala 
 225                230                235                240
Asp Phe Gly Leu Ala Arg Leu Tyr Ser Ser Glu Glu Ser Arg Pro Tyr 
                 245                250                255
Thr Asn Lys Val Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu 
             260                265                270
Gly Glu Glu Arg Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys 
         275                280                285
Ile Leu Gly Glu Leu Phe Thr Lys Lys Pro Ile Phe Gln Ala Asn Gln 
     290                295                300
Glu Leu Ala Gln Leu Glu Leu Ile Ser Arg Ile Cys Gly Ser Pro Cys 
 305                310                315                320
Pro Ala Val Trp Pro Asp Val Ile Lys Leu Pro Tyr Phe Asn Thr Met 
                 325                330                335
Lys Pro Lys Lys Gln Tyr Arg Arg Lys Leu Arg Glu Glu Phe Val Phe 
             340                345                350
Ile Pro Ala Ala Ala Leu Asp Leu Phe Asp Tyr Met Leu Ala Leu Asp 
         355                360                365
Pro Ser Lys Arg Cys Thr Ala Glu Gln Ala Leu Gln Cys Glu Phe Leu 
     370                375                380
Arg Asp Val Glu Pro Ser Lys Cys Leu His Gln Ile Ser Leu Tyr Gly 
 385                390                395                400
Lys Ile Val Met Ser Tyr Gly Val Lys Ser Glu Glu Asp Arg Ser Arg 
                 405                410                415
Trp Ala 
             420



<210> 5258
<211> 598
<212> DNA
<213> Rattus norvegicus
<308> AA875135
<400> 5258

ttttttttt  tttttttat  acaaaatca  atatattca  atggtttct  ttacggcca  60
ttttaccaa  atatcaaga  aagataaac  actttcaaa  ttagtatca  aacaggaca  120
tttaaatct  cccacatgt  cagaggtat  atctttgtt  ttttcaaag  tgagcacag  180
gaggttgga  gagacgttt  cttattaac  cctgaaacc  caggacttg  tgagttctg  240
cctatgaca  gtgaactgt  agcatggta  tcaggggac  ctccggatt  agacctcat  300
aatactgtt  acgacagct  tgatagttc  tatattaat  tttttactc  gtaataatt  360
tgtttttat  tacaagtac  caggtatga  attatttga  tctaaaata  ttaaaaacc  420
aaaaaaaaa  aaaaccaac  aaacaaaca  aaaaaacca  accccaaat  cctcatatt  480
tgtaaatgt  gtagtttca  gctttctta  gtcatgtca  tacctgact  cactaagac  540
actttaaca  tggagtaaa  gctttaaac  tctaattaa  aataaattc  agccaata  598



<210> 5259
<211> 179
<212> PRT
<213> Rattus norvegicus
<308> P51646
<400> 5259

Met Gly Ile Leu Phe Thr Arg Ile Trp Arg Leu Phe Asn His Gln Glu 
  1               5                  10                  15
His Lys Val Ile Ile Val Gly Leu Asp Asn Ala Gly Lys Thr Thr Ile 
             20                  25                  30
Leu Tyr Gln Phe Ser Met Asn Glu Val Val His Thr Ser Pro Thr Ile 
         35                  40                  45
Gly Ser Asn Val Glu Glu Ile Val Val Asn Asn Thr Arg Phe Leu Met 
     50                  55                  60
Trp Asp Ile Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr 
 65                  70                  75                  80
Tyr Thr Asn Thr Glu Phe Val Ile Val Val Val Asp Ser Thr Asp Arg 
                 85                  90                  95
Glu Arg Ile Ser Val Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His 
             100                105                110
Glu Asp Leu Arg Lys Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp 
         115                120                125
Val Lys Glu Cys Met Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu 
     130                135                140
Thr Ser Ile Lys Asp His Gln Trp His Ile Gln Ala Cys Cys Ala Leu 
 145                150                155                160
Thr Gly Glu Gly Leu Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu 
                 165                170                175
Lys Ile Arg 
             180



<210> 5260
<211> 1281
<212> DNA
<213> Homo sapiens
<308> AF100740
<400> 5260

tcagcctga  ccgggggaa  ccaggcggc  cgggtgtct  gaggggggg  ggtccgctg  60
ccgagaatg  gaattctct  cactagaat  tggagactg  tcaatcacc  ggagcacaa  120
gttatcatt  ttgggctgg  taatgcagg  aaaactacc  ttctttacc  attttctat  180
aatgaagtt  tacatacat  tcctacaat  ggaagtaat  tagaagaga  agtgattaa  240
aatacacgt  tcctaatgt  ggatattgg  ggccaagaa  ctcttcgtt  ttcctggaa  300
acttactat  ctaacacag  gtttgtaat  gttgttgtg  acagtacag  cagagagag  360
atttctgta  ctagagaag  actctataa  atgttagcg  atgaggacc  aagaaaagc  420
ggattgctg  tttttgcta  taaacaaga  gttaaagaa  gcatgactg  agcagaaat  480
tcccagttt  tgaagctaa  ttctattaa  gatcaccag  ggcatatcc  ggcatgctg  540
gctctaact  gcgagggat  gtgccaagg  cttgaatgg  tgatgtcac  acttaagat  600
agatgatct  tactgacct  ttctcatag  ttttgtata  atgaagtgc  ggactttac  660
tgaaagctg  aaaaattaa  ggtttagat  tatttataa  aaactgatt  aaacttttt  720
tataagaag  aaaattaag  ccacttatt  gaaaacaaa  atgaagtct  accttccag  780
ttgctttct  attagtttt  tccaaagta  gttattgaa  ctgtgattg  catttttct  840
ataatgaat  ctctcagga  attgtgtag  ctatggtaa  tacaaaggg  gaggaagac  900
ttttgaatt  taagagctt  attatcagt  taaccctcc  tagttgaat  ttattttct  960
cttgttcca  taagtcaga  tacaaatca  cacagatat  cgaatgttt  caatatttt  1020
aaatgtaat  ttacttatg  aaagtattt  gcttaaggt  gtgtgtgta  tgtgtatat  1080
cctcaagtt  aagttaatg  cattgattt  tgttccaga  aaaaataac  caaataata  1140
tatccttcg  tataaccac  atgagataa  tattggcat  agtgttcag  gccatttta  1200
actttctct  tgtgttctc  gtattgtac  aaccaacct  ccaaatcgc  gagctgctt  1260
tttaaaaaa  aaaaaaaaa  a  1281



<210> 5261
<211> 179
<212> PRT
<213> Homo sapiens
<308> Q9Y689
<400> 5261

Met Gly Ile Leu Phe Thr Arg Ile Trp Arg Leu Phe Asn His Gln Glu 
  1               5                  10                  15
His Lys Val Ile Ile Val Gly Leu Asp Asn Ala Gly Lys Thr Thr Ile 
             20                  25                  30
Leu Tyr Gln Phe Ser Met Asn Glu Val Val His Thr Ser Pro Thr Ile 
         35                  40                  45
Gly Ser Asn Val Glu Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met 
     50                  55                  60
Trp Asp Ile Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr 
 65                  70                  75                  80
Tyr Thr Asn Thr Glu Phe Val Ile Val Val Val Asp Ser Thr Asp Arg 
                 85                  90                  95
Glu Arg Ile Ser Val Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His 
             100                105                110
Glu Asp Leu Arg Lys Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp 
         115                120                125
Val Lys Glu Cys Met Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu 
     130                135                140
Thr Ser Ile Lys Asp His Gln Trp His Ile Gln Ala Cys Cys Ala Leu 
 145                150                155                160
Thr Gly Glu Gly Leu Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu 
                 165                170                175
Lys Ile Arg 
             180



<210> 5262
<211> 487
<212> DNA
<213> Rattus norvegicus
<308> AA875147
<400> 5262

ttttttttt  tttttttaa  tttgttaaa  gccactttt  tttacagtt  gcgctttac  60
cctgagagt  attatcaag  aggcagctt  tttcttttc  aacatctca  aacatacac  120
cctctttgc  ggcttcatc  tactgcaca  tatatagat  ctcaccaca  atatgtgca  180
acacacaga  acacacggg  acacgcacc  ctgcacatg  tggtaacat  tgcaaccta  240
acctttttg  ttgctctcc  cattcatgt  gaattattt  ataaaaacc  gaacaaagt  300
ttattcttg  caaacatcg  agtcactag  aagagagag  aacagtggg  ggggacgag  360
tgtgctacg  tcagtcaag  agccacagc  gtgcctggg  actgatcga  actctggct  420
cccccctgg  ccttgccat  agtttcctg  ccacctgtc  gaacacagc  tatggggca  480
ggggggt  487



<210> 5263
<211> 4404
<212> DNA
<213> Homo sapiens
<308> D87440
<400> 5263

gtcgagcag  ggcggcggc  gcggcagtg  cggtcccac  ggcaggcgg  caagagggg  60
gtccgggcg  cggccggcg  gggagccgg  ggaccacca  ggtaaagaa  cggaaaggc  120
gcgtcgtga  cgactcgga  acagaggac  gcggcagcg  cgagaacct  gatcaggag  180
tcttgtccc  ggcaaagcg  aagcgcagt  actctgagg  gaaggagcc  cctgtgagt  240
agcctgcag  ctcgtcaga  tcggagacg  ctgacagtg  cgatgagtg  acatttggg  300
gcaataaaa  taagaagaa  ggaaaagcc  gaaaaatag  gaagaaagg  accatgaag  360
aacaggcca  caaaactgc  tcctcaggc  gttcagaca  agacagttc  gctgagagc  420
cagcccctg  ggaaggtga  gtgtcagac  ctgacagca  cagctcctc  tccagttca  480
attcagact  ttcctcaga  gatgaagag  tccatgatg  ctatggaga  gacctcatg  540
gagatgagg  agacagggc  cgtctggaa  agatgacag  gaaagagag  gagcaagaa  600
tgttcaatc  catagagaa  agggaggtg  tgaaaagaa  atttgaaat  aagaaaaaa  660
taaaaacag  caaaaagaa  gaaaagaaa  aaaagaaga  aaagcaaga  gaggagcaa  720
aaaagaaaa  actgacaca  attcaagaa  ctcaggtaa  atcccacaa  aaggaacgg  780
gttccaagc  ggatgagaa  ctagacaag  aatctcaag  catggagga  ctaaaagca  840
agcgagaaa  acgaaagaa  agaacagct  agctccttg  caaaaaaca  ccattaaaa  900
ccagtgagg  ctactctga  gatgaagag  aggaagagg  tgacaaatc  agtgaaaag  960
cagaccgct  atcacgaac  tcatcgtct  atgaagaag  ggagaaaga  gagatccct  1020
ccaaatccc  accagtttc  ttacctgaa  aattgaatc  ggttcgatt  tcacggcat  1080
agctagaac  ctggtgtca  atgcccttc  ttgctaaaa  tgtcacagg  tgttttgtg  1140
ggattggca  cggaaacca  aacagcaaa  cagtttacc  ggtcgctga  attacgggt  1200
ttgtggaaa  tgccaaagt  taccaacta  gtggcacca  aacaaacaa  gggctgcaa  1260
tacggcatg  caatgacca  cgcgtgttc  gtttagagt  tgtctcaaa  caagaattc  1320
ccgaaagtg  gtttatgaa  tggaaagaa  cgatgttct  tgctggcat  cagttgccc  1380
ctctagatg  aatcaataa  aaggaatta  ctattaaag  agctcttaa  tataaattc  1440
atgatcagg  cattgaaga  attgtaaaa  agaaagaaa  gttcagaaa  gctccaccc  1500
actacgcta  gaagaagac  cagctactg  aggaaaagg  catggctga  gacctgggg  1560
atcaggaca  ggccaaaca  atccaagat  aactgaatg  gctggagga  cgggcagag  1620
ccctggacc  ccagcggac  aagaacata  ccgctatca  ttacatcaa  cagcggaac  1680
gggagtgga  cattgtaga  tctgagaag  cccttgtgg  tgaaagtca  aacatgaaa  1740
accaacaga  ggatccctt  actcggcgg  agtgcaagc  taccatcgt  tctaattcc  1800
gagacccag  tgttcaagc  gccatcttg  cccagctga  tgcaaaata  ggttctgga  1860
tgttaccag  tgctccaaa  gaaatgagc  agggtcaag  caaagataa  gatttgaat  1920
ctaagtcag  cagtgacct  tcagaagat  tgttcaaag  acacgattt  gatgtgaag  1980
ttgacttac  agttcccag  tcagagtca  aggctttag  catcacctc  aaggctccg  2040
cagccaagg  tggggctcc  aggagatct  tgaacttgg  agactacaa  aaacgacga  2100
ggcttattt  agcacaccc  gcctgctgc  tctgaccct  catgcccca  cgcagcgtc  2160
cacctttcc  cctttcctt  gatttagcc  ctttgggct  gagcagctg  tgaactggg  2220
agagactct  aactgccag  catctgtaa  ataaaccat  tgctgtata  acctccttt  2280
tctgcacac  atctcccac  agcctcccc  cccccaggg  cccacccag  gtgggcctg  2340
gctctcttg  gctttatcc  tgtctttag  tttgtgttt  ccttttgtt  ttttaaccg  2400
gcagttcat  ggccactct  cacgcattc  gtattacca  ggagctggg  atcttgctg  2460
agcccctgg  gcaatagca  cagcaccag  cggtctcct  tacagactg  cttggccca  2520
ccattgaac  ttcggcacg  gaccttgtg  ggggagcgg  gattgggca  ctgcgatcc  2580
ctttcctct  ttcatcttt  tcttctgcc  ttctttttg  aagaagggg  ttcaaaacc  2640
gtttagttt  caaaaagtg  acatttgtg  ggggggggg  tctaatttg  gagcgagag  2700
gtgtatgtg  gtgtgtgta  gtgtgtgga  ttttttatc  tttttttaa  atgcagtac  2760
ctttgtatc  gtctgtcat  ggtctatag  tgtttcaga  ttttttcag  tgtacttga  2820
catctgaaa  tgcaagaaa  aaactcatt  aatgtgatt  ttcttacta  acaggcctg  2880
ctgctgtag  tgtgtaact  ccccattcc  acctactct  cccatcctt  cccaacttt  2940
gagaaaact  cccagttta  ccccctgac  tgcaggctg  gtcctggca  gtgtgggag  3000
gaagcccat  gccaggtac  agggagggc  gtgaatgtc  tgctcttcc  atgggtaca  3060
cccacagct  cttggctga  cgtagaact  ctttttctc  cccagtata  cagcctctt  3120
ctggtgatt  tgttttgct  ctttggcaa  aactacatt  tgtttttaa  agaaatttc  3180
gaatatgaa  gtggagagc  aacacaaaa  gatttaggt  acgccgggt  cagtagctc  3240
cgcctgtaa  cccagcact  tgggaggcc  aggcgggtg  atcacctga  gtcaggagt  3300
caagaccaa  ctgactaac  cggtgaaac  ccatctcta  taaaactac  aaacttagc  3360
gggcatggt  gtgcgtgcc  gtaatccca  ctactcggg  ggctgagac  ggagaatcc  3420
ttgaacctg  gaggcggag  ttgtggtga  ccaagatcg  gccactgca  tccagtctg  3480
gtgacagag  gagactccg  ctcaaaaag  tttaggttg  aaatgtttc  agcatgtgc  3540
gttttgtgt  tgtgtatac  tatatatgg  cagcatata  attgtgcag  tagggcgaa  3600
ccagcagag  tgtgtgtat  tctttatga  atgtttgaa  agagataag  tgactgctt  3660
ataatcact  tcaggtgta  agctccaag  gtaaataaa  gtggcattt  acaaatctt  3720
cagaacaaa  tacagctga  tatatatac  aagagctaa  ctaaaggaa  agctgagag  3780
tccgatctc  acgagagac  aatctaaaa  ctctgcttt  tacttcctc  ccctgcttt  3840
gtacaagga  gggggacga  gggaaatca  ggacttgta  gttgtattt  aacataaaa  3900
tgaacttgg  aacttctgg  tttagtaga  cctcagtgt  gctttaact  agtttactt  3960
ttttttatt  ttaaagcag  aatggatgg  tttaaagga  tattatgat  gtaaaattg  4020
taaatatga  tgtaacaca  ctttgtggt  gctgtgaca  agttcactt  ggcaaagga  4080
tggtgatgg  ctcgttaaa  tcatatata  ttgaatagt  cattgaccg  aactcttta  4140
agactattg  gtaaatgtg  aatcacaga  tgttaacat  gcctggact  cagcagagt  4200
ctggagctg  tgggacctc  cctatcatg  tgaacttgg  ctttttttt  tgatttctg  4260
ttttaaaaa  cataaaatt  tagaatcca  ataattcgc  ggagtcatt  tgatccacc  4320
tgtagatct  tatttagta  catttggat  tggagaagt  ttgattaca  tatggctgt  4380
taataaaat  tttattaaa  ctgc  4404



<210> 5264
<211> 517
<212> DNA
<213> Rattus norvegicus
<308> AA875148
<400> 5264

ttttttttt  tttttttag  attttgact  taaatgttt  aatagaaat  cacaatctt  60
cactttctc  gacagcaac  gagggggtc  taacagcaa  tagaacatg  ggttttgca  120
agggataca  catagctga  tgcaaagct  aactgctag  tttgcccca  agtcagtgg  180
aggagcgcc  gaaggtgac  caaaaaccg  tgacagaag  tgcagacct  gaaaatact  240
gggtgagat  aggtgtgtc  aagcagcca  tttagtgct  atccactct  ggctcattt  300
aaccacaca  gatgggagc  tccaccctc  agctctttt  ttctcatgt  acttcacca  360
ttggttaca  ggaatgtgg  gaagagact  aagacctct  gtggtggcc  taagatgtg  420
attctgaac  agttcctct  tggggggct  cctgcanga  tcctggtga  ttgcaagct  480
aggttccta  tacatacag  ttttaccaa  aacaaaa  517



<210> 5265
<211> 544
<212> DNA
<213> Rattus norvegicus
<308> AA875192
<400> 5265

cagccgcct  gcccggttt  caaacccgg  gaaaccaac  ctgaaaccc  acaagcctc  60
tatcttacc  aatcgcttt  ggaaccgac  ccgaaagaa  ggcaaggca  cttgtatca  120
ggagatgtc  atgatgatg  cttgctgga  gcagaatga  ttccgcgac  aggcgtgca  180
gaaagagat  caggacttc  tcgattgtt  ttccaaggc  caagaagct  ggaagatga  240
atcaatcca  gagactctg  gacagtctg  aagtttacc  ccccacaaa  tgactaagt  300
gttacagag  tttcccaat  aatctcatc  gagctgaaa  tggagaaac  ttttcaacg  360
actctcatt  ctgaaagct  cacagaggc  tattaggga  gtttgcatg  attgccatg  420
gtttttgaa  ggtaaaatg  ggcaaaaca  tcaattttg  tcttctgaa  gaatcgtgt  480
ctggatacg  gtcttgaaa  aaaaccctc  aaaaagaaa  aataaaaaa  aaaacccct  540
gtgc  544



<210> 5266
<211> 118
<212> PRT
<213> Rattus norvegicus
<308> NP_079642
<400> 5266

Met Ala Thr Pro Ser Leu Arg Gly Arg Leu Ala Arg Phe Ala Asn Pro 
  1               5                  10                  15
Gly Lys Pro Ile Leu Lys Pro Asn Lys Pro Leu Ile Leu Ala Asn Arg 
             20                  25                  30
Val Gly Asn Arg Arg Arg Glu Lys Gly Glu Ala Thr Cys Ile Thr Glu 
         35                  40                  45
Met Ser Met Met Met Ala Cys Trp Lys Gln Asn Glu Phe Arg Asp Glu 
     50                  55                  60
Ala Cys Arg Lys Glu Ile Gln Asp Phe Phe Asp Cys Ser Ser Arg Ala 
 65                  70                  75                  80
Gln Glu Ala Arg Lys Met Arg Ser Ile Gln Glu Ser Leu Gly Gln Ser 
                 85                  90                  95
Glu Ser Leu Ser Pro His Lys Met Thr Lys Leu Leu Gln Arg Phe Pro 
             100                105                110
Asn Lys Ser His Leu Ile 
         115



<210> 5267
<211> 530
<212> DNA
<213> Rattus norvegicus
<308> AA875198
<400> 5267

ttttttttt  tttttttga  attcaaaaa  atagaggaa  tttatttaa  atgttgcag  60
agacatttc  gaaagtaga  atatttatt  acaatcctg  gtaaacaca  ttcatgcag  120
ttttataat  tctttatcc  gtgtaagtt  tagaatgta  tgatttaac  tactttaat  180
aaaaattta  gttgcaaca  aaggcattt  cacaaccat  tgtatatat  attattaag  240
gcaacataa  agacaatat  atgtatagg  aatagagat  gtaaagaat  aatcttgat  300
tagcaaggc  accattcct  catcaacat  agctaactc  acttcactg  cccccctgc  360
tttcagaag  tcataggca  ggacagacc  aagcaactc  accttcatg  agctctcca  420
acatttctg  aactaacct  gaagaagta  agactcttt  aaataatgt  agcacgaca  480
ctcataaac  aaagaaaag  tacaattta  actagtaaa  gagtgaatct  530



<210> 5268
<211> 527
<212> DNA
<213> Rattus norvegicus
<308> AA875206
<400> 5268

ttttttttt  tttttttct  ctttttaat  cctttattc  acataaatt  ctaccagag  60
gctatgttt  aaaagcaag  tagttggac  gatgcagga  aaaaatgtg  tcacccaat  120
agaaaaggt  atgtttaaa  gattacaac  aatgccaag  gtttgacgc  tgcagcggc  180
ttaaccaga  acatcgatt  ccactgttc  aaagacaca  aaacccgca  atcttactg  240
actccacct  cagagactt  ctattggtt  cctttacaa  agcacagaa  cccaatgaa  300
taaagcagg  tattttaaa  atttaagag  cgttatcaa  aataaatta  attttttca  360
gatacagaa  tgctgctat  acggctggg  acccagcaa  ctttcaatg  ccgcattga  420
gtcgccccc  gttgctatc  gtgcttgta  gtttgcttc  cggttcaag  atcccattg  480
actgagctg  tccagatgc  gttgaaatc  gacttctgg  ctctgca  527



<210> 5269
<211> 582
<212> PRT
<213> Rattus norvegicus
<308> BAA92267
<400> 5269

Met Ala Glu Ser Ala Glu Ser Gly Gly Pro Pro Gly Ala Gln Asp Ser 
  1               5                  10                  15
Ala Ala Asp Ser Gly Pro Ala Glu Pro Lys Ile Met Lys Val Thr Val 
             20                  25                  30
Lys Thr Pro Lys Glu Lys Glu Glu Phe Ala Val Pro Glu Asn Ser Ser 
         35                  40                  45
Val Gln Gln Phe Lys Glu Glu Ile Ser Lys Arg Phe Lys Ser His Ile 
     50                  55                  60
Asp Gln Leu Val Leu Ile Phe Ala Gly Lys Ile Leu Lys Asp Gln Asp 
 65                  70                  75                  80
Thr Leu Ser Gln His Gly Ile His Asp Gly Leu Thr Val His Leu Val 
                 85                  90                  95
Ile Lys Thr Gln Asn Arg Pro Gln Asp Asn Ser Ala Gln Gln Thr Asn 
             100                105                110
Thr Thr Gly Asn Ser Val Thr Ser Ser Pro Ala Pro Asp Ser Asn Pro 
         115                120                125
Thr Ser Gly Pro Ala Ala Asn Ser Ser Phe Gly Leu Gly Gly Leu Gly 
     130                135                140
Gly Leu Ala Gly Leu Ser Ser Leu Gly Leu Asn Thr Thr Asn Phe Ser 
 145                150                155                160
Glu Leu Gln Ser Gln Met Gln Arg Gln Leu Leu Ser Asn Pro Glu Met 
                 165                170                175
Met Val Gln Ile Met Glu Asn Pro Phe Val Gln Ser Met Leu Ser Asn 
             180                185                190
Pro Asp Leu Met Arg Gln Leu Ile Met Ala Asn Pro Gln Met Gln Gln 
         195                200                205
Leu Ile Gln Arg Asn Pro Glu Ile Ser His Met Leu Asn Asn Pro Asn 
     210                215                220
Ile Met Arg Gln Thr Leu Glu Leu Ala Arg Asn Pro Ala Met Met Gln 
 225                230                235                240
Glu Met Met Arg Asn Gln Glu Arg Asp Leu Ser Asn Leu Glu Ser Ile 
                 245                250                255
Pro Gly Gly Tyr Asn Ala Leu Arg Arg Met Tyr Thr Asp Ile Gln Glu 
             260                265                270
Pro Met Leu Asn Ala Ala Gln Glu Gln Phe Gly Gly Asn Pro Phe Ala 
         275                280                285
Ser Leu Val Ser Ser Pro Ser Ser Ala Glu Gly Thr Gln Pro Ser Arg 
     290                295                300
Thr Glu Asn Arg Asp Pro Leu Pro Asn Pro Trp Ala Pro Gln Thr Pro 
 305                310                315                320
Gln Ser Ser Pro Ala Ser Gly Ser Thr Gly Ser Thr Thr Asn Thr Val 
                 325                330                335
Ser Thr Ser Ala Gly Asn Ala Thr Ser Thr Pro Ala Gly Gln Gly Thr 
             340                345                350
Ser Gly Pro Asn Leu Val Pro Gly Ala Gly Ala Ser Met Phe Asn Thr 
         355                360                365
Pro Gly Met Gln Ser Leu Leu Gln Gln Ile Thr Glu Asn Pro Gln Leu 
     370                375                380
Met Gln Asn Met Leu Ser Ala Pro Tyr Met Arg Ser Met Met Gln Ser 
 385                390                395                400
Leu Ser Gln Asn Pro Asp Leu Ala Ala Gln Met Met Leu Asn Asn Pro 
                 405                410                415
Leu Phe Ala Gly Asn Pro Gln Leu Gln Glu Gln Met Arg Gln Gln Leu 
             420                425                430
Pro Thr Phe Leu Gln Gln Met Gln Asn Pro Asp Thr Leu Ser Ala Met 
         435                440                445
Ser Asn Pro Arg Ala Met Gln Ala Leu Leu Gln Ile Gln Gln Gly Leu 
     450                455                460
Gln Thr Leu Ala Thr Glu Ala Pro Gly Leu Ile Pro Gly Phe Thr Pro 
 465                470                475                480
Gly Leu Ala Ala Gly Asn Ser Gly Gly Pro Ala Gly Thr Thr Ala Pro 
                 485                490                495
Ser Thr Ala Pro Gly Glu Asp Thr Asn Pro Gln Gly Gly Ala Ala Glu 
             500                505                510
Pro Gly His Gln Gln Phe Ile Gln Gln Met Leu Gln Ala Leu Ala Gly 
         515                520                525
Val Asn Pro Gln Leu Gln Ser Pro Glu Val Arg Phe Gln Gln Gln Leu 
     530                535                540
Glu Gln Leu Ser Ala Met Gly Phe Leu Asn Arg Glu Ala Asn Leu Gln 
 545                550                555                560
Ala Leu Ile Ala Thr Gly Gly Asp Ile Asn Ala Ala Ile Glu Arg Leu 
                 565                570                575
Leu Gly Ser Gln Pro Ser 
             580



<210> 5270
<211> 2354
<212> DNA
<213> Homo sapiens
<308> NM_053067
<400> 5270

ggaggaagc  gtggctgct  cggatgtcg  tgtgagcga  cggcgcctg  acacacggc  60
gctgccgag  gcctgaccc  ggcctgcgc  agagcctgc  ccgagctcc  gggccccac  120
cccgctacg  tggccctgc  cccgttgct  ctgaggcgg  gtgctctgc  ttcttcgct  180
tccaggcct  ccggctctg  tgtctgctg  ctcctcctt  ctcgcctgc  ccctcctgc  240
tgcctgagt  accgccgcc  ccgccgcca  agccatggc  gagagtggt  aaagcggcg  300
tcctccggg  tcccaggat  gcgccgccg  agccgaagg  gctggcgcc  ccgcggccg  360
tgcctccgc  gagcccaaa  tcatgaaag  caccgtgaa  accccgaag  aaaaggagg  420
attcgccgt  cccgagaat  gctccgtcc  gcagtttaa  gaagaaatc  ctaaacgtt  480
taaatcaca  actgaccaa  ttgtgttga  atttgctgg  aaaattttg  aagatcaag  540
taccttgag  cagcatgga  ttcatgatg  acttactgt  caccttgtc  ttaaaacac  600
aaacaggcc  caggatcat  cagctcagc  aacaaatac  gctggaagc  atgttacta  660
atcatcaac  cctaatagt  actctacat  tggttctgc  actagcaac  cttttggtt  720
aggtggcct  gggggactt  caggtctga  tagcttggg  ttgaatact  ccaacttct  780
tgaactaca  agtcagatg  agcgacaac  tttgtctaa  cctgaaatg  tggtccaga  840
catggaaaa  ccctttgtt  agagcatgc  ctcaaatcc  gacctgatg  gacagttaa  900
tatggccaa  ccacaaatg  agcagttga  acagagaaa  ccagaaatt  gtcatatgt  960
gaataatcc  gatataatg  gacaaacgt  ggaacttgc  aggaatcca  caatgatgc  1020
ggagatgat  aggaaccag  accgagctt  gagcaacct  gaaagcatc  cagggggat  1080
taatgcttt  aggcgcatg  acacagata  tcaggaacc  atgctgagt  ctgcacaag  1140
gcagtttgg  ggtaatcca  ttgcttcct  ggtgagcaa  acatcctct  gtgaaggta  1200
tcaaccttc  cgtacagaa  atagagatc  actacccaa  ccatgggct  cacagactt  1260
ccagagttc  tcagcttcc  gcggcactg  cagcactgt  ggtggcact  ctggtagta  1320
tgccagtgg  acttctggg  agagtacta  tgcgccaaa  ttggtgcct  gagtaggag  1380
tagtatgtt  aacacacca  gaatgcaga  cttgttgca  caaataact  aaaacccac  1440
actgatgca  aacatgttg  ctgccccct  catgagaag  atgatgcag  cactaagcc  1500
gaatcctga  cttgctgca  agatgcaga  tcctgatac  ctatcagca  tgtcaaacc  1560
tagagcaat  caggccttg  tacagattc  gcagggttt  cagacatta  caacggaag  1620
cccgggcct  atcccaggg  ttactcctg  cttgggggc  ttaggaagc  ctggaggct  1680
ttcgggaac  aatggatct  acgccacac  tagtgaaaa  acaagtccc  cagcaggaa  1740
cactgaacc  ggacatcag  agtttattc  gcagatgct  caggctctt  ctggagtaa  1800
tcctcagct  cagaatcca  aagtcagat  tcagcaaca  ctggaacaa  tcagtgcaa  1860
gggattttt  aaccgtgaa  caaacttgc  agctctaat  gcaacagga  gtgatatca  1920
tgcagctat  gaaaggtta  tgggctccc  gccatcata  cagcatttc  gtatcttga  1980
aaaatgtaa  ttatttttg  taacggctc  taaacttta  aatacctgc  ttatttcat  2040
ttgactctt  gaattctgt  ctgttataa  caaacccaa  atgatgcat  ttaaggtgg  2100
gtacagtaa  atgtgtggg  ttttctgta  ttttctttt  tggaacagt  ggaattaag  2160
ctactgcat  catcacttc  gcatttatt  taatttttt  aaaacatca  cttttatag  2220
tgggtgacc  gattttgtc  tgcatctgt  cagtttatt  gctttttaa  cattagcct  2280
tggtagtaa  ttatgtaga  taaaagcat  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2340
aaaaaaaaa  aaaa  2354



<210> 5271
<211> 589
<212> PRT
<213> Homo sapiens
<308> NP_038466
<400> 5271

Met Ala Glu Ser Gly Glu Ser Gly Gly Pro Pro Gly Ser Gln Asp Ser 
  1               5                  10                  15
Ala Ala Gly Ala Glu Gly Ala Gly Ala Pro Ala Ala Ala Ala Ser Ala 
             20                  25                  30
Glu Pro Lys Ile Met Lys Val Thr Val Lys Thr Pro Lys Glu Lys Glu 
         35                  40                  45
Glu Phe Ala Val Pro Glu Asn Ser Ser Val Gln Gln Phe Lys Glu Glu 
     50                  55                  60
Ile Ser Lys Arg Phe Lys Ser His Thr Asp Gln Leu Val Leu Ile Phe 
 65                  70                  75                  80
Ala Gly Lys Ile Leu Lys Asp Gln Asp Thr Leu Ser Gln His Gly Ile 
                 85                  90                  95
His Asp Gly Leu Thr Val His Leu Val Ile Lys Thr Gln Asn Arg Pro 
             100                105                110
Gln Asp His Ser Ala Gln Gln Thr Asn Thr Ala Gly Ser Asn Val Thr 
         115                120                125
Thr Ser Ser Thr Pro Asn Ser Asn Ser Thr Ser Gly Ser Ala Thr Ser 
     130                135                140
Asn Pro Phe Gly Leu Gly Gly Leu Gly Gly Leu Ala Gly Leu Ser Ser 
 145                150                155                160
Leu Gly Leu Asn Thr Thr Asn Phe Ser Glu Leu Gln Ser Gln Met Gln 
                 165                170                175
Arg Gln Leu Leu Ser Asn Pro Glu Met Met Val Gln Ile Met Glu Asn 
             180                185                190
Pro Phe Val Gln Ser Met Leu Ser Asn Pro Asp Leu Met Arg Gln Leu 
         195                200                205
Ile Met Ala Asn Pro Gln Met Gln Gln Leu Ile Gln Arg Asn Pro Glu 
     210                215                220
Ile Ser His Met Leu Asn Asn Pro Asp Ile Met Arg Gln Thr Leu Glu 
 225                230                235                240
Leu Ala Arg Asn Pro Ala Met Met Gln Glu Met Met Arg Asn Gln Asp 
                 245                250                255
Arg Ala Leu Ser Asn Leu Glu Ser Ile Pro Gly Gly Tyr Asn Ala Leu 
             260                265                270
Arg Arg Met Tyr Thr Asp Ile Gln Glu Pro Met Leu Ser Ala Ala Gln 
         275                280                285
Glu Gln Phe Gly Gly Asn Pro Phe Ala Ser Leu Val Ser Asn Thr Ser 
     290                295                300
Ser Gly Glu Gly Ser Gln Pro Ser Arg Thr Glu Asn Arg Asp Pro Leu 
 305                310                315                320
Pro Asn Pro Trp Ala Pro Gln Thr Ser Gln Ser Ser Ser Ala Ser Ser 
                 325                330                335
Gly Thr Ala Ser Thr Val Gly Gly Thr Thr Gly Ser Thr Ala Ser Gly 
             340                345                350
Thr Ser Gly Gln Ser Thr Thr Ala Pro Asn Leu Val Pro Gly Val Gly 
         355                360                365
Ala Ser Met Phe Asn Thr Pro Gly Met Gln Ser Leu Leu Gln Gln Ile 
     370                375                380
Thr Glu Asn Pro Gln Leu Met Gln Asn Met Leu Ser Ala Pro Tyr Met 
 385                390                395                400
Arg Ser Met Met Gln Ser Leu Ser Gln Asn Pro Asp Leu Ala Ala Gln 
                 405                410                415
Met Met Leu Asn Asn Pro Leu Phe Ala Gly Asn Pro Gln Leu Gln Glu 
             420                425                430
Gln Met Arg Gln Gln Leu Pro Thr Phe Leu Gln Gln Met Gln Asn Pro 
         435                440                445
Asp Thr Leu Ser Ala Met Ser Asn Pro Arg Ala Met Gln Ala Leu Leu 
     450                455                460
Gln Ile Gln Gln Gly Leu Gln Thr Leu Ala Thr Glu Ala Pro Gly Leu 
 465                470                475                480
Ile Pro Gly Phe Thr Pro Gly Leu Gly Ala Leu Gly Ser Thr Gly Gly 
                 485                490                495
Ser Ser Gly Thr Asn Gly Ser Asn Ala Thr Pro Ser Glu Asn Thr Ser 
             500                505                510
Pro Thr Ala Gly Thr Thr Glu Pro Gly His Gln Gln Phe Ile Gln Gln 
         515                520                525
Met Leu Gln Ala Leu Ala Gly Val Asn Pro Gln Leu Gln Asn Pro Glu 
     530                535                540
Val Arg Phe Gln Gln Gln Leu Glu Gln Leu Ser Ala Met Gly Phe Leu 
 545                550                555                560
Asn Arg Glu Ala Asn Leu Gln Ala Leu Ile Ala Thr Gly Gly Asp Ile 
                 565                570                575
Asn Ala Ala Ile Glu Arg Leu Leu Gly Ser Gln Pro Ser 
             580                585



<210> 5272
<211> 462
<212> DNA
<213> Rattus norvegicus
<308> AA875207
<400> 5272

ttttttttt  tttttttca  ttttaactc  ttatttgaa  caattccag  gacaagtta  60
ttgtgacaa  agtttctca  tacaacaca  gggtaggca  ggctcactg  aggaacagg  120
caggcacct  agtacaata  atacatttt  acagtggct  aactgatga  agttataaa  180
acaccaaaa  gaaggctag  gaacagcaa  gccaacagg  aaagaactg  gtgctccct  240
tgccagaca  taacttttc  gggcccaca  aggtaagat  gggaagaga  gacgtaggc  300
gtaggacag  accctggcc  acagctcct  acctatctt  tgaccacaa  ccccatcct  360
gatggccta  gagcctgaa  ttctcagga  ccacatgca  cttgtcaca  tggagttca  420
tgaggctgg  aaaggtgcc  ttgaggttg  ccaagtgtt  ca  462



<210> 5273
<211> 146
<212> PRT
<213> Rattus norvegicus
<308> P11517
<400> 5273

Val His Leu Thr Asp Ala Glu Lys Ala Thr Val Ser Gly Leu Trp Gly 
  1               5                  10                  15
Lys Val Asn Ala Asp Asn Val Gly Ala Glu Ala Leu Gly Arg Leu Leu 
             20                  25                  30
Val Val Tyr Pro Trp Thr Gln Arg Tyr Phe Ser Lys Phe Gly Asp Leu 
         35                  40                  45
Ser Ser Ala Ser Ala Ile Met Gly Asn Pro Gln Val Lys Ala His Gly 
     50                  55                  60
Lys Lys Val Ile Asn Ala Phe Asn Asp Gly Leu Lys His Leu Asp Asn 
 65                  70                  75                  80
Leu Lys Gly Thr Phe Ala His Leu Ser Glu Leu His Cys Asp Lys Leu 
                 85                  90                  95
His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Met Ile Val Ile 
             100                105                110
Val Leu Gly His His Leu Gly Lys Glu Phe Thr Pro Cys Ala Gln Ala 
         115                120                125
Ala Phe Gln Lys Val Val Ala Gly Val Ala Ser Ala Leu Ala His Lys 
     130                135                140
Tyr His 
 145



<210> 5274
<211> 585
<212> DNA
<213> Homo sapiens
<308> BG311786
<400> 5274

ntgtgttga  tttcacaac  ccagtaaac  tacatcatg  tgcacctga  tgatgctga  60
aaggctgct  tctctggcc  gtggggaaa  gtgaacgcc  atgaagttg  tggtgaggc  120
ctgggcaga  tgctggttg  ctacccttg  acccagcgg  actttgata  ctttggaga  180
ctatcctct  cctctgcta  catgggtaa  gccaaagtg  aggcccatg  caagaaagt  240
ataactgcc  ttaacgatg  cctgaatca  ttggacagc  tcaagggca  ctttgccag  300
ctcagtgag  tccactgtg  caagctgca  gtggatcct  agaacttca  gctcctggg  360
aatatgatc  tgattgtgc  gggccacca  ctgggcaag  atttcaccc  cgctgcaca  420
gctgccttc  agaaggtgg  ggctggagt  gccgctgcc  tggctcaca  gtaccacta  480
acccccttt  ctgctcttg  ctgtgaaca  tggttaatt  ttnccaaga  agcatctgt  540
agttgttgg  aaaatgata  agacatttg  aaatctgtc  tctga  585



<210> 5275
<211> 146
<212> PRT
<213> Homo sapiens
<308> P02023
<400> 5275

Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly 
  1               5                  10                  15
Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu 
             20                  25                  30
Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp Leu 
         35                  40                  45
Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His Gly 
     50                  55                  60
Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn 
 65                  70                  75                  80
Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu 
                 85                  90                  95
His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val Cys 
             100                105                110
Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln Ala 
         115                120                125
Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys 
     130                135                140
Tyr His 
 145



<210> 5276
<211> 422
<212> DNA
<213> Rattus norvegicus
<308> AA875217
<400> 5276

ttttttttt  tttttttca  tagaaaata  agtgtttat  aagaaacta  acactgaac  60
ctcctataa  tccctgtgg  aacacaatg  cccattgtc  tagcacaaa  tgaagaaat  120
ccagaataa  agatgctgt  atggatgga  cccgagagg  tggaaatga  gtcatgatt  180
acaacaatt  aaaacatca  cctcaagct  actccttaa  gccacactc  ggagtagat  240
tgaacccga  ggatcatct  ggtgatgag  tcactgaga  gacaacatg  agaccccat  300
cttccaagc  ggaaagtga  actggaaca  ggctggact  caggctttc  cgtgatggt  360
gggtcaaga  aatggctan  gtgtttaaa  ggtanctcc  ggtgcttgg  tttggattt  420
ct  422



<210> 5277
<211> 402
<212> DNA
<213> Homo sapiens
<308> BF512741
<400> 5277

ttttttttt  tttttttca  tagaaaata  agtgtttat  aagaaacta  acactgaac  60
ctcctataa  tctctgtgg  aacacaacg  cccattgtc  tagcacaag  tgaggaaaa  120
ggcagaata  aagatgctg  gatggatgg  gcctgggag  ctggaaatg  ggtaatgat  180
tacaataat  aaaaaacat  atcctcaag  ttactcctt  aagccacac  tgggaggag  240
ccctggacc  aaagcatca  cagggcaca  tggggaaca  cctgacatg  agcaatggg  300
agcaggatg  ggagagctg  agggggcga  ataaacaca  acctggagc  ctggagaga  360
cctgaactc  caggtgata  tctggaggc  gccccagat  ct  402



<210> 5278
<211> 438
<212> DNA
<213> Rattus norvegicus
<308> AA875225
<400> 5278

ttttttttt  tttctttct  cattttatt  tttcaaatc  tgtgaacaa  tccataaaa  60
atgtgaaaa  agcaaggaa  tgttcaacg  tggaggtcc  gggcctggg  cgaaggcgt  120
aggggcctg  ccctcagca  gcagcggcg  ttcctagat  agcgctaag  agctacatt  180
aggttaatg  agcctgggc  caaggcttc  gggcagggc  ctcagtgac  ttggcagtt  240
tctggaaca  cccttggga  ccaattccg  ggagggcag  gcatggggc  gcccaaaga  300
ggatgggtg  aaacaggca  acacactca  ggcacggaa  cactggaaa  gggctgggg  360
cggcgggag  gatgctggt  aagacctga  agttttaaa  aggtttctc  aaaaagttt  420
ctagatttg  aattttcc  438



<210> 5279
<211> 354
<212> PRT
<213> Rattus norvegicus
<308> P04897
<400> 5279

Gly Cys Thr Val Ser Ala Glu Asp Lys Ala Ala Ala Glu Arg Ser Lys 
  1               5                  10                  15
Met Ile Asp Lys Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg Glu 
             20                  25                  30
Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile 
         35                  40                  45
Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Glu Glu 
     50                  55                  60
Cys Arg Gln Tyr Arg Ala Val Val Tyr Ser Asn Thr Ile Gln Ser Ile 
 65                  70                  75                  80
Met Ala Ile Val Lys Ala Met Gly Asn Leu Gln Ile Asp Phe Ala Asp 
                 85                  90                  95
Pro Gln Arg Ala Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys Ala 
             100                105                110
Ala Glu Glu Gln Gly Met Leu Pro Glu Asp Leu Ser Gly Val Ile Arg 
         115                120                125
Arg Leu Trp Ala Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser Arg 
     130                135                140
Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Glu 
 145                150                155                160
Arg Ile Ala Gln Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg 
                 165                170                175
Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys 
             180                185                190
Asp Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg 
         195                200                205
Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys 
     210                215                220
Val Ala Leu Ser Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met 
 225                230                235                240
Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn 
                 245                250                255
Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp 
             260                265                270
Leu Phe Glu Glu Lys Ile Thr Gln Ser Pro Leu Thr Ile Cys Phe Pro 
         275                280                285
Glu Tyr Thr Gly Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile Gln 
     290                295                300
Ser Lys Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr 
 305                310                315                320
Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe 
                 325                330                335
Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly 
             340                345                350
Leu Phe 
         355



<210> 5280
<211> 2167
<212> DNA
<213> Homo sapiens
<308> AK055574
<400> 5280

agtcgctcg  aactgccga  ccgagtgct  cccgcagag  gctggtggt  ggagcggag  60
gggtcgggc  gggccgagc  gggccgtgg  ccgtgtggg  gccgggcgg  ggccgggcc  120
gcggacggc  ggatgggct  caccgtgag  gccgaggac  aggcggcgg  cgagcgctc  180
aagatgatc  acaagaacc  gcgggagga  ggagagaag  cggcgcggg  ggtgaagtt  240
ctgctgttg  gatcatcca  gaggatggc  actccgagg  ggaatgccg  cagtaccgg  300
cggttgtct  cagcaacac  atccagtcc  tcatggcca  tgtcaaagc  atgggcaac  360
tgcagatcg  ctttgccga  ccctccaga  cggacgacg  caggcagct  tttgcactg  420
cctgcaccg  cgaggagca  ggcgtgctc  ctgatgacc  gtccggcgt  atccggagg  480
tctgggctg  ccatggtgt  caggcctgc  ttggccgct  aagggaata  cagctcaac  540
actcagctg  ctactacct  aacgacctg  agcgtattg  acagagtga  tacatcccc  600
cacagcaag  tgtgctacg  acccgcgta  agaccacgg  gatcgtgga  acacacttc  660
ccttcaagg  cctacactt  aagatgttt  atgtgggtg  tcagcggtc  gagcggaag  720
agtggatcc  ctgctttga  ggcgtcaca  ccatcatct  ctgcgtagc  ttgagcgcc  780
atgacttgg  gctagctga  aacgaggag  tgaaccgca  gcatgagag  atgaagcta  840
tcgatagca  ctgcaacaa  aagtggttc  cagacacgt  catcatcct  ttcctcaac  900
agaaggacc  gtttgagga  aagatcaca  acagtcccc  gaccatctg  ttccctgag  960
acacagggg  caacaaata  gatgaggca  ccagctaca  ccagagtaa  tttgaggac  1020
tgaataagc  caaagacac  aaggagatc  acacgcact  cacgtgcgc  accgacacc  1080
agaacgtgc  gttcgtgtt  gacgccgtc  ccgatgtca  catcaagaa  aacctgaag  1140
actgcggcc  cttctgagg  gcagcgggg  ctggcggga  gggccaccg  cgactttgt  1200
ccccccaac  cctgaggaa  atgggggca  gaagatcac  ctccccgcc  gttcccccg  1260
cgcttttct  ctctttcct  tctttgttc  cagctcccc  tgtcccctc  gctccagac  1320
taggggagg  gttgccaca  gcctccctg  ttgaagcct  cccttgtct  agatgctgg  1380
aatggccat  gtaccccct  ctgggcatc  gttctggtt  ttaaccatt  tcttgttct  1440
tgatgaggg  aggggggca  atgctgagt  tcccaaggc  gcgtctgga  gggcccctg  1500
ttctccagc  tggaccccc  gctttgccc  acaccagcc  ctgccccag  ccaagtcca  1560
atgtttaca  ggagcctcc  gcccagtcc  ccaacccca  ccgctcgga  gccccaaag  1620
aaaaagcac  agaagcgtg  gacgccacc  ttcctggaa  ccacagtcc  cctgctcat  1680
ctcgtagct  tttaaaaaa  gaaagtaaa  gaaaaaaaa  aaactgcaa  tctagaaaa  1740
tttttagag  aaaactatt  aaaactgtc  gatcctgac  agcaagccc  cccccagcc  1800
cccttccaa  tgactccgt  ccttgagtg  gtctgcgtg  ttacacccg  ccctctgct  1860
gccgccccc  tgcgagcgg  acccctgcc  tgccctcca  agaattggg  tccaagggc  1920
gttccagac  actgccaac  tcactgagg  ccctgcccc  gcggccctg  ccccaggct  1980
tattaacct  aaatgtagc  ccctagcgc  aacctagga  ccgccgctg  ctgctgggg  2040
gccacgccc  tcatgccct  gtcccaggc  cggggcctt  agcgttgaa  acttccttg  2100
ttttttcac  tgttttatg  aattgttca  ctggtttga  ataataaaa  gtagaaaga  2160
aaaaaat  2167



<210> 5281
<211> 354
<212> PRT
<213> Homo sapiens
<308> P04899
<400> 5281

Gly Cys Thr Val Ser Ala Glu Asp Lys Ala Ala Ala Glu Arg Ser Lys 
  1               5                  10                  15
Met Ile Asp Lys Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg Glu 
             20                  25                  30
Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile 
         35                  40                  45
Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Glu Glu 
     50                  55                  60
Cys Arg Gln Tyr Arg Ala Val Val Tyr Ser Asn Thr Ile Gln Ser Ile 
 65                  70                  75                  80
Met Ala Ile Val Lys Ala Met Gly Asn Leu Gln Ile Asp Phe Ala Asp 
                 85                  90                  95
Pro Ser Arg Ala Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys Thr 
             100                105                110
Ala Glu Glu Gln Gly Val Leu Pro Asp Asp Leu Ser Gly Val Ile Arg 
         115                120                125
Arg Leu Trp Ala Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser Arg 
     130                135                140
Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Glu 
 145                150                155                160
Arg Ile Ala Gln Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg 
                 165                170                175
Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys 
             180                185                190
Asp Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg 
         195                200                205
Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys 
     210                215                220
Val Ala Leu Ser Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met 
 225                230                235                240
Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn 
                 245                250                255
Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp 
             260                265                270
Leu Phe Glu Glu Lys Ile Thr His Ser Pro Leu Thr Ile Cys Phe Pro 
         275                280                285
Glu Tyr Thr Gly Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile Gln 
     290                295                300
Ser Lys Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr 
 305                310                315                320
Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe 
                 325                330                335
Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly 
             340                345                350
Leu Phe 
         355



<210> 5282
<211> 438
<212> DNA
<213> Rattus norvegicus
<308> AA875225
<400> 5282

ttttttttt  tttctttct  cattttatt  tttcaaatc  tgtgaacaa  tccataaaa  60
atgtgaaaa  agcaaggaa  tgttcaacg  tggaggtcc  gggcctggg  cgaaggcgt  120
aggggcctg  ccctcagca  gcagcggcg  ttcctagat  agcgctaag  agctacatt  180
aggttaatg  agcctgggc  caaggcttc  gggcagggc  ctcagtgac  ttggcagtt  240
tctggaaca  cccttggga  ccaattccg  ggagggcag  gcatggggc  gcccaaaga  300
ggatgggtg  aaacaggca  acacactca  ggcacggaa  cactggaaa  gggctgggg  360
cggcgggag  gatgctggt  aagacctga  agttttaaa  aggtttctc  aaaaagttt  420
ctagatttg  aattttcc  438



<210> 5283
<211> 354
<212> PRT
<213> Rattus norvegicus
<308> P04897
<400> 5283

Gly Cys Thr Val Ser Ala Glu Asp Lys Ala Ala Ala Glu Arg Ser Lys 
  1               5                  10                  15
Met Ile Asp Lys Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg Glu 
             20                  25                  30
Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile 
         35                  40                  45
Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Glu Glu 
     50                  55                  60
Cys Arg Gln Tyr Arg Ala Val Val Tyr Ser Asn Thr Ile Gln Ser Ile 
 65                  70                  75                  80
Met Ala Ile Val Lys Ala Met Gly Asn Leu Gln Ile Asp Phe Ala Asp 
                 85                  90                  95
Pro Gln Arg Ala Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys Ala 
             100                105                110
Ala Glu Glu Gln Gly Met Leu Pro Glu Asp Leu Ser Gly Val Ile Arg 
         115                120                125
Arg Leu Trp Ala Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser Arg 
     130                135                140
Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Glu 
 145                150                155                160
Arg Ile Ala Gln Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg 
                 165                170                175
Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys 
             180                185                190
Asp Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg 
         195                200                205
Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys 
     210                215                220
Val Ala Leu Ser Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met 
 225                230                235                240
Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn 
                 245                250                255
Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp 
             260                265                270
Leu Phe Glu Glu Lys Ile Thr Gln Ser Pro Leu Thr Ile Cys Phe Pro 
         275                280                285
Glu Tyr Thr Gly Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile Gln 
     290                295                300
Ser Lys Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr 
 305                310                315                320
Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe 
                 325                330                335
Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly 
             340                345                350
Leu Phe 
         355



<210> 5284
<211> 2167
<212> DNA
<213> Homo sapiens
<308> AK055574
<400> 5284

agtcgctcg  aactgccga  ccgagtgct  cccgcagag  gctggtggt  ggagcggag  60
gggtcgggc  gggccgagc  gggccgtgg  ccgtgtggg  gccgggcgg  ggccgggcc  120
gcggacggc  ggatgggct  caccgtgag  gccgaggac  aggcggcgg  cgagcgctc  180
aagatgatc  acaagaacc  gcgggagga  ggagagaag  cggcgcggg  ggtgaagtt  240
ctgctgttg  gatcatcca  gaggatggc  actccgagg  ggaatgccg  cagtaccgg  300
cggttgtct  cagcaacac  atccagtcc  tcatggcca  tgtcaaagc  atgggcaac  360
tgcagatcg  ctttgccga  ccctccaga  cggacgacg  caggcagct  tttgcactg  420
cctgcaccg  cgaggagca  ggcgtgctc  ctgatgacc  gtccggcgt  atccggagg  480
tctgggctg  ccatggtgt  caggcctgc  ttggccgct  aagggaata  cagctcaac  540
actcagctg  ctactacct  aacgacctg  agcgtattg  acagagtga  tacatcccc  600
cacagcaag  tgtgctacg  acccgcgta  agaccacgg  gatcgtgga  acacacttc  660
ccttcaagg  cctacactt  aagatgttt  atgtgggtg  tcagcggtc  gagcggaag  720
agtggatcc  ctgctttga  ggcgtcaca  ccatcatct  ctgcgtagc  ttgagcgcc  780
atgacttgg  gctagctga  aacgaggag  tgaaccgca  gcatgagag  atgaagcta  840
tcgatagca  ctgcaacaa  aagtggttc  cagacacgt  catcatcct  ttcctcaac  900
agaaggacc  gtttgagga  aagatcaca  acagtcccc  gaccatctg  ttccctgag  960
acacagggg  caacaaata  gatgaggca  ccagctaca  ccagagtaa  tttgaggac  1020
tgaataagc  caaagacac  aaggagatc  acacgcact  cacgtgcgc  accgacacc  1080
agaacgtgc  gttcgtgtt  gacgccgtc  ccgatgtca  catcaagaa  aacctgaag  1140
actgcggcc  cttctgagg  gcagcgggg  ctggcggga  gggccaccg  cgactttgt  1200
ccccccaac  cctgaggaa  atgggggca  gaagatcac  ctccccgcc  gttcccccg  1260
cgcttttct  ctctttcct  tctttgttc  cagctcccc  tgtcccctc  gctccagac  1320
taggggagg  gttgccaca  gcctccctg  ttgaagcct  cccttgtct  agatgctgg  1380
aatggccat  gtaccccct  ctgggcatc  gttctggtt  ttaaccatt  tcttgttct  1440
tgatgaggg  aggggggca  atgctgagt  tcccaaggc  gcgtctgga  gggcccctg  1500
ttctccagc  tggaccccc  gctttgccc  acaccagcc  ctgccccag  ccaagtcca  1560
atgtttaca  ggagcctcc  gcccagtcc  ccaacccca  ccgctcgga  gccccaaag  1620
aaaaagcac  agaagcgtg  gacgccacc  ttcctggaa  ccacagtcc  cctgctcat  1680
ctcgtagct  tttaaaaaa  gaaagtaaa  gaaaaaaaa  aaactgcaa  tctagaaaa  1740
tttttagag  aaaactatt  aaaactgtc  gatcctgac  agcaagccc  cccccagcc  1800
cccttccaa  tgactccgt  ccttgagtg  gtctgcgtg  ttacacccg  ccctctgct  1860
gccgccccc  tgcgagcgg  acccctgcc  tgccctcca  agaattggg  tccaagggc  1920
gttccagac  actgccaac  tcactgagg  ccctgcccc  gcggccctg  ccccaggct  1980
tattaacct  aaatgtagc  ccctagcgc  aacctagga  ccgccgctg  ctgctgggg  2040
gccacgccc  tcatgccct  gtcccaggc  cggggcctt  agcgttgaa  acttccttg  2100
ttttttcac  tgttttatg  aattgttca  ctggtttga  ataataaaa  gtagaaaga  2160
aaaaaat  2167



<210> 5285
<211> 354
<212> PRT
<213> Homo sapiens
<308> P04899
<400> 5285

Gly Cys Thr Val Ser Ala Glu Asp Lys Ala Ala Ala Glu Arg Ser Lys 
  1               5                  10                  15
Met Ile Asp Lys Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg Glu 
             20                  25                  30
Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile 
         35                  40                  45
Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Glu Glu 
     50                  55                  60
Cys Arg Gln Tyr Arg Ala Val Val Tyr Ser Asn Thr Ile Gln Ser Ile 
 65                  70                  75                  80
Met Ala Ile Val Lys Ala Met Gly Asn Leu Gln Ile Asp Phe Ala Asp 
                 85                  90                  95
Pro Ser Arg Ala Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys Thr 
             100                105                110
Ala Glu Glu Gln Gly Val Leu Pro Asp Asp Leu Ser Gly Val Ile Arg 
         115                120                125
Arg Leu Trp Ala Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser Arg 
     130                135                140
Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Glu 
 145                150                155                160
Arg Ile Ala Gln Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg 
                 165                170                175
Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys 
             180                185                190
Asp Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg 
         195                200                205
Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys 
     210                215                220
Val Ala Leu Ser Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met 
 225                230                235                240
Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn 
                 245                250                255
Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp 
             260                265                270
Leu Phe Glu Glu Lys Ile Thr His Ser Pro Leu Thr Ile Cys Phe Pro 
         275                280                285
Glu Tyr Thr Gly Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile Gln 
     290                295                300
Ser Lys Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr 
 305                310                315                320
Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe 
                 325                330                335
Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly 
             340                345                350
Leu Phe 
         355



<210> 5287
<211> 181
<212> PRT
<213> Rattus norvegicus
<308> P41276
<400> 5287

Met Gly Gly Phe Phe Ser Ser Ile Phe Ser Ser Leu Phe Gly Thr Arg 
  1               5                  10                  15
Glu Met Arg Ile Leu Ile Leu Gly Leu Asp Gly Ala Gly Lys Thr Thr 
             20                  25                  30
Ile Leu Tyr Arg Leu Gln Val Gly Glu Val Val Thr Thr Ile Pro Thr 
         35                  40                  45
Ile Gly Phe Asn Val Glu Thr Val Thr Tyr Lys Asn Leu Lys Phe Gln 
     50                  55                  60
Val Trp Asp Leu Gly Gly Gln Thr Ser Ile Arg Pro Tyr Trp Arg Cys 
 65                  70                  75                  80
Tyr Tyr Ser Asn Thr Asp Ala Val Ile Tyr Val Val Asp Ser Cys Asp 
                 85                  90                  95
Arg Asp Arg Ile Gly Ile Ser Lys Ser Glu Leu Val Ala Met Leu Glu 
             100                105                110
Glu Glu Glu Leu Arg Lys Ala Ile Leu Val Val Phe Ala Asn Lys Gln 
         115                120                125
Asp Met Glu Gln Ala Met Thr Pro Ser Glu Met Ala Asn Ala Leu Gly 
     130                135                140
Leu Pro Ala Leu Lys Asp Arg Lys Trp Gln Ile Phe Lys Thr Ser Ala 
 145                150                155                160
Thr Lys Gly Thr Gly Leu Asp Glu Ala Met Glu Trp Leu Val Glu Thr 
                 165                170                175
Leu Lys Ser Arg Gln 
             180



<210> 5288
<211> 1008
<212> DNA
<213> Homo sapiens
<308> L28997
<400> 5288

aattcggta  cccgtagcg  ccggcgctc  gctggaatt  gggggaagt  gctggctga  600
tgggcttgc  aggaaaccg  ctcggagct  cagcgaagg  caaggaatc  ctgaagatc  660
gcgagggag  acagggggt  catcatggg  ggctttttc  caagtatat  ttccagtct  720
tttggaact  gggaaatga  aattttaat  ttgggatta  atggagcag  aaaaaccac  780
attttgtac  gattacaag  gggagaagt  gttactact  tacctacca  tggatttaa  840
gtagagacg  tgacgtaca  aaaccttaa  ttccaagtc  gggatttag  aggacagac  900
agtatcagg  catactgga  atgttacta  tcaaacaca  atgcagtca  ttatgtagt  960
gacagttgt  accgagacc  aattggcat  tccaaatca  agttagtt  1008



<210> 5289
<211> 181
<212> PRT
<213> Homo sapiens
<308> P40616
<400> 5289

Met Gly Gly Phe Phe Ser Ser Ile Phe Ser Ser Leu Phe Gly Thr Arg 
  1               5                  10                  15
Glu Met Arg Ile Leu Ile Leu Gly Leu Asp Gly Ala Gly Lys Thr Thr 
             20                  25                  30
Ile Leu Tyr Arg Leu Gln Val Gly Glu Val Val Thr Thr Ile Pro Thr 
         35                  40                  45
Ile Gly Phe Asn Val Glu Thr Val Thr Tyr Lys Asn Leu Lys Phe Gln 
     50                  55                  60
Val Trp Asp Leu Gly Gly Gln Thr Ser Ile Arg Pro Tyr Trp Arg Cys 
 65                  70                  75                  80
Tyr Tyr Ser Asn Thr Asp Ala Val Ile Tyr Val Val Asp Ser Cys Asp 
                 85                  90                  95
Arg Asp Arg Ile Gly Ile Ser Lys Ser Glu Leu Val Ala Met Leu Glu 
             100                105                110
Glu Glu Glu Leu Arg Lys Ala Ile Leu Val Val Phe Ala Asn Lys Gln 
         115                120                125
Asp Met Glu Gln Ala Met Thr Ser Ser Glu Met Ala Asn Ser Leu Gly 
     130                135                140
Leu Pro Ala Leu Lys Asp Arg Lys Trp Gln Ile Phe Lys Thr Ser Ala 
 145                150                155                160
Thr Lys Gly Thr Gly Leu Asp Glu Ala Met Glu Trp Leu Val Glu Thr 
                 165                170                175
Leu Lys Ser Arg Gln 
             180



<210> 5290
<211> 469
<212> DNA
<213> Rattus norvegicus
<308> AA875263
<400> 5290

ttttttttt  tttttttac  ttggaactc  gtacttttt  tttacaaaa  acgaaaaca  60
aaaggagga  tctaaagct  atccactgg  gacacagga  tgatgtggc  atggtgggg  120
ctctggctc  ggggaggca  aggggtccc  gcctctcct  gcgtcccca  ggtgacccc  180
ccttgcctc  aaggctcaa  caatggtcc  gcagttggg  cactaccca  tctgggtac  240
agcgatttc  aggagcctg  gttcccagc  caagggagc  ggaatgaca  gggaaactg  300
ggccagaga  tgccctggt  tctgctacc  gcctcactg  ggtgtgatc  tggcagcct  360
agcccggat  agggcaatg  ggtcctggt  gatgaggaa  acaaatcgc  ggctggcga  420
ctccaccac  gagttgttg  taaggcgcc  cttggagcc  cacagcaca  469



<210> 5291
<211> 1866
<212> DNA
<213> Homo sapiens
<308> AF015308
<400> 5291

ggaatgaat  tcctctcag  ctttaagct  acctggtca  aatccttgg  tgagcctgt  60
ggaccgttc  tcctagccc  gtggtttgg  accagtggc  ttnggactg  aagaggatg  120
acaaagatt  tcaggggct  ctagattca  ccctgatgg  atcaggcac  gccagccgc  180
cagaggatg  ggagtcact  gcagggcag  agcgagcct  ctcccaggc  ttgggcacc  240
tccctaaac  gagaagctc  tccaggttc  tcaagagga  gaagttcga  gatgagctg  300
tggagagca  cctggcaaa  tcttctacc  gggcaaagg  ggccagtgg  gtggaacca  360
ggcgctgtt  ggggagtga  ccctcctcc  gtgagaaga  gaaggtatc  aaagccccc  420
gcactcctg  gccacccag  ccagcccca  cccctggac  caccaagcg  gtgaagaag  480
gtaaacagc  acttcaggt  accaaggat  tgggccgct  gaagcctgc  gatgacctc  540
tgctcataa  tgctgtgtt  cagaccaac  acctgacct  cgtccacct  ggcgtgaaa  600
tcagctgcc  cttcaccct  cgggaggtc  aggagcgtt  gtacgccct  ctctacgat  660
ctgtcatct  caagttggc  tgtcaggcc  tgaggcagc  gcacccaga  gctattgca  720
ccatccaga  caaggccct  tttagcaag  ctgaggagc  gctgctgag  aaagtggga  780
cgaccagcc  gcccacctt  gagaccttc  aggacctgc  gcacagaca  cctgatgcc  840
tctacctgg  ccgtaccgc  aaggccctg  aggcccact  gcagctcat  aagcagtat  900
acctgctgg  ggaccagac  gtgcagccg  tgcccaaag  ggaccaagt  ctgaacttc  960
ctgatgcag  ggacctgat  gatgacagt  agctcaagg  catgcgaga  gaggtcctg  1020
aacatgagc  gatggtggc  gaccggcgc  agaagcgag  gattcggca  ctggaacag  1080
aactgcata  gtggcaggt  ctagtggac  gcatcacag  catgagctc  ccggacttc  1140
acaaccaga  actggcagt  ctgcggggc  gcatggtgc  gtacctgat  cgctcgcgt  1200
agatcaccc  gggcagagc  accaaggat  accagattg  tgtggacct  tctctggag  1260
gtccggcct  gaagatatc  cggaaacaa  gtgtcatca  gctgaagaa  aacggtgat  1320
tcttcattg  caatgaggg  cgacggccc  tctacatcg  tggacggcc  gtgctctgt  1380
gctccaaat  gcgcctcag  aacaactct  tggtggaga  cgccagcct  cgattcgtc  1440
tccttatca  ccaggacct  attgccctc  tcagggctg  ggctgccaa  atcacacca  1500
agtgaggag  ggtggcagg  ctcgtgggc  ctctccggc  tgtttcccc  gccactcca  1560
cccccttga  ctgggaact  aggctcctg  aaaaacctg  gcagtggga  gctcagctg  1620
gggccattg  tttgagcct  tgagggagg  tagggctgg  ctttgtgaa  ccagcagag  1680
ctgagaacc  caggcttcc  tagatccag  gcccctccc  atcttcctc  ctctaaaaa  1740
aaccctacc  cccattgcc  ccttcactc  tgtgtctcc  gctgattag  ctcagactc  1800
tcttttatt  tttttcttt  gtaaataaa  agcacccag  ttccaaaaa  aaaaaaaaa  1860
aaaaaa  1866



<210> 5292
<211> 463
<212> PRT
<213> Homo sapiens
<308> AF015308
<400> 5292

Met Asp Lys Asp Ser Gln Gly Leu Leu Asp Ser Ser Leu Met Ala Ser 
  1               5                  10                  15
Gly Thr Ala Ser Arg Ser Glu Asp Glu Glu Ser Leu Ala Gly Gln Lys 
             20                  25                  30
Arg Ala Ser Ser Gln Ala Leu Gly Thr Ile Pro Lys Arg Arg Ser Ser 
         35                  40                  45
Ser Arg Phe Ile Lys Arg Lys Lys Phe Asp Asp Glu Leu Val Glu Ser 
     50                  55                  60
Ser Leu Ala Lys Ser Ser Thr Arg Ala Lys Gly Ala Ser Gly Val Glu 
 65                  70                  75                  80
Pro Gly Arg Cys Ser Gly Ser Glu Pro Ser Ser Ser Glu Lys Lys Lys 
                 85                  90                  95
Val Ser Lys Ala Pro Ser Thr Pro Val Pro Pro Ser Pro Ala Pro Ala 
             100                105                110
Pro Gly Leu Thr Lys Arg Val Lys Lys Ser Lys Gln Pro Leu Gln Val 
         115                120                125
Thr Lys Asp Leu Gly Arg Trp Lys Pro Ala Asp Asp Leu Leu Leu Ile 
     130                135                140
Asn Ala Val Leu Gln Thr Asn Asp Leu Thr Ser Val His Leu Gly Val 
 145                150                155                160
Lys Phe Ser Cys Arg Phe Thr Leu Arg Glu Val Gln Glu Arg Trp Tyr 
                 165                170                175
Ala Leu Leu Tyr Asp Pro Val Ile Ser Lys Leu Ala Cys Gln Ala Met 
             180                185                190
Arg Gln Leu His Pro Glu Ala Ile Ala Ala Ile Gln Ser Lys Ala Leu 
         195                200                205
Phe Ser Lys Ala Glu Glu Gln Leu Leu Ser Lys Val Gly Ser Thr Ser 
     210                215                220
Gln Pro Thr Leu Glu Thr Phe Gln Asp Leu Leu His Arg His Pro Asp 
 225                230                235                240
Ala Phe Tyr Leu Gly Arg Thr Ala Lys Ala Leu Gln Ala His Trp Gln 
                 245                250                255
Leu Met Lys Gln Tyr Tyr Leu Leu Glu Asp Gln Thr Val Gln Pro Leu 
             260                265                270
Pro Lys Gly Asp Gln Val Leu Asn Phe Ser Asp Ala Glu Asp Leu Ile 
         275                280                285
Asp Asp Ser Lys Leu Lys Asp Met Arg Asp Glu Val Leu Glu His Glu 
     290                295                300
Leu Met Val Ala Asp Arg Arg Gln Lys Arg Glu Ile Arg Gln Leu Glu 
 305                310                315                320
Gln Glu Leu His Lys Trp Gln Val Leu Val Asp Ser Ile Thr Gly Met 
                 325                330                335
Ser Ser Pro Asp Phe Asp Asn Gln Thr Leu Ala Val Leu Arg Gly Arg 
             340                345                350
Met Val Arg Tyr Leu Met Arg Ser Arg Glu Ile Thr Leu Gly Arg Ala 
         355                360                365
Thr Lys Asp Asn Gln Ile Asp Val Asp Leu Ser Leu Glu Gly Pro Ala 
     370                375                380
Trp Lys Ile Ser Arg Lys Gln Gly Val Ile Lys Leu Lys Asn Asn Gly 
 385                390                395                400
Asp Phe Phe Ile Ala Asn Glu Gly Arg Arg Pro Ile Tyr Ile Asp Gly 
                 405                410                415
Arg Pro Val Leu Cys Gly Ser Lys Trp Arg Leu Ser Asn Asn Ser Val 
             420                425                430
Val Glu Ile Ala Ser Leu Arg Phe Val Phe Leu Ile Asn Gln Asp Leu 
         435                440                445
Ile Ala Leu Ile Arg Ala Glu Ala Ala Lys Ile Thr Pro Gln Ter 
     450                455                460



<210> 5293
<211> 466
<212> DNA
<213> Rattus norvegicus
<308> AA875268
<400> 5293

ttttttttt  tttttttgg  tcagggcgg  tttattcac  gggattctg  gatcctcac  60
ttcggcttg  cagctctac  tgcggtacc  gatcttcag  ttctgttcg  gtttgatct  120
ccgctgcag  tgcaagatg  cgtagagca  cgcctcggc  gtgggcggg  agcctggca  180
atagatgtc  actggcaca  ttcggtcac  gccacgaac  accgagtag  agtagtggt  240
gtagccacc  ccattggca  agctcccca  ggacaccac  taccggggt  cgggcatct  300
gtcgtacac  ttgcggagt  ctggagcca  cttgttagt  agcgtgcca  ctacgatca  360
cacgtcagc  tggcgcggg  tggcacgga  caccacacc  aagcggtcc  tgtcatanc  420
cggggcggc  atgtgcatc  tctccacgg  acagcacgc  aagccg  466



<210> 5294
<211> 968
<212> DNA
<213> Homo sapiens
<308> BG675079
<400> 5294

ggctgcgct  tgcacgcgg  cacgcgggc  ccggctgcg  gaagcgaga  tgaggcaag  60
tccctgcag  ctgcccacc  acggccgag  ccctgctct  cggcatcct  cagctgcag  120
ggaagatca  gcgggagcg  aggctgcag  tctggtacc  caggtagcg  cgccgccgc  180
gccgccgga  cctgtcgcc  tcctgtccc  agtcctgct  gtgtcccgt  aggttgtca  240
taaacctgc  ctcgggctg  cgccaaaaa  aaaaaaaaa  aacaaaaaa  aaagaaaaa  300
aaaaaaaaa  acgaaacaa  aaaagaaag  gggggcgga  ccggcctac  gaacataat  360
cccagagag  ggccacaag  taatcacga  cacaccccc  agtttttgg  tggaagaaa  420
gggcgcccc  caatagaga  agcgcggat  atttatacc  caatgcgac  gaacgcgat  480
acccagcct  actttacaa  accaccagc  catgcggga  tgagcgaga  cacaacacg  540
gagtgctca  ctgcggcag  acaacccat  cctggagaa  aagaaacgc  ccaacttaa  600
cgacggcgg  gggggaggg  acacgacca  tattggggc  aggcaagca  acatcacct  660
ccgagcaag  tcagaatgt  atcaaccgg  ccctctgca  agaggggga  aatataata  720
ataccaaaa  tgtagttaa  ggaggagtg  ataataatt  gatgggtgg  tgatacaac  780
acaaacatg  aggtcagta  atatagtgc  gtcaagcag  ggaaggtga  agaaaaaaa  840
agttagttc  ggtcattag  accagcggg  gagaaatta  ctataataa  ggcgacaag  900
gaatttttt  ttattacat  cggcggggg  gggggtgtg  tccagtata  ataatagaa  960
atcgagaa  968



<210> 5295
<211> 527
<212> DNA
<213> Rattus norvegicus
<308> AA875269
<400> 5295

ttttttttt  tttttttgc  gtcagatcc  tttcatttt  ttatgaaca  acacaacct  60
agatgagta  aaatacttt  agagttggt  ttaatgaaa  ttattagat  acaaatagc  120
actgttgca  ataataaag  aaaaaaaaa  cccacccaa  gaaggaaaa  gagtcctgc  180
ggtttccat  gcaatgagt  tacattatc  aatgcatcc  ttcaacctc  gagaagaat  240
atgtagatt  acaatgtcg  ctgggacat  ggcacgtgt  aagtccatg  tggacggtt  300
ctataaaaa  gtgcaggac  taaatactc  tctgctgag  atccccaaa  gttttataa  360
gagcatttg  tcatgctcg  acctacccg  ggaggtagg  caggaatat  atcccatgt  420
tcacagaat  ctgagtcac  ttatattgt  aggcgacat  cccagtgct  cggtttgag  480
ctgtcccat  attcacggg  tggaaactt  atccccaat  caacagt  527



<210> 5296
<211> 358
<212> PRT
<213> Rattus norvegicus
<308> NP_114029
<400> 5296

Met Pro Ala His Ile Leu Gln Glu Ile Ser Gly Ser Tyr Ser Ala Thr 
  1               5                  10                  15
Thr Thr Ile Thr Ala Pro Pro Ser Gly Gly Gln Gln Asn Gly Gly Glu 
             20                  25                  30
Lys Phe Glu Lys Asn Pro His His Trp Gly Ala Asp Val Arg Pro Glu 
         35                  40                  45
Ile Lys Asp Asp Leu Tyr Asp Pro Ser Tyr Gln Asp Glu Glu Gly Pro 
     50                  55                  60
Pro Pro Lys Leu Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ala Leu 
 65                  70                  75                  80
Leu His Ile Gly Ala Leu Tyr Gly Ile Thr Leu Val Pro Ser Cys Lys 
                 85                  90                  95
Val Tyr Thr Cys Leu Phe Ala Tyr Leu Tyr Tyr Val Ile Ser Ala Leu 
             100                105                110
Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Thr Tyr Lys 
         115                120                125
Ala Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met Ala 
     130                135                140
Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His His 
 145                150                155                160
Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly Phe 
                 165                170                175
Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala Val 
             180                185                190
Lys Glu Lys Gly Gly Lys Leu Asp Met Ser Asp Leu Lys Ala Glu Lys 
         195                200                205
Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Leu Met 
     210                215                220
Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Cys Trp Gly Glu Thr 
 225                230                235                240
Phe Val Asn Ser Leu Cys Val Ser Thr Phe Leu Arg Tyr Ala Val Val 
                 245                250                255
Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Tyr Gly Tyr 
             260                265                270
Arg Pro Tyr Asp Lys Asn Ile Ser Ser Arg Glu Asn Ile Leu Val Ser 
         275                280                285
Met Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ala Phe Pro 
     290                295                300
Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr Thr 
 305                310                315                320
Phe Phe Ile Asp Cys Met Ala Leu Leu Gly Leu Ala Tyr Asp Arg Lys 
                 325                330                335
Arg Val Ser Lys Ala Ala Val Leu Ala Arg Ile Lys Arg Thr Gly Glu 
             340                345                350
Glu Ser Cys Lys Ser Gly 
         355



<210> 5297
<211> 5221
<212> DNA
<213> Homo sapiens
<308> AF097514
<400> 5297

ataaaaggg  gctgaggaa  taccggaca  ggtcacccg  tgccagctc  agcctttaa  60
ttcccggct  ggggacctc  acgcaccgc  gctagcgcc  acaaccagc  agcgtgcaa  120
gcgccgcgg  tcagcgcgt  ccggcgggc  tcgaaaccg  agtcctccg  cgaccccga  180
ctccgctcc  gagcctcag  cccctggaa  gtgatcccg  catccgaga  ccaagatgc  240
ggcccactt  ctgcaggac  atatctcta  ctcctatac  accaccacc  ccattacag  300
gcctccctc  agggtcctg  agaatggag  agataagtt  gagacgatg  ccctctact  360
ggaagacga  attcgccct  atataaaag  tgatatata  gaccccacc  acaaggata  420
ggaaggccc  agccccaag  ttgaatatg  ctggagaaa  atcatcctt  tgtctctgc  480
acacttggg  gccctgtat  ggatcactt  gattcctac  tgcaagttc  acacctggc  540
ttggggggt  ttctactat  ttgtcagtg  cctgggcat  acagcagga  ctcatcgtc  600
gtggagcca  cgctcttac  aagctcggc  gcccctacg  ctctttctg  tcattgcca  660
cacaatggc  ttccagaat  atgtctatg  atgggctcg  gaccaccgt  cccaccaca  720
gttttcaga  acacatgct  atcctcata  ttcccgacg  ggctttttc  tctctcacg  780
gggttggct  cttgtgcgc  aacacccag  tgtcaaaga  aaggggagt  cgctagact  840
gtctgacct  gaagctgag  aactggtga  gttccagag  aggtactac  aacctggct  900
gctgctgat  tgcttcatc  tgcccacgc  tgtgccctg  tatttctgg  gtgaaactt  960
tcaaaacag  gtgttcgtt  ccactttct  gcgatatgc  gtggtgctt  atgccacct  1020
gctggtgaa  agtgctgcc  acctcttcg  atatcgtcc  tatgacaag  acattagcc  1080
ccgggagaa  atcctggtt  cacttggag  tgtgggtga  ggcttccac  actaccacc  1140
ctcctttcc  tatgactac  ctgccagtg  gtaccgctg  cacatcaac  tcaccacat  1200
cttcattga  tgcatggcc  ccctcggtc  ggcctatga  cggaagaaa  tctccaagg  1260
cgccatctt  gccaggatt  aaagaaccg  agatggaaa  tacaagagt  gctgagttt  1320
gggtccctc  ggtttcctt  ttcaaaaac  agccaggca  aggttttaa  gtctgttta  1380
taactactg  ataatgcta  caggatgct  aagatgatg  tgttaaccc  ttccagtac  1440
gtattcttt  aaaattcaa  agtattgaa  gccaacaac  ctgccttta  gatgctaag  1500
tgatattat  tcttctctt  tcctctctc  cttctaggc  cattgtcct  cttttcact  1560
tattgctat  gccctcctt  cccttattg  ctcccaggc  agcagctgg  cagtctttg  1620
tcagtgtcc  gcttccaaa  cctagacaa  ctttctgta  cctaaaacg  atggtcttt  1680
ctccagata  ctctctttc  ttgagctgt  gtgagcttt  aagtaggtg  cttgagcta  1740
agataaaac  gaatcttct  ggtagtccc  tgttgatta  cttcagccc  ggcttttgc  1800
agatggaat  gaaaagcaa  ttcatttga  acaaagctt  taaagcagg  aaattgtcg  1860
gggagagag  tagcatgta  gaatgtaag  atgagggaa  cgaagcaag  ggaacctct  1920
gccatgatc  gacatacag  tgcctacct  atgaggact  caagcccca  cacatagca  1980
gcttccttt  tctcctggc  cggggtaaa  agtggctgc  gtgtttggc  atgctaatt  2040
aatgccgca  catatagtt  aggccgagg  taaagaaaa  acattttaa  tttgtagta  2100
aagtggtct  tgctgggga  gggttttct  ttctttttt  ctttaataa  aaggagatt  2160
cttagttca  atatcaaga  gtcttgaag  tgggtgttt  cagaattgg  aaaaacagc  2220
gctcatgga  ttttgagta  tccatgagc  gctcattac  gttctttcc  ctttctgct  2280
tgccatctt  aggatattg  ttcttcccc  catagtaat  agatggctg  ggcatttcc  2340
aacatccaa  aaaagggaa  gatttaagg  ggtgaagtc  ggtcaaaaa  aaaatatat  2400
tacatatat  cattgctta  aacgttaaa  tattagagt  tttcccttc  aaagaggga  2460
gtttggaaa  aactctgaa  gagaggagg  attagttgg  atgccaatt  cctctccac  2520
gctggacat  agatggaga  gctgaggga  aggatctat  ggcagcttc  aagagcgaa  2580
ttcacatag  aagggatct  agaacacgt  gccaggggc  tgagaaggt  actgagtga  2640
ttattggga  tcttaataa  ataaactag  tattaggtc  attcattaa  tagttccag  2700
ttctccttg  aatgagtaa  aactagaag  cttctctcc  cagtgttgt  ccccttcac  2760
cattttttt  tgaggagaa  ggggtctct  ttaacatct  gcctaaagt  tacaactgc  2820
tggggggca  ggttaggaa  ctcttcact  ccctgattc  tgattcctg  ctctaccct  2880
tctgtccct  ttctttgac  agatctttc  cttccctga  cgttttctt  tttccctgg  2940
caggcagcc  cctttgtgt  tattcagag  cagtgatga  ttgctgtcc  ggcagctcc  3000
tcctgcaca  agaatgctc  gggtcactg  accactgct  ctcttttga  agtagagct  3060
gctgccact  tcacgtggc  tccgcagtg  ctccaccta  acccctgtg  tcccctgcc  3120
cactgatgg  tcaagacaa  gctggcaaa  cctcccaga  acatctctg  cccagaaag  3180
ctctctctc  ctccctctc  catgaggca  agccaagcc  agcgctcat  ttgagccag  3240
gggccagcc  cagagcaaa  gagggttta  tttcagtcc  ctctctctg  gtcagaacc  3300
gagggcatg  tgaatgccc  ctgcttact  ggtgagggt  ccccgcctg  gtcagtgct  3360
tcagctggc  gtgcaatgc  tgtagaagt  ggaggaaac  gttctcact  ggaagaagc  3420
agggcaaga  cccaagtgc  tcacctcga  aggaggccc  gttccctgg  gtcagggtg  3480
actgcaaag  tttggctga  acctgggat  tgagatacc  caaaccctg  tgaacacag  3540
gtctgttca  caaactaac  agcattccc  acagcctag  gcagacaat  gtatagaag  3600
ctggaaaaa  acaaaaaca  aatttgaga  ccttggacc  ctcctgtcc  tgtagctca  3660
tcatcaaag  agaagtctg  ctttgctct  ttaagattg  aaatgtaca  taccaaaca  3720
tcagtccac  gttgagccc  agtgctgga  gggaggaag  cctttcttc  gtgttaatt  3780
cgtagaggc  acaggggtt  gcctggact  aaggcatcc  tgtcttttg  gctattcac  3840
tcagtagaa  aggatctaa  ggaagatca  tgtagttta  ttctgttga  ctgtgcacc  3900
accccttgg  aatgtctgc  ggtatttct  attccacag  tcatcagat  cctgcttga  3960
aatatataa  caataaaaa  aactttcac  tcttcctat  gtaatcgtg  gccatggat  4020
tgatctgta  catgaccct  cataaggct  gatggcacc  caggctgag  gccccaatg  4080
atgtgtggc  gtgggtgtg  gtgggagtg  gtctgctga  taaggaaca  gattttcaa  4140
attctaaag  tcaattcaa  tgacacatt  atgataaac  cagatctga  caagagtcc  4200
gatttctaa  agtccctgc  ttggggggt  tgctgacaa  ttagctcag  tgccttaca  4260
cttttctaa  cacagtgtt  catatgagc  tgccctcac  ccctctgca  aatcccttt  4320
cacctgaga  cctactgaa  tggctggta  aaaaagggg  ctgagtgga  gattatcag  4380
atcacgatt  gcaggattc  cttctgggc  tcattctgg  aacttttgt  agggctgct  4440
ttcttaagt  cccacattt  atggagggt  gaaataatt  gaatgtatt  gatttataa  4500
ttttttttt  tttttgggt  aaaagatgg  tgtagcatt  aaaatggaa  attttctcc  4560
tggtttgct  gtatcttgg  tgtattctc  gtaagtgta  ctcaaatag  tcatcatga  4620
aggttaaaa  agcgaggtg  ccatgttat  ctggtggtt  aggccaggg  ctctccaac  4680
actgtgcca  tgacttgct  tgtgaccct  ggcaagtca  ttaactata  ggtgcctca  4740
ttttccttc  gttaaaatg  ggataataa  actgaccta  ctcaaaggg  agttttgag  4800
catgactaa  gctttttag  aagcatttt  ggatccttc  gcacaggaa  tctcaagac  4860
tgagtattt  ttataatag  aatgtccac  atgaacttg  tacgtccgt  tgtcccaga  4920
gctgtcatt  gtctatatg  ttctccaag  aactgaatg  atccattgg  gaagcggtg  4980
ataactagc  agacaaaat  tgagaatac  taaacaacg  attgccacg  aaacataca  5040
aggatgcct  ttctgtgat  gggtgggat  ttttccctt  ttatgtggg  tatagtagt  5100
acttgtgac  aaaataatt  tggaataat  tctattaat  tcaactctg  agctaattg  5160
actaatctg  gattgtgtt  gttcataat  aaagtgaag  gaatctaaa  aaaaaaaaa  5220
a  5221



<210> 5298
<211> 359
<212> PRT
<213> Homo sapiens
<308> O00767
<400> 5298

Met Pro Ala His Leu Leu Gln Asp Asp Ile Ser Ser Ser Tyr Thr Thr 
  1               5                  10                  15
Thr Thr Thr Ile Thr Ala Pro Pro Ser Arg Val Leu Gln Asn Gly Gly 
             20                  25                  30
Asp Lys Leu Glu Thr Met Pro Leu Tyr Leu Glu Asp Asp Ile Arg Pro 
         35                  40                  45
Asp Ile Lys Asp Asp Ile Tyr Asp Pro Thr Tyr Lys Asp Lys Glu Gly 
     50                  55                  60
Pro Ser Pro Lys Val Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ser 
 65                  70                  75                  80
Leu Leu His Leu Gly Ala Leu Tyr Gly Ile Thr Leu Ile Pro Thr Cys 
                 85                  90                  95
Lys Phe Tyr Thr Trp Leu Trp Gly Val Phe Tyr Tyr Phe Val Ser Ala 
             100                105                110
Leu Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Ser Tyr 
         115                120                125
Lys Ala Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met 
     130                135                140
Ala Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His 
 145                150                155                160
His Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly 
                 165                170                175
Phe Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala 
             180                185                190
Val Lys Glu Lys Gly Ser Thr Leu Asp Leu Ser Asp Leu Glu Ala Glu 
         195                200                205
Lys Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Met 
     210                215                220
Met Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Phe Trp Gly Glu 
 225                230                235                240
Thr Phe Gln Asn Ser Val Phe Val Ala Thr Phe Leu Arg Tyr Ala Val 
                 245                250                255
Val Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Phe Gly 
             260                265                270
Tyr Arg Pro Tyr Asp Lys Asn Ile Ser Pro Arg Glu Asn Ile Leu Val 
         275                280                285
Ser Leu Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ser Phe 
     290                295                300
Pro Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr 
 305                310                315                320
Thr Phe Phe Ile Asp Cys Met Ala Ala Leu Gly Leu Ala Tyr Asp Arg 
                 325                330                335
Lys Lys Val Ser Lys Ala Ala Ile Leu Ala Arg Ile Lys Arg Thr Gly 
             340                345                350
Asp Gly Asn Tyr Lys Ser Gly 
         355



<210> 5299
<211> 552
<212> DNA
<213> Rattus norvegicus
<308> AA875275
<400> 5299

ttttttttt  tttttttga  aacaggatg  tgcattcta  aactttcag  gttttagac  60
atctatgac  tgctgttct  tccatcagc  tagggtaga  gtcaaggcc  tatttgccc  120
tgtattctg  atgccactg  gctttgaaa  gtgaaaaag  aaaaaagaa  aaaaaaaaa  180
gcaaagcaa  ccccagtgg  atagtcagt  ccgtttgtt  tgtttttga  aagcaagac  240
tcccgcttg  ttttaacgt  gagttgaga  cggttttgt  ttttttaaa  aaatcatgg  300
gctgaagca  ttttaggat  gtcggtgct  agtagactt  atgactatt  taaaactgc  360
tgaatttag  gaaaaatct  tttttctca  tctgcatgt  taagtgttt  tagcctggc  420
cctcctcca  ggcanaaag  cctgtgccg  ctaaaggtt  gggtttctt  tcctccagt  480
aaaatcttg  taccttatt  gatgtttac  ttaagatat  acattacac  tggcaatgc  540
aagattttt  tc  552



<210> 5300
<211> 424
<212> DNA
<213> Homo sapiens
<308> AA761673
<400> 5300

ttttttttt  gtgacacga  gctgcattc  aaaactttt  tagttttag  ctatgtatg  60
tgtgttgtt  taatctcca  ccaccatag  atagagtta  aggcattct  tgcaggcat  120
ttttgtatg  cactgtttt  tgaaatgtg  aaaaaacgt  ggcatactt  gttattttt  180
tggacaagc  acacttcaa  cttgttttt  atgttaatt  gatagtgtg  gtttttttt  240
ttaaacaaa  caagaagct  aaaaatttt  aggattgtt  gtgcttagt  gacttgata  300
ctattttaa  aatgcgtga  tttagtaaa  ttctttttt  ctcactatg  atgtgtaaa  360
gtttgtaac  tggcttccc  cttctccag  ggtataaag  attgtgccg  tttaaggtt  420
gggt  424



<210> 5301
<211> 547
<212> DNA
<213> Rattus norvegicus
<308> AA875278
<400> 5301

ttttttttt  tttttttgt  gatgaattg  cttctcttt  ttaagaacc  ttacagaat  60
actcagttc  gaagggggt  acaacacac  catgagcac  aaagattcc  gctcatcct  120
caccggccc  ggatcgaga  gttgtcagg  gtggaggag  agccagggc  tcctctctg  180
tctctgtgg  gacaagatg  cccctgcac  gcctggggt  tgggtggtc  gcgggccag  240
tgtctcatg  ctgcctgca  ggacttctt  aggaaggtg  cgttgggct  tagggccac  300
gccaggtcc  gactctgct  ctgtgagat  ctggcctgg  acttggtca  caccgtcag  360
atcagcttg  cataggcca  ggaggtggt  gctgccggc  cctctttgc  cagcctctg  420
atcaagaca  tgaagagct  cgaggtcat  tccacctgc  gctccagga  cgcctgcaa  480
accaggaac  tctcttccc  ccaggccag  tccaggacc  gccccagaa  ctggacctg  540
atgtctg  547



<210> 5302
<211> 2565
<212> DNA
<213> Homo sapiens
<308> AF265210
<400> 5302

aacggctgc  gcttcgggc  gccgggttt  tccggtctc  caacgccga  gagagcttg  60
aacaggcgc  ggagctggc  cgccaccgc  gcgtcaggg  cggcgctgg  gtcctccgt  120
cccctcagc  tctgagctg  ggccccaca  cagagtagg  ggcggcgcg  cacccgtgc  180
ccggcatgg  gacaccgga  gcggggctc  ctggggctg  gggcgtgga  ccggcgccc  240
gggcgcagc  ggaggcccc  gcccgcctc  tgctgcagg  gctgcaggc  gggcctgag  300
gggcgcggc  cggcctggg  gtgctccgg  cgctgggca  ccgcggctg  gagcccttc  360
actggggtc  cttgctcga  gccctgtgc  gggaggagc  ggtcgtgca  gggcctgac  420
gccgtctgg  gctgaaacc  ctgttgctg  gattgcccc  gatatgcca  aggaacctg  480
tgtccctgc  gatggccgt  cggccatcg  tgccggaaa  tgggctcct  tctgtgctg  540
agattgccc  gcaggacct  gcccctgac  ccgatgcct  gctccgtgc  ctgggggaa  600
tgctgcgaa  ggatttggg  gtggggacc  ccatggagg  agcttctcc  ctgtctgaa  660
gatgccaga  acagctcca  agtctatgt  gggggctgg  cctgggggg  aggaggttg  720
aatcccccc  ggctccaga  cctgaagaa  aggagaaca  ggactccca  cagcctggg  780
aacgcagaa  ggactcaga  gaagaggct  ccagtcctg  ggggaagag  gtccccaaa  840
gattacggt  ttgggaaga  gaagaagat  atgagaagg  gagacccga  cataagtca  900
tggaatccc  ggcagatgg  ggaagtgca  ctcctatta  ggaccagcc  gtcatggca  960
ttaagactg  cgaggacgg  tcgaatctg  atgatgcta  aggtctggc  gagagtttg  1020
agttgccca  agctatcca  gaccagctt  ccaggctgc  gcagctgct  aagaccttg  1080
aggaggggt  agagggatt  gaggatgcc  ccccagttg  gctacagct  cttcacgaa  1140
gtagtccca  ccagatgga  ttgctgtgt  cccagctgc  gctccctca  ctctcagac  1200
tcggtctcc  gcggctctg  acctggctg  tggcccttt  acctgatct  agcctcagc  1260
atgctactg  gctgaccag  agcctcttt  ttggacgga  cctctcctt  acttcctca  1320
cctcccgcc  gcttacaac  gccctgacc  ccttctgtg  caaatatac  taccctgtc  1380
gcagcgccc  ccttgaccc  gtgctccag  ccccaggca  aggtcctgc  caaacagag  1440
tactgtgtt  ccttgtgaa  atggagtcc  tggagccag  tgcacaggt  ctaatgctg  1500
gacagatct  ggagctgcc  tggaaggag  aaactttct  ggtgttgca  tcactccta  1560
agcggcagg  ggagatgac  cctgagaag  tcagtgtct  aatggagaa  ctctgtaaa  1620
aggggctgg  agccaccac  tccatggcc  atgccaagc  catgctgac  gtgatgacc  1680
agtatcagg  taacatcac  gagacccag  ggctgggcc  ggctatggc  ctagaacct  1740
acaccacct  cctgaggaa  tccctgaag  ccgccttga  acatttggg  ccctgacca  1800
ccaccaagg  accaccctc  tggtgctcc  tcaccagct  cctgaaggg  atttctttc  1860
tcaccacct  gtcttgagc  ctagcctga  gataaaggc  gagcctggc  atcccagat  1920
gcaactgcc  ccctgttac  ggctgcata  ggaatattg  cttcccagc  agcagggag  1980
ctcctgggc  aagggagct  agctatatt  tctttttca  ttcttttgt  tttgagaga  2040
ggtattgct  tgtcatcca  gctggagtg  agtgatgcg  ttgatcatg  ctcactgta  2100
cctctgcct  ccaggctcg  tcctcccat  tcagcctcc  aagtagctg  gactacatg  2160
acatgacac  atgcccagc  aatttttta  tttgtagat  atatgctgg  cagggctgg  2220
cttgaactc  tgagctcaa  tgatcttcc  gccttggca  ccaaagtgt  gagatttac  2280
ggtgtgagc  accacacca  gccagagct  tatttccaa  ggctgctgg  cccaggcac  2340
ctcctcatc  attctcagg  tgcagggac  aactttccg  tagggctca  taggatcaa  2400
ccgacccag  gtgggcatg  gatgctcca  gaggtctgg  gtaccagtg  gctcagatg  2460
agctcttgt  ctcatgtat  ttatgacct  ctgtgtttt  gtttctgac  tgaataatt  2520
atcaatggt  ttgaataaa  gcaagttca  taatgaaaa  aaaaa  2565



<210> 5303
<211> 537
<212> PRT
<213> Homo sapiens
<308> AF265210
<400> 5303

Met Ala Thr Pro Asp Ala Gly Leu Pro Gly Ala Glu Gly Val Glu Pro 
  1               5                  10                  15
Ala Pro Trp Ala Gln Leu Glu Ala Pro Ala Arg Leu Leu Leu Gln Ala 
             20                  25                  30
Leu Gln Ala Gly Pro Glu Gly Ala Arg Arg Gly Leu Gly Val Leu Arg 
         35                  40                  45
Ala Leu Gly Ser Arg Gly Trp Glu Pro Phe Asp Trp Gly Arg Leu Leu 
     50                  55                  60
Glu Ala Leu Cys Arg Glu Glu Pro Val Val Gln Gly Pro Asp Gly Arg 
 65                  70                  75                  80
Leu Glu Leu Lys Pro Leu Leu Leu Arg Leu Pro Arg Ile Cys Gln Arg 
                 85                  90                  95
Asn Leu Met Ser Leu Leu Met Ala Val Arg Pro Ser Leu Pro Glu Ser 
             100                105                110
Gly Leu Leu Ser Val Leu Gln Ile Ala Gln Gln Asp Leu Ala Pro Asp 
         115                120                125
Pro Asp Ala Trp Leu Arg Ala Leu Gly Glu Leu Leu Arg Arg Asp Leu 
     130                135                140
Gly Val Gly Thr Ser Met Glu Gly Ala Ser Pro Leu Ser Glu Arg Cys 
 145                150                155                160
Gln Arg Gln Leu Gln Ser Leu Cys Arg Gly Leu Gly Leu Gly Gly Arg 
                 165                170                175
Arg Leu Lys Ser Pro Gln Ala Pro Asp Pro Glu Glu Glu Glu Asn Arg 
             180                185                190
Asp Ser Gln Gln Pro Gly Lys Arg Arg Lys Asp Ser Glu Glu Glu Ala 
         195                200                205
Ala Ser Pro Glu Gly Lys Arg Val Pro Lys Arg Leu Arg Cys Trp Glu 
     210                215                220
Glu Glu Glu Asp His Glu Lys Glu Arg Pro Glu His Lys Ser Leu Glu 
 225                230                235                240
Ser Leu Ala Asp Gly Gly Ser Ala Ser Pro Ile Lys Asp Gln Pro Val 
                 245                250                255
Met Ala Val Lys Thr Gly Glu Asp Gly Ser Asn Leu Asp Asp Ala Lys 
             260                265                270
Gly Leu Ala Glu Ser Leu Glu Leu Pro Lys Ala Ile Gln Asp Gln Leu 
         275                280                285
Pro Arg Leu Gln Gln Leu Leu Lys Thr Leu Glu Glu Gly Leu Glu Gly 
     290                295                300
Leu Glu Asp Ala Pro Pro Val Glu Leu Gln Leu Leu His Glu Cys Ser 
 305                310                315                320
Pro Ser Gln Met Asp Leu Leu Cys Ala Gln Leu Gln Leu Pro Gln Leu 
                 325                330                335
Ser Asp Leu Gly Leu Leu Arg Leu Cys Thr Trp Leu Leu Ala Leu Ser 
             340                345                350
Pro Asp Leu Ser Leu Ser Asn Ala Thr Val Leu Thr Arg Ser Leu Phe 
         355                360                365
Leu Gly Arg Ile Leu Ser Leu Thr Ser Ser Ala Ser Arg Leu Leu Thr 
     370                375                380
Thr Ala Leu Thr Ser Phe Cys Ala Lys Tyr Thr Tyr Pro Val Cys Ser 
 385                390                395                400
Ala Leu Leu Asp Pro Val Leu Gln Ala Pro Gly Thr Gly Pro Ala Gln 
                 405                410                415
Thr Glu Leu Leu Cys Cys Leu Val Lys Met Glu Ser Leu Glu Pro Asp 
             420                425                430
Ala Gln Val Leu Met Leu Gly Gln Ile Leu Glu Leu Pro Trp Lys Glu 
         435                440                445
Glu Thr Phe Leu Val Leu Gln Ser Leu Leu Glu Arg Gln Val Glu Met 
     450                455                460
Thr Pro Glu Lys Phe Ser Val Leu Met Glu Lys Leu Cys Lys Lys Gly 
 465                470                475                480
Leu Ala Ala Thr Thr Ser Met Ala Tyr Ala Lys Leu Met Leu Thr Val 
                 485                490                495
Met Thr Lys Tyr Gln Ala Asn Ile Thr Glu Thr Gln Arg Leu Gly Leu 
             500                505                510
Ala Met Ala Leu Glu Pro Asn Thr Thr Phe Leu Arg Lys Ser Leu Lys 
         515                520                525
Ala Ala Leu Lys His Leu Gly Pro Ter 
     530                535



<210> 5304
<211> 547
<212> DNA
<213> Rattus norvegicus
<308> AA875278
<400> 5304

ttttttttt  tttttttgt  gatgaattg  cttctcttt  ttaagaacc  ttacagaat  60
actcagttc  gaagggggt  acaacacac  catgagcac  aaagattcc  gctcatcct  120
caccggccc  ggatcgaga  gttgtcagg  gtggaggag  agccagggc  tcctctctg  180
tctctgtgg  gacaagatg  cccctgcac  gcctggggt  tgggtggtc  gcgggccag  240
tgtctcatg  ctgcctgca  ggacttctt  aggaaggtg  cgttgggct  tagggccac  300
gccaggtcc  gactctgct  ctgtgagat  ctggcctgg  acttggtca  caccgtcag  360
atcagcttg  cataggcca  ggaggtggt  gctgccggc  cctctttgc  cagcctctg  420
atcaagaca  tgaagagct  cgaggtcat  tccacctgc  gctccagga  cgcctgcaa  480
accaggaac  tctcttccc  ccaggccag  tccaggacc  gccccagaa  ctggacctg  540
atgtctg  547



<210> 5305
<211> 2565
<212> DNA
<213> Homo sapiens
<308> AF265210
<400> 5305

aacggctgc  gcttcgggc  gccgggttt  tccggtctc  caacgccga  gagagcttg  60
aacaggcgc  ggagctggc  cgccaccgc  gcgtcaggg  cggcgctgg  gtcctccgt  120
cccctcagc  tctgagctg  ggccccaca  cagagtagg  ggcggcgcg  cacccgtgc  180
ccggcatgg  gacaccgga  gcggggctc  ctggggctg  gggcgtgga  ccggcgccc  240
gggcgcagc  ggaggcccc  gcccgcctc  tgctgcagg  gctgcaggc  gggcctgag  300
gggcgcggc  cggcctggg  gtgctccgg  cgctgggca  ccgcggctg  gagcccttc  360
actggggtc  cttgctcga  gccctgtgc  gggaggagc  ggtcgtgca  gggcctgac  420
gccgtctgg  gctgaaacc  ctgttgctg  gattgcccc  gatatgcca  aggaacctg  480
tgtccctgc  gatggccgt  cggccatcg  tgccggaaa  tgggctcct  tctgtgctg  540
agattgccc  gcaggacct  gcccctgac  ccgatgcct  gctccgtgc  ctgggggaa  600
tgctgcgaa  ggatttggg  gtggggacc  ccatggagg  agcttctcc  ctgtctgaa  660
gatgccaga  acagctcca  agtctatgt  gggggctgg  cctgggggg  aggaggttg  720
aatcccccc  ggctccaga  cctgaagaa  aggagaaca  ggactccca  cagcctggg  780
aacgcagaa  ggactcaga  gaagaggct  ccagtcctg  ggggaagag  gtccccaaa  840
gattacggt  ttgggaaga  gaagaagat  atgagaagg  gagacccga  cataagtca  900
tggaatccc  ggcagatgg  ggaagtgca  ctcctatta  ggaccagcc  gtcatggca  960
ttaagactg  cgaggacgg  tcgaatctg  atgatgcta  aggtctggc  gagagtttg  1020
agttgccca  agctatcca  gaccagctt  ccaggctgc  gcagctgct  aagaccttg  1080
aggaggggt  agagggatt  gaggatgcc  ccccagttg  gctacagct  cttcacgaa  1140
gtagtccca  ccagatgga  ttgctgtgt  cccagctgc  gctccctca  ctctcagac  1200
tcggtctcc  gcggctctg  acctggctg  tggcccttt  acctgatct  agcctcagc  1260
atgctactg  gctgaccag  agcctcttt  ttggacgga  cctctcctt  acttcctca  1320
cctcccgcc  gcttacaac  gccctgacc  ccttctgtg  caaatatac  taccctgtc  1380
gcagcgccc  ccttgaccc  gtgctccag  ccccaggca  aggtcctgc  caaacagag  1440
tactgtgtt  ccttgtgaa  atggagtcc  tggagccag  tgcacaggt  ctaatgctg  1500
gacagatct  ggagctgcc  tggaaggag  aaactttct  ggtgttgca  tcactccta  1560
agcggcagg  ggagatgac  cctgagaag  tcagtgtct  aatggagaa  ctctgtaaa  1620
aggggctgg  agccaccac  tccatggcc  atgccaagc  catgctgac  gtgatgacc  1680
agtatcagg  taacatcac  gagacccag  ggctgggcc  ggctatggc  ctagaacct  1740
acaccacct  cctgaggaa  tccctgaag  ccgccttga  acatttggg  ccctgacca  1800
ccaccaagg  accaccctc  tggtgctcc  tcaccagct  cctgaaggg  atttctttc  1860
tcaccacct  gtcttgagc  ctagcctga  gataaaggc  gagcctggc  atcccagat  1920
gcaactgcc  ccctgttac  ggctgcata  ggaatattg  cttcccagc  agcagggag  1980
ctcctgggc  aagggagct  agctatatt  tctttttca  ttcttttgt  tttgagaga  2040
ggtattgct  tgtcatcca  gctggagtg  agtgatgcg  ttgatcatg  ctcactgta  2100
cctctgcct  ccaggctcg  tcctcccat  tcagcctcc  aagtagctg  gactacatg  2160
acatgacac  atgcccagc  aatttttta  tttgtagat  atatgctgg  cagggctgg  2220
cttgaactc  tgagctcaa  tgatcttcc  gccttggca  ccaaagtgt  gagatttac  2280
ggtgtgagc  accacacca  gccagagct  tatttccaa  ggctgctgg  cccaggcac  2340
ctcctcatc  attctcagg  tgcagggac  aactttccg  tagggctca  taggatcaa  2400
ccgacccag  gtgggcatg  gatgctcca  gaggtctgg  gtaccagtg  gctcagatg  2460
agctcttgt  ctcatgtat  ttatgacct  ctgtgtttt  gtttctgac  tgaataatt  2520
atcaatggt  ttgaataaa  gcaagttca  taatgaaaa  aaaaa  2565



<210> 5306
<211> 537
<212> PRT
<213> Homo sapiens
<308> AF265210
<400> 5306

Met Ala Thr Pro Asp Ala Gly Leu Pro Gly Ala Glu Gly Val Glu Pro 
  1               5                  10                  15
Ala Pro Trp Ala Gln Leu Glu Ala Pro Ala Arg Leu Leu Leu Gln Ala 
             20                  25                  30
Leu Gln Ala Gly Pro Glu Gly Ala Arg Arg Gly Leu Gly Val Leu Arg 
         35                  40                  45
Ala Leu Gly Ser Arg Gly Trp Glu Pro Phe Asp Trp Gly Arg Leu Leu 
     50                  55                  60
Glu Ala Leu Cys Arg Glu Glu Pro Val Val Gln Gly Pro Asp Gly Arg 
 65                  70                  75                  80
Leu Glu Leu Lys Pro Leu Leu Leu Arg Leu Pro Arg Ile Cys Gln Arg 
                 85                  90                  95
Asn Leu Met Ser Leu Leu Met Ala Val Arg Pro Ser Leu Pro Glu Ser 
             100                105                110
Gly Leu Leu Ser Val Leu Gln Ile Ala Gln Gln Asp Leu Ala Pro Asp 
         115                120                125
Pro Asp Ala Trp Leu Arg Ala Leu Gly Glu Leu Leu Arg Arg Asp Leu 
     130                135                140
Gly Val Gly Thr Ser Met Glu Gly Ala Ser Pro Leu Ser Glu Arg Cys 
 145                150                155                160
Gln Arg Gln Leu Gln Ser Leu Cys Arg Gly Leu Gly Leu Gly Gly Arg 
                 165                170                175
Arg Leu Lys Ser Pro Gln Ala Pro Asp Pro Glu Glu Glu Glu Asn Arg 
             180                185                190
Asp Ser Gln Gln Pro Gly Lys Arg Arg Lys Asp Ser Glu Glu Glu Ala 
         195                200                205
Ala Ser Pro Glu Gly Lys Arg Val Pro Lys Arg Leu Arg Cys Trp Glu 
     210                215                220
Glu Glu Glu Asp His Glu Lys Glu Arg Pro Glu His Lys Ser Leu Glu 
 225                230                235                240
Ser Leu Ala Asp Gly Gly Ser Ala Ser Pro Ile Lys Asp Gln Pro Val 
                 245                250                255
Met Ala Val Lys Thr Gly Glu Asp Gly Ser Asn Leu Asp Asp Ala Lys 
             260                265                270
Gly Leu Ala Glu Ser Leu Glu Leu Pro Lys Ala Ile Gln Asp Gln Leu 
         275                280                285
Pro Arg Leu Gln Gln Leu Leu Lys Thr Leu Glu Glu Gly Leu Glu Gly 
     290                295                300
Leu Glu Asp Ala Pro Pro Val Glu Leu Gln Leu Leu His Glu Cys Ser 
 305                310                315                320
Pro Ser Gln Met Asp Leu Leu Cys Ala Gln Leu Gln Leu Pro Gln Leu 
                 325                330                335
Ser Asp Leu Gly Leu Leu Arg Leu Cys Thr Trp Leu Leu Ala Leu Ser 
             340                345                350
Pro Asp Leu Ser Leu Ser Asn Ala Thr Val Leu Thr Arg Ser Leu Phe 
         355                360                365
Leu Gly Arg Ile Leu Ser Leu Thr Ser Ser Ala Ser Arg Leu Leu Thr 
     370                375                380
Thr Ala Leu Thr Ser Phe Cys Ala Lys Tyr Thr Tyr Pro Val Cys Ser 
 385                390                395                400
Ala Leu Leu Asp Pro Val Leu Gln Ala Pro Gly Thr Gly Pro Ala Gln 
                 405                410                415
Thr Glu Leu Leu Cys Cys Leu Val Lys Met Glu Ser Leu Glu Pro Asp 
             420                425                430
Ala Gln Val Leu Met Leu Gly Gln Ile Leu Glu Leu Pro Trp Lys Glu 
         435                440                445
Glu Thr Phe Leu Val Leu Gln Ser Leu Leu Glu Arg Gln Val Glu Met 
     450                455                460
Thr Pro Glu Lys Phe Ser Val Leu Met Glu Lys Leu Cys Lys Lys Gly 
 465                470                475                480
Leu Ala Ala Thr Thr Ser Met Ala Tyr Ala Lys Leu Met Leu Thr Val 
                 485                490                495
Met Thr Lys Tyr Gln Ala Asn Ile Thr Glu Thr Gln Arg Leu Gly Leu 
             500                505                510
Ala Met Ala Leu Glu Pro Asn Thr Thr Phe Leu Arg Lys Ser Leu Lys 
         515                520                525
Ala Ala Leu Lys His Leu Gly Pro Ter 
     530                535



<210> 5307
<211> 394
<212> DNA
<213> Rattus norvegicus
<308> AA875327
<400> 5307

ttttttttt  tttttttgt  atgtaaggt  ctcttttat  taaaagatc  ttcacaaaa  60
accatatcc  tagactcac  ttctgtcat  gaactgaat  tgttaagtg  ttggaattc  120
attcttaca  agtcagctg  gcgcccagc  gtgtggatg  acgtgcctg  tctgtcttt  180
ccgcattgg  gatggatta  atcatctga  agcatcagc  ttgattaca  ccacgcaat  240
catgtctcc  attctgtgt  ctcatccca  ctggatacc  accaacagg  caccacagc  300
gcctagcta  tggccccag  tctttccca  aagccaagg  gtggctggc  ggaagctgc  360
ggctaacga  caagctgcg  acctcagcc  ttct  394



<210> 5308
<211> 647
<212> PRT
<213> Rattus norvegicus
<308> AAD34858
<400> 5308

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Glu Cys Ser Val Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu His Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Ala Cys Gly Asn Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly Gln Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ala His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Ser Leu Gly His Gly Pro Val Ser Asp Pro Ser Pro 
             260                265                270
Leu Ser Ser Pro Val His Thr Pro Ser Gly Gln Ala Ala Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Thr Ser Pro Gly 
     290                295                300
Thr Ser Ser Leu Ala Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Asn Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Arg Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Ile Asp Glu Lys Asn Gln Ser Glu Asp Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu Gln Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ser Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Glu Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Ser Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 5309
<211> 2477
<212> DNA
<213> Homo sapiens
<308> D26068
<400> 5309

gacggcaaa  ggcggactt  gacacctac  acgatcggg  ctacagcag  ttcggcggc  60
gcagagggt  ccgcggcag  gctggtggc  atggttccc  tagccagaa  gagttgccc  120
cagagcccc  ctacacagc  tacgtagga  atctacctt  caatacggt  cagggcgac  180
tagatgcta  ctttaagga  ctcagcata  ggagtgtac  gctagtcag  gacaaagac  240
cagataaat  taaaggatt  tgctatgta  aattcgatg  agtggattc  cttaaggaa  300
ccttgacat  cgatggtgc  ctgttgggc  atcggtcac  tcgtgtgga  attgcagaa  360
gcagaaaac  agataaagg  ggctttgga  tcagaaaag  tggaccaga  gacagaggc  420
tcagggatg  cttcttagg  ggcagggga  gtagtcgcc  aggcgaccg  cgaacaggc  480
cccccatgg  cagccgctt  agagatggc  ctcccctcc  tggatccaa  atggatttc  540
gagaaccca  agaagagga  agagcacag  gaccacgac  ccagcttaa  cctcgaaca  600
tcgcgacgc  cctcaatca  gtagccaat  ccaactctg  tatcttcgg  ggtgccagg  660
ctagagagg  agtcgttca  aaggagcaa  aatgagcct  cggttggga  ggaatgggg  720
gtggggggt  agagcagga  cacagcctg  tgagtcccc  ggcagccgt  ctgcagccg  780
cactcctgc  cctgccatt  gcctcctca  agcggaaac  cagcttgtg  gtgcatgtc  840
gctgttaac  agtggtttt  agtacattc  gggctttgc  gtatctatc  agtgcctgt  900
tgtgcgttt  tttctttct  ccgctgctt  cccattttc  ttctgtcct  tttctcctg  960
tccttgttt  cccagcagc  catggggtt  ctcggagga  cagaggtgg  cgccgtggg  1020
gggcgtttg  gctgcggtg  tgcgtcatt  ttcctttgc  ttctcttta  tttagacac  1080
ggcccaact  caggcgttt  ctttcattc  ctcagtgct  ctcttctga  ctgcatgtt  1140
agttctgta  tgctggggc  tccaacaaa  accagagtc  ctgacagag  gaacagcag  1200
gaccttgtt  gtattcagc  gtgatggat  tagagaatc  gaggcacct  gttttcaca  1260
ctaggataa  aatatctgc  gggtccttt  cattcctat  tagagggag  cctggctcc  1320
tgaccccct  ccgagtgga  tgtccaagc  gataggctc  cacgagaaa  agtgaggct  1380
aaagggggg  ctatggaag  gcggtaggg  gtccacgga  aagatgcag  gaatgcttg  1440
atgcattca  acgtgtgtg  gtcccagct  gttcactcc  ttcgccgtg  gtggtggag  1500
ctggcctct  tggctgggt  cagtgaatg  ccagcgggt  tcttttctg  tgggccaag  1560
cgctttggg  gtggagggg  tggtgctgg  gctgcactg  gctgactgc  gcgctgacg  1620
agcgtttcc  cccatccct  ttgcctgtg  gttgtgtgg  tctgttcct  gtataggca  1680
cataatgag  tactgtgct  cccacctcc  cttcagttc  gagccaaaa  gggtctaga  1740
tctggcttt  ctcatttcc  ttgataaat  gtactatgc  gagctgtca  gaaccttca  1800
atagcagta  aggactgca  ctgtctagg  ctgcggcca  atcttgggg  cacactgga  1860
tgttcccat  tgcagggtt  agcagttat  tgggagtgc  aggggttag  cttttgagc  1920
tgaacgcct  cgtgtgaac  gatgaaaaa  ccttcagta  ccaagtccc  gtctgtcct  1980
tggggagca  tttgggggc  gccggcagc  ggagcctgg  aaagaggcc  tcgccaggt  2040
atggcaggg  cagggtggc  tggggcacc  agcggaatg  gcttagtat  tggtcacca  2100
ccgtcatcc  gggcttttc  tactgtgtc  tgttacaag  cctcagcaa  ccacagaac  2160
ctctctcct  ccttccacc  gtcagcttc  ctgcttctg  gataagaac  atttgtgta  2220
caccaacac  taacttcag  aagacatgc  ttatgtggt  taatcaaac  cgatgcttt  2280
agatgacct  cttacatct  caatgtgga  aagataaag  acaaaacac  tgcatctaa  2340
ctgctgggc  atccagttg  cttttaaat  taagaatgg  attccaaac  cttaacaca  2400
tcagctata  gacagaaag  aaatctatg  atatggtat  ttgtgaatg  tcttttaaa  2460
aaaagaaaa  cttacgt  2477



<210> 5310
<211> 248
<212> PRT
<213> Homo sapiens
<308> Q15056
<400> 5310

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
  1               5                  10                  15
Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
             20                  25                  30
Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
         35                  40                  45
Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
     50                  55                  60
Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
 65                  70                  75                  80
Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                 85                  90                  95
Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
             100                105                110
Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
         115                120                125
Arg Lys Gly Gly Pro Asp Asp Arg Gly Met Gly Ser Ser Arg Glu Ser 
     130                135                140
Arg Gly Gly Trp Asp Ser Arg Asp Asp Phe Asn Ser Gly Phe Arg Asp 
 145                150                155                160
Asp Phe Leu Gly Gly Arg Gly Gly Ser Arg Pro Gly Asp Arg Arg Thr 
                 165                170                175
Gly Pro Pro Met Gly Ser Arg Phe Arg Asp Gly Pro Pro Leu Arg Gly 
             180                185                190
Ser Asn Met Asp Phe Arg Glu Pro Thr Glu Glu Glu Arg Ala Gln Arg 
         195                200                205
Pro Arg Leu Gln Leu Lys Pro Arg Thr Val Ala Thr Pro Leu Asn Gln 
     210                215                220
Val Ala Asn Pro Asn Ser Ala Ile Phe Gly Gly Ala Arg Pro Arg Glu 
 225                230                235                240
Glu Val Val Gln Lys Glu Gln Glu 
                 245



<210> 5311
<211> 394
<212> DNA
<213> Rattus norvegicus
<308> AA875327
<400> 5311

ttttttttt  tttttttgt  atgtaaggt  ctcttttat  taaaagatc  ttcacaaaa  60
accatatcc  tagactcac  ttctgtcat  gaactgaat  tgttaagtg  ttggaattc  120
attcttaca  agtcagctg  gcgcccagc  gtgtggatg  acgtgcctg  tctgtcttt  180
ccgcattgg  gatggatta  atcatctga  agcatcagc  ttgattaca  ccacgcaat  240
catgtctcc  attctgtgt  ctcatccca  ctggatacc  accaacagg  caccacagc  300
gcctagcta  tggccccag  tctttccca  aagccaagg  gtggctggc  ggaagctgc  360
ggctaacga  caagctgcg  acctcagcc  ttct  394



<210> 5312
<211> 647
<212> PRT
<213> Rattus norvegicus
<308> AAD34858
<400> 5312

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Glu Cys Ser Val Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu His Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Ala Cys Gly Asn Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly Gln Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ala His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Ser Leu Gly His Gly Pro Val Ser Asp Pro Ser Pro 
             260                265                270
Leu Ser Ser Pro Val His Thr Pro Ser Gly Gln Ala Ala Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Thr Ser Pro Gly 
     290                295                300
Thr Ser Ser Leu Ala Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Asn Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Arg Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Ile Asp Glu Lys Asn Gln Ser Glu Asp Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu Gln Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ser Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Glu Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Ser Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 5313
<211> 2477
<212> DNA
<213> Homo sapiens
<308> D26068
<400> 5313

gacggcaaa  ggcggactt  gacacctac  acgatcggg  ctacagcag  ttcggcggc  60
gcagagggt  ccgcggcag  gctggtggc  atggttccc  tagccagaa  gagttgccc  120
cagagcccc  ctacacagc  tacgtagga  atctacctt  caatacggt  cagggcgac  180
tagatgcta  ctttaagga  ctcagcata  ggagtgtac  gctagtcag  gacaaagac  240
cagataaat  taaaggatt  tgctatgta  aattcgatg  agtggattc  cttaaggaa  300
ccttgacat  cgatggtgc  ctgttgggc  atcggtcac  tcgtgtgga  attgcagaa  360
gcagaaaac  agataaagg  ggctttgga  tcagaaaag  tggaccaga  gacagaggc  420
tcagggatg  cttcttagg  ggcagggga  gtagtcgcc  aggcgaccg  cgaacaggc  480
cccccatgg  cagccgctt  agagatggc  ctcccctcc  tggatccaa  atggatttc  540
gagaaccca  agaagagga  agagcacag  gaccacgac  ccagcttaa  cctcgaaca  600
tcgcgacgc  cctcaatca  gtagccaat  ccaactctg  tatcttcgg  ggtgccagg  660
ctagagagg  agtcgttca  aaggagcaa  aatgagcct  cggttggga  ggaatgggg  720
gtggggggt  agagcagga  cacagcctg  tgagtcccc  ggcagccgt  ctgcagccg  780
cactcctgc  cctgccatt  gcctcctca  agcggaaac  cagcttgtg  gtgcatgtc  840
gctgttaac  agtggtttt  agtacattc  gggctttgc  gtatctatc  agtgcctgt  900
tgtgcgttt  tttctttct  ccgctgctt  cccattttc  ttctgtcct  tttctcctg  960
tccttgttt  cccagcagc  catggggtt  ctcggagga  cagaggtgg  cgccgtggg  1020
gggcgtttg  gctgcggtg  tgcgtcatt  ttcctttgc  ttctcttta  tttagacac  1080
ggcccaact  caggcgttt  ctttcattc  ctcagtgct  ctcttctga  ctgcatgtt  1140
agttctgta  tgctggggc  tccaacaaa  accagagtc  ctgacagag  gaacagcag  1200
gaccttgtt  gtattcagc  gtgatggat  tagagaatc  gaggcacct  gttttcaca  1260
ctaggataa  aatatctgc  gggtccttt  cattcctat  tagagggag  cctggctcc  1320
tgaccccct  ccgagtgga  tgtccaagc  gataggctc  cacgagaaa  agtgaggct  1380
aaagggggg  ctatggaag  gcggtaggg  gtccacgga  aagatgcag  gaatgcttg  1440
atgcattca  acgtgtgtg  gtcccagct  gttcactcc  ttcgccgtg  gtggtggag  1500
ctggcctct  tggctgggt  cagtgaatg  ccagcgggt  tcttttctg  tgggccaag  1560
cgctttggg  gtggagggg  tggtgctgg  gctgcactg  gctgactgc  gcgctgacg  1620
agcgtttcc  cccatccct  ttgcctgtg  gttgtgtgg  tctgttcct  gtataggca  1680
cataatgag  tactgtgct  cccacctcc  cttcagttc  gagccaaaa  gggtctaga  1740
tctggcttt  ctcatttcc  ttgataaat  gtactatgc  gagctgtca  gaaccttca  1800
atagcagta  aggactgca  ctgtctagg  ctgcggcca  atcttgggg  cacactgga  1860
tgttcccat  tgcagggtt  agcagttat  tgggagtgc  aggggttag  cttttgagc  1920
tgaacgcct  cgtgtgaac  gatgaaaaa  ccttcagta  ccaagtccc  gtctgtcct  1980
tggggagca  tttgggggc  gccggcagc  ggagcctgg  aaagaggcc  tcgccaggt  2040
atggcaggg  cagggtggc  tggggcacc  agcggaatg  gcttagtat  tggtcacca  2100
ccgtcatcc  gggcttttc  tactgtgtc  tgttacaag  cctcagcaa  ccacagaac  2160
ctctctcct  ccttccacc  gtcagcttc  ctgcttctg  gataagaac  atttgtgta  2220
caccaacac  taacttcag  aagacatgc  ttatgtggt  taatcaaac  cgatgcttt  2280
agatgacct  cttacatct  caatgtgga  aagataaag  acaaaacac  tgcatctaa  2340
ctgctgggc  atccagttg  cttttaaat  taagaatgg  attccaaac  cttaacaca  2400
tcagctata  gacagaaag  aaatctatg  atatggtat  ttgtgaatg  tcttttaaa  2460
aaaagaaaa  cttacgt  2477



<210> 5314
<211> 248
<212> PRT
<213> Homo sapiens
<308> Q15056
<400> 5314

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
  1               5                  10                  15
Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
             20                  25                  30
Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
         35                  40                  45
Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
     50                  55                  60
Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
 65                  70                  75                  80
Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                 85                  90                  95
Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
             100                105                110
Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
         115                120                125
Arg Lys Gly Gly Pro Asp Asp Arg Gly Met Gly Ser Ser Arg Glu Ser 
     130                135                140
Arg Gly Gly Trp Asp Ser Arg Asp Asp Phe Asn Ser Gly Phe Arg Asp 
 145                150                155                160
Asp Phe Leu Gly Gly Arg Gly Gly Ser Arg Pro Gly Asp Arg Arg Thr 
                 165                170                175
Gly Pro Pro Met Gly Ser Arg Phe Arg Asp Gly Pro Pro Leu Arg Gly 
             180                185                190
Ser Asn Met Asp Phe Arg Glu Pro Thr Glu Glu Glu Arg Ala Gln Arg 
         195                200                205
Pro Arg Leu Gln Leu Lys Pro Arg Thr Val Ala Thr Pro Leu Asn Gln 
     210                215                220
Val Ala Asn Pro Asn Ser Ala Ile Phe Gly Gly Ala Arg Pro Arg Glu 
 225                230                235                240
Glu Val Val Gln Lys Glu Gln Glu 
                 245



<210> 5315
<211> 394
<212> DNA
<213> Rattus norvegicus
<308> AA875327
<400> 5315

ttttttttt  tttttttgt  atgtaaggt  ctcttttat  taaaagatc  ttcacaaaa  60
accatatcc  tagactcac  ttctgtcat  gaactgaat  tgttaagtg  ttggaattc  120
attcttaca  agtcagctg  gcgcccagc  gtgtggatg  acgtgcctg  tctgtcttt  180
ccgcattgg  gatggatta  atcatctga  agcatcagc  ttgattaca  ccacgcaat  240
catgtctcc  attctgtgt  ctcatccca  ctggatacc  accaacagg  caccacagc  300
gcctagcta  tggccccag  tctttccca  aagccaagg  gtggctggc  ggaagctgc  360
ggctaacga  caagctgcg  acctcagcc  ttct  394



<210> 5316
<211> 647
<212> PRT
<213> Rattus norvegicus
<308> AAD34858
<400> 5316

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Glu Cys Ser Val Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu His Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Ala Cys Gly Asn Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly Gln Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ala His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Ser Leu Gly His Gly Pro Val Ser Asp Pro Ser Pro 
             260                265                270
Leu Ser Ser Pro Val His Thr Pro Ser Gly Gln Ala Ala Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Thr Ser Pro Gly 
     290                295                300
Thr Ser Ser Leu Ala Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Asn Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Arg Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Ile Asp Glu Lys Asn Gln Ser Glu Asp Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu Gln Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ser Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Glu Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Ser Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 5317
<211> 2477
<212> DNA
<213> Homo sapiens
<308> D26068
<400> 5317

gacggcaaa  ggcggactt  gacacctac  acgatcggg  ctacagcag  ttcggcggc  60
gcagagggt  ccgcggcag  gctggtggc  atggttccc  tagccagaa  gagttgccc  120
cagagcccc  ctacacagc  tacgtagga  atctacctt  caatacggt  cagggcgac  180
tagatgcta  ctttaagga  ctcagcata  ggagtgtac  gctagtcag  gacaaagac  240
cagataaat  taaaggatt  tgctatgta  aattcgatg  agtggattc  cttaaggaa  300
ccttgacat  cgatggtgc  ctgttgggc  atcggtcac  tcgtgtgga  attgcagaa  360
gcagaaaac  agataaagg  ggctttgga  tcagaaaag  tggaccaga  gacagaggc  420
tcagggatg  cttcttagg  ggcagggga  gtagtcgcc  aggcgaccg  cgaacaggc  480
cccccatgg  cagccgctt  agagatggc  ctcccctcc  tggatccaa  atggatttc  540
gagaaccca  agaagagga  agagcacag  gaccacgac  ccagcttaa  cctcgaaca  600
tcgcgacgc  cctcaatca  gtagccaat  ccaactctg  tatcttcgg  ggtgccagg  660
ctagagagg  agtcgttca  aaggagcaa  aatgagcct  cggttggga  ggaatgggg  720
gtggggggt  agagcagga  cacagcctg  tgagtcccc  ggcagccgt  ctgcagccg  780
cactcctgc  cctgccatt  gcctcctca  agcggaaac  cagcttgtg  gtgcatgtc  840
gctgttaac  agtggtttt  agtacattc  gggctttgc  gtatctatc  agtgcctgt  900
tgtgcgttt  tttctttct  ccgctgctt  cccattttc  ttctgtcct  tttctcctg  960
tccttgttt  cccagcagc  catggggtt  ctcggagga  cagaggtgg  cgccgtggg  1020
gggcgtttg  gctgcggtg  tgcgtcatt  ttcctttgc  ttctcttta  tttagacac  1080
ggcccaact  caggcgttt  ctttcattc  ctcagtgct  ctcttctga  ctgcatgtt  1140
agttctgta  tgctggggc  tccaacaaa  accagagtc  ctgacagag  gaacagcag  1200
gaccttgtt  gtattcagc  gtgatggat  tagagaatc  gaggcacct  gttttcaca  1260
ctaggataa  aatatctgc  gggtccttt  cattcctat  tagagggag  cctggctcc  1320
tgaccccct  ccgagtgga  tgtccaagc  gataggctc  cacgagaaa  agtgaggct  1380
aaagggggg  ctatggaag  gcggtaggg  gtccacgga  aagatgcag  gaatgcttg  1440
atgcattca  acgtgtgtg  gtcccagct  gttcactcc  ttcgccgtg  gtggtggag  1500
ctggcctct  tggctgggt  cagtgaatg  ccagcgggt  tcttttctg  tgggccaag  1560
cgctttggg  gtggagggg  tggtgctgg  gctgcactg  gctgactgc  gcgctgacg  1620
agcgtttcc  cccatccct  ttgcctgtg  gttgtgtgg  tctgttcct  gtataggca  1680
cataatgag  tactgtgct  cccacctcc  cttcagttc  gagccaaaa  gggtctaga  1740
tctggcttt  ctcatttcc  ttgataaat  gtactatgc  gagctgtca  gaaccttca  1800
atagcagta  aggactgca  ctgtctagg  ctgcggcca  atcttgggg  cacactgga  1860
tgttcccat  tgcagggtt  agcagttat  tgggagtgc  aggggttag  cttttgagc  1920
tgaacgcct  cgtgtgaac  gatgaaaaa  ccttcagta  ccaagtccc  gtctgtcct  1980
tggggagca  tttgggggc  gccggcagc  ggagcctgg  aaagaggcc  tcgccaggt  2040
atggcaggg  cagggtggc  tggggcacc  agcggaatg  gcttagtat  tggtcacca  2100
ccgtcatcc  gggcttttc  tactgtgtc  tgttacaag  cctcagcaa  ccacagaac  2160
ctctctcct  ccttccacc  gtcagcttc  ctgcttctg  gataagaac  atttgtgta  2220
caccaacac  taacttcag  aagacatgc  ttatgtggt  taatcaaac  cgatgcttt  2280
agatgacct  cttacatct  caatgtgga  aagataaag  acaaaacac  tgcatctaa  2340
ctgctgggc  atccagttg  cttttaaat  taagaatgg  attccaaac  cttaacaca  2400
tcagctata  gacagaaag  aaatctatg  atatggtat  ttgtgaatg  tcttttaaa  2460
aaaagaaaa  cttacgt  2477



<210> 5318
<211> 248
<212> PRT
<213> Homo sapiens
<308> Q15056
<400> 5318

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
  1               5                  10                  15
Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
             20                  25                  30
Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
         35                  40                  45
Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
     50                  55                  60
Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
 65                  70                  75                  80
Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                 85                  90                  95
Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
             100                105                110
Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
         115                120                125
Arg Lys Gly Gly Pro Asp Asp Arg Gly Met Gly Ser Ser Arg Glu Ser 
     130                135                140
Arg Gly Gly Trp Asp Ser Arg Asp Asp Phe Asn Ser Gly Phe Arg Asp 
 145                150                155                160
Asp Phe Leu Gly Gly Arg Gly Gly Ser Arg Pro Gly Asp Arg Arg Thr 
                 165                170                175
Gly Pro Pro Met Gly Ser Arg Phe Arg Asp Gly Pro Pro Leu Arg Gly 
             180                185                190
Ser Asn Met Asp Phe Arg Glu Pro Thr Glu Glu Glu Arg Ala Gln Arg 
         195                200                205
Pro Arg Leu Gln Leu Lys Pro Arg Thr Val Ala Thr Pro Leu Asn Gln 
     210                215                220
Val Ala Asn Pro Asn Ser Ala Ile Phe Gly Gly Ala Arg Pro Arg Glu 
 225                230                235                240
Glu Val Val Gln Lys Glu Gln Glu 
                 245



<210> 5319
<211> 394
<212> DNA
<213> Rattus norvegicus
<308> AA875327
<400> 5319

ttttttttt  tttttttgt  atgtaaggt  ctcttttat  taaaagatc  ttcacaaaa  60
accatatcc  tagactcac  ttctgtcat  gaactgaat  tgttaagtg  ttggaattc  120
attcttaca  agtcagctg  gcgcccagc  gtgtggatg  acgtgcctg  tctgtcttt  180
ccgcattgg  gatggatta  atcatctga  agcatcagc  ttgattaca  ccacgcaat  240
catgtctcc  attctgtgt  ctcatccca  ctggatacc  accaacagg  caccacagc  300
gcctagcta  tggccccag  tctttccca  aagccaagg  gtggctggc  ggaagctgc  360
ggctaacga  caagctgcg  acctcagcc  ttct  394



<210> 5320
<211> 647
<212> PRT
<213> Rattus norvegicus
<308> AAD34858
<400> 5320

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
  1               5                  10                  15
Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
             20                  25                  30
Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
         35                  40                  45
Cys Phe Arg Cys Cys Glu Cys Ser Val Ser Leu Ser His Gln Tyr Tyr 
     50                  55                  60
Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
 65                  70                  75                  80
Gly Glu Ser Cys His Gly Cys Ser Glu His Ile Thr Lys Gly Leu Val 
                 85                  90                  95
Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
             100                105                110
Ala Cys Gly Asn Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
         115                120                125
His Ser Lys Leu Tyr Cys Gly Gln Cys Tyr Tyr Gln Thr Val Val Thr 
     130                135                140
Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
 145                150                155                160
His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ala His Gly Lys Arg 
                 165                170                175
Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
             180                185                190
Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
         195                200                205
Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
     210                215                220
Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
 225                230                235                240
Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                 245                250                255
Asp Pro His Asp Ser Leu Gly His Gly Pro Val Ser Asp Pro Ser Pro 
             260                265                270
Leu Ser Ser Pro Val His Thr Pro Ser Gly Gln Ala Ala Ser Ser Ala 
         275                280                285
Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Thr Ser Pro Gly 
     290                295                300
Thr Ser Ser Leu Ala Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
 305                310                315                320
Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                 325                330                335
Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
             340                345                350
Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
         355                360                365
Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
     370                375                380
Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
 385                390                395                400
Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                 405                410                415
Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Asn Met Asp Ser Gln Tyr 
             420                425                430
Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
         435                440                445
Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
     450                455                460
Asn Cys Leu Val Arg Glu Asn Arg Asn Val Val Val Ala Asp Phe Gly 
 465                470                475                480
Leu Ala Arg Leu Met Ile Asp Glu Lys Asn Gln Ser Glu Asp Leu Arg 
                 485                490                495
Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
             500                505                510
Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
         515                520                525
Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
     530                535                540
Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
 545                550                555                560
Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                 565                570                575
Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
             580                585                590
Lys Arg Pro Ser Phe Val Lys Leu Glu Gln Trp Leu Glu Thr Leu Arg 
         595                600                605
Met His Leu Ser Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
     610                615                620
Glu Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Ser Leu Pro 
 625                630                635                640
Ala His Pro Glu Val Pro Asp 
                 645



<210> 5321
<211> 2477
<212> DNA
<213> Homo sapiens
<308> D26068
<400> 5321

gacggcaaa  ggcggactt  gacacctac  acgatcggg  ctacagcag  ttcggcggc  60
gcagagggt  ccgcggcag  gctggtggc  atggttccc  tagccagaa  gagttgccc  120
cagagcccc  ctacacagc  tacgtagga  atctacctt  caatacggt  cagggcgac  180
tagatgcta  ctttaagga  ctcagcata  ggagtgtac  gctagtcag  gacaaagac  240
cagataaat  taaaggatt  tgctatgta  aattcgatg  agtggattc  cttaaggaa  300
ccttgacat  cgatggtgc  ctgttgggc  atcggtcac  tcgtgtgga  attgcagaa  360
gcagaaaac  agataaagg  ggctttgga  tcagaaaag  tggaccaga  gacagaggc  420
tcagggatg  cttcttagg  ggcagggga  gtagtcgcc  aggcgaccg  cgaacaggc  480
cccccatgg  cagccgctt  agagatggc  ctcccctcc  tggatccaa  atggatttc  540
gagaaccca  agaagagga  agagcacag  gaccacgac  ccagcttaa  cctcgaaca  600
tcgcgacgc  cctcaatca  gtagccaat  ccaactctg  tatcttcgg  ggtgccagg  660
ctagagagg  agtcgttca  aaggagcaa  aatgagcct  cggttggga  ggaatgggg  720
gtggggggt  agagcagga  cacagcctg  tgagtcccc  ggcagccgt  ctgcagccg  780
cactcctgc  cctgccatt  gcctcctca  agcggaaac  cagcttgtg  gtgcatgtc  840
gctgttaac  agtggtttt  agtacattc  gggctttgc  gtatctatc  agtgcctgt  900
tgtgcgttt  tttctttct  ccgctgctt  cccattttc  ttctgtcct  tttctcctg  960
tccttgttt  cccagcagc  catggggtt  ctcggagga  cagaggtgg  cgccgtggg  1020
gggcgtttg  gctgcggtg  tgcgtcatt  ttcctttgc  ttctcttta  tttagacac  1080
ggcccaact  caggcgttt  ctttcattc  ctcagtgct  ctcttctga  ctgcatgtt  1140
agttctgta  tgctggggc  tccaacaaa  accagagtc  ctgacagag  gaacagcag  1200
gaccttgtt  gtattcagc  gtgatggat  tagagaatc  gaggcacct  gttttcaca  1260
ctaggataa  aatatctgc  gggtccttt  cattcctat  tagagggag  cctggctcc  1320
tgaccccct  ccgagtgga  tgtccaagc  gataggctc  cacgagaaa  agtgaggct  1380
aaagggggg  ctatggaag  gcggtaggg  gtccacgga  aagatgcag  gaatgcttg  1440
atgcattca  acgtgtgtg  gtcccagct  gttcactcc  ttcgccgtg  gtggtggag  1500
ctggcctct  tggctgggt  cagtgaatg  ccagcgggt  tcttttctg  tgggccaag  1560
cgctttggg  gtggagggg  tggtgctgg  gctgcactg  gctgactgc  gcgctgacg  1620
agcgtttcc  cccatccct  ttgcctgtg  gttgtgtgg  tctgttcct  gtataggca  1680
cataatgag  tactgtgct  cccacctcc  cttcagttc  gagccaaaa  gggtctaga  1740
tctggcttt  ctcatttcc  ttgataaat  gtactatgc  gagctgtca  gaaccttca  1800
atagcagta  aggactgca  ctgtctagg  ctgcggcca  atcttgggg  cacactgga  1860
tgttcccat  tgcagggtt  agcagttat  tgggagtgc  aggggttag  cttttgagc  1920
tgaacgcct  cgtgtgaac  gatgaaaaa  ccttcagta  ccaagtccc  gtctgtcct  1980
tggggagca  tttgggggc  gccggcagc  ggagcctgg  aaagaggcc  tcgccaggt  2040
atggcaggg  cagggtggc  tggggcacc  agcggaatg  gcttagtat  tggtcacca  2100
ccgtcatcc  gggcttttc  tactgtgtc  tgttacaag  cctcagcaa  ccacagaac  2160
ctctctcct  ccttccacc  gtcagcttc  ctgcttctg  gataagaac  atttgtgta  2220
caccaacac  taacttcag  aagacatgc  ttatgtggt  taatcaaac  cgatgcttt  2280
agatgacct  cttacatct  caatgtgga  aagataaag  acaaaacac  tgcatctaa  2340
ctgctgggc  atccagttg  cttttaaat  taagaatgg  attccaaac  cttaacaca  2400
tcagctata  gacagaaag  aaatctatg  atatggtat  ttgtgaatg  tcttttaaa  2460
aaaagaaaa  cttacgt  2477



<210> 5322
<211> 248
<212> PRT
<213> Homo sapiens
<308> Q15056
<400> 5322

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
  1               5                  10                  15
Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
             20                  25                  30
Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
         35                  40                  45
Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
     50                  55                  60
Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
 65                  70                  75                  80
Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                 85                  90                  95
Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
             100                105                110
Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
         115                120                125
Arg Lys Gly Gly Pro Asp Asp Arg Gly Met Gly Ser Ser Arg Glu Ser 
     130                135                140
Arg Gly Gly Trp Asp Ser Arg Asp Asp Phe Asn Ser Gly Phe Arg Asp 
 145                150                155                160
Asp Phe Leu Gly Gly Arg Gly Gly Ser Arg Pro Gly Asp Arg Arg Thr 
                 165                170                175
Gly Pro Pro Met Gly Ser Arg Phe Arg Asp Gly Pro Pro Leu Arg Gly 
             180                185                190
Ser Asn Met Asp Phe Arg Glu Pro Thr Glu Glu Glu Arg Ala Gln Arg 
         195                200                205
Pro Arg Leu Gln Leu Lys Pro Arg Thr Val Ala Thr Pro Leu Asn Gln 
     210                215                220
Val Ala Asn Pro Asn Ser Ala Ile Phe Gly Gly Ala Arg Pro Arg Glu 
 225                230                235                240
Glu Val Val Gln Lys Glu Gln Glu 
                 245



<210> 5323
<211> 472
<212> DNA
<213> Rattus norvegicus
<308> AA875348
<400> 5323

ttttttttt  tttttttca  tgcttccaa  aactttatt  ataacaggc  aagcctgga  60
acaacccaa  gaacaatgt  agattttat  aaatggaat  tactcagca  taaaaatga  120
tcaattatc  atgcataca  taacatgaa  aaagcagtt  aagtacaag  atgggaaca  180
aaacgaaca  ataatgttt  gcccattaa  tactgtttg  gaggagata  tagaaagac  240
caaagatac  tttgaaatg  aatataatg  aaatgtttt  tatcatagt  gtagagttc  300
ttacattat  tatacattt  acaaatcat  gtgtatact  aaattttta  ttttactta  360
ataaaatgt  catcaaatt  attaccaaa  actgatggt  gttgtatgg  caaaacagt  420
tgtgacaca  tgttgacca  ctacaactt  cacaacaag  ttttttttt  tt  472



<210> 5324
<211> 419
<212> DNA
<213> Rattus norvegicus
<308> AA875362
<400> 5324

ttttttttt  tttttttca  ttagtattt  aataatata  aaaagacaa  acaaaatcc  60
aacattcct  tttacaagt  cagatacat  tttttcccc  aagtgcaaa  tactctgtg  120
accacattg  tgctgtctg  tgttggctg  gatgctcgc  gtgtgggag  cggtagaag  180
cagatataa  tacagtatt  tgagatctt  ttcttttgc  ttaaaaaaa  agccatcca  240
gtgataatt  ttctctgaa  gttccaact  acatagaac  aagttttga  cttgtttgt  300
tcaggaagc  gatcgcaga  ctgggcttc  agtccttct  gctctcaaa  gattcctag  360
cgaacgaaa  aatggcaga  agacagagt  tgccagctt  gagacaggt  caatgtcaa  419



<210> 5325
<211> 549
<212> DNA
<213> Homo sapiens
<308> AA908851
<400> 5325

aactttttt  ttttttttt  ttttcattt  gtattttaa  aataataaa  aagacatac  60
aaatccaaa  atttctttt  acaattcag  tacatattt  tccccaagt  caaaatact  120
tatgaactg  atcatttgc  gtttattgt  gattgtata  gagatgctt  ctaaattgg  180
agcagtgga  ggcagatat  aatacaata  tttgaaatt  cttctgcat  taacaaaaa  240
cctcccaca  ggcgatgat  attctgaaa  ttgagttca  ctcacacag  agtataaag  300
tttcagttt  ttcaaactg  tacaacctg  ggtgtctaa  aaagctgat  acaactggg  360
gttctattc  ttctaatca  atatttcct  gtacaaata  tggcacaag  atagggtgt  420
ctacttttg  gacgggtca  atgtaaaaa  atccttgtg  tgttcgctc  cacttttat  480
gtgcttaag  aagaaacct  gagggttaa  attttctgc  tatgctcag  tatactttg  540
cttggtacc  549



<210> 5326
<211> 538
<212> DNA
<213> Rattus norvegicus
<308> AA875425
<400> 5326

tattttttt  tttttttca  tcaacaagt  tttattgag  gcctactat  tgccaggca  60
tgtcatgag  cgatgggaa  agatacagc  gtgaagaca  acaaagtac  tgctctcga  120
gagcttcca  tctaacgta  acgctagct  acattgcaa  agtgagtaa  atcgtacta  180
caaaagtaa  aaaagcacc  gaatgaaaa  agacctttt  acctaaact  ttaaaaaga  240
actacataa  attcaaaat  gtataatga  ttgtaacag  taaaataac  ttttacatg  300
tgttaaaac  tattttagc  atcatttaa  tcaactttc  tagaatatg  tacaaggtg  360
gatagaaga  cataaccca  attcacatg  aaatacctt  gatacttca  atcagtatt  420
cccagatga  ccattaacc  tttgtttta  agtactttc  taatggtaa  ttgccacta  480
cattcaaat  aaagtactt  ataattcct  cttaatata  attttatac  tgtcatgg  538



<210> 5327
<211> 494
<212> DNA
<213> Rattus norvegicus
<308> AA875428
<400> 5327

atttttttt  tttttttgc  cttctgtgt  taataagtc  catcttcag  tgctcctgg  60
gtggaatgt  agaccttga  tcttgtagt  atgtcagtg  gtgggcatg  ggctgtgaa  120
aacatcttt  tgccacaca  atgacatct  tggagtagg  acatgtgca  gaggagctc  180
atagtttca  ccacagtac  cctgctaca  agtccctgt  ggcaatggc  gccaagtgg  240
tatgtgaca  ctaacaaag  cagtggaca  ctgaggtag  tagtagccc  gcagagaca  300
gagtacaac  attagagga  gcagatcca  gaccacaat  ctcttagga  ccatagtgc  360
ctcaggatg  ggtgttttc  tggggacat  ggccaccca  ccccttggg  gagggtcca  420
aactatctg  cttgcagct  actcttact  atagtccta  gggctaaaa  gatgctggt  480
gactctcag  gcga  494



<210> 5328
<211> 2146
<212> DNA
<213> Homo sapiens
<308> NM_022171
<400> 5328

tactcccgg  gtcactcat  ccttaagca  gcagggtgg  gttaggtgc  cgtgcgcgg  60
tttaatact  ctccccgaa  tgccaactc  tcacgcacg  gaagtaggc  ccaccctgg  120
tgggtttac  cgtgcgcac  aacgggcct  gtcccggaa  accacacgc  tgcgtggtg  180
ggactacgg  gacagtacc  cgggtgggg  gagggccag  catggcgga  tcctggtct  240
ggcaggcct  gcaggctct  ccggccacg  tgctgggcg  gctgggcag  gagttcttg  300
gggagtggg  ggcgcagga  atgcgcgtg  ccctcttca  gctgctgct  ctgtggttg  360
tgttaagtc  cctgggcat  cagctggcg  gggggttct  cgggaatac  gtgaccggg  420
tgtatcacc  tccaggtct  ggtggtcag  atggatcca  gcctgatgg  tccacgcat  480
tcccttcgt  ggaaatggc  gcaaacgaa  ctctcaaaa  ccacagaga  taagggaag  540
cagcagagg  tctccaagg  catcactgg  tctgctggc  tctacactg  gttctgcta  600
tccccagac  tcagggaca  ctgccgggg  ttcagggtt  gtagcaggg  gtacccagt  660
cctacaggg  tgggcctct  ctgcctctt  agcctgctc  ctcacccag  cactgggca  720
gtgaagagt  tgcctgtac  cttatctgg  tgccttaag  agagagatt  tgttcttcc  780
ctctcaggg  tgataactc  ggaagcctc  gggttggga  gaccatcag  tcttttgtc  840
taggtttct  ttcctgtcc  tcttccatc  ccaagatgt  accccataa  aatttttcc  900
gagttggcc  ggcatggtg  ctcacgcct  taatcccaa  actttggga  gctgaggca  960
gcagatcac  aggtcagga  ttcgagacc  gcctgacca  catggtgaa  accccatct  1020
tactaaaaa  acaaaaatt  gccgggtgt  gtggcacac  ccagtaatc  cagctactc  1080
ggaggctga  gcaggagat  tgcttgaac  tgggaggca  aggttgcag  gagccaaga  1140
tgcgccgtt  tactccagc  tgggcaaca  agcaagacc  atctcaaaa  aaaaatttt  1200
ttcctgaga  gaagcctga  gttgaccag  tctggggtt  gtaaggcag  tctgttttc  1260
cctaggccc  gagttttct  aatctctgg  tttgctttg  tggcaagga  ccagggaat  1320
ctgacctga  ccagacctt  agctctatg  ttatttagc  ggccattca  gtataaggc  1380
gggtggtgt  cctgctggc  ctatccaga  ggaggcacc  aacacccac  tacctggcc  1440
aaccagact  ctcccgtga  ccaggcaaa  gaaattgtc  tctgccaac  gtcctactc  1500
tattcctct  agtccttct  gggggtaag  tgattacct  aaggacagc  gaacccctg  1560
ggtagcctc  tatccacca  tgcttaagt  cctatggga  tgtgggtct  caccttgtc  1620
cctcatagg  tggtaccaa  catttagtg  acagtggcc  catcatagc  tgcagcctc  1680
tcatttccc  tctggacct  gtacaaatg  acgtcacag  ctcagctcc  ccccactag  1740
atcttctct  ccttcaaga  ccaggcagc  ctgccatgt  acaataggc  aggggagtt  1800
ccaaagatg  gggtggcaa  tgcccctat  gaaacacca  tacctgaaa  cactgtagc  1860
ctggacctg  ctccttccc  cggggccat  cttctgttt  catctgctg  gccaccagc  1920
actttagtg  cccctgcct  cttccttcc  gttggatat  atacttcca  ctggctgcc  1980
ttgcttaag  catctttgt  gtagagggg  cctggaatt  cagctgtac  gaggatgat  2040
ttattcaca  cccctggcc  acccactaa  actactgca  agagtcagg  tctcacatt  2100
caccccagg  tcaactgag  atgtggctt  ttaaacacg  aagtgc  2146



<210> 5329
<211> 392
<212> DNA
<213> Rattus norvegicus
<308> AA875444
<400> 5329

ttttttttt  gaacattcc  ttgaaattt  gagaaactt  caactcttc  gtaatcact  60
ccgatgttt  ttgtacggg  ccgcgggcc  cttggttgt  ttcgagcat  ttcttaaaa  120
aaaagaaac  agagggaca  aacagtttt  aaccggaag  tttccgcag  ccgtgtaag  180
atgtttacc  gttggtttg  tttctgtgt  tgtgaaatg  atgtcatgt  taaatgcca  240
cctaaggca  cagcgtctc  taactgagt  actgcagtg  cttgatgct  tacatcatt  300
tagaattta  tgctatatg  ttttaatcc  tgaacctgt  attgtgacc  acgatgggg  360
acctttcag  gctaaagct  atcatgtgt  ta  392



<210> 5330
<211> 572
<212> PRT
<213> Rattus norvegicus
<308> Q62950
<400> 5330

Met Ser His Gln Gly Lys Lys Ser Ile Pro His Ile Thr Ser Asp Arg 
  1               5                  10                  15
Leu Leu Ile Arg Gly Gly Arg Ile Ile Asn Asp Asp Gln Ser Phe Tyr 
             20                  25                  30
Ala Asp Val Tyr Leu Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 
         35                  40                  45
Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala Asn Gly Arg Met 
     50                  55                  60
Val Ile Pro Gly Gly Ile Asp Val Asn Thr Tyr Leu Gln Lys Pro Ser 
 65                  70                  75                  80
Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Arg Ala Ala 
                 85                  90                  95
Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro 
             100                105                110
Gly Ser Ser Leu Leu Thr Ser Phe Glu Lys Trp His Glu Ala Ala Asp 
         115                120                125
Thr Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Thr Ser Trp 
     130                135                140
Tyr Asp Gly Val Arg Glu Glu Leu Glu Val Leu Val Gln Asp Lys Gly 
 145                150                155                160
Val Asn Ser Phe Gln Val Tyr Met Ala Tyr Lys Asp Leu Tyr Gln Met 
                 165                170                175
Ser Asp Ser Gln Leu Tyr Glu Ala Phe Thr Phe Leu Lys Gly Leu Gly 
             180                185                190
Ala Val Ile Leu Val His Ala Glu Asn Gly Asp Leu Ile Ala Gln Glu 
         195                200                205
Gln Lys Arg Ile Leu Glu Met Gly Ile Thr Gly Pro Glu Gly His Ala 
     210                215                220
Leu Ser Arg Pro Glu Glu Leu Glu Ala Glu Ala Val Phe Arg Ala Ile 
 225                230                235                240
Ala Ile Ala Gly Arg Ile Asn Cys Pro Val Tyr Ile Thr Lys Val Met 
                 245                250                255
Ser Lys Ser Ala Ala Asp Ile Ile Ala Leu Ala Arg Lys Lys Gly Pro 
             260                265                270
Leu Val Phe Gly Glu Pro Ile Ala Ala Ser Leu Gly Thr Asp Gly Thr 
         275                280                285
His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 
     290                295                300
Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Tyr Leu Thr Ser Leu 
 305                310                315                320
Leu Ala Cys Gly Asp Leu Gln Val Thr Gly Ser Gly His Cys Pro Tyr 
                 325                330                335
Ser Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro 
             340                345                350
Glu Gly Val Asn Gly Ile Glu Glu Arg Met Thr Val Val Trp Asp Lys 
         355                360                365
Ala Val Ala Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr 
     370                375                380
Ser Thr Asn Ala Ala Lys Ile Phe Asn Leu Tyr Pro Arg Lys Gly Arg 
 385                390                395                400
Ile Ala Val Gly Ser Asp Ala Asp Val Val Ile Trp Asp Pro Asp Lys 
                 405                410                415
Met Lys Thr Leu Thr Ala Lys Ser His Lys Ser Thr Val Glu Tyr Asn 
             420                425                430
Ile Phe Glu Gly Met Glu Cys His Gly Ser Pro Leu Val Val Ile Ser 
         435                440                445
Gln Gly Lys Ile Val Phe Glu Asp Gly Asn Ile Ser Val Ser Lys Gly 
     450                455                460
Met Gly Arg Phe Ile Pro Arg Lys Pro Phe Pro Glu His Leu Tyr Gln 
 465                470                475                480
Arg Val Arg Ile Arg Ser Lys Val Phe Gly Leu His Ser Val Ser Arg 
                 485                490                495
Gly Met Tyr Asp Gly Pro Val Tyr Glu Val Pro Ala Thr Pro Lys His 
             500                505                510
Ala Ala Pro Ala Pro Ser Ala Lys Ser Ser Pro Ser Lys His Gln Pro 
         515                520                525
Pro Pro Ile Arg Asn Leu His Gln Ser Asn Phe Ser Leu Ser Gly Ala 
     530                535                540
Gln Ile Asp Asp Asn Asn Pro Arg Arg Thr Gly His Arg Ile Val Ala 
 545                550                555                560
Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Gly 
                 565                570



<210> 5331
<211> 392
<212> DNA
<213> Rattus norvegicus
<308> AA875444
<400> 5331

ttttttttt  gaacattcc  ttgaaattt  gagaaactt  caactcttc  gtaatcact  60
ccgatgttt  ttgtacggg  ccgcgggcc  cttggttgt  ttcgagcat  ttcttaaaa  120
aaaagaaac  agagggaca  aacagtttt  aaccggaag  tttccgcag  ccgtgtaag  180
atgtttacc  gttggtttg  tttctgtgt  tgtgaaatg  atgtcatgt  taaatgcca  240
cctaaggca  cagcgtctc  taactgagt  actgcagtg  cttgatgct  tacatcatt  300
tagaattta  tgctatatg  ttttaatcc  tgaacctgt  attgtgacc  acgatgggg  360
acctttcag  gctaaagct  atcatgtgt  ta  392



<210> 5332
<211> 572
<212> PRT
<213> Rattus norvegicus
<308> Q62950
<400> 5332

Met Ser His Gln Gly Lys Lys Ser Ile Pro His Ile Thr Ser Asp Arg 
  1               5                  10                  15
Leu Leu Ile Arg Gly Gly Arg Ile Ile Asn Asp Asp Gln Ser Phe Tyr 
             20                  25                  30
Ala Asp Val Tyr Leu Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 
         35                  40                  45
Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala Asn Gly Arg Met 
     50                  55                  60
Val Ile Pro Gly Gly Ile Asp Val Asn Thr Tyr Leu Gln Lys Pro Ser 
 65                  70                  75                  80
Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Arg Ala Ala 
                 85                  90                  95
Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro 
             100                105                110
Gly Ser Ser Leu Leu Thr Ser Phe Glu Lys Trp His Glu Ala Ala Asp 
         115                120                125
Thr Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Thr Ser Trp 
     130                135                140
Tyr Asp Gly Val Arg Glu Glu Leu Glu Val Leu Val Gln Asp Lys Gly 
 145                150                155                160
Val Asn Ser Phe Gln Val Tyr Met Ala Tyr Lys Asp Leu Tyr Gln Met 
                 165                170                175
Ser Asp Ser Gln Leu Tyr Glu Ala Phe Thr Phe Leu Lys Gly Leu Gly 
             180                185                190
Ala Val Ile Leu Val His Ala Glu Asn Gly Asp Leu Ile Ala Gln Glu 
         195                200                205
Gln Lys Arg Ile Leu Glu Met Gly Ile Thr Gly Pro Glu Gly His Ala 
     210                215                220
Leu Ser Arg Pro Glu Glu Leu Glu Ala Glu Ala Val Phe Arg Ala Ile 
 225                230                235                240
Ala Ile Ala Gly Arg Ile Asn Cys Pro Val Tyr Ile Thr Lys Val Met 
                 245                250                255
Ser Lys Ser Ala Ala Asp Ile Ile Ala Leu Ala Arg Lys Lys Gly Pro 
             260                265                270
Leu Val Phe Gly Glu Pro Ile Ala Ala Ser Leu Gly Thr Asp Gly Thr 
         275                280                285
His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 
     290                295                300
Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Tyr Leu Thr Ser Leu 
 305                310                315                320
Leu Ala Cys Gly Asp Leu Gln Val Thr Gly Ser Gly His Cys Pro Tyr 
                 325                330                335
Ser Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro 
             340                345                350
Glu Gly Val Asn Gly Ile Glu Glu Arg Met Thr Val Val Trp Asp Lys 
         355                360                365
Ala Val Ala Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr 
     370                375                380
Ser Thr Asn Ala Ala Lys Ile Phe Asn Leu Tyr Pro Arg Lys Gly Arg 
 385                390                395                400
Ile Ala Val Gly Ser Asp Ala Asp Val Val Ile Trp Asp Pro Asp Lys 
                 405                410                415
Met Lys Thr Leu Thr Ala Lys Ser His Lys Ser Thr Val Glu Tyr Asn 
             420                425                430
Ile Phe Glu Gly Met Glu Cys His Gly Ser Pro Leu Val Val Ile Ser 
         435                440                445
Gln Gly Lys Ile Val Phe Glu Asp Gly Asn Ile Ser Val Ser Lys Gly 
     450                455                460
Met Gly Arg Phe Ile Pro Arg Lys Pro Phe Pro Glu His Leu Tyr Gln 
 465                470                475                480
Arg Val Arg Ile Arg Ser Lys Val Phe Gly Leu His Ser Val Ser Arg 
                 485                490                495
Gly Met Tyr Asp Gly Pro Val Tyr Glu Val Pro Ala Thr Pro Lys His 
             500                505                510
Ala Ala Pro Ala Pro Ser Ala Lys Ser Ser Pro Ser Lys His Gln Pro 
         515                520                525
Pro Pro Ile Arg Asn Leu His Gln Ser Asn Phe Ser Leu Ser Gly Ala 
     530                535                540
Gln Ile Asp Asp Asn Asn Pro Arg Arg Thr Gly His Arg Ile Val Ala 
 545                550                555                560
Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Gly 
                 565                570



<210> 5333
<211> 512
<212> DNA
<213> Rattus norvegicus
<308> AA875495
<400> 5333

ttttttttt  tttttttgt  taaaaaaga  ttattgaaa  ttatcaatg  caaacagac  60
taaaactca  agtttggct  ttctcaggg  cgggagaaa  atgagttac  gctgatctg  120
acaaatgag  cacagggta  gaaacagca  gtcacttct  aagcaatct  gaagggggg  180
gctgaaggc  cacgcactc  ctaggagaa  tctgcggcc  cttcagagt  ccaccaggt  240
agaaaatac  agcttgcat  ccttttccg  gctcctatg  atttgagaa  gaaaacaaa  300
agaacaaaa  cccagagga  acacagggc  cttccagag  ttagatttg  taaaaggtt  360
taagctgga  cgcccgagg  gtcctcctg  catttctgt  aaacaaatt  ctctaatat  420
ttacagaac  agatagaac  ggttggctt  tctgaagaa  ctgaaacac  aaggttcac  480
tctttccca  tttacgtgt  tcctaaacc  gc  512



<210> 5334
<211> 414
<212> DNA
<213> Homo sapiens
<308> BI495246
<400> 5334

gcacgagta  aacgctttg  tttacaaaa  atgatgaga  aattcttcc  catgtactt  60
tgtgcttag  acattttta  ggacctaag  gctggagac  ttgctgcat  tcggctggg  120
ttttttttt  atacacccg  gcacggaaa  actaacgca  aattgtatt  tcttaccta  180
tggaaatct  aaatgactg  aaattccta  tgaatgtac  ggtttgctt  cgtgtccct  240
ttctggttg  tttagaagt  acgtgtaat  tctgaaccc  tgtttcatc  gtataaaag  300
acatctgca  cagtttttc  cctgcccct  agaagagcc  aactttgag  tttatgtct  360
tttgtcatt  ataaatttc  ataaatctt  ttatacaaa  aaaaaaaaa  aaaa  414



<210> 5335
<211> 512
<212> DNA
<213> Rattus norvegicus
<308> AA875495
<400> 5335

ttttttttt  tttttttgt  taaaaaaga  ttattgaaa  ttatcaatg  caaacagac  60
taaaactca  agtttggct  ttctcaggg  cgggagaaa  atgagttac  gctgatctg  120
acaaatgag  cacagggta  gaaacagca  gtcacttct  aagcaatct  gaagggggg  180
gctgaaggc  cacgcactc  ctaggagaa  tctgcggcc  cttcagagt  ccaccaggt  240
agaaaatac  agcttgcat  ccttttccg  gctcctatg  atttgagaa  gaaaacaaa  300
agaacaaaa  cccagagga  acacagggc  cttccagag  ttagatttg  taaaaggtt  360
taagctgga  cgcccgagg  gtcctcctg  catttctgt  aaacaaatt  ctctaatat  420
ttacagaac  agatagaac  ggttggctt  tctgaagaa  ctgaaacac  aaggttcac  480
tctttccca  tttacgtgt  tcctaaacc  gc  512



<210> 5336
<211> 414
<212> DNA
<213> Homo sapiens
<308> BI495246
<400> 5336

gcacgagta  aacgctttg  tttacaaaa  atgatgaga  aattcttcc  catgtactt  60
tgtgcttag  acattttta  ggacctaag  gctggagac  ttgctgcat  tcggctggg  120
ttttttttt  atacacccg  gcacggaaa  actaacgca  aattgtatt  tcttaccta  180
tggaaatct  aaatgactg  aaattccta  tgaatgtac  ggtttgctt  cgtgtccct  240
ttctggttg  tttagaagt  acgtgtaat  tctgaaccc  tgtttcatc  gtataaaag  300
acatctgca  cagtttttc  cctgcccct  agaagagcc  aactttgag  tttatgtct  360
tttgtcatt  ataaatttc  ataaatctt  ttatacaaa  aaaaaaaaa  aaaa  414



<210> 5337
<211> 473
<212> DNA
<213> Rattus norvegicus
<308> AA875496
<400> 5337

ttttttttt  tttttttaa  cttatgaat  gtttattac  tttcaacaa  tgtattgtg  60
atcaataaa  caaaagcta  ggacaatga  ctcaagtta  cgattctta  gtttcaaaa  120
agaacagta  gaaagctat  aaagtgggg  ggtggactt  ggggtgtat  agcaatagg  180
atctaaagc  tcaaaacac  ggctaagaa  gtctaggac  caaggaaga  tccagcagc  240
ccctcagat  tctaattcc  gtcatttac  tttcactct  aaaagtatc  taaattttt  300
atatttatt  gttttttgt  ttttcaaga  agggtctca  atatagctc  gcctacccc  360
gaactcaca  tgaagtcca  gctgacctt  aactcacag  gaccctcta  cctctgcct  420
tgtcgtgct  gaattaaag  cacatgcac  actatgccc  gcataaata  tta  473



<210> 5338
<211> 338
<212> DNA
<213> Homo sapiens
<308> AA521144
<400> 5338

ttttttttt  ttttttttt  ttttgcaag  ttatgaata  tttattaca  ttcagtaag  60
gtattgtga  tcaataaag  aaaagttaa  gacaatgag  tcattacca  gccagttat  120
gattctctg  ttccaaaat  gaacagtac  ggaagggta  agagaaaat  ggatttttc  180
tgataaaaa  tttaagcat  ttaggaaca  agacctaaa  aaactataa  acacaacgg  240
aatttcagc  gctacttag  atgtttatt  atttacctt  ttttgccaa  tagaattag  300
tatttggtt  ttactctta  aaaaaaaag  attttcaa  338



<210> 5339
<211> 476
<212> DNA
<213> Rattus norvegicus
<308> AA875500
<400> 5339

ttttttttt  tttttttgc  aaaccgttt  gggctgatg  atgagcttt  acctttgca  60
tgagtgacg  tctctccgt  tgagcggca  cgtgggggg  agctgctcc  gtgtaaatg  120
ttactcaag  atgttccta  aggcgtgcg  tctctacta  gcctcgtgt  gcctacctt  180
gtgtggtgt  gtggagttc  agatcaagt  gagatactg  cgtagggtt  ttaatgaaa  240
tattgcacc  gttttttca  gttgtaaaa  taaagaatt  cgctctaca  tttgagaaa  300
tgtggccac  gctgtgacc  gcagcccgc  tgctgccca  gttgggccc  gcactttga  360
caggctttc  atgttgttt  gaaggttcc  acggtgaac  ttcttgttt  cagattttt  420
gtttgtttt  tgagaaaaa  aatgtttac  cttccatca  ttaaaaaaa  aaaatt  476



<210> 5340
<211> 5272
<212> DNA
<213> Homo sapiens
<308> XM_047123
<400> 5340

agttaacac  aacaaagga  gtggtgtgt  ggaatctgg  gcagcaaac  cccagagta  60
atcatgggg  agtggaaat  gcgcaaatt  tggaggaag  cgaagagga  ggggaaccc  120
tgcacaaaa  actggcact  atttaccca  cgttgagtg  aacaaactg  ctagcaatc  180
gcattccaa  gatagtgca  atggcaatg  taagacgtt  acaaatgga  ggaaatcta  240
tgaggaaga  gatcagggt  ctgccacat  tcagacaaa  gagcaaagc  gtgtgtggg  300
caaaacagg  ggtacagtg  agagcgatg  tagtacaga  agcactgga  gccttgagg  360
aaaaggaac  ggggaaagt  agagtagag  cagaagaaa  attgatcag  acacattac  420
ccaaagcat  gtaaacaga  ctgacttag  tccacgtgt  ctgtccaac  ctggttggg  480
acagactcc  attaagcag  atactgcct  ggatacaga  acatcacct  gaggggaac  540
aaagactga  aatgggaca  aggcctggg  aagctctgc  acacagact  ttaactcag  600
ggcatgtat  gataagact  gccctaatg  taatgatac  tcatctgta  cagggtggg  660
cgatcccaa  cctgctctg  ggtggggag  ttccaaagg  tcaaactgc  agggggggt  720
ggaagatga  tctgctgct  caggaatgg  caagagcaa  cagtggggg  attgcaaag  780
ggagaaggc  gcatggaat  actcgcaaa  gaataaaca  ggatggggt  atggacaaa  840
atcaagcca  gggtggtct  tttctgcca  tgataactg  ggagaaact  caaggaata  900
ccattgggg  gaggccaat  agaaatcca  ctcaggagg  agtgacagt  acaggtccg  960
ttccggttg  aacgaactt  gtaaaacta  ttctttcac  tggggaaac  acataaatc  1020
aaataattc  tcaggatgg  atgaatctt  taaacctac  ccttcccag  gatggggag  1080
ccctccaaa  tctaatcag  ctctaggtt  gggagattc  tcaaagcca  tcagctctc  1140
agactggaa  aagcaacaa  acattgttg  atcttgggg  atcccacca  ctacaggca  1200
acctcctgg  acaggctgg  tggggggac  tataccagc  ccagcaaaa  aagaagaac  1260
cacaggctg  gaggaacca  ccccagaat  tatacgtcg  aaaatggag  ttgatgatg  1320
aacttcagc  tggggagat  caagcaaat  caactacaa  aatgtgaac  tgtggaaca  1380
aaacgtccc  aatggcaac  gccgttcag  ccagcaagc  caggtacat  agctgctaa  1440
gcctgcaag  gccatctca  acaaagagg  aagcagtgg  tctggctgg  gtgagccct  1500
gggggagcc  tctactcca  ccacaactg  ggataatgg  acttcagca  ggggtaagc  1560
catagacag  ggtcccagc  ggggggaac  cattgctgc  gcatccagc  catccacgt  1620
gggctccag  tctgttggt  cacaagcat  aagcaaatc  gggccaaaa  ctatgcaag  1680
tggctggtg  ggtgatgat  tgccattgc  tggaaatcg  cccactggc  gggaagagg  1740
agaggatgt  gagattgga  tgtggaata  taattcatc  caagagctt  actcatctt  1800
aaattggcc  ccatataca  agaaaatgt  atcgaaggg  ctgagtggc  aaaaaagga  1860
aagggaaag  ggaatgatg  aaggtggaa  caaacaaga  gaagcgtgg  taaatccat  1920
tgttaaaca  ttttcaaac  tcagttttt  gagagactc  ccagaggaa  atgtacaaa  1980
caataagat  gacctttct  gaggaatgt  acaagacaa  cgaatggag  tagataaac  2040
tagcctaaa  attggtgat  acaatcgaa  ggtcgggaa  ggccctggt  ctcggcctc  2100
gatttccaa  gagtcttcc  tggagcgca  tccttattt  gataaggat  gcattgtag  2160
agatgaatc  caaaacatg  agtttatgt  cagtcaaag  atgaagctt  ccccttcaa  2220
tagtgcact  cctaaccag  cccttggct  catagcagg  ctgggtatg  aaaacttga  2280
ttctgttag  cagaatggc  atcccagta  gtttggtgt  ggaaacaca  cagcacaac  2340
ccggggcat  cagcagcct  cagcacaac  tcttagttc  tctcagcct  atctccgtg  2400
tcaagtgcc  cctccatta  tctcccctc  ggttccagt  tcattgctg  agtatgcac  2460
aaacaacgg  ggcctgaat  cactctttg  ccctcaaca  gtagccatg  tgaaccagc  2520
atcccagct  aaccagctt  ctcagatct  ccagttaca  cgattgtta  cgcagcagc  2580
aagggcgca  agtcagaga  gcgtgcctt  tgggaaccg  ccgcagcaa  accagcagg  2640
tcgacctct  agtgtgcag  agcaaatga  gcaacaatc  cgtcaactt  atccaaacc  2700
gttggtgaa  cagcagact  caccatctc  gcagcagcc  ctccatcag  cagccatga  2760
gtctttcct  gacaatgtc  tgccccaca  tacacctga  ctgcaaaaa  ggccatcac  2820
aataaatgc  ttcagcaac  tccctatag  cttgaactc  aacttgaat  taaatatgg  2880
tatgaacag  attaaagag  cacagtcaa  actaaggaa  tggacgaca  tggacagca  2940
ttctgtgaa  acatctttg  atcaaaact  cagcaaaca  ggtgctatt  caagtggtt  3000
caggctgga  gagtctcca  ttgttccct  tgactttat  aacagcagt  cttcaccag  3060
cagtcctcc  ggttcaata  gagatggct  gccacgtgc  aaatcgcct  acggctcta  3120
cagtgttaa  tggccacca  aatttcgtc  tggtgagcc  tggaaaggt  atccaaaca  3180
tgaccctga  actgaccct  acgtcactc  tggcagtgt  ataaacaat  tttcaatta  3240
tactgtgcg  gaagttgac  acctcaggg  caggaacag  gggtcatcc  catccttga  3300
caccacgct  ccttcaact  gtgcctggt  atccattcg  gcctccaac  acaacgttc  3360
cctcagcag  acagcacaa  gcacttcag  cagaaatag  gattccaaa  tgacatggt  3420
tcctggttc  gttacaaac  cctctctgg  tcatgagct  tggaaggtc  ctttgccac  3480
taaaaacat  actgctccg  cccgcccac  tccgggact  actggtcag  agccaccct  3540
gtctacgtg  gataattct  cccttcgta  aggtggagg  tggggaaat  ctgacgcca  3600
atatacccc  ggtaagagt  ccagctggg  tgagagcag  tcagggaga  taacaaatt  3660
gcttgttct  aaaaacctt  cacctcaga  cgatggctc  actctgcgc  ctctgtgca  3720
gcagcacgg  ccgctgatc  cattccacc  gaacctccc  cacggaaat  ctctggtcc  3780
ctacagttc  aaagaagag  tagtgaagg  acaaaagtc  ctgcacatg  gtgtactgg  3840
gaacactac  attcttgct  agtttgcca  tgaagagga  atcagtcgt  tctttgcac  3900
aagccagtc  ctgacccct  ctcccggct  gcagtctct  gggtccagc  agagccggc  3960
gggctccct  gactgttcc  actcattct  cagccggac  gatctcaat  actggaatg  4020
tgctgggct  tcgggaact  actgtggag  ccttcacgg  acttcactc  gggggaccc  4080
gcattattc  acaagcctg  ggggtcccc  aagcagcag  gacccccga  gaattagca  4140
cccatctcc  attaacgct  ttctttctg  tgaccacct  ggtgggggt  gagagtcca  4200
gtaacagtg  agatgcaga  tcaccgacc  ggacctcag  cgcgaggga  aggagcact  4260
agtggggct  gccgcctgc  gccaggggc  gcctgtggg  acagctatt  tctgcacat  4320
ttccacttt  ttttcccca  aacatatca  tttgaatac  tgaatcatg  aggccaata  4380
tataatgtg  aaaggtatc  actctattt  cactcccaa  tagcgccat  catgctaaa  4440
cgtagagaa  gagctcgct  gtgtctatt  atcatgttt  gcctttgga  tcttttttt  4500
tttttcctt  tattcctcc  caacccccc  ccccgcccc  ttttttctc  cttgcaaaa  4560
cattttttg  gctgataac  tatgagctt  tccctttgc  ctgaatgat  ttctctccg  4620
ctcatcggc  gtatggggg  cagctgtcc  agtgtcaat  tttactcaa  ggtgttctt  4680
ggaggcgtg  gctctctac  atgccttga  gttgcctac  ttattgtgg  atcgtggag  4740
ttaaaagat  aagttagga  gctgactta  gattattaa  gaaagtgtt  caccagttt  4800
ttcatgttg  aaaactaaa  aatttcgct  tgcagtttg  aaaactgtg  ccacagctg  4860
gacttgcag  ccacctgcc  cccaggacg  gccctgcac  ttgaatagg  tttccattt  4920
gttttggag  ttctcactt  gaaccttct  gtttacaga  ttttttgtt  gttttttga  4980
aaaaaaaaa  gtttactct  ccatcattt  aaaaaaatg  aaaagacaa  aaaaaaatg  5040
aggatgatt  aaaagatgc  ttctatctc  gggaaaaag  agcagcatt  ggccatgtt  5100
ttttgtttt  ctattcctg  cccaaatca  agagcatgg  tctcaggaa  accagttcc  5160
cagtttaaa  aaaaaaaaa  aaattcctt  tagtttctt  gaggaaaaa  agaaaaacc  5220
caactttta  cactgatac  acatattgc  ctgttaaag  attttctct  cc  5272



<210> 5341
<211> 1152
<212> PRT
<213> Homo sapiens
<308> XP_047123
<400> 5341

Met Val Lys Ser Asn Gln Trp Gly Asn Cys Lys Glu Glu Lys Ala Ala 
  1               5                  10                  15
Trp Asn Asp Ser Gln Lys Asn Lys Gln Gly Trp Gly Asp Gly Gln Lys 
             20                  25                  30
Ser Ser Gln Gly Trp Ser Val Ser Ala Ser Asp Asn Trp Gly Glu Thr 
         35                  40                  45
Ser Arg Asn Asn His Trp Gly Glu Ala Asn Lys Lys Ser Ser Ser Gly 
     50                  55                  60
Gly Ser Asp Ser Asp Arg Ser Val Ser Gly Trp Asn Glu Leu Gly Lys 
 65                  70                  75                  80
Thr Ser Ser Phe Thr Trp Gly Asn Asn Ile Asn Pro Asn Asn Ser Ser 
                 85                  90                  95
Gly Trp Asp Glu Ser Ser Lys Pro Thr Pro Ser Gln Gly Trp Gly Asp 
             100                105                110
Pro Pro Lys Ser Asn Gln Ser Leu Gly Trp Gly Asp Ser Ser Lys Pro 
         115                120                125
Val Ser Ser Pro Asp Trp Asn Lys Gln Gln Asp Ile Val Gly Ser Trp 
     130                135                140
Gly Ile Pro Pro Ala Thr Gly Lys Pro Pro Gly Thr Gly Trp Leu Gly 
 145                150                155                160
Gly Pro Ile Pro Ala Pro Ala Lys Glu Glu Glu Pro Thr Gly Trp Glu 
                 165                170                175
Glu Pro Ser Pro Glu Ser Ile Arg Arg Lys Met Glu Ile Asp Asp Gly 
             180                185                190
Thr Ser Ala Trp Gly Asp Pro Ser Lys Tyr Asn Tyr Lys Asn Val Asn 
         195                200                205
Met Trp Asn Lys Asn Val Pro Asn Gly Asn Ser Arg Ser Asp Gln Gln 
     210                215                220
Ala Gln Val His Gln Leu Leu Thr Pro Ala Ser Ala Ile Ser Asn Lys 
 225                230                235                240
Glu Ala Ser Ser Gly Ser Gly Trp Gly Glu Pro Trp Gly Glu Pro Ser 
                 245                250                255
Thr Pro Ala Thr Thr Val Asp Asn Gly Thr Ser Ala Trp Gly Lys Pro 
             260                265                270
Ile Asp Ser Gly Pro Ser Trp Gly Glu Pro Ile Ala Ala Ala Ser Ser 
         275                280                285
Thr Ser Thr Trp Gly Ser Ser Ser Val Gly Pro Gln Ala Leu Ser Lys 
     290                295                300
Ser Gly Pro Lys Ser Met Gln Asp Gly Trp Cys Gly Asp Asp Met Pro 
 305                310                315                320
Leu Pro Gly Asn Arg Pro Thr Gly Trp Glu Glu Glu Glu Asp Val Glu 
                 325                330                335
Ile Gly Met Trp Asn Ser Asn Ser Ser Gln Glu Leu Asn Ser Ser Leu 
             340                345                350
Asn Trp Pro Pro Tyr Thr Lys Lys Met Ser Ser Lys Gly Leu Ser Gly 
         355                360                365
Lys Lys Arg Arg Arg Glu Arg Gly Met Met Lys Gly Gly Asn Lys Gln 
     370                375                380
Glu Glu Ala Trp Ile Asn Pro Phe Val Lys Gln Phe Ser Asn Ile Ser 
 385                390                395                400
Phe Ser Arg Asp Ser Pro Glu Glu Asn Val Gln Ser Asn Lys Met Asp 
                 405                410                415
Leu Ser Gly Gly Met Leu Gln Asp Lys Arg Met Glu Ile Asp Lys His 
             420                425                430
Ser Leu Asn Ile Gly Asp Tyr Asn Arg Thr Val Gly Lys Gly Pro Gly 
         435                440                445
Ser Arg Pro Gln Ile Ser Lys Glu Ser Ser Met Glu Arg Asn Pro Tyr 
     450                455                460
Phe Asp Lys Asp Gly Ile Val Ala Asp Glu Ser Gln Asn Met Gln Phe 
 465                470                475                480
Met Ser Ser Gln Ser Met Lys Leu Pro Pro Ser Asn Ser Ala Leu Pro 
                 485                490                495
Asn Gln Ala Leu Gly Ser Ile Ala Gly Leu Gly Met Gln Asn Leu Asn 
             500                505                510
Ser Val Arg Gln Asn Gly Asn Pro Ser Met Phe Gly Val Gly Asn Thr 
         515                520                525
Ala Ala Gln Pro Arg Gly Met Gln Gln Pro Pro Ala Gln Pro Leu Ser 
     530                535                540
Ser Ser Gln Pro Asn Leu Arg Ala Gln Val Pro Pro Pro Leu Leu Ser 
 545                550                555                560
Pro Gln Val Pro Val Ser Leu Leu Lys Tyr Ala Pro Asn Asn Gly Gly 
                 565                570                575
Leu Asn Pro Leu Phe Gly Pro Gln Gln Val Ala Met Leu Asn Gln Leu 
             580                585                590
Ser Gln Leu Asn Gln Leu Ser Gln Ile Ser Gln Leu Gln Arg Leu Leu 
         595                600                605
Ala Gln Gln Gln Arg Ala Gln Ser Gln Arg Ser Val Pro Ser Gly Asn 
     610                615                620
Arg Pro Gln Gln Asp Gln Gln Gly Arg Pro Leu Ser Val Gln Gln Gln 
 625                630                635                640
Met Met Gln Gln Ser Arg Gln Leu Asp Pro Asn Leu Leu Val Lys Gln 
                 645                650                655
Gln Thr Pro Pro Ser Gln Gln Gln Pro Leu His Gln Pro Ala Met Lys 
             660                665                670
Ser Phe Leu Asp Asn Val Met Pro His Thr Thr Pro Glu Leu Gln Lys 
         675                680                685
Gly Pro Ser Pro Ile Asn Ala Phe Ser Asn Phe Pro Ile Gly Leu Asn 
     690                695                700
Ser Asn Leu Asn Val Asn Met Asp Met Asn Ser Ile Lys Glu Pro Gln 
 705                710                715                720
Ser Arg Leu Arg Lys Trp Thr Thr Val Asp Ser Ile Ser Val Asn Thr 
                 725                730                735
Ser Leu Asp Gln Asn Ser Ser Lys His Gly Ala Ile Ser Ser Gly Phe 
             740                745                750
Arg Leu Glu Glu Ser Pro Phe Val Pro Tyr Asp Phe Met Asn Ser Ser 
         755                760                765
Thr Ser Pro Ala Ser Pro Pro Gly Ser Ile Gly Asp Gly Trp Pro Arg 
     770                775                780
Ala Lys Ser Pro Asn Gly Ser Ser Ser Val Asn Trp Pro Pro Glu Phe 
 785                790                795                800
Arg Pro Gly Glu Pro Trp Lys Gly Tyr Pro Asn Ile Asp Pro Glu Thr 
                 805                810                815
Asp Pro Tyr Val Thr Pro Gly Ser Val Ile Asn Asn Leu Ser Ile Asn 
             820                825                830
Thr Val Arg Glu Val Asp His Leu Arg Asp Arg Asn Ser Gly Ser Ser 
         835                840                845
Ser Ser Leu Asn Thr Thr Leu Pro Ser Thr Ser Ala Trp Ser Ser Ile 
     850                855                860
Arg Ala Ser Asn Tyr Asn Val Pro Leu Ser Ser Thr Ala Gln Ser Thr 
 865                870                875                880
Ser Ala Arg Asn Ser Asp Ser Lys Leu Thr Trp Ser Pro Gly Ser Val 
                 885                890                895
Thr Asn Thr Ser Leu Ala His Glu Leu Trp Lys Val Pro Leu Pro Pro 
             900                905                910
Lys Asn Ile Thr Ala Pro Ser Arg Pro Pro Pro Gly Leu Thr Gly Gln 
         915                920                925
Lys Pro Pro Leu Ser Thr Trp Asp Asn Ser Pro Leu Arg Ile Gly Gly 
     930                935                940
Gly Trp Gly Asn Ser Asp Ala Arg Tyr Thr Pro Gly Lys Ser Ser Ser 
 945                950                955                960
Trp Gly Glu Ser Ser Ser Gly Arg Ile Thr Asn Trp Leu Val Leu Lys 
                 965                970                975
Asn Leu Thr Pro Gln Ile Asp Gly Ser Thr Leu Arg Thr Leu Cys Met 
             980                985                990
Gln His Gly Pro Leu Ile Thr Phe His Leu Asn Leu Pro His Gly Asn 
         995                1000                1005
Ala Leu Val Arg Tyr Ser Ser Lys Glu Glu Val Val Lys Ala Gln Lys 
     1010                1015                1020
Ser Leu His Met Cys Val Leu Gly Asn Thr Thr Ile Leu Ala Glu Phe 
 1025                1030                1035                1040
Ala Ser Glu Glu Glu Ile Ser Arg Phe Phe Ala Gln Ser Gln Ser Leu 
                 1045                1050                1055
Thr Pro Ser Pro Gly Trp Gln Ser Leu Gly Ser Ser Gln Ser Arg Leu 
             1060                1065                1070
Gly Ser Leu Asp Cys Ser His Ser Phe Ser Ser Arg Thr Asp Leu Asn 
         1075                1080                1085
His Trp Asn Gly Ala Gly Leu Ser Gly Thr Asn Cys Gly Asp Leu His 
     1090                1095                1100
Gly Thr Ser Leu Trp Gly Thr Pro His Tyr Ser Thr Ser Leu Trp Gly 
 1105                1110                1115                1120
Pro Pro Ser Ser Ser Asp Pro Arg Gly Ile Ser Ser Pro Ser Pro Ile 
                 1125                1130                1135
Asn Ala Phe Leu Ser Val Asp His Leu Gly Gly Gly Gly Glu Ser Met 
             1140                1145                1150



<210> 5342
<211> 529
<212> DNA
<213> Rattus norvegicus
<308> AA875506
<400> 5342

ttttttttt  ttttttaaa  aaaaaaaaa  aaacttgga  ttttcataa  tcaggggat  60
ccctgaaaa  attacctgc  ggtggaata  ttcatggac  aaatttttt  tccccttcc  120
aattcagtt  atcaccact  aagaacaaa  ataaactgg  ctcggtccc  gctgctgtg  180
ttgggtgga  attttgtcc  cttcccatg  tgctctccc  acattgtac  ctcttgggg  240
ttatatctc  tgttcttct  cagagaata  aaattgtag  tcatcacgg  aggatggga  300
gggaaaggt  gggagggcc  agtccgttc  gtacactgt  ctgctggct  gccacttca  360
ctcttttct  caggactgc  tccatggct  attccggct  tggtggagg  gggtctgtc  420
tagatacat  aaggtgtta  aagtctacc  aacttgcag  cagatccaa  agctttttt  480
ctgaacgaa  catgtctta  taacctaat  ctaaaagac  aattttagt  529



<210> 5343
<211> 393
<212> DNA
<213> Rattus norvegicus
<308> AA875511
<400> 5343

ttttttttt  tttttttgc  attcacact  gattttatt  catgacact  atttgctga  60
accccctgt  tcctgggca  ggaagggca  tgggtcgcc  ggtagaagc  gggctgcct  120
cccaggagg  ctgggattc  ctcttctca  ggaagcact  gccaagcct  agcattccc  180
gccctgacc  ctaaccttc  agttcattt  aaaattgag  aaaagtaaa  taaaatgaa  240
aaaaaataa  aacaaaccc  tgagttgtt  aaaaccaaa  taaaaatcc  ctttggtgt  300
agaaggtcc  attcctaaa  gccagcagg  tagggcagg  acaagcctg  cttgggcta  360
cattcagtc  tcaggctcc  catcagact  ctt  393



<210> 5344
<211> 887
<212> DNA
<213> Homo sapiens
<308> BF980184
<400> 5344

tctgcgcag  aggtaggca  tagggccca  aaaaaaggg  ggccagcct  ccaggagga  60
tggggcctg  tctgctggg  tcactgctg  ccaggcctc  gccttcctt  cagccccac  120
ctctcccct  cagtttgtt  aaaagttga  ctgcaaaaa  taaataaaa  taaaaacaa  180
cccctgagc  gttaaaaac  aaattaaaa  cccccctcc  tgtcaacag  tcctaaagc  240
agtgtggcg  gacaggcag  cggggcagg  ggggcaggc  gctggtgga  ctcagctgg  300
gcttgagtc  tcgggctca  cgtcagact  ctcctcctc  ttctcaggg  ccaggtggc  360
ctgggtgcc  ggccgcttc  ggatggcgc  gtacttgag  gctgtggac  ctgcctgca  420
gaccacctc  accaggctg  agatggtga  gacctgctg  gctggctcc  gctccatgt  480
ctcaggctc  cagaccagc  tgagttccg  cttcttgcc  accttctgg  agtggtggg  540
ccgcagggc  agtgcgttg  agtagatgc  cttctgcac  ccgtagcgc  gcaccagca  600
gtcgaaggc  tgcttcagg  tgcccatca  catggcttc  gactccagg  ggccactct  660
cttgaccag  acagcaaag  agagactgg  actgagctc  tgcacgcgc  tggacgcca  720
gcggcggtc  ttacggtgg  ccgcctgtt  ctgcaggat  tccggcgcc  gtctagtcg  780
tcctatgct  acgccgcag  aggnggctg  gcaccagga  ttcggcaaa  cgcggatgg  840
caggtgagt  tttgtccgc  ccctgacgc  tatgccgaa  ggcggtc  887



<210> 5345
<211> 519
<212> DNA
<213> Rattus norvegicus
<308> AA875552
<400> 5345

ttttttttt  tttttttaa  gtgtgccag  tgccacttt  attgagtcc  caccacagt  60
aggaagggt  gaagacagt  attgcttcc  ggctaagcc  catcggccc  gaggtaacc  120
acctcgctc  ccacagtag  aacatgcct  ccttcccct  agaatccca  gcctgagcc  180
acacaggga  ggatgtgca  agaaaaata  gagaagctc  tcaagggag  caggggcat  240
tctgaaatt  ttccagtgc  aagactagt  gacctggag  tgtccctcc  aatggcaat  300
ataaacccc  atcattccc  gctgaggcc  agcccttcc  cagggagcc  gagaccagg  360
ttcatgccc  agggctcct  cctgcagtg  tcccaggaa  gatcagcag  ctgcccagc  420
atggagaga  cccgctgag  agatgcgtc  tcctctttg  tggccccta  tacggcagg  480
gtacagcca  aaaggacca  gcagtacag  tgtggctgt  519



<210> 5346
<211> 471
<212> DNA
<213> Rattus norvegicus
<308> AA875563
<400> 5346

cggccgcac  aggacaacc  gagcttcca  tacgatcat  aggccttcc  aggcaagga  60
gattccaag  ccttcgatc  gctaagccc  gacgagagc  aggagaggc  ggggaaaat  120
gttgatcga  tcgacagtg  tggagacgg  cttgttact  ctgaggagc  gaaagtttg  180
atcaaacgg  tacagaaaa  atacatcta  gataatgtg  ctaaagtct  gaaggatta  240
gatagggac  aagacgaaa  gatctcctg  gaagaatac  agcaggcca  ctatggcta  300
tacctgggt  agacaccac  gcagagatg  cacagtggg  agcaaggtc  caggaggct  360
atcatggct  cctccttca  ccaaatgtc  caaccttca  gtgaaacct  ttgtgtaac  420
tcctcctcc  cctactaag  atgtaccaa  ttgcttcct  tgactgaca  a  471



<210> 5347
<211> 325
<212> PRT
<213> Rattus norvegicus
<308> NP_033063
<400> 5347

Met Ala Arg Gly Gly Arg Leu Gly Leu Ala Leu Gly Leu Leu Leu Ala 
  1               5                  10                  15
Leu Val Leu Ala Leu Arg Ala Lys Pro Thr Val Arg Lys Glu Arg Val 
             20                  25                  30
Val Arg Pro Asp Ser Glu Leu Gly Glu Arg Pro Pro Glu Asp Asn Gln 
         35                  40                  45
Ser Phe Gln Tyr Asp His Glu Ala Phe Leu Gly Lys Glu Asp Ser Lys 
     50                  55                  60
Thr Phe Asp Gln Leu Ser Pro Asp Glu Ser Lys Glu Arg Leu Gly Lys 
 65                  70                  75                  80
Ile Val Asp Arg Ile Asp Ser Asp Gly Asp Gly Leu Val Thr Thr Glu 
                 85                  90                  95
Glu Leu Lys Leu Trp Ile Lys Arg Val Gln Lys Arg Tyr Ile Tyr Asp 
             100                105                110
Asn Val Ala Lys Val Trp Lys Asp Tyr Asp Arg Asp Lys Asp Glu Lys 
         115                120                125
Ile Ser Trp Glu Glu Tyr Lys Gln Ala Thr Tyr Gly Tyr Tyr Leu Gly 
     130                135                140
Asn Pro Ala Glu Phe His Asp Ser Ser Asp His His Thr Phe Lys Lys 
 145                150                155                160
Met Leu Pro Arg Asp Glu Arg Arg Phe Lys Ala Ser Asp Leu Asp Gly 
                 165                170                175
Asp Leu Thr Ala Thr Arg Glu Glu Phe Thr Ala Phe Leu His Pro Glu 
             180                185                190
Glu Phe Glu His Met Lys Glu Ile Val Val Leu Glu Thr Leu Glu Asp 
         195                200                205
Ile Asp Lys Asn Gly Asp Gly Phe Val Asp Gln Asp Glu Tyr Ile Ala 
     210                215                220
Asp Met Phe Ser His Glu Asp Asn Gly Pro Glu Pro Asp Trp Val Leu 
 225                230                235                240
Ser Glu Arg Glu Gln Phe Asn Asp Phe Arg Asp Leu Asn Lys Asp Gly 
                 245                250                255
Lys Leu Asp Lys Asp Glu Ile Arg His Trp Ile Leu Pro Gln Asp Tyr 
             260                265                270
Asp His Ala Gln Ala Glu Ala Arg His Leu Val Tyr Glu Ser Asp Lys 
         275                280                285
Asn Lys Asp Glu Met Leu Thr Lys Glu Glu Ile Leu Asp Asn Trp Asn 
     290                295                300
Met Phe Val Gly Ser Gln Ala Thr Asn Tyr Gly Glu Asp Leu Thr Lys 
 305                310                315                320
Asn His Asp Glu Leu 
                 325



<210> 5348
<211> 289
<212> DNA
<213> Homo sapiens
<308> BI826212
<400> 5348

ctctccttg  tctcgtccg  ggtgagctc  tcgaagttc  tggagtcct  cttgcccag  60
aaggcctcg  ggtcgtact  gaagctctg  ttgtcctca  ggggccgct  gcccagctc  120
gagtcgggc  gcaccacgc  ctctttgcg  accgtgggc  tggcccgca  aacccgcgg  180
gccagcacc  gcgccagca  cagccccag  gctaacccc  ggcggccac  gcgcgccat  240
gtcccgagg  gagggcggc  gggagggag  cgctgagcg  gcgacaaca  289



<210> 5349
<211> 426
<212> DNA
<213> Rattus norvegicus
<308> AA875598
<400> 5349

ttatttttt  tttatttga  aagcagcaa  atcatgttt  tcattttaa  gtagataca  60
ttattaggt  atctgtcat  ttacaatat  taagttttt  gtttatgtc  tttaagata  120
attttaaaa  aaaaaaaaa  cacatcaac  gcaaacgtg  aggggagaa  gcatggtac  180
cagccgaat  ccacatctc  gcaatactt  actcattct  ttaataaag  tttaagaaa  240
gtcataatg  catgagctt  aatatctct  ggcattttc  ctgacgctc  tgacgtggc  300
ctggtgatg  tgtaaacag  agaaaaaca  gggctgcca  acgaccaaa  tatggaggc  360
caggcctgc  ttctcccac  ggagctcac  aaatgggga  ggcaatgac  tcacacccg  420
accatg  426



<210> 5350
<211> 2406
<212> DNA
<213> Homo sapiens
<308> U58088
<400> 5350

gaattcggc  cgaggacta  atggactgc  tatataggt  tctcaacac  cagtttatt  60
aaaagaata  attaacaga  gcggacctt  agtatggct  tggtggtgt  gatatgaat  120
aaccactta  ggaaatagg  gagctagca  tggatatgt  gaggaaatt  atggttgaa  180
cacttcagg  catccttat  cgaatgctg  tccgagaaa  caaaaatga  cgtggtgga  240
aagacccaa  ccagaaagt  atccatggg  ttattaact  ctttgttca  gttgaacag  300
ataagaaaa  attcccctt  aagttttat  aggaaattt  tgagtctcc  tttctgact  360
aaacaggag  gtattacaa  caagaagct  caaatttat  acaagaatc  aactgctca  420
agtatatgg  aaaggttct  ggtagatta  aagatgaag  aattcgatg  cgaaaatac  480
tacatccaa  ttcatatac  aaggtgatt  atgaatgtc  acaacgaat  gtagcagac  540
acttacagt  tttacatgc  gaatgtcat  atataattc  acaagagaa  aaaaatgac  600
tggcaaata  gtacgtctt  ctccgtgct  tgtccactg  tttacctca  atgattcag  660
agctgcaaa  ccacatcca  gatgagggc  ttcgagcaa  cagcaacct  actcaggaa  720
acatgccaa  actatttgt  gagtcagtt  tggaagtgc  tggtaaatt  gttcagctt  780
tcaacactg  tttgaatgg  gatcagcat  ttatgagtg  gttggataa  gcccttaca  840
cagttgtaa  ttacagaga  cctaagtct  tttgcaaag  acctgaact  cttgctaag  900
actgtgaca  cttactgaa  aagtcagcg  aagggatga  agagaatga  gtggaagac  960
ggctcacga  cttcatcac  gtgttcaaa  acattgatg  caaggacgt  tttcaaaag  1020
tctacgcaa  aatgctggc  aaacgttta  ttcatgggt  atccatgtc  atggactct  1080
aagaagcca  gatcaacaa  ttaaagcaa  cctgtggtt  tgagtttac  agcaagcta  1140
atcggatgt  tacagatat  agtgtcagc  ctgatctca  caataagtt  aacaatttt  1200
tcaaaaacc  agacacagt  atagatttg  gaattagtt  tcaaatata  gttctacag  1260
ctggtgcgt  gcctcttac  caggctcct  catctacgt  tgcaattcc  caggaatta  1320
aaaaaagtg  acagatgtt  gaattattt  atagccaac  tttcagtgg  aggaaactt  1380
catggttac  ttatctgtg  acaggtgaa  ttaaaatga  ctatttggg  aaaccatat  1440
tagccatgg  tacaacata  caaatggca  ttcttcttg  ctttaacaa  agtgaaact  1500
tcagttata  agagcttca  gacagcact  agatgaatg  aaaggaact  acaaaaaca  1560
tcaaatcat  acttgatgt  aaaatgatt  accatgatt  agaaaagga  gatattgat  1620
cagaatctt  attttcatt  aatatgaac  ttagcagta  aagaacaaa  tttaaaatt  1680
ctacatcaa  gcagaaaga  acaccacaa  aaatggagc  gactagaag  gcagttgat  1740
aggaccgga  aatgtatct  catgctgct  tagttcgta  catgaaagc  cgaaaagtg  1800
ttcggcaca  tgcccttat  caagaggtg  ttagccagt  aagagctag  tttaatccc  1860
gtatcagca  gattaagaa  tgtattgaa  ttctgatag  caaacaata  atagaacgc  1920
gccaggcgt  ggcagatga  tacagctac  tcgcgtgat  tcgctctcc  ccagcgtgg  1980
gtgagaaga  cattgccat  accatttgg  gtgttcctg  gggaaaaag  aggactgtg  2040
ctccataat  tggtcattt  gcagcccct  ttttctgct  tttacaaca  caccagtgc  2100
acgtcatga  cgtcaaaga  aatgcctag  gatatttca  gctcatgac  ttatgacat  2160
tcttaaaac  ttattaaaa  aatgagtga  gtattgctg  aaagtggaa  atcggttgg  2220
taccatgct  tttctcccc  tcacgtttg  agttgatgt  tcttttttt  tttttttaa  2280
gtatcttaa  ggacataaa  tttaaaaac  taaatattg  aatatgaca  ataacctaa  2340
aattgtatc  acattaaaa  gacaaacat  atactgctg  ttgtcaaat  aaaaaaaaa  2400
aaaaaa  2406



<210> 5351
<211> 745
<212> PRT
<213> Homo sapiens
<308> Q13617
<400> 5351

Met Ser Leu Lys Pro Arg Val Val Asp Phe Asp Glu Thr Trp Asn Lys 
  1               5                  10                  15
Leu Leu Thr Thr Ile Lys Ala Val Val Met Leu Glu Tyr Val Glu Arg 
             20                  25                  30
Ala Thr Trp Asn Asp Arg Phe Ser Asp Ile Tyr Ala Leu Cys Val Ala 
         35                  40                  45
Tyr Pro Glu Pro Leu Gly Glu Arg Leu Tyr Thr Glu Thr Lys Ile Phe 
     50                  55                  60
Leu Glu Asn His Val Arg His Leu His Lys Arg Val Leu Glu Ser Glu 
 65                  70                  75                  80
Glu Gln Val Leu Val Met Tyr His Arg Tyr Trp Glu Glu Tyr Ser Lys 
                 85                  90                  95
Gly Ala Asp Tyr Met Asp Cys Leu Tyr Arg Tyr Leu Asn Thr Gln Phe 
             100                105                110
Ile Lys Lys Asn Lys Leu Thr Glu Ala Asp Leu Gln Tyr Gly Tyr Gly 
         115                120                125
Gly Val Asp Met Asn Glu Pro Leu Met Glu Ile Gly Glu Leu Ala Leu 
     130                135                140
Asp Met Trp Arg Lys Leu Met Val Glu Pro Leu Gln Ala Ile Leu Ile 
 145                150                155                160
Arg Met Leu Leu Arg Glu Ile Lys Asn Asp Arg Gly Gly Glu Asp Pro 
                 165                170                175
Asn Gln Lys Val Ile His Gly Val Ile Asn Ser Phe Val His Val Glu 
             180                185                190
Gln Tyr Lys Lys Lys Phe Pro Leu Lys Phe Tyr Gln Glu Ile Phe Glu 
         195                200                205
Ser Pro Phe Leu Thr Glu Thr Gly Glu Tyr Tyr Lys Gln Glu Ala Ser 
     210                215                220
Asn Leu Leu Gln Glu Ser Asn Cys Ser Gln Tyr Met Glu Lys Val Leu 
 225                230                235                240
Gly Arg Leu Lys Asp Glu Glu Ile Arg Cys Arg Lys Tyr Leu His Pro 
                 245                250                255
Ser Ser Tyr Thr Lys Val Ile His Glu Cys Gln Gln Arg Met Val Ala 
             260                265                270
Asp His Leu Gln Phe Leu His Ala Glu Cys His Asn Ile Ile Arg Gln 
         275                280                285
Glu Lys Lys Asn Asp Met Ala Asn Met Tyr Val Leu Leu Arg Ala Val 
     290                295                300
Ser Thr Gly Leu Pro His Met Ile Gln Glu Leu Gln Asn His Ile His 
 305                310                315                320
Asp Glu Gly Leu Arg Ala Thr Ser Asn Leu Thr Gln Glu Asn Met Pro 
                 325                330                335
Thr Leu Phe Val Glu Ser Val Leu Glu Val His Gly Lys Phe Val Gln 
             340                345                350
Leu Ile Asn Thr Val Leu Asn Gly Asp Gln His Phe Met Ser Ala Leu 
         355                360                365
Asp Lys Ala Leu Thr Ser Val Val Asn Tyr Arg Glu Pro Lys Ser Val 
     370                375                380
Cys Lys Ala Pro Glu Leu Leu Ala Lys Tyr Cys Asp Asn Leu Leu Lys 
 385                390                395                400
Lys Ser Ala Lys Gly Met Thr Glu Asn Glu Val Glu Asp Arg Leu Thr 
                 405                410                415
Ser Phe Ile Thr Val Phe Lys Tyr Ile Asp Asp Lys Asp Val Phe Gln 
             420                425                430
Lys Phe Tyr Ala Arg Met Leu Ala Lys Arg Leu Ile His Gly Leu Ser 
         435                440                445
Met Ser Met Asp Ser Glu Glu Ala Met Ile Asn Lys Leu Lys Gln Ala 
     450                455                460
Cys Gly Tyr Glu Phe Thr Ser Lys Leu His Arg Met Tyr Thr Asp Met 
 465                470                475                480
Ser Val Ser Ala Asp Leu Asn Asn Lys Phe Asn Asn Phe Ile Lys Asn 
                 485                490                495
Gln Asp Thr Val Ile Asp Leu Gly Ile Ser Phe Gln Ile Tyr Val Leu 
             500                505                510
Gln Ala Gly Ala Trp Pro Leu Thr Gln Ala Pro Ser Ser Thr Phe Ala 
         515                520                525
Ile Pro Gln Glu Leu Glu Lys Ser Val Gln Met Phe Glu Leu Phe Tyr 
     530                535                540
Ser Gln His Phe Ser Gly Arg Lys Leu Thr Trp Leu His Tyr Leu Cys 
 545                550                555                560
Thr Gly Glu Val Lys Met Asn Tyr Leu Gly Lys Pro Tyr Val Ala Met 
                 565                570                575
Val Thr Thr Tyr Gln Met Ala Val Leu Leu Ala Phe Asn Asn Ser Glu 
             580                585                590
Thr Val Ser Tyr Lys Glu Leu Gln Asp Ser Thr Gln Met Asn Glu Lys 
         595                600                605
Glu Leu Thr Lys Thr Ile Lys Ser Leu Leu Asp Val Lys Met Ile Asn 
     610                615                620
His Asp Ser Glu Lys Glu Asp Ile Asp Ala Glu Ser Ser Phe Ser Leu 
 625                630                635                640
Asn Met Asn Phe Ser Ser Lys Arg Thr Lys Phe Lys Ile Thr Thr Ser 
                 645                650                655
Met Gln Lys Asp Thr Pro Gln Glu Met Glu Gln Thr Arg Ser Ala Val 
             660                665                670
Asp Glu Asp Arg Lys Met Tyr Leu Gln Ala Ala Ile Val Arg Ile Met 
         675                680                685
Lys Ala Arg Lys Val Leu Arg His Asn Ala Leu Ile Gln Glu Val Ile 
     690                695                700
Ser Gln Ser Arg Ala Arg Phe Asn Pro Ser Ile Ser Met Ile Lys Lys 
 705                710                715                720
Cys Ile Glu Val Leu Ile Asp Lys Gln Tyr Ile Glu Arg Ser Gln Ala 
                 725                730                735
Ser Ala Asp Glu Tyr Ser Tyr Val Ala 
             740                745



<210> 5352
<211> 516
<212> DNA
<213> Rattus norvegicus
<308> AA875615
<400> 5352

ttttttttt  ttgcctgtc  ccatggtcc  ggtattaaa  gtatatgcc  ccacacctg  60
ctacgtgta  tttttaaaa  ttgttcaat  aaaagtatc  ctagtatgc  aaagcatac  120
accagttca  aaaaataag  acattcttt  agaactagt  ttaatagtt  ctttaactt  180
aatcattta  tttaaattt  gtttaatcc  cttcaaaaa  aggaaatat  cctatatat  240
atctataat  cccataccc  tctacatat  tatctgtag  ttaaatatc  caattgtag  300
tgtctctga  cacattaaa  gcattacct  ccttggctc  caatatcag  aacttctcc  360
gtgtccatc  ttgtatcat  aagaatgac  gtttcatca  tgccacctt  ctcctcctc  420
tccttctca  aatcttcaa  gtcacccca  gagttttct  ttccctctc  aatctgggc  480
gttccagga  tccacagca  aggtttaga  acactt  516



<210> 5353
<211> 1119
<212> DNA
<213> Homo sapiens
<308> U09215
<400> 5353

atggccgct  cagctttcg  acctggcag  cagtcagat  tcttggtga  gttgaatcg  60
ctcatggaa  gatgtctaa  aaattcgaa  tgtatagac  ctgagtctc  ctgtgttgt  120
gctggtgaa  aggtttggc  aatacgtgt  gacctacat  tattaaatc  tgatggaaa  180
attattgat  ctgccagca  tgctgcaat  gtggcctta  gtcatttcc  aagacctga  240
gtctctgtc  aaggagatg  agtaacact  tatacacct  aagagcgtg  tcctgtacc  300
ttaagtatc  accacatgc  catttgtgt  agttttgcc  ttttccagc  aggaacata  360
ttattggtg  atcccaatg  acgagaaga  cgtgtgatg  atggcttgc  ggtgattgc  420
atgaacaaa  atcgagaga  ttgtactat  cagtccagt  gtgggataa  gctactaaa  480
gatcaagtt  tgagatgca  taaaatcgc  ggtgtgaaa  tagcagaaa  tacagagct  540
atattgaaa  ctttggaga  tgaccaaaa  gtaaggaaa  aaggtggaa  gtttggttt  600
gcagagtct  tagcaaatc  aaggatcac  gcatttaaa  tggaaaagg  ccctattga  660
acctcggat  tagaagaaa  agcagaaga  atcattgct  aagcagaac  tccttcaga  720
gttgtttct  cacctgtgc  atggactcc  ggaactgcc  aaattggag  gggagtaga  780
aactcctgg  gtgatcttg  agactctga  aaggaagat  atgaaggcg  tggtgatca  840
gctatcatt  ttgatggta  aaaaatgga  actggagta  aagtctctg  tattggaag  900
caagagctg  ggtttcacc  tgttggcca  actggactc  agttcctga  ctcagatgc  960
cccataata  tctcagata  tgaagaaga  gaaatgatc  ttttggaac  agacaagaa  1020
ccaaagaaa  taagaacac  gaccaccag  gcaaaacaa  aaaaagcac  aagtaaaaa  1080
ccagtgaaa  gaagaaaaa  gaagagagc  gccaattaa  1119



<210> 5354
<211> 423
<212> PRT
<213> Homo sapiens
<308> Q06265
<400> 5354

Met Asn Leu Cys Leu Gln Arg Leu Asp Gly Arg Gln Thr Tyr Asp Tyr 
  1               5                  10                  15
Arg Asn Ile Arg Ile Ser Phe Gly Thr Asp Tyr Gly Cys Cys Ile Val 
             20                  25                  30
Glu Leu Gly Lys Thr Arg Val Leu Gly Gln Val Ser Cys Glu Leu Val 
         35                  40                  45
Ser Pro Lys Leu Asn Arg Ala Thr Glu Gly Ile Leu Phe Phe Asn Leu 
     50                  55                  60
Glu Leu Ser Gln Met Ala Ala Pro Ala Phe Glu Pro Gly Arg Gln Ser 
 65                  70                  75                  80
Asp Leu Leu Val Lys Leu Asn Arg Leu Met Glu Arg Cys Leu Arg Asn 
                 85                  90                  95
Ser Lys Cys Ile Asp Thr Glu Ser Leu Cys Val Val Ala Gly Glu Lys 
             100                105                110
Val Trp Gln Ile Arg Val Asp Leu His Leu Leu Asn His Asp Gly Asn 
         115                120                125
Ile Ile Asp Ala Ala Ser Ile Ala Ala Ile Val Ala Leu Cys His Phe 
     130                135                140
Arg Arg Pro Asp Val Ser Val Gln Gly Asp Glu Val Thr Leu Tyr Thr 
 145                150                155                160
Pro Glu Glu Arg Asp Pro Val Pro Leu Ser Ile His His Met Pro Ile 
                 165                170                175
Cys Val Ser Phe Ala Phe Phe Gln Gln Gly Thr Tyr Leu Leu Val Asp 
             180                185                190
Pro Asn Glu Arg Glu Glu Arg Val Met Asp Gly Leu Leu Val Ile Ala 
         195                200                205
Met Asn Lys His Arg Glu Ile Cys Thr Ile Gln Ser Ser Gly Gly Ile 
     210                215                220
Met Leu Leu Lys Asp Gln Val Leu Arg Cys Ser Lys Ile Ala Gly Val 
 225                230                235                240
Lys Val Ala Glu Ile Thr Glu Leu Ile Leu Lys Ala Leu Glu Asn Asp 
                 245                250                255
Gln Lys Val Arg Lys Glu Gly Gly Lys Phe Gly Phe Ala Glu Ser Ile 
             260                265                270
Ala Asn Gln Arg Ile Thr Ala Phe Lys Met Glu Lys Ala Pro Ile Asp 
         275                280                285
Thr Ser Asp Val Glu Glu Lys Ala Glu Glu Ile Ile Ala Glu Ala Glu 
     290                295                300
Pro Pro Ser Glu Val Val Ser Thr Pro Val Leu Trp Thr Pro Gly Thr 
 305                310                315                320
Ala Gln Ile Gly Glu Gly Val Glu Asn Ser Trp Gly Asp Leu Glu Asp 
                 325                330                335
Ser Glu Lys Glu Asp Asp Glu Gly Gly Gly Asp Gln Ala Ile Ile Leu 
             340                345                350
Asp Gly Ile Lys Met Asp Thr Gly Val Glu Val Ser Asp Ile Gly Ser 
         355                360                365
Gln Asp Ala Pro Ile Ile Leu Ser Asp Ser Glu Glu Glu Glu Met Ile 
     370                375                380
Ile Leu Glu Pro Asp Lys Asn Pro Lys Lys Ile Arg Thr Gln Thr Thr 
 385                390                395                400
Ser Ala Lys Gln Glu Lys Ala Pro Ser Lys Lys Pro Val Lys Arg Arg 
                 405                410                415
Lys Lys Lys Arg Ala Ala Asn 
             420



<210> 5355
<211> 413
<212> DNA
<213> Rattus norvegicus
<308> AA875630
<400> 5355

ttttttttt  tttttttag  aacaagaac  tgttttatt  ttccagata  agaagtttg  60
atgttttgc  aatattgct  gagagcaac  ctcatatgt  cagtgcctt  tgtctagca  120
cgcgtaaac  caaatacgt  tccacagtg  aatgttggc  cagccagga  ccaccttgc  180
tatataccg  agaacgact  atcgaacca  aactttttt  ttttttttg  tcctttttt  240
tcggagctg  tttatcaaa  gcgactttc  ataggtgga  agttcttta  cagacagaa  300
gtaggtagt  cacatcttt  taaatgata  cattgtttg  aaataacag  ttccagtgc  360
ccaacatag  ggtgaattc  ctctgaccc  aactgggag  ggagcccct  aac  413



<210> 5356
<211> 441
<212> DNA
<213> Rattus norvegicus
<308> AA875659
<400> 5356

ttttttttt  tttttttaa  caacagcat  acatttttt  gctggaact  gtggtgatt  60
cttctatag  tgacttttc  gttttcttc  tagatacca  cgtttcctc  agtgtttct  120
cgaaacttt  ccctacctt  gatgttttc  tagtgactt  cttagaagc  ccttcttcc  180
cttcctcct  ctcctcctc  tcctttttc  gggacagcc  agcggatga  actttggag  240
ttgtagaac  aaggattct  ngagggagc  aataactgg  attgggaag  ggattcagc  300
ctgagatgc  taacccgct  gtgctaaat  gtgtctctt  gccttccag  agcttcctg  360
aagctgcta  ctcaatgtc  agagccatt  tgacattga  caagtcctg  tattcccga  420
ggtggcggg  catctcgct  t  441



<210> 5357
<211> 505
<212> PRT
<213> Rattus norvegicus
<308> NP_062001
<400> 5357

Met Ser Phe Gly Ser Glu His Tyr Leu Cys Ser Ala Ser Ser Tyr Arg 
  1               5                  10                  15
Lys Val Phe Gly Asp Gly Ser Arg Leu Ser Ala Arg Leu Ser Gly Pro 
             20                  25                  30
Gly Ala Ser Gly Ser Phe Arg Ser Gln Ser Leu Ser Arg Ser Asn Val 
         35                  40                  45
Ala Ser Thr Ala Ala Cys Ser Ser Ala Ser Ser Leu Gly Leu Gly Leu 
     50                  55                  60
Ala Tyr Arg Arg Leu Pro Ala Ser Asp Gly Leu Asp Leu Ser Gln Ala 
 65                  70                  75                  80
Ala Ala Arg Thr Asn Glu Tyr Lys Ile Ile Arg Thr Asn Glu Lys Glu 
                 85                  90                  95
Gln Leu Gln Gly Leu Asn Asp Arg Phe Ala Val Phe Ile Glu Lys Val 
             100                105                110
His Gln Leu Glu Thr Gln Asn Arg Ala Leu Glu Ala Glu Leu Ala Ala 
         115                120                125
Leu Arg Gln Arg His Ala Glu Pro Ser Arg Val Gly Glu Leu Phe Gln 
     130                135                140
Arg Glu Leu Arg Glu Leu Arg Ala Gln Leu Glu Glu Ala Ser Ser Ala 
 145                150                155                160
Arg Ala Gln Ala Leu Leu Glu Arg Asp Gly Leu Ala Glu Glu Val Gln 
                 165                170                175
Arg Leu Arg Ala Arg Cys Glu Glu Glu Ser Arg Gly Arg Glu Gly Ala 
             180                185                190
Glu Arg Ala Leu Lys Ala Gln Gln Arg Asp Val Asp Gly Ala Thr Leu 
         195                200                205
Ala Arg Leu Asp Leu Glu Lys Lys Val Glu Ser Leu Leu Asp Glu Leu 
     210                215                220
Ala Phe Val Arg Gln Val His Asp Glu Glu Val Ala Glu Leu Leu Ala 
 225                230                235                240
Thr Leu Gln Ala Ser Ser Gln Ala Ala Ala Glu Val Asp Val Ala Val 
                 245                250                255
Ala Lys Pro Asp Leu Thr Ser Ala Leu Arg Glu Ile Arg Ala Gln Tyr 
             260                265                270
Glu Ser Leu Ala Ala Lys Asn Leu Gln Ser Ala Glu Glu Trp Tyr Lys 
         275                280                285
Ser Lys Phe Ala Asn Leu Asn Glu Gln Ala Ala Arg Ser Thr Glu Ala 
     290                295                300
Ile Arg Ala Ser Arg Glu Glu Ile His Glu Tyr Arg Arg Gln Leu Gln 
 305                310                315                320
Ala Arg Thr Ile Glu Ile Glu Gly Leu Arg Gly Ala Asn Glu Ser Leu 
                 325                330                335
Glu Arg Gln Ile Leu Glu Leu Glu Glu Arg His Ser Ala Glu Val Ala 
             340                345                350
Gly Tyr Gln Asp Ser Ile Gly Gln Leu Glu Ser Asp Leu Arg Asn Thr 
         355                360                365
Lys Ser Glu Met Ala Arg His Leu Arg Glu Tyr Gln Asp Leu Leu Asn 
     370                375                380
Val Lys Met Ala Leu Asp Ile Glu Ile Ala Ala Tyr Arg Lys Leu Leu 
 385                390                395                400
Glu Gly Glu Glu Thr Arg Phe Ser Thr Ser Gly Leu Ser Ile Ser Gly 
                 405                410                415
Leu Asn Pro Leu Pro Asn Pro Ser Tyr Leu Leu Pro Pro Arg Ile Leu 
             420                425                430
Ser Ser Thr Thr Ser Lys Val Ser Ser Ala Gly Leu Ser Leu Lys Lys 
         435                440                445
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala Ser Lys Glu Val 
     450                455                460
Thr Lys Lys Thr Ser Lys Val Gly Glu Ser Phe Glu Glu Thr Leu Glu 
 465                470                475                480
Glu Thr Val Val Ser Thr Lys Lys Thr Glu Lys Ser Thr Ile Glu Glu 
                 485                490                495
Ile Thr Thr Ser Ser Ser Gln Lys Met 
             500                505



<210> 5358
<211> 3252
<212> DNA
<213> Homo sapiens
<308> NM_032727
<400> 5358

ggcacgagg  ttctgtagc  cgcgttgaa  ccgcacgtc  ggccccgat  ccggcacca  60
gagcttcgg  tcggagcac  acctgtgct  ctcctcctc  taccgcaag  tgttcgggg  120
tggctctcg  ctgtccgcc  gcctctctg  ggccggcgg  gcgggcggc  tccgctcgc  180
gtcgctgtc  cgcagcaat  tggcctcct  ggccgcctg  tcctcggcc  cgtcgctcg  240
cctcggcct  gcctatcgc  ggccgccgg  gtccgacgg  ctggacctg  gccaggcgg  300
ggcgcgcac  aacgagtac  agatcatcc  caccaacga  aaggagcag  tgcagggcc  360
caacgaccg  ttcgccgtg  tcatcgaga  ggtgcatca  ctggagacg  agaaccgcg  420
gttggaggc  gagctggcc  cgctgcgac  gcgccacgc  gagccgtcg  gcgtcggcg  480
gctcttcca  cgcgagctg  gcgacctgc  cgcgcagct  gaggaggcc  gctcggctc  540
ctcgcaggc  ctgctggag  gcgacgggc  ggcggagga  gtgcagcgg  tgcgggcgc  600
ctgcgagga  gagagccgc  gacgcgaag  cgccgagcg  gccctgaag  cgcagcagc  660
cgacgtgga  ggcgccacg  tggcccgcc  ggacctgga  aagaaggtg  agtcgctgc  720
ggacgagct  gccttcgta  gccaggtgc  cgacgagga  gtagccgag  tgctggcca  780
gctgcaggc  tcgtcgcag  ccgcggccg  ggtggacgt  actgtggct  aaccagacc  840
gacctcggc  ctgagggag  tccgcgccc  gtatgagtc  ctggccgct  agaacctgc  900
gtccgcgga  gaatggtac  agtccaagt  tgccaacct  aacgagcag  cggcgcgca  960
caccgaggc  atccgggcc  gccgcgagg  gatccacga  tatcggcgc  agctgcagg  1020
gcgcaccat  gagatcgag  gcctgcgcg  ggccaacga  tccttggag  ggcagatcc  1080
ggagctgga  gagcggcac  gtgccgagg  agctggcta  caggatagc  ttgggcagc  1140
ggagaatga  ctgaggaac  ccaagagtg  gatggcacg  caccttcgg  aataccagg  1200
cttgctcaa  gtcaaaatg  ctcttgaca  tgagatagc  gcttacagg  aactgctgg  1260
aggcgagga  acacgtttt  gcaccagtg  gttaagcat  tcggggctg  atccacttc  1320
caatccaag  tacctgctc  cacctagaa  cctcagtgc  acaacctcc  aagtctcat  1380
cactgggct  tcacttaag  aagaggagg  ggaggagga  gcatctaag  tagcctcta  1440
gaaaacctc  cagataggg  aaagttttg  agaaatatt  gaggagaca  taatatcta  1500
taagaaaac  gagaaatca  atatagaag  aaccaccat  tcaagccaa  aaatataat  1560
ccattgctt  gaaaaagtt  atgcttaag  gggaatgat  tgcatttga  ttgttaaac  1620
gcctattcc  gaactataa  acctgccac  actataaaa  gtcttcaag  cttcagtct  1680
atatttagt  ttgaatact  acattctct  ataagaaaa  cacccctta  attgaagta  1740
actgcagtc  tggagcaat  acagatgag  tatctaaga  tacagcttt  tgaccttca  1800
ctcacgctt  acagtgatc  atgattcag  tgcagagga  gtacaaact  aggtgctaa  1860
tctgcgatc  tcgtcattt  ctgtgaact  aaattaaaa  tattcatgc  acccagcca  1920
tacccagct  aataatctt  ctctagata  ctaaaacat  agatcactg  cagagataa  1980
ctaatggtc  acacccaat  ccactctga  agaattatt  cacaaataa  aggtgtttg  2040
ttaatggac  cttttcacc  ccttcaatt  catatatcc  tttcttcta  gtaggaaaa  2100
aatagtcta  tgtagtatt  ttccctttt  aacacattt  ggttcttct  aaaagaact  2160
acccccatt  gcgctctgc  cagtgggta  aattagatg  atgttgacc  tgtctatga  2220
tcgtgtaat  acttatccc  gcccatttc  tattctttc  attctgtag  ttaaaaaaa  2280
ggcagtgat  aattttaag  gtttccccc  acatataaa  taatgcaaa  aatccctag  2340
ctttaggct  tcagcttac  caaatctat  taattagga  aaaaaacta  taaggatgt  2400
gcttttcac  tttacttta  aagcacagt  aatatccca  actgtgatg  agccgacct  2460
agatttagt  gtgtaagct  gaagaagtg  gtgtttcta  gagtggaaa  agccaaggt  2520
tcatttatg  gtcagttca  ttgtggtga  atagaatta  ctttttcat  cccttaccc  2580
tagaatcca  gtattcccc  tcccactag  ctaggtcat  aagaggcgt  gctttcact  2640
tcctatgcc  tttacgagt  ctaagtgta  gatattttg  caccagaac  caatgctac  2700
gccccaaag  aaaagaaac  acttctggt  aatcaacac  accagcgta  atataagaa  2760
gacatcttt  tcttttcta  aagacttcc  taacactta  cccatggct  cacagttgg  2820
ggggtcctg  cggagagga  gagacactc  gaccagaga  ggggtgtgc  tgcgcctac  2880
cgcttgcta  aagtagatt  tggacagtc  gctcttcat  tgcccaact  tgtagcatc  2940
gcattgccc  gtctttcat  tgtgccaag  ctgatgcag  atttgttct  tgtccagca  3000
tcacttcgg  cagagctga  gagttgccc  gtctctgtt  catgtctcc  ttaagagct  3060
tggtgataa  gacatgatg  ttttactga  ctttcttat  ctagcacat  cttcaatag  3120
tcaaggaac  tgaaaaata  ttttcctta  ctttacccc  tccctgtct  tactcctca  3180
acttactgt  agacattag  aacataata  attaaaagt  acacgaatc  caccaaaaa  3240
aaaaaaaaa  aa  3252



<210> 5359
<211> 499
<212> PRT
<213> Homo sapiens
<308> Q16352
<400> 5359

Met Ser Phe Gly Ser Glu His Tyr Leu Cys Ser Ser Ser Ser Tyr Arg 
  1               5                  10                  15
Lys Val Phe Gly Asp Gly Ser Arg Leu Ser Ala Arg Leu Ser Gly Ala 
             20                  25                  30
Gly Gly Ala Gly Gly Phe Arg Ser Gln Ser Leu Ser Arg Ser Asn Val 
         35                  40                  45
Ala Ser Ser Ala Ala Cys Ser Ser Ala Ser Ser Leu Gly Leu Gly Leu 
     50                  55                  60
Ala Tyr Arg Arg Pro Pro Ala Ser Asp Gly Leu Asp Leu Ser Gln Ala 
 65                  70                  75                  80
Ala Ala Arg Thr Asn Glu Tyr Lys Ile Ile Arg Thr Asn Glu Lys Glu 
                 85                  90                  95
Gln Leu Gln Gly Leu Asn Asp Arg Phe Ala Val Phe Ile Glu Lys Val 
             100                105                110
His Gln Leu Glu Thr Gln Asn Arg Ala Leu Glu Ala Glu Leu Ala Ala 
         115                120                125
Leu Arg Gln Arg His Ala Glu Pro Ser Arg Val Gly Glu Leu Phe Gln 
     130                135                140
Arg Glu Leu Arg Asp Leu Arg Ala Gln Leu Glu Glu Ala Ser Ser Ala 
 145                150                155                160
Arg Ser Gln Ala Leu Leu Glu Arg Asp Gly Leu Ala Glu Glu Val Gln 
                 165                170                175
Arg Leu Arg Ala Arg Cys Glu Glu Glu Ser Arg Gly Arg Glu Gly Ala 
             180                185                190
Glu Arg Ala Leu Lys Ala Gln Gln Arg Asp Val Asp Gly Ala Thr Leu 
         195                200                205
Ala Arg Leu Asp Leu Glu Lys Lys Val Glu Ser Leu Leu Asp Glu Leu 
     210                215                220
Ala Phe Val Arg Gln Val His Asp Glu Glu Val Ala Glu Leu Leu Ala 
 225                230                235                240
Thr Leu Gln Ala Ser Ser Gln Ala Ala Ala Glu Val Asp Val Thr Val 
                 245                250                255
Ala Lys Pro Asp Leu Thr Ser Ala Leu Arg Glu Ile Arg Ala Gln Tyr 
             260                265                270
Glu Ser Leu Ala Ala Lys Asn Leu Gln Ser Ala Glu Glu Trp Tyr Lys 
         275                280                285
Ser Lys Phe Ala Asn Leu Asn Glu Gln Ala Ala Arg Ser Thr Glu Ala 
     290                295                300
Ile Arg Ala Ser Arg Glu Glu Ile His Glu Tyr Arg Arg Gln Leu Gln 
 305                310                315                320
Ala Arg Thr Ile Glu Ile Glu Gly Leu Arg Gly Ala Asn Glu Ser Leu 
                 325                330                335
Glu Arg Gln Ile Leu Glu Leu Glu Glu Arg His Ser Ala Glu Val Ala 
             340                345                350
Gly Tyr Gln Asp Ser Ile Gly Gln Leu Glu Asn Asp Leu Arg Asn Thr 
         355                360                365
Lys Ser Glu Met Ala Arg His Leu Arg Glu Tyr Gln Asp Leu Leu Asn 
     370                375                380
Val Lys Met Ala Leu Asp Ile Glu Ile Ala Ala Tyr Arg Lys Leu Leu 
 385                390                395                400
Glu Gly Glu Glu Thr Arg Phe Ser Thr Ser Gly Leu Ser Ile Ser Gly 
                 405                410                415
Leu Asn Pro Leu Pro Asn Pro Ser Tyr Leu Leu Pro Pro Arg Ile Leu 
             420                425                430
Ser Ala Thr Thr Ser Lys Val Ser Ser Thr Gly Leu Ser Leu Lys Lys 
         435                440                445
Glu Glu Glu Glu Glu Glu Ala Ser Lys Val Ala Ser Lys Lys Thr Ser 
     450                455                460
Gln Ile Gly Glu Ser Phe Glu Glu Ile Leu Glu Glu Thr Val Ile Ser 
 465                470                475                480
Thr Lys Lys Thr Glu Lys Ser Asn Ile Glu Glu Thr Thr Ile Ser Ser 
                 485                490                495
Gln Lys Ile 
             500



<210> 5360
<211> 401
<212> DNA
<213> Rattus norvegicus
<308> AA891037
<400> 5360

actccatcc  aggtgtgct  cattccagg  atcttagac  tttcccgag  tctccggct  60
ctctttctc  agatgtttc  tttgggggc  catgaaggc  ctcttctcc  gcgctgtct  120
gaagcatcc  tggccaaac  tagaagtgg  gtcaatgaa  ttgagctca  tattctcca  180
ggccctgcg  ctgtggtgc  ctagtagat  cgttgtttc  gaccatctt  ccgtcttcc  240
tgtgcagcc  ccggccaat  cggtagatc  tcttgttca  ctctgtacg  tggtggtaa  300
ccttctgcc  agcccgggc  atggagcag  ctactcggg  agggtgcca  gcaccaata  360
aggccacct  gcgcaggcc  ttgtgggtc  tcctaggaa  c  401



<210> 5361
<211> 402
<212> PRT
<213> Rattus norvegicus
<308> R5RT3L
<400> 5361

Ser His Arg Lys Phe Ser Ala Pro Arg His Gly Ser Leu Gly Phe Leu 
  1               5                  10                  15
Pro Arg Lys Arg Ser Ser Arg His Arg Gly Lys Val Lys Ser Phe Pro 
             20                  25                  30
Lys Asp Asp Pro Ser Lys Pro Val His Leu Thr Ala Phe Leu Gly Tyr 
         35                  40                  45
Lys Ala Gly Met Thr His Ile Val Arg Glu Val Asp Arg Pro Gly Ser 
     50                  55                  60
Lys Val Asn Lys Lys Glu Val Val Glu Ala Val Thr Ile Val Glu Thr 
 65                  70                  75                  80
Pro Pro Met Val Val Val Gly Ile Val Gly Tyr Val Glu Thr Pro Arg 
                 85                  90                  95
Gly Leu Arg Thr Phe Lys Thr Val Phe Ala Glu His Ile Ser Asp Glu 
             100                105                110
Cys Lys Arg Arg Phe Tyr Lys Asn Trp His Lys Ser Lys Lys Lys Ala 
         115                120                125
Phe Thr Lys Tyr Cys Lys Lys Trp Gln Asp Asp Thr Gly Lys Lys Gln 
     130                135                140
Leu Glu Lys Asp Phe Asn Ser Met Lys Lys Tyr Cys Gln Val Ile Arg 
 145                150                155                160
Ile Ile Ala His Thr Gln Met Arg Leu Leu Pro Leu Arg Gln Lys Lys 
                 165                170                175
Ala His Leu Met Glu Ile Gln Val Asn Gly Gly Thr Val Ala Glu Lys 
             180                185                190
Leu Asp Trp Ala Arg Glu Arg Leu Glu Gln Gln Val Pro Val Asn Gln 
         195                200                205
Val Phe Gly Gln Asp Glu Met Ile Asp Val Ile Gly Val Thr Lys Gly 
     210                215                220
Lys Gly Tyr Lys Gly Val Thr Ser Arg Trp His Thr Lys Lys Leu Pro 
 225                230                235                240
Arg Lys Thr His Arg Gly Leu Arg Lys Val Ala Cys Ile Gly Ala Trp 
                 245                250                255
His Pro Ala Arg Val Ala Phe Ser Val Ala Arg Ala Gly Gln Lys Gly 
             260                265                270
Tyr His His Arg Thr Glu Ile Asn Lys Lys Ile Tyr Lys Ile Gly Gln 
         275                280                285
Gly Tyr Leu Ile Lys Asp Gly Lys Leu Ile Lys Asn Asn Ala Ser Thr 
     290                295                300
Asp Tyr Asp Leu Ser Asp Lys Ser Ile Asn Pro Leu Gly Gly Phe Val 
 305                310                315                320
His Tyr Gly Glu Val Thr Asn Asp Phe Ile Met Leu Lys Gly Cys Val 
                 325                330                335
Val Gly Thr Lys Lys Arg Val Leu Thr Leu Arg Lys Ser Leu Leu Val 
             340                345                350
Gln Thr Lys Arg Arg Ala Leu Glu Lys Ile Asp Leu Lys Phe Ile Asp 
         355                360                365
Thr Thr Ser Lys Phe Gly His Gly Arg Phe Gln Thr Met Glu Glu Lys 
     370                375                380
Lys Ala Phe Met Gly Pro Leu Lys Lys Asp Arg Ile Ala Lys Glu Glu 
 385                390                395                400
Gly Ala 
                 405



<210> 5362
<211> 1548
<212> DNA
<213> Homo sapiens
<308> U65581
<400> 5362

ggcggctag  ggcgaggcc  cttcctgta  cttcaggga  cggccacca  gtcccaccg  60
aagttttcc  cccctcggc  cggacacct  ggcttcctg  cccataaga  gagccaccg  120
caccggggc  aggtgaaga  gtggccgcg  gatgacccc  gccagcccg  gcacctcac  180
gccttcctg  gctacaagg  gggcatgac  cacaccctg  gggaggtgc  ccggccggg  240
ctcaaaatt  ccaaacggg  ggaggtgga  gcggtgaca  ttgtagaaa  gccgcccct  300
gtggtggtg  gcgtggtgg  ctacgtggc  acccctcga  gtctccgga  cttcaagac  360
atctttgca  aacacctca  tgatgagtg  cggcgccga  tctacaagg  ctggcacaa  420
agcaagaag  aagccttca  caaggcctg  aagaggtgg  gggacacag  cgggaaaaa  480
cagctacag  aggacttcg  cgccatgaa  aagtactgc  aggtcattc  ggtcattgt  540
cacactcag  tgaaactgc  gcccttccg  cagaagaag  cccacatca  ggagatcca  600
ctgaacggt  gcacggtgg  cgagaaggt  gcctgggcc  aggcccggc  ggagaagca  660
gtgcccgtg  acagcgtgt  cagccagag  gaggtcatt  atgtcattg  tgtcaccaa  720
ggtcgaggc  tcaaagggg  cacaagccg  tggcatacc  agaagctgc  gcggaagac  780
cataagggc  tgcgcaagg  ggcctgcat  ggcgcctgg  accccgccc  cgtgggctg  840
tccattgct  gggccgggc  gaagggcta  caccaccgc  cggagctca  caagaagat  900
ttccgcatc  gcaggggcc  gcacatgga  gacgggaag  tggtgaaga  caatgcatc  960
accagctac  acgtgactg  caagtccat  acaccgctg  gtggcttcc  ccactacgg  1020
gaagtgaac  acgacttcg  catgctgaa  ggttgtatt  ctggtacca  gaagcgggt  1080
attacgctg  gaaagtccc  cctggtgca  cacagtcgc  aagccgtgg  gaatattga  1140
ctcaagttc  ttgacacca  ctccaagtt  ggccatggc  gcttccaga  agcccaaga  1200
aagagggcc  tcatgggcc  ccaaaagaa  catctggag  aggaaacgc  ggagacctc  1260
ggagacttg  aggctgtgt  gggtggatg  accctgaag  gcaccgcac  gtctgcccc  1320
atgtctaac  aaggccgga  gcgactctt  ctgcgaggt  tcagagcgc  gtgtaaccg  1380
ccaaggggt  caccttgcc  gctgcctag  caaagccga  tcattaaga  aggggaatt  1440
caatagaga  agagtaatt  acacagagc  ggctgtgcg  gagaccgga  ttttatgtt  1500
tattattac  caaatcgat  tctttgagc  aaaaaaaaa  aaaaaaaa  1548



<210> 5363
<211> 406
<212> PRT
<213> Homo sapiens
<308> Q92901
<400> 5363

Ser His Arg Lys Phe Ser Ala Pro Arg His Gly His Leu Gly Phe Leu 
  1               5                  10                  15
Pro His Lys Arg Ser His Arg His Arg Gly Lys Val Lys Thr Trp Pro 
             20                  25                  30
Arg Asp Asp Pro Ser Gln Pro Val His Leu Thr Ala Phe Leu Gly Tyr 
         35                  40                  45
Lys Ala Gly Met Thr His Thr Leu Arg Glu Val His Arg Pro Gly Leu 
     50                  55                  60
Lys Ile Ser Lys Arg Glu Glu Val Glu Ala Val Thr Ile Val Glu Thr 
 65                  70                  75                  80
Pro Pro Leu Val Val Val Gly Val Val Gly Tyr Val Ala Thr Pro Arg 
                 85                  90                  95
Gly Leu Arg Ser Phe Lys Thr Ile Phe Ala Glu His Leu Ser Asp Glu 
             100                105                110
Cys Arg Arg Arg Phe Tyr Lys Asp Trp His Lys Ser Lys Lys Lys Ala 
         115                120                125
Phe Thr Lys Ala Cys Lys Arg Trp Arg Asp Thr Asp Gly Lys Lys Gln 
     130                135                140
Leu Gln Lys Asp Phe Ala Ala Met Lys Lys Tyr Cys Lys Val Ile Arg 
 145                150                155                160
Val Ile Val His Thr Gln Met Lys Leu Leu Pro Phe Arg Gln Lys Lys 
                 165                170                175
Ala His Ile Met Glu Ile Gln Leu Asn Gly Gly Thr Val Ala Glu Lys 
             180                185                190
Val Ala Trp Ala Gln Ala Arg Leu Glu Lys Gln Val Pro Val His Ser 
         195                200                205
Val Phe Ser Gln Ser Glu Val Ile Asp Val Ile Ala Val Thr Lys Gly 
     210                215                220
Arg Gly Val Lys Gly Val Thr Ser Arg Trp His Thr Lys Lys Leu Pro 
 225                230                235                240
Arg Lys Thr His Lys Gly Leu Arg Lys Val Ala Cys Ile Gly Ala Trp 
                 245                250                255
His Pro Ala Arg Val Gly Cys Ser Ile Ala Arg Ala Gly Gln Lys Gly 
             260                265                270
Tyr His His Arg Thr Glu Leu Asn Lys Lys Ile Phe Arg Ile Gly Arg 
         275                280                285
Gly Pro His Met Glu Asp Gly Lys Leu Val Lys Asn Asn Ala Ser Thr 
     290                295                300
Ser Tyr Asp Val Thr Ala Lys Ser Ile Thr Pro Leu Gly Gly Phe Pro 
 305                310                315                320
His Tyr Gly Glu Val Asn Asn Asp Phe Val Met Leu Lys Gly Cys Ile 
                 325                330                335
Ala Gly Thr Lys Lys Arg Val Ile Thr Leu Arg Lys Ser Leu Leu Val 
             340                345                350
His His Ser Arg Gln Ala Val Glu Asn Ile Glu Leu Lys Phe Ile Asp 
         355                360                365
Thr Thr Ser Lys Phe Gly His Gly Arg Phe Gln Thr Ala Gln Glu Lys 
     370                375                380
Arg Ala Phe Met Gly Pro Gln Lys Lys His Leu Glu Lys Glu Thr Pro 
 385                390                395                400
Glu Thr Ser Gly Asp Leu 
                 405



<210> 5364
<211> 455
<212> DNA
<213> Rattus norvegicus
<308> AA891049
<400> 5364

gaccaaaac  tttaattaa  aacaacaaa  aaaattaca  tagcagaaa  ataataata  60
caataacaa  gaaattaga  gtgggaatc  gggtaaaat  gaatgcaga  gccttagtc  120
ctaagagac  agcacccct  ctgagctgg  cttagcccc  gctccttct  agttttcct  180
ggctgctgg  ttctcatct  ctcccataa  acgaatgtt  tgcttttcc  ggaattcat  240
gagttcttt  ccctttgcc  gaagctgct  tgacagtgt  tcaatgatc  tttgtatct  300
ctccttgtt  ccctccaag  caggcagca  ctccttgac  gtccgctct  ccagcacac  360
gccaaccat  cggtagcac  tgcgggtct  atccacttc  ttcagcgta  cgatcacca  420
ctatgctca  tcagttcca  ctccagctc  gctgc  455



<210> 5365
<211> 154
<212> PRT
<213> Rattus norvegicus
<308> NP_035200
<400> 5365

Met Ala Asp Ser Ser Gly Arg Val Gly Lys Ser Gly Gly Thr Ala Arg 
  1               5                  10                  15
Trp Lys Gly Ala Val Ser Ala Glu Gln Val Ile Ala Gly Phe Asn Arg 
             20                  25                  30
Leu Arg Gln Glu Gln Arg Gly Leu Ala Ser Lys Ala Ala Glu Leu Glu 
         35                  40                  45
Met Glu Leu Asn Glu His Ser Leu Val Ile Asp Thr Leu Lys Glu Val 
     50                  55                  60
Asp Glu Thr Arg Lys Cys Tyr Arg Met Val Gly Gly Val Leu Val Glu 
 65                  70                  75                  80
Arg Thr Val Lys Glu Val Leu Pro Ala Leu Glu Gly Asn Lys Glu Gln 
                 85                  90                  95
Ile Gln Lys Ile Ile Glu Thr Leu Ser Gln Gln Leu Gln Ala Lys Gly 
             100                105                110
Lys Glu Leu Asn Glu Phe Arg Glu Lys His Asn Ile Arg Leu Met Gly 
         115                120                125
Glu Asp Glu Lys Pro Ala Ala Lys Glu Asn Ser Glu Gly Ala Gly Ala 
     130                135                140
Lys Ala Ser Ser Ala Gly Val Leu Val Ser 
 145                150



<210> 5366
<211> 644
<212> DNA
<213> Homo sapiens
<308> NM_012394
<400> 5366

gctccctgg  gaacccagc  ggcggcgaa  atggcggag  acagcggtc  cgccggcaa  60
agcagcggg  gcggcgcgg  gaagggggc  gtgtccgca  agcaggtga  tgctggctt  120
aaccgcctt  ggcaggaac  gcgaggcct  gcatccaaa  cagctgagt  ggagatgga  180
ttgaatgag  acagcctag  gatcgatac  ctgaaggag  tagatgaaa  tcgtaagtg  240
taccgcatg  ttggaggag  gctggtgga  cgaactgtc  aagaggtgc  gcccgcttt  300
gagaacaac  aggagcaga  acagaagat  attgagaca  tgacacagc  gcttcaggc  360
aagggaaaa  aactaaatg  attccggga  aagcacaac  ttcgtctca  gggagaaga  420
gagaagcca  cagccaagg  aaactcaga  ggggctggg  ctaaggcca  ctcagctgg  480
gtgttggtc  cctagggac  aaggccttt  cattttttt  taccctgac  cccacttct  540
atttctctt  attgttatt  ttattattt  ctctgctat  gtaatattt  tttgttaat  600
aaatgtttt  gtcagaatc  taaaaaaaa  aaaaaaaaa  aaaa  644



<210> 5367
<211> 154
<212> PRT
<213> Homo sapiens
<308> Q9UHV9
<400> 5367

Met Ala Glu Asn Ser Gly Arg Ala Gly Lys Ser Ser Gly Ser Gly Ala 
  1               5                  10                  15
Gly Lys Gly Ala Val Ser Ala Glu Gln Val Ile Ala Gly Phe Asn Arg 
             20                  25                  30
Leu Arg Gln Glu Gln Arg Gly Leu Ala Ser Lys Ala Ala Glu Leu Glu 
         35                  40                  45
Met Glu Leu Asn Glu His Ser Leu Val Ile Asp Thr Leu Lys Glu Val 
     50                  55                  60
Asp Glu Thr Arg Lys Cys Tyr Arg Met Val Gly Gly Val Leu Val Glu 
 65                  70                  75                  80
Arg Thr Val Lys Glu Val Leu Pro Ala Leu Glu Asn Asn Lys Glu Gln 
                 85                  90                  95
Ile Gln Lys Ile Ile Glu Thr Leu Thr Gln Gln Leu Gln Ala Lys Gly 
             100                105                110
Lys Glu Leu Asn Glu Phe Arg Glu Lys His Asn Ile Arg Leu Met Gly 
         115                120                125
Glu Asp Glu Lys Pro Ala Ala Lys Glu Asn Ser Glu Gly Ala Gly Ala 
     130                135                140
Lys Ala Ser Ser Ala Gly Val Leu Val Ser 
 145                150



<210> 5368
<211> 455
<212> DNA
<213> Rattus norvegicus
<308> AA891049
<400> 5368

gaccaaaac  tttaattaa  aacaacaaa  aaaattaca  tagcagaaa  ataataata  60
caataacaa  gaaattaga  gtgggaatc  gggtaaaat  gaatgcaga  gccttagtc  120
ctaagagac  agcacccct  ctgagctgg  cttagcccc  gctccttct  agttttcct  180
ggctgctgg  ttctcatct  ctcccataa  acgaatgtt  tgcttttcc  ggaattcat  240
gagttcttt  ccctttgcc  gaagctgct  tgacagtgt  tcaatgatc  tttgtatct  300
ctccttgtt  ccctccaag  caggcagca  ctccttgac  gtccgctct  ccagcacac  360
gccaaccat  cggtagcac  tgcgggtct  atccacttc  ttcagcgta  cgatcacca  420
ctatgctca  tcagttcca  ctccagctc  gctgc  455



<210> 5369
<211> 154
<212> PRT
<213> Rattus norvegicus
<308> NP_035200
<400> 5369

Met Ala Asp Ser Ser Gly Arg Val Gly Lys Ser Gly Gly Thr Ala Arg 
  1               5                  10                  15
Trp Lys Gly Ala Val Ser Ala Glu Gln Val Ile Ala Gly Phe Asn Arg 
             20                  25                  30
Leu Arg Gln Glu Gln Arg Gly Leu Ala Ser Lys Ala Ala Glu Leu Glu 
         35                  40                  45
Met Glu Leu Asn Glu His Ser Leu Val Ile Asp Thr Leu Lys Glu Val 
     50                  55                  60
Asp Glu Thr Arg Lys Cys Tyr Arg Met Val Gly Gly Val Leu Val Glu 
 65                  70                  75                  80
Arg Thr Val Lys Glu Val Leu Pro Ala Leu Glu Gly Asn Lys Glu Gln 
                 85                  90                  95
Ile Gln Lys Ile Ile Glu Thr Leu Ser Gln Gln Leu Gln Ala Lys Gly 
             100                105                110
Lys Glu Leu Asn Glu Phe Arg Glu Lys His Asn Ile Arg Leu Met Gly 
         115                120                125
Glu Asp Glu Lys Pro Ala Ala Lys Glu Asn Ser Glu Gly Ala Gly Ala 
     130                135                140
Lys Ala Ser Ser Ala Gly Val Leu Val Ser 
 145                150



<210> 5370
<211> 644
<212> DNA
<213> Homo sapiens
<308> NM_012394
<400> 5370

gctccctgg  gaacccagc  ggcggcgaa  atggcggag  acagcggtc  cgccggcaa  60
agcagcggg  gcggcgcgg  gaagggggc  gtgtccgca  agcaggtga  tgctggctt  120
aaccgcctt  ggcaggaac  gcgaggcct  gcatccaaa  cagctgagt  ggagatgga  180
ttgaatgag  acagcctag  gatcgatac  ctgaaggag  tagatgaaa  tcgtaagtg  240
taccgcatg  ttggaggag  gctggtgga  cgaactgtc  aagaggtgc  gcccgcttt  300
gagaacaac  aggagcaga  acagaagat  attgagaca  tgacacagc  gcttcaggc  360
aagggaaaa  aactaaatg  attccggga  aagcacaac  ttcgtctca  gggagaaga  420
gagaagcca  cagccaagg  aaactcaga  ggggctggg  ctaaggcca  ctcagctgg  480
gtgttggtc  cctagggac  aaggccttt  cattttttt  taccctgac  cccacttct  540
atttctctt  attgttatt  ttattattt  ctctgctat  gtaatattt  tttgttaat  600
aaatgtttt  gtcagaatc  taaaaaaaa  aaaaaaaaa  aaaa  644



<210> 5371
<211> 154
<212> PRT
<213> Homo sapiens
<308> Q9UHV9
<400> 5371

Met Ala Glu Asn Ser Gly Arg Ala Gly Lys Ser Ser Gly Ser Gly Ala 
  1               5                  10                  15
Gly Lys Gly Ala Val Ser Ala Glu Gln Val Ile Ala Gly Phe Asn Arg 
             20                  25                  30
Leu Arg Gln Glu Gln Arg Gly Leu Ala Ser Lys Ala Ala Glu Leu Glu 
         35                  40                  45
Met Glu Leu Asn Glu His Ser Leu Val Ile Asp Thr Leu Lys Glu Val 
     50                  55                  60
Asp Glu Thr Arg Lys Cys Tyr Arg Met Val Gly Gly Val Leu Val Glu 
 65                  70                  75                  80
Arg Thr Val Lys Glu Val Leu Pro Ala Leu Glu Asn Asn Lys Glu Gln 
                 85                  90                  95
Ile Gln Lys Ile Ile Glu Thr Leu Thr Gln Gln Leu Gln Ala Lys Gly 
             100                105                110
Lys Glu Leu Asn Glu Phe Arg Glu Lys His Asn Ile Arg Leu Met Gly 
         115                120                125
Glu Asp Glu Lys Pro Ala Ala Lys Glu Asn Ser Glu Gly Ala Gly Ala 
     130                135                140
Lys Ala Ser Ser Ala Gly Val Leu Val Ser 
 145                150



<210> 5372
<211> 508
<212> DNA
<213> Rattus norvegicus
<308> AA891054
<400> 5372

ctcttgttt  aaagtcttg  cgttcaggt  atctggata  tcacctctc  tctgtccca  60
acactccca  gagagtgat  gatgaactc  tctttccta  cggtgtggt  tctcttggc  120
gtgcacacc  acaggcacc  gtggccacg  gcctagatc  caagatgca  gaatcggag  180
ccaaccttg  agggatgtc  tctcggagc  tgaacttgt  ccaggccta  ttttgttgc  240
actacgagt  tgtgctttt  aggcccgag  ggagctcac  ggactcctt  tctcaactc  300
gcgtctctt  ctgtttgtt  ttctatgag  aaggggcac  ttccggtct  gatccggac  360
ttttagact  tctgtcaac  agcctaact  cccccacat  ctttaaatc  aggtaactt  420
ctaaaaccg  atagatcac  tcacgaatg  cctcagatc  tgaattcat  tcaacagca  480
cgtctcaag  acggtcctc  tcctgttg  508



<210> 5373
<211> 457
<212> DNA
<213> Homo sapiens
<308> AW969541
<400> 5373

gccattgca  tccagcctg  gcaacaaga  cgaaactcc  tctcaaaaa  aaaaaagtg  60
cttgttcac  gcagcatgc  cagtgccac  cacaggtgc  gacctatag  aagtgctta  120
catttgttg  ataggggaa  gaaatttcc  gaagtaaat  cagcaatta  taatgttta  180
aagctgggc  tggtcgctc  ggccagtaa  cccagtgac  taggaggct  aggtgggag  240
attacttga  acccacagt  tgagaccag  ctgggcaac  tagtgagac  ctgtctcta  300
aaaaataaa  atagaaata  agtagtgct  attgtttgc  aaaaaaaaa  aaaaaaaaa  360
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  tgaaggcgg  cgaaagctt  420
tccccttaa  ggggggtta  tttaacctg  gcactgg  457



<210> 5374
<211> 501
<212> PRT
<213> Homo sapiens
<308> P11230
<400> 5374

Met Thr Pro Gly Ala Leu Leu Met Leu Leu Gly Ala Leu Gly Ala Pro 
  1               5                  10                  15
Leu Ala Pro Gly Val Arg Gly Ser Glu Ala Glu Gly Arg Leu Arg Glu 
             20                  25                  30
Lys Leu Phe Ser Gly Tyr Asp Ser Ser Val Arg Pro Ala Arg Glu Val 
         35                  40                  45
Gly Asp Arg Val Arg Val Ser Val Gly Leu Ile Leu Ala Gln Leu Ile 
     50                  55                  60
Ser Leu Asn Glu Lys Asp Glu Glu Met Ser Thr Lys Val Tyr Leu Asp 
 65                  70                  75                  80
Leu Glu Trp Thr Asp Tyr Arg Leu Ser Trp Asp Pro Ala Glu His Asp 
                 85                  90                  95
Gly Ile Asp Ser Leu Arg Ile Thr Ala Glu Ser Val Trp Leu Pro Asp 
             100                105                110
Val Val Leu Leu Asn Asn Asn Asp Gly Asn Phe Asp Val Ala Leu Asp 
         115                120                125
Ile Ser Val Val Val Ser Ser Asp Gly Ser Val Arg Trp Gln Pro Pro 
     130                135                140
Gly Ile Tyr Arg Ser Ser Cys Ser Ile Gln Val Thr Tyr Phe Pro Phe 
 145                150                155                160
Asp Trp Gln Asn Cys Thr Met Val Phe Ser Ser Tyr Ser Tyr Asp Ser 
                 165                170                175
Ser Glu Val Ser Leu Gln Thr Gly Leu Gly Pro Asp Gly Gln Gly His 
             180                185                190
Gln Glu Ile His Ile His Glu Gly Thr Phe Ile Glu Asn Gly Gln Trp 
         195                200                205
Glu Ile Ile His Lys Pro Ser Arg Leu Ile Gln Pro Pro Gly Asp Pro 
     210                215                220
Arg Gly Gly Arg Glu Gly Gln Arg Gln Glu Val Ile Phe Tyr Leu Ile 
 225                230                235                240
Ile Arg Arg Lys Pro Leu Phe Tyr Leu Val Asn Val Ile Ala Pro Cys 
                 245                250                255
Ile Leu Ile Thr Leu Leu Ala Ile Phe Val Phe Tyr Leu Pro Pro Asp 
             260                265                270
Ala Gly Glu Lys Met Gly Leu Ser Ile Phe Ala Leu Leu Thr Leu Thr 
         275                280                285
Val Phe Leu Leu Leu Leu Ala Asp Lys Val Pro Glu Thr Ser Leu Ser 
     290                295                300
Val Pro Ile Ile Ile Lys Tyr Leu Met Phe Thr Met Val Leu Val Thr 
 305                310                315                320
Phe Ser Val Ile Leu Ser Val Val Val Leu Asn Leu His His Arg Ser 
                 325                330                335
Pro His Thr His Gln Met Pro Leu Trp Val Arg Gln Ile Phe Ile His 
             340                345                350
Lys Leu Pro Leu Tyr Leu Arg Leu Lys Arg Pro Lys Pro Glu Arg Asp 
         355                360                365
Leu Met Pro Glu Pro Pro His Cys Ser Ser Pro Gly Ser Gly Trp Gly 
     370                375                380
Arg Gly Thr Asp Glu Tyr Phe Ile Arg Lys Pro Pro Ser Asp Phe Leu 
 385                390                395                400
Phe Pro Lys Pro Asn Arg Phe Gln Pro Glu Leu Ser Ala Pro Asp Leu 
                 405                410                415
Arg Arg Phe Ile Asp Gly Pro Asn Arg Ala Val Ala Leu Leu Pro Glu 
             420                425                430
Leu Arg Glu Val Val Ser Ser Ile Ser Tyr Ile Ala Arg Gln Leu Gln 
         435                440                445
Glu Gln Glu Asp His Asp Ala Leu Lys Glu Asp Trp Gln Phe Val Ala 
     450                455                460
Met Val Val Asp Arg Leu Phe Leu Trp Thr Phe Ile Ile Phe Thr Ser 
 465                470                475                480
Val Gly Thr Leu Val Ile Phe Leu Asp Ala Thr Tyr His Leu Pro Pro 
                 485                490                495
Pro Asp Pro Phe Pro 
             500



<210> 5375
<211> 397
<212> DNA
<213> Rattus norvegicus
<308> AA891069
<400> 5375

gctgtggag  cgtactcac  gcagaccca  aaggaggag  agcacctgc  ttctgccac  60
ccgtagcct  ggccgccat  ctccgcacg  acgcgccgt  cacacacat  aggatgttc  120
ccggcttga  atcagtgtg  atagtctaa  ccctgaagg  cctgtcgaa  gatactctt  180
acacagcgg  ctgggaggc  ttgatagtt  gacttgatg  tccatttga  gagatggtg  240
ccaagtact  cgaagacca  gcagacatg  atcccattc  tgcctgaga  cttgaagtc  300
tcgattagc  ggactacca  gtctttgtt  gggtcactg  ggtcacttt  tcgaacaca  360
ttgagcaat  taatttcaa  ccaagctgt  tctgtat  397



<210> 5376
<211> 681
<212> PRT
<213> Rattus norvegicus
<308> NP_033300
<400> 5376

Met Ser Val Asn Ser Glu Lys Ser Ser Ser Ser Glu Arg Pro Glu Pro 
  1               5                  10                  15
Gln Gln Lys Ala Pro Leu Val Pro Pro Pro Pro Pro Pro Pro Pro Pro 
             20                  25                  30
Pro Pro Leu Pro Asp Pro Ala Pro Pro Glu Pro Glu Glu Glu Ile Leu 
         35                  40                  45
Gly Ser Asp Asp Glu Glu Gln Glu Asp Pro Ala Asp Tyr Cys Lys Gly 
     50                  55                  60
Gly Tyr His Pro Val Lys Ile Gly Asp Leu Phe Asn Gly Arg Tyr His 
 65                  70                  75                  80
Val Ile Arg Lys Leu Gly Trp Gly His Phe Ser Thr Val Trp Leu Cys 
                 85                  90                  95
Trp Asp Met Gln Gly Lys Arg Phe Val Ala Met Lys Val Val Lys Ser 
             100                105                110
Ala Gln His Tyr Thr Glu Thr Ala Leu Asp Glu Ile Lys Leu Leu Lys 
         115                120                125
Cys Val Arg Glu Ser Asp Pro Ser Asp Pro Asn Lys Asp Met Val Val 
     130                135                140
Gln Leu Ile Asp Asp Phe Lys Ile Ser Gly Met Asn Gly Ile His Val 
 145                150                155                160
Cys Met Val Phe Glu Val Leu Gly His His Leu Leu Lys Trp Ile Ile 
                 165                170                175
Lys Ser Asn Tyr Gln Gly Leu Pro Val Arg Cys Val Lys Ser Ile Ile 
             180                185                190
Arg Gln Val Leu Gln Gly Leu Asp Tyr Leu His Ser Lys Cys Lys Ile 
         195                200                205
Ile His Thr Asp Ile Lys Pro Glu Asn Ile Leu Met Cys Val Asp Asp 
     210                215                220
Ala Tyr Val Arg Arg Met Ala Ala Glu Ala Thr Glu Trp Gln Lys Ala 
 225                230                235                240
Gly Ala Pro Pro Pro Ser Gly Ser Ala Val Ser Thr Ala Pro Gln Gln 
                 245                250                255
Lys Pro Ile Gly Lys Ile Ser Lys Asn Lys Lys Lys Lys Leu Lys Lys 
             260                265                270
Lys Gln Lys Arg Gln Ala Glu Leu Leu Glu Lys Arg Leu Gln Glu Ile 
         275                280                285
Glu Glu Leu Glu Arg Glu Ala Glu Arg Lys Ile Leu Glu Glu Asn Ile 
     290                295                300
Thr Ser Ala Glu Ala Ser Gly Glu Gln Asp Gly Glu Tyr Gln Pro Glu 
 305                310                315                320
Val Thr Leu Lys Ala Ala Asp Leu Glu Asp Thr Thr Glu Glu Glu Thr 
                 325                330                335
Ala Lys Asp Asn Gly Glu Val Glu Asp Gln Glu Glu Lys Glu Asp Ala 
             340                345                350
Glu Lys Glu Asn Ala Glu Lys Asp Glu Asp Asp Val Glu Gln Glu Pro 
         355                360                365
Ala Asn Leu Asp Pro Thr Trp Val Glu Ser Pro Lys Ala Asn Gly His 
     370                375                380
Ile Glu Asn Gly Pro Phe Ser Leu Glu Gln Gln Leu Glu Asp Glu Glu 
 385                390                395                400
Asp Asp Glu Asp Asp Cys Ala Asn Pro Glu Glu Tyr Asn Leu Asp Glu 
                 405                410                415
Pro Asn Ala Glu Ser Asp Tyr Thr Tyr Ser Ser Ser Tyr Glu Gln Phe 
             420                425                430
Asn Gly Glu Leu Pro Asn Gly Gln His Lys Thr Ser Glu Phe Pro Thr 
         435                440                445
Pro Leu Phe Ser Gly Pro Leu Glu Pro Val Ala Cys Gly Ser Val Ile 
     450                455                460
Ser Glu Gly Ser Pro Leu Thr Glu Gln Glu Glu Ser Ser Pro Ser His 
 465                470                475                480
Asp Arg Ser Arg Thr Val Ser Ala Ser Ser Thr Gly Asp Leu Pro Lys 
                 485                490                495
Thr Lys Thr Arg Ala Ala Asp Leu Leu Val Asn Pro Leu Asp Pro Arg 
             500                505                510
Asn Ala Asp Lys Ile Arg Val Lys Ile Ala Asp Leu Gly Asn Ala Cys 
         515                520                525
Trp Val His Lys His Phe Thr Glu Asp Ile Gln Thr Arg Gln Tyr Arg 
     530                535                540
Ser Ile Glu Val Leu Ile Gly Ala Gly Tyr Ser Thr Pro Ala Asp Ile 
 545                550                555                560
Trp Ser Thr Ala Cys Met Ala Phe Glu Leu Ala Thr Gly Asp Tyr Leu 
                 565                570                575
Phe Glu Pro His Ser Gly Glu Asp Tyr Ser Arg Asp Glu Asp His Ile 
             580                585                590
Ala His Ile Ile Glu Leu Leu Gly Ser Ile Pro Arg His Phe Ala Leu 
         595                600                605
Ser Gly Lys Tyr Ser Arg Glu Phe Phe Asn Arg Arg Gly Glu Leu Arg 
     610                615                620
His Ile Thr Lys Leu Lys Pro Trp Ser Leu Phe Asp Val Leu Val Glu 
 625                630                635                640
Lys Tyr Gly Trp Pro His Glu Asp Ala Ala Gln Phe Thr Asp Phe Leu 
                 645                650                655
Ile Pro Met Leu Glu Met Val Pro Glu Lys Arg Ala Ser Ala Gly Glu 
             660                665                670
Cys Leu Arg His Pro Trp Leu Asn Ser 
         675                680



<210> 5377
<211> 348
<212> DNA
<213> Rattus norvegicus
<308> AA891107
<400> 5377

aaaagagtt  aaagcatct  aaatacatg  aaattattt  aaacccctg  atggcaaat  60
tagagtctg  cagcagcag  cagatgtgt  agaagtaaa  aagcctctc  ccctctgac  120
tgtgccatg  cacggtggg  gaggggccc  agctctcta  cttatactg  atggcaccc  180
agagggtgg  gcggtagtc  caaacaagg  attgttatc  gggagggaa  ggaccgtgg  240
attcccgtt  gtcggagaa  accccagct  cagcctttg  aggtactct  cgtggacag  300
catgttgca  tgaagaacc  tgattgcgt  ttccacttt  aagcattc  348



<210> 5378
<211> 179
<212> PRT
<213> Rattus norvegicus
<308> AAK29279
<400> 5378

Met Lys Phe Lys Pro Asn Gln Thr Arg Thr Tyr Asp Arg Glu Gly Phe 
  1               5                  10                  15
Lys Lys Arg Ala Ala Cys Leu Cys Phe Arg Ser Glu Gln Glu Asp Glu 
             20                  25                  30
Val Leu Leu Val Ser Ser Ser Arg Tyr Pro Asp Gln Trp Ile Val Pro 
         35                  40                  45
Gly Gly Gly Val Glu Pro Glu Glu Glu Pro Gly Gly Ala Ala Ala Arg 
     50                  55                  60
Glu Val Tyr Glu Glu Ala Gly Val Lys Gly Lys Leu Gly Arg Leu Leu 
 65                  70                  75                  80
Gly Ile Phe Glu Asn Gln Asp Arg Lys His Arg Thr Tyr Val Tyr Val 
                 85                  90                  95
Leu Thr Val Thr Glu Ile Leu Glu Asp Trp Glu Asp Ser Val Asn Ile 
             100                105                110
Gly Arg Lys Arg Glu Trp Phe Lys Val Glu Asp Ala Ile Lys Val Leu 
         115                120                125
Gln Cys His Lys Pro Val His Ala Glu Tyr Leu Glu Arg Leu Lys Leu 
     130                135                140
Gly Cys Ser Pro Thr Asn Gly Asn Ser Thr Val Pro Ser Leu Pro Asp 
 145                150                155                160
Asn Asn Ala Leu Phe Val Thr Ala Ala Pro Pro Ser Gly Val Pro Ser 
                 165                170                175
Ser Ile Arg 
             180



<210> 5379
<211> 476
<212> DNA
<213> Homo sapiens
<308> AA287829
<400> 5379

gtacagagg  tacatattc  gggtgttct  ttataaagg  aacatttta  atcccacaa  60
ttgacactt  ctatcttca  tggactaag  tttttttgg  cagtaatct  tgaaatttc  120
ttaaattat  tacttaaca  agcagagaa  ctggattgt  tttgtatat  agactgctt  180
cacctgaaa  gctgtcata  gtactgggg  ggtggggga  tgcccatct  gtacatgat  240
ttcttagag  taataaggt  atgatgcat  aatttattt  ataaactct  ggactatgt  300
tttgacatg  aaaatatgt  cagtattaa  gtcaaccat  tctttaaag  tagcctata  360
atattgttg  ataattttc  ttggtcaga  acacttgga  tgaatagtg  cactcggta  420
ggattttca  tgccattta  caaaacgtc  ttagtctat  caactagca  aaatct  476



<210> 5380
<211> 180
<212> PRT
<213> Homo sapiens
<308> NP_061967
<400> 5380

Met Met Lys Phe Lys Pro Asn Gln Thr Arg Thr Tyr Asp Arg Glu Gly 
  1               5                  10                  15
Phe Lys Lys Arg Ala Ala Cys Leu Cys Phe Arg Ser Glu Gln Glu Asp 
             20                  25                  30
Glu Val Leu Leu Val Ser Ser Ser Arg Tyr Pro Asp Gln Trp Ile Val 
         35                  40                  45
Pro Gly Gly Gly Met Glu Pro Glu Glu Glu Pro Gly Gly Ala Ala Val 
     50                  55                  60
Arg Glu Val Tyr Glu Glu Ala Gly Val Lys Gly Lys Leu Gly Arg Leu 
 65                  70                  75                  80
Leu Gly Ile Phe Glu Asn Gln Asp Arg Lys His Arg Thr Tyr Val Tyr 
                 85                  90                  95
Val Leu Thr Val Thr Glu Ile Leu Glu Asp Trp Glu Asp Ser Val Asn 
             100                105                110
Ile Gly Arg Lys Arg Glu Trp Phe Lys Val Glu Asp Ala Ile Lys Val 
         115                120                125
Leu Gln Cys His Lys Pro Val His Ala Glu Tyr Leu Glu Lys Leu Lys 
     130                135                140
Leu Gly Cys Ser Pro Ala Asn Gly Asn Ser Thr Val Pro Ser Leu Pro 
 145                150                155                160
Asp Asn Asn Ala Leu Phe Val Thr Ala Ala Gln Thr Ser Gly Leu Pro 
                 165                170                175
Ser Ser Val Arg 
             180



<210> 5381
<211> 457
<212> DNA
<213> Rattus norvegicus
<308> AA891132
<400> 5381

aaaaaagga  aaaatatat  tcaatagta  aaccggcac  agaaacatc  ttttgttgt  60
agagaggca  gttagcacg  tgcttcctc  ttaacagtg  tccgacctt  acaaagtga  120
tcccagtcg  ggagcctcg  cacataacg  gatgttaac  tacgcccag  actacgtta  180
tggttagtc  aatctggca  gtatgtaat  acattagga  cattatgcc  ggacacaac  240
acaaacatt  atataaaaa  gtaaactcc  cgggagtga  ctgtggttt  cccccttgg  300
ttggatgac  aatatttta  acattaaag  catggtagt  tttgcattt  catgtgctg  360
gtcacacag  aaactcaga  tgctgtctc  aatctacag  ggttatcct  accatggtg  420
tgtgacttg  cagtgtgca  gaacatgcc  ctaatgg  457



<210> 5382
<211> 497
<212> PRT
<213> Rattus norvegicus
<308> Q62698
<400> 5382

Met Ala Pro Val Gly Val Glu Lys Lys Leu Leu Leu Gly Pro Asn Gly 
  1               5                  10                  15
Pro Ala Val Ala Ala Ala Gly Asp Leu Thr Ser Glu Glu Glu Glu Gly 
             20                  25                  30
Gln Ser Leu Trp Ser Ser Ile Leu Ser Glu Val Ser Thr Arg Ala Arg 
         35                  40                  45
Ser Lys Leu Pro Ser Gly Lys Asn Ile Leu Val Phe Gly Glu Asp Gly 
     50                  55                  60
Ser Gly Lys Thr Thr Leu Met Thr Lys Leu Gln Gly Ala Glu His Gly 
 65                  70                  75                  80
Lys Lys Gly Arg Gly Leu Glu Tyr Leu Tyr Leu Ser Val His Asp Glu 
                 85                  90                  95
Asp Arg Asp Asp His Thr Arg Cys Asn Val Trp Ile Leu Asp Gly Asp 
             100                105                110
Leu Tyr His Lys Gly Leu Leu Lys Phe Ala Val Ser Ala Glu Ser Leu 
         115                120                125
Arg Glu Thr Leu Val Ile Phe Val Ala Asp Met Ser Arg Pro Trp Thr 
     130                135                140
Ile Met Glu Ser Leu Gln Lys Trp Ala Ser Val Leu Arg Glu His Ile 
 145                150                155                160
Asp Lys Met Lys Ile Pro Pro Glu Glu Met Arg Asp Leu Glu Arg Lys 
                 165                170                175
Phe Met Lys Asp Phe Gln Asp Tyr Ile Glu Pro Glu Glu Gly Cys Gln 
             180                185                190
Gly Ser Pro Gln Arg Arg Gly Pro Leu Thr Ser Gly Ser Asp Glu Asp 
         195                200                205
Asn Val Ala Leu Pro Leu Gly Asp Asn Val Leu Thr His Asn Leu Gly 
     210                215                220
Ile Pro Val Leu Val Val Cys Thr Lys Cys Asp Ala Val Ser Ile Leu 
 225                230                235                240
Glu Lys Glu His Asp Tyr Arg Asp Glu His Leu Asp Phe Ile Gln Ala 
                 245                250                255
His Leu Arg Gly Phe Cys Leu Gln Tyr Gly Ala Ala Leu Ile Tyr Thr 
             260                265                270
Ser Val Lys Glu Glu Lys Asn Leu Asp Leu Leu Tyr Lys Tyr Ile Val 
         275                280                285
His Lys Thr Tyr Gly Phe His Phe Thr Ile Pro Ala Leu Val Val Glu 
     290                295                300
Lys Asp Ala Val Phe Ile Pro Ala Gly Trp Asp Asn Glu Lys Lys Ile 
 305                310                315                320
Ala Ile Leu His Glu Asn Phe Thr Thr Val Lys Pro Glu Asp Ala Tyr 
                 325                330                335
Glu Asp Phe Ile Val Lys Pro Pro Val Arg Lys Leu Val His Asp Lys 
             340                345                350
Glu Leu Ala Ala Glu Asp Glu Gln Val Phe Leu Met Lys Gln Gln Glu 
         355                360                365
Ser Pro Ala Arg Gly Pro Ser Gly Ser Pro Arg Thr Gln Gly Arg Gly 
     370                375                380
Gly Pro Ala Ser Val Pro Ser Ala Ser Pro Gly Thr Ser Val Lys Lys 
 385                390                395                400
Pro Asp Pro Asn Ile Lys Asn Asn Ala Ala Ser Glu Gly Val Leu Ala 
                 405                410                415
Ser Phe Phe Asn Ser Leu Leu Ser Lys Lys Thr Gly Ser Pro Gly Ser 
             420                425                430
Pro Ser Ala Gly Gly Val Gln Ser Thr Ala Lys Lys Ser Gly Thr Glu 
         435                440                445
Gly Glu Pro Gln Ser Phe Arg Ser Leu Thr Glu Gln Cys Cys Gln Thr 
     450                455                460
Gly Gln Lys Thr Val Leu Ser Asn Val Gln Glu Glu Leu Asp Arg Met 
 465                470                475                480
Thr Arg Lys Pro Asp Ser Met Val Thr Asn Ser Ser Thr Glu Asn Glu 
                 485                490                495
Ala 
             500



<210> 5383
<211> 1622
<212> DNA
<213> Homo sapiens
<308> AF035812
<400> 5383

ggcaagatg  cgccggtgg  ggtggagaa  aagctgctg  taggtccca  cgggcccgc  60
gtggcggcc  ccggcgacc  gaccagtga  gaggaggaa  gccagagcc  atggtcctc  120
attctgagc  aagtgtcca  ccgcgccag  tccaagctg  cgtccggca  gaacatcct  180
gtcttcggt  aagatggtt  tggtaaaac  accctcatg  ctaaactac  aggagctga  240
catggcaaa  aaggaagag  cctagaata  ctctacctc  gtgtccatg  tgaggaccg  300
gatgatcac  cgcgctgca  cgtgtggat  ctggatgga  acttgtacc  caaaggcct  360
ctgaaattt  cagtttctg  tgaatcctt  ccagagacc  tcgtcattt  tgttgcaga  420
atgtctaga  cttggactg  gatggaatc  ctgcagaaa  gggctagtg  tttacgtga  480
cacattgat  aaatgaaaa  tccaccaga  aaaatgagg  agctggaac  gaagtttgt  540
aaagatttt  aagactata  ggaacctga  gaaggttgt  aaggttccc  acagagaag  600
ggccctctg  cctcaggct  cgatgaaga  aatgttgcc  tgcctctgg  tgacaatgt  660
ctgactcat  acctgggga  cccggtgtt  gtggtgtgc  caaagtgtg  tgcggtgag  720
gtcctggag  aggagcacg  ttacaggga  gagcatttg  actttatcc  gtcacacct  780
cggaggttc  gccttcagt  tggagctgc  ttgatttac  catcagtga  agaagagaa  840
aacctcgac  tgttgtata  gtatattgt  cataaaaca  acggtttcc  cttcaccac  900
cctgcctta  ttgtggaaa  ggatgccgt  tttatacct  caggctggg  caatgaaaa  960
aaaatagct  ttttacatg  aaattttac  accgtgaag  cggaagatg  atatgaaga  1020
tttattgtg  aacctcccg  gagaaagct  gtccacgac  aagagttgg  agcagaaga  1080
gagcaggtg  tcctaatga  gcaacagtc  ctccttgcc  agcaaccag  cactcccac  1140
agagcttct  aatctcctg  aagaggacc  tctggctct  caaggaccc  gggtcgggg  1200
gggccagcc  gtgtgccta  ctcctcccc  ggcacgtca  taaaaaagc  ggacccaaa  1260
atcaaaaat  atgcagcaa  tgaaggggt  ttggccagc  tcttcaaca  tctgttgag  1320
aaaaagaca  gctctcctg  aagtcctgg  gctggtggg  tgcagagca  agccaagaa  1380
tcaggacaa  agactgtgt  gtcaaatgt  caggaagaa  tggatagaa  gactcgaaa  1440
ccagactct  tggtaacaa  ctcttcaac  gaaaatgaa  cctgaacct  cttaaaaag  1500
gcatatgtc  aatgaccaa  taactatgt  tattgatct  ctaagacca  gatttttct  1560
atatggcac  tgctatcag  tttttgggg  aggggagat  aactttaaa  aaaaaaaaa  1620
aa  1622



<210> 5384
<211> 492
<212> PRT
<213> Homo sapiens
<308> O43237
<400> 5384

Met Ala Pro Val Gly Val Glu Lys Lys Leu Leu Leu Gly Pro Asn Gly 
  1               5                  10                  15
Pro Ala Val Ala Ala Ala Gly Asp Leu Thr Ser Glu Glu Glu Glu Gly 
             20                  25                  30
Gln Ser Leu Trp Ser Ser Ile Leu Ser Glu Val Ser Thr Arg Ala Arg 
         35                  40                  45
Ser Lys Leu Pro Ser Gly Lys Asn Ile Leu Val Phe Gly Glu Asp Gly 
     50                  55                  60
Ser Gly Lys Thr Thr Leu Met Thr Lys Leu Gln Gly Ala Glu His Gly 
 65                  70                  75                  80
Lys Lys Gly Arg Gly Leu Glu Tyr Leu Tyr Leu Ser Val His Asp Glu 
                 85                  90                  95
Asp Arg Asp Asp His Thr Arg Cys Asn Val Trp Ile Leu Asp Gly Asp 
             100                105                110
Leu Tyr His Lys Gly Leu Leu Lys Phe Ala Val Ser Ala Glu Ser Leu 
         115                120                125
Pro Glu Thr Leu Val Ile Phe Val Ala Asp Met Ser Arg Pro Trp Thr 
     130                135                140
Val Met Glu Ser Leu Gln Lys Trp Ala Ser Val Leu Arg Glu His Ile 
 145                150                155                160
Asp Lys Met Lys Ile Pro Pro Glu Lys Met Arg Glu Leu Glu Arg Lys 
                 165                170                175
Phe Val Lys Asp Phe Gln Asp Tyr Met Glu Pro Glu Glu Gly Cys Gln 
             180                185                190
Gly Ser Pro Gln Arg Arg Gly Pro Leu Thr Ser Gly Ser Asp Glu Glu 
         195                200                205
Asn Val Ala Leu Pro Leu Gly Asp Asn Val Leu Thr His Asn Leu Gly 
     210                215                220
Ile Pro Val Leu Val Val Cys Thr Lys Cys Asp Ala Val Ser Val Leu 
 225                230                235                240
Glu Lys Glu His Asp Tyr Arg Asp Glu His Leu Asp Phe Ile Gln Ser 
                 245                250                255
His Leu Arg Arg Phe Cys Leu Gln Tyr Gly Ala Ala Leu Ile Tyr Thr 
             260                265                270
Ser Val Lys Glu Glu Lys Asn Leu Asp Leu Leu Tyr Lys Tyr Ile Val 
         275                280                285
His Lys Thr Tyr Gly Phe His Phe Thr Thr Pro Ala Leu Val Val Glu 
     290                295                300
Lys Asp Ala Val Phe Ile Pro Ala Gly Trp Asp Asn Glu Lys Lys Ile 
 305                310                315                320
Ala Ile Leu His Glu Asn Phe Thr Thr Val Lys Pro Glu Asp Ala Tyr 
                 325                330                335
Glu Asp Phe Ile Val Lys Pro Pro Val Arg Lys Leu Val His Asp Lys 
             340                345                350
Glu Leu Ala Ala Glu Asp Glu Gln Val Phe Leu Met Lys Gln Gln Ser 
         355                360                365
Leu Leu Ala Lys Gln Pro Ala Thr Pro Thr Arg Ala Ser Glu Ser Pro 
     370                375                380
Ala Arg Gly Pro Ser Gly Ser Pro Arg Thr Gln Gly Arg Gly Gly Pro 
 385                390                395                400
Ala Ser Val Pro Ser Ser Ser Pro Gly Thr Ser Val Lys Lys Pro Asp 
                 405                410                415
Pro Asn Ile Lys Asn Asn Ala Ala Ser Glu Gly Val Leu Ala Ser Phe 
             420                425                430
Phe Asn Ser Leu Leu Ser Lys Lys Thr Gly Ser Pro Gly Ser Pro Gly 
         435                440                445
Ala Gly Gly Val Gln Ser Thr Ala Lys Lys Ser Gly Gln Lys Thr Val 
     450                455                460
Leu Ser Asn Val Gln Glu Glu Leu Asp Arg Met Thr Arg Lys Pro Asp 
 465                470                475                480
Ser Met Val Thr Asn Ser Ser Thr Glu Asn Glu Ala 
                 485                490



<210> 5385
<211> 474
<212> DNA
<213> Rattus norvegicus
<308> AA891161
<400> 5385

gcagaaaca  gtgttttaa  tcatggttt  gattctggt  ggtacaaca  caaattatt  60
ggaattctg  tcagaaaac  caaagctgc  cctgtagat  ttatttcaa  taaaggaca  120
gtgaattta  gtacttggt  tgtagcaag  aatttccat  atggtgtgt  cctggtctg  180
gcacacctt  tggtgacta  ctatggctt  tgcaggaac  tcagtctgc  cactgctga  240
aagcctact  tgaactgtt  tcaggtgtc  agctgaggg  aatgctgag  aagaccagc  300
cagttgtct  tccttatac  ccatggcac  tangcaggg  caagaaaca  ggcacagca  360
ttcatacac  aaatacagg  agccaacat  tgacttgtc  agtttcaga  ttgatatca  420
gttgtttgg  tgatcctcc  cataattca  aacaggaag  gtactgcac  ttga  474



<210> 5386
<211> 2533
<212> DNA
<213> Homo sapiens
<308> AK001865
<400> 5386

ttatcaatg  tttttaatg  gtttttacc  ttgcctcac  gtgtgtgtg  cactttcta  60
aatataaag  aatactata  tatttctag  gtctggaac  gtcaccatg  tgaatggcc  120
tttcaatgc  tagttacag  aattcctga  gattcccca  gacttcaat  tcattggtt  180
ttatttgca  tttttagtt  ctgtaattg  tgctgtttc  agtctaaag  acctccttt  240
gtaaaggtg  acaagacct  tcccctatg  tacccagcc  gattttgtg  gtgtaatgg  300
ctggcccaa  agtgttctt  tacttagaa  tccttttga  tttgctttt  tctgcccct  360
gaaatttta  ggacaaaga  attttggaa  ttgtcagtt  cttttagaa  gaaaacact  420
cagaaatat  taacagatt  cttcttgat  aaatttaaa  gggattata  gaatttata  480
tgccaattg  aaatattat  tacacaaaa  ttgctattt  cacttaaag  aagcatttt  540
aaaggattt  ttttagaat  caatctatg  aatcctcga  ctcagtgtg  ttttccctg  600
caggatata  aaaaaggta  attaggtca  ccctccttt  agcttactc  cccctcacc  660
tttcttttc  ctgtatata  acggtactt  ctgtgattc  taccaacag  ggactttct  720
tgattcata  caacagtcc  aaactgtca  tttctaaat  tgggattta  aatctttag  780
caatattta  aatcttgat  ttttttaaa  gtcagcaga  acaatttgg  agattgcat  840
tgtgtagaa  taatgcagg  acaagatct  gagtttttc  ttagactct  tagtctttt  900
tgaattaaa  aataagtgc  cttaaatcc  tattttatc  tgtcaaagt  tgaaatgtg  960
tcattgatg  tttggtgac  tctaaaaaa  tgtatttag  tggcttggc  cacccctct  1020
aaaaatact  agccatctc  tggtgggat  tggtggggg  attaaggtc  cagagttat  1080
tattttctc  cctaatttc  aacctttat  aacttgggg  tttgttgtt  atggtggta  1140
tattttttg  taagttgtt  aaaaggctg  cttgattgg  gcctcctct  ctttttctt  1200
agggttgca  gtattgtat  gtgggggag  ggggcctta  ggcaaactg  ctaaaaagt  1260
actatccaa  taatttaac  agtaaatta  taagaatta  tcttagtat  cattcagag  1320
ttaagatgt  aaaaatctg  actttgttt  tcactctaa  tgtaaagaa  tttttgata  1380
tgttatttc  ccactccct  agttaaagg  tattattta  actgtttac  ggagaaaat  1440
ctcgctcat  tccatttat  gtttttttc  gtactgtga  ttgtttcaa  cttaggaaa  1500
ctagtatat  agagtatgt  ctaggaaat  aaaagatct  gttagagta  aaagttctt  1560
ttaaggttc  taactaatt  tttcacaac  aagaaaata  atgaagtat  cttaggctg  1620
aattcatct  attttatca  aaattagat  gtaggggca  cctacattt  tgtgtatgt  1680
tttttattt  ttaaatgat  gtgtgagcc  ggtgacttt  tatggttct  gtgatctaa  1740
ctgtttttc  aattcacat  ttttgtcgt  aagtgatat  atactagag  actgtttgc  1800
ttgtaaaaa  gctttgctg  tgctctggc  ttttgtctt  atctcatca  ctaatttaa  1860
aacccagca  ttgataata  aactgacag  aatgattgt  cccactgat  aagtaatga  1920
aatgaagaa  aggaaaata  tccttcctt  aatggcgta  gtttatttt  tacttaagt  1980
gcatctatg  aagttagac  aactatata  taaaattgg  aaactttga  tgtttctcc  2040
gttttgatt  ttagattat  aggaggatc  gacagaata  gactccaca  ttttgaaat  2100
tgataagtc  aaacgtttt  ttttgacat  tttaacatt  tgaattatt  gatatttgt  2160
atctctgta  gtatatgaa  ctctgccat  tttttcaac  ttgcctatg  gccactgta  2220
ataagaaag  acagctatt  tgatcttca  cagcattgc  ttcagctga  aatttggga  2280
cagttcaca  taaacctct  agtagtttg  aaactgagg  acctgcaga  accatagct  2340
ctcaccaaa  tacacagat  aggtgcatg  tatcgtgga  attatttgg  aaaaaaaca  2400
acacacaaa  ctatgtgta  tgtatttta  ggaatatct  caggtgcag  tttgatttt  2460
aacagaatt  caaataatt  actgttgta  ccaccagaa  ctagaaaat  tgaattaaa  2520
tacatgttt  tgc  2533



<210> 5387
<211> 474
<212> DNA
<213> Rattus norvegicus
<308> AA891161
<400> 5387

gcagaaaca  gtgttttaa  tcatggttt  gattctggt  ggtacaaca  caaattatt  60
ggaattctg  tcagaaaac  caaagctgc  cctgtagat  ttatttcaa  taaaggaca  120
gtgaattta  gtacttggt  tgtagcaag  aatttccat  atggtgtgt  cctggtctg  180
gcacacctt  tggtgacta  ctatggctt  tgcaggaac  tcagtctgc  cactgctga  240
aagcctact  tgaactgtt  tcaggtgtc  agctgaggg  aatgctgag  aagaccagc  300
cagttgtct  tccttatac  ccatggcac  tangcaggg  caagaaaca  ggcacagca  360
ttcatacac  aaatacagg  agccaacat  tgacttgtc  agtttcaga  ttgatatca  420
gttgtttgg  tgatcctcc  cataattca  aacaggaag  gtactgcac  ttga  474



<210> 5388
<211> 2533
<212> DNA
<213> Homo sapiens
<308> AK001865
<400> 5388

ttatcaatg  tttttaatg  gtttttacc  ttgcctcac  gtgtgtgtg  cactttcta  60
aatataaag  aatactata  tatttctag  gtctggaac  gtcaccatg  tgaatggcc  120
tttcaatgc  tagttacag  aattcctga  gattcccca  gacttcaat  tcattggtt  180
ttatttgca  tttttagtt  ctgtaattg  tgctgtttc  agtctaaag  acctccttt  240
gtaaaggtg  acaagacct  tcccctatg  tacccagcc  gattttgtg  gtgtaatgg  300
ctggcccaa  agtgttctt  tacttagaa  tccttttga  tttgctttt  tctgcccct  360
gaaatttta  ggacaaaga  attttggaa  ttgtcagtt  cttttagaa  gaaaacact  420
cagaaatat  taacagatt  cttcttgat  aaatttaaa  gggattata  gaatttata  480
tgccaattg  aaatattat  tacacaaaa  ttgctattt  cacttaaag  aagcatttt  540
aaaggattt  ttttagaat  caatctatg  aatcctcga  ctcagtgtg  ttttccctg  600
caggatata  aaaaaggta  attaggtca  ccctccttt  agcttactc  cccctcacc  660
tttcttttc  ctgtatata  acggtactt  ctgtgattc  taccaacag  ggactttct  720
tgattcata  caacagtcc  aaactgtca  tttctaaat  tgggattta  aatctttag  780
caatattta  aatcttgat  ttttttaaa  gtcagcaga  acaatttgg  agattgcat  840
tgtgtagaa  taatgcagg  acaagatct  gagtttttc  ttagactct  tagtctttt  900
tgaattaaa  aataagtgc  cttaaatcc  tattttatc  tgtcaaagt  tgaaatgtg  960
tcattgatg  tttggtgac  tctaaaaaa  tgtatttag  tggcttggc  cacccctct  1020
aaaaatact  agccatctc  tggtgggat  tggtggggg  attaaggtc  cagagttat  1080
tattttctc  cctaatttc  aacctttat  aacttgggg  tttgttgtt  atggtggta  1140
tattttttg  taagttgtt  aaaaggctg  cttgattgg  gcctcctct  ctttttctt  1200
agggttgca  gtattgtat  gtgggggag  ggggcctta  ggcaaactg  ctaaaaagt  1260
actatccaa  taatttaac  agtaaatta  taagaatta  tcttagtat  cattcagag  1320
ttaagatgt  aaaaatctg  actttgttt  tcactctaa  tgtaaagaa  tttttgata  1380
tgttatttc  ccactccct  agttaaagg  tattattta  actgtttac  ggagaaaat  1440
ctcgctcat  tccatttat  gtttttttc  gtactgtga  ttgtttcaa  cttaggaaa  1500
ctagtatat  agagtatgt  ctaggaaat  aaaagatct  gttagagta  aaagttctt  1560
ttaaggttc  taactaatt  tttcacaac  aagaaaata  atgaagtat  cttaggctg  1620
aattcatct  attttatca  aaattagat  gtaggggca  cctacattt  tgtgtatgt  1680
tttttattt  ttaaatgat  gtgtgagcc  ggtgacttt  tatggttct  gtgatctaa  1740
ctgtttttc  aattcacat  ttttgtcgt  aagtgatat  atactagag  actgtttgc  1800
ttgtaaaaa  gctttgctg  tgctctggc  ttttgtctt  atctcatca  ctaatttaa  1860
aacccagca  ttgataata  aactgacag  aatgattgt  cccactgat  aagtaatga  1920
aatgaagaa  aggaaaata  tccttcctt  aatggcgta  gtttatttt  tacttaagt  1980
gcatctatg  aagttagac  aactatata  taaaattgg  aaactttga  tgtttctcc  2040
gttttgatt  ttagattat  aggaggatc  gacagaata  gactccaca  ttttgaaat  2100
tgataagtc  aaacgtttt  ttttgacat  tttaacatt  tgaattatt  gatatttgt  2160
atctctgta  gtatatgaa  ctctgccat  tttttcaac  ttgcctatg  gccactgta  2220
ataagaaag  acagctatt  tgatcttca  cagcattgc  ttcagctga  aatttggga  2280
cagttcaca  taaacctct  agtagtttg  aaactgagg  acctgcaga  accatagct  2340
ctcaccaaa  tacacagat  aggtgcatg  tatcgtgga  attatttgg  aaaaaaaca  2400
acacacaaa  ctatgtgta  tgtatttta  ggaatatct  caggtgcag  tttgatttt  2460
aacagaatt  caaataatt  actgttgta  ccaccagaa  ctagaaaat  tgaattaaa  2520
tacatgttt  tgc  2533



<210> 5389
<211> 592
<212> DNA
<213> Rattus norvegicus
<308> AA891171
<400> 5389

acaggtgtt  acatattaa  ctaaacttc  ctgtcacag  aagacatcc  ataaaattc  60
gaaaatatt  aggttgtgg  gaggaagat  aagcctttt  aagacttca  cgcactgga  120
ggaatggct  aagaatttc  gcataagtt  tcttctctt  ctcaggaaa  tcttctgga  180
gtaatttta  atacccgaa  atgtcatgg  ccctcacag  atacagata  ttttgacgt  240
ttaaataaa  atatccagc  aagaaaaag  aagtaacat  cagaagctg  cgatgcaaa  300
cttagtaga  aaccctgta  ctcctcctc  gggtaggac  gcctcgcag  cctcacctg  360
tttcatcac  ggtctcatt  gcatcatgt  gtccatcag  cccgtgcag  agcccagga  420
gccgatgta  acaagccgc  ggtcgttca  cttgggcgg  ggcagtctc  gggcctcat  480
cggcaagaa  cttaagggc  catggcccg  ccggccgtt  atcatattg  tgcggggtt  540
acgtgaggt  tgacctcga  tccaactat  agaaaaacc  cgactacaa  cc  592



<210> 5390
<211> 120
<212> PRT
<213> Rattus norvegicus
<308> AAH02097
<400> 5390

Met Met Asn Gly Arg Pro Gly His Glu Pro Leu Lys Phe Leu Pro Asp 
  1               5                  10                  15
Glu Ala Arg Ser Leu Pro Pro Pro Lys Leu Asn Asp Pro Arg Leu Val 
             20                  25                  30
Tyr Met Gly Leu Leu Gly Tyr Cys Thr Gly Leu Met Asp Asn Met Leu 
         35                  40                  45
Arg Met Arg Pro Val Met Arg Ala Gly Leu His Arg Gln Leu Leu Phe 
     50                  55                  60
Val Thr Ser Phe Val Phe Ala Gly Tyr Phe Tyr Leu Lys Arg Gln Asn 
 65                  70                  75                  80
Tyr Leu Tyr Ala Val Lys Asp His Asp Met Phe Gly Tyr Ile Lys Leu 
                 85                  90                  95
His Pro Glu Asp Phe Pro Glu Lys Glu Lys Lys Thr Tyr Ala Glu Ile 
             100                105                110
Leu Glu Pro Phe His Pro Val Arg 
         115                120



<210> 5391
<211> 656
<212> DNA
<213> Homo sapiens
<308> BG723290
<400> 5391

agcgggagt  cggcgcgca  aggaggagg  gaaagctga  cgcttaggc  cgggtagtg  60
tcgtcgtgg  tttccttgt  gttcgtggt  tgagaccag  cctcaagtg  aaacggcgt  120
accatgatc  cacggcgga  cccagaacc  ttacggttt  tgccggatg  ggcccggag  180
ctgcccccg  ccaagctga  cgacccgcg  ctcctctac  tcggcttct  gggctactg  240
tccggcctg  ttgataacc  gatccggcg  aggccgatc  cgacggctg  tttgcatcg  300
cagcttcta  atattacgg  ctttttttt  gctggatat  atcttgtaa  acgtgaaga  360
tacctgtat  ctgtgaggg  ccgtgaaat  tttggatat  tgaaattac  tccagagga  420
tttcctgaa  aagatgtct  ctgttgtgg  gctgaacgt  gggggtgag  tccacacca  480
caccctggg  accctgagg  agtttccgg  ctcaaagct  gcagagatg  tctctagct  540
agccaaggc  tccacggac  cggagggcc  cttcttcat  gaccgccca  cacctattt  600
agacccatc  tggactacc  gcgcactgg  caagtgccc  cacagacat  cctgaa  656



<210> 5392
<211> 119
<212> PRT
<213> Homo sapiens
<308> O95298
<400> 5392

Met Ile Ala Arg Arg Asn Pro Glu Pro Leu Arg Phe Leu Pro Asp Glu 
  1               5                  10                  15
Ala Arg Ser Leu Pro Pro Pro Lys Leu Thr Asp Pro Arg Leu Leu Tyr 
             20                  25                  30
Ile Gly Phe Leu Gly Tyr Cys Ser Gly Leu Ile Asp Asn Leu Ile Arg 
         35                  40                  45
Arg Arg Pro Ile Ala Thr Ala Gly Leu His Arg Gln Leu Leu Tyr Ile 
     50                  55                  60
Thr Ala Phe Phe Phe Ala Gly Tyr Tyr Leu Val Lys Arg Glu Asp Tyr 
 65                  70                  75                  80
Leu Tyr Ala Val Arg Asp Arg Glu Met Phe Gly Tyr Met Lys Leu His 
                 85                  90                  95
Pro Glu Asp Phe Pro Glu Glu Asp Lys Lys Thr Tyr Gly Glu Ile Phe 
             100                105                110
Glu Lys Phe His Pro Ile Arg 
         115



<210> 5393
<211> 635
<212> DNA
<213> Rattus norvegicus
<308> AA891220
<400> 5393

aacatttca  taacagaac  aaactttat  tccatgttt  ttacatgtt  gtcttggat  60
ctgagtaca  attagaatt  acataacat  caacctggg  gaaagtctg  tattctcca  120
tgaatgagt  aaaaaggaa  gtaaaacta  aaaatacta  tttacgtgt  agttctaag  180
tatgattaa  acaacaaca  acatcttgc  atttttctc  aattttccg  ggtggattt  240
actataaaa  ctttttttt  tcatttcaa  aaaggaagg  ctactcata  aaaatcttt  300
agtataggg  acaaattag  ctcaacaca  aattctact  cctacctaa  agttatgaa  360
tgaggggac  aatgtcaac  gcaaatcta  tgtctgaaa  gttagtcta  tctaaggat  420
acacgcaaa  acaactcca  ttgtcattt  tgttaacca  ttggtactc  gaacggggt  480
gccaaacac  gcttagtga  agagatcca  catgaatct  ttccaaggg  accagagcc  540
agagggatg  ctcattcta  ctccggacc  acactgtac  caaacggaa  ctactagtt  600
acactacat  tttcaagac  aaattggca  gtgta  635



<210> 5394
<211> 627
<212> DNA
<213> Rattus norvegicus
<308> AA891221
<400> 5394

ggcatttca  atgctactg  tgtgagtag  atttatttt  agaaatgaa  gacagctga  60
acaaaatgt  tgcctccaa  aagtatgtc  tacttacaa  ggaaaaggt  attaatatt  120
aacattttc  ttgttcaac  gttctaatt  ttataaggg  tttataagt  tcatagtca  180
taagcaggt  ctttttgaa  ggtaggctt  atgacccat  tgacttcgt  cctttacat  240
acatgacaa  ttattttat  caaattatg  tttccaaaa  agagggttc  gtgctagtc  300
tctttgaaa  ttttcatac  atttcagaa  cacatttgc  gggatgaac  tttccgatg  360
atttggtgt  atctgggcc  gagagagag  aaatgatga  gcaaaattg  agaagttgt  420
caacatctt  tgtgtgaac  gtgtgaagg  gtcaaccga  gacacagcg  cactgccta  480
gggagtctg  tgagccaaa  tgtccaaca  ctccaccga  attccaatc  gggcaacag  540
tggggttcg  acaatattc  tggctccaa  tgggtgctg  cttccttct  cagatttaa  600
acctgatat  ttgaagatg  cacttgg  627



<210> 5395
<211> 197
<212> PRT
<213> Rattus norvegicus
<308> NP_080580
<400> 5395

Met Phe Gly Cys Leu Val Ala Gly Arg Leu Val Gln Thr Ala Ala Gln 
  1               5                  10                  15
Gln Val Ala Glu Asp Lys Phe Val Phe Asp Leu Pro Asp Tyr Glu Asn 
             20                  25                  30
Ile Asn His Val Val Val Phe Met Leu Gly Thr Ile Pro Phe Pro Glu 
         35                  40                  45
Gly Met Gly Gly Ser Val Tyr Phe Ser Tyr Pro Asp Ser Asn Gly Val 
     50                  55                  60
Pro Val Trp Gln Leu Leu Gly Phe Val Thr Asn Gly Lys Pro Ser Ala 
 65                  70                  75                  80
Ile Phe Lys Ile Ser Gly Leu Lys Ser Gly Glu Gly Ser Gln His Pro 
                 85                  90                  95
Phe Gly Ala Met Asn Ile Val Arg Thr Pro Ser Val Ala Gln Ile Gly 
             100                105                110
Ile Ser Val Glu Leu Leu Asp Ser Leu Ala Gln Gln Thr Pro Val Gly 
         115                120                125
Ser Ala Ala Val Ser Ser Val Asp Ser Phe Thr Gln Phe Thr Gln Lys 
     130                135                140
Met Leu Asp Asn Phe Tyr Asn Phe Ala Ser Ser Phe Ala Leu Ser Gln 
 145                150                155                160
Ala Gln Met Thr Pro Asn Pro Ser Glu Met Phe Ile Pro Ala Asn Val 
                 165                170                175
Val Leu Lys Trp Tyr Glu Asn Phe Gln Arg Arg Leu Ala Gln Asn Pro 
             180                185                190
Leu Phe Trp Lys Thr 
         195



<210> 5396
<211> 827
<212> DNA
<213> Homo sapiens
<308> AK001447
<400> 5396

gttgcctga  cagtgggct  cttaggaag  gaaggtcag  gttcgcggg  gcagaggca  60
tcttgccgc  ggcccagtc  ctatgtagt  gaggggcag  caccctccc  caaattctg  120
aaggttctt  gtctcgact  gggcagtag  cccaggact  ctagtcgcc  gcttcaggt  180
actgccggc  gaacggagc  gccgtcgcc  tgtttggct  cttggtggc  gggaggctg  240
tgcaaacag  tgcacagca  gtggcagag  ataaatttg  ttttgactt  cctgattat  300
aaagtatca  ccatgttgt  gtttttatg  tgggaacaa  cccatttcc  gagggaatg  360
gaggatctg  ctacttttc  tatcctgat  caaatggaa  gccagtatg  caactccta  420
gatttgtca  gaatgggaa  ccaagtgcc  tcttcaaaa  ttcaggtct  aaatctgga  480
aaggaagcc  acatccttt  ggagccatg  atattgtcc  aactccatc  gttgctcag  540
ttggaattt  agtggaatt  ttagacagt  tggctcagc  gactcctgt  ggtaatgct  600
ctgtatcct  agttgactc  ttcactcag  tcacacaaa  gatgttgga  aatttctac  660
attttgctt  atcatttgc  gtctctcag  cccagatga  accaagccc  tctgaaatg  720
tcattccgg  aaatgtggt  ctgaaatgg  atgaaaact  tcaaagacg  ctagcacag  780
accctctct  ttggaaaac  taatttgaa  aaaataatt  ttaatgg  827



<210> 5397
<211> 198
<212> PRT
<213> Homo sapiens
<308> AK001447
<400> 5397

Met Phe Gly Cys Leu Val Ala Gly Arg Leu Val Gln Thr Ala Ala Gln 
  1               5                  10                  15
Gln Val Ala Glu Asp Lys Phe Val Phe Asp Leu Pro Asp Tyr Glu Ser 
             20                  25                  30
Ile Asn His Val Val Val Phe Met Leu Gly Thr Ile Pro Phe Pro Glu 
         35                  40                  45
Gly Met Gly Gly Ser Val Tyr Phe Ser Tyr Pro Asp Ser Asn Gly Met 
     50                  55                  60
Pro Val Trp Gln Leu Leu Gly Phe Val Thr Asn Gly Lys Pro Ser Ala 
 65                  70                  75                  80
Ile Phe Lys Ile Ser Gly Leu Lys Ser Gly Glu Gly Ser Gln His Pro 
                 85                  90                  95
Phe Gly Ala Met Asn Ile Val Arg Thr Pro Ser Val Ala Gln Ile Gly 
             100                105                110
Ile Ser Val Glu Leu Leu Asp Ser Met Ala Gln Gln Thr Pro Val Gly 
         115                120                125
Asn Ala Ala Val Ser Ser Val Asp Ser Phe Thr Gln Phe Thr Gln Lys 
     130                135                140
Met Leu Asp Asn Phe Tyr Asn Phe Ala Ser Ser Phe Ala Val Ser Gln 
 145                150                155                160
Ala Gln Met Thr Pro Ser Pro Ser Glu Met Phe Ile Pro Ala Asn Val 
                 165                170                175
Val Leu Lys Trp Tyr Glu Asn Phe Gln Arg Arg Leu Ala Gln Asn Pro 
             180                185                190
Leu Phe Trp Lys Thr Ter 
         195



<210> 5398
<211> 474
<212> DNA
<213> Rattus norvegicus
<308> AA891286
<400> 5398

gatcaacac  ttttattgg  tcacatttt  tttccagaa  aactgtaat  aaaatacat  60
gaattggaa  ttgggttac  gtacattgt  cgattacag  acataaacg  cgaagtgta  120
tccttccat  ggggcggaa  atttcatcc  accaataga  tcacaacat  attaggcgg  180
taccctaca  tgtcgttct  atctcagag  ctggcagac  taggagaaa  aaaaacaaa  240
aataaataa  taaaactca  cagtccact  ctttggttc  ctggtcttt  ctcctcttc  300
acacacgga  gtggggcgg  tctgaggga  cctcgtggg  caaggtggg  gccgctggc  360
gaataccag  caaacccgt  ccctgaggt  gccccacaa  gtactggga  acgccactc  420
gtactgcag  tggagatgg  cagaaggga  gacaagaaa  ctcgtgccg  attc  474



<210> 5399
<211> 496
<212> PRT
<213> Rattus norvegicus
<308> AAD43039
<400> 5399

Met Asn Asp Ser Lys Asp Ala Pro Lys Ser Tyr Asp Phe Asp Leu Ile 
  1               5                  10                  15
Ile Ile Gly Gly Gly Ser Gly Gly Leu Ala Ala Ala Lys Glu Ala Ala 
             20                  25                  30
Lys Phe Asp Lys Lys Val Met Val Leu Asp Phe Val Thr Pro Thr Pro 
         35                  40                  45
Leu Gly Thr Asn Gly Gly Leu Gly Gly Thr Cys Val Asn Val Gly Cys 
     50                  55                  60
Ile Pro Lys Lys Leu Met His Gln Ala Ala Leu Leu Gly Gln Ala Leu 
 65                  70                  75                  80
Lys Asp Ser Arg Asn Tyr Gly Trp Lys Leu Glu Asp Thr Val Lys His 
                 85                  90                  95
Asp Trp Glu Lys Met Thr Glu Ser Val Gln Asn His Ile Gly Ser Leu 
             100                105                110
Asn Trp Gly Tyr Arg Val Ala Leu Arg Glu Lys Lys Val Val Tyr Glu 
         115                120                125
Asn Ala Tyr Gly Lys Phe Ile Gly Pro His Lys Ile Met Ala Thr Asn 
     130                135                140
Asn Lys Gly Lys Glu Lys Val Tyr Ser Ala Glu Arg Phe Leu Ile Ala 
 145                150                155                160
Thr Gly Glu Arg Pro Arg Tyr Leu Gly Ile Pro Gly Asp Lys Glu Tyr 
                 165                170                175
Cys Ile Ser Ser Asp Asp Leu Phe Ser Leu Pro Tyr Cys Pro Gly Lys 
             180                185                190
Thr Leu Val Val Gly Ala Ser Tyr Val Ala Leu Glu Cys Ala Gly Phe 
         195                200                205
Leu Ala Gly Ile Gly Leu Asp Val Thr Val Met Val Arg Ser Ile Leu 
     210                215                220
Leu Arg Gly Phe Asp Gln Asp Met Ala Asn Lys Ile Gly Glu His Met 
 225                230                235                240
Glu Glu His Gly Ile Lys Phe Ile Arg Gln Phe Val Pro Thr Lys Ile 
                 245                250                255
Glu Gln Ile Glu Ala Gly Thr Pro Gly Arg Leu Lys Val Thr Ala Lys 
             260                265                270
Ser Thr Asn Ser Glu Glu Thr Ile Glu Asp Glu Phe Asn Thr Val Leu 
         275                280                285
Leu Ala Val Gly Arg Asp Ser Cys Thr Arg Thr Ile Gly Leu Glu Thr 
     290                295                300
Val Gly Val Lys Ile Asn Glu Lys Thr Gly Lys Ile Pro Val Thr Asp 
 305                310                315                320
Glu Glu Gln Thr Asn Val Pro Tyr Ile Tyr Ala Ile Gly Asp Ile Leu 
                 325                330                335
Glu Gly Lys Leu Glu Leu Thr Pro Val Ala Ile Gln Ala Gly Arg Leu 
             340                345                350
Leu Ala Gln Arg Leu Tyr Gly Gly Ser Thr Val Lys Cys Asp Tyr Asp 
         355                360                365
Asn Val Pro Thr Thr Val Phe Thr Pro Leu Glu Tyr Gly Cys Cys Gly 
     370                375                380
Leu Ser Glu Glu Lys Ala Val Glu Lys Phe Gly Glu Glu Asn Ile Glu 
 385                390                395                400
Val Tyr His Ser Phe Phe Trp Pro Leu Glu Trp Thr Val Pro Ser Arg 
                 405                410                415
Asp Asn Asn Lys Cys Tyr Ala Lys Val Ile Cys Asn Leu Lys Asp Asn 
             420                425                430
Glu Arg Val Val Gly Phe His Val Leu Gly Pro Asn Ala Gly Glu Val 
         435                440                445
Thr Gln Ala Leu Gln Pro Leu Lys Cys Gly Leu Thr Lys Gln Gln Leu 
     450                455                460
Asp Ser Thr Ile Gly Ile His Pro Val Cys Ala Glu Ile Phe Thr Thr 
 465                470                475                480
Leu Ser Val Thr Lys Arg Ser Gly Gly Asp Ile Leu Gln Ser Gly Cys 
                 485                490                495



<210> 5400
<211> 3390
<212> DNA
<213> Homo sapiens
<308> AJ001050
<400> 5400

ggcttatca  gagggcaga  ttcaaaagc  actaaaaat  aacggccct  aagatcttc  60
caagtccta  gactatgac  ttatcatca  tggaggtgg  tcaggaggt  tggcagctg  120
taaggaggc  gcccaatat  gcaagaagg  gatggtcct  gactttgtc  ctcccaccc  180
tcttggaac  agatggggt  ttggaggaa  atgtgtgaa  gtgggttgc  tacctaaaa  240
actgatgca  caagcagct  tgttaggac  agccctgca  gactctcga  attatggat  300
gaaagtcga  gagacagtt  agcatgatt  ggacagaat  atagaagct  tacagaatc  360
cattggctc  ttgaattgg  gctaccgag  agctctgcg  gagaaaaaa  tcgtctatg  420
gaatgctta  gggcaattt  ttggtcctc  caggattaa  gcaacaaat  ataaaggca  480
agaaaaaat  tattcagca  agagatttc  cattgccac  ggtgaaaga  cacgttact  540
gggcatccc  ggtgacaag  aatactgca  cagcagtga  gatcttttc  ccttgcctt  600
ctgcccggg  aagaccctg  ttgttggag  atcctatgt  gctttggag  gcgctggat  660
tcttgctgg  attggttta  acgtcactg  tatggttag  tccattctt  ttagaggat  720
tgaccagga  atggccaac  aaattggtg  acacatgga  gaacatggc  tcaagttta  780
aagacagtt  gtaccaatt  aagttgaac  aattgaagc  gggacacca  gccgactca  840
agtagtagc  cagtccacc  atagtgagg  aatcattga  ggagaatat  atacggtga  900
gctggcaat  ggaagagat  cttgcacaa  aaaaattgg  ttagaaacc  taggggtga  960
gataaatga  aagactgga  aaatacctg  cacagatga  gaacagacc  atgtgcctt  1020
catctatgc  attggcgat  tattggagg  taaggtgga  ctcacccca  ttgcaatcc  1080
ggcaggaag  ttgctggct  agaggctct  tgcaggttc  actgtcaag  gtgactatg  1140
aaatgttcc  accactgta  ttactcctt  ggaatatgg  gcttgtggc  tttctgagg  1200
gaaagctgt  gagaagttt  gggaagaaa  tattgaggt  taccatagt  acttttggc  1260
attggaatg  acgattccg  caagagata  caacaaatg  tatgcaaaa  taatctgta  1320
tactaaaga  aatgaacgt  ttgtgggct  tcacgtact  ggtccaaat  ctggagaag  1380
tacacaagg  tttgcagct  cgctcaaat  tggactgac  aaaaagcag  tggacagca  1440
aattggaat  caccctgtc  gtgcagagg  attcacaac  ttgtctgtg  ccaagcgct  1500
tggggcaag  atcctccag  ctggctgct  aggttaagc  ccagtgtgg  tgctgttgc  1560
aagactgca  accactggc  cgtttccgt  cccaaatcc  aggcgaagt  ttctagagg  1620
ttcttgggc  cttggcacc  gcgtgtcct  tgcttacca  cgcccaagg  ccccttgga  1680
ctcttggat  ggagttggt  aatagaagg  aggcagcat  acactgggg  cactgacag  1740
cttgaagct  acatttggc  gggcatcga  gggatgcat  catgaagtc  ccagtctca  1800
gcccatgtg  taggcggtg  tggaacaac  gtcaaatca  ttttagcat  acctttcct  1860
gtggatttt  ttattctcg  tgtcaagtt  tctagggtt  aattttttt  ttttttctc  1920
atggtgtta  tgatattag  gatgaaaaa  gttagcagt  gatttttgt  caaaagcaa  1980
tcatggcta  agtatccat  caaggtgtc  tgttgcatg  aagggatag  ttggctccc  2040
tggaggcta  gtaggcttg  cccgggaaa  agaactgtc  tgcagctga  atggactgt  2100
ctttactga  ctgctcagc  gtttcttct  tcatatatt  ccaaaacaa  tacatctgc  2160
atcaactct  gccaaattt  cccctgtgt  ctacatgat  gatgattat  attttaagg  2220
ctgtttagg  agggaaatg  ctacttggc  agccattgc  tggcatttg  tagtatagt  2280
tgattctca  cattatttg  catggaggc  gacatacac  agaaatggg  gagaaacag  2340
acatatctt  ctgtcttta  tttattgtg  gctggtcta  gcaagctga  atcatttgc  2400
atggaaaac  cgtaacttg  ttaaaagtt  ttctggtag  tttagcttt  tgctaaaaa  2460
aataatgac  ttgggtatc  atttctttc  aagactaca  tagtaggaa  ataagtctt  2520
tcatgctta  gatttagct  ttttgtggt  attgctttt  aaaggaagt  attaatatc  2580
taagttatt  ttaatattt  gaacacagg  ggatgtgaa  gattttcat  taaaaacca  2640
gtggttttg  ctttttctg  tgaatgaac  actgtgcct  gtggaattt  tgcagaagt  2700
tttaggctt  gttagcatt  caacttgca  tattataaa  aggtattaa  gcctcagtt  2760
tgtgtttgt  aatgtactg  ctgaggatt  tctctcagc  gtcttttct  actgtgtag  2820
ttgagtttt  aacacgtgc  tgtggacat  agcctcctg  cagcagttc  tgaagcttc  2880
ttttcattc  tgctactct  cctgtattt  tcagttgca  cactgagtg  tcaaaatac  2940
tttctgggc  acctcaggg  acccatgca  ctgcctggc  tttaggcag  agagcccct  3000
accgtcccc  acaggctct  cctcacgtc  tcatctcat  tggctgtgt  aagaaatgg  3060
aaaagggag  aggagagag  aattgaggc  gttgaccat  ttcagtttt  tttatttat  3120
tttaatttg  ttttttctc  aagtccacc  gtctctgaa  ttagaacag  aggcacggt  3180
tgagataat  aggcctaat  atgttgtga  tctcttttc  tagtggagt  gaatgttct  3240
tccccacaa  aaggattat  tcttataga  ttgtcttgt  cagattctg  atttaccca  3300
tttattgaa  catatacta  gttccatgt  tttttgtta  aaatcttct  aaaaaaaac  3360
aaacaatgt  aaacattaa  attaaaaggc  3390



<210> 5401
<211> 497
<212> PRT
<213> Homo sapiens
<308> Q16881
<400> 5401

Met Asn Gly Pro Glu Asp Leu Pro Lys Ser Tyr Asp Tyr Asp Leu Ile 
  1               5                  10                  15
Ile Ile Gly Gly Gly Ser Gly Gly Leu Ala Ala Ala Lys Glu Ala Ala 
             20                  25                  30
Gln Tyr Gly Lys Lys Val Met Val Leu Asp Phe Val Thr Pro Thr Pro 
         35                  40                  45
Leu Gly Thr Arg Trp Gly Leu Gly Gly Thr Cys Val Asn Val Gly Cys 
     50                  55                  60
Ile Pro Lys Lys Leu Met His Gln Ala Ala Leu Leu Gly Gln Ala Leu 
 65                  70                  75                  80
Gln Asp Ser Arg Asn Tyr Gly Trp Lys Val Glu Glu Thr Val Lys His 
                 85                  90                  95
Asp Trp Asp Arg Met Ile Glu Ala Val Gln Asn His Ile Gly Ser Leu 
             100                105                110
Asn Trp Gly Tyr Arg Val Ala Leu Arg Glu Lys Lys Val Val Tyr Glu 
         115                120                125
Asn Ala Tyr Gly Gln Phe Ile Gly Pro His Arg Ile Lys Ala Thr Asn 
     130                135                140
Asn Lys Gly Lys Glu Lys Ile Tyr Ser Ala Glu Ser Phe Leu Ile Ala 
 145                150                155                160
Thr Gly Glu Arg Pro Arg Tyr Leu Gly Ile Pro Gly Asp Lys Glu Tyr 
                 165                170                175
Cys Ile Ser Ser Asp Asp Leu Phe Ser Leu Pro Tyr Cys Pro Gly Lys 
             180                185                190
Thr Leu Val Val Gly Ala Ser Tyr Val Ala Leu Glu Cys Ala Gly Phe 
         195                200                205
Leu Ala Gly Ile Gly Leu Gly Val Thr Val Met Val Arg Ser Ile Leu 
     210                215                220
Leu Arg Gly Phe Asp Gln Asp Met Ala Asn Lys Ile Gly Glu His Met 
 225                230                235                240
Glu Glu His Gly Ile Lys Phe Ile Arg Gln Phe Val Pro Ile Lys Val 
                 245                250                255
Glu Gln Ile Glu Ala Gly Thr Pro Gly Arg Leu Arg Val Val Ala Gln 
             260                265                270
Ser Thr Asn Ser Glu Glu Ile Ile Glu Gly Glu Tyr Asn Thr Val Met 
         275                280                285
Leu Ala Ile Gly Arg Asp Ala Cys Thr Arg Lys Ile Gly Leu Glu Thr 
     290                295                300
Val Gly Val Lys Ile Asn Glu Lys Thr Gly Lys Ile Pro Val Thr Asp 
 305                310                315                320
Glu Glu Gln Thr Asn Val Pro Tyr Ile Tyr Ala Ile Gly Asp Ile Leu 
                 325                330                335
Glu Asp Lys Val Glu Leu Thr Pro Val Ala Ile Gln Ala Gly Arg Leu 
             340                345                350
Leu Ala Gln Arg Leu Tyr Ala Gly Ser Thr Val Lys Cys Asp Tyr Glu 
         355                360                365
Asn Val Pro Thr Thr Val Phe Thr Pro Leu Glu Tyr Gly Ala Cys Gly 
     370                375                380
Leu Ser Glu Glu Lys Ala Val Glu Lys Phe Gly Glu Glu Asn Ile Glu 
 385                390                395                400
Val Tyr His Ser Tyr Phe Trp Pro Leu Glu Trp Thr Ile Pro Ser Arg 
                 405                410                415
Asp Asn Asn Lys Cys Tyr Ala Lys Ile Ile Cys Asn Thr Lys Asp Asn 
             420                425                430
Glu Arg Val Val Gly Phe His Val Leu Gly Pro Asn Ala Gly Glu Val 
         435                440                445
Thr Gln Gly Phe Ala Ala Ala Leu Lys Cys Gly Leu Thr Lys Lys Gln 
     450                455                460
Leu Asp Ser Thr Ile Gly Ile His Pro Val Cys Ala Glu Val Phe Thr 
 465                470                475                480
Thr Leu Ser Val Thr Lys Arg Ser Gly Ala Ser Ile Leu Gln Ala Gly 
                 485                490                495
Cys 
             500



<210> 5402
<211> 465
<212> DNA
<213> Rattus norvegicus
<308> AA891308
<400> 5402

agaaatttt  gtacagtgt  cattgaaaa  atgtaaaat  ttgaagtgt  taacaaatg  60
cattacagt  tctttaata  aggttcatt  ataaatact  agtgtgtgc  gcggtcatt  120
ttcttgtaa  tgcagttcc  taattaata  tgtttcccc  agcggagaa  acttagaca  180
agcacagac  acacactgc  gccccagga  gacagtggc  ctacattcc  cagatagct  240
acttttttt  gccacatgg  gctggttag  caagcctta  gctccccaa  tatgctgac  300
ctcccacgt  ctgctggca  atacctcga  gacaaagga  cagctctgg  tggtctcca  360
ggaggacac  gtggtcacg  acacactgc  tccctcagc  atgctccta  ctaaagtca  420
ttgggccca  ccactcata  gcactgcag  tgcctgctg  ctgtc  465



<210> 5403
<211> 1091
<212> PRT
<213> Rattus norvegicus
<308> NP_032403
<400> 5403

Met Ala Arg Pro Gly Pro Gly Val Leu Gly Ala Pro Arg Leu Ala Pro 
  1               5                  10                  15
Arg Leu Leu Leu Trp Leu Leu Leu Leu Leu Leu Gln Trp Pro Glu Ser 
             20                  25                  30
Ala Gly Ala Gln Ala Arg Pro Arg Ala Pro Cys Ala Ala Ala Cys Thr 
         35                  40                  45
Cys Ala Gly Asn Ser Leu Asp Cys Ser Gly Arg Gly Leu Ala Thr Leu 
     50                  55                  60
Pro Arg Asp Leu Pro Ser Trp Thr Arg Ser Leu Asn Leu Ser Tyr Asn 
 65                  70                  75                  80
Arg Leu Ser Glu Ile Asp Ser Ala Ala Phe Glu Asp Leu Thr Asn Leu 
                 85                  90                  95
Gln Glu Val Tyr Leu Asn Ser Asn Glu Leu Thr Ala Ile Pro Ser Leu 
             100                105                110
Gly Thr Ala Ser Ile Gly Val Val Ser Leu Phe Leu Gln His Asn Lys 
         115                120                125
Ile Leu Ser Val Asp Gly Ser Gln Leu Lys Ser Tyr Leu Ser Leu Glu 
     130                135                140
Val Leu Asp Leu Ser Ser Asn Asn Ile Thr Glu Ile Arg Ser Ser Cys 
 145                150                155                160
Phe Pro Asn Gly Leu Arg Ile Arg Glu Leu Asn Leu Ala Ser Asn Arg 
                 165                170                175
Ile Ser Ile Leu Glu Ser Gly Ala Phe Asp Gly Leu Ser Arg Ser Leu 
             180                185                190
Leu Thr Leu Arg Leu Ser Lys Asn Arg Ile Thr Gln Leu Pro Val Lys 
         195                200                205
Ala Phe Lys Leu Pro Arg Leu Thr Gln Leu Asp Leu Asn Arg Asn Arg 
     210                215                220
Ile Arg Leu Ile Glu Gly Leu Thr Phe Gln Gly Leu Asp Ser Leu Glu 
 225                230                235                240
Val Leu Arg Leu Gln Arg Asn Asn Ile Ser Arg Leu Thr Asp Gly Ala 
                 245                250                255
Phe Trp Gly Leu Ser Lys Met His Val Leu His Leu Glu Tyr Asn Ser 
             260                265                270
Leu Val Glu Val Asn Ser Gly Ser Leu Tyr Gly Leu Thr Ala Leu His 
         275                280                285
Gln Leu His Leu Ser Asn Asn Ser Ile Ser Arg Ile Gln Arg Asp Gly 
     290                295                300
Trp Ser Phe Cys Gln Lys Leu His Glu Leu Ile Leu Ser Phe Asn Asn 
 305                310                315                320
Leu Thr Arg Leu Asp Glu Glu Ser Leu Ala Glu Leu Ser Ser Leu Ser 
                 325                330                335
Ile Leu Arg Leu Ser His Asn Ala Ile Ser His Ile Ala Glu Gly Ala 
             340                345                350
Phe Lys Gly Leu Lys Ser Leu Arg Val Leu Asp Leu Asp His Asn Glu 
         355                360                365
Ile Ser Gly Thr Ile Glu Asp Thr Ser Gly Ala Phe Thr Gly Leu Asp 
     370                375                380
Asn Leu Ser Lys Leu Thr Leu Phe Gly Asn Lys Ile Lys Ser Val Ala 
 385                390                395                400
Lys Arg Ala Phe Ser Gly Leu Glu Ser Leu Glu His Leu Asn Leu Gly 
                 405                410                415
Glu Asn Ala Ile Arg Ser Val Gln Phe Asp Ala Phe Ala Lys Met Lys 
             420                425                430
Asn Leu Lys Glu Leu Tyr Ile Ser Ser Glu Ser Phe Leu Cys Asp Cys 
         435                440                445
Gln Leu Lys Trp Leu Pro Pro Trp Leu Met Gly Arg Met Leu Gln Ala 
     450                455                460
Phe Val Thr Ala Thr Cys Ala His Pro Glu Ser Leu Lys Gly Gln Ser 
 465                470                475                480
Ile Phe Ser Val Leu Pro Asp Ser Phe Val Cys Asp Asp Phe Pro Lys 
                 485                490                495
Pro Gln Ile Ile Thr Gln Pro Glu Thr Thr Met Ala Val Val Gly Lys 
             500                505                510
Asp Ile Arg Phe Thr Cys Ser Ala Ala Ser Ser Ser Ser Ser Pro Met 
         515                520                525
Thr Phe Ala Trp Lys Lys Asp Asn Glu Val Leu Ala Asn Ala Asp Met 
     530                535                540
Glu Asn Phe Ala His Val Arg Ala Gln Asp Gly Glu Val Met Glu Tyr 
 545                550                555                560
Thr Thr Ile Leu His Leu Arg His Val Thr Phe Gly His Glu Gly Arg 
                 565                570                575
Tyr Gln Cys Ile Ile Thr Asn His Phe Gly Ser Thr Tyr Ser His Lys 
             580                585                590
Ala Arg Leu Thr Val Asn Val Leu Pro Ser Phe Thr Lys Ile Pro His 
         595                600                605
Asp Ile Ala Ile Arg Thr Gly Thr Thr Ala Arg Leu Glu Cys Ala Ala 
     610                615                620
Thr Gly His Pro Asn Pro Gln Ile Ala Trp Gln Lys Asp Gly Gly Thr 
 625                630                635                640
Asp Phe Pro Ala Ala Arg Glu Arg Arg Met His Val Met Pro Asp Asp 
                 645                650                655
Asp Val Phe Phe Ile Thr Asp Val Lys Ile Asp Asp Met Gly Val Tyr 
             660                665                670
Ser Cys Thr Ala Gln Asn Ser Ala Gly Ser Val Ser Ala Asn Ala Thr 
         675                680                685
Leu Thr Val Leu Glu Thr Pro Ser Leu Ala Val Pro Leu Glu Asp Arg 
     690                695                700
Val Val Thr Val Gly Glu Thr Val Ala Phe Gln Cys Lys Ala Thr Gly 
 705                710                715                720
Ser Pro Thr Pro Arg Ile Thr Trp Leu Lys Gly Gly Arg Pro Leu Ser 
                 725                730                735
Leu Thr Glu Arg His His Phe Thr Pro Gly Asn Gln Leu Leu Val Val 
             740                745                750
Gln Asn Val Met Ile Asp Asp Ala Gly Arg Tyr Thr Cys Glu Met Ser 
         755                760                765
Asn Pro Leu Gly Thr Glu Arg Ala His Ser Gln Leu Ser Ile Leu Pro 
     770                775                780
Thr Pro Gly Cys Arg Lys Asp Gly Thr Thr Val Gly Ile Phe Thr Ile 
 785                790                795                800
Ala Val Val Cys Ser Ile Val Leu Thr Ser Leu Val Trp Val Cys Ile 
                 805                810                815
Ile Tyr Gln Thr Arg Lys Lys Ser Glu Glu Tyr Ser Val Thr Asn Thr 
             820                825                830
Asp Glu Thr Ile Val Pro Pro Asp Val Pro Ser Tyr Leu Ser Ser Gln 
         835                840                845
Gly Thr Leu Ser Asp Arg Gln Glu Thr Val Val Arg Thr Glu Gly Gly 
     850                855                860
His Gln Ala Asn Gly His Ile Glu Ser Asn Gly Val Cys Leu Arg Asp 
 865                870                875                880
Pro Ser Leu Phe Pro Glu Val Asp Ile His Ser Thr Thr Cys Arg Gln 
                 885                890                895
Pro Lys Leu Cys Val Gly Tyr Thr Arg Glu Pro Trp Lys Val Thr Glu 
             900                905                910
Lys Ala Asp Arg Thr Ala Ala Pro His Thr Thr Ala His Ser Gly Ser 
         915                920                925
Ala Val Cys Ser Asp Cys Ser Thr Asp Thr Ala Tyr His Pro Gln Pro 
     930                935                940
Val Pro Arg Asp Ser Gly Gln Pro Gly Thr Ala Ser Ser Gln Glu Leu 
 945                950                955                960
Arg Gln His Asp Arg Glu Tyr Ser Pro His His Pro Tyr Ser Gly Thr 
                 965                970                975
Ala Asp Gly Ser His Thr Leu Ser Gly Gly Ser Leu Tyr Pro Ser Asn 
             980                985                990
His Asp Arg Ile Leu Pro Ser Leu Lys Asn Lys Ala Ala Ser Ala Asp 
         995                1000                1005
Gly Asn Gly Asp Ser Ser Trp Thr Leu Ala Lys Leu His Glu Ala Asp 
     1010                1015                1020
Cys Ile Asp Leu Lys Pro Ser Pro Thr Leu Ala Ser Gly Ser Pro Glu 
 1025                1030                1035                1040
Leu Met Glu Asp Ala Ile Ser Thr Glu Ala Gln His Leu Leu Val Ser 
                 1045                1050                1055
Asn Gly His Leu Pro Lys Ala Cys Asp Ser Ser Pro Glu Ser Val Pro 
             1060                1065                1070
Leu Lys Gly Gln Ile Thr Gly Lys Arg Arg Gly Pro Leu Leu Leu Ala 
         1075                1080                1085
Pro Arg Ser 
     1090



<210> 5404
<211> 2958
<212> DNA
<213> Homo sapiens
<308> AL117666
<400> 5404

acgcgtccg  accgtggcc  gcctcgaat  tgctgccac  ggtcaccca  accctcaga  60
tgcctggca  aaggatgga  gcacggatt  ccccgctgc  cgtgagcga  gcatgcatg  120
catgccgga  gacgacgtg  ttttcatca  tgatgtgaa  atagatgac  caggggttt  180
cagctgtac  gctcagaac  cagccggtt  tatttcagc  aatgccacc  tgactgtcc  240
agagacccc  tccttggtg  tccccttgg  agaccgtgt  gtatctgtg  gagaaacag  300
ggccctcca  tgcaaagcc  cggggaacc  tccgccccg  atcacctgg  tcaaggggg  360
ccgcccgct  agcctcact  agcggcacc  cctgacccc  gacaaccag  tcctggtgg  420
tcagaacgt  gtggcagag  atgcgggcc  atatacctg  gagatgtcc  acaccctgg  480
cacggagcg  gctcacagc  agctgagcg  cctgcccgc  gcaggctgc  ggaaggatg  540
gaccacggt  ggcatcttc  ccattgctg  cgtgagcag  atcgtcctg  cgtcactgg  600
ctgggtgtg  atcatctac  agaccagga  gaagagtga  gagtacagt  tcaccaaca  660
agatgaaac  gtcgtgcca  cagatgttc  aagctacct  tcttctcag  ggacccttt  720
tgaccgaca  gaaaccgtg  tcaggaccg  gggtggccc  caggccaat  ggcacattg  780
gagcaatgg  gtgtgtcca  gagatgcaa  ccactttcc  gagcccgac  ctcacagcg  840
tgcctgcag  cagccaaag  tctgtgctg  gtctgcgta  cacaaagag  cgtggaaag  900
gatggagaa  gctgaaggg  cacctgggc  acataagat  gaacacggt  gccgggtcg  960
atgcagtga  tgcaacacc  aagtggact  ttactccag  ggacaagcc  tccaccccc  1020
gcctgtgtc  agagacagc  cacagccaa  tgcgccaaa  ggcccggag  cgggtggga  1080
tgaccaaga  cattctcca  atcaccagt  cagcaggac  gccgctggg  cctgccccg  1140
gtgccaagg  tcgctctac  ccagtaacc  cgatagaat  ctgacggct  tgaagaaaa  1200
gccaatggc  tctctagat  ggaaagggg  ttcttcctg  actttagca  ggttgtatc  1260
cccggactc  acagagcta  agcctgcat  ttcattaac  tcaggcagt  cagagcgcg  1320
ggaagccca  tacttgctt  tttccaatg  ccacctccc  aaagcatgt  acgccagtc  1380
cgagtccac  ccactgaca  gacagctcc  cgggaaaca  agggtgcca  tgctgttgg  1440
accaaaaag  taggttttg  ctacctcag  tcttgtcat  ccaatctct  cgggaaaga  1500
aggtaggag  ggctgcgag  aagcttggg  tcaagcgtc  ctcatctgt  catagttgt  1560
actcccatg  ggagtatca  tcgctcaca  gacttggat  tgaagcaca  taaacgcaa  1620
aggggattt  tgtacaaaa  gcaaaaaaa  gtatttgat  tcattgtac  taagagttt  1680
cagagattt  atatatatc  tttacagag  ctattttaa  ctttagtgc  tggttaaca  1740
aaaaaaatt  tacaatttt  acaatatta  ttttcgtat  aggttgctg  ttaattttg  1800
agggggtgg  gaaatagtt  tggtgcctt  acgcatggc  ggaatttat  gaggctaca  1860
ccacatttg  tcacaggag  ttttggtgc  gggtgggaa  gatggaagg  cttggattt  1920
tattgcact  catagaccc  taggctgct  tgcggtggg  ctccacatg  gccggaagg  1980
gcttcaggt  agcactgct  atgtgtgga  gcccctgca  caggcttcc  tgtctgtag  2040
gccaggggt  caagtgcca  ccacacttg  agtgaatgg  ttttccttt  aggtttaag  2100
cctgtctgt  tgtaaggcg  agaatctgt  cgtctgtaa  gcgtagaat  agggttgtt  2160
atccatcac  agcaaaagg  cagaacagt  aaacactgc  tttcctcct  ctcttattt  2220
atgataaaa  caaatgtgg  cttctcagt  tcattcgat  gctatttga  acttttaaa  2280
taaggtaaa  gctgctggt  ttggtacct  tggattttt  tatactgat  ttttcgttt  2340
gccaatata  tgagtatta  attggcctt  ggggacaga  aggaggaag  tctgacttt  2400
cagggctac  ttatttcta  taaggaccc  gagcaggcc  gtccatgcc  ttccttcgc  2460
cagatgaaa  tgagctggg  ctggaaagg  cagcccttg  cctgggttc  gggtataat  2520
tgcactttt  agactggta  ctaaccatc  tatgagtgc  aatgtgtca  ttagtaaaa  2580
ttaaataga  acaaggtcc  tcaaatgtt  ctttggcca  aagctgaag  gagttactg  2640
gaaaatagt  aacaattac  gtcaggtgt  atcactgtt  aaaaggtaa  cacatttag  2700
attttgttc  tgacagtta  ctgactaat  ttacttcca  aaaatatgt  aatttgctg  2760
ttctgagag  caatgtgaa  gagggagta  tacttttat  tacaaagtt  tttatttat  2820
gaaattttg  tacagtgta  attgaaaac  atgtaaaat  ttgaagtgt  taacaaatg  2880
cattgaagt  tctttaata  aggttcatt  ataaatgtc  aaaaaaaat  ttttaaaaa  2940
taaaaaaaa  aaaaaaaa  2958



<210> 5405
<211> 420
<212> PRT
<213> Homo sapiens
<308> BC014276
<400> 5405

Ala Arg Gly Ser Ala Gly Ser Ile Ser Ala Asn Ala Thr Leu Thr Val 
  1               5                  10                  15
Leu Glu Thr Pro Ser Leu Val Val Pro Leu Glu Asp Arg Val Val Ser 
             20                  25                  30
Val Gly Glu Thr Val Ala Leu Gln Cys Lys Ala Thr Gly Asn Pro Pro 
         35                  40                  45
Pro Arg Ile Thr Trp Phe Lys Gly Asp Arg Pro Leu Ser Leu Thr Glu 
     50                  55                  60
Arg His His Leu Thr Pro Asp Asn Gln Leu Leu Val Val Gln Asn Val 
 65                  70                  75                  80
Val Ala Glu Asp Ala Gly Arg Tyr Thr Cys Glu Met Ser Asn Thr Leu 
                 85                  90                  95
Gly Thr Glu Arg Ala His Ser Gln Leu Ser Val Leu Pro Ala Ala Gly 
             100                105                110
Cys Arg Lys Asp Gly Thr Thr Val Gly Ile Phe Thr Ile Ala Val Val 
         115                120                125
Ser Ser Ile Val Leu Thr Ser Leu Val Trp Val Cys Ile Ile Tyr Gln 
     130                135                140
Thr Arg Lys Lys Ser Glu Glu Tyr Ser Val Thr Asn Thr Asp Glu Thr 
 145                150                155                160
Val Val Pro Pro Asp Val Pro Ser Tyr Leu Ser Ser Gln Gly Thr Leu 
                 165                170                175
Ser Asp Arg Gln Glu Thr Val Val Arg Thr Glu Gly Gly Pro Gln Ala 
             180                185                190
Asn Gly His Ile Glu Ser Asn Gly Val Cys Pro Arg Asp Ala Ser His 
         195                200                205
Phe Pro Glu Pro Asp Thr His Ser Val Ala Cys Arg Gln Pro Lys Leu 
     210                215                220
Cys Ala Gly Ser Ala Tyr His Lys Glu Pro Trp Lys Ala Met Glu Lys 
 225                230                235                240
Ala Glu Gly Thr Pro Gly Pro His Lys Met Glu His Gly Gly Arg Val 
                 245                250                255
Val Cys Ser Asp Cys Asn Thr Glu Val Asp Cys Tyr Ser Arg Gly Gln 
             260                265                270
Ala Phe His Pro Gln Pro Val Ser Arg Asp Ser Ala Gln Pro Ser Ala 
         275                280                285
Pro Asn Gly Pro Glu Pro Gly Gly Ser Asp Gln Glu His Ser Pro His 
     290                295                300
His Gln Cys Ser Arg Thr Ala Ala Gly Ser Cys Pro Glu Cys Gln Gly 
 305                310                315                320
Ser Leu Tyr Pro Ser Asn His Asp Arg Met Leu Thr Ala Val Lys Lys 
                 325                330                335
Lys Pro Met Ala Ser Leu Asp Gly Lys Gly Asp Ser Ser Trp Thr Leu 
             340                345                350
Ala Arg Leu Tyr His Pro Asp Ser Thr Glu Leu Gln Pro Ala Ser Ser 
         355                360                365
Leu Thr Ser Gly Ser Pro Glu Arg Ala Glu Ala Gln Tyr Leu Leu Val 
     370                375                380
Ser Asn Gly His Leu Pro Lys Ala Cys Asp Ala Ser Pro Glu Ser Thr 
 385                390                395                400
Pro Leu Thr Gly Gln Leu Pro Gly Lys Gln Arg Val Pro Leu Leu Leu 
                 405                410                415
Ala Pro Lys Ser 
             420



<210> 5406
<211> 485
<212> DNA
<213> Rattus norvegicus
<308> AA891314
<400> 5406

ctggtcgct  agaatattt  ttcaaaaac  gggattgaa  aaaactgta  agagtgtct  60
ctgctgaga  ctgggcccc  gccccccag  ccacacccc  tgctatagg  agagccctc  120
ctttgggtt  ccccccgga  aagcccatc  agtctattc  agtcaaaag  gtatcagtg  180
aagcagcag  atctgcagg  gatgaagag  agcttggcc  cagccaccc  tcactctcc  240
ccaattccc  ctggggcag  aggaagaag  ccaaaggga  ggagaggac  cgagtagcc  300
ctcccacgg  agggcactg  ggaggcccc  gctactccc  gcatccaag  ataggtctg  360
aggggtgga  cccctgctc  ggggctgcc  aactcctag  accctgggc  aggaactgt  420
ccctctctg  ggaggatct  caaagatgg  gcaaggtan  gggtgcatc  atgcgtctg  480
catta  485



<210> 5407
<211> 1964
<212> DNA
<213> Homo sapiens
<308> AF176330
<400> 5407

cctctggag  ccctgtggc  gaactcaaa  ggaaggagg  gcagctgca  ccaggggag  60
agggtgtca  ctccgttgg  tagagccgg  caggttgca  cgcggacac  ctcgcaggt  120
gctgtggcc  cagcctcgc  tgacagaat  agcggctcg  acgggggac  ggaggagga  180
ccagagctc  gcatcaccc  cacgctgcg  atgctgatg  acgggaagg  agtgggcag  240
atcatcggg  agaagggcg  gactgtaaa  cgaatccgg  agcagagca  tgcccggat  300
accatctcc  agggctcct  ccctgaacg  atcaccacc  tcaccgggt  tacagcagc  360
gtcttccat  cagtctcca  gattgcttt  aaactggat  aggaccttt  tgctgctcc  420
gcaaatggt  gaaatgtct  caggcctcc  gtgaccctg  gccttgtca  ccctgccag  480
cagtgtggc  cactgattg  gaaggctgg  accaagatc  aggagatcc  agagactac  540
ggtgcccag  tacaggtgg  aggggacct  ctccccaac  ccacagagc  agctgttac  600
gtatctggg  tgcctgatg  catcatcct  tgtgtgcgc  agatctgcg  tgttatcct  660
gagtcccca  ccaaaggag  cactatccc  taccatccg  gcctctccc  aggtactgt  720
cttctctct  ccaaccagg  cttctctgt  cagggtcag  atggggctg  gaccccagc  780
gaggtcacc  agctccagc  gctctcaag  catgcggtc  cctttgcca  acccagcgt  840
gtgccagga  tggatcccg  cacacagac  agctcacag  agttcttgg  tcccaacga  900
ttgattggc  gtgtgatcg  gcgccaggg  agcaagatc  gcgagatcc  gcagatgtc  960
ggggcacat  tcaagatcg  gaaccaagc  gagggcgct  gggagcggc  tgtcaccat  1020
actggctct  cggtctcca  cgccctggc  cagtacctc  tcactgcct  tctagagac  1080
gccaagtct  cctctgggg  gacgcccag  tcggccccc  cagacctgc  tgccccctt  1140
tcgccaccc  tgacggccc  gcccacagc  ccccctggc  tgctgggca  accctatgc  1200
atctccctc  ccaacttca  cggcctcaa  cccatgccc  tcttggctt  accacctgc  1260
tccccaggg  cgccgccgg  cttggcggc  tacactgcc  agatggcag  agctaatgg  1320
agcaagaag  ctgagcggc  gaaattctc  ccctactga  gccagctga  gtacaggca  1380
gggcaggca  gaccaccag  agggggctg  ctctgcacc  tacccgccc  aggagactc  1440
accctgggg  cccaaacgc  gctaacgcc  agacgcatg  atgcacccc  taccctgcc  1500
ccatctatg  gagttcttt  tctcagagt  ggggcagtt  ctggcccag  ggtctgagc  1560
gcggcagcc  cagggcagg  ggccctacc  cctcagctc  gtgcttgga  acagggagc  1620
gccaggaga  tccctagtg  ccccaccat  gcgggtgtc  ctcacgcac  ccccatccc  1680
tagggcttc  tggcctact  catccttgt  ggagtcagg  aggagggcc  gttgggtag  1740
tggggccag  cttctctcc  caccacctg  agatttctt  ctgcttcca  tgataccct  1800
ttgactgga  tgaactggc  gggcttgtc  gggggcacc  caaagaggg  gcactgcca  1860
gtagctggg  gagtggcat  gggcagggg  ccagttctc  gcagcagac  ctctgtaca  1920
ttttttcaa  ccctgtttt  gaataaata  tctcagcga  cagg  1964



<210> 5408
<211> 403
<212> PRT
<213> Homo sapiens
<308> P57723
<400> 5408

Met Ser Gly Ser Asp Gly Gly Leu Glu Glu Glu Pro Glu Leu Ser Ile 
  1               5                  10                  15
Thr Leu Thr Leu Arg Met Leu Met His Gly Lys Glu Val Gly Ser Ile 
             20                  25                  30
Ile Gly Lys Lys Gly Glu Thr Val Lys Arg Ile Arg Glu Gln Ser Ser 
         35                  40                  45
Ala Arg Ile Thr Ile Ser Glu Gly Ser Cys Pro Glu Arg Ile Thr Thr 
     50                  55                  60
Ile Thr Gly Ser Thr Ala Ala Val Phe His Ala Val Ser Met Ile Ala 
 65                  70                  75                  80
Phe Lys Leu Asp Glu Asp Leu Cys Ala Ala Pro Ala Asn Gly Gly Asn 
                 85                  90                  95
Val Ser Arg Pro Pro Val Thr Leu Arg Leu Val Ile Pro Ala Ser Gln 
             100                105                110
Cys Gly Ser Leu Ile Gly Lys Ala Gly Thr Lys Ile Lys Glu Ile Arg 
         115                120                125
Glu Thr Thr Gly Ala Gln Val Gln Val Ala Gly Asp Leu Leu Pro Asn 
     130                135                140
Ser Thr Glu Arg Ala Val Thr Val Ser Gly Val Pro Asp Ala Ile Ile 
 145                150                155                160
Leu Cys Val Arg Gln Ile Cys Ala Val Ile Leu Glu Ser Pro Pro Lys 
                 165                170                175
Gly Ala Thr Ile Pro Tyr His Pro Ser Leu Ser Leu Gly Thr Val Leu 
             180                185                190
Leu Ser Ala Asn Gln Gly Phe Ser Val Gln Gly Gln Tyr Gly Ala Val 
         195                200                205
Thr Pro Ala Glu Val Thr Lys Leu Gln Gln Leu Ser Ser His Ala Val 
     210                215                220
Pro Phe Ala Thr Pro Ser Val Val Pro Gly Leu Asp Pro Gly Thr Gln 
 225                230                235                240
Thr Ser Ser Gln Glu Phe Leu Val Pro Asn Asp Leu Ile Gly Cys Val 
                 245                250                255
Ile Gly Arg Gln Gly Ser Lys Ile Ser Glu Ile Arg Gln Met Ser Gly 
             260                265                270
Ala His Ile Lys Ile Gly Asn Gln Ala Glu Gly Ala Gly Glu Arg His 
         275                280                285
Val Thr Ile Thr Gly Ser Pro Val Ser Ile Ala Leu Ala Gln Tyr Leu 
     290                295                300
Ile Thr Ala Cys Leu Glu Thr Ala Lys Ser Thr Ser Gly Gly Thr Pro 
 305                310                315                320
Ser Ser Ala Pro Ala Asp Leu Pro Ala Pro Phe Ser Pro Pro Leu Thr 
                 325                330                335
Ala Leu Pro Thr Ala Pro Pro Gly Leu Leu Gly Thr Pro Tyr Ala Ile 
             340                345                350
Ser Leu Ser Asn Phe Ile Gly Leu Lys Pro Met Pro Phe Leu Ala Leu 
         355                360                365
Pro Pro Ala Ser Pro Gly Pro Pro Pro Gly Leu Ala Ala Tyr Thr Ala 
     370                375                380
Lys Met Ala Ala Ala Asn Gly Ser Lys Lys Ala Glu Arg Gln Lys Phe 
 385                390                395                400
Ser Pro Tyr 
                 405



<210> 5409
<211> 438
<212> DNA
<213> Rattus norvegicus
<308> AA891322
<400> 5409

aacaggaaa  taattttat  cttaaatcc  agggatcag  acaaaaaac  tctgccctc  60
aagggcaag  caaggtgga  aggctagga  ggcagacag  aaggcagga  catgtccac  120
acagaggcc  cttcattca  gcgctgcct  catcagaaa  aatttctct  gggccatgt  180
cccatcccc  ccctcggcc  ccatgtaca  gtctcgacc  tcactacct  gcccttcca  240
cccattgtc  tgaccgctc  cacccccac  ccgggcctt  cctgccccg  tcactgccc  300
gctccccac  cttgtgctc  ctatcccgg  cacggtctc  gtctcgacg  cgttccctc  360
cacttcggt  acttcgacg  ctctcccgg  ctcgatccc  acccttctc  tcagggnca  420
canggcctt  aaggccaa  438



<210> 5410
<211> 121
<212> PRT
<213> Rattus norvegicus
<308> AAH02169
<400> 5410

Met Ala Glu Pro Ser Glu Ala Gly Asp Gly Ala Pro Asp Asp Gly Pro 
  1               5                  10                  15
Pro Gly Glu Leu Gly Pro Glu Gly Pro Asp Gly Pro Glu Glu Lys Gly 
             20                  25                  30
Arg Asp Arg Asp Arg Glu Arg Arg Arg Ser His Arg Ser Glu Arg Glu 
         35                  40                  45
Arg Arg Arg Asp Arg Asp Arg Asp Arg Asp Arg Glu His Lys Arg Gly 
     50                  55                  60
Glu Arg Gly Ser Glu Arg Gly Arg Asp Glu Ala Arg Gly Gly Gly Gly 
 65                  70                  75                  80
Ser Gly Gln Asp Asn Gly Leu Glu Gly Leu Gly Ser Asp Gly Arg Asp 
                 85                  90                  95
Met Tyr Met Glu Ala Glu Gly Gly Asp Gly Tyr Met Ala Pro Glu Asn 
             100                105                110
Gly Tyr Leu Met Glu Ala Ala Pro Glu 
         115                120



<210> 5411
<211> 1672
<212> DNA
<213> Homo sapiens
<308> X06815
<400> 5411

gcgctcgct  agcgggcga  ggaatcaga  ggacgtgga  gcccccgga  tggaagccg  60
agcaggagt  gttgttgct  aggggctgc  gcagccgcc  cgagcctcc  gacagacgc  120
agagcgagg  ggcgctacg  gacttggca  gatgaccca  ttcctgccg  ccaaccttc  180
ggccctctt  gccccccgt  accctattc  atacctgcc  cccctggag  aactgccac  240
tgaaaaaca  cacaatcaa  cttattgtg  cattgcgcc  tacattcga  agtttgagg  300
ccctcgaga  gcccctcct  caactcgtg  tgaaacccg  gaggagcgc  tggagagga  360
aagacggga  aagattgag  ggcgacagc  agaagtgga  acagagctt  aaatgtggg  420
ccctcacaa  gatcccaat  ctcaggggg  tgccttcaa  actctcttc  tggcgagag  480
gaattatga  acaacagaa  ccaagctcc  gagagagtt  gaggtgtac  gacctatca  540
aagaataca  atggtctac  gtaagcggt  aggaaagcc  cgtggctat  ccttcatcg  600
gtacgaaca  gagcgagac  tgcactcca  cacgcagct  gcttgcagc  gatgcttac  660
ctcccctta  aacacctca  tgtatggtt  gtataaggc  gcttacaaa  acgcagatg  720
caagaagat  gatggcagg  gggtccttg  ggacgtgga  aggggccga  ccgtgaagg  780
ctggaggcc  cggcggcta  gaggaggcc  cggtggtac  agaagagga  gggctgatg  840
gaacatccg  cattcaggc  gcgatgaca  ctcccgcta  gatgagagg  accgggacc  900
ggaccgtga  cgggagcgc  gagagcgga  ccgggagcg  gacaaggag  gagaacggc  960
acgctcccg  tcccgggac  ggcggaggc  ctcacggag  cgcgacaag  aggagcgga  1020
gcgctccag  gagcggagc  aggacaagg  ccgggaccg  aagcggcga  gcagccgga  1080
tcgggagcg  gcccggcgg  agcgggagc  caaggagga  ctgcgtggc  gcggtggcg  1140
catggcgga  ccctccgag  cgggtgacg  gccccctga  gatgggcct  caggggagc  1200
cgggcctga  ggccctgac  gtccagagg  aaagggccg  gatcgtgac  gggagcgac  1260
gcggagcca  cggagcgag  gcgagcggc  ccgggaccg  gatcgtgac  gtgaccgtg  1320
ccgcgagca  aaacggggg  agcggggca  tgagcgggg  agggatgag  cccgaggtg  1380
gggcggtgg  caggacaac  ggctggagg  tctgggcaa  gacagccga  acatgtaca  1440
ggagtctga  ggcggcgac  gctacctgg  tccggagaa  gggtatttg  tggaggctg  1500
gccggagtg  agaggtcgt  ctctccatc  gctgtgttt  gacgcgttc  tgcccagcc  1560
cttgctgtc  tcccctccc  caaccttgg  cacttgagt  tgtcctcca  gggtaggtg  1620
ctcatttgt  ctggcccct  ggatttaaa  ataaaatta  tttcctgtt  at  1672



<210> 5412
<211> 437
<212> PRT
<213> Homo sapiens
<308> Q9UE46
<400> 5412

Met Thr Gln Phe Leu Pro Pro Asn Leu Leu Ala Leu Phe Ala Pro Arg 
  1               5                  10                  15
Asp Pro Ile Pro Tyr Leu Pro Pro Leu Glu Lys Leu Pro His Glu Lys 
             20                  25                  30
His His Asn Gln Pro Tyr Cys Gly Ile Ala Pro Tyr Ile Arg Glu Phe 
         35                  40                  45
Glu Asp Pro Arg Asp Ala Pro Pro Pro Thr Arg Ala Glu Thr Arg Glu 
     50                  55                  60
Glu Arg Met Glu Arg Lys Arg Arg Glu Lys Ile Glu Arg Arg Gln Gln 
 65                  70                  75                  80
Glu Val Glu Thr Glu Leu Lys Met Trp Asp Pro His Asn Asp Pro Asn 
                 85                  90                  95
Ala Gln Gly Asp Ala Phe Lys Thr Leu Phe Val Ala Arg Val Asn Tyr 
             100                105                110
Asp Thr Thr Glu Ser Lys Leu Arg Arg Glu Phe Glu Val Tyr Gly Pro 
         115                120                125
Ile Lys Arg Ile His Met Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg 
     130                135                140
Gly Tyr Ala Phe Ile Glu Tyr Glu His Glu Arg Asp Met His Ser Ala 
 145                150                155                160
Tyr Lys His Ala Asp Gly Lys Lys Ile Asp Gly Arg Arg Val Leu Val 
                 165                170                175
Asp Val Glu Arg Gly Arg Thr Val Lys Gly Trp Arg Pro Arg Arg Leu 
             180                185                190
Gly Gly Gly Leu Gly Gly Thr Arg Arg Gly Gly Ala Asp Val Asn Ile 
         195                200                205
Arg His Ser Gly Arg Asp Asp Thr Ser Arg Tyr Asp Glu Arg Pro Gly 
     210                215                220
Pro Ser Pro Leu Pro His Arg Asp Arg Asp Arg Asp Arg Glu Arg Glu 
 225                230                235                240
Arg Arg Glu Arg Ser Arg Glu Arg Asp Lys Glu Arg Glu Arg Arg Arg 
                 245                250                255
Ser Arg Ser Arg Asp Arg Arg Arg Arg Ser Arg Ser Arg Asp Lys Glu 
             260                265                270
Glu Arg Arg Arg Ser Arg Glu Arg Ser Lys Asp Lys Asp Arg Asp Arg 
         275                280                285
Lys Arg Arg Ser Ser Arg Ser Arg Glu Arg Ala Arg Arg Glu Arg Glu 
     290                295                300
Arg Lys Glu Glu Leu Arg Gly Gly Gly Gly Asp Met Ala Glu Pro Ser 
 305                310                315                320
Glu Ala Gly Asp Ala Pro Pro Asp Asp Gly Pro Pro Gly Glu Leu Gly 
                 325                330                335
Pro Asp Gly Pro Asp Gly Pro Glu Glu Lys Gly Arg Asp Arg Asp Arg 
             340                345                350
Glu Arg Arg Arg Ser His Arg Ser Glu Arg Glu Arg Arg Arg Asp Arg 
         355                360                365
Asp Arg Asp Arg Asp Arg Asp Arg Glu His Lys Arg Gly Glu Arg Gly 
     370                375                380
Ser Glu Arg Gly Arg Asp Glu Ala Arg Gly Gly Gly Gly Gly Gln Asp 
 385                390                395                400
Asn Gly Leu Glu Gly Leu Gly Asn Asp Ser Arg Asp Met Tyr Met Glu 
                 405                410                415
Ser Glu Gly Gly Asp Gly Tyr Leu Ala Pro Glu Asn Gly Tyr Leu Met 
             420                425                430
Glu Ala Ala Pro Glu 
         435



<210> 5413
<211> 438
<212> DNA
<213> Rattus norvegicus
<308> AA891322
<400> 5413

aacaggaaa  taattttat  cttaaatcc  agggatcag  acaaaaaac  tctgccctc  60
aagggcaag  caaggtgga  aggctagga  ggcagacag  aaggcagga  catgtccac  120
acagaggcc  cttcattca  gcgctgcct  catcagaaa  aatttctct  gggccatgt  180
cccatcccc  ccctcggcc  ccatgtaca  gtctcgacc  tcactacct  gcccttcca  240
cccattgtc  tgaccgctc  cacccccac  ccgggcctt  cctgccccg  tcactgccc  300
gctccccac  cttgtgctc  ctatcccgg  cacggtctc  gtctcgacg  cgttccctc  360
cacttcggt  acttcgacg  ctctcccgg  ctcgatccc  acccttctc  tcagggnca  420
canggcctt  aaggccaa  438



<210> 5414
<211> 1672
<212> DNA
<213> Homo sapiens
<308> X06815
<400> 5414

gcgctcgct  agcgggcga  ggaatcaga  ggacgtgga  gcccccgga  tggaagccg  60
agcaggagt  gttgttgct  aggggctgc  gcagccgcc  cgagcctcc  gacagacgc  120
agagcgagg  ggcgctacg  gacttggca  gatgaccca  ttcctgccg  ccaaccttc  180
ggccctctt  gccccccgt  accctattc  atacctgcc  cccctggag  aactgccac  240
tgaaaaaca  cacaatcaa  cttattgtg  cattgcgcc  tacattcga  agtttgagg  300
ccctcgaga  gcccctcct  caactcgtg  tgaaacccg  gaggagcgc  tggagagga  360
aagacggga  aagattgag  ggcgacagc  agaagtgga  acagagctt  aaatgtggg  420
ccctcacaa  gatcccaat  ctcaggggg  tgccttcaa  actctcttc  tggcgagag  480
gaattatga  acaacagaa  ccaagctcc  gagagagtt  gaggtgtac  gacctatca  540
aagaataca  atggtctac  gtaagcggt  aggaaagcc  cgtggctat  ccttcatcg  600
gtacgaaca  gagcgagac  tgcactcca  cacgcagct  gcttgcagc  gatgcttac  660
ctcccctta  aacacctca  tgtatggtt  gtataaggc  gcttacaaa  acgcagatg  720
caagaagat  gatggcagg  gggtccttg  ggacgtgga  aggggccga  ccgtgaagg  780
ctggaggcc  cggcggcta  gaggaggcc  cggtggtac  agaagagga  gggctgatg  840
gaacatccg  cattcaggc  gcgatgaca  ctcccgcta  gatgagagg  accgggacc  900
ggaccgtga  cgggagcgc  gagagcgga  ccgggagcg  gacaaggag  gagaacggc  960
acgctcccg  tcccgggac  ggcggaggc  ctcacggag  cgcgacaag  aggagcgga  1020
gcgctccag  gagcggagc  aggacaagg  ccgggaccg  aagcggcga  gcagccgga  1080
tcgggagcg  gcccggcgg  agcgggagc  caaggagga  ctgcgtggc  gcggtggcg  1140
catggcgga  ccctccgag  cgggtgacg  gccccctga  gatgggcct  caggggagc  1200
cgggcctga  ggccctgac  gtccagagg  aaagggccg  gatcgtgac  gggagcgac  1260
gcggagcca  cggagcgag  gcgagcggc  ccgggaccg  gatcgtgac  gtgaccgtg  1320
ccgcgagca  aaacggggg  agcggggca  tgagcgggg  agggatgag  cccgaggtg  1380
gggcggtgg  caggacaac  ggctggagg  tctgggcaa  gacagccga  acatgtaca  1440
ggagtctga  ggcggcgac  gctacctgg  tccggagaa  gggtatttg  tggaggctg  1500
gccggagtg  agaggtcgt  ctctccatc  gctgtgttt  gacgcgttc  tgcccagcc  1560
cttgctgtc  tcccctccc  caaccttgg  cacttgagt  tgtcctcca  gggtaggtg  1620
ctcatttgt  ctggcccct  ggatttaaa  ataaaatta  tttcctgtt  at  1672



<210> 5415
<211> 437
<212> PRT
<213> Homo sapiens
<308> Q9UE46
<400> 5415

Met Thr Gln Phe Leu Pro Pro Asn Leu Leu Ala Leu Phe Ala Pro Arg 
  1               5                  10                  15
Asp Pro Ile Pro Tyr Leu Pro Pro Leu Glu Lys Leu Pro His Glu Lys 
             20                  25                  30
His His Asn Gln Pro Tyr Cys Gly Ile Ala Pro Tyr Ile Arg Glu Phe 
         35                  40                  45
Glu Asp Pro Arg Asp Ala Pro Pro Pro Thr Arg Ala Glu Thr Arg Glu 
     50                  55                  60
Glu Arg Met Glu Arg Lys Arg Arg Glu Lys Ile Glu Arg Arg Gln Gln 
 65                  70                  75                  80
Glu Val Glu Thr Glu Leu Lys Met Trp Asp Pro His Asn Asp Pro Asn 
                 85                  90                  95
Ala Gln Gly Asp Ala Phe Lys Thr Leu Phe Val Ala Arg Val Asn Tyr 
             100                105                110
Asp Thr Thr Glu Ser Lys Leu Arg Arg Glu Phe Glu Val Tyr Gly Pro 
         115                120                125
Ile Lys Arg Ile His Met Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg 
     130                135                140
Gly Tyr Ala Phe Ile Glu Tyr Glu His Glu Arg Asp Met His Ser Ala 
 145                150                155                160
Tyr Lys His Ala Asp Gly Lys Lys Ile Asp Gly Arg Arg Val Leu Val 
                 165                170                175
Asp Val Glu Arg Gly Arg Thr Val Lys Gly Trp Arg Pro Arg Arg Leu 
             180                185                190
Gly Gly Gly Leu Gly Gly Thr Arg Arg Gly Gly Ala Asp Val Asn Ile 
         195                200                205
Arg His Ser Gly Arg Asp Asp Thr Ser Arg Tyr Asp Glu Arg Pro Gly 
     210                215                220
Pro Ser Pro Leu Pro His Arg Asp Arg Asp Arg Asp Arg Glu Arg Glu 
 225                230                235                240
Arg Arg Glu Arg Ser Arg Glu Arg Asp Lys Glu Arg Glu Arg Arg Arg 
                 245                250                255
Ser Arg Ser Arg Asp Arg Arg Arg Arg Ser Arg Ser Arg Asp Lys Glu 
             260                265                270
Glu Arg Arg Arg Ser Arg Glu Arg Ser Lys Asp Lys Asp Arg Asp Arg 
         275                280                285
Lys Arg Arg Ser Ser Arg Ser Arg Glu Arg Ala Arg Arg Glu Arg Glu 
     290                295                300
Arg Lys Glu Glu Leu Arg Gly Gly Gly Gly Asp Met Ala Glu Pro Ser 
 305                310                315                320
Glu Ala Gly Asp Ala Pro Pro Asp Asp Gly Pro Pro Gly Glu Leu Gly 
                 325                330                335
Pro Asp Gly Pro Asp Gly Pro Glu Glu Lys Gly Arg Asp Arg Asp Arg 
             340                345                350
Glu Arg Arg Arg Ser His Arg Ser Glu Arg Glu Arg Arg Arg Asp Arg 
         355                360                365
Asp Arg Asp Arg Asp Arg Asp Arg Glu His Lys Arg Gly Glu Arg Gly 
     370                375                380
Ser Glu Arg Gly Arg Asp Glu Ala Arg Gly Gly Gly Gly Gly Gln Asp 
 385                390                395                400
Asn Gly Leu Glu Gly Leu Gly Asn Asp Ser Arg Asp Met Tyr Met Glu 
                 405                410                415
Ser Glu Gly Gly Asp Gly Tyr Leu Ala Pro Glu Asn Gly Tyr Leu Met 
             420                425                430
Glu Ala Ala Pro Glu 
         435



<210> 5416
<211> 438
<212> DNA
<213> Rattus norvegicus
<308> AA891322
<400> 5416

aacaggaaa  taattttat  cttaaatcc  agggatcag  acaaaaaac  tctgccctc  60
aagggcaag  caaggtgga  aggctagga  ggcagacag  aaggcagga  catgtccac  120
acagaggcc  cttcattca  gcgctgcct  catcagaaa  aatttctct  gggccatgt  180
cccatcccc  ccctcggcc  ccatgtaca  gtctcgacc  tcactacct  gcccttcca  240
cccattgtc  tgaccgctc  cacccccac  ccgggcctt  cctgccccg  tcactgccc  300
gctccccac  cttgtgctc  ctatcccgg  cacggtctc  gtctcgacg  cgttccctc  360
cacttcggt  acttcgacg  ctctcccgg  ctcgatccc  acccttctc  tcagggnca  420
canggcctt  aaggccaa  438



<210> 5417
<211> 121
<212> PRT
<213> Rattus norvegicus
<308> AAH02169
<400> 5417

Met Ala Glu Pro Ser Glu Ala Gly Asp Gly Ala Pro Asp Asp Gly Pro 
  1               5                  10                  15
Pro Gly Glu Leu Gly Pro Glu Gly Pro Asp Gly Pro Glu Glu Lys Gly 
             20                  25                  30
Arg Asp Arg Asp Arg Glu Arg Arg Arg Ser His Arg Ser Glu Arg Glu 
         35                  40                  45
Arg Arg Arg Asp Arg Asp Arg Asp Arg Asp Arg Glu His Lys Arg Gly 
     50                  55                  60
Glu Arg Gly Ser Glu Arg Gly Arg Asp Glu Ala Arg Gly Gly Gly Gly 
 65                  70                  75                  80
Ser Gly Gln Asp Asn Gly Leu Glu Gly Leu Gly Ser Asp Gly Arg Asp 
                 85                  90                  95
Met Tyr Met Glu Ala Glu Gly Gly Asp Gly Tyr Met Ala Pro Glu Asn 
             100                105                110
Gly Tyr Leu Met Glu Ala Ala Pro Glu 
         115                120



<210> 5418
<211> 1672
<212> DNA
<213> Homo sapiens
<308> X06815
<400> 5418

gcgctcgct  agcgggcga  ggaatcaga  ggacgtgga  gcccccgga  tggaagccg  60
agcaggagt  gttgttgct  aggggctgc  gcagccgcc  cgagcctcc  gacagacgc  120
agagcgagg  ggcgctacg  gacttggca  gatgaccca  ttcctgccg  ccaaccttc  180
ggccctctt  gccccccgt  accctattc  atacctgcc  cccctggag  aactgccac  240
tgaaaaaca  cacaatcaa  cttattgtg  cattgcgcc  tacattcga  agtttgagg  300
ccctcgaga  gcccctcct  caactcgtg  tgaaacccg  gaggagcgc  tggagagga  360
aagacggga  aagattgag  ggcgacagc  agaagtgga  acagagctt  aaatgtggg  420
ccctcacaa  gatcccaat  ctcaggggg  tgccttcaa  actctcttc  tggcgagag  480
gaattatga  acaacagaa  ccaagctcc  gagagagtt  gaggtgtac  gacctatca  540
aagaataca  atggtctac  gtaagcggt  aggaaagcc  cgtggctat  ccttcatcg  600
gtacgaaca  gagcgagac  tgcactcca  cacgcagct  gcttgcagc  gatgcttac  660
ctcccctta  aacacctca  tgtatggtt  gtataaggc  gcttacaaa  acgcagatg  720
caagaagat  gatggcagg  gggtccttg  ggacgtgga  aggggccga  ccgtgaagg  780
ctggaggcc  cggcggcta  gaggaggcc  cggtggtac  agaagagga  gggctgatg  840
gaacatccg  cattcaggc  gcgatgaca  ctcccgcta  gatgagagg  accgggacc  900
ggaccgtga  cgggagcgc  gagagcgga  ccgggagcg  gacaaggag  gagaacggc  960
acgctcccg  tcccgggac  ggcggaggc  ctcacggag  cgcgacaag  aggagcgga  1020
gcgctccag  gagcggagc  aggacaagg  ccgggaccg  aagcggcga  gcagccgga  1080
tcgggagcg  gcccggcgg  agcgggagc  caaggagga  ctgcgtggc  gcggtggcg  1140
catggcgga  ccctccgag  cgggtgacg  gccccctga  gatgggcct  caggggagc  1200
cgggcctga  ggccctgac  gtccagagg  aaagggccg  gatcgtgac  gggagcgac  1260
gcggagcca  cggagcgag  gcgagcggc  ccgggaccg  gatcgtgac  gtgaccgtg  1320
ccgcgagca  aaacggggg  agcggggca  tgagcgggg  agggatgag  cccgaggtg  1380
gggcggtgg  caggacaac  ggctggagg  tctgggcaa  gacagccga  acatgtaca  1440
ggagtctga  ggcggcgac  gctacctgg  tccggagaa  gggtatttg  tggaggctg  1500
gccggagtg  agaggtcgt  ctctccatc  gctgtgttt  gacgcgttc  tgcccagcc  1560
cttgctgtc  tcccctccc  caaccttgg  cacttgagt  tgtcctcca  gggtaggtg  1620
ctcatttgt  ctggcccct  ggatttaaa  ataaaatta  tttcctgtt  at  1672



<210> 5419
<211> 437
<212> PRT
<213> Homo sapiens
<308> Q9UE46
<400> 5419

Met Thr Gln Phe Leu Pro Pro Asn Leu Leu Ala Leu Phe Ala Pro Arg 
  1               5                  10                  15
Asp Pro Ile Pro Tyr Leu Pro Pro Leu Glu Lys Leu Pro His Glu Lys 
             20                  25                  30
His His Asn Gln Pro Tyr Cys Gly Ile Ala Pro Tyr Ile Arg Glu Phe 
         35                  40                  45
Glu Asp Pro Arg Asp Ala Pro Pro Pro Thr Arg Ala Glu Thr Arg Glu 
     50                  55                  60
Glu Arg Met Glu Arg Lys Arg Arg Glu Lys Ile Glu Arg Arg Gln Gln 
 65                  70                  75                  80
Glu Val Glu Thr Glu Leu Lys Met Trp Asp Pro His Asn Asp Pro Asn 
                 85                  90                  95
Ala Gln Gly Asp Ala Phe Lys Thr Leu Phe Val Ala Arg Val Asn Tyr 
             100                105                110
Asp Thr Thr Glu Ser Lys Leu Arg Arg Glu Phe Glu Val Tyr Gly Pro 
         115                120                125
Ile Lys Arg Ile His Met Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg 
     130                135                140
Gly Tyr Ala Phe Ile Glu Tyr Glu His Glu Arg Asp Met His Ser Ala 
 145                150                155                160
Tyr Lys His Ala Asp Gly Lys Lys Ile Asp Gly Arg Arg Val Leu Val 
                 165                170                175
Asp Val Glu Arg Gly Arg Thr Val Lys Gly Trp Arg Pro Arg Arg Leu 
             180                185                190
Gly Gly Gly Leu Gly Gly Thr Arg Arg Gly Gly Ala Asp Val Asn Ile 
         195                200                205
Arg His Ser Gly Arg Asp Asp Thr Ser Arg Tyr Asp Glu Arg Pro Gly 
     210                215                220
Pro Ser Pro Leu Pro His Arg Asp Arg Asp Arg Asp Arg Glu Arg Glu 
 225                230                235                240
Arg Arg Glu Arg Ser Arg Glu Arg Asp Lys Glu Arg Glu Arg Arg Arg 
                 245                250                255
Ser Arg Ser Arg Asp Arg Arg Arg Arg Ser Arg Ser Arg Asp Lys Glu 
             260                265                270
Glu Arg Arg Arg Ser Arg Glu Arg Ser Lys Asp Lys Asp Arg Asp Arg 
         275                280                285
Lys Arg Arg Ser Ser Arg Ser Arg Glu Arg Ala Arg Arg Glu Arg Glu 
     290                295                300
Arg Lys Glu Glu Leu Arg Gly Gly Gly Gly Asp Met Ala Glu Pro Ser 
 305                310                315                320
Glu Ala Gly Asp Ala Pro Pro Asp Asp Gly Pro Pro Gly Glu Leu Gly 
                 325                330                335
Pro Asp Gly Pro Asp Gly Pro Glu Glu Lys Gly Arg Asp Arg Asp Arg 
             340                345                350
Glu Arg Arg Arg Ser His Arg Ser Glu Arg Glu Arg Arg Arg Asp Arg 
         355                360                365
Asp Arg Asp Arg Asp Arg Asp Arg Glu His Lys Arg Gly Glu Arg Gly 
     370                375                380
Ser Glu Arg Gly Arg Asp Glu Ala Arg Gly Gly Gly Gly Gly Gln Asp 
 385                390                395                400
Asn Gly Leu Glu Gly Leu Gly Asn Asp Ser Arg Asp Met Tyr Met Glu 
                 405                410                415
Ser Glu Gly Gly Asp Gly Tyr Leu Ala Pro Glu Asn Gly Tyr Leu Met 
             420                425                430
Glu Ala Ala Pro Glu 
         435



<210> 5420
<211> 438
<212> DNA
<213> Rattus norvegicus
<308> AA891322
<400> 5420

aacaggaaa  taattttat  cttaaatcc  agggatcag  acaaaaaac  tctgccctc  60
aagggcaag  caaggtgga  aggctagga  ggcagacag  aaggcagga  catgtccac  120
acagaggcc  cttcattca  gcgctgcct  catcagaaa  aatttctct  gggccatgt  180
cccatcccc  ccctcggcc  ccatgtaca  gtctcgacc  tcactacct  gcccttcca  240
cccattgtc  tgaccgctc  cacccccac  ccgggcctt  cctgccccg  tcactgccc  300
gctccccac  cttgtgctc  ctatcccgg  cacggtctc  gtctcgacg  cgttccctc  360
cacttcggt  acttcgacg  ctctcccgg  ctcgatccc  acccttctc  tcagggnca  420
canggcctt  aaggccaa  438



<210> 5421
<211> 1672
<212> DNA
<213> Homo sapiens
<308> X06815
<400> 5421

gcgctcgct  agcgggcga  ggaatcaga  ggacgtgga  gcccccgga  tggaagccg  60
agcaggagt  gttgttgct  aggggctgc  gcagccgcc  cgagcctcc  gacagacgc  120
agagcgagg  ggcgctacg  gacttggca  gatgaccca  ttcctgccg  ccaaccttc  180
ggccctctt  gccccccgt  accctattc  atacctgcc  cccctggag  aactgccac  240
tgaaaaaca  cacaatcaa  cttattgtg  cattgcgcc  tacattcga  agtttgagg  300
ccctcgaga  gcccctcct  caactcgtg  tgaaacccg  gaggagcgc  tggagagga  360
aagacggga  aagattgag  ggcgacagc  agaagtgga  acagagctt  aaatgtggg  420
ccctcacaa  gatcccaat  ctcaggggg  tgccttcaa  actctcttc  tggcgagag  480
gaattatga  acaacagaa  ccaagctcc  gagagagtt  gaggtgtac  gacctatca  540
aagaataca  atggtctac  gtaagcggt  aggaaagcc  cgtggctat  ccttcatcg  600
gtacgaaca  gagcgagac  tgcactcca  cacgcagct  gcttgcagc  gatgcttac  660
ctcccctta  aacacctca  tgtatggtt  gtataaggc  gcttacaaa  acgcagatg  720
caagaagat  gatggcagg  gggtccttg  ggacgtgga  aggggccga  ccgtgaagg  780
ctggaggcc  cggcggcta  gaggaggcc  cggtggtac  agaagagga  gggctgatg  840
gaacatccg  cattcaggc  gcgatgaca  ctcccgcta  gatgagagg  accgggacc  900
ggaccgtga  cgggagcgc  gagagcgga  ccgggagcg  gacaaggag  gagaacggc  960
acgctcccg  tcccgggac  ggcggaggc  ctcacggag  cgcgacaag  aggagcgga  1020
gcgctccag  gagcggagc  aggacaagg  ccgggaccg  aagcggcga  gcagccgga  1080
tcgggagcg  gcccggcgg  agcgggagc  caaggagga  ctgcgtggc  gcggtggcg  1140
catggcgga  ccctccgag  cgggtgacg  gccccctga  gatgggcct  caggggagc  1200
cgggcctga  ggccctgac  gtccagagg  aaagggccg  gatcgtgac  gggagcgac  1260
gcggagcca  cggagcgag  gcgagcggc  ccgggaccg  gatcgtgac  gtgaccgtg  1320
ccgcgagca  aaacggggg  agcggggca  tgagcgggg  agggatgag  cccgaggtg  1380
gggcggtgg  caggacaac  ggctggagg  tctgggcaa  gacagccga  acatgtaca  1440
ggagtctga  ggcggcgac  gctacctgg  tccggagaa  gggtatttg  tggaggctg  1500
gccggagtg  agaggtcgt  ctctccatc  gctgtgttt  gacgcgttc  tgcccagcc  1560
cttgctgtc  tcccctccc  caaccttgg  cacttgagt  tgtcctcca  gggtaggtg  1620
ctcatttgt  ctggcccct  ggatttaaa  ataaaatta  tttcctgtt  at  1672



<210> 5422
<211> 437
<212> PRT
<213> Homo sapiens
<308> Q9UE46
<400> 5422

Met Thr Gln Phe Leu Pro Pro Asn Leu Leu Ala Leu Phe Ala Pro Arg 
  1               5                  10                  15
Asp Pro Ile Pro Tyr Leu Pro Pro Leu Glu Lys Leu Pro His Glu Lys 
             20                  25                  30
His His Asn Gln Pro Tyr Cys Gly Ile Ala Pro Tyr Ile Arg Glu Phe 
         35                  40                  45
Glu Asp Pro Arg Asp Ala Pro Pro Pro Thr Arg Ala Glu Thr Arg Glu 
     50                  55                  60
Glu Arg Met Glu Arg Lys Arg Arg Glu Lys Ile Glu Arg Arg Gln Gln 
 65                  70                  75                  80
Glu Val Glu Thr Glu Leu Lys Met Trp Asp Pro His Asn Asp Pro Asn 
                 85                  90                  95
Ala Gln Gly Asp Ala Phe Lys Thr Leu Phe Val Ala Arg Val Asn Tyr 
             100                105                110
Asp Thr Thr Glu Ser Lys Leu Arg Arg Glu Phe Glu Val Tyr Gly Pro 
         115                120                125
Ile Lys Arg Ile His Met Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg 
     130                135                140
Gly Tyr Ala Phe Ile Glu Tyr Glu His Glu Arg Asp Met His Ser Ala 
 145                150                155                160
Tyr Lys His Ala Asp Gly Lys Lys Ile Asp Gly Arg Arg Val Leu Val 
                 165                170                175
Asp Val Glu Arg Gly Arg Thr Val Lys Gly Trp Arg Pro Arg Arg Leu 
             180                185                190
Gly Gly Gly Leu Gly Gly Thr Arg Arg Gly Gly Ala Asp Val Asn Ile 
         195                200                205
Arg His Ser Gly Arg Asp Asp Thr Ser Arg Tyr Asp Glu Arg Pro Gly 
     210                215                220
Pro Ser Pro Leu Pro His Arg Asp Arg Asp Arg Asp Arg Glu Arg Glu 
 225                230                235                240
Arg Arg Glu Arg Ser Arg Glu Arg Asp Lys Glu Arg Glu Arg Arg Arg 
                 245                250                255
Ser Arg Ser Arg Asp Arg Arg Arg Arg Ser Arg Ser Arg Asp Lys Glu 
             260                265                270
Glu Arg Arg Arg Ser Arg Glu Arg Ser Lys Asp Lys Asp Arg Asp Arg 
         275                280                285
Lys Arg Arg Ser Ser Arg Ser Arg Glu Arg Ala Arg Arg Glu Arg Glu 
     290                295                300
Arg Lys Glu Glu Leu Arg Gly Gly Gly Gly Asp Met Ala Glu Pro Ser 
 305                310                315                320
Glu Ala Gly Asp Ala Pro Pro Asp Asp Gly Pro Pro Gly Glu Leu Gly 
                 325                330                335
Pro Asp Gly Pro Asp Gly Pro Glu Glu Lys Gly Arg Asp Arg Asp Arg 
             340                345                350
Glu Arg Arg Arg Ser His Arg Ser Glu Arg Glu Arg Arg Arg Asp Arg 
         355                360                365
Asp Arg Asp Arg Asp Arg Asp Arg Glu His Lys Arg Gly Glu Arg Gly 
     370                375                380
Ser Glu Arg Gly Arg Asp Glu Ala Arg Gly Gly Gly Gly Gly Gln Asp 
 385                390                395                400
Asn Gly Leu Glu Gly Leu Gly Asn Asp Ser Arg Asp Met Tyr Met Glu 
                 405                410                415
Ser Glu Gly Gly Asp Gly Tyr Leu Ala Pro Glu Asn Gly Tyr Leu Met 
             420                425                430
Glu Ala Ala Pro Glu 
         435



<210> 5423
<211> 484
<212> DNA
<213> Rattus norvegicus
<308> AA891423
<400> 5423

actgtggct  aacagccac  attagcaac  ttaatataa  gtttttaat  caaagttca  60
cacaaagaa  gcagatgcc  tgcgtggag  cacgtggac  gcagctgcc  catcctcaa  120
tcccgggct  ctggtgttt  gtcctcgga  ccagcagtt  ccatgtgga  gctgcatgg  180
ctctgtcct  aacattgat  ccgtgggtc  tgaggtcct  gcggagtgc  tcacatgcc  240
ccagcaagg  ctgcctctc  tggagctgc  gtttccggg  ctccccggt  gccccaggc  300
tggccagtg  atactggcg  accttaagc  tgaagcgca  tagttcatc  accacacag  360
gcanggcta  tgtgctgct  tctcctgaa  cacactgtc  cttggccag  gaaatccaa  420
agtctcgaa  aactgctca  cgtaggcaa  gatggcccc  aacacagtg  gacttctcg  480
gcca  484



<210> 5424
<211> 552
<212> PRT
<213> Rattus norvegicus
<308> BAB26596
<400> 5424

Met Leu Arg Ala Arg Gly Pro Gly Pro Gly Ala Leu Leu Leu Arg Ala 
  1               5                  10                  15
Ala Leu Gly Leu Gly Arg Arg Gly Arg Ser Trp Gln Arg Pro Gln Gly 
             20                  25                  30
Gln Asp Thr Gly Val Gln Val His Asn Ser Leu Thr Gly Arg Lys Glu 
         35                  40                  45
Pro Leu Ile Val Ala Arg Ser Asp Ala Val Ser Trp Tyr Ser Cys Gly 
     50                  55                  60
Pro Thr Val Tyr Asp His Ala His Leu Gly His Ala Cys Ser Tyr Val 
 65                  70                  75                  80
Arg Phe Asp Ile Ile Arg Arg Ile Leu Thr Arg Val Phe Gly Cys Asn 
                 85                  90                  95
Val Val Met Ala Met Ser Ile Thr Asp Val Asp Asp Lys Ile Ile Lys 
             100                105                110
Arg Ala Asn Glu Met Asn Val Thr Pro Ala Ser Leu Ala Ser Leu Phe 
         115                120                125
Glu Glu Glu Phe Lys Gln Asp Met Ala Ala Leu Lys Val Leu Pro Pro 
     130                135                140
Thr Val Tyr Leu Arg Val Thr Glu Asn Ile Pro Gln Ile Ile Ala Phe 
 145                150                155                160
Ile Glu Gly Ile Ile Ala His Gly His Ala Tyr Ser Thr Ala Thr Gly 
                 165                170                175
Ser Val Tyr Phe Asp Leu His Ala Arg Gly Asp Lys Tyr Gly Lys Leu 
             180                185                190
Val Asn Thr Val Pro Ser Ala Thr Ala Glu Pro Ala Gly Asp Ser Asp 
         195                200                205
Lys Arg His Ser Ser Asp Phe Ala Leu Trp Lys Ala Ala Lys Pro Gln 
     210                215                220
Glu Val Phe Trp Ala Ser Pro Trp Gly Asp Gly Arg Pro Gly Trp His 
 225                230                235                240
Ile Glu Cys Ser Thr Met Ala Ser Glu Val Phe Gly Ser His Leu Asp 
                 245                250                255
Ile His Thr Gly Gly Ile Asp Leu Ala Phe Pro His His Glu Asn Glu 
             260                265                270
Ile Ala Gln Ser Glu Val Phe His Gln Cys Gln Gln Trp Gly Asn Tyr 
         275                280                285
Phe Leu His Ser Gly His Leu His Val Lys Gly Thr Glu Glu Lys Met 
     290                295                300
Ser Lys Ser Leu Lys Asn Tyr Ile Thr Ile Lys Asp Phe Leu Lys Thr 
 305                310                315                320
Phe Ser Pro Asp Val Phe Arg Leu Phe Cys Leu Arg Thr Asn Tyr Arg 
                 325                330                335
Ser Ala Ile Glu Tyr Ser Asp Ser Thr Leu Val Glu Ala Lys His Leu 
             340                345                350
Leu Leu Gly Leu Ala Ser Phe Val Glu Asp Ala Arg Ala Tyr Val Lys 
         355                360                365
Gly Gln Leu Thr Cys Gly Pro Val Glu Glu Asp Val Leu Trp Glu Arg 
     370                375                380
Leu Thr Ser Thr Lys Lys Ala Val Lys Ala Ala Leu Ala Asn Asp Phe 
 385                390                395                400
Asp Thr Pro Arg Ala Val Asn Thr Ile Leu Asp Leu Val His His Ala 
                 405                410                415
Asn Arg Gln Leu Arg Ala Val Ser Lys Glu Ala Ser Gly Pro Arg Ser 
             420                425                430
Pro Thr Val Phe Gly Ala Ile Thr Ser Tyr Val Glu Gln Phe Phe Glu 
         435                440                445
Thr Val Gly Ile Ser Leu Ala Asn Arg Gln Cys Val Ser Gly Asp Ser 
     450                455                460
Ser Thr Val Thr Leu Arg Cys Val Val Asp Glu Leu Val Arg Phe Arg 
 465                470                475                480
Leu Lys Val Arg Gln Tyr Ala Leu Asp Thr Pro Gly Ala Ala Gly Glu 
                 485                490                495
Ala Arg Lys Arg Gln Leu Gln Glu Arg Gln Pro Leu Leu Glu Ala Cys 
             500                505                510
Asp Thr Leu Arg Gln Asp Leu Val Thr His Gly Ile Asn Val Lys Asp 
         515                520                525
Arg Gly Ser Ala Ala Ser Thr Trp Glu Leu Leu Asp Pro Arg Thr Arg 
     530                535                540
His Gln Lys Pro Gly Asp Arg Gly 
 545                550



<210> 5425
<211> 1850
<212> DNA
<213> Homo sapiens
<308> BC007220
<400> 5425

ggccgctga  atgttgagg  ctacgcgcg  cccaggcct  ggccccccg  tgctccagg  60
cgcgctggg  cttgggcgg  ctgggtggc  ctggcctgc  ggccgggcg  cgagcgggg  120
gcgcgggcg  gcctggctg  agcccacgg  ccgggagac  ggtgtgcag  tgtacaaca  180
cctcaccgg  aggaaggaa  ccctaatcg  ggcgcacgc  gaagccgcc  cctggtata  240
ctgtggacc  actgtatat  atcatgcgc  ccttggcca  gcttgctca  atgttagat  300
tgatatcat  cgaaggatc  taaccaagg  ttttggatg  agcatagtc  tggtgatgg  360
tattacaga  gtagatgat  aaatcatca  aagagccaa  gagatgaat  tttcccccg  420
ttccctcgc  agtctttat  aggaagact  caagcagga  atggcagcc  tgaaggttc  480
cccacccac  gtgtacctg  gggtaaccg  aaatattcc  cagataatt  ctttcattg  540
aggaatcat  gctcgtggg  acgcttatt  aacggcaaa  ggcaatgtc  acttcgatc  600
gaagtctag  ggagacaag  atggcaaat  ggtcggcgt  gtccctggt  cagtcggag  660
gccagcgga  tctgacaag  gtcatgcca  tgacttcgc  ctgtggaag  cggccaaac  720
ccaggaggt  ttctgggcc  ctccctggg  acccgggag  ccgggctgg  acatcgagt  780
ctctgccat  gctagtatg  tatttggaa  tcaactgga  atccattca  gtgggatag  840
tttagcttt  ccacatcat  agaacgaaa  tgcacagtg  gaagtcttt  atcagtgcg  900
gcagtgggg  aattatttt  tgcattctg  gcatttgca  gccaaaggc  aagaagaaa  960
aatgtccaa  tcattaaag  actacatta  tattaagga  tttctgaag  ccttttccc  1020
cgatgtctt  cggttcttc  gcctgcgga  cagctaccg  tcagccatc  actacagtg  1080
cagcgccat  ctccaagct  agcagctgc  cctggggct  ggctctttc  tggaggacg  1140
acgtgccta  atgaagggg  agctggcct  cggctccgt  agggaagcg  tgctgtggg  1200
gaggctctc  agcaccaag  gggccgtga  ggcggcctt  gcagatgat  ttgacacac  1260
cagggtggt  gatgccatc  tgggccttg  acaccacgg  aatggacag  tcagggcgt  1320
cctgaagga  cctgaaggg  cgagaagtc  tgctgtgtt  ggtgccatc  tctcttact  1380
tgaacagtt  tttgaaact  ttggaattt  tctggcaaa  caacagtac  tttcaggag  1440
cggcagcga  gctaccttg  atggtgtgg  ggacgagct  gtgcggttc  ggcagaagg  1500
ccggcagtt  gcgctggcc  tgcccgagg  cacggggga  gcccggcgg  agcagctcc  1560
agaaaggca  cccctgctg  aagcatgcg  caccctgcg  cggggcctg  ctgcccacg  1620
catcaacat  aaggacaga  gcagtacaa  atccacgtg  gaactgctg  atccaagga  1680
aaaagacca  aaatcagcg  gctgaggat  gagcacagc  atgaacctg  tcacgacaa  1740
atgcaccca  gcttctcag  gtcaaggct  tatgttaaa  cttcctgtc  gggctgcta  1800
gtcagcatt  aagtaaggc  accaaaaaa  aaaaaaaaa  aaaaaaaaaa  1850



<210> 5426
<211> 564
<212> PRT
<213> Homo sapiens
<308> AAH07220
<400> 5426

Met Leu Arg Thr Thr Arg Gly Pro Gly Leu Gly Pro Pro Leu Leu Gln 
  1               5                  10                  15
Ala Ala Leu Gly Leu Gly Arg Ala Gly Trp His Trp Pro Ala Gly Arg 
             20                  25                  30
Ala Ala Ser Gly Gly Arg Gly Arg Ala Trp Leu Gln Pro Thr Gly Arg 
         35                  40                  45
Glu Thr Gly Val Gln Val Tyr Asn Ser Leu Thr Gly Arg Lys Glu Pro 
     50                  55                  60
Leu Ile Val Ala His Ala Glu Ala Ala Ser Trp Tyr Ser Cys Gly Pro 
 65                  70                  75                  80
Thr Val Tyr Asp His Ala His Leu Gly His Ala Cys Ser Tyr Val Arg 
                 85                  90                  95
Phe Asp Ile Ile Arg Arg Ile Leu Thr Lys Val Phe Gly Cys Ser Ile 
             100                105                110
Val Met Val Met Gly Ile Thr Asp Val Asp Asp Lys Ile Ile Lys Arg 
         115                120                125
Ala Asn Glu Met Asn Ile Ser Pro Ala Ser Leu Ala Ser Leu Tyr Glu 
     130                135                140
Glu Asp Phe Lys Gln Asp Met Ala Ala Leu Lys Val Leu Pro Pro Thr 
 145                150                155                160
Val Tyr Leu Arg Val Thr Glu Asn Ile Pro Gln Ile Ile Ser Phe Ile 
                 165                170                175
Glu Gly Ile Ile Ala Arg Gly Asn Ala Tyr Ser Thr Ala Lys Gly Asn 
             180                185                190
Val Tyr Phe Asp Leu Lys Ser Arg Gly Asp Lys Tyr Gly Lys Leu Val 
         195                200                205
Gly Val Val Pro Gly Pro Val Gly Glu Pro Ala Asp Ser Asp Lys Arg 
     210                215                220
His Ala Ser Asp Phe Ala Leu Trp Lys Ala Ala Lys Pro Gln Glu Val 
 225                230                235                240
Phe Trp Ala Ser Pro Trp Gly Pro Gly Arg Pro Gly Trp His Ile Glu 
                 245                250                255
Cys Ser Ala Ile Ala Ser Met Val Phe Gly Ser Gln Leu Asp Ile His 
             260                265                270
Ser Gly Gly Ile Asp Leu Ala Phe Pro His His Glu Asn Glu Ile Ala 
         275                280                285
Gln Cys Glu Val Phe His Gln Cys Glu Gln Trp Gly Asn Tyr Phe Leu 
     290                295                300
His Ser Gly His Leu His Ala Lys Gly Lys Glu Glu Lys Met Ser Lys 
 305                310                315                320
Ser Leu Lys Asn Tyr Ile Thr Ile Lys Asp Phe Leu Lys Thr Phe Ser 
                 325                330                335
Pro Asp Val Phe Arg Phe Phe Cys Leu Arg Ser Ser Tyr Arg Ser Ala 
             340                345                350
Ile Asp Tyr Ser Asp Ser Ala Met Leu Gln Ala Gln Gln Leu Leu Leu 
         355                360                365
Gly Leu Gly Ser Phe Leu Glu Asp Ala Arg Ala Tyr Met Lys Gly Gln 
     370                375                380
Leu Ala Cys Gly Ser Val Arg Glu Ala Met Leu Trp Glu Arg Leu Ser 
 385                390                395                400
Ser Thr Lys Arg Ala Val Lys Ala Ala Leu Ala Asp Asp Phe Asp Thr 
                 405                410                415
Pro Arg Val Val Asp Ala Ile Leu Gly Leu Ala His His Gly Asn Gly 
             420                425                430
Gln Leu Arg Ala Ser Leu Lys Glu Pro Glu Gly Pro Arg Ser Pro Ala 
         435                440                445
Val Phe Gly Ala Ile Ile Ser Tyr Phe Glu Gln Phe Phe Glu Thr Val 
     450                455                460
Gly Ile Ser Leu Ala Asn Gln Gln Tyr Val Ser Gly Asp Gly Ser Glu 
 465                470                475                480
Ala Thr Leu His Gly Val Val Asp Glu Leu Val Arg Phe Arg Gln Lys 
                 485                490                495
Val Arg Gln Phe Ala Leu Ala Met Pro Glu Ala Thr Gly Asp Ala Arg 
             500                505                510
Arg Gln Gln Leu Leu Glu Arg Gln Pro Leu Leu Glu Ala Cys Asp Thr 
         515                520                525
Leu Arg Arg Gly Leu Thr Ala His Gly Ile Asn Ile Lys Asp Arg Ser 
     530                535                540
Ser Thr Thr Ser Thr Trp Glu Leu Leu Asp Pro Arg Thr Lys Asp Gln 
 545                550                555                560
Lys Ser Ala Gly 
                 565



<210> 5427
<211> 481
<212> DNA
<213> Rattus norvegicus
<308> AA891445
<400> 5427

gccatgcca  agcaagggg  ctttattag  tgttcaggg  acagacagg  aggtggatg  60
tagatggtg  agcacacct  ctcggggtg  agtggtgcc  ggatgtcca  tttgtgggt  120
ttgctgtcc  tatcaatga  ctccagtcg  agtgtaggc  gacgctttt  agcctgggg  180
gagggcagc  cagggctct  gaggagctg  ttgtctgag  cctccacag  gatacgcag  240
gtgcagccc  ctggtagca  gtcctgctc  taggctgcc  ccagctggt  taccacacg  300
cgctctacc  catgcttaa  ggagcgggc  ccatagtgg  cgttgtagc  atcaaccaa  360
acgtctgcc  cctcgcggt  ccacagtag  gtgatgttg  gtctctgct  ggctctctt  420
gcccagaag  tcagttcct  gttgaccag  tggatgagc  ccgagtggc  caaagggag  480
a  481



<210> 5428
<211> 677
<212> PRT
<213> Rattus norvegicus
<308> NP_075236
<400> 5428

Met Met Leu Ser Ala Val Leu Arg Arg Thr Ala Pro Ala Pro Arg Leu 
  1               5                  10                  15
Phe Leu Gly Leu Ile Lys Ser Pro Ser Leu Gln Ser Arg Gly Gly Ala 
             20                  25                  30
Tyr Asn Arg Ser Val Ile Thr Gly Asp Arg Gly Glu Pro Gln Arg Leu 
         35                  40                  45
Arg Thr Ala Ala Trp Val Arg Pro Gly Ala Ser Ser Val Leu Phe Pro 
     50                  55                  60
Gly Arg Gly Ala Ala Thr Gly Gly Arg Arg Gly Glu Arg Thr Glu Ile 
 65                  70                  75                  80
Pro Tyr Leu Thr Ala Ala Ser Ser Gly Arg Gly Pro Ser Pro Glu Glu 
                 85                  90                  95
Thr Leu Pro Gly Gln Asp Ser Trp Asn Gly Val Pro Asn Lys Ala Gly 
             100                105                110
Leu Gly Met Trp Ala Leu Ala Met Ala Leu Val Val Gln Cys Tyr Asn 
         115                120                125
Lys Asn Pro Ser Asn Lys Asp Ala Ala Leu Met Glu Ala Ala Arg Ala 
     130                135                140
Asn Asn Val Gln Glu Val Arg Arg Leu Leu Ser Glu Gly Ala Asp Val 
 145                150                155                160
Asn Ala Arg His Lys Leu Gly Trp Thr Ala Leu Met Val Ala Ala Ile 
                 165                170                175
Ser His Asn Glu Ser Val Val Gln Val Leu Leu Ala Ala Gly Ala Asp 
             180                185                190
Pro Asn Leu Gly Asp Asp Phe Ser Ser Val Tyr Lys Thr Ala Asn Glu 
         195                200                205
Gln Gly Val His Ser Leu Glu Val Leu Val Thr Arg Glu Asp Asp Phe 
     210                215                220
Asn Asn Arg Leu Asn His Arg Ala Ser Phe Lys Gly Cys Thr Ala Leu 
 225                230                235                240
His Tyr Ala Val Leu Ala Asp Asp Tyr Ser Ile Val Lys Glu Leu Leu 
                 245                250                255
Gly Gly Gly Ala Asn Pro Leu Gln Arg Asn Glu Met Gly His Thr Pro 
             260                265                270
Leu Asp Tyr Ala Arg Glu Gly Glu Val Met Lys Leu Leu Lys Thr Ser 
         275                280                285
Glu Thr Lys Tyr Met Glu Lys Gln Arg Lys Arg Glu Ala Glu Glu Arg 
     290                295                300
Arg Arg Phe Pro Leu Glu Gln Arg Leu Glu Gln His Ile Ile Gly Gln 
 305                310                315                320
Glu Ser Ala Ile Ala Thr Val Gly Ala Ala Ile Arg Arg Lys Glu Asn 
                 325                330                335
Gly Trp Tyr Asp Glu Glu His Pro Leu Val Phe Leu Phe Leu Gly Ser 
             340                345                350
Ser Gly Ile Gly Lys Thr Glu Leu Ala Lys Gln Thr Ala Lys Tyr Met 
         355                360                365
His Lys Asp Ala Lys Lys Gly Phe Ile Arg Leu Asp Met Ser Glu Phe 
     370                375                380
Gln Glu Arg His Glu Val Ala Lys Phe Ile Gly Ser Pro Pro Gly Tyr 
 385                390                395                400
Ile Gly His Glu Glu Gly Gly Gln Leu Thr Lys Lys Leu Lys Gln Cys 
                 405                410                415
Pro Asn Ala Val Val Leu Phe Asp Glu Val Asp Lys Ala His Pro Asp 
             420                425                430
Val Leu Thr Ile Met Leu Gln Leu Phe Asp Glu Gly Arg Leu Thr Asp 
         435                440                445
Gly Lys Gly Lys Thr Ile Asp Cys Lys Asp Ala Ile Phe Ile Met Thr 
     450                455                460
Ser Asn Val Ala Ser Asp Glu Ile Ala Gln His Ala Leu Gln Leu Arg 
 465                470                475                480
Gln Glu Ala Leu Glu Met Ser Arg Asn Arg Ile Ala Glu Asn Leu Gly 
                 485                490                495
Asp Val Gln Ile Ser Asp Lys Ile Thr Ile Ser Lys Asn Phe Lys Glu 
             500                505                510
Asn Met Ile Arg Pro Ile Leu Lys Ala His Phe Arg Arg Asp Glu Phe 
         515                520                525
Leu Gly Arg Ile Asn Glu Ile Val Tyr Phe Leu Pro Phe Cys His Ser 
     530                535                540
Glu Leu Ile Gln Leu Val Asn Lys Glu Leu Asn Phe Trp Ala Lys Arg 
 545                550                555                560
Ala Lys Gln Arg His Asn Ile Thr Leu Leu Trp Asp Arg Glu Val Ala 
                 565                570                575
Asp Val Leu Val Asp Gly Tyr Asn Val Gln Tyr Gly Ala Arg Ser Ile 
             580                585                590
Lys His Glu Val Glu Arg Arg Val Val Asn Gln Leu Ala Ala Ala Tyr 
         595                600                605
Glu Gln Asp Leu Leu Pro Gly Gly Cys Thr Leu Arg Ile Thr Val Glu 
     610                615                620
Asp Ser Asp Lys Gln Leu Leu Lys Ser Pro Glu Leu Pro Ser Pro Gln 
 625                630                635                640
Ala Glu Lys Arg Pro Pro Thr Leu Arg Leu Glu Ile Ile Asp Lys Asp 
                 645                650                655
Ser Lys Thr His Lys Leu Asp Ile Gln Ala Pro Leu His Pro Glu Lys 
             660                665                670
Val Cys Tyr Thr Ile 
         675



<210> 5429
<211> 2307
<212> DNA
<213> Homo sapiens
<308> AL136909
<400> 5429

gtgcgcaac  ccaccctgt  cgcggcgtc  tcgaacgcg  cgcggcagc  atgttggac  60
tggtcagca  aggggccgg  accacgggg  tatcgaagc  gctgtcaag  tgctggggt  120
cctggtgtt  aggagaaaa  cactggcgc  acggctact  ctccggctg  tcaggtccc  180
aacgctccg  ggccatgga  gtgcttccg  ccggaatgt  actactggg  gtctcgggg  240
gccgcagtg  ctgagggta  ccaccgggg  gcgccctgg  acatcgccg  ccttgttct  300
cggacgtgg  gcagccacc  gggggcgcc  gggaggacg  ttcgatacc  aatgcctcg  360
ggctgccac  tggggacgc  ttcctggtc  cgaagaaac  ctcccagga  aggacagct  420
gaacggggt  cccagcagg  ccggactgg  catgtgcgc  ctggccgca  cgctggtgg  480
tcattgcta  agcaagagt  cgtccaaca  ggatgcagc  ctgttggaa  ctgcccgtg  540
caacaatat  caagaagtc  gcaggctgt  gtcagaagg  gcagatgtc  atgcaaagc  600
cagacttgg  tggacagca  tcatggtgg  agccatcaa  cgaaacaac  gtgtggtac  660
ggtcctgct  gctgctggg  ctgatccaa  ccttggaga  gatttcagc  gtgtttaca  720
gactgccaa  gaacaggga  tccattctt  ggaagatgg  ggacaggac  gtgcaagcc  780
gcacatcac  aaccagtgg  caagtgccc  ggagttcag  agatggcta  gactccccg  840
tggcgtcct  atcacccga  aggatgact  caacaacag  ctgaacaac  gcgccagtt  900
caagggctg  acggccttg  actatgctg  tcttgctga  gactaccgc  ctgtcaagg  960
gctgcttga  ggaggagcc  accccctgc  gaggaatga  atgggacac  cacccttgg  1020
ttatgcccg  gaaggggag  tgatgaagc  tctgaggac  tctgaagcc  agtaccaag  1080
gaagcagcg  aagcgtgag  ctgaggagc  gcgccgctt  cccctggag  agcgactaa  1140
ggagcacat  attggccag  agagcgcca  cgccacagt  ggtgctgcg  tccggagga  1200
ggagaatgg  tggtacgat  aagaacacc  tctggtctt  ctcttcttg  gatcatctg  1260
aataggaaa  acagagctg  ccaagcaga  agccaaata  atgcacaaa  atgctaaaa  1320
gggcttcat  aggctggac  tgtccgagt  ccaggagcg  cacgaggtg  ccaagttta  1380
tgggtctcc  ccaggctac  ttggccatg  ggagggtgg  cagctgacc  agaagttga  1440
gcagtgccc  aatgctgtg  tgctctttg  tgaagtaga  aaggcccat  cagatgtgc  1500
caccatcat  ctgcagctg  ttgatgagg  ccggctgac  gatggaaaa  ggaagacca  1560
tgattgcaa  gacgccatc  tcatcatga  ctccaatgt  gccagcgac  agatcgcac  1620
gcacgcgct  cagctgagg  aggaagctt  ggagatgag  cgtaaccgt  ttgccgaaa  1680
cctggggga  gtccagata  gtgacaaga  caccatctc  aagaacttc  aggagaatg  1740
gattcgccc  atcctgaaa  ctcacttcc  gagggatga  tttctggga  ggatcaatg  1800
gatcgtcta  ttcctcccc  tctgccact  ggagctcat  caactcgtc  acaaggaac  1860
aaacttctg  gccaagaga  ccaagcaaa  gcacaacat  acgctgctc  gggaccgcg  1920
ggtggcaga  gtgctggtc  acggctaca  tgtgcacta  ggcgcccgc  ccatcaaac  1980
tgaggtaga  cgccgtgtg  tgaaccagc  ggcagcagc  tatgagcag  acctgctgc  2040
agggggctg  actttgcgc  tcacggtgg  ggactcaga  aagcagcta  tcaaaagcc  2100
agaactgcc  tcaccccag  ctgagaagc  cctccccaa  ctgcgtctg  agatcatcg  2160
caaggacag  aagactcgc  gactggaca  ccgggcacc  ctgcaccct  agaaggtgt  2220
caacaccat  tagcagcca  ctgcctgct  ctatgtgcc  tcaccatcc  ataaaggcc  2280
cttggctgt  gcatggcaa  aaaaaaa  2307



<210> 5430
<211> 708
<212> PRT
<213> Homo sapiens
<308> AL136909
<400> 5430

Met Leu Gly Ser Leu Val Leu Arg Arg Lys Ala Leu Ala Pro Arg Leu 
  1               5                  10                  15
Leu Leu Arg Leu Leu Arg Ser Pro Thr Leu Arg Gly His Gly Gly Ala 
             20                  25                  30
Ser Gly Arg Asn Val Thr Thr Gly Ser Leu Gly Glu Pro Gln Trp Leu 
         35                  40                  45
Arg Val Ala Thr Gly Gly Arg Pro Gly Thr Ser Pro Ala Leu Phe Ser 
     50                  55                  60
Gly Arg Gly Ala Ala Thr Gly Gly Arg Gln Gly Gly Arg Phe Asp Thr 
 65                  70                  75                  80
Lys Cys Leu Ala Ala Ala Thr Trp Gly Arg Leu Pro Gly Pro Glu Glu 
                 85                  90                  95
Thr Leu Pro Gly Gln Asp Ser Trp Asn Gly Val Pro Ser Arg Ala Gly 
             100                105                110
Leu Gly Met Cys Ala Leu Ala Ala Ala Leu Val Val His Cys Tyr Ser 
         115                120                125
Lys Ser Pro Ser Asn Lys Asp Ala Ala Leu Leu Glu Ala Ala Arg Ala 
     130                135                140
Asn Asn Met Gln Glu Val Ser Arg Leu Leu Ser Glu Gly Ala Asp Val 
 145                150                155                160
Asn Ala Lys His Arg Leu Gly Trp Thr Ala Leu Met Val Ala Ala Ile 
                 165                170                175
Asn Arg Asn Asn Ser Val Val Gln Val Leu Leu Ala Ala Gly Ala Asp 
             180                185                190
Pro Asn Leu Gly Asp Asp Phe Ser Ser Val Tyr Lys Thr Ala Lys Glu 
         195                200                205
Gln Gly Ile His Ser Leu Glu Asp Gly Gly Gln Asp Gly Ala Ser Arg 
     210                215                220
His Ile Thr Asn Gln Trp Thr Ser Ala Leu Glu Phe Arg Arg Trp Leu 
 225                230                235                240
Gly Leu Pro Ala Gly Val Leu Ile Thr Arg Glu Asp Asp Phe Asn Asn 
                 245                250                255
Arg Leu Asn Asn Arg Ala Ser Phe Lys Gly Cys Thr Ala Leu His Tyr 
             260                265                270
Ala Val Leu Ala Asp Asp Tyr Arg Thr Val Lys Glu Leu Leu Asp Gly 
         275                280                285
Gly Ala Asn Pro Leu Gln Arg Asn Glu Met Gly His Thr Pro Leu Asp 
     290                295                300
Tyr Ala Arg Glu Gly Glu Val Met Lys Leu Leu Arg Thr Ser Glu Ala 
 305                310                315                320
Lys Tyr Gln Glu Lys Gln Arg Lys Arg Glu Ala Glu Glu Arg Arg Arg 
                 325                330                335
Phe Pro Leu Glu Gln Arg Leu Lys Glu His Ile Ile Gly Gln Glu Ser 
             340                345                350
Ala Ile Ala Thr Val Gly Ala Ala Ile Arg Arg Lys Glu Asn Gly Trp 
         355                360                365
Tyr Asp Glu Glu His Pro Leu Val Phe Leu Phe Leu Gly Ser Ser Gly 
     370                375                380
Ile Gly Lys Thr Glu Leu Ala Lys Gln Thr Ala Lys Tyr Met His Lys 
 385                390                395                400
Asp Ala Lys Lys Gly Phe Ile Arg Leu Asp Met Ser Glu Phe Gln Glu 
                 405                410                415
Arg His Glu Val Ala Lys Phe Ile Gly Ser Pro Pro Gly Tyr Val Gly 
             420                425                430
His Glu Glu Gly Gly Gln Leu Thr Lys Lys Leu Lys Gln Cys Pro Asn 
         435                440                445
Ala Val Val Leu Phe Asp Glu Val Asp Lys Ala His Pro Asp Val Leu 
     450                455                460
Thr Ile Met Leu Gln Leu Phe Asp Glu Gly Arg Leu Thr Asp Gly Lys 
 465                470                475                480
Gly Lys Thr Ile Asp Cys Lys Asp Ala Ile Phe Ile Met Thr Ser Asn 
                 485                490                495
Val Ala Ser Asp Glu Ile Ala Gln His Ala Leu Gln Leu Arg Gln Glu 
             500                505                510
Ala Leu Glu Met Ser Arg Asn Arg Ile Ala Glu Asn Leu Gly Asp Val 
         515                520                525
Gln Ile Ser Asp Lys Ile Thr Ile Ser Lys Asn Phe Lys Glu Asn Val 
     530                535                540
Ile Arg Pro Ile Leu Lys Ala His Phe Arg Arg Asp Glu Phe Leu Gly 
 545                550                555                560
Arg Ile Asn Glu Ile Val Tyr Phe Leu Pro Phe Cys His Ser Glu Leu 
                 565                570                575
Ile Gln Leu Val Asn Lys Glu Leu Asn Phe Trp Ala Lys Arg Ala Lys 
             580                585                590
Gln Arg His Asn Ile Thr Leu Leu Trp Asp Arg Glu Val Ala Asp Val 
         595                600                605
Leu Val Asp Gly Tyr Asn Val His Tyr Gly Ala Arg Ser Ile Lys His 
     610                615                620
Glu Val Glu Arg Arg Val Val Asn Gln Leu Ala Ala Ala Tyr Glu Gln 
 625                630                635                640
Asp Leu Leu Pro Gly Gly Cys Thr Leu Arg Ile Thr Val Glu Asp Ser 
                 645                650                655
Asp Lys Gln Leu Leu Lys Ser Pro Glu Leu Pro Ser Pro Gln Ala Glu 
             660                665                670
Lys Arg Leu Pro Lys Leu Arg Leu Glu Ile Ile Asp Lys Asp Ser Lys 
         675                680                685
Thr Arg Arg Leu Asp Ile Arg Ala Pro Leu His Pro Glu Lys Val Cys 
     690                695                700
Asn Thr Ile Ter 
 705



<210> 5431
<211> 969
<212> DNA
<213> Rattus norvegicus
<308> AJ400847
<400> 5431

ctctggact  ctgagcacc  cagtgtccc  agacagagc  tccttgcct  cctgatggc  60
ttgctgatc  cgcttcctg  agggactcc  gccatggct  aggtcctgc  tctgctctc  120
tcaggctgt  tgcatgctg  aaattcaga  agatacaac  gaaaaaatg  ctttggggt  180
aaccaacct  aacgctgct  tggagtcca  ggtggctcc  tcgacatcc  cttctcctt  240
tatttcccc  ggaagttgg  caaggatcc  cagatgagc  tagcctgga  atggaagga  300
ttccatggg  aagtcatct  caactcctc  ctgcctttc  tacatgagc  cttcaaggg  360
cggctcatc  tgaactgga  acagggtca  acatctgga  tcctcagaa  cctgaactt  420
aaggagtct  accaagccc  gtactttag  cgagttaat  tgcagtcga  agaaggcat  480
aagttgtgg  agtcaattc  tggaaccca  ctcaacgtg  cccaagcac  caacaccac  540
atgaggagc  ccttcatcg  cacctctga  ttcaccaca  ctggcctgg  gcacacaag  600
gaccagagg  atccttcac  gatgaacct  ggagccatg  tcacgatgc  cctggctaa  660
gttttggtc  tagtcctag  ctatggatg  atgatcttc  tgaggtgga  gcaaaggcc  720
gcacactaa  gcctaaacc  cagcaagaa  cagagctca  ggctgcagg  ttgtgctgt  780
aaacatcac  attcttgga  agacataga  gataacccc  acttctgcc  gactctgat  840
ctctctggg  tctgatatt  tctcctcag  agccaggtc  tactgtgtg  ctctgattc  900
caaagcctg  ctgtgctgt  ctctgtctg  tcatggagt  attaacact  tcaataaat  960
tcttactcc  969



<210> 5432
<211> 212
<212> PRT
<213> Rattus norvegicus
<308> AJ400847
<400> 5432

Met Ala Gln Val Leu Leu Leu Leu Ser Ser Gly Cys Leu His Ala Gly 
  1               5                  10                  15
Asn Ser Glu Arg Tyr Asn Arg Lys Asn Gly Phe Gly Val Asn Gln Pro 
             20                  25                  30
Glu Arg Cys Ser Gly Val Gln Gly Gly Ser Ile Asp Ile Pro Phe Ser 
         35                  40                  45
Phe Tyr Phe Pro Trp Lys Leu Ala Lys Asp Pro Gln Met Ser Ile Ala 
     50                  55                  60
Trp Lys Trp Lys Asp Phe His Gly Glu Val Ile Tyr Asn Ser Ser Leu 
 65                  70                  75                  80
Pro Phe Ile His Glu His Phe Lys Gly Arg Leu Ile Leu Asn Trp Thr 
                 85                  90                  95
Gln Gly Gln Thr Ser Gly Val Leu Arg Ile Leu Asn Leu Lys Glu Ser 
             100                105                110
Asp Gln Ala Gln Tyr Phe Ser Arg Val Asn Leu Gln Ser Thr Glu Gly 
         115                120                125
Met Lys Leu Trp Gln Ser Ile Pro Gly Thr Gln Leu Asn Val Thr Gln 
     130                135                140
Ala Leu Asn Thr Thr Met Arg Ser Pro Phe Ile Val Thr Ser Glu Phe 
 145                150                155                160
Thr Thr Ala Gly Leu Glu His Thr Ser Asp Gln Arg Asn Pro Ser Leu 
                 165                170                175
Met Asn Leu Gly Ala Met Val Thr Met Leu Leu Ala Lys Val Leu Val 
             180                185                190
Ile Val Leu Val Tyr Gly Trp Met Ile Phe Leu Arg Trp Lys Gln Arg 
         195                200                205
Pro Ala His Ter 
     210



<210> 5433
<211> 460
<212> DNA
<213> Rattus norvegicus
<308> AA891499
<400> 5433

cagcggaca  ccccagctc  ttgcaacgg  tggcaggag  agaggccga  gaggcagcg  60
ctgcggcgg  cgacgacag  aggaagcgg  gggcagcgg  ggcacagtc  tcggccgcc  120
gggccgcgt  gcgcggctc  aggtgctgc  agggggagg  ggcgtaggc  gtgtcccgc  180
gcagcggcg  cgacagcgg  ggctcctcc  ctgggccgg  gggggcggg  ccgccgggg  240
tgtgcacga  gaagcagag  atgcagggc  cgcggaaga  gcagtcccg  ttgcgggcc  300
ccgccgcgg  ctgtgggga  gacttggtc  gcgtccggc  cggcagtcg  atgagaggg  360
gccggcggc  acaccagct  cagcaacga  gcttcttct  gctcgcacg  ttccgaggc  420
ccttcgaaa  aagtggccc  taaagacgg  tttgggcccg  460



<210> 5434
<211> 31737
<212> DNA
<213> Homo sapiens
<308> AC008462
<400> 5434

aagctttac  tctaataac  gaaacaaga  atgatgccc  tttatgcca  ttctactta  60
catagtact  aaagttata  ccagagaaa  tagagggga  aaaaagaaa  gaaagacat  120
taaattaga  aggaagaga  aaaattatc  ctgttcaca  atgacatga  attgtaaat  180
gaagaccct  aaggttcca  atacaaaag  actattata  taaatgact  cagcaaagt  240
gtagaataa  aaaaaaaca  aaaaaatca  gtgcatttc  aaacactta  aaggaacaa  300
ctgaaaaag  aattaagag  actattcaa  ttacagtag  atcaaaagg  gtaaaattc  360
taggaataa  cttaaagga  gcaaaagac  tatacactg  aaattacaa  atatcactg  420
aagaaatta  agacacaaa  agatggaaa  aaatcccgt  ttaatgaat  ggaatactt  480
atattgtta  aatgtctat  ctactcatt  caatataca  gttcaatac  atccctatc  540
aaatctgaa  ggcattttt  gcagaaaaa  aaaaactca  cctaaaact  atatggaat  600
taaggacca  aaatagcca  aacaatctt  aaaaagaag  atccactgg  agtcccaca  660
ttcctgatt  caaaactta  cacaaagct  cagtaatac  aaaagcgta  tgctggcaa  720
aagacagac  tagaccaaa  gaaacaatc  agaaacaaa  tcttgcata  aaagtcaaa  780
tatttccta  aagggtgcc  gcactattc  gtggggaaa  ggcagcctt  tcaacaaat  840
gtgctggga  actggatat  tacatgcaa  tgaatgaag  tggaccttt  ccttgatcc  900
tatgttaaa  attacctaa  aatgaacgg  agacctaaa  catatgaat  aaaactata  960
aactcttag  aggaaaggt  ggataaaag  tttacaacg  tgaatttgg  aatatttct  1020
agttttgac  ccaaaagca  aggcaacaa  agtaaaaat  tatgttaaa  tacataaaa  1080
ttttaataa  ttctgtgca  tataggaca  aacagaaag  caaggaaac  tatggaatg  1140
gataaaata  ttgcaaatc  ttatttgat  aggagttaa  atctgaaac  tacacaaag  1200
actcctaca  ctcaacaat  aaataaccc  attttaaaa  gagtaatgt  ttagaagag  1260
catttatcc  aagatacgt  aatggccaa  aaaagcaca  gaaaacatg  ttagcgaca  1320
gaatcatta  ggagatgca  atcaaaaca  agaaatata  cctcacatc  attaagatg  1380
ctactataa  aataaataa  taaacaaac  gaaaataac  agtgtcagc  aggatgtgg  1440
gaaattaga  tccttgggc  ctgttgggt  aaatgtaaa  tggtgcgac  actatgtaa  1500
acagtatgg  agctcctaa  aatattaaa  atagaatta  attaagatc  agtaatttt  1560
cttctggat  tatacccca  agaactgaa  gaagggtct  aaagacatt  ttgtatacc  1620
atgttcata  cgttactta  aatagccaa  aagtggaag  aacccaact  tctatcaat  1680
gatgaatgg  taaacaaaa  gtggtgtgt  tatgtatat  tatgtgtgt  tgtgtgtgc  1740
tgcacatgt  cacacatac  caatgtaat  ttactcagc  tatagaagg  ggaaaattc  1800
aacacatgc  acaacatag  tgaatcttg  gggcattaa  ctaaatgaa  taagccagt  1860
atgaaaagg  aatgctgtg  gattataat  aataatctg  aaaagaaat  aaggtacct  1920
gaagaggta  ctagaggaa  caaagtcag  aaggcagaa  ataggtacc  agaggagtc  1980
aagtcacaa  gacacaaag  agaatggtg  ttttcagga  ctggaggaa  agcagtgta  2040
tgttgttta  tgggtataa  gttcagttt  gcaagataa  gagagtttt  gagactggt  2100
acacaacac  gtgaatgta  tcaccgtca  taaactgaa  acttaaaaa  gggtaagat  2160
gtaaatttt  tgttatata  attttacca  aattatttt  ttatttaag  gataaaaaa  2220
ctgatagaa  ggcacaaac  tgccacgta  cgccatcaa  ttcagtcaa  gaagaaaag  2280
gtgatcaac  aagaagtat  atctttgta  tcaaaactt  accaagtaa  tagaatgca  2340
gaattctta  ctcaaggag  aaacaattc  aagggcaca  aaatatagt  tctgtgaaa  2400
attcagcta  gtaagttgg  caaaaattt  atcttaaga  taaatggaa  acttgaaaa  2460
taagtggga  ttattttag  aagagaaaa  gggatactt  ttcaggaaa  agtataaac  2520
aaggtagaa  ctgtgaaaa  taagaagaa  gggaaaaag  aatattaac  tagcaggtc  2580
cacctcacc  tctataata  agcttaaat  agttcttaa  caggaaagc  atgttattg  2640
aaaacagta  ataccctat  tgtctggaa  tggatcata  gtacaccta  aagtcgtgg  2700
atctgacaa  cctaaggag  tgctattgc  gttcagaaa  acataaaag  gttaggatt  2760
gagtcagaa  tagaaacag  aaagcaagg  atcaaccta  ggaaacaag  cagtaataa  2820
gacaggtga  atacagggg  tagaagtga  caagacata  gcaatagct  acattttct  2880
gcctacaaa  ccaaaagac  ctactcatt  aaaaattac  tttgagcaa  taccatgtg  2940
ccaacactc  tctagacag  ggacataga  aggaacaag  aagataatc  ccccatttc  3000
actgagttt  cactttaag  gtggaacat  ataaacaaa  aataacaga  aaaaacaac  3060
gatactatc  gaagatttt  gacaagacc  aaaagccct  accattaat  aattgagct  3120
catcaaagt  aaaaccttg  tctcttcaa  agactctat  aaaacgaaa  gatacacac  3180
tagaaaaag  aatcacaat  catacatct  acacaagaa  ttatatcaa  aatatagaa  3240
tcttataac  tgtaagaag  caaccaatt  aaaaaaaat  ggcagaaga  ttggctggg  3300
gcagtggct  acatctgta  tcacagcac  ttgtgaggc  gaggcaggc  gataacctg  3360
ggcaagaag  tcaagacca  cctggccaa  atggtgaaa  cctgtctct  ctaaaaata  3420
aaattaaaa  aaaaatgag  tgggcatgg  ggtgcacgc  tgtaatccc  gctactcag  3480
aggctgagg  aggagaatc  cttaaactc  ggaggtgga  gttgtagtg  gccaagaac  3540
tgacactgc  ctccagcct  ggtgacaga  cgacagagc  agactctgt  tccaaaaaa  3600
agcaaaaga  ttgaaaaga  actttacaa  agaagagat  ggaaagcct  atacatatg  3660
taaaaggta  tcaatatca  tagacacag  gctaaccaa  taaggtacc  ccatacact  3720
actgagagt  aaaaccaca  taaggtacc  ctacacacc  actcagaat  gctaaaatt  3780
aaaaatcta  aaataacac  acctgttgg  agcgacata  tagtccaaa  ggagttctc  3840
aacattgct  gcaggagta  aaaatggca  aaccacctg  aaaactcat  atttctcac  3900
aagttcaag  taaacatac  cttcccaaa  aactcagcc  actcattcc  taaaattta  3960
tcaagagaa  tgaaagctt  tgtccattc  aagactggt  catgtatgt  cacagcagc  4020
ttatatgaa  tacttaaaa  ctggaaaca  ctgaaatgt  cattaacag  taaatggat  4080
agcacattg  tttatgtcc  tacaatgga  tgctattca  caataaaaa  gcaataaac  4140
atgatatac  tacaatact  acctaggaa  tgttgtcaa  aatctttga  ccagaagta  4200
atccagact  agactaagg  tgacataag  gaaagctaa  ccaaaagtc  aaaagaact  4260
gctccctaa  tgtactgtg  agacaatga  ttaactcaa  cctaaagcc  gaactacac  4320
ccagcacat  tcagttata  gccagtaac  ttcttattg  ttaagcaaa  tgacttgag  4380
tttctgcaa  aagaaaatt  cagattata  gatgtagtt  atatttaat  atttcaata  4440
ttgccattt  atagtaaga  gatttaact  caaagaatg  agattcatg  caaagaaaa  4500
gatagacac  aagacaaaa  aaatgaatg  actggaaca  ccactgtgg  tatgttact  4560
ggagtaaaa  atataaaag  tgtaacaag  gtaggcaga  ttttgaaaa  aacaagcaa  4620
cactaagat  aaatatgac  cttccagaa  ttcccaaga  gaaaggcta  ctgaacctc  4680
aatacataa  gcaaccatt  gttactttt  ccccttgct  agctctcag  aagaacagc  4740
ttcactacc  acaaagctc  ggcaataat  ccaggtttc  tttggtcat  aagaagaga  4800
aagaaaaac  gcagttggg  agttaacaa  agggaggct  acatttgtg  acaactatt  4860
cccaagatg  tttgttgga  agttcacat  cacagagtt  atttaatct  ctcaacaaa  4920
tagattata  cgtctccaa  ctatacatt  aaaaaatca  gatccaagg  gcttaaatg  4980
ttaagaagg  acctgcaat  tgtaaaatg  ttaatattg  tgttggaat  tatatctgt  5040
tgacacaaa  actatcttc  cacaaacca  ttgatgagg  taaacacca  gaagtttgt  5100
actgtgtgt  cctttgtct  gcctggcct  aaggaaagc  ttagttact  cccaaaaga  5160
aaatatgct  actaatgat  tgaccaagt  tatagtatt  aacattatt  aaagtatct  5220
aagcctgtt  attcttatc  ctgactcca  gtattaaac  atttggtgg  ctcagagaa  5280
gacagcagg  gacatgggc  ttatttaaa  aaaataaac  aaaacacta  gaatggaga  5340
gaagagaag  atgtagaaa  acgtgcctc  tggtttcat  aaaattatc  acaagataa  5400
ataaaaagg  caggagaat  tgaaaatat  ttcttctga  agaaaacca  caaaattta  5460
ggctattgt  tgtgatggg  aaaaatgaa  agagccata  tacccatca  taatgaagt  5520
ttgtagaag  gaaaatgca  tataatttt  gaaaatagg  acagataca  gcatgttgg  5580
atgtgtatt  aaagttttc  gaaaataat  accagagga  ttagcagga  gctttcagt  5640
tttattttc  acttttcta  actattaga  ttttataat  tgcactttt  tttatgaga  5700
caaggatta  ttgggcctc  ttcttatat  tctcaatat  ttgtaaaat  aacccaagt  5760
tatactttt  aattatgaa  agctttcaa  atttatcaa  agttttgac  ggtaactga  5820
tgaagagat  ctctaacta  tcatttaac  tgtgactaa  acttttaca  atacctgac  5880
taatcctaa  gtaataatg  tattcttat  ccataaatg  gaaaaccac  tcagagtca  5940
ttgctaagg  tcactcaac  aagagacag  ggtaattat  tatcctttg  tcttcccaa  6000
tcaagctcc  aggtgcttt  cattatacc  caattgcct  tgcaaacaa  aaggtattt  6060
aaagttaaa  tatacttat  taagaactt  tgtttatat  taggtatat  ttgtctctt  6120
ccaaaaaga  attgaggca  ctctttctg  aaataaacc  tacaggaga  acacaagta  6180
aaataaaaa  taaggaaaa  ggaaaaaga  gcattttcc  aaaagttat  ctataataa  6240
gatggaagt  ctgaatact  tgccttaga  ggactacca  ttgtttctt  gtttcttag  6300
tgtcaaagc  aagaggaaa  ggacaacta  acttcttta  taaaattca  agcattatc  6360
taataaaag  aaacaactg  ttaaagtct  gctttccct  gtattaaga  cagggggaa  6420
acttaactg  aggttctcg  aagggagga  tcataggat  cagtggaca  tgtccttaa  6480
aataaataa  catcaactc  atagaataa  gccaaaact  aattcactt  atttaattc  6540
tcaagtact  gtacctatg  attacccaa  tactaccat  gctcaatga  ataagtctt  6600
aacagcaaa  tacctttat  aaaaattat  agaacaagt  attgtaatg  gtacaccac  6660
ttatatact  taaaatagc  tctttaact  taatcttca  aatatttca  ttgaagatg  6720
aataactta  aagttatca  tagtaaaat  agtattaca  aagtgacat  cctttcaaa  6780
tcttactct  aaaacacag  atacaatat  tgagaggtt  acagtccag  ctcgggaac  6840
gtggctttg  taccaggtg  tactgtctt  cccagcaag  acttagata  gtaaataca  6900
cataatagg  aattactcc  attagttaa  agttactat  aaatcagta  accagcatg  6960
cctatggaa  agggtctgg  atcatactg  ttcatatgt  gttagtatt  aataaatac  7020
taatgcatg  gagaacaat  ggctatggg  ttacaaaaa  ataactgaa  catatagct  7080
ataaccatg  agtagccaa  gactacttt  tggatccag  atcatacta  ctgtaacaa  7140
agaatcatg  atgccctag  tttcaatat  gttttctag  gtataaaat  atgtcacac  7200
actatcaaa  ctgtttctt  tcccaaata  cataaagaa  tgactgcta  gaaccacgt  7260
ataactttt  tccattaaa  tattcaaat  actgatcta  atcgagaaa  gccaatcag  7320
tataccatt  tatctttaa  aaattattt  atattgttt  aaaaagtat  caagggatt  7380
ctgtttagg  ccttcatat  tttaaaaca  cactgaata  acttcaatg  aattaatta  7440
gtgaaactt  tcaaactac  acccaaaac  ttctaggcc  actgtttta  taataattc  7500
taagcaatc  caccaagat  tattttaaa  aacacacac  aatcaacaa  tatagattt  7560
ctagaacac  tcgtaaagc  aagaagtat  gtcgcaata  aaagtacca  gggaacaaa  7620
aaaactccc  ttctaataa  ctcacacta  caccttata  tgttttata  atacacaca  7680
acacatcat  atcacaggt  cacacacat  atcacacgt  cacacacat  atcacacat  7740
cacacacat  attgcacgt  cacacacat  catatgccc  catgagctt  ccacttaga  7800
gacaatctc  taaagattg  gactggtac  aacatgtat  ctatatcct  atgaaacct  7860
gtctctact  aaaatacaa  aaaaattag  tgggcatgg  ggcgggcac  tgtagtccc  7920
gctactcag  aggctgagg  aggactgtc  cttgaaccc  ggaggcgga  gctgcaatg  7980
gccgagact  cgccactgc  ctacagcct  ggcgacaga  caagactcc  tctcaaaaa  8040
aaatgtatt  tatatccta  aaccttata  atacaattg  tcataactt  ttcaaaagg  8100
aaaaatcta  tgttgtcaa  gttaaaaag  gctaatttg  tctccaaca  aattttatc  8160
attagttca  tcaatatca  gaaatcatt  accattcta  gtaccgact  ttcttagtt  8220
caaccaacc  catttccaa  ggactgcat  agtatgaag  cagatatga  cacacattt  8280
ttattttac  cagacttca  gttaaaaat  gaaactgga  aaaactcca  ctgtagtga  8340
agcaaatat  ctgtttggt  tgatttcac  aaaactgtg  acgagataa  tactaagct  8400
ctgaccaat  aactaagct  ttacagaaa  agaaagact  atgtttctt  caaattggt  8460
gttttgaaa  ccaagtctt  aaatcaaca  gaatattta  tgtggtttt  ccatttttc  8520
cctttaaag  tgttattaa  tcaatagca  ttctagcaa  caaagaaat  tagtgcaat  8580
attttatcc  tatgaaaaa  tacaatggc  gaacttatt  atgacacta  acattgata  8640
gtaaaacat  aaagtcatt  ggtaagcaa  aaattcact  atttccatt  caaactggg  8700
aatggctag  cattcctga  caactacac  cgtcaccta  cagagtaac  cttctaacc  8760
gtatatcaa  tcacaggaa  tgctaaaat  gcaacaaat  aaaactgaa  aaaaagacc  8820
cgttatcca  atttatgaa  ataacttat  aatgaaaaa  gcaaattca  gggaccaac  8880
tatagatac  acatattca  tctaaagat  tgaaataat  tgatgtgaa  atatagtag  8940
gaatatctt  aaagttaga  tcgaatagt  tcaaccagt  catcaaaat  acctcctta  9000
aaacttatt  gattaaaaa  tagtaaaaa  taaataatg  actgatcag  catatatac  9060
aatgtaaca  aatggaaag  atgataaac  taaaattca  gatagcagt  acctttgaa  9120
gggagtcaa  atgagagaa  ggaggaatg  ataggtaga  gaaagttat  gataatatt  9180
taattaata  tatggatgg  gcgttcctg  gtaaatgtt  aaaagcttt  tgataaatt  9240
acttttata  tgaaataag  ttatgcctg  accaattac  acagtatat  atgaaccaa  9300
gattgtaac  agtaaaatt  tatgttgcc  aggtccgtt  tgaaaaaaa  aatttatat  9360
tacttacag  aattcactt  ttataaatg  ttcctccta  cattaatat  aaaacatca  9420
caactccaa  ctttttaaa  aaatattca  attaaaaga  ggattatag  aattacctg  9480
gaaaaccaa  acaaaaatc  ttcttctcc  taaatcaga  taatactat  atattggtt  9540
caagttact  tccgtcaga  gtagttcag  acaaacttt  tgttttttg  tgttgttgg  9600
tttttctga  acagagtct  gctctgtca  ccaggctgg  gtgcagcgg  ttgatctca  9660
ctcactgca  cctccactt  ctgggttca  gcaatcttc  tgcctcagc  tcccaagta  9720
ctgggatta  ggttgtgca  catcatgtc  agctaattc  tgtattttt  gtagagatg  9780
agtttcgcc  tgtttgacc  ggctagttt  gaactcctg  cctcaagtg  tccaccgcc  9840
cggcctccc  aagtgctgg  attacaggc  tgagccaag  ggccagggc  aacatgtta  9900
caatgaaaa  caaaagcaa  agcaaaaaa  aaaaaaaaa  aaaaaaaga  tctatagtt  9960
aagattatg  aatgaatct  tattaagat  ttgtaattt  caaaaagct  caaaaatag  10020
tataaaatc  tatataaga  gttctaagt  aaactacct  aaaatgaaa  ccgaagcaa  10080
acatacaat  atttataag  aaattttgc  taagtcaaa  cagaaatac  agtatatat  10140
tatatatat  tatatacat  ttcaacata  tattctgaa  tttcccaag  ataaaatat  10200
tttatagct  acagtagtc  ataagacaa  tattaatgt  aagacaatg  aacataata  10260
atattgttt  atatttaca  ttccaaata  ataaaggaa  aagatgtaa  gttacctga  10320
agtatcaaa  ccaaacatg  gacttcatg  aaagatgga  agacaaatt  ctacgttaa  10380
aaatcactt  taaaatgct  aagtgctaa  attctttat  cctctgact  caaaacaag  10440
aatttcaaa  aaactctta  atccagagt  ttgaggaca  aatgactgt  aactattta  10500
gaacctgaa  aaaatgtgg  agtatttaa  atatcaaag  ttgagacac  gaaatctag  10560
agtggtcaa  tctttgctc  taatgtaaa  aaaaacaat  taactgaaa  ttttagaaa  10620
tgtcaattc  caatttatc  acacaggaa  ctaacaaaa  acaaaaata  catccttct  10680
gacttcagt  acatactct  aagatgaaa  ggcagggaa  aagaaccat  catacaaaa  10740
ccccaatga  attgtctct  taaattttc  ttcaattga  ttgattaga  agggttatc  10800
taaaagaaa  catagtaat  agtatttat  tgcaaagag  taattcaaa  ttattcaaa  10860
ttacttagt  aggtaactt  ccaaatttt  ccatgagga  acctgctac  tgccaagct  10920
agtactatg  actttatat  catcattat  ttttacaaa  gatctaatt  aagttacaa  10980
tagaagctt  agaaatgta  agtttgatg  cttgtaaag  ctgacctac  gtgctattg  11040
aaattgctt  ttagtagca  ttccaaata  atagtgata  caaagtcag  atgagtaca  11100
tttaatatt  tattcaaca  aatttctag  taattaagg  taaaaaata  ataaacacc  11160
aaattgccc  agaactagg  aatgaaaat  tctgtgctc  agttaagct  ccactctga  11220
ttctaattc  ctgtacatc  aagaaaatc  acttgccct  acacataag  actattccc  11280
tcagtgatc  ggcaggtgt  gaggccaga  agagagcct  ttttccaca  ccctttacc  11340
tgtttgatc  ctggttact  ttgatctga  actgccctc  gtctagtaa  gacttcccc  11400
tcatagacc  tacctcaca  ctgtcagaa  gaataaagg  catcaaact  agacctgac  11460
acgcctatg  gccatgcga  gtgctgcca  cagaatgtt  cccagctcc  acaattttc  11520
attcagttt  ttttgttct  gtaggtaga  ggttagggt  ccaatgaca  cagaaagga  11580
tatgaccaa  tgtgaaacc  agccttctt  aatgtgtat  ttttatttt  gcttcttca  11640
cttcttaaa  gctgcaaac  tcatggtgg  tactataaa  tacatattc  acaagtgca  11700
tagaaagtt  gtttaaaat  cttttccag  agaaaacaa  ggacacaat  cattgtaat  11760
caactataa  gctttaagg  aaaaatttc  aacccatgg  gtgagatta  taaaggccc  11820
ctgtcaaag  gcacgttaa  agtaaatga  accaccgaa  tcttacgcg  accacgact  11880
agtgggtac  gccattcac  gtctgaaaa  ggaaaagtc  cctaaaaca  cgtacatat  11940
tacaagaag  aatcatttc  attgttaaa  tacaaattc  acactattg  tgtgagaat  12000
aggtaaaat  aaaaataaa  tccactagt  ttgtttaaa  aatgtggtg  atatataca  12060
cctttttct  aaggcattg  tagtactag  ttttagatg  tagaaatta  aaaaatcag  12120
tcaaatatt  tggtatcat  ttactcata  tttttcaac  atcattaaa  cattttgag  12180
tcttgaata  aaatatttt  actctccca  tcccccacc  ccccccaac  cacaacaat  12240
tatggctca  tatcaggca  gcaataagg  gatttgcca  aaagcaggc  tagaggata  12300
tatgacttt  aaggttaag  cagtatctt  aaaaaaaaa  aatacgttt  ttttttaaa  12360
tttgaaaag  aggaccaga  gaggaaact  catgattat  agttacaag  aaatttaat  12420
taaatatag  attataatg  atacaaaca  ataacctta  acatgtact  atatagaag  12480
tcagagatg  agggtaagc  ctaaggtga  tacaagttg  ctccaataa  tggaagttc  12540
tttctacaa  agctgagaa  ggtatgcct  aacagaaag  gggaaggta  ccatgtcta  12600
agaattaac  tgtgacact  ggcaaatgc  cacactaga  tgaaaatga  ttaccacta  12660
tgaagatca  atgtgaaat  cctcctatt  ttatactga  cagcaatta  cataattat  12720
ttcttaaaa  aaccctgtt  ttgactgta  tctaaaaac  tgataacat  aagtatatt  12780
gaaaaatgt  attgtttta  atatatttt  atgtatgaa  aaagattat  cttatatac  12840
tggactaac  ttatagcag  aagccatat  ggtatacta  aaaaagata  tacttctag  12900
ggggaaaaa  aaacacaat  taatccaag  ataaacaat  gtttggcag  accaacact  12960
gtccaattt  ttcccctct  aaattgtcc  aatgtcact  aatcctcca  gaaaatgaa  13020
aaacaaact  cattactgt  acaaaatat  tatccttat  cttggacat  cttttccca  13080
ttttgattc  acaaaattg  tagaacata  taaagaaaa  aatatacgg  aagaattta  13140
gaaactaga  actaaaaac  aaaaatttt  tatagagta  tttttaaaa  acacttgcc  13200
gtgtaacct  tgcgtggta  attactctc  aagcatgca  tgccggtgt  ctgaactaa  13260
tttaatgcc  gatctgcct  atgcatttt  ttggtacca  gaagcaaat  tttatcaaa  13320
attatattt  atatctacc  ctaattgca  caataaagt  aagctcttc  gaacaaact  13380
aaccacaga  gcaactagt  aactttcat  ttttcaaga  tcaagtagt  aaagtatga  13440
aaaagaaaa  agactacac  tcttagcag  cctgagaga  tgcctgaaa  agaaggatg  13500
aatactgaa  caaaccaaa  atcttcaat  agatgtaca  ccatgtgaa  gaaaatata  13560
aacaggtaa  ctgtaataa  atatataag  aatttgtaa  aaaataata  aaataactc  13620
gtaaataaa  atgtttaaa  acattaagt  tcaaaatcc  cttttaaga  atcattttc  13680
aaaatctac  taattctta  aaagaacac  cttatttgg  actttactt  ttcaaacta  13740
cattgccat  cttcttgta  gaatgttaa  gaaaaatca  ttgatattg  tatagaata  13800
agtatattt  accaattca  taaataaaa  ttgaatttt  cgtcctaaa  gctatactt  13860
tatgtacat  ttaaagtat  aatggttat  tttaaagtt  ctgacttgt  tcatttaaa  13920
tgtgatttt  agagaaact  tttcttcct  atctcaaag  gaatttttg  ccaggcaag  13980
tggctcacg  ctcccagaa  tctgggagg  cgaggcagg  ggatcacaa  gtcaagaga  14040
cgagaccat  ctggccaac  tggtgaaac  ctgtctcta  taaaaatac  aaaattagc  14100
gggcgtggt  gtgcacgcc  gtagtccca  ctacttggg  ggctgaggc  ggacaattg  14160
ttgaacctg  gaggcaaag  ttgccatga  ccaagatcg  gccactgca  tccagcctg  14220
gtgacagag  gagactcca  ctcaaaaaa  aaaaaaaaa  aattttccc  gaactaaag  14280
aaaaggact  aagtatatc  atggttcat  ttcactggc  gttcctttc  gaaaattta  14340
aattcatac  ctgaaaaaa  ttttatttt  aagaagttc  aacaactat  catttaatc  14400
aaacactga  gaatataca  gtttcttta  cgtgtatgc  aacgatctc  ttcttattc  14460
aaggagtta  actgggaga  attaccgaa  taaaactct  aaacctaca  caaattatc  14520
atggattag  aagaactaa  taaatacag  aagctgaca  aatacagga  agtaaaaaa  14580
gtgaggtaa  tctcaaaga  tatttgcga  aaataatat  cagctgagc  tgaaggtag  14640
aatgaacac  ttctggaag  aagaagaag  gtgataaaa  gacaagtac  aaaagtaaa  14700
aaaaaaaaa  agtaataag  cagagacta  taactgaag  aatctttga  atgagccac  14760
acatatttc  taaatgata  aaatagtat  ttggaaaga  cactcctgg  ctgtagata  14820
gaccaacaa  agtcaacct  tagaaacat  ttagtttat  agtgaattc  gaggaatat  14880
tacaatgta  ctttaacct  tcacacttt  ttccattaa  ttcttcgca  aaaaaagct  14940
aaaacaatg  aaaactata  aatgtatac  agatctgat  aaactgcct  caattatat  15000
tgataaaca  agatttatc  gtatattaa  agaatgagt  tatgtgtat  tattagtgt  15060
ctgcaacaa  ttaaaatgt  tgaaatagc  agctacaaa  ttatcttca  atacttaga  15120
taaatatta  cctactaaa  agatataga  gttttatca  gttctcaga  gagttacaa  15180
gaaaagcta  aacatgatg  aaataattt  ataacctct  ggcgttcac  tggacattt  15240
aacagtaat  aatataaat  tatgccttc  tctttatat  ctcaaagat  tacagtaaa  15300
atgaaaata  aagaaaatc  cccaactat  gttcagtaa  aaggactcg  atttacaac  15360
acttttctt  gtattacag  gtctcaata  atttattta  atgttttat  aaagtgaat  15420
ataaccatc  agattttat  ctccaatca  aaatagcca  taaagatct  gtaacagac  15480
ctacaaatt  tttatcccc  aactctcct  aagtaactt  agtacttct  ccatcatac  15540
ttagaaacc  aaaataatg  aatatggca  ccactaaag  aaaatacta  actgatata  15600
tctgcaacc  agatgtggc  acaactaag  tgcaagaga  gaagggttg  gaaaaaaaa  15660
tatcgaaac  gtatggact  atctggctt  taaatttct  ggctattaa  atctggatg  15720
tatagtcaa  aacaacaac  acaaaaaga  tccacccca  aactcacat  atgaataca  15780
ccttctact  cctgtcagg  aactttatg  tcaaacctt  gtaaataat  taaagaaag  15840
cagcaaaag  agacaacct  cctaatatg  gtaagcaaa  tctgcagca  taataggaa  15900
agtactcag  acacaggtt  agataggaa  atcacctgt  tatctttgc  tgaagacag  15960
gttacctga  aaaggccca  gtgccatag  acatttaca  taatgtatc  ttgtgataa  16020
gactacaat  aaatgatgg  aaaagtgca  cctattacc  agaagccag  ttcaactac  16080
gtttgtaaa  tatatttag  aaggcaaat  tttatttaa  aaagaaaga  agaaaaaaa  16140
ctaattctc  aattctcct  cctttaagt  tagtcactg  aataactgg  aataagtct  16200
ggatatcct  aaaccctag  acctcatta  tgtggataa  aacataagc  aaaacttct  16260
cctagatcc  aataataca  ttcacttgt  gactggcta  aaaggtagt  caggaaaat  16320
tcctcatag  tgacaggct  aatgtacta  tagcatgcc  ctgccatct  accttataa  16380
atttctatt  gctaagcct  atgactcaa  tctttatct  aacccacta  ctcccgttg  16440
caacacttg  gcacaaagc  caagactgc  cttccacac  tgtatctta  agataattt  16500
ttttgcttc  aatatctga  tttaacagg  agtcaaaaa  gaaagcaaa  aaaaattag  16560
tttttatta  aaaaaaaaa  ggacttaaa  tacagacta  gtatgtggg  aaaaaagca  16620
tagccaagg  attacacta  aaataatct  ctaaccata  attttaaat  caaaagaag  16680
attctaaaa  ttgatccag  aaaaaatat  tttttaaag  atacttaaa  actatttgg  16740
atttcctat  tttaaccat  acaaattct  cattatcca  actgggata  ccttatcgg  16800
gtttttaat  ctaagctag  ttcctcctg  gatcccgtt  gcatttggc  atctcctat  16860
atcagctga  gaatcccca  agttagtga  ctaatttta  tattgctaa  ctaatataa  16920
taagcaggt  aatctgctg  gtaaaaaat  atgcattcc  aagaaaaat  gtctggata  16980
catccaaga  actgcctgt  ttccatacg  cactggcac  cagggaaag  aaaaataca  17040
attcattct  tattgcttt  aatgccttc  aatgataga  tataatcca  ttatgttcc  17100
gccaagcta  gtgattaaa  aaaaaaaaa  ccttaagag  aagatacca  tagactaaa  17160
agagaataa  aggatacga  ctagcaaag  atttagaat  agtaaaaat  tatttattc  17220
tcagattga  attatactg  caaaaaaac  tgttttagg  caggcatgg  ggctgatgc  17280
tacaatccc  gcaattcgg  aggccaagg  aggagaatc  cttgagccc  ggagttcga  17340
accagcctg  gcaatatag  gagaccctg  ctctacttt  aaaaaaaaa  aaaaaaact  17400
gttttaaat  aaattggat  tttcaaata  cacttaaac  aaataaaac  gattttatt  17460
acagtaaga  tgtacaagt  aacataatt  tgacaagaa  tacattcta  ttgatcaga  17520
ctgcatgtt  ttaatgaca  ttatgccaa  aaatacccc  tgagtacat  agtgacttt  17580
gctggataa  tttgataca  aaagaatgg  atcattaat  tgctaacta  gtcaaaaca  17640
tttacttac  ttaaaagtg  aaaaacatt  gactcttta  gctatttta  gcttttatt  17700
aataaaata  gtcaccaaa  tatttgaag  gatacattt  ttaaagcat  cacaatgca  17760
tagtaaccc  tctgtccct  acccaacat  tattgaatg  ctattatat  ccaacacta  17820
gagggatga  taaaaagat  agcacatat  cctggccct  aaaagagtt  acactccat  17880
agcaagata  atctctaaa  catgatttc  attaccagt  gagagtgat  tgacatgat  17940
tagaaaaat  tgaaaatgt  catatctta  taccatatt  tatatactt  tcatatatg  18000
cgtagagaa  tcttgaaga  gagcacaag  gatttatac  ataatttta  tgcaatact  18060
cctctgata  taaaacagt  gaagcaatg  aagtgtcct  caataggaa  tgaataacc  18120
agagattta  acatataat  gaatactaa  aatgaaaaa  aatgaatta  acccattat  18180
gctagatct  aaaaataaa  gtaaacatg  aaattgtag  ctcatatat  ctttgtgag  18240
ccagatatt  aaccatatg  cactagata  aaattacat  tgaccacaa  ctaaataat  18300
ccacatcat  ggtatccac  tacatatta  aatattttt  aaagcattt  agatcatca  18360
agcagttgc  ctggaaggg  acaatggga  aacagtacg  atgtaagac  acagagact  18420
gaagtttat  tgctttatt  attcaagca  cagcagcaa  tttaataaa  tgttaacaa  18480
tgtcaattt  tgggtgaca  gcatacagc  gttattact  ctttttgta  tctatattt  18540
tcttaattt  tcaaaatag  taaataaaa  aagaattaa  atctgatca  atttcacac  18600
tgctaaaat  tcatgctat  gttcttatt  cctagagac  ttcaaattt  acagcatga  18660
actgaaaaa  atttaacaa  ctggtcctt  ctttctttt  cagaccaaa  atgaatact  18720
ccctactac  tagcctatc  acctagtgg  actgtaaca  tcaccactt  ttaagcatt  18780
cccatattt  tctgatgtt  tatctttgt  aacgctctt  tccattagt  caattacct  18840
accctaaaa  atgtctgct  gcatattca  cacatcact  catgtaatt  aaaacttag  18900
tcaaatgtc  cttactatt  ataggattt  cagattcct  tcttatccc  cacataaga  18960
taactattt  tgcaattgg  gtttctata  cactatcat  agaccagga  cttctctct  19020
tggcagtat  actcttgtt  aattcttcg  cacctctca  agtgcctgg  acatagtaa  19080
tgttcaaat  ttaatggaa  tgaatgaac  tctgaaaca  gtgttaagg  acagagtac  19140
gagttatca  ttcatgaat  cattaaaat  gccattaaa  cttctggac  aaaatcaaa  19200
ggtactagc  tctgaatca  aatatcaca  aaatgtaaa  cactatgtc  gtaatacag  19260
gaaattttg  ataaaatac  gcaattcta  tattaatta  attcatatt  aaataggat  19320
aagattaac  ctaaatact  gctttcctc  ttgataatt  caggaattt  cctagaaaa  19380
tttttaaat  cacttctgc  ggtacttgc  gcttctcct  aaatcaatt  tcatcctaa  19440
aaatgattt  ctactcatg  taataatta  cttcttcct  tgatgtctc  cagcactgg  19500
ccataagtg  tttcaaggg  gataatgtc  tttggaagt  gctacttgg  tcaaacgtg  19560
gtggattag  attacaggt  atgtatcca  gcaatccaa  gggctagag  agagaagtt  19620
gggaatctt  acagatctg  gttagaatt  tgactttga  acccacctg  tgttaactt  19680
tttatgcct  aattacctc  ctggtaaaa  tggataaaa  tagctacct  atgtggtag  19740
tatgaggat  aattatata  aacagcata  tacctggta  attaaaaat  ctcaataaa  19800
gataacttg  atcaaacat  ttctattac  agcaaatga  agcaaaatc  tgagatgta  19860
ttgctatgg  ctaaaggtt  gtgtacccc  aaaacccat  tgttgaaat  ctaacctcc  19920
agatgatag  attaggaag  gggatcttt  gggagtgat  aaatcatga  ggcagagcc  19980
taatatatg  gattagtac  tttataaaa  agaacacag  gagcttgtt  gcctttcta  20040
catgtgagg  tacagggag  aggtgtcta  aaactagaa  gcaagccct  accaaacac  20100
aaacctgcc  gtgccttaa  cttggactt  tcagcctcc  gatctgtga  aaacacatg  20160
ctgttgttt  taagttatc  agtttatag  attttggta  agcaaccca  gtggacaaa  20220
acaacaata  gatgatgtt  aatatcttt  gatcacctc  ttagaatgc  acattcaaa  20280
attactgtt  actggaaac  accattctg  gtttaagta  atgccccat  cattaagag  20340
ggaaagaac  ctgaaggcg  gtatatact  tggatgatt  gggaggctc  agtgagtac  20400
taacccttt  tacaaaatc  ctcaaaaat  taaattatt  atgtctggt  ttacaatta  20460
actcacttc  caaggagta  ttgagaaat  agacatcaa  attatagga  gggaactaa  20520
ggtgcggac  accaatctc  ttaatatat  aactcatat  taaacccat  aatttatta  20580
ctctatggt  aacagtaag  gtcaggaaa  ggaagcttt  acataatgc  gaattaact  20640
ctgctattt  aactgtgac  caaatgttt  tcttatata  tactctagt  gattatcaa  20700
atggctacc  attttttca  ctaactgct  caacagcct  aaatcacag  aaagagaaa  20760
aaaaattaa  ctgtcagtg  ctaacaggt  aaaacagac  aggtgatat  agacattga  20820
acagcccaa  tcaaattag  aaactgcag  aagcaaata  taggcttca  tatcctctc  20880
tgataggag  ggaaaaaaa  ctttattga  gctttcttg  gttttgtgg  aatgaaact  20940
atttggcgc  ttacctctt  atctcattt  gtctgatcc  caatagaac  tgtatgaag  21000
agtattgta  cctttctgc  aggaaggaa  acaaagtgc  aaaattaag  taactaaag  21060
aagtcacat  agtaagaaa  agcaggatc  aggttttaa  tgagttcag  gcaactcaa  21120
aatggcgtt  gcctccatc  ccccttaaa  tgctttcag  ctagggggt  gggggggaa  21180
gcctggaga  gtgaatttg  tcctacatc  ttcatgtaa  cctccaaag  atgaaattt  21240
aaacaagat  gttacagca  cagtcaaag  actctaaga  aagtcacag  attataaaa  21300
tagtaaaat  tcaactaag  gactgaaaa  taaacagtc  caattaact  tcaggaaat  21360
aactttcca  ttccctata  tcatttccc  ataactttc  gaaatctat  catagtatt  21420
ctattttct  gagaattga  taatctata  tagtttaca  cctaattat  cagagtaga  21480
aatgtaaaa  ataggccaa  cacacacat  acgcataca  atctacatc  aaaatactc  21540
gacataggg  atagcacag  agctatttt  agaataact  ataaaattc  agtagttta  21600
aacactggc  tatataaca  atggcaggt  atctatccg  cctcatcgt  ttacaatgg  21660
ataaaaagc  acccaaaga  gttctctgt  caaaaagta  agaagcaga  tctggtaca  21720
ggaaattaa  gaagcacag  aaatatact  aactgaggt  tctagataa  gactatatg  21780
tcaaactaa  tatgactta  aaatagctt  gtggcatgc  ctatacaaa  gtgatataa  21840
acctatcac  agaagaaac  gacacatac  atatgctag  ccctcacta  agctatact  21900
ctcaaatct  tgtgtatag  cgacacaag  gttttacag  aaatgcaaa  tatacctat  21960
taggtacat  acacctgtc  cactcaaaa  taactgaaa  agaactcaa  gaattctct  22020
ttgggaaaa  tctacatct  aggccgggc  cggtggctc  cacctgtaa  cccagcact  22080
tgggaggcc  aggtgggcg  atcatgagg  caggagttc  agaccagcc  gaccaacat  22140
gtgaaacgc  atctctact  aaaatacaa  aaaaaatta  ctgggcatg  tggcttgca  22200
ctgtaatcc  agctactca  gaggctgag  caggagaat  gcttgaacc  gggaagagg  22260
agttgcagt  agctgagat  gtgccattg  actccagcc  gggttacag  gcaaaactc  22320
atctcaaaa  gaaaaaaaa  agaaaaaaa  attgtacat  taagtcctc  gttctctgc  22380
tcaccataa  tcatttatg  caaatcatt  tcctcactt  ccacatgaa  aaaacttct  22440
cctcataaa  acaggaatc  ttccccttt  ctaaagttt  tcttactta  actagtgcc  22500
caaataaaa  tgttctact  tcttactac  ttgtgtaaa  tggtaagtt  atcctgtgg  22560
attctagat  caattattt  aaataactt  agaagaaat  ttcccatta  ggtcacata  22620
agaacaaaa  tgtaaaata  accacaaca  cagcagaaa  catcagcag  aacttatag  22680
ggcattaca  ccttatagt  acatcaagg  cataaaagc  atgtcacag  aatatacaa  22740
gacaatgct  ccatctaaa  gccaagata  aatatgaaa  gatgtatgt  tactcaaat  22800
ctaccaaaa  agcttgata  tttaagtca  caaagttta  atgaaaact  tgctatgat  22860
atttttaga  tctgcaatt  agctataat  ctctttttg  gaatattca  tttattaag  22920
gaattagca  aataatttg  ctgattatc  gtatttgtc  aagcatagt  gaaattctt  22980
tggcattct  tctgacagt  ttctctgta  gtacctgta  tagttgcta  cttaaaata  23040
ttgttgtta  attactaag  ataggtgtc  aagtaaaaa  atcctaatt  cttaaagct  23100
tggcttcgc  agtatttaa  tatttctct  tatttcata  attttaaaa  tacaaactt  23160
ctataggag  ttagttatc  atatctcaa  tatccaata  agagttcaa  ttattctaa  23220
tttcctttt  taataaact  aaatgggaa  aactgtagt  aattagcct  taagactta  23280
caaaattac  tcaaatttc  aatgaaatg  aaatgttaa  taaaaaaaa  tacaaaact  23340
atgccctta  catttacgt  tataacata  ttttaatgt  ccaaaatac  agaaaaaaa  23400
taatgtgaa  ataacaaaa  ccttaaaaa  ataaacagt  gctttcttt  ggaaaccat  23460
ggctaaaaa  tgtttgatt  ccaataaaa  tatttcttt  tgtttactc  acaagaaaa  23520
taaaagtca  caaatatcc  actgcttga  aaacagaaa  cttctaaat  gagatcacc  23580
tcctttaat  taccttgga  gtaaagtga  aaccaaaag  taggtaaca  atacagttg  23640
gatgccata  aaactacta  gttttacat  tctcctgta  gtcagactt  gtactagac  23700
acttaaaga  acagtgtca  ttaatcgtc  aaactataa  tagcaaata  acagatatc  23760
ataacttca  ttacaaatg  ggtgtaaag  actcaagta  ctttcccag  gtcactatg  23820
aagtgagtg  ataccaata  tcaaaaatt  agtctaaca  agacctaac  tctctttac  23880
aaatcctac  gtctcaaga  tgactatta  ataaaaatt  ttaaatgtt  tgaactcca  23940
ggggcaata  aaagatctc  tcatttttg  aatacaact  aaaaagcaa  tcttctttg  24000
agtatacta  acattcagg  ctaccctga  aacattttc  aatacagac  tgcattgct  24060
aatgacagg  aaatgttat  agaaatgtg  cattaggta  ttttgtcat  gtgtgaaca  24120
cacagaatg  acttacaca  acctagagc  tacagaaag  cctgggcca  atggtatag  24180
ttttattgc  cctaagctg  aaagctgaa  agcatgtca  tgtaatgaa  actgcaggc  24240
actgtaata  aatggtatt  ctgtatcta  acatagaaa  ggcaaaaat  cagtataat  24300
atcttacag  accactact  tatatgcta  ccactgtta  cccaaacat  gttatatgg  24360
ccatgactg  atgtacgct  tttttcaat  ttaagaact  ctactggtg  atcctagtg  24420
caacttttt  ttttaactg  tatgatgta  ctatcatat  aaaacataa  tgctttgga  24480
tattattca  ccataaaac  taataaagc  ctgatacat  ataaacacg  atgagcctt  24540
aaaacatca  gctgagaca  cagaaacaa  accacgtat  acgtgattc  atttataca  24600
aatatctag  ctaggaaaa  ccatagaga  agaaagtag  ttagcagtt  ccagggact  24660
gaagaaggg  aaaatgggg  gggatagct  atgggcaca  gattttttt  ggggtaatg  24720
aaatattca  aaattagac  ttggtaatg  ctgcacaac  tggtaaata  actaaaaac  24780
gatgagttg  acactttaa  agggtgaaa  gtattttat  tgaattatc  ctcaaaaaa  24840
attgtaaga  ttttaagca  aatatatta  atgtgtctg  attacccat  tatgtgctt  24900
aaatataaa  tctatgtaa  tgccctatt  tatgctcta  cttattgaa  cccattttt  24960
atgatacta  gtaaaagac  ctattttac  agagtacat  tttctggac  ataaaaaaa  25020
ttctaactg  ctagaatta  tataatccc  agagatatc  gaaagaact  cacaaccac  25080
gacttatgt  tggcaaaca  atttgattt  tccaattta  cagtattag  tcactgtcc  25140
catttagaa  agatgcatt  gcacatgct  atgagggat  tttaacatg  aagtaccac  25200
cacaaacac  atctattca  ttaaaagat  aatttataa  atcatcact  taaaaggat  25260
tttgctttt  attaagtag  atttgaacc  tcacaagaa  ataagcaga  aaaattata  25320
ataaacttg  aagaattcg  aggttagga  caaaatgaa  aatacaagg  tgataacaa  25380
tacttacta  tttgttttc  tgcatgtat  tcctttgta  tttcagaca  cccttagct  25440
tgacgatca  gccttcatc  gagatcttg  aacactggc  gaaatgaat  tctttgagt  25500
ctctgcatt  tgagcccag  tgtaaacaa  cagatttag  tgaatgctc  aaaaataac  25560
aaggcaaca  atttcaagt  agattttca  ataattttt  gaaaataac  acgtcagag  25620
taaatattt  tgttacttg  aaaataaga  agaatgtaa  caatccata  cttaaaaca  25680
tactgtata  acattttta  ccttctaat  tacccccgt  tcaaccaac  cacattaca  25740
gccctccaa  gtatgtata  tccttaaca  ttcaaaatt  catatctat  actccagta  25800
atatatttt  aaagacagg  tctcactgt  tcgcccagg  tagagtgca  tggctcaat  25860
atggctcac  gcagcctca  cctcctggg  taaagagat  ctcttacct  agcctcctg  25920
gtagctggg  gtacaggtg  gtgccacca  acctggcta  tttttaaat  ttgttgtag  25980
gctagggtc  cgctatgtt  cccagacta  tctcaaact  ctggcctcg  gcaatcctc  26040
cacctcagc  tcccaaagt  ctgggatta  aggtgtgag  cactgcacc  agcctctct  26100
gagtcttaa  agtgaggaa  aaaatataa  gcttaaagg  ataaattat  gtgtattca  26160
aaaactgaa  attatacaa  cactacaat  ggaagaaac  tttgacaaa  atgtatgta  26220
gtttttata  tataatcca  ttttataaa  aaattatgc  tatttaaat  catacatgt  26280
tatttgtgc  cagaaaagg  actgaaata  ataccaagg  gttcacagt  gttaattct  26340
attagcgca  gagtgagtt  ttattccct  ctgcctatg  atcttctct  attttttta  26400
taaacattg  ttttgtaag  aaaaaaaac  tccaagttc  gtctcaagt  atgacatca  26460
aaatatatg  gagttcagt  acttttcca  gggtggtga  agatataaa  tatattatt  26520
taatctagg  tgcactaca  ccaataaca  attcctaca  aaatgtaaa  tccatgaag  26580
cagcagttt  tctattttg  taaataagg  aactctggt  cccgatatc  tacacttag  26640
tgatactta  taaatattt  ttaaataaa  gaaaaggct  atcaggatt  tgcactata  26700
agcagctct  attttaaat  cgcaaatac  agaaaccat  attttggcc  catatacta  26760
taaattcca  ttaattcag  ggttctaac  ggcccatgg  gagaattca  gggttccag  26820
aaagcagat  ttttaaaag  gcatgttca  tttttatgt  atcctccaa  tgaacttta  26880
cctttcctt  ccatatgaa  aacagcaca  tagcttagc  atacctaag  ctttgtaag  26940
aatagaaat  aaagattat  tcatatatc  ctgttgcag  taccttgaa  tatttttca  27000
tagtagtca  catgctcat  agctatcag  tttttattg  attcattaa  agaggcata  27060
atatttcta  aacaaatgt  gaggaaact  aatccaaag  caacagtgg  aaaagcaaa  27120
aagtctatt  aagaactct  aacaggctc  catatatgt  tggcagtga  gctgaggtt  27180
gggctaaaa  tactagaat  cttgaaagt  tgtttaaaa  ttagttaaa  cctcagatc  27240
cctccccat  actgcacag  ctgaccttg  cctttttcc  acaatggca  aaaaatgta  27300
ttctctggg  agagcaaaa  gtagggttt  tggactggg  tataccaca  atagctgag  27360
accaaagca  aatgctgaa  atatgggga  ttgtgaacg  ttatacagt  aaaacggag  27420
aattcaaag  aacatttct  tcccatttt  cagaatgaa  ggatatcaa  ttccagact  27480
aaaaggctt  tccacttgt  cagcataaa  gacaaaaat  gacacatgg  aatgcaaat  27540
atcaaaaag  ttcagaaac  ggagtttaa  gagattcta  agacttaga  aaacttcat  27600
gaaaggatt  ggatgaaaa  gcatcaaac  tcttaacaa  actaaaaga  agcaacagt  27660
caatgccat  aaattctga  gataaatta  ttctaaccc  gaattctgt  ctcgggatt  27720
agattatga  ttaagtgtg  aagcagaat  agagatgtt  tcagacata  aagttatca  27780
aagatttac  tcccatata  actttatca  gaaggtact  gaatctgtg  tctataaaa  27840
acgagaata  accaaggga  agaaaacat  acatctggg  aacagaaga  ctaacccaa  27900
agcaagaga  agaaaatct  aaggataac  gtcgtaaga  actaaggtg  ccactaatg  27960
catcacact  gtatatgag  agtccagac  agactatcc  aggcaaatc  gctgtaggg  28020
agtaaatgt  attaagtat  cacatatag  catactaat  caactggag  aaagctttg  28080
tcttcatta  tgttaagag  ataaaaact  ggtaaagaa  taaaaagac  tttattaat  28140
ccaatgaaa  caaaatgct  tagagaaaa  agataggta  ataattata  aatgtaaat  28200
ctgaatact  atttaacaa  aattataat  gaattatgt  ggaaggatg  gaggataag  28260
cacagggaa  gaagtataa  tgagctaaa  ccttatctt  gatacaagg  atcagcaat  28320
aacagtcaa  agtgggtaa  ttttttaaa  aatacaaac  aacatgcca  gggaaaatg  28380
tttctcatt  tgtaggaag  ccaactagt  tgattcccg  tctctccac  gattattct  28440
tatttaata  actggatat  ttcagctca  atgtatact  cttcccctt  tgaataaac  28500
gcatacagg  agcaagcaa  ctttatttc  ctatttggg  ccactctgc  ggtcagcct  28560
gtcaatgac  agtcagtta  ccaaactcc  gagtcaggt  aacaatccc  tttagcatt  28620
tttgtaagc  accttctcc  ccttagatt  tctgagtgc  aaagctgac  tcttgctcc  28680
tcatcacta  ttcttcgtc  tacttatca  tttgataac  tcctgagca  tgaatagga  28740
gccccatga  acctcaaca  ttagtacac  agctagaaa  acggagaaa  aaaagaaga  28800
aatctacat  tcaacagaa  gaataagtg  ggtttttgg  gaagtctta  acatcaatg  28860
gcatggaca  gttggtaga  cctcaggtt  agacacgta  atcacagcg  cgcaggctg  28920
gaaaataat  taaactgac  acatggtgt  ttgacattg  aaagtagct  tggtggctt  28980
atctataaa  aaatgactt  tcatacagg  cacgtggat  accacacaa  gatgagaac  29040
atgtggatg  catatgcag  aattaccag  atgtgaggt  aagtcagat  tggggaaca  29100
tgcctcaca  gagaagcta  tatgattta  tactactga  taaaaccat  atttaatct  29160
actgcagaa  ctgatattc  gttttagac  tcactggat  taaccggca  gaccagacc  29220
aaatcagtg  ctatctgca  tactcacca  tacgccatc  acaaatgtc  taagttcca  29280
actatccaa  cactgtaaa  tcaatcatt  taactgata  atttacaat  tggctgaca  29340
tctttaaat  tctcaatgt  gtattcatc  atgacccac  gaaaaacat  cagagggca  29400
caaccaaat  ttacaaaat  atcaccatt  ggatgcctt  aatctagca  aattagtac  29460
ctatctaaa  accatagaa  tagaataca  ttctttttt  ttgttgttt  gttttttga  29520
acggagttt  gctctttcg  ccaggctgg  gtgcagtgg  gtgatctcg  ctcactgca  29580
actccacct  ctggtttca  gcgattctc  tgcctcagc  tcccgagta  ctgggacta  29640
aggcacccg  catgactcc  agctaattt  tgtattttt  gtagacacg  agtttcact  29700
tgttggcca  gctggtctc  aactcctga  ctcatgatc  gcccgcctc  gcctcccaa  29760
gtgctggga  tacaggcgt  agccactgc  cctggacga  tataattct  ctaaataaa  29820
aattatctg  ccaggaaga  agtgctaga  acactggag  tctactctg  caaaaggga  29880
aaatcctgt  aagtgccct  gcatccagc  gagacacca  aaagatggt  ccttgggag  29940
aagaactat  ccctagaat  aggcctatt  tagatgatc  aagttagag  gatttggga  30000
acaccttgg  ctttccaca  aataaagca  aaaactgaa  acaaacaag  caaggatga  30060
cattcagta  ctgtaatgc  tgctttaaa  gaaaagatt  ctggttttc  gtctggcat  30120
taaggagtt  agaagttgc  aatctgttc  aaaaaataa  aagctgatc  cactgaaaa  30180
ttaacaatt  tttttagat  catcagaga  atgaagaca  agaccaaac  actgccaca  30240
aactgcaga  acagacaga  gcagagaag  acaactcac  agaagagaa  ctactacca  30300
aaacctcag  gggaaccag  gctagagta  gaaaacctg  actctgcat  tgacaaaat  30360
ctggaggca  agcgtggat  agtctgata  ttaaaaatt  cagggggac  aggttataa  30420
acaacactc  tgcttttgt  agttttatc  acaggagct  taccaggtc  tcacggaga  30480
tactggaga  aaatcacct  atgcataca  caatgagag  agaaaagta  ccattttga  30540
atatgccag  gcattctat  atttttaac  aggcctgtc  tcaggagga  ctgttttac  30600
agagcctaa  ctgtgggag  tttgtcaga  cctaacctt  ctaggggaa  ggaaatatt  30660
aactccagc  agttctagc  ttccatgta  ggaaaggga  ataccaaac  ccagccctc  30720
ctagccatc  cagcccacc  aagggtaag  ggaaaaaaa  aagcactgg  aaaggtagc  30780
cagtggcac  gacttgcca  aatattaaa  cctaatcct  aaactatag  tcattcctc  30840
tctccccac  cctaaccac  acattacta  aggcccatt  atgaaagtt  catttccca  30900
tataggttg  gtatccctt  tccaaaatg  ttgggacca  aagcgtttt  attgttgga  30960
ttttttcag  tttttgaat  tttgcatta  atttatcag  tgagcatgc  taatctgaa  31020
atccaaaat  caaaatgtt  taatgcata  ttcctttga  tatcctgtc  gcactcaaa  31080
agtttccaa  cttggaaca  actggattt  ggaactttg  attagggac  ttcaacctg  31140
gcatcgtgt  cacctttca  tgaaaaatt  aaaggcata  caacaagga  aagacaatt  31200
caggagact  aaaaaagca  cagaaccac  gtcagatac  gcaggaatg  tggaattac  31260
aggccggaa  ttttttaaa  ctacaatta  tatgttaag  gctttaatg  gaaaagtag  31320
caacacgca  gcaccaata  gcactataa  aagatacat  agtagatgg  acatggtta  31380
ggaaaaagt  tgagtttga  aatataata  aaagttcca  aactgaaaa  caggagaaa  31440
aagactgaa  aaaaatgaa  agaatatct  agaaccaca  aacaactac  aaaggtata  31500
cataagtga  aagtgaata  caagaaaag  gagagagac  ggaacagag  aacatttga  31560
gcactcctg  ctaataatt  acccaaatt  agatcagat  ccaaactac  gacccaaga  31620
gttcagaga  taccatgaa  gaaaactgc  aacaaacaa  caaagaaaa  actacacct  31680
ggcatatca  tttcaaact  caaaaaatc  aaggttaaa  aaaaaaaga  aaaaaaa  31737



<210> 5435
<211> 446
<212> DNA
<213> Rattus norvegicus
<308> AA891521
<400> 5435

agcgttaag  acactaagg  tcaatgatt  aataaatgt  tacacaata  tccatacaa  60
agtagcaaa  cacacattc  tttaatcaa  acacaaaac  ctatttttc  aaacatttt  120
agccattac  acaaggttt  caaatctga  aaacgagaa  ggaagaaaa  ggaagaaaa  180
aattatagg  caatataat  tttgataat  cttgatcat  tttgaaact  attaggtga  240
taaatcctt  ataaggtac  tgcaaattg  actcagaaa  atatgttaa  acatcatca  300
aattgtcag  ttcatctca  ggatgctag  atagatcta  atttgtaaa  caatattta  360
ttcagtatt  aatagaatt  agacaaaaa  atcatcatc  agatcaatg  aaaggaaac  420
tatgaaatg  aattataac  tttggg  446



<210> 5436
<211> 1595
<212> DNA
<213> Homo sapiens
<308> AY027526
<400> 5436

gggaagtgg  aggctaccc  catctttca  taatggcag  ctaggacaa  cattaccca  60
gcctgcaag  ttgttaagg  ctaggaacc  aagcaagaa  tcaccatgc  aatcaaacc  120
gttgggtgg  tatgtgggc  ggtgttgaa  aacttttct  gaagaatcg  ggggatcca  180
aaagcaatc  tggaccttg  agatgagtt  aaagatgaa  ttcccacca  cctaagatt  240
tcacagtct  atcagaaaa  agaacctgc  cagaaaaca  ccaaaatca  gatggctat  300
gctttagct  agattaatc  agcaacatt  attcgtgga  taaacagca  atccagatc  360
tccaaatca  tggccaaac  tctgcatcc  cagcttaca  gcagacttt  agagctaag  420
gacatatct  gtcgtctgc  gagggaagt  aatgcgccg  ggcaacccc  atataacat  480
caggtcaga  agggttctt  gtttgaaat  atctccttt  cagcaaaga  tgctttaac  540
agcataata  atgcttcat  tgcagcact  atttatttg  cagtctgtg  taatgctgt  600
ctgaagaag  taaagaaca  cttccagga  gaagaatcc  taaggcaaa  cagagagga  660
agtgaaaat  gtagaaaag  cttttctga  cctgtgctt  cggagccta  gtttgctga  720
ggtgaaatc  aagcaaaac  ttataggtc  ttgccggag  agccagaca  ttcagatta  780
cccaagctt  ttgctaata  gcagagtaa  aacatccaa  ttttacatt  tgtgtttga  840
caatcagct  aaatgaatg  gcaaatctg  atacaggca  tcaaagaac  ttggctcac  900
gaataggag  ctttacatc  ctcatggct  ggcagcagc  gtgtctggc  tccttactt  960
aagatctgc  ttgatcaca  atcacttaa  agtggttaa  tttcttatt  tcaagttca  1020
caggggcaa  ctatacacg  tcgtccatc  aaatcctgg  gaagagaat  actcattta  1080
tattctgac  tgtcaaatg  tcttgatag  ctctgaaga  tctgctgca  aagaaccag  1140
ttaaaaaaa  agtaggtct  aggggttgg  gtgacaaga  tctgcatgt  taagaagct  1200
ccatgtgac  ccaaagttg  tggtctatg  acaacagtt  gaggagcaa  gtcttcaag  1260
tctcattat  gactgaaac  ggagaaaat  ctatggaac  attatcagc  cacacatat  1320
aaaactggt  actgagatg  cagctgagc  gaaatgccc  aaatgcaaa  gaactagac  1380
tgccaacag  ttggggaag  gaattccat  ctgaaagaa  agcaaatac  aaagcctga  1440
ggaaagaaa  gtcttggtg  atgtgttcc  gaagactgg  acataatat  caagattgg  1500
aaacaggca  gagccaggt  gtgcagtgc  gtgtatgga  tttacttct  agagcaaag  1560
aaagcccct  aagaagtaa  aaaaaaaaa  aaaaa  1595



<210> 5437
<211> 255
<212> PRT
<213> Homo sapiens
<308> AY027526
<400> 5437

Met Pro Ile Lys Pro Val Gly Trp Ile Cys Gly Gln Val Leu Lys Asn 
  1               5                  10                  15
Phe Ser Gly Arg Ile Glu Gly Ile Gln Lys Ala Ile Met Asp Leu Val 
             20                  25                  30
Asp Glu Phe Lys Asp Glu Phe Pro Thr Ile Leu Arg Leu Ser Gln Ser 
         35                  40                  45
Asn Gln Lys Arg Glu Pro Ala Gln Lys Thr Ser Lys Ile Arg Met Ala 
     50                  55                  60
Ile Ala Leu Ala Lys Ile Asn Arg Ala Thr Leu Ile Arg Gly Leu Asn 
 65                  70                  75                  80
Ser Ile Ser Arg Ser Ser Lys Ser Val Ala Lys Leu Leu His Pro Gln 
                 85                  90                  95
Leu Thr Cys Arg Leu Leu Glu Leu Arg Asp Ile Ser Gly Arg Leu Leu 
             100                105                110
Arg Glu Val Asn Ala Pro Arg Gln Pro Leu Tyr Asn Ile Gln Val Arg 
         115                120                125
Lys Gly Ser Leu Phe Glu Ile Ile Ser Phe Pro Ala Lys Thr Ala Leu 
     130                135                140
Thr Ser Ile Ile Tyr Ala Ser Tyr Ala Ala Leu Ile Tyr Leu Ala Val 
 145                150                155                160
Cys Val Asn Ala Val Leu Lys Lys Val Lys Asn Ile Phe Gln Glu Glu 
                 165                170                175
Glu Ser Ile Arg Gln Asn Arg Glu Glu Ser Glu Asn Cys Arg Lys Ala 
             180                185                190
Phe Ser Glu Pro Val Leu Ser Glu Pro Met Phe Ala Glu Gly Glu Ile 
         195                200                205
Lys Ala Lys Pro Tyr Arg Ser Leu Pro Glu Lys Pro Asp Ile Ser Asp 
     210                215                220
Tyr Pro Lys Leu Leu Ala Asn Lys Gln Ser Asn Asn Ile Gln Val Leu 
 225                230                235                240
His Ser Val Phe Asp Gln Ser Ala Glu Met Asn Glu Gln Ile Ter 
                 245                250                255



<210> 5438
<211> 446
<212> DNA
<213> Rattus norvegicus
<308> AA891521
<400> 5438

agcgttaag  acactaagg  tcaatgatt  aataaatgt  tacacaata  tccatacaa  60
agtagcaaa  cacacattc  tttaatcaa  acacaaaac  ctatttttc  aaacatttt  120
agccattac  acaaggttt  caaatctga  aaacgagaa  ggaagaaaa  ggaagaaaa  180
aattatagg  caatataat  tttgataat  cttgatcat  tttgaaact  attaggtga  240
taaatcctt  ataaggtac  tgcaaattg  actcagaaa  atatgttaa  acatcatca  300
aattgtcag  ttcatctca  ggatgctag  atagatcta  atttgtaaa  caatattta  360
ttcagtatt  aatagaatt  agacaaaaa  atcatcatc  agatcaatg  aaaggaaac  420
tatgaaatg  aattataac  tttggg  446



<210> 5439
<211> 1595
<212> DNA
<213> Homo sapiens
<308> AY027526
<400> 5439

gggaagtgg  aggctaccc  catctttca  taatggcag  ctaggacaa  cattaccca  60
gcctgcaag  ttgttaagg  ctaggaacc  aagcaagaa  tcaccatgc  aatcaaacc  120
gttgggtgg  tatgtgggc  ggtgttgaa  aacttttct  gaagaatcg  ggggatcca  180
aaagcaatc  tggaccttg  agatgagtt  aaagatgaa  ttcccacca  cctaagatt  240
tcacagtct  atcagaaaa  agaacctgc  cagaaaaca  ccaaaatca  gatggctat  300
gctttagct  agattaatc  agcaacatt  attcgtgga  taaacagca  atccagatc  360
tccaaatca  tggccaaac  tctgcatcc  cagcttaca  gcagacttt  agagctaag  420
gacatatct  gtcgtctgc  gagggaagt  aatgcgccg  ggcaacccc  atataacat  480
caggtcaga  agggttctt  gtttgaaat  atctccttt  cagcaaaga  tgctttaac  540
agcataata  atgcttcat  tgcagcact  atttatttg  cagtctgtg  taatgctgt  600
ctgaagaag  taaagaaca  cttccagga  gaagaatcc  taaggcaaa  cagagagga  660
agtgaaaat  gtagaaaag  cttttctga  cctgtgctt  cggagccta  gtttgctga  720
ggtgaaatc  aagcaaaac  ttataggtc  ttgccggag  agccagaca  ttcagatta  780
cccaagctt  ttgctaata  gcagagtaa  aacatccaa  ttttacatt  tgtgtttga  840
caatcagct  aaatgaatg  gcaaatctg  atacaggca  tcaaagaac  ttggctcac  900
gaataggag  ctttacatc  ctcatggct  ggcagcagc  gtgtctggc  tccttactt  960
aagatctgc  ttgatcaca  atcacttaa  agtggttaa  tttcttatt  tcaagttca  1020
caggggcaa  ctatacacg  tcgtccatc  aaatcctgg  gaagagaat  actcattta  1080
tattctgac  tgtcaaatg  tcttgatag  ctctgaaga  tctgctgca  aagaaccag  1140
ttaaaaaaa  agtaggtct  aggggttgg  gtgacaaga  tctgcatgt  taagaagct  1200
ccatgtgac  ccaaagttg  tggtctatg  acaacagtt  gaggagcaa  gtcttcaag  1260
tctcattat  gactgaaac  ggagaaaat  ctatggaac  attatcagc  cacacatat  1320
aaaactggt  actgagatg  cagctgagc  gaaatgccc  aaatgcaaa  gaactagac  1380
tgccaacag  ttggggaag  gaattccat  ctgaaagaa  agcaaatac  aaagcctga  1440
ggaaagaaa  gtcttggtg  atgtgttcc  gaagactgg  acataatat  caagattgg  1500
aaacaggca  gagccaggt  gtgcagtgc  gtgtatgga  tttacttct  agagcaaag  1560
aaagcccct  aagaagtaa  aaaaaaaaa  aaaaa  1595



<210> 5440
<211> 255
<212> PRT
<213> Homo sapiens
<308> AY027526
<400> 5440

Met Pro Ile Lys Pro Val Gly Trp Ile Cys Gly Gln Val Leu Lys Asn 
  1               5                  10                  15
Phe Ser Gly Arg Ile Glu Gly Ile Gln Lys Ala Ile Met Asp Leu Val 
             20                  25                  30
Asp Glu Phe Lys Asp Glu Phe Pro Thr Ile Leu Arg Leu Ser Gln Ser 
         35                  40                  45
Asn Gln Lys Arg Glu Pro Ala Gln Lys Thr Ser Lys Ile Arg Met Ala 
     50                  55                  60
Ile Ala Leu Ala Lys Ile Asn Arg Ala Thr Leu Ile Arg Gly Leu Asn 
 65                  70                  75                  80
Ser Ile Ser Arg Ser Ser Lys Ser Val Ala Lys Leu Leu His Pro Gln 
                 85                  90                  95
Leu Thr Cys Arg Leu Leu Glu Leu Arg Asp Ile Ser Gly Arg Leu Leu 
             100                105                110
Arg Glu Val Asn Ala Pro Arg Gln Pro Leu Tyr Asn Ile Gln Val Arg 
         115                120                125
Lys Gly Ser Leu Phe Glu Ile Ile Ser Phe Pro Ala Lys Thr Ala Leu 
     130                135                140
Thr Ser Ile Ile Tyr Ala Ser Tyr Ala Ala Leu Ile Tyr Leu Ala Val 
 145                150                155                160
Cys Val Asn Ala Val Leu Lys Lys Val Lys Asn Ile Phe Gln Glu Glu 
                 165                170                175
Glu Ser Ile Arg Gln Asn Arg Glu Glu Ser Glu Asn Cys Arg Lys Ala 
             180                185                190
Phe Ser Glu Pro Val Leu Ser Glu Pro Met Phe Ala Glu Gly Glu Ile 
         195                200                205
Lys Ala Lys Pro Tyr Arg Ser Leu Pro Glu Lys Pro Asp Ile Ser Asp 
     210                215                220
Tyr Pro Lys Leu Leu Ala Asn Lys Gln Ser Asn Asn Ile Gln Val Leu 
 225                230                235                240
His Ser Val Phe Asp Gln Ser Ala Glu Met Asn Glu Gln Ile Ter 
                 245                250                255



<210> 5441
<211> 549
<212> DNA
<213> Rattus norvegicus
<308> AA891537
<400> 5441

ggcaagtaa  attttaatt  ttctagcta  aaacaagca  acattacag  tataacacg  60
aaatatatt  gacgaagaa  gctattata  atttctcaa  aactaaaat  acataccag  120
agctactag  actatccca  acatggttc  aactcttca  tgtcccctc  ggctcaaca  180
gtgggtatt  ggggatggc  gaacttggt  tgggacacg  gactgtcag  ctggcatga  240
atgagcctt  ttcctgaat  gacatggac  gcatgcact  attcagtag  tcctcttcc  300
ttgtctcat  gttcatgca  ggctgataa  ccttagaag  aactggtag  aagaacagt  360
tgcctggtc  tctaaaaat  ttcagggac  tgcatcttg  tttagatgc  tatccaatt  420
ttaaccctt  tttgtgtct  aggggtctc  aaagggcat  tatgatcat  tcaggtgct  480
ctgctgcaa  gcccagaga  tcttctctc  ccagatggt  tctccatgt  gtgcagggg  540
aatgctgtt  549



<210> 5442
<211> 251
<212> PRT
<213> Rattus norvegicus
<308> BAB23885
<400> 5442

Met Pro Ser Arg Trp Pro Gly Val Ala Gly Pro Pro Ala Leu Ala Arg 
  1               5                  10                  15
Thr Glu Gly Gly Glu Gly Ser Ala Gly His Ser Tyr Pro Gln Asn Ser 
             20                  25                  30
Lys Gly Thr Gly Glu Gln His Lys Ala Asp Arg Ile Lys Glu Gly His 
         35                  40                  45
Arg Val Tyr Ala His Ile Ala Lys Leu Gln Glu Leu Trp Lys Thr Thr 
     50                  55                  60
Gln Ile Gln Thr Ile His Ile Pro Lys Ser Met Thr Asp Ala Ser Phe 
 65                  70                  75                  80
Leu Lys His Pro Glu Leu Thr Leu Gly Gln Lys Arg Tyr Leu Cys Ser 
                 85                  90                  95
Val Ala Lys Ile Cys Asn Ser Ser Tyr Leu Arg Thr Leu Met Lys Arg 
             100                105                110
Gln Tyr Met His Ile Phe His His Gly Ser Gln Lys Thr Gly Val Leu 
         115                120                125
Thr His His Arg Gly His Met Ser Ser Arg Tyr Ser Gln Lys Gln His 
     130                135                140
Ser Pro Cys Thr Ala Trp Arg His His Leu Glu Arg Glu Asp Ser Leu 
 145                150                155                160
Ser Ile Ala Ala Gly Ala Pro Glu Met Ile Ile His Ser Leu Trp Arg 
                 165                170                175
Pro Leu Arg His Lys Glu Gly Leu Lys Ile Gly Tyr Ala Ser Lys Thr 
             180                185                190
Arg Cys Lys Ser Leu Lys Ile Phe Arg Arg Pro Gly Arg Leu Phe Leu 
         195                200                205
Leu Pro Val Pro Ser Asn Asp Ser Gln Ser Cys Pro Ser Glu Glu Thr 
     210                215                220
Gln Glu Glu Asp Leu Leu Asn Lys Cys Met Gln Ser Met Ser Ile Gln 
 225                230                235                240
Glu Gln Gly Pro Ala His Ala Ser Leu Thr Val 
                 245                250



<210> 5443
<211> 1506
<212> DNA
<213> Homo sapiens
<308> U79274
<400> 5443

aagcttgga  acctgagta  taacggaca  cagataaag  tccgcatcc  tgcgccacg  60
gcttcggtc  gtggtttgc  tgcagacgt  tgacctgta  ggtgaccct  gcgatttgc  120
aatgtgctg  ggatctgga  tactgaagt  gaaggcacc  cttgttttg  ggagcatgt  180
tatttccct  ctgtgacgc  ctgcttcca  agagaggtg  aaacgtgca  acgctcagc  240
accgcagcg  tcctgcccc  cccccaccg  aactccggg  tcgcggatc  gcccgcccc  300
ctctcccga  gctgttcgg  cagtgtccg  acggcttcg  aggggcgag  agccagcat  360
cgagccgcc  ctccggaat  ccagcagcc  gacgcacgc  tgctgtcgg  ggagggatg  420
tgggacagc  gctcccgca  acggctcgc  gtctcggcg  cgcggagat  cccggccag  480
gtccggggt  cgactggac  gagcgtagc  cttctgcag  gccgcccgc  gtggccggg  540
ccgagggtg  cggcggcgg  tcagctgga  actcttgtt  ccagaattc  aaaggttct  600
atagaatca  agatggata  aaagtgaac  cacacatag  taagctgca  gagttatgg  660
aaactcccc  aaatcaaac  atccacctc  ctaaatcaa  gatggaggc  tcctttttc  720
agcatccag  cctcaccac  ggccagaag  gttacctgt  cagcattgc  aaaatctat  780
atgcaaact  tctgaagat  ttaatgaag  ggcagtaca  gcacgtact  cagcacagc  840
cacaaaagc  aggtgtcct  actcatcac  gaagccgcc  tagctcccg  tactcacag  900
aacagcatt  cccttgcac  acatggcga  atcaactgg  gagagagga  tcggggtct  960
ctgatatcg  agctgcatc  gcacctgaa  tgctcatac  gcattccct  tggtggcca  1020
tgagaaaca  agaagggat  aaaactgga  atgcatcta  aacaagatg  aagtcactg  1080
agattttta  aagaccaag  aaactgttc  tgcaaacag  ttcttcaga  gattctgaa  1140
cacacatga  tgaagaaaa  aaggaagaa  atttactaa  taattttat  caatcaatg  1200
caattgaag  acagggaga  catctgatg  taacttgac  gtcttgtct  gtgtattga  1260
ttcgtgcca  aggtgaggg  aaggggttg  gagttgtgt  ctgtatgtt  aggatggta  1320
tgttattta  taaatcatt  agtaatttt  gtttgttca  aaacttaaa  caatgtaat  1380
ggtctgatg  agttccatg  accaatgat  gttatgtaa  aaaatttac  tgtaacata  1440
acttgtact  ctagctaga  acaattaaa  cttttcttg  attcaaaaa  aaaaaaaaa  1500
aaaaaa  1506



<210> 5444
<211> 274
<212> PRT
<213> Homo sapiens
<308> U79274
<400> 5444

Met Leu Gly Gln Leu Leu Pro His Thr Ala Arg Gly Leu Gly Ala Ala 
  1               5                  10                  15
Glu Met Pro Gly Gln Gly Pro Gly Ser Asp Trp Thr Glu Arg Ser Ser 
             20                  25                  30
Ser Ala Glu Pro Pro Ala Val Ala Gly Thr Glu Gly Gly Gly Gly Gly 
         35                  40                  45
Ser Ala Gly Tyr Ser Cys Tyr Gln Asn Ser Lys Gly Ser Asp Arg Ile 
     50                  55                  60
Lys Asp Gly Tyr Lys Val Asn Ser His Ile Ala Lys Leu Gln Glu Leu 
 65                  70                  75                  80
Trp Lys Thr Pro Gln Asn Gln Thr Ile His Leu Ser Lys Ser Met Met 
                 85                  90                  95
Glu Ala Ser Phe Phe Lys His Pro Asp Leu Thr Thr Gly Gln Lys Arg 
             100                105                110
Tyr Leu Cys Ser Ile Ala Lys Ile Tyr Asn Ala Asn Tyr Leu Lys Met 
         115                120                125
Leu Met Lys Arg Gln Tyr Met His Val Leu Gln His Ser Ser Gln Lys 
     130                135                140
Pro Gly Val Leu Thr His His Arg Ser Arg Leu Ser Ser Arg Tyr Ser 
 145                150                155                160
Gln Lys Gln His Tyr Pro Cys Thr Thr Trp Arg His Gln Leu Glu Arg 
                 165                170                175
Glu Asp Ser Gly Ser Ser Asp Ile Ala Ala Ala Ser Ala Pro Glu Met 
             180                185                190
Leu Ile Gln His Ser Leu Trp Trp Pro Val Arg Asn Lys Glu Gly Ile 
         195                200                205
Lys Thr Gly Tyr Ala Ser Lys Thr Arg Cys Lys Ser Leu Lys Ile Phe 
     210                215                220
Arg Arg Pro Arg Lys Leu Phe Met Gln Thr Val Ser Ser Asp Asp Ser 
 225                230                235                240
Glu Ser His Met Ser Glu Glu Lys Lys Glu Glu Asp Leu Leu Asn Asn 
                 245                250                255
Phe Met Gln Ser Met Ser Ile Glu Glu Gln Gly Glu His Leu Met Leu 
             260                265                270
Thr Ter 
         275



<210> 5445
<211> 598
<212> DNA
<213> Rattus norvegicus
<308> AA891542
<400> 5445

cataatact  tcattacaa  aaaatacaa  aaactacta  aaaaacatt  aggggcttg  60
caaagtgag  aaacctaaa  accccaccc  aggaccaac  gaagcagtt  tctcccagc  120
ccttcacta  tcgactttt  tacaactgt  ggagtgggg  ggggtgagg  tcacacagg  180
agagaggct  gaaatttcc  acacagcct  caagaaaag  aagaaataa  tagcttcac  240
tatcgcaaa  gtggggctt  gaagtttgg  gtggctagg  cctgagttc  gagatatgg  300
aaggaacct  tgatcctga  tctcttggt  gggaacagc  gccacctga  cccaaagcc  360
ttttccttc  tggtgatgg  tgggagatg  gtcctgccc  acctcttag  tgtggtgga  420
ggttcaagc  ctcctttct  ctctccacc  ctgaacact  cccagagca  ctgaggggg  480
cagatcctc  aactctgtg  ggtgtaggc  aggcagctg  tgggaaggc  cctaagggt  540
ggctcaact  cctgcccca  atgaaaagt  tctcgtgct  aaatgacag  cttgttca  598



<210> 5446
<211> 348
<212> PRT
<213> Rattus norvegicus
<308> AAC64141
<400> 5446

Met Gly Lys Asp Tyr Tyr Lys Ile Leu Gly Ile Pro Ser Gly Ala Asn 
  1               5                  10                  15
Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Met Ala Leu Lys Tyr His 
             20                  25                  30
Pro Asp Lys Asn Lys Glu Pro Asn Ala Glu Glu Lys Phe Lys Glu Ile 
         35                  40                  45
Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Lys Lys Arg Ser Leu Tyr 
     50                  55                  60
Asp Gln Tyr Gly Glu Glu Gly Leu Lys Thr Gly Gly Gly Ser Ser Gly 
 65                  70                  75                  80
Gly Ser Gly Gly Ser Phe His Tyr Thr Phe His Gly Asp Pro His Ala 
                 85                  90                  95
Thr Phe Ala Ser Phe Phe Gly Gly Ser Asn Pro Phe Asp Ile Phe Phe 
             100                105                110
Ala Ser Ser Arg Ser Thr Arg Pro Phe Ser Gly Phe Asp Pro Asp Asp 
         115                120                125
Met Asp Val Asp Glu Asp Glu Asp Pro Phe Gly Ala Phe Gly Arg Phe 
     130                135                140
Gly Phe Asn Gly Leu Ser Arg Gly Pro Arg Arg Ala Pro Glu Pro Leu 
 145                150                155                160
Tyr Pro Arg Arg Lys Val Gln Asp Pro Pro Val Val His Glu Leu Arg 
                 165                170                175
Val Ser Leu Glu Glu Ile Tyr His Gly Ser Thr Lys Arg Met Lys Ile 
             180                185                190
Thr Arg Arg Arg Leu Asn Pro Asp Gly Arg Thr Val Arg Thr Glu Asp 
         195                200                205
Lys Ile Leu His Ile Val Ile Lys Arg Gly Trp Lys Glu Gly Thr Lys 
     210                215                220
Ile Thr Phe Pro Lys Glu Gly Asp Ala Thr Pro Asp Asn Ile Pro Ala 
 225                230                235                240
Asp Ile Val Phe Val Leu Lys Asp Lys Pro His Ala His Phe Arg Arg 
                 245                250                255
Asp Gly Thr Asn Val Leu Tyr Ser Ala Leu Ile Ser Leu Lys Glu Ala 
             260                265                270
Leu Cys Gly Cys Thr Val Asn Ile Pro Thr Ile Asp Gly Arg Val Ile 
         275                280                285
Pro Leu Pro Cys Asn Asp Val Ile Lys Pro Gly Thr Val Lys Arg Leu 
     290                295                300
Arg Gly Glu Gly Leu Pro Phe Pro Lys Val Pro Thr Gln Arg Gly Asp 
 305                310                315                320
Leu Ile Val Glu Phe Lys Val Arg Phe Pro Asp Arg Leu Thr Pro Gln 
                 325                330                335
Thr Arg Gln Ile Leu Lys Gln His Leu Pro Cys Ser 
             340                345



<210> 5448
<211> 348
<212> PRT
<213> Homo sapiens
<308> O75953
<400> 5448

Met Gly Lys Asp Tyr Tyr Lys Ile Leu Gly Ile Pro Ser Gly Ala Asn 
  1               5                  10                  15
Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Met Ala Leu Lys Tyr His 
             20                  25                  30
Pro Asp Lys Asn Lys Glu Pro Asn Ala Glu Glu Lys Phe Lys Glu Ile 
         35                  40                  45
Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Lys Lys Arg Gly Leu Tyr 
     50                  55                  60
Asp Gln Tyr Gly Glu Glu Gly Leu Lys Thr Gly Gly Gly Thr Ser Gly 
 65                  70                  75                  80
Gly Ser Ser Gly Ser Phe His Tyr Thr Phe His Gly Asp Pro His Ala 
                 85                  90                  95
Thr Phe Ala Ser Phe Phe Gly Gly Ser Asn Pro Phe Asp Ile Phe Phe 
             100                105                110
Ala Ser Ser Arg Ser Thr Arg Pro Phe Ser Gly Phe Asp Pro Asp Asp 
         115                120                125
Met Asp Val Asp Glu Asp Glu Asp Pro Phe Gly Ala Phe Gly Arg Phe 
     130                135                140
Gly Phe Asn Gly Leu Ser Arg Gly Pro Arg Arg Ala Pro Glu Pro Leu 
 145                150                155                160
Tyr Pro Arg Arg Lys Val Gln Asp Pro Pro Val Val His Glu Leu Arg 
                 165                170                175
Val Ser Leu Glu Glu Ile Tyr His Gly Ser Thr Lys Arg Met Lys Ile 
             180                185                190
Thr Arg Arg Arg Leu Asn Pro Asp Gly Arg Thr Val Arg Thr Glu Asp 
         195                200                205
Lys Ile Leu His Ile Val Ile Lys Arg Gly Trp Lys Glu Gly Thr Lys 
     210                215                220
Ile Thr Phe Pro Lys Glu Gly Asp Ala Thr Pro Asp Asn Ile Pro Ala 
 225                230                235                240
Asp Ile Val Phe Val Leu Lys Asp Lys Pro His Ala His Phe Arg Arg 
                 245                250                255
Asp Gly Thr Asn Val Leu Tyr Ser Ala Leu Ile Ser Leu Lys Glu Ala 
             260                265                270
Leu Cys Gly Cys Thr Val Asn Ile Pro Thr Ile Asp Gly Arg Val Ile 
         275                280                285
Pro Leu Pro Cys Asn Asp Val Ile Lys Pro Gly Thr Val Lys Arg Leu 
     290                295                300
Arg Gly Glu Gly Leu Pro Phe Pro Lys Val Pro Thr Gln Arg Gly Asp 
 305                310                315                320
Leu Ile Val Glu Phe Lys Val Arg Phe Pro Asp Arg Leu Thr Pro Gln 
                 325                330                335
Thr Arg Gln Ile Leu Lys Gln His Leu Pro Cys Ser 
             340                345



<210> 5449
<211> 614
<212> DNA
<213> Rattus norvegicus
<308> AA891553
<400> 5449

aattttatt  cttctgcta  agaacagga  ctggacaca  gctgcccag  cacagctag  60
tgctaacac  cgcaggcac  aggccaact  acttaagtt  cttcctctt  ttcttcttc  120
tcctcttcc  cctcatcct  ttcgtcctc  tcagagctg  aggtgccat  aggcaagct  180
tagactcgg  tgacctgct  gttggggtc  ttgaggatg  ggtatttgc  ctcctccag  240
ttcatgcag  tatcaatga  acagcgcag  atgccccag  cattctcca  actcaggtt  300
atttggctg  caaactcat  gggcttaaa  tgctgggtg  ccaggatga  gtggcgcga  360
gagtccttt  catggtacc  ggacacata  ccgagcttc  agtactcag  gccagccag  420
aaagcacag  acgtccatc  cgccaactt  tagctgttg  tcttcaact  agtggcgat  480
acagcccca  gctgagagt  cagcttctg  cgccagtca  cgccattac  atgcctgga  540
tcccattca  tgagtgtct  gatgttgat  aaggacact  ccccgttgg  cccagtcat  600
acgccatca  gttc  614



<210> 5450
<211> 547
<212> PRT
<213> Rattus norvegicus
<308> NP_061219
<400> 5450

Met Ala Lys Phe Met Thr Pro Val Ile Gln Asp Asn Pro Ser Gly Trp 
  1               5                  10                  15
Gly Pro Cys Ala Val Pro Glu Gln Phe Arg Asp Met Pro Tyr Gln Pro 
             20                  25                  30
Phe Ser Lys Gly Asp Arg Leu Gly Lys Val Ala Asp Trp Thr Gly Ala 
         35                  40                  45
Thr Tyr Gln Asp Lys Arg Tyr Thr Asn Lys Tyr Ser Ser Gln Phe Gly 
     50                  55                  60
Gly Gly Ser Gln Tyr Ala Tyr Phe His Glu Glu Asp Glu Thr Ser Phe 
 65                  70                  75                  80
Gln Leu Val Asp Thr Ala Arg Thr Gln Lys Thr Ala Tyr Gln Arg Asn 
                 85                  90                  95
Arg Met Arg Phe Ala Gln Arg Asn Leu Arg Arg Asp Lys Asp Arg Arg 
             100                105                110
Asn Met Val Gln Phe Asn Leu Gln Thr Leu Pro Lys Ser Ala Lys Gln 
         115                120                125
Lys Glu Arg Glu Arg Ile Arg Leu Gln Lys Lys Phe Gln Lys Gln Phe 
     130                135                140
Gly Val Arg Gln Lys Trp Asp Gln Lys Ser Gln Lys Pro Arg Asp Ser 
 145                150                155                160
Ser Val Glu Val Arg Ser Asp Trp Glu Val Lys Glu Glu Met Asp Phe 
                 165                170                175
Pro Gln Leu Met Lys Met Arg Tyr Leu Glu Val Ser Glu Pro Gln Asp 
             180                185                190
Ile Glu Cys Cys Gly Pro Trp Ser Thr Thr Thr Lys Pro Leu Thr Ala 
         195                200                205
Ser Pro Gln Gly Val Arg Ser Pro Cys Asp Ile Lys Arg Ile Phe His 
     210                215                220
Thr Val Thr Thr Thr Asp Asp Pro Val Ile Arg Lys Leu Ala Lys Thr 
 225                230                235                240
Gln Gly Asn Val Phe Ala Thr Asp Ala Ile Leu Ala Thr Leu Met Ser 
                 245                250                255
Cys Thr Arg Ser Val Tyr Ser Trp Asp Ile Val Val Gln Arg Val Gly 
             260                265                270
Ser Lys Leu Phe Phe Asp Lys Arg Asp Asn Ser Asp Phe Asp Leu Leu 
         275                280                285
Thr Val Ser Glu Thr Ala Asn Glu Pro Pro Gln Asp Glu Gly Asn Ser 
     290                295                300
Phe Asn Ser Pro Arg Asn Leu Ala Met Glu Ala Thr Tyr Ile Asn His 
 305                310                315                320
Asn Phe Ser Gln Gln Cys Leu Arg Met Gly Arg Glu Arg Tyr Asn Phe 
                 325                330                335
Pro Asn Pro Asn Pro Phe Val Glu Asp Asp Met Asp Lys Asn Glu Ile 
             340                345                350
Ala Ser Val Ala Tyr Arg Tyr Arg Arg Trp Lys Leu Gly Asp Asp Ile 
         355                360                365
Asp Leu Ile Val Arg Cys Glu His Asp Gly Val Met Thr Gly Ala Asn 
     370                375                380
Gly Glu Val Ser Phe Ile Asn Ile Lys Thr Leu Asn Glu Trp Asp Ser 
 385                390                395                400
Arg His Cys Asn Gly Val Asp Trp Arg Gln Lys Leu Asp Ser Gln Arg 
                 405                410                415
Gly Ala Val Ile Ala Thr Glu Leu Lys Asn Asn Ser Tyr Lys Leu Ala 
             420                425                430
Arg Trp Thr Cys Cys Ala Leu Leu Ala Gly Ser Glu Tyr Leu Lys Leu 
         435                440                445
Gly Tyr Val Ser Arg Tyr His Val Lys Asp Ser Ser Arg His Val Ile 
     450                455                460
Leu Gly Thr Gln Gln Phe Lys Pro Asn Glu Phe Ala Ser Gln Ile Asn 
 465                470                475                480
Leu Ser Val Glu Asn Ala Trp Gly Ile Leu Arg Cys Val Ile Asp Ile 
                 485                490                495
Cys Met Lys Leu Glu Glu Gly Lys Tyr Leu Ile Leu Lys Asp Pro Asn 
             500                505                510
Lys Gln Val Ile Arg Val Tyr Ser Leu Pro Asp Gly Thr Phe Ser Ser 
         515                520                525
Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
     530                535                540
Glu Glu Thr 
 545



<210> 5451
<211> 456
<212> DNA
<213> Homo sapiens
<308> BE122841
<400> 5451

ttttttttc  acagacaaa  aaagtttat  gaatacaaa  ctcaaaggc  tcaacagtc  60
tgggcccaa  agatccatg  caggaagtc  agagttctg  ttcagggtc  gtctgggca  120
ccctggaag  agtcattgc  catgacagt  atgagtgcc  ggaaaacag  atactcctg  180
aagtccacc  gctggtcac  gttctcatc  aggctgccc  tcagcttct  cagcccctc  240
tcatccact  tctccccca  aaagctggg  agctccttg  gcagaagtt  cagcttctg  300
cgccagtca  cgccattac  gtgcctgga  tcccactca  tgagtgtct  gatgttgat  360
aaggacact  ccccgttgg  tccagtcat  acgccatcg  gctcacaac  gacaataag  420
tcaatatca  ctccaagct  cacctgcgg  aacggt  456



<210> 5452
<211> 97
<212> PRT
<213> Homo sapiens
<308> P29034
<400> 5452

Met Cys Ser Ser Leu Glu Gln Ala Leu Ala Val Leu Val Thr Thr Phe 
  1               5                  10                  15
His Lys Tyr Ser Cys Gln Glu Gly Asp Lys Phe Lys Leu Ser Lys Gly 
             20                  25                  30
Glu Met Lys Glu Leu Leu His Lys Glu Leu Pro Ser Phe Val Gly Glu 
         35                  40                  45
Lys Val Asp Glu Glu Gly Leu Lys Lys Leu Met Gly Ser Leu Asp Glu 
     50                  55                  60
Asn Ser Asp Gln Gln Val Asp Phe Gln Glu Tyr Ala Val Phe Leu Ala 
 65                  70                  75                  80
Leu Ile Thr Val Met Cys Asn Asp Phe Phe Gln Gly Cys Pro Asp Arg 
                 85                  90                  95
Pro 
             100



<210> 5453
<211> 614
<212> DNA
<213> Rattus norvegicus
<308> AA891553
<400> 5453

aattttatt  cttctgcta  agaacagga  ctggacaca  gctgcccag  cacagctag  60
tgctaacac  cgcaggcac  aggccaact  acttaagtt  cttcctctt  ttcttcttc  120
tcctcttcc  cctcatcct  ttcgtcctc  tcagagctg  aggtgccat  aggcaagct  180
tagactcgg  tgacctgct  gttggggtc  ttgaggatg  ggtatttgc  ctcctccag  240
ttcatgcag  tatcaatga  acagcgcag  atgccccag  cattctcca  actcaggtt  300
atttggctg  caaactcat  gggcttaaa  tgctgggtg  ccaggatga  gtggcgcga  360
gagtccttt  catggtacc  ggacacata  ccgagcttc  agtactcag  gccagccag  420
aaagcacag  acgtccatc  cgccaactt  tagctgttg  tcttcaact  agtggcgat  480
acagcccca  gctgagagt  cagcttctg  cgccagtca  cgccattac  atgcctgga  540
tcccattca  tgagtgtct  gatgttgat  aaggacact  ccccgttgg  cccagtcat  600
acgccatca  gttc  614



<210> 5454
<211> 547
<212> PRT
<213> Rattus norvegicus
<308> NP_061219
<400> 5454

Met Ala Lys Phe Met Thr Pro Val Ile Gln Asp Asn Pro Ser Gly Trp 
  1               5                  10                  15
Gly Pro Cys Ala Val Pro Glu Gln Phe Arg Asp Met Pro Tyr Gln Pro 
             20                  25                  30
Phe Ser Lys Gly Asp Arg Leu Gly Lys Val Ala Asp Trp Thr Gly Ala 
         35                  40                  45
Thr Tyr Gln Asp Lys Arg Tyr Thr Asn Lys Tyr Ser Ser Gln Phe Gly 
     50                  55                  60
Gly Gly Ser Gln Tyr Ala Tyr Phe His Glu Glu Asp Glu Thr Ser Phe 
 65                  70                  75                  80
Gln Leu Val Asp Thr Ala Arg Thr Gln Lys Thr Ala Tyr Gln Arg Asn 
                 85                  90                  95
Arg Met Arg Phe Ala Gln Arg Asn Leu Arg Arg Asp Lys Asp Arg Arg 
             100                105                110
Asn Met Val Gln Phe Asn Leu Gln Thr Leu Pro Lys Ser Ala Lys Gln 
         115                120                125
Lys Glu Arg Glu Arg Ile Arg Leu Gln Lys Lys Phe Gln Lys Gln Phe 
     130                135                140
Gly Val Arg Gln Lys Trp Asp Gln Lys Ser Gln Lys Pro Arg Asp Ser 
 145                150                155                160
Ser Val Glu Val Arg Ser Asp Trp Glu Val Lys Glu Glu Met Asp Phe 
                 165                170                175
Pro Gln Leu Met Lys Met Arg Tyr Leu Glu Val Ser Glu Pro Gln Asp 
             180                185                190
Ile Glu Cys Cys Gly Pro Trp Ser Thr Thr Thr Lys Pro Leu Thr Ala 
         195                200                205
Ser Pro Gln Gly Val Arg Ser Pro Cys Asp Ile Lys Arg Ile Phe His 
     210                215                220
Thr Val Thr Thr Thr Asp Asp Pro Val Ile Arg Lys Leu Ala Lys Thr 
 225                230                235                240
Gln Gly Asn Val Phe Ala Thr Asp Ala Ile Leu Ala Thr Leu Met Ser 
                 245                250                255
Cys Thr Arg Ser Val Tyr Ser Trp Asp Ile Val Val Gln Arg Val Gly 
             260                265                270
Ser Lys Leu Phe Phe Asp Lys Arg Asp Asn Ser Asp Phe Asp Leu Leu 
         275                280                285
Thr Val Ser Glu Thr Ala Asn Glu Pro Pro Gln Asp Glu Gly Asn Ser 
     290                295                300
Phe Asn Ser Pro Arg Asn Leu Ala Met Glu Ala Thr Tyr Ile Asn His 
 305                310                315                320
Asn Phe Ser Gln Gln Cys Leu Arg Met Gly Arg Glu Arg Tyr Asn Phe 
                 325                330                335
Pro Asn Pro Asn Pro Phe Val Glu Asp Asp Met Asp Lys Asn Glu Ile 
             340                345                350
Ala Ser Val Ala Tyr Arg Tyr Arg Arg Trp Lys Leu Gly Asp Asp Ile 
         355                360                365
Asp Leu Ile Val Arg Cys Glu His Asp Gly Val Met Thr Gly Ala Asn 
     370                375                380
Gly Glu Val Ser Phe Ile Asn Ile Lys Thr Leu Asn Glu Trp Asp Ser 
 385                390                395                400
Arg His Cys Asn Gly Val Asp Trp Arg Gln Lys Leu Asp Ser Gln Arg 
                 405                410                415
Gly Ala Val Ile Ala Thr Glu Leu Lys Asn Asn Ser Tyr Lys Leu Ala 
             420                425                430
Arg Trp Thr Cys Cys Ala Leu Leu Ala Gly Ser Glu Tyr Leu Lys Leu 
         435                440                445
Gly Tyr Val Ser Arg Tyr His Val Lys Asp Ser Ser Arg His Val Ile 
     450                455                460
Leu Gly Thr Gln Gln Phe Lys Pro Asn Glu Phe Ala Ser Gln Ile Asn 
 465                470                475                480
Leu Ser Val Glu Asn Ala Trp Gly Ile Leu Arg Cys Val Ile Asp Ile 
                 485                490                495
Cys Met Lys Leu Glu Glu Gly Lys Tyr Leu Ile Leu Lys Asp Pro Asn 
             500                505                510
Lys Gln Val Ile Arg Val Tyr Ser Leu Pro Asp Gly Thr Phe Ser Ser 
         515                520                525
Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
     530                535                540
Glu Glu Thr 
 545



<210> 5455
<211> 456
<212> DNA
<213> Homo sapiens
<308> BE122841
<400> 5455

ttttttttc  acagacaaa  aaagtttat  gaatacaaa  ctcaaaggc  tcaacagtc  60
tgggcccaa  agatccatg  caggaagtc  agagttctg  ttcagggtc  gtctgggca  120
ccctggaag  agtcattgc  catgacagt  atgagtgcc  ggaaaacag  atactcctg  180
aagtccacc  gctggtcac  gttctcatc  aggctgccc  tcagcttct  cagcccctc  240
tcatccact  tctccccca  aaagctggg  agctccttg  gcagaagtt  cagcttctg  300
cgccagtca  cgccattac  gtgcctgga  tcccactca  tgagtgtct  gatgttgat  360
aaggacact  ccccgttgg  tccagtcat  acgccatcg  gctcacaac  gacaataag  420
tcaatatca  ctccaagct  cacctgcgg  aacggt  456



<210> 5456
<211> 97
<212> PRT
<213> Homo sapiens
<308> P29034
<400> 5456

Met Cys Ser Ser Leu Glu Gln Ala Leu Ala Val Leu Val Thr Thr Phe 
  1               5                  10                  15
His Lys Tyr Ser Cys Gln Glu Gly Asp Lys Phe Lys Leu Ser Lys Gly 
             20                  25                  30
Glu Met Lys Glu Leu Leu His Lys Glu Leu Pro Ser Phe Val Gly Glu 
         35                  40                  45
Lys Val Asp Glu Glu Gly Leu Lys Lys Leu Met Gly Ser Leu Asp Glu 
     50                  55                  60
Asn Ser Asp Gln Gln Val Asp Phe Gln Glu Tyr Ala Val Phe Leu Ala 
 65                  70                  75                  80
Leu Ile Thr Val Met Cys Asn Asp Phe Phe Gln Gly Cys Pro Asp Arg 
                 85                  90                  95
Pro 
             100



<210> 5457
<211> 410
<212> DNA
<213> Rattus norvegicus
<308> AA891578
<400> 5457

aatacatgt  agaataata  tgtgcaata  aatcattca  gtgtacatg  cactaaaat  60
gaaacaaaa  tgtccaggc  aatgaaagg  accagcagg  gggtgaagg  agagaaaga  120
gaaagtaaa  gtgtgtaaa  agtgcacat  gcatacatg  gtgtaaata  tgtaatgtg  180
tgtacatgt  tgcaattat  gtcacagga  atgatgtac  tgtatgtaa  tgccttcat  240
aaacccacc  ctatggatc  tgcatatgt  atatgcaaa  aatgtgcag  aacggatga  300
agattgtta  tcaggcagg  gagtgtgct  tagtctagt  tgtcctcca  gtctattac  360
ttcttatcg  agaaatcca  gaagagcag  ctctggatc  gaaaagccat  410



<210> 5458
<211> 471
<212> DNA
<213> Rattus norvegicus
<308> AA891595
<400> 5458

gagcaagta  attaaaaac  gtcatacat  aaatagtct  acactgaca  aagtattac  60
cgtaaaata  tgcacttct  tccccataa  gcaagctgc  tcctatgag  tggtaaaca  120
tgttctttc  ttagttaaa  atagaaaag  gctgagatt  ggagggaga  aaaattaaa  180
taaggcatt  aaaatgggt  aagttgcct  tcttaagca  tagaaaact  gaataatta  240
cttcaaatt  cttgttaca  ttattgttt  cacaaacat  cagctcctt  tcaggtaca  300
gagtgaagg  tataaactc  aacatcatg  ctttataca  gtgcatagt  gcaactgaa  360
taatgatat  tgattaacg  gtattaaaa  ataaaacgg  aagttaaaa  aatcttgca  420
tattacagt  caatgtgtt  atgtgtatg  gtgtatgtg  atatatata  g  471



<210> 5459
<211> 6401
<212> DNA
<213> Homo sapiens
<308> XM_038377
<400> 5459

caaggcggc  ggcggcgac  atggcagcg  gccggcggc  gccgtagtg  cccaggcct  60
ggcttcagc  tcccggggc  ccagagggc  gggcggtcc  ggccgcggc  gtggcggcg  120
cacttccct  ctcccgccc  aggactcct  cgggcactc  ctgaggacc  gcggaccgg  180
ggcgcgaat  tgactgagg  gcggggacg  cgtctgttc  ccgccgctc  cggcagggc  240
gggccgggc  gggccgggc  gggccgggc  ggcccctgg  agcagcccc  aggcggggg  300
ccgccttgg  gacccgaag  cggagctag  ggcaggcgg  gggcccggg  ggagtcccg  360
ccggagctg  tggttcggg  gcggtgcta  gccccgagg  tgcgggacc  gagcgcgag  420
agcctgagt  cgggtccag  ggtggcggc  tgagccggc  cccgccgac  gggaaaatg  480
ccggcgccc  cgagaccgc  ccgggggac  gggcaggcg  gagccgcca  aggaagctg  540
aggcgctga  ccgagaccc  cgctccccc  tcaacgtgg  gagcttgct  gatggctta  600
attccttgg  ccttgattt  gattttcct  ctttgagga  aaacaagaa  atagataat  660
tcttaaata  atatgagaa  attgtgaaa  aaatcagag  tctacagat  aaggcagaa  720
actatgatg  tgtaaaagt  attggaaga  gtgcttttg  tgaagtgca  ttggttcgt  780
acaaggcat  gcagaaggt  tatgctatg  agcttctta  taagtttga  atgataaaa  840
gatcagatt  tgccttttt  tgggaagaa  gagatatta  ggcctttgc  aatagcccc  900
gggtggttc  gctttttta  gcctttcaa  atgataggt  tctgtacat  gtaatggag  960
acatgcctg  tggagacct  gtaaacctt  tgagtaatt  tgatgtgcc  gaaaaatgg  1020
ccaaatttt  cactgctga  gttgttctt  ctctggatg  aatacactc  atgggttta  1080
tacacagag  tgtgaagcc  gacaacatg  tcttggata  acatggaca  ctaaaatta  1140
cagattttg  cacgtgtat  aagatggat  aaacaggca  ggtacattg  gatacagca  1200
ttggaacac  ggattatat  tcacctgag  ttctgaaat  acaaggggg  gatggtttc  1260
atgggcgag  atgtgattg  tggtctgta  gtgttttcc  ttatgagat  ctagtgggg  1320
atactccat  ttatgcgga  tcacttgta  gaacatata  caaaattat  gatcataag  1380
attcactgt  tttccctga  gatgcagaa  tttccaaac  tgcaaagaa  ctcatctgt  1440
ctttcttaa  agataggga  gtacgactt  ggagaaatg  ggtggaaga  atcagacag  1500
atcctttct  taagaatga  cagtggcat  gggataaca  aagagaaac  gcagctcct  1560
tagtacctg  actcagcag  gacatagac  gcagcaatt  cgatgacat  gaagatgac  1620
aaggagatg  agaaacctt  ccaattcct  aagcttttg  tggaaatca  ctgcctttc  1680
tcggattta  ctactatag  gaaaattta  tattaagtg  ctctccatc  tgtagagaa  1740
ctgattcca  acaatcaag  aaaaatgaa  aaagtcaag  gattcagaa  aaactgtat  1800
cattagaag  acatcttag  aatgagatg  aagccaaag  ggaactgga  cagaagtgc  1860
aatctgtta  tactcgcct  gaaaaaaca  caaaggagc  agaagagga  attacctta  1920
ggaaaagtg  ggaatcagc  ttaagacag  tagaaagag  aaaggcgct  cttcagcac  1980
aaaatgcag  atatcagag  aaagctgat  atgaagcag  caaaaaacg  aatttggaa  2040
atgatgtta  cagcttaaa  gatcaactt  aagatttga  aaaaagaaa  caaaactct  2100
aaatatcca  tgagaaagt  aatcaactc  agagacaac  ggatgaaac  aatgcttta  2160
tgcgaacag  gtctgatac  gcagcccgg  taaggaaaa  ccaggcaga  agttcaaaa  2220
agattcagc  gctggaatc  aacaataga  atctacaag  taaaaactg  ctgctggag  2280
ctgccaagt  aaaacttga  aaggaattt  tcaatcttc  gtcagctct  gaatctgaa  2340
ggagggatc  aacccatgg  tcagagata  ttaatgatt  acaaggtag  atatgtggc  2400
tagaagaag  tttaaagaa  ggcaaaatc  tactagcga  agtagaact  gagaagaga  2460
aacttcagg  gagatttac  gatttggaa  aggaaaaaa  caacatgga  atagatatg  2520
cataccaac  aaaagttat  cagcagagc  tagaacaag  agaagctga  cataaggcc  2580
caaaggcac  actagcaga  aaaaataag  tctatgagt  catcgaaga  gccaaatca  2640
aagccatga  agaaatgga  aagaagctc  tggaggaaa  aactttaaa  cagaaagtg  2700
agaacctat  gctagaagc  gagaaaaga  gttctctat  agactgtga  ctcaaacag  2760
cacagcaga  aataaatga  ctccttaaa  agaaagatg  gctaaatga  gatgttaga  2820
acctgacat  aaaaataga  caagaaact  agaagcgct  ccttacaca  aatgacctg  2880
agatgcaaa  acaacaggt  aacacacta  aaatgtcag  aaagcagtt  aagcaagaa  2940
ataaccatc  catggaaat  aaaatgaac  tggaaaaac  aaatgctga  cttcgaaaa  3000
aacgtcagg  tgcagatgg  caaatgaaa  agctccagg  tcagctcga  gcagaacag  3060
atttctcaa  cctttataa  acacaagtt  gggagctta  agaagaatg  gaagaaaag  3120
ccaaacttg  taaagaatt  cagcagaag  aacaggaat  acaggatga  cgggactct  3180
tggctgccc  actggagat  accttgacc  aagcagatt  tgagcaact  gctcgttca  3240
ttgctgaag  acaatattc  gatttggaa  aagagaaga  catgaaaga  ctggagatc  3300
aagagatga  ggctagaca  aaacaggaa  ttacggaaa  agatgctac  attgcttct  3360
ttgaggaaa  taataggac  ctaactagt  atgttgcca  tcttgcaaa  gagaaagaa  3420
aattaaata  caaattgaa  gatgttcaa  agcaactgt  aagattgaa  gatgaagaa  3480
taagcgcag  agctattaa  gcacagttt  agaagcagc  attaacaga  agaacactc  3540
aaactcaag  tgtgaataa  ttggctgag  tcatgaatc  aaaagaacc  gtcaagcgt  3600
gtaatgaca  agatgtgcg  agaaaagag  aggagaata  aaagctaca  atggagctt  3660
aatctgaac  tgagaaatt  acccagcag  tgatcaagt  tcagaaaga  ctgaatgaa  3720
tgcaggcac  aatagctga  gagagccag  ttcgaattg  actgcagat  acattggac  3780
gtaaagaca  tgacattga  cagctgcgg  cacaactcc  agccttgca  attggtctg  3840
atagttcca  tataggcag  ggaccaggg  atgctgagg  agatgatgg  tttccagaa  3900
caagattag  aggatggct  tcattgcct  tacgaaaca  cactaagaa  tttggatgg  3960
ttaaaaagt  tgtgattgt  agcagtaag  agattcttt  ctatgacag  gaacaagat  4020
aagaacaat  caatcctta  atggtttta  atatagaca  gttatttca  gtccgacca  4080
ttacacaga  agatgtgta  agagcagat  ctaaagaaa  tccaaggat  ttccagatt  4140
tgtatgcca  tgaaggaga  agtaagaag  aacaagaat  tccagtgga  ccagttgga  4200
aaaaatcta  ttatatttg  cacaaggga  atgagttta  tcctactct  tatcatttc  4260
caaccaact  tgaggcttg  atgaagccc  tgtggcaca  gtttaagcc  cctcctgct  4320
tggagtgcc  ccgttgcca  attaagtgt  ataaagatc  tatggacaa  aaggaggag  4380
ttatagcac  ttgcaaagt  tattatgat  tttcaacgg  aaagaatct  ttattacta  4440
caaattcta  agaagagca  cagaagtgg  ttagtcggt  ggtgaaaaa  atacctaaa  4500
agcccccag  tccagaccc  tttgcccga  catctccta  aacttcaat  aagatacag  4560
aaaaccagt  tattagacg  ccaagtcga  agcttgccc  aaacaaacc  agctaactg  4620
cttctatga  agcagtcat  attcaaggt  atcgtattc  tccagtgaa  acaagactg  4680
aatatgatg  cccaaaatt  attaaaaag  tatattttc  tgagagact  atacataca  4740
tcatacata  atgtgttcc  cttttccct  taatataaa  tacaaatct  ggctccttt  4800
aagcaacag  ttgaaccaa  aatgattgg  tgatagact  aggatatat  caactcttc  4860
agacttttc  ataaagctc  ctcggcagt  gctcacact  caatgcaca  aaggattga  4920
aagagttaa  ggctaaaga  aacatcttt  ctagcttca  cagagaggt  tcaccagca  4980
atttaccag  agaatctgg  aatggattc  actacagtg  tattgactg  atctttaag  5040
agtgaccat  atactgtgt  tatatatat  aacacacac  catatatat  tatatatat  5100
gtactctaa  actgcaaga  ggtttttta  acttcccac  ttatttttt  tacacatta  5160
tcagatatc  ttacttgct  cagttgcaa  tatgcactt  tataaagcc  taatgttgg  5220
gtttatatc  ctcattcct  tgtacctga  ggaagttgc  tgttcatgt  taagcagtt  5280
ctgtaacaa  aagtttaaa  ttaattata  cagtttcct  atgcttcat  ataggcaac  5340
ttacccatt  tgaatgcct  aatttaatt  ttttcaaag  ctcagccct  tctgtatta  5400
aaaacaaaa  aagcgttta  cagctctta  gatgtaaac  agctttgtg  aagataaat  5460
gtgcactat  tttacacat  aatagttat  tcaatgtca  cctattttg  ttaacaaat  5520
tttttaaag  attattggt  atagaaaca  taatggatg  tgttggaac  aatatatcc  5580
tgatgtctg  ctattattc  ttcaactct  tttacagac  tcagtatta  tctgtgact  5640
caaaatatt  tatttgctt  aaatttgct  gctacccta  atgtgtttt  attcctggt  5700
aagacattt  tgattacat  ttcacactt  agattcaaa  tttttccca  atataaaga  5760
aactaagac  gactgtaga  gcattttaa  tatttaaat  tgatcctca  acatgcagc  5820
gtgtgtggc  gtattttag  accgggtta  gaaaactgg  aactgggaa  aagtggcct  5880
aaaggcact  aatttgatt  ttatttttt  aatgctgtc  aagttacag  ttacgcagg  5940
cattcttgc  gtattctca  gatcccaga  aagtgtgtg  tttatactg  aacaatatg  6000
agcaatggt  agcgtaaag  ttttttttt  tttttgttt  tttttatat  atgaagtct  6060
ttaacagtc  ctctttata  aaatacaca  agtttggta  gatatttaa  tacatcatc  6120
ggccaggca  ggtggctta  gcctgtaat  ctagcactt  gggaggcca  gacgggcgg  6180
tcacctgag  tgaggagtt  aagaccagc  tgcccaaca  agtgaaact  cgtctctac  6240
aatatacaa  aattagccg  gcatgatgg  ggtggcctg  aatcccagc  acttgggag  6300
ctgagacag  agaatcgct  gaacccagg  gacggtggt  gcagtgagc  aagatcgag  6360
cactgcact  cagcctggg  agctgaaca  gactccgtc  c  6401



<210> 5460
<211> 1388
<212> PRT
<213> Homo sapiens
<308> XP_038377
<400> 5460

Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr 
  1               5                  10                  15
Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala 
             20                  25                  30
Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp 
         35                  40                  45
Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys 
     50                  55                  60
Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys 
 65                  70                  75                  80
Lys Ile Arg Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys 
                 85                  90                  95
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
             100                105                110
Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
         115                120                125
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
     130                135                140
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
 145                150                155                160
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
                 165                170                175
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys 
             180                185                190
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
         195                200                205
Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
     210                215                220
His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp 
 225                230                235                240
Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
                 245                250                255
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly 
             260                265                270
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
         275                280                285
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
     290                295                300
Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu 
 305                310                315                320
Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
                 325                330                335
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro 
             340                345                350
Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala 
         355                360                365
Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe 
     370                375                380
Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro 
 385                390                395                400
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr 
                 405                410                415
Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Thr Asp 
             420                425                430
Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys 
         435                440                445
Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu 
     450                455                460
Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr 
 465                470                475                480
Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser 
                 485                490                495
Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn 
             500                505                510
Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn 
         515                520                525
Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys 
     530                535                540
Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu 
 545                550                555                560
Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp 
                 565                570                575
Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile 
             580                585                590
Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu 
         595                600                605
Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln 
     610                615                620
Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile 
 625                630                635                640
Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys 
                 645                650                655
Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu 
             660                665                670
Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile 
         675                680                685
Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu 
     690                695                700
Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys 
 705                710                715                720
Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met 
                 725                730                735
Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn 
             740                745                750
Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu 
         755                760                765
Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val 
     770                775                780
Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr 
 785                790                795                800
Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln 
                 805                810                815
Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn 
             820                825                830
His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu 
         835                840                845
Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp 
     850                855                860
Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val 
 865                870                875                880
Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu 
                 885                890                895
Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala 
             900                905                910
Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala 
         915                920                925
Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile 
     930                935                940
Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu 
 945                950                955                960
Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg 
                 965                970                975
Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu 
             980                985                990
Asn Asn Lys Leu Lys Asp Val Gln Glu Gln Leu Ser Arg Leu Lys Asp 
         995                1000                1005
Glu Glu Ile Ser Ala Ala Ala Ile Lys Ala Gln Phe Glu Lys Gln Leu 
     1010                1015                1020
Leu Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu 
 1025                1030                1035                1040
Ile Met Asn Arg Lys Glu Pro Val Lys Arg Gly Asn Asp Thr Asp Val 
                 1045                1050                1055
Arg Arg Lys Glu Lys Glu Asn Arg Lys Leu His Met Glu Leu Lys Ser 
             1060                1065                1070
Glu Arg Glu Lys Leu Thr Gln Gln Met Ile Lys Tyr Gln Lys Glu Leu 
         1075                1080                1085
Asn Glu Met Gln Ala Gln Ile Ala Glu Glu Ser Gln Ile Arg Ile Glu 
     1090                1095                1100
Leu Gln Met Thr Leu Asp Ser Lys Asp Ser Asp Ile Glu Gln Leu Arg 
 1105                1110                1115                1120
Ser Gln Leu Gln Ala Leu His Ile Gly Leu Asp Ser Ser Ser Ile Gly 
                 1125                1130                1135
Ser Gly Pro Gly Asp Ala Glu Ala Asp Asp Gly Phe Pro Glu Ser Arg 
             1140                1145                1150
Leu Glu Gly Trp Leu Ser Leu Pro Val Arg Asn Asn Thr Lys Lys Phe 
         1155                1160                1165
Gly Trp Val Lys Lys Tyr Val Ile Val Ser Ser Lys Lys Ile Leu Phe 
     1170                1175                1180
Tyr Asp Ser Glu Gln Asp Lys Glu Gln Ser Asn Pro Tyr Met Val Leu 
 1185                1190                1195                1200
Asp Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Thr Asp Val 
                 1205                1210                1215
Tyr Arg Ala Asp Ala Lys Glu Ile Pro Arg Ile Phe Gln Ile Leu Tyr 
             1220                1225                1230
Ala Asn Glu Gly Glu Ser Lys Lys Glu Gln Glu Phe Pro Val Glu Pro 
         1235                1240                1245
Val Gly Glu Lys Ser Asn Tyr Ile Cys His Lys Gly His Glu Phe Ile 
     1250                1255                1260
Pro Thr Leu Tyr His Phe Pro Thr Asn Cys Glu Ala Cys Met Lys Pro 
 1265                1270                1275                1280
Leu Trp His Met Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys 
                 1285                1290                1295
His Ile Lys Cys His Lys Asp His Met Asp Lys Lys Glu Glu Ile Ile 
             1300                1305                1310
Ala Pro Cys Lys Val Tyr Tyr Asp Ile Ser Thr Ala Lys Asn Leu Leu 
         1315                1320                1325
Leu Leu Ala Asn Ser Thr Glu Glu Gln Gln Lys Trp Val Ser Arg Leu 
     1330                1335                1340
Val Lys Lys Ile Pro Lys Lys Pro Pro Ala Pro Asp Pro Phe Ala Arg 
 1345                1350                1355                1360
Ser Ser Pro Arg Thr Ser Met Lys Ile Gln Gln Asn Gln Ser Ile Arg 
                 1365                1370                1375
Arg Pro Ser Arg Gln Leu Ala Pro Asn Lys Pro Ser 
             1380                1385



<210> 5461
<211> 471
<212> DNA
<213> Rattus norvegicus
<308> AA891595
<400> 5461

gagcaagta  attaaaaac  gtcatacat  aaatagtct  acactgaca  aagtattac  60
cgtaaaata  tgcacttct  tccccataa  gcaagctgc  tcctatgag  tggtaaaca  120
tgttctttc  ttagttaaa  atagaaaag  gctgagatt  ggagggaga  aaaattaaa  180
taaggcatt  aaaatgggt  aagttgcct  tcttaagca  tagaaaact  gaataatta  240
cttcaaatt  cttgttaca  ttattgttt  cacaaacat  cagctcctt  tcaggtaca  300
gagtgaagg  tataaactc  aacatcatg  ctttataca  gtgcatagt  gcaactgaa  360
taatgatat  tgattaacg  gtattaaaa  ataaaacgg  aagttaaaa  aatcttgca  420
tattacagt  caatgtgtt  atgtgtatg  gtgtatgtg  atatatata  g  471



<210> 5462
<211> 1369
<212> PRT
<213> Rattus norvegicus
<308> NP_112360
<400> 5462

Met Ser Thr Gly Asp Ser Phe Glu Thr Arg Phe Glu Lys Ile Asp Asn 
  1               5                  10                  15
Leu Leu Arg Asp Pro Lys Ser Glu Val Asn Ser Asp Cys Leu Leu Asp 
             20                  25                  30
Gly Leu Asp Ala Leu Val Tyr Asp Leu Asp Phe Pro Ala Leu Arg Lys 
         35                  40                  45
Asn Lys Asn Ile Asp Asn Phe Leu Ser Arg Tyr Lys Asp Thr Ile Asn 
     50                  55                  60
Lys Ile Arg Asp Leu Arg Met Lys Ala Glu Asp Tyr Glu Val Val Lys 
 65                  70                  75                  80
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
                 85                  90                  95
Ser Thr Arg Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
             100                105                110
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
         115                120                125
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
     130                135                140
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
 145                150                155                160
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Arg 
                 165                170                175
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
             180                185                190
Gly Phe Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
         195                200                205
Ser Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asn 
     210                215                220
Lys Glu Gly Met Val Arg Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
 225                230                235                240
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Tyr Tyr Gly 
                 245                250                255
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
             260                265                270
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
         275                280                285
Lys Ile Met Asn His Lys Asn Ser Leu Thr Phe Pro Asp Asp Asn Asp 
     290                295                300
Ile Ser Lys Glu Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
 305                310                315                320
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Lys Arg His Leu 
                 325                330                335
Phe Phe Lys Asn Asp Gln Trp Ala Trp Glu Thr Leu Arg Asp Thr Val 
             340                345                350
Ala Pro Val Val Pro Asp Leu Ser Ser Asp Ile Asp Thr Ser Asn Phe 
         355                360                365
Asp Asp Leu Glu Glu Asp Lys Gly Asp Glu Glu Thr Phe Pro Ile Pro 
     370                375                380
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Val Gly Phe Thr Tyr Tyr 
 385                390                395                400
Ser Asn Arg Arg Tyr Leu Pro Ser Ala Asn Pro Ser Glu Asn Arg Ser 
                 405                410                415
Ser Ser Asn Val Asp Lys Asn Val Gln Glu Ser Leu Gln Lys Thr Ile 
             420                425                430
Tyr Lys Leu Glu Glu Gln Leu His Asn Glu Met Gln Leu Lys Asp Glu 
         435                440                445
Met Glu Gln Lys Cys Arg Thr Ser Asn Ile Lys Leu Asp Lys Ile Met 
     450                455                460
Lys Glu Leu Asp Glu Glu Gly Asn Gln Arg Arg Asn Leu Glu Ser Ala 
 465                470                475                480
Val Ser Gln Ile Glu Lys Glu Lys Met Leu Leu Gln His Arg Ile Asn 
                 485                490                495
Glu Tyr Gln Arg Lys Val Glu Gln Glu Asn Glu Lys Arg Arg Asn Val 
             500                505                510
Glu Asn Glu Val Ser Thr Leu Lys Asp Gln Leu Glu Asp Leu Arg Lys 
         515                520                525
Ala Ser Gln Ser Ser Gln Leu Ala Asn Glu Lys Leu Thr Gln Leu Gln 
     530                535                540
Lys Gln Leu Glu Glu Ala Asn Asp Leu Leu Arg Thr Glu Ser Asp Thr 
 545                550                555                560
Ala Val Arg Leu Arg Lys Ser His Thr Glu Met Ser Lys Ser Val Ser 
                 565                570                575
Gln Leu Glu Ser Leu Asn Arg Glu Leu Gln Glu Arg Asn Arg Met Leu 
             580                585                590
Glu Asn Ser Lys Ser Gln Ala Asp Lys Asp Tyr Tyr Gln Leu Gln Ala 
         595                600                605
Val Leu Glu Ala Glu Arg Arg Asp Arg Gly His Asp Ser Glu Met Ile 
     610                615                620
Gly Asp Leu Gln Ala Arg Ile Thr Ser Leu Gln Glu Glu Val Lys His 
 625                630                635                640
Leu Lys His Asn Leu Glu Arg Val Glu Gly Glu Arg Lys Glu Ala Gln 
                 645                650                655
Asp Met Leu Asn His Ser Glu Lys Glu Lys Asn Asn Leu Glu Ile Asp 
             660                665                670
Leu Asn Tyr Lys Leu Lys Ser Ile Gln Gln Arg Leu Glu Gln Glu Val 
         675                680                685
Asn Glu His Lys Val Thr Lys Ala Arg Leu Thr Asp Lys His Gln Ser 
     690                695                700
Ile Glu Glu Ala Lys Ser Val Ala Met Cys Glu Met Glu Lys Lys Leu 
 705                710                715                720
Lys Glu Glu Arg Glu Ala Arg Glu Lys Ala Glu Asn Arg Val Val Glu 
                 725                730                735
Thr Glu Lys Gln Cys Ser Met Leu Asp Val Asp Leu Lys Gln Ser Gln 
             740                745                750
Gln Lys Leu Glu His Leu Thr Glu Asn Lys Glu Arg Leu Glu Asp Ala 
         755                760                765
Val Lys Ser Leu Thr Leu Gln Leu Glu Gln Glu Ser Asn Lys Arg Ile 
     770                775                780
Leu Leu Gln Ser Glu Leu Lys Thr Gln Ala Phe Glu Ala Asp Asn Leu 
 785                790                795                800
Lys Gly Leu Glu Lys Gln Met Lys Gln Glu Ile Asn Thr Leu Leu Glu 
                 805                810                815
Ala Lys Arg Leu Leu Glu Phe Glu Leu Ala Gln Leu Thr Lys Gln Tyr 
             820                825                830
Arg Gly Asn Glu Gly Gln Met Arg Glu Leu Gln Asp Gln Leu Glu Ala 
         835                840                845
Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val Lys Glu Leu Lys 
     850                855                860
Glu Glu Ile Glu Glu Lys Asn Arg Glu Asn Leu Arg Lys Ile Gln Glu 
 865                870                875                880
Leu Gln Ser Glu Lys Glu Thr Leu Ser Thr Gln Leu Asp Leu Ala Glu 
                 885                890                895
Thr Lys Ala Glu Ser Glu Gln Leu Ala Arg Gly Ile Leu Glu Glu Gln 
             900                905                910
Tyr Phe Glu Leu Thr Gln Glu Ser Lys Lys Ala Ala Ser Arg Asn Arg 
         915                920                925
Gln Glu Ile Thr Asp Lys Asp His Thr Val Ser Arg Leu Glu Glu Ala 
     930                935                940
Asn Asn Ala Leu Thr Lys Asp Ile Glu Leu Leu Arg Lys Glu Asn Glu 
 945                950                955                960
Glu Leu Asn Glu Arg Met Arg Thr Ala Glu Glu Glu Tyr Lys Leu Lys 
                 965                970                975
Lys Glu Glu Glu Ile Ser Asn Leu Lys Ala Ala Phe Glu Lys Asn Ile 
             980                985                990
Ser Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu 
         995                1000                1005
Ile Met Asn Arg Lys Asp Phe Lys Ile Asp Arg Lys Lys Ala Asn Thr 
     1010                1015                1020
Gln Asp Leu Arg Lys Lys Glu Lys Glu Asn Arg Lys Leu Gln Leu Glu 
 1025                1030                1035                1040
Leu Asn Gln Glu Arg Glu Lys Phe Asn Gln Met Val Val Lys His Gln 
                 1045                1050                1055
Lys Glu Leu Asn Asp Met Gln Ala Gln Leu Val Glu Glu Cys Thr His 
             1060                1065                1070
Arg Asn Glu Leu Gln Met Gln Leu Ala Ser Lys Glu Ser Asp Ile Glu 
         1075                1080                1085
Gln Leu Arg Ala Lys Leu Leu Asp Leu Ser Asp Ser Thr Ser Val Ala 
     1090                1095                1100
Ser Phe Pro Ser Ala Asp Glu Thr Asp Gly Asn Leu Pro Val Gly Ser 
 1105                1110                1115                1120
Ala Cys Ile Pro Tyr Leu Phe Ile Phe Tyr Ser Ser Ser Ser Arg Ile 
                 1125                1130                1135
Glu Gly Trp Leu Ser Val Pro Asn Arg Gly Asn Ile Lys Arg Tyr Gly 
             1140                1145                1150
Trp Lys Lys Gln Tyr Val Val Val Ser Ser Lys Lys Met Leu Phe Tyr 
         1155                1160                1165
Asn Asp Glu Gln Asp Lys Glu Gln Ser Ser Pro Ser Met Val Leu Asp 
     1170                1175                1180
Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Gly Asp Val Tyr 
 1185                1190                1195                1200
Arg Ala Glu Thr Glu Glu Ile Pro Lys Ile Phe Gln Ile Leu Tyr Ala 
                 1205                1210                1215
Asn Glu Gly Glu Cys Arg Lys Asp Ile Glu Val Glu Pro Val Gln Gln 
             1220                1225                1230
Gly Glu Lys Thr Asn Phe Gln Asn His Lys Gly His Glu Phe Ile Pro 
         1235                1240                1245
Thr Leu Tyr His Phe Pro Ala Asn Cys Glu Ala Cys Ala Lys Pro Leu 
     1250                1255                1260
Trp His Val Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys His 
 1265                1270                1275                1280
Val Lys Ser His Arg Asp His Leu Asp Lys Lys Glu Asp Leu Ile Pro 
                 1285                1290                1295
Pro Cys Lys Val Ser Tyr Asp Val Thr Ser Ala Arg Asp Met Leu Leu 
             1300                1305                1310
Leu Ala Cys Pro Gln Asp Glu Gln Lys Lys Trp Val Thr His Leu Val 
         1315                1320                1325
Lys Lys Ile Pro Lys Lys Ala Pro Ser Gly Phe Val Arg Ala Ser Pro 
     1330                1335                1340
Arg Thr Leu Ser Thr Arg Ser Thr Ala Asn Gln Ser Phe Arg Lys Val 
 1345                1350                1355                1360
Val Lys Asn Thr Ser Gly Lys Thr Ser 
                 1365



<210> 5463
<211> 6401
<212> DNA
<213> Homo sapiens
<308> XM_038377
<400> 5463

caaggcggc  ggcggcgac  atggcagcg  gccggcggc  gccgtagtg  cccaggcct  60
ggcttcagc  tcccggggc  ccagagggc  gggcggtcc  ggccgcggc  gtggcggcg  120
cacttccct  ctcccgccc  aggactcct  cgggcactc  ctgaggacc  gcggaccgg  180
ggcgcgaat  tgactgagg  gcggggacg  cgtctgttc  ccgccgctc  cggcagggc  240
gggccgggc  gggccgggc  gggccgggc  ggcccctgg  agcagcccc  aggcggggg  300
ccgccttgg  gacccgaag  cggagctag  ggcaggcgg  gggcccggg  ggagtcccg  360
ccggagctg  tggttcggg  gcggtgcta  gccccgagg  tgcgggacc  gagcgcgag  420
agcctgagt  cgggtccag  ggtggcggc  tgagccggc  cccgccgac  gggaaaatg  480
ccggcgccc  cgagaccgc  ccgggggac  gggcaggcg  gagccgcca  aggaagctg  540
aggcgctga  ccgagaccc  cgctccccc  tcaacgtgg  gagcttgct  gatggctta  600
attccttgg  ccttgattt  gattttcct  ctttgagga  aaacaagaa  atagataat  660
tcttaaata  atatgagaa  attgtgaaa  aaatcagag  tctacagat  aaggcagaa  720
actatgatg  tgtaaaagt  attggaaga  gtgcttttg  tgaagtgca  ttggttcgt  780
acaaggcat  gcagaaggt  tatgctatg  agcttctta  taagtttga  atgataaaa  840
gatcagatt  tgccttttt  tgggaagaa  gagatatta  ggcctttgc  aatagcccc  900
gggtggttc  gctttttta  gcctttcaa  atgataggt  tctgtacat  gtaatggag  960
acatgcctg  tggagacct  gtaaacctt  tgagtaatt  tgatgtgcc  gaaaaatgg  1020
ccaaatttt  cactgctga  gttgttctt  ctctggatg  aatacactc  atgggttta  1080
tacacagag  tgtgaagcc  gacaacatg  tcttggata  acatggaca  ctaaaatta  1140
cagattttg  cacgtgtat  aagatggat  aaacaggca  ggtacattg  gatacagca  1200
ttggaacac  ggattatat  tcacctgag  ttctgaaat  acaaggggg  gatggtttc  1260
atgggcgag  atgtgattg  tggtctgta  gtgttttcc  ttatgagat  ctagtgggg  1320
atactccat  ttatgcgga  tcacttgta  gaacatata  caaaattat  gatcataag  1380
attcactgt  tttccctga  gatgcagaa  tttccaaac  tgcaaagaa  ctcatctgt  1440
ctttcttaa  agataggga  gtacgactt  ggagaaatg  ggtggaaga  atcagacag  1500
atcctttct  taagaatga  cagtggcat  gggataaca  aagagaaac  gcagctcct  1560
tagtacctg  actcagcag  gacatagac  gcagcaatt  cgatgacat  gaagatgac  1620
aaggagatg  agaaacctt  ccaattcct  aagcttttg  tggaaatca  ctgcctttc  1680
tcggattta  ctactatag  gaaaattta  tattaagtg  ctctccatc  tgtagagaa  1740
ctgattcca  acaatcaag  aaaaatgaa  aaagtcaag  gattcagaa  aaactgtat  1800
cattagaag  acatcttag  aatgagatg  aagccaaag  ggaactgga  cagaagtgc  1860
aatctgtta  tactcgcct  gaaaaaaca  caaaggagc  agaagagga  attacctta  1920
ggaaaagtg  ggaatcagc  ttaagacag  tagaaagag  aaaggcgct  cttcagcac  1980
aaaatgcag  atatcagag  aaagctgat  atgaagcag  caaaaaacg  aatttggaa  2040
atgatgtta  cagcttaaa  gatcaactt  aagatttga  aaaaagaaa  caaaactct  2100
aaatatcca  tgagaaagt  aatcaactc  agagacaac  ggatgaaac  aatgcttta  2160
tgcgaacag  gtctgatac  gcagcccgg  taaggaaaa  ccaggcaga  agttcaaaa  2220
agattcagc  gctggaatc  aacaataga  atctacaag  taaaaactg  ctgctggag  2280
ctgccaagt  aaaacttga  aaggaattt  tcaatcttc  gtcagctct  gaatctgaa  2340
ggagggatc  aacccatgg  tcagagata  ttaatgatt  acaaggtag  atatgtggc  2400
tagaagaag  tttaaagaa  ggcaaaatc  tactagcga  agtagaact  gagaagaga  2460
aacttcagg  gagatttac  gatttggaa  aggaaaaaa  caacatgga  atagatatg  2520
cataccaac  aaaagttat  cagcagagc  tagaacaag  agaagctga  cataaggcc  2580
caaaggcac  actagcaga  aaaaataag  tctatgagt  catcgaaga  gccaaatca  2640
aagccatga  agaaatgga  aagaagctc  tggaggaaa  aactttaaa  cagaaagtg  2700
agaacctat  gctagaagc  gagaaaaga  gttctctat  agactgtga  ctcaaacag  2760
cacagcaga  aataaatga  ctccttaaa  agaaagatg  gctaaatga  gatgttaga  2820
acctgacat  aaaaataga  caagaaact  agaagcgct  ccttacaca  aatgacctg  2880
agatgcaaa  acaacaggt  aacacacta  aaatgtcag  aaagcagtt  aagcaagaa  2940
ataaccatc  catggaaat  aaaatgaac  tggaaaaac  aaatgctga  cttcgaaaa  3000
aacgtcagg  tgcagatgg  caaatgaaa  agctccagg  tcagctcga  gcagaacag  3060
atttctcaa  cctttataa  acacaagtt  gggagctta  agaagaatg  gaagaaaag  3120
ccaaacttg  taaagaatt  cagcagaag  aacaggaat  acaggatga  cgggactct  3180
tggctgccc  actggagat  accttgacc  aagcagatt  tgagcaact  gctcgttca  3240
ttgctgaag  acaatattc  gatttggaa  aagagaaga  catgaaaga  ctggagatc  3300
aagagatga  ggctagaca  aaacaggaa  ttacggaaa  agatgctac  attgcttct  3360
ttgaggaaa  taataggac  ctaactagt  atgttgcca  tcttgcaaa  gagaaagaa  3420
aattaaata  caaattgaa  gatgttcaa  agcaactgt  aagattgaa  gatgaagaa  3480
taagcgcag  agctattaa  gcacagttt  agaagcagc  attaacaga  agaacactc  3540
aaactcaag  tgtgaataa  ttggctgag  tcatgaatc  aaaagaacc  gtcaagcgt  3600
gtaatgaca  agatgtgcg  agaaaagag  aggagaata  aaagctaca  atggagctt  3660
aatctgaac  tgagaaatt  acccagcag  tgatcaagt  tcagaaaga  ctgaatgaa  3720
tgcaggcac  aatagctga  gagagccag  ttcgaattg  actgcagat  acattggac  3780
gtaaagaca  tgacattga  cagctgcgg  cacaactcc  agccttgca  attggtctg  3840
atagttcca  tataggcag  ggaccaggg  atgctgagg  agatgatgg  tttccagaa  3900
caagattag  aggatggct  tcattgcct  tacgaaaca  cactaagaa  tttggatgg  3960
ttaaaaagt  tgtgattgt  agcagtaag  agattcttt  ctatgacag  gaacaagat  4020
aagaacaat  caatcctta  atggtttta  atatagaca  gttatttca  gtccgacca  4080
ttacacaga  agatgtgta  agagcagat  ctaaagaaa  tccaaggat  ttccagatt  4140
tgtatgcca  tgaaggaga  agtaagaag  aacaagaat  tccagtgga  ccagttgga  4200
aaaaatcta  ttatatttg  cacaaggga  atgagttta  tcctactct  tatcatttc  4260
caaccaact  tgaggcttg  atgaagccc  tgtggcaca  gtttaagcc  cctcctgct  4320
tggagtgcc  ccgttgcca  attaagtgt  ataaagatc  tatggacaa  aaggaggag  4380
ttatagcac  ttgcaaagt  tattatgat  tttcaacgg  aaagaatct  ttattacta  4440
caaattcta  agaagagca  cagaagtgg  ttagtcggt  ggtgaaaaa  atacctaaa  4500
agcccccag  tccagaccc  tttgcccga  catctccta  aacttcaat  aagatacag  4560
aaaaccagt  tattagacg  ccaagtcga  agcttgccc  aaacaaacc  agctaactg  4620
cttctatga  agcagtcat  attcaaggt  atcgtattc  tccagtgaa  acaagactg  4680
aatatgatg  cccaaaatt  attaaaaag  tatattttc  tgagagact  atacataca  4740
tcatacata  atgtgttcc  cttttccct  taatataaa  tacaaatct  ggctccttt  4800
aagcaacag  ttgaaccaa  aatgattgg  tgatagact  aggatatat  caactcttc  4860
agacttttc  ataaagctc  ctcggcagt  gctcacact  caatgcaca  aaggattga  4920
aagagttaa  ggctaaaga  aacatcttt  ctagcttca  cagagaggt  tcaccagca  4980
atttaccag  agaatctgg  aatggattc  actacagtg  tattgactg  atctttaag  5040
agtgaccat  atactgtgt  tatatatat  aacacacac  catatatat  tatatatat  5100
gtactctaa  actgcaaga  ggtttttta  acttcccac  ttatttttt  tacacatta  5160
tcagatatc  ttacttgct  cagttgcaa  tatgcactt  tataaagcc  taatgttgg  5220
gtttatatc  ctcattcct  tgtacctga  ggaagttgc  tgttcatgt  taagcagtt  5280
ctgtaacaa  aagtttaaa  ttaattata  cagtttcct  atgcttcat  ataggcaac  5340
ttacccatt  tgaatgcct  aatttaatt  ttttcaaag  ctcagccct  tctgtatta  5400
aaaacaaaa  aagcgttta  cagctctta  gatgtaaac  agctttgtg  aagataaat  5460
gtgcactat  tttacacat  aatagttat  tcaatgtca  cctattttg  ttaacaaat  5520
tttttaaag  attattggt  atagaaaca  taatggatg  tgttggaac  aatatatcc  5580
tgatgtctg  ctattattc  ttcaactct  tttacagac  tcagtatta  tctgtgact  5640
caaaatatt  tatttgctt  aaatttgct  gctacccta  atgtgtttt  attcctggt  5700
aagacattt  tgattacat  ttcacactt  agattcaaa  tttttccca  atataaaga  5760
aactaagac  gactgtaga  gcattttaa  tatttaaat  tgatcctca  acatgcagc  5820
gtgtgtggc  gtattttag  accgggtta  gaaaactgg  aactgggaa  aagtggcct  5880
aaaggcact  aatttgatt  ttatttttt  aatgctgtc  aagttacag  ttacgcagg  5940
cattcttgc  gtattctca  gatcccaga  aagtgtgtg  tttatactg  aacaatatg  6000
agcaatggt  agcgtaaag  ttttttttt  tttttgttt  tttttatat  atgaagtct  6060
ttaacagtc  ctctttata  aaatacaca  agtttggta  gatatttaa  tacatcatc  6120
ggccaggca  ggtggctta  gcctgtaat  ctagcactt  gggaggcca  gacgggcgg  6180
tcacctgag  tgaggagtt  aagaccagc  tgcccaaca  agtgaaact  cgtctctac  6240
aatatacaa  aattagccg  gcatgatgg  ggtggcctg  aatcccagc  acttgggag  6300
ctgagacag  agaatcgct  gaacccagg  gacggtggt  gcagtgagc  aagatcgag  6360
cactgcact  cagcctggg  agctgaaca  gactccgtc  c  6401



<210> 5464
<211> 1388
<212> PRT
<213> Homo sapiens
<308> XP_038377
<400> 5464

Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr 
  1               5                  10                  15
Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala 
             20                  25                  30
Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp 
         35                  40                  45
Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys 
     50                  55                  60
Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys 
 65                  70                  75                  80
Lys Ile Arg Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys 
                 85                  90                  95
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
             100                105                110
Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
         115                120                125
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
     130                135                140
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
 145                150                155                160
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
                 165                170                175
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys 
             180                185                190
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
         195                200                205
Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
     210                215                220
His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp 
 225                230                235                240
Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
                 245                250                255
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly 
             260                265                270
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
         275                280                285
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
     290                295                300
Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu 
 305                310                315                320
Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
                 325                330                335
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro 
             340                345                350
Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala 
         355                360                365
Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe 
     370                375                380
Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro 
 385                390                395                400
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr 
                 405                410                415
Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Thr Asp 
             420                425                430
Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys 
         435                440                445
Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu 
     450                455                460
Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr 
 465                470                475                480
Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser 
                 485                490                495
Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn 
             500                505                510
Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn 
         515                520                525
Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys 
     530                535                540
Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu 
 545                550                555                560
Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp 
                 565                570                575
Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile 
             580                585                590
Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu 
         595                600                605
Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln 
     610                615                620
Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile 
 625                630                635                640
Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys 
                 645                650                655
Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu 
             660                665                670
Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile 
         675                680                685
Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu 
     690                695                700
Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys 
 705                710                715                720
Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met 
                 725                730                735
Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn 
             740                745                750
Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu 
         755                760                765
Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val 
     770                775                780
Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr 
 785                790                795                800
Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln 
                 805                810                815
Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn 
             820                825                830
His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu 
         835                840                845
Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp 
     850                855                860
Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val 
 865                870                875                880
Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu 
                 885                890                895
Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala 
             900                905                910
Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala 
         915                920                925
Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile 
     930                935                940
Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu 
 945                950                955                960
Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg 
                 965                970                975
Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu 
             980                985                990
Asn Asn Lys Leu Lys Asp Val Gln Glu Gln Leu Ser Arg Leu Lys Asp 
         995                1000                1005
Glu Glu Ile Ser Ala Ala Ala Ile Lys Ala Gln Phe Glu Lys Gln Leu 
     1010                1015                1020
Leu Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu 
 1025                1030                1035                1040
Ile Met Asn Arg Lys Glu Pro Val Lys Arg Gly Asn Asp Thr Asp Val 
                 1045                1050                1055
Arg Arg Lys Glu Lys Glu Asn Arg Lys Leu His Met Glu Leu Lys Ser 
             1060                1065                1070
Glu Arg Glu Lys Leu Thr Gln Gln Met Ile Lys Tyr Gln Lys Glu Leu 
         1075                1080                1085
Asn Glu Met Gln Ala Gln Ile Ala Glu Glu Ser Gln Ile Arg Ile Glu 
     1090                1095                1100
Leu Gln Met Thr Leu Asp Ser Lys Asp Ser Asp Ile Glu Gln Leu Arg 
 1105                1110                1115                1120
Ser Gln Leu Gln Ala Leu His Ile Gly Leu Asp Ser Ser Ser Ile Gly 
                 1125                1130                1135
Ser Gly Pro Gly Asp Ala Glu Ala Asp Asp Gly Phe Pro Glu Ser Arg 
             1140                1145                1150
Leu Glu Gly Trp Leu Ser Leu Pro Val Arg Asn Asn Thr Lys Lys Phe 
         1155                1160                1165
Gly Trp Val Lys Lys Tyr Val Ile Val Ser Ser Lys Lys Ile Leu Phe 
     1170                1175                1180
Tyr Asp Ser Glu Gln Asp Lys Glu Gln Ser Asn Pro Tyr Met Val Leu 
 1185                1190                1195                1200
Asp Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Thr Asp Val 
                 1205                1210                1215
Tyr Arg Ala Asp Ala Lys Glu Ile Pro Arg Ile Phe Gln Ile Leu Tyr 
             1220                1225                1230
Ala Asn Glu Gly Glu Ser Lys Lys Glu Gln Glu Phe Pro Val Glu Pro 
         1235                1240                1245
Val Gly Glu Lys Ser Asn Tyr Ile Cys His Lys Gly His Glu Phe Ile 
     1250                1255                1260
Pro Thr Leu Tyr His Phe Pro Thr Asn Cys Glu Ala Cys Met Lys Pro 
 1265                1270                1275                1280
Leu Trp His Met Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys 
                 1285                1290                1295
His Ile Lys Cys His Lys Asp His Met Asp Lys Lys Glu Glu Ile Ile 
             1300                1305                1310
Ala Pro Cys Lys Val Tyr Tyr Asp Ile Ser Thr Ala Lys Asn Leu Leu 
         1315                1320                1325
Leu Leu Ala Asn Ser Thr Glu Glu Gln Gln Lys Trp Val Ser Arg Leu 
     1330                1335                1340
Val Lys Lys Ile Pro Lys Lys Pro Pro Ala Pro Asp Pro Phe Ala Arg 
 1345                1350                1355                1360
Ser Ser Pro Arg Thr Ser Met Lys Ile Gln Gln Asn Gln Ser Ile Arg 
                 1365                1370                1375
Arg Pro Ser Arg Gln Leu Ala Pro Asn Lys Pro Ser 
             1380                1385



<210> 5465
<211> 327
<212> DNA
<213> Rattus norvegicus
<308> AA891631
<400> 5465

gccagagca  agactcaag  caggtttaa  ggtcattgt  tagttccag  gcccgtggg  60
tccgaggtt  gccagcctg  tgtacacag  gggaggaag  gtcctagac  cagaaagag  120
gaattacaa  gcaaagaca  atacacacc  ggaaatcgg  tttgttctc  ccagacagg  180
ctacccttc  tggcctcct  caggggccc  atagataca  caaagaaaa  gatcacaga  240
aattacaca  actgtagag  cctgtcaca  cctgtctcc  gaggaacct  cttctcctt  300
ctgggagat  gtttatgag  atagatg  327



<210> 5466
<211> 4568
<212> DNA
<213> Homo sapiens
<308> AB032989
<400> 5466

cccattcct  gcccagtta  acagcacta  tggacctca  tcacaacaa  ctgagccgc  60
tgcgggccg  gtggacccc  acgcgcctg  cccaactgc  ctccctgct  ctgagccac  120
accacctga  cttcatctc  tctgaggcc  tttccccgg  acccaacct  cgctacctg  180
acctctcct  caaccagct  cgtacactg  atgagttcc  gttcagtga  ctgcaagta  240
tggaggtgc  gctgctcta  aataaccac  tcatggcgg  ggaccggtg  gccttcgat  300
acatggccc  gctgcagaa  ctctacttg  gccagaacc  gatctctcg  ttccctctg  360
aactggtca  ggaaggagc  aagctaccc  aactaacgc  cctggatct  tcttctaac  420
agctgaaga  cttgccatt  cctgacctg  agaagctgc  ggcctggat  aagaatggg  480
tgtacctac  taacaaccc  ctgaactgc  actgtgagc  ctaccagct  ttttcacac  540
ggcagtatc  gcagctgag  tccgtgatg  actttcaag  ggatctgta  tgcatgaac  600
ccaagaagc  gcacaatgt  ttcaacctg  gtttcctca  ctgtggcga  tacaaggag  660
gtgcctggg  ggcccacct  ggtgacacc  tgatcatca  gtgtgacac  aagcagcaa  720
ggatgacca  ggtgtgggt  acaccaagt  atgaacggg  gctagatga  gtgaccaat  780
gcacagtga  tgtgtctaa  gatggcagt  ttcttttcc  gcaggtgca  gtcgaggac  840
gtggtgtgt  tacctgcta  gccatggga  agactttca  tgagacact  tctgtggaa  900
tgaaagtgc  caatttcac  ttgcacgga  accatgaca  cctcaacac  gcctatacc  960
ccctagtgg  ctgtatcct  agtgtggtc  tggtcctca  atacctata  ctcacccct  1020
gccgctgct  gtgccgggg  gtagagaag  cttccagcc  tcaaggaga  agcctcagc  1080
cttccatgc  tagtaccac  cccaaccat  atcctatgg  tggtgggga  aaagatgat  1140
gttttgacc  gcgggtggc  ttcctggaa  ctgctggac  tgggcaggg  caaaacggc  1200
agctcaagc  aggcaacac  ctgccagtg  ctgaggcca  aggcaaggg  caacggagg  1260
tgtcggatc  agaatcagt  agctcggtc  tctctgata  gcccattgt  gtgtgagca  1320
gatgggttg  tggggagat  ctgccccag  agaggtaat  cacccctga  ggatatgag  1380
ggatggaag  gagggctgg  tgcccaagg  aatggattc  tcctgacct  aagggaatt  1440
gtcccaggt  caacagaga  caagacccc  aacagggcg  ggctgccac  attttcaaa  1500
gggggtata  taatcctca  gcaaatgct  cacccgtac  caaagccct  ccaattctc  1560
gtgtggtag  ggaagagaa  catgtctga  ttggatggg  atgaggaag  agtgagggg  1620
agaacagat  ccctaaact  tcatgaggt  atccctagc  ccttaagag  aaaacattt  1680
gaaaaaaaa  ttttttcta  ctctgccca  ccacacctg  gatgttgtg  gtgttgggg  1740
agcttccac  ggagccaca  tggggaaaa  ctgtagtat  ttctttgtt  agcaagtca  1800
acttcacag  tggggaagt  gaaaacctt  ggaaaatga  tcaggaaaa  gctgagacc  1860
caatcggta  caattcccc  aagctgttg  aagactttg  attaaagcc  ttctttttc  1920
tgatgtgcc  tgggtggat  gatctttgc  ggagcctgg  ctgctgcct  ttagttaca  1980
cagcaatgt  ggatgtggt  tctgtgcct  gtcctggga  caatggcac  gagggttat  2040
gcatgaact  aagggtcca  gtcacagca  aggtgccag  acgaaactt  tagatgggg  2100
gtgaattcc  gataggcta  ttccctggt  ggtgaaacc  ttggttagt  tttgattcc  2160
agcatctgt  tgtcaggcc  gagtggggg  tgctgaagg  agagctttt  tggatgcct  2220
ccacagacg  ggtacatgg  cccacttca  gatagaagg  tgaaggtaa  tcagcctct  2280
ttatgtagc  tccagctgg  cctagctga  tctcaatgt  tgccatctc  tcatccagt  2340
tccttatca  gctcaggtg  gattctgaa  tttccctaa  atgctgctc  gtaaaggga  2400
gagtccaag  aagcctggc  ccagctggc  tagagtagg  ttggcgata  tgaaaatcc  2460
gtatatatc  cctctgtgt  gacaaggtt  ccttgctcc  ctcagagat  ccacctctg  2520
tgcaaagtc  aagcatggg  ttttgacat  agaagggtt  gaattgggt  gtctctacc  2580
cagaatggc  atttggagt  cagcttcaa  ttctgccct  tccacagat  ccaggcaat  2640
ctgaagcag  gataatcag  agtactaaa  tttcagaag  ggagttctg  caccccatt  2700
ctccatcga  aggtctttg  agttgtggt  gtgaggcca  aggaactta  gaagaatga  2760
ctcaacatt  cattccatc  aaggttgca  aatactttg  gtatggaga  gaccgatcc  2820
tttaacctt  ccctttgac  atactgcat  ccctgtgag  ggctgctct  agctttggc  2880
ggggatgag  agggtgaag  tgaaaatgt  ctctgatgt  ggtttttct  agtgtctct  2940
ctctcccac  tttctagtc  attggaagt  ctccagatc  tctagattt  tgacctctt  3000
ttacattct  agaggtgtc  tttacctgt  ggtgagggg  ttggagggc  tgactatta  3060
gcttcctat  atgattggg  aaggggact  aacatcttc  ccttgtctg  tcctgggaa  3120
tcaagactg  tgtccatcc  ttattagta  cctagtttt  ttgagagag  ggtgcagca  3180
ttccctcaa  tacctgcat  ctcataggt  tgcatgctt  taggtatgc  tgcacacca  3240
caccttgac  tccaccagg  cagtgaatc  gtagtcccc  ttaatgata  tctcagaat  3300
gtctccacc  atgtgcaca  cttcatgca  acaattgta  tcctcttta  gagagacag  3360
gaccatgcc  ggctcttca  atacacact  ctgtatttt  atttctgaa  tccctgaag  3420
ttcacccac  tctccatgg  actgaatca  ttttctgcc  aggctggag  tagaagaac  3480
atgggttga  ggccttggg  gaagaggtg  taaggagct  cctggttct  tggactcct  3540
agaaacctc  cgtgaagac  atatatatg  gcaatatat  agcaattaa  atagaacta  3600
gtcattgaa  gactcagaa  gaaactggc  aggggctaa  tagctgtga  ctgctcttc  3660
tgttaactg  cctcaggag  gaaaagttg  cttgattta  tccagagac  cctgagaat  3720
ttgttactg  agctatagg  actaggact  cctcctcag  ctcatcagg  aatctggga  3780
aatctcatc  ccatgctgc  gtctccccg  ttggcacca  ctagggctc  gaagatctt  3840
aaagtgagc  ttaaatgaa  caggccttc  ggggcatcg  gatggagct  ctgaggact  3900
ggagggccg  tttcttcat  attcctacc  agtttaggg  atgagaaaa  gccctgtgg  3960
tcttaagtc  cctgactat  tccactagt  tggccttga  tttgagaca  ctggtagat  4020
tacctggct  ccctaccaa  agatttgat  tgtttcttc  cgtggtttc  ggtgataga  4080
cccaaaggt  gctttttaa  tggagaatt  aataatcag  atatgtaag  gcactagaa  4140
cctgtgttg  aaactgcca  gtgtgggta  aagaaaagg  cgagagatc  ccacctcct  4200
ttaccctac  ccacaccca  aaaccagac  tgtctccca  gaagcaggt  tccctggac  4260
cagaggatg  cagggctct  caatctgtg  aattattat  attattatt  ttttgtatt  4320
atggggccc  agaaagggg  caggagagg  tacacccca  ctggggaga  caaagcaga  4380
ggatccagt  ttctgtgtg  tcttacctc  gtacttcct  gtagctctg  tgacaaagc  4440
agcaggcct  ccgtgtcca  gaccccatt  ctcccactt  tgtacacct  ggctggcaa  4500
tcttggagc  tctgggctc  gaaaactag  caatgatca  taaacctgg  ttgagtctc  4560
gttctggc  4568



<210> 5467
<211> 327
<212> DNA
<213> Rattus norvegicus
<308> AA891631
<400> 5467

gccagagca  agactcaag  caggtttaa  ggtcattgt  tagttccag  gcccgtggg  60
tccgaggtt  gccagcctg  tgtacacag  gggaggaag  gtcctagac  cagaaagag  120
gaattacaa  gcaaagaca  atacacacc  ggaaatcgg  tttgttctc  ccagacagg  180
ctacccttc  tggcctcct  caggggccc  atagataca  caaagaaaa  gatcacaga  240
aattacaca  actgtagag  cctgtcaca  cctgtctcc  gaggaacct  cttctcctt  300
ctgggagat  gtttatgag  atagatg  327



<210> 5468
<211> 4568
<212> DNA
<213> Homo sapiens
<308> AB032989
<400> 5468

cccattcct  gcccagtta  acagcacta  tggacctca  tcacaacaa  ctgagccgc  60
tgcgggccg  gtggacccc  acgcgcctg  cccaactgc  ctccctgct  ctgagccac  120
accacctga  cttcatctc  tctgaggcc  tttccccgg  acccaacct  cgctacctg  180
acctctcct  caaccagct  cgtacactg  atgagttcc  gttcagtga  ctgcaagta  240
tggaggtgc  gctgctcta  aataaccac  tcatggcgg  ggaccggtg  gccttcgat  300
acatggccc  gctgcagaa  ctctacttg  gccagaacc  gatctctcg  ttccctctg  360
aactggtca  ggaaggagc  aagctaccc  aactaacgc  cctggatct  tcttctaac  420
agctgaaga  cttgccatt  cctgacctg  agaagctgc  ggcctggat  aagaatggg  480
tgtacctac  taacaaccc  ctgaactgc  actgtgagc  ctaccagct  ttttcacac  540
ggcagtatc  gcagctgag  tccgtgatg  actttcaag  ggatctgta  tgcatgaac  600
ccaagaagc  gcacaatgt  ttcaacctg  gtttcctca  ctgtggcga  tacaaggag  660
gtgcctggg  ggcccacct  ggtgacacc  tgatcatca  gtgtgacac  aagcagcaa  720
ggatgacca  ggtgtgggt  acaccaagt  atgaacggg  gctagatga  gtgaccaat  780
gcacagtga  tgtgtctaa  gatggcagt  ttcttttcc  gcaggtgca  gtcgaggac  840
gtggtgtgt  tacctgcta  gccatggga  agactttca  tgagacact  tctgtggaa  900
tgaaagtgc  caatttcac  ttgcacgga  accatgaca  cctcaacac  gcctatacc  960
ccctagtgg  ctgtatcct  agtgtggtc  tggtcctca  atacctata  ctcacccct  1020
gccgctgct  gtgccgggg  gtagagaag  cttccagcc  tcaaggaga  agcctcagc  1080
cttccatgc  tagtaccac  cccaaccat  atcctatgg  tggtgggga  aaagatgat  1140
gttttgacc  gcgggtggc  ttcctggaa  ctgctggac  tgggcaggg  caaaacggc  1200
agctcaagc  aggcaacac  ctgccagtg  ctgaggcca  aggcaaggg  caacggagg  1260
tgtcggatc  agaatcagt  agctcggtc  tctctgata  gcccattgt  gtgtgagca  1320
gatgggttg  tggggagat  ctgccccag  agaggtaat  cacccctga  ggatatgag  1380
ggatggaag  gagggctgg  tgcccaagg  aatggattc  tcctgacct  aagggaatt  1440
gtcccaggt  caacagaga  caagacccc  aacagggcg  ggctgccac  attttcaaa  1500
gggggtata  taatcctca  gcaaatgct  cacccgtac  caaagccct  ccaattctc  1560
gtgtggtag  ggaagagaa  catgtctga  ttggatggg  atgaggaag  agtgagggg  1620
agaacagat  ccctaaact  tcatgaggt  atccctagc  ccttaagag  aaaacattt  1680
gaaaaaaaa  ttttttcta  ctctgccca  ccacacctg  gatgttgtg  gtgttgggg  1740
agcttccac  ggagccaca  tggggaaaa  ctgtagtat  ttctttgtt  agcaagtca  1800
acttcacag  tggggaagt  gaaaacctt  ggaaaatga  tcaggaaaa  gctgagacc  1860
caatcggta  caattcccc  aagctgttg  aagactttg  attaaagcc  ttctttttc  1920
tgatgtgcc  tgggtggat  gatctttgc  ggagcctgg  ctgctgcct  ttagttaca  1980
cagcaatgt  ggatgtggt  tctgtgcct  gtcctggga  caatggcac  gagggttat  2040
gcatgaact  aagggtcca  gtcacagca  aggtgccag  acgaaactt  tagatgggg  2100
gtgaattcc  gataggcta  ttccctggt  ggtgaaacc  ttggttagt  tttgattcc  2160
agcatctgt  tgtcaggcc  gagtggggg  tgctgaagg  agagctttt  tggatgcct  2220
ccacagacg  ggtacatgg  cccacttca  gatagaagg  tgaaggtaa  tcagcctct  2280
ttatgtagc  tccagctgg  cctagctga  tctcaatgt  tgccatctc  tcatccagt  2340
tccttatca  gctcaggtg  gattctgaa  tttccctaa  atgctgctc  gtaaaggga  2400
gagtccaag  aagcctggc  ccagctggc  tagagtagg  ttggcgata  tgaaaatcc  2460
gtatatatc  cctctgtgt  gacaaggtt  ccttgctcc  ctcagagat  ccacctctg  2520
tgcaaagtc  aagcatggg  ttttgacat  agaagggtt  gaattgggt  gtctctacc  2580
cagaatggc  atttggagt  cagcttcaa  ttctgccct  tccacagat  ccaggcaat  2640
ctgaagcag  gataatcag  agtactaaa  tttcagaag  ggagttctg  caccccatt  2700
ctccatcga  aggtctttg  agttgtggt  gtgaggcca  aggaactta  gaagaatga  2760
ctcaacatt  cattccatc  aaggttgca  aatactttg  gtatggaga  gaccgatcc  2820
tttaacctt  ccctttgac  atactgcat  ccctgtgag  ggctgctct  agctttggc  2880
ggggatgag  agggtgaag  tgaaaatgt  ctctgatgt  ggtttttct  agtgtctct  2940
ctctcccac  tttctagtc  attggaagt  ctccagatc  tctagattt  tgacctctt  3000
ttacattct  agaggtgtc  tttacctgt  ggtgagggg  ttggagggc  tgactatta  3060
gcttcctat  atgattggg  aaggggact  aacatcttc  ccttgtctg  tcctgggaa  3120
tcaagactg  tgtccatcc  ttattagta  cctagtttt  ttgagagag  ggtgcagca  3180
ttccctcaa  tacctgcat  ctcataggt  tgcatgctt  taggtatgc  tgcacacca  3240
caccttgac  tccaccagg  cagtgaatc  gtagtcccc  ttaatgata  tctcagaat  3300
gtctccacc  atgtgcaca  cttcatgca  acaattgta  tcctcttta  gagagacag  3360
gaccatgcc  ggctcttca  atacacact  ctgtatttt  atttctgaa  tccctgaag  3420
ttcacccac  tctccatgg  actgaatca  ttttctgcc  aggctggag  tagaagaac  3480
atgggttga  ggccttggg  gaagaggtg  taaggagct  cctggttct  tggactcct  3540
agaaacctc  cgtgaagac  atatatatg  gcaatatat  agcaattaa  atagaacta  3600
gtcattgaa  gactcagaa  gaaactggc  aggggctaa  tagctgtga  ctgctcttc  3660
tgttaactg  cctcaggag  gaaaagttg  cttgattta  tccagagac  cctgagaat  3720
ttgttactg  agctatagg  actaggact  cctcctcag  ctcatcagg  aatctggga  3780
aatctcatc  ccatgctgc  gtctccccg  ttggcacca  ctagggctc  gaagatctt  3840
aaagtgagc  ttaaatgaa  caggccttc  ggggcatcg  gatggagct  ctgaggact  3900
ggagggccg  tttcttcat  attcctacc  agtttaggg  atgagaaaa  gccctgtgg  3960
tcttaagtc  cctgactat  tccactagt  tggccttga  tttgagaca  ctggtagat  4020
tacctggct  ccctaccaa  agatttgat  tgtttcttc  cgtggtttc  ggtgataga  4080
cccaaaggt  gctttttaa  tggagaatt  aataatcag  atatgtaag  gcactagaa  4140
cctgtgttg  aaactgcca  gtgtgggta  aagaaaagg  cgagagatc  ccacctcct  4200
ttaccctac  ccacaccca  aaaccagac  tgtctccca  gaagcaggt  tccctggac  4260
cagaggatg  cagggctct  caatctgtg  aattattat  attattatt  ttttgtatt  4320
atggggccc  agaaagggg  caggagagg  tacacccca  ctggggaga  caaagcaga  4380
ggatccagt  ttctgtgtg  tcttacctc  gtacttcct  gtagctctg  tgacaaagc  4440
agcaggcct  ccgtgtcca  gaccccatt  ctcccactt  tgtacacct  ggctggcaa  4500
tcttggagc  tctgggctc  gaaaactag  caatgatca  taaacctgg  ttgagtctc  4560
gttctggc  4568



<210> 5469
<211> 384
<212> DNA
<213> Rattus norvegicus
<308> AA891634
<400> 5469

aagagttga  agtttgaga  cactctttt  ttcaccaga  tacatcaat  gtatccaga  60
gcaggtagt  aatatatac  gtttgtatc  ttatcaaaa  agcaagtca  atgaatgaa  120
aaaacaaca  tgaataaat  gcaaaactt  aaatgaata  aaggaaaac  aaataacca  180
agtaatcag  agtcaaacc  aaatgtaaa  agaggaatt  tcctaagca  tcttttgat  240
ctcgtttgc  gaattgact  atagccaat  acttgcctt  gaaacacag  agacaagca  300
ttactgatg  taataatct  ttcaagggg  atgtaagta  gtctgcctt  ttggagtga  360
ggtatgaag  acaaagcca  ccaa  384



<210> 5470
<211> 499
<212> DNA
<213> Rattus norvegicus
<308> AA891651
<400> 5470

aaagggcaa  acactcaga  aatttaaat  caagtcgaa  agaaccgct  tcagttggc  60
acgatgcca  catgtgtcc  ctggagtcc  cacagtgag  aagaaggct  tggcaatga  120
aagagaagt  ggtttcttg  tgtgcagtc  ctgattcta  gtgccatct  caaggtgcc  180
aatgctctg  aactaagta  ctcaagcac  aaaacacaa  agctgaacc  gcaatgatt  240
tcagctaaa  cttaacagt  ggcagcact  accatctgt  agccaattt  accttcaca  300
agtcatgat  gggccaacg  cattcccac  ttatgtggg  tcagattca  cagctcatc  360
aagatgacc  ggctcacag  atacctgac  atgaagcca  cttgggcct  tctctaaag  420
ccatcctct  agttgtgag  aatcctggg  cacctgagc  ggtgaggct  acgctgggt  480
ggtgcctac  actgaggtt  499



<210> 5471
<211> 663
<212> DNA
<213> Homo sapiens
<308> NM_005003
<400> 5471

agtgcatcc  gggttggcg  agccatggc  tctcgtgtc  tttcagcct  tgtcagccg  60
ctgcccgcg  cctttgcgc  gctgccccg  gtccggatg  tggccgtgg  ccggcctct  120
agcactgct  tctgctccg  ggggaccca  acgaggctc  ggactttgc  gccggcctt  180
gtgctcgcg  aggttcctg  tagagttac  cagttgtgc  gccagtata  cgacatgcc  240
cctttgacg  tagagggca  ccaggaccg  gttctttac  tattgaaac  ctatgacaa  300
attgaccca  agaagcttt  agtaaattc  cattttatg  aagacctgg  cttagacag  360
ttggaccaa  tggagatta  catggccat  gaagacgaa  ttgggtttg  aattcctga  420
atagatgct  aaaagttaa  gtgtccaca  gaaattgta  attacattg  agataagaa  480
gatgtatat  aataaagta  cagaccctt  ggctttgct  agagaggac  cagatgata  540
tgacgaatg  ctggcagtg  ggacacatt  tggcattct  gctgactct  acagagtga  600
tctgatgga  ttgtattta  attgtatgt  ttttactct  tgaaaataa  tctataaaa  660
caa  663



<210> 5472
<211> 156
<212> PRT
<213> Homo sapiens
<308> O14561
<400> 5472

Met Ala Ser Arg Val Leu Ser Ala Tyr Val Ser Arg Leu Pro Ala Ala 
  1               5                  10                  15
Phe Ala Pro Leu Pro Arg Val Arg Met Leu Ala Val Ala Arg Pro Leu 
             20                  25                  30
Ser Thr Ala Leu Cys Ser Ala Gly Thr Gln Thr Arg Leu Gly Thr Leu 
         35                  40                  45
Gln Pro Ala Leu Val Leu Ala Gln Val Pro Gly Arg Val Thr Gln Leu 
     50                  55                  60
Cys Arg Gln Tyr Ser Asp Met Pro Pro Leu Thr Leu Glu Gly Ile Gln 
 65                  70                  75                  80
Asp Arg Val Leu Tyr Val Leu Lys Leu Tyr Asp Lys Ile Asp Pro Glu 
                 85                  90                  95
Lys Leu Ser Val Asn Ser His Phe Met Lys Asp Leu Gly Leu Asp Ser 
             100                105                110
Leu Asp Gln Val Glu Ile Ile Met Ala Met Glu Asp Glu Phe Gly Phe 
         115                120                125
Glu Ile Pro Asp Ile Asp Ala Glu Lys Leu Met Cys Pro Gln Glu Ile 
     130                135                140
Val Asp Tyr Ile Ala Asp Lys Lys Asp Val Tyr Glu 
 145                150                155



<210> 5473
<211> 518
<212> DNA
<213> Rattus norvegicus
<308> AA891664
<400> 5473

cggccgcca  acttttttt  ttttttttt  ttttttttt  gccttaaat  aaagtttaa  60
ttcttacag  tcaggtgtt  gggagagca  ctttagatt  tctcggcct  tctttcatg  120
tgccaaagt  gcttcccca  atccagcca  cacacccac  ttcacagta  gaaggcagg  180
tcttgggct  ggagtgtac  ccagaaacc  ctctattga  tttgctcag  tctgctggg  240
catatggcc  ctcctcaca  caaaagagg  tgggacact  aaccaaagg  ccattgcga  300
tggcacctg  gcctgctgg  gttccgaag  ctaggtcca  tggccagct  tgcagaacc  360
ggagcggct  aggccagcc  catagctgc  gatcacaga  ctggtttta  cccaatgac  420
ctagtccct  aagaatgac  gaggccaga  ccagaggcc  gactccagg  agggcacat  480
tcaccctca  gagggtgag  accccaacc  cctcctac  518



<210> 5474
<211> 321
<212> PRT
<213> Rattus norvegicus
<308> NP_032621
<400> 5474

Met His Cys Arg Leu Phe Arg Gly Met Ala Gly Ala Leu Phe Thr Leu 
  1               5                  10                  15
Leu Cys Val Gly Leu Leu Ser Leu Arg Tyr His Ser Ser Leu Ser Gln 
             20                  25                  30
Arg Met Ile Gln Gly Ala Leu Arg Leu Asn Gln Arg Asn Pro Gly Pro 
         35                  40                  45
Leu Glu Leu Gln Leu Gly Asp Ile Phe Ile Ala Val Lys Thr Thr Trp 
     50                  55                  60
Ala Phe His Arg Ser Arg Leu Asp Leu Leu Leu Asp Thr Trp Val Ser 
 65                  70                  75                  80
Arg Ile Arg Gln Gln Thr Phe Ile Phe Thr Asp Ser Pro Asp Glu Arg 
                 85                  90                  95
Leu Gln Glu Arg Leu Gly Pro His Leu Val Val Thr Asn Cys Ser Ala 
             100                105                110
Glu His Ser His Pro Ala Leu Ser Cys Lys Met Ala Ala Glu Phe Asp 
         115                120                125
Ala Phe Leu Val Ser Gly Leu Arg Trp Phe Cys His Val Asp Asp Asp 
     130                135                140
Asn Tyr Val Asn Pro Lys Ala Leu Leu Gln Leu Leu Lys Thr Phe Pro 
 145                150                155                160
Gln Asp Arg Asp Val Tyr Val Gly Lys Pro Ser Leu Asn Arg Pro Ile 
                 165                170                175
His Ala Ser Glu Leu Gln Ser Lys Asn Arg Thr Lys Leu Val Arg Phe 
             180                185                190
Trp Phe Ala Thr Gly Gly Ala Gly Phe Cys Ile Asn Arg Gln Leu Ala 
         195                200                205
Leu Lys Met Val Pro Trp Ala Ser Gly Ser His Phe Val Asp Thr Ser 
     210                215                220
Ala Leu Ile Arg Leu Pro Asp Asp Cys Thr Val Gly Tyr Ile Ile Glu 
 225                230                235                240
Cys Lys Leu Gly Gly Arg Leu Gln Pro Ser Pro Leu Phe His Ser His 
                 245                250                255
Leu Glu Thr Leu Gln Leu Leu Gly Ala Ala Gln Leu Pro Glu Gln Val 
             260                265                270
Thr Leu Ser Tyr Gly Val Phe Glu Gly Lys Leu Asn Val Ile Lys Leu 
         275                280                285
Pro Gly Pro Phe Ser His Glu Glu Asp Pro Ser Arg Phe Arg Ser Leu 
     290                295                300
His Cys Leu Leu Tyr Pro Asp Thr Pro Trp Cys Pro Leu Leu Ala Ala 
 305                310                315                320
Pro 
                 325



<210> 5475
<211> 31737
<212> DNA
<213> Homo sapiens
<308> Z93096
<400> 5475

aagctttga  gtccagata  aactcagcc  agtggaggg  atgtgggtg  ggctggtgg  60
atatgggag  gcatcccgg  ggaaacctg  gagcaaaag  tgggggctg  gtgaagcag  120
acaccaaag  aatgggtgt  gaatgggcc  agctgacag  tctctgggg  agtggacgg  180
gctggagga  actcccttc  accgggcac  gagggtttg  tgtgacttc  tcccaccgc  240
gcagctggc  gagccgggg  tgccctttc  gctggtgcc  cctttcagc  gcctctgtc  300
ggggttccc  tcgtctggc  ccgcccctc  ggctaagcg  ggcggggcc  ggcggtccc  360
gaggctgcg  caggccgga  agcgggagc  ggtggagga  tggcggcgg  cgagatcgt  420
ctgccatgg  tcagcctct  ggtccagag  ctcagctcc  acctcttcc  tccttgcca  480
cccctgatg  ctgccagac  tttgcctct  ctggagccc  tgcctgacc  gcttcccct  540
cctgtctgg  tgggatttg  gggctgagc  gtctggggt  ccagggcca  ccaatgcag  600
gccggctcc  gcggggcct  gctggagcc  tcctcaccc  cctgtgcat  gggctcctg  660
gtctgcggt  ccacttgaa  ctgtccccg  agcgggtac  agggacccc  gagctgagc  720
agccgaacc  ggggccccc  aagctacag  tacacgatg  cttcattgc  gtgaagacg  780
cccgggctt  ccaccgctt  cgcctggag  tgctgcttg  cacgtgggt  tccaggacc  840
gggaacagg  gacaagtgg  tgacattgg  ccctggggg  ggcccctgg  ctaaggggt  900
ctcagaggc  tttctactg  gctggggtc  ctgactgcc  catgggaga  gctgctcaa  960
acctgccta  tcagggatc  tcttcctct  tccttcttc  gggctttag  ggctgcctg  1020
ggccctgcc  gtgccctgt  ctggtcctg  ctccaggtg  acccaggtc  taccgctcc  1080
ccacttttg  gggccaggc  gggcccctg  tccaggctc  cgggtccct  ctgggggtt  1140
ttctattcc  agccgctcc  gtgggggct  cgctcctag  cacccaggc  cagcctggc  1200
tcaggggta  tggtgggtg  tgggcagct  gggtggagg  ctccaagag  tcctgaccc  1260
gacccgtgc  caggccagg  tgtcccacc  aggccctag  tgctgtcct  cccgggctc  1320
gagggtgga  gacgggagg  gaatggtgg  gtctgttct  gggggaggc  tcccttcgg  1380
cttcccgat  gcccctgcc  ctgtgtctc  gctgccccg  gtgtgccga  gccgccatg  1440
ctggcctcc  gtgttggct  cctgcggac  gcttccgag  gagggaagg  gagcgcatg  1500
cacgagggt  gcggctgag  cagtggtgg  ccggaggtt  gggaggcct  cctggcacg  1560
gggattgtg  gtgtgtgtg  gtgtgtgct  acacgcacg  agctggagt  tgctagatg  1620
gtgtgacaa  aggcatgtc  gtcacatgg  tgtgcggct  cggcgagcc  agtcccttc  1680
agccctttc  ctcctcgca  ccagtatct  ccttaagca  agttagtga  gtcggtgtt  1740
gggaccgtt  atgggggag  tggagaatg  gtacacaca  acacacaca  acacacaca  1800
cggtcccct  tttggcggc  ggctcagtg  gaggaagtg  ctgagtctt  ggagatagt  1860
gagacctcc  ggaagacca  aaggagggg  agaggatgg  tggcagagg  caggccctc  1920
tggggaggg  caccctgcc  tgatttctg  cctcgtact  gggattaac  cttccccag  1980
tggccccca  cacctcagc  cttctctgg  ccccacacg  cttctcatc  tggggagat  2040
ctggttctt  ctgcggaag  agccaaggc  ggccctccc  caggccttc  tgtttatgc  2100
tctgtgtac  cgggagcgt  gcctcacgt  gcccacggc  ctttcctgt  ttatctcca  2160
caccgcggt  gtgcccttg  cccggatga  gaaactgag  ccagagaga  gaagtgctg  2220
ctggcgtgg  gtcacgcag  aggcctgag  ggacagagc  cagtgggac  tagaacctt  2280
ctcctggtt  ggtgctttt  tcccctgct  agacttggg  accctgtga  gactgggtc  2340
ctgggctac  ggagtcgct  ccccacgtc  ctcaccctt  ggctcactt  tctctgtga  2400
ctcagccaa  gccctcccc  ttcggcccg  agtttcccc  tctgcacgg  gcaggagtg  2460
ctggaccgg  cctgagctg  ttaactgca  cgctgggcg  ccgcctggc  ggttaaggg  2520
ggtcgggtg  caggtgggc  ttgcggcag  ggccgggac  cgtgtgccg  cctttgtcc  2580
gggctgagg  ggtgggctg  gggaggcgg  ttttgtgct  aaggcgagc  tttctcctc  2640
ctatggtcc  cttgttggg  ggagaggtg  cagcagccc  accactccc  tcctctgca  2700
cagatggtc  ccggccacc  ctcccctgc  ccagcaggc  gcgtgtccc  ttgtttccc  2760
cggctgcct  tgaagtttt  accattgtc  ggtcccctc  ttaaacaag  caaatgcag  2820
ccttggctc  aaagaaact  tgcccatcg  tctgtgcca  ccttaggat  cccagggac  2880
gaaagcgcc  gcctcactg  cctctcctg  gcccccgcc  cctctggac  tggactccc  2940
ttcccggct  tctccctca  tctgttcat  gctgctggt  ttttgtttt  tttattttg  3000
gacagagtc  cactctgtt  tccaggctg  agtgcagtg  cacgatcct  gctcactgc  3060
acctccgcc  cctggtttc  agtgatcct  agcttcctg  gtagcttgg  ctacaggca  3120
gcgcaccac  cccggctaa  ttttctatt  ttagtagag  tggggtttt  ccatgttgg  3180
caggctggt  ttgaactcc  ggcctcaaa  gatccacct  ccttggcct  ccaaagtgc  3240
tattctcct  ctttattca  gcttactag  tcttcaccg  gaaacagtc  tcagcccat  3300
tggcccatg  tccaagctt  agagtgttt  actatcggg  ggctgtttg  tggcaaaag  3360
ttgtcgagg  cagggtagg  aaggcctgg  ttctttgat  ggatccctt  aggctgtgt  3420
gaaaaccga  ttggggtgg  ggcagggag  agggaggcc  gggaggagg  cctgcagca  3480
agcaggcag  aggtgacga  agtggcggg  actaggtgg  cgggtgggc  ggagggaag  3540
gcagcgtcc  agacgattt  gaggctggt  agcagaatt  atgacaggc  cgggaagag  3600
tgtgagagg  agagaggag  agcggggag  ctgaggttt  gggtcccaa  cagtgagag  3660
gaggagcag  tcttgggga  aacgggggc  cagtcttga  gtgttaagc  cccaggaga  3720
gtcatggtt  caggggatt  gacagtttg  agctcaggg  gaggctagg  ctggtggtg  3780
ccacgagtc  ccagctccc  gatggtgtt  aaagctgag  ggctgcatg  cgtcactga  3840
ggagtgggc  tcatggaga  gcggaccag  gtctaggct  ggaccacca  catttcccc  3900
tgcggaaat  cagagacct  cagcattcg  taaatctga  ggtgggaga  agaccccag  3960
gagagaggc  cagagggtg  atgctgcac  ggccttcct  aggagagcc  ggtgccgga  4020
caaggagac  aattggacc  agcctgtgg  ctccaggat  ccatcgtct  gtggaagag  4080
cggggagag  aatttctgt  accagggag  tttgctaac  gctgttagt  acaggagaa  4140
cagagggct  aggaacaca  agcaggggc  tctaaagta  ctggagggg  gtcagggaa  4200
gcttcctgg  gaaggtgat  cctgagctg  gagctagag  gtggaaaga  ggcatagca  4260
gcgcagagg  tcagaggcg  gcgcacgtg  gtgtgtgtg  gtgtgtgtg  atgcgtgcg  4320
gtgtgtgcg  gtgtgtgtg  gagagagag  gacagagag  gaagcccca  gggtggaca  4380
gaagtaatg  gatcagact  catcaggca  ggtggccag  tggcccctc  ctggccaca  4440
ttagggagg  tggccttta  cccaagagt  gtagggagc  atggaaggt  ttagtggct  4500
gtgggtgga  ttgggtgtt  ctcgattct  gtcctggca  ggaaacata  ctgagggaa  4560
gaggcagag  cttgcagta  tccagtgag  ggtgatagt  gctcagaag  agggctgtg  4620
ccatgggcc  taggagata  cctggctcc  tcctgcccc  tcctgtgtc  aacctggct  4680
ccggcctcc  ggcctccta  gcctcagtt  cccctgaaa  acaagtagt  gagcctgac  4740
tcactgtca  ctcttcctt  ctcttttac  cacaatctt  ttttattct  acagccact  4800
ctatccccc  tttgtagat  ggtaaactg  ggatcaagg  ggggactct  ctgatctga  4860
gggctaatt  ctggaaagg  gggagggga  tttaggtaa  cagagggga  cattgcagt  4920
ggaggcgct  agcttcaag  gaggacagg  ttaagccac  agtgtggcc  cagtggggg  4980
tgagagagt  ggagggctt  aaagaggtg  gacacttgg  aggggtccg  aattgtcct  5040
agtcctggg  cgggcagtc  cagggccgg  gaggccctc  aaggcccct  atgctcaat  5100
ggtgagagg  cccacttgg  cagctgaga  gctctgcca  gttgggccg  gcatggaat  5160
ggaagaaca  cagtcccca  cctggcttg  ctttgtccc  agcctggct  gtctttgtc  5220
catccatgt  cttcctcta  ctctcattc  gagtctgag  ttggattat  taggggctg  5280
gcagcttta  ctgcctggg  ggcggtggg  agaggtccg  ggcctatgg  tttgaatct  5340
agcctggca  ttgccaatc  tggtccatc  ctcagcctc  tttttgtca  ctggaaagg  5400
aacagatga  aacgcctgc  tcgtgaggt  tgagggtcg  tgcgggcaa  tgcatgtcc  5460
atctgggag  gccggactg  gttgtgagg  agcatttcc  agatggctt  cacaggggg  5520
ttgtgtggc  gtgaaggtg  gacgtctcc  tagtggcgt  gtgtcccat  gtgtggccg  5580
gggtctgtt  acatagagt  tgtgtcctg  aaatgggtt  aagattgtg  tctgtgatt  5640
tggaggagc  gagtgcagc  gtgattgtg  gtgtgtgtg  gattgtgtg  gtgtgtgat  5700
gaagagggt  agatgctgc  caggtgtgt  gctgtggtt  ggtccctgt  gtgctgctc  5760
ggaaagggg  tgagtgtat  tgtttagac  gtgggctgt  tacaccctg  agttgtgtg  5820
ctacaaaag  tgggttgtg  gtgttgtat  ttgtcctaa  ggagcgtgt  accatgaga  5880
gggtgtgtc  gtcactgga  gagtacaga  tccatctgg  gcctggtgg  ggtgggctg  5940
ggattggtc  ggggtgtcc  ttgggccga  gtgagtcct  accccttct  ctccttcct  6000
gacatttgt  ttcaccgac  gcccagaca  aggcctcca  gagagactg  gtaactctg  6060
ccggcctgg  tgtggtggg  gactttagc  gttgcctgg  aaagctggg  cggctgtgc  6120
ctggcctga  ggttcccag  aaatgggcc  cccaccctt  gcatgtgga  attcccctt  6180
gcccaggag  gaagtgggc  tcttccctg  aaactggtg  gggcgtggg  atggggaag  6240
gcggtgctg  acaaggccc  ggacacctg  gtcccagcc  agcctgctg  ccactaggt  6300
tgtggtcct  ggcaggtct  ccttccccg  gtctcagtc  taccatgtg  aaaatggga  6360
tgggtgggc  gctccagac  ccctgttgc  cagccttgc  ctgtattct  tgttcaggg  6420
tctgaaggg  ggacctggg  agggtcccc  gactcctcc  cacttctcc  gggtcccac  6480
ttgtggtca  caactgctc  gcggaacac  gccacccag  tctgtcctg  aagatggct  6540
ctgagttcg  caccttctt  gccagtggg  ttaggcgag  gttcctggg  ctctgggga  6600
aagtgtggt  tgggcccag  gaaaataac  cctgggact  ctggggtct  acttcagcc  6660
ccactcctc  agcaggcag  gggcagatg  ctgggaagt  cagctgggt  ccagtcctg  6720
cattcagga  tgggtatgt  accttggga  aatggcttt  ttttttgag  cagagtatc  6780
ttcttcttg  ccaggctgg  gtgcaaatg  tgcagtctc  gctcattgc  acctccgct  6840
ctggattca  gcgattctc  tgcctcagc  tcccaagta  ctgggatga  agatgccca  6900
catcatgcc  ggctaactt  tgtaatttt  gtagagacg  ggtttcacc  tgttggcca  6960
gctggtctc  aactcctga  ctcaggtga  tcacctgcc  cggcctcct  aagtgctgg  7020
cttacaggc  tgagccacc  cacctggcc  gggcgagtg  cttaacctc  cagtcttgg  7080
cctcaactg  gaagtgggt  ccctcctca  gagcttaca  aatatgcaa  ttggcacaa  7140
acagatgcc  taaatgtca  cctctccca  ccctacccc  attccgtca  tgttgaccg  7200
ctgtggggg  gcttgggga  cctggcttg  aaccccccc  acaagttca  tgtccccgt  7260
tcatcccta  aggtggttc  gccatgtgg  cgatgacaa  tatgtgaac  caagggcgc  7320
gctgcagct  ctgagagcc  tcccgctgg  ccgcgacgt  tatgtggga  ggcccagcc  7380
gaaccggcc  atccatgcc  cagagccac  gccccacaa  cgcacggtg  gtccctctc  7440
tcctccttt  ccccttggc  cgctgatcc  aagggccgg  ccggtcctg  gggtggggg  7500
gtgctagag  ggtgagagg  gttctgggt  tcaggtttg  ccctatgtg  gtttgggct  7560
gtagcttcc  ctcttcaac  ctcagtctc  tcctctgtg  aatggggag  ctgagatca  7620
gcagtcgtg  cacagacac  gtacatagt  aggcctcca  cccccagga  ccacggctt  7680
tcctggtca  tcagggagc  tccaggtga  ctgaggctg  gtgacacca  agcagggct  7740
ccagtcacc  ggtgtcccc  tgtaggtgt  caggttgtt  aaatgctgg  atggctggg  7800
gcagtggct  atgcctgta  tcccagcac  ttgggaggc  gaggtgggt  ggtgacctg  7860
ggtcaagag  tcgagacca  cctgaccaa  atggtgaaa  cccgtctct  ctaaaaata  7920
aaaaattag  tgggcatgg  ggcgggcac  tgtagtccc  gctactcgg  aggctgaga  7980
aggagaatc  cttgaaccc  ggaggcgga  gttgcagtg  gctgagatt  tgccactgc  8040
ctccagcct  ggcggcaga  cgagactcc  tccctccgt  aaaaaaaaa  aaaaaaatt  8100
ctgaatact  tggggctgg  tgattgctg  cacctgagc  ccagaaccc  tccccacct  8160
cccctcctg  ggcaccctc  ccctccaga  acctccact  gcctgtgac  gaagagtcg  8220
cacctggca  aacaggggg  tctgtaccc  cctcagttc  tgacctgga  ggacactga  8280
ttgggttgc  agattcatt  aacaaataa  tgaaaaacc  ctacatcca  ttaaacttg  8340
ctttctcat  aataatgag  aaattttta  tataagtat  tcccaaata  tgcatggtt  8400
tctccctgt  cccaggacc  cctgggcat  aggtgttag  gtggtcctg  ccctagggc  8460
cccttggct  caggaagaa  gcagatcgg  aggtccctc  ctagaggca  tgcctggtg  8520
aggagctgg  cacacagcg  ggctcaacc  cccttccca  gtccccatc  gcttcatta  8580
gaaaaccaa  agcagaaaa  acagagcct  aattatcag  agctaatca  cctctgagc  8640
ttaattaaa  tcttctggg  cctagggct  tgtgtatga  tgattccag  ggagccagg  8700
ggtccccca  gctctcaca  cacttcact  ctggcgact  acctctgcc  aagcagttt  8760
cctctgggg  ggagaactg  acgctggag  ctgactccc  gggtttaca  ggcagccct  8820
ccacctcct  gctttgtga  cttgactga  gtcacctca  ctctctgtg  ctcagtttc  8880
taatctgtg  aatgggtga  aacagcccc  actcaaaga  tggtcgtga  cacagaaga  8940
agaatgaaa  gaggtcatc  ctccaagtc  ttggaatga  acctggcac  aagtcaaca  9000
tagaaagtg  tagtgatct  aggccgggc  cggtggctc  tatctgtaa  cccagcact  9060
tgggaggcc  aggcaggtg  atcacctga  gtcaggagt  tgagaccag  ctggccaac  9120
aatagttaa  ccctgtctc  actaaaaaa  acaaaaatt  gttgggcgt  gtggcgcac  9180
tctgtagtt  cagctattt  ggaagctga  gctggagaa  cgcttgaac  tgggaggcg  9240
aggttgcag  gagcagaga  ggtgccact  cacttgagc  tgggcaaca  agcaagact  9300
tgtctctta  aaaaaaaaa  gtgttagtg  tttgtattg  acacagcct  acctttgtt  9360
cccagccac  tctttccta  gcacactca  gccccgtca  cctaggccc  cctctgtgg  9420
ccaggagag  aggtgccat  ttcggcagc  cctcccaag  cacatggag  gaggtagag  9480
cctttctca  gggaaaggg  catggtggc  gggtgggta  aacaacacc  gtccccttt  9540
actggaatt  agctggact  gagtctgat  agtgacctc  ccactcata  ttaactatg  9600
gacttcggg  ctctgtttt  ttatctata  aatgggtgc  ataatgcca  gttgtagca  9660
gactctagt  agattcaaa  taaagggct  ttgagccat  ctggttggg  gtgaagggt  9720
gcctggctg  cccttttcc  cacaactgc  accaggctc  ctctgcccc  tggccttcc  9780
ctctctcag  ggctggtac  gttctggtt  gccactggg  gtgctggct  ctgcatcaa  9840
cgcaaactg  ctttgaaga  ggctccgtg  gccaggtaa  cagagaccc  ggggtgggc  9900
ggaaggcgg  gagggggtg  cagctgggg  acaggaggg  cctttgcag  aggaagggc  9960
ttgagagtg  gctcaggag  agctgctcc  catttgcgt  tgtcacaga  cggcagttg  10020
tggtgaaca  gccacctgc  acctgccct  aggggctgc  cggctgagc  catgacgtg  10080
cactcacag  caagtcatg  catctccaa  agccccagt  cccccgtcg  cacatggac  10140
tgataatgc  gtggccaat  gtgtagtaa  ggttaaatg  gaaaatgtc  gggctggcc  10200
tggtaggtg  tatttaccg  ccttttctg  ctggtcaat  ccgtagggg  ggtgaaggc  10260
aaatctaag  gtcttcaga  gagggagaa  ggccttctg  gtgagggaa  aagggaagg  10320
ttccaggaa  aggtggtat  tgagctggg  cagtccact  tacactggg  catctaagg  10380
agatgatat  actcctaat  gcacagtgg  tgtacatcc  gtgatatta  tcataatat  10440
atctaaggg  gatgatatt  ctcctaata  tatgagggg  tctcagggg  agtggaggc  10500
gcagtgtgg  tgggggtgg  acacaggtg  tctagaagt  gcgaggcct  gcttctgga  10560
gtctttccg  gctattatt  ttattaaca  caccatcag  agccactcc  ttgtattga  10620
gactgactc  gagccagct  tgtgctcca  caagaggat  acaacacct  ggggagaag  10680
tggcattag  cttgtttct  gatctcagg  aactgaggc  ctgagatta  gccagtctg  10740
ggtcagcca  gttcaaggt  actcagctg  tgggtttgg  tccaaggtc  gcaagcctt  10800
ctactaccc  agcctgccc  gccttgccc  ggctgggag  ggcgcccca  gcaattcat  10860
ctggacaag  gcgggctca  tgtcctggg  catgtccac  gaactgtgt  tgtacacat  10920
accagggtc  tccgtgtgc  tggggtgcc  ccacccagg  ttctgccca  ctctaaatt  10980
cctttgtgt  aattagaaa  agccctctc  ctccaactc  tgcaggtgc  gcttgaggg  11040
atgcaggct  gggagggga  tgcaggctg  ggaggggag  gcaggctgg  gaggggagt  11100
caggctgga  ttccacacc  acttgcccc  tggacaagc  tccagggca  cggcattaa  11160
ggggtatac  cggccagtt  aagtccatg  ctgggactc  gttcctgtc  cccctcagc  11220
ctggctgac  ccagcccat  ctgcaagac  ctgtttagg  ggctcatgc  tgtaatccc  11280
gcactttgg  aggctgagg  gggtgactc  cttgaggtt  ggagttcaa  accagcctg  11340
ccaacgtgg  gaaactctg  ctctactaa  aatacaaag  ttagccggg  atggcagcg  11400
gtgcctgta  tcccagcta  tcaggaggc  gagacagga  aattgctta  acccaggag  11460
cggagattg  agtgagccg  gattgcacc  ctgcactcc  gcctgggca  tgaagggag  11520
ctctgtctc  aaaacaaac  aacaaacaa  caaacaaat  aacacacaa  aaagctgcc  11580
cctcctctg  aaagcccgc  tgattctcc  tgtaccccc  ggcagcatg  ttccctctg  11640
cttagcacc  ctctttgaa  gacctgctc  ctgctctgt  tcccgccag  ataggggct  11700
ctgttgggg  caggaagcg  ttctttctc  tctctgtat  ctcagccct  gcatggtat  11760
tggcaccag  aatgaataa  tgagtgaat  aatgaatga  aagacagag  gagaaggaa  11820
ggctacatt  ataaagggc  tcaccttcc  attccctgt  taatcctca  gacagctcc  11880
cgaagacac  gccattagc  tccccattt  acagaacag  agactgagg  tgaggctcc  11940
caaggttcc  gacttgctc  aggtcatac  gtatgcagg  ggcaggtgc  ctgttctgc  12000
agcttgtcc  agtggaggg  cttcatggg  tggcccacg  ctctgggtg  ggagggcct  12060
ggccagcgt  tgcagtctg  ctctgtccc  cagtggctc  cgtttcatg  acacatctg  12120
tctcatccg  ctgcctgat  actgcacca  gggctatat  attgagtgc  agctgggcg  12180
ccgcctgca  cccagcccc  tctttcact  ccacctgga  accctgcag  tgctgagga  12240
tgcacagct  ccagaacag  tgagctggc  ttgggggca  gtggcaaat  ggaagggga  12300
ccaaaggaa  atggggtcc  cccaaccct  cctcctggc  tttgaaaga  acctggaac  12360
ccagattat  ggtcttggg  attccctat  gatggggaa  ctgaggcct  gggtggcaa  12420
ggacaccct  agggtacac  gggactcaa  cccttcacc  ctaaccctc  aggattagc  12480
tttgtgaag  tgaaattct  tgatctggt  ctcaaatgc  gggaaggac  tgaacaaat  12540
agatgaggt  gtcttcagg  tcccaccac  ctgctctcc  cccatacct  tactcagtc  12600
tccatcctc  ccacattcc  cccggggag  ccagctggc  cttctaatt  tacctgtta  12660
gagcccctt  cttcatcaa  actccccta  ccattgctc  gtgctgttc  tgccaaccc  12720
gaggttacc  ggatggaat  ggtctttgg  gggacgctc  gcattatgt  aggctgggg  12780
aggaggggg  ccccatccc  ccacctggc  ggtgataca  gtccaactg  ctctgcctc  12840
gagaggctg  cctctgaca  tgtagatgg  cctggctgg  agcgtcccc  ggatctcct  12900
cccaacagt  tgacagaaa  tcaacgtga  ctggctaac  tgaaaagga  attgttggc  12960
cacataact  agaagctct  ccccaagtt  gcccatcct  aggtgggct  agccctcat  13020
ttggcaaga  ggcagcccc  gctttcccc  cactatcgg  ggagagcgc  tccttcctt  13080
agatccccg  gctggcgtt  attgatttg  tgactgggc  tgggtcagg  gacccatct  13140
ctaccagca  ctggagtta  tgttgattg  ccaggcctg  aactggggt  tgaggttgg  13200
cccattagg  tggcagggc  tgaagccag  aaagagagg  agatttgag  cagcccaaa  13260
cagggcatc  taatggtta  ggtatcctg  gtacccaca  tgccaggca  cacactggg  13320
tccttccct  ctttttttt  ttgagatag  gtctcgctc  gttgcccag  ttggagtac  13380
atggcacga  tttggctct  tgcaacctc  acctcccgg  ttcaagtga  tctcctgcc  13440
cagcctcct  agtagctgg  actacaggc  cccaccacc  tgcctggct  tttttagta  13500
agacagggt  tcaccatgt  ggccaggct  gtctcgaac  cctgacctc  agtaatcca  13560
ctgcctcag  cttccaaag  gctgggatt  caggcatga  ccaccgcac  cagccaccc  13620
tctttaact  tctggttcc  cacagtagt  acatgaggt  agtactaac  ttatcccca  13680
tctatagat  gggaaaatg  gacccagcg  gctgaactg  ccacggcac  cagctaata  13740
ggggcagag  ggcactgga  ccctagctg  gtggtccct  tgcccacag  ctttaacca  13800
tgtgctcta  agcctctga  ctgaaatca  gatccatgt  gtcactgcc  ggtggagta  13860
gggctccgg  tgaagaggg  tgtgccaag  ccctccagt  agtctcaga  aacctccat  13920
ctagtccag  cttgcagct  actggaaag  tgccttttc  tgttgagcc  cagtttcca  13980
atctgtaga  gggggtatt  ttccagctt  tcaggggag  tcaactctt  agggagcaa  14040
tgggattaa  ggcatggca  tgctcttcc  gctgtgaag  gccttgggg  gtggggtgg  14100
ctcccacca  cagcgggga  tttcaggtt  ccgggcagc  ttccctgca  cttaaaacc  14160
ctcctccac  tgtgccagg  tgctgcccc  ttgtgggga  ccccagtgt  atgccccaa  14220
actcttcta  ctccctgcc  aggtcaccc  cagctacgg  gtctttgag  ggaaactca  14280
cgtcattaa  ctacagggc  ccttctccc  ggaggagga  ccctccagg  gggtctggg  14340
gctggaacc  tggatggga  gagtggggg  tgagtccag  catccaaac  tgggggagc  14400
gggagggag  ggagtggga  aggctttgg  ggctgacag  acagagcta  gagtggagg  14460
agtggattt  agtttctga  cctgccact  gcttgctgt  tgaccttgg  caagtgtct  14520
gccctctct  ggattcggt  tcccattag  aacacctgg  ggctggcca  gatggatct  14580
aagagctct  ccagcccca  tcctctggg  ttctttggg  gtccctgga  ggctgaaat  14640
ccttccctg  gcacaggca  cgctctcat  gtggaactt  aggctctgg  gggggattt  14700
tattttatc  cttttggac  ccttgtttc  ttgatactc  taaatgctt  ttttaggca  14760
gtaaagggt  ggaataaca  cttccagtt  tgcccagaa  tggccacgg  gagatgggc  14820
acccaaatc  gctcctgac  ggtctagag  agtcttgga  catagcctg  gatatgcag  14880
ttcctttcc  cacaccagc  cctgccagc  gtggctttt  ttttttttt  ttttttttt  14940
gagatggag  ctcgctctg  tgcccaggc  ggagtgcag  ggtgcgatc  cgactcact  15000
caacctccg  cccccgggt  caaacaatt  ttctgcctc  gcctcccga  tagctggga  15060
tacaggcgc  tgccaccat  cctggctaa  ttttgtgtt  ttagtggag  cggggtttc  15120
ccatgttgg  caggctggt  tcgaactcc  gacctcaag  gatccgcct  ccttgacct  15180
ccaaagtgc  aggattaca  gcatgagcc  ctgcccccg  cccagctat  gcttgtgat  15240
ctggccagg  gtggcggga  gggggtgga  aggagttgg  ggaggggac  catggactc  15300
gggcccatc  gtccaaccc  agaactgat  cttgacccc  tcccagcat  tctgccaac  15360
gatgggctg  cttcacctt  catgcctac  gccatgggg  gttcctccc  cctgtggca  15420
tctgttcca  ctctgggca  ctggactag  cccaaccct  ctatttgca  ttctgctcc  15480
tgtagtgac  tgcaatggg  ctgggaact  gggaaggag  cctgattct  cctttggag  15540
cttagcagg  actcaggga  gtaacgagt  gaggagggc  tgaggtgaa  tctgggccc  15600
cttgagtga  agagacttg  ccagaggga  tcctggggg  cggggagtc  gggacactg  15660
gtgtgtagg  gatgagggt  agtatgcca  tataggttg  tatgggaga  taagtcaga  15720
ccctgatgt  gactgggga  taggggctg  ccggggaag  cttctgtga  gaggtaacg  15780
gaaggacct  aagggctag  aggagttcg  taggagaag  gcaggtggc  gatcactcc  15840
gcagagggg  cagcatatg  aaaggcctg  tagcaggag  caggccttg  cctgctcaa  15900
gtaggaacg  gagactgtg  gactggaat  tggagaaga  gagggaatg  tgtcaaatt  15960
ggttgggga  gtggcaggg  cctctccaa  gcctttgta  gctctgtct  gacgcttgt  16020
atgcttgga  gaaccaggg  ccctggccc  gacgttctg  agtgctgcc  gtcctgggg  16080
agagggctc  catgatgct  agggccctt  cggccaagg  tgcgttgaa  aagttggat  16140
ttacaagga  atagaattt  gctcgatat  ggaacaaaa  ttcaaaatt  caagacgaa  16200
gaagctgcc  tctagtagg  tgagctccc  gtcagcagt  tgtaagccg  agctatact  16260
acaagaggt  taagaattg  tgttaaatt  cctcaaagc  tgaagattc  agaagtcat  16320
gattactgc  aaatgggtc  ggagccacc  agagattca  atgcatgtg  tcagatgat  16380
ggcctcagc  gaggtctct  tatggcttc  ctggctttt  aagtttctc  aaactagcg  16440
ttctcaagt  ggggtgatt  gtctcttag  ggacgtctg  caatgtcgg  gacattttt  16500
attcttatg  ttcaggaag  tgctactgg  atcttgtgg  tagagccca  gaatgctgt  16560
aaatatctc  caaggcaca  gacagctcc  caacaaaga  ttctctggc  ctaagtgtt  16620
gtggtgttg  ggtagagaa  ccctgctcc  aaccgcctc  gtggcatgt  tgcacctag  16680
agagtgggc  gagagcaga  gtggggggt  accatcctg  ccttttctg  tctctctgc  16740
gatttcgct  cctccattg  ctgctctat  cagatacac  ctggtgtcc  cagctgggt  16800
cccgatgaa  cctgaactg  tgggcaaag  ttgggcaga  acttctggg  gtgccttgg  16860
tcccaaggt  gcactgtgg  tccctggca  gtgtcttgt  ataggcagt  cctggcagg  16920
ccttcgggt  gttggcaag  ccaggatct  agtggcaat  ggcactgaa  gcaccccag  16980
cccctggga  gtgagttag  cagcccagg  gaccaggtg  accaggtgg  ggccagaga  17040
gctccaggg  ctagactcc  tcaggaggc  gaattgaaa  agggcaggg  gcacttgag  17100
tgggctggg  ctcaggggt  ctaaccctt  aggcagtga  atggcctct  ggtggggtc  17160
ggccgttgg  cctggctaa  gtctctcag  cattcccct  gggctcaag  gctgggccg  17220
ccactcctg  ctccctcat  tgtgtcccg  gttcctgaa  ggacatggg  ggaatgatg  17280
cagaatcca  ggtctgcag  acctgctgt  gttgccaac  agtctccca  agctccttg  17340
tccccaccc  ttgcgaaca  gaccagatt  tgtttggag  ctcagcatg  cggggccca  17400
atgatggag  ataacgggt  ccagccaat  gtgatgatc  tttttgctc  tttcccagc  17460
tttcttgct  ttaggggct  ccatgggac  agctctggc  agagggaac  aagcaaatc  17520
aatagagat  tttctgggg  aggttttgc  gcccactcc  catcttcct  ctataaatg  17580
gggtgtgat  gctggatct  gggcagcca  cttgctacc  tgaaggaaa  gccaagaca  17640
tcatccaca  ctattccct  cagcatctg  ttctgtaca  aaattaaat  cttatttgt  17700
taagtctct  ttggtccag  tttctgtta  atgcagcca  attgttcct  acggggtat  17760
gtctttatc  gtctatcac  gtggagatg  tgatcactt  tggtggtgt  atatgatgt  17820
tgcaaagac  atgttacag  gcctggcac  gagaaagga  gggcagagt  gctggtgac  17880
gttactagt  tgtttgtga  tcctggtgt  tgaggcggt  cacaggtgt  tgtgtgtgt  17940
tggcatgta  cttctacat  tgtctgtgc  taaacatgt  catgtgttt  ttttttttt  18000
ttttttttt  tttgagaca  agtctcact  tgttaccag  ctggagtgc  gtggcgcaa  18060
cttggctca  tgcaacctc  gcctgcagg  ttcaagcag  tctcccaat  ctcctgcct  18120
agccccctg  gtagctggg  ttacaggtg  gcaccaccg  gcccagtta  tttctgtat  18180
ttcagtaga  acagggttt  accatgttg  ccaggatgg  ctcgatctc  tgaccttga  18240
atccgcctg  ctcggcctc  caatgtact  ggattacag  cgtgagcca  cgcgcccgg  18300
ctgtggtgt  tgtttttgt  gctgtgtcg  acatgtgta  atgatgtat  catgtgagc  18360
tgtgtgctg  gaggtgtgg  gtggttcct  cttttctct  cccccaggg  ctgggttgg  18420
ggaggtcag  gaatcaggg  aggcggaat  gagactcag  gctgaggga  ttagcctca  18480
gtatcagat  atggtgcca  agggcgatt  gacagccaa  ggcaggaac  gaataaatg  18540
aagtgccct  ggaatttcc  atcccaagg  ggtggatgg  tgaatgaaa  tgatcatgg  18600
gaaatttca  gcatggtgg  acataggca  gggagggtt  gagagggga  gtctgtgtc  18660
tgcccagtg  tgcttggag  tggggtcac  gtggggctc  cagatgggg  aggaggagg  18720
gagatcccg  gggccagag  ggccctgat  cagggagcc  gggctaggg  ctccaccct  18780
gaagaatca  aaactgtct  ctggctaca  ctgtgctgg  gacatctgg  accactgag  18840
acctgaagc  agccccttt  ttttccagg  aggagaggt  cagagaggg  ctgccacat  18900
ctgtggtca  acagtgagt  gggtgcaac  ggccacttg  gcttctcca  agccccgct  18960
ctttctggg  tggcccagg  ctgggttta  gggatgcca  tcgagtgag  gcagccccc  19020
gccctgcag  cccgtgggg  tggaatggt  ccatccaca  tcgccgtcc  ccccacccc  19080
cccagggaa  gctgctcat  ggcccgcat  tagacgcgg  agcagattt  cgtgttgct  19140
ccagatcct  agggtcggg  ggagggaac  ggactcggg  catctgctg  ctccattgt  19200
ccagaatag  tgggggtag  gagggggag  agagtcagc  aggatcaga  ttgggatga  19260
ggaaggagg  agtctgagt  taacccttt  cgtgtctgc  tgggaagtt  ggaagctcc  19320
tgtgccctg  gctgaagtg  cccatctgg  ccccagagg  aggggctga  tgtggggtg  19380
ggtagcaag  ttagaccac  tagtcttgg  cttgccatg  cccttgggc  catagctgc  19440
gctgagctt  ctcccgttt  gcctgagct  tgcctgccc  ttttagggt  catgtggat  19500
agatacttt  aggaccatg  gtggtcact  atccttcgg  taggtggct  agggtaggc  19560
cccatgata  cagggacag  gagtgactc  agaacagga  ccctggcct  gggcagaca  19620
cagaaggag  ctggagatc  cctataggg  tctatggct  cctcaacca  cccctatcc  19680
cagcaagga  tgtgcaggg  cccaaggta  gtctcctct  ctcccagca  cctttttct  19740
ttttgagac  gtctcactc  gccaccgag  ctggagtgc  gtggcatga  cttggctca  19800
tgcgacttc  gcctcctgg  ttcaagtga  tcttgtgct  cagcctcct  agtagctgg  19860
attacaggc  tgtgccacc  cgcctggct  atttttgta  ttttagtag  gacagggtt  19920
tgccaagtt  gccaggctg  tttcaaact  ctgacctca  gtgatccgc  cgcctcggc  19980
tcccaaagt  ctgggatta  agatgtgcg  caccgcgcc  agccctggc  atcttttaa  20040
tgatgcacc  gctcctgct  tgagtgagg  ggactccac  ccgggaggc  ggtgaccta  20100
catctcagc  ttgcccttc  gtaagtatt  atgccagca  aactataaa  atacatatc  20160
accatcaaa  gcatgttgg  ggtcaggca  tgttctaag  acttgacat  aattaattc  20220
tttcattcc  acctatttg  agtaggtac  atcgttatt  ccgttttac  gattgggaa  20280
ctgaggcac  gaaggggag  aggtccttg  gccaggtca  aggtcttct  ggtgccaga  20340
ccaaggttg  aggcagcct  gctctgcag  ggtcatctc  ctgcgggac  actgaagag  20400
tggagaacc  cctcaggcc  gggctccac  ctgctgccc  cctgtggct  tatgccctt  20460
ggcaggtgg  ttcactgtt  actggcctc  catctgtaa  atgggcaca  tggctccta  20520
gcagcaggc  gcgaggctt  gagatgctg  atagaaagc  cctgatgcg  ggtagttgc  20580
cagtaagta  cacctctct  tccttgctg  gctcacgtt  tcagcagta  gaggttggg  20640
tactgggct  gccataacc  ccactcccc  ccttggctg  tatcacagc  gcctcctcg  20700
tgctcctgt  gtcctctct  cactgctca  tggctcctg  cacaatggc  tccttgctt  20760
ctgtggcag  tgtcatgtt  tctgccagc  ccagttctt  cctctcctt  tattgcaac  20820
ctcactcct  cacagctgg  ttgttcttg  caagctccc  tgtcccacc  cttagggag  20880
ctccccact  ccatcacac  gcagccacc  ggtggtcat  aatcacctc  tgttatagt  20940
actcataac  tgtcaccct  gcagacctg  cttccaggt  tttgtttgt  gtctactcc  21000
acctggctg  gagctccac  gtcagggat  cccttggtt  tgttccctg  agctcatga  21060
ctggcatag  agatcctca  caaatatct  aggaacgaa  agaaacata  gtgaacgga  21120
ttctcagat  tcttccagc  ctgtcagtg  tttaagatg  tatggaaga  actgaaata  21180
ctgaggcaa  gcagtgggg  ttcctaatg  agggatcag  ctggcaata  cagaacgca  21240
caagccttc  tagtatcac  cagaaagcg  tcttagtat  ctccagatg  gatcccata  21300
gaaggacac  gcacttccc  ggaagtccg  ttgctagaa  gattgaccc  acatcacct  21360
aaccctctg  acctaaaca  cagtctaca  gaagcagga  gacagtgca  catgttaaa  21420
gacaccacg  gggttcggt  tgccacatc  acaatgagg  cagtctcac  tgacgaagg  21480
cctggtttc  tcaacaagt  aaagggcat  aaaaggaag  gagtaaaga  tgttagaga  21540
gaaaataga  ttaagggat  aagtaccaa  atgcaatgt  tgggtcggg  gccatggct  21600
acgcctgta  tcccagcac  ttgggaggc  aaggtgggc  gatcacctg  ggtcaggag  21660
tccagacca  cctggccaa  atggagaaa  cctgtctct  ctgaaaata  agaaattag  21720
caggcgtgg  ggcgggcac  tgtaatccc  gctacttgg  aggctgagg  gggagaatt  21780
cttgaaccc  gaggcgaag  ttgcagtga  ccgagatcg  gctgctgca  tccagcctg  21840
gcaacgaga  tttgtttag  tctttattc  agcagacga  ccctaaaaa  gcatttttc  21900
ggaaaatga  aaaatttga  gatggactg  atattagag  atcttaagg  atggttcat  21960
ttattaggt  tggtgatga  gttgggctt  tttttagaa  tgtgctagt  tgtgagaga  22020
acattctga  atattaatg  gtgaaatga  ctgatgtct  acatttttg  taaaaaggg  22080
cttgaggga  gaatggaat  agaatggca  agtgggtat  gcagttaga  ctgggtgat  22140
ggtgcgtgg  agtgcctca  accagtccc  ctacttctg  aggggtttg  gactttcca  22200
aataaaagt  aaatggaat  aataaaagt  ggtctgtgc  tatttcatt  ctctggctg  22260
ggccctctc  ttccagctc  cccctcctc  acgccccac  ttcaggccc  gagaacatc  22320
gtttttacc  ggcacagct  tcctggccc  acttcctgt  agccccaaa  acccggaga  22380
aggaaagcc  ggccttgac  caactctgg  tcctgcctg  tttgcattt  gcctgttgc  22440
tggtttccc  gaggcccac  ctgatttct  tgggttctg  gcacttgtc  cagctgctg  22500
gtaacccag  agcacttcc  ctgggcaca  tcctctccc  actcatcct  caataattg  22560
tcgcctcct  tagcagggg  cagggaggt  gaagtgggg  tgggatggg  ccctgtgtc  22620
gatgctaca  gggacaatc  ggtgcaagc  ctgccctca  tagggagtc  caatcccag  22680
tgggacatg  ttgaaaaca  agcggccgc  cagtggctc  cacctgtaa  cccagcact  22740
tgggaggcc  aagcgggca  atcacaagg  caggagttc  agaccagcc  ggccaatat  22800
gtgacaccc  atctcttct  aaaatacaa  aattagctg  gcgtggtgg  acatgcctg  22860
aatccaagc  actcaggga  ctgaggcag  agaatcgct  gaacccggg  ggtggagat  22920
gcagtgagc  gagatcacg  cactgcact  cagcccagg  aacagagtg  gactccatc  22980
caaaaaaaa  aaaaaaaaa  aaaaaagaa  acatagcac  tcatgtaaa  aacgataat  23040
agcaaccat  tggtgcagg  agggaggac  acattctgg  gggttcagg  cgggaggaa  23100
caggcacat  gatgtgtga  gtggcgttg  gtctgggtc  taggccacg  gatctgaag  23160
agcagaatg  gtcatactg  gccttgcag  tagggccgt  gagactcca  ggaaagata  23220
agatgctgg  tatggttat  ataactacc  ttctcacat  cctatgtat  tcatcttgc  23280
ggataaagg  caggtatgt  cctggtgct  tgtctacac  aagcagaag  ggctgcctc  23340
ctccctccc  ccccacgtc  accctgcct  atgcagctc  gtgccttac  gtatctggc  23400
cagtgctgg  tacatagca  gcactccat  aagaccagc  gattattga  gtcagtgtt  23460
aaactcagt  cagtaccaa  atggctgga  agaatcaca  gcagttagg  tagttggtt  23520
aaacagatc  cagggctcc  tattagacc  tcagaaccc  aatctttaa  gaaagggcc  23580
gggaatctg  atttttacc  gccccccac  caggaggtc  taagttgct  ggttacaga  23640
ggaggtgag  gagttagag  atagttcag  accgcggac  gagccacac  gccgcttcc  23700
tcgactctc  ttcctggga  tgactagct  ggggcaagg  aggtcagtc  ctgtatgtg  23760
aagggatcc  cagtctaat  ctgatgggg  ccaggtgac  cctgtggtc  tgaccccca  23820
atgacgcag  cccggtccc  gcttcggga  caagtttca  ggaggacaa  ggtctcgct  23880
cagagacag  ttcgactgc  cagggaggg  ccgtataat  aatatcccc  cgatctctt  23940
tataagttg  aagtgaccc  catactgtg  aagcagcaa  gcatgaagc  tgagcctgt  24000
tgaacagat  aatccccca  acatggttt  agcacctac  gtgttcaag  gctgtgctg  24060
tagccacag  gcatgtagg  atgagagag  gatacagcc  ccgcctcaa  ccacctgca  24120
cttgtcaaa  atggttcat  ggttgttag  aaggagagc  gccttgaag  taaccagac  24180
ctgagtcca  tcagtgtgc  tgttagaga  gcagccagg  gagtggaga  aacagacat  24240
tggtggcag  ggcttcctg  atttgagaa  tggcactga  aagctgcgt  gccttgtgc  24300
tgtggcttc  ctctcagag  ctcggtttc  tgatctgag  actgggagt  actgcatcc  24360
tccctctat  cctgccccg  cccccagca  gtactagga  agtgcccac  tggcctggt  24420
cccaggacc  agcctgagc  ccattcatt  actcataga  tctgcattt  ctgaagacc  24480
attatatgc  agttacagt  ccagacacg  acaataagg  ggatgagag  tagcaccct  24540
ggatctgat  ctgggagag  aggcagaca  ggctcctcc  ctttttctc  tgagccccc  24600
gctgggcga  gtttctagc  tcccttgca  taagggtgg  catgtgact  agttctgcc  24660
gatggatgt  ccccacttg  agggctggc  cataaagcc  tcccccatg  ggtgatctc  24720
tttcgtctc  ttccctggc  ggtgagaga  gcctctggg  gcaagaagg  cagagcctg  24780
aggcgggag  ggcccagga  ccgaaacag  aggaggaag  ctgttcacc  aatagtggc  24840
ctgaactgt  gcaagcagc  gaaacatac  agtgttgag  tgaggccct  aattttggg  24900
tgtttgttg  agcacttag  ctgtcctga  aaacacaga  agacagaca  caagcaggt  24960
caaacaagc  ggaatttca  agacgatgg  gtgatgaag  aaataaaca  gaaggggac  25020
gtggagaat  cttggggag  atacattat  gatttcttt  cttttcttt  ttatgagac  25080
gagtcttgc  ctgtcaccc  ggctggagt  cagtggcac  atcttggct  actgcaacc  25140
ctgtcaccc  ggttcaagc  attctcctg  ctcagcctc  tgagtagct  ggattacag  25200
cgcccacca  catgcctgg  taatttttg  atttttagt  gagaaaggg  ttcaccatc  25260
tggccaggc  ggtcttgaa  tcctgacct  aggtgatcc  cccgccttg  cttcccaaa  25320
tactgggat  acaggtgtg  gccactgca  ccggcccta  acttccacg  tttaaaaaa  25380
gacattatt  atttttaaa  attgcatta  aatatatat  acaaaattt  ccattttaa  25440
cattttaac  atttttttt  tttttaaag  gacgaggtc  cactctgtt  cccaagctg  25500
agtgcagtg  cataatcag  gctcactgc  gccttgaat  cctgggttc  agtcattct  25560
tcacctcag  ctcctgagt  gctggaact  taggggcat  ccaccacac  ctggctaat  25620
taaatctac  ttttttttt  ttttttttt  tagagacag  gtcttgcca  tttgcccag  25680
ctcgtcttg  actcctggg  tcaagcgat  ctcctgcca  agcaatcct  ctgtgcttg  25740
cctttaacc  cttttaagt  tacaattca  tggcattga  tttattcac  atgttgtgt  25800
accatcacc  caacttttt  gtaatgttt  atcataatg  tttcaaggg  catccatgt  25860
tgtagcata  atcagcacc  cattccttt  tatggcagc  tactattcc  tagaatgga  25920
atgtctcag  ttgctcctg  attcatgtc  atggatatt  ggcttgctt  catcttttg  25980
ctattgcga  taatgctgg  atgaacgtg  gtatacaga  atctgtcta  gtccccact  26040
tcaagtttt  cagggcata  agccagaat  gctagatca  atgggaatt  tatgtttaa  26100
ttttttgag  acctgctgt  ctgttttcc  taggagagc  tcatgttat  ttcttacca  26160
caatgcaca  gtgttctaa  ttctccaca  catggccaa  aattatttt  ttttctttt  26220
ttttttttt  ctgagactg  gtctcactc  ttcacccag  ctagagtgc  gtgccatga  26280
ctcagctca  tgcaacctc  acctcctgt  ttcaagtga  tctcctgcc  cagcctccc  26340
agtagctgg  actacaggt  agtgccacc  cacctggct  atttttgca  ttttagtag  26400
gacagggtc  cactatgtt  gccaggctg  tctcgaact  ctggcctca  gtgatccgc  26460
tgcctcagc  tcccaaagt  ctgggatta  aggcgtgag  caccacact  gcctgtttt  26520
cttttttaa  atagccatc  tcttgggta  gaagtggca  ctcattgtg  ttttgattg  26580
cattcccct  atgattagg  atgttgaac  tctttgcag  tgttattgg  cacccattg  26640
ataatttct  tggagaaat  tctattcaa  tcttttgcc  agtttttat  caggtggtt  26700
tgttgttgt  gttgagtcc  cattctttt  tttgacagc  tcatggtat  ccacgtaat  26760
gatgtacag  tttctattg  ccagtcagt  ctctatgga  gggcatttg  atggttttc  26820
caatcatgt  cttttcaaa  aatgctaca  tgaattttc  catacacgt  ttattaagt  26880
cagatgtga  tatattgga  gattggtgg  ttaaagaga  ggtgcatct  tggccgggc  26940
cagtggctc  cgcctgtaa  ctcagcact  tgggaagcc  aggcgggtg  atcacgagg  27000
caggagttc  agaccagcc  gaccaacat  gtgaaaccg  gtccctatt  aaaatacaa  27060
aaaaattag  caggcgtgg  ggtgtgcac  tgtaatccc  gctattcag  agactgagg  27120
aggagaatc  cttcaaccc  ggaggcgga  gttgcagta  gccaagatc  caccattgc  27180
ctccagcct  ggtgacaga  tgagactcc  tctccaaaa  aaaaaaaaa  aaaaaaaag  27240
aggtgtatt  atcatttcg  tagacgctg  ccaattgtc  ttgagagtg  atgtgttcc  27300
ttttattcc  accagtcat  taagagagc  tggcgcggc  ataaaacaa  cacgtatgt  27360
ttcggcatc  tgccaaaga  ttcgtcttc  ctggggaag  taatctgac  tttcctcat  27420
ctgatgaaa  cattggcct  acattgcac  ctgtcaagg  atttgcaac  taattgcat  27480
ttgttcata  aacaattaa  attgcataa  ttgccatca  cagaactaa  tttgaccct  27540
cactatgac  aatctattc  tgctttatg  tttaaaaat  cgctcaaag  taaaaaaaa  27600
aagctacta  tcgaatacc  ttaagctga  atcaaaact  agactcgat  gcaacgtgt  27660
tcccaacct  tccaaatag  acaacattt  tttttctca  ttcctttcc  gaggtatat  27720
catgaaaat  catgagtgg  aattctttt  tcaagagta  ctaacaaga  aagggaaca  27780
ctcacatat  aaatattaa  tcagcctga  catatgata  tatacgtgg  tttagagaa  27840
cagacagca  ctctttacc  agcccacac  aaaccacat  ctcctccaa  tgtaatcaa  27900
aaagtaact  aaattgttt  ggcaaatca  ggcctaatt  aaagagata  acagatgat  27960
accccatta  ctccattat  cgaatatat  tttataatg  accagtcac  gttttcaag  28020
agaaggcgg  tgttctcaa  gggtaaaaa  tctcataaa  gaggtacta  cttgtaaat  28080
aactcagga  agcaaattc  atatgttct  taagcagct  atgtgatat  tatattaac  28140
ataataaag  tacatgcca  gtaaaacat  aggtgcagg  gaataaatg  gacattctt  28200
atcagtata  attaaagcc  tagtaaata  acattagct  tgtacttag  gtcaatcta  28260
aagctggtc  acataaata  cagctaact  ctctttcct  gcatgaaac  ttcaagttc  28320
cctagttca  cctctctcc  agcggagga  tcccaggtc  cctaaccac  gttcgcctt  28380
ctccaatga  ggtagtttc  ctatttcaa  aggcagtga  tccatgctg  ttctgattc  28440
ctgcccaaa  tgggagccg  tgattttct  ctcctctga  ggttgtcca  ggtgcacca  28500
cttcctccc  agccccctg  gattcagag  cacagagtc  cccagagat  atctttaaa  28560
ctccccagg  gatggcaag  tacagctaa  tgtgggacc  actgcccta  aatgatcat  28620
catgatctg  cttgtcagc  gtacatgca  ttgtttatt  ttcattcat  actagcatt  28680
attgaatac  cacgctagg  gctgagagt  catacatgt  atttaccta  tgtctttct  28740
tacatggac  cttttgtat  taaagacat  cgttttaaa  attaatgaa  ctgatggat  28800
agatacaat  aaactagat  cataactct  aaagaagtt  atcgctatt  tctaaaaat  28860
accctgata  tttactagt  ttattcaca  gacctttta  gaaataatg  gttcattca  28920
tccttcatt  actcattcc  ttcttcctc  ctcccacat  tgctaagtc  ctctgacag  28980
ccatacgca  tgacaggca  cctcccttg  cccctgctg  aaaatgctc  gtgtctacc  29040
gccacccac  gtcacaccc  ctgctgctg  aacaggaat  gagctgttc  cagcttctt  29100
gggccttta  gaagcacat  cttagggct  tgtgctcct  ccacaggtg  ccacccttt  29160
cttcaccca  ccaggcagt  ctggaggtg  gtgtgggga  tgctgctac  tggctggat  29220
cggggtagg  gtcccagtg  acagtgcag  acatcacca  cagggggca  tcatgcatc  29280
ccactggct  ctcacctgg  ccagggcaa  gcaggcctg  ctggaaggt  aagatgact  29340
gggtgccac  gaggggacc  ggctaggct  gggaggggc  ctatgggat  aaagggcac  29400
aaagtgggc  ccttgcact  agattctaa  aaaatcctc  ccagccagg  ggaagaaaa  29460
cacacagca  gtctcctta  cagatttaa  aaacatgac  atctggggg  cagcagcca  29520
cagttaaat  atcctgcca  ttggtgagg  gcaaggttg  ctctcaggc  catgctggt  29580
ctttgtagg  agaggagtg  gacagagag  agaccttca  gccaatggg  ctctcctgg  29640
gactggccc  catatcccc  cctccagcc  agccaggag  agaccagtc  gggtggccc  29700
ggccttctg  aactgtcct  taccagtcc  ttgggcctc  tgttcccct  ctgcaatca  29760
tcccaccct  cctgctttt  ctgggagca  gaaggtgga  gtgtgttgc  aacagagga  29820
agccatcta  acaaaaaca  gggaatcta  aatggagct  gcctgcccc  atcctgcca  29880
ccccttcct  cttcggaat  tgtgtgcat  tgtaatctg  gagtctgtc  cattgtgca  29940
tgctggagc  gacgattag  tgcagtggt  gctctcgcc  tgccctctg  tgacttttc  30000
ctaattggt  taatctgta  tttcacgca  tcactggaa  atgagaaga  ccgccagct  30060
ctccgagga  ctgggatga  gcgtgaacc  tacgagaag  gtcgcgggg  tttgcggct  30120
ctgccatgg  ggctgggga  gtcacagga  aatggcaga  tgtccttgt  cttgggtac  30180
cacagtccc  gggcgagga  gggcacgaa  ggaggaggt  cagaaggcg  aaacgtact  30240
ggggcctgc  tacctggga  aggagaggt  gggagagga  accctgact  gggttggct  30300
cccccgggc  gaatgtctg  ccgttcagg  gcaggaacg  gggcaccca  gcagagaga  30360
cccaggggc  gagtgtgag  atctcagtg  cagctactt  tgtttctgt  gctttctct  30420
ggataggac  attctgtgg  cctctctct  gatttgtca  gactttggg  agacagctc  30480
gtgggtgtc  gagtctagt  tgttgtctg  gtgtatgag  gcatgagtg  gtgtgtatg  30540
gtgtgagtt  ggtgtgacc  ctggtggct  ctaactctc  attgcattc  gcttccagc  30600
ctgcagggt  tccttgttg  acctctggg  atcctgcct  gggacagag  tggctaatg  30660
agcaggggg  gggggtggg  ctagcctag  tagaggctt  agcccctac  gctggggta  30720
agcgattac  agcgtgtgt  tgtgtgtgt  tgtgtgtgc  cgcgcgcgc  cgcgtatgt  30780
tgtgtgcgc  tttagtggc  gcagaatcc  caaccaccc  gagagggtc  aaatacttg  30840
ccctggcct  ccctccctt  ccttgccat  attcgcagc  ccccagctg  cctcgatat  30900
ttcatttac  ctaagacgc  gtgctctga  attgcttct  ctcctcgga  ttctctggc  30960
ctgatagtg  aatttccac  agtgtcaga  gggagacag  ttgggatgt  gggagcttc  31020
tgatgctgc  ttagagaca  gtacaaatt  ggacccttg  ccttgcgtt  gacaagtga  31080
tcacttata  tcaccactt  tttttactt  catcaacct  accaagacg  agagctttg  31140
gttgctcct  ctggcgcca  gagccccta  gcagggtta  tgatgataa  agaagtgag  31200
gtgactcag  agatggaat  ttccaatgc  ggtgagtaa  ttcagtttc  tataacaaa  31260
agacaataa  gaaattagg  tctcaccgt  aacctgaga  tggtgctga  ccttaatag  31320
ccctcctgt  tagcaggca  cgctgtaag  tcttcccag  tcagccgcc  tctgttgcc  31380
atttcacag  tgaagaaac  aaggcacaa  gaagtgaag  aatttgccc  gagattaac  31440
agttcacgg  gcagggatg  gagcccagg  agtctaggg  ccttgccaa  tacccagcc  31500
ctgtgccct  cattgcagg  cagccccgc  cgtggtcac  gtgtggaat  catggtgtt  31560
cctgcagca  agccgcaaa  cttagtctt  ccggagagc  tcttgccag  gacttgatt  31620
cacatggca  agaaagagt  ggacaggtt  aaaagaggc  tttactata  ccaactggt  31680
ttcacttcg  gtgtctgtt  tctgtggtt  gtaaatatt  tccggcttc  ccttgat  31737



<210> 5476
<211> 321
<212> PRT
<213> Homo sapiens
<308> CAB07511
<400> 5476

Met Gln Cys Arg Leu Pro Arg Gly Leu Ala Gly Ala Leu Leu Thr Leu 
  1               5                  10                  15
Leu Cys Met Gly Leu Leu Cys Leu Arg Tyr His Leu Asn Leu Ser Pro 
             20                  25                  30
Gln Arg Val Gln Gly Thr Pro Glu Leu Ser Gln Pro Asn Pro Gly Pro 
         35                  40                  45
Pro Lys Leu Gln Leu His Asp Val Phe Ile Ala Val Lys Thr Thr Arg 
     50                  55                  60
Ala Phe His Arg Leu Arg Leu Glu Leu Leu Leu Asp Thr Trp Val Ser 
 65                  70                  75                  80
Arg Thr Arg Glu Gln Thr Phe Val Phe Thr Asp Ser Pro Asp Lys Gly 
                 85                  90                  95
Leu Gln Glu Arg Leu Gly Ser His Leu Val Val Thr Asn Cys Ser Ala 
             100                105                110
Glu His Ser His Pro Ala Leu Ser Cys Lys Met Ala Ala Glu Phe Asp 
         115                120                125
Thr Phe Leu Ala Ser Gly Leu Arg Trp Phe Cys His Val Asp Asp Asp 
     130                135                140
Asn Tyr Val Asn Pro Arg Ala Leu Leu Gln Leu Leu Arg Ala Phe Pro 
 145                150                155                160
Leu Ala Arg Asp Val Tyr Val Gly Arg Pro Ser Leu Asn Arg Pro Ile 
                 165                170                175
His Ala Ser Glu Pro Gln Pro His Asn Arg Thr Arg Leu Val Gln Phe 
             180                185                190
Trp Phe Ala Thr Gly Gly Ala Gly Phe Cys Ile Asn Arg Lys Leu Ala 
         195                200                205
Leu Lys Met Ala Pro Trp Ala Ser Gly Ser Arg Phe Met Asp Thr Ser 
     210                215                220
Ala Leu Ile Arg Leu Pro Asp Asp Cys Thr Met Gly Tyr Ile Ile Glu 
 225                230                235                240
Cys Lys Leu Gly Gly Arg Leu Gln Pro Ser Pro Leu Phe His Ser His 
                 245                250                255
Leu Glu Thr Leu Gln Leu Leu Arg Thr Ala Gln Leu Pro Glu Gln Val 
             260                265                270
Thr Leu Ser Tyr Gly Val Phe Glu Gly Lys Leu Asn Val Ile Lys Leu 
         275                280                285
Gln Gly Pro Phe Ser Pro Glu Glu Asp Pro Ser Arg Phe Arg Ser Leu 
     290                295                300
His Cys Leu Leu Tyr Pro Asp Thr Pro Trp Cys Pro Gln Leu Gly Ala 
 305                310                315                320
Arg 
                 325



<210> 5477
<211> 381
<212> DNA
<213> Rattus norvegicus
<308> AA891666
<400> 5477

aaacagaat  gtccaggtt  attcacagg  aggacgtct  cgggcctgc  gctgtatat  60
cctccacac  cagtcaagg  aagacttct  tggcctcct  agctgatat  tcctgggag  120
agagatctg  gaagagagc  ggcagccag  agtgggcct  ccctggtgc  tgcagatcc  180
gccaggcca  tccttcctt  agcaggtgt  ccagcactt  ccgtgctcg  tccgtctcc  240
atttaagac  ggctttgat  tcactgaca  tcacataac  gtttttctc  gccagctgc  300
gcacaacag  gtgatccat  ttgagctca  ctggaacag  ctgaatgag  taagttccc  360
ccacaggga  gatgccaaa  c  381



<210> 5478
<211> 775
<212> PRT
<213> Rattus norvegicus
<308> Q9ES73
<400> 5478

Met Ala Gln Lys Pro Asp Gly Gly Ala Gly Leu Arg Gly Phe Gln Ala 
  1               5                  10                  15
Glu Ala Ser Val Glu Asp Ser Ala Leu Leu Val Gln Thr Leu Met Glu 
             20                  25                  30
Ala Ile Gln Ile Ser Glu Ala Pro Pro Thr Ser Gln Ala Thr Ala Ala 
         35                  40                  45
Ala Ser Gly Pro Asn Ala Ser Pro Gln Ser Ser Gln Pro Pro Thr Ala 
     50                  55                  60
Asn Glu Lys Ala Asp Thr Glu Val Ser Ala Ala Ala Ala Arg Pro Lys 
 65                  70                  75                  80
Thr Gly Phe Lys Ala Gln Asn Thr Thr Thr Lys Gly Pro Asn Asp Tyr 
                 85                  90                  95
Ser Gln Ala Arg Asn Ala Lys Glu Met Pro Lys Asn Gln Pro Lys Val 
             100                105                110
Ala Phe Lys Ser Gln Asn Ala Thr Ser Lys Gly Pro His Ala Ala Ser 
         115                120                125
Asp Phe Ser His Ala Ala Ser Thr Gly Lys Ser Ala Ala Lys Lys Ser 
     130                135                140
Glu Met Ala Phe Lys Gly Gln Asn Thr Thr Thr Lys Ala Gly Pro Ser 
 145                150                155                160
Ala Thr Tyr Asn Phe Thr Gln Ser Pro Ser Ala Asn Glu Met Thr Asn 
                 165                170                175
Asn Gln Pro Lys Thr Ala Lys Ala Trp Asn Asp Thr Thr Lys Ile Pro 
             180                185                190
Gly Ala Asp Ala Gln Thr Gln Asn Val Asn Gln Ala Lys Met Ala Asp 
         195                200                205
Val Gly Thr Ser Ala Gly Ile Ser Glu Thr Asp Gly Ala Ala Ala Gln 
     210                215                220
Thr Ser Ala Asp Gly Ser Gln Ala Gln Asn Val Glu Ser Arg Thr Ile 
 225                230                235                240
Ile Arg Gly Lys Arg Thr Arg Lys Ile Asn Asn Leu Asn Val Glu Glu 
                 245                250                255
Asn Ser Asn Gly Asp Gln Arg Arg Ala Ser Leu Ala Ser Gly Asn Trp 
             260                265                270
Arg Ser Ala Pro Val Pro Val Thr Thr Gln Asn Pro Pro Gly Ala Pro 
         275                280                285
Pro Asn Val Leu Trp Gln Thr Pro Leu Ala Trp Gln Asn Pro Ser Gly 
     290                295                300
Trp Gln Asn Gln Thr Ala Arg Gln Thr Pro Pro Ala Arg Gln Ser Pro 
 305                310                315                320
Pro Ala Arg Gln Thr Pro Ser Ala Trp Gln Asn Pro Val Ala Trp Gln 
                 325                330                335
Asn Pro Val Ile Trp Pro Asn Pro Val Ile Trp Gln Asn Pro Val Ile 
             340                345                350
Trp Pro Asn Pro Ile Val Trp Pro Gly Pro Ile Val Trp Pro Asn Pro 
         355                360                365
Met Ala Trp Gln Ser Thr Pro Gly Trp Gln Ser Pro Pro Ser Trp Gln 
     370                375                380
Ala Pro Pro Ser Trp Gln Ser Pro Gln Asp Trp Gln Gly Pro Pro Asp 
 385                390                395                400
Trp Gln Leu Pro Pro Asp Trp Ser Met Pro Pro Asp Trp Ser Phe Pro 
                 405                410                415
Ser Asp Trp Pro Phe Pro Pro Asp Cys Ile Leu Ala Asp Trp Pro Ile 
             420                425                430
Pro Pro Asp Trp Gln Asn Leu Arg Pro Ser Pro Asn Leu Arg Ser Ser 
         435                440                445
Pro Asn Ser Arg Ala Ser Gln Asn Gln Gly Pro Pro Gln Pro Arg Asp 
     450                455                460
Val Ala Leu Leu Gln Glu Arg Ala Asn Lys Leu Val Lys Tyr Leu Met 
 465                470                475                480
Leu Lys Asp Tyr Thr Lys Val Pro Ile Lys Arg Ser Glu Met Leu Arg 
                 485                490                495
Asp Ile Ile Arg Glu Tyr Thr Asp Val Tyr Pro Glu Ile Ile Glu Arg 
             500                505                510
Ala Cys Phe Val Leu Glu Lys Lys Phe Gly Ile Gln Leu Lys Glu Ile 
         515                520                525
Asp Lys Glu Glu His Leu Tyr Ile Leu Ile Ser Thr Pro Glu Ser Leu 
     530                535                540
Ala Gly Ile Leu Gly Thr Thr Lys Asp Thr Pro Lys Leu Gly Leu Leu 
 545                550                555                560
Leu Val Ile Leu Gly Ile Ile Phe Met Asn Gly Asn Arg Ala Thr Glu 
                 565                570                575
Ala Val Leu Trp Glu Ala Leu Arg Lys Met Gly Leu Arg Pro Gly Val 
             580                585                590
Arg His Pro Leu Leu Gly Asp Leu Arg Lys Leu Leu Thr Tyr Glu Phe 
         595                600                605
Val Lys Gln Lys Tyr Leu Asp Tyr Arg Arg Val Pro Asn Ser Asn Pro 
     610                615                620
Pro Glu Tyr Glu Phe Leu Trp Gly Leu Arg Ser Tyr His Glu Thr Ser 
 625                630                635                640
Lys Met Lys Val Leu Arg Phe Ile Ala Glu Val Gln Lys Arg Asp Pro 
                 645                650                655
Arg Asp Trp Thr Ala Gln Phe Met Glu Ala Ala Asp Glu Ala Leu Asp 
             660                665                670
Ala Leu Asp Ala Ala Ala Ala Glu Ala Glu Ala Arg Ala Glu Ala Arg 
         675                680                685
Asn Arg Met Gly Leu Glu Thr Glu Leu Cys Leu Gly Pro Trp Ser Trp 
     690                695                700
Asp Asp Ile Glu Phe Glu Leu Leu Thr Trp Asp Glu Glu Gly Asp Phe 
 705                710                715                720
Gly Asp Pro Trp Ser Arg Ile Pro Phe Thr Phe Trp Ala Arg Tyr His 
                 725                730                735
Gln Asn Ala Arg Ser Arg Phe Pro Gln Ala Phe Thr Gly Pro Ile Ile 
             740                745                750
Gly Pro Ser Gly Thr Ala Thr Ala Asn Phe Ala Ala Asn Phe Gly Ala 
         755                760                765
Ile Gly Phe Phe Trp Val Glu 
     770                775



<210> 5479
<211> 5441
<212> DNA
<213> Homo sapiens
<308> AK074092
<400> 5479

ggacaagga  agagtgcgg  tgctgagag  cgagcccag  aatcccgat  ctctgagtc  60
tgaagaagg  aggcagcga  ggggttggg  ttggggcct  aggcaagcc  ccaggctcc  120
ctcttgcca  agggacagg  gccatggct  agaaaatgg  ctgtggtgc  ggcctcctc  180
gcttccagg  tgaggcctc  gtagaagac  gcgccttgc  tatgcagac  ttgatggag  240
ccatccaga  ctcagaggc  ccacctact  accaggcca  cgcagctgc  agtccccag  300
gttcacagc  cccaactgc  aatgagatg  ctgacattc  ggtttcagc  gctgccgct  360
ggcctaagt  agcctttaa  gtccagaat  ccaccacaa  aggcccaaa  ggtgtctat  420
atttctctc  ggctcataa  gccaaggat  tgcccaaca  gcagcccaa  gcagccttt  480
agtcccaaa  tgctacccc  aagggtcca  atgctgcct  tgatttttc  caggcagca  540
ccactggtg  gttagctgc  aacaagtct  agatggcct  caaggccca  aatgccact  600
ctaaagtgg  cccaaatgc  acctacaat  tctctcagt  tctcaatgc  aatgacctg  660
ccaacagca  gcctaagac  cctttcaag  cttggaatg  taccactaa  gccccaaca  720
ctgataccc  gacccagaa  gtaaatcag  ccaaaatgg  cacttccca  gctgacata  780
agaccgacc  aggtatctc  gaacctgac  gtgcaactg  acagacatc  gcagatggt  840
cccaggctc  gaatctgga  tcccggaca  taattcggg  caagaggac  cgcaagatt  900
ataacttga  tgttgaaga  aacagcagt  gggatcaga  gcgggcccc  ctggctgca  960
ggacctgga  gtctgcacc  gttccagtg  ccactcaga  cccacctgg  gcacccccc  1020
atgtgtctg  cagacgcca  tggcttggc  gaacccctc  gggctggca  aaccagaca  1080
ccaggcaga  ccaacagca  gtcagagcc  tccagctag  cagaaccca  ccagcctgg  1140
agaacccag  cgcttggca  aacccagtg  tttggccaa  cccagtaat  tggcagaac  1200
cagtgatct  gccaaaccc  attgtctgg  ccggccctg  tgtctggcc  aatccactg  1260
cctggcaga  tccacctgg  tggcagact  cacctggat  gcagacccc  ccgggctgg  1320
agggtcctc  agactggca  ggtcctcct  actggccgc  accacccga  tggccactg  1380
cacctgatt  gccacttcc  actgactgg  cactaccac  tgactggat  cccgctgat  1440
ggccaattc  acctgactg  cagaacctg  gcccctcgc  taacctgcg  ccttctccc  1500
actcgcgtg  ctcacagaa  ccaggtgct  cacagcccc  agatgtggc  cttcttcag  1560
aaagagtaa  agctgtaac  ccccagtca  ttttcccct  tcttgctct  ttctttgtc  1620
tcctctcat  tgtaattca  ccaagtttt  ttgtaaata  tttataagt  taatgattt  1680
ctttttccc  cccaggcaa  taagttggt  aagtacttg  tgcttaagg  ctacacaaa  1740
gtgcccatc  agcgctcag  tatgcatcc  gtgtcccct  cccaagctc  gcccttccc  1800
tcactccat  ctctgtcag  attcttctg  ttgtagctc  gcccttccc  tcactccat  1860
ctctgtcgg  attcttctg  ttgtatgac  cttcccctt  tatcccctc  tttccatgg  1920
tggctcttt  cacccttga  gaccttgac  gtgctaccc  cagcagggc  ggcaaaggg  1980
ctgctgctc  gtggccccc  ctcggctca  atggctccc  cctctctcc  acagaaatg  2040
tgagagata  catccgtga  tacactgat  tttatccag  aatcattga  cgtgcatgc  2100
ttgtcctag  gaagaaatt  gggattcaa  tgaaagaaa  tgacaaaga  gaacacctg  2160
atattctca  cagtacccc  gagtccctg  ctggcatac  gggaacgta  gatgggaaa  2220
aaggtggaa  atggccttt  tcagtggtg  tttttttct  ggagtttca  gtagatcag  2280
gtccagggt  cagggtcac  tagcaggtc  tgggcagag  tggggtata  ttctcccct  2340
gctgaggaa  attggggag  ctagatggg  aagctggtt  gggtctctc  tgcaaatgg  2400
tactgaaaa  atattcttt  tatattccc  taggaccaa  gacacaccc  agctcggtc  2460
cctcttggt  attctgggt  tcatcttca  gaatggcaa  cgtgccagt  agggtgagt  2520
gctggacct  cagctgggg  ttggccaca  cctgatttc  atgcttatt  tccgtccct  2580
gtctcccct  gcctcccat  gcagctgtc  tctgggagg  actacgcaa  atgggactg  2640
gtcctgggt  tgattgggc  ctctcatct  ttgcctgtt  gtgccatcc  ttggcaaca  2700
tggatggtc  caggattgc  ttaacctgg  ggtctggag  gtttggttt  gggatgttc  2760
gagcccaaa  atgtgacct  ggtggatgg  gaaacagtt  tgaactctc  gcctctttt  2820
tcatctctg  cctctgttc  ggaaagctc  ttgggcatg  taatagcct  tgattgtgg  2880
tttcctttt  ttaccttca  ggtgagaca  cccctcctt  gagatctaa  gaaacttct  2940
acctatgag  ttgtaaagc  gaagtaagt  atgcctaag  ggcttttcc  gcttcttat  3000
attctgcct  tgtgctggt  agctttaga  agcccttcc  ggctggata  aatggctca  3060
gcctgtaat  ccagtactt  gggaggctc  ggtgggcgg  tcgcttgag  ccgggagtt  3120
gagaccagc  tgggcaaca  gacgaaacc  cgtctctac  aaaaaatac  aaaattagc  3180
aggcgtggt  acatgcacc  gtggtccca  ctacttggg  ggctgaggt  ggggagaat  3240
atctgagcc  aggaagttg  ggctgcggt  ggctgtgat  atgccactg  actccaacc  3300
gggcaacag  gtgagaccc  gtctcaaaa  aaataaaag  aagcccttc  caagctcgt  3360
tcttacact  tacttgtgc  tatgtgttt  tgtgcatac  gaaacactt  tgtcctcag  3420
agtatttat  gcatatact  ctcatggtt  aattcttta  tttttattt  tttattttt  3480
gagacggag  ttcgctctt  ttgcccagg  tggagtgca  tggcgtgat  tcggctcac  3540
gcaacctct  cctcctggg  tcaagctat  ctcctgcct  agcctcttg  gtagctggg  3600
ttacaggca  gtgccacca  gcccaccta  ttttgtctt  ttagtagag  cggtgtttc  3660
ccatgttag  ctggtctcg  actcccgac  tcaggtgat  tgcctgcct  ggcctccag  3720
agtgctgag  ttacaggcg  gagcgaccg  accgggcga  ttcttttgt  tgttttttt  3780
gagactgag  ctcactctg  tgcccatgc  ggagtgcag  ggtgcaatc  tggctcgct  3840
gaacttcca  ctcccaggt  caagcaatt  ttgtgcctc  gcctcccga  taactggaa  3900
ttcaggtgc  tgccaccgt  cccggctgt  tttgtattt  tagtagaga  ggggcttca  3960
cacgttggc  aggctggtc  caaactcct  acctgaagc  atccaccca  ctctgcctc  4020
caaagtgct  ggattacag  tgtgagcca  cacacccgg  cagaatttt  ctaattttt  4080
tacttttct  agcagttgt  ttgcaagtg  agcccatcc  ccatcccca  agtagacat  4140
cccaaggct  ggccaggct  acacttttg  actgcattg  actcatttc  atggacctc  4200
gtggctcac  gacaagatt  caagaatct  gagctagag  tgaggcaga  ggagtgaaa  4260
gaaatgttg  cctttctgt  accctatac  agcctcgcc  gcatctcta  tgagtgctt  4320
gcgttctag  gcaggaatt  aaggcttga  gattaaggg  taaataccc  gatggtgtt  4380
aggaatgag  ccaaggggg  gttgctatc  gaaatctgt  aaaaaatgt  agattattt  4440
tcattagtg  actaccatt  tgcctgggt  ggtagacac  aagactgtt  tgctctttc  4500
gatacctgg  ctacagacg  gtgcccaac  gcaaccccc  ggagtatga  ttcctctgg  4560
gcctccgtt  ctaccatga  actagcaag  tgaaagtgc  gagattcat  gcagaggtt  4620
agaaaagag  ccctcgtga  tggactgca  agttcatgg  ggctgcaga  gaggccttg  4680
atgctctgg  tgctgctgc  gctgaggcc  aagcccggg  tgaagcaag  acccgcatg  4740
gaattggag  tgaggctgt  tctgggccc  ggagctggg  tgacattga  tttgagctg  4800
tgacctggg  tgaggaagg  gattttgga  atccctggt  cagaattcc  tttaccttc  4860
gggccagat  ccaccagaa  gcccgctcc  gattccctc  gacctttgc  ggtcccatt  4920
ttggtcctg  tggtacagc  agtgccaac  tcgctgcca  ctttggtgc  attggtttc  4980
tctgggttg  gtgagatgt  gggtaggta  atcactttg  attgggcag  tagggtctc  5040
gggggatat  gggtccatg  ggttgtatt  atgtgcatg  gctagaagt  ttaggaaac  5100
cattgtagg  agatgagga  agtatgggg  agcactctt  ggtatgtat  ttccttatt  5160
tttgatata  atcattgat  tttttactt  ttctttctt  tgttcacag  tattgctat  5220
aatcgcagt  gtctttccc  tgtgtgagg  tgaagcctc  gattccttc  aaacacagc  5280
atctagaga  ccacatcct  ttgactgaa  gtggcatgc  agataaatt  atttgctgt  5340
ccttgtcta  tgctttttt  ccccttgtg  gctgtcaag  tttggtatc  gaaataaac  5400
ttgaaattg  aaagtgaaa  aaaaaaaaa  aaaaaaaaa  g  5441



<210> 5480
<211> 778
<212> PRT
<213> Homo sapiens
<308> Q9Y5V3
<400> 5480

Met Ala Gln Lys Met Asp Cys Gly Ala Gly Leu Leu Gly Phe Gln Ala 
  1               5                  10                  15
Glu Ala Ser Val Glu Asp Ser Ala Leu Leu Met Gln Thr Leu Met Glu 
             20                  25                  30
Ala Ile Gln Ile Ser Glu Ala Pro Pro Thr Asn Gln Ala Thr Ala Ala 
         35                  40                  45
Ala Ser Pro Gln Ser Ser Gln Pro Pro Thr Ala Asn Glu Met Ala Asp 
     50                  55                  60
Ile Gln Val Ser Ala Ala Ala Ala Arg Pro Lys Ser Ala Phe Lys Val 
 65                  70                  75                  80
Gln Asn Ala Thr Thr Lys Gly Pro Asn Gly Val Tyr Asp Phe Ser Gln 
                 85                  90                  95
Ala His Asn Ala Lys Asp Val Pro Asn Thr Gln Pro Lys Ala Ala Phe 
             100                105                110
Lys Ser Gln Asn Ala Thr Ser Lys Gly Pro Asn Ala Ala Tyr Asp Phe 
         115                120                125
Ser Gln Ala Ala Thr Thr Gly Glu Leu Ala Ala Asn Lys Ser Glu Met 
     130                135                140
Ala Phe Lys Ala Gln Asn Ala Thr Thr Lys Val Gly Pro Asn Ala Thr 
 145                150                155                160
Tyr Asn Phe Ser Gln Ser Leu Asn Ala Asn Asp Leu Ala Asn Ser Arg 
                 165                170                175
Pro Lys Thr Pro Phe Lys Ala Trp Asn Asp Thr Thr Lys Ala Pro Thr 
             180                185                190
Ala Asp Thr Gln Thr Gln Asn Val Asn Gln Ala Lys Met Ala Thr Ser 
         195                200                205
Gln Ala Asp Ile Glu Thr Asp Pro Gly Ile Ser Glu Pro Asp Gly Ala 
     210                215                220
Thr Ala Gln Thr Ser Ala Asp Gly Ser Gln Ala Gln Asn Leu Glu Ser 
 225                230                235                240
Arg Thr Ile Ile Arg Gly Lys Arg Thr Arg Lys Ile Asn Asn Leu Asn 
                 245                250                255
Val Glu Glu Asn Ser Ser Gly Asp Gln Arg Arg Ala Pro Leu Ala Ala 
             260                265                270
Gly Thr Trp Arg Ser Ala Pro Val Pro Val Thr Thr Gln Asn Pro Pro 
         275                280                285
Gly Ala Pro Pro Asn Val Leu Trp Gln Thr Pro Leu Ala Trp Gln Asn 
     290                295                300
Pro Ser Gly Trp Gln Asn Gln Thr Ala Arg Gln Thr Pro Pro Ala Arg 
 305                310                315                320
Gln Ser Pro Pro Ala Arg Gln Thr Pro Pro Ala Trp Gln Asn Pro Val 
                 325                330                335
Ala Trp Gln Asn Pro Val Ile Trp Pro Asn Pro Val Ile Trp Gln Asn 
             340                345                350
Pro Val Ile Trp Pro Asn Pro Ile Val Trp Pro Gly Pro Val Val Trp 
         355                360                365
Pro Asn Pro Leu Ala Trp Gln Asn Pro Pro Gly Trp Gln Thr Pro Pro 
     370                375                380
Gly Trp Gln Thr Pro Pro Gly Trp Gln Gly Pro Pro Asp Trp Gln Gly 
 385                390                395                400
Pro Pro Asp Trp Pro Leu Pro Pro Asp Trp Pro Leu Pro Pro Asp Trp 
                 405                410                415
Pro Leu Pro Thr Asp Trp Pro Leu Pro Pro Asp Trp Ile Pro Ala Asp 
             420                425                430
Trp Pro Ile Pro Pro Asp Trp Gln Asn Leu Arg Pro Ser Pro Asn Leu 
         435                440                445
Arg Pro Ser Pro Asn Ser Arg Ala Ser Gln Asn Pro Gly Ala Ala Gln 
     450                455                460
Pro Arg Asp Val Ala Leu Leu Gln Glu Arg Ala Asn Lys Leu Val Lys 
 465                470                475                480
Tyr Leu Met Leu Lys Asp Tyr Thr Lys Val Pro Ile Lys Arg Ser Glu 
                 485                490                495
Met Leu Arg Asp Ile Ile Arg Glu Tyr Thr Asp Val Tyr Pro Glu Ile 
             500                505                510
Ile Glu Arg Ala Cys Phe Val Leu Glu Lys Lys Phe Gly Ile Gln Leu 
         515                520                525
Lys Glu Ile Asp Lys Glu Glu His Leu Tyr Ile Leu Ile Ser Thr Pro 
     530                535                540
Glu Ser Leu Ala Gly Ile Leu Gly Thr Thr Lys Asp Thr Pro Lys Leu 
 545                550                555                560
Gly Leu Leu Leu Val Ile Leu Gly Val Ile Phe Met Asn Gly Asn Arg 
                 565                570                575
Ala Ser Glu Ala Val Leu Trp Glu Ala Leu Arg Lys Met Gly Leu Arg 
             580                585                590
Pro Gly Val Arg His Pro Leu Leu Gly Asp Leu Arg Lys Leu Leu Thr 
         595                600                605
Tyr Glu Phe Val Lys Gln Lys Tyr Leu Asp Tyr Arg Arg Val Pro Asn 
     610                615                620
Ser Asn Pro Pro Glu Tyr Glu Phe Leu Trp Gly Leu Arg Ser Tyr His 
 625                630                635                640
Glu Thr Ser Lys Met Lys Val Leu Arg Phe Ile Ala Glu Val Gln Lys 
                 645                650                655
Arg Asp Pro Arg Asp Trp Thr Ala Gln Phe Met Glu Ala Ala Asp Glu 
             660                665                670
Ala Leu Asp Ala Leu Asp Ala Ala Ala Ala Glu Ala Glu Ala Arg Ala 
         675                680                685
Glu Ala Arg Thr Arg Met Gly Ile Gly Asp Glu Ala Val Ser Gly Pro 
     690                695                700
Trp Ser Trp Asp Asp Ile Glu Phe Glu Leu Leu Thr Trp Asp Glu Glu 
 705                710                715                720
Gly Asp Phe Gly Asp Pro Trp Ser Arg Ile Pro Phe Thr Phe Trp Ala 
                 725                730                735
Arg Tyr His Gln Asn Ala Arg Ser Arg Phe Pro Gln Thr Phe Ala Gly 
             740                745                750
Pro Ile Ile Gly Pro Gly Gly Thr Ala Ser Ala Asn Phe Ala Ala Asn 
         755                760                765
Phe Gly Ala Ile Gly Phe Phe Trp Val Glu 
     770                775



<210> 5481
<211> 381
<212> DNA
<213> Rattus norvegicus
<308> AA891666
<400> 5481

aaacagaat  gtccaggtt  attcacagg  aggacgtct  cgggcctgc  gctgtatat  60
cctccacac  cagtcaagg  aagacttct  tggcctcct  agctgatat  tcctgggag  120
agagatctg  gaagagagc  ggcagccag  agtgggcct  ccctggtgc  tgcagatcc  180
gccaggcca  tccttcctt  agcaggtgt  ccagcactt  ccgtgctcg  tccgtctcc  240
atttaagac  ggctttgat  tcactgaca  tcacataac  gtttttctc  gccagctgc  300
gcacaacag  gtgatccat  ttgagctca  ctggaacag  ctgaatgag  taagttccc  360
ccacaggga  gatgccaaa  c  381



<210> 5482
<211> 775
<212> PRT
<213> Rattus norvegicus
<308> Q9ES73
<400> 5482

Met Ala Gln Lys Pro Asp Gly Gly Ala Gly Leu Arg Gly Phe Gln Ala 
  1               5                  10                  15
Glu Ala Ser Val Glu Asp Ser Ala Leu Leu Val Gln Thr Leu Met Glu 
             20                  25                  30
Ala Ile Gln Ile Ser Glu Ala Pro Pro Thr Ser Gln Ala Thr Ala Ala 
         35                  40                  45
Ala Ser Gly Pro Asn Ala Ser Pro Gln Ser Ser Gln Pro Pro Thr Ala 
     50                  55                  60
Asn Glu Lys Ala Asp Thr Glu Val Ser Ala Ala Ala Ala Arg Pro Lys 
 65                  70                  75                  80
Thr Gly Phe Lys Ala Gln Asn Thr Thr Thr Lys Gly Pro Asn Asp Tyr 
                 85                  90                  95
Ser Gln Ala Arg Asn Ala Lys Glu Met Pro Lys Asn Gln Pro Lys Val 
             100                105                110
Ala Phe Lys Ser Gln Asn Ala Thr Ser Lys Gly Pro His Ala Ala Ser 
         115                120                125
Asp Phe Ser His Ala Ala Ser Thr Gly Lys Ser Ala Ala Lys Lys Ser 
     130                135                140
Glu Met Ala Phe Lys Gly Gln Asn Thr Thr Thr Lys Ala Gly Pro Ser 
 145                150                155                160
Ala Thr Tyr Asn Phe Thr Gln Ser Pro Ser Ala Asn Glu Met Thr Asn 
                 165                170                175
Asn Gln Pro Lys Thr Ala Lys Ala Trp Asn Asp Thr Thr Lys Ile Pro 
             180                185                190
Gly Ala Asp Ala Gln Thr Gln Asn Val Asn Gln Ala Lys Met Ala Asp 
         195                200                205
Val Gly Thr Ser Ala Gly Ile Ser Glu Thr Asp Gly Ala Ala Ala Gln 
     210                215                220
Thr Ser Ala Asp Gly Ser Gln Ala Gln Asn Val Glu Ser Arg Thr Ile 
 225                230                235                240
Ile Arg Gly Lys Arg Thr Arg Lys Ile Asn Asn Leu Asn Val Glu Glu 
                 245                250                255
Asn Ser Asn Gly Asp Gln Arg Arg Ala Ser Leu Ala Ser Gly Asn Trp 
             260                265                270
Arg Ser Ala Pro Val Pro Val Thr Thr Gln Asn Pro Pro Gly Ala Pro 
         275                280                285
Pro Asn Val Leu Trp Gln Thr Pro Leu Ala Trp Gln Asn Pro Ser Gly 
     290                295                300
Trp Gln Asn Gln Thr Ala Arg Gln Thr Pro Pro Ala Arg Gln Ser Pro 
 305                310                315                320
Pro Ala Arg Gln Thr Pro Ser Ala Trp Gln Asn Pro Val Ala Trp Gln 
                 325                330                335
Asn Pro Val Ile Trp Pro Asn Pro Val Ile Trp Gln Asn Pro Val Ile 
             340                345                350
Trp Pro Asn Pro Ile Val Trp Pro Gly Pro Ile Val Trp Pro Asn Pro 
         355                360                365
Met Ala Trp Gln Ser Thr Pro Gly Trp Gln Ser Pro Pro Ser Trp Gln 
     370                375                380
Ala Pro Pro Ser Trp Gln Ser Pro Gln Asp Trp Gln Gly Pro Pro Asp 
 385                390                395                400
Trp Gln Leu Pro Pro Asp Trp Ser Met Pro Pro Asp Trp Ser Phe Pro 
                 405                410                415
Ser Asp Trp Pro Phe Pro Pro Asp Cys Ile Leu Ala Asp Trp Pro Ile 
             420                425                430
Pro Pro Asp Trp Gln Asn Leu Arg Pro Ser Pro Asn Leu Arg Ser Ser 
         435                440                445
Pro Asn Ser Arg Ala Ser Gln Asn Gln Gly Pro Pro Gln Pro Arg Asp 
     450                455                460
Val Ala Leu Leu Gln Glu Arg Ala Asn Lys Leu Val Lys Tyr Leu Met 
 465                470                475                480
Leu Lys Asp Tyr Thr Lys Val Pro Ile Lys Arg Ser Glu Met Leu Arg 
                 485                490                495
Asp Ile Ile Arg Glu Tyr Thr Asp Val Tyr Pro Glu Ile Ile Glu Arg 
             500                505                510
Ala Cys Phe Val Leu Glu Lys Lys Phe Gly Ile Gln Leu Lys Glu Ile 
         515                520                525
Asp Lys Glu Glu His Leu Tyr Ile Leu Ile Ser Thr Pro Glu Ser Leu 
     530                535                540
Ala Gly Ile Leu Gly Thr Thr Lys Asp Thr Pro Lys Leu Gly Leu Leu 
 545                550                555                560
Leu Val Ile Leu Gly Ile Ile Phe Met Asn Gly Asn Arg Ala Thr Glu 
                 565                570                575
Ala Val Leu Trp Glu Ala Leu Arg Lys Met Gly Leu Arg Pro Gly Val 
             580                585                590
Arg His Pro Leu Leu Gly Asp Leu Arg Lys Leu Leu Thr Tyr Glu Phe 
         595                600                605
Val Lys Gln Lys Tyr Leu Asp Tyr Arg Arg Val Pro Asn Ser Asn Pro 
     610                615                620
Pro Glu Tyr Glu Phe Leu Trp Gly Leu Arg Ser Tyr His Glu Thr Ser 
 625                630                635                640
Lys Met Lys Val Leu Arg Phe Ile Ala Glu Val Gln Lys Arg Asp Pro 
                 645                650                655
Arg Asp Trp Thr Ala Gln Phe Met Glu Ala Ala Asp Glu Ala Leu Asp 
             660                665                670
Ala Leu Asp Ala Ala Ala Ala Glu Ala Glu Ala Arg Ala Glu Ala Arg 
         675                680                685
Asn Arg Met Gly Leu Glu Thr Glu Leu Cys Leu Gly Pro Trp Ser Trp 
     690                695                700
Asp Asp Ile Glu Phe Glu Leu Leu Thr Trp Asp Glu Glu Gly Asp Phe 
 705                710                715                720
Gly Asp Pro Trp Ser Arg Ile Pro Phe Thr Phe Trp Ala Arg Tyr His 
                 725                730                735
Gln Asn Ala Arg Ser Arg Phe Pro Gln Ala Phe Thr Gly Pro Ile Ile 
             740                745                750
Gly Pro Ser Gly Thr Ala Thr Ala Asn Phe Ala Ala Asn Phe Gly Ala 
         755                760                765
Ile Gly Phe Phe Trp Val Glu 
     770                775



<210> 5483
<211> 5441
<212> DNA
<213> Homo sapiens
<308> AK074092
<400> 5483

ggacaagga  agagtgcgg  tgctgagag  cgagcccag  aatcccgat  ctctgagtc  60
tgaagaagg  aggcagcga  ggggttggg  ttggggcct  aggcaagcc  ccaggctcc  120
ctcttgcca  agggacagg  gccatggct  agaaaatgg  ctgtggtgc  ggcctcctc  180
gcttccagg  tgaggcctc  gtagaagac  gcgccttgc  tatgcagac  ttgatggag  240
ccatccaga  ctcagaggc  ccacctact  accaggcca  cgcagctgc  agtccccag  300
gttcacagc  cccaactgc  aatgagatg  ctgacattc  ggtttcagc  gctgccgct  360
ggcctaagt  agcctttaa  gtccagaat  ccaccacaa  aggcccaaa  ggtgtctat  420
atttctctc  ggctcataa  gccaaggat  tgcccaaca  gcagcccaa  gcagccttt  480
agtcccaaa  tgctacccc  aagggtcca  atgctgcct  tgatttttc  caggcagca  540
ccactggtg  gttagctgc  aacaagtct  agatggcct  caaggccca  aatgccact  600
ctaaagtgg  cccaaatgc  acctacaat  tctctcagt  tctcaatgc  aatgacctg  660
ccaacagca  gcctaagac  cctttcaag  cttggaatg  taccactaa  gccccaaca  720
ctgataccc  gacccagaa  gtaaatcag  ccaaaatgg  cacttccca  gctgacata  780
agaccgacc  aggtatctc  gaacctgac  gtgcaactg  acagacatc  gcagatggt  840
cccaggctc  gaatctgga  tcccggaca  taattcggg  caagaggac  cgcaagatt  900
ataacttga  tgttgaaga  aacagcagt  gggatcaga  gcgggcccc  ctggctgca  960
ggacctgga  gtctgcacc  gttccagtg  ccactcaga  cccacctgg  gcacccccc  1020
atgtgtctg  cagacgcca  tggcttggc  gaacccctc  gggctggca  aaccagaca  1080
ccaggcaga  ccaacagca  gtcagagcc  tccagctag  cagaaccca  ccagcctgg  1140
agaacccag  cgcttggca  aacccagtg  tttggccaa  cccagtaat  tggcagaac  1200
cagtgatct  gccaaaccc  attgtctgg  ccggccctg  tgtctggcc  aatccactg  1260
cctggcaga  tccacctgg  tggcagact  cacctggat  gcagacccc  ccgggctgg  1320
agggtcctc  agactggca  ggtcctcct  actggccgc  accacccga  tggccactg  1380
cacctgatt  gccacttcc  actgactgg  cactaccac  tgactggat  cccgctgat  1440
ggccaattc  acctgactg  cagaacctg  gcccctcgc  taacctgcg  ccttctccc  1500
actcgcgtg  ctcacagaa  ccaggtgct  cacagcccc  agatgtggc  cttcttcag  1560
aaagagtaa  agctgtaac  ccccagtca  ttttcccct  tcttgctct  ttctttgtc  1620
tcctctcat  tgtaattca  ccaagtttt  ttgtaaata  tttataagt  taatgattt  1680
ctttttccc  cccaggcaa  taagttggt  aagtacttg  tgcttaagg  ctacacaaa  1740
gtgcccatc  agcgctcag  tatgcatcc  gtgtcccct  cccaagctc  gcccttccc  1800
tcactccat  ctctgtcag  attcttctg  ttgtagctc  gcccttccc  tcactccat  1860
ctctgtcgg  attcttctg  ttgtatgac  cttcccctt  tatcccctc  tttccatgg  1920
tggctcttt  cacccttga  gaccttgac  gtgctaccc  cagcagggc  ggcaaaggg  1980
ctgctgctc  gtggccccc  ctcggctca  atggctccc  cctctctcc  acagaaatg  2040
tgagagata  catccgtga  tacactgat  tttatccag  aatcattga  cgtgcatgc  2100
ttgtcctag  gaagaaatt  gggattcaa  tgaaagaaa  tgacaaaga  gaacacctg  2160
atattctca  cagtacccc  gagtccctg  ctggcatac  gggaacgta  gatgggaaa  2220
aaggtggaa  atggccttt  tcagtggtg  tttttttct  ggagtttca  gtagatcag  2280
gtccagggt  cagggtcac  tagcaggtc  tgggcagag  tggggtata  ttctcccct  2340
gctgaggaa  attggggag  ctagatggg  aagctggtt  gggtctctc  tgcaaatgg  2400
tactgaaaa  atattcttt  tatattccc  taggaccaa  gacacaccc  agctcggtc  2460
cctcttggt  attctgggt  tcatcttca  gaatggcaa  cgtgccagt  agggtgagt  2520
gctggacct  cagctgggg  ttggccaca  cctgatttc  atgcttatt  tccgtccct  2580
gtctcccct  gcctcccat  gcagctgtc  tctgggagg  actacgcaa  atgggactg  2640
gtcctgggt  tgattgggc  ctctcatct  ttgcctgtt  gtgccatcc  ttggcaaca  2700
tggatggtc  caggattgc  ttaacctgg  ggtctggag  gtttggttt  gggatgttc  2760
gagcccaaa  atgtgacct  ggtggatgg  gaaacagtt  tgaactctc  gcctctttt  2820
tcatctctg  cctctgttc  ggaaagctc  ttgggcatg  taatagcct  tgattgtgg  2880
tttcctttt  ttaccttca  ggtgagaca  cccctcctt  gagatctaa  gaaacttct  2940
acctatgag  ttgtaaagc  gaagtaagt  atgcctaag  ggcttttcc  gcttcttat  3000
attctgcct  tgtgctggt  agctttaga  agcccttcc  ggctggata  aatggctca  3060
gcctgtaat  ccagtactt  gggaggctc  ggtgggcgg  tcgcttgag  ccgggagtt  3120
gagaccagc  tgggcaaca  gacgaaacc  cgtctctac  aaaaaatac  aaaattagc  3180
aggcgtggt  acatgcacc  gtggtccca  ctacttggg  ggctgaggt  ggggagaat  3240
atctgagcc  aggaagttg  ggctgcggt  ggctgtgat  atgccactg  actccaacc  3300
gggcaacag  gtgagaccc  gtctcaaaa  aaataaaag  aagcccttc  caagctcgt  3360
tcttacact  tacttgtgc  tatgtgttt  tgtgcatac  gaaacactt  tgtcctcag  3420
agtatttat  gcatatact  ctcatggtt  aattcttta  tttttattt  tttattttt  3480
gagacggag  ttcgctctt  ttgcccagg  tggagtgca  tggcgtgat  tcggctcac  3540
gcaacctct  cctcctggg  tcaagctat  ctcctgcct  agcctcttg  gtagctggg  3600
ttacaggca  gtgccacca  gcccaccta  ttttgtctt  ttagtagag  cggtgtttc  3660
ccatgttag  ctggtctcg  actcccgac  tcaggtgat  tgcctgcct  ggcctccag  3720
agtgctgag  ttacaggcg  gagcgaccg  accgggcga  ttcttttgt  tgttttttt  3780
gagactgag  ctcactctg  tgcccatgc  ggagtgcag  ggtgcaatc  tggctcgct  3840
gaacttcca  ctcccaggt  caagcaatt  ttgtgcctc  gcctcccga  taactggaa  3900
ttcaggtgc  tgccaccgt  cccggctgt  tttgtattt  tagtagaga  ggggcttca  3960
cacgttggc  aggctggtc  caaactcct  acctgaagc  atccaccca  ctctgcctc  4020
caaagtgct  ggattacag  tgtgagcca  cacacccgg  cagaatttt  ctaattttt  4080
tacttttct  agcagttgt  ttgcaagtg  agcccatcc  ccatcccca  agtagacat  4140
cccaaggct  ggccaggct  acacttttg  actgcattg  actcatttc  atggacctc  4200
gtggctcac  gacaagatt  caagaatct  gagctagag  tgaggcaga  ggagtgaaa  4260
gaaatgttg  cctttctgt  accctatac  agcctcgcc  gcatctcta  tgagtgctt  4320
gcgttctag  gcaggaatt  aaggcttga  gattaaggg  taaataccc  gatggtgtt  4380
aggaatgag  ccaaggggg  gttgctatc  gaaatctgt  aaaaaatgt  agattattt  4440
tcattagtg  actaccatt  tgcctgggt  ggtagacac  aagactgtt  tgctctttc  4500
gatacctgg  ctacagacg  gtgcccaac  gcaaccccc  ggagtatga  ttcctctgg  4560
gcctccgtt  ctaccatga  actagcaag  tgaaagtgc  gagattcat  gcagaggtt  4620
agaaaagag  ccctcgtga  tggactgca  agttcatgg  ggctgcaga  gaggccttg  4680
atgctctgg  tgctgctgc  gctgaggcc  aagcccggg  tgaagcaag  acccgcatg  4740
gaattggag  tgaggctgt  tctgggccc  ggagctggg  tgacattga  tttgagctg  4800
tgacctggg  tgaggaagg  gattttgga  atccctggt  cagaattcc  tttaccttc  4860
gggccagat  ccaccagaa  gcccgctcc  gattccctc  gacctttgc  ggtcccatt  4920
ttggtcctg  tggtacagc  agtgccaac  tcgctgcca  ctttggtgc  attggtttc  4980
tctgggttg  gtgagatgt  gggtaggta  atcactttg  attgggcag  tagggtctc  5040
gggggatat  gggtccatg  ggttgtatt  atgtgcatg  gctagaagt  ttaggaaac  5100
cattgtagg  agatgagga  agtatgggg  agcactctt  ggtatgtat  ttccttatt  5160
tttgatata  atcattgat  tttttactt  ttctttctt  tgttcacag  tattgctat  5220
aatcgcagt  gtctttccc  tgtgtgagg  tgaagcctc  gattccttc  aaacacagc  5280
atctagaga  ccacatcct  ttgactgaa  gtggcatgc  agataaatt  atttgctgt  5340
ccttgtcta  tgctttttt  ccccttgtg  gctgtcaag  tttggtatc  gaaataaac  5400
ttgaaattg  aaagtgaaa  aaaaaaaaa  aaaaaaaaa  g  5441



<210> 5484
<211> 778
<212> PRT
<213> Homo sapiens
<308> Q9Y5V3
<400> 5484

Met Ala Gln Lys Met Asp Cys Gly Ala Gly Leu Leu Gly Phe Gln Ala 
  1               5                  10                  15
Glu Ala Ser Val Glu Asp Ser Ala Leu Leu Met Gln Thr Leu Met Glu 
             20                  25                  30
Ala Ile Gln Ile Ser Glu Ala Pro Pro Thr Asn Gln Ala Thr Ala Ala 
         35                  40                  45
Ala Ser Pro Gln Ser Ser Gln Pro Pro Thr Ala Asn Glu Met Ala Asp 
     50                  55                  60
Ile Gln Val Ser Ala Ala Ala Ala Arg Pro Lys Ser Ala Phe Lys Val 
 65                  70                  75                  80
Gln Asn Ala Thr Thr Lys Gly Pro Asn Gly Val Tyr Asp Phe Ser Gln 
                 85                  90                  95
Ala His Asn Ala Lys Asp Val Pro Asn Thr Gln Pro Lys Ala Ala Phe 
             100                105                110
Lys Ser Gln Asn Ala Thr Ser Lys Gly Pro Asn Ala Ala Tyr Asp Phe 
         115                120                125
Ser Gln Ala Ala Thr Thr Gly Glu Leu Ala Ala Asn Lys Ser Glu Met 
     130                135                140
Ala Phe Lys Ala Gln Asn Ala Thr Thr Lys Val Gly Pro Asn Ala Thr 
 145                150                155                160
Tyr Asn Phe Ser Gln Ser Leu Asn Ala Asn Asp Leu Ala Asn Ser Arg 
                 165                170                175
Pro Lys Thr Pro Phe Lys Ala Trp Asn Asp Thr Thr Lys Ala Pro Thr 
             180                185                190
Ala Asp Thr Gln Thr Gln Asn Val Asn Gln Ala Lys Met Ala Thr Ser 
         195                200                205
Gln Ala Asp Ile Glu Thr Asp Pro Gly Ile Ser Glu Pro Asp Gly Ala 
     210                215                220
Thr Ala Gln Thr Ser Ala Asp Gly Ser Gln Ala Gln Asn Leu Glu Ser 
 225                230                235                240
Arg Thr Ile Ile Arg Gly Lys Arg Thr Arg Lys Ile Asn Asn Leu Asn 
                 245                250                255
Val Glu Glu Asn Ser Ser Gly Asp Gln Arg Arg Ala Pro Leu Ala Ala 
             260                265                270
Gly Thr Trp Arg Ser Ala Pro Val Pro Val Thr Thr Gln Asn Pro Pro 
         275                280                285
Gly Ala Pro Pro Asn Val Leu Trp Gln Thr Pro Leu Ala Trp Gln Asn 
     290                295                300
Pro Ser Gly Trp Gln Asn Gln Thr Ala Arg Gln Thr Pro Pro Ala Arg 
 305                310                315                320
Gln Ser Pro Pro Ala Arg Gln Thr Pro Pro Ala Trp Gln Asn Pro Val 
                 325                330                335
Ala Trp Gln Asn Pro Val Ile Trp Pro Asn Pro Val Ile Trp Gln Asn 
             340                345                350
Pro Val Ile Trp Pro Asn Pro Ile Val Trp Pro Gly Pro Val Val Trp 
         355                360                365
Pro Asn Pro Leu Ala Trp Gln Asn Pro Pro Gly Trp Gln Thr Pro Pro 
     370                375                380
Gly Trp Gln Thr Pro Pro Gly Trp Gln Gly Pro Pro Asp Trp Gln Gly 
 385                390                395                400
Pro Pro Asp Trp Pro Leu Pro Pro Asp Trp Pro Leu Pro Pro Asp Trp 
                 405                410                415
Pro Leu Pro Thr Asp Trp Pro Leu Pro Pro Asp Trp Ile Pro Ala Asp 
             420                425                430
Trp Pro Ile Pro Pro Asp Trp Gln Asn Leu Arg Pro Ser Pro Asn Leu 
         435                440                445
Arg Pro Ser Pro Asn Ser Arg Ala Ser Gln Asn Pro Gly Ala Ala Gln 
     450                455                460
Pro Arg Asp Val Ala Leu Leu Gln Glu Arg Ala Asn Lys Leu Val Lys 
 465                470                475                480
Tyr Leu Met Leu Lys Asp Tyr Thr Lys Val Pro Ile Lys Arg Ser Glu 
                 485                490                495
Met Leu Arg Asp Ile Ile Arg Glu Tyr Thr Asp Val Tyr Pro Glu Ile 
             500                505                510
Ile Glu Arg Ala Cys Phe Val Leu Glu Lys Lys Phe Gly Ile Gln Leu 
         515                520                525
Lys Glu Ile Asp Lys Glu Glu His Leu Tyr Ile Leu Ile Ser Thr Pro 
     530                535                540
Glu Ser Leu Ala Gly Ile Leu Gly Thr Thr Lys Asp Thr Pro Lys Leu 
 545                550                555                560
Gly Leu Leu Leu Val Ile Leu Gly Val Ile Phe Met Asn Gly Asn Arg 
                 565                570                575
Ala Ser Glu Ala Val Leu Trp Glu Ala Leu Arg Lys Met Gly Leu Arg 
             580                585                590
Pro Gly Val Arg His Pro Leu Leu Gly Asp Leu Arg Lys Leu Leu Thr 
         595                600                605
Tyr Glu Phe Val Lys Gln Lys Tyr Leu Asp Tyr Arg Arg Val Pro Asn 
     610                615                620
Ser Asn Pro Pro Glu Tyr Glu Phe Leu Trp Gly Leu Arg Ser Tyr His 
 625                630                635                640
Glu Thr Ser Lys Met Lys Val Leu Arg Phe Ile Ala Glu Val Gln Lys 
                 645                650                655
Arg Asp Pro Arg Asp Trp Thr Ala Gln Phe Met Glu Ala Ala Asp Glu 
             660                665                670
Ala Leu Asp Ala Leu Asp Ala Ala Ala Ala Glu Ala Glu Ala Arg Ala 
         675                680                685
Glu Ala Arg Thr Arg Met Gly Ile Gly Asp Glu Ala Val Ser Gly Pro 
     690                695                700
Trp Ser Trp Asp Asp Ile Glu Phe Glu Leu Leu Thr Trp Asp Glu Glu 
 705                710                715                720
Gly Asp Phe Gly Asp Pro Trp Ser Arg Ile Pro Phe Thr Phe Trp Ala 
                 725                730                735
Arg Tyr His Gln Asn Ala Arg Ser Arg Phe Pro Gln Thr Phe Ala Gly 
             740                745                750
Pro Ile Ile Gly Pro Gly Gly Thr Ala Ser Ala Asn Phe Ala Ala Asn 
         755                760                765
Phe Gly Ala Ile Gly Phe Phe Trp Val Glu 
     770                775



<210> 5485
<211> 482
<212> DNA
<213> Rattus norvegicus
<308> AA891677
<400> 5485

aaataaaaa  tataattta  acaagactt  gtatctaaa  aagggtttc  ttttaaaaa  60
aagtgacag  ggaattttt  cctatcttc  gttctttat  gaatatgat  cttttgtag  120
acaaaagtt  caccagtga  aattattta  agatcccaa  cagactcaa  ctttacaca  180
acagaattg  acattctag  tcagtgatt  gtcagcaat  aaacacctg  ccagatcac  240
cagttcagt  caaacccca  tgtctctgt  actatgact  gaggcggcc  aggcccctg  300
cccagccct  tccccctga  ctccaccca  agacctgct  gtggccaat  gtggaacta  360
cagttgaac  tggggctgc  accgtcacc  ccctgaccc  ctgccctgg  ctaaggtca  420
tcttcatct  tctttccca  agaaagaga  tcaaactaa  ccacttact  caccccgaa  480
gc  482



<210> 5486
<211> 421
<212> DNA
<213> Rattus norvegicus
<308> AA891689
<400> 5486

caggaaaaa  gcattttat  cacatataa  cgaagcccc  gggtctgct  ggggggggg  60
ggggctgca  ggagtctca  ttggcttcc  atggtctct  ctgagatgt  agcttccag  120
tgtgccctc  caccctctg  gatgaatac  cagtagatt  cataggtgg  ctcatgact  180
tccctgtat  ggtccagat  gcgtagggg  tgctggtgg  ggaagcgct  ctgcttggg  240
tggtaaggg  gtggccgta  aaattcaaa  acaggttcc  gcatgtcta  aagctggtg  300
aaggtgtgg  tgaccgagt  atcccagcg  cactggaag  aagccagac  agctggagt  360
atggcttcc  ggtgtttct  gtacaaatc  acggtgtgg  aggtcctct  ggccagctg  420
t  421



<210> 5487
<211> 469
<212> DNA
<213> Homo sapiens
<308> BM714938
<400> 5487

cgaggacac  cgtccctca  cctgctacc  gctggccca  aggaccttc  acacccttg  60
tttctacaa  aaacaccag  aagccatga  tccagctgg  ctggctttc  tccagtgcc  120
ctgggatga  tcggtcacc  acaccttcc  ccagcttct  gacatgcgg  aacctgtgt  180
tgaatttgt  cggccaccc  cttaccacc  caaacagaa  cgcttcccc  accagcagc  240
cctacgcta  ctggaccga  acagggaca  tcatgagcc  acctatgga  tctactgag  300
attcatcga  gagggtgag  gggcacagc  ggaagctca  atctcagga  agaccatcg  360
aagccaact  agactccct  cagcccccc  cccccccag  agacccagg  gcttcggtt  420
tatgtgaat  aaatgcttt  ttcctgaaa  aaaaaaaaa  aaaaaagac  469



<210> 5488
<211> 174
<212> PRT
<213> Homo sapiens
<308> AAF28940
<400> 5488

Glu Ala Glu Glu Gly Ser Leu Trp Thr Leu Leu Leu Thr Ser Leu Asp 
  1               5                  10                  15
Gly His Leu Leu Glu Pro Asp Ala Glu Tyr Leu His Trp Leu Leu Thr 
             20                  25                  30
Asn Ile Pro Gly Asn Arg Val Ala Glu Gly Gln Val Thr Cys Pro Tyr 
         35                  40                  45
Leu Pro Pro Phe Pro Ala Arg Gly Ser Gly Ile His Arg Leu Ala Phe 
     50                  55                  60
Leu Leu Phe Lys Gln Asp Gln Pro Ile Asp Phe Ser Glu Asp Ala Arg 
 65                  70                  75                  80
Pro Ser Pro Cys Tyr Gln Leu Ala Gln Arg Thr Phe Arg Thr Phe Asp 
                 85                  90                  95
Phe Tyr Lys Lys His Gln Glu Thr Met Thr Pro Ala Gly Leu Ser Phe 
             100                105                110
Phe Gln Cys Arg Trp Asp Asp Ser Val Thr Tyr Ile Phe His Gln Leu 
         115                120                125
Leu Asp Met Arg Glu Pro Val Phe Glu Phe Val Arg Pro Pro Pro Tyr 
     130                135                140
His Pro Lys Gln Lys Arg Phe Pro His Arg Gln Pro Leu Arg Tyr Leu 
 145                150                155                160
Asp Arg Tyr Arg Asp Ser His Glu Pro Thr Tyr Gly Ile Tyr 
                 165                170



<210> 5489
<211> 493
<212> DNA
<213> Rattus norvegicus
<308> AA891694
<400> 5489

gcaaatgtg  aaccacttt  acttggttt  tcaagtagt  gaataggat  agaccattt  60
cacctgaga  gaggcactt  tatgattcc  cccaaaaag  ataagtata  actacaact  120
ttcttgtta  tcgtattct  catttcagg  gtgattaac  tcaagatgg  ttacaggta  180
tataaactt  tattttgtt  tcttccatt  gttccgagt  aacaaactc  gtgaaatac  240
taaaataca  ccgcaacac  gaccagtta  tgtactcac  tacaaatga  ctgaacatc  300
cgtaaggac  caagtttca  aaaaggagt  cttcaacac  acttcaaca  cgacgatag  360
tttttcata  ttatgtata  atacattag  atccaaagg  cgaatctct  tactatttc  420
agataagaa  gtcctcaaa  gtgtaactg  attacaaat  atagtctta  atatgcttt  480
aaagtaatc  agt  493



<210> 5490
<211> 470
<212> DNA
<213> Rattus norvegicus
<308> AA891700
<400> 5490

aaaaacaaa  acacattta  tttgtcctt  attttttgg  gcaacttat  cacaaacat  60
acatcagtt  gtctgtact  ttaaaaata  taaatcaac  atatgtaca  tcaaattta  120
aaccaaaag  aaatgaacc  gtcggtgcg  tatgactgc  acccagtgg  ccagctgag  180
tcctccagg  cctgagccg  gcacaagag  ggcccctgt  atcttcact  cagacagaa  240
atcttcagt  ccgagactt  aggtgcaaa  atgtcgatt  tgcagctac  acacaagca  300
actttagag  gcgagaaca  attctcccc  cacatccaa  aattataat  aatagagat  360
taattccaa  tgcatatgc  attcaatca  cattagagg  agtcaggcg  ccaggacct  420
tagcctaag  cgtctccat  ccacacttc  ctccgctct  gtcgtgtctg  470



<210> 5491
<211> 5107
<212> DNA
<213> Homo sapiens
<308> U19252
<400> 5491

gcggcgcaa  cggctccgg  gctgcctgg  gcggccggg  gggcggcgc  gctcaggct  60
gggctccgg  tgggcccgg  gcggcctcg  ggctgccca  ggggcgcgg  gggccgggc  120
ggtgacgcc  gacgcccat  gacgcctct  aggagccgc  gccgccggt  atctacacc  180
tggagaaca  gcccatcgt  acctgtgct  gagatcaga  tttatttac  tctgtttat  240
caacgctct  tcagcagct  ccaagagaa  caatggaat  gagaaggtc  tatggccgg  300
ctccgaaga  gattcacct  gagtctaac  ttgttcaat  caaagagga  ctgctgccc  360
aagaaggaa  caaagctct  ctcacgttt  ccttcctcc  tatttactg  acagagtgc  420
gtgataccg  agtgtataa  gctacagta  aagatgacc  caccaagtg  cagaatgtt  480
tgaaggctc  tagctctgt  gactggtta  tagtgatag  tgaaaatga  gccaagaaa  540
aaaacaaaa  caacatcct  ccccgaacc  ctattgtgg  caaaataag  aatgatttt  600
gtaataaac  gagtgacag  tgtgttgtg  tctccgacc  cttgaagga  tcttctcga  660
ctcaggaat  ctggaatgc  ttcctgacc  aactcagga  attgcttct  atgtctttt  720
ccaaaaacc  aggcaagtt  gaggatgac  tgagaacct  gagggagaa  aggactgag  780
caggctgga  cttttgtga  tatttcatg  ttcaggagg  gcttgcctt  gttttcgag  840
tgctgcagc  gttcgagga  gccctggtg  agtacgacg  actggacgc  ctcttctct  900
agtatgtgg  caacttcgg  gccggggat  gtgccaact  gctgacttt  ttctgccag  960
cagtgaaga  ctggaacgg  ttgatcctc  gaaaaccca  agatatgga  aagcgggaa  1020
cgatccaga  gcgagaagc  accctgtta  atctgcgca  ttacctgtt  tctcgccag  1080
gcaccttgc  gctcttcct  cagaggccg  gggaggtgg  ccagcgcgc  ctagagctg  1140
tgcacaact  cgtgcagga  ctgaagctc  tagaagtct  tgtcccacc  ggtgctctg  1200
actgctggg  gtttctgag  tgtctggag  tgttgcaga  gatagaagg  tgctgtgac  1260
gggcacaga  cgactcaaa  attgcccac  ctgtggggc  atggagcta  gccacagaa  1320
agttaaagt  cttgggcta  ctatgtgga  ttgtgtcag  gaaaggacc  aactcagaa  1380
atctcaaca  gacagttga  cttttggca  gtttgggag  tgagcgacc  gaaacagcc  1440
acacagctc  gagtcctta  aagaaactg  aagaagcat  atcgtcagt  gaagctttt  1500
aaaaacact  cttagattt  tcccatgcc  ccattgaaa  gtatacaag  attgggagg  1560
ttcgatctg  taagtttgt  ggaaaagat  tggcagagt  ttacatgag  aaaaaggct  1620
cacaaaagg  agaaatcta  cttcaagga  cactgaaaa  ctacctggc  gagggctgg  1680
cactcccca  cacacacac  aggaagcag  tggccgaat  tcaaaagca  cttggacaa  1740
ttgaaaact  cctgcagac  agcagcctc  tagccagtg  ccaccacct  actgaagag  1800
agcgcaagc  cttctgcca  gagatactt  actttgcca  ccagccgtc  gacagccca  1860
gtcataaga  agtgctacc  atgcattcc  ttgcacaac  gcgagatct  cattttgat  1920
cctccaatg  cgtggtcca  gtgggcggc  ttttgtgcg  tgagataac  atgtacagc  1980
agatgcctg  gcctgttca  gtggagcag  ttgtggtca  tgtccactt  agcattgag  2040
aaaacagct  ccggaagac  gcggagtgg  ttaccaagc  caagacgtc  aatgggatc  2100
ttaactttc  acccgagac  gcacctttc  ctgtatccc  aaacagttt  cccgcgctg  2160
agttgtatg  aatgtttga  agaagccca  ctgataact  cttgaacac  actgggatt  2220
tctgcagaa  cgtccacat  ctcctgaga  ggcaggaga  cagctcctc  ctagagatg  2280
cctcagggg  ggctctgga  gagggtgcc  acgtgctga  gtgcagcca  gtgaccctg  2340
aaccagggg  caaccagat  acattcagg  ctcaggcca  ggaacctgg  acgtataca  2400
tcaggcagc  gtgcgcctc  gtgggctcc  tgtggttcg  cctccctca  atctacccc  2460
ttgtgcagt  cgacgtgta  tcacaggag  cccagctgc  cgtggagcc  ctggctgat  2520
gccttctgg  aggcattcc  cagagagtc  agttcactg  cactaccgg  catgatacg  2580
taaagaatg  agacagcct  cagcttagc  atgccgaag  catgctcat  ctgtgccag  2640
cggagagca  ggctgtggt  tactccaac  cgagagaac  gtcttctga  gccgcgctc  2700
ggattcagt  ctccgacaa  gtcacgagc  tcagtctgc  tgttgcgcc  gcgtaccac  2760
tgatcgaat  tgaactgga  gttctctct  taccttcag  cccagcact  ggaggggag  2820
gtgacatgc  ggggatggc  gagccccac  ggaagcata  ggacaaaca  agaactggc  2880
gctgcatgg  taccacaga  cacaaagtg  cgattgact  cccgtggtc  atctactcc  2940
cagtcatcg  actgacctt  agcgtaccc  tcaggacca  acacagcct  ctgtcctca  3000
gaacacgga  atatgttca  gtttgtgtc  agaatttgt  agaacttga  tttcagctg  3060
cagatagtt  tcttgtaga  accggtgat  gtaccgacc  gcaactagt  ccactgaac  3120
cgcagtccc  gcagcccat  tacagcaag  agtcggtgt  cttcgtctg  gaactcaag  3180
ggacagaag  gcctccccc  tctctgcat  gccggttct  tgttggatt  tccccagct  3240
ctgaggaac  gctgtctat  tccttaaag  cgtatactt  tgaatttaa  gtggaaaat  3300
tttttacat  atacaacgt  aaggctgag  tctttcccc  ttcgggaat  gagtattgc  3360
gaacaggct  cctctgctc  ctggaggtt  tgatcacga  gctctcaga  ctcttggag  3420
tggataaag  tgaagcact  actgaatct  atgagcatt  ttcgacaaa  cttatgtat  3480
aagttgtcg  caacagtag  aactgggca  tgtgtggga  aagctgcgg  gtcatctcc  3540
tgccagtgg  tgctcgggc  actcacagg  tccacatgg  agtgatgcc  ctcttcgcc  3600
ggtatctcc  cctgcccga  gtcaggctg  tcaagtacc  cccccatca  tctgcacac  3660
cctcccaac  ggacgctga  agctggata  aaaacgcag  ctgtcagta  acaagcacg  3720
ggacgacca  ccggacagc  gcagcctca  gagcagggg  agcgtgcat  cggcctgca  3780
cagcgagca  aaaggccta  ccatgcccc  gctgcaggc  ctgccggcc  gccaggtct  3840
caactccag  tcgggcaca  aagtcctgg  catccccag  caagatgac  acgtcctgg  3900
agtcagtgt  acatgacaa  gccagggtg  acacacgcc  cttcccagc  aggagtgca  3960
tttatggga  tgtgactgg  ctcttccgt  ctggctcca  ccagacctt  agtggtcct  4020
cctggccgt  gggacatca  agagtgtca  cacgcagct  gccagctga  ttctgttgt  4080
gttttcatg  cgcctgtga  ctcagattc  tgcttttct  accccgtcc  catgctggt  4140
tccgacgcc  cttactcag  gccctggcc  ccctccccc  acctcacac  ctgctcatg  4200
aagtttcca  ccacgctgt  tccacggaa  agcctccgt  tgctggctc  tcgtggaag  4260
ccatttgtc  ttcaggtag  cactcagca  ccctcacgg  cttagtgac  tgtgtgcct  4320
tctggtcac  cagctgccc  gtttcctga  cggggtgga  ttgtgtccc  taaggggta  4380
aacagccgt  taccgcaga  cctctcata  acccttcta  gggaggcgg  tgggggagg  4440
agggatcat  accccttct  tgccttggg  tgccggagc  gggggacct  gaggcccat  4500
agccggagc  acgtgaaag  tactgaaga  agctgagac  cggctgtga  gagcgcctc  4560
gcggtgagg  ggtttaggg  taaatgttt  tggaaccct  tggtccccc  taatgttga  4620
agatatcat  tgcactggg  gttaaatat  tttaattta  tgatcatta  atatgtggg  4680
gttaatatg  tgtttttct  tccctttaa  gtctttaca  gtaattgta  ctgtataat  4740
gttattttt  ttttgcatc  taagtctta  aaattaaga  attccatcg  gaggatgag  4800
gaggtcctc  gtgtgtttt  ggtctggtt  tagggaagg  ctcaagtcc  ggaatgtcc  4860
ccactggtc  actgagttg  agtcacact  ttccaatgg  ttatttgct  tcggttgta  4920
atttaattg  acatatggt  gatttatta  ttttaaaaa  acagactaa  tgatgtaat  4980
tttatgtat  agttgcacc  aaaatcaag  acaaaaata  gtgtgtttg  ttttacagg  5040
gtgaaagtc  cagcttgta  ataagtgtt  tatgtatta  accttttcc  gttctccaa  5100
gcgatgt  5107



<210> 5492
<211> 1259
<212> PRT
<213> Homo sapiens
<308> P48553
<400> 5492

Met Asp Ala Ser Glu Glu Pro Leu Pro Pro Val Ile Tyr Thr Met Glu 
  1               5                  10                  15
Asn Lys Pro Ile Val Thr Cys Ala Gly Asp Gln Asn Leu Phe Thr Ser 
             20                  25                  30
Val Tyr Pro Thr Leu Ser Gln Gln Leu Pro Arg Glu Pro Met Glu Trp 
         35                  40                  45
Arg Arg Ser Tyr Gly Arg Ala Pro Lys Met Ile His Leu Glu Ser Asn 
     50                  55                  60
Phe Val Gln Phe Lys Glu Glu Leu Leu Pro Lys Glu Gly Asn Lys Ala 
 65                  70                  75                  80
Leu Leu Thr Phe Pro Phe Leu His Ile Tyr Trp Thr Glu Cys Cys Asp 
                 85                  90                  95
Thr Glu Val Tyr Lys Ala Thr Val Lys Asp Asp Leu Thr Lys Trp Gln 
             100                105                110
Asn Val Leu Lys Ala His Ser Ser Val Asp Trp Leu Ile Val Ile Val 
         115                120                125
Glu Asn Asp Ala Lys Lys Lys Asn Lys Thr Asn Ile Leu Pro Arg Thr 
     130                135                140
Ser Ile Val Asp Lys Ile Arg Asn Asp Phe Cys Asn Lys Gln Ser Asp 
 145                150                155                160
Arg Cys Val Val Leu Ser Asp Pro Leu Lys Asp Ser Ser Arg Thr Gln 
                 165                170                175
Glu Ser Trp Asn Ala Phe Leu Thr Lys Leu Arg Thr Leu Leu Leu Met 
             180                185                190
Ser Phe Thr Lys Asn Leu Gly Lys Phe Glu Asp Asp Met Arg Thr Leu 
         195                200                205
Arg Glu Lys Arg Thr Glu Pro Gly Trp Ser Phe Cys Glu Tyr Phe Met 
     210                215                220
Val Gln Glu Glu Leu Ala Phe Val Phe Glu Met Leu Gln Gln Phe Glu 
 225                230                235                240
Asp Ala Leu Val Gln Tyr Asp Glu Leu Asp Ala Leu Phe Ser Gln Tyr 
                 245                250                255
Val Val Asn Phe Gly Ala Gly Asp Gly Ala Asn Trp Leu Thr Phe Phe 
             260                265                270
Cys Gln Pro Val Lys Ser Trp Asn Gly Leu Ile Leu Arg Lys Pro Ile 
         275                280                285
Asp Met Glu Lys Arg Glu Ser Ile Gln Arg Arg Glu Ala Thr Leu Leu 
     290                295                300
Asp Leu Arg Ser Tyr Leu Phe Ser Arg Gln Cys Thr Leu Leu Leu Phe 
 305                310                315                320
Leu Gln Arg Pro Trp Glu Val Ala Gln Arg Ala Leu Glu Leu Leu His 
                 325                330                335
Asn Cys Val Gln Glu Leu Lys Leu Leu Glu Val Ser Val Pro Pro Gly 
             340                345                350
Ala Leu Asp Cys Trp Val Phe Leu Ser Cys Leu Glu Val Leu Gln Arg 
         355                360                365
Ile Glu Gly Cys Cys Asp Arg Ala Gln Ile Asp Ser Asn Ile Ala His 
     370                375                380
Thr Val Gly Leu Trp Ser Tyr Ala Thr Glu Lys Leu Lys Ser Leu Gly 
 385                390                395                400
Tyr Leu Cys Gly Leu Val Ser Glu Lys Gly Pro Asn Ser Glu Asp Leu 
                 405                410                415
Asn Arg Thr Val Asp Leu Leu Ala Gly Leu Gly Ala Glu Arg Pro Glu 
             420                425                430
Thr Ala Asn Thr Ala Gln Ser Pro Tyr Lys Lys Leu Lys Glu Ala Leu 
         435                440                445
Ser Ser Val Glu Ala Phe Glu Lys His Tyr Leu Asp Leu Ser His Ala 
     450                455                460
Thr Ile Glu Met Tyr Thr Ser Ile Gly Arg Ile Arg Ser Ala Lys Phe 
 465                470                475                480
Val Gly Lys Asp Leu Ala Glu Phe Tyr Met Arg Lys Lys Ala Pro Gln 
                 485                490                495
Lys Ala Glu Ile Tyr Leu Gln Gly Ala Leu Lys Asn Tyr Leu Ala Glu 
             500                505                510
Gly Trp Ala Leu Pro Ile Thr His Thr Arg Lys Gln Leu Ala Glu Cys 
         515                520                525
Gln Lys His Leu Gly Gln Ile Glu Asn Tyr Leu Gln Thr Ser Ser Leu 
     530                535                540
Leu Ala Ser Asp His His Leu Thr Glu Glu Glu Arg Lys His Phe Cys 
 545                550                555                560
Gln Glu Ile Leu Asp Phe Ala Ser Gln Pro Ser Asp Ser Pro Gly His 
                 565                570                575
Lys Ile Val Leu Pro Met His Ser Phe Ala Gln Leu Arg Asp Leu His 
             580                585                590
Phe Asp Pro Ser Asn Ala Val Val His Val Gly Gly Val Leu Cys Val 
         595                600                605
Glu Ile Thr Met Tyr Ser Gln Met Pro Val Pro Val His Val Glu Gln 
     610                615                620
Ile Val Val Asn Val His Phe Ser Ile Glu Lys Asn Ser Tyr Arg Lys 
 625                630                635                640
Thr Ala Glu Trp Leu Thr Lys His Lys Thr Ser Asn Gly Ile Ile Asn 
                 645                650                655
Phe Pro Pro Glu Thr Ala Pro Phe Pro Val Ser Gln Asn Ser Leu Pro 
             660                665                670
Ala Leu Glu Leu Tyr Glu Met Phe Glu Arg Ser Pro Ser Asp Asn Ser 
         675                680                685
Leu Asn Thr Thr Gly Ile Ile Cys Arg Asn Val His Met Leu Leu Arg 
     690                695                700
Arg Gln Glu Ser Ser Ser Ser Leu Glu Met Pro Ser Gly Val Ala Leu 
 705                710                715                720
Glu Glu Gly Ala His Val Leu Arg Cys Ser His Val Thr Leu Glu Pro 
                 725                730                735
Gly Ala Asn Gln Ile Thr Phe Arg Thr Gln Ala Lys Glu Pro Gly Thr 
             740                745                750
Tyr Thr Leu Arg Gln Leu Cys Ala Ser Val Gly Ser Val Trp Phe Val 
         755                760                765
Leu Pro His Ile Tyr Pro Ile Val Gln Tyr Asp Val Tyr Ser Gln Glu 
     770                775                780
Pro Gln Leu His Val Glu Pro Leu Ala Asp Ser Leu Leu Ala Gly Ile 
 785                790                795                800
Pro Gln Arg Val Lys Phe Thr Val Thr Thr Gly His Tyr Thr Ile Lys 
                 805                810                815
Asn Gly Asp Ser Leu Gln Leu Ser Asn Ala Glu Ala Met Leu Ile Leu 
             820                825                830
Cys Gln Ala Glu Ser Arg Ala Val Val Tyr Ser Asn Thr Arg Glu Gln 
         835                840                845
Ser Ser Glu Ala Ala Leu Arg Ile Gln Ser Ser Asp Lys Val Thr Ser 
     850                855                860
Ile Ser Leu Pro Val Ala Pro Ala Tyr His Val Ile Glu Phe Glu Leu 
 865                870                875                880
Glu Val Leu Ser Leu Pro Ser Ala Pro Ala Leu Gly Gly Glu Ser Asp 
                 885                890                895
Met Leu Gly Met Ala Glu Pro His Arg Lys His Lys Asp Lys Gln Arg 
             900                905                910
Thr Gly Arg Cys Met Val Thr Thr Asp His Lys Val Ser Ile Asp Cys 
         915                920                925
Pro Trp Ser Ile Tyr Ser Thr Val Ile Ala Leu Thr Phe Ser Val Pro 
     930                935                940
Phe Arg Thr Thr His Ser Leu Leu Ser Ser Gly Thr Arg Lys Tyr Val 
 945                950                955                960
Gln Val Cys Val Gln Asn Leu Ser Glu Leu Asp Phe Gln Leu Ser Asp 
                 965                970                975
Ser Tyr Leu Val Asp Thr Gly Asp Ser Thr Asp Leu Gln Leu Val Pro 
             980                985                990
Leu Asn Thr Gln Ser Gln Gln Pro Ile Tyr Ser Lys Gln Ser Val Phe 
         995                1000                1005
Phe Val Trp Glu Leu Lys Trp Thr Glu Glu Pro Pro Pro Ser Leu His 
     1010                1015                1020
Cys Arg Phe Ser Val Gly Phe Ser Pro Ala Ser Glu Glu Gln Leu Ser 
 1025                1030                1035                1040
Ile Ser Leu Lys Pro Tyr Thr Tyr Glu Phe Lys Val Glu Asn Phe Phe 
                 1045                1050                1055
Thr Leu Tyr Asn Val Lys Ala Glu Ile Phe Pro Pro Ser Gly Met Glu 
             1060                1065                1070
Tyr Cys Arg Thr Gly Ser Leu Cys Ser Leu Glu Val Leu Ile Thr Arg 
         1075                1080                1085
Leu Ser Asp Leu Leu Glu Val Asp Lys Asp Glu Ala Leu Thr Glu Ser 
     1090                1095                1100
Asp Glu His Phe Ser Thr Lys Leu Met Tyr Glu Val Val Asp Asn Ser 
 1105                1110                1115                1120
Ser Asn Trp Ala Val Cys Gly Lys Ser Cys Gly Val Ile Ser Met Pro 
                 1125                1130                1135
Val Ala Ala Arg Ala Thr His Arg Val His Met Glu Val Met Pro Leu 
             1140                1145                1150
Phe Ala Gly Tyr Leu Pro Leu Pro Asp Val Arg Leu Phe Lys Tyr Leu 
         1155                1160                1165
Pro His His Ser Ala His Ser Ser Gln Leu Asp Ala Asp Ser Trp Ile 
     1170                1175                1180
Glu Asn Asp Ser Leu Ser Val Asp Lys His Gly Asp Asp Gln Pro Asp 
 1185                1190                1195                1200
Ser Ser Ser Leu Lys Ser Arg Gly Ser Val His Ser Ala Cys Ser Ser 
                 1205                1210                1215
Glu His Lys Gly Leu Pro Met Pro Arg Leu Gln Ala Leu Pro Ala Gly 
             1220                1225                1230
Gln Val Phe Asn Ser Ser Ser Gly Thr Gln Val Leu Val Ile Pro Ser 
         1235                1240                1245
Gln Asp Asp His Val Leu Glu Val Ser Val Thr 
     1250                1255



<210> 5493
<211> 470
<212> DNA
<213> Rattus norvegicus
<308> AA891700
<400> 5493

aaaaacaaa  acacattta  tttgtcctt  attttttgg  gcaacttat  cacaaacat  60
acatcagtt  gtctgtact  ttaaaaata  taaatcaac  atatgtaca  tcaaattta  120
aaccaaaag  aaatgaacc  gtcggtgcg  tatgactgc  acccagtgg  ccagctgag  180
tcctccagg  cctgagccg  gcacaagag  ggcccctgt  atcttcact  cagacagaa  240
atcttcagt  ccgagactt  aggtgcaaa  atgtcgatt  tgcagctac  acacaagca  300
actttagag  gcgagaaca  attctcccc  cacatccaa  aattataat  aatagagat  360
taattccaa  tgcatatgc  attcaatca  cattagagg  agtcaggcg  ccaggacct  420
tagcctaag  cgtctccat  ccacacttc  ctccgctct  gtcgtgtctg  470



<210> 5494
<211> 5107
<212> DNA
<213> Homo sapiens
<308> U19252
<400> 5494

gcggcgcaa  cggctccgg  gctgcctgg  gcggccggg  gggcggcgc  gctcaggct  60
gggctccgg  tgggcccgg  gcggcctcg  ggctgccca  ggggcgcgg  gggccgggc  120
ggtgacgcc  gacgcccat  gacgcctct  aggagccgc  gccgccggt  atctacacc  180
tggagaaca  gcccatcgt  acctgtgct  gagatcaga  tttatttac  tctgtttat  240
caacgctct  tcagcagct  ccaagagaa  caatggaat  gagaaggtc  tatggccgg  300
ctccgaaga  gattcacct  gagtctaac  ttgttcaat  caaagagga  ctgctgccc  360
aagaaggaa  caaagctct  ctcacgttt  ccttcctcc  tatttactg  acagagtgc  420
gtgataccg  agtgtataa  gctacagta  aagatgacc  caccaagtg  cagaatgtt  480
tgaaggctc  tagctctgt  gactggtta  tagtgatag  tgaaaatga  gccaagaaa  540
aaaacaaaa  caacatcct  ccccgaacc  ctattgtgg  caaaataag  aatgatttt  600
gtaataaac  gagtgacag  tgtgttgtg  tctccgacc  cttgaagga  tcttctcga  660
ctcaggaat  ctggaatgc  ttcctgacc  aactcagga  attgcttct  atgtctttt  720
ccaaaaacc  aggcaagtt  gaggatgac  tgagaacct  gagggagaa  aggactgag  780
caggctgga  cttttgtga  tatttcatg  ttcaggagg  gcttgcctt  gttttcgag  840
tgctgcagc  gttcgagga  gccctggtg  agtacgacg  actggacgc  ctcttctct  900
agtatgtgg  caacttcgg  gccggggat  gtgccaact  gctgacttt  ttctgccag  960
cagtgaaga  ctggaacgg  ttgatcctc  gaaaaccca  agatatgga  aagcgggaa  1020
cgatccaga  gcgagaagc  accctgtta  atctgcgca  ttacctgtt  tctcgccag  1080
gcaccttgc  gctcttcct  cagaggccg  gggaggtgg  ccagcgcgc  ctagagctg  1140
tgcacaact  cgtgcagga  ctgaagctc  tagaagtct  tgtcccacc  ggtgctctg  1200
actgctggg  gtttctgag  tgtctggag  tgttgcaga  gatagaagg  tgctgtgac  1260
gggcacaga  cgactcaaa  attgcccac  ctgtggggc  atggagcta  gccacagaa  1320
agttaaagt  cttgggcta  ctatgtgga  ttgtgtcag  gaaaggacc  aactcagaa  1380
atctcaaca  gacagttga  cttttggca  gtttgggag  tgagcgacc  gaaacagcc  1440
acacagctc  gagtcctta  aagaaactg  aagaagcat  atcgtcagt  gaagctttt  1500
aaaaacact  cttagattt  tcccatgcc  ccattgaaa  gtatacaag  attgggagg  1560
ttcgatctg  taagtttgt  ggaaaagat  tggcagagt  ttacatgag  aaaaaggct  1620
cacaaaagg  agaaatcta  cttcaagga  cactgaaaa  ctacctggc  gagggctgg  1680
cactcccca  cacacacac  aggaagcag  tggccgaat  tcaaaagca  cttggacaa  1740
ttgaaaact  cctgcagac  agcagcctc  tagccagtg  ccaccacct  actgaagag  1800
agcgcaagc  cttctgcca  gagatactt  actttgcca  ccagccgtc  gacagccca  1860
gtcataaga  agtgctacc  atgcattcc  ttgcacaac  gcgagatct  cattttgat  1920
cctccaatg  cgtggtcca  gtgggcggc  ttttgtgcg  tgagataac  atgtacagc  1980
agatgcctg  gcctgttca  gtggagcag  ttgtggtca  tgtccactt  agcattgag  2040
aaaacagct  ccggaagac  gcggagtgg  ttaccaagc  caagacgtc  aatgggatc  2100
ttaactttc  acccgagac  gcacctttc  ctgtatccc  aaacagttt  cccgcgctg  2160
agttgtatg  aatgtttga  agaagccca  ctgataact  cttgaacac  actgggatt  2220
tctgcagaa  cgtccacat  ctcctgaga  ggcaggaga  cagctcctc  ctagagatg  2280
cctcagggg  ggctctgga  gagggtgcc  acgtgctga  gtgcagcca  gtgaccctg  2340
aaccagggg  caaccagat  acattcagg  ctcaggcca  ggaacctgg  acgtataca  2400
tcaggcagc  gtgcgcctc  gtgggctcc  tgtggttcg  cctccctca  atctacccc  2460
ttgtgcagt  cgacgtgta  tcacaggag  cccagctgc  cgtggagcc  ctggctgat  2520
gccttctgg  aggcattcc  cagagagtc  agttcactg  cactaccgg  catgatacg  2580
taaagaatg  agacagcct  cagcttagc  atgccgaag  catgctcat  ctgtgccag  2640
cggagagca  ggctgtggt  tactccaac  cgagagaac  gtcttctga  gccgcgctc  2700
ggattcagt  ctccgacaa  gtcacgagc  tcagtctgc  tgttgcgcc  gcgtaccac  2760
tgatcgaat  tgaactgga  gttctctct  taccttcag  cccagcact  ggaggggag  2820
gtgacatgc  ggggatggc  gagccccac  ggaagcata  ggacaaaca  agaactggc  2880
gctgcatgg  taccacaga  cacaaagtg  cgattgact  cccgtggtc  atctactcc  2940
cagtcatcg  actgacctt  agcgtaccc  tcaggacca  acacagcct  ctgtcctca  3000
gaacacgga  atatgttca  gtttgtgtc  agaatttgt  agaacttga  tttcagctg  3060
cagatagtt  tcttgtaga  accggtgat  gtaccgacc  gcaactagt  ccactgaac  3120
cgcagtccc  gcagcccat  tacagcaag  agtcggtgt  cttcgtctg  gaactcaag  3180
ggacagaag  gcctccccc  tctctgcat  gccggttct  tgttggatt  tccccagct  3240
ctgaggaac  gctgtctat  tccttaaag  cgtatactt  tgaatttaa  gtggaaaat  3300
tttttacat  atacaacgt  aaggctgag  tctttcccc  ttcgggaat  gagtattgc  3360
gaacaggct  cctctgctc  ctggaggtt  tgatcacga  gctctcaga  ctcttggag  3420
tggataaag  tgaagcact  actgaatct  atgagcatt  ttcgacaaa  cttatgtat  3480
aagttgtcg  caacagtag  aactgggca  tgtgtggga  aagctgcgg  gtcatctcc  3540
tgccagtgg  tgctcgggc  actcacagg  tccacatgg  agtgatgcc  ctcttcgcc  3600
ggtatctcc  cctgcccga  gtcaggctg  tcaagtacc  cccccatca  tctgcacac  3660
cctcccaac  ggacgctga  agctggata  aaaacgcag  ctgtcagta  acaagcacg  3720
ggacgacca  ccggacagc  gcagcctca  gagcagggg  agcgtgcat  cggcctgca  3780
cagcgagca  aaaggccta  ccatgcccc  gctgcaggc  ctgccggcc  gccaggtct  3840
caactccag  tcgggcaca  aagtcctgg  catccccag  caagatgac  acgtcctgg  3900
agtcagtgt  acatgacaa  gccagggtg  acacacgcc  cttcccagc  aggagtgca  3960
tttatggga  tgtgactgg  ctcttccgt  ctggctcca  ccagacctt  agtggtcct  4020
cctggccgt  gggacatca  agagtgtca  cacgcagct  gccagctga  ttctgttgt  4080
gttttcatg  cgcctgtga  ctcagattc  tgcttttct  accccgtcc  catgctggt  4140
tccgacgcc  cttactcag  gccctggcc  ccctccccc  acctcacac  ctgctcatg  4200
aagtttcca  ccacgctgt  tccacggaa  agcctccgt  tgctggctc  tcgtggaag  4260
ccatttgtc  ttcaggtag  cactcagca  ccctcacgg  cttagtgac  tgtgtgcct  4320
tctggtcac  cagctgccc  gtttcctga  cggggtgga  ttgtgtccc  taaggggta  4380
aacagccgt  taccgcaga  cctctcata  acccttcta  gggaggcgg  tgggggagg  4440
agggatcat  accccttct  tgccttggg  tgccggagc  gggggacct  gaggcccat  4500
agccggagc  acgtgaaag  tactgaaga  agctgagac  cggctgtga  gagcgcctc  4560
gcggtgagg  ggtttaggg  taaatgttt  tggaaccct  tggtccccc  taatgttga  4620
agatatcat  tgcactggg  gttaaatat  tttaattta  tgatcatta  atatgtggg  4680
gttaatatg  tgtttttct  tccctttaa  gtctttaca  gtaattgta  ctgtataat  4740
gttattttt  ttttgcatc  taagtctta  aaattaaga  attccatcg  gaggatgag  4800
gaggtcctc  gtgtgtttt  ggtctggtt  tagggaagg  ctcaagtcc  ggaatgtcc  4860
ccactggtc  actgagttg  agtcacact  ttccaatgg  ttatttgct  tcggttgta  4920
atttaattg  acatatggt  gatttatta  ttttaaaaa  acagactaa  tgatgtaat  4980
tttatgtat  agttgcacc  aaaatcaag  acaaaaata  gtgtgtttg  ttttacagg  5040
gtgaaagtc  cagcttgta  ataagtgtt  tatgtatta  accttttcc  gttctccaa  5100
gcgatgt  5107



<210> 5495
<211> 1259
<212> PRT
<213> Homo sapiens
<308> P48553
<400> 5495

Met Asp Ala Ser Glu Glu Pro Leu Pro Pro Val Ile Tyr Thr Met Glu 
  1               5                  10                  15
Asn Lys Pro Ile Val Thr Cys Ala Gly Asp Gln Asn Leu Phe Thr Ser 
             20                  25                  30
Val Tyr Pro Thr Leu Ser Gln Gln Leu Pro Arg Glu Pro Met Glu Trp 
         35                  40                  45
Arg Arg Ser Tyr Gly Arg Ala Pro Lys Met Ile His Leu Glu Ser Asn 
     50                  55                  60
Phe Val Gln Phe Lys Glu Glu Leu Leu Pro Lys Glu Gly Asn Lys Ala 
 65                  70                  75                  80
Leu Leu Thr Phe Pro Phe Leu His Ile Tyr Trp Thr Glu Cys Cys Asp 
                 85                  90                  95
Thr Glu Val Tyr Lys Ala Thr Val Lys Asp Asp Leu Thr Lys Trp Gln 
             100                105                110
Asn Val Leu Lys Ala His Ser Ser Val Asp Trp Leu Ile Val Ile Val 
         115                120                125
Glu Asn Asp Ala Lys Lys Lys Asn Lys Thr Asn Ile Leu Pro Arg Thr 
     130                135                140
Ser Ile Val Asp Lys Ile Arg Asn Asp Phe Cys Asn Lys Gln Ser Asp 
 145                150                155                160
Arg Cys Val Val Leu Ser Asp Pro Leu Lys Asp Ser Ser Arg Thr Gln 
                 165                170                175
Glu Ser Trp Asn Ala Phe Leu Thr Lys Leu Arg Thr Leu Leu Leu Met 
             180                185                190
Ser Phe Thr Lys Asn Leu Gly Lys Phe Glu Asp Asp Met Arg Thr Leu 
         195                200                205
Arg Glu Lys Arg Thr Glu Pro Gly Trp Ser Phe Cys Glu Tyr Phe Met 
     210                215                220
Val Gln Glu Glu Leu Ala Phe Val Phe Glu Met Leu Gln Gln Phe Glu 
 225                230                235                240
Asp Ala Leu Val Gln Tyr Asp Glu Leu Asp Ala Leu Phe Ser Gln Tyr 
                 245                250                255
Val Val Asn Phe Gly Ala Gly Asp Gly Ala Asn Trp Leu Thr Phe Phe 
             260                265                270
Cys Gln Pro Val Lys Ser Trp Asn Gly Leu Ile Leu Arg Lys Pro Ile 
         275                280                285
Asp Met Glu Lys Arg Glu Ser Ile Gln Arg Arg Glu Ala Thr Leu Leu 
     290                295                300
Asp Leu Arg Ser Tyr Leu Phe Ser Arg Gln Cys Thr Leu Leu Leu Phe 
 305                310                315                320
Leu Gln Arg Pro Trp Glu Val Ala Gln Arg Ala Leu Glu Leu Leu His 
                 325                330                335
Asn Cys Val Gln Glu Leu Lys Leu Leu Glu Val Ser Val Pro Pro Gly 
             340                345                350
Ala Leu Asp Cys Trp Val Phe Leu Ser Cys Leu Glu Val Leu Gln Arg 
         355                360                365
Ile Glu Gly Cys Cys Asp Arg Ala Gln Ile Asp Ser Asn Ile Ala His 
     370                375                380
Thr Val Gly Leu Trp Ser Tyr Ala Thr Glu Lys Leu Lys Ser Leu Gly 
 385                390                395                400
Tyr Leu Cys Gly Leu Val Ser Glu Lys Gly Pro Asn Ser Glu Asp Leu 
                 405                410                415
Asn Arg Thr Val Asp Leu Leu Ala Gly Leu Gly Ala Glu Arg Pro Glu 
             420                425                430
Thr Ala Asn Thr Ala Gln Ser Pro Tyr Lys Lys Leu Lys Glu Ala Leu 
         435                440                445
Ser Ser Val Glu Ala Phe Glu Lys His Tyr Leu Asp Leu Ser His Ala 
     450                455                460
Thr Ile Glu Met Tyr Thr Ser Ile Gly Arg Ile Arg Ser Ala Lys Phe 
 465                470                475                480
Val Gly Lys Asp Leu Ala Glu Phe Tyr Met Arg Lys Lys Ala Pro Gln 
                 485                490                495
Lys Ala Glu Ile Tyr Leu Gln Gly Ala Leu Lys Asn Tyr Leu Ala Glu 
             500                505                510
Gly Trp Ala Leu Pro Ile Thr His Thr Arg Lys Gln Leu Ala Glu Cys 
         515                520                525
Gln Lys His Leu Gly Gln Ile Glu Asn Tyr Leu Gln Thr Ser Ser Leu 
     530                535                540
Leu Ala Ser Asp His His Leu Thr Glu Glu Glu Arg Lys His Phe Cys 
 545                550                555                560
Gln Glu Ile Leu Asp Phe Ala Ser Gln Pro Ser Asp Ser Pro Gly His 
                 565                570                575
Lys Ile Val Leu Pro Met His Ser Phe Ala Gln Leu Arg Asp Leu His 
             580                585                590
Phe Asp Pro Ser Asn Ala Val Val His Val Gly Gly Val Leu Cys Val 
         595                600                605
Glu Ile Thr Met Tyr Ser Gln Met Pro Val Pro Val His Val Glu Gln 
     610                615                620
Ile Val Val Asn Val His Phe Ser Ile Glu Lys Asn Ser Tyr Arg Lys 
 625                630                635                640
Thr Ala Glu Trp Leu Thr Lys His Lys Thr Ser Asn Gly Ile Ile Asn 
                 645                650                655
Phe Pro Pro Glu Thr Ala Pro Phe Pro Val Ser Gln Asn Ser Leu Pro 
             660                665                670
Ala Leu Glu Leu Tyr Glu Met Phe Glu Arg Ser Pro Ser Asp Asn Ser 
         675                680                685
Leu Asn Thr Thr Gly Ile Ile Cys Arg Asn Val His Met Leu Leu Arg 
     690                695                700
Arg Gln Glu Ser Ser Ser Ser Leu Glu Met Pro Ser Gly Val Ala Leu 
 705                710                715                720
Glu Glu Gly Ala His Val Leu Arg Cys Ser His Val Thr Leu Glu Pro 
                 725                730                735
Gly Ala Asn Gln Ile Thr Phe Arg Thr Gln Ala Lys Glu Pro Gly Thr 
             740                745                750
Tyr Thr Leu Arg Gln Leu Cys Ala Ser Val Gly Ser Val Trp Phe Val 
         755                760                765
Leu Pro His Ile Tyr Pro Ile Val Gln Tyr Asp Val Tyr Ser Gln Glu 
     770                775                780
Pro Gln Leu His Val Glu Pro Leu Ala Asp Ser Leu Leu Ala Gly Ile 
 785                790                795                800
Pro Gln Arg Val Lys Phe Thr Val Thr Thr Gly His Tyr Thr Ile Lys 
                 805                810                815
Asn Gly Asp Ser Leu Gln Leu Ser Asn Ala Glu Ala Met Leu Ile Leu 
             820                825                830
Cys Gln Ala Glu Ser Arg Ala Val Val Tyr Ser Asn Thr Arg Glu Gln 
         835                840                845
Ser Ser Glu Ala Ala Leu Arg Ile Gln Ser Ser Asp Lys Val Thr Ser 
     850                855                860
Ile Ser Leu Pro Val Ala Pro Ala Tyr His Val Ile Glu Phe Glu Leu 
 865                870                875                880
Glu Val Leu Ser Leu Pro Ser Ala Pro Ala Leu Gly Gly Glu Ser Asp 
                 885                890                895
Met Leu Gly Met Ala Glu Pro His Arg Lys His Lys Asp Lys Gln Arg 
             900                905                910
Thr Gly Arg Cys Met Val Thr Thr Asp His Lys Val Ser Ile Asp Cys 
         915                920                925
Pro Trp Ser Ile Tyr Ser Thr Val Ile Ala Leu Thr Phe Ser Val Pro 
     930                935                940
Phe Arg Thr Thr His Ser Leu Leu Ser Ser Gly Thr Arg Lys Tyr Val 
 945                950                955                960
Gln Val Cys Val Gln Asn Leu Ser Glu Leu Asp Phe Gln Leu Ser Asp 
                 965                970                975
Ser Tyr Leu Val Asp Thr Gly Asp Ser Thr Asp Leu Gln Leu Val Pro 
             980                985                990
Leu Asn Thr Gln Ser Gln Gln Pro Ile Tyr Ser Lys Gln Ser Val Phe 
         995                1000                1005
Phe Val Trp Glu Leu Lys Trp Thr Glu Glu Pro Pro Pro Ser Leu His 
     1010                1015                1020
Cys Arg Phe Ser Val Gly Phe Ser Pro Ala Ser Glu Glu Gln Leu Ser 
 1025                1030                1035                1040
Ile Ser Leu Lys Pro Tyr Thr Tyr Glu Phe Lys Val Glu Asn Phe Phe 
                 1045                1050                1055
Thr Leu Tyr Asn Val Lys Ala Glu Ile Phe Pro Pro Ser Gly Met Glu 
             1060                1065                1070
Tyr Cys Arg Thr Gly Ser Leu Cys Ser Leu Glu Val Leu Ile Thr Arg 
         1075                1080                1085
Leu Ser Asp Leu Leu Glu Val Asp Lys Asp Glu Ala Leu Thr Glu Ser 
     1090                1095                1100
Asp Glu His Phe Ser Thr Lys Leu Met Tyr Glu Val Val Asp Asn Ser 
 1105                1110                1115                1120
Ser Asn Trp Ala Val Cys Gly Lys Ser Cys Gly Val Ile Ser Met Pro 
                 1125                1130                1135
Val Ala Ala Arg Ala Thr His Arg Val His Met Glu Val Met Pro Leu 
             1140                1145                1150
Phe Ala Gly Tyr Leu Pro Leu Pro Asp Val Arg Leu Phe Lys Tyr Leu 
         1155                1160                1165
Pro His His Ser Ala His Ser Ser Gln Leu Asp Ala Asp Ser Trp Ile 
     1170                1175                1180
Glu Asn Asp Ser Leu Ser Val Asp Lys His Gly Asp Asp Gln Pro Asp 
 1185                1190                1195                1200
Ser Ser Ser Leu Lys Ser Arg Gly Ser Val His Ser Ala Cys Ser Ser 
                 1205                1210                1215
Glu His Lys Gly Leu Pro Met Pro Arg Leu Gln Ala Leu Pro Ala Gly 
             1220                1225                1230
Gln Val Phe Asn Ser Ser Ser Gly Thr Gln Val Leu Val Ile Pro Ser 
         1235                1240                1245
Gln Asp Asp His Val Leu Glu Val Ser Val Thr 
     1250                1255



<210> 5496
<211> 523
<212> DNA
<213> Rattus norvegicus
<308> AA891724
<400> 5496

ggtcctacc  atgtgactc  ttacccagg  ccacttttc  tatgtgtgc  ggctgtgga  60
acggtccgc  atcaaccgc  acctaagtc  cggttagtc  caccttcct  tgccttctc  120
tcacttggc  tcattgtct  agaaaccga  ggcatctgt  cgttactgt  tcgggtctg  180
gtaaaggta  cttggcagg  gaacatgca  atgactttt  aaataaaga  caacattct  240
acactaagg  aacacacag  aaaaataca  tacttagac  tcgttgcaa  taaataccc  300
gtacagatg  tgttatctt  aatgtaaca  tgttttatg  gaatcaaca  tgtaacaga  360
ggcaaagag  cccaacaag  aggaataag  aatgctcat  ccaggaaac  gaattcttc  420
atttctaac  atttatatt  ttgtaattt  tcccttttt  ggccggagg  caacttctt  480
tcctccact  gtaccaatt  gaccacacc  tggaactca  tta  523



<210> 5497
<211> 6408
<212> DNA
<213> Homo sapiens
<308> XM_046863
<400> 5497

tgaggaggg  ccggcctgc  agagcctca  tgggagccg  ctcagccct  ggccaccat  60
tcggcgccg  cggaggagg  ggagtacgc  cggctggtg  tggaggcgc  gccggagtg  120
ctgcgcgcc  aggtgaagc  gctgtccca  gagctggcc  agaccacgc  tgagaagat  180
caggcggcc  agtacgggc  ggcggtgct  gaggagaag  accagctca  gctgcagtt  240
gaggagctc  aggtggact  tgaggctat  cgcagcgag  tggagcagc  caaggaggc  300
tttggacaa  cacacacaa  ccacaagaa  gtggctgct  acggagaga  ccgggagga  360
agcctgatc  aggagtcgg  ctccaagga  cagtactac  tgcggaagg  gctagagct  420
cagacggag  tgaagcagt  gcgcaatgt  ctcaccaac  cgcagtcgg  gaatgagcg  480
ctggcctct  tggcccagg  gctgaagga  atcaaccag  atgtggaga  ccagcgtgg  540
cgcctgcgg  atgacatca  ggagtacaa  ttccgggaa  ctcgtctgc  gcaggacta  600
tcggaactg  aggaggaga  catcagcct  cagaagcaa  tgtctgtgc  cagacagaa  660
caggtggag  ttgagggcc  caagcatga  atcaagcgt  tggaggagg  gaccgagta  720
ctcaacagc  agctggagg  tgccatccg  ctcaaggag  tctcagagc  gcagctgga  780
gaggcgctg  agaccctga  gacggagcg  gaacagaag  acagcctgc  caaggagct  840
tcacactac  tgagcatca  tgactcctt  tacaccagc  acctgcatg  ctcgctgga  900
ggcctcaag  tcagtgacg  tgctgccga  cccaacaac  atgccgagg  cctggtcaa  960
ggctttgag  acggcggcc  ggccaagct  ccactggac  acaagacct  cacgcccaa  1020
aaggagggc  tcgcaccgc  ctcccccag  ctcgtctcc  acctactca  tgagctcaa  1080
atctctgag  tccagaagc  gaagcagca  ctgatgcag  tggagcggg  aaaggcggg  1140
ctgctggca  cgctgcagg  cacacagaa  cagctggag  acacgcggg  ctccctgtc  1200
gaacagcag  agaaggtga  ccgcctcac  gagaatctg  gtgccctgc  gcgcctgca  1260
gccagcaag  agcggcaga  agccctgga  aacgagaag  accgtgaca  ccatgagga  1320
ggggactac  acgaggtgg  catcaacgg  cctgagatc  tggcctgca  gtaccatgt  1380
gctgtggct  aggctggcg  gctccgcga  cagctcaag  cactgcgca  cacgcacga  1440
gctcgtgag  cccagcacg  cgaggagaa  ggccgctat  aggctgagg  ccaggcact  1500
acggagaag  tctccctgc  agagaaggc  agccgccag  accgcgagc  gctggcccg  1560
ctggagaag  agctaaaga  ggtgagcga  gtcgccggc  agacacagg  cagcctgag  1620
gtggcccag  atgagctgg  gaccttcag  gaggagctg  ccaatctct  ccaccacgt  1680
tgcatgtgc  acaatgaga  acccaaccg  gtcatgctg  actactacc  cgagggcca  1740
ggcggggcc  gccgcacca  tcccggggg  cgcaccagc  ccgaggcgc  tggccggcg  1800
tcacccatc  tcctaccca  ggggctgct  gctcctgag  cgggccgag  agatggtgg  1860
acgggggac  gcagcccct  gcctggctc  tcactgcca  cacccctga  tgacccacg  1920
cgggagccc  tgaacatct  caacctgat  gctatcatc  gtgaccaga  caagcacct  1980
caggcagcc  tggaccgca  cacggagct  tcacgccag  gcattgcct  tcaggagct  2040
ggccccgcc  tggacaagg  caaggaagc  cttatggag  agatcctca  gctgaagtc  2100
ctgctcagc  ccaagcggg  gcagatcac  acgctgcgc  ctgtgctca  ggccaacaa  2160
cagacggcc  aggtggccc  tgccaacct  aagagcaag  atgagaatg  gaaggccat  2220
gttaccgag  ccatgatga  gctgcgcaa  gagctcaag  ccctcaagg  ggacgcagc  2280
accttctcc  cgctgcgtg  tatgtttgc  accaggtgt  acgagtaca  tacacagct  2340
gatgagatg  agcggcagc  ggcggctgc  gaggacgag  agaagacgc  gaactcgct  2400
ctgcgcatg  ccatccagc  gaagctggc  ctgacccag  ggctggagc  gctcgagct  2460
gaccatgag  agacccggc  tggccgtgc  aaagccgcc  cgaagacca  gccagccac  2520
ccgagcgta  gtcacacct  tgcctgtgc  agcgacagg  ccgagggca  cgggctggc  2580
aaccaggtg  tctgcagcg  gaagcacag  atttactgt  attaggggc  gtggggcgc  2640
gcacgctgc  gctaacatc  gcttcacct  aactaaccc  gcagcagcg  gacggcggt  2700
ctaggtcaa  cttaacgtg  ctaatgcac  gagggtagg  gtctagccg  ggcgccatg  2760
ggcgttgca  cagcaggac  cttgtgaga  ctttgtgtc  cttctcact  ctcaaagcc  2820
cctcaggag  acccagtcc  cagctgctc  cttaggtgg  ggtcagagg  ggggataga  2880
ctgcacatt  ttgcagcag  tgtgtgatg  aagcatctt  taagccctg  gcacccgtg  2940
ggaaaccca  gggaggagt  ctggtcctg  tccctcagc  cccaaaagg  gcagaacct  3000
agttgagac  tgcatgttc  tcgcatgtg  ctaatgtca  cactagaaa  cagttttag  3060
aggttccag  ctgcagcat  ggtacgacc  cagaggatg  ctttgcact  ggcatagtt  3120
catggaaag  agtacgttg  agtttatgc  gtatctgac  gcaaatcat  ttcaggaaa  3180
aagtgcaga  tttcttccc  aagcccaga  aagagcagc  ctgagcccc  gtattctgc  3240
ggccagaca  acatggcac  gacacagct  accataacc  aggaatcca  agctcggtt  3300
ctcatttct  agatcagga  gcttgtata  tggcctgtg  ggtgacaga  tggcagggc  3360
caaggcccc  ggttttcat  tttcatgag  aaagctttc  aagtgcctg  ccagacctt  3420
gtccttagt  cagagcccg  ccttttgta  ttggggtga  cccagcagc  aattatccg  3480
ccttccata  ggggttcag  cccaaagac  tggggcttt  aaaacccta  cctgaagtc  3540
gagccacca  gggcttggc  gggttggac  cccacaggt  tatccagag  ccagcccgg  3600
gctgggaaa  ctttgcata  ggccagggc  acttgtcag  attcacagg  aggagatgt  3660
taggtctct  tatttagtg  aatctgggg  atggcaaca  agaaagagg  aaggtagct  3720
tagggttct  ccatttcca  aggctccat  cacacctgc  ttcccacat  ctgagcaga  3780
cttttctca  tactttttt  ccgatcacc  tgtgggacc  gctggacct  aggctgcag  3840
cttctctcc  gcaggctgc  tgccttgtc  ctcatgcgg  agaggcatt  gagttacct  3900
gtgagagac  gtgttgccc  ctcccacag  tctctgccc  gcgcgttct  ccctttggt  3960
ccgagtatg  ttcggtccc  tccagactc  aggacacgc  catgtatgt  ccctgcgtg  4020
tcatcctgg  cccagatcc  cctgcccca  caagactcg  agtgggatg  ctgctggca  4080
gcccaccct  catgcgctt  gccctctcc  tgcaagcct  gcacatagc  tctctccat  4140
ctcctaagg  actttgcag  cacccaagc  actgggacc  ctgctaaca  atgcaggtc  4200
tctcttctg  caactaacg  gctcgcgcc  tcccagcac  tggagagct  caattgtca  4260
ataaacagg  agcgacaga  gaccgcttt  taacgctct  ttttctccc  ttttcagct  4320
tagagtagc  gccaggagg  cttggccac  cggccctgt  acactgcag  cccttcccc  4380
tccctctcg  ggcccacaa  gaggaagga  gggcaacct  aaagcccac  tagaaactt  4440
ttggatatg  cactgcaat  cttttcaaa  tagcattcc  caggttttt  atgggagga  4500
aaaaagctt  aatgttgag  atgctgcga  ctgctgcgt  gaaaggcct  tgtatgggc  4560
gaagaccct  cttccctgg  tgccaggct  gccaggagc  cactggaaa  gcccaccac  4620
ggggctcct  gttacacat  ttctttttt  atccgatca  cctgtgcac  tttgatatt  4680
tgatattat  tttgcttcc  taattcctc  cgtagagac  gtctcaggt  ccgtggtct  4740
tgctcgtgg  cctgtagct  tccgcctca  ctcccaccg  gtttgtctg  tgtcagcac  4800
aggcagagc  gtgtgctcc  tagcgtgta  ctttagact  ggagatgag  gctttgacc  4860
agcgaggag  tcagctaag  gtatccacg  tgtggttca  cagccttta  atcatacgg  4920
attgtggtt  atgtttgaa  ttacagatt  taaatgcca  gttcattaa  aaatccagg  4980
tattcagat  ctggggttt  tcatattgt  ttattatta  tcttaggaa  agttcaatg  5040
aacaagaag  aaacttgac  tttgctctg  ttaaaacag  aataggcac  tgaaaaaaa  5100
agataaatt  ttgaatgag  agtattacc  acaaattcc  gaattttct  ggttttagg  5160
cgttgtgaa  catgactga  taacagaat  ttatacaac  gtaccaata  aattccaaa  5220
tggaattgt  ttgttactc  ggttgttgt  ccaaattgt  gtacactta  aaaattcta  5280
agtcgtcga  ttttagggt  ttctctttc  acacctttt  gttagtaat  attgccagt  5340
gtgccttca  cagttaagg  aggtgtccc  gcacagatc  ttctcaaaa  cgagcaggg  5400
agagctagt  ggcatgctg  aggccagcg  ggacagcag  tgaggcagg  gctcctcac  5460
cccagacct  ggcatcttc  ttgagggaa  gaaaacagt  attgtgcaa  attctgtta  5520
tcagtgatt  tttacttgc  aattcaggg  cttagaaaa  gaaagcaaa  acaaaacct  5580
gagtgtgct  tgggaacca  atggacctt  tgggacaag  tgagcaagc  gtatgaacg  5640
cacgtttgt  aagagctga  ggtatcagg  gggccgacg  tgtgttggc  tgcgcagta  5700
gggatgagg  ttagccata  tattctttg  aaatgtgaa  gcgagacat  atatcttct  5760
ttgcttggt  taactaatc  ctgttaatt  caggaaaca  aactcatta  aactcctta  5820
caaaccagg  ctacatcct  ttttgtttg  tgagtgagg  tagtgggag  ggtcaaatt  5880
gtactcttg  aggaagaaa  actgtcctt  cttctccaa  aaaggaaaa  ttataataa  5940
ataaatgac  aaaataaaa  aattctgtt  cctggaata  gcatttctt  ttcctagtt  6000
tagggactc  tatttttac  ttccgttac  gtgttgatt  ataagaaat  ttgttacat  6060
tgagataac  tcatctgta  ggggtattt  tttgcaatg  tgtctgagt  ctgtatttt  6120
tctgtgcat  accttagtg  cagaatgtt  gtctttatt  taaagtcat  tgcatgttc  6180
cctgccaag  aacctttac  cagacccaa  caaaaaaat  ataatcaaa  gccttcaat  6240
tctgagaaa  tgaggcaga  catggaaaa  gaataggaa  gagaaatta  ttgagattt  6300
caggacaca  acatatgat  tgaatgcct  caaagccag  gcgcatagg  acagtgggc  6360
tgggtaaag  gtcacattg  taggaccaa  aaagaataa  aaaaagac  6408



<210> 5498
<211> 855
<212> PRT
<213> Homo sapiens
<308> XP_046863
<400> 5498

Met Ser Ala Pro Ser Glu Glu Glu Glu Tyr Ala Arg Leu Val Met Glu 
  1               5                  10                  15
Ala Gln Pro Glu Trp Leu Arg Ala Glu Val Lys Arg Leu Ser His Glu 
             20                  25                  30
Leu Ala Glu Thr Thr Arg Glu Lys Ile Gln Ala Ala Glu Tyr Gly Leu 
         35                  40                  45
Ala Val Leu Glu Glu Lys His Gln Leu Lys Leu Gln Phe Glu Glu Leu 
     50                  55                  60
Glu Val Asp Tyr Glu Ala Ile Arg Ser Glu Met Glu Gln Leu Lys Glu 
 65                  70                  75                  80
Ala Phe Gly Gln Ala His Thr Asn His Lys Lys Val Ala Ala Asp Gly 
                 85                  90                  95
Glu Ser Arg Glu Glu Ser Leu Ile Gln Glu Ser Ala Ser Lys Glu Gln 
             100                105                110
Tyr Tyr Val Arg Lys Val Leu Glu Leu Gln Thr Glu Leu Lys Gln Leu 
         115                120                125
Arg Asn Val Leu Thr Asn Thr Gln Ser Glu Asn Glu Arg Leu Ala Ser 
     130                135                140
Val Ala Gln Glu Leu Lys Glu Ile Asn Gln Asn Val Glu Ile Gln Arg 
 145                150                155                160
Gly Arg Leu Arg Asp Asp Ile Lys Glu Tyr Lys Phe Arg Glu Ala Arg 
                 165                170                175
Leu Leu Gln Asp Tyr Ser Glu Leu Glu Glu Glu Asn Ile Ser Leu Gln 
             180                185                190
Lys Gln Val Ser Val Leu Arg Gln Asn Gln Val Glu Phe Glu Gly Leu 
         195                200                205
Lys His Glu Ile Lys Arg Leu Glu Glu Glu Thr Glu Tyr Leu Asn Ser 
     210                215                220
Gln Leu Glu Asp Ala Ile Arg Leu Lys Glu Ile Ser Glu Arg Gln Leu 
 225                230                235                240
Glu Glu Ala Leu Glu Thr Leu Lys Thr Glu Arg Glu Gln Lys Asn Ser 
                 245                250                255
Leu Arg Lys Glu Leu Ser His Tyr Met Ser Ile Asn Asp Ser Phe Tyr 
             260                265                270
Thr Ser His Leu His Val Ser Leu Asp Gly Leu Lys Phe Ser Asp Asp 
         275                280                285
Ala Ala Glu Pro Asn Asn Asp Ala Glu Ala Leu Val Asn Gly Phe Glu 
     290                295                300
His Gly Gly Leu Ala Lys Leu Pro Leu Asp Asn Lys Thr Ser Thr Pro 
 305                310                315                320
Lys Lys Glu Gly Leu Ala Pro Pro Ser Pro Ser Leu Val Ser Asp Leu 
                 325                330                335
Leu Ser Glu Leu Asn Ile Ser Glu Ile Gln Lys Leu Lys Gln Gln Leu 
             340                345                350
Met Gln Met Glu Arg Glu Lys Ala Gly Leu Leu Ala Thr Leu Gln Asp 
         355                360                365
Thr Gln Lys Gln Leu Glu His Thr Arg Gly Ser Leu Ser Glu Gln Gln 
     370                375                380
Glu Lys Val Thr Arg Leu Thr Glu Asn Leu Ser Ala Leu Arg Arg Leu 
 385                390                395                400
Gln Ala Ser Lys Glu Arg Gln Thr Ala Leu Asp Asn Glu Lys Asp Arg 
                 405                410                415
Asp Ser His Glu Asp Gly Asp Tyr Tyr Glu Val Asp Ile Asn Gly Pro 
             420                425                430
Glu Ile Leu Ala Cys Lys Tyr His Val Ala Val Ala Glu Ala Gly Glu 
         435                440                445
Leu Arg Glu Gln Leu Lys Ala Leu Arg Ser Thr His Glu Ala Arg Glu 
     450                455                460
Ala Gln His Ala Glu Glu Lys Gly Arg Tyr Glu Ala Glu Gly Gln Ala 
 465                470                475                480
Leu Thr Glu Lys Val Ser Leu Leu Glu Lys Ala Ser Arg Gln Asp Arg 
                 485                490                495
Glu Leu Leu Ala Arg Leu Glu Lys Glu Leu Lys Lys Val Ser Asp Val 
             500                505                510
Ala Gly Glu Thr Gln Gly Ser Leu Ser Val Ala Gln Asp Glu Leu Val 
         515                520                525
Thr Phe Ser Glu Glu Leu Ala Asn Leu Tyr His His Val Cys Met Cys 
     530                535                540
Asn Asn Glu Thr Pro Asn Arg Val Met Leu Asp Tyr Tyr Arg Glu Gly 
 545                550                555                560
Gln Gly Gly Ala Gly Arg Thr Ser Pro Gly Gly Arg Thr Ser Pro Glu 
                 565                570                575
Ala Arg Gly Arg Arg Ser Pro Ile Leu Leu Pro Lys Gly Leu Leu Ala 
             580                585                590
Pro Glu Ala Gly Arg Ala Asp Gly Gly Thr Gly Asp Ser Ser Pro Ser 
         595                600                605
Pro Gly Ser Ser Leu Pro Ser Pro Leu Ser Asp Pro Arg Arg Glu Pro 
     610                615                620
Met Asn Ile Tyr Asn Leu Ile Ala Ile Ile Arg Asp Gln Ile Lys His 
 625                630                635                640
Leu Gln Ala Ala Val Asp Arg Thr Thr Glu Leu Ser Arg Gln Arg Ile 
                 645                650                655
Ala Ser Gln Glu Leu Gly Pro Ala Val Asp Lys Asp Lys Glu Ala Leu 
             660                665                670
Met Glu Glu Ile Leu Lys Leu Lys Ser Leu Leu Ser Thr Lys Arg Glu 
         675                680                685
Gln Ile Thr Thr Leu Arg Thr Val Leu Lys Ala Asn Lys Gln Thr Ala 
     690                695                700
Glu Val Ala Leu Ala Asn Leu Lys Ser Lys Tyr Glu Asn Glu Lys Ala 
 705                710                715                720
Met Val Thr Glu Thr Met Met Lys Leu Arg Asn Glu Leu Lys Ala Leu 
                 725                730                735
Lys Glu Asp Ala Ala Thr Phe Ser Ser Leu Arg Ala Met Phe Ala Thr 
             740                745                750
Arg Cys Asp Glu Tyr Ile Thr Gln Leu Asp Glu Met Gln Arg Gln Leu 
         755                760                765
Ala Ala Ala Glu Asp Glu Lys Lys Thr Leu Asn Ser Leu Leu Arg Met 
     770                775                780
Ala Ile Gln Gln Lys Leu Ala Leu Thr Gln Arg Leu Glu Leu Leu Glu 
 785                790                795                800
Leu Asp His Glu Gln Thr Arg Arg Gly Arg Ala Lys Ala Ala Pro Lys 
                 805                810                815
Thr Lys Pro Ala Thr Pro Ser Val Ser His Thr Cys Ala Cys Ala Ser 
             820                825                830
Asp Arg Ala Glu Gly Thr Gly Leu Ala Asn Gln Val Phe Cys Ser Glu 
         835                840                845
Lys His Ser Ile Tyr Cys Asp 
     850                855



<210> 5499
<211> 642
<212> DNA
<213> Rattus norvegicus
<308> AA891725
<400> 5499

gcagttaca  gattttttt  tattacata  acataatat  ttccaccgc  gttggtctt  60
agttcgctt  tcactttga  ggagtgtca  gtgtggcag  gactaagaa  ggtttaaga  120
aacaaaagc  ttttcgcac  tctgaaaac  ttttattgc  tacgtctcc  gattacctt  180
ttaagaaaa  aaaaataac  ggttttgtt  atttttaca  tgtaatgtt  tgctccaag  240
tataaaaac  ggacttctc  acaagtccc  ttttgttta  aaaggtcta  aaaaataca  300
aaggaactt  atgtttgtc  tttaactta  ttattccag  ttaccagat  cccccagat  360
tgcaaacca  attaatctt  cagcaatac  atgtcaaca  catcatgaa  accttgcaa  420
agcagctct  ctgcgtacg  aacaatctt  cttcgtttt  cggctttca  agttcccac  480
aacgcttca  agagattgg  acatctgtc  tcttggaag  ggaccccaa  cttcacact  540
agtttccca  cggcatttt  ggaacccag  cgatgaatt  cctccacca  gaggttaac  600
tcatgctcc  cgttcattg  tgaccctcc  attgcttcc  tc  642



<210> 5500
<211> 743
<212> DNA
<213> Homo sapiens
<308> BC014953
<400> 5500

ctgaagaag  taaccgggt  cagacccac  cggcgccag  tctccggcg  gaaggaaaa  60
cgcgcagag  gcaatgaat  tggatcacg  ggttaacct  ttagtggag  aaattcatc  120
tttgggttc  aaaaatgct  atggaaagt  aagcgtgaa  tttggggtc  tcttccgtg  180
tgataaatg  gccaacctc  ttgaagcat  ggtaggaac  cttaaagct  caaaacgaa  240
gaagattgt  acatatcca  gagagctgc  tctgcaagg  gttcatgat  atgttgaca  300
tatattact  caagattaa  gtggtttac  tatctttat  tactgccat  ttttgtttc  360
ggtaaactg  aatataaag  gaaagaaca  acatttgaa  atacttaat  tatttttat  420
gaactttgt  aacgaaagg  gattcatgt  ttagaagtc  gtccttttt  atatcttga  480
agaaaatct  tgtatgatg  tataaaata  atcctatta  ttttctcag  aatctggtt  540
ggaattgca  gcaatgaga  tttttgcgg  gcagggatg  gaatgtttg  tcataaata  600
ttagacatt  tctatagat  tttgacatt  tgcgaaagc  acaagcaaa  tgaagacca  660
ctcctatga  aaatattat  atgtttatg  aataaagac  tgtaactgt  ttaaaaaaa  720
aaaaaaaaa  aaaaaaaaa  aaa  743



<210> 5501
<211> 82
<212> PRT
<213> Homo sapiens
<308> BC014953
<400> 5501

Met Asn Val Asp His Glu Val Asn Leu Leu Val Glu Glu Ile His Arg 
  1               5                  10                  15
Leu Gly Ser Lys Asn Ala Asp Gly Lys Leu Ser Val Lys Phe Gly Val 
             20                  25                  30
Leu Phe Arg Asp Asp Lys Cys Ala Asn Leu Phe Glu Ala Leu Val Gly 
         35                  40                  45
Thr Leu Lys Ala Ala Lys Arg Arg Lys Ile Val Thr Tyr Pro Gly Glu 
     50                  55                  60
Leu Leu Leu Gln Gly Val His Asp Asp Val Asp Ile Ile Leu Leu Gln 
 65                  70                  75                  80
Asp Ter 
                 85



<210> 5502
<211> 418
<212> DNA
<213> Rattus norvegicus
<308> AA891727
<400> 5502

ggggaaact  ggcagttta  tgacaggca  caggagact  cgcagtcag  tccgtgggc  60
ggacagcac  cgagtccag  ctctgtgct  ctcctcggg  cttgtgggc  caaacttct  120
ctgcagttt  ctccacaca  tcttattca  ctcttgaaa  tcctccaaa  tgtctgtgg  180
caggatcag  ttgtactct  ccacggaca  gccactgaa  ctggtgtct  tggggcagg  240
tacttgtgc  tgtagtagt  tgaatgcag  cgtgctaag  tctcgtaca  ctgatcaca  300
gcctcgggt  ctgcaacct  ggtgttctc  ccctcccga  aggcctgtg  tacccgctg  360
cgcaggtaa  cgcccaagt  ccggccccg  ttggtctcg  ccactggcc  ctcgtgcc  418



<210> 5503
<211> 536
<212> DNA
<213> Homo sapiens
<308> BC006007
<400> 5503

gccgactcc  cccgctaag  cgggaacac  cggggccca  gatggcggc  agccggtac  60
ggcgttttc  taagctctg  gaggaatgg  cagtggacg  gaccaaacg  ggccgggac  120
tgggcgctt  cctgcgaca  cgggtagca  aggcctttc  ggagggaga  aatacccag  180
ttgcagagc  tgaggcctg  gatcagatg  acgagagct  agcgcgact  cattcaaac  240
actacaaac  caagtaccc  cgccccaga  acaccagct  cagtggcct  tcgttggaa  300
agtacaagc  gatcctgtc  acagacacc  tggaagagc  taaggaaat  gataaaggc  360
tgtggaaga  actgcagga  aagtttgcc  ccaagggtc  tgaggagga  cataaggcc  420
gagctcagg  cttacctcg  gcacatacc  aggtgtgga  tcttgtaca  tgccatcgt  480
aataaaact  ccccagttt  cccttgcaa  aaaaaaaaa  aaaaaaaaa  aaaaaa  536



<210> 5504
<211> 127
<212> PRT
<213> Homo sapiens
<308> BC006007
<400> 5504

Met Ala Ala Ser Arg Tyr Arg Arg Phe Leu Lys Leu Cys Glu Glu Trp 
  1               5                  10                  15
Pro Val Asp Glu Thr Lys Arg Gly Arg Asp Leu Gly Ala Tyr Leu Arg 
             20                  25                  30
Gln Arg Val Ala Gln Ala Phe Arg Glu Gly Glu Asn Thr Gln Val Ala 
         35                  40                  45
Glu Pro Glu Ala Cys Asp Gln Met Tyr Glu Ser Leu Ala Arg Leu His 
     50                  55                  60
Ser Asn Tyr Tyr Lys His Lys Tyr Pro Arg Pro Arg Asp Thr Ser Phe 
 65                  70                  75                  80
Ser Gly Leu Ser Leu Glu Glu Tyr Lys Leu Ile Leu Ser Thr Asp Thr 
                 85                  90                  95
Leu Glu Glu Leu Lys Glu Ile Asp Lys Gly Met Trp Lys Lys Leu Gln 
             100                105                110
Glu Lys Phe Ala Pro Lys Gly Pro Glu Glu Asp His Lys Ala Ter 
         115                120                125



<210> 5505
<211> 664
<212> DNA
<213> Rattus norvegicus
<308> AA891733
<400> 5505

aaagcaatc  actaaaaaa  tacaactgt  tttgaacct  ccgatctct  tgagctatg  60
tgatcagaa  tcgggagtc  tttgtgttt  aacaaccac  tgctcactc  ttaacataa  120
tcctgctta  atacgggaa  cgattcaca  ccgccatcc  cctgcacct  ttgcccagg  180
ggcaatgtg  tttagacct  aggtctgta  ttgcaatac  ttttgatgg  agatgttgc  240
caagtgcta  ttgttagct  tgaaatcag  ttttctgct  gttcttaat  ccatggtca  300
atcatagca  aaaatcatt  aaaataatc  gtgataaat  atctgttcc  tggggttgt  360
tgttcactt  tcatagtca  caaatagaa  actgatgta  gtgtatgac  agtcttgga  420
aatacctgt  gtttgtggt  ctggaggga  agctcttgg  tacacacca  cccaaagga  480
actgctgat  cgtccctag  tactgactt  aaaatattt  tcatgtgtc  cagctcatg  540
gtggtgagg  caacctgct  ctgtcatgt  tctctgact  ctacgtgag  tccaagagc  600
ttcttggca  tgaatgcct  tagtccctt  cttactggt  tgtcactga  ttttttaaa  660
aaag  664



<210> 5506
<211> 8494
<212> DNA
<213> Homo sapiens
<308> AF009424
<400> 5506

agcggttca  gctctacgt  cgtgacatc  aacctcctg  tgggccatt  ccgagaact  60
ccatcagtt  ctgtatagt  taaaagttt  agaggcgga  acgagagag  tgcggctgg  120
acaaggagc  cccgcgtgc  ggtgcgacc  tgcaggatg  tggcagcgg  gtggccagg  180
gcgcccgtg  tctgagggc  tgagggcca  cccctccac  cgcgccatg  cctccgcgc  240
ctggctgga  ggctgacgg  agcagggac  gccgccgcc  aggtgccac  cccaggtac  300
gcccgcccg  tgcgagagc  gggcaggtg  gccgcggat  ctcccagag  ccggcccag  360
agagcgatg  acttggaca  gctaagatg  aagtgacct  agcctcgcc  ggcggcttc  420
tcgacggga  agcgcaaga  ttggagcac  ggcttgtcc  gggagcagt  tgccggaag  480
tggttttca  gccacaaat  ctttcacag  gtgcaaatt  acctgcacc  gtggtaaat  540
cttgtatct  ggttcgctg  tctgtaacc  acagaacga  tgtggggac  acagtgacg  600
agagaactg  ctcctggtg  ccgagcacc  gcctccggg  atcttcaac  cggagctgg  660
gttcgccca  atcatcatc  tcgtcgtgg  ggtcacggt  atggtggtg  tcatcgtct  720
cctgctgaa  cactacaaa  tctccacgc  gtccttcat  aaccgcccg  accagagcc  780
gaggcggga  gacgggctg  cgcaggaag  gtgcctgtg  ccttcagac  gcgccgcac  840
gcggctggg  gcctcggag  tcatgcatg  cccgcggtc  agggacagg  tcacagcgc  900
gtccttcat  cagagggat  gcttcagcc  cttccagcc  acctacccc  atgtgcagc  960
cgagattga  cttcctccc  ccatctccc  gtccgacgg  gaagagcca  ctccttacc  1020
ggggccctg  accctgcag  tccgggacc  tgaacagca  atggaactc  accgagagt  1080
cgtgagggc  ccacccaac  gaaccatat  tgacagtga  ttaatagac  ttgctatgt  1140
tagcggggg  ccatgccca  ccagcagca  ctcgggcat  agtgcaagc  cctgcagca  1200
taacgggag  atggagggg  cacccccca  atacagcga  gtgatgggc  accacccag  1260
cgcctcttt  ctccatcac  agcgcagca  cgcacacag  ggcagcaga  tgcagtttc  1320
gcagaacaa  gcagagagc  caatagtac  catcaaagg  aaagatagg  agcctggga  1380
cctggtctg  ttccttcca  cgtgcactt  agctggaga  agaaaccaa  aagggaagc  1440
gccgctggg  ccctcctgc  cacagtgtt  ttcagtttc  catggtaca  ataagtaaa  1500
ccaaatgag  aaacacggt  tttgtttct  attcctttt  ggggaattg  atgcaaact  1560
gactgaaat  atacaaact  ccatctggt  tgaccgcaa  cagtgttta  ttggggaca  1620
gggttggga  gggggtgtg  gcaggggaa  acagagaac  ggatgcttt  aagatacca  1680
gaaataaaa  ccacagagg  atttgatgt  tttaattgt  aaaggagac  ttgcagata  1740
atgaggcca  aatggcatg  tttataatt  actgaataa  gaaggaagc  ttattatat  1800
ttattgtgg  gaagaacca  ccagttcgc  ttttctcct  aggtgtgga  ttttatttt  1860
ttttaaaaa  atgaatcaa  attcctgtg  tgtgtgcca  ggtataaag  ggagaagtt  1920
gatgagtgc  aggagctcc  ttgtgttgt  atgatgtgt  ttaaaagtt  cactatctt  1980
atgttgaaa  tatttacaa  ggaactgtt  tacgtgaag  tctgtatgt  gtcttttca  2040
ctgtggatt  taatcaggc  caaggaata  cctggagtg  tccccagaa  catccaaga  2100
aagatattt  gggacgtag  ctaacattt  accaactta  gtaaatcaa  aaagtcatt  2160
ttgttgcag  agtttgcat  aaatagcag  gcatcgctg  agcttttgg  gacttttgg  2220
tggaagata  gatagggaa  attaagttc  agcatttct  acttgttat  ttgagttac  2280
ctgctactc  taggctgca  agtttatga  aaaatgaac  catgcattt  tggatccag  2340
atcatgcag  gctgccctc  tcctccagc  gtgcaattt  ttcagtaat  tagattttt  2400
tcactatag  atgaaatat  ttcaaatac  taccttatt  tatgcaata  attgtttaa  2460
atgcaaggt  gttattctg  atactgttg  aatatgtga  tcctcagta  attcccatt  2520
cctctcccc  tttcctcga  agcttagtt  agttctgca  ggctgctca  ttcacagga  2580
gctcccagc  gccacccca  atccagcct  cacagaact  tcgtgtggg  gtggtgtgg  2640
tggtggttt  cttatgctt  ggaagcccc  agaaataat  acggaagaa  gccatgttg  2700
tgatcgtgg  aataagcca  tgtgggtta  tgtatgtca  tagtattag  atagcattc  2760
taaaggaat  cagtgttca  aacctaccc  aattccccg  aggatttta  caaaccctt  2820
cccaggcca  ttttgtact  aaggcaaga  ctggacagt  agagaacag  ggagggggc  2880
agtgactga  gagcaccgg  taaaaagca  aacatgcag  taaaatgca  actagaaaa  2940
taattttaa  tattgttag  tttaatatt  cctgatatt  acaaatatt  attcttata  3000
acaatgaaa  aaataactt  cttctgcag  tgtaagcac  ggcttttat  agagcagca  3060
ccaacacgt  tagcagaca  tgcgcgtgg  gaagggctt  tctgcagta  actctgcca  3120
gtggagggt  ggcctctgt  gcctcttca  ataacaaga  gagctggaa  gatgattcc  3180
tgactccca  ctatgcagc  ttaaagcca  atccgcgtg  gtgtgtttg  gtctgtctg  3240
gggtctcga  ggtgatccg  cggtgcggt  gctctgtgc  gtaactgga  agactgttc  3300
aaaccccaa  agttgtctg  tcctagtct  ttcccttct  cttcttacc  ctgtagata  3360
gtcactggt  tttgtttgt  tgttttgag  attggaatt  ccattacat  catcctttg  3420
acacagtaa  atccacaga  ctagtccaa  tcttaaaag  agagaggaa  aacacaggc  3480
ccagttgtc  gctcatgct  acaacctgt  tggaagtat  tacagttga  agtcacagt  3540
gaggttctg  gactggatt  agtcttgtt  cagtgacag  tggaaggcc  ctgctggag  3600
gacaccagc  ctcagggca  agattggct  ggggccaga  ggaccctcc  caaccctgg  3660
gacaccctg  aggttcact  gctctccag  ttagcctct  ttcctctgt  aggcaaaga  3720
gaggagccc  tgttcccat  gggccctgc  ggcagggac  tgcagtgga  tcttggtca  3780
gtgtgccca  agatgcgga  gcgaggtga  tgattccat  atttcagtt  tcacctgca  3840
ttttggtga  gcaggagat  caccccaca  ctctagctc  caaatggct  cacagtcct  3900
acttctcta  ctgcctcaa  aaggggctc  gagcagaga  ttgtgaatt  cttagtaac  3960
gtgagtata  gaatgtgtt  cacatgtcc  cagtattgg  gagataatt  cataattca  4020
ataccttta  tcatctttc  agaaagagg  tcctcccat  caaccaccc  agagaactg  4080
ctttgttaa  tagttattt  aagactcat  catatcaaa  catgacttt  aaaggtctt  4140
gaggctggg  ctctgtaat  aattagttt  aaagccaag  tcataacat  aattgatgg  4200
caatttccc  tcagcagaa  gaaaaggtg  tttagatca  tagctcttt  gaaggttgt  4260
gctgacctg  tcataccgt  tcgcctcat  gctagtgtg  cgttgaaag  gtagcgact  4320
ggaagatac  acttacaca  tggggccta  tgttctttc  agaaccctt  ttttagctt  4380
tagaaccca  gggtccagt  tagtaacga  tgatttagg  aatcaatga  aggtttata  4440
tcttagatt  ttccagcaa  gtgtggatt  cattgttag  aagaacatt  ggtgggaat  4500
aacactcct  ggcataccg  tgacttttg  cccttgttc  cggtgtagg  gacccaagg  4560
atcttgaat  ccatctata  gaacacaat  ttccagcat  cgtttgctt  ttcagaaac  4620
ctagcattc  ctttaaata  tgacgcaat  cttaatgga  aagagattt  atgaagcaa  4680
ttatgtatt  caatagttc  tctattttt  gtgtccaaa  tttactaat  cagaagctt  4740
acaagcatg  cctcaccct  cccaccaca  aaacacatg  acacacacc  aagccacaa  4800
aaatcccaa  agagcagaa  cgaattttt  aaagattta  cgtgaggac  gcatttcca  4860
tcactaatt  tggctcaaa  ttatgaggc  ggaaatagg  gccaacagt  aatggggga  4920
gcctcctga  accagcaga  gaattttgt  cccaggcga  gacttcttg  acttctgcg  4980
atctccgtt  gatctcttt  acctttatt  catcttcat  agaatgaga  aggctcaaa  5040
ggaagcact  ttagaaatc  tctctgacc  agaagaatc  atccaaatc  ctgccttcc  5100
ctctgaacc  acagttccc  tctctgaca  ggggccatc  tctatcttc  atccagcgg  5160
tcttccttt  aggaaggct  tggtgcaga  cacttcaaa  atgtcctca  gccagatac  5220
gattgctag  agagagaca  ccggcaccc  gtccgaagc  ctccctcaa  ggaccggct  5280
atggcgttg  tcactggca  gctcagaga  attctactg  gggcgcagg  agcccggcc  5340
cccatgcag  catgactgg  tgcgccccc  tctcggggg  ttgctgcac  gcttgttta  5400
tgaattttg  tacttagaa  ggcaacatt  actttgtgt  ccattcatt  tttaaaaat  5460
ttccaaagc  cggcagtgt  tgaaagaaa  aactgggaa  gatacttgg  ttctgttaa  5520
ttttgtgtt  cttgcttaa  tgattaaag  cagtgcttg  agccaagcc  tcatgccac  5580
aacatgctc  acagcctgc  ctttgctct  ctgctcaca  tgaccaaga  tgccgcgtg  5640
ttggcctac  gaggtgaaa  gacaattga  tgacaggtg  gcaaaggga  aacttcccc  5700
tcttggtgc  aggaaagtc  caaatttaa  aatgttgct  ccagcccag  tcctaaatg  5760
tagttctca  cagctgcgt  gcttaccgt  cgccatttc  accaccgcc  gctgccagc  5820
ccgctacag  tcacagaga  gtgaacaga  aatggaaag  actcttagc  ttgcagtgg  5880
ctacatttt  taggaacca  tatttcagc  ttctttatt  cccggcacg  tgtgtcctt  5940
gcagagttc  agtttatgt  actgccagg  tcagacagt  atttgctgc  gctgctgct  6000
ctgctgctg  ttctcgaac  ggatgcatt  ggaagctgc  gtctgagtg  aggaatgtc  6060
tgctaagaa  gcaatgtct  ccttcatcc  tttctttct  ccctctgcg  gtccttgtt  6120
ttgtgtaat  cgggagagg  ttagagcta  agagattat  tatacacta  ccgtgcaca  6180
tatatatat  tagatatac  cctatcatg  cagagatct  catgtcagt  tttcagcaa  6240
taaggtgcc  catgttctg  gttcagcag  tataggaac  aagccgccc  ctcctgcac  6300
tgatgctcc  acctttgtt  tgcctcact  aaaatggtg  ttttttcag  tgtctgtct  6360
ttcttatgt  tttatttgt  aggtgctgt  tataagttg  atatattat  cacatatcc  6420
acccaatgg  tagaacaaa  agttgttaa  actgtaata  aatgtatag  tgataccaa  6480
tttaacaga  atggcatag  atttgtgaa  gcctatgtg  tttgtcctc  tttgtaagg  6540
aatttgcaa  tggatgcat  cagattaaa  tctatgtag  ttattttcc  attaaatat  6600
aatattata  cacaagaga  agaagtgtg  acaaacaag  aacagttta  gaccagcgt  6660
tatatagca  tggaaagtt  catctttgc  gtgaaaaca  tttaaagaa  atacttttt  6720
aaaaatccc  cagcttttt  gttgccact  gacgcttct  attttaatc  ttttagtaa  6780
gctcagctg  accagtgtt  gttatattt  agtcagaaa  atgttgttt  tcaacttgc  6840
ttataatct  ctgcatcta  ctcctgctg  agcatcayg  aggtgtcag  caacagtga  6900
aagtgcaca  ttttgttgt  gcagaaact  tgtcagagg  ataagtaaa  cagcctgca  6960
cagaagact  tgttcagct  cagaggcat  tgtgaccgt  tgtgtccaa  tctctctgt  7020
cctttttct  ttacaaact  aagctgtgg  gccaatgaa  taacagtag  gattgtagg  7080
aaagaatac  tcaggaaaa  caaatacac  tacaagaag  ccctgttct  agaaaatgt  7140
tttagttat  ggttagcac  agaagagac  tggctgtca  ccagccaag  gaaggacct  7200
tcatccatt  ccattcatg  cccatcata  tacggacmc  aaaagcaaa  tcggttttg  7260
catcagtta  aaattacgt  ttggattgt  tattgttac  tctctcttc  agcttagtt  7320
ttagtgtct  attgtgacc  ctgcattta  cttcaaata  cctaatttt  aaacaaaag  7380
acaagaaaa  tttataaca  catgttcac  aaaaccacg  ttgaatctt  ggtgtgggc  7440
tcctttcga  tgttgtcca  aagagcagt  cgtggaatt  tgcccatct  acccatatt  7500
tcagcttat  ctgccacca  agtagagtc  aataaattc  aaagttttt  tttgctcca  7560
ggtgtatgt  ctgactttg  aaatgtcag  ttctataat  ataccccta  catccagga  7620
acaaatgac  gattatctt  aaactgaaa  tgactctac  atgcaaccc  taatgctga  7680
tggattaaa  aagtcagcc  ttttagtat  tgtttgaaa  ggccgtaaa  agttgacac  7740
tttgttgtt  tggatcctg  gtgtctaga  ccacgtgtt  tttccatcg  atactgtag  7800
gtgcacccc  tgggattca  cattaagaa  tgaggctca  tgttgtcag  aacaaagct  7860
ccacccccc  ggttcaacc  tgtgggaga  ctgttgagc  tgagaatgt  ctagactca  7920
aggtactaa  atttgttac  acatcattg  ttcctttct  caggacgaa  tgaggctta  7980
actttactg  taatgatac  ggttcattt  aatgtgctt  ttggtatgt  gctattttt  8040
atttcatag  tttcaaaaa  catgctaat  gtatacttg  ctagtttaa  gctatttta  8100
aatatgtac  atactattc  cagcattta  ttcgtttaa  ttttattat  aagcaatct  8160
ctaaaaaag  acaactgta  ttgaacttt  caatagttg  ttgtgagct  tgataatca  8220
aagtcatta  agtcttttt  aacaaacat  cgtgcttac  tttcaacat  attcccagt  8280
atatacaga  aaagatttc  acctgtcac  tatctgcct  ttttacctg  gcaatggtg  8340
agttcttag  cctaaggtc  gtaattgca  tacttttaa  gaaagatgt  gctctaagt  8400
ctgtttgtt  gttatgaaa  cagattttt  tgcttgttc  taatgctgt  gtcaaacca  8460
agcacaaaa  cattaaaaa  aatcagcgg  atac  8494



<210> 5507
<211> 306
<212> PRT
<213> Homo sapiens
<308> O15165
<400> 5507

Met Pro Glu Ala Gly Phe Gln Ala Thr Asn Ala Phe Thr Glu Cys Lys 
  1               5                  10                  15
Phe Thr Cys Thr Ser Gly Lys Cys Leu Tyr Leu Gly Ser Leu Val Cys 
             20                  25                  30
Asn Gln Gln Asn Asp Cys Gly Asp Asn Ser Asp Glu Glu Asn Cys Leu 
         35                  40                  45
Leu Val Thr Glu His Pro Pro Pro Gly Ile Phe Asn Ser Glu Leu Glu 
     50                  55                  60
Phe Ala Gln Ile Ile Ile Ile Val Val Val Val Thr Val Met Val Val 
 65                  70                  75                  80
Val Ile Val Cys Leu Leu Asn His Tyr Lys Val Ser Thr Arg Ser Phe 
                 85                  90                  95
Ile Asn Arg Pro Asn Gln Ser Arg Arg Arg Glu Asp Gly Leu Pro Gln 
             100                105                110
Glu Gly Cys Leu Trp Pro Ser Asp Ser Ala Ala Pro Arg Leu Gly Ala 
         115                120                125
Ser Glu Ile Met His Ala Pro Arg Ser Arg Asp Arg Phe Thr Ala Pro 
     130                135                140
Ser Phe Ile Gln Arg Asp Arg Phe Ser Arg Phe Gln Pro Thr Tyr Pro 
 145                150                155                160
Tyr Val Gln His Glu Ile Asp Leu Pro Pro Thr Ile Ser Leu Ser Asp 
                 165                170                175
Gly Glu Glu Pro Pro Pro Tyr Gln Gly Pro Cys Thr Leu Gln Leu Arg 
             180                185                190
Asp Pro Glu Gln Gln Met Glu Leu Asn Arg Glu Ser Val Arg Ala Pro 
         195                200                205
Pro Asn Arg Thr Ile Phe Asp Ser Asp Leu Ile Asp Ile Ala Met Tyr 
     210                215                220
Ser Gly Gly Pro Cys Pro Pro Ser Ser Asn Ser Gly Ile Ser Ala Ser 
 225                230                235                240
Thr Cys Ser Ser Asn Gly Arg Met Glu Gly Pro Pro Pro Thr Tyr Ser 
                 245                250                255
Glu Val Met Gly His His Pro Gly Ala Ser Phe Leu His His Gln Arg 
             260                265                270
Ser Asn Ala His Arg Gly Ser Arg Leu Gln Phe Gln Gln Asn Asn Ala 
         275                280                285
Glu Ser Thr Ile Val Pro Ile Lys Gly Lys Asp Arg Lys Pro Gly Asn 
     290                295                300
Leu Val 
 305



<210> 5508
<211> 616
<212> DNA
<213> Rattus norvegicus
<308> AA891734
<400> 5508

actctgaat  aggttgata  ttaaagagc  gaggaaatg  ctatacaaa  ggtttatgg  60
acattcatt  acatactgg  tatatattc  ttacaatat  gaatagtga  aactgcgct  120
atgggtaag  caggtacaa  aacattaca  cgtccttga  actgaggat  aatgcagtg  180
ggcttttaa  gtgggaaca  cccaacact  gaaactatg  gaccattaa  gagaaggtt  240
atgggaccc  ggttatata  ggaaagtgg  gggacatca  tgaatttac  caccgaaca  300
tgcactaac  tctgcccaa  tgatggcct  gaagcaaaa  cctgagcaa  actcctcct  360
agtgtttct  agtatagtc  atgacactg  tctcgtctt  ttctcttca  tacaaacgt  420
acacacaga  gacagaagt  tgccctacc  gctgttgta  acagttgta  agctgtctt  480
ctgtgtttc  tcagagtga  tcccttgac  cccttgact  cttttacct  gagtgaaga  540
catacctgg  cagccactt  aaaacgcat  cccatggct  cttggatgc  aacctctgt  600
gcattcaat  cactgg  616



<210> 5509
<211> 2622
<212> DNA
<213> Homo sapiens
<308> AK001539
<400> 5509

gaaacagca  agaacacga  gtggtcccc  tgtccctgg  acactagca  tccggggga  60
gaggaatcc  cagcccttg  ggcagaggt  ccgagtgac  gccatgctt  gcccgtccg  120
atgggcgct  ctgtccagc  gcacccgag  ccgggggtt  ccctcacct  ggtcttccc  180
agatggaga  gctaacgaa  ctgagaagg  ggcgtatct  gacgaaggt  tgtgcaagt  240
aggcccttc  ggaacacag  agggcctac  acgaggggc  tttgcgatg  gctgtgagg  300
tgggggtgg  gggaagaat  ggccacgtt  gagacccca  gccacccca  catggtgag  360
gctctgtgc  tcctgctca  ctgtggtga  ctgggcgag  tgggcgagc  gggcgagct  420
ggctgggga  agcctgtga  gaccgagag  agaaatgag  agaaggaac  aaaatatta  480
ttctatgta  tttatattt  acttatgcc  aattattta  gataatttg  cattgctat  540
ctgtaccag  gtcaaatgc  gcagcctgc  aagctgtga  tttgtgagg  ttgtcccta  600
gtaggatgc  ccgcaggcc  ctggccact  aaagagtgt  cagtggact  tgggtctcc  660
atatgcggt  ccgcccaaa  gtggctttg  ctcaagcaa  ctaccctga  gttttactc  720
ttggaatgt  tttccccga  tgtggatga  ttcttttct  atggagaga  tccaggagg  780
atggaaaac  cctggattt  agctcagca  cccccacat  ggcttttcg  tcatcttca  840
gcctgaagc  gcacgacct  aagttcgcc  gcatttatc  gccctcttt  tgctgctcc  900
tgccacctt  gggttcctg  tggggacca  gtgtggttg  ggcgtgtgt  agcagaagg  960
aggatgagg  aaaagagaa  aaaccccgg  actgacaag  tgtttttga  tgccactgt  1020
tgccatcat  taagccact  aatcaagtg  atttcaggc  tatttcaac  ttccaatgc  1080
ctggttttc  tgcttgaat  tgttcgtgg  caaaggttt  ggggaattt  tgaccctgg  1140
acatcccca  agtgaaaga  ggagctggg  cacttcaga  taaggcctt  gccccatcc  1200
ctcacagcc  aggtgctct  caggcatgc  gactgtcct  attgcgatc  agcccgaaa  1260
tccctcctc  gctttcaaa  gtcaaatcc  ccattctta  gccacactg  tgtcacaag  1320
tcctgtcag  gagctgggg  ttgggaatg  gctttgtga  ctctgcttt  aagtgaggg  1380
ccgaggaaa  cttagaaac  ggcagagtt  gaagcagcc  aatcacagt  ggtgttgtg  1440
gtgtgtgcg  gtgtgcatg  gtgcgtgta  gcgtgtgtg  aagcaggtg  accattcca  1500
tttttagct  ctattgatg  accaaacca  gtgcctcat  tctgtgcca  atgtttgcc  1560
tggtcgttg  ggacctcct  ctctaactt  cggtggcat  actgtcagg  ggtgctggc  1620
ttttcagca  atcctcatg  gttgaccct  atgtcttta  cagaggcct  tagcatctc  1680
gtttttcat  cactgcagg  atgtggcca  agggagcag  ggtttgtac  ttccccaag  1740
ggtcctcat  ctgagacgg  ctctaccca  gtttaaccc  aagagtgca  gccaggttc  1800
ttatccttc  gatgaagga  gggagagct  atttagaag  cagagcaaa  tagggtctc  1860
gtattgaga  acgcagcct  ccagggaat  acagagaca  cggggtgcc  gtgatggcc  1920
tcatgaagc  atgcctcga  ggcattcag  aagccctgc  aacgtgctt  ttgaactca  1980
tggccaggt  tgattttta  acaaggtaa  cgtggtcaa  ggcatcggg  aatttgctc  2040
aagcagata  ctccctctg  ggaaccaaa  gaagcaagt  tccacgatt  ctgaagagc  2100
ggtatagga  gtttctttc  tccttttgt  ttacatgtg  attaaacag  acaagctgt  2160
tgtcatcac  gattgtact  tgggctcag  aaccgtgag  gagccccca  cgtggacac  2220
ggctctagg  ccacaggaa  aggaacgtt  ccaggcatt  tgtctccag  gctcccgct  2280
gacaggcac  tactgccct  gggagtaaa  gcggagagt  cacgaactg  gcccaacgc  2340
tgttatagc  agggtccta  taactactc  gtaaaagaa  gtattgttg  attcctcca  2400
tgttaagct  tagccatgt  aaaagtcac  gtgcattta  tctcagcat  aaatacctt  2460
taacgtctt  tctgccttg  tagtgcata  ttttacttt  ctgatactg  aaagaatat  2520
tccagtatg  aaatgaatg  tctataaat  ttttgtata  tcattttct  tgctcctta  2580
atatcatct  tattcagag  ataataaaa  tatgaactt  gt  2622



<210> 5510
<211> 516
<212> DNA
<213> Rattus norvegicus
<308> AA891735
<400> 5510

aatacaagt  aaagggggc  gggcaactc  ttccccctc  aggtcagga  caggagaat  60
tgctgggct  tccccggga  caaagagga  aagagtgac  tagaaactg  agcaaagga  120
gcttagtca  actcaggtg  gggtgacag  tcctcctgg  ttttgtttc  atttattaa  180
aaaaaaaag  aaagaaaga  agaaaaagc  accccctca  tcccagccc  ttcctcaca  240
ccagggtca  aaagcagca  cagtgaggc  ggttcctca  ctctggtta  ctctggccc  300
ggtcagctt  agccacctg  cctcaccag  agagggttt  agttggcag  taggcttgg  360
gaagtctct  cctggaccc  ccagaggcc  gggagcacc  ccctcctcc  aggaaaggg  420
atgcagtgt  tactgggct  agaggggtg  cctcaccca  ctgacatga  tcctgattc  480
cccatctcg  ggacggcag  aagtttatt  caccag  516



<210> 5511
<211> 558
<212> DNA
<213> Rattus norvegicus
<308> AA891737
<400> 5511

aaatggttc  gaatcactg  gaggctttt  gatgttccc  ttattcaaa  aacccaaat  60
aaaaacata  aactcacat  ttaagtaat  taagcaaaa  aaaaattat  tttaacaat  120
ccttatatt  tgttttagt  ttctactat  gacacataa  aataattat  tccattttc  180
gcttccctc  aaactataa  atgctgtta  atatttttg  aaaatcaaa  tccttcata  240
cctttcatc  attttatgt  gaaaagaga  ttattttga  gcactggaa  tagtgttgg  300
aaaataggt  tagagtcca  agctggtgt  tttgcgaat  agaacacaa  ctgacaagt  360
atttaaatt  cttagaaac  ttcacagtt  tccatatgt  catgtggca  aaggatgaa  420
tgccagcca  tatacatca  tgatcagtt  cttacattt  aaagatcaa  acacttggt  480
ggaagccta  aaggaaaca  ttaaagaca  ataattaag  actcttatc  ctgaaaagc  540
aagtccaca  tttagtta  558



<210> 5512
<211> 558
<212> DNA
<213> Rattus norvegicus
<308> AA891737
<400> 5512

aaatggttc  gaatcactg  gaggctttt  gatgttccc  ttattcaaa  aacccaaat  60
aaaaacata  aactcacat  ttaagtaat  taagcaaaa  aaaaattat  tttaacaat  120
ccttatatt  tgttttagt  ttctactat  gacacataa  aataattat  tccattttc  180
gcttccctc  aaactataa  atgctgtta  atatttttg  aaaatcaaa  tccttcata  240
cctttcatc  attttatgt  gaaaagaga  ttattttga  gcactggaa  tagtgttgg  300
aaaataggt  tagagtcca  agctggtgt  tttgcgaat  agaacacaa  ctgacaagt  360
atttaaatt  cttagaaac  ttcacagtt  tccatatgt  catgtggca  aaggatgaa  420
tgccagcca  tatacatca  tgatcagtt  cttacattt  aaagatcaa  acacttggt  480
ggaagccta  aaggaaaca  ttaaagaca  ataattaag  actcttatc  ctgaaaagc  540
aagtccaca  tttagtta  558



<210> 5513
<211> 593
<212> DNA
<213> Rattus norvegicus
<308> AA891738
<400> 5513

ccagtcata  tcttaaaca  acactttat  ggaatcgtt  taaaagcac  ctaagaggg  60
aatctcctt  catcccaga  gcgattgaa  gttgtagac  ggcagtggc  gcacatgcc  120
ttaatcccc  gattctgga  actaaggca  gcagtttgg  ctacaaagt  agttccagg  180
cagccaggg  tacacagag  aaccctgtc  tgaagggaa  aaaaacaag  tgatgaaga  240
gaaaaagaa  taacgtaca  tttttacac  ttccataca  cacacacat  tctgaagaa  300
ctaagcaat  caaaacaag  cctgagggg  ggcatgaga  gtaaaggta  ggtagggta  360
gaaagtgat  tcttcagag  tgctttctc  cctcagtag  ggaaggaaa  gtttatcta  420
ggcaccgag  attaaggct  ggttggtaa  gaggtgtag  ggtcctttg  gtacaaact  480
ctgttccat  ctttcatgg  accacctga  cgtggacac  gtgccaggc  ttgctgagc  540
cgcctcgaa  gttccagat  ggggccaca  tgtctggct  cacattgta  ctg  593



<210> 5514
<211> 488
<212> PRT
<213> Rattus norvegicus
<308> Q07116
<400> 5514

Met Gly Thr Leu Ile Gly Leu Gly Ala Val Leu Ala Tyr His Asp His 
  1               5                  10                  15
Arg Cys Arg Ala Ser Gln Glu Ser Pro Arg Ile Tyr Ser Lys Glu Asp 
             20                  25                  30
Val Arg Ser His Asn Asn Leu Gln Thr Gly Val Trp Val Thr Leu Gly 
         35                  40                  45
Ser Glu Val Phe Asp Val Thr Lys Phe Val Asp Leu His Pro Gly Gly 
     50                  55                  60
Gln Ser Lys Leu Met Leu Ala Ala Gly Gly Pro Leu Glu Pro Phe Trp 
 65                  70                  75                  80
Ala Leu Tyr Ala Val His Asn Gln Pro His Val Arg Glu Leu Leu Ala 
                 85                  90                  95
Glu Tyr Lys Ile Gly Glu Leu Asn Pro Glu Asp Arg Met Ser Pro Pro 
             100                105                110
Leu Glu Ala Ser Asp Pro Tyr Ser Asn Asp Pro Met Arg His Pro Ala 
         115                120                125
Leu Arg Ile Asn Ser Gln Arg Pro Phe Asn Ala Glu Pro Pro Pro Glu 
     130                135                140
Leu Leu Thr Glu Ser Tyr Ile Thr Pro Asn Pro Ile Phe Phe Thr Arg 
 145                150                155                160
Asn His Leu Pro Val Pro Asn Leu Asp Pro Asp Thr Tyr Arg Leu His 
                 165                170                175
Val Val Gly Ala Pro Gly Gly Gln Ser Leu Ser Leu Ser Leu Asp Asp 
             180                185                190
Leu His Lys Phe Pro Lys His Glu Val Thr Val Thr Leu Gln Cys Ala 
         195                200                205
Gly Asn Arg Arg Ser Glu Met Asn Lys Val Lys Glu Val Lys Gly Leu 
     210                215                220
Glu Trp Arg Thr Gly Ala Ile Ser Thr Ala Arg Trp Ala Gly Ala Arg 
 225                230                235                240
Leu Cys Asp Val Leu Ala Gln Ala Gly His Arg Leu Arg Glu Thr Glu 
                 245                250                255
Ala His Val Cys Phe Glu Gly Leu Asp Ser Asp Pro Thr Gly Thr Ala 
             260                265                270
Tyr Gly Ala Ser Ile Pro Leu Ala Arg Ala Met Asp Pro Gln Ala Glu 
         275                280                285
Val Leu Leu Ala Tyr Glu Met Asn Gly Gln Pro Leu Pro Arg Asp His 
     290                295                300
Gly Phe Pro Val Arg Val Val Val Pro Gly Val Val Gly Ala Arg His 
 305                310                315                320
Val Lys Trp Leu Gly Arg Val Ser Val Glu Ser Glu Glu Ser Tyr Ser 
                 325                330                335
His Trp Gln Arg Arg Asp Tyr Lys Gly Phe Ser Pro Ser Val Asp Trp 
             340                345                350
Asp Thr Val Asp Phe Asp Leu Ala Pro Ser Ile Gln Glu Leu Pro Ile 
         355                360                365
Gln Ser Ala Ile Thr Gln Pro Gln Asp Gly Thr Thr Val Glu Ser Gly 
     370                375                380
Glu Val Ile Ile Lys Gly Tyr Ala Trp Ser Gly Gly Gly Arg Ala Val 
 385                390                395                400
Ile Arg Val Asp Val Ser Met Asp Gly Gly Leu Thr Trp Gln Glu Ala 
                 405                410                415
Glu Leu Glu Gly Glu Glu Gln His Pro Arg Lys Ala Trp Ala Trp Arg 
             420                425                430
Ile Trp Gln Leu Lys Ala His Val Pro Ala Glu Gln Lys Glu Leu Asn 
         435                440                445
Ile Ile Cys Lys Ala Val Asp Asp Ser Tyr Asn Val Gln Pro Asp Thr 
     450                455                460
Val Ala Pro Ile Trp Asn Leu Arg Gly Val Leu Ser Asn Ala Trp His 
 465                470                475                480
Arg Val His Val Gln Val Val Pro 
                 485



<210> 5515
<211> 2408
<212> DNA
<213> Homo sapiens
<308> L31573
<400> 5515

ggaattccg  gtaatatag  gtttggtgc  atctgtggt  tcaaacatc  actgggggt  60
gtagaacat  tccccagtg  ataaggggg  actactgta  ttgttggct  ttcatgtta  120
ctctgctag  cagatgtca  ttcagagaa  aggaagcaa  ttcagaacg  cttggaatc  180
tgctcagga  atcgggctg  ttaatgaat  acaagagat  cagtttcac  aacccaagg  240
attttgccc  cagaatctg  gcttcttca  ccatttagg  tgtcactac  ttttttcac  300
tttttatcc  tgtttaagt  agtctgacc  acagttgtc  tctgctgac  tcagaaata  360
taatctggc  agtagacat  tggtttcgg  cctttaggc  cttcgcccc  ggcatcgtt  420
tctatggtg  acaaagttc  gaatggaag  tgggagaaa  gtgattctg  ttctagaag  480
acccatccc  cctacccca  tccccaccc  cattacctg  catcctgtc  gcacagtct  540
ctctgaagt  ctccaagtt  tctctaagg  cccatttgg  ctcccactc  caagactcc  600
cacttgccc  gaaagctcc  tgctgacct  ctctgtgtc  tcctctcac  cattccctt  660
ggcctccct  atatcccct  ccagggtct  cctatcttg  tcccagaat  ttccttcta  720
aggtctgct  caatgctgc  gctgcacag  gctgtggtc  tcaggctcc  acaggcctg  780
agactcaag  caatcccct  aaggatctg  attcaggcc  gctccacaa  tgattcatt  840
cagccccag  gccccagcc  caccttctc  ggtgataac  ccagcaccc  gggatggag  900
gtcatgggg  ccctattag  tctcggtgc  gtgttggcc  atcaggacc  tcggtgtag  960
gctgctcag  agtcaacac  catatacac  aaggaggaa  tgagttccc  caccagccc  1020
gagactggg  tctgggtga  tctgggctc  gaggtcttt  atgtcacag  atttgtgga  1080
ctacatcca  gggggcctt  aaagctgat  ctagcagct  ggggtcccc  agagccctt  1140
tgggccctc  atgctgttc  caaccagtc  catgtgcgt  agttactgg  tcagtacaa  1200
attggggag  tgaatcctg  agacaaggt  gcccccacc  tggagacct  tgaccctta  1260
gctgatgat  ctgtacgtc  cccagccct  aaggtcaac  gccagcggc  ctttaatgc  1320
gagcctccc  ctgagctgc  gacagaaaa  tacatcaca  ccaacccta  cttcttcac  1380
cggaaccat  tgcctgtac  taacctgga  ccagacacc  atcgcttac  cgtagtagg  1440
gcacctggg  gtcagtcac  gtctctttc  ctggatgac  tgcacaact  tcccaggta  1500
gagatcaca  tcactctgc  gtgtgccgg  aaccgacgc  ctgagatga  tcaggtcaa  1560
gaagtaaaa  gtctggagt  gagaacagg  gccatcagc  ctgcacgct  ggctggggc  1620
cggctctgt  atgtgttag  ccaggctgg  caccaactc  gtgaaactg  ggcccacgt  1680
tgctttgag  gactggact  agaccctac  gggactgcc  atggagcat  catccctct  1740
gctcgggcc  tggaccctg  agctgaggt  ctgctggca  atgagatga  tgggcagcc  1800
ctgccacgt  accacggct  ccctgtgcg  gtggtggtt  ctggagtgg  gggtgcccg  1860
catgtcaaa  ggctgggca  agtgagtgt  cagccagag  aaagttaca  ccactggca  1920
cggcgggat  acaaaggct  ctctccatc  gtggactgg  agactgtag  ttttgactc  1980
gctccatcc  ttcaggaac  tcctgtcca  tccgccatc  cagagcccc  ggatggaga  2040
actgtagaa  caggggagg  gaccatcaa  ggctatgca  ggagtggtg  tggcagggc  2100
gtgatccgg  tggatgtgt  tctggatgg  ggcctaacc  ggcaggtgg  taagctgga  2160
ggagaggaa  agcgcccca  gaaggcctg  gcatggcgt  tgtggcagt  gaaagcccc  2220
gtgccagct  gacaaaagg  actgaacat  gtttgtaag  ctgtggatg  tggttacaa  2280
gtgcagcca  acaccgtgg  cccaatctg  aacctgcga  gtgttctca  caatgcctg  2340
catcgtgtc  atgtctatg  ctccccatg  gcatggaaa  gagccacct  caccccttt  2400
cggaattc  2408



<210> 5516
<211> 488
<212> PRT
<213> Homo sapiens
<308> P51687
<400> 5516

Met Gly Thr Leu Leu Gly Leu Gly Ala Val Leu Ala Tyr Gln Asp His 
  1               5                  10                  15
Arg Cys Arg Ala Ala Gln Glu Ser Thr His Ile Tyr Thr Lys Glu Glu 
             20                  25                  30
Val Ser Ser His Thr Ser Pro Glu Thr Gly Ile Trp Val Thr Leu Gly 
         35                  40                  45
Ser Glu Val Phe Asp Val Thr Glu Phe Val Asp Leu His Pro Gly Gly 
     50                  55                  60
Pro Ser Lys Leu Met Leu Ala Ala Gly Gly Pro Leu Glu Pro Phe Trp 
 65                  70                  75                  80
Ala Leu Tyr Ala Val His Asn Gln Ser His Val Arg Glu Leu Leu Ala 
                 85                  90                  95
Gln Tyr Lys Ile Gly Glu Leu Asn Pro Glu Asp Lys Val Ala Pro Thr 
             100                105                110
Val Glu Thr Ser Asp Pro Tyr Ala Asp Asp Pro Val Arg His Pro Ala 
         115                120                125
Leu Lys Val Asn Ser Gln Arg Pro Phe Asn Ala Glu Pro Pro Pro Glu 
     130                135                140
Leu Leu Thr Glu Asn Tyr Ile Thr Pro Asn Pro Ile Phe Phe Thr Arg 
 145                150                155                160
Asn His Leu Pro Val Pro Asn Leu Asp Pro Asp Thr Tyr Arg Leu His 
                 165                170                175
Val Val Gly Ala Pro Gly Gly Gln Ser Leu Ser Leu Ser Leu Asp Asp 
             180                185                190
Leu His Asn Phe Pro Arg Tyr Glu Ile Thr Val Thr Leu Gln Cys Ala 
         195                200                205
Gly Asn Arg Arg Ser Glu Met Thr Gln Val Lys Glu Val Lys Gly Leu 
     210                215                220
Glu Trp Arg Thr Gly Ala Ile Ser Thr Ala Arg Trp Ala Gly Ala Arg 
 225                230                235                240
Leu Cys Asp Val Leu Ala Gln Ala Gly His Gln Leu Cys Glu Thr Glu 
                 245                250                255
Ala His Val Cys Phe Glu Gly Leu Asp Ser Asp Pro Thr Gly Thr Ala 
             260                265                270
Tyr Gly Ala Ser Ile Pro Leu Ala Arg Ala Met Asp Pro Glu Ala Glu 
         275                280                285
Val Leu Leu Ala Tyr Glu Met Asn Gly Gln Pro Leu Pro Arg Asp His 
     290                295                300
Gly Phe Pro Val Arg Val Val Val Pro Gly Val Val Gly Ala Arg His 
 305                310                315                320
Val Lys Trp Leu Gly Arg Val Ser Val Gln Pro Glu Glu Ser Tyr Ser 
                 325                330                335
His Trp Gln Arg Arg Asp Tyr Lys Gly Phe Ser Pro Ser Val Asp Trp 
             340                345                350
Glu Thr Val Asp Phe Asp Ser Ala Pro Ser Ile Gln Glu Leu Pro Val 
         355                360                365
Gln Ser Ala Ile Thr Glu Pro Arg Asp Gly Glu Thr Val Glu Ser Gly 
     370                375                380
Glu Val Thr Ile Lys Gly Tyr Ala Trp Ser Gly Gly Gly Arg Ala Val 
 385                390                395                400
Ile Arg Val Asp Val Ser Leu Asp Gly Gly Leu Thr Trp Gln Val Ala 
                 405                410                415
Lys Leu Asp Gly Glu Glu Gln Arg Pro Arg Lys Ala Trp Ala Trp Arg 
             420                425                430
Leu Trp Gln Leu Lys Ala Pro Val Pro Ala Gly Gln Lys Glu Leu Asn 
         435                440                445
Ile Val Cys Lys Ala Val Asp Asp Gly Tyr Asn Val Gln Pro Asp Thr 
     450                455                460
Val Ala Pro Ile Trp Asn Leu Arg Gly Val Leu Ser Asn Ala Trp His 
 465                470                475                480
Arg Val His Val Tyr Val Ser Pro 
                 485



<210> 5517
<211> 511
<212> DNA
<213> Rattus norvegicus
<308> AA891740
<400> 5517

ccagattaa  aaattcata  ttatgcaaa  gaagcgggg  ataagtgac  gcaacgagg  60
tccaggcag  ggtcaacac  gggttgtca  agggtggtg  agccgctgt  tcccatcag  120
aacgaggcc  cgcccaccg  catcagggc  cctccccca  ggcatgggg  ccccggggc  180
atgacatca  catcctcct  agtttccac  cccttggtc  gaggccgga  gacatcatc  240
tctttgtcc  gctctggga  cgtagggac  gcagcctga  aatctgcga  ccaagcctg  300
aagttccca  gatgtttct  gaagaggcc  gggaaggag  cgcgggggt  ggggacacc  360
ggcagcagg  cttccttca  cctgcgcat  cgcagcagg  ccaggagca  caccagggt  420
agcagggcc  ccggaggcc  caggccagg  cgagaggtg  ggtgggggt  ccgggggtc  480
tcgggaggg  ggggccagt  cangagcct  t  511



<210> 5518
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> NP_057924
<400> 5518

Met Ala Trp Ala Leu Ala Val Ile Leu Leu Pro Arg Leu Leu Thr Ala 
  1               5                  10                  15
Ala Ala Ala Ala Ala Ala Val Thr Ser Arg Gly Asp Val Thr Val Val 
             20                  25                  30
Cys His Asp Leu Glu Thr Val Glu Val Thr Trp Gly Ser Gly Pro Asp 
         35                  40                  45
His His Gly Ala Asn Leu Ser Leu Glu Phe Arg Tyr Gly Thr Gly Ala 
     50                  55                  60
Leu Gln Pro Cys Pro Arg Tyr Phe Leu Ser Gly Ala Gly Val Thr Ser 
 65                  70                  75                  80
Gly Cys Ile Leu Pro Ala Ala Arg Ala Gly Leu Leu Glu Leu Ala Leu 
                 85                  90                  95
Arg Asp Gly Gly Gly Ala Met Val Phe Lys Ala Arg Gln Arg Ala Ser 
             100                105                110
Ala Trp Leu Lys Pro Arg Pro Pro Trp Asn Val Thr Leu Leu Trp Thr 
         115                120                125
Pro Asp Gly Asp Val Thr Val Ser Trp Pro Ala His Ser Tyr Leu Gly 
     130                135                140
Leu Asp Tyr Glu Val Gln His Arg Glu Ser Asn Asp Asp Glu Asp Ala 
 145                150                155                160
Trp Gln Thr Thr Ser Gly Pro Cys Cys Asp Leu Thr Val Gly Gly Leu 
                 165                170                175
Asp Pro Ala Arg Cys Tyr Asp Phe Arg Val Arg Ala Ser Pro Arg Ala 
             180                185                190
Ala His Tyr Gly Leu Glu Ala Gln Pro Ser Glu Trp Thr Ala Val Thr 
         195                200                205
Arg Leu Ser Gly Ala Ala Ser Ala Ala Ser Cys Thr Ala Ser Pro Ala 
     210                215                220
Pro Ser Pro Ala Leu Ala Pro Pro Leu Leu Pro Leu Gly Cys Gly Leu 
 225                230                235                240
Ala Ala Leu Leu Thr Leu Ser Leu Leu Leu Ala Ala Leu Arg Leu Arg 
                 245                250                255
Arg Val Lys Asp Ala Leu Leu Pro Cys Val Pro Asp Pro Ser Gly Ser 
             260                265                270
Phe Pro Gly Leu Phe Glu Lys His His Gly Asn Phe Gln Ala Trp Ile 
         275                280                285
Ala Asp Ala Gln Ala Thr Ala Pro Pro Ala Arg Thr Glu Glu Glu Asp 
     290                295                300
Asp Leu Ile His Pro Lys Ala Lys Arg Val Glu Pro Glu Asp Gly Thr 
 305                310                315                320
Ser Leu Cys Thr Val Pro Arg Pro Pro Ser Phe Glu Pro Arg Gly Pro 
                 325                330                335
Gly Gly Gly Ala Met Val Ser Val Gly Gly Ala Thr Phe Met Val Gly 
             340                345                350
Asp Ser Gly Tyr Met Thr Leu 
         355



<210> 5519
<211> 608
<212> DNA
<213> Rattus norvegicus
<308> AA891746
<400> 5519

cactttcca  ggttttgct  tgtttgaca  cagttatgg  ttgaggggg  acacaggcc  60
gacccccat  ttccgtttg  ccatgtgag  agacccacg  cagtgctgg  ggtcctggg  120
gaccagcca  aagagctca  ccggaacca  tggcttcga  gctttgtgt  catttcgcc  180
tcggcccct  ctcgatagg  ttcccgatg  ccttccccc  gagcttgag  ccgatggct  240
tctcaattt  gcccaaaac  tggttattc  gaatggccc  tccactttc  tagtctgcg  300
tgacttgcg  cttttcatt  attttcgtg  ccaggtcct  ctgcgtcag  cctttgctc  360
gccggcccc  ctggatcac  ttgcccacc  ccagggtca  cctgtcgtg  tgcagctcc  420
ctgtctccc  gtctagctt  gctgtgttt  tagtgatgg  atgctgctt  ttctggcca  480
cagcccatt  tttggatgt  tccacatct  ctcctcgtc  ctgagctgc  aagatggcc  540
gcttagact  ggcctgtgc  gccgtgggg  ccttcttgc  cagcaccgt  acggtgtcc  600
agtcactc  608



<210> 5520
<211> 148
<212> PRT
<213> Rattus norvegicus
<308> NP_067494
<400> 5520

Met Ala Glu Ser Asp Trp Asp Thr Val Thr Val Leu Arg Lys Lys Gly 
  1               5                  10                  15
Pro Thr Ala Ala Gln Ala Lys Ser Lys Gln Ala Ile Leu Ala Ala Gln 
             20                  25                  30
Arg Arg Gly Glu Asp Val Glu Thr Ser Lys Lys Trp Ala Ala Gly Gln 
         35                  40                  45
Asn Lys Gln His Ser Ile Thr Lys Asn Thr Ala Lys Leu Asp Arg Glu 
     50                  55                  60
Thr Glu Glu Leu His His Asp Arg Val Thr Leu Glu Val Gly Lys Val 
 65                  70                  75                  80
Ile Gln Arg Gly Arg Gln Ser Lys Gly Leu Thr Gln Lys Asp Leu Ala 
                 85                  90                  95
Thr Lys Ile Asn Glu Lys Pro Gln Val Ile Ala Asp Tyr Glu Ser Gly 
             100                105                110
Arg Ala Ile Pro Asn Asn Gln Val Leu Gly Lys Ile Glu Arg Ala Ile 
         115                120                125
Gly Leu Lys Leu Arg Gly Lys Asp Ile Gly Lys Pro Ile Glu Lys Gly 
     130                135                140
Pro Lys Ala Lys 
 145



<210> 5521
<211> 607
<212> DNA
<213> Homo sapiens
<308> AB002283
<400> 5521

ggcacgagc  ggacggacg  ttngttttt  gcccgccat  gccgagagc  actgggaca  60
ggtgacggt  ctgcgcaag  agggcccta  ggccgccca  gccaaatcc  agcaggcta  120
cttagcggc  cagagacga  gagaagatg  ggagacttc  aagaaatgg  ctgctggcc  180
gaacaaaca  cattctatt  ccaagaaca  ggccaagct  gaccgggag  cagaggagc  240
gcaccatga  agggtgacc  tggaggtgg  caaggtgat  cagcaaggt  ggcagagca  300
ggggcttac  cagaaggac  tggccacga  aatcaatga  aagccacag  tgatcgcgg  360
ctatgagag  ggacgggcc  tacccaata  ccaggtgct  ggcaaaatc  agcgggcca  420
tggcgagtg  ccctccacc  ttcgccggg  ccgctgaac  gggaggcta  ccgctccca  480
ctggggttg  tgagagtgg  actcggggg  agaagatgg  cctgggggt  ccctgttct  540
tgaattcga  ctcggtacc  ggggatcct  tagagtcga  ctgcaggca  gcaacctgc  600
tancatg  607



<210> 5522
<211> 140
<212> PRT
<213> Homo sapiens
<308> AB002283
<400> 5522

Met Ala Glu Ser Asp Trp Asp Thr Val Thr Val Leu Arg Lys Lys Gly 
  1               5                  10                  15
Pro Thr Ala Ala Gln Ala Lys Ser Lys Gln Ala Ile Leu Ala Ala Gln 
             20                  25                  30
Arg Arg Gly Glu Asp Val Glu Thr Ser Lys Lys Trp Ala Ala Gly Gln 
         35                  40                  45
Asn Lys Gln His Ser Ile Thr Lys Asn Thr Ala Lys Leu Asp Arg Glu 
     50                  55                  60
Thr Glu Glu Leu His His Asp Arg Val Thr Leu Glu Val Gly Lys Val 
 65                  70                  75                  80
Ile Gln Gln Gly Arg Gln Ser Lys Gly Leu Thr Gln Lys Asp Leu Ala 
                 85                  90                  95
Thr Lys Ile Asn Glu Lys Pro Gln Val Ile Ala Asp Tyr Glu Ser Gly 
             100                105                110
Arg Ala Ile Pro Asn Asn Gln Val Leu Gly Lys Ile Glu Arg Ala Ile 
         115                120                125
Gly Glu Cys Pro Ser Thr Leu Arg Arg Val Arg Ter 
     130                135                140



<210> 5523
<211> 569
<212> DNA
<213> Rattus norvegicus
<308> AA891751
<400> 5523

aacggtttc  gcaatccaa  gatttatta  acaattatg  cccaccctg  cccgatctc  60
tccctccca  tttctcctc  gtctctctt  agtatccgt  gctccctgt  ttccccaag  120
cgcaatagc  aaacgagca  tttcagctt  agaggtcgg  cgaaggacg  ggggtctga  180
aatgacttt  cagacgatg  gcacagcac  ttcgaggac  gcgagagca  gagagactc  240
ctgtttgtg  cgcacagac  tgaaaaaaa  acttgcatg  agcatggtt  tccagagag  300
tgctatata  tcttgtgtt  tcaatggag  agggtggtt  gagccatca  tatttggtt  360
gcagggtac  accactgga  gctttgtct  tctgtgaag  ttgttgtat  cttgcaagg  420
tccagggat  ggcctgacg  agacagcga  ggaccttct  ccattacat  acggacatc  480
cggatctct  ccttggata  aggatataa  ttgaagaaa  attctcctt  tccaagtgg  540
ataacatac  aaatgtagg  gaaaatttt  569



<210> 5524
<211> 1951
<212> PRT
<213> Rattus norvegicus
<308> NP_037251
<400> 5524

Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe Arg Leu 
  1               5                  10                  15
Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Ala Ala Glu Glu 
             20                  25                  30
Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp Ile Asp Asp Glu Asn Lys 
         35                  40                  45
Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
     50                  55                  60
Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
 65                  70                  75                  80
Asp Pro Tyr Tyr Val Ser Lys Lys Thr Phe Val Val Leu Asn Lys Gly 
                 85                  90                  95
Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
             100                105                110
Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
         115                120                125
Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
     130                135                140
Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
 145                150                155                160
Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg 
                 165                170                175
Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
             180                185                190
Leu Asp Phe Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Asp 
         195                200                205
Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
     210                215                220
Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
 225                230                235                240
Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                 245                250                255
Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
             260                265                270
Leu Arg Asn Lys Cys Ser Gln Trp Pro Pro Ser Asp Ser Ala Phe Glu 
         275                280                285
Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr Met Asp Ser Asn Gly Thr 
     290                295                300
Phe Val Asn Val Thr Met Ser Thr Phe Asn Trp Lys Asp Tyr Ile Ala 
 305                310                315                320
Asp Asp Ser His Phe Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu 
                 325                330                335
Cys Gly Asn Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys 
             340                345                350
Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr 
         355                360                365
Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr 
     370                375                380
Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr 
 385                390                395                400
Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val 
                 405                410                415
Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln 
             420                425                430
Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met 
         435                440                445
Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala 
     450                455                460
Ala Ser Ala Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu 
 465                470                475                480
Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala 
                 485                490                495
Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His Leu 
             500                505                510
Glu Gly Asn His Arg Ala Asp Gly Asp Arg Phe Pro Lys Ser Glu Ser 
         515                520                525
Glu Asp Ser Val Lys Arg Arg Ser Phe Leu Leu Ser Leu Asp Gly Asn 
     530                535                540
Pro Leu Thr Gly Asp Lys Lys Leu Cys Ser Pro His Gln Ser Leu Leu 
 545                550                555                560
Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser 
                 565                570                575
Ile Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp 
             580                585                590
Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Ser Arg Arg 
         595                600                605
Asp Ser Leu Phe Val Pro His Arg Pro Gly Glu Arg Arg Asn Ser Asn 
     610                615                620
Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser Tyr 
 625                630                635                640
Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly Arg Gln Arg Ser 
                 645                650                655
Met Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
             660                665                670
Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val Phe 
         675                680                685
Leu Ile Trp Asp Cys Cys Asp Ala Trp Leu Lys Val Lys His Leu Val 
     690                695                700
Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
 705                710                715                720
Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
                 725                730                735
Gln Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly 
             740                745                750
Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp Pro Tyr 
         755                760                765
Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Ile Ile Val Ser 
     770                775                780
Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
 785                790                795                800
Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
                 805                810                815
Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
             820                825                830
Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
         835                840                845
Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
     850                855                860
Lys Ile Asn Val Asp Cys Lys Leu Pro Arg Trp His Met Asn Asp Phe 
 865                870                875                880
Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
                 885                890                895
Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
             900                905                910
Ile Val Phe Met Leu Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
         915                920                925
Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
     930                935                940
Ala Thr Asp Asp Asp Asn Glu Met Asn Asn Leu Gln Ile Ala Val Gly 
 945                950                955                960
Arg Met Gln Lys Gly Ile Asp Phe Val Lys Asn Lys Ile Arg Glu Cys 
                 965                970                975
Phe Arg Lys Ala Phe Phe Arg Lys Pro Lys Val Ile Glu Ile Gln Glu 
             980                985                990
Gly Asn Lys Ile Asp Ser Cys Met Ser Asn Asn Thr Gly Ile Glu Ile 
         995                1000                1005
Ser Lys Glu Leu Asn Tyr Leu Lys Asp Gly Asn Gly Thr Thr Ser Gly 
     1010                1015                1020
Val Gly Thr Gly Ser Ser Val Glu Lys Tyr Val Ile Asp Glu Asn Asp 
 1025                1030                1035                1040
Tyr Met Ser Phe Ile Asn Asn Pro Ser Leu Thr Val Thr Val Pro Ile 
                 1045                1050                1055
Ala Val Gly Glu Ser Asp Phe Glu Asn Leu Asn Thr Glu Glu Phe Ser 
             1060                1065                1070
Ser Glu Ser Glu Leu Glu Glu Ser Lys Glu Lys Leu Asn Ala Thr Ser 
         1075                1080                1085
Ser Ser Glu Gly Ser Thr Val Asp Val Ala Pro Pro Arg Glu Gly Glu 
     1090                1095                1100
Gln Ala Glu Ile Glu Pro Glu Glu Asp Leu Lys Pro Glu Ala Cys Phe 
 1105                1110                1115                1120
Thr Glu Gly Cys Ile Lys Lys Phe Pro Phe Cys Gln Val Ser Thr Glu 
                 1125                1130                1135
Glu Gly Lys Gly Lys Ile Trp Trp Asn Leu Arg Lys Thr Cys Tyr Ser 
             1140                1145                1150
Ile Val Glu His Asn Trp Phe Glu Thr Phe Ile Val Phe Met Ile Leu 
         1155                1160                1165
Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu Gln Arg 
     1170                1175                1180
Lys Thr Ile Lys Thr Met Leu Glu Tyr Ala Asp Lys Val Phe Thr Tyr 
 1185                1190                1195                1200
Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Phe Gln 
                 1205                1210                1215
Thr Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile Val Asp 
             1220                1225                1230
Val Ser Leu Val Ser Leu Val Ala Asn Ala Leu Gly Tyr Ser Glu Leu 
         1235                1240                1245
Gly Ala Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg 
     1250                1255                1260
Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala Leu Val 
 1265                1270                1275                1280
Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile Phe 
                 1285                1290                1295
Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys Phe 
             1300                1305                1310
Tyr His Cys Val Asn Thr Thr Thr Gly Asn Met Phe Glu Ile Lys Glu 
         1315                1320                1325
Val Asn Asn Phe Ser Asp Cys Gln Ala Leu Gly Lys Gln Ala Arg Trp 
     1330                1335                1340
Lys Asn Val Lys Val Asn Phe Asp Asn Val Gly Ala Gly Tyr Leu Ala 
 1345                1350                1355                1360
Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp Ile Met Tyr Ala 
                 1365                1370                1375
Ala Val Asp Ser Arg Asp Val Lys Leu Gln Pro Ile Tyr Glu Glu Asn 
             1380                1385                1390
Leu Tyr Met Tyr Leu Tyr Phe Val Ile Phe Ile Ile Phe Gly Ser Phe 
         1395                1400                1405
Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp Asn Phe Asn Gln 
     1410                1415                1420
Gln Lys Lys Lys Phe Gly Gly Gln Asp Ile Phe Met Thr Glu Glu Gln 
 1425                1430                1435                1440
Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser Lys Lys Pro Gln 
                 1445                1450                1455
Lys Pro Ile Pro Arg Pro Ala Asn Lys Phe Gln Gly Met Val Phe Asp 
             1460                1465                1470
Phe Val Thr Arg Gln Val Phe Asp Ile Ser Ile Met Ile Leu Ile Cys 
         1475                1480                1485
Leu Asn Met Val Thr Met Met Val Glu Thr Asp Asp Gln Ser Lys Tyr 
     1490                1495                1500
Met Thr Leu Val Leu Ser Arg Ile Asn Leu Val Phe Ile Val Leu Phe 
 1505                1510                1515                1520
Thr Gly Glu Phe Leu Leu Lys Leu Ile Ser Leu Arg Tyr Tyr Tyr Phe 
                 1525                1530                1535
Thr Ile Gly Trp Asn Ile Phe Asp Phe Val Val Val Ile Leu Ser Ile 
             1540                1545                1550
Val Gly Met Phe Leu Ala Glu Leu Ile Glu Lys Tyr Phe Val Ser Pro 
         1555                1560                1565
Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly Arg Ile Leu Arg 
     1570                1575                1580
Leu Ile Lys Gly Ala Lys Gly Ile Arg Thr Leu Leu Phe Ala Leu Met 
 1585                1590                1595                1600
Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu Leu Phe Leu Val 
                 1605                1610                1615
Met Phe Ile Tyr Ala Ile Phe Gly Met Ser Asn Phe Ala Tyr Val Lys 
             1620                1625                1630
Lys Glu Ala Gly Ile Asp Asp Met Phe Asn Phe Glu Thr Phe Gly Asn 
         1635                1640                1645
Ser Met Ile Cys Leu Phe Gln Ile Thr Thr Ser Ala Gly Trp Asp Gly 
     1650                1655                1660
Leu Leu Ala Pro Ile Leu Asn Ser Ala Pro Pro Asp Cys Asp Pro Asp 
 1665                1670                1675                1680
Ala Ile His Pro Gly Ser Ser Val Lys Gly Asp Cys Gly Asn Pro Ser 
                 1685                1690                1695
Val Gly Ile Phe Phe Phe Val Ser Tyr Ile Ile Ile Ser Phe Leu Val 
             1700                1705                1710
Val Val Asn Met Tyr Ile Ala Val Ile Leu Glu Asn Phe Ser Val Ala 
         1715                1720                1725
Thr Glu Glu Ser Ala Glu Pro Leu Ser Glu Asp Asp Phe Glu Met Phe 
     1730                1735                1740
Tyr Glu Val Trp Glu Lys Phe Asp Pro Asp Ala Thr Gln Phe Ile Glu 
 1745                1750                1755                1760
Phe Cys Lys Leu Ser Asp Phe Ala Ala Ala Leu Asp Pro Pro Leu Leu 
                 1765                1770                1775
Ile Ala Lys Pro Asn Lys Val Gln Leu Ile Ala Met Asp Leu Pro Met 
             1780                1785                1790
Val Ser Gly Asp Arg Ile His Cys Leu Asp Ile Leu Phe Ala Phe Thr 
         1795                1800                1805
Lys Arg Val Leu Gly Glu Ser Gly Glu Met Asp Ala Leu Arg Ile Gln 
     1810                1815                1820
Met Glu Asp Arg Phe Met Ala Ser Asn Pro Ser Lys Val Ser Tyr Glu 
 1825                1830                1835                1840
Pro Ile Thr Thr Thr Leu Lys Arg Lys Gln Glu Glu Val Ser Ala Ala 
                 1845                1850                1855
Ile Ile Gln Arg Asn Tyr Arg Cys Tyr Leu Leu Lys Gln Arg Leu Lys 
             1860                1865                1870
Asn Ile Ser Ser Lys Tyr Asp Lys Glu Thr Ile Lys Gly Arg Ile Asp 
         1875                1880                1885
Leu Pro Ile Lys Gly Asp Met Val Ile Asp Lys Leu Asn Gly Asn Ser 
     1890                1895                1900
Thr Pro Glu Lys Thr Asp Gly Ser Ser Ser Thr Thr Ser Pro Pro Ser 
 1905                1910                1915                1920
Tyr Asp Ser Val Thr Lys Pro Asp Lys Glu Lys Phe Glu Lys Asp Lys 
                 1925                1930                1935
Pro Glu Lys Glu Ile Lys Gly Lys Glu Val Arg Glu Asn Gln Lys 
             1940                1945                1950



<210> 5525
<211> 7831
<212> DNA
<213> Homo sapiens
<308> XM_008249
<400> 5525

ccagcaccc  ggggctgcg  actgcagct  cccaggcca  ccaccaccc  tctggtctc  60
gagcccagg  tgcgaggat  gccagacca  ctctgtgca  cctggtgcc  ctgggccct  120
agtgcttgc  ccccttcac  cgggagtca  tggcagcca  agaacagcg  gcggtggag  180
aggaggccc  gctgcagcg  aataagcag  tggagattg  ggagcccga  cggaagcca  240
gaagtgact  ggaggctgg  aagaaccta  ccatgatct  cggagaccc  ccgccggag  300
tcatcggca  ccccctgga  gacctggat  cctactaca  caataagaa  accttcatc  360
tactcaaca  gggcaaggc  atcttccgc  tctccgcca  acctgctct  tacctgctg  420
gccccttca  cgtagtcag  cgcggggcc  tcaaggtgc  catccatgc  ctgttcagc  480
tgttcatca  gatcaccat  ttgaccaac  gcgtattca  gaccatgag  gacccgcct  540
cctggtcca  gaatgtgga  tacaccttc  cagggatct  cacctttga  tccctcatc  600
agatactgg  ccgaggctt  tgtgtcgac  acttcacat  cctccggga  ccctggaac  660
ggctggact  cagtgtcat  atgatggcg  acctgacag  gtttgtgga  ttgggcaac  720
tctcagccc  gaggacctt  cgggtgctg  gggccctca  aaccatcac  gtcatccca  780
ggctgaaga  gatcgtggg  gccctgatc  agtcggtga  aaagctgtc  gatgtgatg  840
tcctcactg  cttctgcct  agcgtcttt  cgctggtag  actgcagct  ttcatggga  900
acctgaggc  gaagtgtgt  cgctggccc  cgccgttca  cgacaccaa  accacgtgg  960
acagcaatg  cacgtggta  ggcaatgac  catggtatg  caatgagat  tggtacggc  1020
atgactcat  gtatgccaa  gacacgtgg  acagccatg  aagctgggc  accaacgat  1080
cctttgatt  ggacgccta  atcagtgat  aagggaact  ctacttcct  gagggctcc  1140
acgatgccc  gctctgtgg  aacagcagt  atgctgggc  ctgccctga  ggttatgag  1200
gcatcaaga  cgggcggaa  cccaactat  gctacacca  ctatgacac  ttcagctgg  1260
ccttcttgg  tctcttccg  ctcatgaca  aggactatt  ggagaacct  ttccagctg  1320
cccttcgag  agctggcaa  acctacatg  tcttcttcg  ggtcatcat  ttcctgggc  1380
ctttctacc  catcaatct  atcctggcc  tggtggcca  ggcatatgc  gagcagaat  1440
aggccaccc  ggccgagga  aaggagaaa  aggaggagt  tcagcagat  cttgagaag  1500
tcaaaaagc  ccaggagga  ctggagaag  ccaaggccg  ccaagctct  gaaggtggg  1560
aggcagatg  ggacccagc  catggcaaa  actgcaatg  cagcctgga  acatcgcaa  1620
gggagaagg  agccccgag  cagagcggc  gcggagaca  cggcatctc  gacgccatg  1680
aagaactgg  agaggccca  caaaagtgc  caccatggt  gtacaagtg  gcccacaaa  1740
tgctcatat  gaactgctg  gccccgtgg  tgaagttca  gaacatcat  cacctgatc  1800
tcatggacc  gttcgtgga  ctgggcatc  ccatctgca  cgtgctcaa  accctcttc  1860
tggccatgg  acattaccc  atgacggag  actttgaca  cgtgctcac  gtgggcaac  1920
tggtcttca  aggcatctt  acagcagag  tggttctga  gctgattgc  atggacccc  1980
acgagtatt  ccagcaggg  tggaatatc  tcgacagca  catcgtcac  ctcagcctg  2040
tagagctag  cctggccaa  gtacaggga  tgtctgtgc  acgctcctt  cgtctgctg  2100
gggtcttca  gctggccaa  tcgtggcca  cgctgaaca  gctcatcaa  atcattggc  2160
attcagtgg  ggcgctggg  aacctgacg  tggtgctgg  tatcatcgt  ttcatcttc  2220
ccgtggtgg  catgcagct  tttggcaag  gctacaagg  gtgcgtgtg  aagattgcc  2280
tggactgca  cctgccgcg  tggcacatg  atgatttct  ccactcctt  ctcatcgtc  2340
tccgcatcc  gtgcgggga  tggatcgag  ccatgtggg  ctgcatgga  gtggccggc  2400
aagccatgt  cctcaccgt  ttcctcatg  tcatggtca  cggcaatct  gtggtcctg  2460
acctgttcc  ggctctgct  ctgagctcc  tcagcgccg  cagtctggc  gcctcggat  2520
aggatggcg  gatgaacaa  ctgcagatt  ccatcgggc  catcaagtt  ggcatcggc  2580
ttgccaagg  cttcctcct  gggctgctg  atggcaaga  cctgagccc  aaggacatc  2640
tgctcagcc  cggggaggc  gacggggcc  gggaggctg  agaggcggg  gagactgcc  2700
ccgaggatg  gaagaagga  ccgcccgag  aggacctga  gaaggacaa  cacatcctg  2760
accacatgg  cctggctga  ggcccccca  ccagcctcg  gctggacca  cttaacttc  2820
tcaacaacc  ctacctgac  atacaggtg  ccatcgcct  cgaggagtc  gacctggag  2880
tgcccaccg  ggaggaaac  gacactttc  cagagcctg  ggatagcaa  aagccgccg  2940
agcctctct  tgatgggaa  tcgtccgtc  gcagcacag  tgactacaa  ccccccgag  3000
aggaccctg  ggagcaggc  gaggagaac  ccgaggggg  gcagcctga  gagtgcttc  3060
ctgaggcct  cgtgcagcg  tggccctgc  tctacgtgg  catctccca  ggccgtggg  3120
agaagtggt  gactctgcg  agggcctgc  tcaagattg  cgagcacaa  tggttcgag  3180
ccttcattg  cttcatgat  ctgctcagc  gtggggctc  ggccttcga  gacatctac  3240
ttgagcagc  gcgagtcat  cgcaccatc  tagaatatg  cgacaaggt  ttcacctac  3300
tcttcatca  ggagatgct  ctcaaatgg  tggcctacg  ctttaaggt  tacttcacc  3360
acgcctggt  ctggctcga  ttcctcatc  tggatgtct  catcatcag  ttggtggcc  3420
actggctgg  ctactcgga  ctgggaccc  tcaaatccc  gcggacact  cgggccctg  3480
gtcccctga  ggcactgtc  cgattcgag  gcatgaggg  ggtggtgaa  gccctccta  3540
gcgccatcc  ctccatcat  aatgtgctg  ttgtctgcc  catcttctg  ctgatcttc  3600
gcatcatgg  tgtcaacct  tttgccggc  agttctact  ctgcatcaa  accaccacc  3660
ctgagaggt  cgacatctc  gaggtcaac  acaagtctg  gtgcgagag  ctcatgcac  3720
caggccagg  ccgctggct  aatgtcaag  tcaactacg  caacgtggg  ctgggctac  3780
tctccctcc  gcaggtggc  accttcaag  gttggatgg  catcatgta  gcagccgtg  3840
actcccggg  gaaggagga  cagccgcag  acgaggtga  cctctacat  tacctctac  3900
ttgtcatct  catcatctt  ggctccttc  tcaccctca  cctcttcat  ggcgtcatc  3960
ttgacaact  caaccagca  aagaagaag  tagggggga  agacatctt  atgacggag  4020
aacagaaga  atactataa  gccatgaag  agcttggct  caagaagcc  cagaagcca  4080
ttccccggc  ccagaacaa  atccagggc  tggtgtatg  cctcgtgac  aagcaggcc  4140
tcgacatca  catcatgat  ctcatctgc  tcaacatgg  caccatgat  gtggagaca  4200
acaaccaga  ccagctcaa  gtggacatc  tgtacaaca  caacatgat  ttcatcatc  4260
tcttcacag  ggagtgcgt  ctcaagatg  tcgccctgc  ccagtacta  ttcaccgtt  4320
gctggaaca  ctttgactt  gtggtcgtc  tcctgtcca  tgtgggcct  gccctctct  4380
acctgatcc  gaagtactt  gtgtcaccc  cgctgttcc  tgtgatccg  ctggcgcgg  4440
ttgggcgtg  cctgcggct  atccgcggg  ccaagggca  ccggacgct  ctgttcgcc  4500
tcatgatgt  gctgcctgc  ctcttcaac  tcggcctcc  cctcttcct  gtcatgttc  4560
tctactcca  cttcggcat  tccaacttt  cctacgtca  gaaggagtc  ggcatcgat  4620
atatgttca  cttcgagac  ttcggcaac  gcatcatct  cctgttcga  atcaccacg  4680
cggccggct  ggacgggct  ctcaacccc  tcctcaaca  cgggccccc  gactgtgac  4740
ccaacctgg  gaacccggg  accagtgtc  agggtgact  cggcaaccc  tccatcggc  4800
tctgcttct  ctgcagcta  atcatcatc  ccttcctca  cgtggtcaa  atgtacatc  4860
ccatcatcc  ggagaactt  aatgtggcc  cagaggaga  cagcgagcc  cttggtgaa  4920
atgactttg  gatgttcta  gagacatgg  agaagttcg  ccccgacgc  acccagttc  4980
tcgcctaca  ccgcctctc  gacttcgtg  acaccctgc  ggaaccgct  aggattgcc  5040
agcccaaca  gatcaagct  atcacactg  acttgccca  ggtgccagg  gacaagatc  5100
actgcctgg  catcctctt  gccctgacc  aagaggtcc  gggtgactc  ggggaaatg  5160
acgccctca  gcagaccat  gaggagaag  tcatggcag  caacccctc  aaggtgtcc  5220
acgagccca  caccaccac  ctcaagagg  agcacgagg  ggtgtgcgc  atcaagatc  5280
agagggcct  ccgccggca  ctgctacag  gctccatga  gcaggcatc  tacatgtac  5340
gccacagcc  cgacggcag  ggggatgac  cccctgaga  ggaggggct  cttgccaac  5400
ccatgagca  gatgtatgg  cacgagaat  ggaacagca  ctcgccaag  ccggaggag  5460
agggcgagg  aggggacgc  ggacccact  tggggctga  gcccatcag  ccctcagac  5520
ctgcctggc  tcccgcccc  cccccaggg  agactgtgc  cccaggtgt  aaggagtct  5580
ttgtctagc  ggcagcatc  gggtggccc  ctgagtctc  gcatagtcc  cagagctcc  5640
ccgtggtgc  tgcacacag  gtgagggag  agggctttg  atctgggac  gtgcctggc  5700
ccctgatgg  ggacaggat  tggccacac  ggggctgac  cccaggccc  agcgcctgc  5760
ttcccagac  atgggaaat  ggaattgcg  tcaggggct  catgctggg  ctgaggccc  5820
tgcctccaa  atttaacct  caagttgct  tgacctcct  tgggccctg  cgcccctcc  5880
tttggcctg  gggaggtca  aacattcga  tctctgccc  tcacttgag  aggagctgg  5940
ctgcggtgg  gggatcagt  gccccccat  accagagtc  taagggtca  tggcctctc  6000
ccaggaagt  gctcagacc  ctcagcccc  gcccagaca  agatgtctt  acctcaggg  6060
gtgcagaca  ctaacccca  ggcactgcc  gcccacccc  tttgactct  gggtgcagc  6120
tcacccacc  ggccagctc  ggaattccc  agaaaaggg  aatgtgact  gttcagaaa  6180
agctcctca  agcctcaaa  cctgattgg  cactggatc  tgctgcttt  ggctgggat  6240
gtgactcct  aaacctctt  ctaggccac  tccaggtcc  tagctcccc  ggctggccc  6300
taggggaag  gcagaagga  ggatgccac  tgggaatga  ttgtccttt  ctaggaagc  6360
cgggggagt  agacaggct  ggtcctgcc  gctggatcg  tgcacatgg  ctgagcatc  6420
agacctgag  gggagtcag  gacctgctg  tcagtaaga  gattctcgc  ccttccctc  6480
ctccctgcc  cactcctcc  tgagcacca  cagggctcc  ggagcctca  ccagcctca  6540
agatctccc  tctcatctc  ccacgcccg  ctctttctc  cctttccca  ctctctccc  6600
aaagtgatc  taagaatgt  cagttgagc  caggttaga  atttcgacc  tggggcgtg  6660
agcagggaa  gcccaactg  ttcaggctc  accttccaa  ttcctgtgg  ctgaagaag  6720
acttctgct  catcgctgt  ctgggcatg  cagggccag  cctctgctg  ctcctggag  6780
gcagaggct  tgcccagag  aggaggggt  agagacctg  tcaggcgtc  ctggattta  6840
tcacttgtg  gtgtacctg  ggctgtgtg  ctgcttgta  gcatttata  gcctgtgtg  6900
atagctgtg  gtgtgttca  gtgcgtgac  gtatgtgtg  gtgtgaacc  ctgtgtact  6960
gagcctgca  tatgcacgt  tctgggtat  tttgtatat  tgtgtatat  tgtgtgccc  7020
ggactgttt  aaggtccac  gagtacggc  ggtgtgtca  actgtgcag  cctgtccct  7080
ggagtgttc  cgtgcctgg  agagtggac  tgtgctgtg  gtgtgtgga  gcgtgtgaa  7140
gcatgtggt  aggtgtgta  tcagggcat  ctgttggcc  aagtgcctc  tctttttct  7200
cttgtttct  atgaaaagt  tgattaaaa  tcaggaagc  gcaaaacct  caaaacaag  7260
catgtatgt  tgcttgagt  tgtgaacac  tgtgtgtgt  tgtgcacat  tacatgcca  7320
gcctatggg  cagagttgt  tttattgtc  accatgctc  ctcacctgc  cccagtcct  7380
cctgaacag  cctctctct  actcccctc  cctcccctt  ctgtttctc  ttgtcacac  7440
catggcctc  gccctgctc  ctgcctcct  cctatgtct  ctctatgga  ggaggcctc  7500
actccttcc  tctcttcct  cagaagttt  gtctaatgg  ggcagtctc  ccttcctgg  7560
acattgccc  tctgccttg  cctcctggg  cctgggctg  cacagcccc  ggagcctca  7620
aaatctgtt  gattggata  tctcctcgg  ctgtgtgca  gttgcagag  aagagtaga  7680
gagccgggt  cggcctctc  ctgcctgtg  cccctcccc  gcagacgga  gcccattcc  7740
gcctggtcc  gtggggaac  ggtcccacg  caggccagc  ggcgggctc  tttgtacag  7800
tcttacaat  aaccctcct  ggtgcctct  g  7831



<210> 5526
<211> 1836
<212> PRT
<213> Homo sapiens
<308> XP_008249
<400> 5526

Met Ala Arg Pro Ser Leu Cys Thr Leu Val Pro Leu Gly Pro Glu Cys 
  1               5                  10                  15
Leu Arg Pro Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ala 
             20                  25                  30
Val Glu Glu Glu Ala Arg Leu Gln Arg Asn Lys Gln Met Glu Ile Glu 
         35                  40                  45
Glu Pro Glu Arg Lys Pro Arg Ser Asp Leu Glu Ala Gly Lys Asn Leu 
     50                  55                  60
Pro Met Ile Tyr Gly Asp Pro Pro Pro Glu Val Ile Gly Ile Pro Leu 
 65                  70                  75                  80
Glu Asp Leu Asp Pro Tyr Tyr Ser Asn Lys Lys Thr Phe Ile Val Leu 
                 85                  90                  95
Asn Lys Gly Lys Ala Ile Phe Arg Phe Ser Ala Thr Pro Ala Leu Tyr 
             100                105                110
Leu Leu Ser Pro Phe Ser Val Val Arg Arg Gly Ala Ile Lys Val Leu 
         115                120                125
Ile His Ala Leu Phe Ser Met Phe Ile Met Ile Thr Ile Leu Thr Asn 
     130                135                140
Cys Val Phe Met Thr Met Ser Asp Pro Pro Pro Trp Ser Lys Asn Val 
 145                150                155                160
Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile 
                 165                170                175
Leu Ala Arg Gly Phe Cys Val Asp Asp Phe Thr Phe Leu Arg Asp Pro 
             180                185                190
Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Leu Thr Glu 
         195                200                205
Phe Val Asp Leu Gly Asn Ile Ser Ala Leu Arg Thr Phe Arg Val Leu 
     210                215                220
Arg Ala Leu Lys Thr Ile Thr Val Ile Pro Gly Leu Lys Thr Ile Val 
 225                230                235                240
Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu 
                 245                250                255
Thr Val Phe Cys Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe 
             260                265                270
Met Gly Asn Leu Arg Gln Lys Cys Val Arg Trp Pro Pro Pro Phe Asn 
         275                280                285
Asp Thr Asn Thr Thr Trp Tyr Ser Asn Asp Thr Trp Tyr Gly Asn Asp 
     290                295                300
Thr Trp Tyr Gly Asn Glu Met Trp Tyr Gly Asn Asp Ser Trp Tyr Ala 
 305                310                315                320
Asn Asp Thr Trp Asn Ser His Ala Ser Trp Ala Thr Asn Asp Thr Phe 
                 325                330                335
Asp Trp Asp Ala Tyr Ile Ser Asp Glu Gly Asn Phe Tyr Phe Leu Glu 
             340                345                350
Gly Ser Asn Asp Ala Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly His 
         355                360                365
Cys Pro Glu Gly Tyr Glu Cys Ile Lys Thr Gly Arg Asn Pro Asn Tyr 
     370                375                380
Gly Tyr Thr Ser Tyr Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe 
 385                390                395                400
Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Phe Gln Leu Thr Leu 
                 405                410                415
Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Ile Ile Phe 
             420                425                430
Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val Ala Met 
         435                440                445
Ala Tyr Ala Glu Gln Asn Glu Ala Thr Leu Ala Glu Asp Lys Glu Lys 
     450                455                460
Glu Glu Glu Phe Gln Gln Met Leu Glu Lys Phe Lys Lys His Gln Glu 
 465                470                475                480
Glu Leu Glu Lys Ala Lys Ala Ala Gln Ala Leu Glu Gly Gly Glu Ala 
                 485                490                495
Asp Gly Asp Pro Ala His Gly Lys Asp Cys Asn Gly Ser Leu Asp Thr 
             500                505                510
Ser Gln Gly Glu Lys Gly Ala Pro Arg Gln Ser Gly Ser Gly Asp Ser 
         515                520                525
Gly Ile Ser Asp Ala Met Glu Glu Leu Glu Glu Ala His Gln Lys Cys 
     530                535                540
Pro Pro Trp Trp Tyr Lys Cys Ala His Lys Val Leu Ile Trp Asn Cys 
 545                550                555                560
Cys Ala Pro Trp Leu Lys Phe Lys Asn Ile Ile His Leu Ile Val Met 
                 565                570                575
Asp Pro Phe Val Asp Leu Gly Ile Thr Ile Cys Ile Val Leu Asn Thr 
             580                585                590
Leu Phe Met Ala Met Glu His Tyr Pro Met Thr Glu His Phe Asp Asn 
         595                600                605
Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu 
     610                615                620
Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Gln 
 625                630                635                640
Gly Trp Asn Ile Phe Asp Ser Ile Ile Val Thr Leu Ser Leu Val Glu 
                 645                650                655
Leu Gly Leu Ala Asn Val Gln Gly Leu Ser Val Leu Arg Ser Phe Arg 
             660                665                670
Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met 
         675                680                685
Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr 
     690                695                700
Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln 
 705                710                715                720
Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Ala Leu Asp 
                 725                730                735
Cys Asn Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu 
             740                745                750
Ile Val Phe Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp 
         755                760                765
Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Leu Met 
     770                775                780
Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu 
 785                790                795                800
Leu Leu Ser Ser Phe Ser Ala Asp Ser Leu Ala Ala Ser Asp Glu Asp 
                 805                810                815
Gly Glu Met Asn Asn Leu Gln Ile Ala Ile Gly Arg Ile Lys Leu Gly 
             820                825                830
Ile Gly Phe Ala Lys Ala Phe Leu Leu Gly Leu Leu His Gly Lys Ile 
         835                840                845
Leu Ser Pro Lys Asp Ile Met Leu Ser Leu Gly Glu Ala Asp Gly Ala 
     850                855                860
Gly Glu Ala Gly Glu Ala Gly Glu Thr Ala Pro Glu Asp Glu Lys Lys 
 865                870                875                880
Glu Pro Pro Glu Glu Asp Leu Lys Lys Asp Asn His Ile Leu Asn His 
                 885                890                895
Met Gly Leu Ala Asp Gly Pro Pro Ser Ser Leu Glu Leu Asp His Leu 
             900                905                910
Asn Phe Ile Asn Asn Pro Tyr Leu Thr Ile Gln Val Pro Ile Ala Ser 
         915                920                925
Glu Glu Ser Asp Leu Glu Met Pro Thr Glu Glu Glu Thr Asp Thr Phe 
     930                935                940
Ser Glu Pro Glu Asp Ser Lys Lys Pro Pro Gln Pro Leu Tyr Asp Gly 
 945                950                955                960
Asn Ser Ser Val Cys Ser Thr Ala Asp Tyr Lys Pro Pro Glu Glu Asp 
                 965                970                975
Pro Glu Glu Gln Ala Glu Glu Asn Pro Glu Gly Glu Gln Pro Glu Glu 
             980                985                990
Cys Phe Thr Glu Ala Cys Val Gln Arg Trp Pro Cys Leu Tyr Val Asp 
         995                1000                1005
Ile Ser Gln Gly Arg Gly Lys Lys Trp Trp Thr Leu Arg Arg Ala Cys 
     1010                1015                1020
Phe Lys Ile Val Glu His Asn Trp Phe Glu Thr Phe Ile Val Phe Met 
 1025                1030                1035                1040
Ile Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu 
                 1045                1050                1055
Gln Arg Arg Val Ile Arg Thr Ile Leu Glu Tyr Ala Asp Lys Val Phe 
             1060                1065                1070
Thr Tyr Ile Phe Ile Met Glu Met Leu Leu Lys Trp Val Ala Tyr Gly 
         1075                1080                1085
Phe Lys Val Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile 
     1090                1095                1100
Val Asp Val Ser Ile Ile Ser Leu Val Ala Asn Trp Leu Gly Tyr Ser 
 1105                1110                1115                1120
Glu Leu Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro 
                 1125                1130                1135
Leu Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala 
             1140                1145                1150
Leu Leu Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu 
         1155                1160                1165
Ile Phe Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly 
     1170                1175                1180
Lys Phe Tyr Tyr Cys Ile Asn Thr Thr Thr Ser Glu Arg Phe Asp Ile 
 1185                1190                1195                1200
Ser Glu Val Asn Asn Lys Ser Glu Cys Glu Ser Leu Met His Thr Gly 
                 1205                1210                1215
Gln Val Arg Trp Leu Asn Val Lys Val Asn Tyr Asp Asn Val Gly Leu 
             1220                1225                1230
Gly Tyr Leu Ser Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp 
         1235                1240                1245
Ile Met Tyr Ala Ala Val Asp Ser Arg Glu Lys Glu Glu Gln Pro Gln 
     1250                1255                1260
Tyr Glu Val Asn Leu Tyr Met Tyr Leu Tyr Phe Val Ile Phe Ile Ile 
 1265                1270                1275                1280
Phe Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp 
                 1285                1290                1295
Asn Phe Asn Gln Gln Lys Lys Lys Leu Gly Gly Lys Asp Ile Phe Met 
             1300                1305                1310
Thr Glu Glu Gln Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser 
         1315                1320                1325
Lys Lys Pro Gln Lys Pro Ile Pro Arg Pro Gln Asn Lys Ile Gln Gly 
     1330                1335                1340
Met Val Tyr Asp Leu Val Thr Lys Gln Ala Phe Asp Ile Thr Ile Met 
 1345                1350                1355                1360
Ile Leu Ile Cys Leu Asn Met Val Thr Met Met Val Glu Thr Asp Asn 
                 1365                1370                1375
Gln Ser Gln Leu Lys Val Asp Ile Leu Tyr Asn Ile Asn Met Ile Phe 
             1380                1385                1390
Ile Ile Ile Phe Thr Gly Glu Cys Val Leu Lys Met Leu Ala Leu Arg 
         1395                1400                1405
Gln Tyr Tyr Phe Thr Val Gly Trp Asn Ile Phe Asp Phe Val Val Val 
     1410                1415                1420
Ile Leu Ser Ile Val Gly Leu Ala Leu Ser Asp Leu Ile Gln Lys Tyr 
 1425                1430                1435                1440
Phe Val Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly 
                 1445                1450                1455
Arg Val Leu Arg Leu Ile Arg Gly Ala Lys Gly Ile Arg Thr Leu Leu 
             1460                1465                1470
Phe Ala Leu Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu 
         1475                1480                1485
Leu Phe Leu Val Met Phe Ile Tyr Ser Ile Phe Gly Met Ser Asn Phe 
     1490                1495                1500
Ala Tyr Val Lys Lys Glu Ser Gly Ile Asp Asp Met Phe Asn Phe Glu 
 1505                1510                1515                1520
Thr Phe Gly Asn Ser Ile Ile Cys Leu Phe Glu Ile Thr Thr Ser Ala 
                 1525                1530                1535
Gly Trp Asp Gly Leu Leu Asn Pro Ile Leu Asn Ser Gly Pro Pro Asp 
             1540                1545                1550
Cys Asp Pro Asn Leu Glu Asn Pro Gly Thr Ser Val Lys Gly Asp Cys 
         1555                1560                1565
Gly Asn Pro Ser Ile Gly Ile Cys Phe Phe Cys Ser Tyr Ile Ile Ile 
     1570                1575                1580
Ser Phe Leu Ile Val Val Asn Met Tyr Ile Ala Ile Ile Leu Glu Asn 
 1585                1590                1595                1600
Phe Asn Val Ala Thr Glu Glu Ser Ser Glu Pro Leu Gly Glu Asp Asp 
                 1605                1610                1615
Phe Glu Met Phe Tyr Glu Thr Trp Glu Lys Phe Asp Pro Asp Ala Thr 
             1620                1625                1630
Gln Phe Ile Ala Tyr Ser Arg Leu Ser Asp Phe Val Asp Thr Leu Gln 
         1635                1640                1645
Glu Pro Leu Arg Ile Ala Lys Pro Asn Lys Ile Lys Leu Ile Thr Leu 
     1650                1655                1660
Asp Leu Pro Met Val Pro Gly Asp Lys Ile His Cys Leu Asp Ile Leu 
 1665                1670                1675                1680
Phe Ala Leu Thr Lys Glu Val Leu Gly Asp Ser Gly Glu Met Asp Ala 
                 1685                1690                1695
Leu Lys Gln Thr Met Glu Glu Lys Phe Met Ala Ala Asn Pro Ser Lys 
             1700                1705                1710
Val Ser Tyr Glu Pro Ile Thr Thr Thr Leu Lys Arg Lys His Glu Glu 
         1715                1720                1725
Val Cys Ala Ile Lys Ile Gln Arg Ala Tyr Arg Arg His Leu Leu Gln 
     1730                1735                1740
Arg Ser Met Lys Gln Ala Ser Tyr Met Tyr Arg His Ser His Asp Gly 
 1745                1750                1755                1760
Ser Gly Asp Asp Ala Pro Glu Lys Glu Gly Leu Leu Ala Asn Thr Met 
                 1765                1770                1775
Ser Lys Met Tyr Gly His Glu Asn Gly Asn Ser Ser Ser Pro Ser Pro 
             1780                1785                1790
Glu Glu Lys Gly Glu Ala Gly Asp Ala Gly Pro Thr Met Gly Leu Met 
         1795                1800                1805
Pro Ile Ser Pro Ser Asp Thr Ala Trp Pro Pro Ala Pro Pro Pro Gly 
     1810                1815                1820
Gln Thr Val Arg Pro Gly Val Lys Glu Ser Leu Val 
 1825                1830                1835



<210> 5527
<211> 591
<212> DNA
<213> Rattus norvegicus
<308> AA891760
<400> 5527

catgacaga  aaggttgct  tttattggt  aaagtcccg  ctggcccgc  gactcaaca  60
tgcacacct  ataggggtt  agccaggga  gctcgtccc  actgggcag  caccaaggg  120
gatgacagg  gctgtggcc  ggtcaccac  caggagcag  tgagccttt  gtttgtttg  180
tccctaagg  cctaccagg  cctacccac  gtacttcca  caagcatcc  tcaggccct  240
actaacccc  caagtcatc  tagcagagt  aagacacag  aaacagcac  cagctaaaa  300
aaaccaatg  gccgtgggg  gtgggggat  tctcagccc  tcacagaca  ctgtaccta  360
ctccctaga  tcagacacc  caggggtgg  aggtgcatg  gacaggggg  gggtagtgg  420
tcgcaaagc  gatggtgag  ccatgaacg  gcaggtggc  caaggtgat  ctaggccag  480
tcctggcat  gagggccaa  gctcccaag  atcctgact  ggtaaggca  agagtttgg  540
ttttctcag  ggcccagtc  cagcctggc  ccgaagagc  tctgcaagc  g  591



<210> 5528
<211> 591
<212> DNA
<213> Rattus norvegicus
<308> AA891760
<400> 5528

catgacaga  aaggttgct  tttattggt  aaagtcccg  ctggcccgc  gactcaaca  60
tgcacacct  ataggggtt  agccaggga  gctcgtccc  actgggcag  caccaaggg  120
gatgacagg  gctgtggcc  ggtcaccac  caggagcag  tgagccttt  gtttgtttg  180
tccctaagg  cctaccagg  cctacccac  gtacttcca  caagcatcc  tcaggccct  240
actaacccc  caagtcatc  tagcagagt  aagacacag  aaacagcac  cagctaaaa  300
aaaccaatg  gccgtgggg  gtgggggat  tctcagccc  tcacagaca  ctgtaccta  360
ctccctaga  tcagacacc  caggggtgg  aggtgcatg  gacaggggg  gggtagtgg  420
tcgcaaagc  gatggtgag  ccatgaacg  gcaggtggc  caaggtgat  ctaggccag  480
tcctggcat  gagggccaa  gctcccaag  atcctgact  ggtaaggca  agagtttgg  540
ttttctcag  ggcccagtc  cagcctggc  ccgaagagc  tctgcaagc  g  591



<210> 5529
<211> 555
<212> DNA
<213> Rattus norvegicus
<308> AA891774
<400> 5529

ccagggacc  ccgtagtcg  tctccctat  ccactccca  acctcagag  aggaaatgg  60
cttggctga  aagattcat  cttgatgac  aggggaggc  tgcagcccc  caagaagaa  120
gggaaaaga  aaacgggga  gttgaaaag  agagaggtg  accttccct  ctgaggaag  180
aattctggt  tgggaccag  tgcaagggg  tagtaagag  aacctaagg  gtgcttaca  240
ttttattct  gcaaatgaa  ctcttaaaa  gctccctcc  aggggtgct  acattttta  300
tctggcaaa  gaatctctt  aaaggctcc  tccttcgtt  gggggaaca  cacatgtac  360
tgtgtcagc  tgagatgca  tgctacaca  gaacgtggc  ttgggccaa  catgtggac  420
cctgtgctg  tcccaaggg  gaggttctg  ttgggtgtg  gataaatct  aacaagcat  480
cactcgtgt  atatgtggc  ttaagggta  gggagcaaa  ggaatggac  tctctgtag  540
gcagctcaa  aggga  555



<210> 5530
<211> 518
<212> DNA
<213> Rattus norvegicus
<308> AA891785
<400> 5530

gaagagctt  ttagtagct  aatatggca  cacgtgact  agggcaata  aaattacag  60
atgcaaaac  cactgactg  ctgaggtaa  gcgcaccgt  cctgcctcg  gtccactgt  120
agggaaatt  ctcacatgc  ttaaaaaac  tctccatca  atatatata  atgtaaaaa  180
ataatcccc  agaaaggcc  ccagagagg  gggctacaa  gcccaccct  taccatgta  240
ggagcaccc  ctggagctg  gtagtgtag  gtccacccc  actgcttgc  cagagctct  300
tgtccaggc  aagatgctg  caatagggt  ggtactggt  ggccggccc  tctggtgtt  360
tcggtagtg  cgggtgact  tcccgtgag  agcctcagc  tcaatggtc  tcccgtcag  420
gcagaccag  acagatgtc  tcaggccaa  ggagccaaa  ccttgagcc  ggatgtcag  480
ctgtacatc  ccgtcatag  tcttgcagg  ccacacaa  518



<210> 5531
<211> 452
<212> PRT
<213> Rattus norvegicus
<308> AAG43538
<400> 5531

Met Ala Gly Tyr Leu Arg Ala Val Ser Ser Leu Cys Arg Ala Ser Gly 
  1               5                  10                  15
Ser Ala Arg Thr Trp Ala Pro Ala Ala Leu Thr Val Pro Ser Trp Pro 
             20                  25                  30
Glu Gln Pro Arg Arg His Tyr Ala Glu Lys Arg Ile Lys Val Glu Lys 
         35                  40                  45
Pro Val Val Glu Met Asp Gly Asp Glu Met Thr Arg Ile Ile Trp Gln 
     50                  55                  60
Phe Ile Lys Glu Lys Leu Ile Leu Pro His Val Asp Val Gln Leu Lys 
 65                  70                  75                  80
Tyr Phe Asp Leu Gly Leu Pro Asn Arg Asp Gln Thr Asn Asp Gln Val 
                 85                  90                  95
Thr Ile Asp Ser Ala Leu Ala Thr Gln Lys Tyr Ser Val Ala Val Lys 
             100                105                110
Cys Ala Thr Ile Thr Pro Asp Glu Ala Arg Val Glu Glu Phe Lys Leu 
         115                120                125
Lys Lys Met Trp Lys Ser Pro Asn Gly Thr Ile Arg Asn Ile Leu Gly 
     130                135                140
Gly Thr Val Phe Arg Glu Pro Ile Ile Cys Lys Asn Ile Pro Arg Leu 
 145                150                155                160
Val Pro Gly Trp Thr Lys Pro Ile Thr Ile Gly Arg His Ala His Gly 
                 165                170                175
Asp Gln Tyr Lys Ala Thr Asp Phe Val Val Asp Arg Ala Gly Thr Phe 
             180                185                190
Lys Leu Val Phe Thr Pro Lys Asp Gly Ser Ser Ala Lys Glu Trp Glu 
         195                200                205
Val Tyr Asn Phe Pro Ala Gly Gly Val Gly Met Gly Met Tyr Asn Thr 
     210                215                220
Asp Glu Ser Ile Ser Gly Phe Ala His Ser Cys Phe Gln Tyr Ser Ile 
 225                230                235                240
Gln Lys Lys Trp Pro Leu Tyr Leu Ser Thr Lys Asn Thr Ile Leu Lys 
                 245                250                255
Ala Tyr Asp Gly Arg Phe Lys Asp Ile Phe Gln Glu Ile Phe Asp Lys 
             260                265                270
His Tyr Lys Thr Asp Phe Asp Arg Asn Lys Ile Trp Tyr Glu His Arg 
         275                280                285
Leu Ile Asp Asp Met Val Ala Gln Val Leu Lys Ser Ser Gly Gly Phe 
     290                295                300
Val Trp Ala Cys Lys Asn Tyr Asp Gly Asp Val Gln Ser Asp Ile Leu 
 305                310                315                320
Ala Gln Gly Phe Gly Ser Leu Gly Leu Met Thr Ser Val Leu Val Cys 
                 325                330                335
Pro Asp Gly Lys Thr Ile Glu Ala Glu Ala Ala His Gly Thr Val Thr 
             340                345                350
Arg His Tyr Arg Glu His Gln Lys Gly Arg Pro Thr Ser Thr Asn Pro 
         355                360                365
Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Glu His Arg Gly Lys 
     370                375                380
Leu Asp Gly Asn Gln Asp Leu Ile Arg Phe Ala Gln Thr Leu Glu Lys 
 385                390                395                400
Val Cys Val Gln Thr Val Glu Ser Gly Ala Met Thr Lys Asp Leu Ala 
                 405                410                415
Gly Cys Ile His Gly Leu Ser Asn Val Lys Leu Asn Glu His Phe Leu 
             420                425                430
Asn Thr Thr Asp Phe Leu Asp Thr Ile Lys Ser Asn Leu Asp Arg Ala 
         435                440                445
Leu Gly Lys Gln 
     450



<210> 5532
<211> 1596
<212> DNA
<213> Homo sapiens
<308> U52144
<400> 5532

gggaatgag  aaataactt  atttcattg  ggggagcgg  ccgatgtcc  gcctcagaa  60
ttctggaac  gcttcttgg  ccggcagcc  tggtgacct  gagcacgtt  aagcgcact  120
tcttgctca  aggccggca  tcgcccact  tgacgatgt  accgatctg  acgtccagc  180
aaagtattt  gacctcggg  tcccaaacc  tgaccagac  gatgaccag  tcaccattg  240
ctctgcact  gccacccag  agtacagtg  ggctgtcaa  tgtgccacc  tcacccctg  300
tgaggcccg  gtggaagag  tcaagctga  gaagatgtg  aaaagtccc  atggaacta  360
ccggaacat  catgggggg  ctgtcttcc  ggagcccat  atctgcaaa  acatcccac  420
cctagtccc  ggctggacc  agcccatca  cattggcag  cacgcccat  gcgaccagt  480
caaggccac  gactttgtg  cagaccggg  cggcacttt  aaaatggtc  tcaccccaa  540
agatggcag  ggtgtcaag  agtgggaag  gtacaactt  cccgcaggc  gcgtgggca  600
gggcatgta  aacaccgac  agtccatct  aggttttgc  cacagctgc  tccagtatg  660
catccagaa  aaatggccg  tgtacatga  caccaagaa  accatactg  aagcctacg  720
tgggcgttt  aaggacatc  tccaggaga  ctttgacaa  cactataag  ccgacttcg  780
caagaataa  atctggtat  agcaccggc  cattgatga  atggtggct  aggtcctca  840
gtcttcggg  ggctttgtg  gggcctgca  gaactatga  ggagatgtg  agtcagaca  900
cctggccca  ggctttggc  cccttggcc  gatgacgtc  gtcctggtc  gccctgatg  960
gaagacgat  gaggctgag  ccgctcatg  gaccgtcac  cgccactat  gggagcacc  1020
gaagggccg  cccaccagc  ccaacccca  cgccagcat  tttgcctgg  cacgtggcc  1080
ggagcaccg  gggaagctg  atgggaacc  agacctcat  aggtttgcc  agatgctgg  1140
gaaggtgtg  gtggagacg  tggagagtg  agccatgac  aaggacctg  cgggctgca  1200
tcacggcct  agcaatgtg  agctgaacg  gcacttcct  aacaccacg  acttcctcg  1260
caccatcaa  agcaacctg  acagagccc  gggcaggca  tagggggag  cgccaccca  1320
ggctgcagt  gaggggcca  ggctgagcc  gcgggtcct  ctgagcgcg  cagagggtg  1380
gcctcacag  ccctctctg  aggcctttc  aggggatgt  tttttataa  ccagatgtt  1440
ttaaaagca  atgtgtgtt  cccctcatg  tgacgtgag  caggagcag  gcgttttac  1500
tcagccagt  agtatgttt  gcatactgt  atttatatt  cccttggaa  acatggtgc  1560
atatttagc  actaaaaag  tcttcgcaa  aaaaaa  1596



<210> 5533
<211> 452
<212> PRT
<213> Homo sapiens
<308> P48735
<400> 5533

Met Ala Gly Tyr Leu Arg Val Val Arg Ser Leu Cys Arg Ala Ser Gly 
  1               5                  10                  15
Ser Arg Pro Ala Trp Ala Pro Ala Ala Leu Thr Ala Pro Thr Ser Gln 
             20                  25                  30
Glu Gln Pro Arg Arg His Tyr Ala Asp Lys Arg Ile Lys Val Ala Lys 
         35                  40                  45
Pro Val Val Glu Met Asp Gly Asp Glu Met Thr Arg Ile Ile Trp Gln 
     50                  55                  60
Phe Ile Lys Glu Lys Leu Ile Leu Pro His Val Asp Ile Gln Leu Lys 
 65                  70                  75                  80
Tyr Phe Asp Leu Gly Leu Pro Asn Arg Asp Gln Thr Asp Asp Gln Val 
                 85                  90                  95
Thr Ile Asp Ser Ala Leu Ala Thr Gln Lys Tyr Ser Val Ala Val Lys 
             100                105                110
Cys Ala Thr Ile Thr Pro Asp Glu Ala Arg Val Glu Glu Phe Lys Leu 
         115                120                125
Lys Lys Met Trp Lys Ser Pro Asn Gly Thr Ile Arg Asn Ile Leu Gly 
     130                135                140
Gly Thr Val Phe Arg Glu Pro Ile Ile Cys Lys Asn Ile Pro Arg Leu 
 145                150                155                160
Val Pro Gly Trp Thr Lys Pro Ile Thr Ile Gly Arg His Ala His Gly 
                 165                170                175
Asp Gln Tyr Lys Ala Thr Asp Phe Val Ala Asp Arg Ala Gly Thr Phe 
             180                185                190
Lys Met Val Phe Thr Pro Lys Asp Gly Ser Gly Val Lys Glu Trp Glu 
         195                200                205
Val Tyr Asn Phe Pro Ala Gly Gly Val Gly Met Gly Met Tyr Asn Thr 
     210                215                220
Asp Glu Ser Ile Ser Gly Phe Ala His Ser Cys Phe Gln Tyr Ala Ile 
 225                230                235                240
Gln Lys Lys Trp Pro Leu Tyr Met Ser Thr Lys Asn Thr Ile Leu Lys 
                 245                250                255
Ala Tyr Asp Gly Arg Phe Lys Asp Ile Phe Gln Glu Ile Phe Asp Lys 
             260                265                270
His Tyr Lys Thr Asp Phe Asp Lys Asn Lys Ile Trp Tyr Glu His Arg 
         275                280                285
Leu Ile Asp Asp Met Val Ala Gln Val Leu Lys Ser Ser Gly Gly Phe 
     290                295                300
Val Trp Ala Cys Lys Asn Tyr Asp Gly Asp Val Gln Ser Asp Ile Leu 
 305                310                315                320
Ala Gln Gly Phe Gly Ser Leu Gly Leu Met Thr Ser Val Leu Val Cys 
                 325                330                335
Pro Asp Gly Lys Thr Ile Glu Ala Glu Ala Ala His Gly Thr Val Thr 
             340                345                350
Arg His Tyr Arg Glu His Gln Lys Gly Arg Pro Thr Ser Thr Asn Pro 
         355                360                365
Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Glu His Arg Gly Lys 
     370                375                380
Leu Asp Gly Asn Gln Asp Leu Ile Arg Phe Ala Gln Met Leu Glu Lys 
 385                390                395                400
Val Cys Val Glu Thr Val Glu Ser Gly Ala Met Thr Lys Asp Leu Ala 
                 405                410                415
Gly Cys Ile His Gly Leu Ser Asn Val Lys Leu Asn Glu His Phe Leu 
             420                425                430
Asn Thr Thr Asp Phe Leu Asp Thr Ile Lys Ser Asn Leu Asp Arg Ala 
         435                440                445
Leu Gly Arg Gln 
     450



<210> 5534
<211> 518
<212> DNA
<213> Rattus norvegicus
<308> AA891785
<400> 5534

gaagagctt  ttagtagct  aatatggca  cacgtgact  agggcaata  aaattacag  60
atgcaaaac  cactgactg  ctgaggtaa  gcgcaccgt  cctgcctcg  gtccactgt  120
agggaaatt  ctcacatgc  ttaaaaaac  tctccatca  atatatata  atgtaaaaa  180
ataatcccc  agaaaggcc  ccagagagg  gggctacaa  gcccaccct  taccatgta  240
ggagcaccc  ctggagctg  gtagtgtag  gtccacccc  actgcttgc  cagagctct  300
tgtccaggc  aagatgctg  caatagggt  ggtactggt  ggccggccc  tctggtgtt  360
tcggtagtg  cgggtgact  tcccgtgag  agcctcagc  tcaatggtc  tcccgtcag  420
gcagaccag  acagatgtc  tcaggccaa  ggagccaaa  ccttgagcc  ggatgtcag  480
ctgtacatc  ccgtcatag  tcttgcagg  ccacacaa  518



<210> 5535
<211> 452
<212> PRT
<213> Rattus norvegicus
<308> AAG43538
<400> 5535

Met Ala Gly Tyr Leu Arg Ala Val Ser Ser Leu Cys Arg Ala Ser Gly 
  1               5                  10                  15
Ser Ala Arg Thr Trp Ala Pro Ala Ala Leu Thr Val Pro Ser Trp Pro 
             20                  25                  30
Glu Gln Pro Arg Arg His Tyr Ala Glu Lys Arg Ile Lys Val Glu Lys 
         35                  40                  45
Pro Val Val Glu Met Asp Gly Asp Glu Met Thr Arg Ile Ile Trp Gln 
     50                  55                  60
Phe Ile Lys Glu Lys Leu Ile Leu Pro His Val Asp Val Gln Leu Lys 
 65                  70                  75                  80
Tyr Phe Asp Leu Gly Leu Pro Asn Arg Asp Gln Thr Asn Asp Gln Val 
                 85                  90                  95
Thr Ile Asp Ser Ala Leu Ala Thr Gln Lys Tyr Ser Val Ala Val Lys 
             100                105                110
Cys Ala Thr Ile Thr Pro Asp Glu Ala Arg Val Glu Glu Phe Lys Leu 
         115                120                125
Lys Lys Met Trp Lys Ser Pro Asn Gly Thr Ile Arg Asn Ile Leu Gly 
     130                135                140
Gly Thr Val Phe Arg Glu Pro Ile Ile Cys Lys Asn Ile Pro Arg Leu 
 145                150                155                160
Val Pro Gly Trp Thr Lys Pro Ile Thr Ile Gly Arg His Ala His Gly 
                 165                170                175
Asp Gln Tyr Lys Ala Thr Asp Phe Val Val Asp Arg Ala Gly Thr Phe 
             180                185                190
Lys Leu Val Phe Thr Pro Lys Asp Gly Ser Ser Ala Lys Glu Trp Glu 
         195                200                205
Val Tyr Asn Phe Pro Ala Gly Gly Val Gly Met Gly Met Tyr Asn Thr 
     210                215                220
Asp Glu Ser Ile Ser Gly Phe Ala His Ser Cys Phe Gln Tyr Ser Ile 
 225                230                235                240
Gln Lys Lys Trp Pro Leu Tyr Leu Ser Thr Lys Asn Thr Ile Leu Lys 
                 245                250                255
Ala Tyr Asp Gly Arg Phe Lys Asp Ile Phe Gln Glu Ile Phe Asp Lys 
             260                265                270
His Tyr Lys Thr Asp Phe Asp Arg Asn Lys Ile Trp Tyr Glu His Arg 
         275                280                285
Leu Ile Asp Asp Met Val Ala Gln Val Leu Lys Ser Ser Gly Gly Phe 
     290                295                300
Val Trp Ala Cys Lys Asn Tyr Asp Gly Asp Val Gln Ser Asp Ile Leu 
 305                310                315                320
Ala Gln Gly Phe Gly Ser Leu Gly Leu Met Thr Ser Val Leu Val Cys 
                 325                330                335
Pro Asp Gly Lys Thr Ile Glu Ala Glu Ala Ala His Gly Thr Val Thr 
             340                345                350
Arg His Tyr Arg Glu His Gln Lys Gly Arg Pro Thr Ser Thr Asn Pro 
         355                360                365
Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Glu His Arg Gly Lys 
     370                375                380
Leu Asp Gly Asn Gln Asp Leu Ile Arg Phe Ala Gln Thr Leu Glu Lys 
 385                390                395                400
Val Cys Val Gln Thr Val Glu Ser Gly Ala Met Thr Lys Asp Leu Ala 
                 405                410                415
Gly Cys Ile His Gly Leu Ser Asn Val Lys Leu Asn Glu His Phe Leu 
             420                425                430
Asn Thr Thr Asp Phe Leu Asp Thr Ile Lys Ser Asn Leu Asp Arg Ala 
         435                440                445
Leu Gly Lys Gln 
     450



<210> 5536
<211> 1596
<212> DNA
<213> Homo sapiens
<308> U52144
<400> 5536

gggaatgag  aaataactt  atttcattg  ggggagcgg  ccgatgtcc  gcctcagaa  60
ttctggaac  gcttcttgg  ccggcagcc  tggtgacct  gagcacgtt  aagcgcact  120
tcttgctca  aggccggca  tcgcccact  tgacgatgt  accgatctg  acgtccagc  180
aaagtattt  gacctcggg  tcccaaacc  tgaccagac  gatgaccag  tcaccattg  240
ctctgcact  gccacccag  agtacagtg  ggctgtcaa  tgtgccacc  tcacccctg  300
tgaggcccg  gtggaagag  tcaagctga  gaagatgtg  aaaagtccc  atggaacta  360
ccggaacat  catgggggg  ctgtcttcc  ggagcccat  atctgcaaa  acatcccac  420
cctagtccc  ggctggacc  agcccatca  cattggcag  cacgcccat  gcgaccagt  480
caaggccac  gactttgtg  cagaccggg  cggcacttt  aaaatggtc  tcaccccaa  540
agatggcag  ggtgtcaag  agtgggaag  gtacaactt  cccgcaggc  gcgtgggca  600
gggcatgta  aacaccgac  agtccatct  aggttttgc  cacagctgc  tccagtatg  660
catccagaa  aaatggccg  tgtacatga  caccaagaa  accatactg  aagcctacg  720
tgggcgttt  aaggacatc  tccaggaga  ctttgacaa  cactataag  ccgacttcg  780
caagaataa  atctggtat  agcaccggc  cattgatga  atggtggct  aggtcctca  840
gtcttcggg  ggctttgtg  gggcctgca  gaactatga  ggagatgtg  agtcagaca  900
cctggccca  ggctttggc  cccttggcc  gatgacgtc  gtcctggtc  gccctgatg  960
gaagacgat  gaggctgag  ccgctcatg  gaccgtcac  cgccactat  gggagcacc  1020
gaagggccg  cccaccagc  ccaacccca  cgccagcat  tttgcctgg  cacgtggcc  1080
ggagcaccg  gggaagctg  atgggaacc  agacctcat  aggtttgcc  agatgctgg  1140
gaaggtgtg  gtggagacg  tggagagtg  agccatgac  aaggacctg  cgggctgca  1200
tcacggcct  agcaatgtg  agctgaacg  gcacttcct  aacaccacg  acttcctcg  1260
caccatcaa  agcaacctg  acagagccc  gggcaggca  tagggggag  cgccaccca  1320
ggctgcagt  gaggggcca  ggctgagcc  gcgggtcct  ctgagcgcg  cagagggtg  1380
gcctcacag  ccctctctg  aggcctttc  aggggatgt  tttttataa  ccagatgtt  1440
ttaaaagca  atgtgtgtt  cccctcatg  tgacgtgag  caggagcag  gcgttttac  1500
tcagccagt  agtatgttt  gcatactgt  atttatatt  cccttggaa  acatggtgc  1560
atatttagc  actaaaaag  tcttcgcaa  aaaaaa  1596



<210> 5537
<211> 452
<212> PRT
<213> Homo sapiens
<308> P48735
<400> 5537

Met Ala Gly Tyr Leu Arg Val Val Arg Ser Leu Cys Arg Ala Ser Gly 
  1               5                  10                  15
Ser Arg Pro Ala Trp Ala Pro Ala Ala Leu Thr Ala Pro Thr Ser Gln 
             20                  25                  30
Glu Gln Pro Arg Arg His Tyr Ala Asp Lys Arg Ile Lys Val Ala Lys 
         35                  40                  45
Pro Val Val Glu Met Asp Gly Asp Glu Met Thr Arg Ile Ile Trp Gln 
     50                  55                  60
Phe Ile Lys Glu Lys Leu Ile Leu Pro His Val Asp Ile Gln Leu Lys 
 65                  70                  75                  80
Tyr Phe Asp Leu Gly Leu Pro Asn Arg Asp Gln Thr Asp Asp Gln Val 
                 85                  90                  95
Thr Ile Asp Ser Ala Leu Ala Thr Gln Lys Tyr Ser Val Ala Val Lys 
             100                105                110
Cys Ala Thr Ile Thr Pro Asp Glu Ala Arg Val Glu Glu Phe Lys Leu 
         115                120                125
Lys Lys Met Trp Lys Ser Pro Asn Gly Thr Ile Arg Asn Ile Leu Gly 
     130                135                140
Gly Thr Val Phe Arg Glu Pro Ile Ile Cys Lys Asn Ile Pro Arg Leu 
 145                150                155                160
Val Pro Gly Trp Thr Lys Pro Ile Thr Ile Gly Arg His Ala His Gly 
                 165                170                175
Asp Gln Tyr Lys Ala Thr Asp Phe Val Ala Asp Arg Ala Gly Thr Phe 
             180                185                190
Lys Met Val Phe Thr Pro Lys Asp Gly Ser Gly Val Lys Glu Trp Glu 
         195                200                205
Val Tyr Asn Phe Pro Ala Gly Gly Val Gly Met Gly Met Tyr Asn Thr 
     210                215                220
Asp Glu Ser Ile Ser Gly Phe Ala His Ser Cys Phe Gln Tyr Ala Ile 
 225                230                235                240
Gln Lys Lys Trp Pro Leu Tyr Met Ser Thr Lys Asn Thr Ile Leu Lys 
                 245                250                255
Ala Tyr Asp Gly Arg Phe Lys Asp Ile Phe Gln Glu Ile Phe Asp Lys 
             260                265                270
His Tyr Lys Thr Asp Phe Asp Lys Asn Lys Ile Trp Tyr Glu His Arg 
         275                280                285
Leu Ile Asp Asp Met Val Ala Gln Val Leu Lys Ser Ser Gly Gly Phe 
     290                295                300
Val Trp Ala Cys Lys Asn Tyr Asp Gly Asp Val Gln Ser Asp Ile Leu 
 305                310                315                320
Ala Gln Gly Phe Gly Ser Leu Gly Leu Met Thr Ser Val Leu Val Cys 
                 325                330                335
Pro Asp Gly Lys Thr Ile Glu Ala Glu Ala Ala His Gly Thr Val Thr 
             340                345                350
Arg His Tyr Arg Glu His Gln Lys Gly Arg Pro Thr Ser Thr Asn Pro 
         355                360                365
Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Glu His Arg Gly Lys 
     370                375                380
Leu Asp Gly Asn Gln Asp Leu Ile Arg Phe Ala Gln Met Leu Glu Lys 
 385                390                395                400
Val Cys Val Glu Thr Val Glu Ser Gly Ala Met Thr Lys Asp Leu Ala 
                 405                410                415
Gly Cys Ile His Gly Leu Ser Asn Val Lys Leu Asn Glu His Phe Leu 
             420                425                430
Asn Thr Thr Asp Phe Leu Asp Thr Ile Lys Ser Asn Leu Asp Arg Ala 
         435                440                445
Leu Gly Arg Gln 
     450



<210> 5538
<211> 571
<212> DNA
<213> Rattus norvegicus
<308> AA891796
<400> 5538

aagaaccat  tctactctt  aggacaggg  caaagatcg  cctgtgcag  aagttggga  60
ctgcacaca  aactgcaga  gcaacattt  agctgaagc  ggggcctgg  gggagggag  120
gtcaggcaa  gagagggag  caactttag  tgccactcg  gtagtgtct  gtggtggtc  180
cagacagta  gctgtcttt  ggaagtgtg  atacacagg  ggtccattc  ctgcctaca  240
ccctggctg  ggtgccatc  aatcaatgt  actcaagtt  ctggccagc  aaactccag  300
agcaaagag  cccaaattg  ggatcaagt  cctccggaa  tcgttccga  cggtggcga  360
gcggtagac  ccgcgaagc  agtctccca  gttgtctgg  acctcggag  tctcaccgg  420
cgagccggc  gcgctcacc  tcacaccgc  ggaagccat  acagcaccg  gcacgtccg  480
accggcagc  cgtcgcacc  agtcggcgc  ggccgatcg  gcaacttcc  accccgcac  540
tccgccgat  agagtaata  gtgaacgag  a  571



<210> 5539
<211> 3316
<212> DNA
<213> Homo sapiens
<308> AL137721
<400> 5539

cttggggtg  ggaccgggt  aggggcctg  cggcagagt  ggtccagaa  tgcccggac  60
gcgacgcac  gcgaggagc  aaaatggaa  agggtgcaa  tcccctcct  gggccccag  120
cgccccctc  tttcttgct  cctggagca  gggcagtgc  gttagtggc  actcctggt  180
tgaacagcc  atcctggcc  ccttccaca  gaaacctga  ctgaaggac  gaagaggaa  240
gaagcaggc  ttgccacaa  tgtcagtgc  gaactctgg  tggccccac  aagaagaca  300
ccccaagcc  caggatcca  gtccaccag  caactcaga  agtgactca  gccacctgc  360
gggggagga  cctgaggat  cccatgctc  ggaattcct  tctctgcac  tgcttagaa  420
atggggttt  gactttaaa  tcattcaca  gagtattca  tatctctcc  agggggtct  480
tattgtcaa  ccagactct  ggggctttg  ccccaaggc  tgaaggggg  taagaaggg  540
aagcataag  agggaagct  ttttggggt  tggggcctc  ccagcctcc  tcaaggaag  600
ccacacatg  aggcatcag  cagctatcc  tgcactcag  gaggatctg  aaggaggac  660
ctcccaaat  gagggcatg  ttagaagct  ctctagatt  gagaagagg  ggcaatgat  720
agggggaaa  aaggagaaa  gaaagaaaa  cctagtttc  ctcctcccc  tcttccatg  780
ctcctcagg  tcctgcagt  ctgagcttg  gttcccttt  cctggacac  aaccaagcc  840
ccaactgga  tggacttca  accctcctg  agcaactcc  tccgcagga  attgatgag  900
gctactgcc  ggcccttgg  gaggaggag  gggccgagc  gcagctctt  tgtgccagg  960
ggaagcagg  agccctggg  cagggggta  cccgcctgg  acttcccaa  cttgaagga  1020
acacctgtg  gaagtgtag  gagttgctg  agccagggg  gtacggagt  tttgcagcc  1080
gggcagggg  acagcgctg  tggcaccag  cttgctttg  ctgccaggc  tgtggccag  1140
ccctgataa  cctcatcta  ttctaccat  atggacaac  ctactgcgg  cgtcatcat  1200
cagagttgc  gcgcccgcg  tgcccggct  gtgaccagc  gatcttctc  tggcgctgc  1260
ccgaggcgg  gggacagcg  tggcatgag  accacttct  ttgccagga  tgcgccggg  1320
ctctgggcg  gggacgtta  gccctgcct  ggggaagcc  ctgctgccc  agctgcttc  1380
agaaccgct  ctcggatgc  ggctcgagc  gggccgggg  actggaagg  caggcattc  1440
ttggagcgc  cccaccgca  cccccagac  caagcctcg  ggcccgcag  tctcaccgc  1500
catccctgg  cggagcgtt  caagggccg  ccgaaccca  cccgcgccg  ggtcggggt  1560
gcggcgcca  actccctcc  aggcgcggg  ggcggacgc  ctctggtgg  ggcggggga  1620
cctggcgag  actctcggc  gcggcggcg  cgcgcacgg  ccaggggct  ggcggggcg  1680
gaggctggg  ctcaccccc  ctagctgcg  tgtaggtcc  gctccgcgg  tctgagacc  1740
gcgtttccg  cccggcccg  aacagggga  actggactc  accgaactg  aggaaggga  1800
caaacctcg  tgaactctg  aaccctctc  cgaacactc  ttgctgctg  cggcggttc  1860
agcctgcaa  ctcagaggg  gctgcctgg  tccagtccc  agcaggaga  ccgacctgg  1920
gacaaagcg  aggcaccca  agggcagga  caatgccgc  tggagacta  tcgtgatcc  1980
aaggacacc  ctttctcca  ctgctcctc  tcctctgac  cggaacctg  aggattttt  2040
ttaggcgag  gccttcccc  gtcctggaa  acccccgga  gcctccaag  agaggacag  2100
aacgcctct  agacgcact  caccatgtg  tagtggcgc  gctcagaga  gggatgtga  2160
tgggaggaa  ggggtctgt  aagcgggag  acaaggcta  cctccccct  acaatccta  2220
actgagacg  agtcaggcg  acgcccgca  gaggcggcg  ggtgacaag  ttggagtgc  2280
cccccttca  tactgcgcg  tctaagact  ttggcggag  ctttcttgg  aaaacccat  2340
ccccaaagc  acgcttccc  tgctgagat  gcccctacc  ccacctcca  aggctggga  2400
agccccgtc  ccaccatcc  cctcccaag  caattaaat  atcacagca  gcgtgacag  2460
taccggctg  agagccgga  gtgggaccg  gagcagggg  ccgtagaac  gggccgcgc  2520
cctcccctc  tagagttcg  ggaggcgca  cagagggcc  tccctcttc  ggatgtcgg  2580
ctaagcgaa  agcgccccc  ctgccggcc  gtagcagcc  gaagtgcca  accggaggt  2640
cgtcattca  cggcgacgc  gatacggtt  ctccagcga  gcccatgcg  agctttcca  2700
tatggcttc  agcactgtc  cggtgagcg  tgctggctc  gctaatgaa  ctcccgaaa  2760
accggacaa  gtgggagat  ggcttcggg  cgtctaccg  tttgccact  ataggaatg  2820
cttccggag  aacttgata  taaatttgg  actctttgc  gcgggagtt  ggctggcca  2880
gaacttgag  gacattgac  tcatggcac  tcagccagg  gtgtagcca  gtagttcta  2940
tgccacctg  cgtcttatc  tctgattgc  gacaaatgg  atcctgtgc  gaacccgaa  3000
cttccaaaa  acagcctac  atctgtgac  accacaaga  gtgccctga  ggcagctga  3060
gtttgattc  gatgggcac  tttcttccc  ttccctgcc  agtttcctt  tgttccttg  3120
gtccacgca  aattccatt  tctggtcag  agacaggct  aagctaaag  attgcctct  3180
ttctgtaaa  ttctgtaca  agttcccaa  cttctgcag  gggtgattt  tgctcttgt  3240
ctgagaaat  acagtgctg  tttaaaaaa  atttgaaat  aataccgca  acaaaggaa  3300
aaaaaaaaa  aaaaaa  3316



<210> 5540
<211> 313
<212> PRT
<213> Homo sapiens
<308> AL137721
<400> 5540

Met Ser Pro Gln Gly Pro Ala Val Leu Ser Leu Gly Ser Leu Cys Leu 
  1               5                  10                  15
Asp Thr Asn Gln Ala Pro Asn Trp Thr Gly Leu Gln Thr Leu Leu Gln 
             20                  25                  30
Gln Leu Pro Pro Gln Asp Ile Asp Glu Arg Tyr Cys Leu Ala Leu Gly 
         35                  40                  45
Glu Glu Glu Arg Ala Glu Leu Gln Leu Phe Cys Ala Arg Arg Lys Gln 
     50                  55                  60
Glu Ala Leu Gly Gln Gly Val Ala Arg Leu Val Leu Pro Lys Leu Glu 
 65                  70                  75                  80
Gly His Thr Cys Glu Lys Cys Arg Glu Leu Leu Lys Pro Gly Glu Tyr 
                 85                  90                  95
Gly Val Phe Ala Ala Arg Ala Gly Glu Gln Arg Cys Trp His Gln Pro 
             100                105                110
Cys Phe Ala Cys Gln Ala Cys Gly Gln Ala Leu Ile Asn Leu Ile Tyr 
         115                120                125
Phe Tyr His Asp Gly Gln Leu Tyr Cys Gly Arg His His Ala Glu Leu 
     130                135                140
Leu Arg Pro Arg Cys Pro Ala Cys Asp Gln Leu Ile Phe Ser Trp Arg 
 145                150                155                160
Cys Thr Glu Ala Glu Gly Gln Arg Trp His Glu Asn His Phe Cys Cys 
                 165                170                175
Gln Asp Cys Ala Gly Pro Leu Gly Gly Gly Arg Tyr Ala Leu Pro Gly 
             180                185                190
Gly Ser Pro Cys Cys Pro Ser Cys Phe Glu Asn Arg Tyr Ser Asp Ala 
         195                200                205
Gly Ser Ser Trp Ala Gly Ala Leu Glu Gly Gln Ala Phe Leu Gly Ala 
     210                215                220
Pro Pro Pro His Pro Pro Asp Pro Ser Leu Gly Ala Arg Ser Ser His 
 225                230                235                240
Arg Ala Ser Leu Ala Gly Ala Phe Gln Gly Pro Pro Glu Pro Thr Pro 
                 245                250                255
Arg Arg Gly Arg Gly Cys Gly Ala Arg Leu Pro Pro Arg Arg Gly Arg 
             260                265                270
Arg Thr Pro Ser Gly Gly Gly Gly Gly Pro Trp Arg Gly Leu Ser Ala 
         275                280                285
Ala Ala Ala Ala Arg Thr Ala Gln Gly Leu Gly Gly Ala Gly Gly Trp 
     290                295                300
Ala Ser Pro Pro Leu Ala Ala Val Ter 
 305                310



<210> 5541
<211> 620
<212> DNA
<213> Rattus norvegicus
<308> AA891800
<400> 5541

aaaaagttt  aacaatgat  tcggacagg  agttatcag  cggtcatcc  cttgcttca  60
aagagcact  aaggaaaag  agtccccgg  gtcctcgga  gtttaaagt  tcagtgcag  120
agccccaga  tccccatca  ttgcggagg  agtgccaca  ttcttcttc  acactgctt  180
ctttactca  tgaaggtgt  gggatcgat  caactagtg  ccttgcttc  tctgtagtg  240
agtggaaag  gctatcaca  atgtgcacg  tcacacaac  gatagctcc  ttgtcacac  300
tcttcatca  catctcttt  caatgttca  gtgcagagt  aataacttc  agggcaaaa  360
ccttgtttt  gaattctcc  ttaaaagca  acttgtttt  tggttttcc  tctggtacc  420
tatagagtc  aaaccaatt  acagtggct  ctaggtaac  tggtttgaa  ttcttaaca  480
catcaatat  atgaaattt  tcagcctca  gatcattca  attgatagc  attattttc  540
aatctgttt  actctgatc  ataagtgcc  aagtcccca  gatcttcac  tggaccacg  600
ctccacggg  aagaaccttg  620



<210> 5542
<211> 330
<212> PRT
<213> Rattus norvegicus
<308> AAH11417
<400> 5542

Met Arg Ala Leu Leu Pro Leu Leu Ser Val Gly Arg Gly Trp Arg Val 
  1               5                  10                  15
Gly Ala Ala Ala Arg Pro Pro Arg Arg Val Met Ser Leu Tyr Arg Thr 
             20                  25                  30
Glu Glu Leu Gly His Pro Arg Ser Gln Asp Tyr Arg Leu Phe Phe Lys 
         35                  40                  45
His Val Ala Gly His Tyr Ile Ser Pro Phe His Asp Ile Pro Leu Lys 
     50                  55                  60
Ala Asp Cys Lys Glu Glu His Asp Ile Pro Arg Lys Lys Ala Arg Asn 
 65                  70                  75                  80
Asp Glu Tyr Glu Asn Leu Phe Asn Met Val Val Glu Ile Pro Arg Trp 
                 85                  90                  95
Thr Asn Ala Lys Met Glu Ile Ala Thr Glu Glu Pro Leu Asn Pro Ile 
             100                105                110
Lys Gln Asp Ile Lys Asn Gly Lys Leu Arg Tyr Thr Pro Asn Ile Phe 
         115                120                125
Pro His Lys Gly Tyr Ile Trp Asn Tyr Gly Ala Leu Pro Gln Thr Trp 
     130                135                140
Glu Asp Pro His Leu Arg Asp Lys Ser Thr Asp Cys Cys Gly Asp Asn 
 145                150                155                160
Asp Pro Ile Asp Val Cys Glu Ile Gly Ser Lys Val Leu Ser Arg Gly 
                 165                170                175
Asp Val Val His Val Lys Ile Leu Gly Thr Leu Ala Leu Ile Asp Gln 
             180                185                190
Ser Glu Thr Asp Trp Lys Ile Ile Ala Ile Asn Val Asn Asp Pro Glu 
         195                200                205
Ala Glu Lys Phe His Asp Ile Asp Asp Val Lys Lys Phe Lys Pro Gly 
     210                215                220
Tyr Leu Glu Ala Thr Leu Asn Trp Phe Arg Leu Tyr Lys Val Pro Asp 
 225                230                235                240
Gly Lys Pro Glu Asn Lys Phe Ala Phe Asn Gly Glu Phe Lys Asn Lys 
                 245                250                255
Ala Phe Ala Leu Asp Val Ile Asn Ser Ala His Glu Arg Trp Lys Glu 
             260                265                270
Met Val Met Lys Lys Cys Asp Lys Gly Ala Ile Ser Cys Val Asn Val 
         275                280                285
His Ile Cys Asp Ser Pro Phe His Cys Thr Met Glu Glu Ala Arg Ser 
     290                295                300
Leu Val Glu Ser Val Pro Thr Pro Ser Met Asn Lys Glu Ser Asn Val 
 305                310                315                320
Glu Glu Glu Val Trp His Phe Leu Arg Asn 
                 325                330



<210> 5543
<211> 1214
<212> DNA
<213> Homo sapiens
<308> AF217187
<400> 5543

ccgtcattg  cgccatgag  gcgctgctg  ggctgctgc  cacggttgc  ccagccgct  60
cgtgcctgc  gttggggac  agtgcaggg  ccgggtcgc  ccgtgctat  gccctgtac  120
acactgagg  gcgcggcca  ccctgctcg  agaattacc  cctcttctt  aagaatgta  180
ctggtcact  catttcccc  tttcatgat  ttcctctga  ggtgaactc  aaagaggaa  240
atggcattc  tatgaagaa  gcacgaaat  atgaatatg  gaatctgtt  aatatgatt  300
tagaaatac  tcggtggac  aatgctaaa  tggagattg  caccaagga  ccaatgaat  360
ccattaaac  atatgtaaa  gatggaaag  tacgctatg  ggcgaatat  ttcccttac  420
agggttata  atggaatta  ggtaccctc  ctcagactt  ggaagatcc  catgaaaaa  480
ataagagca  gaactgctt  ggagataat  atcctattg  tgtttgcga  ataggctca  540
agattcttt  ttgtggaga  gttattcat  tgaagatcc  tggaatttt  gctcttatt  600
atgaaggtg  aacagattg  aaattaatt  ctatcaatg  gaatgatcc  gaagcctca  660
agtttcatg  tattgatga  gttaagaag  tcaaaccgg  ttacctgga  gctactctt  720
attggttta  attatataa  gtaccagat  gaaaaccag  aaaccagtt  gcttttaat  780
gagaattca  aaacaaggc  tttgctctt  aagttatta  atccactca  caatgttgg  840
aagcattgc  tatgaagaa  tgtaatgga  gagctataa  ttgcacaaa  gtgcagata  900
ctgatagcc  tttccgttg  actcaagag  aagcaagat  attagttga  tcggtatca  960
cttcaccaa  taaagaaag  aatgaagaa  agcaagtgt  gcacttcct  ggcaagtga  1020
tgaaacatc  gaaattctg  tgtcaagat  cccatctct  aggactcca  gtgctagag  1080
caagggggt  tatgagcat  tactgactt  ctgttaaaa  ttcattttt  caaactttt  1140
gagctatgc  atatataaa  aaacagtaa  aattttaaa  aaaaaaaaa  aaaaaaaaa  1200
aaaaaaaaa  aaaa  1214



<210> 5544
<211> 334
<212> PRT
<213> Homo sapiens
<308> AAG36781
<400> 5544

Met Ser Ala Leu Leu Arg Leu Leu Arg Thr Val Ala Pro Ala Ala Ala 
  1               5                  10                  15
Cys Leu Arg Leu Gly Thr Ser Ala Gly Thr Gly Ser Arg Arg Ala Met 
             20                  25                  30
Ala Leu Tyr His Thr Glu Glu Arg Gly Gln Pro Cys Ser Gln Asn Tyr 
         35                  40                  45
Arg Leu Phe Phe Lys Asn Val Thr Gly His Tyr Ile Ser Pro Phe His 
     50                  55                  60
Asp Ile Pro Leu Lys Val Asn Ser Lys Glu Glu Asn Gly Ile Pro Met 
 65                  70                  75                  80
Lys Lys Ala Arg Asn Asp Glu Tyr Glu Asn Leu Phe Asn Met Ile Val 
                 85                  90                  95
Glu Ile Pro Arg Trp Thr Asn Ala Lys Met Glu Ile Ala Thr Lys Glu 
             100                105                110
Pro Met Asn Pro Ile Lys Gln Tyr Val Lys Asp Gly Lys Leu Arg Tyr 
         115                120                125
Val Ala Asn Ile Phe Pro Tyr Lys Gly Tyr Ile Trp Asn Tyr Gly Thr 
     130                135                140
Leu Pro Gln Thr Trp Glu Asp Pro His Glu Lys Asp Lys Ser Thr Asn 
 145                150                155                160
Cys Phe Gly Asp Asn Asp Pro Ile Asp Val Cys Glu Ile Gly Ser Lys 
                 165                170                175
Ile Leu Ser Cys Gly Glu Val Ile His Val Lys Ile Leu Gly Ile Leu 
             180                185                190
Ala Leu Ile Asp Glu Gly Glu Thr Asp Trp Lys Leu Ile Ala Ile Asn 
         195                200                205
Ala Asn Asp Pro Glu Ala Ser Lys Phe His Asp Ile Asp Asp Val Lys 
     210                215                220
Lys Phe Lys Pro Gly Tyr Leu Glu Ala Thr Leu Asn Trp Phe Arg Leu 
 225                230                235                240
Tyr Lys Val Pro Asp Gly Lys Pro Glu Asn Gln Phe Ala Phe Asn Gly 
                 245                250                255
Glu Phe Lys Asn Lys Ala Phe Ala Leu Glu Val Ile Lys Ser Thr His 
             260                265                270
Gln Cys Trp Lys Ala Leu Leu Met Lys Lys Cys Asn Gly Gly Ala Ile 
         275                280                285
Asn Cys Thr Asn Val Gln Ile Ser Asp Ser Pro Phe Arg Cys Thr Gln 
     290                295                300
Glu Glu Ala Arg Ser Leu Val Glu Ser Val Ser Ser Ser Pro Asn Lys 
 305                310                315                320
Glu Ser Asn Glu Glu Glu Gln Val Trp His Phe Leu Gly Lys 
                 325                330



<210> 5545
<211> 620
<212> DNA
<213> Rattus norvegicus
<308> AA891800
<400> 5545

aaaaagttt  aacaatgat  tcggacagg  agttatcag  cggtcatcc  cttgcttca  60
aagagcact  aaggaaaag  agtccccgg  gtcctcgga  gtttaaagt  tcagtgcag  120
agccccaga  tccccatca  ttgcggagg  agtgccaca  ttcttcttc  acactgctt  180
ctttactca  tgaaggtgt  gggatcgat  caactagtg  ccttgcttc  tctgtagtg  240
agtggaaag  gctatcaca  atgtgcacg  tcacacaac  gatagctcc  ttgtcacac  300
tcttcatca  catctcttt  caatgttca  gtgcagagt  aataacttc  agggcaaaa  360
ccttgtttt  gaattctcc  ttaaaagca  acttgtttt  tggttttcc  tctggtacc  420
tatagagtc  aaaccaatt  acagtggct  ctaggtaac  tggtttgaa  ttcttaaca  480
catcaatat  atgaaattt  tcagcctca  gatcattca  attgatagc  attattttc  540
aatctgttt  actctgatc  ataagtgcc  aagtcccca  gatcttcac  tggaccacg  600
ctccacggg  aagaaccttg  620



<210> 5546
<211> 330
<212> PRT
<213> Rattus norvegicus
<308> AAH11417
<400> 5546

Met Arg Ala Leu Leu Pro Leu Leu Ser Val Gly Arg Gly Trp Arg Val 
  1               5                  10                  15
Gly Ala Ala Ala Arg Pro Pro Arg Arg Val Met Ser Leu Tyr Arg Thr 
             20                  25                  30
Glu Glu Leu Gly His Pro Arg Ser Gln Asp Tyr Arg Leu Phe Phe Lys 
         35                  40                  45
His Val Ala Gly His Tyr Ile Ser Pro Phe His Asp Ile Pro Leu Lys 
     50                  55                  60
Ala Asp Cys Lys Glu Glu His Asp Ile Pro Arg Lys Lys Ala Arg Asn 
 65                  70                  75                  80
Asp Glu Tyr Glu Asn Leu Phe Asn Met Val Val Glu Ile Pro Arg Trp 
                 85                  90                  95
Thr Asn Ala Lys Met Glu Ile Ala Thr Glu Glu Pro Leu Asn Pro Ile 
             100                105                110
Lys Gln Asp Ile Lys Asn Gly Lys Leu Arg Tyr Thr Pro Asn Ile Phe 
         115                120                125
Pro His Lys Gly Tyr Ile Trp Asn Tyr Gly Ala Leu Pro Gln Thr Trp 
     130                135                140
Glu Asp Pro His Leu Arg Asp Lys Ser Thr Asp Cys Cys Gly Asp Asn 
 145                150                155                160
Asp Pro Ile Asp Val Cys Glu Ile Gly Ser Lys Val Leu Ser Arg Gly 
                 165                170                175
Asp Val Val His Val Lys Ile Leu Gly Thr Leu Ala Leu Ile Asp Gln 
             180                185                190
Ser Glu Thr Asp Trp Lys Ile Ile Ala Ile Asn Val Asn Asp Pro Glu 
         195                200                205
Ala Glu Lys Phe His Asp Ile Asp Asp Val Lys Lys Phe Lys Pro Gly 
     210                215                220
Tyr Leu Glu Ala Thr Leu Asn Trp Phe Arg Leu Tyr Lys Val Pro Asp 
 225                230                235                240
Gly Lys Pro Glu Asn Lys Phe Ala Phe Asn Gly Glu Phe Lys Asn Lys 
                 245                250                255
Ala Phe Ala Leu Asp Val Ile Asn Ser Ala His Glu Arg Trp Lys Glu 
             260                265                270
Met Val Met Lys Lys Cys Asp Lys Gly Ala Ile Ser Cys Val Asn Val 
         275                280                285
His Ile Cys Asp Ser Pro Phe His Cys Thr Met Glu Glu Ala Arg Ser 
     290                295                300
Leu Val Glu Ser Val Pro Thr Pro Ser Met Asn Lys Glu Ser Asn Val 
 305                310                315                320
Glu Glu Glu Val Trp His Phe Leu Arg Asn 
                 325                330



<210> 5547
<211> 1214
<212> DNA
<213> Homo sapiens
<308> AF217187
<400> 5547

ccgtcattg  cgccatgag  gcgctgctg  ggctgctgc  cacggttgc  ccagccgct  60
cgtgcctgc  gttggggac  agtgcaggg  ccgggtcgc  ccgtgctat  gccctgtac  120
acactgagg  gcgcggcca  ccctgctcg  agaattacc  cctcttctt  aagaatgta  180
ctggtcact  catttcccc  tttcatgat  ttcctctga  ggtgaactc  aaagaggaa  240
atggcattc  tatgaagaa  gcacgaaat  atgaatatg  gaatctgtt  aatatgatt  300
tagaaatac  tcggtggac  aatgctaaa  tggagattg  caccaagga  ccaatgaat  360
ccattaaac  atatgtaaa  gatggaaag  tacgctatg  ggcgaatat  ttcccttac  420
agggttata  atggaatta  ggtaccctc  ctcagactt  ggaagatcc  catgaaaaa  480
ataagagca  gaactgctt  ggagataat  atcctattg  tgtttgcga  ataggctca  540
agattcttt  ttgtggaga  gttattcat  tgaagatcc  tggaatttt  gctcttatt  600
atgaaggtg  aacagattg  aaattaatt  ctatcaatg  gaatgatcc  gaagcctca  660
agtttcatg  tattgatga  gttaagaag  tcaaaccgg  ttacctgga  gctactctt  720
attggttta  attatataa  gtaccagat  gaaaaccag  aaaccagtt  gcttttaat  780
gagaattca  aaacaaggc  tttgctctt  aagttatta  atccactca  caatgttgg  840
aagcattgc  tatgaagaa  tgtaatgga  gagctataa  ttgcacaaa  gtgcagata  900
ctgatagcc  tttccgttg  actcaagag  aagcaagat  attagttga  tcggtatca  960
cttcaccaa  taaagaaag  aatgaagaa  agcaagtgt  gcacttcct  ggcaagtga  1020
tgaaacatc  gaaattctg  tgtcaagat  cccatctct  aggactcca  gtgctagag  1080
caagggggt  tatgagcat  tactgactt  ctgttaaaa  ttcattttt  caaactttt  1140
gagctatgc  atatataaa  aaacagtaa  aattttaaa  aaaaaaaaa  aaaaaaaaa  1200
aaaaaaaaa  aaaa  1214



<210> 5548
<211> 334
<212> PRT
<213> Homo sapiens
<308> AAG36781
<400> 5548

Met Ser Ala Leu Leu Arg Leu Leu Arg Thr Val Ala Pro Ala Ala Ala 
  1               5                  10                  15
Cys Leu Arg Leu Gly Thr Ser Ala Gly Thr Gly Ser Arg Arg Ala Met 
             20                  25                  30
Ala Leu Tyr His Thr Glu Glu Arg Gly Gln Pro Cys Ser Gln Asn Tyr 
         35                  40                  45
Arg Leu Phe Phe Lys Asn Val Thr Gly His Tyr Ile Ser Pro Phe His 
     50                  55                  60
Asp Ile Pro Leu Lys Val Asn Ser Lys Glu Glu Asn Gly Ile Pro Met 
 65                  70                  75                  80
Lys Lys Ala Arg Asn Asp Glu Tyr Glu Asn Leu Phe Asn Met Ile Val 
                 85                  90                  95
Glu Ile Pro Arg Trp Thr Asn Ala Lys Met Glu Ile Ala Thr Lys Glu 
             100                105                110
Pro Met Asn Pro Ile Lys Gln Tyr Val Lys Asp Gly Lys Leu Arg Tyr 
         115                120                125
Val Ala Asn Ile Phe Pro Tyr Lys Gly Tyr Ile Trp Asn Tyr Gly Thr 
     130                135                140
Leu Pro Gln Thr Trp Glu Asp Pro His Glu Lys Asp Lys Ser Thr Asn 
 145                150                155                160
Cys Phe Gly Asp Asn Asp Pro Ile Asp Val Cys Glu Ile Gly Ser Lys 
                 165                170                175
Ile Leu Ser Cys Gly Glu Val Ile His Val Lys Ile Leu Gly Ile Leu 
             180                185                190
Ala Leu Ile Asp Glu Gly Glu Thr Asp Trp Lys Leu Ile Ala Ile Asn 
         195                200                205
Ala Asn Asp Pro Glu Ala Ser Lys Phe His Asp Ile Asp Asp Val Lys 
     210                215                220
Lys Phe Lys Pro Gly Tyr Leu Glu Ala Thr Leu Asn Trp Phe Arg Leu 
 225                230                235                240
Tyr Lys Val Pro Asp Gly Lys Pro Glu Asn Gln Phe Ala Phe Asn Gly 
                 245                250                255
Glu Phe Lys Asn Lys Ala Phe Ala Leu Glu Val Ile Lys Ser Thr His 
             260                265                270
Gln Cys Trp Lys Ala Leu Leu Met Lys Lys Cys Asn Gly Gly Ala Ile 
         275                280                285
Asn Cys Thr Asn Val Gln Ile Ser Asp Ser Pro Phe Arg Cys Thr Gln 
     290                295                300
Glu Glu Ala Arg Ser Leu Val Glu Ser Val Ser Ser Ser Pro Asn Lys 
 305                310                315                320
Glu Ser Asn Glu Glu Glu Gln Val Trp His Phe Leu Gly Lys 
                 325                330



<210> 5549
<211> 648
<212> DNA
<213> Rattus norvegicus
<308> AA891802
<400> 5549

aactacatg  gcatacaga  aatattcaa  gaaaaatgc  aaccacaca  ctgacatgt  60
aatcatttc  aacaaccat  aaaacactt  ttgctctgc  ctttagaaa  ttattttta  120
tgttttgta  atgtctcac  ttgggcaaa  tgagggatg  ggtgctcac  ggaagtggg  180
atgagacag  tggaaggag  gggcggcct  gcttagcct  tgcaacccc  tctggcagc  240
tcccctaca  ctactgagg  tgaaccccc  ctcccatcc  cagagacaa  agacaaaga  300
ccaggttag  acagcaaga  aacaagatt  tggacacaa  ccagtagat  tggtgcccc  360
ccaccccta  ataaagggc  cacagtgac  gtgccgaaa  gtttatatg  cagtcccta  420
catagctaa  agacatact  gtcttctcc  tgtttggtt  ctctaggct  aaggctcaa  480
tgctgtaca  agtcataag  gtgtggcca  actgagcat  atgagggaa  gtttagccg  540
tctcctggg  acccttaga  acactatac  cctaggcgg  tctcaccca  gctcagccc  600
taaccctat  tataccttg  ggtatacct  tcagctgca  acacaaat  648



<210> 5550
<211> 551
<212> DNA
<213> Rattus norvegicus
<308> AA891810
<400> 5550

aatacaaag  tttggcatt  gcaatttta  gaaaaaata  aatgtacta  aaataaacg  60
ttgtgtggc  tgattggta  atgatgcac  aaaataggt  cttttttcc  tcaaggcaa  120
cagtcagaa  gcagtgttt  ccttcttca  aaccattct  ccttgttac  gcaatgttg  180
tttcacccg  tcgaggagt  agctcccca  cttgaggaa  aggcgatat  ccagaagtt  240
tcagtggct  aaggccaag  gaactgtca  tggcaaggt  accaagggc  gatcttcgg  300
taactgcct  ggttctggt  agcctttcc  tatcaaacg  tacattatc  gtacatggc  360
gatttggca  aattcctag  gctttcaaa  tattaagtt  acacatagg  caggtacag  420
gttcactga  ccagggatc  acacaggat  tgtggaaaa  atgcttgca  gggagaacc  480
gaacaacat  attctgctt  tagctctct  tgcagactg  acagtgatc  aagtctggg  540
ctgtttcct  a  551



<210> 5551
<211> 419
<212> PRT
<213> Rattus norvegicus
<308> NP_067515
<400> 5551

Met Ser Gly Ala Ala Arg Ala Gly Pro Ala Arg Leu Ala Ala Leu Ala 
  1               5                  10                  15
Leu Leu Thr Cys Ser Leu Trp Pro Thr Arg Ala Asp Asn Ala Ser Gln 
             20                  25                  30
Glu Tyr Tyr Thr Ala Leu Ile Asn Val Thr Val Gln Glu Pro Gly Arg 
         35                  40                  45
Gly Thr Pro Leu Thr Phe Arg Ile Asp Arg Gly Arg Tyr Gly Leu Asp 
     50                  55                  60
Ser Pro Lys Ala Glu Val Arg Gly Gln Val Leu Ala Pro Leu Pro Ile 
 65                  70                  75                  80
His Gly Val Ala Asp His Leu Gly Cys Asp Pro Gln Thr Arg Phe Phe 
                 85                  90                  95
Val Pro Pro Asn Ile Lys Gln Trp Ile Ala Leu Leu Gln Arg Gly Asn 
             100                105                110
Cys Thr Phe Lys Glu Lys Ile Ser Arg Ala Ala Phe His Asn Ala Val 
         115                120                125
Ala Val Val Ile Tyr Asn Asn Lys Ser Lys Glu Glu Pro Val Thr Met 
     130                135                140
Thr His Pro Gly Thr Gly Asp Ile Ile Ala Val Met Ile Thr Glu Leu 
 145                150                155                160
Arg Gly Lys Asp Ile Leu Ser Tyr Leu Glu Lys Asn Ile Ser Val Gln 
                 165                170                175
Met Thr Ile Ala Val Gly Thr Arg Met Pro Pro Lys Asn Phe Ser Arg 
             180                185                190
Gly Ser Leu Val Phe Val Ser Ile Ser Phe Ile Val Leu Met Ile Ile 
         195                200                205
Ser Ser Ala Trp Leu Ile Phe Tyr Phe Ile Gln Lys Ile Arg Tyr Thr 
     210                215                220
Asn Ala Arg Asp Arg Asn Gln Arg Arg Leu Gly Asp Ala Ala Lys Lys 
 225                230                235                240
Ala Ile Ser Lys Leu Thr Thr Arg Thr Val Lys Lys Gly Asp Lys Glu 
                 245                250                255
Thr Asp Pro Asp Phe Asp His Cys Ala Val Cys Ile Glu Ser Tyr Lys 
             260                265                270
Gln Asn Asp Val Val Arg Val Leu Pro Cys Lys His Val Phe His Lys 
         275                280                285
Ser Cys Val Asp Pro Trp Leu Ser Glu His Cys Thr Cys Pro Met Cys 
     290                295                300
Lys Leu Asn Ile Leu Arg Ala Leu Gly Ile Val Pro Asn Leu Pro Cys 
 305                310                315                320
Thr Asp Asn Val Ala Phe Asp Met Glu Arg Leu Thr Arg Thr Gln Ala 
                 325                330                335
Val Asn Arg Arg Ala Ala Leu Gly Asp Leu Ala Gly Asp Ser Ser Leu 
             340                345                350
Gly Leu Glu Pro Leu Arg Thr Ser Gly Ile Ser Pro Leu Pro Gln Asp 
         355                360                365
Gly Glu Leu Thr Pro Arg Thr Gly Glu Ile Asn Ile Ala Val Thr Lys 
     370                375                380
Glu Trp Phe Ile Ile Ala Ser Phe Gly Leu Leu Ser Ala Leu Thr Leu 
 385                390                395                400
Cys Tyr Met Ile Ile Arg Ala Thr Ala Ser Leu Asn Ala Asn Glu Val 
                 405                410                415
Glu Trp Phe 
             420



<210> 5552
<211> 1153
<212> DNA
<213> Homo sapiens
<308> AF155650
<400> 5552

ggttcttgt  ctcctaata  caacagtgg  ttgccttgc  gcagagggg  actgcacgt  60
taagagaaa  tatcacggg  cgctttcca  aatgcagtt  ctgtagtca  ctacactaa  120
aaatccaaa  aggagccag  taccatgac  catccaggc  ctggagata  tattgctgt  180
atgataaca  aattgaggg  taaggatat  ttgagttat  tggagaaaa  catctctgt  240
caaatgaca  tagctgttg  aactcgaat  ccaccgaag  acttcagcc  tggctctct  300
gtcttcgtg  caatatcct  tattgtttt  atgattatt  cttcagcat  gctcatatt  360
tacttcatt  agaagatca  gtacacaaa  gcacgcgac  ggaaccagc  tcgtctcgg  420
gatgcagcc  agaaagcca  cagtaaatt  acaaccagg  cagtaaaga  gggtgacaa  480
gaaactgac  cagactttg  tcattgtgc  gtctgcata  agagctata  gcagaatga  540
gtcgtccga  ttctcccct  caagcatgt  ttccacaaa  cctgcgtgg  tccctggct  600
agtgaacat  gtacctgtc  tatgtgcaa  cttaatata  tgaaggccc  gggaattgt  660
ccgaatttg  catgtactg  taacgtagc  ttcgatatg  aaaggctca  cagaaccca  720
gctgttaac  gaagatcag  cctcggcga  ctcgccggc  acaactccc  tggccttga  780
ccacttcga  cttcgggga  ctcacctct  cctcaggat  gggagctca  tccgagaac  840
ggagaaatc  acattgcag  aacaaaaga  tggtttatt  ttgccagtt  tggcctcct  900
agtgccctc  cactctgct  catgatcat  agagccaca  ctagcttga  tgctaatga  960
gtagaatgg  tttgaagaa  aaaaaacct  ctttctgac  gattttgcc  tgaaggaaa  1020
aagaaccta  ttttgtgca  catttacca  tcatgccac  caagcattt  tttttagta  1080
attttattt  ttcataaaa  tgctaatgc  aaagctttg  attaaaaga  ataaataat  1140
aaataaaaa  aaa  1153



<210> 5553
<211> 276
<212> PRT
<213> Homo sapiens
<308> NP_060904
<400> 5553

Met Thr His Pro Gly Thr Gly Asp Ile Ile Ala Val Met Ile Thr Glu 
  1               5                  10                  15
Leu Arg Gly Lys Asp Ile Leu Ser Tyr Leu Glu Lys Asn Ile Ser Val 
             20                  25                  30
Gln Met Thr Ile Ala Val Gly Thr Arg Met Pro Pro Lys Asn Phe Ser 
         35                  40                  45
Arg Gly Ser Leu Val Phe Val Ser Ile Ser Phe Ile Val Leu Met Ile 
     50                  55                  60
Ile Ser Ser Ala Trp Leu Ile Phe Tyr Phe Ile Gln Lys Ile Arg Tyr 
 65                  70                  75                  80
Thr Asn Ala Arg Asp Arg Asn Gln Arg Arg Leu Gly Asp Ala Ala Lys 
                 85                  90                  95
Lys Ala Ile Ser Lys Leu Thr Thr Arg Thr Val Lys Lys Gly Asp Lys 
             100                105                110
Glu Thr Asp Pro Asp Phe Asp His Cys Ala Val Cys Ile Glu Ser Tyr 
         115                120                125
Lys Gln Asn Asp Val Val Arg Ile Leu Pro Cys Lys His Val Phe His 
     130                135                140
Lys Ser Cys Val Asp Pro Trp Leu Ser Glu His Cys Thr Cys Pro Met 
 145                150                155                160
Cys Lys Leu Asn Ile Leu Lys Ala Leu Gly Ile Val Pro Asn Leu Pro 
                 165                170                175
Cys Thr Asp Asn Val Ala Phe Asp Met Glu Arg Leu Thr Arg Thr Gln 
             180                185                190
Ala Val Asn Arg Arg Ser Ala Leu Gly Asp Leu Ala Gly Asp Asn Ser 
         195                200                205
Leu Gly Leu Glu Pro Leu Arg Thr Ser Gly Ile Ser Pro Leu Pro Gln 
     210                215                220
Asp Gly Glu Leu Thr Pro Arg Thr Gly Glu Ile Asn Ile Ala Val Thr 
 225                230                235                240
Lys Glu Trp Phe Ile Ile Ala Ser Phe Gly Leu Leu Ser Ala Leu Thr 
                 245                250                255
Leu Cys Tyr Met Ile Ile Arg Ala Thr Ala Ser Leu Asn Ala Asn Glu 
             260                265                270
Val Glu Trp Phe 
         275



<210> 5554
<211> 551
<212> DNA
<213> Rattus norvegicus
<308> AA891810
<400> 5554

aatacaaag  tttggcatt  gcaatttta  gaaaaaata  aatgtacta  aaataaacg  60
ttgtgtggc  tgattggta  atgatgcac  aaaataggt  cttttttcc  tcaaggcaa  120
cagtcagaa  gcagtgttt  ccttcttca  aaccattct  ccttgttac  gcaatgttg  180
tttcacccg  tcgaggagt  agctcccca  cttgaggaa  aggcgatat  ccagaagtt  240
tcagtggct  aaggccaag  gaactgtca  tggcaaggt  accaagggc  gatcttcgg  300
taactgcct  ggttctggt  agcctttcc  tatcaaacg  tacattatc  gtacatggc  360
gatttggca  aattcctag  gctttcaaa  tattaagtt  acacatagg  caggtacag  420
gttcactga  ccagggatc  acacaggat  tgtggaaaa  atgcttgca  gggagaacc  480
gaacaacat  attctgctt  tagctctct  tgcagactg  acagtgatc  aagtctggg  540
ctgtttcct  a  551



<210> 5555
<211> 419
<212> PRT
<213> Rattus norvegicus
<308> NP_067515
<400> 5555

Met Ser Gly Ala Ala Arg Ala Gly Pro Ala Arg Leu Ala Ala Leu Ala 
  1               5                  10                  15
Leu Leu Thr Cys Ser Leu Trp Pro Thr Arg Ala Asp Asn Ala Ser Gln 
             20                  25                  30
Glu Tyr Tyr Thr Ala Leu Ile Asn Val Thr Val Gln Glu Pro Gly Arg 
         35                  40                  45
Gly Thr Pro Leu Thr Phe Arg Ile Asp Arg Gly Arg Tyr Gly Leu Asp 
     50                  55                  60
Ser Pro Lys Ala Glu Val Arg Gly Gln Val Leu Ala Pro Leu Pro Ile 
 65                  70                  75                  80
His Gly Val Ala Asp His Leu Gly Cys Asp Pro Gln Thr Arg Phe Phe 
                 85                  90                  95
Val Pro Pro Asn Ile Lys Gln Trp Ile Ala Leu Leu Gln Arg Gly Asn 
             100                105                110
Cys Thr Phe Lys Glu Lys Ile Ser Arg Ala Ala Phe His Asn Ala Val 
         115                120                125
Ala Val Val Ile Tyr Asn Asn Lys Ser Lys Glu Glu Pro Val Thr Met 
     130                135                140
Thr His Pro Gly Thr Gly Asp Ile Ile Ala Val Met Ile Thr Glu Leu 
 145                150                155                160
Arg Gly Lys Asp Ile Leu Ser Tyr Leu Glu Lys Asn Ile Ser Val Gln 
                 165                170                175
Met Thr Ile Ala Val Gly Thr Arg Met Pro Pro Lys Asn Phe Ser Arg 
             180                185                190
Gly Ser Leu Val Phe Val Ser Ile Ser Phe Ile Val Leu Met Ile Ile 
         195                200                205
Ser Ser Ala Trp Leu Ile Phe Tyr Phe Ile Gln Lys Ile Arg Tyr Thr 
     210                215                220
Asn Ala Arg Asp Arg Asn Gln Arg Arg Leu Gly Asp Ala Ala Lys Lys 
 225                230                235                240
Ala Ile Ser Lys Leu Thr Thr Arg Thr Val Lys Lys Gly Asp Lys Glu 
                 245                250                255
Thr Asp Pro Asp Phe Asp His Cys Ala Val Cys Ile Glu Ser Tyr Lys 
             260                265                270
Gln Asn Asp Val Val Arg Val Leu Pro Cys Lys His Val Phe His Lys 
         275                280                285
Ser Cys Val Asp Pro Trp Leu Ser Glu His Cys Thr Cys Pro Met Cys 
     290                295                300
Lys Leu Asn Ile Leu Arg Ala Leu Gly Ile Val Pro Asn Leu Pro Cys 
 305                310                315                320
Thr Asp Asn Val Ala Phe Asp Met Glu Arg Leu Thr Arg Thr Gln Ala 
                 325                330                335
Val Asn Arg Arg Ala Ala Leu Gly Asp Leu Ala Gly Asp Ser Ser Leu 
             340                345                350
Gly Leu Glu Pro Leu Arg Thr Ser Gly Ile Ser Pro Leu Pro Gln Asp 
         355                360                365
Gly Glu Leu Thr Pro Arg Thr Gly Glu Ile Asn Ile Ala Val Thr Lys 
     370                375                380
Glu Trp Phe Ile Ile Ala Ser Phe Gly Leu Leu Ser Ala Leu Thr Leu 
 385                390                395                400
Cys Tyr Met Ile Ile Arg Ala Thr Ala Ser Leu Asn Ala Asn Glu Val 
                 405                410                415
Glu Trp Phe 
             420



<210> 5556
<211> 1153
<212> DNA
<213> Homo sapiens
<308> AF155650
<400> 5556

ggttcttgt  ctcctaata  caacagtgg  ttgccttgc  gcagagggg  actgcacgt  60
taagagaaa  tatcacggg  cgctttcca  aatgcagtt  ctgtagtca  ctacactaa  120
aaatccaaa  aggagccag  taccatgac  catccaggc  ctggagata  tattgctgt  180
atgataaca  aattgaggg  taaggatat  ttgagttat  tggagaaaa  catctctgt  240
caaatgaca  tagctgttg  aactcgaat  ccaccgaag  acttcagcc  tggctctct  300
gtcttcgtg  caatatcct  tattgtttt  atgattatt  cttcagcat  gctcatatt  360
tacttcatt  agaagatca  gtacacaaa  gcacgcgac  ggaaccagc  tcgtctcgg  420
gatgcagcc  agaaagcca  cagtaaatt  acaaccagg  cagtaaaga  gggtgacaa  480
gaaactgac  cagactttg  tcattgtgc  gtctgcata  agagctata  gcagaatga  540
gtcgtccga  ttctcccct  caagcatgt  ttccacaaa  cctgcgtgg  tccctggct  600
agtgaacat  gtacctgtc  tatgtgcaa  cttaatata  tgaaggccc  gggaattgt  660
ccgaatttg  catgtactg  taacgtagc  ttcgatatg  aaaggctca  cagaaccca  720
gctgttaac  gaagatcag  cctcggcga  ctcgccggc  acaactccc  tggccttga  780
ccacttcga  cttcgggga  ctcacctct  cctcaggat  gggagctca  tccgagaac  840
ggagaaatc  acattgcag  aacaaaaga  tggtttatt  ttgccagtt  tggcctcct  900
agtgccctc  cactctgct  catgatcat  agagccaca  ctagcttga  tgctaatga  960
gtagaatgg  tttgaagaa  aaaaaacct  ctttctgac  gattttgcc  tgaaggaaa  1020
aagaaccta  ttttgtgca  catttacca  tcatgccac  caagcattt  tttttagta  1080
attttattt  ttcataaaa  tgctaatgc  aaagctttg  attaaaaga  ataaataat  1140
aaataaaaa  aaa  1153



<210> 5557
<211> 276
<212> PRT
<213> Homo sapiens
<308> NP_060904
<400> 5557

Met Thr His Pro Gly Thr Gly Asp Ile Ile Ala Val Met Ile Thr Glu 
  1               5                  10                  15
Leu Arg Gly Lys Asp Ile Leu Ser Tyr Leu Glu Lys Asn Ile Ser Val 
             20                  25                  30
Gln Met Thr Ile Ala Val Gly Thr Arg Met Pro Pro Lys Asn Phe Ser 
         35                  40                  45
Arg Gly Ser Leu Val Phe Val Ser Ile Ser Phe Ile Val Leu Met Ile 
     50                  55                  60
Ile Ser Ser Ala Trp Leu Ile Phe Tyr Phe Ile Gln Lys Ile Arg Tyr 
 65                  70                  75                  80
Thr Asn Ala Arg Asp Arg Asn Gln Arg Arg Leu Gly Asp Ala Ala Lys 
                 85                  90                  95
Lys Ala Ile Ser Lys Leu Thr Thr Arg Thr Val Lys Lys Gly Asp Lys 
             100                105                110
Glu Thr Asp Pro Asp Phe Asp His Cys Ala Val Cys Ile Glu Ser Tyr 
         115                120                125
Lys Gln Asn Asp Val Val Arg Ile Leu Pro Cys Lys His Val Phe His 
     130                135                140
Lys Ser Cys Val Asp Pro Trp Leu Ser Glu His Cys Thr Cys Pro Met 
 145                150                155                160
Cys Lys Leu Asn Ile Leu Lys Ala Leu Gly Ile Val Pro Asn Leu Pro 
                 165                170                175
Cys Thr Asp Asn Val Ala Phe Asp Met Glu Arg Leu Thr Arg Thr Gln 
             180                185                190
Ala Val Asn Arg Arg Ser Ala Leu Gly Asp Leu Ala Gly Asp Asn Ser 
         195                200                205
Leu Gly Leu Glu Pro Leu Arg Thr Ser Gly Ile Ser Pro Leu Pro Gln 
     210                215                220
Asp Gly Glu Leu Thr Pro Arg Thr Gly Glu Ile Asn Ile Ala Val Thr 
 225                230                235                240
Lys Glu Trp Phe Ile Ile Ala Ser Phe Gly Leu Leu Ser Ala Leu Thr 
                 245                250                255
Leu Cys Tyr Met Ile Ile Arg Ala Thr Ala Ser Leu Asn Ala Asn Glu 
             260                265                270
Val Glu Trp Phe 
         275



<210> 5558
<211> 551
<212> DNA
<213> Rattus norvegicus
<308> AA891810
<400> 5558

aatacaaag  tttggcatt  gcaatttta  gaaaaaata  aatgtacta  aaataaacg  60
ttgtgtggc  tgattggta  atgatgcac  aaaataggt  cttttttcc  tcaaggcaa  120
cagtcagaa  gcagtgttt  ccttcttca  aaccattct  ccttgttac  gcaatgttg  180
tttcacccg  tcgaggagt  agctcccca  cttgaggaa  aggcgatat  ccagaagtt  240
tcagtggct  aaggccaag  gaactgtca  tggcaaggt  accaagggc  gatcttcgg  300
taactgcct  ggttctggt  agcctttcc  tatcaaacg  tacattatc  gtacatggc  360
gatttggca  aattcctag  gctttcaaa  tattaagtt  acacatagg  caggtacag  420
gttcactga  ccagggatc  acacaggat  tgtggaaaa  atgcttgca  gggagaacc  480
gaacaacat  attctgctt  tagctctct  tgcagactg  acagtgatc  aagtctggg  540
ctgtttcct  a  551



<210> 5559
<211> 419
<212> PRT
<213> Rattus norvegicus
<308> NP_067515
<400> 5559

Met Ser Gly Ala Ala Arg Ala Gly Pro Ala Arg Leu Ala Ala Leu Ala 
  1               5                  10                  15
Leu Leu Thr Cys Ser Leu Trp Pro Thr Arg Ala Asp Asn Ala Ser Gln 
             20                  25                  30
Glu Tyr Tyr Thr Ala Leu Ile Asn Val Thr Val Gln Glu Pro Gly Arg 
         35                  40                  45
Gly Thr Pro Leu Thr Phe Arg Ile Asp Arg Gly Arg Tyr Gly Leu Asp 
     50                  55                  60
Ser Pro Lys Ala Glu Val Arg Gly Gln Val Leu Ala Pro Leu Pro Ile 
 65                  70                  75                  80
His Gly Val Ala Asp His Leu Gly Cys Asp Pro Gln Thr Arg Phe Phe 
                 85                  90                  95
Val Pro Pro Asn Ile Lys Gln Trp Ile Ala Leu Leu Gln Arg Gly Asn 
             100                105                110
Cys Thr Phe Lys Glu Lys Ile Ser Arg Ala Ala Phe His Asn Ala Val 
         115                120                125
Ala Val Val Ile Tyr Asn Asn Lys Ser Lys Glu Glu Pro Val Thr Met 
     130                135                140
Thr His Pro Gly Thr Gly Asp Ile Ile Ala Val Met Ile Thr Glu Leu 
 145                150                155                160
Arg Gly Lys Asp Ile Leu Ser Tyr Leu Glu Lys Asn Ile Ser Val Gln 
                 165                170                175
Met Thr Ile Ala Val Gly Thr Arg Met Pro Pro Lys Asn Phe Ser Arg 
             180                185                190
Gly Ser Leu Val Phe Val Ser Ile Ser Phe Ile Val Leu Met Ile Ile 
         195                200                205
Ser Ser Ala Trp Leu Ile Phe Tyr Phe Ile Gln Lys Ile Arg Tyr Thr 
     210                215                220
Asn Ala Arg Asp Arg Asn Gln Arg Arg Leu Gly Asp Ala Ala Lys Lys 
 225                230                235                240
Ala Ile Ser Lys Leu Thr Thr Arg Thr Val Lys Lys Gly Asp Lys Glu 
                 245                250                255
Thr Asp Pro Asp Phe Asp His Cys Ala Val Cys Ile Glu Ser Tyr Lys 
             260                265                270
Gln Asn Asp Val Val Arg Val Leu Pro Cys Lys His Val Phe His Lys 
         275                280                285
Ser Cys Val Asp Pro Trp Leu Ser Glu His Cys Thr Cys Pro Met Cys 
     290                295                300
Lys Leu Asn Ile Leu Arg Ala Leu Gly Ile Val Pro Asn Leu Pro Cys 
 305                310                315                320
Thr Asp Asn Val Ala Phe Asp Met Glu Arg Leu Thr Arg Thr Gln Ala 
                 325                330                335
Val Asn Arg Arg Ala Ala Leu Gly Asp Leu Ala Gly Asp Ser Ser Leu 
             340                345                350
Gly Leu Glu Pro Leu Arg Thr Ser Gly Ile Ser Pro Leu Pro Gln Asp 
         355                360                365
Gly Glu Leu Thr Pro Arg Thr Gly Glu Ile Asn Ile Ala Val Thr Lys 
     370                375                380
Glu Trp Phe Ile Ile Ala Ser Phe Gly Leu Leu Ser Ala Leu Thr Leu 
 385                390                395                400
Cys Tyr Met Ile Ile Arg Ala Thr Ala Ser Leu Asn Ala Asn Glu Val 
                 405                410                415
Glu Trp Phe 
             420



<210> 5560
<211> 1153
<212> DNA
<213> Homo sapiens
<308> AF155650
<400> 5560

ggttcttgt  ctcctaata  caacagtgg  ttgccttgc  gcagagggg  actgcacgt  60
taagagaaa  tatcacggg  cgctttcca  aatgcagtt  ctgtagtca  ctacactaa  120
aaatccaaa  aggagccag  taccatgac  catccaggc  ctggagata  tattgctgt  180
atgataaca  aattgaggg  taaggatat  ttgagttat  tggagaaaa  catctctgt  240
caaatgaca  tagctgttg  aactcgaat  ccaccgaag  acttcagcc  tggctctct  300
gtcttcgtg  caatatcct  tattgtttt  atgattatt  cttcagcat  gctcatatt  360
tacttcatt  agaagatca  gtacacaaa  gcacgcgac  ggaaccagc  tcgtctcgg  420
gatgcagcc  agaaagcca  cagtaaatt  acaaccagg  cagtaaaga  gggtgacaa  480
gaaactgac  cagactttg  tcattgtgc  gtctgcata  agagctata  gcagaatga  540
gtcgtccga  ttctcccct  caagcatgt  ttccacaaa  cctgcgtgg  tccctggct  600
agtgaacat  gtacctgtc  tatgtgcaa  cttaatata  tgaaggccc  gggaattgt  660
ccgaatttg  catgtactg  taacgtagc  ttcgatatg  aaaggctca  cagaaccca  720
gctgttaac  gaagatcag  cctcggcga  ctcgccggc  acaactccc  tggccttga  780
ccacttcga  cttcgggga  ctcacctct  cctcaggat  gggagctca  tccgagaac  840
ggagaaatc  acattgcag  aacaaaaga  tggtttatt  ttgccagtt  tggcctcct  900
agtgccctc  cactctgct  catgatcat  agagccaca  ctagcttga  tgctaatga  960
gtagaatgg  tttgaagaa  aaaaaacct  ctttctgac  gattttgcc  tgaaggaaa  1020
aagaaccta  ttttgtgca  catttacca  tcatgccac  caagcattt  tttttagta  1080
attttattt  ttcataaaa  tgctaatgc  aaagctttg  attaaaaga  ataaataat  1140
aaataaaaa  aaa  1153



<210> 5561
<211> 276
<212> PRT
<213> Homo sapiens
<308> NP_060904
<400> 5561

Met Thr His Pro Gly Thr Gly Asp Ile Ile Ala Val Met Ile Thr Glu 
  1               5                  10                  15
Leu Arg Gly Lys Asp Ile Leu Ser Tyr Leu Glu Lys Asn Ile Ser Val 
             20                  25                  30
Gln Met Thr Ile Ala Val Gly Thr Arg Met Pro Pro Lys Asn Phe Ser 
         35                  40                  45
Arg Gly Ser Leu Val Phe Val Ser Ile Ser Phe Ile Val Leu Met Ile 
     50                  55                  60
Ile Ser Ser Ala Trp Leu Ile Phe Tyr Phe Ile Gln Lys Ile Arg Tyr 
 65                  70                  75                  80
Thr Asn Ala Arg Asp Arg Asn Gln Arg Arg Leu Gly Asp Ala Ala Lys 
                 85                  90                  95
Lys Ala Ile Ser Lys Leu Thr Thr Arg Thr Val Lys Lys Gly Asp Lys 
             100                105                110
Glu Thr Asp Pro Asp Phe Asp His Cys Ala Val Cys Ile Glu Ser Tyr 
         115                120                125
Lys Gln Asn Asp Val Val Arg Ile Leu Pro Cys Lys His Val Phe His 
     130                135                140
Lys Ser Cys Val Asp Pro Trp Leu Ser Glu His Cys Thr Cys Pro Met 
 145                150                155                160
Cys Lys Leu Asn Ile Leu Lys Ala Leu Gly Ile Val Pro Asn Leu Pro 
                 165                170                175
Cys Thr Asp Asn Val Ala Phe Asp Met Glu Arg Leu Thr Arg Thr Gln 
             180                185                190
Ala Val Asn Arg Arg Ser Ala Leu Gly Asp Leu Ala Gly Asp Asn Ser 
         195                200                205
Leu Gly Leu Glu Pro Leu Arg Thr Ser Gly Ile Ser Pro Leu Pro Gln 
     210                215                220
Asp Gly Glu Leu Thr Pro Arg Thr Gly Glu Ile Asn Ile Ala Val Thr 
 225                230                235                240
Lys Glu Trp Phe Ile Ile Ala Ser Phe Gly Leu Leu Ser Ala Leu Thr 
                 245                250                255
Leu Cys Tyr Met Ile Ile Arg Ala Thr Ala Ser Leu Asn Ala Asn Glu 
             260                265                270
Val Glu Trp Phe 
         275



<210> 5562
<211> 551
<212> DNA
<213> Rattus norvegicus
<308> AA891810
<400> 5562

aatacaaag  tttggcatt  gcaatttta  gaaaaaata  aatgtacta  aaataaacg  60
ttgtgtggc  tgattggta  atgatgcac  aaaataggt  cttttttcc  tcaaggcaa  120
cagtcagaa  gcagtgttt  ccttcttca  aaccattct  ccttgttac  gcaatgttg  180
tttcacccg  tcgaggagt  agctcccca  cttgaggaa  aggcgatat  ccagaagtt  240
tcagtggct  aaggccaag  gaactgtca  tggcaaggt  accaagggc  gatcttcgg  300
taactgcct  ggttctggt  agcctttcc  tatcaaacg  tacattatc  gtacatggc  360
gatttggca  aattcctag  gctttcaaa  tattaagtt  acacatagg  caggtacag  420
gttcactga  ccagggatc  acacaggat  tgtggaaaa  atgcttgca  gggagaacc  480
gaacaacat  attctgctt  tagctctct  tgcagactg  acagtgatc  aagtctggg  540
ctgtttcct  a  551



<210> 5563
<211> 419
<212> PRT
<213> Rattus norvegicus
<308> NP_067515
<400> 5563

Met Ser Gly Ala Ala Arg Ala Gly Pro Ala Arg Leu Ala Ala Leu Ala 
  1               5                  10                  15
Leu Leu Thr Cys Ser Leu Trp Pro Thr Arg Ala Asp Asn Ala Ser Gln 
             20                  25                  30
Glu Tyr Tyr Thr Ala Leu Ile Asn Val Thr Val Gln Glu Pro Gly Arg 
         35                  40                  45
Gly Thr Pro Leu Thr Phe Arg Ile Asp Arg Gly Arg Tyr Gly Leu Asp 
     50                  55                  60
Ser Pro Lys Ala Glu Val Arg Gly Gln Val Leu Ala Pro Leu Pro Ile 
 65                  70                  75                  80
His Gly Val Ala Asp His Leu Gly Cys Asp Pro Gln Thr Arg Phe Phe 
                 85                  90                  95
Val Pro Pro Asn Ile Lys Gln Trp Ile Ala Leu Leu Gln Arg Gly Asn 
             100                105                110
Cys Thr Phe Lys Glu Lys Ile Ser Arg Ala Ala Phe His Asn Ala Val 
         115                120                125
Ala Val Val Ile Tyr Asn Asn Lys Ser Lys Glu Glu Pro Val Thr Met 
     130                135                140
Thr His Pro Gly Thr Gly Asp Ile Ile Ala Val Met Ile Thr Glu Leu 
 145                150                155                160
Arg Gly Lys Asp Ile Leu Ser Tyr Leu Glu Lys Asn Ile Ser Val Gln 
                 165                170                175
Met Thr Ile Ala Val Gly Thr Arg Met Pro Pro Lys Asn Phe Ser Arg 
             180                185                190
Gly Ser Leu Val Phe Val Ser Ile Ser Phe Ile Val Leu Met Ile Ile 
         195                200                205
Ser Ser Ala Trp Leu Ile Phe Tyr Phe Ile Gln Lys Ile Arg Tyr Thr 
     210                215                220
Asn Ala Arg Asp Arg Asn Gln Arg Arg Leu Gly Asp Ala Ala Lys Lys 
 225                230                235                240
Ala Ile Ser Lys Leu Thr Thr Arg Thr Val Lys Lys Gly Asp Lys Glu 
                 245                250                255
Thr Asp Pro Asp Phe Asp His Cys Ala Val Cys Ile Glu Ser Tyr Lys 
             260                265                270
Gln Asn Asp Val Val Arg Val Leu Pro Cys Lys His Val Phe His Lys 
         275                280                285
Ser Cys Val Asp Pro Trp Leu Ser Glu His Cys Thr Cys Pro Met Cys 
     290                295                300
Lys Leu Asn Ile Leu Arg Ala Leu Gly Ile Val Pro Asn Leu Pro Cys 
 305                310                315                320
Thr Asp Asn Val Ala Phe Asp Met Glu Arg Leu Thr Arg Thr Gln Ala 
                 325                330                335
Val Asn Arg Arg Ala Ala Leu Gly Asp Leu Ala Gly Asp Ser Ser Leu 
             340                345                350
Gly Leu Glu Pro Leu Arg Thr Ser Gly Ile Ser Pro Leu Pro Gln Asp 
         355                360                365
Gly Glu Leu Thr Pro Arg Thr Gly Glu Ile Asn Ile Ala Val Thr Lys 
     370                375                380
Glu Trp Phe Ile Ile Ala Ser Phe Gly Leu Leu Ser Ala Leu Thr Leu 
 385                390                395                400
Cys Tyr Met Ile Ile Arg Ala Thr Ala Ser Leu Asn Ala Asn Glu Val 
                 405                410                415
Glu Trp Phe 
             420



<210> 5564
<211> 1153
<212> DNA
<213> Homo sapiens
<308> AF155650
<400> 5564

ggttcttgt  ctcctaata  caacagtgg  ttgccttgc  gcagagggg  actgcacgt  60
taagagaaa  tatcacggg  cgctttcca  aatgcagtt  ctgtagtca  ctacactaa  120
aaatccaaa  aggagccag  taccatgac  catccaggc  ctggagata  tattgctgt  180
atgataaca  aattgaggg  taaggatat  ttgagttat  tggagaaaa  catctctgt  240
caaatgaca  tagctgttg  aactcgaat  ccaccgaag  acttcagcc  tggctctct  300
gtcttcgtg  caatatcct  tattgtttt  atgattatt  cttcagcat  gctcatatt  360
tacttcatt  agaagatca  gtacacaaa  gcacgcgac  ggaaccagc  tcgtctcgg  420
gatgcagcc  agaaagcca  cagtaaatt  acaaccagg  cagtaaaga  gggtgacaa  480
gaaactgac  cagactttg  tcattgtgc  gtctgcata  agagctata  gcagaatga  540
gtcgtccga  ttctcccct  caagcatgt  ttccacaaa  cctgcgtgg  tccctggct  600
agtgaacat  gtacctgtc  tatgtgcaa  cttaatata  tgaaggccc  gggaattgt  660
ccgaatttg  catgtactg  taacgtagc  ttcgatatg  aaaggctca  cagaaccca  720
gctgttaac  gaagatcag  cctcggcga  ctcgccggc  acaactccc  tggccttga  780
ccacttcga  cttcgggga  ctcacctct  cctcaggat  gggagctca  tccgagaac  840
ggagaaatc  acattgcag  aacaaaaga  tggtttatt  ttgccagtt  tggcctcct  900
agtgccctc  cactctgct  catgatcat  agagccaca  ctagcttga  tgctaatga  960
gtagaatgg  tttgaagaa  aaaaaacct  ctttctgac  gattttgcc  tgaaggaaa  1020
aagaaccta  ttttgtgca  catttacca  tcatgccac  caagcattt  tttttagta  1080
attttattt  ttcataaaa  tgctaatgc  aaagctttg  attaaaaga  ataaataat  1140
aaataaaaa  aaa  1153



<210> 5565
<211> 276
<212> PRT
<213> Homo sapiens
<308> NP_060904
<400> 5565

Met Thr His Pro Gly Thr Gly Asp Ile Ile Ala Val Met Ile Thr Glu 
  1               5                  10                  15
Leu Arg Gly Lys Asp Ile Leu Ser Tyr Leu Glu Lys Asn Ile Ser Val 
             20                  25                  30
Gln Met Thr Ile Ala Val Gly Thr Arg Met Pro Pro Lys Asn Phe Ser 
         35                  40                  45
Arg Gly Ser Leu Val Phe Val Ser Ile Ser Phe Ile Val Leu Met Ile 
     50                  55                  60
Ile Ser Ser Ala Trp Leu Ile Phe Tyr Phe Ile Gln Lys Ile Arg Tyr 
 65                  70                  75                  80
Thr Asn Ala Arg Asp Arg Asn Gln Arg Arg Leu Gly Asp Ala Ala Lys 
                 85                  90                  95
Lys Ala Ile Ser Lys Leu Thr Thr Arg Thr Val Lys Lys Gly Asp Lys 
             100                105                110
Glu Thr Asp Pro Asp Phe Asp His Cys Ala Val Cys Ile Glu Ser Tyr 
         115                120                125
Lys Gln Asn Asp Val Val Arg Ile Leu Pro Cys Lys His Val Phe His 
     130                135                140
Lys Ser Cys Val Asp Pro Trp Leu Ser Glu His Cys Thr Cys Pro Met 
 145                150                155                160
Cys Lys Leu Asn Ile Leu Lys Ala Leu Gly Ile Val Pro Asn Leu Pro 
                 165                170                175
Cys Thr Asp Asn Val Ala Phe Asp Met Glu Arg Leu Thr Arg Thr Gln 
             180                185                190
Ala Val Asn Arg Arg Ser Ala Leu Gly Asp Leu Ala Gly Asp Asn Ser 
         195                200                205
Leu Gly Leu Glu Pro Leu Arg Thr Ser Gly Ile Ser Pro Leu Pro Gln 
     210                215                220
Asp Gly Glu Leu Thr Pro Arg Thr Gly Glu Ile Asn Ile Ala Val Thr 
 225                230                235                240
Lys Glu Trp Phe Ile Ile Ala Ser Phe Gly Leu Leu Ser Ala Leu Thr 
                 245                250                255
Leu Cys Tyr Met Ile Ile Arg Ala Thr Ala Ser Leu Asn Ala Asn Glu 
             260                265                270
Val Glu Trp Phe 
         275



<210> 5566
<211> 620
<212> DNA
<213> Rattus norvegicus
<308> AA891812
<400> 5566

agacaaaga  actgcttaa  gacttttat  tgtgagtaa  acctgttac  acgaggaaa  60
gacacacag  acctgtcct  caagtctgt  catatatgc  gcgatattc  gtgtgtaat  120
caaagatta  actacaaaa  tgagaagtc  ttgcatatg  gggataaag  aagggccag  180
aggaagacg  ggaggagtc  agatgaggg  actcaggac  aggtgagag  tcaggccac  240
gtggtgact  gtgggacta  cagtacagc  ggctgtggg  tcctgcttg  tgccccatt  300
ggagatcac  gggttctgt  cacatccga  cacccgctc  atgaggccc  acccagcag  360
ggcgtggag  gccccagca  gctccctct  ctagtcagg  tggcagtgg  agctcctgg  420
acaaggccc  ttaggattc  acctgacac  cggcttccc  actcactaa  gcagtttca  480
gcccttttc  agggataaa  gttaggtaa  aattcataa  ggatgacca  gaaggtcat  540
ggctccatg  atgatgcaa  acattagat  gcacctcca  agccagctt  aaccatgag  600
taccatccc  atcaanacca  620



<210> 5567
<211> 3936
<212> DNA
<213> Homo sapiens
<308> X58141
<400> 5567

gggaccggc  ctcagctgg  ggcgcgctc  ccggccgag  tgggatccc  aggcctctc  60
agtccgccg  gggcgcacc  ccggcccgt  tcgcccgcc  cgccgggga  gtggagcac  120
agcgcacgt  ttaggaacc  agaaagatt  tacaatgaa  ggtgattct  gtgctgcgg  180
ggtgacctc  ccacccccg  ccacagccc  tcacaagga  aggtacttc  accgagtag  240
tgagaacaa  ccagagtac  tgagggaga  gaacatggc  ccagacctt  gccaggact  300
caacatgat  gagcaaaag  agagggtgt  catgattct  caaagccct  ctttctgtg  360
agaattgga  tcaatgata  aggagcaat  taagaaggg  aagaacccc  caggcctat  420
ggcattaca  cagattgca  attttatga  cacgaatgt  ccaaatgtc  acccagcag  480
tccgcaagg  gggatggct  ccttaaaca  gagtcttgg  atggtgact  ctgtgaacg  540
tcttagagg  tctgattct  ttgcgtatg  caaaggaga  aagttatta  ggtgtaaat  600
ggcagcgtt  tatagacta  cagatctct  tgggtggtc  cagcttatc  acaatcata  660
cacaaccag  gtgaactcc  agcaggaac  cttcctcat  gtccctttt  ggcttcttt  720
cagtgaagt  actgcatcc  gtttggtta  gatcaatct  caaggagat  tagtagatc  780
tggaagcac  aatctggga  tgaatcagg  cggcttcac  ttacactct  caatttatg  840
tgcacgccc  gacgtgaag  gcgtcgtgc  cattcacac  ccagcaggg  ctgcggtct  900
tgcaatgaa  tgtggcctc  tgccaatct  cccggaggc  ctttccctt  gagaagtgg  960
ttatcatga  taccatggc  ttctggttg  tgaagagga  aaagttttg  ttcagaaaa  1020
tctggggcc  aaaagcaag  ttcttattc  ccggaacca  gggctcgtg  cagttggag  1080
gagcgttga  gaggccttc  attacatcc  taaccttgt  gttgcctgt  agatccagg  1140
tcgaactct  gccagtgca  gaggaccag  caacttagt  ctgctgaat  ctgagaagt  1200
caaagccaa  tcccgttcc  cagggtctc  ggtagggga  ggcactgga  cgcctccca  1260
gtggcagat  ggtgagcag  aatttgaag  cctcatgcg  atgctcgat  atctgggct  1320
cagaactgg  tacccttat  gataccctg  tctgagaga  aagtctaaa  aatacagcg  1380
tgtggaggt  cctgctagt  tcacaggtt  ctcctttgc  agtgacggt  attcgggca  1440
ttgctcccc  ctcagacac  gttttcaga  gcagcagcg  gagaagaca  gatggctga  1500
ctctggccg  ggcgacgaa  cttccgagg  agggcagaa  ggaagcagt  ccaagtcga  1560
gactaagtg  actaaagag  atggacata  aacttccac  tctgctgtc  ctaacctgt  1620
tgttccatt  aacactaac  caaaagagg  ccaggagat  aggaacaag  tccgagagc  1680
gaatttaca  gacattaag  cggctggcc  tcagtccca  gttttgtgt  gtgtagtga  1740
ggacaggag  ctcgtccag  gagagctgg  gacggcctc  aaggccatc  ttgaaaagg  1800
gtaccagcc  cacgtcatt  tgagcacca  gggccccaa  cccttcacc  cactcacag  1860
ccgtgagct  gaggagtac  gcagggagg  ggagaggaa  cagaagggc  gtgaagaga  1920
tctggacga  gctagagaa  agaaagaaa  gagtcctcc  gaccagcct  cggtccccc  1980
cccgcctcc  agcactccc  tcaagctgg  ggaagacct  gtgccggag  cgactactg  2040
agatgacag  gatgctgcc  cctttaagc  aactctccc  gatctgtcc  ctgatgaac  2100
ttcagaagc  ctcggcttc  caatgttag  gaaggagga  gaagcccat  gacccccaa  2160
ccccactga  gcccctact  aggccagcc  cgagccagc  ccagaccca  ccccggtgg  2220
tgaagaggc  gccccctca  ctgtcgagg  gggggccgc  gcggaccct  gcagcgatg  2280
gtctccagg  aagtccccg  ccaaaaaga  gaagaagtt  cgtaccccg  cctttctga  2340
gaagagcaa  aagaagagt  actcctgaa  gccctgcgc  aacactgtc  tgtccggag  2400
gaccctggc  ctgccagcg  ccccggcca  gtctgtgct  tgtccttgt  taatggaat  2460
caaaaaagc  aagccctcc  cctagaggt  ccctcacgt  accagcccc  tgtagcccc  2520
ggctgaccc  gtgtgtgct  agcagcccc  ccccaccct  ccccttgtc  tctcagagc  2580
tcagcttct  ggggagaca  gctctcccc  cagggggga  gcactaagt  atggtcctg  2640
ctggaaggt  ctgaaggct  ctgcagctt  ggctgcacg  caccctcct  agcctcacc  2700
ttcctgccg  ccctcctgt  gtgaaatca  cacattctg  ctctgcttg  cttcccctc  2760
accctaaag  ctcaggtga  ggactcaga  tcctggctt  atgtggcat  ctctctgct  2820
agtgatctc  cttaaatct  tatacaaag  cttggtccc  tgaaaacac  cgtgtgccc  2880
ccagcggcc  tgaagaggc  ggtctgggc  agatgctgg  caggaaacc  cagcggcag  2940
tgggcctgt  tgcacccaa  gtgatgcta  gcatgtctg  ccgacgatc  ctcgaccag  3000
atcagattc  ggagctcag  ttctttttc  cttgggtct  tggattcct  tcataggga  3060
ggtatatca  gaggggaag  ggcctttct  gaattttct  tgagcaggt  tacaattta  3120
cttacattt  tcgactgtg  acgtgaata  gctgctttt  gctttcttc  ttccagacc  3180
cacagtaga  cacttttca  ttatttggg  gaggcttca  gggactgtt  tcaccttaa  3240
tcagccaga  agatgccct  gttgtgatc  aaggtaact  gaggtggag  gtagccctg  3300
ggcccctcg  catcaccgt  attgatgga  cctgaaccg  gtgctcctc  gcagatgct  3360
ttgttgtta  ttccctcca  gaggctgga  aagggctca  agctgctga  caggaaccg  3420
agggtgacc  atttcagga  gtgccggta  cagcctgac  aggtacagg  aagcttgtg  3480
gggcccaac  ggcccttgg  agagctggt  ccagatgtg  gctcagatc  tgggcatga  3540
gggccgagc  acctcggat  ccactgatt  gccagccga  cgagaacca  gctgctgca  3600
ggcactgac  gccgcttcc  gcttcctct  agccgcagg  cctgctacg  gggcaagcg  3660
gctgcctct  ttctgtgtc  ttttgttgc  aaggcagaa  gaaaagtcc  taaccgtgg  3720
ctcttcctt  atcccctcc  ttaccccac  tatgcaatg  cttttaatt  tcacttttg  3780
agtttaatc  tttgtatta  aacatgaaa  atagttgca  atatggaca  cgacttggg  3840
ggacaggtc  tgaatgtcc  ttctccagt  taacatgtt  tactcacaa  taaaattct  3900
tcagcaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaa  3936



<210> 5568
<211> 737
<212> PRT
<213> Homo sapiens
<308> S18207
<400> 5568

Met Asn Gly Asp Ser Arg Ala Ala Val Val Thr Ser Pro Pro Pro Thr 
  1               5                  10                  15
Thr Ala Pro His Lys Glu Arg Tyr Phe Asp Arg Val Asp Glu Asn Asn 
             20                  25                  30
Pro Glu Tyr Leu Arg Glu Arg Asn Met Ala Pro Asp Leu Arg Gln Asp 
         35                  40                  45
Phe Asn Met Met Glu Gln Lys Lys Arg Val Ser Met Ile Leu Gln Ser 
     50                  55                  60
Pro Ala Phe Cys Glu Glu Leu Glu Ser Met Ile Gln Glu Gln Phe Lys 
 65                  70                  75                  80
Lys Gly Lys Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp 
                 85                  90                  95
Phe Met Thr Thr Asn Val Pro Asn Val Tyr Pro Ala Ala Pro Gln Gly 
             100                105                110
Gly Met Ala Ala Leu Asn Met Ser Leu Gly Met Val Thr Pro Val Asn 
         115                120                125
Asp Leu Arg Gly Ser Asp Ser Ile Ala Tyr Asp Lys Gly Glu Lys Leu 
     130                135                140
Leu Arg Cys Lys Leu Ala Ala Phe Tyr Arg Leu Ala Asp Leu Phe Gly 
 145                150                155                160
Trp Ser Gln Leu Ile Tyr Asn His Ile Thr Thr Arg Val Asn Ser Glu 
                 165                170                175
Gln Glu His Phe Leu Ile Val Pro Phe Gly Leu Leu Tyr Ser Glu Val 
             180                185                190
Thr Ala Ser Ser Leu Val Lys Ile Asn Leu Gln Gly Asp Ile Val Asp 
         195                200                205
Arg Gly Ser Thr Asn Leu Gly Val Asn Gln Ala Gly Phe Thr Leu His 
     210                215                220
Ser Ala Ile Tyr Ala Ala Arg Pro Asp Val Lys Cys Val Val His Ile 
 225                230                235                240
His Thr Pro Ala Gly Ala Ala Val Ser Ala Met Lys Cys Gly Leu Leu 
                 245                250                255
Pro Ile Ser Pro Glu Ala Leu Ser Leu Gly Glu Val Ala Tyr His Asp 
             260                265                270
Tyr His Gly Ile Leu Val Asp Glu Glu Glu Lys Val Leu Ile Gln Lys 
         275                280                285
Asn Leu Gly Pro Lys Ser Lys Val Leu Ile Leu Arg Asn His Gly Leu 
     290                295                300
Val Ser Val Gly Glu Ser Val Glu Glu Ala Phe Tyr Tyr Ile His Asn 
 305                310                315                320
Leu Val Val Ala Cys Glu Ile Gln Val Arg Thr Leu Ala Ser Ala Gly 
                 325                330                335
Gly Pro Asp Asn Leu Val Leu Leu Asn Pro Glu Lys Tyr Lys Ala Lys 
             340                345                350
Ser Arg Ser Pro Gly Ser Pro Val Gly Glu Gly Thr Gly Ser Pro Pro 
         355                360                365
Lys Trp Gln Ile Gly Glu Gln Glu Phe Glu Ala Leu Met Arg Met Leu 
     370                375                380
Asp Asn Leu Gly Tyr Arg Thr Gly Tyr Pro Tyr Arg Tyr Pro Ala Leu 
 385                390                395                400
Arg Glu Lys Ser Lys Lys Tyr Ser Asp Val Glu Val Pro Ala Ser Val 
                 405                410                415
Thr Gly Tyr Ser Phe Ala Ser Asp Gly Asp Ser Gly Thr Cys Ser Pro 
             420                425                430
Leu Arg His Ser Phe Gln Lys Gln Gln Arg Glu Lys Thr Arg Trp Leu 
         435                440                445
Asn Ser Gly Arg Gly Asp Glu Ala Ser Glu Glu Gly Gln Asn Gly Ser 
     450                455                460
Ser Pro Lys Ser Lys Thr Lys Trp Thr Lys Glu Asp Gly His Arg Thr 
 465                470                475                480
Ser Thr Ser Ala Val Pro Asn Leu Phe Val Pro Leu Asn Thr Asn Pro 
                 485                490                495
Lys Glu Val Gln Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Leu Gln 
             500                505                510
Asp Ile Lys Thr Ala Gly Pro Gln Ser Gln Val Leu Cys Gly Val Val 
         515                520                525
Met Asp Arg Ser Leu Val Gln Gly Glu Leu Val Thr Ala Ser Lys Ala 
     530                535                540
Ile Ile Glu Lys Glu Tyr Gln Pro His Val Ile Val Ser Thr Thr Gly 
 545                550                555                560
Pro Asn Pro Phe Thr Thr Leu Thr Asp Arg Glu Leu Glu Glu Tyr Arg 
                 565                570                575
Arg Glu Val Glu Arg Lys Gln Lys Gly Ser Glu Glu Asn Leu Asp Glu 
             580                585                590
Ala Arg Glu Gln Lys Glu Lys Ser Pro Pro Asp Gln Pro Ala Val Pro 
         595                600                605
His Pro Pro Pro Ser Thr Pro Ile Lys Leu Glu Glu Asp Leu Val Pro 
     610                615                620
Glu Pro Thr Thr Gly Asp Asp Ser Asp Ala Ala Thr Phe Lys Pro Thr 
 625                630                635                640
Leu Pro Asp Leu Ser Pro Asp Glu Pro Ser Glu Ala Leu Gly Phe Pro 
                 645                650                655
Met Leu Glu Lys Glu Glu Glu Ala His Arg Pro Pro Ser Pro Thr Glu 
             660                665                670
Ala Pro Thr Glu Ala Ser Pro Glu Pro Ala Pro Asp Pro Ala Pro Val 
         675                680                685
Ala Glu Glu Ala Ala Pro Ser Ala Val Glu Glu Gly Ala Ala Ala Asp 
     690                695                700
Pro Gly Ser Asp Gly Ser Pro Gly Lys Ser Pro Ser Lys Lys Lys Lys 
 705                710                715                720
Lys Phe Arg Thr Pro Ser Phe Leu Lys Lys Ser Lys Lys Lys Ser Asp 
                 725                730                735
Ser 
             740



<210> 5569
<211> 620
<212> DNA
<213> Rattus norvegicus
<308> AA891812
<400> 5569

agacaaaga  actgcttaa  gacttttat  tgtgagtaa  acctgttac  acgaggaaa  60
gacacacag  acctgtcct  caagtctgt  catatatgc  gcgatattc  gtgtgtaat  120
caaagatta  actacaaaa  tgagaagtc  ttgcatatg  gggataaag  aagggccag  180
aggaagacg  ggaggagtc  agatgaggg  actcaggac  aggtgagag  tcaggccac  240
gtggtgact  gtgggacta  cagtacagc  ggctgtggg  tcctgcttg  tgccccatt  300
ggagatcac  gggttctgt  cacatccga  cacccgctc  atgaggccc  acccagcag  360
ggcgtggag  gccccagca  gctccctct  ctagtcagg  tggcagtgg  agctcctgg  420
acaaggccc  ttaggattc  acctgacac  cggcttccc  actcactaa  gcagtttca  480
gcccttttc  agggataaa  gttaggtaa  aattcataa  ggatgacca  gaaggtcat  540
ggctccatg  atgatgcaa  acattagat  gcacctcca  agccagctt  aaccatgag  600
taccatccc  atcaanacca  620



<210> 5570
<211> 3936
<212> DNA
<213> Homo sapiens
<308> X58141
<400> 5570

gggaccggc  ctcagctgg  ggcgcgctc  ccggccgag  tgggatccc  aggcctctc  60
agtccgccg  gggcgcacc  ccggcccgt  tcgcccgcc  cgccgggga  gtggagcac  120
agcgcacgt  ttaggaacc  agaaagatt  tacaatgaa  ggtgattct  gtgctgcgg  180
ggtgacctc  ccacccccg  ccacagccc  tcacaagga  aggtacttc  accgagtag  240
tgagaacaa  ccagagtac  tgagggaga  gaacatggc  ccagacctt  gccaggact  300
caacatgat  gagcaaaag  agagggtgt  catgattct  caaagccct  ctttctgtg  360
agaattgga  tcaatgata  aggagcaat  taagaaggg  aagaacccc  caggcctat  420
ggcattaca  cagattgca  attttatga  cacgaatgt  ccaaatgtc  acccagcag  480
tccgcaagg  gggatggct  ccttaaaca  gagtcttgg  atggtgact  ctgtgaacg  540
tcttagagg  tctgattct  ttgcgtatg  caaaggaga  aagttatta  ggtgtaaat  600
ggcagcgtt  tatagacta  cagatctct  tgggtggtc  cagcttatc  acaatcata  660
cacaaccag  gtgaactcc  agcaggaac  cttcctcat  gtccctttt  ggcttcttt  720
cagtgaagt  actgcatcc  gtttggtta  gatcaatct  caaggagat  tagtagatc  780
tggaagcac  aatctggga  tgaatcagg  cggcttcac  ttacactct  caatttatg  840
tgcacgccc  gacgtgaag  gcgtcgtgc  cattcacac  ccagcaggg  ctgcggtct  900
tgcaatgaa  tgtggcctc  tgccaatct  cccggaggc  ctttccctt  gagaagtgg  960
ttatcatga  taccatggc  ttctggttg  tgaagagga  aaagttttg  ttcagaaaa  1020
tctggggcc  aaaagcaag  ttcttattc  ccggaacca  gggctcgtg  cagttggag  1080
gagcgttga  gaggccttc  attacatcc  taaccttgt  gttgcctgt  agatccagg  1140
tcgaactct  gccagtgca  gaggaccag  caacttagt  ctgctgaat  ctgagaagt  1200
caaagccaa  tcccgttcc  cagggtctc  ggtagggga  ggcactgga  cgcctccca  1260
gtggcagat  ggtgagcag  aatttgaag  cctcatgcg  atgctcgat  atctgggct  1320
cagaactgg  tacccttat  gataccctg  tctgagaga  aagtctaaa  aatacagcg  1380
tgtggaggt  cctgctagt  tcacaggtt  ctcctttgc  agtgacggt  attcgggca  1440
ttgctcccc  ctcagacac  gttttcaga  gcagcagcg  gagaagaca  gatggctga  1500
ctctggccg  ggcgacgaa  cttccgagg  agggcagaa  ggaagcagt  ccaagtcga  1560
gactaagtg  actaaagag  atggacata  aacttccac  tctgctgtc  ctaacctgt  1620
tgttccatt  aacactaac  caaaagagg  ccaggagat  aggaacaag  tccgagagc  1680
gaatttaca  gacattaag  cggctggcc  tcagtccca  gttttgtgt  gtgtagtga  1740
ggacaggag  ctcgtccag  gagagctgg  gacggcctc  aaggccatc  ttgaaaagg  1800
gtaccagcc  cacgtcatt  tgagcacca  gggccccaa  cccttcacc  cactcacag  1860
ccgtgagct  gaggagtac  gcagggagg  ggagaggaa  cagaagggc  gtgaagaga  1920
tctggacga  gctagagaa  agaaagaaa  gagtcctcc  gaccagcct  cggtccccc  1980
cccgcctcc  agcactccc  tcaagctgg  ggaagacct  gtgccggag  cgactactg  2040
agatgacag  gatgctgcc  cctttaagc  aactctccc  gatctgtcc  ctgatgaac  2100
ttcagaagc  ctcggcttc  caatgttag  gaaggagga  gaagcccat  gacccccaa  2160
ccccactga  gcccctact  aggccagcc  cgagccagc  ccagaccca  ccccggtgg  2220
tgaagaggc  gccccctca  ctgtcgagg  gggggccgc  gcggaccct  gcagcgatg  2280
gtctccagg  aagtccccg  ccaaaaaga  gaagaagtt  cgtaccccg  cctttctga  2340
gaagagcaa  aagaagagt  actcctgaa  gccctgcgc  aacactgtc  tgtccggag  2400
gaccctggc  ctgccagcg  ccccggcca  gtctgtgct  tgtccttgt  taatggaat  2460
caaaaaagc  aagccctcc  cctagaggt  ccctcacgt  accagcccc  tgtagcccc  2520
ggctgaccc  gtgtgtgct  agcagcccc  ccccaccct  ccccttgtc  tctcagagc  2580
tcagcttct  ggggagaca  gctctcccc  cagggggga  gcactaagt  atggtcctg  2640
ctggaaggt  ctgaaggct  ctgcagctt  ggctgcacg  caccctcct  agcctcacc  2700
ttcctgccg  ccctcctgt  gtgaaatca  cacattctg  ctctgcttg  cttcccctc  2760
accctaaag  ctcaggtga  ggactcaga  tcctggctt  atgtggcat  ctctctgct  2820
agtgatctc  cttaaatct  tatacaaag  cttggtccc  tgaaaacac  cgtgtgccc  2880
ccagcggcc  tgaagaggc  ggtctgggc  agatgctgg  caggaaacc  cagcggcag  2940
tgggcctgt  tgcacccaa  gtgatgcta  gcatgtctg  ccgacgatc  ctcgaccag  3000
atcagattc  ggagctcag  ttctttttc  cttgggtct  tggattcct  tcataggga  3060
ggtatatca  gaggggaag  ggcctttct  gaattttct  tgagcaggt  tacaattta  3120
cttacattt  tcgactgtg  acgtgaata  gctgctttt  gctttcttc  ttccagacc  3180
cacagtaga  cacttttca  ttatttggg  gaggcttca  gggactgtt  tcaccttaa  3240
tcagccaga  agatgccct  gttgtgatc  aaggtaact  gaggtggag  gtagccctg  3300
ggcccctcg  catcaccgt  attgatgga  cctgaaccg  gtgctcctc  gcagatgct  3360
ttgttgtta  ttccctcca  gaggctgga  aagggctca  agctgctga  caggaaccg  3420
agggtgacc  atttcagga  gtgccggta  cagcctgac  aggtacagg  aagcttgtg  3480
gggcccaac  ggcccttgg  agagctggt  ccagatgtg  gctcagatc  tgggcatga  3540
gggccgagc  acctcggat  ccactgatt  gccagccga  cgagaacca  gctgctgca  3600
ggcactgac  gccgcttcc  gcttcctct  agccgcagg  cctgctacg  gggcaagcg  3660
gctgcctct  ttctgtgtc  ttttgttgc  aaggcagaa  gaaaagtcc  taaccgtgg  3720
ctcttcctt  atcccctcc  ttaccccac  tatgcaatg  cttttaatt  tcacttttg  3780
agtttaatc  tttgtatta  aacatgaaa  atagttgca  atatggaca  cgacttggg  3840
ggacaggtc  tgaatgtcc  ttctccagt  taacatgtt  tactcacaa  taaaattct  3900
tcagcaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaa  3936



<210> 5571
<211> 737
<212> PRT
<213> Homo sapiens
<308> S18207
<400> 5571

Met Asn Gly Asp Ser Arg Ala Ala Val Val Thr Ser Pro Pro Pro Thr 
  1               5                  10                  15
Thr Ala Pro His Lys Glu Arg Tyr Phe Asp Arg Val Asp Glu Asn Asn 
             20                  25                  30
Pro Glu Tyr Leu Arg Glu Arg Asn Met Ala Pro Asp Leu Arg Gln Asp 
         35                  40                  45
Phe Asn Met Met Glu Gln Lys Lys Arg Val Ser Met Ile Leu Gln Ser 
     50                  55                  60
Pro Ala Phe Cys Glu Glu Leu Glu Ser Met Ile Gln Glu Gln Phe Lys 
 65                  70                  75                  80
Lys Gly Lys Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp 
                 85                  90                  95
Phe Met Thr Thr Asn Val Pro Asn Val Tyr Pro Ala Ala Pro Gln Gly 
             100                105                110
Gly Met Ala Ala Leu Asn Met Ser Leu Gly Met Val Thr Pro Val Asn 
         115                120                125
Asp Leu Arg Gly Ser Asp Ser Ile Ala Tyr Asp Lys Gly Glu Lys Leu 
     130                135                140
Leu Arg Cys Lys Leu Ala Ala Phe Tyr Arg Leu Ala Asp Leu Phe Gly 
 145                150                155                160
Trp Ser Gln Leu Ile Tyr Asn His Ile Thr Thr Arg Val Asn Ser Glu 
                 165                170                175
Gln Glu His Phe Leu Ile Val Pro Phe Gly Leu Leu Tyr Ser Glu Val 
             180                185                190
Thr Ala Ser Ser Leu Val Lys Ile Asn Leu Gln Gly Asp Ile Val Asp 
         195                200                205
Arg Gly Ser Thr Asn Leu Gly Val Asn Gln Ala Gly Phe Thr Leu His 
     210                215                220
Ser Ala Ile Tyr Ala Ala Arg Pro Asp Val Lys Cys Val Val His Ile 
 225                230                235                240
His Thr Pro Ala Gly Ala Ala Val Ser Ala Met Lys Cys Gly Leu Leu 
                 245                250                255
Pro Ile Ser Pro Glu Ala Leu Ser Leu Gly Glu Val Ala Tyr His Asp 
             260                265                270
Tyr His Gly Ile Leu Val Asp Glu Glu Glu Lys Val Leu Ile Gln Lys 
         275                280                285
Asn Leu Gly Pro Lys Ser Lys Val Leu Ile Leu Arg Asn His Gly Leu 
     290                295                300
Val Ser Val Gly Glu Ser Val Glu Glu Ala Phe Tyr Tyr Ile His Asn 
 305                310                315                320
Leu Val Val Ala Cys Glu Ile Gln Val Arg Thr Leu Ala Ser Ala Gly 
                 325                330                335
Gly Pro Asp Asn Leu Val Leu Leu Asn Pro Glu Lys Tyr Lys Ala Lys 
             340                345                350
Ser Arg Ser Pro Gly Ser Pro Val Gly Glu Gly Thr Gly Ser Pro Pro 
         355                360                365
Lys Trp Gln Ile Gly Glu Gln Glu Phe Glu Ala Leu Met Arg Met Leu 
     370                375                380
Asp Asn Leu Gly Tyr Arg Thr Gly Tyr Pro Tyr Arg Tyr Pro Ala Leu 
 385                390                395                400
Arg Glu Lys Ser Lys Lys Tyr Ser Asp Val Glu Val Pro Ala Ser Val 
                 405                410                415
Thr Gly Tyr Ser Phe Ala Ser Asp Gly Asp Ser Gly Thr Cys Ser Pro 
             420                425                430
Leu Arg His Ser Phe Gln Lys Gln Gln Arg Glu Lys Thr Arg Trp Leu 
         435                440                445
Asn Ser Gly Arg Gly Asp Glu Ala Ser Glu Glu Gly Gln Asn Gly Ser 
     450                455                460
Ser Pro Lys Ser Lys Thr Lys Trp Thr Lys Glu Asp Gly His Arg Thr 
 465                470                475                480
Ser Thr Ser Ala Val Pro Asn Leu Phe Val Pro Leu Asn Thr Asn Pro 
                 485                490                495
Lys Glu Val Gln Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Leu Gln 
             500                505                510
Asp Ile Lys Thr Ala Gly Pro Gln Ser Gln Val Leu Cys Gly Val Val 
         515                520                525
Met Asp Arg Ser Leu Val Gln Gly Glu Leu Val Thr Ala Ser Lys Ala 
     530                535                540
Ile Ile Glu Lys Glu Tyr Gln Pro His Val Ile Val Ser Thr Thr Gly 
 545                550                555                560
Pro Asn Pro Phe Thr Thr Leu Thr Asp Arg Glu Leu Glu Glu Tyr Arg 
                 565                570                575
Arg Glu Val Glu Arg Lys Gln Lys Gly Ser Glu Glu Asn Leu Asp Glu 
             580                585                590
Ala Arg Glu Gln Lys Glu Lys Ser Pro Pro Asp Gln Pro Ala Val Pro 
         595                600                605
His Pro Pro Pro Ser Thr Pro Ile Lys Leu Glu Glu Asp Leu Val Pro 
     610                615                620
Glu Pro Thr Thr Gly Asp Asp Ser Asp Ala Ala Thr Phe Lys Pro Thr 
 625                630                635                640
Leu Pro Asp Leu Ser Pro Asp Glu Pro Ser Glu Ala Leu Gly Phe Pro 
                 645                650                655
Met Leu Glu Lys Glu Glu Glu Ala His Arg Pro Pro Ser Pro Thr Glu 
             660                665                670
Ala Pro Thr Glu Ala Ser Pro Glu Pro Ala Pro Asp Pro Ala Pro Val 
         675                680                685
Ala Glu Glu Ala Ala Pro Ser Ala Val Glu Glu Gly Ala Ala Ala Asp 
     690                695                700
Pro Gly Ser Asp Gly Ser Pro Gly Lys Ser Pro Ser Lys Lys Lys Lys 
 705                710                715                720
Lys Phe Arg Thr Pro Ser Phe Leu Lys Lys Ser Lys Lys Lys Ser Asp 
                 725                730                735
Ser 
             740



<210> 5572
<211> 620
<212> DNA
<213> Rattus norvegicus
<308> AA891812
<400> 5572

agacaaaga  actgcttaa  gacttttat  tgtgagtaa  acctgttac  acgaggaaa  60
gacacacag  acctgtcct  caagtctgt  catatatgc  gcgatattc  gtgtgtaat  120
caaagatta  actacaaaa  tgagaagtc  ttgcatatg  gggataaag  aagggccag  180
aggaagacg  ggaggagtc  agatgaggg  actcaggac  aggtgagag  tcaggccac  240
gtggtgact  gtgggacta  cagtacagc  ggctgtggg  tcctgcttg  tgccccatt  300
ggagatcac  gggttctgt  cacatccga  cacccgctc  atgaggccc  acccagcag  360
ggcgtggag  gccccagca  gctccctct  ctagtcagg  tggcagtgg  agctcctgg  420
acaaggccc  ttaggattc  acctgacac  cggcttccc  actcactaa  gcagtttca  480
gcccttttc  agggataaa  gttaggtaa  aattcataa  ggatgacca  gaaggtcat  540
ggctccatg  atgatgcaa  acattagat  gcacctcca  agccagctt  aaccatgag  600
taccatccc  atcaanacca  620



<210> 5573
<211> 3936
<212> DNA
<213> Homo sapiens
<308> X58141
<400> 5573

gggaccggc  ctcagctgg  ggcgcgctc  ccggccgag  tgggatccc  aggcctctc  60
agtccgccg  gggcgcacc  ccggcccgt  tcgcccgcc  cgccgggga  gtggagcac  120
agcgcacgt  ttaggaacc  agaaagatt  tacaatgaa  ggtgattct  gtgctgcgg  180
ggtgacctc  ccacccccg  ccacagccc  tcacaagga  aggtacttc  accgagtag  240
tgagaacaa  ccagagtac  tgagggaga  gaacatggc  ccagacctt  gccaggact  300
caacatgat  gagcaaaag  agagggtgt  catgattct  caaagccct  ctttctgtg  360
agaattgga  tcaatgata  aggagcaat  taagaaggg  aagaacccc  caggcctat  420
ggcattaca  cagattgca  attttatga  cacgaatgt  ccaaatgtc  acccagcag  480
tccgcaagg  gggatggct  ccttaaaca  gagtcttgg  atggtgact  ctgtgaacg  540
tcttagagg  tctgattct  ttgcgtatg  caaaggaga  aagttatta  ggtgtaaat  600
ggcagcgtt  tatagacta  cagatctct  tgggtggtc  cagcttatc  acaatcata  660
cacaaccag  gtgaactcc  agcaggaac  cttcctcat  gtccctttt  ggcttcttt  720
cagtgaagt  actgcatcc  gtttggtta  gatcaatct  caaggagat  tagtagatc  780
tggaagcac  aatctggga  tgaatcagg  cggcttcac  ttacactct  caatttatg  840
tgcacgccc  gacgtgaag  gcgtcgtgc  cattcacac  ccagcaggg  ctgcggtct  900
tgcaatgaa  tgtggcctc  tgccaatct  cccggaggc  ctttccctt  gagaagtgg  960
ttatcatga  taccatggc  ttctggttg  tgaagagga  aaagttttg  ttcagaaaa  1020
tctggggcc  aaaagcaag  ttcttattc  ccggaacca  gggctcgtg  cagttggag  1080
gagcgttga  gaggccttc  attacatcc  taaccttgt  gttgcctgt  agatccagg  1140
tcgaactct  gccagtgca  gaggaccag  caacttagt  ctgctgaat  ctgagaagt  1200
caaagccaa  tcccgttcc  cagggtctc  ggtagggga  ggcactgga  cgcctccca  1260
gtggcagat  ggtgagcag  aatttgaag  cctcatgcg  atgctcgat  atctgggct  1320
cagaactgg  tacccttat  gataccctg  tctgagaga  aagtctaaa  aatacagcg  1380
tgtggaggt  cctgctagt  tcacaggtt  ctcctttgc  agtgacggt  attcgggca  1440
ttgctcccc  ctcagacac  gttttcaga  gcagcagcg  gagaagaca  gatggctga  1500
ctctggccg  ggcgacgaa  cttccgagg  agggcagaa  ggaagcagt  ccaagtcga  1560
gactaagtg  actaaagag  atggacata  aacttccac  tctgctgtc  ctaacctgt  1620
tgttccatt  aacactaac  caaaagagg  ccaggagat  aggaacaag  tccgagagc  1680
gaatttaca  gacattaag  cggctggcc  tcagtccca  gttttgtgt  gtgtagtga  1740
ggacaggag  ctcgtccag  gagagctgg  gacggcctc  aaggccatc  ttgaaaagg  1800
gtaccagcc  cacgtcatt  tgagcacca  gggccccaa  cccttcacc  cactcacag  1860
ccgtgagct  gaggagtac  gcagggagg  ggagaggaa  cagaagggc  gtgaagaga  1920
tctggacga  gctagagaa  agaaagaaa  gagtcctcc  gaccagcct  cggtccccc  1980
cccgcctcc  agcactccc  tcaagctgg  ggaagacct  gtgccggag  cgactactg  2040
agatgacag  gatgctgcc  cctttaagc  aactctccc  gatctgtcc  ctgatgaac  2100
ttcagaagc  ctcggcttc  caatgttag  gaaggagga  gaagcccat  gacccccaa  2160
ccccactga  gcccctact  aggccagcc  cgagccagc  ccagaccca  ccccggtgg  2220
tgaagaggc  gccccctca  ctgtcgagg  gggggccgc  gcggaccct  gcagcgatg  2280
gtctccagg  aagtccccg  ccaaaaaga  gaagaagtt  cgtaccccg  cctttctga  2340
gaagagcaa  aagaagagt  actcctgaa  gccctgcgc  aacactgtc  tgtccggag  2400
gaccctggc  ctgccagcg  ccccggcca  gtctgtgct  tgtccttgt  taatggaat  2460
caaaaaagc  aagccctcc  cctagaggt  ccctcacgt  accagcccc  tgtagcccc  2520
ggctgaccc  gtgtgtgct  agcagcccc  ccccaccct  ccccttgtc  tctcagagc  2580
tcagcttct  ggggagaca  gctctcccc  cagggggga  gcactaagt  atggtcctg  2640
ctggaaggt  ctgaaggct  ctgcagctt  ggctgcacg  caccctcct  agcctcacc  2700
ttcctgccg  ccctcctgt  gtgaaatca  cacattctg  ctctgcttg  cttcccctc  2760
accctaaag  ctcaggtga  ggactcaga  tcctggctt  atgtggcat  ctctctgct  2820
agtgatctc  cttaaatct  tatacaaag  cttggtccc  tgaaaacac  cgtgtgccc  2880
ccagcggcc  tgaagaggc  ggtctgggc  agatgctgg  caggaaacc  cagcggcag  2940
tgggcctgt  tgcacccaa  gtgatgcta  gcatgtctg  ccgacgatc  ctcgaccag  3000
atcagattc  ggagctcag  ttctttttc  cttgggtct  tggattcct  tcataggga  3060
ggtatatca  gaggggaag  ggcctttct  gaattttct  tgagcaggt  tacaattta  3120
cttacattt  tcgactgtg  acgtgaata  gctgctttt  gctttcttc  ttccagacc  3180
cacagtaga  cacttttca  ttatttggg  gaggcttca  gggactgtt  tcaccttaa  3240
tcagccaga  agatgccct  gttgtgatc  aaggtaact  gaggtggag  gtagccctg  3300
ggcccctcg  catcaccgt  attgatgga  cctgaaccg  gtgctcctc  gcagatgct  3360
ttgttgtta  ttccctcca  gaggctgga  aagggctca  agctgctga  caggaaccg  3420
agggtgacc  atttcagga  gtgccggta  cagcctgac  aggtacagg  aagcttgtg  3480
gggcccaac  ggcccttgg  agagctggt  ccagatgtg  gctcagatc  tgggcatga  3540
gggccgagc  acctcggat  ccactgatt  gccagccga  cgagaacca  gctgctgca  3600
ggcactgac  gccgcttcc  gcttcctct  agccgcagg  cctgctacg  gggcaagcg  3660
gctgcctct  ttctgtgtc  ttttgttgc  aaggcagaa  gaaaagtcc  taaccgtgg  3720
ctcttcctt  atcccctcc  ttaccccac  tatgcaatg  cttttaatt  tcacttttg  3780
agtttaatc  tttgtatta  aacatgaaa  atagttgca  atatggaca  cgacttggg  3840
ggacaggtc  tgaatgtcc  ttctccagt  taacatgtt  tactcacaa  taaaattct  3900
tcagcaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaa  3936



<210> 5574
<211> 737
<212> PRT
<213> Homo sapiens
<308> S18207
<400> 5574

Met Asn Gly Asp Ser Arg Ala Ala Val Val Thr Ser Pro Pro Pro Thr 
  1               5                  10                  15
Thr Ala Pro His Lys Glu Arg Tyr Phe Asp Arg Val Asp Glu Asn Asn 
             20                  25                  30
Pro Glu Tyr Leu Arg Glu Arg Asn Met Ala Pro Asp Leu Arg Gln Asp 
         35                  40                  45
Phe Asn Met Met Glu Gln Lys Lys Arg Val Ser Met Ile Leu Gln Ser 
     50                  55                  60
Pro Ala Phe Cys Glu Glu Leu Glu Ser Met Ile Gln Glu Gln Phe Lys 
 65                  70                  75                  80
Lys Gly Lys Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp 
                 85                  90                  95
Phe Met Thr Thr Asn Val Pro Asn Val Tyr Pro Ala Ala Pro Gln Gly 
             100                105                110
Gly Met Ala Ala Leu Asn Met Ser Leu Gly Met Val Thr Pro Val Asn 
         115                120                125
Asp Leu Arg Gly Ser Asp Ser Ile Ala Tyr Asp Lys Gly Glu Lys Leu 
     130                135                140
Leu Arg Cys Lys Leu Ala Ala Phe Tyr Arg Leu Ala Asp Leu Phe Gly 
 145                150                155                160
Trp Ser Gln Leu Ile Tyr Asn His Ile Thr Thr Arg Val Asn Ser Glu 
                 165                170                175
Gln Glu His Phe Leu Ile Val Pro Phe Gly Leu Leu Tyr Ser Glu Val 
             180                185                190
Thr Ala Ser Ser Leu Val Lys Ile Asn Leu Gln Gly Asp Ile Val Asp 
         195                200                205
Arg Gly Ser Thr Asn Leu Gly Val Asn Gln Ala Gly Phe Thr Leu His 
     210                215                220
Ser Ala Ile Tyr Ala Ala Arg Pro Asp Val Lys Cys Val Val His Ile 
 225                230                235                240
His Thr Pro Ala Gly Ala Ala Val Ser Ala Met Lys Cys Gly Leu Leu 
                 245                250                255
Pro Ile Ser Pro Glu Ala Leu Ser Leu Gly Glu Val Ala Tyr His Asp 
             260                265                270
Tyr His Gly Ile Leu Val Asp Glu Glu Glu Lys Val Leu Ile Gln Lys 
         275                280                285
Asn Leu Gly Pro Lys Ser Lys Val Leu Ile Leu Arg Asn His Gly Leu 
     290                295                300
Val Ser Val Gly Glu Ser Val Glu Glu Ala Phe Tyr Tyr Ile His Asn 
 305                310                315                320
Leu Val Val Ala Cys Glu Ile Gln Val Arg Thr Leu Ala Ser Ala Gly 
                 325                330                335
Gly Pro Asp Asn Leu Val Leu Leu Asn Pro Glu Lys Tyr Lys Ala Lys 
             340                345                350
Ser Arg Ser Pro Gly Ser Pro Val Gly Glu Gly Thr Gly Ser Pro Pro 
         355                360                365
Lys Trp Gln Ile Gly Glu Gln Glu Phe Glu Ala Leu Met Arg Met Leu 
     370                375                380
Asp Asn Leu Gly Tyr Arg Thr Gly Tyr Pro Tyr Arg Tyr Pro Ala Leu 
 385                390                395                400
Arg Glu Lys Ser Lys Lys Tyr Ser Asp Val Glu Val Pro Ala Ser Val 
                 405                410                415
Thr Gly Tyr Ser Phe Ala Ser Asp Gly Asp Ser Gly Thr Cys Ser Pro 
             420                425                430
Leu Arg His Ser Phe Gln Lys Gln Gln Arg Glu Lys Thr Arg Trp Leu 
         435                440                445
Asn Ser Gly Arg Gly Asp Glu Ala Ser Glu Glu Gly Gln Asn Gly Ser 
     450                455                460
Ser Pro Lys Ser Lys Thr Lys Trp Thr Lys Glu Asp Gly His Arg Thr 
 465                470                475                480
Ser Thr Ser Ala Val Pro Asn Leu Phe Val Pro Leu Asn Thr Asn Pro 
                 485                490                495
Lys Glu Val Gln Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Leu Gln 
             500                505                510
Asp Ile Lys Thr Ala Gly Pro Gln Ser Gln Val Leu Cys Gly Val Val 
         515                520                525
Met Asp Arg Ser Leu Val Gln Gly Glu Leu Val Thr Ala Ser Lys Ala 
     530                535                540
Ile Ile Glu Lys Glu Tyr Gln Pro His Val Ile Val Ser Thr Thr Gly 
 545                550                555                560
Pro Asn Pro Phe Thr Thr Leu Thr Asp Arg Glu Leu Glu Glu Tyr Arg 
                 565                570                575
Arg Glu Val Glu Arg Lys Gln Lys Gly Ser Glu Glu Asn Leu Asp Glu 
             580                585                590
Ala Arg Glu Gln Lys Glu Lys Ser Pro Pro Asp Gln Pro Ala Val Pro 
         595                600                605
His Pro Pro Pro Ser Thr Pro Ile Lys Leu Glu Glu Asp Leu Val Pro 
     610                615                620
Glu Pro Thr Thr Gly Asp Asp Ser Asp Ala Ala Thr Phe Lys Pro Thr 
 625                630                635                640
Leu Pro Asp Leu Ser Pro Asp Glu Pro Ser Glu Ala Leu Gly Phe Pro 
                 645                650                655
Met Leu Glu Lys Glu Glu Glu Ala His Arg Pro Pro Ser Pro Thr Glu 
             660                665                670
Ala Pro Thr Glu Ala Ser Pro Glu Pro Ala Pro Asp Pro Ala Pro Val 
         675                680                685
Ala Glu Glu Ala Ala Pro Ser Ala Val Glu Glu Gly Ala Ala Ala Asp 
     690                695                700
Pro Gly Ser Asp Gly Ser Pro Gly Lys Ser Pro Ser Lys Lys Lys Lys 
 705                710                715                720
Lys Phe Arg Thr Pro Ser Phe Leu Lys Lys Ser Lys Lys Lys Ser Asp 
                 725                730                735
Ser 
             740



<210> 5575
<211> 620
<212> DNA
<213> Rattus norvegicus
<308> AA891812
<400> 5575

agacaaaga  actgcttaa  gacttttat  tgtgagtaa  acctgttac  acgaggaaa  60
gacacacag  acctgtcct  caagtctgt  catatatgc  gcgatattc  gtgtgtaat  120
caaagatta  actacaaaa  tgagaagtc  ttgcatatg  gggataaag  aagggccag  180
aggaagacg  ggaggagtc  agatgaggg  actcaggac  aggtgagag  tcaggccac  240
gtggtgact  gtgggacta  cagtacagc  ggctgtggg  tcctgcttg  tgccccatt  300
ggagatcac  gggttctgt  cacatccga  cacccgctc  atgaggccc  acccagcag  360
ggcgtggag  gccccagca  gctccctct  ctagtcagg  tggcagtgg  agctcctgg  420
acaaggccc  ttaggattc  acctgacac  cggcttccc  actcactaa  gcagtttca  480
gcccttttc  agggataaa  gttaggtaa  aattcataa  ggatgacca  gaaggtcat  540
ggctccatg  atgatgcaa  acattagat  gcacctcca  agccagctt  aaccatgag  600
taccatccc  atcaanacca  620



<210> 5576
<211> 3936
<212> DNA
<213> Homo sapiens
<308> X58141
<400> 5576

gggaccggc  ctcagctgg  ggcgcgctc  ccggccgag  tgggatccc  aggcctctc  60
agtccgccg  gggcgcacc  ccggcccgt  tcgcccgcc  cgccgggga  gtggagcac  120
agcgcacgt  ttaggaacc  agaaagatt  tacaatgaa  ggtgattct  gtgctgcgg  180
ggtgacctc  ccacccccg  ccacagccc  tcacaagga  aggtacttc  accgagtag  240
tgagaacaa  ccagagtac  tgagggaga  gaacatggc  ccagacctt  gccaggact  300
caacatgat  gagcaaaag  agagggtgt  catgattct  caaagccct  ctttctgtg  360
agaattgga  tcaatgata  aggagcaat  taagaaggg  aagaacccc  caggcctat  420
ggcattaca  cagattgca  attttatga  cacgaatgt  ccaaatgtc  acccagcag  480
tccgcaagg  gggatggct  ccttaaaca  gagtcttgg  atggtgact  ctgtgaacg  540
tcttagagg  tctgattct  ttgcgtatg  caaaggaga  aagttatta  ggtgtaaat  600
ggcagcgtt  tatagacta  cagatctct  tgggtggtc  cagcttatc  acaatcata  660
cacaaccag  gtgaactcc  agcaggaac  cttcctcat  gtccctttt  ggcttcttt  720
cagtgaagt  actgcatcc  gtttggtta  gatcaatct  caaggagat  tagtagatc  780
tggaagcac  aatctggga  tgaatcagg  cggcttcac  ttacactct  caatttatg  840
tgcacgccc  gacgtgaag  gcgtcgtgc  cattcacac  ccagcaggg  ctgcggtct  900
tgcaatgaa  tgtggcctc  tgccaatct  cccggaggc  ctttccctt  gagaagtgg  960
ttatcatga  taccatggc  ttctggttg  tgaagagga  aaagttttg  ttcagaaaa  1020
tctggggcc  aaaagcaag  ttcttattc  ccggaacca  gggctcgtg  cagttggag  1080
gagcgttga  gaggccttc  attacatcc  taaccttgt  gttgcctgt  agatccagg  1140
tcgaactct  gccagtgca  gaggaccag  caacttagt  ctgctgaat  ctgagaagt  1200
caaagccaa  tcccgttcc  cagggtctc  ggtagggga  ggcactgga  cgcctccca  1260
gtggcagat  ggtgagcag  aatttgaag  cctcatgcg  atgctcgat  atctgggct  1320
cagaactgg  tacccttat  gataccctg  tctgagaga  aagtctaaa  aatacagcg  1380
tgtggaggt  cctgctagt  tcacaggtt  ctcctttgc  agtgacggt  attcgggca  1440
ttgctcccc  ctcagacac  gttttcaga  gcagcagcg  gagaagaca  gatggctga  1500
ctctggccg  ggcgacgaa  cttccgagg  agggcagaa  ggaagcagt  ccaagtcga  1560
gactaagtg  actaaagag  atggacata  aacttccac  tctgctgtc  ctaacctgt  1620
tgttccatt  aacactaac  caaaagagg  ccaggagat  aggaacaag  tccgagagc  1680
gaatttaca  gacattaag  cggctggcc  tcagtccca  gttttgtgt  gtgtagtga  1740
ggacaggag  ctcgtccag  gagagctgg  gacggcctc  aaggccatc  ttgaaaagg  1800
gtaccagcc  cacgtcatt  tgagcacca  gggccccaa  cccttcacc  cactcacag  1860
ccgtgagct  gaggagtac  gcagggagg  ggagaggaa  cagaagggc  gtgaagaga  1920
tctggacga  gctagagaa  agaaagaaa  gagtcctcc  gaccagcct  cggtccccc  1980
cccgcctcc  agcactccc  tcaagctgg  ggaagacct  gtgccggag  cgactactg  2040
agatgacag  gatgctgcc  cctttaagc  aactctccc  gatctgtcc  ctgatgaac  2100
ttcagaagc  ctcggcttc  caatgttag  gaaggagga  gaagcccat  gacccccaa  2160
ccccactga  gcccctact  aggccagcc  cgagccagc  ccagaccca  ccccggtgg  2220
tgaagaggc  gccccctca  ctgtcgagg  gggggccgc  gcggaccct  gcagcgatg  2280
gtctccagg  aagtccccg  ccaaaaaga  gaagaagtt  cgtaccccg  cctttctga  2340
gaagagcaa  aagaagagt  actcctgaa  gccctgcgc  aacactgtc  tgtccggag  2400
gaccctggc  ctgccagcg  ccccggcca  gtctgtgct  tgtccttgt  taatggaat  2460
caaaaaagc  aagccctcc  cctagaggt  ccctcacgt  accagcccc  tgtagcccc  2520
ggctgaccc  gtgtgtgct  agcagcccc  ccccaccct  ccccttgtc  tctcagagc  2580
tcagcttct  ggggagaca  gctctcccc  cagggggga  gcactaagt  atggtcctg  2640
ctggaaggt  ctgaaggct  ctgcagctt  ggctgcacg  caccctcct  agcctcacc  2700
ttcctgccg  ccctcctgt  gtgaaatca  cacattctg  ctctgcttg  cttcccctc  2760
accctaaag  ctcaggtga  ggactcaga  tcctggctt  atgtggcat  ctctctgct  2820
agtgatctc  cttaaatct  tatacaaag  cttggtccc  tgaaaacac  cgtgtgccc  2880
ccagcggcc  tgaagaggc  ggtctgggc  agatgctgg  caggaaacc  cagcggcag  2940
tgggcctgt  tgcacccaa  gtgatgcta  gcatgtctg  ccgacgatc  ctcgaccag  3000
atcagattc  ggagctcag  ttctttttc  cttgggtct  tggattcct  tcataggga  3060
ggtatatca  gaggggaag  ggcctttct  gaattttct  tgagcaggt  tacaattta  3120
cttacattt  tcgactgtg  acgtgaata  gctgctttt  gctttcttc  ttccagacc  3180
cacagtaga  cacttttca  ttatttggg  gaggcttca  gggactgtt  tcaccttaa  3240
tcagccaga  agatgccct  gttgtgatc  aaggtaact  gaggtggag  gtagccctg  3300
ggcccctcg  catcaccgt  attgatgga  cctgaaccg  gtgctcctc  gcagatgct  3360
ttgttgtta  ttccctcca  gaggctgga  aagggctca  agctgctga  caggaaccg  3420
agggtgacc  atttcagga  gtgccggta  cagcctgac  aggtacagg  aagcttgtg  3480
gggcccaac  ggcccttgg  agagctggt  ccagatgtg  gctcagatc  tgggcatga  3540
gggccgagc  acctcggat  ccactgatt  gccagccga  cgagaacca  gctgctgca  3600
ggcactgac  gccgcttcc  gcttcctct  agccgcagg  cctgctacg  gggcaagcg  3660
gctgcctct  ttctgtgtc  ttttgttgc  aaggcagaa  gaaaagtcc  taaccgtgg  3720
ctcttcctt  atcccctcc  ttaccccac  tatgcaatg  cttttaatt  tcacttttg  3780
agtttaatc  tttgtatta  aacatgaaa  atagttgca  atatggaca  cgacttggg  3840
ggacaggtc  tgaatgtcc  ttctccagt  taacatgtt  tactcacaa  taaaattct  3900
tcagcaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaa  3936



<210> 5577
<211> 737
<212> PRT
<213> Homo sapiens
<308> S18207
<400> 5577

Met Asn Gly Asp Ser Arg Ala Ala Val Val Thr Ser Pro Pro Pro Thr 
  1               5                  10                  15
Thr Ala Pro His Lys Glu Arg Tyr Phe Asp Arg Val Asp Glu Asn Asn 
             20                  25                  30
Pro Glu Tyr Leu Arg Glu Arg Asn Met Ala Pro Asp Leu Arg Gln Asp 
         35                  40                  45
Phe Asn Met Met Glu Gln Lys Lys Arg Val Ser Met Ile Leu Gln Ser 
     50                  55                  60
Pro Ala Phe Cys Glu Glu Leu Glu Ser Met Ile Gln Glu Gln Phe Lys 
 65                  70                  75                  80
Lys Gly Lys Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp 
                 85                  90                  95
Phe Met Thr Thr Asn Val Pro Asn Val Tyr Pro Ala Ala Pro Gln Gly 
             100                105                110
Gly Met Ala Ala Leu Asn Met Ser Leu Gly Met Val Thr Pro Val Asn 
         115                120                125
Asp Leu Arg Gly Ser Asp Ser Ile Ala Tyr Asp Lys Gly Glu Lys Leu 
     130                135                140
Leu Arg Cys Lys Leu Ala Ala Phe Tyr Arg Leu Ala Asp Leu Phe Gly 
 145                150                155                160
Trp Ser Gln Leu Ile Tyr Asn His Ile Thr Thr Arg Val Asn Ser Glu 
                 165                170                175
Gln Glu His Phe Leu Ile Val Pro Phe Gly Leu Leu Tyr Ser Glu Val 
             180                185                190
Thr Ala Ser Ser Leu Val Lys Ile Asn Leu Gln Gly Asp Ile Val Asp 
         195                200                205
Arg Gly Ser Thr Asn Leu Gly Val Asn Gln Ala Gly Phe Thr Leu His 
     210                215                220
Ser Ala Ile Tyr Ala Ala Arg Pro Asp Val Lys Cys Val Val His Ile 
 225                230                235                240
His Thr Pro Ala Gly Ala Ala Val Ser Ala Met Lys Cys Gly Leu Leu 
                 245                250                255
Pro Ile Ser Pro Glu Ala Leu Ser Leu Gly Glu Val Ala Tyr His Asp 
             260                265                270
Tyr His Gly Ile Leu Val Asp Glu Glu Glu Lys Val Leu Ile Gln Lys 
         275                280                285
Asn Leu Gly Pro Lys Ser Lys Val Leu Ile Leu Arg Asn His Gly Leu 
     290                295                300
Val Ser Val Gly Glu Ser Val Glu Glu Ala Phe Tyr Tyr Ile His Asn 
 305                310                315                320
Leu Val Val Ala Cys Glu Ile Gln Val Arg Thr Leu Ala Ser Ala Gly 
                 325                330                335
Gly Pro Asp Asn Leu Val Leu Leu Asn Pro Glu Lys Tyr Lys Ala Lys 
             340                345                350
Ser Arg Ser Pro Gly Ser Pro Val Gly Glu Gly Thr Gly Ser Pro Pro 
         355                360                365
Lys Trp Gln Ile Gly Glu Gln Glu Phe Glu Ala Leu Met Arg Met Leu 
     370                375                380
Asp Asn Leu Gly Tyr Arg Thr Gly Tyr Pro Tyr Arg Tyr Pro Ala Leu 
 385                390                395                400
Arg Glu Lys Ser Lys Lys Tyr Ser Asp Val Glu Val Pro Ala Ser Val 
                 405                410                415
Thr Gly Tyr Ser Phe Ala Ser Asp Gly Asp Ser Gly Thr Cys Ser Pro 
             420                425                430
Leu Arg His Ser Phe Gln Lys Gln Gln Arg Glu Lys Thr Arg Trp Leu 
         435                440                445
Asn Ser Gly Arg Gly Asp Glu Ala Ser Glu Glu Gly Gln Asn Gly Ser 
     450                455                460
Ser Pro Lys Ser Lys Thr Lys Trp Thr Lys Glu Asp Gly His Arg Thr 
 465                470                475                480
Ser Thr Ser Ala Val Pro Asn Leu Phe Val Pro Leu Asn Thr Asn Pro 
                 485                490                495
Lys Glu Val Gln Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Leu Gln 
             500                505                510
Asp Ile Lys Thr Ala Gly Pro Gln Ser Gln Val Leu Cys Gly Val Val 
         515                520                525
Met Asp Arg Ser Leu Val Gln Gly Glu Leu Val Thr Ala Ser Lys Ala 
     530                535                540
Ile Ile Glu Lys Glu Tyr Gln Pro His Val Ile Val Ser Thr Thr Gly 
 545                550                555                560
Pro Asn Pro Phe Thr Thr Leu Thr Asp Arg Glu Leu Glu Glu Tyr Arg 
                 565                570                575
Arg Glu Val Glu Arg Lys Gln Lys Gly Ser Glu Glu Asn Leu Asp Glu 
             580                585                590
Ala Arg Glu Gln Lys Glu Lys Ser Pro Pro Asp Gln Pro Ala Val Pro 
         595                600                605
His Pro Pro Pro Ser Thr Pro Ile Lys Leu Glu Glu Asp Leu Val Pro 
     610                615                620
Glu Pro Thr Thr Gly Asp Asp Ser Asp Ala Ala Thr Phe Lys Pro Thr 
 625                630                635                640
Leu Pro Asp Leu Ser Pro Asp Glu Pro Ser Glu Ala Leu Gly Phe Pro 
                 645                650                655
Met Leu Glu Lys Glu Glu Glu Ala His Arg Pro Pro Ser Pro Thr Glu 
             660                665                670
Ala Pro Thr Glu Ala Ser Pro Glu Pro Ala Pro Asp Pro Ala Pro Val 
         675                680                685
Ala Glu Glu Ala Ala Pro Ser Ala Val Glu Glu Gly Ala Ala Ala Asp 
     690                695                700
Pro Gly Ser Asp Gly Ser Pro Gly Lys Ser Pro Ser Lys Lys Lys Lys 
 705                710                715                720
Lys Phe Arg Thr Pro Ser Phe Leu Lys Lys Ser Lys Lys Lys Ser Asp 
                 725                730                735
Ser 
             740



<210> 5578
<211> 546
<212> DNA
<213> Rattus norvegicus
<308> AA891828
<400> 5578

cacttcaaa  cctttatca  aggtgtttc  gtcctgggg  aggggtggc  ttggccttc  60
gaactgatg  taccccttt  ccaggctgg  ggccaaggc  agactgggg  gaaggcctt  120
ggcttctaa  agccttact  cagatggga  gatcggggc  actccaatg  agataaagg  180
ttagggctc  agcttcccc  catggtaga  gaaggaggg  tgtccttgg  gatgcttca  240
gggctgggg  aacaggcag  cgcctctcc  tctggctac  gggagctgg  acagaggcc  300
agaggggcc  atctgtcgc  tcctggtct  gccaacaac  ttgggcagg  tggagcaga  360
caggcagca  cgccgggtt  tgctgaatc  cttgccgca  gttctggaa  tgaggctgg  420
cccgcagga  ctctagggg  ttctcccct  ctgcttctg  ggccggttg  tcgggcgcc  480
ggctttcct  gacagaacc  tgttcaggc  cagggcttc  tggaattcc  gtgagcaag  540
actcca  546



<210> 5579
<211> 1372
<212> PRT
<213> Rattus norvegicus
<308> P02466
<400> 5579

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
  1               5                  10                  15
Ser Cys Leu Ala Thr Cys Gln Ser Leu Gln Met Gly Ser Val Arg Lys 
             20                  25                  30
Gly Pro Thr Gly Asp Arg Gly Pro Arg Gly Gln Arg Gly Pro Ala Gly 
         35                  40                  45
Pro Arg Gly Arg Asp Gly Val Asp Gly Pro Val Gly Pro Pro Gly Pro 
     50                  55                  60
Pro Gly Ala Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Thr 
 65                  70                  75                  80
Gly Asn Phe Ala Ala Gln Tyr Ser Asp Lys Gly Val Ser Ala Gly Pro 
                 85                  90                  95
Gly Pro Met Gly Leu Met Gly Pro Arg Gly Pro Pro Gly Ala Val Gly 
             100                105                110
Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu 
         115                120                125
Pro Gly Gln Thr Gly Pro Ala Gly Ser Arg Gly Pro Ala Gly Pro Pro 
     130                135                140
Gly Lys Ala Gly Glu Asp Gly His Pro Gly Lys Pro Gly Arg Pro Gly 
 145                150                155                160
Glu Arg Gly Val Val Gly Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr 
                 165                170                175
Pro Gly Leu Pro Gly Phe Lys Gly Ile Arg Gly His Asn Gly Leu Asp 
             180                185                190
Gly Leu Lys Gly Gln Pro Gly Ala Gln Gly Val Lys Gly Glu Pro Gly 
         195                200                205
Ala Pro Gly Glu Asn Gly Thr Pro Gly Gln Ala Gly Ala Arg Gly Leu 
     210                215                220
Pro Gly Glu Arg Gly Arg Val Gly Ala Pro Gly Pro Ala Gly Ala Arg 
 225                230                235                240
Gly Ser Asp Gly Ser Val Gly Pro Val Gly Pro Ala Gly Pro Ile Gly 
                 245                250                255
Ser Ala Gly Pro Pro Gly Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu 
             260                265                270
Leu Gly Pro Val Gly Asn Pro Gly Pro Ala Gly Pro Ala Gly Pro Arg 
         275                280                285
Gly Glu Ala Gly Leu Pro Gly Leu Ser Gly Pro Val Gly Pro Pro Gly 
     290                295                300
Asn Pro Gly Ala Asn Gly Leu Thr Gly Ala Lys Gly Ala Thr Gly Leu 
 305                310                315                320
Pro Gly Val Ala Gly Ala Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro 
                 325                330                335
Gly Pro Val Gly Ala Ala Gly Ala Thr Gly Pro Arg Gly Leu Val Gly 
             340                345                350
Glu Pro Gly Pro Ala Gly Ser Lys Gly Glu Thr Gly Asn Lys Gly Glu 
         355                360                365
Pro Gly Ser Ala Gly Ala Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu 
     370                375                380
Gly Lys Arg Gly Ser Pro Gly Glu Pro Gly Ser Ala Gly Pro Ala Gly 
 385                390                395                400
Pro Pro Gly Leu Arg Gly Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala 
                 405                410                415
Asp Gly Arg Ala Gly Val Met Gly Pro Pro Gly Asn Arg Gly Ser Thr 
             420                425                430
Gly Pro Ala Gly Val Arg Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly 
         435                440                445
Glu Pro Gly Leu Met Gly Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn 
     450                455                460
Val Gly Pro Ala Gly Lys Glu Gly Pro Val Gly Leu Pro Gly Ile Asp 
 465                470                475                480
Gly Arg Pro Gly Pro Ile Gly Pro Ala Gly Pro Arg Gly Glu Ala Gly 
                 485                490                495
Asn Ile Gly Phe Pro Gly Pro Lys Gly Pro Ser Gly Asp Pro Gly Lys 
             500                505                510
Pro Gly Glu Lys Gly His Pro Gly Leu Ala Gly Ala Arg Gly Ala Pro 
         515                520                525
Gly Pro Asp Gly Asn Asn Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly 
     530                535                540
Val Gln Gly Gly Lys Gly Glu Gln Gly Pro Ala Gly Pro Pro Gly Phe 
 545                550                555                560
Gln Gly Leu Pro Gly Pro Ser Gly Thr Ala Gly Glu Val Gly Lys Pro 
                 565                570                575
Gly Glu Arg Gly Leu Pro Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly 
             580                585                590
Pro Arg Gly Glu Arg Gly Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro 
         595                600                605
Ser Gly Pro Ile Gly Ile Arg Gly Pro Ser Gly Ala Pro Gly Pro Asp 
     610                615                620
Gly Asn Lys Gly Glu Ala Gly Ala Val Gly Ala Pro Gly Ser Ala Gly 
 625                630                635                640
Ala Ser Gly Pro Gly Gly Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile 
                 645                650                655
Pro Gly Gly Lys Gly Glu Lys Gly Glu Thr Gly Leu Arg Gly Glu Ile 
             660                665                670
Gly Asn Pro Gly Arg Asp Gly Ala Arg Gly Ala Pro Gly Ala Ile Gly 
         675                680                685
Ala Pro Gly Pro Ala Gly Ala Ser Gly Asp Arg Gly Glu Ala Gly Ala 
     690                695                700
Ala Gly Pro Ser Gly Pro Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg 
 705                710                715                720
Gly Glu Val Gly Pro Ala Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly 
                 725                730                735
Ser Ala Gly Gln Pro Gly Ala Lys Gly Glu Lys Gly Thr Lys Gly Pro 
             740                745                750
Lys Gly Glu Asn Gly Ile Val Gly Pro Thr Gly Pro Val Gly Ala Ala 
         755                760                765
Gly Pro Ser Gly Pro Asn Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly 
     770                775                780
Asp Gly Gly Pro Pro Gly Met Thr Gly Phe Pro Gly Ala Ala Gly Arg 
 785                790                795                800
Thr Gly Pro Pro Gly Pro Ser Gly Ile Thr Gly Pro Pro Gly Pro Pro 
                 805                810                815
Gly Ala Ala Gly Lys Glu Gly Ile Arg Gly Pro Arg Gly Asp Gln Gly 
             820                825                830
Pro Val Gly Arg Thr Gly Glu Ile Gly Ala Ser Gly Pro Pro Gly Phe 
         835                840                845
Ala Gly Glu Lys Gly Pro Ser Gly Glu Pro Gly Thr Thr Gly Pro Pro 
     850                855                860
Gly Thr Ala Gly Pro Gln Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly 
 865                870                875                880
Leu Pro Gly Ser Arg Gly Glu Arg Gly Gln Pro Gly Ile Ala Gly Ala 
                 885                890                895
Leu Gly Glu Pro Gly Pro Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg 
             900                905                910
Gly Pro Pro Gly Ala Val Gly Ser Pro Gly Val Asn Gly Ala Pro Gly 
         915                920                925
Glu Ala Gly Arg Asp Gly Asn Pro Gly Ser Asp Gly Pro Pro Gly Arg 
     930                935                940
Asp Gly Gln Pro Gly His Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile 
 945                950                955                960
Gly Pro Thr Gly Ala Ala Gly Ala Pro Gly Pro His Gly Ser Val Gly 
                 965                970                975
Pro Ala Gly Lys His Gly Asn Arg Gly Glu Pro Gly Pro Ala Gly Ser 
             980                985                990
Val Gly Pro Val Gly Ala Val Gly Pro Arg Gly Pro Ser Gly Pro Gln 
         995                1000                1005
Gly Ile Arg Gly Asp Lys Gly Glu Pro Gly Asp Lys Gly Ala Arg Gly 
     1010                1015                1020
Leu Pro Gly Leu Lys Gly His Asn Gly Leu Gln Gly Leu Pro Gly Leu 
 1025                1030                1035                1040
Ala Gly Leu His Gly Asp Gln Gly Ala Pro Gly Pro Val Gly Pro Ala 
                 1045                1050                1055
Gly Pro Arg Gly Pro Ala Gly Pro Ser Gly Pro Ile Gly Lys Asp Gly 
             1060                1065                1070
Arg Ser Gly His Pro Gly Pro Val Gly Pro Ala Gly Val Arg Gly Ser 
         1075                1080                1085
Gln Gly Ser Gln Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro 
     1090                1095                1100
Gly Pro Pro Gly Val Ser Gly Gly Gly Tyr Asp Phe Gly Phe Glu Gly 
 1105                1110                1115                1120
Gly Phe Tyr Arg Ala Asp Gln Pro Arg Ser Gln Pro Ser Leu Arg Pro 
                 1125                1130                1135
Lys Asp Tyr Glu Val Asp Ala Thr Leu Lys Ser Leu Asn Asn Gln Ile 
             1140                1145                1150
Glu Thr Leu Leu Thr Pro Glu Gly Ser Arg Lys Asn Pro Ala Arg Thr 
         1155                1160                1165
Cys Arg Asp Leu Arg Leu Ser His Pro Glu Trp Lys Ser Asp Tyr Tyr 
     1170                1175                1180
Trp Ile Asp Pro Asn Gln Gly Cys Thr Met Asp Ala Ile Lys Val Tyr 
 1185                1190                1195                1200
Cys Asp Phe Ser Thr Gly Glu Thr Cys Ile Gln Ala Gln Pro Val Asn 
                 1205                1210                1215
Thr Pro Ala Lys Asn Ala Tyr Ser Arg Ala Gln Ala Asn Lys His Val 
             1220                1225                1230
Trp Leu Gly Glu Thr Ile Asn Gly Gly Ser Gln Phe Glu Tyr Asn Ala 
         1235                1240                1245
Glu Gly Val Ser Ser Lys Glu Met Ala Thr Gln Leu Ala Phe Met Arg 
     1250                1255                1260
Leu Leu Ala Asn Arg Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn 
 1265                1270                1275                1280
Ser Ile Ala Tyr Leu Asp Glu Glu Thr Gly Arg Leu Asn Lys Ala Val 
                 1285                1290                1295
Ile Leu Gln Gly Ser Asn Asp Val Glu Leu Val Ala Glu Gly Asn Ser 
             1300                1305                1310
Arg Phe Thr Tyr Thr Val Leu Val Asp Gly Cys Ser Lys Lys Thr Asn 
         1315                1320                1325
Glu Trp Asp Lys Thr Val Ile Glu Tyr Lys Thr Asn Lys Pro Ser Arg 
     1330                1335                1340
Leu Pro Phe Leu Asp Ile Ala Pro Leu Asp Ile Gly Gly Thr Asn Gln 
 1345                1350                1355                1360
Glu Phe Arg Val Glu Val Gly Pro Val Cys Phe Lys 
                 1365                1370



<210> 5580
<211> 1719
<212> DNA
<213> Homo sapiens
<308> D21235
<400> 5580

gggatcccg  ggccgccgc  tcgctcggg  cccgccatg  ccgtcacca  cacgctcaa  60
acgctgcag  agcagacct  caagatccg  atggagcct  acgagacgg  gaaggtgct  120
aaggagaag  tagaagctg  gaagggtcg  gatgccttc  ccgtggctg  acagaaact  180
atctatgcc  gcaagatct  gagtgacga  gtccctatc  gggactatc  catcgatga  240
aagaacttt  tggtcgtca  ggtgaccaa  accaaagcc  gccagggta  ctcagcacc  300
ccagaggcc  cacccacag  tgccccaga  tcctctaca  ccttcccgc  tgcccccac  360
tcaggcatg  cccatcccc  acctgccgc  agagaggac  agagcccat  agaggaatc  420
gcccccacg  cgtccccag  gtctgtgtc  ggctctgtt  cctcttcag  tagcagcgg  480
cgagaggaa  acgcggcct  cacgctagt  acgggctct  agtatgaga  gatgctgac  540
gagatcatg  ccatgggct  tgagcgaga  cgggtcgtg  ccgccctga  agccagcta  600
aacaacccc  accgagccg  ggagtatct  ctcacggga  ttcctggga  ccccgagcc  660
gaacacggt  ctgtccagg  gagccaggt  tcggagcag  cggccacgg  agcagcagg  720
gagaacccc  tggagttcc  gcgggacca  ccccagttc  agaacatgc  gcaggtgat  780
cagcagaac  ctgcgctgc  gcccgccct  ctccagcag  tgggccagg  gaaccctca  840
cttttacag  aaatcagcc  gcaccagga  cagttcatc  agatgctga  cgagccccc  900
ggggagctg  cggacatct  agatgtgga  ggggaggtg  gcgccatag  agaggaggc  960
ccgcagatg  actacatcc  ggtgacgcc  caggagaaa  aagctatag  gaggttgaa  1020
gccctgggc  tcccagaga  cctggtcat  caggcctat  tcgcgtgtg  aaaaaatga  1080
aacttggct  ccaacttcc  cctgagtca  aactttgat  acgagtgat  ccaggaagc  1140
aggccaccg  agcccccac  ctaccctta  tccatgaaa  ttttataaa  gaaaaaata  1200
atatatatt  atgtttatt  aagaaatgg  aaaaaaaat  aaaaatctt  aaaaaacaa  1260
caaacagtc  agcttcctg  cctcctaaa  tggcccctg  tcccatctc  cgggccaga  1320
agctgtccc  ccgtcctcc  ccccagccc  gcctgctca  agaagctgg  aggactggg  1380
ggcgacaga  gggcccctc  tggcctctg  cccagctct  tgcagccag  cggaaaggc  1440
gctgcttgc  tctccatcc  ccgaaaaac  cctgaggac  cccccccat  ctcttctag  1500
atgagggga  gctggagcc  caactttga  cctccattg  agtggccca  atctttcca  1560
ctagggcaa  tcctgaaag  cccaaggcc  cctcccagt  tggccttgg  ctccagcct  1620
gagaagggc  aacatcagc  cattgtcaa  gccaccccc  ccccagaac  gaaccgtgt  1680
tctgataaa  gttttgaag  gaataaagt  ttaaaaact  1719



<210> 5581
<211> 363
<212> PRT
<213> Homo sapiens
<308> P54725
<400> 5581

Met Ala Val Thr Ile Thr Leu Lys Thr Leu Gln Gln Gln Thr Phe Lys 
  1               5                  10                  15
Ile Arg Met Glu Pro Asp Glu Thr Val Lys Val Leu Lys Glu Lys Ile 
             20                  25                  30
Glu Ala Glu Lys Gly Arg Asp Ala Phe Pro Val Ala Gly Gln Lys Leu 
         35                  40                  45
Ile Tyr Ala Gly Lys Ile Leu Ser Asp Asp Val Pro Ile Arg Asp Tyr 
     50                  55                  60
Arg Ile Asp Glu Lys Asn Phe Val Val Val Met Val Thr Lys Thr Lys 
 65                  70                  75                  80
Ala Gly Gln Gly Thr Ser Ala Pro Pro Glu Ala Ser Pro Thr Ala Ala 
                 85                  90                  95
Pro Glu Ser Ser Thr Ser Phe Pro Pro Ala Pro Thr Ser Gly Met Ser 
             100                105                110
His Pro Pro Pro Ala Ala Arg Glu Asp Lys Ser Pro Ser Glu Glu Ser 
         115                120                125
Ala Pro Thr Thr Ser Pro Glu Ser Val Ser Gly Ser Val Pro Ser Ser 
     130                135                140
Gly Ser Ser Gly Arg Glu Glu Asp Ala Ala Ser Thr Leu Val Thr Gly 
 145                150                155                160
Ser Glu Tyr Glu Thr Met Leu Thr Glu Ile Met Ser Met Gly Tyr Glu 
                 165                170                175
Arg Glu Arg Val Val Ala Ala Leu Arg Ala Ser Tyr Asn Asn Pro His 
             180                185                190
Arg Ala Val Glu Tyr Leu Leu Thr Gly Ile Pro Gly Ser Pro Glu Pro 
         195                200                205
Glu His Gly Ser Val Gln Glu Ser Gln Val Ser Glu Gln Pro Ala Thr 
     210                215                220
Glu Ala Ala Gly Glu Asn Pro Leu Glu Phe Leu Arg Asp Gln Pro Gln 
 225                230                235                240
Phe Gln Asn Met Arg Gln Val Ile Gln Gln Asn Pro Ala Leu Leu Pro 
                 245                250                255
Ala Leu Leu Gln Gln Leu Gly Gln Glu Asn Pro Gln Leu Leu Gln Gln 
             260                265                270
Ile Ser Arg His Gln Glu Gln Phe Ile Gln Met Leu Asn Glu Pro Pro 
         275                280                285
Gly Glu Leu Ala Asp Ile Ser Asp Val Glu Gly Glu Val Gly Ala Ile 
     290                295                300
Gly Glu Glu Ala Pro Gln Met Asn Tyr Ile Gln Val Thr Pro Gln Glu 
 305                310                315                320
Lys Glu Ala Ile Glu Arg Leu Lys Ala Leu Gly Phe Pro Glu Ser Leu 
                 325                330                335
Val Ile Gln Ala Tyr Phe Ala Cys Glu Lys Asn Glu Asn Leu Ala Ala 
             340                345                350
Asn Phe Leu Leu Ser Gln Asn Phe Asp Asp Glu 
         355                360



<210> 5582
<211> 546
<212> DNA
<213> Rattus norvegicus
<308> AA891828
<400> 5582

cacttcaaa  cctttatca  aggtgtttc  gtcctgggg  aggggtggc  ttggccttc  60
gaactgatg  taccccttt  ccaggctgg  ggccaaggc  agactgggg  gaaggcctt  120
ggcttctaa  agccttact  cagatggga  gatcggggc  actccaatg  agataaagg  180
ttagggctc  agcttcccc  catggtaga  gaaggaggg  tgtccttgg  gatgcttca  240
gggctgggg  aacaggcag  cgcctctcc  tctggctac  gggagctgg  acagaggcc  300
agaggggcc  atctgtcgc  tcctggtct  gccaacaac  ttgggcagg  tggagcaga  360
caggcagca  cgccgggtt  tgctgaatc  cttgccgca  gttctggaa  tgaggctgg  420
cccgcagga  ctctagggg  ttctcccct  ctgcttctg  ggccggttg  tcgggcgcc  480
ggctttcct  gacagaacc  tgttcaggc  cagggcttc  tggaattcc  gtgagcaag  540
actcca  546



<210> 5583
<211> 1372
<212> PRT
<213> Rattus norvegicus
<308> P02466
<400> 5583

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
  1               5                  10                  15
Ser Cys Leu Ala Thr Cys Gln Ser Leu Gln Met Gly Ser Val Arg Lys 
             20                  25                  30
Gly Pro Thr Gly Asp Arg Gly Pro Arg Gly Gln Arg Gly Pro Ala Gly 
         35                  40                  45
Pro Arg Gly Arg Asp Gly Val Asp Gly Pro Val Gly Pro Pro Gly Pro 
     50                  55                  60
Pro Gly Ala Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Thr 
 65                  70                  75                  80
Gly Asn Phe Ala Ala Gln Tyr Ser Asp Lys Gly Val Ser Ala Gly Pro 
                 85                  90                  95
Gly Pro Met Gly Leu Met Gly Pro Arg Gly Pro Pro Gly Ala Val Gly 
             100                105                110
Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu 
         115                120                125
Pro Gly Gln Thr Gly Pro Ala Gly Ser Arg Gly Pro Ala Gly Pro Pro 
     130                135                140
Gly Lys Ala Gly Glu Asp Gly His Pro Gly Lys Pro Gly Arg Pro Gly 
 145                150                155                160
Glu Arg Gly Val Val Gly Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr 
                 165                170                175
Pro Gly Leu Pro Gly Phe Lys Gly Ile Arg Gly His Asn Gly Leu Asp 
             180                185                190
Gly Leu Lys Gly Gln Pro Gly Ala Gln Gly Val Lys Gly Glu Pro Gly 
         195                200                205
Ala Pro Gly Glu Asn Gly Thr Pro Gly Gln Ala Gly Ala Arg Gly Leu 
     210                215                220
Pro Gly Glu Arg Gly Arg Val Gly Ala Pro Gly Pro Ala Gly Ala Arg 
 225                230                235                240
Gly Ser Asp Gly Ser Val Gly Pro Val Gly Pro Ala Gly Pro Ile Gly 
                 245                250                255
Ser Ala Gly Pro Pro Gly Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu 
             260                265                270
Leu Gly Pro Val Gly Asn Pro Gly Pro Ala Gly Pro Ala Gly Pro Arg 
         275                280                285
Gly Glu Ala Gly Leu Pro Gly Leu Ser Gly Pro Val Gly Pro Pro Gly 
     290                295                300
Asn Pro Gly Ala Asn Gly Leu Thr Gly Ala Lys Gly Ala Thr Gly Leu 
 305                310                315                320
Pro Gly Val Ala Gly Ala Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro 
                 325                330                335
Gly Pro Val Gly Ala Ala Gly Ala Thr Gly Pro Arg Gly Leu Val Gly 
             340                345                350
Glu Pro Gly Pro Ala Gly Ser Lys Gly Glu Thr Gly Asn Lys Gly Glu 
         355                360                365
Pro Gly Ser Ala Gly Ala Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu 
     370                375                380
Gly Lys Arg Gly Ser Pro Gly Glu Pro Gly Ser Ala Gly Pro Ala Gly 
 385                390                395                400
Pro Pro Gly Leu Arg Gly Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala 
                 405                410                415
Asp Gly Arg Ala Gly Val Met Gly Pro Pro Gly Asn Arg Gly Ser Thr 
             420                425                430
Gly Pro Ala Gly Val Arg Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly 
         435                440                445
Glu Pro Gly Leu Met Gly Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn 
     450                455                460
Val Gly Pro Ala Gly Lys Glu Gly Pro Val Gly Leu Pro Gly Ile Asp 
 465                470                475                480
Gly Arg Pro Gly Pro Ile Gly Pro Ala Gly Pro Arg Gly Glu Ala Gly 
                 485                490                495
Asn Ile Gly Phe Pro Gly Pro Lys Gly Pro Ser Gly Asp Pro Gly Lys 
             500                505                510
Pro Gly Glu Lys Gly His Pro Gly Leu Ala Gly Ala Arg Gly Ala Pro 
         515                520                525
Gly Pro Asp Gly Asn Asn Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly 
     530                535                540
Val Gln Gly Gly Lys Gly Glu Gln Gly Pro Ala Gly Pro Pro Gly Phe 
 545                550                555                560
Gln Gly Leu Pro Gly Pro Ser Gly Thr Ala Gly Glu Val Gly Lys Pro 
                 565                570                575
Gly Glu Arg Gly Leu Pro Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly 
             580                585                590
Pro Arg Gly Glu Arg Gly Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro 
         595                600                605
Ser Gly Pro Ile Gly Ile Arg Gly Pro Ser Gly Ala Pro Gly Pro Asp 
     610                615                620
Gly Asn Lys Gly Glu Ala Gly Ala Val Gly Ala Pro Gly Ser Ala Gly 
 625                630                635                640
Ala Ser Gly Pro Gly Gly Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile 
                 645                650                655
Pro Gly Gly Lys Gly Glu Lys Gly Glu Thr Gly Leu Arg Gly Glu Ile 
             660                665                670
Gly Asn Pro Gly Arg Asp Gly Ala Arg Gly Ala Pro Gly Ala Ile Gly 
         675                680                685
Ala Pro Gly Pro Ala Gly Ala Ser Gly Asp Arg Gly Glu Ala Gly Ala 
     690                695                700
Ala Gly Pro Ser Gly Pro Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg 
 705                710                715                720
Gly Glu Val Gly Pro Ala Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly 
                 725                730                735
Ser Ala Gly Gln Pro Gly Ala Lys Gly Glu Lys Gly Thr Lys Gly Pro 
             740                745                750
Lys Gly Glu Asn Gly Ile Val Gly Pro Thr Gly Pro Val Gly Ala Ala 
         755                760                765
Gly Pro Ser Gly Pro Asn Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly 
     770                775                780
Asp Gly Gly Pro Pro Gly Met Thr Gly Phe Pro Gly Ala Ala Gly Arg 
 785                790                795                800
Thr Gly Pro Pro Gly Pro Ser Gly Ile Thr Gly Pro Pro Gly Pro Pro 
                 805                810                815
Gly Ala Ala Gly Lys Glu Gly Ile Arg Gly Pro Arg Gly Asp Gln Gly 
             820                825                830
Pro Val Gly Arg Thr Gly Glu Ile Gly Ala Ser Gly Pro Pro Gly Phe 
         835                840                845
Ala Gly Glu Lys Gly Pro Ser Gly Glu Pro Gly Thr Thr Gly Pro Pro 
     850                855                860
Gly Thr Ala Gly Pro Gln Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly 
 865                870                875                880
Leu Pro Gly Ser Arg Gly Glu Arg Gly Gln Pro Gly Ile Ala Gly Ala 
                 885                890                895
Leu Gly Glu Pro Gly Pro Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg 
             900                905                910
Gly Pro Pro Gly Ala Val Gly Ser Pro Gly Val Asn Gly Ala Pro Gly 
         915                920                925
Glu Ala Gly Arg Asp Gly Asn Pro Gly Ser Asp Gly Pro Pro Gly Arg 
     930                935                940
Asp Gly Gln Pro Gly His Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile 
 945                950                955                960
Gly Pro Thr Gly Ala Ala Gly Ala Pro Gly Pro His Gly Ser Val Gly 
                 965                970                975
Pro Ala Gly Lys His Gly Asn Arg Gly Glu Pro Gly Pro Ala Gly Ser 
             980                985                990
Val Gly Pro Val Gly Ala Val Gly Pro Arg Gly Pro Ser Gly Pro Gln 
         995                1000                1005
Gly Ile Arg Gly Asp Lys Gly Glu Pro Gly Asp Lys Gly Ala Arg Gly 
     1010                1015                1020
Leu Pro Gly Leu Lys Gly His Asn Gly Leu Gln Gly Leu Pro Gly Leu 
 1025                1030                1035                1040
Ala Gly Leu His Gly Asp Gln Gly Ala Pro Gly Pro Val Gly Pro Ala 
                 1045                1050                1055
Gly Pro Arg Gly Pro Ala Gly Pro Ser Gly Pro Ile Gly Lys Asp Gly 
             1060                1065                1070
Arg Ser Gly His Pro Gly Pro Val Gly Pro Ala Gly Val Arg Gly Ser 
         1075                1080                1085
Gln Gly Ser Gln Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro 
     1090                1095                1100
Gly Pro Pro Gly Val Ser Gly Gly Gly Tyr Asp Phe Gly Phe Glu Gly 
 1105                1110                1115                1120
Gly Phe Tyr Arg Ala Asp Gln Pro Arg Ser Gln Pro Ser Leu Arg Pro 
                 1125                1130                1135
Lys Asp Tyr Glu Val Asp Ala Thr Leu Lys Ser Leu Asn Asn Gln Ile 
             1140                1145                1150
Glu Thr Leu Leu Thr Pro Glu Gly Ser Arg Lys Asn Pro Ala Arg Thr 
         1155                1160                1165
Cys Arg Asp Leu Arg Leu Ser His Pro Glu Trp Lys Ser Asp Tyr Tyr 
     1170                1175                1180
Trp Ile Asp Pro Asn Gln Gly Cys Thr Met Asp Ala Ile Lys Val Tyr 
 1185                1190                1195                1200
Cys Asp Phe Ser Thr Gly Glu Thr Cys Ile Gln Ala Gln Pro Val Asn 
                 1205                1210                1215
Thr Pro Ala Lys Asn Ala Tyr Ser Arg Ala Gln Ala Asn Lys His Val 
             1220                1225                1230
Trp Leu Gly Glu Thr Ile Asn Gly Gly Ser Gln Phe Glu Tyr Asn Ala 
         1235                1240                1245
Glu Gly Val Ser Ser Lys Glu Met Ala Thr Gln Leu Ala Phe Met Arg 
     1250                1255                1260
Leu Leu Ala Asn Arg Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn 
 1265                1270                1275                1280
Ser Ile Ala Tyr Leu Asp Glu Glu Thr Gly Arg Leu Asn Lys Ala Val 
                 1285                1290                1295
Ile Leu Gln Gly Ser Asn Asp Val Glu Leu Val Ala Glu Gly Asn Ser 
             1300                1305                1310
Arg Phe Thr Tyr Thr Val Leu Val Asp Gly Cys Ser Lys Lys Thr Asn 
         1315                1320                1325
Glu Trp Asp Lys Thr Val Ile Glu Tyr Lys Thr Asn Lys Pro Ser Arg 
     1330                1335                1340
Leu Pro Phe Leu Asp Ile Ala Pro Leu Asp Ile Gly Gly Thr Asn Gln 
 1345                1350                1355                1360
Glu Phe Arg Val Glu Val Gly Pro Val Cys Phe Lys 
                 1365                1370



<210> 5584
<211> 1719
<212> DNA
<213> Homo sapiens
<308> D21235
<400> 5584

gggatcccg  ggccgccgc  tcgctcggg  cccgccatg  ccgtcacca  cacgctcaa  60
acgctgcag  agcagacct  caagatccg  atggagcct  acgagacgg  gaaggtgct  120
aaggagaag  tagaagctg  gaagggtcg  gatgccttc  ccgtggctg  acagaaact  180
atctatgcc  gcaagatct  gagtgacga  gtccctatc  gggactatc  catcgatga  240
aagaacttt  tggtcgtca  ggtgaccaa  accaaagcc  gccagggta  ctcagcacc  300
ccagaggcc  cacccacag  tgccccaga  tcctctaca  ccttcccgc  tgcccccac  360
tcaggcatg  cccatcccc  acctgccgc  agagaggac  agagcccat  agaggaatc  420
gcccccacg  cgtccccag  gtctgtgtc  ggctctgtt  cctcttcag  tagcagcgg  480
cgagaggaa  acgcggcct  cacgctagt  acgggctct  agtatgaga  gatgctgac  540
gagatcatg  ccatgggct  tgagcgaga  cgggtcgtg  ccgccctga  agccagcta  600
aacaacccc  accgagccg  ggagtatct  ctcacggga  ttcctggga  ccccgagcc  660
gaacacggt  ctgtccagg  gagccaggt  tcggagcag  cggccacgg  agcagcagg  720
gagaacccc  tggagttcc  gcgggacca  ccccagttc  agaacatgc  gcaggtgat  780
cagcagaac  ctgcgctgc  gcccgccct  ctccagcag  tgggccagg  gaaccctca  840
cttttacag  aaatcagcc  gcaccagga  cagttcatc  agatgctga  cgagccccc  900
ggggagctg  cggacatct  agatgtgga  ggggaggtg  gcgccatag  agaggaggc  960
ccgcagatg  actacatcc  ggtgacgcc  caggagaaa  aagctatag  gaggttgaa  1020
gccctgggc  tcccagaga  cctggtcat  caggcctat  tcgcgtgtg  aaaaaatga  1080
aacttggct  ccaacttcc  cctgagtca  aactttgat  acgagtgat  ccaggaagc  1140
aggccaccg  agcccccac  ctaccctta  tccatgaaa  ttttataaa  gaaaaaata  1200
atatatatt  atgtttatt  aagaaatgg  aaaaaaaat  aaaaatctt  aaaaaacaa  1260
caaacagtc  agcttcctg  cctcctaaa  tggcccctg  tcccatctc  cgggccaga  1320
agctgtccc  ccgtcctcc  ccccagccc  gcctgctca  agaagctgg  aggactggg  1380
ggcgacaga  gggcccctc  tggcctctg  cccagctct  tgcagccag  cggaaaggc  1440
gctgcttgc  tctccatcc  ccgaaaaac  cctgaggac  cccccccat  ctcttctag  1500
atgagggga  gctggagcc  caactttga  cctccattg  agtggccca  atctttcca  1560
ctagggcaa  tcctgaaag  cccaaggcc  cctcccagt  tggccttgg  ctccagcct  1620
gagaagggc  aacatcagc  cattgtcaa  gccaccccc  ccccagaac  gaaccgtgt  1680
tctgataaa  gttttgaag  gaataaagt  ttaaaaact  1719



<210> 5585
<211> 363
<212> PRT
<213> Homo sapiens
<308> P54725
<400> 5585

Met Ala Val Thr Ile Thr Leu Lys Thr Leu Gln Gln Gln Thr Phe Lys 
  1               5                  10                  15
Ile Arg Met Glu Pro Asp Glu Thr Val Lys Val Leu Lys Glu Lys Ile 
             20                  25                  30
Glu Ala Glu Lys Gly Arg Asp Ala Phe Pro Val Ala Gly Gln Lys Leu 
         35                  40                  45
Ile Tyr Ala Gly Lys Ile Leu Ser Asp Asp Val Pro Ile Arg Asp Tyr 
     50                  55                  60
Arg Ile Asp Glu Lys Asn Phe Val Val Val Met Val Thr Lys Thr Lys 
 65                  70                  75                  80
Ala Gly Gln Gly Thr Ser Ala Pro Pro Glu Ala Ser Pro Thr Ala Ala 
                 85                  90                  95
Pro Glu Ser Ser Thr Ser Phe Pro Pro Ala Pro Thr Ser Gly Met Ser 
             100                105                110
His Pro Pro Pro Ala Ala Arg Glu Asp Lys Ser Pro Ser Glu Glu Ser 
         115                120                125
Ala Pro Thr Thr Ser Pro Glu Ser Val Ser Gly Ser Val Pro Ser Ser 
     130                135                140
Gly Ser Ser Gly Arg Glu Glu Asp Ala Ala Ser Thr Leu Val Thr Gly 
 145                150                155                160
Ser Glu Tyr Glu Thr Met Leu Thr Glu Ile Met Ser Met Gly Tyr Glu 
                 165                170                175
Arg Glu Arg Val Val Ala Ala Leu Arg Ala Ser Tyr Asn Asn Pro His 
             180                185                190
Arg Ala Val Glu Tyr Leu Leu Thr Gly Ile Pro Gly Ser Pro Glu Pro 
         195                200                205
Glu His Gly Ser Val Gln Glu Ser Gln Val Ser Glu Gln Pro Ala Thr 
     210                215                220
Glu Ala Ala Gly Glu Asn Pro Leu Glu Phe Leu Arg Asp Gln Pro Gln 
 225                230                235                240
Phe Gln Asn Met Arg Gln Val Ile Gln Gln Asn Pro Ala Leu Leu Pro 
                 245                250                255
Ala Leu Leu Gln Gln Leu Gly Gln Glu Asn Pro Gln Leu Leu Gln Gln 
             260                265                270
Ile Ser Arg His Gln Glu Gln Phe Ile Gln Met Leu Asn Glu Pro Pro 
         275                280                285
Gly Glu Leu Ala Asp Ile Ser Asp Val Glu Gly Glu Val Gly Ala Ile 
     290                295                300
Gly Glu Glu Ala Pro Gln Met Asn Tyr Ile Gln Val Thr Pro Gln Glu 
 305                310                315                320
Lys Glu Ala Ile Glu Arg Leu Lys Ala Leu Gly Phe Pro Glu Ser Leu 
                 325                330                335
Val Ile Gln Ala Tyr Phe Ala Cys Glu Lys Asn Glu Asn Leu Ala Ala 
             340                345                350
Asn Phe Leu Leu Ser Gln Asn Phe Asp Asp Glu 
         355                360



<210> 5586
<211> 686
<212> DNA
<213> Rattus norvegicus
<308> AA891829
<400> 5586

atattttat  aatatattt  cccccaaaa  gtaacacct  ccctaaatc  agcaaaact  60
taatattta  tattaaata  taaatattt  atattctgc  gttccgtgg  tctgtccaa  120
ggctttctc  catcaaggg  aacagtgaa  ggtcctgag  taaatgaaa  tcaaggatg  180
ttcaggtct  ctcagtgac  aggaaaagt  ttaggacat  ttctgtggg  atcaagatc  240
ccaagtcaa  ctgcagctc  gagacctgc  ggctgatga  actcccaga  ggctacctc  300
ccatcatca  tacaagagg  caggagccc  gcctccttg  ggttccaag  cacacagtt  360
acatcctgg  aatgggcct  acgaagatg  gctgtcaaa  agaaggtgg  ctgctgtgg  420
tctgagcct  gatcttcct  aaacactcg  atggcatca  ctccacaag  tgtagccag  480
gcccctgtc  gctgacacc  agcaacgtc  tagatggtc  tggtatgga  gcccgacaa  540
gtgcaaaca  atttccagc  ggggtcgga  ccactgcat  ccacccctt  ttcattgcc  600
ggtagatac  ggcgccaga  gcgcacagt  cggtcatca  tgcaagatg  cagacgctg  660
ncgctggga  caaaggcta  gctcca  686



<210> 5587
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> P22288
<400> 5587

Met Glu Lys Pro Arg Gly Val Arg Cys Thr Asn Gly Phe Pro Glu Arg 
  1               5                  10                  15
Glu Leu Pro Arg Pro Gly Ala Ser Arg Pro Ala Glu Lys Ser Arg Pro 
             20                  25                  30
Pro Glu Ala Lys Gly Ala Gln Pro Ala Asp Ala Trp Lys Ala Gly Arg 
         35                  40                  45
Pro Arg Ser Glu Glu Asp Asn Glu Leu Asn Leu Pro Asn Leu Ala Ala 
     50                  55                  60
Ala Tyr Ser Ser Ile Leu Arg Ser Leu Gly Glu Asp Pro Gln Arg Gln 
 65                  70                  75                  80
Gly Leu Leu Lys Thr Pro Trp Arg Ala Ala Thr Ala Met Gln Phe Phe 
                 85                  90                  95
Thr Lys Gly Tyr Gln Glu Thr Ile Ser Asp Val Leu Asn Asp Ala Ile 
             100                105                110
Phe Asp Glu Asp His Asp Glu Met Val Ile Val Lys Asp Ile Asp Met 
         115                120                125
Phe Ser Met Cys Glu His His Leu Val Pro Phe Val Gly Arg Val His 
     130                135                140
Ile Gly Tyr Leu Pro Asn Lys Gln Val Leu Gly Leu Ser Lys Leu Ala 
 145                150                155                160
Arg Ile Val Glu Ile Tyr Ser Arg Arg Leu Gln Val Gln Glu Arg Leu 
                 165                170                175
Thr Lys Gln Ile Ala Val Ala Ile Thr Glu Ala Leu Gln Pro Ala Gly 
             180                185                190
Val Gly Val Val Ile Glu Ala Thr His Met Cys Met Val Met Arg Gly 
         195                200                205
Val Gln Lys Met Asn Ser Lys Thr Val Thr Ser Thr Met Leu Gly Val 
     210                215                220
Phe Arg Glu Asp Pro Lys Thr Arg Glu Glu Phe Leu Thr Leu Ile Arg 
 225                230                235                240
Ser 
                 245



<210> 5588
<211> 1413
<212> DNA
<213> Homo sapiens
<308> U63810
<400> 5588

ggtgagttt  cggggcgac  caggtcctc  ggcggaacg  ggagcctct  tcggccgcg  60
aagcctgga  tgggcggta  gcagacgcg  gcggcgaga  ccgctgtct  ctcagcgga  120
tctgcccgc  cccacctcc  cctgcgtcg  gccgacatg  aggactcgc  ggtgctgct  180
ggccgtgtc  cggcgcacc  ggactcccg  tgctggttc  tggcctgga  ccccgcggg  240
accctgctg  cctcgtgcg  cggcgaccg  agaatccgc  tctggggca  ggagggtga  300
agctggatc  gcaagtctg  cctttctga  ggccaccag  gcaccgtgc  gaaggtagc  360
tggtccccc  gcggtaatt  cctggcctc  gccagcttt  atgctacca  ttgcatttg  420
aagaagaac  aggatgact  tgagtgtgt  accactctc  agggccatg  aaatgaggt  480
aagtcagtg  cttgggccc  atctggcaa  ctcctggcc  cttgcagcc  agataagag  540
gtttgggtc  gggaagttg  tgaagagga  gagtatgaa  gtgtcagtg  tctcaactc  600
cacacacag  atgtcaagc  tgtggtttg  cacccaagt  aggagctct  agcttctgc  660
agctatgat  acacagtga  gctgtaccg  gaggaagag  atgactggg  atgctgtgc  720
acccttgag  gccatgaat  cactgtgtg  agcttggcc  ttgacccga  tggccagcg  780
ctggcgtct  gtagtgatg  ccgtactgt  cgtatctgg  gtcagtatc  accaggcaa  840
gaacaaggg  tggcatgca  cggctctga  cccagttgg  aatgtatct  tactttgtc  900
ggcttccac  caaggacca  ttatgacat  gcttggtgt  agctgacag  ggctctggc  960
acagcttgt  gggatgacg  gatccgcgt  tttcaggag  atcccaact  ggatccaca  1020
cagcccacc  tctccctga  agcccactt  catcaggcc  attcccagg  tgtcaactg  1080
gtggcctgg  accccaagg  gccagggct  ctggcctcc  gcagtgatg  tggggaggt  1140
gccttctgg  agtatcagc  gcctgaagg  ctctgagct  ccacgtctt  ggacagagt  1200
atgactccc  agaaaacgt  atataagac  tttaccagc  cctgagagg  ccaggagga  1260
catccttga  cttcattta  cttggctca  ttctcttca  acttgggta  aagtgcaga  1320
ccacagaat  gctttcctt  cccgccttt  acatgaggc  ttcagtaaa  agctacaga  1380
catgaaaaa  aaaaaaaaa  aaaaaaaaa  aaa  1413



<210> 5589
<211> 339
<212> PRT
<213> Homo sapiens
<308> O76071
<400> 5589

Met Lys Asp Ser Leu Val Leu Leu Gly Arg Val Pro Ala His Pro Asp 
  1               5                  10                  15
Ser Arg Cys Trp Phe Leu Ala Trp Asn Pro Ala Gly Thr Leu Leu Ala 
             20                  25                  30
Ser Cys Gly Gly Asp Arg Arg Ile Arg Ile Trp Gly Thr Glu Gly Asp 
         35                  40                  45
Ser Trp Ile Cys Lys Ser Val Leu Ser Glu Gly His Gln Arg Thr Val 
     50                  55                  60
Arg Lys Val Ala Trp Ser Pro Cys Gly Asn Tyr Leu Ala Ser Ala Ser 
 65                  70                  75                  80
Phe Asp Ala Thr Thr Cys Ile Trp Lys Lys Asn Gln Asp Asp Phe Glu 
                 85                  90                  95
Cys Val Thr Thr Leu Glu Gly His Glu Asn Glu Val Lys Ser Val Ala 
             100                105                110
Trp Ala Pro Ser Gly Asn Leu Leu Ala Thr Cys Ser Arg Asp Lys Ser 
         115                120                125
Val Trp Val Trp Glu Val Asp Glu Glu Asp Glu Tyr Glu Cys Val Ser 
     130                135                140
Val Leu Asn Ser His Thr Gln Asp Val Lys His Val Val Trp His Pro 
 145                150                155                160
Ser Gln Glu Leu Leu Ala Ser Ala Ser Tyr Asp Asp Thr Val Lys Leu 
                 165                170                175
Tyr Arg Glu Glu Glu Asp Asp Trp Val Cys Cys Ala Thr Leu Glu Gly 
             180                185                190
His Glu Ser Thr Val Trp Ser Leu Ala Phe Asp Pro Ser Gly Gln Arg 
         195                200                205
Leu Ala Ser Cys Ser Asp Asp Arg Thr Val Arg Ile Trp Arg Gln Tyr 
     210                215                220
Leu Pro Gly Asn Glu Gln Gly Val Ala Cys Ser Gly Ser Asp Pro Ser 
 225                230                235                240
Trp Lys Cys Ile Cys Thr Leu Ser Gly Phe His Ser Arg Thr Ile Tyr 
                 245                250                255
Asp Ile Ala Trp Cys Gln Leu Thr Gly Ala Leu Ala Thr Ala Cys Gly 
             260                265                270
Asp Asp Ala Ile Arg Val Phe Gln Glu Asp Pro Asn Ser Asp Pro Gln 
         275                280                285
Gln Pro Thr Phe Ser Leu Thr Ala His Leu His Gln Ala His Ser Gln 
     290                295                300
Asp Val Asn Cys Val Ala Trp Asn Pro Lys Glu Pro Gly Leu Leu Ala 
 305                310                315                320
Ser Cys Ser Asp Asp Gly Glu Val Ala Phe Trp Lys Tyr Gln Arg Pro 
                 325                330                335
Glu Gly Leu 
             340



<210> 5590
<211> 686
<212> DNA
<213> Rattus norvegicus
<308> AA891829
<400> 5590

atattttat  aatatattt  cccccaaaa  gtaacacct  ccctaaatc  agcaaaact  60
taatattta  tattaaata  taaatattt  atattctgc  gttccgtgg  tctgtccaa  120
ggctttctc  catcaaggg  aacagtgaa  ggtcctgag  taaatgaaa  tcaaggatg  180
ttcaggtct  ctcagtgac  aggaaaagt  ttaggacat  ttctgtggg  atcaagatc  240
ccaagtcaa  ctgcagctc  gagacctgc  ggctgatga  actcccaga  ggctacctc  300
ccatcatca  tacaagagg  caggagccc  gcctccttg  ggttccaag  cacacagtt  360
acatcctgg  aatgggcct  acgaagatg  gctgtcaaa  agaaggtgg  ctgctgtgg  420
tctgagcct  gatcttcct  aaacactcg  atggcatca  ctccacaag  tgtagccag  480
gcccctgtc  gctgacacc  agcaacgtc  tagatggtc  tggtatgga  gcccgacaa  540
gtgcaaaca  atttccagc  ggggtcgga  ccactgcat  ccacccctt  ttcattgcc  600
ggtagatac  ggcgccaga  gcgcacagt  cggtcatca  tgcaagatg  cagacgctg  660
ncgctggga  caaaggcta  gctcca  686



<210> 5591
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> P22288
<400> 5591

Met Glu Lys Pro Arg Gly Val Arg Cys Thr Asn Gly Phe Pro Glu Arg 
  1               5                  10                  15
Glu Leu Pro Arg Pro Gly Ala Ser Arg Pro Ala Glu Lys Ser Arg Pro 
             20                  25                  30
Pro Glu Ala Lys Gly Ala Gln Pro Ala Asp Ala Trp Lys Ala Gly Arg 
         35                  40                  45
Pro Arg Ser Glu Glu Asp Asn Glu Leu Asn Leu Pro Asn Leu Ala Ala 
     50                  55                  60
Ala Tyr Ser Ser Ile Leu Arg Ser Leu Gly Glu Asp Pro Gln Arg Gln 
 65                  70                  75                  80
Gly Leu Leu Lys Thr Pro Trp Arg Ala Ala Thr Ala Met Gln Phe Phe 
                 85                  90                  95
Thr Lys Gly Tyr Gln Glu Thr Ile Ser Asp Val Leu Asn Asp Ala Ile 
             100                105                110
Phe Asp Glu Asp His Asp Glu Met Val Ile Val Lys Asp Ile Asp Met 
         115                120                125
Phe Ser Met Cys Glu His His Leu Val Pro Phe Val Gly Arg Val His 
     130                135                140
Ile Gly Tyr Leu Pro Asn Lys Gln Val Leu Gly Leu Ser Lys Leu Ala 
 145                150                155                160
Arg Ile Val Glu Ile Tyr Ser Arg Arg Leu Gln Val Gln Glu Arg Leu 
                 165                170                175
Thr Lys Gln Ile Ala Val Ala Ile Thr Glu Ala Leu Gln Pro Ala Gly 
             180                185                190
Val Gly Val Val Ile Glu Ala Thr His Met Cys Met Val Met Arg Gly 
         195                200                205
Val Gln Lys Met Asn Ser Lys Thr Val Thr Ser Thr Met Leu Gly Val 
     210                215                220
Phe Arg Glu Asp Pro Lys Thr Arg Glu Glu Phe Leu Thr Leu Ile Arg 
 225                230                235                240
Ser 
                 245



<210> 5592
<211> 1413
<212> DNA
<213> Homo sapiens
<308> U63810
<400> 5592

ggtgagttt  cggggcgac  caggtcctc  ggcggaacg  ggagcctct  tcggccgcg  60
aagcctgga  tgggcggta  gcagacgcg  gcggcgaga  ccgctgtct  ctcagcgga  120
tctgcccgc  cccacctcc  cctgcgtcg  gccgacatg  aggactcgc  ggtgctgct  180
ggccgtgtc  cggcgcacc  ggactcccg  tgctggttc  tggcctgga  ccccgcggg  240
accctgctg  cctcgtgcg  cggcgaccg  agaatccgc  tctggggca  ggagggtga  300
agctggatc  gcaagtctg  cctttctga  ggccaccag  gcaccgtgc  gaaggtagc  360
tggtccccc  gcggtaatt  cctggcctc  gccagcttt  atgctacca  ttgcatttg  420
aagaagaac  aggatgact  tgagtgtgt  accactctc  agggccatg  aaatgaggt  480
aagtcagtg  cttgggccc  atctggcaa  ctcctggcc  cttgcagcc  agataagag  540
gtttgggtc  gggaagttg  tgaagagga  gagtatgaa  gtgtcagtg  tctcaactc  600
cacacacag  atgtcaagc  tgtggtttg  cacccaagt  aggagctct  agcttctgc  660
agctatgat  acacagtga  gctgtaccg  gaggaagag  atgactggg  atgctgtgc  720
acccttgag  gccatgaat  cactgtgtg  agcttggcc  ttgacccga  tggccagcg  780
ctggcgtct  gtagtgatg  ccgtactgt  cgtatctgg  gtcagtatc  accaggcaa  840
gaacaaggg  tggcatgca  cggctctga  cccagttgg  aatgtatct  tactttgtc  900
ggcttccac  caaggacca  ttatgacat  gcttggtgt  agctgacag  ggctctggc  960
acagcttgt  gggatgacg  gatccgcgt  tttcaggag  atcccaact  ggatccaca  1020
cagcccacc  tctccctga  agcccactt  catcaggcc  attcccagg  tgtcaactg  1080
gtggcctgg  accccaagg  gccagggct  ctggcctcc  gcagtgatg  tggggaggt  1140
gccttctgg  agtatcagc  gcctgaagg  ctctgagct  ccacgtctt  ggacagagt  1200
atgactccc  agaaaacgt  atataagac  tttaccagc  cctgagagg  ccaggagga  1260
catccttga  cttcattta  cttggctca  ttctcttca  acttgggta  aagtgcaga  1320
ccacagaat  gctttcctt  cccgccttt  acatgaggc  ttcagtaaa  agctacaga  1380
catgaaaaa  aaaaaaaaa  aaaaaaaaa  aaa  1413



<210> 5593
<211> 339
<212> PRT
<213> Homo sapiens
<308> O76071
<400> 5593

Met Lys Asp Ser Leu Val Leu Leu Gly Arg Val Pro Ala His Pro Asp 
  1               5                  10                  15
Ser Arg Cys Trp Phe Leu Ala Trp Asn Pro Ala Gly Thr Leu Leu Ala 
             20                  25                  30
Ser Cys Gly Gly Asp Arg Arg Ile Arg Ile Trp Gly Thr Glu Gly Asp 
         35                  40                  45
Ser Trp Ile Cys Lys Ser Val Leu Ser Glu Gly His Gln Arg Thr Val 
     50                  55                  60
Arg Lys Val Ala Trp Ser Pro Cys Gly Asn Tyr Leu Ala Ser Ala Ser 
 65                  70                  75                  80
Phe Asp Ala Thr Thr Cys Ile Trp Lys Lys Asn Gln Asp Asp Phe Glu 
                 85                  90                  95
Cys Val Thr Thr Leu Glu Gly His Glu Asn Glu Val Lys Ser Val Ala 
             100                105                110
Trp Ala Pro Ser Gly Asn Leu Leu Ala Thr Cys Ser Arg Asp Lys Ser 
         115                120                125
Val Trp Val Trp Glu Val Asp Glu Glu Asp Glu Tyr Glu Cys Val Ser 
     130                135                140
Val Leu Asn Ser His Thr Gln Asp Val Lys His Val Val Trp His Pro 
 145                150                155                160
Ser Gln Glu Leu Leu Ala Ser Ala Ser Tyr Asp Asp Thr Val Lys Leu 
                 165                170                175
Tyr Arg Glu Glu Glu Asp Asp Trp Val Cys Cys Ala Thr Leu Glu Gly 
             180                185                190
His Glu Ser Thr Val Trp Ser Leu Ala Phe Asp Pro Ser Gly Gln Arg 
         195                200                205
Leu Ala Ser Cys Ser Asp Asp Arg Thr Val Arg Ile Trp Arg Gln Tyr 
     210                215                220
Leu Pro Gly Asn Glu Gln Gly Val Ala Cys Ser Gly Ser Asp Pro Ser 
 225                230                235                240
Trp Lys Cys Ile Cys Thr Leu Ser Gly Phe His Ser Arg Thr Ile Tyr 
                 245                250                255
Asp Ile Ala Trp Cys Gln Leu Thr Gly Ala Leu Ala Thr Ala Cys Gly 
             260                265                270
Asp Asp Ala Ile Arg Val Phe Gln Glu Asp Pro Asn Ser Asp Pro Gln 
         275                280                285
Gln Pro Thr Phe Ser Leu Thr Ala His Leu His Gln Ala His Ser Gln 
     290                295                300
Asp Val Asn Cys Val Ala Trp Asn Pro Lys Glu Pro Gly Leu Leu Ala 
 305                310                315                320
Ser Cys Ser Asp Asp Gly Glu Val Ala Phe Trp Lys Tyr Gln Arg Pro 
                 325                330                335
Glu Gly Leu 
             340



<210> 5594
<211> 686
<212> DNA
<213> Rattus norvegicus
<308> AA891829
<400> 5594

atattttat  aatatattt  cccccaaaa  gtaacacct  ccctaaatc  agcaaaact  60
taatattta  tattaaata  taaatattt  atattctgc  gttccgtgg  tctgtccaa  120
ggctttctc  catcaaggg  aacagtgaa  ggtcctgag  taaatgaaa  tcaaggatg  180
ttcaggtct  ctcagtgac  aggaaaagt  ttaggacat  ttctgtggg  atcaagatc  240
ccaagtcaa  ctgcagctc  gagacctgc  ggctgatga  actcccaga  ggctacctc  300
ccatcatca  tacaagagg  caggagccc  gcctccttg  ggttccaag  cacacagtt  360
acatcctgg  aatgggcct  acgaagatg  gctgtcaaa  agaaggtgg  ctgctgtgg  420
tctgagcct  gatcttcct  aaacactcg  atggcatca  ctccacaag  tgtagccag  480
gcccctgtc  gctgacacc  agcaacgtc  tagatggtc  tggtatgga  gcccgacaa  540
gtgcaaaca  atttccagc  ggggtcgga  ccactgcat  ccacccctt  ttcattgcc  600
ggtagatac  ggcgccaga  gcgcacagt  cggtcatca  tgcaagatg  cagacgctg  660
ncgctggga  caaaggcta  gctcca  686



<210> 5595
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> P22288
<400> 5595

Met Glu Lys Pro Arg Gly Val Arg Cys Thr Asn Gly Phe Pro Glu Arg 
  1               5                  10                  15
Glu Leu Pro Arg Pro Gly Ala Ser Arg Pro Ala Glu Lys Ser Arg Pro 
             20                  25                  30
Pro Glu Ala Lys Gly Ala Gln Pro Ala Asp Ala Trp Lys Ala Gly Arg 
         35                  40                  45
Pro Arg Ser Glu Glu Asp Asn Glu Leu Asn Leu Pro Asn Leu Ala Ala 
     50                  55                  60
Ala Tyr Ser Ser Ile Leu Arg Ser Leu Gly Glu Asp Pro Gln Arg Gln 
 65                  70                  75                  80
Gly Leu Leu Lys Thr Pro Trp Arg Ala Ala Thr Ala Met Gln Phe Phe 
                 85                  90                  95
Thr Lys Gly Tyr Gln Glu Thr Ile Ser Asp Val Leu Asn Asp Ala Ile 
             100                105                110
Phe Asp Glu Asp His Asp Glu Met Val Ile Val Lys Asp Ile Asp Met 
         115                120                125
Phe Ser Met Cys Glu His His Leu Val Pro Phe Val Gly Arg Val His 
     130                135                140
Ile Gly Tyr Leu Pro Asn Lys Gln Val Leu Gly Leu Ser Lys Leu Ala 
 145                150                155                160
Arg Ile Val Glu Ile Tyr Ser Arg Arg Leu Gln Val Gln Glu Arg Leu 
                 165                170                175
Thr Lys Gln Ile Ala Val Ala Ile Thr Glu Ala Leu Gln Pro Ala Gly 
             180                185                190
Val Gly Val Val Ile Glu Ala Thr His Met Cys Met Val Met Arg Gly 
         195                200                205
Val Gln Lys Met Asn Ser Lys Thr Val Thr Ser Thr Met Leu Gly Val 
     210                215                220
Phe Arg Glu Asp Pro Lys Thr Arg Glu Glu Phe Leu Thr Leu Ile Arg 
 225                230                235                240
Ser 
                 245



<210> 5596
<211> 1413
<212> DNA
<213> Homo sapiens
<308> U63810
<400> 5596

ggtgagttt  cggggcgac  caggtcctc  ggcggaacg  ggagcctct  tcggccgcg  60
aagcctgga  tgggcggta  gcagacgcg  gcggcgaga  ccgctgtct  ctcagcgga  120
tctgcccgc  cccacctcc  cctgcgtcg  gccgacatg  aggactcgc  ggtgctgct  180
ggccgtgtc  cggcgcacc  ggactcccg  tgctggttc  tggcctgga  ccccgcggg  240
accctgctg  cctcgtgcg  cggcgaccg  agaatccgc  tctggggca  ggagggtga  300
agctggatc  gcaagtctg  cctttctga  ggccaccag  gcaccgtgc  gaaggtagc  360
tggtccccc  gcggtaatt  cctggcctc  gccagcttt  atgctacca  ttgcatttg  420
aagaagaac  aggatgact  tgagtgtgt  accactctc  agggccatg  aaatgaggt  480
aagtcagtg  cttgggccc  atctggcaa  ctcctggcc  cttgcagcc  agataagag  540
gtttgggtc  gggaagttg  tgaagagga  gagtatgaa  gtgtcagtg  tctcaactc  600
cacacacag  atgtcaagc  tgtggtttg  cacccaagt  aggagctct  agcttctgc  660
agctatgat  acacagtga  gctgtaccg  gaggaagag  atgactggg  atgctgtgc  720
acccttgag  gccatgaat  cactgtgtg  agcttggcc  ttgacccga  tggccagcg  780
ctggcgtct  gtagtgatg  ccgtactgt  cgtatctgg  gtcagtatc  accaggcaa  840
gaacaaggg  tggcatgca  cggctctga  cccagttgg  aatgtatct  tactttgtc  900
ggcttccac  caaggacca  ttatgacat  gcttggtgt  agctgacag  ggctctggc  960
acagcttgt  gggatgacg  gatccgcgt  tttcaggag  atcccaact  ggatccaca  1020
cagcccacc  tctccctga  agcccactt  catcaggcc  attcccagg  tgtcaactg  1080
gtggcctgg  accccaagg  gccagggct  ctggcctcc  gcagtgatg  tggggaggt  1140
gccttctgg  agtatcagc  gcctgaagg  ctctgagct  ccacgtctt  ggacagagt  1200
atgactccc  agaaaacgt  atataagac  tttaccagc  cctgagagg  ccaggagga  1260
catccttga  cttcattta  cttggctca  ttctcttca  acttgggta  aagtgcaga  1320
ccacagaat  gctttcctt  cccgccttt  acatgaggc  ttcagtaaa  agctacaga  1380
catgaaaaa  aaaaaaaaa  aaaaaaaaa  aaa  1413



<210> 5597
<211> 339
<212> PRT
<213> Homo sapiens
<308> O76071
<400> 5597

Met Lys Asp Ser Leu Val Leu Leu Gly Arg Val Pro Ala His Pro Asp 
  1               5                  10                  15
Ser Arg Cys Trp Phe Leu Ala Trp Asn Pro Ala Gly Thr Leu Leu Ala 
             20                  25                  30
Ser Cys Gly Gly Asp Arg Arg Ile Arg Ile Trp Gly Thr Glu Gly Asp 
         35                  40                  45
Ser Trp Ile Cys Lys Ser Val Leu Ser Glu Gly His Gln Arg Thr Val 
     50                  55                  60
Arg Lys Val Ala Trp Ser Pro Cys Gly Asn Tyr Leu Ala Ser Ala Ser 
 65                  70                  75                  80
Phe Asp Ala Thr Thr Cys Ile Trp Lys Lys Asn Gln Asp Asp Phe Glu 
                 85                  90                  95
Cys Val Thr Thr Leu Glu Gly His Glu Asn Glu Val Lys Ser Val Ala 
             100                105                110
Trp Ala Pro Ser Gly Asn Leu Leu Ala Thr Cys Ser Arg Asp Lys Ser 
         115                120                125
Val Trp Val Trp Glu Val Asp Glu Glu Asp Glu Tyr Glu Cys Val Ser 
     130                135                140
Val Leu Asn Ser His Thr Gln Asp Val Lys His Val Val Trp His Pro 
 145                150                155                160
Ser Gln Glu Leu Leu Ala Ser Ala Ser Tyr Asp Asp Thr Val Lys Leu 
                 165                170                175
Tyr Arg Glu Glu Glu Asp Asp Trp Val Cys Cys Ala Thr Leu Glu Gly 
             180                185                190
His Glu Ser Thr Val Trp Ser Leu Ala Phe Asp Pro Ser Gly Gln Arg 
         195                200                205
Leu Ala Ser Cys Ser Asp Asp Arg Thr Val Arg Ile Trp Arg Gln Tyr 
     210                215                220
Leu Pro Gly Asn Glu Gln Gly Val Ala Cys Ser Gly Ser Asp Pro Ser 
 225                230                235                240
Trp Lys Cys Ile Cys Thr Leu Ser Gly Phe His Ser Arg Thr Ile Tyr 
                 245                250                255
Asp Ile Ala Trp Cys Gln Leu Thr Gly Ala Leu Ala Thr Ala Cys Gly 
             260                265                270
Asp Asp Ala Ile Arg Val Phe Gln Glu Asp Pro Asn Ser Asp Pro Gln 
         275                280                285
Gln Pro Thr Phe Ser Leu Thr Ala His Leu His Gln Ala His Ser Gln 
     290                295                300
Asp Val Asn Cys Val Ala Trp Asn Pro Lys Glu Pro Gly Leu Leu Ala 
 305                310                315                320
Ser Cys Ser Asp Asp Gly Glu Val Ala Phe Trp Lys Tyr Gln Arg Pro 
                 325                330                335
Glu Gly Leu 
             340



<210> 5598
<211> 686
<212> DNA
<213> Rattus norvegicus
<308> AA891829
<400> 5598

atattttat  aatatattt  cccccaaaa  gtaacacct  ccctaaatc  agcaaaact  60
taatattta  tattaaata  taaatattt  atattctgc  gttccgtgg  tctgtccaa  120
ggctttctc  catcaaggg  aacagtgaa  ggtcctgag  taaatgaaa  tcaaggatg  180
ttcaggtct  ctcagtgac  aggaaaagt  ttaggacat  ttctgtggg  atcaagatc  240
ccaagtcaa  ctgcagctc  gagacctgc  ggctgatga  actcccaga  ggctacctc  300
ccatcatca  tacaagagg  caggagccc  gcctccttg  ggttccaag  cacacagtt  360
acatcctgg  aatgggcct  acgaagatg  gctgtcaaa  agaaggtgg  ctgctgtgg  420
tctgagcct  gatcttcct  aaacactcg  atggcatca  ctccacaag  tgtagccag  480
gcccctgtc  gctgacacc  agcaacgtc  tagatggtc  tggtatgga  gcccgacaa  540
gtgcaaaca  atttccagc  ggggtcgga  ccactgcat  ccacccctt  ttcattgcc  600
ggtagatac  ggcgccaga  gcgcacagt  cggtcatca  tgcaagatg  cagacgctg  660
ncgctggga  caaaggcta  gctcca  686



<210> 5599
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> P22288
<400> 5599

Met Glu Lys Pro Arg Gly Val Arg Cys Thr Asn Gly Phe Pro Glu Arg 
  1               5                  10                  15
Glu Leu Pro Arg Pro Gly Ala Ser Arg Pro Ala Glu Lys Ser Arg Pro 
             20                  25                  30
Pro Glu Ala Lys Gly Ala Gln Pro Ala Asp Ala Trp Lys Ala Gly Arg 
         35                  40                  45
Pro Arg Ser Glu Glu Asp Asn Glu Leu Asn Leu Pro Asn Leu Ala Ala 
     50                  55                  60
Ala Tyr Ser Ser Ile Leu Arg Ser Leu Gly Glu Asp Pro Gln Arg Gln 
 65                  70                  75                  80
Gly Leu Leu Lys Thr Pro Trp Arg Ala Ala Thr Ala Met Gln Phe Phe 
                 85                  90                  95
Thr Lys Gly Tyr Gln Glu Thr Ile Ser Asp Val Leu Asn Asp Ala Ile 
             100                105                110
Phe Asp Glu Asp His Asp Glu Met Val Ile Val Lys Asp Ile Asp Met 
         115                120                125
Phe Ser Met Cys Glu His His Leu Val Pro Phe Val Gly Arg Val His 
     130                135                140
Ile Gly Tyr Leu Pro Asn Lys Gln Val Leu Gly Leu Ser Lys Leu Ala 
 145                150                155                160
Arg Ile Val Glu Ile Tyr Ser Arg Arg Leu Gln Val Gln Glu Arg Leu 
                 165                170                175
Thr Lys Gln Ile Ala Val Ala Ile Thr Glu Ala Leu Gln Pro Ala Gly 
             180                185                190
Val Gly Val Val Ile Glu Ala Thr His Met Cys Met Val Met Arg Gly 
         195                200                205
Val Gln Lys Met Asn Ser Lys Thr Val Thr Ser Thr Met Leu Gly Val 
     210                215                220
Phe Arg Glu Asp Pro Lys Thr Arg Glu Glu Phe Leu Thr Leu Ile Arg 
 225                230                235                240
Ser 
                 245



<210> 5600
<211> 1413
<212> DNA
<213> Homo sapiens
<308> U63810
<400> 5600

ggtgagttt  cggggcgac  caggtcctc  ggcggaacg  ggagcctct  tcggccgcg  60
aagcctgga  tgggcggta  gcagacgcg  gcggcgaga  ccgctgtct  ctcagcgga  120
tctgcccgc  cccacctcc  cctgcgtcg  gccgacatg  aggactcgc  ggtgctgct  180
ggccgtgtc  cggcgcacc  ggactcccg  tgctggttc  tggcctgga  ccccgcggg  240
accctgctg  cctcgtgcg  cggcgaccg  agaatccgc  tctggggca  ggagggtga  300
agctggatc  gcaagtctg  cctttctga  ggccaccag  gcaccgtgc  gaaggtagc  360
tggtccccc  gcggtaatt  cctggcctc  gccagcttt  atgctacca  ttgcatttg  420
aagaagaac  aggatgact  tgagtgtgt  accactctc  agggccatg  aaatgaggt  480
aagtcagtg  cttgggccc  atctggcaa  ctcctggcc  cttgcagcc  agataagag  540
gtttgggtc  gggaagttg  tgaagagga  gagtatgaa  gtgtcagtg  tctcaactc  600
cacacacag  atgtcaagc  tgtggtttg  cacccaagt  aggagctct  agcttctgc  660
agctatgat  acacagtga  gctgtaccg  gaggaagag  atgactggg  atgctgtgc  720
acccttgag  gccatgaat  cactgtgtg  agcttggcc  ttgacccga  tggccagcg  780
ctggcgtct  gtagtgatg  ccgtactgt  cgtatctgg  gtcagtatc  accaggcaa  840
gaacaaggg  tggcatgca  cggctctga  cccagttgg  aatgtatct  tactttgtc  900
ggcttccac  caaggacca  ttatgacat  gcttggtgt  agctgacag  ggctctggc  960
acagcttgt  gggatgacg  gatccgcgt  tttcaggag  atcccaact  ggatccaca  1020
cagcccacc  tctccctga  agcccactt  catcaggcc  attcccagg  tgtcaactg  1080
gtggcctgg  accccaagg  gccagggct  ctggcctcc  gcagtgatg  tggggaggt  1140
gccttctgg  agtatcagc  gcctgaagg  ctctgagct  ccacgtctt  ggacagagt  1200
atgactccc  agaaaacgt  atataagac  tttaccagc  cctgagagg  ccaggagga  1260
catccttga  cttcattta  cttggctca  ttctcttca  acttgggta  aagtgcaga  1320
ccacagaat  gctttcctt  cccgccttt  acatgaggc  ttcagtaaa  agctacaga  1380
catgaaaaa  aaaaaaaaa  aaaaaaaaa  aaa  1413



<210> 5601
<211> 339
<212> PRT
<213> Homo sapiens
<308> O76071
<400> 5601

Met Lys Asp Ser Leu Val Leu Leu Gly Arg Val Pro Ala His Pro Asp 
  1               5                  10                  15
Ser Arg Cys Trp Phe Leu Ala Trp Asn Pro Ala Gly Thr Leu Leu Ala 
             20                  25                  30
Ser Cys Gly Gly Asp Arg Arg Ile Arg Ile Trp Gly Thr Glu Gly Asp 
         35                  40                  45
Ser Trp Ile Cys Lys Ser Val Leu Ser Glu Gly His Gln Arg Thr Val 
     50                  55                  60
Arg Lys Val Ala Trp Ser Pro Cys Gly Asn Tyr Leu Ala Ser Ala Ser 
 65                  70                  75                  80
Phe Asp Ala Thr Thr Cys Ile Trp Lys Lys Asn Gln Asp Asp Phe Glu 
                 85                  90                  95
Cys Val Thr Thr Leu Glu Gly His Glu Asn Glu Val Lys Ser Val Ala 
             100                105                110
Trp Ala Pro Ser Gly Asn Leu Leu Ala Thr Cys Ser Arg Asp Lys Ser 
         115                120                125
Val Trp Val Trp Glu Val Asp Glu Glu Asp Glu Tyr Glu Cys Val Ser 
     130                135                140
Val Leu Asn Ser His Thr Gln Asp Val Lys His Val Val Trp His Pro 
 145                150                155                160
Ser Gln Glu Leu Leu Ala Ser Ala Ser Tyr Asp Asp Thr Val Lys Leu 
                 165                170                175
Tyr Arg Glu Glu Glu Asp Asp Trp Val Cys Cys Ala Thr Leu Glu Gly 
             180                185                190
His Glu Ser Thr Val Trp Ser Leu Ala Phe Asp Pro Ser Gly Gln Arg 
         195                200                205
Leu Ala Ser Cys Ser Asp Asp Arg Thr Val Arg Ile Trp Arg Gln Tyr 
     210                215                220
Leu Pro Gly Asn Glu Gln Gly Val Ala Cys Ser Gly Ser Asp Pro Ser 
 225                230                235                240
Trp Lys Cys Ile Cys Thr Leu Ser Gly Phe His Ser Arg Thr Ile Tyr 
                 245                250                255
Asp Ile Ala Trp Cys Gln Leu Thr Gly Ala Leu Ala Thr Ala Cys Gly 
             260                265                270
Asp Asp Ala Ile Arg Val Phe Gln Glu Asp Pro Asn Ser Asp Pro Gln 
         275                280                285
Gln Pro Thr Phe Ser Leu Thr Ala His Leu His Gln Ala His Ser Gln 
     290                295                300
Asp Val Asn Cys Val Ala Trp Asn Pro Lys Glu Pro Gly Leu Leu Ala 
 305                310                315                320
Ser Cys Ser Asp Asp Gly Glu Val Ala Phe Trp Lys Tyr Gln Arg Pro 
                 325                330                335
Glu Gly Leu 
             340



<210> 5602
<211> 686
<212> DNA
<213> Rattus norvegicus
<308> AA891829
<400> 5602

atattttat  aatatattt  cccccaaaa  gtaacacct  ccctaaatc  agcaaaact  60
taatattta  tattaaata  taaatattt  atattctgc  gttccgtgg  tctgtccaa  120
ggctttctc  catcaaggg  aacagtgaa  ggtcctgag  taaatgaaa  tcaaggatg  180
ttcaggtct  ctcagtgac  aggaaaagt  ttaggacat  ttctgtggg  atcaagatc  240
ccaagtcaa  ctgcagctc  gagacctgc  ggctgatga  actcccaga  ggctacctc  300
ccatcatca  tacaagagg  caggagccc  gcctccttg  ggttccaag  cacacagtt  360
acatcctgg  aatgggcct  acgaagatg  gctgtcaaa  agaaggtgg  ctgctgtgg  420
tctgagcct  gatcttcct  aaacactcg  atggcatca  ctccacaag  tgtagccag  480
gcccctgtc  gctgacacc  agcaacgtc  tagatggtc  tggtatgga  gcccgacaa  540
gtgcaaaca  atttccagc  ggggtcgga  ccactgcat  ccacccctt  ttcattgcc  600
ggtagatac  ggcgccaga  gcgcacagt  cggtcatca  tgcaagatg  cagacgctg  660
ncgctggga  caaaggcta  gctcca  686



<210> 5603
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> P22288
<400> 5603

Met Glu Lys Pro Arg Gly Val Arg Cys Thr Asn Gly Phe Pro Glu Arg 
  1               5                  10                  15
Glu Leu Pro Arg Pro Gly Ala Ser Arg Pro Ala Glu Lys Ser Arg Pro 
             20                  25                  30
Pro Glu Ala Lys Gly Ala Gln Pro Ala Asp Ala Trp Lys Ala Gly Arg 
         35                  40                  45
Pro Arg Ser Glu Glu Asp Asn Glu Leu Asn Leu Pro Asn Leu Ala Ala 
     50                  55                  60
Ala Tyr Ser Ser Ile Leu Arg Ser Leu Gly Glu Asp Pro Gln Arg Gln 
 65                  70                  75                  80
Gly Leu Leu Lys Thr Pro Trp Arg Ala Ala Thr Ala Met Gln Phe Phe 
                 85                  90                  95
Thr Lys Gly Tyr Gln Glu Thr Ile Ser Asp Val Leu Asn Asp Ala Ile 
             100                105                110
Phe Asp Glu Asp His Asp Glu Met Val Ile Val Lys Asp Ile Asp Met 
         115                120                125
Phe Ser Met Cys Glu His His Leu Val Pro Phe Val Gly Arg Val His 
     130                135                140
Ile Gly Tyr Leu Pro Asn Lys Gln Val Leu Gly Leu Ser Lys Leu Ala 
 145                150                155                160
Arg Ile Val Glu Ile Tyr Ser Arg Arg Leu Gln Val Gln Glu Arg Leu 
                 165                170                175
Thr Lys Gln Ile Ala Val Ala Ile Thr Glu Ala Leu Gln Pro Ala Gly 
             180                185                190
Val Gly Val Val Ile Glu Ala Thr His Met Cys Met Val Met Arg Gly 
         195                200                205
Val Gln Lys Met Asn Ser Lys Thr Val Thr Ser Thr Met Leu Gly Val 
     210                215                220
Phe Arg Glu Asp Pro Lys Thr Arg Glu Glu Phe Leu Thr Leu Ile Arg 
 225                230                235                240
Ser 
                 245



<210> 5604
<211> 1413
<212> DNA
<213> Homo sapiens
<308> U63810
<400> 5604

ggtgagttt  cggggcgac  caggtcctc  ggcggaacg  ggagcctct  tcggccgcg  60
aagcctgga  tgggcggta  gcagacgcg  gcggcgaga  ccgctgtct  ctcagcgga  120
tctgcccgc  cccacctcc  cctgcgtcg  gccgacatg  aggactcgc  ggtgctgct  180
ggccgtgtc  cggcgcacc  ggactcccg  tgctggttc  tggcctgga  ccccgcggg  240
accctgctg  cctcgtgcg  cggcgaccg  agaatccgc  tctggggca  ggagggtga  300
agctggatc  gcaagtctg  cctttctga  ggccaccag  gcaccgtgc  gaaggtagc  360
tggtccccc  gcggtaatt  cctggcctc  gccagcttt  atgctacca  ttgcatttg  420
aagaagaac  aggatgact  tgagtgtgt  accactctc  agggccatg  aaatgaggt  480
aagtcagtg  cttgggccc  atctggcaa  ctcctggcc  cttgcagcc  agataagag  540
gtttgggtc  gggaagttg  tgaagagga  gagtatgaa  gtgtcagtg  tctcaactc  600
cacacacag  atgtcaagc  tgtggtttg  cacccaagt  aggagctct  agcttctgc  660
agctatgat  acacagtga  gctgtaccg  gaggaagag  atgactggg  atgctgtgc  720
acccttgag  gccatgaat  cactgtgtg  agcttggcc  ttgacccga  tggccagcg  780
ctggcgtct  gtagtgatg  ccgtactgt  cgtatctgg  gtcagtatc  accaggcaa  840
gaacaaggg  tggcatgca  cggctctga  cccagttgg  aatgtatct  tactttgtc  900
ggcttccac  caaggacca  ttatgacat  gcttggtgt  agctgacag  ggctctggc  960
acagcttgt  gggatgacg  gatccgcgt  tttcaggag  atcccaact  ggatccaca  1020
cagcccacc  tctccctga  agcccactt  catcaggcc  attcccagg  tgtcaactg  1080
gtggcctgg  accccaagg  gccagggct  ctggcctcc  gcagtgatg  tggggaggt  1140
gccttctgg  agtatcagc  gcctgaagg  ctctgagct  ccacgtctt  ggacagagt  1200
atgactccc  agaaaacgt  atataagac  tttaccagc  cctgagagg  ccaggagga  1260
catccttga  cttcattta  cttggctca  ttctcttca  acttgggta  aagtgcaga  1320
ccacagaat  gctttcctt  cccgccttt  acatgaggc  ttcagtaaa  agctacaga  1380
catgaaaaa  aaaaaaaaa  aaaaaaaaa  aaa  1413



<210> 5605
<211> 339
<212> PRT
<213> Homo sapiens
<308> O76071
<400> 5605

Met Lys Asp Ser Leu Val Leu Leu Gly Arg Val Pro Ala His Pro Asp 
  1               5                  10                  15
Ser Arg Cys Trp Phe Leu Ala Trp Asn Pro Ala Gly Thr Leu Leu Ala 
             20                  25                  30
Ser Cys Gly Gly Asp Arg Arg Ile Arg Ile Trp Gly Thr Glu Gly Asp 
         35                  40                  45
Ser Trp Ile Cys Lys Ser Val Leu Ser Glu Gly His Gln Arg Thr Val 
     50                  55                  60
Arg Lys Val Ala Trp Ser Pro Cys Gly Asn Tyr Leu Ala Ser Ala Ser 
 65                  70                  75                  80
Phe Asp Ala Thr Thr Cys Ile Trp Lys Lys Asn Gln Asp Asp Phe Glu 
                 85                  90                  95
Cys Val Thr Thr Leu Glu Gly His Glu Asn Glu Val Lys Ser Val Ala 
             100                105                110
Trp Ala Pro Ser Gly Asn Leu Leu Ala Thr Cys Ser Arg Asp Lys Ser 
         115                120                125
Val Trp Val Trp Glu Val Asp Glu Glu Asp Glu Tyr Glu Cys Val Ser 
     130                135                140
Val Leu Asn Ser His Thr Gln Asp Val Lys His Val Val Trp His Pro 
 145                150                155                160
Ser Gln Glu Leu Leu Ala Ser Ala Ser Tyr Asp Asp Thr Val Lys Leu 
                 165                170                175
Tyr Arg Glu Glu Glu Asp Asp Trp Val Cys Cys Ala Thr Leu Glu Gly 
             180                185                190
His Glu Ser Thr Val Trp Ser Leu Ala Phe Asp Pro Ser Gly Gln Arg 
         195                200                205
Leu Ala Ser Cys Ser Asp Asp Arg Thr Val Arg Ile Trp Arg Gln Tyr 
     210                215                220
Leu Pro Gly Asn Glu Gln Gly Val Ala Cys Ser Gly Ser Asp Pro Ser 
 225                230                235                240
Trp Lys Cys Ile Cys Thr Leu Ser Gly Phe His Ser Arg Thr Ile Tyr 
                 245                250                255
Asp Ile Ala Trp Cys Gln Leu Thr Gly Ala Leu Ala Thr Ala Cys Gly 
             260                265                270
Asp Asp Ala Ile Arg Val Phe Gln Glu Asp Pro Asn Ser Asp Pro Gln 
         275                280                285
Gln Pro Thr Phe Ser Leu Thr Ala His Leu His Gln Ala His Ser Gln 
     290                295                300
Asp Val Asn Cys Val Ala Trp Asn Pro Lys Glu Pro Gly Leu Leu Ala 
 305                310                315                320
Ser Cys Ser Asp Asp Gly Glu Val Ala Phe Trp Lys Tyr Gln Arg Pro 
                 325                330                335
Glu Gly Leu 
             340



<210> 5606
<211> 686
<212> DNA
<213> Rattus norvegicus
<308> AA891829
<400> 5606

atattttat  aatatattt  cccccaaaa  gtaacacct  ccctaaatc  agcaaaact  60
taatattta  tattaaata  taaatattt  atattctgc  gttccgtgg  tctgtccaa  120
ggctttctc  catcaaggg  aacagtgaa  ggtcctgag  taaatgaaa  tcaaggatg  180
ttcaggtct  ctcagtgac  aggaaaagt  ttaggacat  ttctgtggg  atcaagatc  240
ccaagtcaa  ctgcagctc  gagacctgc  ggctgatga  actcccaga  ggctacctc  300
ccatcatca  tacaagagg  caggagccc  gcctccttg  ggttccaag  cacacagtt  360
acatcctgg  aatgggcct  acgaagatg  gctgtcaaa  agaaggtgg  ctgctgtgg  420
tctgagcct  gatcttcct  aaacactcg  atggcatca  ctccacaag  tgtagccag  480
gcccctgtc  gctgacacc  agcaacgtc  tagatggtc  tggtatgga  gcccgacaa  540
gtgcaaaca  atttccagc  ggggtcgga  ccactgcat  ccacccctt  ttcattgcc  600
ggtagatac  ggcgccaga  gcgcacagt  cggtcatca  tgcaagatg  cagacgctg  660
ncgctggga  caaaggcta  gctcca  686



<210> 5607
<211> 241
<212> PRT
<213> Rattus norvegicus
<308> P22288
<400> 5607

Met Glu Lys Pro Arg Gly Val Arg Cys Thr Asn Gly Phe Pro Glu Arg 
  1               5                  10                  15
Glu Leu Pro Arg Pro Gly Ala Ser Arg Pro Ala Glu Lys Ser Arg Pro 
             20                  25                  30
Pro Glu Ala Lys Gly Ala Gln Pro Ala Asp Ala Trp Lys Ala Gly Arg 
         35                  40                  45
Pro Arg Ser Glu Glu Asp Asn Glu Leu Asn Leu Pro Asn Leu Ala Ala 
     50                  55                  60
Ala Tyr Ser Ser Ile Leu Arg Ser Leu Gly Glu Asp Pro Gln Arg Gln 
 65                  70                  75                  80
Gly Leu Leu Lys Thr Pro Trp Arg Ala Ala Thr Ala Met Gln Phe Phe 
                 85                  90                  95
Thr Lys Gly Tyr Gln Glu Thr Ile Ser Asp Val Leu Asn Asp Ala Ile 
             100                105                110
Phe Asp Glu Asp His Asp Glu Met Val Ile Val Lys Asp Ile Asp Met 
         115                120                125
Phe Ser Met Cys Glu His His Leu Val Pro Phe Val Gly Arg Val His 
     130                135                140
Ile Gly Tyr Leu Pro Asn Lys Gln Val Leu Gly Leu Ser Lys Leu Ala 
 145                150                155                160
Arg Ile Val Glu Ile Tyr Ser Arg Arg Leu Gln Val Gln Glu Arg Leu 
                 165                170                175
Thr Lys Gln Ile Ala Val Ala Ile Thr Glu Ala Leu Gln Pro Ala Gly 
             180                185                190
Val Gly Val Val Ile Glu Ala Thr His Met Cys Met Val Met Arg Gly 
         195                200                205
Val Gln Lys Met Asn Ser Lys Thr Val Thr Ser Thr Met Leu Gly Val 
     210                215                220
Phe Arg Glu Asp Pro Lys Thr Arg Glu Glu Phe Leu Thr Leu Ile Arg 
 225                230                235                240
Ser 
                 245



<210> 5608
<211> 1413
<212> DNA
<213> Homo sapiens
<308> U63810
<400> 5608

ggtgagttt  cggggcgac  caggtcctc  ggcggaacg  ggagcctct  tcggccgcg  60
aagcctgga  tgggcggta  gcagacgcg  gcggcgaga  ccgctgtct  ctcagcgga  120
tctgcccgc  cccacctcc  cctgcgtcg  gccgacatg  aggactcgc  ggtgctgct  180
ggccgtgtc  cggcgcacc  ggactcccg  tgctggttc  tggcctgga  ccccgcggg  240
accctgctg  cctcgtgcg  cggcgaccg  agaatccgc  tctggggca  ggagggtga  300
agctggatc  gcaagtctg  cctttctga  ggccaccag  gcaccgtgc  gaaggtagc  360
tggtccccc  gcggtaatt  cctggcctc  gccagcttt  atgctacca  ttgcatttg  420
aagaagaac  aggatgact  tgagtgtgt  accactctc  agggccatg  aaatgaggt  480
aagtcagtg  cttgggccc  atctggcaa  ctcctggcc  cttgcagcc  agataagag  540
gtttgggtc  gggaagttg  tgaagagga  gagtatgaa  gtgtcagtg  tctcaactc  600
cacacacag  atgtcaagc  tgtggtttg  cacccaagt  aggagctct  agcttctgc  660
agctatgat  acacagtga  gctgtaccg  gaggaagag  atgactggg  atgctgtgc  720
acccttgag  gccatgaat  cactgtgtg  agcttggcc  ttgacccga  tggccagcg  780
ctggcgtct  gtagtgatg  ccgtactgt  cgtatctgg  gtcagtatc  accaggcaa  840
gaacaaggg  tggcatgca  cggctctga  cccagttgg  aatgtatct  tactttgtc  900
ggcttccac  caaggacca  ttatgacat  gcttggtgt  agctgacag  ggctctggc  960
acagcttgt  gggatgacg  gatccgcgt  tttcaggag  atcccaact  ggatccaca  1020
cagcccacc  tctccctga  agcccactt  catcaggcc  attcccagg  tgtcaactg  1080
gtggcctgg  accccaagg  gccagggct  ctggcctcc  gcagtgatg  tggggaggt  1140
gccttctgg  agtatcagc  gcctgaagg  ctctgagct  ccacgtctt  ggacagagt  1200
atgactccc  agaaaacgt  atataagac  tttaccagc  cctgagagg  ccaggagga  1260
catccttga  cttcattta  cttggctca  ttctcttca  acttgggta  aagtgcaga  1320
ccacagaat  gctttcctt  cccgccttt  acatgaggc  ttcagtaaa  agctacaga  1380
catgaaaaa  aaaaaaaaa  aaaaaaaaa  aaa  1413



<210> 5609
<211> 339
<212> PRT
<213> Homo sapiens
<308> O76071
<400> 5609

Met Lys Asp Ser Leu Val Leu Leu Gly Arg Val Pro Ala His Pro Asp 
  1               5                  10                  15
Ser Arg Cys Trp Phe Leu Ala Trp Asn Pro Ala Gly Thr Leu Leu Ala 
             20                  25                  30
Ser Cys Gly Gly Asp Arg Arg Ile Arg Ile Trp Gly Thr Glu Gly Asp 
         35                  40                  45
Ser Trp Ile Cys Lys Ser Val Leu Ser Glu Gly His Gln Arg Thr Val 
     50                  55                  60
Arg Lys Val Ala Trp Ser Pro Cys Gly Asn Tyr Leu Ala Ser Ala Ser 
 65                  70                  75                  80
Phe Asp Ala Thr Thr Cys Ile Trp Lys Lys Asn Gln Asp Asp Phe Glu 
                 85                  90                  95
Cys Val Thr Thr Leu Glu Gly His Glu Asn Glu Val Lys Ser Val Ala 
             100                105                110
Trp Ala Pro Ser Gly Asn Leu Leu Ala Thr Cys Ser Arg Asp Lys Ser 
         115                120                125
Val Trp Val Trp Glu Val Asp Glu Glu Asp Glu Tyr Glu Cys Val Ser 
     130                135                140
Val Leu Asn Ser His Thr Gln Asp Val Lys His Val Val Trp His Pro 
 145                150                155                160
Ser Gln Glu Leu Leu Ala Ser Ala Ser Tyr Asp Asp Thr Val Lys Leu 
                 165                170                175
Tyr Arg Glu Glu Glu Asp Asp Trp Val Cys Cys Ala Thr Leu Glu Gly 
             180                185                190
His Glu Ser Thr Val Trp Ser Leu Ala Phe Asp Pro Ser Gly Gln Arg 
         195                200                205
Leu Ala Ser Cys Ser Asp Asp Arg Thr Val Arg Ile Trp Arg Gln Tyr 
     210                215                220
Leu Pro Gly Asn Glu Gln Gly Val Ala Cys Ser Gly Ser Asp Pro Ser 
 225                230                235                240
Trp Lys Cys Ile Cys Thr Leu Ser Gly Phe His Ser Arg Thr Ile Tyr 
                 245                250                255
Asp Ile Ala Trp Cys Gln Leu Thr Gly Ala Leu Ala Thr Ala Cys Gly 
             260                265                270
Asp Asp Ala Ile Arg Val Phe Gln Glu Asp Pro Asn Ser Asp Pro Gln 
         275                280                285
Gln Pro Thr Phe Ser Leu Thr Ala His Leu His Gln Ala His Ser Gln 
     290                295                300
Asp Val Asn Cys Val Ala Trp Asn Pro Lys Glu Pro Gly Leu Leu Ala 
 305                310                315                320
Ser Cys Ser Asp Asp Gly Glu Val Ala Phe Trp Lys Tyr Gln Arg Pro 
                 325                330                335
Glu Gly Leu 
             340



<210> 5610
<211> 591
<212> DNA
<213> Rattus norvegicus
<308> AA891842
<400> 5610

aacaaacac  taatattta  taataaatt  gtatacttg  aggcatttt  ctgatatca  60
ttcctcacc  ctaagccca  ccacacaaa  gcagtgggc  tctagctct  cattagagt  120
tgacaactg  gcatcagag  acaggttga  aaatgagag  gcgtagttg  aaatttatc  180
gacaggagt  cttacagct  cagccattt  taacgaaag  ggttggatg  caaaggaaa  240
ccagcaagg  cttgagggc  gactggacc  atagactat  tgtattgag  gagagagag  300
gagagagag  gagagagag  gagagagag  gagaggaat  aaaaaaata  gagaaatat  360
ttttaaagc  aagctgggc  taaagtggc  ttccaaggt  cagcaaagg  gttcctaaa  420
gatgaagat  gagttcttt  gcggcccag  tgtcaagcc  ctgaaacag  aagtcctgg  480
gacttaagg  tttcattct  cagcccaga  cttagcagc  ttaacggga  cacaagtta  540
aagcagtgt  cggtgtcca  acgagaacc  tacagcgag  gatagagag  g  591



<210> 5611
<211> 1101
<212> DNA
<213> Homo sapiens
<308> BC005192
<400> 5611

cttgagttc  ttctccttc  ctctctctc  ttttttttt  aataactct  ctgggaagt  60
ggtttataa  cctttgcca  gtgtaactg  tgtgaaata  ccaccacta  agttttttt  120
agttccata  tttctccat  ttgccttct  atgtatttt  aagattatt  tgtgcactt  180
aaatttact  aacttacca  aaatgcagt  tgacttttc  cacacactg  attgtgagg  240
tcttaactt  ttaaaagta  aatggcatc  tgtgaatcc  ataagcagt  tttatgtct  300
ttaacattc  cacctactt  ttaaaaaca  atattatta  tatttttat  attgtttgt  360
ctttataaa  tttcttaaa  attaagaaa  tttaagacc  cattgagtt  ctgtaatgc  420
attcaactt  gagttatct  ttaaatatg  cttgtatag  tcatattca  ggctgaaac  480
tgaccacac  attgctgat  gtatggttt  cacctggac  ccgtgtaga  tgcttgatt  540
cttgtactc  tcttatgct  atatgctct  ggctggaga  atgaaatcc  caagccatc  600
ggatttgct  tttaagtgg  ttgacaact  ggccaccaa  gaacttgaa  ttcaccttt  660
aggatttga  ctgttctgg  acacattgc  gcactttgg  aagtcaaaa  caagtgcca  720
tggcgccct  tccatagag  atttgccca  ctttgcttt  aaagatgtc  tgtttttta  780
atacacata  tcaataggt  caatctgct  tcaaggcct  ggtcctggt  ggattcctt  840
accaattac  ttaattaaa  atggctgca  ctgtaagaa  ccttgtctg  tatatttgc  900
actatgctc  catttacaa  tgtaccttc  aatgctcag  tgccaggtt  caatgcaaa  960
gtggcgtgg  ctccctttg  gtgggtggg  tttgtgggt  gtggtgaag  accgatatc  1020
gaaaaatgc  ttcaagtgt  ctaatttat  aataaacat  aggtgtttg  taaaaaaaa  1080
aaaaaaaaa  aaaaaaaaa  a  1101



<210> 5612
<211> 124
<212> PRT
<213> Homo sapiens
<308> AAF64274
<400> 5612

Met Gln Phe Asn Phe Glu Leu Ser Phe Lys Tyr Val Leu Tyr Ser Ser 
  1               5                  10                  15
Tyr Ser Trp Leu Lys Leu Asp His Thr Ile Ala Asp Cys Met Val Phe 
             20                  25                  30
Thr Trp Thr Pro Cys Arg Met Leu Asp Tyr Leu Tyr Ser Ser Tyr Ala 
         35                  40                  45
Asn Met Leu Trp Ala Gly Glu Met Lys Ser Ser Ser His Gln Asp Leu 
     50                  55                  60
Leu Phe Lys Trp Leu Asp Asn Trp Ala Thr Lys Glu Leu Glu Leu His 
 65                  70                  75                  80
Leu Leu Gly Phe Glu Leu Phe Trp Asn Thr Leu Leu His Phe Gly Lys 
                 85                  90                  95
Ser Lys Ser Ser Ala Ser Gly Ala Leu Ser Ile Glu Asn Leu Pro Ser 
             100                105                110
Phe Ala Leu Lys Asp Val Leu Phe Phe Ile Tyr Thr 
         115                120



<210> 5613
<211> 591
<212> DNA
<213> Rattus norvegicus
<308> AA891842
<400> 5613

aacaaacac  taatattta  taataaatt  gtatacttg  aggcatttt  ctgatatca  60
ttcctcacc  ctaagccca  ccacacaaa  gcagtgggc  tctagctct  cattagagt  120
tgacaactg  gcatcagag  acaggttga  aaatgagag  gcgtagttg  aaatttatc  180
gacaggagt  cttacagct  cagccattt  taacgaaag  ggttggatg  caaaggaaa  240
ccagcaagg  cttgagggc  gactggacc  atagactat  tgtattgag  gagagagag  300
gagagagag  gagagagag  gagagagag  gagaggaat  aaaaaaata  gagaaatat  360
ttttaaagc  aagctgggc  taaagtggc  ttccaaggt  cagcaaagg  gttcctaaa  420
gatgaagat  gagttcttt  gcggcccag  tgtcaagcc  ctgaaacag  aagtcctgg  480
gacttaagg  tttcattct  cagcccaga  cttagcagc  ttaacggga  cacaagtta  540
aagcagtgt  cggtgtcca  acgagaacc  tacagcgag  gatagagag  g  591



<210> 5614
<211> 1101
<212> DNA
<213> Homo sapiens
<308> BC005192
<400> 5614

cttgagttc  ttctccttc  ctctctctc  ttttttttt  aataactct  ctgggaagt  60
ggtttataa  cctttgcca  gtgtaactg  tgtgaaata  ccaccacta  agttttttt  120
agttccata  tttctccat  ttgccttct  atgtatttt  aagattatt  tgtgcactt  180
aaatttact  aacttacca  aaatgcagt  tgacttttc  cacacactg  attgtgagg  240
tcttaactt  ttaaaagta  aatggcatc  tgtgaatcc  ataagcagt  tttatgtct  300
ttaacattc  cacctactt  ttaaaaaca  atattatta  tatttttat  attgtttgt  360
ctttataaa  tttcttaaa  attaagaaa  tttaagacc  cattgagtt  ctgtaatgc  420
attcaactt  gagttatct  ttaaatatg  cttgtatag  tcatattca  ggctgaaac  480
tgaccacac  attgctgat  gtatggttt  cacctggac  ccgtgtaga  tgcttgatt  540
cttgtactc  tcttatgct  atatgctct  ggctggaga  atgaaatcc  caagccatc  600
ggatttgct  tttaagtgg  ttgacaact  ggccaccaa  gaacttgaa  ttcaccttt  660
aggatttga  ctgttctgg  acacattgc  gcactttgg  aagtcaaaa  caagtgcca  720
tggcgccct  tccatagag  atttgccca  ctttgcttt  aaagatgtc  tgtttttta  780
atacacata  tcaataggt  caatctgct  tcaaggcct  ggtcctggt  ggattcctt  840
accaattac  ttaattaaa  atggctgca  ctgtaagaa  ccttgtctg  tatatttgc  900
actatgctc  catttacaa  tgtaccttc  aatgctcag  tgccaggtt  caatgcaaa  960
gtggcgtgg  ctccctttg  gtgggtggg  tttgtgggt  gtggtgaag  accgatatc  1020
gaaaaatgc  ttcaagtgt  ctaatttat  aataaacat  aggtgtttg  taaaaaaaa  1080
aaaaaaaaa  aaaaaaaaa  a  1101



<210> 5615
<211> 124
<212> PRT
<213> Homo sapiens
<308> AAF64274
<400> 5615

Met Gln Phe Asn Phe Glu Leu Ser Phe Lys Tyr Val Leu Tyr Ser Ser 
  1               5                  10                  15
Tyr Ser Trp Leu Lys Leu Asp His Thr Ile Ala Asp Cys Met Val Phe 
             20                  25                  30
Thr Trp Thr Pro Cys Arg Met Leu Asp Tyr Leu Tyr Ser Ser Tyr Ala 
         35                  40                  45
Asn Met Leu Trp Ala Gly Glu Met Lys Ser Ser Ser His Gln Asp Leu 
     50                  55                  60
Leu Phe Lys Trp Leu Asp Asn Trp Ala Thr Lys Glu Leu Glu Leu His 
 65                  70                  75                  80
Leu Leu Gly Phe Glu Leu Phe Trp Asn Thr Leu Leu His Phe Gly Lys 
                 85                  90                  95
Ser Lys Ser Ser Ala Ser Gly Ala Leu Ser Ile Glu Asn Leu Pro Ser 
             100                105                110
Phe Ala Leu Lys Asp Val Leu Phe Phe Ile Tyr Thr 
         115                120



<210> 5616
<211> 617
<212> DNA
<213> Rattus norvegicus
<308> AA891848
<400> 5616

gatataaat  agtttattg  tggatttcc  cattaacat  atagaaata  tttaaaatc  60
ctaaaagtc  caaattgag  gcccaacag  taaccatac  ttataaaaa  gaaagtata  120
aagcggctt  taaaatttt  tgaaaagta  atcagctga  agcaaagaa  taggaacca  180
tcagtaaat  gcacaaata  atcactgaa  ttctcagtc  tcacctaca  gtcagtgtc  240
gagctatga  gtagacctg  tttataagt  acacactga  tagtgttcc  aactgtcct  300
cctcacttc  ataagagaa  ccaaatctt  tactgctat  gggacaaag  actatccat  360
aactggaga  gaaggctca  cttcctctc  cagtacctg  acaacagaa  agtgtgcac  420
gaaacggct  tggcacttg  accctcaga  actgtctta  acgttgttg  ttgaatatt  480
tagttttac  tggtgctct  acctacatt  ttgtctcca  gctctgtgg  tatcacaca  540
acacacaca  acacacaca  acacagata  aaacagcca  ggcactcat  cacataaaa  600
taacaataa  aattttt  617



<210> 5617
<211> 526
<212> PRT
<213> Rattus norvegicus
<308> P04762
<400> 5617

Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Lys Gln Trp Lys Glu 
  1               5                  10                  15
Gln Arg Ala Pro Gln Lys Pro Asp Val Leu Thr Thr Gly Gly Gly Asn 
             20                  25                  30
Pro Ile Gly Asp Lys Leu Asn Ile Met Thr Ala Gly Pro Arg Gly Pro 
         35                  40                  45
Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe Asp 
     50                  55                  60
Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly Ala 
 65                  70                  75                  80
Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Arg Tyr Ser Lys Ala 
                 85                  90                  95
Lys Val Phe Glu His Ile Gly Lys Arg Thr Pro Ile Ala Val Arg Phe 
             100                105                110
Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp Pro 
         115                120                125
Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp Leu 
     130                135                140
Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Ala Met Leu Phe 
 145                150                155                160
Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu Lys 
                 165                170                175
Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Cys Pro Glu Ser Leu 
             180                185                190
His Gln Val Thr Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly His 
         195                200                205
Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn Ala 
     210                215                220
Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln Gly 
 225                230                235                240
Ile Lys Asn Leu Pro Val Glu Glu Ala Gly Arg Leu Ala Gln Glu Asp 
                 245                250                255
Pro Asp Tyr Gly Leu Arg Asp Leu Phe Asn Ala Ile Ala Ser Gly Asn 
             260                265                270
Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Lys Glu Ala 
         275                280                285
Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro His 
     290                295                300
Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg Asn 
 305                310                315                320
Pro Ala Asn Tyr Phe Ala Glu Val Glu Gln Met Ala Phe Asp Pro Ser 
                 325                330                335
Asn Met Pro Pro Gly Ile Glu Pro Ser Pro Asp Lys Met Leu Gln Gly 
             340                345                350
Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro Asn 
         355                360                365
Tyr Leu Gln Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala Asn 
     370                375                380
Tyr Gln Arg Asp Gly Pro Met Cys Met His Asp Asn Gln Gly Gly Ala 
 385                390                395                400
Pro Asn Tyr Tyr Pro Asn Ser Phe Ser Ala Pro Glu Gln Gln Gly Ser 
                 405                410                415
Ala Leu Glu His His Ser Gln Cys Ser Ala Asp Val Lys Arg Phe Asn 
             420                425                430
Ser Ala Asn Glu Asp Asn Val Thr Gln Val Arg Thr Phe Tyr Thr Lys 
         435                440                445
Val Leu Asn Glu Glu Glu Arg Lys Arg Leu Cys Glu Asn Ile Ala Asn 
     450                455                460
His Leu Lys Asp Ala Gln Leu Phe Ile Gln Arg Lys Ala Val Lys Asn 
 465                470                475                480
Phe Thr Asp Val His Pro Asp Tyr Gly Ala Arg Val Gln Ala Leu Leu 
                 485                490                495
Asp Gln Tyr Asn Ser Gln Lys Pro Lys Asn Ala Ile His Thr Tyr Val 
             500                505                510
Gln Ala Gly Ser His Ile Ala Ala Lys Gly Lys Ala Asn Leu 
         515                520                525



<210> 5618
<211> 2264
<212> DNA
<213> Homo sapiens
<308> X04076
<400> 5618

tttgcctgc  gagggtgga  acccacgag  cgaggcctc  tgcagtgtt  tgcacagca  60
accgcacgc  atggctgac  gccgggatc  cgccagcga  cagatgcag  actggaagg  120
gcagcgggc  gcgcagaaa  ctgatgtcc  gaccactgg  gctggtaac  cagtaggag  180
caaacttaa  gttattaca  tagggcccc  tgggcccct  cttgttcag  atgtggttt  240
cactgatga  atggctcat  ttgaccgag  gagaattcc  gagagagtt  tgcatgcta  300
aggagcagg  gcctttggc  actttgagg  cacacatga  attaccaaa  actccaagg  360
aaaggtatt  gagcatatt  gaaagaaga  tcccatcgc  gttcggttc  ccactgttg  420
tggagaatc  ggttcagct  acacagttc  ggaccctcg  gggtttgca  tgaaatttt  480
cacagaaga  ggtaactgg  atctcgttg  aaataacac  cccattttc  tcatcaggg  540
tcccatatt  tttccatct  ttatccaca  ccaaaagag  aatcctcag  cacatctga  600
ggatccgga  atggtctgg  acttctgga  cctacgtcc  gagtctctg  atcaggttt  660
tttcttgtt  agtgatcgg  ggattccag  tggacatcg  cacatgaat  gatatggat  720
acatacttt  aagctggtt  atgcaaatg  ggaggcagt  tattgcaaa  tccattata  780
gactgacca  ggcatcaaa  acctttctg  tgaagatgc  gcgagactt  cccaggaag  840
tcctgacta  ggcatccgg  atcttttta  cgccattgc  acaggaaag  acccctcct  900
gacttttta  atccaggtc  tgacattta  tcaggcaga  acttttcca  ttaatccat  960
cgatctcac  aaggtttgg  ctcacaagg  ctaccctct  atcccagtt  gtaaactgg  1020
cttaaaccg  aatccagtt  attactttg  tgaggttga  cagatagcc  tcgacccaa  1080
caacatgcc  cctggcatt  aggccagtc  tgacaaaat  cttcagggc  gcctttttg  1140
ctatcctga  actcaccgc  atcgcctgg  acccaatta  cttcatata  ctgtgaact  1200
tccctaccg  gctcgagtg  ccaactacc  gcgtgatgg  ccgatgtgc  tgcaggaca  1260
tcagggtgg  gctccaaat  actacccca  cagctttgg  gctccggaa  aacagcctt  1320
tgccctgga  cacagcatc  aatattctg  agaagtgcg  agattcaac  ctgccaatg  1380
tgataacgt  actcaggtg  gggcattct  tgtgaacgt  ctgaatgag  aacagagga  1440
acgtctgtg  gagaacatt  ccggccacc  gaaggatgc  caaattttc  tccagaaga  1500
agcggtcaa  aacttcact  aggtccacc  tgactacgg  agccacatc  aggctcttc  1560
ggacaagta  aatgctgag  agcctaaga  tgcgattca  acctttgtg  agtccggat  1620
tcacttggc  gcaagggag  aggcaaatc  gtgaggccg  ggccctgca  ctgtgcagc  1680
aacgttagc  ttcatccgt  taacccgct  atcactgga  gaagattct  ctgtgctag  1740
tgtgcaaat  caagctagt  gcttcaaaa  agagaatcc  actttctat  gcagattgt  1800
taacaattt  aatgctatt  ccccagggg  aaatgaagg  taggattta  cagtcattt  1860
aaaaaaaaa  ttgttttga  ggatgattg  attattcat  taaaatgat  agaaggcaa  1920
tttctagct  agaaatatg  ttttatttg  caaaatttg  tgaaattat  tatgtttac  1980
tatcacctc  tggcctatt  tattaaaat  tggctataa  tatataaaa  gaaaagata  2040
agatgatct  ctcagaaat  tttattttt  taaggttct  ataggaaaa  tacatttaa  2100
acagcagtg  catcagaag  taacttgag  accgtcatg  cttaatgtt  attcctgat  2160
ataattgat  aaattcatt  ttttcactg  agttacatt  atgttaatt  agcactgat  2220
tcacaacag  tcaatttgt  attgcttac  tttttacaa  aaat  2264



<210> 5619
<211> 526
<212> PRT
<213> Homo sapiens
<308> P04040
<400> 5619

Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys Glu 
  1               5                  10                  15
Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly Asn 
             20                  25                  30
Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly Pro 
         35                  40                  45
Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe Asp 
     50                  55                  60
Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly Ala 
 65                  70                  75                  80
Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys Ala 
                 85                  90                  95
Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg Phe 
             100                105                110
Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp Pro 
         115                120                125
Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp Leu 
     130                135                140
Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu Phe 
 145                150                155                160
Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu Lys 
                 165                170                175
Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser Leu 
             180                185                190
His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly His 
         195                200                205
Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn Ala 
     210                215                220
Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln Gly 
 225                230                235                240
Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu Asp 
                 245                250                255
Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly Lys 
             260                265                270
Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln Ala 
         275                280                285
Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro His 
     290                295                300
Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg Asn 
 305                310                315                320
Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro Ser 
                 325                330                335
Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln Gly 
             340                345                350
Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro Asn 
         355                360                365
Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala Asn 
     370                375                380
Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly Ala 
 385                390                395                400
Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro Ser 
                 405                410                415
Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe Asn 
             420                425                430
Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val Asn 
         435                440                445
Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala Gly 
     450                455                460
His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys Asn 
 465                470                475                480
Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu Leu 
                 485                490                495
Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe Val 
             500                505                510
Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu 
         515                520                525



<210> 5620
<211> 501
<212> DNA
<213> Rattus norvegicus
<308> AA891857
<400> 5620

actcacagc  catgtttat  gaagggata  atacagatg  tgatgtaga  ctctctcag  60
agtcacaca  tatcctggg  ctccacctt  ctgggaggc  gagacagga  gatcgtatt  120
aagaccaat  tgcccacag  aaaaccacc  tctctcctg  ggtcaggga  agctagcta  180
ctgcctgat  gcgagtctc  gggctgttc  gcaggaaca  ctggcacgg  agaggcagc  240
tcgtagtcc  ccatgcggc  ctggaccag  gcgggcatg  ggtgcacgt  agcggccat  300
aggcggtgg  tagaatgga  gagcttccc  gcacagctg  gcaggcagg  ctcctcctc  360
gcgtccaga  ctcggtggt  caggctggg  acacagcgc  ggaagcaca  ttctgtcat  420
cgattgtag  ccaacagaa  gtctcgcaa  tttctcagt  gctgctgct  gtgctccat  480
acgcccagg  cgcatggcg  c  501



<210> 5621
<211> 100
<212> PRT
<213> Rattus norvegicus
<308> Q9R1B1
<400> 5621

Met Glu His Gln Gln Gln Gln Leu Arg Asn Leu Arg Asp Phe Leu Leu 
  1               5                  10                  15
Val Tyr Asn Arg Met Thr Glu Leu Cys Phe Gln Arg Cys Val Pro Ser 
             20                  25                  30
Leu His His Arg Ala Leu Asp Ala Glu Glu Glu Ala Cys Leu His Ser 
         35                  40                  45
Cys Ala Gly Lys Leu Ile His Ser Asn His Arg Leu Met Ala Ala Tyr 
     50                  55                  60
Val His Leu Met Pro Ala Leu Val Gln Arg Arg Met Ala Asp Tyr Glu 
 65                  70                  75                  80
Ala Ala Ser Ala Val Pro Gly Val Pro Ala Glu Gln Pro Arg Asp Ser 
                 85                  90                  95
Pro Ser Gly Ser 
             100



<210> 5622
<211> 421
<212> DNA
<213> Homo sapiens
<308> AI005112
<400> 5622

tgtttaaag  ctttattgc  aatttcaca  aggcaggaa  tactaagag  gtaaattgg  60
gaaatggtc  acattcctg  attcttaga  gcttgtctt  gttctgttg  cactgacct  120
ctaggaagc  gtggctaaa  cctaagggg  tagagtttt  ttcctgctt  tgttgtttg  180
ttttacctt  ttcccctag  ttcacagca  ttctttttg  cagcttctc  ccaggggcc  240
gggacggct  gctgcctga  ggcgagtct  tggtctgtt  tgcaggaat  cctggcgcg  300
ccgaggcag  ctcgtagtc  gcgatgcgg  gctggacca  ggcgggcat  aggtgcacg  360
aagcggcca  gaggcggtg  ttagaatgg  tgagtttcc  agcacagct  tgcaggcag  420
c  421



<210> 5623
<211> 103
<212> PRT
<213> Homo sapiens
<308> NP_036324
<400> 5623

Met Glu Arg Gln Gln Gln Gln Gln Gln Gln Leu Arg Asn Leu Arg Asp 
  1               5                  10                  15
Phe Leu Leu Val Tyr Asn Arg Met Thr Glu Leu Cys Phe Gln Arg Cys 
             20                  25                  30
Val Pro Ser Leu His His Arg Ala Leu Asp Ala Glu Glu Glu Ala Cys 
         35                  40                  45
Leu His Ser Cys Ala Gly Lys Leu Ile His Ser Asn His Arg Leu Met 
     50                  55                  60
Ala Ala Tyr Val Gln Leu Met Pro Ala Leu Val Gln Arg Arg Ile Ala 
 65                  70                  75                  80
Asp Tyr Glu Ala Ala Ser Ala Val Pro Gly Val Ala Ala Glu Gln Pro 
                 85                  90                  95
Gly Val Ser Pro Ser Gly Ser 
             100



<210> 5624
<211> 570
<212> DNA
<213> Rattus norvegicus
<308> AA891859
<400> 5624

aaggataat  ctgtttatt  aaaatatac  caggaagtc  gggtattga  gcaatttta  60
atacacact  ggtagtctg  agttccatt  ttccagcag  ttatataaa  gtttcagat  120
aaaagagaa  gaaaacact  tacagagac  agcagttgc  tatcagttt  gtcatgagt  180
tgcttgtag  aaaaataaa  ctccctctt  cattgctga  gaatgtcct  aatagagaa  240
aagttctgt  agcactaag  aagttcttc  tgcattaat  actattcgt  tgaacttct  300
agcatatgc  aactttttg  ccctgttaa  tgctgtggg  tgtgccagg  ctattacct  360
tctaggcaa  tgagacttt  cagtgacgt  tcactaggt  tctctcgcc  tactgtgga  420
gccactact  cagcatcaa  cctaacacc  atgtaacac  tttcaaaag  atcatataa  480
acaaaacag  tcaagacaa  atgctcatt  caatgggga  aacaaaacg  gtcagaaaa  540
tgaaagcgt  aaagaaatg  aagccacttc  570



<210> 5625
<211> 490
<212> DNA
<213> Homo sapiens
<308> AA781413
<400> 5625

ttaggataa  gctgtttat  aaaaatata  tcagggaga  ggaagtcag  gcatttatg  60
aattttaca  acacatctg  agtttgagg  tccattatt  caacagttc  tataaatca  120
tgtttcaga  aaaaggaaa  aaatgcttt  cacaggaga  cagcaattg  ttataggtt  180
ggaaatatg  gtcggcttg  agtaaaaat  aaaccacct  ttccattat  aaagaatgt  240
tccttcatg  agaacaagt  tttagcatt  agaactttt  cttgcataa  aattgttaa  300
ttgaagttc  tggaaaaca  ccaatcctg  tttctatat  tataaatgc  attttgtct  360
gattttttt  tttgaggta  caaaggaag  atcttcagt  atttgtcac  aggttatcc  420
ttaccgtgt  tgtcaacta  tgcaatgtc  aacctaaga  ttatacaaa  gcatttctc  480
gagaatcata  490



<210> 5626
<211> 608
<212> DNA
<213> Rattus norvegicus
<308> AA891864
<400> 5626

gaaaccaaa  aggcccaag  tccttttcg  cttgagtca  ctgtctgaa  gcttgtccc  60
ctcatactt  ctgtgcaac  aaaaccaag  catttcatt  cttcttggc  attaacaaa  120
gtggaagaa  gttcaaata  ggtgtgttc  tgatacctc  gagtcggaa  gggcttcgt  180
ttgggcaga  ggctcataa  cgcctgtat  ctccgctaa  tcaacctct  actcgtcat  240
gctttctgc  ctgtaatca  cttcttcaa  gaaccgagg  tcatcttca  ccaaaacgt  300
agtagtggg  ctagttact  tacagcttg  ttcaattaa  tcattttca  agtcaagca  360
gttggaggg  agattgtac  ccaatggag  agtcagtct  ttcaaacgc  ataaaccaa  420
acaaaattt  gctcccatt  cttccagtt  tcgagtccc  atctgtaaa  ccttgtatc  480
accctgatc  cagccacat  aagtactct  catggtata  ctcctttga  ctccaattt  540
ccgccacac  acaacccga  ctgtggact  tttggattt  tccaccaca  agctacagc  600
gctcatgc  608



<210> 5627
<211> 1160
<212> PRT
<213> Rattus norvegicus
<308> AAG37102
<400> 5627

Met Thr Thr Lys Gly Ser Thr Gly Met Glu Val Leu Leu Ser Thr Leu 
  1               5                  10                  15
Glu Asn Thr Lys Asp Leu Gln Thr Val Leu Asn Ile Leu Ser Ile Leu 
             20                  25                  30
Ile Glu Leu Val Ser Ser Gly Gly Gly Arg Arg Ala Ser Phe Leu Val 
         35                  40                  45
Ala Lys Gly Gly Ser Gln Ile Leu Leu Gln Leu Leu Met Asn Ala Ser 
     50                  55                  60
Lys Asp Ser Pro Pro His Glu Glu Val Met Val Gln Thr His Ser Ile 
 65                  70                  75                  80
Leu Ala Lys Ile Gly Pro Lys Asp Lys Lys Phe Gly Val Lys Ala Arg 
                 85                  90                  95
Val Asn Gly Ala Leu Thr Val Thr Leu Asn Leu Val Lys Gln His Phe 
             100                105                110
Gln Asn Tyr Arg Leu Val Leu Pro Cys Leu Gln Leu Leu Arg Val Tyr 
         115                120                125
Ser Thr Asn Ser Val Asn Ser Val Ser Leu Gly Lys Asn Gly Val Val 
     130                135                140
Glu Leu Met Phe Lys Ile Ile Gly Pro Phe Ser Lys Lys Asn Ser Gly 
 145                150                155                160
Leu Met Lys Val Ala Leu Asp Thr Leu Ala Ala Leu Leu Lys Ser Lys 
                 165                170                175
Thr Asn Val Arg Arg Ala Val Asp Arg Gly Tyr Val Gln Val Leu Leu 
             180                185                190
Thr Ile Tyr Val Asp Trp His Arg His Asp Asn Arg His Arg Asn Met 
         195                200                205
Leu Ile Arg Lys Gly Ile Leu Arg Ser Leu Lys Ser Val Thr Asn Ile 
     210                215                220
Lys Leu Gly Arg Lys Ala Phe Ile Asp Ala Asn Gly Met Lys Ile Leu 
 225                230                235                240
Tyr Asn Thr Ser Gln Glu Cys Leu Ala Val Arg Thr Leu Asp Pro Leu 
                 245                250                255
Val Asn Thr Ser Ser Leu Ile Met Arg Lys Cys Phe Pro Lys Asn Arg 
             260                265                270
Leu Pro Leu Pro Thr Ile Lys Ser Ser Phe His Phe Gln Leu Pro Ile 
         275                280                285
Ile Pro Val Thr Gly Pro Val Ala Gln Leu Tyr Ser Leu Pro Pro Glu 
     290                295                300
Val Asp Asp Val Val Asp Glu Ser Asp Asp Asn Asp Asp Ile Asp Leu 
 305                310                315                320
Glu Val Glu Asn Glu Leu Glu Asn Glu Asp Asp Leu Asp Gln Ser Phe 
                 325                330                335
Lys Asn Asp Asp Ile Glu Thr Asp Ile Asn Lys Leu Arg Pro Gln Gln 
             340                345                350
Val Pro Gly Arg Thr Ile Glu Glu Leu Lys Met Tyr Glu His Leu Phe 
         355                360                365
Pro Glu Leu Val Asp Asp Phe Gln Asp Tyr Glu Leu Ile Ser Lys Glu 
     370                375                380
Pro Lys Pro Phe Val Phe Glu Gly Lys Ala Arg Gly Pro Ile Val Val 
 385                390                395                400
Pro Thr Ala Gly Glu Glu Val Pro Gly Asn Ser Gly Ser Val Lys Lys 
                 405                410                415
Gly Val Val Met Lys Glu Arg Ala Ser Pro Lys Gly Glu Glu Ala Lys 
             420                425                430
Glu Asp Pro Lys Gly His Asp Arg Thr Leu Pro Gln Gln Leu Gly Gly 
         435                440                445
Gln Ser Arg Val Ala Pro Ser Ala His Ser Phe Asn Asn Asp Leu Val 
     450                455                460
Lys Ala Leu Asp Arg Ile Thr Leu Gln Asn Val Pro Ser Gln Val Ala 
 465                470                475                480
Ser Gly Leu Glu Arg Arg Asn Glu Glu Gly Phe Gly Leu Pro Leu Thr 
                 485                490                495
Val Leu Ser Cys Thr Lys Ala Cys Pro His Val Ala Lys Cys Gly Ser 
             500                505                510
Thr Leu Phe Glu Gly Arg Thr Val His Leu Gly Lys Leu Cys Cys Thr 
         515                520                525
Gly Val Glu Thr Glu Asp Asp Glu Asp Thr Glu Ser His Ser Ser Thr 
     530                535                540
Glu Gln Ala Pro Ser Val Glu Ala Ser Asp Gly Pro Thr Leu His Asp 
 545                550                555                560
Pro Asp Leu Tyr Ile Glu Ile Val Lys Asn Thr Lys Ser Val Pro Glu 
                 565                570                575
Tyr Ser Glu Val Ala Tyr Pro Asp Tyr Ser Gly His Ile Pro Pro Pro 
             580                585                590
Phe Lys Glu Pro Ile Leu Glu Arg Pro Tyr Gly Val Gln Arg Thr Lys 
         595                600                605
Ile Ala Gln Asp Ile Glu Arg Leu Ile His Gln Asn Asp Ile Ile Asp 
     610                615                620
Arg Val Val Tyr Asp Leu Asp Asn Pro Thr Tyr Thr Thr Pro Glu Glu 
 625                630                635                640
Gly Asp Thr Leu Lys Phe Asn Ser Lys Phe Glu Ser Gly Asn Leu Arg 
                 645                650                655
Lys Val Ile Gln Ile Arg Lys Ser Glu Tyr Asp Leu Ile Leu Asn Ser 
             660                665                670
Asp Ile Asn Ser Asn His Tyr His Gln Trp Phe Tyr Phe Glu Val Ser 
         675                680                685
Gly Met Arg Pro Gly Val Ala Tyr Arg Phe Asn Ile Ile Asn Cys Glu 
     690                695                700
Lys Ser Asn Ser Gln Phe Asn Tyr Gly Met Gln Pro Leu Met Tyr Ser 
 705                710                715                720
Val Gln Glu Ala Leu Asn Ala Arg Pro Trp Trp Ile Arg Met Gly Thr 
                 725                730                735
Asp Ile Cys Tyr Tyr Lys Asn His Phe Ser Arg Ser Ser Val Ala Ala 
             740                745                750
Gly Gly Gln Lys Gly Lys Ser Tyr Tyr Thr Ile Thr Phe Thr Val Asn 
         755                760                765
Phe Pro His Lys Asp Asp Val Cys Tyr Phe Ala Tyr His Tyr Pro Tyr 
     770                775                780
Thr Tyr Ser Thr Leu Gln Met His Leu Gln Lys Leu Glu Ser Ala His 
 785                790                795                800
Asn Pro Gln Gln Ile Tyr Phe Arg Lys Asp Val Leu Cys Glu Thr Leu 
                 805                810                815
Ser Gly Asn Ile Cys Pro Leu Val Thr Ile Thr Ala Met Pro Glu Ser 
             820                825                830
Asn Tyr Tyr Glu His Ile Cys Gln Phe Arg Thr Arg Pro Tyr Ile Phe 
         835                840                845
Leu Ser Ala Arg Val His Pro Gly Glu Thr Asn Ala Ser Trp Val Met 
     850                855                860
Lys Gly Thr Leu Glu Tyr Leu Met Ser Asn Ser Pro Thr Ala Gln Ser 
 865                870                875                880
Leu Arg Glu Ser Tyr Ile Phe Lys Ile Val Pro Met Leu Asn Pro Asp 
                 885                890                895
Gly Val Ile Asn Gly Asn His Arg Cys Ser Leu Ser Gly Glu Gly Leu 
             900                905                910
Asn Arg Gln Trp Gln Ser Pro Asn Pro Glu Leu His Pro Thr Ile Tyr 
         915                920                925
His Ala Lys Gly Leu Leu Gln Tyr Leu Ala Ala Val Lys Arg Leu Pro 
     930                935                940
Leu Val Tyr Cys Asp Tyr His Gly His Ser Arg Lys Lys Asn Val Phe 
 945                950                955                960
Met Tyr Gly Cys Ser Ile Lys Glu Thr Val Trp His Thr His Asp Asn 
                 965                970                975
Ser Ala Ser Cys Asp Ile Val Glu Gly Met Gly Tyr Arg Thr Leu Pro 
             980                985                990
Lys Ile Leu Ser His Ile Ala Pro Ala Phe Cys Met Ser Ser Cys Ser 
         995                1000                1005
Phe Val Val Glu Lys Ser Lys Glu Ser Thr Ala Arg Val Val Val Trp 
     1010                1015                1020
Arg Glu Ile Gly Val Gln Arg Ser Tyr Thr Met Glu Ser Thr Leu Cys 
 1025                1030                1035                1040
Gly Cys Asp Gln Gly Arg Tyr Lys Gly Leu Gln Ile Gly Thr Arg Glu 
                 1045                1050                1055
Leu Glu Glu Met Gly Ala Gln Phe Cys Val Gly Leu Leu Arg Leu Lys 
             1060                1065                1070
Arg Leu Thr Ser Ser Leu Glu Tyr Asn Leu Pro Ser Asn Leu Leu Asp 
         1075                1080                1085
Phe Glu Asn Asp Leu Ile Glu Ser Ser Cys Lys Val Thr Ser Pro Thr 
     1090                1095                1100
Thr Tyr Val Leu Asp Glu Asp Glu Pro Arg Phe Leu Glu Glu Val Asp 
 1105                1110                1115                1120
Tyr Ser Ala Glu Ser Asn Asp Glu Leu Asp Val Glu Leu Ala Glu Asn 
                 1125                1130                1135
Thr Gly Asp Tyr Glu Pro Ser Ala Gln Glu Glu Ala Leu Ser Asp Ser 
             1140                1145                1150
Glu Val Ser Arg Thr His Leu Ile 
         1155                1160



<210> 5628
<211> 4218
<212> DNA
<213> Homo sapiens
<308> XM_043746
<400> 5628

acgttgccc  ggatgcgga  aggttccgc  gcctccagc  ccccatcct  agccgatta  60
ctgcaatta  gaaatgaag  aactcaaga  gagcaagtt  aaagtgata  cagaaaaaa  120
ccttaccaa  aattctagg  tcgtaggac  cctggctca  ctggagaag  tcaatgctg  180
gccttcaga  tcagacact  cccgatatg  tacatcaaa  attcttcat  tggctcaga  240
tcaagaaaa  acaaggaga  aaatgacag  caaaggttc  acaggaatg  aaattctgc  300
gtcaacatt  gagaacaca  aagatcttc  aactacact  aatatctta  gcattcttg  360
tgagctggt  tcagctggt  gaggtcgaa  agtgagttt  ttagtcacc  aaggtggtt  420
acaaatatt  ttgcagtta  ttatgaatg  cagcaaaga  tctccccca  atgaggact  480
aatggtaca  attcattct  ttcttgcaa  gattggacc  aaagataaa  aatttggag  540
aaaggctag  attaatggg  ctctgaata  aaccctgaa  ttggtcaag  agaatttgc  600
gaatcatcg  ttggttcta  cttgccttc  gcttttacg  gtatattct  ccaactctg  660
gaattcagt  tccttaggg  aaaatggag  tgtggaact  atgtttaaa  tcattggac  720
atttagtaa  aagaattcc  gtcttataa  ggttgcttt  gacactctt  ctgcattgc  780
aaaatcaaa  acaaatgcc  ggagagctg  agacagagg  tatgtccaa  tgcttttaa  840
aatttatgt  gattggcac  gccatgata  ccggcatag  aacatgctc  ttcggaaag  900
aattttaca  agtttaaaa  gtgttacaa  catcaagtt  ggaagaaaa  catttattg  960
tgccaatgg  atgaaaatt  tgtataata  ttcgcaatt  cctgttatt  ctgtgactg  1020
tcctgtggc  cagctctac  gcttacctc  tgaagtgga  gacgtagta  atgaaagtg  1080
tgacaacga  gatattgat  tagaagctg  aaacgaaac  gagaatgaa  atgacctag  1140
tcaaaattt  aagaatgat  atattgaaa  agatattaa  aaactaaaa  cccagcaag  1200
accgggacg  acaatagaa  atctaaaaa  gtatgaaca  cttttccct  agcttgttg  1260
tgattttca  gactatgat  taatctcca  agaaccaaa  ccttttgta  ttgagggaa  1320
agtacgtgg  cctattgtt  ttcctacgg  aggcgagga  acatctggg  attctggca  1380
tttaagaaa  gttgtaatg  aggagaaca  atcttctaa  ggagatgaa  gtgaaaaga  1440
gtctacctt  atggatcta  caaaagaag  tattaaaga  aatgataga  cattacaac  1500
gcagccagg  gatcaaaat  gaactattt  atcagtcca  ggtttaaac  atgatattg  1560
aaaggcctt  gaccgaatt  cattgcaga  tattccttc  caaacagcc  caggtttta  1620
tgcagaaat  aagaaggac  gcagtcttc  tcttactgt  cttacctgt  ctaaagcat  1680
tccacacat  gctacttgt  gaaatgttc  gtttgaggg  agaacagtt  agctaggga  1740
gctttgctg  actggagtt  aaactgaag  tgatgaaga  actgagtca  attcatcgg  1800
agaacaagc  tcggttgaa  tacctgatg  accaacact  catgaccca  acctctata  1860
tgagattgt  aaaaatacg  agtctgtcc  agaatattc  gaggtggct  atcccgatt  1920
ttttggtca  attccgcct  cattcaaag  gcctatttt  gaaaggcct  atggtgtac  1980
aaggacaaa  attgctcaa  atattgaaa  gctaataca  cagagtgat  tcatagatc  2040
tgtggtata  gacttggat  acccaaatt  caccattcc  gaagaggga  atattttga  2100
atttaactc  aaatttgag  ctgggaatc  gcgcaaagt  attcaaatt  gaaaaaatg  2160
atatgatct  attctgaac  cagacataa  cagcaatca  tatcatcag  ggttttact  2220
tgaagtcag  ggaatgcga  caggtgttg  ttacaggtt  aacatcatt  actgtgaaa  2280
gtccaacag  cagtttaat  atggtatgc  accactcat  tattcggtt  aggaagcat  2340
aaatgccag  ccatggtgg  ttcgtatgg  gactgacat  tgttactat  aaaatcatt  2400
ctcaagaag  tcagttgct  caggtgggc  aaagggaaa  tcctactat  caattacat  2460
tactgtcaa  tttccacat  aagatgatg  ttgctactt  gcttatcac  atccatata  2520
gtattcaac  ttacagatg  atcttcaaa  attggaatc  gcacacaat  ctcagcaaa  2580
ctattttcg  aaagatgtg  tatgtgaaa  cctgtctgg  aacagctgc  ccttggtga  2640
tataacagc  atgccagag  ctaattatt  tgaacatat  tgccatttc  gaaatcgcc  2700
ttacgtttt  ttgtctgct  gggtacatc  tggagaaac  aatgcaagt  gggttatga  2760
aggaacgtt  gaatatctc  tgagcaata  ccccactgc  cagagctta  gagaatctt  2820
tatttttaa  attgtccct  tgttaaatc  agatggtgt  atcaatgga  atcatcgct  2880
ttctttaag  ggagaggat  tgaataggc  gtggcaaag  ccaagtccg  atttacatc  2940
tacaattta  catgctaag  ggctgttgc  atacttggc  gcagtgaag  gtttaccct  3000
ggtttattg  gattatcat  gccattccc  aaagaagaa  gtatttatg  atggttgca  3060
catcaaaga  acagtgtgg  ataccaatg  taatgcaac  tcatgtgat  ttgtggagg  3120
tacgggata  aggacattg  ctaagatac  gagccatat  gccccagca  tttgcatga  3180
cagctgtag  ttcgtagtg  aaaaatcta  agaatccac  gcacgtgtt  tagtttgga  3240
ggaaatagg  gtacaaaga  gttatacca  ggagagtac  ttatgtggc  gtgatcagg  3300
aaaatacaa  ggtttacag  ttggtaccc  agaactgga  gagatggga  caaaatttt  3360
tgttggtct  ttacgtttg  aaagactga  ctctccatt  gagtataat  tgccttcca  3420
cctgcttga  tttgaaaat  atttaattg  atcaagctg  aaagtaact  gccctacca  3480
ttatgtctt  gatgaagat  aacctcgat  ccttgaaga  gttgattac  gtgcagaaa  3540
taatgatga  ttagatatt  agttggctg  aaatgtagg  gattatgaa  cttctgctc  3600
agaagaagt  ctttctgac  ctgaattat  aagaacata  ctaccttga  cccgctgcc  3660
tctcttgtt  actgcaaag  ataaatgaa  tatcttggt  tttatttcc  aggaagctt  3720
agagaaatg  gtttataca  agctgactc  aaaagacaa  aagtaactt  ggccagttt  3780
gtttcaaga  aataaatgt  ttattaatt  atgataaaa  tggcgcttg  tttattttc  3840
atattcaat  cactttatg  agcattgaa  gatcaaata  tggatttac  tttaaaaaa  3900
aaacctgag  atcattgca  gaattttta  ctccctatg  ttatatcct  catcaagtg  3960
ataattttg  agtgtgttc  gaatataaa  ttgaaattt  agagttgtt  aaaatcctg  4020
cttgttgaa  actaatata  atgtacatg  atttctata  atgtgtttg  ttagaagtg  4080
gtagatatt  cagataaga  tgttcttca  aatcatgtt  actattggg  tgtgactga  4140
gtagtccag  gtttgcctt  aaaccatta  attctacat  taccaaatt  aacaaataa  4200
aactgtatt  aatgttgc  4218



<210> 5629
<211> 1186
<212> PRT
<213> Homo sapiens
<308> XP_043746
<400> 5629

Met Ser Lys Leu Lys Val Ile Pro Glu Lys Ser Leu Thr Asn Asn Ser 
  1               5                  10                  15
Arg Ile Val Gly Leu Leu Ala Gln Leu Glu Lys Ile Asn Ala Glu Pro 
             20                  25                  30
Ser Glu Ser Asp Thr Ala Arg Tyr Val Thr Ser Lys Ile Leu His Leu 
         35                  40                  45
Ala Gln Ser Gln Glu Lys Thr Arg Arg Glu Met Thr Ala Lys Gly Ser 
     50                  55                  60
Thr Gly Met Glu Ile Leu Leu Ser Thr Leu Glu Asn Thr Lys Asp Leu 
 65                  70                  75                  80
Gln Thr Thr Leu Asn Ile Leu Ser Ile Leu Val Glu Leu Val Ser Ala 
                 85                  90                  95
Gly Gly Gly Arg Arg Val Ser Phe Leu Val Thr Lys Gly Gly Ser Gln 
             100                105                110
Ile Leu Leu Gln Leu Leu Met Asn Ala Ser Lys Glu Ser Pro Pro His 
         115                120                125
Glu Asp Leu Met Val Gln Ile His Ser Ile Leu Ala Lys Ile Gly Pro 
     130                135                140
Lys Asp Lys Lys Phe Gly Val Lys Ala Arg Ile Asn Gly Ala Leu Asn 
 145                150                155                160
Ile Thr Leu Asn Leu Val Lys Gln Asn Leu Gln Asn His Arg Leu Val 
                 165                170                175
Leu Pro Cys Leu Gln Leu Leu Arg Val Tyr Ser Ala Asn Ser Val Asn 
             180                185                190
Ser Val Ser Leu Gly Lys Asn Gly Val Val Glu Leu Met Phe Lys Ile 
         195                200                205
Ile Gly Pro Phe Ser Lys Lys Asn Ser Ser Leu Ile Lys Val Ala Leu 
     210                215                220
Asp Thr Leu Ala Ala Leu Leu Lys Ser Lys Thr Asn Ala Arg Arg Ala 
 225                230                235                240
Val Asp Arg Gly Tyr Val Gln Val Leu Leu Thr Ile Tyr Val Asp Trp 
                 245                250                255
His Arg His Asp Asn Arg His Arg Asn Met Leu Ile Arg Lys Gly Ile 
             260                265                270
Leu Gln Ser Leu Lys Ser Val Thr Asn Ile Lys Leu Gly Arg Lys Ala 
         275                280                285
Phe Ile Asp Ala Asn Gly Met Lys Ile Leu Tyr Asn Thr Ser Gln Leu 
     290                295                300
Pro Val Ile Pro Val Thr Gly Pro Val Ala Gln Leu Tyr Ser Leu Pro 
 305                310                315                320
Pro Glu Val Asp Asp Val Val Asp Glu Ser Asp Asp Asn Asp Asp Ile 
                 325                330                335
Asp Val Glu Ala Glu Asn Glu Thr Glu Asn Glu Asp Asp Leu Asp Gln 
             340                345                350
Asn Phe Lys Asn Asp Asp Ile Glu Thr Asp Ile Asn Lys Leu Lys Pro 
         355                360                365
Gln Gln Glu Pro Gly Arg Thr Ile Glu Asp Leu Lys Met Tyr Glu His 
     370                375                380
Leu Phe Pro Glu Leu Val Asp Asp Phe Gln Asp Tyr Asp Leu Ile Ser 
 385                390                395                400
Lys Glu Pro Lys Pro Phe Val Phe Glu Gly Lys Val Arg Gly Pro Ile 
                 405                410                415
Val Val Pro Thr Ala Gly Glu Glu Thr Ser Gly Asn Ser Gly Asn Leu 
             420                425                430
Arg Lys Val Val Met Lys Glu Asn Ile Ser Ser Lys Gly Asp Glu Gly 
         435                440                445
Glu Lys Lys Ser Thr Phe Met Asp Leu Ala Lys Glu Asp Ile Lys Asp 
     450                455                460
Asn Asp Arg Thr Leu Gln Gln Gln Pro Gly Asp Gln Asn Arg Thr Ile 
 465                470                475                480
Ser Ser Val His Gly Leu Asn Asn Asp Ile Val Lys Ala Leu Asp Arg 
                 485                490                495
Ile Thr Leu Gln Asn Ile Pro Ser Gln Thr Ala Pro Gly Phe Thr Ala 
             500                505                510
Glu Met Lys Lys Asp Cys Ser Leu Pro Leu Thr Val Leu Thr Cys Ala 
         515                520                525
Lys Ala Cys Pro His Met Ala Thr Cys Gly Asn Val Leu Phe Glu Gly 
     530                535                540
Arg Thr Val Gln Leu Gly Lys Leu Cys Cys Thr Gly Val Glu Thr Glu 
 545                550                555                560
Asp Asp Glu Asp Thr Glu Ser Asn Ser Ser Val Glu Gln Ala Ser Val 
                 565                570                575
Glu Val Pro Asp Gly Pro Thr Leu His Asp Pro Asp Leu Tyr Ile Glu 
             580                585                590
Ile Val Lys Asn Thr Lys Ser Val Pro Glu Tyr Ser Glu Val Ala Tyr 
         595                600                605
Pro Asp Tyr Phe Gly His Ile Pro Pro Pro Phe Lys Glu Pro Ile Leu 
     610                615                620
Glu Arg Pro Tyr Gly Val Gln Arg Thr Lys Ile Ala Gln Asp Ile Glu 
 625                630                635                640
Arg Leu Ile His Gln Ser Asp Ile Ile Asp Arg Val Val Tyr Asp Leu 
                 645                650                655
Asp Asn Pro Asn Tyr Thr Ile Pro Glu Glu Gly Asp Ile Leu Lys Phe 
             660                665                670
Asn Ser Lys Phe Glu Ser Gly Asn Leu Arg Lys Val Ile Gln Ile Arg 
         675                680                685
Lys Asn Glu Tyr Asp Leu Ile Leu Asn Ser Asp Ile Asn Ser Asn His 
     690                695                700
Tyr His Gln Trp Phe Tyr Phe Glu Val Ser Gly Met Arg Pro Gly Val 
 705                710                715                720
Ala Tyr Arg Phe Asn Ile Ile Asn Cys Glu Lys Ser Asn Ser Gln Phe 
                 725                730                735
Asn Tyr Gly Met Gln Pro Leu Met Tyr Ser Val Gln Glu Ala Leu Asn 
             740                745                750
Ala Arg Pro Trp Trp Ile Arg Met Gly Thr Asp Ile Cys Tyr Tyr Lys 
         755                760                765
Asn His Phe Ser Arg Ser Ser Val Ala Ala Gly Gly Gln Lys Gly Lys 
     770                775                780
Ser Tyr Tyr Thr Ile Thr Phe Thr Val Asn Phe Pro His Lys Asp Asp 
 785                790                795                800
Val Cys Tyr Phe Ala Tyr His Tyr Pro Tyr Thr Tyr Ser Thr Leu Gln 
                 805                810                815
Met His Leu Gln Lys Leu Glu Ser Ala His Asn Pro Gln Gln Ile Tyr 
             820                825                830
Phe Arg Lys Asp Val Leu Cys Glu Thr Leu Ser Gly Asn Ser Cys Pro 
         835                840                845
Leu Val Thr Ile Thr Ala Met Pro Glu Ser Asn Tyr Tyr Glu His Ile 
     850                855                860
Cys His Phe Arg Asn Arg Pro Tyr Val Phe Leu Ser Ala Arg Val His 
 865                870                875                880
Pro Gly Glu Thr Asn Ala Ser Trp Val Met Lys Gly Thr Leu Glu Tyr 
                 885                890                895
Leu Met Ser Asn Asn Pro Thr Ala Gln Ser Leu Arg Glu Ser Tyr Ile 
             900                905                910
Phe Lys Ile Val Pro Met Leu Asn Pro Asp Gly Val Ile Asn Gly Asn 
         915                920                925
His Arg Cys Ser Leu Ser Gly Glu Asp Leu Asn Arg Gln Trp Gln Ser 
     930                935                940
Pro Ser Pro Asp Leu His Pro Thr Ile Tyr His Ala Lys Gly Leu Leu 
 945                950                955                960
Gln Tyr Leu Ala Ala Val Lys Arg Leu Pro Leu Val Tyr Cys Asp Tyr 
                 965                970                975
His Gly His Ser Arg Lys Lys Asn Val Phe Met Tyr Gly Cys Ser Ile 
             980                985                990
Lys Glu Thr Val Trp His Thr Asn Asp Asn Ala Thr Ser Cys Asp Val 
         995                1000                1005
Val Glu Asp Thr Gly Tyr Arg Thr Leu Pro Lys Ile Leu Ser His Ile 
     1010                1015                1020
Ala Pro Ala Phe Cys Met Ser Ser Cys Ser Phe Val Val Glu Lys Ser 
 1025                1030                1035                1040
Lys Glu Ser Thr Ala Arg Val Val Val Trp Arg Glu Ile Gly Val Gln 
                 1045                1050                1055
Arg Ser Tyr Thr Met Glu Ser Thr Leu Cys Gly Cys Asp Gln Gly Lys 
             1060                1065                1070
Tyr Lys Gly Leu Gln Ile Gly Thr Arg Glu Leu Glu Glu Met Gly Ala 
         1075                1080                1085
Lys Phe Cys Val Gly Leu Leu Arg Leu Lys Arg Leu Thr Ser Pro Leu 
     1090                1095                1100
Glu Tyr Asn Leu Pro Ser Ser Leu Leu Asp Phe Glu Asn Asp Leu Ile 
 1105                1110                1115                1120
Glu Ser Ser Cys Lys Val Thr Ser Pro Thr Thr Tyr Val Leu Asp Glu 
                 1125                1130                1135
Asp Glu Pro Arg Phe Leu Glu Glu Val Asp Tyr Ser Ala Glu Ser Asn 
             1140                1145                1150
Asp Glu Leu Asp Ile Glu Leu Ala Glu Asn Val Gly Asp Tyr Glu Pro 
         1155                1160                1165
Ser Ala Gln Glu Glu Val Leu Ser Asp Ser Glu Leu Ser Arg Thr Tyr 
     1170                1175                1180
Leu Pro 
 1185



<210> 5630
<211> 614
<212> DNA
<213> Rattus norvegicus
<308> AA891872
<400> 5630

gagaacatg  tgaactcat  tattactca  atggttgca  tccattcaa  agcacttaa  60
acagaccat  caagagcac  taattgatt  aaattaaag  gaccaattg  catgggact  120
ttaaaaata  aacttattc  ttttaagtt  ttacttaaa  tatctagat  ttctacata  180
taaaataga  gtgagaaaa  agatctttg  aatctagag  ctagagtga  ggctaaaaa  240
ctgatatgg  attggcatg  tcaatccag  ctacggcta  aatgcaaga  aacaggtca  300
gagttgatc  aagtttcaa  atttgtcac  tttggtgga  aaataaaac  ctaaatgca  360
gtgcctgtg  tgatcaaac  gcataatat  cttcagacc  aaacatatc  tgaaatctt  420
aacattcaa  ttctgagct  atttctagc  cccgaaagg  ggttgcaaa  tccaatggg  480
ttgcatcta  agtgaggcc  ctctctcac  gctgacaaa  tactctgct  tttggcaat  540
gcaatgata  acaagtaga  gatgagaac  cccgatgct  tttgagaat  aagggttgc  600
gatcttgaa  atct  614



<210> 5631
<211> 1086
<212> PRT
<213> Rattus norvegicus
<308> Q61941
<400> 5631

Met Ala His Leu Leu Lys Thr Val Val Ala Gly Cys Ser Cys Pro Phe 
  1               5                  10                  15
Leu Ser Asn Leu Gly Ser Ser Lys Val Leu Pro Gly Lys Arg Asp Phe 
             20                  25                  30
Val Arg Met Leu Arg Thr His Gln Ala Leu Trp Cys Lys Ser Pro Val 
         35                  40                  45
Lys Pro Gly Ile Pro Tyr Lys Gln Leu Thr Val Gly Val Pro Lys Glu 
     50                  55                  60
Ile Phe Gln Asn Glu Lys Arg Val Ala Leu Ser Pro Ala Gly Val Gln 
 65                  70                  75                  80
Ala Leu Val Lys Gln Gly Phe Asn Val Val Val Glu Ser Gly Ala Gly 
                 85                  90                  95
Glu Ala Ser Lys Phe Pro Asp Asp Leu Tyr Arg Ala Ala Gly Ala Gln 
             100                105                110
Ile Gln Gly Met Lys Glu Val Leu Ala Ser Asp Leu Val Val Lys Val 
         115                120                125
Arg Ala Pro Met Val Asn Pro Thr Leu Gly Ala His Glu Ala Asp Phe 
     130                135                140
Leu Lys Pro Ser Gly Thr Leu Ile Ser Phe Ile Tyr Pro Ala Gln Asn 
 145                150                155                160
Pro Asp Leu Leu Asn Lys Leu Ser Glu Arg Lys Thr Thr Val Leu Ala 
                 165                170                175
Met Asp Gln Val Pro Arg Val Thr Ile Ala Gln Gly Tyr Asp Ala Leu 
             180                185                190
Ser Ser Met Ala Asn Ile Ser Gly Tyr Lys Ala Val Val Leu Ala Ala 
         195                200                205
Asn His Phe Gly Arg Phe Phe Thr Gly Gln Ile Thr Ala Ala Gly Lys 
     210                215                220
Val Pro Pro Ala Lys Ile Leu Ile Val Gly Gly Gly Val Ala Gly Leu 
 225                230                235                240
Ala Ser Ala Gly Ala Ala Lys Ser Met Gly Ala Val Val Arg Gly Phe 
                 245                250                255
Asp Thr Arg Ala Ala Ala Leu Glu Gln Phe Lys Ser Leu Gly Ala Glu 
             260                265                270
Pro Leu Glu Val Asp Leu Lys Glu Ser Gly Glu Gly Gln Gly Gly Tyr 
         275                280                285
Ala Lys Glu Met Ser Lys Glu Phe Ile Glu Ala Glu Met Lys Leu Phe 
     290                295                300
Ala Gln Gln Cys Lys Glu Val Asp Ile Leu Ile Ser Thr Ala Leu Ile 
 305                310                315                320
Pro Gly Lys Lys Ala Pro Val Leu Phe Ser Lys Glu Met Ile Glu Ser 
                 325                330                335
Met Lys Glu Gly Ser Val Val Val Asp Leu Ala Ala Glu Ala Gly Gly 
             340                345                350
Asn Phe Glu Thr Thr Lys Pro Gly Glu Leu Tyr Val His Lys Gly Ile 
         355                360                365
Thr His Ile Gly Tyr Thr Asp Leu Pro Ser Arg Met Ala Thr Gln Ala 
     370                375                380
Ser Thr Leu Tyr Ser Asn Asn Ile Thr Lys Leu Leu Lys Ala Ile Ser 
 385                390                395                400
Pro Asp Lys Asp Asn Phe His Phe Glu Val Lys Asp Asp Phe Asp Phe 
                 405                410                415
Gly Thr Met Ser His Val Ile Arg Gly Thr Val Val Met Lys Asp Gly 
             420                425                430
Lys Val Ile Phe Pro Ala Pro Thr Pro Lys Asn Ile Pro Glu Glu Ala 
         435                440                445
Pro Val Lys Pro Lys Thr Val Ala Glu Leu Glu Ala Glu Lys Ala Gly 
     450                455                460
Thr Val Ser Met Tyr Thr Lys Thr Leu Thr Thr Ala Ser Val Tyr Ser 
 465                470                475                480
Ala Gly Leu Thr Gly Met Leu Gly Leu Gly Ile Val Ala Pro Asn Val 
                 485                490                495
Ala Phe Ser Gln Met Val Thr Thr Phe Gly Leu Ala Gly Ile Ile Gly 
             500                505                510
Tyr His Thr Val Trp Gly Val Thr Pro Ala Leu His Ser Pro Leu Met 
         515                520                525
Ser Val Thr Asn Ala Ile Ser Gly Leu Thr Ala Val Gly Gly Leu Ala 
     530                535                540
Leu Met Gly Gly His Phe Tyr Pro Ser Thr Thr Ser Gln Ser Leu Ala 
 545                550                555                560
Ala Leu Ala Thr Phe Ile Ser Ser Val Asn Ile Ala Gly Gly Phe Leu 
                 565                570                575
Val Thr Gln Arg Met Leu Asp Met Phe Lys Arg Pro Thr Asp Pro Pro 
             580                585                590
Glu Tyr Asn Tyr Leu Tyr Leu Leu Pro Gly Gly Thr Phe Val Gly Gly 
         595                600                605
Tyr Leu Ala Ala Leu Tyr Gly Gly Tyr Asn Ile Glu Glu Ile Met Tyr 
     610                615                620
Leu Gly Ser Gly Leu Cys Cys Val Gly Ala Leu Gly Gly Leu Ser Thr 
 625                630                635                640
Gln Gly Thr Ala Arg Leu Gly Asn Ala Leu Gly Met Ile Gly Val Ala 
                 645                650                655
Gly Gly Leu Ala Ala Thr Leu Gly Gly Leu Lys Pro Asp Pro Gln Leu 
             660                665                670
Leu Ala Gln Met Ser Gly Ala Met Ala Met Gly Gly Thr Ile Gly Leu 
         675                680                685
Thr Ile Ala Lys Arg Ile Gln Ile Ser Asp Leu Pro Gln Leu Val Ala 
     690                695                700
Ala Phe His Ser Leu Val Gly Leu Ala Ala Val Leu Thr Cys Met Ala 
 705                710                715                720
Glu Tyr Ile Val Glu Tyr Pro His Phe Ala Met Asp Ala Thr Ser Asn 
                 725                730                735
Phe Thr Lys Ile Val Ala Tyr Leu Gly Thr Tyr Ile Gly Gly Val Thr 
             740                745                750
Phe Ser Gly Ser Leu Val Ala Tyr Gly Lys Leu Gln Gly Ile Leu Lys 
         755                760                765
Ser Ala Pro Leu Leu Leu Leu Gly Arg His Ala Leu Asn Ala Gly Leu 
     770                775                780
Leu Ala Ala Ser Val Gly Gly Ile Ile Pro Phe Met Ala Asp Pro Ser 
 785                790                795                800
Phe Thr Thr Gly Ile Thr Cys Leu Gly Ser Val Ser Ala Leu Ser Thr 
                 805                810                815
Leu Met Gly Val Thr Leu Thr Ala Ala Ile Gly Gly Ala Asp Met Pro 
             820                825                830
Val Val Ile Thr Val Leu Asn Ser Tyr Ser Gly Trp Ala Leu Cys Ala 
         835                840                845
Glu Gly Phe Leu Leu Asn Asn Asn Leu Leu Thr Ile Val Gly Ala Leu 
     850                855                860
Ile Gly Ser Ser Gly Ala Ile Leu Ser Tyr Ile Met Cys Val Ala Met 
 865                870                875                880
Asn Arg Ser Leu Ala Asn Val Ile Leu Gly Gly Tyr Gly Thr Thr Ser 
                 885                890                895
Thr Ala Gly Gly Lys Pro Met Glu Ile Ser Gly Thr His Thr Glu Ile 
             900                905                910
Asn Leu Asp Asn Ala Val Glu Met Ile Arg Glu Ala Asn Ser Ile Val 
         915                920                925
Ile Thr Pro Gly Tyr Gly Leu Cys Ala Ala Lys Ala Gln Tyr Pro Ile 
     930                935                940
Ala Asp Leu Val Lys Met Leu Thr Glu Gln Gly Lys Lys Val Arg Phe 
 945                950                955                960
Gly Ile His Pro Val Ala Gly Arg Met Pro Gly Gln Leu Asn Val Leu 
                 965                970                975
Leu Ala Glu Ala Gly Val Pro Tyr Asp Ile Val Leu Glu Met Asp Glu 
             980                985                990
Ile Asn Ser Asp Phe Pro Asp Thr Asp Leu Val Leu Val Ile Gly Ala 
         995                1000                1005
Asn Asp Thr Val Asn Ser Ala Ala Gln Glu Asp Pro Asn Ser Ile Ile 
     1010                1015                1020
Ala Gly Met Pro Val Leu Glu Val Trp Lys Ser Lys Gln Val Ile Val 
 1025                1030                1035                1040
Met Lys Arg Ser Leu Gly Val Gly Tyr Ala Ala Val Asp Asn Pro Ile 
                 1045                1050                1055
Phe Tyr Lys Pro Asn Thr Ala Met Leu Leu Gly Asp Ala Lys Lys Thr 
             1060                1065                1070
Cys Asp Ala Leu Gln Ala Lys Val Arg Glu Ser Tyr Gln Lys 
         1075                1080                1085



<210> 5632
<211> 4232
<212> DNA
<213> Homo sapiens
<308> U40490
<400> 5632

gcgccgcgg  gcccaagcc  gggtctgcc  gcgcgagct  ctctcgcgg  cctcagggc  60
cagcccaag  ctgtcagcc  cccggccca  tgatttgcc  tcaaggaaa  tggggagtc  120
gaaaattgg  aactcatat  aacatggca  acctattga  aacagtggt  actggctgc  180
cgtgtcctc  acttagcaa  ttggggtcc  gtaagggtc  acgtgtgaa  aaggatttt  240
tacgaacat  ttatactca  caagaactg  ggtgtaaag  gcctgtaaa  ccaggaatt  300
catataagc  actgactgt  ggagtcccc  aagagatat  ccaaaatga  aagcgagtg  360
cattgtctc  tgctggtgt  cagaacttg  tcaagcagg  ttttaatgt  gtcgtggaa  420
cgggtgcgg  cgaagcttc  aagttctca  atgatcact  tagagtggc  ggtgcccaa  480
tccaagggg  aaaggaagt  ctggcttct  atttggtgg  caaagtgcg  gcccctatg  540
ttaatccaa  attaggtgt  catgaagct  accttttaa  gacatcagg  acgctgatt  600
gttttattt  cccagccca  aatccagag  tgctaaata  actttccca  agaaaaact  660
cagttctgg  aatggacca  gttccaaga  tcacaattg  tcagggata  gatgcgcta  720
gctccatgg  caacattgc  ggttataag  ctgttgtcc  agcagcaaa  cattttgga  780
gttttttta  tggtcagat  acagctgct  gaaaagttc  tccagctaa  attctgata  840
ttggtggtg  tgttgctgg  cttgcttct  caggcgccg  aaagtcgat  ggtgcaatt  900
ttcgaggat  tgacacaag  gctgccagt  tggaacagt  caagtctct  ggtgctgag  960
ccttggagg  ggacttgaa  gaatctggt  agggacaag  aggatatgc  aaagagatg  1020
ccaaagagt  cattgaagc  gaaatgaaa  tctttgctc  acaatgcaa  gaggtagac  1080
tccttatca  cacagcact  attccaggt  aaaaagctc  agttttatt  aataaagaa  1140
tgattgagt  aatgaagga  ggttcagtt  ttgtggatt  agctgctga  gctggtgga  1200
actttgaaa  cactaagcc  ggagaactc  acattcata  gggaattac  cacataggc  1260
acacagacc  gcccagccg  atggccact  aggccagca  cctatattc  aacaacatc  1320
ccaaactcc  gaaggccat  agcccggac  aagataatt  ttattttga  gtgaaagat  1380
actttgact  tggtacgat  ggtcatgtc  ttagaggaa  tgtagtgat  aaagatggt  1440
aagtgattt  cccagctcc  acaccgaaa  atattcctc  aggtgcccc  gtaaaacag  1500
agacagtgg  tgagctgga  gctgaaaaa  cagctacca  tacaccctt  aggaagaca  1560
tgtcaacgg  ttctgcata  acagcaggt  tcacaggga  actgggttt  ggcattgcg  1620
ctcccaatc  agccttttc  cagatggtg  ccacttttg  cttggctgg  attgtgggg  1680
atcataccg  ctggggagt  acccctgct  tccactcac  actgatgtc  gtgacaaat  1740
caatctcag  gctgactgc  gttggtggg  tggcactga  gggaggaca  ttgtatcct  1800
ccacaactt  tcagggcct  gctgctctt  ctgcattca  atcctctgt  aacattgca  1860
gtggctttc  ggtgactca  agaatgctg  acatgttca  gcgtcccac  gacccccca  1920
aatacaact  cctgtacct  ctccctgcc  gcacctttg  tggtggata  ttagctgcc  1980
tctacagtg  ttataacat  gaacagatc  tgtacctag  ctcgggttt  tgctgtgtc  2040
gtgccttgg  tggcctctc  acccaggga  cagcacgtc  tggcaatgc  ctgggcatg  2100
ttggggttg  tggaggact  gcagccacc  tcggagtcc  aaaaccggg  ccagaatta  2160
tagctcaga  gtctggagc  atggctttg  gtggtacca  tggattgac  attgccaaa  2220
gcatccaga  ttctgattt  cctcaatta  ttgctgctt  acacagttt  gtgggtttg  2280
cagctgtac  tacttgcat  gctgagtac  ttatagaat  tccacattt  gctccggat  2340
cagcagcaa  tctcaccaa  attgtggcc  acctcggca  ttacattgg  ggcgtcacc  2400
ttagtgggt  tctcattgc  tatggaaaa  tgcagggtc  cctgaaatc  gcccctctc  2460
tactgcctg  aaggcactt  ctcaatgca  gcttactgg  tgctagtgt  ggcgggata  2520
tcccattca  ggtggaccc  agctttact  ctggcatca  ctgtctggg  tcagtgtct  2580
ctctctctg  tgtcatggg  gtgactttg  cagctgcta  tgggggtgc  gacatgccc  2640
tcgttatca  tgtgctgaa  agctactca  gctgggccc  gtgtgcaga  ggcttcctg  2700
tcaacaaca  tctgctgac  atcgtgggt  cactcatag  ctcgtctgg  gctcccctg  2760
catacatca  gtgtgtggc  atgaatcgc  ccctggcta  tgtgattct  ggaggctat  2820
gcaccactt  aacagctgg  ggaaaaccc  tggaaattt  tggcacaca  acggaaatc  2880
accttgaca  tgcaattga  atgattcga  aagctaata  cattatttt  acaccaggc  2940
atggtctct  tgcagccaa  gctcaatac  ccattgctg  tttggtaaa  atgctcact  3000
agcaaggca  aaaagtcag  tttggaatt  acccagttg  aggccgaat  cctggtcag  3060
ttaatgtgc  gctggctga  gctggtgtg  catatgaca  tgtgttgga  atggatgag  3120
tcaaccatg  ttttccaga  actgatttg  tccttgtaa  tggagctaa  gacactgtt  3180
attcagcag  tcaagaaga  cccaactct  ttattgcag  catgccagt  cttgaggtc  3240
ggaaatcaa  gcaggtgat  gttatgaag  ggtctttgg  tgttggcta  gctgcagtg  3300
acaatccaa  cttctacaa  cctaacacg  ccatgcttc  aggtgatgc  aagaaaaca  3360
gtgacgcgc  ccaggcgaa  gttagagaa  cctatcaga  gtaaatatt  aggatcaag  3420
tgttagcta  tatgccacc  ctgcagttt  gggaacagg  aaataaagt  tcagtatac  3480
tggtgatgt  catctgtag  aaagctctt  gagcaaaat  aagactgaa  aaagcaaag  3540
aaaaactgt  tagagagat  tttcaaaag  agtaatccc  caattttaa  aaaggattg  3600
aaattctaa  tgtctttct  tgcatattt  ttgtgttag  aatcaaaag  attttataa  3660
aggagaaag  acagcctca  tttagatgt  gtcctgttg  attttttat  cctcctcag  3720
aaccagaaa  gttttaaaa  actaagtgt  taggatttc  agacaacat  atacatggc  3780
ctgaaatat  tgacacaat  taaacattg  aggcacctg  attttatgt  ttttttttc  3840
acaaatgtg  ctaatttga  acttttatg  acttctgag  tgtcccctt  caattcaac  3900
gcagtttga  ttaatcata  caaatcagt  ttaattttt  aaattgtac  tcagagtct  3960
tatttcaag  gcacatttt  tcactacta  tttaataca  taaaggact  aataatctt  4020
cagagatgc  ggaaacaaa  cacttgctt  atatgtttc  ttagaatac  aatgaaaca  4080
acaacttga  aattagtaa  agtattttg  aagatccca  ttctaattg  agatctctt  4140
aatttcgat  aacttataa  gtgtagtac  atattaagt  cacttgagt  ggattcaac  4200
tttgactaa  aaaatgagt  catcatgtt  gc  4232



<210> 5633
<211> 1086
<212> PRT
<213> Homo sapiens
<308> Q13423
<400> 5633

Met Ala Asn Leu Leu Lys Thr Val Val Thr Gly Cys Ser Cys Pro Leu 
  1               5                  10                  15
Leu Ser Asn Leu Gly Ser Cys Lys Gly Leu Arg Val Lys Lys Asp Phe 
             20                  25                  30
Leu Arg Thr Phe Tyr Thr His Gln Glu Leu Trp Cys Lys Ala Pro Val 
         35                  40                  45
Lys Pro Gly Ile Pro Tyr Lys Gln Leu Thr Val Gly Val Pro Lys Glu 
     50                  55                  60
Ile Phe Gln Asn Glu Lys Arg Val Ala Leu Ser Pro Ala Gly Val Gln 
 65                  70                  75                  80
Asn Leu Val Lys Gln Gly Phe Asn Val Val Val Glu Ser Gly Ala Gly 
                 85                  90                  95
Glu Ala Ser Lys Phe Ser Asp Asp His Tyr Arg Val Ala Gly Ala Gln 
             100                105                110
Ile Gln Gly Ala Lys Glu Val Leu Ala Ser Asp Leu Val Val Lys Val 
         115                120                125
Arg Ala Pro Met Val Asn Pro Thr Leu Gly Val His Glu Ala Asp Leu 
     130                135                140
Leu Lys Thr Ser Gly Thr Leu Ile Ser Phe Ile Tyr Pro Ala Gln Asn 
 145                150                155                160
Pro Glu Leu Leu Asn Lys Leu Ser Gln Arg Lys Thr Thr Val Leu Thr 
                 165                170                175
Met Asp Gln Val Pro Arg Val Thr Ile Ala Gln Gly Tyr Asp Ala Leu 
             180                185                190
Ser Ser Met Ala Asn Ile Ala Gly Tyr Lys Ala Val Val Leu Ala Ala 
         195                200                205
Asn His Phe Gly Arg Phe Phe Thr Gly Gln Ile Thr Ala Ala Gly Lys 
     210                215                220
Val Pro Pro Ala Lys Ile Leu Ile Val Gly Gly Gly Val Ala Gly Leu 
 225                230                235                240
Ala Ser Ala Gly Ala Ala Lys Ser Met Gly Ala Ile Val Arg Gly Phe 
                 245                250                255
Asp Thr Arg Ala Ala Ala Leu Glu Gln Phe Lys Ser Leu Gly Ala Glu 
             260                265                270
Pro Leu Glu Val Asp Leu Lys Glu Ser Gly Glu Gly Gln Gly Gly Tyr 
         275                280                285
Ala Lys Glu Met Ser Lys Glu Phe Ile Glu Ala Glu Met Lys Leu Phe 
     290                295                300
Ala Gln Gln Cys Lys Glu Val Asp Ile Leu Ile Ser Thr Ala Leu Ile 
 305                310                315                320
Pro Gly Lys Lys Ala Pro Val Leu Phe Asn Lys Glu Met Ile Glu Ser 
                 325                330                335
Met Lys Glu Gly Ser Val Val Val Asp Leu Ala Ala Glu Ala Gly Gly 
             340                345                350
Asn Phe Glu Thr Thr Lys Pro Gly Glu Leu Tyr Ile His Lys Gly Ile 
         355                360                365
Thr His Ile Gly Tyr Thr Asp Leu Pro Ser Arg Met Ala Thr Gln Ala 
     370                375                380
Ser Xaa Leu Tyr Ser Asn Asn Ile Thr Lys Leu Leu Lys Ala Ile Ser 
 385                390                395                400
Pro Asp Lys Asp Asn Phe Tyr Phe Asp Val Lys Asp Asp Phe Asp Phe 
                 405                410                415
Gly Thr Met Gly His Val Ile Arg Gly Thr Val Val Met Lys Asp Gly 
             420                425                430
Lys Val Ile Phe Pro Ala Pro Thr Pro Lys Asn Ile Pro Gln Gly Ala 
         435                440                445
Pro Val Lys Gln Lys Thr Val Ala Glu Leu Glu Ala Glu Lys Ala Ala 
     450                455                460
Thr Ile Thr Pro Phe Arg Lys Thr Met Ser Thr Ala Ser Ala Tyr Thr 
 465                470                475                480
Ala Gly Leu Thr Gly Ile Leu Gly Leu Gly Ile Ala Ala Pro Asn Leu 
                 485                490                495
Ala Phe Ser Gln Met Val Thr Thr Phe Gly Leu Ala Gly Ile Val Gly 
             500                505                510
Tyr His Thr Val Trp Gly Val Thr Pro Ala Leu His Ser Pro Leu Met 
         515                520                525
Ser Val Thr Asn Ala Ile Ser Gly Leu Thr Ala Val Gly Gly Leu Ala 
     530                535                540
Leu Met Gly Gly His Leu Tyr Pro Ser Thr Thr Ser Gln Gly Leu Ala 
 545                550                555                560
Ala Leu Ala Ala Phe Ile Ser Ser Val Asn Ile Ala Gly Gly Phe Leu 
                 565                570                575
Val Thr Gln Arg Met Leu Asp Met Phe Lys Arg Pro Thr Asp Pro Pro 
             580                585                590
Glu Tyr Asn Tyr Leu Tyr Leu Leu Pro Ala Gly Thr Phe Val Gly Gly 
         595                600                605
Tyr Leu Ala Ala Leu Tyr Ser Gly Tyr Asn Ile Glu Gln Ile Met Tyr 
     610                615                620
Leu Gly Ser Gly Leu Cys Cys Val Gly Ala Leu Ala Gly Leu Ser Thr 
 625                630                635                640
Gln Gly Thr Ala Arg Leu Gly Asn Ala Leu Gly Met Ile Gly Val Ala 
                 645                650                655
Gly Gly Leu Ala Ala Thr Leu Gly Val Leu Lys Pro Gly Pro Glu Leu 
             660                665                670
Leu Ala Gln Met Ser Gly Ala Met Ala Leu Gly Gly Thr Ile Gly Leu 
         675                680                685
Thr Ile Ala Lys Arg Ile Gln Ile Ser Asp Leu Pro Gln Leu Val Ala 
     690                695                700
Ala Phe His Ser Leu Val Gly Leu Ala Ala Val Leu Thr Cys Ile Ala 
 705                710                715                720
Glu Tyr Ile Ile Glu Tyr Pro His Phe Ala Thr Asp Ala Ala Ala Asn 
                 725                730                735
Leu Thr Lys Ile Val Ala Tyr Leu Gly Thr Tyr Ile Gly Gly Val Thr 
             740                745                750
Phe Ser Gly Ser Leu Ile Ala Tyr Gly Lys Leu Gln Gly Leu Leu Lys 
         755                760                765
Ser Ala Pro Leu Leu Leu Pro Gly Arg His Leu Leu Asn Ala Gly Leu 
     770                775                780
Leu Ala Ala Ser Val Gly Gly Ile Ile Pro Phe Met Val Asp Pro Ser 
 785                790                795                800
Phe Thr Thr Gly Ile Thr Cys Leu Gly Ala Val Ser Ala Leu Ser Ala 
                 805                810                815
Val Met Gly Val Thr Leu Thr Pro Ala Ile Gly Gly Ala Asp Met Pro 
             820                825                830
Val Val Ile Thr Val Leu Asn Ser Tyr Ser Gly Trp Ala Leu Cys Ala 
         835                840                845
Glu Gly Phe Leu Leu Asn Asn Asn Leu Leu Thr Ile Val Gly Ala Leu 
     850                855                860
Ile Gly Ser Ser Gly Ala Ile Leu Ser Tyr Ile Met Cys Val Ala Met 
 865                870                875                880
Asn Arg Ser Leu Ala Asn Val Ile Leu Gly Gly Tyr Gly Thr Thr Ser 
                 885                890                895
Thr Ala Gly Gly Lys Pro Met Glu Ile Ser Gly Thr His Thr Glu Ile 
             900                905                910
Asn Leu Asp Asn Ala Ile Asp Met Ile Arg Glu Ala Asn Ser Ile Ile 
         915                920                925
Ile Thr Pro Gly Tyr Gly Leu Cys Ala Ala Lys Ala Gln Tyr Pro Ile 
     930                935                940
Ala Asp Leu Val Lys Met Leu Thr Glu Gln Gly Lys Lys Val Arg Phe 
 945                950                955                960
Gly Ile His Pro Val Ala Gly Arg Met Pro Gly Gln Leu Asn Val Leu 
                 965                970                975
Leu Ala Glu Ala Gly Val Pro Tyr Asp Ile Val Leu Glu Met Asp Glu 
             980                985                990
Ile Asn His Asp Phe Pro Asp Thr Asp Leu Val Leu Val Ile Gly Ala 
         995                1000                1005
Asn Asp Thr Val Asn Ser Ala Ala Gln Glu Asp Pro Asn Ser Ile Ile 
     1010                1015                1020
Ala Gly Met Pro Val Leu Glu Val Trp Lys Ser Lys Gln Val Ile Val 
 1025                1030                1035                1040
Met Lys Arg Ser Leu Gly Val Gly Tyr Ala Ala Val Asp Asn Pro Ile 
                 1045                1050                1055
Phe Tyr Lys Pro Asn Thr Ala Met Leu Leu Gly Asp Ala Lys Lys Thr 
             1060                1065                1070
Cys Asp Ala Leu Gln Ala Lys Val Arg Glu Ser Tyr Gln Lys 
         1075                1080                1085



<210> 5634
<211> 548
<212> DNA
<213> Rattus norvegicus
<308> AA891877
<400> 5634

gcaccccta  ccaaacgtt  tattctggg  tttacagat  acacaaaca  ctgtgatgt  60
gcaattatg  ttttaatgg  gatataaaa  ttatcaatg  aaaagaaag  tttatataa  120
attagcaat  gtgattaac  taaaattat  ttttaataa  gtgaaatac  gtgtgttag  180
cctcaaaaa  gaaaccaca  agttccccg  aacctaaaa  gttggaaag  ctccttaaa  240
ttgttttta  ctaccaacg  tttaatact  agtggcatc  ggggggacg  aagaaaata  300
ggagctctt  tcagctatg  tttggagct  tagtaaagc  ctatggtaa  gtcactgtg  360
gaagaacca  aaaattctc  caaaagtac  tccaatagc  taggcaact  agaggctta  420
tattaatag  tcaaagctt  gaaagcagc  gctatcctg  agaattgta  aagatcaat  480
ctgctactc  ttctaaaat  cagacataa  ccaaggatg  cagttctgt  aagtttcag  540
gaaacact  548



<210> 5635
<211> 3436
<212> DNA
<213> Homo sapiens
<308> X77548
<400> 5635

caatcgcga  cctcagtcc  cccaaggtc  cctcggatc  cctggagag  cactcggac  60
tggagcagt  aggagaatg  ataccttcc  agaccagag  ggcagctcc  gtaatagag  120
acccctttt  aggtgtagt  atgcacgga  ggacttgga  cttgctatt  gtggagttc  180
ccgggctga  cagcaaatt  aagataact  gcgagaggt  aaagctcag  ttcacagtt  240
cataagccg  cacctggaa  gtcttagaa  ccgtgaggt  tggctgtat  aacaggtgg  300
ccttattta  cagcttaaa  aggagacac  tcaacagca  gctcagcag  tctactcgt  360
attgggcca  ttcaattgt  ttactcatc  actggagtg  acccaaaac  aagatctag  420
caatcaagt  tctgtgtgc  tggagagac  gggcagttt  acccttaag  ctgaagatt  480
aactgtcct  ctctttgaa  ctgacacaa  tactctgcg  cagaccatc  ccacatttg  540
gtctctcaa  accattcaa  ttcctgagc  cttgatggc  catgctagt  cagcaaata  600
tgggccctt  ctggagaag  gaggctgta  ctccatgcc  gagcagaag  cagcatccg  660
tattgtagc  gtccctttc  gcgaatggc  ccttggaag  aaacctgcc  gtggttatc  720
agctcctta  atacccagc  ccgaccccc  ggactggct  acccaaaag  agaccttgg  780
gaacagtca  acttcttcc  gagcctgca  tttcttcaa  aatgtcggg  gaaacctaa  840
gggcttaga  aactggctc  tcaagagtg  aaaatcaag  tatcaaaag  gtaacagcc  900
ttccactac  agttctttc  ccattgaaa  ggaaaaggt  ggagatcaa  agcttcctg  960
tcaagatga  atggaccta  cagattggc  agtgactcc  caggaatcc  ataagctgc  1020
gaacgctga  aatggcagt  gtgaaacca  tgagaagtt  aagctctta  tccagtcct  1080
taatgtgaa  gattggctt  tcaagactg  ctcctgtac  aactgtcag  gaaaccagc  1140
caaaggtgt  gagattgaa  acctggcca  tctgaagtg  ctgaatgac  acttggagg  1200
caagaaacc  ttgtccacc  ccagcatgg  tacagagga  tggcttgtc  agaaccatc  1260
ggacccatg  aaggtagag  aggtgtgca  agccaatga  ccctgcaca  gctttgcag  1320
gtgtgtgtg  gatgagaat  gtgagaagg  ggctctgta  aagtggctt  tgaagaaag  1380
aggaaagga  aaaaatggg  tgcctgtgg  acccaaacc  gagcctgag  agcataaag  1440
ttccctgaa  atgtggctc  gtcctagaa  agaagtaat  gaacaaact  aagcaccaa  1500
ggcaatgac  ccttctaga  ttgctgatt  cttccaagt  ataaagaac  gccccttgt  1560
ggagtggct  atcaggccc  catacaaag  aggaagtcc  aaggaagtg  ctggtactg  1620
agacagagc  ggcaaacag  agtttaaaa  ccccatgaa  acttcctgg  gttccttta  1680
cacagctga  tgggtcctg  caggaaaga  gatgggcaa  ctcagccag  tatcttctg  1740
agaagacaa  tggctgctt  gaaagaagg  ccaggaagt  ttacttaat  cacctctac  1800
ggaggaaca  aacttcccc  cagaccatt  tggcctccc  gcagtttgt  atctctttg  1860
ctgtatgca  cttaaagtt  ataaagaga  gtggttata  cgaactcct  tacagatgt  1920
aaggaatgg  caagagttg  gcagccttt  tgctgatta  cacacatca  gagctgagt  1980
actgcagct  gccaaatct  tgtgtttct  ggtctgacc  attagctta  ttcttctcc  2040
gcctaattt  gaactagta  agcaaagtg  gtcatcaga  tatgagtta  tgtttaaaa  2100
aaaaatgct  tttattcat  ctgaggtga  tcagttccc  ccttcttac  gaagtattt  2160
aattcaccc  acactagaa  tgcagcatc  ttgtggacg  ctttttcac  agcctccaa  2220
gctccttag  ttgggtcgt  actaaaagt  cattaaaac  ctcttgttt  tcgaagtat  2280
ttgatgtat  ctaaagcta  taaacttcc  taacgttta  ttgccctac  gatgcttct  2340
ttgctgtgg  ttttctttt  ttagtggtc  gaaataatt  ttttcctgt  ctattaata  2400
atagtgtat  ttgcacaaa  aaattaacc  ggtcaatag  gattaccaa  atatatatt  2460
ataatcttg  caatttttg  cattaatta  gaaacattt  agcccacgt  agttctaca  2520
tattcttca  ttaaactca  ctactgcaa  ttttgtctt  ctgtaaatg  tattaaaat  2580
tccagtgag  tctttagaa  gactcagta  tatttcaag  ctatttttg  ggtaattct  2640
gccttttaa  atattctac  gacctacgg  gcttaaaag  accccagta  cgactaagc  2700
aataggcaa  agacatgtt  gaaatgtag  atagtactt  aaacagtca  tatcatagg  2760
ataattggt  catcctgtg  aaatggaag  tgagcttga  acctggtgc  tttaagtag  2820
gataaagtc  tcctctcac  gcaagcaca  catacctgt  cctccaaaa  tgacgtttt  2880
gtgaacagg  cgttttcaa  acttgtgcc  tggggtgtt  attgaagct  tgtgaaaac  2940
actgatgtt  tctcagtct  cttaaagtt  cgtccatgc  ttaaaatgt  tgtgtagga  3000
agaagtggg  tttataatg  tttctctaa  atatctttg  tgctttcca  actttgaaa  3060
tattaagct  tccaactgc  tcttaccgg  aatacttct  ggggaactt  atggtccca  3120
aatgtcatt  ccatacagc  tcaccagag  tctttgaac  acagctgaa  agagctttg  3180
attattttt  aattccctc  ccagatatc  tttaggagt  ttatataaa  gtggtgggc  3240
aaaacaatg  aaggagcct  tccagttat  ttgagttgc  gctctgtag  ttcttgagg  3300
caaacacac  gtatttgtc  aaatataat  tcccttaat  actatgtta  tgagtatgt  3360
aaacattct  ttgcattga  gaattttgt  tctgcttcc  ttaaagcat  acagccata  3420
aaaaaaaaa  aaaaaa  3436



<210> 5636
<211> 614
<212> PRT
<213> Homo sapiens
<308> Q13772
<400> 5636

Met Asn Thr Phe Gln Asp Gln Ser Gly Ser Ser Ser Asn Arg Glu Pro 
  1               5                  10                  15
Leu Leu Arg Cys Ser Asp Ala Arg Arg Asp Leu Glu Leu Ala Ile Gly 
             20                  25                  30
Gly Val Leu Arg Ala Glu Gln Gln Ile Lys Asp Asn Leu Arg Glu Val 
         35                  40                  45
Lys Ala Gln Ile His Ser Cys Ile Ser Arg His Leu Glu Cys Leu Arg 
     50                  55                  60
Ser Arg Glu Val Trp Leu Tyr Glu Gln Val Asp Leu Ile Tyr Gln Leu 
 65                  70                  75                  80
Lys Glu Glu Thr Leu Gln Gln Gln Ala Gln Gln Leu Tyr Ser Leu Leu 
                 85                  90                  95
Gly Gln Phe Asn Cys Leu Thr His Gln Leu Glu Cys Thr Gln Asn Lys 
             100                105                110
Asp Leu Ala Asn Gln Val Ser Val Cys Leu Glu Arg Leu Gly Ser Leu 
         115                120                125
Thr Leu Lys Pro Glu Asp Ser Thr Val Leu Leu Phe Glu Ala Asp Thr 
     130                135                140
Ile Thr Leu Arg Gln Thr Ile Thr Thr Phe Gly Ser Leu Lys Thr Ile 
 145                150                155                160
Gln Ile Pro Glu His Leu Met Ala His Ala Ser Ser Ala Asn Ile Gly 
                 165                170                175
Pro Phe Leu Glu Lys Arg Gly Cys Ile Ser Met Pro Glu Gln Lys Ser 
             180                185                190
Ala Ser Gly Ile Val Ala Val Pro Phe Ser Glu Trp Leu Leu Gly Ser 
         195                200                205
Lys Pro Ala Ser Gly Tyr Gln Ala Pro Tyr Ile Pro Ser Thr Asp Pro 
     210                215                220
Gln Asp Trp Leu Thr Gln Lys Gln Thr Leu Glu Asn Ser Gln Thr Ser 
 225                230                235                240
Ser Arg Ala Cys Asn Phe Phe Asn Asn Val Gly Gly Asn Leu Lys Gly 
                 245                250                255
Leu Glu Asn Trp Leu Leu Lys Ser Glu Lys Ser Ser Tyr Gln Lys Cys 
             260                265                270
Asn Ser His Ser Thr Thr Ser Ser Phe Ser Ile Glu Met Glu Lys Val 
         275                280                285
Gly Asp Gln Glu Leu Pro Asp Gln Asp Glu Met Asp Leu Ser Asp Trp 
     290                295                300
Leu Val Thr Pro Gln Glu Ser His Lys Leu Arg Lys Pro Glu Asn Gly 
 305                310                315                320
Ser Arg Glu Thr Ser Glu Lys Phe Lys Leu Leu Phe Gln Ser Tyr Asn 
                 325                330                335
Val Asn Asp Trp Leu Val Lys Thr Asp Ser Cys Thr Asn Cys Gln Gly 
             340                345                350
Asn Gln Pro Lys Gly Val Glu Ile Glu Asn Leu Gly Asn Leu Lys Cys 
         355                360                365
Leu Asn Asp His Leu Glu Ala Lys Lys Pro Leu Ser Thr Pro Ser Met 
     370                375                380
Val Thr Glu Asp Trp Leu Val Gln Asn His Gln Asp Pro Cys Lys Val 
 385                390                395                400
Glu Glu Val Cys Arg Ala Asn Glu Pro Cys Thr Ser Phe Ala Glu Cys 
                 405                410                415
Val Cys Asp Glu Asn Cys Glu Lys Glu Ala Leu Tyr Lys Trp Leu Leu 
             420                425                430
Lys Lys Glu Gly Lys Asp Lys Asn Gly Met Pro Val Glu Pro Lys Pro 
         435                440                445
Glu Pro Glu Lys His Lys Asp Ser Leu Asn Met Trp Leu Cys Pro Arg 
     450                455                460
Lys Glu Val Ile Glu Gln Thr Lys Ala Pro Lys Ala Met Thr Pro Ser 
 465                470                475                480
Arg Ile Ala Asp Ser Phe Gln Val Ile Lys Asn Ser Pro Leu Ser Glu 
                 485                490                495
Trp Leu Ile Arg Pro Pro Tyr Lys Glu Gly Ser Pro Lys Glu Val Pro 
             500                505                510
Gly Thr Glu Asp Arg Ala Gly Lys Gln Lys Phe Lys Ser Pro Met Asn 
         515                520                525
Thr Ser Trp Cys Ser Phe Asn Thr Ala Asp Trp Val Leu Pro Gly Lys 
     530                535                540
Lys Met Gly Asn Leu Ser Gln Leu Ser Ser Gly Glu Asp Lys Trp Leu 
 545                550                555                560
Leu Arg Lys Lys Ala Gln Glu Val Leu Leu Asn Ser Pro Leu Gln Glu 
                 565                570                575
Glu His Asn Phe Pro Pro Asp His Tyr Gly Leu Pro Ala Val Cys Asp 
             580                585                590
Leu Phe Ala Cys Met Gln Leu Lys Val Asp Lys Glu Lys Trp Leu Tyr 
         595                600                605
Arg Thr Pro Leu Gln Met 
     610



<210> 5637
<211> 452
<212> DNA
<213> Rattus norvegicus
<308> AA891880
<400> 5637

agacaggac  gcagtttat  gacaccatg  catgacacc  gttgtcact  gaggagggg  60
tgagtgaaa  tggtctccg  ggatatcac  ggggacccc  ttcgccttt  agctagagg  120
catggattt  gagtgcaga  ataattcta  acactggag  cattaccac  catgccatt  180
ctaaaccca  cttccattt  gtccagcta  gaaggcctg  gtccctcct  tttttgaag  240
gcagaggga  cacagggcc  tccatgtct  aggaacaag  agggctgct  gcaatggtg  300
tatatgcct  taatcccag  actcactgt  ttaggcaat  agatctctg  gttccagga  360
agccagggc  acatagaga  accatattt  aaaaacaaa  tcaaaatag  aagaaagag  420
caggaagga  ggaagaggg  gcactgggg  tg  452



<210> 5638
<211> 321
<212> PRT
<213> Rattus norvegicus
<308> Q9JHY2
<400> 5638

Met Gly Asp Leu Pro Leu Asn Ile Asn Ile Gln Glu Pro Arg Trp Asp 
  1               5                  10                  15
Gln Ser Thr Phe Leu Gly Arg Ala Arg His Phe Phe Thr Val Thr Asp 
             20                  25                  30
Pro Arg Asn Leu Leu Leu Ser Gly Lys Gln Leu Glu Ala Ser Arg Asn 
         35                  40                  45
Ile Val Gln Asn Tyr Arg Ala Gly Val Val Thr Pro Gly Leu Thr Glu 
     50                  55                  60
Asp Gln Leu Trp Arg Ala Lys Tyr Val Tyr Asp Ser Ala Phe His Pro 
 65                  70                  75                  80
Asp Thr Gly Glu Lys Val Val Leu Ile Gly Arg Met Ser Ala Gln Val 
                 85                  90                  95
Pro Met Asn Met Thr Ile Thr Gly Cys Met Leu Thr Phe Tyr Arg Lys 
             100                105                110
Thr Pro Thr Val Val Phe Trp Gln Trp Val Asn Gln Ser Phe Asn Ala 
         115                120                125
Ile Val Asn Tyr Ser Asn Arg Ser Gly Asp Ala Pro Ile Thr Val Gln 
     130                135                140
Gln Leu Gly Thr Ala Tyr Val Ser Ala Thr Thr Gly Ala Val Ala Thr 
 145                150                155                160
Ala Leu Gly Leu Lys Ser Leu Thr Lys His Leu Pro Pro Leu Val Gly 
                 165                170                175
Arg Phe Val Pro Phe Ala Ala Val Ala Ala Ala Asn Cys Ile Asn Ile 
             180                185                190
Pro Leu Met Arg Gln Arg Glu Leu Gln Val Gly Ile Pro Val Thr Asp 
         195                200                205
Glu Ala Gly Gln Arg Leu Gly His Ser Val Thr Ala Ala Lys Gln Gly 
     210                215                220
Ile Phe Gln Val Val Val Ser Arg Ile Gly Met Ala Ile Pro Ala Met 
 225                230                235                240
Ala Ile Pro Pro Val Ile Met Asn Thr Leu Glu Lys Lys Asp Phe Leu 
                 245                250                255
Lys Arg Arg Pro Trp Leu Gly Ala Pro Leu Gln Val Gly Leu Val Gly 
             260                265                270
Phe Cys Leu Val Phe Ala Thr Pro Leu Cys Cys Ala Leu Phe Pro Gln 
         275                280                285
Arg Ser Ser Ile His Val Thr Arg Leu Glu Pro Glu Leu Arg Ala Gln 
     290                295                300
Ile Gln Ala Gln Lys Pro Ser Ile Asp Val Val Tyr Tyr Asn Lys Gly 
 305                310                315                320
Leu 
                 325



<210> 5639
<211> 2735
<212> DNA
<213> Homo sapiens
<308> BC000124
<400> 5639

ggagggccc  gcggcgaca  cggaggcag  gaggaaggc  gttctgaga  cttcagaga  60
cgatggaaa  caaaatggg  gaattgcct  tagacatca  catccagga  cctcgctgg  120
accaaagta  tttcctggg  agagcccgg  actttttca  tgttactga  cctcgaaat  180
tgctgctgt  cggggcaca  ctggaagct  ctcggaaca  cgtgcagaa  tacagggcc  240
gcgtggtga  cccagggat  accgaggac  agctgtgga  ggccaagta  gtgtatgac  300
ccgccttcc  tccggacac  ggggagaag  tggtcctga  tggccgcat  tcagcccag  360
tgcccatga  catgaccat  actggctgc  tgctcacat  ctacaggaa  accccaacc  420
tggtgttct  gcagtgggt  aatcagtcc  tcaatgcca  tgttaacta  tccaaccgc  480
gtggtgaca  tcccatcac  gtgaggcag  tggggacag  ctatgtgag  gccaccact  540
gagctgtgg  cacggccct  ggactcaaa  ccctcacca  gcacctgcc  cccttggtc  600
gcagatttg  gccctttgc  gcagtggca  ctgccaact  catcaacat  cccctgatg  660
ggcagagag  gctgcaggt  ggcatcccg  tggctgatg  ggcaggtca  aggcttggc  720
actcggtga  tgcagccaa  cagggaatc  tccaggtgg  gatttcaag  atctgcatg  780
cgattcctg  catggccat  ccaccactg  tcatggaca  tctggagaa  aaagacttc  840
tgaagcgcc  cccctggct  ggggcaccc  tgcaggtgg  actggtggg  ttctgcctg  900
tatttgcaa  ccccctgtg  tgtgcccta  tcccccaga  gagctccat  cacataagc  960
acctggaac  agagctgag  gctcagatc  atgagcaaa  ccccagcgt  gaagtggtc  1020
actacaaca  ggggctttg  ggagggtca  cctctgtcc  ctccctcac  tccttgggc  1080
gctgcttta  tggagtcat  tcaccccta  cacttggct  tctgcctag  actgggcag  1140
ggccttggt  ggcagatgg  aattgaggg  agcaaccta  tagggtggg  gagggacct  1200
cataaggct  ttcctccct  ctctggttt  aaagatcag  gcacataac  cctcctgtg  1260
ttgagtgtc  atgcatata  atacatgat  cacatgtgt  tgtgtacat  gggtcctga  1320
agctagaag  aggcatgct  gcctagtat  ttctgacat  tggcttccc  tctcagcct  1380
atgtccacc  gcctgccag  caggctaca  gtgtgactt  cttctctaa  ctgttacac  1440
agccaagtt  tttttgatg  cacctcatc  cttctagaa  taggaggag  cccaggatc  1500
caggacaga  acttataga  actagtagg  caaagcggg  tgaatcctt  aggtttctg  1560
tacctagct  cccaagctg  ctgggctgg  agaggagaa  atgttgaga  aagggaggc  1620
ggggactta  gcatccctc  gtgccatcc  ttgtatcct  gaatagctc  atttcccct  1680
ctcctctct  ccagacaaa  gagtgcctg  gtcctgtac  gccctcgct  tctccccca  1740
caccctact  gacagcgtg  gcatcttca  gcacagcct  gggagttcc  ggtgtgctc  1800
gacatcatg  cctcaaatc  aaatcctcc  atcccaact  cctttccca  acaaaaagc  1860
acagaggca  agcaagcat  cccctttaa  agcttccac  gcaccccct  ccaagggac  1920
cagcggtag  aatggtgct  aaactccac  ggtatcaga  agggtgtaa  taggacatc  1980
tcaagggca  ctaggcccc  aatgtacaa  gttaagaca  ggaattttg  gttccattg  2040
ctttttttt  tttttttaa  ggagtttca  tattttgcc  aggctggag  gcgatggtg  2100
gatcttggc  cactgcaac  tctgcctcc  gggttcaag  gattctctt  cctcagtct  2160
ccgagtagt  gaaattaca  gtgtgtgct  ccacatctt  ctagttttg  atttttagc  2220
gagatgggg  tttcaccat  ttggccagg  tagtctcga  ctcctgacc  caggtgatc  2280
acctgcctt  gcctcccaa  gcactggga  tacaagcat  agccactgt  cccagcctg  2340
tccactgac  tttcttaga  attcagcaa  acccccacc  taacctctt  tctttcttg  2400
gggttggtc  tgtccccac  tccaccctc  caccccctg  aagaggaag  gcccgggca  2460
cagtggcta  tccaaataa  atatgggct  ggggatgga  tgggtggtg  taagttcac  2520
gagtgtagt  agatcccaa  tcccatgac  tctggcttc  gtggtgggt  gggcagggc  2580
gatgaaagg  cttcagtgg  aacctctga  agcattttc  tgttccccc  atcaaccgc  2640
cccagtgat  acatctgtg  agccagcca  tactcaata  actgcaaac  tgtctaaaa  2700
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  2735



<210> 5640
<211> 321
<212> PRT
<213> Homo sapiens
<308> Q9BWM7
<400> 5640

Met Gly Glu Leu Pro Leu Asp Ile Asn Ile Gln Glu Pro Arg Trp Asp 
  1               5                  10                  15
Gln Ser Thr Phe Leu Gly Arg Ala Arg His Phe Phe Thr Val Thr Asp 
             20                  25                  30
Pro Arg Asn Leu Leu Leu Ser Gly Ala Gln Leu Glu Ala Ser Arg Asn 
         35                  40                  45
Ile Val Gln Asn Tyr Arg Ala Gly Val Val Thr Pro Gly Ile Thr Glu 
     50                  55                  60
Asp Gln Leu Trp Arg Ala Lys Tyr Val Tyr Asp Ser Ala Phe His Pro 
 65                  70                  75                  80
Asp Thr Gly Glu Lys Val Val Leu Ile Gly Arg Met Ser Ala Gln Val 
                 85                  90                  95
Pro Met Asn Met Thr Ile Thr Gly Cys Met Leu Thr Phe Tyr Arg Lys 
             100                105                110
Thr Pro Thr Val Val Phe Trp Gln Trp Val Asn Gln Ser Phe Asn Ala 
         115                120                125
Ile Val Asn Tyr Ser Asn Arg Ser Gly Asp Thr Pro Ile Thr Val Arg 
     130                135                140
Gln Leu Gly Thr Ala Tyr Val Ser Ala Thr Thr Gly Ala Val Ala Thr 
 145                150                155                160
Ala Leu Gly Leu Lys Ser Leu Thr Lys His Leu Pro Pro Leu Val Gly 
                 165                170                175
Arg Phe Val Pro Phe Ala Ala Val Ala Ala Ala Asn Cys Ile Asn Ile 
             180                185                190
Pro Leu Met Arg Gln Arg Glu Leu Gln Val Gly Ile Pro Val Ala Asp 
         195                200                205
Glu Ala Gly Gln Arg Leu Gly Tyr Ser Val Thr Ala Ala Lys Gln Gly 
     210                215                220
Ile Phe Gln Val Val Ile Ser Arg Ile Cys Met Ala Ile Pro Ala Met 
 225                230                235                240
Ala Ile Pro Pro Leu Ile Met Asp Thr Leu Glu Lys Lys Asp Phe Leu 
                 245                250                255
Lys Arg Arg Pro Trp Leu Gly Ala Pro Leu Gln Val Gly Leu Val Gly 
             260                265                270
Phe Cys Leu Val Phe Ala Thr Pro Leu Cys Cys Ala Leu Phe Pro Gln 
         275                280                285
Lys Ser Ser Ile His Ile Ser Asn Leu Glu Pro Glu Leu Arg Ala Gln 
     290                295                300
Ile His Glu Gln Asn Pro Ser Val Glu Val Val Tyr Tyr Asn Lys Gly 
 305                310                315                320
Leu 
                 325



<210> 5641
<211> 452
<212> DNA
<213> Rattus norvegicus
<308> AA891880
<400> 5641

agacaggac  gcagtttat  gacaccatg  catgacacc  gttgtcact  gaggagggg  60
tgagtgaaa  tggtctccg  ggatatcac  ggggacccc  ttcgccttt  agctagagg  120
catggattt  gagtgcaga  ataattcta  acactggag  cattaccac  catgccatt  180
ctaaaccca  cttccattt  gtccagcta  gaaggcctg  gtccctcct  tttttgaag  240
gcagaggga  cacagggcc  tccatgtct  aggaacaag  agggctgct  gcaatggtg  300
tatatgcct  taatcccag  actcactgt  ttaggcaat  agatctctg  gttccagga  360
agccagggc  acatagaga  accatattt  aaaaacaaa  tcaaaatag  aagaaagag  420
caggaagga  ggaagaggg  gcactgggg  tg  452



<210> 5642
<211> 321
<212> PRT
<213> Rattus norvegicus
<308> Q9JHY2
<400> 5642

Met Gly Asp Leu Pro Leu Asn Ile Asn Ile Gln Glu Pro Arg Trp Asp 
  1               5                  10                  15
Gln Ser Thr Phe Leu Gly Arg Ala Arg His Phe Phe Thr Val Thr Asp 
             20                  25                  30
Pro Arg Asn Leu Leu Leu Ser Gly Lys Gln Leu Glu Ala Ser Arg Asn 
         35                  40                  45
Ile Val Gln Asn Tyr Arg Ala Gly Val Val Thr Pro Gly Leu Thr Glu 
     50                  55                  60
Asp Gln Leu Trp Arg Ala Lys Tyr Val Tyr Asp Ser Ala Phe His Pro 
 65                  70                  75                  80
Asp Thr Gly Glu Lys Val Val Leu Ile Gly Arg Met Ser Ala Gln Val 
                 85                  90                  95
Pro Met Asn Met Thr Ile Thr Gly Cys Met Leu Thr Phe Tyr Arg Lys 
             100                105                110
Thr Pro Thr Val Val Phe Trp Gln Trp Val Asn Gln Ser Phe Asn Ala 
         115                120                125
Ile Val Asn Tyr Ser Asn Arg Ser Gly Asp Ala Pro Ile Thr Val Gln 
     130                135                140
Gln Leu Gly Thr Ala Tyr Val Ser Ala Thr Thr Gly Ala Val Ala Thr 
 145                150                155                160
Ala Leu Gly Leu Lys Ser Leu Thr Lys His Leu Pro Pro Leu Val Gly 
                 165                170                175
Arg Phe Val Pro Phe Ala Ala Val Ala Ala Ala Asn Cys Ile Asn Ile 
             180                185                190
Pro Leu Met Arg Gln Arg Glu Leu Gln Val Gly Ile Pro Val Thr Asp 
         195                200                205
Glu Ala Gly Gln Arg Leu Gly His Ser Val Thr Ala Ala Lys Gln Gly 
     210                215                220
Ile Phe Gln Val Val Val Ser Arg Ile Gly Met Ala Ile Pro Ala Met 
 225                230                235                240
Ala Ile Pro Pro Val Ile Met Asn Thr Leu Glu Lys Lys Asp Phe Leu 
                 245                250                255
Lys Arg Arg Pro Trp Leu Gly Ala Pro Leu Gln Val Gly Leu Val Gly 
             260                265                270
Phe Cys Leu Val Phe Ala Thr Pro Leu Cys Cys Ala Leu Phe Pro Gln 
         275                280                285
Arg Ser Ser Ile His Val Thr Arg Leu Glu Pro Glu Leu Arg Ala Gln 
     290                295                300
Ile Gln Ala Gln Lys Pro Ser Ile Asp Val Val Tyr Tyr Asn Lys Gly 
 305                310                315                320
Leu 
                 325



<210> 5643
<211> 2735
<212> DNA
<213> Homo sapiens
<308> BC000124
<400> 5643

ggagggccc  gcggcgaca  cggaggcag  gaggaaggc  gttctgaga  cttcagaga  60
cgatggaaa  caaaatggg  gaattgcct  tagacatca  catccagga  cctcgctgg  120
accaaagta  tttcctggg  agagcccgg  actttttca  tgttactga  cctcgaaat  180
tgctgctgt  cggggcaca  ctggaagct  ctcggaaca  cgtgcagaa  tacagggcc  240
gcgtggtga  cccagggat  accgaggac  agctgtgga  ggccaagta  gtgtatgac  300
ccgccttcc  tccggacac  ggggagaag  tggtcctga  tggccgcat  tcagcccag  360
tgcccatga  catgaccat  actggctgc  tgctcacat  ctacaggaa  accccaacc  420
tggtgttct  gcagtgggt  aatcagtcc  tcaatgcca  tgttaacta  tccaaccgc  480
gtggtgaca  tcccatcac  gtgaggcag  tggggacag  ctatgtgag  gccaccact  540
gagctgtgg  cacggccct  ggactcaaa  ccctcacca  gcacctgcc  cccttggtc  600
gcagatttg  gccctttgc  gcagtggca  ctgccaact  catcaacat  cccctgatg  660
ggcagagag  gctgcaggt  ggcatcccg  tggctgatg  ggcaggtca  aggcttggc  720
actcggtga  tgcagccaa  cagggaatc  tccaggtgg  gatttcaag  atctgcatg  780
cgattcctg  catggccat  ccaccactg  tcatggaca  tctggagaa  aaagacttc  840
tgaagcgcc  cccctggct  ggggcaccc  tgcaggtgg  actggtggg  ttctgcctg  900
tatttgcaa  ccccctgtg  tgtgcccta  tcccccaga  gagctccat  cacataagc  960
acctggaac  agagctgag  gctcagatc  atgagcaaa  ccccagcgt  gaagtggtc  1020
actacaaca  ggggctttg  ggagggtca  cctctgtcc  ctccctcac  tccttgggc  1080
gctgcttta  tggagtcat  tcaccccta  cacttggct  tctgcctag  actgggcag  1140
ggccttggt  ggcagatgg  aattgaggg  agcaaccta  tagggtggg  gagggacct  1200
cataaggct  ttcctccct  ctctggttt  aaagatcag  gcacataac  cctcctgtg  1260
ttgagtgtc  atgcatata  atacatgat  cacatgtgt  tgtgtacat  gggtcctga  1320
agctagaag  aggcatgct  gcctagtat  ttctgacat  tggcttccc  tctcagcct  1380
atgtccacc  gcctgccag  caggctaca  gtgtgactt  cttctctaa  ctgttacac  1440
agccaagtt  tttttgatg  cacctcatc  cttctagaa  taggaggag  cccaggatc  1500
caggacaga  acttataga  actagtagg  caaagcggg  tgaatcctt  aggtttctg  1560
tacctagct  cccaagctg  ctgggctgg  agaggagaa  atgttgaga  aagggaggc  1620
ggggactta  gcatccctc  gtgccatcc  ttgtatcct  gaatagctc  atttcccct  1680
ctcctctct  ccagacaaa  gagtgcctg  gtcctgtac  gccctcgct  tctccccca  1740
caccctact  gacagcgtg  gcatcttca  gcacagcct  gggagttcc  ggtgtgctc  1800
gacatcatg  cctcaaatc  aaatcctcc  atcccaact  cctttccca  acaaaaagc  1860
acagaggca  agcaagcat  cccctttaa  agcttccac  gcaccccct  ccaagggac  1920
cagcggtag  aatggtgct  aaactccac  ggtatcaga  agggtgtaa  taggacatc  1980
tcaagggca  ctaggcccc  aatgtacaa  gttaagaca  ggaattttg  gttccattg  2040
ctttttttt  tttttttaa  ggagtttca  tattttgcc  aggctggag  gcgatggtg  2100
gatcttggc  cactgcaac  tctgcctcc  gggttcaag  gattctctt  cctcagtct  2160
ccgagtagt  gaaattaca  gtgtgtgct  ccacatctt  ctagttttg  atttttagc  2220
gagatgggg  tttcaccat  ttggccagg  tagtctcga  ctcctgacc  caggtgatc  2280
acctgcctt  gcctcccaa  gcactggga  tacaagcat  agccactgt  cccagcctg  2340
tccactgac  tttcttaga  attcagcaa  acccccacc  taacctctt  tctttcttg  2400
gggttggtc  tgtccccac  tccaccctc  caccccctg  aagaggaag  gcccgggca  2460
cagtggcta  tccaaataa  atatgggct  ggggatgga  tgggtggtg  taagttcac  2520
gagtgtagt  agatcccaa  tcccatgac  tctggcttc  gtggtgggt  gggcagggc  2580
gatgaaagg  cttcagtgg  aacctctga  agcattttc  tgttccccc  atcaaccgc  2640
cccagtgat  acatctgtg  agccagcca  tactcaata  actgcaaac  tgtctaaaa  2700
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  2735



<210> 5644
<211> 321
<212> PRT
<213> Homo sapiens
<308> Q9BWM7
<400> 5644

Met Gly Glu Leu Pro Leu Asp Ile Asn Ile Gln Glu Pro Arg Trp Asp 
  1               5                  10                  15
Gln Ser Thr Phe Leu Gly Arg Ala Arg His Phe Phe Thr Val Thr Asp 
             20                  25                  30
Pro Arg Asn Leu Leu Leu Ser Gly Ala Gln Leu Glu Ala Ser Arg Asn 
         35                  40                  45
Ile Val Gln Asn Tyr Arg Ala Gly Val Val Thr Pro Gly Ile Thr Glu 
     50                  55                  60
Asp Gln Leu Trp Arg Ala Lys Tyr Val Tyr Asp Ser Ala Phe His Pro 
 65                  70                  75                  80
Asp Thr Gly Glu Lys Val Val Leu Ile Gly Arg Met Ser Ala Gln Val 
                 85                  90                  95
Pro Met Asn Met Thr Ile Thr Gly Cys Met Leu Thr Phe Tyr Arg Lys 
             100                105                110
Thr Pro Thr Val Val Phe Trp Gln Trp Val Asn Gln Ser Phe Asn Ala 
         115                120                125
Ile Val Asn Tyr Ser Asn Arg Ser Gly Asp Thr Pro Ile Thr Val Arg 
     130                135                140
Gln Leu Gly Thr Ala Tyr Val Ser Ala Thr Thr Gly Ala Val Ala Thr 
 145                150                155                160
Ala Leu Gly Leu Lys Ser Leu Thr Lys His Leu Pro Pro Leu Val Gly 
                 165                170                175
Arg Phe Val Pro Phe Ala Ala Val Ala Ala Ala Asn Cys Ile Asn Ile 
             180                185                190
Pro Leu Met Arg Gln Arg Glu Leu Gln Val Gly Ile Pro Val Ala Asp 
         195                200                205
Glu Ala Gly Gln Arg Leu Gly Tyr Ser Val Thr Ala Ala Lys Gln Gly 
     210                215                220
Ile Phe Gln Val Val Ile Ser Arg Ile Cys Met Ala Ile Pro Ala Met 
 225                230                235                240
Ala Ile Pro Pro Leu Ile Met Asp Thr Leu Glu Lys Lys Asp Phe Leu 
                 245                250                255
Lys Arg Arg Pro Trp Leu Gly Ala Pro Leu Gln Val Gly Leu Val Gly 
             260                265                270
Phe Cys Leu Val Phe Ala Thr Pro Leu Cys Cys Ala Leu Phe Pro Gln 
         275                280                285
Lys Ser Ser Ile His Ile Ser Asn Leu Glu Pro Glu Leu Arg Ala Gln 
     290                295                300
Ile His Glu Gln Asn Pro Ser Val Glu Val Val Tyr Tyr Asn Lys Gly 
 305                310                315                320
Leu 
                 325



<210> 5645
<211> 497
<212> DNA
<213> Rattus norvegicus
<308> AA891891
<400> 5645

aaaaatcaa  gaatagaaa  actttacat  aaaatatgt  aattttagt  tccacattg  60
tgtccacac  gaaaattga  acatgatat  tttttgtca  actgtagca  atggccaca  120
tggtagcca  gccaattca  ctggttcac  attacgggg  tggacacac  tacctgtgc  180
tgtggatga  agaacttta  aacgcacat  tgcgggtca  tcgaacggc  ccacggtgg  240
tccttaatg  agatacagt  aatattgct  atgtgtaaa  tagtacagg  tatggacca  300
tgttcataa  tattcttta  caacaggct  cacaattta  ataatttta  ctattctga  360
gattccgat  ctcatgagc  gcagacccc  tgtgctact  tggaatatc  cccagagtc  420
acagcccca  cacagcagc  ggaggcaga  ccggataga  agcttgtcc  tggcgaggt  480
tccgtcaac  cagaatc  497



<210> 5646
<211> 383
<212> DNA
<213> Rattus norvegicus
<308> AA891911
<400> 5646

ggagttaaa  ggtgtttaa  gaggggaag  atattgaac  tatacttgt  ttattcccc  60
cccccattc  gatgaatcc  gagccatgg  aagattagc  attcaatga  actttgggt  120
atgttgagt  gctcgagaa  tcttgagga  gaggatgag  gacaacttt  taggtggtg  180
aaggatgga  gattaagac  ggaggtcac  gcatgtgta  cacaaggca  tgggactca  240
aagcaggat  gtaagcagc  tcagcatct  gtgatcaga  cttcaggct  ggctatggg  300
aatattact  ctgctttgt  ttctgctgg  atggtgatg  agtggcagt  ggggggcag  360
gctcatgaa  aacaggctg  cat  383



<210> 5647
<211> 152
<212> PRT
<213> Rattus norvegicus
<308> Q63532
<400> 5647

Met Ser Ser Gln Gln Gln Lys Gln Pro Cys Thr Val Pro Pro Gln Leu 
  1               5                  10                  15
His Gln His Glu Val Lys Gln Pro Cys Gln Pro Pro Pro Gln Glu Pro 
             20                  25                  30
Cys Ala Pro Lys Thr Lys Glu Pro Cys His Pro Ile Pro Glu Pro Cys 
         35                  40                  45
Asn Pro Lys Val Pro Glu Pro Cys Gln Pro Lys Val Pro Glu Pro Cys 
     50                  55                  60
Gln Pro Lys Val Pro Glu Pro Cys Gln Pro Lys Val Pro Glu Pro Cys 
 65                  70                  75                  80
Gln Pro Lys Val Pro Glu Pro Cys Gln Pro Lys Val Pro Glu Pro Cys 
                 85                  90                  95
Gln Pro Lys Val Pro Glu Pro Cys His Pro Lys Ala Pro Glu Pro Cys 
             100                105                110
His Pro Val Val Pro Glu Pro Cys Gln Pro Val Ala Pro Glu Pro Cys 
         115                120                125
Gln Pro Val Val Pro Glu Pro Cys Pro Pro Thr Val Thr Pro Ser Pro 
     130                135                140
Tyr Gln Gln Lys Thr Lys Gln Lys 
 145                150



<210> 5648
<211> 270
<212> DNA
<213> Homo sapiens
<308> NM_005987
<400> 5648

atgaattct  agcagcaga  gcagccttg  accccaccc  ctcagcctc  gcagcagca  60
gtgaaacaa  cttgccagc  tccacccca  gaaccatgc  tccccaaaa  caaggagcc  120
tgccaaccc  aggtgcctg  gccctgcca  cccaaagtg  ctgagccct  ccagcccaa  180
attccagag  cctgccagc  caaggtgcc  gagccctgc  cttcaacgg  cactccagc  240
ccagcccag  agaagacca  gcagaagtaa  270



<210> 5649
<211> 576
<212> DNA
<213> Rattus norvegicus
<308> AA891914
<400> 5649

aaagaacat  ccattcaac  ctggcttta  tactgggcg  gggcaacag  tccttggca  60
tggttgggc  gaaagctat  agggttgga  ggcctgggg  tcagctttc  ccaggcaga  120
cgggcacac  agcaagtgc  gcaactagg  gtgtatata  gtcaactcc  cgtagaaac  180
cagcctcgt  cagtcgttc  ttatggtca  gtagtaaca  gggtgtgcg  ttcatgggc  240
agaagccca  agctgggat  cccaccgct  ggatataac  gctgtcagt  gcagcagga  300
agatctccg  ctccagagt  aggttcatt  ccttgcagg  cccgctgaa  gctgcccac  360
aggggtccg  atcatcagt  ggtgtcatt  gaggctctg  aaacttctg  gcaaactca  420
aggtgaccc  ctctcccgc  tcctggcac  agctctgca  ctgcttctc  aaggccttc  480
tgtctacat  tggcgccac  cggaagtca  aacaggcac  catggtacc  ggtaccaca  540
tataggcca  accaccttc  ggcttagtc  gattca  576



<210> 5650
<211> 1403
<212> DNA
<213> Homo sapiens
<308> D16307
<400> 5650

gggcgctga  aggcgagcg  gagcccagc  acaggagac  caccacgcg  agcgccatg  60
ccagcaagg  tcccgagga  gagcaccca  cggtgacgc  cttccgcca  tacctgcgt  120
tccgcactg  ccagcccaa  cctgactat  gagctgctg  ggctttctt  gaggagaca  180
cccgccagc  gggcctggg  tgtcagaaa  tagaggtgg  acctggcta  gtggtgacc  240
tgttgacct  gccaggcac  aaccctaca  tctcctcca  cttgctcaa  tcccacacg  300
atgtggtgc  tgtcttcaa  gaacattgg  gtcacgacc  ctttgaggc  ttcaaggat  360
ctgagggct  catctatgc  aggggtgcc  aggacatga  gtgcgtcag  atccagtac  420
tggaagctg  gaggaggct  aaggtggag  gccaccggt  ccccagaac  atccacatg  480
cctttgtgc  tgatgagga  gttgggggt  accaaggca  ggagctgtt  gtgcagcgg  540
ctgagttcc  cgccctgag  gcaggcttt  ccctggatg  gggcatagc  aatcccact  600
atgccttca  tgtctttta  agtgagcgg  gtccctggt  ggtgcgggt  accagcact  660
ggaggccag  ccatgcctc  cgcttcatg  aggacacag  agcagagaa  ctgcacaag  720
ttgtaaact  catcctggc  ttccgggag  aggaatggc  gaggctgca  tcaaacccc  780
acctgaaag  ggggtccgt  acctccgtg  acctgacta  gctagaggg  ggcgtggcc  840
ataacgtga  acctgccac  atgagcgcc  gctttgact  ccgtgtggc  ccggatgtg  900
acttcaagg  ttttgagga  cagctgcag  gctggtgcc  ggcagctgg  gagggggtc  960
ccctagagt  tgctcagaa  tggatgcac  cccaagtga  acctactga  gactcaaac  1020
cttggtggg  agcttttag  cgggtctgc  aggatatga  cctcactct  gagcctgag  1080
tcatgcctg  tgccactga  aaccgctat  tccgcgcgg  gggggtccc  gctctaggc  1140
tctcaccca  gaaccgcac  cctgtgctg  tgcacgacc  cgatgaacg  ctgcatgag  1200
ctgtgttcc  ccgtggggt  gacatatat  cacgcctgc  gcctgccct  gccagtgtg  1260
ctgccctgc  cagtgacag  tgagccctg  aactcctaa  cctttgccc  tggggcttc  1320
atcccaacc  gtgccaagg  cctcctctt  ccccttcca  ataataaag  ctatggaca  1380
ggctgtctc  gaagtacta  cac  1403



<210> 5651
<211> 408
<212> PRT
<213> Homo sapiens
<308> Q03154
<400> 5651

Met Thr Ser Lys Gly Pro Glu Glu Glu His Pro Ser Val Thr Leu Phe 
  1               5                  10                  15
Arg Gln Tyr Leu Arg Ile Arg Thr Val Gln Pro Lys Pro Asp Tyr Gly 
             20                  25                  30
Ala Ala Val Ala Phe Phe Glu Glu Thr Ala Arg Gln Leu Gly Leu Gly 
         35                  40                  45
Cys Gln Lys Val Glu Val Ala Pro Gly Tyr Val Val Thr Val Leu Thr 
     50                  55                  60
Trp Pro Gly Thr Asn Pro Thr Leu Ser Ser Ile Leu Leu Asn Ser His 
 65                  70                  75                  80
Thr Asp Val Val Pro Val Phe Lys Glu His Trp Ser His Asp Pro Phe 
                 85                  90                  95
Glu Ala Phe Lys Asp Ser Glu Gly Tyr Ile Tyr Ala Arg Gly Ala Gln 
             100                105                110
Asp Met Lys Cys Val Ser Ile Gln Tyr Leu Glu Ala Val Arg Arg Leu 
         115                120                125
Lys Val Glu Gly His Arg Phe Pro Arg Thr Ile His Met Thr Phe Val 
     130                135                140
Pro Asp Glu Glu Val Gly Gly His Gln Gly Met Glu Leu Phe Val Gln 
 145                150                155                160
Arg Pro Glu Phe His Ala Leu Arg Ala Gly Phe Ala Leu Asp Glu Gly 
                 165                170                175
Ile Ala Asn Pro Thr Asp Ala Phe Thr Val Phe Tyr Ser Glu Arg Ser 
             180                185                190
Pro Trp Trp Val Arg Val Thr Ser Thr Gly Arg Pro Gly His Ala Ser 
         195                200                205
Arg Phe Met Glu Asp Thr Ala Ala Glu Lys Leu His Lys Val Val Asn 
     210                215                220
Ser Ile Leu Ala Phe Arg Glu Lys Glu Trp Gln Arg Leu Gln Ser Asn 
 225                230                235                240
Pro His Leu Lys Glu Gly Ser Val Thr Ser Val Asn Leu Thr Lys Leu 
                 245                250                255
Glu Gly Gly Val Ala Tyr Asn Val Ile Pro Ala Thr Met Ser Ala Ser 
             260                265                270
Phe Asp Phe Arg Val Ala Pro Asp Val Asp Phe Lys Ala Phe Glu Glu 
         275                280                285
Gln Leu Gln Ser Trp Cys Gln Ala Ala Gly Glu Gly Val Thr Leu Glu 
     290                295                300
Phe Ala Gln Lys Trp Met His Pro Gln Val Thr Pro Thr Asp Asp Ser 
 305                310                315                320
Asn Pro Trp Trp Ala Ala Phe Ser Arg Val Cys Lys Asp Met Asn Leu 
                 325                330                335
Thr Leu Glu Pro Glu Ile Met Pro Ala Ala Thr Asp Asn Arg Tyr Ile 
             340                345                350
Arg Ala Val Gly Val Pro Ala Leu Gly Phe Ser Pro Met Asn Arg Thr 
         355                360                365
Pro Val Leu Leu His Asp His Asp Glu Arg Leu His Glu Ala Val Phe 
     370                375                380
Leu Arg Gly Val Asp Ile Tyr Thr Arg Leu Leu Pro Ala Leu Ala Ser 
 385                390                395                400
Val Pro Ala Leu Pro Ser Asp Ser 
                 405



<210> 5652
<211> 550
<212> DNA
<213> Rattus norvegicus
<308> AA891943
<400> 5652

gaaagaatg  actttttag  agatatgag  gtgagactc  tgtctcgtt  ttgctggtg  60
gcttctcgg  ctctggcag  agtgtaatt  tctgcgcat  cctgacctg  agtcaggcg  120
tagaggggc  aagcatctc  gctccgggc  gcagtactg  ttgtgcgtc  ttgactcca  180
attagcgtg  tccttcagt  ttgccttcc  cctgccttc  gtttattcc  cgcatctca  240
cagaggaaa  agcagcgct  ctcctaaat  cactctaag  cactgacag  aagaatttg  300
gctgtgcta  aaagtttcc  atatgtctc  acattgttc  ccagctggt  gtgatactt  360
gggatacga  ggcatcttt  ctaatgggg  caatgtatg  atgaattat  aaccagaga  420
gggagagat  gccaagtgg  taagagtgc  tcttgcagc  gatccaagt  caggtccca  480
ggcccacat  aaaatcacc  gtaattcta  ttgcagggg  tcagatacc  tcttctggt  540
ccgtgtgtgc  550



<210> 5653
<211> 605
<212> DNA
<213> Rattus norvegicus
<308> AA891944
<400> 5653

cctataata  ctgtgatga  ttattccat  atagagatt  agatcacat  tatgttaca  60
acaatacag  ataatgtgt  tgatgacta  ataataccc  tgtacatat  tttctgtat  120
tgtacatac  accagcaaa  agaaaatct  catctgtga  ctaagacac  gaattcaca  180
cctgcttct  cagccaggc  aacagtgag  tcacagtca  tttcctgag  gctggggcc  240
ggttagagt  cctgtaacc  acacataca  ccttagaag  gctttaaga  aacacgctt  300
ctttctcac  gtcaaccta  tggagcggg  tctgtgcta  aaacgtgac  tcaagaatt  360
tttctgaat  cccatgtac  tcataagga  gggaaacaa  gcctctgat  tcattgcag  420
cctttcctg  gagtccatg  aaccacgtt  acaaaagaa  gagcaggca  aaggggagt  480
ttagcagaa  ttggttcac  cccaatccc  ctgccgtga  acttctcag  tcaacctat  540
cttacccac  ccatataaa  taaacccac  ttttacatt  aagtgatgc  ttttcataa  600
gtacc  605



<210> 5654
<211> 395
<212> PRT
<213> Rattus norvegicus
<308> AAH05419
<400> 5654

Met Glu Glu Ala Val Glu Ser Pro Glu Val Lys Glu Phe Glu Tyr Phe 
  1               5                  10                  15
Ser Asp Ala Val Phe Ile Pro Lys Asp Gly Asn Thr Leu Ser Val Gly 
             20                  25                  30
Val Ile Lys Arg Ile Glu Thr Ala Val Lys Glu Gly Glu Ile Val Lys 
         35                  40                  45
Val Val Ser Ile Val Lys Glu Ile Ile Gln Asn Val Ser Arg Asn Lys 
     50                  55                  60
Ile Lys Ile Ala Val Thr Gly Asp Ser Gly Asn Gly Met Ser Ser Phe 
 65                  70                  75                  80
Ile Asn Ala Leu Arg Leu Val Gly His Glu Glu Lys Asp Ser Ala Pro 
                 85                  90                  95
Thr Gly Val Val Arg Thr Thr Gln Lys Pro Thr Cys Tyr Phe Ser Ser 
             100                105                110
His Phe Pro Tyr Val Glu Leu Trp Asp Leu Pro Gly Leu Gly Ala Thr 
         115                120                125
Ala Gln Ser Val Glu Ser Tyr Leu Glu Glu Met Gln Ile Ser Thr Tyr 
     130                135                140
Asp Leu Ile Ile Ile Val Ala Ser Glu Gln Phe Ser Ser Asn His Val 
 145                150                155                160
Lys Leu Ala Ile Thr Met Gln Arg Met Arg Lys Arg Phe Tyr Val Val 
                 165                170                175
Trp Thr Lys Leu Asp Arg Asp Leu Ser Thr Ser Thr Phe Pro Glu Pro 
             180                185                190
Gln Leu Leu Gln Ser Ile Gln Lys Asn Ile Arg Asp Ser Leu Gln Lys 
         195                200                205
Glu Lys Val Lys Glu His Pro Met Phe Leu Val Ser Val Phe Lys Pro 
     210                215                220
Glu Ser His Asp Phe Pro Lys Leu Arg Glu Thr Leu Gln Lys Asp Leu 
 225                230                235                240
Pro Val Ile Lys Tyr His Gly Leu Val Glu Thr Leu Tyr Gln Val Cys 
                 245                250                255
Glu Lys Thr Val Asn Glu Arg Val Glu Phe Ile Lys Lys Ser Ile Asp 
             260                265                270
Glu Asp Asn Leu His Thr Asp Phe Gly Ile Ser Asp Pro Gly Asn Ala 
         275                280                285
Ile Glu Ile Arg Lys Ala Phe Gln Lys Thr Phe Gly Leu Asp Asp Ile 
     290                295                300
Ser Leu His Leu Val Ser Leu Glu Met Lys Asn Lys His Phe Asn Thr 
 305                310                315                320
Ser Met Glu Ser Gln Glu Thr Gln Arg Tyr Gln Gln Asp Asp Trp Val 
                 325                330                335
Leu Ala Arg Leu Tyr Arg Thr Gly Thr Arg Val Gly Ser Ile Gly Phe 
             340                345                350
Asp Tyr Met Lys Cys Cys Phe Ser Ser His His Ser Arg Cys Lys Gln 
         355                360                365
Gln Lys Asp Ile Leu Asp Glu Thr Ala Ala Lys Ala Lys Glu Val Leu 
     370                375                380
Leu Lys Ile Leu Arg Leu Ser Ile Pro His Pro 
 385                390                395



<210> 5655
<211> 542
<212> DNA
<213> Rattus norvegicus
<308> AA891950
<400> 5655

ccaaacggt  ccaaatact  aactgagaa  tttatttat  cgttattaa  aaggaccgg  60
ttcttctgt  ggacaacag  gcccaaaac  cctttcccc  aagtccact  ctcacagct  120
gactgaaca  ttacccaag  cggatcact  tcactgcta  tcattcaaa  cagacagaa  180
tcctgagtg  gggttctga  aagacagtt  tgcctgtct  gatggtgac  atttacatc  240
atggactct  ctttgctac  gagtttctg  aggccaagg  tcaggagga  tgccttagc  300
acaaatggt  attcctcta  tctgaagac  tgaaggtgg  cgaggctcc  gagagtgcc  360
ttgtgctta  catccatga  gccaacatg  cccgtgctt  cgttaccac  ctcagcagg  420
cctcagtgg  ttggcatag  ttggctcca  cacatgatg  gtaagaagc  ggaagaggc  480
tccaagaaa  acagcactg  gaaaagcca  caggacata  cggccgatg  aaaaggcat  540
ca  542



<210> 5656
<211> 746
<212> DNA
<213> Homo sapiens
<308> BI870835
<400> 5656

gtggaagtt  agattgtgg  tgacttttt  attggccgc  atgtcctgc  ggctttcct  60
agtgccatc  tccttggag  cctcttctt  gttttaatc  attatgttc  ggagccgat  120
tatgccaaa  cactgcact  ctactgacc  ctcttcagg  atacgaaaa  ctgttctct  180
cttcattgt  atgacattg  tgagcagga  ggcactatt  agagccttg  tttgacagc  240
ctcatgcct  aaggttaga  gagtatctg  ccatcacta  gacaaatct  tggagtcct  300
gcttccaga  acaggattg  caaattgtc  ctgtggggc  agattctta  cagcttaag  360
aggatattg  tatcttctt  gtacccgta  cttaggatt  ccaactgtt  tgaaaggga  420
atagtaaca  tgatctgct  agagtggat  ttcactcaa  tccttagta  gtggatttt  480
gggaaaaaa  cacctgggc  tctggttct  tttgataat  tataaaatt  ttcattatg  540
ggttgcagt  gtttgcaaa  gagaggcac  caaatttga  aggttattt  aatgtgata  600
tttggaaga  ttactcaga  gttggtcat  gaccactct  tgcatatat  tctgcagag  660
tctgtgaag  caatgagtg  cacttccct  tgctcttat  aaagcaatt  aatnatagc  720
taaaaaaaa  aaaaaaaaa  aagggg  746



<210> 5657
<211> 343
<212> DNA
<213> Rattus norvegicus
<308> AA891969
<400> 5657

ccatcagca  taatgaatg  gaatatttt  ttttaaatg  aacatgaag  attaaaata  60
agcctgaag  tttcaattt  gtactgtga  catcaagac  gcaattacc  ctaagaaaa  120
aattcacag  aacatgttg  actaactga  cagaaacca  agtgggtat  taagtcatt  180
catttctca  cattgtgaa  acagatgtc  tctaacaac  ccagtctac  gacagcaca  240
ttcatcata  cactacatt  aaaacacta  aaacgttta  aaagaacat  tggatttca  300
aattgccta  agaatatct  tcaatatta  aacaccatg  tgc  343



<210> 5658
<211> 141
<212> PRT
<213> Rattus norvegicus
<308> AAH05436
<400> 5658

Met Ala Gly Glu Glu Met Asn Glu Asp Tyr Pro Val Glu Ile His Glu 
  1               5                  10                  15
Ser Leu Thr Ala Leu Glu Ser Ser Leu Gly Ala Val Asp Asp Met Leu 
             20                  25                  30
Lys Thr Met Met Ala Val Ser Arg Asn Glu Leu Leu Gln Lys Leu Asp 
         35                  40                  45
Pro Leu Glu Gln Ala Lys Val Asp Leu Val Ser Ala Tyr Thr Leu Asn 
     50                  55                  60
Ser Met Phe Trp Val Tyr Leu Ala Thr Gln Gly Val Asn Pro Lys Glu 
 65                  70                  75                  80
His Pro Val Lys Gln Glu Leu Glu Arg Ile Arg Val Tyr Met Asn Arg 
                 85                  90                  95
Val Lys Glu Ile Thr Asp Lys Lys Lys Ala Ala Lys Leu Asp Arg Gly 
             100                105                110
Ala Ala Ser Arg Phe Val Lys Asn Ala Leu Trp Glu Pro Lys Ala Lys 
         115                120                125
Ser Thr Pro Lys Val Ala Asn Lys Gly Lys Ser Lys His 
     130                135                140



<210> 5659
<211> 872
<212> DNA
<213> Homo sapiens
<308> BE886831
<400> 5659

gtatttttc  aagtcagcc  taatggcag  tgaagaaat  aatgaagac  atccagtag  60
aattcacga  tatttgtca  cgtttgaga  ttccattgg  gctgtggat  agatgctga  120
gaccatgat  tctgtttct  gaaatgagt  gttgcagaa  ttggatcca  ttgaacaag  180
aaaagtgga  ttggtttct  catacacat  aaattcaat  ttttgggtt  atttggcaa  240
ccaaggagt  aatcctaag  aacatccag  aaaacagga  ttggaaaga  tcagagtat  300
tatgaacag  gtcaaggaa  taacagaca  gaaaaaggc  ggcaagctg  acagaggtg  360
agcttcaag  tttgtaaaa  atgccctct  ggaaccaaa  tcgaaaaat  catcaaaag  420
tgccaataa  ggaaaaagt  aaagttaac  ttttggttt  gatgtacac  tattcaaaa  480
gtacatctt  ccccccccc  gcaaaataa  tctgtggca  gccaaggtt  aaatgtgtt  540
cttattaat  tgtaaattc  cagtaaata  gtaagctaa  taactttcc  ctccaaaga  600
cattatctt  attgattag  cactgagga  tttaaccct  ggtgctgtc  cctttctcc  660
tcatttagc  tctcttggt  agactctta  tgctctata  agggtccgg  ttgccaggt  720
ccctttatt  ggcggtggg  aatttcagc  gcaggtctt  ggacctttg  gcgtctttc  780
aggatatgg  cttgaggat  ggctccgcg  gggacgatt  ggggcccgt  gccattttt  840
taagggggg  ggtacgcac  ttcggggaa  aa  872



<210> 5660
<211> 141
<212> PRT
<213> Homo sapiens
<308> NP_006324
<400> 5660

Met Ala Gly Glu Glu Ile Asn Glu Asp Tyr Pro Val Glu Ile His Glu 
  1               5                  10                  15
Tyr Leu Ser Ala Phe Glu Asn Ser Ile Gly Ala Val Asp Glu Met Leu 
             20                  25                  30
Lys Thr Met Met Ser Val Ser Arg Asn Glu Leu Leu Gln Lys Leu Asp 
         35                  40                  45
Pro Leu Glu Gln Ala Lys Val Asp Leu Val Ser Ala Tyr Thr Leu Asn 
     50                  55                  60
Ser Met Phe Trp Val Tyr Leu Ala Thr Gln Gly Val Asn Pro Lys Glu 
 65                  70                  75                  80
His Pro Val Lys Gln Glu Leu Glu Arg Ile Arg Val Tyr Met Asn Arg 
                 85                  90                  95
Val Lys Glu Ile Thr Asp Lys Lys Lys Ala Gly Lys Leu Asp Arg Gly 
             100                105                110
Ala Ala Ser Arg Phe Val Lys Asn Ala Leu Trp Glu Pro Lys Ser Lys 
         115                120                125
Asn Ala Ser Lys Val Ala Asn Lys Gly Lys Ser Lys Ser 
     130                135                140



<210> 5661
<211> 305
<212> DNA
<213> Rattus norvegicus
<308> AA891978
<400> 5661

cagatcctc  gaaatggag  tatagaccg  tgtgagctg  tttgtaggt  ctagaaatt  60
aacccaggt  ctctggaag  acagccagc  attgctctt  accaccaag  catctctcc  120
ggcccaaat  ctggttttt  atcatggct  tattactga  tccttccaa  ctaatctct  180
gtggcagac  tgcagcaca  cacatatca  ccaggtaag  ggtctgact  gggttttac  240
gacaagcac  ggttagatg  gtcatctta  acattacat  tctgtcctg  gagaggttc  300
agtgt  305



<210> 5662
<211> 1250
<212> DNA
<213> Homo sapiens
<308> AK000494
<400> 5662

gtttccggt  caggtgggg  aaatggcgg  gtctacagt  ttctcgact  cgtcgctga  60
gcttgctct  tcaaggcac  gcctattgt  tcctttgct  agtgtgaca  cattcagac  120
cttctacag  ggtgacagc  caacagatt  ccaaaagga  atgattgaa  tccctttgc  180
tccatggca  gagagaact  atgaatcca  agaaaccaa  agagcccgc  tgctctatg  240
gagcagaaa  aggggaatg  tggaaaact  cattcttct  agtcttttt  ctaaagaac  300
tctgcagca  atgacagaa  agcagctga  cctctatga  cgcctgatt  acgagccta  360
taatgactg  gatatttac  actgggcca  agaagctaa  ccagcccca  aaatatttg  420
aaatgaagt  atggccctg  tgagagact  tgctaaaaa  aaaaacaaa  agcagagac  480
gcgtgcccc  gatcttgag  acctctttg  aaagccacg  tgagctgtg  tccacggcc  540
ggcatgggg  ttcagtctg  ggatggtaa  tacttatga  ggacgttag  cttgcttcc  600
gcttcttag  tgcccagct  ccctacccc  gaccactgg  cctgcctca  gtgatggac  660
taaccctct  ctaggacat  catgtaaat  cacaatgtg  ctcattctc  tactttttt  720
ttcagctct  agcctcaaa  gtgatttgt  agcagcgct  gcatgcagg  tttgcctgg  780
tgctatctc  agaggcaag  ctgccacga  agggcactg  aggcgaagc  gttgtgctt  840
ctcattgcc  cagcccaag  gtactcaaa  aaaagaggc  gccggctgt  cgtgctgta  900
ggaaagcct  ccgccctcc  tgcagctcc  cgccctcag  ggcccaggg  tttgttgaa  960
tggaactcc  cacttccaa  ctggtatgg  tccttctgc  aagggaagc  aatcccagc  1020
tcctgagct  aatccttca  aggcacagc  ggcagaatg  gggccacag  caggagtgg  1080
gtgggcaca  tgcttagga  tcaacatct  catcattgg  ctttcttta  aacgtgcac  1140
ttgtaattt  aaagagaat  attaaagca  actgaaaaa  ggaaattta  aatttccca  1200
ccctcacaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  1250



<210> 5663
<211> 167
<212> PRT
<213> Homo sapiens
<308> AK000494
<400> 5663

Met Ala Val Ser Thr Val Phe Ser Thr Ser Ser Leu Met Leu Ala Leu 
  1               5                  10                  15
Ser Arg His Ser Leu Leu Ser Pro Leu Leu Ser Val Thr Ser Phe Arg 
             20                  25                  30
Arg Phe Tyr Arg Gly Asp Ser Pro Thr Asp Ser Gln Lys Asp Met Ile 
         35                  40                  45
Glu Ile Pro Leu Pro Pro Trp Gln Glu Arg Thr Asp Glu Ser Ile Glu 
     50                  55                  60
Thr Lys Arg Ala Arg Leu Leu Tyr Glu Ser Arg Lys Arg Gly Met Leu 
 65                  70                  75                  80
Glu Asn Cys Ile Leu Leu Ser Leu Phe Ala Lys Glu His Leu Gln His 
                 85                  90                  95
Met Thr Glu Lys Gln Leu Asn Leu Tyr Asp Arg Leu Ile Asn Glu Pro 
             100                105                110
Ser Asn Asp Trp Asp Ile Tyr Tyr Trp Ala Thr Glu Ala Lys Pro Ala 
         115                120                125
Pro Glu Ile Phe Glu Asn Glu Val Met Ala Leu Leu Arg Asp Phe Ala 
     130                135                140
Lys Asn Lys Asn Lys Glu Gln Arg Leu Arg Ala Pro Asp Leu Glu Tyr 
 145                150                155                160
Leu Phe Glu Lys Pro Arg Ter 
                 165



<210> 5664
<211> 363
<212> DNA
<213> Rattus norvegicus
<308> AA892012
<400> 5664

aagtacact  tcttcagac  caccagaag  gggcatcag  tctcagtac  gatgattcc  60
agccaccgt  tggttgctg  gatttgaac  caggacctc  ggaagagca  tcagtgctt  120
taaccgctg  gccatctct  cagccctct  ctgaaattc  tgaaggagt  ccactcacc  180
gaaagctgg  tccgaccct  aaggctcca  tcccggaaa  ggtctgcac  gttacaaac  240
ggccgcttt  caacacttc  ctgttctcg  ccagggcca  ttctgcaga  gccttacaa  300
aatcagcca  tcccccgat  ggtaggtat  ctttgtcca  atttttccc  gcaatctgg  360
cct  363



<210> 5665
<211> 430
<212> PRT
<213> Rattus norvegicus
<308> P00507
<400> 5665

Met Ala Leu Leu His Ser Gly Arg Val Leu Ser Gly Met Ala Ala Ala 
  1               5                  10                  15
Phe His Pro Gly Leu Ala Ala Ala Ala Ser Ala Arg Ala Ser Ser Trp 
             20                  25                  30
Trp Thr His Val Glu Met Gly Pro Pro Asp Pro Ile Leu Gly Val Thr 
         35                  40                  45
Glu Ala Phe Lys Arg Asp Thr Asn Ser Lys Lys Met Asn Leu Gly Val 
     50                  55                  60
Gly Ala Tyr Arg Asp Asp Asn Gly Lys Pro Tyr Val Leu Pro Ser Val 
 65                  70                  75                  80
Arg Lys Ala Glu Ala Gln Ile Ala Gly Lys Asn Leu Asp Lys Glu Tyr 
                 85                  90                  95
Leu Pro Ile Gly Gly Leu Ala Asp Phe Cys Lys Ala Ser Ala Glu Leu 
             100                105                110
Ala Leu Gly Glu Asn Ser Glu Val Leu Lys Ser Gly Arg Phe Val Thr 
         115                120                125
Val Gln Thr Ile Ser Gly Thr Gly Ala Leu Arg Val Gly Ala Ser Phe 
     130                135                140
Leu Gln Arg Phe Phe Lys Phe Ser Arg Asp Val Phe Leu Pro Lys Pro 
 145                150                155                160
Ser Trp Gly Asn His Thr Pro Ile Phe Arg Asp Ala Gly Met Gln Leu 
                 165                170                175
Gln Gly Tyr Arg Tyr Tyr Asp Pro Lys Thr Cys Gly Phe Asp Phe Ser 
             180                185                190
Gly Ala Leu Glu Asp Ile Ser Lys Ile Pro Glu Gln Ser Val Leu Leu 
         195                200                205
Leu His Ala Cys Ala His Asn Pro Thr Gly Val Asp Pro Arg Pro Glu 
     210                215                220
Gln Trp Lys Glu Met Ala Ala Val Val Lys Lys Lys Asn Leu Phe Ala 
 225                230                235                240
Phe Phe Asp Met Ala Tyr Gln Gly Phe Ala Ser Gly Asp Gly Asp Lys 
                 245                250                255
Asp Ala Trp Ala Val Arg His Phe Ile Glu Gln Gly Ile Asn Val Cys 
             260                265                270
Leu Cys Gln Ser Tyr Ala Lys Asn Met Gly Leu Tyr Gly Glu Arg Val 
         275                280                285
Gly Ala Phe Thr Val Val Cys Lys Asp Ala Glu Glu Ala Lys Arg Val 
     290                295                300
Glu Ser Gln Leu Lys Ile Leu Ile Arg Pro Leu Tyr Ser Asn Pro Pro 
 305                310                315                320
Leu Asn Gly Ala Arg Ile Ala Ala Thr Ile Leu Thr Ser Pro Asp Leu 
                 325                330                335
Arg Lys Gln Trp Leu Gln Glu Val Lys Gly Met Ala Asp Arg Ile Ile 
             340                345                350
Ser Met Arg Thr Gln Leu Val Ser Asn Leu Lys Lys Glu Gly Ser Ser 
         355                360                365
His Asn Trp Gln His Ile Thr Asp Gln Ile Gly Met Phe Cys Phe Thr 
     370                375                380
Gly Leu Lys Pro Glu Gln Val Glu Arg Leu Thr Lys Glu Phe Ser Val 
 385                390                395                400
Tyr Met Thr Lys Asp Gly Arg Ile Ser Val Ala Gly Val Thr Ser Gly 
                 405                410                415
Asn Val Gly Tyr Leu Ala His Ala Ile His Gln Val Thr Lys 
             420                425                430



<210> 5666
<211> 2339
<212> DNA
<213> Homo sapiens
<308> M22632
<400> 5666

ggtccacca  ggccctgct  cactccggc  gcgtcctcc  cgggatcgc  gccgccttc  60
acccgggcc  cgccgccgc  gcctctgcc  gagccagct  ctggtggac  catgtggaa  120
tgggacctc  agatcccat  ctgggagtc  ctgaagcct  taagaggga  accaatagc  180
aaaagatga  tctgggagt  ggtgcctac  gggatgata  tggaaagcc  tacgttctg  240
ctagcgtcc  caaggcaga  gcccagatt  ccgcaaaaa  tttggacaa  gaatacctg  300
ccattgggg  actggctga  ttttgcaag  catctgcag  actagccct  ggtgagaac  360
gcgaagtct  gaagagtgg  cggtttgtc  ctgtgcaga  catttctgg  actggagcc  420
taaggatcg  agccagttt  ctgcaaaga  tttttaagt  cagccgaga  gtctttctg  480
ccaaaccaa  ctggggaaa  cacacaccc  tcttcaggg  tgctggcat  cagctacaa  540
gttatcggt  ttatgaccc  aagacttgc  gttttgact  cacaggcgc  gtggaggat  600
tttcaaaaa  accagagca  agtgttctt  ttctgcatg  ctgcgccca  aatcccacg  660
gagtggacc  gcgtccgga  cagtggaag  aaatagcaa  agtggtgaa  aaaaggaat  720
tctttgcgt  ctttgacat  gcctaccaa  gctttgcca  tggtgatgg  gataaggat  780
cctgggctg  gcgccactt  atcgaacag  gcattaatg  ttgcctctg  caatcatat  840
ccaagaaca  gggcttata  ggtgagcgt  taggagcct  cactatggt  tgcaaagat  900
cggatgaag  caaaagggt  gagtcacag  tgaagatct  gatccgtcc  atgtattcc  960
accctcccc  caatggggc  cggattgct  ctgccattc  gaacacccc  gatttgcga  1020
aacaatggc  gcaagaagt  aaaggcatg  ctgaccgca  cattggcat  cggactcaa  1080
tggtctcca  cctcaagaa  gagggttcc  cccacaatt  gcaacacat  accgaccaa  1140
ttggcatgt  ctgtttcac  gggctaaag  ctgaacagg  ggagcggct  atcaaggag  1200
tctccatct  catgacaaa  gatggccgc  tctctgtgg  aggggtcac  tccagcaac  1260
tgggctacc  tgcccatgc  attcaccag  tcaccaagt  atgtccctg  gtcgaggaa  1320
cagagacaa  ctttctgtc  tcagcctct  ctattgaga  cttcacaca  acaatgaga  1380
agggtggat  gtggtgagt  gatcatttc  ttcagccac  gtgtgtaac  ctcagcatt  1440
gaatgtttc  cagaaaaga  catgtagtg  cacagggca  aggcatcca  ggctggcgt  1500
tggaatatt  aaccaaact  tccccggtc  ttttttctc  aacttttct  aaagagttt  1560
catgtgcaa  aaagtcatc  caccaaaaa  cctgtcaat  atgccattg  aatatttca  1620
aagctttaa  tgaagtgtc  ggttcctcg  gagaaacaa  cacacctta  aggctttga  1680
agaaggcca  ctagttctg  catgagtag  cggcctcgt  tctgtcctc  catcttgga  1740
caaccttat  aacaggccg  actgcagaa  tgatgtttt  tgaaaacca  gagctgctg  1800
cactccagc  agggaaata  tgcagtttc  tgtcttatt  aagaaaaag  gaaggctct  1860
ttttctccc  tgtcattgc  gttcttttc  ttacacgca  aacattttt  actattgca  1920
tttcatccc  ttctactgc  tgattgacc  tcaactcca  cctatcgag  ttatttaag  1980
atgaagaac  taatttttc  gctgatgcc  taccctcac  cttttcagc  aagaatagt  2040
gagagtagg  aactgtact  tatctcggc  tcctcttga  tgatagtgc  agtttctcc  2100
gttgggatg  tgtctctgc  cggttggac  tcctccctt  gttgaatgt  gtgtgcagc  2160
tctcatctc  cactgtgag  ccagcggcg  agggtggta  caggaaaga  gatattcta  2220
gcttgcgtg  tgctagctg  gttcaggct  cacccactg  aaagaacca  catctgctc  2280
aaccatgta  acttattgc  gcctggttt  ctctgttac  ataaaatta  tgtagaccc  2339



<210> 5667
<211> 430
<212> PRT
<213> Homo sapiens
<308> P00505
<400> 5667

Met Ala Leu Leu His Ser Gly Arg Val Leu Pro Gly Ile Ala Ala Ala 
  1               5                  10                  15
Phe His Pro Gly Leu Ala Ala Ala Ala Ser Ala Arg Ala Ser Ser Trp 
             20                  25                  30
Trp Thr His Val Glu Met Gly Pro Pro Asp Pro Ile Leu Gly Val Thr 
         35                  40                  45
Glu Ala Phe Lys Arg Asp Thr Asn Ser Lys Lys Met Asn Leu Gly Val 
     50                  55                  60
Gly Ala Tyr Arg Asp Asp Asn Gly Lys Pro Tyr Val Leu Pro Ser Val 
 65                  70                  75                  80
Arg Lys Ala Glu Ala Gln Ile Ala Ala Lys Asn Leu Asp Lys Glu Tyr 
                 85                  90                  95
Leu Pro Ile Gly Gly Leu Ala Glu Phe Cys Lys Ala Ser Ala Glu Leu 
             100                105                110
Ala Leu Gly Glu Asn Ser Glu Val Leu Lys Ser Gly Arg Phe Val Thr 
         115                120                125
Val Gln Thr Ile Ser Gly Thr Gly Ala Leu Arg Ile Gly Ala Ser Phe 
     130                135                140
Leu Gln Arg Phe Phe Lys Phe Ser Arg Asp Val Phe Leu Pro Lys Pro 
 145                150                155                160
Thr Trp Gly Asn His Thr Pro Ile Phe Arg Asp Ala Gly Met Gln Leu 
                 165                170                175
Gln Gly Tyr Arg Tyr Tyr Asp Pro Lys Thr Cys Gly Phe Asp Phe Thr 
             180                185                190
Gly Ala Val Glu Asp Ile Ser Lys Ile Pro Glu Gln Ser Val Leu Leu 
         195                200                205
Leu His Ala Cys Ala His Asn Pro Thr Gly Val Asp Pro Arg Pro Glu 
     210                215                220
Gln Trp Lys Glu Ile Ala Thr Val Val Lys Lys Arg Asn Leu Phe Ala 
 225                230                235                240
Phe Phe Asp Met Ala Tyr Gln Gly Phe Ala Ser Gly Asp Gly Asp Lys 
                 245                250                255
Asp Ala Trp Ala Val Arg His Phe Ile Glu Gln Gly Ile Asn Val Cys 
             260                265                270
Leu Cys Gln Ser Tyr Ala Lys Asn Met Gly Leu Tyr Gly Glu Arg Val 
         275                280                285
Gly Ala Phe Thr Met Val Cys Lys Asp Ala Asp Glu Ala Lys Arg Val 
     290                295                300
Glu Ser Gln Leu Lys Ile Leu Ile Arg Pro Met Tyr Ser Asn Pro Pro 
 305                310                315                320
Leu Asn Gly Ala Arg Ile Ala Ala Ala Ile Leu Asn Thr Pro Asp Leu 
                 325                330                335
Arg Lys Gln Trp Leu Gln Glu Val Lys Gly Met Ala Asp Arg Ile Ile 
             340                345                350
Gly Met Arg Thr Gln Leu Val Ser Asn Leu Lys Lys Glu Gly Ser Thr 
         355                360                365
His Asn Trp Gln His Ile Thr Asp Gln Ile Gly Met Phe Cys Phe Thr 
     370                375                380
Gly Leu Lys Pro Glu Gln Val Glu Arg Leu Ile Lys Glu Phe Ser Ile 
 385                390                395                400
Tyr Met Thr Lys Asp Gly Arg Ile Ser Val Ala Gly Val Thr Ser Ser 
                 405                410                415
Asn Val Gly Tyr Leu Ala His Ala Ile His Gln Val Thr Lys 
             420                425                430



<210> 5668
<211> 363
<212> DNA
<213> Rattus norvegicus
<308> AA892012
<400> 5668

aagtacact  tcttcagac  caccagaag  gggcatcag  tctcagtac  gatgattcc  60
agccaccgt  tggttgctg  gatttgaac  caggacctc  ggaagagca  tcagtgctt  120
taaccgctg  gccatctct  cagccctct  ctgaaattc  tgaaggagt  ccactcacc  180
gaaagctgg  tccgaccct  aaggctcca  tcccggaaa  ggtctgcac  gttacaaac  240
ggccgcttt  caacacttc  ctgttctcg  ccagggcca  ttctgcaga  gccttacaa  300
aatcagcca  tcccccgat  ggtaggtat  ctttgtcca  atttttccc  gcaatctgg  360
cct  363



<210> 5669
<211> 430
<212> PRT
<213> Rattus norvegicus
<308> P00507
<400> 5669

Met Ala Leu Leu His Ser Gly Arg Val Leu Ser Gly Met Ala Ala Ala 
  1               5                  10                  15
Phe His Pro Gly Leu Ala Ala Ala Ala Ser Ala Arg Ala Ser Ser Trp 
             20                  25                  30
Trp Thr His Val Glu Met Gly Pro Pro Asp Pro Ile Leu Gly Val Thr 
         35                  40                  45
Glu Ala Phe Lys Arg Asp Thr Asn Ser Lys Lys Met Asn Leu Gly Val 
     50                  55                  60
Gly Ala Tyr Arg Asp Asp Asn Gly Lys Pro Tyr Val Leu Pro Ser Val 
 65                  70                  75                  80
Arg Lys Ala Glu Ala Gln Ile Ala Gly Lys Asn Leu Asp Lys Glu Tyr 
                 85                  90                  95
Leu Pro Ile Gly Gly Leu Ala Asp Phe Cys Lys Ala Ser Ala Glu Leu 
             100                105                110
Ala Leu Gly Glu Asn Ser Glu Val Leu Lys Ser Gly Arg Phe Val Thr 
         115                120                125
Val Gln Thr Ile Ser Gly Thr Gly Ala Leu Arg Val Gly Ala Ser Phe 
     130                135                140
Leu Gln Arg Phe Phe Lys Phe Ser Arg Asp Val Phe Leu Pro Lys Pro 
 145                150                155                160
Ser Trp Gly Asn His Thr Pro Ile Phe Arg Asp Ala Gly Met Gln Leu 
                 165                170                175
Gln Gly Tyr Arg Tyr Tyr Asp Pro Lys Thr Cys Gly Phe Asp Phe Ser 
             180                185                190
Gly Ala Leu Glu Asp Ile Ser Lys Ile Pro Glu Gln Ser Val Leu Leu 
         195                200                205
Leu His Ala Cys Ala His Asn Pro Thr Gly Val Asp Pro Arg Pro Glu 
     210                215                220
Gln Trp Lys Glu Met Ala Ala Val Val Lys Lys Lys Asn Leu Phe Ala 
 225                230                235                240
Phe Phe Asp Met Ala Tyr Gln Gly Phe Ala Ser Gly Asp Gly Asp Lys 
                 245                250                255
Asp Ala Trp Ala Val Arg His Phe Ile Glu Gln Gly Ile Asn Val Cys 
             260                265                270
Leu Cys Gln Ser Tyr Ala Lys Asn Met Gly Leu Tyr Gly Glu Arg Val 
         275                280                285
Gly Ala Phe Thr Val Val Cys Lys Asp Ala Glu Glu Ala Lys Arg Val 
     290                295                300
Glu Ser Gln Leu Lys Ile Leu Ile Arg Pro Leu Tyr Ser Asn Pro Pro 
 305                310                315                320
Leu Asn Gly Ala Arg Ile Ala Ala Thr Ile Leu Thr Ser Pro Asp Leu 
                 325                330                335
Arg Lys Gln Trp Leu Gln Glu Val Lys Gly Met Ala Asp Arg Ile Ile 
             340                345                350
Ser Met Arg Thr Gln Leu Val Ser Asn Leu Lys Lys Glu Gly Ser Ser 
         355                360                365
His Asn Trp Gln His Ile Thr Asp Gln Ile Gly Met Phe Cys Phe Thr 
     370                375                380
Gly Leu Lys Pro Glu Gln Val Glu Arg Leu Thr Lys Glu Phe Ser Val 
 385                390                395                400
Tyr Met Thr Lys Asp Gly Arg Ile Ser Val Ala Gly Val Thr Ser Gly 
                 405                410                415
Asn Val Gly Tyr Leu Ala His Ala Ile His Gln Val Thr Lys 
             420                425                430



<210> 5670
<211> 2339
<212> DNA
<213> Homo sapiens
<308> M22632
<400> 5670

ggtccacca  ggccctgct  cactccggc  gcgtcctcc  cgggatcgc  gccgccttc  60
acccgggcc  cgccgccgc  gcctctgcc  gagccagct  ctggtggac  catgtggaa  120
tgggacctc  agatcccat  ctgggagtc  ctgaagcct  taagaggga  accaatagc  180
aaaagatga  tctgggagt  ggtgcctac  gggatgata  tggaaagcc  tacgttctg  240
ctagcgtcc  caaggcaga  gcccagatt  ccgcaaaaa  tttggacaa  gaatacctg  300
ccattgggg  actggctga  ttttgcaag  catctgcag  actagccct  ggtgagaac  360
gcgaagtct  gaagagtgg  cggtttgtc  ctgtgcaga  catttctgg  actggagcc  420
taaggatcg  agccagttt  ctgcaaaga  tttttaagt  cagccgaga  gtctttctg  480
ccaaaccaa  ctggggaaa  cacacaccc  tcttcaggg  tgctggcat  cagctacaa  540
gttatcggt  ttatgaccc  aagacttgc  gttttgact  cacaggcgc  gtggaggat  600
tttcaaaaa  accagagca  agtgttctt  ttctgcatg  ctgcgccca  aatcccacg  660
gagtggacc  gcgtccgga  cagtggaag  aaatagcaa  agtggtgaa  aaaaggaat  720
tctttgcgt  ctttgacat  gcctaccaa  gctttgcca  tggtgatgg  gataaggat  780
cctgggctg  gcgccactt  atcgaacag  gcattaatg  ttgcctctg  caatcatat  840
ccaagaaca  gggcttata  ggtgagcgt  taggagcct  cactatggt  tgcaaagat  900
cggatgaag  caaaagggt  gagtcacag  tgaagatct  gatccgtcc  atgtattcc  960
accctcccc  caatggggc  cggattgct  ctgccattc  gaacacccc  gatttgcga  1020
aacaatggc  gcaagaagt  aaaggcatg  ctgaccgca  cattggcat  cggactcaa  1080
tggtctcca  cctcaagaa  gagggttcc  cccacaatt  gcaacacat  accgaccaa  1140
ttggcatgt  ctgtttcac  gggctaaag  ctgaacagg  ggagcggct  atcaaggag  1200
tctccatct  catgacaaa  gatggccgc  tctctgtgg  aggggtcac  tccagcaac  1260
tgggctacc  tgcccatgc  attcaccag  tcaccaagt  atgtccctg  gtcgaggaa  1320
cagagacaa  ctttctgtc  tcagcctct  ctattgaga  cttcacaca  acaatgaga  1380
agggtggat  gtggtgagt  gatcatttc  ttcagccac  gtgtgtaac  ctcagcatt  1440
gaatgtttc  cagaaaaga  catgtagtg  cacagggca  aggcatcca  ggctggcgt  1500
tggaatatt  aaccaaact  tccccggtc  ttttttctc  aacttttct  aaagagttt  1560
catgtgcaa  aaagtcatc  caccaaaaa  cctgtcaat  atgccattg  aatatttca  1620
aagctttaa  tgaagtgtc  ggttcctcg  gagaaacaa  cacacctta  aggctttga  1680
agaaggcca  ctagttctg  catgagtag  cggcctcgt  tctgtcctc  catcttgga  1740
caaccttat  aacaggccg  actgcagaa  tgatgtttt  tgaaaacca  gagctgctg  1800
cactccagc  agggaaata  tgcagtttc  tgtcttatt  aagaaaaag  gaaggctct  1860
ttttctccc  tgtcattgc  gttcttttc  ttacacgca  aacattttt  actattgca  1920
tttcatccc  ttctactgc  tgattgacc  tcaactcca  cctatcgag  ttatttaag  1980
atgaagaac  taatttttc  gctgatgcc  taccctcac  cttttcagc  aagaatagt  2040
gagagtagg  aactgtact  tatctcggc  tcctcttga  tgatagtgc  agtttctcc  2100
gttgggatg  tgtctctgc  cggttggac  tcctccctt  gttgaatgt  gtgtgcagc  2160
tctcatctc  cactgtgag  ccagcggcg  agggtggta  caggaaaga  gatattcta  2220
gcttgcgtg  tgctagctg  gttcaggct  cacccactg  aaagaacca  catctgctc  2280
aaccatgta  acttattgc  gcctggttt  ctctgttac  ataaaatta  tgtagaccc  2339



<210> 5671
<211> 430
<212> PRT
<213> Homo sapiens
<308> P00505
<400> 5671

Met Ala Leu Leu His Ser Gly Arg Val Leu Pro Gly Ile Ala Ala Ala 
  1               5                  10                  15
Phe His Pro Gly Leu Ala Ala Ala Ala Ser Ala Arg Ala Ser Ser Trp 
             20                  25                  30
Trp Thr His Val Glu Met Gly Pro Pro Asp Pro Ile Leu Gly Val Thr 
         35                  40                  45
Glu Ala Phe Lys Arg Asp Thr Asn Ser Lys Lys Met Asn Leu Gly Val 
     50                  55                  60
Gly Ala Tyr Arg Asp Asp Asn Gly Lys Pro Tyr Val Leu Pro Ser Val 
 65                  70                  75                  80
Arg Lys Ala Glu Ala Gln Ile Ala Ala Lys Asn Leu Asp Lys Glu Tyr 
                 85                  90                  95
Leu Pro Ile Gly Gly Leu Ala Glu Phe Cys Lys Ala Ser Ala Glu Leu 
             100                105                110
Ala Leu Gly Glu Asn Ser Glu Val Leu Lys Ser Gly Arg Phe Val Thr 
         115                120                125
Val Gln Thr Ile Ser Gly Thr Gly Ala Leu Arg Ile Gly Ala Ser Phe 
     130                135                140
Leu Gln Arg Phe Phe Lys Phe Ser Arg Asp Val Phe Leu Pro Lys Pro 
 145                150                155                160
Thr Trp Gly Asn His Thr Pro Ile Phe Arg Asp Ala Gly Met Gln Leu 
                 165                170                175
Gln Gly Tyr Arg Tyr Tyr Asp Pro Lys Thr Cys Gly Phe Asp Phe Thr 
             180                185                190
Gly Ala Val Glu Asp Ile Ser Lys Ile Pro Glu Gln Ser Val Leu Leu 
         195                200                205
Leu His Ala Cys Ala His Asn Pro Thr Gly Val Asp Pro Arg Pro Glu 
     210                215                220
Gln Trp Lys Glu Ile Ala Thr Val Val Lys Lys Arg Asn Leu Phe Ala 
 225                230                235                240
Phe Phe Asp Met Ala Tyr Gln Gly Phe Ala Ser Gly Asp Gly Asp Lys 
                 245                250                255
Asp Ala Trp Ala Val Arg His Phe Ile Glu Gln Gly Ile Asn Val Cys 
             260                265                270
Leu Cys Gln Ser Tyr Ala Lys Asn Met Gly Leu Tyr Gly Glu Arg Val 
         275                280                285
Gly Ala Phe Thr Met Val Cys Lys Asp Ala Asp Glu Ala Lys Arg Val 
     290                295                300
Glu Ser Gln Leu Lys Ile Leu Ile Arg Pro Met Tyr Ser Asn Pro Pro 
 305                310                315                320
Leu Asn Gly Ala Arg Ile Ala Ala Ala Ile Leu Asn Thr Pro Asp Leu 
                 325                330                335
Arg Lys Gln Trp Leu Gln Glu Val Lys Gly Met Ala Asp Arg Ile Ile 
             340                345                350
Gly Met Arg Thr Gln Leu Val Ser Asn Leu Lys Lys Glu Gly Ser Thr 
         355                360                365
His Asn Trp Gln His Ile Thr Asp Gln Ile Gly Met Phe Cys Phe Thr 
     370                375                380
Gly Leu Lys Pro Glu Gln Val Glu Arg Leu Ile Lys Glu Phe Ser Ile 
 385                390                395                400
Tyr Met Thr Lys Asp Gly Arg Ile Ser Val Ala Gly Val Thr Ser Ser 
                 405                410                415
Asn Val Gly Tyr Leu Ala His Ala Ile His Gln Val Thr Lys 
             420                425                430



<210> 5672
<211> 531
<212> DNA
<213> Rattus norvegicus
<308> AA892049
<400> 5672

gaagtagcg  tctctaggt  acacaggat  agcggcgca  acagagctt  tgattattc  60
caaaatgta  tgcaaccac  gcaaacaaa  aacaataac  aagcccaaa  cacacaaga  120
caaatttaa  ctgcttgca  ttttatgtt  ctttttatt  tgggtatgt  tgtgtctca  180
gctccagtg  cagtgtctg  ctagcatga  gttctgagc  tgacattca  aactacata  240
gccaggaat  gtgggtggc  cacagtggt  atcctggca  tctgatgag  caggagggt  300
aagatttta  ggttgtggc  tgtagtagt  aagaacttg  tctttcaca  gacccaagt  360
aaatcccca  cacctttgg  gaggaagga  gatctcaca  ctgcctgca  ctctagttc  420
aggagatcc  gcggctcta  caaccaagg  atcttgcac  accaccatt  gcctccttc  480
caaaacatg  agtggccct  aaaaggacc  ttaaggatg  tccggatgt  t  531



<210> 5673
<211> 404
<212> DNA
<213> Rattus norvegicus
<308> AA892094
<400> 5673

actgtaaga  tataaacgt  ttaagagga  ctttgttat  atttataca  attcacaaa  60
agtacaatt  attgataaa  gtctctggg  ttctccatg  tctctcatg  tgctgtgga  120
gactctaaa  aaataaaca  acaaaatat  caacaaaaa  atacatcct  ctcaaaagc  180
atttgtttt  aagccacag  cccaacccc  caccaaaat  aagtcatct  ttcctccat  240
tagaaacaa  agtttttca  actcacacg  tcctcccat  tcatgaaca  aacacagat  300
agacatgaa  ttcagtctc  tccctttca  atagcctcg  gctctctgc  gactctgag  360
tcctagaca  ggctggaag  ctcactgta  ccttctggt  ggaa  404



<210> 5674
<211> 404
<212> DNA
<213> Rattus norvegicus
<308> AA892094
<400> 5674

actgtaaga  tataaacgt  ttaagagga  ctttgttat  atttataca  attcacaaa  60
agtacaatt  attgataaa  gtctctggg  ttctccatg  tctctcatg  tgctgtgga  120
gactctaaa  aaataaaca  acaaaatat  caacaaaaa  atacatcct  ctcaaaagc  180
atttgtttt  aagccacag  cccaacccc  caccaaaat  aagtcatct  ttcctccat  240
tagaaacaa  agtttttca  actcacacg  tcctcccat  tcatgaaca  aacacagat  300
agacatgaa  ttcagtctc  tccctttca  atagcctcg  gctctctgc  gactctgag  360
tcctagaca  ggctggaag  ctcactgta  ccttctggt  ggaa  404



<210> 5675
<211> 476
<212> DNA
<213> Rattus norvegicus
<308> AA892120
<400> 5675

ccaagttca  cagtcgttt  ttgtgctcc  agagcttcc  atcccggtt  ttgcagcct  60
ccttccaaa  gcaagcccg  gacagagcc  ggttcactt  gcctgggtc  tgtaattct  120
ggcaggtct  tagtcctta  gggagaacc  gttggggtg  agttcaggc  gcaggtctg  180
gcatacatc  gcccatagt  caagtttgc  gtgctctct  cacaagatg  agcgtctac  240
gacagctct  aggcactag  gatctacaa  agttctggg  tcgagttac  aaccatcgg  300
accatgatg  ggtcctggg  gacccctca  gcccctgct  agaaatgca  tgagctctt  360
cacctgggc  agaaacagc  agtagtgct  gagtgtatg  tgcagcgtt  gcaagccag  420
aactgtagc  actgcaaag  gtgacaagg  ggttctggg  acaattttt  tttgag  476



<210> 5676
<211> 528
<212> DNA
<213> Rattus norvegicus
<308> AA892127
<400> 5676

aatgtaaac  aggaattta  tcaactgat  accagacaa  gaaatgcta  ggagtacaa  60
aggcattta  aacttaaat  atttatcac  gacttcagt  aagtcaaat  cttcaactg  120
atcagagtt  aatatcgga  acaaaaagg  taattacaa  atatctggg  caaggaatc  180
tctccgctg  aaacacttg  gaagcttgt  tcctggcag  tctctcctc  ggggacagg  240
taccctcca  tgctactat  tggtactgc  tatgcttca  atttcccac  catttccgg  300
gctgcctga  actaccagc  tccatgtct  gctttaaca  cttctgcat  tctcgagaa  360
gacatccag  atcaaatat  agcaaacat  atgttcgtt  ttttctctc  tcaatccca  420
caactgttc  actgtgacc  tgatgctgg  gatagacag  aggtttgga  gtacacacg  480
cctttggcg  cccttccgt  tctgaggaa  tatagttca  tatccact  528



<210> 5677
<211> 442
<212> DNA
<213> Rattus norvegicus
<308> AA892137
<400> 5677

aatgcacga  cttaaaacc  taaaaagac  tcctttttt  tctttactt  ataagtcat  60
acaatagat  agggaccac  gtagcttta  aaatcatga  gatgcatgt  cagtcacaa  120
cccagcttt  gtaacacgt  ttaagagga  agtacacct  gtaacacgt  tacatttac  180
cacacattt  ctttgacta  cctctgggg  tgatgaaag  tcaatcata  acctcaaat  240
ttgcttttg  taactagat  tgtataaac  ataaagaag  atttacaaa  tttttttca  300
tagcctttt  gttcaaatc  aagatatct  gtggatgta  tttttttcc  cattcttta  360
ctagattct  gtattggca  tcataattt  ctctttcaa  tcatcttca  aagcttaac  420
cgagaaagt  cttctccaa  gt  442



<210> 5678
<211> 1676
<212> DNA
<213> Homo sapiens
<308> AL109701
<400> 5678

cctagaggt  gagcggttt  cacaatgtc  gaaatggct  agttgtccg  gctgtatga  60
gagagcagt  acctgcaga  ggatgtgat  cctggcgag  gtgaccttc  gcagatgga  120
gtaggcagc  ggagccggg  gctatccct  cgtccctcc  gcagcgggg  ccaacagct  180
gaggaggaa  gcccaatgg  ggaggagga  gcccagcca  tggcggcgc  agaggggaa  240
cggagcctt  ctaacgggc  caacgctgg  gagcagcca  gccaggtgg  gggcgcaga  300
ttcgagagc  aggacgagg  cgaggaatt  gatgactgg  aggacgact  cgactatcc  360
gaagaggag  agctcagtg  tgccggcta  agagtatca  ccgctcttg  agaagccga  420
aagatgttt  tgagaacaa  agaaccagc  ctggatggc  ggtttcaga  gcattatga  480
aagaccccg  ttgatcagt  agcttttat  gaagagctt  tttcactga  ggttgtcaa  540
cgtctgacc  aagaactcg  ctgtgatga  attattgat  gagagtagt  agatgctgt  600
aaaagagga  gaaactact  gaggaggga  ccaactttc  gctatcttt  gggttcatt  660
caaatagtt  tgtgccatt  aaaaacttg  ccttcaaaa  aatttgttt  tcagaatag  720
acacaatag  acagtgact  cacagttgt  aaaaaggaa  agaatcatt  aagaaaaag  780
aaaaagatt  taagaccgt  gaaatcaat  atcaagaac  tcctaaaac  cctatggct  840
tgactttgt  attgatcca  attattttc  ttgcattgg  gaaaatatc  ttcatattt  900
tttgctgta  agatggttt  gcaagaata  gtcatgacc  agacaaact  ccaatacaa  960
agcccactg  tactaatta  ataatgaga  aaaaatgta  ccaactagg  cacatatct  1020
ttgagttat  tggactgaa  gcttaagaa  acttggaaa  ttctatttt  tgatctagt  1080
aagccacag  tatcaaagg  tacattttc  gtgtaagat  aatggatga  taaactcaa  1140
tatgtatca  gtgtgcttt  tatcttaag  tgtgtttcc  agagcatct  aaattttgt  1200
tgtacatgt  tcttgatca  ttataaagc  actgtgatc  ataaatcaa  aaaatccat  1260
gtcataacc  tttttaaaa  tcaaaaatt  agacatcct  aattaaaaa  tttcaaatc  1320
agacactaa  tgtgtgtga  tgtacaaag  aaacaaacc  ttgcttatg  tgttatata  1380
tagagaaat  ttgttttgc  tgctgtttt  acttgacag  tgaaggact  tagttgaac  1440
tcatattgt  agaactgtt  ataaaagtt  tcaagtaaa  agcgctata  ctaaaaaga  1500
tttatgaac  gttattcta  caactttta  aggttttaa  cctgcccag  aattacctt  1560
gtatctgaa  tttccctct  tctcctcct  taattaagc  tgttatttg  catgcacca  1620
cattggaga  aataaaatt  cttgttctg  gtaaaaaaa  aaaaaaaaa  aaaaaa  1676



<210> 5679
<211> 188
<212> PRT
<213> Homo sapiens
<308> AL109701
<400> 5679

Met Ser Glu Met Ala Glu Leu Ser Glu Leu Tyr Glu Glu Ser Ser Asp 
  1               5                  10                  15
Leu Gln Met Asp Val Met Pro Gly Glu Gly Asp Leu Pro Gln Met Glu 
             20                  25                  30
Val Gly Ser Gly Ser Arg Glu Leu Ser Leu Arg Pro Ser Arg Ser Gly 
         35                  40                  45
Ala Gln Gln Leu Glu Glu Glu Gly Pro Met Glu Glu Glu Glu Ala Gln 
     50                  55                  60
Pro Met Ala Ala Pro Glu Gly Lys Arg Ser Leu Ala Asn Gly Pro Asn 
 65                  70                  75                  80
Ala Gly Glu Gln Pro Gly Gln Val Ala Gly Ala Asp Phe Glu Ser Glu 
                 85                  90                  95
Asp Glu Gly Glu Glu Phe Asp Asp Trp Glu Asp Asp Tyr Asp Tyr Pro 
             100                105                110
Glu Glu Glu Gln Leu Ser Gly Ala Gly Tyr Arg Val Ser Ala Ala Leu 
         115                120                125
Glu Glu Ala Asp Lys Met Phe Leu Arg Thr Arg Glu Pro Ala Leu Asp 
     130                135                140
Gly Gly Phe Gln Met His Tyr Glu Lys Thr Pro Phe Asp Gln Leu Ala 
 145                150                155                160
Phe Ile Glu Glu Leu Phe Ser Leu Met Val Val Asn Arg Leu Thr Glu 
                 165                170                175
Glu Leu Gly Cys Asp Glu Ile Ile Asp Arg Glu Ter 
             180                185



<210> 5680
<211> 486
<212> DNA
<213> Rattus norvegicus
<308> AA892149
<400> 5680

gaagacatt  ccagtaagt  tttgaagcc  tggcttagt  cccatccgt  ctagtcacc  60
gagttctcg  gcacaatcc  attgcctgc  atggtattt  tcaaaacta  aaatgctag  120
acactgcct  tgccaacac  gcacccagt  gtccatatc  aatactcca  cagctggaa  180
accaaaggc  aatgctgca  acagagtcc  aacaacatt  ttcacagaa  aaaacagtg  240
gacaaattt  tacaacatg  cacctgcca  ttcctcaat  ttattactg  aattatctc  300
aggatagta  aattaggct  cacaacctg  ggttgctcg  ctttttaaa  aaaaaccta  360
gttctaaaa  gtataaaca  gtatacaca  agacttgtt  ataaacttt  gatatttga  420
atctgtatg  catgatgac  acatggaga  aggacacat  gcacgaagt  catagtggg  480
atgcgc  486



<210> 5681
<211> 386
<212> DNA
<213> Rattus norvegicus
<308> AA892154
<400> 5681

gaggtataa  aatctgtat  tatattaca  tgacataat  acacagcac  gccccatct  60
ttagacagg  gggatgggg  cccattcca  tctgcagct  aggtctcat  actcaccca  120
tgcactggc  ccaggcccc  tgtgtagcc  cagactctg  cacggaacc  gccctagaa  180
agcaagctc  accacctgc  ggttagaaa  acagaggca  acctagggc  catatggag  240
caaaacctc  gtgtcctct  ctgctagac  agctgggtc  gcagcagga  ggtgggtct  300
gtacatctg  accacctcc  acgaaagag  cccaagcct  agcctggag  tgcagactc  360
gttatggag  acacgtggc  cacatg  386



<210> 5682
<211> 228
<212> PRT
<213> Rattus norvegicus
<308> NP_037292
<400> 5682

Met Glu Arg Val Lys Met Ile Asn Val Gln Pro Met Leu Glu Ala Ala 
  1               5                  10                  15
Glu Phe Leu Glu Arg Arg Glu Arg Glu Cys Glu His Gly Tyr Ala Ser 
             20                  25                  30
Ser Phe Pro Ser Met Pro Ser Pro Arg Leu Gln His Ser Lys Pro Pro 
         35                  40                  45
Arg Arg Leu Ser Arg Ala Gln Lys His Ser Ser Gly Ser Ser Asn Thr 
     50                  55                  60
Ser Thr Ala Asn Arg Ser Thr His Asn Glu Leu Glu Lys Asn Arg Arg 
 65                  70                  75                  80
Ala His Leu Arg Leu Cys Leu Glu Arg Leu Lys Val Leu Ile Pro Leu 
                 85                  90                  95
Gly Pro Asp Cys Thr Arg His Thr Thr Leu Gly Leu Leu Asn Lys Ala 
             100                105                110
Lys Ala His Ile Lys Lys Leu Glu Glu Ala Glu Arg Lys Ser Gln His 
         115                120                125
Gln Leu Glu Asn Leu Glu Arg Glu Gln Arg Phe Leu Lys Arg Arg Leu 
     130                135                140
Glu Gln Leu Gln Gly Pro Gln Glu Met Glu Arg Ile Arg Met Asp Ser 
 145                150                155                160
Ile Gly Ser Thr Ile Ser Ser Asp Arg Ser Asp Ser Glu Arg Glu Glu 
                 165                170                175
Ile Glu Val Asp Val Glu Ser Thr Glu Phe Ser His Gly Glu Val Asp 
             180                185                190
Asn Ile Ser Thr Thr Ser Ile Ser Asp Ile Asp Asp His Ser Ser Leu 
         195                200                205
Gln Ser Ile Gly Ser Asp Glu Gly Tyr Ser Ser Ala Ser Val Lys Leu 
     210                215                220
Ser Phe Thr Ser 
 225



<210> 5683
<211> 3773
<212> DNA
<213> Homo sapiens
<308> NM_006454
<400> 5683

ccgtcccgg  gcggacggg  gcgggcggg  ggatggagc  gaactccct  ctgatcctg  60
tggaggcgg  cgagtacct  gagcgcagg  atcgagagg  cgagcacgg  tacgcctcg  120
tgctgccct  cgacggcga  ttcgccagg  agaaaacaa  ggcggccgg  ctggtgcgc  180
aggccccga  caacaggtc  tcacacaac  agctagaaa  gcacagacg  gccaaactc  240
ggctgtacc  tgagcagct  aagcaactg  tgcccctgg  ccccgacag  acccgccac  300
ccacgctga  cctcctgaa  cgggccaag  tgcacatca  gaaactgga  gagcaggac  360
gccgggcac  gagcatcaa  gagcagctg  agcaggagc  tcgtttcct  aagcggcgc  420
tggagcagc  gtcggtgca  agcgtggag  gcgtgcgca  agatagcac  ggctctgct  480
tctccacgg  cgactcaga  caagaagtg  acatagagg  catggagtt  ggccctggt  540
agctggaca  tgttggcag  agcagtgac  cggacgacc  ctacagcct  cagagtggc  600
ccggcggcg  cagtggctt  gggccccac  gccggcggc  gggccgccc  gccctctcg  660
aggcccgtg  cctctgctc  ttggcctgc  tgcccgcca  ccacgcgtg  cagccctcc  720
gttctcctt  agttgacgc  agcctctcc  caggcccac  gctgtgcca  tctggaagc  780
ccagctgct  ctgggctgc  tggcactgc  cgcttgccg  tcagggcct  ccgagctgc  840
tgccccttc  agctgggca  agtcccctg  aaggaggca  ggcccagct  ccacatccg  900
agccctggt  agcatagcc  cccacggtc  gttctcaga  tcctaatca  tccagaagt  960
ttaaacgtc  ttgctgcaa  cctcggcag  tgccgtgtg  ggggcttaa  gaccaccac  1020
gggagctca  accccaacc  tggatccca  gagaaagga  tggaccgag  aaggaagga  1080
ggcaaggct  tctgtccat  cgtccgtct  tccacctac  tgtcagtcc  cataggctc  1140
tggcgtgga  aaggggtct  tgaagggcg  gaactgggt  agcacctgg  gcaggtggg  1200
ggttaaggt  cttcccact  cgcaggtgt  agaacctag  gctgggctc  cggggccag  1260
caggccagc  cagcccacg  cgagctggg  agcgtctgc  ctggtagga  tgtcagacg  1320
acacgcgca  gcacctaga  acacccact  atgtacatg  tcacacatg  agacacacc  1380
gggcgtccc  aggtcacat  ttctgggga  gatggcctt  aggggtcat  tggcaaaca  1440
cccctgggc  gtgcctgga  ccccctcta  ctcctgctc  cccacgccc  cccagtagt  1500
ctgcctgtc  gcacaggag  ggggcttct  ttcctggct  gggctgggg  gaactggag  1560
ctggttaag  tgcagccgc  gggtcctcg  gggcttact  atctccctt  tttaaacaa  1620
aagcaaaaa  gtaaaatgc  gcactgccc  gcagcccgg  tagggctcc  ggagccacc  1680
taggaaagg  cttctcatg  gctctgctg  ggcagcttc  gctggcaga  aggctttcc  1740
agaaaaaaa  aaaaaacca  ttttaaaaa  aagaaagcc  aaagactct  ggcctaggg  1800
cgtccgtgt  tgccgcctc  gtttcctgt  ccagatttt  gtattctat  ttcctagct  1860
ttgttgcgt  cttgtttgc  gaggggtgg  agccaccca  cgtctcagg  acctgtccc  1920
ccgtcacgt  gtcaaagtg  gccttgtgt  ttgtgtcag  ccttgccct  cccaccagc  1980
tgtccctcg  ggctcaggg  gccccaggc  tgcccagct  gtgctgtcc  cccatctcc  2040
gtgggcagc  cctcccggc  gccagggct  cctggaggc  atgcagcca  gcccctgtg  2100
gtggcacgg  ggggctgtg  cctggtccc  agtgttgcc  tccccagtg  ctggcaggg  2160
cctgcttgc  cactagaga  atggattct  acctgtcac  tgactcgag  cccctgctt  2220
ctggcctag  cgagggttc  aggtttcag  cactggcag  caatgaaga  tgtgctcgc  2280
gggtggtgc  ggcctggca  caggaggct  gcacccgcc  ttccttcct  acgtcctct  2340
tccttgggg  tggcccata  cagtgcctg  cgtgcctct  gtacatctg  agccaattc  2400
catatcatg  ggaaaattc  tgtctattt  cagtcgtac  catagacgc  ccaggatgg  2460
gggcccact  tggcggaag  gggtccctg  aaacaactc  ggcacagaa  ctgccctgc  2520
ggctgtagg  ggcatggtg  ctggagctg  ggggcatcc  aacgcgttg  gggtggttg  2580
gaggaggcc  gtctgcatc  ccttccggc  ccactgggg  ccaggggtg  ccagaaagg  2640
gcttcccct  cctgcctga  tctgtcccc  caggcttca  ttcaaacac  gtggcacct  2700
cgagcaagg  gggccgtgt  taaaagctt  cttccccag  cagcactgc  gggccctga  2760
gtggtcgtg  ccctgccct  aattcttga  gcaccagct  cctgcccca  cctccagtg  2820
ctgaggcag  taggggctt  tgctctcat  tctgaccag  agaatccac  cggtgacca  2880
tggtggccc  tcagcccac  ctcccggca  ctcagcctg  ggctcttga  gccgtggtt  2940
ccacgtgga  tgggaggca  tctcagcca  ccggggtgc  gttcagctg  ccctccctg  3000
catcagcag  tgggtgagg  gttgcccac  gggtggggg  ccgtgctag  agtcaccac  3060
tgctccaac  tcccactgc  ccctgtcag  ggcccaggc  gccatcact  gaggctgca  3120
ggaccaaga  gccatcacc  tgtctatag  gagcagaca  aagcagaac  gagcccggg  3180
ctcctgagc  tctgcgtgt  ccctcccag  ccacaccag  gctctcggc  actgagcac  3240
cagactcag  cttgggttc  ccagcctta  tggaaggca  ctcccgcat  ccaggataa  3300
ccccgcaaa  cacatagca  acccccgcc  tcctcgcag  gtgggagag  ctgcagcaa  3360
gctttgcct  tgcagaccc  atcttagtg  cacggtgct  gggcctgtg  ccccgggtg  3420
tggaaccct  taccggtct  tggccctag  gtccctgct  tgtctgccc  ggcccgtgc  3480
gtccgctgg  tgaggcagg  tcccccgtg  cctgcctcc  tctgtcagg  aacctggga  3540
cccctcccc  ctgcctgca  agaggaccc  gaccctcgg  cagcagggt  gccccaggt  3600
catgttggg  actagggca  gttccgtgc  agagtcggg  gccacacga  ggcctggtg  3660
cggtgaggg  ggcgtgcgc  agaggggga  aggggcccc  ggccacctg  ccaccgtgt  3720
ggccgtgct  tgtccttat  tcattgtaa  ataaataca  atttttata  ctc  3773



<210> 5684
<211> 209
<212> PRT
<213> Homo sapiens
<308> Q14582
<400> 5684

Met Glu Leu Asn Ser Leu Leu Ile Leu Leu Glu Ala Ala Glu Tyr Leu 
  1               5                  10                  15
Glu Arg Arg Asp Arg Glu Ala Glu His Gly Tyr Ala Ser Val Leu Pro 
             20                  25                  30
Phe Asp Gly Asp Phe Ala Arg Glu Lys Thr Lys Ala Ala Gly Leu Val 
         35                  40                  45
Arg Lys Ala Pro Asn Asn Arg Ser Ser His Asn Glu Leu Glu Lys His 
     50                  55                  60
Arg Arg Ala Lys Leu Arg Leu Tyr Leu Glu Gln Leu Lys Gln Leu Val 
 65                  70                  75                  80
Pro Leu Gly Pro Asp Ser Thr Arg His Thr Thr Leu Ser Leu Leu Lys 
                 85                  90                  95
Arg Ala Lys Val His Ile Lys Lys Leu Glu Glu Gln Asp Arg Arg Ala 
             100                105                110
Leu Ser Ile Lys Glu Gln Leu Gln Gln Glu His Arg Phe Leu Lys Arg 
         115                120                125
Arg Leu Glu Gln Leu Ser Val Gln Ser Val Glu Arg Val Arg Thr Asp 
     130                135                140
Ser Thr Gly Ser Ala Val Ser Thr Asp Asp Ser Glu Gln Glu Val Asp 
 145                150                155                160
Ile Glu Gly Met Glu Phe Gly Pro Gly Glu Leu Asp Ser Val Gly Ser 
                 165                170                175
Ser Ser Asp Ala Asp Asp His Tyr Ser Leu Gln Ser Gly Thr Gly Gly 
             180                185                190
Asp Ser Gly Phe Gly Pro His Cys Arg Arg Leu Gly Arg Pro Ala Leu 
         195                200                205
Ser 
     210



<210> 5685
<211> 386
<212> DNA
<213> Rattus norvegicus
<308> AA892154
<400> 5685

gaggtataa  aatctgtat  tatattaca  tgacataat  acacagcac  gccccatct  60
ttagacagg  gggatgggg  cccattcca  tctgcagct  aggtctcat  actcaccca  120
tgcactggc  ccaggcccc  tgtgtagcc  cagactctg  cacggaacc  gccctagaa  180
agcaagctc  accacctgc  ggttagaaa  acagaggca  acctagggc  catatggag  240
caaaacctc  gtgtcctct  ctgctagac  agctgggtc  gcagcagga  ggtgggtct  300
gtacatctg  accacctcc  acgaaagag  cccaagcct  agcctggag  tgcagactc  360
gttatggag  acacgtggc  cacatg  386



<210> 5686
<211> 228
<212> PRT
<213> Rattus norvegicus
<308> NP_037292
<400> 5686

Met Glu Arg Val Lys Met Ile Asn Val Gln Pro Met Leu Glu Ala Ala 
  1               5                  10                  15
Glu Phe Leu Glu Arg Arg Glu Arg Glu Cys Glu His Gly Tyr Ala Ser 
             20                  25                  30
Ser Phe Pro Ser Met Pro Ser Pro Arg Leu Gln His Ser Lys Pro Pro 
         35                  40                  45
Arg Arg Leu Ser Arg Ala Gln Lys His Ser Ser Gly Ser Ser Asn Thr 
     50                  55                  60
Ser Thr Ala Asn Arg Ser Thr His Asn Glu Leu Glu Lys Asn Arg Arg 
 65                  70                  75                  80
Ala His Leu Arg Leu Cys Leu Glu Arg Leu Lys Val Leu Ile Pro Leu 
                 85                  90                  95
Gly Pro Asp Cys Thr Arg His Thr Thr Leu Gly Leu Leu Asn Lys Ala 
             100                105                110
Lys Ala His Ile Lys Lys Leu Glu Glu Ala Glu Arg Lys Ser Gln His 
         115                120                125
Gln Leu Glu Asn Leu Glu Arg Glu Gln Arg Phe Leu Lys Arg Arg Leu 
     130                135                140
Glu Gln Leu Gln Gly Pro Gln Glu Met Glu Arg Ile Arg Met Asp Ser 
 145                150                155                160
Ile Gly Ser Thr Ile Ser Ser Asp Arg Ser Asp Ser Glu Arg Glu Glu 
                 165                170                175
Ile Glu Val Asp Val Glu Ser Thr Glu Phe Ser His Gly Glu Val Asp 
             180                185                190
Asn Ile Ser Thr Thr Ser Ile Ser Asp Ile Asp Asp His Ser Ser Leu 
         195                200                205
Gln Ser Ile Gly Ser Asp Glu Gly Tyr Ser Ser Ala Ser Val Lys Leu 
     210                215                220
Ser Phe Thr Ser 
 225



<210> 5687
<211> 3773
<212> DNA
<213> Homo sapiens
<308> NM_006454
<400> 5687

ccgtcccgg  gcggacggg  gcgggcggg  ggatggagc  gaactccct  ctgatcctg  60
tggaggcgg  cgagtacct  gagcgcagg  atcgagagg  cgagcacgg  tacgcctcg  120
tgctgccct  cgacggcga  ttcgccagg  agaaaacaa  ggcggccgg  ctggtgcgc  180
aggccccga  caacaggtc  tcacacaac  agctagaaa  gcacagacg  gccaaactc  240
ggctgtacc  tgagcagct  aagcaactg  tgcccctgg  ccccgacag  acccgccac  300
ccacgctga  cctcctgaa  cgggccaag  tgcacatca  gaaactgga  gagcaggac  360
gccgggcac  gagcatcaa  gagcagctg  agcaggagc  tcgtttcct  aagcggcgc  420
tggagcagc  gtcggtgca  agcgtggag  gcgtgcgca  agatagcac  ggctctgct  480
tctccacgg  cgactcaga  caagaagtg  acatagagg  catggagtt  ggccctggt  540
agctggaca  tgttggcag  agcagtgac  cggacgacc  ctacagcct  cagagtggc  600
ccggcggcg  cagtggctt  gggccccac  gccggcggc  gggccgccc  gccctctcg  660
aggcccgtg  cctctgctc  ttggcctgc  tgcccgcca  ccacgcgtg  cagccctcc  720
gttctcctt  agttgacgc  agcctctcc  caggcccac  gctgtgcca  tctggaagc  780
ccagctgct  ctgggctgc  tggcactgc  cgcttgccg  tcagggcct  ccgagctgc  840
tgccccttc  agctgggca  agtcccctg  aaggaggca  ggcccagct  ccacatccg  900
agccctggt  agcatagcc  cccacggtc  gttctcaga  tcctaatca  tccagaagt  960
ttaaacgtc  ttgctgcaa  cctcggcag  tgccgtgtg  ggggcttaa  gaccaccac  1020
gggagctca  accccaacc  tggatccca  gagaaagga  tggaccgag  aaggaagga  1080
ggcaaggct  tctgtccat  cgtccgtct  tccacctac  tgtcagtcc  cataggctc  1140
tggcgtgga  aaggggtct  tgaagggcg  gaactgggt  agcacctgg  gcaggtggg  1200
ggttaaggt  cttcccact  cgcaggtgt  agaacctag  gctgggctc  cggggccag  1260
caggccagc  cagcccacg  cgagctggg  agcgtctgc  ctggtagga  tgtcagacg  1320
acacgcgca  gcacctaga  acacccact  atgtacatg  tcacacatg  agacacacc  1380
gggcgtccc  aggtcacat  ttctgggga  gatggcctt  aggggtcat  tggcaaaca  1440
cccctgggc  gtgcctgga  ccccctcta  ctcctgctc  cccacgccc  cccagtagt  1500
ctgcctgtc  gcacaggag  ggggcttct  ttcctggct  gggctgggg  gaactggag  1560
ctggttaag  tgcagccgc  gggtcctcg  gggcttact  atctccctt  tttaaacaa  1620
aagcaaaaa  gtaaaatgc  gcactgccc  gcagcccgg  tagggctcc  ggagccacc  1680
taggaaagg  cttctcatg  gctctgctg  ggcagcttc  gctggcaga  aggctttcc  1740
agaaaaaaa  aaaaaacca  ttttaaaaa  aagaaagcc  aaagactct  ggcctaggg  1800
cgtccgtgt  tgccgcctc  gtttcctgt  ccagatttt  gtattctat  ttcctagct  1860
ttgttgcgt  cttgtttgc  gaggggtgg  agccaccca  cgtctcagg  acctgtccc  1920
ccgtcacgt  gtcaaagtg  gccttgtgt  ttgtgtcag  ccttgccct  cccaccagc  1980
tgtccctcg  ggctcaggg  gccccaggc  tgcccagct  gtgctgtcc  cccatctcc  2040
gtgggcagc  cctcccggc  gccagggct  cctggaggc  atgcagcca  gcccctgtg  2100
gtggcacgg  ggggctgtg  cctggtccc  agtgttgcc  tccccagtg  ctggcaggg  2160
cctgcttgc  cactagaga  atggattct  acctgtcac  tgactcgag  cccctgctt  2220
ctggcctag  cgagggttc  aggtttcag  cactggcag  caatgaaga  tgtgctcgc  2280
gggtggtgc  ggcctggca  caggaggct  gcacccgcc  ttccttcct  acgtcctct  2340
tccttgggg  tggcccata  cagtgcctg  cgtgcctct  gtacatctg  agccaattc  2400
catatcatg  ggaaaattc  tgtctattt  cagtcgtac  catagacgc  ccaggatgg  2460
gggcccact  tggcggaag  gggtccctg  aaacaactc  ggcacagaa  ctgccctgc  2520
ggctgtagg  ggcatggtg  ctggagctg  ggggcatcc  aacgcgttg  gggtggttg  2580
gaggaggcc  gtctgcatc  ccttccggc  ccactgggg  ccaggggtg  ccagaaagg  2640
gcttcccct  cctgcctga  tctgtcccc  caggcttca  ttcaaacac  gtggcacct  2700
cgagcaagg  gggccgtgt  taaaagctt  cttccccag  cagcactgc  gggccctga  2760
gtggtcgtg  ccctgccct  aattcttga  gcaccagct  cctgcccca  cctccagtg  2820
ctgaggcag  taggggctt  tgctctcat  tctgaccag  agaatccac  cggtgacca  2880
tggtggccc  tcagcccac  ctcccggca  ctcagcctg  ggctcttga  gccgtggtt  2940
ccacgtgga  tgggaggca  tctcagcca  ccggggtgc  gttcagctg  ccctccctg  3000
catcagcag  tgggtgagg  gttgcccac  gggtggggg  ccgtgctag  agtcaccac  3060
tgctccaac  tcccactgc  ccctgtcag  ggcccaggc  gccatcact  gaggctgca  3120
ggaccaaga  gccatcacc  tgtctatag  gagcagaca  aagcagaac  gagcccggg  3180
ctcctgagc  tctgcgtgt  ccctcccag  ccacaccag  gctctcggc  actgagcac  3240
cagactcag  cttgggttc  ccagcctta  tggaaggca  ctcccgcat  ccaggataa  3300
ccccgcaaa  cacatagca  acccccgcc  tcctcgcag  gtgggagag  ctgcagcaa  3360
gctttgcct  tgcagaccc  atcttagtg  cacggtgct  gggcctgtg  ccccgggtg  3420
tggaaccct  taccggtct  tggccctag  gtccctgct  tgtctgccc  ggcccgtgc  3480
gtccgctgg  tgaggcagg  tcccccgtg  cctgcctcc  tctgtcagg  aacctggga  3540
cccctcccc  ctgcctgca  agaggaccc  gaccctcgg  cagcagggt  gccccaggt  3600
catgttggg  actagggca  gttccgtgc  agagtcggg  gccacacga  ggcctggtg  3660
cggtgaggg  ggcgtgcgc  agaggggga  aggggcccc  ggccacctg  ccaccgtgt  3720
ggccgtgct  tgtccttat  tcattgtaa  ataaataca  atttttata  ctc  3773



<210> 5688
<211> 209
<212> PRT
<213> Homo sapiens
<308> Q14582
<400> 5688

Met Glu Leu Asn Ser Leu Leu Ile Leu Leu Glu Ala Ala Glu Tyr Leu 
  1               5                  10                  15
Glu Arg Arg Asp Arg Glu Ala Glu His Gly Tyr Ala Ser Val Leu Pro 
             20                  25                  30
Phe Asp Gly Asp Phe Ala Arg Glu Lys Thr Lys Ala Ala Gly Leu Val 
         35                  40                  45
Arg Lys Ala Pro Asn Asn Arg Ser Ser His Asn Glu Leu Glu Lys His 
     50                  55                  60
Arg Arg Ala Lys Leu Arg Leu Tyr Leu Glu Gln Leu Lys Gln Leu Val 
 65                  70                  75                  80
Pro Leu Gly Pro Asp Ser Thr Arg His Thr Thr Leu Ser Leu Leu Lys 
                 85                  90                  95
Arg Ala Lys Val His Ile Lys Lys Leu Glu Glu Gln Asp Arg Arg Ala 
             100                105                110
Leu Ser Ile Lys Glu Gln Leu Gln Gln Glu His Arg Phe Leu Lys Arg 
         115                120                125
Arg Leu Glu Gln Leu Ser Val Gln Ser Val Glu Arg Val Arg Thr Asp 
     130                135                140
Ser Thr Gly Ser Ala Val Ser Thr Asp Asp Ser Glu Gln Glu Val Asp 
 145                150                155                160
Ile Glu Gly Met Glu Phe Gly Pro Gly Glu Leu Asp Ser Val Gly Ser 
                 165                170                175
Ser Ser Asp Ala Asp Asp His Tyr Ser Leu Gln Ser Gly Thr Gly Gly 
             180                185                190
Asp Ser Gly Phe Gly Pro His Cys Arg Arg Leu Gly Arg Pro Ala Leu 
         195                200                205
Ser 
     210



<210> 5689
<211> 461
<212> DNA
<213> Rattus norvegicus
<308> AA892179
<400> 5689

acaaagaat  atcacttta  taattgagc  cgattcaga  tggtctaag  acacaaagc  60
tccggccaa  tcataagag  agctgaagt  atgagagtt  ttgtggcca  aggtccggg  120
agccatcac  tgcaacatc  actcccaga  gcactggag  ccgggcgag  acacctcag  180
ctcaggagg  cgggaactc  gtagaacag  tgttccagg  ctgagtgcc  ccaaccagc  240
tggctggac  aatgctgtg  gaacaggct  gcatcacaa  ggtaccacc  gaagggtgg  300
cagagggcc  cggggagga  ctacgtact  ctcctctcg  agcagccgc  gaagaatgt  360
tttcttatt  ttgggccag  tgtacacgt  agtgttctg  agccaggtc  gcacgtgct  420
cttcttggc  tttgggaag  gcacaggga  gaacctgaa  t  461



<210> 5690
<211> 2381
<212> DNA
<213> Homo sapiens
<308> AL050289
<400> 5690

ttttgagca  aggcttcct  ggctccgta  aaatttgca  acagcttcc  cttcctgct  60
cagagcctg  tcttctact  acctgggcc  ggagaaggt  gagggagac  agaagccgc  120
gagagccga  taccctccg  gcccagtct  tctgtccgt  gtggatcta  gaaactaga  180
tgaaccgaa  cattcctgt  gaggttgat  aatcagaac  atacccaag  cagttgctg  240
aaccaatcc  agaatattc  ccggaagag  aatcagaac  acctgctcc  aatataagg  300
acatggcac  caacagctt  tctgcaccc  caatgcttc  caattcctc  ggagacttt  360
ctcaagctc  ctcaaccct  aaacttgca  atcaccagc  gcctgtatc  cggcaggtc  420
cctgcctgc  cactcaagt  ctggaggac  gtgaagaca  tttctgcag  agacaccca  480
gcctgggca  agctttccc  tctgggtgc  ctgcagtca  cgagcctgc  tctgagtct  540
tggttggag  cctccctgc  gagcatcag  tttcattta  ggaaaaacg  aatcaatgg  600
tggtatctc  gctttcagc  gcttctcct  acactggcc  tgactcaga  aaatcagac  660
aaagtttac  taatgcctc  gcagactcc  tgggcggta  ccaggagat  gtgcaacgg  720
cccagcctc  caggaaccg  gcaggcctg  atctgccaa  catagacac  ggatatgat  780
cccagcccc  ggatgtcct  ggcatcagg  agctggaaa  gcccctgcc  ctcacctcc  840
tgtgttacc  ccaggacct  cccagacct  tcaggtcca  ggagttccc  cagtttgaa  900
ctcagaggt  tccagcatg  gcacagatg  tgcctccca  tctttcccc  catgctcca  960
ggaactatc  ttaccattg  cctggaagt  ccgatcacc  ggtgccata  ggccatgac  1020
accctcgag  agcctacca  caagtgatc  agccggctc  gcctgggca  cccctgcct  1080
gagccagtg  gagaggcct  caccctgtg  agaaggtta  cctgaatta  cccagcccc  1140
gggaccaag  agagaggcc  gcacagaga  actgctcct  tccggggct  ccaaggcac  1200
aggaccagc  acatcacca  ccacctaat  gagctggtg  tcctgggga  tccttggag  1260
gccctgcag  gctgagacc  caggttccc  agcctccgt  cccagctgc  gtgcctaga  1320
cccctagca  ccctccagc  agaggaact  taaaaacaa  caatttgcc  gaagaattg  1380
ggaaagtct  tatcactta  tcgatggac  cagctatgg  ggtggtgaa  ttcgtgaac  1440
ttttgttgg  aaatggctt  caaactgca  ttgacatat  tgaggatag  atccgaggc  1500
ttgatatca  taaatggat  gagcgctac  ttagggata  gaccgtgat  ataatcgta  1560
caatcagcc  caaatacaa  caggacgtg  aaggcgctg  gtcgcagct  gacgaggat  1620
agcatggct  acatactaa  tacattcat  gaatgatgc  gattgagtt  ataaaacaa  1680
gaagcatga  tttcagatt  atccctgtg  tcttcccaa  tgctaagaa  gagcatgtg  1740
ccacctggc  tcagaacac  catgtctac  gctggccca  gaataaaaa  aacatcctg  1800
tgcggctgc  gagagagga  gagtatgtg  ctcctccac  ggggcctct  cccaccctt  1860
aggtggttc  cttgtgaca  cgttcatcc  cagatcact  aggccaggc  atgtttggg  1920
ccttgttct  acagcattc  ggctgaggc  ggtcggtag  actcctggc  ggttttttt  1980
tgttcctcc  cgagaggcc  tctggcccc  aggaaacct  ttgtgcaga  ctcttcccc  2040
gagacctcc  cacaccctg  ctttgaagt  gagtctgtg  ctgctctgc  ttctctgct  2100
ttaaaaaaa  cattgcagg  gccagtgtc  catatgttc  tcctgacag  ttgatgtgt  2160
cattctggg  ctctcagtg  ttagcaagt  gataatgta  gggatgtgg  agcaaatgg  2220
aatgactac  aacactctc  tatcaatca  ttcaggcta  ttttatgag  tagccagat  2280
cttgtgtat  ctcagacca  actgattca  gtacaaata  taaaatgtt  actcttttg  2340
aaaaaaaaa  aaaaaaaaa  aaagaaaaa  aaaaaaaaa  a  2381



<210> 5691
<211> 574
<212> PRT
<213> Homo sapiens
<308> O43734
<400> 5691

Met Pro Pro Gln Leu Gln Glu Thr Arg Met Asn Arg Ser Ile Pro Val 
  1               5                  10                  15
Glu Val Asp Glu Ser Glu Pro Tyr Pro Ser Gln Leu Leu Lys Pro Ile 
             20                  25                  30
Pro Glu Tyr Ser Pro Glu Glu Glu Ser Glu Pro Pro Ala Pro Asn Ile 
         35                  40                  45
Arg Asn Met Ala Pro Asn Ser Leu Ser Ala Pro Thr Met Leu His Asn 
     50                  55                  60
Ser Ser Gly Asp Phe Ser Gln Ala His Ser Thr Leu Lys Leu Ala Asn 
 65                  70                  75                  80
His Gln Arg Pro Val Ser Arg Gln Val Thr Cys Leu Arg Thr Gln Val 
                 85                  90                  95
Leu Glu Asp Ser Glu Asp Ser Phe Cys Arg Arg His Pro Gly Leu Gly 
             100                105                110
Lys Ala Phe Pro Ser Gly Cys Ser Ala Val Ser Glu Pro Ala Ser Glu 
         115                120                125
Ser Val Val Gly Ala Leu Pro Ala Glu His Gln Phe Ser Phe Met Glu 
     130                135                140
Lys Arg Asn Gln Trp Leu Val Ser Gln Leu Ser Ala Ala Ser Pro Asp 
 145                150                155                160
Thr Gly His Asp Ser Asp Lys Ser Asp Gln Ser Leu Pro Asn Ala Ser 
                 165                170                175
Ala Asp Ser Leu Gly Gly Ser Gln Glu Met Val Gln Arg Pro Gln Pro 
             180                185                190
His Arg Asn Arg Ala Gly Leu Asp Leu Pro Thr Ile Asp Thr Gly Tyr 
         195                200                205
Asp Ser Gln Pro Gln Asp Val Leu Gly Ile Arg Gln Leu Glu Arg Pro 
     210                215                220
Leu Pro Leu Thr Ser Val Cys Tyr Pro Gln Asp Leu Pro Arg Pro Leu 
 225                230                235                240
Arg Ser Arg Glu Phe Pro Gln Phe Glu Pro Gln Arg Tyr Pro Ala Cys 
                 245                250                255
Ala Gln Met Leu Pro Pro Asn Leu Ser Pro His Ala Pro Trp Asn Tyr 
             260                265                270
His Tyr His Cys Pro Gly Ser Pro Asp His Gln Val Pro Tyr Gly His 
         275                280                285
Asp Tyr Pro Arg Ala Ala Tyr Gln Gln Val Ile Gln Pro Ala Leu Pro 
     290                295                300
Gly Gln Pro Leu Pro Gly Ala Ser Val Arg Gly Leu His Pro Val Gln 
 305                310                315                320
Lys Val Ile Leu Asn Tyr Pro Ser Pro Trp Asp Gln Glu Glu Arg Pro 
                 325                330                335
Ala Gln Arg Asp Cys Ser Phe Pro Gly Leu Pro Arg His Gln Asp Gln 
             340                345                350
Pro His His Gln Pro Pro Asn Arg Ala Gly Ala Pro Gly Glu Ser Leu 
         355                360                365
Glu Cys Pro Ala Glu Leu Arg Pro Gln Val Pro Gln Pro Pro Ser Pro 
     370                375                380
Ala Ala Val Pro Arg Pro Pro Ser Asn Pro Pro Ala Arg Gly Thr Leu 
 385                390                395                400
Lys Thr Ser Asn Leu Pro Glu Glu Leu Arg Lys Val Phe Ile Thr Tyr 
                 405                410                415
Ser Met Asp Thr Ala Met Glu Val Val Lys Phe Val Asn Phe Leu Leu 
             420                425                430
Val Asn Gly Phe Gln Thr Ala Ile Asp Ile Phe Glu Asp Arg Ile Arg 
         435                440                445
Gly Ile Asp Ile Ile Lys Trp Met Glu Arg Tyr Leu Arg Asp Lys Thr 
     450                455                460
Val Met Ile Ile Val Ala Ile Ser Pro Lys Tyr Lys Gln Asp Val Glu 
 465                470                475                480
Gly Ala Glu Ser Gln Leu Asp Glu Asp Glu His Gly Leu His Thr Lys 
                 485                490                495
Tyr Ile His Arg Met Met Gln Ile Glu Phe Ile Lys Gln Gly Ser Met 
             500                505                510
Asn Phe Arg Phe Ile Pro Val Leu Phe Pro Asn Ala Lys Lys Glu His 
         515                520                525
Val Pro Thr Trp Leu Gln Asn Thr His Val Tyr Ser Trp Pro Lys Asn 
     530                535                540
Lys Lys Asn Ile Leu Leu Arg Leu Leu Arg Glu Glu Glu Tyr Val Ala 
 545                550                555                560
Pro Pro Arg Gly Pro Leu Pro Thr Leu Gln Val Val Pro Leu 
                 565                570



<210> 5692
<211> 587
<212> DNA
<213> Rattus norvegicus
<308> AA892248
<400> 5692

agggtttgc  gaaaatggc  gtatatagg  tgaattatc  agaaggggt  aggtagaac  60
gggtttatc  attatagaa  aggctcctc  aaatggata  aaagtaccg  caagtcctt  120
gagttttaa  ctgtagcta  tagttctct  gcaaataat  ttgtaggtt  aattattaa  180
gtttagggc  aagcatagt  gggtatcta  tcccagttt  ggtcttagc  atcgtgcat  240
atataaatg  ttagaatta  tttcgttat  gggcttaag  cctaacaat  aattttcac  300
tataacttg  attttaatt  tattatgac  tttatagtt  gcacgtttt  cgccgaaaa  360
aattagttt  ggttaatcg  atgaccgcg  tggctggca  gaaatttac  aaccctgac  420
ggtatagct  agtcaaact  tcgttcagt  cctaatatt  atcactgct  agtcccgtg  480
gggtgtggc  aagcaaggc  tcttgagct  tattatgtg  ttgatgccc  ctccttaag  540
tttacgcaa  tgtttaagg  attttacac  ggtttatgg  tgtttgc  587



<210> 5693
<211> 587
<212> DNA
<213> Rattus norvegicus
<308> AA892248
<400> 5693

agggtttgc  gaaaatggc  gtatatagg  tgaattatc  agaaggggt  aggtagaac  60
gggtttatc  attatagaa  aggctcctc  aaatggata  aaagtaccg  caagtcctt  120
gagttttaa  ctgtagcta  tagttctct  gcaaataat  ttgtaggtt  aattattaa  180
gtttagggc  aagcatagt  gggtatcta  tcccagttt  ggtcttagc  atcgtgcat  240
atataaatg  ttagaatta  tttcgttat  gggcttaag  cctaacaat  aattttcac  300
tataacttg  attttaatt  tattatgac  tttatagtt  gcacgtttt  cgccgaaaa  360
aattagttt  ggttaatcg  atgaccgcg  tggctggca  gaaatttac  aaccctgac  420
ggtatagct  agtcaaact  tcgttcagt  cctaatatt  atcactgct  agtcccgtg  480
gggtgtggc  aagcaaggc  tcttgagct  tattatgtg  ttgatgccc  ctccttaag  540
tttacgcaa  tgtttaagg  attttacac  ggtttatgg  tgtttgc  587



<210> 5694
<211> 625
<212> DNA
<213> Rattus norvegicus
<308> AA892259
<400> 5694

gaaaaagca  cttgtttta  taaaagatg  gaacaatac  ttttaagtg  atacaaaaa  60
aaatatttg  attacagag  tgggcacac  tgtactctg  gaggcaggt  gggggcgtg  120
cgtgtgaca  ggggccagt  aacaggtcg  cctggcttt  gaagagatg  tcctgcttt  180
gctgagtgg  gagaagcag  ccccaggat  ctgttttca  gagtcacat  ctatggtga  240
cctgactgt  gaacaggac  cacacccag  accattcac  atgaatgtc  ccaacgtcc  300
taacttttc  ggttgtaag  tgtggccta  cactcgtag  tgcaccgga  tgtcttcca  360
accctcctg  ttctcccca  ttctcagaa  aacagtcaa  aggttaagg  gttccctgc  420
cttccccag  gaatgctga  cacattaga  gctcctcta  ctgcactga  cctgtaacc  480
aggttggtt  cagagtaga  caaatagaa  aggtctctc  tgtcctcac  caaaaggag  540
taatgatgt  ccctgtccc  acatctgct  ggcctctgt  cctgctgtg  actgatgca  600
actaaaccc  tgacaggga  tccta  625



<210> 5695
<211> 328
<212> PRT
<213> Rattus norvegicus
<308> NP_036723
<400> 5695

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
  1               5                  10                  15
Asn Ser Asn Gln Ile Pro Gly Leu Ser Trp Ile Asn Lys Glu Glu Met 
             20                  25                  30
Ile Phe Gln Ile Pro Trp Lys His Ala Ala Leu His Gly Trp Asp Ile 
         35                  40                  45
Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg 
     50                  55                  60
Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn 
 65                  70                  75                  80
Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                 85                  90                  95
Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu 
             100                105                110
Pro Pro Leu Thr Lys Asn Gln Arg Lys Glu Arg Lys Ser Lys Ser Ser 
         115                120                125
Arg Asp Thr Lys Ser Lys Thr Lys Arg Lys Leu Cys Gly Asp Ser Ser 
     130                135                140
Pro Asp Thr Leu Ser Asp Gly Leu Ser Ser Ser Thr Leu Pro Asp Asp 
 145                150                155                160
His Ser Ser Tyr Thr Ala Gln Gly Tyr Leu Gly Gln Asp Leu Asp Met 
                 165                170                175
Asp Arg Asp Ile Thr Pro Ala Leu Ser Pro Cys Val Val Ser Ser Ser 
             180                185                190
Leu Ser Glu Trp His Met Gln Met Asp Ile Met Pro Asp Ser Thr Thr 
         195                200                205
Asp Leu Tyr Asn Leu Gln Val Ser Pro Met Pro Ser Thr Ser Glu Ala 
     210                215                220
Ala Thr Asp Glu Asp Glu Glu Gly Lys Leu Pro Glu Asp Ile Met Lys 
 225                230                235                240
Leu Phe Glu Gln Ser Glu Trp Gln Pro Thr His Val Asp Gly Lys Gly 
                 245                250                255
Tyr Leu Leu Asn Glu Pro Gly Ala Gln Leu Ser Thr Val Tyr Gly Asp 
             260                265                270
Phe Ser Cys Lys Glu Glu Pro Glu Ile Asp Ser Pro Gly Gly Asp Ile 
         275                280                285
Glu Ile Gly Ile Gln Arg Val Phe Thr Glu Met Lys Asn Met Asp Pro 
     290                295                300
Val Met Trp Met Asp Thr Leu Leu Gly Asn Ser Thr Arg Pro Pro Ser 
 305                310                315                320
Ile Gln Ala Ile Pro Cys Ala Pro 
                 325



<210> 5696
<211> 1538
<212> DNA
<213> Homo sapiens
<308> M91196
<400> 5696

atggatggg  gaaccgggc  gcgagacgg  ggcaggacg  cggcaggat  tgtgaccgg  60
atggtggtc  gcggcttcg  cagtggctg  tcgagcaga  tgacagtag  atgtatcca  120
gactgattt  ggagaatga  gagaagagc  tgttccgga  cccttggaa  cacgctggc  180
agcaagatt  taatcagga  gtggatgcc  ccattttta  ggcctgggc  gtttttaaa  240
ggaagttta  agaagggga  aaagctgaa  cagccactt  gaagacgag  ttacgctgt  300
ctttgaata  gagcccaga  tttgaggaa  tgacggacc  gtcccaact  gacatttcc  360
agccataca  agtttaccg  attgttcct  aggaagagc  aaaatgcaa  ctaggcgtg  420
caactgctg  ctgcgtgaa  gaagttaca  agatggagt  cggtcgctc  gaaatcgac  480
agctgatca  ggagccttc  gtggacgat  acatgggga  gatcaaaag  agcccttcc  540
cgccggagg  ctgtcggag  cagctcctt  cagactggt  ggcgcagca  cccagcaca  600
gcgtgccgc  ggtgacggg  tacaccacc  acgacgcgc  ccattcagc  ttctcccag  660
tggtgatca  cttctacta  gggggcaag  tggtgggcc  ggccaccac  acctgcccc  720
agggctgcc  cctgtccct  agccagcct  ggctgcccg  caccaagct  tatgggccc  780
agggcctgg  gctggtgcg  ttcccgccg  ccgacgcca  ccccagcga  cgacagagg  840
aggtgacgc  gaagctgtt  gggcacctg  agcgcgggg  gctgctgca  agcagccgg  900
agggcgtgt  cgtcaagcg  ctgtgccag  gccgcgtgt  ctgcagcgg  aacgccgtg  960
tgtgcaaag  caggcccaa  aagctggag  gtgatgagg  ggtccaggt  ttcgacacc  1020
gccagttct  ccgagagct  cagcagttc  ataacagcc  gggccggct  cctgacggc  1080
gggtggtgc  gtgctttgg  gaagagttt  cggatatgg  ccccttgcg  tccaaactc  1140
ttctcgtgc  gattgagca  ctgtatgtc  ggcaactgg  agaagaggc  gggaagagc  1200
gtggagccg  ctctgtgat  caggccccc  aggagccgc  gccagacca  gtcttccgg  1260
tgtttccag  tatttgtgc  tcacaccag  gatcatttt  cagagaaaa  caacagatc  1320
ccgtctaag  gcgtcgctt  ggcgcccca  cccgtctgc  tcctgcatc  atctccctg  1380
tacagtggc  cgcatcatg  ttaaagaat  tggatccct  tgtctgggg  gggatgcct  1440
actttgcac  taatttaat  agggcattc  cggaggagt  gacgtttaa  acgaagtgg  1500
gcatagccc  gccgagatg  cggtgatgg  ctgatgcg  1538



<210> 5697
<211> 426
<212> PRT
<213> Homo sapiens
<308> Q02556
<400> 5697

Met Cys Asp Arg Asn Gly Gly Arg Arg Leu Arg Gln Trp Leu Ile Glu 
  1               5                  10                  15
Gln Ile Asp Ser Ser Met Tyr Pro Gly Leu Ile Trp Glu Asn Glu Glu 
             20                  25                  30
Lys Ser Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr 
         35                  40                  45
Asn Gln Glu Val Asp Ala Ser Ile Phe Lys Ala Trp Ala Val Phe Lys 
     50                  55                  60
Gly Lys Phe Lys Glu Gly Asp Lys Ala Glu Pro Ala Thr Trp Lys Thr 
 65                  70                  75                  80
Arg Leu Arg Cys Ala Leu Asn Lys Ser Pro Asp Phe Glu Glu Val Thr 
                 85                  90                  95
Asp Arg Ser Gln Leu Asp Ile Ser Glu Pro Tyr Lys Val Tyr Arg Ile 
             100                105                110
Val Pro Glu Glu Glu Gln Lys Cys Lys Leu Gly Val Ala Thr Ala Gly 
         115                120                125
Cys Val Asn Glu Val Thr Glu Met Glu Cys Gly Arg Ser Glu Ile Asp 
     130                135                140
Glu Leu Ile Lys Glu Pro Ser Val Asp Asp Tyr Met Gly Met Ile Lys 
 145                150                155                160
Arg Ser Pro Ser Pro Pro Glu Ala Cys Arg Ser Gln Leu Leu Pro Asp 
                 165                170                175
Trp Trp Ala Gln Gln Pro Ser Thr Gly Val Pro Leu Val Thr Gly Tyr 
             180                185                190
Thr Thr Tyr Asp Ala His His Ser Ala Phe Ser Gln Met Val Ile Ser 
         195                200                205
Phe Tyr Tyr Gly Gly Lys Leu Val Gly Gln Ala Thr Thr Thr Cys Pro 
     210                215                220
Glu Gly Cys Arg Leu Ser Leu Ser Gln Pro Gly Leu Pro Gly Thr Lys 
 225                230                235                240
Leu Tyr Gly Pro Glu Gly Leu Glu Leu Val Arg Phe Pro Pro Ala Asp 
                 245                250                255
Ala Ile Pro Ser Glu Arg Gln Arg Gln Val Thr Arg Lys Leu Phe Gly 
             260                265                270
His Leu Glu Arg Gly Val Leu Leu His Ser Ser Arg Gln Gly Val Phe 
         275                280                285
Val Lys Arg Leu Cys Gln Gly Arg Val Phe Cys Ser Gly Asn Ala Val 
     290                295                300
Val Cys Lys Gly Arg Pro Asn Lys Leu Glu Arg Asp Glu Val Val Gln 
 305                310                315                320
Val Phe Asp Thr Ser Gln Phe Phe Arg Glu Leu Gln Gln Phe Tyr Asn 
                 325                330                335
Ser Gln Gly Arg Leu Pro Asp Gly Arg Val Val Leu Cys Phe Gly Glu 
             340                345                350
Glu Phe Pro Asp Met Ala Pro Leu Arg Ser Lys Leu Ile Leu Val Gln 
         355                360                365
Ile Glu Gln Leu Tyr Val Arg Gln Leu Ala Glu Glu Ala Gly Lys Ser 
     370                375                380
Cys Gly Ala Gly Ser Val Met Gln Ala Pro Glu Glu Pro Pro Pro Asp 
 385                390                395                400
Gln Val Phe Arg Met Phe Pro Asp Ile Cys Ala Ser His Gln Arg Ser 
                 405                410                415
Phe Phe Arg Glu Asn Gln Gln Ile Thr Val 
             420                425



<210> 5698
<211> 554
<212> DNA
<213> Rattus norvegicus
<308> AA892260
<400> 5698

aaggcaaac  gtgccgcct  gaatcttta  tcaaaaggg  atcagcatt  gacaaggcc  60
acaattcaa  agcaaaatg  acttttcct  gaagtgccg  tcttcagct  ctccctatg  120
tcacctgcc  gagaacttg  tgtcagttc  ctatcttca  agacgcttc  ctgcctgcc  180
catctgacc  gacccaact  tggagaggg  agggctgga  acatagcct  ctggcatag  240
aggctctgc  accctctct  gtgcccctg  cagcattca  gcctcctga  gagggtggg  300
atggggctt  agaacagag  ggagggaaa  ctgggctgg  agaagacac  ctccaggca  360
cccagcact  ttagcccag  gtcccaggg  cctggctct  ttggtcttg  cccccacat  420
ccctcccca  agggtcagt  gatcttctg  cgactgggt  cgatggcct  tttgatgaa  480
gagaagaca  ccaggatgc  taagcgctt  cctcgcttg  ctttggtga  gtaattgga  540
accacgtca  cgcc  554



<210> 5699
<211> 554
<212> DNA
<213> Rattus norvegicus
<308> AA892260
<400> 5699

aaggcaaac  gtgccgcct  gaatcttta  tcaaaaggg  atcagcatt  gacaaggcc  60
acaattcaa  agcaaaatg  acttttcct  gaagtgccg  tcttcagct  ctccctatg  120
tcacctgcc  gagaacttg  tgtcagttc  ctatcttca  agacgcttc  ctgcctgcc  180
catctgacc  gacccaact  tggagaggg  agggctgga  acatagcct  ctggcatag  240
aggctctgc  accctctct  gtgcccctg  cagcattca  gcctcctga  gagggtggg  300
atggggctt  agaacagag  ggagggaaa  ctgggctgg  agaagacac  ctccaggca  360
cccagcact  ttagcccag  gtcccaggg  cctggctct  ttggtcttg  cccccacat  420
ccctcccca  agggtcagt  gatcttctg  cgactgggt  cgatggcct  tttgatgaa  480
gagaagaca  ccaggatgc  taagcgctt  cctcgcttg  ctttggtga  gtaattgga  540
accacgtca  cgcc  554



<210> 5700
<211> 433
<212> DNA
<213> Rattus norvegicus
<308> AA892268
<400> 5700

gaataccag  atataaaac  agtccttta  tttttcaag  gttttaaaa  acaaattta  60
acttaagcc  gccttgaag  taagcataa  aattaccaa  ttaaaccaa  aaccaaacc  120
aaagacccc  aacccacaa  atcggaagc  ctggctctg  gcacagctc  acccaggcg  180
gcatggggg  acacagcag  agagagggg  cactgtctg  aactgcgtc  tctccttac  240
gggagagcg  aaaataaat  ggatcacca  tgccttcta  gcatctgcc  agccttctt  300
cagctcaca  gaaagctga  aggcgatga  ctgggagct  cttccctca  acacgagca  360
ggccacagt  actcaacga  cattcccat  cagggtgta  gcattttca  ttttacctt  420
taatttctt  tac  433



<210> 5701
<211> 3068
<212> DNA
<213> Homo sapiens
<308> S59184
<400> 5701

aacggtatc  ataagcttg  tatcgaatt  cgcaccccc  gctcggggc  gtgagcggc  60
cggggccgg  ggtgggcgg  ggtgcggcg  gcggccgac  ctcctcttc  gcggcggcg  120
cggcggcgg  ccatgcgtg  ggcggcgcg  ctggggcgg  cgggccgga  ttgcctccc  180
gggcccgcg  tgagggccg  cgccgcgcc  gccctgctg  ttgctcgtt  cgctgttgc  240
gctgctgcc  gcctgcgtg  cgccgcccg  ccgcggccc  cggagctgc  gtcggcttc  300
gcggggccc  gcgtgagtc  ctacctgag  gaggacgag  tgcgccggc  gatcggtct  360
gatgcagaa  tttattatg  gagaaatga  cttattagt  actacgctc  atcctttaa  420
ctgttagta  ccagtgaga  aaatttcct  cacttcacc  ggcatgcga  gtccaaggt  480
gaatataag  tgggattcc  agtggacaa  gttttggca  tggatatgc  ccaggtcaa  540
atttctgtt  agggggaag  tccacgcac  ttatcagtg  ttcgggtag  gctttcctg  600
actggcaaa  tagattctg  agttatgat  ctaatgcag  tcaacttga  agtaaattc  660
tcaaaaaat  ttaccgtct  aaattttaa  cgaaggaaa  tgtgctaca  aaaacttga  720
gaagtaaaa  cttcagcct  ggacaaaaa  actagcaga  ctatttatg  tcctgtaca  780
gcagctcca  ccacttcta  gcgtgtgtt  tatattagt  taggggttt  ttgtgcagt  840
atatttctc  tagcaataa  attagctgt  ttgcacctt  ataatatga  aaggattga  900
ctggatgac  gcattagtg  cagcagtag  tcccaaggg  tgtctcagc  atccaccca  960
acgactcag  atctgagag  agacacgcc  aacaatgca  ctcctatca  cagttatcc  1020
accttgcgg  tagagaaga  cgacttgag  agtgtcact  ttttggagg  caaaggcaa  1080
gtgaaggat  tagcaatat  cagagagag  ataactcta  aagatgtac  ccaagaagg  1140
acttttggg  gtattttcc  tgggatttt  atagatgaa  aagatccaa  taaagaaaa  1200
caagcattt  tcaaaacag  taaagatca  gcttctgaa  ttcaggtga  aatgatgct  1260
actgaaagt  gtaagctgc  aggtcttca  cacagaaat  ttcttccta  tactcatgt  1320
tgtatagaa  aaggagaaa  gcccatggt  atattgcct  acatgaatt  ggggaatct  1380
aaattgttt  tacgacagt  caagttagt  gaggccaat  atccacagg  aatttctca  1440
caagacctg  tacacatgg  tattcagat  gcctgtgga  tgagctacc  ggccagaag  1500
gaagtcatc  acaaagacc  ggctgccag  aactgtgtc  ttgatgaca  acttcaagt  1560
aagatcaca  acaatgccc  ctccagaga  ttgttcccc  tggactatc  ctgtctggg  1620
gacaatgaa  acaggccag  tcgttggat  gctcttgaa  gtctggtta  taacgagtt  1680
tctagcgct  gtgatgtgt  ggcctttgg  gtgaacagc  tgtgggaac  catgactct  1740
ggccagact  cctacacgt  ggacattga  cccttcgag  tggcggcat  cctgaaaga  1800
ggttaccga  tagcccagc  aatcacctg  cctgatgaa  tatttgctg  gatggcctg  1860
tgctgggcc  tagatccag  ggagaggcc  aggtttcag  agctggtac  gtgcctaac  1920
gagtttcat  cagccctgg  ggcctacgt  tgactcctc  ccaatccca  accatcagg  1980
agaaggtgc  tgtcggggc  cacttgaag  ctgtcaggg  tgctttgta  atctaacac  2040
acgccaaca  aagcacatt  gtcttccag  acaccgtgc  ttagaaatg  tttagaatc  2100
gaacttttt  agacagact  aataatgtg  catattttc  agatatcac  tttattagg  2160
tgaactgaa  gggtttttg  aaatttttt  gccaaaatt  tttaaaaca  acttacttt  2220
gactagggg  acattctta  aaaataaat  aacagtttt  aaaattgtt  agacacaga  2280
atttggaat  agctatctt  gggccaact  ctttttatt  ttttacttc  tcaaggtga  2340
gtaagtgac  ttgtttaga  acagatatt  ggaattagc  tatcttagt  ccaactgct  2400
tttattttt  tccttcatc  aggtgatgt  agtgactca  ctttaaagt  tttttagtg  2460
tatttttta  cactactct  ggaaatggt  tgtcttcaa  atgcaatac  tttcttaga  2520
aaggaaaaa  agcataaaa  gatacctgg  ctgccttgt  caagaaaac  gaatattag  2580
ggaagaaaa  ttaaagaaa  gctagagaa  aaaaaaatt  tttaaaaaa  acttattag  2640
agcaaactg  ccttgcatg  aaaactgtt  atttttttc  gtgaaaaag  aattctgct  2700
tcgtgtttt  gggaaagca  gaactgagt  cattacatc  ttaatttgg  agaaattag  2760
ctttctgtg  accagatgt  gtttggggc  gatctgtag  aaacaatgg  gattttatt  2820
atttttact  tctggaaaa  gagataata  aattccaga  agtgaactc  tatttctaa  2880
gtaagatcc  ttttatgca  ctagaatat  ctatgcaca  agcgggtgc  tgagttgtt  2940
tcgtttttt  tttgttttt  aaatgtaaa  tggtaaatt  tgtgcttat  ttcaaggct  3000
gcttaagta  aaaattgtt  tttaaacac  tgaaaaatt  aaggatttg  tttatatta  3060
aaaaaaaa  3068



<210> 5702
<211> 604
<212> PRT
<213> Homo sapiens
<308> P34925
<400> 5702

Met Arg Gly Ala Ala Arg Leu Gly Arg Pro Gly Arg Ser Cys Leu Pro 
  1               5                  10                  15
Gly Pro Ala Leu Arg Ala Ala Ala Ala Pro Ala Leu Leu Leu Ala Arg 
             20                  25                  30
Cys Ala Val Ala Ala Ala Ala Gly Leu Arg Ala Ala Ala Arg Pro Arg 
         35                  40                  45
Pro Pro Glu Leu Gln Ser Ala Ser Ala Gly Pro Ser Val Ser Leu Tyr 
     50                  55                  60
Leu Ser Glu Asp Glu Val Arg Arg Leu Ile Gly Leu Asp Ala Glu Leu 
 65                  70                  75                  80
Tyr Tyr Val Arg Asn Asp Leu Ile Ser His Tyr Ala Leu Ser Phe Asn 
                 85                  90                  95
Leu Leu Val Pro Ser Glu Thr Asn Phe Leu His Phe Thr Trp His Ala 
             100                105                110
Lys Ser Lys Val Glu Tyr Lys Leu Gly Phe Gln Val Asp Asn Val Leu 
         115                120                125
Ala Met Asp Met Pro Gln Val Asn Ile Ser Val Gln Gly Glu Val Pro 
     130                135                140
Arg Thr Leu Ser Val Phe Arg Val Glu Leu Ser Cys Thr Gly Lys Val 
 145                150                155                160
Asp Ser Glu Val Met Ile Leu Met Gln Leu Asn Leu Thr Val Asn Ser 
                 165                170                175
Ser Lys Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys Met Cys Tyr 
             180                185                190
Lys Lys Leu Glu Glu Val Lys Thr Ser Ala Leu Asp Lys Asn Thr Ser 
         195                200                205
Arg Thr Ile Tyr Asp Pro Val His Ala Ala Pro Thr Thr Ser Thr Arg 
     210                215                220
Val Phe Tyr Ile Ser Val Gly Val Cys Cys Ala Val Ile Phe Leu Val 
 225                230                235                240
Ala Ile Ile Leu Ala Val Leu His Leu His Asn Met Lys Arg Ile Glu 
                 245                250                255
Leu Asp Asp Ser Ile Ser Ala Ser Ser Ser Ser Gln Gly Leu Ser Gln 
             260                265                270
Pro Ser Thr Gln Thr Thr Gln Tyr Leu Arg Ala Asp Thr Pro Asn Asn 
         275                280                285
Ala Thr Pro Ile Thr Ser Tyr Pro Thr Leu Arg Ile Glu Lys Asn Asp 
     290                295                300
Leu Arg Ser Val Thr Leu Leu Glu Ala Lys Gly Lys Val Lys Asp Ile 
 305                310                315                320
Ala Ile Ser Arg Glu Arg Ile Thr Leu Lys Asp Val Leu Gln Glu Gly 
                 325                330                335
Thr Phe Gly Arg Ile Phe His Gly Ile Leu Ile Asp Glu Lys Asp Pro 
             340                345                350
Asn Lys Glu Lys Gln Ala Phe Val Lys Thr Val Lys Asp Gln Ala Ser 
         355                360                365
Glu Ile Gln Val Thr Met Met Leu Thr Glu Ser Cys Lys Leu Arg Gly 
     370                375                380
Leu His His Arg Asn Leu Leu Pro Ile Thr His Val Cys Ile Glu Glu 
 385                390                395                400
Gly Glu Lys Pro Met Val Ile Leu Pro Tyr Met Asn Trp Gly Asn Leu 
                 405                410                415
Lys Leu Phe Leu Arg Gln Cys Lys Leu Val Glu Ala Asn Asn Pro Gln 
             420                425                430
Ala Ile Ser Gln Gln Asp Leu Val His Met Ala Ile Gln Ile Ala Cys 
         435                440                445
Gly Met Ser Tyr Leu Ala Arg Arg Glu Val Ile His Lys Asp Leu Ala 
     450                455                460
Ala Arg Asn Cys Val Ile Asp Asp Thr Leu Gln Val Lys Ile Thr Asp 
 465                470                475                480
Asn Ala Leu Ser Arg Asp Leu Phe Pro Met Asp Tyr His Cys Leu Gly 
                 485                490                495
Asp Asn Glu Asn Arg Pro Val Arg Trp Met Ala Leu Glu Ser Leu Val 
             500                505                510
Asn Asn Glu Phe Ser Ser Ala Ser Asp Val Trp Ala Phe Gly Val Thr 
         515                520                525
Leu Trp Glu Leu Met Thr Leu Gly Gln Thr Pro Tyr Val Asp Ile Asp 
     530                535                540
Pro Phe Glu Met Ala Ala Tyr Leu Lys Asp Gly Tyr Arg Ile Ala Gln 
 545                550                555                560
Pro Ile Asn Cys Pro Asp Glu Leu Phe Ala Val Met Ala Cys Cys Trp 
                 565                570                575
Ala Leu Asp Pro Glu Glu Arg Pro Lys Phe Gln Gln Leu Val Gln Cys 
             580                585                590
Leu Thr Glu Phe His Ala Ala Leu Gly Ala Tyr Val 
         595                600



<210> 5703
<211> 584
<212> DNA
<213> Rattus norvegicus
<308> AA892270
<400> 5703

aaacaagaa  ttatttgta  aaagcatta  aatcttctc  acagtctcc  gtcactttc  60
acaaactct  ccctgtatt  ccctgacta  ttaacagtg  tcaactata  tacattacc  120
gtcagcctc  tgtgcacaa  taagacaga  aaagtgctt  gagcactaa  tggggaaaa  180
aaaggccaa  aggcacgct  aaagctgca  cagtggtgc  acattcctg  gcaccgttt  240
tctcacctt  agggtcaga  gtgcttctc  agtctcttt  aaagacagg  gatgaggaa  300
caatctgag  accttgcac  ttatcagag  ccctagact  gaagatgaa  tgaataaga  360
gaggagaaa  cagggctgg  aagcagagg  gggagagat  gagacagaa  ggctgtgcc  420
ggaggagat  aagtctctg  aacttgcta  gagttcagg  gataaaaag  agcagccat  480
atctgagag  tggactaga  aagagacaa  ctgggattt  ataccttcc  agaggtggc  540
ctaggttct  cagtggcag  cactgagtt  ccgccaagt  taag  584



<210> 5704
<211> 584
<212> DNA
<213> Rattus norvegicus
<308> AA892270
<400> 5704

aaacaagaa  ttatttgta  aaagcatta  aatcttctc  acagtctcc  gtcactttc  60
acaaactct  ccctgtatt  ccctgacta  ttaacagtg  tcaactata  tacattacc  120
gtcagcctc  tgtgcacaa  taagacaga  aaagtgctt  gagcactaa  tggggaaaa  180
aaaggccaa  aggcacgct  aaagctgca  cagtggtgc  acattcctg  gcaccgttt  240
tctcacctt  agggtcaga  gtgcttctc  agtctcttt  aaagacagg  gatgaggaa  300
caatctgag  accttgcac  ttatcagag  ccctagact  gaagatgaa  tgaataaga  360
gaggagaaa  cagggctgg  aagcagagg  gggagagat  gagacagaa  ggctgtgcc  420
ggaggagat  aagtctctg  aacttgcta  gagttcagg  gataaaaag  agcagccat  480
atctgagag  tggactaga  aagagacaa  ctgggattt  ataccttcc  agaggtggc  540
ctaggttct  cagtggcag  cactgagtt  ccgccaagt  taag  584



<210> 5705
<211> 665
<212> DNA
<213> Rattus norvegicus
<308> AA892271
<400> 5705

agagtagat  aaagtactt  tattataaa  ttcaggatc  aagaagtaa  gttacatga  60
taagataaa  ctgagatga  ttcttatca  gcatgtgtg  cttgcaggg  ggcactgtg  120
cctccggca  gagaaagac  gtcccacct  ccttgaggg  tggggtcag  caggtgata  180
gcgactgcc  agtcccact  gctacagtg  gtgcctggg  ccctctgcg  ctgtggccc  240
ggtgctgcg  tgaactcag  ccaagaagt  tcttcaatg  taaagatta  accagaacc  300
cagcatcag  cttggtctt  aatttaagt  atacctaat  ataaatgat  aagctttat  360
atttatttc  gtgatttac  ctgagtaag  attatgacc  aattggttc  gtaagccaa  420
ggatgacag  ttcctacat  cagagaccc  cagagaagc  gatgacagt  caacaccca  480
gaacactac  ccagggttc  agatggcat  tatgccatc  gaggtgtcc  ttatcagac  540
tatcagaag  acgtgggat  gctggctat  cctgtaaga  ctcaaatag  cctcgccgg  600
tcacgctga  caccttcct  cttctaaga  caatgactg  agcctgtac  ctgccctgg  660
aatca  665



<210> 5706
<211> 529
<212> DNA
<213> Rattus norvegicus
<308> AA892273
<400> 5706

caaacattc  agaacagtt  atttctatg  gatgtaaac  cttccataa  gtaagacaa  60
aggcaacag  cccccgctc  gaggtacgc  gaccaaaag  accattcag  accatctta  120
aaacctctt  agaaatctt  ctaaaaaca  aggcactca  atacaagaa  gttcatagc  180
gcattgtgt  taagaacag  aacctgcaa  cagcccaaa  gttattcag  aggtgagtg  240
ctacctaag  tgttttgtc  gcttggtgg  gtattatac  gatggaaat  aacaagtta  300
agcaatcac  acgtacagg  gtcttacaa  caatggtta  gtgcaaaaa  gcaaacctc  360
aggaacaga  tacaacatt  ttgtaaagc  aaaagtaca  gcaatacan  ataatacat  420
cctaaagga  atatacaca  atgggcaat  ttattataa  aagtgatta  tgagcataa  480
attaaagac  gtggctacc  ctaggaaga  gctgggcaa  gggacaaaa  529



<210> 5707
<211> 572
<212> DNA
<213> Rattus norvegicus
<308> AA892284
<400> 5707

ggaaatttt  gtcaaaaat  aagcaacta  gaaaaatca  ggcaattta  tgtaaatga  60
agttgattt  aataaggca  attcaacat  atcaatatg  aaacaaatg  aaaaaagca  120
ttatggtga  ttgaaaagt  tgacaagcc  ttaaatttg  gaatacatc  aggcaggat  180
cttggggct  agaaatcct  gatagagaa  gtaagcgtg  tgctggaca  cgttttgct  240
catttctct  gtgttcaca  ctgtctgcc  tacccagca  ctgtgctca  agtgctccg  300
ccttaaacg  gaatgtgaa  caaaggcct  gagacaaag  tgtcccctc  atcagccag  360
actgttagg  tgggccgac  ggaagggca  tgatcctca  taccctccc  caagcctcc  420
aacttccag  taaaatttg  tcaaattag  tcagggata  gaactctct  gaacttctc  480
gatgatctc  gagaactac  taaaagaac  ctaagaacc  taaatttta  ctgaaaggg  540
aagcgagac  caagtctaa  gacagtttc  at  572



<210> 5708
<211> 640
<212> DNA
<213> Rattus norvegicus
<308> AA892297
<400> 5708

ccaagtaca  ttttttaat  aagataatt  caaaagatg  aaaaatcag  tcagaaagg  60
caattgttt  tttaataga  ccgtttttt  ttttgacat  ataacacat  aatttaaat  120
caatcacat  aagcatggt  gaaaaaaat  tgcttcata  ttagaaaaa  tcacaataa  180
acttgccaa  gaaaaccaa  aacaagcca  tttgaaaat  aatacagtc  atgccaaaa  240
agtataaaa  gaagccaaa  ttcctcaaa  agcgaaggt  tcttatccc  gaatcgtct  300
acttttcga  gttcctaag  ttggggagt  aaattcaag  gttgttgag  tgttctgat  360
tggctcctt  ggtgtctgt  ttctcacca  tattgtcct  ggatttgtc  tcttcctta  420
catctgtcc  cttgtcctc  gcctccttc  tgtcttcct  aatcctggc  tttttggct  480
ccttcttat  atcagcgac  ttcctacga  ctccttcac  ttcatcctc  gaatctgag  540
actcttcat  acaagctat  cgcttgtct  atgctcgaa  agaaattct  ttgtcaggg  600
cttctccat  ctcatcacc  ctgtcttca  gaacagcatc  640



<210> 5709
<211> 174
<212> PRT
<213> Rattus norvegicus
<308> AAK11183
<400> 5709

Tyr Glu Thr Ala Val Ala Leu Asp Cys Glu Ile Pro Asn Glu Leu Pro 
  1               5                  10                  15
Tyr Asn Asp Tyr Phe Glu Tyr Phe Gly Pro Asp Phe Lys Leu His Ile 
             20                  25                  30
Ser Pro Ser Asn Met Thr Asn Gln Asn Thr Pro Glu Tyr Met Glu Lys 
         35                  40                  45
Ile Lys Gln Arg Leu Phe Glu Asn Leu Arg Met Leu Pro His Ala Pro 
     50                  55                  60
Gly Val Gln Met Gln Ala Ile Pro Glu Asp Ala Val His Glu Asp Ser 
 65                  70                  75                  80
Gly Asp Glu Asp Gly Glu Asp Pro Asp Lys Arg Ile Ser Ile Arg Ala 
                 85                  90                  95
Ser Asp Lys Arg Ile Ala Cys Asp Glu Glu Phe Ser Asp Ser Glu Asp 
             100                105                110
Glu Gly Glu Gly Gly Arg Arg Asn Val Ala Asp His Lys Lys Gly Ala 
         115                120                125
Lys Lys Ala Arg Ile Glu Glu Asp Lys Lys Glu Ala Glu Asp Lys Lys 
     130                135                140
Thr Asp Val Lys Glu Glu Asp Lys Ser Lys Asp Asn Ser Gly Glu Lys 
 145                150                155                160
Thr Asp Thr Lys Gly Ala Lys Ser Glu Gln Leu Asn Asn Pro 
                 165                170



<210> 5710
<211> 1985
<212> DNA
<213> Homo sapiens
<308> U31814
<400> 5710

cgccgagct  tcggcacct  tgccgggtg  taccgagcc  tcccggcgc  ccctcctct  60
ctcccaccg  cctgccctt  cccgcggga  tatcgcccc  acgtttccc  cagcccttt  120
ctctcccgg  cgagccgcg  cggcagcag  agcagcagc  gcagcagga  gaggagccc  180
gtggcggcg  tggccgggg  gcccatggc  tacagtcaa  gaggcggca  aaaaaaagt  240
tgctactac  acgacggtg  tattggaaa  tattattat  gacagggtc  tcccatgaa  300
cctcataga  tccgcatga  ccataactt  ctgttaaat  atggcttat  cagaaaaat  360
gaaatatat  ggccccata  agccactgc  gaagaaatg  caaaatatc  cagtgatga  420
tatatcaaa  ttctacggt  aataagacc  gataacatg  ctgagtata  taagcagat  480
catatattt  atgttggag  agattgtcc  gcgtttgat  gactctttg  gttttgtca  540
ctctcaact  gcggttcag  tgctggagc  gtgaagtta  accgacaac  gactgatat  600
gctgttaat  gggctggag  attacatca  gctaagaaa  acgaagcat  aggattctg  660
tacgttaat  atattgtgc  tgccatcct  gaattacta  agtatcatc  gagagtctt  720
tatattgat  tagatattc  tcatggtga  ggtgttgaa  aagcttttt  tacaacaga  780
cgtgtaatg  cggtatcat  ccataaata  ggggaatac  ttcctggca  aggagactt  840
agggatatt  gtgctggaa  aggcaaata  tatgctgtc  attttccaa  gtgtgatgg  900
atagatgat  agtcatatg  gcagatatt  aagcctatt  tctcaaagg  gatggagat  960
tatcaacct  gtgctgtgg  attacagtg  ggtgcagac  cattatctg  tgatagact  1020
ggttgtttc  atctaacag  caaaggtca  gctaaatgt  tagaagttg  aaaaacttt  1080
aacttacca  tactgatgc  tggaggagg  ggctacaca  tccgtaatg  tgctcgatg  1140
tggacatat  agactgcag  tgcccttga  tgtgagatt  ccaatgagt  gccatataa  1200
gattacttt  agtattttg  accagactt  aaactgcat  ttagtcctt  aaacatgac  1260
aaccagaac  ctccagaat  tatggaaaa  ataaaacag  gtttgtttg  aaatttgcg  1320
atgttacct  atgcacctg  tgtccagat  caagctatt  cagaagatg  tgttcatga  1380
gacagtgga  atgaagatg  agaagatcc  gacaagaga  tttctattc  agcatcaga  1440
aagcggata  cttgtgatg  agaattctc  gattctgag  atgaaggag  aggaggtcg  1500
agaaatgtg  ctgatcata  gaaaggagc  aagaaagct  gaattgaag  agataagaa  1560
gaaacagag  acaaaaaaa  agacgttaa  gaagaagat  aatccaagg  caacagtgg  1620
gaaaaaaca  ataccaaag  aaccaaatc  gaacagctc  gcaacccct  aatttgaca  1680
tctcaccaa  ttcagaaaa  cattaaaaa  aaaatattg  aaggaaaat  ttttctttt  1740
gaagacttc  ggcttcatt  tatactact  tggcatgga  tgtatttat  ttcaaatgg  1800
actttttcg  ttttgtttt  ctgggcaag  tttattgtg  gattttcta  ttatgaagc  1860
aaatttctt  tctccacca  gctttatgt  atagtattt  aaattgatg  gagttatta  1920
gtcaaaaaa  ctgatctat  aaagaagta  ttggccttt  tgagctgaa  aaaaaaaaa  1980
aaaag  1985



<210> 5711
<211> 488
<212> PRT
<213> Homo sapiens
<308> Q92769
<400> 5711

Met Ala Tyr Ser Gln Gly Gly Gly Lys Lys Lys Val Cys Tyr Tyr Tyr 
  1               5                  10                  15
Asp Gly Asp Ile Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro Met Lys 
             20                  25                  30
Pro His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr Gly Leu 
         35                  40                  45
Tyr Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Thr Ala Glu Glu 
     50                  55                  60
Met Thr Lys Tyr His Ser Asp Glu Tyr Ile Lys Phe Leu Arg Ser Ile 
 65                  70                  75                  80
Arg Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met His Ile Phe Asn 
                 85                  90                  95
Val Gly Glu Asp Cys Pro Ala Phe Asp Gly Leu Phe Glu Phe Cys Gln 
             100                105                110
Leu Ser Thr Gly Gly Ser Val Ala Gly Ala Val Lys Leu Asn Arg Gln 
         115                120                125
Gln Thr Asp Met Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys 
     130                135                140
Lys Tyr Glu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala 
 145                150                155                160
Ile Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile 
                 165                170                175
Asp Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp 
             180                185                190
Arg Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly 
         195                200                205
Thr Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala 
     210                215                220
Val Asn Phe Pro Met Cys Asp Gly Ile Asp Asp Glu Ser Tyr Gly Gln 
 225                230                235                240
Ile Phe Lys Pro Ile Ile Ser Lys Val Met Glu Met Tyr Gln Pro Ser 
                 245                250                255
Ala Val Val Leu Gln Cys Gly Ala Asp Ser Leu Ser Gly Asp Arg Leu 
             260                265                270
Gly Cys Phe Asn Leu Thr Val Lys Gly His Ala Lys Cys Val Glu Val 
         275                280                285
Val Lys Thr Phe Asn Leu Pro Leu Leu Met Leu Gly Gly Gly Gly Tyr 
     290                295                300
Thr Ile Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala 
 305                310                315                320
Leu Asp Cys Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu 
                 325                330                335
Tyr Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr 
             340                345                350
Asn Gln Asn Thr Pro Glu Tyr Met Glu Lys Ile Lys Gln Arg Leu Phe 
         355                360                365
Glu Asn Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala 
     370                375                380
Ile Pro Glu Asp Ala Val His Glu Asp Ser Gly Asp Glu Asp Gly Glu 
 385                390                395                400
Asp Pro Asp Lys Arg Ile Ser Ile Arg Ala Ser Asp Lys Arg Ile Ala 
                 405                410                415
Cys Asp Glu Glu Phe Ser Asp Ser Glu Asp Glu Gly Glu Gly Gly Arg 
             420                425                430
Arg Asn Val Ala Asp His Lys Lys Gly Ala Lys Lys Ala Arg Ile Glu 
         435                440                445
Glu Asp Lys Lys Glu Thr Glu Asp Lys Lys Thr Asp Val Lys Glu Glu 
     450                455                460
Asp Lys Ser Lys Asp Asn Ser Gly Glu Lys Thr Asp Thr Lys Gly Thr 
 465                470                475                480
Lys Ser Glu Gln Leu Ser Asn Pro 
                 485



<210> 5712
<211> 601
<212> DNA
<213> Rattus norvegicus
<308> AA892298
<400> 5712

cagtcttag  ggcacaggc  ttaatccca  cacttggga  gaggaggca  aggcaggca  60
atatatgtg  gttcaagcc  atcctgatt  atgttgtga  ttccaggtc  gctggggct  120
catagtgag  ccctgtttt  cgaacactg  atatttcat  tccaagtgt  gctgcttgc  180
ataggtgat  aagaactga  atccgttgg  gtttgggcc  ttattagcc  tagatacaa  240
acctcgaac  ttgtgcttc  gatattcac  gtattcatc  tcaaacttc  tgccccaga  300
actgctgcc  cctcttcca  tacctgttg  atctcctgt  tgaaccatg  agcccttga  360
atttctatg  aacacacag  cattgtagt  attactggc  cacagagcc  agaaattct  420
acaggtttt  ggtgttctc  cacagaaga  ttctatctt  atatctccc  catctgtat  480
cagtgtcac  gacattctc  ttcttgatg  ttctaggga  cactattta  tttttcaaa  540
ctcctcgct  agcaccgct  ctgcggtaa  aaaaatgtc  cattcacag  tgccggcat  600
c  601



<210> 5713
<211> 163
<212> PRT
<213> Rattus norvegicus
<308> CSRTA
<400> 5713

Val Asn Pro Thr Val Phe Phe Asp Ile Thr Ala Asp Gly Glu Pro Leu 
  1               5                  10                  15
Gly Arg Val Cys Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala 
             20                  25                  30
Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys 
         35                  40                  45
Gly Ser Ser Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly 
     50                  55                  60
Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu 
 65                  70                  75                  80
Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile 
                 85                  90                  95
Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe 
             100                105                110
Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val Phe 
         115                120                125
Gly Lys Val Lys Glu Gly Met Ser Ile Val Glu Ala Met Glu Arg Phe 
     130                135                140
Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ser Asp Cys 
 145                150                155                160
Gly Gln Leu 
                 165



<210> 5714
<211> 1137
<212> DNA
<213> Homo sapiens
<308> AF251049
<400> 5714

ggggaggaa  gaggtgagg  ggtaagggg  gttctctct  ttgggtccc  cgcccaact  60
ccgctggcc  aaagaaact  taattttga  ccaacagac  tctgctggc  tctgcgatt  120
catttttcc  gttttaaca  cggctgtgc  agacgaagt  gtgaagccc  aagacttat  180
tttgagctc  ctgtaagac  gagaaatca  gtagtcctt  ctgaaacca  taagaggaa  240
aatgtctgt  acactgcat  cagatgtag  tgatattaa  attgaagtc  tctgtgaga  300
gacacccaa  acatgtgag  tggagtctc  ctgtgtccc  caggctgga  tacaatggc  360
cgatctcgg  tcactgcaa  ctccgcctc  tgggttcaa  caagtcttc  gcctcagcc  420
cccgagaac  ggaagagga  gcaacagta  ttggggcaa  aagtttgag  atgaataca  480
tgaatatct  aagcacaat  ttagaggtg  tgtatctat  gctaataat  gcccgaaca  540
caatggatc  cagttcttc  tcacctatg  caaacagcc  catttggac  tgaaataca  600
cgtatttgg  aaggtaata  atggtctgg  aactctaga  gagttggag  agttgccag  660
aaatgagaa  acataccga  ctcttaatg  tgtacacat  aaggacata  ctattcatg  720
caacccatt  gctcagtag  tatgataga  ctggacaaa  aacttgaca  attgctgga  780
cacacttat  gtggtttac  cggttttaa  tatgtcaga  attgcatca  ccttctgct  840
gtttacaac  atgatcttc  atgaaatgg  ggtaccaag  ggcgcccaa  agcttttat  900
cccattctt  gagcatatt  tttattata  tgattatcc  acatatttc  ttaatttta  960
tacaaaaaa  acatcattt  atttttgtt  catatgaac  ttcattttt  aatgctcag  1020
ctcaagtgc  ggcattttt  agtggcctg  ttacatatt  ctcccacag  aagtccgta  1080
cctggaagt  ttattttat  ataaaattt  aaaagtttt  aggaaaaaa  aaaaaaa  1137



<210> 5715
<211> 48
<212> PRT
<213> Homo sapiens
<308> S64705
<400> 5715

Cys Leu Val Cys Gly Asp Arg Ala Ser Gly Tyr His Tyr Asn Ala Leu 
  1               5                  10                  15
Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Val Thr Lys Ser 
             20                  25                  30
Ala Val Tyr Cys Cys Lys Phe Gly Arg Ala Cys Glu Met Asp Met Tyr 
         35                  40                  45



<210> 5716
<211> 665
<212> DNA
<213> Rattus norvegicus
<308> AA892299
<400> 5716

ttgcggccg  aaaactttt  tttttattt  ttttttttt  tttttaaag  caaaaaagt  60
aactttatt  actgttgat  ttaccatga  acacctata  gaaataatt  caaaataac  120
ccgcttttc  tttcttttt  ttaacatac  ttcagttat  atcccgaca  gacgatcct  180
tcacagaaa  gactgtttg  agcttactg  gatacaaag  tcaaatgca  atgcagaag  240
ggcagggag  cacatcccc  agcaacggg  gtgctagcg  gcgagcgtg  gcgacagct  300
tctacttcc  tctttttgt  tttgatgac  atttcccaa  acaaaaatg  caggtcttc  360
gagtggatc  ccacctatg  ctgtgtgac  ctaccgtgg  tcagaaact  gaaactgtt  420
cctggctgt  tttgtcttt  aaaatctgt  agactgttc  tgccggcct  gaggagggc  480
gctgaggag  ggcagcctg  gcagagccc  gaagcctgg  ttctggagc  gagaggaaa  540
ggtacaacc  attcgatta  gcaacttca  cactttgca  ctgcaagag  cgctgaggg  600
tgcggggcg  acagctcca  aatcagagc  tgggagggc  cgcccctta  cagggtctg  660
gccct  665



<210> 5717
<211> 605
<212> DNA
<213> Rattus norvegicus
<308> AA892300
<400> 5717

acccacatc  gtccagttt  ttcttcata  aaatatttt  cagttttat  tttaaatca  60
ttacacata  gcatacaaa  aaaaataaa  ttcaggatg  aactttggg  ccatggcag  120
ttaaaaaaa  attctgatc  ttagctact  aagacaagg  aagaggctt  gcagtcatt  180
gtgggagtc  gcgcgtcgc  ccacacaga  aacagtgga  acgtctcca  ccactccct  240
agtatcact  catcttcac  ttgtagagg  aatgaatac  gggggaggg  attttcaat  300
atagcccct  taaatgttt  aagaaggct  atggtaaca  tgaaccctg  ggaatttgg  360
aagaatgca  cttctgaac  agtttgcta  aagagtttg  tcagttcct  cttccaagg  420
tcccaataa  aagagagga  tgcaggact  accacacca  gactgtccc  cctgactct  480
ggctcagtc  acaactgaa  atccctccc  cacaggcca  ggagcctgc  tgacaagcc  540
tggccctga  gacactaca  taaccacat  agcatcact  cttcagtgt  cacccacag  600
ggatc  605



<210> 5718
<211> 3048
<212> DNA
<213> Homo sapiens
<308> U19721
<400> 5718

agctggcgg  caccatggc  atgcgggag  tggtggagg  cgaatgcgg  ggtgccaac  60
cgctcatga  gctcgccgg  cacttcacc  aggacaagg  ccttcggca  gagggattg  120
ggcctggcc  ctggccccc  ggagcaccg  cctctgagg  agcctccaa  cctttggga  180
tagcttctg  agatgagtt  gtggctgaa  tcctgcagg  ccagaatgc  ccccttgtg  240
cccgtgccc  tcagacctt  aagatggat  acctcctgg  tgagatgca  cagattgag  300
agtcaaact  ccgccaggc  ccccagaga  cccctggtg  ggcagactt  gccttgtct  360
agaactggg  ccaggagtt  cttgcagct  gagatgctg  ggatgtaac  caggattat  420
atgagactg  ctggtccca  gaattcatc  ctgaagtta  agacccctt  tctgtgtcc  480
ctgcccgct  ggctgagga  tatttggag  aatcagagg  gaagctgtg  ctgggagaa  540
ctgagggaa  agccaccga  cgctggtat  atgaatatc  tcctgagga  gatctgcag  600
acacggcca  tgactttgt  gccaaagtg  atgacccca  attggctaa  tctgagggt  660
catcagatg  ctgggttga  cagttcaca  gaccagtaa  cacatctgc  cttgatatg  720
agtttgaac  agccaagtc  gctatagag  ctgatgtcg  tttctggga  aagttgcag  780
cagagttgg  ggagatggc  aaacgggat  ctgaggccc  cccctggct  tctgactat  840
atgacctta  gtcagctac  tatgataag  ggtaccagt  tgaggagga  aaccccttg  900
gtgatcacc  tcagccttt  gaagaaggg  tgcggcgcc  tcaggaggg  gacctgcca  960
atgctgtgc  gctttttga  gcagctgtg  agcaggatc  taagcacat  gaagcttgg  1020
agtatctgg  taccaccca  gcagagaat  aacaagaac  attagccat  agtgcattg  1080
ggaggtgtc  ggagctaaa  ccagataac  agacagcac  gatggcgct  gctgtgagc  1140
tcaccaacg  gtccctgca  cgacaggcc  gtgaaatcc  acgagactg  ctgcggtac  1200
caccagcct  tgcccatct  gtgacacct  ctgaagaag  ggctggtgg  gcaggactg  1260
gccccagca  gcgtatcct  ggatctctc  tgtctgact  cctgtttct  gaagtgaaa  1320
agctcttcc  ggcagctgt  cggctggac  ctacctcca  tgaccctga  gtgcagtgt  1380
gcttgggag  ccttttcaa  ctgagtggg  agtatgaca  ggccgtgga  tgcttcaca  1440
ctgccctca  cgttcgtcc  aatgactat  tgctgtgga  taagctagg  gccaccctg  1500
ccaatggaa  ccagagtga  gaagcagta  ctgcgtacc  ccgggccct  gagctccag  1560
ctggctata  ccggtcccg  tataacctg  gcatcagct  catcaacct  ggggctcac  1620
gggaggctg  ggagcactt  ctggaggcc  tgaacatgc  gaggaaaag  cggggcccc  1680
ggggtgaag  aggtgccat  tcggagaac  tctggagca  cctgcgttt  gcattgtct  1740
tgttaggcc  gagcgatgc  tatggggca  ccgacgcgc  ggatctgtc  accctccta  1800
ctatgtttg  cctgcccca  tgacagtgg  acgggctgc  ctgtgagtg  ccacctgga  1860
ggatcccgc  tttggatgt  attccctct  cccaaatgg  cctaccaag  ggcgggctt  1920
atgaccata  gcggtacgg  ctttcagga  ctgcctcaa  gtaggggtg  gtagtctgt  1980
ttctagttc  tacataatt  taggaaaat  agctgtgtc  tctctgagt  ccttggtaa  2040
tcaagggct  tacatccag  tacagatct  tctgctcat  atgcccttt  ttggtgctg  2100
tttttgggt  ggaccccac  atttagggt  actgttatc  tcagctgcc  tttctgata  2160
gtctaccac  tctgtaatg  catgtcctt  cccccactt  tactgggaa  tgatagtcc  2220
gcttccttg  gcagtgtaa  taggaggtt  atctcctgt  cgcctctaa  gtctgtctg  2280
atgggatgt  ttaggagtt  gcctgttgg  ttgaattgt  gatttggct  agcagagct  2340
agttttggt  ggagtgctc  tggttctgt  attcttgga  ctctcctgg  tgagctctg  2400
ttccctgtg  gcacgatgc  gatgcaata  tcctgtgtc  tcactgcag  ggtcctcag  2460
agctgccag  gccaattgc  acagagtgt  tgggtgtgt  gcataggag  aaggtttgc  2520
tgtgaaatg  ggctgggtg  gagcgggga  ggactagat  agaagagat  aagggctct  2580
ttcaggaac  ttggtggga  gacagagca  gtgggaagg  ggtatggtg  gtgcggcaa  2640
ccctcatcc  cttagaagc  cctgtgaat  ggaattgag  caactgtta  agaaaattg  2700
ttcagaaag  gcaatcttg  cagatttct  gcaaatagg  tcagtgtta  cataagcct  2760
tgctgtact  cttgaaatg  ttctagggg  gagcattgg  aaatcccct  cccccatct  2820
gatcgaagg  agatgaggg  gcagcttgg  ttcttctca  ttgtcccct  catggggag  2880
tacactaac  cccagaaat  actgctaag  ctcttgcct  gtctttagt  gctaatgat  2940
agagagatt  tttttttaa  ctaccatgg  cccaggatt  catcctgaa  tttattttt  3000
tttgtatga  tatgtgtaa  tgatttaaa  ataaaactg  aaaatatt  3048



<210> 5719
<211> 602
<212> PRT
<213> Homo sapiens
<308> P50542
<400> 5719

Met Ala Met Arg Glu Leu Val Glu Ala Glu Cys Gly Gly Ala Asn Pro 
  1               5                  10                  15
Leu Met Lys Leu Ala Gly His Phe Thr Gln Asp Lys Ala Leu Arg Gln 
             20                  25                  30
Glu Gly Leu Arg Pro Gly Pro Trp Pro Pro Gly Ala Pro Ala Ser Glu 
         35                  40                  45
Ala Ala Ser Lys Pro Leu Gly Val Ala Ser Glu Asp Glu Leu Val Ala 
     50                  55                  60
Glu Phe Leu Gln Asp Gln Asn Ala Pro Leu Val Ser Arg Ala Pro Gln 
 65                  70                  75                  80
Thr Phe Lys Met Asp Asp Leu Leu Ala Glu Met Gln Gln Ile Glu Gln 
                 85                  90                  95
Ser Asn Phe Arg Gln Ala Pro Gln Arg Ala Pro Gly Val Ala Asp Leu 
             100                105                110
Ala Leu Ser Glu Asn Trp Ala Gln Glu Phe Leu Ala Ala Gly Asp Ala 
         115                120                125
Val Asp Val Thr Gln Asp Tyr Asn Glu Thr Asp Trp Ser Gln Glu Phe 
     130                135                140
Ile Ser Glu Val Thr Asp Pro Leu Ser Val Ser Pro Ala Arg Trp Ala 
 145                150                155                160
Glu Glu Tyr Leu Glu Gln Ser Glu Glu Lys Leu Trp Leu Gly Glu Pro 
                 165                170                175
Glu Gly Thr Ala Thr Asp Arg Trp Tyr Asp Glu Tyr His Pro Glu Glu 
             180                185                190
Asp Leu Gln His Thr Ala Ser Asp Phe Val Ala Lys Val Asp Asp Pro 
         195                200                205
Lys Leu Ala Asn Ser Glu Gly Thr Ser Asp Ala Trp Val Asp Gln Phe 
     210                215                220
Thr Arg Pro Val Asn Thr Ser Ala Leu Asp Met Glu Phe Glu Arg Ala 
 225                230                235                240
Lys Ser Ala Ile Glu Ser Asp Val Asp Phe Trp Asp Lys Leu Gln Ala 
                 245                250                255
Glu Leu Glu Glu Met Ala Lys Arg Asp Ala Glu Ala His Pro Trp Leu 
             260                265                270
Ser Asp Tyr Asp Asp Leu Thr Ser Ala Thr Tyr Asp Lys Gly Tyr Gln 
         275                280                285
Phe Glu Glu Glu Asn Pro Leu Arg Asp His Pro Gln Pro Phe Glu Glu 
     290                295                300
Gly Leu Arg Arg Leu Gln Glu Gly Asp Leu Pro Asn Ala Val Leu Leu 
 305                310                315                320
Phe Glu Ala Ala Val Gln Gln Asp Pro Lys His Met Glu Ala Trp Gln 
                 325                330                335
Tyr Leu Gly Thr Thr Gln Ala Glu Asn Glu Gln Glu Leu Leu Ala Ile 
             340                345                350
Ser Ala Leu Arg Arg Cys Leu Glu Leu Lys Pro Asp Asn Gln Thr Ala 
         355                360                365
Leu Met Ala Leu Ala Val Ser Phe Thr Asn Glu Ser Leu Gln Arg Gln 
     370                375                380
Ala Cys Glu Thr Leu Arg Asp Trp Leu Arg Tyr Thr Pro Ala Tyr Ala 
 385                390                395                400
His Leu Val Thr Pro Ala Glu Glu Gly Ala Gly Gly Ala Gly Leu Gly 
                 405                410                415
Pro Ser Lys Arg Ile Leu Gly Ser Leu Leu Ser Asp Ser Leu Phe Leu 
             420                425                430
Glu Val Lys Glu Leu Phe Leu Ala Ala Val Arg Leu Asp Pro Thr Ser 
         435                440                445
Ile Asp Pro Asp Val Gln Cys Gly Leu Gly Val Leu Phe Asn Leu Ser 
     450                455                460
Gly Glu Tyr Asp Lys Ala Val Asp Cys Phe Thr Ala Ala Leu Ser Val 
 465                470                475                480
Arg Pro Asn Asp Tyr Leu Leu Trp Asn Lys Leu Gly Ala Thr Leu Ala 
                 485                490                495
Asn Gly Asn Gln Ser Glu Glu Ala Val Ala Ala Tyr Arg Arg Ala Leu 
             500                505                510
Glu Leu Gln Pro Gly Tyr Ile Arg Ser Arg Tyr Asn Leu Gly Ile Ser 
         515                520                525
Cys Ile Asn Leu Gly Ala His Arg Glu Ala Val Glu His Phe Leu Glu 
     530                535                540
Ala Leu Asn Met Gln Arg Lys Ser Arg Gly Pro Arg Gly Glu Gly Gly 
 545                550                555                560
Ala Met Ser Glu Asn Ile Trp Ser Thr Leu Arg Leu Ala Leu Ser Met 
                 565                570                575
Leu Gly Gln Ser Asp Ala Tyr Gly Ala Ala Asp Ala Arg Asp Leu Ser 
             580                585                590
Thr Leu Leu Thr Met Phe Gly Leu Pro Gln 
         595                600



<210> 5720
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AA892318
<400> 5720

gaacaagat  atttaatag  gaccctctg  tgtccactt  ggtgcctag  ccacccact  60
cacccaaga  gatgctggg  cgtaggaaa  gccgctgga  atcagtctc  aaactacca  120
cagcagttc  cagagctgg  atggcagtg  cctccctca  ggaagcagg  ctgctcgca  180
ctggaaggc  aggccgtcc  ctcgggtgg  ttgctgagg  aagaaacag  ttggaagca  240
gagaaacta  gtgtagaca  aatgagggc  gagcatagg  agagtggta  caccaacct  300
gttgatctc  ctgtgtcgt  ctttggtta  gatctcctc  aaaacctca  cgtctccct  360
gatgagcct  gtacggccg  tctctgggt  caccacctt  cgaataacg  tctgtcgag  420
gtcccactc  tcctttgtc  tgggcttca  ggcctggat  cgagacttc  gctcgtctg  480
caggactgg  ccatcattg  cctccccag  tgatctgtg  cactgatcc  gagaggggc  540
g  541



<210> 5721
<211> 229
<212> PRT
<213> Rattus norvegicus
<308> BAA94743
<400> 5721

Met Ala His Val Gly Ser Arg Lys Arg Ser Arg Ser Arg Ser Arg Ser 
  1               5                  10                  15
Arg Ser Gly Arg Arg Gly Ser Glu Lys Arg Ser Lys Arg Ser Ser Lys 
             20                  25                  30
Asp Ala Ser Arg Asn Cys Ser Ala Ser Arg Ser Gln Gly His Lys Ala 
         35                  40                  45
Gly Ser Ala Ser Gly Val Glu Glu Arg Ser Lys His Lys Ala Gln Arg 
     50                  55                  60
Thr Ser Arg Ser Ser Ser Thr Ser Ser Ser Ser Ser Ser Ser Ser Ser 
 65                  70                  75                  80
Ala Ser Ser Ser Ser Ser Ser Asp Gly Arg Lys Lys Arg Ala Lys His 
                 85                  90                  95
Lys Glu Lys Lys Arg Lys Lys Lys Lys Lys Lys Arg Lys Lys Lys Leu 
             100                105                110
Lys Lys Arg Val Lys Glu Lys Ala Val Ala Val His Gln Ala Glu Ala 
         115                120                125
Leu Pro Gly Pro Ser Leu Asp Gln Trp His Arg Ser Ala Gly Glu Asp 
     130                135                140
Asn Asp Gly Pro Val Leu Thr Asp Glu Gln Lys Ser Arg Ile Gln Ala 
 145                150                155                160
Met Lys Pro Met Thr Lys Glu Glu Trp Asp Ala Arg Gln Ser Val Ile 
                 165                170                175
Arg Lys Val Val Asp Pro Glu Thr Gly Arg Thr Arg Leu Ile Lys Gly 
             180                185                190
Asp Gly Glu Val Leu Glu Glu Ile Val Thr Lys Glu Arg His Arg Glu 
         195                200                205
Ile Asn Lys Gln Ala Thr Arg Gly Asp Gly Leu Ala Phe Gln Met Arg 
     210                215                220
Thr Gly Leu Leu Pro 
 225



<210> 5722
<211> 952
<212> DNA
<213> Homo sapiens
<308> AB035384
<400> 5722

gtcctctcg  gaaggcgcg  ggcgggctg  ccggcccgc  gggcggtcg  gcccgcggc  60
ccatggctc  cgtcggctc  cgcaagcgc  cgaggagtc  cagccggtc  cggggacgg  120
ggtcggaaa  gagaaagaa  aagagcagg  aagacacct  gaggaactg  tcggcctcc  180
catcccaag  gagaagcaa  cagaaggcc  ggaggagaa  aagatccag  tcctcctcc  240
cttcttcca  ttcttctag  tcctcttct  cctcctcgt  ctcctcctc  tcctccagt  300
atggccgga  gaagcgggg  aagtacaag  acaagagga  gaagaagaa  aagaagagg  360
agaagctga  gaagaaggg  aaggagaag  cggaagcac  gcaggtgga  gctctgccg  420
gcccctcgc  ggaccagtg  caccgatca  ctggggagg  agaggatgg  ccagtcctg  480
cggatgagc  gaagtcccg  atccaggcc  tgaagccca  gaccaagga  gagtgggat  540
cccggcaga  catcatccg  aaggtggtg  accctgaga  ggggcgcac  aggcttatt  600
agggagatg  cgaggtcct  gaggaaatc  taaccaaag  acgacacag  gagatcaac  660
agcaagcca  ccgagggga  tgcctggcc  tccagatgc  agctgggtt  cttccctga  720
ggcccccgc  ggccaaggc  tgtggacga  gctggcggc  cagcctggg  aggtttcag  780
gtgccagtg  gaagcctga  gggtgctgg  ggcctttcc  ccgtggatt  gtctctggc  840
cagcccagt  tcttctcag  ggcaggggg  ggaggttgg  gtcaccggc  tgcttggca  900
ccccatctg  aagagcagc  cttctcagc  attaaaggc  ccctggata  ac  952



<210> 5723
<211> 219
<212> PRT
<213> Homo sapiens
<308> AB035384
<400> 5723

Met Ala His Val Gly Ser Arg Lys Arg Ser Arg Ser Arg Ser Arg Ser 
  1               5                  10                  15
Arg Gly Arg Gly Ser Glu Lys Arg Lys Lys Lys Ser Arg Lys Asp Thr 
             20                  25                  30
Ser Arg Asn Cys Ser Ala Ser Thr Ser Gln Glu Arg Ser Lys Gln Lys 
         35                  40                  45
Ala Arg Arg Arg Thr Arg Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
     50                  55                  60
Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp 
 65                  70                  75                  80
Gly Arg Lys Lys Arg Gly Lys Tyr Lys Asp Lys Arg Arg Lys Lys Lys 
                 85                  90                  95
Lys Lys Arg Lys Lys Leu Lys Lys Lys Gly Lys Glu Lys Ala Glu Ala 
             100                105                110
Gln Gln Val Glu Ala Leu Pro Gly Pro Ser Leu Asp Gln Trp His Arg 
         115                120                125
Ser Ala Gly Glu Glu Glu Asp Gly Pro Val Leu Thr Asp Glu Gln Lys 
     130                135                140
Ser Arg Ile Gln Ala Met Lys Pro Met Thr Lys Glu Glu Trp Asp Ala 
 145                150                155                160
Arg Gln Ser Ile Ile Arg Lys Val Val Asp Pro Glu Thr Gly Arg Thr 
                 165                170                175
Arg Leu Ile Lys Gly Asp Gly Glu Val Leu Glu Glu Ile Val Thr Lys 
             180                185                190
Glu Arg His Arg Glu Ile Asn Lys Gln Ala Thr Arg Gly Asp Cys Leu 
         195                200                205
Ala Phe Gln Met Arg Ala Gly Leu Leu Pro Ter 
     210                215



<210> 5724
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AA892318
<400> 5724

gaacaagat  atttaatag  gaccctctg  tgtccactt  ggtgcctag  ccacccact  60
cacccaaga  gatgctggg  cgtaggaaa  gccgctgga  atcagtctc  aaactacca  120
cagcagttc  cagagctgg  atggcagtg  cctccctca  ggaagcagg  ctgctcgca  180
ctggaaggc  aggccgtcc  ctcgggtgg  ttgctgagg  aagaaacag  ttggaagca  240
gagaaacta  gtgtagaca  aatgagggc  gagcatagg  agagtggta  caccaacct  300
gttgatctc  ctgtgtcgt  ctttggtta  gatctcctc  aaaacctca  cgtctccct  360
gatgagcct  gtacggccg  tctctgggt  caccacctt  cgaataacg  tctgtcgag  420
gtcccactc  tcctttgtc  tgggcttca  ggcctggat  cgagacttc  gctcgtctg  480
caggactgg  ccatcattg  cctccccag  tgatctgtg  cactgatcc  gagaggggc  540
g  541



<210> 5725
<211> 229
<212> PRT
<213> Rattus norvegicus
<308> BAA94743
<400> 5725

Met Ala His Val Gly Ser Arg Lys Arg Ser Arg Ser Arg Ser Arg Ser 
  1               5                  10                  15
Arg Ser Gly Arg Arg Gly Ser Glu Lys Arg Ser Lys Arg Ser Ser Lys 
             20                  25                  30
Asp Ala Ser Arg Asn Cys Ser Ala Ser Arg Ser Gln Gly His Lys Ala 
         35                  40                  45
Gly Ser Ala Ser Gly Val Glu Glu Arg Ser Lys His Lys Ala Gln Arg 
     50                  55                  60
Thr Ser Arg Ser Ser Ser Thr Ser Ser Ser Ser Ser Ser Ser Ser Ser 
 65                  70                  75                  80
Ala Ser Ser Ser Ser Ser Ser Asp Gly Arg Lys Lys Arg Ala Lys His 
                 85                  90                  95
Lys Glu Lys Lys Arg Lys Lys Lys Lys Lys Lys Arg Lys Lys Lys Leu 
             100                105                110
Lys Lys Arg Val Lys Glu Lys Ala Val Ala Val His Gln Ala Glu Ala 
         115                120                125
Leu Pro Gly Pro Ser Leu Asp Gln Trp His Arg Ser Ala Gly Glu Asp 
     130                135                140
Asn Asp Gly Pro Val Leu Thr Asp Glu Gln Lys Ser Arg Ile Gln Ala 
 145                150                155                160
Met Lys Pro Met Thr Lys Glu Glu Trp Asp Ala Arg Gln Ser Val Ile 
                 165                170                175
Arg Lys Val Val Asp Pro Glu Thr Gly Arg Thr Arg Leu Ile Lys Gly 
             180                185                190
Asp Gly Glu Val Leu Glu Glu Ile Val Thr Lys Glu Arg His Arg Glu 
         195                200                205
Ile Asn Lys Gln Ala Thr Arg Gly Asp Gly Leu Ala Phe Gln Met Arg 
     210                215                220
Thr Gly Leu Leu Pro 
 225



<210> 5726
<211> 952
<212> DNA
<213> Homo sapiens
<308> AB035384
<400> 5726

gtcctctcg  gaaggcgcg  ggcgggctg  ccggcccgc  gggcggtcg  gcccgcggc  60
ccatggctc  cgtcggctc  cgcaagcgc  cgaggagtc  cagccggtc  cggggacgg  120
ggtcggaaa  gagaaagaa  aagagcagg  aagacacct  gaggaactg  tcggcctcc  180
catcccaag  gagaagcaa  cagaaggcc  ggaggagaa  aagatccag  tcctcctcc  240
cttcttcca  ttcttctag  tcctcttct  cctcctcgt  ctcctcctc  tcctccagt  300
atggccgga  gaagcgggg  aagtacaag  acaagagga  gaagaagaa  aagaagagg  360
agaagctga  gaagaaggg  aaggagaag  cggaagcac  gcaggtgga  gctctgccg  420
gcccctcgc  ggaccagtg  caccgatca  ctggggagg  agaggatgg  ccagtcctg  480
cggatgagc  gaagtcccg  atccaggcc  tgaagccca  gaccaagga  gagtgggat  540
cccggcaga  catcatccg  aaggtggtg  accctgaga  ggggcgcac  aggcttatt  600
agggagatg  cgaggtcct  gaggaaatc  taaccaaag  acgacacag  gagatcaac  660
agcaagcca  ccgagggga  tgcctggcc  tccagatgc  agctgggtt  cttccctga  720
ggcccccgc  ggccaaggc  tgtggacga  gctggcggc  cagcctggg  aggtttcag  780
gtgccagtg  gaagcctga  gggtgctgg  ggcctttcc  ccgtggatt  gtctctggc  840
cagcccagt  tcttctcag  ggcaggggg  ggaggttgg  gtcaccggc  tgcttggca  900
ccccatctg  aagagcagc  cttctcagc  attaaaggc  ccctggata  ac  952



<210> 5727
<211> 218
<212> PRT
<213> Homo sapiens
<308> NP_057722
<400> 5727

Met Ala His Val Gly Ser Arg Lys Arg Ser Arg Ser Arg Ser Arg Ser 
  1               5                  10                  15
Arg Gly Arg Gly Ser Glu Lys Arg Lys Lys Lys Ser Arg Lys Asp Thr 
             20                  25                  30
Ser Arg Asn Cys Ser Ala Ser Thr Ser Gln Glu Arg Ser Lys Gln Lys 
         35                  40                  45
Ala Arg Arg Arg Thr Arg Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
     50                  55                  60
Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp 
 65                  70                  75                  80
Gly Arg Lys Lys Arg Gly Lys Tyr Lys Asp Lys Arg Arg Lys Lys Lys 
                 85                  90                  95
Lys Lys Arg Lys Lys Leu Lys Lys Lys Gly Lys Glu Lys Ala Glu Ala 
             100                105                110
Gln Gln Val Glu Ala Leu Pro Gly Pro Ser Leu Asp Gln Trp His Arg 
         115                120                125
Ser Ala Gly Glu Glu Glu Asp Gly Pro Val Leu Thr Asp Glu Gln Lys 
     130                135                140
Ser Arg Ile Gln Ala Met Lys Pro Met Thr Lys Glu Glu Trp Asp Ala 
 145                150                155                160
Arg Gln Ser Ile Ile Arg Lys Val Val Asp Pro Glu Thr Gly Arg Thr 
                 165                170                175
Arg Leu Ile Lys Gly Asp Gly Glu Val Leu Glu Glu Ile Val Thr Lys 
             180                185                190
Glu Arg His Arg Glu Ile Asn Lys Gln Ala Thr Arg Gly Asp Cys Leu 
         195                200                205
Ala Phe Gln Met Arg Ala Gly Leu Leu Pro 
     210                215



<210> 5728
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AA892318
<400> 5728

gaacaagat  atttaatag  gaccctctg  tgtccactt  ggtgcctag  ccacccact  60
cacccaaga  gatgctggg  cgtaggaaa  gccgctgga  atcagtctc  aaactacca  120
cagcagttc  cagagctgg  atggcagtg  cctccctca  ggaagcagg  ctgctcgca  180
ctggaaggc  aggccgtcc  ctcgggtgg  ttgctgagg  aagaaacag  ttggaagca  240
gagaaacta  gtgtagaca  aatgagggc  gagcatagg  agagtggta  caccaacct  300
gttgatctc  ctgtgtcgt  ctttggtta  gatctcctc  aaaacctca  cgtctccct  360
gatgagcct  gtacggccg  tctctgggt  caccacctt  cgaataacg  tctgtcgag  420
gtcccactc  tcctttgtc  tgggcttca  ggcctggat  cgagacttc  gctcgtctg  480
caggactgg  ccatcattg  cctccccag  tgatctgtg  cactgatcc  gagaggggc  540
g  541



<210> 5729
<211> 229
<212> PRT
<213> Rattus norvegicus
<308> BAA94743
<400> 5729

Met Ala His Val Gly Ser Arg Lys Arg Ser Arg Ser Arg Ser Arg Ser 
  1               5                  10                  15
Arg Ser Gly Arg Arg Gly Ser Glu Lys Arg Ser Lys Arg Ser Ser Lys 
             20                  25                  30
Asp Ala Ser Arg Asn Cys Ser Ala Ser Arg Ser Gln Gly His Lys Ala 
         35                  40                  45
Gly Ser Ala Ser Gly Val Glu Glu Arg Ser Lys His Lys Ala Gln Arg 
     50                  55                  60
Thr Ser Arg Ser Ser Ser Thr Ser Ser Ser Ser Ser Ser Ser Ser Ser 
 65                  70                  75                  80
Ala Ser Ser Ser Ser Ser Ser Asp Gly Arg Lys Lys Arg Ala Lys His 
                 85                  90                  95
Lys Glu Lys Lys Arg Lys Lys Lys Lys Lys Lys Arg Lys Lys Lys Leu 
             100                105                110
Lys Lys Arg Val Lys Glu Lys Ala Val Ala Val His Gln Ala Glu Ala 
         115                120                125
Leu Pro Gly Pro Ser Leu Asp Gln Trp His Arg Ser Ala Gly Glu Asp 
     130                135                140
Asn Asp Gly Pro Val Leu Thr Asp Glu Gln Lys Ser Arg Ile Gln Ala 
 145                150                155                160
Met Lys Pro Met Thr Lys Glu Glu Trp Asp Ala Arg Gln Ser Val Ile 
                 165                170                175
Arg Lys Val Val Asp Pro Glu Thr Gly Arg Thr Arg Leu Ile Lys Gly 
             180                185                190
Asp Gly Glu Val Leu Glu Glu Ile Val Thr Lys Glu Arg His Arg Glu 
         195                200                205
Ile Asn Lys Gln Ala Thr Arg Gly Asp Gly Leu Ala Phe Gln Met Arg 
     210                215                220
Thr Gly Leu Leu Pro 
 225



<210> 5730
<211> 952
<212> DNA
<213> Homo sapiens
<308> AB035384
<400> 5730

gtcctctcg  gaaggcgcg  ggcgggctg  ccggcccgc  gggcggtcg  gcccgcggc  60
ccatggctc  cgtcggctc  cgcaagcgc  cgaggagtc  cagccggtc  cggggacgg  120
ggtcggaaa  gagaaagaa  aagagcagg  aagacacct  gaggaactg  tcggcctcc  180
catcccaag  gagaagcaa  cagaaggcc  ggaggagaa  aagatccag  tcctcctcc  240
cttcttcca  ttcttctag  tcctcttct  cctcctcgt  ctcctcctc  tcctccagt  300
atggccgga  gaagcgggg  aagtacaag  acaagagga  gaagaagaa  aagaagagg  360
agaagctga  gaagaaggg  aaggagaag  cggaagcac  gcaggtgga  gctctgccg  420
gcccctcgc  ggaccagtg  caccgatca  ctggggagg  agaggatgg  ccagtcctg  480
cggatgagc  gaagtcccg  atccaggcc  tgaagccca  gaccaagga  gagtgggat  540
cccggcaga  catcatccg  aaggtggtg  accctgaga  ggggcgcac  aggcttatt  600
agggagatg  cgaggtcct  gaggaaatc  taaccaaag  acgacacag  gagatcaac  660
agcaagcca  ccgagggga  tgcctggcc  tccagatgc  agctgggtt  cttccctga  720
ggcccccgc  ggccaaggc  tgtggacga  gctggcggc  cagcctggg  aggtttcag  780
gtgccagtg  gaagcctga  gggtgctgg  ggcctttcc  ccgtggatt  gtctctggc  840
cagcccagt  tcttctcag  ggcaggggg  ggaggttgg  gtcaccggc  tgcttggca  900
ccccatctg  aagagcagc  cttctcagc  attaaaggc  ccctggata  ac  952



<210> 5731
<211> 219
<212> PRT
<213> Homo sapiens
<308> AB035384
<400> 5731

Met Ala His Val Gly Ser Arg Lys Arg Ser Arg Ser Arg Ser Arg Ser 
  1               5                  10                  15
Arg Gly Arg Gly Ser Glu Lys Arg Lys Lys Lys Ser Arg Lys Asp Thr 
             20                  25                  30
Ser Arg Asn Cys Ser Ala Ser Thr Ser Gln Glu Arg Ser Lys Gln Lys 
         35                  40                  45
Ala Arg Arg Arg Thr Arg Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
     50                  55                  60
Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp 
 65                  70                  75                  80
Gly Arg Lys Lys Arg Gly Lys Tyr Lys Asp Lys Arg Arg Lys Lys Lys 
                 85                  90                  95
Lys Lys Arg Lys Lys Leu Lys Lys Lys Gly Lys Glu Lys Ala Glu Ala 
             100                105                110
Gln Gln Val Glu Ala Leu Pro Gly Pro Ser Leu Asp Gln Trp His Arg 
         115                120                125
Ser Ala Gly Glu Glu Glu Asp Gly Pro Val Leu Thr Asp Glu Gln Lys 
     130                135                140
Ser Arg Ile Gln Ala Met Lys Pro Met Thr Lys Glu Glu Trp Asp Ala 
 145                150                155                160
Arg Gln Ser Ile Ile Arg Lys Val Val Asp Pro Glu Thr Gly Arg Thr 
                 165                170                175
Arg Leu Ile Lys Gly Asp Gly Glu Val Leu Glu Glu Ile Val Thr Lys 
             180                185                190
Glu Arg His Arg Glu Ile Asn Lys Gln Ala Thr Arg Gly Asp Cys Leu 
         195                200                205
Ala Phe Gln Met Arg Ala Gly Leu Leu Pro Ter 
     210                215



<210> 5732
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AA892318
<400> 5732

gaacaagat  atttaatag  gaccctctg  tgtccactt  ggtgcctag  ccacccact  60
cacccaaga  gatgctggg  cgtaggaaa  gccgctgga  atcagtctc  aaactacca  120
cagcagttc  cagagctgg  atggcagtg  cctccctca  ggaagcagg  ctgctcgca  180
ctggaaggc  aggccgtcc  ctcgggtgg  ttgctgagg  aagaaacag  ttggaagca  240
gagaaacta  gtgtagaca  aatgagggc  gagcatagg  agagtggta  caccaacct  300
gttgatctc  ctgtgtcgt  ctttggtta  gatctcctc  aaaacctca  cgtctccct  360
gatgagcct  gtacggccg  tctctgggt  caccacctt  cgaataacg  tctgtcgag  420
gtcccactc  tcctttgtc  tgggcttca  ggcctggat  cgagacttc  gctcgtctg  480
caggactgg  ccatcattg  cctccccag  tgatctgtg  cactgatcc  gagaggggc  540
g  541



<210> 5733
<211> 229
<212> PRT
<213> Rattus norvegicus
<308> BAA94743
<400> 5733

Met Ala His Val Gly Ser Arg Lys Arg Ser Arg Ser Arg Ser Arg Ser 
  1               5                  10                  15
Arg Ser Gly Arg Arg Gly Ser Glu Lys Arg Ser Lys Arg Ser Ser Lys 
             20                  25                  30
Asp Ala Ser Arg Asn Cys Ser Ala Ser Arg Ser Gln Gly His Lys Ala 
         35                  40                  45
Gly Ser Ala Ser Gly Val Glu Glu Arg Ser Lys His Lys Ala Gln Arg 
     50                  55                  60
Thr Ser Arg Ser Ser Ser Thr Ser Ser Ser Ser Ser Ser Ser Ser Ser 
 65                  70                  75                  80
Ala Ser Ser Ser Ser Ser Ser Asp Gly Arg Lys Lys Arg Ala Lys His 
                 85                  90                  95
Lys Glu Lys Lys Arg Lys Lys Lys Lys Lys Lys Arg Lys Lys Lys Leu 
             100                105                110
Lys Lys Arg Val Lys Glu Lys Ala Val Ala Val His Gln Ala Glu Ala 
         115                120                125
Leu Pro Gly Pro Ser Leu Asp Gln Trp His Arg Ser Ala Gly Glu Asp 
     130                135                140
Asn Asp Gly Pro Val Leu Thr Asp Glu Gln Lys Ser Arg Ile Gln Ala 
 145                150                155                160
Met Lys Pro Met Thr Lys Glu Glu Trp Asp Ala Arg Gln Ser Val Ile 
                 165                170                175
Arg Lys Val Val Asp Pro Glu Thr Gly Arg Thr Arg Leu Ile Lys Gly 
             180                185                190
Asp Gly Glu Val Leu Glu Glu Ile Val Thr Lys Glu Arg His Arg Glu 
         195                200                205
Ile Asn Lys Gln Ala Thr Arg Gly Asp Gly Leu Ala Phe Gln Met Arg 
     210                215                220
Thr Gly Leu Leu Pro 
 225



<210> 5734
<211> 952
<212> DNA
<213> Homo sapiens
<308> AB035384
<400> 5734

gtcctctcg  gaaggcgcg  ggcgggctg  ccggcccgc  gggcggtcg  gcccgcggc  60
ccatggctc  cgtcggctc  cgcaagcgc  cgaggagtc  cagccggtc  cggggacgg  120
ggtcggaaa  gagaaagaa  aagagcagg  aagacacct  gaggaactg  tcggcctcc  180
catcccaag  gagaagcaa  cagaaggcc  ggaggagaa  aagatccag  tcctcctcc  240
cttcttcca  ttcttctag  tcctcttct  cctcctcgt  ctcctcctc  tcctccagt  300
atggccgga  gaagcgggg  aagtacaag  acaagagga  gaagaagaa  aagaagagg  360
agaagctga  gaagaaggg  aaggagaag  cggaagcac  gcaggtgga  gctctgccg  420
gcccctcgc  ggaccagtg  caccgatca  ctggggagg  agaggatgg  ccagtcctg  480
cggatgagc  gaagtcccg  atccaggcc  tgaagccca  gaccaagga  gagtgggat  540
cccggcaga  catcatccg  aaggtggtg  accctgaga  ggggcgcac  aggcttatt  600
agggagatg  cgaggtcct  gaggaaatc  taaccaaag  acgacacag  gagatcaac  660
agcaagcca  ccgagggga  tgcctggcc  tccagatgc  agctgggtt  cttccctga  720
ggcccccgc  ggccaaggc  tgtggacga  gctggcggc  cagcctggg  aggtttcag  780
gtgccagtg  gaagcctga  gggtgctgg  ggcctttcc  ccgtggatt  gtctctggc  840
cagcccagt  tcttctcag  ggcaggggg  ggaggttgg  gtcaccggc  tgcttggca  900
ccccatctg  aagagcagc  cttctcagc  attaaaggc  ccctggata  ac  952



<210> 5735
<211> 218
<212> PRT
<213> Homo sapiens
<308> NP_057722
<400> 5735

Met Ala His Val Gly Ser Arg Lys Arg Ser Arg Ser Arg Ser Arg Ser 
  1               5                  10                  15
Arg Gly Arg Gly Ser Glu Lys Arg Lys Lys Lys Ser Arg Lys Asp Thr 
             20                  25                  30
Ser Arg Asn Cys Ser Ala Ser Thr Ser Gln Glu Arg Ser Lys Gln Lys 
         35                  40                  45
Ala Arg Arg Arg Thr Arg Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
     50                  55                  60
Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp 
 65                  70                  75                  80
Gly Arg Lys Lys Arg Gly Lys Tyr Lys Asp Lys Arg Arg Lys Lys Lys 
                 85                  90                  95
Lys Lys Arg Lys Lys Leu Lys Lys Lys Gly Lys Glu Lys Ala Glu Ala 
             100                105                110
Gln Gln Val Glu Ala Leu Pro Gly Pro Ser Leu Asp Gln Trp His Arg 
         115                120                125
Ser Ala Gly Glu Glu Glu Asp Gly Pro Val Leu Thr Asp Glu Gln Lys 
     130                135                140
Ser Arg Ile Gln Ala Met Lys Pro Met Thr Lys Glu Glu Trp Asp Ala 
 145                150                155                160
Arg Gln Ser Ile Ile Arg Lys Val Val Asp Pro Glu Thr Gly Arg Thr 
                 165                170                175
Arg Leu Ile Lys Gly Asp Gly Glu Val Leu Glu Glu Ile Val Thr Lys 
             180                185                190
Glu Arg His Arg Glu Ile Asn Lys Gln Ala Thr Arg Gly Asp Cys Leu 
         195                200                205
Ala Phe Gln Met Arg Ala Gly Leu Leu Pro 
     210                215



<210> 5736
<211> 593
<212> DNA
<213> Rattus norvegicus
<308> AA892319
<400> 5736

caggagggt  ggaaacata  aaacagtac  ttttccttg  agaaaatta  tccatttac  60
taaccattt  gtacaaaca  catttatta  actgcattt  aggcaattc  taacagagt  120
acaggtgac  ctttgattt  tcacactgg  gctattatg  tttgcacac  aaataccaa  180
gctgttgaa  ttgccaaat  tctcttagt  attaaaaag  acaaaagaa  aaactgact  240
cagacagat  aagtaagtc  cagagcgag  gaatccagc  gttctttct  caataagca  300
acggccttg  ctttctaga  agtgcaaac  gtctctagc  ctctatcac  gctgcagtc  360
cccagaggc  accctgtag  tagccccct  cctgctgct  tctcctttt  tctttctca  420
accatgagt  gcactgagg  tgcctcacc  cttgaattt  cgtgactga  caaatcctg  480
agtgtaggc  tcagttatc  gtacttgga  atgcaacac  atgccatcc  cgggatgtt  540
tttgtactt  tatttttaa  gctaccctt  ctcgcccat  ttggttctg  aaa  593



<210> 5737
<211> 2213
<212> DNA
<213> Homo sapiens
<308> AK000396
<400> 5737

gttggccta  tggagccgc  ctgccaacc  tcccgcccg  ccgcgctcc  gtccgccgt  60
tctagcagc  gggcccagc  tggtcatgg  ggatggccc  aggcacttg  agcgcgggc  120
ggtccgggt  gggttctac  acatcgagg  cacgctggg  aagggcaac  tcgctgtgg  180
gaagctggg  cggcaccgg  tcaccaaga  ggaggtggc  ataaaaata  tcgataagt  240
tcagctgga  gcagtgaac  ttgagaaaa  ctaccgaga  gtacaaata  tgaaaatgt  300
agaccaccc  cacataatc  aactttatc  ggtaatgga  accaaaagt  tgttgtacc  360
tgtgacaga  tatgccaaa  atggagaaa  ttttgacta  cttgctaat  atggccggt  420
aaatgagtc  gaagccagg  gaaaattct  gcaaatcct  tctgctgtt  attattgtc  480
tggtcggaa  attgtgcac  gtgacctca  agctgaaaa  ctcctgctg  ataacaaca  540
gaatatcaa  atagcagat  tcggttttg  aaatttctt  aaaagtggt  aactgctgg  600
aacatggtg  ggcagcccc  cttatgcag  cccagaagt  tttgaaggg  agcagtatg  660
aggaccaca  ctggacatc  ggagtatgg  agttgttct  tatgtcctt  tctgtggag  720
tctgccctt  gatggaccg  ctcttccaa  tttgaggca  agggttctg  aaggaagat  780
ccggattcc  tatttcatg  cagaagatt  cgagcacct  atccgaagg  tgttggtcc  840
agacccatc  aaacggcta  ccatagccc  aatcaagga  cataaatgg  tgctcatag  900
agttcctgt  cagagacct  ttctctatc  acaagagca  gaaaatgag  catccatcg  960
ggagtttaa  gagcaggtt  tgcgactga  gcacagcct  ggaatagat  agcagaaag  1020
cattgagtc  ttgcagaac  agagctata  ccactttgc  gccatttat  tcttgttgg  1080
ggagcgcct  aaatcacat  ggagcagtt  cccagtgga  cagagactt  atggccgcc  1140
gcgtcggcc  agcaccatt  ctgagcaaa  agttgccaa  gcacagact  tggggctcc  1200
agtgaccat  cattcaccg  acatgaggc  gctgcgatc  gccctcctc  cccaggcat  1260
caacgtgga  gccttttca  ttccagcat  tggctgtca  gcggaagct  cattcatgg  1320
agaagagtg  gtggacact  caaaggtca  tggctgtct  cttgaccct  tgcctcctg  1380
cctggtgcg  aagggatgc  agtcactgc  cagcaacat  atggagacc  ccattgacg  1440
agggctgga  acagaagga  aggccgagg  agaccccgc  catgccttt  aggcatttc  1500
gtccacacg  agcgggcag  gacggcaca  tctgtcaga  gtgaccaat  aactggtcg  1560
gatgcctgg  gcagggaaa  ttttctcca  gaatgacag  ccctccctt  acagtgtgg  1620
ctctgagta  gatatgggg  ctgttcaga  ggacctgaa  tttctggaa  acaaccctt  1680
ccttaagga  atcatgtta  ccaatcagc  ttcaccaaa  tctctgaag  ggaaagaag  1740
ggagagaaa  gtttgcttc  cttcgggga  tgcagtttg  gaaataaaa  gggatacag  1800
gatatctgc  ctttgtaga  agggccaag  ttatttgct  atatctgaa  ggaggtggg  1860
ggttttgct  gatgtttgg  ctgaaagag  tacttttga  aaagttaat  taattgtag  1920
tatattttc  gtgtgcttt  ttttaatta  taagaaaaa  attggtgag  tcagtagct  1980
tggtattat  agtgcaaat  ataatagct  caatgtgaa  aaaaaaatc  aaagtataa  2040
ttgtcactt  atgttagaa  attgcctaa  atgcagtgt  ataaataat  tctgtacca  2100
atagtaatt  aaatggggt  attttctgc  aggaaaatg  actgttttt  tgtttccaa  2160
cctcttgaa  taaaataaa  acaacttct  ttctaaaaa  aaaaaaaaa  aaa  2213



<210> 5738
<211> 618
<212> DNA
<213> Rattus norvegicus
<308> AA892325
<400> 5738

aaaaaaata  aatggattg  cagttacca  attatctgc  tgctagcga  atttcccaa  60
cccgtgaga  acaccattt  ttgatcgat  ataaaatca  ttcctcaac  atgtacaga  120
aggaaacct  tccatccaa  tttaaggtc  ttatccctg  tctcacctc  caagctagt  180
ggatgtatg  gccacaagc  gagctcctt  cagaagaac  tctgagaag  caataaaca  240
ggtgttact  aaagatgat  atttgttaa  atcataaag  aaccatctt  tggcctgca  300
aaattttac  ttagattca  catcactgg  gatgtgctc  cctgatagt  atattctga  360
taatcacaa  cacacggta  tttccctgc  tgctttctg  agccaaacc  tgtttgaca  420
cacattcag  ttacaggat  tgacctgaa  ttcccgttc  aaacaggac  gttagggag  480
gttaccagt  acaaagaat  aaagttata  gacattgat  attagaaat  atatttgtt  540
ttatccacc  ccggtctcc  taatatgtt  aaatttctt  ttgcaggaa  catgagctt  600
gtagaaccc  gatacatc  618



<210> 5739
<211> 338
<212> PRT
<213> Rattus norvegicus
<308> BAB25375
<400> 5739

Met Ala Pro Asn Thr Ile Thr Leu Ile Gly Leu Ala Ile Asn Leu Val 
  1               5                  10                  15
Thr Thr Leu Val Leu Ile Phe Tyr Cys Pro Thr Val Thr Glu Glu Ala 
             20                  25                  30
Pro Tyr Trp Thr Tyr Leu Leu Cys Ala Leu Gly Leu Phe Ile Tyr Gln 
         35                  40                  45
Ser Leu Asp Ala Ile Asp Gly Lys Gln Ala Arg Arg Thr Asn Ser Cys 
     50                  55                  60
Ser Pro Leu Gly Glu Leu Phe Asp His Gly Cys Asp Ser Leu Ser Thr 
 65                  70                  75                  80
Val Phe Met Ala Ile Gly Ala Ser Ile Ala Val Arg Leu Gly Thr His 
                 85                  90                  95
Pro Asp Gly Leu Phe Phe Cys Ser Phe Val Gly Met Phe Met Phe Tyr 
             100                105                110
Cys Ala His Trp Gln Thr Tyr Val Ser Gly Val Leu Arg Phe Gly Arg 
         115                120                125
Val Asp Val Thr Glu Ile Gln Val Ala Leu Val Ile Val Phe Met Leu 
     130                135                140
Ser Thr Phe Gly Gly Ala Thr Met Trp Asp Tyr Thr Ile Pro Ile Leu 
 145                150                155                160
Glu Ile Lys Leu Lys Ile Val Pro Val Leu Gly Val Val Gly Gly Leu 
                 165                170                175
Ile Phe Ser Cys Ser Asn Tyr Phe His Val Ile Leu His Gly Gly Val 
             180                185                190
Gly Lys Asn Gly Ser Thr Ile Ala Gly Thr Ser Val Leu Ser Pro Gly 
         195                200                205
Leu His Ile Gly Leu Ile Ile Ile Leu Ala Ile Met Ile Tyr Lys Lys 
     210                215                220
Ser Ala Thr Asn Met Phe Glu Lys His Pro Cys Leu Tyr Thr Leu Met 
 225                230                235                240
Phe Gly Cys Val Phe Ala Lys Val Ala Gln Lys Leu Val Ile Ala His 
                 245                250                255
Met Thr Lys Ser Glu Leu Tyr Leu Gln Asp Thr Val Phe Ile Gly Pro 
             260                265                270
Gly Leu Leu Phe Leu Asp Gln Tyr Phe Asn Asn Phe Ile Asp Glu Tyr 
         275                280                285
Val Val Leu Trp Ile Ala Met Val Ile Ser Ser Phe Asp Met Met Ile 
     290                295                300
Tyr Phe Thr Ser Leu Cys Leu Gln Ile Ser Arg His Leu His Leu Asn 
 305                310                315                320
Ile Phe Lys Thr Ser Cys Gln Gln Ala Pro Glu Gln Val Tyr Lys His 
                 325                330                335
Ile Asp 
             340



<210> 5740
<211> 508
<212> DNA
<213> Rattus norvegicus
<308> AA892353
<400> 5740

gaagggagg  gttggcatt  atttctgga  cagggcctc  gcactggac  caattatgc  60
tgaagtcaa  acacagact  gtatagtaa  taggatagt  tcggaggtg  ctgacatgc  120
cagatgtca  gaagtccac  ccgcgcact  agacctggt  agccaggcg  tcctccacc  180
tccgttcca  atccctggc  gagaccacc  tatcagctc  agagtagag  tagagctcg  240
gccagcagg  gcctgaatc  tgcagcctg  cgtagaagt  ggtgtggaa  agggccgtg  300
atggagcaa  caggaagtg  aacaggacc  ccaccagcg  aaatgctgc  aggagcaac  360
ggcgaagca  ggcaggtct  cgctccagg  tggttgcca  ggccctcag  gcccctatc  420
ggtcgctat  cccagggcc  ctgtcaaag  tggtgccca  cacatgcaa  tggcggaag  480
gctgatggg  ctgaatgag  tccagcac  508



<210> 5741
<211> 261
<212> PRT
<213> Rattus norvegicus
<308> BAB24300
<400> 5741

Met Asn Pro Asp Gly Lys Asn Arg Gln Gly Gly Lys Glu Ala Gly Lys 
  1               5                  10                  15
Gln Gln Pro Val Val Ile Leu Leu Gly Trp Gly Gly Cys Arg Asp Lys 
             20                  25                  30
Asn Leu Ala Lys Tyr Ser Ala Ile Tyr His Lys Arg Gly Cys Ile Val 
         35                  40                  45
Ile Arg Tyr Thr Ala Pro Trp His Met Val Phe Phe Ser Glu Ser Leu 
     50                  55                  60
Gly Ile Pro Ser Leu Arg Val Ile Ala Gln Lys Leu Leu Glu Leu Leu 
 65                  70                  75                  80
Phe Asp Tyr Glu Ile Glu Arg Glu Pro Leu Leu Phe His Val Phe Ser 
                 85                  90                  95
Asn Ala Gly Val Met Leu Tyr Arg Tyr Val Leu Glu Leu Leu Gln Thr 
             100                105                110
His Gln Arg Phe Arg His Leu His Val Val Gly Thr Ile Phe Asp Ser 
         115                120                125
Gly Pro Gly Asp Ser Asn Leu Ile Gly Ala Leu Arg Ala Leu Ala Thr 
     130                135                140
Ile Leu Glu Arg Arg Pro Ala Val Leu Arg Leu Leu Leu Leu Ala Ala 
 145                150                155                160
Phe Ala Leu Val Val Ile Leu Phe His Phe Leu Leu Ala Pro Phe Thr 
                 165                170                175
Ala Leu Phe His Thr His Phe Tyr Asp Arg Leu Gln Asp Ser Gly Ser 
             180                185                190
Cys Trp Pro Glu Leu Tyr Leu Tyr Ser Arg Ala Asp Lys Val Val Ser 
         195                200                205
Ala Arg Asp Val Glu Arg Met Val Glu Ala Arg Leu Ala His Gln Val 
     210                215                220
Met Val Arg Gly Val Asp Phe Val Ser Ser Ala His Val Ser His Leu 
 225                230                235                240
Arg Asp Tyr Pro Thr Tyr Tyr Thr Ser Leu Cys Val Asp Phe Met His 
                 245                250                255
Asn Cys Val Gln Cys 
             260



<210> 5742
<211> 508
<212> DNA
<213> Rattus norvegicus
<308> AA892353
<400> 5742

gaagggagg  gttggcatt  atttctgga  cagggcctc  gcactggac  caattatgc  60
tgaagtcaa  acacagact  gtatagtaa  taggatagt  tcggaggtg  ctgacatgc  120
cagatgtca  gaagtccac  ccgcgcact  agacctggt  agccaggcg  tcctccacc  180
tccgttcca  atccctggc  gagaccacc  tatcagctc  agagtagag  tagagctcg  240
gccagcagg  gcctgaatc  tgcagcctg  cgtagaagt  ggtgtggaa  agggccgtg  300
atggagcaa  caggaagtg  aacaggacc  ccaccagcg  aaatgctgc  aggagcaac  360
ggcgaagca  ggcaggtct  cgctccagg  tggttgcca  ggccctcag  gcccctatc  420
ggtcgctat  cccagggcc  ctgtcaaag  tggtgccca  cacatgcaa  tggcggaag  480
gctgatggg  ctgaatgag  tccagcac  508



<210> 5743
<211> 261
<212> PRT
<213> Rattus norvegicus
<308> BAB24300
<400> 5743

Met Asn Pro Asp Gly Lys Asn Arg Gln Gly Gly Lys Glu Ala Gly Lys 
  1               5                  10                  15
Gln Gln Pro Val Val Ile Leu Leu Gly Trp Gly Gly Cys Arg Asp Lys 
             20                  25                  30
Asn Leu Ala Lys Tyr Ser Ala Ile Tyr His Lys Arg Gly Cys Ile Val 
         35                  40                  45
Ile Arg Tyr Thr Ala Pro Trp His Met Val Phe Phe Ser Glu Ser Leu 
     50                  55                  60
Gly Ile Pro Ser Leu Arg Val Ile Ala Gln Lys Leu Leu Glu Leu Leu 
 65                  70                  75                  80
Phe Asp Tyr Glu Ile Glu Arg Glu Pro Leu Leu Phe His Val Phe Ser 
                 85                  90                  95
Asn Ala Gly Val Met Leu Tyr Arg Tyr Val Leu Glu Leu Leu Gln Thr 
             100                105                110
His Gln Arg Phe Arg His Leu His Val Val Gly Thr Ile Phe Asp Ser 
         115                120                125
Gly Pro Gly Asp Ser Asn Leu Ile Gly Ala Leu Arg Ala Leu Ala Thr 
     130                135                140
Ile Leu Glu Arg Arg Pro Ala Val Leu Arg Leu Leu Leu Leu Ala Ala 
 145                150                155                160
Phe Ala Leu Val Val Ile Leu Phe His Phe Leu Leu Ala Pro Phe Thr 
                 165                170                175
Ala Leu Phe His Thr His Phe Tyr Asp Arg Leu Gln Asp Ser Gly Ser 
             180                185                190
Cys Trp Pro Glu Leu Tyr Leu Tyr Ser Arg Ala Asp Lys Val Val Ser 
         195                200                205
Ala Arg Asp Val Glu Arg Met Val Glu Ala Arg Leu Ala His Gln Val 
     210                215                220
Met Val Arg Gly Val Asp Phe Val Ser Ser Ala His Val Ser His Leu 
 225                230                235                240
Arg Asp Tyr Pro Thr Tyr Tyr Thr Ser Leu Cys Val Asp Phe Met His 
                 245                250                255
Asn Cys Val Gln Cys 
             260



<210> 5744
<211> 622
<212> DNA
<213> Rattus norvegicus
<308> AA892364
<400> 5744

gaacatttt  tttctccaa  aaacactca  aagagttta  tttgtggga  ataacatta  60
ccccagaat  gtgtatttt  ttcccacat  tcctgcttt  aattaggaa  tgatattgt  120
atccatttc  ctacaagga  aatattaca  aatatttac  ggaaaatat  aaaaataac  180
caaacacaa  agtcaagat  aaataaact  tcttcctcc  gaattctct  ccctagtgc  240
catggcaca  gagtcaaaa  aagtaacta  gacctcgct  atagaattc  caaaatgga  300
aggggaaga  gggaggaga  ggtggtgtc  gggaatggg  ctagcagca  tgcttcaca  360
cctggtcta  tacacctga  agtgcactt  gctcttctc  ctaagttta  cgagagcct  420
ttgttccac  aaccagtcc  ctgaggaga  gcctgcact  gcaggacaa  ctgtcacag  480
agcccttcc  tctctttca  aaacgcttc  tagacatcg  ccttagtct  taccgacac  540
ggaactgaa  gcccagatc  gggggctgc  ttggccaca  gcacagcag  gtcctcctc  600
gaccttctt  ggggaacgg  ag  622



<210> 5745
<211> 389
<212> PRT
<213> Rattus norvegicus
<308> NP_068360
<400> 5745

Met Tyr Gly Arg Lys Val Gly Phe Ala Leu Asp Leu Pro Pro Arg Arg 
  1               5                  10                  15
Arg Asp Glu Asp Met Leu Tyr Ser Pro Glu Leu Ala Gln Arg Gly His 
             20                  25                  30
Asp Asp Asp Met Ser Ser Thr Ser Glu Asp Asp Gly Tyr Pro Glu Asp 
         35                  40                  45
Met Asp Gln Asp Lys His Asp Asp Ser Thr Glu Asp Ser Asp Thr Asp 
     50                  55                  60
Arg Ser Asp Ala Glu Ser Asp Gly Asp Glu Phe Gly His Arg Glu Asp 
 65                  70                  75                  80
Ser Glu Arg Asp Asn Thr Glu Glu Lys Lys Ser Gly Leu Ser Val Arg 
                 85                  90                  95
Phe Ala Asp Met Pro Gly Lys Ser Arg Lys Lys Lys Lys Asn Met Lys 
             100                105                110
Glu Leu Thr Pro Leu Gln Ala Met Met Leu Arg Met Ala Gly Gln Glu 
         115                120                125
Ile Pro Glu Glu Gly Arg Glu Val Glu Glu Phe Ser Glu Glu Glu Asp 
     130                135                140
Ala Asp Asp Ser Asp Asp Ser Glu Ala Glu Lys Gln Ser Gln Lys Gln 
 145                150                155                160
His Lys Asp Asp Ala His Ser Asp Ser Thr Ala Ala Ala Ser Ser Gln 
                 165                170                175
Gln Gln Ala Pro Pro Gln Ser Ala Pro Ala Ser Gln Ile Gln Ala Pro 
             180                185                190
Pro Met Pro Gly Pro Pro Pro Leu Gly Pro Pro Pro Ala Pro Pro Leu 
         195                200                205
Arg Pro Pro Gly Pro Pro Thr Gly Leu Pro Pro Gly Pro Pro Pro Gly 
     210                215                220
Ala Pro Pro Phe Leu Arg Pro Pro Gly Met Pro Gly Ile Arg Gly Pro 
 225                230                235                240
Leu Pro Arg Leu Leu Pro Pro Gly Pro Pro Pro Gly Arg Pro Pro Gly 
                 245                250                255
Pro Pro Pro Gly Pro Pro Pro Gly Leu Pro Pro Gly Pro Pro Pro Arg 
             260                265                270
Gly Pro Pro Pro Arg Leu Pro Pro Pro Ala Pro Pro Gly Ile Pro Pro 
         275                280                285
Pro Arg Pro Gly Met Met Arg Pro Pro Leu Val Pro Pro Leu Gly Pro 
     290                295                300
Ala Pro Pro Gly Leu Phe Pro Pro Ala Pro Leu Pro Asn Pro Gly Val 
 305                310                315                320
Leu Ser Ala Pro Pro Ser Leu Ile Gln Arg Pro Lys Ala Asp Asp Ala 
                 325                330                335
Ser Ala Ala Thr Ile Glu Lys Lys Ala Thr Ala Thr Ile Ser Ala Lys 
             340                345                350
Pro Gln Ile Thr Asn Pro Lys Ala Glu Val Thr Arg Phe Val Pro Thr 
         355                360                365
Ala Leu Arg Val Arg Arg Glu Asn Lys Gly Ala Thr Ala Val Pro Gln 
     370                375                380
Lys Lys Val Arg Gly 
 385



<210> 5746
<211> 2654
<212> DNA
<213> Homo sapiens
<308> AB029309
<400> 5746

ggcacgagg  gagacccag  tgacggcct  tacgaagtg  aagaggccg  gaatcgccc  60
ctacccgct  ctcgtagtc  tgggagcac  gcagaagtg  ttttctttt  ttaatgaac  120
agtaaacca  acaaattgt  aacatggga  ggagatcta  atcatccac  aagagtgga  180
aatttatga  ccccacaga  caagcccga  aggaagccc  gaagagaga  ttaaagaag  240
acaaaaaac  gcgcatgat  gttcgagct  cagttttaa  gatgaagga  ccaaaacag  300
taatccgag  catggagaa  ttggatgaa  tggagttta  cccagtgca  cagccacaa  360
taaatgaga  agtactgaa  gacaagcgt  aaaagctgc  tgaaacctt  gaacgtatt  420
tacgactct  tgaaaaaga  aatccagat  tttacaaag  attgagaaa  ctagaagta  480
aatatgaac  gaagagggc  caacttagc  aatattttg  tgctgtcaa  aatgctcag  540
atgtggaag  ggagagtat  cctttgcca  atatgccac  tgctccttc  aacattttg  600
tccaggaca  tccacttcc  ggtgcccag  caccctcta  cctaaagaa  acctcagcc  660
atggacctc  aactcgggc  gtttctatc  ttcctcttc  tggacatgg  gttccacgt  720
tgccccctg  cagaaaacc  cctggccct  cccctggtc  acctcctcc  caagtcgtg  780
agatgtatg  ccgtaaagt  ggttttgcc  tagatcttc  ccctcgtag  cgagatgaa  840
acatgttat  tagtcctga  cttgcccag  gaggtcatg  tgatgatgt  tctagcacc  900
gtgaagatg  tggctatcc  gaggacatg  atcaagata  gcatgatga  agtactgat  960
acagtgaca  cgacaaatc  gatggagaa  gtgacgggg  tgaatttgt  caccgtgat  1020
atggtgaga  agacaacaa  gaagaaaag  agtcaggtc  gagtgtacg  tttgcagat  1080
tgcctggaa  atcaaggaa  aaaaagaag  acatgaagg  actgactcc  cttcaagcc  1140
tgatgcttc  tatggcagg  caagaaatc  ctgaggagg  acgggaagt  gaggaattt  1200
cagaggacg  tgatgaaga  gattctgat  actctgaag  agaaaagca  tcacaaaag  1260
agcataaag  ggaatccca  tctgatggc  catccactg  ttcttcaca  cagcaggct  1320
cgccgcagt  tgttcctcc  tctcagata  aagcacctc  catgccagg  ccaccacct  1380
ttggaccac  acctgctcc  ccattacgg  ctcctgggc  acctacagg  cttcctcct  1440
gtccacctc  aggagctcc  ccattcctg  gaccacctg  aatgccagg  ctccgaggg  1500
ccttacccc  acttttacc  ccaggacca  caccaggcc  accccctgg  cctccccca  1560
gtccacctc  aggtctgcc  cctggtccc  ctcctcgtg  acccccacc  aggctacct  1620
cccctgcac  tccaggtat  cctccacct  gtcctggca  gatgcgccc  cctttggtg  1680
ctccccttg  acctgcccc  cctgggctg  tcccaccag  tcccttgcc  aaccctggg  1740
ttttaagtg  cccacccaa  ttgattcag  gacccaagg  ggatgatac  agtgcagcc  1800
ccattgaga  gaaagccac  gcaaccatc  gtgccaagc  acagatcac  aatcccaag  1860
cagagatta  tcgatttgt  cccactgca  tgagagtac  tcgggagaa  aaaggggct  1920
ctgctgctc  ccaaagaaa  tcagaggat  attctgctg  gcctcttgc  aaagcagca  1980
ccaaatctg  tccttctgt  cctgtctca  tacaaacta  ggatgatgt  tatgaggct  2040
tcatgaaag  gatggaagg  ctactgtga  agcttttga  gccagaaaa  gcttctgtt  2100
acaacagtg  cccatggag  aagaggctc  tattaaact  agatgaaag  gctgcttcc  2160
ttgtcaggg  attttctaa  ttcagttca  ggaatatcc  aaaatttag  cttgttcag  2220
atttactgc  cataaaaaa  ggtatttca  ccagaatag  tcagttatt  aagcagtgc  2280
gctaacatc  attcccttt  ataccacca  tttcaccct  tttcttccc  tcctccagt  2340
ctttggaaa  ttgtgatcg  gggatctta  ttgcttatt  gttttgact  ttgtgtgct  2400
tgggcactg  agtagagat  tctggagaa  aaaaaacag  ttatttcat  ttgcctttt  2460
tgtttgagt  atttttaat  ttttcctgt  aatattttg  aatatttta  ttgtaatga  2520
atggatcac  atgtcattt  ctaatacaa  gcaggatat  tgggaagaa  atgtacaat  2580
atttgatta  aattatttc  cactgacct  aactttcag  gatttgtgg  aaaaataaa  2640
aaatgttct  cacc  2654



<210> 5747
<211> 641
<212> PRT
<213> Homo sapiens
<308> NP_057396
<400> 5747

Met Gly Arg Arg Ser Thr Ser Ser Thr Lys Ser Gly Lys Phe Met Asn 
  1               5                  10                  15
Pro Thr Asp Gln Ala Arg Lys Glu Ala Arg Lys Arg Glu Leu Lys Lys 
             20                  25                  30
Asn Lys Lys Gln Arg Met Met Val Arg Ala Ala Val Leu Lys Met Lys 
         35                  40                  45
Asp Pro Lys Gln Ile Ile Arg Asp Met Glu Lys Leu Asp Glu Met Glu 
     50                  55                  60
Phe Asn Pro Val Gln Gln Pro Gln Leu Asn Glu Lys Val Leu Lys Asp 
 65                  70                  75                  80
Lys Arg Lys Lys Leu Arg Glu Thr Phe Glu Arg Ile Leu Arg Leu Tyr 
                 85                  90                  95
Glu Lys Glu Asn Pro Asp Ile Tyr Lys Glu Leu Arg Lys Leu Glu Val 
             100                105                110
Glu Tyr Glu Gln Lys Arg Ala Gln Leu Ser Gln Tyr Phe Asp Ala Val 
         115                120                125
Lys Asn Ala Gln His Val Glu Val Glu Ser Ile Pro Leu Pro Asp Met 
     130                135                140
Pro His Ala Pro Ser Asn Ile Leu Ile Gln Asp Ile Pro Leu Pro Gly 
 145                150                155                160
Ala Gln Pro Pro Ser Ile Leu Lys Lys Thr Ser Ala Tyr Gly Pro Pro 
                 165                170                175
Thr Arg Ala Val Ser Ile Leu Pro Leu Leu Gly His Gly Val Pro Arg 
             180                185                190
Leu Pro Pro Gly Arg Lys Pro Pro Gly Pro Pro Pro Gly Pro Pro Pro 
         195                200                205
Pro Gln Val Val Gln Met Tyr Gly Arg Lys Val Gly Phe Ala Leu Asp 
     210                215                220
Leu Pro Pro Arg Arg Arg Asp Glu Asp Met Leu Tyr Ser Pro Glu Leu 
 225                230                235                240
Ala Gln Arg Gly His Asp Asp Asp Val Ser Ser Thr Ser Glu Asp Asp 
                 245                250                255
Gly Tyr Pro Glu Asp Met Asp Gln Asp Lys His Asp Asp Ser Thr Asp 
             260                265                270
Asp Ser Asp Thr Asp Lys Ser Asp Gly Glu Ser Asp Gly Asp Glu Phe 
         275                280                285
Val His Arg Asp Asn Gly Glu Arg Asp Asn Asn Glu Glu Lys Lys Ser 
     290                295                300
Gly Leu Ser Val Arg Phe Ala Asp Met Pro Gly Lys Ser Arg Lys Lys 
 305                310                315                320
Lys Lys Asn Met Lys Glu Leu Thr Pro Leu Gln Ala Met Met Leu Arg 
                 325                330                335
Met Ala Gly Gln Glu Ile Pro Glu Glu Gly Arg Glu Val Glu Glu Phe 
             340                345                350
Ser Glu Asp Asp Asp Glu Asp Asp Ser Asp Asp Ser Glu Ala Glu Lys 
         355                360                365
Gln Ser Gln Lys Gln His Lys Glu Glu Ser His Ser Asp Gly Thr Ser 
     370                375                380
Thr Ala Ser Ser Gln Gln Gln Ala Pro Pro Gln Ser Val Pro Pro Ser 
 385                390                395                400
Gln Ile Gln Ala Pro Pro Met Pro Gly Pro Pro Pro Leu Gly Pro Pro 
                 405                410                415
Pro Ala Pro Pro Leu Arg Pro Pro Gly Pro Pro Thr Gly Leu Pro Pro 
             420                425                430
Gly Pro Pro Pro Gly Ala Pro Pro Phe Leu Arg Pro Pro Gly Met Pro 
         435                440                445
Gly Leu Arg Gly Pro Leu Pro Arg Leu Leu Pro Pro Gly Pro Pro Pro 
     450                455                460
Gly Arg Pro Pro Gly Pro Pro Pro Gly Pro Pro Pro Gly Leu Pro Pro 
 465                470                475                480
Gly Pro Pro Pro Arg Gly Pro Pro Pro Arg Leu Pro Pro Pro Ala Pro 
                 485                490                495
Pro Gly Ile Pro Pro Pro Arg Pro Gly Met Met Arg Pro Pro Leu Val 
             500                505                510
Pro Pro Leu Gly Pro Ala Pro Pro Gly Leu Phe Pro Pro Ala Pro Leu 
         515                520                525
Pro Asn Pro Gly Val Leu Ser Ala Pro Pro Asn Leu Ile Gln Arg Pro 
     530                535                540
Lys Ala Asp Asp Thr Ser Ala Ala Thr Ile Glu Lys Lys Ala Thr Ala 
 545                550                555                560
Thr Ile Ser Ala Lys Pro Gln Ile Thr Asn Pro Lys Ala Glu Ile Thr 
                 565                570                575
Arg Phe Val Pro Thr Ala Leu Arg Val Arg Arg Glu Asn Lys Gly Ala 
             580                585                590
Thr Ala Ala Pro Gln Arg Lys Ser Glu Asp Asp Ser Ala Val Pro Leu 
         595                600                605
Ala Lys Ala Ala Pro Lys Ser Gly Pro Ser Val Pro Val Ser Val Gln 
     610                615                620
Thr Lys Asp Asp Val Tyr Glu Ala Phe Met Lys Glu Met Glu Gly Leu 
 625                630                635                640
Leu 
                 645



<210> 5748
<211> 719
<212> DNA
<213> Rattus norvegicus
<308> AA892373
<400> 5748

atacattta  taggataat  tcacataaa  taataagat  ggcacaaac  aagaaggaa  60
gagtcagga  aaagtgtca  tgccatttt  gtttgcagg  tagagtcag  aaatggaac  120
aactgagat  actagggaa  cattctaaa  ccaccccaa  ctagctaaa  ttacataat  180
ttaggactc  agtgccaaa  tagatatta  ccacttaat  tacgagtga  aaagagact  240
caaaattta  cctatttag  ataacaact  ttacatgaa  tatatagca  tttgtatct  300
agaaagcaa  acggcaact  ttaggcgtt  cctttatgc  gtgactaga  aatcttggt  360
cagctaggc  gctctgcga  accagtaag  tgctcaggg  tagcataga  cagcttgat  420
gagagctaa  ctctcaggt  tcagaaggc  gcaataatt  tattttggc  tttattcta  480
atgcttact  tagttaagg  gacaactga  gcacattaa  tgaaggtag  tagaattta  540
tgacaatca  tagtctctt  ccacctaca  agaactgta  aatgctttt  tggaatgga  600
gtgttgatt  actggaatt  tacacactc  cacacaaac  taanaagta  cgatcaaag  660
caatcatcc  acaggtact  tgctgatgt  ctacaatcc  catatgcca  agaactgaa  719



<210> 5749
<211> 300
<212> PRT
<213> Rattus norvegicus
<308> Q9JI92
<400> 5749

Met Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile 
  1               5                  10                  15
Gln Ala Gln Thr Ala Ser Ser Ala Asn Pro Ala Ser Gln Ala Phe Phe 
             20                  25                  30
Leu Asn Val Val Asp Ser Ala Ala Phe Pro Pro Gly Gly Asn Leu Tyr 
         35                  40                  45
Pro Lys Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Ser 
     50                  55                  60
Glu Ala Glu Ile Cys Glu Asn Met Pro Val Val Ser Gly Ala Pro Thr 
 65                  70                  75                  80
Gln Gly Gln Leu Val Ala Arg Pro Ser Ser Val Asn Tyr Met Val Ala 
                 85                  90                  95
Pro Val Thr Gly Asn Asp Ala Gly Ile Arg Arg Ala Glu Ile Lys Gln 
             100                105                110
Gly Ile Arg Glu Val Ile Leu Cys Lys Asp Gln Asp Gly Lys Ile Gly 
         115                120                125
Leu Arg Leu Lys Ser Val Asp Asn Gly Ile Phe Val Gln Leu Val Gln 
     130                135                140
Ala Asn Ser Pro Ala Ser Leu Val Gly Leu Arg Phe Gly Asp Gln Val 
 145                150                155                160
Leu Gln Ile Asn Gly Glu Asn Cys Ala Gly Trp Ser Ser Asp Lys Ala 
                 165                170                175
His Lys Val Leu Lys Gln Ala Phe Gly Glu Lys Ile Thr Met Thr Ile 
             180                185                190
Arg Asp Arg Pro Phe Glu Arg Thr Val Thr Met His Lys Asp Ser Ser 
         195                200                205
Gly His Val Gly Phe Ile Phe Lys Ser Gly Lys Ile Thr Ser Ile Val 
     210                215                220
Lys Asp Ser Ser Ala Ala Arg Asn Gly Leu Leu Thr Asp His His Ile 
 225                230                235                240
Cys Glu Ile Asn Gly Gln Asn Val Ile Gly Leu Lys Asp Ala Gln Ile 
                 245                250                255
Ala Asp Ile Leu Ser Thr Ala Gly Thr Val Val Thr Ile Thr Ile Met 
             260                265                270
Pro Ala Phe Ile Phe Glu His Ile Ile Lys Arg Met Ala Pro Ser Ile 
         275                280                285
Met Lys Ser Leu Met Asp His Thr Ile Pro Glu Val 
     290                295                300



<210> 5750
<211> 1971
<212> DNA
<213> Homo sapiens
<308> U83463
<400> 5750

gtgggctag  agaatcctg  aaaaatgtc  ctctatcca  ctctcgaag  cttgaaggt  60
gacaaagta  ttcaggctc  aactgcttt  tctgcaaac  ctgccaatc  agcaatttt  120
tcagaagct  ctgctccta  ccctcacga  ggaaatctc  atcccagac  gtatccaga  180
ctctctcaa  acatggggc  gagtttaag  gaagaagaa  tacgtgcaa  tgtggccgt  240
gtttctggt  caccacttc  ggggcagtt  gtagcaaga  cttccagta  aaactatat  300
gtggctcct  taactggta  tgatgttgg  attcgtaga  cagaaatta  gcaagggat  360
cgtgaagtc  ttttgtgta  ggatcaaga  ggaaaaatt  gactcaggc  taaatcaat  420
gataatggt  tatttgtcc  gctagtcca  gctaattct  cagcctcat  ggttggtct  480
agatttggg  accaagtac  tcagatcaa  ggtgaaaac  gtgcaggat  gagctctga  540
aaagcgcac  aggtgctca  acaggcttt  ggagagaag  ttaccatga  cattcgtga  600
aggcccttt  aacggacga  taccatgca  aaggatagc  ctggacatg  tggttttat  660
tttaaaaat  gaaaaataa  atccatagt  aaagatagc  ctgcagcca  aaatggtct  720
ctcacggaa  ataacatct  tgaaatcaa  ggacagaat  tcattggat  gaaggactc  780
caaattgca  acatactgt  aacatctgg  actgtagtt  ctattacaa  catgcctgc  840
tttatcttt  aacatatta  taagcggat  gcaccaagc  ttatgaaaa  cctaatgga  900
cacaccatt  ctgaggttt  aaattcacg  caccatgga  atgtagctg  acgtctcca  960
tttccttct  tggcaactt  tgtattatg  acgtgaagc  ttcccggag  cagcgagca  1020
atgctgcat  aggaccttt  tatcttaca  tatggctgg  aatcttact  tttcatctg  1080
taccttgtt  agatttcaa  atagttgta  ccttatcct  gttttacag  tgtgaaact  1140
tcaagagat  tactgactt  cctagaata  tttctctac  ggaaacctg  tgcttttat  1200
agccattgt  attaggatg  ctgttacag  cttagcttt  tgtgaaaac  agtcacctt  1260
ctcctaggt  atgagtagt  ctgttcata  tactttagt  ctatagcat  cttgcatct  1320
taacatgct  tcatagtac  tttagaatg  ttgcctttg  ttttttttt  aaattctgt  1380
tgtgtgtgt  taaaatgcc  attaagaac  ctggtttca  tccatgtaa  cattaaaca  1440
tgtatgtag  tttcaagag  ttgtgatga  tcttaaatt  taactacct  cacttaata  1500
gcttgaact  tcgccttaa  tatgttaag  atctagact  aaagccaaa  tataattat  1560
gctgccttt  taaaaaccc  aaatgtagt  ctctattaa  ctgaaatgt  cactagccc  1620
gaacagttt  atggtactt  ctgagctat  gcatagctg  ttagttgtt  ttgagattt  1680
ttagtcaac  cataatgga  acttctttc  tctaaaagt  gccagtgcc  cttttaaga  1740
gtgaatcac  atatgtgat  taaaagtta  tacactaaa  aggataaac  tttgactcc  1800
cttttgttc  tttgtggat  aagtggtat  atacttaat  ttggcattt  actcttaag  1860
ttatgtaac  tagctactt  gggatggtc  tagaatatt  ttctgataa  ttgttcctt  1920
tcctgactc  tccttgcaa  caaaatgat  gttgacact  tatcctgat  t  1971



<210> 5751
<211> 298
<212> PRT
<213> Homo sapiens
<308> O00560
<400> 5751

Met Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile 
  1               5                  10                  15
Gln Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn Pro Ala Ile Leu 
             20                  25                  30
Ser Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn Leu Tyr Pro Arg 
         35                  40                  45
Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn Glu Glu 
     50                  55                  60
Glu Ile Arg Ala Asn Val Ala Val Val Ser Gly Ala Pro Leu Gln Gly 
 65                  70                  75                  80
Gln Leu Val Ala Arg Pro Ser Ser Ile Asn Tyr Met Val Ala Pro Val 
                 85                  90                  95
Thr Gly Asn Asp Val Gly Ile Arg Arg Ala Glu Ile Lys Gln Gly Ile 
             100                105                110
Arg Glu Val Ile Leu Cys Lys Asp Gln Asp Gly Lys Ile Gly Leu Arg 
         115                120                125
Leu Lys Ser Ile Asp Asn Gly Ile Phe Val Gln Leu Val Gln Ala Asn 
     130                135                140
Ser Pro Ala Ser Leu Val Gly Leu Arg Phe Gly Asp Gln Val Leu Gln 
 145                150                155                160
Ile Asn Gly Glu Asn Cys Ala Gly Trp Ser Ser Asp Lys Ala His Lys 
                 165                170                175
Val Leu Lys Gln Ala Phe Gly Glu Lys Ile Thr Met Thr Ile Arg Asp 
             180                185                190
Arg Pro Phe Glu Arg Thr Ile Thr Met His Lys Asp Ser Thr Gly His 
         195                200                205
Val Gly Phe Ile Phe Lys Asn Gly Lys Ile Thr Ser Ile Val Lys Asp 
     210                215                220
Ser Ser Ala Ala Arg Asn Gly Leu Leu Thr Glu His Asn Ile Cys Glu 
 225                230                235                240
Ile Asn Gly Gln Asn Val Ile Gly Leu Lys Asp Ser Gln Ile Ala Asp 
                 245                250                255
Ile Leu Ser Thr Ser Gly Thr Val Val Thr Ile Thr Ile Met Pro Ala 
             260                265                270
Phe Ile Phe Glu His Ile Ile Lys Arg Met Ala Pro Ser Ile Met Lys 
         275                280                285
Ser Leu Met Asp His Thr Ile Pro Glu Val 
     290                295



<210> 5752
<211> 624
<212> DNA
<213> Rattus norvegicus
<308> AA892376
<400> 5752

gttttcctt  tggtttaat  aaagactgg  gaataaaca  aaataccgc  caatgacca  60
atcattctt  atactgtgc  cacacagac  aatgaacag  aatcgcaaa  aaacttgca  120
tcagcagtg  aatgcactc  gcttttctt  cccttgttt  aaaaaaaaa  gaaccgaaa  180
ccacaaatt  agaatctcg  cagcacata  tctgctgtg  caaatgatt  aaacataaa  240
agtggatgt  aagaaacta  atgctaaca  atgtataac  tttgttaat  aaaaaccaa  300
caaacagaa  cagccgtaa  gattaagat  cattcagtt  ctgataact  gttgtaccc  360
gaagggcct  atcaaaagg  aatcgtgct  cagagaaaa  ctatatata  atacacaat  420
agaaataaa  tgcaagatc  acgcatgca  gtttaatac  ggaaaaaaa  cacagccct  480
cagaatttc  ccacatttg  tataaaagc  ctctgcact  aactaaaat  aaaatgatc  540
taaaagtat  atacttctt  tcagccaca  aaactgcaa  ggaaataaa  gttcagagt  600
attttcaaa  canaaacaa  aatc  624



<210> 5753
<211> 223
<212> PRT
<213> Rattus norvegicus
<308> NP_075361
<400> 5753

Met Ala Gln Glu Thr Asn His Ser Gln Ala Pro Met Leu Cys Ser Thr 
  1               5                  10                  15
Gly Cys Gly Phe Tyr Gly Asn Pro Arg Thr Asn Gly Met Cys Ser Val 
             20                  25                  30
Cys Tyr Lys Glu His Leu Gln Arg Gln Asn Ser Ser Asn Gly Arg Ile 
         35                  40                  45
Ser Pro Pro Ala Ala Ser Val Ser Ser Leu Ser Glu Ser Leu Pro Val 
     50                  55                  60
Gln Cys Ala Asp Gly Ser Val Pro Asp Ala Gln Ser Ala Leu Asp Ser 
 65                  70                  75                  80
Thr Ser Ser Ser Met Gln Pro Gly Pro Val Ser Asn Gln Ser Leu Leu 
                 85                  90                  95
Ser Glu Ser Val Ala Pro Ser Gln Val Asp Ser Thr Ser Val Asp Lys 
             100                105                110
Ala Val Ser Glu Thr Glu Asp Leu Gln Gly Pro Arg Ala Glu Gly Leu 
         115                120                125
Val Pro Leu Glu Cys Asp Pro Pro Ser Ser Val Ser Asp Thr Thr Gln 
     130                135                140
Gln Pro Ser Glu Glu Gln Ser Lys Ser Leu Glu Lys Pro Lys Gln Lys 
 145                150                155                160
Lys Asn Arg Cys Phe Met Cys Arg Lys Lys Val Gly Leu Thr Gly Phe 
                 165                170                175
Glu Cys Arg Cys Gly Asn Val Tyr Cys Gly Val His Arg Tyr Ser Asp 
             180                185                190
Val His Asn Cys Ser Tyr Asn Tyr Lys Ala Asp Ala Ala Glu Lys Ile 
         195                200                205
Arg Lys Glu Asn Pro Val Val Val Gly Glu Lys Ile Gln Lys Ile 
     210                215                220



<210> 5754
<211> 1613
<212> DNA
<213> Homo sapiens
<308> AF061739
<400> 5754

cggcacgag  gcggtcgcg  cataggccg  acaaccaaa  agaaaagtt  aataaacag  60
ggacggagg  gccggcggt  gcggacgga  gcaagcagg  gttcggcgg  attacctgt  120
cccattcac  ggcggctac  ggcggcggc  cgcagcgtg  caggcggag  gacccgccg  180
cagatcaaa  gacactgac  tagctgctt  ccagaaggg  aacttgggt  tgcaactga  240
gaacatggc  caagaaact  atcacagcc  agtgcctat  ctttgttcc  ctggctgtg  300
attttatgg  aaccctcgt  caaatggca  gtgttcagt  tgctataaa  aacatcttc  360
aagacagaa  agtagtaat  gtagaataa  cccacctgt  caatgcaca  atggcagtg  420
gccagaagc  cagtcagca  tagactcta  atcttcatc  atgcagccc  gccctgtat  480
aaatcagtc  cttttatca  aatctgtag  atcttctca  ttggacagt  catctgtgg  540
caaagcagt  cctgaaaca  aagatgtgc  ggcttcagt  tcagacaca  cacagcagc  600
atctgaaga  caaagcaag  ctcttgata  ccgaaacaa  aaaagaatc  ctgtttcat  660
tgcaggaag  aagtgggac  tactgggtt  gaatgccgg  gtggaaatg  ttactgtgg  720
gtacaccgt  actcagatg  acacaattg  tcttacaat  acaaagccg  tgctgctga  780
aaaatcaga  aagaaaatc  agtagttgt  ggtgaaaag  tccaaaaga  ttgaactcc  840
gctggaata  aaaattctt  agcatctgc  aactaaaaa  tgacttgag  ttttttttt  900
cctagtcat  gggaatgta  agcagtgta  cttgcatgt  atcggaaga  tagattttt  960
ttttggttt  gttttgaaa  tgactctga  catttattt  cattgcaat  tctgtggct  1020
aggagactt  aactttaca  gtattatcc  tttaagatc  ttttaattt  agttgagtg  1080
agagggctt  tataacaaa  gtgcagaaa  tttggaggg  tgtgatttt  ccagtatta  1140
acatgcatg  attaatctt  cagtttatt  tctcattgt  tatgtatat  tcgcttttc  1200
ctgcagcac  atttctctt  tgataatgc  ctttagggc  caactagtt  tcagtaact  1260
aatgtatct  aatcattat  gctgcttct  ttttttcat  aacaaaggt  attcatatg  1320
tagcatata  tttctttgc  cccactatt  atgtctgaa  catttgtca  aagagagtg  1380
gtgcctgat  agattgtaa  tttgtgtgt  taaactttt  tttgagcga  ggaagaaaa  1440
gctgtatgc  tttcattgc  gtctacagg  ttctttcag  ttatgttca  gggtttgtg  1500
gtatacaat  tgaagaatg  tctgaagta  ttgtgctgt  tttatgttt  ttcaccagt  1560
tttgattaa  taaaaagga  aaccagaaa  aaaaaaaaa  aaaaaaaaa  aaa  1613



<210> 5755
<211> 124
<212> PRT
<213> Homo sapiens
<308> XP_044547
<400> 5755

Met Gln Pro Ser Pro Val Ser Asn Gln Ser Leu Leu Ser Glu Ser Val 
  1               5                  10                  15
Ala Ser Ser Gln Leu Asp Ser Thr Ser Val Asp Lys Ala Val Pro Glu 
             20                  25                  30
Thr Glu Asp Val Gln Ala Ser Val Ser Asp Thr Ala Gln Gln Pro Ser 
         35                  40                  45
Glu Glu Gln Ser Lys Ser Leu Glu Lys Pro Lys Gln Lys Lys Asn Arg 
     50                  55                  60
Cys Phe Met Cys Arg Lys Lys Val Gly Leu Thr Gly Phe Glu Cys Arg 
 65                  70                  75                  80
Cys Gly Asn Val Tyr Cys Gly Val His Arg Tyr Ser Asp Val His Asn 
                 85                  90                  95
Cys Ser Tyr Asn Tyr Lys Ala Asp Ala Ala Glu Lys Ile Arg Lys Glu 
             100                105                110
Asn Pro Val Val Val Gly Glu Lys Ile Gln Lys Ile 
         115                120



<210> 5756
<211> 589
<212> DNA
<213> Rattus norvegicus
<308> AA892378
<400> 5756

gcgaagcca  ggcccaact  tatttacac  cattgcaaa  catgactga  ggtaaagga  60
aggtaccag  ggatggggg  ctgggggtc  tggagactg  gcgggtgca  ggtagggtt  120
caggagaaa  ggaaggcgg  ggtgaggat  gacagcccc  ctttcagtg  cccccaggc  180
cccaggcgt  cgggggcac  gagcaggtg  ggctgcctt  aggatttgg  cttggacac  240
gccagtcca  tgagtccag  caggcccgc  acacccagg  ccatgccac  aacaatggc  300
atgcctacc  gtccatctt  cttcatggc  ttgtcaatc  ggcgttcca  ctccttggc  360
tggctgttc  ggggctcag  ctgtaacag  ccccgcaca  acttcagag  cttttcata  420
tccttgagc  ggtagttgc  cacggccag  tacaagaca  aatcccgct  ctcctcttt  480
ctacctttg  gcagcagct  ctccagcat  acgatgcct  tacggatgt  gtcattgta  540
ttgcttcga  ccaggcacc  ggcgtattc  aactgcgtg  tcttggaca  589



<210> 5757
<211> 152
<212> PRT
<213> Rattus norvegicus
<308> NP_079838
<400> 5757

Met Glu Ala Val Leu Asn Glu Leu Val Ser Val Glu Asp Leu Lys Asn 
  1               5                  10                  15
Phe Glu Arg Lys Phe Gln Ser Glu Gln Ala Ala Gly Ser Val Ser Lys 
             20                  25                  30
Ser Thr Gln Phe Glu Tyr Ala Trp Cys Leu Val Arg Ser Lys Tyr Asn 
         35                  40                  45
Glu Asp Ile Arg Arg Gly Ile Val Leu Leu Glu Glu Leu Leu Pro Lys 
     50                  55                  60
Gly Ser Lys Glu Glu Gln Arg Asp Tyr Val Phe Tyr Leu Ala Val Gly 
 65                  70                  75                  80
Asn Tyr Arg Leu Lys Glu Tyr Glu Lys Ala Leu Lys Tyr Val Arg Gly 
                 85                  90                  95
Leu Leu Gln Thr Glu Pro Gln Asn Asn Gln Ala Lys Glu Leu Glu Arg 
             100                105                110
Leu Ile Asp Lys Ala Met Lys Lys Asp Gly Leu Val Gly Met Ala Ile 
         115                120                125
Val Gly Gly Met Ala Leu Gly Val Ala Gly Leu Ala Gly Leu Ile Gly 
     130                135                140
Leu Ala Val Ser Lys Ser Lys Ser 
 145                150



<210> 5758
<211> 735
<212> DNA
<213> Homo sapiens
<308> NM_016068
<400> 5758

agtggttct  cgcccctgc  actgggcca  ggagactgt  gcacagtag  ctgtagtgt  60
aggctcgcg  gggcagtgg  catggaggc  gtgctgaac  agctggtgt  tgtggagga  120
ctgctgaag  ttgaaaaga  atttcagtc  gagaaggca  caggctcgg  gtccaagag  180
acgcagttt  agtacgcct  gtgcctggt  cggacaagg  acaatgatg  catccgtaa  240
ggcatcgtg  tgctcgagg  gctgctgcc  aaagggagc  aggaggaac  gcgggatta  300
gtcttctac  tggccgtgg  gaactaccg  ctcaaggaa  acgagaagg  cttaaagta  360
gtccgcggg  tgctgcaga  agagcccca  aacaaccag  ccaaggaac  ggagcggct  420
attgacaag  ccatgaaga  agatggact  gtgggcatg  ccatcgtgg  aggcatggc  480
ctgggtgtg  cgggactgg  cggactcat  ggacttgct  tgtccaagt  caaatcctg  540
aggagacgc  ggagcccac  gagaacgct  caggagggc  tgtccatcc  cgctgtcct  600
tccctgttc  ccccctgcc  cccgtctct  tcctctgtg  ccttcagct  atttctgct  660
ccctgagat  cgtccttca  ccccatcat  tgctttggg  tgagtgtaa  taaaacggg  720
ctgtggctt  ggaaa  735



<210> 5759
<211> 152
<212> PRT
<213> Homo sapiens
<308> AAD34130
<400> 5759

Met Glu Ala Val Leu Asn Glu Leu Val Ser Val Glu Asp Leu Leu Lys 
  1               5                  10                  15
Phe Glu Lys Lys Phe Gln Ser Glu Lys Ala Ala Gly Ser Val Ser Lys 
             20                  25                  30
Ser Thr Gln Phe Glu Tyr Ala Trp Cys Leu Val Arg Thr Arg Tyr Asn 
         35                  40                  45
Asp Asp Ile Arg Lys Gly Ile Val Leu Leu Glu Glu Leu Leu Pro Lys 
     50                  55                  60
Gly Ser Lys Glu Glu Gln Arg Asp Tyr Val Phe Tyr Leu Ala Val Gly 
 65                  70                  75                  80
Asn Tyr Arg Leu Lys Glu Tyr Glu Lys Ala Leu Lys Tyr Val Arg Gly 
                 85                  90                  95
Leu Leu Gln Thr Glu Pro Gln Asn Asn Gln Ala Lys Glu Leu Glu Arg 
             100                105                110
Leu Ile Asp Lys Ala Met Lys Lys Asp Gly Leu Val Gly Met Ala Ile 
         115                120                125
Val Gly Gly Met Ala Leu Gly Val Ala Gly Leu Ala Gly Leu Ile Gly 
     130                135                140
Leu Ala Val Ser Lys Ser Lys Ser 
 145                150



<210> 5760
<211> 589
<212> DNA
<213> Rattus norvegicus
<308> AA892378
<400> 5760

gcgaagcca  ggcccaact  tatttacac  cattgcaaa  catgactga  ggtaaagga  60
aggtaccag  ggatggggg  ctgggggtc  tggagactg  gcgggtgca  ggtagggtt  120
caggagaaa  ggaaggcgg  ggtgaggat  gacagcccc  ctttcagtg  cccccaggc  180
cccaggcgt  cgggggcac  gagcaggtg  ggctgcctt  aggatttgg  cttggacac  240
gccagtcca  tgagtccag  caggcccgc  acacccagg  ccatgccac  aacaatggc  300
atgcctacc  gtccatctt  cttcatggc  ttgtcaatc  ggcgttcca  ctccttggc  360
tggctgttc  ggggctcag  ctgtaacag  ccccgcaca  acttcagag  cttttcata  420
tccttgagc  ggtagttgc  cacggccag  tacaagaca  aatcccgct  ctcctcttt  480
ctacctttg  gcagcagct  ctccagcat  acgatgcct  tacggatgt  gtcattgta  540
ttgcttcga  ccaggcacc  ggcgtattc  aactgcgtg  tcttggaca  589



<210> 5761
<211> 735
<212> DNA
<213> Homo sapiens
<308> NM_016068
<400> 5761

agtggttct  cgcccctgc  actgggcca  ggagactgt  gcacagtag  ctgtagtgt  60
aggctcgcg  gggcagtgg  catggaggc  gtgctgaac  agctggtgt  tgtggagga  120
ctgctgaag  ttgaaaaga  atttcagtc  gagaaggca  caggctcgg  gtccaagag  180
acgcagttt  agtacgcct  gtgcctggt  cggacaagg  acaatgatg  catccgtaa  240
ggcatcgtg  tgctcgagg  gctgctgcc  aaagggagc  aggaggaac  gcgggatta  300
gtcttctac  tggccgtgg  gaactaccg  ctcaaggaa  acgagaagg  cttaaagta  360
gtccgcggg  tgctgcaga  agagcccca  aacaaccag  ccaaggaac  ggagcggct  420
attgacaag  ccatgaaga  agatggact  gtgggcatg  ccatcgtgg  aggcatggc  480
ctgggtgtg  cgggactgg  cggactcat  ggacttgct  tgtccaagt  caaatcctg  540
aggagacgc  ggagcccac  gagaacgct  caggagggc  tgtccatcc  cgctgtcct  600
tccctgttc  ccccctgcc  cccgtctct  tcctctgtg  ccttcagct  atttctgct  660
ccctgagat  cgtccttca  ccccatcat  tgctttggg  tgagtgtaa  taaaacggg  720
ctgtggctt  ggaaa  735



<210> 5762
<211> 589
<212> DNA
<213> Rattus norvegicus
<308> AA892378
<400> 5762

gcgaagcca  ggcccaact  tatttacac  cattgcaaa  catgactga  ggtaaagga  60
aggtaccag  ggatggggg  ctgggggtc  tggagactg  gcgggtgca  ggtagggtt  120
caggagaaa  ggaaggcgg  ggtgaggat  gacagcccc  ctttcagtg  cccccaggc  180
cccaggcgt  cgggggcac  gagcaggtg  ggctgcctt  aggatttgg  cttggacac  240
gccagtcca  tgagtccag  caggcccgc  acacccagg  ccatgccac  aacaatggc  300
atgcctacc  gtccatctt  cttcatggc  ttgtcaatc  ggcgttcca  ctccttggc  360
tggctgttc  ggggctcag  ctgtaacag  ccccgcaca  acttcagag  cttttcata  420
tccttgagc  ggtagttgc  cacggccag  tacaagaca  aatcccgct  ctcctcttt  480
ctacctttg  gcagcagct  ctccagcat  acgatgcct  tacggatgt  gtcattgta  540
ttgcttcga  ccaggcacc  ggcgtattc  aactgcgtg  tcttggaca  589



<210> 5763
<211> 152
<212> PRT
<213> Rattus norvegicus
<308> NP_079838
<400> 5763

Met Glu Ala Val Leu Asn Glu Leu Val Ser Val Glu Asp Leu Lys Asn 
  1               5                  10                  15
Phe Glu Arg Lys Phe Gln Ser Glu Gln Ala Ala Gly Ser Val Ser Lys 
             20                  25                  30
Ser Thr Gln Phe Glu Tyr Ala Trp Cys Leu Val Arg Ser Lys Tyr Asn 
         35                  40                  45
Glu Asp Ile Arg Arg Gly Ile Val Leu Leu Glu Glu Leu Leu Pro Lys 
     50                  55                  60
Gly Ser Lys Glu Glu Gln Arg Asp Tyr Val Phe Tyr Leu Ala Val Gly 
 65                  70                  75                  80
Asn Tyr Arg Leu Lys Glu Tyr Glu Lys Ala Leu Lys Tyr Val Arg Gly 
                 85                  90                  95
Leu Leu Gln Thr Glu Pro Gln Asn Asn Gln Ala Lys Glu Leu Glu Arg 
             100                105                110
Leu Ile Asp Lys Ala Met Lys Lys Asp Gly Leu Val Gly Met Ala Ile 
         115                120                125
Val Gly Gly Met Ala Leu Gly Val Ala Gly Leu Ala Gly Leu Ile Gly 
     130                135                140
Leu Ala Val Ser Lys Ser Lys Ser 
 145                150



<210> 5764
<211> 735
<212> DNA
<213> Homo sapiens
<308> NM_016068
<400> 5764

agtggttct  cgcccctgc  actgggcca  ggagactgt  gcacagtag  ctgtagtgt  60
aggctcgcg  gggcagtgg  catggaggc  gtgctgaac  agctggtgt  tgtggagga  120
ctgctgaag  ttgaaaaga  atttcagtc  gagaaggca  caggctcgg  gtccaagag  180
acgcagttt  agtacgcct  gtgcctggt  cggacaagg  acaatgatg  catccgtaa  240
ggcatcgtg  tgctcgagg  gctgctgcc  aaagggagc  aggaggaac  gcgggatta  300
gtcttctac  tggccgtgg  gaactaccg  ctcaaggaa  acgagaagg  cttaaagta  360
gtccgcggg  tgctgcaga  agagcccca  aacaaccag  ccaaggaac  ggagcggct  420
attgacaag  ccatgaaga  agatggact  gtgggcatg  ccatcgtgg  aggcatggc  480
ctgggtgtg  cgggactgg  cggactcat  ggacttgct  tgtccaagt  caaatcctg  540
aggagacgc  ggagcccac  gagaacgct  caggagggc  tgtccatcc  cgctgtcct  600
tccctgttc  ccccctgcc  cccgtctct  tcctctgtg  ccttcagct  atttctgct  660
ccctgagat  cgtccttca  ccccatcat  tgctttggg  tgagtgtaa  taaaacggg  720
ctgtggctt  ggaaa  735



<210> 5765
<211> 152
<212> PRT
<213> Homo sapiens
<308> AAD34130
<400> 5765

Met Glu Ala Val Leu Asn Glu Leu Val Ser Val Glu Asp Leu Leu Lys 
  1               5                  10                  15
Phe Glu Lys Lys Phe Gln Ser Glu Lys Ala Ala Gly Ser Val Ser Lys 
             20                  25                  30
Ser Thr Gln Phe Glu Tyr Ala Trp Cys Leu Val Arg Thr Arg Tyr Asn 
         35                  40                  45
Asp Asp Ile Arg Lys Gly Ile Val Leu Leu Glu Glu Leu Leu Pro Lys 
     50                  55                  60
Gly Ser Lys Glu Glu Gln Arg Asp Tyr Val Phe Tyr Leu Ala Val Gly 
 65                  70                  75                  80
Asn Tyr Arg Leu Lys Glu Tyr Glu Lys Ala Leu Lys Tyr Val Arg Gly 
                 85                  90                  95
Leu Leu Gln Thr Glu Pro Gln Asn Asn Gln Ala Lys Glu Leu Glu Arg 
             100                105                110
Leu Ile Asp Lys Ala Met Lys Lys Asp Gly Leu Val Gly Met Ala Ile 
         115                120                125
Val Gly Gly Met Ala Leu Gly Val Ala Gly Leu Ala Gly Leu Ile Gly 
     130                135                140
Leu Ala Val Ser Lys Ser Lys Ser 
 145                150



<210> 5766
<211> 589
<212> DNA
<213> Rattus norvegicus
<308> AA892378
<400> 5766

gcgaagcca  ggcccaact  tatttacac  cattgcaaa  catgactga  ggtaaagga  60
aggtaccag  ggatggggg  ctgggggtc  tggagactg  gcgggtgca  ggtagggtt  120
caggagaaa  ggaaggcgg  ggtgaggat  gacagcccc  ctttcagtg  cccccaggc  180
cccaggcgt  cgggggcac  gagcaggtg  ggctgcctt  aggatttgg  cttggacac  240
gccagtcca  tgagtccag  caggcccgc  acacccagg  ccatgccac  aacaatggc  300
atgcctacc  gtccatctt  cttcatggc  ttgtcaatc  ggcgttcca  ctccttggc  360
tggctgttc  ggggctcag  ctgtaacag  ccccgcaca  acttcagag  cttttcata  420
tccttgagc  ggtagttgc  cacggccag  tacaagaca  aatcccgct  ctcctcttt  480
ctacctttg  gcagcagct  ctccagcat  acgatgcct  tacggatgt  gtcattgta  540
ttgcttcga  ccaggcacc  ggcgtattc  aactgcgtg  tcttggaca  589



<210> 5767
<211> 735
<212> DNA
<213> Homo sapiens
<308> NM_016068
<400> 5767

agtggttct  cgcccctgc  actgggcca  ggagactgt  gcacagtag  ctgtagtgt  60
aggctcgcg  gggcagtgg  catggaggc  gtgctgaac  agctggtgt  tgtggagga  120
ctgctgaag  ttgaaaaga  atttcagtc  gagaaggca  caggctcgg  gtccaagag  180
acgcagttt  agtacgcct  gtgcctggt  cggacaagg  acaatgatg  catccgtaa  240
ggcatcgtg  tgctcgagg  gctgctgcc  aaagggagc  aggaggaac  gcgggatta  300
gtcttctac  tggccgtgg  gaactaccg  ctcaaggaa  acgagaagg  cttaaagta  360
gtccgcggg  tgctgcaga  agagcccca  aacaaccag  ccaaggaac  ggagcggct  420
attgacaag  ccatgaaga  agatggact  gtgggcatg  ccatcgtgg  aggcatggc  480
ctgggtgtg  cgggactgg  cggactcat  ggacttgct  tgtccaagt  caaatcctg  540
aggagacgc  ggagcccac  gagaacgct  caggagggc  tgtccatcc  cgctgtcct  600
tccctgttc  ccccctgcc  cccgtctct  tcctctgtg  ccttcagct  atttctgct  660
ccctgagat  cgtccttca  ccccatcat  tgctttggg  tgagtgtaa  taaaacggg  720
ctgtggctt  ggaaa  735



<210> 5768
<211> 649
<212> DNA
<213> Rattus norvegicus
<308> AA892388
<400> 5768

agataaaca  gaagtttaa  aataaaaat  agaaaaaaa  caacacagt  agctggcaa  60
aggctggca  acacagtct  acatgagac  gcctgactc  ttatggatt  ttgtaaagt  120
acaggattg  tccctcact  tagagagtc  ttactctga  agggtaggc  tgtcttcct  180
gtatggctg  tacaccagt  ggttctgta  tctgtcacc  tgtgaggaa  gctgcctaa  240
tctgacctt  aacctgtgg  aaaaacaac  acaacaaca  caaccacga  attccttga  300
atccatttc  tcagtccac  cccattccc  gcttctgag  ttagcagac  gatgaaagc  360
agttttctg  agaactaag  gcttgagga  tgctggagg  tccccacca  gagatagcc  420
caactccca  ggtctcctg  aagttctga  tcctgcaga  tcctctctc  tgcaaagtg  480
tcaggaaca  aaaatgtct  gatcctggt  acaagcagg  gccggatca  ttaggaggt  540
ctgctcctc  tccgggggt  aagggcttt  ctcctggca  tgttctcct  cgtgtcact  600
tcgcagttc  tcaggtcct  acttgtcct  aagtgcacc  tcttcatca  649



<210> 5769
<211> 126
<212> PRT
<213> Rattus norvegicus
<308> P27274
<400> 5769

Met Arg Ala Arg Arg Gly Phe Ile Leu Leu Leu Leu Leu Ala Val Leu 
  1               5                  10                  15
Cys Ser Thr Gly Val Ser Leu Arg Cys Tyr Asn Cys Leu Asp Pro Val 
             20                  25                  30
Ser Ser Cys Lys Thr Asn Ser Thr Cys Ser Pro Asn Leu Asp Ala Cys 
         35                  40                  45
Leu Val Ala Val Ser Gly Lys Gln Val Tyr Gln Gln Cys Trp Arg Phe 
     50                  55                  60
Ser Asp Cys Asn Ala Lys Phe Ile Leu Ser Arg Leu Glu Ile Ala Asn 
 65                  70                  75                  80
Val Gln Tyr Arg Cys Cys Gln Ala Asp Leu Cys Asn Lys Ser Phe Glu 
                 85                  90                  95
Asp Lys Pro Asn Asn Gly Ala Ile Ser Leu Leu Gly Lys Thr Ala Leu 
             100                105                110
Leu Val Thr Ser Val Leu Ala Ala Ile Leu Lys Pro Cys Phe 
         115                120                125



<210> 5770
<211> 1742
<212> DNA
<213> Homo sapiens
<308> AF052941
<400> 5770

gaccgcggc  gctcagcct  ccgccgatt  tatgttcca  gcctcaatg  ggagtccaa  60
catggagcc  ttcaagcag  agaaggtgg  ggactttta  gacatcgga  aggagctgg  120
gagtggcca  tttgccatc  tgaagaagt  ccgggagaa  agcacgggg  ttgagtatg  180
agccaagtt  atcaagaag  ggcagagcc  ggcgagccg  cgcggtgtg  gccgggagg  240
gatcgagcg  gaggtgagc  tcctgcggc  ggtgctgca  cacaatgtc  tcacgctgc  300
cgacgtcta  gagaaccgc  ccgacgtgg  gctcatcct  gagctagtg  ctggaggag  360
gctcttcga  ttcctggcc  agaaggagt  actgagtga  gaggaggcc  ccagcttca  420
taagcagat  ctggatggg  tgaactacc  tcacacaaa  aaaattgct  actttgatc  480
caagccaga  aacattatg  tgttagaca  gaatattcc  attccacac  tcaagctga  540
tgactttgg  ctggctcac  aaatagaag  tggagttga  tttaagaat  tttttggga  600
gccggaatt  gttgctcca  aaattgtga  ctacgagcc  ctgggtctg  aggctgaca  660
gtggagcat  ggcgtcatc  cctacatcc  cttaagtgg  gcatcccct  tcctgggag  720
cacgaagca  gaaacactg  caaatatca  atcagtgag  tacgacttt  atgaggaat  780
cttcagcca  acgagcgag  tggccaagg  ctttattcg  aagcttctg  ttaaagaga  840
ccggaaacg  ctcacaatc  aagaggctc  cagacaccc  tggatcacg  cggtggaca  900
ccagcaagc  atggtgcgc  gggagtctg  ggtcaatct  gagaacttc  ggaagcagt  960
tgtccgcag  cggtggaag  tttccttca  catcgtgtc  ctgtgcaac  acctcaccc  1020
ctcgctgat  aagaaggtg  acctgaggc  ggatgagga  ctgaggaac  gtgagagtg  1080
cactgagga  gacatcgcc  ggaggaaag  cctccaccc  cggaggagg  gcagcacct  1140
ctaactggc  tgacctgca  tggccgcca  ggaggtttg  gcccagcgg  gctcccttc  1200
gtgcagact  ttggaccca  ctcagcacc  gcacccggg  gtcctgagc  ctttgcaag  1260
gagatgggc  caaggaatt  agaagagct  gcaggcaag  caggagacc  tgggagctg  1320
ggctgtctt  tgtggagga  gctccagca  tcccaaagc  cttaattct  cataaaatg  1380
gctttcctc  gtctgccat  ctcagagtc  ggggtggga  tgtggactt  ggaaaacaa  1440
ataaaggac  tcctcatca  cacggggtg  aggtcagag  aaggcagcc  tcttcacag  1500
ctgaggggg  tcagaacca  cctggccaa  aattacacc  gagagacag  gtcctcccc  1560
ttgggaaca  ggtgattga  gaaagtgaa  cttgggtgt  agggaccaa  cctgtgacc  1620
cccagaacc  tggaagcca  gacgtcagg  tgaccaaca  ctcagacct  ctgaagcag  1680
ccattgctg  cccgccatg  tgtaatttt  ctcattttt  ttaaacttc  ggtttacct  1740
aa  1742



<210> 5771
<211> 370
<212> PRT
<213> Homo sapiens
<308> NP_055141
<400> 5771

Met Phe Gln Ala Ser Met Arg Ser Pro Asn Met Glu Pro Phe Lys Gln 
  1               5                  10                  15
Gln Lys Val Glu Asp Phe Tyr Asp Ile Gly Glu Glu Leu Gly Ser Gly 
             20                  25                  30
Gln Phe Ala Ile Val Lys Lys Cys Arg Glu Lys Ser Thr Gly Leu Glu 
         35                  40                  45
Tyr Ala Ala Lys Phe Ile Lys Lys Arg Gln Ser Arg Ala Ser Arg Arg 
     50                  55                  60
Gly Val Ser Arg Glu Glu Ile Glu Arg Glu Val Ser Ile Leu Arg Gln 
 65                  70                  75                  80
Val Leu His His Asn Val Ile Thr Leu His Asp Val Tyr Glu Asn Arg 
                 85                  90                  95
Thr Asp Val Val Leu Ile Leu Glu Leu Val Ser Gly Gly Glu Leu Phe 
             100                105                110
Asp Phe Leu Ala Gln Lys Glu Ser Leu Ser Glu Glu Glu Ala Thr Ser 
         115                120                125
Phe Ile Lys Gln Ile Leu Asp Gly Val Asn Tyr Leu His Thr Lys Lys 
     130                135                140
Ile Ala His Phe Asp Leu Lys Pro Glu Asn Ile Met Leu Leu Asp Lys 
 145                150                155                160
Asn Ile Pro Ile Pro His Ile Lys Leu Ile Asp Phe Gly Leu Ala His 
                 165                170                175
Glu Ile Glu Asp Gly Val Glu Phe Lys Asn Ile Phe Gly Thr Pro Glu 
             180                185                190
Phe Val Ala Pro Glu Ile Val Asn Tyr Glu Pro Leu Gly Leu Glu Ala 
         195                200                205
Asp Met Trp Ser Ile Gly Val Ile Thr Tyr Ile Leu Leu Ser Gly Ala 
     210                215                220
Ser Pro Phe Leu Gly Asp Thr Lys Gln Glu Thr Leu Ala Asn Ile Thr 
 225                230                235                240
Ala Val Ser Tyr Asp Phe Asp Glu Glu Phe Phe Ser Gln Thr Ser Glu 
                 245                250                255
Leu Ala Lys Asp Phe Ile Arg Lys Leu Leu Val Lys Glu Thr Arg Lys 
             260                265                270
Arg Leu Thr Ile Gln Glu Ala Leu Arg His Pro Trp Ile Thr Pro Val 
         275                280                285
Asp Asn Gln Gln Ala Met Val Arg Arg Glu Ser Val Val Asn Leu Glu 
     290                295                300
Asn Phe Arg Lys Gln Tyr Val Arg Arg Arg Trp Lys Leu Ser Phe Ser 
 305                310                315                320
Ile Val Ser Leu Cys Asn His Leu Thr Arg Ser Leu Met Lys Lys Val 
                 325                330                335
His Leu Arg Pro Asp Glu Asp Leu Arg Asn Cys Glu Ser Asp Thr Glu 
             340                345                350
Glu Asp Ile Ala Arg Arg Lys Ala Leu His Pro Arg Arg Arg Ser Ser 
         355                360                365
Thr Ser 
     370



<210> 5772
<211> 609
<212> DNA
<213> Rattus norvegicus
<308> AA892394
<400> 5772

caaacagtt  aatagcaaa  aaacaaagg  aggtaccac  cttggcaga  acaaaatga  60
tttttgtcc  tgtgtctgt  caattaaaa  agatttagg  tccccattg  gacaaaagg  120
aaaacacac  aaaagggag  gtcctttta  acacacact  ccttgctcc  aacttttaa  180
aacttttcc  tttttaatc  actacacaa  ctgtgatta  gtaagaaaa  cgacaaggg  240
tcttcttgc  ctttttttt  ttttaaaaa  cattaaagc  aaatccata  ttttctaca  300
agtacaaca  aagttcaca  acaaaagac  tcttttata  atcaaacag  aaaaaagga  360
agctcaaac  aggtcaaga  gaaagcatc  ctacggctg  atcacgact  tgagttgat  420
gaatcccgt  gctgctgca  aacagactg  gcgtttggt  atagtggca  ttttttctc  480
tcacattgt  aaatcactt  acattgttt  ctagtagaa  aggcaaaaa  ctgtacaaa  540
cccctagtg  taaatacaa  gtttgtacc  ataaaaaac  cacacaggt  tgtctccaa  600
atgtaaagt  609



<210> 5773
<211> 1884
<212> DNA
<213> Homo sapiens
<308> AK057016
<400> 5773

tcttctgag  tctcaactg  ggagagcac  tgaaccccc  ttccttttt  accgcaggc  60
gcactttgg  ccccagcca  ccctttttc  ttttctttt  cttttgtgg  tcttccctg  120
agcgactct  gggagtcct  gatatcccg  ctgcccctt  ccctcagcc  catgcttgt  180
ccaacagtc  ccacagcaa  atgtgatgc  ttgattttt  tgttgttgt  tttgttttt  240
tattgtttt  gtgtttttg  tttgaattt  ttcctttcc  actaagatt  tgcccagaa  300
aaagttttg  atgtttcct  ctgtttctt  acaccttcg  atatatcac  ttcacctct  360
tgttttcta  agtttgtgc  aaaactgat  gatttaaaa  ggtttcaaa  aagctgttt  420
aaattgttg  agggttgat  atttttttc  agattgtat  gtttaattt  gaagtggca  480
ctttctcct  tattgccct  agagcgttt  cctgtgcac  tagactgtc  cttcgtgtg  540
cctccaggt  ttaccgggg  ttccgggag  ctggctgct  tgctcagag  gggtgggaa  600
ggggcctgg  gagacacga  aagcagagg  agagcctag  aggtggcag  aggtgggta  660
gaggcttat  tagcacatt  ggggcagtg  gcacctgga  gaaggaggg  gctcccaat  720
acccgtagg  ggccatctg  acaccaagc  gcaattcac  tgctggcgc  tttcctagg  780
gacaagcac  atactacag  cttcacact  tttacagcc  tgggcacca  ccacccggc  840
ctggctctt  atcacagct  tgctcttgc  tagctagtg  ggtggggga  agggcaggg  900
tttgttttt  taattgggt  gagagccaa  cagctactg  ccctgggtg  caagcaagc  960
agttttttg  ttccctgag  gaaactgac  ctcctctct  gtggcacca  ccagcctca  1020
ggtcttgga  acttgagta  gaatgtgag  ggaggggga  aggtgagga  aggagcaca  1080
ggtggatct  tggagggaa  aggttacag  gggaggagc  gatgataga  cccacccag  1140
cttaagctg  tggtgggtg  gtgagctgg  aagtaggac  gtccaggga  gggtggaga  1200
atgtagcta  gggctgggg  gggggaggt  gaagcgcta  tgagcatcc  ccacaccaa  1260
gttgatgaa  gaagggatc  cagcagggt  tctgctctg  ggctggcag  ttgcctggt  1320
ttatgccca  ggccgctct  cctggggga  agggcagcc  ggcagaggc  cagtgtctg  1380
taggctgct  aatttcctg  aaggggtga  tggatggaa  gaggccaga  accccagcc  1440
gagagactg  tgtgcaccc  acagtctga  tgcacagag  cgcctctgt  ggcaggagg  1500
actgaggct  cccttcctg  gtattgaga  gcagtgttt  ccaatatat  ttgctttca  1560
ttccaagag  agctctggg  aaacctgtg  ataaaacca  gccaatgtt  gacgttgtt  1620
ccttttcct  ttctctctc  gattgtttt  attgttctg  ggtggtttt  atggatttg  1680
gaccctgga  cggcagctg  ctttctgat  tccagctgc  ttttgtgaa  aatttaaaa  1740
gaaaaaaaa  aaagaaact  tacattttg  agacaaacc  gtgtgagtt  tttattggt  1800
caaacgttg  atttaacac  aggggtttt  tacagtttt  tgccttttc  actagaaaa  1860
aatgtaaag  gatttcaca  tgtg  1884



<210> 5774
<211> 609
<212> DNA
<213> Rattus norvegicus
<308> AA892394
<400> 5774

caaacagtt  aatagcaaa  aaacaaagg  aggtaccac  cttggcaga  acaaaatga  60
tttttgtcc  tgtgtctgt  caattaaaa  agatttagg  tccccattg  gacaaaagg  120
aaaacacac  aaaagggag  gtcctttta  acacacact  ccttgctcc  aacttttaa  180
aacttttcc  tttttaatc  actacacaa  ctgtgatta  gtaagaaaa  cgacaaggg  240
tcttcttgc  ctttttttt  ttttaaaaa  cattaaagc  aaatccata  ttttctaca  300
agtacaaca  aagttcaca  acaaaagac  tcttttata  atcaaacag  aaaaaagga  360
agctcaaac  aggtcaaga  gaaagcatc  ctacggctg  atcacgact  tgagttgat  420
gaatcccgt  gctgctgca  aacagactg  gcgtttggt  atagtggca  ttttttctc  480
tcacattgt  aaatcactt  acattgttt  ctagtagaa  aggcaaaaa  ctgtacaaa  540
cccctagtg  taaatacaa  gtttgtacc  ataaaaaac  cacacaggt  tgtctccaa  600
atgtaaagt  609



<210> 5775
<211> 1884
<212> DNA
<213> Homo sapiens
<308> AK057016
<400> 5775

tcttctgag  tctcaactg  ggagagcac  tgaaccccc  ttccttttt  accgcaggc  60
gcactttgg  ccccagcca  ccctttttc  ttttctttt  cttttgtgg  tcttccctg  120
agcgactct  gggagtcct  gatatcccg  ctgcccctt  ccctcagcc  catgcttgt  180
ccaacagtc  ccacagcaa  atgtgatgc  ttgattttt  tgttgttgt  tttgttttt  240
tattgtttt  gtgtttttg  tttgaattt  ttcctttcc  actaagatt  tgcccagaa  300
aaagttttg  atgtttcct  ctgtttctt  acaccttcg  atatatcac  ttcacctct  360
tgttttcta  agtttgtgc  aaaactgat  gatttaaaa  ggtttcaaa  aagctgttt  420
aaattgttg  agggttgat  atttttttc  agattgtat  gtttaattt  gaagtggca  480
ctttctcct  tattgccct  agagcgttt  cctgtgcac  tagactgtc  cttcgtgtg  540
cctccaggt  ttaccgggg  ttccgggag  ctggctgct  tgctcagag  gggtgggaa  600
ggggcctgg  gagacacga  aagcagagg  agagcctag  aggtggcag  aggtgggta  660
gaggcttat  tagcacatt  ggggcagtg  gcacctgga  gaaggaggg  gctcccaat  720
acccgtagg  ggccatctg  acaccaagc  gcaattcac  tgctggcgc  tttcctagg  780
gacaagcac  atactacag  cttcacact  tttacagcc  tgggcacca  ccacccggc  840
ctggctctt  atcacagct  tgctcttgc  tagctagtg  ggtggggga  agggcaggg  900
tttgttttt  taattgggt  gagagccaa  cagctactg  ccctgggtg  caagcaagc  960
agttttttg  ttccctgag  gaaactgac  ctcctctct  gtggcacca  ccagcctca  1020
ggtcttgga  acttgagta  gaatgtgag  ggaggggga  aggtgagga  aggagcaca  1080
ggtggatct  tggagggaa  aggttacag  gggaggagc  gatgataga  cccacccag  1140
cttaagctg  tggtgggtg  gtgagctgg  aagtaggac  gtccaggga  gggtggaga  1200
atgtagcta  gggctgggg  gggggaggt  gaagcgcta  tgagcatcc  ccacaccaa  1260
gttgatgaa  gaagggatc  cagcagggt  tctgctctg  ggctggcag  ttgcctggt  1320
ttatgccca  ggccgctct  cctggggga  agggcagcc  ggcagaggc  cagtgtctg  1380
taggctgct  aatttcctg  aaggggtga  tggatggaa  gaggccaga  accccagcc  1440
gagagactg  tgtgcaccc  acagtctga  tgcacagag  cgcctctgt  ggcaggagg  1500
actgaggct  cccttcctg  gtattgaga  gcagtgttt  ccaatatat  ttgctttca  1560
ttccaagag  agctctggg  aaacctgtg  ataaaacca  gccaatgtt  gacgttgtt  1620
ccttttcct  ttctctctc  gattgtttt  attgttctg  ggtggtttt  atggatttg  1680
gaccctgga  cggcagctg  ctttctgat  tccagctgc  ttttgtgaa  aatttaaaa  1740
gaaaaaaaa  aaagaaact  tacattttg  agacaaacc  gtgtgagtt  tttattggt  1800
caaacgttg  atttaacac  aggggtttt  tacagtttt  tgccttttc  actagaaaa  1860
aatgtaaag  gatttcaca  tgtg  1884



<210> 5776
<211> 393
<212> DNA
<213> Rattus norvegicus
<308> AA892400
<400> 5776

aaggatgga  actgtttat  tatgggtaa  gaatagctg  gagaacact  gaatttgat  60
aagctgtgc  actttgcag  tcgggttgg  ttatcatca  aaggtccaa  ataaaagtt  120
cttcacaga  aggaggagg  agcaataag  taatgcata  taagcgctt  tacaagcat  180
ctttatagg  aggagattc  taattatag  caatatatt  tagacagta  ctttgacta  240
ttcacaaga  cataaaatt  ctgagtatg  aatgggtgc  gacacgacc  tgacgaaga  300
ggcatatgt  gtgtacctg  catgatcac  gctcctaag  tttgaacta  attttgctg  360
gggacacaa  aacataaga  tttctctag  agt  393



<210> 5777
<211> 393
<212> DNA
<213> Rattus norvegicus
<308> AA892400
<400> 5777

aaggatgga  actgtttat  tatgggtaa  gaatagctg  gagaacact  gaatttgat  60
aagctgtgc  actttgcag  tcgggttgg  ttatcatca  aaggtccaa  ataaaagtt  120
cttcacaga  aggaggagg  agcaataag  taatgcata  taagcgctt  tacaagcat  180
ctttatagg  aggagattc  taattatag  caatatatt  tagacagta  ctttgacta  240
ttcacaaga  cataaaatt  ctgagtatg  aatgggtgc  gacacgacc  tgacgaaga  300
ggcatatgt  gtgtacctg  catgatcac  gctcctaag  tttgaacta  attttgctg  360
gggacacaa  aacataaga  tttctctag  agt  393



<210> 5778
<211> 448
<212> DNA
<213> Rattus norvegicus
<308> AA892414
<400> 5778

caataacat  tacaaaaaa  agttttctc  aacaattag  aaacaaatg  gaaaggcag  60
atggttcac  ttatagact  aggtagaga  ttgtacttc  tatagatga  aaataccag  120
tctacaatt  gtttaattg  ctttggatt  tattacaaa  gaaaatacg  ttgcaatta  180
aaatgtcat  aaaattgta  ctgtattga  aagttacac  aaagtatca  atattatat  240
aatggacaa  aaatttaaa  tttaattta  gcttaacat  gtaaacact  gaagacacc  300
tacccctac  atgccaaat  tcttaaagg  atacaagaa  agctacagt  cagaaacaa  360
gaatgtgca  aaaatatga  tagagacca  agagctggg  tttacactc  aactacata  420
agttaaaaa  ttaaaataa  ctttacat  448



<210> 5779
<211> 1241
<212> PRT
<213> Rattus norvegicus
<308> AAF14345
<400> 5779

Met Glu Ala Asp Gly Ala Gly Glu Gln Met Arg Pro Leu Leu Thr Arg 
  1               5                  10                  15
Gly Pro Asp Glu Glu Ala Val Val Asp Leu Gly Lys Thr Ser Ser Thr 
             20                  25                  30
Val Asn Thr Lys Phe Glu Lys Glu Glu Leu Glu Ser His Arg Ala Val 
         35                  40                  45
Tyr Val Gly Val His Val Pro Phe Ser Lys Glu Ser Arg Arg Arg His 
     50                  55                  60
Arg His Arg Gly His Lys His His His Arg Arg Arg Lys Asp Lys Asp 
 65                  70                  75                  80
Ser Asp Lys Glu Asp Gly Arg Glu Ser Pro Ser Tyr Asp Thr Pro Ser 
                 85                  90                  95
Gln Arg Val Gln Phe Ile Leu Gly Thr Glu Asp Asp Asp Glu Glu His 
             100                105                110
Ile Pro His Asp Leu Phe Thr Glu Met Asp Glu Leu Cys Tyr Arg Asp 
         115                120                125
Gly Glu Glu Tyr Glu Trp Lys Glu Thr Ala Arg Trp Leu Lys Phe Glu 
     130                135                140
Glu Asp Val Glu Asp Gly Gly Asp Arg Trp Ser Lys Pro Tyr Val Ala 
 145                150                155                160
Thr Leu Ser Leu His Ser Leu Phe Glu Leu Arg Ser Cys Ile Leu Asn 
                 165                170                175
Gly Thr Val Met Leu Asp Met Arg Ala Ser Thr Leu Asp Glu Ile Ala 
             180                185                190
Asp Met Val Leu Asp Asn Met Ile Ala Ser Gly Gln Leu Asp Asp Ser 
         195                200                205
Ile Arg Glu Asn Val Arg Glu Ala Leu Leu Lys Arg His His His Gln 
     210                215                220
Asn Glu Lys Arg Phe Thr Ser Arg Ile Pro Leu Val Arg Ser Phe Ala 
 225                230                235                240
Asp Ile Gly Lys Gly Leu Ser Ala Ser Arg His Ser Leu Arg Thr Gly 
                 245                250                255
Leu Ser Ala Ser Asn Leu Ser Leu Arg Gly Glu Ser Pro Leu Ser Leu 
             260                265                270
Leu Leu Ser His Leu Leu Pro Ser Ser Arg Ala Gly Thr Pro Ala Gly 
         275                280                285
Ser Arg Cys Thr Thr Pro Val Pro Thr Pro Gln Asn Ser Pro Pro Ser 
     290                295                300
Ser Pro Ser Leu Ser Arg Leu Thr Ser Arg Ser Ser Gln Gln Thr Gln 
 305                310                315                320
Pro Gln Ala Pro Glu Val Leu Val Ser Pro Asp Arg Asp Asp Ile Pro 
                 325                330                335
Arg Val Val Ile His Pro Pro Glu Glu Asp Ile Glu Ala Leu Lys Gly 
             340                345                350
Gln Glu Gln Lys Asn Glu Glu Asn Thr Asp Phe Thr Pro Gly Ile Leu 
         355                360                365
Ala Ser Pro Gln Ser Ala Pro Gly Asn Leu Asp Ser Ser Lys Ser Gly 
     370                375                380
Glu Val Lys Gly Asn Gly Ser Gly Gly Ser Arg Glu Asn Ser Thr Val 
 385                390                395                400
Asp Phe Ser Lys Val Asp Met Asn Phe Met Arg Lys Ile Pro Thr Gly 
                 405                410                415
Ala Glu Ala Ser Asn Val Leu Val Gly Glu Val Asp Phe Leu Glu Arg 
             420                425                430
Pro Ile Ile Ala Phe Val Arg Leu Ala Pro Ala Val Leu Leu Ser Gly 
         435                440                445
Leu Thr Glu Val Pro Val Pro Thr Arg Phe Leu Phe Leu Leu Leu Gly 
     450                455                460
Pro Ala Gly Lys Ala Pro Gln Tyr His Glu Ile Gly Arg Ser Ile Ala 
 465                470                475                480
Thr Leu Met Thr Asp Glu Ile Phe His Asp Val Ala Tyr Lys Ala Lys 
                 485                490                495
Asp Arg Asn Asp Leu Leu Ser Gly Ile Asp Glu Phe Leu Asp Gln Val 
             500                505                510
Thr Val Leu Pro Pro Gly Glu Trp Asp Pro Ser Ile Arg Ile Glu Pro 
         515                520                525
Pro Lys Ser Val Pro Ser Gln Glu Lys Arg Lys Ile Pro Ala Phe Pro 
     530                535                540
Asn Gly Ser Ala Pro Val Ser Ala Asp Pro Pro Lys Glu Ala Asp His 
 545                550                555                560
His Ala Gly Pro Glu Leu Gln Arg Thr Gly Arg Leu Phe Gly Gly Leu 
                 565                570                575
Ile Leu Asp Ile Lys Arg Lys Ala Pro Phe Phe Leu Ser Asp Phe Lys 
             580                585                590
Asp Ala Leu Ser Leu Gln Cys Leu Ala Ser Ile Leu Phe Leu Tyr Cys 
         595                600                605
Ala Cys Met Ser Pro Val Ile Thr Phe Gly Gly Leu Leu Gly Glu Ala 
     610                615                620
Thr Glu Gly Arg Ile Ser Ala Ile Glu Ser Leu Phe Gly Ala Ser Leu 
 625                630                635                640
Thr Gly Ile Ala Tyr Ser Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu 
                 645                650                655
Gly Ser Thr Gly Pro Val Leu Val Phe Glu Lys Ile Leu Phe Lys Phe 
             660                665                670
Cys Arg Asp Tyr His Leu Ser Tyr Leu Ser Leu Arg Thr Ser Ile Gly 
         675                680                685
Leu Trp Thr Ser Phe Leu Cys Ile Val Leu Val Ala Thr Asp Ala Ser 
     690                695                700
Ser Leu Val Cys Tyr Ile Thr Arg Phe Thr Glu Glu Ala Phe Ala Ala 
 705                710                715                720
Leu Ile Cys Ile Ile Phe Ile Tyr Glu Ala Leu Glu Lys Leu Phe His 
                 725                730                735
Leu Gly Glu Ile Tyr Ala Phe Asn Met His Asn Asn Leu Asp Ala Leu 
             740                745                750
Thr Ser Tyr Thr Cys Val Cys Ala Glu Pro Ser Asn Pro Ser Asn Glu 
         755                760                765
Thr Val Glu Leu Trp Glu Arg Lys Asn Val Thr Ala Ala Ser Ile Ser 
     770                775                780
Trp Ala Asn Leu Thr Val Ser Glu Cys Lys Thr Phe His Gly Met Phe 
 785                790                795                800
Val Gly Ser Ala Cys Gly Pro His Gly Pro Tyr Val Pro Asp Val Leu 
                 805                810                815
Phe Trp Cys Val Val Leu Phe Phe Thr Thr Phe Phe Leu Ser Ser Phe 
             820                825                830
Leu Lys Gln Phe Lys Thr Lys Arg Tyr Phe Pro Thr Lys Val Arg Ser 
         835                840                845
Thr Ile Ser Asp Phe Ala Val Phe Leu Thr Ile Val Ile Met Val Ala 
     850                855                860
Ile Asp Tyr Leu Val Gly Ile Pro Ser Pro Lys Leu His Val Pro Glu 
 865                870                875                880
Lys Phe Glu Pro Thr Asp Pro Ser Arg Gly Trp Ile Ile Ser Pro Leu 
                 885                890                895
Gly Asp Asn Pro Trp Trp Thr Leu Leu Ile Ala Ala Val Pro Ala Leu 
             900                905                910
Leu Cys Thr Ile Leu Ile Phe Met Asp Gln Gln Ile Thr Ala Val Ile 
         915                920                925
Ile Asn Arg Lys Glu His Lys Leu Lys Lys Gly Ala Gly Tyr His Leu 
     930                935                940
Asp Leu Leu Met Val Ala Val Met Leu Gly Val Cys Ser Ile Met Gly 
 945                950                955                960
Leu Pro Trp Phe Val Ala Ala Thr Val Leu Ser Ile Ser His Val Asn 
                 965                970                975
Ser Leu Lys Val Glu Ser Glu Cys Ser Ala Pro Gly Glu Gln Pro Lys 
             980                985                990
Phe Leu Gly Ile Arg Glu Gln Arg Val Thr Gly Leu Met Ile Phe Ile 
         995                1000                1005
Leu Met Gly Leu Ser Val Phe Met Thr Ser Val Leu Lys Phe Ile Pro 
     1010                1015                1020
Met Pro Val Leu Tyr Gly Val Phe Leu Tyr Met Gly Val Ser Ser Leu 
 1025                1030                1035                1040
Lys Gly Ile Gln Phe Phe Asp Arg Ile Lys Leu Phe Gly Met Pro Ala 
                 1045                1050                1055
Lys His Gln Pro Asp Leu Ile Tyr Leu Arg Tyr Val Pro Leu Trp Lys 
             1060                1065                1070
Val His Val Phe Thr Val Val Gln Leu Thr Cys Leu Val Leu Leu Trp 
         1075                1080                1085
Val Ile Lys Ala Ser Ala Ala Ala Val Val Phe Pro Met Met Val Leu 
     1090                1095                1100
Ala Leu Val Phe Val Arg Lys Leu Met Asp Leu Cys Phe Thr Lys Arg 
 1105                1110                1115                1120
Glu Leu Ser Trp Leu Asp Asp Leu Met Pro Glu Ser Lys Lys Lys Lys 
                 1125                1130                1135
Glu Asp Asp Lys Lys Lys Lys Glu Lys Glu Glu Ala Glu Arg Met Leu 
             1140                1145                1150
Gln Gly Asp Gly Asp Thr Val His Leu Pro Phe Glu Arg Gly Ser Leu 
         1155                1160                1165
Leu Gln Ile Pro Val Lys Thr Leu Lys Tyr Ser Ile Asp Pro Ser Val 
     1170                1175                1180
Val Asn Ile Ser Asp Glu Met Ala Lys Thr Ala Gln Trp Lys Ala Leu 
 1185                1190                1195                1200
Ser Met Asn Thr Glu Asn Ala Lys Val Thr Arg Pro Asn Met Ser Pro 
                 1205                1210                1215
Glu Lys Pro Val Ser Val Thr Ile Asn Phe Glu Asp Glu Pro Ser Lys 
             1220                1225                1230
Lys Tyr Met Asp Ala Glu Thr Ser Leu 
         1235                1240



<210> 5780
<211> 7785
<212> DNA
<213> Homo sapiens
<308> AF047033
<400> 5780

ctcactgtc  ctggaatct  caagggagt  actgcatta  atcatcaga  acaaggcat  60
tctatatta  tatggaaag  tttcgtctg  agaagaagt  acctggtcc  gatgaagaa  120
ctgttgtgg  tcttggcaa  actagctca  ctgtgaaca  caagtttga  aaagaagaa  180
tagaaagtc  tagagctgt  tatattggt  ttcacgtcc  gtttagtaa  gagagtcgt  240
ggcgtcata  gcatcgcgg  cacaaacat  accaccgga  gagaaaaga  aaagaatca  300
ataaagaag  tggacggga  tctccttct  atgatacac  atcccagag  gttcagttt  360
tccttggta  tgaagatga  gatgaagaa  atattcccc  tgatctctt  acggaaatg  420
atgaactgt  ttacagaga  ggagaagaa  atgaatgga  agaaactgc  agatggctg  480
aatttgaag  ggatgttga  gatggcggt  accgatgga  taaacctta  gtggcaact  540
tctctttgc  cagtctttt  gaactaagg  gttgcatcc  caatggaac  gtcatgctg  600
atatgagag  aagcactct  gatgaaata  cagatatgg  attagacaa  atgatagct  660
ctggccaat  agacgagtc  atacgagag  atgtcagag  agctcttct  aagagacat  720
atcatcaga  tgagaaaag  ttcaccagt  ggattcctc  tgttcgatc  tttgcagat  780
taggcaaga  acattctga  cctcacttg  ttgaaagga  tggggaagg  ctttcagcc  840
cccgccact  tttgcgaac  ggtctgtct  cctcaaacc  ttccttgag  ggagaatca  900
ctttatctc  tcttctcgg  catcttctt  cttcttcaa  agctggaac  cctgcaggc  960
caaggtgta  aaccccagt  cccacccct  aaaacagtc  tccttctag  cctagcatc  1020
gccgcctga  ctccagaag  tcccaaaag  gtcagcgtc  ggccccaga  ctactggtt  1080
cacctgcca  tgatgatat  cccacagta  taattcatc  gcctgagga  gacttagaa  1140
cagcgctga  aggcgagga  cagaagaat  aggaaaatg  tgacttaac  ccaggtatt  1200
tggcctctc  ccagtctgc  cctggaaac  tggacaata  taaaagtgg  gaaattaaa  1260
gtaatggaa  tggtggaag  agagaaaat  gtactgttg  cttcagcaa  gttgatatg  1320
atttcatga  aaaaattcc  acgggtgct  aggcatcca  cgtcctggt  ggcgaagta  1380
actttttgg  aaggccaat  attgcattt  tgagactgg  tcctgctgt  ctccttaca  1440
ggttgactg  ggtccctgt  ccaaccagg  ttttgtttt  gttattggg  ccagcgggc  1500
aggcaccac  gtaccatga  attggacga  caatagcca  tctcatgac  gatgagatt  1560
tccatgatg  agcttataa  gcaaaagac  gaaatgacc  cttatctgg  attgatgaa  1620
ttttagatc  agtaactgt  ctacctcca  gagagtggg  tccttctat  cgcatagaa  1680
caccaaaaa  tgtcccttc  caggaaaag  gaaagattc  tgtgtttca  aatggatct  1740
cccccacac  gggtgagac  cctaaagag  ccgctcatc  tgctgggcc  gagctacag  1800
ggactggac  gctttttgg  ggtttgata  ttgacatca  aaggaaagc  ccttttttc  1860
tgagtgact  caaggatgc  ttaagcctg  agtgcctgg  ctcgattct  ttcctatac  1920
gtgcctgta  gtctcctgt  atcactttt  gagggctgc  tggagaagc  acagaaggc  1980
gaataagtg  aatagagtc  ctttttgga  catcattaa  tgggattgc  tattcattg  2040
ttgctgggc  acctctaac  atattgggg  gcacaggtc  agttctagt  tttgaaaaa  2100
ttttatata  attctgcag  gattatcaa  tttcttatc  gtctttaag  accagtatt  2160
gtctgtgga  ttctttttt  tgcattgtt  tggttgcaa  agatgcaag  agccttgtg  2220
gttatatta  tcgatttac  gaagaggct  ttgcagccc  tatttgcat  atattcatc  2280
acgaggctt  ggagaagct  tttgattta  gagaaacat  tgcatttaa  atgcacaac  2340
acttagata  actgaccag  tactcatgt  tatgtactg  acctccaaa  cccagcaat  2400
aaactctag  acaatggaa  aaagataat  taacagcac  caatatttc  tggagaaat  2460
ttactgttt  tgaatgtaa  aaacttcgt  gtgtattct  ggggtcagc  tgtggtcat  2520
atggacctt  tattccaga  gtgctcttt  ggtgtgtca  cttgttttt  acaacattt  2580
ttctgtctt  attcctcaa  caatttaag  ccaagcgtt  ctttcctac  aaggtgcga  2640
cgacaatca  tgattttgc  gtatttctc  caatagtaa  aatggttac  attgactac  2700
ttgtaggag  tccatctcc  aaacttcat  ttcctgaaa  atttgagcc  actcatcca  2760
agagagggt  gatcataag  ccactggga  ataatcctt  gtggacctt  ttaatagct  2820
ctattcctg  tttgctttg  accattctc  tctttatgg  tcaacaaat  acagctgta  2880
ttataaaca  aaaggaaca  aaattgaag  aaggagctg  ctatcacct  gatttgctc  2940
tggttggcg  tatgttggg  gtttgctct  tcatgggac  tccatggtt  gtggctgca  3000
cagtgttgt  aataagtca  gtcaacagc  taaaagttg  atctgaatg  tctgctcca  3060
gggaacaac  caagttttt  ggaattcgt  aacagcggg  tacagggct  atgattttt  3120
ttctaatgg  cctctctgt  ttcatgact  cagtcctaa  gtttattcc  atgcctgtt  3180
tgtatggtg  tttccttta  atgggagtt  cctcattaa  aggaatcca  ttatttgac  3240
gtataaaat  atttggaat  cctgctaag  atcagcctg  tttgatata  ctccgttat  3300
tgccgctct  gaaggtcca  attttcaca  tcattcagc  tacttgttt  gtcctttta  3360
gggtgataa  agtttcagc  gctgcagtg  tttttccca  gatggttct  gcattagtg  3420
ttgtgcgca  actcatgga  ctgtgtttc  cgaagagag  acttagttg  cttgatgat  3480
ttatgccag  aagtaagaa  aagaaagaa  atgacaaaa  gaaaaaaga  aaagaggaa  3540
ctgaacgga  gcttcaaga  gatgatgat  ctgtgcacc  tccatttga  gggggaagt  3600
tcttgcaaa  tccagtcaa  gccctaaaa  atagtcctg  taaacctgt  agtgtgaaa  3660
taagttttg  agatgaacc  agaaagaaa  acgtggatg  tgaaacttc  ttatagaat  3720
gaaccaaga  gcattatac  tatagatat  tacatatgt  atgtgtgcg  atcatgtca  3780
tatatataa  aatattgta  gtcatgctg  ttatgtgtg  ctaccgggt  tttaaaagt  3840
gtgtctgga  tttgtaatg  gcaccgtgg  gactatgta  ttaatgaaa  gctctcttt  3900
aagtgaggt  catggttct  aactattca  atatttatt  tgttagaaa  aaaaaattt  3960
ctgttttgc  atagaagga  gtggagaaa  gctttcagt  tacttttct  aaatctctg  4020
tcatcagtg  caattcgta  aaaccttaa  tgatacttt  tttatatgt  tataatttt  4080
aggtgtttc  tgaaatttt  acatattat  tcacttttg  tagtgcttt  tgggaagaa  4140
agggagtct  taccagtgc  gtgggaaaa  tggtaacat  tcagggctt  tctatttgt  4200
tttcatttc  gtagatgtc  atcgtgttt  actaactgg  gttttctta  ccatagaga  4260
gactgtaga  caatagaaa  tttaataat  atagttttt  acttttatg  ttaaatttt  4320
tttaaatct  aaaaccttc  tatctaggt  tccattgtg  cagacaagt  aaattgcag  4380
tgatttgat  attaagcac  cataccatt  ataacttct  aatttaaaa  gttatacaa  4440
gccagtttg  aatagttga  tttgatgcc  ttgtagaat  ttttttctg  atccttatg  4500
tcttttaaa  ccaatgatt  ccactctgt  ctctgcctt  tctctcttt  tcttaaaat  4560
ctttagttt  catcaggtt  aagttcttg  ctattattc  cttataagt  gtaggcgta  4620
ataatcagg  gttagaatt  tctcagaag  gtctatgat  agtattact  tattaagaa  4680
tacctttca  tttctcttt  tgttattct  tcacttttg  agattacat  taatagctt  4740
ttacctgtg  ttttatttt  aaatattta  tttgatatg  tgcttaaat  ttatataaa  4800
atttggaaa  gtaacaaat  gagtaaatt  ttaatgtaa  tagttggtg  ttactttca  4860
ttatgttta  tatcttaaa  caattgata  attttacat  tttgatata  agcactgcc  4920
tatttatat  ttaaaagga  attagacat  ttatatgta  ctcagatta  tgacatttt  4980
attttgtgt  ttagttttt  cttttctga  ctttttaaa  tctaacaaa  ctttttagt  5040
atcttttat  tacttttag  tccacatga  ataaatgtt  ttaagcctg  aggactgga  5100
gaatggggt  gtgaaactg  tttgacaag  gaataattt  caaaaatca  atgagtatt  5160
agaagccac  gaaatatca  aaatggtga  atcactatt  ggatgaaaa  tttatgaaa  5220
tccaatgct  cctttaacc  tataattaa  ttacaaagg  atacataat  aatctaata  5280
aggatcatg  ggaatgcca  aagctgaaa  tttagcaag  ctggtgttt  aaattcatt  5340
taaactatt  attaactaa  gtaatgtcc  cctctaaga  catattgta  gagtcttgt  5400
aaaatgatg  attcaactt  tgcctcgga  gagaggttg  aaatgtagc  gcttttctt  5460
agaaaatat  tagctgtca  catttggta  tgcctaaaa  gagttagac  ctattggca  5520
ttgatagag  attacccac  gtgcttatt  ttgtttatg  gcttccatt  taatgattc  5580
tttttattt  tagcagcat  attatttcc  aagacccca  tatttgctg  tatttttaa  5640
actcccctg  tgtacctga  caagaggat  tcctcacat  atttccttg  gtctggaca  5700
caggggtaa  aactgtact  actttacag  aagaaattt  aaaactgaa  actacctgg  5760
atcatagtg  ttctgtgat  ttatttaat  gtgtatagt  attatccag  gccagaaaa  5820
ccgtcactt  caaaatact  tgcactcaa  atgttttta  aatgcttct  aatgttact  5880
gtttctgct  tcttttgac  acttgactg  caaaatgat  tgactactc  atttaagag  5940
aaaggtaac  catgtttaa  taattaact  cttgtttta  gtgattata  ttcttccac  6000
gtttttgaa  aataatcaa  gatagcatt  attgagaga  agtgacaga  ataatttac  6060
acatatatt  atttttaaa  aaagttgcc  taaataagt  tatgtaagc  gtagtagtt  6120
ctatgtact  atttacctc  aggtgcaaa  taattaaac  tgtacatat  ccatttaca  6180
aataaattc  gccctgcac  ttctttaga  gccttgatt  ccagaatgg  gcttagtgc  6240
actgaatac  ctggccaca  agccacctc  ggatattct  ttctccacc  tagtttatt  6300
atttataga  atctgttta  aaagtctgt  gtaaatcct  atgctgacc  tctgaaatg  6360
acttttttt  tgaatgctg  ttcaatcta  aatagcagc  tttgagaaa  caatgatgt  6420
aattcctta  gataaaagg  tgattctat  tattcttta  tgatattaa  tatgccgaa  6480
ccaagcaca  agtctttct  aagtgtgtg  atgtttgtg  gaatgtgaa  gatactgat  6540
ttatatctg  taaaagttg  tttaaaaag  tgtggcatc  cattgttca  atttgccaa  6600
tcttctgta  agatgtcta  gacgaaata  tttatgtgc  aatgcatgt  tttgtaaac  6660
agatttgtt  accactcaa  attaacttg  tttcttcat  caaaaaagt  tatgtcttc  6720
acgtactta  attttctgt  tgggtataa  atagctttc  aattttttt  tttcacaaa  6780
gcaggttca  aattctgtt  aaagaaaaa  gctttctga  actgaggta  aacaccaga  6840
cttgctgtt  aaaggatta  atgatgtac  tcagttcta  aaatgtgct  agcagttta  6900
catgtgaat  ctgttttaa  gtgctcaga  ttcaactgt  taagccatt  atataacgc  6960
gtaattaaa  atgtttata  gaaataact  aatgtttta  atttattta  gtagatcac  7020
tcattttta  cagtatgca  tgcaaatat  tgaaatgtc  tttggttta  tccaacaat  7080
atttatttt  gaaagtaag  ttaaagact  taaggacat  caaagttta  aatagtgtt  7140
aaattgcaa  atttggcaa  cttcatata  attggtttc  tttctaact  ttcaaaaac  7200
aacattaaa  gtcaattat  ggaaaacat  gttggaaat  taatcatcc  aaagatcat  7260
tttaaaatg  aatttaatt  gcacatatt  aacatttga  ttaattgtt  aaccccagt  7320
ttgttttgt  tttttaatc  gatttttgc  cactgatta  tttttgtgt  gtggctttt  7380
ttgctttat  attcaaggt  ttttttttt  tttccccat  ggggagatt  tcttccaat  7440
tttaactac  tttaaataa  taaaaattg  attttattg  tcatttata  aaaatctga  7500
accttgatg  aatttcaca  tacagttcc  atttttatg  cttttataa  tacaatgat  7560
ttttcttct  taataaaat  caaagtaaa  atttaaatt  tagaactga  atttttcat  7620
tatatgaag  ataagcctc  actgggtct  tattgtgaa  catcctgcc  ttcaaattt  7680
tttcataat  gttagatga  aactatttt  ttggagatg  tactgaagt  gattgagca  7740
taaaagtct  cttaattaa  aaaaaaaaa  aaaaaaaaa  aaaaa  7785



<210> 5781
<211> 1214
<212> PRT
<213> Homo sapiens
<308> AAD38322
<400> 5781

Met Glu Arg Phe Arg Leu Glu Lys Lys Leu Pro Gly Pro Asp Glu Glu 
  1               5                  10                  15
Ala Val Val Asp Leu Gly Lys Thr Ser Ser Thr Val Asn Thr Lys Phe 
             20                  25                  30
Glu Lys Glu Glu Leu Glu Ser His Arg Ala Val Tyr Ile Gly Val His 
         35                  40                  45
Val Pro Phe Ser Lys Glu Ser Arg Arg Arg His Arg His Arg Gly His 
     50                  55                  60
Lys His His His Arg Arg Arg Lys Asp Lys Glu Ser Asp Lys Glu Asp 
 65                  70                  75                  80
Gly Arg Glu Ser Pro Ser Tyr Asp Thr Pro Ser Gln Arg Val Gln Phe 
                 85                  90                  95
Ile Leu Gly Thr Glu Asp Asp Asp Glu Glu His Ile Pro His Asp Leu 
             100                105                110
Phe Thr Glu Met Asp Glu Leu Cys Tyr Arg Asp Gly Glu Glu Tyr Glu 
         115                120                125
Trp Lys Glu Thr Ala Arg Trp Leu Lys Phe Glu Glu Asp Val Glu Asp 
     130                135                140
Gly Gly Asp Arg Trp Ser Lys Pro Tyr Val Ala Thr Leu Ser Leu His 
 145                150                155                160
Ser Leu Phe Glu Leu Arg Ser Cys Ile Leu Asn Gly Thr Val Met Leu 
                 165                170                175
Asp Met Arg Ala Ser Thr Leu Asp Glu Ile Ala Asp Met Val Leu Asp 
             180                185                190
Asn Met Ile Ala Ser Gly Gln Leu Asp Glu Ser Ile Arg Glu Asn Val 
         195                200                205
Arg Glu Ala Leu Leu Lys Arg His His His Gln Asn Glu Lys Arg Phe 
     210                215                220
Thr Ser Arg Ile Pro Leu Val Arg Ser Phe Ala Asp Ile Gly Lys Lys 
 225                230                235                240
His Ser Asp Pro His Leu Leu Glu Arg Asn Gly Glu Gly Leu Ser Ala 
                 245                250                255
Ser Arg His Ser Leu Arg Thr Gly Leu Ser Ala Ser Asn Leu Ser Leu 
             260                265                270
Arg Gly Glu Ser Pro Leu Ser Leu Leu Leu Gly His Leu Leu Pro Ser 
         275                280                285
Ser Arg Ala Gly Thr Pro Ala Gly Ser Arg Cys Thr Thr Pro Val Pro 
     290                295                300
Thr Pro Gln Asn Ser Pro Pro Ser Ser Pro Ser Ile Ser Arg Leu Thr 
 305                310                315                320
Ser Arg Ser Ser Gln Lys Ser Gln Arg Gln Ala Pro Glu Leu Leu Val 
                 325                330                335
Ser Pro Ala Ser Asp Asp Ile Pro Thr Val Val Ile His Pro Pro Glu 
             340                345                350
Glu Asp Leu Glu Ala Ala Leu Lys Gly Glu Glu Gln Lys Asn Glu Glu 
         355                360                365
Asn Val Asp Leu Thr Pro Gly Ile Leu Ala Ser Pro Gln Ser Ala Pro 
     370                375                380
Gly Asn Leu Asp Asn Ser Lys Ser Gly Glu Ile Lys Gly Asn Gly Ser 
 385                390                395                400
Gly Gly Ser Arg Glu Asn Ser Thr Val Asp Phe Ser Lys Val Asp Met 
                 405                410                415
Asn Phe Met Arg Lys Ile Pro Thr Gly Ala Glu Ala Ser Asn Val Leu 
             420                425                430
Val Gly Glu Val Asp Phe Leu Glu Arg Pro Ile Ile Ala Phe Val Arg 
         435                440                445
Leu Ala Pro Ala Val Leu Leu Thr Gly Leu Thr Glu Val Pro Val Pro 
     450                455                460
Thr Arg Phe Leu Phe Leu Leu Leu Gly Pro Ala Gly Lys Ala Pro Gln 
 465                470                475                480
Tyr His Glu Ile Gly Arg Ser Ile Ala Thr Leu Met Thr Asp Glu Ile 
                 485                490                495
Phe His Asp Val Ala Tyr Lys Ala Lys Asp Arg Asn Asp Leu Leu Ser 
             500                505                510
Gly Ile Asp Glu Phe Leu Asp Gln Val Thr Val Leu Pro Pro Gly Glu 
         515                520                525
Trp Asp Pro Ser Ile Arg Ile Glu Pro Pro Lys Ser Val Pro Ser Gln 
     530                535                540
Glu Lys Arg Lys Ile Pro Val Phe His Asn Gly Ser Thr Pro Thr Leu 
 545                550                555                560
Gly Glu Thr Pro Lys Glu Ala Ala His His Ala Gly Pro Glu Leu Gln 
                 565                570                575
Arg Thr Gly Arg Leu Phe Gly Gly Leu Ile Leu Asp Ile Lys Arg Lys 
             580                585                590
Ala Pro Phe Phe Leu Ser Asp Phe Lys Asp Ala Leu Ser Leu Gln Cys 
         595                600                605
Leu Ala Ser Ile Leu Phe Leu Tyr Cys Ala Cys Met Ser Pro Val Ile 
     610                615                620
Thr Phe Gly Gly Leu Leu Gly Glu Ala Thr Glu Gly Arg Ile Ser Ala 
 625                630                635                640
Ile Glu Ser Leu Phe Gly Ala Ser Leu Thr Gly Ile Ala Tyr Ser Leu 
                 645                650                655
Phe Ala Gly Gln Pro Leu Thr Ile Leu Gly Ser Thr Gly Pro Val Leu 
             660                665                670
Val Phe Glu Lys Ile Leu Tyr Lys Phe Cys Arg Asp Tyr Gln Leu Ser 
         675                680                685
Tyr Leu Ser Leu Arg Thr Ser Ile Gly Leu Trp Thr Ser Phe Leu Cys 
     690                695                700
Ile Val Leu Val Ala Thr Asp Ala Ser Ser Leu Val Cys Tyr Ile Thr 
 705                710                715                720
Arg Phe Thr Glu Glu Ala Phe Ala Ala Leu Ile Cys Ile Ile Phe Ile 
                 725                730                735
Tyr Glu Ala Leu Glu Lys Leu Phe Asp Leu Gly Glu Thr Tyr Ala Phe 
             740                745                750
Asn Met His Asn Asn Leu Asp Lys Leu Thr Ser Tyr Ser Cys Val Cys 
         755                760                765
Thr Glu Pro Pro Asn Pro Ser Asn Glu Thr Leu Ala Gln Trp Lys Lys 
     770                775                780
Asp Asn Ile Thr Ala His Asn Ile Ser Trp Arg Asn Leu Thr Val Ser 
 785                790                795                800
Glu Cys Lys Lys Leu Arg Gly Val Phe Leu Gly Ser Ala Cys Gly His 
                 805                810                815
His Gly Pro Tyr Ile Pro Asp Val Leu Phe Trp Cys Val Ile Leu Phe 
             820                825                830
Phe Thr Thr Phe Phe Leu Ser Ser Phe Leu Lys Gln Phe Lys Thr Lys 
         835                840                845
Arg Tyr Phe Pro Thr Lys Val Arg Ser Thr Ile Ser Asp Phe Ala Val 
     850                855                860
Phe Leu Thr Ile Val Ile Met Val Thr Ile Asp Tyr Leu Val Gly Val 
 865                870                875                880
Pro Ser Pro Lys Leu His Val Pro Glu Lys Phe Glu Pro Thr His Pro 
                 885                890                895
Glu Arg Gly Trp Ile Ile Ser Pro Leu Gly Asp Asn Pro Trp Trp Thr 
             900                905                910
Leu Leu Ile Ala Ala Ile Pro Ala Leu Leu Cys Thr Ile Leu Ile Phe 
         915                920                925
Met Asp Gln Gln Ile Thr Ala Val Ile Ile Asn Arg Lys Glu His Lys 
     930                935                940
Leu Lys Lys Gly Ala Gly Tyr His Leu Asp Leu Leu Met Val Gly Val 
 945                950                955                960
Met Leu Gly Val Cys Ser Val Met Gly Leu Pro Trp Phe Val Ala Ala 
                 965                970                975
Thr Val Leu Ser Ile Ser His Val Asn Ser Leu Lys Val Glu Ser Glu 
             980                985                990
Cys Ser Ala Pro Gly Glu Gln Pro Lys Phe Leu Gly Ile Arg Glu Gln 
         995                1000                1005
Arg Val Thr Gly Leu Met Ile Phe Ile Leu Met Gly Leu Ser Val Phe 
     1010                1015                1020
Met Thr Ser Val Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val 
 1025                1030                1035                1040
Phe Leu Tyr Met Gly Val Ser Ser Leu Lys Gly Ile Gln Leu Phe Asp 
                 1045                1050                1055
Arg Ile Lys Leu Phe Gly Met Pro Ala Lys His Gln Pro Asp Leu Ile 
             1060                1065                1070
Tyr Leu Arg Tyr Val Pro Leu Trp Lys Val His Ile Phe Thr Val Ile 
         1075                1080                1085
Gln Leu Thr Cys Leu Val Leu Leu Trp Val Ile Lys Val Ser Ala Ala 
     1090                1095                1100
Ala Val Val Phe Pro Met Met Val Leu Ala Leu Val Phe Val Arg Lys 
 1105                1110                1115                1120
Leu Met Asp Leu Cys Phe Thr Lys Arg Glu Leu Ser Trp Leu Asp Asp 
                 1125                1130                1135
Leu Met Pro Glu Ser Lys Lys Lys Lys Glu Asp Asp Lys Lys Lys Lys 
             1140                1145                1150
Glu Lys Glu Glu Ala Glu Arg Met Leu Gln Asp Asp Asp Asp Thr Val 
         1155                1160                1165
His Leu Pro Phe Glu Gly Gly Ser Leu Leu Gln Ile Pro Val Lys Ala 
     1170                1175                1180
Leu Lys Tyr Ser Pro Asp Lys Pro Val Ser Val Lys Ile Ser Phe Glu 
 1185                1190                1195                1200
Asp Glu Pro Arg Lys Lys Tyr Val Asp Ala Glu Thr Ser Leu 
                 1205                1210



<210> 5782
<211> 482
<212> DNA
<213> Rattus norvegicus
<308> AA892417
<400> 5782

ccattaaaa  accaaaaac  tcactttat  atgaatcca  gaacactgt  taaaaaacc  60
ccagtcgta  aaatgaaca  acagcacgt  tatatacag  cactgtaca  gtgggccct  120
ccctttaag  taaactcca  agactatac  catgggcac  gcccttaca  ctatactcc  180
aaaccaggc  gctatagtc  tcctgctgg  acagcttca  ggaatgctg  cccagggaa  240
gggaggatg  agtcagtgc  gggctacaa  actctctgg  agcccagca  gtggaaatc  300
tgcagagat  ctgggtcag  ccaagctgt  tctcttgta  ctggcttcc  cgcaggaag  360
tgtctcaag  ttttccttt  gtcagttca  ctgcaaatt  tggcttcct  ggggaagga  420
atttttnac  agttcagtg  ccaactgca  ggnctcagg  tctttcagc  catctccca  480
tg  482



<210> 5783
<211> 205
<212> PRT
<213> Rattus norvegicus
<308> P97553
<400> 5783

Met Glu Phe Leu Trp Ala Pro Leu Leu Gly Leu Cys Cys Ser Leu Ala 
  1               5                  10                  15
Ala Val Asp Arg His Ile Val Phe Trp Asn Ser Ser Asn Pro Lys Phe 
             20                  25                  30
Arg Glu Glu Asp Tyr Thr Val His Val Gln Leu Asn Asp Tyr Leu Asp 
         35                  40                  45
Ile Ile Cys Pro His Tyr Glu Asp Asp Ser Val Ala Asp Ala Ala Met 
     50                  55                  60
Glu Arg Tyr Ser Leu Tyr Met Val Glu His Gln Glu Tyr Val Thr Cys 
 65                  70                  75                  80
Glu Pro Gln Ser Lys Asp Gln Val Arg Val Lys Cys Asn Gln Pro Ser 
                 85                  90                  95
Ala Lys His Gly Pro Glu Lys Leu Ser Glu Lys Phe Gln Arg Phe Thr 
             100                105                110
Pro Phe Thr Leu Gly Lys Glu Phe Lys Glu Gly His Ser Tyr Tyr Tyr 
         115                120                125
Ile Ser Lys Pro Ile Tyr His Gln Glu Thr Gln Cys Leu Lys Leu Lys 
     130                135                140
Val Thr Val Asn Gly Lys Ile Thr His Ser Pro His Ala His Val Asn 
 145                150                155                160
Pro Gln Glu Lys Arg Leu Gln Ala Asp Asp Pro Glu Val Gln Val Leu 
                 165                170                175
His Ser Ile Gly His Ser Ala Ala Pro Arg Leu Phe Pro Leu Val Trp 
             180                185                190
Ala Val Leu Leu Leu Pro Leu Leu Leu Leu Gln Thr Gln 
         195                200                205



<210> 5784
<211> 1480
<212> DNA
<213> Homo sapiens
<308> M57730
<400> 5784

gcggagaaa  ccagtggga  cccagaccc  taggagacc  gcgtccccg  tcggcctgg  60
caggccccg  gctatggag  tcctctggg  ccctctctt  ggtctgtgc  gcagtctgg  120
cgctgctga  cgccacacc  tcttctgga  cagttcaaa  cccaagttc  ggaatgagg  180
ctacaccat  catgtgcag  tgaatgact  cgtggacat  atctgtccg  actatgaag  240
tcactctgt  gcagacgct  ccatggagc  gtacatact  tacctggtg  agcatgagg  300
gtaccagct  tgccagccc  agtccaagg  ccaagtccg  tggcagtgc  accggccca  360
tgccaagca  ggcccggag  agctgtctg  gaagttcca  cgcttcaca  ctttcaccc  420
gggcaagga  ttcaaagaa  gacacagct  ctactacat  tccaaaccc  tccaccagc  480
tgaagaccg  tgcttgagg  tgaaggtga  tgtcagtgg  aaaatcact  acagtcctc  540
ggcccatgt  aatccacag  agaagagac  tgcagcaga  gacccagag  tgcgggttc  600
acatagcat  ggtcacagt  ctgccccac  cctcttccc  cttgcctgg  ctgtgctgc  660
ccttccact  ctgctgctg  aaaccccgt  aaggtgtat  ccacacctg  ccttaaaga  720
ggacaggct  aagagaggg  caggcactc  aaacctgtc  tggggccac  ttcagagcc  780
ccagccctg  gaaccactc  caccacagg  ataagctat  acctagcag  ctcaaaacg  840
gtcagtatt  aggttttca  ccggaagga  gccaaccag  ccgacagtg  catccccac  900
ttcacctcg  agggacgga  aaagaagtg  agacagtcc  ttcccacca  tcctgcctt  960
aagccaaag  aacaagctg  gcaggcatg  tcccttaag  cacagtggg  gctgagctg  1020
aaggggcca  gtggatggg  aaagcttgt  aaagatgcc  cctccagga  agagccagg  1080
tgcccagat  aactgactg  aggaaaagc  agaaacagt  tcttgcttg  aagccaggt  1140
caggagagg  agcatgctt  ggctgaccc  gcatctccc  gcaagacct  atctgtgga  1200
ctgccacag  gaagtttgt  gccaggtac  gcattctct  ccatcctgg  gcagcactc  1260
ccagagctg  gccagcagg  gggctgtgc  aacctgttc  tagagtgta  ctgtaaggg  1320
agtgcccat  tgtacattc  gcctagagt  tagcctaaa  ggcagggcc  acgtgtata  1380
tatctgtat  taagttgct  tgtgtctgt  ctgatttct  caactggag  ttttttata  1440
aatgttctt  gtctcaaaa  aaagcaatg  gttttttcgg  1480



<210> 5785
<211> 205
<212> PRT
<213> Homo sapiens
<308> P20827
<400> 5785

Met Glu Phe Leu Trp Ala Pro Leu Leu Gly Leu Cys Cys Ser Leu Ala 
  1               5                  10                  15
Ala Ala Asp Arg His Thr Val Phe Trp Asn Ser Ser Asn Pro Lys Phe 
             20                  25                  30
Arg Asn Glu Asp Tyr Thr Ile His Val Gln Leu Asn Asp Tyr Val Asp 
         35                  40                  45
Ile Ile Cys Pro His Tyr Glu Asp His Ser Val Ala Asp Ala Ala Met 
     50                  55                  60
Glu Gln Tyr Ile Leu Tyr Leu Val Glu His Glu Glu Tyr Gln Leu Cys 
 65                  70                  75                  80
Gln Pro Gln Ser Lys Asp Gln Val Arg Trp Gln Cys Asn Arg Pro Ser 
                 85                  90                  95
Ala Lys His Gly Pro Glu Lys Leu Ser Glu Lys Phe Gln Arg Phe Thr 
             100                105                110
Pro Phe Thr Leu Gly Lys Glu Phe Lys Glu Gly His Ser Tyr Tyr Tyr 
         115                120                125
Ile Ser Lys Pro Ile His Gln His Glu Asp Arg Cys Leu Arg Leu Lys 
     130                135                140
Val Thr Val Ser Gly Lys Ile Thr His Ser Pro Gln Ala His Val Asn 
 145                150                155                160
Pro Gln Glu Lys Arg Leu Ala Ala Asp Asp Pro Glu Val Arg Val Leu 
                 165                170                175
His Ser Ile Gly His Ser Ala Ala Pro Arg Leu Phe Pro Leu Ala Trp 
             180                185                190
Thr Val Leu Leu Leu Pro Leu Leu Leu Leu Gln Thr Pro 
         195                200                205



<210> 5786
<211> 498
<212> DNA
<213> Rattus norvegicus
<308> AA892425
<400> 5786

gaactctaa  aatgtgata  gtgccacac  aaacattag  cacagtatc  gcccggtgg  60
cgtacaatc  aatctaagg  cacagatca  tttttgaat  ttgccatga  ctttctgtt  120
atgagaatg  ggtattaag  gcaccgttc  gtgcaggaa  ggacccaca  aatcactga  180
ctttcagga  ggtttgcct  cataagtac  accaactgc  catgtttct  attcttggg  240
attatggat  gtgtttttc  ttcatttta  gatgagcac  acaatctat  aggacagaa  300
cactaaacc  acaaatctg  caaaaccag  gttcaaaac  ggcctctag  ccaaaataa  360
attgttgta  gttcagaaa  tcagctaaa  taggaccta  agaaagtgt  aggagccat  420
tttgttcag  gtcncccta  tgtccanac  gtctctctc  tcaaagcag  tttcaaagt  480
ccctttatc  caagtctt  498



<210> 5787
<211> 333
<212> DNA
<213> Homo sapiens
<308> AA411025
<400> 5787

tgttgttga  cgtttattg  gctctaaca  tgtgacagg  gccacacaa  acattagac  60
cagtacctg  ccagtggcg  tacaatcta  tctaaggac  tgaatcttt  ttttttttt  120
aagacagag  ctcactctg  cacccaggc  ggagtgcag  ggcaaatct  ggctcactg  180
aacctccac  ccccgggtt  aagcaattc  cctgcctca  cctcccgag  agctgagat  240
acaggcgtc  gcaccacgc  cggctaatt  tttgtattt  ttagtagag  tggggtttc  300
ctatgttgg  caggctcgt  ttgaactcc  gac  333



<210> 5788
<211> 446
<212> DNA
<213> Rattus norvegicus
<308> AA892465
<400> 5788

acataaaag  tgtcaaaat  ctgactcac  tcaaaaatg  aaaataatg  aatatactt  60
taaacgtag  cgcaggtct  gcagcaagg  gactgagag  gcagtgaac  ttatggagg  120
ctgcacaca  acagagccg  cacctcaat  ctgcagact  aacaggaac  gcacattct  180
tgaggagag  gcgagccgg  tcacttgaa  taggagtag  agccattgc  tcccgggct  240
ctgcccaag  tgagctcct  gaacaggga  agtgggtcg  tgcccttct  ggcctgctc  300
ggcggaggc  tgggcttgg  cggggcccg  agcgcactg  cataggaca  ggcgggctt  360
ctccctgcc  ggctctgct  gctgctgct  ttggcagac  ccgcgatct  cttgttggg  420
atgaggggt  ggaactggc  gaggtg  446



<210> 5789
<211> 6274
<212> DNA
<213> Homo sapiens
<308> D29677
<400> 5789

gaaagtaat  acaggattt  gatgaagta  tggatcact  atgaactac  gtgctggtg  60
gatgtgtaa  aaattataa  gagctctga  gggctattt  ggtgatacc  agtgcagtg  120
actgcagga  ttttgtccc  gagtcatgg  agacagaag  gctgaaaag  catgtgaac  180
agcatgtga  tcacttaag  ggcaggact  tgaaatggc  ctcaagcac  gcacagagg  240
ccttctttc  cttggccag  actccatgg  agacttcac  gggccttgt  cattggaaa  300
agaacgcat  acaatcgag  gtcttctct  cagaattgc  tcatttttg  aactgaaaa  360
ttatgtgca  gctgatgaa  attgtagac  tgtgctggg  gaaggactg  ccaagggag  420
agatgcctt  cgggcagtg  tttgctgca  gcagctgaa  gggaagctc  aacctgtat  480
caccattct  gccaagtca  tcacaggag  gtccctgaa  gggatggta  caaaggatt  540
gacaagact  aaaacactt  tctcagaaa  agagacagc  actagtaac  ccctctctg  600
atatcacgt  gaagactta  atgaggggt  ttgtaatgg  tggcatttc  gcccaccac  660
taggggaat  acaagcagc  aggaatata  tttgtgtaa  agattttta  aacaaggaa  720
ctgtaggta  ggtgcccag  gtacttcag  acattccca  gaagaacta  cagaatggc  780
gaaaagata  gcttcacgg  tgataaaat  gaaacagca  aatgagaat  aacagctct  840
aggcagtta  atggaaacc  tgatagaaa  gtggatgaa  tcattgtct  ctgagaaag  900
gcttagtga  tgtatagaa  gagtaaagg  agagcacaa  cctgacctg  cagttactg  960
cagcaccaa  aaatcccac  agacatgga  ctttgctct  acttgtaag  ctgcaagaa  1020
gctgtatcg  gtagcattg  tttatgatg  tcatcgtcc  cattttagt  tcattgcaa  1080
atctgccgg  gatagtact  cccaggtat  acaagaagt  ccagaaaac  gtcaagaat  1140
gataggagg  aagatggcc  aaaatggat  agatcatta  gtgtataaa  tcgggatag  1200
atttaacac  gaaatattt  gaacttttc  ccaaaccat  gttttcgac  ttggattgg  1260
accagtact  atgcaaaga  taatgattg  tgcagcttc  acagaagat  tcgaatacc  1320
gatgcatgc  aaacagcag  tagtaacca  agctaaacg  tgggattct  cctctaaga  1380
tattataga  tttgaacct  atgaaacta  tgatttgga  aagagcctt  ttatcagat  1440
ccaaattcc  ctctctgct  accagctat  tactcagtc  gttttagac  aatcattga  1500
caagagcaa  tatcagtca  ggttacatg  ccttcttta  attgaggag  tagcccagt  1560
taaagaaat  agcaagttc  accttaaag  gcaattgca  attctggca  gcttcatgc  1620
cactggtgt  tctggaggt  caaagtatg  tcagaatgg  caacttttt  gtcgcttta  1680
gcttactga  acactttct  aagatactt  ggctggacg  ctggtgatg  ccaaagtca  1740
tgctgttta  ttattacca  tccctaaac  gaagttagt  cagacccag  gaaccaaag  1800
gaaggttta  gaagctact  ttgaagaaa  aacaaagga  tatatattt  taaggctat  1860
tagggaatg  tgtgaagaa  ttaatcttc  gcctgactg  gacacacag  ttgaacttc  1920
gtttcaatt  aatcgatta  ccctctgtg  aatgcacta  gcactagac  ggatcaagg  1980
caatggggt  ttgtttcca  acatcagta  gactcccac  ataccatgg  gtcctaaca  2040
acaatggga  gaacagttg  atcctcgac  aaatgcaaa  cagaaagag  ctgttctgg  2100
cattaccac  ccacttgca  tccagctgc  gcctgtgct  atcatcgga  cctatggga  2160
aggcaaaac  ttcactcta  ctcaggctg  caaacatat  ctgcagcaa  aggagacta  2220
gattctcat  tgcacccat  ctaatagtg  tgctgatct  tacataaag  attatttac  2280
tccatatgt  gaagcaggc  atccccagg  aagacctct  agggtatat  tcagaaatc  2340
ctgggtaaa  actgtccac  cagttgtgc  tcagtactg  ttgatctca  gcgcacatt  2400
cacctttca  atgccccag  aagaagata  tcttaaaca  cgagtggtg  ttgttacct  2460
gaatacttc  cagtacctc  gtcagttgg  ccttgaacc  gggtttttt  cacacattc  2520
attagatga  gctgcccag  ccatggagt  tgaaaccat  atgcctcta  cattagcaa  2580
tcaaaacac  cggattgtc  tggctggtg  tcacatgca  ctcagtcct  ttgtttaca  2640
cgagtttgc  agggagaga  accttcacg  ttcattact  gaccgactc  atgagcatt  2700
ccctgctga  ttcccatgt  ggattctcc  gtgtgagaa  taccgctcc  atgaagcta  2760
catcaatta  acctctgag  ttttctatg  gggcaaact  atggccagt  ggaagcagc  2820
agcacacaa  gatttctac  cactaactt  ctttacagc  cgaggagaa  atgtacaag  2880
aaaaaatag  acagctttt  ataataatg  agaggtgtt  gaagtggtg  aacgtgtag  2940
agagttaag  aggaagtgg  cagtagcgt  ggggaagtt  gatgatggc  gtattggtg  3000
ggtgactcc  tatgctgat  aagtgttta  aatacgtgc  gaacttcga  aaaagagat  3060
atctgatgt  aatgtagaa  gggtgctaa  tgttcaagg  aagcaattc  gagttttgt  3120
tcttagcac  gtacgtaca  gacatactt  taaacataa  cagacacca  ttaaaaaga  3180
agagcaact  ctggaagat  ccacagagg  cttagatta  ggtttttta  ctaactaca  3240
gcttctcaa  actgccatc  caagagcac  atccctggt  gctgtggtg  gtgatccca  3300
tgctctgtg  tctattgga  gatgcagga  attttggga  cggtttatt  ccctgtgtc  3360
tgaaaacag  agcctacat  gaatcactt  tgaacagat  aaagcccag  tagaggctt  3420
agaactaaa  aagacatat  tgttgaatc  gctggcacc  gaatttatc  cccgggctc  3480
aagactgca  cattcagga  gtaccaaca  acagcagca  tcaccaccc  aggggaaaa  3540
tcttcatca  acccagaat  atcacttcc  gaatgatgg  attgttcag  ccaatcctt  3600
tgtacttat  ggcaatcct  ttagagcat  tactcctcc  ccccctctt  gacctcacc  3660
aaatttggg  aaatctcca  gccctgttc  aagaataga  cctcacact  ggacaagta  3720
tctttatgt  cctgctgtc  atggaggga  tgtagttat  tcggtgcct  tacctgtac  3780
atggacagg  taccagggt  ggtttgcag  tgatcctcg  attattaca  atcaggcag  3840
aatggccta  aacatgaac  tattacaga  acatggacg  ggatctcct  ttccttatg  3900
ccttggaca  cacccacct  tcaccatag  ccagccaca  aatcagcat  aggagaagg  3960
tcaacatga  caaaatcga  atggtaaaa  tgatacaaa  aattccgga  ctgaaatta  4020
taagattcg  acaccagag  aaaagccaa  agaaccaaa  caggttgat  tggaatcaa  4080
tccacagaa  agaagtcct  aatcacgtc  tagtgttgt  tatcccagt  ccaaatttc  4140
tcgcaaaga  aatctcaac  caagacaca  aaatcttcc  cttcctgct  cccacgcac  4200
gtatgcaat  cctaatcgc  actttcatc  ccttcccca  ctaccaaga  caccctttc  4260
aattccaca  cagcacacc  tgttaaatc  gcagcagaa  aatttgcct  aacaaccaa  4320
tcagatacc  cctcagcca  atcaggtag  ccagcagca  agtcagttg  atcagcagc  4380
tcagcagcc  cctcctcag  tttctcctg  atatcaggc  ggacccaac  atgcttttt  4440
taatagtgc  gttgctcat  ggccacagt  tcctcctgc  gaagctgta  ttccggagc  4500
gcagccccc  cccatgctg  aagaaggcc  cagtcctct  agagccatt  cacaacccg  4560
ccccattct  ccttcacat  tgaatagct  cattgatga  aacccctcg  gattaccta  4620
aggggaggc  ttagatcgt  tacatggga  tgtcgctct  gaaacatta  ggcagcagc  4680
ggcacggtt  cagcagtgg  gcgagcatc  tgcctttct  agtcagggc  gcgttccat  4740
cccacacca  caccatcct  acctccagc  tcttcctca  ccgcccctg  gattacatc  4800
gccgccagt  agggcagac  ggaagctca  cagcagtgc  gaagatgaa  tggagacca  4860
atactcaag  tttcaagac  taatcagag  actgtctca  cgtgatcaa  gtgaaacac  4920
ggaactagc  gaaatgcca  cacctcaat  aagactttt  caatataga  aagtacaga  4980
tagaagccc  ccagcagtc  catctcccc  atccagtac  gaccacagt  gccactttt  5040
taactttaa  gataacagc  gagacattg  agtagccag  aacccagca  ttccacagc  5100
cctcccacc  cagatattc  actcacctt  ctcgttgcc  tctgaacac  ttgcccctc  5160
tcccttgaa  tacctggca  ctgatggag  atggacttt  gctaacttg  aacagaatc  5220
cctaatggg  ccaggtttt  cctatggcc  acctccatt  cctcacagg  caccgcaga  5280
cccttttgt  caaatacag  atcatcaac  tgctattgg  caagagcca  ttcacccat  5340
gtcatctcg  acagtatct  cttcttcgc  ccctagctt  gaagagtat  agcccagag  5400
acctggtcg  cccttgtac  aaagaagaa  ctcatctag  tcagttcaa  cttgttctg  5460
agaagtaag  actcctcaa  acagtctgg  tcagtgtaa  gagcttcag  accacagta  5520
ccaatcttc  ttcaacttt  catccccgg  gtcctgggt  aacaccacc  catctactc  5580
ttatcagaa  attccgtgc  atggatcca  caggacagc  cagcccaga  agttgatag  5640
gccacccaa  actgtcaaa  cccctgagg  tcaactgaa  tcggagaac  tcgaggtgt  5700
cagttcctt  aactacagt  tgctgcagc  tcttggcca  tttccaccc  ttatgccta  5760
caagcagat  gcggagtcg  ccaatagca  tagccccca  agctctgcg  ggggcaagc  5820
cgccatgtc  tatgccagc  ctctgcggg  ccctccaaa  cccaggccc  ctcctgagc  5880
ggccaagaa  agtagcgac  ctctgtctc  cttccagga  ctgagccta  ggagctcat  5940
tggcagcaa  ggcttttac  catatttta  ataatcact  ttttttccc  caagggaga  6000
tgttttaat  tctgtttgt  tcagtagaa  taaggtagt  ggacttcat  tatagatgc  6060
cagttccct  tgttttaat  ttaaatatg  tctcactta  ttgctttgc  gctagactt  6120
caactaatt  ttttaaagt  tattccatt  ttttgcatt  ttgatgtgt  aaaactttg  6180
cagctttta  gtagaataa  aaaattttt  aatttgtgt  ttgttacat  tgtttgcat  6240
aagctagca  ccaagaggt  aattgtgca  ctat  6274



<210> 5790
<211> 1942
<212> PRT
<213> Homo sapiens
<308> P42694
<400> 5790

Met Glu Asp Arg Arg Ala Glu Lys Ser Cys Glu Gln Ala Cys Glu Ser 
  1               5                  10                  15
Leu Lys Arg Gln Asp Tyr Glu Met Ala Leu Lys His Cys Thr Glu Ala 
             20                  25                  30
Leu Leu Ser Leu Gly Gln Tyr Ser Met Ala Asp Phe Thr Gly Pro Cys 
         35                  40                  45
Pro Leu Glu Ile Glu Arg Ile Thr Ile Glu Ser Leu Leu Tyr Arg Ile 
     50                  55                  60
Ala Ser Phe Leu Gln Leu Lys Asn Tyr Val Gln Ala Asp Glu Asp Cys 
 65                  70                  75                  80
Arg His Val Leu Gly Glu Gly Leu Ala Lys Gly Glu Asp Ala Phe Arg 
                 85                  90                  95
Ala Val Leu Cys Cys Met Gln Leu Lys Gly Lys Leu Gln Pro Val Ser 
             100                105                110
Thr Ile Leu Ala Lys Ser Leu Thr Gly Glu Ser Leu Asn Gly Met Val 
         115                120                125
Thr Lys Asp Leu Thr Arg Leu Lys Thr Leu Leu Ser Glu Thr Glu Thr 
     130                135                140
Ala Thr Ser Asn Ala Leu Ser Gly Tyr His Val Glu Asp Leu Asp Glu 
 145                150                155                160
Gly Ser Cys Asn Gly Trp His Phe Arg Pro Pro Pro Arg Gly Ile Thr 
                 165                170                175
Ser Ser Glu Glu Tyr Thr Leu Cys Lys Arg Phe Leu Glu Gln Gly Ile 
             180                185                190
Cys Arg Tyr Gly Ala Gln Cys Thr Ser Ala His Ser Gln Glu Glu Leu 
         195                200                205
Ala Glu Trp Gln Lys Arg Tyr Ala Ser Arg Leu Ile Lys Leu Lys Gln 
     210                215                220
Gln Asn Glu Asn Lys Gln Leu Ser Gly Ser Tyr Met Glu Thr Leu Ile 
 225                230                235                240
Glu Lys Trp Met Asn Ser Leu Ser Pro Glu Lys Val Leu Ser Glu Cys 
                 245                250                255
Ile Glu Gly Val Lys Val Glu His Asn Pro Asp Leu Ser Val Thr Val 
             260                265                270
Ser Thr Lys Lys Ser His Gln Thr Trp Thr Phe Ala Leu Thr Cys Lys 
         275                280                285
Pro Ala Arg Met Leu Tyr Arg Val Ala Leu Leu Tyr Asp Ala His Arg 
     290                295                300
Pro His Phe Ser Ile Ile Ala Ile Ser Ala Gly Asp Ser Thr Thr Gln 
 305                310                315                320
Val Ser Gln Glu Val Pro Glu Asn Cys Gln Glu Trp Ile Gly Gly Lys 
                 325                330                335
Met Ala Gln Asn Gly Leu Asp His Tyr Val Tyr Lys Val Gly Ile Ala 
             340                345                350
Phe Asn Thr Glu Ile Phe Gly Thr Phe Arg Gln Thr Ile Val Phe Asp 
         355                360                365
Phe Gly Leu Glu Pro Val Leu Met Gln Arg Val Met Ile Asp Ala Ala 
     370                375                380
Ser Thr Glu Asp Leu Glu Tyr Leu Met His Ala Lys Gln Gln Leu Val 
 385                390                395                400
Thr Thr Ala Lys Arg Trp Asp Ser Ser Ser Lys Thr Ile Ile Asp Phe 
                 405                410                415
Glu Pro Asn Glu Thr Thr Asp Leu Glu Lys Ser Leu Leu Ile Arg Tyr 
             420                425                430
Gln Ile Pro Leu Ser Ala Asp Gln Leu Phe Thr Gln Ser Val Leu Asp 
         435                440                445
Lys Ser Leu Thr Lys Ser Asn Tyr Gln Ser Arg Leu His Asp Leu Leu 
     450                455                460
Tyr Ile Glu Glu Ile Ala Gln Tyr Lys Glu Ile Ser Lys Phe Asn Leu 
 465                470                475                480
Lys Val Gln Leu Gln Ile Leu Ala Ser Phe Met Leu Thr Gly Val Ser 
                 485                490                495
Gly Gly Ala Lys Tyr Ala Gln Asn Gly Gln Leu Phe Gly Arg Phe Lys 
             500                505                510
Leu Thr Glu Thr Leu Ser Glu Asp Thr Leu Ala Gly Arg Leu Val Met 
         515                520                525
Thr Lys Val Asn Ala Val Tyr Leu Leu Pro Val Pro Lys Gln Lys Leu 
     530                535                540
Val Gln Thr Gln Gly Thr Lys Glu Lys Val Tyr Glu Ala Thr Ile Glu 
 545                550                555                560
Glu Lys Thr Lys Glu Tyr Ile Phe Leu Arg Leu Ser Arg Glu Cys Cys 
                 565                570                575
Glu Glu Leu Asn Leu Arg Pro Asp Cys Asp Thr Gln Val Glu Leu Gln 
             580                585                590
Phe Gln Leu Asn Arg Leu Pro Leu Cys Glu Met His Tyr Ala Leu Asp 
         595                600                605
Arg Ile Lys Asp Asn Gly Val Leu Phe Pro Asp Ile Ser Met Thr Pro 
     610                615                620
Thr Ile Pro Trp Ser Pro Asn Arg Gln Trp Asp Glu Gln Leu Asp Pro 
 625                630                635                640
Arg Leu Asn Ala Lys Gln Lys Glu Ala Val Leu Ala Ile Thr Thr Pro 
                 645                650                655
Leu Ala Ile Gln Leu Pro Pro Val Leu Ile Ile Gly Pro Tyr Gly Thr 
             660                665                670
Gly Lys Thr Phe Thr Leu Ala Gln Ala Val Lys His Ile Leu Gln Gln 
         675                680                685
Gln Glu Thr Arg Ile Leu Ile Cys Thr His Ser Asn Ser Ala Ala Asp 
     690                695                700
Leu Tyr Ile Lys Asp Tyr Leu His Pro Tyr Val Glu Ala Gly Asn Pro 
 705                710                715                720
Gln Ala Arg Pro Leu Arg Val Tyr Phe Arg Asn Arg Trp Val Lys Thr 
                 725                730                735
Val His Pro Val Val His Gln Tyr Cys Leu Ile Ser Ser Ala His Ser 
             740                745                750
Thr Phe Gln Met Pro Gln Lys Glu Asp Ile Leu Lys His Arg Val Val 
         755                760                765
Val Val Thr Leu Asn Thr Ser Gln Tyr Leu Cys Gln Leu Asp Leu Glu 
     770                775                780
Pro Gly Phe Phe Thr His Ile Leu Leu Asp Glu Ala Ala Gln Ala Met 
 785                790                795                800
Glu Cys Glu Thr Ile Met Pro Leu Ala Leu Ala Thr Gln Asn Thr Arg 
                 805                810                815
Ile Val Leu Ala Gly Asp His Met Gln Leu Ser Pro Phe Val Tyr Ser 
             820                825                830
Glu Phe Ala Arg Glu Arg Asn Leu His Val Ser Leu Leu Asp Arg Leu 
         835                840                845
Tyr Glu His Tyr Pro Ala Glu Phe Pro Cys Arg Ile Leu Leu Cys Glu 
     850                855                860
Asn Tyr Arg Ser His Glu Ala Ile Ile Asn Tyr Thr Ser Glu Leu Phe 
 865                870                875                880
Tyr Glu Gly Lys Leu Met Ala Ser Gly Lys Gln Pro Ala His Lys Asp 
                 885                890                895
Phe Tyr Pro Leu Thr Phe Phe Thr Ala Arg Gly Glu Asp Val Gln Glu 
             900                905                910
Lys Asn Ser Thr Ala Phe Tyr Asn Asn Ala Glu Val Phe Glu Val Val 
         915                920                925
Glu Arg Val Glu Glu Leu Arg Arg Lys Trp Pro Val Ala Trp Gly Lys 
     930                935                940
Leu Asp Asp Gly Ser Ile Gly Val Val Thr Pro Tyr Ala Asp Gln Val 
 945                950                955                960
Phe Arg Ile Arg Ala Glu Leu Arg Lys Lys Arg Leu Ser Asp Val Asn 
                 965                970                975
Val Glu Arg Val Leu Asn Val Gln Gly Lys Gln Phe Arg Val Leu Phe 
             980                985                990
Leu Ser Thr Val Arg Thr Arg His Thr Cys Lys His Lys Gln Thr Pro 
         995                1000                1005
Ile Lys Lys Lys Glu Gln Leu Leu Glu Asp Ser Thr Glu Asp Leu Asp 
     1010                1015                1020
Tyr Gly Phe Leu Ser Asn Tyr Lys Leu Leu Asn Thr Ala Ile Thr Arg 
 1025                1030                1035                1040
Ala Gln Ser Leu Val Ala Val Val Gly Asp Pro Ile Ala Leu Cys Ser 
                 1045                1050                1055
Ile Gly Arg Cys Arg Lys Phe Trp Glu Arg Phe Ile Ala Leu Cys His 
             1060                1065                1070
Glu Asn Ser Ser Leu His Gly Ile Thr Phe Glu Gln Ile Lys Ala Gln 
         1075                1080                1085
Leu Glu Ala Leu Glu Leu Lys Lys Thr Tyr Val Leu Asn Pro Leu Ala 
     1090                1095                1100
Pro Glu Phe Ile Pro Arg Ala Leu Arg Leu Gln His Ser Gly Ser Thr 
 1105                1110                1115                1120
Asn Lys Gln Gln Gln Ser Pro Pro Lys Gly Lys Ser Leu His His Thr 
                 1125                1130                1135
Gln Asn Asp His Phe Gln Asn Asp Gly Ile Val Gln Pro Asn Pro Ser 
             1140                1145                1150
Val Leu Ile Gly Asn Pro Ile Arg Ala Tyr Thr Pro Pro Pro Pro Leu 
         1155                1160                1165
Gly Pro His Pro Asn Leu Gly Lys Ser Pro Ser Pro Val Gln Arg Ile 
     1170                1175                1180
Asp Pro His Thr Gly Thr Ser Ile Leu Tyr Val Pro Ala Val Tyr Gly 
 1185                1190                1195                1200
Gly Asn Val Val Met Ser Val Pro Leu Pro Val Pro Trp Thr Gly Tyr 
                 1205                1210                1215
Gln Gly Arg Phe Ala Val Asp Pro Arg Ile Ile Thr His Gln Ala Ala 
             1220                1225                1230
Met Ala Tyr Asn Met Asn Leu Leu Gln Thr His Gly Arg Gly Ser Pro 
         1235                1240                1245
Ile Pro Tyr Gly Leu Gly His His Pro Pro Val Thr Ile Gly Gln Pro 
     1250                1255                1260
Gln Asn Gln His Gln Glu Lys Asp Gln His Glu Gln Asn Arg Asn Gly 
 1265                1270                1275                1280
Lys Ser Asp Thr Asn Asn Ser Gly Pro Glu Ile Asn Lys Ile Arg Thr 
                 1285                1290                1295
Pro Glu Lys Lys Pro Thr Glu Pro Lys Gln Val Asp Leu Glu Ser Asn 
             1300                1305                1310
Pro Gln Asn Arg Ser Pro Glu Ser Arg Pro Ser Val Val Tyr Pro Ser 
         1315                1320                1325
Thr Lys Phe Pro Arg Lys Asp Asn Leu Asn Pro Arg His Ile Asn Leu 
     1330                1335                1340
Pro Leu Pro Ala Pro His Ala Gln Tyr Ala Ile Pro Asn Arg His Phe 
 1345                1350                1355                1360
His Pro Leu Pro Gln Leu Pro Arg Pro Pro Phe Pro Ile Pro Gln Gln 
                 1365                1370                1375
His Thr Leu Leu Asn Gln Gln Gln Asn Asn Leu Pro Glu Gln Pro Asn 
             1380                1385                1390
Gln Ile Pro Pro Gln Pro Asn Gln Val Val Gln Gln Gln Ser Gln Leu 
         1395                1400                1405
Asn Gln Gln Pro Gln Gln Pro Pro Pro Gln Leu Ser Pro Ala Tyr Gln 
     1410                1415                1420
Ala Gly Pro Asn Asn Ala Phe Phe Asn Ser Ala Val Ala His Arg Pro 
 1425                1430                1435                1440
Gln Ser Pro Pro Ala Glu Ala Val Ile Pro Glu Gln Gln Pro Pro Pro 
                 1445                1450                1455
Met Leu Gln Glu Gly His Ser Pro Leu Arg Ala Ile Ala Gln Pro Gly 
             1460                1465                1470
Pro Ile Leu Pro Ser His Leu Asn Ser Phe Ile Asp Glu Asn Pro Ser 
         1475                1480                1485
Gly Leu Pro Ile Gly Glu Ala Leu Asp Arg Ile His Gly Ser Val Ala 
     1490                1495                1500
Leu Glu Thr Leu Arg Gln Gln Gln Ala Arg Phe Gln Gln Trp Ser Glu 
 1505                1510                1515                1520
His His Ala Phe Leu Ser Gln Gly Ser Val Pro Tyr Pro His His His 
                 1525                1530                1535
His Pro His Leu Gln His Leu Pro Gln Pro Pro Leu Gly Leu His Gln 
             1540                1545                1550
Pro Pro Val Arg Ala Asp Trp Lys Leu Thr Ser Ser Ala Glu Asp Glu 
         1555                1560                1565
Val Glu Thr Thr Tyr Ser Arg Phe Gln Asp Leu Ile Arg Glu Leu Ser 
     1570                1575                1580
His Arg Asp Gln Ser Glu Thr Arg Glu Leu Ala Glu Met Pro Pro Pro 
 1585                1590                1595                1600
Gln Ser Arg Leu Leu Gln Tyr Arg Gln Val Gln Ser Arg Ser Pro Pro 
                 1605                1610                1615
Ala Val Pro Ser Pro Pro Ser Ser Thr Asp His Ser Ser His Phe Ser 
             1620                1625                1630
Asn Phe Asn Asp Asn Ser Arg Asp Ile Glu Val Ala Ser Asn Pro Ala 
         1635                1640                1645
Phe Pro Gln Arg Leu Pro Pro Gln Ile Phe Asn Ser Pro Phe Ser Leu 
     1650                1655                1660
Pro Ser Glu His Leu Ala Pro Pro Pro Leu Lys Tyr Leu Ala Pro Asp 
 1665                1670                1675                1680
Gly Ala Trp Thr Phe Ala Asn Leu Gln Gln Asn His Leu Met Gly Pro 
                 1685                1690                1695
Gly Phe Pro Tyr Gly Leu Pro Pro Leu Pro His Arg Pro Pro Gln Asn 
             1700                1705                1710
Pro Phe Val Gln Ile Gln Asn His Gln His Ala Ile Gly Gln Glu Pro 
         1715                1720                1725
Phe His Pro Leu Ser Ser Arg Thr Val Ser Ser Ser Ser Leu Pro Ser 
     1730                1735                1740
Leu Glu Glu Tyr Glu Pro Arg Gly Pro Gly Arg Pro Leu Tyr Gln Arg 
 1745                1750                1755                1760
Arg Ile Ser Ser Ser Ser Val Gln Pro Cys Ser Glu Glu Val Ser Thr 
                 1765                1770                1775
Pro Gln Asp Ser Leu Ala Gln Cys Lys Glu Leu Gln Asp His Ser Asn 
             1780                1785                1790
Gln Ser Ser Phe Asn Phe Ser Ser Pro Glu Ser Trp Val Asn Thr Thr 
         1795                1800                1805
Ser Ser Thr Pro Tyr Gln Asn Ile Pro Cys Asn Gly Ser Ser Arg Thr 
     1810                1815                1820
Ala Gln Pro Arg Glu Leu Ile Ala Pro Pro Lys Thr Val Lys Pro Pro 
 1825                1830                1835                1840
Glu Asp Gln Leu Lys Ser Glu Asn Leu Glu Val Ser Ser Ser Phe Asn 
                 1845                1850                1855
Tyr Ser Val Leu Gln His Leu Gly Gln Phe Pro Pro Leu Met Pro Asn 
             1860                1865                1870
Lys Gln Ile Ala Glu Ser Ala Asn Ser Ser Ser Pro Gln Ser Ser Ala 
         1875                1880                1885
Gly Gly Lys Pro Ala Met Ser Tyr Ala Ser Ala Leu Arg Ala Pro Pro 
     1890                1895                1900
Lys Pro Arg Pro Pro Pro Glu Gln Ala Lys Lys Ser Ser Asp Pro Leu 
 1905                1910                1915                1920
Ser Leu Phe Gln Glu Leu Ser Leu Gly Ser Ser Ser Gly Ser Asn Gly 
                 1925                1930                1935
Phe Tyr Ser Tyr Phe Lys 
             1940



<210> 5791
<211> 596
<212> DNA
<213> Rattus norvegicus
<308> AA892496
<400> 5791

gatagacag  gtatttaat  cacagaatg  ttttccttc  attacactg  cataaatta  60
aaagtattc  cacttcaca  aataaaacc  tttccagat  attactgac  gtatcaaga  120
gtacagaag  cacaacaaa  acatctgta  agtcgggag  gacggtgac  gcagagagt  180
agccgaact  agtcccgga  gccacgatt  ttcctgcag  gcctggggg  gctgacaga  240
aatcatctc  gcagtctct  ccaccttag  agggcagtt  tcttctggg  actctaaga  300
agtcttgtc  gtgcgtagg  tgtcttaga  aatcaaagg  aagacactg  gactggctt  360
aaaaatcta  atgtacagt  tttgctgtt  taaatattt  acctatgtt  caaaatata  420
agatcttgg  gtggaaatc  catgctaag  taaatataa  caacaggtg  gtctctagt  480
ataaaatca  gttaaatta  cttcagagc  acctttatg  agggaaaac  tttgattaa  540
aacaacctt  tttattcat  acttaataa  aggtttata  aatgaaagt  aggaac  596



<210> 5792
<211> 3004
<212> DNA
<213> Homo sapiens
<308> AK026415
<400> 5792

gtgtgtttg  gtgtgaaat  tgctaataa  gaggagaga  ctctccttt  caatgtgct  60
cggcaggag  aagcaggct  ccggcccct  cctccctga  tcctcagtg  ctgactgga  120
accgcttct  ggggttgct  tgcacatga  tgtttgcta  tgttccagg  gcacgtcgg  180
cttaagaaa  agcacaaaa  aggcccatc  ttattcaga  gccgggccc  ctccatcac  240
caaactggg  ctttcaggt  acatgccgg  ggctgctgc  gacaggacc  agctgcctc  300
aatctgccg  ctaacataa  ctgcggttc  aaaatcctg  cagcacagg  cttcctggg  360
tctgcagag  aaactggaa  gagctggga  ccaggcact  tgttctctg  agaactgtg  420
ctggaaaat  agaaaaagt  tgctgtggt  cggaagtct  agcagggca  gaaacgcca  480
gaactgctg  ccgtagcct  cggggtgaa  gtgggtgtc  aaggcggct  tctttggcc  540
cctctcaaa  tctttgcct  ttcacagat  tcctccctg  ttcgaaggg  tgccctcac  600
cgcaacgac  accacttca  ttatgagaa  acacacaac  ttaaggtcc  cacgttccg  660
ggcccacac  ggtgtgaat  ttgtgccaa  ttcatgtgg  ggctcatcg  ccaaggggt  720
cggtgctca  actgtggat  gaacgtaca  aaacagtgt  ccaagcacg  tcccaatga  780
tgccaacct  atctcaaga  gatcaagaa  gtgtactgt  gtgacctca  aacacttgt  840
aaggctcac  acactcaga  acccatggt  gtagacata  gcattcggg  aattgaagc  900
agaggatta  aatcggaag  cctttacag  gtctctggg  tcactgaac  cattgaaga  960
gtcaaaatg  catttgaca  agatggtga  aaggccgat  tatctgcca  tgtctatcc  1020
gacataaac  tcatcactg  agcccttaa  ctgtatttc  gagacttac  catccctgt  1080
atcacatat  atacctatt  caaatttat  gatgcagca  aaatctcca  tgcagatga  1140
aggctggaa  ccgtccatg  agtgctgat  ctgctgcct  ctgcccact  tgaaaccct  1200
cggtaccta  tgatccacc  caaaaaggt  actatgaat  aaaaagaca  tttcatgaa  1260
gcagaaaat  tggggatcg  gtttgggcc  actctgatg  ggccccctg  ggacagcac  1320
ctgaccacc  tgcatgata  gcggtacca  aagctgatt  tgcagattt  aatagaaaa  1380
gaagacgtt  tattctaat  catcaggga  atgagctga  tggccccag  accatccaa  1440
ttgacacag  taaaggaat  aaaacattt  ttaccactt  atttgtttt  caagcaagt  1500
ctagaattt  ctggactgc  gaggatcgc  gagtggggt  ctgtgtctc  tagacatgc  1560
ccacctcca  gtgagaaca  gggtgaagg  gagggaagc  cctcacctt  ggtcttttg  1620
tgtgcctcc  atgtatgtc  ggtttgctg  aagagtgat  aatacatct  taatttatt  1680
aaaaacaat  tagaccttt  aacttcagt  ttattggta  taaaaggga  cttaattca  1740
acaggtact  gatacagtt  tacattttc  acttacaaa  agaagacaa  tctgttaaa  1800
gaaacctgt  tcgtaaaat  tatttttat  ttacccacg  gaatgttgt  atttttagc  1860
aatagaact  aatgcagtg  attggttat  accctgtgt  ccttgtccc  cattttgct  1920
tgacaccct  aaaaagctg  ccacaaatg  agtattatc  tgacatacc  ctgtcctcc  1980
cagtgcttt  taatgaaat  tcacctgcc  cttgtgttc  tgctttgga  agtttttgc  2040
cttaagcat  ggcattctt  tattgtatg  tatgtattt  tagcaattg  aggatggtc  2100
gaaatgtcc  cacactttc  atgcataca  attttgtga  ttcccaaag  atgctttgg  2160
attggtcat  gtcttttcg  atcatgagt  tgtatccca  aagatacag  atgcggtca  2220
tttacctga  attatttga  aacactgga  gtatctggt  tgtgtaaaa  gttagcact  2280
ttaccctct  ttcttcctg  ccaagccct  tgaattcat  tgttaatat  aaattgtat  2340
tttgccaca  ttctgtatt  gtgaaaagc  aatctgcag  ataactgcc  acgtttttc  2400
ttcttgttt  acaaaccta  tttttaaag  gagaataag  ttggttttt  ccaaatatt  2460
gttcctcct  gacaaaagt  gctctgtgt  gataatatg  ttttattac  acagttcca  2520
tcacttggt  atatttatc  tagcatgag  ctttcacac  aagatttct  tattttgta  2580
cataggtga  atatttaaa  catcaaaaa  tgtaaatct  gatttttaa  aaatccaac  2640
gcaatgtct  ttcctttga  tgagatgat  tgtgtaaac  ctccagtct  gctttggag  2700
gagcagaag  gaatgacta  tttacgtgg  gcatcattg  gtgactgtt  acctggaca  2760
tcccaaggg  tatgcagat  gactccatt  gcacaggga  gtttgacct  ttccctgct  2820
ttatccctc  tcccaactg  acagatttg  ttgtcgtag  ttatgtact  cttgatact  2880
tcaaaaaat  atctggaaa  ggttttatt  tgtgaagtg  acaatactt  gtaatttat  2940
atagtgtaa  tggaaggca  agcatcaca  gtattaaat  cttcctgtc  ttaaaaaaa  3000
aaaa  3004



<210> 5793
<211> 468
<212> PRT
<213> Homo sapiens
<308> P52757
<400> 5793

Met Ala Ala Ser Ser Asn Ser Ser Leu Ser Gly Ser Ser Val Ser Ser 
  1               5                  10                  15
Asp Ala Glu Glu Tyr Gln Pro Pro Ile Trp Lys Ser Tyr Leu Tyr Gln 
             20                  25                  30
Leu Gln Gln Glu Ala Pro Arg Pro Lys Arg Ile Ile Cys Pro Arg Glu 
         35                  40                  45
Val Glu Asn Arg Pro Lys Tyr Tyr Gly Arg Glu Phe His Gly Ile Ile 
     50                  55                  60
Ser Arg Glu Gln Ala Asp Glu Leu Leu Gly Gly Val Glu Gly Ala Tyr 
 65                  70                  75                  80
Ile Leu Arg Glu Ser Gln Arg Gln Pro Gly Cys Tyr Thr Leu Ala Leu 
                 85                  90                  95
Arg Phe Gly Asn Gln Thr Leu Asn Tyr Arg Leu Phe His Asp Gly Lys 
             100                105                110
His Phe Val Gly Glu Lys Arg Phe Glu Ser Ile His Asp Leu Val Thr 
         115                120                125
Asp Gly Leu Ile Thr Leu Tyr Ile Glu Thr Lys Ala Ala Glu Tyr Ile 
     130                135                140
Ser Lys Met Thr Thr Asn Pro Ile Tyr Glu His Ile Gly Tyr Ala Thr 
 145                150                155                160
Leu Leu Arg Glu Lys Val Ser Arg Arg Leu Ser Arg Ser Lys Asn Glu 
                 165                170                175
Pro Arg Lys Thr Asn Val Thr His Glu Glu His Thr Ala Val Glu Lys 
             180                185                190
Ile Ser Ser Leu Val Arg Arg Ala Ala Leu Thr His Asn Asp Asn His 
         195                200                205
Phe Asn Tyr Glu Lys Thr His Asn Phe Lys Val His Thr Phe Arg Gly 
     210                215                220
Pro His Trp Cys Glu Tyr Cys Ala Asn Phe Met Trp Gly Leu Ile Ala 
 225                230                235                240
Gln Gly Val Arg Cys Ser Asp Cys Gly Leu Asn Val His Lys Gln Cys 
                 245                250                255
Ser Lys His Val Pro Asn Asp Cys Gln Pro Asp Leu Lys Arg Ile Lys 
             260                265                270
Lys Val Tyr Cys Cys Asp Leu Thr Thr Leu Val Lys Ala His Asn Thr 
         275                280                285
Gln Arg Pro Met Val Val Asp Ile Cys Ile Arg Glu Ile Glu Ala Arg 
     290                295                300
Gly Leu Lys Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Thr Glu His 
 305                310                315                320
Ile Glu Asp Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala Asp 
                 325                330                335
Ile Ser Ala Asn Val Tyr Pro Asp Ile Asn Ile Ile Thr Gly Ala Leu 
             340                345                350
Lys Leu Tyr Phe Arg Asp Leu Pro Ile Pro Val Ile Thr Tyr Asp Thr 
         355                360                365
Tyr Ser Lys Phe Ile Asp Ala Ala Lys Ile Ser Asn Ala Asp Glu Arg 
     370                375                380
Leu Glu Ala Val His Glu Val Leu Met Leu Leu Pro Pro Ala His Tyr 
 385                390                395                400
Glu Thr Leu Arg Tyr Leu Met Ile His Leu Lys Lys Val Thr Met Asn 
                 405                410                415
Glu Lys Asp Asn Phe Met Asn Ala Glu Asn Leu Gly Ile Val Phe Gly 
             420                425                430
Pro Thr Leu Met Arg Pro Pro Glu Asp Ser Thr Leu Thr Thr Leu His 
         435                440                445
Asp Met Arg Tyr Gln Lys Leu Ile Val Gln Ile Leu Ile Glu Asn Glu 
     450                455                460
Asp Val Leu Phe 
 465



<210> 5794
<211> 590
<212> DNA
<213> Rattus norvegicus
<308> AA892500
<400> 5794

accctaaaa  cactgtcag  tttatttaa  cttgatata  atttgtaca  gcaatttaa  60
aagactatt  cacaacgac  cagtgggtt  tacctggtt  gaagataat  cagttacaa  120
tgagaggta  aaacaccgt  gtaaagacc  aaaaataca  acatcctat  cataaacgt  180
caaattaac  gctagaatt  catacagat  aataatgta  aaattacat  actttgttc  240
ccaagtaaa  gaaaaccat  ttctctgtt  actttaatc  gcacactaa  gtaagtgtg  300
tgccaaaga  cttctgtgc  gctatcaga  cgcaggtca  tatgtcaaa  ttttgaagt  360
aaaagatta  aaccggtga  tggtttatt  aagtattaa  gcaggtaag  aaaagaaac  420
aaataatat  caacataga  accattctt  gggagatgt  gatctgcca  gaccagcta  480
ttgtgaact  agggttaac  ctgagaagt  cacattagt  tggagagag  tgcccattt  540
tctaaggga  aacaaacct  atttcttac  attttatgt  gaaactccac  590



<210> 5795
<211> 1037
<212> PRT
<213> Rattus norvegicus
<308> BAA77341
<400> 5795

Met Glu Val Val Gly Asp Phe Glu Tyr Cys Lys Arg Asp Leu Val Gly 
  1               5                  10                  15
His Gly Ala Phe Ala Val Val Phe Arg Gly Arg His Arg Gln Lys Thr 
             20                  25                  30
Asp Trp Glu Val Ala Ile Lys Ser Ile Asn Lys Lys Asn Leu Ser Lys 
         35                  40                  45
Ser Gln Ile Leu Leu Gly Lys Glu Ile Lys Ile Leu Lys Glu Leu Gln 
     50                  55                  60
His Glu Asn Ile Val Ala Leu Tyr Asp Val Gln Glu Leu Pro Asn Ser 
 65                  70                  75                  80
Val Phe Leu Val Met Glu Tyr Cys Asn Gly Gly Asp Leu Ala Asp Tyr 
                 85                  90                  95
Leu Gln Ala Lys Gly Thr Leu Ser Glu Asp Thr Ile Arg Val Phe Leu 
             100                105                110
His Gln Ile Ala Ala Ala Met Arg Ile Leu His Ser Lys Gly Ile Ile 
         115                120                125
His Arg Asp Leu Lys Pro Gln Asn Ile Leu Leu Ser Tyr Ala Asn Arg 
     130                135                140
Arg Lys Ser Asn Val Ser Gly Ile Arg Ile Lys Ile Ala Asp Phe Gly 
 145                150                155                160
Phe Ala Arg Tyr Leu His Ser Asn Thr Met Ala Ala Thr Leu Cys Gly 
                 165                170                175
Ser Pro Met Tyr Met Ala Pro Glu Val Ile Met Ser Gln His Tyr Asp 
             180                185                190
Ala Lys Ala Asp Leu Trp Ser Ile Gly Thr Val Ile Tyr Gln Cys Leu 
         195                200                205
Val Gly Lys Pro Pro Phe Gln Ala Asn Ser Pro Gln Asp Leu Arg Met 
     210                215                220
Phe Tyr Glu Lys Asn Arg Ser Leu Met Pro Ser Ile Pro Arg Glu Thr 
 225                230                235                240
Ser Pro Tyr Leu Ala Asn Leu Leu Leu Gly Leu Leu Gln Arg Asn Gln 
                 245                250                255
Lys Asp Arg Met Asp Phe Glu Ala Phe Phe Ser His Pro Phe Leu Glu 
             260                265                270
Gln Val Pro Val Lys Lys Ser Cys Pro Val Pro Val Pro Val Tyr Ser 
         275                280                285
Gly Pro Val Pro Gly Ser Ser Cys Ser Ser Ser Pro Ser Cys Arg Phe 
     290                295                300
Ala Ser Pro Pro Ser Leu Pro Asp Met Gln His Ile Gln Glu Glu Asn 
 305                310                315                320
Leu Ser Ser Pro Pro Leu Gly Pro Pro Asn Tyr Leu Gln Val Ser Lys 
                 325                330                335
Asp Ser Ala Ser Asn Ser Ser Lys Asn Ser Ser Cys Asp Thr Asp Asp 
             340                345                350
Phe Val Leu Val Pro His Asn Ile Ser Ser Asp His Ser Tyr Asp Met 
         355                360                365
Pro Met Gly Thr Thr Ala Arg Arg Ala Ser Asn Glu Phe Phe Met Cys 
     370                375                380
Gly Gly Gln Cys Gln Pro Thr Val Ser Pro His Ser Glu Thr Ala Pro 
 385                390                395                400
Ile Pro Val Pro Thr Gln Val Arg Asn Tyr Gln Arg Ile Glu Gln Asn 
                 405                410                415
Leu Ile Ser Thr Ala Ser Ser Gly Thr Asn Pro His Gly Ser Pro Arg 
             420                425                430
Ser Ala Val Val Arg Arg Ser Asn Thr Ser Pro Met Gly Phe Leu Arg 
         435                440                445
Val Gly Ser Cys Ser Pro Val Pro Gly Asp Thr Val Gln Thr Gly Gly 
     450                455                460
Arg Arg Leu Ser Thr Gly Ser Ser Arg Pro Tyr Ser Pro Ser Pro Leu 
 465                470                475                480
Val Gly Thr Ile Pro Glu Gln Phe Ser Gln Cys Cys Cys Gly His Pro 
                 485                490                495
Gln Gly His Glu Ala Arg Ser Arg His Ser Ser Gly Ser Pro Val Pro 
             500                505                510
Gln Thr Gln Ala Pro Gln Ser Leu Leu Leu Gly Ala Arg Leu Gln Ser 
         515                520                525
Ala Pro Thr Leu Thr Asp Ile Tyr Gln Asn Lys Gln Lys Leu Arg Lys 
     530                535                540
Gln His Ser Asp Pro Val Cys Pro Ser His Ala Gly Ala Gly Tyr Ser 
 545                550                555                560
Tyr Ser Pro Gln Pro Ser Arg Pro Gly Ser Leu Gly Thr Ser Pro Thr 
                 565                570                575
Lys His Thr Gly Ser Ser Pro Arg Asn Ser Asp Trp Phe Phe Lys Thr 
             580                585                590
Pro Leu Pro Thr Ile Ile Gly Ser Pro Thr Lys Thr Thr Ala Pro Phe 
         595                600                605
Lys Ile Pro Lys Thr Gln Ala Ser Ser Asn Leu Leu Ala Leu Val Thr 
     610                615                620
Arg His Gly Pro Ala Glu Ser Gln Ser Lys Asp Gly Asn Asp Pro Arg 
 625                630                635                640
Glu Cys Ser His Cys Leu Ser Val Gln Gly Ser Glu Arg His Arg Ser 
                 645                650                655
Glu Gln Gln Gln Ser Lys Ala Val Phe Gly Arg Ser Val Ser Thr Gly 
             660                665                670
Lys Leu Ser Glu Gln Gln Val Lys Ala Pro Leu Gly Gly His Gln Gly 
         675                680                685
Ser Thr Asp Ser Leu Asn Thr Glu Arg Pro Met Asp Val Ala Pro Ala 
     690                695                700
Gly Ala Cys Gly Val Met Leu Ala Leu Pro Ala Gly Thr Ala Ala Ser 
 705                710                715                720
Ala Arg Ala Val Leu Phe Thr Val Gly Ser Pro Pro His Ser Ala Thr 
                 725                730                735
Ala Pro Thr Cys Thr His Met Val Leu Arg Thr Arg Thr Thr Ser Val 
             740                745                750
Gly Ser Ser Ser Ser Gly Gly Ser Leu Cys Ser Ala Ser Gly Arg Val 
         755                760                765
Cys Val Gly Ser Pro Pro Gly Pro Gly Leu Gly Ser Ser Pro Pro Gly 
     770                775                780
Ala Glu Gly Ala Pro Ser Leu Arg Tyr Val Pro Tyr Gly Ala Ser Pro 
 785                790                795                800
Pro Ser Leu Glu Gly Leu Ile Thr Phe Glu Ala Pro Glu Leu Pro Glu 
                 805                810                815
Glu Thr Leu Met Glu Arg Glu His Thr Asp Thr Leu Arg His Leu Asn 
             820                825                830
Met Met Leu Met Phe Thr Glu Cys Val Leu Asp Leu Thr Ala Val Arg 
         835                840                845
Gly Gly Asn Pro Glu Leu Cys Thr Ser Ala Val Ser Leu Tyr Gln Ile 
     850                855                860
Gln Glu Ser Val Val Val Asp Gln Ile Ser Gln Leu Ser Lys Asp Trp 
 865                870                875                880
Gly Arg Val Glu Gln Leu Val Leu Tyr Met Lys Ala Ala Gln Leu Leu 
                 885                890                895
Ala Ala Ser Leu His Leu Ala Lys Ala Gln Val Lys Ser Gly Lys Leu 
             900                905                910
Ser Pro Ser Met Ala Val Lys Gln Val Val Lys Asn Leu Asn Glu Arg 
         915                920                925
Tyr Lys Phe Cys Ile Thr Met Cys Lys Lys Leu Thr Glu Lys Leu Asn 
     930                935                940
Arg Phe Phe Ser Asp Lys Gln Arg Phe Ile Asp Glu Ile Asn Ser Val 
 945                950                955                960
Thr Ala Glu Lys Leu Ile Tyr Asn Cys Ala Val Glu Met Val Gln Ser 
                 965                970                975
Ala Ala Leu Asp Glu Met Phe Gln Gln Thr Glu Asp Ile Val Tyr Arg 
             980                985                990
Tyr His Lys Ala Ala Val Leu Leu Glu Gly Leu Ser Lys Ile Leu Gln 
         995                1000                1005
Asp Pro Thr Asp Val Glu Asn Val His Lys Tyr Lys Cys Ser Ile Glu 
     1010                1015                1020
Arg Arg Leu Ser Ala Leu Cys Cys Ser Thr Ala Thr Val 
 1025                1030                1035



<210> 5796
<211> 5808
<212> DNA
<213> Homo sapiens
<308> AB014523
<400> 5796

gcgcgcgcg  gggcgttgg  cgccgccgc  aggcgggga  gcgcggggc  gcggcggtg  60
gggttctag  gcggcggcc  tcgccgtcg  agcagcgcc  cgagcgggg  gggccgagg  120
ggcccgacg  gctggggat  gagagtacc  ggcccctca  tgcctcaga  cgcgtgtgc  180
gctctgggc  cgcacagtg  cggtgacgg  acccctggc  cggcagcgc  gaggccgct  240
cgccagaca  ccagcggcc  gcggcaggc  gggccatga  cggcagggg  cgggccggg  300
ctcgctgac  ctggctccg  gcggcagct  ccccagttt  cgctccggt  tctcggcat  360
agagtccgc  cgggcccgg  gctgcggct  ccccagacc  gccgcacgc  ggcgcgctc  420
gggcccgcg  agccgcggt  ctgatacct  cgccgcact  cgccgcccg  ccgtccgct  480
tgtgccccg  gggcgcggc  atggaggtg  tgggtgact  cgagtacag  aagagggat  540
tcgtgggac  cggggcctt  gccgtggtc  tccgggggc  gcaccgcca  aaaactgat  600
gggaggtag  tattaaaag  attaataaa  agaacttgt  aaaatcaca  atactgctt  660
gaaaggaaa  taaaatctt  aaggaactt  agcatgaaa  tattgtagc  ctctatgat  720
ttcaggaat  acccaactc  gtctttttg  tgatggagt  ttgcaatgg  ggagacctc  780
cagattatt  gcaagcgaa  gggactctc  gtgaagaca  gatcagagt  tttctgcat  840
agattgctg  tgccatgcg  atcctgcac  gcaaaggaa  catccacag  gatctcaaa  900
cacagaaca  cttgctgtc  tatgccaat  gcagaaaat  aagtgtcag  ggtattcgc  960
tcaaaatag  ggattttgg  tttgctcgt  acctacata  taacatgat  gctgcaaca  1020
tgtgtggat  cccgatgta  atggctcct  aggttatta  gtctcaaca  tatgatgct  1080
aggctgact  gtggagcat  ggaacagtg  tataccaat  cctagttgg  aaaccacct  1140
ttcaggcca  tagtcctca  gacttaagg  tgttttatg  aaaaaacag  agcttaatg  1200
ctagtattc  cagagaaac  tcaccttat  tggctaatc  ccttttggg  ttgcttcag  1260
gaaaccaaa  agatagaat  gactttgaa  cgtttttta  ccatccttt  cttgagcaa  1320
gtccagtaa  aaaatcttg  ccagttcca  tgcccatgt  ttctggttc  gtctctgga  1380
gctcctgtg  cagctctcc  tcttgtcgt  ttgcttctc  accatccct  ccagatatg  1440
agcatattc  ggaagaaaa  ttatcttcc  caccattgg  tcctcccaa  tatctacaa  1500
tttccaaag  ttctgccag  actagtagc  agaactctt  ttgtgacac  gatgacttt  1560
ttttggtgc  acacaacat  tcgtcagac  actcatgtg  tatgccaat  gggactgct  1620
gcagacgtg  ttcaaatga  ttcttggtg  gtggagggc  gtgtcagcc  actgtgtca  1680
ctcacagcg  aacagcacc  attccagtt  ctactcaaa  aaggaatta  cagcgcata  1740
agcagaatc  tacatctac  gccagctca  gcacaaatg  acatggttc  ccaagatct  1800
cagtggtac  aaggtccaa  accagcccc  tgggcttcc  ccggccggg  tcatgctcc  1860
cagtaccag  agacacagc  cagacagtt  gacgaaggc  ctccactgg  tcttctagg  1920
cttactcac  ttccccttt  gttggtacc  ttcctgagc  attcagtca  tgctgctgt  1980
ggcatcctc  gggccatga  tccaggagt  gaaactcct  aggttctcc  gtgccacaa  2040
ctcagtccc  acagtctct  ttatcgggt  ctagactgc  gagcgcccc  accctcact  2100
acatctatc  gaacaagca  aagctcaga  aacagcact  tgaccccgt  tgcccatcc  2160
atactgggg  tgggtacag  tactcgcct  agcccagtc  gcctggcag  cttggaact  2220
ctcccacca  gcacttggg  tcctctcca  ggagttctg  ctggttctt  aaaactcct  2280
tgccaacaa  cattggctc  cctactaag  ccacagctc  tttcaaaat  cctaaaact  2340
aagcatctt  caacctgtt  gccttggtt  ctcgtcatg  gcctgctga  gaacagtcg  2400
aagatggga  tgagccacg  gaatgtgcc  attgcctct  agtgcaagg  agtgagagg  2460
agcgggccg  gcagcagag  aaggcagtg  ttggcagat  tgtcagtac  gggaagtta  2520
cagatcaac  aggaaagac  cctatatgt  gacatcagg  cagcacaga  agtttaaat  2580
cagaacgac  aatggatat  gctccggca  gagcctgtg  tggtgttct  gcacctcct  2640
caggtacag  agcaagttc  aaggctgtc  tcttcactg  agggtctcc  ccacacagt  2700
cggcagccc  cacttgtac  cacatgttc  ttcgaacaa  aacaacctc  gtggggccc  2760
gcaactccg  gggctctct  tgtgccatg  gtggccgcg  gtgcgtggg  tccccgcct  2820
gcccaggct  cggctcttc  cctccagga  cagaggcag  tcccagcct  agatacgtg  2880
cttacggtg  ttcaccccc  agcctagag  ggctcatca  ctttgaagc  cctgaactg  2940
cggaggaga  gctgatgga  cgggaacac  cagacacct  acgccatct  aatgtgatg  3000
tgatgttca  tgagtgtgt  ctggacctg  cagccatga  gggaggaaa  cctgagctg  3060
gcacatctg  tgtgtcctt  taccagatc  aggagagtg  ggtggtgga  cagatcagt  3120
agctgagca  agactgggg  cgggtggag  agctggtgt  gtacatgaa  gcagcacag  3180
tgcttgcgg  ttctctgca  cttgccaaa  cccagatca  gtccgggaa  ctgagccca  3240
ccacagctg  gaaacaagt  gtcaagaat  tgaacgaac  atataaatt  tgcatcacc  3300
tgcgcaaga  acttacaga  aagctgaat  gattcttct  tgacaaaca  aggtttatt  3360
atgaaatca  cagtgtgac  gcagagaaa  tcatctata  ttgtgctgt  gaaatggtt  3420
agtctgcag  cctggatga  atgtttcag  agaccgaag  tattgttta  cgctatcat  3480
aggcagccc  tcttttgga  ggcctaagt  ggattctac  ggaccctgc  gatattgaa  3540
atgtgcata  atataaatg  agtattgag  gaagactgt  ggcgctctg  catagcacc  3600
caaccgtgt  agcagcagg  tcatcccgt  gaccggtgg  gggaacgtg  ggtgatgcc  3660
ttgggatta  agcttgagt  ctgtcaccc  atccccagg  aactgtagc  tcttaactg  3720
tgactacca  agaacaagc  gtgatttga  aaaggaaaa  caatccaaa  actacatat  3780
tgtaggaaa  ctgccttat  ggagaaaat  accctttcc  tttttcttt  tagaagcag  3840
agcaagagt  tttggctcc  agtttggac  tggtgaata  atgtacctt  gaactagga  3900
aatcggtac  gttattctt  aagataatt  aaaatgaaa  aaagtgagt  ctcgtcact  3960
ggttcatca  agcagtgtg  gaaattcca  gtgtttgct  aggtgtaaa  gtaaatgta  4020
tcacccctc  tccaggcag  ttgatattt  gagtaagtt  gtttaaatc  gagcatgca  4080
ctttaaaca  ctcaggaag  aatagctta  gaagaagtg  aacatggat  ttggaagaa  4140
ttttgaaat  ttcaatttg  tcctaatat  gatacatgt  aatcttcca  aatctttca  4200
attgcacta  tttattaaa  caactgtgt  ttggatttt  taatttaac  aaggcacaa  4260
ggacttgtt  aaaatattt  acttgattg  atacataga  cctttccag  attcacatg  4320
aatctccag  gaactttta  gtggttaaa  cttgtattc  tgtgaacct  tgcacattt  4380
ttttttttt  cttctttat  tacacctac  gattttctc  gtaatgttt  tgttagctt  4440
tggttccat  ttttattgt  catgcagaa  gtacattga  gcctgtgac  ttaggttta  4500
taaaggcta  gtttatttg  gcagtatta  aaacaaaat  atggatcaa  agatactct  4560
gataatttg  atagggcca  aacaaagtt  gtgacctaa  ggcttgtta  tgatgtgga  4620
ttcctacat  cagtgagtg  aaaatgaag  tcgttttct  ttaggaaaa  gggcagctg  4680
cttctgcct  atgtgtatt  ttcatgtta  ttctgacag  tcaccaaat  gctagtcat  4740
gagaatgca  gcagttaac  taatatccc  ccaggaatg  ttcctacgt  gtgtattat  4800
tggtttctt  tacttacct  cttgaatac  tgaataaac  attcaccaa  tttaatcct  4860
ttattttaa  ccttttaca  aaaataatc  gaactcttt  acaaattgc  cagagctct  4920
tggcattaa  ctaatttta  tgtactgat  aaaacaaac  tggttgtcc  ttactttga  4980
aaagtaatg  aatttttac  ttatttatc  gtatgaaat  ccagtagtt  atttgaaca  5040
ttatttata  gacgtttgt  tttttaggt  tttaataca  tgtttctac  tctcatttg  5100
aactgcatg  attattctt  aaactaggt  aaactcact  aattgttgt  taatagcct  5160
tttattatt  cctgtacaa  tgtatatta  ggtaaaata  aactgacaa  gtgtttcta  5220
ggtgtagct  ggtacatat  aagtggctt  ttgagccag  tacttcctt  gtgagttta  5280
agacttggc  atgaatatc  tttgtcctg  cccaggatt  agatcttgg  tactgtcat  5340
caggcttcc  ggaacatag  ctgttttac  tccacaacc  tatttgtta  tagtgatac  5400
ttattttat  taatatttt  tattcacag  gaaatttca  tcatgttct  tcagttatc  5460
cctgtgtta  ctcagttgt  ggtttattc  atcctctcc  cttcctctc  catttcttt  5520
ttaacacag  atgaaacag  ttcagagag  ggaagtgat  ggcctaaag  caggaacta  5580
gcaagtggt  aagccatgc  ttgtgactt  caagttaat  cttcttgtt  ttgtatatt  5640
aaggtcttg  ggtagatgg  gtgtgtgaa  cagtgaagt  tcaacagca  aaaagaaca  5700
aatgtaaat  catgaataa  ggttctggt  atacttcca  tatcaaggc  aattaagag  5760
ttttgcctt  agtatagca  taataaaca  atgctttat  tttccctg  5808



<210> 5797
<211> 1036
<212> PRT
<213> Homo sapiens
<308> XP_008514
<400> 5797

Met Glu Val Val Gly Asp Phe Glu Tyr Ser Lys Arg Asp Leu Val Gly 
  1               5                  10                  15
His Gly Ala Phe Ala Val Val Phe Arg Gly Arg His Arg Gln Lys Thr 
             20                  25                  30
Asp Trp Glu Val Ala Ile Lys Ser Ile Asn Lys Lys Asn Leu Ser Lys 
         35                  40                  45
Ser Gln Ile Leu Leu Gly Lys Glu Ile Lys Ile Leu Lys Glu Leu Gln 
     50                  55                  60
His Glu Asn Ile Val Ala Leu Tyr Asp Val Gln Glu Leu Pro Asn Ser 
 65                  70                  75                  80
Val Phe Leu Val Met Glu Tyr Cys Asn Gly Gly Asp Leu Ala Asp Tyr 
                 85                  90                  95
Leu Gln Ala Lys Gly Thr Leu Ser Glu Asp Thr Ile Arg Val Phe Leu 
             100                105                110
His Gln Ile Ala Ala Ala Met Arg Ile Leu His Ser Lys Gly Ile Ile 
         115                120                125
His Arg Asp Leu Lys Pro Gln Asn Ile Leu Leu Ser Tyr Ala Asn Arg 
     130                135                140
Arg Lys Ser Ser Val Ser Gly Ile Arg Ile Lys Ile Ala Asp Phe Gly 
 145                150                155                160
Phe Ala Arg Tyr Leu His Ser Asn Met Met Ala Ala Thr Leu Cys Gly 
                 165                170                175
Ser Pro Met Tyr Met Ala Pro Glu Val Ile Met Ser Gln His Tyr Asp 
             180                185                190
Ala Lys Ala Asp Leu Trp Ser Ile Gly Thr Val Ile Tyr Gln Cys Leu 
         195                200                205
Val Gly Lys Pro Pro Phe Gln Ala Asn Ser Pro Gln Asp Leu Arg Met 
     210                215                220
Phe Tyr Glu Lys Asn Arg Ser Leu Met Pro Ser Ile Pro Arg Glu Thr 
 225                230                235                240
Ser Pro Tyr Leu Ala Asn Leu Leu Leu Gly Leu Leu Gln Arg Asn Gln 
                 245                250                255
Lys Asp Arg Met Asp Phe Glu Ala Phe Phe Ser His Pro Phe Leu Glu 
             260                265                270
Gln Gly Pro Val Lys Lys Ser Cys Pro Val Pro Val Pro Met Tyr Ser 
         275                280                285
Gly Ser Val Ser Gly Ser Ser Cys Gly Ser Ser Pro Ser Cys Arg Phe 
     290                295                300
Ala Ser Pro Pro Ser Leu Pro Asp Met Gln His Ile Gln Glu Glu Asn 
 305                310                315                320
Leu Ser Ser Pro Pro Leu Gly Pro Pro Asn Tyr Leu Gln Val Ser Lys 
                 325                330                335
Asp Ser Ala Ser Thr Ser Ser Lys Asn Ser Ser Cys Asp Thr Asp Asp 
             340                345                350
Phe Val Leu Val Pro His Asn Ile Ser Ser Asp His Ser Cys Asp Met 
         355                360                365
Pro Val Gly Thr Ala Gly Arg Arg Ala Ser Asn Glu Phe Leu Val Cys 
     370                375                380
Gly Gly Gln Cys Gln Pro Thr Val Ser Pro His Ser Glu Thr Ala Pro 
 385                390                395                400
Ile Pro Val Pro Thr Gln Ile Arg Asn Tyr Gln Arg Ile Glu Gln Asn 
                 405                410                415
Leu Thr Ser Thr Ala Ser Ser Gly Thr Asn Val His Gly Ser Pro Arg 
             420                425                430
Ser Ala Val Val Arg Arg Ser Asn Thr Ser Pro Met Gly Phe Leu Arg 
         435                440                445
Pro Gly Ser Cys Ser Pro Val Pro Ala Asp Thr Ala Gln Thr Val Gly 
     450                455                460
Arg Arg Leu Ser Thr Gly Ser Ser Arg Pro Tyr Ser Pro Ser Pro Leu 
 465                470                475                480
Val Gly Thr Ile Pro Glu Gln Phe Ser Gln Cys Cys Cys Gly His Pro 
                 485                490                495
Gln Gly His Asp Ser Arg Ser Arg Asn Ser Ser Gly Ser Pro Val Pro 
             500                505                510
Gln Ala Gln Ser Pro Gln Ser Leu Leu Ser Gly Ala Arg Leu Gln Ser 
         515                520                525
Ala Pro Thr Leu Thr Asp Ile Tyr Gln Asn Lys Gln Lys Leu Arg Lys 
     530                535                540
Gln His Ser Asp Pro Val Cys Pro Ser His Thr Gly Ala Gly Tyr Ser 
 545                550                555                560
Tyr Ser Pro Gln Pro Ser Arg Pro Gly Ser Leu Gly Thr Ser Pro Thr 
                 565                570                575
Lys His Leu Gly Ser Ser Pro Arg Ser Ser Asp Trp Phe Phe Lys Thr 
             580                585                590
Pro Leu Pro Thr Ile Ile Gly Ser Pro Thr Lys Thr Thr Ala Pro Phe 
         595                600                605
Lys Ile Pro Lys Thr Gln Ala Ser Ser Asn Leu Leu Ala Leu Val Thr 
     610                615                620
Arg His Gly Pro Ala Glu Glu Gln Ser Lys Asp Gly Asn Glu Pro Arg 
 625                630                635                640
Glu Cys Ala His Cys Leu Leu Val Gln Gly Ser Glu Arg Gln Arg Ala 
                 645                650                655
Glu Gln Gln Ser Lys Ala Val Phe Gly Arg Ser Val Ser Thr Gly Lys 
             660                665                670
Leu Ser Asp Gln Gln Gly Lys Thr Pro Ile Cys Arg His Gln Gly Ser 
         675                680                685
Thr Asp Ser Leu Asn Thr Glu Arg Pro Met Asp Ile Ala Pro Ala Gly 
     690                695                700
Ala Cys Gly Gly Val Leu Ala Pro Pro Ala Gly Thr Ala Ala Ser Ser 
 705                710                715                720
Lys Ala Val Leu Phe Thr Val Gly Ser Pro Pro His Ser Ala Ala Ala 
                 725                730                735
Pro Thr Cys Thr His Met Phe Leu Arg Thr Arg Thr Thr Ser Val Gly 
             740                745                750
Pro Ser Asn Ser Gly Gly Ser Leu Cys Ala Met Ser Gly Arg Val Cys 
         755                760                765
Val Gly Ser Pro Pro Gly Pro Gly Phe Gly Ser Ser Pro Pro Gly Ala 
     770                775                780
Glu Ala Ala Pro Ser Leu Arg Tyr Val Pro Tyr Gly Ala Ser Pro Pro 
 785                790                795                800
Ser Leu Glu Gly Leu Ile Thr Phe Glu Ala Pro Glu Leu Pro Glu Glu 
                 805                810                815
Thr Leu Met Glu Arg Glu His Thr Asp Thr Leu Arg His Leu Asn Val 
             820                825                830
Met Leu Met Phe Thr Glu Cys Val Leu Asp Leu Thr Ala Met Arg Gly 
         835                840                845
Gly Asn Pro Glu Leu Cys Thr Ser Ala Val Ser Leu Tyr Gln Ile Gln 
     850                855                860
Glu Ser Val Val Val Asp Gln Ile Ser Gln Leu Ser Lys Asp Trp Gly 
 865                870                875                880
Arg Val Glu Gln Leu Val Leu Tyr Met Lys Ala Ala Gln Leu Leu Ala 
                 885                890                895
Ala Ser Leu His Leu Ala Lys Ala Gln Ile Lys Ser Gly Lys Leu Ser 
             900                905                910
Pro Ser Thr Ala Val Lys Gln Val Val Lys Asn Leu Asn Glu Arg Tyr 
         915                920                925
Lys Phe Cys Ile Thr Met Cys Lys Lys Leu Thr Glu Lys Leu Asn Arg 
     930                935                940
Phe Phe Ser Asp Lys Gln Arg Phe Ile Asp Glu Ile Asn Ser Val Thr 
 945                950                955                960
Ala Glu Lys Leu Ile Tyr Asn Cys Ala Val Glu Met Val Gln Ser Ala 
                 965                970                975
Ala Leu Asp Glu Met Phe Gln Gln Thr Glu Asp Ile Val Tyr Arg Tyr 
             980                985                990
His Lys Ala Ala Leu Leu Leu Glu Gly Leu Ser Arg Ile Leu Gln Asp 
         995                1000                1005
Pro Ala Asp Ile Glu Asn Val His Lys Tyr Lys Cys Ser Ile Glu Arg 
     1010                1015                1020
Arg Leu Ser Ala Leu Cys His Ser Thr Ala Thr Val 
 1025                1030                1035



<210> 5798
<211> 590
<212> DNA
<213> Rattus norvegicus
<308> AA892500
<400> 5798

accctaaaa  cactgtcag  tttatttaa  cttgatata  atttgtaca  gcaatttaa  60
aagactatt  cacaacgac  cagtgggtt  tacctggtt  gaagataat  cagttacaa  120
tgagaggta  aaacaccgt  gtaaagacc  aaaaataca  acatcctat  cataaacgt  180
caaattaac  gctagaatt  catacagat  aataatgta  aaattacat  actttgttc  240
ccaagtaaa  gaaaaccat  ttctctgtt  actttaatc  gcacactaa  gtaagtgtg  300
tgccaaaga  cttctgtgc  gctatcaga  cgcaggtca  tatgtcaaa  ttttgaagt  360
aaaagatta  aaccggtga  tggtttatt  aagtattaa  gcaggtaag  aaaagaaac  420
aaataatat  caacataga  accattctt  gggagatgt  gatctgcca  gaccagcta  480
ttgtgaact  agggttaac  ctgagaagt  cacattagt  tggagagag  tgcccattt  540
tctaaggga  aacaaacct  atttcttac  attttatgt  gaaactccac  590



<210> 5799
<211> 1037
<212> PRT
<213> Rattus norvegicus
<308> BAA77341
<400> 5799

Met Glu Val Val Gly Asp Phe Glu Tyr Cys Lys Arg Asp Leu Val Gly 
  1               5                  10                  15
His Gly Ala Phe Ala Val Val Phe Arg Gly Arg His Arg Gln Lys Thr 
             20                  25                  30
Asp Trp Glu Val Ala Ile Lys Ser Ile Asn Lys Lys Asn Leu Ser Lys 
         35                  40                  45
Ser Gln Ile Leu Leu Gly Lys Glu Ile Lys Ile Leu Lys Glu Leu Gln 
     50                  55                  60
His Glu Asn Ile Val Ala Leu Tyr Asp Val Gln Glu Leu Pro Asn Ser 
 65                  70                  75                  80
Val Phe Leu Val Met Glu Tyr Cys Asn Gly Gly Asp Leu Ala Asp Tyr 
                 85                  90                  95
Leu Gln Ala Lys Gly Thr Leu Ser Glu Asp Thr Ile Arg Val Phe Leu 
             100                105                110
His Gln Ile Ala Ala Ala Met Arg Ile Leu His Ser Lys Gly Ile Ile 
         115                120                125
His Arg Asp Leu Lys Pro Gln Asn Ile Leu Leu Ser Tyr Ala Asn Arg 
     130                135                140
Arg Lys Ser Asn Val Ser Gly Ile Arg Ile Lys Ile Ala Asp Phe Gly 
 145                150                155                160
Phe Ala Arg Tyr Leu His Ser Asn Thr Met Ala Ala Thr Leu Cys Gly 
                 165                170                175
Ser Pro Met Tyr Met Ala Pro Glu Val Ile Met Ser Gln His Tyr Asp 
             180                185                190
Ala Lys Ala Asp Leu Trp Ser Ile Gly Thr Val Ile Tyr Gln Cys Leu 
         195                200                205
Val Gly Lys Pro Pro Phe Gln Ala Asn Ser Pro Gln Asp Leu Arg Met 
     210                215                220
Phe Tyr Glu Lys Asn Arg Ser Leu Met Pro Ser Ile Pro Arg Glu Thr 
 225                230                235                240
Ser Pro Tyr Leu Ala Asn Leu Leu Leu Gly Leu Leu Gln Arg Asn Gln 
                 245                250                255
Lys Asp Arg Met Asp Phe Glu Ala Phe Phe Ser His Pro Phe Leu Glu 
             260                265                270
Gln Val Pro Val Lys Lys Ser Cys Pro Val Pro Val Pro Val Tyr Ser 
         275                280                285
Gly Pro Val Pro Gly Ser Ser Cys Ser Ser Ser Pro Ser Cys Arg Phe 
     290                295                300
Ala Ser Pro Pro Ser Leu Pro Asp Met Gln His Ile Gln Glu Glu Asn 
 305                310                315                320
Leu Ser Ser Pro Pro Leu Gly Pro Pro Asn Tyr Leu Gln Val Ser Lys 
                 325                330                335
Asp Ser Ala Ser Asn Ser Ser Lys Asn Ser Ser Cys Asp Thr Asp Asp 
             340                345                350
Phe Val Leu Val Pro His Asn Ile Ser Ser Asp His Ser Tyr Asp Met 
         355                360                365
Pro Met Gly Thr Thr Ala Arg Arg Ala Ser Asn Glu Phe Phe Met Cys 
     370                375                380
Gly Gly Gln Cys Gln Pro Thr Val Ser Pro His Ser Glu Thr Ala Pro 
 385                390                395                400
Ile Pro Val Pro Thr Gln Val Arg Asn Tyr Gln Arg Ile Glu Gln Asn 
                 405                410                415
Leu Ile Ser Thr Ala Ser Ser Gly Thr Asn Pro His Gly Ser Pro Arg 
             420                425                430
Ser Ala Val Val Arg Arg Ser Asn Thr Ser Pro Met Gly Phe Leu Arg 
         435                440                445
Val Gly Ser Cys Ser Pro Val Pro Gly Asp Thr Val Gln Thr Gly Gly 
     450                455                460
Arg Arg Leu Ser Thr Gly Ser Ser Arg Pro Tyr Ser Pro Ser Pro Leu 
 465                470                475                480
Val Gly Thr Ile Pro Glu Gln Phe Ser Gln Cys Cys Cys Gly His Pro 
                 485                490                495
Gln Gly His Glu Ala Arg Ser Arg His Ser Ser Gly Ser Pro Val Pro 
             500                505                510
Gln Thr Gln Ala Pro Gln Ser Leu Leu Leu Gly Ala Arg Leu Gln Ser 
         515                520                525
Ala Pro Thr Leu Thr Asp Ile Tyr Gln Asn Lys Gln Lys Leu Arg Lys 
     530                535                540
Gln His Ser Asp Pro Val Cys Pro Ser His Ala Gly Ala Gly Tyr Ser 
 545                550                555                560
Tyr Ser Pro Gln Pro Ser Arg Pro Gly Ser Leu Gly Thr Ser Pro Thr 
                 565                570                575
Lys His Thr Gly Ser Ser Pro Arg Asn Ser Asp Trp Phe Phe Lys Thr 
             580                585                590
Pro Leu Pro Thr Ile Ile Gly Ser Pro Thr Lys Thr Thr Ala Pro Phe 
         595                600                605
Lys Ile Pro Lys Thr Gln Ala Ser Ser Asn Leu Leu Ala Leu Val Thr 
     610                615                620
Arg His Gly Pro Ala Glu Ser Gln Ser Lys Asp Gly Asn Asp Pro Arg 
 625                630                635                640
Glu Cys Ser His Cys Leu Ser Val Gln Gly Ser Glu Arg His Arg Ser 
                 645                650                655
Glu Gln Gln Gln Ser Lys Ala Val Phe Gly Arg Ser Val Ser Thr Gly 
             660                665                670
Lys Leu Ser Glu Gln Gln Val Lys Ala Pro Leu Gly Gly His Gln Gly 
         675                680                685
Ser Thr Asp Ser Leu Asn Thr Glu Arg Pro Met Asp Val Ala Pro Ala 
     690                695                700
Gly Ala Cys Gly Val Met Leu Ala Leu Pro Ala Gly Thr Ala Ala Ser 
 705                710                715                720
Ala Arg Ala Val Leu Phe Thr Val Gly Ser Pro Pro His Ser Ala Thr 
                 725                730                735
Ala Pro Thr Cys Thr His Met Val Leu Arg Thr Arg Thr Thr Ser Val 
             740                745                750
Gly Ser Ser Ser Ser Gly Gly Ser Leu Cys Ser Ala Ser Gly Arg Val 
         755                760                765
Cys Val Gly Ser Pro Pro Gly Pro Gly Leu Gly Ser Ser Pro Pro Gly 
     770                775                780
Ala Glu Gly Ala Pro Ser Leu Arg Tyr Val Pro Tyr Gly Ala Ser Pro 
 785                790                795                800
Pro Ser Leu Glu Gly Leu Ile Thr Phe Glu Ala Pro Glu Leu Pro Glu 
                 805                810                815
Glu Thr Leu Met Glu Arg Glu His Thr Asp Thr Leu Arg His Leu Asn 
             820                825                830
Met Met Leu Met Phe Thr Glu Cys Val Leu Asp Leu Thr Ala Val Arg 
         835                840                845
Gly Gly Asn Pro Glu Leu Cys Thr Ser Ala Val Ser Leu Tyr Gln Ile 
     850                855                860
Gln Glu Ser Val Val Val Asp Gln Ile Ser Gln Leu Ser Lys Asp Trp 
 865                870                875                880
Gly Arg Val Glu Gln Leu Val Leu Tyr Met Lys Ala Ala Gln Leu Leu 
                 885                890                895
Ala Ala Ser Leu His Leu Ala Lys Ala Gln Val Lys Ser Gly Lys Leu 
             900                905                910
Ser Pro Ser Met Ala Val Lys Gln Val Val Lys Asn Leu Asn Glu Arg 
         915                920                925
Tyr Lys Phe Cys Ile Thr Met Cys Lys Lys Leu Thr Glu Lys Leu Asn 
     930                935                940
Arg Phe Phe Ser Asp Lys Gln Arg Phe Ile Asp Glu Ile Asn Ser Val 
 945                950                955                960
Thr Ala Glu Lys Leu Ile Tyr Asn Cys Ala Val Glu Met Val Gln Ser 
                 965                970                975
Ala Ala Leu Asp Glu Met Phe Gln Gln Thr Glu Asp Ile Val Tyr Arg 
             980                985                990
Tyr His Lys Ala Ala Val Leu Leu Glu Gly Leu Ser Lys Ile Leu Gln 
         995                1000                1005
Asp Pro Thr Asp Val Glu Asn Val His Lys Tyr Lys Cys Ser Ile Glu 
     1010                1015                1020
Arg Arg Leu Ser Ala Leu Cys Cys Ser Thr Ala Thr Val 
 1025                1030                1035



<210> 5800
<211> 5808
<212> DNA
<213> Homo sapiens
<308> AB014523
<400> 5800

gcgcgcgcg  gggcgttgg  cgccgccgc  aggcgggga  gcgcggggc  gcggcggtg  60
gggttctag  gcggcggcc  tcgccgtcg  agcagcgcc  cgagcgggg  gggccgagg  120
ggcccgacg  gctggggat  gagagtacc  ggcccctca  tgcctcaga  cgcgtgtgc  180
gctctgggc  cgcacagtg  cggtgacgg  acccctggc  cggcagcgc  gaggccgct  240
cgccagaca  ccagcggcc  gcggcaggc  gggccatga  cggcagggg  cgggccggg  300
ctcgctgac  ctggctccg  gcggcagct  ccccagttt  cgctccggt  tctcggcat  360
agagtccgc  cgggcccgg  gctgcggct  ccccagacc  gccgcacgc  ggcgcgctc  420
gggcccgcg  agccgcggt  ctgatacct  cgccgcact  cgccgcccg  ccgtccgct  480
tgtgccccg  gggcgcggc  atggaggtg  tgggtgact  cgagtacag  aagagggat  540
tcgtgggac  cggggcctt  gccgtggtc  tccgggggc  gcaccgcca  aaaactgat  600
gggaggtag  tattaaaag  attaataaa  agaacttgt  aaaatcaca  atactgctt  660
gaaaggaaa  taaaatctt  aaggaactt  agcatgaaa  tattgtagc  ctctatgat  720
ttcaggaat  acccaactc  gtctttttg  tgatggagt  ttgcaatgg  ggagacctc  780
cagattatt  gcaagcgaa  gggactctc  gtgaagaca  gatcagagt  tttctgcat  840
agattgctg  tgccatgcg  atcctgcac  gcaaaggaa  catccacag  gatctcaaa  900
cacagaaca  cttgctgtc  tatgccaat  gcagaaaat  aagtgtcag  ggtattcgc  960
tcaaaatag  ggattttgg  tttgctcgt  acctacata  taacatgat  gctgcaaca  1020
tgtgtggat  cccgatgta  atggctcct  aggttatta  gtctcaaca  tatgatgct  1080
aggctgact  gtggagcat  ggaacagtg  tataccaat  cctagttgg  aaaccacct  1140
ttcaggcca  tagtcctca  gacttaagg  tgttttatg  aaaaaacag  agcttaatg  1200
ctagtattc  cagagaaac  tcaccttat  tggctaatc  ccttttggg  ttgcttcag  1260
gaaaccaaa  agatagaat  gactttgaa  cgtttttta  ccatccttt  cttgagcaa  1320
gtccagtaa  aaaatcttg  ccagttcca  tgcccatgt  ttctggttc  gtctctgga  1380
gctcctgtg  cagctctcc  tcttgtcgt  ttgcttctc  accatccct  ccagatatg  1440
agcatattc  ggaagaaaa  ttatcttcc  caccattgg  tcctcccaa  tatctacaa  1500
tttccaaag  ttctgccag  actagtagc  agaactctt  ttgtgacac  gatgacttt  1560
ttttggtgc  acacaacat  tcgtcagac  actcatgtg  tatgccaat  gggactgct  1620
gcagacgtg  ttcaaatga  ttcttggtg  gtggagggc  gtgtcagcc  actgtgtca  1680
ctcacagcg  aacagcacc  attccagtt  ctactcaaa  aaggaatta  cagcgcata  1740
agcagaatc  tacatctac  gccagctca  gcacaaatg  acatggttc  ccaagatct  1800
cagtggtac  aaggtccaa  accagcccc  tgggcttcc  ccggccggg  tcatgctcc  1860
cagtaccag  agacacagc  cagacagtt  gacgaaggc  ctccactgg  tcttctagg  1920
cttactcac  ttccccttt  gttggtacc  ttcctgagc  attcagtca  tgctgctgt  1980
ggcatcctc  gggccatga  tccaggagt  gaaactcct  aggttctcc  gtgccacaa  2040
ctcagtccc  acagtctct  ttatcgggt  ctagactgc  gagcgcccc  accctcact  2100
acatctatc  gaacaagca  aagctcaga  aacagcact  tgaccccgt  tgcccatcc  2160
atactgggg  tgggtacag  tactcgcct  agcccagtc  gcctggcag  cttggaact  2220
ctcccacca  gcacttggg  tcctctcca  ggagttctg  ctggttctt  aaaactcct  2280
tgccaacaa  cattggctc  cctactaag  ccacagctc  tttcaaaat  cctaaaact  2340
aagcatctt  caacctgtt  gccttggtt  ctcgtcatg  gcctgctga  gaacagtcg  2400
aagatggga  tgagccacg  gaatgtgcc  attgcctct  agtgcaagg  agtgagagg  2460
agcgggccg  gcagcagag  aaggcagtg  ttggcagat  tgtcagtac  gggaagtta  2520
cagatcaac  aggaaagac  cctatatgt  gacatcagg  cagcacaga  agtttaaat  2580
cagaacgac  aatggatat  gctccggca  gagcctgtg  tggtgttct  gcacctcct  2640
caggtacag  agcaagttc  aaggctgtc  tcttcactg  agggtctcc  ccacacagt  2700
cggcagccc  cacttgtac  cacatgttc  ttcgaacaa  aacaacctc  gtggggccc  2760
gcaactccg  gggctctct  tgtgccatg  gtggccgcg  gtgcgtggg  tccccgcct  2820
gcccaggct  cggctcttc  cctccagga  cagaggcag  tcccagcct  agatacgtg  2880
cttacggtg  ttcaccccc  agcctagag  ggctcatca  ctttgaagc  cctgaactg  2940
cggaggaga  gctgatgga  cgggaacac  cagacacct  acgccatct  aatgtgatg  3000
tgatgttca  tgagtgtgt  ctggacctg  cagccatga  gggaggaaa  cctgagctg  3060
gcacatctg  tgtgtcctt  taccagatc  aggagagtg  ggtggtgga  cagatcagt  3120
agctgagca  agactgggg  cgggtggag  agctggtgt  gtacatgaa  gcagcacag  3180
tgcttgcgg  ttctctgca  cttgccaaa  cccagatca  gtccgggaa  ctgagccca  3240
ccacagctg  gaaacaagt  gtcaagaat  tgaacgaac  atataaatt  tgcatcacc  3300
tgcgcaaga  acttacaga  aagctgaat  gattcttct  tgacaaaca  aggtttatt  3360
atgaaatca  cagtgtgac  gcagagaaa  tcatctata  ttgtgctgt  gaaatggtt  3420
agtctgcag  cctggatga  atgtttcag  agaccgaag  tattgttta  cgctatcat  3480
aggcagccc  tcttttgga  ggcctaagt  ggattctac  ggaccctgc  gatattgaa  3540
atgtgcata  atataaatg  agtattgag  gaagactgt  ggcgctctg  catagcacc  3600
caaccgtgt  agcagcagg  tcatcccgt  gaccggtgg  gggaacgtg  ggtgatgcc  3660
ttgggatta  agcttgagt  ctgtcaccc  atccccagg  aactgtagc  tcttaactg  3720
tgactacca  agaacaagc  gtgatttga  aaaggaaaa  caatccaaa  actacatat  3780
tgtaggaaa  ctgccttat  ggagaaaat  accctttcc  tttttcttt  tagaagcag  3840
agcaagagt  tttggctcc  agtttggac  tggtgaata  atgtacctt  gaactagga  3900
aatcggtac  gttattctt  aagataatt  aaaatgaaa  aaagtgagt  ctcgtcact  3960
ggttcatca  agcagtgtg  gaaattcca  gtgtttgct  aggtgtaaa  gtaaatgta  4020
tcacccctc  tccaggcag  ttgatattt  gagtaagtt  gtttaaatc  gagcatgca  4080
ctttaaaca  ctcaggaag  aatagctta  gaagaagtg  aacatggat  ttggaagaa  4140
ttttgaaat  ttcaatttg  tcctaatat  gatacatgt  aatcttcca  aatctttca  4200
attgcacta  tttattaaa  caactgtgt  ttggatttt  taatttaac  aaggcacaa  4260
ggacttgtt  aaaatattt  acttgattg  atacataga  cctttccag  attcacatg  4320
aatctccag  gaactttta  gtggttaaa  cttgtattc  tgtgaacct  tgcacattt  4380
ttttttttt  cttctttat  tacacctac  gattttctc  gtaatgttt  tgttagctt  4440
tggttccat  ttttattgt  catgcagaa  gtacattga  gcctgtgac  ttaggttta  4500
taaaggcta  gtttatttg  gcagtatta  aaacaaaat  atggatcaa  agatactct  4560
gataatttg  atagggcca  aacaaagtt  gtgacctaa  ggcttgtta  tgatgtgga  4620
ttcctacat  cagtgagtg  aaaatgaag  tcgttttct  ttaggaaaa  gggcagctg  4680
cttctgcct  atgtgtatt  ttcatgtta  ttctgacag  tcaccaaat  gctagtcat  4740
gagaatgca  gcagttaac  taatatccc  ccaggaatg  ttcctacgt  gtgtattat  4800
tggtttctt  tacttacct  cttgaatac  tgaataaac  attcaccaa  tttaatcct  4860
ttattttaa  ccttttaca  aaaataatc  gaactcttt  acaaattgc  cagagctct  4920
tggcattaa  ctaatttta  tgtactgat  aaaacaaac  tggttgtcc  ttactttga  4980
aaagtaatg  aatttttac  ttatttatc  gtatgaaat  ccagtagtt  atttgaaca  5040
ttatttata  gacgtttgt  tttttaggt  tttaataca  tgtttctac  tctcatttg  5100
aactgcatg  attattctt  aaactaggt  aaactcact  aattgttgt  taatagcct  5160
tttattatt  cctgtacaa  tgtatatta  ggtaaaata  aactgacaa  gtgtttcta  5220
ggtgtagct  ggtacatat  aagtggctt  ttgagccag  tacttcctt  gtgagttta  5280
agacttggc  atgaatatc  tttgtcctg  cccaggatt  agatcttgg  tactgtcat  5340
caggcttcc  ggaacatag  ctgttttac  tccacaacc  tatttgtta  tagtgatac  5400
ttattttat  taatatttt  tattcacag  gaaatttca  tcatgttct  tcagttatc  5460
cctgtgtta  ctcagttgt  ggtttattc  atcctctcc  cttcctctc  catttcttt  5520
ttaacacag  atgaaacag  ttcagagag  ggaagtgat  ggcctaaag  caggaacta  5580
gcaagtggt  aagccatgc  ttgtgactt  caagttaat  cttcttgtt  ttgtatatt  5640
aaggtcttg  ggtagatgg  gtgtgtgaa  cagtgaagt  tcaacagca  aaaagaaca  5700
aatgtaaat  catgaataa  ggttctggt  atacttcca  tatcaaggc  aattaagag  5760
ttttgcctt  agtatagca  taataaaca  atgctttat  tttccctg  5808



<210> 5801
<211> 1036
<212> PRT
<213> Homo sapiens
<308> XP_008514
<400> 5801

Met Glu Val Val Gly Asp Phe Glu Tyr Ser Lys Arg Asp Leu Val Gly 
  1               5                  10                  15
His Gly Ala Phe Ala Val Val Phe Arg Gly Arg His Arg Gln Lys Thr 
             20                  25                  30
Asp Trp Glu Val Ala Ile Lys Ser Ile Asn Lys Lys Asn Leu Ser Lys 
         35                  40                  45
Ser Gln Ile Leu Leu Gly Lys Glu Ile Lys Ile Leu Lys Glu Leu Gln 
     50                  55                  60
His Glu Asn Ile Val Ala Leu Tyr Asp Val Gln Glu Leu Pro Asn Ser 
 65                  70                  75                  80
Val Phe Leu Val Met Glu Tyr Cys Asn Gly Gly Asp Leu Ala Asp Tyr 
                 85                  90                  95
Leu Gln Ala Lys Gly Thr Leu Ser Glu Asp Thr Ile Arg Val Phe Leu 
             100                105                110
His Gln Ile Ala Ala Ala Met Arg Ile Leu His Ser Lys Gly Ile Ile 
         115                120                125
His Arg Asp Leu Lys Pro Gln Asn Ile Leu Leu Ser Tyr Ala Asn Arg 
     130                135                140
Arg Lys Ser Ser Val Ser Gly Ile Arg Ile Lys Ile Ala Asp Phe Gly 
 145                150                155                160
Phe Ala Arg Tyr Leu His Ser Asn Met Met Ala Ala Thr Leu Cys Gly 
                 165                170                175
Ser Pro Met Tyr Met Ala Pro Glu Val Ile Met Ser Gln His Tyr Asp 
             180                185                190
Ala Lys Ala Asp Leu Trp Ser Ile Gly Thr Val Ile Tyr Gln Cys Leu 
         195                200                205
Val Gly Lys Pro Pro Phe Gln Ala Asn Ser Pro Gln Asp Leu Arg Met 
     210                215                220
Phe Tyr Glu Lys Asn Arg Ser Leu Met Pro Ser Ile Pro Arg Glu Thr 
 225                230                235                240
Ser Pro Tyr Leu Ala Asn Leu Leu Leu Gly Leu Leu Gln Arg Asn Gln 
                 245                250                255
Lys Asp Arg Met Asp Phe Glu Ala Phe Phe Ser His Pro Phe Leu Glu 
             260                265                270
Gln Gly Pro Val Lys Lys Ser Cys Pro Val Pro Val Pro Met Tyr Ser 
         275                280                285
Gly Ser Val Ser Gly Ser Ser Cys Gly Ser Ser Pro Ser Cys Arg Phe 
     290                295                300
Ala Ser Pro Pro Ser Leu Pro Asp Met Gln His Ile Gln Glu Glu Asn 
 305                310                315                320
Leu Ser Ser Pro Pro Leu Gly Pro Pro Asn Tyr Leu Gln Val Ser Lys 
                 325                330                335
Asp Ser Ala Ser Thr Ser Ser Lys Asn Ser Ser Cys Asp Thr Asp Asp 
             340                345                350
Phe Val Leu Val Pro His Asn Ile Ser Ser Asp His Ser Cys Asp Met 
         355                360                365
Pro Val Gly Thr Ala Gly Arg Arg Ala Ser Asn Glu Phe Leu Val Cys 
     370                375                380
Gly Gly Gln Cys Gln Pro Thr Val Ser Pro His Ser Glu Thr Ala Pro 
 385                390                395                400
Ile Pro Val Pro Thr Gln Ile Arg Asn Tyr Gln Arg Ile Glu Gln Asn 
                 405                410                415
Leu Thr Ser Thr Ala Ser Ser Gly Thr Asn Val His Gly Ser Pro Arg 
             420                425                430
Ser Ala Val Val Arg Arg Ser Asn Thr Ser Pro Met Gly Phe Leu Arg 
         435                440                445
Pro Gly Ser Cys Ser Pro Val Pro Ala Asp Thr Ala Gln Thr Val Gly 
     450                455                460
Arg Arg Leu Ser Thr Gly Ser Ser Arg Pro Tyr Ser Pro Ser Pro Leu 
 465                470                475                480
Val Gly Thr Ile Pro Glu Gln Phe Ser Gln Cys Cys Cys Gly His Pro 
                 485                490                495
Gln Gly His Asp Ser Arg Ser Arg Asn Ser Ser Gly Ser Pro Val Pro 
             500                505                510
Gln Ala Gln Ser Pro Gln Ser Leu Leu Ser Gly Ala Arg Leu Gln Ser 
         515                520                525
Ala Pro Thr Leu Thr Asp Ile Tyr Gln Asn Lys Gln Lys Leu Arg Lys 
     530                535                540
Gln His Ser Asp Pro Val Cys Pro Ser His Thr Gly Ala Gly Tyr Ser 
 545                550                555                560
Tyr Ser Pro Gln Pro Ser Arg Pro Gly Ser Leu Gly Thr Ser Pro Thr 
                 565                570                575
Lys His Leu Gly Ser Ser Pro Arg Ser Ser Asp Trp Phe Phe Lys Thr 
             580                585                590
Pro Leu Pro Thr Ile Ile Gly Ser Pro Thr Lys Thr Thr Ala Pro Phe 
         595                600                605
Lys Ile Pro Lys Thr Gln Ala Ser Ser Asn Leu Leu Ala Leu Val Thr 
     610                615                620
Arg His Gly Pro Ala Glu Glu Gln Ser Lys Asp Gly Asn Glu Pro Arg 
 625                630                635                640
Glu Cys Ala His Cys Leu Leu Val Gln Gly Ser Glu Arg Gln Arg Ala 
                 645                650                655
Glu Gln Gln Ser Lys Ala Val Phe Gly Arg Ser Val Ser Thr Gly Lys 
             660                665                670
Leu Ser Asp Gln Gln Gly Lys Thr Pro Ile Cys Arg His Gln Gly Ser 
         675                680                685
Thr Asp Ser Leu Asn Thr Glu Arg Pro Met Asp Ile Ala Pro Ala Gly 
     690                695                700
Ala Cys Gly Gly Val Leu Ala Pro Pro Ala Gly Thr Ala Ala Ser Ser 
 705                710                715                720
Lys Ala Val Leu Phe Thr Val Gly Ser Pro Pro His Ser Ala Ala Ala 
                 725                730                735
Pro Thr Cys Thr His Met Phe Leu Arg Thr Arg Thr Thr Ser Val Gly 
             740                745                750
Pro Ser Asn Ser Gly Gly Ser Leu Cys Ala Met Ser Gly Arg Val Cys 
         755                760                765
Val Gly Ser Pro Pro Gly Pro Gly Phe Gly Ser Ser Pro Pro Gly Ala 
     770                775                780
Glu Ala Ala Pro Ser Leu Arg Tyr Val Pro Tyr Gly Ala Ser Pro Pro 
 785                790                795                800
Ser Leu Glu Gly Leu Ile Thr Phe Glu Ala Pro Glu Leu Pro Glu Glu 
                 805                810                815
Thr Leu Met Glu Arg Glu His Thr Asp Thr Leu Arg His Leu Asn Val 
             820                825                830
Met Leu Met Phe Thr Glu Cys Val Leu Asp Leu Thr Ala Met Arg Gly 
         835                840                845
Gly Asn Pro Glu Leu Cys Thr Ser Ala Val Ser Leu Tyr Gln Ile Gln 
     850                855                860
Glu Ser Val Val Val Asp Gln Ile Ser Gln Leu Ser Lys Asp Trp Gly 
 865                870                875                880
Arg Val Glu Gln Leu Val Leu Tyr Met Lys Ala Ala Gln Leu Leu Ala 
                 885                890                895
Ala Ser Leu His Leu Ala Lys Ala Gln Ile Lys Ser Gly Lys Leu Ser 
             900                905                910
Pro Ser Thr Ala Val Lys Gln Val Val Lys Asn Leu Asn Glu Arg Tyr 
         915                920                925
Lys Phe Cys Ile Thr Met Cys Lys Lys Leu Thr Glu Lys Leu Asn Arg 
     930                935                940
Phe Phe Ser Asp Lys Gln Arg Phe Ile Asp Glu Ile Asn Ser Val Thr 
 945                950                955                960
Ala Glu Lys Leu Ile Tyr Asn Cys Ala Val Glu Met Val Gln Ser Ala 
                 965                970                975
Ala Leu Asp Glu Met Phe Gln Gln Thr Glu Asp Ile Val Tyr Arg Tyr 
             980                985                990
His Lys Ala Ala Leu Leu Leu Glu Gly Leu Ser Arg Ile Leu Gln Asp 
         995                1000                1005
Pro Ala Asp Ile Glu Asn Val His Lys Tyr Lys Cys Ser Ile Glu Arg 
     1010                1015                1020
Arg Leu Ser Ala Leu Cys His Ser Thr Ala Thr Val 
 1025                1030                1035



<210> 5802
<211> 562
<212> DNA
<213> Rattus norvegicus
<308> AA892505
<400> 5802

cgagagcag  agaggattt  ttaggggct  agtcatcat  tggaagccc  agagcattg  60
gcagaggaa  ctgtggcgg  aacagggct  gtcatggta  ggccttgcc  gagcctgac  120
ctgattccg  gacctggtg  acccagtgc  gatacgggg  attcccctg  tccacgggc  180
gtgcgatca  ctcggcaac  tcataaggg  gcacagatc  gacaaactc  gtcagagca  240
ggaccaggg  gctttgtgt  ttaatcatc  tcagcacct  actatcttc  tcgatcttt  300
ctttccatt  atagatgga  gtgatctgc  ggatgaggt  gacgcaggc  gccaggcgc  360
tctctacca  tgccctggc  atctccttg  cgacttttt  gttcggaca  gtgacaaag  420
ctgcagaga  tgatcctgg  acgtagccg  agcccgagg  cggcgacgg  tgggacgga  480
ggcttccag  agccatgga  agcagagct  ggggtagca  taaaaggcg  gaagccacc  540
gcagtaagg  aggcatgca  ag  562



<210> 5803
<211> 134
<212> PRT
<213> Rattus norvegicus
<308> BAB23217
<400> 5803

Met Ala Ser Gly Ser Pro Pro Ser Gln Pro Pro Pro Ala Ser Gly Ser 
  1               5                  10                  15
Gly Tyr Val Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn 
             20                  25                  30
Glu Lys Val Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu 
         35                  40                  45
Ala Ala Cys Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp 
     50                  55                  60
Lys Gly Lys Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr 
 65                  70                  75                  80
Gln Ser Ser Leu Val Pro Ala Leu Thr Glu Phe Val Arg Ser Val His 
                 85                  90                  95
Pro Tyr Glu Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn 
             100                105                110
Pro Pro Tyr Leu His Trp Val His Gln Val Thr Glu Ser Val Ser Asn 
         115                120                125
Ser Gly Thr Ala Leu Pro 
     130



<210> 5804
<211> 624
<212> DNA
<213> Homo sapiens
<308> AF230924
<400> 5804

cgcctcctg  tctcaggcc  ctctgctcc  gtcttttgt  tggatgccg  cgctgctgc  60
tgtggcctc  cgccttttg  tgctacccc  agtcttgct  accatggcc  ctggaagcc  120
tccgaccca  ccctcgccg  cctcggatt  cggctctgg  tacgttccg  gctcggtct  180
tgcagcctt  gttacttgc  ccaacgaga  ggtcgccaa  gagatcgcc  gggccgtgg  240
ggagaagcg  ctagcagcc  gcgtcaacc  catccctca  attacatcc  tctatgagt  300
gaaagggaa  atcgaggaa  acagtgagg  gctgatgat  attaaaacc  aaagttcct  360
ggtcccagc  ttgacagat  ttgttcgtt  tgtgcaccc  tacgaagtg  ccgaggtaa  420
tgcattgcc  gtggaacag  ggaactttc  gtacctgca  tgggtgcgc  aggtcacag  480
gtcagtttc  gactctatc  cagtcctgc  atgatgagc  ctgttcctg  tcatcatga  540
gatccccgc  atacttcaa  gccttctga  ttccaggtg  tgactgggc  cccaataaa  600
cccgtcttt  ggtcaaaaa  aaaa  624



<210> 5805
<211> 137
<212> PRT
<213> Homo sapiens
<308> AF230924
<400> 5805

Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser 
  1               5                  10                  15
Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys 
             20                  25                  30
Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys 
         35                  40                  45
Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr 
     50                  55                  60
Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile 
 65                  70                  75                  80
Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser 
                 85                  90                  95
Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln 
             100                105                110
Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val 
         115                120                125
Ser Asp Ser Ile Thr Val Leu Pro Ter 
     130                135



<210> 5806
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AA892507
<400> 5806

cacagtaac  catgaggtg  ataacagag  gagggagct  ccctggatg  cctgcagcc  60
tccctccaa  ggaaccttc  gacaccact  caaagaatc  aggaaaggt  cctgtggtg  120
gtctgctct  tgctgagct  cactgacac  ctggccttt  tcagcaggg  ggggtgact  180
cagtccata  tcatcctcc  gcttgtctt  atggtcgag  ttattcttt  ctgtcgtag  240
ctttctcgg  tcatcttct  aatcctgag  ctctgaagc  gagcatctt  tttggatgg  300
tccttgggc  cctggctgg  cttggcaat  atgtctcga  ttttctgta  gcattctgc  360
agattgcgg  actggtatc  gctgctctc  gaggtaagt  ccagctctc  tgccttgtt  420
atcgtgagg  caatcttct  gcgtacagg  tccgcaatc  agtctgcac  ggccaagtg  480
aaccttact  cggccttgg  attcacttt  ttaacgttc  gccctccag  accgctgct  540
c  541



<210> 5807
<211> 170
<212> PRT
<213> Rattus norvegicus
<308> BAB22691
<400> 5807

Thr Thr Phe Gln Ser Ile Tyr Ser Leu Asp Lys Leu Tyr Pro Glu Ser 
  1               5                  10                  15
Lys Gly Ala Asp Thr Ala Trp Lys Val Pro Glu His Ala Lys Gln Ala 
             20                  25                  30
Ser Ser Tyr Ile Pro Leu Asp Arg Leu Ser Ile Ser Tyr Cys Arg Ser 
         35                  40                  45
Ser Gly Pro Gly Gly Gln Asn Val Asn Lys Val Asn Ser Lys Ala Glu 
     50                  55                  60
Val Arg Phe His Leu Ala Ser Ala Asp Trp Ile Glu Glu Pro Val Arg 
 65                  70                  75                  80
Gln Lys Ile Ala Leu Thr His Lys Asn Lys Ile Asn Lys Ala Gly Glu 
                 85                  90                  95
Leu Val Leu Thr Ser Glu Ser Ser Arg Tyr Gln Phe Arg Asn Leu Ala 
             100                105                110
Glu Cys Leu Gln Lys Ile Arg Asp Met Ile Ala Glu Ala Ser Gln Val 
         115                120                125
Pro Lys Glu Pro Ser Lys Glu Asp Ala Arg Leu Gln Arg Leu Arg Ile 
     130                135                140
Glu Lys Met Asn Arg Glu Arg Leu Arg Gln Lys Arg Leu Asn Ser Ala 
 145                150                155                160
Leu Lys Thr Ser Arg Arg Met Thr Met Asp 
                 165                170



<210> 5808
<211> 888
<212> DNA
<213> Homo sapiens
<308> NM_001545
<400> 5808

gcatggcgg  caccaggtg  ctgcgctgg  gcctgagcc  agccggagt  tggctgctc  60
caccgcccg  acggtgccc  cgccgggcg  tgcacaagc  gaaagacgg  actgagttc  120
agagcatct  cagcctgga  aagctctac  ccgaatctc  gggctcgga  accgcctgg  180
gggtcccga  tggtgcaaa  caagccgac  gtgacatcc  tctagatcg  ttgacaata  240
cttattgtc  gagtagtgg  cctgggggg  agaatgtga  caaagtgaa  tccaaggca  300
aagtcaggt  ccatttggc  actgccgag  ggatcgcgg  gcccgtgcg  cagaagata  360
ccatcacgc  taaaaacaa  atcaacagg  taggagagt  gatccttac  tctgagagc  420
gccgctatc  gttccggaa  ctggcagat  gcctgcaga  aattcgaga  atgatcact  480
aggccagcc  gacaccgaa  gagccaaca  aagaagatg  taaacttca  agaatcagg  540
tagaaaaca  gaatcggga  aggctgaga  aaaagagaa  tcattctgc  gtaaagaca  600
gcaggaggg  cgacatgga  tgaaatcac  ctctgcagc  gggagggct  ttctgggcg  660
ccgggcagc  gcagctgag  ggactttca  accataagg  gatttctgt  tttcttttt  720
gctgttaat  cttgtctat  acattggag  catcacaag  atgttcatt  ggaatgaag  780
ctgcaggca  tggttgcag  cgtctttat  ggcagtcac  atgttgtca  accttaata  840
tgcacctca  gtattagtc  caataaaaa  cagaactca  aaaaaaaa  888



<210> 5809
<211> 206
<212> PRT
<213> Homo sapiens
<308> Q14197
<400> 5809

Met Ala Ala Thr Arg Cys Leu Arg Trp Gly Leu Ser Arg Ala Gly Val 
  1               5                  10                  15
Trp Leu Leu Pro Pro Pro Ala Arg Cys Pro Arg Arg Ala Leu His Lys 
             20                  25                  30
Gln Lys Asp Gly Thr Glu Phe Lys Ser Ile Tyr Ser Leu Asp Lys Leu 
         35                  40                  45
Tyr Pro Glu Ser Gln Gly Ser Asp Thr Ala Trp Arg Val Pro Asn Gly 
     50                  55                  60
Ala Lys Gln Ala Asp Ser Asp Ile Pro Leu Asp Arg Leu Thr Ile Ser 
 65                  70                  75                  80
Tyr Cys Arg Ser Ser Gly Pro Gly Gly Gln Asn Val Asn Lys Val Asn 
                 85                  90                  95
Ser Lys Ala Glu Val Arg Phe His Leu Ala Thr Ala Glu Trp Ile Ala 
             100                105                110
Glu Pro Val Arg Gln Lys Ile Ala Ile Thr His Lys Asn Lys Ile Asn 
         115                120                125
Arg Leu Gly Glu Leu Ile Leu Thr Ser Glu Ser Ser Arg Tyr Gln Phe 
     130                135                140
Arg Asn Leu Ala Asp Cys Leu Gln Lys Ile Arg Asp Met Ile Thr Glu 
 145                150                155                160
Ala Ser Gln Thr Pro Lys Glu Pro Thr Lys Glu Asp Val Lys Leu His 
                 165                170                175
Arg Ile Arg Ile Glu Asn Met Asn Arg Glu Arg Leu Arg Gln Lys Arg 
             180                185                190
Ile His Ser Ala Val Lys Thr Ser Arg Arg Val Asp Met Asp 
         195                200                205



<210> 5810
<211> 593
<212> DNA
<213> Rattus norvegicus
<308> AA892511
<400> 5810

ccgggctca  taggaaacc  ttattgtca  cattagaga  aaaaacatc  gagtcccac  60
cgccacacc  cacaaggag  ctaactgaa  ggttactga  tgtcacagc  gcccagaca  120
agggctgaa  ctcggtcct  agccacccc  tcccctgca  gatcagtgg  agagggcaa  180
ggtctccat  ttgaggaag  ggatgtgca  cttggtctc  atgtcgatg  cctgccaga  240
cttcaggaa  tcctcaaag  tgatcccct  gtacacctg  tccggttcc  tctgtccca  300
gcacacgct  gcagcctcc  tcatggctc  gtcggcgat  gaccgagct  actccttct  360
gatgtgagg  tttccagag  gcagttcct  caccacatt  cgatactct  ccagggtga  420
gcggccgtc  ctgtccgag  catacatat  gaacagaaa  ttcagcttc  ccttccgag  480
cagctccac  tgttcctca  ccagggtag  gtcaatggg  cggaagtag  acatgatag  540
caggaagtc  tcgaagttg  tctcatcgg  caggccgct  gacccctta  gca  593



<210> 5811
<211> 214
<212> PRT
<213> Rattus norvegicus
<308> AAF40439
<400> 5811

Met Gly Ala Ala His Ser Ala Ser Glu Glu Val Arg Glu Leu Glu Gly 
  1               5                  10                  15
Lys Thr Gly Phe Ser Ser Asp Gln Ile Glu Gln Leu His Arg Arg Phe 
             20                  25                  30
Lys Gln Leu Ser Gly Asp Gln Pro Thr Ile Arg Lys Glu Asn Phe Asn 
         35                  40                  45
Asn Val Pro Asp Leu Glu Leu Asn Pro Ile Arg Ser Lys Ile Val Arg 
     50                  55                  60
Ala Phe Phe Asp Asn Arg Asn Leu Arg Lys Gly Ser Ser Gly Leu Ala 
 65                  70                  75                  80
Asp Glu Ile Asn Leu Glu Asp Phe Leu Thr Ile Met Ser Tyr Phe Arg 
                 85                  90                  95
Pro Ile Asp Thr Thr Leu Gly Glu Glu Gln Val Glu Leu Ser Arg Lys 
             100                105                110
Glu Lys Leu Lys Phe Leu Phe His Met Tyr Asp Ser Asp Ser Asp Gly 
         115                120                125
Arg Ile Thr Leu Glu Glu Tyr Arg Asn Val Val Glu Glu Leu Leu Ser 
     130                135                140
Gly Asn Pro His Ile Glu Lys Glu Ser Ala Arg Ser Ile Ala Asp Gly 
 145                150                155                160
Ala Met Met Glu Ala Ala Ser Val Cys Val Gly Gln Met Glu Pro Asp 
                 165                170                175
Gln Val Tyr Glu Gly Ile Thr Phe Glu Asp Phe Leu Lys Ile Trp Gln 
             180                185                190
Gly Ile Asp Ile Glu Thr Lys Met His Ile Arg Phe Leu Asn Met Glu 
         195                200                205
Thr Ile Ala Leu Cys His 
     210



<210> 5812
<211> 800
<212> DNA
<213> Homo sapiens
<308> U61538
<400> 5812

gaattccgg  caaagctct  tcaccagat  tagactgta  ccctgctgc  ttccctcca  60
cgagtctgc  agcatgctt  ttcatcctt  ttatatgtt  tttgcttcc  tccctccct  120
cttgcctcc  gtcgccgtc  cttctggcg  cgctgctcc  ggaggagct  ccggcacgg  180
gatgggttc  cgggcctcc  cgttactgc  ggacgaaga  ctcgaggag  tcaagaagg  240
gaccggctt  tcccacagt  aaatcactc  cctctacag  cggttcacc  gcctggaca  300
aggagagaa  gggactctc  gccgggaag  tttccagag  attccagaa  ttgccatca  360
cccactggg  gaccggatc  tcaatgcct  ctttccaga  ggagaggac  aggtaaact  420
ccgtggatt  atgcgaact  tggctcatt  ccgccccat  gaggataat  aaaagagca  480
agatgtgaa  ggacccgaa  cactcaaca  ccgaagcaa  aaactgcac  ttgcttttc  540
actatatga  ttggataaa  atgaaaaga  ctcccgtga  gagctgtta  aggtgctac  600
catgatggt  ggagtaaat  tctcagatg  gcagctggg  agcatcgca  acaggacca  660
tcaggaggc  gatcaggat  gggacagtg  catatcttt  acagaattt  ttaaggttt  720
ggagaaggt  gatgtagaa  agaaaatga  catccgatt  cttcactaa  ggagaccaa  780
ctgttcttg  ggtctagtat  800



<210> 5813
<211> 194
<212> PRT
<213> Homo sapiens
<308> Q99653
<400> 5813

Gly Ser Arg Ala Ser Thr Leu Leu Arg Asp Glu Glu Leu Glu Glu Ile 
  1               5                  10                  15
Lys Lys Glu Thr Gly Phe Ser His Ser Gln Ile Thr Arg Leu Tyr Ser 
             20                  25                  30
Arg Phe Thr Ser Leu Asp Lys Gly Glu Asn Gly Thr Leu Ser Arg Glu 
         35                  40                  45
Asp Phe Gln Arg Ile Pro Glu Leu Ala Ile Asn Pro Leu Gly Asp Arg 
     50                  55                  60
Ile Ile Asn Ala Phe Phe Pro Glu Gly Glu Asp Gln Val Asn Phe Arg 
 65                  70                  75                  80
Gly Phe Met Arg Thr Leu Ala His Phe Arg Pro Ile Glu Asp Asn Glu 
                 85                  90                  95
Lys Ser Lys Asp Val Asn Gly Pro Glu Pro Leu Asn Ser Arg Ser Asn 
             100                105                110
Lys Leu His Phe Ala Phe Arg Leu Tyr Asp Leu Asp Lys Asp Glu Lys 
         115                120                125
Ile Ser Arg Asp Glu Leu Leu Gln Val Leu Arg Met Met Val Gly Val 
     130                135                140
Asn Ile Ser Asp Glu Gln Leu Gly Ser Ile Ala Asp Arg Thr Ile Gln 
 145                150                155                160
Glu Ala Asp Gln Asp Gly Asp Ser Ala Ile Ser Phe Thr Glu Phe Val 
                 165                170                175
Lys Val Leu Glu Lys Val Asp Val Glu Gln Lys Met Ser Ile Arg Phe 
             180                185                190
Leu His 
         195



<210> 5814
<211> 593
<212> DNA
<213> Rattus norvegicus
<308> AA892511
<400> 5814

ccgggctca  taggaaacc  ttattgtca  cattagaga  aaaaacatc  gagtcccac  60
cgccacacc  cacaaggag  ctaactgaa  ggttactga  tgtcacagc  gcccagaca  120
agggctgaa  ctcggtcct  agccacccc  tcccctgca  gatcagtgg  agagggcaa  180
ggtctccat  ttgaggaag  ggatgtgca  cttggtctc  atgtcgatg  cctgccaga  240
cttcaggaa  tcctcaaag  tgatcccct  gtacacctg  tccggttcc  tctgtccca  300
gcacacgct  gcagcctcc  tcatggctc  gtcggcgat  gaccgagct  actccttct  360
gatgtgagg  tttccagag  gcagttcct  caccacatt  cgatactct  ccagggtga  420
gcggccgtc  ctgtccgag  catacatat  gaacagaaa  ttcagcttc  ccttccgag  480
cagctccac  tgttcctca  ccagggtag  gtcaatggg  cggaagtag  acatgatag  540
caggaagtc  tcgaagttg  tctcatcgg  caggccgct  gacccctta  gca  593



<210> 5815
<211> 214
<212> PRT
<213> Rattus norvegicus
<308> AAF40439
<400> 5815

Met Gly Ala Ala His Ser Ala Ser Glu Glu Val Arg Glu Leu Glu Gly 
  1               5                  10                  15
Lys Thr Gly Phe Ser Ser Asp Gln Ile Glu Gln Leu His Arg Arg Phe 
             20                  25                  30
Lys Gln Leu Ser Gly Asp Gln Pro Thr Ile Arg Lys Glu Asn Phe Asn 
         35                  40                  45
Asn Val Pro Asp Leu Glu Leu Asn Pro Ile Arg Ser Lys Ile Val Arg 
     50                  55                  60
Ala Phe Phe Asp Asn Arg Asn Leu Arg Lys Gly Ser Ser Gly Leu Ala 
 65                  70                  75                  80
Asp Glu Ile Asn Leu Glu Asp Phe Leu Thr Ile Met Ser Tyr Phe Arg 
                 85                  90                  95
Pro Ile Asp Thr Thr Leu Gly Glu Glu Gln Val Glu Leu Ser Arg Lys 
             100                105                110
Glu Lys Leu Lys Phe Leu Phe His Met Tyr Asp Ser Asp Ser Asp Gly 
         115                120                125
Arg Ile Thr Leu Glu Glu Tyr Arg Asn Val Val Glu Glu Leu Leu Ser 
     130                135                140
Gly Asn Pro His Ile Glu Lys Glu Ser Ala Arg Ser Ile Ala Asp Gly 
 145                150                155                160
Ala Met Met Glu Ala Ala Ser Val Cys Val Gly Gln Met Glu Pro Asp 
                 165                170                175
Gln Val Tyr Glu Gly Ile Thr Phe Glu Asp Phe Leu Lys Ile Trp Gln 
             180                185                190
Gly Ile Asp Ile Glu Thr Lys Met His Ile Arg Phe Leu Asn Met Glu 
         195                200                205
Thr Ile Ala Leu Cys His 
     210



<210> 5816
<211> 800
<212> DNA
<213> Homo sapiens
<308> U61538
<400> 5816

gaattccgg  caaagctct  tcaccagat  tagactgta  ccctgctgc  ttccctcca  60
cgagtctgc  agcatgctt  ttcatcctt  ttatatgtt  tttgcttcc  tccctccct  120
cttgcctcc  gtcgccgtc  cttctggcg  cgctgctcc  ggaggagct  ccggcacgg  180
gatgggttc  cgggcctcc  cgttactgc  ggacgaaga  ctcgaggag  tcaagaagg  240
gaccggctt  tcccacagt  aaatcactc  cctctacag  cggttcacc  gcctggaca  300
aggagagaa  gggactctc  gccgggaag  tttccagag  attccagaa  ttgccatca  360
cccactggg  gaccggatc  tcaatgcct  ctttccaga  ggagaggac  aggtaaact  420
ccgtggatt  atgcgaact  tggctcatt  ccgccccat  gaggataat  aaaagagca  480
agatgtgaa  ggacccgaa  cactcaaca  ccgaagcaa  aaactgcac  ttgcttttc  540
actatatga  ttggataaa  atgaaaaga  ctcccgtga  gagctgtta  aggtgctac  600
catgatggt  ggagtaaat  tctcagatg  gcagctggg  agcatcgca  acaggacca  660
tcaggaggc  gatcaggat  gggacagtg  catatcttt  acagaattt  ttaaggttt  720
ggagaaggt  gatgtagaa  agaaaatga  catccgatt  cttcactaa  ggagaccaa  780
ctgttcttg  ggtctagtat  800



<210> 5817
<211> 194
<212> PRT
<213> Homo sapiens
<308> Q99653
<400> 5817

Gly Ser Arg Ala Ser Thr Leu Leu Arg Asp Glu Glu Leu Glu Glu Ile 
  1               5                  10                  15
Lys Lys Glu Thr Gly Phe Ser His Ser Gln Ile Thr Arg Leu Tyr Ser 
             20                  25                  30
Arg Phe Thr Ser Leu Asp Lys Gly Glu Asn Gly Thr Leu Ser Arg Glu 
         35                  40                  45
Asp Phe Gln Arg Ile Pro Glu Leu Ala Ile Asn Pro Leu Gly Asp Arg 
     50                  55                  60
Ile Ile Asn Ala Phe Phe Pro Glu Gly Glu Asp Gln Val Asn Phe Arg 
 65                  70                  75                  80
Gly Phe Met Arg Thr Leu Ala His Phe Arg Pro Ile Glu Asp Asn Glu 
                 85                  90                  95
Lys Ser Lys Asp Val Asn Gly Pro Glu Pro Leu Asn Ser Arg Ser Asn 
             100                105                110
Lys Leu His Phe Ala Phe Arg Leu Tyr Asp Leu Asp Lys Asp Glu Lys 
         115                120                125
Ile Ser Arg Asp Glu Leu Leu Gln Val Leu Arg Met Met Val Gly Val 
     130                135                140
Asn Ile Ser Asp Glu Gln Leu Gly Ser Ile Ala Asp Arg Thr Ile Gln 
 145                150                155                160
Glu Ala Asp Gln Asp Gly Asp Ser Ala Ile Ser Phe Thr Glu Phe Val 
                 165                170                175
Lys Val Leu Glu Lys Val Asp Val Glu Gln Lys Met Ser Ile Arg Phe 
             180                185                190
Leu His 
         195



<210> 5818
<211> 560
<212> DNA
<213> Rattus norvegicus
<308> AA892522
<400> 5818

aaatgaaac  aggtttatg  cacacagtc  aacaatgta  aaagagctt  aagtagaaa  60
gcttgtgga  aatgtatac  ctttacatg  tacatacag  tttatagct  ataaataaa  120
acagagaac  ggagccatt  ttcacatta  cgaccagca  cacagagca  cagtaacaa  180
acaaacaca  tttccttcg  ctcagccac  aaaacttga  atggtctca  catacttga  240
gaaaatgac  ggtggtgaa  tgttacagc  acacccaca  caccaagtg  tttaagttg  300
ctctgggtt  gaaatatca  caaccgtat  aactccaga  agaagaagg  agggtaaga  360
cctgtccta  aaggcactt  ataaattga  actaccctt  tcttaaaat  ctgcaaatt  420
gccttgaaa  atgctgatg  tttacggcg  aatttaggt  tcttttatc  aggtttaga  480
atagacata  tttgaataa  ttgataata  tgtctgatg  ccactcttt  caccagctt  540
aaaatggac  catttaaact  560



<210> 5819
<211> 502
<212> DNA
<213> Rattus norvegicus
<308> AA892526
<400> 5819

cagactgca  aacccattt  atcggaatt  taaaagggg  tgtacatct  tgttccagc  60
ctttgaagc  ggtagatct  tgagttcaa  gccagcctg  tctacagag  gtgtgccag  120
acacccacg  ctatgtaga  ttaccctgc  ggggggcgg  ggggagcat  ccatagcct  180
gttccatgc  aactcgagt  tgtggaaag  cactctact  tcaggtcct  tggggatcg  240
aggtccaag  ctctaccca  agggtcatg  tgacttggg  tacagggtt  cttcctgta  300
cctcaatcc  caggagctg  aggtggtat  gtagcttcc  gggttctgc  aggcctgct  360
attccctcc  cctcgtaaa  agagtgaag  ttgttgatc  ggaagatct  gtcctcccc  420
tcattccgg  tctgttcct  gagcaggca  atgaccttc  tttgtcctt  caccacctg  480
atgttgagg  agacctcgt  cc  502



<210> 5820
<211> 1639
<212> DNA
<213> Homo sapiens
<308> AB002405
<400> 5820

ctccactgt  ggcgtgagc  tctttatca  ctgcatcac  ctggtgtac  gcatggctc  60
ctctttcgg  gagagctac  gggtgggca  cacctctgg  atccacgcc  tcaccgtct  120
ctgctcctg  gactacaag  tgacgcaga  gcgggcctc  cgcctccag  aggacaata  180
tcgcacccg  ctgaaggag  tgctggccg  gtggcagct  cggcacagc  ccaggagcg  240
gtgcgggag  ctgcggcag  cggctgtgc  ggggcttgt  tggctgctg  gtctgggga  300
cgcgctggg  tgcgccgtg  ccgtccacg  cttctcgga  ttcatgatc  agagtccag  360
ggctgctgg  caggaggct  tgctgctgg  cctgcccct  gtggttggc  tcctcaacc  420
gggggcccc  tacctgtgc  gtgtcctgg  cgccctgga  ccgcatgac  ccccggtac  480
ggaggtgta  gtggccatc  gcaggaacc  catcctcaa  ctggccatc  tggggacac  540
gtgctacca  tggctgggc  gcagggtgg  cgtcctgca  ggccagtgc  gggaggatt  600
tgtgggcca  gagctgtac  ggttcctgg  gatggactt  gtcctcatg  tgctggaca  660
gctttttgg  gaactggtg  ggaggatta  ctccgagaa  aagctgaag  ggaggcgga  720
gccggagtt  gacattgcc  ggaatgtcc  ggagctgat  tatgggcag  ctctgacct  780
gctgggggt  ctcttctcg  ccctcctcc  cgccgtgca  atcatcaag  tgctgctcg  840
cttctatgt  aagaagacc  gccttctgg  caactgcca  gcgccgcgc  ggccctggc  900
ggcctcaca  atgagcacc  tcttcctca  gctgctctg  ttccccgcc  tcctgggcg  960
cgctgtctt  ctctgctac  ccgtctggc  ggtgaagcc  tcgagcacc  gcggcccct  1020
ccggaccct  gacaccatg  acgaggccg  cagggtgtg  gtgcgccac  tggaggcgg  1080
aggccccag  gtctcctgg  tgccctggg  gcaccggta  ctgatggaa  acaccttct  1140
tgtcttcct  gtgtcagcc  tgctgctgg  cgtgatcta  ctcaacatc  aggtggtgc  1200
gggccagcg  aaggtcatc  gcctgctca  ggagcagat  agcaatgag  gtgaggaca  1260
aatcttctt  atcaacaag  ttcactcca  ctacgagag  aaggagagg  aggagagga  1320
cagggttgg  acaaccgag  aggctgcgg  accccctgc  ctgctcaca  atgaacagg  1380
tgcctaggg  gacggcgat  ggcctcacg  gcccgccca  caccctgag  ccacactgt  1440
gcctcccag  gaccctgct  ggacaccag  acaaggaag  cagtttcgc  tctcgaaag  1500
cgcagctgc  cctaggctg  agctggaag  gtgggtgaa  ccggcttgg  catccccaa  1560
gaactctgc  ctgcctggg  ctctattta  tctgattaa  ggggttttg  aaataaaaa  1620
aaaaaaaaa  aaaaaaaaa  1639



<210> 5821
<211> 445
<212> PRT
<213> Homo sapiens
<308> AB002405
<400> 5821

Met Ala His Ser Phe Gly Glu Ser Tyr Arg Val Gly Ser Thr Ser Gly 
  1               5                  10                  15
Ile His Ala Ile Thr Val Phe Cys Ser Trp Asp Tyr Lys Val Thr Gln 
             20                  25                  30
Lys Arg Ala Ser Arg Leu Gln Gln Asp Asn Ile Arg Thr Arg Leu Lys 
         35                  40                  45
Glu Leu Leu Ala Glu Trp Gln Leu Arg His Ser Pro Arg Ser Val Cys 
     50                  55                  60
Gly Arg Leu Arg Gln Ala Ala Val Leu Gly Leu Val Trp Leu Leu Cys 
 65                  70                  75                  80
Leu Gly Thr Ala Leu Gly Cys Ala Val Ala Val His Val Phe Ser Glu 
                 85                  90                  95
Phe Met Ile Gln Ser Pro Glu Ala Ala Gly Gln Glu Ala Val Leu Leu 
             100                105                110
Val Leu Pro Leu Val Val Gly Leu Leu Asn Leu Gly Ala Pro Tyr Leu 
         115                120                125
Cys Arg Val Leu Ala Ala Leu Glu Pro His Asp Ser Pro Val Leu Glu 
     130                135                140
Val Tyr Val Ala Ile Cys Arg Asn Leu Ile Leu Lys Leu Ala Ile Leu 
 145                150                155                160
Gly Thr Leu Cys Tyr His Trp Leu Gly Arg Arg Val Gly Val Leu Gln 
                 165                170                175
Gly Gln Cys Trp Glu Asp Phe Val Gly Gln Glu Leu Tyr Arg Phe Leu 
             180                185                190
Val Met Asp Phe Val Leu Met Leu Leu Asp Thr Leu Phe Gly Glu Leu 
         195                200                205
Val Trp Arg Ile Ile Ser Glu Lys Lys Leu Lys Arg Arg Arg Lys Pro 
     210                215                220
Glu Phe Asp Ile Ala Arg Asn Val Leu Glu Leu Ile Tyr Gly Gln Thr 
 225                230                235                240
Leu Thr Trp Leu Gly Val Leu Phe Ser Pro Leu Leu Pro Ala Val Gln 
                 245                250                255
Ile Ile Lys Leu Leu Leu Val Phe Tyr Val Lys Lys Thr Ser Leu Leu 
             260                265                270
Ala Asn Cys Gln Ala Pro Arg Arg Pro Trp Leu Ala Ser His Met Ser 
         275                280                285
Thr Val Phe Leu Thr Leu Leu Cys Phe Pro Ala Phe Leu Gly Ala Ala 
     290                295                300
Val Phe Leu Cys Tyr Ala Val Trp Gln Val Lys Pro Ser Ser Thr Cys 
 305                310                315                320
Gly Pro Phe Arg Thr Leu Asp Thr Met Tyr Glu Ala Gly Arg Val Trp 
                 325                330                335
Val Arg His Leu Glu Ala Ala Gly Pro Arg Val Ser Trp Leu Pro Trp 
             340                345                350
Val His Arg Tyr Leu Met Glu Asn Thr Phe Phe Val Phe Leu Val Ser 
         355                360                365
Ala Leu Leu Leu Ala Val Ile Tyr Leu Asn Ile Gln Val Val Arg Gly 
     370                375                380
Gln Arg Lys Val Ile Cys Leu Leu Lys Glu Gln Ile Ser Asn Glu Gly 
 385                390                395                400
Glu Asp Lys Ile Phe Leu Ile Asn Lys Leu His Ser Ile Tyr Glu Arg 
                 405                410                415
Lys Glu Arg Glu Glu Arg Ser Arg Val Gly Thr Thr Glu Glu Ala Ala 
             420                425                430
Ala Pro Pro Ala Leu Leu Thr Asp Glu Gln Asp Ala Ter 
         435                440                445



<210> 5822
<211> 559
<212> DNA
<213> Rattus norvegicus
<308> AA892531
<400> 5822

aaaaggaac  ttattgggt  ttgggttca  atgaggtcc  tgaggatgt  gtcctccat  60
acgctgggc  gcaggcccg  ctggggaac  gggccccgg  gacccccgc  cagcagcat  120
tgacctggc  gtggcgccc  ctggggtag  tgtgtgggc  aagactggg  aggtggagg  180
tgcaggagt  gcggcccta  ctgcggctg  cccaggctc  gatgtggcg  cagcaatgc  240
ggggcccct  gaggctgga  gtggtgtag  gaggcctgg  gtgggggta  cccagtctg  300
ggcggtgct  gattaagga  aaggctccg  agctggggg  tggctccag  gttctgggg  360
cgaaggatg  gtccagaag  aggtgggcc  ggggctgct  caggaggac  ttggggtgc  420
cctgttggg  cctgggtag  accttgggg  tggggctgc  ctgtagccg  agaagctcc  480
acagcaccc  gaggctgag  ctgtggtgc  cggagctgt  atagattct  cgggggcct  540
gcttggtcc  ccagaatgg  559



<210> 5823
<211> 2329
<212> DNA
<213> Homo sapiens
<308> AL136746
<400> 5823

ggctgcggc  gcagtggtg  tggcgggta  cgcacgggg  atggtcccc  ggtccgagg  60
cccggcccg  gccgggagc  tggtggccg  cgtggtgtt  gtgattgag  gtacggcca  120
cctgggacc  tacttcgag  ggctccgca  gcactacct  ctcccggcc  tcgagtatt  180
taatggtgg  cctcctgct  agacggact  cgggggaga  tatgggggg  cccagtaca  240
cctcgtggt  ttcaacaca  tggactgcg  tcccgagtc  tacgtacaa  gtcacgctc  300
caccagcag  gcctatgag  ttgtcacct  gctcgatgg  attaagttc  tgggcgggg  360
tggtgagag  tgcagcctc  tcgcggaag  actcagcac  gccttgcag  tgtttgatg  420
cttcaagaa  atgcgcgag  agattggcc  gacgcaccg  gtctgcctc  tcatctgca  480
ctcaccccc  tacttgttg  ctgctgttg  gagcaccac  tactctgga  gcacaactg  540
gaatcttgt  cagcagatt  gggagcggg  gatccactt  tccattgtg  ctccccgga  600
gctgcctgc  cttcggctt  tgtttgaga  ggcagcccc  ccggccttg  tggagccgc  660
gcagcctcc  acagatgtg  gccaggacc  gaggcacat  gtgctggtt  ggggactcg  720
gctgcctgt  gggggtggc  cagccctag  ccccctcca  tcaaagcag  cagtccccc  780
gcctcccgc  gcaccctca  gtgccactc  ctcagcagc  ccccagcag  ctctgcccc  840
cgtcccccc  cagtaccag  ttcccggga  cctgagtgc  gctcaggtg  ccgcgcaga  900
tgcagtgga  gctgccaag  accagaagg  tgggctggg  cctcgcttc  cgcccatca  960
ccctctcca  caagctgct  ccggagtgg  tcccccctt  agccaggcc  cagctcccc  1020
actaccccc  ggaccccct  gcgccccca  gccaccacc  gcttcccag  ccagtctgg  1080
ctccactgt  gcccctggc  ccggcctgg  tcccacggc  cagcccggg  caccgtcca  1140
ggcaggcac  gtggcccca  gaggggtga  cggcccttc  ccagcccag  tgggagccc  1200
agccctcgg  gggcagcag  cagtctcca  taagcttct  gcctggagc  gggtcctgg  1260
gtggcaaga  aaacccaaa  ctgcctcag  ggatgccaa  accaagctg  cgcggtcac  1320
gccctgcca  gtctacgtg  atcatggcg  gaacctgaa  acggagcag  ggccccaga  1380
gctgatcat  cagctcatc  cccagcagc  gctgaccac  ctgggccct  tgttccgga  1440
ctcaaggat  gtccagttc  atttcacca  caaggacct  gagtctctc  aaggcctct  1500
ccgcatcat  ggcaacggc  tcgcgggct  cgtgcactt  ccccacacg  cgccctgtg  1560
ggtgcgcgt  ctcatgctc  tgtactcgt  caagaagaa  atcttcatg  gcctcatcc  1620
ctacgacca  agcggcttc  tcaacggca  ccggcaggt  atcaccaac  acaagcagg  1680
ccagcagca  aagctggag  agcagcagc  aggaatggg  ggacagcag  cacccccca  1740
ggctggggc  cattctgga  gaccaagcc  ggccctcac  gaatctgct  cagctccgc  1800
caccgcagc  ccagcctca  ggtaccgta  gggcctctg  ggccacggg  cagccccag  1860
cccaaggta  tgcccagcc  ccgccaggt  cccctcaag  ccctcctgg  gcagcttct  1920
gcccacccc  tcctggacc  atccttcgg  cccagaacc  tggggccaa  cctcagctg  1980
gaagcctcc  cctcaaccc  ccaccgccg  agactgggg  gcccccacc  caggcctcc  2040
tccaccacc  gcccagtcc  ggcccgcac  acttccccc  cgggctcca  tgccaggta  2100
ggggacccg  gggagggca  aggtctgga  tgagtgtcc  agcagctcc  gggctagag  2160
accaagacc  agtgctcct  ggaagtaaa  acataggat  caagaatga  ggttccccc  2220
gccgggcct  cagcccagc  tcatggagg  cgacatcct  atggatctc  tctgaatcc  2280
caacaccca  taaagttcc  ttttaacac  aaaaaaaaa  aaaaaaaaa  2329



<210> 5824
<211> 574
<212> PRT
<213> Homo sapiens
<308> AAG15589
<400> 5824

Met Val Leu Val Arg Gly Leu Val Leu Pro Val Gly Gly Gly Ser Ala 
  1               5                  10                  15
Pro Gly Pro Leu Gln Ser Lys Gln Pro Val Pro Leu Pro Pro Ala Ala 
             20                  25                  30
Pro Ser Gly Ala Thr Leu Ser Ala Ala Pro Gln Gln Pro Leu Pro Pro 
         35                  40                  45
Val Pro Pro Gln Tyr Gln Val Pro Gly Asn Leu Ser Ala Ala Gln Val 
     50                  55                  60
Ala Ala Gln Asn Ala Val Glu Ala Ala Lys Asn Gln Lys Ala Gly Leu 
 65                  70                  75                  80
Gly Pro Arg Phe Ser Pro Ile Thr Pro Leu Gln Gln Ala Ala Pro Gly 
                 85                  90                  95
Val Gly Pro Pro Phe Ser Gln Ala Pro Ala Pro Gln Leu Pro Pro Gly 
             100                105                110
Pro Pro Gly Ala Pro Lys Pro Pro Pro Ala Ser Gln Pro Ser Leu Val 
         115                120                125
Ser Thr Val Ala Pro Gly Ser Gly Leu Ala Pro Thr Ala Gln Pro Gly 
     130                135                140
Ala Pro Ser Met Ala Gly Thr Val Ala Pro Gly Gly Val Ser Gly Pro 
 145                150                155                160
Ser Pro Ala Gln Leu Gly Ala Pro Ala Leu Gly Gly Gln Gln Ser Val 
                 165                170                175
Ser Asn Lys Leu Leu Ala Trp Ser Gly Val Leu Glu Trp Gln Glu Lys 
             180                185                190
Pro Lys Pro Ala Ser Val Asp Ala Asn Thr Lys Leu Thr Arg Ser Leu 
         195                200                205
Pro Cys Gln Val Tyr Val Asn His Gly Glu Asn Leu Lys Thr Glu Gln 
     210                215                220
Trp Pro Gln Lys Leu Ile Met Gln Leu Ile Pro Gln Gln Leu Leu Thr 
 225                230                235                240
Thr Leu Gly Pro Leu Phe Arg Asn Ser Arg Met Val Gln Phe His Phe 
                 245                250                255
Thr Asn Lys Asp Leu Glu Ser Leu Lys Gly Leu Tyr Arg Ile Met Gly 
             260                265                270
Asn Gly Phe Ala Gly Cys Val His Phe Pro His Thr Ala Pro Cys Glu 
         275                280                285
Val Arg Val Leu Met Leu Leu Tyr Ser Ser Lys Lys Lys Ile Phe Met 
     290                295                300
Gly Leu Ile Pro Tyr Asp Gln Ser Gly Phe Val Asn Gly Ile Arg Gln 
 305                310                315                320
Val Ile Thr Asn His Lys Gln Val Gln Gln Gln Lys Leu Glu Gln Gln 
                 325                330                335
Gln Arg Gly Met Gly Gly Gln Gln Ala Pro Pro Gly Leu Gly Pro Ile 
             340                345                350
Leu Glu Asp Gln Ala Arg Pro Ser Gln Asn Leu Leu Gln Leu Arg Pro 
         355                360                365
Pro Gln Pro Gln Pro Gln Gly Thr Val Gly Ala Ser Gly Ala Thr Gly 
     370                375                380
Gln Pro Gln Pro Gln Gly Thr Ala Gln Pro Pro Pro Gly Ala Pro Gln 
 385                390                395                400
Gly Pro Pro Gly Ala Ala Ser Gly Pro Pro Pro Pro Gly Pro Ile Leu 
                 405                410                415
Arg Pro Gln Asn Pro Gly Ala Asn Pro Gln Leu Arg Ser Leu Leu Leu 
             420                425                430
Asn Pro Pro Pro Pro Gln Thr Gly Val Pro Pro Pro Gln Ala Ser Leu 
         435                440                445
His His Leu Gln Pro Pro Gly Ala Pro Ala Leu Leu Pro Pro Pro His 
     450                455                460
Gln Gly Leu Gly Gln Pro Gln Leu Gly Pro Pro Leu Leu His Pro Pro 
 465                470                475                480
Pro Ala Gln Ser Trp Pro Ala Gln Leu Pro Pro Arg Ala Pro Leu Pro 
                 485                490                495
Ala Ala Lys Arg Lys Arg Glu Gly Glu Gly Arg Val Phe Arg Glu Lys 
             500                505                510
Trp Glu Arg Ala Tyr Phe Phe Val Glu Val Lys Ser Met Pro Met Cys 
         515                520                525
Leu Ile Cys Lys Gln Ile Val Ser Val Leu Lys Glu Tyr Asn Leu Lys 
     530                535                540
Arg His Tyr Glu Ser Lys His Ser Lys Ser Tyr Asp Gln Tyr Thr Glu 
 545                550                555                560
Gln Thr Arg Arg Ile Arg Ala Arg Pro Ile Trp Pro Asp Pro 
                 565                570



<210> 5825
<211> 603
<212> DNA
<213> Rattus norvegicus
<308> AA892538
<400> 5825

ggggaggaa  aggtttatt  agcttacac  tccacattg  tgttcatca  caaaggaag  60
cacacaggg  aggaagcag  agctgatgc  gaggacacg  aggggtgtt  cttactggc  120
tgctcagct  gctgttata  aagccatga  taccagccc  gggatggta  cacccacaa  180
gggctgggt  ctcccacct  gatcactaa  tgagaccct  acagctggg  ctcaggaag  240
aatttccac  actgaggct  ctttttctg  gataactcc  gcttgtatc  agttgacac  300
accagtcag  acagcaagg  aggaatgct  cttactggt  taagtatag  acccaggtc  360
accctccca  ctcaacaag  aaacaccct  aaggcttaa  tccaatctt  cagaggtag  420
ttctcagtt  agaattctt  ctgtcaggt  gctttgtca  agagagaca  acctagcta  480
cagtggttg  aaacctgcc  gagtgaaac  ctaagtgat  tctcacaga  catttccta  540
ttcatgtag  aaagcctgc  tacagtttc  tcgggcatg  tctcaagaa  tccttgctg  600
tca  603



<210> 5826
<211> 603
<212> DNA
<213> Rattus norvegicus
<308> AA892538
<400> 5826

ggggaggaa  aggtttatt  agcttacac  tccacattg  tgttcatca  caaaggaag  60
cacacaggg  aggaagcag  agctgatgc  gaggacacg  aggggtgtt  cttactggc  120
tgctcagct  gctgttata  aagccatga  taccagccc  gggatggta  cacccacaa  180
gggctgggt  ctcccacct  gatcactaa  tgagaccct  acagctggg  ctcaggaag  240
aatttccac  actgaggct  ctttttctg  gataactcc  gcttgtatc  agttgacac  300
accagtcag  acagcaagg  aggaatgct  cttactggt  taagtatag  acccaggtc  360
accctccca  ctcaacaag  aaacaccct  aaggcttaa  tccaatctt  cagaggtag  420
ttctcagtt  agaattctt  ctgtcaggt  gctttgtca  agagagaca  acctagcta  480
cagtggttg  aaacctgcc  gagtgaaac  ctaagtgat  tctcacaga  catttccta  540
ttcatgtag  aaagcctgc  tacagtttc  tcgggcatg  tctcaagaa  tccttgctg  600
tca  603



<210> 5827
<211> 584
<212> DNA
<213> Rattus norvegicus
<308> AA892547
<400> 5827

ggaaaaaat  attaaaatt  tcccaataa  ggggagaat  aacactaaa  gaccataca  60
accctggtt  caagttgat  atctcattt  tcataatat  gaagtgttc  atgttccag  120
atatgaact  gcatttgca  ttttgaaac  ccaagtcct  tctctgtaa  cccataaat  180
atgaaataa  tacctagaa  caagaatcg  ctagaagct  cggtccatg  tagagcaat  240
cgttgcgga  agacagtgc  gcaattgtc  cagtgtcac  tgctagtcc  cactgagct  300
cctcatgat  tggctgtct  ctgttgcat  agtgaagat  cttcccaca  ccacatgag  360
accccagag  ccatgacgg  tcactttac  gcagccaag  tcatcaaca  agaatccta  420
atgccggta  cgttcatct  tttcaaaaa  tgtgttgtt  gtatatggt  caaaaaatg  480
caaaccaga  gacgggtca  tgaagtcag  ccagtatcc  tcagcccga  gagcatagc  540
aatttcctt  gcaccatta  tgaacttct  caagagcgc  tctc  584



<210> 5828
<211> 455
<212> DNA
<213> Homo sapiens
<308> AI927365
<400> 5828

ttttttttt  tttttttgt  accaaatgt  tgatttatt  tgggaagaa  ataattaaa  60
ctgaggcct  tttccaata  agaggagaa  taacaatag  agatcatac  ctggttaca  120
gctaattac  acatcctat  caatgtgga  gtgttcaac  tgtattcaa  gatatgaat  180
aatgaacat  tgcaatttt  aaatcccaa  tattacata  aaatagtac  gcaaatgaa  240
ggatatttc  gctaatttc  acttaattt  ttcataata  ggctgtctg  tgttgcatt  300
gtgaagata  tccctacaa  tacatgggt  ccccagaga  tatgacgaa  cactttaca  360
catccaagg  catcaacag  gaatcctaa  tgtcggtag  gttcatcag  ttcaaaaag  420
gtgttgttt  tatatggtc  aaaaaatgc  aaacc  455



<210> 5829
<211> 296
<212> PRT
<213> Homo sapiens
<308> AAF29125
<400> 5829

Met Ala Asn Val Leu Cys Asn Arg Ala Arg Leu Val Ser Tyr Leu Pro 
  1               5                  10                  15
Gly Phe Cys Ser Leu Val Lys Arg Val Val Asn Pro Lys Ala Phe Ser 
             20                  25                  30
Thr Ala Gly Ser Ser Gly Ser Asp Glu Ser His Val Ala Ala Ala Pro 
         35                  40                  45
Pro Asp Ile Cys Ser Arg Thr Val Trp Pro Asp Glu Thr Met Gly Pro 
     50                  55                  60
Phe Gly Pro Gln Asp Gln Arg Phe Gln Leu Pro Gly Asn Ile Gly Phe 
 65                  70                  75                  80
Asp Cys His Leu Asn Gly Thr Ala Ser Gln Lys Lys Ser Leu Val His 
                 85                  90                  95
Lys Thr Leu Pro Asp Val Leu Ala Glu Pro Leu Ser Ser Glu Arg His 
             100                105                110
Glu Phe Val Met Ala Gln Tyr Val Asn Glu Phe Gln Gly Asn Asp Ala 
         115                120                125
Pro Val Glu Gln Glu Ile Asn Ser Ala Glu Thr Tyr Phe Glu Ser Ala 
     130                135                140
Arg Val Glu Cys Ala Ile Gln Thr Cys Pro Glu Leu Leu Arg Lys Asp 
 145                150                155                160
Phe Glu Ser Leu Phe Pro Glu Val Ala Asn Gly Lys Leu Met Ile Leu 
                 165                170                175
Thr Val Thr Gln Lys Thr Lys Asn Asp Met Thr Val Trp Ser Glu Glu 
             180                185                190
Val Glu Ile Glu Arg Glu Val Leu Leu Glu Lys Phe Ile Asn Gly Ala 
         195                200                205
Lys Glu Ile Cys Tyr Ala Leu Arg Ala Glu Gly Tyr Trp Ala Asp Phe 
     210                215                220
Ile Asp Pro Ser Ser Gly Leu Ala Phe Phe Gly Pro Tyr Thr Asn Asn 
 225                230                235                240
Thr Leu Phe Glu Thr Asp Glu Arg Tyr Arg His Leu Gly Phe Ser Val 
                 245                250                255
Asp Asp Leu Gly Cys Cys Lys Val Ile Arg His Ser Leu Trp Gly Thr 
             260                265                270
His Val Val Val Gly Ser Ile Phe Thr Asn Ala Thr Pro Asp Ser His 
         275                280                285
Ile Met Lys Lys Leu Ser Gly Asn 
     290                295



<210> 5830
<211> 618
<212> DNA
<213> Rattus norvegicus
<308> AA892548
<400> 5830

gaaacaaat  tttattact  tttaatgga  ccaaagggg  aacacaaag  attgaaaat  60
tcactggct  acaaatcag  caccttgtt  ccttcttgg  cacatttgt  tattcacaa  120
gtttcattc  cacatctaa  caagatacc  atccagtac  agatcataa  ggttataaa  180
gtaaacatt  gttgggaca  tgtacaata  attgcactt  cttaacaag  atcacattt  240
ccttaatag  gtgtactgc  cataataca  ggcattgtg  aaacaagta  ctggtcagt  300
tttatagag  aagaggctg  cggctaatg  tgattttat  gtcaattag  actttccag  360
ctagtcaac  cctttattc  aacatgttt  tattgtaga  gctggggaa  ataatattt  420
ataaaaata  cataaggtt  atattacct  ctcagtaag  gaaaggcag  acttggaaa  480
aaagaaatg  ggctgacaa  aaacccttt  cctaatttg  acacagcat  catgcatta  540
gtaaaaatg  caagaatag  gaaaccaat  cagggggct  atgggacat  ttggatgct  600
ggaccatct  catcttta  618



<210> 5831
<211> 451
<212> PRT
<213> Rattus norvegicus
<308> P02551
<400> 5831

Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
  1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
             20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
         35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
     50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
 65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                 85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
             100                105                110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
         115                120                125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
     130                135                140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
 145                150                155                160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                 165                170                175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
             180                185                190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
         195                200                205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
     210                215                220
Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala 
 225                230                235                240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                 245                250                255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
             260                265                270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
         275                280                285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
     290                295                300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
 305                310                315                320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                 325                330                335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
             340                345                350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
         355                360                365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
     370                375                380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
 385                390                395                400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                 405                410                415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
             420                425                430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly 
         435                440                445
Glu Glu Tyr 
     450



<210> 5832
<211> 4087
<212> DNA
<213> Homo sapiens
<308> X01703
<400> 5832

gaattcatg  cgttgggtg  agtcagcgc  cccaggctc  acttggaaa  cctttaagc  60
cttttcttt  gtaagctct  tgggcgagg  tggtggtat  ttttgtgag  tttagctta  120
ccccaaatc  tcaagcccc  ccgccgccg  tagtgcggt  caggaaccg  gccagtact  180
cgcccaggg  cagagcgct  gggaggaac  aaggcggcg  taggctgtg  tatccgaga  240
atctttcgg  ggccgcggg  agcccgtcc  gccgcgacc  agggtctgg  cgtcccggc  300
gggccccgt  tctgtgcgc  cggtttcgc  gatgctgag  ggccacttt  tgtctcgcg  360
tgttctctg  ggaccggga  aggaggagg  acccaaaaa  agcgggggc  ttgggcgag  420
tcgggggac  tgggagggg  aacgggaac  aagcgcagc  tagggttag  gtgggaaga  480
cctccgcgg  ctttggcgt  ttggaaaga  acccacaca  tcccgggaa  acatggtga  540
tttctgccc  gagcccccg  agcgggtgt  agggcggcg  ggggcgggg  tgtttgttt  600
tggcttcta  ggcgttgga  ccactgggc  cggttcgcc  cactgaacc  cttctgtca  660
gagctgact  aaaaaaaaa  aaaaaaacc  ttcatcatt  cggaactgt  ggctccaaa  720
gggttttct  cactattat  agttagatg  ctttttttt  tcttgagca  aatcataat  780
cacttcaca  gctctttaa  gtctggtct  gggacgccc  gccctgacc  actgaagtg  840
gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  gtctgtggg  cgcctgccc  gaccgactg  900
agtgtgtgt  tgtgtgtgt  tgtgtctgt  tgtctcgtc  ggactgcac  gttcagcga  960
ggagaaagg  ccactttgt  agggtaccg  tggtcagga  ccagggaaa  gcccttccc  1020
gccgccccc  cgccccgcc  ccaccacat  cagcgaata  acaattgaa  gtggtagcc  1080
taaagacca  agagaagaa  acctctatt  gatgcaaag  atatgaata  tatgtgatg  1140
gtagagaat  tcaggatga  aatactatt  tgttgtttt  aataaatat  tcattatcc  1200
tccactggg  ttttattct  tggtacctt  tcatgtgat  cttgtttct  acttaggaa  1260
ttttgtgtg  gtgtgtgta  gatacggat  atttttcag  ttttacagt  gagaagatc  1320
ggaaaaagg  tttttttta  aaaaaaaag  aatgaaatt  ctacagaca  agaagaatt  1380
tactccgct  cccgttgtc  cccgttcca  tgcatctta  ttaattcat  tcaattcag  1440
cacatggtc  cgggcggtc  gaggaggaa  actggcaaa  cagcacaat  agatcatgt  1500
ggcagctgc  ggaaataga  cttgctctg  taaataatg  agcagacag  acaggctag  1560
accaggcac  cagcaaata  agcaatgca  caatgcaga  ggcagacct  gtctaaact  1620
ctagtattg  tggattctg  agtacagat  tccggatta  aatatcaag  cctattcag  1680
ggaaacttt  atctttatt  aaaagggaa  aaagcagta  aattaatcc  aattaagtc  1740
taattggat  tacttcatt  tacaaattt  tgctttgaa  actgaatag  ttttaaata  1800
gaaaatctt  tattcaaga  tggtagtag  ccaatggct  gatacccgt  ctgacaggg  1860
caaggcgac  atcattatt  agaccacac  catatgcag  atttgtagc  ggtgatttt  1920
cttaaatct  tgtatcgtg  tggggatat  acctcaaat  atttagaaa  atatctgta  1980
attattaga  atattttga  atttcctat  atttaaatg  taatacacc  taattttac  2040
tttttcact  ttcctcccc  cagcgtgag  gcatctcca  ccacgttgg  caggctggt  2100
tccagattg  caatgcctg  tgggagctc  actgcctgg  acacggcat  cagcccgat  2160
gccagatgc  aagtgacaa  accattggg  gaggagatg  ttccttcaa  accttcttc  2220
gtgagacgg  ggctggcaa  catgtgccc  gggcagtgt  tgtagactt  gaacccaca  2280
tcattggtg  gttgacctc  gtaacccaa  tgagatccc  gggtgctgg  caggaggtc  2340
gtcctgggg  gctccgctg  tcactcacc  actctcctc  cgctcctcg  cccctcctc  2400
tcctccccc  gctcctccc  catcatgtc  ccagatgaa  ttcgcactg  cacctaccg  2460
cagctcttc  accctgagc  actcatcac  ggcaaagaa  atgctgcca  taactatgc  2520
cgagggcac  acaccattg  caaggagat  attgacctc  tgttggacc  aattcgcaa  2580
ctggtatgt  tcttttcaa  aataaagta  attaatgag  ctaaagaac  cttttgaaa  2640
aatgctttt  ttttcaaac  cagaattga  ctgttattt  aataaagag  ggaatgagt  2700
attctttgg  gtttttaaa  ttcagttaa  atgaactat  tgatgtcat  ttgtaaatg  2760
taatgagaa  tttttaaaa  catttgtca  ataagatct  agtcctgga  atgtatgaa  2820
gtgaaatat  ttactatga  gtactacaa  ataaactaa  ctttcctct  tcctctctt  2880
tgtataggc  gaccagtgc  cgcgtctcc  gggcttctt  gttttccac  gctttggtg  2940
gggaactgg  tctgggttc  cctcgctgc  catggaacg  ctctcagtt  attatggca  3000
gaagtccaa  ctggagttc  ctatttacc  ggcgcccca  gtttccaca  ctgtagttg  3060
gccctacaa  tccatcctc  ccacccaca  caccctgga  cactctgat  gtgccttca  3120
ggtagacaa  gaggccatc  atgacatct  tcgtagaaa  ctcgatatt  agcgtccaa  3180
ctatactaa  ctgaatagg  taataggtc  aattgtgtc  tccatcact  cttccctga  3240
atttgatgg  gccctgaat  ttgacctga  agaattcca  accaacctg  tgccctatc  3300
ccgcatcca  ttccctctg  ccacatatg  ccctgtcat  tctgctgag  aagcctacc  3360
tgaacagct  tctgtagca  agatcacca  tgcttgctt  gagccagcc  accagatgg  3420
gaaatgtga  cctggccat  gtaaataca  ggcttgctg  ctgttgtac  gtggtgacg  3480
ggttcccaa  gatgtcaat  ctgccattg  caccatcaa  accaagcgt  ccatccagt  3540
tgtggattg  tgccccact  gcttcaagg  tggcatcaa  taccagcct  ccactgtgg  3600
gcctggtgg  gacctggcc  aggtacaga  agctgtgtg  atgctgagc  acaccacag  3660
cattgctga  gcctgggct  gcctggacc  caagtttga  ctgatgtat  ccaaacgtg  3720
ctttgttca  tggtacgtt  gggagggga  ggaggaagg  gagttttca  aggcccgtg  3780
ggacatggc  gcccttgag  aggattatg  ggaggttgg  gtgcattct  ttgaaggag  3840
gggtgagga  gaaggagag  aatactaaa  ttaaaacgt  acaaaggtg  tgcttttac  3900
gggaagctt  ttctgtttt  aacattgaa  atgttgtgg  ctgatcagt  aatttgtat  3960
tagcagtgt  tgctctcat  tcaattact  acctatgct  taaaacatg  atgcctttg  4020
tacagaccc  agctgtcca  ttctgtgat  ggttttgaa  aaagtattc  ctgtcttaa  4080
tgaattc  4087



<210> 5833
<211> 644
<212> DNA
<213> Rattus norvegicus
<308> AA892549
<400> 5833

gagatatat  aaaagactt  attcacaat  gagaaattt  acaaatata  tttttaaaa  60
ttatgtgtc  atctattat  ttttccgta  catcagaga  ttatataaa  ttggaaaca  120
cagaatgca  ttatgaaca  atcaaaaac  atgtagaag  ggatggata  acacgacag  180
gaagtcact  agttctcta  atgagcaca  aacttatag  tataatatt  actgcacaa  240
gtataccaa  acatgtttt  taaacacaa  atcgggtgc  accttaact  ctcaccttt  300
agggcgtgg  tcatacatg  aagtcaaat  gcacagctt  gttggaaat  aatgactcg  360
catctattt  gagacttcc  ttgcttaaa  ttgacacaa  ataaaagcc  aatcaatta  420
gctactata  aatttgtct  ttatcgcgt  taaattttt  gtgttctgt  atctggcat  480
aaaaaacag  ccaagtttt  aaacagaaa  cattgctcg  cagttggag  gtagctcgt  540
gttcggctt  ctccctgct  gaaccggaa  aaacgctac  gtaccgtgg  gcaggcgca  600
aggacctga  gttcgcgtc  caaccgcta  agaaatact  acca  644



<210> 5834
<211> 566
<212> DNA
<213> Rattus norvegicus
<308> AA892550
<400> 5834

ggtgtaaaa  caaaatatg  tgatatgat  tttagaatt  tgtgataaa  actgttccc  60
tgcagtctc  ttactagga  gaggaaaac  ctaactctc  aaaaaagtg  acagtcagt  120
atatttgtt  cagcttctg  aaaaaacag  aaagcagag  aagacttct  aaaccattt  180
tttaatttt  tcatgattc  gctaaaagt  accaaccac  acttgaacc  ccaccttcc  240
ggtggcctc  caacctccc  gggcactta  gcagtggcc  cagaatctg  tcagccaca  300
cggctgctt  cactaacaa  agcctcatt  cttgacttg  gtgctcaca  tgttaacgc  360
gtccttcat  tgcgtatta  aaaatcatc  cggagtgac  tcagagcat  aatcaaagc  420
acaaaacac  caatagcta  ttttgttta  aatatttgt  tccgagatt  catttttct  480
aaaaaaaga  agccccaaa  ttacataat  tgaaatcca  tcaacaagg  agctcactt  540
gaggccccc  ggtgaacga  agccat  566



<210> 5835
<211> 1486
<212> DNA
<213> Homo sapiens
<308> AK024048
<400> 5835

agtgcgcgc  ggccgggca  ccctatgct  gcgtaatcg  gttcctccg  gccgccgta  60
gactggttc  ggcgggctg  tgaggaatg  agccggtag  ctgctgcgg  gagtgccgc  120
gctcctccg  agacccgcg  agcaccttc  tgttgagta  cctggcgga  gtggtggag  180
gtgtgctca  cttcctgcc  gccaaggcg  tgctgcggg  ggcctgcgt  tgccgctta  240
ggagggagt  tgtgcgcag  gtattgcgg  cccatcgga  cgtaacctg  atctccgca  300
gcctggcgg  ggccggcca  ctggagggg  attgcttgg  tcgcgtggt  gcagaggag  360
ttgagaatg  tcgcatctt  ccacataca  ttctttaca  ggctgattc  gaaactttc  420
ttagtctgg  agagtgtcg  ggccataag  gagcaagga  aagaactag  atggaaaca  480
cacttgccc  tgagaagct  ttccccaaa  aatgccaag  ccttgggat  gtgacccca  540
gaattgtag  gactccaat  ggatcaggt  gcaatcgac  tcaggaaat  gaaattgga  600
aatctggtt  tgctttatt  ttccctcaa  ttgaaggaa  aaaaataca  ccctttcat  660
ttattaagg  tccaaagaa  ttaacatta  aaagacatc  actcactga  gtaggtctt  720
tagataacc  tgaacttcg  gtggtcctt  tctttggtt  taattgctg  aaggtggga  780
ccagtaatt  tctgcagca  gtagtcagc  ctttcagtg  tatgaatat  atcttggct  840
gaggccagg  ggacaacct  tcatcactg  cttctgaaa  gtatgtctt  tgtgcttct  900
atttcgtct  tgaatgaag  gaaatggtc  caggttttg  cactttggg  ttaacaatt  960
aaaaaacgt  tttaaagaa  tattaagat  atagttcat  ccattttgt  gtagacatt  1020
gctaagggg  ttactgaac  taattctgc  tacggttga  taattacat  tttatatat  1080
ttgtccttc  agaacttcc  tgagtcaca  tctccttaa  atttgacat  gcctgttga  1140
ctttccttt  acagatgtg  tactctgtg  gacctcaat  tgtcacctc  tttctagtt  1200
cctccttta  aggaaacac  tggttagag  gtatcttta  ggcaaaact  ctcagagct  1260
ctaatatgc  cggtgctgt  gaaatctgg  aggagaata  cattacctg  gacagttcc  1320
aaatctgtt  ggtcacaaa  cttttttcc  cagaatgtc  tgcaagtcg  actggtttt  1380
ggaaattct  tattagatc  tttgaaagg  tttttcaag  ttaaaaatt  tggatcttt  1440
ttgttacta  ggcttttgc  ttcaaagat  aaaatattt  ctcttc  1486



<210> 5836
<211> 277
<212> PRT
<213> Homo sapiens
<308> AK024048
<400> 5836

Met Glu Pro Val Gly Cys Cys Gly Glu Cys Arg Gly Ser Ser Val Asp 
  1               5                  10                  15
Pro Arg Ser Thr Phe Val Leu Ser Asn Leu Ala Glu Val Val Glu Arg 
             20                  25                  30
Val Leu Thr Phe Leu Pro Ala Lys Ala Leu Leu Arg Val Ala Cys Val 
         35                  40                  45
Cys Arg Leu Trp Arg Glu Cys Val Arg Arg Val Leu Arg Thr His Arg 
     50                  55                  60
Ser Val Thr Trp Ile Ser Ala Gly Leu Ala Glu Ala Gly His Leu Glu 
 65                  70                  75                  80
Gly His Cys Leu Val Arg Val Val Ala Glu Glu Leu Glu Asn Val Arg 
                 85                  90                  95
Ile Leu Pro His Thr Val Leu Tyr Met Ala Asp Ser Glu Thr Phe Ile 
             100                105                110
Ser Leu Glu Glu Cys Arg Gly His Lys Arg Ala Arg Lys Arg Thr Ser 
         115                120                125
Met Glu Thr Ala Leu Ala Leu Glu Lys Leu Phe Pro Lys Gln Cys Gln 
     130                135                140
Val Leu Gly Ile Val Thr Pro Gly Ile Val Val Thr Pro Met Gly Ser 
 145                150                155                160
Gly Ser Asn Arg Pro Gln Glu Ile Glu Ile Gly Glu Ser Gly Phe Ala 
                 165                170                175
Leu Leu Phe Pro Gln Ile Glu Gly Ile Lys Ile Gln Pro Phe His Phe 
             180                185                190
Ile Lys Asp Pro Lys Asn Leu Thr Leu Glu Arg His Gln Leu Thr Glu 
         195                200                205
Val Gly Leu Leu Asp Asn Pro Glu Leu Arg Val Val Leu Val Phe Gly 
     210                215                220
Tyr Asn Cys Cys Lys Val Gly Ala Ser Asn Tyr Leu Gln Gln Val Val 
 225                230                235                240
Ser Thr Phe Ser Asp Met Asn Ile Ile Leu Ala Gly Gly Gln Val Asp 
                 245                250                255
Asn Leu Ser Ser Leu Thr Ser Glu Lys Tyr Val Leu Cys Ala Ser Asp 
             260                265                270
Phe Val Cys Glu Ter 
         275



<210> 5837
<211> 566
<212> DNA
<213> Rattus norvegicus
<308> AA892550
<400> 5837

ggtgtaaaa  caaaatatg  tgatatgat  tttagaatt  tgtgataaa  actgttccc  60
tgcagtctc  ttactagga  gaggaaaac  ctaactctc  aaaaaagtg  acagtcagt  120
atatttgtt  cagcttctg  aaaaaacag  aaagcagag  aagacttct  aaaccattt  180
tttaatttt  tcatgattc  gctaaaagt  accaaccac  acttgaacc  ccaccttcc  240
ggtggcctc  caacctccc  gggcactta  gcagtggcc  cagaatctg  tcagccaca  300
cggctgctt  cactaacaa  agcctcatt  cttgacttg  gtgctcaca  tgttaacgc  360
gtccttcat  tgcgtatta  aaaatcatc  cggagtgac  tcagagcat  aatcaaagc  420
acaaaacac  caatagcta  ttttgttta  aatatttgt  tccgagatt  catttttct  480
aaaaaaaga  agccccaaa  ttacataat  tgaaatcca  tcaacaagg  agctcactt  540
gaggccccc  ggtgaacga  agccat  566



<210> 5838
<211> 1486
<212> DNA
<213> Homo sapiens
<308> AK024048
<400> 5838

agtgcgcgc  ggccgggca  ccctatgct  gcgtaatcg  gttcctccg  gccgccgta  60
gactggttc  ggcgggctg  tgaggaatg  agccggtag  ctgctgcgg  gagtgccgc  120
gctcctccg  agacccgcg  agcaccttc  tgttgagta  cctggcgga  gtggtggag  180
gtgtgctca  cttcctgcc  gccaaggcg  tgctgcggg  ggcctgcgt  tgccgctta  240
ggagggagt  tgtgcgcag  gtattgcgg  cccatcgga  cgtaacctg  atctccgca  300
gcctggcgg  ggccggcca  ctggagggg  attgcttgg  tcgcgtggt  gcagaggag  360
ttgagaatg  tcgcatctt  ccacataca  ttctttaca  ggctgattc  gaaactttc  420
ttagtctgg  agagtgtcg  ggccataag  gagcaagga  aagaactag  atggaaaca  480
cacttgccc  tgagaagct  ttccccaaa  aatgccaag  ccttgggat  gtgacccca  540
gaattgtag  gactccaat  ggatcaggt  gcaatcgac  tcaggaaat  gaaattgga  600
aatctggtt  tgctttatt  ttccctcaa  ttgaaggaa  aaaaataca  ccctttcat  660
ttattaagg  tccaaagaa  ttaacatta  aaagacatc  actcactga  gtaggtctt  720
tagataacc  tgaacttcg  gtggtcctt  tctttggtt  taattgctg  aaggtggga  780
ccagtaatt  tctgcagca  gtagtcagc  ctttcagtg  tatgaatat  atcttggct  840
gaggccagg  ggacaacct  tcatcactg  cttctgaaa  gtatgtctt  tgtgcttct  900
atttcgtct  tgaatgaag  gaaatggtc  caggttttg  cactttggg  ttaacaatt  960
aaaaaacgt  tttaaagaa  tattaagat  atagttcat  ccattttgt  gtagacatt  1020
gctaagggg  ttactgaac  taattctgc  tacggttga  taattacat  tttatatat  1080
ttgtccttc  agaacttcc  tgagtcaca  tctccttaa  atttgacat  gcctgttga  1140
ctttccttt  acagatgtg  tactctgtg  gacctcaat  tgtcacctc  tttctagtt  1200
cctccttta  aggaaacac  tggttagag  gtatcttta  ggcaaaact  ctcagagct  1260
ctaatatgc  cggtgctgt  gaaatctgg  aggagaata  cattacctg  gacagttcc  1320
aaatctgtt  ggtcacaaa  cttttttcc  cagaatgtc  tgcaagtcg  actggtttt  1380
ggaaattct  tattagatc  tttgaaagg  tttttcaag  ttaaaaatt  tggatcttt  1440
ttgttacta  ggcttttgc  ttcaaagat  aaaatattt  ctcttc  1486



<210> 5839
<211> 277
<212> PRT
<213> Homo sapiens
<308> AK024048
<400> 5839

Met Glu Pro Val Gly Cys Cys Gly Glu Cys Arg Gly Ser Ser Val Asp 
  1               5                  10                  15
Pro Arg Ser Thr Phe Val Leu Ser Asn Leu Ala Glu Val Val Glu Arg 
             20                  25                  30
Val Leu Thr Phe Leu Pro Ala Lys Ala Leu Leu Arg Val Ala Cys Val 
         35                  40                  45
Cys Arg Leu Trp Arg Glu Cys Val Arg Arg Val Leu Arg Thr His Arg 
     50                  55                  60
Ser Val Thr Trp Ile Ser Ala Gly Leu Ala Glu Ala Gly His Leu Glu 
 65                  70                  75                  80
Gly His Cys Leu Val Arg Val Val Ala Glu Glu Leu Glu Asn Val Arg 
                 85                  90                  95
Ile Leu Pro His Thr Val Leu Tyr Met Ala Asp Ser Glu Thr Phe Ile 
             100                105                110
Ser Leu Glu Glu Cys Arg Gly His Lys Arg Ala Arg Lys Arg Thr Ser 
         115                120                125
Met Glu Thr Ala Leu Ala Leu Glu Lys Leu Phe Pro Lys Gln Cys Gln 
     130                135                140
Val Leu Gly Ile Val Thr Pro Gly Ile Val Val Thr Pro Met Gly Ser 
 145                150                155                160
Gly Ser Asn Arg Pro Gln Glu Ile Glu Ile Gly Glu Ser Gly Phe Ala 
                 165                170                175
Leu Leu Phe Pro Gln Ile Glu Gly Ile Lys Ile Gln Pro Phe His Phe 
             180                185                190
Ile Lys Asp Pro Lys Asn Leu Thr Leu Glu Arg His Gln Leu Thr Glu 
         195                200                205
Val Gly Leu Leu Asp Asn Pro Glu Leu Arg Val Val Leu Val Phe Gly 
     210                215                220
Tyr Asn Cys Cys Lys Val Gly Ala Ser Asn Tyr Leu Gln Gln Val Val 
 225                230                235                240
Ser Thr Phe Ser Asp Met Asn Ile Ile Leu Ala Gly Gly Gln Val Asp 
                 245                250                255
Asn Leu Ser Ser Leu Thr Ser Glu Lys Tyr Val Leu Cys Ala Ser Asp 
             260                265                270
Phe Val Cys Glu Ter 
         275



<210> 5840
<211> 549
<212> DNA
<213> Rattus norvegicus
<308> AA892554
<400> 5840

caacgtttg  agctgtgtg  ctttgcagc  cagcaattc  taaaccaca  tgtacagaa  60
caccagcaa  actggaatg  tgttataga  ggcaccatc  tgcttatta  attaccaga  120
aacaaaata  aggaaagac  gtttctact  tacacagtt  aaagaaagg  aaggggagg  180
gtgtgttga  cagccatcc  tccctgtac  caagagggc  ggtagaaaa  tgacaaaac  240
gagctacta  acctggtct  gtatttaag  ccacagctt  tgaagttct  gtttttgtt  300
tttcgttca  agctaaagg  cttccttct  gaatatttg  agtcttgtt  aggtttgtg  360
gcacacgct  gtcacagca  gcagataga  tgccctcat  atttcacaa  ctattctct  420
ctggaaaag  agatcaact  tttatttcc  tgttgcctc  tggtgcaga  ttcaatgtt  480
atgacttca  agtacccga  agtgcattc  gatgaatac  taacaagtt  ccgtttgtg  540
tgggggttg  549



<210> 5841
<211> 1501
<212> DNA
<213> Homo sapiens
<308> AF070615
<400> 5841

aagatgaag  gtttggtga  tctgagcct  aacttgatg  agaatcaga  gatgaagta  60
aagaggaac  agaagaaag  caaccatct  ctgaacctg  gcaagaaaa  gctaacagt  120
gttactatg  agctcaccc  gtgactaat  gcatagagg  gcctttgga  gaatcctct  180
atgaacctg  acctgagcc  gaatctgaa  caaagactg  agagctgaa  ccacaagtg  240
aggagaaga  cttagaaga  ctagaggag  aatctacta  tcctcctcc  gcagaacct  300
tttctctgc  acaagaacc  ccaaaggct  tctcctggg  ttcagtgac  agtaaaaac  360
tgcctccta  tggtactgt  tcttcctct  gaattccac  ccatgttaa  gcaccagtc  420
cacagccaa  agtcgaagc  aaaccagaa  ttcaatctc  gccacctcg  gtgcgtgaa  480
aacgaccta  agaacgacc  ggttttcct  ctagaggac  aagaccagg  agaggagat  540
tggaacaga  tgactctga  aaccgtaga  taattcgct  tccagatag  catcaactt  600
ttgttggta  cttgccaca  gatattgat  aaaatgagc  aaaggaatt  ttcatgagt  660
ttggaaacg  tgtggaact  cgcatcaat  ccaagggtg  tgggggaaa  cttccaaat  720
ttggttttg  ggtttttga  gactctgaa  cagttcaga  aatcttaat  gcaaaaccg  780
ttatgtttc  aggggaagt  cgtttaaat  tggaagaga  aaaaacaag  gctgcaaga  840
agcgagaaa  cagaggtgg  ggtgatgat  gcagggata  taggcgcaa  gatcgaggt  900
ccggtggtc  acgtggaat  gtgggtggt  gaatgatgc  tgatcgtga  ggaagagga  960
ctcctccaa  gggtggcat  gcacagaaa  ttggctctg  aagaggaac  gggcaaatg  1020
agggccgct  cacaggaca  cgtcgctga  gctccactg  tggcaaagt  ttggcagtg  1080
tacattatt  atcgtgttt  cattcttgt  aattttttt  ttggctttg  aatgtgaca  1140
agccttttt  atcatttct  tgatgtgaa  agcatcttt  gttatcagt  aaattgagg  1200
ggacattat  tccccaatt  cacaacagg  ttcacattg  taatttata  atctagact  1260
ggagaatta  ggactgaga  atgaccata  cttaaacta  ctacgacaa  gtgaactta  1320
aaggacatg  ccactgaat  caggtcctt  gagtaaaaa  aaaatcttc  gctgcacat  1380
ttgtttaag  gttactgtt  ctgcctgtt  atgctggga  cacaaatag  gcaatttgt  1440
caattggag  atcttgcct  ttttcttgg  tccccccaa  aaaaaaaaa  aaaaaaaaa  1500
a  1501



<210> 5842
<211> 482
<212> PRT
<213> Homo sapiens
<308> Q9UN86
<400> 5842

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
  1               5                  10                  15
Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
             20                  25                  30
Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
         35                  40                  45
Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
     50                  55                  60
Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
 65                  70                  75                  80
Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                 85                  90                  95
Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
             100                105                110
Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr Val His Asn 
         115                120                125
Asp Met Phe Arg Tyr Glu Asp Glu Val Phe Gly Asp Ser Glu Pro Glu 
     130                135                140
Leu Asp Glu Glu Ser Glu Asp Glu Val Glu Glu Glu Gln Glu Glu Arg 
 145                150                155                160
Gln Pro Ser Pro Glu Pro Val Gln Glu Asn Ala Asn Ser Gly Tyr Tyr 
                 165                170                175
Glu Ala His Pro Val Thr Asn Gly Ile Glu Glu Pro Leu Glu Glu Ser 
             180                185                190
Ser His Glu Pro Glu Pro Glu Pro Glu Ser Glu Thr Lys Thr Glu Glu 
         195                200                205
Leu Lys Pro Gln Val Glu Glu Lys Asn Leu Glu Glu Leu Glu Glu Lys 
     210                215                220
Ser Thr Thr Pro Pro Pro Ala Glu Pro Val Ser Leu Pro Gln Glu Pro 
 225                230                235                240
Pro Lys Ala Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro 
                 245                250                255
Ser Gly Thr Val Ser Ser Ser Gly Ile Pro Ser His Val Lys Ala Pro 
             260                265                270
Val Ser Gln Pro Arg Val Glu Ala Lys Pro Glu Val Gln Ser Gln Pro 
         275                280                285
Pro Arg Val Arg Glu Gln Arg Pro Arg Glu Arg Pro Gly Phe Pro Pro 
     290                295                300
Arg Gly Pro Arg Pro Gly Arg Gly Asp Met Glu Gln Asn Asp Ser Asp 
 305                310                315                320
Asn Arg Arg Ile Ile Arg Tyr Pro Asp Ser His Gln Leu Phe Val Gly 
                 325                330                335
Asn Leu Pro His Asp Ile Asp Glu Asn Glu Leu Lys Glu Phe Phe Met 
             340                345                350
Ser Phe Gly Asn Val Val Glu Leu Arg Ile Asn Thr Lys Gly Val Gly 
         355                360                365
Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro 
     370                375                380
Val Gln Arg Ile Leu Ile Ala Lys Pro Ile Met Phe Arg Gly Glu Val 
 385                390                395                400
Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Arg Glu 
                 405                410                415
Thr Arg Gly Gly Gly Asp Asp Arg Arg Asp Ile Arg Arg Asn Asp Arg 
             420                425                430
Gly Pro Gly Gly Pro Arg Gly Ile Val Gly Gly Gly Met Met Arg Asp 
         435                440                445
Arg Asp Gly Arg Gly Pro Pro Pro Arg Gly Gly Met Ala Gln Lys Leu 
     450                455                460
Gly Ser Gly Arg Gly Thr Gly Gln Met Glu Gly Arg Phe Thr Gly Gln 
 465                470                475                480
Arg Arg 
                 485



<210> 5843
<211> 549
<212> DNA
<213> Rattus norvegicus
<308> AA892554
<400> 5843

caacgtttg  agctgtgtg  ctttgcagc  cagcaattc  taaaccaca  tgtacagaa  60
caccagcaa  actggaatg  tgttataga  ggcaccatc  tgcttatta  attaccaga  120
aacaaaata  aggaaagac  gtttctact  tacacagtt  aaagaaagg  aaggggagg  180
gtgtgttga  cagccatcc  tccctgtac  caagagggc  ggtagaaaa  tgacaaaac  240
gagctacta  acctggtct  gtatttaag  ccacagctt  tgaagttct  gtttttgtt  300
tttcgttca  agctaaagg  cttccttct  gaatatttg  agtcttgtt  aggtttgtg  360
gcacacgct  gtcacagca  gcagataga  tgccctcat  atttcacaa  ctattctct  420
ctggaaaag  agatcaact  tttatttcc  tgttgcctc  tggtgcaga  ttcaatgtt  480
atgacttca  agtacccga  agtgcattc  gatgaatac  taacaagtt  ccgtttgtg  540
tgggggttg  549



<210> 5844
<211> 1501
<212> DNA
<213> Homo sapiens
<308> AF070615
<400> 5844

aagatgaag  gtttggtga  tctgagcct  aacttgatg  agaatcaga  gatgaagta  60
aagaggaac  agaagaaag  caaccatct  ctgaacctg  gcaagaaaa  gctaacagt  120
gttactatg  agctcaccc  gtgactaat  gcatagagg  gcctttgga  gaatcctct  180
atgaacctg  acctgagcc  gaatctgaa  caaagactg  agagctgaa  ccacaagtg  240
aggagaaga  cttagaaga  ctagaggag  aatctacta  tcctcctcc  gcagaacct  300
tttctctgc  acaagaacc  ccaaaggct  tctcctggg  ttcagtgac  agtaaaaac  360
tgcctccta  tggtactgt  tcttcctct  gaattccac  ccatgttaa  gcaccagtc  420
cacagccaa  agtcgaagc  aaaccagaa  ttcaatctc  gccacctcg  gtgcgtgaa  480
aacgaccta  agaacgacc  ggttttcct  ctagaggac  aagaccagg  agaggagat  540
tggaacaga  tgactctga  aaccgtaga  taattcgct  tccagatag  catcaactt  600
ttgttggta  cttgccaca  gatattgat  aaaatgagc  aaaggaatt  ttcatgagt  660
ttggaaacg  tgtggaact  cgcatcaat  ccaagggtg  tgggggaaa  cttccaaat  720
ttggttttg  ggtttttga  gactctgaa  cagttcaga  aatcttaat  gcaaaaccg  780
ttatgtttc  aggggaagt  cgtttaaat  tggaagaga  aaaaacaag  gctgcaaga  840
agcgagaaa  cagaggtgg  ggtgatgat  gcagggata  taggcgcaa  gatcgaggt  900
ccggtggtc  acgtggaat  gtgggtggt  gaatgatgc  tgatcgtga  ggaagagga  960
ctcctccaa  gggtggcat  gcacagaaa  ttggctctg  aagaggaac  gggcaaatg  1020
agggccgct  cacaggaca  cgtcgctga  gctccactg  tggcaaagt  ttggcagtg  1080
tacattatt  atcgtgttt  cattcttgt  aattttttt  ttggctttg  aatgtgaca  1140
agccttttt  atcatttct  tgatgtgaa  agcatcttt  gttatcagt  aaattgagg  1200
ggacattat  tccccaatt  cacaacagg  ttcacattg  taatttata  atctagact  1260
ggagaatta  ggactgaga  atgaccata  cttaaacta  ctacgacaa  gtgaactta  1320
aaggacatg  ccactgaat  caggtcctt  gagtaaaaa  aaaatcttc  gctgcacat  1380
ttgtttaag  gttactgtt  ctgcctgtt  atgctggga  cacaaatag  gcaatttgt  1440
caattggag  atcttgcct  ttttcttgg  tccccccaa  aaaaaaaaa  aaaaaaaaa  1500
a  1501



<210> 5845
<211> 482
<212> PRT
<213> Homo sapiens
<308> Q9UN86
<400> 5845

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
  1               5                  10                  15
Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
             20                  25                  30
Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
         35                  40                  45
Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
     50                  55                  60
Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
 65                  70                  75                  80
Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                 85                  90                  95
Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
             100                105                110
Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr Val His Asn 
         115                120                125
Asp Met Phe Arg Tyr Glu Asp Glu Val Phe Gly Asp Ser Glu Pro Glu 
     130                135                140
Leu Asp Glu Glu Ser Glu Asp Glu Val Glu Glu Glu Gln Glu Glu Arg 
 145                150                155                160
Gln Pro Ser Pro Glu Pro Val Gln Glu Asn Ala Asn Ser Gly Tyr Tyr 
                 165                170                175
Glu Ala His Pro Val Thr Asn Gly Ile Glu Glu Pro Leu Glu Glu Ser 
             180                185                190
Ser His Glu Pro Glu Pro Glu Pro Glu Ser Glu Thr Lys Thr Glu Glu 
         195                200                205
Leu Lys Pro Gln Val Glu Glu Lys Asn Leu Glu Glu Leu Glu Glu Lys 
     210                215                220
Ser Thr Thr Pro Pro Pro Ala Glu Pro Val Ser Leu Pro Gln Glu Pro 
 225                230                235                240
Pro Lys Ala Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro 
                 245                250                255
Ser Gly Thr Val Ser Ser Ser Gly Ile Pro Ser His Val Lys Ala Pro 
             260                265                270
Val Ser Gln Pro Arg Val Glu Ala Lys Pro Glu Val Gln Ser Gln Pro 
         275                280                285
Pro Arg Val Arg Glu Gln Arg Pro Arg Glu Arg Pro Gly Phe Pro Pro 
     290                295                300
Arg Gly Pro Arg Pro Gly Arg Gly Asp Met Glu Gln Asn Asp Ser Asp 
 305                310                315                320
Asn Arg Arg Ile Ile Arg Tyr Pro Asp Ser His Gln Leu Phe Val Gly 
                 325                330                335
Asn Leu Pro His Asp Ile Asp Glu Asn Glu Leu Lys Glu Phe Phe Met 
             340                345                350
Ser Phe Gly Asn Val Val Glu Leu Arg Ile Asn Thr Lys Gly Val Gly 
         355                360                365
Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro 
     370                375                380
Val Gln Arg Ile Leu Ile Ala Lys Pro Ile Met Phe Arg Gly Glu Val 
 385                390                395                400
Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Arg Glu 
                 405                410                415
Thr Arg Gly Gly Gly Asp Asp Arg Arg Asp Ile Arg Arg Asn Asp Arg 
             420                425                430
Gly Pro Gly Gly Pro Arg Gly Ile Val Gly Gly Gly Met Met Arg Asp 
         435                440                445
Arg Asp Gly Arg Gly Pro Pro Pro Arg Gly Gly Met Ala Gln Lys Leu 
     450                455                460
Gly Ser Gly Arg Gly Thr Gly Gln Met Glu Gly Arg Phe Thr Gly Gln 
 465                470                475                480
Arg Arg 
                 485



<210> 5846
<211> 549
<212> DNA
<213> Rattus norvegicus
<308> AA892554
<400> 5846

caacgtttg  agctgtgtg  ctttgcagc  cagcaattc  taaaccaca  tgtacagaa  60
caccagcaa  actggaatg  tgttataga  ggcaccatc  tgcttatta  attaccaga  120
aacaaaata  aggaaagac  gtttctact  tacacagtt  aaagaaagg  aaggggagg  180
gtgtgttga  cagccatcc  tccctgtac  caagagggc  ggtagaaaa  tgacaaaac  240
gagctacta  acctggtct  gtatttaag  ccacagctt  tgaagttct  gtttttgtt  300
tttcgttca  agctaaagg  cttccttct  gaatatttg  agtcttgtt  aggtttgtg  360
gcacacgct  gtcacagca  gcagataga  tgccctcat  atttcacaa  ctattctct  420
ctggaaaag  agatcaact  tttatttcc  tgttgcctc  tggtgcaga  ttcaatgtt  480
atgacttca  agtacccga  agtgcattc  gatgaatac  taacaagtt  ccgtttgtg  540
tgggggttg  549



<210> 5847
<211> 1501
<212> DNA
<213> Homo sapiens
<308> AF070615
<400> 5847

aagatgaag  gtttggtga  tctgagcct  aacttgatg  agaatcaga  gatgaagta  60
aagaggaac  agaagaaag  caaccatct  ctgaacctg  gcaagaaaa  gctaacagt  120
gttactatg  agctcaccc  gtgactaat  gcatagagg  gcctttgga  gaatcctct  180
atgaacctg  acctgagcc  gaatctgaa  caaagactg  agagctgaa  ccacaagtg  240
aggagaaga  cttagaaga  ctagaggag  aatctacta  tcctcctcc  gcagaacct  300
tttctctgc  acaagaacc  ccaaaggct  tctcctggg  ttcagtgac  agtaaaaac  360
tgcctccta  tggtactgt  tcttcctct  gaattccac  ccatgttaa  gcaccagtc  420
cacagccaa  agtcgaagc  aaaccagaa  ttcaatctc  gccacctcg  gtgcgtgaa  480
aacgaccta  agaacgacc  ggttttcct  ctagaggac  aagaccagg  agaggagat  540
tggaacaga  tgactctga  aaccgtaga  taattcgct  tccagatag  catcaactt  600
ttgttggta  cttgccaca  gatattgat  aaaatgagc  aaaggaatt  ttcatgagt  660
ttggaaacg  tgtggaact  cgcatcaat  ccaagggtg  tgggggaaa  cttccaaat  720
ttggttttg  ggtttttga  gactctgaa  cagttcaga  aatcttaat  gcaaaaccg  780
ttatgtttc  aggggaagt  cgtttaaat  tggaagaga  aaaaacaag  gctgcaaga  840
agcgagaaa  cagaggtgg  ggtgatgat  gcagggata  taggcgcaa  gatcgaggt  900
ccggtggtc  acgtggaat  gtgggtggt  gaatgatgc  tgatcgtga  ggaagagga  960
ctcctccaa  gggtggcat  gcacagaaa  ttggctctg  aagaggaac  gggcaaatg  1020
agggccgct  cacaggaca  cgtcgctga  gctccactg  tggcaaagt  ttggcagtg  1080
tacattatt  atcgtgttt  cattcttgt  aattttttt  ttggctttg  aatgtgaca  1140
agccttttt  atcatttct  tgatgtgaa  agcatcttt  gttatcagt  aaattgagg  1200
ggacattat  tccccaatt  cacaacagg  ttcacattg  taatttata  atctagact  1260
ggagaatta  ggactgaga  atgaccata  cttaaacta  ctacgacaa  gtgaactta  1320
aaggacatg  ccactgaat  caggtcctt  gagtaaaaa  aaaatcttc  gctgcacat  1380
ttgtttaag  gttactgtt  ctgcctgtt  atgctggga  cacaaatag  gcaatttgt  1440
caattggag  atcttgcct  ttttcttgg  tccccccaa  aaaaaaaaa  aaaaaaaaa  1500
a  1501



<210> 5848
<211> 482
<212> PRT
<213> Homo sapiens
<308> Q9UN86
<400> 5848

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
  1               5                  10                  15
Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
             20                  25                  30
Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
         35                  40                  45
Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
     50                  55                  60
Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
 65                  70                  75                  80
Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                 85                  90                  95
Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
             100                105                110
Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr Val His Asn 
         115                120                125
Asp Met Phe Arg Tyr Glu Asp Glu Val Phe Gly Asp Ser Glu Pro Glu 
     130                135                140
Leu Asp Glu Glu Ser Glu Asp Glu Val Glu Glu Glu Gln Glu Glu Arg 
 145                150                155                160
Gln Pro Ser Pro Glu Pro Val Gln Glu Asn Ala Asn Ser Gly Tyr Tyr 
                 165                170                175
Glu Ala His Pro Val Thr Asn Gly Ile Glu Glu Pro Leu Glu Glu Ser 
             180                185                190
Ser His Glu Pro Glu Pro Glu Pro Glu Ser Glu Thr Lys Thr Glu Glu 
         195                200                205
Leu Lys Pro Gln Val Glu Glu Lys Asn Leu Glu Glu Leu Glu Glu Lys 
     210                215                220
Ser Thr Thr Pro Pro Pro Ala Glu Pro Val Ser Leu Pro Gln Glu Pro 
 225                230                235                240
Pro Lys Ala Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro 
                 245                250                255
Ser Gly Thr Val Ser Ser Ser Gly Ile Pro Ser His Val Lys Ala Pro 
             260                265                270
Val Ser Gln Pro Arg Val Glu Ala Lys Pro Glu Val Gln Ser Gln Pro 
         275                280                285
Pro Arg Val Arg Glu Gln Arg Pro Arg Glu Arg Pro Gly Phe Pro Pro 
     290                295                300
Arg Gly Pro Arg Pro Gly Arg Gly Asp Met Glu Gln Asn Asp Ser Asp 
 305                310                315                320
Asn Arg Arg Ile Ile Arg Tyr Pro Asp Ser His Gln Leu Phe Val Gly 
                 325                330                335
Asn Leu Pro His Asp Ile Asp Glu Asn Glu Leu Lys Glu Phe Phe Met 
             340                345                350
Ser Phe Gly Asn Val Val Glu Leu Arg Ile Asn Thr Lys Gly Val Gly 
         355                360                365
Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro 
     370                375                380
Val Gln Arg Ile Leu Ile Ala Lys Pro Ile Met Phe Arg Gly Glu Val 
 385                390                395                400
Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Arg Glu 
                 405                410                415
Thr Arg Gly Gly Gly Asp Asp Arg Arg Asp Ile Arg Arg Asn Asp Arg 
             420                425                430
Gly Pro Gly Gly Pro Arg Gly Ile Val Gly Gly Gly Met Met Arg Asp 
         435                440                445
Arg Asp Gly Arg Gly Pro Pro Pro Arg Gly Gly Met Ala Gln Lys Leu 
     450                455                460
Gly Ser Gly Arg Gly Thr Gly Gln Met Glu Gly Arg Phe Thr Gly Gln 
 465                470                475                480
Arg Arg 
                 485



<210> 5849
<211> 549
<212> DNA
<213> Rattus norvegicus
<308> AA892554
<400> 5849

caacgtttg  agctgtgtg  ctttgcagc  cagcaattc  taaaccaca  tgtacagaa  60
caccagcaa  actggaatg  tgttataga  ggcaccatc  tgcttatta  attaccaga  120
aacaaaata  aggaaagac  gtttctact  tacacagtt  aaagaaagg  aaggggagg  180
gtgtgttga  cagccatcc  tccctgtac  caagagggc  ggtagaaaa  tgacaaaac  240
gagctacta  acctggtct  gtatttaag  ccacagctt  tgaagttct  gtttttgtt  300
tttcgttca  agctaaagg  cttccttct  gaatatttg  agtcttgtt  aggtttgtg  360
gcacacgct  gtcacagca  gcagataga  tgccctcat  atttcacaa  ctattctct  420
ctggaaaag  agatcaact  tttatttcc  tgttgcctc  tggtgcaga  ttcaatgtt  480
atgacttca  agtacccga  agtgcattc  gatgaatac  taacaagtt  ccgtttgtg  540
tgggggttg  549



<210> 5850
<211> 1501
<212> DNA
<213> Homo sapiens
<308> AF070615
<400> 5850

aagatgaag  gtttggtga  tctgagcct  aacttgatg  agaatcaga  gatgaagta  60
aagaggaac  agaagaaag  caaccatct  ctgaacctg  gcaagaaaa  gctaacagt  120
gttactatg  agctcaccc  gtgactaat  gcatagagg  gcctttgga  gaatcctct  180
atgaacctg  acctgagcc  gaatctgaa  caaagactg  agagctgaa  ccacaagtg  240
aggagaaga  cttagaaga  ctagaggag  aatctacta  tcctcctcc  gcagaacct  300
tttctctgc  acaagaacc  ccaaaggct  tctcctggg  ttcagtgac  agtaaaaac  360
tgcctccta  tggtactgt  tcttcctct  gaattccac  ccatgttaa  gcaccagtc  420
cacagccaa  agtcgaagc  aaaccagaa  ttcaatctc  gccacctcg  gtgcgtgaa  480
aacgaccta  agaacgacc  ggttttcct  ctagaggac  aagaccagg  agaggagat  540
tggaacaga  tgactctga  aaccgtaga  taattcgct  tccagatag  catcaactt  600
ttgttggta  cttgccaca  gatattgat  aaaatgagc  aaaggaatt  ttcatgagt  660
ttggaaacg  tgtggaact  cgcatcaat  ccaagggtg  tgggggaaa  cttccaaat  720
ttggttttg  ggtttttga  gactctgaa  cagttcaga  aatcttaat  gcaaaaccg  780
ttatgtttc  aggggaagt  cgtttaaat  tggaagaga  aaaaacaag  gctgcaaga  840
agcgagaaa  cagaggtgg  ggtgatgat  gcagggata  taggcgcaa  gatcgaggt  900
ccggtggtc  acgtggaat  gtgggtggt  gaatgatgc  tgatcgtga  ggaagagga  960
ctcctccaa  gggtggcat  gcacagaaa  ttggctctg  aagaggaac  gggcaaatg  1020
agggccgct  cacaggaca  cgtcgctga  gctccactg  tggcaaagt  ttggcagtg  1080
tacattatt  atcgtgttt  cattcttgt  aattttttt  ttggctttg  aatgtgaca  1140
agccttttt  atcatttct  tgatgtgaa  agcatcttt  gttatcagt  aaattgagg  1200
ggacattat  tccccaatt  cacaacagg  ttcacattg  taatttata  atctagact  1260
ggagaatta  ggactgaga  atgaccata  cttaaacta  ctacgacaa  gtgaactta  1320
aaggacatg  ccactgaat  caggtcctt  gagtaaaaa  aaaatcttc  gctgcacat  1380
ttgtttaag  gttactgtt  ctgcctgtt  atgctggga  cacaaatag  gcaatttgt  1440
caattggag  atcttgcct  ttttcttgg  tccccccaa  aaaaaaaaa  aaaaaaaaa  1500
a  1501



<210> 5851
<211> 482
<212> PRT
<213> Homo sapiens
<308> Q9UN86
<400> 5851

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
  1               5                  10                  15
Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
             20                  25                  30
Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
         35                  40                  45
Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
     50                  55                  60
Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
 65                  70                  75                  80
Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                 85                  90                  95
Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
             100                105                110
Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr Val His Asn 
         115                120                125
Asp Met Phe Arg Tyr Glu Asp Glu Val Phe Gly Asp Ser Glu Pro Glu 
     130                135                140
Leu Asp Glu Glu Ser Glu Asp Glu Val Glu Glu Glu Gln Glu Glu Arg 
 145                150                155                160
Gln Pro Ser Pro Glu Pro Val Gln Glu Asn Ala Asn Ser Gly Tyr Tyr 
                 165                170                175
Glu Ala His Pro Val Thr Asn Gly Ile Glu Glu Pro Leu Glu Glu Ser 
             180                185                190
Ser His Glu Pro Glu Pro Glu Pro Glu Ser Glu Thr Lys Thr Glu Glu 
         195                200                205
Leu Lys Pro Gln Val Glu Glu Lys Asn Leu Glu Glu Leu Glu Glu Lys 
     210                215                220
Ser Thr Thr Pro Pro Pro Ala Glu Pro Val Ser Leu Pro Gln Glu Pro 
 225                230                235                240
Pro Lys Ala Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro 
                 245                250                255
Ser Gly Thr Val Ser Ser Ser Gly Ile Pro Ser His Val Lys Ala Pro 
             260                265                270
Val Ser Gln Pro Arg Val Glu Ala Lys Pro Glu Val Gln Ser Gln Pro 
         275                280                285
Pro Arg Val Arg Glu Gln Arg Pro Arg Glu Arg Pro Gly Phe Pro Pro 
     290                295                300
Arg Gly Pro Arg Pro Gly Arg Gly Asp Met Glu Gln Asn Asp Ser Asp 
 305                310                315                320
Asn Arg Arg Ile Ile Arg Tyr Pro Asp Ser His Gln Leu Phe Val Gly 
                 325                330                335
Asn Leu Pro His Asp Ile Asp Glu Asn Glu Leu Lys Glu Phe Phe Met 
             340                345                350
Ser Phe Gly Asn Val Val Glu Leu Arg Ile Asn Thr Lys Gly Val Gly 
         355                360                365
Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro 
     370                375                380
Val Gln Arg Ile Leu Ile Ala Lys Pro Ile Met Phe Arg Gly Glu Val 
 385                390                395                400
Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Arg Glu 
                 405                410                415
Thr Arg Gly Gly Gly Asp Asp Arg Arg Asp Ile Arg Arg Asn Asp Arg 
             420                425                430
Gly Pro Gly Gly Pro Arg Gly Ile Val Gly Gly Gly Met Met Arg Asp 
         435                440                445
Arg Asp Gly Arg Gly Pro Pro Pro Arg Gly Gly Met Ala Gln Lys Leu 
     450                455                460
Gly Ser Gly Arg Gly Thr Gly Gln Met Glu Gly Arg Phe Thr Gly Gln 
 465                470                475                480
Arg Arg 
                 485



<210> 5852
<211> 465
<212> DNA
<213> Rattus norvegicus
<308> AA892561
<400> 5852

aagatttac  tgtttattt  ttatatgta  attcataca  tgttgctgt  ttcagacaa  60
ccaatagag  gcatcagat  ccattacag  tggttggga  ccatcttgt  gttgctggg  120
attgaactc  ggacctctg  aagagtagt  agtctctta  ccgctgagc  atgtcttca  180
ccttttacg  gaaaggtaa  tggctcctt  gttaaatct  ggcagtcga  cacagagac  240
tggacatga  caaagttgt  ctttagccc  ttctgcaaa  cttctgcga  ctcctccag  300
cttggcacg  ggaaagaaa  ctcagtgca  gccattctc  ctcctctca  caactcaga  360
acagcagct  ttggctgac  tccaccaga  ttcacaggg  accagcgtg  acagtccct  420
ctcttgtca  ccactgaat  aggtgtttg  aatcttccg  tagaa  465



<210> 5853
<211> 2403
<212> DNA
<213> Homo sapiens
<308> NM_014039
<400> 5853

ctgactaac  tgggcggag  tctagctcg  gtatcctga  gaggcgggg  tggcctagg  60
gaagatccg  actctgggt  ttttgctac  gtgaccgtt  agaacagaa  ctgttcata  120
ttggtgcgc  gtggactct  gtgataatt  accaagagt  gctctattt  tccaacctc  180
cacctaaag  agaaagaaa  tggcttgtg  tgagttttc  tttcatgta  caagtcttg  240
agagcttgc  ggagttatg  agaaggggt  aaaagataa  tttgctgat  tccaggtct  300
tgtagttga  tgccctgat  tgactaagg  accctttac  tttcctgta  aaggcatct  360
tgggaaaac  agaattgca  aagttggag  tgtgcctta  ttattgcct  ttgtaaacc  420
aaaaaaagt  tatgatctg  ataaaattg  aaaagaaat  aagctgcct  gagccttta  480
tcttggagc  ggagcaggt  catttcaga  tctcgggtt  aattctgag  ttatgccag  540
tattcagac  gaaagtgaa  acaagcctc  tgtaaatgg  agttacttt  cccatgtga  600
ccctgcaga  ggagggtgc  tactggaga  atacagtga  aaatgtcat  attttcagt  660
tgcattact  gctaatctt  ttgccagtg  aggccaacc  ggcaagcct  cagaatttt  720
ttcctgccc  ttgaactct  atgaagaag  gaataaatg  ttgcatttt  atgaaatga  780
agctccttt  gtttgtcta  cagtttttg  ctccagaga  ccagggttt  atttgcgac  840
ggagcacac  cattttttt  gtcgtcatg  agaaggtgg  cactaccat  atgacacta  900
tccagatat  gtggaatat  ttggatact  cttacctgc  gagtttctc  atcgcattg  960
tcaaccaaa  gagacgcat  caattgggc  agattaaat  agctgatac  tatttagaa  1020
aagaaataa  taaggttaa  taattgatt  acttattaa  taatactga  ataaaacca  1080
tagaaatga  cccacaggc  aggcacaat  gctcatgcc  ataatccca  cactttggg  1140
ggctgaggc  ggaagcaca  tggagccca  gagtttgag  ccagcttgg  caacatagc  1200
agaccctgt  tattttttt  aaaaagtaa  aaatagaaa  tatctcact  cttaaatcc  1260
atttttttc  cttcatatg  aagaacata  tgatagtat  ttctatatt  tttcataga  1320
ctgtctgaa  gagattggg  acaaaaata  ctaattgag  tattcttta  ttttttaca  1380
agcagcttt  tttttttta  tctgtagta  cagcgaaat  agtcatgtt  ataccttga  1440
tataaatat  aggaatcat  caattattt  tactatgta  ttagtagta  cttatattt  1500
tataacatt  ttacatttt  caaattagt  tcacaactg  taagtagat  tttctgagt  1560
ttagaaaaa  cagtgttat  acctgcagg  tattaaaaa  catttgaaa  agagaaaaa  1620
aaaaatcag  gtttagaaa  gttgatagt  attgaatct  tgaattgaa  tttaaaaat  1680
cattctagt  atcagagta  acttttttt  tagaacaag  tggcaggtg  ggagccctt  1740
acccttctg  tgaagttaa  ccatagaag  ttacaattt  cctttcaca  acattagca  1800
tccgggcat  gtggctgaa  cctgtgatc  cagcatgtt  ggaggccga  tgggaggat  1860
gcctgagcc  aggagttta  accagcctg  gcaccatgg  gagacccca  ctctattat  1920
taaaatgtt  cttaaataa  aaaaacaca  acattagca  ctagttggc  agccataat  1980
cctcccttg  ttcgattgc  agttagaag  aatttttat  tcactggtt  tttgcaaga  2040
aaggggtaa  aaaacagca  cagagtgca  cactgaagt  agcttactt  aatttgtaa  2100
tgaagctgt  gctgaacgt  accactatc  ttgctgaaa  ataaaatta  actcactga  2160
tgtaatggt  gaaattttc  tgaataatc  ttagccaaa  atcaactct  taatggtgc  2220
aatggcaat  tagctaatg  gcaaattta  gaagtcttc  gtactaagt  cataatttt  2280
aaataatat  ttttaattg  ctactttgg  tgttagcta  gtcttgtga  tataaattc  2340
aattttaag  actattttg  tgcaaaaaa  tgaataaaa  atttaattt  aaaaaaaaa  2400
aaa  2403



<210> 5854
<211> 478
<212> DNA
<213> Rattus norvegicus
<308> AA892635
<400> 5854

accataaat  ctttatttc  actagaagg  acaatctcc  aagggtttc  aagttaaaa  60
gctacaatc  catcatgtt  aaatgacat  tagaaaacc  caatgctgt  aatggacgg  120
tccgctttg  ccacgtaca  ttctgcaca  cccttatgg  ctctgcaca  agaaatcac  180
tctctccct  ctcctctta  ttgttcttg  atgtaagtt  ctttctatt  cagtatatc  240
agagtggcg  gataaccag  ccagccacg  agccaaagg  cgctccgag  gtacaggag  300
tgggccaca  cttaggagt  tttatttaa  cccctctcc  ctgctgtgt  acggctcac  360
ctggcaacc  gtaagctct  gcngtccct  ccatggtct  tcccaatcc  gtggaatan  420
aaatgctcc  agccatgct  ctatgaaac  agaaactgt  gtaatctga  gactgttc  478



<210> 5855
<211> 196
<212> PRT
<213> Rattus norvegicus
<308> TVRTRH
<400> 5855

Met Ala Ala Ile Arg Lys Lys Leu Val Val Val Gly Asp Gly Ala Cys 
  1               5                  10                  15
Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Glu Phe Pro Glu 
             20                  25                  30
Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val 
         35                  40                  45
Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
     50                  55                  60
Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
 65                  70                  75                  80
Leu Met Cys Phe Ser Val Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                 85                  90                  95
Glu Lys Trp Val Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
             100                105                110
Ile Leu Val Ala Asn Lys Lys Asp Leu Arg Ser Asp Glu His Val Arg 
         115                120                125
Thr Glu Leu Ala Arg Met Lys Gln Glu Pro Val Arg Thr Asp Asp Gly 
     130                135                140
Arg Ala Met Ala Val Arg Ile Gln Ala Tyr Asp Tyr Leu Glu Cys Ser 
 145                150                155                160
Ala Lys Thr Lys Glu Gly Val Arg Glu Val Phe Glu Thr Ala Thr Arg 
                 165                170                175
Ala Ala Leu Gln Lys Arg Tyr Gly Ser Gln Asn Gly Cys Ile Asn Cys 
             180                185                190
Cys Lys Val Leu 
         195



<210> 5856
<211> 3150
<212> DNA
<213> Homo sapiens
<308> BC013135
<400> 5856

cgagagccg  gtgcacgcg  cggggaggt  gccaacagc  gttgggacg  gacgctggt  60
cccagggga  agccagccg  tgccgcggc  ctggttcag  cggccaggc  ctagggacc  120
accatggat  ctgaacacg  caaacctga  tcatccgag  caccttcag  gaacttgaa  180
caaccggag  ctgccgcag  cctggcaag  agcggcagc  tagtgagtt  tgtacccaa  240
gcacagcgc  acatctcag  gaagaccgc  ccccggaag  accccgcag  ctcaattcg  300
agtgcgcag  ccgcagccg  cgcacgtcc  caaggcagt  agggcaccg  accctcaag  360
aaagccacc  cacgcccac  cccaaagcc  acactccca  cccccaggc  ggctggggc  420
gagcccggg  ccggggcgg  ggctccggg  ggaccatgc  cggaggccg  ccggcagca  480
catggctca  gggcccggc  cgctgatgc  caagtgcgt  gtggtcggc  acggggcgg  540
gggcaagac  tgcctactc  tgagctatg  caacgacgc  ttcccggag  agtacgtgc  600
caccgtctt  gaccactac  cagtcagcg  caccgtggg  ggcaagcag  acctcctag  660
actctatga  acggccgga  aggaagact  tgaccgtct  aggccttta  cttacccaa  720
gaccgatgt  ttccttata  gcttctcgg  ggtaaatcc  gcctcattt  aaaatgtga  780
agaggagtg  gtaccggaa  ttaaggaat  cgcaccaaa  gtacccttt  tattaatag  840
aactcagat  gatctccga  atgacccca  aactttagc  agactgaat  atatgaaag  900
aaaacctat  tgtgtggaa  aaggacaga  actagcaaa  gagatagga  catgctgct  960
tgtggaatg  tcagcttta  cccagaagg  attgaagac  gtttttgat  aggctatca  1020
agccatttt  actccaaag  aacacactg  aaaaaaaag  ataggatca  gatgtataa  1080
ctgttgttt  attacgtga  aaacatctt  agtggccaa  gaaactgtc  atttctctc  1140
gaaagcaaa  gaaatgcta  agctatacc  agacctttt  taggtaatg  agcagttca  1200
aacttgaaa  aaaacaaaa  ctgtcctca  aattctata  agtgtatta  gaatgttcc  1260
taaaggttt  agaagcagt  agcagcatc  gaagccaca  tctattata  atactttat  1320
tcaactaga  ggtacaatc  ctcaggggt  tcatagttt  aaaagctac  atcacatca  1380
gttgtaact  cgtaaaaaa  agagctgta  atggaactg  ttggctttg  ccatacaca  1440
ttctgccca  cccttacag  atctgcaca  agaaatatc  ccctttgct  cagttaatt  1500
ttcttgtat  taagttgct  tctattcca  tatatccag  gtggtgaaa  aacaaggcc  1560
gccacgtag  caaaggtcg  tccaagcgt  caggagatg  gccatacct  aggagagaa  1620
gtatgagat  aaaaaagaa  aaatgtttt  ttattactt  agcacaagt  taacctaaa  1680
atttctata  taaagctta  tgtgctttc  taaagaatg  caaaagtgt  ataaggtca  1740
aactgcatt  atcatgaac  ctaaaaatg  acacatttt  gttaatgtg  attaaactg  1800
aacaaggct  ctggcaatt  tagatttag  ttgacgctc  ccaaagtgc  tgagacaca  1860
gctaaaatt  caaattaaa  ttttgggtc  gactttgcc  taatgatag  ctcaattta  1920
ctctctgaa  tagttggta  ttttttttt  taattccca  tttggctgt  tacatcaaa  1980
gaaatgaga  gtgtgtatg  tgaccaaac  acaagaaac  ttctttaag  tgtgttaaa  2040
aggaaagac  tagaatcca  gcgtgttac  tgaaaattg  aacagagca  ctgcttcca  2100
ctttcagat  tagatgttg  aaccacagc  gaagttata  agcgacaac  tatatacac  2160
cctagaatg  aagttaaac  aaataccgg  ttccagaga  cccttttct  cagccatat  2220
acatcaggc  agaagtaat  aatgttgat  tatttcatc  acaagcagt  ggtccctaa  2280
tgaaaggct  tgcttgaaa  aaaaaagaa  aaaagttgg  ggaaaattt  catgttctt  2340
tgtgaagct  atttggtac  ctggagcca  ttctaatct  tctctgggg  gaacaggcc  2400
cagaactgt  ttagaggtg  accatctta  ttactagtt  tattaccta  ttcagcttc  2460
ttgtttggt  tgctgtgga  ctgccttat  gcatatgcc  tgcatcaga  aatggatgc  2520
tcagataat  gtgttagac  aagcttcat  gtgaacaac  taatgcatt  tagagaaac  2580
atctcatca  attttttct  gcctttcct  catttaaac  tgctgttgc  caaattata  2640
ttttttaaa  gtctttggt  ggcttctgt  aattcacat  acttgagct  atagctatg  2700
ctactgcac  gattgggta  tggaacact  aacttttat  cttgaaaat  acagcctta  2760
atgctcata  cagtcacaa  tctaggatg  actgtcttg  tgtatgtga  ctttgtaga  2820
atttttaaa  atataagca  caccttccc  ttgaagagt  gagagagtc  actggatga  2880
tggccagga  ctttctctc  gaatcggac  tttggatgt  ttctttctt  caagaaatg  2940
tggttcaca  taaagtatc  tggccttat  tatgctcaa  tggaatctt  tgtaacttt  3000
ttatttaat  ttggtctgc  tatttttag  taaaattga  aggaattgt  taaatcaat  3060
aacatatta  ctgagttgt  caacacatg  tataaacga  ttacaacag  aaactatta  3120
acatttcca  cttgcaaaa  aaaaaaaaaa  3150



<210> 5857
<211> 213
<212> PRT
<213> Homo sapiens
<308> P17081
<400> 5857

Met Pro Gly Ala Gly Arg Ser Ser Met Ala His Gly Pro Gly Ala Leu 
  1               5                  10                  15
Met Leu Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys Thr Cys 
             20                  25                  30
Leu Leu Met Ser Tyr Ala Asn Asp Ala Phe Pro Glu Glu Tyr Val Pro 
         35                  40                  45
Thr Val Phe Asp His Tyr Ala Val Ser Val Thr Val Gly Gly Lys Gln 
     50                  55                  60
Tyr Leu Leu Gly Leu Tyr Asp Thr Ala Gly Gln Glu Asp Tyr Asp Arg 
 65                  70                  75                  80
Leu Arg Pro Leu Ser Tyr Pro Met Thr Asp Val Phe Leu Ile Cys Phe 
                 85                  90                  95
Ser Val Val Asn Pro Ala Ser Phe Gln Asn Val Lys Glu Glu Trp Val 
             100                105                110
Pro Glu Leu Lys Glu Tyr Ala Pro Asn Val Pro Phe Leu Leu Ile Gly 
         115                120                125
Thr Gln Ile Asp Leu Arg Asp Asp Pro Lys Thr Leu Ala Arg Leu Asn 
     130                135                140
Asp Met Lys Glu Lys Pro Ile Cys Val Glu Gln Gly Gln Lys Leu Ala 
 145                150                155                160
Lys Glu Ile Gly Ala Cys Cys Tyr Val Glu Cys Ser Ala Leu Thr Gln 
                 165                170                175
Lys Gly Leu Lys Thr Val Phe Asp Glu Ala Ile Ile Ala Ile Leu Thr 
             180                185                190
Pro Lys Lys His Thr Val Lys Lys Arg Ile Gly Ser Arg Cys Ile Asn 
         195                200                205
Cys Cys Leu Ile Thr 
     210



<210> 5858
<211> 478
<212> DNA
<213> Rattus norvegicus
<308> AA892635
<400> 5858

accataaat  ctttatttc  actagaagg  acaatctcc  aagggtttc  aagttaaaa  60
gctacaatc  catcatgtt  aaatgacat  tagaaaacc  caatgctgt  aatggacgg  120
tccgctttg  ccacgtaca  ttctgcaca  cccttatgg  ctctgcaca  agaaatcac  180
tctctccct  ctcctctta  ttgttcttg  atgtaagtt  ctttctatt  cagtatatc  240
agagtggcg  gataaccag  ccagccacg  agccaaagg  cgctccgag  gtacaggag  300
tgggccaca  cttaggagt  tttatttaa  cccctctcc  ctgctgtgt  acggctcac  360
ctggcaacc  gtaagctct  gcngtccct  ccatggtct  tcccaatcc  gtggaatan  420
aaatgctcc  agccatgct  ctatgaaac  agaaactgt  gtaatctga  gactgttc  478



<210> 5859
<211> 196
<212> PRT
<213> Rattus norvegicus
<308> TVRTRH
<400> 5859

Met Ala Ala Ile Arg Lys Lys Leu Val Val Val Gly Asp Gly Ala Cys 
  1               5                  10                  15
Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Glu Phe Pro Glu 
             20                  25                  30
Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val 
         35                  40                  45
Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
     50                  55                  60
Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
 65                  70                  75                  80
Leu Met Cys Phe Ser Val Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                 85                  90                  95
Glu Lys Trp Val Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
             100                105                110
Ile Leu Val Ala Asn Lys Lys Asp Leu Arg Ser Asp Glu His Val Arg 
         115                120                125
Thr Glu Leu Ala Arg Met Lys Gln Glu Pro Val Arg Thr Asp Asp Gly 
     130                135                140
Arg Ala Met Ala Val Arg Ile Gln Ala Tyr Asp Tyr Leu Glu Cys Ser 
 145                150                155                160
Ala Lys Thr Lys Glu Gly Val Arg Glu Val Phe Glu Thr Ala Thr Arg 
                 165                170                175
Ala Ala Leu Gln Lys Arg Tyr Gly Ser Gln Asn Gly Cys Ile Asn Cys 
             180                185                190
Cys Lys Val Leu 
         195



<210> 5860
<211> 3150
<212> DNA
<213> Homo sapiens
<308> BC013135
<400> 5860

cgagagccg  gtgcacgcg  cggggaggt  gccaacagc  gttgggacg  gacgctggt  60
cccagggga  agccagccg  tgccgcggc  ctggttcag  cggccaggc  ctagggacc  120
accatggat  ctgaacacg  caaacctga  tcatccgag  caccttcag  gaacttgaa  180
caaccggag  ctgccgcag  cctggcaag  agcggcagc  tagtgagtt  tgtacccaa  240
gcacagcgc  acatctcag  gaagaccgc  ccccggaag  accccgcag  ctcaattcg  300
agtgcgcag  ccgcagccg  cgcacgtcc  caaggcagt  agggcaccg  accctcaag  360
aaagccacc  cacgcccac  cccaaagcc  acactccca  cccccaggc  ggctggggc  420
gagcccggg  ccggggcgg  ggctccggg  ggaccatgc  cggaggccg  ccggcagca  480
catggctca  gggcccggc  cgctgatgc  caagtgcgt  gtggtcggc  acggggcgg  540
gggcaagac  tgcctactc  tgagctatg  caacgacgc  ttcccggag  agtacgtgc  600
caccgtctt  gaccactac  cagtcagcg  caccgtggg  ggcaagcag  acctcctag  660
actctatga  acggccgga  aggaagact  tgaccgtct  aggccttta  cttacccaa  720
gaccgatgt  ttccttata  gcttctcgg  ggtaaatcc  gcctcattt  aaaatgtga  780
agaggagtg  gtaccggaa  ttaaggaat  cgcaccaaa  gtacccttt  tattaatag  840
aactcagat  gatctccga  atgacccca  aactttagc  agactgaat  atatgaaag  900
aaaacctat  tgtgtggaa  aaggacaga  actagcaaa  gagatagga  catgctgct  960
tgtggaatg  tcagcttta  cccagaagg  attgaagac  gtttttgat  aggctatca  1020
agccatttt  actccaaag  aacacactg  aaaaaaaag  ataggatca  gatgtataa  1080
ctgttgttt  attacgtga  aaacatctt  agtggccaa  gaaactgtc  atttctctc  1140
gaaagcaaa  gaaatgcta  agctatacc  agacctttt  taggtaatg  agcagttca  1200
aacttgaaa  aaaacaaaa  ctgtcctca  aattctata  agtgtatta  gaatgttcc  1260
taaaggttt  agaagcagt  agcagcatc  gaagccaca  tctattata  atactttat  1320
tcaactaga  ggtacaatc  ctcaggggt  tcatagttt  aaaagctac  atcacatca  1380
gttgtaact  cgtaaaaaa  agagctgta  atggaactg  ttggctttg  ccatacaca  1440
ttctgccca  cccttacag  atctgcaca  agaaatatc  ccctttgct  cagttaatt  1500
ttcttgtat  taagttgct  tctattcca  tatatccag  gtggtgaaa  aacaaggcc  1560
gccacgtag  caaaggtcg  tccaagcgt  caggagatg  gccatacct  aggagagaa  1620
gtatgagat  aaaaaagaa  aaatgtttt  ttattactt  agcacaagt  taacctaaa  1680
atttctata  taaagctta  tgtgctttc  taaagaatg  caaaagtgt  ataaggtca  1740
aactgcatt  atcatgaac  ctaaaaatg  acacatttt  gttaatgtg  attaaactg  1800
aacaaggct  ctggcaatt  tagatttag  ttgacgctc  ccaaagtgc  tgagacaca  1860
gctaaaatt  caaattaaa  ttttgggtc  gactttgcc  taatgatag  ctcaattta  1920
ctctctgaa  tagttggta  ttttttttt  taattccca  tttggctgt  tacatcaaa  1980
gaaatgaga  gtgtgtatg  tgaccaaac  acaagaaac  ttctttaag  tgtgttaaa  2040
aggaaagac  tagaatcca  gcgtgttac  tgaaaattg  aacagagca  ctgcttcca  2100
ctttcagat  tagatgttg  aaccacagc  gaagttata  agcgacaac  tatatacac  2160
cctagaatg  aagttaaac  aaataccgg  ttccagaga  cccttttct  cagccatat  2220
acatcaggc  agaagtaat  aatgttgat  tatttcatc  acaagcagt  ggtccctaa  2280
tgaaaggct  tgcttgaaa  aaaaaagaa  aaaagttgg  ggaaaattt  catgttctt  2340
tgtgaagct  atttggtac  ctggagcca  ttctaatct  tctctgggg  gaacaggcc  2400
cagaactgt  ttagaggtg  accatctta  ttactagtt  tattaccta  ttcagcttc  2460
ttgtttggt  tgctgtgga  ctgccttat  gcatatgcc  tgcatcaga  aatggatgc  2520
tcagataat  gtgttagac  aagcttcat  gtgaacaac  taatgcatt  tagagaaac  2580
atctcatca  attttttct  gcctttcct  catttaaac  tgctgttgc  caaattata  2640
ttttttaaa  gtctttggt  ggcttctgt  aattcacat  acttgagct  atagctatg  2700
ctactgcac  gattgggta  tggaacact  aacttttat  cttgaaaat  acagcctta  2760
atgctcata  cagtcacaa  tctaggatg  actgtcttg  tgtatgtga  ctttgtaga  2820
atttttaaa  atataagca  caccttccc  ttgaagagt  gagagagtc  actggatga  2880
tggccagga  ctttctctc  gaatcggac  tttggatgt  ttctttctt  caagaaatg  2940
tggttcaca  taaagtatc  tggccttat  tatgctcaa  tggaatctt  tgtaacttt  3000
ttatttaat  ttggtctgc  tatttttag  taaaattga  aggaattgt  taaatcaat  3060
aacatatta  ctgagttgt  caacacatg  tataaacga  ttacaacag  aaactatta  3120
acatttcca  cttgcaaaa  aaaaaaaaaa  3150



<210> 5861
<211> 213
<212> PRT
<213> Homo sapiens
<308> P17081
<400> 5861

Met Pro Gly Ala Gly Arg Ser Ser Met Ala His Gly Pro Gly Ala Leu 
  1               5                  10                  15
Met Leu Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys Thr Cys 
             20                  25                  30
Leu Leu Met Ser Tyr Ala Asn Asp Ala Phe Pro Glu Glu Tyr Val Pro 
         35                  40                  45
Thr Val Phe Asp His Tyr Ala Val Ser Val Thr Val Gly Gly Lys Gln 
     50                  55                  60
Tyr Leu Leu Gly Leu Tyr Asp Thr Ala Gly Gln Glu Asp Tyr Asp Arg 
 65                  70                  75                  80
Leu Arg Pro Leu Ser Tyr Pro Met Thr Asp Val Phe Leu Ile Cys Phe 
                 85                  90                  95
Ser Val Val Asn Pro Ala Ser Phe Gln Asn Val Lys Glu Glu Trp Val 
             100                105                110
Pro Glu Leu Lys Glu Tyr Ala Pro Asn Val Pro Phe Leu Leu Ile Gly 
         115                120                125
Thr Gln Ile Asp Leu Arg Asp Asp Pro Lys Thr Leu Ala Arg Leu Asn 
     130                135                140
Asp Met Lys Glu Lys Pro Ile Cys Val Glu Gln Gly Gln Lys Leu Ala 
 145                150                155                160
Lys Glu Ile Gly Ala Cys Cys Tyr Val Glu Cys Ser Ala Leu Thr Gln 
                 165                170                175
Lys Gly Leu Lys Thr Val Phe Asp Glu Ala Ile Ile Ala Ile Leu Thr 
             180                185                190
Pro Lys Lys His Thr Val Lys Lys Arg Ile Gly Ser Arg Cys Ile Asn 
         195                200                205
Cys Cys Leu Ile Thr 
     210



<210> 5863
<211> 506
<212> DNA
<213> Rattus norvegicus
<308> AA892642
<400> 5863

catggccaa  caaaagtat  tattagggt  tttttctta  aaacatttt  ttctaaaga  60
aaaaaacct  aaatttaaa  acctcacat  ctgccacat  agactgtat  cattattta  120
atctgtcaa  taaaacata  tacagattt  ctgacattc  gtatttcct  taaaataat  180
acagagaaa  aactttgat  agtaactac  atttgcata  tcttggcac  atttacaat  240
tggcgccta  gttgcattt  atagtttag  tcgtttttg  cccatctaa  tatcttact  300
gagaacctg  cccatcacg  gaacagaca  gtgtctccg  gcatagctt  agcaattgc  360
caatgcgaa  cctccttct  cttccatta  ctggcactg  cagcagttc  gatttttgt  420
ttcagaaat  atttctatt  tgtgttcct  atatgctat  ttcacaaca  tatttctac  480
aataatttt  agtaataac  taaatg  506



<210> 5864
<211> 3325
<212> DNA
<213> Homo sapiens
<308> AL162039
<400> 5864

aattaacaa  catgttagt  gctggtaga  gttttggag  ttaatttac  ttaaattgg  60
agactttta  ttgcagtct  tttctacct  ccctctgtt  gtcatttgt  aattctaaa  120
ggtcaccat  aaatgtatt  ggtaggaga  gatacgttt  atgtataat  tatctcaga  180
tgagttact  cctgtctta  caggatgga  aaaacacta  agtctctta  caggaaata  240
agatgatgt  gatatttat  tattacata  ataaccacc  gactccatt  tatatatta  300
cattttcct  gcttatggg  aaatagcaa  acaacattt  atttatact  ttgtttacc  360
ctctctgag  caggttttg  taaccactg  aatggtaga  tatgtgaga  acaaatatt  420
agttgtaga  ctttctttt  aaggtgaat  agtcatgcc  taacatcca  ataagagtt  480
atcttcaga  tggttcttt  gggagcact  tttattcca  ctatactgc  aaagtataa  540
gtttttgga  ctgttctag  gcataccat  aaaagcagt  tgttattat  caggaaaat  600
agtttcatc  ttttagtta  actaaacac  tttggcagc  taatatgac  tttttaaat  660
ttttttatt  tttttattt  tatttcttt  agatggagt  ttgctctgt  gcccgggct  720
gagtacaat  gcatgatct  agctcactg  aacctccac  tcctgggtt  aagcatttc  780
cctgcctca  cctcccaag  agctgggat  acaggcagc  ccacacctg  ctaattttc  840
tatttttag  agagatggg  tttcaacat  ttggccagg  tggtctcaa  ctcctgacc  900
caagtgatc  gccctcccc  gcctcccaa  gtgctggga  tacaggtgt  agccaccac  960
gccagccag  atgacctat  ttaatcatc  gctcaactg  aatttaaat  tggctgttc  1020
ctggagcta  accattagg  aagttcaaa  gaatgtgcc  tgatttccg  atttgcaca  1080
gagaatgtt  taagcattg  tagcatcat  gaataaaag  atagtttcc  gatgtcact  1140
ttttgaagt  gaaattatc  cttggatgt  gaggtttta  tttttaaaa  cattcagct  1200
aattacctt  ccttaatta  cttagttag  tatactaat  gaaaaaaac  aagtccttt  1260
tctagaact  gttttctat  tttgttcct  ttcatgaaa  cttctcaat  taattttaa  1320
tactgtagg  tagtattga  tgaatggat  ctatggaaa  gtggatcca  tatttaaga  1380
agaagtagt  taaggagac  acagccttt  ctgccattt  tttttaaat  ttttcactc  1440
gatgaacaa  ttgacttta  taaaagact  gagattttt  tacaaagaa  taggaataa  1500
tttcatata  taattatgc  gagttttaa  cctacatat  acaaaatat  tagaattgt  1560
taacctttt  atatattta  aacttttaa  gtcttttta  aagatgtgg  accaaaaat  1620
tatttataa  ttggaaatg  gactgcata  caataagaa  acttacctt  ttttgaaat  1680
tatctggga  attaaagaa  ctaccaatt  ttaaaaaca  agatttata  tttaagctt  1740
ttttaaaat  aaagaatat  taccaattc  tagaaacac  ttaaggact  ctcttaaat  1800
acttaaata  cagagtttt  ttgtaatat  aaaatttac  atggaaatc  ctgttgttc  1860
gctatcacc  taattgtgt  tgatatgat  aatgtttag  agtaaagct  tcttaagat  1920
taatggaaa  gtttaattt  aagatgtaa  aaaaattct  accacagtt  attctgaat  1980
tttaaggct  tcctaatag  ctgatcaca  agaataatc  attttgaag  tataaaact  2040
cactgtatg  ctgtcactt  tagctgaac  gattcacat  ttgacaaaa  agagaaaat  2100
caaaaatga  ttttgcaaa  gtaataact  tttctgcat  tagaactaa  taattgaaa  2160
atatgggct  tagttctca  aggtagata  taaaatcac  ggctttttc  agctgtatg  2220
ttttccact  tgcgtgtac  cacacactg  aaaataatt  ggctgattt  gcaggtctt  2280
attgttaga  attctgaag  atttactgt  aattcatag  tttcagttt  tttaggaaa  2340
tagtgtttg  cagcttttt  taaattatt  cactgaagc  gagattatt  gtgatacaa  2400
gttaaaatt  caatattta  tttctctat  tattattaa  attaaattg  tttttactt  2460
taaattcat  ttctcatct  atttaatat  aaatttgta  aggtgggcg  ttcttacca  2520
tttgcacaa  tttttgttt  tctgaaata  ttaattgtg  aggttgtaa  aaagattag  2580
gcattttca  tttaaggat  ctttgctcc  taaattgtt  gacagaaat  actttttag  2640
gaaagtagt  tttttggag  tactaactt  tatttatta  tgtacatgc  taaccaggg  2700
ggtgagggc  ctaatcttg  aggaaacac  tacttgatg  tttatttga  cttttccta  2760
aggtttaac  tttactgca  agaattaac  ctaggaaca  tgtcatgaa  tctgggttg  2820
aggagaata  agtatatat  agaacactt  aagttcaaa  agaaatcat  tctgaagac  2880
aaagcagag  aatattgtc  gtgccaagt  atggaagaa  aagggcggc  tttacactg  2940
gcaagtatt  agaagagtg  ataaagaca  ggaactact  tcatggaga  agtttctct  3000
ttataatca  gtaactaga  ggggaaaaa  catctaagt  atgaaatcc  acataggcg  3060
tatattaca  actgtgccg  attatgcaa  ttgtagttg  tactgatca  agtttaatt  3120
cttcatttt  gtttaaaaa  ggatactga  gtcagaaaa  ctgtaatat  ttttattca  3180
aagatgtaa  taatgtata  agacttgta  gtgatggga  gggaaatat  taaattcta  3240
gtgtttttt  tttttttaa  gaagaaact  aatgtttat  agaaaaaaa  gaataaata  3300
ttacgtttg  ccctgaaaa  aaaaa  3325



<210> 5865
<211> 459
<212> DNA
<213> Rattus norvegicus
<308> AA892675
<400> 5865

cggagctgg  gaccgaacc  agggccttg  gcttcctag  taagcgctc  accactgag  60
taaatcccc  gccccagtg  ctgcccctc  taaggcctg  tctcacaac  tccttacca  120
ccactttgc  agtagaaca  ccgctgtag  tgaactgct  gcccgtgct  tgggctggg  180
agaatcggc  tcggatcag  gtgtgaagc  ctccatggc  tctgtaggt  atcaaggag  240
tgtcacctg  gagcttcaa  ttcttccag  ctttcttgg  cacctgctg  cagcgatag  300
cccagttct  ctgtgtggc  gccagtcgt  acgcttcca  gccttctcg  ctggaaaag  360
gtctgatat  ccagagctt  atggtctga  ctttggagt  ggagatgag  taccgggca  420
cacccttgc  gtcaatgaa  gtgatgcca  cctggtggc  459



<210> 5866
<211> 2778
<212> DNA
<213> Homo sapiens
<308> AF267858
<400> 5866

tggtcgata  ggtgggggc  tcgaggtct  tgagtccta  ggcttctaa  tggttagat  60
agataagct  gtgaagcgc  ttcttccga  agggatttc  attggtcgg  cagagaggt  120
acctggaaa  ccaacaccg  ccaacaccc  tcccgctcc  cagtccggg  acttcgata  180
gattggaga  ggtttgtgt  cccgacgcc  tggtagttg  cataggcta  agaaaaggg  240
tctcagccc  gaggaaggg  caccctcct  gagatagct  ctaccccgt  tcaggagac  300
ctggtattt  tagagcacg  tttgctttc  ccaaaccca  ggaggtgac  ggaggagcc  360
ccgcacagg  cctaagaat  ctgtgacca  aagatggga  cgcggaaca  cagcagtgc  420
ggatccggg  ccggagacc  ctccgaggg  ttgccccga  gaggggctg  cctgcgtcg  480
agtgaggaa  aggaagaag  ggatgaaga  gtggatctg  cccaggtac  ggcctatct  540
ctccgcaga  gccaagtga  gttggtgca  ggaggaggt  cagcaaatt  acaattcat  600
caggccctc  tggactcag  ggaagagaa  gacagagct  gggatggtc  tcttgggga  660
cgatacaac  cacctgtgg  tgctacccc  gacacccgg  agctggaat  caatgagat  720
aagacacaa  tggaactgg  cacagggca  ctggggctt  ggcgggccg  ccagaagca  780
agctttcct  gaatgttgc  ccagagaga  cggggcctc  gccatcggg  aagcttctc  840
cttggagaa  agtctcgag  gatatctca  ttcttgccc  atgatctgg  cttcactga  900
agctactct  agaaggctt  ctgtggcat  tacagcaaa  atggtcaaa  attcatgtc  960
gcttgccaa  accagacaa  ccgactcta  gactgccga  atggccgtt  ccataaatt  1020
aagagcatc  aggcccgcg  cgtaggctg  agcgtcttg  atgtggcct  cacccctga  1080
gggaaccac  tcctctact  tagctggtc  gattacatt  atatctgca  tatctatgg  1140
gagggagat  cacacactg  cctggatct  aggccagat  agcgtcgct  tgctgtctt  1200
tccattgct  tctcctcag  tggacgaga  gtactagga  gggccaatg  tggctgcct  1260
tatgtcttt  accgagaac  gaaccggcg  acccttcag  ttgagtccc  tgaggatga  1320
gtgaatgca  tggcctttg  tgatataag  tcccaaatc  tgttctctg  gggagatga  1380
gccatctgc  aagtgtggg  tcgacgcac  atgcgggag  atgacccca  gcctgtggg  1440
gcactggct  gacaccagg  tggcatcac  ttcattgac  gcaagggtg  tgcccggta  1500
ctgatctcc  actctaaag  ccagaccat  aaactctgg  atatccgac  cttttccag  1560
cgggaaggc  tggaagctt  acgccaggc  gccacacag  aaaactggg  ctatcggtg  1620
cagcaagtg  ccaaaaaag  ctggcggaa  ctgaagctc  caggggaca  ctccttgat  1680
acctaccgg  gccacggag  gctgcacac  ctcatccgc  gccggttct  ccccattca  1740
agcactggc  agcagttca  ctacagtgg  tgctccact  gcaaagtgg  tgtgtacga  1800
cttctaagt  gccacattg  gaagaagct  accaaccac  aggcctgtg  gcgtgacgt  1860
agttggcac  cctttgaag  gaagattgt  agcagttcg  gggacggga  cctgcgtct  1920
tggcagtac  gccaaggct  gagtacttc  gaggatgac  tgccagaat  tgaggaatg  1980
gccagcgcc  ctgccccag  ccgccccaa  cctctacac  cttttcctc  ccccaggta  2040
atccaacct  cagccccat  tagggtgaa  ctcttgata  gctctctgc  tcctcctcc  2100
tttctccct  gtggggaat  tttggagga  tcactggca  ttgatgggg  ataacataa  2160
cctgggctc  gagcctcag  tgagccctg  aagattctc  ccatggggc  gagtggtct  2220
cttacgtgc  cacacccag  cagcttggg  ccctatctc  ggccagagt  tggcaggac  2280
ggccattat  tggggtgtg  cctctgcca  caagagaag  gtcctgggt  tttttaatc  2340
tgtttgaat  ttaggggtt  gatcctaga  tagatgcct  aggccacat  tgaacagac  2400
tgtcagcca  gcctgccag  tcttcacgt  gaggattca  ctggccaat  acaggacag  2460
tgtcctggc  tttcttcct  aggtctcta  gggaggggc  tgggtaagg  tgtttcctc  2520
gcaccctcc  ggggtgggg  ttatgtctg  tgtcatgtc  gggtcttta  ggtaggaca  2580
gctgtggta  gagaggcag  agtctccac  aggcttcat  tggcccctt  ataggcagg  2640
cctgccctc  gggaaggtc  cttcatgct  gaggcacac  gctttaagg  agtaggttg  2700
agtaggact  cttcgtcct  tcactggct  tggctccct  aataaactg  gtgggaacc  2760
gaaaaaaaa  aaaaaaaa  2778



<210> 5867
<211> 548
<212> PRT
<213> Homo sapiens
<308> AAG44727
<400> 5867

Met Gly Ser Arg Asn Ser Ser Ser Ala Gly Ser Gly Ser Gly Asp Pro 
  1               5                  10                  15
Ser Glu Gly Leu Pro Arg Arg Gly Ala Gly Leu Arg Arg Ser Glu Glu 
             20                  25                  30
Glu Glu Glu Glu Asp Glu Asp Val Asp Leu Ala Gln Val Leu Ala Tyr 
         35                  40                  45
Leu Leu Arg Arg Gly Gln Val Arg Leu Val Gln Gly Gly Gly Ala Ala 
     50                  55                  60
Asn Leu Gln Phe Ile Gln Ala Leu Leu Asp Ser Glu Glu Glu Asn Asp 
 65                  70                  75                  80
Arg Ala Trp Asp Gly Arg Leu Gly Asp Arg Tyr Asn Pro Pro Val Asp 
                 85                  90                  95
Ala Thr Pro Asp Thr Arg Glu Leu Glu Phe Asn Glu Ile Lys Thr Gln 
             100                105                110
Val Glu Leu Ala Thr Gly Gln Leu Gly Leu Arg Arg Ala Ala Gln Lys 
         115                120                125
His Ser Phe Pro Arg Met Leu His Gln Arg Glu Arg Gly Leu Cys His 
     130                135                140
Arg Gly Ser Phe Ser Leu Gly Glu Gln Ser Arg Val Ile Ser His Phe 
 145                150                155                160
Leu Pro Asn Asp Leu Gly Phe Thr Asp Ser Tyr Ser Gln Lys Ala Phe 
                 165                170                175
Cys Gly Ile Tyr Ser Lys Asp Gly Gln Ile Phe Met Ser Ala Cys Gln 
             180                185                190
Asp Gln Thr Ile Arg Leu Tyr Asp Cys Arg Tyr Gly Arg Phe His Lys 
         195                200                205
Phe Lys Ser Ile Lys Ala Arg Asp Val Gly Trp Ser Val Leu Asp Val 
     210                215                220
Ala Phe Thr Pro Asp Gly Asn His Phe Leu Tyr Ser Ser Trp Ser Asp 
 225                230                235                240
Tyr Ile His Ile Cys Asn Ile Tyr Gly Glu Gly Asp Thr His Thr Ala 
                 245                250                255
Leu Asp Leu Arg Pro Asp Glu Arg Arg Phe Ala Val Phe Ser Ile Ala 
             260                265                270
Val Ser Ser Asp Gly Arg Glu Val Leu Gly Gly Ala Asn Asp Gly Cys 
         275                280                285
Leu Tyr Val Phe Asp Arg Glu Gln Asn Arg Arg Thr Leu Gln Ile Glu 
     290                295                300
Ser His Glu Asp Asp Val Asn Ala Val Ala Phe Ala Asp Ile Ser Ser 
 305                310                315                320
Gln Ile Leu Phe Ser Gly Gly Asp Asp Ala Ile Cys Lys Val Trp Asp 
                 325                330                335
Arg Arg Thr Met Arg Glu Asp Asp Pro Lys Pro Val Gly Ala Leu Ala 
             340                345                350
Gly His Gln Asp Gly Ile Thr Phe Ile Asp Ser Lys Gly Asp Ala Arg 
         355                360                365
Tyr Leu Ile Ser Asn Ser Lys Asp Gln Thr Ile Lys Leu Trp Asp Ile 
     370                375                380
Arg Arg Phe Ser Ser Arg Glu Gly Met Glu Ala Ser Arg Gln Ala Ala 
 385                390                395                400
Thr Gln Gln Asn Trp Asp Tyr Arg Trp Gln Gln Val Pro Lys Lys Ala 
                 405                410                415
Trp Arg Lys Leu Lys Leu Pro Gly Asp Ser Ser Leu Met Thr Tyr Arg 
             420                425                430
Gly His Gly Val Leu His Thr Leu Ile Arg Cys Arg Phe Ser Pro Ile 
         435                440                445
His Ser Thr Gly Gln Gln Phe Ile Tyr Ser Gly Cys Ser Thr Gly Lys 
     450                455                460
Val Val Val Tyr Asp Leu Leu Ser Gly His Ile Val Lys Lys Leu Thr 
 465                470                475                480
Asn His Lys Ala Cys Val Arg Asp Val Ser Trp His Pro Phe Glu Glu 
                 485                490                495
Lys Ile Val Ser Ser Ser Trp Asp Gly Asn Leu Arg Leu Trp Gln Tyr 
             500                505                510
Arg Gln Gly Trp Ser Thr Ser Glu Asp Asp Met Pro Glu Ser Glu Glu 
         515                520                525
Cys Ala Ser Ala Pro Ala Pro Val Arg Pro Asn Pro Leu His Pro Phe 
     530                535                540
Pro His Pro Arg 
 545



<210> 5868
<211> 451
<212> DNA
<213> Rattus norvegicus
<308> AA892680
<400> 5868

aaaaacaag  cactgctct  tatttaaag  aaacctatt  agcgacagc  gtggcacag  60
atatgttca  gatggggcg  gaaccccag  gctcccgca  ggagcccag  actgtagat  120
ccagcagaa  gaccagtct  tgatggact  agaactgga  aaaccacac  gggcgtttc  180
cagttaagt  tttgccagt  tgtggccag  cctattaca  ctactgagc  aacgggttg  240
catgaatag  tatgtcctt  atgtgcaca  cattaagag  tctgtaagt  ttctcattt  300
ctggtaact  ctccaattc  tccaaagtc  ccagaccat  tattacctt  ccgaacact  360
tatatttca  gtccaagtg  ggctgcttg  catacgtga  gaagaactg  gatccgttg  420
tgtttgggc  attattagc  atagataca  c  451



<210> 5869
<211> 163
<212> PRT
<213> Rattus norvegicus
<308> CSRTA
<400> 5869

Val Asn Pro Thr Val Phe Phe Asp Ile Thr Ala Asp Gly Glu Pro Leu 
  1               5                  10                  15
Gly Arg Val Cys Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala 
             20                  25                  30
Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys 
         35                  40                  45
Gly Ser Ser Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly 
     50                  55                  60
Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu 
 65                  70                  75                  80
Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile 
                 85                  90                  95
Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe 
             100                105                110
Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val Phe 
         115                120                125
Gly Lys Val Lys Glu Gly Met Ser Ile Val Glu Ala Met Glu Arg Phe 
     130                135                140
Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ser Asp Cys 
 145                150                155                160
Gly Gln Leu 
                 165



<210> 5870
<211> 1137
<212> DNA
<213> Homo sapiens
<308> AF251049
<400> 5870

ggggaggaa  gaggtgagg  ggtaagggg  gttctctct  ttgggtccc  cgcccaact  60
ccgctggcc  aaagaaact  taattttga  ccaacagac  tctgctggc  tctgcgatt  120
catttttcc  gttttaaca  cggctgtgc  agacgaagt  gtgaagccc  aagacttat  180
tttgagctc  ctgtaagac  gagaaatca  gtagtcctt  ctgaaacca  taagaggaa  240
aatgtctgt  acactgcat  cagatgtag  tgatattaa  attgaagtc  tctgtgaga  300
gacacccaa  acatgtgag  tggagtctc  ctgtgtccc  caggctgga  tacaatggc  360
cgatctcgg  tcactgcaa  ctccgcctc  tgggttcaa  caagtcttc  gcctcagcc  420
cccgagaac  ggaagagga  gcaacagta  ttggggcaa  aagtttgag  atgaataca  480
tgaatatct  aagcacaat  ttagaggtg  tgtatctat  gctaataat  gcccgaaca  540
caatggatc  cagttcttc  tcacctatg  caaacagcc  catttggac  tgaaataca  600
cgtatttgg  aaggtaata  atggtctgg  aactctaga  gagttggag  agttgccag  660
aaatgagaa  acataccga  ctcttaatg  tgtacacat  aaggacata  ctattcatg  720
caacccatt  gctcagtag  tatgataga  ctggacaaa  aacttgaca  attgctgga  780
cacacttat  gtggtttac  cggttttaa  tatgtcaga  attgcatca  ccttctgct  840
gtttacaac  atgatcttc  atgaaatgg  ggtaccaag  ggcgcccaa  agcttttat  900
cccattctt  gagcatatt  tttattata  tgattatcc  acatatttc  ttaatttta  960
tacaaaaaa  acatcattt  atttttgtt  catatgaac  ttcattttt  aatgctcag  1020
ctcaagtgc  ggcattttt  agtggcctg  ttacatatt  ctcccacag  aagtccgta  1080
cctggaagt  ttattttat  ataaaattt  aaaagtttt  aggaaaaaa  aaaaaaa  1137



<210> 5871
<211> 48
<212> PRT
<213> Homo sapiens
<308> S64705
<400> 5871

Cys Leu Val Cys Gly Asp Arg Ala Ser Gly Tyr His Tyr Asn Ala Leu 
  1               5                  10                  15
Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Val Thr Lys Ser 
             20                  25                  30
Ala Val Tyr Cys Cys Lys Phe Gly Arg Ala Cys Glu Met Asp Met Tyr 
         35                  40                  45



<210> 5872
<211> 382
<212> DNA
<213> Rattus norvegicus
<308> AA892754
<400> 5872

aaaggtctc  agataattt  ttccaaatt  taatataaa  aagtaatta  cctgtatta  60
acatgcaga  caatttcag  cccttcctt  ccttcccct  cccccacac  atgaaaagg  120
atagtctgt  catgatgct  ctcggctct  gtagggaaa  tgtcactgt  ctttgtgtg  180
gctttgtgt  tctcttttc  gcagtgctg  ggcacattt  atccgacac  gttgacaca  240
gggatatag  caccaaggc  caaaaaggg  gaaggagca  caactttga  acaaagaat  300
aggaccaaa  aagccattc  tgtgcttga  gatggacac  cacacactt  aggaccctt  360
tttccttct  aaataatca  aa  382



<210> 5873
<211> 711
<212> DNA
<213> Rattus norvegicus
<308> AA892775
<400> 5873

caaactttt  ttttatttt  ttttttttt  ttgcgttga  aatcattta  tgagaatta  60
actttttct  tatcagatt  gatctgttc  agtgattat  gtctggtgt  acaagctca  120
ctgtctcag  gttggttag  gtgcatgaa  ctacttaag  aagatatgg  caagcacag  180
tcactggtc  ccctgagca  ctcacaaga  tgggaacat  ctctcaagg  ttaaaacag  240
cgggcatac  ggctgagaa  ttattttga  ggcaggata  acaggccag  tctaagaag  300
tactgtttt  aaagctcac  cgtttcata  gtttctgag  tcaggcagt  tcagttctc  360
tccactgag  cctgggccc  caaaagccc  ccaggtcca  cacagaggc  gttctaact  420
ggtgctgag  ctatacaaa  ccctggcac  cacacaact  ccattcccc  agatcaact  480
gtctcctgt  aatatgtgc  gtttgtatc  ggcacaggg  tgatgaaga  ggatcccga  540
ggagcctac  gtgcattac  tcctgatgt  cagagatgt  tgtggtgag  ctgtgcggg  600
tgctgggag  agtgtgcag  gcgttggga  actgagaag  gaaagccct  ttggtttga  660
gggaaagca  ggaaatgtg  cctttccca  agctactcc  acagtgaga  a  711



<210> 5874
<211> 148
<212> PRT
<213> Rattus norvegicus
<308> NP_036903
<400> 5874

Met Lys Ala Leu Leu Val Leu Gly Phe Leu Leu Leu Ser Ala Ser Val 
  1               5                  10                  15
Gln Ala Lys Ile Tyr Glu Arg Cys Gln Phe Ala Arg Thr Leu Lys Arg 
             20                  25                  30
Asn Gly Met Ser Gly Tyr Tyr Gly Val Ser Leu Ala Asp Trp Val Cys 
         35                  40                  45
Leu Ala Gln His Glu Ser Asn Tyr Asn Thr Gln Ala Arg Asn Tyr Asn 
     50                  55                  60
Pro Gly Asp Gln Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg 
 65                  70                  75                  80
Tyr Trp Cys Asn Asp Gly Lys Thr Pro Arg Ala Lys Asn Ala Cys Gly 
                 85                  90                  95
Ile Pro Cys Ser Ala Leu Leu Gln Asp Asp Ile Thr Gln Ala Ile Gln 
             100                105                110
Cys Ala Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val 
         115                120                125
Ala Trp Gln Arg His Cys Lys Asn Arg Asp Leu Ser Gly Tyr Ile Arg 
     130                135                140
Asn Cys Gly Val 
 145



<210> 5875
<211> 1487
<212> DNA
<213> Homo sapiens
<308> NM_000239
<400> 5875

ctagcactc  gacctagca  tcaacatga  ggctctcat  gttctgggg  ttgtcctcc  60
ttctgttac  gtccagggc  aggtctttg  aaggtgtga  ttggccaga  ctctgaaaa  120
attgggaat  gatggctac  ggggaatca  cctagcaaa  tggatgtgt  tggccaaat  180
ggagagtgg  tacaacaca  gagctacaa  ctacaatgc  ggagacaga  gcactgatt  240
tgggatatt  cagatcaat  gccgctact  gtgtaatga  ggcaaaacc  caggagcag  300
taatgcctg  catttatcc  gcagtgctt  gctgcaaga  aacatcgct  atgctgtag  360
ttgtgcaaa  agggttgtc  gtgatccac  aggcattag  gcatgggtg  catggagaa  420
tcgttgtca  aacagagat  tccgtcagt  tgttcaagg  tgtggagtg  aactccaga  480
ttttccttc  tcagctcat  ttgtctctc  cacattaag  gagtaggaa  taagtgaaa  540
gtcacacta  cattatttc  ccttcaaac  aataatatt  ttacagaag  aggagcaaa  600
tatggcctt  cttctaaga  atataatgt  cactaatgt  gttatttta  attaagcct  660
caacatttt  cagtttgca  atagaacta  tactggtga  aatttacct  aaaccttgg  720
tatcaaata  atctccagt  cattccgtt  ttttttttt  ttgagacag  ctcgctctg  780
cgcccaggc  ggagtgcag  ggcgcaatc  cggctcact  caacctcca  ctcccgggt  840
cacgccatt  tcctgcctc  gcctcccga  tagctggga  tacgggcgc  cgccaccac  900
cccggctaa  tttttgtat  tttagtaga  acagggttt  accgtgtta  ccaggatgg  960
ctcgatctc  tgaccttgt  atccaccca  ctcggcctc  caaagtgct  ggattacag  1020
cgtgagcca  tgcgcccgg  cacattcag  tcttatcaa  gaaataacc  agacttaat  1080
ttgaatgat  cgattatgc  caatattaa  taaaaaata  aagaaaagg  tatcttaaa  1140
agatcttag  caaaatacc  gctgatgaa  gcatctgat  ccttcatct  ttcagtcat  1200
tccaaaaac  gtaaaaata  ccacttttt  ttgggcaat  tgaaatttt  aaaggagta  1260
aataccaaa  gatagaaac  gactgcctg  attgagaat  ttgatttct  aaagtgtgt  1320
tctttctaa  ttgctgttc  ttaatttga  taatttaat  catgtatta  gattaaatc  1380
gaggcagat  agcttacaa  tattgaaat  attactaat  aatcacaaa  gtgaagtta  1440
gcatgatgt  aaaaataca  acattctaa  taaaggctt  gcaacac  1487



<210> 5876
<211> 148
<212> PRT
<213> Homo sapiens
<308> P00695
<400> 5876

Met Lys Ala Leu Ile Val Leu Gly Leu Val Leu Leu Ser Val Thr Val 
  1               5                  10                  15
Gln Gly Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg 
             20                  25                  30
Leu Gly Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys 
         35                  40                  45
Leu Ala Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn 
     50                  55                  60
Ala Gly Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg 
 65                  70                  75                  80
Tyr Trp Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys His 
                 85                  90                  95
Leu Ser Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala 
             100                105                110
Cys Ala Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val 
         115                120                125
Ala Trp Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln 
     130                135                140
Gly Cys Gly Val 
 145



<210> 5877
<211> 662
<212> DNA
<213> Rattus norvegicus
<308> AA892779
<400> 5877

aagtgggaa  gtcagcttt  tttataaaa  tggtcgggt  cagaggacg  catcccacc  60
ctctaaatg  ctgtaacag  cattcacat  atactcaca  agtttaact  ttcctatat  120
aaactgaac  acagtatta  aggatgagg  aagaacccc  caaggtttg  ctaagacat  180
aaaacaaac  aaccgaagc  gcctagcat  aatgatcta  tgacaacag  atgagaaac  240
aaggctcat  cctatggca  gctactgca  caaggaatg  ctggagagg  caatgctcc  300
caatgaaca  ccatttgag  aggttggtt  gtgactctg  ctgatttcg  caactaaca  360
ttataccga  tttataaac  aatccttgt  aaacaggga  gacttgcta  caaggagaa  420
atgttaaca  tcctgcctc  ctgttcagg  caactagta  acaacggca  aaaaagaac  480
taaaacctc  gctcccaaa  aactggttt  cagaattag  actctctct  aaatcaggg  540
actgccccg  agttactta  aaagttctt  atagtagaa  tgatatatt  tagttaacc  600
aagagttca  aataaatta  ccaaataac  atttgtcag  tagctgtaa  tgttacttt  660
aa  662



<210> 5878
<211> 1484
<212> DNA
<213> Homo sapiens
<308> AL136667
<400> 5878

gggggcctt  gaggcgcca  gtcccttgc  gcggcggga  agaagtcgc  tggacttcg  60
ggcggcctc  gacggccat  gcctttacc  tgtactcac  gctgcaggc  gccctgctc  120
gcgtcaacg  catcgcagt  ctgcacgag  agcgattcc  caagaacat  ggctgggga  180
cagaccagg  aattggtgg  tttggagag  agccgggaa  taaatcaca  ctaatgaac  240
ttattcgat  tgtaagaac  gtgatgaga  tgccattga  aatagtaaa  tcaattgca  300
ttgtgttac  tttattatt  ggatgaata  cagtggaga  aatggagac  cagaagagg  360
catgccagt  gaagttatt  ctttggtca  tattggaat  tttatatct  agctggctg  420
ccttgcact  gtcaaaaat  taaggctga  aataaaacc  gggtttcta  ttatctgtt  480
ttttttttt  atgttgcac  tgtagtttc  ttacaaaag  tcagatcat  aaaggcagt  540
actctccag  actggaata  ctgattgct  agtgttgat  gtagttcat  ctgtggtga  600
attgttaaa  gggtgcaag  ctgttgctt  tcttttttt  gatattttt  tatctctca  660
ttctcaggg  tggaattct  tttcaaagt  ttgaagttc  ttgcaactt  gccatgatg  720
gagtggtta  ccctagata  aattaaaag  atttttaaa  agtaattac  gcacataaa  780
tgataaata  gtaatttga  taattttat  ttaagctcc  tggttaatt  ttttgtcta  840
tgtctcagc  ataaattca  atttatacg  actattgag  attaatatt  tctgatttc  900
gggagaatt  tgtcagtca  atgatgatt  tgtttttgt  taacattct  tccatgcac  960
tgttatttt  ttaatttgc  tgaatgatg  gaccagacc  gtgtctaca  attttcatt  1020
tcagaaaaa  ctataagtc  gcccttttt  caatgatga  ttaaaaaaa  caacagcgt  1080
aatattagc  cacaagagc  gtcctaaac  atcacaatt  cactgtact  cccaagaag  1140
ctgtttatt  tgaagcatt  acctttcaa  aaatcatta  atttctatt  cttggtgga  1200
cagcacatt  tggagtgtg  ttcttaatt  ttcattgag  ttgtcaata  gacattgat  1260
ctggatagg  tgtcttttg  atttatgtc  cagaccatc  tgtgagatt  tttgcctat  1320
tcataatac  gttttatgc  gaaaggttg  aactatgta  atggttttt  tggaaatta  1380
cagttacaa  attttaaag  tgtagaatg  catctttgt  tataggaga  catttgtaa  1440
taaagttaa  tttctaagt  aaaaaaaaa  aaaaaaaaa  aaaa  1484



<210> 5879
<211> 83
<212> PRT
<213> Homo sapiens
<308> AL136667
<400> 5879

Met Ala Phe Thr Leu Tyr Ser Leu Leu Gln Ala Ala Leu Leu Cys Val 
  1               5                  10                  15
Asn Ala Ile Ala Val Leu His Glu Glu Arg Phe Leu Lys Asn Ile Gly 
             20                  25                  30
Trp Gly Thr Asp Gln Gly Ile Gly Gly Phe Gly Glu Glu Pro Gly Ile 
         35                  40                  45
Lys Ser Gln Leu Met Asn Leu Ile Arg Ser Val Arg Thr Val Met Arg 
     50                  55                  60
Val Pro Leu Ile Ile Val Asn Ser Ile Ala Ile Val Leu Leu Leu Leu 
 65                  70                  75                  80
Phe Gly Ter 
                 85



<210> 5880
<211> 662
<212> DNA
<213> Rattus norvegicus
<308> AA892779
<400> 5880

aagtgggaa  gtcagcttt  tttataaaa  tggtcgggt  cagaggacg  catcccacc  60
ctctaaatg  ctgtaacag  cattcacat  atactcaca  agtttaact  ttcctatat  120
aaactgaac  acagtatta  aggatgagg  aagaacccc  caaggtttg  ctaagacat  180
aaaacaaac  aaccgaagc  gcctagcat  aatgatcta  tgacaacag  atgagaaac  240
aaggctcat  cctatggca  gctactgca  caaggaatg  ctggagagg  caatgctcc  300
caatgaaca  ccatttgag  aggttggtt  gtgactctg  ctgatttcg  caactaaca  360
ttataccga  tttataaac  aatccttgt  aaacaggga  gacttgcta  caaggagaa  420
atgttaaca  tcctgcctc  ctgttcagg  caactagta  acaacggca  aaaaagaac  480
taaaacctc  gctcccaaa  aactggttt  cagaattag  actctctct  aaatcaggg  540
actgccccg  agttactta  aaagttctt  atagtagaa  tgatatatt  tagttaacc  600
aagagttca  aataaatta  ccaaataac  atttgtcag  tagctgtaa  tgttacttt  660
aa  662



<210> 5881
<211> 1484
<212> DNA
<213> Homo sapiens
<308> AL136667
<400> 5881

gggggcctt  gaggcgcca  gtcccttgc  gcggcggga  agaagtcgc  tggacttcg  60
ggcggcctc  gacggccat  gcctttacc  tgtactcac  gctgcaggc  gccctgctc  120
gcgtcaacg  catcgcagt  ctgcacgag  agcgattcc  caagaacat  ggctgggga  180
cagaccagg  aattggtgg  tttggagag  agccgggaa  taaatcaca  ctaatgaac  240
ttattcgat  tgtaagaac  gtgatgaga  tgccattga  aatagtaaa  tcaattgca  300
ttgtgttac  tttattatt  ggatgaata  cagtggaga  aatggagac  cagaagagg  360
catgccagt  gaagttatt  ctttggtca  tattggaat  tttatatct  agctggctg  420
ccttgcact  gtcaaaaat  taaggctga  aataaaacc  gggtttcta  ttatctgtt  480
ttttttttt  atgttgcac  tgtagtttc  ttacaaaag  tcagatcat  aaaggcagt  540
actctccag  actggaata  ctgattgct  agtgttgat  gtagttcat  ctgtggtga  600
attgttaaa  gggtgcaag  ctgttgctt  tcttttttt  gatattttt  tatctctca  660
ttctcaggg  tggaattct  tttcaaagt  ttgaagttc  ttgcaactt  gccatgatg  720
gagtggtta  ccctagata  aattaaaag  atttttaaa  agtaattac  gcacataaa  780
tgataaata  gtaatttga  taattttat  ttaagctcc  tggttaatt  ttttgtcta  840
tgtctcagc  ataaattca  atttatacg  actattgag  attaatatt  tctgatttc  900
gggagaatt  tgtcagtca  atgatgatt  tgtttttgt  taacattct  tccatgcac  960
tgttatttt  ttaatttgc  tgaatgatg  gaccagacc  gtgtctaca  attttcatt  1020
tcagaaaaa  ctataagtc  gcccttttt  caatgatga  ttaaaaaaa  caacagcgt  1080
aatattagc  cacaagagc  gtcctaaac  atcacaatt  cactgtact  cccaagaag  1140
ctgtttatt  tgaagcatt  acctttcaa  aaatcatta  atttctatt  cttggtgga  1200
cagcacatt  tggagtgtg  ttcttaatt  ttcattgag  ttgtcaata  gacattgat  1260
ctggatagg  tgtcttttg  atttatgtc  cagaccatc  tgtgagatt  tttgcctat  1320
tcataatac  gttttatgc  gaaaggttg  aactatgta  atggttttt  tggaaatta  1380
cagttacaa  attttaaag  tgtagaatg  catctttgt  tataggaga  catttgtaa  1440
taaagttaa  tttctaagt  aaaaaaaaa  aaaaaaaaa  aaaa  1484



<210> 5882
<211> 83
<212> PRT
<213> Homo sapiens
<308> AL136667
<400> 5882

Met Ala Phe Thr Leu Tyr Ser Leu Leu Gln Ala Ala Leu Leu Cys Val 
  1               5                  10                  15
Asn Ala Ile Ala Val Leu His Glu Glu Arg Phe Leu Lys Asn Ile Gly 
             20                  25                  30
Trp Gly Thr Asp Gln Gly Ile Gly Gly Phe Gly Glu Glu Pro Gly Ile 
         35                  40                  45
Lys Ser Gln Leu Met Asn Leu Ile Arg Ser Val Arg Thr Val Met Arg 
     50                  55                  60
Val Pro Leu Ile Ile Val Asn Ser Ile Ala Ile Val Leu Leu Leu Leu 
 65                  70                  75                  80
Phe Gly Ter 
                 85



<210> 5883
<211> 558
<212> DNA
<213> Rattus norvegicus
<308> AA892780
<400> 5883

caatagaga  atgtttaat  agacttgct  agactggag  cttagatcc  ccctgtgcc  60
catacccaa  acagaaaaa  gtttctata  agtgaacac  tttaagtag  aagtagtag  120
aagagggag  ccctgagac  agcctggag  gtgaggtaa  gcagtggtg  actcctctg  180
gggccaggc  tgggaaaga  gggagctct  cttgcaaag  ccttgctgc  acctttgta  240
aggggggga  aggatggag  tgtccttga  gatcaagcc  gtagtgggg  gatcacagc  300
gtgcaagtg  ggctttcca  aaggacaga  ggctaaaaa  gaccgtcac  aggaagtgt  360
acccccaac  ccagagttc  ttccactag  tctggtggg  gcactctag  cttcactgt  420
acacaggac  ctaaacatg  gtcaagcca  ctgcaaggt  ccgactgct  tttgtcaac  480
cgggggcta  gccgctttc  tcctttttg  acgcttagc  cagcccctg  cgaaccagc  540
tcctacgat  ggggtggc  558



<210> 5884
<211> 528
<212> DNA
<213> Rattus norvegicus
<308> AA892801
<400> 5884

caaccacag  agagtttat  actccaatg  ttcgcacag  tgggttgca  gtctaaggg  60
tgcctgcct  cctggaggc  ctcccccac  tccccctct  ggggaatta  acttggcca  120
atacatctc  gcaaactgc  tcagtgtga  ggcccaccc  tgcaggcca  agccaaagc  180
tacagtgcc  aggacagga  cgatcatga  attgcccat  ggtccactc  cgccctcgc  240
ataggtgga  atgatgaca  tgacgttct  cacgatgcg  tggaaggtc  ggtagagct  300
ctcaggctc  agttgcagt  ccagcaggg  ccggtccat  ttgttcatc  tcagcacgg  360
cttgatgcg  tcagcgatg  cctgccgca  cactgtctc  gtctgcaca  agacaccag  420
cacacagtc  accaccacc  gtgctccat  agtgacacg  agagcagcg  tcacctctg  480
ggagaagtc  acatgacct  gagagtcaa  gaggttgat  ctcgtgcc  528



<210> 5885
<211> 857
<212> PRT
<213> Rattus norvegicus
<308> P05197
<400> 5885

Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys Ala 
  1               5                  10                  15
Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys Ser 
             20                  25                  30
Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser Ala 
         35                  40                  45
Arg Ala Gly Glu Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln Glu 
     50                  55                  60
Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu Leu 
 65                  70                  75                  80
Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ser Gly 
                 85                  90                  95
Phe Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser Ser 
             100                105                110
Glu Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val Val 
         115                120                125
Asp Cys Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg Gln 
     130                135                140
Ala Ile Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met Asp 
 145                150                155                160
Arg Ala Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln Thr 
                 165                170                175
Phe Gln Arg Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr Gly 
             180                185                190
Glu Gly Glu Ser Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val Leu 
         195                200                205
Gly Thr Val Gly Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr Leu 
     210                215                220
Lys Gln Phe Ala Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly Glu 
 225                230                235                240
Gly Gln Leu Gly Ala Ala Glu Arg Ala Lys Lys Val Glu Asp Met Met 
                 245                250                255
Lys Lys Leu Trp Gly Asp Arg Tyr Phe Asp Pro Ala Asn Gly Lys Phe 
             260                265                270
Ser Lys Ser Ala Asn Ser Pro Asp Gly Lys Lys Leu Pro Arg Thr Phe 
         275                280                285
Cys Gln Leu Ile Leu Asp Pro Ile Phe Lys Val Phe Asp Ala Ile Met 
     290                295                300
Asn Phe Arg Lys Glu Glu Thr Ala Lys Leu Ile Glu Lys Leu Asp Ile 
 305                310                315                320
Lys Leu Asp Ser Glu Asp Lys Asp Lys Glu Gly Lys Pro Leu Leu Lys 
                 325                330                335
Ala Val Met Arg Arg Trp Leu Pro Ala Gly Asp Ala Leu Leu Gln Met 
             340                345                350
Ile Thr Ile His Leu Pro Ser Pro Val Thr Ala Gln Lys Tyr Arg Cys 
         355                360                365
Glu Leu Leu Tyr Glu Gly Pro Pro Asp Asp Glu Ala Ala Met Gly Ile 
     370                375                380
Lys Ser Cys Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys Met 
 385                390                395                400
Val Pro Thr Ser Asp Lys Gly Arg Phe Tyr Ala Phe Gly Arg Val Phe 
                 405                410                415
Ser Gly Val Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro Asn 
             420                425                430
Tyr Thr Pro Gly Lys Lys Glu Asp Leu Tyr Leu Lys Pro Ile Gln Arg 
         435                440                445
Thr Ile Leu Met Met Gly Arg Tyr Val Glu Pro Ile Glu Asp Val Pro 
     450                455                460
Cys Gly Asn Ile Val Gly Leu Val Gly Val Asp Gln Phe Leu Val Lys 
 465                470                475                480
Thr Gly Thr Ile Thr Thr Phe Glu His Ala His Asn Met Arg Val Met 
                 485                490                495
Lys Phe Ser Val Ser Pro Val Val Arg Val Ala Val Glu Ala Lys Asn 
             500                505                510
Pro Ala Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg Leu Ala Lys 
         515                520                525
Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly Glu His Ile 
     530                535                540
Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu Lys Asp Leu 
 545                550                555                560
Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp Pro Val Val 
                 565                570                575
Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu Cys Leu Ser 
             580                585                590
Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala Arg Pro Phe 
         595                600                605
Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val Ser Ala Arg 
     610                615                620
Gln Glu Leu Lys Ala Arg Ala Arg Tyr Leu Ala Glu Lys Tyr Glu Trp 
 625                630                635                640
Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro Asp Gly Thr 
                 645                650                655
Gly Pro Asn Ile Leu Thr Asp Ile Thr Lys Gly Val Gln Tyr Leu Asn 
             660                665                670
Glu Ile Lys Asp Ser Val Val Ala Gly Phe Gln Trp Ala Thr Lys Glu 
         675                680                685
Gly Ala Leu Cys Glu Glu Asn Met Arg Gly Val Arg Phe Asp Val His 
     690                695                700
Asp Val Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln Ile 
 705                710                715                720
Ile Pro Thr Ala Arg Arg Cys Leu Tyr Ala Ser Val Leu Thr Ala Gln 
                 725                730                735
Pro Arg Leu Met Glu Pro Ile Tyr Leu Val Glu Ile Gln Cys Pro Glu 
             740                745                750
Gln Val Val Gly Gly Ile Tyr Gly Val Leu Asn Arg Lys Arg Gly His 
         755                760                765
Val Phe Glu Glu Ser Gln Val Ala Gly Thr Pro Met Phe Val Val Lys 
     770                775                780
Ala Tyr Leu Pro Val Asn Glu Ser Phe Gly Phe Thr Ala Asp Leu Arg 
 785                790                795                800
Ser Asn Thr Gly Gly Gln Ala Phe Pro Gln Cys Val Phe Asp His Trp 
                 805                810                815
Gln Ile Leu Pro Gly Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser Gln 
             820                825                830
Val Val Ala Glu Thr Arg Lys Arg Lys Gly Leu Lys Glu Gly Ile Pro 
         835                840                845
Ala Leu Asp Asn Phe Leu Asp Lys Leu 
     850                855



<210> 5886
<211> 1573
<212> DNA
<213> Homo sapiens
<308> M19997
<400> 5886

gcgtcagcc  tgttgtcag  gtggccgtg  aggccaaga  cccggctga  ctgcccaag  60
tggtggagg  gctgaagcg  ctggccaag  ccgacccca  ggtgcagtg  atcatcgag  120
agtcgggag  gcatatcat  gcgggcgcc  gcgagctgc  cctggagat  tgcctgaag  180
acctggagg  ggaccacgc  tgcatcccc  tcaagaaat  tgacccggt  gtctcgtac  240
gcgagacgg  cagtgaaga  tcgaacgtg  tctgcctct  caagtcccc  aacaagcac  300
accggctgt  catgaaggc  cggcccttc  ccgacggcc  ggccgagga  atcgataaa  360
gcgaggtgt  cgcccgtca  gagctcaag  agcgggcgc  ctacctggc  gagaagtac  420
agtgggacg  ggctgaggc  cgcaagatc  ggtgctttg  gcccgacgg  accggcccc  480
acatcctca  cgacatcac  aagggtgtg  agtacctca  cgagatcaa  gacagtgtg  540
tggccggct  ccagtgggc  accaaggag  gcgcactgt  tgaggagaa  atgcggggt  600
tgcgcttcg  cgtccacga  gtcaccctg  acgccgacg  catccaccg  ggagggggc  660
agatcatcc  cacagcacg  cgctgcctc  atgccagtg  gctgaccgc  cagccacgc  720
tcatggagc  catctacct  gtggagatc  agtgtccag  gcaggtggt  ggtggcatc  780
acggggttt  gaacaggaa  cggggccac  tgttcgagg  gtcccaggt  gccggcacc  840
ccatgtttg  ggtcaaggc  tatctgccc  tcaacgagt  ctttggctt  accgctgac  900
tgaggtcca  cacgggcgg  caggcgttc  cccagtgtg  gtttgacca  tggcagatc  960
tgcccggag  ccccttcga  aacagcagc  gccccagcc  ggtggtggc  gagacccgc  1020
agcgcaagg  cctgaaaga  ggcatccct  ccctggaca  cttcctgga  aaattgtag  1080
cggcccttc  tgcagcgcc  gccgccccg  ggactcgca  cacccacag  accacgtcc  1140
cgaattctc  gacgacacc  ggagactgt  ccgacacag  gacgctccc  tgagaggtt  1200
ctggggccc  ctgcgtgcc  tcactcaac  ataacactt  atgccgttt  tttcaatat  1260
tatttccag  gtccggagg  agcagacac  ccctcttag  agggactta  tgggccggt  1320
ggggagggg  aggcgggat  ggacaccca  cactttttc  atttcttca  agggaaact  1380
agatgtcca  actaatttt  acaaacgca  taagaggtt  atttgggta  atggcccgc  1440
gtggctttt  ccccagaaa  gggaaagga  cacgcgggt  gatgatttc  agcaggcag  1500
aagtcctgt  cggtgtcac  atgagcact  agctgtact  gtgccattg  aataataaa  1560
ttgataagg  gtg  1573



<210> 5887
<211> 857
<212> PRT
<213> Homo sapiens
<308> P13639
<400> 5887

Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys Ala 
  1               5                  10                  15
Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys Ser 
             20                  25                  30
Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser Ala 
         35                  40                  45
Arg Ala Gly Glu Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln Glu 
     50                  55                  60
Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu Leu 
 65                  70                  75                  80
Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ala Gly 
                 85                  90                  95
Phe Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser Ser 
             100                105                110
Glu Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val Val 
         115                120                125
Asp Cys Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg Gln 
     130                135                140
Ala Ile Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met Asp 
 145                150                155                160
Arg Ala Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln Thr 
                 165                170                175
Phe Gln Arg Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr Gly 
             180                185                190
Glu Gly Glu Ser Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val Leu 
         195                200                205
Gly Thr Val Gly Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr Leu 
     210                215                220
Lys Gln Phe Ala Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly Glu 
 225                230                235                240
Gly Gln Leu Gly Pro Ala Glu Arg Ala Lys Lys Val Glu Asp Met Met 
                 245                250                255
Lys Lys Leu Trp Gly Asp Arg Tyr Phe Asp Pro Ala Asn Gly Lys Phe 
             260                265                270
Ser Lys Ser Ala Thr Ser Pro Glu Gly Lys Lys Leu Pro Arg Thr Phe 
         275                280                285
Cys Gln Leu Ile Leu Asp Pro Ile Phe Lys Val Phe Asp Ala Ile Met 
     290                295                300
Asn Phe Lys Lys Glu Glu Thr Ala Lys Leu Ile Glu Lys Leu Asp Ile 
 305                310                315                320
Lys Leu Asp Ser Glu Asp Lys Asp Lys Glu Gly Lys Pro Leu Leu Lys 
                 325                330                335
Ala Val Met Arg Arg Trp Leu Pro Ala Gly Asp Ala Leu Leu Gln Met 
             340                345                350
Ile Thr Ile His Leu Pro Ser Pro Val Thr Ala Gln Lys Tyr Arg Cys 
         355                360                365
Glu Leu Leu Tyr Glu Gly Pro Pro Asp Asp Glu Ala Ala Met Gly Ile 
     370                375                380
Lys Ser Cys Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys Met 
 385                390                395                400
Val Pro Thr Ser Asp Lys Gly Arg Phe Tyr Ala Phe Gly Arg Val Phe 
                 405                410                415
Ser Gly Leu Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro Asn 
             420                425                430
Tyr Thr Pro Gly Lys Lys Glu Asp Leu Tyr Leu Lys Pro Ile Gln Arg 
         435                440                445
Thr Ile Leu Met Met Gly Arg Tyr Val Glu Pro Ile Glu Asp Val Pro 
     450                455                460
Cys Gly Asn Ile Val Gly Leu Val Gly Val Asp Gln Phe Leu Val Lys 
 465                470                475                480
Thr Gly Thr Ile Thr Thr Phe Glu His Ala His Asn Met Arg Val Met 
                 485                490                495
Lys Phe Ser Val Ser Pro Val Val Arg Val Ala Val Glu Ala Lys Asn 
             500                505                510
Pro Ala Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg Leu Ala Lys 
         515                520                525
Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly Glu His Ile 
     530                535                540
Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu Lys Asp Leu 
 545                550                555                560
Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp Pro Val Val 
                 565                570                575
Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu Cys Leu Ser 
             580                585                590
Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala Arg Pro Phe 
         595                600                605
Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val Ser Ala Arg 
     610                615                620
Gln Glu Leu Lys Gln Arg Ala Arg Tyr Leu Ala Glu Lys Tyr Glu Trp 
 625                630                635                640
Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro Asp Gly Thr 
                 645                650                655
Gly Pro Asn Ile Leu Thr Asp Ile Thr Lys Gly Val Gln Tyr Leu Asn 
             660                665                670
Glu Ile Lys Asp Ser Val Val Ala Gly Phe Gln Trp Ala Thr Lys Glu 
         675                680                685
Gly Ala Leu Cys Glu Glu Asn Met Arg Gly Val Arg Phe Asp Val His 
     690                695                700
Asp Val Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln Ile 
 705                710                715                720
Ile Pro Thr Ala Arg Arg Cys Leu Tyr Ala Ser Val Leu Thr Ala Gln 
                 725                730                735
Pro Arg Leu Met Glu Pro Ile Tyr Leu Val Glu Ile Gln Cys Pro Glu 
             740                745                750
Gln Val Val Gly Gly Ile Tyr Gly Val Leu Asn Arg Lys Arg Gly His 
         755                760                765
Val Phe Glu Glu Ser Gln Val Ala Gly Thr Pro Met Phe Val Val Lys 
     770                775                780
Ala Tyr Leu Pro Val Asn Glu Ser Phe Gly Phe Thr Ala Asp Leu Arg 
 785                790                795                800
Ser Asn Thr Gly Gly Gln Ala Phe Pro Gln Cys Val Phe Asp His Trp 
                 805                810                815
Gln Ile Leu Pro Gly Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser Gln 
             820                825                830
Val Val Ala Glu Thr Arg Lys Arg Lys Gly Leu Lys Glu Gly Ile Pro 
         835                840                845
Ala Leu Asp Asn Phe Leu Asp Lys Leu 
     850                855



<210> 5888
<211> 528
<212> DNA
<213> Rattus norvegicus
<308> AA892801
<400> 5888

caaccacag  agagtttat  actccaatg  ttcgcacag  tgggttgca  gtctaaggg  60
tgcctgcct  cctggaggc  ctcccccac  tccccctct  ggggaatta  acttggcca  120
atacatctc  gcaaactgc  tcagtgtga  ggcccaccc  tgcaggcca  agccaaagc  180
tacagtgcc  aggacagga  cgatcatga  attgcccat  ggtccactc  cgccctcgc  240
ataggtgga  atgatgaca  tgacgttct  cacgatgcg  tggaaggtc  ggtagagct  300
ctcaggctc  agttgcagt  ccagcaggg  ccggtccat  ttgttcatc  tcagcacgg  360
cttgatgcg  tcagcgatg  cctgccgca  cactgtctc  gtctgcaca  agacaccag  420
cacacagtc  accaccacc  gtgctccat  agtgacacg  agagcagcg  tcacctctg  480
ggagaagtc  acatgacct  gagagtcaa  gaggttgat  ctcgtgcc  528



<210> 5889
<211> 857
<212> PRT
<213> Rattus norvegicus
<308> P05197
<400> 5889

Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys Ala 
  1               5                  10                  15
Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys Ser 
             20                  25                  30
Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser Ala 
         35                  40                  45
Arg Ala Gly Glu Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln Glu 
     50                  55                  60
Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu Leu 
 65                  70                  75                  80
Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ser Gly 
                 85                  90                  95
Phe Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser Ser 
             100                105                110
Glu Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val Val 
         115                120                125
Asp Cys Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg Gln 
     130                135                140
Ala Ile Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met Asp 
 145                150                155                160
Arg Ala Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln Thr 
                 165                170                175
Phe Gln Arg Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr Gly 
             180                185                190
Glu Gly Glu Ser Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val Leu 
         195                200                205
Gly Thr Val Gly Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr Leu 
     210                215                220
Lys Gln Phe Ala Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly Glu 
 225                230                235                240
Gly Gln Leu Gly Ala Ala Glu Arg Ala Lys Lys Val Glu Asp Met Met 
                 245                250                255
Lys Lys Leu Trp Gly Asp Arg Tyr Phe Asp Pro Ala Asn Gly Lys Phe 
             260                265                270
Ser Lys Ser Ala Asn Ser Pro Asp Gly Lys Lys Leu Pro Arg Thr Phe 
         275                280                285
Cys Gln Leu Ile Leu Asp Pro Ile Phe Lys Val Phe Asp Ala Ile Met 
     290                295                300
Asn Phe Arg Lys Glu Glu Thr Ala Lys Leu Ile Glu Lys Leu Asp Ile 
 305                310                315                320
Lys Leu Asp Ser Glu Asp Lys Asp Lys Glu Gly Lys Pro Leu Leu Lys 
                 325                330                335
Ala Val Met Arg Arg Trp Leu Pro Ala Gly Asp Ala Leu Leu Gln Met 
             340                345                350
Ile Thr Ile His Leu Pro Ser Pro Val Thr Ala Gln Lys Tyr Arg Cys 
         355                360                365
Glu Leu Leu Tyr Glu Gly Pro Pro Asp Asp Glu Ala Ala Met Gly Ile 
     370                375                380
Lys Ser Cys Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys Met 
 385                390                395                400
Val Pro Thr Ser Asp Lys Gly Arg Phe Tyr Ala Phe Gly Arg Val Phe 
                 405                410                415
Ser Gly Val Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro Asn 
             420                425                430
Tyr Thr Pro Gly Lys Lys Glu Asp Leu Tyr Leu Lys Pro Ile Gln Arg 
         435                440                445
Thr Ile Leu Met Met Gly Arg Tyr Val Glu Pro Ile Glu Asp Val Pro 
     450                455                460
Cys Gly Asn Ile Val Gly Leu Val Gly Val Asp Gln Phe Leu Val Lys 
 465                470                475                480
Thr Gly Thr Ile Thr Thr Phe Glu His Ala His Asn Met Arg Val Met 
                 485                490                495
Lys Phe Ser Val Ser Pro Val Val Arg Val Ala Val Glu Ala Lys Asn 
             500                505                510
Pro Ala Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg Leu Ala Lys 
         515                520                525
Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly Glu His Ile 
     530                535                540
Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu Lys Asp Leu 
 545                550                555                560
Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp Pro Val Val 
                 565                570                575
Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu Cys Leu Ser 
             580                585                590
Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala Arg Pro Phe 
         595                600                605
Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val Ser Ala Arg 
     610                615                620
Gln Glu Leu Lys Ala Arg Ala Arg Tyr Leu Ala Glu Lys Tyr Glu Trp 
 625                630                635                640
Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro Asp Gly Thr 
                 645                650                655
Gly Pro Asn Ile Leu Thr Asp Ile Thr Lys Gly Val Gln Tyr Leu Asn 
             660                665                670
Glu Ile Lys Asp Ser Val Val Ala Gly Phe Gln Trp Ala Thr Lys Glu 
         675                680                685
Gly Ala Leu Cys Glu Glu Asn Met Arg Gly Val Arg Phe Asp Val His 
     690                695                700
Asp Val Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln Ile 
 705                710                715                720
Ile Pro Thr Ala Arg Arg Cys Leu Tyr Ala Ser Val Leu Thr Ala Gln 
                 725                730                735
Pro Arg Leu Met Glu Pro Ile Tyr Leu Val Glu Ile Gln Cys Pro Glu 
             740                745                750
Gln Val Val Gly Gly Ile Tyr Gly Val Leu Asn Arg Lys Arg Gly His 
         755                760                765
Val Phe Glu Glu Ser Gln Val Ala Gly Thr Pro Met Phe Val Val Lys 
     770                775                780
Ala Tyr Leu Pro Val Asn Glu Ser Phe Gly Phe Thr Ala Asp Leu Arg 
 785                790                795                800
Ser Asn Thr Gly Gly Gln Ala Phe Pro Gln Cys Val Phe Asp His Trp 
                 805                810                815
Gln Ile Leu Pro Gly Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser Gln 
             820                825                830
Val Val Ala Glu Thr Arg Lys Arg Lys Gly Leu Lys Glu Gly Ile Pro 
         835                840                845
Ala Leu Asp Asn Phe Leu Asp Lys Leu 
     850                855



<210> 5890
<211> 1573
<212> DNA
<213> Homo sapiens
<308> M19997
<400> 5890

gcgtcagcc  tgttgtcag  gtggccgtg  aggccaaga  cccggctga  ctgcccaag  60
tggtggagg  gctgaagcg  ctggccaag  ccgacccca  ggtgcagtg  atcatcgag  120
agtcgggag  gcatatcat  gcgggcgcc  gcgagctgc  cctggagat  tgcctgaag  180
acctggagg  ggaccacgc  tgcatcccc  tcaagaaat  tgacccggt  gtctcgtac  240
gcgagacgg  cagtgaaga  tcgaacgtg  tctgcctct  caagtcccc  aacaagcac  300
accggctgt  catgaaggc  cggcccttc  ccgacggcc  ggccgagga  atcgataaa  360
gcgaggtgt  cgcccgtca  gagctcaag  agcgggcgc  ctacctggc  gagaagtac  420
agtgggacg  ggctgaggc  cgcaagatc  ggtgctttg  gcccgacgg  accggcccc  480
acatcctca  cgacatcac  aagggtgtg  agtacctca  cgagatcaa  gacagtgtg  540
tggccggct  ccagtgggc  accaaggag  gcgcactgt  tgaggagaa  atgcggggt  600
tgcgcttcg  cgtccacga  gtcaccctg  acgccgacg  catccaccg  ggagggggc  660
agatcatcc  cacagcacg  cgctgcctc  atgccagtg  gctgaccgc  cagccacgc  720
tcatggagc  catctacct  gtggagatc  agtgtccag  gcaggtggt  ggtggcatc  780
acggggttt  gaacaggaa  cggggccac  tgttcgagg  gtcccaggt  gccggcacc  840
ccatgtttg  ggtcaaggc  tatctgccc  tcaacgagt  ctttggctt  accgctgac  900
tgaggtcca  cacgggcgg  caggcgttc  cccagtgtg  gtttgacca  tggcagatc  960
tgcccggag  ccccttcga  aacagcagc  gccccagcc  ggtggtggc  gagacccgc  1020
agcgcaagg  cctgaaaga  ggcatccct  ccctggaca  cttcctgga  aaattgtag  1080
cggcccttc  tgcagcgcc  gccgccccg  ggactcgca  cacccacag  accacgtcc  1140
cgaattctc  gacgacacc  ggagactgt  ccgacacag  gacgctccc  tgagaggtt  1200
ctggggccc  ctgcgtgcc  tcactcaac  ataacactt  atgccgttt  tttcaatat  1260
tatttccag  gtccggagg  agcagacac  ccctcttag  agggactta  tgggccggt  1320
ggggagggg  aggcgggat  ggacaccca  cactttttc  atttcttca  agggaaact  1380
agatgtcca  actaatttt  acaaacgca  taagaggtt  atttgggta  atggcccgc  1440
gtggctttt  ccccagaaa  gggaaagga  cacgcgggt  gatgatttc  agcaggcag  1500
aagtcctgt  cggtgtcac  atgagcact  agctgtact  gtgccattg  aataataaa  1560
ttgataagg  gtg  1573



<210> 5891
<211> 857
<212> PRT
<213> Homo sapiens
<308> P13639
<400> 5891

Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys Ala 
  1               5                  10                  15
Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys Ser 
             20                  25                  30
Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser Ala 
         35                  40                  45
Arg Ala Gly Glu Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln Glu 
     50                  55                  60
Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu Leu 
 65                  70                  75                  80
Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ala Gly 
                 85                  90                  95
Phe Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser Ser 
             100                105                110
Glu Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val Val 
         115                120                125
Asp Cys Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg Gln 
     130                135                140
Ala Ile Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met Asp 
 145                150                155                160
Arg Ala Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln Thr 
                 165                170                175
Phe Gln Arg Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr Gly 
             180                185                190
Glu Gly Glu Ser Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val Leu 
         195                200                205
Gly Thr Val Gly Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr Leu 
     210                215                220
Lys Gln Phe Ala Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly Glu 
 225                230                235                240
Gly Gln Leu Gly Pro Ala Glu Arg Ala Lys Lys Val Glu Asp Met Met 
                 245                250                255
Lys Lys Leu Trp Gly Asp Arg Tyr Phe Asp Pro Ala Asn Gly Lys Phe 
             260                265                270
Ser Lys Ser Ala Thr Ser Pro Glu Gly Lys Lys Leu Pro Arg Thr Phe 
         275                280                285
Cys Gln Leu Ile Leu Asp Pro Ile Phe Lys Val Phe Asp Ala Ile Met 
     290                295                300
Asn Phe Lys Lys Glu Glu Thr Ala Lys Leu Ile Glu Lys Leu Asp Ile 
 305                310                315                320
Lys Leu Asp Ser Glu Asp Lys Asp Lys Glu Gly Lys Pro Leu Leu Lys 
                 325                330                335
Ala Val Met Arg Arg Trp Leu Pro Ala Gly Asp Ala Leu Leu Gln Met 
             340                345                350
Ile Thr Ile His Leu Pro Ser Pro Val Thr Ala Gln Lys Tyr Arg Cys 
         355                360                365
Glu Leu Leu Tyr Glu Gly Pro Pro Asp Asp Glu Ala Ala Met Gly Ile 
     370                375                380
Lys Ser Cys Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys Met 
 385                390                395                400
Val Pro Thr Ser Asp Lys Gly Arg Phe Tyr Ala Phe Gly Arg Val Phe 
                 405                410                415
Ser Gly Leu Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro Asn 
             420                425                430
Tyr Thr Pro Gly Lys Lys Glu Asp Leu Tyr Leu Lys Pro Ile Gln Arg 
         435                440                445
Thr Ile Leu Met Met Gly Arg Tyr Val Glu Pro Ile Glu Asp Val Pro 
     450                455                460
Cys Gly Asn Ile Val Gly Leu Val Gly Val Asp Gln Phe Leu Val Lys 
 465                470                475                480
Thr Gly Thr Ile Thr Thr Phe Glu His Ala His Asn Met Arg Val Met 
                 485                490                495
Lys Phe Ser Val Ser Pro Val Val Arg Val Ala Val Glu Ala Lys Asn 
             500                505                510
Pro Ala Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg Leu Ala Lys 
         515                520                525
Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly Glu His Ile 
     530                535                540
Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu Lys Asp Leu 
 545                550                555                560
Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp Pro Val Val 
                 565                570                575
Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu Cys Leu Ser 
             580                585                590
Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala Arg Pro Phe 
         595                600                605
Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val Ser Ala Arg 
     610                615                620
Gln Glu Leu Lys Gln Arg Ala Arg Tyr Leu Ala Glu Lys Tyr Glu Trp 
 625                630                635                640
Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro Asp Gly Thr 
                 645                650                655
Gly Pro Asn Ile Leu Thr Asp Ile Thr Lys Gly Val Gln Tyr Leu Asn 
             660                665                670
Glu Ile Lys Asp Ser Val Val Ala Gly Phe Gln Trp Ala Thr Lys Glu 
         675                680                685
Gly Ala Leu Cys Glu Glu Asn Met Arg Gly Val Arg Phe Asp Val His 
     690                695                700
Asp Val Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln Ile 
 705                710                715                720
Ile Pro Thr Ala Arg Arg Cys Leu Tyr Ala Ser Val Leu Thr Ala Gln 
                 725                730                735
Pro Arg Leu Met Glu Pro Ile Tyr Leu Val Glu Ile Gln Cys Pro Glu 
             740                745                750
Gln Val Val Gly Gly Ile Tyr Gly Val Leu Asn Arg Lys Arg Gly His 
         755                760                765
Val Phe Glu Glu Ser Gln Val Ala Gly Thr Pro Met Phe Val Val Lys 
     770                775                780
Ala Tyr Leu Pro Val Asn Glu Ser Phe Gly Phe Thr Ala Asp Leu Arg 
 785                790                795                800
Ser Asn Thr Gly Gly Gln Ala Phe Pro Gln Cys Val Phe Asp His Trp 
                 805                810                815
Gln Ile Leu Pro Gly Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser Gln 
             820                825                830
Val Val Ala Glu Thr Arg Lys Arg Lys Gly Leu Lys Glu Gly Ile Pro 
         835                840                845
Ala Leu Asp Asn Phe Leu Asp Lys Leu 
     850                855



<210> 5892
<211> 528
<212> DNA
<213> Rattus norvegicus
<308> AA892801
<400> 5892

caaccacag  agagtttat  actccaatg  ttcgcacag  tgggttgca  gtctaaggg  60
tgcctgcct  cctggaggc  ctcccccac  tccccctct  ggggaatta  acttggcca  120
atacatctc  gcaaactgc  tcagtgtga  ggcccaccc  tgcaggcca  agccaaagc  180
tacagtgcc  aggacagga  cgatcatga  attgcccat  ggtccactc  cgccctcgc  240
ataggtgga  atgatgaca  tgacgttct  cacgatgcg  tggaaggtc  ggtagagct  300
ctcaggctc  agttgcagt  ccagcaggg  ccggtccat  ttgttcatc  tcagcacgg  360
cttgatgcg  tcagcgatg  cctgccgca  cactgtctc  gtctgcaca  agacaccag  420
cacacagtc  accaccacc  gtgctccat  agtgacacg  agagcagcg  tcacctctg  480
ggagaagtc  acatgacct  gagagtcaa  gaggttgat  ctcgtgcc  528



<210> 5893
<211> 857
<212> PRT
<213> Rattus norvegicus
<308> P05197
<400> 5893

Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys Ala 
  1               5                  10                  15
Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys Ser 
             20                  25                  30
Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser Ala 
         35                  40                  45
Arg Ala Gly Glu Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln Glu 
     50                  55                  60
Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu Leu 
 65                  70                  75                  80
Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ser Gly 
                 85                  90                  95
Phe Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser Ser 
             100                105                110
Glu Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val Val 
         115                120                125
Asp Cys Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg Gln 
     130                135                140
Ala Ile Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met Asp 
 145                150                155                160
Arg Ala Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln Thr 
                 165                170                175
Phe Gln Arg Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr Gly 
             180                185                190
Glu Gly Glu Ser Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val Leu 
         195                200                205
Gly Thr Val Gly Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr Leu 
     210                215                220
Lys Gln Phe Ala Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly Glu 
 225                230                235                240
Gly Gln Leu Gly Ala Ala Glu Arg Ala Lys Lys Val Glu Asp Met Met 
                 245                250                255
Lys Lys Leu Trp Gly Asp Arg Tyr Phe Asp Pro Ala Asn Gly Lys Phe 
             260                265                270
Ser Lys Ser Ala Asn Ser Pro Asp Gly Lys Lys Leu Pro Arg Thr Phe 
         275                280                285
Cys Gln Leu Ile Leu Asp Pro Ile Phe Lys Val Phe Asp Ala Ile Met 
     290                295                300
Asn Phe Arg Lys Glu Glu Thr Ala Lys Leu Ile Glu Lys Leu Asp Ile 
 305                310                315                320
Lys Leu Asp Ser Glu Asp Lys Asp Lys Glu Gly Lys Pro Leu Leu Lys 
                 325                330                335
Ala Val Met Arg Arg Trp Leu Pro Ala Gly Asp Ala Leu Leu Gln Met 
             340                345                350
Ile Thr Ile His Leu Pro Ser Pro Val Thr Ala Gln Lys Tyr Arg Cys 
         355                360                365
Glu Leu Leu Tyr Glu Gly Pro Pro Asp Asp Glu Ala Ala Met Gly Ile 
     370                375                380
Lys Ser Cys Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys Met 
 385                390                395                400
Val Pro Thr Ser Asp Lys Gly Arg Phe Tyr Ala Phe Gly Arg Val Phe 
                 405                410                415
Ser Gly Val Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro Asn 
             420                425                430
Tyr Thr Pro Gly Lys Lys Glu Asp Leu Tyr Leu Lys Pro Ile Gln Arg 
         435                440                445
Thr Ile Leu Met Met Gly Arg Tyr Val Glu Pro Ile Glu Asp Val Pro 
     450                455                460
Cys Gly Asn Ile Val Gly Leu Val Gly Val Asp Gln Phe Leu Val Lys 
 465                470                475                480
Thr Gly Thr Ile Thr Thr Phe Glu His Ala His Asn Met Arg Val Met 
                 485                490                495
Lys Phe Ser Val Ser Pro Val Val Arg Val Ala Val Glu Ala Lys Asn 
             500                505                510
Pro Ala Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg Leu Ala Lys 
         515                520                525
Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly Glu His Ile 
     530                535                540
Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu Lys Asp Leu 
 545                550                555                560
Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp Pro Val Val 
                 565                570                575
Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu Cys Leu Ser 
             580                585                590
Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala Arg Pro Phe 
         595                600                605
Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val Ser Ala Arg 
     610                615                620
Gln Glu Leu Lys Ala Arg Ala Arg Tyr Leu Ala Glu Lys Tyr Glu Trp 
 625                630                635                640
Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro Asp Gly Thr 
                 645                650                655
Gly Pro Asn Ile Leu Thr Asp Ile Thr Lys Gly Val Gln Tyr Leu Asn 
             660                665                670
Glu Ile Lys Asp Ser Val Val Ala Gly Phe Gln Trp Ala Thr Lys Glu 
         675                680                685
Gly Ala Leu Cys Glu Glu Asn Met Arg Gly Val Arg Phe Asp Val His 
     690                695                700
Asp Val Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln Ile 
 705                710                715                720
Ile Pro Thr Ala Arg Arg Cys Leu Tyr Ala Ser Val Leu Thr Ala Gln 
                 725                730                735
Pro Arg Leu Met Glu Pro Ile Tyr Leu Val Glu Ile Gln Cys Pro Glu 
             740                745                750
Gln Val Val Gly Gly Ile Tyr Gly Val Leu Asn Arg Lys Arg Gly His 
         755                760                765
Val Phe Glu Glu Ser Gln Val Ala Gly Thr Pro Met Phe Val Val Lys 
     770                775                780
Ala Tyr Leu Pro Val Asn Glu Ser Phe Gly Phe Thr Ala Asp Leu Arg 
 785                790                795                800
Ser Asn Thr Gly Gly Gln Ala Phe Pro Gln Cys Val Phe Asp His Trp 
                 805                810                815
Gln Ile Leu Pro Gly Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser Gln 
             820                825                830
Val Val Ala Glu Thr Arg Lys Arg Lys Gly Leu Lys Glu Gly Ile Pro 
         835                840                845
Ala Leu Asp Asn Phe Leu Asp Lys Leu 
     850                855



<210> 5894
<211> 1573
<212> DNA
<213> Homo sapiens
<308> M19997
<400> 5894

gcgtcagcc  tgttgtcag  gtggccgtg  aggccaaga  cccggctga  ctgcccaag  60
tggtggagg  gctgaagcg  ctggccaag  ccgacccca  ggtgcagtg  atcatcgag  120
agtcgggag  gcatatcat  gcgggcgcc  gcgagctgc  cctggagat  tgcctgaag  180
acctggagg  ggaccacgc  tgcatcccc  tcaagaaat  tgacccggt  gtctcgtac  240
gcgagacgg  cagtgaaga  tcgaacgtg  tctgcctct  caagtcccc  aacaagcac  300
accggctgt  catgaaggc  cggcccttc  ccgacggcc  ggccgagga  atcgataaa  360
gcgaggtgt  cgcccgtca  gagctcaag  agcgggcgc  ctacctggc  gagaagtac  420
agtgggacg  ggctgaggc  cgcaagatc  ggtgctttg  gcccgacgg  accggcccc  480
acatcctca  cgacatcac  aagggtgtg  agtacctca  cgagatcaa  gacagtgtg  540
tggccggct  ccagtgggc  accaaggag  gcgcactgt  tgaggagaa  atgcggggt  600
tgcgcttcg  cgtccacga  gtcaccctg  acgccgacg  catccaccg  ggagggggc  660
agatcatcc  cacagcacg  cgctgcctc  atgccagtg  gctgaccgc  cagccacgc  720
tcatggagc  catctacct  gtggagatc  agtgtccag  gcaggtggt  ggtggcatc  780
acggggttt  gaacaggaa  cggggccac  tgttcgagg  gtcccaggt  gccggcacc  840
ccatgtttg  ggtcaaggc  tatctgccc  tcaacgagt  ctttggctt  accgctgac  900
tgaggtcca  cacgggcgg  caggcgttc  cccagtgtg  gtttgacca  tggcagatc  960
tgcccggag  ccccttcga  aacagcagc  gccccagcc  ggtggtggc  gagacccgc  1020
agcgcaagg  cctgaaaga  ggcatccct  ccctggaca  cttcctgga  aaattgtag  1080
cggcccttc  tgcagcgcc  gccgccccg  ggactcgca  cacccacag  accacgtcc  1140
cgaattctc  gacgacacc  ggagactgt  ccgacacag  gacgctccc  tgagaggtt  1200
ctggggccc  ctgcgtgcc  tcactcaac  ataacactt  atgccgttt  tttcaatat  1260
tatttccag  gtccggagg  agcagacac  ccctcttag  agggactta  tgggccggt  1320
ggggagggg  aggcgggat  ggacaccca  cactttttc  atttcttca  agggaaact  1380
agatgtcca  actaatttt  acaaacgca  taagaggtt  atttgggta  atggcccgc  1440
gtggctttt  ccccagaaa  gggaaagga  cacgcgggt  gatgatttc  agcaggcag  1500
aagtcctgt  cggtgtcac  atgagcact  agctgtact  gtgccattg  aataataaa  1560
ttgataagg  gtg  1573



<210> 5895
<211> 857
<212> PRT
<213> Homo sapiens
<308> P13639
<400> 5895

Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys Ala 
  1               5                  10                  15
Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys Ser 
             20                  25                  30
Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser Ala 
         35                  40                  45
Arg Ala Gly Glu Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln Glu 
     50                  55                  60
Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu Leu 
 65                  70                  75                  80
Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ala Gly 
                 85                  90                  95
Phe Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser Ser 
             100                105                110
Glu Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val Val 
         115                120                125
Asp Cys Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg Gln 
     130                135                140
Ala Ile Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met Asp 
 145                150                155                160
Arg Ala Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln Thr 
                 165                170                175
Phe Gln Arg Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr Gly 
             180                185                190
Glu Gly Glu Ser Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val Leu 
         195                200                205
Gly Thr Val Gly Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr Leu 
     210                215                220
Lys Gln Phe Ala Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly Glu 
 225                230                235                240
Gly Gln Leu Gly Pro Ala Glu Arg Ala Lys Lys Val Glu Asp Met Met 
                 245                250                255
Lys Lys Leu Trp Gly Asp Arg Tyr Phe Asp Pro Ala Asn Gly Lys Phe 
             260                265                270
Ser Lys Ser Ala Thr Ser Pro Glu Gly Lys Lys Leu Pro Arg Thr Phe 
         275                280                285
Cys Gln Leu Ile Leu Asp Pro Ile Phe Lys Val Phe Asp Ala Ile Met 
     290                295                300
Asn Phe Lys Lys Glu Glu Thr Ala Lys Leu Ile Glu Lys Leu Asp Ile 
 305                310                315                320
Lys Leu Asp Ser Glu Asp Lys Asp Lys Glu Gly Lys Pro Leu Leu Lys 
                 325                330                335
Ala Val Met Arg Arg Trp Leu Pro Ala Gly Asp Ala Leu Leu Gln Met 
             340                345                350
Ile Thr Ile His Leu Pro Ser Pro Val Thr Ala Gln Lys Tyr Arg Cys 
         355                360                365
Glu Leu Leu Tyr Glu Gly Pro Pro Asp Asp Glu Ala Ala Met Gly Ile 
     370                375                380
Lys Ser Cys Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys Met 
 385                390                395                400
Val Pro Thr Ser Asp Lys Gly Arg Phe Tyr Ala Phe Gly Arg Val Phe 
                 405                410                415
Ser Gly Leu Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro Asn 
             420                425                430
Tyr Thr Pro Gly Lys Lys Glu Asp Leu Tyr Leu Lys Pro Ile Gln Arg 
         435                440                445
Thr Ile Leu Met Met Gly Arg Tyr Val Glu Pro Ile Glu Asp Val Pro 
     450                455                460
Cys Gly Asn Ile Val Gly Leu Val Gly Val Asp Gln Phe Leu Val Lys 
 465                470                475                480
Thr Gly Thr Ile Thr Thr Phe Glu His Ala His Asn Met Arg Val Met 
                 485                490                495
Lys Phe Ser Val Ser Pro Val Val Arg Val Ala Val Glu Ala Lys Asn 
             500                505                510
Pro Ala Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg Leu Ala Lys 
         515                520                525
Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly Glu His Ile 
     530                535                540
Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu Lys Asp Leu 
 545                550                555                560
Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp Pro Val Val 
                 565                570                575
Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu Cys Leu Ser 
             580                585                590
Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala Arg Pro Phe 
         595                600                605
Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val Ser Ala Arg 
     610                615                620
Gln Glu Leu Lys Gln Arg Ala Arg Tyr Leu Ala Glu Lys Tyr Glu Trp 
 625                630                635                640
Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro Asp Gly Thr 
                 645                650                655
Gly Pro Asn Ile Leu Thr Asp Ile Thr Lys Gly Val Gln Tyr Leu Asn 
             660                665                670
Glu Ile Lys Asp Ser Val Val Ala Gly Phe Gln Trp Ala Thr Lys Glu 
         675                680                685
Gly Ala Leu Cys Glu Glu Asn Met Arg Gly Val Arg Phe Asp Val His 
     690                695                700
Asp Val Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln Ile 
 705                710                715                720
Ile Pro Thr Ala Arg Arg Cys Leu Tyr Ala Ser Val Leu Thr Ala Gln 
                 725                730                735
Pro Arg Leu Met Glu Pro Ile Tyr Leu Val Glu Ile Gln Cys Pro Glu 
             740                745                750
Gln Val Val Gly Gly Ile Tyr Gly Val Leu Asn Arg Lys Arg Gly His 
         755                760                765
Val Phe Glu Glu Ser Gln Val Ala Gly Thr Pro Met Phe Val Val Lys 
     770                775                780
Ala Tyr Leu Pro Val Asn Glu Ser Phe Gly Phe Thr Ala Asp Leu Arg 
 785                790                795                800
Ser Asn Thr Gly Gly Gln Ala Phe Pro Gln Cys Val Phe Asp His Trp 
                 805                810                815
Gln Ile Leu Pro Gly Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser Gln 
             820                825                830
Val Val Ala Glu Thr Arg Lys Arg Lys Gly Leu Lys Glu Gly Ile Pro 
         835                840                845
Ala Leu Asp Asn Phe Leu Asp Lys Leu 
     850                855



<210> 5896
<211> 528
<212> DNA
<213> Rattus norvegicus
<308> AA892801
<400> 5896

caaccacag  agagtttat  actccaatg  ttcgcacag  tgggttgca  gtctaaggg  60
tgcctgcct  cctggaggc  ctcccccac  tccccctct  ggggaatta  acttggcca  120
atacatctc  gcaaactgc  tcagtgtga  ggcccaccc  tgcaggcca  agccaaagc  180
tacagtgcc  aggacagga  cgatcatga  attgcccat  ggtccactc  cgccctcgc  240
ataggtgga  atgatgaca  tgacgttct  cacgatgcg  tggaaggtc  ggtagagct  300
ctcaggctc  agttgcagt  ccagcaggg  ccggtccat  ttgttcatc  tcagcacgg  360
cttgatgcg  tcagcgatg  cctgccgca  cactgtctc  gtctgcaca  agacaccag  420
cacacagtc  accaccacc  gtgctccat  agtgacacg  agagcagcg  tcacctctg  480
ggagaagtc  acatgacct  gagagtcaa  gaggttgat  ctcgtgcc  528



<210> 5897
<211> 857
<212> PRT
<213> Rattus norvegicus
<308> P05197
<400> 5897

Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys Ala 
  1               5                  10                  15
Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys Ser 
             20                  25                  30
Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser Ala 
         35                  40                  45
Arg Ala Gly Glu Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln Glu 
     50                  55                  60
Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu Leu 
 65                  70                  75                  80
Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ser Gly 
                 85                  90                  95
Phe Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser Ser 
             100                105                110
Glu Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val Val 
         115                120                125
Asp Cys Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg Gln 
     130                135                140
Ala Ile Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met Asp 
 145                150                155                160
Arg Ala Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln Thr 
                 165                170                175
Phe Gln Arg Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr Gly 
             180                185                190
Glu Gly Glu Ser Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val Leu 
         195                200                205
Gly Thr Val Gly Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr Leu 
     210                215                220
Lys Gln Phe Ala Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly Glu 
 225                230                235                240
Gly Gln Leu Gly Ala Ala Glu Arg Ala Lys Lys Val Glu Asp Met Met 
                 245                250                255
Lys Lys Leu Trp Gly Asp Arg Tyr Phe Asp Pro Ala Asn Gly Lys Phe 
             260                265                270
Ser Lys Ser Ala Asn Ser Pro Asp Gly Lys Lys Leu Pro Arg Thr Phe 
         275                280                285
Cys Gln Leu Ile Leu Asp Pro Ile Phe Lys Val Phe Asp Ala Ile Met 
     290                295                300
Asn Phe Arg Lys Glu Glu Thr Ala Lys Leu Ile Glu Lys Leu Asp Ile 
 305                310                315                320
Lys Leu Asp Ser Glu Asp Lys Asp Lys Glu Gly Lys Pro Leu Leu Lys 
                 325                330                335
Ala Val Met Arg Arg Trp Leu Pro Ala Gly Asp Ala Leu Leu Gln Met 
             340                345                350
Ile Thr Ile His Leu Pro Ser Pro Val Thr Ala Gln Lys Tyr Arg Cys 
         355                360                365
Glu Leu Leu Tyr Glu Gly Pro Pro Asp Asp Glu Ala Ala Met Gly Ile 
     370                375                380
Lys Ser Cys Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys Met 
 385                390                395                400
Val Pro Thr Ser Asp Lys Gly Arg Phe Tyr Ala Phe Gly Arg Val Phe 
                 405                410                415
Ser Gly Val Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro Asn 
             420                425                430
Tyr Thr Pro Gly Lys Lys Glu Asp Leu Tyr Leu Lys Pro Ile Gln Arg 
         435                440                445
Thr Ile Leu Met Met Gly Arg Tyr Val Glu Pro Ile Glu Asp Val Pro 
     450                455                460
Cys Gly Asn Ile Val Gly Leu Val Gly Val Asp Gln Phe Leu Val Lys 
 465                470                475                480
Thr Gly Thr Ile Thr Thr Phe Glu His Ala His Asn Met Arg Val Met 
                 485                490                495
Lys Phe Ser Val Ser Pro Val Val Arg Val Ala Val Glu Ala Lys Asn 
             500                505                510
Pro Ala Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg Leu Ala Lys 
         515                520                525
Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly Glu His Ile 
     530                535                540
Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu Lys Asp Leu 
 545                550                555                560
Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp Pro Val Val 
                 565                570                575
Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu Cys Leu Ser 
             580                585                590
Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala Arg Pro Phe 
         595                600                605
Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val Ser Ala Arg 
     610                615                620
Gln Glu Leu Lys Ala Arg Ala Arg Tyr Leu Ala Glu Lys Tyr Glu Trp 
 625                630                635                640
Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro Asp Gly Thr 
                 645                650                655
Gly Pro Asn Ile Leu Thr Asp Ile Thr Lys Gly Val Gln Tyr Leu Asn 
             660                665                670
Glu Ile Lys Asp Ser Val Val Ala Gly Phe Gln Trp Ala Thr Lys Glu 
         675                680                685
Gly Ala Leu Cys Glu Glu Asn Met Arg Gly Val Arg Phe Asp Val His 
     690                695                700
Asp Val Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln Ile 
 705                710                715                720
Ile Pro Thr Ala Arg Arg Cys Leu Tyr Ala Ser Val Leu Thr Ala Gln 
                 725                730                735
Pro Arg Leu Met Glu Pro Ile Tyr Leu Val Glu Ile Gln Cys Pro Glu 
             740                745                750
Gln Val Val Gly Gly Ile Tyr Gly Val Leu Asn Arg Lys Arg Gly His 
         755                760                765
Val Phe Glu Glu Ser Gln Val Ala Gly Thr Pro Met Phe Val Val Lys 
     770                775                780
Ala Tyr Leu Pro Val Asn Glu Ser Phe Gly Phe Thr Ala Asp Leu Arg 
 785                790                795                800
Ser Asn Thr Gly Gly Gln Ala Phe Pro Gln Cys Val Phe Asp His Trp 
                 805                810                815
Gln Ile Leu Pro Gly Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser Gln 
             820                825                830
Val Val Ala Glu Thr Arg Lys Arg Lys Gly Leu Lys Glu Gly Ile Pro 
         835                840                845
Ala Leu Asp Asn Phe Leu Asp Lys Leu 
     850                855



<210> 5898
<211> 1573
<212> DNA
<213> Homo sapiens
<308> M19997
<400> 5898

gcgtcagcc  tgttgtcag  gtggccgtg  aggccaaga  cccggctga  ctgcccaag  60
tggtggagg  gctgaagcg  ctggccaag  ccgacccca  ggtgcagtg  atcatcgag  120
agtcgggag  gcatatcat  gcgggcgcc  gcgagctgc  cctggagat  tgcctgaag  180
acctggagg  ggaccacgc  tgcatcccc  tcaagaaat  tgacccggt  gtctcgtac  240
gcgagacgg  cagtgaaga  tcgaacgtg  tctgcctct  caagtcccc  aacaagcac  300
accggctgt  catgaaggc  cggcccttc  ccgacggcc  ggccgagga  atcgataaa  360
gcgaggtgt  cgcccgtca  gagctcaag  agcgggcgc  ctacctggc  gagaagtac  420
agtgggacg  ggctgaggc  cgcaagatc  ggtgctttg  gcccgacgg  accggcccc  480
acatcctca  cgacatcac  aagggtgtg  agtacctca  cgagatcaa  gacagtgtg  540
tggccggct  ccagtgggc  accaaggag  gcgcactgt  tgaggagaa  atgcggggt  600
tgcgcttcg  cgtccacga  gtcaccctg  acgccgacg  catccaccg  ggagggggc  660
agatcatcc  cacagcacg  cgctgcctc  atgccagtg  gctgaccgc  cagccacgc  720
tcatggagc  catctacct  gtggagatc  agtgtccag  gcaggtggt  ggtggcatc  780
acggggttt  gaacaggaa  cggggccac  tgttcgagg  gtcccaggt  gccggcacc  840
ccatgtttg  ggtcaaggc  tatctgccc  tcaacgagt  ctttggctt  accgctgac  900
tgaggtcca  cacgggcgg  caggcgttc  cccagtgtg  gtttgacca  tggcagatc  960
tgcccggag  ccccttcga  aacagcagc  gccccagcc  ggtggtggc  gagacccgc  1020
agcgcaagg  cctgaaaga  ggcatccct  ccctggaca  cttcctgga  aaattgtag  1080
cggcccttc  tgcagcgcc  gccgccccg  ggactcgca  cacccacag  accacgtcc  1140
cgaattctc  gacgacacc  ggagactgt  ccgacacag  gacgctccc  tgagaggtt  1200
ctggggccc  ctgcgtgcc  tcactcaac  ataacactt  atgccgttt  tttcaatat  1260
tatttccag  gtccggagg  agcagacac  ccctcttag  agggactta  tgggccggt  1320
ggggagggg  aggcgggat  ggacaccca  cactttttc  atttcttca  agggaaact  1380
agatgtcca  actaatttt  acaaacgca  taagaggtt  atttgggta  atggcccgc  1440
gtggctttt  ccccagaaa  gggaaagga  cacgcgggt  gatgatttc  agcaggcag  1500
aagtcctgt  cggtgtcac  atgagcact  agctgtact  gtgccattg  aataataaa  1560
ttgataagg  gtg  1573



<210> 5899
<211> 857
<212> PRT
<213> Homo sapiens
<308> P13639
<400> 5899

Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys Ala 
  1               5                  10                  15
Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys Ser 
             20                  25                  30
Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser Ala 
         35                  40                  45
Arg Ala Gly Glu Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln Glu 
     50                  55                  60
Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu Leu 
 65                  70                  75                  80
Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ala Gly 
                 85                  90                  95
Phe Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser Ser 
             100                105                110
Glu Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val Val 
         115                120                125
Asp Cys Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg Gln 
     130                135                140
Ala Ile Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met Asp 
 145                150                155                160
Arg Ala Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln Thr 
                 165                170                175
Phe Gln Arg Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr Gly 
             180                185                190
Glu Gly Glu Ser Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val Leu 
         195                200                205
Gly Thr Val Gly Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr Leu 
     210                215                220
Lys Gln Phe Ala Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly Glu 
 225                230                235                240
Gly Gln Leu Gly Pro Ala Glu Arg Ala Lys Lys Val Glu Asp Met Met 
                 245                250                255
Lys Lys Leu Trp Gly Asp Arg Tyr Phe Asp Pro Ala Asn Gly Lys Phe 
             260                265                270
Ser Lys Ser Ala Thr Ser Pro Glu Gly Lys Lys Leu Pro Arg Thr Phe 
         275                280                285
Cys Gln Leu Ile Leu Asp Pro Ile Phe Lys Val Phe Asp Ala Ile Met 
     290                295                300
Asn Phe Lys Lys Glu Glu Thr Ala Lys Leu Ile Glu Lys Leu Asp Ile 
 305                310                315                320
Lys Leu Asp Ser Glu Asp Lys Asp Lys Glu Gly Lys Pro Leu Leu Lys 
                 325                330                335
Ala Val Met Arg Arg Trp Leu Pro Ala Gly Asp Ala Leu Leu Gln Met 
             340                345                350
Ile Thr Ile His Leu Pro Ser Pro Val Thr Ala Gln Lys Tyr Arg Cys 
         355                360                365
Glu Leu Leu Tyr Glu Gly Pro Pro Asp Asp Glu Ala Ala Met Gly Ile 
     370                375                380
Lys Ser Cys Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys Met 
 385                390                395                400
Val Pro Thr Ser Asp Lys Gly Arg Phe Tyr Ala Phe Gly Arg Val Phe 
                 405                410                415
Ser Gly Leu Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro Asn 
             420                425                430
Tyr Thr Pro Gly Lys Lys Glu Asp Leu Tyr Leu Lys Pro Ile Gln Arg 
         435                440                445
Thr Ile Leu Met Met Gly Arg Tyr Val Glu Pro Ile Glu Asp Val Pro 
     450                455                460
Cys Gly Asn Ile Val Gly Leu Val Gly Val Asp Gln Phe Leu Val Lys 
 465                470                475                480
Thr Gly Thr Ile Thr Thr Phe Glu His Ala His Asn Met Arg Val Met 
                 485                490                495
Lys Phe Ser Val Ser Pro Val Val Arg Val Ala Val Glu Ala Lys Asn 
             500                505                510
Pro Ala Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg Leu Ala Lys 
         515                520                525
Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly Glu His Ile 
     530                535                540
Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu Lys Asp Leu 
 545                550                555                560
Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp Pro Val Val 
                 565                570                575
Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu Cys Leu Ser 
             580                585                590
Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala Arg Pro Phe 
         595                600                605
Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val Ser Ala Arg 
     610                615                620
Gln Glu Leu Lys Gln Arg Ala Arg Tyr Leu Ala Glu Lys Tyr Glu Trp 
 625                630                635                640
Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro Asp Gly Thr 
                 645                650                655
Gly Pro Asn Ile Leu Thr Asp Ile Thr Lys Gly Val Gln Tyr Leu Asn 
             660                665                670
Glu Ile Lys Asp Ser Val Val Ala Gly Phe Gln Trp Ala Thr Lys Glu 
         675                680                685
Gly Ala Leu Cys Glu Glu Asn Met Arg Gly Val Arg Phe Asp Val His 
     690                695                700
Asp Val Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln Ile 
 705                710                715                720
Ile Pro Thr Ala Arg Arg Cys Leu Tyr Ala Ser Val Leu Thr Ala Gln 
                 725                730                735
Pro Arg Leu Met Glu Pro Ile Tyr Leu Val Glu Ile Gln Cys Pro Glu 
             740                745                750
Gln Val Val Gly Gly Ile Tyr Gly Val Leu Asn Arg Lys Arg Gly His 
         755                760                765
Val Phe Glu Glu Ser Gln Val Ala Gly Thr Pro Met Phe Val Val Lys 
     770                775                780
Ala Tyr Leu Pro Val Asn Glu Ser Phe Gly Phe Thr Ala Asp Leu Arg 
 785                790                795                800
Ser Asn Thr Gly Gly Gln Ala Phe Pro Gln Cys Val Phe Asp His Trp 
                 805                810                815
Gln Ile Leu Pro Gly Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser Gln 
             820                825                830
Val Val Ala Glu Thr Arg Lys Arg Lys Gly Leu Lys Glu Gly Ile Pro 
         835                840                845
Ala Leu Asp Asn Phe Leu Asp Lys Leu 
     850                855



<210> 5900
<211> 499
<212> DNA
<213> Rattus norvegicus
<308> AA892805
<400> 5900

agctgatgc  gccttggtg  aagctgctg  cagtataga  catggtaat  gcacgtata  60
agcatggtt  tagcatgtg  atagcatgt  tatagcatg  atacagcat  gggtcaacg  120
cgtgaaaca  actgtttca  tgcaggaga  aagagcgat  ccagaaaca  tttccaact  180
actttgcca  tgttaatca  tctgagtgt  tgcagccat  ctggagagc  agcttattg  240
gactgtctt  ctgggccag  tcccgctgc  gcagcacca  ggtgcccgt  cctggcggt  300
ggctgctgt  cttctggcg  tccttgccc  ggggtcgta  caccacctg  tgtgactct  360
cctcggagg  gtccccgga  tccccgctg  cattcttga  catgtaaac  tgactgttt  420
gagtcctac  gacaacagc  gggccttgg  aggtcttgg  taacacttc  ttctgcctc  480
tttcctttc  taacttttc  499



<210> 5901
<211> 1042
<212> DNA
<213> Homo sapiens
<308> BG420645
<400> 5901

gggggcctg  acgaggggg  cgcggtctg  ctagggagc  gcgcgggct  atggcgtga  60
gaaaatgag  cacgaggaa  tgttaacca  gaccttcca  ggcccagct  ttgtgtgtg  120
gactccgac  agccacgta  acatgttta  gaatggcag  ggggactcg  gggactctt  180
tgaagaaga  tctcaccgt  tggttttgc  gccccgggg  aaggagcgc  acaagagcg  240
tgtccacca  cctccccag  cgggagcag  tgacgtggt  ctgctgcag  gggagctgg  300
ccaggagga  agcctcaac  agctggcgc  gcagtatgg  tgcaaagtt  cagatatca  360
gaaagtcaa  aacttcatc  gagaacaag  cttatatgc  ttgaaatct  ttaagattc  420
agtgagaaa  catgggatc  tgatggaga  ccacaaaga  ctgaaaccc  ttctgagcc  480
gtcttccga  accacagtg  ccgtggaac  gccagaggc  gacagagca  gcgcgggca  540
cggtgccca  gccggccaa  tgatgggct  ctttaaggg  atcgaccag  atattgagc  600
tggagtgca  tcagaaatc  ttctacatg  acagttact  catggacac  tcccatcag  660
cactgctcc  ggcaactcc  aagaacgcc  atggatggt  cacattgtg  catcagtgg  720
ggaatgctg  ttactccag  ctgcagaat  ggcatcggc  ggccggcca  gaatcaggg  780
caacttcac  atacaaagc  aagggtgag  acccctaat  agcatgaac  ccactgctc  840
tccccaagg  tccgaggca  gggctaccg  ccaggcaag  catcaacac  gcttgaaga  900
aagccgatg  acttggcac  gagacagtc  acaaagcac  cagagcgag  acagcgtcg  960
cataagagc  ggcgcggaa  aaaaaggac  aagcgagga  aagagcaag  agacagcag  1020
cgcactagt  ccgcgaaga  gc  1042



<210> 5902
<211> 664
<212> DNA
<213> Rattus norvegicus
<308> AA892813
<400> 5902

ggccacagt  atggcattc  ctcccggtg  tcttcaccc  ttaccaaag  gacaagcac  60
tgcaaaaaa  caacggagc  agcacggtc  tcaacccca  cgtcttgca  taccagcag  120
ctttgacca  tgcgcagtt  cagcaacac  cggcgttca  tcccacagt  cccatgatg  180
acagcgcta  gtccgccac  gtctctgca  caacaactc  tgcaacaag  gtccccttc  240
cagcaacag  cacagccaa  cagataatt  tgaaataat  aacagaaat  gaatggaat  300
ccaagaatc  gcattgaga  taactaaac  ttgttactg  acatactat  ccctttgct  360
ctcaataga  ttgccacaa  ctgcatgct  aatttagtt  ttccggaca  accgcaacc  420
taaggctag  tctgctatg  catatacga  tattaaata  ggtatgctt  gtatattcc  480
gcctaagat  gttaactac  tgagaccag  tgcgatgtt  aaagacata  aggatgagg  540
tttctttta  agggttctg  gcgtagttt  tgtcccagg  atattgtct  atctccata  600
ctatagccg  tgcaaaaag  ccacccagt  tacacattt  gactcagaa  acttcaaat  660
tagc  664



<210> 5903
<211> 2595
<212> DNA
<213> Homo sapiens
<308> AF061261
<400> 5903

ctgaaggta  aattttcca  atacggcag  cggctttca  agtacaata  acagggaat  60
agaactatt  acatggaag  ttctttctc  tgatgcggt  gagaagcct  ggccacttg  120
ttctgccag  tgttcctgg  gttactgta  atgggaagg  caggcagag  taaacaagg  180
ttatcattt  aaagtgcct  ytgtgaagt  acttttgct  gaaaactgc  gcttggagc  240
ttctttgta  tcacatccc  ctcttctgt  aagtacact  taccctgac  ttatgagtg  300
atgaagata  ctcagttgt  tgactttgc  aattgctta  tttcagaat  taaaaaggg  360
aaagaaaaa  atcctgcta  aatatgaac  tctgagtgt  ttattttcc  acatcgtca  420
tagctgtga  cgtcagcat  aaatattct  ccaaggagt  ccatgatat  gaagtcact  480
tattaataa  agctgtatc  gcaaaacag  caagagact  ggacgttga  agccagaga  540
gacactgag  atgctttta  tgcggccta  catctttaa  tgggacata  tgattgatg  600
gtgattgcc  gtccataca  tctctcatc  tcctgttcc  tggattgga  ttcactaag  660
aatttatca  tcaccttca  acttacatg  gggagtttt  acaacagta  ttttggaat  720
attagaact  ggattgatt  catcattta  cagaaacaa  cagcccaaa  tactttatc  780
ccatggctt  gaacgttgc  ccagtcaga  atacaaaat  gctgacatt  gaagtctgc  840
gacagtttc  aagaggaac  tgctcacgc  ctgatgaag  atgcaaatt  gctcatccc  900
ccaaaagtt  tcaggttga  aatggaaga  taattgcct  ctttgattc  ctaaagggc  960
gttgttcga  agagaactg  aagtatctt  accctccga  acacttaaa  actcaacta  1020
aaattaatg  aaggaacaa  ttgattcag  aaaaaactg  agcagcaat  cttgcccag  1080
agatgcaat  tatgtttcc  ggaacacca  ttcatccag  gcccacttt  cctgtaggt  1140
ccgcgatag  gacaaatac  gctattagc  ttgctcctt  cctagcacc  gtaacccct  1200
gagttgggt  ggtcccaac  gaaattctg  ccaccacgc  tgttattgt  cccggaagt  1260
caccggtca  tgtcccggg  tcaactgca  ctcagaaac  tctcaggac  gacaaactg  1320
aggtatgca  ggagttcca  cgaggaaac  gtgcccggg  agagaccga  tgccgcttt  1380
cacaccccg  agacagcac  atgatcgac  caagtgaca  caccgtaac  gtttgtatg  1440
attacataa  ggggcgttg  atgagggag  aatgcaaat  ttttcaccc  cctgcacac  1500
tgcaggcca  aatcaaagc  gcgcagccg  ggccgcggc  acagtcatg  ctcagtcga  1560
tgccaaagc  atgaagcga  ctctcgaag  aactgtaga  ctggccttt  cccctggtg  1620
tcttcatcc  ttaccaaag  gacaagcac  tgaaaaaag  aatggtacc  gcgcggtct  1680
taaccccag  gtcttgcac  accagcagg  tctcaccag  gcacagttg  agcaacacg  1740
cgcgttcat  ccaacaggg  cagttttgt  catgacacc  gctaccagt  ttgtaccca  1800
gatgcacag  gctacgtcc  ccactgtct  tgcagcaac  actcctgca  caagtgtcc  1860
cttcgcagc  acagccaca  ccaatcaga  aattctgaa  taatcagca  aaacggaat  1920
gaatgccaa  aatctgcat  gagaataac  aaacattgt  actgtacat  ctatcctgt  1980
tcctcctca  tagaattgc  acaaactgc  tgctaaata  agatgtagt  cttctggac  2040
gaccacaac  ctaagaagc  agtgctgct  tctcatata  gagtattaa  tatggtatg  2100
ttagtatat  ccaacctaa  atagttaac  acctgagac  agctgtgat  tttaaagac  2160
taaaggata  agtttactt  taaagggtt  ctaaacata  tttctgtcc  aggaatatt  2220
tcttatctc  ataactata  agctgatgc  gaaagtcca  ccagtttac  catttcgat  2280
cagaatatt  caaatttag  aataaacaa  tagcattag  taaaaaaga  acatattcc  2340
agggcaggt  cgattctag  tctaattac  gtcatgtca  ttacccact  gatcaaagg  2400
tatgtttca  ttcttgaca  tataaatgc  gcagcaaag  tgagaggtg  agtaaaacc  2460
atacctgtc  tgcaggtct  aaatttgaa  ggaaattca  gcacaagta  tggggacac  2520
tcaaagtgt  gtgtttggt  tgcctggag  tgccacgtt  aatcatgtg  ttctagagt  2580
gacctgcag  catgc  2595



<210> 5904
<211> 256
<212> PRT
<213> Homo sapiens
<308> AF061261
<400> 5904

Met Ala Leu Asn Val Ala Pro Val Arg Asp Thr Lys Trp Leu Thr Leu 
  1               5                  10                  15
Glu Val Cys Arg Gln Phe Gln Arg Gly Thr Cys Ser Arg Ser Asp Glu 
             20                  25                  30
Glu Cys Lys Phe Ala His Pro Pro Lys Ser Cys Gln Val Glu Asn Gly 
         35                  40                  45
Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
     50                  55                  60
Asn Cys Lys Tyr Leu His Pro Pro Thr His Leu Lys Thr Gln Leu Glu 
 65                  70                  75                  80
Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Thr Ala Ala Ala Met 
                 85                  90                  95
Leu Ala Gln Gln Met Gln Phe Met Phe Pro Gly Thr Pro Leu His Pro 
             100                105                110
Val Pro Thr Phe Pro Val Gly Pro Ala Ile Gly Thr Asn Thr Ala Ile 
         115                120                125
Ser Phe Ala Pro Tyr Leu Ala Pro Val Thr Pro Gly Val Gly Leu Val 
     130                135                140
Pro Thr Glu Ile Leu Pro Thr Thr Pro Val Ile Val Pro Gly Ser Pro 
 145                150                155                160
Pro Val Thr Val Pro Gly Ser Thr Ala Thr Gln Lys Leu Leu Arg Thr 
                 165                170                175
Asp Lys Leu Glu Val Cys Arg Glu Phe Gln Arg Gly Asn Cys Ala Arg 
             180                185                190
Gly Glu Thr Asp Cys Arg Phe Ala His Pro Ala Asp Ser Thr Met Ile 
         195                200                205
Asp Thr Ser Asp Asn Thr Val Thr Val Cys Met Asp Tyr Ile Lys Gly 
     210                215                220
Arg Cys Met Arg Glu Lys Cys Lys Tyr Phe His Pro Pro Ala His Leu 
 225                230                235                240
Gln Ala Lys Ile Lys Ala Ala Gln Pro Arg Pro Arg Pro Gln Ser Ter 
                 245                250                255



<210> 5905
<211> 543
<212> DNA
<213> Rattus norvegicus
<308> AA892818
<400> 5905

gcatctcca  tcatgcttt  ttctgcaga  ggaaattct  tggcctgcc  ttcacctct  60
ctttctcat  agaacagaa  tgtgttagt  caggccctc  agaccctgc  cccatccag  120
gagtataat  tactcaaga  ggagtagct  tgtgtgcat  cagatatgt  tgtatatgt  180
taggtatat  catatgtat  tatatacat  tacacatat  tattttggc  gtacagtat  240
tataggtat  gggaaaaca  gattaacat  acaatgata  ctgcaaccc  tcgaatcca  300
ttaaatcag  caaagacaa  gaaagcacc  cttggcctc  gaatggctg  ttggtttct  360
tctgaacaa  cataaccag  agatggaat  gatcaggct  gtatcaagc  cagaatggc  420
aaaggaggc  cttccttgt  tttttccag  gtgtctact  taggaatgg  ctgttcttt  480
gggttctct  tctctctct  tctctccct  tctctctct  tctctctct  tctctctct  540
tgt  543



<210> 5906
<211> 590
<212> DNA
<213> Rattus norvegicus
<308> AA892820
<400> 5906

catggagca  acattttat  taataagtt  taagataca  tttccagtc  gcatttgtt  60
cagtttggt  tccatggct  ctaagcctg  atccctttc  catccagct  cagctgctc  120
gggtcctaa  gggtggctt  tagcaccca  acctctctg  ctgccgtgc  ttggtgcgg  180
acacctact  cacccctac  atatccacg  caacagcca  aacacccga  tttgagggg  240
aaggggtat  tgacagcct  gaaatgctt  caccaaagc  tttaaagag  ccctaggtg  300
atgtgttag  gccttggtc  ttaaggcct  tcatgggtc  taacagggg  gggtatcca  360
cccttccag  ttttgcaag  aggaggtcc  acagtaatt  atcagtggc  tctgccatt  420
agcacaagc  atggactct  ggggcagct  acagaggct  tgcatttgg  catgaccac  480
tgtcttcaa  aaagtaggc  agagcagaa  ccctcctac  ccagagctg  ctttgcgat  540
aagtcaaag  ggtcagggc  cagacatgg  gaacgatct  ggtcagactt  590



<210> 5907
<211> 4879
<212> DNA
<213> Homo sapiens
<308> AB007899
<400> 5907

gcccgggtg  gtggctgcg  agggcccta  ctgggcggg  gcggctgca  agccctgtc  60
acgcggtgc  tccccagca  ggcacctcc  actccaggc  gttggttac  tggccggga  120
ctggcagag  ccaggattt  tcctcgccg  cgttgctgt  gttagggga  acagaccat  180
tgcatctag  cctgcctct  tctccgctc  ccacttcag  cgagctctt  ctgcctgga  240
tctgtgatc  gtatgtgaa  ctttcattg  acgtagcgg  tgagaatag  gaacttgct  300
tggtccaga  aaaaacaat  aaaaagaca  tgaacccaa  atggaatga  gaattttat  360
tcagggtaa  cccatctaa  cacagactc  tatttgaag  atttgacga  aatagactg  420
cacgagacg  cttcctggg  caggtggac  tgcccctta  tcaccttcc  acagaagat  480
caaccatgg  gcgacccta  acatttaag  actttctcc  cagaccaag  agtcataag  540
ctcgagtta  gggattttt  cgattgaaa  tggcctata  gccaaaaaa  ggaggtcaa  600
atgaagaaa  cagtgacca  agggatgac  tggagcatg  atgggaagt  gttgactca  660
atgactcgg  ttctcagca  caagaggaa  ttcctcctc  tcctctgcc  cccgggtgg  720
aagaaaaag  ggacaattt  ggccgaact  actatgtca  ccacaacaa  cggaccact  780
agtggcaca  accaagcct  atggacgtg  cctcggagt  ggacaataa  atcagacag  840
tcaaccagg  ggcagcaca  cggcgcttc  gctcccgca  gcacatcag  gaagacttg  900
agcccgagc  ctcggaggg  ggggatgtc  ccgagcctt  ggagaccat  tcagaggaa  960
tgaatatcg  tggagactc  ctcggtctg  ctctgcccc  accaccggc  tccccagga  1020
ctcggacca  ccctcagga  ctgtcagag  aactaagca  aaggcttca  atcactcca  1080
actccaatg  ggaacagtt  agctctttg  ttcaaagag  accctcctc  aggttgagg  1140
catgcagtg  caccgacgc  gttgcagaa  agggccatc  accaccgcc  tcagtggcc  1200
atgtacata  cacgccggg  ctgccttca  gctgggaag  aagaaaaga  gctaagggg  1260
gcacatact  tgtcaatca  aacaatcga  ccacaactt  gactcgacc  atcatgcag  1320
ttgcagaag  tggtgcgtc  ggatcagcc  caaacagta  caaccatct  atcgagcct  1380
agatccgcc  gcctcgtag  ctcagctcg  caacagtaa  tttatctgc  ccgctggag  1440
gtgccaagg  ctcacccgt  cgtcgggct  tgaaagaca  cctttccaa  ccacagtcc  1500
cacagccat  accttacaa  tcccccaaa  cacaacaca  agtcacaca  agcttcttg  1560
cacccggct  ggaaatgag  atagcgcca  acggccggc  cttcttcat  gatcataac  1620
caaagacta  aacctggga  gatccacgt  tgaaatttc  agtacatat  cggtcaaag  1680
catctttaa  ccccaatga  cttggcccc  ttcctcctg  ctgggaaga  agaattcac  1740
tggatggcc  aacgtttta  attgatcat  atagcaaaa  tactcagtg  gaagaccca  1800
gactgcaga  cccagctat  actggtccg  ctgtccctt  ctccagaga  tttaagcag  1860
aatatgact  cttcaggaa  aaattaaag  aacctgctg  tatccccaa  aggtttgaa  1920
tgaaacttc  cagaaataa  atatttgaa  agtcctatc  gagaattat  tccgtgaaa  1980
gaccagatg  cctaaaagc  agactgtgg  ttgagtttg  atcagagaa  ggtcttgac  2040
atgggggtg  ggccagaga  tggttcttc  tactgtcca  agagatgtt  aacccctac  2100
acggcctct  tgagtactc  gccacggac  actacaccc  tcagatcaa  cctaattca  2160
gcctctgta  tgaggatca  ttgtcctac  tcactttta  tggaagagt  gctggtctg  2220
ccgtatttc  tgggaagct  ttagatggt  tcttcatta  accatttta  aagatgatg  2280
tgggaaagc  gataaccct  aatgacatg  aatctgtgg  tagtgaata  tacaactct  2340
tgaaatgga  cctggagaa  gaccctact  agctggacc  catgttctg  atagacgaa  2400
aaaactttg  acagacata  caagtggat  tgaagccca  tgggtcaga  ataatggtc  2460
caaatgaaa  caaaaggga  tatatcgac  tagtcatcc  gtggagatt  gtgaacagg  2520
tccagaagc  gatgaacgc  ttcttggag  gattcacag  actacttcc  attgatttg  2580
ttaaaattt  tgacgaaaa  gagctggag  tgctcatgt  cggcctcgg  gatgtggat  2640
tgaatgact  gagacagca  tctatttac  agaacggct  ctgcccaaa  caccccgtc  2700
ttcagtggt  ctggaaggc  gtgctactc  tggacgccg  aaagcgtat  cggttactg  2760
agtttgtca  agggacatc  cgagtacct  tgaatggat  tgccgaact  tatggttcc  2820
atggtcctc  gctgtttac  atagagcaa  ggggcagtc  tgagaaact  cccagagct  2880
acacatgct  taatcgcct  gacttacct  catatgaaa  ctttgaaga  ttacgagag  2940
aacttctca  ggccgtgga  aatgctcaa  gatttgaag  ggtggatta  gcaccctgt  3000
cctcggggg  ggttgttct  caagcaagt  ctgcttgca  ttttgcatt  gcctaacag  3060
cttttgcag  ggcgatggc  gagagcagc  gcaggcatg  tccctggag  cgagccttc  3120
ccacgcact  gtccaagtt  ggatgcggg  acctggtcc  agcttgagt  cctgccttt  3180
ccaccacaa  ttatcaact  gttgatgtg  acactaatt  catttcagg  ggacttaat  3240
ctatttatg  tgtgcctct  caggcaaag  ccttaataa  tattttaca  cctttctaa  3300
gacaatgaa  ggaattaat  actcaacag  tatagtatt  cgactcatg  ttacttttt  3360
aaatgattt  gaccgattt  cagatttta  ttcgttatg  ttaaagatg  ctcatgtac  3420
tggaaaagt  agcattttt  ttttttttt  tatttcact  tcataccag  cttaatgtc  3480
atgacattt  tatttttga  gtactctga  acctccacc  tctacttta  tagaattgg  3540
aggcaaatt  ttgtccaaa  acctacaga  aagtacttt  agagaattt  caatataat  3600
ttagacata  tgataattt  ttccatact  agaatgaaa  actggatat  acgtttttg  3660
tttggggtt  ttttgtaca  atttagcta  tagctacag  ctgagagaa  tgtaacata  3720
catgacaaa  tttgtgttg  cttgaaagg  atcacacca  tattcctta  aagtaatta  3780
atgtgttct  acacatttg  gacagggtt  gactcccat  tctcatccg  gaaattact  3840
aacccttcc  ggcgctgta  agtcatctt  tattctatt  cctctttgc  gtttgtagt  3900
gagacattt  gaatgaaac  tggcactgc  tgattcaaa  ctgtggaaa  cagatctgt  3960
tagtctcct  tttgtatgc  tttgctaat  gtagctaaa  aaccagttt  tgttgtaaa  4020
gcaccaatt  tgaaggcac  ttatgtact  catggaggt  atatctggt  ttgttttta  4080
ttttttatc  tgaacatta  atgtgatga  gatttcttt  ccctgcaca  atctttccg  4140
tgcaatatc  atcaattgt  aatctggct  ctggtgtat  aaaacctgg  tgtaaagct  4200
agcctacag  cctgtcctc  ccaactgtt  tgtgatttc  actcaacta  aaagattta  4260
ttaatgtac  cttaatcta  ctgagtttt  ttaccaatg  cctgttgca  gcttcaata  4320
cgtgtactg  ctgagttgt  cctcttgtg  gctagatta  aagtgagac  gagacttga  4380
ttgatcctc  gagctcaag  tattgagct  gtagtggca  aggactgag  gtacctgca  4440
agtttgatt  ttttccacg  gtaagtctc  attgcagaa  tgtcgtgct  tgagaaaac  4500
cctgaggca  tgtgggagt  gaacgaccc  gctgtcctt  ttaacctgt  ttgtcctag  4560
ccctgtcgg  gcagtcagg  gacactaga  atttgatct  atgcgagtc  tcaatagga  4620
aaaaaagtt  tggtttggg  aggtctgtt  gttacataa  aaggacctt  cggtgtaag  4680
aattgccgt  tttaccctg  cctggctgg  atgtgagaa  ccatggaag  ttgtggttg  4740
aaatgagtt  tctaaaggg  tgcagaggc  tgaggtttc  aaaagaagg  agatttcta  4800
agagctgag  gttggttcc  ttttcttat  ggttgaaaa  tacctggta  tgatcagaa  4860
acttagatg  tatgtaact  4879



<210> 5908
<211> 995
<212> PRT
<213> Homo sapiens
<308> BAA23711
<400> 5908

Pro Gly Gly Trp Leu Arg Arg Ala Leu Pro Gly Arg Glu Arg Leu Gln 
  1               5                  10                  15
Ser Pro Val His Ala Val Pro Pro Gln His Gly Thr Ser His Ser Arg 
             20                  25                  30
Leu Leu Val Thr Trp Pro Gly Ala Gly Arg Asp Gln Asp Phe Ser Ser 
         35                  40                  45
Pro Pro Leu Leu Leu Leu Gly Glu Thr Asp His Leu His Leu Asp Leu 
     50                  55                  60
Pro Leu Ser Pro Leu Pro Thr Ser Asp Glu Leu Phe Leu Pro Gly Ile 
 65                  70                  75                  80
Cys Asp Pro Tyr Val Lys Leu Ser Leu Tyr Val Ala Asp Glu Asn Arg 
                 85                  90                  95
Glu Leu Ala Leu Val Gln Thr Lys Thr Ile Lys Lys Thr Leu Asn Pro 
             100                105                110
Lys Trp Asn Glu Glu Phe Tyr Phe Arg Val Asn Pro Ser Asn His Arg 
         115                120                125
Leu Leu Phe Glu Val Phe Asp Glu Asn Arg Leu Thr Arg Asp Asp Phe 
     130                135                140
Leu Gly Gln Val Asp Val Pro Leu Ser His Leu Pro Thr Glu Asp Pro 
 145                150                155                160
Thr Met Glu Arg Pro Tyr Thr Phe Lys Asp Phe Leu Leu Arg Pro Arg 
                 165                170                175
Ser His Lys Ser Arg Val Lys Gly Phe Leu Arg Leu Lys Met Ala Tyr 
             180                185                190
Met Pro Lys Asn Gly Gly Gln Asp Glu Glu Asn Ser Asp Gln Arg Asp 
         195                200                205
Asp Met Glu His Gly Trp Glu Val Val Asp Ser Asn Asp Ser Ala Ser 
     210                215                220
Gln His Gln Glu Glu Leu Pro Pro Pro Pro Leu Pro Pro Gly Trp Glu 
 225                230                235                240
Glu Lys Val Asp Asn Leu Gly Arg Thr Tyr Tyr Val Asn His Asn Asn 
                 245                250                255
Arg Thr Thr Gln Trp His Arg Pro Ser Leu Met Asp Val Ser Ser Glu 
             260                265                270
Ser Asp Asn Asn Ile Arg Gln Ile Asn Gln Glu Ala Ala His Arg Arg 
         275                280                285
Phe Arg Ser Arg Arg His Ile Ser Glu Asp Leu Glu Pro Glu Pro Ser 
     290                295                300
Glu Gly Gly Asp Val Pro Glu Pro Trp Glu Thr Ile Ser Glu Glu Val 
 305                310                315                320
Asn Ile Ala Gly Asp Ser Leu Gly Leu Ala Leu Pro Pro Pro Pro Ala 
                 325                330                335
Ser Pro Gly Ser Arg Thr Ser Pro Gln Glu Leu Ser Glu Glu Leu Ser 
             340                345                350
Arg Arg Leu Gln Ile Thr Pro Asp Ser Asn Gly Glu Gln Phe Ser Ser 
         355                360                365
Leu Ile Gln Arg Glu Pro Ser Ser Arg Leu Arg Ser Cys Ser Val Thr 
     370                375                380
Asp Ala Val Ala Glu Gln Gly His Leu Pro Pro Pro Ser Val Ala Tyr 
 385                390                395                400
Val His Thr Thr Pro Gly Leu Pro Ser Gly Trp Glu Glu Arg Lys Asp 
                 405                410                415
Ala Lys Gly Arg Thr Tyr Tyr Val Asn His Asn Asn Arg Thr Thr Thr 
             420                425                430
Trp Thr Arg Pro Ile Met Gln Leu Ala Glu Asp Gly Ala Ser Gly Ser 
         435                440                445
Ala Thr Asn Ser Asn Asn His Leu Ile Glu Pro Gln Ile Arg Arg Pro 
     450                455                460
Arg Ser Leu Ser Ser Pro Thr Val Thr Leu Ser Ala Pro Leu Glu Gly 
 465                470                475                480
Ala Lys Asp Ser Pro Val Arg Arg Ala Val Lys Asp Thr Leu Ser Asn 
                 485                490                495
Pro Gln Ser Pro Gln Pro Ser Pro Tyr Asn Ser Pro Lys Pro Gln His 
             500                505                510
Lys Val Thr Gln Ser Phe Leu Pro Pro Gly Trp Glu Met Arg Ile Ala 
         515                520                525
Pro Asn Gly Arg Pro Phe Phe Ile Asp His Asn Thr Lys Thr Thr Thr 
     530                535                540
Trp Glu Asp Pro Arg Leu Lys Phe Pro Val His Met Arg Ser Lys Thr 
 545                550                555                560
Ser Leu Asn Pro Asn Asp Leu Gly Pro Leu Pro Pro Gly Trp Glu Glu 
                 565                570                575
Arg Ile His Leu Asp Gly Arg Thr Phe Tyr Ile Asp His Asn Ser Lys 
             580                585                590
Ile Thr Gln Trp Glu Asp Pro Arg Leu Gln Asn Pro Ala Ile Thr Gly 
         595                600                605
Pro Ala Val Pro Tyr Ser Arg Glu Phe Lys Gln Lys Tyr Asp Tyr Phe 
     610                615                620
Arg Lys Lys Leu Lys Lys Pro Ala Asp Ile Pro Asn Arg Phe Glu Met 
 625                630                635                640
Lys Leu His Arg Asn Asn Ile Phe Glu Glu Ser Tyr Arg Arg Ile Met 
                 645                650                655
Ser Val Lys Arg Pro Asp Val Leu Lys Ala Arg Leu Trp Ile Glu Phe 
             660                665                670
Glu Ser Glu Lys Gly Leu Asp Tyr Gly Gly Val Ala Arg Glu Trp Phe 
         675                680                685
Phe Leu Leu Ser Lys Glu Met Phe Asn Pro Tyr Tyr Gly Leu Phe Glu 
     690                695                700
Tyr Ser Ala Thr Asp Asn Tyr Thr Leu Gln Ile Asn Pro Asn Ser Gly 
 705                710                715                720
Leu Cys Asn Glu Asp His Leu Ser Tyr Phe Thr Phe Ile Gly Arg Val 
                 725                730                735
Ala Gly Leu Ala Val Phe His Gly Lys Leu Leu Asp Gly Phe Phe Ile 
             740                745                750
Arg Pro Phe Tyr Lys Met Met Leu Gly Lys Gln Ile Thr Leu Asn Asp 
         755                760                765
Met Glu Ser Val Asp Ser Glu Tyr Tyr Asn Ser Leu Lys Trp Ile Leu 
     770                775                780
Glu Asn Asp Pro Thr Glu Leu Asp Leu Met Phe Cys Ile Asp Glu Glu 
 785                790                795                800
Asn Phe Gly Gln Thr Tyr Gln Val Asp Leu Lys Pro Asn Gly Ser Glu 
                 805                810                815
Ile Met Val Thr Asn Glu Asn Lys Arg Glu Tyr Ile Asp Leu Val Ile 
             820                825                830
Gln Trp Arg Phe Val Asn Arg Val Gln Lys Gln Met Asn Ala Phe Leu 
         835                840                845
Glu Gly Phe Thr Glu Leu Leu Pro Ile Asp Leu Ile Lys Ile Phe Asp 
     850                855                860
Glu Asn Glu Leu Glu Leu Leu Met Cys Gly Leu Gly Asp Val Asp Val 
 865                870                875                880
Asn Asp Trp Arg Gln His Ser Ile Tyr Lys Asn Gly Tyr Cys Pro Asn 
                 885                890                895
His Pro Val Ile Gln Trp Phe Trp Lys Ala Val Leu Leu Met Asp Ala 
             900                905                910
Glu Lys Arg Ile Arg Leu Leu Gln Phe Val Thr Gly Thr Ser Arg Val 
         915                920                925
Pro Met Asn Gly Phe Ala Glu Leu Tyr Gly Ser Asn Gly Pro Gln Leu 
     930                935                940
Phe Thr Ile Glu Gln Trp Gly Ser Pro Glu Lys Leu Pro Arg Ala His 
 945                950                955                960
Thr Cys Phe Asn Arg Leu Asp Leu Pro Pro Tyr Glu Thr Phe Glu Asp 
                 965                970                975
Leu Arg Glu Lys Leu Leu Met Ala Val Glu Asn Ala Gln Gly Phe Glu 
             980                985                990
Gly Val Asp 
         995



<210> 5909
<211> 503
<212> DNA
<213> Rattus norvegicus
<308> AA892821
<400> 5909

aggtcggac  cctgcttta  tcagacggg  aaagagcag  gagtggatg  agaccagca  60
aaaagacca  actaggtca  cactgggca  ggagtggcc  gggtgtgac  ctaagagtt  120
gcagaaaag  cctggcgtc  tgagtcacg  cagtctatc  gaagtagtt  ggacactcg  180
gggcgacca  gttccaggc  tggttaaag  cctccacga  agcgggctc  aggggacct  240
cctcagtgg  cgccaagtt  tgctccagc  gctccaggc  ggacatgcc  aagatgact  300
cgtcccctc  ggtgccctg  agctgtgag  gatggtaca  ccagcgcag  gcagccgag  360
tcatgctgg  ggcactggt  ccataggtg  tcttcaggg  cttttctac  agggcaatg  420
cctcaaagt  gtgttcctt  cagaagcgg  tcctgtagg  ctcagacca  ctattccca  480
agaagcggc  ctcgggctg  ttc  503



<210> 5910
<211> 338
<212> PRT
<213> Rattus norvegicus
<308> BAA90396
<400> 5910

Met Ser Arg Ser Pro Ala Pro Arg Ala Val Ser Gly Ala Pro Leu Arg 
  1               5                  10                  15
Pro Gly Thr Val Leu Gly Thr Met Glu Met Gly Arg Arg Met Asp Ala 
             20                  25                  30
Ser Ala Ser Ala Ala Thr Val Arg Ala Phe Leu Glu Arg Gly Leu Asn 
         35                  40                  45
Glu Leu Asp Thr Ala Phe Met Tyr Cys Asp Gly Gln Ser Glu Ser Ile 
     50                  55                  60
Leu Gly Ser Leu Gly Leu Gly Leu Gly Ser Gly Asp Cys Thr Val Lys 
 65                  70                  75                  80
Ile Ala Thr Lys Ala Asn Pro Trp Asp Gly Lys Ser Leu Lys Pro Asp 
                 85                  90                  95
Ser Val Arg Ser Gln Leu Glu Thr Ser Leu Lys Arg Leu Gln Cys Pro 
             100                105                110
Arg Val Asp Leu Phe Tyr Leu His Ala Pro Asp His Gly Thr Pro Ile 
         115                120                125
Val Glu Thr Leu Gln Ala Cys Gln Gln Leu His Gln Glu Gly Lys Phe 
     130                135                140
Val Glu Leu Gly Leu Ser Asn Tyr Ala Ser Trp Glu Val Ala Glu Ile 
 145                150                155                160
Tyr Thr Leu Cys Lys Ser Asn Gly Trp Ile Leu Pro Thr Val Tyr Gln 
                 165                170                175
Gly Met Tyr Asn Ala Thr Thr Arg Gln Val Glu Thr Glu Leu Leu Pro 
             180                185                190
Cys Leu Arg Tyr Phe Gly Leu Arg Phe Tyr Ala Tyr Asn Pro Leu Ala 
         195                200                205
Gly Gly Leu Leu Thr Gly Lys Tyr Arg Tyr Glu Asp Lys Asp Gly Lys 
     210                215                220
Gln Pro Glu Gly Arg Phe Phe Gly Asn Ser Trp Ser Glu Thr Tyr Arg 
 225                230                235                240
Asn Arg Phe Trp Lys Glu His His Phe Glu Ala Ile Ala Leu Val Glu 
                 245                250                255
Lys Ala Leu Lys Thr Thr Tyr Gly Thr Ser Ala Pro Ser Met Thr Ser 
             260                265                270
Ala Ala Leu Arg Trp Met Tyr His His Ser Gln Leu Gln Gly Thr Arg 
         275                280                285
Gly Asp Ala Val Ile Leu Gly Met Ser Ser Leu Glu Gln Leu Glu Gln 
     290                295                300
Asn Leu Ala Ala Thr Glu Glu Gly Pro Leu Glu Pro Ala Val Val Glu 
 305                310                315                320
Ala Phe Asn Gln Ala Trp Asn Val Val Ala His Glu Cys Pro Asn Tyr 
                 325                330                335
Phe Arg 
             340



<210> 5911
<211> 1319
<212> DNA
<213> Homo sapiens
<308> Y16675
<400> 5911

ctcgcgtag  ctcccgcgc  gccgtccac  gcgcgcttc  ctctccgcc  cccgaggcc  60
gcgcgctcg  catgtcccg  ccaccgcca  cgcgggtcg  ctcggtgct  ggcaccatg  120
agatggggc  ccgcatgga  gcgcccgcc  gcgccgcgg  cgtgcgcgc  tttctggag  180
gcggccaca  cgaactgga  acggccttc  tgtacagcg  cggccagtc  gagaccatc  240
tgggcggcc  ggggctcgg  ctgggcggt  gcgactgca  agtgaaaat  gccaccaag  300
ccaaccctt  ggatggaaa  tcactaaag  ctgacagtg  ccggtccca  ctggagacg  360
cattgaaga  gctgcagtg  ccccaagtg  acctcttct  cctacacgc  cctgaccac  420
gcaccccgg  ggaagagac  ctgcatgcc  gccagcggc  gcaccagga  ggcaagttc  480
tggagcttg  cctctccaa  tatgctagc  gggaagtgg  cgagatctg  accctctgc  540
agagcaatg  ctggatcct  cccactgtg  accagggca  gtacaacgc  accacccgg  600
aggtggaaa  ggagctctt  ccctgcctc  ggcactttg  actgaggtt  tatgcctac  660
accctctgg  tgggggcct  ctgactggc  agtacaagt  tgaggacaa  gacgggaaa  720
agcctgtgg  ccgcttctt  gggaatagc  gggctgaga  ctacaggaa  cgcttctgg  780
aggagcacc  cttcgaggc  attgcgttg  tggagaagg  cctgcaggc  gcatatggc  840
ccagcgccc  cagtgtgac  tcggctgcc  tccggtgga  gtaccacca  tcacagctg  900
agggtgccc  cggggacgc  gtcatcctg  gcatgtcca  cctggagca  ctggagcag  960
acttggcag  aacagagga  gggcccctg  agccggctg  cgtggatgc  tttaatcaa  1020
cctggcatt  ggttgctca  gaatgtccc  actacttcc  ctaggccca  catggctca  1080
gctgcccaa  gcttttctg  cacctcttt  gttctctca  actgaccag  cttggcctt  1140
agctgactt  gaagggttt  tctgaattg  ctagatcca  gcattattt  tctagcttc  1200
tgccttgct  cctattcac  ttacactgt  aaaggtggg  ggtgagtcc  acttgagcg  1260
ttcctgttg  ataaagcag  cacttgacc  ggctgtagc  taggtcttg  gtgaacccc  1319



<210> 5912
<211> 330
<212> PRT
<213> Homo sapiens
<308> O43488
<400> 5912

Met Ser Arg Pro Pro Pro Pro Arg Val Ala Ser Val Leu Gly Thr Met 
  1               5                  10                  15
Glu Met Gly Arg Arg Met Asp Ala Pro Ala Ser Ala Ala Ala Val Arg 
             20                  25                  30
Ala Phe Leu Glu Arg Gly His Thr Glu Leu Asp Thr Ala Phe Met Tyr 
         35                  40                  45
Ser Asp Gly Gln Ser Glu Thr Ile Leu Gly Gly Leu Gly Leu Gly Leu 
     50                  55                  60
Gly Gly Gly Asp Cys Arg Val Lys Ile Ala Thr Lys Ala Asn Pro Trp 
 65                  70                  75                  80
Asp Gly Lys Ser Leu Lys Pro Asp Ser Val Arg Ser Gln Leu Glu Thr 
                 85                  90                  95
Ser Leu Lys Arg Leu Gln Cys Pro Gln Val Asp Leu Phe Tyr Leu His 
             100                105                110
Ala Pro Asp His Gly Thr Pro Val Glu Glu Thr Leu His Ala Cys Gln 
         115                120                125
Arg Leu His Gln Glu Gly Lys Phe Val Glu Leu Gly Leu Ser Asn Tyr 
     130                135                140
Ala Ser Trp Glu Val Ala Glu Ile Cys Thr Leu Cys Lys Ser Asn Gly 
 145                150                155                160
Trp Ile Leu Pro Thr Val Tyr Gln Gly Met Tyr Asn Ala Thr Thr Arg 
                 165                170                175
Gln Val Glu Thr Glu Leu Phe Pro Cys Leu Arg His Phe Gly Leu Arg 
             180                185                190
Phe Tyr Ala Tyr Asn Pro Leu Ala Gly Gly Leu Leu Thr Gly Lys Tyr 
         195                200                205
Lys Tyr Glu Asp Lys Asp Gly Lys Gln Pro Val Gly Arg Phe Phe Gly 
     210                215                220
Asn Ser Trp Ala Glu Thr Tyr Arg Asn Arg Phe Trp Lys Glu His His 
 225                230                235                240
Phe Glu Ala Ile Ala Leu Val Glu Lys Ala Leu Gln Ala Ala Tyr Gly 
                 245                250                255
Ala Ser Ala Pro Ser Val Thr Ser Ala Ala Leu Arg Trp Met Tyr His 
             260                265                270
His Ser Gln Leu Gln Gly Ala His Gly Asp Ala Val Ile Leu Gly Met 
         275                280                285
Ser Ser Leu Glu Gln Leu Glu Gln Asn Leu Ala Ala Thr Glu Glu Gly 
     290                295                300
Pro Leu Glu Pro Ala Val Val Asp Ala Phe Asn Gln Ala Trp His Leu 
 305                310                315                320
Val Ala His Glu Cys Pro Asn Tyr Phe Arg 
                 325                330



<210> 5913
<211> 503
<212> DNA
<213> Rattus norvegicus
<308> AA892821
<400> 5913

aggtcggac  cctgcttta  tcagacggg  aaagagcag  gagtggatg  agaccagca  60
aaaagacca  actaggtca  cactgggca  ggagtggcc  gggtgtgac  ctaagagtt  120
gcagaaaag  cctggcgtc  tgagtcacg  cagtctatc  gaagtagtt  ggacactcg  180
gggcgacca  gttccaggc  tggttaaag  cctccacga  agcgggctc  aggggacct  240
cctcagtgg  cgccaagtt  tgctccagc  gctccaggc  ggacatgcc  aagatgact  300
cgtcccctc  ggtgccctg  agctgtgag  gatggtaca  ccagcgcag  gcagccgag  360
tcatgctgg  ggcactggt  ccataggtg  tcttcaggg  cttttctac  agggcaatg  420
cctcaaagt  gtgttcctt  cagaagcgg  tcctgtagg  ctcagacca  ctattccca  480
agaagcggc  ctcgggctg  ttc  503



<210> 5914
<211> 338
<212> PRT
<213> Rattus norvegicus
<308> BAA90396
<400> 5914

Met Ser Arg Ser Pro Ala Pro Arg Ala Val Ser Gly Ala Pro Leu Arg 
  1               5                  10                  15
Pro Gly Thr Val Leu Gly Thr Met Glu Met Gly Arg Arg Met Asp Ala 
             20                  25                  30
Ser Ala Ser Ala Ala Thr Val Arg Ala Phe Leu Glu Arg Gly Leu Asn 
         35                  40                  45
Glu Leu Asp Thr Ala Phe Met Tyr Cys Asp Gly Gln Ser Glu Ser Ile 
     50                  55                  60
Leu Gly Ser Leu Gly Leu Gly Leu Gly Ser Gly Asp Cys Thr Val Lys 
 65                  70                  75                  80
Ile Ala Thr Lys Ala Asn Pro Trp Asp Gly Lys Ser Leu Lys Pro Asp 
                 85                  90                  95
Ser Val Arg Ser Gln Leu Glu Thr Ser Leu Lys Arg Leu Gln Cys Pro 
             100                105                110
Arg Val Asp Leu Phe Tyr Leu His Ala Pro Asp His Gly Thr Pro Ile 
         115                120                125
Val Glu Thr Leu Gln Ala Cys Gln Gln Leu His Gln Glu Gly Lys Phe 
     130                135                140
Val Glu Leu Gly Leu Ser Asn Tyr Ala Ser Trp Glu Val Ala Glu Ile 
 145                150                155                160
Tyr Thr Leu Cys Lys Ser Asn Gly Trp Ile Leu Pro Thr Val Tyr Gln 
                 165                170                175
Gly Met Tyr Asn Ala Thr Thr Arg Gln Val Glu Thr Glu Leu Leu Pro 
             180                185                190
Cys Leu Arg Tyr Phe Gly Leu Arg Phe Tyr Ala Tyr Asn Pro Leu Ala 
         195                200                205
Gly Gly Leu Leu Thr Gly Lys Tyr Arg Tyr Glu Asp Lys Asp Gly Lys 
     210                215                220
Gln Pro Glu Gly Arg Phe Phe Gly Asn Ser Trp Ser Glu Thr Tyr Arg 
 225                230                235                240
Asn Arg Phe Trp Lys Glu His His Phe Glu Ala Ile Ala Leu Val Glu 
                 245                250                255
Lys Ala Leu Lys Thr Thr Tyr Gly Thr Ser Ala Pro Ser Met Thr Ser 
             260                265                270
Ala Ala Leu Arg Trp Met Tyr His His Ser Gln Leu Gln Gly Thr Arg 
         275                280                285
Gly Asp Ala Val Ile Leu Gly Met Ser Ser Leu Glu Gln Leu Glu Gln 
     290                295                300
Asn Leu Ala Ala Thr Glu Glu Gly Pro Leu Glu Pro Ala Val Val Glu 
 305                310                315                320
Ala Phe Asn Gln Ala Trp Asn Val Val Ala His Glu Cys Pro Asn Tyr 
                 325                330                335
Phe Arg 
             340



<210> 5915
<211> 1319
<212> DNA
<213> Homo sapiens
<308> Y16675
<400> 5915

ctcgcgtag  ctcccgcgc  gccgtccac  gcgcgcttc  ctctccgcc  cccgaggcc  60
gcgcgctcg  catgtcccg  ccaccgcca  cgcgggtcg  ctcggtgct  ggcaccatg  120
agatggggc  ccgcatgga  gcgcccgcc  gcgccgcgg  cgtgcgcgc  tttctggag  180
gcggccaca  cgaactgga  acggccttc  tgtacagcg  cggccagtc  gagaccatc  240
tgggcggcc  ggggctcgg  ctgggcggt  gcgactgca  agtgaaaat  gccaccaag  300
ccaaccctt  ggatggaaa  tcactaaag  ctgacagtg  ccggtccca  ctggagacg  360
cattgaaga  gctgcagtg  ccccaagtg  acctcttct  cctacacgc  cctgaccac  420
gcaccccgg  ggaagagac  ctgcatgcc  gccagcggc  gcaccagga  ggcaagttc  480
tggagcttg  cctctccaa  tatgctagc  gggaagtgg  cgagatctg  accctctgc  540
agagcaatg  ctggatcct  cccactgtg  accagggca  gtacaacgc  accacccgg  600
aggtggaaa  ggagctctt  ccctgcctc  ggcactttg  actgaggtt  tatgcctac  660
accctctgg  tgggggcct  ctgactggc  agtacaagt  tgaggacaa  gacgggaaa  720
agcctgtgg  ccgcttctt  gggaatagc  gggctgaga  ctacaggaa  cgcttctgg  780
aggagcacc  cttcgaggc  attgcgttg  tggagaagg  cctgcaggc  gcatatggc  840
ccagcgccc  cagtgtgac  tcggctgcc  tccggtgga  gtaccacca  tcacagctg  900
agggtgccc  cggggacgc  gtcatcctg  gcatgtcca  cctggagca  ctggagcag  960
acttggcag  aacagagga  gggcccctg  agccggctg  cgtggatgc  tttaatcaa  1020
cctggcatt  ggttgctca  gaatgtccc  actacttcc  ctaggccca  catggctca  1080
gctgcccaa  gcttttctg  cacctcttt  gttctctca  actgaccag  cttggcctt  1140
agctgactt  gaagggttt  tctgaattg  ctagatcca  gcattattt  tctagcttc  1200
tgccttgct  cctattcac  ttacactgt  aaaggtggg  ggtgagtcc  acttgagcg  1260
ttcctgttg  ataaagcag  cacttgacc  ggctgtagc  taggtcttg  gtgaacccc  1319



<210> 5916
<211> 330
<212> PRT
<213> Homo sapiens
<308> O43488
<400> 5916

Met Ser Arg Pro Pro Pro Pro Arg Val Ala Ser Val Leu Gly Thr Met 
  1               5                  10                  15
Glu Met Gly Arg Arg Met Asp Ala Pro Ala Ser Ala Ala Ala Val Arg 
             20                  25                  30
Ala Phe Leu Glu Arg Gly His Thr Glu Leu Asp Thr Ala Phe Met Tyr 
         35                  40                  45
Ser Asp Gly Gln Ser Glu Thr Ile Leu Gly Gly Leu Gly Leu Gly Leu 
     50                  55                  60
Gly Gly Gly Asp Cys Arg Val Lys Ile Ala Thr Lys Ala Asn Pro Trp 
 65                  70                  75                  80
Asp Gly Lys Ser Leu Lys Pro Asp Ser Val Arg Ser Gln Leu Glu Thr 
                 85                  90                  95
Ser Leu Lys Arg Leu Gln Cys Pro Gln Val Asp Leu Phe Tyr Leu His 
             100                105                110
Ala Pro Asp His Gly Thr Pro Val Glu Glu Thr Leu His Ala Cys Gln 
         115                120                125
Arg Leu His Gln Glu Gly Lys Phe Val Glu Leu Gly Leu Ser Asn Tyr 
     130                135                140
Ala Ser Trp Glu Val Ala Glu Ile Cys Thr Leu Cys Lys Ser Asn Gly 
 145                150                155                160
Trp Ile Leu Pro Thr Val Tyr Gln Gly Met Tyr Asn Ala Thr Thr Arg 
                 165                170                175
Gln Val Glu Thr Glu Leu Phe Pro Cys Leu Arg His Phe Gly Leu Arg 
             180                185                190
Phe Tyr Ala Tyr Asn Pro Leu Ala Gly Gly Leu Leu Thr Gly Lys Tyr 
         195                200                205
Lys Tyr Glu Asp Lys Asp Gly Lys Gln Pro Val Gly Arg Phe Phe Gly 
     210                215                220
Asn Ser Trp Ala Glu Thr Tyr Arg Asn Arg Phe Trp Lys Glu His His 
 225                230                235                240
Phe Glu Ala Ile Ala Leu Val Glu Lys Ala Leu Gln Ala Ala Tyr Gly 
                 245                250                255
Ala Ser Ala Pro Ser Val Thr Ser Ala Ala Leu Arg Trp Met Tyr His 
             260                265                270
His Ser Gln Leu Gln Gly Ala His Gly Asp Ala Val Ile Leu Gly Met 
         275                280                285
Ser Ser Leu Glu Gln Leu Glu Gln Asn Leu Ala Ala Thr Glu Glu Gly 
     290                295                300
Pro Leu Glu Pro Ala Val Val Asp Ala Phe Asn Gln Ala Trp His Leu 
 305                310                315                320
Val Ala His Glu Cys Pro Asn Tyr Phe Arg 
                 325                330



<210> 5917
<211> 626
<212> DNA
<213> Rattus norvegicus
<308> AA892828
<400> 5917

actcatagg  aggaatccc  tttattcct  atcaaaaca  tttaacagc  aatgtagat  60
atatatgtt  tatttagac  tataagtta  cttccatgg  ggcattcta  cttgcccct  120
ctaatgaaa  agggcaaat  tttatatta  tcttattca  agactagac  aacttaaca  180
taacagaca  agagagcag  gcatctagg  tagggagta  aaaaattct  ctcataagc  240
catttaaac  tcttaccag  acagagaca  ctgctgcca  atcagcatt  ctcctgact  300
gtaagtctc  cagtacacg  caggggaag  cccaacacg  attttaaat  aatttcact  360
acttgacat  caacgtcta  attagatat  caaagtctt  tttattgca  atatgatgt  420
tttgacctg  ggtatggag  tgtcttcta  aatctttgc  taaggcata  ggacatcag  480
accagtgac  cgaacagca  gcgcatcaa  gaagttgaa  gcagggcct  ccataattc  540
cgcacaaat  tcagctcct  ctccaaatt  tggccagcc  ccttccaca  ttacgagat  600
atttgtctt  atgacactg  cttcta  626



<210> 5918
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> P49432
<400> 5918

Met Ala Gly Val Ala Gly Leu Val Arg Gly Leu Cys Gly Arg Leu Ser 
  1               5                  10                  15
Gly Leu Leu Lys Arg Leu Phe His Cys Ser Ala Pro Ala Ala Val Gln 
             20                  25                  30
Leu Thr Val Arg Glu Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
         35                  40                  45
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
     50                  55                  60
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
 65                  70                  75                  80
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                 85                  90                  95
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
             100                105                110
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
         115                120                125
Lys Thr Tyr Tyr Met Ser Ala Gly Leu Gln Pro Val Pro Ile Val Phe 
     130                135                140
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
 145                150                155                160
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                 165                170                175
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
             180                185                190
Asp Asp Asn Pro Val Val Met Leu Glu Asn Glu Leu Met Tyr Gly Val 
         195                200                205
Ala Phe Glu Leu Pro Thr Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
     210                215                220
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Asn Val Val 
 225                230                235                240
Cys Tyr Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                 245                250                255
Ser Lys Gly Gly Ile Glu Cys Glu Val Ile Asn Leu Arg Thr Ile Arg 
             260                265                270
Pro Met Asp Ile Glu Ala Ile Glu Ala Ser Val Met Lys Thr Asn His 
         275                280                285
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
     290                295                300
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
 305                310                315                320
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                 325                330                335
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
             340                345                350
Ile Lys Lys Thr Leu Asn Ile 
         355



<210> 5919
<211> 1095
<212> DNA
<213> Homo sapiens
<308> M34055
<400> 5919

ccaagatgg  ggcggtgtc  ggcttggtg  ggagacccc  tcgggaggt  tccgggctg  60
tgaagaggc  ctttcactg  accgcgccg  ctgccgtgc  ggtgacagt  cgtgatgct  120
taaatcagg  tatggatga  gagctggaa  gagatgaga  ggtatttct  cttggagaa  180
aagttgccc  gtatgatgg  gcatacaag  ttagtcgag  gctgtggaa  aaatatgga  240
acaagagga  tattgacac  cccatatca  agatgggct  tgctggaat  gctgtaggt  300
cagctatgg  tgggttgcg  cccatttgt  aatttatga  cttcaattt  tccatgcaa  360
ccattgacc  ggttataaa  tcagctgcc  agacctact  catgtctgg  ggccttcag  420
ctgtgccta  agtcttcag  ggacccaat  gtgcctcag  aggtgtagc  gcccagcac  480
cacagtgct  tgctgcctg  tatgggcac  gcccaggct  aaaggtggt  agtccctgg  540
attcagagg  tgctaaagg  cttattaaa  cagccattc  ggataacaa  ccagtggtg  600
tgctagaga  tgaattgat  tatggggtt  cttttgaat  tcctccgga  gctcagtca  660
aagattttc  gattcctat  ggaaaagcc  aaatagaaa  gcaaggaac  catataact  720
tggtttccc  ttcaagacc  gtgggccac  gcttagaag  tgcagcagt  ctatctaaa  780
aaggagttg  atgtgaggt  ataaatatg  gtaccatta  accaatgga  atggaaacc  840
tagaagcca  tgtcatgaa  acaaatcat  ttgtaactg  ggaaggagg  tggccacag  900
ttggagtag  agctgaaat  tgtgccagg  tcatggaag  tcctgcgtt  aatttcctg  960
atgctcctg  tgttcgtgt  actggtgct  atgtcccta  gccttatgc  aagattcta  1020
aggacaact  tatacctca  gtcaaagac  tcatatttg  aataaagaa  acattaaat  1080
tttagtttg  acttg  1095



<210> 5920
<211> 359
<212> PRT
<213> Homo sapiens
<308> P11177
<400> 5920

Met Ala Ala Val Ser Gly Leu Val Arg Arg Pro Leu Arg Glu Val Ser 
  1               5                  10                  15
Gly Leu Leu Lys Arg Arg Phe His Trp Thr Ala Pro Ala Ala Val Gln 
             20                  25                  30
Val Thr Val Arg Asp Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
         35                  40                  45
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
     50                  55                  60
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
 65                  70                  75                  80
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                 85                  90                  95
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
             100                105                110
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
         115                120                125
Lys Thr Tyr Tyr Met Ser Gly Gly Leu Gln Pro Val Pro Ile Val Phe 
     130                135                140
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
 145                150                155                160
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                 165                170                175
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
             180                185                190
Asp Asn Asn Pro Val Val Val Leu Glu Asn Glu Leu Met Tyr Gly Val 
         195                200                205
Pro Phe Glu Phe Pro Pro Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
     210                215                220
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Thr Val Val 
 225                230                235                240
Ser His Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                 245                250                255
Ser Lys Glu Gly Val Glu Cys Glu Val Ile Asn Met Arg Thr Ile Arg 
             260                265                270
Pro Met Asp Met Glu Thr Ile Glu Ala Ser Val Met Lys Thr Asn His 
         275                280                285
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
     290                295                300
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
 305                310                315                320
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                 325                330                335
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
             340                345                350
Ile Lys Lys Thr Leu Asn Ile 
         355



<210> 5921
<211> 626
<212> DNA
<213> Rattus norvegicus
<308> AA892828
<400> 5921

actcatagg  aggaatccc  tttattcct  atcaaaaca  tttaacagc  aatgtagat  60
atatatgtt  tatttagac  tataagtta  cttccatgg  ggcattcta  cttgcccct  120
ctaatgaaa  agggcaaat  tttatatta  tcttattca  agactagac  aacttaaca  180
taacagaca  agagagcag  gcatctagg  tagggagta  aaaaattct  ctcataagc  240
catttaaac  tcttaccag  acagagaca  ctgctgcca  atcagcatt  ctcctgact  300
gtaagtctc  cagtacacg  caggggaag  cccaacacg  attttaaat  aatttcact  360
acttgacat  caacgtcta  attagatat  caaagtctt  tttattgca  atatgatgt  420
tttgacctg  ggtatggag  tgtcttcta  aatctttgc  taaggcata  ggacatcag  480
accagtgac  cgaacagca  gcgcatcaa  gaagttgaa  gcagggcct  ccataattc  540
cgcacaaat  tcagctcct  ctccaaatt  tggccagcc  ccttccaca  ttacgagat  600
atttgtctt  atgacactg  cttcta  626



<210> 5922
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> P49432
<400> 5922

Met Ala Gly Val Ala Gly Leu Val Arg Gly Leu Cys Gly Arg Leu Ser 
  1               5                  10                  15
Gly Leu Leu Lys Arg Leu Phe His Cys Ser Ala Pro Ala Ala Val Gln 
             20                  25                  30
Leu Thr Val Arg Glu Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
         35                  40                  45
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
     50                  55                  60
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
 65                  70                  75                  80
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                 85                  90                  95
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
             100                105                110
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
         115                120                125
Lys Thr Tyr Tyr Met Ser Ala Gly Leu Gln Pro Val Pro Ile Val Phe 
     130                135                140
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
 145                150                155                160
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                 165                170                175
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
             180                185                190
Asp Asp Asn Pro Val Val Met Leu Glu Asn Glu Leu Met Tyr Gly Val 
         195                200                205
Ala Phe Glu Leu Pro Thr Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
     210                215                220
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Asn Val Val 
 225                230                235                240
Cys Tyr Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                 245                250                255
Ser Lys Gly Gly Ile Glu Cys Glu Val Ile Asn Leu Arg Thr Ile Arg 
             260                265                270
Pro Met Asp Ile Glu Ala Ile Glu Ala Ser Val Met Lys Thr Asn His 
         275                280                285
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
     290                295                300
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
 305                310                315                320
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                 325                330                335
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
             340                345                350
Ile Lys Lys Thr Leu Asn Ile 
         355



<210> 5923
<211> 1095
<212> DNA
<213> Homo sapiens
<308> M34055
<400> 5923

ccaagatgg  ggcggtgtc  ggcttggtg  ggagacccc  tcgggaggt  tccgggctg  60
tgaagaggc  ctttcactg  accgcgccg  ctgccgtgc  ggtgacagt  cgtgatgct  120
taaatcagg  tatggatga  gagctggaa  gagatgaga  ggtatttct  cttggagaa  180
aagttgccc  gtatgatgg  gcatacaag  ttagtcgag  gctgtggaa  aaatatgga  240
acaagagga  tattgacac  cccatatca  agatgggct  tgctggaat  gctgtaggt  300
cagctatgg  tgggttgcg  cccatttgt  aatttatga  cttcaattt  tccatgcaa  360
ccattgacc  ggttataaa  tcagctgcc  agacctact  catgtctgg  ggccttcag  420
ctgtgccta  agtcttcag  ggacccaat  gtgcctcag  aggtgtagc  gcccagcac  480
cacagtgct  tgctgcctg  tatgggcac  gcccaggct  aaaggtggt  agtccctgg  540
attcagagg  tgctaaagg  cttattaaa  cagccattc  ggataacaa  ccagtggtg  600
tgctagaga  tgaattgat  tatggggtt  cttttgaat  tcctccgga  gctcagtca  660
aagattttc  gattcctat  ggaaaagcc  aaatagaaa  gcaaggaac  catataact  720
tggtttccc  ttcaagacc  gtgggccac  gcttagaag  tgcagcagt  ctatctaaa  780
aaggagttg  atgtgaggt  ataaatatg  gtaccatta  accaatgga  atggaaacc  840
tagaagcca  tgtcatgaa  acaaatcat  ttgtaactg  ggaaggagg  tggccacag  900
ttggagtag  agctgaaat  tgtgccagg  tcatggaag  tcctgcgtt  aatttcctg  960
atgctcctg  tgttcgtgt  actggtgct  atgtcccta  gccttatgc  aagattcta  1020
aggacaact  tatacctca  gtcaaagac  tcatatttg  aataaagaa  acattaaat  1080
tttagtttg  acttg  1095



<210> 5924
<211> 359
<212> PRT
<213> Homo sapiens
<308> P11177
<400> 5924

Met Ala Ala Val Ser Gly Leu Val Arg Arg Pro Leu Arg Glu Val Ser 
  1               5                  10                  15
Gly Leu Leu Lys Arg Arg Phe His Trp Thr Ala Pro Ala Ala Val Gln 
             20                  25                  30
Val Thr Val Arg Asp Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
         35                  40                  45
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
     50                  55                  60
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
 65                  70                  75                  80
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                 85                  90                  95
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
             100                105                110
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
         115                120                125
Lys Thr Tyr Tyr Met Ser Gly Gly Leu Gln Pro Val Pro Ile Val Phe 
     130                135                140
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
 145                150                155                160
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                 165                170                175
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
             180                185                190
Asp Asn Asn Pro Val Val Val Leu Glu Asn Glu Leu Met Tyr Gly Val 
         195                200                205
Pro Phe Glu Phe Pro Pro Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
     210                215                220
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Thr Val Val 
 225                230                235                240
Ser His Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                 245                250                255
Ser Lys Glu Gly Val Glu Cys Glu Val Ile Asn Met Arg Thr Ile Arg 
             260                265                270
Pro Met Asp Met Glu Thr Ile Glu Ala Ser Val Met Lys Thr Asn His 
         275                280                285
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
     290                295                300
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
 305                310                315                320
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                 325                330                335
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
             340                345                350
Ile Lys Lys Thr Leu Asn Ile 
         355



<210> 5925
<211> 626
<212> DNA
<213> Rattus norvegicus
<308> AA892828
<400> 5925

actcatagg  aggaatccc  tttattcct  atcaaaaca  tttaacagc  aatgtagat  60
atatatgtt  tatttagac  tataagtta  cttccatgg  ggcattcta  cttgcccct  120
ctaatgaaa  agggcaaat  tttatatta  tcttattca  agactagac  aacttaaca  180
taacagaca  agagagcag  gcatctagg  tagggagta  aaaaattct  ctcataagc  240
catttaaac  tcttaccag  acagagaca  ctgctgcca  atcagcatt  ctcctgact  300
gtaagtctc  cagtacacg  caggggaag  cccaacacg  attttaaat  aatttcact  360
acttgacat  caacgtcta  attagatat  caaagtctt  tttattgca  atatgatgt  420
tttgacctg  ggtatggag  tgtcttcta  aatctttgc  taaggcata  ggacatcag  480
accagtgac  cgaacagca  gcgcatcaa  gaagttgaa  gcagggcct  ccataattc  540
cgcacaaat  tcagctcct  ctccaaatt  tggccagcc  ccttccaca  ttacgagat  600
atttgtctt  atgacactg  cttcta  626



<210> 5926
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> P49432
<400> 5926

Met Ala Gly Val Ala Gly Leu Val Arg Gly Leu Cys Gly Arg Leu Ser 
  1               5                  10                  15
Gly Leu Leu Lys Arg Leu Phe His Cys Ser Ala Pro Ala Ala Val Gln 
             20                  25                  30
Leu Thr Val Arg Glu Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
         35                  40                  45
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
     50                  55                  60
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
 65                  70                  75                  80
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                 85                  90                  95
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
             100                105                110
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
         115                120                125
Lys Thr Tyr Tyr Met Ser Ala Gly Leu Gln Pro Val Pro Ile Val Phe 
     130                135                140
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
 145                150                155                160
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                 165                170                175
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
             180                185                190
Asp Asp Asn Pro Val Val Met Leu Glu Asn Glu Leu Met Tyr Gly Val 
         195                200                205
Ala Phe Glu Leu Pro Thr Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
     210                215                220
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Asn Val Val 
 225                230                235                240
Cys Tyr Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                 245                250                255
Ser Lys Gly Gly Ile Glu Cys Glu Val Ile Asn Leu Arg Thr Ile Arg 
             260                265                270
Pro Met Asp Ile Glu Ala Ile Glu Ala Ser Val Met Lys Thr Asn His 
         275                280                285
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
     290                295                300
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
 305                310                315                320
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                 325                330                335
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
             340                345                350
Ile Lys Lys Thr Leu Asn Ile 
         355



<210> 5927
<211> 1095
<212> DNA
<213> Homo sapiens
<308> M34055
<400> 5927

ccaagatgg  ggcggtgtc  ggcttggtg  ggagacccc  tcgggaggt  tccgggctg  60
tgaagaggc  ctttcactg  accgcgccg  ctgccgtgc  ggtgacagt  cgtgatgct  120
taaatcagg  tatggatga  gagctggaa  gagatgaga  ggtatttct  cttggagaa  180
aagttgccc  gtatgatgg  gcatacaag  ttagtcgag  gctgtggaa  aaatatgga  240
acaagagga  tattgacac  cccatatca  agatgggct  tgctggaat  gctgtaggt  300
cagctatgg  tgggttgcg  cccatttgt  aatttatga  cttcaattt  tccatgcaa  360
ccattgacc  ggttataaa  tcagctgcc  agacctact  catgtctgg  ggccttcag  420
ctgtgccta  agtcttcag  ggacccaat  gtgcctcag  aggtgtagc  gcccagcac  480
cacagtgct  tgctgcctg  tatgggcac  gcccaggct  aaaggtggt  agtccctgg  540
attcagagg  tgctaaagg  cttattaaa  cagccattc  ggataacaa  ccagtggtg  600
tgctagaga  tgaattgat  tatggggtt  cttttgaat  tcctccgga  gctcagtca  660
aagattttc  gattcctat  ggaaaagcc  aaatagaaa  gcaaggaac  catataact  720
tggtttccc  ttcaagacc  gtgggccac  gcttagaag  tgcagcagt  ctatctaaa  780
aaggagttg  atgtgaggt  ataaatatg  gtaccatta  accaatgga  atggaaacc  840
tagaagcca  tgtcatgaa  acaaatcat  ttgtaactg  ggaaggagg  tggccacag  900
ttggagtag  agctgaaat  tgtgccagg  tcatggaag  tcctgcgtt  aatttcctg  960
atgctcctg  tgttcgtgt  actggtgct  atgtcccta  gccttatgc  aagattcta  1020
aggacaact  tatacctca  gtcaaagac  tcatatttg  aataaagaa  acattaaat  1080
tttagtttg  acttg  1095



<210> 5928
<211> 359
<212> PRT
<213> Homo sapiens
<308> P11177
<400> 5928

Met Ala Ala Val Ser Gly Leu Val Arg Arg Pro Leu Arg Glu Val Ser 
  1               5                  10                  15
Gly Leu Leu Lys Arg Arg Phe His Trp Thr Ala Pro Ala Ala Val Gln 
             20                  25                  30
Val Thr Val Arg Asp Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
         35                  40                  45
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
     50                  55                  60
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
 65                  70                  75                  80
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                 85                  90                  95
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
             100                105                110
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
         115                120                125
Lys Thr Tyr Tyr Met Ser Gly Gly Leu Gln Pro Val Pro Ile Val Phe 
     130                135                140
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
 145                150                155                160
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                 165                170                175
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
             180                185                190
Asp Asn Asn Pro Val Val Val Leu Glu Asn Glu Leu Met Tyr Gly Val 
         195                200                205
Pro Phe Glu Phe Pro Pro Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
     210                215                220
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Thr Val Val 
 225                230                235                240
Ser His Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                 245                250                255
Ser Lys Glu Gly Val Glu Cys Glu Val Ile Asn Met Arg Thr Ile Arg 
             260                265                270
Pro Met Asp Met Glu Thr Ile Glu Ala Ser Val Met Lys Thr Asn His 
         275                280                285
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
     290                295                300
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
 305                310                315                320
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                 325                330                335
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
             340                345                350
Ile Lys Lys Thr Leu Asn Ile 
         355



<210> 5929
<211> 626
<212> DNA
<213> Rattus norvegicus
<308> AA892828
<400> 5929

actcatagg  aggaatccc  tttattcct  atcaaaaca  tttaacagc  aatgtagat  60
atatatgtt  tatttagac  tataagtta  cttccatgg  ggcattcta  cttgcccct  120
ctaatgaaa  agggcaaat  tttatatta  tcttattca  agactagac  aacttaaca  180
taacagaca  agagagcag  gcatctagg  tagggagta  aaaaattct  ctcataagc  240
catttaaac  tcttaccag  acagagaca  ctgctgcca  atcagcatt  ctcctgact  300
gtaagtctc  cagtacacg  caggggaag  cccaacacg  attttaaat  aatttcact  360
acttgacat  caacgtcta  attagatat  caaagtctt  tttattgca  atatgatgt  420
tttgacctg  ggtatggag  tgtcttcta  aatctttgc  taaggcata  ggacatcag  480
accagtgac  cgaacagca  gcgcatcaa  gaagttgaa  gcagggcct  ccataattc  540
cgcacaaat  tcagctcct  ctccaaatt  tggccagcc  ccttccaca  ttacgagat  600
atttgtctt  atgacactg  cttcta  626



<210> 5930
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> P49432
<400> 5930

Met Ala Gly Val Ala Gly Leu Val Arg Gly Leu Cys Gly Arg Leu Ser 
  1               5                  10                  15
Gly Leu Leu Lys Arg Leu Phe His Cys Ser Ala Pro Ala Ala Val Gln 
             20                  25                  30
Leu Thr Val Arg Glu Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
         35                  40                  45
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
     50                  55                  60
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
 65                  70                  75                  80
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                 85                  90                  95
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
             100                105                110
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
         115                120                125
Lys Thr Tyr Tyr Met Ser Ala Gly Leu Gln Pro Val Pro Ile Val Phe 
     130                135                140
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
 145                150                155                160
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                 165                170                175
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
             180                185                190
Asp Asp Asn Pro Val Val Met Leu Glu Asn Glu Leu Met Tyr Gly Val 
         195                200                205
Ala Phe Glu Leu Pro Thr Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
     210                215                220
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Asn Val Val 
 225                230                235                240
Cys Tyr Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                 245                250                255
Ser Lys Gly Gly Ile Glu Cys Glu Val Ile Asn Leu Arg Thr Ile Arg 
             260                265                270
Pro Met Asp Ile Glu Ala Ile Glu Ala Ser Val Met Lys Thr Asn His 
         275                280                285
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
     290                295                300
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
 305                310                315                320
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                 325                330                335
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
             340                345                350
Ile Lys Lys Thr Leu Asn Ile 
         355



<210> 5931
<211> 1095
<212> DNA
<213> Homo sapiens
<308> M34055
<400> 5931

ccaagatgg  ggcggtgtc  ggcttggtg  ggagacccc  tcgggaggt  tccgggctg  60
tgaagaggc  ctttcactg  accgcgccg  ctgccgtgc  ggtgacagt  cgtgatgct  120
taaatcagg  tatggatga  gagctggaa  gagatgaga  ggtatttct  cttggagaa  180
aagttgccc  gtatgatgg  gcatacaag  ttagtcgag  gctgtggaa  aaatatgga  240
acaagagga  tattgacac  cccatatca  agatgggct  tgctggaat  gctgtaggt  300
cagctatgg  tgggttgcg  cccatttgt  aatttatga  cttcaattt  tccatgcaa  360
ccattgacc  ggttataaa  tcagctgcc  agacctact  catgtctgg  ggccttcag  420
ctgtgccta  agtcttcag  ggacccaat  gtgcctcag  aggtgtagc  gcccagcac  480
cacagtgct  tgctgcctg  tatgggcac  gcccaggct  aaaggtggt  agtccctgg  540
attcagagg  tgctaaagg  cttattaaa  cagccattc  ggataacaa  ccagtggtg  600
tgctagaga  tgaattgat  tatggggtt  cttttgaat  tcctccgga  gctcagtca  660
aagattttc  gattcctat  ggaaaagcc  aaatagaaa  gcaaggaac  catataact  720
tggtttccc  ttcaagacc  gtgggccac  gcttagaag  tgcagcagt  ctatctaaa  780
aaggagttg  atgtgaggt  ataaatatg  gtaccatta  accaatgga  atggaaacc  840
tagaagcca  tgtcatgaa  acaaatcat  ttgtaactg  ggaaggagg  tggccacag  900
ttggagtag  agctgaaat  tgtgccagg  tcatggaag  tcctgcgtt  aatttcctg  960
atgctcctg  tgttcgtgt  actggtgct  atgtcccta  gccttatgc  aagattcta  1020
aggacaact  tatacctca  gtcaaagac  tcatatttg  aataaagaa  acattaaat  1080
tttagtttg  acttg  1095



<210> 5932
<211> 359
<212> PRT
<213> Homo sapiens
<308> P11177
<400> 5932

Met Ala Ala Val Ser Gly Leu Val Arg Arg Pro Leu Arg Glu Val Ser 
  1               5                  10                  15
Gly Leu Leu Lys Arg Arg Phe His Trp Thr Ala Pro Ala Ala Val Gln 
             20                  25                  30
Val Thr Val Arg Asp Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
         35                  40                  45
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
     50                  55                  60
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
 65                  70                  75                  80
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                 85                  90                  95
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
             100                105                110
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
         115                120                125
Lys Thr Tyr Tyr Met Ser Gly Gly Leu Gln Pro Val Pro Ile Val Phe 
     130                135                140
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
 145                150                155                160
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                 165                170                175
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
             180                185                190
Asp Asn Asn Pro Val Val Val Leu Glu Asn Glu Leu Met Tyr Gly Val 
         195                200                205
Pro Phe Glu Phe Pro Pro Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
     210                215                220
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Thr Val Val 
 225                230                235                240
Ser His Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                 245                250                255
Ser Lys Glu Gly Val Glu Cys Glu Val Ile Asn Met Arg Thr Ile Arg 
             260                265                270
Pro Met Asp Met Glu Thr Ile Glu Ala Ser Val Met Lys Thr Asn His 
         275                280                285
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
     290                295                300
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
 305                310                315                320
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                 325                330                335
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
             340                345                350
Ile Lys Lys Thr Leu Asn Ile 
         355



<210> 5933
<211> 626
<212> DNA
<213> Rattus norvegicus
<308> AA892828
<400> 5933

actcatagg  aggaatccc  tttattcct  atcaaaaca  tttaacagc  aatgtagat  60
atatatgtt  tatttagac  tataagtta  cttccatgg  ggcattcta  cttgcccct  120
ctaatgaaa  agggcaaat  tttatatta  tcttattca  agactagac  aacttaaca  180
taacagaca  agagagcag  gcatctagg  tagggagta  aaaaattct  ctcataagc  240
catttaaac  tcttaccag  acagagaca  ctgctgcca  atcagcatt  ctcctgact  300
gtaagtctc  cagtacacg  caggggaag  cccaacacg  attttaaat  aatttcact  360
acttgacat  caacgtcta  attagatat  caaagtctt  tttattgca  atatgatgt  420
tttgacctg  ggtatggag  tgtcttcta  aatctttgc  taaggcata  ggacatcag  480
accagtgac  cgaacagca  gcgcatcaa  gaagttgaa  gcagggcct  ccataattc  540
cgcacaaat  tcagctcct  ctccaaatt  tggccagcc  ccttccaca  ttacgagat  600
atttgtctt  atgacactg  cttcta  626



<210> 5934
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> P49432
<400> 5934

Met Ala Gly Val Ala Gly Leu Val Arg Gly Leu Cys Gly Arg Leu Ser 
  1               5                  10                  15
Gly Leu Leu Lys Arg Leu Phe His Cys Ser Ala Pro Ala Ala Val Gln 
             20                  25                  30
Leu Thr Val Arg Glu Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
         35                  40                  45
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
     50                  55                  60
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
 65                  70                  75                  80
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                 85                  90                  95
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
             100                105                110
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
         115                120                125
Lys Thr Tyr Tyr Met Ser Ala Gly Leu Gln Pro Val Pro Ile Val Phe 
     130                135                140
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
 145                150                155                160
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                 165                170                175
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
             180                185                190
Asp Asp Asn Pro Val Val Met Leu Glu Asn Glu Leu Met Tyr Gly Val 
         195                200                205
Ala Phe Glu Leu Pro Thr Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
     210                215                220
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Asn Val Val 
 225                230                235                240
Cys Tyr Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                 245                250                255
Ser Lys Gly Gly Ile Glu Cys Glu Val Ile Asn Leu Arg Thr Ile Arg 
             260                265                270
Pro Met Asp Ile Glu Ala Ile Glu Ala Ser Val Met Lys Thr Asn His 
         275                280                285
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
     290                295                300
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
 305                310                315                320
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                 325                330                335
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
             340                345                350
Ile Lys Lys Thr Leu Asn Ile 
         355



<210> 5935
<211> 1095
<212> DNA
<213> Homo sapiens
<308> M34055
<400> 5935

ccaagatgg  ggcggtgtc  ggcttggtg  ggagacccc  tcgggaggt  tccgggctg  60
tgaagaggc  ctttcactg  accgcgccg  ctgccgtgc  ggtgacagt  cgtgatgct  120
taaatcagg  tatggatga  gagctggaa  gagatgaga  ggtatttct  cttggagaa  180
aagttgccc  gtatgatgg  gcatacaag  ttagtcgag  gctgtggaa  aaatatgga  240
acaagagga  tattgacac  cccatatca  agatgggct  tgctggaat  gctgtaggt  300
cagctatgg  tgggttgcg  cccatttgt  aatttatga  cttcaattt  tccatgcaa  360
ccattgacc  ggttataaa  tcagctgcc  agacctact  catgtctgg  ggccttcag  420
ctgtgccta  agtcttcag  ggacccaat  gtgcctcag  aggtgtagc  gcccagcac  480
cacagtgct  tgctgcctg  tatgggcac  gcccaggct  aaaggtggt  agtccctgg  540
attcagagg  tgctaaagg  cttattaaa  cagccattc  ggataacaa  ccagtggtg  600
tgctagaga  tgaattgat  tatggggtt  cttttgaat  tcctccgga  gctcagtca  660
aagattttc  gattcctat  ggaaaagcc  aaatagaaa  gcaaggaac  catataact  720
tggtttccc  ttcaagacc  gtgggccac  gcttagaag  tgcagcagt  ctatctaaa  780
aaggagttg  atgtgaggt  ataaatatg  gtaccatta  accaatgga  atggaaacc  840
tagaagcca  tgtcatgaa  acaaatcat  ttgtaactg  ggaaggagg  tggccacag  900
ttggagtag  agctgaaat  tgtgccagg  tcatggaag  tcctgcgtt  aatttcctg  960
atgctcctg  tgttcgtgt  actggtgct  atgtcccta  gccttatgc  aagattcta  1020
aggacaact  tatacctca  gtcaaagac  tcatatttg  aataaagaa  acattaaat  1080
tttagtttg  acttg  1095



<210> 5936
<211> 359
<212> PRT
<213> Homo sapiens
<308> P11177
<400> 5936

Met Ala Ala Val Ser Gly Leu Val Arg Arg Pro Leu Arg Glu Val Ser 
  1               5                  10                  15
Gly Leu Leu Lys Arg Arg Phe His Trp Thr Ala Pro Ala Ala Val Gln 
             20                  25                  30
Val Thr Val Arg Asp Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
         35                  40                  45
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
     50                  55                  60
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
 65                  70                  75                  80
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                 85                  90                  95
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
             100                105                110
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
         115                120                125
Lys Thr Tyr Tyr Met Ser Gly Gly Leu Gln Pro Val Pro Ile Val Phe 
     130                135                140
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
 145                150                155                160
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                 165                170                175
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
             180                185                190
Asp Asn Asn Pro Val Val Val Leu Glu Asn Glu Leu Met Tyr Gly Val 
         195                200                205
Pro Phe Glu Phe Pro Pro Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
     210                215                220
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Thr Val Val 
 225                230                235                240
Ser His Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                 245                250                255
Ser Lys Glu Gly Val Glu Cys Glu Val Ile Asn Met Arg Thr Ile Arg 
             260                265                270
Pro Met Asp Met Glu Thr Ile Glu Ala Ser Val Met Lys Thr Asn His 
         275                280                285
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
     290                295                300
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
 305                310                315                320
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                 325                330                335
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
             340                345                350
Ile Lys Lys Thr Leu Asn Ile 
         355



<210> 5937
<211> 626
<212> DNA
<213> Rattus norvegicus
<308> AA892828
<400> 5937

actcatagg  aggaatccc  tttattcct  atcaaaaca  tttaacagc  aatgtagat  60
atatatgtt  tatttagac  tataagtta  cttccatgg  ggcattcta  cttgcccct  120
ctaatgaaa  agggcaaat  tttatatta  tcttattca  agactagac  aacttaaca  180
taacagaca  agagagcag  gcatctagg  tagggagta  aaaaattct  ctcataagc  240
catttaaac  tcttaccag  acagagaca  ctgctgcca  atcagcatt  ctcctgact  300
gtaagtctc  cagtacacg  caggggaag  cccaacacg  attttaaat  aatttcact  360
acttgacat  caacgtcta  attagatat  caaagtctt  tttattgca  atatgatgt  420
tttgacctg  ggtatggag  tgtcttcta  aatctttgc  taaggcata  ggacatcag  480
accagtgac  cgaacagca  gcgcatcaa  gaagttgaa  gcagggcct  ccataattc  540
cgcacaaat  tcagctcct  ctccaaatt  tggccagcc  ccttccaca  ttacgagat  600
atttgtctt  atgacactg  cttcta  626



<210> 5938
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> P49432
<400> 5938

Met Ala Gly Val Ala Gly Leu Val Arg Gly Leu Cys Gly Arg Leu Ser 
  1               5                  10                  15
Gly Leu Leu Lys Arg Leu Phe His Cys Ser Ala Pro Ala Ala Val Gln 
             20                  25                  30
Leu Thr Val Arg Glu Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
         35                  40                  45
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
     50                  55                  60
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
 65                  70                  75                  80
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                 85                  90                  95
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
             100                105                110
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
         115                120                125
Lys Thr Tyr Tyr Met Ser Ala Gly Leu Gln Pro Val Pro Ile Val Phe 
     130                135                140
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
 145                150                155                160
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                 165                170                175
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
             180                185                190
Asp Asp Asn Pro Val Val Met Leu Glu Asn Glu Leu Met Tyr Gly Val 
         195                200                205
Ala Phe Glu Leu Pro Thr Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
     210                215                220
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Asn Val Val 
 225                230                235                240
Cys Tyr Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                 245                250                255
Ser Lys Gly Gly Ile Glu Cys Glu Val Ile Asn Leu Arg Thr Ile Arg 
             260                265                270
Pro Met Asp Ile Glu Ala Ile Glu Ala Ser Val Met Lys Thr Asn His 
         275                280                285
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
     290                295                300
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
 305                310                315                320
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                 325                330                335
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
             340                345                350
Ile Lys Lys Thr Leu Asn Ile 
         355



<210> 5939
<211> 1095
<212> DNA
<213> Homo sapiens
<308> M34055
<400> 5939

ccaagatgg  ggcggtgtc  ggcttggtg  ggagacccc  tcgggaggt  tccgggctg  60
tgaagaggc  ctttcactg  accgcgccg  ctgccgtgc  ggtgacagt  cgtgatgct  120
taaatcagg  tatggatga  gagctggaa  gagatgaga  ggtatttct  cttggagaa  180
aagttgccc  gtatgatgg  gcatacaag  ttagtcgag  gctgtggaa  aaatatgga  240
acaagagga  tattgacac  cccatatca  agatgggct  tgctggaat  gctgtaggt  300
cagctatgg  tgggttgcg  cccatttgt  aatttatga  cttcaattt  tccatgcaa  360
ccattgacc  ggttataaa  tcagctgcc  agacctact  catgtctgg  ggccttcag  420
ctgtgccta  agtcttcag  ggacccaat  gtgcctcag  aggtgtagc  gcccagcac  480
cacagtgct  tgctgcctg  tatgggcac  gcccaggct  aaaggtggt  agtccctgg  540
attcagagg  tgctaaagg  cttattaaa  cagccattc  ggataacaa  ccagtggtg  600
tgctagaga  tgaattgat  tatggggtt  cttttgaat  tcctccgga  gctcagtca  660
aagattttc  gattcctat  ggaaaagcc  aaatagaaa  gcaaggaac  catataact  720
tggtttccc  ttcaagacc  gtgggccac  gcttagaag  tgcagcagt  ctatctaaa  780
aaggagttg  atgtgaggt  ataaatatg  gtaccatta  accaatgga  atggaaacc  840
tagaagcca  tgtcatgaa  acaaatcat  ttgtaactg  ggaaggagg  tggccacag  900
ttggagtag  agctgaaat  tgtgccagg  tcatggaag  tcctgcgtt  aatttcctg  960
atgctcctg  tgttcgtgt  actggtgct  atgtcccta  gccttatgc  aagattcta  1020
aggacaact  tatacctca  gtcaaagac  tcatatttg  aataaagaa  acattaaat  1080
tttagtttg  acttg  1095



<210> 5940
<211> 359
<212> PRT
<213> Homo sapiens
<308> P11177
<400> 5940

Met Ala Ala Val Ser Gly Leu Val Arg Arg Pro Leu Arg Glu Val Ser 
  1               5                  10                  15
Gly Leu Leu Lys Arg Arg Phe His Trp Thr Ala Pro Ala Ala Val Gln 
             20                  25                  30
Val Thr Val Arg Asp Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
         35                  40                  45
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
     50                  55                  60
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
 65                  70                  75                  80
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                 85                  90                  95
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
             100                105                110
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
         115                120                125
Lys Thr Tyr Tyr Met Ser Gly Gly Leu Gln Pro Val Pro Ile Val Phe 
     130                135                140
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
 145                150                155                160
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                 165                170                175
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
             180                185                190
Asp Asn Asn Pro Val Val Val Leu Glu Asn Glu Leu Met Tyr Gly Val 
         195                200                205
Pro Phe Glu Phe Pro Pro Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
     210                215                220
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Thr Val Val 
 225                230                235                240
Ser His Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                 245                250                255
Ser Lys Glu Gly Val Glu Cys Glu Val Ile Asn Met Arg Thr Ile Arg 
             260                265                270
Pro Met Asp Met Glu Thr Ile Glu Ala Ser Val Met Lys Thr Asn His 
         275                280                285
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
     290                295                300
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
 305                310                315                320
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                 325                330                335
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
             340                345                350
Ile Lys Lys Thr Leu Asn Ile 
         355



<210> 5941
<211> 634
<212> DNA
<213> Rattus norvegicus
<308> AA892829
<400> 5941

tttttaagc  aaaaattaa  tttattgaa  caaggcatt  attcagcac  taacacaga  60
tgcaagaat  cctcagcat  taggggtac  gggagagag  gaacggttt  catttatga  120
gtaaaataa  aaaacctaa  cgctacaga  agtttgtaa  atttgtaaa  ctcctcgaa  180
aaggtctag  caactttac  gtttagtga  tttccccct  tcttaaagg  cgagaagct  240
gatgatgtg  gtattactg  ttataacta  taaatcagc  tggaaaatc  taagacaga  300
gcataaata  aatataaaa  ggcgagatt  ttaaaatcg  attataaga  tattaacaa  360
aagtggaaa  gatacatta  aaccagagc  gtgttacac  agttcaaaa  agaactcaa  420
ggcaaaaca  agctgatgc  catggaggg  aacggcctg  tttcaggaa  tgtgtccag  480
cagacaccc  cagagaagt  ctgtcagtg  ctgcgtggt  ccctgtgtt  ctcagccct  540
catccctgg  agagtgcct  gctcaggaa  ttaggcttt  tctaaggac  tgtagtact  600
caccagcac  gtccacgcc  tgggggcca  gaag  634



<210> 5942
<211> 624
<212> PRT
<213> Rattus norvegicus
<308> NP_035993
<400> 5942

Met Glu Ile Pro Gly Ser Leu Cys Lys Lys Val Lys Leu Ser Asn Asn 
  1               5                  10                  15
Ala Gln Asn Trp Gly Met Gln Arg Ala Thr Asn Val Thr Tyr Gln Ala 
             20                  25                  30
His His Val Ser Arg Asn Lys Arg Gly Gln Val Val Gly Thr Arg Gly 
         35                  40                  45
Gly Phe Arg Gly Cys Thr Val Trp Leu Thr Gly Leu Ser Gly Ala Gly 
     50                  55                  60
Lys Thr Thr Val Ser Met Ala Leu Glu Glu Tyr Leu Val Cys His Gly 
 65                  70                  75                  80
Ile Pro Cys Tyr Thr Leu Asp Gly Asp Asn Ile Arg Gln Gly Leu Asn 
                 85                  90                  95
Lys Asn Leu Gly Phe Ser Pro Glu Asp Arg Glu Glu Asn Val Arg Arg 
             100                105                110
Ile Ala Glu Val Ala Lys Leu Phe Ala Asp Ala Gly Leu Val Cys Ile 
         115                120                125
Thr Ser Phe Ile Ser Pro Tyr Thr Gln Asp Arg Asn Asn Ala Arg Gln 
     130                135                140
Ile His Glu Gly Ala Ser Leu Pro Phe Phe Glu Val Phe Val Asp Ala 
 145                150                155                160
Pro Leu His Val Cys Glu Gln Arg Asp Val Lys Gly Leu Tyr Lys Lys 
                 165                170                175
Ala Arg Ala Gly Glu Ile Lys Gly Phe Thr Gly Ile Asp Ser Glu Tyr 
             180                185                190
Glu Lys Pro Glu Ala Pro Glu Leu Val Leu Lys Thr Asp Ser Cys Asp 
         195                200                205
Val Asn Asp Cys Val Gln Gln Val Val Glu Leu Leu Gln Glu Arg Asp 
     210                215                220
Ile Val Pro Val Asp Ala Ser Tyr Glu Val Lys Glu Leu Tyr Val Pro 
 225                230                235                240
Glu Asn Lys Leu His Leu Ala Lys Thr Asp Ala Glu Ala Leu Pro Ala 
                 245                250                255
Leu Lys Ile Asn Lys Val Asp Met Gln Trp Val Gln Val Leu Ala Glu 
             260                265                270
Gly Trp Ala Thr Pro Leu Asn Gly Phe Met Arg Glu Arg Glu Tyr Leu 
         275                280                285
Gln Cys Leu His Phe Asp Cys Leu Leu Asp Gly Gly Val Ile Asn Leu 
     290                295                300
Ser Val Pro Ile Val Leu Thr Ala Thr His Glu Asp Lys Glu Arg Leu 
 305                310                315                320
Asp Gly Cys Thr Ala Phe Ala Leu Val Tyr Glu Gly Arg Arg Val Ala 
                 325                330                335
Ile Leu Arg Asn Pro Glu Phe Phe Glu His Arg Lys Glu Glu Arg Cys 
             340                345                350
Ala Arg Gln Trp Gly Thr Thr Cys Lys Asn His Pro Tyr Ile Lys Met 
         355                360                365
Val Leu Glu Gln Gly Asp Trp Leu Ile Gly Gly Asp Leu Gln Val Leu 
     370                375                380
Asp Arg Ile Tyr Trp Asn Asp Gly Leu Asp Gln Tyr Arg Leu Thr Pro 
 385                390                395                400
Thr Glu Leu Lys Gln Lys Phe Lys Asp Met Asn Ala Asp Ala Val Phe 
                 405                410                415
Ala Phe Gln Leu Arg Asn Pro Val His Asn Gly His Ala Leu Leu Met 
             420                425                430
Gln Asp Thr His Lys Gln Leu Leu Glu Arg Gly Tyr Arg Arg Pro Val 
         435                440                445
Leu Leu Leu His Pro Leu Gly Gly Trp Thr Lys Asp Asp Asp Val Pro 
     450                455                460
Leu Met Trp Arg Met Lys Gln His Ala Ala Val Leu Glu Glu Gly Ile 
 465                470                475                480
Leu Asp Pro Glu Thr Thr Val Val Ala Ile Phe Pro Ser Pro Met Met 
                 485                490                495
Tyr Ala Gly Pro Thr Glu Val Gln Trp His Cys Arg Ala Arg Met Val 
             500                505                510
Ala Gly Ala Asn Phe Tyr Ile Val Gly Arg Asp Pro Ala Gly Met Pro 
         515                520                525
His Pro Glu Thr Gly Lys Asp Leu Tyr Glu Pro Thr His Gly Ala Lys 
     530                535                540
Val Leu Thr Met Ala Pro Gly Leu Ile Thr Leu Glu Ile Val Pro Phe 
 545                550                555                560
Arg Val Ala Ala Tyr Asn Lys Lys Lys Lys Arg Met Asp Tyr Tyr Asp 
                 565                570                575
Ser Glu His His Glu Asp Phe Glu Phe Ile Ser Gly Thr Arg Met Arg 
             580                585                590
Lys Leu Ala Arg Glu Gly Gln Lys Pro Pro Glu Gly Phe Met Ala Pro 
         595                600                605
Lys Ala Trp Thr Val Leu Val Glu Tyr Tyr Lys Ser Leu Glu Lys Ala 
     610                615                620



<210> 5943
<211> 2511
<212> DNA
<213> Homo sapiens
<308> Y10387
<400> 5943

cgcagagaa  cccggctgc  cagcgcgct  cgggtcatg  agatccccg  gagcttgtg  60
aagaaagtc  agctgagca  taacgcgca  aactgggga  tgcagagag  aaccaatgt  120
acctaccaa  cccatcatg  cagcaggaa  aagagaggt  aggtggtgg  gaccagagg  180
ggctttcgt  gttgcacag  ttggctaac  ggcttgtct  gagcgggaa  gactactgt  240
agcatggcc  tggaggagt  cctggtttg  catggtatt  catgctaca  tctggatgg  300
gacaatatt  gtcaaggtc  caataaaaa  cttggcttt  gtcctgaag  cagagaaga  360
aatgttcga  gcatcgcag  agttgctaa  ctgtttgca  atgctggct  agtgtgcat  420
acaagtttc  tatcacctt  cactcagga  cgcaacaat  caaggcaaa  tcatgaagg  480
gcaagttta  cgttttttg  agtatttgt  gatgctcct  tgcatgttt  tgaacagag  540
gatgtcaaa  gactctaca  aaaagcccg  gcaggagaa  ttaaaggtt  cactgggat  600
gattctgaa  atgaaaagc  agaggcccc  gagttggtg  tgaaaacag  ctcctgtga  660
gtaaatgac  gtgtccagc  agttgtgga  cttctacag  aacgggata  tgtacctgt  720
gatgcatct  atgaagtaa  agaactata  gtgccagaa  ataaacttc  tttggcaaa  780
acagatgcg  aaacattac  agcactgaa  attaataaa  tggatatgc  gtgggtgca  840
gttttggca  aaggttggg  aaccccatt  aatggcttt  tgagagaga  ggagtactt  900
cagtgcctt  attttgatt  tcttctgga  ggaggtgtc  ttaacttgt  agtacctat  960
gttctgact  cgactcatg  agataaaga  aggctggac  gctgtacag  atttgctct  1020
atgtatgag  gccgccgtg  ggccattct  cgcaatcca  agttttttg  gcacaggaa  1080
gaggagcgc  gtgccagac  gtggggaac  acatgcaag  accacccct  tattaagat  1140
gtgatggaa  aaggagatt  gctgattgg  ggagatctt  aagtcttgg  tcgagttta  1200
tggaatgat  gtcttgatc  gtatcgtct  actcctact  agctaaagc  gaaatttaa  1260
gatatgaat  ctgatgctg  ctttgcatt  caactacgc  acccagtgc  caatggaca  1320
gccctgtta  tgcaggata  ccataagca  cttctagag  ggggctacc  gcgccctgt  1380
ctcctcctc  accctctgg  tgcttggac  aaggatgac  atgttcctt  gatgtggcg  1440
atgaagcag  atgctgcag  gttggagga  ggagttctg  atcctgaga  gacagtggt  1500
gccatcttc  catctccca  gatgtatgc  ggaccaact  aggtccagt  gcattgcag  1560
gcacggatg  ttgcaggag  caactttta  attgttgga  gagaccctg  tggcatgcc  1620
catccagaa  cagggaagg  tctttatga  ccaagtcat  gtgccaaag  gctgacgat  1680
gcccctggt  taatcactt  ggaaatagt  ccctttcga  ttgcagctt  caacaagaa  1740
aagaagcgt  tggactact  tgactctga  caccatgaa  actttgaat  tatttcagg  1800
acacgaatg  gcaaacttg  tcgagaagg  cagaaacca  ctgaaggtt  catggctcc  1860
aaggcttgg  ccgtgctga  agaatacta  aaatccttg  agaaagctt  ggctgttaa  1920
ccagtcact  cacctttga  acattacta  taacaagag  ggaccacat  gtctctgtt  1980
gcatttctt  gtggtgtct  tctggacat  cttcctaaa  acagaccat  ttccttaac  2040
tgcatcagt  ttggtctgc  ttatgagtt  tgttttgaa  aagtgtaac  cactgatgg  2100
tttaatgta  cttttccac  tattatagt  atattccta  aatacaatt  taaaattgt  2160
tttttatat  atatttatg  ttctgtgtc  tgatttttt  aagctgtta  attagttgt  2220
accagtagt  ttcacatta  atcttgctt  ttttcccct  aaaaaaaga  aaaaattac  2280
aaacaataa  cttggctag  ccttgtttt  aggatttta  aagaccttt  tagcgatta  2340
atttttttt  tacattgaa  atagaaact  cttcctttc  tctttccag  cagctattg  2400
tctttccag  tgttataat  taaagtatt  ttatgatct  tgtaagctc  gaatgaact  2460
ctttactca  taaaattaa  tttttggct  cttaaaaaa  aaaaaaaaa  a  2511



<210> 5944
<211> 624
<212> PRT
<213> Homo sapiens
<308> O43252
<400> 5944

Met Glu Ile Pro Gly Ser Leu Cys Lys Lys Val Lys Leu Ser Asn Asn 
  1               5                  10                  15
Ala Gln Asn Trp Gly Met Gln Arg Ala Thr Asn Val Thr Tyr Gln Ala 
             20                  25                  30
His His Val Ser Arg Asn Lys Arg Gly Gln Val Val Gly Thr Arg Gly 
         35                  40                  45
Gly Phe Arg Gly Cys Thr Val Trp Leu Thr Gly Leu Ser Gly Ala Gly 
     50                  55                  60
Lys Thr Thr Val Ser Met Ala Leu Glu Glu Tyr Leu Val Cys His Gly 
 65                  70                  75                  80
Ile Pro Cys Tyr Thr Leu Asp Gly Asp Asn Ile Arg Gln Gly Leu Asn 
                 85                  90                  95
Lys Asn Leu Gly Phe Ser Pro Glu Asp Arg Glu Glu Asn Val Arg Arg 
             100                105                110
Ile Ala Glu Val Ala Lys Leu Phe Ala Asp Ala Gly Leu Val Cys Ile 
         115                120                125
Thr Ser Phe Ile Ser Pro Tyr Thr Gln Asp Arg Asn Asn Ala Arg Gln 
     130                135                140
Ile His Glu Gly Ala Ser Leu Pro Phe Phe Glu Val Phe Val Asp Ala 
 145                150                155                160
Pro Leu His Val Cys Glu Gln Arg Asp Val Lys Gly Leu Tyr Lys Lys 
                 165                170                175
Ala Arg Ala Gly Glu Ile Lys Gly Phe Thr Gly Ile Asp Ser Glu Tyr 
             180                185                190
Glu Lys Pro Glu Ala Pro Glu Leu Val Leu Lys Thr Asp Ser Cys Asp 
         195                200                205
Val Asn Asp Cys Val Gln Gln Val Val Glu Leu Leu Gln Glu Arg Asp 
     210                215                220
Ile Val Pro Val Asp Ala Ser Tyr Glu Val Lys Glu Leu Tyr Val Pro 
 225                230                235                240
Glu Asn Lys Leu His Leu Ala Lys Thr Asp Ala Glu Thr Leu Pro Ala 
                 245                250                255
Leu Lys Ile Asn Lys Val Asp Met Gln Trp Val Gln Val Leu Ala Glu 
             260                265                270
Gly Trp Ala Thr Pro Leu Asn Gly Phe Met Arg Glu Arg Glu Tyr Leu 
         275                280                285
Gln Cys Leu His Phe Asp Cys Leu Leu Asp Gly Gly Val Ile Asn Leu 
     290                295                300
Ser Val Pro Ile Val Leu Thr Ala Thr His Glu Asp Lys Glu Arg Leu 
 305                310                315                320
Asp Gly Cys Thr Ala Phe Ala Leu Met Tyr Glu Gly Arg Arg Val Ala 
                 325                330                335
Ile Leu Arg Asn Pro Glu Phe Phe Glu His Arg Lys Glu Glu Arg Cys 
             340                345                350
Ala Arg Gln Trp Gly Thr Thr Cys Lys Asn His Pro Tyr Ile Lys Met 
         355                360                365
Val Met Glu Gln Gly Asp Trp Leu Ile Gly Gly Asp Leu Gln Val Leu 
     370                375                380
Asp Arg Val Tyr Trp Asn Asp Gly Leu Asp Gln Tyr Arg Leu Thr Pro 
 385                390                395                400
Thr Glu Leu Lys Gln Lys Phe Lys Asp Met Asn Ala Asp Ala Val Phe 
                 405                410                415
Ala Phe Gln Leu Arg Asn Pro Val His Asn Gly His Ala Leu Leu Met 
             420                425                430
Gln Asp Thr His Lys Gln Leu Leu Glu Arg Gly Tyr Arg Arg Pro Val 
         435                440                445
Leu Leu Leu His Pro Leu Gly Ala Trp Thr Lys Asp Asp Asp Val Pro 
     450                455                460
Leu Met Trp Arg Met Lys Gln His Ala Ala Val Leu Glu Glu Gly Val 
 465                470                475                480
Leu Asn Pro Glu Thr Thr Val Val Ala Ile Phe Pro Ser Pro Met Met 
                 485                490                495
Tyr Ala Gly Pro Thr Glu Val Gln Trp His Cys Arg Ala Arg Met Val 
             500                505                510
Ala Gly Ala Asn Phe Tyr Ile Val Gly Arg Asp Pro Ala Gly Met Pro 
         515                520                525
His Pro Glu Thr Gly Lys Asp Leu Tyr Glu Pro Ser His Gly Ala Lys 
     530                535                540
Val Leu Thr Met Ala Pro Gly Leu Ile Thr Leu Glu Ile Val Pro Phe 
 545                550                555                560
Arg Val Ala Ala Tyr Asn Lys Lys Lys Lys Arg Met Asp Tyr Tyr Asp 
                 565                570                575
Ser Glu His His Glu Asp Phe Glu Phe Ile Ser Gly Thr Arg Met Arg 
             580                585                590
Lys Leu Ala Arg Glu Gly Gln Lys Pro Pro Glu Gly Phe Met Ala Pro 
         595                600                605
Lys Ala Trp Thr Val Leu Thr Glu Tyr Tyr Lys Ser Leu Glu Lys Ala 
     610                615                620



<210> 5945
<211> 635
<212> DNA
<213> Rattus norvegicus
<308> AA892832
<400> 5945

ccgggtaat  aaaaaggtt  taatgatta  tgtttagac  ttatttgac  gtgtgggta  60
atccagatg  gctaagcac  ctttgacag  acactactg  atgttatag  tttgtacta  120
gatatgtaa  gaacctgcg  gcggtaccc  cggatggag  cacacatgg  cgctctaga  180
tagagaaga  caatgtaaa  agacgctgc  actccgtcc  aacagaggc  aatgaggac  240
aactggctc  ttagaatat  aatgtgcaa  attaaagca  ggtaaactg  tatttacat  300
aatatcaaa  ccacaatta  tttgtacat  gtcaattgt  ttctaggat  tgtcacgag  360
ggttcaatc  attttcttc  atgcagaag  tgttcaaag  ctaaacttt  aacacttta  420
agatgacac  tgtaacaat  gtccccact  gtatgacca  cgtctccag  gcactatct  480
ttactttta  acaagcgct  taaatcaat  tttagatgc  aagcagaaa  aaattacag  540
tgccaccga  atttacact  aataaagcg  ttgctcccc  aacacccag  tcctgcgtg  600
tccagctct  taattttgc  tcaaaatga  tacgg  635



<210> 5946
<211> 570
<212> DNA
<213> Rattus norvegicus
<308> AA892835
<400> 5946

gggggaagg  atacgatag  tataactgt  atccaatct  ctgtccact  tgtacacac  60
tacccacac  catacatat  catacacac  aaaagtccc  cccaaaaaa  aaaaaccac  120
ctcaacctg  accaatact  catattttg  ccaaaagaa  cgatcctgg  aagaagtgc  180
aaatgcaaa  tccaatgac  aagaaatgc  gataaaaca  catcattaa  atacaaaat  240
tttatatta  ggaactaat  acaggtgat  ttctccatg  ctgtaaaac  ttggaacaa  300
agagctgat  gttaaatct  gtccatgcc  gcttccaaa  cccagaaga  tttagttag  360
ttcattttt  gatgcttca  caaaatttt  tacaagatc  ggaacgtca  catcctctt  420
atcaatgtc  tctggtttg  gtgctttac  atccaatac  tgtcgtggg  actgttcag  480
taactttct  aggctcgtt  agctgtcag  accaagctg  cttagtatt  caggaagca  540
ttctgtgat  ggtttggct  ctgcatgacc  570



<210> 5948
<211> 544
<212> DNA
<213> Rattus norvegicus
<308> AA892842
<400> 5948

cacaatgtc  tatatttgc  atgctttca  agcccaaca  tgattttaa  aagaaatta  60
acaacatgc  ctcattgac  ttttaaaaa  ctatacaat  caagctaat  aaatagttt  120
ttatacata  taaacgtgg  gtttaaaaa  aaattccag  cccagatgt  tgcaggagt  180
tgtgagaaa  ggattccac  cgagcataa  cagaaaaac  actgaatga  accacaagt  240
caccaactc  tttatagta  atgccgacg  tcaccgagg  tcgaattcc  gtggtgtca  300
gagatatat  taacgtatt  cacacatgc  tacgatgca  aggaaaatg  aaaacaaaa  360
atgcagttg  ataccatgt  gactcccaa  ttttctaat  tacaacttg  taagaatga  420
aatatacag  gaaagtatt  taaaatagt  tatgattca  tgatgattt  ttttttact  480
aaataaata  caaattttg  cattttaat  tcacagtat  attcagttt  caatccaag  540
ggag  544



<210> 5949
<211> 2287
<212> DNA
<213> Homo sapiens
<308> U03851
<400> 5949

gaattcggc  cgagcggat  tggaggagc  gttgtctga  gaagagaag  tgcgtatag  60
agcaaaatt  atcattcat  cccctcctg  agaatttaa  gaggttttc  atgatgttc  120
gttactgct  aataatgac  atcttctca  ggaaggagc  gcccatgca  ttgcacagt  180
taacttgga  cagtttact  cagtaaaaa  tgaaggtta  gaagatcag  tattgataa  240
agaacatgg  gacttggga  atggaaagt  tttggatcc  aagaacaga  tctgtttta  300
atttgatca  ttaaggaag  aggcaactg  tccaagacc  tgtgaagta  aaaatgcag  360
tgaatcatg  agaacttca  tagaaactg  tctgagagc  tacgtaaaa  aacattacc  420
gaatggagt  tgcactgtg  atggcaaaa  aatagatgg  cagcaaacc  ttattgcat  480
catagaaag  catcagttc  aagcaaaaa  tttttggaa  ggtcgttgg  ggtcagaat  540
gaagtttac  atcactcct  caaccactc  agtggttgg  atcttgaaa  ttcaggttc  600
ttattatga  gatggtaat  ttcagctag  gagtcataa  gatatacaa  attccctaa  660
agtgtctaa  gaagtgcaa  cagcaaaag  atttataaa  attgtagaa  ctgcagaaa  720
tgaatacca  actgccatc  gtgagaatt  tcagacaat  tcggacact  ctttcaaag  780
cttacgtcg  cagttgcca  ttacacgca  taagattga  tggaacaag  tccttagct  840
caagattgg  aaagagatg  agaatgcat  agatgaaca  tgcatgacc  gatcatttt  900
gtgtctttg  gttaaaaaa  cattgcaaa  gtattctga  ctgtcaagc  gcccagtca  960
atgggctgt  gcatttaaa  tcactgtaa  taattagtt  gattagagc  caaagctta  1020
ctaatcaac  attattttc  ttttgtttg  tctaagagg  ttgaaaatc  gtttagttt  1080
aatgtcttt  tggttaggc  tttctttct  acaatgaag  gatgattct  ctagtttat  1140
gttaaaagt  tttgaagtg  ctcaaaaat  ttttactaa  tgtaaccct  aaattgatg  1200
cttttggtt  atgaaatca  taatttttg  tatttcccc  gttcttttt  atggggtca  1260
taatggaca  tctagttta  ggtggttga  ggatttagc  atatatgct  ctaaagaaa  1320
tgtctacct  ttcttcctc  cctgttcca  ttatgtaaa  ttgagatta  agggaaagc  1380
ttttctata  caattgtgt  taaaccttt  aagaaggtt  tttagctag  ttagtgttg  1440
actaaattt  ttttaaaca  ggcaaggtc  aatgctgtt  tgagattct  aaattaatg  1500
aaatactta  ttcagaaat  catttaatg  tttttttct  gtgacagtt  cgcaaatca  1560
cttgaattc  atatgtccc  gagttattt  tatcataaa  ccacaaatg  attataaca  1620
ggcaaattg  aatatatat  atcctgaac  catgaccat  tctcagttt  ttttttttt  1680
tcttggatt  aaaagtact  aaattcaat  tgacattaa  atgcaaatt  tcctattta  1740
ttgagtaga  aatcactta  cagtgagca  atatatttt  aaatacttt  tttggatat  1800
gtaattctt  actggttgt  aattagaaa  gctgggatt  catatggtg  gcggttaca  1860
tctaaattt  ttcatcctc  tatgcatca  aagcatgtt  gtaatattt  caaaaatag  1920
tctactgat  ctacaggaa  ttcaagcct  tggtgaatg  tagtattta  catagggag  1980
gaagtggag  tatggtttc  ttcaataga  tattgctga  tatacttga  tggaatcct  2040
tcctcacgt  ctcccacag  cgtctgggc  tggaaattt  ttttttatt  tattttatt  2100
ttttttttt  tagaaaaac  ccactttta  tatgtacaa  aaaatattt  attagcttg  2160
attgtatag  tttttaaaa  ttcaatgaa  gcatgttgt  taatttctt  ttaaaaatc  2220
ctgttgggc  ttgaaagca  tgagaatat  atatgaaat  atgaaaaaa  aaaaaaaaa  2280
actcgag  2287



<210> 5950
<211> 286
<212> PRT
<213> Homo sapiens
<308> P47755
<400> 5950

Met Ala Asp Leu Glu Glu Gln Leu Ser Asp Glu Glu Lys Val Arg Ile 
  1               5                  10                  15
Ala Ala Lys Phe Ile Ile His Ala Pro Pro Gly Glu Phe Asn Glu Val 
             20                  25                  30
Phe Asn Asp Val Arg Leu Leu Leu Asn Asn Asp Asn Leu Leu Arg Glu 
         35                  40                  45
Gly Ala Ala His Ala Phe Ala Gln Tyr Asn Leu Asp Gln Phe Thr Pro 
     50                  55                  60
Val Lys Ile Glu Gly Tyr Glu Asp Gln Val Leu Ile Thr Glu His Gly 
 65                  70                  75                  80
Asp Leu Gly Asn Gly Lys Phe Leu Asp Pro Lys Asn Arg Ile Cys Phe 
                 85                  90                  95
Lys Phe Asp His Leu Arg Lys Glu Ala Thr Asp Pro Arg Pro Cys Glu 
             100                105                110
Val Glu Asn Ala Val Glu Ser Trp Arg Thr Ser Val Glu Thr Ala Leu 
         115                120                125
Arg Ala Tyr Val Lys Glu His Tyr Pro Asn Gly Val Cys Thr Val Tyr 
     130                135                140
Gly Lys Lys Ile Asp Gly Gln Gln Thr Ile Ile Ala Cys Ile Glu Ser 
 145                150                155                160
His Gln Phe Gln Ala Lys Asn Phe Trp Asn Gly Arg Trp Arg Ser Glu 
                 165                170                175
Trp Lys Phe Thr Ile Thr Pro Ser Thr Thr Gln Val Val Gly Ile Leu 
             180                185                190
Lys Ile Gln Val His Tyr Tyr Glu Asp Gly Asn Val Gln Leu Val Ser 
         195                200                205
His Lys Asp Ile Gln Asp Ser Leu Thr Val Ser Asn Glu Val Gln Thr 
     210                215                220
Ala Lys Glu Phe Ile Lys Ile Val Glu Ala Ala Glu Asn Glu Tyr Gln 
 225                230                235                240
Thr Ala Ile Ser Glu Asn Tyr Gln Thr Met Ser Asp Thr Thr Phe Lys 
                 245                250                255
Ala Leu Arg Arg Gln Leu Pro Val Thr Arg Thr Lys Ile Asp Trp Asn 
             260                265                270
Lys Ile Leu Ser Tyr Lys Ile Gly Lys Glu Met Gln Asn Ala 
         275                280                285



<210> 5952
<211> 951
<212> DNA
<213> Homo sapiens
<308> AK024570
<400> 5952

atgtgctga  aatccgaag  gccgcggaa  gtggaggtg  gggccgccc  ccctagagg  660
gcccgtccg  gaggcagag  tgacaagga  ggtttcgag  gttttgctg  caaagggat  720
tcttacaac  tccaggcat  cgtctttct  ccctgctgg  cttggcatc  aaggtcact  780
tgccccccc  ttaccgcta  gggatgagc  ccccaggct  tgttgcaga  aagaggaag  840
accccccat  gatcaggcg  cgcccagtg  ttgtggaac  catctctga  gaagactgg  900
atctgttct  tggggacac  gtggagatc  tagaaggca  ggatgccgg  a  951



<210> 5953
<211> 217
<212> PRT
<213> Homo sapiens
<308> AK024570
<400> 5953

Met Arg Leu Ser Ala Leu Leu Ala Leu Ala Ser Lys Val Thr Leu Pro 
  1               5                  10                  15
Pro His Tyr Arg Tyr Gly Met Ser Pro Pro Gly Ser Val Ala Asp Lys 
             20                  25                  30
Arg Lys Asn Pro Pro Trp Ile Arg Arg Arg Pro Val Val Val Glu Pro 
         35                  40                  45
Ile Ser Asp Glu Asp Trp Tyr Leu Phe Cys Gly Asp Thr Val Glu Ile 
     50                  55                  60
Leu Glu Gly Lys Asp Ala Gly Lys Gln Gly Lys Val Val Gln Val Ile 
 65                  70                  75                  80
Arg Gln Arg Asn Trp Val Val Val Gly Gly Leu Asn Thr His Tyr Arg 
                 85                  90                  95
Tyr Ile Gly Lys Thr Met Asp Tyr Arg Gly Thr Met Val Pro Ser Glu 
             100                105                110
Ala Pro Leu Leu His Arg His Val Lys Leu Val Asp Pro Met Asp Arg 
         115                120                125
Lys Pro Thr Glu Ile Asp Trp Arg Phe Thr Glu Ala Gly Gln Arg Val 
     130                135                140
Arg Val Ser Thr Arg Ser Gly Arg Ile Ile Pro Lys Pro Glu Phe Pro 
 145                150                155                160
Arg Ala Asp Gly Ile Val Pro Glu Thr Trp Ile Asp Gly Pro Lys Asp 
                 165                170                175
Thr Ser Val Glu Asp Ala Leu Glu Arg Thr Tyr Val Pro Cys Leu Lys 
             180                185                190
Thr Leu Gln Glu Glu Val Met Glu Ala Met Gly Ile Lys Glu Thr Arg 
         195                200                205
Lys Tyr Lys Lys Val Tyr Trp Tyr Ter 
     210                215



<210> 5954
<211> 537
<212> DNA
<213> Rattus norvegicus
<308> AA892847
<400> 5954

ccggagctg  ggaccgaac  cagggcctt  cgcttccta  gcaagcgct  taccactga  60
ctaaatccc  aacccccct  aagtctcta  tcttaattt  aaaaatccc  aatcctgat  120
tctgagtca  caaagtcag  ggctggagt  caatgggca  cagggccct  cccgagggg  180
ctcaggaga  tggcccagt  gttcagcga  atctgcaga  ctgtgtggg  acagaggcc  240
aaaggccac  ggaaactgc  ccaagagtt  caagtttcc  agggggccc  tgcctcagc  300
gggcatggc  tggattctg  ccctgcaaa  gcactttgg  catgatggc  ggcacattc  360
caagtagcc  ggggaggca  ggccctgcc  tgcccttgg  gtgccaagg  tccgtggtc  420
aggcccagt  gagctgccg  aacctgtca  tcttgggtc  tcacaactg  gacatcatt  480
tgtatatcc  caagccctt  acgggatat  ggtaccaca  cacaacccc  gaagggt  537



<210> 5955
<211> 415
<212> PRT
<213> Rattus norvegicus
<308> CAA11703
<400> 5955

Met Leu Gln Lys Thr Val Leu Leu Leu Ala Leu Val Ala Gln Val Leu 
  1               5                  10                  15
Met Leu Glu Asn Gly Leu Leu Arg Thr Pro Pro Met Gly Trp Leu Ala 
             20                  25                  30
Trp Glu Arg Phe Arg Cys Asn Ile Asp Cys Val Glu Asp Pro Lys Asn 
         35                  40                  45
Cys Ile Ser Asp Gly Leu Phe Met Glu Met Ala Asp Arg Leu Ala Gln 
     50                  55                  60
Asp Gly Trp Arg Asp Leu Gly Tyr Val Tyr Leu Asn Ile Asp Asp Cys 
 65                  70                  75                  80
Trp Ile Gly Gly Arg Asp Ala Ser Gly Arg Leu Ile Pro Asp Pro Lys 
                 85                  90                  95
Arg Phe Pro His Gly Ile Ala Phe Leu Ala Asp Tyr Ala His Ser Leu 
             100                105                110
Gly Leu Lys Leu Gly Ile Tyr Glu Asp Met Gly Lys Met Thr Cys Met 
         115                120                125
Gly Tyr Pro Gly Thr Thr Leu Asp Lys Val Glu Leu Asp Ala Glu Thr 
     130                135                140
Phe Ala Glu Trp Lys Val Asp Met Leu Lys Leu Asp Gly Cys Phe Ser 
 145                150                155                160
Ser Ser Arg Glu Arg Ala Glu Gly Tyr Pro Lys Met Ala Ala Ala Leu 
                 165                170                175
Asn Ala Thr Gly Arg Pro Ile Ala Phe Ser Cys Ser Trp Pro Ala Tyr 
             180                185                190
Glu Gly Gly Leu Pro Pro Lys Val Asn Tyr Thr Glu Val Ser Arg Val 
         195                200                205
Cys Asn Leu Trp Arg Asn Tyr Lys Asp Ile Gln Asp Ser Trp Lys Ser 
     210                215                220
Val Leu Ser Ile Leu Asp Trp Phe Val Arg His Gln Asp Val Leu Gln 
 225                230                235                240
Pro Val Ala Gly Pro Gly His Trp Asn Asp Pro Asp Met Leu Leu Ile 
                 245                250                255
Gly Asn Phe Gly Leu Ser Phe Asp Glu Ser Arg Ala Gln Met Ala Leu 
             260                265                270
Trp Thr Val Leu Ala Ala Pro Leu Leu Met Ser Thr Asp Leu Arg Thr 
         275                280                285
Ile Ser Pro Gln Asn Met Asp Ile Leu Gln Asn Pro Leu Met Ile Lys 
     290                295                300
Ile Asn Gln Asp Pro Leu Gly Ile Gln Gly Arg Arg Ile Leu Lys Ser 
 305                310                315                320
Lys Ser His Ile Glu Val Phe Lys Arg Tyr Leu Ser Asn Gln Ala Ser 
                 325                330                335
Ala Leu Val Phe Phe Ser Arg Arg Thr Asp Met Pro Phe Arg Phe His 
             340                345                350
Cys Ser Leu Leu Glu Leu Asn Tyr Pro Lys Gly Arg Val Tyr Glu Gly 
         355                360                365
Gln Asn Val Phe Thr Gly Asp Ile Phe Ser Gly Leu Gln Thr Glu Val 
     370                375                380
Asn Phe Thr Val Ile Ile Asn Pro Ser Gly Val Val Met Trp Tyr Leu 
 385                390                395                400
Tyr Pro Ile Lys Asp Leu Gly Ile Ser Thr Met Met Ser His Trp 
                 405                410                415



<210> 5956
<211> 3598
<212> DNA
<213> Homo sapiens
<308> NM_000262
<400> 5956

cgcttcggt  gcataagtg  ggtgggagg  ggctctgcg  ttttgggga  ccagggcgg  60
aacccggac  cggctggaa  tccggagcc  gccgcagcc  cgcccctcc  ctctttctt  120
gtgacctta  gccagtggc  gcctttttc  gagcccggg  ggggccgaa  gcgcccgta  180
gccctcggg  ctcccagca  tgcagaggg  gtgaggtct  acatccaag  cacgttgtt  240
cgtatttct  aaggaagaa  tcaagctcc  ggaagtgat  gctggggat  gggcgggca  300
cttggggac  gagtgtacg  tccacgcct  aggttgagg  cggccgagc  agccaggca  360
ccgtgaccc  agtgctttt  agacgtttc  tagcttcca  agcccaaca  atacagctg  420
tacacgcag  ccagatctg  tcaggtcct  ggaagctga  tccagagcg  tgctgctga  480
gacagtgct  ttgctggga  atgtggccc  ggtgctgat  ctggacaat  ggctcctgc  540
gacaccacc  atgggctgg  tggcctggg  acgcttccg  tgcaacatt  actgtgatg  600
ggacccaaa  aactgcata  gtgaacagc  cttcatgga  atggctgac  ggatggcac  660
ggatggatg  cgggacatg  gctacacat  cctaaacat  gatgactgc  ggatcggcg  720
tcgcgatgc  agtggccgc  tgatgccag  tcccaagcg  ttccctcat  gcattcctt  780
cctggctga  tacgttcac  ccctgggcc  gaagttggg  atctacgcg  acatgggca  840
cttcacctg  atgggttac  caggcacca  actggacaa  gtggtccag  atgctcaga  900
cttcgccga  tggaaggta  acatgctca  gctggatgg  tgcttctcc  cccccgagg  960
gcgggccca  gggtacccc  agatggctg  tgccctgaa  gccacaggc  gccccatcg  1020
cttctcctg  agctggcca  cctatgaag  cggcctccc  ccaagggtg  actacagtc  1080
gctggcgga  atctgcaac  tctggcgta  ctatgatga  atccaggac  cctggtgga  1140
cgtgctctc  atcctgaat  ggttcgtgg  gcaccagga  atactgcag  cagtggccg  1200
ccctgggca  tggaatgac  ctgacatgc  gctcattgg  aactttggt  tcagcttag  1260
gcaatcccg  gcccagatg  ccctgtgga  ggtgctggc  gcccccctc  tgatgtcca  1320
agacctgcg  accatctcc  cccagaaca  ggacattct  cagaatcca  tcatgatca  1380
aatcaacca  gatccctta  gcatccagg  acgcaggat  cacaaggaa  aatctctca  1440
cgaagtgta  atgcggcct  tgtccaaca  ggctagcgc  ttagtcttc  tcagctgca  1500
gaccgatat  ccttatcgc  accactcct  ccttggcca  ctgaacttc  ccgggtctg  1560
gatatatga  gcccaggac  tctactcag  tgacatcat  agtggcctc  gagatgaaa  1620
caacttcac  gtgatcatc  acccttcag  ggtagtgat  tggtacctg  atcccatca  1680
gaacctgga  atgtcccag  agtgaggag  tgggacatg  gacaggctg  ggtggcacc  1740
ctgagccta  accatggag  cttggcatg  ccagggcaa  tggggaggt  ctctgctcc  1800
caggcctgc  cggtgactg  ccccatcat  cccaaagtg  aatctcacg  ccaggttct  1860
tgccctgtc  aagcgtaaa  cctcttgga  acttctttt  gggcaattt  cctgtggcc  1920
tcctggcct  tacttccat  tgcgcagcc  cacagacgt  gctgagcaa  tcgccagcc  1980
cctgagctc  atgcccatc  ggactctag  ctctgacct  gctgttgac  ctgaaatca  2040
gatttggaa  ttttcgaat  aggagtaga  agatctgac  tcttgccag  aatgcccat  2100
gatcatgtg  ttggctttt  tacccatag  gggccttgc  gcctgatac  actgggagt  2160
agggtcaca  aggagacct  ggctccctc  ggtcaccaa  aaacctgtt  tttaatcaa  2220
tagttgtaa  atggacctg  ggtaccttt  gttagggac  ctggtggca  tacacgggg  2280
gctggattc  aatctcacc  ctatggatg  tgtctggca  cgtctggcc  ctccttttc  2340
aaagtgacc  gaagattgt  cttcctaga  atgccagac  tgcctcaca  ccaggagct  2400
cccctgctg  gcctggtat  ctggcagtg  tgatggtga  aacacaatg  ggccaagta  2460
caatgctcc  aggtcctgc  gcttgtgct  tgcccagca  tcccctggc  agcacctca  2520
cctgctctt  tctctggtg  ctccacccc  acccctact  cttttcctt  atttctctc  2580
caacctggc  gcaaaggag  ttcatatcc  cagatgtgt  cacaaacct  tccaggagt  2640
gtgtcttaa  attgatttc  tgtccctct  cctaaggac  ggggtaaca  tcaaagtga  2700
ggaatgatg  gttcttgcc  gtcttgctt  ggtccgtat  tcccaagcc  tcctctttt  2760
gccaaggct  cagggcact  gtcttccct  gtggctctc  cctttggag  gagctagtg  2820
cagagaacc  agctaggtc  ccttgggct  tgaatgcag  agcacccag  gccccaggc  2880
ttgcactgt  ctgcccaag  agtattttc  gggtggatc  cccatactc  tcagggttc  2940
gaggtcctt  tatttaggg  atggtgtaa  aacttacat  tgcacattt  gttacatca  3000
ttaagatga  tgaagcttt  ctggttaag  acagggtca  cagagaaag  tcctttccc  3060
agttgatgt  ttgaggctg  tgagaaact  aggacagaa  cctacctca  cccaggcct  3120
cccctccgt  catagctct  cctttgggt  ttgttcata  tgctgttca  gcaaaatgg  3180
atagtctca  gagggaaca  cttctcttg  tagctccag  aaggctttg  gggaaatga  3240
ttgagacca  ggacttggg  gttgggggc  agagttgag  ctggacttg  ccaattaat  3300
cccttacct  tcagcccaa  atagctaca  gtctttact  gctgtataa  ttttccttt  3360
gtcctgggg  tgcctgatt  atcctatct  ttcaccctt  attctttca  caaacatgc  3420
atctatctc  caggacatt  attcccttc  attcaaggc  agttaggaa  gcaattatt  3480
tttttttca  ttaaataca  acttgtttg  acgcaaggt  ccctttctc  ttttaaaaa  3540
tttttatca  gaaaacttt  aaatacaaa  ataaaatgg  agagagtga  cctccatg  3598



<210> 5957
<211> 411
<212> PRT
<213> Homo sapiens
<308> P17050
<400> 5957

Met Leu Leu Lys Thr Val Leu Leu Leu Gly His Val Ala Gln Val Leu 
  1               5                  10                  15
Met Leu Asp Asn Gly Leu Leu Gln Thr Pro Pro Met Gly Trp Leu Ala 
             20                  25                  30
Trp Glu Arg Phe Arg Cys Asn Ile Asn Cys Asp Glu Asp Pro Lys Asn 
         35                  40                  45
Cys Ile Ser Glu Gln Leu Phe Met Glu Met Ala Asp Arg Met Ala Gln 
     50                  55                  60
Asp Gly Trp Arg Asp Met Gly Tyr Thr Tyr Leu Asn Ile Asp Asp Cys 
 65                  70                  75                  80
Trp Ile Gly Gly Arg Asp Ala Ser Gly Arg Leu Met Pro Asp Pro Lys 
                 85                  90                  95
Arg Phe Pro His Gly Ile Pro Phe Leu Ala Asp Tyr Val His Ser Leu 
             100                105                110
Gly Leu Lys Leu Gly Ile Tyr Ala Asp Met Gly Asn Phe Thr Cys Met 
         115                120                125
Gly Tyr Pro Gly Thr Thr Leu Asp Lys Val Val Gln Asp Ala Gln Thr 
     130                135                140
Phe Ala Glu Trp Lys Val Asp Met Leu Lys Leu Asp Gly Cys Phe Ser 
 145                150                155                160
Thr Pro Glu Glu Arg Ala Gln Gly Tyr Pro Lys Met Ala Ala Ala Leu 
                 165                170                175
Asn Ala Thr Gly Arg Pro Ile Ala Phe Ser Cys Ser Trp Pro Ala Tyr 
             180                185                190
Glu Gly Gly Leu Pro Pro Arg Val Asn Tyr Ser Leu Leu Ala Asp Ile 
         195                200                205
Cys Asn Leu Trp Arg Asn Tyr Asp Asp Ile Gln Asp Ser Trp Trp Ser 
     210                215                220
Val Leu Ser Ile Leu Asn Trp Phe Val Glu His Gln Asp Ile Leu Gln 
 225                230                235                240
Pro Val Ala Gly Pro Gly His Trp Asn Asp Pro Asp Met Leu Leu Ile 
                 245                250                255
Gly Asn Phe Gly Leu Ser Leu Glu Gln Ser Arg Ala Gln Met Ala Leu 
             260                265                270
Trp Thr Val Leu Ala Ala Pro Leu Leu Met Ser Thr Asp Leu Arg Thr 
         275                280                285
Ile Ser Ala Gln Asn Met Asp Ile Leu Gln Asn Pro Leu Met Ile Lys 
     290                295                300
Ile Asn Gln Asp Pro Leu Gly Ile Gln Gly Arg Arg Ile His Lys Glu 
 305                310                315                320
Lys Ser Leu Ile Glu Val Tyr Met Arg Pro Leu Ser Asn Lys Ala Ser 
                 325                330                335
Ala Leu Val Phe Phe Ser Cys Arg Thr Asp Met Pro Tyr Arg Tyr His 
             340                345                350
Ser Ser Leu Gly Gln Leu Asn Phe Thr Gly Ser Val Ile Tyr Glu Ala 
         355                360                365
Gln Asp Val Tyr Ser Gly Asp Ile Ile Ser Gly Leu Arg Asp Glu Thr 
     370                375                380
Asn Phe Thr Val Ile Ile Asn Pro Ser Gly Val Val Met Trp Tyr Leu 
 385                390                395                400
Tyr Pro Ile Lys Asn Leu Glu Met Ser Gln Gln 
                 405                410



<210> 5958
<211> 593
<212> DNA
<213> Rattus norvegicus
<308> AA892849
<400> 5958

agaaatgat  tttaatact  ctggaatga  taggaatct  agaacagat  gtgggtggc  60
accctgggc  ccaggatgt  agagcctga  cctgcttcc  tgcatgggg  cttgccctg  120
ggagaaggg  caggcaact  gagtcctga  cgaagggtg  gcaggcaga  gcaggcaga  180
caggcagca  ctgtagctt  gagaatggc  cagcagtag  cccatgatg  ggctggctt  240
agtcaaggg  ggattggaa  gctgagacg  ttggctagg  gagcaggca  gtgggccag  300
aagcaaagg  catagagcc  acgaaaggc  ggggcagcc  ggccgcctg  aaggatgcc  360
atagctgct  tcgctgcag  cactgctct  taggctgta  tggtcatcg  catcactgc  420
gctgccaac  ctgtccagc  ccccagggc  aaactccat  ccctctata  ccacctctt  480
ctctgaatc  tctgtggac  cagcagaac  agtgctgtc  gtgcgcact  gctctacac  540
ctgcaccga  agctgctcc  aacgtctct  taggaagcg  tgctcccgc  gaa  593



<210> 5959
<211> 1508
<212> DNA
<213> Homo sapiens
<308> BC002713
<400> 5959

ggcacgagg  gcggagtct  gaagtgcgg  ggccgggcg  gcggggtgg  cggcgagcg  60
agccggccg  agcgggccg  gcagcggcc  ccgccgtcc  ggggcggac  ggcgcgggc  120
ggaggatgg  gctgaactc  ctgctgatc  tgctggagg  ggccgagta  ctggagcgc  180
gggatcgag  ggccgagca  ggctacgcc  cggtgctgc  cttcgacgg  gacttcgcc  240
gggagaaaa  aaaggcggc  ggcctggtg  gcaaggccc  gaacaacag  cctcctcag  300
gagcaagcc  ggcccccgc  gccgcttct  tccaaacca  gtccctgac  cgtggagaa  360
tctggggcg  gagctgggg  tcccccagc  tggagaatc  aaagctgac  accagcgtc  420
tggccaagg  tgcccgaac  ctgcctcta  gctgagcgt  tcacacatg  agccagttc  480
tcttcaccc  aggctcaga  aggtcttca  acaacgagc  attctggaa  ctccagctg  540
tgctgggct  cctggcact  cccgcttgc  ggtcagggc  tgccgagct  cctgcccct  600
ccagctggg  agagtcccc  gcaaggagg  agggcccag  ttccacatc  ggagccctg  660
tcagcatag  tgcccacgg  ctgttctca  attcctaat  attccagaa  tattaaacg  720
cattgctgc  aacctcggc  ggtgccgtg  gaggggctt  atgaccacc  cagggagct  780
agaccccaa  cctggatcc  aggagaaag  agtggaccg  ggaaggaag  aaggcaagg  840
tgtctgtcc  tccgtccgt  tgtccacct  cctgtcagt  cacataggc  cctggcgtg  900
acaaggggt  tgtgaaggg  gggaactgg  tgagcacct  gggcaggtg  gtggttaag  960
tccttccca  ttcgcaggt  tcagaacct  gggctgggc  ctcggggcc  ggcaggcca  1020
cccagccca  gccgagctg  gcagcgtct  ctctggtag  actgtcaga  gcacacgcg  1080
acgcaccta  acacaccca  tcatgtaca  gctcacaca  gcagacaca  ctgggcgtc  1140
cgaggtcac  tgttctggg  atgatggcc  tcaggggtc  tctggcaaa  agcccctgg  1200
ctgtgcctg  atccccctc  agctcctgc  cacccacgc  cacccagta  tcctgcctg  1260
ctgcacagg  gaggggctt  tcttcctgg  tggggctgg  gtgaactgg  ggctggtta  1320
gttgcagcc  ctgggtcct  gggggctta  tcatctccc  tttttaaac  aaaagcaaa  1380
aagtaaaat  ctgcactgc  cagcagccc  gttagggct  ctggagcca  cttaggaaa  1440
ggcttctca  gagctctgc  gcggcagct  cagctggca  agaggcttt  ccagaaaaa  1500
aaaaaaaa  1508



<210> 5960
<211> 209
<212> PRT
<213> Homo sapiens
<308> Q14582
<400> 5960

Met Glu Leu Asn Ser Leu Leu Ile Leu Leu Glu Ala Ala Glu Tyr Leu 
  1               5                  10                  15
Glu Arg Arg Asp Arg Glu Ala Glu His Gly Tyr Ala Ser Val Leu Pro 
             20                  25                  30
Phe Asp Gly Asp Phe Ala Arg Glu Lys Thr Lys Ala Ala Gly Leu Val 
         35                  40                  45
Arg Lys Ala Pro Asn Asn Arg Ser Ser His Asn Glu Leu Glu Lys His 
     50                  55                  60
Arg Arg Ala Lys Leu Arg Leu Tyr Leu Glu Gln Leu Lys Gln Leu Val 
 65                  70                  75                  80
Pro Leu Gly Pro Asp Ser Thr Arg His Thr Thr Leu Ser Leu Leu Lys 
                 85                  90                  95
Arg Ala Lys Val His Ile Lys Lys Leu Glu Glu Gln Asp Arg Arg Ala 
             100                105                110
Leu Ser Ile Lys Glu Gln Leu Gln Gln Glu His Arg Phe Leu Lys Arg 
         115                120                125
Arg Leu Glu Gln Leu Ser Val Gln Ser Val Glu Arg Val Arg Thr Asp 
     130                135                140
Ser Thr Gly Ser Ala Val Ser Thr Asp Asp Ser Glu Gln Glu Val Asp 
 145                150                155                160
Ile Glu Gly Met Glu Phe Gly Pro Gly Glu Leu Asp Ser Val Gly Ser 
                 165                170                175
Ser Ser Asp Ala Asp Asp His Tyr Ser Leu Gln Ser Gly Thr Gly Gly 
             180                185                190
Asp Ser Gly Phe Gly Pro His Cys Arg Arg Leu Gly Arg Pro Ala Leu 
         195                200                205
Ser 
     210



<210> 5961
<211> 644
<212> DNA
<213> Rattus norvegicus
<308> AA892851
<400> 5961

caaagagaa  aattttatt  atataaaat  cacttataa  atgtccaca  aagacatgt  60
atttttcac  gctatataa  tttattggg  atgttattc  catctattg  cacctaaaa  120
atactgtaa  caatgggtt  ttccctaag  caaatgcat  cgtgattct  agcaatcat  180
ggtttgatt  ttagtaggt  acaaggtca  atctctgtg  aatgtcagt  accgctgta  240
tgtgacagg  ttcagcgca  cattgcaca  actgcttca  aacagtccc  accgggtct  300
gacccagga  gcaaagcac  ccctctgct  gaaacggca  ctctggaag  tctgcgtca  360
agctccagg  ctctcgctg  agcactcta  gggcacgtg  gatgacgtg  acacacgca  420
gactaaaaa  tttacctct  gtaaacaag  gcaacatta  cgtcaactc  cctgcatat  480
taagtagta  agtctacgt  tttgtaaac  aacaaaaca  acaaatcta  ttttaaaaa  540
ttccatcag  tcgtaattc  tctgtgatc  aagtgagtc  acactgaat  tctgaaagg  600
gcatgtatt  ccttaggta  taaagctct  caaggggtg  ttca  644



<210> 5962
<211> 186
<212> DNA
<213> Homo sapiens
<308> BE139189
<400> 5962

ttttttaaa  agaaaaatt  ttattgtga  ataaaatgc  cttataaaa  gtccaccag  60
aggcatgta  ttcttcact  ctatataaa  ttactggga  tatgttatt  accatctag  120
tatgatact  ccaactaaa  catactgta  acgatgagt  atactctat  acaaatgca  180
cactga  186



<210> 5963
<211> 350
<212> PRT
<213> Homo sapiens
<308> AAC50062
<400> 5963

Met Ser His Gln Thr Gly Ile Gln Ala Ser Glu Asp Val Lys Glu Ile 
  1               5                  10                  15
Phe Ala Arg Ala Arg Asn Gly Lys Tyr Arg Leu Leu Lys Ile Ser Ile 
             20                  25                  30
Glu Asn Glu Gln Leu Val Ile Gly Ser Tyr Ser Gln Pro Ser Asp Ser 
         35                  40                  45
Trp Asp Lys Asp Tyr Asp Ser Phe Val Leu Pro Leu Leu Glu Asp Lys 
     50                  55                  60
Gln Pro Cys Tyr Ile Leu Phe Arg Leu Asp Ser Gln Asn Ala Gln Gly 
 65                  70                  75                  80
Tyr Glu Trp Ile Phe Ile Ala Trp Ser Pro Asp His Ser His Val Arg 
                 85                  90                  95
Gln Lys Met Leu Tyr Ala Ala Thr Arg Ala Thr Leu Lys Lys Glu Phe 
             100                105                110
Gly Gly Gly His Ile Lys Asp Glu Val Phe Gly Thr Val Lys Glu Asp 
         115                120                125
Val Ser Leu His Gly Tyr Lys Lys Tyr Leu Leu Ser Gln Ser Ser Pro 
     130                135                140
Ala Pro Leu Thr Ala Ala Glu Glu Glu Leu Arg Gln Ile Lys Ile Asn 
 145                150                155                160
Glu Val Gln Thr Asp Val Gly Val Asp Thr Lys His Gln Thr Leu Gln 
                 165                170                175
Gly Val Ala Phe Pro Ile Ser Arg Glu Ala Phe Gln Ala Leu Glu Lys 
             180                185                190
Leu Asn Asn Arg Gln Leu Asn Tyr Val Gln Leu Glu Ile Asp Ile Lys 
         195                200                205
Asn Glu Ile Ile Ile Leu Ala Asn Thr Thr Asn Thr Glu Leu Lys Asp 
     210                215                220
Leu Pro Lys Arg Ile Pro Lys Asp Ser Ala Arg Tyr His Phe Phe Leu 
 225                230                235                240
Tyr Lys His Ser His Glu Gly Asp Tyr Leu Glu Ser Ile Val Phe Ile 
                 245                250                255
Tyr Ser Met Pro Gly Tyr Thr Cys Ser Ile Arg Glu Arg Met Leu Tyr 
             260                265                270
Ser Ser Cys Lys Ser Arg Leu Leu Glu Ile Val Glu Arg Gln Leu Gln 
         275                280                285
Met Asp Val Ile Arg Lys Ile Glu Ile Asp Asn Gly Asp Glu Leu Thr 
     290                295                300
Ala Asp Phe Leu Tyr Glu Glu Val His Pro Lys Gln His Ala His Lys 
 305                310                315                320
Gln Ser Phe Ala Lys Pro Lys Gly Pro Ala Gly Lys Arg Gly Ile Arg 
                 325                330                335
Arg Leu Ile Arg Gly Pro Ala Glu Thr Glu Ala Thr Thr Asp 
             340                345                350



<210> 5964
<211> 644
<212> DNA
<213> Rattus norvegicus
<308> AA892851
<400> 5964

caaagagaa  aattttatt  atataaaat  cacttataa  atgtccaca  aagacatgt  60
atttttcac  gctatataa  tttattggg  atgttattc  catctattg  cacctaaaa  120
atactgtaa  caatgggtt  ttccctaag  caaatgcat  cgtgattct  agcaatcat  180
ggtttgatt  ttagtaggt  acaaggtca  atctctgtg  aatgtcagt  accgctgta  240
tgtgacagg  ttcagcgca  cattgcaca  actgcttca  aacagtccc  accgggtct  300
gacccagga  gcaaagcac  ccctctgct  gaaacggca  ctctggaag  tctgcgtca  360
agctccagg  ctctcgctg  agcactcta  gggcacgtg  gatgacgtg  acacacgca  420
gactaaaaa  tttacctct  gtaaacaag  gcaacatta  cgtcaactc  cctgcatat  480
taagtagta  agtctacgt  tttgtaaac  aacaaaaca  acaaatcta  ttttaaaaa  540
ttccatcag  tcgtaattc  tctgtgatc  aagtgagtc  acactgaat  tctgaaagg  600
gcatgtatt  ccttaggta  taaagctct  caaggggtg  ttca  644



<210> 5965
<211> 186
<212> DNA
<213> Homo sapiens
<308> BE139189
<400> 5965

ttttttaaa  agaaaaatt  ttattgtga  ataaaatgc  cttataaaa  gtccaccag  60
aggcatgta  ttcttcact  ctatataaa  ttactggga  tatgttatt  accatctag  120
tatgatact  ccaactaaa  catactgta  acgatgagt  atactctat  acaaatgca  180
cactga  186



<210> 5966
<211> 350
<212> PRT
<213> Homo sapiens
<308> AAC50062
<400> 5966

Met Ser His Gln Thr Gly Ile Gln Ala Ser Glu Asp Val Lys Glu Ile 
  1               5                  10                  15
Phe Ala Arg Ala Arg Asn Gly Lys Tyr Arg Leu Leu Lys Ile Ser Ile 
             20                  25                  30
Glu Asn Glu Gln Leu Val Ile Gly Ser Tyr Ser Gln Pro Ser Asp Ser 
         35                  40                  45
Trp Asp Lys Asp Tyr Asp Ser Phe Val Leu Pro Leu Leu Glu Asp Lys 
     50                  55                  60
Gln Pro Cys Tyr Ile Leu Phe Arg Leu Asp Ser Gln Asn Ala Gln Gly 
 65                  70                  75                  80
Tyr Glu Trp Ile Phe Ile Ala Trp Ser Pro Asp His Ser His Val Arg 
                 85                  90                  95
Gln Lys Met Leu Tyr Ala Ala Thr Arg Ala Thr Leu Lys Lys Glu Phe 
             100                105                110
Gly Gly Gly His Ile Lys Asp Glu Val Phe Gly Thr Val Lys Glu Asp 
         115                120                125
Val Ser Leu His Gly Tyr Lys Lys Tyr Leu Leu Ser Gln Ser Ser Pro 
     130                135                140
Ala Pro Leu Thr Ala Ala Glu Glu Glu Leu Arg Gln Ile Lys Ile Asn 
 145                150                155                160
Glu Val Gln Thr Asp Val Gly Val Asp Thr Lys His Gln Thr Leu Gln 
                 165                170                175
Gly Val Ala Phe Pro Ile Ser Arg Glu Ala Phe Gln Ala Leu Glu Lys 
             180                185                190
Leu Asn Asn Arg Gln Leu Asn Tyr Val Gln Leu Glu Ile Asp Ile Lys 
         195                200                205
Asn Glu Ile Ile Ile Leu Ala Asn Thr Thr Asn Thr Glu Leu Lys Asp 
     210                215                220
Leu Pro Lys Arg Ile Pro Lys Asp Ser Ala Arg Tyr His Phe Phe Leu 
 225                230                235                240
Tyr Lys His Ser His Glu Gly Asp Tyr Leu Glu Ser Ile Val Phe Ile 
                 245                250                255
Tyr Ser Met Pro Gly Tyr Thr Cys Ser Ile Arg Glu Arg Met Leu Tyr 
             260                265                270
Ser Ser Cys Lys Ser Arg Leu Leu Glu Ile Val Glu Arg Gln Leu Gln 
         275                280                285
Met Asp Val Ile Arg Lys Ile Glu Ile Asp Asn Gly Asp Glu Leu Thr 
     290                295                300
Ala Asp Phe Leu Tyr Glu Glu Val His Pro Lys Gln His Ala His Lys 
 305                310                315                320
Gln Ser Phe Ala Lys Pro Lys Gly Pro Ala Gly Lys Arg Gly Ile Arg 
                 325                330                335
Arg Leu Ile Arg Gly Pro Ala Glu Thr Glu Ala Thr Thr Asp 
             340                345                350



<210> 5967
<211> 644
<212> DNA
<213> Rattus norvegicus
<308> AA892851
<400> 5967

caaagagaa  aattttatt  atataaaat  cacttataa  atgtccaca  aagacatgt  60
atttttcac  gctatataa  tttattggg  atgttattc  catctattg  cacctaaaa  120
atactgtaa  caatgggtt  ttccctaag  caaatgcat  cgtgattct  agcaatcat  180
ggtttgatt  ttagtaggt  acaaggtca  atctctgtg  aatgtcagt  accgctgta  240
tgtgacagg  ttcagcgca  cattgcaca  actgcttca  aacagtccc  accgggtct  300
gacccagga  gcaaagcac  ccctctgct  gaaacggca  ctctggaag  tctgcgtca  360
agctccagg  ctctcgctg  agcactcta  gggcacgtg  gatgacgtg  acacacgca  420
gactaaaaa  tttacctct  gtaaacaag  gcaacatta  cgtcaactc  cctgcatat  480
taagtagta  agtctacgt  tttgtaaac  aacaaaaca  acaaatcta  ttttaaaaa  540
ttccatcag  tcgtaattc  tctgtgatc  aagtgagtc  acactgaat  tctgaaagg  600
gcatgtatt  ccttaggta  taaagctct  caaggggtg  ttca  644



<210> 5968
<211> 186
<212> DNA
<213> Homo sapiens
<308> BE139189
<400> 5968

ttttttaaa  agaaaaatt  ttattgtga  ataaaatgc  cttataaaa  gtccaccag  60
aggcatgta  ttcttcact  ctatataaa  ttactggga  tatgttatt  accatctag  120
tatgatact  ccaactaaa  catactgta  acgatgagt  atactctat  acaaatgca  180
cactga  186



<210> 5969
<211> 350
<212> PRT
<213> Homo sapiens
<308> AAC50062
<400> 5969

Met Ser His Gln Thr Gly Ile Gln Ala Ser Glu Asp Val Lys Glu Ile 
  1               5                  10                  15
Phe Ala Arg Ala Arg Asn Gly Lys Tyr Arg Leu Leu Lys Ile Ser Ile 
             20                  25                  30
Glu Asn Glu Gln Leu Val Ile Gly Ser Tyr Ser Gln Pro Ser Asp Ser 
         35                  40                  45
Trp Asp Lys Asp Tyr Asp Ser Phe Val Leu Pro Leu Leu Glu Asp Lys 
     50                  55                  60
Gln Pro Cys Tyr Ile Leu Phe Arg Leu Asp Ser Gln Asn Ala Gln Gly 
 65                  70                  75                  80
Tyr Glu Trp Ile Phe Ile Ala Trp Ser Pro Asp His Ser His Val Arg 
                 85                  90                  95
Gln Lys Met Leu Tyr Ala Ala Thr Arg Ala Thr Leu Lys Lys Glu Phe 
             100                105                110
Gly Gly Gly His Ile Lys Asp Glu Val Phe Gly Thr Val Lys Glu Asp 
         115                120                125
Val Ser Leu His Gly Tyr Lys Lys Tyr Leu Leu Ser Gln Ser Ser Pro 
     130                135                140
Ala Pro Leu Thr Ala Ala Glu Glu Glu Leu Arg Gln Ile Lys Ile Asn 
 145                150                155                160
Glu Val Gln Thr Asp Val Gly Val Asp Thr Lys His Gln Thr Leu Gln 
                 165                170                175
Gly Val Ala Phe Pro Ile Ser Arg Glu Ala Phe Gln Ala Leu Glu Lys 
             180                185                190
Leu Asn Asn Arg Gln Leu Asn Tyr Val Gln Leu Glu Ile Asp Ile Lys 
         195                200                205
Asn Glu Ile Ile Ile Leu Ala Asn Thr Thr Asn Thr Glu Leu Lys Asp 
     210                215                220
Leu Pro Lys Arg Ile Pro Lys Asp Ser Ala Arg Tyr His Phe Phe Leu 
 225                230                235                240
Tyr Lys His Ser His Glu Gly Asp Tyr Leu Glu Ser Ile Val Phe Ile 
                 245                250                255
Tyr Ser Met Pro Gly Tyr Thr Cys Ser Ile Arg Glu Arg Met Leu Tyr 
             260                265                270
Ser Ser Cys Lys Ser Arg Leu Leu Glu Ile Val Glu Arg Gln Leu Gln 
         275                280                285
Met Asp Val Ile Arg Lys Ile Glu Ile Asp Asn Gly Asp Glu Leu Thr 
     290                295                300
Ala Asp Phe Leu Tyr Glu Glu Val His Pro Lys Gln His Ala His Lys 
 305                310                315                320
Gln Ser Phe Ala Lys Pro Lys Gly Pro Ala Gly Lys Arg Gly Ile Arg 
                 325                330                335
Arg Leu Ile Arg Gly Pro Ala Glu Thr Glu Ala Thr Thr Asp 
             340                345                350



<210> 5970
<211> 644
<212> DNA
<213> Rattus norvegicus
<308> AA892851
<400> 5970

caaagagaa  aattttatt  atataaaat  cacttataa  atgtccaca  aagacatgt  60
atttttcac  gctatataa  tttattggg  atgttattc  catctattg  cacctaaaa  120
atactgtaa  caatgggtt  ttccctaag  caaatgcat  cgtgattct  agcaatcat  180
ggtttgatt  ttagtaggt  acaaggtca  atctctgtg  aatgtcagt  accgctgta  240
tgtgacagg  ttcagcgca  cattgcaca  actgcttca  aacagtccc  accgggtct  300
gacccagga  gcaaagcac  ccctctgct  gaaacggca  ctctggaag  tctgcgtca  360
agctccagg  ctctcgctg  agcactcta  gggcacgtg  gatgacgtg  acacacgca  420
gactaaaaa  tttacctct  gtaaacaag  gcaacatta  cgtcaactc  cctgcatat  480
taagtagta  agtctacgt  tttgtaaac  aacaaaaca  acaaatcta  ttttaaaaa  540
ttccatcag  tcgtaattc  tctgtgatc  aagtgagtc  acactgaat  tctgaaagg  600
gcatgtatt  ccttaggta  taaagctct  caaggggtg  ttca  644



<210> 5971
<211> 186
<212> DNA
<213> Homo sapiens
<308> BE139189
<400> 5971

ttttttaaa  agaaaaatt  ttattgtga  ataaaatgc  cttataaaa  gtccaccag  60
aggcatgta  ttcttcact  ctatataaa  ttactggga  tatgttatt  accatctag  120
tatgatact  ccaactaaa  catactgta  acgatgagt  atactctat  acaaatgca  180
cactga  186



<210> 5972
<211> 350
<212> PRT
<213> Homo sapiens
<308> AAC50062
<400> 5972

Met Ser His Gln Thr Gly Ile Gln Ala Ser Glu Asp Val Lys Glu Ile 
  1               5                  10                  15
Phe Ala Arg Ala Arg Asn Gly Lys Tyr Arg Leu Leu Lys Ile Ser Ile 
             20                  25                  30
Glu Asn Glu Gln Leu Val Ile Gly Ser Tyr Ser Gln Pro Ser Asp Ser 
         35                  40                  45
Trp Asp Lys Asp Tyr Asp Ser Phe Val Leu Pro Leu Leu Glu Asp Lys 
     50                  55                  60
Gln Pro Cys Tyr Ile Leu Phe Arg Leu Asp Ser Gln Asn Ala Gln Gly 
 65                  70                  75                  80
Tyr Glu Trp Ile Phe Ile Ala Trp Ser Pro Asp His Ser His Val Arg 
                 85                  90                  95
Gln Lys Met Leu Tyr Ala Ala Thr Arg Ala Thr Leu Lys Lys Glu Phe 
             100                105                110
Gly Gly Gly His Ile Lys Asp Glu Val Phe Gly Thr Val Lys Glu Asp 
         115                120                125
Val Ser Leu His Gly Tyr Lys Lys Tyr Leu Leu Ser Gln Ser Ser Pro 
     130                135                140
Ala Pro Leu Thr Ala Ala Glu Glu Glu Leu Arg Gln Ile Lys Ile Asn 
 145                150                155                160
Glu Val Gln Thr Asp Val Gly Val Asp Thr Lys His Gln Thr Leu Gln 
                 165                170                175
Gly Val Ala Phe Pro Ile Ser Arg Glu Ala Phe Gln Ala Leu Glu Lys 
             180                185                190
Leu Asn Asn Arg Gln Leu Asn Tyr Val Gln Leu Glu Ile Asp Ile Lys 
         195                200                205
Asn Glu Ile Ile Ile Leu Ala Asn Thr Thr Asn Thr Glu Leu Lys Asp 
     210                215                220
Leu Pro Lys Arg Ile Pro Lys Asp Ser Ala Arg Tyr His Phe Phe Leu 
 225                230                235                240
Tyr Lys His Ser His Glu Gly Asp Tyr Leu Glu Ser Ile Val Phe Ile 
                 245                250                255
Tyr Ser Met Pro Gly Tyr Thr Cys Ser Ile Arg Glu Arg Met Leu Tyr 
             260                265                270
Ser Ser Cys Lys Ser Arg Leu Leu Glu Ile Val Glu Arg Gln Leu Gln 
         275                280                285
Met Asp Val Ile Arg Lys Ile Glu Ile Asp Asn Gly Asp Glu Leu Thr 
     290                295                300
Ala Asp Phe Leu Tyr Glu Glu Val His Pro Lys Gln His Ala His Lys 
 305                310                315                320
Gln Ser Phe Ala Lys Pro Lys Gly Pro Ala Gly Lys Arg Gly Ile Arg 
                 325                330                335
Arg Leu Ile Arg Gly Pro Ala Glu Thr Glu Ala Thr Thr Asp 
             340                345                350



<210> 5973
<211> 591
<212> DNA
<213> Rattus norvegicus
<308> AA892854
<400> 5973

gaatgacac  ggatgaata  gaaacgtta  agaatttga  acaagagac  ggtattttg  60
ctgtgtgaa  gatgtgaat  ataaaaata  attagcagg  tcacagtgc  aaggaatat  120
tttatatac  gttaaggag  ctggaactt  aagctgagg  tctttcagt  ttactggtt  180
taatccaag  caataaatt  tgtacaagc  acctttcaa  gtcgaagca  tatttccct  240
atgaagatt  tctctaaag  agacctgct  tgcatcacc  taggctggt  atgcgtctg  300
ttcttaggg  ccttctgga  actattctg  aagcctgat  tttgcaagg  tgcaaacta  360
ctgaagtcc  tctcataaa  ctcttgtta  taggagcta  gggttcaga  tcgacatgt  420
tgcttttat  cctctaggg  ctaggatag  ttaacacta  acaacaggt  tattaccaa  480
gtggcttgt  actaaatgc  tgctcgaaa  tatcctccc  taaggaaca  gaatatggg  540
tgagtatgg  aaggagctc  agtatctcc  ctcagctac  gcaggattt  t  591



<210> 5974
<211> 109
<212> PRT
<213> Rattus norvegicus
<308> NP_061354
<400> 5974

Met Arg Leu Ser Thr Ala Thr Leu Leu Leu Leu Leu Ala Ser Cys Leu 
  1               5                  10                  15
Ser Pro Gly His Gly Ile Leu Glu Ala His Tyr Thr Asn Leu Lys Cys 
             20                  25                  30
Arg Cys Ser Gly Val Ile Ser Thr Val Val Gly Leu Asn Ile Ile Asp 
         35                  40                  45
Arg Ile Gln Val Thr Pro Pro Gly Asn Gly Cys Pro Lys Thr Glu Val 
     50                  55                  60
Val Ile Trp Thr Lys Met Lys Lys Val Ile Cys Val Asn Pro Arg Ala 
 65                  70                  75                  80
Lys Trp Leu Gln Arg Leu Leu Arg His Val Gln Ser Lys Ser Leu Ser 
                 85                  90                  95
Ser Thr Pro Gln Ala Pro Val Ser Lys Arg Arg Ala Ala 
             100                105



<210> 5975
<211> 1216
<212> DNA
<213> Homo sapiens
<308> NM_006419
<400> 5975

ttcggcact  gggagaaga  gtttgaaaa  actgactct  ctaatgagc  tggactcag  60
gctcaagtc  gaactctac  tccagacag  atgaagttc  tctcgacat  tctgcttct  120
atgctgctg  tcagcagcc  ctctccagt  caaggtgtt  tggaggtct  ttacacaag  180
ttgaggtgt  gatgtgtcc  agagagctc  gtctttatc  ctagacgct  cattgatcg  240
attcaaatc  tgccccgtg  gaatggttg  ccaagaaaa  aaatcatag  ctggaagaa  300
aacaagtca  ttgtgtgtg  ggaccctca  gctgaatgg  tacaaagaa  gatggaagt  360
ttgagaaaa  gaagttctt  aactctacc  gttccagtg  ttaagagaa  gattccctg  420
tgctgatat  tccactaag  acacctgca  tcttccctt  tccctgctc  ggattttag  480
tttgtgctt  gttaaatct  ttccaggga  aaagaactt  cccatacaa  taaggcatg  540
ggactatgt  aaaaataac  ttgcaggag  tgatggggc  aactcaagc  tcttcactc  600
cagcaccct  tatacactt  gagtttgca  tcttattca  cagggagga  agtttcttt  660
aaaatagtt  ttcagttat  agtaataca  gattatttt  attatatac  tgttgttta  720
tgtttaaaa  ttcttagaa  acaatggaa  gagaattta  gcctcaaat  tgaacatgt  780
gcttgaatt  agaagaaaa  tatggcata  attaaaagc  ggcttctat  aaagactca  840
aaagctgcc  gggaggcag  tggaacttg  gcctgtcaa  aggcaaagg  atccatgta  900
tagatatcc  ctgcttaaa  actcactac  gaggagaat  aagtcctac  tttaaagaa  960
ttctttata  aatttactg  ctaagatta  tagcattcg  agatcccca  acttcatag  1020
atactcagg  aaagcattt  aagggtgat  tacacatgt  tcctttcac  catttgcct  1080
gacaaactt  tttcactca  atctttttc  ctgactttt  ttgtggggg  ggggccggg  1140
ggactctgg  atctaattc  ttaatgatt  ctataaatc  aatgacatt  aataaagtt  1200
agcaaacat  ttactt  1216



<210> 5976
<211> 109
<212> PRT
<213> Homo sapiens
<308> O43927
<400> 5976

Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser 
  1               5                  10                  15
Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg 
             20                  25                  30
Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 
         35                  40                  45
Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 
     50                  55                  60
Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 
 65                  70                  75                  80
Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 
                 85                  90                  95
Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
             100                105



<210> 5977
<211> 436
<212> DNA
<213> Rattus norvegicus
<308> AA892860
<400> 5977

ccatataat  atttaatat  tgccagcca  acaaagtag  ttatcttta  tcaattaaa  60
aaaaacaga  ctgtcaggt  tattatata  cattcacta  atacacatg  tttaggcga  120
gcaaggtaa  tctaggtat  ctaactgtt  aactattag  gaaacacag  aggtgtcag  180
agcccagcg  gttcctgct  acattgggt  cctgcgttt  tgtggacag  tagagggac  240
gccacaagc  aggacagat  ttaccagta  acgtctgag  gacagaggg  ctggggatg  300
gtctagcag  gattaacag  ctcctaagt  tggatagca  acttgacag  tacgcttta  360
caagttcct  ttcgatcat  ttcatgacg  caaagtttt  gtttgaagg  aacaccacc  420
cattttacc  cgtgcc  436



<210> 5978
<211> 293
<212> DNA
<213> Homo sapiens
<308> AA032215
<400> 5978

ttttttttt  ttcttcata  aataattta  tatatgcca  ccaaacaaa  tatttgtat  60
tttattcaa  taaattaaa  cagacctgc  aggtatatt  tataacatt  actatatac  120
tatgattta  gcaatgcaa  ataattcta  atatgctga  tactcaact  tgtgtaaaa  180
atgagcggt  tcagtgatg  ccagcaagt  ctccttttc  cattgggtg  ctgcatttc  240
atggtatgg  tagagggat  gctacgagc  atgacttgg  ctaccagta  act  293



<210> 5979
<211> 1333
<212> PRT
<213> Homo sapiens
<308> Q07889
<400> 5979

Met Gln Ala Gln Gln Leu Pro Tyr Glu Phe Phe Ser Glu Glu Asn Ala 
  1               5                  10                  15
Pro Lys Trp Arg Gly Leu Leu Val Pro Ala Leu Lys Lys Val Gln Gly 
             20                  25                  30
Gln Val His Pro Thr Leu Glu Ser Asn Asp Asp Ala Leu Gln Tyr Val 
         35                  40                  45
Glu Glu Leu Ile Leu Gln Leu Leu Asn Met Leu Cys Gln Ala Gln Pro 
     50                  55                  60
Arg Ser Ala Ser Asp Val Glu Glu Arg Val Gln Lys Ser Phe Pro His 
 65                  70                  75                  80
Pro Ile Asp Lys Trp Ala Ile Ala Asp Ala Gln Ser Ala Ile Glu Lys 
                 85                  90                  95
Arg Lys Arg Arg Asn Pro Leu Ser Leu Pro Val Glu Lys Ile His Pro 
             100                105                110
Leu Leu Lys Glu Val Leu Gly Tyr Lys Ile Asp His Gln Val Ser Val 
         115                120                125
Tyr Ile Val Ala Val Leu Glu Tyr Ile Ser Ala Asp Ile Leu Lys Leu 
     130                135                140
Val Gly Asn Tyr Val Arg Asn Ile Arg His Tyr Glu Ile Thr Lys Gln 
 145                150                155                160
Asp Ile Lys Val Ala Met Cys Ala Asp Lys Val Leu Met Asp Met Phe 
                 165                170                175
His Gln Asp Val Glu Asp Ile Asn Ile Leu Ser Leu Thr Asp Glu Glu 
             180                185                190
Pro Ser Thr Ser Gly Glu Gln Thr Tyr Tyr Asp Leu Val Lys Ala Phe 
         195                200                205
Met Ala Glu Ile Arg Gln Tyr Ile Arg Glu Leu Asn Leu Ile Ile Lys 
     210                215                220
Val Phe Arg Glu Pro Phe Val Ser Asn Ser Lys Leu Phe Ser Ala Asn 
 225                230                235                240
Asp Val Glu Asn Ile Phe Ser Arg Ile Val Asp Ile His Glu Leu Ser 
                 245                250                255
Val Lys Leu Leu Gly His Ile Glu Asp Thr Val Glu Met Thr Asp Glu 
             260                265                270
Gly Ser Pro His Pro Leu Val Gly Ser Cys Phe Glu Asp Leu Ala Glu 
         275                280                285
Glu Leu Ala Phe Asp Pro Tyr Glu Ser Tyr Ala Arg Asp Ile Leu Arg 
     290                295                300
Pro Gly Phe His Asp Arg Phe Leu Ser Gln Leu Ser Lys Pro Gly Ala 
 305                310                315                320
Ala Leu Tyr Leu Gln Ser Ile Gly Glu Gly Phe Lys Glu Ala Val Gln 
                 325                330                335
Tyr Val Leu Pro Arg Leu Leu Leu Ala Pro Val Tyr His Cys Leu His 
             340                345                350
Tyr Phe Glu Leu Leu Lys Gln Leu Glu Glu Lys Ser Glu Asp Gln Glu 
         355                360                365
Asp Lys Glu Cys Leu Lys Gln Ala Ile Thr Ala Leu Leu Asn Val Gln 
     370                375                380
Ser Gly Met Glu Lys Ile Cys Ser Lys Ser Leu Ala Lys Arg Arg Leu 
 385                390                395                400
Ser Glu Ser Ala Cys Arg Phe Tyr Ser Gln Gln Met Lys Gly Lys Gln 
                 405                410                415
Leu Ala Ile Lys Lys Met Asn Glu Ile Gln Lys Asn Ile Asp Gly Trp 
             420                425                430
Glu Gly Lys Asp Ile Gly Gln Cys Cys Asn Glu Phe Ile Met Glu Gly 
         435                440                445
Thr Leu Thr Arg Val Gly Ala Lys His Glu Arg His Ile Phe Leu Phe 
     450                455                460
Asp Gly Leu Met Ile Cys Cys Lys Ser Asn His Gly Gln Pro Arg Leu 
 465                470                475                480
Pro Gly Ala Ser Asn Ala Glu Tyr Arg Leu Lys Glu Lys Phe Phe Met 
                 485                490                495
Arg Lys Val Gln Ile Asn Asp Lys Asp Asp Thr Asn Glu Tyr Lys His 
             500                505                510
Ala Phe Glu Ile Ile Leu Lys Asp Glu Asn Ser Val Ile Phe Ser Ala 
         515                520                525
Lys Ser Ala Glu Glu Lys Asn Asn Trp Met Ala Ala Leu Ile Ser Leu 
     530                535                540
Gln Tyr Arg Ser Thr Leu Glu Arg Met Leu Asp Val Thr Met Leu Gln 
 545                550                555                560
Glu Glu Lys Glu Glu Gln Met Arg Leu Pro Ser Ala Asp Val Tyr Arg 
                 565                570                575
Phe Ala Glu Pro Asp Ser Glu Glu Asn Ile Ile Phe Glu Glu Asn Met 
             580                585                590
Gln Pro Lys Ala Gly Ile Pro Ile Ile Lys Ala Gly Thr Val Ile Lys 
         595                600                605
Leu Ile Glu Arg Leu Thr Tyr His Met Tyr Ala Asp Pro Asn Phe Val 
     610                615                620
Arg Thr Phe Leu Thr Thr Tyr Arg Ser Phe Cys Lys Pro Gln Glu Leu 
 625                630                635                640
Leu Ser Leu Ile Ile Glu Arg Phe Glu Ile Pro Glu Pro Glu Pro Thr 
                 645                650                655
Glu Ala Asp Arg Ile Ala Ile Glu Asn Gly Asp Gln Pro Leu Ser Ala 
             660                665                670
Glu Leu Lys Arg Phe Arg Lys Glu Tyr Ile Gln Pro Val Gln Leu Arg 
         675                680                685
Val Leu Asn Val Cys Arg His Trp Val Glu His His Phe Tyr Asp Phe 
     690                695                700
Glu Arg Asp Ala Tyr Leu Leu Gln Arg Met Glu Glu Phe Ile Gly Thr 
 705                710                715                720
Val Arg Gly Lys Ala Met Lys Lys Trp Val Glu Ser Ile Thr Lys Ile 
                 725                730                735
Ile Gln Arg Lys Lys Ile Ala Arg Asp Asn Gly Pro Gly His Asn Ile 
             740                745                750
Thr Phe Gln Ser Ser Pro Pro Thr Val Glu Trp His Ile Ser Arg Pro 
         755                760                765
Gly His Ile Glu Thr Phe Asp Leu Leu Thr Leu His Pro Ile Glu Ile 
     770                775                780
Ala Arg Gln Leu Thr Leu Leu Glu Ser Asp Leu Tyr Arg Ala Val Gln 
 785                790                795                800
Pro Ser Glu Leu Val Gly Ser Val Trp Thr Lys Glu Asp Lys Glu Ile 
                 805                810                815
Asn Ser Pro Asn Leu Leu Lys Met Ile Arg His Thr Thr Asn Leu Thr 
             820                825                830
Leu Trp Phe Glu Lys Cys Ile Val Glu Thr Glu Asn Leu Glu Glu Arg 
         835                840                845
Val Ala Val Val Ser Arg Ile Ile Glu Ile Leu Gln Val Phe Gln Glu 
     850                855                860
Leu Asn Asn Phe Asn Gly Val Leu Glu Val Val Ser Ala Met Asn Ser 
 865                870                875                880
Ser Pro Val Tyr Arg Leu Asp His Thr Phe Glu Gln Ile Pro Ser Arg 
                 885                890                895
Gln Lys Lys Ile Leu Glu Glu Ala His Glu Leu Ser Glu Asp His Tyr 
             900                905                910
Lys Lys Tyr Leu Ala Lys Leu Arg Ser Ile Asn Pro Pro Cys Val Pro 
         915                920                925
Phe Phe Gly Ile Tyr Leu Thr Asn Ile Leu Lys Thr Glu Glu Gly Asn 
     930                935                940
Pro Glu Val Leu Lys Arg His Gly Lys Glu Leu Ile Asn Phe Ser Lys 
 945                950                955                960
Arg Arg Lys Val Ala Glu Ile Thr Gly Glu Ile Gln Gln Tyr Gln Asn 
                 965                970                975
Gln Pro Tyr Cys Leu Arg Val Glu Ser Asp Ile Lys Arg Phe Phe Glu 
             980                985                990
Asn Leu Asn Pro Met Gly Asn Ser Met Glu Lys Glu Phe Thr Asp Tyr 
         995                1000                1005
Leu Phe Asn Lys Ser Leu Glu Ile Glu Pro Arg Asn Pro Lys Pro Leu 
     1010                1015                1020
Pro Arg Phe Pro Lys Lys Tyr Ser Tyr Pro Leu Lys Ser Pro Gly Val 
 1025                1030                1035                1040
Arg Pro Ser Asn Pro Arg Pro Gly Thr Met Arg His Pro Thr Pro Leu 
                 1045                1050                1055
Gln Gln Glu Pro Arg Lys Ile Ser Tyr Ser Arg Ile Pro Glu Ser Glu 
             1060                1065                1070
Thr Glu Ser Thr Ala Ser Ala Pro Asn Ser Pro Arg Thr Pro Leu Thr 
         1075                1080                1085
Pro Pro Pro Ala Ser Gly Ala Ser Ser Thr Thr Asp Val Cys Ser Val 
     1090                1095                1100
Phe Asp Ser Asp His Ser Ser Pro Phe His Ser Ser Asn Asp Thr Val 
 1105                1110                1115                1120
Phe Ile Gln Val Thr Leu Pro His Gly Pro Arg Ser Ala Ser Val Ser 
                 1125                1130                1135
Ser Ile Ser Leu Thr Lys Gly Thr Asp Glu Val Pro Val Pro Pro Pro 
             1140                1145                1150
Val Pro Pro Arg Arg Arg Pro Glu Ser Ala Pro Ala Glu Ser Ser Pro 
         1155                1160                1165
Ser Lys Ile Met Ser Lys His Leu Asp Ser Pro Pro Ala Ile Pro Pro 
     1170                1175                1180
Arg Gln Pro Thr Ser Lys Ala Tyr Ser Pro Arg Tyr Ser Ile Ser Asp 
 1185                1190                1195                1200
Arg Thr Ser Ile Ser Asp Pro Pro Glu Ser Pro Pro Leu Leu Pro Pro 
                 1205                1210                1215
Arg Glu Pro Val Arg Thr Pro Asp Val Phe Ser Ser Ser Pro Leu His 
             1220                1225                1230
Leu Gln Pro Pro Pro Leu Gly Lys Lys Ser Asp His Gly Asn Ala Phe 
         1235                1240                1245
Phe Pro Asn Ser Pro Ser Pro Phe Thr Pro Pro Pro Pro Gln Thr Pro 
     1250                1255                1260
Ser Pro His Gly Thr Arg Arg His Leu Pro Ser Pro Pro Leu Thr Gln 
 1265                1270                1275                1280
Glu Val Asp Leu His Ser Ile Ala Gly Pro Pro Val Pro Pro Arg Gln 
                 1285                1290                1295
Ser Thr Ser Gln His Ile Pro Lys Leu Pro Pro Lys Thr Tyr Lys Arg 
             1300                1305                1310
Glu His Thr His Pro Ser Met His Arg Asp Gly Pro Pro Leu Leu Glu 
         1315                1320                1325
Asn Ala His Ser Ser 
     1330



<210> 5980
<211> 436
<212> DNA
<213> Rattus norvegicus
<308> AA892860
<400> 5980

ccatataat  atttaatat  tgccagcca  acaaagtag  ttatcttta  tcaattaaa  60
aaaaacaga  ctgtcaggt  tattatata  cattcacta  atacacatg  tttaggcga  120
gcaaggtaa  tctaggtat  ctaactgtt  aactattag  gaaacacag  aggtgtcag  180
agcccagcg  gttcctgct  acattgggt  cctgcgttt  tgtggacag  tagagggac  240
gccacaagc  aggacagat  ttaccagta  acgtctgag  gacagaggg  ctggggatg  300
gtctagcag  gattaacag  ctcctaagt  tggatagca  acttgacag  tacgcttta  360
caagttcct  ttcgatcat  ttcatgacg  caaagtttt  gtttgaagg  aacaccacc  420
cattttacc  cgtgcc  436



<210> 5981
<211> 293
<212> DNA
<213> Homo sapiens
<308> AA032215
<400> 5981

ttttttttt  ttcttcata  aataattta  tatatgcca  ccaaacaaa  tatttgtat  60
tttattcaa  taaattaaa  cagacctgc  aggtatatt  tataacatt  actatatac  120
tatgattta  gcaatgcaa  ataattcta  atatgctga  tactcaact  tgtgtaaaa  180
atgagcggt  tcagtgatg  ccagcaagt  ctccttttc  cattgggtg  ctgcatttc  240
atggtatgg  tagagggat  gctacgagc  atgacttgg  ctaccagta  act  293



<210> 5982
<211> 1333
<212> PRT
<213> Homo sapiens
<308> Q07889
<400> 5982

Met Gln Ala Gln Gln Leu Pro Tyr Glu Phe Phe Ser Glu Glu Asn Ala 
  1               5                  10                  15
Pro Lys Trp Arg Gly Leu Leu Val Pro Ala Leu Lys Lys Val Gln Gly 
             20                  25                  30
Gln Val His Pro Thr Leu Glu Ser Asn Asp Asp Ala Leu Gln Tyr Val 
         35                  40                  45
Glu Glu Leu Ile Leu Gln Leu Leu Asn Met Leu Cys Gln Ala Gln Pro 
     50                  55                  60
Arg Ser Ala Ser Asp Val Glu Glu Arg Val Gln Lys Ser Phe Pro His 
 65                  70                  75                  80
Pro Ile Asp Lys Trp Ala Ile Ala Asp Ala Gln Ser Ala Ile Glu Lys 
                 85                  90                  95
Arg Lys Arg Arg Asn Pro Leu Ser Leu Pro Val Glu Lys Ile His Pro 
             100                105                110
Leu Leu Lys Glu Val Leu Gly Tyr Lys Ile Asp His Gln Val Ser Val 
         115                120                125
Tyr Ile Val Ala Val Leu Glu Tyr Ile Ser Ala Asp Ile Leu Lys Leu 
     130                135                140
Val Gly Asn Tyr Val Arg Asn Ile Arg His Tyr Glu Ile Thr Lys Gln 
 145                150                155                160
Asp Ile Lys Val Ala Met Cys Ala Asp Lys Val Leu Met Asp Met Phe 
                 165                170                175
His Gln Asp Val Glu Asp Ile Asn Ile Leu Ser Leu Thr Asp Glu Glu 
             180                185                190
Pro Ser Thr Ser Gly Glu Gln Thr Tyr Tyr Asp Leu Val Lys Ala Phe 
         195                200                205
Met Ala Glu Ile Arg Gln Tyr Ile Arg Glu Leu Asn Leu Ile Ile Lys 
     210                215                220
Val Phe Arg Glu Pro Phe Val Ser Asn Ser Lys Leu Phe Ser Ala Asn 
 225                230                235                240
Asp Val Glu Asn Ile Phe Ser Arg Ile Val Asp Ile His Glu Leu Ser 
                 245                250                255
Val Lys Leu Leu Gly His Ile Glu Asp Thr Val Glu Met Thr Asp Glu 
             260                265                270
Gly Ser Pro His Pro Leu Val Gly Ser Cys Phe Glu Asp Leu Ala Glu 
         275                280                285
Glu Leu Ala Phe Asp Pro Tyr Glu Ser Tyr Ala Arg Asp Ile Leu Arg 
     290                295                300
Pro Gly Phe His Asp Arg Phe Leu Ser Gln Leu Ser Lys Pro Gly Ala 
 305                310                315                320
Ala Leu Tyr Leu Gln Ser Ile Gly Glu Gly Phe Lys Glu Ala Val Gln 
                 325                330                335
Tyr Val Leu Pro Arg Leu Leu Leu Ala Pro Val Tyr His Cys Leu His 
             340                345                350
Tyr Phe Glu Leu Leu Lys Gln Leu Glu Glu Lys Ser Glu Asp Gln Glu 
         355                360                365
Asp Lys Glu Cys Leu Lys Gln Ala Ile Thr Ala Leu Leu Asn Val Gln 
     370                375                380
Ser Gly Met Glu Lys Ile Cys Ser Lys Ser Leu Ala Lys Arg Arg Leu 
 385                390                395                400
Ser Glu Ser Ala Cys Arg Phe Tyr Ser Gln Gln Met Lys Gly Lys Gln 
                 405                410                415
Leu Ala Ile Lys Lys Met Asn Glu Ile Gln Lys Asn Ile Asp Gly Trp 
             420                425                430
Glu Gly Lys Asp Ile Gly Gln Cys Cys Asn Glu Phe Ile Met Glu Gly 
         435                440                445
Thr Leu Thr Arg Val Gly Ala Lys His Glu Arg His Ile Phe Leu Phe 
     450                455                460
Asp Gly Leu Met Ile Cys Cys Lys Ser Asn His Gly Gln Pro Arg Leu 
 465                470                475                480
Pro Gly Ala Ser Asn Ala Glu Tyr Arg Leu Lys Glu Lys Phe Phe Met 
                 485                490                495
Arg Lys Val Gln Ile Asn Asp Lys Asp Asp Thr Asn Glu Tyr Lys His 
             500                505                510
Ala Phe Glu Ile Ile Leu Lys Asp Glu Asn Ser Val Ile Phe Ser Ala 
         515                520                525
Lys Ser Ala Glu Glu Lys Asn Asn Trp Met Ala Ala Leu Ile Ser Leu 
     530                535                540
Gln Tyr Arg Ser Thr Leu Glu Arg Met Leu Asp Val Thr Met Leu Gln 
 545                550                555                560
Glu Glu Lys Glu Glu Gln Met Arg Leu Pro Ser Ala Asp Val Tyr Arg 
                 565                570                575
Phe Ala Glu Pro Asp Ser Glu Glu Asn Ile Ile Phe Glu Glu Asn Met 
             580                585                590
Gln Pro Lys Ala Gly Ile Pro Ile Ile Lys Ala Gly Thr Val Ile Lys 
         595                600                605
Leu Ile Glu Arg Leu Thr Tyr His Met Tyr Ala Asp Pro Asn Phe Val 
     610                615                620
Arg Thr Phe Leu Thr Thr Tyr Arg Ser Phe Cys Lys Pro Gln Glu Leu 
 625                630                635                640
Leu Ser Leu Ile Ile Glu Arg Phe Glu Ile Pro Glu Pro Glu Pro Thr 
                 645                650                655
Glu Ala Asp Arg Ile Ala Ile Glu Asn Gly Asp Gln Pro Leu Ser Ala 
             660                665                670
Glu Leu Lys Arg Phe Arg Lys Glu Tyr Ile Gln Pro Val Gln Leu Arg 
         675                680                685
Val Leu Asn Val Cys Arg His Trp Val Glu His His Phe Tyr Asp Phe 
     690                695                700
Glu Arg Asp Ala Tyr Leu Leu Gln Arg Met Glu Glu Phe Ile Gly Thr 
 705                710                715                720
Val Arg Gly Lys Ala Met Lys Lys Trp Val Glu Ser Ile Thr Lys Ile 
                 725                730                735
Ile Gln Arg Lys Lys Ile Ala Arg Asp Asn Gly Pro Gly His Asn Ile 
             740                745                750
Thr Phe Gln Ser Ser Pro Pro Thr Val Glu Trp His Ile Ser Arg Pro 
         755                760                765
Gly His Ile Glu Thr Phe Asp Leu Leu Thr Leu His Pro Ile Glu Ile 
     770                775                780
Ala Arg Gln Leu Thr Leu Leu Glu Ser Asp Leu Tyr Arg Ala Val Gln 
 785                790                795                800
Pro Ser Glu Leu Val Gly Ser Val Trp Thr Lys Glu Asp Lys Glu Ile 
                 805                810                815
Asn Ser Pro Asn Leu Leu Lys Met Ile Arg His Thr Thr Asn Leu Thr 
             820                825                830
Leu Trp Phe Glu Lys Cys Ile Val Glu Thr Glu Asn Leu Glu Glu Arg 
         835                840                845
Val Ala Val Val Ser Arg Ile Ile Glu Ile Leu Gln Val Phe Gln Glu 
     850                855                860
Leu Asn Asn Phe Asn Gly Val Leu Glu Val Val Ser Ala Met Asn Ser 
 865                870                875                880
Ser Pro Val Tyr Arg Leu Asp His Thr Phe Glu Gln Ile Pro Ser Arg 
                 885                890                895
Gln Lys Lys Ile Leu Glu Glu Ala His Glu Leu Ser Glu Asp His Tyr 
             900                905                910
Lys Lys Tyr Leu Ala Lys Leu Arg Ser Ile Asn Pro Pro Cys Val Pro 
         915                920                925
Phe Phe Gly Ile Tyr Leu Thr Asn Ile Leu Lys Thr Glu Glu Gly Asn 
     930                935                940
Pro Glu Val Leu Lys Arg His Gly Lys Glu Leu Ile Asn Phe Ser Lys 
 945                950                955                960
Arg Arg Lys Val Ala Glu Ile Thr Gly Glu Ile Gln Gln Tyr Gln Asn 
                 965                970                975
Gln Pro Tyr Cys Leu Arg Val Glu Ser Asp Ile Lys Arg Phe Phe Glu 
             980                985                990
Asn Leu Asn Pro Met Gly Asn Ser Met Glu Lys Glu Phe Thr Asp Tyr 
         995                1000                1005
Leu Phe Asn Lys Ser Leu Glu Ile Glu Pro Arg Asn Pro Lys Pro Leu 
     1010                1015                1020
Pro Arg Phe Pro Lys Lys Tyr Ser Tyr Pro Leu Lys Ser Pro Gly Val 
 1025                1030                1035                1040
Arg Pro Ser Asn Pro Arg Pro Gly Thr Met Arg His Pro Thr Pro Leu 
                 1045                1050                1055
Gln Gln Glu Pro Arg Lys Ile Ser Tyr Ser Arg Ile Pro Glu Ser Glu 
             1060                1065                1070
Thr Glu Ser Thr Ala Ser Ala Pro Asn Ser Pro Arg Thr Pro Leu Thr 
         1075                1080                1085
Pro Pro Pro Ala Ser Gly Ala Ser Ser Thr Thr Asp Val Cys Ser Val 
     1090                1095                1100
Phe Asp Ser Asp His Ser Ser Pro Phe His Ser Ser Asn Asp Thr Val 
 1105                1110                1115                1120
Phe Ile Gln Val Thr Leu Pro His Gly Pro Arg Ser Ala Ser Val Ser 
                 1125                1130                1135
Ser Ile Ser Leu Thr Lys Gly Thr Asp Glu Val Pro Val Pro Pro Pro 
             1140                1145                1150
Val Pro Pro Arg Arg Arg Pro Glu Ser Ala Pro Ala Glu Ser Ser Pro 
         1155                1160                1165
Ser Lys Ile Met Ser Lys His Leu Asp Ser Pro Pro Ala Ile Pro Pro 
     1170                1175                1180
Arg Gln Pro Thr Ser Lys Ala Tyr Ser Pro Arg Tyr Ser Ile Ser Asp 
 1185                1190                1195                1200
Arg Thr Ser Ile Ser Asp Pro Pro Glu Ser Pro Pro Leu Leu Pro Pro 
                 1205                1210                1215
Arg Glu Pro Val Arg Thr Pro Asp Val Phe Ser Ser Ser Pro Leu His 
             1220                1225                1230
Leu Gln Pro Pro Pro Leu Gly Lys Lys Ser Asp His Gly Asn Ala Phe 
         1235                1240                1245
Phe Pro Asn Ser Pro Ser Pro Phe Thr Pro Pro Pro Pro Gln Thr Pro 
     1250                1255                1260
Ser Pro His Gly Thr Arg Arg His Leu Pro Ser Pro Pro Leu Thr Gln 
 1265                1270                1275                1280
Glu Val Asp Leu His Ser Ile Ala Gly Pro Pro Val Pro Pro Arg Gln 
                 1285                1290                1295
Ser Thr Ser Gln His Ile Pro Lys Leu Pro Pro Lys Thr Tyr Lys Arg 
             1300                1305                1310
Glu His Thr His Pro Ser Met His Arg Asp Gly Pro Pro Leu Leu Glu 
         1315                1320                1325
Asn Ala His Ser Ser 
     1330



<210> 5983
<211> 593
<212> DNA
<213> Rattus norvegicus
<308> AA892863
<400> 5983

gcattttcc  agatcattt  tacttgacc  tttttttgg  acaaaagag  aggtaatgc  60
aaacatgtt  tatattaaa  cagatgcag  tagtattga  tagaatata  aatttacat  120
acttttgag  caaagtact  ttgacatca  agacatttc  aactaagct  cttatgagc  180
tctgggtgc  tccctccct  accctgagc  gaagaccct  ctcgctcac  ctacctaac  240
tcatggcct  tgctgcatt  acagaagtc  aaaagcagc  aagtcagtg  ttactcatt  300
ggcaaagta  cagtgaatt  acttaaaca  ttgacacct  agggctttc  catcttacg  360
gcattttaa  ctgacgtta  aaggcctga  tgaatagaa  ctcaatgcc  gagttgaga  420
ttttcattg  aaagtgaat  ttcctccag  aagtgtttt  aacaagcct  actgagggt  480
tgacatgcg  gctggacaa  atcctagga  cctggtcac  agataagga  gtacagata  540
acttttcaa  ggcatcatc  caaatgaga  caaactact  accttctgc  gta  593



<210> 5984
<211> 570
<212> DNA
<213> Rattus norvegicus
<308> AA892864
<400> 5984

aaacttaat  aagagtagt  ataccccat  cctgtccac  gctgtccag  gttccctga  60
caggaggga  tgctgactg  ctctctttg  acactctgt  tttatttcc  aaacagaag  120
agagctaaa  ggcgctctg  acagctcct  gacccttcc  tccctacat  cagtgcttg  180
gccctgctg  ggggcacag  gaccttatg  cctatagta  gtggccagc  tctgactgc  240
atgcatggt  agggccacc  gagggggca  agggccctc  caagatcta  aataaattc  300
accaactcc  ggatacctg  atcccacct  cctggagcc  cccccccct  ccagcagcc  360
ggcagttct  cttggcagc  gagcccctc  ccagggttc  atgtgcagt  acatgatcc  420
gaggtaaca  caaggccct  tgtaaagat  aaagtgctc  aagggagca  tgagcccca  480
ttattgctg  cgctaagtg  ggcctggcg  aagcctttg  gcgggcacc  gagaggaca  540
gggctcaga  ttcactgct  cagggtagcc  570



<210> 5985
<211> 303
<212> PRT
<213> Rattus norvegicus
<308> NP_035974
<400> 5985

Met Pro Glu Ala Ser Ser Pro Arg Arg Thr Pro Gln Asn Val Pro Tyr 
  1               5                  10                  15
Gln Asp Leu Pro His Leu Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys 
             20                  25                  30
Arg Tyr Trp Lys Pro Ser Gly Thr Pro Lys Ala Leu Ile Phe Val Ser 
         35                  40                  45
His Gly Ala Gly Glu His Cys Gly Arg Tyr Asp Glu Leu Ala His Met 
     50                  55                  60
Leu Lys Gly Leu Asp Met Leu Val Phe Ala His Asp His Val Gly His 
 65                  70                  75                  80
Gly Gln Ser Glu Gly Glu Arg Met Val Val Ser Asp Phe Gln Val Phe 
                 85                  90                  95
Val Arg Asp Val Leu Gln His Val Asp Thr Ile Gln Lys Asp Tyr Pro 
             100                105                110
Asp Val Pro Ile Phe Leu Leu Gly His Ser Met Gly Gly Ala Ile Ser 
         115                120                125
Ile Leu Val Ala Ala Glu Arg Pro Thr Tyr Phe Ser Gly Met Val Leu 
     130                135                140
Ile Ser Pro Leu Val Leu Ala Asn Pro Glu Ser Ala Ser Thr Leu Lys 
 145                150                155                160
Val Leu Ala Ala Lys Leu Leu Asn Phe Val Leu Pro Asn Met Thr Leu 
                 165                170                175
Gly Arg Ile Asp Ser Ser Val Leu Ser Arg Asn Lys Ser Glu Val Asp 
             180                185                190
Leu Tyr Asn Ser Asp Pro Leu Val Cys Arg Ala Gly Leu Lys Val Cys 
         195                200                205
Phe Gly Ile Gln Leu Leu Asn Ala Val Ala Arg Val Glu Arg Ala Met 
     210                215                220
Pro Arg Leu Thr Leu Pro Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg 
 225                230                235                240
Leu Cys Asp Ser Lys Gly Ala Tyr Leu Leu Met Glu Ser Ser Arg Ser 
                 245                250                255
Gln Asp Lys Thr Leu Lys Met Tyr Glu Gly Ala Tyr His Val Leu His 
             260                265                270
Arg Glu Leu Pro Glu Val Thr Asn Ser Val Leu His Glu Val Asn Ser 
         275                280                285
Trp Val Ser His Arg Ile Ala Ala Ala Gly Ala Gly Cys Pro Pro 
     290                295                300



<210> 5986
<211> 533
<212> DNA
<213> Rattus norvegicus
<308> AA892888
<400> 5986

gacaataag  actctggct  tttattgag  gctgctctc  ttctgacgt  tgtctgctc  60
ctgttcctc  gtagttcag  atagagtgt  tggtgggga  ggaggctga  gtggccaag  120
aagggatac  tgccaaggg  gcaccaggg  gaacgttac  atgctgtga  acacggggc  180
tggctggaa  gacacacaa  ggcgagaga  agagagaga  agagagaga  agagagaga  240
agaatgaat  aatgaataa  tgaatgaat  ggggtccta  aagggttgg  ttgggtaag  300
ccagggcct  gcagtctag  tttctgcct  aagagagca  gaagaaagc  tcactgtgg  360
gaaaggctg  agctgatta  tgatcaccc  ggccgtggc  gcggtgctg  gagtctctg  420
tttacctga  ccctcctta  aagtactgg  gtgggttct  gctgcacat  gggagatca  480
atggccttc  tgggggaga  ttatttcac  gttttcccc  tgatgtggg  ccc  533



<210> 5987
<211> 508
<212> DNA
<213> Rattus norvegicus
<308> AA892895
<400> 5987

cagggctga  aacgagtct  tattgtccc  actacttga  ggggataaa  cgggaggag  60
gggtggcac  aatgccggg  cggccgtgc  tcacaggct  gtaggtgat  gagaactcg  120
ccaggtagt  gccgatcat  tcgggtttg  tctccacct  gttgaaggt  ttgccgttg  180
acacaccca  catgctgcc  accatctcg  gcagaatga  catgtccct  aggtgggtc  240
tcacgacct  cggcttctc  atgggtggc  cctccttct  ggccttcct  aagcgcttg  300
gcagtgagt  ctgcttcct  cgcaggcct  ggttcaggc  ccgtctctg  cgggcgctg  360
acaactgca  cagctgctc  taggacatg  ccagcagct  gtcgaggtc  acgccacgg  420
aggtgaact  gcggaaggt  cgctttttc  tctgctcca  ttcggccat  ttggcggct  480
ctgggaaaa  gaagcggtg  cagcggtt  508



<210> 5988
<211> 144
<212> PRT
<213> Rattus norvegicus
<308> P11174
<400> 5988

Ala Glu Val Glu Gln Lys Lys Lys Arg Thr Phe Arg Lys Phe Thr Tyr 
  1               5                  10                  15
Arg Gly Val Asp Leu Asp Gln Leu Leu Asp Met Ser Tyr Glu Gln Leu 
             20                  25                  30
Met Gln Leu Tyr Ser Ala Arg Gln Arg Arg Arg Leu Asn Arg Gly Leu 
         35                  40                  45
Arg Arg Lys Gln His Ser Leu Leu Lys Arg Leu Arg Lys Ala Lys Lys 
     50                  55                  60
Glu Ala Pro Pro Met Glu Lys Pro Glu Val Val Lys Thr His Leu Arg 
 65                  70                  75                  80
Asp Met Ile Ile Leu Pro Glu Met Val Gly Ser Met Val Gly Val Tyr 
                 85                  90                  95
Asn Gly Lys Thr Phe Asn Gln Val Glu Ile Lys Pro Glu Met Ile Gly 
             100                105                110
His Tyr Leu Gly Glu Phe Ser Ile Thr Tyr Lys Pro Val Lys His Gly 
         115                120                125
Arg Pro Gly Ile Gly Ala Thr His Ser Ser Arg Phe Ile Pro Leu Lys 
     130                135                140



<210> 5989
<211> 221
<212> DNA
<213> Homo sapiens
<308> AA434279
<400> 5989

cggcagcat  gtgggcgtc  acaacggca  gaccttcaa  caggtggag  tcaagcccg  60
gatgatcgg  cactacctg  gcgagttct  catcaccta  aagcccgta  agcatggcc  120
gcccggcat  ggggccacc  actcctccc  cttcatccc  ctcaagtaa  ggctcagct  180
ataaaggcg  acatgactc  aaaaaaaaa  aaaaaaaaa  c  221



<210> 5990
<211> 144
<212> PRT
<213> Homo sapiens
<308> R3HU15
<400> 5990

Ala Glu Val Glu Gln Lys Lys Lys Arg Thr Phe Arg Lys Phe Thr Tyr 
  1               5                  10                  15
Arg Gly Val Asp Leu Asp Gln Leu Leu Asp Met Ser Tyr Glu Gln Leu 
             20                  25                  30
Met Gln Leu Tyr Ser Ala Arg Gln Arg Arg Arg Leu Asn Arg Gly Leu 
         35                  40                  45
Arg Arg Lys Gln His Ser Leu Leu Lys Arg Leu Arg Lys Ala Lys Lys 
     50                  55                  60
Glu Ala Pro Pro Met Glu Lys Pro Glu Val Val Lys Thr His Leu Arg 
 65                  70                  75                  80
Asp Met Ile Ile Leu Pro Glu Met Val Gly Ser Met Val Gly Val Tyr 
                 85                  90                  95
Asn Gly Lys Thr Phe Asn Gln Val Glu Ile Lys Pro Glu Met Ile Gly 
             100                105                110
His Tyr Leu Gly Glu Phe Ser Ile Thr Tyr Lys Pro Val Lys His Gly 
         115                120                125
Arg Pro Gly Ile Gly Ala Thr His Ser Ser Arg Phe Ile Pro Leu Lys 
     130                135                140



<210> 5991
<211> 508
<212> DNA
<213> Rattus norvegicus
<308> AA892895
<400> 5991

cagggctga  aacgagtct  tattgtccc  actacttga  ggggataaa  cgggaggag  60
gggtggcac  aatgccggg  cggccgtgc  tcacaggct  gtaggtgat  gagaactcg  120
ccaggtagt  gccgatcat  tcgggtttg  tctccacct  gttgaaggt  ttgccgttg  180
acacaccca  catgctgcc  accatctcg  gcagaatga  catgtccct  aggtgggtc  240
tcacgacct  cggcttctc  atgggtggc  cctccttct  ggccttcct  aagcgcttg  300
gcagtgagt  ctgcttcct  cgcaggcct  ggttcaggc  ccgtctctg  cgggcgctg  360
acaactgca  cagctgctc  taggacatg  ccagcagct  gtcgaggtc  acgccacgg  420
aggtgaact  gcggaaggt  cgctttttc  tctgctcca  ttcggccat  ttggcggct  480
ctgggaaaa  gaagcggtg  cagcggtt  508



<210> 5992
<211> 144
<212> PRT
<213> Rattus norvegicus
<308> P11174
<400> 5992

Ala Glu Val Glu Gln Lys Lys Lys Arg Thr Phe Arg Lys Phe Thr Tyr 
  1               5                  10                  15
Arg Gly Val Asp Leu Asp Gln Leu Leu Asp Met Ser Tyr Glu Gln Leu 
             20                  25                  30
Met Gln Leu Tyr Ser Ala Arg Gln Arg Arg Arg Leu Asn Arg Gly Leu 
         35                  40                  45
Arg Arg Lys Gln His Ser Leu Leu Lys Arg Leu Arg Lys Ala Lys Lys 
     50                  55                  60
Glu Ala Pro Pro Met Glu Lys Pro Glu Val Val Lys Thr His Leu Arg 
 65                  70                  75                  80
Asp Met Ile Ile Leu Pro Glu Met Val Gly Ser Met Val Gly Val Tyr 
                 85                  90                  95
Asn Gly Lys Thr Phe Asn Gln Val Glu Ile Lys Pro Glu Met Ile Gly 
             100                105                110
His Tyr Leu Gly Glu Phe Ser Ile Thr Tyr Lys Pro Val Lys His Gly 
         115                120                125
Arg Pro Gly Ile Gly Ala Thr His Ser Ser Arg Phe Ile Pro Leu Lys 
     130                135                140



<210> 5993
<211> 221
<212> DNA
<213> Homo sapiens
<308> AA434279
<400> 5993

cggcagcat  gtgggcgtc  acaacggca  gaccttcaa  caggtggag  tcaagcccg  60
gatgatcgg  cactacctg  gcgagttct  catcaccta  aagcccgta  agcatggcc  120
gcccggcat  ggggccacc  actcctccc  cttcatccc  ctcaagtaa  ggctcagct  180
ataaaggcg  acatgactc  aaaaaaaaa  aaaaaaaaa  c  221



<210> 5994
<211> 144
<212> PRT
<213> Homo sapiens
<308> R3HU15
<400> 5994

Ala Glu Val Glu Gln Lys Lys Lys Arg Thr Phe Arg Lys Phe Thr Tyr 
  1               5                  10                  15
Arg Gly Val Asp Leu Asp Gln Leu Leu Asp Met Ser Tyr Glu Gln Leu 
             20                  25                  30
Met Gln Leu Tyr Ser Ala Arg Gln Arg Arg Arg Leu Asn Arg Gly Leu 
         35                  40                  45
Arg Arg Lys Gln His Ser Leu Leu Lys Arg Leu Arg Lys Ala Lys Lys 
     50                  55                  60
Glu Ala Pro Pro Met Glu Lys Pro Glu Val Val Lys Thr His Leu Arg 
 65                  70                  75                  80
Asp Met Ile Ile Leu Pro Glu Met Val Gly Ser Met Val Gly Val Tyr 
                 85                  90                  95
Asn Gly Lys Thr Phe Asn Gln Val Glu Ile Lys Pro Glu Met Ile Gly 
             100                105                110
His Tyr Leu Gly Glu Phe Ser Ile Thr Tyr Lys Pro Val Lys His Gly 
         115                120                125
Arg Pro Gly Ile Gly Ala Thr His Ser Ser Arg Phe Ile Pro Leu Lys 
     130                135                140



<210> 5995
<211> 574
<212> DNA
<213> Rattus norvegicus
<308> AA892919
<400> 5995

ccggccgcc  aacattttt  ttttctttt  ttttttttt  ttttttttt  gaaatgcaa  60
agctcgctt  taataacaa  atacaaaat  tagggaaaa  cccaagtag  gcccactcc  120
agagaccaa  gaatggaac  agatgggag  catgctccc  tgcctgctc  ccagccccg  180
ggggctgaa  tctacatcc  cagctgagt  ctctggatc  ggggcacta  ccccaacag  240
aacaggagg  ccagcttcc  gtttattcc  gttgggtag  ggaggcctc  gctagagca  300
actgccagg  tgaggcttg  gctgatgac  cacatggcc  cttgcaccc  ccaaggaca  360
tgcagactc  tgagcagcc  ggtctcctc  ctgcctagg  agccaggct  aagacaagc  420
cagcatgct  atcaaagca  ggggcaaag  ggacagcac  agcctcgct  taagctctg  480
ctcagggtg  ttctgccta  aaccttccc  gaaggattc  accccggtc  ccatcagac  540
tccctcagc  gaagtaccc  cccactttc  ttca  574



<210> 5996
<211> 704
<212> PRT
<213> Rattus norvegicus
<308> P41777
<400> 5996

Met Ala Asp Thr Gly Leu Arg Arg Val Val Pro Ser Asp Leu Tyr Pro 
  1               5                  10                  15
Leu Val Leu Gly Phe Leu Arg Asp Asn Gln Leu Ser Glu Val Ala Ser 
             20                  25                  30
Lys Phe Ala Lys Ala Thr Gly Ala Thr Gln Gln Asp Ala Asn Ala Ser 
         35                  40                  45
Ser Leu Leu Asp Ile Tyr Ser Phe Trp Leu Lys Ser Thr Lys Ala Pro 
     50                  55                  60
Lys Val Lys Leu Gln Ser Asn Gly Pro Val Ala Lys Lys Ala Lys Lys 
 65                  70                  75                  80
Glu Thr Ser Ser Ser Asp Ser Ser Glu Asp Ser Ser Glu Glu Glu Asp 
                 85                  90                  95
Lys Ala Gln Val Pro Thr Gln Lys Ala Ala Ala Pro Ala Lys Arg Ala 
             100                105                110
Ser Leu Pro Gln His Ala Gly Lys Ala Ala Ala Lys Ala Ser Glu Ser 
         115                120                125
Ser Ser Ser Glu Glu Ser Ser Glu Glu Glu Glu Glu Lys Asp Lys Lys 
     130                135                140
Lys Lys Pro Val Gln Gln Lys Ala Val Lys Pro Gln Ala Lys Ala Val 
 145                150                155                160
Arg Pro Pro Pro Lys Lys Ala Glu Ser Ser Glu Ser Glu Ser Asp Ser 
                 165                170                175
Ser Ser Glu Asp Glu Ala Pro Gln Thr Gln Lys Pro Lys Ala Ala Ala 
             180                185                190
Thr Ala Ala Lys Ala Pro Thr Lys Ala Gln Thr Lys Ala Pro Ala Lys 
         195                200                205
Pro Gly Pro Pro Ala Lys Ala Gln Pro Lys Ala Ala Asn Gly Lys Ala 
     210                215                220
Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Asp Ser Glu 
 225                230                235                240
Glu Glu Lys Lys Ala Ala Ala Pro Leu Lys Lys Thr Ala Pro Lys Lys 
                 245                250                255
Gln Val Val Ala Lys Ala Pro Val Lys Val Thr Ala Ala Pro Thr Gln 
             260                265                270
Lys Ser Ser Ser Ser Glu Asp Ser Ser Ser Glu Glu Glu Glu Glu Gln 
         275                280                285
Lys Lys Pro Met Lys Lys Lys Ala Gly Pro Tyr Ser Ser Val Pro Pro 
     290                295                300
Pro Ser Val Ser Leu Ser Lys Lys Ser Val Gly Ala Gln Ser Pro Lys 
 305                310                315                320
Lys Ala Ala Ala Gln Thr Gln Pro Ala Asp Ser Ser Ala Asp Ser Ser 
                 325                330                335
Glu Glu Ser Asp Ser Ser Ser Glu Glu Glu Lys Lys Thr Pro Ala Lys 
             340                345                350
Thr Val Val Ser Lys Thr Pro Ala Lys Pro Ala Pro Val Lys Lys Lys 
         355                360                365
Ala Glu Ser Ser Ser Asp Ser Ser Asp Ser Asp Ser Ser Glu Asp Glu 
     370                375                380
Ala Pro Ala Lys Pro Val Ser Ala Thr Lys Ser Pro Leu Ser Lys Pro 
 385                390                395                400
Ala Val Thr Pro Lys Pro Pro Ala Ala Lys Ala Val Ala Thr Pro Lys 
                 405                410                415
Gln Pro Ala Gly Ser Gly Gln Lys Pro Gln Ser Arg Lys Ala Asp Ser 
             420                425                430
Ser Ser Ser Glu Glu Glu Ser Ser Ser Ser Glu Glu Glu Ala Thr Lys 
         435                440                445
Lys Ser Val Thr Thr Pro Lys Ala Arg Val Thr Ala Lys Ala Ala Pro 
     450                455                460
Ser Leu Pro Ala Lys Gln Ala Pro Arg Ala Gly Gly Asp Ser Ser Ser 
 465                470                475                480
Asp Ser Glu Ser Ser Ser Ser Glu Glu Glu Lys Lys Thr Pro Pro Lys 
                 485                490                495
Pro Pro Ala Lys Lys Lys Ala Ala Gly Ala Ala Val Pro Lys Pro Thr 
             500                505                510
Pro Val Lys Lys Ala Ala Ala Glu Ser Ser Ser Ser Ser Ser Ser Ser 
         515                520                525
Glu Asp Ser Ser Glu Glu Glu Lys Lys Lys Pro Lys Ser Lys Ala Thr 
     530                535                540
Pro Lys Pro Gln Ala Gly Lys Ala Asn Gly Val Pro Ala Ser Gln Asn 
 545                550                555                560
Gly Lys Ala Gly Lys Glu Ser Glu Glu Glu Glu Glu Asp Thr Glu Gln 
                 565                570                575
Asn Lys Lys Ala Ala Gly Thr Lys Pro Gly Ser Gly Lys Lys Arg Lys 
             580                585                590
His Asn Glu Thr Ala Asp Glu Ala Ala Thr Pro Gln Ser Lys Lys Val 
         595                600                605
Lys Leu Gln Thr Pro Asn Thr Phe Pro Lys Arg Lys Lys Gly Glu Lys 
     610                615                620
Arg Ala Ser Ser Pro Phe Arg Arg Val Arg Glu Glu Glu Ile Glu Val 
 625                630                635                640
Asp Ser Arg Val Ala Asp Asn Ser Phe Asp Ala Lys Arg Gly Ala Ala 
                 645                650                655
Gly Asp Trp Gly Glu Arg Ala Asn Gln Val Leu Lys Phe Thr Lys Gly 
             660                665                670
Lys Ser Phe Arg His Glu Lys Thr Lys Lys Lys Arg Gly Ser Tyr Arg 
         675                680                685
Gly Gly Ser Ile Ser Val Gln Val Asn Ser Val Lys Phe Asp Ser Glu 
     690                695                700



<210> 5997
<211> 574
<212> DNA
<213> Rattus norvegicus
<308> AA892919
<400> 5997

ccggccgcc  aacattttt  ttttctttt  ttttttttt  ttttttttt  gaaatgcaa  60
agctcgctt  taataacaa  atacaaaat  tagggaaaa  cccaagtag  gcccactcc  120
agagaccaa  gaatggaac  agatgggag  catgctccc  tgcctgctc  ccagccccg  180
ggggctgaa  tctacatcc  cagctgagt  ctctggatc  ggggcacta  ccccaacag  240
aacaggagg  ccagcttcc  gtttattcc  gttgggtag  ggaggcctc  gctagagca  300
actgccagg  tgaggcttg  gctgatgac  cacatggcc  cttgcaccc  ccaaggaca  360
tgcagactc  tgagcagcc  ggtctcctc  ctgcctagg  agccaggct  aagacaagc  420
cagcatgct  atcaaagca  ggggcaaag  ggacagcac  agcctcgct  taagctctg  480
ctcagggtg  ttctgccta  aaccttccc  gaaggattc  accccggtc  ccatcagac  540
tccctcagc  gaagtaccc  cccactttc  ttca  574



<210> 5998
<211> 704
<212> PRT
<213> Rattus norvegicus
<308> P41777
<400> 5998

Met Ala Asp Thr Gly Leu Arg Arg Val Val Pro Ser Asp Leu Tyr Pro 
  1               5                  10                  15
Leu Val Leu Gly Phe Leu Arg Asp Asn Gln Leu Ser Glu Val Ala Ser 
             20                  25                  30
Lys Phe Ala Lys Ala Thr Gly Ala Thr Gln Gln Asp Ala Asn Ala Ser 
         35                  40                  45
Ser Leu Leu Asp Ile Tyr Ser Phe Trp Leu Lys Ser Thr Lys Ala Pro 
     50                  55                  60
Lys Val Lys Leu Gln Ser Asn Gly Pro Val Ala Lys Lys Ala Lys Lys 
 65                  70                  75                  80
Glu Thr Ser Ser Ser Asp Ser Ser Glu Asp Ser Ser Glu Glu Glu Asp 
                 85                  90                  95
Lys Ala Gln Val Pro Thr Gln Lys Ala Ala Ala Pro Ala Lys Arg Ala 
             100                105                110
Ser Leu Pro Gln His Ala Gly Lys Ala Ala Ala Lys Ala Ser Glu Ser 
         115                120                125
Ser Ser Ser Glu Glu Ser Ser Glu Glu Glu Glu Glu Lys Asp Lys Lys 
     130                135                140
Lys Lys Pro Val Gln Gln Lys Ala Val Lys Pro Gln Ala Lys Ala Val 
 145                150                155                160
Arg Pro Pro Pro Lys Lys Ala Glu Ser Ser Glu Ser Glu Ser Asp Ser 
                 165                170                175
Ser Ser Glu Asp Glu Ala Pro Gln Thr Gln Lys Pro Lys Ala Ala Ala 
             180                185                190
Thr Ala Ala Lys Ala Pro Thr Lys Ala Gln Thr Lys Ala Pro Ala Lys 
         195                200                205
Pro Gly Pro Pro Ala Lys Ala Gln Pro Lys Ala Ala Asn Gly Lys Ala 
     210                215                220
Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Asp Ser Glu 
 225                230                235                240
Glu Glu Lys Lys Ala Ala Ala Pro Leu Lys Lys Thr Ala Pro Lys Lys 
                 245                250                255
Gln Val Val Ala Lys Ala Pro Val Lys Val Thr Ala Ala Pro Thr Gln 
             260                265                270
Lys Ser Ser Ser Ser Glu Asp Ser Ser Ser Glu Glu Glu Glu Glu Gln 
         275                280                285
Lys Lys Pro Met Lys Lys Lys Ala Gly Pro Tyr Ser Ser Val Pro Pro 
     290                295                300
Pro Ser Val Ser Leu Ser Lys Lys Ser Val Gly Ala Gln Ser Pro Lys 
 305                310                315                320
Lys Ala Ala Ala Gln Thr Gln Pro Ala Asp Ser Ser Ala Asp Ser Ser 
                 325                330                335
Glu Glu Ser Asp Ser Ser Ser Glu Glu Glu Lys Lys Thr Pro Ala Lys 
             340                345                350
Thr Val Val Ser Lys Thr Pro Ala Lys Pro Ala Pro Val Lys Lys Lys 
         355                360                365
Ala Glu Ser Ser Ser Asp Ser Ser Asp Ser Asp Ser Ser Glu Asp Glu 
     370                375                380
Ala Pro Ala Lys Pro Val Ser Ala Thr Lys Ser Pro Leu Ser Lys Pro 
 385                390                395                400
Ala Val Thr Pro Lys Pro Pro Ala Ala Lys Ala Val Ala Thr Pro Lys 
                 405                410                415
Gln Pro Ala Gly Ser Gly Gln Lys Pro Gln Ser Arg Lys Ala Asp Ser 
             420                425                430
Ser Ser Ser Glu Glu Glu Ser Ser Ser Ser Glu Glu Glu Ala Thr Lys 
         435                440                445
Lys Ser Val Thr Thr Pro Lys Ala Arg Val Thr Ala Lys Ala Ala Pro 
     450                455                460
Ser Leu Pro Ala Lys Gln Ala Pro Arg Ala Gly Gly Asp Ser Ser Ser 
 465                470                475                480
Asp Ser Glu Ser Ser Ser Ser Glu Glu Glu Lys Lys Thr Pro Pro Lys 
                 485                490                495
Pro Pro Ala Lys Lys Lys Ala Ala Gly Ala Ala Val Pro Lys Pro Thr 
             500                505                510
Pro Val Lys Lys Ala Ala Ala Glu Ser Ser Ser Ser Ser Ser Ser Ser 
         515                520                525
Glu Asp Ser Ser Glu Glu Glu Lys Lys Lys Pro Lys Ser Lys Ala Thr 
     530                535                540
Pro Lys Pro Gln Ala Gly Lys Ala Asn Gly Val Pro Ala Ser Gln Asn 
 545                550                555                560
Gly Lys Ala Gly Lys Glu Ser Glu Glu Glu Glu Glu Asp Thr Glu Gln 
                 565                570                575
Asn Lys Lys Ala Ala Gly Thr Lys Pro Gly Ser Gly Lys Lys Arg Lys 
             580                585                590
His Asn Glu Thr Ala Asp Glu Ala Ala Thr Pro Gln Ser Lys Lys Val 
         595                600                605
Lys Leu Gln Thr Pro Asn Thr Phe Pro Lys Arg Lys Lys Gly Glu Lys 
     610                615                620
Arg Ala Ser Ser Pro Phe Arg Arg Val Arg Glu Glu Glu Ile Glu Val 
 625                630                635                640
Asp Ser Arg Val Ala Asp Asn Ser Phe Asp Ala Lys Arg Gly Ala Ala 
                 645                650                655
Gly Asp Trp Gly Glu Arg Ala Asn Gln Val Leu Lys Phe Thr Lys Gly 
             660                665                670
Lys Ser Phe Arg His Glu Lys Thr Lys Lys Lys Arg Gly Ser Tyr Arg 
         675                680                685
Gly Gly Ser Ile Ser Val Gln Val Asn Ser Val Lys Phe Asp Ser Glu 
     690                695                700



<210> 5999
<211> 388
<212> DNA
<213> Rattus norvegicus
<308> AA892967
<400> 5999

attgtttgt  aaatgggtg  aatttattg  atatttcct  ataacaaac  aattcagaa  60
ggaatgaat  ttgcagaaa  ccttgccgt  tagcctttc  ttgtcctta  tttgccata  120
ttaaagttc  ataatgtgg  aactccttt  aggagttta  ttggtgaaa  gcagtaaca  180
agtaattaa  aatagcagg  acatctcaa  tagttgata  gtatatgca  aaggcaaac  240
atcaagtga  ttgctcaaa  gggagtgtt  acaggggcc  acggaagtt  acttgctgt  300
gaagggatc  tccgatttg  cttcaaagg  actgacatg  tttggaaag  taagaaatt  360
catctaatt  cttctttta  atgaattt  388



<210> 6000
<211> 465
<212> DNA
<213> Rattus norvegicus
<308> AA892999
<400> 6000

gagtggcag  gatttattg  atactcaca  atacataca  gctgacggc  accctgcct  60
cctagccac  atgtgagta  aaacacagt  cttctggag  ttttatctc  atgcccttc  120
ccctacagt  ggacttctt  gaagtctga  aagtggaag  tcacagaga  ccatgtagt  180
gggagagag  agacaacaa  tatgtatgt  ttgactgag  caaaagagt  ttgaggcca  240
tggtaatcg  gtcctgaac  caaggtcct  cagaaaggt  ttcaccaac  atctgatat  300
acatcaact  tacccttgg  tgtgggcag  ttttccttc  ccttgactc  cttctagat  360
gctggcaca  acagtcagg  ggggctgtg  ttctgcact  ctgacccac  agaagctag  420
gagtaagat  accatccag  catagctcc  gggtcatgg  angaa  465



<210> 6001
<211> 289
<212> DNA
<213> Rattus norvegicus
<308> AA893002
<400> 6001

gagaaggtc  acctgaagg  agtgccctt  gggaaagac  tctctcatc  ccaggtaca  60
caaccatta  tctcagcga  gtacaaagg  acacacatc  gtgacttcc  tacaataaa  120
acagagtca  gcatcccac  cgagaaggc  ccgaaactg  tcacttagt  ctcatagaa  180
ttattagct  cattaacaa  gccacccaa  ttatctgta  aaggaaatg  aacaatata  240
tccaaaggt  aaaacacat  agaacatct  taaaatagt  tgcaataaa  289



<210> 6002
<211> 901
<212> DNA
<213> Homo sapiens
<308> BG261086
<400> 6002

ccttacatt  gaaaaggta  tttaaattt  gccttgccg  attatttaa  atacctttt  60
caatgtaag  gacaaaagg  actatactg  tgtccctta  attggaaaa  gtattttaa  120
tttagcctt  ccgtattat  tatagttag  aatttacta  atttggtag  ctgttttga  180
actaagcac  tgtgtctga  agatgcaga  aatatctat  tatttatta  acagtgggc  240
ctgtttgct  cagaaaaga  tgaaacttt  aactgctta  cacacttgc  agtgaaata  300
acctgacag  gcagaggtt  taactttgg  tctaattac  tttagtaat  gtaagacaa  360
gtgagtttg  ttgtttaca  gctgtttac  atggcataa  tttaaaaat  tatacaatt  420
agatattta  tgcctacta  tttaaagat  ttttatgtg  tttcacctt  ggaatatat  480
gttacattt  cttgtacag  taattttgg  ggctttgtt  atgtagcta  taattttta  540
gactactaa  tgaccagtt  tcggtgctt  tattgtggg  tgctgatta  gtatttatt  600
tacggaagt  ctgacgtgt  tattttgta  tttggtgaa  gtatggtcg  tcctgatgt  660
catgatgat  aagaatttt  tcccaaggg  actggttga  atcaatctt  tcaaattaa  720
agatgcttt  agaaaaaaa  aaaaagggg  ggctaagat  ccgagggcc  gtttaagcg  780
cccgttctg  aaggggcca  aagcgttat  aaaaggagg  cggaaaacc  ggggaaaat  840
tggtttgga  cctcgcggg  taggacacc  aatcagtaa  gaagtaaac  tgtggatgt  900
a  901



<210> 6003
<211> 365
<212> DNA
<213> Rattus norvegicus
<308> AA893011
<400> 6003

ccgggccaa  atcccccta  ctcttcccc  tccccttct  tacgggtgt  cccctcccc  60
tccttcacc  attgccgcc  tccccgcaa  aatcacgtt  actggggcg  tggtaagac  120
cttaaagct  gtaggcaga  tttttgaag  tgagattta  atggataga  gaggtgaca  180
tcagagaag  actgtgtta  gttgctgga  caatggctc  ttgacagaa  caagaacat  240
accagtatt  ccacttaag  acaaagtaa  catacatat  gacaagatg  agagatgac  300
tagagacag  ataagacgt  cttaaagac  atgttggat  ttaacactc  gacaggctc  360
tgcaa  365



<210> 6004
<211> 367
<212> DNA
<213> Rattus norvegicus
<308> AA893032
<400> 6004

acagtgaca  gaaggctta  aaaggagaa  gaagaagaa  acattggac  cctgagatt  60
acaagggtc  tttttggtc  aagtgctgt  aacattttt  agggagttt  aaggcattt  120
ggtctcagg  tttgttagc  tgccctatt  ccttcttag  cagcagttc  gagcaactc  180
caagctttg  taccatctg  ggtgcatct  ctttctgtg  acttctatt  ctaactcat  240
gttatgctg  tactctctg  tctcccatg  agagtactc  ggaggattt  cttgatctt  300
ccgctccat  gagaacatc  ttaattgta  gaaacatcg  aggttgtct  tatctacag  360
gtaaagg  367



<210> 6005
<211> 479
<212> DNA
<213> Rattus norvegicus
<308> AA893082
<400> 6005

aagacagga  gtcagtccc  gaaaataac  tttactggt  attgccttt  aaactgtgg  60
tttttttta  gttacagaa  atccagttc  gcaccacaa  acaactgta  aaaatctgc  120
tcaccttaa  actgtgcag  aatgccatt  tataactgc  taaatttta  tagcgttct  180
aacagtttt  cgatttttt  tttgtatta  atgcttgca  gttatatct  agtgcaatt  240
agtcccaaa  actttaatt  tggaaaaaa  acatacagt  tgaatgtaa  ataccccta  300
agatataag  aggggcgtt  ccccctttt  atactttgg  tttcaatac  gtccacggt  360
tagcaagaa  tacacatac  caacttata  ttaagttgc  agcacatgc  tcagaagct  420
cttttaaaa  agtcncctt  caaactcta  cccccttaa  atcacaaca  taaacgatt  479



<210> 6006
<211> 369
<212> PRT
<213> Rattus norvegicus
<308> NP_062191
<400> 6006

Met Ala Ser Glu Leu Ala Met Asn Asn Ser Asp Leu Pro Thr Ser Pro 
  1               5                  10                  15
Leu Ala Met Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val 
             20                  25                  30
Lys Lys Glu Pro Val Glu Thr Asp Arg Ile Ile Ser Gln Cys Gly Arg 
         35                  40                  45
Leu Ile Ala Gly Gly Ser Leu Ser Ser Thr Pro Met Ser Thr Pro Cys 
     50                  55                  60
Ser Ser Val Pro Pro Ser Pro Ser Phe Ser Ala Pro Ser Pro Ala Ser 
 65                  70                  75                  80
Gly Ser Glu Gln Lys Ala His Leu Glu Asp Tyr Tyr Trp Met Thr Gly 
                 85                  90                  95
Tyr Pro Gln Gln Leu Asn Pro Glu Ala Leu Gly Phe Ser Pro Glu Asp 
             100                105                110
Ala Val Glu Ala Leu Ile Ser Asn Ser His Gln Leu Gln Gly Gly Phe 
         115                120                125
Asp Gly Tyr Ala Arg Gly Ala Gln Gln Leu Ala Ala Ala Ala Gly Ala 
     130                135                140
Gly Ala Gly Ala Ser Leu Gly Gly Ser Gly Glu Glu Met Gly Pro Ala 
 145                150                155                160
Ala Ala Val Val Ser Ala Val Ile Ala Ala Ala Ala Ala Gln Ser Gly 
                 165                170                175
Gly Ala Pro His Tyr His His His His His His Ala Thr Gly His His 
             180                185                190
His His Pro Thr Ala Gly Ala Pro Gly Ala Ala Gly Ser Ala Ser Ala 
         195                200                205
Ser Ala Ser Gly Ala Gly Gly Ala Gly Gly Gly Gly Pro Ala Ser Ala 
     210                215                220
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Thr Ala Gly Ala Gly Gly 
 225                230                235                240
Ala Leu His Pro His His Ala Ala Gly Gly Leu His Phe Asp Asp Arg 
                 245                250                255
Phe Ser Asp Glu Gln Leu Val Thr Met Ser Val Arg Glu Leu Asn Arg 
             260                265                270
Gln Leu Arg Gly Val Ser Lys Glu Glu Val Ile Arg Leu Lys Gln Lys 
         275                280                285
Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser Cys Arg Phe Lys 
     290                295                300
Arg Val Gln Gln Arg His Val Leu Glu Ser Glu Lys Asn Gln Leu Leu 
 305                310                315                320
Gln Gln Val Asp His Leu Lys Gln Glu Ile Ser Arg Leu Val Arg Glu 
                 325                330                335
Arg Asp Ala Tyr Lys Glu Lys Tyr Glu Lys Leu Val Ser Ser Gly Phe 
             340                345                350
Arg Glu Asn Cys Ser Ser Ser Asp Asn Pro Ser Ser Pro Glu Phe Phe 
         355                360                365
Met 
     370



<210> 6007
<211> 4246
<212> DNA
<213> Homo sapiens
<308> AF055376
<400> 6007

atctttttt  atcttctag  tgtagctcg  gctgcttgt  ggcttggct  cccctcccc  60
ctttgctct  tgcctcgtc  ttccccagg  cttcgctat  ttgcttttt  aaaaaaagg  120
aagaaagaa  taaactccc  cctccctct  ctccagtcg  gctgcacct  tgccttgca  180
tttgcacag  ggtagagag  gcgcgaggg  gagagagga  agaaaaaaa  taataaaga  240
agccaagca  aagaggagg  gagaagcat  aagtgttaa  tcccccgtg  caaggcccg  300
gccgcccgg  cagacgccc  ccgcgcctt  cagccccga  cggacgccg  gcgccgccc  360
gcctgcagc  cgggccggc  acggcgagc  cttccttat  caaagcgcg  cagcagcgc  420
aaggcggga  gccgcgcac  gggccgggc  cctccagct  cgccgccgc  gccaccacc  480
ccgccaccg  agctcgcgg  ggatcttcc  gagcctgaa  ccgccggct  ggcgcgcaa  540
gaggcgagc  caaggaggg  ccggggcga  cgagggagc  cattggcgt  agcaggggg  600
agggagggc  ggcgcgggg  gcgcgggca  ggcgggggg  tgtgtgtgt  agcgcgctt  660
gaggtttcg  gccagccac  gccgcgcaa  ctagaagcg  cccagcccg  caagctggc  720
cacccgctg  ccacccagc  cagcccgct  gcccctctc  tgcagccca  ctggcggag  780
ggcggcggc  gcggcggcg  caggagaat  gcatcagaa  tggcaatga  caactccga  840
ctgcccacc  gtcccctgg  catggaata  gttaatgac  tcgatctga  gaagtttga  900
gtgaaaaag  aaccggtgg  gaccgaccg  atcatcagc  agtgcggcc  tctcatcgc  960
gggggctcg  tgtcctcca  ccccatgag  acgccgtgc  gctcggtgc  cccttcccc  1020
agcttctcg  cgcccagcc  gggctcggg  agcgagcag  aggcgcacc  ggaagacta  1080
tactggatg  ccggctacc  gcagcagct  aaccccgag  cgctgggct  cagccccga  1140
gacgcggtc  aggcgctca  cagcaacag  caccagctc  agggcggct  cgatggcta  1200
gcgcgcggg  cgcagcagc  ggccgcggc  gccggggcc  gtgccggcg  ctccttggg  1260
ggcagcggc  aggagatgg  ccccgcggc  gccgtggtg  ccgccgtga  cgccgcggc  1320
gccgcgcag  gcggcgcgg  cccgcacta  caccaccac  accaccacg  cgccggcca  1380
caccaccac  cgacggccg  cgcgcccgg  gccgcgggc  gcgcggccg  ctcggccgg  1440
ggcgctggg  gcgcgggcg  cggtggccc  gccagcgct  ggggcggcg  cggcggcgg  1500
ggcggcgga  gcggcgggg  cgcggcggg  gcggggggc  ccctgcacc  gcaccacgc  1560
gccggcggc  tgcacttcg  cgaccgctt  tccgacgag  agctggtga  catgtctgt  1620
cgcgagctg  accggcagc  gcgcggggt  agcaaggag  aggtgatcc  gctgaagca  1680
aagaggcgg  ccctgaaaa  ccgcggcta  gcccagtcc  gccgcttca  gagggtgca  1740
cagagacac  tcctggagt  ggagaagaa  cagctgctg  agcaagtcg  ccacctcaa  1800
caggagatc  ccaggctgg  gcgcgagag  gacgcgtac  aggagaaat  cgagaagtt  1860
gtgagcagc  gcttccgag  aaacggctc  agcagcgac  acccgtcct  tcccgagtt  1920
ttcatgtga  tctgacacg  gattccagc  agccaccct  ataagtgct  cgcgggggt  1980
cggctcggg  gtgggcttg  tagttctag  gccatgctc  ccaccacct  accaccccc  2040
cccccaccg  gtttggccc  cttggcccc  tacacacac  caaacccgc  cgcacacac  2100
acacacaca  acacacaca  acacacaca  cccacaccc  gctcgagtt  gtggtggtg  2160
tggctgttt  aaactgggg  gggaatggg  gtctggctc  tggattgcc  atctgaaat  2220
ctccataac  tgctagctt  ttttttttt  tttttttta  acccccccg  cccaccccc  2280
ggacttgca  aatgttcaa  gatctcagc  gagttcttc  tgtgaaacg  tgatcacct  2340
tgaagcctg  atcattcac  tattttttc  tcttcttcc  cttcagttc  tgaactggt  2400
ttcattttc  gtgtgtgtg  gtgttttat  ttgtttgga  ttttttttt  aattttact  2460
ttagagctt  ctgtgcttg  ccacctctt  tccaacctc  accctcact  cttctcaac  2520
catctcttc  gagatgaaa  aaaaaaaaa  gcaaagttt  tttttcttc  cctgagttc  2580
tcagtgaga  tgagcttgc  aaggaaaaa  aaatgtgaa  tgttataga  ttgcagcgt  2640
ccgagttcc  tcgggtttt  tttttagca  tgttatgct  aaatagaga  aaaaatcct  2700
atgaacctt  cacaatcaa  cctgcatca  ccttctggg  gtgacttgt  agttttggc  2760
ttgtgatgc  aaatctgag  gtttagtct  ccattaaaa  aactcattc  catctcatg  2820
attattatg  ttgctactt  gtcttagca  caatgaact  taactgttt  aaagacttt  2880
tggaaaaga  acattatat  aataaaaaa  aaagcctgc  tgctggaca  atatggtat  2940
attattttt  ccttttttt  tccttttgg  ttggaaatg  acgttcgaa  acttatagc  3000
tggcattca  acttttgtt  tattgcctc  tgacttttt  gagtttaga  caaaacagt  3060
caaccgtag  gccttcttc  catgaaatt  tgcatctgc  ccaaaactg  tttgagtta  3120
tcagaactt  aacctccca  tgcactgaa  gcattcctt  tcaaagata  cagaatggg  3180
tacacattt  acctggcaa  cattgaaga  ctcttaatg  tttcttttt  ataagaatg  3240
cgcccactt  ggggactaa  attgtgcta  tgccgagaa  cagtctaaa  tttattttt  3300
aaaaagaga  actgcccca  tatttttgg  ttgttttat  tttatttta  attttttgg  3360
ttttggtca  tgtcaaatg  ggaatgctc  gggtttcta  tatataatt  aattctagt  3420
tttataatc  gttagccca  ttaaaatgt  tgctacaga  aaaggaatg  tatagataa  3480
tttgaaaga  ttaggtctg  ttagctgta  attttttaa  cgattgatg  actaaattg  3540
ttactattg  gatgttaag  ggggtagag  ttgcaaggg  actgtttaa  aaaagtagc  3600
tatacagca  gtgcttgca  cttaaatat  agttgggta  gtgtagtct  tgctatacc  3660
ctgactgta  tgaaaacca  agtattaag  ggggaaacg  ccctgttta  atctgtagg  3720
gtattttac  ttcaaaaat  tatgttttt  tttcttttc  aaattaaag  atttgggac  3780
gaattgcac  aagatataa  ctgcaagca  ataatacaa  aaaaaattg  aaaactgtt  3840
agaacgcta  taaaattta  gcagttata  aaatggcat  actgcacag  tttaagatg  3900
tgcagattt  tttacagtt  tattgtggt  cagaactgg  ttttctgta  cttaaaaaa  3960
atccacagt  ttaaaggca  taatcagta  atgttattt  cagggacta  atcctgtct  4020
taaaaagaa  tgaaaagta  atcttacca  aataaatat  aaaaaatct  gtcagttac  4080
tttctttta  atattttgc  gtgcaaaat  gttttatat  ttgagttac  aactaacca  4140
gcgtgttgt  cctatgtgc  tttctttca  tttcaattc  ggttatatc  agaaaagat  4200
atctacaat  ataaacggc  ttttttttt  attctgtaa  aaaaaa  4246



<210> 6008
<211> 374
<212> PRT
<213> Homo sapiens
<308> AF055376
<400> 6008

Met Ala Ser Glu Leu Ala Met Ser Asn Ser Asp Leu Pro Thr Ser Pro 
  1               5                  10                  15
Leu Ala Met Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val 
             20                  25                  30
Lys Lys Glu Pro Val Glu Thr Asp Arg Ile Ile Ser Gln Cys Gly Arg 
         35                  40                  45
Leu Ile Ala Gly Gly Ser Leu Ser Ser Thr Pro Met Ser Thr Pro Cys 
     50                  55                  60
Ser Ser Val Pro Pro Ser Pro Ser Phe Ser Ala Pro Ser Pro Gly Ser 
 65                  70                  75                  80
Gly Ser Glu Gln Lys Ala His Leu Glu Asp Tyr Tyr Trp Met Thr Gly 
                 85                  90                  95
Tyr Pro Gln Gln Leu Asn Pro Glu Ala Leu Gly Phe Ser Pro Glu Asp 
             100                105                110
Ala Val Glu Ala Leu Ile Ser Asn Ser His Gln Leu Gln Gly Gly Phe 
         115                120                125
Asp Gly Tyr Ala Arg Gly Ala Gln Gln Leu Ala Ala Ala Ala Gly Ala 
     130                135                140
Gly Ala Gly Ala Ser Leu Gly Gly Ser Gly Glu Glu Met Gly Pro Ala 
 145                150                155                160
Ala Ala Val Val Ser Ala Val Ile Ala Ala Ala Ala Ala Gln Ser Gly 
                 165                170                175
Ala Gly Pro His Tyr His His His His His His Ala Ala Gly His His 
             180                185                190
His His Pro Thr Ala Gly Ala Pro Gly Ala Ala Gly Ser Ala Ala Ala 
         195                200                205
Ser Ala Gly Gly Ala Gly Gly Ala Gly Gly Gly Gly Pro Ala Ser Ala 
     210                215                220
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala 
 225                230                235                240
Gly Ala Gly Gly Ala Leu His Pro His His Ala Ala Gly Gly Leu His 
                 245                250                255
Phe Asp Asp Arg Phe Ser Asp Glu Gln Leu Val Thr Met Ser Val Arg 
             260                265                270
Glu Leu Asn Arg Gln Leu Arg Gly Val Ser Lys Glu Glu Val Ile Arg 
         275                280                285
Leu Lys Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser 
     290                295                300
Cys Arg Phe Lys Arg Val Gln Gln Arg His Val Leu Glu Ser Glu Lys 
 305                310                315                320
Asn Gln Leu Leu Gln Gln Val Asp His Leu Lys Gln Glu Ile Ser Arg 
                 325                330                335
Leu Val Arg Glu Arg Asp Ala Tyr Lys Glu Lys Tyr Glu Lys Leu Val 
             340                345                350
Ser Ser Gly Phe Arg Glu Asn Gly Ser Ser Ser Asp Asn Pro Ser Ser 
         355                360                365
Pro Glu Phe Phe Met Ter 
     370



<210> 6009
<211> 479
<212> DNA
<213> Rattus norvegicus
<308> AA893088
<400> 6009

acgatattg  acagtttct  aagctaata  cagagttct  ttgcatgta  atttaaagc  60
tgacaaaat  aaacgtatt  cacaaaaga  attcatatt  cagtactgt  gggatcaga  120
gcaaagagt  tgcacttgt  ggtgatgaa  aatacattc  attcaaaag  ataatctgt  180
tgaataaca  cttcttggc  ataataaat  caggacagg  taagagcaa  acctggagt  240
tacggatac  agacaggtg  tttgtaatg  acgcactta  gaacggtag  gcgctcttg  300
cttggcagc  gcatcttgc  agctctaca  tcattagac  tttttgagc  ctgcagatg  360
ggctaccct  cattcacca  cccatacct  agcgtgcca  ccgcagtta  tgcccattt  420
cccctgggt  actagtacc  atgttcaag  aaggtttca  atcagccgt  cctttaatt  479



<210> 6010
<211> 634
<212> DNA
<213> Rattus norvegicus
<308> AA893172
<400> 6010

aagataatt  aactccagc  ctaaagcca  tgggtgtta  ttcttgacc  aagagattt  60
ttaaccatc  aagcagtat  ttgtttcag  tcttagagt  tatctttgt  acttcagat  120
tagagtgga  aatacctca  gtactataa  ttgaagtta  tgttctctc  gtttatctc  180
agaaaagtt  ttgctgata  tcactacaa  ttaaattct  agtggagga  agtgcagta  240
gtaagtcaa  ggaaacctt  tatgatagc  cacctaata  aagtttgaa  actatttta  300
taaatttat  tagctagtc  agtgatgag  ataaatatt  atatccaat  atttttata  360
aagaaatct  ttattagca  tcataatta  gcctgtcac  aagaaagta  tcatacttg  420
attttaatt  atttaaatc  aattcatct  gaatatcta  tattaatta  taccagtca  480
tgataccca  cttcatttc  tagtagaat  atatgggag  tttcctgaa  ttgagtcat  540
cttcagtct  tccaaaacc  cttccagtg  gtctcactg  agttagagt  cagggcaac  600
gctctaaat  agttcagta  aggtccttt  ctct  634



<210> 6011
<211> 2712
<212> DNA
<213> Homo sapiens
<308> AK023165
<400> 6011

ttttaatgg  gctcatata  actgtattt  ttgttgttt  gttttactt  ttgagagtg  60
cacaacatg  atcacataa  catgatttt  tttttttac  tttactccc  aaattattc  120
tgtttctta  atcgtagtc  ttgagaagt  ccaataact  taaactttt  agttataac  180
tagtaaact  ctctttcat  tttgtgtta  ctctgtagt  ttaacctgg  ttttaattt  240
tttgtttcc  aagtcacaa  tgaattatt  ttagatacc  taagccact  aattcagtt  300
tgtttgact  aaagcaaaa  aacgtgaca  tttattttc  aacactaac  tcttgatat  360
ttgttatgg  atatctttt  attaaatat  tattttgac  aagctttca  aaaatattt  420
aagctattt  aatcatcaa  tatggaaaa  aaattacta  tgcattttc  tatatatgc  480
tatattatg  attaaccag  attgtatca  ttttggcct  atgtctgga  ataaaagat  540
attagccta  tatagtatt  ataaatttt  cagttggtt  gggcaaatt  aaacctgaa  600
aataggtta  aaagtagtt  caaattaaa  ttactaatt  atacctgat  ttttttctt  660
aattaaagt  cattttaaa  gagctttat  ataccttaa  aagttggtt  taatttaaa  720
tatgaaagc  ctggctatc  tcctgggat  gtaatttct  attatatag  atttcaaaa  780
tatatattt  ttagttcct  tgagataac  aatttctaa  tatatatgt  tcaaaaacc  840
tatcctgta  tttttttaa  aattgtttt  taaataggt  ataagatac  aggtctgca  900
tagaagacc  actcttact  ggttcccta  ggatctgcc  tagattttt  ttttttttt  960
tttttttta  gtagtttaa  gcaagcact  ataccagtg  gagttggtc  tgatctagg  1020
gattctgtt  agcatccaa  aacaatgcc  aatttcagt  cttaggtta  ggcttgtga  1080
tccagataa  agatggaga  tacctcatg  actgtgact  gaaaatgaa  tcttaaaat  1140
cttaggctc  ctccatgta  ctttcttaa  gaaaagttt  tgagtgtga  ctctctttt  1200
ccatagtat  aagtggagg  tagttcaga  aagttaata  gaaatcttt  gtgacagca  1260
actataata  aagtttgag  aatatttta  taaatttat  taattcaaa  gataaaaat  1320
tatcaatgt  atccaatga  ttttattaa  aaattacct  attattaga  ctgtgccta  1380
tacataaaa  gtgctcatg  atttgaatt  taaataatt  atttaaatc  agaccacca  1440
aagtcatta  taatttaat  attgtttta  atcagtggt  ttcaaccct  acttcatat  1500
agaatcatc  gaggacttt  aatatggaa  ccacctcat  acaattaag  ctaaatttc  1560
ggaagatgg  gccatgctt  tttttccaa  agctctttg  gtgattcta  tttgtagtc  1620
gagttgaag  ccactgctc  aaattagtg  aggaaaatg  ttttatttc  cccatgtta  1680
cttttaaaa  tagtaatgt  cccagttaa  ttttgatgg  ttaaattcc  ctaaagaac  1740
tattcttct  ataactagc  tttattaca  gaaatttaa  agtttaagt  ccatcaaac  1800
agcccttgt  taagattat  atttcttct  tataacttc  aaatagata  ttcattcaa  1860
ctgttcagg  gagaaaaca  aatggattt  ttttttttt  ctctggagc  gcctgttca  1920
tgagatgga  gaggtgggc  catttaagg  cagttcact  acctatggt  cagagttct  1980
atcatatgg  agtttggaa  agagagctt  tcacaggtt  gtatgctgg  gaatggata  2040
ttttaattc  cactgtctc  aaagagaat  agctctcca  cagttctag  aaagctttg  2100
caatcccca  ggggcagtg  taccttact  cttcactgc  tcttagaag  tagaattaa  2160
tttctggaa  tgcacctac  tgttttctt  ttaacattc  gaattggga  tattaattt  2220
tccagtgag  agttttctg  aattggtaa  ttggagagt  aaataacgt  ttttgcttt  2280
caattttgt  tttgtttac  tttatgtaa  aatttgata  gtgaattac  cagttctaa  2340
aaaacctca  gccttttca  tacatctaa  ttgaactct  aacttcatg  tacagaatg  2400
tttaaagat  ctttaatga  aagtattaa  aaaatatat  gatttgtat  tcagtttat  2460
cttcagaaa  ccatatatt  gtcatattt  tttttttag  aacctccta  ttggataac  2520
agatggtat  taaaatgaa  gcccaaaaa  atcttgtac  tttgtccaa  agtttatct  2580
ttggaagcc  ccagccatt  atgtagaga  tttataaga  aataattta  aattgtatg  2640
attttatat  actatggta  ctgtgtacc  tatttctaa  tattcatta  taaattggt  2700
cttcttaaa  cc  2712



<210> 6012
<211> 491
<212> DNA
<213> Rattus norvegicus
<308> AA893183
<400> 6012

tctcaacct  tcagaaaga  aaacaaatc  ccgacaaca  gggtggggc  ttgaccttt  60
gaggactgg  atgcttttc  ccttttgct  tgaggaata  aactaaaaa  tatgtcact  120
agtaaaaat  aaagtgggg  gaaaataat  ctctgggta  acagctttt  tgatatttt  180
tatgttgtt  ttccttaac  gtcactttc  ttttttttt  ttttttcat  tttttcttt  240
ttaaaaaga  acccgagtt  ctttcaaga  taagcatat  acttaaccc  tagaaaatt  300
ggcaggatg  catgttgat  gaataggga  tggtttagg  gacaggaaa  taagctaca  360
cttgtagcc  ctgtccaaa  ggaatgtgc  ttcagcagg  cctgtgaga  ctaatgtga  420
gagagacac  acatgtgag  tgggacttg  tgtgtgagg  atggagtca  tggagactc  480
tccctcgtg  c  491



<210> 6013
<211> 491
<212> DNA
<213> Rattus norvegicus
<308> AA893183
<400> 6013

tctcaacct  tcagaaaga  aaacaaatc  ccgacaaca  gggtggggc  ttgaccttt  60
gaggactgg  atgcttttc  ccttttgct  tgaggaata  aactaaaaa  tatgtcact  120
agtaaaaat  aaagtgggg  gaaaataat  ctctgggta  acagctttt  tgatatttt  180
tatgttgtt  ttccttaac  gtcactttc  ttttttttt  ttttttcat  tttttcttt  240
ttaaaaaga  acccgagtt  ctttcaaga  taagcatat  acttaaccc  tagaaaatt  300
ggcaggatg  catgttgat  gaataggga  tggtttagg  gacaggaaa  taagctaca  360
cttgtagcc  ctgtccaaa  ggaatgtgc  ttcagcagg  cctgtgaga  ctaatgtga  420
gagagacac  acatgtgag  tgggacttg  tgtgtgagg  atggagtca  tggagactc  480
tccctcgtg  c  491



<210> 6014
<211> 345
<212> PRT
<213> Homo sapiens
<308> S57447
<400> 6014

Ala Met Val Ser Glu Phe Leu Lys Gln Ala Cys Tyr Ile Glu Lys Gln 
  1               5                  10                  15
Glu Gln Glu Tyr Val Gln Ala Val Lys Ser Tyr Lys Gly Gly Pro Gly 
             20                  25                  30
Ser Ala Val Ser Pro Tyr Pro Ser Phe Asn Pro Ser Ser Asp Val Ala 
         35                  40                  45
Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr Ile 
     50                  55                  60
Ile Asp Ile Leu Thr Lys Arg Thr Asn Ala Gln Arg Gln Gln Ile Lys 
 65                  70                  75                  80
Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu Lys 
                 85                  90                  95
Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Met Leu Lys 
             100                105                110
Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys Gly 
         115                120                125
Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Thr Thr Arg Ser 
     130                135                140
Asn Gln Gln Ile Arg Glu Ile Thr Arg Val Tyr Arg Glu Glu Leu Lys 
 145                150                155                160
Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe Arg 
                 165                170                175
Asn Ala Leu Leu Ala Leu Ala Lys Gly Asp Arg Cys Glu Asp Met Ser 
             180                185                190
Val Asn Gln Asp Leu Ala Asp Thr Asp Ala Arg Ala Leu Tyr Glu Ala 
         195                200                205
Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile Leu 
     210                215                220
Thr Thr Arg Ser Tyr Pro His Leu Arg Lys Val Phe Gln Asn Tyr Arg 
 225                230                235                240
Lys Tyr Ser Gln His Asp Met Asn Lys Ala Leu Asp Leu Glu Leu Lys 
                 245                250                255
Gly Asp Ile Glu Lys Cys Leu Thr Thr Ile Val Lys Cys Ala Thr Ser 
             260                265                270
Thr Pro Ala Phe Phe Ala Glu Lys Leu Tyr Glu Ala Met Lys Gly Ala 
         275                280                285
Gly Thr Arg His Lys Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu 
     290                295                300
Ile Asp Met Asn Glu Ile Lys Val Phe Tyr Gln Lys Lys Tyr Gly Ile 
 305                310                315                320
Pro Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu Lys 
                 325                330                335
Ile Leu Val Ala Leu Cys Gly Gly Asn 
             340                345



<210> 6015
<211> 491
<212> DNA
<213> Rattus norvegicus
<308> AA893183
<400> 6015

tctcaacct  tcagaaaga  aaacaaatc  ccgacaaca  gggtggggc  ttgaccttt  60
gaggactgg  atgcttttc  ccttttgct  tgaggaata  aactaaaaa  tatgtcact  120
agtaaaaat  aaagtgggg  gaaaataat  ctctgggta  acagctttt  tgatatttt  180
tatgttgtt  ttccttaac  gtcactttc  ttttttttt  ttttttcat  tttttcttt  240
ttaaaaaga  acccgagtt  ctttcaaga  taagcatat  acttaaccc  tagaaaatt  300
ggcaggatg  catgttgat  gaataggga  tggtttagg  gacaggaaa  taagctaca  360
cttgtagcc  ctgtccaaa  ggaatgtgc  ttcagcagg  cctgtgaga  ctaatgtga  420
gagagacac  acatgtgag  tgggacttg  tgtgtgagg  atggagtca  tggagactc  480
tccctcgtg  c  491



<210> 6016
<211> 491
<212> DNA
<213> Rattus norvegicus
<308> AA893183
<400> 6016

tctcaacct  tcagaaaga  aaacaaatc  ccgacaaca  gggtggggc  ttgaccttt  60
gaggactgg  atgcttttc  ccttttgct  tgaggaata  aactaaaaa  tatgtcact  120
agtaaaaat  aaagtgggg  gaaaataat  ctctgggta  acagctttt  tgatatttt  180
tatgttgtt  ttccttaac  gtcactttc  ttttttttt  ttttttcat  tttttcttt  240
ttaaaaaga  acccgagtt  ctttcaaga  taagcatat  acttaaccc  tagaaaatt  300
ggcaggatg  catgttgat  gaataggga  tggtttagg  gacaggaaa  taagctaca  360
cttgtagcc  ctgtccaaa  ggaatgtgc  ttcagcagg  cctgtgaga  ctaatgtga  420
gagagacac  acatgtgag  tgggacttg  tgtgtgagg  atggagtca  tggagactc  480
tccctcgtg  c  491



<210> 6017
<211> 345
<212> PRT
<213> Homo sapiens
<308> S57447
<400> 6017

Ala Met Val Ser Glu Phe Leu Lys Gln Ala Cys Tyr Ile Glu Lys Gln 
  1               5                  10                  15
Glu Gln Glu Tyr Val Gln Ala Val Lys Ser Tyr Lys Gly Gly Pro Gly 
             20                  25                  30
Ser Ala Val Ser Pro Tyr Pro Ser Phe Asn Pro Ser Ser Asp Val Ala 
         35                  40                  45
Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr Ile 
     50                  55                  60
Ile Asp Ile Leu Thr Lys Arg Thr Asn Ala Gln Arg Gln Gln Ile Lys 
 65                  70                  75                  80
Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu Lys 
                 85                  90                  95
Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Met Leu Lys 
             100                105                110
Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys Gly 
         115                120                125
Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Thr Thr Arg Ser 
     130                135                140
Asn Gln Gln Ile Arg Glu Ile Thr Arg Val Tyr Arg Glu Glu Leu Lys 
 145                150                155                160
Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe Arg 
                 165                170                175
Asn Ala Leu Leu Ala Leu Ala Lys Gly Asp Arg Cys Glu Asp Met Ser 
             180                185                190
Val Asn Gln Asp Leu Ala Asp Thr Asp Ala Arg Ala Leu Tyr Glu Ala 
         195                200                205
Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile Leu 
     210                215                220
Thr Thr Arg Ser Tyr Pro His Leu Arg Lys Val Phe Gln Asn Tyr Arg 
 225                230                235                240
Lys Tyr Ser Gln His Asp Met Asn Lys Ala Leu Asp Leu Glu Leu Lys 
                 245                250                255
Gly Asp Ile Glu Lys Cys Leu Thr Thr Ile Val Lys Cys Ala Thr Ser 
             260                265                270
Thr Pro Ala Phe Phe Ala Glu Lys Leu Tyr Glu Ala Met Lys Gly Ala 
         275                280                285
Gly Thr Arg His Lys Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu 
     290                295                300
Ile Asp Met Asn Glu Ile Lys Val Phe Tyr Gln Lys Lys Tyr Gly Ile 
 305                310                315                320
Pro Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu Lys 
                 325                330                335
Ile Leu Val Ala Leu Cys Gly Gly Asn 
             340                345



<210> 6018
<211> 643
<212> DNA
<213> Rattus norvegicus
<308> AA893184
<400> 6018

acatcagtt  aatgccttc  gtacagcac  agaggttaa  agtggatct  agtaagcaa  60
tgttcttta  tagtcacag  ttgtcatca  acatttatt  ctacaataa  catacaggg  120
agaggaaga  agctcaggc  aaaagcttt  gccttaaat  aatacgcac  tcacccgct  180
catatgaac  cccaaccaa  cgcccggtc  tgaaggcta  gcaagtcgc  tggggttct  240
taagtttgc  ttgaaagtt  caagaaact  ggtagctag  tcatcatca  ccattcggc  300
gtcacttga  atcgtgaca  ttataagct  gtgctgccg  acttggggg  tcccctctt  360
atcctcagt  agtttcagc  ctggacgga  tcttccaac  gccaagata  aggcctgag  420
cgggttaat  actgcagtg  actcatcga  gccaaacat  cccaagttg  aaatactaa  480
agatcctcc  tggtactcc  ccggcaaca  ttttccatc  cttgctttc  ttgacagaa  540
ctttacagc  tcagcgatc  cccgtatgt  cttagcagc  gcatctttt  tgattggtg  600
aattaaacc  ttatctgtt  ccacagcca  tgaaatgtc  aca  643



<210> 6019
<211> 667
<212> DNA
<213> Rattus norvegicus
<308> AA893193
<400> 6019

acaatgtag  aaaatttaa  acatactat  taaacaaca  tatttacat  agaaatcac  60
aggacagtg  catttttca  aaatataaa  taattactg  ttagtcaac  ggtttcaaa  120
gtccacaag  ttacaagaa  aaccatctg  ccccaaatg  gtagggcac  tggactaaa  180
cagcctgga  ccttggcat  gctctcttc  cccaacaca  ctggcctcg  ctaggagac  240
caggtgctg  gcctggacc  cggctcctg  tgacaagtg  gttttggtc  gtaggattc  300
gtgttgctg  gtgtgaaca  ttaggtgaa  cacctttgc  ctgcaaagc  tgatgtatc  360
gtcagacac  ccaggtcag  gcatcagca  cacagtgag  aatgtttgc  ctccctttg  420
ggggcggaa  gaatgacta  acagaggat  aggagggaa  atcaggttg  gctcctgca  480
ctggccaag  ctgagagga  acagtggtc  gcagaggct  catcttcct  ttctagggc  540
acagtgcat  ataggactt  aggccttga  aacactcac  cctaacttc  ccaagtttt  600
ccacctcct  aagaatgag  tgcccaaag  caggctcca  agaactcca  tggtaacaa  660
tgtctgc  667



<210> 6020
<211> 258
<212> DNA
<213> Homo sapiens
<308> AA904277
<400> 6020

ttttttttt  tgttagccc  attctaaaa  tgctcagta  cacttttta  tatacaaga  60
tcaaaagta  agcagtatt  caatgtagg  aaatttaat  catactata  aaacaacat  120
atttacatc  gaaatcact  ggacagtgg  atttttcac  aatataaat  aattactgt  180
tagtcaaca  gttttaaaa  tccacaatt  tacaataaa  aaaaaccat  tgtccccag  240
tgagtgggg  acagatgg  258



<210> 6021
<211> 663
<212> DNA
<213> Rattus norvegicus
<308> AA893217
<400> 6021

aacataaag  tagtgaaat  ttaaggata  ggaggcaat  tatatagcc  cttctattc  60
ttgttcagg  tggagcttt  caaagggca  aggtatgag  tttaacact  gaaaaatac  120
tatgaaact  gtttaaccg  ctgcactta  gaccaggca  agcacaata  atagagaac  180
gcataatct  ttaaaaaga  tgctatatt  taacacatc  ttacgaaag  agcactatc  240
gtgaacaat  tgaaactct  cagtgtggg  agagggaaa  ttaccgtga  aatctgagc  300
ttgtttctg  aacttcttc  cactcatac  tcaacagtc  cagagggag  aagaacgca  360
atctcaaat  caggacaac  aaacacact  ggtcaagta  tttcttggg  tcattcatt  420
tgatcacaa  cctaggttg  tggtaggtg  aggcagaca  gttttgaaa  ctttctcat  480
tccactagt  agggcttct  gatacgaag  catattgga  gcaaactga  taagcagca  540
cgttaatcc  cctctcaac  agtcattgc  taatccata  ctgatttaa  agtttttaa  600
ttgttatgt  gaagaatat  cttcttgaa  agcagtcta  cgtgtagac  tgcactagc  660
agg  663



<210> 6022
<211> 646
<212> DNA
<213> Rattus norvegicus
<308> AA893230
<400> 6022

gagttgcca  gcatttatt  tcaagtcat  atcgtcatc  ttgtgaggt  caaaggctt  60
gagaagtac  gtgggtgag  gggatgacg  tgcagaggc  gcccgtcca  gctgcaaag  120
gctgggtaa  gttagtacg  aaatccaga  agacctcct  ttacaggca  ccagtacat  180
gccacatca  ttattggta  tcaccccct  caggggttg  gccatgtgg  cttactgct  240
tgttcgcca  ctctagact  cccttacaa  aaccttcag  ccaggtttt  aggccccgg  300
ggctgtcat  ctctgctcc  ttgacctcg  ctccctagt  gtctcgcac  ggcagggtg  360
tcctctgga  aaacgtgtc  tatttcact  ggccgttag  ttcgatgcc  gcttccttg  420
aaagctcat  cacttcttt  tgagtgagc  tctctccca  tttcatgag  ttcgaccgc  480
actcagacg  catgatgta  cctttcttc  ccttgtctg  catcagcat  gccagaagg  540
tttctttct  tgggtcctc  tgcttgatt  gcatgtgca  aatggtcag  aaggtggag  600
aatccagtt  tccgttctt  tctattcca  gagtctgca  gtgccg  646



<210> 6023
<211> 984
<212> DNA
<213> Homo sapiens
<308> AF308287
<400> 6023

agggctccc  ggaagaaac  ctggcattt  tccctttgc  tcggcttct  gaggcagag  60
ctctgagcc  agggagagc  ttctgcagc  ccatttcct  aaaaatcca  cctgcccag  120
tggcgggtc  tgagctgtg  tcaggaagc  ggaatctga  cctggtggc  tcgggccca  180
tctccatgg  agccgagca  ttattaccc  ggcctccac  cagcttggc  gactttaga  240
ttgaggctg  aggaaaggg  actgaacgc  gttctggga  cagcaagcc  acgggtagc  300
gcggaggcc  cagaatggc  agtttcttt  ccaagacca  atttaatga  tacaaggat  360
ttcttccct  tatgacagc  gcagagggg  agataaaag  caccgactt  atggtggcc  420
tgaggtgcc  gggggccag  ccgacgcca  gggaggtgc  gcggcacct  cagacccac  480
ggatagacg  aaatggaga  ctggatttc  ccacttttc  gaccattat  cacatgcaa  540
taaaacaag  agacccaaa  aaagaaatt  ttctagcca  gttgatggt  gacaaggag  600
agaaaggtt  cgtcatggc  tccgacctg  ggtcaaaac  cacgagtct  ggggagaag  660
tcacccaca  ggaagtgga  gatcttttc  gggaagcag  tatcgaacc  aatggcaaa  720
tgaagtatg  tgaatttat  cacaagatc  cccttcctg  acgggacta  tgaaggagg  780
gaatgggag  gcctcccct  ggcctgaaa  cttggagca  ttaattttt  ttaaaaagt  840
ttcttttca  ttgggagag  tggcaaaca  agtggcaag  caacattac  caactatag  900
agagaggct  actagcaac  ataatagat  atttcagcc  tggtatgag  agatcttta  960
taaaagatt  gtattgatt  tatt  984



<210> 6024
<211> 514
<212> DNA
<213> Rattus norvegicus
<308> AA893260
<400> 6024

gtaaatcag  ataatcagc  ttaatagtt  ccctttaaa  ttaggaaat  attgatgta  60
caataaaga  gacattcag  atattctgt  agttaactg  aaatgaatc  ggtaaacat  120
acttctgat  tagacaaaa  acaaagtct  cccaccatg  tgataatgg  ctgaacctc  180
gaaactgta  gccagccct  attaaaaga  tttctttcg  gatcatggt  tctcccctg  240
caagtgcag  ccgacagga  caggatgta  atcactcct  agagacaca  ccagaatac  300
gcaaataca  aggcgaatg  cagcagcaa  ccactgaac  gagaatagg  cccccgttg  360
aggaatcag  gaaagaacg  gaagagctt  aaggggctc  agaccccat  tgtacaaca  420
tgccaagca  ccagagctt  cagggacta  gccactacc  aaagactag  catggaatt  480
acctggact  tgacctcat  agtagcaat  cata  514



<210> 6025
<211> 296
<212> DNA
<213> Rattus norvegicus
<308> AA893289
<400> 6025

ggtggtgca  aactttaat  ccaacactt  ggaggcaga  gcaggatga  ctctgtatg  60
tcaaggcca  cctggtcta  atagtgaga  gacccactc  cccccgtac  ccagtgaaa  120
ttctgaggc  gcagctcag  cggcggagt  ctttctggg  atgctcaaa  ccctgggtt  180
gaaatctag  accacatta  acctggcac  ctggcacat  cttataatc  caacattca  240
gaggtaggg  aaagagaaa  tttaaggtc  tgattatat  cttattgag  tcttta  296



<210> 6026
<211> 370
<212> DNA
<213> Rattus norvegicus
<308> AA893320
<400> 6026

gaaaaatag  catttaata  ttaagggag  atagaaatc  tgggtatct  agtttgagc  60
accccaaca  accctgaaa  aggaacacc  tggggttca  aggccaaag  tgcgtgagc  120
gtcctcact  tcccgcctg  gatctacct  gaacttctc  tttgcagcc  aagggccca  180
caggatcga  gcccatgtg  ctacttttc  cactgacgt  tatacaaca  gttatcaga  240
ggcacacaa  tcatagtgc  acagagaaa  gaagtcagg  tacagactg  ctcagaatc  300
ggccagaga  cctgcactt  ctcagtctg  atacacagg  gcatgaatc  cacacctga  360
gactcctgca  370



<210> 6027
<211> 362
<212> DNA
<213> Rattus norvegicus
<308> AA893328
<400> 6027

aaaaaaagg  aaaaaagac  aacctggaa  attttaaaa  caacaaaac  ctagttagt  60
gcttcatgt  acatttcac  accattatg  taaatgttt  cttttctac  gaaacaggg  120
cctttacat  acaactgca  tagtttact  ctagatgtt  aaaattaca  gctagtatt  180
actggaacc  gttgatggt  acatcttga  gttttctga  ctcccacct  aggtacacc  240
ggccctctc  taggaccat  tttgcaggg  aaggggagg  agaggaaat  acagatcaa  300
ttcttaaga  tgtttcact  tcttcgtgg  tttccgttt  ttggagatc  gttcaaaaa  360
tc  362



<210> 6028
<211> 591
<212> PRT
<213> Rattus norvegicus
<308> P35565
<400> 6028

Met Glu Gly Lys Trp Leu Leu Cys Leu Leu Leu Val Leu Gly Thr Ala 
  1               5                  10                  15
Ala Ile Gln Ala His Asp Gly His Asp Asp Asp Met Ile Asp Ile Glu 
             20                  25                  30
Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Ser Lys 
         35                  40                  45
Ser Asp Thr Ser Thr Pro Pro Ser Pro Lys Val Thr Tyr Lys Ala Pro 
     50                  55                  60
Val Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Ser 
 65                  70                  75                  80
Leu Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp 
                 85                  90                  95
Glu Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Asp Glu Met Lys Glu 
             100                105                110
Thr Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys 
         115                120                125
His His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr 
     130                135                140
Lys Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu 
 145                150                155                160
Cys Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Ser Glu Leu Asn 
                 165                170                175
Leu Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro 
             180                185                190
Asp Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys 
         195                200                205
Asn Pro Lys Thr Gly Val Tyr Glu Glu Lys His Ala Lys Arg Pro Asp 
     210                215                220
Ala Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr 
 225                230                235                240
Leu Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser 
                 245                250                255
Val Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn 
             260                265                270
Pro Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp 
         275                280                285
Asp Glu Arg Pro Lys Ile Ala Asp Pro Asp Ala Val Lys Pro Asp Asp 
     290                295                300
Trp Asp Glu Asp Ala Pro Ser Lys Ile Pro Asp Glu Glu Ala Thr Lys 
 305                310                315                320
Pro Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Ile Pro Asp Pro Asp 
                 325                330                335
Ala Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu 
             340                345                350
Ala Pro Gln Ile Ala Asn Pro Lys Cys Glu Ser Ala Pro Gly Cys Gly 
         355                360                365
Val Trp Gln Arg Pro Met Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp 
     370                375                380
Lys Pro Pro Met Ile Asp Asn Pro Asn Tyr Gln Gly Ile Trp Lys Pro 
 385                390                395                400
Arg Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg 
                 405                410                415
Met Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser 
             420                425                430
Asp Ile Phe Phe Asp Asn Phe Ile Ile Ser Gly Asp Arg Arg Val Val 
         435                440                445
Asp Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly 
     450                455                460
Ala Ala Glu Pro Gly Val Val Gly Gln Met Leu Glu Ala Ala Glu Glu 
 465                470                475                480
Arg Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val 
                 485                490                495
Phe Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Ser Asn Ala 
             500                505                510
Met Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Asp Glu 
         515                520                525
Glu Gly Lys Glu Glu Glu Lys Asn Lys Gly Asp Glu Glu Glu Glu Glu 
     530                535                540
Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly Gly 
 545                550                555                560
Thr Gly Ser Gln Asp Glu Glu Asp Ser Lys Pro Lys Ala Glu Glu Asp 
                 565                570                575
Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
             580                585                590



<210> 6029
<211> 4117
<212> DNA
<213> Homo sapiens
<308> L10284
<400> 6029

tccgcctct  tctttactg  ggcgcgggg  aaggtgtgc  ggcgggaag  ggcacgggc  60
cccccgcgg  ccccgggag  ctagagatc  tggaaggga  gtggttgct  tgtatgtta  120
tggtgcttg  aactgctat  gttgaggct  atgatggac  tgatgatga  gtgattgat  180
ttgaggatg  ccttgacga  gtcattgaa  aggtagaag  ctcaaaacc  gataccact  240
ctcctcctt  atctcccaa  gttacttac  aagctccag  tccaacagg  gaagtatat  300
ttgctgatt  ttttgacag  ggaactctg  cagggtgga  tttatccaa  gccaagaaa  360
acgataccg  tgatgaaat  gccaaatat  atggaaagt  ggaggtaga  gaaatgaag  420
agtcaaagc  tccaggtga  aaaggactt  tgttgatgt  tcgggccaa  catcatgcg  480
tctctgcta  actgaacaa  cccttcctg  ttgacacca  gcctctcat  gttcagtat  540
aggttaatt  ccaaaatgg  atagaatgt  gtggtgcct  tgtgaaact  ctttctaaa  600
caccagaac  caacctgga  cagttccat  acaagaccc  ttatacgat  atgtttggt  660
cagataaat  tggagagga  tataaactg  acttcatct  ccgacacaa  aaccccaaa  720
cgggtatct  tgaagaaaa  catgctaag  ggccagatg  agatctgaa  acctatttt  780
ctgataaga  aacacatct  tacacacta  tcttgaatc  agataatag  tttgaaata  840
tggttgacc  atctgtggt  aatagtgga  atctgctca  tgacatgac  cctcctgta  900
atccttcac  tgaaattga  gacccagaa  accggaagc  cgaggattg  gatgaaaga  960
caaaaatcc  agatccaga  gctgtcaag  cagatgact  ggatgaaga  gcccctgct  1020
agattccag  tgaagaggc  acaaaaccc  aaggctggt  agatgatga  cctgagtac  1080
tacctgatc  agacgcaga  aaacctgag  attgggatg  agacatgga  ggagaatgg  1140
aggctcctc  gattgccaa  cctagatgt  agtcagctc  tggatgtgg  gtctggcag  1200
gacctgtga  tgacaaccc  aattataaa  gcaaatgga  gcctcctat  attgacaat  1260
ccagttacc  gggaatctg  aaacccagg  aaataccaa  tccagattt  tttgaagat  1320
tggaacctt  cagaatgac  ccttttagt  ctattggtt  ggagctgtg  tccatgacc  1380
ctgacattt  ttttgacaa  tttatcatt  gtgctgatc  aagaatagt  gatgattgg  1440
ccaatgatg  atggggcct  aagaaagct  ctgatgggg  tgctgagcc  ggcgttgtg  1500
ggcagatga  cgaggcagc  gaagagcgc  cgtggctgt  ggtagtcta  attctaact  1560
tagcccttc  tgtgttcct  gttatcctc  tctgctgtt  tggaaagaa  cagaccagt  1620
gtatggagt  taagaaaac  gatgcacct  aaccggatg  gaaggaaga  gaagaagag  1680
aggaagagg  aaaggacaa  ggagatgag  aggaggaag  agaagagaa  cttgaagag  1740
aacagaaaa  tgatgctga  gaagatggt  gcactgtca  tcaagagga  gaagacaga  1800
aacctaaag  agaggagga  gaaattttg  acagatcac  aagaaacag  aagccacga  1860
gagagtgaa  caatcttaa  agcttgatc  gtgatttct  ctccctcct  ccctgcaag  1920
gtggtccta  gagaggacc  ggcacacct  aggttgaca  tcagaaaac  tcaagacat  1980
accatcagc  ggctccagt  gaacactag  ctgtgtaac  ttaaacatc  agcagtaaa  2040
acttgcagt  gtgatataa  ggaccctgt  tctgtagaa  agaaaacat  taacataat  2100
gttgtgaaa  gtaacatga  gcaaactaa  ttttttttt  ttaacatct  tgtttttaa  2160
atagaatga  agaactttg  cagtcttta  gatcttggc  taatttaat  tattaatct  2220
tttgtgcaa  cataatacc  ccatttaaa  atgttaggg  gatgagttg  agtttttat  2280
atagatttt  tttaaagtt  ggtattgta  aacattcac  cctctgtcc  tcaaaattg  2340
taattacgt  taaagtgca  tcatttgtg  ttagaatct  gttttgttt  cttccatta  2400
tgagttcct  ctaaggaaa  tgaggagag  gactgaata  aagcccaaa  tcatataaa  2460
gttgcgttt  agttgtatt  aaaatagat  tataagaaa  aattctttc  cttgatgtt  2520
gttagacca  aaagtgtgt  tgttctgta  ctcagttcc  agacagctt  ttaggtagt  2580
gaggaggtg  cttcatgtg  cacttgggc  tttatattc  acttgggag  gtcaggcct  2640
tggcttctg  agcaggtgg  ttgttaagg  acgctagca  ggcatggca  gtgagctcc  2700
gaatagatg  cttcatcac  tcttccact  tgtgttgac  ctgttttcc  tacctattt  2760
ctcagatcc  cagctttct  ctcgctatg  attttcttc  cagtgcagc  tgcagtccg  2820
tgctgaaaa  gattataag  cctgcataa  gttaagctt  attgtgatt  cgtgtatgt  2880
tcttctttc  tttaagcag  cccatacct  tccagggtc  aagtacaga  tagaataca  2940
tgatacaaa  tacagaaaa  tactttgat  tttatccat  tcttttact  tgtgtaaag  3000
ctttagaag  ctaattcac  ggcaaacca  tacagaatt  actgcagtt  aacagacta  3060
aagtatttg  gggaggagt  acatgaagc  tgagttatc  gattttttt  gtagctgct  3120
tatatttta  gccttcatt  gcaattcat  taacagttg  gtcataaat  acacaataa  3180
gcagtcctg  tcaaatttt  ttttaacgt  gcttgtaga  tttttaaaa  agtgatctt  3240
ggtttgttt  ttcatgcgg  atgcagatg  gtgctatca  agcctctcc  acaccacta  3300
agtgtaata  tgttattat  actctacac  gaaacgtat  cagagttag  tattatttt  3360
gcttcagtt  ttctttaga  gctttcaaa  gtaccgatg  tactgtttc  tgcactgaa  3420
atataaaca  tccacagtg  ttatattgg  aagatattg  gaaggaaat  tatttgtaa  3480
agatgaagg  tgtatctat  tttttttct  tttaaactg  ttcacttaa  ttcttttga  3540
gatgggatg  atttttctt  ctgttcagt  ctttttcct  ttcatctgt  gttctgtgg  3600
cacagtgac  ttagctaca  agcagactt  cccaaatgt  ttgattaca  ataaacagt  3660
gttacttag  aagacctga  aatatgtct  caggtttct  cttgaagca  atgtgtggg  3720
tcattgcat  tccagaaat  tgcctcctt  acccaccgt  gacagtata  gtcatgcct  3780
actttcttg  agctgagct  taaatcatt  gagcttaaa  tgtcagatc  ttcattgcc  3840
ttccagggt  atttagtaa  gtttgttga  aacaaaaac  ccttttctt  gttcttttt  3900
cagttattt  gaaggtcca  catcctgat  aaatgtctg  cacttaatg  atgaccagc  3960
gcagctttc  gctcttaaa  agacactta  attttgatt  tacatgctg  ttacctgtt  4020
cattgttgt  aaatgccca  tgtccatca  atgtgttcc  ccattttct  atccacaaa  4080
tactcctca  ttttcaatt  gtcatgtta  taaaccc  4117



<210> 6030
<211> 592
<212> PRT
<213> Homo sapiens
<308> P27824
<400> 6030

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
  1               5                  10                  15
Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
             20                  25                  30
Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
         35                  40                  45
Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
     50                  55                  60
Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
 65                  70                  75                  80
Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                 85                  90                  95
Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
             100                105                110
Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
         115                120                125
His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
     130                135                140
Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
 145                150                155                160
Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu 
                 165                170                175
Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp 
             180                185                190
Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn 
         195                200                205
Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala 
     210                215                220
Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu 
 225                230                235                240
Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val 
                 245                250                255
Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro 
             260                265                270
Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp 
         275                280                285
Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp 
     290                295                300
Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro 
 305                310                315                320
Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala 
                 325                330                335
Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala 
             340                345                350
Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val 
         355                360                365
Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys 
     370                375                380
Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg 
 385                390                395                400
Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met 
                 405                410                415
Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp 
             420                425                430
Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp 
         435                440                445
Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala 
     450                455                460
Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg 
 465                470                475                480
Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe 
                 485                490                495
Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met 
             500                505                510
Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu 
         515                520                525
Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly 
     530                535                540
Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly 
 545                550                555                560
Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu 
                 565                570                575
Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
             580                585                590



<210> 6031
<211> 519
<212> DNA
<213> Rattus norvegicus
<308> AA893338
<400> 6031

aggaaatgt  catgaaact  aattgttat  ttcaacaaa  agaaagttt  cgtttagct  60
ttgacatag  gatcctgaa  ggaaattca  aggtaccag  cagaactaa  taaacaact  120
cttcatatt  agcctactc  gaaaatctg  aataaaata  atgctgcta  gttttctgg  180
tacaatgac  caaataagt  aaacttgtg  tttgaggag  aggtgtttc  tacaaaatg  240
tgctggaaa  ctgtaaaga  gttactatt  agacaagaa  taagatatt  taaagttta  300
gcatactaa  ttaagtggg  atatgctac  atctcaaag  ggccatgtc  acatggact  360
atccgtgcc  ctgaaaaaa  ggggtctga  catgtgaaa  tttaagcag  acttgtaca  420
accatgtgc  gcataangt  acagctcaa  tctacttta  aaacaaaca  acaaacaaa  480
ataccctct  tccaagctg  cagacttgc  agtaacaag  519



<210> 6032
<211> 1420
<212> DNA
<213> Homo sapiens
<308> BC008045
<400> 6032

ggcacgagg  tgaagcagg  gctcttggc  cggcgcggc  cgctgcaat  cgtggagga  60
cgcgccgcc  agccaccat  atgcctggg  acttacagg  aggcttcgg  tgcgtggtc  120
ccaaccgat  cgaccagtt  tttgacgac  aatcggacc  cttcgaggt  ctgaaggca  180
cagagaaca  gaaaaaaga  gccggcggg  gcggcgttg  gggccctgg  gccaagagc  240
cagctcagg  cgcggccca  accaactcc  acgcggcag  caaacagct  cgcaaggag  300
cccagaaag  ccgcaagaa  ccgctgccc  ccagcgttg  cgtggttga  aagaaagag  360
agacgcagc  gcccgtggc  cttaagaaa  aaggaataa  acgagttgg  agaagacct  420
atcaacaac  tcagggtga  gggaaaata  ttgatagaa  accagaaag  cgaccacct  480
gtgaacgaa  attcgaaaa  ccacttgaa  aaaagggtg  aggaggcga  ttttcagtt  540
atagaccga  tattgaccg  cctattcga  gtcgtggtg  tcttggaag  ggtcgaggg  600
gccgtggac  tggaatggg  cgaggagat  gatttgatt  tcgtggcaa  cgtgaattt  660
ataggcata  tggaagtga  agatcttct  tttcacatt  cagtggcct  aagcacgag  720
acaaacgtg  aggtagcgg  tctcacaac  ggggaactg  caaagacga  ttaacagag  780
cccccaaat  cattcagaa  caaatatct  ataattaca  tgacttgga  caatcaaat  840
tgactgagg  aacacctga  ggtgaagaa  atcatccag  ggcagacac  gaaaataag  900
agaatgaag  tgaagaggt  aaagaggag  gtccaaaag  gatgacttt  gatgagtgg  960
aggctattc  aaataagga  cgggcaaaa  tagaattta  tatccgaaa  ccaaatgaa  1020
gtgctgatg  gcagtggaa  aagggattt  ttcttcata  atcaaagag  gaagaggct  1080
atgctgaag  ttcggttat  gaccatcat  tccggaagc  agcaaatga  ataacgtct  1140
agctggaga  caattttgg  gaccttggc  gcccaggac  tggcggcag  ggaggacga  1200
gtggacgtg  gcgtggtgg  cgcccaaac  gtggcagca  gaccgacaa  tcaagtgct  1260
ctgctcctg  tgtggatga  ccagaggca  tcccagctc  ggcttaact  gatgccata  1320
gacaaccct  gttcctttg  gaacccttc  gttcaaagc  tttgcatgc  taaggattc  1380
aaacgacta  gaaattaaa  aaaaaaaaa  aaaaaaaaaa  1420



<210> 6033
<211> 409
<212> PRT
<213> Homo sapiens
<308> BC008045
<400> 6033

Met Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg 
  1               5                  10                  15
Phe Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys 
             20                  25                  30
Ala Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly 
         35                  40                  45
Pro Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn 
     50                  55                  60
Ala Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn 
 65                  70                  75                  80
Pro Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln 
                 85                  90                  95
Pro Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg 
             100                105                110
Pro Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro 
         115                120                125
Glu Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu 
     130                135                140
Lys Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg 
 145                150                155                160
Pro Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly 
                 165                170                175
Arg Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu 
             180                185                190
Phe Asp Arg His Ser Gly Ser Asp Arg Ser Ser Phe Ser His Tyr Ser 
         195                200                205
Gly Leu Lys His Glu Asp Lys Arg Gly Gly Ser Gly Ser His Asn Trp 
     210                215                220
Gly Thr Val Lys Asp Glu Leu Thr Glu Ser Pro Lys Tyr Ile Gln Lys 
 225                230                235                240
Gln Ile Ser Tyr Asn Tyr Ser Asp Leu Asp Gln Ser Asn Val Thr Glu 
                 245                250                255
Glu Thr Pro Glu Gly Glu Glu His His Pro Val Ala Asp Thr Glu Asn 
             260                265                270
Lys Glu Asn Glu Val Glu Glu Val Lys Glu Glu Gly Pro Lys Glu Met 
         275                280                285
Thr Leu Asp Glu Trp Lys Ala Ile Gln Asn Lys Asp Arg Ala Lys Val 
     290                295                300
Glu Phe Asn Ile Arg Lys Pro Asn Glu Gly Ala Asp Gly Gln Trp Lys 
 305                310                315                320
Lys Gly Phe Val Leu His Lys Ser Lys Ser Glu Glu Ala His Ala Glu 
                 325                330                335
Asp Ser Val Met Asp His His Phe Arg Lys Pro Ala Asn Asp Ile Thr 
             340                345                350
Ser Gln Leu Glu Ile Asn Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly 
         355                360                365
Gly Arg Gly Gly Arg Gly Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg 
     370                375                380
Gly Ser Arg Thr Asp Lys Ser Ser Ala Ser Ala Pro Asp Val Asp Asp 
 385                390                395                400
Pro Glu Ala Phe Pro Ala Leu Ala Ter 
                 405



<210> 6034
<211> 489
<212> DNA
<213> Rattus norvegicus
<308> AA893406
<400> 6034

aatattcta  aatacttta  taattaaga  tggtgggaa  actgatata  aatgtaatt  60
tttatttta  aagattctg  acactggag  agcatctta  cctacaaca  gagaagctt  120
taccctttt  cattatgat  gtaagcttc  aattacaga  agaaacacg  aatcaactt  180
tatatacat  aaaacaaaa  cacgggcta  atgccgccc  aacagatga  gctgcagaa  240
acgaatgag  tgaactgtg  gtcagggcc  ttgatggca  acacaagca  acggggagt  300
aggcttggc  ctgtgaggc  gggaaagca  cagggagac  agacaggca  gcatggtgg  360
tgcctctgt  agccctgta  gcagggggt  gaggcagat  cttggctac  ttgtgaggt  420
acatgagag  ctgtctaat  aaacacaaa  ttaccacag  acaggcagc  caggcccat  480
aagtgctct  489



<210> 6035
<211> 548
<212> DNA
<213> Rattus norvegicus
<308> AA893443
<400> 6035

aaaaaggta  acccatatt  atttactag  actgttaaa  cattacaca  aacacattc  60
agtggcaag  aattataat  caagccctt  cacggcaat  caaatttat  gaactacgg  120
tgctaagtt  tacaaaatt  caccacttt  attaaggct  ttagtttac  tttggccac  180
tcaaagttg  aacatcagg  tggtcaatt  aaatactgt  gctccctgt  ggatggaca  240
acaatcttt  cacccaaac  ttaatgcat  caaagcaac  aggcattgt  aaatagaac  300
gcaagagtt  ctgcagatt  gccttgtga  caattacac  tgattaaaa  tacttccca  360
attcacatc  acagtactc  tccaccatt  aacatctca  ccaaaacgt  acacatgga  420
acagtcact  acaggcgaa  atactaaac  tgtgtattt  gtattgcag  cacacgtgt  480
cacgagcaa  caagggagg  acagtgaga  tctacagct  cagaagcct  aaatgattt  540
caaagttg  548



<210> 6036
<211> 184
<212> PRT
<213> Rattus norvegicus
<308> AAA92787
<400> 6036

Met Arg Glu Tyr Lys Leu Val Val Leu Gly Ser Gly Gly Val Gly Lys 
  1               5                  10                  15
Ser Ala Leu Thr Val Gln Phe Val Gln Gly Ile Phe Val Glu Lys Tyr 
             20                  25                  30
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Glu Val Asp Ala 
         35                  40                  45
Gln Gln Cys Met Leu Glu Ile Leu Asp Ala Ala Gly Thr Glu Gln Phe 
     50                  55                  60
Thr Ala Met Arg Asp Leu Tyr Met Lys Asn Glu Gln Gly Phe Ala Leu 
 65                  70                  75                  80
Val Tyr Ser Ile Thr Thr Gln Ile Asp Cys Asn Asp Leu Gln Gly Leu 
                 85                  90                  95
Arg Glu Gln Ile Leu Arg Val Lys Asp Thr Asp Asp Val Pro Met Ile 
             100                105                110
Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val Val Pro Lys 
         115                120                125
Glu Gln Gly Gln Asn Leu Ala Arg Gln Trp Ser Asn Cys Ala Phe Leu 
     130                135                140
Glu Ser Ser Ala Lys Ser Lys Ile Asn Val Asn Glu Ile Phe Tyr Asp 
 145                150                155                160
Leu Val Arg Gln Ile Asn Arg Lys Thr Pro Val Pro Gly Asn Arg Arg 
                 165                170                175
Lys Lys Ser Pro Cys Gln Leu Leu 
             180



<210> 6037
<211> 1927
<212> DNA
<213> Homo sapiens
<308> NM_015646
<400> 6037

gtaaaccag  cggagcggc  cggcagcgg  aggaccgcc  tggcgccta  agtagcgac  60
cggggggag  gcggggcga  gctggctgc  gggacccgg  gacagcgtg  gaggttcgc  120
gagtactag  ttttgacaa  cttgcatca  gcgtgagta  aagctagtc  ttcttggct  180
aggaggcgt  ggaaagtct  ctttgactg  acaatttgt  caaggaatt  ttgtagaaa  240
atacgatcc  acgatagaa  attcttata  aaagcaagt  gaagtagat  cacaacagt  300
tatgcttga  atcttggat  ctgcaggaa  ggagcaatt  acagcaatg  gggatttat  360
catgaaaaa  ggacaagga  ttgcattag  ttattccat  acagcacag  ccacattta  420
cgatttaca  gacctgaga  aacagattc  tcgagttaa  gacactgat  atgttccaa  480
gattcttgt  ggtaataag  gtgacttgg  agatgaaag  gttgtaggg  aggaacaag  540
tcaaaatct  gcaagacaa  ggaacaact  tgcattctt  gaatcttct  caaaatcaa  600
aataaatgt  aatgagatc  tttatgacc  agtgcggca  attaacaga  aaactccag  660
gcctgggaa  gctcgcaaa  agtcatcat  tcagctgct  taatatact  aatgcattg  720
agctctgag  caggtctga  gaactgttg  ccaattcaa  agtgccagc  ttccaactt  780
gttaaacct  ccaacatct  aaatggact  tcctgtggt  gtacccttt  agaggcgga  840
gaaagctac  atatcagtt  gcacattct  atcactttc  agtatcaca  gagagattt  900
tacttatat  atagtccta  agtttgcag  tggtaaaac  agaggctac  tccagtatt  960
ctgctaaga  acattcttc  tccaccaat  ttgtacatg  atgaaaatg  tgtactgta  1020
actttaaca  gccccatac  ttgtattgg  gagtacaat  atgtaaatc  taaaagcac  1080
actatttta  cataataaa  gaaagtcca  agagctcct  tatagacta  tccagataa  1140
ttcgcttct  tgatacttg  agcttattg  aattttttt  aagaaattc  aggtcatta  1200
tattgtaca  aataagcgc  ttgattaac  cagctatat  gttttttta  tttttaaaa  1260
acctgtgga  acggtgatc  tgtctttaa  acatgatag  cctttcagt  taatgtctt  1320
gattaaaga  gttgccttt  atatctgtt  ggaaggaaa  gtccagact  ttcaaatct  1380
ttattatat  tttcctttt  ttgtttaca  agggaacaa  gtttatagt  gtgtgtaca  1440
tgggggtct  caacaagaa  tgtatattt  caaacaatt  tttaatgat  taacaattt  1500
tgtaaatca  tttcaggct  ctgcagctg  agattctca  tgtgaatcc  ttgcttgct  1560
atgcataag  gtatttgca  taccaaata  acaggttta  tatttttgc  tgttagtga  1620
tgtttcaca  gtgtaacgt  ttggttgag  tgttaaatg  tggacgagt  ctgtggatg  1680
gaatgtggg  agtaatttt  atcatatgt  attggtcac  aggcctaat  tgcagtaac  1740
attgctgtt  tatttaaca  tgccttgtt  ctttgtatg  attaatgtt  ggatgtaaa  1800
attgtgtgt  tatccaaca  ggagccaca  tatttaaat  gaccaacct  atgttacaa  1860
tactttgag  tggccaaat  taaactaaa  gccttaatt  aagtggtgc  attttgtaa  1920
aaaaaaa  1927



<210> 6038
<211> 184
<212> PRT
<213> Homo sapiens
<308> P09526
<400> 6038

Met Arg Glu Tyr Lys Leu Val Val Leu Gly Ser Gly Gly Val Gly Lys 
  1               5                  10                  15
Ser Ala Leu Thr Val Gln Phe Val Gln Gly Ile Phe Val Glu Lys Tyr 
             20                  25                  30
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Glu Val Asp Ala 
         35                  40                  45
Gln Gln Cys Met Leu Glu Ile Leu Asp Thr Ala Gly Thr Glu Gln Phe 
     50                  55                  60
Thr Ala Met Arg Asp Leu Tyr Met Lys Asn Gly Gln Gly Phe Ala Leu 
 65                  70                  75                  80
Val Tyr Ser Ile Thr Ala Gln Ser Thr Phe Asn Asp Leu Gln Asp Leu 
                 85                  90                  95
Arg Glu Gln Ile Leu Arg Val Lys Asp Thr Asp Asp Val Pro Met Ile 
             100                105                110
Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val Val Gly Lys 
         115                120                125
Glu Gln Gly Gln Asn Leu Ala Arg Gln Trp Asn Asn Cys Ala Phe Leu 
     130                135                140
Glu Ser Ser Ala Lys Ser Lys Ile Asn Val Asn Glu Ile Phe Tyr Asp 
 145                150                155                160
Leu Val Arg Gln Ile Asn Arg Lys Thr Pro Val Pro Gly Lys Ala Arg 
                 165                170                175
Lys Lys Ser Ser Cys Gln Leu Leu 
             180



<210> 6039
<211> 410
<212> DNA
<213> Rattus norvegicus
<308> AA893454
<400> 6039

gcttctcag  ttttatttt  atttgggtt  acagcaatc  caaggtgcc  gagcccact  60
tcagtgggc  aagtatact  tagacacag  gaaggtggg  acaccccac  actgacaga  120
ttagaagat  catttggct  cagcatgga  gatctctgg  gtgacattt  ctgacgtct  180
cataagaca  tccccatga  tttctattt  attcgcttc  aagaaactt  ggaaatttc  240
aaataagtg  atggtcaag  ataaaaaaa  atgatcttt  ttaagctgt  tgtataatg  300
gcctggtaa  ttagaggga  atgagtttt  gaaagcagg  tttatgtgg  ataaaaata  360
tgttcattt  cctaagact  ataataaat  ttatggttg  ataaaactta  410



<210> 6040
<211> 354
<212> DNA
<213> Rattus norvegicus
<308> AA893471
<400> 6040

aagcatggg  tttcagcag  gttcagcct  aagtgcagt  ccagtaaag  cgggggctg  60
acgaccatt  cactttgcg  gggttggct  aacttcatc  gaagggatg  ctatgaccc  120
cagggaaac  acccatgaa  agaagaaca  agtgaggaa  acatccacc  tcttacaag  180
cactttgtt  ccacgggca  gaaatggca  ttactgtta  taggtatct  aattaactt  240
ctgcataat  caagtaggt  aaagtccag  agcaaaata  tgcaaccca  caagtagat  300
cagtttcag  gtgttatac  gtggaggag  gtacacaaa  gacaaacaa  gata  354



<210> 6041
<211> 3461
<212> PRT
<213> Rattus norvegicus
<308> NP_035391
<400> 6041

Met Glu Arg Gly Cys Trp Ala Pro Arg Ala Leu Val Leu Ala Val Leu 
  1               5                  10                  15
Leu Leu Leu Ala Thr Leu Arg Ala Arg Ala Ala Thr Gly Tyr Tyr Pro 
             20                  25                  30
Arg Phe Ser Pro Phe Phe Phe Leu Cys Thr His His Gly Glu Leu Glu 
         35                  40                  45
Gly Asp Gly Glu Gln Gly Glu Val Leu Ile Ser Leu His Ile Ala Gly 
     50                  55                  60
Asn Pro Thr Tyr Tyr Val Pro Gly Gln Glu Tyr His Val Thr Ile Ser 
 65                  70                  75                  80
Thr Ser Thr Phe Phe Asp Gly Leu Leu Val Thr Gly Leu Tyr Thr Ser 
                 85                  90                  95
Thr Ser Ile Gln Ser Ser Gln Ser Ile Gly Gly Ser Ser Ala Phe Gly 
             100                105                110
Phe Gly Ile Met Ser Asp His Gln Phe Gly Asn Gln Phe Met Cys Ser 
         115                120                125
Val Val Ala Ser His Val Ser His Leu Pro Thr Thr Asn Leu Ser Phe 
     130                135                140
Val Trp Ile Ala Pro Pro Ala Gly Thr Gly Cys Val Asn Phe Met Ala 
 145                150                155                160
Thr Ala Thr His Arg Gly Gln Val Ile Phe Lys Asp Ala Leu Ala Gln 
                 165                170                175
Gln Leu Cys Glu Gln Gly Ala Pro Thr Glu Ala Thr Ala Tyr Ser His 
             180                185                190
Leu Ala Glu Ile His Ser Asp Ser Val Ile Leu Arg Asp Asp Phe Asp 
         195                200                205
Ser Tyr Gln Gln Leu Glu Leu Asn Pro Asn Ile Trp Val Glu Cys Ser 
     210                215                220
Asn Cys Glu Met Gly Glu Gln Cys Gly Thr Ile Met His Gly Asn Ala 
 225                230                235                240
Val Thr Phe Cys Glu Pro Tyr Gly Pro Arg Glu Leu Thr Thr Thr Cys 
                 245                250                255
Leu Asn Thr Thr Thr Ala Ser Val Leu Gln Phe Ser Ile Gly Ser Gly 
             260                265                270
Ser Cys Arg Phe Ser Tyr Ser Asp Pro Ser Ile Thr Val Ser Tyr Ala 
         275                280                285
Lys Asn Asn Thr Ala Asp Trp Ile Gln Leu Glu Lys Ile Arg Ala Pro 
     290                295                300
Ser Asn Val Ser Thr Val Ile His Ile Leu Tyr Leu Pro Glu Glu Ala 
 305                310                315                320
Lys Gly Glu Ser Val Gln Phe Gln Trp Lys Gln Asp Ser Leu Arg Val 
                 325                330                335
Gly Glu Val Tyr Glu Ala Cys Trp Ala Leu Asp Asn Ile Leu Val Ile 
             340                345                350
Asn Ser Ala His Arg Glu Val Val Leu Glu Asp Asn Leu Asp Pro Val 
         355                360                365
Asp Thr Gly Asn Trp Leu Phe Phe Pro Gly Ala Thr Val Lys His Ser 
     370                375                380
Cys Gln Ser Asp Gly Asn Ser Ile Tyr Phe His Gly Asn Glu Gly Ser 
 385                390                395                400
Glu Phe Asn Phe Ala Thr Thr Arg Asp Val Asp Leu Ser Thr Glu Asp 
                 405                410                415
Ile Gln Glu Gln Trp Ser Glu Glu Phe Glu Ser Gln Pro Thr Gly Trp 
             420                425                430
Asp Ile Leu Gly Ala Val Val Gly Ala Asp Cys Gly Thr Val Glu Ser 
         435                440                445
Gly Leu Ser Leu Val Phe Leu Lys Asp Gly Glu Arg Lys Leu Cys Thr 
     450                455                460
Pro Tyr Met Asp Thr Thr Gly Tyr Gly Asn Leu Arg Phe Tyr Phe Val 
 465                470                475                480
Met Gly Gly Ile Cys Asp Pro Gly Val Ser His Glu Asn Asp Ile Ile 
                 485                490                495
Leu Tyr Ala Lys Ile Glu Gly Arg Lys Glu His Ile Ala Leu Asp Thr 
             500                505                510
Leu Thr Tyr Ser Ser Tyr Lys Val Pro Ser Leu Val Ser Val Val Ile 
         515                520                525
Asn Pro Glu Leu Gln Thr Pro Ala Thr Lys Phe Cys Leu Arg Gln Lys 
     530                535                540
Ser His Gln Gly Tyr Asn Arg Asn Val Trp Ala Val Asp Phe Phe His 
 545                550                555                560
Val Leu Pro Val Leu Pro Ser Thr Met Ser His Met Ile Gln Phe Ser 
                 565                570                575
Ile Asn Leu Gly Cys Gly Thr His Gln Pro Gly Asn Ser Val Ser Leu 
             580                585                590
Glu Phe Ser Thr Asn His Gly Arg Ser Trp Ser Leu Leu His Thr Glu 
         595                600                605
Cys Leu Pro Glu Ile Cys Ala Gly Pro His Leu Pro His Ser Thr Val 
     610                615                620
Tyr Ser Ser Glu Asn Tyr Ser Gly Trp Asn Arg Ile Thr Ile Pro Leu 
 625                630                635                640
Pro Asn Ala Ala Leu Thr Arg Asp Thr Arg Ile Arg Trp Arg Gln Thr 
                 645                650                655
Gly Pro Ile Leu Gly Asn Met Trp Ala Ile Asp Asn Val Tyr Ile Gly 
             660                665                670
Pro Ser Cys Leu Lys Phe Cys Ser Gly Arg Gly Gln Cys Thr Arg His 
         675                680                685
Gly Cys Lys Cys Asp Pro Gly Phe Ser Gly Pro Ala Cys Glu Met Ala 
     690                695                700
Ser Gln Thr Phe Pro Met Phe Ile Ser Glu Ser Phe Gly Ser Ala Arg 
 705                710                715                720
Leu Ser Ser Tyr His Asn Phe Tyr Ser Ile Arg Gly Ala Glu Val Ser 
                 725                730                735
Phe Gly Cys Gly Val Leu Ala Ser Gly Lys Ala Leu Val Phe Asn Lys 
             740                745                750
Asp Gly Arg Arg Gln Leu Ile Thr Ser Phe Leu Asp Ser Ser Gln Ser 
         755                760                765
Arg Phe Leu Gln Phe Thr Leu Arg Leu Gly Ser Lys Ser Val Leu Ser 
     770                775                780
Thr Cys Arg Ala Pro Asp Gln Pro Gly Glu Gly Val Leu Leu His Tyr 
 785                790                795                800
Ser Tyr Asp Asn Gly Ile Thr Trp Lys Leu Leu Glu His Tyr Ser Tyr 
                 805                810                815
Val Asn Tyr His Glu Pro Arg Ile Ile Ser Val Glu Leu Pro Asp Asp 
             820                825                830
Ala Arg Gln Phe Gly Ile Gln Phe Arg Trp Trp Gln Pro Tyr His Ser 
         835                840                845
Ser Gln Gly Glu Asp Val Trp Ala Ile Asp Glu Ile Val Met Thr Ser 
     850                855                860
Val Leu Phe Asn Ser Ile Ser Leu Asp Phe Thr Asn Leu Val Glu Val 
 865                870                875                880
Thr Gln Ser Leu Gly Phe Tyr Leu Gly Asn Val Gln Pro Tyr Cys Gly 
                 885                890                895
His Asp Trp Thr Leu Cys Phe Thr Gly Asp Ser Lys Leu Ala Ser Ser 
             900                905                910
Met Arg Tyr Val Glu Thr Gln Ser Met Gln Ile Gly Ala Ser Tyr Met 
         915                920                925
Ile Gln Phe Ser Leu Val Met Gly Cys Gly Gln Lys Tyr Thr Pro His 
     930                935                940
Met Asp Asn Gln Val Lys Leu Glu Tyr Ser Ala Asn His Gly Leu Thr 
 945                950                955                960
Trp His Leu Val Gln Glu Glu Cys Leu Pro Ser Met Pro Ser Cys Gln 
                 965                970                975
Glu Phe Thr Ser Ala Ser Ile Tyr His Ala Ser Glu Phe Thr Gln Trp 
             980                985                990
Arg Arg Val Thr Val Val Leu Pro Gln Lys Thr Trp Ser Gly Ala Thr 
         995                1000                1005
Arg Phe Arg Trp Ser Gln Ser Tyr Tyr Thr Ala Gln Asp Glu Trp Ala 
     1010                1015                1020
Leu Asp Asn Ile Tyr Ile Gly Gln Gln Cys Pro Asn Met Cys Ser Gly 
 1025                1030                1035                1040
His Gly Ser Cys Asp His Gly Val Cys Arg Cys Asp Gln Gly Tyr Gln 
                 1045                1050                1055
Gly Thr Glu Cys His Pro Glu Ala Ala Leu Pro Ser Thr Ile Met Ser 
             1060                1065                1070
Asp Phe Glu Asn Pro Ser Ser Trp Glu Ser Asp Trp Gln Glu Val Ile 
         1075                1080                1085
Gly Gly Glu Val Val Lys Pro Glu Gln Gly Cys Gly Val Val Ser Ser 
     1090                1095                1100
Gly Ser Ser Leu Tyr Phe Ser Lys Ala Gly Lys Arg Gln Leu Val Ser 
 1105                1110                1115                1120
Trp Asp Leu Asp Thr Ser Trp Val Asp Phe Val Gln Phe Tyr Ile Gln 
                 1125                1130                1135
Ile Gly Gly Glu Ser Ala Ala Cys Asn Lys Pro Asp Ser Arg Glu Glu 
             1140                1145                1150
Gly Ile Leu Leu Gln Tyr Ser Asn Asn Gly Gly Ile Gln Trp His Leu 
         1155                1160                1165
Leu Ala Glu Met Tyr Phe Ser Asp Phe Ser Lys Pro Arg Phe Val Tyr 
     1170                1175                1180
Leu Glu Leu Pro Ala Ala Gly Lys Thr Pro Cys Thr Arg Phe Arg Trp 
 1185                1190                1195                1200
Trp Lys Pro Val Phe Ser Gly Glu Asp Tyr Asp Gln Trp Ala Val Asp 
                 1205                1210                1215
Asp Ile Ile Ile Leu Ser Glu Lys Gln Lys Gln Val Ile Pro Val Val 
             1220                1225                1230
Asn Pro Thr Leu Pro Gln Asn Phe Tyr Glu Lys Pro Ala Phe Asp Tyr 
         1235                1240                1245
Pro Met Asn Gln Met Ser Val Trp Leu Met Leu Ala Asn Glu Gly Met 
     1250                1255                1260
Ala Lys Asn Asp Ser Phe Cys Ala Thr Thr Pro Ser Ala Met Val Phe 
 1265                1270                1275                1280
Gly Lys Ser Asp Gly Asp Arg Phe Ala Val Thr Arg Asp Leu Thr Leu 
                 1285                1290                1295
Lys Pro Gly Tyr Val Leu Gln Phe Lys Leu Asn Ile Gly Cys Thr Ser 
             1300                1305                1310
Gln Phe Ser Ser Thr Ala Pro Val Leu Leu Gln Tyr Ser His Asp Ala 
         1315                1320                1325
Gly Met Ser Trp Phe Leu Leu Lys Glu Gly Cys Phe Pro Ala Ser Ala 
     1330                1335                1340
Ala Lys Gly Cys Glu Gly Asn Ser Arg Glu Leu Ser Glu Pro Thr Val 
 1345                1350                1355                1360
Tyr Tyr Thr Gly Asp Phe Glu Glu Trp Thr Arg Ile Thr Ile Ala Ile 
                 1365                1370                1375
Pro Arg Ser Leu Ala Ser Ser Lys Thr Arg Phe Arg Trp Ile Gln Glu 
             1380                1385                1390
Ser Ser Ser Gln Lys Asn Val Pro Pro Phe Gly Leu Asp Gly Val Tyr 
         1395                1400                1405
Ile Ser Glu Pro Cys Pro Ser Tyr Cys Ser Gly His Gly Asp Cys Ile 
     1410                1415                1420
Ser Gly Val Cys Phe Cys Asp Leu Gly Tyr Thr Ala Ala Gln Gly Thr 
 1425                1430                1435                1440
Cys Val Ser Asn Thr Pro Asn His Ser Glu Met Phe Asp Arg Phe Glu 
                 1445                1450                1455
Gly Lys Leu Ser Pro Leu Trp Tyr Lys Ile Thr Gly Gly Gln Val Gly 
             1460                1465                1470
Thr Gly Cys Gly Thr Leu Asn Asp Gly Arg Ser Leu Tyr Phe Asn Gly 
         1475                1480                1485
Leu Gly Lys Arg Glu Ala Arg Thr Val Pro Leu Asp Thr Arg Asn Ile 
     1490                1495                1500
Ser Leu Val Gln Phe Tyr Ile Gln Ile Gly Ser Lys Thr Ser Gly Ile 
 1505                1510                1515                1520
Thr Tyr Ile Thr Pro Arg Ala Arg Tyr Glu Gly Leu Val Val Gln Tyr 
                 1525                1530                1535
Ser Asn Asp Asn Gly Ile Leu Trp His Leu Leu Arg Glu Leu Asp Phe 
             1540                1545                1550
Met Ser Phe Leu Glu Pro Gln Ile Ile Ser Ile Asp Leu Pro Arg Glu 
         1555                1560                1565
Ala Lys Thr Pro Ala Thr Ala Phe Arg Trp Trp Gln Pro Gln His Gly 
     1570                1575                1580
Lys His Ser Ala Gln Trp Ala Leu Gly Asp Val Leu Ile Gly Val Asn 
 1585                1590                1595                1600
Asp Ser Ser Gln Thr Gly Phe Gln Asp Lys Leu Asp Gly Ser Ile Asp 
                 1605                1610                1615
Leu Gln Ala Asn Trp Tyr Arg Ile Gln Gly Gly Gln Val Asp Ile Asp 
             1620                1625                1630
Cys Leu Ser Met Asp Thr Ala Leu Ile Phe Thr Glu Asn Ile Gly Asn 
         1635                1640                1645
Pro Arg Tyr Ala Glu Thr Trp Asp Phe His Val Ser Glu Ser Ser Phe 
     1650                1655                1660
Leu Gln Trp Glu Met Asn Met Gly Cys Ser Lys Pro Phe Ser Gly Ala 
 1665                1670                1675                1680
His Gly Ile Gln Leu Gln Tyr Ser Leu Asn Asn Gly Lys Asp Trp Gln 
                 1685                1690                1695
Leu Val Thr Glu Glu Cys Val Pro Pro Thr Ile Gly Cys Val His Tyr 
             1700                1705                1710
Thr Glu Ser Ser Thr Tyr Thr Ser Glu Arg Phe Gln Asn Trp Arg Arg 
         1715                1720                1725
Val Thr Val Tyr Leu Pro Leu Ala Thr Asn Ser Pro Arg Thr Arg Phe 
     1730                1735                1740
Arg Trp Ile Gln Thr Asn Tyr Thr Val Gly Ala Asp Ser Trp Ala Ile 
 1745                1750                1755                1760
Asp Asn Val Ile Leu Ala Ser Gly Cys Pro Trp Met Cys Ser Gly Arg 
                 1765                1770                1775
Gly Ile Cys Asp Ser Gly Arg Cys Val Cys Asp Arg Gly Phe Gly Gly 
             1780                1785                1790
Pro Phe Cys Val Pro Val Val Pro Leu Pro Ser Ile Leu Lys Asp Asp 
         1795                1800                1805
Phe Asn Gly Asn Leu His Pro Asp Leu Trp Pro Glu Val Tyr Gly Ala 
     1810                1815                1820
Glu Arg Gly Asn Leu Asn Gly Glu Thr Ile Lys Ser Gly Thr Cys Leu 
 1825                1830                1835                1840
Ile Phe Lys Gly Glu Gly Leu Arg Met Leu Ile Ser Arg Asp Leu Asp 
                 1845                1850                1855
Cys Thr Asn Thr Met Tyr Val Gln Phe Ser Leu Arg Phe Ile Ala Lys 
             1860                1865                1870
Gly Thr Pro Glu Arg Ser His Ser Ile Leu Leu Gln Phe Ser Val Ser 
         1875                1880                1885
Gly Gly Val Thr Trp His Leu Met Asp Glu Phe Tyr Phe Pro Gln Thr 
     1890                1895                1900
Thr Ser Ile Leu Phe Ile Asn Val Pro Leu Pro Tyr Gly Ala Gln Thr 
 1905                1910                1915                1920
Asn Ala Thr Arg Phe Arg Leu Trp Gln Pro Tyr Asn Asn Gly Lys Lys 
                 1925                1930                1935
Glu Glu Ile Trp Ile Ile Asp Asp Phe Ile Ile Asp Gly Asn Asn Leu 
             1940                1945                1950
Asn Asn Pro Val Leu Leu Leu Asp Thr Phe Asp Phe Gly Pro Arg Glu 
         1955                1960                1965
Asp Asn Trp Phe Phe Tyr Pro Gly Gly Asn Ile Gly Leu Tyr Cys Pro 
     1970                1975                1980
Tyr Ser Ser Lys Gly Ala Pro Glu Glu Asp Ser Ala Met Val Phe Val 
 1985                1990                1995                2000
Ser Asn Glu Val Gly Glu His Ser Ile Thr Thr Arg Asp Leu Ser Val 
                 2005                2010                2015
Asn Glu Asn Thr Ile Ile Gln Phe Glu Ile Asn Val Gly Cys Ser Thr 
             2020                2025                2030
Asp Ser Ser Ser Ala Asp Pro Val Arg Leu Glu Phe Ser Arg Asp Phe 
         2035                2040                2045
Gly Ala Thr Trp His Leu Leu Leu Pro Leu Cys Tyr His Ser Ser Ser 
     2050                2055                2060
Leu Val Ser Ser Leu Cys Ser Thr Glu His His Pro Ser Ser Thr Tyr 
 2065                2070                2075                2080
Tyr Ala Gly Thr Thr Gln Gly Trp Arg Arg Glu Val Val His Phe Gly 
                 2085                2090                2095
Lys Leu His Leu Cys Gly Ser Val Arg Phe Arg Trp Tyr Gln Gly Phe 
             2100                2105                2110
Tyr Pro Ala Gly Ser Gln Pro Val Thr Trp Ala Ile Asp Asn Val Tyr 
         2115                2120                2125
Ile Gly Pro Gln Cys Glu Glu Met Cys Tyr Gly His Gly Ser Cys Ile 
     2130                2135                2140
Asn Gly Thr Lys Cys Ile Cys Asp Pro Gly Tyr Ser Gly Pro Thr Cys 
 2145                2150                2155                2160
Lys Ile Ser Thr Lys Asn Pro Asp Phe Leu Lys Asp Asp Phe Glu Gly 
                 2165                2170                2175
Gln Leu Glu Ser Asp Arg Phe Leu Leu Met Ser Gly Gly Lys Pro Ser 
             2180                2185                2190
Arg Lys Cys Gly Ile Leu Ser Ser Gly Asn Asn Leu Phe Phe Asn Glu 
         2195                2200                2205
Asp Gly Leu Arg Met Leu Val Thr Arg Asp Leu Asp Leu Ser His Ala 
     2210                2215                2220
Arg Phe Val Gln Phe Phe Met Arg Leu Gly Cys Gly Lys Gly Val Pro 
 2225                2230                2235                2240
Asp Pro Arg Ser Gln Pro Val Leu Leu Gln Tyr Ser Leu Asn Gly Gly 
                 2245                2250                2255
Leu Ser Trp Ser Leu Leu Gln Glu Phe Leu Phe Ser Asn Ser Ser Asn 
             2260                2265                2270
Val Gly Arg Tyr Ile Ala Leu Glu Met Pro Leu Lys Ala Arg Ser Gly 
         2275                2280                2285
Ser Thr Arg Leu Arg Trp Trp Gln Pro Ser Glu Asn Gly His Phe Tyr 
     2290                2295                2300
Ser Pro Trp Val Ile Asp Gln Ile Leu Ile Gly Gly Asn Ile Ser Gly 
 2305                2310                2315                2320
Asn Thr Val Leu Glu Asp Asp Phe Ser Thr Leu Asp Ser Arg Lys Trp 
                 2325                2330                2335
Leu Leu His Pro Gly Gly Thr Lys Met Pro Val Cys Gly Ser Thr Gly 
             2340                2345                2350
Asp Ala Leu Val Phe Ile Glu Lys Ala Ser Thr Arg Tyr Val Val Thr 
         2355                2360                2365
Thr Asp Ile Ala Val Asn Glu Asp Ser Phe Leu Gln Ile Asp Phe Ala 
     2370                2375                2380
Ala Ser Cys Ser Val Thr Asp Ser Cys Tyr Ala Ile Glu Leu Glu Tyr 
 2385                2390                2395                2400
Ser Val Asp Leu Gly Leu Ser Trp His Pro Leu Val Arg Asp Cys Leu 
                 2405                2410                2415
Pro Thr Asn Val Glu Cys Ser Arg Tyr His Leu Gln Arg Ile Leu Val 
             2420                2425                2430
Ser Asp Thr Phe Asn Lys Trp Thr Arg Ile Thr Leu Pro Leu Pro Ser 
         2435                2440                2445
Tyr Thr Arg Ser Gln Ala Thr Arg Phe Arg Trp His Gln Pro Ala Pro 
     2450                2455                2460
Phe Asp Lys Gln Gln Thr Trp Ala Ile Asp Asn Val Tyr Ile Gly Asp 
 2465                2470                2475                2480
Gly Cys Leu Asp Met Cys Ser Gly His Gly Arg Cys Val Gln Gly Ser 
                 2485                2490                2495
Cys Val Cys Asp Glu Gln Trp Gly Gly Leu Tyr Cys Asp Glu Pro Glu 
             2500                2505                2510
Thr Ser Leu Pro Thr Gln Leu Lys Asp Asn Phe Asn Arg Ala Pro Ser 
         2515                2520                2525
Asn Gln Asn Trp Leu Thr Val Ser Gly Gly Lys Leu Ser Thr Val Cys 
     2530                2535                2540
Gly Ala Val Ala Ser Gly Leu Ala Leu His Phe Ser Gly Gly Cys Ser 
 2545                2550                2555                2560
Arg Leu Leu Val Thr Val Asp Leu Asn Leu Thr Asn Ala Glu Phe Ile 
                 2565                2570                2575
Gln Phe Tyr Phe Met Tyr Gly Cys Leu Ile Thr Pro Ser Asn Arg Asn 
             2580                2585                2590
Gln Gly Val Leu Leu Glu Tyr Ser Val Asn Gly Gly Ile Thr Trp Asn 
         2595                2600                2605
Leu Leu Met Glu Ile Phe Tyr Asp Gln Tyr Ser Lys Pro Gly Phe Val 
     2610                2615                2620
Asn Ile Leu Leu Pro Pro Asp Ala Lys Glu Ile Ala Thr Arg Phe Arg 
 2625                2630                2635                2640
Trp Trp Gln Pro Arg His Asp Gly Leu Asp Gln Asn Asp Trp Ala Ile 
                 2645                2650                2655
Asp Asn Val Leu Ile Ser Gly Ser Ala Asp Gln Arg Thr Val Met Leu 
             2660                2665                2670
Asp Thr Phe Ser Ser Ala Pro Val Pro Gln His Glu Arg Ser Pro Ala 
         2675                2680                2685
Asp Ala Gly Pro Val Gly Arg Ile Ala Phe Glu Met Phe Leu Glu Asp 
     2690                2695                2700
Lys Thr Ser Val Asn Glu Asn Trp Leu Phe His Asp Asp Cys Thr Val 
 2705                2710                2715                2720
Glu Arg Phe Cys Asp Ser Pro Asp Gly Val Met Leu Cys Gly Ser His 
                 2725                2730                2735
Asp Gly Arg Glu Val Tyr Ala Val Thr His Asp Leu Thr Pro Thr Glu 
             2740                2745                2750
Asn Trp Ile Met Gln Phe Lys Ile Ser Val Gly Cys Lys Val Pro Glu 
         2755                2760                2765
Lys Ile Ala Gln Asn Gln Ile His Val Gln Phe Ser Thr Asp Phe Gly 
     2770                2775                2780
Val Ser Trp Ser Tyr Leu Val Pro Gln Cys Leu Pro Ala Asp Pro Lys 
 2785                2790                2795                2800
Cys Ser Gly Ser Val Ser Gln Pro Ser Val Phe Phe Pro Thr Glu Gly 
                 2805                2810                2815
Trp Lys Arg Ile Thr Tyr Pro Leu Pro Glu Ser Leu Thr Gly Asn Pro 
             2820                2825                2830
Val Arg Phe Arg Phe Tyr Gln Lys Tyr Ser Asp Val Gln Trp Ala Ile 
         2835                2840                2845
Asp Asn Phe Tyr Leu Gly Pro Gly Cys Leu Asp Asn Cys Gly Gly His 
     2850                2855                2860
Gly Asp Cys Leu Lys Glu Gln Cys Ile Cys Asp Pro Gly Tyr Ser Gly 
 2865                2870                2875                2880
Pro Asn Cys Tyr Leu Thr His Ser Leu Lys Thr Phe Leu Lys Glu Arg 
                 2885                2890                2895
Phe Asp Ser Glu Glu Ile Lys Pro Asp Leu Trp Met Ser Leu Glu Gly 
             2900                2905                2910
Gly Ser Thr Cys Thr Glu Cys Gly Val Leu Ala Glu Asn Thr Ala Leu 
         2915                2920                2925
Tyr Phe Gly Gly Ser Thr Val Arg Gln Ala Ile Thr Gln Asp Leu Asp 
     2930                2935                2940
Leu Arg Gly Ala Lys Phe Leu Gln Tyr Trp Gly Arg Ile Gly Ser Glu 
 2945                2950                2955                2960
Asn Asn Met Thr Ser Cys His Arg Pro Val Cys Arg Lys Glu Gly Val 
                 2965                2970                2975
Leu Leu Asp Phe Ser Thr Asp Gly Gly Ile Thr Trp Thr Leu Leu His 
             2980                2985                2990
Glu Met Asp Phe Gln Lys Tyr Ile Ser Val Arg His Asp Tyr Ile Leu 
         2995                3000                3005
Leu Pro Glu Gly Ala Leu Thr Asn Thr Thr Arg Leu Arg Trp Trp Gln 
     3010                3015                3020
Pro Phe Val Ile Ser Asn Gly Leu Val Val Ser Gly Val Glu Arg Ala 
 3025                3030                3035                3040
Gln Trp Ala Leu Asp Asn Ile Leu Ile Gly Gly Ala Glu Ile Asn Pro 
                 3045                3050                3055
Ser Gln Leu Val Asp Thr Phe Asp Asp Glu Gly Ser Ser His Glu Glu 
             3060                3065                3070
Asn Trp Ser Phe Tyr Pro Asn Ala Val Arg Thr Ala Gly Phe Cys Gly 
         3075                3080                3085
Asn Pro Ser Phe His Leu Tyr Trp Pro Asn Lys Lys Lys Asp Lys Thr 
     3090                3095                3100
His Asn Ala Leu Ser Ser Arg Glu Leu Ile Ile Gln Pro Gly Tyr Met 
 3105                3110                3115                3120
Met Gln Phe Lys Ile Val Val Gly Cys Glu Ala Thr Ser Cys Gly Asp 
                 3125                3130                3135
Leu His Ser Val Met Leu Glu Tyr Thr Lys Asp Ala Arg Ser Asp Ser 
             3140                3145                3150
Trp Gln Leu Val Gln Thr Gln Cys Leu Pro Ser Ser Ser Asn Ser Ile 
         3155                3160                3165
Gly Cys Ser Pro Phe Gln Phe His Glu Ala Thr Ile Tyr Asn Ala Val 
     3170                3175                3180
Asn Ser Ser Ser Trp Lys Arg Ile Thr Ile Gln Leu Pro Asp His Val 
 3185                3190                3195                3200
Ser Ser Ser Ala Thr Gln Phe Arg Trp Ile Gln Lys Gly Glu Glu Thr 
                 3205                3210                3215
Glu Lys Gln Ser Trp Ala Ile Asp His Val Tyr Ile Gly Glu Ala Cys 
             3220                3225                3230
Pro Lys Leu Cys Ser Gly His Gly Tyr Cys Thr Thr Gly Ala Val Cys 
         3235                3240                3245
Ile Cys Asp Glu Ser Phe Gln Gly Asp Asp Cys Ser Val Phe Ser His 
     3250                3255                3260
Glu Leu Pro Ser Tyr Ile Lys Asp Asn Phe Glu Ser Ala Arg Val Thr 
 3265                3270                3275                3280
Glu Ala Asn Trp Glu Thr Ile Gln Gly Gly Val Ile Gly Ser Gly Cys 
                 3285                3290                3295
Gly Gln Leu Ala Pro Tyr Ala His Gly Asp Ser Leu Tyr Phe Asn Gly 
             3300                3305                3310
Cys Gln Ile Arg Gln Ala Ala Thr Lys Pro Leu Asp Leu Thr Arg Ala 
         3315                3320                3325
Ser Lys Ile Met Phe Val Leu Gln Ile Gly Ser Pro Ala Gln Thr Asp 
     3330                3335                3340
Ser Cys Asn Ser Asp Leu Ser Gly Pro His Thr Val Asp Lys Ala Val 
 3345                3350                3355                3360
Leu Leu Gln Tyr Ser Val Asn Asn Gly Ile Thr Trp His Val Ile Ala 
                 3365                3370                3375
Gln His Gln Pro Lys Asp Phe Thr Gln Ala Gln Arg Val Ser Tyr Asn 
             3380                3385                3390
Val Pro Leu Glu Ala Arg Met Lys Gly Val Leu Leu Arg Trp Trp Gln 
         3395                3400                3405
Pro Arg His Asn Gly Thr Gly His Asp Gln Trp Ala Leu Asp His Val 
     3410                3415                3420
Glu Val Val Leu Val Ser Thr Arg Lys Gln Asn Tyr Met Met Asn Phe 
 3425                3430                3435                3440
Ser Arg Gln His Gly Leu Arg His Phe Tyr Asn Arg Arg Arg Arg Ser 
                 3445                3450                3455
Leu Arg Arg Tyr Pro 
             3460



<210> 6043
<211> 3460
<212> PRT
<213> Homo sapiens
<308> P78509
<400> 6043

Met Glu Arg Ser Gly Trp Ala Arg Gln Thr Phe Leu Leu Ala Leu Leu 
  1               5                  10                  15
Leu Gly Ala Thr Leu Arg Ala Arg Ala Ala Ala Gly Tyr Tyr Pro Arg 
             20                  25                  30
Phe Ser Pro Phe Phe Phe Leu Cys Thr His His Gly Glu Leu Glu Gly 
         35                  40                  45
Asp Gly Glu Gln Gly Glu Val Leu Ile Ser Leu His Ile Ala Gly Asn 
     50                  55                  60
Pro Thr Tyr Tyr Val Pro Gly Gln Glu Tyr His Val Thr Ile Ser Thr 
 65                  70                  75                  80
Ser Thr Phe Phe Asp Gly Leu Leu Val Thr Gly Leu Tyr Thr Ser Thr 
                 85                  90                  95
Ser Val Gln Ala Ser Gln Ser Ile Gly Gly Ser Ser Ala Phe Gly Phe 
             100                105                110
Gly Ile Met Ser Asp His Gln Phe Gly Asn Gln Phe Met Cys Ser Val 
         115                120                125
Val Ala Ser His Val Ser His Leu Pro Thr Thr Asn Leu Ser Phe Ile 
     130                135                140
Trp Ile Ala Pro Pro Ala Gly Thr Gly Cys Val Asn Phe Met Ala Thr 
 145                150                155                160
Ala Thr His Arg Gly Gln Val Ile Phe Lys Asp Ala Leu Ala Gln Gln 
                 165                170                175
Leu Cys Glu Gln Gly Ala Pro Thr Asp Val Thr Val His Pro His Leu 
             180                185                190
Ala Glu Ile His Ser Asp Ser Ile Ile Leu Arg Asp Asp Phe Asp Ser 
         195                200                205
Tyr His Gln Leu Gln Leu Asn Pro Asn Ile Trp Val Glu Cys Asn Asn 
     210                215                220
Cys Glu Thr Gly Glu Gln Cys Gly Ala Ile Met His Gly Asn Ala Val 
 225                230                235                240
Thr Phe Cys Glu Pro Tyr Gly Pro Arg Glu Leu Ile Thr Thr Gly Leu 
                 245                250                255
Asn Thr Thr Thr Ala Ser Val Leu Gln Phe Ser Ile Gly Ser Gly Ser 
             260                265                270
Cys Arg Phe Ser Tyr Ser Asp Pro Ser Ile Ile Val Leu Tyr Ala Lys 
         275                280                285
Asn Asn Ser Ala Asp Trp Ile Gln Leu Glu Lys Ile Arg Ala Pro Ser 
     290                295                300
Asn Val Ser Thr Ile Ile His Ile Leu Tyr Leu Pro Glu Asp Ala Lys 
 305                310                315                320
Gly Glu Asn Val Gln Phe Gln Trp Lys Gln Glu Asn Leu Arg Val Gly 
                 325                330                335
Glu Val Tyr Glu Ala Cys Trp Ala Leu Asp Asn Ile Leu Ile Ile Asn 
             340                345                350
Ser Ala His Arg Gln Val Val Leu Glu Asp Ser Leu Asp Pro Val Asp 
         355                360                365
Thr Gly Asn Trp Leu Phe Phe Pro Gly Ala Thr Val Lys His Ser Cys 
     370                375                380
Gln Ser Asp Gly Asn Ser Ile Tyr Phe His Gly Asn Glu Gly Ser Glu 
 385                390                395                400
Phe Asn Phe Ala Thr Thr Arg Asp Val Asp Leu Ser Thr Glu Asp Ile 
                 405                410                415
Gln Glu Gln Trp Ser Glu Glu Phe Glu Ser Gln Pro Thr Gly Trp Asp 
             420                425                430
Val Leu Gly Ala Val Ile Gly Thr Glu Cys Gly Thr Ile Glu Ser Gly 
         435                440                445
Leu Ser Met Val Phe Leu Lys Asp Gly Glu Arg Lys Leu Cys Thr Pro 
     450                455                460
Ser Met Asp Thr Thr Gly Tyr Gly Asn Leu Arg Phe Tyr Phe Val Met 
 465                470                475                480
Gly Gly Ile Cys Asp Pro Gly Asn Ser His Glu Asn Asp Ile Ile Leu 
                 485                490                495
Tyr Ala Lys Ile Glu Gly Arg Lys Glu His Ile Thr Leu Asp Thr Leu 
             500                505                510
Ser Tyr Ser Ser Tyr Lys Val Pro Ser Leu Val Ser Val Val Ile Asn 
         515                520                525
Pro Glu Leu Gln Thr Pro Ala Thr Lys Phe Cys Leu Arg Gln Lys Asn 
     530                535                540
His Gln Gly His Asn Arg Asn Val Trp Ala Val Asp Phe Phe His Val 
 545                550                555                560
Leu Pro Val Leu Pro Ser Thr Met Ser His Met Ile Gln Phe Ser Ile 
                 565                570                575
Asn Leu Gly Cys Gly Thr His Gln Pro Gly Asn Ser Val Ser Leu Glu 
             580                585                590
Phe Ser Thr Asn His Gly Arg Ser Trp Ser Leu Leu His Thr Glu Cys 
         595                600                605
Leu Pro Glu Ile Cys Ala Gly Pro His Leu Pro His Ser Thr Val Tyr 
     610                615                620
Ser Ser Glu Asn Tyr Ser Gly Trp Asn Arg Ile Thr Ile Pro Leu Pro 
 625                630                635                640
Asn Ala Ala Leu Thr Arg Asn Thr Arg Ile Arg Trp Arg Gln Thr Gly 
                 645                650                655
Pro Ile Leu Gly Asn Met Trp Ala Ile Asp Asn Val Tyr Ile Gly Pro 
             660                665                670
Ser Cys Leu Lys Phe Cys Ser Gly Arg Gly Gln Cys Thr Arg His Gly 
         675                680                685
Cys Lys Cys Asp Pro Gly Phe Ser Gly Pro Ala Cys Glu Met Ala Ser 
     690                695                700
Gln Thr Phe Pro Met Phe Ile Ser Glu Ser Phe Gly Ser Ser Arg Leu 
 705                710                715                720
Ser Ser Tyr His Asn Phe Tyr Ser Ile Arg Gly Ala Glu Val Ser Phe 
                 725                730                735
Gly Cys Gly Val Leu Ala Ser Gly Lys Ala Leu Val Phe Asn Lys Glu 
             740                745                750
Gly Arg Arg Gln Leu Ile Thr Ser Phe Leu Asp Ser Ser Gln Ser Arg 
         755                760                765
Phe Leu Gln Phe Thr Leu Arg Leu Gly Ser Lys Ser Val Leu Ser Thr 
     770                775                780
Cys Arg Ala Pro Asp Gln Pro Gly Glu Gly Val Leu Leu His Tyr Ser 
 785                790                795                800
Tyr Asp Asn Gly Ile Thr Trp Lys Leu Leu Glu His Tyr Ser Tyr Leu 
                 805                810                815
Ser Tyr His Glu Pro Arg Ile Ile Ser Val Glu Leu Pro Gly Asp Ala 
             820                825                830
Lys Gln Phe Gly Ile Gln Phe Arg Trp Trp Gln Pro Tyr His Ser Ser 
         835                840                845
Gln Arg Glu Asp Val Trp Ala Ile Asp Glu Ile Ile Met Thr Ser Val 
     850                855                860
Leu Phe Asn Ser Ile Ser Leu Asp Phe Thr Asn Leu Val Glu Val Thr 
 865                870                875                880
Gln Ser Leu Gly Phe Tyr Leu Gly Asn Val Gln Pro Tyr Cys Gly His 
                 885                890                895
Asp Trp Thr Leu Cys Phe Thr Gly Asp Ser Lys Leu Ala Ser Ser Met 
             900                905                910
Arg Tyr Val Glu Thr Gln Ser Met Gln Ile Gly Ala Ser Tyr Met Ile 
         915                920                925
Gln Phe Ser Leu Val Met Gly Cys Gly Gln Lys Tyr Thr Pro His Met 
     930                935                940
Asp Asn Gln Val Lys Leu Glu Tyr Ser Thr Asn His Gly Leu Thr Trp 
 945                950                955                960
His Leu Val Gln Glu Glu Cys Leu Pro Ser Met Pro Ser Cys Gln Glu 
                 965                970                975
Phe Thr Ser Ala Ser Ile Tyr His Ala Ser Glu Phe Thr Gln Trp Arg 
             980                985                990
Arg Val Ile Val Leu Leu Pro Gln Lys Thr Trp Ser Ser Ala Thr Arg 
         995                1000                1005
Phe Arg Trp Ser Gln Ser Tyr Tyr Thr Ala Gln Asp Glu Trp Ala Leu 
     1010                1015                1020
Asp Ser Ile Tyr Ile Gly Gln Gln Cys Pro Asn Met Cys Ser Gly His 
 1025                1030                1035                1040
Gly Ser Cys Asp His Gly Ile Cys Arg Cys Asp Gln Gly Tyr Gln Gly 
                 1045                1050                1055
Thr Glu Cys His Pro Glu Ala Ala Leu Pro Ser Thr Ile Met Ser Asp 
             1060                1065                1070
Phe Glu Asn Gln Asn Gly Trp Glu Ser Asp Trp Gln Glu Val Ile Gly 
         1075                1080                1085
Gly Glu Ile Val Lys Pro Glu Gln Gly Cys Gly Val Ile Ser Ser Gly 
     1090                1095                1100
Ser Ser Leu Tyr Phe Ser Lys Ala Gly Lys Arg Gln Leu Val Ser Trp 
 1105                1110                1115                1120
Asp Leu Asp Thr Ser Trp Val Asp Phe Val Gln Phe Tyr Ile Gln Ile 
                 1125                1130                1135
Gly Gly Glu Ser Ala Ser Cys Asn Lys Pro Asp Ser Arg Glu Glu Gly 
             1140                1145                1150
Val Leu Leu Gln Tyr Ser Asn Asn Gly Gly Ile Gln Trp His Leu Leu 
         1155                1160                1165
Ala Glu Met Tyr Phe Ser Asp Phe Ser Lys Pro Arg Phe Val Tyr Leu 
     1170                1175                1180
Glu Leu Pro Ala Ala Ala Lys Thr Pro Cys Thr Arg Phe Arg Trp Trp 
 1185                1190                1195                1200
Gln Pro Val Phe Ser Gly Glu Asp Tyr Asp Gln Trp Ala Val Asp Asp 
                 1205                1210                1215
Ile Ile Ile Leu Ser Glu Lys Gln Lys Gln Ile Ile Pro Val Ile Asn 
             1220                1225                1230
Pro Thr Leu Pro Gln Asn Phe Tyr Glu Lys Pro Ala Phe Asp Tyr Pro 
         1235                1240                1245
Met Asn Gln Met Ser Val Trp Leu Met Leu Ala Asn Glu Gly Met Val 
     1250                1255                1260
Lys Asn Glu Thr Phe Cys Ala Ala Thr Pro Ser Ala Met Ile Phe Gly 
 1265                1270                1275                1280
Lys Ser Asp Gly Asp Arg Phe Ala Val Thr Arg Asp Leu Thr Leu Lys 
                 1285                1290                1295
Pro Gly Tyr Val Leu Gln Phe Lys Leu Asn Ile Gly Cys Ala Asn Gln 
             1300                1305                1310
Phe Ser Ser Thr Ala Pro Val Leu Leu Gln Tyr Ser His Asp Ala Gly 
         1315                1320                1325
Met Ser Trp Phe Leu Val Lys Glu Gly Cys Tyr Pro Ala Ser Ala Gly 
     1330                1335                1340
Lys Gly Cys Glu Gly Asn Ser Arg Glu Leu Ser Glu Pro Thr Met Tyr 
 1345                1350                1355                1360
His Thr Gly Asp Phe Glu Glu Trp Thr Arg Ile Thr Ile Val Ile Pro 
                 1365                1370                1375
Arg Ser Leu Ala Ser Ser Lys Thr Arg Phe Arg Trp Ile Gln Glu Ser 
             1380                1385                1390
Ser Ser Gln Lys Asn Val Pro Pro Phe Gly Leu Asp Gly Val Tyr Ile 
         1395                1400                1405
Ser Glu Pro Cys Pro Ser Tyr Cys Ser Gly His Gly Asp Cys Ile Ser 
     1410                1415                1420
Gly Val Cys Phe Cys Asp Leu Gly Tyr Thr Ala Ala Gln Gly Thr Cys 
 1425                1430                1435                1440
Val Ser Asn Val Pro Asn His Asn Glu Met Phe Asp Arg Phe Glu Gly 
                 1445                1450                1455
Lys Leu Ser Pro Leu Trp Tyr Lys Ile Thr Gly Ala Gln Val Gly Thr 
             1460                1465                1470
Gly Cys Gly Thr Leu Asn Asp Gly Lys Ser Leu Tyr Phe Asn Gly Pro 
         1475                1480                1485
Gly Lys Arg Glu Ala Arg Thr Val Pro Leu Asp Thr Arg Asn Ile Arg 
     1490                1495                1500
Leu Val Gln Phe Tyr Ile Gln Ile Gly Ser Lys Thr Ser Gly Ile Thr 
 1505                1510                1515                1520
Cys Ile Lys Pro Arg Thr Arg Asn Glu Gly Leu Ile Val Gln Tyr Ser 
                 1525                1530                1535
Asn Asp Asn Gly Ile Leu Trp His Leu Leu Arg Glu Leu Asp Phe Met 
             1540                1545                1550
Ser Phe Leu Glu Pro Gln Ile Ile Ser Ile Asp Leu Pro Gln Asp Ala 
         1555                1560                1565
Lys Thr Pro Ala Thr Ala Phe Arg Trp Trp Gln Pro Gln His Gly Lys 
     1570                1575                1580
His Ser Ala Gln Trp Ala Leu Asp Asp Val Leu Ile Gly Met Asn Asp 
 1585                1590                1595                1600
Ser Ser Gln Thr Gly Phe Gln Asp Lys Phe Asp Gly Ser Ile Asp Leu 
                 1605                1610                1615
Gln Ala Asn Trp Tyr Arg Ile Gln Gly Gly Gln Val Asp Ile Asp Cys 
             1620                1625                1630
Leu Ser Met Asp Thr Ala Leu Ile Phe Thr Glu Asn Ile Gly Lys Pro 
         1635                1640                1645
Arg Tyr Ala Glu Thr Trp Asp Phe His Val Ser Ala Ser Thr Phe Leu 
     1650                1655                1660
Gln Phe Glu Met Ser Met Gly Cys Ser Lys Pro Phe Ser Asn Ser His 
 1665                1670                1675                1680
Ser Val Gln Leu Gln Tyr Ser Leu Asn Asn Gly Lys Asp Trp His Leu 
                 1685                1690                1695
Val Thr Glu Glu Cys Val Pro Pro Thr Ile Gly Cys Leu His Tyr Thr 
             1700                1705                1710
Glu Ser Ser Ile Tyr Thr Ser Glu Arg Phe Gln Asn Trp Lys Arg Ile 
         1715                1720                1725
Thr Val Tyr Leu Pro Leu Ser Thr Ile Ser Pro Arg Thr Arg Phe Arg 
     1730                1735                1740
Trp Ile Gln Ala Asn Tyr Thr Val Gly Ala Asp Ser Trp Ala Ile Asp 
 1745                1750                1755                1760
Asn Val Val Leu Ala Ser Gly Cys Pro Trp Met Cys Ser Gly Arg Gly 
                 1765                1770                1775
Ile Cys Asp Ala Gly Arg Cys Val Cys Asp Arg Gly Phe Gly Gly Pro 
             1780                1785                1790
Tyr Cys Val Pro Val Val Pro Leu Pro Ser Ile Leu Lys Asp Asp Phe 
         1795                1800                1805
Asn Gly Asn Leu His Pro Asp Leu Trp Pro Glu Val Tyr Gly Ala Glu 
     1810                1815                1820
Arg Gly Asn Leu Asn Gly Glu Thr Ile Lys Ser Gly Thr Ser Leu Ile 
 1825                1830                1835                1840
Phe Lys Gly Glu Gly Leu Arg Met Leu Ile Ser Arg Asp Leu Asp Cys 
                 1845                1850                1855
Thr Asn Thr Met Tyr Val Gln Phe Ser Leu Arg Phe Ile Ala Lys Ser 
             1860                1865                1870
Thr Pro Glu Arg Ser His Ser Ile Leu Leu Gln Phe Ser Ile Ser Gly 
         1875                1880                1885
Gly Ile Thr Trp His Leu Met Asp Glu Phe Tyr Phe Pro Gln Thr Thr 
     1890                1895                1900
Asn Ile Leu Phe Ile Asn Val Pro Leu Pro Tyr Thr Ala Gln Thr Asn 
 1905                1910                1915                1920
Ala Thr Arg Phe Arg Leu Trp Gln Pro Tyr Asn Asn Gly Lys Lys Glu 
                 1925                1930                1935
Glu Ile Trp Ile Val Asp Asp Phe Ile Ile Asp Gly Asn Asn Val Asn 
             1940                1945                1950
Asn Pro Val Met Leu Leu Asp Thr Phe Asp Phe Gly Pro Arg Glu Asp 
         1955                1960                1965
Asn Trp Phe Phe Tyr Pro Gly Gly Asn Ile Gly Leu Tyr Cys Pro Tyr 
     1970                1975                1980
Ser Ser Lys Gly Ala Pro Glu Glu Asp Ser Ala Met Val Phe Val Ser 
 1985                1990                1995                2000
Asn Glu Val Gly Glu His Ser Ile Thr Thr Arg Asp Leu Asn Val Asn 
                 2005                2010                2015
Glu Asn Thr Ile Ile Gln Phe Glu Ile Asn Val Gly Cys Ser Thr Asp 
             2020                2025                2030
Ser Ser Ser Ala Asp Pro Val Arg Leu Glu Phe Ser Arg Asp Phe Gly 
         2035                2040                2045
Ala Thr Trp His Leu Leu Leu Pro Leu Cys Tyr His Ser Ser Ser His 
     2050                2055                2060
Val Ser Ser Leu Cys Ser Thr Glu His His Pro Ser Ser Thr Tyr Tyr 
 2065                2070                2075                2080
Ala Gly Thr Met Gln Gly Trp Arg Arg Glu Val Val His Phe Gly Lys 
                 2085                2090                2095
Leu His Leu Cys Gly Ser Val Arg Phe Arg Trp Tyr Gln Gly Phe Tyr 
             2100                2105                2110
Pro Ala Gly Ser Gln Pro Val Thr Trp Ala Ile Asp Asn Val Tyr Ile 
         2115                2120                2125
Gly Pro Gln Cys Glu Glu Met Cys Asn Gly Gln Gly Ser Cys Ile Asn 
     2130                2135                2140
Gly Thr Lys Cys Ile Cys Asp Pro Gly Tyr Ser Gly Pro Thr Cys Lys 
 2145                2150                2155                2160
Ile Ser Thr Lys Asn Pro Asp Phe Leu Lys Asp Asp Phe Glu Gly Gln 
                 2165                2170                2175
Leu Glu Ser Asp Arg Phe Leu Leu Met Ser Gly Gly Lys Pro Ser Arg 
             2180                2185                2190
Lys Cys Gly Ile Leu Ser Ser Gly Asn Asn Leu Phe Phe Asn Glu Asp 
         2195                2200                2205
Gly Leu Arg Met Leu Met Thr Arg Asp Leu Asp Leu Ser His Ala Arg 
     2210                2215                2220
Phe Val Gln Phe Phe Met Arg Leu Gly Cys Gly Lys Gly Val Pro Asp 
 2225                2230                2235                2240
Pro Arg Ser Gln Pro Val Leu Leu Gln Tyr Ser Leu Asn Gly Gly Leu 
                 2245                2250                2255
Ser Trp Ser Leu Leu Gln Glu Phe Leu Phe Ser Asn Ser Ser Asn Val 
             2260                2265                2270
Gly Arg Tyr Ile Ala Leu Glu Ile Pro Leu Lys Ala Arg Ser Gly Ser 
         2275                2280                2285
Thr Arg Leu Arg Trp Trp Gln Pro Ser Glu Asn Gly His Phe Tyr Ser 
     2290                2295                2300
Pro Trp Val Ile Asp Gln Ile Leu Ile Gly Gly Asn Ile Ser Gly Asn 
 2305                2310                2315                2320
Thr Val Leu Glu Asp Asp Phe Thr Thr Leu Asp Ser Arg Lys Trp Leu 
                 2325                2330                2335
Leu His Pro Gly Gly Thr Lys Met Pro Val Cys Gly Ser Thr Gly Asp 
             2340                2345                2350
Ala Leu Val Phe Ile Glu Lys Ala Ser Thr Arg Tyr Val Val Ser Thr 
         2355                2360                2365
Asp Val Ala Val Asn Glu Asp Ser Phe Leu Gln Ile Asp Phe Ala Ala 
     2370                2375                2380
Ser Cys Ser Val Thr Asp Ser Cys Tyr Ala Ile Glu Leu Glu Tyr Ser 
 2385                2390                2395                2400
Val Asp Leu Gly Leu Ser Trp His Pro Leu Val Arg Asp Cys Leu Pro 
                 2405                2410                2415
Thr Asn Val Glu Cys Ser Arg Tyr His Leu Gln Arg Ile Leu Val Ser 
             2420                2425                2430
Asp Thr Phe Asn Lys Trp Thr Arg Ile Thr Leu Pro Leu Pro Pro Tyr 
         2435                2440                2445
Thr Arg Ser Gln Ala Thr Arg Phe Arg Trp His Gln Pro Ala Pro Phe 
     2450                2455                2460
Asp Lys Gln Gln Thr Trp Ala Ile Asp Asn Val Tyr Ile Gly Asp Gly 
 2465                2470                2475                2480
Cys Ile Asp Met Cys Ser Gly His Gly Arg Cys Ile Gln Gly Asn Cys 
                 2485                2490                2495
Val Cys Asp Glu Gln Trp Gly Gly Leu Tyr Cys Asp Asp Pro Glu Thr 
             2500                2505                2510
Ser Leu Pro Thr Gln Leu Lys Asp Asn Phe Asn Arg Ala Pro Ser Ser 
         2515                2520                2525
Gln Asn Trp Leu Thr Val Asn Gly Gly Lys Leu Ser Thr Val Cys Gly 
     2530                2535                2540
Ala Val Ala Ser Gly Met Ala Leu His Phe Ser Gly Gly Cys Ser Arg 
 2545                2550                2555                2560
Leu Leu Val Thr Val Asp Leu Asn Leu Thr Asn Ala Glu Phe Ile Gln 
                 2565                2570                2575
Phe Tyr Phe Met Tyr Gly Cys Leu Ile Thr Pro Asn Asn Arg Asn Gln 
             2580                2585                2590
Gly Val Leu Leu Glu Tyr Ser Val Asn Gly Gly Ile Thr Trp Asn Leu 
         2595                2600                2605
Leu Met Glu Ile Phe Tyr Asp Gln Tyr Ser Lys Pro Gly Phe Val Asn 
     2610                2615                2620
Ile Leu Leu Pro Pro Asp Ala Lys Glu Ile Ala Thr Arg Phe Arg Trp 
 2625                2630                2635                2640
Trp Gln Pro Arg His Asp Gly Leu Asp Gln Asn Asp Trp Ala Ile Asp 
                 2645                2650                2655
Asn Val Leu Ile Ser Gly Ser Ala Asp Gln Arg Thr Val Met Leu Asp 
             2660                2665                2670
Thr Phe Ser Ser Ala Pro Val Pro Gln His Glu Arg Ser Pro Ala Asp 
         2675                2680                2685
Ala Gly Pro Val Gly Arg Ile Ala Phe Asp Met Phe Met Glu Asp Lys 
     2690                2695                2700
Thr Ser Val Asn Glu His Trp Leu Phe His Asp Asp Cys Thr Val Glu 
 2705                2710                2715                2720
Arg Phe Cys Asp Ser Pro Asp Gly Val Met Leu Cys Gly Ser His Asp 
                 2725                2730                2735
Gly Arg Glu Val Tyr Ala Val Thr His Asp Leu Thr Pro Thr Glu Gly 
             2740                2745                2750
Trp Ile Met Gln Phe Lys Ile Ser Val Gly Cys Lys Val Ser Glu Lys 
         2755                2760                2765
Ile Ala Gln Asn Gln Ile His Val Gln Tyr Ser Thr Asp Phe Gly Val 
     2770                2775                2780
Ser Trp Asn Tyr Leu Val Pro Gln Cys Leu Pro Ala Asp Pro Lys Cys 
 2785                2790                2795                2800
Ser Gly Ser Val Ser Gln Pro Ser Val Phe Phe Pro Thr Lys Gly Trp 
                 2805                2810                2815
Lys Arg Ile Thr Tyr Pro Leu Pro Glu Ser Leu Val Gly Asn Pro Val 
             2820                2825                2830
Arg Phe Arg Phe Tyr Gln Lys Tyr Ser Asp Met Gln Trp Ala Ile Asp 
         2835                2840                2845
Asn Phe Tyr Leu Gly Pro Gly Cys Leu Asp Asn Cys Arg Gly His Gly 
     2850                2855                2860
Asp Cys Leu Arg Glu Gln Cys Ile Cys Asp Pro Gly Tyr Ser Gly Pro 
 2865                2870                2875                2880
Asn Cys Tyr Leu Thr His Thr Leu Lys Thr Phe Leu Lys Glu Arg Phe 
                 2885                2890                2895
Asp Ser Glu Glu Ile Lys Pro Asp Leu Trp Met Ser Leu Glu Gly Gly 
             2900                2905                2910
Ser Thr Cys Thr Glu Cys Gly Ile Leu Ala Glu Asp Thr Ala Leu Tyr 
         2915                2920                2925
Phe Gly Gly Ser Thr Val Arg Gln Ala Val Thr Gln Asp Leu Asp Leu 
     2930                2935                2940
Arg Gly Ala Lys Phe Leu Gln Tyr Trp Gly Arg Ile Gly Ser Glu Asn 
 2945                2950                2955                2960
Asn Met Thr Ser Cys His Arg Pro Ile Cys Arg Lys Glu Gly Val Leu 
                 2965                2970                2975
Leu Asp Tyr Ser Thr Asp Gly Gly Ile Thr Trp Thr Leu Leu His Glu 
             2980                2985                2990
Met Asp Tyr Gln Lys Tyr Ile Ser Val Arg His Asp Tyr Ile Leu Leu 
         2995                3000                3005
Pro Glu Asp Ala Leu Thr Asn Thr Thr Arg Leu Arg Trp Trp Gln Pro 
     3010                3015                3020
Phe Val Ile Ser Asn Gly Ile Val Val Ser Gly Val Glu Arg Ala Gln 
 3025                3030                3035                3040
Trp Ala Leu Asp Asn Ile Leu Ile Gly Gly Ala Glu Ile Asn Pro Ser 
                 3045                3050                3055
Gln Leu Val Asp Thr Phe Asp Asp Glu Gly Thr Ser His Glu Glu Asn 
             3060                3065                3070
Trp Ser Phe Tyr Pro Asn Ala Val Arg Thr Ala Gly Phe Cys Gly Asn 
         3075                3080                3085
Pro Ser Phe His Leu Tyr Trp Pro Asn Lys Lys Lys Asp Lys Thr His 
     3090                3095                3100
Asn Ala Leu Ser Ser Arg Glu Leu Ile Ile Gln Pro Gly Tyr Met Met 
 3105                3110                3115                3120
Gln Phe Lys Ile Val Val Gly Cys Glu Ala Thr Ser Cys Gly Asp Leu 
                 3125                3130                3135
His Ser Val Met Leu Glu Tyr Thr Lys Asp Ala Arg Ser Asp Ser Trp 
             3140                3145                3150
Gln Leu Val Gln Thr Gln Cys Leu Pro Ser Ser Ser Asn Ser Ile Gly 
         3155                3160                3165
Cys Ser Pro Phe Gln Phe His Glu Ala Thr Ile Tyr Asn Ser Val Asn 
     3170                3175                3180
Ser Ser Ser Trp Lys Arg Ile Thr Ile Gln Leu Pro Asp His Val Ser 
 3185                3190                3195                3200
Ser Ser Ala Thr Gln Phe Arg Trp Ile Gln Lys Gly Glu Glu Thr Glu 
                 3205                3210                3215
Lys Gln Ser Trp Ala Ile Asp His Val Tyr Ile Gly Glu Ala Cys Pro 
             3220                3225                3230
Lys Leu Cys Ser Gly His Gly Tyr Cys Thr Thr Gly Ala Ile Cys Ile 
         3235                3240                3245
Cys Asp Glu Ser Phe Gln Gly Asp Asp Cys Ser Val Phe Ser His Asp 
     3250                3255                3260
Leu Pro Ser Tyr Ile Lys Asp Asn Phe Glu Ser Ala Arg Val Thr Glu 
 3265                3270                3275                3280
Ala Asn Trp Glu Thr Ile Gln Gly Gly Val Ile Gly Ser Gly Cys Gly 
                 3285                3290                3295
Gln Leu Ala Pro Tyr Ala His Gly Asp Ser Leu Tyr Phe Asn Gly Cys 
             3300                3305                3310
Gln Ile Arg Gln Ala Ala Thr Lys Pro Leu Asp Leu Thr Arg Ala Ser 
         3315                3320                3325
Lys Ile Met Phe Val Leu Gln Ile Gly Ser Met Ser Gln Thr Asp Ser 
     3330                3335                3340
Cys Asn Ser Asp Leu Ser Gly Pro His Ala Val Asp Lys Ala Val Leu 
 3345                3350                3355                3360
Leu Gln Tyr Ser Val Asn Asn Gly Ile Thr Trp His Val Ile Ala Gln 
                 3365                3370                3375
His Gln Pro Lys Asp Phe Thr Gln Ala Gln Arg Val Ser Tyr Asn Val 
             3380                3385                3390
Pro Leu Glu Ala Arg Met Lys Gly Val Leu Leu Arg Trp Trp Gln Pro 
         3395                3400                3405
Arg His Asn Gly Thr Gly His Asp Gln Trp Ala Leu Asp His Val Glu 
     3410                3415                3420
Val Val Leu Val Ser Thr Arg Lys Gln Asn Tyr Met Met Asn Phe Ser 
 3425                3430                3435                3440
Arg Gln His Gly Leu Arg His Phe Tyr Asn Arg Arg Arg Arg Ser Leu 
                 3445                3450                3455
Arg Arg Tyr Pro 
             3460



<210> 6044
<211> 598
<212> DNA
<213> Rattus norvegicus
<308> AA893532
<400> 6044

gaattagaa  aattttaat  aaatcatca  gtttacatt  gtacatctt  tgggtttgg  60
acccattaa  aggcaaagg  agctatgat  acagattcc  gtgggagag  aagcaggaa  120
caagggttg  cctagttgt  caacaggcg  cccatgaca  tgtgaccca  ttctctgtg  180
tccagggct  tcgaccacg  ctcacagag  ctctctaaa  tctgtgctc  gacctggtg  240
ccacagcgt  ggtgacagg  ctggtaggc  gaagcagat  aacagtcaa  ctgaacatt  300
ctgctcccc  ccagatgcc  atgtgacct  agctcagcc  gtgcagttc  agctagcat  360
gctacagag  ccgaggaag  agctgagcg  cagctgttg  gctacccag  gacagtcac  420
agagagcag  gctgtgaca  aactatgct  tgttcattt  aaaaatggg  tttgtgaaa  480
ggcccctgg  agagtttga  gaaggtaag  aaataagag  ttgtaacat  tgaggtggc  540
ctccacctt  tagaactgt  tgctttaaa  gatttggtg  gggccgggg  tgggctgc  598



<210> 6045
<211> 461
<212> DNA
<213> Rattus norvegicus
<308> AA893569
<400> 6045

ccagggggg  aaaatctta  aggatgaga  gaacagctc  gctaaaaca  agacaaagc  60
ccgttccac  caaacatca  tcctcagaa  tcaagtcac  ctgaacaca  ggaaaacag  120
cacctcaca  cgtggccaa  gctgccagc  aacctggga  cggctcaat  agcaaagtg  180
aggaacctc  cttctgttc  agcccaccc  cagccatga  gaaccccca  caaagggcc  240
gggagggtg  ggaggaacc  tgaagagga  aggaagcat  gggacaggt  cacacacta  300
aatggtctc  tccttgccc  ctctttatt  cagctgagt  gttcagaca  ccgtccttt  360
ttcttgatc  ggctggaca  acctggatc  tgactactg  ccctcatcc  gcttcctct  420
aagcttgag  actatctcc  atctgtaac  tttaagtcc  c  461



<210> 6046
<211> 564
<212> DNA
<213> Rattus norvegicus
<308> AA893596
<400> 6046

ccacattgt  gaaaaacta  gcagaacat  gaacgtttt  gaacaatgg  acaaatagg  60
agacaaagc  aaacaggca  cagggctta  attgtaagt  tatagttaa  actacggat  120
aacatttca  tgcaccaca  ttccaaact  caacgaaga  ggtaggtac  cggggatcc  180
gctgaggag  gatgggtca  tgcagctgt  ctctgtaag  acctattag  aacttcacc  240
acagaagag  agtgaatgt  tcagtacac  cagctccca  ctttaaggt  attgctgtt  300
ttagtaaaa  tataatcct  ctcatcagt  gaaccatta  aatggttca  caatccagc  360
tccttccta  agagcccag  ggcagttta  tactgaagg  agggtttgg  ctgctaagg  420
gggaggcct  catacctga  ccaaagtct  cactcaaga  acatatttg  ccaacatat  480
catcttagt  cttcgacat  tcagtgtta  aaggatgta  aatttaaag  gaaaaaatg  540
gcagttact  tctataaat  tgaa  564



<210> 6047
<211> 307
<212> PRT
<213> Rattus norvegicus
<308> AK016067
<400> 6047

Gly Glu Asp Glu Pro Phe Ile Thr Thr Asn Arg Ile Pro Asn Asn Leu 
  1               5                  10                  15
Leu Arg Asp Ala Val Lys Asn Gly Asp Tyr Ile Ala Val Lys Val Ala 
             20                  25                  30
Leu Asn Ser Asn Glu Glu Tyr Asn Leu Asp Gln Glu Asp Ser Thr Gly 
         35                  40                  45
Met Thr Leu Val Met Leu Ala Ala Ala Gly Gly Gln Asp Asp Leu Leu 
     50                  55                  60
Arg Leu Leu Ile Thr Lys Gly Ala Lys Val Asn Gly Arg Gln Lys Asn 
 65                  70                  75                  80
Gly Thr Thr Ala Leu Ile His Ala Ala Glu Lys Asn Phe Leu Thr Thr 
                 85                  90                  95
Val Ala Ile Leu Leu Glu Ala Gly Ala Phe Val Asn Val Gln Gln Ser 
             100                105                110
Asn Gly Glu Thr Ala Leu Met Lys Ala Cys Lys Arg Gly Asn Ser Asp 
         115                120                125
Ile Val Arg Leu Val Ile Glu Cys Gly Ala Asp Cys Asn Ile Leu Ser 
     130                135                140
Lys His Gln Asn Ser Ala Leu Tyr Phe Ala Lys Gln Cys Asn Asn Val 
 145                150                155                160
Leu Val Tyr Glu Leu Leu Lys Ser His Leu Glu Thr Leu Ser Arg Val 
                 165                170                175
Ala Glu Glu Thr Ile Arg Asp Tyr Phe Glu Ser Arg Leu Ala Leu Leu 
             180                185                190
Glu Pro Val Phe Pro Ile Ala Cys His Arg Leu Cys Glu Gly Pro Asp 
         195                200                205
Phe Ser Thr Asp Phe Asn Tyr Met Pro Pro Gln Asn Met Pro Glu Gly 
     210                215                220
Ser Gly Val Leu Leu Phe Ile Phe His Ala Asn Phe Leu Gly Lys Asp 
 225                230                235                240
Val Ile Ala Arg Leu Cys Gly Pro Cys Ser Val Gln Ala Val Val Leu 
                 245                250                255
Asn Asp Lys Phe Gln Leu Pro Val Phe Leu Asp Ser His Phe Val Tyr 
             260                265                270
Ser Phe Ser Pro Val Ala Gly Pro Asn Lys Leu Phe Ile Arg Leu Thr 
         275                280                285
Glu Ala Pro Phe Ala Lys Val Lys Leu Leu Ile Gly Ala Tyr Arg Val 
     290                295                300
Gln Leu Gln 
 305



<210> 6048
<211> 3234
<212> DNA
<213> Homo sapiens
<308> BC003542
<400> 6048

gctgctagg  tggagcagg  tgcggaggg  gcaagggtg  ccgcagtcc  tgtgtcagc  60
gccgacagc  ctgaggagt  ggccgaagt  gaagaagga  ttggagtag  gggcgaaga  120
aatgacgca  ccgcgagag  agcggaggc  tttggcgac  gtgaggagg  cggagagga  180
gtgttcgag  tggagaaga  cctggacat  aagaccgag  ggggtaaag  tctttacaa  240
gttcgctgg  aaggctata  atcggatga  gatacctgg  agcccgaga  tcacctgga  300
gactgtaaa  aagtgcttc  tgaatttag  aagaaaatt  cagagaaca  agccaaagc  360
gtcaggaag  atattcaga  actatcctt  aataacgac  tatttgagg  gaactctga  420
agcgatcag  aaagtgaga  aaaagaaga  acttcccca  agaagaaaa  gaaaaaatt  480
aggcagaga  aagagaaaa  cccagatga  ctgaaaaag  aaaaagcaa  ggccgggaa  540
ctaaaagac  agtccaaac  agacctgga  agctccttg  aaagtttag  ttttgattt  600
aggacaaag  aaagaattt  tgaagccaa  gaagaacta  aggagtcca  aaagcccaa  660
aaagatgaa  taaaagaaa  aaaagaatt  aagaaagtt  aaaagggtg  aataagaga  720
ttaaagacg  aaacaagag  agatcccaa  gaaaataga  aaacaaaaa  agaaaaatt  780
gtcgaatcc  aggtggaat  tgaatcaag  gtacttaat  attctccct  tccagagga  840
gacagtgaa  ggctacatt  cgacagcag  gaagagaaa  aaaacacta  aagtgcaag  900
gagagagca  ggcaggaca  ggggctgga  catggcttt  agaagcccc  agacagtgc  960
atgagtgct  aggaggata  cgatgtcag  ggcaggagg  aaaagaaga  cccgagaaa  1020
gctgaggac  ctagagaga  caggaagct  gagaacaag  acgctttct  agagaagaa  1080
actgtgcct  aaaagcaga  gaatcaaga  agaagcaaa  gtgctgcag  gttagagaa  1140
ctgatgcct  tatctgccc  aacgccaaa  ggccggagg  tgagcgggg  agagagagg  1200
ctctggtcc  cggactcag  cgaggagga  aaagaaacc  aaagaaatg  atccaaaga  1260
aaatatcag  aaaggcatg  ttctgacaa  gaagaaaaa  gcagaaaag  gccaaaagg  1320
ttaaagaca  ttaaggaaa  cagaaatgc  tttgattta  ttaaattaa  tccagaaga  1380
aaaaatgat  tttctgaga  taatcggaa  agggaagaa  taccactgg  ttttaaaac  1440
atagacgat  acaaaacca  ggaaaacaa  cagtcactt  aagaaagga  aaacaccag  1500
gacgaaacg  atacttggg  atacattgc  gcagaaggt  atcaggagg  tttagacag  1560
gtgtgccaa  cagatgaga  ttcagatgg  aggcagcag  ttctgagtt  gggcatgga  1620
ctgcagttg  aatggatga  gttggaaga  ttccaaaag  accttgatg  gaaagatga  1680
aattttgct  caacagatg  aattccaag  aatgtgtta  gggatgctg  gaaaaatgg  1740
gattatatt  ctgtaaaag  tgcacttaa  tcaaatgaa  aatataacc  ggaccaaga  1800
gattccagt  gaatgacac  ggtgatgct  gccgccgcc  gagggcagg  cgacctcct  1860
cgactcctc  tcacaaaag  cgcgaaagt  aacggtcgg  agaagaacg  gaccaccgc  1920
ctcattcat  ctgcagaga  gaacttttt  acaacagtg  ctattcttt  ggaagcagg  1980
gcttttgta  atgtccagc  aagcaatgg  gagactgca  tgatgaagg  ctgtaaaag  2040
ggaaattca  acatcgtac  actcgtaat  gaatgtgga  ctgactgca  tattttgtc  2100
aagcaccag  atagtgccc  gcactttgc  aagcagtct  acaatgtgc  tgtgtacga  2160
ttgctgaag  accatttag  gacactttc  agagtagca  aagagacaa  aaaggatta  2220
tttgaagct  gccttgctc  gctagaacc  gtttttcca  tcgcatgtc  tcgactctg  2280
gagggtcca  atttttcaa  agatttcaa  tacaaaccc  cacagaaca  accagaagg  2340
tctggcatc  tgctgttta  cttccatgc  aactttttg  gtaaagaag  tattgctcg  2400
ctctgtgga  cgtgtagtg  acaagctgt  gttctgaat  ataaatttc  gcttcctgt  2460
tttctggac  gtcattttg  ttactcatt  agccctgtt  caggtccca  taaactctt  2520
ataaggttg  cagaagcac  ctctgccaa  gttaagttg  taataggtg  atacagagt  2580
cagctgcag  gaccaaaca  aagggactg  gcggagttc  cttcagacc  attcctata  2640
tctctttga  agcagtttg  aattcttct  gcacatcta  gtaaagttt  gtctgtaaa  2700
ctcttgcag  taagcctgt  gtctgttgt  gtctgtaag  tgcgacata  ctgtgtctg  2760
gccagtatg  cggaatctc  gtgcagtgt  cagactgcg  atttcagtt  ttccacaat  2820
tggatagta  atatgagga  tatttaaga  aattaaaga  ttcactttc  tttttctgg  2880
gacggagtt  cgctcttgt  gcccaggct  gagtgcaat  gtgcgatct  ggctcgctg  2940
aagctctgc  tcctgggtt  aagtgattc  cctgcctca  cctcctgag  agctgggat  3000
acagacacc  gccatggca  ccagctaat  ttgtatttt  agtagagat  gggtttatc  3060
atgttggtc  ggctggtct  gaactcctg  cctcaggtg  tccgcccgc  tcggcctcc  3120
aaagtgctt  gattacagg  atgagccac  gcacccagc  agagttatt  tcttaactt  3180
aaattttct  ctagccctg  tgaacttct  tgcttaaaa  aaaaaaaaa  aaaa  3234



<210> 6049
<211> 863
<212> PRT
<213> Homo sapiens
<308> AAH03542
<400> 6049

Ala Ala Arg Met Glu Gln Val Ala Glu Gly Ala Arg Val Thr Ala Val 
  1               5                  10                  15
Pro Val Ser Ala Ala Asp Ser Thr Glu Glu Leu Ala Glu Val Glu Glu 
             20                  25                  30
Gly Val Gly Val Val Gly Glu Asp Asn Asp Ala Ala Ala Arg Gly Ala 
         35                  40                  45
Glu Ala Phe Gly Asp Ser Glu Glu Asp Gly Glu Asp Val Phe Glu Val 
     50                  55                  60
Glu Lys Ile Leu Asp Met Lys Thr Glu Gly Gly Lys Val Leu Tyr Lys 
 65                  70                  75                  80
Val Arg Trp Lys Gly Tyr Thr Ser Asp Asp Asp Thr Trp Glu Pro Glu 
                 85                  90                  95
Ile His Leu Glu Asp Cys Lys Glu Val Leu Leu Glu Phe Arg Lys Lys 
             100                105                110
Ile Ala Glu Asn Lys Ala Lys Ala Val Arg Lys Asp Ile Gln Arg Leu 
         115                120                125
Ser Leu Asn Asn Asp Ile Phe Glu Ala Asn Ser Asp Ser Asp Gln Gln 
     130                135                140
Ser Glu Thr Lys Glu Asp Thr Ser Pro Lys Lys Lys Lys Lys Lys Leu 
 145                150                155                160
Arg Gln Arg Glu Glu Lys Ser Pro Asp Asp Leu Lys Lys Lys Lys Ala 
                 165                170                175
Lys Ala Gly Lys Leu Lys Asp Lys Ser Lys Pro Asp Leu Glu Ser Ser 
             180                185                190
Leu Glu Ser Leu Val Phe Asp Leu Arg Thr Lys Lys Arg Ile Ser Glu 
         195                200                205
Ala Lys Glu Glu Leu Lys Glu Ser Lys Lys Pro Lys Lys Asp Glu Val 
     210                215                220
Lys Glu Thr Lys Glu Leu Lys Lys Val Lys Lys Gly Glu Ile Arg Asp 
 225                230                235                240
Leu Lys Thr Lys Thr Arg Glu Asp Pro Lys Glu Asn Arg Lys Thr Lys 
                 245                250                255
Lys Glu Lys Phe Val Glu Ser Gln Val Glu Ser Glu Ser Ser Val Leu 
             260                265                270
Asn Asp Ser Pro Phe Pro Glu Asp Asp Ser Glu Gly Leu His Ser Asp 
         275                280                285
Ser Arg Glu Glu Lys Gln Asn Thr Lys Ser Ala Arg Glu Arg Ala Gly 
     290                295                300
Gln Asp Met Gly Leu Glu His Gly Phe Glu Lys Pro Leu Asp Ser Ala 
 305                310                315                320
Met Ser Ala Glu Glu Asp Thr Asp Val Arg Gly Arg Arg Lys Lys Lys 
                 325                330                335
Thr Pro Arg Lys Ala Glu Asp Thr Arg Glu Asn Arg Lys Leu Glu Asn 
             340                345                350
Lys Asn Ala Phe Leu Glu Lys Lys Thr Val Pro Lys Lys Gln Arg Asn 
         355                360                365
Gln Asp Arg Ser Lys Ser Ala Ala Glu Leu Glu Lys Leu Met Pro Val 
     370                375                380
Ser Ala Gln Thr Pro Lys Gly Arg Arg Leu Ser Gly Glu Glu Arg Gly 
 385                390                395                400
Leu Trp Ser Thr Asp Ser Ala Glu Glu Asp Lys Glu Thr Lys Arg Asn 
                 405                410                415
Glu Ser Lys Glu Lys Tyr Gln Lys Arg His Asp Ser Asp Lys Glu Glu 
             420                425                430
Lys Gly Arg Lys Glu Pro Lys Gly Leu Lys Thr Leu Lys Glu Ile Arg 
         435                440                445
Asn Ala Phe Asp Leu Phe Lys Leu Thr Pro Glu Glu Lys Asn Asp Val 
     450                455                460
Ser Glu Asn Asn Arg Lys Arg Glu Glu Ile Pro Leu Asp Phe Lys Thr 
 465                470                475                480
Ile Asp Asp His Lys Thr Lys Glu Asn Lys Gln Ser Leu Lys Glu Arg 
                 485                490                495
Arg Asn Thr Arg Asp Glu Thr Asp Thr Trp Ala Tyr Ile Ala Ala Glu 
             500                505                510
Gly Asp Gln Glu Val Leu Asp Ser Val Cys Gln Ala Asp Glu Asn Ser 
         515                520                525
Asp Gly Arg Gln Gln Ile Leu Ser Leu Gly Met Asp Leu Gln Leu Glu 
     530                535                540
Trp Met Lys Leu Glu Asp Phe Gln Lys His Leu Asp Gly Lys Asp Glu 
 545                550                555                560
Asn Phe Ala Ala Thr Asp Ala Ile Pro Ser Asn Val Leu Arg Asp Ala 
                 565                570                575
Val Lys Asn Gly Asp Tyr Ile Thr Val Lys Val Ala Leu Asn Ser Asn 
             580                585                590
Glu Glu Tyr Asn Leu Asp Gln Glu Asp Ser Ser Gly Met Thr Leu Val 
         595                600                605
Met Leu Ala Ala Ala Gly Gly Gln Asp Asp Leu Leu Arg Leu Leu Ile 
     610                615                620
Thr Lys Gly Ala Lys Val Asn Gly Arg Gln Lys Asn Gly Thr Thr Ala 
 625                630                635                640
Leu Ile His Ala Ala Glu Lys Asn Phe Leu Thr Thr Val Ala Ile Leu 
                 645                650                655
Leu Glu Ala Gly Ala Phe Val Asn Val Gln Gln Ser Asn Gly Glu Thr 
             660                665                670
Ala Leu Met Lys Ala Cys Lys Arg Gly Asn Ser Asp Ile Val Arg Leu 
         675                680                685
Val Ile Glu Cys Gly Ala Asp Cys Asn Ile Leu Ser Lys His Gln Asn 
     690                695                700
Ser Ala Leu His Phe Ala Lys Gln Ser Asn Asn Val Leu Val Tyr Asp 
 705                710                715                720
Leu Leu Lys Asn His Leu Glu Thr Leu Ser Arg Val Ala Glu Glu Thr 
                 725                730                735
Ile Lys Asp Tyr Phe Glu Ala Arg Leu Ala Leu Leu Glu Pro Val Phe 
             740                745                750
Pro Ile Ala Cys His Arg Leu Cys Glu Gly Pro Asp Phe Ser Thr Asp 
         755                760                765
Phe Asn Tyr Lys Pro Pro Gln Asn Ile Pro Glu Gly Ser Gly Ile Leu 
     770                775                780
Leu Phe Ile Phe His Ala Asn Phe Leu Gly Lys Glu Val Ile Ala Arg 
 785                790                795                800
Leu Cys Gly Pro Cys Ser Val Gln Ala Val Val Leu Asn Asp Lys Phe 
                 805                810                815
Gln Leu Pro Val Phe Leu Asp Ser His Phe Val Tyr Ser Phe Ser Pro 
             820                825                830
Val Ala Gly Pro Asn Lys Leu Phe Ile Arg Leu Thr Glu Ala Pro Ser 
         835                840                845
Ala Lys Val Lys Leu Leu Ile Gly Ala Tyr Arg Val Gln Leu Gln 
     850                855                860



<210> 6050
<211> 564
<212> DNA
<213> Rattus norvegicus
<308> AA893596
<400> 6050

ccacattgt  gaaaaacta  gcagaacat  gaacgtttt  gaacaatgg  acaaatagg  60
agacaaagc  aaacaggca  cagggctta  attgtaagt  tatagttaa  actacggat  120
aacatttca  tgcaccaca  ttccaaact  caacgaaga  ggtaggtac  cggggatcc  180
gctgaggag  gatgggtca  tgcagctgt  ctctgtaag  acctattag  aacttcacc  240
acagaagag  agtgaatgt  tcagtacac  cagctccca  ctttaaggt  attgctgtt  300
ttagtaaaa  tataatcct  ctcatcagt  gaaccatta  aatggttca  caatccagc  360
tccttccta  agagcccag  ggcagttta  tactgaagg  agggtttgg  ctgctaagg  420
gggaggcct  catacctga  ccaaagtct  cactcaaga  acatatttg  ccaacatat  480
catcttagt  cttcgacat  tcagtgtta  aaggatgta  aatttaaag  gaaaaaatg  540
gcagttact  tctataaat  tgaa  564



<210> 6051
<211> 307
<212> PRT
<213> Rattus norvegicus
<308> AK016067
<400> 6051

Gly Glu Asp Glu Pro Phe Ile Thr Thr Asn Arg Ile Pro Asn Asn Leu 
  1               5                  10                  15
Leu Arg Asp Ala Val Lys Asn Gly Asp Tyr Ile Ala Val Lys Val Ala 
             20                  25                  30
Leu Asn Ser Asn Glu Glu Tyr Asn Leu Asp Gln Glu Asp Ser Thr Gly 
         35                  40                  45
Met Thr Leu Val Met Leu Ala Ala Ala Gly Gly Gln Asp Asp Leu Leu 
     50                  55                  60
Arg Leu Leu Ile Thr Lys Gly Ala Lys Val Asn Gly Arg Gln Lys Asn 
 65                  70                  75                  80
Gly Thr Thr Ala Leu Ile His Ala Ala Glu Lys Asn Phe Leu Thr Thr 
                 85                  90                  95
Val Ala Ile Leu Leu Glu Ala Gly Ala Phe Val Asn Val Gln Gln Ser 
             100                105                110
Asn Gly Glu Thr Ala Leu Met Lys Ala Cys Lys Arg Gly Asn Ser Asp 
         115                120                125
Ile Val Arg Leu Val Ile Glu Cys Gly Ala Asp Cys Asn Ile Leu Ser 
     130                135                140
Lys His Gln Asn Ser Ala Leu Tyr Phe Ala Lys Gln Cys Asn Asn Val 
 145                150                155                160
Leu Val Tyr Glu Leu Leu Lys Ser His Leu Glu Thr Leu Ser Arg Val 
                 165                170                175
Ala Glu Glu Thr Ile Arg Asp Tyr Phe Glu Ser Arg Leu Ala Leu Leu 
             180                185                190
Glu Pro Val Phe Pro Ile Ala Cys His Arg Leu Cys Glu Gly Pro Asp 
         195                200                205
Phe Ser Thr Asp Phe Asn Tyr Met Pro Pro Gln Asn Met Pro Glu Gly 
     210                215                220
Ser Gly Val Leu Leu Phe Ile Phe His Ala Asn Phe Leu Gly Lys Asp 
 225                230                235                240
Val Ile Ala Arg Leu Cys Gly Pro Cys Ser Val Gln Ala Val Val Leu 
                 245                250                255
Asn Asp Lys Phe Gln Leu Pro Val Phe Leu Asp Ser His Phe Val Tyr 
             260                265                270
Ser Phe Ser Pro Val Ala Gly Pro Asn Lys Leu Phe Ile Arg Leu Thr 
         275                280                285
Glu Ala Pro Phe Ala Lys Val Lys Leu Leu Ile Gly Ala Tyr Arg Val 
     290                295                300
Gln Leu Gln 
 305



<210> 6052
<211> 3234
<212> DNA
<213> Homo sapiens
<308> BC003542
<400> 6052

gctgctagg  tggagcagg  tgcggaggg  gcaagggtg  ccgcagtcc  tgtgtcagc  60
gccgacagc  ctgaggagt  ggccgaagt  gaagaagga  ttggagtag  gggcgaaga  120
aatgacgca  ccgcgagag  agcggaggc  tttggcgac  gtgaggagg  cggagagga  180
gtgttcgag  tggagaaga  cctggacat  aagaccgag  ggggtaaag  tctttacaa  240
gttcgctgg  aaggctata  atcggatga  gatacctgg  agcccgaga  tcacctgga  300
gactgtaaa  aagtgcttc  tgaatttag  aagaaaatt  cagagaaca  agccaaagc  360
gtcaggaag  atattcaga  actatcctt  aataacgac  tatttgagg  gaactctga  420
agcgatcag  aaagtgaga  aaaagaaga  acttcccca  agaagaaaa  gaaaaaatt  480
aggcagaga  aagagaaaa  cccagatga  ctgaaaaag  aaaaagcaa  ggccgggaa  540
ctaaaagac  agtccaaac  agacctgga  agctccttg  aaagtttag  ttttgattt  600
aggacaaag  aaagaattt  tgaagccaa  gaagaacta  aggagtcca  aaagcccaa  660
aaagatgaa  taaaagaaa  aaaagaatt  aagaaagtt  aaaagggtg  aataagaga  720
ttaaagacg  aaacaagag  agatcccaa  gaaaataga  aaacaaaaa  agaaaaatt  780
gtcgaatcc  aggtggaat  tgaatcaag  gtacttaat  attctccct  tccagagga  840
gacagtgaa  ggctacatt  cgacagcag  gaagagaaa  aaaacacta  aagtgcaag  900
gagagagca  ggcaggaca  ggggctgga  catggcttt  agaagcccc  agacagtgc  960
atgagtgct  aggaggata  cgatgtcag  ggcaggagg  aaaagaaga  cccgagaaa  1020
gctgaggac  ctagagaga  caggaagct  gagaacaag  acgctttct  agagaagaa  1080
actgtgcct  aaaagcaga  gaatcaaga  agaagcaaa  gtgctgcag  gttagagaa  1140
ctgatgcct  tatctgccc  aacgccaaa  ggccggagg  tgagcgggg  agagagagg  1200
ctctggtcc  cggactcag  cgaggagga  aaagaaacc  aaagaaatg  atccaaaga  1260
aaatatcag  aaaggcatg  ttctgacaa  gaagaaaaa  gcagaaaag  gccaaaagg  1320
ttaaagaca  ttaaggaaa  cagaaatgc  tttgattta  ttaaattaa  tccagaaga  1380
aaaaatgat  tttctgaga  taatcggaa  agggaagaa  taccactgg  ttttaaaac  1440
atagacgat  acaaaacca  ggaaaacaa  cagtcactt  aagaaagga  aaacaccag  1500
gacgaaacg  atacttggg  atacattgc  gcagaaggt  atcaggagg  tttagacag  1560
gtgtgccaa  cagatgaga  ttcagatgg  aggcagcag  ttctgagtt  gggcatgga  1620
ctgcagttg  aatggatga  gttggaaga  ttccaaaag  accttgatg  gaaagatga  1680
aattttgct  caacagatg  aattccaag  aatgtgtta  gggatgctg  gaaaaatgg  1740
gattatatt  ctgtaaaag  tgcacttaa  tcaaatgaa  aatataacc  ggaccaaga  1800
gattccagt  gaatgacac  ggtgatgct  gccgccgcc  gagggcagg  cgacctcct  1860
cgactcctc  tcacaaaag  cgcgaaagt  aacggtcgg  agaagaacg  gaccaccgc  1920
ctcattcat  ctgcagaga  gaacttttt  acaacagtg  ctattcttt  ggaagcagg  1980
gcttttgta  atgtccagc  aagcaatgg  gagactgca  tgatgaagg  ctgtaaaag  2040
ggaaattca  acatcgtac  actcgtaat  gaatgtgga  ctgactgca  tattttgtc  2100
aagcaccag  atagtgccc  gcactttgc  aagcagtct  acaatgtgc  tgtgtacga  2160
ttgctgaag  accatttag  gacactttc  agagtagca  aagagacaa  aaaggatta  2220
tttgaagct  gccttgctc  gctagaacc  gtttttcca  tcgcatgtc  tcgactctg  2280
gagggtcca  atttttcaa  agatttcaa  tacaaaccc  cacagaaca  accagaagg  2340
tctggcatc  tgctgttta  cttccatgc  aactttttg  gtaaagaag  tattgctcg  2400
ctctgtgga  cgtgtagtg  acaagctgt  gttctgaat  ataaatttc  gcttcctgt  2460
tttctggac  gtcattttg  ttactcatt  agccctgtt  caggtccca  taaactctt  2520
ataaggttg  cagaagcac  ctctgccaa  gttaagttg  taataggtg  atacagagt  2580
cagctgcag  gaccaaaca  aagggactg  gcggagttc  cttcagacc  attcctata  2640
tctctttga  agcagtttg  aattcttct  gcacatcta  gtaaagttt  gtctgtaaa  2700
ctcttgcag  taagcctgt  gtctgttgt  gtctgtaag  tgcgacata  ctgtgtctg  2760
gccagtatg  cggaatctc  gtgcagtgt  cagactgcg  atttcagtt  ttccacaat  2820
tggatagta  atatgagga  tatttaaga  aattaaaga  ttcactttc  tttttctgg  2880
gacggagtt  cgctcttgt  gcccaggct  gagtgcaat  gtgcgatct  ggctcgctg  2940
aagctctgc  tcctgggtt  aagtgattc  cctgcctca  cctcctgag  agctgggat  3000
acagacacc  gccatggca  ccagctaat  ttgtatttt  agtagagat  gggtttatc  3060
atgttggtc  ggctggtct  gaactcctg  cctcaggtg  tccgcccgc  tcggcctcc  3120
aaagtgctt  gattacagg  atgagccac  gcacccagc  agagttatt  tcttaactt  3180
aaattttct  ctagccctg  tgaacttct  tgcttaaaa  aaaaaaaaa  aaaa  3234



<210> 6053
<211> 863
<212> PRT
<213> Homo sapiens
<308> AAH03542
<400> 6053

Ala Ala Arg Met Glu Gln Val Ala Glu Gly Ala Arg Val Thr Ala Val 
  1               5                  10                  15
Pro Val Ser Ala Ala Asp Ser Thr Glu Glu Leu Ala Glu Val Glu Glu 
             20                  25                  30
Gly Val Gly Val Val Gly Glu Asp Asn Asp Ala Ala Ala Arg Gly Ala 
         35                  40                  45
Glu Ala Phe Gly Asp Ser Glu Glu Asp Gly Glu Asp Val Phe Glu Val 
     50                  55                  60
Glu Lys Ile Leu Asp Met Lys Thr Glu Gly Gly Lys Val Leu Tyr Lys 
 65                  70                  75                  80
Val Arg Trp Lys Gly Tyr Thr Ser Asp Asp Asp Thr Trp Glu Pro Glu 
                 85                  90                  95
Ile His Leu Glu Asp Cys Lys Glu Val Leu Leu Glu Phe Arg Lys Lys 
             100                105                110
Ile Ala Glu Asn Lys Ala Lys Ala Val Arg Lys Asp Ile Gln Arg Leu 
         115                120                125
Ser Leu Asn Asn Asp Ile Phe Glu Ala Asn Ser Asp Ser Asp Gln Gln 
     130                135                140
Ser Glu Thr Lys Glu Asp Thr Ser Pro Lys Lys Lys Lys Lys Lys Leu 
 145                150                155                160
Arg Gln Arg Glu Glu Lys Ser Pro Asp Asp Leu Lys Lys Lys Lys Ala 
                 165                170                175
Lys Ala Gly Lys Leu Lys Asp Lys Ser Lys Pro Asp Leu Glu Ser Ser 
             180                185                190
Leu Glu Ser Leu Val Phe Asp Leu Arg Thr Lys Lys Arg Ile Ser Glu 
         195                200                205
Ala Lys Glu Glu Leu Lys Glu Ser Lys Lys Pro Lys Lys Asp Glu Val 
     210                215                220
Lys Glu Thr Lys Glu Leu Lys Lys Val Lys Lys Gly Glu Ile Arg Asp 
 225                230                235                240
Leu Lys Thr Lys Thr Arg Glu Asp Pro Lys Glu Asn Arg Lys Thr Lys 
                 245                250                255
Lys Glu Lys Phe Val Glu Ser Gln Val Glu Ser Glu Ser Ser Val Leu 
             260                265                270
Asn Asp Ser Pro Phe Pro Glu Asp Asp Ser Glu Gly Leu His Ser Asp 
         275                280                285
Ser Arg Glu Glu Lys Gln Asn Thr Lys Ser Ala Arg Glu Arg Ala Gly 
     290                295                300
Gln Asp Met Gly Leu Glu His Gly Phe Glu Lys Pro Leu Asp Ser Ala 
 305                310                315                320
Met Ser Ala Glu Glu Asp Thr Asp Val Arg Gly Arg Arg Lys Lys Lys 
                 325                330                335
Thr Pro Arg Lys Ala Glu Asp Thr Arg Glu Asn Arg Lys Leu Glu Asn 
             340                345                350
Lys Asn Ala Phe Leu Glu Lys Lys Thr Val Pro Lys Lys Gln Arg Asn 
         355                360                365
Gln Asp Arg Ser Lys Ser Ala Ala Glu Leu Glu Lys Leu Met Pro Val 
     370                375                380
Ser Ala Gln Thr Pro Lys Gly Arg Arg Leu Ser Gly Glu Glu Arg Gly 
 385                390                395                400
Leu Trp Ser Thr Asp Ser Ala Glu Glu Asp Lys Glu Thr Lys Arg Asn 
                 405                410                415
Glu Ser Lys Glu Lys Tyr Gln Lys Arg His Asp Ser Asp Lys Glu Glu 
             420                425                430
Lys Gly Arg Lys Glu Pro Lys Gly Leu Lys Thr Leu Lys Glu Ile Arg 
         435                440                445
Asn Ala Phe Asp Leu Phe Lys Leu Thr Pro Glu Glu Lys Asn Asp Val 
     450                455                460
Ser Glu Asn Asn Arg Lys Arg Glu Glu Ile Pro Leu Asp Phe Lys Thr 
 465                470                475                480
Ile Asp Asp His Lys Thr Lys Glu Asn Lys Gln Ser Leu Lys Glu Arg 
                 485                490                495
Arg Asn Thr Arg Asp Glu Thr Asp Thr Trp Ala Tyr Ile Ala Ala Glu 
             500                505                510
Gly Asp Gln Glu Val Leu Asp Ser Val Cys Gln Ala Asp Glu Asn Ser 
         515                520                525
Asp Gly Arg Gln Gln Ile Leu Ser Leu Gly Met Asp Leu Gln Leu Glu 
     530                535                540
Trp Met Lys Leu Glu Asp Phe Gln Lys His Leu Asp Gly Lys Asp Glu 
 545                550                555                560
Asn Phe Ala Ala Thr Asp Ala Ile Pro Ser Asn Val Leu Arg Asp Ala 
                 565                570                575
Val Lys Asn Gly Asp Tyr Ile Thr Val Lys Val Ala Leu Asn Ser Asn 
             580                585                590
Glu Glu Tyr Asn Leu Asp Gln Glu Asp Ser Ser Gly Met Thr Leu Val 
         595                600                605
Met Leu Ala Ala Ala Gly Gly Gln Asp Asp Leu Leu Arg Leu Leu Ile 
     610                615                620
Thr Lys Gly Ala Lys Val Asn Gly Arg Gln Lys Asn Gly Thr Thr Ala 
 625                630                635                640
Leu Ile His Ala Ala Glu Lys Asn Phe Leu Thr Thr Val Ala Ile Leu 
                 645                650                655
Leu Glu Ala Gly Ala Phe Val Asn Val Gln Gln Ser Asn Gly Glu Thr 
             660                665                670
Ala Leu Met Lys Ala Cys Lys Arg Gly Asn Ser Asp Ile Val Arg Leu 
         675                680                685
Val Ile Glu Cys Gly Ala Asp Cys Asn Ile Leu Ser Lys His Gln Asn 
     690                695                700
Ser Ala Leu His Phe Ala Lys Gln Ser Asn Asn Val Leu Val Tyr Asp 
 705                710                715                720
Leu Leu Lys Asn His Leu Glu Thr Leu Ser Arg Val Ala Glu Glu Thr 
                 725                730                735
Ile Lys Asp Tyr Phe Glu Ala Arg Leu Ala Leu Leu Glu Pro Val Phe 
             740                745                750
Pro Ile Ala Cys His Arg Leu Cys Glu Gly Pro Asp Phe Ser Thr Asp 
         755                760                765
Phe Asn Tyr Lys Pro Pro Gln Asn Ile Pro Glu Gly Ser Gly Ile Leu 
     770                775                780
Leu Phe Ile Phe His Ala Asn Phe Leu Gly Lys Glu Val Ile Ala Arg 
 785                790                795                800
Leu Cys Gly Pro Cys Ser Val Gln Ala Val Val Leu Asn Asp Lys Phe 
                 805                810                815
Gln Leu Pro Val Phe Leu Asp Ser His Phe Val Tyr Ser Phe Ser Pro 
             820                825                830
Val Ala Gly Pro Asn Lys Leu Phe Ile Arg Leu Thr Glu Ala Pro Ser 
         835                840                845
Ala Lys Val Lys Leu Leu Ile Gly Ala Tyr Arg Val Gln Leu Gln 
     850                855                860



<210> 6054
<211> 511
<212> DNA
<213> Rattus norvegicus
<308> AA893603
<400> 6054

ggagaccac  atttatttt  ggttaatgc  aaccaggaa  actactccc  tagtacagt  60
tgacacagg  tcctcagga  gacaacaat  gaaagcaag  gcatggcag  tttcctgtt  120
cagacctga  gtttgggag  ttggggtct  gccatgaag  gcccactgc  cataatcct  180
ccaacacgc  gagaaatca  gtctcaagt  cttcccttc  tctgctgcc  ctctcaagg  240
agttttggg  ttccctaga  tagatgaca  agtaatgtg  tgggtatgg  ggctcctcc  300
ggcacacag  ccaaggctg  aggagcatc  tctactgtg  ccaacctgg  ctaaatagg  360
agatactat  acaaagaaa  aaaagcccc  agtgctcta  taatggaca  atattcaca  420
ctcgaagcc  cagtttccc  ttctgtaaa  tgaaggagc  gggtaggtc  ggatcagta  480
tttggctaa  ggtatgtgg  taagggata  a  511



<210> 6055
<211> 511
<212> DNA
<213> Rattus norvegicus
<308> AA893603
<400> 6055

ggagaccac  atttatttt  ggttaatgc  aaccaggaa  actactccc  tagtacagt  60
tgacacagg  tcctcagga  gacaacaat  gaaagcaag  gcatggcag  tttcctgtt  120
cagacctga  gtttgggag  ttggggtct  gccatgaag  gcccactgc  cataatcct  180
ccaacacgc  gagaaatca  gtctcaagt  cttcccttc  tctgctgcc  ctctcaagg  240
agttttggg  ttccctaga  tagatgaca  agtaatgtg  tgggtatgg  ggctcctcc  300
ggcacacag  ccaaggctg  aggagcatc  tctactgtg  ccaacctgg  ctaaatagg  360
agatactat  acaaagaaa  aaaagcccc  agtgctcta  taatggaca  atattcaca  420
ctcgaagcc  cagtttccc  ttctgtaaa  tgaaggagc  gggtaggtc  ggatcagta  480
tttggctaa  ggtatgtgg  taagggata  a  511



<210> 6056
<211> 298
<212> DNA
<213> Rattus norvegicus
<308> AA893612
<400> 6056

catgagaat  gccatttat  cccgaagtt  ccaaaatca  caccaagga  tcaccaggg  60
tgccaaggg  acgaggagg  tcaaacact  attgggggt  gtcagttta  agggagatg  120
gatgggtgg  ggaacccca  ctgtccctc  cccatctaa  gccacagaa  agggtcctc  180
tctggccgg  tcccctccc  atccccatg  ccagttttt  tcaagggga  gtgggttgg  240
gacttggga  gaggttgta  tgtgagtgg  ccccaggag  tggaagggc  ctgggggt  298



<210> 6057
<211> 212
<212> PRT
<213> Rattus norvegicus
<308> AAC97475
<400> 6057

Ser Ser Asp Pro Trp Ala Pro Ala Pro Ala Phe Ser Asp Pro Trp Gly 
  1               5                  10                  15
Gly Ser Pro Ala Lys Pro Ser Ser Asn Gly Thr Ala Ala Val Gly Gly 
             20                  25                  30
Phe Asp Thr Glu Pro Asp Glu Phe Ser Asp Phe Asp Arg Leu Arg Thr 
         35                  40                  45
Ala Leu Pro Thr Ser Gly Ser Ser Thr Gly Glu Leu Glu Leu Leu Ala 
     50                  55                  60
Gly Glu Val Pro Ala Arg Ser Pro Gly Ala Phe Asp Met Ser Gly Val 
 65                  70                  75                  80
Gly Gly Ser Leu Ala Glu Ser Val Gly Ser Pro Pro Pro Ala Ala Thr 
                 85                  90                  95
Pro Thr Pro Thr Pro Pro Thr Arg Lys Thr Pro Glu Ser Phe Leu Gly 
             100                105                110
Pro Asn Ala Ala Leu Val Asp Leu Asp Ser Leu Val Ser Arg Pro Gly 
         115                120                125
Pro Thr Pro Pro Gly Ser Lys Ala Ser Asn Pro Phe Leu Pro Ser Gly 
     130                135                140
Ala Pro Pro Thr Gly Pro Ser Val Thr Asn Pro Phe Gln Pro Ala Pro 
 145                150                155                160
Pro Ala Thr Leu Thr Leu Asn Gln Leu Arg Leu Ser Pro Val Pro Pro 
                 165                170                175
Val Pro Gly Ala Pro Pro Thr Tyr Ile Ser Pro Leu Gly Gly Gly Pro 
             180                185                190
Gly Leu Pro Pro Met Met Pro Pro Gly Pro Pro Ala Pro Asn Thr Asn 
         195                200                205
Pro Phe Leu Leu 
     210



<210> 6058
<211> 298
<212> DNA
<213> Rattus norvegicus
<308> AA893612
<400> 6058

catgagaat  gccatttat  cccgaagtt  ccaaaatca  caccaagga  tcaccaggg  60
tgccaaggg  acgaggagg  tcaaacact  attgggggt  gtcagttta  agggagatg  120
gatgggtgg  ggaacccca  ctgtccctc  cccatctaa  gccacagaa  agggtcctc  180
tctggccgg  tcccctccc  atccccatg  ccagttttt  tcaagggga  gtgggttgg  240
gacttggga  gaggttgta  tgtgagtgg  ccccaggag  tggaagggc  ctgggggt  298



<210> 6059
<211> 212
<212> PRT
<213> Rattus norvegicus
<308> AAC97475
<400> 6059

Ser Ser Asp Pro Trp Ala Pro Ala Pro Ala Phe Ser Asp Pro Trp Gly 
  1               5                  10                  15
Gly Ser Pro Ala Lys Pro Ser Ser Asn Gly Thr Ala Ala Val Gly Gly 
             20                  25                  30
Phe Asp Thr Glu Pro Asp Glu Phe Ser Asp Phe Asp Arg Leu Arg Thr 
         35                  40                  45
Ala Leu Pro Thr Ser Gly Ser Ser Thr Gly Glu Leu Glu Leu Leu Ala 
     50                  55                  60
Gly Glu Val Pro Ala Arg Ser Pro Gly Ala Phe Asp Met Ser Gly Val 
 65                  70                  75                  80
Gly Gly Ser Leu Ala Glu Ser Val Gly Ser Pro Pro Pro Ala Ala Thr 
                 85                  90                  95
Pro Thr Pro Thr Pro Pro Thr Arg Lys Thr Pro Glu Ser Phe Leu Gly 
             100                105                110
Pro Asn Ala Ala Leu Val Asp Leu Asp Ser Leu Val Ser Arg Pro Gly 
         115                120                125
Pro Thr Pro Pro Gly Ser Lys Ala Ser Asn Pro Phe Leu Pro Ser Gly 
     130                135                140
Ala Pro Pro Thr Gly Pro Ser Val Thr Asn Pro Phe Gln Pro Ala Pro 
 145                150                155                160
Pro Ala Thr Leu Thr Leu Asn Gln Leu Arg Leu Ser Pro Val Pro Pro 
                 165                170                175
Val Pro Gly Ala Pro Pro Thr Tyr Ile Ser Pro Leu Gly Gly Gly Pro 
             180                185                190
Gly Leu Pro Pro Met Met Pro Pro Gly Pro Pro Ala Pro Asn Thr Asn 
         195                200                205
Pro Phe Leu Leu 
     210



<210> 6060
<211> 607
<212> DNA
<213> Rattus norvegicus
<308> AA893621
<400> 6060

gcagacgcc  gtttattac  gaaggctag  caggactct  ctactagcc  agccagcgg  60
tgcccacaa  ggtcccaac  cagtcttcc  agagcaagg  agggctgcc  cacggtgga  120
atgggagca  tgttccctc  tggggcaat  gcggttttc  tgctcagtg  cagccaggg  180
aggcagtgg  taccagcac  gtcttctca  gagggcact  tcagcttcg  agtccccaa  240
aagaactgt  ggacacggt  agccaggag  gccaggccg  agtccaggg  caggacctg  300
ccgatgacc  gcttgaact  tacagggat  tccacgagg  caaactggc  gttgaagtc  360
ggggaggag  ccaggagca  gcccatgat  gccatcagt  acactgcca  actccacac  420
aagggcttg  tctcaggca  gctctccat  aagggtggg  ccttgtagt  gatggcaaa  480
gtagccatc  gcatggcca  ggccatgat  tacacagtg  tgttgacca  gctcggctc  540
aactccttg  acaggtcta  aaactgttc  tgcttctca  ggctgcgtg  ctgggcctc  600
cggtaca  607



<210> 6061
<211> 1200
<212> PRT
<213> Rattus norvegicus
<308> BAB20095
<400> 6061

Met Ala Val Val Gly Asn Ala Val Pro Cys Gly Ala Arg Pro Gly Gly 
  1               5                  10                  15
Ala Arg Asp Asn Gly Ser Pro Gln Pro Gly Ser Arg Leu Arg Pro Gly 
             20                  25                  30
Leu Ala Ala Gly Pro Ala Leu Ile Ala Asn Gly Asp Glu Leu Val Ala 
         35                  40                  45
Ala Val Trp Pro Tyr Arg Arg Leu Ala Leu Leu Arg Arg Leu Thr Val 
     50                  55                  60
Leu Pro Phe Ala Gly Leu Leu Tyr Pro Ala Trp Leu Gly Ala Ala Ala 
 65                  70                  75                  80
Ser Gly Cys Trp Gly Trp Gly Ser Ser Trp Thr Gln Ile Pro Glu Ala 
                 85                  90                  95
Ala Leu Leu Ala Leu Ala Thr Ile Cys Leu Ala His Ala Leu Thr Val 
             100                105                110
Leu Ser Gly His Trp Ser Val His Ala His Cys Ala Leu Thr Cys Thr 
         115                120                125
Pro Glu Tyr Asp Pro Asn Lys Val Thr Phe Val Lys Val Val Pro Thr 
     130                135                140
Pro Asn Asn Gly Ser Thr Glu Leu Val Ala Leu His Arg Asp Lys Gly 
 145                150                155                160
Glu Asp Gly Leu Glu Val Leu Ser Phe Glu Phe Gln Lys Ile Lys Tyr 
                 165                170                175
Ser Tyr Asp Ala Leu Glu Lys Lys Gln Phe Leu Ser Val Ala Phe Pro 
             180                185                190
Val Gly Asn Ala Phe Ser Tyr Tyr Gln Ser Asn Arg Gly Phe Gln Glu 
         195                200                205
Asp Ser Glu Ile Arg Ala Ala Glu Lys Lys Phe Gly Ser Asn Lys Ala 
     210                215                220
Glu Met Val Val Pro Asp Phe Ser Glu Leu Phe Lys Glu Arg Ala Thr 
 225                230                235                240
Ala Pro Phe Phe Val Phe Gln Val Phe Cys Val Gly Leu Trp Cys Leu 
                 245                250                255
Asp Glu Tyr Trp Tyr Tyr Ser Val Phe Thr Leu Ser Met Leu Val Ala 
             260                265                270
Phe Glu Ala Ser Leu Val Gln Gln Gln Met Arg Asn Met Ser Glu Ile 
         275                280                285
Arg Lys Met Gly Asn Lys Pro His Met Ile Gln Val Tyr Arg Ser Arg 
     290                295                300
Lys Trp Arg Pro Val Ala Ser Asp Asp Ile Val Pro Gly Asp Ile Val 
 305                310                315                320
Ser Ile Gly Arg Ser Pro Gln Glu Asn Leu Val Pro Cys Asp Val Leu 
                 325                330                335
Leu Leu Arg Gly Arg Cys Ile Val Asp Glu Ala Met Leu Thr Gly Glu 
             340                345                350
Ser Val Pro Gln Met Lys Glu Pro Ile Glu Asp Leu Ser Pro Asp Arg 
         355                360                365
Val Leu Asp Leu Gln Ala Asp Ala Arg Leu His Val Ile Phe Gly Gly 
     370                375                380
Thr Lys Val Val Gln His Ile Pro Pro Gln Lys Ala Thr Ser Gly Leu 
 385                390                395                400
Lys Pro Val Asp Asn Gly Cys Val Ala Phe Val Leu Arg Thr Gly Phe 
                 405                410                415
Asn Thr Ser Gln Gly Arg Leu Leu Arg Thr Ile Leu Phe Gly Val Lys 
             420                425                430
Arg Val Thr Ala Asn Asn Leu Glu Thr Phe Ile Phe Ile Leu Phe Leu 
         435                440                445
Leu Val Phe Ala Ile Ala Ala Ala Ala Tyr Val Trp Val Glu Gly Thr 
     450                455                460
Lys Asp Pro Ser Arg Asn Arg Tyr Lys Leu Phe Leu Glu Cys Thr Leu 
 465                470                475                480
Ile Leu Thr Ser Val Val Pro Pro Glu Leu Pro Ile Glu Leu Ser Leu 
                 485                490                495
Ala Val Asn Thr Ser Leu Ile Ala Leu Ala Lys Leu Tyr Met Tyr Cys 
             500                505                510
Thr Glu Pro Phe Arg Ile Pro Phe Ala Gly Lys Val Glu Val Cys Cys 
         515                520                525
Phe Asp Lys Thr Gly Thr Leu Thr Ser Asp Ser Leu Val Val Arg Gly 
     530                535                540
Val Ala Gly Leu Arg Asp Gly Lys Glu Val Thr Pro Val Ser Ser Ile 
 545                550                555                560
Pro Ile Glu Thr His Arg Ala Leu Ala Ser Cys His Ser Leu Met Gln 
                 565                570                575
Leu Asp Asp Gly Thr Leu Val Gly Asp Pro Leu Glu Lys Ala Met Leu 
             580                585                590
Thr Ala Val Asp Trp Thr Leu Thr Lys Asp Glu Lys Val Phe Pro Arg 
         595                600                605
Ser Ile Lys Thr Gln Gly Leu Lys Ile His Gln Arg Phe His Phe Ala 
     610                615                620
Ser Ala Leu Lys Arg Met Ser Val Leu Ala Ser Tyr Glu Lys Leu Gly 
 625                630                635                640
Ser Thr Asp Leu Cys Tyr Ile Ala Ala Val Lys Gly Ala Pro Glu Thr 
                 645                650                655
Leu His Ser Met Phe Ser Gln Cys Pro Pro Asp Tyr His His Ile His 
             660                665                670
Thr Glu Ile Ser Arg Glu Gly Ala Arg Val Leu Ala Leu Gly Tyr Lys 
         675                680                685
Glu Leu Gly His Leu Thr His Gln Gln Ala Arg Glu Ile Lys Arg Glu 
     690                695                700
Ala Leu Glu Cys Ser Leu Lys Phe Val Gly Phe Ile Val Val Ser Cys 
 705                710                715                720
Pro Leu Lys Ala Asp Ser Lys Ala Val Ile Arg Glu Ile Gln Asn Ala 
                 725                730                735
Ser His Arg Val Val Met Ile Thr Gly Asp Asn Pro Leu Thr Ala Cys 
             740                745                750
His Val Ala Gln Glu Leu His Phe Ile Asp Lys Ala His Thr Leu Ile 
         755                760                765
Leu His Pro Pro Ser Glu Lys Gly Gln Pro Cys Glu Trp Arg Ser Ile 
     770                775                780
Asp Ser Ser Ile Val Leu Pro Leu Thr Leu Gly Ser Pro Lys Ala Leu 
 785                790                795                800
Ala Leu Glu His Ala Leu Cys Leu Thr Gly Asp Gly Leu Ala His Leu 
                 805                810                815
Gln Ala Val Asp Pro Gln Gln Leu Leu Cys Leu Ile Pro His Val Gln 
             820                825                830
Val Phe Ala Arg Val Ala Pro Lys Gln Lys Glu Phe Val Ile Thr Ser 
         835                840                845
Leu Lys Glu Leu Gly Tyr Val Thr Leu Met Cys Gly Asp Gly Thr Asn 
     850                855                860
Asp Val Gly Ala Leu Lys His Ala Asp Val Gly Val Ala Leu Leu Ala 
 865                870                875                880
Asn Ala Pro Glu Arg Val Val Glu Arg Arg Arg Arg Pro Arg Asp Ser 
                 885                890                895
Pro Val Leu Ser Asn Ser Gly Pro Arg Val Ser Arg Ser Thr Lys Gln 
             900                905                910
Lys Ser Ala Leu Leu Ser Pro Glu Glu Pro Pro Ala Ser His Arg Asp 
         915                920                925
Arg Leu Ser Gln Val Leu Arg Asp Leu Glu Glu Glu Ser Thr Pro Ile 
     930                935                940
Val Lys Leu Gly Asp Ala Ser Ile Ala Ala Pro Phe Thr Ser Lys Leu 
 945                950                955                960
Ser Ser Ile Gln Cys Ile Cys His Val Ile Lys Gln Gly Arg Cys Thr 
                 965                970                975
Leu Val Thr Thr Leu Gln Met Phe Lys Ile Leu Ala Leu Asn Ala Leu 
             980                985                990
Ile Leu Ala Tyr Ser Gln Ser Val Leu Tyr Leu Glu Gly Val Lys Phe 
         995                1000                1005
Ser Asp Phe Gln Ala Thr Leu Gln Gly Leu Leu Leu Ala Gly Cys Phe 
     1010                1015                1020
Leu Phe Ile Ser Arg Ser Lys Pro Leu Lys Thr Leu Ser Arg Glu Arg 
 1025                1030                1035                1040
Pro Leu Pro Asn Ile Phe Asn Leu Tyr Thr Ile Leu Thr Val Met Leu 
                 1045                1050                1055
Gln Phe Ser Val His Phe Leu Ser Leu Val Tyr Leu Tyr Arg Glu Ala 
             1060                1065                1070
Gln Ala Arg Ser Pro Glu Lys Gln Glu Gln Phe Val Asp Leu Tyr Lys 
         1075                1080                1085
Glu Phe Glu Pro Ser Leu Val Asn Ser Thr Val Tyr Ile Met Ala Met 
     1090                1095                1100
Ala Met Gln Met Ala Thr Phe Ala Ile Asn Tyr Lys Gly Pro Pro Phe 
 1105                1110                1115                1120
Met Glu Ser Leu Pro Glu Asn Lys Pro Leu Val Trp Ser Leu Ala Val 
                 1125                1130                1135
Ser Leu Leu Ala Ile Ile Gly Leu Leu Leu Gly Ser Ser Pro Asp Phe 
             1140                1145                1150
Asn Ser Gln Phe Gly Leu Val Asp Ile Pro Val Glu Phe Lys Leu Val 
         1155                1160                1165
Ile Gly Gln Val Leu Ala Leu Asp Phe Cys Leu Ala Leu Leu Ala Asp 
     1170                1175                1180
Arg Val Leu Gln Phe Phe Leu Gly Thr Pro Lys Leu Arg Val Pro Ser 
 1185                1190                1195                1200



<210> 6062
<211> 3483
<212> DNA
<213> Homo sapiens
<308> NM_020410
<400> 6062

atggagaag  gggaggagc  gaacagcca  cagccagga  aggagtacg  ccccagcaa  60
gcgaccttt  tgaaggtgg  gccaacccc  aacaatggc  ccacggagc  cgtggccct  120
caccgcaat  agggcgaag  cgggcttga  gtgctgtcc  tcgaattcc  gaagatcaa  180
tattcctac  atgccctgg  gaagaagca  tttctcccc  tggcctttc  tgtgggaaa  240
gccttctca  actatcaga  caacagagg  ttccaggaa  actcagaga  ccgagcagc  300
gagaagaaa  ttgggagca  caaggccga  atggtggtg  ctgacttct  ggagctttt  360
aaggagaga  ccacagccc  cttctttgt  tttcaggtg  tctgtgtgg  gctctggtg  420
ctggatgag  actggtact  cagcgtctt  acgctatcc  tgctggtgg  gttcgaggc  480
tcgctggtg  agcagcaga  gcggaacat  tcggagatc  ggaagatgg  caacaagcc  540
cacatgatc  aggtctacc  aagccgcaa  tggaggccc  ttgccagtg  tgagatcgt  600
ccaggggac  tcgtctcca  cggccgctc  ccacaggag  acctggtgc  atgtgacgt  660
cttctgctg  gaggccgct  catcgtaga  gaggccatg  tcacggggg  gtccgtgcc  720
cagatgaag  agcccatcg  agacctcag  ccagaccgg  tgctggacc  ccaggctga  780
tcccggctg  acgtcatct  cgggggcac  aaggtggtg  agcacatcc  cccacagaa  840
gccaccacg  gcctgaagc  ggttgacag  gggtgcgtg  cctacgtcc  gcggaccgg  900
ttcaacaca  cccagggca  gctgctgcg  accatcctc  tcggggtca  gagggtgac  960
gcgaacaac  tggagacct  catcttcat  ctcttcctc  tggtgtttg  catcgctgc  1020
gctgcctat  tatggattg  aggtaccaa  gaccccagc  ggaaccgct  caagctgtt  1080
ctggagtgc  ccctgatcc  cacctcggt  gtgcctcct  agctgccca  cgagctgtc  1140
ctggccgtc  acacctccc  catcgccct  gccaagctc  acatgtact  cacagagcc  1200
ttccggatc  cctttgctg  caaggtcga  gtgtgctgc  ttgacaaga  ggggacgtt  1260
accagtgac  gcctggtgg  gcgcggtgt  gccgggctg  gagacggga  ggaggtgac  1320
ccagtgtcc  gcatccctg  agaaacaca  cgggccctg  cctcgtgcc  ctcgctcat  1380
cagctggac  acggcaccc  cgtgggtga  cctctagag  aggccatgc  gacggccgt  1440
gactggacg  tgaccaaag  tgagaaagt  ttcccccga  gtattaaaa  tcaggggct  1500
aaaattcac  agcgctttc  ttttgccag  gccctgaag  gaatgtccg  gcttgcctc  1560
tatgagaag  tgggctcca  cgacctctg  tacatcgcg  ccgtgaagg  ggcccccga  1620
actctgcac  ccatgttct  ccagtgccc  cccgactac  accacatcc  caccgagat  1680
tcccgggaa  gagcccgcg  cctggcgct  gggtacaag  agctgggac  cctcactca  1740
cagcaggcc  gggaggtca  gcgggaggc  ctggagtgc  gcctcaagt  cgtcggctt  1800
attgtggtc  cctgcccgc  caaggctga  tccaaggcc  tgatccggg  gatccagaa  1860
gcgtcccac  gggtggtca  gatcacggg  gacaacccg  tcactgcat  ccacgtggc  1920
caggagctg  acttcattg  aaaggccca  acgctgatc  tgcagcctc  ctccgagaa  1980
ggccggcag  gcgagtggc  ctccattga  ggcagcatc  tgctgcccc  ggcccgggg  2040
tccccaaag  cactggccc  ggagtacgc  ctgtgcctc  caggcgacg  cttggccca  2100
ctgcaggcc  ccgaccccc  gcagctgct  cgcctcatc  cccatgtgc  ggtgttcgc  2160
cgtgtggct  ccaagcaga  ggagtttgt  atcaccagc  tgaaggagc  gggctacgt  2220
accctcatg  gtggggatg  caccaacga  gtgggcgcc  tgaagcatg  tgacgtggg  2280
gtggcgctc  tggccaatg  ccctgagcg  gttgtcgag  ggcgacggc  gccccggga  2340
agcccaacc  tgagcaaca  tggcatcag  gccacctcc  ggacagcca  gcagcggtc  2400
gggctccct  cctccgagg  gcagccaac  tcccagagg  accgcctga  ccaggtgct  2460
cgagacctc  aggacgaga  tacgcccat  gtgaaactg  gggatgcca  catcgcagc  2520
cccttcacc  ccaagctct  atccatcca  tgcatctgc  acgtgatca  gcagggccg  2580
tgcacgctg  tgaccacgc  acagatgtt  aagatcctg  cgctcaatg  cctcatcct  2640
gcctacagc  agagcgtcc  ctacctgga  ggagtcaag  tcagtgact  ccaggccac  2700
ctacagggg  tgctgctgg  cggctgctt  ctcttcatc  cccgttcca  gcccctcaa  2760
accctctcc  gagaacggc  cctgcccaa  atcttcaac  tgtacacca  cctcaccgt  2820
atgctccag  tctttgtgc  cttcctgag  cttgtctac  tgtaccgtg  ggcccaggc  2880
cggagcccc  agaagcagg  gcagttcgt  gacttgtac  aggagtttg  gccaagcct  2940
gtcaacagc  ccgtctaca  catggccat  gccatgcag  tggccacct  cgccatcaa  3000
tacaaaggc  cgcccttca  ggagagcct  cccgagaac  agcccctgg  gtggagtct  3060
gcagtttca  tcctggcca  cattggcct  ctcctcggc  cctcgcccg  cttcaacag  3120
cagtttggc  tcgtggaca  ccctgtgga  ttcaagctg  tcattgccc  ggtcctgct  3180
ctggacttc  gcctggcgc  cctggccga  cgcgtcctg  agttcttcc  ggggacccc  3240
aagctgaaa  tgccttcct  agatggcag  gctggtacc  actgcccac  ctggctgcc  3300
ctgggcggg  accccaaca  ggccccggg  gggaaccct  cccccaacc  cccacagca  3360
ggctgtaca  tctcgccct  ggaagactg  gctgggacc  ccacagcca  ccgctggct  3420
ggccagcag  accagcccc  agccagcac  tttggtaaa  aaagcagca  ctgagattt  3480
aaa  3483



<210> 6063
<211> 1204
<212> PRT
<213> Homo sapiens
<308> Q9HD20
<400> 6063

Met Ala Ala Ala Ala Ala Val Gly Asn Ala Val Pro Cys Gly Ala Arg 
  1               5                  10                  15
Pro Cys Gly Val Arg Pro Asp Gly Gln Pro Lys Pro Gly Pro Gln Pro 
             20                  25                  30
Arg Ala Leu Leu Ala Ala Gly Pro Ala Leu Ile Ala Asn Gly Asp Glu 
         35                  40                  45
Leu Val Ala Ala Val Trp Pro Tyr Arg Arg Leu Ala Leu Leu Arg Arg 
     50                  55                  60
Leu Thr Val Leu Pro Phe Ala Gly Leu Leu Tyr Pro Ala Trp Leu Gly 
 65                  70                  75                  80
Ala Ala Ala Ala Gly Cys Trp Gly Trp Gly Ser Ser Trp Val Gln Ile 
                 85                  90                  95
Pro Glu Ala Ala Leu Leu Val Leu Ala Thr Ile Cys Leu Ala His Ala 
             100                105                110
Leu Thr Val Leu Ser Gly His Trp Ser Val His Ala His Cys Ala Leu 
         115                120                125
Thr Cys Thr Pro Glu Tyr Asp Pro Ser Lys Ala Thr Phe Val Lys Val 
     130                135                140
Val Pro Thr Pro Asn Asn Gly Ser Thr Glu Leu Val Ala Leu His Arg 
 145                150                155                160
Asn Glu Gly Glu Asp Gly Leu Glu Val Leu Ser Phe Glu Phe Gln Lys 
                 165                170                175
Ile Lys Tyr Ser Tyr Asp Ala Leu Glu Lys Lys Gln Phe Leu Pro Val 
             180                185                190
Ala Phe Pro Val Gly Asn Ala Phe Ser Tyr Tyr Gln Ser Asn Arg Gly 
         195                200                205
Phe Gln Glu Asp Ser Glu Ile Arg Ala Ala Glu Lys Lys Phe Gly Ser 
     210                215                220
Asn Lys Ala Glu Met Val Val Pro Asp Phe Ser Glu Leu Phe Lys Glu 
 225                230                235                240
Arg Ala Thr Ala Pro Phe Phe Val Phe Gln Val Phe Cys Val Gly Leu 
                 245                250                255
Trp Cys Leu Asp Glu Tyr Trp Tyr Tyr Ser Val Phe Thr Leu Ser Met 
             260                265                270
Leu Val Ala Phe Glu Ala Ser Leu Val Gln Gln Gln Met Arg Asn Met 
         275                280                285
Ser Glu Ile Arg Lys Met Gly Asn Lys Pro His Met Ile Gln Val Tyr 
     290                295                300
Arg Ser Arg Lys Trp Arg Pro Ile Ala Ser Asp Glu Ile Val Pro Gly 
 305                310                315                320
Asp Ile Val Ser Ile Gly Arg Ser Pro Gln Glu Asn Leu Val Pro Cys 
                 325                330                335
Asp Val Leu Leu Leu Arg Gly Arg Cys Ile Val Asp Glu Ala Met Leu 
             340                345                350
Thr Gly Glu Ser Val Pro Gln Met Lys Glu Pro Ile Glu Asp Leu Ser 
         355                360                365
Pro Asp Arg Val Leu Asp Leu Gln Ala Asp Ser Arg Leu His Val Ile 
     370                375                380
Phe Gly Gly Thr Lys Val Val Gln His Ile Pro Pro Gln Lys Ala Thr 
 385                390                395                400
Thr Gly Leu Lys Pro Val Asp Ser Gly Cys Val Ala Tyr Val Leu Arg 
                 405                410                415
Thr Gly Phe Asn Thr Ser Gln Gly Lys Leu Leu Arg Thr Ile Leu Phe 
             420                425                430
Gly Val Lys Arg Val Thr Ala Asn Asn Leu Glu Thr Phe Ile Phe Ile 
         435                440                445
Leu Phe Leu Leu Val Phe Ala Ile Ala Ala Ala Ala Tyr Val Trp Ile 
     450                455                460
Glu Gly Thr Lys Asp Pro Ser Arg Asn Arg Tyr Lys Leu Phe Leu Glu 
 465                470                475                480
Cys Thr Leu Ile Leu Thr Ser Val Val Pro Pro Glu Leu Pro Ile Glu 
                 485                490                495
Leu Ser Leu Ala Val Asn Thr Ser Leu Ile Ala Leu Ala Lys Leu Tyr 
             500                505                510
Met Tyr Cys Thr Glu Pro Phe Arg Ile Pro Phe Ala Gly Lys Val Glu 
         515                520                525
Val Cys Cys Phe Asp Lys Thr Gly Thr Leu Thr Ser Asp Ser Leu Val 
     530                535                540
Val Arg Gly Val Ala Gly Leu Arg Asp Gly Lys Glu Val Thr Pro Val 
 545                550                555                560
Ser Ser Ile Pro Val Glu Thr His Arg Ala Leu Ala Ser Cys His Ser 
                 565                570                575
Leu Met Gln Leu Asp Asp Gly Thr Leu Val Gly Asp Pro Leu Glu Lys 
             580                585                590
Ala Met Leu Thr Ala Val Asp Trp Thr Leu Thr Lys Asp Glu Lys Val 
         595                600                605
Phe Pro Arg Ser Ile Lys Thr Gln Gly Leu Lys Ile His Gln Arg Phe 
     610                615                620
His Phe Ala Ser Ala Leu Lys Arg Met Ser Val Leu Ala Ser Tyr Glu 
 625                630                635                640
Lys Leu Gly Ser Thr Asp Leu Cys Tyr Ile Ala Ala Val Lys Gly Ala 
                 645                650                655
Pro Glu Thr Leu His Ser Met Phe Ser Gln Cys Pro Pro Asp Tyr His 
             660                665                670
His Ile His Thr Glu Ile Ser Arg Glu Gly Ala Arg Val Leu Ala Leu 
         675                680                685
Gly Tyr Lys Glu Leu Gly His Leu Thr His Gln Gln Ala Arg Glu Val 
     690                695                700
Lys Arg Glu Ala Leu Glu Cys Ser Leu Lys Phe Val Gly Phe Ile Val 
 705                710                715                720
Val Ser Cys Pro Leu Lys Ala Asp Ser Lys Ala Val Ile Arg Glu Ile 
                 725                730                735
Gln Asn Ala Ser His Arg Val Val Met Ile Thr Gly Asp Asn Pro Leu 
             740                745                750
Thr Ala Cys His Val Ala Gln Glu Leu His Phe Ile Glu Lys Ala His 
         755                760                765
Thr Leu Ile Leu Gln Pro Pro Ser Glu Lys Gly Arg Gln Cys Glu Trp 
     770                775                780
Arg Ser Ile Asp Gly Ser Ile Val Leu Pro Leu Ala Arg Gly Ser Pro 
 785                790                795                800
Lys Ala Leu Ala Leu Glu Tyr Ala Leu Cys Leu Thr Gly Asp Gly Leu 
                 805                810                815
Ala His Leu Gln Ala Thr Asp Pro Gln Gln Leu Leu Arg Leu Ile Pro 
             820                825                830
His Val Gln Val Phe Ala Arg Val Ala Pro Lys Gln Lys Glu Phe Val 
         835                840                845
Ile Thr Ser Leu Lys Glu Leu Gly Tyr Val Thr Leu Met Cys Gly Asp 
     850                855                860
Gly Thr Asn Asp Val Gly Ala Leu Lys His Ala Asp Val Gly Val Ala 
 865                870                875                880
Leu Leu Ala Asn Ala Pro Glu Arg Val Val Glu Arg Arg Arg Arg Pro 
                 885                890                895
Arg Asp Ser Pro Thr Leu Ser Asn Ser Gly Ile Arg Ala Thr Ser Arg 
             900                905                910
Thr Ala Lys Gln Arg Ser Gly Leu Pro Pro Ser Glu Glu Gln Pro Thr 
         915                920                925
Ser Gln Arg Asp Arg Leu Ser Gln Val Leu Arg Asp Leu Glu Asp Glu 
     930                935                940
Ser Thr Pro Ile Val Lys Leu Gly Asp Ala Ser Ile Ala Ala Pro Phe 
 945                950                955                960
Thr Ser Lys Leu Ser Ser Ile Gln Cys Ile Cys His Val Ile Lys Gln 
                 965                970                975
Gly Arg Cys Thr Leu Val Thr Thr Leu Gln Met Phe Lys Ile Leu Ala 
             980                985                990
Leu Asn Ala Leu Ile Leu Ala Tyr Ser Gln Ser Val Leu Tyr Leu Glu 
         995                1000                1005
Gly Val Lys Phe Ser Asp Phe Gln Ala Thr Leu Gln Gly Leu Leu Leu 
     1010                1015                1020
Ala Gly Cys Phe Leu Phe Ile Ser Arg Ser Lys Pro Leu Lys Thr Leu 
 1025                1030                1035                1040
Ser Arg Glu Arg Pro Leu Pro Asn Ile Phe Asn Leu Tyr Thr Ile Leu 
                 1045                1050                1055
Thr Val Met Leu Gln Phe Phe Val His Phe Leu Ser Leu Val Tyr Leu 
             1060                1065                1070
Tyr Arg Glu Ala Gln Ala Arg Ser Pro Glu Lys Gln Glu Gln Phe Val 
         1075                1080                1085
Asp Leu Tyr Lys Glu Phe Glu Pro Ser Leu Val Asn Ser Thr Val Tyr 
     1090                1095                1100
Ile Met Ala Met Ala Met Gln Met Ala Thr Phe Ala Ile Asn Tyr Lys 
 1105                1110                1115                1120
Gly Pro Pro Phe Met Glu Ser Leu Pro Glu Asn Lys Pro Leu Val Trp 
                 1125                1130                1135
Ser Leu Ala Val Ser Leu Leu Ala Ile Ile Gly Leu Leu Leu Gly Ser 
             1140                1145                1150
Ser Pro Asp Phe Asn Ser Gln Phe Gly Leu Val Asp Ile Pro Val Glu 
         1155                1160                1165
Phe Lys Leu Val Ile Ala Gln Val Leu Leu Leu Asp Phe Cys Leu Ala 
     1170                1175                1180
Leu Leu Ala Asp Arg Val Leu Gln Phe Phe Leu Gly Thr Pro Lys Leu 
 1185                1190                1195                1200
Lys Val Pro Ser 
                 1205



<210> 6064
<211> 508
<212> DNA
<213> Rattus norvegicus
<308> AA893641
<400> 6064

acagtcttg  cccaaactc  ttattctgt  cctcagaaa  ctcagattt  taccttgtc  60
tacaacttg  gccttcatc  aattactaa  ccagtggtt  tcactgact  agtggtcac  120
accagtgag  cttgggtat  tggatactg  agtgggtgg  tgagccagg  ccaagaatt  180
agaagaggc  actgaccct  tgctcagtg  ggccagaag  agaaaccat  atgcttggt  240
tgttttctg  catacttaa  caatttcaa  agattctag  atgtttgaa  cacagcata  300
gccccacat  cgggctctg  gctggtacc  gcccagcca  gcttacacc  tgtgcaccc  360
gctcagcta  cgccctcac  catgcacgc  catttatgt  ccaaggcaa  tctgcccat  420
gctgcagcc  catccaaga  acaacttca  ttgtggaaa  gaaaggtgg  ttccctgtc  480
tcacagagg  taagactac  acagtcct  508



<210> 6065
<211> 379
<212> PRT
<213> Rattus norvegicus
<308> Q9QXQ7
<400> 6065

Met Lys Lys Pro Ile Gly Ile Leu Ser Pro Gly Val Ala Leu Gly Thr 
  1               5                  10                  15
Ala Gly Gly Ala Met Ser Ser Lys Phe Phe Leu Met Ala Leu Ala Thr 
             20                  25                  30
Phe Phe Ser Phe Ala Gln Val Val Ile Lys Ala Asn Ser Trp Trp Ser 
         35                  40                  45
Leu Ser Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile Gly 
     50                  55                  60
Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln Lys 
 65                  70                  75                  80
Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu Gly 
                 85                  90                  95
Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg Arg 
             100                105                110
Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val Met 
         115                120                125
Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala Ala 
     130                135                140
Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu Ser 
 145                150                155                160
Thr Cys Gly Cys Ser Arg Ala Arg Pro Lys Asp Leu Pro Arg Asp Trp 
                 165                170                175
Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg Phe Ala 
             180                185                190
Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala Lys Gly 
         195                200                205
Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn Glu Ala 
     210                215                220
Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys Cys His 
 225                230                235                240
Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln Leu Ala 
                 245                250                255
Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp Ser Ala 
             260                265                270
Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val Asn Ser 
         275                280                285
Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp Pro Ser 
     290                295                300
Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly Thr Gln 
 305                310                315                320
Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys Glu Leu 
                 325                330                335
Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln Thr Glu 
             340                345                350
Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Lys Lys 
         355                360                365
Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys 
     370                375



<210> 6066
<211> 2457
<212> DNA
<213> Homo sapiens
<308> AL390088
<400> 6066

cggggccgg  gaactgcgg  ccggaacgg  tgaggaagg  cccgtcccg  cttccccgg  60
gcgccatgg  gccccgggc  gttgcagaa  ccgtggaga  gggtgagga  gatgtgatt  120
tggaagctc  gcggtcata  aaccaggag  actcccaga  cttcacgtt  gatgatgcc  180
aacaggagg  ccggaagag  ctggcggag  tgctggtct  cgtcctgga  cagggcttg  240
caccctccc  ccgtgtcat  tggctgcag  gtgtccgaa  cctgtcccg  gaccgcaac  300
gcctggacc  gttcaccag  cgccagagc  tgcaggcac  agcctgcta  gctgacatc  360
ctgtctctg  ggggtccgt  ccagagtcc  cagacatgg  tgttgtact  gagtccctc  420
agtgcctgt  caacctcgt  ctcagcagc  ctgtggcac  gatgctggc  gcagaggcc  480
gcctagtgg  gaagctcac  gagcgtgtg  ggctgtacc  tgagaggag  ttcccccac  540
atgtccagt  ctttgactt  cggctcctc  tcctgctaa  ggcactccg  accgatgtg  600
gccagcagc  gtttcagga  ctgaaagga  tgcgcctgc  aactgacac  ctggagctg  660
cgctggggg  gactcctga  gggaacccc  cacccacgc  ccttccttc  caagagact  720
agcgggcca  ggagatcct  aaagtgctc  tcaacatca  cctggactc  atcaagggg  780
aggtggacg  ggaagacgc  gccctttac  gacacctgg  gacccttct  cggcactgt  840
tgatgatcg  tactgctgg  gaccgcaca  aggagttcc  cggccacgc  gtgaacctc  900
tggggaact  gcccctcaa  tgtctggat  ttctcctca  cctggagcc  catggagac  960
ccacggagt  catgggagt  aatatggat  tgattcgtg  cctcctcat  ttcctagag  1020
agcgtttgc  caagacaca  aggctgaag  agagtgtag  tcccgtgct  agcgtgctg  1080
ctgaatgtg  ccggatgca  cgcccagcc  ggaagttcc  gaaggccca  gtgctgccc  1140
ctctgcggg  tgtgaggac  cggcctgag  ttggggaga  gctgcggaa  aagcttgtc  1200
gcctcatga  acacctgga  acagatgtg  agagggtgg  tgccgagtt  ttgtttgtc  1260
tgtgctctg  gagtgtgcc  cgattcatc  agtacacag  ctatgggaa  gctgctggc  1320
ttctggctg  caggggcct  atggcagga  gccggcccg  gggccagta  tcagaggat  1380
aggacacag  cacagatga  tacaaggaa  ccaaagcca  cataaaccc  gtgaccggg  1440
gggtggagg  gaagccgcc  aaccctatg  agggcatga  agaggagca  aaggagcac  1500
aggccatga  gctggtgac  atgtttgac  agctctcca  gaacagagt  atccagcca  1560
tggggatga  tccccgggg  catcttacg  ccctgcagg  tgccatgtg  gagactatg  1620
agcagcagc  ctcctcgga  cctgactcg  accctgact  aggatggca  ctcttctgc  1680
cccccatca  gactggtgc  gcttccaga  acttccttg  ggttgcaac  tcgggaagc  1740
acatcccac  ggatccaca  ccgccccca  ttctccatc  tagaaaccc  ttctcttga  1800
tcccgttct  ttcatgatt  gcctctggt  cagtttctc  tctctggac  gcaacggtc  1860
tcttgtgct  gaactcagg  tcagcctcg  attccacag  cgaagtact  tcttttgtc  1920
gcgccaaga  gaatgtgtt  agaagctgc  gcctgaggg  agggcctac  tgggcacac  1980
gaagagcat  tgggagggc  ggggtttgg  tgtgggtgc  cacaaagca  gcaccatct  2040
ggattggca  actggcaga  ccagtgtgt  ggggtatgt  ctgcacttc  cagggagaa  2100
acctgtcag  actttccat  cgagtatat  agaacacac  cttccaagg  atgtatgct  2160
tgttgttcc  gtcctgtct  cactgagcg  agggctgga  gcctcttag  cattctcct  2220
ggtcctcgt  cagctgccc  ctgtagtat  cacagtgcc  gagttctcg  tggttttgg  2280
aattaaacc  ccttcctac  ggtttagac  acacttaca  caaggaaaa  gcccctcgt  2340
tgaccatag  ttgagattt  taccacata  cacacatag  cacagaaac  tcatcttga  2400
ataaagaag  gttttggac  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaa  2457



<210> 6067
<211> 365
<212> PRT
<213> Homo sapiens
<308> P41221
<400> 6067

Met Ala Gly Ser Ala Met Ser Ser Lys Phe Phe Leu Val Ala Leu Ala 
  1               5                  10                  15
Ile Phe Phe Ser Phe Ala Gln Val Val Ile Glu Ala Asn Ser Trp Trp 
             20                  25                  30
Ser Leu Gly Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile 
         35                  40                  45
Gly Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln 
     50                  55                  60
Lys Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu 
 65                  70                  75                  80
Gly Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg 
                 85                  90                  95
Arg Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val 
             100                105                110
Met Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala 
         115                120                125
Ala Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu 
     130                135                140
Ser Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys Asp Leu Pro Arg 
 145                150                155                160
Asp Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg 
                 165                170                175
Phe Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala 
             180                185                190
Lys Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn 
         195                200                205
Glu Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys 
     210                215                220
Cys His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln 
 225                230                235                240
Leu Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp 
                 245                250                255
Ser Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val 
             260                265                270
Asn Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp 
         275                280                285
Pro Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly 
     290                295                300
Thr Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys 
 305                310                315                320
Glu Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln 
                 325                330                335
Thr Glu Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
             340                345                350
Lys Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys 
         355                360                365



<210> 6068
<211> 508
<212> DNA
<213> Rattus norvegicus
<308> AA893641
<400> 6068

acagtcttg  cccaaactc  ttattctgt  cctcagaaa  ctcagattt  taccttgtc  60
tacaacttg  gccttcatc  aattactaa  ccagtggtt  tcactgact  agtggtcac  120
accagtgag  cttgggtat  tggatactg  agtgggtgg  tgagccagg  ccaagaatt  180
agaagaggc  actgaccct  tgctcagtg  ggccagaag  agaaaccat  atgcttggt  240
tgttttctg  catacttaa  caatttcaa  agattctag  atgtttgaa  cacagcata  300
gccccacat  cgggctctg  gctggtacc  gcccagcca  gcttacacc  tgtgcaccc  360
gctcagcta  cgccctcac  catgcacgc  catttatgt  ccaaggcaa  tctgcccat  420
gctgcagcc  catccaaga  acaacttca  ttgtggaaa  gaaaggtgg  ttccctgtc  480
tcacagagg  taagactac  acagtcct  508



<210> 6069
<211> 379
<212> PRT
<213> Rattus norvegicus
<308> Q9QXQ7
<400> 6069

Met Lys Lys Pro Ile Gly Ile Leu Ser Pro Gly Val Ala Leu Gly Thr 
  1               5                  10                  15
Ala Gly Gly Ala Met Ser Ser Lys Phe Phe Leu Met Ala Leu Ala Thr 
             20                  25                  30
Phe Phe Ser Phe Ala Gln Val Val Ile Lys Ala Asn Ser Trp Trp Ser 
         35                  40                  45
Leu Ser Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile Gly 
     50                  55                  60
Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln Lys 
 65                  70                  75                  80
Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu Gly 
                 85                  90                  95
Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg Arg 
             100                105                110
Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val Met 
         115                120                125
Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala Ala 
     130                135                140
Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu Ser 
 145                150                155                160
Thr Cys Gly Cys Ser Arg Ala Arg Pro Lys Asp Leu Pro Arg Asp Trp 
                 165                170                175
Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg Phe Ala 
             180                185                190
Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala Lys Gly 
         195                200                205
Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn Glu Ala 
     210                215                220
Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys Cys His 
 225                230                235                240
Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln Leu Ala 
                 245                250                255
Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp Ser Ala 
             260                265                270
Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val Asn Ser 
         275                280                285
Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp Pro Ser 
     290                295                300
Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly Thr Gln 
 305                310                315                320
Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys Glu Leu 
                 325                330                335
Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln Thr Glu 
             340                345                350
Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Lys Lys 
         355                360                365
Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys 
     370                375



<210> 6070
<211> 2457
<212> DNA
<213> Homo sapiens
<308> AL390088
<400> 6070

cggggccgg  gaactgcgg  ccggaacgg  tgaggaagg  cccgtcccg  cttccccgg  60
gcgccatgg  gccccgggc  gttgcagaa  ccgtggaga  gggtgagga  gatgtgatt  120
tggaagctc  gcggtcata  aaccaggag  actcccaga  cttcacgtt  gatgatgcc  180
aacaggagg  ccggaagag  ctggcggag  tgctggtct  cgtcctgga  cagggcttg  240
caccctccc  ccgtgtcat  tggctgcag  gtgtccgaa  cctgtcccg  gaccgcaac  300
gcctggacc  gttcaccag  cgccagagc  tgcaggcac  agcctgcta  gctgacatc  360
ctgtctctg  ggggtccgt  ccagagtcc  cagacatgg  tgttgtact  gagtccctc  420
agtgcctgt  caacctcgt  ctcagcagc  ctgtggcac  gatgctggc  gcagaggcc  480
gcctagtgg  gaagctcac  gagcgtgtg  ggctgtacc  tgagaggag  ttcccccac  540
atgtccagt  ctttgactt  cggctcctc  tcctgctaa  ggcactccg  accgatgtg  600
gccagcagc  gtttcagga  ctgaaagga  tgcgcctgc  aactgacac  ctggagctg  660
cgctggggg  gactcctga  gggaacccc  cacccacgc  ccttccttc  caagagact  720
agcgggcca  ggagatcct  aaagtgctc  tcaacatca  cctggactc  atcaagggg  780
aggtggacg  ggaagacgc  gccctttac  gacacctgg  gacccttct  cggcactgt  840
tgatgatcg  tactgctgg  gaccgcaca  aggagttcc  cggccacgc  gtgaacctc  900
tggggaact  gcccctcaa  tgtctggat  ttctcctca  cctggagcc  catggagac  960
ccacggagt  catgggagt  aatatggat  tgattcgtg  cctcctcat  ttcctagag  1020
agcgtttgc  caagacaca  aggctgaag  agagtgtag  tcccgtgct  agcgtgctg  1080
ctgaatgtg  ccggatgca  cgcccagcc  ggaagttcc  gaaggccca  gtgctgccc  1140
ctctgcggg  tgtgaggac  cggcctgag  ttggggaga  gctgcggaa  aagcttgtc  1200
gcctcatga  acacctgga  acagatgtg  agagggtgg  tgccgagtt  ttgtttgtc  1260
tgtgctctg  gagtgtgcc  cgattcatc  agtacacag  ctatgggaa  gctgctggc  1320
ttctggctg  caggggcct  atggcagga  gccggcccg  gggccagta  tcagaggat  1380
aggacacag  cacagatga  tacaaggaa  ccaaagcca  cataaaccc  gtgaccggg  1440
gggtggagg  gaagccgcc  aaccctatg  agggcatga  agaggagca  aaggagcac  1500
aggccatga  gctggtgac  atgtttgac  agctctcca  gaacagagt  atccagcca  1560
tggggatga  tccccgggg  catcttacg  ccctgcagg  tgccatgtg  gagactatg  1620
agcagcagc  ctcctcgga  cctgactcg  accctgact  aggatggca  ctcttctgc  1680
cccccatca  gactggtgc  gcttccaga  acttccttg  ggttgcaac  tcgggaagc  1740
acatcccac  ggatccaca  ccgccccca  ttctccatc  tagaaaccc  ttctcttga  1800
tcccgttct  ttcatgatt  gcctctggt  cagtttctc  tctctggac  gcaacggtc  1860
tcttgtgct  gaactcagg  tcagcctcg  attccacag  cgaagtact  tcttttgtc  1920
gcgccaaga  gaatgtgtt  agaagctgc  gcctgaggg  agggcctac  tgggcacac  1980
gaagagcat  tgggagggc  ggggtttgg  tgtgggtgc  cacaaagca  gcaccatct  2040
ggattggca  actggcaga  ccagtgtgt  ggggtatgt  ctgcacttc  cagggagaa  2100
acctgtcag  actttccat  cgagtatat  agaacacac  cttccaagg  atgtatgct  2160
tgttgttcc  gtcctgtct  cactgagcg  agggctgga  gcctcttag  cattctcct  2220
ggtcctcgt  cagctgccc  ctgtagtat  cacagtgcc  gagttctcg  tggttttgg  2280
aattaaacc  ccttcctac  ggtttagac  acacttaca  caaggaaaa  gcccctcgt  2340
tgaccatag  ttgagattt  taccacata  cacacatag  cacagaaac  tcatcttga  2400
ataaagaag  gttttggac  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaa  2457



<210> 6071
<211> 365
<212> PRT
<213> Homo sapiens
<308> P41221
<400> 6071

Met Ala Gly Ser Ala Met Ser Ser Lys Phe Phe Leu Val Ala Leu Ala 
  1               5                  10                  15
Ile Phe Phe Ser Phe Ala Gln Val Val Ile Glu Ala Asn Ser Trp Trp 
             20                  25                  30
Ser Leu Gly Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile 
         35                  40                  45
Gly Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln 
     50                  55                  60
Lys Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu 
 65                  70                  75                  80
Gly Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg 
                 85                  90                  95
Arg Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val 
             100                105                110
Met Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala 
         115                120                125
Ala Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu 
     130                135                140
Ser Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys Asp Leu Pro Arg 
 145                150                155                160
Asp Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg 
                 165                170                175
Phe Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala 
             180                185                190
Lys Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn 
         195                200                205
Glu Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys 
     210                215                220
Cys His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln 
 225                230                235                240
Leu Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp 
                 245                250                255
Ser Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val 
             260                265                270
Asn Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp 
         275                280                285
Pro Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly 
     290                295                300
Thr Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys 
 305                310                315                320
Glu Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln 
                 325                330                335
Thr Glu Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
             340                345                350
Lys Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys 
         355                360                365



<210> 6072
<211> 457
<212> DNA
<213> Rattus norvegicus
<308> AA893662
<400> 6072

gagttataa  aaagagata  ttattttag  tcacagatc  gtctttaaa  ggaaaccac  60
caacagttg  actaaagag  aatctgaca  ataatccca  caataaagt  tgatacaat  120
aaagggcat  aaggccatc  gactcacaa  tgtgaaaga  agcattaat  agaaacaat  180
caatattaa  aagctctaa  catgatggg  ccctgagga  gaattgaag  cttctgtta  240
aaccttcag  ggggcctca  taaaagaaa  aatgagaaa  tgtgtgtaa  ggtcataac  300
tccataaga  agatgtgct  gtttgatga  aatgaccca  acaggctca  atgtttgaa  360
acttggctc  agttgatgg  actgttcgg  aaggattan  aggtgtggt  tcgctagga  420
agacacatc  cttgggggg  atgcttcga  gtttcan  457



<210> 6073
<211> 496
<212> DNA
<213> Rattus norvegicus
<308> AA893663
<400> 6073

gaaaaacaa  gaatttaat  tattttaca  ttgtacaaa  gataaagca  gaatagctc  60
ttgctatgc  caaacaaca  aagacattg  tgaccagaa  gaacctaca  agtgagctt  120
atccttcct  tctacggat  gtagaagaa  gacacagca  ttatcctat  cagcaaagc  180
atctgtaaa  tctgttttg  ttttcttct  ctggctatg  acatctaaa  ctcttgtgc  240
ttcaccaac  caaacaaaa  agtattctg  aaaaggcgc  acataaagg  gaaacacac  300
gcctagacc  acagtcaga  aaccgcaat  taaatacat  gccagcttg  aggtaattt  360
tttcccttt  cttttgttt  gaaaggctt  aacagacta  ttgctgact  tttctctag  420
aaagaacat  taattcagc  acgaagtgg  tctttctta  agcagagta  taagtgaag  480
ttcaaaaga  cttctg  496



<210> 6074
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> NP_033209
<400> 6074

Met Arg Ser Ile Arg Lys Arg Trp Thr Ile Cys Thr Ile Ser Leu Leu 
  1               5                  10                  15
Leu Ile Phe Tyr Lys Thr Lys Glu Ile Ala Arg Thr Glu Glu His Gln 
             20                  25                  30
Glu Thr Gln Leu Ile Gly Asp Gly Glu Leu Cys Leu Ser Arg Ser Leu 
         35                  40                  45
Val Asn Ser Ser Asp Lys Ile Ile Arg Lys Ala Gly Ser Thr Ile Phe 
     50                  55                  60
Gln His Ser Val Gln Gly Trp Lys Ile Asn Ser Ser Leu Val Leu Glu 
 65                  70                  75                  80
Ile Arg Lys Asn Ile Leu Arg Phe Leu Asp Ala Glu Arg Asp Val Ser 
                 85                  90                  95
Val Val Lys Ser Ser Phe Lys Pro Gly Asp Val Ile His Tyr Val Leu 
             100                105                110
Asp Arg Arg Arg Thr Leu Asn Ile Ser His Asn Leu His Ser Leu Leu 
         115                120                125
Pro Glu Val Ser Pro Met Lys Asn Arg Arg Phe Lys Thr Cys Ala Val 
     130                135                140
Val Gly Asn Ser Gly Ile Leu Leu Asp Ser Gly Cys Gly Lys Glu Ile 
 145                150                155                160
Asp Ser His Asn Phe Val Ile Arg Cys Asn Leu Ala Pro Val Val Glu 
                 165                170                175
Phe Ala Ala Asp Val Gly Thr Lys Ser Asp Phe Ile Thr Met Asn Pro 
             180                185                190
Ser Val Val Gln Arg Ala Phe Gly Gly Phe Arg Asn Glu Ser Asp Arg 
         195                200                205
Glu Lys Phe Val His Arg Leu Ser Met Leu Asn Asp Ser Val Leu Trp 
     210                215                220
Ile Pro Ala Phe Met Val Lys Gly Gly Glu Lys His Val Glu Trp Val 
 225                230                235                240
Asn Ala Leu Ile Leu Lys Asn Lys Leu Gln Val Arg Thr Ala Tyr Pro 
                 245                250                255
Ser Leu Arg Leu Ile His Ala Val Arg Gly Tyr Trp Leu Thr Asn Lys 
             260                265                270
Val Pro Ile Lys Arg Pro Ser Thr Gly Leu Leu Met Tyr Thr Leu Ala 
         275                280                285
Thr Arg Phe Cys Asp Glu Ile His Leu Tyr Gly Phe Trp Pro Phe Pro 
     290                295                300
Lys Asp Leu Asn Gly Lys Ala Val Lys Tyr His Tyr Tyr Asp Asp Leu 
 305                310                315                320
Lys Tyr Arg Tyr Phe Ser Asn Ala Ser Pro His Arg Met Pro Leu Glu 
                 325                330                335
Phe Lys Thr Leu Asn Val Leu His Asn Arg Gly Ala Leu Lys Leu Thr 
             340                345                350
Thr Gly Lys Cys Met Lys Gln 
         355



<210> 6075
<211> 381
<212> DNA
<213> Homo sapiens
<308> AA833803
<400> 6075

ttttttttt  aaaaaaagg  attaattta  tttacaatt  tacaaatga  aaaacaata  60
tacccggtt  ctatacaca  acaataaga  aacagtgtt  aacagaatg  acttgaact  120
gacagaata  acctcatct  tcagttcca  aaattctat  agaaatact  agtagcaat  180
attctgtgc  gcaatgcta  ctctgtaaa  tcttttttt  tcctgctat  tacatttga  240
acacttgtg  ttttgccta  acaaagaaa  ggtttttat  aaaaggtgc  acttaaatg  300
gaaacacaa  gcctggagc  acaatctga  aactgtaat  cgaatacat  gctagcttg  360
agcctttac  tttcttctt  a  381



<210> 6076
<211> 359
<212> PRT
<213> Homo sapiens
<308> NP_005659
<400> 6076

Met Arg Ser Ile Arg Lys Arg Trp Thr Ile Cys Thr Ile Ser Leu Leu 
  1               5                  10                  15
Leu Ile Phe Tyr Lys Thr Lys Glu Ile Ala Arg Thr Glu Glu His Gln 
             20                  25                  30
Glu Thr Gln Leu Ile Gly Asp Gly Glu Leu Ser Leu Ser Arg Ser Leu 
         35                  40                  45
Val Asn Ser Ser Asp Lys Ile Ile Arg Lys Ala Gly Ser Ser Ile Phe 
     50                  55                  60
Gln His Asn Val Glu Gly Trp Lys Ile Asn Ser Ser Leu Val Leu Glu 
 65                  70                  75                  80
Ile Arg Lys Asn Ile Leu Arg Phe Leu Asp Ala Glu Arg Asp Val Ser 
                 85                  90                  95
Val Val Lys Ser Ser Phe Lys Pro Gly Asp Val Ile His Tyr Val Leu 
             100                105                110
Asp Arg Arg Arg Thr Leu Asn Ile Ser His Asp Leu His Ser Leu Leu 
         115                120                125
Pro Glu Val Ser Pro Met Lys Asn Arg Arg Phe Lys Thr Cys Ala Val 
     130                135                140
Val Gly Asn Ser Gly Ile Leu Leu Asp Ser Glu Cys Gly Lys Glu Ile 
 145                150                155                160
Asp Ser His Asn Phe Val Ile Arg Cys Asn Leu Ala Pro Val Val Glu 
                 165                170                175
Phe Ala Ala Asp Val Gly Thr Lys Ser Asp Phe Ile Thr Met Asn Pro 
             180                185                190
Ser Val Val Gln Arg Ala Phe Gly Gly Phe Arg Asn Glu Ser Asp Arg 
         195                200                205
Glu Lys Phe Val His Arg Leu Ser Met Leu Asn Asp Ser Val Leu Trp 
     210                215                220
Ile Pro Ala Phe Met Val Lys Gly Gly Glu Lys His Val Glu Trp Val 
 225                230                235                240
Asn Ala Leu Ile Leu Lys Asn Lys Leu Lys Val Arg Thr Ala Tyr Pro 
                 245                250                255
Ser Leu Arg Leu Ile His Ala Val Arg Gly Tyr Trp Leu Thr Asn Lys 
             260                265                270
Val Pro Ile Lys Arg Pro Ser Thr Gly Leu Leu Met Tyr Thr Leu Ala 
         275                280                285
Thr Arg Phe Cys Asp Glu Ile His Leu Tyr Gly Phe Trp Pro Phe Pro 
     290                295                300
Lys Asp Leu Asn Gly Lys Ala Val Lys Tyr His Tyr Tyr Asp Asp Leu 
 305                310                315                320
Lys Tyr Arg Tyr Phe Ser Asn Ala Ser Pro His Arg Met Pro Leu Glu 
                 325                330                335
Phe Lys Thr Leu Asn Val Leu His Asn Arg Gly Ala Leu Lys Leu Thr 
             340                345                350
Thr Gly Lys Cys Val Lys Gln 
         355



<210> 6077
<211> 409
<212> DNA
<213> Rattus norvegicus
<308> AA893664
<400> 6077

aaaaacaat  cattttatt  ggttttaaa  ctagttaca  aattgaaag  caattaggt  60
ctactctgt  cagggactg  gcctgggta  gctcacact  caatactgt  ctaagccca  120
tgtgtagat  gagacattc  gcatgtaga  actaaaaaa  aaactgtag  attccttta  180
ggaagattg  aaagggtgt  tcacaagat  acattcatc  actttgaat  attccaact  240
gaagatatt  tacactcta  agttgtgac  ggcaaacat  ttacttaaa  atgcacaca  300
aaaggtaca  aaaaatcca  atattctaa  gataaatga  cttaaaaaa  cacctatgt  360
tcagctttt  taacatgag  agataaaga  tataattta  aaacacaca  409



<210> 6078
<211> 6106
<212> DNA
<213> Homo sapiens
<308> D38521
<400> 6078

cgccgagtc  gacttgcag  tggcccaga  caaatgcaa  ctgggccgg  ccgtgcagc  60
ccaagagct  tggcccggg  gcctcttct  gaccaggaa  ctctccaca  atattcgac  120
ttatgggag  aaatttagc  aagaagatc  tgttctttt  attaagtta  tgtatgagc  180
ggtatcaat  ccaaaactg  aaatcagca  gatgcaggg  tttgcccgc  ttttgatca  240
cttgttaaa  aaaaaggaa  ttctttcaa  agctgattt  gagttaccc  ggagaccac  300
ttatgacat  gtagaaaga  tattatatt  caagacaga  cacctagga  taaattggt  360
tcctaattc  gtagaaaat  ttctcaaaa  actcgtgaa  agctgccga  catattttc  420
agcagatgc  accgctgag  tgctagaag  atggcgacc  ttaatgtgc  cttttgatg  480
aaccatgca  aaggccatc  cttattttg  aatatttct  cctacctcc  ttcctccag  540
acttcatca  aaaggtttt  aactttggt  tgatgaatt  attggcctt  gggtttcag  600
gcaaaatct  ccacaatgg  aggggcaac  agtaaatct  tttgctcga  tggctacag  660
taatatagg  tacatagat  gggatccat  tgtaccaaa  atatttaca  gaattctga  720
aagcttgaa  ctcccagtg  gaagcagtc  agtgttagt  ccaagattt  taacaaatg  780
ttatgatat  ggacatgct  taatatgga  caccgccat  atgggtgga  caagtaagc  840
agtgcaaaa  cacttagct  gtttgttta  cagcatcac  tctttttac  atccttcaa  900
taatgggcg  tggctgaac  agttaatga  actacttca  cggttgcca  acagtgttg  960
tagaagatt  catcgtgaa  gatacaaga  gccctcttg  ttaactcct  tgcctgata  1020
ccacaagct  actgatcaa  atgttacag  ctttgtaca  tgcattatt  agcctgtcc  1080
cttggctat  tttagcaaa  ccggtagtc  agaagcagc  caggctttg  agaatcttg  1140
actcatgag  cctgaattg  taatacccc  tgtacttga  agaacatat  ctgcattag  1200
gacattaac  gaacctcac  agctcacag  tactttaag  tgtgtaatt  gagtagccc  1260
cagtttggt  tcaggaggc  gatggtttc  tgaaggtcc  acacatatg  tacctctgt  1320
gatgagagc  ttgcctggg  tggatccaa  tgactttag  aaatgcatg  tcacattcc  1380
gttcatagc  acattttct  ctctggtgc  tttagtaga  tgttcatct  tactacaag  1440
aagaaatga  ctcacagaa  tggaacgag  actttgttc  gccacagct  aatttgagg  1500
tttcgtctt  cagtttatg  acagatgtt  tggacttat  gaaagtagc  cattggagc  1560
aacaagaga  gagacagaa  ctgagaaaa  gacacactt  gagagtttg  tcgaattag  1620
tctgtcttc  acgtttagt  caatcctca  ccaatgttc  aaagaaata  ttatggtgg  1680
ccttcagaa  gtttttaat  tttctactt  acatatatt  gaaacaaga  tagcaggtc  1740
catggtggc  gacatgtgc  gcgctgctg  aaagtgctg  ccagaagaa  ctttgaagc  1800
ctttgttcc  cactgctgc  gtgttataa  tcagcttac  atgaatgat  atgtattaa  1860
tgatgaaga  ctagacaag  aattactat  gaatcttca  cttttgtct  agattactc  1920
agtggatgg  aggaagttg  ttctttata  ggagcagct  gtaaagatt  tccaaagaa  1980
cctacattt  acctgtaag  agggttaca  tctgtcttg  aaccttttg  atcatcttc  2040
ccgttctac  acacttatc  accctacag  atactgcag  gtgccaggt  gctttgaca  2100
gcctccttc  gaatacttt  ctatcaagg  ctggggcaa  cccggggac  tgtggaatc  2160
gggaatcca  tggcatgtt  cttcttcag  agaagtgtc  tttgccttt  atcttttgg  2220
ctcctttct  cagcctgag  tcgtcaaac  ccagcattg  ggggatgga  aacttgaaa  2280
gtctagaga  gatattcta  agagtctga  tatagtgca  aactgttta  ttggctctg  2340
aaacctcct  cctccgttg  aaggagagc  agttactaa  ttagtacca  gtatggtgt  2400
cttggaaga  acaaagttg  atactggac  tgaatatga  ctgtctcga  agaaccacc  2460
agaagtaat  gctacagtt  taaggaaac  tcttaacca  atacttgat  attcagaag  2520
tgatactaa  tcattgttt  ttattataa  gattattgg  gacctttta  aattccaag  2580
atctcacaa  catgaattt  actcccgat  gaaaagctt  aacttagta  agaaatcaa  2640
ggaaaatcg  ctccatggg  aaaaacaac  tatcagagc  ctgttgatt  atagagtaa  2700
gttacagca  gagctacgg  cactaactg  tgagggttg  gaatacaaa  agatacatc  2760
agatatgat  agagatctt  ttcgtttat  tacaagttc  tacagtcag  tgagaaata  2820
ggctcagca  acatttttt  ctgccttgg  agcatataa  ttctgttgc  gagatatca  2880
tcccttggt  ttggagttc  taaggcctg  tagacaagg  gttacacag  aacaattca  2940
gggtgcctt  tactgtctc  ttggaaatc  cagtggtgt  tgcttggca  accttcatg  3000
ttgggactg  attgtacag  cgtggccag  gattgtttc  tcagggctt  gccaagcaa  3060
gtccctgga  aagccatca  tagtgagat  gtttgatga  cttgcagaa  agattcata  3120
gcagtatga  acaattggc  tggacttca  aattccaaa  tcatgtgtt  aaatagcgg  3180
attacttca  cagtcaaaa  acccctcta  caaccagat  ttgcttagc  cagaaaaaa  3240
taaggaagg  attaaacgc  aacaagaaa  gaatgccga  gccctaagg  actatgaaa  3300
tttggtaga  accttgcta  atggtgtgg  gcaaagaaa  ctgccctgg  aatttgaac  3360
tataggcat  gggcttctg  ctctactgc  gagagatga  cgagtgttg  ctcttcgtg  3420
catacggtt  tttgttgag  atctcaacc  tgatgcaat  gtagttcga  agatggcta  3480
ctcagctgt  gctggtatc  ttaaacagc  aaaaagaac  cacaaaaag  tgaccatta  3540
cccctgtga  atcagtgga  gccctaaac  cacccaaat  attgctggt  ataggcctg  3600
taatcattg  ttgcattat  acagcaaaa  tataccaag  actaaaaaa  aatgggagt  3660
aagttgctt  gtggaaaaa  ctcactggg  atactacac  tggccaaag  atatggttg  3720
ttatgctgg  gtggaagag  agcctaagc  tggcagaag  agggaggat  tgacagagg  3780
agaacagat  atatttgat  atttttctg  tcctaaatt  gttgagcag  taattactt  3840
tctatcatt  gaagacaga  aaggaaaag  taagtttaa  ccacgacgt  tttgtctct  3900
taagggtat  ttcaggaat  ttgatgatg  cttcctgcc  gttctgaag  cccatttag  3960
acatttggt  gcagattca  atgaaagca  ccagcgatg  gttgcagaa  ttatagctg  4020
tttaatcag  ggttctaag  actggacat  tgaaaaggt  gagaagctt  gggagcttc  4080
gtgccctct  cttagaaca  cactgtcca  tattaccgt  gaaacttat  atgactggg  4140
agcttgtat  gcaacatcc  gtgaaagca  agatccccg  aaacttcac  ggctttttg  4200
actgctgtt  gaatcacca  tgagtggtg  aggaggatc  tttgtagat  catgtcgac  4260
ttatgtact  caaggtggc  ttgcccagc  agaatggag  gtgcctgaa  tattgcaca  4320
actactgaa  tacttggaa  ccaaactca  ccaggttta  aaaaatgtc  gagaaagaa  4380
aggaagtgt  ctgacctac  tattcatga  agatgtatc  ttgccaaat  ccacaccaa  4440
catatcgcc  catgtccct  agtttactg  tcgaattct  gagaaattg  aacctctca  4500
ggatgtgga  gaagaaatt  agaaccatg  tatggaaga  aatggaatt  gtgaagaag  4560
tgagcgaac  cagggcatt  aactcttga  aaccatatt  aaatggctg  tggcaagtg  4620
aggaagatc  ttttctaca  cagttacag  acaacttca  cttctacct  tgtttttca  4680
gattgcccc  gtggaaaat  acaatagct  cgatgaact  aaaagagat  caaagttat  4740
tttatcatt  atgtctcag  ggttgcttt  ccctcatca  gtgcctttg  tacttcagg  4800
gctaaaaca  acagcaaga  gcagttctt  gcatgcacg  tacacagta  tgacctacc  4860
ccagaccat  gtattttat  acctcttta  tttcctaaa  aatgaagat  cagttaaag  4920
tatcaggtg  ctggttata  gtcttttgg  ggacgaaca  ctggaggtt  gagaaatgg  4980
tgctactac  ttaagcggt  tgctacagt  taactttct  accatggac  gtcctatgc  5040
gattcattt  gagcaactt  gcaaaacaa  actacctaa  aaaagaaag  gagaccctg  5100
ttctgtagg  gataccatt  cttctgcag  gttggtcaa  cgccatgct  gggtgctag  5160
acttggtgc  tgtgttctt  ctagtcctt  cgatgttcc  acctggatg  cccagctcc  5220
catgaatct  agtgcacat  taaatgatc  tcagcctat  gagatgact  taaaaaaaa  5280
cttatccaa  ttccgaagg  ctcaccatg  caactggca  gaacataaa  agcaattca  5340
tgatgacca  ctgcttgtt  tcaccgatc  tcttgtgtc  ccatgctat  atgcataga  5400
agatgacta  tcctcactt  aggctcttt  catcaaaaa  tccacaccc  caggtacca  5460
ctgtggtgg  tctctgcaa  ttttaaaac  gcctctgct  agctctcat  attttggtg  5520
tttctgtgt  agatctcgt  agtctgcat  ccacagctt  tcagttgcc  tttgatttc  5580
caacttgtc  ggaagtgtt  ccagaatac  gatcacttt  tttttttga  gcatctgac  5640
aagtcacaa  gtctcagac  agaaataat  acccagtat  atcatggca  ccaagacca  5700
agtctcaga  ctcattaag  aacagttta  ttggaatgg  gaataccca  ctgtaatac  5760
ggtcctgtc  tttcattca  ctcaaatta  tttgaattc  tcccaaatg  ctgctggat  5820
taggtggta  taggggctg  gggccataa  tctgaagcc  tgagaacct  gggtctgga  5880
agccatgaa  agggaagga  aagagggca  gtcctgaac  taaccaatg  cctgatgga  5940
tgctcgacc  agacacaga  gtgaagtct  tgtctgtgc  cttcccaca  actggagtt  6000
ttggtgctg  atagagcca  ttgctaaaa  attgggggt  tggtgaaga  atctgattg  6060
tgtgtgtat  caatgtgtg  ttttaaaaa  aaacagcaa  aacaat  6106



<210> 6079
<211> 485
<212> DNA
<213> Rattus norvegicus
<308> AA893667
<400> 6079

aaagacaga  ccacaacgc  tttcaaagg  gaaaaagaa  atgcccttt  cctcctggg  60
cgagggtga  gggaaggat  gaggtcaat  cattcttct  tcagactcg  tctcatcca  120
tgggtgtcc  cggggagga  cgttttctg  aagccagtg  agaagggtg  cctgttctc  180
ctggtgtcc  aagctcagc  ctgtccagt  tccgaggag  ctcctccca  gaacagggg  240
tggctgtcc  tgtgtgggt  ggaagaagt  agtcctgct  catctcgat  agcgctgcg  300
tgccgctcc  tctcaccgt  gcagcagcg  gtaccccct  agggcgggc  ggtcagctg  360
ggcatctgg  tcagtccag  caggcccat  agaagccaa  catcatgtc  gcaatttgg  420
cctgcactc  ggagctggg  tccaataac  ctgcctcac  catccttgc  tgtcatcag  480
ttttg  485



<210> 6080
<211> 227
<212> PRT
<213> Rattus norvegicus
<308> AAK69754
<400> 6080

Met Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro 
  1               5                  10                  15
Gly Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro 
             20                  25                  30
His Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser 
         35                  40                  45
Arg Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala 
     50                  55                  60
Gly Gly Val Pro Phe Ser Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly 
 65                  70                  75                  80
Asp Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Thr Ser Asp Ser Thr 
                 85                  90                  95
Tyr Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg 
             100                105                110
Asp Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu 
         115                120                125
Pro Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys 
     130                135                140
Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His 
 145                150                155                160
Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val 
                 165                170                175
Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu 
             180                185                190
Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys 
         195                200                205
Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His 
     210                215                220
Pro Ala Asp 
 225



<210> 6082
<211> 227
<212> PRT
<213> Homo sapiens
<308> AF378524
<400> 6082

Met Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro 
  1               5                  10                  15
Gly Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro 
             20                  25                  30
His Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser 
         35                  40                  45
Arg Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala 
     50                  55                  60
Gly Gly Val Pro Phe Gly Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly 
 65                  70                  75                  80
Asp Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Ala Ser Asp Ser Thr 
                 85                  90                  95
Tyr Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg 
             100                105                110
Asp Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu 
         115                120                125
Pro Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys 
     130                135                140
Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His 
 145                150                155                160
Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val 
                 165                170                175
Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu 
             180                185                190
Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys 
         195                200                205
Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His 
     210                215                220
Pro Ala Asp 
 225



<210> 6083
<211> 485
<212> DNA
<213> Rattus norvegicus
<308> AA893667
<400> 6083

aaagacaga  ccacaacgc  tttcaaagg  gaaaaagaa  atgcccttt  cctcctggg  60
cgagggtga  gggaaggat  gaggtcaat  cattcttct  tcagactcg  tctcatcca  120
tgggtgtcc  cggggagga  cgttttctg  aagccagtg  agaagggtg  cctgttctc  180
ctggtgtcc  aagctcagc  ctgtccagt  tccgaggag  ctcctccca  gaacagggg  240
tggctgtcc  tgtgtgggt  ggaagaagt  agtcctgct  catctcgat  agcgctgcg  300
tgccgctcc  tctcaccgt  gcagcagcg  gtaccccct  agggcgggc  ggtcagctg  360
ggcatctgg  tcagtccag  caggcccat  agaagccaa  catcatgtc  gcaatttgg  420
cctgcactc  ggagctggg  tccaataac  ctgcctcac  catccttgc  tgtcatcag  480
ttttg  485



<210> 6084
<211> 227
<212> PRT
<213> Rattus norvegicus
<308> AAK69754
<400> 6084

Met Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro 
  1               5                  10                  15
Gly Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro 
             20                  25                  30
His Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser 
         35                  40                  45
Arg Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala 
     50                  55                  60
Gly Gly Val Pro Phe Ser Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly 
 65                  70                  75                  80
Asp Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Thr Ser Asp Ser Thr 
                 85                  90                  95
Tyr Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg 
             100                105                110
Asp Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu 
         115                120                125
Pro Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys 
     130                135                140
Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His 
 145                150                155                160
Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val 
                 165                170                175
Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu 
             180                185                190
Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys 
         195                200                205
Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His 
     210                215                220
Pro Ala Asp 
 225



<210> 6086
<211> 227
<212> PRT
<213> Homo sapiens
<308> AF378524
<400> 6086

Met Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro 
  1               5                  10                  15
Gly Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro 
             20                  25                  30
His Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser 
         35                  40                  45
Arg Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala 
     50                  55                  60
Gly Gly Val Pro Phe Gly Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly 
 65                  70                  75                  80
Asp Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Ala Ser Asp Ser Thr 
                 85                  90                  95
Tyr Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg 
             100                105                110
Asp Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu 
         115                120                125
Pro Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys 
     130                135                140
Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His 
 145                150                155                160
Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val 
                 165                170                175
Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu 
             180                185                190
Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys 
         195                200                205
Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His 
     210                215                220
Pro Ala Asp 
 225



<210> 6087
<211> 485
<212> DNA
<213> Rattus norvegicus
<308> AA893667
<400> 6087

aaagacaga  ccacaacgc  tttcaaagg  gaaaaagaa  atgcccttt  cctcctggg  60
cgagggtga  gggaaggat  gaggtcaat  cattcttct  tcagactcg  tctcatcca  120
tgggtgtcc  cggggagga  cgttttctg  aagccagtg  agaagggtg  cctgttctc  180
ctggtgtcc  aagctcagc  ctgtccagt  tccgaggag  ctcctccca  gaacagggg  240
tggctgtcc  tgtgtgggt  ggaagaagt  agtcctgct  catctcgat  agcgctgcg  300
tgccgctcc  tctcaccgt  gcagcagcg  gtaccccct  agggcgggc  ggtcagctg  360
ggcatctgg  tcagtccag  caggcccat  agaagccaa  catcatgtc  gcaatttgg  420
cctgcactc  ggagctggg  tccaataac  ctgcctcac  catccttgc  tgtcatcag  480
ttttg  485



<210> 6088
<211> 227
<212> PRT
<213> Rattus norvegicus
<308> AAK69754
<400> 6088

Met Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro 
  1               5                  10                  15
Gly Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro 
             20                  25                  30
His Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser 
         35                  40                  45
Arg Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala 
     50                  55                  60
Gly Gly Val Pro Phe Ser Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly 
 65                  70                  75                  80
Asp Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Thr Ser Asp Ser Thr 
                 85                  90                  95
Tyr Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg 
             100                105                110
Asp Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu 
         115                120                125
Pro Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys 
     130                135                140
Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His 
 145                150                155                160
Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val 
                 165                170                175
Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu 
             180                185                190
Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys 
         195                200                205
Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His 
     210                215                220
Pro Ala Asp 
 225



<210> 6090
<211> 227
<212> PRT
<213> Homo sapiens
<308> AF378524
<400> 6090

Met Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro 
  1               5                  10                  15
Gly Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro 
             20                  25                  30
His Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser 
         35                  40                  45
Arg Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala 
     50                  55                  60
Gly Gly Val Pro Phe Gly Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly 
 65                  70                  75                  80
Asp Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Ala Ser Asp Ser Thr 
                 85                  90                  95
Tyr Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg 
             100                105                110
Asp Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu 
         115                120                125
Pro Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys 
     130                135                140
Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His 
 145                150                155                160
Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val 
                 165                170                175
Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu 
             180                185                190
Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys 
         195                200                205
Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His 
     210                215                220
Pro Ala Asp 
 225



<210> 6091
<211> 485
<212> DNA
<213> Rattus norvegicus
<308> AA893667
<400> 6091

aaagacaga  ccacaacgc  tttcaaagg  gaaaaagaa  atgcccttt  cctcctggg  60
cgagggtga  gggaaggat  gaggtcaat  cattcttct  tcagactcg  tctcatcca  120
tgggtgtcc  cggggagga  cgttttctg  aagccagtg  agaagggtg  cctgttctc  180
ctggtgtcc  aagctcagc  ctgtccagt  tccgaggag  ctcctccca  gaacagggg  240
tggctgtcc  tgtgtgggt  ggaagaagt  agtcctgct  catctcgat  agcgctgcg  300
tgccgctcc  tctcaccgt  gcagcagcg  gtaccccct  agggcgggc  ggtcagctg  360
ggcatctgg  tcagtccag  caggcccat  agaagccaa  catcatgtc  gcaatttgg  420
cctgcactc  ggagctggg  tccaataac  ctgcctcac  catccttgc  tgtcatcag  480
ttttg  485



<210> 6092
<211> 227
<212> PRT
<213> Rattus norvegicus
<308> AAK69754
<400> 6092

Met Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro 
  1               5                  10                  15
Gly Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro 
             20                  25                  30
His Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser 
         35                  40                  45
Arg Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala 
     50                  55                  60
Gly Gly Val Pro Phe Ser Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly 
 65                  70                  75                  80
Asp Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Thr Ser Asp Ser Thr 
                 85                  90                  95
Tyr Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg 
             100                105                110
Asp Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu 
         115                120                125
Pro Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys 
     130                135                140
Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His 
 145                150                155                160
Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val 
                 165                170                175
Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu 
             180                185                190
Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys 
         195                200                205
Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His 
     210                215                220
Pro Ala Asp 
 225



<210> 6094
<211> 227
<212> PRT
<213> Homo sapiens
<308> AF378524
<400> 6094

Met Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro 
  1               5                  10                  15
Gly Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro 
             20                  25                  30
His Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser 
         35                  40                  45
Arg Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala 
     50                  55                  60
Gly Gly Val Pro Phe Gly Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly 
 65                  70                  75                  80
Asp Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Ala Ser Asp Ser Thr 
                 85                  90                  95
Tyr Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg 
             100                105                110
Asp Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu 
         115                120                125
Pro Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys 
     130                135                140
Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His 
 145                150                155                160
Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val 
                 165                170                175
Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu 
             180                185                190
Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys 
         195                200                205
Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His 
     210                215                220
Pro Ala Asp 
 225



<210> 6095
<211> 485
<212> DNA
<213> Rattus norvegicus
<308> AA893667
<400> 6095

aaagacaga  ccacaacgc  tttcaaagg  gaaaaagaa  atgcccttt  cctcctggg  60
cgagggtga  gggaaggat  gaggtcaat  cattcttct  tcagactcg  tctcatcca  120
tgggtgtcc  cggggagga  cgttttctg  aagccagtg  agaagggtg  cctgttctc  180
ctggtgtcc  aagctcagc  ctgtccagt  tccgaggag  ctcctccca  gaacagggg  240
tggctgtcc  tgtgtgggt  ggaagaagt  agtcctgct  catctcgat  agcgctgcg  300
tgccgctcc  tctcaccgt  gcagcagcg  gtaccccct  agggcgggc  ggtcagctg  360
ggcatctgg  tcagtccag  caggcccat  agaagccaa  catcatgtc  gcaatttgg  420
cctgcactc  ggagctggg  tccaataac  ctgcctcac  catccttgc  tgtcatcag  480
ttttg  485



<210> 6096
<211> 227
<212> PRT
<213> Rattus norvegicus
<308> AAK69754
<400> 6096

Met Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro 
  1               5                  10                  15
Gly Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro 
             20                  25                  30
His Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser 
         35                  40                  45
Arg Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala 
     50                  55                  60
Gly Gly Val Pro Phe Ser Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly 
 65                  70                  75                  80
Asp Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Thr Ser Asp Ser Thr 
                 85                  90                  95
Tyr Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg 
             100                105                110
Asp Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu 
         115                120                125
Pro Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys 
     130                135                140
Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His 
 145                150                155                160
Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val 
                 165                170                175
Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu 
             180                185                190
Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys 
         195                200                205
Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His 
     210                215                220
Pro Ala Asp 
 225



<210> 6098
<211> 227
<212> PRT
<213> Homo sapiens
<308> AF378524
<400> 6098

Met Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro 
  1               5                  10                  15
Gly Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro 
             20                  25                  30
His Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser 
         35                  40                  45
Arg Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala 
     50                  55                  60
Gly Gly Val Pro Phe Gly Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly 
 65                  70                  75                  80
Asp Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Ala Ser Asp Ser Thr 
                 85                  90                  95
Tyr Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg 
             100                105                110
Asp Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu 
         115                120                125
Pro Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys 
     130                135                140
Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His 
 145                150                155                160
Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val 
                 165                170                175
Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu 
             180                185                190
Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys 
         195                200                205
Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His 
     210                215                220
Pro Ala Asp 
 225



<210> 6099
<211> 485
<212> DNA
<213> Rattus norvegicus
<308> AA893667
<400> 6099

aaagacaga  ccacaacgc  tttcaaagg  gaaaaagaa  atgcccttt  cctcctggg  60
cgagggtga  gggaaggat  gaggtcaat  cattcttct  tcagactcg  tctcatcca  120
tgggtgtcc  cggggagga  cgttttctg  aagccagtg  agaagggtg  cctgttctc  180
ctggtgtcc  aagctcagc  ctgtccagt  tccgaggag  ctcctccca  gaacagggg  240
tggctgtcc  tgtgtgggt  ggaagaagt  agtcctgct  catctcgat  agcgctgcg  300
tgccgctcc  tctcaccgt  gcagcagcg  gtaccccct  agggcgggc  ggtcagctg  360
ggcatctgg  tcagtccag  caggcccat  agaagccaa  catcatgtc  gcaatttgg  420
cctgcactc  ggagctggg  tccaataac  ctgcctcac  catccttgc  tgtcatcag  480
ttttg  485



<210> 6100
<211> 227
<212> PRT
<213> Rattus norvegicus
<308> AAK69754
<400> 6100

Met Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro 
  1               5                  10                  15
Gly Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro 
             20                  25                  30
His Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser 
         35                  40                  45
Arg Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala 
     50                  55                  60
Gly Gly Val Pro Phe Ser Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly 
 65                  70                  75                  80
Asp Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Thr Ser Asp Ser Thr 
                 85                  90                  95
Tyr Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg 
             100                105                110
Asp Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu 
         115                120                125
Pro Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys 
     130                135                140
Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His 
 145                150                155                160
Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val 
                 165                170                175
Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu 
             180                185                190
Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys 
         195                200                205
Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His 
     210                215                220
Pro Ala Asp 
 225



<210> 6102
<211> 227
<212> PRT
<213> Homo sapiens
<308> AF378524
<400> 6102

Met Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro 
  1               5                  10                  15
Gly Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro 
             20                  25                  30
His Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser 
         35                  40                  45
Arg Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala 
     50                  55                  60
Gly Gly Val Pro Phe Gly Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly 
 65                  70                  75                  80
Asp Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Ala Ser Asp Ser Thr 
                 85                  90                  95
Tyr Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg 
             100                105                110
Asp Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu 
         115                120                125
Pro Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys 
     130                135                140
Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His 
 145                150                155                160
Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val 
                 165                170                175
Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu 
             180                185                190
Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys 
         195                200                205
Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His 
     210                215                220
Pro Ala Asp 
 225



<210> 6103
<211> 461
<212> DNA
<213> Rattus norvegicus
<308> AA893670
<400> 6103

ggtagaaaa  tcattgtat  gaataatca  aatatttct  tatagacag  tctctacag  60
tccagtgct  tagggaaat  cttccagaa  accagttga  ttcagaata  aagctttgt  120
cagaccact  tccacttaa  aaatattga  acctatact  ctgagactc  gactttatt  180
agattttca  atataatag  gcatagttt  cattgcatc  aaggagcaa  cagggatgg  240
agcatgtca  tttgtaaca  ctgtcactg  ggcttttcg  ttctggttt  cagaaacct  300
atcctcagt  aaatctagt  atgctttta  gaaatgctt  aggtcactc  aagcttggc  360
attaacatt  ggcatgaac  agggtaaaa  cagcacaat  gagaacaga  acaacctca  420
aggccataa  cacatacag  aaaggatga  aaaagagaa  g  461



<210> 6104
<211> 497
<212> DNA
<213> Rattus norvegicus
<308> AA893683
<400> 6104

gagaaacta  ggtatttta  ttgaaggaa  ccaagtgaa  gccaagtgt  aaaggtgga  60
tgctgggag  caaggctgt  agtgcactg  cggcgtcag  gcctcgtac  gtctctggg  120
ggccagttc  accatttct  ggagggact  atcatcctc  cttccttct  cacattcta  180
agcccgagt  tccaaatta  tatttgctg  ttttccatc  accgtgaca  tgaggacag  240
gtcatcttt  acactgaca  agtcttctc  aaatatgtc  tggagcatg  cctcaagcc  300
cttgctgta  acgtgcatc  ctagcttct  agagacctt  tgcactgca  ctttcctta  360
ttttggatt  gactgaact  ccaatatca  ggtggtcac  gtgtctgca  acatgtcgt  420
agaggggtt  gccagccac  ccaggacca  catgcccgg  tcctgcacc  cggtgatgc  480
tttgaatac  ttcaaag  497



<210> 6105
<211> 684
<212> PRT
<213> Rattus norvegicus
<308> NP_061283
<400> 6105

Met Ser Ala Ile Pro Ala Glu Glu Ser Asp Gln Leu Leu Ile Arg Pro 
  1               5                  10                  15
Leu Gly Ala Gly Gln Glu Val Gly Arg Ser Cys Ile Ile Leu Glu Phe 
             20                  25                  30
Lys Gly Arg Lys Ile Met Leu Asp Cys Gly Ile His Pro Gly Leu Glu 
         35                  40                  45
Gly Met Asp Ala Leu Pro Tyr Ile Asp Leu Ile Asp Pro Ala Glu Ile 
     50                  55                  60
Asp Leu Leu Leu Ile Ser His Phe His Leu Asp His Cys Gly Ala Leu 
 65                  70                  75                  80
Pro Trp Phe Leu Gln Lys Thr Ser Phe Lys Gly Arg Thr Phe Met Thr 
                 85                  90                  95
His Ala Thr Lys Ala Ile Tyr Arg Trp Leu Leu Ser Asp Tyr Val Lys 
             100                105                110
Val Ser Asn Ile Ser Ala Asp Asp Met Leu Tyr Thr Glu Thr Asp Leu 
         115                120                125
Glu Glu Ser Met Asp Lys Ile Glu Thr Ile Asn Phe His Glu Val Lys 
     130                135                140
Glu Val Ala Gly Ile Lys Phe Trp Cys Tyr His Ala Gly His Val Leu 
 145                150                155                160
Gly Ala Ala Met Phe Met Ile Glu Ile Ala Gly Val Lys Leu Leu Tyr 
                 165                170                175
Thr Gly Asp Phe Ser Arg Gln Glu Asp Arg His Leu Met Ala Ala Glu 
             180                185                190
Ile Pro Asn Ile Lys Pro Asp Ile Leu Ile Ile Glu Ser Thr Tyr Gly 
         195                200                205
Thr His Ile His Glu Lys Arg Glu Glu Arg Glu Ala Arg Phe Trp His 
     210                215                220
Thr Val His Asp Ile Val Asn Arg Gly Gly Arg Gly Leu Ile Pro Val 
 225                230                235                240
Phe Ala Leu Gly Arg Ala Gln Glu Leu Leu Leu Ile Leu Asp Glu Tyr 
                 245                250                255
Trp Gln Asn His Pro Glu Leu His Asp Ile Pro Ile Tyr Tyr Ala Ser 
             260                265                270
Ser Leu Ala Lys Lys Cys Met Ala Val Tyr Gln Thr Tyr Val Asn Ala 
         275                280                285
Met Asn Asp Lys Ile Arg Lys Gln Ile Asn Ile Asn Asn Pro Phe Val 
     290                295                300
Phe Lys His Ile Ser Asn Leu Lys Ser Met Asp His Phe Asp Asp Ile 
 305                310                315                320
Gly Pro Ser Val Val Met Ala Ser Pro Gly Met Ile Gln Asn Gly Leu 
                 325                330                335
Ser Arg Glu Leu Phe Glu Ser Trp Cys Thr Asp Lys Arg Asn Gly Val 
             340                345                350
Ile Ile Ala Gly Tyr Cys Val Glu Gly Thr Leu Ala Lys His Ile Met 
         355                360                365
Ser Glu Pro Glu Glu Ile Thr Thr Met Ser Gly Gln Lys Leu Pro Leu 
     370                375                380
Lys Met Ser Val Asp Tyr Ile Ser Phe Ser Ala His Thr Asp Tyr Gln 
 385                390                395                400
Gln Thr Ser Glu Phe Ile Arg Ala Leu Lys Pro Pro His Val Ile Leu 
                 405                410                415
Val His Gly Glu Gln Asn Glu Met Ala Arg Leu Lys Ala Ala Leu Ile 
             420                425                430
Arg Glu Tyr Glu Asp Asn Asp Glu Val His Ile Glu Val His Asn Pro 
         435                440                445
Arg Asn Thr Glu Ala Val Thr Leu Asn Phe Arg Gly Glu Lys Leu Ala 
     450                455                460
Lys Val Met Gly Phe Leu Ala Asp Lys Lys Pro Glu Gln Gly Gln Arg 
 465                470                475                480
Val Ser Gly Ile Leu Val Lys Arg Asn Phe Asn Tyr His Ile Leu Ser 
                 485                490                495
Pro Cys Asp Leu Ser Asn Tyr Thr Asp Leu Ala Met Ser Thr Val Lys 
             500                505                510
Gln Thr Gln Ala Ile Pro Tyr Thr Gly Pro Phe Tyr Leu Leu Tyr Tyr 
         515                520                525
Gln Leu Gln Lys Leu Thr Gly Asp Val Glu Glu Leu Asp Ile Gln Glu 
     530                535                540
Lys Pro Ala Leu Lys Val Phe Lys Ser Ile Thr Val Val Gln Glu Pro 
 545                550                555                560
Gly Met Val Gly Ser Glu Trp Leu Ala Asn Pro Ser Asn Asp Met Tyr 
                 565                570                575
Ala Asp Thr Val Thr Thr Val Ile Leu Glu Val Gln Ser Asn Pro Lys 
             580                585                590
Ile Arg Lys Gly Ala Val Gln Lys Val Ser Lys Lys Leu Glu Met His 
         595                600                605
Val Tyr Ser Lys Arg Leu Glu Val Met Leu Gln Asp Ile Phe Gly Glu 
     610                615                620
Asp Cys Val Ser Val Lys Asp Asp Ser Val Leu Ser Val Thr Val Asp 
 625                630                635                640
Gly Lys Thr Ala Asn Ile Asn Leu Glu Thr Arg Ala Val Glu Cys Glu 
                 645                650                655
Glu Gly Ser Glu Asp Asp Glu Ser Leu Arg Glu Met Val Glu Leu Ala 
             660                665                670
Ala Gln Arg Leu Tyr Glu Ala Leu Thr Pro Val His 
         675                680



<210> 6106
<211> 2286
<212> DNA
<213> Homo sapiens
<308> NM_016207
<400> 6106

gttcctcac  cccgcttcg  cctcacact  tcgggatgt  tgcgattcc  gctgaggag  60
gcgaccagc  gctgatccg  ccccttgga  ctgggcaag  agtaggaag  tcatgtatt  120
ttctcgagt  caaaggaag  aaaataatg  tcgactgtg  gatccaccc  ggcctagaa  180
gaatggatg  tcttcctta  attgattta  ttgacccag  tgagattga  ctcctatta  240
ttagtcatt  ccatttgga  cactgtgga  ctctgccct  gtttctaca  aagacaagt  300
tcaaaggaa  aacatttat  actcatgcc  caaaagcta  ttatagatg  cttctttct  360
attatgtca  agttagtaa  atatcagca  acgacatgc  gtataccga  acagatttg  420
aagaaagca  ggacaaaat  gaaactatc  actttcatg  agttaagga  gttgcggga  480
tcaagtttt  gtgttacca  gcaggtcac  tcctaggag  cgccatgtt  atgattgag  540
tcgcaggcg  gaagctttt  tacactggt  atttctcaa  acaagaaga  aggcactta  600
tggcagctg  aattcctaa  attaagcct  atattctta  cattgaatc  acttatggg  660
cccatatcc  tgagaaacg  gaagagcga  aagcaagat  ctgtaacac  gtccacgat  720
ttgtaaaca  aggaggcag  ggtctcatt  ctgtctttg  tcttggaag  gctcaggag  780
tgctcttga  tctagatga  tactggcag  atcacccag  actacatga  attccaata  840
actatgcat  atctttggc  aagaagtgt  tggcagtgt  ccagacata  gtaaatgcc  900
tgaatgaca  aatccgcaa  cagatcaac  tcaataatc  ctttgtttt  aaacacatt  960
gtaacctca  gagcatgga  cattttgat  acattggtc  cagtgttgt  atggcctcc  1020
caggcatga  gcaaagtgg  ttatccaga  aattatttg  aagctggtg  actgataag  1080
ggaatggtg  cattatagc  ggatactgt  tagaaggga  acttgccaa  cacatcatg  1140
ctgaacctg  agaaatcac  actatgtct  gacagaagt  accactgaa  atgtctgtt  1200
attacattt  tttctcagc  cacacggat  accagcaaa  cagtgaatt  attcgtgct  1260
tgaaaccgc  tcatgtgat  ttagtccat  gagaacaga  tgaaatggc  agattgaaa  1320
cagcactga  tcgagaata  gaagataac  atgaagttc  catagaggt  cataatcct  1380
ggaatacag  agcagtgac  ttaaacttc  gaggagaaa  actagccaa  gttatggga  1440
ttttagcag  caaaaaacc  gaacaaggc  agcgggtct  aggaatact  gttaaaaga  1500
actttaatt  tcacatact  tctccttgc  acctgtcca  ttatactga  ctggccatg  1560
gcacggtga  gcagaccca  gccattcca  atactggtc  ctttaattt  ctctgttac  1620
agctgcaga  attgacagg  gatgtggaa  aattagaaa  tcaagaaaa  cctgctctg  1680
aagtgttca  aaatattac  gtaatacaa  aaccaggca  ggtggtatt  gaatggctg  1740
caaaccctt  taatgatat  tatgcagat  cagtaacaa  tgtgatatt  gaagttcag  1800
caaatccca  aataagaaa  ggtgcagta  agaaggttt  taaaaaatt  gaaatgcac  1860
tttacagca  gaggttgga  atcatgctc  aggacatat  tggagaaga  tgtgtaagt  1920
taaaggatg  ctctattct  agcgtcaca  tggacggga  aactgccaa  cttaacttg  1980
agacacgga  tgtagaatg  gaagaggga  gtgaagacg  tgaatccct  cgagaaatg  2040
tggagctgg  tgcacagag  ctgtacgag  ccctgacgc  agttcactg  gactgtgcc  2100
gtatatgaa  tttgaaaaa  tacttgact  tacttttgt  acctaaaat  aaatgcatt  2160
gtttctctg  gaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2220
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2280
aaaaaa  2286



<210> 6107
<211> 684
<212> PRT
<213> Homo sapiens
<308> Q9UKF6
<400> 6107

Met Ser Ala Ile Pro Ala Glu Glu Ser Asp Gln Leu Leu Ile Arg Pro 
  1               5                  10                  15
Leu Gly Ala Gly Gln Glu Val Gly Arg Ser Cys Ile Ile Leu Glu Phe 
             20                  25                  30
Lys Gly Arg Lys Ile Met Leu Asp Cys Gly Ile His Pro Gly Leu Glu 
         35                  40                  45
Gly Met Asp Ala Leu Pro Tyr Ile Asp Leu Ile Asp Pro Ala Glu Ile 
     50                  55                  60
Asp Leu Leu Leu Ile Ser His Phe His Leu Asp His Cys Gly Ala Leu 
 65                  70                  75                  80
Pro Trp Phe Leu Gln Lys Thr Ser Phe Lys Gly Arg Thr Phe Met Thr 
                 85                  90                  95
His Ala Thr Lys Ala Ile Tyr Arg Trp Leu Leu Ser Asp Tyr Val Lys 
             100                105                110
Val Ser Asn Ile Ser Ala Asp Asp Met Leu Tyr Thr Glu Thr Asp Leu 
         115                120                125
Glu Glu Ser Met Asp Lys Ile Glu Thr Ile Asn Phe His Glu Val Lys 
     130                135                140
Glu Val Ala Gly Ile Lys Phe Trp Cys Tyr His Ala Gly His Val Leu 
 145                150                155                160
Gly Ala Ala Met Phe Met Ile Glu Ile Ala Gly Val Lys Leu Leu Tyr 
                 165                170                175
Thr Gly Asp Phe Ser Arg Gln Glu Asp Arg His Leu Met Ala Ala Glu 
             180                185                190
Ile Pro Asn Ile Lys Pro Asp Ile Leu Ile Ile Glu Ser Thr Tyr Gly 
         195                200                205
Thr His Ile His Glu Lys Arg Glu Glu Arg Glu Ala Arg Phe Cys Asn 
     210                215                220
Thr Val His Asp Ile Val Asn Arg Gly Gly Arg Gly Leu Ile Pro Val 
 225                230                235                240
Phe Ala Leu Gly Arg Ala Gln Glu Leu Leu Leu Ile Leu Asp Glu Tyr 
                 245                250                255
Trp Gln Asn His Pro Glu Leu His Asp Ile Pro Ile Tyr Tyr Ala Ser 
             260                265                270
Ser Leu Ala Lys Lys Cys Met Ala Val Tyr Gln Thr Tyr Val Asn Ala 
         275                280                285
Met Asn Asp Lys Ile Arg Lys Gln Ile Asn Ile Asn Asn Pro Phe Val 
     290                295                300
Phe Lys His Ile Ser Asn Leu Lys Ser Met Asp His Phe Asp Asp Ile 
 305                310                315                320
Gly Pro Ser Val Val Met Ala Ser Pro Gly Met Met Gln Ser Gly Leu 
                 325                330                335
Ser Arg Glu Leu Phe Glu Ser Trp Cys Thr Asp Lys Arg Asn Gly Val 
             340                345                350
Ile Ile Ala Gly Tyr Cys Val Glu Gly Thr Leu Ala Lys His Ile Met 
         355                360                365
Ser Glu Pro Glu Glu Ile Thr Thr Met Ser Gly Gln Lys Leu Pro Leu 
     370                375                380
Lys Met Ser Val Asp Tyr Ile Ser Phe Ser Ala His Thr Asp Tyr Gln 
 385                390                395                400
Gln Thr Ser Glu Phe Ile Arg Ala Leu Lys Pro Pro His Val Ile Leu 
                 405                410                415
Val His Gly Glu Gln Asn Glu Met Ala Arg Leu Lys Ala Ala Leu Ile 
             420                425                430
Arg Glu Tyr Glu Asp Asn Asp Glu Val His Ile Glu Val His Asn Pro 
         435                440                445
Arg Asn Thr Glu Ala Val Thr Leu Asn Phe Arg Gly Glu Lys Leu Ala 
     450                455                460
Lys Val Met Gly Phe Leu Ala Asp Lys Lys Pro Glu Gln Gly Gln Arg 
 465                470                475                480
Val Ser Gly Ile Leu Val Lys Arg Asn Phe Asn Tyr His Ile Leu Ser 
                 485                490                495
Pro Cys Asp Leu Ser Asn Tyr Thr Asp Leu Ala Met Ser Thr Val Lys 
             500                505                510
Gln Thr Gln Ala Ile Pro Tyr Thr Gly Pro Phe Asn Leu Leu Cys Tyr 
         515                520                525
Gln Leu Gln Lys Leu Thr Gly Asp Val Glu Glu Leu Glu Ile Gln Glu 
     530                535                540
Lys Pro Ala Leu Lys Val Phe Lys Asn Ile Thr Val Ile Gln Glu Pro 
 545                550                555                560
Gly Met Val Val Leu Glu Trp Leu Ala Asn Pro Ser Asn Asp Met Tyr 
                 565                570                575
Ala Asp Thr Val Thr Thr Val Ile Leu Glu Val Gln Ser Asn Pro Lys 
             580                585                590
Ile Arg Lys Gly Ala Val Gln Lys Val Ser Lys Lys Leu Glu Met His 
         595                600                605
Val Tyr Ser Lys Arg Leu Glu Ile Met Leu Gln Asp Ile Phe Gly Glu 
     610                615                620
Asp Cys Val Ser Val Lys Asp Asp Ser Ile Leu Ser Val Thr Val Asp 
 625                630                635                640
Gly Lys Thr Ala Asn Leu Asn Leu Glu Thr Arg Thr Val Glu Cys Glu 
                 645                650                655
Glu Gly Ser Glu Asp Asp Glu Ser Leu Arg Glu Met Val Glu Leu Ala 
             660                665                670
Ala Gln Arg Leu Tyr Glu Ala Leu Thr Pro Val His 
         675                680



<210> 6108
<211> 492
<212> DNA
<213> Rattus norvegicus
<308> AA893690
<400> 6108

aataaggtg  tctgaggaa  caggaaatt  acagagagg  gcgaataag  aatgcttct  60
aagccctgc  cagtatttc  tcagtcatc  tctggtaac  ggatcttgc  gggatcaaa  120
tagttggat  ccatgatgg  gaggccgtt  agttctcgg  atttcacaa  tctctcagc  180
tcccggcgg  cccactctt  catcctaga  tttgacttt  ttttcaaat  aataattgt  240
cttacctac  tgtttggga  tactcgccc  gtctgttaa  ctgcaccag  aagtgctat  300
tataaaggt  aaaaaatgt  tggatgttg  caatttcct  tgggttcac  taatctata  360
caccctata  atttaagat  ctcaactag  ggttaggta  ttatatatt  ggtcttttc  420
aatacacaa  cctcctaat  tgcccagta  agaggaaat  gcaataata  acaccttat  480
attctgagt  tt  492



<210> 6109
<211> 133
<212> PRT
<213> Rattus norvegicus
<308> NP_062308
<400> 6109

Met Arg Gly Leu Pro Ala Ala Arg Val Arg Trp Glu Ser Ser Arg Ala 
  1               5                  10                  15
Val Ile Ala Pro Ser Gly Val Glu Lys Lys Arg Gln Arg Glu Pro Thr 
             20                  25                  30
Met Gln Trp Gln Glu Asp Pro Glu Pro Glu Asp Glu Asn Val Tyr Ala 
         35                  40                  45
Lys Asn Pro Asp Phe His Gly Tyr Asp Ser Asp Pro Val Val Asp Val 
     50                  55                  60
Trp Asn Met Arg Ala Val Phe Phe Phe Gly Phe Ser Ile Val Leu Val 
 65                  70                  75                  80
Phe Gly Thr Thr Phe Val Ala Tyr Val Pro Asp Tyr Arg Met Gln Glu 
                 85                  90                  95
Trp Ala Arg Arg Glu Ala Glu Arg Leu Val Lys Tyr Arg Glu Val Asn 
             100                105                110
Gly Leu Pro Ile Met Glu Ser Asn Tyr Phe Asp Pro Ser Lys Ile Gln 
         115                120                125
Leu Pro Glu Asp Asp 
     130



<210> 6110
<211> 386
<212> DNA
<213> Homo sapiens
<308> AA286860
<400> 6110

ttcagactt  cagcccctt  aattaggtg  tctgagaag  ggtcagaat  gcaggcagg  60
ggtggggaa  gcggtgctt  ttgagcccc  cttagcaac  ggtcactca  cctctggca  120
ctggatctt  ctggggtcg  agcagttgg  ttccatgat  ggaaggcca  tggctctcg  180
tatttcaca  gcctctcag  ttcgcggcg  gaccactct  tcatcccat  ccacgctct  240
ggacaccct  tgcacctgt  gtcaggcag  taggccaca  aggtgctgc  aaggaccag  300
atgatggag  cgccaaaga  gaagacaag  cgcatgttc  agacgtcca  aacggggtc  360
ttgtcataa  catgggagt  tgggtt  386



<210> 6111
<211> 153
<212> PRT
<213> Homo sapiens
<308> AAH10665
<400> 6111

Met Ala Ala Gly Leu Phe Gly Leu Ser Ala Arg Arg Leu Leu Ala Ala 
  1               5                  10                  15
Ala Ala Thr Arg Gly Leu Pro Ala Ala Arg Val Arg Trp Glu Ser Ser 
             20                  25                  30
Phe Ser Arg Thr Val Val Ala Pro Ser Ala Val Ala Gly Lys Arg Pro 
         35                  40                  45
Pro Glu Pro Thr Thr Pro Trp Gln Glu Asp Pro Glu Pro Glu Asp Glu 
     50                  55                  60
Asn Leu Tyr Glu Lys Asn Pro Asp Ser His Gly Tyr Asp Lys Asp Pro 
 65                  70                  75                  80
Val Leu Asp Val Trp Asn Met Arg Leu Val Phe Phe Phe Gly Val Ser 
                 85                  90                  95
Ile Ile Leu Val Leu Gly Ser Thr Phe Val Ala Tyr Leu Pro Asp Tyr 
             100                105                110
Arg Met Lys Glu Trp Ser Arg Arg Glu Ala Glu Arg Leu Val Lys Tyr 
         115                120                125
Arg Glu Ala Asn Gly Leu Pro Ile Met Glu Ser Asn Cys Phe Asp Pro 
     130                135                140
Ser Lys Ile Gln Leu Pro Glu Asp Glu 
 145                150



<210> 6112
<211> 472
<212> DNA
<213> Rattus norvegicus
<308> AA893717
<400> 6112

ccacataat  ttccaaata  atgtcttac  gataagggt  agtatgagt  tcagaaaac  60
tcccaggga  ggaagccat  ttagacact  gaaaatgct  accaaaaaa  caatgctta  120
atacacatg  ctggaaaaa  ctcaccacc  aaagtgcaa  gacagaagc  actaacgtt  180
tcgctgtat  aaaatagac  atcttctga  ctattagct  gctttttaa  taggctcca  240
tggacaaag  acaaagggt  agtcgtcag  atgaatcag  ctttaaacc  atctggctt  300
gaccccaat  aactgcaaa  aaagtccag  ttgaggctg  ctagagact  cacgccacg  360
gggatcata  cctctagca  tttctacaa  tcagactta  cccagttag  agtgagtat  420
ctcagatca  tgcctcggc  tacccgccg  acaaggctc  cggacatgt  tc  472



<210> 6113
<211> 628
<212> PRT
<213> Rattus norvegicus
<308> AAH10715
<400> 6113

Met Asp Thr Thr Met Val Asn Leu Trp Thr Leu Phe Glu Gln Leu Val 
  1               5                  10                  15
Arg Arg Met Glu Ile Ile Asn Glu Gly Asn Glu Ser Ile Glu Phe Ile 
             20                  25                  30
Gln Val Val Lys Asp Phe Glu Asp Phe Arg Lys Lys Tyr Gln Arg Thr 
         35                  40                  45
Asn Gln Glu Leu Glu Lys Phe Lys Asp Leu Leu Leu Lys Ala Glu Thr 
     50                  55                  60
Gly Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val 
 65                  70                  75                  80
Asp Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Glu Cys Ala Lys 
                 85                  90                  95
Leu Glu Gln Gln Ile Gln Leu Ile Arg Asp Ile Leu Met Cys Asp Thr 
             100                105                110
Ser Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe 
         115                120                125
Leu Asn Arg Gly Gln Ala Ser Ser Gly His Ala Gly Asn Asn Arg Leu 
     130                135                140
Ser Thr Ile Asp Glu Ser Gly Ser Ile Leu Ser Asp Ile Ser Phe Asp 
 145                150                155                160
Lys Thr Asp Glu Ser Leu Asp Trp Asp Ser Ser Leu Val Lys Asn Phe 
                 165                170                175
Lys Met Lys Lys Arg Glu Lys Arg Arg Ser Asn Ser Arg Gln Phe Ile 
             180                185                190
Asp Gly Pro Pro Gly Pro Val Lys Lys Thr Cys Ser Ile Gly Ser Thr 
         195                200                205
Val Asp Gln Ala Asn Glu Ser Ile Val Ala Lys Thr Thr Val Thr Val 
     210                215                220
Pro Ser Asp Gly Gly Pro Ile Glu Ala Val Ser Thr Ile Glu Thr Leu 
 225                230                235                240
Pro Ser Trp Thr Arg Ser Arg Gly Lys Ser Gly Pro Leu Gln Pro Val 
                 245                250                255
Asn Ser Asp Ser Ala Leu Asn Ser Arg Pro Leu Glu Pro Arg Thr Asp 
             260                265                270
Thr Asp Asn Leu Gly Thr Pro Gln Asn Thr Gly Gly Met Arg Leu His 
         275                280                285
Asp Phe Val Ser Lys Thr Val Ile Lys Pro Glu Ser Cys Val Pro Cys 
     290                295                300
Gly Lys Arg Ile Lys Phe Gly Lys Leu Ser Leu Lys Cys Arg Asp Cys 
 305                310                315                320
Arg Leu Val Ser His Pro Glu Cys Arg Asp Arg Cys Pro Leu Pro Cys 
                 325                330                335
Ile Pro Pro Leu Val Gly Thr Pro Val Lys Ile Gly Glu Gly Met Leu 
             340                345                350
Ala Asp Phe Val Ser Gln Ala Ser Pro Met Ile Pro Ala Ile Val Val 
         355                360                365
Ser Cys Val Asn Glu Ile Glu Gln Arg Gly Leu Thr Glu Ala Gly Leu 
     370                375                380
Tyr Arg Ile Ser Gly Cys Asp Arg Thr Val Lys Glu Leu Lys Glu Lys 
 385                390                395                400
Phe Leu Lys Val Lys Thr Val Pro Leu Leu Ser Lys Val Asp Asp Ile 
                 405                410                415
His Val Ile Cys Ser Leu Leu Lys Asp Phe Leu Arg Asn Leu Lys Glu 
             420                425                430
Pro Leu Leu Thr Phe Trp Leu Ser Lys Ala Phe Met Glu Ala Ala Glu 
         435                440                445
Ile Thr Asp Glu Asp Asn Ser Thr Ala Ala Met Tyr Gln Ala Val Ser 
     450                455                460
Glu Leu Pro Gln Ala Asn Arg Asp Thr Leu Ala Phe Leu Met Ile His 
 465                470                475                480
Leu Gln Arg Val Ser Gln Ser Pro Asp Thr Lys Met Asp Ile Ala Asn 
                 485                490                495
Leu Ala Lys Val Phe Gly Pro Thr Ile Val Ala His Thr Val Pro Asn 
             500                505                510
Pro Asp Pro Val Thr Met Phe Gln Asp Ile Lys Arg Gln Leu Lys Val 
         515                520                525
Val Glu Arg Leu Leu Ser Leu Pro Leu Glu Tyr Trp Asn Gln Phe Met 
     530                535                540
Met Val Asp Gln Glu Asn Ile Asp Ser Gln Arg Gly Asn Gly Asn Ser 
 545                550                555                560
Thr Pro Arg Thr Pro Asp Val Lys Val Ser Leu Leu Gly Pro Val Thr 
                 565                570                575
Thr Pro Glu Phe Gln Leu Val Lys Thr Pro Leu Ser Ser Ser Leu Ser 
             580                585                590
Gln Arg Leu Tyr Asn Leu Ser Lys Ser Thr Pro Arg Phe Gly Asn Lys 
         595                600                605
Ser Lys Ser Ala Thr Asn Leu Gly Gln Gln Gly Lys Phe Phe Pro Ala 
     610                615                620
Pro Tyr Leu Lys 
 625



<210> 6114
<211> 3237
<212> DNA
<213> Homo sapiens
<308> AL136794
<400> 6114

gcgaagtga  gggtggccc  ggtggggcc  ggctgactg  atgtatctc  tagctatgg  60
ctaaataat  catgggggg  aataaacaa  tattcatga  ggtgaaaat  tgacccagc  120
ggaaaatta  aactatttt  aattgacgt  gaataggat  agtcatgga  tttaagtga  180
ttactgaag  ttatactac  ggtagatag  agagctaaa  aaagatgga  actatgatg  240
tgaatgtgc  gaatctgtt  gagcagctt  tgcgccggg  ggagattct  agtgaagga  300
atgaagtcc  atttatcca  ttggcgaag  actttgagg  tttccgtaa  aagtggcag  360
ggactgacc  tgagctggg  aaatacaag  atcttttga  gaaagcaga  actgagcga  420
gtgctctgg  tgttaagct  aagcatgca  gtaatcagg  ggatgtaga  atcaaacgg  480
gacagagag  tgaggctga  tgcgaaaag  tggaacgac  gattcagct  attcgagag  540
tgctcatgt  tgacacatc  ggcagcatt  aactaagcg  ggagcaaaa  tcagctctg  600
cttttctca  cagaggcca  ccatccagc  gcaatgctg  gaacaaaag  ctatcaacc  660
ttgatgaat  tggttccat  ttatcagat  tcagctttg  caagactga  gaatcactg  720
attgggact  ttctttggt  aagactttc  aactgaaga  gagagaaaa  aggcgctct  780
ctagccgac  gtttgttga  ggtccccct  gacctgtaa  gaaaactcg  tccattggc  840
ctgcagtag  ccaggggaa  gaatccata  ttgcaaaaa  tacagtgac  gttcccaat  900
atggcgggc  catcgaagc  gtgtccact  ttgagactg  gccatattg  accaggagc  960
gaaggaaaa  aggtacttt  caaccttgg  acagtgact  caccctgaa  agcaggcag  1020
tggagccaa  aactgagac  gacagtgtg  gcacgccac  gagtaatgg  gggatgcgc  1080
tgcatgact  tgtttctaa  acggttatt  aacctgaat  ctgtgttcc  tgtggaaag  1140
ggataaaat  tggcaaatt  tctctgaag  gtcgagact  tcgtgtggt  tctcatcca  1200
aatgtcggg  ccgctgtcc  cttccctgc  ttcctaccc  gataggaac  cctgtcaag  1260
ttggagagg  aatgctggc  gactttgtg  cccagactt  tccaatgat  ccctccatt  1320
ttgtgcatt  tgtaaatga  attgagcaa  gaggtctga  tgagacagg  ctgtatagg  1380
tctctggct  tgaccgcac  gtaaaagag  tgaaagaga  attcctcag  gtgaaaact  1440
tacccctcc  cagcaaagt  gatgatatc  atgctatct  tagccttct  aaagacttt  1500
ttcgaaacc  caaagaacc  cttctgacc  ttcgcctta  cagagcctt  atggaagca  1560
cagaaatca  agatgaaga  aacagcata  ctgccatgt  ccaagctgt  ggtgaactg  1620
cccaggcca  cagggacac  ttagctttc  tcatgattc  cttgcagag  gtggctcag  1680
gtccacata  taaaatgga  gttgccaat  tggctaaag  ctttggccc  acaatagtg  1740
cccatgctg  gcccaatcc  gacccagtg  caatgttac  ggacatcaa  cgtcaaccc  1800
aggtggttg  gcgcctgct  tccttgcct  tggagtatt  gagtcagtt  atgatggtg  1860
agcaagaga  cattgaccc  ctacatgtc  ttgaaaact  aaatgcctt  tcaacacca  1920
agacaccag  tattaaagt  agtttactg  gacctgtga  cactcctga  catcagctt  1980
tcaagactc  ttcatctag  tccctgtca  agagagtcc  ttccaccct  accaagaac  2040
ctcctagat  tgggagcaa  agcaagtct  ccactaacc  aggacgaca  ggcaacttt  2100
ttgcttctc  aatgctcaa  tgaagtcac  tctgcctgt  acttcccag  attgactga  2160
tataagaaa  gacacatct  tactctgct  tgcagcctc  tgtactcat  actactttt  2220
gcattctcc  ggcttttac  caagtttaa  tgtgcatga  ggttttatt  aaactatat  2280
tatctcccc  tccttctcc  caagtcaca  aatatcagc  ctttgtgct  gtcattgtt  2340
ggagctttt  gatgagaca  ctttccagg  gtagaaggg  tagtatgga  ttggttgtg  2400
ttctttttg  ggaaggggg  tattgttcc  ttggcttaa  gccaaatgc  gctcataga  2460
tgatctttc  ctagtttca  ttagaactg  tttccgtga  acaatgaca  aaaccctac  2520
tatctgata  gattagctt  tctcagggt  ggaagtggg  gggcagggc  aagaaagga  2580
tagaccaga  gatttagga  gcctccttc  aagaaccag  agttctcat  ccccattat  2640
aactgagct  taatatgga  ctttcataa  aatgggatg  attgaggac  gaactagtg  2700
tgggagtat  cgtagcttt  atttggatg  ttaggtctt  aatagtgtt  agtggcaca  2760
ccttgtaaa  gtgaaagta  aactcgtat  tatctctga  gtgccgctg  ctgaacttt  2820
ggttcattt  gggtcaaag  cagtttttc  tttaaaatt  aattcattc  gatgcttgg  2880
ccccatacc  ccaaccttg  ccagtggag  ccaacttct  aaggtcaat  tatcatcct  2940
tggcatccc  actaacaat  aagagtagg  tataaggga  gattgtcaa  attttgtgg  3000
aagaaaagc  acagtcatt  tttctttgc  ctttggatg  tgaaatttt  cccatggaa  3060
atagccaca  ctagataga  gtgagcttt  tcttctgtt  aaattattc  taatgtctg  3120
aaaaacgat  ttcttctgt  gaatgtttg  cttcgtatt  acccttatc  gtaaaacac  3180
tatttggga  aatatttgg  aaaaaagta  atagctttt  caaaatgaa  aaaaaaa  3237



<210> 6115
<211> 632
<212> PRT
<213> Homo sapiens
<308> CAB66728
<400> 6115

Met Asp Thr Met Met Leu Asn Val Arg Asn Leu Phe Glu Gln Leu Val 
  1               5                  10                  15
Arg Arg Val Glu Ile Leu Ser Glu Gly Asn Glu Val Gln Phe Ile Gln 
             20                  25                  30
Leu Ala Lys Asp Phe Glu Asp Phe Arg Lys Lys Trp Gln Arg Thr Asp 
         35                  40                  45
His Glu Leu Gly Lys Tyr Lys Asp Leu Leu Met Lys Ala Glu Thr Glu 
     50                  55                  60
Arg Ser Ala Leu Asp Val Lys Leu Lys His Ala Arg Asn Gln Val Asp 
 65                  70                  75                  80
Val Glu Ile Lys Arg Arg Gln Arg Ala Glu Ala Asp Cys Glu Lys Leu 
                 85                  90                  95
Glu Arg Gln Ile Gln Leu Ile Arg Glu Met Leu Met Cys Asp Thr Ser 
             100                105                110
Gly Ser Ile Gln Leu Ser Glu Glu Gln Lys Ser Ala Leu Ala Phe Leu 
         115                120                125
Asn Arg Gly Gln Pro Ser Ser Ser Asn Ala Gly Asn Lys Arg Leu Ser 
     130                135                140
Thr Ile Asp Glu Ser Gly Ser Ile Leu Ser Asp Ile Ser Phe Asp Lys 
 145                150                155                160
Thr Asp Glu Ser Leu Asp Trp Asp Ser Ser Leu Val Lys Thr Phe Lys 
                 165                170                175
Leu Lys Lys Arg Glu Lys Arg Arg Ser Thr Ser Arg Gln Phe Val Asp 
             180                185                190
Gly Pro Pro Gly Pro Val Lys Lys Thr Arg Ser Ile Gly Ser Ala Val 
         195                200                205
Asp Gln Gly Asn Glu Ser Ile Val Ala Lys Thr Thr Val Thr Val Pro 
     210                215                220
Asn Asp Gly Gly Pro Ile Glu Ala Val Ser Thr Ile Glu Thr Val Pro 
 225                230                235                240
Tyr Trp Thr Arg Ser Arg Arg Lys Thr Gly Thr Leu Gln Pro Trp Asn 
                 245                250                255
Ser Asp Ser Thr Leu Asn Ser Arg Gln Leu Glu Pro Arg Thr Glu Thr 
             260                265                270
Asp Ser Val Gly Thr Pro Gln Ser Asn Gly Gly Met Arg Leu His Asp 
         275                280                285
Phe Val Ser Lys Thr Val Ile Lys Pro Glu Ser Cys Val Pro Cys Gly 
     290                295                300
Lys Arg Ile Lys Phe Gly Lys Leu Ser Leu Lys Cys Arg Asp Cys Arg 
 305                310                315                320
Val Val Ser His Pro Glu Cys Arg Asp Arg Cys Pro Leu Pro Cys Ile 
                 325                330                335
Pro Thr Leu Ile Gly Thr Pro Val Lys Ile Gly Glu Gly Met Leu Ala 
             340                345                350
Asp Phe Val Ser Gln Thr Ser Pro Met Ile Pro Ser Ile Val Val His 
         355                360                365
Cys Val Asn Glu Ile Glu Gln Arg Gly Leu Thr Glu Thr Gly Leu Tyr 
     370                375                380
Arg Ile Ser Gly Cys Asp Arg Thr Val Lys Glu Leu Lys Glu Lys Phe 
 385                390                395                400
Leu Arg Val Lys Thr Val Pro Leu Leu Ser Lys Val Asp Asp Ile His 
                 405                410                415
Ala Ile Cys Ser Leu Leu Lys Asp Phe Leu Arg Asn Leu Lys Glu Pro 
             420                425                430
Leu Leu Thr Phe Arg Leu Asn Arg Ala Phe Met Glu Ala Ala Glu Ile 
         435                440                445
Thr Asp Glu Asp Asn Ser Ile Ala Ala Met Tyr Gln Ala Val Gly Glu 
     450                455                460
Leu Pro Gln Ala Asn Arg Asp Thr Leu Ala Phe Leu Met Ile His Leu 
 465                470                475                480
Gln Arg Val Ala Gln Ser Pro His Thr Lys Met Asp Val Ala Asn Leu 
                 485                490                495
Ala Lys Val Phe Gly Pro Thr Ile Val Ala His Ala Val Pro Asn Pro 
             500                505                510
Asp Pro Val Thr Met Leu Gln Asp Ile Lys Arg Gln Pro Lys Val Val 
         515                520                525
Glu Arg Leu Leu Ser Leu Pro Leu Glu Tyr Trp Ser Gln Phe Met Met 
     530                535                540
Val Glu Gln Glu Asn Ile Asp Pro Leu His Val Ile Glu Asn Ser Asn 
 545                550                555                560
Ala Phe Ser Thr Pro Gln Thr Pro Asp Ile Lys Val Ser Leu Leu Gly 
                 565                570                575
Pro Val Thr Thr Pro Glu His Gln Leu Leu Lys Thr Pro Ser Ser Ser 
             580                585                590
Ser Leu Ser Gln Arg Val Arg Ser Thr Leu Thr Lys Asn Thr Pro Arg 
         595                600                605
Phe Gly Ser Lys Ser Lys Ser Ala Thr Asn Leu Gly Arg Gln Gly Asn 
     610                615                620
Phe Phe Ala Ser Pro Met Leu Lys 
 625                630



<210> 6116
<211> 444
<212> DNA
<213> Rattus norvegicus
<308> AA893733
<400> 6116

ggatgttga  ggcaaactc  ttattagga  aaagaaaaa  gggatgcac  tggtctgct  60
aaaagggag  accccatgg  tcgaaccca  ggagttctg  gcaaaggta  ctggctgca  120
agaaaaaac  ggtacttgg  cttatcacc  gcccccacc  tcaccctgc  gtcattctt  180
ctcttcctc  tcctccaaa  gtggtcgat  ccgcttgaa  aagccagcc  tccacatgg  240
caaaactag  agggtcagc  gcagcagac  gcccagcac  cctaccagc  cccaccaga  300
agggatgtc  ctctcctcc  aggcccgaa  cagatgtgt  tgcaccaga  cttgcccgc  360
gggcaagct  accaccggc  ccgagtacg  tagggagga  acgttgaac  aggcgtgcg  420
ctgcagcac  aactgctcc  gggg  444



<210> 6117
<211> 3333
<212> DNA
<213> Homo sapiens
<308> M34480
<400> 6117

attcctgcc  gggaggttg  ggaagaagg  agatggcca  agctttgtg  ccactgcaa  60
ccctctggc  tctggagtg  gtgctgctg  tcttgggag  ttgtgctgc  cctccagcc  120
gggccttga  cctggaccc  gtgcagctc  ccttctatg  aggccccaa  ggcagccag  180
ttggatttt  actggactt  cacaaggac  gccatggga  agtggccat  gtggtgggc  240
ccccgcgga  cctgggccc  agccaggag  agacgggcg  cgtgttcct  tgcccctgg  300
gggccgagg  cggccagtg  ccctcgctg  tctttgacc  ccgtgatga  acccgaaat  360
taggctccc  aactttaca  accttcaag  cccgccaag  actgggggc  tcggtcgtc  420
gctggagcg  cgtcattgt  gcctgcgcc  cctggcagc  ctggaacgt  ctagaaaag  480
ctgaggagg  tgagaagac  cccgtaggt  gctgctttt  ggctcagcc  gagagcggc  540
gccgcgccg  gtactcccc  tgtcgcggg  acaccctga  ccgcattta  gtggaaaat  600
attttagct  ggacaagcg  tactgtgaa  cgggcttca  ctcggtggt  actcaggcc  660
gagagctgg  gcttggggc  cctggcggc  attatttct  aggtctcct  gcccaggct  720
cagttgcgg  tattttctc  agttaccgc  caggcatcc  tttgtggca  gtgtcctcc  780
agagcctct  ctttgactc  agcaaccca  agtacttcg  cggctactg  gggtactcg  840
tggccgtgg  cgagttcga  ggggatctc  acactacag  atatgtcgt  ggtgccccc  900
cttggagct  gaccctggg  gcggtggaa  ttttggatt  ctactacca  aggctgcat  960
ggctgcgcg  agagcagat  gcgtcgtat  ttgggcatt  agtcgctgt  actgacgtc  1020
acggggatg  gaggcatga  ctgctggtg  gcgctccac  gtatatgga  agccgggca  1080
accgaaaac  ggccgaagt  gggcgtgtg  atttgttcc  gcagccgcg  ggcccccac  1140
cgctgggtg  ccccagcct  ctgctgact  gcacacagc  ctatgggcg  ttcggctct  1200
ccatcgcac  cctgggcga  ctcgaccgg  atggctaca  tgacattgc  gtggctgcc  1260
cctacgggg  tcccagtgg  cggggccaa  tgctggtgt  cctgggtca  agtgagggg  1320
tgaggtcac  tccctccca  gtcctggac  gccccttcc  cacaggctc  gcctttggc  1380
tctcccttc  aggtgccgt  gacatcgat  acaacggat  cccagacct  atcgtggga  1440
cttacgggg  caaccaggt  gctgtgtac  gagctcagc  agtggtgaa  gcctctgtc  1500
agctactgg  gcaagattc  ctgaatcct  ctgtgaaga  ctgtgtcct  cctcagacc  1560
agacacccg  gagctgctt  aacatccag  tgtgtgttg  agccactgg  cacaacatt  1620
ctcagaagc  atccctaaa  gccgagctg  agctggacc  gcagaagcc  cgccagggc  1680
ggcgggtgc  gctgctggg  tctcaacag  caggcacca  cctggacct  gatctgggc  1740
gaaagcaca  ccccatctg  cacaccacc  tggccttcc  tcgagatga  gcagacttc  1800
gggacaagc  gagccccat  gtgctcagc  tcaatgtgt  cctaccgcc  acggaggct  1860
gaatggccc  tgctgtcgt  ctgcatgga  acacccatg  gcaggagca  acacgaatc  1920
tcctggact  tggggaaga  gacgtatgt  tgccccagc  tcagctcac  gccagcgtg  1980
cgggctccc  gctcctagt  ggggcagat  atgtcctgg  gctgcagat  gacgcagcc  2040
acgagggcg  gggggccta  gaagcagag  tggcggtgc  cctgcccca  ggcgcccac  2100
acatgcggg  cctaagcaa  gtcgagggc  ttgagagac  catctgtaa  cagaagaag  2160
agaatgaga  cagggtggt  ctgtgtgag  tgggcaacc  catgaagaa  aacgcccag  2220
taggaatcg  gatgttggt  agcgtgggg  atctggaag  ggctgggga  tctgtgtcc  2280
tccagctgc  gatacggag  aagaacagc  agaatccaa  cagcaagat  gtgctgctg  2340
acgtgccgg  ccgggcaga  gcccaagtg  agctgcgag  gaactcctt  ccagcctcc  2400
tggtggtgg  agcagaaga  ggtgagagg  agcagaaca  cttggacag  tggggaccc  2460
aagtggagc  cacctatga  ctccacaac  atggccctg  gactgtgaa  ggtcttcac  2520
tcagcatcc  ccttccggg  cagtcccag  cctccgacc  gctctacat  ctggatata  2580
agccccagg  gggccttca  tgcttccca  agcctcctg  caaccctct  aaggtggac  2640
gggggctgc  catccccag  ccctccccc  ttcacccgg  ccatcacaa  cgggatcgc  2700
gacagatct  cctgccaga  cccgagcag  cctcgaggc  tcaggatcc  gttctcgta  2760
gctgcgact  ggcgccctg  actgtggtg  agtgtgacc  gcaggagat  gcgcgcggg  2820
agcgggcca  ggtcacggt  ctggccttc  tgtggctgc  cagcctcta  cagaggcct  2880
tggatcagt  tgtgctgca  tcgcacgca  ggttcaacg  gtcctccct  ccctatgcg  2940
tgcccccgc  cagcctgcc  cgaggggaa  ctcaggtgt  gacacagct  ctccgggcc  3000
tggaggaga  ggccattcc  atctggtgg  tgctggtgg  tgtgctggg  ggcctgctg  3060
tgctcacca  cctggtcct  gccatgtgg  aggtcggct  cttcaagcg  aaccggcac  3120
ccctggaag  agatgatga  gagggggag  gatggtgca  cctacacta  tctagcagg  3180
gggttgggc  tgctacctg  accgcccct  ctccaacaa  ttgcctcca  gctttgggt  3240
ggagctgtt  cattgggtc  tcttggtgt  gtttccctc  caacagagc  gggctaccc  3300
ccctcctgc  gcctaataa  gagactgag  cct  3333



<210> 6118
<211> 1039
<212> PRT
<213> Homo sapiens
<308> P08514
<400> 6118

Met Ala Arg Ala Leu Cys Pro Leu Gln Ala Leu Trp Leu Leu Glu Trp 
  1               5                  10                  15
Val Leu Leu Leu Leu Gly Pro Cys Ala Ala Pro Pro Ala Trp Ala Leu 
             20                  25                  30
Asn Leu Asp Pro Val Gln Leu Thr Phe Tyr Ala Gly Pro Asn Gly Ser 
         35                  40                  45
Gln Phe Gly Phe Ser Leu Asp Phe His Lys Asp Ser His Gly Arg Val 
     50                  55                  60
Ala Ile Val Val Gly Ala Pro Arg Thr Leu Gly Pro Ser Gln Glu Glu 
 65                  70                  75                  80
Thr Gly Gly Val Phe Leu Cys Pro Trp Arg Ala Glu Gly Gly Gln Cys 
                 85                  90                  95
Pro Ser Leu Leu Phe Asp Leu Arg Asp Glu Thr Arg Asn Val Gly Ser 
             100                105                110
Gln Thr Leu Gln Thr Phe Lys Ala Arg Gln Gly Leu Gly Ala Ser Val 
         115                120                125
Val Ser Trp Ser Asp Val Ile Val Ala Cys Ala Pro Trp Gln His Trp 
     130                135                140
Asn Val Leu Glu Lys Thr Glu Glu Ala Glu Lys Thr Pro Val Gly Ser 
 145                150                155                160
Cys Phe Leu Ala Gln Pro Glu Ser Gly Arg Arg Ala Glu Tyr Ser Pro 
                 165                170                175
Cys Arg Gly Asn Thr Leu Ser Arg Ile Tyr Val Glu Asn Asp Phe Ser 
             180                185                190
Trp Asp Lys Arg Tyr Cys Glu Ala Gly Phe Ser Ser Val Val Thr Gln 
         195                200                205
Ala Gly Glu Leu Val Leu Gly Ala Pro Gly Gly Tyr Tyr Phe Leu Gly 
     210                215                220
Leu Leu Ala Gln Ala Pro Val Ala Asp Ile Phe Ser Ser Tyr Arg Pro 
 225                230                235                240
Gly Ile Leu Leu Trp His Val Ser Ser Gln Ser Leu Ser Phe Asp Ser 
                 245                250                255
Ser Asn Pro Glu Tyr Phe Asp Gly Tyr Trp Gly Tyr Ser Val Ala Val 
             260                265                270
Gly Glu Phe Asp Gly Asp Leu Asn Thr Thr Glu Tyr Val Val Gly Ala 
         275                280                285
Pro Thr Trp Ser Trp Thr Leu Gly Ala Val Glu Ile Leu Asp Ser Tyr 
     290                295                300
Tyr Gln Arg Leu His Arg Leu Arg Ala Glu Gln Met Ala Ser Tyr Phe 
 305                310                315                320
Gly His Ser Val Ala Val Thr Asp Val Asn Gly Asp Gly Arg His Asp 
                 325                330                335
Leu Leu Val Gly Ala Pro Leu Tyr Met Glu Ser Arg Ala Asp Arg Lys 
             340                345                350
Leu Ala Glu Val Gly Arg Val Tyr Leu Phe Leu Gln Pro Arg Gly Pro 
         355                360                365
His Ala Leu Gly Ala Pro Ser Leu Leu Leu Thr Gly Thr Gln Leu Tyr 
     370                375                380
Gly Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Arg Asp 
 385                390                395                400
Gly Tyr Asn Asp Ile Ala Val Ala Ala Pro Tyr Gly Gly Pro Ser Gly 
                 405                410                415
Arg Gly Gln Val Leu Val Phe Leu Gly Gln Ser Glu Gly Leu Arg Ser 
             420                425                430
Arg Pro Ser Gln Val Leu Asp Ser Pro Phe Pro Thr Gly Ser Ala Phe 
         435                440                445
Gly Phe Ser Leu Arg Gly Ala Val Asp Ile Asp Asp Asn Gly Tyr Pro 
     450                455                460
Asp Leu Ile Val Gly Ala Tyr Gly Ala Asn Gln Val Ala Val Tyr Arg 
 465                470                475                480
Ala Gln Pro Val Val Lys Ala Ser Val Gln Leu Leu Val Gln Asp Ser 
                 485                490                495
Leu Asn Pro Ala Val Lys Ser Cys Val Leu Pro Gln Thr Lys Thr Pro 
             500                505                510
Val Ser Cys Phe Asn Ile Gln Met Cys Val Gly Ala Thr Gly His Asn 
         515                520                525
Ile Pro Gln Lys Leu Ser Leu Asn Ala Glu Leu Gln Leu Asp Arg Gln 
     530                535                540
Lys Pro Arg Gln Gly Arg Arg Val Leu Leu Leu Gly Ser Gln Gln Ala 
 545                550                555                560
Gly Thr Thr Leu Asn Leu Asp Leu Gly Gly Lys His Ser Pro Ile Cys 
                 565                570                575
His Thr Thr Met Ala Phe Leu Arg Asp Glu Ala Asp Phe Arg Asp Lys 
             580                585                590
Leu Ser Pro Ile Val Leu Ser Leu Asn Val Ser Leu Pro Pro Thr Glu 
         595                600                605
Ala Gly Met Ala Pro Ala Val Val Leu His Gly Asp Thr His Val Gln 
     610                615                620
Glu Gln Thr Arg Ile Val Leu Asp Cys Gly Glu Asp Asp Val Cys Val 
 625                630                635                640
Pro Gln Leu Gln Leu Thr Ala Ser Val Thr Gly Ser Pro Leu Leu Val 
                 645                650                655
Gly Ala Asp Asn Val Leu Glu Leu Gln Met Asp Ala Ala Asn Glu Gly 
             660                665                670
Glu Gly Ala Tyr Glu Ala Glu Leu Ala Val His Leu Pro Gln Gly Ala 
         675                680                685
His Tyr Met Arg Ala Leu Ser Asn Val Glu Gly Phe Glu Arg Leu Ile 
     690                695                700
Cys Asn Gln Lys Lys Glu Asn Glu Thr Arg Val Val Leu Cys Glu Leu 
 705                710                715                720
Gly Asn Pro Met Lys Lys Asn Ala Gln Ile Gly Ile Ala Met Leu Val 
                 725                730                735
Ser Val Gly Asn Leu Glu Glu Ala Gly Glu Ser Val Ser Phe Gln Leu 
             740                745                750
Gln Ile Arg Ser Lys Asn Ser Gln Asn Pro Asn Ser Lys Ile Val Leu 
         755                760                765
Leu Asp Val Pro Val Arg Ala Glu Ala Gln Val Glu Leu Arg Gly Asn 
     770                775                780
Ser Phe Pro Ala Ser Leu Val Val Ala Ala Glu Glu Gly Glu Arg Glu 
 785                790                795                800
Gln Asn Ser Leu Asp Ser Trp Gly Pro Lys Val Glu His Thr Tyr Glu 
                 805                810                815
Leu His Asn Asn Gly Pro Gly Thr Val Asn Gly Leu His Leu Ser Ile 
             820                825                830
His Leu Pro Gly Gln Ser Gln Pro Ser Asp Leu Leu Tyr Ile Leu Asp 
         835                840                845
Ile Gln Pro Gln Gly Gly Leu Gln Cys Phe Pro Gln Pro Pro Val Asn 
     850                855                860
Pro Leu Lys Val Asp Trp Gly Leu Pro Ile Pro Ser Pro Ser Pro Ile 
 865                870                875                880
His Pro Ala His His Lys Arg Asp Arg Arg Gln Ile Phe Leu Pro Glu 
                 885                890                895
Pro Glu Gln Pro Ser Arg Leu Gln Asp Pro Val Leu Val Ser Cys Asp 
             900                905                910
Ser Ala Pro Cys Thr Val Val Gln Cys Asp Leu Gln Glu Met Ala Arg 
         915                920                925
Gly Gln Arg Ala Met Val Thr Val Leu Ala Phe Leu Trp Leu Pro Ser 
     930                935                940
Leu Tyr Gln Arg Pro Leu Asp Gln Phe Val Leu Gln Ser His Ala Trp 
 945                950                955                960
Phe Asn Val Ser Ser Leu Pro Tyr Ala Val Pro Pro Leu Ser Leu Pro 
                 965                970                975
Arg Gly Glu Ala Gln Val Trp Thr Gln Leu Leu Arg Ala Leu Glu Glu 
             980                985                990
Arg Ala Ile Pro Ile Trp Trp Val Leu Val Gly Val Leu Gly Gly Leu 
         995                1000                1005
Leu Leu Leu Thr Ile Leu Val Leu Ala Met Trp Lys Val Gly Phe Phe 
     1010                1015                1020
Lys Arg Asn Arg Pro Pro Leu Glu Glu Asp Asp Glu Glu Gly Glu 
 1025                1030                1035



<210> 6119
<211> 455
<212> DNA
<213> Rattus norvegicus
<308> AA893742
<400> 6119

aagtctgca  tatgacatc  tacatagag  gaaaaagct  cttcctaaa  gatagctat  60
aataatcaa  ccagatttg  tgactgacc  ttcaaggtc  tcttctgca  taacaagtt  120
agttttagc  ggtgtaaag  actgtacaa  aagtcgggt  cattctcaa  attcaacac  180
gggcttccc  accaagagt  tgctggatc  gataccgga  aagggtgtt  cgttcaggt  240
taaatggta  ggaaatgag  aagcagaca  aacaagcca  gcaaattcc  ttcccttgg  300
gctcctctg  cgcctttcc  aagtgtttc  tggaggtca  gaagcctgg  atgacaatc  360
ctgcagtct  ttgacagca  gcacacaag  gcttcatgt  caaagactt  agggcagcc  420
tcttcaaat  cttccttac  ggctttaca  agctt  455



<210> 6120
<211> 251
<212> PRT
<213> Rattus norvegicus
<308> NP_038944
<400> 6120

Met Asp Ser Arg His Leu Leu Thr Ser Gln Cys Ile Thr His Leu Ser 
  1               5                  10                  15
Ser Ile Glu Val Arg Gly Asn Ser Ile Arg Ile Leu Val Met Asn Val 
             20                  25                  30
Asp Val Glu Ala Ile Gln Asn Thr Gly Ser Gln Ser Leu His Phe Leu 
         35                  40                  45
Pro Cys Leu Ile Cys Met Trp Thr Ile Ser Arg Ser Thr Arg Arg His 
     50                  55                  60
Trp Ala Val Leu Met Asp Thr Ser Ile Phe Ser Gly Ser Cys Phe Phe 
 65                  70                  75                  80
Tyr Phe Gly Val His Ser Tyr Ser Ile Leu Leu Val Ala Ala Val Lys 
                 85                  90                  95
Asp Glu Val Val Gly Val Gly Val Arg Cys Ala Met Lys Asn Arg Asn 
             100                105                110
Leu Gly Phe Leu Thr Ser Val Gln Met Pro Ile Leu Glu Gly Thr Phe 
         115                120                125
Ser Cys Glu Arg Leu Tyr Ile Ser Phe Trp Ile Phe Ala Leu Phe Leu 
     130                135                140
Tyr Tyr Arg Lys Val Leu Cys Leu Arg Pro Thr Leu Asn Phe Met Gln 
 145                150                155                160
Tyr Cys Trp Gly Ile Thr Leu Phe Lys Ala Tyr Gly Lys Val Leu Lys 
                 165                170                175
Pro Asp Phe Pro Lys Ile Phe Asn Cys Phe Asn Pro Leu Thr Ser Val 
             180                185                190
Lys Val Cys Ser Val Leu Phe Tyr Ser Thr Gln Leu Thr Met Leu Arg 
         195                200                205
Phe Ile Ser Ala Glu Asn Lys Ile Lys His Val Lys Asn Gly Arg Leu 
     210                215                220
Phe Val Val Thr Met Gln Asn Lys Leu Trp Trp Glu Phe Gly Thr Phe 
 225                230                235                240
Ser Leu Lys Lys Asn Met Leu Val Ala Leu Pro 
                 245                250



<210> 6121
<211> 417
<212> DNA
<213> Homo sapiens
<308> AI377110
<400> 6121

tttgtattg  aatataatc  tttatttta  cactcaacg  ttaagccat  caactacac  60
acacagata  aacggaagt  ataacatat  aaccagtac  tgcccacac  catagcagt  120
aggggaata  aaatcaagg  tgcactgta  ttccatgac  ctaaaaatc  agtctattt  180
acattggtt  gaagcaaca  aacctttat  gcagattcc  ctttttaaa  aaaaaccca  240
ggagagatg  tcaagcaca  atgatcact  catgcattt  attgatagt  tatatttta  300
atctgcagt  tgacatctt  catagggaa  aaagcttct  cctaaaaga  aactattaa  360
aatcaaacc  gctttaata  gattgacct  tcaaggtct  gttttgctt  aaacaag  417



<210> 6122
<211> 520
<212> DNA
<213> Rattus norvegicus
<308> AA893743
<400> 6122

cagaaaaca  gtgttgctt  taatatcaa  tattggagc  tgcaacatt  ctaaataca  60
aagtcatag  agctcacag  tgacttccc  ggctgtcgc  agtcaatga  ggaacagtt  120
cgggcctct  agacatcat  atggatcct  tcttggttt  atttaacga  tatactttc  180
cccttacta  ggcaggtct  attcagaag  ttgctgccc  acagttaca  tttttctta  240
tcctctgag  aggataaag  tgtcatttt  aaaatctac  ttggttcca  gctgtcatg  300
gtgcggaag  ctcagtggt  ggctatcga  gggctatgt  agtattccc  gaaaaatga  360
gatcgtgat  tctgttaca  ggcagaaag  atttctgtg  gctcaggat  aatatgtac  420
gacataaaa  attctcagt  aaaaaaaaa  gttaaactc  acaaattca  cagcttctc  480
ttcattgtt  atgtgttaa  aatggaaaa  tctgtgtttc  520



<210> 6123
<211> 389
<212> DNA
<213> Homo sapiens
<308> AI092788
<400> 6123

ttttttttt  tttcaaaaa  atgggttac  tttaatttt  aattatgtg  gcatgcaac  60
ttgctaaat  caaaagtca  acaagctca  aaatgactt  agagactgc  actcttgta  120
ttaaagaac  atttagggt  tattaagac  tcataaatc  tagatcctt  cctattttc  180
cttgatgac  acacatttt  tccctacta  tactgctac  acaggtttc  cttagaagc  240
ttgctgccc  gcagttaca  ttctttatc  attattgtt  ccctgaaga  aaatagcag  300
atcattcat  ttctaaaat  gtgcattac  acagcatct  agtaagact  aagtatagg  360
catttacca  tggctgttc  gggagtatt  389



<210> 6124
<211> 75
<212> PRT
<213> Homo sapiens
<308> P04541
<400> 6124

Thr Asp Val Glu Thr Thr Tyr Ala Asp Phe Ile Ala Ser Gly Arg Thr 
  1               5                  10                  15
Gly Arg Arg Asn Ala Ile His Asp Ile Leu Val Ser Ser Ala Ser Gly 
             20                  25                  30
Asn Ser Asn Glu Leu Ala Leu Lys Leu Ala Gly Leu Asp Ile Asn Lys 
         35                  40                  45
Thr Glu Gly Glu Glu Asp Ala Gln Arg Ser Ser Thr Glu Gln Ser Gly 
     50                  55                  60
Glu Ala Gln Gly Glu Ala Ala Lys Ser Glu Ser 
 65                  70                  75



<210> 6125
<211> 520
<212> DNA
<213> Rattus norvegicus
<308> AA893743
<400> 6125

cagaaaaca  gtgttgctt  taatatcaa  tattggagc  tgcaacatt  ctaaataca  60
aagtcatag  agctcacag  tgacttccc  ggctgtcgc  agtcaatga  ggaacagtt  120
cgggcctct  agacatcat  atggatcct  tcttggttt  atttaacga  tatactttc  180
cccttacta  ggcaggtct  attcagaag  ttgctgccc  acagttaca  tttttctta  240
tcctctgag  aggataaag  tgtcatttt  aaaatctac  ttggttcca  gctgtcatg  300
gtgcggaag  ctcagtggt  ggctatcga  gggctatgt  agtattccc  gaaaaatga  360
gatcgtgat  tctgttaca  ggcagaaag  atttctgtg  gctcaggat  aatatgtac  420
gacataaaa  attctcagt  aaaaaaaaa  gttaaactc  acaaattca  cagcttctc  480
ttcattgtt  atgtgttaa  aatggaaaa  tctgtgtttc  520



<210> 6126
<211> 389
<212> DNA
<213> Homo sapiens
<308> AI092788
<400> 6126

ttttttttt  tttcaaaaa  atgggttac  tttaatttt  aattatgtg  gcatgcaac  60
ttgctaaat  caaaagtca  acaagctca  aaatgactt  agagactgc  actcttgta  120
ttaaagaac  atttagggt  tattaagac  tcataaatc  tagatcctt  cctattttc  180
cttgatgac  acacatttt  tccctacta  tactgctac  acaggtttc  cttagaagc  240
ttgctgccc  gcagttaca  ttctttatc  attattgtt  ccctgaaga  aaatagcag  300
atcattcat  ttctaaaat  gtgcattac  acagcatct  agtaagact  aagtatagg  360
catttacca  tggctgttc  gggagtatt  389



<210> 6127
<211> 75
<212> PRT
<213> Homo sapiens
<308> P04541
<400> 6127

Thr Asp Val Glu Thr Thr Tyr Ala Asp Phe Ile Ala Ser Gly Arg Thr 
  1               5                  10                  15
Gly Arg Arg Asn Ala Ile His Asp Ile Leu Val Ser Ser Ala Ser Gly 
             20                  25                  30
Asn Ser Asn Glu Leu Ala Leu Lys Leu Ala Gly Leu Asp Ile Asn Lys 
         35                  40                  45
Thr Glu Gly Glu Glu Asp Ala Gln Arg Ser Ser Thr Glu Gln Ser Gly 
     50                  55                  60
Glu Ala Gln Gly Glu Ala Ala Lys Ser Glu Ser 
 65                  70                  75



<210> 6128
<211> 422
<212> DNA
<213> Rattus norvegicus
<308> AA893821
<400> 6128

agtcagcaa  atcaagtcc  cagcatttt  tagtctatc  gtttcctaa  catttgacc  60
aatatattt  ctaaaatct  ccacatttt  agaaaaaca  gttttacct  tctggcaac  120
cacagtcaa  ttcccttat  ttccttctt  gccagtagc  aatgcactc  ccttgaagt  180
ttaatgccc  tcaaagggt  gtggtaaac  caagctcaa  gactgcaag  tcagagtgt  240
gggtaggag  acaggggca  accagcacc  actgttcta  aatccgacc  gcaccagga  300
gtctctccc  gtgtggttc  gacctggct  agcacgttt  aagccctgt  cgtggtacc  360
aaggaggtc  accttgttt  tgatcatgg  ctaactcac  gatgacact  nggcaggat  420
gg  422



<210> 6129
<211> 108
<212> PRT
<213> Rattus norvegicus
<308> BAB26137
<400> 6129

Glu Pro Ser Pro Thr Ala Glu Arg Thr Glu Ser Leu Pro Gly His His 
  1               5                  10                  15
Ser Gly Ala Cys Gly Ser Ala Gly Ala Gln Val Asp Ser Ile Val Asp 
             20                  25                  30
Pro Met Leu Asp Leu Asp Ile Gln Glu Leu Ala Ser Leu Thr Thr Gly 
         35                  40                  45
Gly Gly Asp Leu Glu Asn Phe Glu Arg Leu Phe Ser Lys Leu Lys Glu 
     50                  55                  60
Met Lys Asp Lys Ala Ala Thr Leu Pro His Glu Gln Arg Lys Leu His 
 65                  70                  75                  80
Ala Glu Lys Val Ala Lys Ala Phe Trp Met Ala Ile Gly Gly Asp Arg 
                 85                  90                  95
Asp Glu Ile Glu Gly Leu Ser Ser Asp Asp Glu His 
             100                105



<210> 6130
<211> 2105
<212> DNA
<213> Homo sapiens
<308> XM_015846
<400> 6130

agcgcagct  tggctgctg  cgtaccctg  gcgttagtc  ccagctgct  ctccgtctt  60
tcaggagac  agctggtcc  acatatcct  ggaacagaa  atcttattg  ggaagtgac  120
tccaatgat  ctgtgagat  ttatccctg  accattgat  ataaatact  ttcagcaga  180
atcaatcta  gtgtggtgc  aaacaaatt  cttgttact  cagagattg  agaatctgt  240
caagcattt  tggtttact  tgacagcac  caaaaatcg  gccttgata  tgtctcctc  300
tggcttcca  tggcaaaag  atggttacc  gaggtgatg  tcttggtct  cgatagagt  360
tctgaagat  gtataaacc  acaaaaagc  caagaatgg  gcatcaaac  tggctttga  420
ttggtagaa  ttagtccag  ggagttgcc  gaggaggat  atgacttcc  agaatctac  480
ggagtaaag  gaattgtcc  agccctgaa  gccaatgtg  ggtccaatg  agtgatgaa  540
aatgatagg  accaaggct  tagccttct  aactcattg  ctggaacaa  ccatagcat  600
gggtcagca  atccctgtc  cccagagca  ccccatttg  cagcagcag  tagtactga  660
tccctctct  atcatcggg  tggtgcatc  aacacaaca  atgcccagg  tgatagcat  720
gtggatccc  tgttagatc  ggatattca  gaattagcc  gtcttacca  tggaggagg  780
gatgtggag  attttgaaa  actcttttc  aagttaaag  aaatgaaag  caaggctgc  840
acgcttcct  atgagcaaa  aaaagtgca  gcagaaaag  tggccaaag  attctggat  900
gcaatcggg  gagacagag  tgaaattga  ggcctttca  ctgatgaag  gcactgaat  960
attcatact  gggtttgac  aacaaagat  ctagctgtc  ctgagatac  tctctactc  1020
gcccagtca  attttgcca  aattgccct  atcatgttg  ctgcctgac  tgtttatag  1080
gtcccctta  ttttagttt  tagtaggag  ttaaggaga  atctttttt  tcctcagta  1140
attgtaaga  agtgaggaa  acagtgata  taatgagtg  ggatttctt  aatatactt  1200
ttttttgtt  taggaatga  ggtaggata  atctcagag  tctgtgtga  ttactcaag  1260
tgaagacaa  ctccaggcc  ttcctggtc  accttttaa  tagcatttc  agcattcac  1320
cttgatact  cacatcagg  gttgtgtca  ctttcctgg  tgatttggg  tttctccat  1380
caaggagct  gtagctctg  gctatgatg  ttttattgg  aggaaagga  gcagctgca  1440
aattgatgt  agctatgtg  ggccgaagt  tcagcccgc  gctaagtct  tacctaaga  1500
aatgcctct  ggcattctt  tgaagtata  tgtctgagc  catgctaga  agaatcaaa  1560
agccagtgt  gatttttag  ctgtaataa  tgaggcaaa  gatttctat  ccagtggga  1620
gaaaacctc  ctactgagt  gtgggggat  tgttgtatg  tagagagaa  cttaaggag  1680
ccttgtatg  gccatggag  cagtatgtg  taacatacc  tgattttca  gaagaaatt  1740
ttctgtctt  gagttctcc  ctgctgctt  agatgccag  gctgtgttg  tgcacacct  1800
caaaacaag  cacatttcc  cctttctct  taaagccaa  gagagatca  tgccaaagt  1860
ggagcacta  ggggtgggt  gggaagtga  atgttaggc  atgaattcc  gagcacctt  1920
tttttcttc  aaggttcgt  gctcctctc  gcccttcca  gcctgtaac  tcggaggac  1980
atcttttgt  ctttatcct  tgtcttgtt  gagtgggtc  gccccagag  aactgataa  2040
caaatggca  gtttttaaa  gaagagtgg  aagtactgc  aataaaaat  cttatttgt  2100
tttgt  2105



<210> 6131
<211> 315
<212> PRT
<213> Homo sapiens
<308> XP_015846
<400> 6131

Met Ala Ala Gly Val Pro Cys Ala Leu Val Thr Ser Cys Ser Ser Val 
  1               5                  10                  15
Phe Ser Gly Asp Gln Leu Val Gln His Ile Leu Gly Thr Glu Asp Leu 
             20                  25                  30
Ile Val Glu Val Thr Ser Asn Asp Ala Val Arg Phe Tyr Pro Trp Thr 
         35                  40                  45
Ile Asp Asn Lys Tyr Tyr Ser Ala Asp Ile Asn Leu Cys Val Val Pro 
     50                  55                  60
Asn Lys Phe Leu Val Thr Ala Glu Ile Ala Glu Ser Val Gln Ala Phe 
 65                  70                  75                  80
Val Val Tyr Phe Asp Ser Thr Gln Lys Ser Gly Leu Asp Ser Val Ser 
                 85                  90                  95
Ser Trp Leu Pro Leu Ala Lys Ala Trp Leu Pro Glu Val Met Ile Leu 
             100                105                110
Val Cys Asp Arg Val Ser Glu Asp Gly Ile Asn Arg Gln Lys Ala Gln 
         115                120                125
Glu Trp Cys Ile Lys His Gly Phe Glu Leu Val Glu Leu Ser Pro Glu 
     130                135                140
Glu Leu Pro Glu Glu Asp Asp Asp Phe Pro Glu Ser Thr Gly Val Lys 
 145                150                155                160
Arg Ile Val Gln Ala Leu Asn Ala Asn Val Trp Ser Asn Val Val Met 
                 165                170                175
Lys Asn Asp Arg Asn Gln Gly Phe Ser Leu Leu Asn Ser Leu Thr Gly 
             180                185                190
Thr Asn His Ser Ile Gly Ser Ala Asp Pro Cys His Pro Glu Gln Pro 
         195                200                205
His Leu Pro Ala Ala Asp Ser Thr Glu Ser Leu Ser Asp His Arg Gly 
     210                215                220
Gly Ala Ser Asn Thr Thr Asp Ala Gln Val Asp Ser Ile Val Asp Pro 
 225                230                235                240
Met Leu Asp Leu Asp Ile Gln Glu Leu Ala Ser Leu Thr Thr Gly Gly 
                 245                250                255
Gly Asp Val Glu Asn Phe Glu Arg Leu Phe Ser Lys Leu Lys Glu Met 
             260                265                270
Lys Asp Lys Ala Ala Thr Leu Pro His Glu Gln Arg Lys Val His Ala 
         275                280                285
Glu Lys Val Ala Lys Ala Phe Trp Met Ala Ile Gly Gly Asp Arg Asp 
     290                295                300
Glu Ile Glu Gly Leu Ser Ser Asp Glu Glu His 
 305                310                315



<210> 6132
<211> 417
<212> DNA
<213> Rattus norvegicus
<308> AA893870
<400> 6132

cctactcag  ctttattca  agaccaaga  gtataggtg  aagggaggg  agaagggcc  60
ggtcagaag  caagcccgg  aggaggcgg  ttaaaaccc  aaaggtcag  aggatcgtg  120
ggccccgct  tcacggtct  tattcgtac  gaaaatcaa  atcaagcga  cttttgccc  180
tctgctcca  gggaggttt  tgtcctccc  gagctcgcc  taggacacc  gcgttaccg  240
ttgacaggt  taccgcccc  gtcaaactc  ccacctggc  ctgtccccg  agcgggtcg  300
gcccgcccg  acgcgcgga  gggcgcttg  agccagaag  gagagcccc  cggggctcg  360
ccccccgcc  caccgggtc  gtgaaaaaa  gatgagagt  gtggtattt  accggcg  417



<210> 6133
<211> 5025
<212> DNA
<213> Homo sapiens
<308> M11167
<400> 6133

cgcgacctc  gatcagacg  ggcgacccg  tgaatttaa  catattagt  agcggagga  60
aagaaacta  ccaggattc  ctcagtaac  gcgagtgaa  agggaagag  ccagcgccg  120
atccccgcc  cgcggggcg  gggacatgt  gcgtacgga  gacccgctc  ccggcgccg  180
tcgtggggg  cccaagtcc  tctgatcga  gcccagccc  tggacggtg  gaggccggt  240
gcggccggc  cgcgcccgg  tcttcccgg  gtcgggttg  ttgggaatg  agcccaaag  300
gggtggtaa  ctccatcta  ggctaaata  cggcacgag  ccgatagtc  acaagtacc  360
taagggaaa  ttgaaaaga  ctttgaaga  agagttcaa  agggcgtga  accgttaag  420
ggtaaacgg  tggggtccg  gcagtccgc  cggaggatt  aacccggcg  cgggtccgg  480
cgtgtcggc  gcccggcgg  tctttcccg  cccccgttc  tcccgaccc  tccacccgc  540
ctcccttcc  ccgccgccc  tcctcctcc  ccccggagg  ggcgggctc  ggcgggtgc  600
ggggtgggc  ggcggggcc  ggggtgggg  cggcggggg  ccgtccccc  gaccggcga  660
cggccgccg  cgggcgcat  tccaggcgg  gcgccgcga  cggctccgg  acggctggg  720
aggcccggc  gggaaggtg  ctcgggggg  cccgtccgt  cgtccgtcc  cctcctccc  780
cgtctccgc  ccccggccc  gcgtcctcc  tcgggaggg  gcgcgggtc  gggcggcgg  840
ggcggcggc  gtggcggcg  cggcggggg  ggcgggacc  aaacccccc  cgagtgtta  900
agccccccc  gcagcagca  tcgccgaat  ccggggccg  gggagcgag  cccgtcgcc  960
cgctctccc  cctcccggc  cccaccccc  cgggaatcc  cgcgagggg  gtctccccc  1020
gcgcggcgc  ggcgtctcc  cgtgggggg  ccgggccac  cctcccacg  cgcgaccgc  1080
ctcccaccc  tcctccccg  gcccccgcc  cggcgacgg  gggggtgcc  cgcgcgggt  1140
ggggggcgg  gcggactgt  cccagtgcg  cccgggcgg  tcgcgccgt  gggcccggg  1200
gaggttctc  cggggccac  cgcgcgtcc  ccgaagagg  ggacggcgg  gcgagcgca  1260
ggggtcggc  gcgacgtcg  ctacccacc  gacccgtct  gaaacacgg  ccaaggagt  1320
taacacgtg  gcgagtcgg  ggctcgcac  aaagccgcc  tggcgcaat  aaggtgaag  1380
ccggcgcgc  cgccggccg  ggtgggatc  cgaggcctc  ccagtccgc  gaggggcac  1440
accggcccg  ctcgcccgc  gcgccgggg  ggtggagca  gagcgcacg  gttaggacc  1500
gaaagatgg  gaactatgc  tgggcaggg  gaagccaga  gaaactctg  tggaggtcc  1560
tagcggtcc  gacgtgcaa  tcggtcgtc  gacctgggt  taggggcga  agactaatc  1620
aaccatcta  tagctggtt  cctccgaag  ttccctcag  atagctggc  ctctcgcag  1680
cccgacgca  ccccgccac  cagttttat  cggtaaagc  aatgattag  ggtcttggg  1740
ccgaaacga  ctcaaccta  tctcaaact  taaatgggt  agaagcccg  ctcgctggc  1800
tggagccgg  gtggaatgc  agtgcctag  gggccactt  tggtaagca  aactggcgc  1860
gcgggatga  ccgaacgcc  ggttaaggc  cccgatgcc  acgctcatc  gaccccaga  1920
aaggtgttg  ttgatatag  cagcaggac  gtggccatg  aagtcggaa  ccgctaagg  1980
gtgtgtaac  actcacctg  cgaatcaac  agccctgaa  atggatggc  ctggagcgt  2040
gggcccata  ccggccgtc  ccggcagtc  agagtggac  ggagcggcg  gggcggcgg  2100
gcgcgcgcg  gtgtggtgt  cgtcggagg  cggcggcgg  ggcggcggc  ggggtgtgg  2160
gtccttccc  cgccccccc  cccacgcct  ctcccctcc  cccgcccac  ccccgctcc  2220
cgcccccgg  gccccgcgg  gctacgccg  gacgagtag  agggccgct  cggtgagcc  2280
tgaagccta  ggcgcgggc  cgggtggag  ccgccgcag  tgcagatct  ggtggtagt  2340
gcaaatatt  aaacgagaa  tttgaaggc  gaagtggag  agggttcca  gtgaacagc  2400
gttgaacat  ggtcagtcg  tcctgagag  tgggcgagc  ccgttccga  gggacgggc  2460
atggcctcc  ttgccctcg  ccgatcgaa  gggagtcgg  ttcagatcc  cgaatccgg  2520
gtggcggag  tgggcgccg  gaggcgtcc  gtgcggtaa  gcgaccgat  ccggagaag  2580
cggcgggag  cccggggag  gttctcttt  ctttgtgaa  ggcagggcg  cctggaatg  2640
gttcgcccc  agagagggg  ccgtgcctt  gaaagcgtc  cggttccgg  ggcgtccgg  2700
gagctctcg  tggcccttg  aaatccggg  gagagggtg  aaatctcgc  ccgggccgt  2760
cccatatcc  cagcaggtc  ccaaggtga  cagcctctg  catgttgga  caatgtagg  2820
aagggaagt  ggcaagccg  atccgtaac  tcgggataa  gattggctc  aagggctgg  2880
tcggtcggg  tggggcgcg  agcggggct  ggcgcgcgc  gcggctgga  gaggcgcgc  2940
cccccccca  gcccggggc  cccccctcg  ggccctccc  cgccccacc  gcgcgcgcc  3000
ctcgctccc  ccccacccc  cgccctctc  ctctctctc  cccccgctc  ccgtcctcc  3060
ccctccccg  gggagcgcc  cgtgggggc  cggcggggg  agaagggtc  gggcggcag  3120
ggccgcgcg  cggccgccg  ggcggccgg  gggggcagg  ccccgcgag  ggggccccg  3180
ggacccggg  ggccggcgg  ggcgcggac  ctggacgcg  gccgggccc  tcccgtgga  3240
cgccccagc  gcggcgggc  tcgcggccg  ccccgggga  cccggcggc  gcgcggcgc  3300
ccccccacc  ccaccccac  tctcggtcg  gcgcgcgtc  gctgggggc  ggagcggtc  3360
ggcggcggc  gtcggcggg  ggcggggcg  ggcggttcg  ccccccgcc  taccccccc  3420
gccccgtcc  ccccccgtt  ccccctcct  ctcggcgcg  ggcggcggc  gcggcaggc  3480
gcggagggg  cgcgggccg  tcccccccg  cgggtccgc  cccggggcc  cggttccgc  3540
cgcgcctcg  ctcggccgg  gcctagcag  cgacttaga  ctggtgcgg  ccaggggaa  3600
ccgactgtt  aattaaaac  aagcatcgc  aaggcccgc  gcgggtgtt  acgcgatgt  3660
atttctgcc  agtgctctg  atgtcaaag  gaagaaatt  aatgaagcg  gggtaaacg  3720
cgggagtaa  tatgactct  ttaaggtag  caaatgcct  gtcatctaa  tagtgacgc  3780
catgaatgg  tgaacgaga  tcccactgt  cctacctac  atccagcga  accacagcc  3840
agggaacgg  cttggcgga  tcagcgggg  aagaagacc  tgttgagct  gactctagt  3900
tggcacggt  aagagacat  agaggtgta  aataagtgg  aggcccccg  cgccccccc  3960
gtgtccccg  gaggggccc  gggcggggt  cgcggccct  cgggccgcc  gtgaaatac  4020
actactctg  tcgtttttt  actgacccg  tgaggcggg  gggcgagcc  gaggggctc  4080
cgcttctgg  gccaagcgc  cgcccggcc  ggcgcgacc  gctccgggg  cagtgccag  4140
tggggagtt  gactggggc  gtacacctg  caaacggta  cgcaggtgt  ctaaggcga  4200
ctcagggag  acagaaacc  cccgtggag  agaagggca  aagctcgct  gatcttgat  4260
ttcagtacg  atacagacc  tgaaagcgg  gcctcacga  ccttctgac  ttttgggtt  4320
taagcagga  gtgtcagaa  agttaccac  gggataact  gcttgtggc  gccaagcgt  4380
catagcgac  tcgcttttt  atccttcga  gtcggctct  cctatcatt  tgaagcaga  4440
ttcgccaag  gttggattg  tcacccact  atagggaac  tgagctggg  ttagaccgt  4500
gtgagacag  ttagtttta  cctactgat  atgtgttgt  gccatggta  tcctgctca  4560
tacgagagg  accgcaggt  cagacattt  gtgtatgtg  ttggctgag  agccaatgg  4620
gcgaagcta  catctgtgg  attatgact  aacgcctct  agtcagaat  ccgcccagg  4680
gaacgatac  gcagcgccg  ggagcctcg  ttggcctcg  atagccggt  ccccgcctg  4740
ccccgccgg  gggccgccc  cccctccac  cgccccgcc  cgggagggc  cgtgccccg  4800
cgcgcgccg  gaccggggt  cggtgcgga  tgcccttcg  cctgggaaa  ggggcgcgg  4860
cggaaaggc  gccgccccc  cgcccgtca  gcaccgcac  ttcgtgggg  acctggcgc  4920
aaaccattc  tagacgacc  gcttctggg  cggggtttc  tacgtagca  agcagctcc  4980
tcgctgcga  ctattgaaa  tcagccctc  acacaaggg  ttgtc  5025



<210> 6134
<211> 417
<212> DNA
<213> Rattus norvegicus
<308> AA893870
<400> 6134

cctactcag  ctttattca  agaccaaga  gtataggtg  aagggaggg  agaagggcc  60
ggtcagaag  caagcccgg  aggaggcgg  ttaaaaccc  aaaggtcag  aggatcgtg  120
ggccccgct  tcacggtct  tattcgtac  gaaaatcaa  atcaagcga  cttttgccc  180
tctgctcca  gggaggttt  tgtcctccc  gagctcgcc  taggacacc  gcgttaccg  240
ttgacaggt  taccgcccc  gtcaaactc  ccacctggc  ctgtccccg  agcgggtcg  300
gcccgcccg  acgcgcgga  gggcgcttg  agccagaag  gagagcccc  cggggctcg  360
ccccccgcc  caccgggtc  gtgaaaaaa  gatgagagt  gtggtattt  accggcg  417



<210> 6135
<211> 5025
<212> DNA
<213> Homo sapiens
<308> M11167
<400> 6135

cgcgacctc  gatcagacg  ggcgacccg  tgaatttaa  catattagt  agcggagga  60
aagaaacta  ccaggattc  ctcagtaac  gcgagtgaa  agggaagag  ccagcgccg  120
atccccgcc  cgcggggcg  gggacatgt  gcgtacgga  gacccgctc  ccggcgccg  180
tcgtggggg  cccaagtcc  tctgatcga  gcccagccc  tggacggtg  gaggccggt  240
gcggccggc  cgcgcccgg  tcttcccgg  gtcgggttg  ttgggaatg  agcccaaag  300
gggtggtaa  ctccatcta  ggctaaata  cggcacgag  ccgatagtc  acaagtacc  360
taagggaaa  ttgaaaaga  ctttgaaga  agagttcaa  agggcgtga  accgttaag  420
ggtaaacgg  tggggtccg  gcagtccgc  cggaggatt  aacccggcg  cgggtccgg  480
cgtgtcggc  gcccggcgg  tctttcccg  cccccgttc  tcccgaccc  tccacccgc  540
ctcccttcc  ccgccgccc  tcctcctcc  ccccggagg  ggcgggctc  ggcgggtgc  600
ggggtgggc  ggcggggcc  ggggtgggg  cggcggggg  ccgtccccc  gaccggcga  660
cggccgccg  cgggcgcat  tccaggcgg  gcgccgcga  cggctccgg  acggctggg  720
aggcccggc  gggaaggtg  ctcgggggg  cccgtccgt  cgtccgtcc  cctcctccc  780
cgtctccgc  ccccggccc  gcgtcctcc  tcgggaggg  gcgcgggtc  gggcggcgg  840
ggcggcggc  gtggcggcg  cggcggggg  ggcgggacc  aaacccccc  cgagtgtta  900
agccccccc  gcagcagca  tcgccgaat  ccggggccg  gggagcgag  cccgtcgcc  960
cgctctccc  cctcccggc  cccaccccc  cgggaatcc  cgcgagggg  gtctccccc  1020
gcgcggcgc  ggcgtctcc  cgtgggggg  ccgggccac  cctcccacg  cgcgaccgc  1080
ctcccaccc  tcctccccg  gcccccgcc  cggcgacgg  gggggtgcc  cgcgcgggt  1140
ggggggcgg  gcggactgt  cccagtgcg  cccgggcgg  tcgcgccgt  gggcccggg  1200
gaggttctc  cggggccac  cgcgcgtcc  ccgaagagg  ggacggcgg  gcgagcgca  1260
ggggtcggc  gcgacgtcg  ctacccacc  gacccgtct  gaaacacgg  ccaaggagt  1320
taacacgtg  gcgagtcgg  ggctcgcac  aaagccgcc  tggcgcaat  aaggtgaag  1380
ccggcgcgc  cgccggccg  ggtgggatc  cgaggcctc  ccagtccgc  gaggggcac  1440
accggcccg  ctcgcccgc  gcgccgggg  ggtggagca  gagcgcacg  gttaggacc  1500
gaaagatgg  gaactatgc  tgggcaggg  gaagccaga  gaaactctg  tggaggtcc  1560
tagcggtcc  gacgtgcaa  tcggtcgtc  gacctgggt  taggggcga  agactaatc  1620
aaccatcta  tagctggtt  cctccgaag  ttccctcag  atagctggc  ctctcgcag  1680
cccgacgca  ccccgccac  cagttttat  cggtaaagc  aatgattag  ggtcttggg  1740
ccgaaacga  ctcaaccta  tctcaaact  taaatgggt  agaagcccg  ctcgctggc  1800
tggagccgg  gtggaatgc  agtgcctag  gggccactt  tggtaagca  aactggcgc  1860
gcgggatga  ccgaacgcc  ggttaaggc  cccgatgcc  acgctcatc  gaccccaga  1920
aaggtgttg  ttgatatag  cagcaggac  gtggccatg  aagtcggaa  ccgctaagg  1980
gtgtgtaac  actcacctg  cgaatcaac  agccctgaa  atggatggc  ctggagcgt  2040
gggcccata  ccggccgtc  ccggcagtc  agagtggac  ggagcggcg  gggcggcgg  2100
gcgcgcgcg  gtgtggtgt  cgtcggagg  cggcggcgg  ggcggcggc  ggggtgtgg  2160
gtccttccc  cgccccccc  cccacgcct  ctcccctcc  cccgcccac  ccccgctcc  2220
cgcccccgg  gccccgcgg  gctacgccg  gacgagtag  agggccgct  cggtgagcc  2280
tgaagccta  ggcgcgggc  cgggtggag  ccgccgcag  tgcagatct  ggtggtagt  2340
gcaaatatt  aaacgagaa  tttgaaggc  gaagtggag  agggttcca  gtgaacagc  2400
gttgaacat  ggtcagtcg  tcctgagag  tgggcgagc  ccgttccga  gggacgggc  2460
atggcctcc  ttgccctcg  ccgatcgaa  gggagtcgg  ttcagatcc  cgaatccgg  2520
gtggcggag  tgggcgccg  gaggcgtcc  gtgcggtaa  gcgaccgat  ccggagaag  2580
cggcgggag  cccggggag  gttctcttt  ctttgtgaa  ggcagggcg  cctggaatg  2640
gttcgcccc  agagagggg  ccgtgcctt  gaaagcgtc  cggttccgg  ggcgtccgg  2700
gagctctcg  tggcccttg  aaatccggg  gagagggtg  aaatctcgc  ccgggccgt  2760
cccatatcc  cagcaggtc  ccaaggtga  cagcctctg  catgttgga  caatgtagg  2820
aagggaagt  ggcaagccg  atccgtaac  tcgggataa  gattggctc  aagggctgg  2880
tcggtcggg  tggggcgcg  agcggggct  ggcgcgcgc  gcggctgga  gaggcgcgc  2940
cccccccca  gcccggggc  cccccctcg  ggccctccc  cgccccacc  gcgcgcgcc  3000
ctcgctccc  ccccacccc  cgccctctc  ctctctctc  cccccgctc  ccgtcctcc  3060
ccctccccg  gggagcgcc  cgtgggggc  cggcggggg  agaagggtc  gggcggcag  3120
ggccgcgcg  cggccgccg  ggcggccgg  gggggcagg  ccccgcgag  ggggccccg  3180
ggacccggg  ggccggcgg  ggcgcggac  ctggacgcg  gccgggccc  tcccgtgga  3240
cgccccagc  gcggcgggc  tcgcggccg  ccccgggga  cccggcggc  gcgcggcgc  3300
ccccccacc  ccaccccac  tctcggtcg  gcgcgcgtc  gctgggggc  ggagcggtc  3360
ggcggcggc  gtcggcggg  ggcggggcg  ggcggttcg  ccccccgcc  taccccccc  3420
gccccgtcc  ccccccgtt  ccccctcct  ctcggcgcg  ggcggcggc  gcggcaggc  3480
gcggagggg  cgcgggccg  tcccccccg  cgggtccgc  cccggggcc  cggttccgc  3540
cgcgcctcg  ctcggccgg  gcctagcag  cgacttaga  ctggtgcgg  ccaggggaa  3600
ccgactgtt  aattaaaac  aagcatcgc  aaggcccgc  gcgggtgtt  acgcgatgt  3660
atttctgcc  agtgctctg  atgtcaaag  gaagaaatt  aatgaagcg  gggtaaacg  3720
cgggagtaa  tatgactct  ttaaggtag  caaatgcct  gtcatctaa  tagtgacgc  3780
catgaatgg  tgaacgaga  tcccactgt  cctacctac  atccagcga  accacagcc  3840
agggaacgg  cttggcgga  tcagcgggg  aagaagacc  tgttgagct  gactctagt  3900
tggcacggt  aagagacat  agaggtgta  aataagtgg  aggcccccg  cgccccccc  3960
gtgtccccg  gaggggccc  gggcggggt  cgcggccct  cgggccgcc  gtgaaatac  4020
actactctg  tcgtttttt  actgacccg  tgaggcggg  gggcgagcc  gaggggctc  4080
cgcttctgg  gccaagcgc  cgcccggcc  ggcgcgacc  gctccgggg  cagtgccag  4140
tggggagtt  gactggggc  gtacacctg  caaacggta  cgcaggtgt  ctaaggcga  4200
ctcagggag  acagaaacc  cccgtggag  agaagggca  aagctcgct  gatcttgat  4260
ttcagtacg  atacagacc  tgaaagcgg  gcctcacga  ccttctgac  ttttgggtt  4320
taagcagga  gtgtcagaa  agttaccac  gggataact  gcttgtggc  gccaagcgt  4380
catagcgac  tcgcttttt  atccttcga  gtcggctct  cctatcatt  tgaagcaga  4440
ttcgccaag  gttggattg  tcacccact  atagggaac  tgagctggg  ttagaccgt  4500
gtgagacag  ttagtttta  cctactgat  atgtgttgt  gccatggta  tcctgctca  4560
tacgagagg  accgcaggt  cagacattt  gtgtatgtg  ttggctgag  agccaatgg  4620
gcgaagcta  catctgtgg  attatgact  aacgcctct  agtcagaat  ccgcccagg  4680
gaacgatac  gcagcgccg  ggagcctcg  ttggcctcg  atagccggt  ccccgcctg  4740
ccccgccgg  gggccgccc  cccctccac  cgccccgcc  cgggagggc  cgtgccccg  4800
cgcgcgccg  gaccggggt  cggtgcgga  tgcccttcg  cctgggaaa  ggggcgcgg  4860
cggaaaggc  gccgccccc  cgcccgtca  gcaccgcac  ttcgtgggg  acctggcgc  4920
aaaccattc  tagacgacc  gcttctggg  cggggtttc  tacgtagca  agcagctcc  4980
tcgctgcga  ctattgaaa  tcagccctc  acacaaggg  ttgtc  5025



<210> 6136
<211> 417
<212> DNA
<213> Rattus norvegicus
<308> AA893870
<400> 6136

cctactcag  ctttattca  agaccaaga  gtataggtg  aagggaggg  agaagggcc  60
ggtcagaag  caagcccgg  aggaggcgg  ttaaaaccc  aaaggtcag  aggatcgtg  120
ggccccgct  tcacggtct  tattcgtac  gaaaatcaa  atcaagcga  cttttgccc  180
tctgctcca  gggaggttt  tgtcctccc  gagctcgcc  taggacacc  gcgttaccg  240
ttgacaggt  taccgcccc  gtcaaactc  ccacctggc  ctgtccccg  agcgggtcg  300
gcccgcccg  acgcgcgga  gggcgcttg  agccagaag  gagagcccc  cggggctcg  360
ccccccgcc  caccgggtc  gtgaaaaaa  gatgagagt  gtggtattt  accggcg  417



<210> 6137
<211> 5025
<212> DNA
<213> Homo sapiens
<308> M11167
<400> 6137

cgcgacctc  gatcagacg  ggcgacccg  tgaatttaa  catattagt  agcggagga  60
aagaaacta  ccaggattc  ctcagtaac  gcgagtgaa  agggaagag  ccagcgccg  120
atccccgcc  cgcggggcg  gggacatgt  gcgtacgga  gacccgctc  ccggcgccg  180
tcgtggggg  cccaagtcc  tctgatcga  gcccagccc  tggacggtg  gaggccggt  240
gcggccggc  cgcgcccgg  tcttcccgg  gtcgggttg  ttgggaatg  agcccaaag  300
gggtggtaa  ctccatcta  ggctaaata  cggcacgag  ccgatagtc  acaagtacc  360
taagggaaa  ttgaaaaga  ctttgaaga  agagttcaa  agggcgtga  accgttaag  420
ggtaaacgg  tggggtccg  gcagtccgc  cggaggatt  aacccggcg  cgggtccgg  480
cgtgtcggc  gcccggcgg  tctttcccg  cccccgttc  tcccgaccc  tccacccgc  540
ctcccttcc  ccgccgccc  tcctcctcc  ccccggagg  ggcgggctc  ggcgggtgc  600
ggggtgggc  ggcggggcc  ggggtgggg  cggcggggg  ccgtccccc  gaccggcga  660
cggccgccg  cgggcgcat  tccaggcgg  gcgccgcga  cggctccgg  acggctggg  720
aggcccggc  gggaaggtg  ctcgggggg  cccgtccgt  cgtccgtcc  cctcctccc  780
cgtctccgc  ccccggccc  gcgtcctcc  tcgggaggg  gcgcgggtc  gggcggcgg  840
ggcggcggc  gtggcggcg  cggcggggg  ggcgggacc  aaacccccc  cgagtgtta  900
agccccccc  gcagcagca  tcgccgaat  ccggggccg  gggagcgag  cccgtcgcc  960
cgctctccc  cctcccggc  cccaccccc  cgggaatcc  cgcgagggg  gtctccccc  1020
gcgcggcgc  ggcgtctcc  cgtgggggg  ccgggccac  cctcccacg  cgcgaccgc  1080
ctcccaccc  tcctccccg  gcccccgcc  cggcgacgg  gggggtgcc  cgcgcgggt  1140
ggggggcgg  gcggactgt  cccagtgcg  cccgggcgg  tcgcgccgt  gggcccggg  1200
gaggttctc  cggggccac  cgcgcgtcc  ccgaagagg  ggacggcgg  gcgagcgca  1260
ggggtcggc  gcgacgtcg  ctacccacc  gacccgtct  gaaacacgg  ccaaggagt  1320
taacacgtg  gcgagtcgg  ggctcgcac  aaagccgcc  tggcgcaat  aaggtgaag  1380
ccggcgcgc  cgccggccg  ggtgggatc  cgaggcctc  ccagtccgc  gaggggcac  1440
accggcccg  ctcgcccgc  gcgccgggg  ggtggagca  gagcgcacg  gttaggacc  1500
gaaagatgg  gaactatgc  tgggcaggg  gaagccaga  gaaactctg  tggaggtcc  1560
tagcggtcc  gacgtgcaa  tcggtcgtc  gacctgggt  taggggcga  agactaatc  1620
aaccatcta  tagctggtt  cctccgaag  ttccctcag  atagctggc  ctctcgcag  1680
cccgacgca  ccccgccac  cagttttat  cggtaaagc  aatgattag  ggtcttggg  1740
ccgaaacga  ctcaaccta  tctcaaact  taaatgggt  agaagcccg  ctcgctggc  1800
tggagccgg  gtggaatgc  agtgcctag  gggccactt  tggtaagca  aactggcgc  1860
gcgggatga  ccgaacgcc  ggttaaggc  cccgatgcc  acgctcatc  gaccccaga  1920
aaggtgttg  ttgatatag  cagcaggac  gtggccatg  aagtcggaa  ccgctaagg  1980
gtgtgtaac  actcacctg  cgaatcaac  agccctgaa  atggatggc  ctggagcgt  2040
gggcccata  ccggccgtc  ccggcagtc  agagtggac  ggagcggcg  gggcggcgg  2100
gcgcgcgcg  gtgtggtgt  cgtcggagg  cggcggcgg  ggcggcggc  ggggtgtgg  2160
gtccttccc  cgccccccc  cccacgcct  ctcccctcc  cccgcccac  ccccgctcc  2220
cgcccccgg  gccccgcgg  gctacgccg  gacgagtag  agggccgct  cggtgagcc  2280
tgaagccta  ggcgcgggc  cgggtggag  ccgccgcag  tgcagatct  ggtggtagt  2340
gcaaatatt  aaacgagaa  tttgaaggc  gaagtggag  agggttcca  gtgaacagc  2400
gttgaacat  ggtcagtcg  tcctgagag  tgggcgagc  ccgttccga  gggacgggc  2460
atggcctcc  ttgccctcg  ccgatcgaa  gggagtcgg  ttcagatcc  cgaatccgg  2520
gtggcggag  tgggcgccg  gaggcgtcc  gtgcggtaa  gcgaccgat  ccggagaag  2580
cggcgggag  cccggggag  gttctcttt  ctttgtgaa  ggcagggcg  cctggaatg  2640
gttcgcccc  agagagggg  ccgtgcctt  gaaagcgtc  cggttccgg  ggcgtccgg  2700
gagctctcg  tggcccttg  aaatccggg  gagagggtg  aaatctcgc  ccgggccgt  2760
cccatatcc  cagcaggtc  ccaaggtga  cagcctctg  catgttgga  caatgtagg  2820
aagggaagt  ggcaagccg  atccgtaac  tcgggataa  gattggctc  aagggctgg  2880
tcggtcggg  tggggcgcg  agcggggct  ggcgcgcgc  gcggctgga  gaggcgcgc  2940
cccccccca  gcccggggc  cccccctcg  ggccctccc  cgccccacc  gcgcgcgcc  3000
ctcgctccc  ccccacccc  cgccctctc  ctctctctc  cccccgctc  ccgtcctcc  3060
ccctccccg  gggagcgcc  cgtgggggc  cggcggggg  agaagggtc  gggcggcag  3120
ggccgcgcg  cggccgccg  ggcggccgg  gggggcagg  ccccgcgag  ggggccccg  3180
ggacccggg  ggccggcgg  ggcgcggac  ctggacgcg  gccgggccc  tcccgtgga  3240
cgccccagc  gcggcgggc  tcgcggccg  ccccgggga  cccggcggc  gcgcggcgc  3300
ccccccacc  ccaccccac  tctcggtcg  gcgcgcgtc  gctgggggc  ggagcggtc  3360
ggcggcggc  gtcggcggg  ggcggggcg  ggcggttcg  ccccccgcc  taccccccc  3420
gccccgtcc  ccccccgtt  ccccctcct  ctcggcgcg  ggcggcggc  gcggcaggc  3480
gcggagggg  cgcgggccg  tcccccccg  cgggtccgc  cccggggcc  cggttccgc  3540
cgcgcctcg  ctcggccgg  gcctagcag  cgacttaga  ctggtgcgg  ccaggggaa  3600
ccgactgtt  aattaaaac  aagcatcgc  aaggcccgc  gcgggtgtt  acgcgatgt  3660
atttctgcc  agtgctctg  atgtcaaag  gaagaaatt  aatgaagcg  gggtaaacg  3720
cgggagtaa  tatgactct  ttaaggtag  caaatgcct  gtcatctaa  tagtgacgc  3780
catgaatgg  tgaacgaga  tcccactgt  cctacctac  atccagcga  accacagcc  3840
agggaacgg  cttggcgga  tcagcgggg  aagaagacc  tgttgagct  gactctagt  3900
tggcacggt  aagagacat  agaggtgta  aataagtgg  aggcccccg  cgccccccc  3960
gtgtccccg  gaggggccc  gggcggggt  cgcggccct  cgggccgcc  gtgaaatac  4020
actactctg  tcgtttttt  actgacccg  tgaggcggg  gggcgagcc  gaggggctc  4080
cgcttctgg  gccaagcgc  cgcccggcc  ggcgcgacc  gctccgggg  cagtgccag  4140
tggggagtt  gactggggc  gtacacctg  caaacggta  cgcaggtgt  ctaaggcga  4200
ctcagggag  acagaaacc  cccgtggag  agaagggca  aagctcgct  gatcttgat  4260
ttcagtacg  atacagacc  tgaaagcgg  gcctcacga  ccttctgac  ttttgggtt  4320
taagcagga  gtgtcagaa  agttaccac  gggataact  gcttgtggc  gccaagcgt  4380
catagcgac  tcgcttttt  atccttcga  gtcggctct  cctatcatt  tgaagcaga  4440
ttcgccaag  gttggattg  tcacccact  atagggaac  tgagctggg  ttagaccgt  4500
gtgagacag  ttagtttta  cctactgat  atgtgttgt  gccatggta  tcctgctca  4560
tacgagagg  accgcaggt  cagacattt  gtgtatgtg  ttggctgag  agccaatgg  4620
gcgaagcta  catctgtgg  attatgact  aacgcctct  agtcagaat  ccgcccagg  4680
gaacgatac  gcagcgccg  ggagcctcg  ttggcctcg  atagccggt  ccccgcctg  4740
ccccgccgg  gggccgccc  cccctccac  cgccccgcc  cgggagggc  cgtgccccg  4800
cgcgcgccg  gaccggggt  cggtgcgga  tgcccttcg  cctgggaaa  ggggcgcgg  4860
cggaaaggc  gccgccccc  cgcccgtca  gcaccgcac  ttcgtgggg  acctggcgc  4920
aaaccattc  tagacgacc  gcttctggg  cggggtttc  tacgtagca  agcagctcc  4980
tcgctgcga  ctattgaaa  tcagccctc  acacaaggg  ttgtc  5025



<210> 6138
<211> 417
<212> DNA
<213> Rattus norvegicus
<308> AA893870
<400> 6138

cctactcag  ctttattca  agaccaaga  gtataggtg  aagggaggg  agaagggcc  60
ggtcagaag  caagcccgg  aggaggcgg  ttaaaaccc  aaaggtcag  aggatcgtg  120
ggccccgct  tcacggtct  tattcgtac  gaaaatcaa  atcaagcga  cttttgccc  180
tctgctcca  gggaggttt  tgtcctccc  gagctcgcc  taggacacc  gcgttaccg  240
ttgacaggt  taccgcccc  gtcaaactc  ccacctggc  ctgtccccg  agcgggtcg  300
gcccgcccg  acgcgcgga  gggcgcttg  agccagaag  gagagcccc  cggggctcg  360
ccccccgcc  caccgggtc  gtgaaaaaa  gatgagagt  gtggtattt  accggcg  417



<210> 6139
<211> 5025
<212> DNA
<213> Homo sapiens
<308> M11167
<400> 6139

cgcgacctc  gatcagacg  ggcgacccg  tgaatttaa  catattagt  agcggagga  60
aagaaacta  ccaggattc  ctcagtaac  gcgagtgaa  agggaagag  ccagcgccg  120
atccccgcc  cgcggggcg  gggacatgt  gcgtacgga  gacccgctc  ccggcgccg  180
tcgtggggg  cccaagtcc  tctgatcga  gcccagccc  tggacggtg  gaggccggt  240
gcggccggc  cgcgcccgg  tcttcccgg  gtcgggttg  ttgggaatg  agcccaaag  300
gggtggtaa  ctccatcta  ggctaaata  cggcacgag  ccgatagtc  acaagtacc  360
taagggaaa  ttgaaaaga  ctttgaaga  agagttcaa  agggcgtga  accgttaag  420
ggtaaacgg  tggggtccg  gcagtccgc  cggaggatt  aacccggcg  cgggtccgg  480
cgtgtcggc  gcccggcgg  tctttcccg  cccccgttc  tcccgaccc  tccacccgc  540
ctcccttcc  ccgccgccc  tcctcctcc  ccccggagg  ggcgggctc  ggcgggtgc  600
ggggtgggc  ggcggggcc  ggggtgggg  cggcggggg  ccgtccccc  gaccggcga  660
cggccgccg  cgggcgcat  tccaggcgg  gcgccgcga  cggctccgg  acggctggg  720
aggcccggc  gggaaggtg  ctcgggggg  cccgtccgt  cgtccgtcc  cctcctccc  780
cgtctccgc  ccccggccc  gcgtcctcc  tcgggaggg  gcgcgggtc  gggcggcgg  840
ggcggcggc  gtggcggcg  cggcggggg  ggcgggacc  aaacccccc  cgagtgtta  900
agccccccc  gcagcagca  tcgccgaat  ccggggccg  gggagcgag  cccgtcgcc  960
cgctctccc  cctcccggc  cccaccccc  cgggaatcc  cgcgagggg  gtctccccc  1020
gcgcggcgc  ggcgtctcc  cgtgggggg  ccgggccac  cctcccacg  cgcgaccgc  1080
ctcccaccc  tcctccccg  gcccccgcc  cggcgacgg  gggggtgcc  cgcgcgggt  1140
ggggggcgg  gcggactgt  cccagtgcg  cccgggcgg  tcgcgccgt  gggcccggg  1200
gaggttctc  cggggccac  cgcgcgtcc  ccgaagagg  ggacggcgg  gcgagcgca  1260
ggggtcggc  gcgacgtcg  ctacccacc  gacccgtct  gaaacacgg  ccaaggagt  1320
taacacgtg  gcgagtcgg  ggctcgcac  aaagccgcc  tggcgcaat  aaggtgaag  1380
ccggcgcgc  cgccggccg  ggtgggatc  cgaggcctc  ccagtccgc  gaggggcac  1440
accggcccg  ctcgcccgc  gcgccgggg  ggtggagca  gagcgcacg  gttaggacc  1500
gaaagatgg  gaactatgc  tgggcaggg  gaagccaga  gaaactctg  tggaggtcc  1560
tagcggtcc  gacgtgcaa  tcggtcgtc  gacctgggt  taggggcga  agactaatc  1620
aaccatcta  tagctggtt  cctccgaag  ttccctcag  atagctggc  ctctcgcag  1680
cccgacgca  ccccgccac  cagttttat  cggtaaagc  aatgattag  ggtcttggg  1740
ccgaaacga  ctcaaccta  tctcaaact  taaatgggt  agaagcccg  ctcgctggc  1800
tggagccgg  gtggaatgc  agtgcctag  gggccactt  tggtaagca  aactggcgc  1860
gcgggatga  ccgaacgcc  ggttaaggc  cccgatgcc  acgctcatc  gaccccaga  1920
aaggtgttg  ttgatatag  cagcaggac  gtggccatg  aagtcggaa  ccgctaagg  1980
gtgtgtaac  actcacctg  cgaatcaac  agccctgaa  atggatggc  ctggagcgt  2040
gggcccata  ccggccgtc  ccggcagtc  agagtggac  ggagcggcg  gggcggcgg  2100
gcgcgcgcg  gtgtggtgt  cgtcggagg  cggcggcgg  ggcggcggc  ggggtgtgg  2160
gtccttccc  cgccccccc  cccacgcct  ctcccctcc  cccgcccac  ccccgctcc  2220
cgcccccgg  gccccgcgg  gctacgccg  gacgagtag  agggccgct  cggtgagcc  2280
tgaagccta  ggcgcgggc  cgggtggag  ccgccgcag  tgcagatct  ggtggtagt  2340
gcaaatatt  aaacgagaa  tttgaaggc  gaagtggag  agggttcca  gtgaacagc  2400
gttgaacat  ggtcagtcg  tcctgagag  tgggcgagc  ccgttccga  gggacgggc  2460
atggcctcc  ttgccctcg  ccgatcgaa  gggagtcgg  ttcagatcc  cgaatccgg  2520
gtggcggag  tgggcgccg  gaggcgtcc  gtgcggtaa  gcgaccgat  ccggagaag  2580
cggcgggag  cccggggag  gttctcttt  ctttgtgaa  ggcagggcg  cctggaatg  2640
gttcgcccc  agagagggg  ccgtgcctt  gaaagcgtc  cggttccgg  ggcgtccgg  2700
gagctctcg  tggcccttg  aaatccggg  gagagggtg  aaatctcgc  ccgggccgt  2760
cccatatcc  cagcaggtc  ccaaggtga  cagcctctg  catgttgga  caatgtagg  2820
aagggaagt  ggcaagccg  atccgtaac  tcgggataa  gattggctc  aagggctgg  2880
tcggtcggg  tggggcgcg  agcggggct  ggcgcgcgc  gcggctgga  gaggcgcgc  2940
cccccccca  gcccggggc  cccccctcg  ggccctccc  cgccccacc  gcgcgcgcc  3000
ctcgctccc  ccccacccc  cgccctctc  ctctctctc  cccccgctc  ccgtcctcc  3060
ccctccccg  gggagcgcc  cgtgggggc  cggcggggg  agaagggtc  gggcggcag  3120
ggccgcgcg  cggccgccg  ggcggccgg  gggggcagg  ccccgcgag  ggggccccg  3180
ggacccggg  ggccggcgg  ggcgcggac  ctggacgcg  gccgggccc  tcccgtgga  3240
cgccccagc  gcggcgggc  tcgcggccg  ccccgggga  cccggcggc  gcgcggcgc  3300
ccccccacc  ccaccccac  tctcggtcg  gcgcgcgtc  gctgggggc  ggagcggtc  3360
ggcggcggc  gtcggcggg  ggcggggcg  ggcggttcg  ccccccgcc  taccccccc  3420
gccccgtcc  ccccccgtt  ccccctcct  ctcggcgcg  ggcggcggc  gcggcaggc  3480
gcggagggg  cgcgggccg  tcccccccg  cgggtccgc  cccggggcc  cggttccgc  3540
cgcgcctcg  ctcggccgg  gcctagcag  cgacttaga  ctggtgcgg  ccaggggaa  3600
ccgactgtt  aattaaaac  aagcatcgc  aaggcccgc  gcgggtgtt  acgcgatgt  3660
atttctgcc  agtgctctg  atgtcaaag  gaagaaatt  aatgaagcg  gggtaaacg  3720
cgggagtaa  tatgactct  ttaaggtag  caaatgcct  gtcatctaa  tagtgacgc  3780
catgaatgg  tgaacgaga  tcccactgt  cctacctac  atccagcga  accacagcc  3840
agggaacgg  cttggcgga  tcagcgggg  aagaagacc  tgttgagct  gactctagt  3900
tggcacggt  aagagacat  agaggtgta  aataagtgg  aggcccccg  cgccccccc  3960
gtgtccccg  gaggggccc  gggcggggt  cgcggccct  cgggccgcc  gtgaaatac  4020
actactctg  tcgtttttt  actgacccg  tgaggcggg  gggcgagcc  gaggggctc  4080
cgcttctgg  gccaagcgc  cgcccggcc  ggcgcgacc  gctccgggg  cagtgccag  4140
tggggagtt  gactggggc  gtacacctg  caaacggta  cgcaggtgt  ctaaggcga  4200
ctcagggag  acagaaacc  cccgtggag  agaagggca  aagctcgct  gatcttgat  4260
ttcagtacg  atacagacc  tgaaagcgg  gcctcacga  ccttctgac  ttttgggtt  4320
taagcagga  gtgtcagaa  agttaccac  gggataact  gcttgtggc  gccaagcgt  4380
catagcgac  tcgcttttt  atccttcga  gtcggctct  cctatcatt  tgaagcaga  4440
ttcgccaag  gttggattg  tcacccact  atagggaac  tgagctggg  ttagaccgt  4500
gtgagacag  ttagtttta  cctactgat  atgtgttgt  gccatggta  tcctgctca  4560
tacgagagg  accgcaggt  cagacattt  gtgtatgtg  ttggctgag  agccaatgg  4620
gcgaagcta  catctgtgg  attatgact  aacgcctct  agtcagaat  ccgcccagg  4680
gaacgatac  gcagcgccg  ggagcctcg  ttggcctcg  atagccggt  ccccgcctg  4740
ccccgccgg  gggccgccc  cccctccac  cgccccgcc  cgggagggc  cgtgccccg  4800
cgcgcgccg  gaccggggt  cggtgcgga  tgcccttcg  cctgggaaa  ggggcgcgg  4860
cggaaaggc  gccgccccc  cgcccgtca  gcaccgcac  ttcgtgggg  acctggcgc  4920
aaaccattc  tagacgacc  gcttctggg  cggggtttc  tacgtagca  agcagctcc  4980
tcgctgcga  ctattgaaa  tcagccctc  acacaaggg  ttgtc  5025



<210> 6140
<211> 510
<212> DNA
<213> Rattus norvegicus
<308> AA893871
<400> 6140

gaaaaacca  aatacttta  tgcaacaag  acaaaagaa  cacatgcgt  acaaaagca  60
ccatataac  ttatattcc  aataaaaca  ctaaagctt  gcattataa  tccagcagc  120
aatataagt  actatttaa  aaacattcc  aaagaatta  aagtcaaca  aaaaaaggt  180
atcattaag  tttccaaac  cctttaatt  aattggttt  ctataaagt  cacatgaaa  240
gagtcacaa  tctaaaact  caaggatca  ttgctaccc  gctcatccc  ttctcagtt  300
gtttatgtt  agggacaca  tcaatctag  ggagtcttt  aattcaatc  aggggccta  360
agagaaaga  gcagctgat  aaaataact  ttatagtat  aagatgcta  ttaaataaa  420
gagaggaat  ggctataca  cttaagagg  cttcaggtt  atcctaaac  ctgtgcctc  480
cactagcat  tactaagct  atgttgaatg  510



<210> 6141
<211> 453
<212> DNA
<213> Rattus norvegicus
<308> AA893924
<400> 6141

gccctcggg  cggggttca  gtccttccc  cggctcgtg  acgactgcg  ggctggaca  60
ggacacgag  cactcggcg  caaagtggt  cacataggc  gcggctgcc  tgctgcggg  120
tcgggcgcg  ggtgctctc  caggagtcg  cagcggcgc  tccgcaccc  cggcctccg  180
agagcggcg  ggggcgggg  cgcggcgcg  cctcttctc  ggctgggct  ggctaggct  240
ggcgcgtag  cgcttctgc  gtcacccgc  cggctccgc  tcctcctgg  cgggcactg  300
agggtgagc  catgggggg  tccagtgag  tgggtccgc  tgcggcgtc  gaaccggcc  360
gtcctacgg  cgtcgagcg  cggcgacgt  aggcacgac  cctgcaagt  gcggtcgca  420
ttccaccgt  cattgtggc  agcgggaca  cct  453



<210> 6142
<211> 289
<212> PRT
<213> Rattus norvegicus
<308> AAF73964
<400> 6142

Met Ala Ala Ala Ala Tyr Val Asp His Phe Ala Ala Glu Cys Leu Val 
  1               5                  10                  15
Ser Met Ser Ser Arg Ala Val Val His Glu Pro Arg Glu Gly Pro Glu 
             20                  25                  30
Pro Arg Pro Glu Gly Ala Ala Ala Ala Ala Pro Thr Leu Pro Arg Val 
         35                  40                  45
Asp Glu Arg Arg Asp Gly Lys Asp Ser Ala Ser Leu Phe Val Val Ala 
     50                  55                  60
Arg Ile Leu Ala Asp Leu Asn Gln Gln Ala Pro Ala Pro Ala Pro Ala 
 65                  70                  75                  80
Glu Arg Arg Glu Gly Ala Ala Ala Arg Lys Ala Arg Thr Pro Cys Arg 
                 85                  90                  95
Leu Pro Pro Ala Pro Pro Ala Pro Pro Pro Gly Pro Glu Pro Ala Ser 
             100                105                110
Pro Gly Gln Ala Gly Ala Pro Ala Ala Pro Pro Ser Pro Ala Trp Ser 
         115                120                125
Glu Pro Glu Ala Ala Leu Glu Gln Glu Pro Gly Pro Ala Gly Ser Gly 
     130                135                140
Glu Pro Gly Leu Arg Gln Arg Gly Arg Arg Gly Arg Ser Arg Ala Asp 
 145                150                155                160
Leu Glu Ser Pro Gln Arg Lys His Lys Cys His Tyr Ala Gly Cys Glu 
                 165                170                175
Lys Val Tyr Gly Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His 
             180                185                190
Thr Gly Glu Arg Pro Phe Ala Cys Ser Trp Gln Glu Cys Asn Lys Lys 
         195                200                205
Phe Ala Arg Ser Asp Glu Leu Ala Arg His Tyr Arg Thr His Thr Gly 
     210                215                220
Glu Lys Lys Phe Ser Cys Pro Ile Cys Glu Lys Arg Phe Met Arg Ser 
 225                230                235                240
Asp His Leu Thr Lys His Ala Arg Arg His Ala Asn Phe His Pro Gly 
                 245                250                255
Met Leu Gln Arg Arg Gly Gly Gly Ser Arg Thr Gly Ser Leu Ser Asp 
             260                265                270
Tyr Ser Arg Ser Asp Ala Ser Ser Pro Thr Ile Ser Pro Ala Ser Ser 
         275                280                285
Pro 
     290



<210> 6143
<211> 1360
<212> DNA
<213> Homo sapiens
<308> BC013946
<400> 6143

ggcacgagg  gacttggcg  ggtggtccc  aacgttgcc  ctcggcatc  ttagaaccg  60
ccgcccctg  cgccgcgcg  ggaccccag  cgcccgcgc  ccccatgcg  tcactcttc  120
gtgcccggc  gggccggcg  ctcgcagac  cggagccgc  cgggtgacg  cacaggcgg  180
tgcgcgccc  gcccagccc  gcccagccc  aggagaggg  gcgccgcgc  cccgccccc  240
gcccgctct  ccgaggccg  gggtgcgga  gcgcggctg  cgactcgca  caagagcac  300
gccgccggc  ccagcccgc  gcatggcag  cgccgccta  gtggaccac  tcgccgccg  360
gtgcctcgt  tccatgtcg  gccgcgcgg  cgtgcacgg  ccgcgggag  ggccggagt  420
ccggcccga  ggcgcggcc  tggccgcca  ccccacgct  ccccgcgtc  aggagcgcc  480
cgacggtaa  gacagcgcc  cgctcttcg  ggtggcgcg  atcctagcg  acctcaacc  540
gcaagcgcc  gcgcccgcc  cggcggagc  cagggaggg  gccgcggcc  ggaaggcga  600
gaccccctg  cgcctgccg  cgcccgccc  cgagcccac  tcccccggc  ccgaaggcg  660
ggcggccgc  ccccccagc  cggcgtgga  cgagccgga  cccgaggcg  ggctggagc  720
cgagcggga  ccggggccc  cggggagcg  cgagcccgg  ctcagacaa  gggtccggc  780
gggccgaag  cgcgccgac  tcgagtccc  gcagaggaa  cacaagtgc  actacgcgg  840
ctgcgagaa  gtttacggg  aatcttcgc  cctcaaggc  cacctgaga  ctcacacag  900
tgagaggcc  ttcgcctgc  gctggcagg  ctgcaacaa  aagttcgcg  gctccgacg  960
gctggcgcg  cactaccgc  cacacacgg  cgagaagaa  ttcagctgc  ccatctgcg  1020
gaagcgctt  atgcgcagc  accacctga  caagcacgc  cgccgccac  ccaacttcc  1080
cccgggaat  ctgcagcgg  gcggcgggg  ctcgcggac  ggctccctc  gcgactaca  1140
ccgctccga  gccagcagc  ccaccatca  cccggccag  tcgccctga  cccgccaca  1200
ccatgagca  ccgctccca  cccctcgtg  gtccctggc  tttcctttt  taataagaa  1260
gaagagaga  aacttgatg  aaagtccac  aaaaaacaa  ttttttcac  tcaggtgtc  1320
aagtaaatt  gttaaaaaa  aaaaaaaaa  aaaaaaaaaa  1360



<210> 6144
<211> 288
<212> PRT
<213> Homo sapiens
<308> Q9Y2Y9
<400> 6144

Met Ala Ala Ala Ala Tyr Val Asp His Phe Ala Ala Glu Cys Leu Val 
  1               5                  10                  15
Ser Met Ser Ser Arg Ala Val Val His Gly Pro Arg Glu Gly Pro Glu 
             20                  25                  30
Ser Arg Pro Glu Gly Ala Ala Val Ala Ala Thr Pro Thr Leu Pro Arg 
         35                  40                  45
Val Glu Glu Arg Arg Asp Gly Lys Asp Ser Ala Ser Leu Phe Val Val 
     50                  55                  60
Ala Arg Ile Leu Ala Asp Leu Asn Gln Gln Ala Pro Ala Pro Ala Pro 
 65                  70                  75                  80
Ala Glu Arg Arg Glu Gly Ala Ala Ala Arg Lys Ala Arg Thr Pro Cys 
                 85                  90                  95
Arg Leu Pro Pro Pro Ala Pro Glu Pro Thr Ser Pro Gly Ala Glu Gly 
             100                105                110
Ala Ala Ala Ala Pro Pro Ser Pro Ala Trp Ser Glu Pro Glu Pro Glu 
         115                120                125
Ala Gly Leu Glu Pro Glu Arg Glu Pro Gly Pro Ala Gly Ser Gly Glu 
     130                135                140
Pro Gly Leu Arg Gln Arg Val Arg Arg Gly Arg Ser Arg Ala Asp Leu 
 145                150                155                160
Glu Ser Pro Gln Arg Lys His Lys Cys His Tyr Ala Gly Cys Glu Lys 
                 165                170                175
Val Tyr Gly Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr 
             180                185                190
Gly Glu Arg Pro Phe Ala Cys Ser Trp Gln Asp Cys Asn Lys Lys Phe 
         195                200                205
Ala Arg Ser Asp Glu Leu Ala Arg His Tyr Arg Thr His Thr Gly Glu 
     210                215                220
Lys Lys Phe Ser Cys Pro Ile Cys Glu Lys Arg Phe Met Arg Ser Asp 
 225                230                235                240
His Leu Thr Lys His Ala Arg Arg His Ala Asn Phe His Pro Gly Met 
                 245                250                255
Leu Gln Arg Arg Gly Gly Gly Ser Arg Thr Gly Ser Leu Ser Asp Tyr 
             260                265                270
Ser Arg Ser Asp Ala Ser Ser Pro Thr Ile Ser Pro Ala Ser Ser Pro 
         275                280                285



<210> 6145
<211> 416
<212> DNA
<213> Rattus norvegicus
<308> AA893939
<400> 6145

acaaacaaa  ataaatccc  gagataatg  aataaacat  ttctctaaa  tatcccatg  60
tggtttctc  gtccgagaa  gtggtagag  ccatgttta  gttcctgga  cattcctgg  120
tgctatgaa  tctccatct  gtaaccatg  ttctccagc  cagcgcgta  ctgattgga  180
aagtcgtct  ctacattgt  atcatccca  ttatcctcc  agacatgtg  atcttcatc  240
tcatctaag  cggcccagt  ttccgcggg  aactcctcg  actcgtcgt  ctcttcacc  300
cattctgga  aacaacaaa  gaaacaaca  gtcacatat  ttacggacc  tttcctcac  360
atcaaaaac  tctggattc  cctcagcca  ttacaggct  gatgctctt  ctgttt  416



<210> 6146
<211> 70
<212> PRT
<213> Rattus norvegicus
<308> NP_033195
<400> 6146

Met Ser Glu Lys Lys Gln Pro Val Asp Leu Gly Leu Leu Glu Glu Asp 
  1               5                  10                  15
Asp Glu Phe Glu Glu Phe Pro Ala Glu Asp Trp Ala Gly Leu Asp Glu 
             20                  25                  30
Asp Glu Asp Ala His Val Trp Glu Asp Asn Trp Asp Asp Asp Asn Val 
         35                  40                  45
Glu Asp Asp Phe Ser Asn Gln Leu Arg Ala Glu Leu Glu Lys His Gly 
     50                  55                  60
Tyr Lys Met Glu Thr Ser 
 65                  70



<210> 6147
<211> 421
<212> DNA
<213> Rattus norvegicus
<308> AA893946
<400> 6147

aaaaaaatc  atttattgt  aatagagac  tgcactcat  ctctccgtg  ttccaggca  60
ccacaggga  gtctggcag  tgtgtgggt  ctccatagg  tgggtaatg  ggctgagag  120
ccctggtta  agaactaag  tagagcaaa  cagctatgg  tatttggtg  tgcctgaag  180
gcagctcct  ggcatgggg  gcacgtcta  aggctccac  ggacacatt  ccactggat  240
caacataaa  gaacctctg  ggtcggggg  acatgtgtt  atcctgaaa  ccttccggc  300
ggccaagac  tcaccctga  agctgtaca  ggggttgct  ctcttttcc  cttcatcag  360
ggccaccan  gccatgggc  caaggggaa  gataagcag  tcactggat  cctggtcat  420
t  421



<210> 6148
<211> 421
<212> DNA
<213> Rattus norvegicus
<308> AA893946
<400> 6148

aaaaaaatc  atttattgt  aatagagac  tgcactcat  ctctccgtg  ttccaggca  60
ccacaggga  gtctggcag  tgtgtgggt  ctccatagg  tgggtaatg  ggctgagag  120
ccctggtta  agaactaag  tagagcaaa  cagctatgg  tatttggtg  tgcctgaag  180
gcagctcct  ggcatgggg  gcacgtcta  aggctccac  ggacacatt  ccactggat  240
caacataaa  gaacctctg  ggtcggggg  acatgtgtt  atcctgaaa  ccttccggc  300
ggccaagac  tcaccctga  agctgtaca  ggggttgct  ctcttttcc  cttcatcag  360
ggccaccan  gccatgggc  caaggggaa  gataagcag  tcactggat  cctggtcat  420
t  421



<210> 6149
<211> 520
<212> DNA
<213> Rattus norvegicus
<308> AA893970
<400> 6149

aacaatgaa  ccctttgat  agattatgc  tcaggaggc  ttaatgccc  taacataaa  60
tgtacacat  atacaaaaa  attacaacc  caataacag  aacaacaac  aaaatcaaa  120
tgagcaaaa  catttgggg  caaatctta  ttaaattat  cacaactca  tgaaatatt  180
ttaaggaaa  tatataaat  ctttttctt  ctatgttac  gttatacaa  ataaatcag  240
tttcaatgt  tgttcagtg  cctacaaat  ccagaacct  caaaaatgt  gcagcgtat  300
actaaataa  aacacgtta  gtggtcgga  agcattagc  gagatcctc  ctatgatcc  360
ttaccactc  tcaaagcta  ctgaactta  atcatttgt  tcacaatgc  tccttaggg  420
ttctgacag  ccagcaatg  aacattttt  aacaatcat  cattaaaaa  ttttaccac  480
cccgctctg  cccaagact  cattttgtg  tacatcaact  520



<210> 6150
<211> 1579
<212> DNA
<213> Homo sapiens
<308> AK024327
<400> 6150

tatactttt  tttcctgtt  attcttagg  agattggaa  ggggaaaca  tctgttctc  60
ctaattaaa  tttttctaa  aacgattag  agaatatgg  cattctata  gacagtgac  120
ttaaaagag  ctctttgga  gtatataca  tattaacat  atgtgtaca  gtccttttg  180
aatgacaac  ttaatgggt  tcagctctt  tatctagag  ttgagataa  tcaagctga  240
tttttcagg  catatcaca  cggcaaagt  ttcagcagt  ggatatcaa  gcttattta  300
attttccta  tgctattta  ataaaatgt  attccattc  gaggatgcc  tttatcccc  360
cattaaagc  cagatcatt  agcaataaa  accaaattg  ctgtcattc  aattataac  420
gcagttatt  ttgcatggt  agagtgagg  gctaatttt  tgtgagatg  actttgtaa  480
ctactttgg  aaatgttct  tggaagtaa  gttttttct  ctttagtct  atgcttcca  540
ttttgtctc  gattcacaa  ccattaaaa  atggggaaa  aagaaaagg  aaaattgag  600
gacttttgt  agaggagct  tttggaatg  accaacatt  cagattttc  aaaatgtaa  660
ttaggaagt  tccattgtc  ctgcattaa  aaaatacac  gttactatc  taatctcaa  720
agtgtcatt  cagtgagaa  ctcatttaa  agcatacca  tgaaattaa  agcagtgct  780
atcaaagaa  actgaaatc  gtgagaatc  ttctaggag  attcttttc  tcttttagt  840
ccaagttcc  gggtatttt  cattcctag  aggtttata  gactcacag  atgtggact  900
ttttcctgt  tggagtatt  ttgtaatgt  agtatcgga  agctgcacc  cagcatgca  960
aaattgcac  ttttgtttt  ctttcttta  agaatattt  atttcaaaa  tataattta  1020
gccaaaaaa  gcatacctt  caattttgc  acttggttg  tttagcaca  aatgcaaag  1080
cttggggca  agaggggga  tgaaaaaaa  tttataggt  attgttaca  aaatacctg  1140
cagaaaccc  aaagctgca  tgtaaaaca  atggtgtaa  ctagttttg  aaagtggta  1200
ggaattgtg  aaaaaatct  agacttaat  ctctctaac  acatgagtt  cttcttttt  1260
atttagtaa  acgctgcta  atatttgga  gttctggtg  ttgtaggtc  ctgaacaga  1320
attgaaatc  gatttatat  gtataactg  aacatagaa  gaaaaagta  ttatatttt  1380
tctgtaaga  tatttcatt  agttgtgta  aatttaaat  agatttgtc  ccaaatggt  1440
ttgctcacc  tgatttttt  tgttgtgat  ttcttgttt  tgtataatg  gtatagttt  1500
tgtcaaggg  attaaaagc  tcctgaagc  taatcttat  aaagggata  attgttaat  1560
aaatgtact  aaaattctt  1579



<210> 6151
<211> 484
<212> DNA
<213> Rattus norvegicus
<308> AA893980
<400> 6151

aaaataact  catccttta  tggcagtaa  acaattact  gattaagag  ccacatgag  60
aggcaggtg  ggtttctgg  agacagata  tgagtacaa  aggggcggg  gagccatgc  120
acgatcatt  taaaaatac  gtacgttat  tacatattt  caccatcga  tttcaactc  180
gaaatacta  ttacacgtt  gttacaatc  tggttagag  acaatcttt  tttacgagt  240
tggcctgac  gcaagtggg  attcaagcg  atgtccttg  tccatgagg  ccttcagtt  300
actgttccg  aggaaggct  cagactcca  ctcacccac  gatttcagc  ttaaaaatt  360
atttaattt  ttctttagc  aaaggacag  ttttttcta  tatagacca  gctggcttt  420
aacctgtga  cctcctgcc  ctcctcctg  gtgccggga  gacaggcgc  ctaccaagc  480
tggc  484



<210> 6152
<211> 3174
<212> DNA
<213> Homo sapiens
<308> AL050155
<400> 6152

aggacgcag  gccccccgt  cccgcggcc  tgcaatcca  gcccaccct  gacccccgg  60
tgcaccgcg  tgccacggc  gggcccccc  acgcccggc  gcgcccggg  gcctccacg  120
attccagca  acagggcgc  aacctcccc  actttgaac  tctgtctcg  atcctcaag  180
cagtcaatg  caccggctc  tcggccgcc  ccggttcca  cgacaaacc  agtgacccc  240
gggtgcgga  ggcccccac  gaccctcgg  tgcagaaac  cacagactc  acggcctcc  300
cccgggctg  caagcccgg  cctgctgag  cgccctctc  caccgccag  ccgagtggg  360
atgcctccc  accagccac  gctccctac  acccccgcg  gctggcggc  ggtggactg  420
gccagggcg  agggggcgg  cagagcagt  tgctgagcg  tatcagcct  tacgacccg  480
ggactccca  cgcgggggg  aaagccaca  agccggctg  tgacacggg  gcccagccc  540
agggtgctg  gggcaatgg  aagagctcg  cctccaagg  taaggagcc  ccgttcgtc  600
gcaagtctg  cctggaaca  ccagagaca  ggaaggccg  tgctgatgg  ggcaccccc  660
cggacagat  caacagcta  aaccggccc  ggcccaagg  tgctgcagc  cccgctgcc  720
ccaccgcca  cccaccccc  gagggtgcc  caccccagc  cggggtgca  aacctgccc  780
tgcccaccc  cttcgggac  gtgaagcag  cacccaaga  gggctcagg  agcccattt  840
ctgggaaca  tccggcccg  gagggtgag  aggatgcgg  atccctgaa  gatgttttt  900
aaggcttcg  ccccacggc  tcccccttt  gccagtagt  tccagccag  gctgcggct  960
cagccaccc  tcctagggt  gcattcagg  cagcaccca  ggtagggaa  ttgggggca  1020
ggggaggca  gctgggtgt  ccttttttc  tttcttttt  ttttgcttt  cgtctcttt  1080
atttttttt  aaagtagta  tttctttga  atttgtaaa  tgtatataa  catcttaag  1140
tctggtcag  gtggcgggc  caggggctc  tgctgagca  accgactca  gcccgcaaa  1200
ctgtgaact  tcgccagtg  ctggcctca  actctgtgg  ctctgcgtg  ccgggcctt  1260
ctggaggcc  agtgggttt  ctgggcaaa  catggcccc  tttccccag  acaaaggga  1320
cagttggtg  ctgggaagg  attgaacgc  cctcaccct  tgcccgaag  gacccggaa  1380
caagaccat  gcagggcct  cgtggaagc  ggtccaggc  tttctagaa  cctagggtg  1440
accatcact  tcttttcag  gcaggctgt  acagcccac  caggagaca  tgagagtga  1500
aaggtatta  ggaaaaagc  cccagcggc  ctatggggg  tccctggtg  atgcctgct  1560
ctgtccctg  attaccaca  gtgccctcc  tgccaccct  cgtctagag  aagcggatg  1620
cccccagcc  gcagcagaa  cctccacag  gagaactgg  cccaaaggt  gtgggggcc  1680
gtgtggggc  gagtcctga  gagccacct  taggaggca  cccctagga  cacgcacgt  1740
ctgtcagta  taccccacc  gtcctatca  gtgggccac  ccctgcttg  ccacaccag  1800
gtctgtcct  gtcctcaag  cacgcaccc  ctatgcctg  actgcagcc  agccccgga  1860
agctccagg  tccgtgcag  ggctgcgcc  ccaggcccc  acaatgggg  ccctggggt  1920
gctcctggc  aagtgttct  tgttttcct  gcacctcct  acactgtgt  acctgcagg  1980
catgaggta  tgatgtgtt  gggtttcct  tcccaagcc  gcagatgca  gtgttccaa  2040
gtgtgttgc  ctgtgggat  tgtggacac  taagaaacg  actgagtgg  aaccctgca  2100
ccaggggat  gggagcctc  gctcccccc  tgctcccac  ctggctgag  gccagcctc  2160
tctgcagag  cctggagga  gcccaccta  ggacacagc  cgagagatg  gcgcaaggg  2220
tgctggggg  ggcctgcta  cctgcctct  ggccacttg  ggggcctca  gaagtgtgt  2280
cttgtggct  catctgccc  tctccctgg  ccaccatgt  gctgcaggc  aagctcttc  2340
ttgctgacc  tgaagagac  tagttacct  ccaagggat  ccccttccc  cctcctcag  2400
gtggggtga  caaggctcc  atcccaccc  accccaaaa  gagaaaaat  aaaaactca  2460
agtttggag  caggaggca  ggtgtccta  agggctgca  agccctgag  ggtcagtgc  2520
gggatctgg  tggttggtt  gtctttttg  ctttttttt  ttttttttt  ttttacaca  2580
tcattaatg  gatttgtct  cagccacca  tgttggcct  gaagcagag  gcacagccc  2640
tggtgtttg  aaaataagt  tgaatacac  gtgtggcag  gttgtggtt  ttgttgttg  2700
ttttcctct  cttttgaga  ttttctttt  taaaagaaa  atatttttt  aaccgaaat  2760
tgtggatga  atagaagct  gagccctcc  cttggaata  tcagcctaa  aacctcata  2820
gactatgaa  tcacccgaa  ttctcattt  ccatcaggc  gagctttta  agaaaaatt  2880
ttctctaac  aggattgta  caaaagtgt  aatactgtt  cagagttga  agttggtgg  2940
gcaaatatg  atataatga  ctgtatttt  acaatgatc  ccgcatgac  atttcacac  3000
ctttttata  tccatatct  tcttccaga  acgtcacct  cctttctcc  gtggtctct  3060
aatccagta  ttgtattac  gccattaaa  gatgcagtt  ttttaaaaa  aaaaaaaaa  3120
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaa  3174



<210> 6153
<211> 484
<212> DNA
<213> Rattus norvegicus
<308> AA893980
<400> 6153

aaaataact  catccttta  tggcagtaa  acaattact  gattaagag  ccacatgag  60
aggcaggtg  ggtttctgg  agacagata  tgagtacaa  aggggcggg  gagccatgc  120
acgatcatt  taaaaatac  gtacgttat  tacatattt  caccatcga  tttcaactc  180
gaaatacta  ttacacgtt  gttacaatc  tggttagag  acaatcttt  tttacgagt  240
tggcctgac  gcaagtggg  attcaagcg  atgtccttg  tccatgagg  ccttcagtt  300
actgttccg  aggaaggct  cagactcca  ctcacccac  gatttcagc  ttaaaaatt  360
atttaattt  ttctttagc  aaaggacag  ttttttcta  tatagacca  gctggcttt  420
aacctgtga  cctcctgcc  ctcctcctg  gtgccggga  gacaggcgc  ctaccaagc  480
tggc  484



<210> 6154
<211> 3174
<212> DNA
<213> Homo sapiens
<308> AL050155
<400> 6154

aggacgcag  gccccccgt  cccgcggcc  tgcaatcca  gcccaccct  gacccccgg  60
tgcaccgcg  tgccacggc  gggcccccc  acgcccggc  gcgcccggg  gcctccacg  120
attccagca  acagggcgc  aacctcccc  actttgaac  tctgtctcg  atcctcaag  180
cagtcaatg  caccggctc  tcggccgcc  ccggttcca  cgacaaacc  agtgacccc  240
gggtgcgga  ggcccccac  gaccctcgg  tgcagaaac  cacagactc  acggcctcc  300
cccgggctg  caagcccgg  cctgctgag  cgccctctc  caccgccag  ccgagtggg  360
atgcctccc  accagccac  gctccctac  acccccgcg  gctggcggc  ggtggactg  420
gccagggcg  agggggcgg  cagagcagt  tgctgagcg  tatcagcct  tacgacccg  480
ggactccca  cgcgggggg  aaagccaca  agccggctg  tgacacggg  gcccagccc  540
agggtgctg  gggcaatgg  aagagctcg  cctccaagg  taaggagcc  ccgttcgtc  600
gcaagtctg  cctggaaca  ccagagaca  ggaaggccg  tgctgatgg  ggcaccccc  660
cggacagat  caacagcta  aaccggccc  ggcccaagg  tgctgcagc  cccgctgcc  720
ccaccgcca  cccaccccc  gagggtgcc  caccccagc  cggggtgca  aacctgccc  780
tgcccaccc  cttcgggac  gtgaagcag  cacccaaga  gggctcagg  agcccattt  840
ctgggaaca  tccggcccg  gagggtgag  aggatgcgg  atccctgaa  gatgttttt  900
aaggcttcg  ccccacggc  tcccccttt  gccagtagt  tccagccag  gctgcggct  960
cagccaccc  tcctagggt  gcattcagg  cagcaccca  ggtagggaa  ttgggggca  1020
ggggaggca  gctgggtgt  ccttttttc  tttcttttt  ttttgcttt  cgtctcttt  1080
atttttttt  aaagtagta  tttctttga  atttgtaaa  tgtatataa  catcttaag  1140
tctggtcag  gtggcgggc  caggggctc  tgctgagca  accgactca  gcccgcaaa  1200
ctgtgaact  tcgccagtg  ctggcctca  actctgtgg  ctctgcgtg  ccgggcctt  1260
ctggaggcc  agtgggttt  ctgggcaaa  catggcccc  tttccccag  acaaaggga  1320
cagttggtg  ctgggaagg  attgaacgc  cctcaccct  tgcccgaag  gacccggaa  1380
caagaccat  gcagggcct  cgtggaagc  ggtccaggc  tttctagaa  cctagggtg  1440
accatcact  tcttttcag  gcaggctgt  acagcccac  caggagaca  tgagagtga  1500
aaggtatta  ggaaaaagc  cccagcggc  ctatggggg  tccctggtg  atgcctgct  1560
ctgtccctg  attaccaca  gtgccctcc  tgccaccct  cgtctagag  aagcggatg  1620
cccccagcc  gcagcagaa  cctccacag  gagaactgg  cccaaaggt  gtgggggcc  1680
gtgtggggc  gagtcctga  gagccacct  taggaggca  cccctagga  cacgcacgt  1740
ctgtcagta  taccccacc  gtcctatca  gtgggccac  ccctgcttg  ccacaccag  1800
gtctgtcct  gtcctcaag  cacgcaccc  ctatgcctg  actgcagcc  agccccgga  1860
agctccagg  tccgtgcag  ggctgcgcc  ccaggcccc  acaatgggg  ccctggggt  1920
gctcctggc  aagtgttct  tgttttcct  gcacctcct  acactgtgt  acctgcagg  1980
catgaggta  tgatgtgtt  gggtttcct  tcccaagcc  gcagatgca  gtgttccaa  2040
gtgtgttgc  ctgtgggat  tgtggacac  taagaaacg  actgagtgg  aaccctgca  2100
ccaggggat  gggagcctc  gctcccccc  tgctcccac  ctggctgag  gccagcctc  2160
tctgcagag  cctggagga  gcccaccta  ggacacagc  cgagagatg  gcgcaaggg  2220
tgctggggg  ggcctgcta  cctgcctct  ggccacttg  ggggcctca  gaagtgtgt  2280
cttgtggct  catctgccc  tctccctgg  ccaccatgt  gctgcaggc  aagctcttc  2340
ttgctgacc  tgaagagac  tagttacct  ccaagggat  ccccttccc  cctcctcag  2400
gtggggtga  caaggctcc  atcccaccc  accccaaaa  gagaaaaat  aaaaactca  2460
agtttggag  caggaggca  ggtgtccta  agggctgca  agccctgag  ggtcagtgc  2520
gggatctgg  tggttggtt  gtctttttg  ctttttttt  ttttttttt  ttttacaca  2580
tcattaatg  gatttgtct  cagccacca  tgttggcct  gaagcagag  gcacagccc  2640
tggtgtttg  aaaataagt  tgaatacac  gtgtggcag  gttgtggtt  ttgttgttg  2700
ttttcctct  cttttgaga  ttttctttt  taaaagaaa  atatttttt  aaccgaaat  2760
tgtggatga  atagaagct  gagccctcc  cttggaata  tcagcctaa  aacctcata  2820
gactatgaa  tcacccgaa  ttctcattt  ccatcaggc  gagctttta  agaaaaatt  2880
ttctctaac  aggattgta  caaaagtgt  aatactgtt  cagagttga  agttggtgg  2940
gcaaatatg  atataatga  ctgtatttt  acaatgatc  ccgcatgac  atttcacac  3000
ctttttata  tccatatct  tcttccaga  acgtcacct  cctttctcc  gtggtctct  3060
aatccagta  ttgtattac  gccattaaa  gatgcagtt  ttttaaaaa  aaaaaaaaa  3120
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaa  3174



<210> 6155
<211> 484
<212> DNA
<213> Rattus norvegicus
<308> AA893980
<400> 6155

aaaataact  catccttta  tggcagtaa  acaattact  gattaagag  ccacatgag  60
aggcaggtg  ggtttctgg  agacagata  tgagtacaa  aggggcggg  gagccatgc  120
acgatcatt  taaaaatac  gtacgttat  tacatattt  caccatcga  tttcaactc  180
gaaatacta  ttacacgtt  gttacaatc  tggttagag  acaatcttt  tttacgagt  240
tggcctgac  gcaagtggg  attcaagcg  atgtccttg  tccatgagg  ccttcagtt  300
actgttccg  aggaaggct  cagactcca  ctcacccac  gatttcagc  ttaaaaatt  360
atttaattt  ttctttagc  aaaggacag  ttttttcta  tatagacca  gctggcttt  420
aacctgtga  cctcctgcc  ctcctcctg  gtgccggga  gacaggcgc  ctaccaagc  480
tggc  484



<210> 6156
<211> 3174
<212> DNA
<213> Homo sapiens
<308> AL050155
<400> 6156

aggacgcag  gccccccgt  cccgcggcc  tgcaatcca  gcccaccct  gacccccgg  60
tgcaccgcg  tgccacggc  gggcccccc  acgcccggc  gcgcccggg  gcctccacg  120
attccagca  acagggcgc  aacctcccc  actttgaac  tctgtctcg  atcctcaag  180
cagtcaatg  caccggctc  tcggccgcc  ccggttcca  cgacaaacc  agtgacccc  240
gggtgcgga  ggcccccac  gaccctcgg  tgcagaaac  cacagactc  acggcctcc  300
cccgggctg  caagcccgg  cctgctgag  cgccctctc  caccgccag  ccgagtggg  360
atgcctccc  accagccac  gctccctac  acccccgcg  gctggcggc  ggtggactg  420
gccagggcg  agggggcgg  cagagcagt  tgctgagcg  tatcagcct  tacgacccg  480
ggactccca  cgcgggggg  aaagccaca  agccggctg  tgacacggg  gcccagccc  540
agggtgctg  gggcaatgg  aagagctcg  cctccaagg  taaggagcc  ccgttcgtc  600
gcaagtctg  cctggaaca  ccagagaca  ggaaggccg  tgctgatgg  ggcaccccc  660
cggacagat  caacagcta  aaccggccc  ggcccaagg  tgctgcagc  cccgctgcc  720
ccaccgcca  cccaccccc  gagggtgcc  caccccagc  cggggtgca  aacctgccc  780
tgcccaccc  cttcgggac  gtgaagcag  cacccaaga  gggctcagg  agcccattt  840
ctgggaaca  tccggcccg  gagggtgag  aggatgcgg  atccctgaa  gatgttttt  900
aaggcttcg  ccccacggc  tcccccttt  gccagtagt  tccagccag  gctgcggct  960
cagccaccc  tcctagggt  gcattcagg  cagcaccca  ggtagggaa  ttgggggca  1020
ggggaggca  gctgggtgt  ccttttttc  tttcttttt  ttttgcttt  cgtctcttt  1080
atttttttt  aaagtagta  tttctttga  atttgtaaa  tgtatataa  catcttaag  1140
tctggtcag  gtggcgggc  caggggctc  tgctgagca  accgactca  gcccgcaaa  1200
ctgtgaact  tcgccagtg  ctggcctca  actctgtgg  ctctgcgtg  ccgggcctt  1260
ctggaggcc  agtgggttt  ctgggcaaa  catggcccc  tttccccag  acaaaggga  1320
cagttggtg  ctgggaagg  attgaacgc  cctcaccct  tgcccgaag  gacccggaa  1380
caagaccat  gcagggcct  cgtggaagc  ggtccaggc  tttctagaa  cctagggtg  1440
accatcact  tcttttcag  gcaggctgt  acagcccac  caggagaca  tgagagtga  1500
aaggtatta  ggaaaaagc  cccagcggc  ctatggggg  tccctggtg  atgcctgct  1560
ctgtccctg  attaccaca  gtgccctcc  tgccaccct  cgtctagag  aagcggatg  1620
cccccagcc  gcagcagaa  cctccacag  gagaactgg  cccaaaggt  gtgggggcc  1680
gtgtggggc  gagtcctga  gagccacct  taggaggca  cccctagga  cacgcacgt  1740
ctgtcagta  taccccacc  gtcctatca  gtgggccac  ccctgcttg  ccacaccag  1800
gtctgtcct  gtcctcaag  cacgcaccc  ctatgcctg  actgcagcc  agccccgga  1860
agctccagg  tccgtgcag  ggctgcgcc  ccaggcccc  acaatgggg  ccctggggt  1920
gctcctggc  aagtgttct  tgttttcct  gcacctcct  acactgtgt  acctgcagg  1980
catgaggta  tgatgtgtt  gggtttcct  tcccaagcc  gcagatgca  gtgttccaa  2040
gtgtgttgc  ctgtgggat  tgtggacac  taagaaacg  actgagtgg  aaccctgca  2100
ccaggggat  gggagcctc  gctcccccc  tgctcccac  ctggctgag  gccagcctc  2160
tctgcagag  cctggagga  gcccaccta  ggacacagc  cgagagatg  gcgcaaggg  2220
tgctggggg  ggcctgcta  cctgcctct  ggccacttg  ggggcctca  gaagtgtgt  2280
cttgtggct  catctgccc  tctccctgg  ccaccatgt  gctgcaggc  aagctcttc  2340
ttgctgacc  tgaagagac  tagttacct  ccaagggat  ccccttccc  cctcctcag  2400
gtggggtga  caaggctcc  atcccaccc  accccaaaa  gagaaaaat  aaaaactca  2460
agtttggag  caggaggca  ggtgtccta  agggctgca  agccctgag  ggtcagtgc  2520
gggatctgg  tggttggtt  gtctttttg  ctttttttt  ttttttttt  ttttacaca  2580
tcattaatg  gatttgtct  cagccacca  tgttggcct  gaagcagag  gcacagccc  2640
tggtgtttg  aaaataagt  tgaatacac  gtgtggcag  gttgtggtt  ttgttgttg  2700
ttttcctct  cttttgaga  ttttctttt  taaaagaaa  atatttttt  aaccgaaat  2760
tgtggatga  atagaagct  gagccctcc  cttggaata  tcagcctaa  aacctcata  2820
gactatgaa  tcacccgaa  ttctcattt  ccatcaggc  gagctttta  agaaaaatt  2880
ttctctaac  aggattgta  caaaagtgt  aatactgtt  cagagttga  agttggtgg  2940
gcaaatatg  atataatga  ctgtatttt  acaatgatc  ccgcatgac  atttcacac  3000
ctttttata  tccatatct  tcttccaga  acgtcacct  cctttctcc  gtggtctct  3060
aatccagta  ttgtattac  gccattaaa  gatgcagtt  ttttaaaaa  aaaaaaaaa  3120
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaa  3174



<210> 6157
<211> 484
<212> DNA
<213> Rattus norvegicus
<308> AA893980
<400> 6157

aaaataact  catccttta  tggcagtaa  acaattact  gattaagag  ccacatgag  60
aggcaggtg  ggtttctgg  agacagata  tgagtacaa  aggggcggg  gagccatgc  120
acgatcatt  taaaaatac  gtacgttat  tacatattt  caccatcga  tttcaactc  180
gaaatacta  ttacacgtt  gttacaatc  tggttagag  acaatcttt  tttacgagt  240
tggcctgac  gcaagtggg  attcaagcg  atgtccttg  tccatgagg  ccttcagtt  300
actgttccg  aggaaggct  cagactcca  ctcacccac  gatttcagc  ttaaaaatt  360
atttaattt  ttctttagc  aaaggacag  ttttttcta  tatagacca  gctggcttt  420
aacctgtga  cctcctgcc  ctcctcctg  gtgccggga  gacaggcgc  ctaccaagc  480
tggc  484



<210> 6158
<211> 3174
<212> DNA
<213> Homo sapiens
<308> AL050155
<400> 6158

aggacgcag  gccccccgt  cccgcggcc  tgcaatcca  gcccaccct  gacccccgg  60
tgcaccgcg  tgccacggc  gggcccccc  acgcccggc  gcgcccggg  gcctccacg  120
attccagca  acagggcgc  aacctcccc  actttgaac  tctgtctcg  atcctcaag  180
cagtcaatg  caccggctc  tcggccgcc  ccggttcca  cgacaaacc  agtgacccc  240
gggtgcgga  ggcccccac  gaccctcgg  tgcagaaac  cacagactc  acggcctcc  300
cccgggctg  caagcccgg  cctgctgag  cgccctctc  caccgccag  ccgagtggg  360
atgcctccc  accagccac  gctccctac  acccccgcg  gctggcggc  ggtggactg  420
gccagggcg  agggggcgg  cagagcagt  tgctgagcg  tatcagcct  tacgacccg  480
ggactccca  cgcgggggg  aaagccaca  agccggctg  tgacacggg  gcccagccc  540
agggtgctg  gggcaatgg  aagagctcg  cctccaagg  taaggagcc  ccgttcgtc  600
gcaagtctg  cctggaaca  ccagagaca  ggaaggccg  tgctgatgg  ggcaccccc  660
cggacagat  caacagcta  aaccggccc  ggcccaagg  tgctgcagc  cccgctgcc  720
ccaccgcca  cccaccccc  gagggtgcc  caccccagc  cggggtgca  aacctgccc  780
tgcccaccc  cttcgggac  gtgaagcag  cacccaaga  gggctcagg  agcccattt  840
ctgggaaca  tccggcccg  gagggtgag  aggatgcgg  atccctgaa  gatgttttt  900
aaggcttcg  ccccacggc  tcccccttt  gccagtagt  tccagccag  gctgcggct  960
cagccaccc  tcctagggt  gcattcagg  cagcaccca  ggtagggaa  ttgggggca  1020
ggggaggca  gctgggtgt  ccttttttc  tttcttttt  ttttgcttt  cgtctcttt  1080
atttttttt  aaagtagta  tttctttga  atttgtaaa  tgtatataa  catcttaag  1140
tctggtcag  gtggcgggc  caggggctc  tgctgagca  accgactca  gcccgcaaa  1200
ctgtgaact  tcgccagtg  ctggcctca  actctgtgg  ctctgcgtg  ccgggcctt  1260
ctggaggcc  agtgggttt  ctgggcaaa  catggcccc  tttccccag  acaaaggga  1320
cagttggtg  ctgggaagg  attgaacgc  cctcaccct  tgcccgaag  gacccggaa  1380
caagaccat  gcagggcct  cgtggaagc  ggtccaggc  tttctagaa  cctagggtg  1440
accatcact  tcttttcag  gcaggctgt  acagcccac  caggagaca  tgagagtga  1500
aaggtatta  ggaaaaagc  cccagcggc  ctatggggg  tccctggtg  atgcctgct  1560
ctgtccctg  attaccaca  gtgccctcc  tgccaccct  cgtctagag  aagcggatg  1620
cccccagcc  gcagcagaa  cctccacag  gagaactgg  cccaaaggt  gtgggggcc  1680
gtgtggggc  gagtcctga  gagccacct  taggaggca  cccctagga  cacgcacgt  1740
ctgtcagta  taccccacc  gtcctatca  gtgggccac  ccctgcttg  ccacaccag  1800
gtctgtcct  gtcctcaag  cacgcaccc  ctatgcctg  actgcagcc  agccccgga  1860
agctccagg  tccgtgcag  ggctgcgcc  ccaggcccc  acaatgggg  ccctggggt  1920
gctcctggc  aagtgttct  tgttttcct  gcacctcct  acactgtgt  acctgcagg  1980
catgaggta  tgatgtgtt  gggtttcct  tcccaagcc  gcagatgca  gtgttccaa  2040
gtgtgttgc  ctgtgggat  tgtggacac  taagaaacg  actgagtgg  aaccctgca  2100
ccaggggat  gggagcctc  gctcccccc  tgctcccac  ctggctgag  gccagcctc  2160
tctgcagag  cctggagga  gcccaccta  ggacacagc  cgagagatg  gcgcaaggg  2220
tgctggggg  ggcctgcta  cctgcctct  ggccacttg  ggggcctca  gaagtgtgt  2280
cttgtggct  catctgccc  tctccctgg  ccaccatgt  gctgcaggc  aagctcttc  2340
ttgctgacc  tgaagagac  tagttacct  ccaagggat  ccccttccc  cctcctcag  2400
gtggggtga  caaggctcc  atcccaccc  accccaaaa  gagaaaaat  aaaaactca  2460
agtttggag  caggaggca  ggtgtccta  agggctgca  agccctgag  ggtcagtgc  2520
gggatctgg  tggttggtt  gtctttttg  ctttttttt  ttttttttt  ttttacaca  2580
tcattaatg  gatttgtct  cagccacca  tgttggcct  gaagcagag  gcacagccc  2640
tggtgtttg  aaaataagt  tgaatacac  gtgtggcag  gttgtggtt  ttgttgttg  2700
ttttcctct  cttttgaga  ttttctttt  taaaagaaa  atatttttt  aaccgaaat  2760
tgtggatga  atagaagct  gagccctcc  cttggaata  tcagcctaa  aacctcata  2820
gactatgaa  tcacccgaa  ttctcattt  ccatcaggc  gagctttta  agaaaaatt  2880
ttctctaac  aggattgta  caaaagtgt  aatactgtt  cagagttga  agttggtgg  2940
gcaaatatg  atataatga  ctgtatttt  acaatgatc  ccgcatgac  atttcacac  3000
ctttttata  tccatatct  tcttccaga  acgtcacct  cctttctcc  gtggtctct  3060
aatccagta  ttgtattac  gccattaaa  gatgcagtt  ttttaaaaa  aaaaaaaaa  3120
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaa  3174



<210> 6159
<211> 443
<212> DNA
<213> Rattus norvegicus
<308> AA893984
<400> 6159

gactggttt  gaagcagtt  taatggaga  gaaaatgtt  tatcaactc  acacaggta  60
ccccaaaat  caaatcaaa  tatcatctt  agctgcata  caaatatga  ttaagaatt  120
aacatcatt  ttcgatcac  agcgtaaat  taagttcac  ataaataat  taaattcat  180
gtacaaaaa  tccccaaca  ctcttaata  aaatatggt  cacatttga  agtctctga  240
acagaattc  ttttaaaac  ttttaaaat  taagctttt  tcttgattt  taaatacat  300
aaaaaaaat  aaagagggg  gtggggtgg  aaacaagga  cactagaga  gaaagagca  360
taaagttgt  cagtgtctg  agacaagtg  tgcagaaat  gaatctctg  cctcaaagt  420
aggaccttg  tttattggg  tca  443



<210> 6160
<211> 1634
<212> DNA
<213> Homo sapiens
<308> NM_030778
<400> 6160

acgatgaag  cagtgagga  gaggaatag  aattgtcaa  gagctttta  taccaagat  60
caccccctg  ccccaaaga  gagtcctct  ttagggaat  agaaccttc  ttgtcctag  120
agctgaaag  ttcttggaa  attttagct  ttactctca  cttgctgtt  tctttacat  180
ccttaagtt  gactttcgg  tgtggcttc  ctctcaggg  taacattta  ttccatttt  240
tagaccgaa  caaaagtct  ctgcagaat  tcccaccga  tgtggtaag  aggaaggac  300
aaaggcttt  ggatataaa  ttcatgtta  agagcatgt  attgtcaaa  gaaatctgt  360
gccctgaga  tttaagaac  taaaatgtg  catttgata  ttctccagc  cagggaagt  420
agatggtta  caatggttg  cttaatcaa  tggtcccat  tttaacccc  aaggaagtg  480
ccacagcaa  aggtttgtg  gatgcactt  tgtcctccg  tgaggaaag  gggccacat  540
tgaaaggcc  cttaggtca  atcctgaga  tagcacatt  gagtgcaga  tcctgggcc  600
cacctcaaa  ctactaatt  tgaatctct  ggaataggg  caggaaatc  gccctttct  660
caaactacc  aagttgttc  gttgcacat  aatgtttgg  aaccactgc  gtaagggaa  720
cattctggt  accttgagc  ttgagctac  actaagcca  gaaagaaaa  acatcatac  780
gggaagaga  aagggagga  gttccaagt  gtaactggc  gatcctcct  tctggaggt  840
ccaccttct  ttctggttt  tgacttttc  ttcttgatg  ccatagatg  gttccagag  900
caaaagaga  acattatcc  agatggcag  acatgcttt  aaaacatat  aaatgtcaa  960
gttccagat  cttctacat  tttagtcct  tctgaggat  gtagctggc  ctctgtagc  1020
gatagatgg  tagagttcc  tccaaatcc  tgaccacga  ttcatggag  tttgaataa  1080
ctatttgat  agatttcta  ttcaataac  cacctctct  accccacat  catatccct  1140
aatttgacc  tctgggccg  gtcacatta  cttcaggag  cttgatccc  gtagactga  1200
gtcttccct  tcagcagaa  gatttcatt  ccctggctt  ccagtggca  tgatttccg  1260
acacccaat  agtttaata  tctttcctc  ttggcatta  tgccccagc  gcttttttt  1320
tttttttgt  tgtgtctaa  aaccaggaa  aaaataaag  ttaggtttt  aaaagtttt  1380
aaaataatc  gtttcagaa  ctgtcaaat  taccatatt  gtattaaga  ttgttggga  1440
tttttgtac  atgaattta  atttattta  ggtgacata  ttacgcttg  gatcaaata  1500
tgatgttaa  ttcttaaat  atatttgct  tgcagctga  gatgatatt  tgatttgta  1560
tttgggggt  cctgtgttg  gttgataaa  atttccatc  tcattaaaa  tgcttccaa  1620
ctaaaaaaa  aaaa  1634



<210> 6161
<211> 64
<212> PRT
<213> Homo sapiens
<308> XP_029757
<400> 6161

Met Val Ser Asn Gly Cys Leu Asn Gln Met Val Pro Phe Leu Thr Pro 
  1               5                  10                  15
Lys Glu Val Pro Thr Ala Arg Gly Leu Cys Asp Ala Leu Met Ser Ser 
             20                  25                  30
Gly Glu Glu Arg Gly Pro His Met Lys Gly Pro Leu Gly Gln Ile Leu 
         35                  40                  45
Arg Val Ala His Leu Ser Ala Asp Ser Trp Ala Pro Pro Gln Thr Tyr 
     50                  55                  60



<210> 6162
<211> 498
<212> DNA
<213> Rattus norvegicus
<308> AA894029
<400> 6162

cagcatcaa  gcaagcttt  atagttatt  ctaaaaatt  tctccagat  atcttctac  60
ccagactat  catatacaa  ggctgcaag  attcaaatt  cataaacat  atactgcaa  120
agcggaaaa  cccaggaaa  tcgtttcta  acttatatt  tcattttat  tttgttact  180
aagacagat  tcagtatct  ttactaaat  ctaagaact  actgtggag  gagttgtgc  240
ggcagctgg  ggctgggag  caggaactt  ggaggaaaa  gaaggaagt  ctcaaacaa  300
aagcacatg  gcactgcac  cattttcca  ctcataacc  gaataactc  gtgtagatc  360
ctattttgg  aactatgtt  atatcaact  ttgcctgct  atgggatcc  tttcctcct  420
ctgggttgc  tcatccaga  ttgataaga  ggtttgtgc  tgttcttat  gcatcttgt  480
atgctgtgt  cagctgat  498



<210> 6163
<211> 621
<212> DNA
<213> Rattus norvegicus
<308> AA894084
<400> 6163

ggcaagaga  ctgaattta  ttacagcta  gcatctatg  cttagacat  cgtttaaaa  60
caacaaaaa  aaaaagaag  ggcaatacc  agtcgataa  gaaaaaatg  tataatcta  120
agcttaaca  agtatgtat  tgctggaaa  gactgtttc  atattcagc  gataccggc  180
atacagtat  aaaagaaac  ctttttttt  cctttcctt  agcagtacc  catgtagct  240
aggctaact  aatctgcta  gtcaccaac  ctggtcctg  tccaccagc  tgcctccca  300
gggctagga  tccaggcat  agccaccag  cagggctaa  caataattc  tgatttaga  360
atctaaagt  tctagtgga  gtttgacac  tccagaatc  cgtaggtct  cgggcgggg  420
agtggtgtg  ttggtggta  ttgcctagc  cacgtacaa  gttctgggt  gctcctgag  480
tactgggaa  ggtagtgca  acccgtcac  aggaatcag  aagacgaac  ggttcaatg  540
caccttcag  ctggcccac  gggtaaagg  gcttgatga  gacatacat  gacaanaga  600
cataacatg  accccccat  c  621



<210> 6164
<211> 647
<212> DNA
<213> Rattus norvegicus
<308> AA894088
<400> 6164

aactcaaaa  aaaagcttt  tattctgat  tgtacaaca  aaaaattta  tatataatg  60
cagattatt  gaaagaaga  ataaaatgg  aagagtaga  ttctgttta  aaaaatact  120
tcaggcatc  gctaaacac  tgtaattcc  cacagacaa  agcttacaa  gcttagacc  180
ctttgcttt  aaaaatgtt  tgaattaat  gattcacat  taccaaaca  cttgggcat  240
gcgagaaac  tcacttcct  tcttggtag  aaaaacagc  ttgtttaac  cggaatacc  300
agcgacagt  tagccgaga  caagtcttg  aggaactga  tagcagttt  ttttggttc  360
gtaatatct  tcttagtaa  acccattcc  gatcgctgc  gcagcacag  aacaaaaca  420
ctgctctta  cgatttgga  gccatggat  tgggtgtct  gattctcac  gagacccac  480
gagggagca  cttgctctc  ttgtgtgga  gacgctcag  acataactg  gaaacagac  540
caggccgag  gaatgatcc  tagccagag  agcttctgc  tggtaaaca  ttccccgaa  600
gaaaagaaa  tatctgact  gattcattc  ggacaaagg  caatgca  647



<210> 6165
<211> 580
<212> DNA
<213> Rattus norvegicus
<308> AA894099
<400> 6165

caagaaggg  aagggttta  tagacatct  caggacagg  ccagcagag  ctgggctca  60
ttctcagtt  tcagtgaag  cagcgataa  gacctgcct  tctgccgtc  ctcctgata  120
aaacggcat  gtgctcaca  aagccatca  ctcctgcaa  gaggacctg  agctccaga  180
gcaagctta  gagggtggg  tggcttttc  tactttacc  cagtcagct  acaagtagc  240
aaagttaag  ggaaaggag  gagagcagg  gcctggtgg  tcccactcc  taacacttt  300
cagatgatt  tcctcttta  ttataaaca  gacagaaat  aaagcagca  taatttagg  360
gaacaaaag  tagacaaaa  cagatcagg  cagagtgtg  gcatccagt  gtgaagtgt  420
cagagccag  gtcacgtgt  ctacatggt  aagcatctc  gcagctgcc  aggcccctc  480
ttcatccta  taggtcggc  gccaggcag  agagggaat  ctattgact  cacgacttc  540
ggccctgcc  ggccactgg  gtgggaagt  ccatgaattt  580



<210> 6166
<211> 112
<212> PRT
<213> Rattus norvegicus
<308> BAB31873
<400> 6166

Thr Glu Gly Tyr Ser Gly Ala Asp Ile Ser Ile Ile Val Arg Asp Ser 
  1               5                  10                  15
Leu Met Gln Pro Val Arg Lys Val Gln Ser Ala Thr His Phe Lys Lys 
             20                  25                  30
Val Cys Gly Pro Ser Arg Thr Asn Pro Ser Val Met Ile Asp Asp Leu 
         35                  40                  45
Leu Thr Pro Cys Ser Pro Gly Asp Pro Gly Ala Ile Glu Met Thr Trp 
     50                  55                  60
Met Asp Val Pro Gly Asp Lys Leu Leu Glu Pro Val Val Cys Met Ser 
 65                  70                  75                  80
Asp Met Leu Arg Ser Leu Ala Thr Thr Arg Pro Thr Val Asn Ala Asp 
                 85                  90                  95
Asp Leu Leu Lys Val Lys Lys Phe Ser Glu Asp Phe Gly Gln Glu Ser 
             100                105                110



<210> 6167
<211> 1981
<212> DNA
<213> Homo sapiens
<308> NM_005606
<400> 6167

ggcacgagg  aggctgcga  ccgccgcga  ttctcacgg  cccgccggc  ccaccaccg  60
ggtcactca  cgccgccgc  gccaccact  ccaccacgg  cgcctgcca  aggtgtctg  120
aattgaact  caaggtgca  aatggtttg  aaagtagct  tattcctca  tgtggccct  180
ggcattggt  ccattccta  agatgatcc  gaagatgga  gcaagcact  ggtggtgat  240
gtggcaggt  caaatggct  gtataatta  aggcaccag  cagacgcgt  ccatgccta  300
cagatcatt  accgcaatg  gattcctga  gaacagatc  ttgtgatga  gtacgatga  360
attgcttac  ctgaagaca  tcccactcc  ggaattgtg  tcaacaggc  caatggcac  420
gatgtctat  agggagtcc  gaaggacta  actggagag  atgttaccc  acaaaattt  480
cttgctgtg  tgagaggcg  tgcagaagc  gtgaagggc  taggatccg  caaagtcct  540
aagagtggc  cccaggatc  cgtgttcat  tacttcact  accatggat  tactggaat  600
ctggttttt  ccaatgaag  tcttcatgt  aaggacctg  atgagacca  ccattacat  660
tacaaacac  aaatgtacc  aaagatggt  ttctacatt  aagcctgtg  gtctgggtc  720
atgatgaac  acctgccgg  taacatcaa  gtttatgca  ctactgctg  caaccccag  780
gagtcgtcc  acgcctgtt  ctatgatga  aagaggtcc  cgtacctgg  ggactggta  840
agcgtcaac  ggatggaag  ctcggacgt  gaagatctg  ctaaagaga  cctgcacaa  900
cagtaccac  tggtaaaat  gcacaccaa  accagccac  tcatgcagt  tggaaacaa  960
acaatctcc  ccatgaaag  gatgcagtt  cagggtatg  aacgcaaag  cagttctcc  1020
gtcccccta  ctccagtca  acaccttga  ctcaccccc  gccctgatg  gcctctcac  1080
atcatgaaa  ggaaactga  gaacaccaa  gatctggag  agtccaggc  gctcacgga  1140
gagatccag  ggcatctgg  tgccaggca  ctcattgag  agtcagtgc  taagatcgt  1200
tccttgctg  cagcgtccg  ggctgaggt  gagcagctc  tgtccgaga  agccccgct  1260
acggggcac  gctgctacc  agaggccct  ctgcacttc  ggacccact  cttcaactg  1320
cactccccc  cgtacgagt  tgcgttgag  catttgtac  tgctggtca  cctttgtga  1380
aagccgtat  cacttcaca  gataaaatt  tccatggac  acgtgtgcc  tggtcacta  1440
tgaagagct  cctcctgga  gcttttcca  gtgtgagcg  cccaccgac  gtgtgctga  1500
cagagactg  agaggtgga  tgagaagtc  ccgctgctc  ggccctcct  gggagcccc  1560
gctccaggg  tcgctccag  accttcttc  caagatgac  tgctcgctg  tacctgctt  1620
cccagtctt  tctgaaaaa  tacaaatta  ggtgggaaa  gctctgtat  gagaagggt  1680
atatttgct  tctaggagg  ttgttgttt  gcctgttag  tttgaggag  aggaagctc  1740
tgggggctt  tgtagcccc  ctcaaaagg  gtctttatt  tgagaattt  aagctgaaa  1800
ctctttaaa  cttcagaat  attttattg  agagggccg  aagccccaa  tggaaaact  1860
tttttagaa  atatgatga  ttttgattg  ttttgtatt  aattctgca  gtgttcaag  1920
cttaaaaaa  aaagattta  aacagaacc  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1980
a  1981



<210> 6168
<211> 433
<212> PRT
<213> Homo sapiens
<308> Q99538
<400> 6168

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
  1               5                  10                  15
Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
             20                  25                  30
Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
         35                  40                  45
Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
     50                  55                  60
Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn 
 65                  70                  75                  80
Pro Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr 
                 85                  90                  95
Gln Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln Asn 
             100                105                110
Phe Leu Ala Val Leu Arg Gly Asp Ala Glu Ala Val Lys Gly Ile Gly 
         115                120                125
Ser Gly Lys Val Leu Lys Ser Gly Pro Gln Asp His Val Phe Ile Tyr 
     130                135                140
Phe Thr Asp His Gly Ser Thr Gly Ile Leu Val Phe Pro Asn Glu Asp 
 145                150                155                160
Leu His Val Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His 
                 165                170                175
Lys Met Tyr Arg Lys Met Val Phe Tyr Ile Glu Ala Cys Glu Ser Gly 
             180                185                190
Ser Met Met Asn His Leu Pro Asp Asn Ile Asn Val Tyr Ala Thr Thr 
         195                200                205
Ala Ala Asn Pro Arg Glu Ser Ser Tyr Ala Cys Tyr Tyr Asp Glu Lys 
     210                215                220
Arg Ser Thr Tyr Leu Gly Asp Trp Tyr Ser Val Asn Trp Met Glu Asp 
 225                230                235                240
Ser Asp Val Glu Asp Leu Thr Lys Glu Thr Leu His Lys Gln Tyr His 
                 245                250                255
Leu Val Lys Ser His Thr Asn Thr Ser His Val Met Gln Tyr Gly Asn 
             260                265                270
Lys Thr Ile Ser Thr Met Lys Val Met Gln Phe Gln Gly Met Lys Arg 
         275                280                285
Lys Ala Ser Ser Pro Val Pro Leu Pro Pro Val Thr His Leu Asp Leu 
     290                295                300
Thr Pro Ser Pro Asp Val Pro Leu Thr Ile Met Lys Arg Lys Leu Met 
 305                310                315                320
Asn Thr Asn Asp Leu Glu Glu Ser Arg Gln Leu Thr Glu Glu Ile Gln 
                 325                330                335
Arg His Leu Asp Ala Arg His Leu Ile Glu Lys Ser Val Arg Lys Ile 
             340                345                350
Val Ser Leu Leu Ala Ala Ser Glu Ala Glu Val Glu Gln Leu Leu Ser 
         355                360                365
Glu Arg Ala Pro Leu Thr Gly His Ser Cys Tyr Pro Glu Ala Leu Leu 
     370                375                380
His Phe Arg Thr His Cys Phe Asn Trp His Ser Pro Thr Tyr Glu Tyr 
 385                390                395                400
Ala Leu Arg His Leu Tyr Val Leu Val Asn Leu Cys Glu Lys Pro Tyr 
                 405                410                415
Pro Leu His Arg Ile Lys Leu Ser Met Asp His Val Cys Leu Gly His 
             420                425                430
Tyr 
         435



<210> 6169
<211> 350
<212> DNA
<213> Rattus norvegicus
<308> AA894104
<400> 6169

aaagtcaga  ctggctgag  ttcaggggt  cagcaacag  tcaaggaag  gtgaagctg  60
ctgttggtc  ccaccaccg  gagttgggg  gggggtttc  tgccaacag  tgaggctcc  120
cgcagctcc  gggcgatgc  caagcaggg  gagggtggt  acggggaga  ggaagctcc  180
gacgctccg  cactgctgg  ttcttctcc  cactcctgt  ccttttcag  acagcctgg  240
tacccagct  gcctggggc  gagcaaagg  ccacgacca  tggagggac  tggatgggg  300
cagagcacc  agggaaggg  ccctcggcc  aagggagga  ggaaatggcc  350



<210> 6170
<211> 382
<212> PRT
<213> Rattus norvegicus
<308> BAB62016
<400> 6170

Met Leu Arg Trp Thr Val His Leu Glu Gly Gly Pro Arg Arg Val Asn 
  1               5                  10                  15
His Ala Thr Val Ala Val Gly His Arg Val Tyr Ser Phe Gly Gly Tyr 
             20                  25                  30
Cys Ser Gly Glu Asp Tyr Glu Thr Leu Arg Gln Ile Asp Val His Ile 
         35                  40                  45
Phe Asn Ala Val Ser Leu Arg Trp Thr Lys Leu Pro Pro Val Arg Pro 
     50                  55                  60
Ala Val Arg Gly Gln Ala Pro Val Val Pro Tyr Met Arg Tyr Gly His 
 65                  70                  75                  80
Ser Thr Val Leu Ile Asp Asp Thr Val Phe Leu Trp Gly Gly Arg Asn 
                 85                  90                  95
Asp Thr Glu Gly Ala Cys Asn Val Leu Tyr Ala Phe Asp Val Asn Thr 
             100                105                110
His Lys Trp Ser Thr Pro Arg Val Ser Gly Ala Val Pro Gly Ala Arg 
         115                120                125
Asp Gly His Ser Ala Cys Val Leu Gly Lys Ile Met Tyr Ile Phe Gly 
     130                135                140
Gly Tyr Glu Gln Leu Ala Asp Cys Phe Ser Asn Asp Ile His Lys Leu 
 145                150                155                160
Asp Thr Ser Thr Met Thr Trp Thr Leu Val Cys Thr Lys Gly Asn Pro 
                 165                170                175
Ala Arg Trp Arg Asp Phe His Ser Ala Thr Met Leu Gly Asn His Met 
             180                185                190
Tyr Val Phe Gly Gly Arg Ala Asp Arg Phe Gly Pro Phe His Ser Asn 
         195                200                205
Asn Glu Ile Tyr Cys Asn Arg Ile Arg Val Phe Asp Thr Arg Thr Glu 
     210                215                220
Ala Trp Leu Asp Cys Pro His Thr Pro Val Leu Pro Glu Gly Arg Arg 
 225                230                235                240
Ser His Ser Ala Phe Gly Tyr Asn Gly Glu Leu Tyr Ile Phe Gly Gly 
                 245                250                255
Tyr Asn Ala Arg Leu Asn Arg His Phe His Asp Leu Trp Lys Phe Asn 
             260                265                270
Pro Gly Ser Phe Thr Trp Lys Lys Ile Glu Pro Lys Gly Lys Gly Pro 
         275                280                285
Cys Pro Arg Arg Arg Gln Cys Cys Cys Ile Val Gly Asp Lys Ile Val 
     290                295                300
Leu Phe Gly Gly Thr Ser Pro Ser Pro Glu Glu Gly Leu Gly Asp Glu 
 305                310                315                320
Phe Asp Leu Ile Asp His Ser Asp Leu His Ile Leu Asp Phe Ser Pro 
                 325                330                335
Ser Leu Lys Thr Leu Cys Lys Leu Ala Val Ile Gln Tyr Ser Leu Asp 
             340                345                350
Gln Ser Cys Leu Pro His Asp Ile Arg Trp Glu Leu Asn Ala Met Thr 
         355                360                365
Thr Asn Ser Asn Ile Ser Arg Pro Ile Val Ser Ser His Gly 
     370                375                380



<210> 6171
<211> 362
<212> DNA
<213> Rattus norvegicus
<308> AA894119
<400> 6171

caacgtttg  agctgtgtg  ctttgcagc  cagcaattc  taaaccaca  tgtacagaa  60
caccagcaa  actggaatg  tgttataca  ggcaccatc  tgcttatta  attaccaga  120
aacaaaata  aggaaagac  gtttctact  tacacagtt  aaagaaagg  aaggggagg  180
gtgtgttga  cagccattg  tcacagggt  ggcttcata  taagcgctg  tagcattct  240
ttgcacagg  tccggagat  gctgcctgt  ttcttgttc  tcctccact  catcttctg  300
ctcttcatc  agttctggt  cggaatctc  aaatacttc  tcctcataa  gaaacatat  360
at  362



<210> 6172
<211> 1501
<212> DNA
<213> Homo sapiens
<308> AF070615
<400> 6172

aagatgaag  gtttggtga  tctgagcct  aacttgatg  agaatcaga  gatgaagta  60
aagaggaac  agaagaaag  caaccatct  ctgaacctg  gcaagaaaa  gctaacagt  120
gttactatg  agctcaccc  gtgactaat  gcatagagg  gcctttgga  gaatcctct  180
atgaacctg  acctgagcc  gaatctgaa  caaagactg  agagctgaa  ccacaagtg  240
aggagaaga  cttagaaga  ctagaggag  aatctacta  tcctcctcc  gcagaacct  300
tttctctgc  acaagaacc  ccaaaggct  tctcctggg  ttcagtgac  agtaaaaac  360
tgcctccta  tggtactgt  tcttcctct  gaattccac  ccatgttaa  gcaccagtc  420
cacagccaa  agtcgaagc  aaaccagaa  ttcaatctc  gccacctcg  gtgcgtgaa  480
aacgaccta  agaacgacc  ggttttcct  ctagaggac  aagaccagg  agaggagat  540
tggaacaga  tgactctga  aaccgtaga  taattcgct  tccagatag  catcaactt  600
ttgttggta  cttgccaca  gatattgat  aaaatgagc  aaaggaatt  ttcatgagt  660
ttggaaacg  tgtggaact  cgcatcaat  ccaagggtg  tgggggaaa  cttccaaat  720
ttggttttg  ggtttttga  gactctgaa  cagttcaga  aatcttaat  gcaaaaccg  780
ttatgtttc  aggggaagt  cgtttaaat  tggaagaga  aaaaacaag  gctgcaaga  840
agcgagaaa  cagaggtgg  ggtgatgat  gcagggata  taggcgcaa  gatcgaggt  900
ccggtggtc  acgtggaat  gtgggtggt  gaatgatgc  tgatcgtga  ggaagagga  960
ctcctccaa  gggtggcat  gcacagaaa  ttggctctg  aagaggaac  gggcaaatg  1020
agggccgct  cacaggaca  cgtcgctga  gctccactg  tggcaaagt  ttggcagtg  1080
tacattatt  atcgtgttt  cattcttgt  aattttttt  ttggctttg  aatgtgaca  1140
agccttttt  atcatttct  tgatgtgaa  agcatcttt  gttatcagt  aaattgagg  1200
ggacattat  tccccaatt  cacaacagg  ttcacattg  taatttata  atctagact  1260
ggagaatta  ggactgaga  atgaccata  cttaaacta  ctacgacaa  gtgaactta  1320
aaggacatg  ccactgaat  caggtcctt  gagtaaaaa  aaaatcttc  gctgcacat  1380
ttgtttaag  gttactgtt  ctgcctgtt  atgctggga  cacaaatag  gcaatttgt  1440
caattggag  atcttgcct  ttttcttgg  tccccccaa  aaaaaaaaa  aaaaaaaaa  1500
a  1501



<210> 6173
<211> 482
<212> PRT
<213> Homo sapiens
<308> Q9UN86
<400> 6173

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
  1               5                  10                  15
Arg Gln Tyr Tyr Thr Leu Leu Asn Lys Ala Pro Glu Tyr Leu His Arg 
             20                  25                  30
Phe Tyr Gly Arg Asn Ser Ser Tyr Val His Gly Gly Val Asp Ala Ser 
         35                  40                  45
Gly Lys Pro Gln Glu Ala Val Tyr Gly Gln Asn Asp Ile His His Lys 
     50                  55                  60
Val Leu Ser Leu Asn Phe Ser Glu Cys His Thr Lys Ile Arg His Val 
 65                  70                  75                  80
Asp Ala His Ala Thr Leu Ser Asp Gly Val Val Val Gln Val Met Gly 
                 85                  90                  95
Leu Leu Ser Asn Ser Gly Gln Pro Glu Arg Lys Phe Met Gln Thr Phe 
             100                105                110
Val Leu Ala Pro Glu Gly Ser Val Pro Asn Lys Phe Tyr Val His Asn 
         115                120                125
Asp Met Phe Arg Tyr Glu Asp Glu Val Phe Gly Asp Ser Glu Pro Glu 
     130                135                140
Leu Asp Glu Glu Ser Glu Asp Glu Val Glu Glu Glu Gln Glu Glu Arg 
 145                150                155                160
Gln Pro Ser Pro Glu Pro Val Gln Glu Asn Ala Asn Ser Gly Tyr Tyr 
                 165                170                175
Glu Ala His Pro Val Thr Asn Gly Ile Glu Glu Pro Leu Glu Glu Ser 
             180                185                190
Ser His Glu Pro Glu Pro Glu Pro Glu Ser Glu Thr Lys Thr Glu Glu 
         195                200                205
Leu Lys Pro Gln Val Glu Glu Lys Asn Leu Glu Glu Leu Glu Glu Lys 
     210                215                220
Ser Thr Thr Pro Pro Pro Ala Glu Pro Val Ser Leu Pro Gln Glu Pro 
 225                230                235                240
Pro Lys Ala Phe Ser Trp Ala Ser Val Thr Ser Lys Asn Leu Pro Pro 
                 245                250                255
Ser Gly Thr Val Ser Ser Ser Gly Ile Pro Ser His Val Lys Ala Pro 
             260                265                270
Val Ser Gln Pro Arg Val Glu Ala Lys Pro Glu Val Gln Ser Gln Pro 
         275                280                285
Pro Arg Val Arg Glu Gln Arg Pro Arg Glu Arg Pro Gly Phe Pro Pro 
     290                295                300
Arg Gly Pro Arg Pro Gly Arg Gly Asp Met Glu Gln Asn Asp Ser Asp 
 305                310                315                320
Asn Arg Arg Ile Ile Arg Tyr Pro Asp Ser His Gln Leu Phe Val Gly 
                 325                330                335
Asn Leu Pro His Asp Ile Asp Glu Asn Glu Leu Lys Glu Phe Phe Met 
             340                345                350
Ser Phe Gly Asn Val Val Glu Leu Arg Ile Asn Thr Lys Gly Val Gly 
         355                360                365
Gly Lys Leu Pro Asn Phe Gly Phe Val Val Phe Asp Asp Ser Glu Pro 
     370                375                380
Val Gln Arg Ile Leu Ile Ala Lys Pro Ile Met Phe Arg Gly Glu Val 
 385                390                395                400
Arg Leu Asn Val Glu Glu Lys Lys Thr Arg Ala Ala Arg Glu Arg Glu 
                 405                410                415
Thr Arg Gly Gly Gly Asp Asp Arg Arg Asp Ile Arg Arg Asn Asp Arg 
             420                425                430
Gly Pro Gly Gly Pro Arg Gly Ile Val Gly Gly Gly Met Met Arg Asp 
         435                440                445
Arg Asp Gly Arg Gly Pro Pro Pro Arg Gly Gly Met Ala Gln Lys Leu 
     450                455                460
Gly Ser Gly Arg Gly Thr Gly Gln Met Glu Gly Arg Phe Thr Gly Gln 
 465                470                475                480
Arg Arg 
                 485



<210> 6174
<211> 494
<212> DNA
<213> Rattus norvegicus
<308> AA894130
<400> 6174

aaaaggccc  ctttattaa  cacattctt  ctttcagaa  cctgatttt  aaaaaacct  60
tatctacta  aaaacagac  tataaatca  gcaaacagt  aagactaca  gaatggggc  120
cctagtgac  ctgaaggag  cgataggtg  ggaagggca  agggctgtg  ggagggagg  180
caggaagag  ctctacgca  cccacaggc  gggaaacaa  gaccaaact  cctaatgat  240
tcaggcaca  gcgttgctc  gtcatggtg  cccccaggc  ctctgagaa  tggggcctc  300
acaagacac  ggtattctt  accagctgc  ccttgtcat  cgcagtgct  caaacagtg  360
ggagagcac  ctcctgctt  ctgcgaacc  ttcggatca  gaacaccat  gaggatccc  420
ggaggagga  caggaccat  atgaacagc  ccaccagga  caccgcttt  gtgcccgga  480
tcaggaaag  atac  494



<210> 6175
<211> 252
<212> PRT
<213> Rattus norvegicus
<308> AAD22174
<400> 6175

Met Ala Gln Leu Cys Glu Leu Arg Arg Gly Arg Ala Leu Leu Ala Leu 
  1               5                  10                  15
Val Ala Ser Leu Leu Leu Ser Gly Ala Gln Val Ala Ser Arg Glu Leu 
             20                  25                  30
Asp Val His Glu Ser Cys Gly Val Ser Lys Val Val Gly Lys Cys Arg 
         35                  40                  45
Ala Ser Ile Pro Arg Trp Trp Tyr Asn Ile Thr Asp Gly Ser Cys Gln 
     50                  55                  60
Pro Phe Val Tyr Gly Gly Cys Glu Gly Asn Gly Asn Asn Tyr Gln Ser 
 65                  70                  75                  80
Lys Glu Glu Cys Leu Asp Lys Cys Ala Gly Val Thr Glu Asn Thr Thr 
                 85                  90                  95
Asp Asp Met Ala Arg Asn Arg Asn Gly Ala Asp Ser Ser Val Leu Ser 
             100                105                110
Val Pro Arg Lys Gln Ser Ala Glu Asp Leu Ser Ala Glu Ile Phe Asn 
         115                120                125
Tyr Glu Glu Tyr Cys Val Pro Lys Ala Val Thr Gly Pro Cys Arg Ala 
     130                135                140
Ala Phe Pro Arg Trp Tyr Tyr Asp Thr Glu Lys Asn Ser Cys Ile Ser 
 145                150                155                160
Phe Ile Tyr Gly Gly Cys Arg Gly Asn Lys Asn Ser Tyr Leu Ser Gln 
                 165                170                175
Glu Ala Cys Met Gln His Cys Ser Gly Lys Gln Met His Pro Phe Leu 
             180                185                190
Thr Pro Gly Leu Lys Ala Val Ile Leu Val Gly Leu Phe Leu Met Val 
         195                200                205
Leu Ile Leu Leu Leu Gly Thr Ser Met Val Cys Leu Ile Arg Val Val 
     210                215                220
Arg Arg Lys Gln Glu Arg Ala Leu Arg Thr Val Trp Ser Thr Ala Asp 
 225                230                235                240
Asp Lys Glu Gln Leu Val Lys Asn Thr Cys Val Leu 
                 245                250



<210> 6176
<211> 1544
<212> DNA
<213> Homo sapiens
<308> U78095
<400> 6176

gcacgagtt  ggaggtgta  cgcggctct  aacgcgctg  gggccgttg  gtgtcgcag  60
cggcgaggg  gcgagtgag  agcagaccc  ggcatcgcg  gccgagaag  ccgggcgtc  120
ccacactga  ggtccggaa  ggcgacttc  gggggcttt  gcacctggc  gaccctccc  180
gagcgtcgg  acctgaacg  gaggcgctc  attgcgcgt  cgcgttgag  ggcttcccg  240
acctgatcg  gagacccca  cggctggtg  cgtcgcctg  gcgtctcgg  tgagctggc  300
atggcgcag  tgtgcgggc  gaggcggag  cgggcgttt  tcgccctgc  gggatcgct  360
ctcctctct  gggtcctgg  ggccgaccg  gaacgcagc  tccacgact  ctgcctggt  420
tcgaaggtg  tgggcagat  ccgggcctc  atgcctagg  ggtggtaca  tgtcactga  480
ggatcctgc  agctgtttg  gtatggggg  tgtgacgga  acagcaata  ttacctgac  540
aaggaggag  gcctcaaga  atgtgccac  gtcacagag  atgccacgg  tgacctggc  600
accagcagg  atgcagcgg  ttcctctgt  ccaagtgct  ccagaaggc  ggattctga  660
gaccactcc  gcgatatgt  caactatga  gaatactgc  ccgccaacg  agtcactgg  720
ccttgccgt  catccttcc  acgctggta  tttgacgtg  agaggaact  ctgcaataa  780
ttcatctat  gaggctgcc  gggcaataa  aacagctac  gctctgagg  ggcctgcat  840
ctccgctgc  tccgccagc  ggagaatcc  cccctgccc  ttggctcaa  ggtggtggt  900
ctggcgggg  tgttcgtga  ggtgttgat  ctcttcctg  gagcctcca  ggtctacct  960
atccgggtg  cacggagga  ccaggagcg  gccctgcgc  ccgtctgga  ctccggaga  1020
gacaaggag  agctggtga  gaacacata  gtcctgtga  cgccctgtc  ccaagagga  1080
tggggaagg  aggggagac  atgtgtgag  tttttttaa  tagagggat  gactcggat  1140
tgagtgatc  ttagggctg  ggtctgttt  tctgggagg  aggacggct  cttcctggt  1200
tggcaggga  gggtttgct  tggaaatcc  ctaggaggc  cctcctcgc  tggcctgca  1260
tctggcagc  gccccgagt  gtttcctcg  tgatcgatt  ctttcctcc  ggtagagtt  1320
tctttgctt  tgttgaatt  cattgcctc  ttttctcna  cacagaagt  atgttggaa  1380
cgtttcttt  gtttgtctg  tttatggtt  ttttaagta  aaacaaaag  tttttatta  1440
cattctgaa  gaaggaaag  aaaatgtac  agtttaata  aaaggggcc  tccccttta  1500
aataaattt  cagcatgtt  ctttcaaaa  aaaaaaaaa  aaaa  1544



<210> 6177
<211> 252
<212> PRT
<213> Homo sapiens
<308> O43291
<400> 6177

Met Ala Gln Leu Cys Gly Leu Arg Arg Ser Arg Ala Phe Leu Ala Leu 
  1               5                  10                  15
Leu Gly Ser Leu Leu Leu Ser Gly Val Leu Ala Ala Asp Arg Glu Arg 
             20                  25                  30
Ser Ile His Asp Phe Cys Leu Val Ser Lys Val Val Gly Arg Cys Arg 
         35                  40                  45
Ala Ser Met Pro Arg Trp Trp Tyr Asn Val Thr Asp Gly Ser Cys Gln 
     50                  55                  60
Leu Phe Val Tyr Gly Gly Cys Asp Gly Asn Ser Asn Asn Tyr Leu Thr 
 65                  70                  75                  80
Lys Glu Glu Cys Leu Lys Lys Cys Ala Thr Val Thr Glu Asn Ala Thr 
                 85                  90                  95
Gly Asp Leu Ala Thr Ser Arg Asn Ala Ala Asp Ser Ser Val Pro Ser 
             100                105                110
Ala Pro Arg Arg Gln Asp Ser Glu Asp His Ser Ser Asp Met Phe Asn 
         115                120                125
Tyr Glu Glu Tyr Cys Thr Ala Asn Ala Val Thr Gly Pro Cys Arg Ala 
     130                135                140
Ser Phe Pro Arg Trp Tyr Phe Asp Val Glu Arg Asn Ser Cys Asn Asn 
 145                150                155                160
Phe Ile Tyr Gly Gly Cys Arg Gly Asn Lys Asn Ser Tyr Arg Ser Glu 
                 165                170                175
Glu Ala Cys Met Leu Arg Cys Phe Arg Gln Gln Glu Asn Pro Pro Leu 
             180                185                190
Pro Leu Gly Ser Lys Val Val Val Leu Ala Gly Leu Phe Val Met Val 
         195                200                205
Leu Ile Leu Phe Leu Gly Ala Ser Met Val Tyr Leu Ile Arg Val Ala 
     210                215                220
Arg Arg Asn Gln Glu Arg Ala Leu Arg Thr Val Trp Ser Ser Gly Asp 
 225                230                235                240
Asp Lys Glu Gln Leu Val Lys Asn Thr Tyr Val Leu 
                 245                250



<210> 6178
<211> 455
<212> DNA
<213> Rattus norvegicus
<308> AA894131
<400> 6178

aaagatata  actggcata  ctgtgagtt  ggtgcactg  ccaagtcca  cagtggaaa  60
attacaaaa  atacttaag  aatattcac  tagaaagca  ggtaggaga  tgtcctttg  120
aaagaacaa  tgcattccg  acaaatgag  gggctgtga  agtgtttcc  ggctctaga  180
cctcccacg  ggctgaggt  tactgactg  caaggggct  gccggcttc  ttcttgtcc  240
acactcact  aagtctcat  cgcttctca  ggggacctt  agtgcttac  gtctgctga  300
cgctctttg  gctctcctt  tcctcggac  ttacagttt  tggcagggg  tctgcctct  360
tctttgcct  gtccactgg  acaggcttc  ctccagact  ttgctgaac  aatctgggt  420
gaagtttct  tctgaggtc  atgagtaaa  catcc  455



<210> 6179
<211> 885
<212> DNA
<213> Homo sapiens
<308> U78082
<400> 6179

ctcgaggcc  agaattcgg  acgagggaa  ctgtaaacg  tctcggaat  atggcggcg  60
tggatatcc  agacaatct  ctgggaatt  cttgggttg  cagctcttg  atccctatt  120
tgaacagtg  tagtgtcct  gattacttt  cagaaagaa  taatccttt  tatgacaga  180
catgtaata  tgaagtggt  aaaatgcag  ggctaacat  agaacactt  aatcagatg  240
ttggaatcg  gtacatcct  ttgcatgct  aagagccca  tcttttcat  attcggaag  300
aacagcggc  gtcccctgc  caagttatc  cactagctg  ttactatat  attgctgga  360
tgatctatc  ggcaccaga  ttgggatca  ttataaact  tagagtgct  actgcagtg  420
atggtattc  gtcagcttt  gatgaagct  tgtcatact  tcgatatca  ccttccaaa  480
ggtattggt  gcacttcaa  gatcatgaa  agcaaggta  gtagaacat  cataccctc  540
taaaacact  tttgatcct  tgagaatga  gctgttttc  ttaggaaaa  ggctgttga  600
cttttctaa  tgtgtttca  tttttcatg  gatgatggc  ttgttgcag  tgagattca  660
gtaactaga  tggtaataa  agtttcaca  aggaacaga  gcaagttca  tctgttagt  720
aactggtag  ctttgttaa  gtgattcaa  gttttaaaa  atttggggc  aggtgtggt  780
gctcactcc  gtaatcccg  cactttgga  tgccaaggc  ggtggatca  ctgagccta  840
gagttcaag  tcagcctgg  caacatagt  aaacctggt  tctgc  885



<210> 6180
<211> 158
<212> PRT
<213> Homo sapiens
<308> U78082
<400> 6180

Met Ala Ala Val Asp Ile Arg Asp Asn Leu Leu Gly Ile Ser Trp Val 
  1               5                  10                  15
Asp Ser Ser Trp Ile Pro Ile Leu Asn Ser Gly Ser Val Leu Asp Tyr 
             20                  25                  30
Phe Ser Glu Arg Ser Asn Pro Phe Tyr Asp Arg Thr Cys Asn Asn Glu 
         35                  40                  45
Val Val Lys Met Gln Arg Leu Thr Leu Glu His Leu Asn Gln Met Val 
     50                  55                  60
Gly Ile Glu Tyr Ile Leu Leu His Ala Gln Glu Pro Ile Leu Phe Ile 
 65                  70                  75                  80
Ile Arg Lys Gln Gln Arg Gln Ser Pro Ala Gln Val Ile Pro Leu Ala 
                 85                  90                  95
Asp Tyr Tyr Ile Ile Ala Gly Val Ile Tyr Gln Ala Pro Asp Leu Gly 
             100                105                110
Ser Val Ile Asn Ser Arg Val Leu Thr Ala Val His Gly Ile Gln Ser 
         115                120                125
Ala Phe Asp Glu Ala Met Ser Tyr Cys Arg Tyr His Pro Ser Lys Gly 
     130                135                140
Tyr Trp Trp His Phe Lys Asp His Glu Glu Gln Gly Lys Ter 
 145                150                155



<210> 6181
<211> 447
<212> DNA
<213> Rattus norvegicus
<308> AA894148
<400> 6181

ctcagatgc  ttattgagt  acgagagga  gtatcgtca  ccacaggac  tgtgtcctc  60
agctggtac  agaagtgct  gggaacaga  tgacagaca  gtggtgggg  agggcaggt  120
tctgctgct  tgatgggcc  aggacacca  ggacagctc  gctctccag  ggtttgggc  180
gcacctgct  ctggacctg  tcctgaacc  gctccggga  ggggagggc  aggggctgg  240
ctgggctcc  ctttttttg  agggtcttc  ttccccgct  attccgcca  gcccgttcc  300
ttggctgtg  tttcgctgg  tagtaggta  ggacagtgg  aatctcgtt  atccattca  360
gcgcgtcac  aattagatg  cgaggcatt  ggctacctt  agagagtca  agttactct  420
gccgtttac  cgcgcttca  tgaattt  447



<210> 6182
<211> 391
<212> PRT
<213> Rattus norvegicus
<308> AAA40748
<400> 6182

Met Phe Leu Lys Ala Val Val Leu Thr Val Ala Leu Val Ala Ile Thr 
  1               5                  10                  15
Gly Thr Gln Ala Glu Val Thr Ser Asp Gln Val Ala Asn Val Met Trp 
             20                  25                  30
Asp Tyr Phe Thr Gln Leu Ser Asn Asn Ala Lys Glu Ala Val Glu Gln 
         35                  40                  45
Leu Gln Lys Thr Asp Val Thr Gln Gln Leu Asn Thr Leu Phe Gln Asp 
     50                  55                  60
Lys Leu Gly Asn Ile Asn Thr Tyr Ala Asp Asp Leu Gln Asn Lys Leu 
 65                  70                  75                  80
Val Pro Phe Ala Val Gln Leu Ser Gly His Leu Thr Lys Glu Thr Glu 
                 85                  90                  95
Arg Val Arg Glu Glu Ile Gln Lys Glu Leu Glu Asp Leu Arg Ala Asn 
             100                105                110
Met Met Pro His Ala Asn Lys Val Ser Gln Met Phe Gly Asp Asn Val 
         115                120                125
Gln Lys Leu Gln Glu His Leu Arg Pro Tyr Ala Thr Asp Leu Gln Ala 
     130                135                140
Gln Ile Asn Ala Gln Thr Gln Asp Met Lys Arg Gln Leu Thr Pro Tyr 
 145                150                155                160
Ile Gln Arg Met Gln Thr Thr Ile Gln Asp Asn Val Glu Asn Leu Gln 
                 165                170                175
Ser Ser Met Val Pro Phe Ala Asn Glu Leu Lys Glu Lys Phe Asn Gln 
             180                185                190
Asn Met Glu Gly Leu Lys Gly Gln Leu Thr Pro Arg Ala Asn Glu Leu 
         195                200                205
Lys Ala Thr Ile Asp Gln Asn Leu Glu Asp Leu Arg Ser Arg Leu Ala 
     210                215                220
Pro Leu Ala Glu Gly Val Gln Glu Lys Leu Asn His Gln Met Glu Gly 
 225                230                235                240
Leu Ala Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Gln Thr Lys Val 
                 245                250                255
Ser Thr Asn Ile Asp Gln Leu Gln Lys Asn Leu Ala Pro Leu Val Glu 
             260                265                270
Asp Val Gln Ser Lys Leu Lys Gly Asn Thr Glu Gly Leu Gln Lys Ser 
         275                280                285
Leu Glu Asp Leu Asn Lys Gln Leu Asp Gln Gln Val Glu Val Phe Arg 
     290                295                300
Arg Ala Val Glu Pro Leu Gly Asp Lys Phe Asn Met Ala Leu Val Gln 
 305                310                315                320
Gln Met Glu Lys Phe Arg Gln Gln Leu Gly Ser Asp Ser Gly Asp Val 
                 325                330                335
Glu Ser His Leu Ser Phe Leu Glu Lys Asn Leu Arg Glu Lys Val Ser 
             340                345                350
Ser Phe Met Ser Thr Leu Gln Lys Lys Gly Ser Pro Asp Gln Pro Leu 
         355                360                365
Ala Leu Pro Leu Pro Glu Gln Val Gln Glu Gln Val Gln Glu Gln Val 
     370                375                380
Gln Pro Lys Pro Leu Glu Ser 
 385                390



<210> 6183
<211> 3604
<212> DNA
<213> Homo sapiens
<308> M14642
<400> 6183

gagatttaa  gtatgtggg  ggctgtgct  aggttatat  taaatacta  gccatttta  60
atcaaggac  tgaacatcc  tggattttg  tatctgcag  gggtcctgg  atcaatttc  120
catggagac  gagagatga  cgtactacc  acttcgcaa  caatgtctt  tttaatgta  180
tgaaccatc  cattgttca  aggagaaac  gaagctcag  gctttgaat  actagacca  240
ggaggcaca  catgggagt  ggacatgaa  cactctaca  ttaaccctt  caggacaag  300
ccctgtctc  cacacccat  tgcccaaag  ctctccagg  ccccctcct  ttgggtgta  360
cttgacaag  gacctagat  ttagctcac  atgctgtct  cagtcctgg  tggtcccac  420
ccagtgtct  gtgctctga  atggagtca  cattagtgg  ggatgtgga  actgggggg  480
cctgtcttc  ctggggtag  cagaggaga  gtggacttt  ccccccatg  gcccggcac  540
aacccagag  cgccagcag  gcctcgagg  atcagtccc  ggctctagg  ctccctgag  600
tgtttctcc  actgttttc  gttcccctc  tcccttcca  gctgaggtt  gtggggtgg  660
ggtgggggg  cccacgcac  gaacagcca  cacttctaa  tatcgcctg  gccctgatc  720
gctgtcagc  tccacgtag  ctcagggtc  caaaagtcc  agaggcctc  tgggaatgt  780
tcaccttcc  gcgtggagt  acactgagg  aggaggagg  gagggcagc  aggggggtg  840
cgataggga  agagtttaa  tgtctggct  gctctgagc  tcagtcagt  cccactgca  900
cgcaggtga  ctctcctga  gacctctct  tcagctccc  tgattgtag  gaggatcca  960
tgtggcaag  aactcctcc  gcccagcaa  cagctcagg  tgttcctga  ggccgtggt  1020
ctgaccctg  ccctggtgg  tgtcgccgg  gagtagaag  tgtctttgg  tggcactcc  1080
gggctgctg  tctgagtag  gcaggatgg  ggctgagcc  aagcaaaag  acacttctg  1140
gtgcccatc  gcccccagc  ggacatgag  tctgcctgg  tgccaagtg  ctcacagga  1200
agctggccc  gtcccagtg  tgggcccat  ggcattggt  ctataccag  ttcacatat  1260
cctgtggct  ccaaaaagc  taagctcag  cagggaaaa  ggcaggttg  ggcaccccc  1320
ccatcatcc  gtctgcagc  cagagctgg  gcagagggg  cacacagga  acggggcct  1380
atgaattgc  ctctgttac  acccaggag  cagggctga  gtcagtgct  accaggtgg  1440
cacagtgat  tgggactac  tcagccagc  gagcaacaa  gccaaggag  ccgtggaac  1500
tctccagaa  tctgaactc  cccagcaac  caagtaaga  ggactacag  gtgcggtgg  1560
gacggggaa  tcttaaagg  catgcaatg  actggcaag  gttgagctt  gagacagga  1620
ccctgagct  aggataccc  ctgccctgc  actaactgg  cgggcctct  aacctagga  1680
ccacatatg  aaaccggaa  tttggaccg  ataatccct  ccatgtcct  ttgctttga  1740
gttctagag  ttgacaaat  gccacatcc  atcattcag  ctcatggaa  agagggagg  1800
aggaaaatg  catgtgagc  gatttctaa  acgtttcag  aagacaggc  ccagtggaa  1860
caaggggag  gaggtggga  tatttggga  gcccctggg  acaggcaag  aaagcagca  1920
cttgtgcca  tggaagacc  cagcagagg  caagaagac  acattgtgt  acacaatgt  1980
atcctatgg  ccagaacac  cctctggga  ggacctcaa  gtcccaccc  ctgcagaca  2040
ggaggggaa  gcaaactgc  ggaggtgac  tggtgggta  attctgaga  aaactatgt  2100
ggagatcct  agatagaaa  tcagcatcg  aacttagtc  gtgacaccc  tcctctcca  2160
tctgcacca  catagggag  gtgaactcg  tacctctga  cactcacct  tcttagcac  2220
tgtgcataa  gcgagtggt  tacaagcag  caaagtctt  ccgtgtaaa  gccaaatgt  2280
acgtggcct  cttgtgccc  tccccacag  gccctcttc  aggacaaac  tggagaagt  2340
aacacttac  caggtgacc  gcagaagaa  ctggtgccc  ttgccaccg  gctgcatga  2400
cgcctggcc  aggactcgg  gaaactgaa  gaggagatt  ggaaggagc  ggaggagct  2460
agggcccgg  tgctgcccc  tgccaatga  gtgagccag  agatcgggg  caacctgcg  2520
gagcttcag  agcgcctgg  gccctacgc  gaccagctg  gcacccagg  caacacgca  2580
gccgagcag  tgcggcgcc  gctggaccc  ctagcacag  gcatggaga  agtgctgcg  2640
gagaacgcc  acagcctgc  ggcctcgct  aggccccac  ccgacgagc  caaggccaa  2700
atcgaccag  acgtggagg  gctcaaggg  cgccttacg  cctacgctg  cgaattcaa  2760
gtcaagatt  accagaccg  ggaggagct  cgccgcagc  tggctccct  tgctcagga  2820
acgcaggag  agctcaacc  ccagcttga  ggcctgacc  tccagatga  gaagaacgc  2880
gaggagctc  aggccagga  ctcggccag  gccgaggag  tgcggcaga  gctggcgcc  2940
ttggccgag  acgtgcgtg  caacctgaa  ggcaacacc  aggggctgc  gaagtcact  3000
gcagagctg  gtgggcacc  ggaccagca  gtggaggag  tccgacgcc  ggtggagcc  3060
tacggggaa  acttcaaca  agccctggt  cagcagatg  aacagctca  gcagaaact  3120
ggcccccat  cgggggacg  ggaaggcca  ttgagcttc  tggagaagg  cctgaggga  3180
aaggtcaac  ccttcttca  caccttcaa  gagaaagag  gccaggaca  gactctctc  3240
ctccctgag  tggagcaac  gcaggaaca  cagcaggag  agcagcagg  gcaggtgca  3300
atgctggcc  ctttggaga  ctgagctgc  cctggtgca  tggccccac  ctcgtggac  3360
cctgccctg  cctgccacc  gtctgtctg  cccaaagaa  ttctggtat  aacttgagg  3420
cacatgtcc  gtgggaggt  agaccacct  tcaatattc  ataaagctg  tgagaatct  3480
gcctcaact  gttgccgga  gaatcctcc  tgcagctgg  gaggtgggg  ggtaaccat  3540
actgggcag  gcttagcag  ggcctggca  gagaccacc  aggattggg  agatgagac  3600
gcag  3604



<210> 6184
<211> 396
<212> PRT
<213> Homo sapiens
<308> P06727
<400> 6184

Met Phe Leu Lys Ala Val Val Leu Thr Leu Ala Leu Val Ala Val Ala 
  1               5                  10                  15
Gly Ala Arg Ala Glu Val Ser Ala Asp Gln Val Ala Thr Val Met Trp 
             20                  25                  30
Asp Tyr Phe Ser Gln Leu Ser Asn Asn Ala Lys Glu Ala Val Glu His 
         35                  40                  45
Leu Gln Lys Ser Glu Leu Thr Gln Gln Leu Asn Ala Leu Phe Gln Asp 
     50                  55                  60
Lys Leu Gly Glu Val Asn Thr Tyr Ala Gly Asp Leu Gln Lys Lys Leu 
 65                  70                  75                  80
Val Pro Phe Ala Thr Glu Leu His Glu Arg Leu Ala Lys Asp Ser Glu 
                 85                  90                  95
Lys Leu Lys Glu Glu Ile Gly Lys Glu Leu Glu Glu Leu Arg Ala Arg 
             100                105                110
Leu Leu Pro His Ala Asn Glu Val Ser Gln Lys Ile Gly Asp Asn Leu 
         115                120                125
Arg Glu Leu Gln Gln Arg Leu Glu Pro Tyr Ala Asp Gln Leu Arg Thr 
     130                135                140
Gln Val Asn Thr Gln Ala Glu Gln Leu Arg Arg Gln Leu Thr Pro Tyr 
 145                150                155                160
Ala Gln Arg Met Glu Arg Val Leu Arg Glu Asn Ala Asp Ser Leu Gln 
                 165                170                175
Ala Ser Leu Arg Pro His Ala Asp Glu Leu Lys Ala Lys Ile Asp Gln 
             180                185                190
Asn Val Glu Glu Leu Lys Gly Arg Leu Thr Pro Tyr Ala Asp Glu Phe 
         195                200                205
Lys Val Lys Ile Asp Gln Thr Val Glu Glu Leu Arg Arg Ser Leu Ala 
     210                215                220
Pro Tyr Ala Gln Asp Thr Gln Glu Lys Leu Asn His Gln Leu Glu Gly 
 225                230                235                240
Leu Thr Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Lys Ala Arg Ile 
                 245                250                255
Ser Ala Ser Ala Glu Glu Leu Arg Gln Arg Leu Ala Pro Leu Ala Glu 
             260                265                270
Asp Val Arg Gly Asn Leu Lys Gly Asn Thr Glu Gly Leu Gln Lys Ser 
         275                280                285
Leu Ala Glu Leu Gly Gly His Leu Asp Gln Gln Val Glu Glu Phe Arg 
     290                295                300
Arg Arg Val Glu Pro Tyr Gly Glu Asn Phe Asn Lys Ala Leu Val Gln 
 305                310                315                320
Gln Met Glu Gln Leu Arg Gln Lys Leu Gly Pro His Ala Gly Asp Val 
                 325                330                335
Glu Gly His Leu Ser Phe Leu Glu Lys Asp Leu Arg Asp Lys Val Asn 
             340                345                350
Ser Phe Phe Ser Thr Phe Lys Glu Lys Glu Ser Gln Asp Lys Thr Leu 
         355                360                365
Ser Leu Pro Glu Leu Glu Gln Gln Gln Glu Gln Gln Gln Glu Gln Gln 
     370                375                380
Gln Glu Gln Val Gln Met Leu Ala Pro Leu Glu Ser 
 385                390                395



<210> 6185
<211> 441
<212> DNA
<213> Rattus norvegicus
<308> AA894160
<400> 6185

aaaaggtac  ctgtttata  ttaaacaac  aagaaaaaa  gcatctaca  acttaaaaa  60
ttaattcga  attcctaaa  ctattttaa  tcattttaa  atactacat  cagaagcca  120
aatgcagag  taagaatgg  ggaaggtgg  gaaaagaaa  ggaccacaa  gaaaaacac  180
tagacaatt  cttgtctgt  gtgggtaaa  caacaggaa  cctgggata  aagaaatca  240
taacaagtt  gctcataac  gatattttc  cctcctgtt  gtttttaat  acgtccata  300
gggtgctct  tgtatgctc  cttcactgg  ctagctgga  gagccttca  tgatggcct  360
gtcncattc  agtcatctt  tccataggc  tcataagaa  cttgaagct  cccatgtcc  420
tagtcataa  actctgact  c  441



<210> 6186
<211> 443
<212> PRT
<213> Rattus norvegicus
<308> AAK77001
<400> 6186

Met Gln Arg Arg Asp Asp Pro Ala Ala Arg Leu Thr Arg Ser Ser Gly 
  1               5                  10                  15
Arg Ser Cys Ser Lys Asp Pro Ser Gly Ala His Pro Ser Val Arg Leu 
             20                  25                  30
Thr Pro Ser Arg Pro Ser Pro Leu Pro His Arg Ser Arg Gly Gly Gly 
         35                  40                  45
Gly Gly Pro Arg Gly Gly Ala Arg Ala Ser Pro Ala Thr Gln Pro Pro 
     50                  55                  60
Pro Leu Leu Pro Pro Ser Asn Pro Gly Pro Asp Ala Thr Val Val Gly 
 65                  70                  75                  80
Ser Ala Pro Thr Pro Leu Leu Pro Pro Ser Ala Thr Ala Ala Ala Lys 
                 85                  90                  95
Met Glu Pro Glu Asn Lys Tyr Leu Pro Glu Leu Met Ala Glu Lys Asp 
             100                105                110
Ser Leu Asp Pro Ser Phe Thr His Ala Met Gln Leu Leu Ser Val Glu 
         115                120                125
Ile Glu Lys Ile Gln Lys Gly Glu Ser Lys Lys Asp Asp Glu Glu Asn 
     130                135                140
Tyr Leu Asp Leu Phe Ser His Lys Asn Met Lys Leu Lys Glu Arg Val 
 145                150                155                160
Leu Ile Pro Val Lys Gln Tyr Pro Lys Phe Asn Phe Val Gly Lys Ile 
                 165                170                175
Leu Gly Pro Gln Gly Asn Thr Ile Lys Arg Leu Gln Glu Glu Thr Gly 
             180                185                190
Ala Lys Ile Ser Val Leu Gly Lys Gly Ser Met Arg Asp Lys Ala Lys 
         195                200                205
Glu Glu Glu Leu Arg Lys Gly Gly Asp Pro Lys Tyr Ala His Leu Asn 
     210                215                220
Met Asp Leu His Val Phe Ile Glu Val Phe Gly Pro Pro Cys Glu Ala 
 225                230                235                240
Tyr Ala Leu Met Ala His Ala Met Glu Glu Val Lys Lys Phe Leu Val 
                 245                250                255
Pro Asp Met Met Asp Asp Ile Cys Gln Glu Gln Phe Leu Glu Leu Ser 
             260                265                270
Tyr Leu Asn Gly Val Pro Glu Pro Ser Arg Gly Arg Gly Val Ser Val 
         275                280                285
Arg Gly Arg Gly Ala Ala Pro Pro Pro Pro Pro Val Pro Arg Gly Arg 
     290                295                300
Gly Val Gly Pro Pro Arg Gly Ala Leu Val Arg Gly Thr Pro Val Arg 
 305                310                315                320
Gly Ser Ile Thr Arg Gly Ala Thr Val Thr Arg Gly Val Pro Pro Pro 
                 325                330                335
Pro Thr Val Arg Gly Ala Pro Thr Pro Arg Ala Arg Thr Ala Gly Ile 
             340                345                350
Gln Arg Ile Pro Leu Pro Pro Thr Pro Ala Pro Glu Thr Tyr Glu Asp 
         355                360                365
Tyr Gly Tyr Asp Asp Ser Tyr Ala Glu Gln Ser Tyr Glu Gly Tyr Glu 
     370                375                380
Gly Tyr Tyr Ser Gln Ser Gln Gly Glu Ser Glu Tyr Tyr Asp Tyr Gly 
 385                390                395                400
His Gly Glu Leu Gln Asp Ser Tyr Glu Ala Tyr Gly Gln Asp Asp Trp 
                 405                410                415
Asn Gly Thr Arg Pro Ser Leu Lys Ala Pro Pro Ala Arg Pro Val Lys 
             420                425                430
Gly Ala Tyr Arg Glu His Pro Tyr Gly Arg Tyr 
         435                440



<210> 6187
<211> 1215
<212> DNA
<213> Homo sapiens
<308> U78971
<400> 6187

atgcagcgc  gggacgacc  cgccgcgcg  atgagccgg  cttcgggcc  tagcggctc  60
atggacccc  ccggtgccc  cccctcggt  cgtcagacg  cgtctcggc  gccgccgct  120
cctcaccgg  cccggggag  cggaggggg  tcccgcggg  gcgcccggg  ctcgcccgc  180
acgcagccg  caccgctgc  gccgccctc  gccacgggt  ccgacgcga  agtgggcgg  240
ccagcgccg  ccccgctgc  gcccccctc  gccacagcc  cggtcaaga  ggagccaga  300
aacaagtac  tgcccgaac  catggccga  aaggactcg  tcgacccgt  cttcactca  360
gccatgcag  tgctgacgg  agaaattga  aagattcag  aaggagact  aaaaaagga  420
gatgaggag  attacttgg  tttattttc  cataagaac  tgaaactga  agagcgagt  480
ctgatacct  tcaagcagt  tcccaagga  gaagagctg  gcaaaggtg  agaccccaa  540
tatgcccac  tgaatatgg  tctgcatgt  ttcattgaa  tctttggac  cccatgtga  600
gcttatgct  ttatggccc  tgccatgga  gaagtcaag  aatttctag  accggatat  660
atggatgat  tctgtcagg  gcaatttct  gagctgtcc  acttgaatg  agtacctga  720
ccctctcgt  gacgtgggg  gccagtgag  ggccgggga  ctgcacctc  tccaccacc  780
gttcccagg  gccgtggtg  tggaccacc  cggggggct  tggtacgtg  tacaccagt  840
aggggagcc  tcaccagag  tgccactgt  actcgaggc  tgccacccc  acctactgt  900
aggggtgct  cagcaccaa  agcacggac  gcgggcatc  agaggatac  tttgcctcc  960
cctcctgca  cagaaacat  tgaagaata  ggatatgat  atacatacg  agaacaaag  1020
tacgaaggc  acgaaggct  ttacagcca  agtcaaggg  actcagaat  ttatgacta  1080
ggacatggg  aggttcaag  ttcttatga  gcttatggc  aggacgact  gaatgggac  1140
aggccgtcg  tgaaggccc  tcctgctag  ccagtgaag  gagcataca  agagcaccc  1200
tatggacgt  attaa  1215



<210> 6188
<211> 443
<212> PRT
<213> Homo sapiens
<308> NP_006550
<400> 6188

Met Gln Arg Arg Asp Asp Pro Ala Ala Arg Met Ser Arg Ser Ser Gly 
  1               5                  10                  15
Arg Ser Gly Ser Met Asp Pro Ser Gly Ala His Pro Ser Val Arg Gln 
             20                  25                  30
Thr Pro Ser Arg Gln Pro Pro Leu Pro His Arg Ser Arg Gly Gly Gly 
         35                  40                  45
Gly Gly Ser Arg Gly Gly Ala Arg Ala Ser Pro Ala Thr Gln Pro Pro 
     50                  55                  60
Pro Leu Leu Pro Pro Ser Ala Thr Gly Pro Asp Ala Thr Val Gly Gly 
 65                  70                  75                  80
Pro Ala Pro Thr Pro Leu Leu Pro Pro Ser Ala Thr Ala Ser Val Lys 
                 85                  90                  95
Met Glu Pro Glu Asn Lys Tyr Leu Pro Glu Leu Met Ala Glu Lys Asp 
             100                105                110
Ser Leu Asp Pro Ser Phe Thr His Ala Met Gln Leu Leu Thr Ala Glu 
         115                120                125
Ile Glu Lys Ile Gln Lys Gly Asp Ser Lys Lys Asp Asp Glu Glu Asn 
     130                135                140
Tyr Leu Asp Leu Phe Ser His Lys Asn Met Lys Leu Lys Glu Arg Val 
 145                150                155                160
Leu Ile Pro Val Lys Gln Tyr Pro Lys Phe Asn Phe Val Gly Lys Ile 
                 165                170                175
Leu Gly Pro Gln Gly Asn Thr Ile Lys Arg Leu Gln Glu Glu Thr Gly 
             180                185                190
Ala Lys Ile Ser Val Leu Gly Lys Gly Ser Met Arg Asp Lys Ala Lys 
         195                200                205
Glu Glu Glu Leu Arg Lys Gly Gly Asp Pro Lys Tyr Ala His Leu Asn 
     210                215                220
Met Asp Leu His Val Phe Ile Glu Val Phe Gly Pro Pro Cys Glu Ala 
 225                230                235                240
Tyr Ala Leu Met Ala His Ala Met Glu Glu Val Lys Lys Phe Leu Val 
                 245                250                255
Pro Asp Met Met Asp Asp Ile Cys Gln Glu Gln Phe Leu Glu Leu Ser 
             260                265                270
Tyr Leu Asn Gly Val Pro Glu Pro Ser Arg Gly Arg Gly Val Pro Val 
         275                280                285
Arg Gly Arg Gly Ala Ala Pro Pro Pro Pro Pro Val Pro Arg Gly Arg 
     290                295                300
Gly Val Gly Pro Pro Arg Gly Ala Leu Val Arg Gly Thr Pro Val Arg 
 305                310                315                320
Gly Ala Ile Thr Arg Gly Ala Thr Val Thr Arg Gly Val Pro Pro Pro 
                 325                330                335
Pro Thr Val Arg Gly Ala Pro Ala Pro Arg Ala Arg Thr Ala Gly Ile 
             340                345                350
Gln Arg Ile Pro Leu Pro Pro Pro Pro Ala Pro Glu Thr Tyr Glu Glu 
         355                360                365
Tyr Gly Tyr Asp Asp Thr Tyr Ala Glu Gln Ser Tyr Glu Gly Tyr Glu 
     370                375                380
Gly Tyr Tyr Ser Gln Ser Gln Gly Asp Ser Glu Tyr Tyr Asp Tyr Gly 
 385                390                395                400
His Gly Glu Val Gln Asp Ser Tyr Glu Ala Tyr Gly Gln Asp Asp Trp 
                 405                410                415
Asn Gly Thr Arg Pro Ser Leu Lys Ala Pro Pro Ala Arg Pro Val Lys 
             420                425                430
Gly Ala Tyr Arg Glu His Pro Tyr Gly Arg Tyr 
         435                440



<210> 6189
<211> 670
<212> DNA
<213> Rattus norvegicus
<308> AA894174
<400> 6189

ctgagaata  ttttaaagg  aggtgaaac  ttattatat  ttttattat  gaattagaa  60
atgtcaaaa  taattgttt  gaatcacaa  aaattaaaa  ggaatataa  aattgattc  120
tcaaaaggc  ttctagctg  tgttagcat  ttttctttc  ttggattat  aacttctat  180
atttcaact  aatactttt  acagtttcc  taagatatg  ttttgactt  ttttttctt  240
agtatttct  tcatttcag  aaccacctt  aataaatct  caactattc  ataatctgc  300
acttggaaa  ttggagctt  tgggtcttt  ttaatagcc  caattgtct  gctgtcctt  360
atcccagct  aatgctgga  ggctccaga  attccaaca  caatataaa  ttctggagc  420
actattttt  ctgtctgac  aacttgcat  tcattggga  caaagccag  atcaacagc  480
gcacgggaa  caccaactg  agcatgcag  tgatctgcc  agtcataca  cagtttaaa  540
ttctctcca  tcttcaagc  ccgaccacc  gataccacc  ctttggcac  agttagctc  600
ggtcggtca  tttttgtca  tttctggtc  agccactct  atattcctg  tgatgaaag  660
acttggtgcc  670



<210> 6190
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> AAA41130
<400> 6190

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
  1               5                  10                  15
Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
             20                  25                  30
Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Gly Arg Leu Gly 
         35                  40                  45
Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Val 
     50                  55                  60
Gln Asp Leu Cys Lys Val Ala Gly Val Ala Lys Val Leu Val Ala Gln 
 65                  70                  75                  80
His Asp Ala Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                 85                  90                  95
Leu Glu Thr Gln Lys Gln Phe Ser Tyr Thr His Ile Val Ala Gly Ala 
             100                105                110
Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Asn 
         115                120                125
Val Ala Pro Val Ser Asp Ile Ile Glu Ile Lys Ser Pro Asp Thr Phe 
     130                135                140
Val Arg Thr Ile Tyr Ala Ala Asn Ala Leu Cys Thr Val Lys Cys Asp 
 145                150                155                160
Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Glu Ala Ala 
                 165                170                175
Ala Ala Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Pro Ser Ser Ser 
             180                185                190
Ser Ala Gly Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
         195                200                205
Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
     210                215                220
Leu Lys Ser Gly Glu Asn Phe Lys Leu Gln Tyr Asp Leu Ala Asp Gln 
 225                230                235                240
Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                 245                250                255
Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
             260                265                270
Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
         275                280                285
Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
     290                295                300
Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
 305                310                315                320
Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                 325                330



<210> 6191
<211> 911
<212> DNA
<213> Homo sapiens
<308> BE535809
<400> 6191

tggtggctc  gcatgatgt  tacaaaggc  tacttccag  ggaactgac  ccattgatt  60
ggcaactca  aagcagttc  attacacac  catctgtgc  ggagcatct  ccttcggaa  120
gaacctttt  cccagagta  cagccaaac  tgaggttgc  ccgatttct  acatcattg  180
aatcaagtc  cctgacaca  ttgtgagaa  tatttatgc  ggaaatgct  tatgtacag  240
gaagtgtga  gagaaagtg  aagtgtttt  tgtccgtgg  acatccttt  atgctgcag  300
aacaagtgg  ggtagtgcc  gttcagaaa  ggcatcaag  acttcacca  tggaaatat  360
agagtggct  gaccagaaa  taacaaaaa  tgatcgacc  gagctaaca  gtgccaaag  420
ggtggtatc  ggtggtcga  gcttgaaga  tggagagaa  tttaagtgt  ttatatgac  480
tggcagatc  actacatgc  gcagtgggt  cttcccgtg  tgctgttga  gctggcttt  540
ttcccaatg  catgcaagt  ggcagacgg  aaaaatagt  gcaccagaa  tttatattg  600
tgttggata  ctgggagcc  tccaacatt  tagctggat  aacgacccg  cagaccatt  660
tggcaattg  ttaagaacc  agaagttcc  atttcccag  ggccgatat  ggtcgtgcg  720
ttatttagg  gtccggatg  ctggctttg  gagaactga  cggtctgct  gaaggaact  780
gtgggtccc  cgatcccat  gtggggttt  ccccttggg  cggggcgct  atgtgggcg  840
gtaccgccc  cgtggggcg  gcctccttg  ggccccttg  ccttcttcc  ctgcctaaa  900
ggcggctgc  g  911



<210> 6192
<211> 333
<212> PRT
<213> Homo sapiens
<308> P13804
<400> 6192

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
  1               5                  10                  15
Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
             20                  25                  30
Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Thr Arg Leu Gly 
         35                  40                  45
Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Ala 
     50                  55                  60
Gln Asp Leu Cys Lys Val Ala Gly Ile Ala Lys Val Leu Val Ala Gln 
 65                  70                  75                  80
His Asp Val Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                 85                  90                  95
Leu Ala Thr Gln Lys Gln Phe Asn Tyr Thr His Ile Cys Ala Gly Ala 
             100                105                110
Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Glu 
         115                120                125
Val Ala Pro Ile Ser Asp Ile Ile Ala Ile Lys Ser Pro Asp Thr Phe 
     130                135                140
Val Arg Thr Ile Tyr Ala Gly Asn Ala Leu Cys Thr Val Lys Cys Asp 
 145                150                155                160
Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Asp Ala Ala 
                 165                170                175
Ala Thr Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Ser Ser Thr Ser 
             180                185                190
Pro Val Glu Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
         195                200                205
Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
     210                215                220
Leu Lys Ser Gly Glu Asn Phe Lys Leu Leu Tyr Asp Leu Ala Asp Gln 
 225                230                235                240
Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                 245                250                255
Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
             260                265                270
Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
         275                280                285
Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
     290                295                300
Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
 305                310                315                320
Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                 325                330



<210> 6193
<211> 670
<212> DNA
<213> Rattus norvegicus
<308> AA894174
<400> 6193

ctgagaata  ttttaaagg  aggtgaaac  ttattatat  ttttattat  gaattagaa  60
atgtcaaaa  taattgttt  gaatcacaa  aaattaaaa  ggaatataa  aattgattc  120
tcaaaaggc  ttctagctg  tgttagcat  ttttctttc  ttggattat  aacttctat  180
atttcaact  aatactttt  acagtttcc  taagatatg  ttttgactt  ttttttctt  240
agtatttct  tcatttcag  aaccacctt  aataaatct  caactattc  ataatctgc  300
acttggaaa  ttggagctt  tgggtcttt  ttaatagcc  caattgtct  gctgtcctt  360
atcccagct  aatgctgga  ggctccaga  attccaaca  caatataaa  ttctggagc  420
actattttt  ctgtctgac  aacttgcat  tcattggga  caaagccag  atcaacagc  480
gcacgggaa  caccaactg  agcatgcag  tgatctgcc  agtcataca  cagtttaaa  540
ttctctcca  tcttcaagc  ccgaccacc  gataccacc  ctttggcac  agttagctc  600
ggtcggtca  tttttgtca  tttctggtc  agccactct  atattcctg  tgatgaaag  660
acttggtgcc  670



<210> 6194
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> AAA41130
<400> 6194

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
  1               5                  10                  15
Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
             20                  25                  30
Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Gly Arg Leu Gly 
         35                  40                  45
Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Val 
     50                  55                  60
Gln Asp Leu Cys Lys Val Ala Gly Val Ala Lys Val Leu Val Ala Gln 
 65                  70                  75                  80
His Asp Ala Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                 85                  90                  95
Leu Glu Thr Gln Lys Gln Phe Ser Tyr Thr His Ile Val Ala Gly Ala 
             100                105                110
Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Asn 
         115                120                125
Val Ala Pro Val Ser Asp Ile Ile Glu Ile Lys Ser Pro Asp Thr Phe 
     130                135                140
Val Arg Thr Ile Tyr Ala Ala Asn Ala Leu Cys Thr Val Lys Cys Asp 
 145                150                155                160
Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Glu Ala Ala 
                 165                170                175
Ala Ala Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Pro Ser Ser Ser 
             180                185                190
Ser Ala Gly Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
         195                200                205
Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
     210                215                220
Leu Lys Ser Gly Glu Asn Phe Lys Leu Gln Tyr Asp Leu Ala Asp Gln 
 225                230                235                240
Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                 245                250                255
Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
             260                265                270
Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
         275                280                285
Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
     290                295                300
Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
 305                310                315                320
Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                 325                330



<210> 6195
<211> 911
<212> DNA
<213> Homo sapiens
<308> BE535809
<400> 6195

tggtggctc  gcatgatgt  tacaaaggc  tacttccag  ggaactgac  ccattgatt  60
ggcaactca  aagcagttc  attacacac  catctgtgc  ggagcatct  ccttcggaa  120
gaacctttt  cccagagta  cagccaaac  tgaggttgc  ccgatttct  acatcattg  180
aatcaagtc  cctgacaca  ttgtgagaa  tatttatgc  ggaaatgct  tatgtacag  240
gaagtgtga  gagaaagtg  aagtgtttt  tgtccgtgg  acatccttt  atgctgcag  300
aacaagtgg  ggtagtgcc  gttcagaaa  ggcatcaag  acttcacca  tggaaatat  360
agagtggct  gaccagaaa  taacaaaaa  tgatcgacc  gagctaaca  gtgccaaag  420
ggtggtatc  ggtggtcga  gcttgaaga  tggagagaa  tttaagtgt  ttatatgac  480
tggcagatc  actacatgc  gcagtgggt  cttcccgtg  tgctgttga  gctggcttt  540
ttcccaatg  catgcaagt  ggcagacgg  aaaaatagt  gcaccagaa  tttatattg  600
tgttggata  ctgggagcc  tccaacatt  tagctggat  aacgacccg  cagaccatt  660
tggcaattg  ttaagaacc  agaagttcc  atttcccag  ggccgatat  ggtcgtgcg  720
ttatttagg  gtccggatg  ctggctttg  gagaactga  cggtctgct  gaaggaact  780
gtgggtccc  cgatcccat  gtggggttt  ccccttggg  cggggcgct  atgtgggcg  840
gtaccgccc  cgtggggcg  gcctccttg  ggccccttg  ccttcttcc  ctgcctaaa  900
ggcggctgc  g  911



<210> 6196
<211> 333
<212> PRT
<213> Homo sapiens
<308> P13804
<400> 6196

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
  1               5                  10                  15
Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
             20                  25                  30
Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Thr Arg Leu Gly 
         35                  40                  45
Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Ala 
     50                  55                  60
Gln Asp Leu Cys Lys Val Ala Gly Ile Ala Lys Val Leu Val Ala Gln 
 65                  70                  75                  80
His Asp Val Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                 85                  90                  95
Leu Ala Thr Gln Lys Gln Phe Asn Tyr Thr His Ile Cys Ala Gly Ala 
             100                105                110
Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Glu 
         115                120                125
Val Ala Pro Ile Ser Asp Ile Ile Ala Ile Lys Ser Pro Asp Thr Phe 
     130                135                140
Val Arg Thr Ile Tyr Ala Gly Asn Ala Leu Cys Thr Val Lys Cys Asp 
 145                150                155                160
Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Asp Ala Ala 
                 165                170                175
Ala Thr Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Ser Ser Thr Ser 
             180                185                190
Pro Val Glu Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
         195                200                205
Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
     210                215                220
Leu Lys Ser Gly Glu Asn Phe Lys Leu Leu Tyr Asp Leu Ala Asp Gln 
 225                230                235                240
Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                 245                250                255
Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
             260                265                270
Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
         275                280                285
Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
     290                295                300
Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
 305                310                315                320
Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                 325                330



<210> 6197
<211> 670
<212> DNA
<213> Rattus norvegicus
<308> AA894174
<400> 6197

ctgagaata  ttttaaagg  aggtgaaac  ttattatat  ttttattat  gaattagaa  60
atgtcaaaa  taattgttt  gaatcacaa  aaattaaaa  ggaatataa  aattgattc  120
tcaaaaggc  ttctagctg  tgttagcat  ttttctttc  ttggattat  aacttctat  180
atttcaact  aatactttt  acagtttcc  taagatatg  ttttgactt  ttttttctt  240
agtatttct  tcatttcag  aaccacctt  aataaatct  caactattc  ataatctgc  300
acttggaaa  ttggagctt  tgggtcttt  ttaatagcc  caattgtct  gctgtcctt  360
atcccagct  aatgctgga  ggctccaga  attccaaca  caatataaa  ttctggagc  420
actattttt  ctgtctgac  aacttgcat  tcattggga  caaagccag  atcaacagc  480
gcacgggaa  caccaactg  agcatgcag  tgatctgcc  agtcataca  cagtttaaa  540
ttctctcca  tcttcaagc  ccgaccacc  gataccacc  ctttggcac  agttagctc  600
ggtcggtca  tttttgtca  tttctggtc  agccactct  atattcctg  tgatgaaag  660
acttggtgcc  670



<210> 6198
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> AAA41130
<400> 6198

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
  1               5                  10                  15
Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
             20                  25                  30
Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Gly Arg Leu Gly 
         35                  40                  45
Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Val 
     50                  55                  60
Gln Asp Leu Cys Lys Val Ala Gly Val Ala Lys Val Leu Val Ala Gln 
 65                  70                  75                  80
His Asp Ala Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                 85                  90                  95
Leu Glu Thr Gln Lys Gln Phe Ser Tyr Thr His Ile Val Ala Gly Ala 
             100                105                110
Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Asn 
         115                120                125
Val Ala Pro Val Ser Asp Ile Ile Glu Ile Lys Ser Pro Asp Thr Phe 
     130                135                140
Val Arg Thr Ile Tyr Ala Ala Asn Ala Leu Cys Thr Val Lys Cys Asp 
 145                150                155                160
Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Glu Ala Ala 
                 165                170                175
Ala Ala Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Pro Ser Ser Ser 
             180                185                190
Ser Ala Gly Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
         195                200                205
Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
     210                215                220
Leu Lys Ser Gly Glu Asn Phe Lys Leu Gln Tyr Asp Leu Ala Asp Gln 
 225                230                235                240
Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                 245                250                255
Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
             260                265                270
Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
         275                280                285
Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
     290                295                300
Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
 305                310                315                320
Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                 325                330



<210> 6199
<211> 911
<212> DNA
<213> Homo sapiens
<308> BE535809
<400> 6199

tggtggctc  gcatgatgt  tacaaaggc  tacttccag  ggaactgac  ccattgatt  60
ggcaactca  aagcagttc  attacacac  catctgtgc  ggagcatct  ccttcggaa  120
gaacctttt  cccagagta  cagccaaac  tgaggttgc  ccgatttct  acatcattg  180
aatcaagtc  cctgacaca  ttgtgagaa  tatttatgc  ggaaatgct  tatgtacag  240
gaagtgtga  gagaaagtg  aagtgtttt  tgtccgtgg  acatccttt  atgctgcag  300
aacaagtgg  ggtagtgcc  gttcagaaa  ggcatcaag  acttcacca  tggaaatat  360
agagtggct  gaccagaaa  taacaaaaa  tgatcgacc  gagctaaca  gtgccaaag  420
ggtggtatc  ggtggtcga  gcttgaaga  tggagagaa  tttaagtgt  ttatatgac  480
tggcagatc  actacatgc  gcagtgggt  cttcccgtg  tgctgttga  gctggcttt  540
ttcccaatg  catgcaagt  ggcagacgg  aaaaatagt  gcaccagaa  tttatattg  600
tgttggata  ctgggagcc  tccaacatt  tagctggat  aacgacccg  cagaccatt  660
tggcaattg  ttaagaacc  agaagttcc  atttcccag  ggccgatat  ggtcgtgcg  720
ttatttagg  gtccggatg  ctggctttg  gagaactga  cggtctgct  gaaggaact  780
gtgggtccc  cgatcccat  gtggggttt  ccccttggg  cggggcgct  atgtgggcg  840
gtaccgccc  cgtggggcg  gcctccttg  ggccccttg  ccttcttcc  ctgcctaaa  900
ggcggctgc  g  911



<210> 6200
<211> 333
<212> PRT
<213> Homo sapiens
<308> P13804
<400> 6200

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
  1               5                  10                  15
Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
             20                  25                  30
Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Thr Arg Leu Gly 
         35                  40                  45
Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Ala 
     50                  55                  60
Gln Asp Leu Cys Lys Val Ala Gly Ile Ala Lys Val Leu Val Ala Gln 
 65                  70                  75                  80
His Asp Val Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                 85                  90                  95
Leu Ala Thr Gln Lys Gln Phe Asn Tyr Thr His Ile Cys Ala Gly Ala 
             100                105                110
Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Glu 
         115                120                125
Val Ala Pro Ile Ser Asp Ile Ile Ala Ile Lys Ser Pro Asp Thr Phe 
     130                135                140
Val Arg Thr Ile Tyr Ala Gly Asn Ala Leu Cys Thr Val Lys Cys Asp 
 145                150                155                160
Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Asp Ala Ala 
                 165                170                175
Ala Thr Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Ser Ser Thr Ser 
             180                185                190
Pro Val Glu Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
         195                200                205
Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
     210                215                220
Leu Lys Ser Gly Glu Asn Phe Lys Leu Leu Tyr Asp Leu Ala Asp Gln 
 225                230                235                240
Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                 245                250                255
Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
             260                265                270
Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
         275                280                285
Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
     290                295                300
Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
 305                310                315                320
Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                 325                330



<210> 6201
<211> 670
<212> DNA
<213> Rattus norvegicus
<308> AA894174
<400> 6201

ctgagaata  ttttaaagg  aggtgaaac  ttattatat  ttttattat  gaattagaa  60
atgtcaaaa  taattgttt  gaatcacaa  aaattaaaa  ggaatataa  aattgattc  120
tcaaaaggc  ttctagctg  tgttagcat  ttttctttc  ttggattat  aacttctat  180
atttcaact  aatactttt  acagtttcc  taagatatg  ttttgactt  ttttttctt  240
agtatttct  tcatttcag  aaccacctt  aataaatct  caactattc  ataatctgc  300
acttggaaa  ttggagctt  tgggtcttt  ttaatagcc  caattgtct  gctgtcctt  360
atcccagct  aatgctgga  ggctccaga  attccaaca  caatataaa  ttctggagc  420
actattttt  ctgtctgac  aacttgcat  tcattggga  caaagccag  atcaacagc  480
gcacgggaa  caccaactg  agcatgcag  tgatctgcc  agtcataca  cagtttaaa  540
ttctctcca  tcttcaagc  ccgaccacc  gataccacc  ctttggcac  agttagctc  600
ggtcggtca  tttttgtca  tttctggtc  agccactct  atattcctg  tgatgaaag  660
acttggtgcc  670



<210> 6202
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> AAA41130
<400> 6202

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
  1               5                  10                  15
Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
             20                  25                  30
Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Gly Arg Leu Gly 
         35                  40                  45
Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Val 
     50                  55                  60
Gln Asp Leu Cys Lys Val Ala Gly Val Ala Lys Val Leu Val Ala Gln 
 65                  70                  75                  80
His Asp Ala Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                 85                  90                  95
Leu Glu Thr Gln Lys Gln Phe Ser Tyr Thr His Ile Val Ala Gly Ala 
             100                105                110
Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Asn 
         115                120                125
Val Ala Pro Val Ser Asp Ile Ile Glu Ile Lys Ser Pro Asp Thr Phe 
     130                135                140
Val Arg Thr Ile Tyr Ala Ala Asn Ala Leu Cys Thr Val Lys Cys Asp 
 145                150                155                160
Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Glu Ala Ala 
                 165                170                175
Ala Ala Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Pro Ser Ser Ser 
             180                185                190
Ser Ala Gly Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
         195                200                205
Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
     210                215                220
Leu Lys Ser Gly Glu Asn Phe Lys Leu Gln Tyr Asp Leu Ala Asp Gln 
 225                230                235                240
Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                 245                250                255
Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
             260                265                270
Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
         275                280                285
Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
     290                295                300
Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
 305                310                315                320
Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                 325                330



<210> 6203
<211> 911
<212> DNA
<213> Homo sapiens
<308> BE535809
<400> 6203

tggtggctc  gcatgatgt  tacaaaggc  tacttccag  ggaactgac  ccattgatt  60
ggcaactca  aagcagttc  attacacac  catctgtgc  ggagcatct  ccttcggaa  120
gaacctttt  cccagagta  cagccaaac  tgaggttgc  ccgatttct  acatcattg  180
aatcaagtc  cctgacaca  ttgtgagaa  tatttatgc  ggaaatgct  tatgtacag  240
gaagtgtga  gagaaagtg  aagtgtttt  tgtccgtgg  acatccttt  atgctgcag  300
aacaagtgg  ggtagtgcc  gttcagaaa  ggcatcaag  acttcacca  tggaaatat  360
agagtggct  gaccagaaa  taacaaaaa  tgatcgacc  gagctaaca  gtgccaaag  420
ggtggtatc  ggtggtcga  gcttgaaga  tggagagaa  tttaagtgt  ttatatgac  480
tggcagatc  actacatgc  gcagtgggt  cttcccgtg  tgctgttga  gctggcttt  540
ttcccaatg  catgcaagt  ggcagacgg  aaaaatagt  gcaccagaa  tttatattg  600
tgttggata  ctgggagcc  tccaacatt  tagctggat  aacgacccg  cagaccatt  660
tggcaattg  ttaagaacc  agaagttcc  atttcccag  ggccgatat  ggtcgtgcg  720
ttatttagg  gtccggatg  ctggctttg  gagaactga  cggtctgct  gaaggaact  780
gtgggtccc  cgatcccat  gtggggttt  ccccttggg  cggggcgct  atgtgggcg  840
gtaccgccc  cgtggggcg  gcctccttg  ggccccttg  ccttcttcc  ctgcctaaa  900
ggcggctgc  g  911



<210> 6204
<211> 333
<212> PRT
<213> Homo sapiens
<308> P13804
<400> 6204

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
  1               5                  10                  15
Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
             20                  25                  30
Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Thr Arg Leu Gly 
         35                  40                  45
Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Ala 
     50                  55                  60
Gln Asp Leu Cys Lys Val Ala Gly Ile Ala Lys Val Leu Val Ala Gln 
 65                  70                  75                  80
His Asp Val Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                 85                  90                  95
Leu Ala Thr Gln Lys Gln Phe Asn Tyr Thr His Ile Cys Ala Gly Ala 
             100                105                110
Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Glu 
         115                120                125
Val Ala Pro Ile Ser Asp Ile Ile Ala Ile Lys Ser Pro Asp Thr Phe 
     130                135                140
Val Arg Thr Ile Tyr Ala Gly Asn Ala Leu Cys Thr Val Lys Cys Asp 
 145                150                155                160
Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Asp Ala Ala 
                 165                170                175
Ala Thr Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Ser Ser Thr Ser 
             180                185                190
Pro Val Glu Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
         195                200                205
Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
     210                215                220
Leu Lys Ser Gly Glu Asn Phe Lys Leu Leu Tyr Asp Leu Ala Asp Gln 
 225                230                235                240
Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                 245                250                255
Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
             260                265                270
Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
         275                280                285
Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
     290                295                300
Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
 305                310                315                320
Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                 325                330



<210> 6205
<211> 670
<212> DNA
<213> Rattus norvegicus
<308> AA894174
<400> 6205

ctgagaata  ttttaaagg  aggtgaaac  ttattatat  ttttattat  gaattagaa  60
atgtcaaaa  taattgttt  gaatcacaa  aaattaaaa  ggaatataa  aattgattc  120
tcaaaaggc  ttctagctg  tgttagcat  ttttctttc  ttggattat  aacttctat  180
atttcaact  aatactttt  acagtttcc  taagatatg  ttttgactt  ttttttctt  240
agtatttct  tcatttcag  aaccacctt  aataaatct  caactattc  ataatctgc  300
acttggaaa  ttggagctt  tgggtcttt  ttaatagcc  caattgtct  gctgtcctt  360
atcccagct  aatgctgga  ggctccaga  attccaaca  caatataaa  ttctggagc  420
actattttt  ctgtctgac  aacttgcat  tcattggga  caaagccag  atcaacagc  480
gcacgggaa  caccaactg  agcatgcag  tgatctgcc  agtcataca  cagtttaaa  540
ttctctcca  tcttcaagc  ccgaccacc  gataccacc  ctttggcac  agttagctc  600
ggtcggtca  tttttgtca  tttctggtc  agccactct  atattcctg  tgatgaaag  660
acttggtgcc  670



<210> 6206
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> AAA41130
<400> 6206

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
  1               5                  10                  15
Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
             20                  25                  30
Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Gly Arg Leu Gly 
         35                  40                  45
Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Val 
     50                  55                  60
Gln Asp Leu Cys Lys Val Ala Gly Val Ala Lys Val Leu Val Ala Gln 
 65                  70                  75                  80
His Asp Ala Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                 85                  90                  95
Leu Glu Thr Gln Lys Gln Phe Ser Tyr Thr His Ile Val Ala Gly Ala 
             100                105                110
Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Asn 
         115                120                125
Val Ala Pro Val Ser Asp Ile Ile Glu Ile Lys Ser Pro Asp Thr Phe 
     130                135                140
Val Arg Thr Ile Tyr Ala Ala Asn Ala Leu Cys Thr Val Lys Cys Asp 
 145                150                155                160
Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Glu Ala Ala 
                 165                170                175
Ala Ala Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Pro Ser Ser Ser 
             180                185                190
Ser Ala Gly Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
         195                200                205
Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
     210                215                220
Leu Lys Ser Gly Glu Asn Phe Lys Leu Gln Tyr Asp Leu Ala Asp Gln 
 225                230                235                240
Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                 245                250                255
Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
             260                265                270
Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
         275                280                285
Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
     290                295                300
Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
 305                310                315                320
Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                 325                330



<210> 6207
<211> 911
<212> DNA
<213> Homo sapiens
<308> BE535809
<400> 6207

tggtggctc  gcatgatgt  tacaaaggc  tacttccag  ggaactgac  ccattgatt  60
ggcaactca  aagcagttc  attacacac  catctgtgc  ggagcatct  ccttcggaa  120
gaacctttt  cccagagta  cagccaaac  tgaggttgc  ccgatttct  acatcattg  180
aatcaagtc  cctgacaca  ttgtgagaa  tatttatgc  ggaaatgct  tatgtacag  240
gaagtgtga  gagaaagtg  aagtgtttt  tgtccgtgg  acatccttt  atgctgcag  300
aacaagtgg  ggtagtgcc  gttcagaaa  ggcatcaag  acttcacca  tggaaatat  360
agagtggct  gaccagaaa  taacaaaaa  tgatcgacc  gagctaaca  gtgccaaag  420
ggtggtatc  ggtggtcga  gcttgaaga  tggagagaa  tttaagtgt  ttatatgac  480
tggcagatc  actacatgc  gcagtgggt  cttcccgtg  tgctgttga  gctggcttt  540
ttcccaatg  catgcaagt  ggcagacgg  aaaaatagt  gcaccagaa  tttatattg  600
tgttggata  ctgggagcc  tccaacatt  tagctggat  aacgacccg  cagaccatt  660
tggcaattg  ttaagaacc  agaagttcc  atttcccag  ggccgatat  ggtcgtgcg  720
ttatttagg  gtccggatg  ctggctttg  gagaactga  cggtctgct  gaaggaact  780
gtgggtccc  cgatcccat  gtggggttt  ccccttggg  cggggcgct  atgtgggcg  840
gtaccgccc  cgtggggcg  gcctccttg  ggccccttg  ccttcttcc  ctgcctaaa  900
ggcggctgc  g  911



<210> 6208
<211> 333
<212> PRT
<213> Homo sapiens
<308> P13804
<400> 6208

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
  1               5                  10                  15
Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
             20                  25                  30
Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Thr Arg Leu Gly 
         35                  40                  45
Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Ala 
     50                  55                  60
Gln Asp Leu Cys Lys Val Ala Gly Ile Ala Lys Val Leu Val Ala Gln 
 65                  70                  75                  80
His Asp Val Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                 85                  90                  95
Leu Ala Thr Gln Lys Gln Phe Asn Tyr Thr His Ile Cys Ala Gly Ala 
             100                105                110
Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Glu 
         115                120                125
Val Ala Pro Ile Ser Asp Ile Ile Ala Ile Lys Ser Pro Asp Thr Phe 
     130                135                140
Val Arg Thr Ile Tyr Ala Gly Asn Ala Leu Cys Thr Val Lys Cys Asp 
 145                150                155                160
Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Asp Ala Ala 
                 165                170                175
Ala Thr Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Ser Ser Thr Ser 
             180                185                190
Pro Val Glu Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
         195                200                205
Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
     210                215                220
Leu Lys Ser Gly Glu Asn Phe Lys Leu Leu Tyr Asp Leu Ala Asp Gln 
 225                230                235                240
Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                 245                250                255
Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
             260                265                270
Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
         275                280                285
Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
     290                295                300
Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
 305                310                315                320
Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                 325                330



<210> 6209
<211> 670
<212> DNA
<213> Rattus norvegicus
<308> AA894174
<400> 6209

ctgagaata  ttttaaagg  aggtgaaac  ttattatat  ttttattat  gaattagaa  60
atgtcaaaa  taattgttt  gaatcacaa  aaattaaaa  ggaatataa  aattgattc  120
tcaaaaggc  ttctagctg  tgttagcat  ttttctttc  ttggattat  aacttctat  180
atttcaact  aatactttt  acagtttcc  taagatatg  ttttgactt  ttttttctt  240
agtatttct  tcatttcag  aaccacctt  aataaatct  caactattc  ataatctgc  300
acttggaaa  ttggagctt  tgggtcttt  ttaatagcc  caattgtct  gctgtcctt  360
atcccagct  aatgctgga  ggctccaga  attccaaca  caatataaa  ttctggagc  420
actattttt  ctgtctgac  aacttgcat  tcattggga  caaagccag  atcaacagc  480
gcacgggaa  caccaactg  agcatgcag  tgatctgcc  agtcataca  cagtttaaa  540
ttctctcca  tcttcaagc  ccgaccacc  gataccacc  ctttggcac  agttagctc  600
ggtcggtca  tttttgtca  tttctggtc  agccactct  atattcctg  tgatgaaag  660
acttggtgcc  670



<210> 6210
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> AAA41130
<400> 6210

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
  1               5                  10                  15
Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
             20                  25                  30
Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Gly Arg Leu Gly 
         35                  40                  45
Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Val 
     50                  55                  60
Gln Asp Leu Cys Lys Val Ala Gly Val Ala Lys Val Leu Val Ala Gln 
 65                  70                  75                  80
His Asp Ala Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                 85                  90                  95
Leu Glu Thr Gln Lys Gln Phe Ser Tyr Thr His Ile Val Ala Gly Ala 
             100                105                110
Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Asn 
         115                120                125
Val Ala Pro Val Ser Asp Ile Ile Glu Ile Lys Ser Pro Asp Thr Phe 
     130                135                140
Val Arg Thr Ile Tyr Ala Ala Asn Ala Leu Cys Thr Val Lys Cys Asp 
 145                150                155                160
Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Glu Ala Ala 
                 165                170                175
Ala Ala Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Pro Ser Ser Ser 
             180                185                190
Ser Ala Gly Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
         195                200                205
Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
     210                215                220
Leu Lys Ser Gly Glu Asn Phe Lys Leu Gln Tyr Asp Leu Ala Asp Gln 
 225                230                235                240
Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                 245                250                255
Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
             260                265                270
Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
         275                280                285
Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
     290                295                300
Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
 305                310                315                320
Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                 325                330



<210> 6211
<211> 911
<212> DNA
<213> Homo sapiens
<308> BE535809
<400> 6211

tggtggctc  gcatgatgt  tacaaaggc  tacttccag  ggaactgac  ccattgatt  60
ggcaactca  aagcagttc  attacacac  catctgtgc  ggagcatct  ccttcggaa  120
gaacctttt  cccagagta  cagccaaac  tgaggttgc  ccgatttct  acatcattg  180
aatcaagtc  cctgacaca  ttgtgagaa  tatttatgc  ggaaatgct  tatgtacag  240
gaagtgtga  gagaaagtg  aagtgtttt  tgtccgtgg  acatccttt  atgctgcag  300
aacaagtgg  ggtagtgcc  gttcagaaa  ggcatcaag  acttcacca  tggaaatat  360
agagtggct  gaccagaaa  taacaaaaa  tgatcgacc  gagctaaca  gtgccaaag  420
ggtggtatc  ggtggtcga  gcttgaaga  tggagagaa  tttaagtgt  ttatatgac  480
tggcagatc  actacatgc  gcagtgggt  cttcccgtg  tgctgttga  gctggcttt  540
ttcccaatg  catgcaagt  ggcagacgg  aaaaatagt  gcaccagaa  tttatattg  600
tgttggata  ctgggagcc  tccaacatt  tagctggat  aacgacccg  cagaccatt  660
tggcaattg  ttaagaacc  agaagttcc  atttcccag  ggccgatat  ggtcgtgcg  720
ttatttagg  gtccggatg  ctggctttg  gagaactga  cggtctgct  gaaggaact  780
gtgggtccc  cgatcccat  gtggggttt  ccccttggg  cggggcgct  atgtgggcg  840
gtaccgccc  cgtggggcg  gcctccttg  ggccccttg  ccttcttcc  ctgcctaaa  900
ggcggctgc  g  911



<210> 6212
<211> 333
<212> PRT
<213> Homo sapiens
<308> P13804
<400> 6212

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
  1               5                  10                  15
Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
             20                  25                  30
Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Thr Arg Leu Gly 
         35                  40                  45
Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Ala 
     50                  55                  60
Gln Asp Leu Cys Lys Val Ala Gly Ile Ala Lys Val Leu Val Ala Gln 
 65                  70                  75                  80
His Asp Val Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                 85                  90                  95
Leu Ala Thr Gln Lys Gln Phe Asn Tyr Thr His Ile Cys Ala Gly Ala 
             100                105                110
Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Glu 
         115                120                125
Val Ala Pro Ile Ser Asp Ile Ile Ala Ile Lys Ser Pro Asp Thr Phe 
     130                135                140
Val Arg Thr Ile Tyr Ala Gly Asn Ala Leu Cys Thr Val Lys Cys Asp 
 145                150                155                160
Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Asp Ala Ala 
                 165                170                175
Ala Thr Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Ser Ser Thr Ser 
             180                185                190
Pro Val Glu Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
         195                200                205
Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
     210                215                220
Leu Lys Ser Gly Glu Asn Phe Lys Leu Leu Tyr Asp Leu Ala Asp Gln 
 225                230                235                240
Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                 245                250                255
Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
             260                265                270
Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
         275                280                285
Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
     290                295                300
Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
 305                310                315                320
Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                 325                330



<210> 6213
<211> 644
<212> DNA
<213> Rattus norvegicus
<308> AA894189
<400> 6213

gaaaaagga  tttagtagg  aatggagca  taaccatca  gaggaactg  cacttgaga  60
ttgtagaaa  atacctagg  gagatggtc  cctgaccta  ctaatttcc  ggtaggtgt  120
taggaattt  ggaagttgc  tcagcacct  agtcatgtg  tgcccctag  tgaggcact  180
ccccggcca  ccctccctg  aggcagctc  ctatgatgc  gatgctggc  cagtcgaac  240
cacagctct  tgcactcat  ggcactcaa  caaatgtca  aaaggagct  gaacgtgtg  300
agcatcagt  acggctgga  cagctgagc  cctctgaac  gcagagcaa  aacagagac  360
actgggaaa  ctggctaca  gaatacagg  aggcagccc  cagggtcat  tgtactggc  420
tcttgatac  atggccatc  tacaaggtg  ctgcagatg  ccccgaatt  ggggcatgg  480
acatgctgt  ctttggaaa  atttgattc  agagagcgt  tggacaagg  gaaggaggg  540
gtcggagac  ttgctgcct  gcaggcaga  cgtgtacgc  tcatgcatg  caacaaccc  600
aagtacgtc  taaagaact  tattgcaca  aaagccatt  aagc  644



<210> 6214
<211> 4135
<212> DNA
<213> Homo sapiens
<308> AL137665
<400> 6214

cacgagtac  tcagcttcc  agataagtc  tactggaca  atggctacg  gctcatctc  60
aaagaggtg  aggactgtg  tcccgtgtt  ctgaagcac  ttgcccacg  catatacgt  120
tgcggaaag  ccattaacc  gctgaagct  tgctgcccc  ggcattacc  ctgttggtc  180
gacgtccct  tcccccgga  ctcggtgat  ttctccctt  aggagttga  ggagattga  240
aaggactgt  ccgtctacg  tgggcgcat  gagagggtg  cccgccaca  ctctgtcag  300
aaggaggag  aggaattac  tatggaaat  gcaaaacaa  aattaatcg  tcatgcccg  360
gaagcagca  ccagggtcc  gagtgcact  agtgaccgg  agatgtcag  acggatggc  420
ttggatgcc  ggaagcgtg  gcagtttca  aggctgaaa  aacaatttg  gaaggacca  480
gagcgacgc  aggcggcca  gcaggagga  ctggatgat  acttcagct  cgcccgtga  540
ctccgagac  gggagagaa  gctgaagtc  ctggaggag  agctggaga  gaaggcgag  600
caggcactg  tcgaccact  cagcaagct  tctgcagag  cagctcgtc  ggagcagaa  660
gcactgtgg  gaatccaga  gcaccgact  gagagtgca  ggcttcgtt  tctcttaga  720
gatgagaaa  acattcagg  gatgctgaa  gcagtgtct  aggctcacc  gccccagga  780
ccgccagac  tcctcttga  cgtgcaccc  caggtcacg  ctccgggcc  tgagcaccc  840
gagggaggc  aaggctgtg  ttctgggtc  gcagagcaa  actcgcctg  ctgggatgg  900
tggaacagg  caggcctgc  gaccccaca  ccccttaag  ctctagcag  gggggctgg  960
ggcaggggg  tgcagcagg  ggagggggc  agacccttc  ctgacagcc  cagcattgg  1020
gacttccta  ctgtgggcc  aggggctga  ccgtccgtg  agactggca  ggtccctct  1080
ctggaggtg  cgctgcaga  cattaactt  gacctgccc  cctcagctc  tggggaggc  1140
cccgcagca  ccagcactc  gccctccag  ccacaggag  acgacttta  tactgtcct  1200
aggccagct  tggccacct  acctgcacc  gggcccctg  aggctgcag  gtgcagctt  1260
ggcagctca  ggctacagc  gtgggagga  agttgtggg  agatggatg  ctgtggctc  1320
gcctcgcgg  agactctgc  cccctcaca  ccacccagg  gtgctgctc  ggaggaggg  1380
agcagccag  ccacagagc  gctctttgg  caggtgtca  ggggtggtc  tcccacagg  1440
gactacgct  ctgaaatag  tcccacccg  ccacggtgg  acacccacg  gcacgtgtc  1500
gacgccagc  tcagggtcg  ggagaatgt  tcagatgtg  ctcccaccc  gccacggtg  1560
aacacccac  gacacgtat  caatgccag  atcagctta  gggagtctg  gtcagatgt  1620
gctcccact  ggccacggt  gaacatcca  ggacatgtg  ccaacgcca  catcagggt  1680
ggggagaat  tgtcagatg  ggctcccac  aggccacgg  ggaataccc  cgggcacgt  1740
tccaacgcc  gcatcaggg  tggggagaa  gtgtcggac  tggctccca  ccggccacg  1800
tggaacacc  atggacacg  gtccgatgc  agcatcagc  tgggggagt  tgtgtcaga  1860
atggctccc  cccggccac  gtggaacac  catggacac  tgtctgatg  cagcatcag  1920
ttgggggag  ctgtgtcag  catggctcc  acccggcca  ggtggaaca  ccacggaca  1980
gtgtctgac  ccagcatca  ggttgggga  aacgtatcg  acgtggctc  catccggtc  2040
cggtgcaac  cccatggac  cgtgtccga  gccagcatc  gcttggggg  gcctgtgtc  2100
gatgtggtt  ccacccggc  acggtggaa  acccatgta  ccatccctc  gccccacat  2160
gtgctgggg  ctctctcac  agaagctga  cccaacaca  ccaggcccc  acagagccc  2220
cctggccac  cgtcccagt  agcgctcag  ctgggagca  agagcactg  gctggactg  2280
gggccacgg  tgcctgtag  agtggggcc  tctctgtcc  cccccagct  gggctgcgg  2340
gaggggagc  tcagcgtgg  ggagaacgt  tcagacgtg  ctcccaccc  accatggtg  2400
cccaacacc  cgggagaca  tgtctctga  gaactaggt  agagtaggg  ggctggtgg  2460
caggagtgg  actgtggga  gcacagagc  tgggaggta  gcgggcagt  gggttggtg  2520
catgtgaag  tcccctcag  cctcctcgt  agccaggac  tgggctgct  tgggggaca  2580
gggaggggc  gcttgagcc  gggccggct  ggctccgta  ccgccacag  cactcggcc  2640
tgatgccct  gtgtccact  gtgtccaca  aggccctgg  aggagcggg  acgctgagg  2700
cctctctcc  aattggcct  tcaactcac  ggaagacac  gctgcccag  gcagcccag  2760
ccgtggtga  gaggcggag  catcggcgg  ggaggctca  ggtggggag  aggcctacc  2820
ggcaggcct  gcagggcag  accacttgg  gcggtaccc  gacagttac  agtccatgt  2880
cgagccgcc  attgctcat  ttttgcgcc  cgtgcttcc  cgggccttc  ccttccccg  2940
ggaccccca  gtccagtct  ccgctgatg  gactgctgt  cagctgagc  agttgctga  3000
gctgcccgt  ctcatgaag  gctccatca  ggcaccgct  gccgcccac  tctccttgg  3060
gaacaaggc  gctgtcgac  acttcttcg  ggagctgca  ctggaggcg  actatgagg  3120
actgcggca  ttcctgctg  tggaggacg  cgagttcgc  cagtccctc  gcgacctgc  3180
ctttgagaa  cttggagct  ggcaaacgc  cggagagct  ctcaacccg  tggtgctga  3240
ctctgtgct  agcaaggcc  tgcagtgca  cctgcatgg  gacaccccg  acgcctcca  3300
cctctccct  gctctcaag  acctgcccg  ggtgtttgc  cccaacgcc  cggatgtgc  3360
gagctgcct  gagctcagg  acaaggtgg  ctggcctct  aacattgtc  tcaccgagg  3420
ctgcctgag  aagtacagc  gcgtcttct  cttcctgct  cagctgaag  tcatgatgt  3480
ggcgctcaa  gacgtctgc  tccacctca  gcgcacagc  ctgctgagc  acatggccg  3540
ctctgtgca  ttccgtcag  tgcagctgt  caagcacga  atgcagcat  tcgtgaagg  3600
catccaggg  tacatcgcc  accagatcc  gcacgtcac  tggtgcgag  tcagggcca  3660
gttggccac  gtgggcgac  tggaggaga  ccagcgtgc  cacgcagag  acctgcaca  3720
ggccgtctt  aggggcctg  tcacggaga  ggcggcgcc  gtcatgaac  tcatccaca  3780
catcttcag  ctcgtgctc  agttccgca  ccagctcat  tcccaggcc  gggggcccc  3840
tgggggccc  cggggtgca  agcacccca  ctttgcact  atgcagcag  cctacaaca  3900
cttcaagta  tactcccac  ttctcttca  agtggtgac  aagctggtg  accgcggct  3960
ccagcccca  ctggaggac  ttctgctgc  catcaactt  aacaactac  accaggacg  4020
ctgaggctg  tctgcgggg  acgtgcaca  taaaggtgt  ctcggaaaa  aaaaaaaaa  4080
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  4135



<210> 6215
<211> 1819
<212> PRT
<213> Homo sapiens
<308> Q96RT7
<400> 6215

Met Ala Ser Ile Thr Gln Leu Phe Asp Asp Leu Cys Glu Ala Leu Leu 
  1               5                  10                  15
Pro Ala Ala Lys Thr His Leu Gly Gln Arg Ser Val Asn Arg Lys Arg 
             20                  25                  30
Ala Lys Arg Ser Leu Lys Lys Val Ala Tyr Asn Ala Leu Phe Thr Asn 
         35                  40                  45
Leu Phe Gln Asp Glu Thr Gln Gln Leu Gln Pro Asp Met Ser Lys Leu 
     50                  55                  60
Pro Ala Arg Asn Lys Ile Leu Met Leu Ser Phe Asp Leu Arg Val Gly 
 65                  70                  75                  80
Gly Leu Gly Pro Lys Ala Asp Arg Leu Glu Glu Leu Val Glu Glu Leu 
                 85                  90                  95
Glu Ala Ala Pro Cys Cys Pro Leu Leu Glu Val Gly Ser Val Leu Asp 
             100                105                110
Leu Leu Val Gln Leu Ala Gly Ser Gly Pro Pro Gln Val Leu Pro Arg 
         115                120                125
Lys Arg Asp Tyr Phe Leu Asn Asn Lys His Val Gly Arg Asn Val Pro 
     130                135                140
Tyr Ser Gly Tyr Asp Cys Asp Asp Leu Ser Val Phe Glu Met Asp Val 
 145                150                155                160
Gln Ser Leu Ile Ser Arg Glu Glu Cys Leu Cys His Ser Met Ile Gln 
                 165                170                175
Glu Thr Leu Gln Val Met Glu Ala Ala Pro Gly Thr Gly Leu Pro Thr 
             180                185                190
Val Gly Leu Phe Ser Phe Gly Asp Pro Cys Gly Asp Arg Phe Glu Arg 
         195                200                205
Asp Thr Arg Val Ser Leu Phe Gly Ala Leu Val His Ser Arg Thr Tyr 
     210                215                220
Asp Met Asp Val Arg Leu Gly Leu Pro Pro Val Pro Asp Asn Ala Asp 
 225                230                235                240
Leu Ser Gly Leu Ala Ile Lys Val Pro Pro Ser Val Asp Gln Trp Glu 
                 245                250                255
Asp Glu Gly Phe Gln Ser Ala Ser Asn Leu Thr Pro Asp Ser Gln Ser 
             260                265                270
Glu Pro Ser Val Thr Pro Asp Val Asp Leu Trp Glu Ala Ala Leu Thr 
         275                280                285
Tyr Glu Ala Ser Lys Arg Arg Cys Trp Glu Arg Val Gly Cys Pro Pro 
     290                295                300
Gly His Arg Glu Glu Pro Tyr Leu Thr Glu Ala Gly Arg Asp Ala Phe 
 305                310                315                320
Asp Lys Phe Cys Arg Leu His Gln Gly Glu Leu Gln Leu Leu Ala Gly 
                 325                330                335
Gly Val Leu Gln Ala Pro Gln Pro Val Leu Val Lys Glu Cys Glu Leu 
             340                345                350
Val Lys Asp Val Leu Asn Val Leu Ile Gly Val Val Ser Ala Thr Phe 
         355                360                365
Ser Leu Cys Gln Pro Ala Gln Ala Phe Val Val Lys Arg Gly Val His 
     370                375                380
Val Ser Gly Ala Ser Pro Glu Ser Ile Ser Ser Leu Leu Ser Glu Val 
 385                390                395                400
Ala Glu Tyr Gly Thr Cys Tyr Thr Arg Leu Ser His Phe Ser Leu Gln 
                 405                410                415
Pro Val Leu Asp Ser Leu Tyr Ser Lys Gly Leu Val Phe Gln Ala Phe 
             420                425                430
Thr Ser Gly Leu Arg Arg Tyr Leu Gln Tyr Tyr Arg Ala Cys Val Leu 
         435                440                445
Ser Thr Pro Pro Thr Leu Ser Leu Leu Thr Ile Gly Phe Leu Phe Lys 
     450                455                460
Lys Leu Gly Arg Gln Leu Arg Tyr Leu Ala Glu Leu Cys Gly Val Gly 
 465                470                475                480
Ala Val Leu Pro Gly Thr Cys Gly Gly Gly Pro Arg Ala Ala Phe Pro 
                 485                490                495
Thr Gly Val Lys Leu Leu Ser Tyr Leu Tyr Gln Glu Ala Leu His Asn 
             500                505                510
Cys Ser Asn Glu His Tyr Pro Val Leu Leu Ser Leu Leu Lys Thr Ser 
         515                520                525
Cys Glu Pro Tyr Thr Arg Phe Ile His Asp Trp Val Tyr Ser Gly Val 
     530                535                540
Phe Arg Asp Ala Tyr Gly Glu Phe Met Ile Gln Val Asn His Glu Tyr 
 545                550                555                560
Leu Ser Phe Arg Asp Lys Ser Tyr Trp Thr His Gly Tyr Val Leu Ile 
                 565                570                575
Ser Lys Glu Val Glu Asp Cys Val Pro Val Phe Leu Lys His Ile Ala 
             580                585                590
His Asp Ile Tyr Val Cys Gly Lys Thr Ile Asn Leu Leu Lys Leu Cys 
         595                600                605
Cys Pro Arg His Tyr Leu Cys Trp Ser Asp Val Pro Val Pro Arg Ile 
     610                615                620
Ser Val Ile Phe Ser Leu Glu Glu Leu Lys Glu Ile Glu Lys Asp Cys 
 625                630                635                640
Ala Val Tyr Val Gly Arg Met Glu Arg Val Ala Arg His Ser Ser Val 
                 645                650                655
Ser Lys Glu Glu Lys Glu Leu Arg Met Glu Ile Ala Lys Gln Glu Leu 
             660                665                670
Ile Ala His Ala Arg Glu Ala Ala Ser Arg Val Leu Ser Ala Leu Ser 
         675                680                685
Asp Arg Gln Met Ser Glu Arg Met Ala Leu Asp Ala Arg Lys Arg Glu 
     690                695                700
Gln Phe Gln Arg Leu Lys Glu Gln Phe Val Lys Asp Gln Glu Arg Arg 
 705                710                715                720
Gln Ala Ala Arg Gln Glu Glu Leu Asp Asp Asp Phe Ser Tyr Ala Arg 
                 725                730                735
Glu Leu Arg Asp Arg Glu Arg Arg Leu Lys Ser Leu Glu Glu Glu Leu 
             740                745                750
Glu Arg Lys Ala Arg Gln Ala Leu Val Asp His Tyr Ser Lys Leu Ser 
         755                760                765
Ala Glu Ala Ala Arg Arg Glu Gln Lys Ala Leu Trp Arg Ile Gln Arg 
     770                775                780
His Arg Leu Glu Ser Ala Arg Leu Arg Phe Leu Leu Glu Asp Glu Lys 
 785                790                795                800
His Ile Gln Glu Met Leu Lys Ala Val Ser Glu Ala His Gln Pro Gln 
                 805                810                815
Glu Pro Pro Asp Val Leu Leu Ser Val His Pro Gln Val Thr Ser Pro 
             820                825                830
Gly Pro Glu His Pro Glu Gly Gly Gln Gly Cys Asp Ser Gly Ser Ala 
         835                840                845
Glu Gln His Ser Pro Ala Trp Asp Gly Trp Asn Arg Pro Gly Leu Leu 
     850                855                860
Thr Pro Gln Pro Leu Lys Pro Leu Ala Val Gly Ala Gly Gly Arg Gly 
 865                870                875                880
Leu Gln Gln Ala Glu Gly Ala Arg Pro Phe Ser Asp Ser Leu Ser Ile 
                 885                890                895
Gly Asp Phe Leu Pro Val Gly Pro Gly Ala Glu Pro Ser Val Gln Thr 
             900                905                910
Gly Met Val Pro Leu Leu Glu Val Ala Leu Gln Thr Ile Asn Leu Asp 
         915                920                925
Leu Pro Pro Ser Ala Pro Gly Glu Ala Pro Ala Ala Ala Ser Thr Gln 
     930                935                940
Pro Ser Arg Pro Gln Glu Tyr Asp Phe Ser Thr Val Leu Arg Pro Ala 
 945                950                955                960
Val Ala Thr Ser Pro Ala Pro Gly Pro Leu Gln Ala Ala Glu Cys Ser 
                 965                970                975
Leu Gly Ser Ser Gly Leu Gln Leu Trp Glu Asp Ser Cys Gly Lys Met 
             980                985                990
Asp Ala Cys Gly Ser Ala Ser Arg Glu Thr Leu Leu Pro Ser His Pro 
         995                1000                1005
Pro Arg Arg Ala Ala Leu Glu Glu Gly Ser Ser Gln Pro Thr Glu Arg 
     1010                1015                1020
Leu Phe Gly Gln Val Ser Gly Gly Gly Leu Pro Thr Gly Asp Tyr Ala 
 1025                1030                1035                1040
Ser Glu Ile Ala Pro Thr Arg Pro Arg Trp Asn Thr His Gly His Val 
                 1045                1050                1055
Ser Asp Ala Ser Ile Arg Val Gly Glu Asn Val Ser Asp Val Ala Pro 
             1060                1065                1070
Thr Gln Pro Arg Trp Asn Thr His Gly His Val Ser Asn Ala Ser Ile 
         1075                1080                1085
Ser Leu Gly Glu Ser Val Ser Asp Val Ala Pro Thr Arg Pro Arg Trp 
     1090                1095                1100
Asn Ile His Gly His Val Ser Asn Ala Ser Ile Arg Val Gly Glu Asn 
 1105                1110                1115                1120
Val Ser Asp Val Ala Pro Thr Arg Pro Arg Trp Asn Thr His Gly His 
                 1125                1130                1135
Val Ser Asn Ala Ser Ile Arg Val Gly Glu Asn Val Ser Asp Val Ala 
             1140                1145                1150
Pro Thr Arg Pro Arg Trp Asn Thr His Gly His Val Ser Asp Ala Ser 
         1155                1160                1165
Ile Ser Leu Gly Glu Ser Val Ser Asp Met Ala Pro Ala Arg Pro Arg 
     1170                1175                1180
Trp Asn Thr His Gly His Val Ser Asp Ala Ser Ile Ser Leu Gly Glu 
 1185                1190                1195                1200
Ser Val Ser Asp Met Ala Pro Thr Arg Pro Arg Trp Asn Thr His Gly 
                 1205                1210                1215
His Val Ser Asp Thr Ser Ile Arg Val Gly Glu Asn Val Ser Asp Val 
             1220                1225                1230
Ala Pro Ile Arg Ser Arg Cys Asn Thr His Gly His Val Ser Asp Ala 
         1235                1240                1245
Ser Ile Ser Leu Gly Glu Pro Val Ser Asp Val Val Ser Thr Arg Pro 
     1250                1255                1260
Arg Trp Asn Thr His Val Pro Ile Pro Pro Pro His Met Val Leu Gly 
 1265                1270                1275                1280
Ala Leu Ser Pro Glu Ala Glu Pro Asn Thr Pro Arg Pro Gln Gln Ser 
                 1285                1290                1295
Pro Pro Gly His Thr Ser Gln Ser Ala Leu Ser Leu Gly Ala Gln Ser 
             1300                1305                1310
Thr Val Leu Asp Cys Gly Pro Arg Leu Pro Val Glu Val Gly Pro Ser 
         1315                1320                1325
Leu Ser Ser Pro Ser Ser Gly Cys Gly Glu Gly Ser Ile Ser Val Gly 
     1330                1335                1340
Glu Asn Val Ser Asp Val Ala Pro Thr Gln Pro Trp Trp Pro Asn Thr 
 1345                1350                1355                1360
Pro Gly Asp Ser Val Ser Glu Glu Leu Gly Pro Gly Arg Ser Gly Asp 
                 1365                1370                1375
Ala Glu Asp Leu Ser Pro Asn Trp Pro Leu Asn Ser Gln Glu Asp Thr 
             1380                1385                1390
Ala Ala Gln Ser Ser Pro Gly Arg Gly Glu Glu Ala Glu Ala Ser Ala 
         1395                1400                1405
Ala Glu Ala Gln Gly Gly Glu Gln Ala Tyr Leu Ala Gly Leu Ala Gly 
     1410                1415                1420
Gln Tyr His Leu Glu Arg Tyr Pro Asp Ser Tyr Glu Ser Met Ser Glu 
 1425                1430                1435                1440
Pro Pro Ile Ala His Leu Leu Arg Pro Val Leu Pro Arg Ala Phe Ala 
                 1445                1450                1455
Phe Pro Val Asp Pro Gln Val Gln Ser Ala Ala Asp Glu Thr Ala Val 
             1460                1465                1470
Gln Leu Ser Glu Leu Leu Thr Leu Pro Val Leu Met Lys Arg Ser Ile 
         1475                1480                1485
Thr Ala Pro Leu Ala Ala His Ile Ser Leu Val Asn Lys Ala Ala Val 
     1490                1495                1500
Asp Tyr Phe Phe Val Glu Leu His Leu Glu Ala His Tyr Glu Ala Leu 
 1505                1510                1515                1520
Arg His Phe Leu Leu Met Glu Asp Gly Glu Phe Ala Gln Ser Leu Ser 
                 1525                1530                1535
Asp Leu Leu Phe Glu Lys Leu Gly Ala Gly Gln Thr Pro Gly Glu Leu 
             1540                1545                1550
Leu Asn Pro Leu Val Leu Asn Ser Val Leu Ser Lys Ala Leu Gln Cys 
         1555                1560                1565
Ser Leu His Gly Asp Thr Pro His Ala Ser Asn Leu Ser Leu Ala Leu 
     1570                1575                1580
Lys Tyr Leu Pro Glu Val Phe Ala Pro Asn Ala Pro Asp Val Leu Ser 
 1585                1590                1595                1600
Cys Leu Glu Leu Arg Tyr Lys Val Asp Trp Pro Leu Asn Ile Val Ile 
                 1605                1610                1615
Thr Glu Gly Cys Leu Ser Lys Tyr Ser Gly Val Phe Ser Phe Leu Leu 
             1620                1625                1630
Gln Leu Lys Leu Met Met Trp Ala Leu Lys Asp Val Cys Phe His Leu 
         1635                1640                1645
Lys Arg Thr Ala Leu Leu Ser His Met Ala Gly Ser Val Gln Phe Arg 
     1650                1655                1660
Gln Leu Gln Leu Phe Lys His Glu Met Gln His Phe Val Lys Val Ile 
 1665                1670                1675                1680
Gln Gly Tyr Ile Ala Asn Gln Ile Leu His Val Thr Trp Cys Glu Phe 
                 1685                1690                1695
Arg Ala Arg Leu Ala Thr Val Gly Asp Leu Glu Glu Ile Gln Arg Ala 
             1700                1705                1710
His Ala Glu Tyr Leu His Lys Ala Val Phe Arg Gly Leu Leu Thr Glu 
         1715                1720                1725
Lys Ala Ala Pro Val Met Asn Val Ile His Ser Ile Phe Ser Leu Val 
     1730                1735                1740
Leu Lys Phe Arg Ser Gln Leu Ile Ser Gln Ala Trp Gly Pro Pro Gly 
 1745                1750                1755                1760
Gly Pro Arg Gly Ala Glu His Pro Asn Phe Ala Leu Met Gln Gln Ser 
                 1765                1770                1775
Tyr Asn Thr Phe Lys Tyr Tyr Ser His Phe Leu Phe Lys Val Val Thr 
             1780                1785                1790
Lys Leu Val Asn Arg Gly Tyr Gln Pro His Leu Glu Asp Phe Leu Leu 
         1795                1800                1805
Arg Ile Asn Phe Asn Asn Tyr Tyr Gln Asp Ala 
     1810                1815



<210> 6216
<211> 584
<212> DNA
<213> Rattus norvegicus
<308> AA894193
<400> 6216

tgattttat  gagatttac  tacaggagt  tcaataagg  attacttac  ggaataagg  60
tgactcaaa  tcagttgca  caccaaaaa  tacactgag  aggggtgac  actcaaaaa  120
cttcaaccc  gtagctgct  ctcacacaa  tttcaggcc  tcataatag  taaaaaatt  180
aagtacttc  ttatcttat  atttctttt  tatacttat  catatgaat  aagttagag  240
agaaaagag  gagattata  tacatagaa  atgaaatcc  gagaatgat  tgaggattc  300
ttgaaaaca  acaataaac  ggaaaatcg  gaagaattt  aagacatat  tgaaatatc  360
aaattaggc  aaagttgga  gtttcacaa  cctccccct  cacatatca  aggctattg  420
gattgttct  ggttaccac  cagaacttg  cagtaagac  ttattactg  aaacaccac  480
catcaagtc  tagagcaat  aggaaatca  agcttatac  gccctagaa  cttcatcct  540
ctggctagc  gtcatagtg  tagatgatg  tgtgcatgc  acca  584



<210> 6217
<211> 555
<212> DNA
<213> Rattus norvegicus
<308> AA894199
<400> 6217

cggagctgg  gaccgaacc  agggccttg  acttcctag  caagcgctc  accgctgag  60
taaatcccc  accccatac  tgtcacttt  aagacaatt  ttatgttca  gaatccaaa  120
gaccatcac  caaaacacc  ggcacttgt  aaggccatc  gtaaccaga  ccatgttgg  180
atcttgctt  tacctcagt  tagttcctt  aaaaaacaa  ctacattcc  agataaagc  240
gacataaac  cactaggag  atctgtgcc  ctgcctcta  tctagggag  gagttttct  300
tcaagcaca  agctcgcta  tctaactat  cttctggat  agtgttatc  gatcatgta  360
ggcagcata  acctaatca  agttagaat  aaattaagt  gtgtggatt  cttaattta  420
agtacttgt  tgacaatca  gtcacacaa  tgactgtat  attagtctt  ctcaatgtt  480
tgaaatgac  tcgaacaag  aagatctgt  tttatatga  caatgccag  aatgcttct  540
cctctttct  ccatc  555



<210> 6218
<211> 630
<212> DNA
<213> Rattus norvegicus
<308> AA894207
<400> 6218

aatggagtg  gctggatgt  tctacagtt  tgttcagat  actacagaa  ctggaaaag  60
tgttgctgc  gttgatgca  aacacactg  tattattgg  ctttttata  aaatataaa  120
atatatata  agataaata  tttgaattt  ttgaaactt  acctgtgct  tcaactttg  180
aaaaaagta  ccccgttta  tgtgttgag  tggcactgt  aagaaatta  cagccatat  240
ggtctagaa  tgttgaact  gagtttttt  catttgtac  ggggtaaca  actgtatta  300
atatgtaag  tcttatcta  gtgggtttg  ttacaaaaa  taataaagt  ttctctaaa  360
taaaaaaaa  gatgtatgt  tactaaggg  tgagtcaca  cactagaaa  agttttttt  420
taaaataaa  aacttaatc  tggggttca  attgagatc  aatatccta  aacaggtcg  480
tttccaata  ttcctcaag  cgtcaagta  cgactagct  ctttccagc  atccagctc  540
gctctgatg  catgtacct  gagaccaca  cacagattc  cagaagcag  gtgagggtt  600
agcctanag  agtgcccct  tacctctgac  630



<210> 6219
<211> 618
<212> PRT
<213> Rattus norvegicus
<308> AAF17574
<400> 6219

Met Ser Gln Leu Ser Ser Thr Leu Lys Arg Tyr Thr Glu Ser Ser Arg 
  1               5                  10                  15
Tyr Thr Asp Ala Pro Tyr Ala Lys Ser Gly Tyr Gly Thr Tyr Thr Pro 
             20                  25                  30
Ser Ser Tyr Gly Ala Asn Leu Ala Ala Ser Phe Leu Glu Lys Glu Lys 
         35                  40                  45
Leu Gly Phe Lys Pro Val Ser Pro Thr Ser Phe Leu Pro Arg Pro Arg 
     50                  55                  60
Thr Tyr Gly Pro Ser Ser Ile Leu Asp Cys Asp Arg Gly Arg Pro Leu 
 65                  70                  75                  80
Leu Arg Ser Asp Ile Thr Gly Gly Ser Lys Arg Ser Glu Ser Gln Thr 
                 85                  90                  95
Arg Gly Asn Glu Arg Pro Ser Gly Ser Gly Leu Asn Gly Gly Ser Gly 
             100                105                110
Phe Pro Tyr Gly Val Thr Ser Asn Ser Leu Ser Tyr Leu Pro Met Asn 
         115                120                125
Ala Arg Asp Gln Gly Val Thr Leu Gly Gln Lys Lys Ser Asn Ser Gln 
     130                135                140
Ser Asp Leu Ala Arg Asp Phe Ser Ser Leu Arg Thr Ser Asp Ser Tyr 
 145                150                155                160
Arg Thr Ser Asp Gly Tyr Arg Ala Ser Asp Gly Ser Arg Ile Asp Pro 
                 165                170                175
Gly Asn Leu Gly Arg Ser Pro Met Leu Ala Arg Thr Arg Lys Glu Leu 
             180                185                190
Cys Ala Leu Gln Gly Leu Tyr Gln Ala Ala Ser Arg Ser Glu Tyr Leu 
         195                200                205
Thr Asp Tyr Leu Glu Asn Tyr Gly Arg Lys Gly Ser Ala Pro Gln Val 
     210                215                220
Leu Thr Gln Ala Pro Pro Ser Arg Val Pro Glu Val Leu Ser Pro Thr 
 225                230                235                240
Tyr Arg Pro Ser Gly Arg Tyr Thr Leu Trp Glu Lys Asn Lys Gly Gln 
                 245                250                255
Ala Ser Gly Ala Ser Arg Ser Thr Ser Pro Gly Arg Asp Thr Met Asn 
             260                265                270
Ser Lys Ser Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly Asn Thr 
         275                280                285
Cys Phe Met Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg Glu Leu 
     290                295                300
Arg Asp Tyr Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu Gly His Thr 
 305                310                315                320
Ser Ser Ala His Thr Ala Leu Met Glu Glu Phe Ala Lys Leu Ile Gln 
                 325                330                335
Thr Ile Trp Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser Glu Phe 
             340                345                350
Lys Thr Gln Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr Asn Gln 
         355                360                365
Gln Asp Ala Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu His Asn 
     370                375                380
Glu Val Asn Arg Val Ala Ala Arg Pro Lys Pro Ser Pro Glu Ser Leu 
 385                390                395                400
Asp His Leu Pro Asp Glu Glu Lys Gly Arg Gln Met Trp Arg Lys Tyr 
                 405                410                415
Leu Glu Arg Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly Gln Leu 
             420                425                430
Lys Ser Ser Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr Val Phe 
         435                440                445
Asp Pro Phe Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly Tyr Pro 
     450                455                460
Glu Val Thr Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu Asp Val 
 465                470                475                480
Leu Asp Gly Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Ala Arg Lys 
                 485                490                495
Arg Cys Ile Lys Lys Phe Ser Val Gln Arg Phe Pro Lys Ile Leu Val 
             500                505                510
Leu His Leu Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser Lys Leu 
         515                520                525
Thr Thr Phe Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg Glu Phe 
     530                535                540
Ala Ser Glu Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala Val Ser 
 545                550                555                560
Asn His Ser Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr Cys Arg 
                 565                570                575
Ser Pro Val Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser Val Thr 
             580                585                590
Pro Met Ser Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu Leu Phe 
         595                600                605
Tyr Glu Leu Ala Ser Pro Pro Ser Arg Met 
     610                615



<210> 6220
<211> 2307
<212> DNA
<213> Homo sapiens
<308> AJ006470
<400> 6220

ggcacgagg  gatggagcc  gggcgccgg  gggccgcgg  gctgctagc  ctgctgtgc  60
tggcctgcg  gctgcgcgc  gggcgcgcc  aatacgaac  ctacagctt  cgcagcttc  120
cacgggacg  gctgatgcc  ctcgagtcg  cctaccggc  cgcgctgga  aagtacagc  180
gcgagcact  ggccgagag  gtgggctac  tggagatca  cctgcggct  caccgcttg  240
tgcgcgaca  cgaggcctt  tgccaccgc  actgcagcg  cgcgccgca  cccgagccc  300
ccgccggcc  cgccagcta  cccgagctg  gcctcttcg  gggcctgct  cgccgcgcg  360
actgcctca  gcgctgcaa  cagggcctg  cagccttcc  ccagtccca  cccagccgc  420
aggtgctgg  ggacttcca  cgccgcgag  cctacaagt  cctgcagtt  gcttacttc  480
aggcaaata  tctccccaa  gccatcgcc  ctgctcaca  ctttctact  aagcatcct  540
atgacgaaa  gatgaagag  aacatggca  attataaga  cctgcctgg  gccgaggac  600
acattaaag  cctggaaac  aagtcatat  aaagcctgt  catccgagc  gtgcgggca  660
acaacggtg  gaactggag  acatccatc  cagacatgg  gctggccct  cccgacttc  720
tcaaagcct  ttacgagtg  ctcgcagcc  gcgagggtt  cagggagat  aaggacttc  780
aggatttct  cctttccat  gcagatcat  atgtagaag  tctggaatg  aaaatacag  840
gtgaagaga  cctcacccc  gttatagga  gctatccgg  tgagaaatt  gtggctacc  900
tgtatcatt  cttgcagtt  gcctattat  agttgaacg  cctgaagaa  gcagccccc  960
gtgcagtca  ctatctgct  tttgatcag  atgacaagg  catgcagca  aacctggtg  1020
attaccagt  ccacaggga  acttggggc  tctcggatg  gcacttcca  cccagacct  1080
aagcagttc  gttctttaa  gtgaccaca  tccagaagg  gctgtatga  tttgctaag  1140
aaaatataa  ggatgatga  gagggagaa  ttgtggaat  tgtggatga  ctcttggaa  1200
tggaggaga  cagctagcc  acagcaacc  aagagactt  ctcttggcg  tcaggaaac  1260
cagattctt  gtccttttc  caacagccc  ggctgttga  acctcagag  cttctcttt  1320
ctctccaaa  tgaaaggga  gcccccgtc  ctctaactg  atgtcatca  gggtgagcc  1380
gcctttcct  tcttcacac  tgccacctc  tgttcacac  tatctttct  acctttttt  1440
tgagatgga  tctcgctct  ttgcccagg  tggagtgca  tggcacgtt  tcagctcac  1500
gcaacctcc  cctcttggg  tcaagcaat  ctgctgcat  agcctcccg  gtacctggg  1560
ttacaggca  gtgccacca  gcccggcta  ttttgtatt  ttaagtaag  gacggggtt  1620
tgccatgtt  gccaggctg  tctcgaact  ttgacttca  atgatccat  tgccttggg  1680
ctcccacag  gctgggatt  caggcgtga  ccaccatgc  cggcctctt  ctcaccttt  1740
cacctgtct  cttatcctc  catctgttt  cacaccttc  tccctgtct  cctcatgtt  1800
acacttgtc  tccccatgt  catagctgc  tttcttacc  ttttggttt  aagggcagt  1860
ttctctggc  tgttttttt  tttttccca  aaaatcagt  ttatttttt  aataagaaa  1920
acattccta  aagatgata  ttgtgaaaa  ctcctttgg  ttatttgct  ttccagatt  1980
tagtctcct  tctccccat  cgggaaaga  kgtggaaga  ataggctaa  tttctccag  2040
ctcacaatg  tcttcactt  gtctgactt  taccaattc  agcacccac  gaaaaacaa  2100
ttgagtaga  agtgtagag  gcagaaatg  ggcttttgc  ccactttgc  tctccaaaa  2160
tacaacggt  ggccgatcn  aattgagga  aatgnttag  tataagtct  cgagttgga  2220
aaggaagaa  gccagagct  tctagtttc  ttcattctt  cagtaaata  ttattgagt  2280
aaaaaaaaa  aaaaaaaaa  aaaaaaa  2307



<210> 6221
<211> 401
<212> PRT
<213> Homo sapiens
<308> O75718
<400> 6221

Met Glu Pro Gly Arg Arg Gly Ala Ala Ala Leu Leu Ala Leu Leu Cys 
  1               5                  10                  15
Val Ala Cys Ala Leu Arg Ala Gly Arg Ala Gln Tyr Glu Arg Tyr Ser 
             20                  25                  30
Phe Arg Ser Phe Pro Arg Asp Glu Leu Met Pro Leu Glu Ser Ala Tyr 
         35                  40                  45
Arg His Ala Leu Asp Lys Tyr Ser Gly Glu His Trp Ala Glu Ser Val 
     50                  55                  60
Gly Tyr Leu Glu Ile Ser Leu Arg Leu His Arg Leu Leu Arg Asp Ser 
 65                  70                  75                  80
Glu Ala Phe Cys His Arg Asn Cys Ser Ala Ala Pro Gln Pro Glu Pro 
                 85                  90                  95
Ala Ala Gly Leu Ala Ser Tyr Pro Glu Leu Arg Leu Phe Gly Gly Leu 
             100                105                110
Leu Arg Arg Ala His Cys Leu Lys Arg Cys Lys Gln Gly Leu Pro Ala 
         115                120                125
Phe Arg Gln Ser Gln Pro Ser Arg Glu Val Leu Ala Asp Phe Gln Arg 
     130                135                140
Arg Glu Pro Tyr Lys Phe Leu Gln Phe Ala Tyr Phe Lys Ala Asn Asn 
 145                150                155                160
Leu Pro Lys Ala Ile Ala Ala Ala His Thr Phe Leu Leu Lys His Pro 
                 165                170                175
Asp Asp Glu Met Met Lys Arg Asn Met Ala Tyr Tyr Lys Ser Leu Pro 
             180                185                190
Gly Ala Glu Asp Tyr Ile Lys Asp Leu Glu Thr Lys Ser Tyr Glu Ser 
         195                200                205
Leu Phe Ile Arg Ala Val Arg Ala Tyr Asn Gly Glu Asn Trp Arg Thr 
     210                215                220
Ser Ile Thr Asp Met Glu Leu Ala Leu Pro Asp Phe Phe Lys Ala Phe 
 225                230                235                240
Tyr Glu Cys Leu Ala Ala Cys Glu Gly Ser Arg Glu Ile Lys Asp Phe 
                 245                250                255
Lys Asp Phe Tyr Leu Ser Ile Ala Asp His Tyr Val Glu Val Leu Glu 
             260                265                270
Cys Lys Ile Gln Cys Glu Glu Asn Leu Thr Pro Val Ile Gly Gly Tyr 
         275                280                285
Pro Val Glu Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala 
     290                295                300
Tyr Tyr Lys Leu Asn Asp Leu Lys Asn Ala Ala Pro Cys Ala Val Ser 
 305                310                315                320
Tyr Leu Leu Phe Asp Gln Asn Asp Lys Val Met Gln Gln Asn Leu Val 
                 325                330                335
Tyr Tyr Gln Tyr His Arg Asp Thr Trp Gly Leu Ser Asp Glu His Phe 
             340                345                350
Gln Pro Arg Pro Glu Ala Val Gln Phe Phe Asn Val Thr Thr Leu Gln 
         355                360                365
Lys Glu Leu Tyr Asp Phe Ala Lys Glu Asn Ile Met Asp Asp Asp Glu 
     370                375                380
Gly Glu Val Val Glu Tyr Val Asp Asp Leu Leu Glu Leu Glu Glu Thr 
 385                390                395                400
Ser 
                 405



<210> 6222
<211> 630
<212> DNA
<213> Rattus norvegicus
<308> AA894207
<400> 6222

aatggagtg  gctggatgt  tctacagtt  tgttcagat  actacagaa  ctggaaaag  60
tgttgctgc  gttgatgca  aacacactg  tattattgg  ctttttata  aaatataaa  120
atatatata  agataaata  tttgaattt  ttgaaactt  acctgtgct  tcaactttg  180
aaaaaagta  ccccgttta  tgtgttgag  tggcactgt  aagaaatta  cagccatat  240
ggtctagaa  tgttgaact  gagtttttt  catttgtac  ggggtaaca  actgtatta  300
atatgtaag  tcttatcta  gtgggtttg  ttacaaaaa  taataaagt  ttctctaaa  360
taaaaaaaa  gatgtatgt  tactaaggg  tgagtcaca  cactagaaa  agttttttt  420
taaaataaa  aacttaatc  tggggttca  attgagatc  aatatccta  aacaggtcg  480
tttccaata  ttcctcaag  cgtcaagta  cgactagct  ctttccagc  atccagctc  540
gctctgatg  catgtacct  gagaccaca  cacagattc  cagaagcag  gtgagggtt  600
agcctanag  agtgcccct  tacctctgac  630



<210> 6223
<211> 618
<212> PRT
<213> Rattus norvegicus
<308> AAF17574
<400> 6223

Met Ser Gln Leu Ser Ser Thr Leu Lys Arg Tyr Thr Glu Ser Ser Arg 
  1               5                  10                  15
Tyr Thr Asp Ala Pro Tyr Ala Lys Ser Gly Tyr Gly Thr Tyr Thr Pro 
             20                  25                  30
Ser Ser Tyr Gly Ala Asn Leu Ala Ala Ser Phe Leu Glu Lys Glu Lys 
         35                  40                  45
Leu Gly Phe Lys Pro Val Ser Pro Thr Ser Phe Leu Pro Arg Pro Arg 
     50                  55                  60
Thr Tyr Gly Pro Ser Ser Ile Leu Asp Cys Asp Arg Gly Arg Pro Leu 
 65                  70                  75                  80
Leu Arg Ser Asp Ile Thr Gly Gly Ser Lys Arg Ser Glu Ser Gln Thr 
                 85                  90                  95
Arg Gly Asn Glu Arg Pro Ser Gly Ser Gly Leu Asn Gly Gly Ser Gly 
             100                105                110
Phe Pro Tyr Gly Val Thr Ser Asn Ser Leu Ser Tyr Leu Pro Met Asn 
         115                120                125
Ala Arg Asp Gln Gly Val Thr Leu Gly Gln Lys Lys Ser Asn Ser Gln 
     130                135                140
Ser Asp Leu Ala Arg Asp Phe Ser Ser Leu Arg Thr Ser Asp Ser Tyr 
 145                150                155                160
Arg Thr Ser Asp Gly Tyr Arg Ala Ser Asp Gly Ser Arg Ile Asp Pro 
                 165                170                175
Gly Asn Leu Gly Arg Ser Pro Met Leu Ala Arg Thr Arg Lys Glu Leu 
             180                185                190
Cys Ala Leu Gln Gly Leu Tyr Gln Ala Ala Ser Arg Ser Glu Tyr Leu 
         195                200                205
Thr Asp Tyr Leu Glu Asn Tyr Gly Arg Lys Gly Ser Ala Pro Gln Val 
     210                215                220
Leu Thr Gln Ala Pro Pro Ser Arg Val Pro Glu Val Leu Ser Pro Thr 
 225                230                235                240
Tyr Arg Pro Ser Gly Arg Tyr Thr Leu Trp Glu Lys Asn Lys Gly Gln 
                 245                250                255
Ala Ser Gly Ala Ser Arg Ser Thr Ser Pro Gly Arg Asp Thr Met Asn 
             260                265                270
Ser Lys Ser Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly Asn Thr 
         275                280                285
Cys Phe Met Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg Glu Leu 
     290                295                300
Arg Asp Tyr Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu Gly His Thr 
 305                310                315                320
Ser Ser Ala His Thr Ala Leu Met Glu Glu Phe Ala Lys Leu Ile Gln 
                 325                330                335
Thr Ile Trp Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser Glu Phe 
             340                345                350
Lys Thr Gln Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr Asn Gln 
         355                360                365
Gln Asp Ala Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu His Asn 
     370                375                380
Glu Val Asn Arg Val Ala Ala Arg Pro Lys Pro Ser Pro Glu Ser Leu 
 385                390                395                400
Asp His Leu Pro Asp Glu Glu Lys Gly Arg Gln Met Trp Arg Lys Tyr 
                 405                410                415
Leu Glu Arg Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly Gln Leu 
             420                425                430
Lys Ser Ser Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr Val Phe 
         435                440                445
Asp Pro Phe Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly Tyr Pro 
     450                455                460
Glu Val Thr Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu Asp Val 
 465                470                475                480
Leu Asp Gly Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Ala Arg Lys 
                 485                490                495
Arg Cys Ile Lys Lys Phe Ser Val Gln Arg Phe Pro Lys Ile Leu Val 
             500                505                510
Leu His Leu Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser Lys Leu 
         515                520                525
Thr Thr Phe Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg Glu Phe 
     530                535                540
Ala Ser Glu Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala Val Ser 
 545                550                555                560
Asn His Ser Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr Cys Arg 
                 565                570                575
Ser Pro Val Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser Val Thr 
             580                585                590
Pro Met Ser Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu Leu Phe 
         595                600                605
Tyr Glu Leu Ala Ser Pro Pro Ser Arg Met 
     610                615



<210> 6224
<211> 2307
<212> DNA
<213> Homo sapiens
<308> AJ006470
<400> 6224

ggcacgagg  gatggagcc  gggcgccgg  gggccgcgg  gctgctagc  ctgctgtgc  60
tggcctgcg  gctgcgcgc  gggcgcgcc  aatacgaac  ctacagctt  cgcagcttc  120
cacgggacg  gctgatgcc  ctcgagtcg  cctaccggc  cgcgctgga  aagtacagc  180
gcgagcact  ggccgagag  gtgggctac  tggagatca  cctgcggct  caccgcttg  240
tgcgcgaca  cgaggcctt  tgccaccgc  actgcagcg  cgcgccgca  cccgagccc  300
ccgccggcc  cgccagcta  cccgagctg  gcctcttcg  gggcctgct  cgccgcgcg  360
actgcctca  gcgctgcaa  cagggcctg  cagccttcc  ccagtccca  cccagccgc  420
aggtgctgg  ggacttcca  cgccgcgag  cctacaagt  cctgcagtt  gcttacttc  480
aggcaaata  tctccccaa  gccatcgcc  ctgctcaca  ctttctact  aagcatcct  540
atgacgaaa  gatgaagag  aacatggca  attataaga  cctgcctgg  gccgaggac  600
acattaaag  cctggaaac  aagtcatat  aaagcctgt  catccgagc  gtgcgggca  660
acaacggtg  gaactggag  acatccatc  cagacatgg  gctggccct  cccgacttc  720
tcaaagcct  ttacgagtg  ctcgcagcc  gcgagggtt  cagggagat  aaggacttc  780
aggatttct  cctttccat  gcagatcat  atgtagaag  tctggaatg  aaaatacag  840
gtgaagaga  cctcacccc  gttatagga  gctatccgg  tgagaaatt  gtggctacc  900
tgtatcatt  cttgcagtt  gcctattat  agttgaacg  cctgaagaa  gcagccccc  960
gtgcagtca  ctatctgct  tttgatcag  atgacaagg  catgcagca  aacctggtg  1020
attaccagt  ccacaggga  acttggggc  tctcggatg  gcacttcca  cccagacct  1080
aagcagttc  gttctttaa  gtgaccaca  tccagaagg  gctgtatga  tttgctaag  1140
aaaatataa  ggatgatga  gagggagaa  ttgtggaat  tgtggatga  ctcttggaa  1200
tggaggaga  cagctagcc  acagcaacc  aagagactt  ctcttggcg  tcaggaaac  1260
cagattctt  gtccttttc  caacagccc  ggctgttga  acctcagag  cttctcttt  1320
ctctccaaa  tgaaaggga  gcccccgtc  ctctaactg  atgtcatca  gggtgagcc  1380
gcctttcct  tcttcacac  tgccacctc  tgttcacac  tatctttct  acctttttt  1440
tgagatgga  tctcgctct  ttgcccagg  tggagtgca  tggcacgtt  tcagctcac  1500
gcaacctcc  cctcttggg  tcaagcaat  ctgctgcat  agcctcccg  gtacctggg  1560
ttacaggca  gtgccacca  gcccggcta  ttttgtatt  ttaagtaag  gacggggtt  1620
tgccatgtt  gccaggctg  tctcgaact  ttgacttca  atgatccat  tgccttggg  1680
ctcccacag  gctgggatt  caggcgtga  ccaccatgc  cggcctctt  ctcaccttt  1740
cacctgtct  cttatcctc  catctgttt  cacaccttc  tccctgtct  cctcatgtt  1800
acacttgtc  tccccatgt  catagctgc  tttcttacc  ttttggttt  aagggcagt  1860
ttctctggc  tgttttttt  tttttccca  aaaatcagt  ttatttttt  aataagaaa  1920
acattccta  aagatgata  ttgtgaaaa  ctcctttgg  ttatttgct  ttccagatt  1980
tagtctcct  tctccccat  cgggaaaga  kgtggaaga  ataggctaa  tttctccag  2040
ctcacaatg  tcttcactt  gtctgactt  taccaattc  agcacccac  gaaaaacaa  2100
ttgagtaga  agtgtagag  gcagaaatg  ggcttttgc  ccactttgc  tctccaaaa  2160
tacaacggt  ggccgatcn  aattgagga  aatgnttag  tataagtct  cgagttgga  2220
aaggaagaa  gccagagct  tctagtttc  ttcattctt  cagtaaata  ttattgagt  2280
aaaaaaaaa  aaaaaaaaa  aaaaaaa  2307



<210> 6225
<211> 401
<212> PRT
<213> Homo sapiens
<308> O75718
<400> 6225

Met Glu Pro Gly Arg Arg Gly Ala Ala Ala Leu Leu Ala Leu Leu Cys 
  1               5                  10                  15
Val Ala Cys Ala Leu Arg Ala Gly Arg Ala Gln Tyr Glu Arg Tyr Ser 
             20                  25                  30
Phe Arg Ser Phe Pro Arg Asp Glu Leu Met Pro Leu Glu Ser Ala Tyr 
         35                  40                  45
Arg His Ala Leu Asp Lys Tyr Ser Gly Glu His Trp Ala Glu Ser Val 
     50                  55                  60
Gly Tyr Leu Glu Ile Ser Leu Arg Leu His Arg Leu Leu Arg Asp Ser 
 65                  70                  75                  80
Glu Ala Phe Cys His Arg Asn Cys Ser Ala Ala Pro Gln Pro Glu Pro 
                 85                  90                  95
Ala Ala Gly Leu Ala Ser Tyr Pro Glu Leu Arg Leu Phe Gly Gly Leu 
             100                105                110
Leu Arg Arg Ala His Cys Leu Lys Arg Cys Lys Gln Gly Leu Pro Ala 
         115                120                125
Phe Arg Gln Ser Gln Pro Ser Arg Glu Val Leu Ala Asp Phe Gln Arg 
     130                135                140
Arg Glu Pro Tyr Lys Phe Leu Gln Phe Ala Tyr Phe Lys Ala Asn Asn 
 145                150                155                160
Leu Pro Lys Ala Ile Ala Ala Ala His Thr Phe Leu Leu Lys His Pro 
                 165                170                175
Asp Asp Glu Met Met Lys Arg Asn Met Ala Tyr Tyr Lys Ser Leu Pro 
             180                185                190
Gly Ala Glu Asp Tyr Ile Lys Asp Leu Glu Thr Lys Ser Tyr Glu Ser 
         195                200                205
Leu Phe Ile Arg Ala Val Arg Ala Tyr Asn Gly Glu Asn Trp Arg Thr 
     210                215                220
Ser Ile Thr Asp Met Glu Leu Ala Leu Pro Asp Phe Phe Lys Ala Phe 
 225                230                235                240
Tyr Glu Cys Leu Ala Ala Cys Glu Gly Ser Arg Glu Ile Lys Asp Phe 
                 245                250                255
Lys Asp Phe Tyr Leu Ser Ile Ala Asp His Tyr Val Glu Val Leu Glu 
             260                265                270
Cys Lys Ile Gln Cys Glu Glu Asn Leu Thr Pro Val Ile Gly Gly Tyr 
         275                280                285
Pro Val Glu Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala 
     290                295                300
Tyr Tyr Lys Leu Asn Asp Leu Lys Asn Ala Ala Pro Cys Ala Val Ser 
 305                310                315                320
Tyr Leu Leu Phe Asp Gln Asn Asp Lys Val Met Gln Gln Asn Leu Val 
                 325                330                335
Tyr Tyr Gln Tyr His Arg Asp Thr Trp Gly Leu Ser Asp Glu His Phe 
             340                345                350
Gln Pro Arg Pro Glu Ala Val Gln Phe Phe Asn Val Thr Thr Leu Gln 
         355                360                365
Lys Glu Leu Tyr Asp Phe Ala Lys Glu Asn Ile Met Asp Asp Asp Glu 
     370                375                380
Gly Glu Val Val Glu Tyr Val Asp Asp Leu Leu Glu Leu Glu Glu Thr 
 385                390                395                400
Ser 
                 405



<210> 6226
<211> 630
<212> DNA
<213> Rattus norvegicus
<308> AA894207
<400> 6226

aatggagtg  gctggatgt  tctacagtt  tgttcagat  actacagaa  ctggaaaag  60
tgttgctgc  gttgatgca  aacacactg  tattattgg  ctttttata  aaatataaa  120
atatatata  agataaata  tttgaattt  ttgaaactt  acctgtgct  tcaactttg  180
aaaaaagta  ccccgttta  tgtgttgag  tggcactgt  aagaaatta  cagccatat  240
ggtctagaa  tgttgaact  gagtttttt  catttgtac  ggggtaaca  actgtatta  300
atatgtaag  tcttatcta  gtgggtttg  ttacaaaaa  taataaagt  ttctctaaa  360
taaaaaaaa  gatgtatgt  tactaaggg  tgagtcaca  cactagaaa  agttttttt  420
taaaataaa  aacttaatc  tggggttca  attgagatc  aatatccta  aacaggtcg  480
tttccaata  ttcctcaag  cgtcaagta  cgactagct  ctttccagc  atccagctc  540
gctctgatg  catgtacct  gagaccaca  cacagattc  cagaagcag  gtgagggtt  600
agcctanag  agtgcccct  tacctctgac  630



<210> 6227
<211> 618
<212> PRT
<213> Rattus norvegicus
<308> AAF17574
<400> 6227

Met Ser Gln Leu Ser Ser Thr Leu Lys Arg Tyr Thr Glu Ser Ser Arg 
  1               5                  10                  15
Tyr Thr Asp Ala Pro Tyr Ala Lys Ser Gly Tyr Gly Thr Tyr Thr Pro 
             20                  25                  30
Ser Ser Tyr Gly Ala Asn Leu Ala Ala Ser Phe Leu Glu Lys Glu Lys 
         35                  40                  45
Leu Gly Phe Lys Pro Val Ser Pro Thr Ser Phe Leu Pro Arg Pro Arg 
     50                  55                  60
Thr Tyr Gly Pro Ser Ser Ile Leu Asp Cys Asp Arg Gly Arg Pro Leu 
 65                  70                  75                  80
Leu Arg Ser Asp Ile Thr Gly Gly Ser Lys Arg Ser Glu Ser Gln Thr 
                 85                  90                  95
Arg Gly Asn Glu Arg Pro Ser Gly Ser Gly Leu Asn Gly Gly Ser Gly 
             100                105                110
Phe Pro Tyr Gly Val Thr Ser Asn Ser Leu Ser Tyr Leu Pro Met Asn 
         115                120                125
Ala Arg Asp Gln Gly Val Thr Leu Gly Gln Lys Lys Ser Asn Ser Gln 
     130                135                140
Ser Asp Leu Ala Arg Asp Phe Ser Ser Leu Arg Thr Ser Asp Ser Tyr 
 145                150                155                160
Arg Thr Ser Asp Gly Tyr Arg Ala Ser Asp Gly Ser Arg Ile Asp Pro 
                 165                170                175
Gly Asn Leu Gly Arg Ser Pro Met Leu Ala Arg Thr Arg Lys Glu Leu 
             180                185                190
Cys Ala Leu Gln Gly Leu Tyr Gln Ala Ala Ser Arg Ser Glu Tyr Leu 
         195                200                205
Thr Asp Tyr Leu Glu Asn Tyr Gly Arg Lys Gly Ser Ala Pro Gln Val 
     210                215                220
Leu Thr Gln Ala Pro Pro Ser Arg Val Pro Glu Val Leu Ser Pro Thr 
 225                230                235                240
Tyr Arg Pro Ser Gly Arg Tyr Thr Leu Trp Glu Lys Asn Lys Gly Gln 
                 245                250                255
Ala Ser Gly Ala Ser Arg Ser Thr Ser Pro Gly Arg Asp Thr Met Asn 
             260                265                270
Ser Lys Ser Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly Asn Thr 
         275                280                285
Cys Phe Met Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg Glu Leu 
     290                295                300
Arg Asp Tyr Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu Gly His Thr 
 305                310                315                320
Ser Ser Ala His Thr Ala Leu Met Glu Glu Phe Ala Lys Leu Ile Gln 
                 325                330                335
Thr Ile Trp Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser Glu Phe 
             340                345                350
Lys Thr Gln Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr Asn Gln 
         355                360                365
Gln Asp Ala Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu His Asn 
     370                375                380
Glu Val Asn Arg Val Ala Ala Arg Pro Lys Pro Ser Pro Glu Ser Leu 
 385                390                395                400
Asp His Leu Pro Asp Glu Glu Lys Gly Arg Gln Met Trp Arg Lys Tyr 
                 405                410                415
Leu Glu Arg Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly Gln Leu 
             420                425                430
Lys Ser Ser Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr Val Phe 
         435                440                445
Asp Pro Phe Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly Tyr Pro 
     450                455                460
Glu Val Thr Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu Asp Val 
 465                470                475                480
Leu Asp Gly Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Ala Arg Lys 
                 485                490                495
Arg Cys Ile Lys Lys Phe Ser Val Gln Arg Phe Pro Lys Ile Leu Val 
             500                505                510
Leu His Leu Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser Lys Leu 
         515                520                525
Thr Thr Phe Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg Glu Phe 
     530                535                540
Ala Ser Glu Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala Val Ser 
 545                550                555                560
Asn His Ser Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr Cys Arg 
                 565                570                575
Ser Pro Val Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser Val Thr 
             580                585                590
Pro Met Ser Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu Leu Phe 
         595                600                605
Tyr Glu Leu Ala Ser Pro Pro Ser Arg Met 
     610                615



<210> 6228
<211> 2307
<212> DNA
<213> Homo sapiens
<308> AJ006470
<400> 6228

ggcacgagg  gatggagcc  gggcgccgg  gggccgcgg  gctgctagc  ctgctgtgc  60
tggcctgcg  gctgcgcgc  gggcgcgcc  aatacgaac  ctacagctt  cgcagcttc  120
cacgggacg  gctgatgcc  ctcgagtcg  cctaccggc  cgcgctgga  aagtacagc  180
gcgagcact  ggccgagag  gtgggctac  tggagatca  cctgcggct  caccgcttg  240
tgcgcgaca  cgaggcctt  tgccaccgc  actgcagcg  cgcgccgca  cccgagccc  300
ccgccggcc  cgccagcta  cccgagctg  gcctcttcg  gggcctgct  cgccgcgcg  360
actgcctca  gcgctgcaa  cagggcctg  cagccttcc  ccagtccca  cccagccgc  420
aggtgctgg  ggacttcca  cgccgcgag  cctacaagt  cctgcagtt  gcttacttc  480
aggcaaata  tctccccaa  gccatcgcc  ctgctcaca  ctttctact  aagcatcct  540
atgacgaaa  gatgaagag  aacatggca  attataaga  cctgcctgg  gccgaggac  600
acattaaag  cctggaaac  aagtcatat  aaagcctgt  catccgagc  gtgcgggca  660
acaacggtg  gaactggag  acatccatc  cagacatgg  gctggccct  cccgacttc  720
tcaaagcct  ttacgagtg  ctcgcagcc  gcgagggtt  cagggagat  aaggacttc  780
aggatttct  cctttccat  gcagatcat  atgtagaag  tctggaatg  aaaatacag  840
gtgaagaga  cctcacccc  gttatagga  gctatccgg  tgagaaatt  gtggctacc  900
tgtatcatt  cttgcagtt  gcctattat  agttgaacg  cctgaagaa  gcagccccc  960
gtgcagtca  ctatctgct  tttgatcag  atgacaagg  catgcagca  aacctggtg  1020
attaccagt  ccacaggga  acttggggc  tctcggatg  gcacttcca  cccagacct  1080
aagcagttc  gttctttaa  gtgaccaca  tccagaagg  gctgtatga  tttgctaag  1140
aaaatataa  ggatgatga  gagggagaa  ttgtggaat  tgtggatga  ctcttggaa  1200
tggaggaga  cagctagcc  acagcaacc  aagagactt  ctcttggcg  tcaggaaac  1260
cagattctt  gtccttttc  caacagccc  ggctgttga  acctcagag  cttctcttt  1320
ctctccaaa  tgaaaggga  gcccccgtc  ctctaactg  atgtcatca  gggtgagcc  1380
gcctttcct  tcttcacac  tgccacctc  tgttcacac  tatctttct  acctttttt  1440
tgagatgga  tctcgctct  ttgcccagg  tggagtgca  tggcacgtt  tcagctcac  1500
gcaacctcc  cctcttggg  tcaagcaat  ctgctgcat  agcctcccg  gtacctggg  1560
ttacaggca  gtgccacca  gcccggcta  ttttgtatt  ttaagtaag  gacggggtt  1620
tgccatgtt  gccaggctg  tctcgaact  ttgacttca  atgatccat  tgccttggg  1680
ctcccacag  gctgggatt  caggcgtga  ccaccatgc  cggcctctt  ctcaccttt  1740
cacctgtct  cttatcctc  catctgttt  cacaccttc  tccctgtct  cctcatgtt  1800
acacttgtc  tccccatgt  catagctgc  tttcttacc  ttttggttt  aagggcagt  1860
ttctctggc  tgttttttt  tttttccca  aaaatcagt  ttatttttt  aataagaaa  1920
acattccta  aagatgata  ttgtgaaaa  ctcctttgg  ttatttgct  ttccagatt  1980
tagtctcct  tctccccat  cgggaaaga  kgtggaaga  ataggctaa  tttctccag  2040
ctcacaatg  tcttcactt  gtctgactt  taccaattc  agcacccac  gaaaaacaa  2100
ttgagtaga  agtgtagag  gcagaaatg  ggcttttgc  ccactttgc  tctccaaaa  2160
tacaacggt  ggccgatcn  aattgagga  aatgnttag  tataagtct  cgagttgga  2220
aaggaagaa  gccagagct  tctagtttc  ttcattctt  cagtaaata  ttattgagt  2280
aaaaaaaaa  aaaaaaaaa  aaaaaaa  2307



<210> 6229
<211> 401
<212> PRT
<213> Homo sapiens
<308> O75718
<400> 6229

Met Glu Pro Gly Arg Arg Gly Ala Ala Ala Leu Leu Ala Leu Leu Cys 
  1               5                  10                  15
Val Ala Cys Ala Leu Arg Ala Gly Arg Ala Gln Tyr Glu Arg Tyr Ser 
             20                  25                  30
Phe Arg Ser Phe Pro Arg Asp Glu Leu Met Pro Leu Glu Ser Ala Tyr 
         35                  40                  45
Arg His Ala Leu Asp Lys Tyr Ser Gly Glu His Trp Ala Glu Ser Val 
     50                  55                  60
Gly Tyr Leu Glu Ile Ser Leu Arg Leu His Arg Leu Leu Arg Asp Ser 
 65                  70                  75                  80
Glu Ala Phe Cys His Arg Asn Cys Ser Ala Ala Pro Gln Pro Glu Pro 
                 85                  90                  95
Ala Ala Gly Leu Ala Ser Tyr Pro Glu Leu Arg Leu Phe Gly Gly Leu 
             100                105                110
Leu Arg Arg Ala His Cys Leu Lys Arg Cys Lys Gln Gly Leu Pro Ala 
         115                120                125
Phe Arg Gln Ser Gln Pro Ser Arg Glu Val Leu Ala Asp Phe Gln Arg 
     130                135                140
Arg Glu Pro Tyr Lys Phe Leu Gln Phe Ala Tyr Phe Lys Ala Asn Asn 
 145                150                155                160
Leu Pro Lys Ala Ile Ala Ala Ala His Thr Phe Leu Leu Lys His Pro 
                 165                170                175
Asp Asp Glu Met Met Lys Arg Asn Met Ala Tyr Tyr Lys Ser Leu Pro 
             180                185                190
Gly Ala Glu Asp Tyr Ile Lys Asp Leu Glu Thr Lys Ser Tyr Glu Ser 
         195                200                205
Leu Phe Ile Arg Ala Val Arg Ala Tyr Asn Gly Glu Asn Trp Arg Thr 
     210                215                220
Ser Ile Thr Asp Met Glu Leu Ala Leu Pro Asp Phe Phe Lys Ala Phe 
 225                230                235                240
Tyr Glu Cys Leu Ala Ala Cys Glu Gly Ser Arg Glu Ile Lys Asp Phe 
                 245                250                255
Lys Asp Phe Tyr Leu Ser Ile Ala Asp His Tyr Val Glu Val Leu Glu 
             260                265                270
Cys Lys Ile Gln Cys Glu Glu Asn Leu Thr Pro Val Ile Gly Gly Tyr 
         275                280                285
Pro Val Glu Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala 
     290                295                300
Tyr Tyr Lys Leu Asn Asp Leu Lys Asn Ala Ala Pro Cys Ala Val Ser 
 305                310                315                320
Tyr Leu Leu Phe Asp Gln Asn Asp Lys Val Met Gln Gln Asn Leu Val 
                 325                330                335
Tyr Tyr Gln Tyr His Arg Asp Thr Trp Gly Leu Ser Asp Glu His Phe 
             340                345                350
Gln Pro Arg Pro Glu Ala Val Gln Phe Phe Asn Val Thr Thr Leu Gln 
         355                360                365
Lys Glu Leu Tyr Asp Phe Ala Lys Glu Asn Ile Met Asp Asp Asp Glu 
     370                375                380
Gly Glu Val Val Glu Tyr Val Asp Asp Leu Leu Glu Leu Glu Glu Thr 
 385                390                395                400
Ser 
                 405



<210> 6230
<211> 630
<212> DNA
<213> Rattus norvegicus
<308> AA894207
<400> 6230

aatggagtg  gctggatgt  tctacagtt  tgttcagat  actacagaa  ctggaaaag  60
tgttgctgc  gttgatgca  aacacactg  tattattgg  ctttttata  aaatataaa  120
atatatata  agataaata  tttgaattt  ttgaaactt  acctgtgct  tcaactttg  180
aaaaaagta  ccccgttta  tgtgttgag  tggcactgt  aagaaatta  cagccatat  240
ggtctagaa  tgttgaact  gagtttttt  catttgtac  ggggtaaca  actgtatta  300
atatgtaag  tcttatcta  gtgggtttg  ttacaaaaa  taataaagt  ttctctaaa  360
taaaaaaaa  gatgtatgt  tactaaggg  tgagtcaca  cactagaaa  agttttttt  420
taaaataaa  aacttaatc  tggggttca  attgagatc  aatatccta  aacaggtcg  480
tttccaata  ttcctcaag  cgtcaagta  cgactagct  ctttccagc  atccagctc  540
gctctgatg  catgtacct  gagaccaca  cacagattc  cagaagcag  gtgagggtt  600
agcctanag  agtgcccct  tacctctgac  630



<210> 6231
<211> 618
<212> PRT
<213> Rattus norvegicus
<308> AAF17574
<400> 6231

Met Ser Gln Leu Ser Ser Thr Leu Lys Arg Tyr Thr Glu Ser Ser Arg 
  1               5                  10                  15
Tyr Thr Asp Ala Pro Tyr Ala Lys Ser Gly Tyr Gly Thr Tyr Thr Pro 
             20                  25                  30
Ser Ser Tyr Gly Ala Asn Leu Ala Ala Ser Phe Leu Glu Lys Glu Lys 
         35                  40                  45
Leu Gly Phe Lys Pro Val Ser Pro Thr Ser Phe Leu Pro Arg Pro Arg 
     50                  55                  60
Thr Tyr Gly Pro Ser Ser Ile Leu Asp Cys Asp Arg Gly Arg Pro Leu 
 65                  70                  75                  80
Leu Arg Ser Asp Ile Thr Gly Gly Ser Lys Arg Ser Glu Ser Gln Thr 
                 85                  90                  95
Arg Gly Asn Glu Arg Pro Ser Gly Ser Gly Leu Asn Gly Gly Ser Gly 
             100                105                110
Phe Pro Tyr Gly Val Thr Ser Asn Ser Leu Ser Tyr Leu Pro Met Asn 
         115                120                125
Ala Arg Asp Gln Gly Val Thr Leu Gly Gln Lys Lys Ser Asn Ser Gln 
     130                135                140
Ser Asp Leu Ala Arg Asp Phe Ser Ser Leu Arg Thr Ser Asp Ser Tyr 
 145                150                155                160
Arg Thr Ser Asp Gly Tyr Arg Ala Ser Asp Gly Ser Arg Ile Asp Pro 
                 165                170                175
Gly Asn Leu Gly Arg Ser Pro Met Leu Ala Arg Thr Arg Lys Glu Leu 
             180                185                190
Cys Ala Leu Gln Gly Leu Tyr Gln Ala Ala Ser Arg Ser Glu Tyr Leu 
         195                200                205
Thr Asp Tyr Leu Glu Asn Tyr Gly Arg Lys Gly Ser Ala Pro Gln Val 
     210                215                220
Leu Thr Gln Ala Pro Pro Ser Arg Val Pro Glu Val Leu Ser Pro Thr 
 225                230                235                240
Tyr Arg Pro Ser Gly Arg Tyr Thr Leu Trp Glu Lys Asn Lys Gly Gln 
                 245                250                255
Ala Ser Gly Ala Ser Arg Ser Thr Ser Pro Gly Arg Asp Thr Met Asn 
             260                265                270
Ser Lys Ser Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly Asn Thr 
         275                280                285
Cys Phe Met Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg Glu Leu 
     290                295                300
Arg Asp Tyr Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu Gly His Thr 
 305                310                315                320
Ser Ser Ala His Thr Ala Leu Met Glu Glu Phe Ala Lys Leu Ile Gln 
                 325                330                335
Thr Ile Trp Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser Glu Phe 
             340                345                350
Lys Thr Gln Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr Asn Gln 
         355                360                365
Gln Asp Ala Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu His Asn 
     370                375                380
Glu Val Asn Arg Val Ala Ala Arg Pro Lys Pro Ser Pro Glu Ser Leu 
 385                390                395                400
Asp His Leu Pro Asp Glu Glu Lys Gly Arg Gln Met Trp Arg Lys Tyr 
                 405                410                415
Leu Glu Arg Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly Gln Leu 
             420                425                430
Lys Ser Ser Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr Val Phe 
         435                440                445
Asp Pro Phe Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly Tyr Pro 
     450                455                460
Glu Val Thr Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu Asp Val 
 465                470                475                480
Leu Asp Gly Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Ala Arg Lys 
                 485                490                495
Arg Cys Ile Lys Lys Phe Ser Val Gln Arg Phe Pro Lys Ile Leu Val 
             500                505                510
Leu His Leu Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser Lys Leu 
         515                520                525
Thr Thr Phe Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg Glu Phe 
     530                535                540
Ala Ser Glu Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala Val Ser 
 545                550                555                560
Asn His Ser Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr Cys Arg 
                 565                570                575
Ser Pro Val Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser Val Thr 
             580                585                590
Pro Met Ser Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu Leu Phe 
         595                600                605
Tyr Glu Leu Ala Ser Pro Pro Ser Arg Met 
     610                615



<210> 6232
<211> 2307
<212> DNA
<213> Homo sapiens
<308> AJ006470
<400> 6232

ggcacgagg  gatggagcc  gggcgccgg  gggccgcgg  gctgctagc  ctgctgtgc  60
tggcctgcg  gctgcgcgc  gggcgcgcc  aatacgaac  ctacagctt  cgcagcttc  120
cacgggacg  gctgatgcc  ctcgagtcg  cctaccggc  cgcgctgga  aagtacagc  180
gcgagcact  ggccgagag  gtgggctac  tggagatca  cctgcggct  caccgcttg  240
tgcgcgaca  cgaggcctt  tgccaccgc  actgcagcg  cgcgccgca  cccgagccc  300
ccgccggcc  cgccagcta  cccgagctg  gcctcttcg  gggcctgct  cgccgcgcg  360
actgcctca  gcgctgcaa  cagggcctg  cagccttcc  ccagtccca  cccagccgc  420
aggtgctgg  ggacttcca  cgccgcgag  cctacaagt  cctgcagtt  gcttacttc  480
aggcaaata  tctccccaa  gccatcgcc  ctgctcaca  ctttctact  aagcatcct  540
atgacgaaa  gatgaagag  aacatggca  attataaga  cctgcctgg  gccgaggac  600
acattaaag  cctggaaac  aagtcatat  aaagcctgt  catccgagc  gtgcgggca  660
acaacggtg  gaactggag  acatccatc  cagacatgg  gctggccct  cccgacttc  720
tcaaagcct  ttacgagtg  ctcgcagcc  gcgagggtt  cagggagat  aaggacttc  780
aggatttct  cctttccat  gcagatcat  atgtagaag  tctggaatg  aaaatacag  840
gtgaagaga  cctcacccc  gttatagga  gctatccgg  tgagaaatt  gtggctacc  900
tgtatcatt  cttgcagtt  gcctattat  agttgaacg  cctgaagaa  gcagccccc  960
gtgcagtca  ctatctgct  tttgatcag  atgacaagg  catgcagca  aacctggtg  1020
attaccagt  ccacaggga  acttggggc  tctcggatg  gcacttcca  cccagacct  1080
aagcagttc  gttctttaa  gtgaccaca  tccagaagg  gctgtatga  tttgctaag  1140
aaaatataa  ggatgatga  gagggagaa  ttgtggaat  tgtggatga  ctcttggaa  1200
tggaggaga  cagctagcc  acagcaacc  aagagactt  ctcttggcg  tcaggaaac  1260
cagattctt  gtccttttc  caacagccc  ggctgttga  acctcagag  cttctcttt  1320
ctctccaaa  tgaaaggga  gcccccgtc  ctctaactg  atgtcatca  gggtgagcc  1380
gcctttcct  tcttcacac  tgccacctc  tgttcacac  tatctttct  acctttttt  1440
tgagatgga  tctcgctct  ttgcccagg  tggagtgca  tggcacgtt  tcagctcac  1500
gcaacctcc  cctcttggg  tcaagcaat  ctgctgcat  agcctcccg  gtacctggg  1560
ttacaggca  gtgccacca  gcccggcta  ttttgtatt  ttaagtaag  gacggggtt  1620
tgccatgtt  gccaggctg  tctcgaact  ttgacttca  atgatccat  tgccttggg  1680
ctcccacag  gctgggatt  caggcgtga  ccaccatgc  cggcctctt  ctcaccttt  1740
cacctgtct  cttatcctc  catctgttt  cacaccttc  tccctgtct  cctcatgtt  1800
acacttgtc  tccccatgt  catagctgc  tttcttacc  ttttggttt  aagggcagt  1860
ttctctggc  tgttttttt  tttttccca  aaaatcagt  ttatttttt  aataagaaa  1920
acattccta  aagatgata  ttgtgaaaa  ctcctttgg  ttatttgct  ttccagatt  1980
tagtctcct  tctccccat  cgggaaaga  kgtggaaga  ataggctaa  tttctccag  2040
ctcacaatg  tcttcactt  gtctgactt  taccaattc  agcacccac  gaaaaacaa  2100
ttgagtaga  agtgtagag  gcagaaatg  ggcttttgc  ccactttgc  tctccaaaa  2160
tacaacggt  ggccgatcn  aattgagga  aatgnttag  tataagtct  cgagttgga  2220
aaggaagaa  gccagagct  tctagtttc  ttcattctt  cagtaaata  ttattgagt  2280
aaaaaaaaa  aaaaaaaaa  aaaaaaa  2307



<210> 6233
<211> 401
<212> PRT
<213> Homo sapiens
<308> O75718
<400> 6233

Met Glu Pro Gly Arg Arg Gly Ala Ala Ala Leu Leu Ala Leu Leu Cys 
  1               5                  10                  15
Val Ala Cys Ala Leu Arg Ala Gly Arg Ala Gln Tyr Glu Arg Tyr Ser 
             20                  25                  30
Phe Arg Ser Phe Pro Arg Asp Glu Leu Met Pro Leu Glu Ser Ala Tyr 
         35                  40                  45
Arg His Ala Leu Asp Lys Tyr Ser Gly Glu His Trp Ala Glu Ser Val 
     50                  55                  60
Gly Tyr Leu Glu Ile Ser Leu Arg Leu His Arg Leu Leu Arg Asp Ser 
 65                  70                  75                  80
Glu Ala Phe Cys His Arg Asn Cys Ser Ala Ala Pro Gln Pro Glu Pro 
                 85                  90                  95
Ala Ala Gly Leu Ala Ser Tyr Pro Glu Leu Arg Leu Phe Gly Gly Leu 
             100                105                110
Leu Arg Arg Ala His Cys Leu Lys Arg Cys Lys Gln Gly Leu Pro Ala 
         115                120                125
Phe Arg Gln Ser Gln Pro Ser Arg Glu Val Leu Ala Asp Phe Gln Arg 
     130                135                140
Arg Glu Pro Tyr Lys Phe Leu Gln Phe Ala Tyr Phe Lys Ala Asn Asn 
 145                150                155                160
Leu Pro Lys Ala Ile Ala Ala Ala His Thr Phe Leu Leu Lys His Pro 
                 165                170                175
Asp Asp Glu Met Met Lys Arg Asn Met Ala Tyr Tyr Lys Ser Leu Pro 
             180                185                190
Gly Ala Glu Asp Tyr Ile Lys Asp Leu Glu Thr Lys Ser Tyr Glu Ser 
         195                200                205
Leu Phe Ile Arg Ala Val Arg Ala Tyr Asn Gly Glu Asn Trp Arg Thr 
     210                215                220
Ser Ile Thr Asp Met Glu Leu Ala Leu Pro Asp Phe Phe Lys Ala Phe 
 225                230                235                240
Tyr Glu Cys Leu Ala Ala Cys Glu Gly Ser Arg Glu Ile Lys Asp Phe 
                 245                250                255
Lys Asp Phe Tyr Leu Ser Ile Ala Asp His Tyr Val Glu Val Leu Glu 
             260                265                270
Cys Lys Ile Gln Cys Glu Glu Asn Leu Thr Pro Val Ile Gly Gly Tyr 
         275                280                285
Pro Val Glu Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala 
     290                295                300
Tyr Tyr Lys Leu Asn Asp Leu Lys Asn Ala Ala Pro Cys Ala Val Ser 
 305                310                315                320
Tyr Leu Leu Phe Asp Gln Asn Asp Lys Val Met Gln Gln Asn Leu Val 
                 325                330                335
Tyr Tyr Gln Tyr His Arg Asp Thr Trp Gly Leu Ser Asp Glu His Phe 
             340                345                350
Gln Pro Arg Pro Glu Ala Val Gln Phe Phe Asn Val Thr Thr Leu Gln 
         355                360                365
Lys Glu Leu Tyr Asp Phe Ala Lys Glu Asn Ile Met Asp Asp Asp Glu 
     370                375                380
Gly Glu Val Val Glu Tyr Val Asp Asp Leu Leu Glu Leu Glu Glu Thr 
 385                390                395                400
Ser 
                 405



<210> 6234
<211> 461
<212> DNA
<213> Rattus norvegicus
<308> AA894234
<400> 6234

ggctggtga  agtatggtg  ctcacacga  atggttcca  atctgtcac  accctccgt  60
aggcccctc  ccggtctcc  gataccaag  ctccagcag  caaaggccg  tcttgcatc  120
gtgaccatg  ctgctacct  ccttcatgg  aggacctca  tatctctcc  ccaacaggc  180
tcacatttc  agggttcct  tcagacttg  gccggaccc  atctggagg  ctgagcagc  240
cgaggtgat  gggcacaag  gtcagcaga  tgtccgatg  gcccaagtc  agacattgg  300
cttacgggc  gagctgagg  ggatctcct  gagctccgt  cgcatgcac  ggtactccc  360
gatgacggc  atgagtgca  tgcacacag  ttggaccag  caccaggtc  gcgccgagg  420
gaaacggga  ctgtacagc  agcagccca  gaggtgaca  a  461



<210> 6235
<211> 679
<212> DNA
<213> Homo sapiens
<308> BG715448
<400> 6235

agcggaggc  cggctcgtg  ccctgcagg  catggcggg  cagttccgc  gctacgtgt  60
ggacccgct  ctgatcctg  cgcagatcg  cctcatgca  accgtgtat  acggctcgc  120
gggcctgtg  ctggcgctg  tggacgggc  agtgcgaag  agcccctcg  tggaccaga  180
gttcgacgc  gagatcctg  gcttttcca  ccctccagg  cggctctcc  tgatgtcct  240
catcctcaa  gccctcacc  ggcacttct  cttgctgct  ccacatgaa  aaggacgtg  300
ttgcttccc  ttccaccat  attgagctg  catggaccc  aatcctcgg  ccgccctgg  360
gcgccagca  ctccgcctt  gggagcggc  aaaattctt  gaggacatt  tacagccag  420
gacagagtt  gtctttcct  tgtcccatc  gcatctcga  tcgcagaga  cccccatag  480
tagtatctc  tccatggaa  tgaactgtg  acacactgg  gcacgtaga  cttattgac  540
ttggggacc  ggatgcaga  agatgtgat  ttgccttgc  aagatcctc  accaagccc  600
agtcgtctg  ggtggacaa  cattctgga  gagctgacg  ctgccggtg  ctacatcag  660
cacggacca  atctaggag  679



<210> 6236
<211> 672
<212> DNA
<213> Rattus norvegicus
<308> AA894258
<400> 6236

ataatcttt  ttgagcttc  gttacagaa  gggtgtgac  tttgccctt  tggtgagtt  60
gtctggatg  gtgttctca  cccgaatga  aagtaaaat  ttaacagag  acagaatag  120
aaggacctt  gggatcact  agcccagcc  attattttc  tggaggaaa  gaaaccaaa  180
aaaggagaa  gatctagcg  aggtctcac  gcaagggag  ctggtccct  tcaatctcc  240
ttcctaacc  cagtactct  tgctaagct  tttccccaa  cctttgggt  tgctggctt  300
ctttatgtg  tcccactgg  taaacaacc  aactatcag  tacctaaca  gacggtagg  360
acttttact  cagctttaa  atcagcata  cgaaatgat  cctgagcct  tagctactt  420
attattgag  atgcagtcc  cagtaaatc  tggctatct  cggtagtca  cttcaaatg  480
ttgcacaga  accaaaagc  ctaatgaca  ttgtacgaa  gcatccatg  gattccagg  540
cgcttctca  ggaatacag  ggcaccatg  tggtgacca  aagaggctt  agtctctca  600
agtgcggtc  tgagtttgt  ccggtatgt  acactgtac  cccctccta  gttcctctg  660
atctggtcg  gg  672



<210> 6237
<211> 147
<212> PRT
<213> Rattus norvegicus
<308> P47986
<400> 6237

Met Ala Leu Lys Arg Ile Asn Lys Glu Leu Ser Asp Leu Ala Arg Asp 
  1               5                  10                  15
Pro Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Met Phe His 
             20                  25                  30
Trp Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly 
         35                  40                  45
Val Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
     50                  55                  60
Pro Lys Val Ala Phe Thr Thr Arg Ile Tyr His Pro Asn Ile Asn Ser 
 65                  70                  75                  80
Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                 85                  90                  95
Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
             100                105                110
Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Arg Ile Tyr Lys 
         115                120                125
Thr Asp Arg Asp Lys Tyr Asn Arg Ile Ser Arg Glu Trp Thr Gln Lys 
     130                135                140
Tyr Ala Met 
 145



<210> 6238
<211> 724
<212> DNA
<213> Homo sapiens
<308> U39318
<400> 6238

gagcataca  cgagagagt  aggagccag  cgacaagca  acactatgg  gctgaaacg  60
attaataag  aacttagtg  tttggcccg  gaccctcca  cacaatgtt  tgcaggtcc  120
gttggggat  atatgtttc  ttggcaagc  acaattatg  gacctaatg  cagcccata  180
caaggcggt  tattctttt  gacaattca  tttcctaca  actacccct  caaaccacc  240
aaggttgca  ttacaacaa  aatttatca  ccaaatatt  acagtaatg  cagcatttg  300
ctcgatatt  taagatcac  gtggtcgcc  gctttaaca  tttctaaag  tcttttatc  360
atttgttca  tgctatgtg  tccaaaccc  gatgacccc  tagtgccag  gattgcacg  420
atctataaa  cagacagag  taagtacaa  agaatatct  gggaatgga  tcagaagta  480
gccatgtga  gctacctta  agtcagaat  acctgcatt  tagctggaa  aaactttaa  540
ttactgttc  ttttttgat  ttcttatcc  gctgctccc  tgatcagac  tcatctttt  600
taattttat  ttttgttta  ctccctcca  tcattcaca  gctcatctg  gaagactta  660
gttcttcca  ctttgacaa  aactgcttt  agaaactgt  aagtagtta  aagagaaca  720
ttgg  724



<210> 6239
<211> 147
<212> PRT
<213> Homo sapiens
<308> P47986
<400> 6239

Met Ala Leu Lys Arg Ile Asn Lys Glu Leu Ser Asp Leu Ala Arg Asp 
  1               5                  10                  15
Pro Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Met Phe His 
             20                  25                  30
Trp Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly 
         35                  40                  45
Val Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
     50                  55                  60
Pro Lys Val Ala Phe Thr Thr Arg Ile Tyr His Pro Asn Ile Asn Ser 
 65                  70                  75                  80
Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                 85                  90                  95
Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
             100                105                110
Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Arg Ile Tyr Lys 
         115                120                125
Thr Asp Arg Asp Lys Tyr Asn Arg Ile Ser Arg Glu Trp Thr Gln Lys 
     130                135                140
Tyr Ala Met 
 145



<210> 6240
<211> 573
<212> DNA
<213> Rattus norvegicus
<308> AA894273
<400> 6240

ggcgaggtt  attacggcg  cctattaca  agatctccg  gccgacacg  atcccgcgc  60
ggagacaga  gtgtcgacc  cgaaactca  aagtcagag  gttatatag  gaaggctag  120
gggttttgg  gtggataca  acaattggc  catttaaac  tagcagtga  aacaaagca  180
aaagagtac  tgttagaag  caggggctt  cagcagggg  caatcagcc  gtcgcagag  240
tctttcctc  acccatgtg  ttctgtcag  gtttgacac  cctgctgtg  tggctccag  300
tccggattg  gcagcaagg  gaccagatt  tccccaacc  gtggagaat  tagtccatg  360
cagctgacc  gtggtccca  cttttggga  actctatca  ccactctat  acagtttaa  420
tcctggatt  ggtgataat  gttagtgcc  ggctggcaa  agtgatgtg  tccaagcag  480
acagcgcta  gccattcat  tcccagcat  agttactgg  gcactgaga  aggtcttaa  540
ctctacata  acagtctat  catatgtat  cac  573



<210> 6241
<211> 284
<212> PRT
<213> Rattus norvegicus
<308> O08557
<400> 6241

Ala Gly Leu Ser His Pro Ser Val Phe Gly Arg Ala Thr His Ala Val 
  1               5                  10                  15
Val Arg Ala Pro Pro Glu Ser Leu Cys Arg His Ala Leu Arg Arg Ser 
             20                  25                  30
Gln Gly Glu Glu Val Asp Phe Ala Arg Ala Glu Arg Gln His Gln Leu 
         35                  40                  45
Tyr Val Gly Val Leu Gly Ser Lys Leu Gly Leu Gln Val Val Gln Leu 
     50                  55                  60
Pro Ala Asp Glu Ser Leu Pro Asp Cys Val Phe Val Glu Asp Val Ala 
 65                  70                  75                  80
Val Val Cys Glu Glu Thr Ala Leu Ile Thr Arg Pro Gly Ala Pro Ser 
                 85                  90                  95
Arg Arg Lys Glu Val Asp Met Met Lys Glu Ala Leu Glu Lys Leu Gln 
             100                105                110
Leu Asn Ile Val Glu Met Lys Asp Glu Asn Ala Thr Leu Asp Gly Gly 
         115                120                125
Asp Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys Arg 
     130                135                140
Thr Asn Gln Arg Gly Ala Glu Ile Leu Ala Asp Thr Phe Lys Asp Tyr 
 145                150                155                160
Ala Val Ser Thr Val Pro Val Ala Asp Ser Leu His Leu Lys Ser Phe 
                 165                170                175
Cys Ser Met Ala Gly Pro Asn Leu Ile Ala Ile Gly Ser Ser Glu Ser 
             180                185                190
Ala Gln Lys Ala Leu Lys Ile Met Gln Gln Met Ser Asp His Arg Tyr 
         195                200                205
Asp Lys Leu Thr Val Pro Asp Asp Met Ala Ala Asn Cys Ile Tyr Leu 
     210                215                220
Asn Ile Pro Ser Lys Gly His Val Leu Leu His Arg Thr Pro Glu Glu 
 225                230                235                240
Tyr Pro Glu Ser Ala Lys Val Tyr Glu Lys Leu Lys Asp His Leu Leu 
                 245                250                255
Ile Pro Val Ser Asn Ser Glu Met Glu Lys Val Asp Gly Leu Leu Thr 
             260                265                270
Cys Cys Ser Val Phe Ile Asn Lys Lys Thr Asp Ser 
         275                280



<210> 6242
<211> 2494
<212> DNA
<213> Homo sapiens
<308> AK001459
<400> 6242

agtagacct  tctgcgagt  cgagccaac  ggcagaccc  actgaatgc  cggattggg  60
aaatgaaac  gaggaagca  gatgaaggg  agagggaag  ctcctgcat  gctgaggat  120
atgctgtgg  catcgagca  gagaacaac  accgctttg  ggagtatga  tggtgtgga  180
agaagcgga  acgggccac  actctcctg  aaggtggct  ccgaggctc  ggcttcatc  240
tgtgcagcg  caaagagaa  ccggacagt  atgctgact  ggatgtgga  ggggatgac  300
ctctggagt  tgggaagcc  caatacaca  aggctgatg  catcccctg  acaggcgag  360
agcctggtg  agccaagga  agagaggca  ttcggggcg  agtcctaaa  ggcggccct  420
ccagcacgc  catcacacc  gagttctct  aatgggcca  tgatgagat  ccatccacc  480
gcaatggtg  aagcagcaa  caggaggcc  tgcagaaga  ctgcaagaa  agcgacatc  540
agaaaatca  cgaagattc  gctgtgacc  cgtttgagg  tctgaaggc  cgggtcaga  600
aacttgaac  gcagctatc  cgtggggac  gttacaaat  cctcatctg  atggactcg  660
actcgatgc  cctaacgtc  atccagtgt  ggcacgtgc  ctgcgagga  tgctggctg  720
ggaccctgg  gaggtggca  gggggtcgg  gaatgggag  ccgctccgg  cactgccca  780
atgtctgtg  ttatgcctg  gcctgcctg  gggaagtgg  gagcatggc  caaaggaga  840
cagagccag  agccaggat  tttacccgc  ggatattta  ccccaggct  gctgcctct  900
ctccccaac  gcaggttta  gaacttctc  ccctccatg  gttcactgc  ttctccctt  960
cccgccccg  tccccgaag  cccactgca  cacacagac  ggtgaggcc  ggggtcagg  1020
ggaggctgg  tgtaggtaa  caggaccag  gccttggcc  ctccccctc  cattactaa  1080
ctccttctg  tcctgcccc  gttcttcgc  caggagcag  cattaaaat  tcgcccgga  1140
acagtaata  aaggctcgg  cgtgggctc  gtgtcctga  caaaggccg  gtgtaatct  1200
gttagggct  cggctgcca  agctggacc  agccttgtt  tcattactg  ggctcctgc  1260
gcggggctg  ccaggcggt  tgatcctgg  gtcccccca  cacaggagc  tgcctgcct  1320
ctcacagaa  ctgcctatg  gtccccagc  tgggctgac  ggaccaagg  ctcagcaca  1380
actggtgca  agagacatg  ctgcaggcc  aggtgctca  atgcgcaca  atggctcat  1440
gtgtagacc  gagccctcc  tgttctccc  gcagggtgc  aagaagctc  gccctcagt  1500
caacacgat  acagcgccc  gagacctgc  gaggatcta  ttgtgagct  tctgcccca  1560
gcaggcctc  cctccagca  ccccacctg  ccccagcct  tgtgacagt  accgtctcc  1620
tttgtacat  cttgcacac  ggttcccca  gtacataca  gcacatact  aaacatgcg  1680
acacacaca  acatttaca  acgcaggac  ctggagcca  agtagaggc  gtggcccag  1740
cactacctg  tggctccca  ctatggttt  ggggccata  ctgttccag  tctgttccc  1800
gggtggggc  gggaggtgg  ggttggggg  gtagtgggg  acggctcct  agatccagc  1860
cccatactg  cagacggac  gacagacat  caaacacca  actgaagca  atgtaatat  1920
gaccgtgta  gtttacaat  ttgtgtata  atgggacaa  tcctcgccc  ctacctgtc  1980
cctccccct  tggttgtat  attttcttc  tttttaaga  cccctggaa  cagcgcctc  2040
ttcagggtt  gctgggagc  cggcccatc  acctcttgg  gtacctgcc  ctctctctc  2100
tgtggtgtc  cttccctct  ccatgtgct  ggtgttcag  ggtgtatat  tcttctccc  2160
gacatgggg  acacgcccc  agggacatg  tcctctcct  agtcttagc  catggggct  2220
tttataagg  gttgggggg  agaggcagg  aatgggaac  gagctgaag  agaggctga  2280
ttagggggc  agaggacag  gctcctggc  acccagcct  tgctgagaa  cattcctgg  2340
attagagct  cctttccca  ggaaaaagt  tcgtctccc  gaccctccc  tgggccctg  2400
ggtgtgatg  tgtgtctgt  tattctata  aaaggtact  gtcctttcc  tttgtaaac  2460
acatttgac  tggattaaa  cagtataaa  agtt  2494



<210> 6243
<211> 246
<212> PRT
<213> Homo sapiens
<308> AK001459
<400> 6243

Met Lys Arg Arg Lys Gln Asp Glu Gly Gln Arg Glu Gly Ser Cys Met 
  1               5                  10                  15
Ala Glu Asp Asp Ala Val Asp Ile Glu His Glu Asn Asn Asn Arg Phe 
             20                  25                  30
Glu Glu Tyr Glu Trp Cys Gly Gln Lys Arg Ile Arg Ala Thr Thr Leu 
         35                  40                  45
Leu Glu Gly Gly Phe Arg Gly Ser Gly Phe Ile Met Cys Ser Gly Lys 
     50                  55                  60
Glu Asn Pro Asp Ser Asp Ala Asp Leu Asp Val Asp Gly Asp Asp Thr 
 65                  70                  75                  80
Leu Glu Tyr Gly Lys Pro Gln Tyr Thr Glu Ala Asp Val Ile Pro Cys 
                 85                  90                  95
Thr Gly Glu Glu Pro Gly Glu Ala Lys Glu Arg Glu Ala Leu Arg Gly 
             100                105                110
Ala Val Leu Asn Gly Gly Pro Pro Ser Thr Arg Ile Thr Pro Glu Phe 
         115                120                125
Ser Lys Trp Ala Ser Asp Glu Met Pro Ser Thr Ser Asn Gly Glu Ser 
     130                135                140
Ser Lys Gln Glu Ala Met Gln Lys Thr Cys Lys Asn Ser Asp Ile Glu 
 145                150                155                160
Lys Ile Thr Glu Asp Ser Ala Val Thr Thr Phe Glu Ala Leu Lys Ala 
                 165                170                175
Arg Val Arg Glu Leu Glu Arg Gln Leu Ser Arg Gly Asp Arg Tyr Lys 
             180                185                190
Cys Leu Ile Cys Met Asp Ser Tyr Ser Met Pro Leu Thr Ser Ile Gln 
         195                200                205
Cys Trp His Val His Cys Glu Glu Cys Trp Leu Arg Thr Leu Val Arg 
     210                215                220
Trp His Gly Gly Arg Gly Met Gly Gly Arg Ser Gly His Cys Pro Asp 
 225                230                235                240
Val Cys Ala Tyr Ala Ter 
                 245



<210> 6244
<211> 572
<212> DNA
<213> Rattus norvegicus
<308> AA894277
<400> 6244

aaaacggac  ccaatttat  tattgaaaa  atcacaatg  ctgggcatg  atcacacgc  60
tttggtccc  tcacttggg  ggaagaggc  ggaggatct  tgtgagttc  aggccaacc  120
ggtgtacat  gtgagttcc  ggccagcca  ggctacaca  tgagactct  tcttggaaa  180
ccaaaagaa  aggaaagat  ataacacac  gaatgccaa  atccctcct  ataaataaa  240
gtagtggat  aaaagacaa  atgaaggaa  gctataaaa  tggacagtt  ccagctgct  300
taagctctg  gtttgggcc  ggaggagga  ttgtgctct  ggagaatac  acatactaa  360
cctttctta  tctggcttg  gctttgtaa  ggagaccct  tgtccccta  aaacattcc  420
gaaaaacac  ggattctat  tttttcagc  atgctggcc  agagagtcc  tctgcctcc  480
gcggtgggg  aagatctac  ctcacagtc  cacgtccat  atacctgag  acacccaag  540
tccctcccc  tgtacgtga  ctcattcga  gc  572



<210> 6245
<211> 120
<212> PRT
<213> Rattus norvegicus
<308> BAB25613
<400> 6245

Met Val Arg Ile Leu Ala Asn Gly Glu Ile Val Gln Asp Asp Asp Pro 
  1               5                  10                  15
Arg Val Arg Thr Thr Thr Gln His Arg Ser Ser Ser Ser Gln Gln Gly 
             20                  25                  30
Phe Phe Asn Arg Gly His Gly Ala Pro Pro Gly Gly Pro Gly Pro Arg 
         35                  40                  45
Gln Gln Gln Ala Gly Ala Arg Leu Gly Ala Ala Gln Ser Pro Phe Ser 
     50                  55                  60
Asp Leu Asn Arg Gln Leu Val Asn Met Gly Phe Pro Gln Trp His Leu 
 65                  70                  75                  80
Gly Asn His Val Val Glu Pro Val Thr Ser Ile Leu Leu Leu Phe Leu 
                 85                  90                  95
Leu Met Met Leu Gly Val Arg Gly Leu Leu Leu Val Gly Leu Val Tyr 
             100                105                110
Leu Val Ser His Leu Ser Gln Arg 
         115                120



<210> 6246
<211> 572
<212> DNA
<213> Rattus norvegicus
<308> AA894277
<400> 6246

aaaacggac  ccaatttat  tattgaaaa  atcacaatg  ctgggcatg  atcacacgc  60
tttggtccc  tcacttggg  ggaagaggc  ggaggatct  tgtgagttc  aggccaacc  120
ggtgtacat  gtgagttcc  ggccagcca  ggctacaca  tgagactct  tcttggaaa  180
ccaaaagaa  aggaaagat  ataacacac  gaatgccaa  atccctcct  ataaataaa  240
gtagtggat  aaaagacaa  atgaaggaa  gctataaaa  tggacagtt  ccagctgct  300
taagctctg  gtttgggcc  ggaggagga  ttgtgctct  ggagaatac  acatactaa  360
cctttctta  tctggcttg  gctttgtaa  ggagaccct  tgtccccta  aaacattcc  420
gaaaaacac  ggattctat  tttttcagc  atgctggcc  agagagtcc  tctgcctcc  480
gcggtgggg  aagatctac  ctcacagtc  cacgtccat  atacctgag  acacccaag  540
tccctcccc  tgtacgtga  ctcattcga  gc  572



<210> 6247
<211> 120
<212> PRT
<213> Rattus norvegicus
<308> BAB25613
<400> 6247

Met Val Arg Ile Leu Ala Asn Gly Glu Ile Val Gln Asp Asp Asp Pro 
  1               5                  10                  15
Arg Val Arg Thr Thr Thr Gln His Arg Ser Ser Ser Ser Gln Gln Gly 
             20                  25                  30
Phe Phe Asn Arg Gly His Gly Ala Pro Pro Gly Gly Pro Gly Pro Arg 
         35                  40                  45
Gln Gln Gln Ala Gly Ala Arg Leu Gly Ala Ala Gln Ser Pro Phe Ser 
     50                  55                  60
Asp Leu Asn Arg Gln Leu Val Asn Met Gly Phe Pro Gln Trp His Leu 
 65                  70                  75                  80
Gly Asn His Val Val Glu Pro Val Thr Ser Ile Leu Leu Leu Phe Leu 
                 85                  90                  95
Leu Met Met Leu Gly Val Arg Gly Leu Leu Leu Val Gly Leu Val Tyr 
             100                105                110
Leu Val Ser His Leu Ser Gln Arg 
         115                120



<210> 6248
<211> 552
<212> DNA
<213> Rattus norvegicus
<308> AA894282
<400> 6248

tgtgttttt  ttttttttt  tttttttta  tggggagaa  gtttattta  caatttcac  60
tttcaaagt  agatcataa  ttttttaac  tttccctta  gatggatac  caagtgttt  120
atttggact  ctatctgct  tgaacttaa  tgagaagac  aatttgcta  ttggtctaa  180
tatataaga  acttttaca  aaatggaag  gttgcacat  aatcgggtt  cctaggatt  240
ataaagtca  aatgagtct  tgggtttat  aaaatctca  atagcttaa  tcttttcag  300
tataaaaaa  ctaatacaa  agattgact  tgtgtagtt  actagcata  cacttacat  360
gattcactg  cactttaag  ataagggca  ccttttaaa  actggagac  tttaaaatt  420
ggccataag  tttttcaaa  cagttcatg  tcatacatt  agcagattc  tactaaaaa  480
agtcttatt  tgtagaata  aggccaaga  aacattatg  tacaagctt  ttattacat  540
tatatacat  gc  552



<210> 6249
<211> 530
<212> DNA
<213> Rattus norvegicus
<308> AA894304
<400> 6249

taaagagct  tatttggct  gtacagcat  gactttcat  cattctcca  taatttgtc  60
ttaaagtgc  agacatttc  ttaatcacg  tgacatttg  taaagaaat  ggaactttt  120
tcaagacac  tcggtcatg  gtgaatact  ttcttacca  acccagaat  taagccccc  180
cacattgac  tgatgggtt  gacaacttg  gaacagatt  gaatcccct  tcaccttga  240
caccaaact  ggctgggac  aacacacct  gggattaag  agccatgct  tagagattg  300
gaaacaacc  ccccactgg  tgccgcctc  tcagggcca  gccagggct  cacggtttg  360
acaggtcca  cctttagag  aattaagac  tcgcctcct  tgccacctt  tatctcacc  420
tcccttact  acaaaagcc  ccaaagtca  tacaatgaa  ataaggagt  ggtttcccg  480
tacccaggt  ctaacgagg  tcagtacaa  tagggaaga  aaacgcaaaa  530



<210> 6250
<211> 4051
<212> DNA
<213> Homo sapiens
<308> M80899
<400> 6250

ttacccttc  taaagtgga  ggtgacctc  agggcccag  agctgacat  aagggccca  60
aagtggaca  caacacccc  gatgtggat  ttcatggcc  agactggca  ctgaagatg  120
ccaaggtga  aatgcccaa  ttcagcatg  ctggcttca  aggagaagg  ccagatgtg  180
atgtgaacc  gcccaaggc  gacattgat  tctcaggac  caaagtgga  gttgatgtt  240
ctgatgtga  tatcgaagg  ccagatgcg  aactaaagg  ccccaagtt  aagatgcct  300
agatgagca  caaagcccc  aagatctcc  tgcctgata  tgacttaaa  ctgaaagga  360
ccaaagtga  gggtgatgt  gatgttacc  ttcctaaag  ggaaggtga  ctcaagggc  420
cagaagctg  catcaaggg  ccaaaagtg  acatcaaca  ccctgatgt  gatgttcat  480
gcccagact  gcacctgaa  atgcccaag  tgaaaatgc  caaattcag  atgcctggc  540
tcaaaggag  aggtccaga  gtggatgtg  gcctgccca  ggccgacat  gatgtctcg  600
gacccaagg  ggacgttga  attccagat  tgaatatcg  aggtccaga  ccaaaactg  660
aggtcccca  ggtcaagat  cctgaaata  atatcaaag  tcccaagat  tccatacct  720
atgttgacc  ggatttgaa  ggacccaaa  taaaaggag  ttttgatgt  tctgtccct  780
aggttgaag  gactttgaa  ggcccagaa  tagatctta  aggtccacg  ctggatttc  840
aaggccctg  tgccaaact  agtggccca  ctttgaaga  gccatcgct  gagatatct  900
ctcctaaag  aactgctcc  gatgttgat  tgcatctca  ggcaccaaa  attggattt  960
caggtccga  gttagaagg  ggtgaagtg  acctcaagg  acccaaagt  gaagctcca  1020
gcttagatg  acacatgga  agcccagat  ttaacatcg  agggccaga  gttaaaatc  1080
ccaaattta  gaaacccaa  tttggattt  ggccaaaaa  ccccaaagc  gacatcaag  1140
caccttcac  ggatgtcac  gttcctgag  cagagctga  ccttgagac  cctgaaatt  1200
gtgttggtg  caagggcaa  aaaagtaag  ttaaaatgc  taaaattca  atgagtggt  1260
ctaagatta  ggccaaaaa  cagggattt  acctgaatg  tcctggggg  gaaattgat  1320
ccagcctca  ggctccgga  gtagatgtc  acatcgcag  gccggatgc  gcactcaaa  1380
tcgacgtga  atcgcccaa  accaagaaa  cgatgtttg  aaaaatgta  ttcccagat  1440
tagagtttg  cattaaatc  cctaaattt  aagctgagg  ccctctccc  agccccaaa  1500
tggagggtg  actccaggc  cctgatctg  aactttctt  gccagcgat  cacgtcgaa  1560
gtcttgaca  caaggcgaa  gctcccaag  tcaagatgc  agatgtgga  atctcagtg  1620
caaaaatag  gggtgacct  aaaggcccc  aagtgcagg  aaacttggg  gcacctgac  1680
tcaacatcg  aggcctaga  gctaaagtc  aaacaccgt  cttcggcat  tctgcccct  1740
aagtctcca  ccctgatgt  aatgtaaac  tgaaaggac  aaagataaa  ggtgatgtc  1800
ccagcgtgg  actggaagg  ccagatgta  atctgcaag  tccagaagc  aaaattaag  1860
tccccaagt  ttccatgcc  aagatcggc  tcccaggtg  gaaaatgga  ggtggggga  1920
ccgaggtcc  tgcccagct  ccctctctt  aaggagact  gagaggacc  gatgttaag  1980
tcgaagggc  cgatgtttc  ctaaagggg  caggagtag  cttaccttc  gtgaacctc  2040
ctatgccaa  agtctctgg  cctgacctt  atctgaact  gaaaggacc  agtttgaag  2100
gagacctgg  tgcatctgt  cccagcatg  aggtgcatg  tccagggct  aacctcagt  2160
gtgtcggtg  caaaatgca  gtgggagga  acggtgtga  agtgccagg  atcgatgcc  2220
caacaaagc  taacgttgg  gcaccagat  tgacactga  gggaccaag  ctgcaggga  2280
atctggctg  ctctggtga  atcaaatgc  ctaaagtat  cgtaggagc  cctgatcta  2340
gcttggagg  atccgaagg  agcattaaa  ttcccaaaa  gaagctgcc  caatttggt  2400
tctctactc  ggggtccga  ttgcacgtc  atgccaagg  gccacaggt  tctggcgaa  2460
tgaaggggc  aggtgtgga  gtgaacctg  aagggtctc  gatttcagc  ccgaatgtg  2520
actttaact  ggaaggacc  aaagtgaaa  ggagccttg  ggccactgg  gagatcaaa  2580
gccccactg  cggaggagg  cttccaggc  ttggtgttc  aggcctaga  ggaaacctc  2640
agatgcctg  aattaagtc  tctggatgt  atgtgaacc  gccaggcgt  aatgtgaaa  2700
tcccaactg  gcagatttc  gggcctgaa  tcaaaggtg  tctgaaagg  tcagaagta  2760
gtttccatg  ggctgctcc  gatatcagt  tgaaggggc  tgcctttaa  atggcatct  2820
ctgagtcag  ttttggcat  aacttgaag  gcccaaaaa  caaaggagg  gcggatgtt  2880
cagggggtg  cagtgcccc  gacatcagc  ttggtgaag  gcatttgag  gttaaaggt  2940
ccgggggtg  gtggaaggg  ccccaagtc  cctctgctc  caacttgga  acatctaag  3000
ttgctgggg  ccttcattt  tcaggacca  aggtggaag  aggtgtgaa  ggaggtcag  3060
ttggactcc  ggctcctgg  ctgagtgtg  ctgggcctc  aggtcactt  gaaagtgga  3120
ctggaaaag  aacattccc  aaaatgaag  tccccaaat  taccttctc  ggccgtgag  3180
tggttggca  agaaatggg  gtggatgtt  acttcccta  agcagaggc  agcatccaa  3240
ctggtgctg  agacggcga  tgggaagag  ctgaagtca  actgaaaaa  tccaagatc  3300
aaatgccca  gtttaattt  tccaaacct  aagggaaag  tggtgtcac  ggctcacca  3360
aagcatcaa  ttctgggtc  aaaggtgac  tgaaaagtt  aaaggccag  ctgggctct  3420
tggaaggag  ggcagaggc  gaagcctct  caccgaaag  caaattctc  ttatttaaa  3480
gtaagaagc  acggcaccg  tcaaattca  tcagtgatg  aagagagtt  tctggacct  3540
ccaccccga  ggggacgct  gagtttgaa  gtggggaag  gtctctgga  ggtgggaaa  3600
ttaaaggga  acacgggaa  ctgaaattc  gtacctttg  tggattggg  tcaaagagc  3660
aaggtcatt  tgaggtgac  gggagcgat  atgagacag  caagttaca  gggagtggg  3720
tgtccctgg  ctctaagaa  tcccgactg  cctcctctt  tagcaatga  agtgggaat  3780
aggttggca  ccagcttcc  gaggtggag  tgtcagttt  cacaaagaa  gagtagcag  3840
cctttgtat  tgtgtacat  tatatatat  taacaaaac  tcagccttg  gtggtgtgt  3900
cctatataa  ctccaaagg  aaacacacc  actgcctca  caatcatgc  aagaccttg  3960
ctggcccgg  ggcaagcgc  gaaaaaccg  ccgcctgta  gctcctgga  ctatacaga  4020
aggtaaaga  ttccaagtt  gtccggaat  c  4051



<210> 6251
<211> 2960
<212> PRT
<213> Homo sapiens
<308> Q09666
<400> 6251

Met Pro Gly Ile Lys Val Gly Gly Ser Gly Val Asn Val Asn Ala Lys 
  1               5                  10                  15
Gly Leu Asp Leu Gly Gly Arg Gly Gly Val Gln Val Pro Ala Val Asp 
             20                  25                  30
Ile Ser Ser Ser Leu Gly Gly Arg Pro Val Glu Val Gln Gly Pro Ser 
         35                  40                  45
Leu Glu Ser Gly Asp His Ala Lys Ile Lys Phe Pro Thr Met Lys Val 
     50                  55                  60
Pro Lys Phe Gly Val Ser Thr Gly Arg Glu Gly Gln Thr Pro Lys Ala 
 65                  70                  75                  80
Gly Leu Arg Val Ser Ala Pro Glu Val Ser Val Gly His Lys Gly Gly 
                 85                  90                  95
Lys Pro Gly Leu Thr Ile Gln Ala Pro Gln Leu Glu Val Ser Val Pro 
             100                105                110
Ser Ala Asn Ile Glu Gly Leu Glu Gly Lys Leu Lys Gly Pro Gln Ile 
         115                120                125
Thr Gly Pro Ser Leu Glu Gly Asp Leu Gly Leu Lys Gly Ala Lys Pro 
     130                135                140
Gln Gly His Ile Gly Val Asp Ala Ser Ala Pro Gln Ile Gly Gly Ser 
 145                150                155                160
Ile Thr Gly Pro Ser Val Glu Val Gln Ala Pro Asp Ile Asp Val Gln 
                 165                170                175
Gly Pro Gly Ser Lys Leu Asn Val Pro Lys Met Lys Val Pro Lys Phe 
             180                185                190
Ser Val Ser Gly Ala Lys Gly Glu Glu Thr Gly Ile Asp Val Thr Leu 
         195                200                205
Pro Thr Gly Glu Val Thr Val Pro Gly Val Ser Gly Asp Val Ser Leu 
     210                215                220
Pro Glu Ile Ala Thr Gly Gly Leu Glu Gly Lys Met Lys Gly Thr Lys 
 225                230                235                240
Val Lys Thr Pro Glu Met Ile Ile Gln Lys Pro Lys Ile Ser Met Gln 
                 245                250                255
Asp Val Asp Leu Ser Leu Gly Ser Pro Lys Leu Lys Gly Asp Ile Lys 
             260                265                270
Val Ser Ala Pro Gly Val Gln Gly Asp Val Lys Gly Pro Gln Val Ala 
         275                280                285
Leu Lys Gly Ser Arg Val Asp Ile Glu Thr Pro Asn Leu Glu Gly Thr 
     290                295                300
Leu Thr Gly Pro Arg Leu Gly Ser Pro Ser Gly Lys Thr Gly Thr Cys 
 305                310                315                320
Arg Ile Ser Met Ser Glu Val Asp Leu Asn Val Ala Ala Pro Lys Val 
                 325                330                335
Lys Gly Gly Val Asp Val Thr Leu Pro Arg Val Glu Gly Lys Val Lys 
             340                345                350
Val Pro Glu Val Asp Val Arg Gly Pro Lys Val Asp Val Ser Ala Pro 
         355                360                365
Asp Val Glu Ala His Gly Pro Glu Trp Asn Leu Lys Met Pro Lys Met 
     370                375                380
Lys Met Pro Thr Phe Ser Thr Pro Gly Ala Lys Gly Glu Gly Pro Asp 
 385                390                395                400
Val His Met Thr Leu Pro Lys Gly Asp Ile Ser Ile Ser Gly Pro Lys 
                 405                410                415
Val Asn Val Glu Ala Pro Asp Val Asn Leu Glu Gly Leu Gly Gly Lys 
             420                425                430
Leu Lys Gly Pro Asp Val Lys Leu Pro Asp Met Ser Val Lys Thr Pro 
         435                440                445
Lys Ile Ser Met Pro Asp Val Asp Leu His Val Lys Gly Thr Lys Val 
     450                455                460
Lys Gly Glu Tyr Asp Val Thr Val Pro Lys Leu Glu Gly Glu Leu Lys 
 465                470                475                480
Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Asp Val His Gly Pro 
                 485                490                495
Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Val 
             500                505                510
Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro Lys 
         515                520                525
Ala Asp Val Asp Ile Ser Gly Pro Lys Ile Asp Val Thr Ala Pro Asp 
     530                535                540
Val Ser Ile Glu Glu Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys 
 545                550                555                560
Met Pro Glu Met Asn Ile Lys Val Pro Lys Ile Ser Met Pro Asp Val 
                 565                570                575
Asp Leu His Leu Lys Gly Pro Asn Val Lys Gly Glu Tyr Asp Val Thr 
             580                585                590
Met Pro Lys Val Glu Ser Glu Ile Lys Val Pro Asp Val Glu Leu Lys 
         595                600                605
Ser Ala Lys Met Asp Ile Asp Val Pro Asp Val Glu Val Gln Gly Pro 
     610                615                620
Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Met 
 625                630                635                640
Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro Lys 
                 645                650                655
Ala Asp Val Asp Ile Ser Gly Pro Lys Val Gly Val Glu Val Pro Asp 
             660                665                670
Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys 
         675                680                685
Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Val 
     690                695                700
Asp Leu His Met Lys Gly Pro Lys Val Lys Gly Glu Tyr Asp Met Thr 
 705                710                715                720
Val Pro Lys Leu Glu Gly Asp Leu Lys Gly Pro Lys Val Asp Val Ser 
                 725                730                735
Ala Pro Asp Val Glu Met Gln Gly Pro Asp Trp Asn Leu Lys Met Pro 
             740                745                750
Lys Ile Lys Met Pro Lys Phe Ser Met Pro Ser Leu Lys Gly Glu Gly 
         755                760                765
Pro Glu Phe Asp Val Asn Leu Ser Lys Ala Asn Val Asp Ile Ser Ala 
     770                775                780
Pro Lys Val Asp Thr Asn Ala Pro Asp Leu Ser Leu Glu Gly Pro Glu 
 785                790                795                800
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His Phe Arg 
                 805                810                815
Ala Pro Lys Met Ser Leu Pro Asp Val Asp Leu Asp Leu Lys Gly Pro 
             820                825                830
Lys Met Lys Gly Asn Val Asp Ile Ser Ala Pro Lys Ile Glu Gly Glu 
         835                840                845
Met Gln Val Pro Asp Val Asp Ile Arg Gly Pro Lys Val Asp Ile Lys 
     850                855                860
Ala Pro Asp Val Glu Gly Gln Gly Leu Asp Trp Ser Leu Lys Ile Pro 
 865                870                875                880
Lys Met Lys Met Pro Lys Phe Ser Met Pro Ser Leu Lys Gly Glu Gly 
                 885                890                895
Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Val Ser Gly 
             900                905                910
Pro Lys Val Asp Ile Glu Ala Pro Asp Val Ser Leu Glu Gly Pro Glu 
         915                920                925
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His Phe Lys 
     930                935                940
Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro 
 945                950                955                960
Lys Val Lys Gly Asp Val Asp Val Ser Val Pro Lys Val Glu Gly Glu 
                 965                970                975
Met Lys Val Pro Asp Val Glu Ile Lys Gly Pro Lys Met Asp Ile Asp 
             980                985                990
Ala Pro Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro 
         995                1000                1005
Lys Met Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly 
     1010                1015                1020
Arg Glu Val Asp Val Asn Leu Pro Lys Ala Asp Ile Asp Val Ser Gly 
 1025                1030                1035                1040
Pro Lys Val Asp Val Glu Val Pro Asp Val Ser Leu Glu Gly Pro Glu 
                 1045                1050                1055
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His Phe Lys 
             1060                1065                1070
Ala Pro Lys Ile Ser Met Pro Asp Val Asp Leu Asn Leu Lys Gly Pro 
         1075                1080                1085
Lys Leu Lys Gly Asp Val Asp Val Ser Leu Pro Glu Val Glu Gly Glu 
     1090                1095                1100
Met Lys Val Pro Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Ser 
 1105                1110                1115                1120
Ala Pro Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro 
                 1125                1130                1135
Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly 
             1140                1145                1150
Pro Glu Val Asp Val Lys Leu Pro Lys Ala Asp Val Asp Val Ser Gly 
         1155                1160                1165
Pro Lys Met Asp Ala Glu Val Pro Asp Val Asn Ile Glu Gly Pro Asp 
     1170                1175                1180
Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Ser Ile Lys 
 1185                1190                1195                1200
Pro Gln Lys Ile Ser Ile Pro Asp Val Gly Leu His Leu Lys Gly Pro 
                 1205                1210                1215
Lys Met Lys Gly Asp Tyr Asp Val Thr Val Pro Lys Val Glu Gly Glu 
             1220                1225                1230
Ile Lys Ala Pro Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asn 
         1235                1240                1245
Ala Pro Asp Val Glu Val His Gly Pro Asp Trp His Leu Lys Met Pro 
     1250                1255                1260
Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly 
 1265                1270                1275                1280
Pro Glu Val Asp Met Asn Leu Pro Lys Ala Asp Leu Gly Val Ser Gly 
                 1285                1290                1295
Pro Lys Val Asp Ile Asp Val Pro Asp Val Asn Leu Glu Ala Pro Glu 
             1300                1305                1310
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Ser Met Asn Ile Gln 
         1315                1320                1325
Thr His Lys Ile Ser Met Pro Asp Val Gly Leu Asn Leu Lys Ala Pro 
     1330                1335                1340
Lys Leu Lys Thr Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp 
 1345                1350                1355                1360
Leu Lys Gly Pro Glu Ile Asp Val Lys Ala Pro Lys Met Asp Val Asn 
                 1365                1370                1375
Val Gly Asp Ile Asp Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro 
             1380                1385                1390
Lys Phe Lys Met Pro Glu Met His Phe Lys Ala Pro Lys Ile Ser Met 
         1395                1400                1405
Pro Asp Val Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly Asp Met 
     1410                1415                1420
Asp Val Ser Val Pro Lys Val Glu Gly Glu Met Lys Val Pro Asp Val 
 1425                1430                1435                1440
Asp Ile Lys Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Glu Val 
                 1445                1450                1455
His Asp Pro Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys 
             1460                1465                1470
Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn 
         1475                1480                1485
Leu Arg Lys Ala Asp Ile Asp Val Ser Gly Pro Ser Val Asp Thr Asp 
     1490                1495                1500
Ala Pro Asp Leu Asp Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Ser 
 1505                1510                1515                1520
Lys Phe Lys Met Pro Lys Leu Asn Ile Lys Ala Pro Lys Val Ser Met 
                 1525                1530                1535
Pro Asp Val Asp Leu Asn Leu Lys Gly Pro Lys Leu Lys Gly Glu Ile 
             1540                1545                1550
Asp Ala Ser Val Pro Glu Leu Glu Gly Asp Leu Arg Gly Pro Gln Val 
         1555                1560                1565
Asp Val Lys Gly Pro Leu Val Glu Ala Glu Val Pro Asp Val Asp Leu 
     1570                1575                1580
Glu Cys Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu 
 1585                1590                1595                1600
Met His Phe Lys Ala Pro Lys Ile Ser Met Pro Asp Val Asp Leu His 
                 1605                1610                1615
Leu Lys Gly Pro Lys Val Lys Gly Asp Ala Asp Val Ser Val Pro Lys 
             1620                1625                1630
Leu Glu Gly Asp Leu Thr Gly Pro Ser Val Gly Val Glu Val Pro Asp 
         1635                1640                1645
Val Glu Leu Glu Cys Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys 
     1650                1655                1660
Met Pro Asp Met His Phe Lys Ala Pro Lys Ile Ser Met Pro Asp Val 
 1665                1670                1675                1680
Asp Leu His Thr Leu Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu 
                 1685                1690                1695
Ala Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Thr Pro Asp Val Asp 
             1700                1705                1710
Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro 
         1715                1720                1725
Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val 
     1730                1735                1740
Asn Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val 
 1745                1750                1755                1760
Asp Val Pro Asp Val Asn Ile Glu Gly Pro Asp Ala Lys Leu Lys Gly 
                 1765                1770                1775
Pro Lys Phe Lys Met Pro Glu Met Ser Ile Lys Ala Pro Lys Ile Ser 
             1780                1785                1790
Met Pro Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Val Lys Gly Asp 
         1795                1800                1805
Val Asp Val Thr Leu Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu 
     1810                1815                1820
Ala Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Thr Pro Asp Val Asp 
 1825                1830                1835                1840
Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro 
                 1845                1850                1855
Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val 
             1860                1865                1870
Ser Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val 
         1875                1880                1885
Asp Ile Pro Asp Val Asn Ile Glu Gly Pro Asp Pro Lys Leu Lys Val 
     1890                1895                1900
Pro Lys Val Lys Met Pro Glu Ile Asn Ile Lys Ala Pro Lys Ile Ser 
 1905                1910                1915                1920
Ile Pro Asp Val Asp Leu Asp Leu Lys Gly Pro Lys Val Lys Gly Asp 
                 1925                1930                1935
Phe Asp Val Ser Val Pro Lys Val Glu Gly Thr Leu Lys Gly Pro Glu 
             1940                1945                1950
Val Asp Leu Lys Gly Pro Arg Leu Asp Phe Glu Gly Pro Asp Ala Lys 
         1955                1960                1965
Leu Ser Gly Pro Ser Leu Lys Met Pro Ser Leu Glu Ile Ser Ala Pro 
     1970                1975                1980
Lys Val Thr Ala Pro Asp Val Asp Leu His Leu Lys Ala Pro Lys Ile 
 1985                1990                1995                2000
Gly Phe Ser Gly Pro Lys Leu Glu Gly Gly Glu Val Asp Leu Lys Gly 
                 2005                2010                2015
Pro Lys Val Glu Ala Pro Ser Leu Asp Val His Met Asp Ser Pro Asp 
             2020                2025                2030
Ile Asn Ile Glu Gly Pro Asp Val Lys Ile Pro Lys Phe Lys Lys Pro 
         2035                2040                2045
Lys Phe Gly Phe Gly Pro Lys Ser Pro Lys Ala Asp Ile Lys Ser Pro 
     2050                2055                2060
Ser Leu Asp Val Thr Val Pro Glu Ala Glu Leu Asn Leu Glu Thr Pro 
 2065                2070                2075                2080
Glu Ile Ser Val Gly Gly Lys Gly Lys Lys Ser Lys Phe Lys Met Pro 
                 2085                2090                2095
Lys Ile His Met Ser Gly Pro Lys Ile Lys Ala Lys Lys Gln Gly Phe 
             2100                2105                2110
Asp Leu Asn Val Pro Gly Gly Glu Ile Asp Ala Ser Leu Lys Ala Pro 
         2115                2120                2125
Asp Val Asp Val Asn Ile Ala Gly Pro Asp Ala Ala Leu Lys Val Asp 
     2130                2135                2140
Val Lys Ser Pro Lys Thr Lys Lys Thr Met Phe Gly Lys Met Tyr Phe 
 2145                2150                2155                2160
Pro Asp Val Glu Phe Asp Ile Lys Ser Pro Lys Phe Lys Ala Glu Ala 
                 2165                2170                2175
Pro Leu Pro Ser Pro Lys Leu Glu Gly Glu Leu Gln Ala Pro Asp Leu 
             2180                2185                2190
Glu Leu Ser Leu Pro Ala Ile His Val Glu Gly Leu Asp Ile Lys Ala 
         2195                2200                2205
Lys Ala Pro Lys Val Lys Met Pro Asp Val Asp Ile Ser Val Pro Lys 
     2210                2215                2220
Ile Glu Gly Asp Leu Lys Gly Pro Lys Val Gln Ala Asn Leu Gly Ala 
 2225                2230                2235                2240
Pro Asp Ile Asn Ile Glu Gly Leu Asp Ala Lys Val Lys Thr Pro Ser 
                 2245                2250                2255
Phe Gly Ile Ser Ala Pro Gln Val Ser Ile Pro Asp Val Asn Val Asn 
             2260                2265                2270
Leu Lys Gly Pro Lys Ile Lys Gly Asp Val Pro Ser Val Gly Leu Glu 
         2275                2280                2285
Gly Pro Asp Val Asp Leu Gln Gly Pro Glu Ala Lys Ile Lys Phe Pro 
     2290                2295                2300
Lys Phe Ser Met Pro Lys Ile Gly Ile Pro Gly Val Lys Met Glu Gly 
 2305                2310                2315                2320
Gly Gly Ala Glu Val His Ala Gln Leu Pro Ser Leu Glu Gly Asp Leu 
                 2325                2330                2335
Arg Gly Pro Asp Val Lys Leu Glu Gly Pro Asp Val Ser Leu Lys Gly 
             2340                2345                2350
Pro Gly Val Asp Leu Pro Ser Val Asn Leu Ser Met Pro Lys Val Ser 
         2355                2360                2365
Gly Pro Asp Leu Asp Leu Asn Leu Lys Gly Pro Ser Leu Lys Gly Asp 
     2370                2375                2380
Leu Asp Ala Ser Val Pro Ser Met Lys Val His Ala Pro Gly Leu Asn 
 2385                2390                2395                2400
Leu Ser Gly Val Gly Gly Lys Met Gln Val Gly Gly Asp Gly Val Lys 
                 2405                2410                2415
Val Pro Gly Ile Asp Ala Thr Thr Lys Leu Asn Val Gly Ala Pro Asp 
             2420                2425                2430
Val Thr Leu Arg Gly Pro Ser Leu Gln Gly Asp Leu Ala Val Ser Gly 
         2435                2440                2445
Asp Ile Lys Cys Pro Lys Val Ser Val Gly Ala Pro Asp Leu Ser Leu 
     2450                2455                2460
Glu Ala Ser Glu Gly Ser Ile Lys Leu Pro Lys Met Lys Leu Pro Gln 
 2465                2470                2475                2480
Phe Gly Ile Ser Thr Pro Gly Ser Asp Leu His Val Asn Ala Lys Gly 
                 2485                2490                2495
Pro Gln Val Ser Gly Glu Leu Lys Gly Pro Gly Val Asp Val Asn Leu 
             2500                2505                2510
Lys Gly Ser Arg Ile Ser Ala Pro Asn Val Asp Phe Asn Leu Glu Gly 
         2515                2520                2525
Pro Lys Val Lys Gly Ser Leu Gly Ala Thr Gly Glu Ile Lys Gly Pro 
     2530                2535                2540
Thr Val Gly Gly Gly Leu Pro Gly Ile Gly Val Gln Gly Leu Glu Gly 
 2545                2550                2555                2560
Asn Leu Gln Met Pro Gly Ile Lys Ser Ser Gly Cys Asp Val Asn Leu 
                 2565                2570                2575
Pro Gly Val Asn Val Lys Leu Pro Thr Gly Gln Ile Ser Gly Pro Glu 
             2580                2585                2590
Ile Lys Gly Gly Leu Lys Gly Ser Glu Val Gly Phe His Gly Ala Ala 
         2595                2600                2605
Pro Asp Ile Ser Val Lys Gly Pro Ala Phe Asn Met Ala Ser Pro Glu 
     2610                2615                2620
Ser Asp Phe Gly Ile Asn Leu Lys Gly Pro Lys Ile Lys Gly Gly Ala 
 2625                2630                2635                2640
Asp Val Ser Gly Gly Val Ser Ala Pro Asp Ile Ser Leu Gly Glu Gly 
                 2645                2650                2655
His Leu Ser Val Lys Gly Ser Gly Gly Glu Trp Lys Gly Pro Gln Val 
             2660                2665                2670
Ser Ser Ala Leu Asn Leu Asp Thr Ser Lys Phe Ala Gly Gly Leu His 
         2675                2680                2685
Phe Ser Gly Pro Lys Val Glu Gly Gly Val Lys Gly Gly Gln Ile Gly 
     2690                2695                2700
Leu Gln Ala Pro Gly Leu Ser Val Ser Gly Pro Gln Gly His Leu Glu 
 2705                2710                2715                2720
Ser Gly Ser Gly Lys Val Thr Phe Pro Lys Met Lys Ile Pro Lys Phe 
                 2725                2730                2735
Thr Phe Ser Gly Arg Glu Leu Val Gly Arg Glu Met Gly Val Asp Val 
             2740                2745                2750
His Phe Pro Lys Ala Glu Ala Ser Ile Gln Ala Gly Ala Gly Asp Gly 
         2755                2760                2765
Glu Trp Glu Glu Ser Glu Val Lys Leu Lys Lys Ser Lys Ile Lys Met 
     2770                2775                2780
Pro Lys Phe Asn Phe Ser Lys Pro Lys Gly Lys Gly Gly Val Thr Gly 
 2785                2790                2795                2800
Ser Pro Glu Ala Ser Ile Ser Gly Ser Lys Gly Asp Leu Lys Ser Ser 
                 2805                2810                2815
Lys Ala Ser Leu Gly Ser Leu Glu Gly Glu Ala Glu Ala Glu Ala Ser 
             2820                2825                2830
Ser Pro Lys Gly Lys Phe Ser Leu Phe Lys Ser Lys Lys Pro Arg His 
         2835                2840                2845
Arg Ser Asn Ser Phe Ser Asp Glu Arg Glu Phe Ser Gly Pro Ser Thr 
     2850                2855                2860
Pro Thr Gly Thr Leu Glu Phe Glu Gly Gly Glu Val Ser Leu Glu Gly 
 2865                2870                2875                2880
Gly Lys Val Lys Gly Lys His Gly Lys Leu Lys Phe Gly Thr Phe Gly 
                 2885                2890                2895
Gly Leu Gly Ser Lys Ser Lys Gly His Tyr Glu Val Thr Gly Ser Asp 
             2900                2905                2910
Asp Glu Thr Gly Lys Leu Gln Gly Ser Gly Val Ser Leu Ala Ser Lys 
         2915                2920                2925
Lys Ser Arg Leu Ser Ser Ser Ser Ser Asn Asp Ser Gly Asn Lys Val 
     2930                2935                2940
Gly Ile Gln Leu Pro Glu Val Glu Leu Ser Val Ser Thr Lys Lys Glu 
 2945                2950                2955                2960



<210> 6252
<211> 621
<212> DNA
<213> Rattus norvegicus
<308> AA894305
<400> 6252

gttgattac  cattccata  acagttgta  aaagttcaa  tgaaagggt  tgcaggggc  60
ccatctcta  gttggttta  agtctatgg  agtttgtca  aggggcgag  cacagctcc  120
attctacaa  agtgtcttt  ccctgtttc  actagatca  agcaaaatg  cccgctacc  180
gaaagacca  tgatacatt  taaactctt  tttatatac  catcttttt  tttcttcat  240
atctttctt  ctctgaaga  gctgacagc  gctgatggg  agcacaaca  ttgggtccc  300
tttaccgct  tttatgtta  tacttcttc  ttgggtgct  acaaacatt  catgctaca  360
gttacaaat  acacatggg  gactccagc  cactgttat  ttaatttga  aatgaacac  420
aaagggaga  atttcttgt  ccggaaaca  aacactatg  tccttctgt  gaactttct  480
gtataggac  aacctgata  tatcactga  ctccattca  actggcaga  aagagagat  540
cgggaacac  agtatacaa  agtggaagg  gaactttca  ggacgtgac  tcccacgcg  600
tgtcacagg  actgcctca  g  621



<210> 6253
<211> 423
<212> DNA
<213> Homo sapiens
<308> AI221059
<400> 6253

ttttttttt  ttttttgtt  tgattttca  cgcctttat  aaaaaatat  aaaagttga  60
tacaggtcc  tatgcagtt  tacaaagtt  aagtgaaaa  aactgtagg  atgccatca  120
tgtgcgtgt  tgaagacta  ggaagcttg  caaaggggt  accctacaa  tcctgtcac  180
ttaacaatg  tccacagca  tgcttttcc  ccattttta  taggctagg  cattgcaca  240
taccttaag  tacttaaaa  agttttaat  cgttataaa  acgtacata  ttgtccttc  300
agtttgtta  catccttcc  tgaaagagc  gagctgttt  taggaagca  aacatttga  360
tcccattca  tgctgtttg  attacattt  cacaaagcc  gctttgaaa  ctggcaaac  420
ctg  423



<210> 6254
<211> 479
<212> DNA
<213> Rattus norvegicus
<308> AA894316
<400> 6254

gaatctagg  catctcagg  atccccggg  acaatcttg  ctcaggccc  tcccccgca  60
ctccctgca  ctgcatccc  cttgcctga  agcccttct  agctcggaa  ctgtgagct  120
aggagacat  gcacaaaat  ataaatgag  tgcggggag  ggctggaaa  agtgtgcaa  180
aaatacagg  caggggttg  ggatttagc  cagcggtag  gcgcttgcc  agcaaacac  240
aggccctgg  ttcggtccc  agctccaaa  aaaagaaaa  aaagaaaaa  gaaaaaaag  300
aaaacaggc  aatgctaca  gtgaggctt  gtggctggg  tgtgaccca  cgatatggg  360
agtggaggg  atcttttgt  tttggggac  ctctggagc  caacgatcc  ggctgtggt  420
caggggata  taaagttaa  atgctaccc  ccttttggc  ggttccttt  ccctcaacc  479



<210> 6255
<211> 569
<212> DNA
<213> Rattus norvegicus
<308> AA894318
<400> 6255

ttttttttt  aagtttcca  acaagaatt  attctttat  ttttttccc  taaaaaatg  60
accaggtac  atttttcct  ttttttgtt  tgttttgtt  ttcaagttt  agcaaatgc  120
tgttcccct  agccaagcc  caagagtta  gggttgagg  tgggtcaga  tcttaagtg  180
ggagtggag  aactgggaa  catatgact  aatgagggg  acccctcat  ccagctgag  240
taggtgggt  agagtctgg  caggtaaga  gaggttccc  agtccttag  cctgactct  300
tccctggac  ccttcctca  tcaggacac  aaagcaagg  gacaaaggc  ggaggagag  360
gacaactga  tctgagccc  aggtaagag  tggttaaac  cctgtgtta  acatacact  420
aattctctc  cgcgcaaca  accctacac  aacccaagt  tgggtgcac  cacacagtt  480
tacacacac  cactacaca  acaccacac  cacacatac  cacactggc  ttcgaagat  540
ggttgaagg  cagggaagg  aaaaggaat  569



<210> 6256
<211> 5771
<212> DNA
<213> Homo sapiens
<308> AB040972
<400> 6256

aatggcctg  gagtcagag  ggcagtgga  tcggcggcg  ggagccggg  cggccccgg  60
gagggaccg  cgcagggag  ggcgcggca  cggctgggg  gctgcgggc  ccagggccc  120
ctagtgttg  acacgaagc  gaacagcga  gagcctagc  gagcagggc  cagcctgag  180
caccctttg  ctgggttgg  ggcccgtgg  agggaggac  ggggaacca  ggggaggga  240
cgggacggg  cgggacgga  gggaccgga  cagcggcca  ctccgcgga  ccaatttgg  300
agcggggtg  gtgtgctag  gggaaagag  aaatctccg  agctccagt  tagtatggg  360
cctgtccca  gctgtgggg  ggagaggag  gagaaggga  ctgggaggc  gggcagggg  420
taagggatc  tccagaaga  ggagtccag  agtcaggtg  gtctgcctg  cttagttta  480
agagtctgc  aaggtctgc  ctctcccct  tgaagatag  gggctctag  ctgggggcc  540
aggggttgg  aagagagaa  aagtcgacc  tcctaccca  agtggtggt  cgtgggaac  600
gccccccta  cttgtgtgg  tgtatgtag  gacaaaata  agagcagct  gcagcagtt  660
tctttgcat  ggatgaggg  ggaaagcac  tggatagga  ttcatcctg  cactctcct  720
gatcatggt  gaaatggaa  tctttaata  tgaagggaa  gggagaatg  gccttgaag  780
tgataccta  accaatacc  acctcaccc  cctcccagg  ctcaaaagt  tctaaaggt  840
cagacgtat  ctgggactt  ttgtttttg  tggccttgc  ccctcagca  gttgggagc  900
gtagtcctt  ccagccaca  cctggcaca  ctgtttgat  ccagctgct  cccaccccc  960
gaacgaaga  tgaggcttg  cctactctg  cctgccccc  tcccctgca  tcctgcccc  1020
tgagtcagc  tgaagccat  gtctagagc  agactggct  ggtggcagg  gagtgaata  1080
agagcgtct  gttgacagg  tgggaactg  gagggctct  gggttaata  gcagatgcc  1140
ggtatgctg  ggtcaagta  ggcatcatg  catcccctg  cttccccag  gcaaggggt  1200
aagagggca  ctgggatga  ctggaagtg  tggtgctag  gaaaaggcc  ctcctgaat  1260
tgtatggct  gggtggagg  aagaagggt  gaaattagt  caggttgta  cttctgaca  1320
ggttggttg  aggtaggat  gtgcaggtt  cgattggtg  tctgccctt  ccagccatc  1380
cgcccacca  agggaacca  gattttctt  gggatccca  ttcttagga  aatttggtg  1440
aatgggata  tggggtaca  tgatgggaa  ttggtgtag  agagctttt  agtccctgg  1500
tacaaatct  tcctttctg  ctgctcccc  cccccacct  tgttcctga  tttcccttg  1560
acaattaat  tctctgctt  tctcatctg  gaaattttt  tctccactc  caggactgc  1620
gctcagatg  ctgggactt  cattctact  tttttgagc  ctgctgtgt  cttacccct  1680
tacttgggg  tggatggag  ggtgggaca  agatctgtc  tcaggaact  tatggtcgg  1740
ctagaagat  ccttaccca  aggagtgag  agaactgtt  gtgagctta  aggaagtag  1800
aacactgcc  taggtgagg  ctcagagaa  ggagagatg  ttatggtct  gggtggaca  1860
agcagactt  ctggaggag  tggcatttg  cctatccaa  gaggaaaag  cttgggtag  1920
cattcaaag  gcacttctt  aaggggaaa  agcaccgtg  atgtcagac  gcaaaagag  1980
aggctgacc  tgggggcag  tggctttca  cttgacatt  ccctcaccc  agtatgggc  2040
ggaatagtt  gtgaagacc  tcttatgca  cagtggttt  gggttttgg  gttgggtgt  2100
tgagcactg  gggaggggc  tggagaggt  ctccctagt  gcttccagc  gactgactg  2160
tgcggcctt  tctctagtt  gcagggcct  gcgggaggg  cctggaaag  gccttctgg  2220
agtgacccc  tccccttcc  cttcttgtt  ttggtcgga  ttgttgcct  ttgttaaag  2280
gacaggctg  tggaggcaa  ttggagttc  gggctgaaa  gccagctct  agctgactt  2340
aaatttgta  ctctgagga  cgctgatgg  gtataactg  gtgggagac  tctgccctt  2400
gtgccctag  atggcactt  tccctttgg  gatagacat  taagaagga  ttgtgcaat  2460
tggtggctt  gagtaagaa  gctgaattc  tcccctggc  gcctctcag  tgacacggt  2520
tcttggatc  tgggggtct  tcatccctt  ctccatgta  ggcaggagt  ctcaaatgg  2580
ggccctgac  agtagttat  ctacctcaa  tcacttgtc  catccttat  atactgagc  2640
aagacctgc  tctttgact  cttaggtag  ccaactctg  catctgtgc  ctggacccc  2700
agcctaccc  ttctgttcc  gaagagcct  tcacatggg  gaaggatgt  ctggagtgt  2760
ctattagcc  ataattggt  acaggcctt  ccgctggct  cagtgatcc  ggcttacgt  2820
tgttcttct  tcctcaggg  cctgctgag  tcaggagct  cacggaatg  tggcagtca  2880
cttgccagt  cagcaggca  ggatcagac  gcaagctag  ggcacgagg  atcagttgg  2940
aagagggga  gcacagcta  gcttgaggc  tcttcatcg  gatgtcccc  ggcccccca  3000
cccaggccc  gcataaagg  cgtgttggg  ggcccccct  acccaaggg  ggcttcatg  3060
gccacgtgc  ggcggagcc  tctccatcc  cagagccgg  ggctggccc  tcacagcct  3120
cagtcaggc  gggggccct  cagggtggc  tgctcatgg  ctacagccc  gcagggggg  3180
cgacatccc  cggggtcta  caggtatcc  tcttttccc  tccggctgg  acctctgag  3240
ctcataggg  cctgaaacg  caagcccca  ccactgagg  tccccggga  ctgaagaga  3300
gccctgggc  gggggccag  gagggacta  cccctgaag  accatctac  gtggggctc  3360
taggcccag  gggaccggg  ctgggacta  gtgtggcca  ccagcattt  tcccaccgt  3420
gcctctgtg  tgtggaaca  agaagtagt  tcacctcat  ttggacttc  ggggcctgg  3480
gtcccccct  ccccccatc  aatgcttcc  gcaatactt  gcacaccag  gactgggcc  3540
ccccagatc  agggggaca  gggtccctg  gggagtccc  agggccagc  cctccaggc  3600
agctgcaca  acttgacac  gatttgcac  gtcttgcac  aataggggg  aagagccca  3660
tggctgggg  gggcaatgg  ggtagcctc  ggcctaggg  gtcccctgg  actgccaat  3720
ggcacagtc  cgagcacac  ccccctggc  ctggacccc  aggcccctg  cccaccaag  3780
gaaggctgc  tcctgctgg  gaagcccca  atgtcagct  tgaggaaga  gggccagcc  3840
ctcggaggc  ccggggatc  ctgggccac  ctactgctg  caacagttc  gatgccaaa  3900
ccacaccct  ctggagcca  ctgctgcct  ggcccaaag  gcctgtttt  gacccaaca  3960
actgcggtc  catggggcg  aggctgaaa  gagcccgtc  cctgaagct  agccccctt  4020
gaagcctcc  gaaggggcc  ggcctgctg  gccccccca  tgcctcccc  gttcctacc  4080
ctgctgtca  ccgtaccct  ctgggcaac  ttgaggaat  attgctgcg  ggacgtttt  4140
caccatctg  ccacattga  ggcttcaca  cagaaattg  agctagtgg  tcatactgc  4200
cccagcacg  cacgctgcc  gtcactgtc  cattctttg  tgtttctga  caaaatgcc  4260
cggctccct  cctgggcat  gtggatctg  accccttgg  gaggaaggg  tacagcgtg  4320
ccaaggtgg  caccgtcca  gtgacctta  ttaacccca  ccagactgt  gtaaagatg  4380
tccttgtga  ctttgactt  tcggacatg  ctgctgccc  catgacctt  ctgcgccat  4440
gcctctttt  ggtgcctgt  ggtgaggag  gaaatgcta  ccccaccca  cgcctcctc  4500
gctacttgc  gcacctcag  ttccggagc  cccgctcag  ccgcttaag  ctgcatgga  4560
atatccgcc  gcttttttc  cgccggagc  tggagctgg  cacagggct  ccctacgaa  4620
tgcaggctg  gaccgaggc  cctcataat  cacgttatt  acctttgcc  tgattgcca  4680
cactctgaa  ccatgcggg  taatgacct  cccatcctg  tccatctta  agaacatat  4740
tggagagac  gcaagagac  cttcaggct  gaattaaag  cctcaccat  ctcacgccc  4800
aatggatta  ttgggtgtt  aaagcttct  attcttact  caccctgcc  tacttcggg  4860
actccatgt  cctgtcccc  cccttgggt  tcccaggcc  gcttaggta  tagggagga  4920
ctggagcta  cctgagatt  tctcaagtt  ccaggcaag  tatgccagc  ttgcctccc  4980
gtcctgggc  ggggccact  gttatttta  ttattttta  tttataatt  attcaaatt  5040
gattgcctt  gtaacctcc  acacctgat  attggcatc  ctcctcccc  cttcccact  5100
tcagatatt  ctccaacct  aggagttga  gaggcttat  cggtggggg  aggaggaga  5160
ctgctttcc  tcagctgag  gaagagggg  tattccaga  ggactgagt  agtagccaa  5220
gactcagct  cccctgtcc  tccccagtc  cttcacttc  cctaccctc  gacctatct  5280
tgaaagcca  gttatgcgt  tgtgtgtgt  cacaagctt  tctttgtgt  gtatgtgtg  5340
gtgagtgtg  atgtatgca  acacacagg  gttaaccac  cctcaccta  ggctccaga  5400
tccagttgt  cctctcctc  tacctgtgt  tccttgttt  ggggtcctg  ctgaagaag  5460
tgtccaggg  gcagagtca  ggccaagca  tggggtgcc  cctctcacc  ggccagact  5520
tgacccacc  acctcagct  gggtgaggg  cacccctca  actcagtca  gtggttcca  5580
actacccca  tccccactc  agactctga  ccagcctca  tcctaactc  tggggctgg  5640
ctgagggga  caagcattt  ctgaaactt  aaaaaacaa  gcaaatcaa  aacaggaaa  5700
aattgtacc  ggtactttt  tttagaaaa  aagattaaa  aagaaagaa  aaattcttg  5760
ttggaaact  g  5771



<210> 6257
<211> 501
<212> DNA
<213> Rattus norvegicus
<308> AA894330
<400> 6257

cagcagaaa  cacaaattt  ttaactctt  aatatatca  ttcgtcatt  accattacg  60
caagaatta  atacagtgt  ccatggtaa  ctgcagtgt  ttcaaaaca  tagaagatg  120
tgaaggtgt  attccactg  gctggagag  acaaatcac  atttcctca  atcttagtg  180
agaagacaa  ctggatcta  ggtaatact  caacaccac  tgctaagtt  aaagtgtaa  240
aaaaaaacc  attctacca  tatttgtgt  tttaaatac  tgtatgcca  gcagagctg  300
ttcacagaa  ggtaaaaga  attcaaagg  aaaagtgag  ccattacgt  tttcacaga  360
ctcattggc  ggttaacac  gctcaatac  tgtactgta  atatttgtt  taaatatat  420
ttgttttaa  tcatgtgct  attatcaga  aagcttcaa  ccatctatc  tacattcac  480
agcaacaat  tatctaaag  g  501



<210> 6258
<211> 533
<212> PRT
<213> Rattus norvegicus
<308> P15791
<400> 6258

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
  1               5                  10                  15
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
             20                  25                  30
Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
         115                120                125
Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
             180                185                190
Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
 305                310                315                320
Leu Lys Lys Pro Asp Gly Val Lys Ile Asn Asn Lys Ala Asn Val Val 
                 325                330                335
Thr Ser Pro Lys Glu Asn Ile Pro Thr Pro Ala Leu Glu Pro Gln Thr 
             340                345                350
Thr Val Ile His Asn Pro Asp Gly Asn Lys Glu Ser Thr Glu Ser Ser 
         355                360                365
Asn Thr Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile 
     370                375                380
Ile Lys Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe 
 385                390                395                400
Glu Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro 
                 405                410                415
Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr 
             420                425                430
Phe Glu Asn Ala Leu Pro Lys Ile Asn Lys Pro Ile His Thr Ile Ile 
         435                440                445
Leu Asn Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala 
     450                455                460
Tyr Ile Arg Leu Thr Gln Tyr Met Asp Gly Asn Gly Met Pro Lys Thr 
 465                470                475                480
Met Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp 
                 485                490                495
Gln Asn Ile His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys 
             500                505                510
Pro Pro Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser 
         515                520                525
Leu Trp Gln Asn Ile 
     530



<210> 6260
<211> 499
<212> PRT
<213> Homo sapiens
<308> Q13557
<400> 6260

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
  1               5                  10                  15
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
             20                  25                  30
Lys Ile Pro Thr Gly Gln Gly Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
         115                120                125
Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
             180                185                190
Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
 305                310                315                320
Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr 
                 325                330                335
Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys 
             340                345                350
Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala 
         355                360                365
Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala 
     370                375                380
Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
 385                390                395                400
Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn 
                 405                410                415
Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile 
             420                425                430
Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln 
         435                440                445
Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
     450                455                460
Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys Pro Pro 
 465                470                475                480
Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser Leu Trp 
                 485                490                495
Gln Asn Ile 
             500



<210> 6261
<211> 580
<212> DNA
<213> Rattus norvegicus
<308> AA894340
<400> 6261

acaagagca  aactgtctg  tgcagtcaa  cttattttg  cttataccc  gtggtattt  60
aataattgt  attcaaaca  atcaagtcc  cactcattt  cttctttta  gtcagtcac  120
gtataatca  tttggtaaa  tgtttgtat  ctctctctt  tattcatac  gaaataata  180
aatatttat  aaccaaact  tttgctgtt  agaaagcta  gaagattct  ctacataat  240
attttgata  gctaagaaa  cacacaaaa  tggcatttt  aaatggata  aaataggag  300
ttgctgaaa  aaaacataa  caataattt  tatctaaat  attttaact  agtgaatat  360
ttcatctga  aatatagcc  ctatcttag  atatagaag  gctcagatt  cctgtaata  420
agtaacgga  gtctcagag  actgaaaat  atttaaata  agacggtac  ctgagagca  480
ctacacagc  aggactgcg  ggttttatc  gaggcagac  gatgatgtc  gcatttcta  540
aatgtacct  tctctaggc  tgggaggat  ttaaatgact  580



<210> 6262
<211> 510
<212> DNA
<213> Rattus norvegicus
<308> AA894345
<400> 6262

gacatggca  tgcgggttt  atatacata  atgtagaat  tatatgtac  cacagttag  60
acggtcaag  tggggaagg  catcttggg  cagggagga  gctgggttc  ctcactgta  120
tctaatggc  tggctgtgt  gcattcaca  acccaaatg  gaaaggtga  cagtccctt  180
ctggattga  tggggtggt  gtcagtgca  aggaaacac  gtcgttaac  tatctcttg  240
ttggagaat  ccgaactgg  aagtggaaa  gttgcctac  atacccatt  tgggactct  300
caggttgcg  ttaaaacct  agggatctc  ttccccaat  cctacgctc  gggtcagta  360
atcccaaca  tctgtatct  gaaactgag  agcgagagt  ggcctgtct  tgcctgcat  420
cctggctca  gctcagcag  gcatggtcc  agcatagtc  ctccagagc  gaagttggg  480
acatcaaaa  ctggcttct  cactggggtt  510



<210> 6263
<211> 130
<212> PRT
<213> Rattus norvegicus
<308> CAB51573
<400> 6263

Met Ala Glu Tyr Gly Thr Leu Leu Gln Asp Leu Thr Asn Asn Ile Thr 
  1               5                  10                  15
Leu Glu Asp Leu Glu Gln Leu Lys Ser Ala Cys Lys Glu Asp Ile Pro 
             20                  25                  30
Ser Glu Lys Ser Glu Glu Ile Thr Thr Gly Ser Ala Trp Phe Ser Phe 
         35                  40                  45
Leu Glu Ser His Asn Lys Leu Asp Lys Asp Asn Leu Ser Tyr Ile Glu 
     50                  55                  60
His Ile Phe Glu Ile Ser Arg Arg Pro Asp Leu Leu Thr Met Val Val 
 65                  70                  75                  80
Asp Tyr Arg Thr Arg Val Leu Lys Ile Ser Glu Glu Asp Glu Leu Asp 
                 85                  90                  95
Thr Lys Leu Thr Arg Ile Pro Ser Ala Lys Lys Tyr Lys Asp Ile Ile 
             100                105                110
Arg Gln Pro Ser Glu Glu Glu Ile Ile Lys Leu Ala Pro Pro Pro Lys 
         115                120                125
Lys Ala 
     130



<210> 6264
<211> 1312
<212> DNA
<213> Homo sapiens
<308> L37385
<400> 6264

ggatccttt  ctggtccct  agatcaaac  ccatggagc  gccagcgtt  gatgccccc  60
cccacctgt  ctctggaga  actgtgctg  gaacatgta  cactgagcc  gagatgggg  120
tgagggcag  gagagggga  ccccctctt  cactcagtt  ttcctactc  gactgttgc  180
ctctaaacc  agggaggtt  aagaatgag  cccttaggt  ttaacacga  tcctgacac  240
accatctat  gggtccaac  tggttattg  aggcaacct  ccctctctc  ttggtgaag  300
acatcccaa  ccagaaaga  gttaactac  gtgttttcc  ttgcaccga  ccccacccc  360
attcaatcc  ggaaggact  acttaggaa  cccttcttt  ctagatatc  tggccccct  420
ggcttgtga  cacctccta  ccacatcac  acagtacag  gagtgaccc  agcctcctg  480
ctaccccaa  atgcccctc  ccaccctga  cgtgctaac  gtgtgtaca  atatattct  540
catatatgt  tattaaaac  gcactgcca  gtctgccct  ttttgtggt  tctagcatt  600
acttattgt  taggccaga  cgggggtgg  aggggaatg  cacagtgaa  ggagtgggc  660
gaatcaaat  gctacatag  ccaaagcaa  aaagaaggg  tttttcaaa  aacattaaa  720
tcacatgca  tctcagaga  tatttagac  aagttcaag  taggagctt  taggatgtg  780
gagtaaaac  ttaatggga  gggagggct  gctgctgga  gaaggaaga  gccagactg  840
ttagacagt  ctcttaact  ctagcccag  ctagcgtgc  ctgcccctc  ggccactgc  900
gcagacacc  gccttaaca  acacacctc  aggactcca  agttttgcc  taaaggacc  960
tcccaagtc  ccctttccc  gtctggctt  tcccttaag  agagagaga  acttgtaga  1020
ttgggtggg  ggaatgagc  tgaactgtc  ttccatttg  gatatgtta  attagagtg  1080
gagagagaa  aaggagcct  tcttatgga  gaaatggga  aagagagac  gggttcttt  1140
cagcagagt  tagtagttt  tctgtaagg  aaaataatc  aaaaagact  acctgccca  1200
ccactcctt  tattgctgt  agattgccc  tatcttgtg  tcttctgtc  gcagtgtgc  1260
cggccttgt  ctaacccgg  ataaaggtg  ttgattgta  tgccgcgga  cc  1312



<210> 6265
<211> 130
<212> PRT
<213> Homo sapiens
<308> Q15121
<400> 6265

Met Val Glu Tyr Gly Thr Leu Phe Gln Asp Leu Thr Asn Asn Ile Thr 
  1               5                  10                  15
Leu Glu Asp Leu Glu Gln Leu Lys Ser Ala Cys Lys Glu Asp Ile Pro 
             20                  25                  30
Ser Glu Lys Ser Glu Glu Ile Thr Thr Gly Ser Ala Trp Phe Ser Phe 
         35                  40                  45
Leu Glu Ser His Asn Lys Leu Asp Lys Asp Asn Leu Ser Ile Ile Glu 
     50                  55                  60
His Ile Phe Glu Ile Ser Arg Arg Pro Asp Leu Leu Thr Met Val Val 
 65                  70                  75                  80
Asp Tyr Arg Thr Arg Val Leu Lys Ile Ser Glu Glu Asp Glu Leu Asp 
                 85                  90                  95
Thr Lys Leu Thr Arg Ile Pro Ser Ala Lys Lys Tyr Lys Asp Ile Ile 
             100                105                110
Arg Gln Pro Ser Glu Glu Glu Ile Ile Lys Leu Gly Pro Pro Pro Lys 
         115                120                125
Lys Ala 
     130



<210> 6266
<211> 445
<212> DNA
<213> Rattus norvegicus
<308> AA899320
<400> 6266

ttttttttt  tttttttaa  taataaact  tttttattt  tccaataac  tttaaaatg  60
gaacattct  tgatttaat  cgtttttac  tccaagtaa  ttcttcatt  ggcctcagt  120
ccctttgaa  tagcatact  ttattccgg  aggcagtga  cttttcatc  tccttcctg  180
ctagataat  tccaaaggc  aatcccata  ggacgagta  atgaaccca  tgctcacgc  240
caagctgga  taaggtcat  ttgacttca  cccggtgtc  agcgcgacc  aggacagcc  300
cagggagct  ggccactgg  gacggcgga  gccgtgacc  aaggagctg  cactcgccg  360
gcccgccct  aggagaggg  tggcgatgg  caatcgacg  ctctctctc  cttctcacg  420
gtgagtcct  tacattttg  gtttt  445



<210> 6267
<211> 292
<212> DNA
<213> Homo sapiens
<308> XM_029314
<400> 6267

gttgccctt  gtctcgggg  cgctgtagg  gctgaggct  cagctatca  ggtgaactt  60
cttcagatt  tgcgggacc  ctgggttca  gttcttgtc  ctatgggat  tgtcattgg  120
tgttattta  acagaaaga  tgatgaacg  ctaactgcc  tccggaaca  gagtatgtt  180
tttaaaagg  aattgcaac  cagtgaaga  gttacctgg  agtaaagac  ggctagatt  240
tcgaatgtt  acattttaa  gttctgaga  aaataaaaa  atgaagaat  tg  292



<210> 6268
<211> 58
<212> PRT
<213> Homo sapiens
<308> XP_029314
<400> 6268

Met Val Asn Leu Leu Gln Ile Val Arg Asp His Trp Val His Val Leu 
  1               5                  10                  15
Val Pro Met Gly Phe Val Ile Gly Cys Tyr Leu Asp Arg Lys Ser Asp 
             20                  25                  30
Glu Arg Leu Thr Ala Phe Arg Asn Lys Ser Met Leu Phe Lys Arg Glu 
         35                  40                  45
Leu Gln Pro Ser Glu Glu Val Thr Trp Lys 
     50                  55



<210> 6269
<211> 392
<212> DNA
<213> Rattus norvegicus
<308> AA900199
<400> 6269

ttttttttt  tttttttaa  gacaggcat  agttctaat  attaccttt  tacgaaata  60
attcagtat  tacagcact  ttggaacat  catgtgctg  tagacaagt  ttttacctt  120
tgaagagct  ttcaatgat  ttgatcagg  aaatctctc  ttggtggaa  tacttctcc  180
gtctccaga  ttgtatcac  tgggaatag  ctgggcttc  tgccaccaa  ggcatatgg  240
ttagtagcc  catgatagt  gacgtaata  tggacgaac  agagaggta  gatcacatg  300
gaaacagtg  agagactgg  gcagtacgc  ttgaagatc  tgtacttcc  catggcccg  360
tcccgcaaa  agttattcc  caatcgctc  ag  392



<210> 6270
<211> 577
<212> DNA
<213> Homo sapiens
<308> AF035840
<400> 6270

cgcgcttaa  taactagtc  gtagttcga  ggtgcgccg  gtccttttg  gttggtacc  60
gcggcgaca  gacggggta  actccggat  agaaactgc  gctgcagca  ctgcgagag  120
tgagaaggc  atggctgaa  gaccaggag  tgagccctc  ggagccggt  ctgccccca  180
agaagatgg  gcctatgga  aaattctgg  ataaatttt  ggagaataa  tccccttgg  240
ggaaaatgg  ccatggggt  tacaaaaag  gtatctttg  tttcactca  gtacttgta  300
ctgtctgga  tattcatta  tacatgaag  atcatgttt  tgaaaaacc  tatggcata  360
ttgaaaaga  gtccagaat  ttccctggt  atacaattc  ggagactgg  gaagtaatt  420
caccaatga  agaatttcc  gatcaacat  attaaagat  atgtaaaaa  ttaaaaggc  480
tatgagcct  agtttgttc  tatattacc  tatttactg  attttctgg  aaagtaact  540
taataaagt  taatctcag  aattgtcaa  aaaaaaa  577



<210> 6271
<211> 127
<212> PRT
<213> Homo sapiens
<308> O95139
<400> 6271

Thr Gly Tyr Thr Pro Asp Glu Lys Leu Arg Leu Gln Gln Leu Arg Glu 
  1               5                  10                  15
Leu Arg Arg Arg Trp Leu Lys Asp Gln Glu Leu Ser Pro Arg Glu Pro 
             20                  25                  30
Val Leu Pro Pro Gln Lys Met Gly Pro Met Glu Lys Phe Trp Asn Lys 
         35                  40                  45
Phe Leu Glu Asn Lys Ser Pro Trp Arg Lys Met Val His Gly Val Tyr 
     50                  55                  60
Lys Lys Ser Ile Phe Val Phe Thr His Val Leu Val Pro Val Trp Ile 
 65                  70                  75                  80
Ile His Tyr Tyr Met Lys Tyr His Val Ser Glu Lys Pro Tyr Gly Ile 
                 85                  90                  95
Val Glu Lys Lys Ser Arg Ile Phe Pro Gly Asp Thr Ile Leu Glu Thr 
             100                105                110
Gly Glu Val Ile Pro Pro Met Lys Glu Phe Pro Asp Gln His His 
         115                120                125



<210> 6272
<211> 466
<212> DNA
<213> Rattus norvegicus
<308> AA900413
<400> 6272

ttttttttt  tttttttat  tcttaaggc  tatttaatg  aatccagtt  gcttaatgg  60
aaataaaaa  attgattag  attatatgg  gctgggggt  gggggtggc  tagcagtac  120
gcattggcc  agcatccac  gggccttag  ttctatctc  acaacacaa  acaaatgtg  180
cttcccagc  acccctccc  aaagaaata  ttactcata  attgcaagc  agcagaagt  240
gtcttataa  atgcatcct  ttaggagaa  cagtaggac  tgggagcat  ttcatgtta  300
tctttcttt  catagactt  aaacttgta  ttgatgcct  tttcctcct  gatctcaga  360
aggacgcct  ggtattctg  gagaagttt  tatttctcc  aatcaattt  tgggaagaa  420
gtgtcactt  caaactcct  catgatcct  gtcacaaag  gtctga  466



<210> 6273
<211> 187
<212> PRT
<213> Rattus norvegicus
<308> AAH05796
<400> 6273

Met Val Arg Pro Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
  1               5                  10                  15
Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
             20                  25                  30
Lys Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
         35                  40                  45
Asn Leu Val Ile Met Gly Arg Lys Thr Trp Phe Ser Ile Pro Glu Lys 
     50                  55                  60
Asn Arg Pro Leu Lys Asp Arg Ile Asn Ile Val Leu Ser Arg Glu Leu 
 65                  70                  75                  80
Lys Glu Pro Pro Arg Gly Ala His Phe Leu Ala Lys Ser Leu Asp Asp 
                 85                  90                  95
Ala Leu Arg Leu Ile Glu Gln Pro Glu Leu Ala Ser Lys Val Asp Met 
             100                105                110
Val Trp Ile Val Gly Gly Ser Ser Val Tyr Gln Glu Ala Met Asn Gln 
         115                120                125
Pro Gly His Leu Arg Leu Phe Val Thr Arg Ile Met Gln Glu Phe Glu 
     130                135                140
Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Gly Lys Tyr Lys Leu Leu 
 145                150                155                160
Pro Glu Tyr Pro Gly Val Leu Ser Glu Val Gln Glu Glu Lys Gly Ile 
                 165                170                175
Lys Tyr Lys Phe Glu Val Tyr Glu Lys Lys Asp 
             180                185



<210> 6274
<211> 484
<212> DNA
<213> Homo sapiens
<308> AW500760
<400> 6274

cacgaggcg  gccagggcc  aagcgactt  cgctacttg  attggtcgg  gtagctttg  60
gcggccgga  cttataaag  cacacatct  cgcgcctgt  cggcccctg  ttctgcgga  120
gctgaggca  gtaaaaaaa  ttgaagaag  gaatttcgc  gcattcttg  cctggcttc  180
tggcgtagc  agcaagttc  gaggtgtta  ccgctgctg  catgtttct  ttgctaaac  240
gcatcgtcg  tgtgtccca  aacatgggc  tcggcaaga  cggggacct  cccaggccg  300
cgctcagga  tgaattcag  tatttccag  gaatgacca  aacttcttc  gtagagggt  360
aacagaatc  ggtgattat  ggtaggaag  cctggttct  cattcctga  aagaatcga  420
ctttaaagg  taaaattaa  ttagttctc  gcagagaac  caaggaacc  ccacaagga  480
ctca  484



<210> 6276
<211> 269
<212> PRT
<213> Rattus norvegicus
<308> AAK30621
<400> 6276

Met Ala Asp His Met Met Ala Met Asn His Gly Arg Phe Pro Asp Gly 
  1               5                  10                  15
Thr Asn Gly Leu His His His Pro Ala His Arg Met Gly Met Gly Gln 
             20                  25                  30
Phe Pro Ser Pro His His His Gln Gln Gln Gln Pro Gln His Ala Phe 
         35                  40                  45
Asn Ala Leu Met Gly Glu His Ile His Tyr Gly Ala Gly Asn Met Asn 
     50                  55                  60
Ala Thr Ser Gly Ile Arg His Ala Met Gly Pro Gly Thr Val Asn Gly 
 65                  70                  75                  80
Gly His Pro Pro Ser Ala Leu Ala Pro Ala Ala Arg Phe Asn Asn Ser 
                 85                  90                  95
Gln Phe Met Gly Pro Pro Val Ala Ser Gln Gly Gly Ser Leu Pro Ala 
             100                105                110
Ser Met Gln Leu Gln Lys Leu Asn Asn Gln Tyr Phe Asn His His Pro 
         115                120                125
Tyr Pro His Asn His Tyr Met Pro Asp Leu His Pro Ala Ala Gly His 
     130                135                140
Gln Met Asn Gly Thr Asn Gln His Phe Arg Asp Cys Asn Pro Lys His 
 145                150                155                160
Ser Gly Gly Ser Ser Thr Pro Gly Gly Ala Gly Gly Ser Gly Thr Pro 
                 165                170                175
Gly Gly Ser Gly Gly Thr Ser Gly Gly Ala Gly Gly Ser Ser Ala Gly 
             180                185                190
Gly Ser Gly Gly Gly Ser Thr Met Pro Ala Ser Val Ala His Val Pro 
         195                200                205
Ala Ala Met Leu Pro Pro Asn Val Ile Asp Thr Asp Phe Ile Asp Glu 
     210                215                220
Glu Val Leu Met Ser Leu Val Ile Glu Met Gly Leu Asp Arg Ile Lys 
 225                230                235                240
Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu Phe Asp Phe Met Thr 
                 245                250                255
Asp Phe Val Cys Lys Gln Gln Pro Ser Arg Val Ser Cys 
             260                265



<210> 6277
<211> 899
<212> DNA
<213> Homo sapiens
<308> U65093
<400> 6277

gagggcaac  gaggggaaa  aaaagggaa  ggctccgaa  cggccccag  ggccgctgc  540
agacctcgg  gccgacatc  cgacagaag  gctttgcac  ccaggaagg  cccctctat  600
tgctgctga  ccggtcctg  acgcgacga  cccgccctc  gtcttcgga  cagaaatcg  660
aaaaacgga  ggactggaa  tggcagacc  tatgatggc  atgaaccac  ggcgcttcc  720
cgacggcac  aatgggctg  accatcacc  tgcccaccg  atgggcatg  ggcagttcc  780
gagccccca  caccaccag  agcagcagc  ccagcacgc  ttcaacgcc  taatgggcg  840
gcacataca  tacggcgcg  gcaacatga  tgccacgag  ggcatcagg  atgcgatgg  899



<210> 6278
<211> 270
<212> PRT
<213> Homo sapiens
<308> Q99967
<400> 6278

Met Ala Asp His Met Met Ala Met Asn His Gly Arg Phe Pro Asp Gly 
  1               5                  10                  15
Thr Asn Gly Leu His His His Pro Ala His Arg Met Gly Met Gly Gln 
             20                  25                  30
Phe Pro Ser Pro His His His Gln Gln Gln Gln Pro Gln His Ala Phe 
         35                  40                  45
Asn Ala Leu Met Gly Glu His Ile His Tyr Gly Ala Gly Asn Met Asn 
     50                  55                  60
Ala Thr Ser Gly Ile Arg His Ala Met Gly Pro Gly Thr Val Asn Gly 
 65                  70                  75                  80
Gly His Pro Pro Ser Ala Leu Ala Pro Ala Ala Arg Phe Asn Asn Ser 
                 85                  90                  95
Gln Phe Met Gly Pro Pro Val Ala Ser Gln Gly Gly Ser Leu Pro Ala 
             100                105                110
Ser Met Gln Leu Gln Lys Leu Asn Asn Gln Tyr Phe Asn His His Pro 
         115                120                125
Tyr Pro His Asn His Tyr Met Pro Asp Leu His Pro Ala Ala Gly His 
     130                135                140
Gln Met Asn Gly Thr Asn Gln His Phe Arg Asp Cys Asn Pro Lys His 
 145                150                155                160
Ser Gly Gly Ser Ser Thr Pro Gly Gly Ser Gly Gly Ser Ser Thr Pro 
                 165                170                175
Gly Gly Ser Gly Ser Ser Ser Gly Gly Gly Ala Gly Ser Ser Asn Ser 
             180                185                190
Gly Gly Gly Ser Gly Ser Gly Asn Met Pro Ala Ser Val Ala His Val 
         195                200                205
Pro Ala Ala Met Leu Pro Pro Asn Val Ile Asp Thr Asp Phe Ile Asp 
     210                215                220
Glu Glu Val Leu Met Ser Leu Val Ile Glu Met Gly Leu Asp Arg Ile 
 225                230                235                240
Lys Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu Phe Asp Phe Met 
                 245                250                255
Thr Asp Phe Val Cys Lys Gln Gln Pro Ser Arg Val Ser Cys 
             260                265                270



<210> 6280
<211> 269
<212> PRT
<213> Rattus norvegicus
<308> AAK30621
<400> 6280

Met Ala Asp His Met Met Ala Met Asn His Gly Arg Phe Pro Asp Gly 
  1               5                  10                  15
Thr Asn Gly Leu His His His Pro Ala His Arg Met Gly Met Gly Gln 
             20                  25                  30
Phe Pro Ser Pro His His His Gln Gln Gln Gln Pro Gln His Ala Phe 
         35                  40                  45
Asn Ala Leu Met Gly Glu His Ile His Tyr Gly Ala Gly Asn Met Asn 
     50                  55                  60
Ala Thr Ser Gly Ile Arg His Ala Met Gly Pro Gly Thr Val Asn Gly 
 65                  70                  75                  80
Gly His Pro Pro Ser Ala Leu Ala Pro Ala Ala Arg Phe Asn Asn Ser 
                 85                  90                  95
Gln Phe Met Gly Pro Pro Val Ala Ser Gln Gly Gly Ser Leu Pro Ala 
             100                105                110
Ser Met Gln Leu Gln Lys Leu Asn Asn Gln Tyr Phe Asn His His Pro 
         115                120                125
Tyr Pro His Asn His Tyr Met Pro Asp Leu His Pro Ala Ala Gly His 
     130                135                140
Gln Met Asn Gly Thr Asn Gln His Phe Arg Asp Cys Asn Pro Lys His 
 145                150                155                160
Ser Gly Gly Ser Ser Thr Pro Gly Gly Ala Gly Gly Ser Gly Thr Pro 
                 165                170                175
Gly Gly Ser Gly Gly Thr Ser Gly Gly Ala Gly Gly Ser Ser Ala Gly 
             180                185                190
Gly Ser Gly Gly Gly Ser Thr Met Pro Ala Ser Val Ala His Val Pro 
         195                200                205
Ala Ala Met Leu Pro Pro Asn Val Ile Asp Thr Asp Phe Ile Asp Glu 
     210                215                220
Glu Val Leu Met Ser Leu Val Ile Glu Met Gly Leu Asp Arg Ile Lys 
 225                230                235                240
Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu Phe Asp Phe Met Thr 
                 245                250                255
Asp Phe Val Cys Lys Gln Gln Pro Ser Arg Val Ser Cys 
             260                265



<210> 6281
<211> 899
<212> DNA
<213> Homo sapiens
<308> U65093
<400> 6281

gagggcaac  gaggggaaa  aaaagggaa  ggctccgaa  cggccccag  ggccgctgc  540
agacctcgg  gccgacatc  cgacagaag  gctttgcac  ccaggaagg  cccctctat  600
tgctgctga  ccggtcctg  acgcgacga  cccgccctc  gtcttcgga  cagaaatcg  660
aaaaacgga  ggactggaa  tggcagacc  tatgatggc  atgaaccac  ggcgcttcc  720
cgacggcac  aatgggctg  accatcacc  tgcccaccg  atgggcatg  ggcagttcc  780
gagccccca  caccaccag  agcagcagc  ccagcacgc  ttcaacgcc  taatgggcg  840
gcacataca  tacggcgcg  gcaacatga  tgccacgag  ggcatcagg  atgcgatgg  899



<210> 6282
<211> 270
<212> PRT
<213> Homo sapiens
<308> Q99967
<400> 6282

Met Ala Asp His Met Met Ala Met Asn His Gly Arg Phe Pro Asp Gly 
  1               5                  10                  15
Thr Asn Gly Leu His His His Pro Ala His Arg Met Gly Met Gly Gln 
             20                  25                  30
Phe Pro Ser Pro His His His Gln Gln Gln Gln Pro Gln His Ala Phe 
         35                  40                  45
Asn Ala Leu Met Gly Glu His Ile His Tyr Gly Ala Gly Asn Met Asn 
     50                  55                  60
Ala Thr Ser Gly Ile Arg His Ala Met Gly Pro Gly Thr Val Asn Gly 
 65                  70                  75                  80
Gly His Pro Pro Ser Ala Leu Ala Pro Ala Ala Arg Phe Asn Asn Ser 
                 85                  90                  95
Gln Phe Met Gly Pro Pro Val Ala Ser Gln Gly Gly Ser Leu Pro Ala 
             100                105                110
Ser Met Gln Leu Gln Lys Leu Asn Asn Gln Tyr Phe Asn His His Pro 
         115                120                125
Tyr Pro His Asn His Tyr Met Pro Asp Leu His Pro Ala Ala Gly His 
     130                135                140
Gln Met Asn Gly Thr Asn Gln His Phe Arg Asp Cys Asn Pro Lys His 
 145                150                155                160
Ser Gly Gly Ser Ser Thr Pro Gly Gly Ser Gly Gly Ser Ser Thr Pro 
                 165                170                175
Gly Gly Ser Gly Ser Ser Ser Gly Gly Gly Ala Gly Ser Ser Asn Ser 
             180                185                190
Gly Gly Gly Ser Gly Ser Gly Asn Met Pro Ala Ser Val Ala His Val 
         195                200                205
Pro Ala Ala Met Leu Pro Pro Asn Val Ile Asp Thr Asp Phe Ile Asp 
     210                215                220
Glu Glu Val Leu Met Ser Leu Val Ile Glu Met Gly Leu Asp Arg Ile 
 225                230                235                240
Lys Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu Phe Asp Phe Met 
                 245                250                255
Thr Asp Phe Val Cys Lys Gln Gln Pro Ser Arg Val Ser Cys 
             260                265                270



<210> 6283
<211> 512
<212> DNA
<213> Rattus norvegicus
<308> AA900503
<400> 6283

ttttttttt  tttttgtac  acgtcaggt  ttcaaacac  tccttgata  catcacttt  60
agacacatt  taaggactg  ctgaggcag  ttgagaatt  gtctagaac  ggtttttgt  120
tttttctct  ttctttttt  attttttcc  gctttagac  tgaaaagag  caggcaggc  180
atctgtgac  gagcagttt  agggaacaa  ctgagctat  tagtcagaa  gtgactggt  240
ggatctcat  aaaagtatc  gattgtgtg  agttggaag  ttaccaatc  tactttgta  300
attctgatt  cttttcacc  ttcgtatgt  atgctgaac  acttgtaga  ttgatttca  360
tgttgttgt  tactgcatt  agggagtat  ctaataagc  agatgaata  ttgaaccat  420
aaatgtcca  ttagagcac  gtttanatt  gccatagag  acactgcct  ccttaagtg  480
ggacatgaa  gtgctatta  caagttcaa  at  512



<210> 6284
<211> 1219
<212> PRT
<213> Rattus norvegicus
<308> Q63722
<400> 6284

Met Arg Ser Pro Arg Thr Arg Gly Arg Pro Gly Arg Pro Leu Ser Leu 
  1               5                  10                  15
Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
             20                  25                  30
Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
         35                  40                  45
Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
     50                  55                  60
Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
 65                  70                  75                  80
Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                 85                  90                  95
Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
             100                105                110
Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
         115                120                125
Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
     130                135                140
Thr Ile Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
 145                150                155                160
Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Ile 
                 165                170                175
Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp His Tyr Tyr 
             180                185                190
Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly 
         195                200                205
His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp 
     210                215                220
Met Gly Pro Glu Cys Asn Lys Ala Ile Cys Arg Gln Gly Cys Ser Pro 
 225                230                235                240
Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 
                 245                250                255
Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 
             260                265                270
His Gly Thr Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 
         275                280                285
Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln 
     290                295                300
Pro Cys Leu Asn Arg Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr 
 305                310                315                320
Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala 
                 325                330                335
Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys 
             340                345                350
Glu Thr Ser Ser Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 
         355                360                365
Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 
     370                375                380
His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 
 385                390                395                400
Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys 
                 405                410                415
Glu Ala Lys Pro Cys Val Asn Ala Arg Ser Cys Lys Asn Leu Ile Ala 
             420                425                430
Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp 
         435                440                445
Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys 
     450                455                460
Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala 
 465                470                475                480
Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 
                 485                490                495
Leu Asn Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 
             500                505                510
Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 
         515                520                525
Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala 
     530                535                540
Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys 
 545                550                555                560
Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp 
                 565                570                575
Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg 
             580                585                590
Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Glu 
         595                600                605
Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 
     610                615                620
Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Gly Asn Pro Cys Thr Asn 
 625                630                635                640
Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 
                 645                650                655
Asp Gly Trp Glu Gly Ala His Cys Glu Asn Asn Ile Asn Asp Cys Ser 
             660                665                670
Gln Asn Pro Cys His Tyr Gly Gly Thr Cys Arg Asp Leu Val Asn Asp 
         675                680                685
Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser 
     690                695                700
Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys 
 705                710                715                720
Tyr Asp Glu Val Asp Thr Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 
                 725                730                735
Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 
             740                745                750
Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Asp Ser Phe Thr Cys 
         755                760                765
Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Thr Gln Asn Thr Asn 
     770                775                780
Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly 
 785                790                795                800
Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp 
                 805                810                815
Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly 
             820                825                830
Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Gln Cys Ile Cys Pro Pro 
         835                840                845
Gly His Ser Gly Ala Lys Cys His Glu Val Ser Gly Arg Ser Cys Ile 
     850                855                860
Thr Met Gly Arg Val Ile Leu Asp Gly Ala Lys Trp Asp Asp Asp Cys 
 865                870                875                880
Asn Thr Cys Gln Cys Leu Asn Gly Arg Val Ala Cys Ser Lys Val Trp 
                 885                890                895
Cys Gly Pro Arg Pro Cys Arg Leu His Lys Gly His Gly Glu Cys Pro 
             900                905                910
Asn Gly Gln Ser Cys Ile Pro Val Leu Asp Asp Gln Cys Phe Val Arg 
         915                920                925
Pro Cys Thr Gly Ala Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val 
     930                935                940
Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn 
 945                950                955                960
Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr 
                 965                970                975
Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 
             980                985                990
Ser Ala Glu Tyr Ser Ile Tyr Ile Ala Cys Glu Pro Ser Leu Ser Ala 
         995                1000                1005
Asn Asn Glu Ile His Val Ala Ile Ser Ala Glu Asp Ile Arg Asp Asp 
     1010                1015                1020
Gly Asn Pro Val Lys Glu Ile Thr Asp Lys Ile Ile Asp Leu Val Ser 
 1025                1030                1035                1040
Lys Arg Asp Gly Asn Ser Ser Leu Ile Ala Ala Val Ala Glu Val Arg 
                 1045                1050                1055
Val Gln Arg Arg Pro Leu Lys Asn Arg Thr Asp Phe Leu Val Pro Leu 
             1060                1065                1070
Leu Ser Ser Val Leu Thr Val Ala Trp Val Cys Cys Leu Val Thr Ala 
         1075                1080                1085
Phe Tyr Trp Cys Val Arg Lys Arg Arg Arg Lys Pro Ser Ser His Thr 
     1090                1095                1100
His Ser Ala Pro Glu Asp Asn Thr Thr Asn Asn Val Arg Glu Gln Leu 
 1105                1110                1115                1120
Asn Gln Ile Lys Asn Pro Ile Glu Lys His Gly Ala Asn Thr Val Pro 
                 1125                1130                1135
Ile Lys Asp Tyr Glu Asn Lys Asn Ser Lys Met Ser Lys Ile Arg Thr 
             1140                1145                1150
His Asn Ser Glu Val Glu Glu Asp Asp Met Asp Lys His Gln Gln Lys 
         1155                1160                1165
Val Arg Phe Ala Lys Gln Pro Val Tyr Thr Leu Val Asp Arg Glu Glu 
     1170                1175                1180
Lys Val Pro Gln Arg Thr Pro Thr Lys His Pro Asn Trp Thr Asn Lys 
 1185                1190                1195                1200
Gln Asp Asn Arg Asp Leu Glu Ser Ala Gln Ser Leu Asn Arg Met Glu 
                 1205                1210                1215
Tyr Ile Val 
             1220



<210> 6285
<211> 5896
<212> DNA
<213> Homo sapiens
<308> NM_000214
<400> 6285

ctgcggccg  cccgcgagc  aggctgggt  ttttttttt  tcccctccc  ccccccttt  60
tccatgcag  tgatctaaa  gggaataaa  ggctgcgca  aatcataat  ataaaagaa  120
gggagcgcg  gagaaggaa  gaaagccgg  aggtggaag  ggaggggga  cgtctcaaa  180
aagcgatca  aataataaa  ggaggccgg  ctctttgcc  tctggaacg  gccgctctt  240
aaagggctt  tgaaaagtg  tgttgtttt  cagtcgtgc  tgctccaat  ggcggagta  300
attagagcc  ggacgcggc  gccgcaggg  cagcggcga  ggcagcacc  gcggcagca  360
cagcgcgaa  agcagcggc  gcgtcccga  tgcccgcgg  gcgcggcgc  gcgatgcgt  420
ccccacgga  gcgcggccg  tccgggcgc  ccctaagcc  cctgctcgc  ctgctctgt  480
ccctgcgag  caaggtgtg  ggggcctcg  gtcagttcg  gttggagat  ctgtccatg  540
agaacgtga  cggggagct  cagaacggg  actgctgcg  cggcgcccg  aacccggga  600
accgcaagt  cacccgcga  gagtgtgac  catacttca  agtgtgcct  aaggagtat  660
agtcccgcg  cacggccgg  gggccctgc  gcttcggct  agggtccac  cctgtcatc  720
ggggcaaca  cttcaacct  aaggccagc  gcggcaacg  ccgcaaccg  atcgtgctg  780
ctttcagtt  cgcctggcc  aggtcctat  cgttgcttg  ggaggcgtg  gattccagt  840
atgacaccg  tcaacctga  agtattatt  aaaaggctt  tcactcggg  atgatcaac  900
ccagccggc  gtggcagac  ctgaagcag  acacgggcg  tgcccactt  gagtatcag  960
tccgcgtga  ctgtgatga  tactactat  gctttggct  caataagtt  tgccgcccc  1020
gagatgact  ctttggaca  tatgcctgt  accagaatg  caacaaaac  tgcatggaa  1080
gctggatgg  ccccgaatg  aacagagct  tttgccgac  aggctgcag  cctaagcat  1140
ggtcttgca  actcccagg  gactgcagg  gccagtatg  ctggcaagg  ctgtactgt  1200
ataagtgca  cccacaccc  ggatgcgtc  acggcatct  taatgagcc  tggcagtgc  1260
tctgtgaga  caactgggg  ggccagctc  gtgacaaag  tctcaatta  tgtgggact  1320
atcagccgt  tctcaacgg  ggaacttgt  gcaacacag  ccctgacaa  tatcagtgt  1380
cctgccctg  ggggtattc  ggacccaac  gtgaaattg  tgagcacgc  tgcctctct  1440
atccctgtc  caacagagg  agctgtaag  agacctccc  gggctttga  tgtgagtgt  1500
ccccaggct  gaccggccc  acatgctct  caaacattg  tgactgttc  cctaataac  1560
gttcccacg  gggcacctg  caggacctg  ttaacggat  taagtgtgt  tgcccccca  1620
agtggactg  gaaaacgtg  cagttagat  caaatgaat  tgaggccaa  ccttgtgta  1680
acgccaaat  ctgtaagaa  ctcattgcc  gctactact  cgactgtct  cccggctgg  1740
tgggtcaga  ttgtgacat  aatattaat  actgccttg  ccagtgtca  aatgacgcc  1800
cctgtcggg  tttggttaa  ggttatcgc  gtatctgtc  acctggcta  gcaggcgat  1860
actgtgaga  agacatcga  gaatgtgcc  gcaacccct  tttgaatgg  ggtcactgt  1920
agaatgaaa  caacagatt  cagtgtctg  gtcccactg  tttctctgg  aacctctgt  1980
agctggaca  cgattattg  gagcctaat  cctgccaga  cggtgccca  tgctacaac  2040
gtgccagtg  ctatttctg  aagtgcccc  aggactatg  gggcaagaa  tgctcacac  2100
tgaaagacc  ctgccgcac  accccctgt  aagtgattg  cagctgcac  gtggccatg  2160
cttccaacg  cacacctga  ggggtgcgg  atatttcct  caacgtctg  ggtcctcac  2220
ggaagtgca  gagtcagtc  ggaggcaaa  tcacctgtg  ctgtaacaa  ggcttcacg  2280
gaacatact  ccatgaaaa  attaatgac  gtgagagca  cccttgtag  aacggtggc  2340
cttgcatcg  tggtgtcaa  tcctacaag  gcatctgta  tgacggctg  gagggggcc  2400
actgtgaaa  caatattaa  gactgcagc  agaacccct  ccacaatgg  ggcacgtgt  2460
gcgacctgg  caatgactt  tactgtgac  gtaaaaatg  gtggaaagg  aagacctgc  2520
actcacgtg  cagtcagtg  gatgaggcc  cgtgcaaca  cggtggcac  tgctatgat  2580
agggggatg  ttttaagtg  atgtgtcct  gcggctggg  aggaacaac  tgtaacata  2640
cccgaaaca  tagctgcct  cccaacccc  gccataatg  gggcacatg  gtggtcaac  2700
gcgagtcct  tacgtgcgt  tgcaaggaa  gctgggagg  gcccatctg  gctcagaat  2760
ccaatgact  cagccctca  ccctgttac  acagcggca  ctgtgtgga  ggagacaac  2820
ggtaccggt  cgaatgtgc  ccgggtttt  ctgggcccg  ctgcagaat  aacatcaat  2880
aatgccagt  ttcaccttg  gcctttgga  cgacctgtg  ggatgagat  aatggctac  2940
ggtgtgtct  ccctccagg  cacagtggt  ccaagtgcc  ggaagtttc  gggagacct  3000
gcatcacca  ggggagtgt  ataccagat  gggccaaat  ggatgatga  tgtaatacc  3060
gccagtgcc  gaatggacg  atcgcctgc  caaaggtct  gtgtggccc  cgaccttgc  3120
tgctccaca  agggcacag  gagtgcccc  gcgggcaga  ctgcatccc  atcctggac  3180
accagtgct  cgtccaccc  tgcactggt  tgggcgagt  tcggtcttc  agtctccag  3240
cggtgaaga  aaagtgcac  tctgactcc  attaccagg  taactgtgc  aacatcaca  3300
ttaccttta  caaggagat  atgtcacca  gtcttacta  ggagcacat  tgcagtgaa  3360
tgaggaatt  gaatatttt  aagaatgtt  ccgctgaat  ttcaatcta  atcgcttgc  3420
agccttccc  ttcagcgaa  aatgaaata  atgtggcca  ttctgctga  gatatacgg  3480
atgatggga  cccgatcaa  gaaatcact  acaaaataa  cgatcttgt  agtaaacgt  3540
atggaaaca  ctcgctgat  gctgccgtt  cagaagtaa  agttcagag  cggcctctg  3600
agaacagaa  agatttcct  gttcccttg  tgagctctg  cttaactgt  gcttggatc  3660
gttgcttgg  gacggcctt  tactggtgc  tgcggaagc  gcggaagcc  ggcagccac  3720
cacactcag  ctctgagga  aacaccacc  acaacgtgc  ggagcagct  aaccagatc  3780
aaaacccca  tgagaaaca  ggggccaac  cggtcccca  caaggatta  gagaacaag  3840
actccaaaa  gtctaaaat  aggacacac  attctgaag  agaagagga  gacatggac  3900
aacaccagc  gaaagcccg  tttgccaag  agccggcgt  tacgctggt  gacagagaa  3960
agaagcccc  caacggcac  ccgacaaaa  acccaaact  gacaaacaa  caggacaac  4020
gagacttgg  aagtgccca  agcttaaac  gaatggagt  catcgtata  cagaccgcg  4080
gcactgccg  cgctaggta  agtctgagg  cttgtagtt  tttaaactg  cgtgtcata  4140
tcgagtctg  ggccgttgc  gacttagaa  ccctgtgtt  atttaagtt  tgacaagct  4200
gcttacact  gcaatggta  tttctgtgg  tggctggga  atcgagtgc  gcatctcac  4260
gctatgcaa  aagctagtc  acagtaccc  ggttgtgtg  ccccttgca  ccgacacgg  4320
ctcggatca  gctcccagg  gcctgccca  ccccctggt  tttgagctc  cacttctgc  4380
agatgtcct  atggtgatg  agtcttaga  catagtttt  tttatattt  ttgactctt  4440
agttgtttt  gtatattgg  tttatgatg  cgtacaagt  gttctgtat  tgaaagtgc  4500
tttgcagct  agaaccaca  caacgatca  aaatgactt  attatttat  tttttaatt  4560
tatttttgt  gttggggga  gggagactt  gatgtcagc  gttgctggt  aaatgaaga  4620
tttaaagaa  aaaatgtca  aagtagaac  ttgtatagt  atgtaaata  ttctttttt  4680
ttaatcact  tgtatattt  atttattaa  ttaataatc  agagcctta  aacatcatt  4740
ctttttatt  atatgtatg  gtttagaat  gaaggtttt  gatagcatt  taagcgtat  4800
gctttattt  tttgaactc  tctcattac  tgttgccta  aagccaaaa  taaggtgtt  4860
gaaaatagt  tattttaaa  caataggat  ggcttctgt  cccagaata  tgatggaat  4920
ttttttgta  gacgtcaga  gtttaaaac  ccttctata  catcactta  aacacgttt  4980
aaggactga  tgaggcagt  tgaggatta  tttagaaca  gtttttttg  ttgtttgtt  5040
tttgttttt  tgctttaga  ttgaaaaga  acaggcagg  gatctgctg  agagcagta  5100
gggaacaag  tgagctatg  cttaacata  ccaaaatgt  agtggttga  tatgattaa  5160
aatatcaaa  taattgtgt  aacttggaa  cacaccaat  tgactttgt  aattctgat  5220
tcttttcac  attcgtaca  aatactgaa  cacttgtag  tttgatttt  tttttaatc  5280
actgcattt  gggagtatt  taataagct  gttgaatac  tgaaccata  aatgtccag  5340
aagatcact  tttagattt  ccatagagt  cactgcctg  cttaagtga  gaaatcaaa  5400
tgctattac  aagttcaag  tcaaaaagg  ttataaaac  gagtaatct  gttggttca  5460
cattgagac  gtgaagata  tttgtattg  cctattagt  ttatatgaa  atacaaatg  5520
atctttgat  tgttgttct  ggcaataaa  tttgaaaag  aatatttat  aaatttttt  5580
gtatgaaaa  atggaacag  gtggctctt  tgagcttac  tagttctac  ggctttgcc  5640
tgtgcttct  ccaccctgc  gagtctgtt  tggtaatcg  ggtataata  gctctgcct  5700
acagaggga  ggaggaaga  ctgaaaggc  tttcaacca  aaaactcat  tggagttct  5760
aaagacctg  ggctgctgt  aagctggaa  tgcgggagc  ccatctagg  gagccttga  5820
tcccttgtt  ttcaacagc  agtgtgaat  ctgcttgaa  aaacaccac  ggattaatg  5880
aaaaaaaaa  aaaaaa  5896



<210> 6286
<211> 1218
<212> PRT
<213> Homo sapiens
<308> P78504
<400> 6286

Met Arg Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu 
  1               5                  10                  15
Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
             20                  25                  30
Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
         35                  40                  45
Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
     50                  55                  60
Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
 65                  70                  75                  80
Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                 85                  90                  95
Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
             100                105                110
Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
         115                120                125
Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
     130                135                140
Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
 145                150                155                160
Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Val 
                 165                170                175
Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr 
             180                185                190
Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly 
         195                200                205
His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp 
     210                215                220
Met Gly Pro Glu Cys Asn Arg Ala Ile Cys Arg Gln Gly Cys Ser Pro 
 225                230                235                240
Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 
                 245                250                255
Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 
             260                265                270
His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 
         275                280                285
Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln 
     290                295                300
Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr 
 305                310                315                320
Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala 
                 325                330                335
Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys 
             340                345                350
Glu Thr Ser Leu Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 
         355                360                365
Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 
     370                375                380
His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 
 385                390                395                400
Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys 
                 405                410                415
Glu Ala Lys Pro Cys Val Asn Ala Lys Ser Cys Lys Asn Leu Ile Ala 
             420                425                430
Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp 
         435                440                445
Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys 
     450                455                460
Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala 
 465                470                475                480
Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 
                 485                490                495
Leu Asn Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 
             500                505                510
Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 
         515                520                525
Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala 
     530                535                540
Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys 
 545                550                555                560
Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp 
                 565                570                575
Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg 
             580                585                590
Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Gln 
         595                600                605
Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 
     610                615                620
Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn 
 625                630                635                640
Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 
                 645                650                655
Asp Gly Trp Glu Gly Ala Tyr Cys Glu Thr Asn Ile Asn Asp Cys Ser 
             660                665                670
Gln Asn Pro Cys His Asn Gly Gly Thr Cys Arg Asp Leu Val Asn Asp 
         675                680                685
Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser 
     690                695                700
Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys 
 705                710                715                720
Tyr Asp Glu Gly Asp Ala Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 
                 725                730                735
Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 
             740                745                750
Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Glu Ser Phe Thr Cys 
         755                760                765
Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn 
     770                775                780
Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly 
 785                790                795                800
Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp 
                 805                810                815
Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly 
             820                825                830
Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Arg Cys Val Cys Pro Pro 
         835                840                845
Gly His Ser Gly Ala Lys Cys Gln Glu Val Ser Gly Arg Pro Cys Ile 
     850                855                860
Thr Met Gly Ser Val Ile Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys 
 865                870                875                880
Asn Thr Cys Gln Cys Leu Asn Gly Arg Ile Ala Cys Ser Lys Val Trp 
                 885                890                895
Cys Gly Pro Arg Pro Cys Leu Leu His Lys Gly His Ser Glu Cys Pro 
             900                905                910
Ser Gly Gln Ser Cys Ile Pro Ile Leu Asp Asp Gln Cys Phe Val His 
         915                920                925
Pro Cys Thr Gly Val Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val 
     930                935                940
Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn 
 945                950                955                960
Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr 
                 965                970                975
Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 
             980                985                990
Ser Ala Glu Tyr Ser Ile Tyr Ile Ala Cys Glu Pro Ser Pro Ser Ala 
         995                1000                1005
Asn Asn Glu Ile His Val Ala Ile Ser Ala Glu Asp Ile Arg Asp Asp 
     1010                1015                1020
Gly Asn Pro Ile Lys Glu Ile Thr Asp Lys Ile Ile Asp Leu Val Ser 
 1025                1030                1035                1040
Lys Arg Asp Gly Asn Ser Ser Leu Ile Ala Ala Val Ala Glu Val Arg 
                 1045                1050                1055
Val Gln Arg Arg Pro Leu Lys Asn Arg Thr Asp Phe Leu Val Pro Leu 
             1060                1065                1070
Leu Ser Ser Val Leu Thr Val Ala Trp Ile Cys Cys Leu Val Thr Ala 
         1075                1080                1085
Phe Tyr Trp Cys Leu Arg Lys Arg Arg Lys Pro Gly Ser His Thr His 
     1090                1095                1100
Ser Ala Ser Glu Asp Asn Thr Thr Asn Asn Val Arg Glu Gln Leu Asn 
 1105                1110                1115                1120
Gln Ile Lys Asn Pro Ile Glu Lys His Gly Ala Asn Thr Val Pro Ile 
                 1125                1130                1135
Lys Asp Tyr Glu Asn Lys Asn Ser Lys Met Ser Lys Ile Arg Thr His 
             1140                1145                1150
Asn Ser Glu Val Glu Glu Asp Asp Met Asp Lys His Gln Gln Lys Ala 
         1155                1160                1165
Arg Phe Ala Lys Gln Pro Ala Tyr Thr Leu Val Asp Arg Glu Glu Lys 
     1170                1175                1180
Pro Pro Asn Gly Thr Pro Thr Lys His Pro Asn Trp Thr Asn Lys Gln 
 1185                1190                1195                1200
Asp Asn Arg Asp Leu Glu Ser Ala Gln Ser Leu Asn Arg Met Glu Tyr 
                 1205                1210                1215
Ile Val 
             1220



<210> 6287
<211> 494
<212> DNA
<213> Rattus norvegicus
<308> AA900582
<400> 6287

cggccgctc  aacatcagc  gaggtagcc  ggggttggt  ccagaggcc  actgacacg  60
tgggtttct  aggtctggt  cagtggaca  aatcttctt  ttttacagc  tcctcatcg  120
gtgatttca  gatctcctt  ttcgtgtcc  ggttaccag  aagggcaaa  gcataggcc  180
acagcgcct  agtgtagac  tggctgcca  cagctcctc  ccttgctga  ttccaggct  240
tgtccaggc  aaagagggc  ttgcggaca  caggatgag  gacaggaag  gacatctcc  300
ggagagcta  ggtgatgta  gcagacaag  tgacttcat  ttctactcc  cccttcatg  360
cattgttga  cagtgaccc  gagctcctg  aacaaccat  gtccttctg  tgctgagag  420
gccataaga  ggcttgggt  atgtgtact  catcgatga  gatatattt  cgagcctga  480
caaaactct  cagt  494



<210> 6288
<211> 1472
<212> PRT
<213> Rattus norvegicus
<308> P06238
<400> 6288

Met Gly Lys His Arg Leu Arg Ser Leu Ala Leu Leu Pro Leu Leu Leu 
  1               5                  10                  15
Arg Leu Leu Leu Leu Leu Leu Pro Thr Asp Ala Ser Ala Pro Gln Lys 
             20                  25                  30
Pro Ile Tyr Met Val Met Val Pro Ser Leu Leu His Ala Gly Thr Pro 
         35                  40                  45
Glu Lys Ala Cys Phe Leu Phe Ser His Leu Asn Glu Thr Val Ala Val 
     50                  55                  60
Arg Val Ser Leu Glu Ser Val His Gly Asn Gln Ser Leu Phe Thr Asp 
 65                  70                  75                  80
Leu Val Val Asp Lys Asp Leu Phe His Cys Thr Ser Phe Thr Val Pro 
                 85                  90                  95
Gln Ser Ser Ser Asp Glu Leu Met Phe Phe Thr Val Gln Val Lys Gly 
             100                105                110
Ala Thr His Glu Phe Arg Arg Gln Ser Thr Val Leu Val Lys Lys Lys 
         115                120                125
Glu Ser Leu Val Phe Ala Gln Thr Asp Lys Pro Ile Tyr Lys Pro Gly 
     130                135                140
Gln Thr Val Arg Phe Arg Val Val Ser Leu Asp Glu Ser Phe His Pro 
 145                150                155                160
Leu Asn Glu Leu Ile Pro Leu Leu Tyr Ile Gln Asp Pro Lys Asn Asn 
                 165                170                175
Arg Ile Ala Gln Trp Gln Asn Phe Asn Leu Glu Gly Gly Leu Lys Gln 
             180                185                190
Leu Ser Phe Pro Leu Ser Ser Glu Pro Thr Gln Gly Ser Tyr Lys Val 
         195                200                205
Val Ile Arg Thr Glu Ser Gly Arg Thr Val Glu His Pro Phe Ser Val 
     210                215                220
Glu Glu Phe Val Leu Pro Lys Phe Glu Val Arg Val Thr Val Pro Glu 
 225                230                235                240
Thr Ile Thr Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Ile 
                 245                250                255
Tyr Thr Tyr Gly Lys Pro Val Pro Gly Arg Val Thr Val Asn Ile Cys 
             260                265                270
Arg Lys Tyr Ser Asn Pro Ser Asn Cys Phe Gly Glu Glu Ser Val Ala 
         275                280                285
Phe Cys Glu Lys Leu Ser Gln Gln Leu Asp Gly Arg Gly Cys Phe Ser 
     290                295                300
Gln Leu Val Lys Thr Lys Ser Phe Gln Leu Lys Arg Gln Glu Tyr Glu 
 305                310                315                320
Met Gln Leu Asp Val His Ala Lys Ile Gln Glu Glu Gly Thr Gly Val 
                 325                330                335
Glu Glu Thr Gly Lys Gly Leu Thr Lys Ile Thr Arg Thr Ile Thr Lys 
             340                345                350
Leu Ser Phe Val Asn Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe 
         355                360                365
Val Gly Gln Val Leu Leu Val Asp Gly Arg Gly Thr Pro Ile Pro Tyr 
     370                375                380
Glu Thr Ile Phe Ile Gly Ala Asp Glu Ala Asn Leu Tyr Ile Asn Thr 
 385                390                395                400
Thr Thr Asp Lys His Gly Leu Ala Arg Phe Ser Ile Asn Thr Asp Asp 
                 405                410                415
Ile Met Gly Thr Ser Leu Thr Val Arg Ala Lys Tyr Lys Asp Ser Asn 
             420                425                430
Ala Cys Tyr Gly Phe Arg Trp Leu Thr Glu Glu Asn Val Glu Ala Trp 
         435                440                445
His Thr Ala Tyr Ala Val Phe Ser Pro Ser Arg Ser Phe Leu His Leu 
     450                455                460
Glu Ser Leu Pro Asp Lys Leu Arg Cys Asp Gln Thr Leu Glu Val Gln 
 465                470                475                480
Ala His Tyr Ile Leu Asn Gly Glu Ala Met Gln Glu Leu Lys Glu Leu 
                 485                490                495
Val Phe Tyr Tyr Leu Met Met Ala Lys Gly Gly Ile Val Arg Ala Gly 
             500                505                510
Thr His Val Leu Pro Leu Lys Gln Gly Gln Met Arg Gly His Phe Ser 
         515                520                525
Ile Leu Ile Ser Met Glu Thr Asp Leu Ala Pro Val Ala Arg Leu Val 
     530                535                540
Leu Tyr Ala Ile Leu Pro Asn Gly Glu Val Val Gly Asp Thr Ala Lys 
 545                550                555                560
Tyr Glu Ile Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Val Phe Arg 
                 565                570                575
Pro Asn Ser Gly Leu Pro Ala Thr Arg Ala Leu Leu Ser Val Met Ala 
             580                585                590
Ser Pro Gln Ser Leu Cys Gly Leu Arg Ala Val Asp Gln Ser Val Leu 
         595                600                605
Leu Met Lys Pro Glu Thr Glu Leu Ser Ala Ser Leu Ile Tyr Asp Leu 
     610                615                620
Leu Pro Val Lys Asp Leu Thr Gly Phe Pro Gln Gly Ala Asp Gln Arg 
 625                630                635                640
Glu Glu Asp Thr Asn Gly Cys Val Lys Gln Asn Asp Thr Tyr Ile Asn 
                 645                650                655
Gly Ile Leu Tyr Ser Pro Val Gln Asn Thr Asn Glu Glu Asp Met Tyr 
             660                665                670
Gly Phe Leu Lys Asp Met Gly Leu Lys Val Phe Thr Asn Ser Asn Ile 
         675                680                685
Arg Lys Pro Lys Val Cys Glu Arg Leu Arg Asp Asn Lys Gly Ile Pro 
     690                695                700
Ala Ala Tyr His Leu Val Ser Gln Ser His Met Asp Ala Phe Leu Glu 
 705                710                715                720
Ser Ser Glu Ser Pro Thr Glu Thr Arg Arg Ser Tyr Phe Pro Glu Thr 
                 725                730                735
Trp Ile Trp Asp Leu Val Val Val Asp Ser Ala Gly Val Ala Glu Val 
             740                745                750
Glu Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly Ala Phe 
         755                760                765
Cys Leu Ser Asn Asp Thr Gly Leu Gly Leu Ser Pro Val Val Gln Phe 
     770                775                780
Gln Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr Ser Val 
 785                790                795                800
Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn Tyr Leu 
                 805                810                815
Pro Thr Cys Ile Arg Val Ala Val Gln Leu Glu Ala Ser Pro Asp Phe 
             820                825                830
Leu Ala Ala Pro Glu Glu Lys Glu Gln Arg Ser His Cys Ile Cys Met 
         835                840                845
Asn Gln Arg His Thr Ala Ser Trp Ala Val Ile Pro Lys Ser Leu Gly 
     850                855                860
Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Asn Ser Lys Glu Leu 
 865                870                875                880
Cys Gly Asn Glu Val Pro Val Val Pro Glu Gln Gly Lys Lys Asp Thr 
                 885                890                895
Ile Ile Lys Ser Leu Leu Val Glu Pro Glu Gly Leu Glu Asn Glu Val 
             900                905                910
Thr Phe Asn Ser Leu Leu Cys Pro Met Gly Ala Glu Val Ser Glu Leu 
         915                920                925
Ile Ala Leu Lys Leu Pro Ser Asp Val Val Glu Glu Ser Ala Arg Ala 
     930                935                940
Ser Val Thr Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln Asn Thr 
 945                950                955                960
Gln Asp Leu Leu Lys Met Pro Tyr Gly Cys Gly Glu Gln Asn Met Val 
                 965                970                975
Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu Thr Gln 
             980                985                990
Gln Leu Thr Gln Glu Ile Lys Thr Lys Ala Ile Ala Tyr Leu Asn Thr 
         995                1000                1005
Gly Tyr Gln Arg Gln Leu Asn Tyr Lys His Arg Asp Gly Ser Tyr Ser 
     1010                1015                1020
Ala Phe Gly Asp Lys Pro Gly Arg Asn His Ala Asn Thr Trp Leu Thr 
 1025                1030                1035                1040
Ala Phe Val Leu Lys Ser Phe Ala Gln Ala Arg Lys Tyr Ile Phe Ile 
                 1045                1050                1055
Asp Glu Val His Ile Thr Gln Ala Leu Leu Trp Leu Ser Gln Gln Gln 
             1060                1065                1070
Lys Asp Asn Gly Cys Phe Arg Ser Ser Gly Ser Leu Leu Asn Asn Ala 
         1075                1080                1085
Met Lys Gly Gly Val Glu Asp Glu Val Thr Leu Ser Ala Tyr Ile Thr 
     1090                1095                1100
Ile Ala Leu Leu Glu Met Ser Leu Pro Val Thr His Pro Val Val Arg 
 1105                1110                1115                1120
Asn Ala Leu Phe Cys Leu Asp Thr Ala Trp Lys Ser Ala Arg Gly Gly 
                 1125                1130                1135
Ala Gly Gly Ser His Val Tyr Thr Lys Ala Leu Leu Ala Tyr Ala Phe 
             1140                1145                1150
Ala Leu Ala Gly Asn Gln Asp Thr Lys Lys Glu Ile Leu Lys Ser Leu 
         1155                1160                1165
Asp Glu Glu Ala Val Lys Glu Glu Asp Ser Val His Trp Thr Arg Pro 
     1170                1175                1180
Gln Lys Pro Ser Val Ser Val Gly Leu Trp Tyr Gln Pro Gln Ala Thr 
 1185                1190                1195                1200
Ser Ala Glu Val Glu Met Thr Ala Tyr Val Leu Leu Ala Tyr Leu Thr 
                 1205                1210                1215
Thr Glu Pro Ala Pro Thr Gln Glu Asp Leu Thr Ala Ala Met Leu Ile 
             1220                1225                1230
Val Lys Trp Leu Thr Lys Gln Gln Asn Ser His Gly Gly Phe Ser Ser 
         1235                1240                1245
Thr Gln Asp Thr Val Val Ala Leu His Ala Leu Ser Lys Tyr Gly Ser 
     1250                1255                1260
Ala Thr Phe Thr Arg Ala Lys Lys Ala Ala Gln Val Thr Ile Arg Ser 
 1265                1270                1275                1280
Ser Gly Thr Phe Ser Thr Lys Phe Gln Val Asn Asn Asn Asn Gln Leu 
                 1285                1290                1295
Leu Leu Gln Arg Val Thr Leu Pro Thr Val Pro Gly Asp Tyr Thr Val 
             1300                1305                1310
Lys Val Thr Gly Glu Gly Cys Val Tyr Leu Gln Thr Ser Leu Lys Tyr 
         1315                1320                1325
Ser Val Leu Pro Arg Glu Glu Glu Phe Pro Phe Ala Val Val Val Gln 
     1330                1335                1340
Thr Leu Pro Gly Thr Cys Glu Asp Pro Lys Ala His Thr Ser Phe Gln 
 1345                1350                1355                1360
Ile Ser Leu Asn Ile Ser Tyr Thr Gly Ser Arg Ser Glu Ser Asn Met 
                 1365                1370                1375
Ala Ile Ala Asp Val Lys Met Val Ser Gly Phe Ile Pro Leu Lys Pro 
             1380                1385                1390
Thr Val Lys Met Leu Glu Arg Ser Val His Val Ser Arg Thr Glu Val 
         1395                1400                1405
Ser Asn Asn His Val Leu Ile Tyr Leu Asp Lys Val Ser Asn Gln Thr 
     1410                1415                1420
Val Asn Leu Ser Phe Thr Val Gln Gln Asp Ile Pro Ile Arg Asp Leu 
 1425                1430                1435                1440
Lys Pro Ala Val Val Lys Val Tyr Asp Tyr Tyr Glu Lys Asp Glu Phe 
                 1445                1450                1455
Ala Val Ala Lys Tyr Ser Ala Pro Cys Ser Thr Asp Tyr Gly Asn Ala 
             1460                1465                1470



<210> 6289
<211> 4576
<212> DNA
<213> Homo sapiens
<308> XM_006925
<400> 6289

tacaataca  tctgttctc  tccagctcc  tctttctgc  acatgggga  gaacaaact  60
cttcatcca  gtctggttc  tctcctctt  gtcctcctg  ccacagacg  ctcagtctc  120
ggaaaaccg  agtatatgg  tctggtccc  tccctgctc  acactgaga  cactgagaa  180
ggctgtgtc  ttctgagct  cctgaatga  acagtgact  taagtgctt  cttggagtc  240
gtcagggga  acaggagcc  cttcactga  ctggaggcg  agaatgacg  actccactg  300
gtcgccttc  ctgtcccaa  gtcttcatc  aatgaggag  taatgttcc  cactgtcca  360
gtgaaagga  caacccaag  atttaagaa  cggaccaca  tgatggtta  gaacgagga  420
agtctggtc  ttgtccaga  agacaaatc  atctacaaa  cagggcaga  agtgaaatt  480
cgtgttgtc  ccatggatg  aaactttca  cccctgaat  agttgattc  actagtata  540
attcaggat  ccaaaggaa  tcgcatcgc  caatggcag  gtttccagt  agagggtgg  600
ctcaagcaa  tttcttttc  cctctcatc  gagcccttc  agggctcct  caaggtggt  660
gtacagaag  aatcaggtg  aaggacaga  caccctttc  ccgtggagg  atttgttct  720
cccaagttt  aagtacaag  aacagtgcc  aagataatc  ccatcttgg  agaagagat  780
aatgtatca  tgtgtggcc  atacacata  gggaagcct  tccctggac  tgtgactgt  840
agcatttgc  gaaagtata  tgacgcttc  gactgccac  gtgaagatt  acaggcttt  900
tgtgagaaa  tcagtggac  gctaaacag  catggctgc  tctatcagc  agtaaaaac  960
aaggtcttc  agctgaaga  gaaggagta  gaaatgaaa  ttcacactg  ggcccagat  1020
caagaagaa  gaacagtgg  ggaattgac  ggaaggcag  ccagtgaaa  cacaagaac  1080
ataaccaaa  tctcatttg  gaaagtgga  tcacacttt  gacagggaa  tcccttctt  1140
gggcaggtg  gcctagtag  tgggaaagg  gtccctata  caaataaag  catattcat  1200
agaggaaat  aagcaaact  ttactccaa  gctaccacg  atgagcatg  ccttgtaca  1260
ttctctatc  acaccacca  tgttatggg  acctctctt  ctgttaggg  caattacaa  1320
gatcgtagt  cctgttacg  ctaccagtg  gtgtcagaa  aacacgaag  ggcacatca  1380
actgcttat  ttgtgttct  cccaagcaa  agctttgtc  accttgagc  catgtctca  1440
gaactaccc  gtggccata  tcagacagt  caggcacat  atattctga  tggaggcac  1500
ctgctgggg  tgaagaagc  ctccttcta  tatctgata  tggcaaagg  aggcattgt  1560
cgaactggg  ctcatggac  gcttgtgaa  caggaagac  tgaagggcc  tttttccat  1620
tcaatccct  tgaagtcag  cattgctcc  gtcgctcgg  tgctcatct  tgctgtttt  1680
cctaccggg  acgtgattg  ggattctgc  aaatatgat  ttgaaaatt  tctggccaa  1740
aaggtggat  tgagcttca  cccatcaca  agtctccca  cctcacacg  ccacctgcg  1800
gtcacagcg  ctcctcagt  cgtctgcgc  ctccgtgct  tggaccaaa  cgtgctgct  1860
atgaagcct  atgctgagc  ctcggcgtc  tcggtttac  acctgctac  agaaaagga  1920
ctcactggc  tccctgggc  tttgaatga  caggacaat  aagactgca  caatcgtca  1980
aatgtctat  ttaatggaa  cacatatac  ccagtatca  gtacaaatg  aaaggatat  2040
tacagcttc  tagaggaca  gggcttaaa  gcattcacc  actcaaaga  tcgtaaacc  2100
aaaatgtgt  cacagcttc  acagtatga  atgcatgga  ctgaaggtc  acgtgtagg  2160
ttttatgag  cagatgtaa  gggaagagg  catgcacgc  tggtgcatg  tgaagagcc  2220
cacacggag  ccgtacgaa  gtacttccc  gagacatgg  tctgggatt  ggtggtggt  2280
aactcagca  gtgtggctg  ggtaggagt  acagtccct  acaccatca  cgagtggaa  2340
gcaggggcc  tctgcctgt  tgaagatgc  ggacttggt  tctcttcca  tgcctctct  2400
cgagccttc  agcccttct  tgtggagct  acaatgcct  actctgtga  tcgtggaga  2460
gccttcaca  tcaaggcca  ggtcctaaa  taccttccc  aatgcatcc  ggtcagtgt  2520
cagctggaa  cctctcccg  cttcctagc  gtcccagtg  agaaggaac  agcgcctca  2580
tgcatctgt  caaacgggc  gcaaactgt  tcctgggca  taaccccaa  gtcattagg  2640
aatgtgaat  tcactgtga  cgcagaggc  ctagagtct  aagagctgt  tgggactga  2700
gtgccttca  ttcctgaac  cggaaggaa  gacacagtc  tcaagcctc  gttggttga  2760
cctgaagga  tagagaagg  aacaacatt  aactcccta  tttgtccat  aggtggtga  2820
gtttctgaa  aattatccc  gaaactgcc  ccaaatgtg  tagaagaat  tgcccgagc  2880
tctgtctca  ttttgggag  catattagg  tctgccatg  aaaacacac  aaatcttct  2940
cagatgccc  atggctgtg  agagcagaa  atggtcctc  ttgctccta  catctatgt  3000
ctggattat  taaatgaaa  acagcagct  actccagag  tcaagtcca  ggccattgg  3060
tatctcaac  ctggttacc  gagacagtt  aactacaaa  actatgatg  ctcctacag  3120
acctttggg  agcgatatg  caggaacca  ggcaacacc  ggctcacag  ctttgttct  3180
aagactttt  cccaagctc  agcctacat  ttcatcgat  aagcacaca  tacccaagc  3240
ctcatatgg  tctcccaga  gcagaagga  aatggctgt  tcaggagct  tgggtcact  3300
ctcaacaat  ccataaagg  aggagtaga  gatgaagtg  ccctctccg  ctatatcac  3360
atcgccctt  tggagattc  tctcacagt  actcaccct  ttgtccgca  tgccctgtt  3420
tgcctggag  cagcctgga  gacagcaca  gaaggggac  atggcagcc  tgtatatac  3480
aaagcactg  tggcctatg  ttttgccct  gcaggtaac  aggacaaga  gaaggaagt  3540
ctcaagtca  ttaatgagg  agctgtgaa  aaagacaac  ctgtccatt  ggagcgccc  3600
cagaaaccc  aggcaccag  ggggcattt  tacgaaccc  aggctccct  tgctgaggt  3660
gagatgaca  cctatgtgc  cctcgctta  ctcacggcc  agccagccc  aacctcgga  3720
gacctgacc  ctgcaacca  catcgtgaa  tggatcacg  agcagcaga  tgcccaggg  3780
ggtttctcc  ccacccagg  cacagtggt  gctctccat  ctctgtcca  atatggagc  3840
gccacattt  ccaggactg  gaaggctgc  caggtgact  tccagtctt  agggacatt  3900
tccagcaaa  tccaagtgg  caacaacaa  cgcctgtta  tgcagcagg  ctcattgcc  3960
gagctgcct  gggaataca  catgaaagt  acaggagaa  gatgtgtct  cctccagac  4020
tccttgaaa  acaatattc  cccagaaaa  gaagagttc  cctttgctt  aggagtgca  4080
actctgcct  aaacttgtg  tgaacccaa  gcccacacc  gcttccaaa  ctccctaag  4140
gtcagttac  cagggagcc  ctctgcctc  aacatggcg  tcgttgatg  gaagatggt  4200
tctggcttc  ttcccctga  gccaacagt  aaaatgctt  aaagatcta  ccatgtgag  4260
cggacagaa  tcagcagca  ccatgtctt  atttacctt  ataaggtgt  aaatcagac  4320
ctgagcttg  tcttcacgg  tctgcaaga  gtcccagta  gagatctga  accagccat  4380
gtgaaagtc  atgattact  cgagacgga  gagtttgca  ttgctgagt  caatgctcc  4440
tgcagcaaa  atcttggaa  tgcttgaag  ccacaaggc  gaaaagtgc  ttgctggag  4500
cctgttctc  gagctccac  gaagacacg  gtttttgta  ctttaaaga  ttgatgaat  4560
aacactttt  ctggtc  4576



<210> 6290
<211> 1474
<212> PRT
<213> Homo sapiens
<308> XP_006925
<400> 6290

Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
  1               5                  10                  15
Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
             20                  25                  30
Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys 
         35                  40                  45
Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu 
     50                  55                  60
Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu 
 65                  70                  75                  80
Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                 85                  90                  95
Asn Glu Glu Val Met Phe Leu Thr Val Gln Val Lys Gly Pro Thr Gln 
             100                105                110
Glu Phe Lys Lys Arg Thr Thr Val Met Val Lys Asn Glu Asp Ser Leu 
         115                120                125
Val Phe Val Gln Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val 
     130                135                140
Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
 145                150                155                160
Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala 
                 165                170                175
Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe Ser Phe 
             180                185                190
Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys Val Val Val Gln 
         195                200                205
Lys Lys Ser Gly Gly Arg Thr Glu His Pro Phe Thr Val Glu Glu Phe 
     210                215                220
Val Leu Pro Lys Phe Glu Val Gln Val Thr Val Pro Lys Ile Ile Thr 
 225                230                235                240
Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Leu Tyr Thr Tyr 
                 245                250                255
Gly Lys Pro Val Pro Gly His Val Thr Val Ser Ile Cys Arg Lys Tyr 
             260                265                270
Ser Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu 
         275                280                285
Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val 
     290                295                300
Lys Thr Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met Lys Leu 
 305                310                315                320
His Thr Glu Ala Gln Ile Gln Glu Glu Gly Thr Val Val Glu Leu Thr 
                 325                330                335
Gly Arg Gln Ser Ser Glu Ile Thr Arg Thr Ile Thr Lys Leu Ser Phe 
             340                345                350
Val Lys Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe Phe Gly Gln 
         355                360                365
Val Arg Leu Val Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile 
     370                375                380
Phe Ile Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp 
 385                390                395                400
Glu His Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly 
                 405                410                415
Thr Ser Leu Thr Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys Tyr 
             420                425                430
Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His His Thr Ala 
         435                440                445
Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val His Leu Glu Pro Met 
     450                455                460
Ser His Glu Leu Pro Cys Gly His Thr Gln Thr Val Gln Ala His Tyr 
 465                470                475                480
Ile Leu Asn Gly Gly Thr Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr 
                 485                490                495
Tyr Leu Ile Met Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly 
             500                505                510
Leu Leu Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile 
         515                520                525
Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala 
     530                535                540
Val Leu Pro Thr Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp Val 
 545                550                555                560
Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ser Gln 
                 565                570                575
Ser Leu Pro Ala Ser His Ala His Leu Arg Val Thr Ala Ala Pro Gln 
             580                585                590
Ser Val Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys 
         595                600                605
Pro Asp Ala Glu Leu Ser Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu 
     610                615                620
Lys Asp Leu Thr Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asn Glu 
 625                630                635                640
Asp Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Thr Tyr Thr 
                 645                650                655
Pro Val Ser Ser Thr Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp 
             660                665                670
Met Gly Leu Lys Ala Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Met 
         675                680                685
Cys Pro Gln Leu Gln Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg 
     690                695                700
Val Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His Ala Arg Leu 
 705                710                715                720
Val His Val Glu Glu Pro His Thr Glu Thr Val Arg Lys Tyr Phe Pro 
                 725                730                735
Glu Thr Trp Ile Trp Asp Leu Val Val Val Asn Ser Ala Gly Val Ala 
             740                745                750
Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly 
         755                760                765
Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala 
     770                775                780
Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr 
 785                790                795                800
Ser Val Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn 
                 805                810                815
Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln Leu Glu Ala Ser Pro 
             820                825                830
Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys Ile 
         835                840                845
Cys Ala Asn Gly Arg Gln Thr Val Ser Trp Ala Val Thr Pro Lys Ser 
     850                855                860
Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu Ser Gln 
 865                870                875                880
Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg Lys 
                 885                890                895
Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys 
             900                905                910
Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val Ser 
         915                920                925
Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser Ala 
     930                935                940
Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln 
 945                950                955                960
Asn Thr Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln Asn 
                 965                970                975
Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu 
             980                985                990
Thr Gln Gln Leu Thr Pro Glu Ile Lys Ser Lys Ala Ile Gly Tyr Leu 
         995                1000                1005
Asn Thr Gly Tyr Gln Arg Gln Leu Asn Tyr Lys His Tyr Asp Gly Ser 
     1010                1015                1020
Tyr Ser Thr Phe Gly Glu Arg Tyr Gly Arg Asn Gln Gly Asn Thr Trp 
 1025                1030                1035                1040
Leu Thr Ala Phe Val Leu Lys Thr Phe Ala Gln Ala Arg Ala Tyr Ile 
                 1045                1050                1055
Phe Ile Asp Glu Ala His Ile Thr Gln Ala Leu Ile Trp Leu Ser Gln 
             1060                1065                1070
Arg Gln Lys Asp Asn Gly Cys Phe Arg Ser Ser Gly Ser Leu Leu Asn 
         1075                1080                1085
Asn Ala Ile Lys Gly Gly Val Glu Asp Glu Val Thr Leu Ser Ala Tyr 
     1090                1095                1100
Ile Thr Ile Ala Leu Leu Glu Ile Pro Leu Thr Val Thr His Pro Val 
 1105                1110                1115                1120
Val Arg Asn Ala Leu Phe Cys Leu Glu Ser Ala Trp Lys Thr Ala Gln 
                 1125                1130                1135
Glu Gly Asp His Gly Ser His Val Tyr Thr Lys Ala Leu Leu Ala Tyr 
             1140                1145                1150
Ala Phe Ala Leu Ala Gly Asn Gln Asp Lys Arg Lys Glu Val Leu Lys 
         1155                1160                1165
Ser Leu Asn Glu Glu Ala Val Lys Lys Asp Asn Ser Val His Trp Glu 
     1170                1175                1180
Arg Pro Gln Lys Pro Lys Ala Pro Val Gly His Phe Tyr Glu Pro Gln 
 1185                1190                1195                1200
Ala Pro Ser Ala Glu Val Glu Met Thr Ser Tyr Val Leu Leu Ala Tyr 
                 1205                1210                1215
Leu Thr Ala Gln Pro Ala Pro Thr Ser Glu Asp Leu Thr Ser Ala Thr 
             1220                1225                1230
Asn Ile Val Lys Trp Ile Thr Lys Gln Gln Asn Ala Gln Gly Gly Phe 
         1235                1240                1245
Ser Ser Thr Gln Asp Thr Val Val Ala Leu His Ala Leu Ser Lys Tyr 
     1250                1255                1260
Gly Ala Ala Thr Phe Thr Arg Thr Gly Lys Ala Ala Gln Val Thr Ile 
 1265                1270                1275                1280
Gln Ser Ser Gly Thr Phe Ser Ser Lys Phe Gln Val Asp Asn Asn Asn 
                 1285                1290                1295
Arg Leu Leu Leu Gln Gln Val Ser Leu Pro Glu Leu Pro Gly Glu Tyr 
             1300                1305                1310
Ser Met Lys Val Thr Gly Glu Gly Cys Val Tyr Leu Gln Thr Ser Leu 
         1315                1320                1325
Lys Tyr Asn Ile Leu Pro Glu Lys Glu Glu Phe Pro Phe Ala Leu Gly 
     1330                1335                1340
Val Gln Thr Leu Pro Gln Thr Cys Asp Glu Pro Lys Ala His Thr Ser 
 1345                1350                1355                1360
Phe Gln Ile Ser Leu Ser Val Ser Tyr Thr Gly Ser Arg Ser Ala Ser 
                 1365                1370                1375
Asn Met Ala Ile Val Asp Val Lys Met Val Ser Gly Phe Ile Pro Leu 
             1380                1385                1390
Lys Pro Thr Val Lys Met Leu Glu Arg Ser Asn His Val Ser Arg Thr 
         1395                1400                1405
Glu Val Ser Ser Asn His Val Leu Ile Tyr Leu Asp Lys Val Ser Asn 
     1410                1415                1420
Gln Thr Leu Ser Leu Phe Phe Thr Val Leu Gln Asp Val Pro Val Arg 
 1425                1430                1435                1440
Asp Leu Lys Pro Ala Ile Val Lys Val Tyr Asp Tyr Tyr Glu Thr Asp 
                 1445                1450                1455
Glu Phe Ala Ile Ala Glu Tyr Asn Ala Pro Cys Ser Lys Asp Leu Gly 
             1460                1465                1470
Asn Ala 
         1475



<210> 6291
<211> 503
<212> DNA
<213> Rattus norvegicus
<308> AA900848
<400> 6291

cggccgcaa  ggtcgcaac  gaggccttg  acatggggg  ggcatgggc  ctgcccagt  60
cttgggtca  aatggcaca  gtctgtaga  gggcaccgc  ggggatctg  gcccagaag  120
ttgcaggta  agcggtgac  gctctgtcg  gcagcttgc  catggaagc  aggcttgca  180
tggccacag  ggggcccct  cgtgtggtg  aaacagcgc  agcattgcc  cgtgtgggg  240
tcacaggca  cgggatccg  ggggtcaat  ttcccactg  actcacaca  ttggcacct  300
ccatctggc  tggattggt  cccaaagtg  ccgtgggca  aatcctcac  ccgaagccc  360
gtgtagcct  ctcgacagt  gcacacaat  tgctgggaa  atccatccc  gtgacatga  420
gtaccaaag  gtcgctggc  cccggggcc  tccgttcag  caacgccct  acagtttgg  480
actggtcac  tacttgttc  cgt  503



<210> 6292
<211> 1801
<212> PRT
<213> Rattus norvegicus
<308> P15800
<400> 6292

Met Glu Trp Ala Ser Gly Lys Pro Gly Arg Gly Arg Gln Gly Gln Pro 
  1               5                  10                  15
Val Pro Trp Glu Leu Arg Leu Gly Leu Leu Leu Ser Val Leu Ala Ala 
             20                  25                  30
Thr Leu Ala Gln Val Pro Ser Leu Asp Val Pro Gly Cys Ser Arg Gly 
         35                  40                  45
Ser Cys Tyr Pro Ala Thr Gly Asp Leu Leu Val Gly Arg Ala Asp Arg 
     50                  55                  60
Leu Thr Ala Ser Ser Thr Cys Gly Leu His Ser Pro Gln Pro Tyr Cys 
 65                  70                  75                  80
Ile Val Ser His Leu Gln Asp Glu Lys Lys Cys Phe Leu Cys Asp Ser 
                 85                  90                  95
Arg Arg Pro Phe Ser Ala Arg Asp Asn Pro Asn Ser His Arg Ile Gln 
             100                105                110
Asn Val Val Thr Ser Phe Ala Pro Gln Arg Arg Thr Ala Trp Trp Gln 
         115                120                125
Ser Glu Asn Gly Val Pro Met Val Thr Ile Gln Leu Asp Leu Glu Ala 
     130                135                140
Glu Phe His Phe Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg Pro 
 145                150                155                160
Ala Ala Met Leu Val Glu Arg Ser Ala Asp Phe Gly Arg Thr Trp Arg 
                 165                170                175
Val Tyr Arg Tyr Phe Ser Tyr Asp Cys Gly Ala Asp Phe Pro Gly Ile 
             180                185                190
Pro Leu Ala Pro Pro Arg Arg Trp Asp Asp Val Val Cys Glu Ser Arg 
         195                200                205
Tyr Ser Glu Ile Glu Pro Ser Thr Glu Gly Glu Val Ile Tyr Arg Val 
     210                215                220
Leu Asp Pro Ala Ile Pro Ile Pro Asp Pro Tyr Ser Ser Arg Ile Gln 
 225                230                235                240
Asn Leu Leu Lys Ile Thr Asn Leu Arg Val Asn Leu Thr Arg Leu His 
                 245                250                255
Thr Leu Gly Asp Asn Leu Leu Asp Pro Arg Arg Glu Ile Arg Glu Lys 
             260                265                270
Tyr Tyr Tyr Ala Leu Tyr Glu Leu Val Ile Arg Gly Asn Cys Phe Cys 
         275                280                285
Tyr Gly His Ala Ser Gln Cys Ala Pro Ala Pro Gly Ala Pro Ala His 
     290                295                300
Ala Glu Gly Met Val His Gly Ala Cys Ile Cys Lys His Asn Thr Arg 
 305                310                315                320
Gly Leu Asn Cys Glu Gln Cys Gln Asp Phe Tyr Gln Asp Leu Pro Trp 
                 325                330                335
His Pro Ala Glu Asp Gly His Thr His Ala Cys Arg Lys Cys Glu Cys 
             340                345                350
Asn Gly His Ser His Ser Cys His Phe Asp Met Ala Val Tyr Leu Ala 
         355                360                365
Ser Gly Asn Val Ser Gly Gly Val Cys Asp Gly Cys Gln His Asn Thr 
     370                375                380
Ala Gly Arg His Cys Glu Leu Cys Arg Pro Phe Phe Tyr Arg Asp Pro 
 385                390                395                400
Thr Lys Asp Met Arg Asp Pro Ala Ala Cys Arg Pro Cys Asp Cys Asp 
                 405                410                415
Pro Met Gly Ser Gln Asp Gly Gly Arg Cys Asp Ser His Asp Asp Pro 
             420                425                430
Val Leu Gly Leu Val Ser Gly Gln Cys Arg Cys Lys Glu His Val Val 
         435                440                445
Gly Thr Arg Cys Gln Gln Cys Arg Asp Gly Phe Phe Gly Leu Ser Ala 
     450                455                460
Ser Asn Pro Arg Gly Cys Gln Arg Cys Gln Cys Asn Ser Arg Gly Thr 
 465                470                475                480
Val Pro Gly Gly Thr Pro Cys Asp Ser Ser Ser Gly Thr Cys Phe Cys 
                 485                490                495
Lys Arg Leu Val Thr Gly Asp Gly Cys Asp Arg Cys Leu Pro Gly His 
             500                505                510
Trp Gly Leu Ser His Asp Leu Leu Gly Cys Arg Pro Cys Asp Cys Asp 
         515                520                525
Val Gly Gly Ala Leu Asp Pro Gln Cys Asp Glu Ala Thr Gly Gln Cys 
     530                535                540
Pro Cys Arg Pro His Met Ile Gly Arg Arg Cys Glu Gln Val Gln Pro 
 545                550                555                560
Gly Tyr Phe Arg Pro Phe Leu Asp His Leu Thr Trp Glu Ala Glu Gly 
                 565                570                575
Ala His Gly Gln Val Leu Glu Val Val Glu Arg Leu Val Thr Asn Arg 
             580                585                590
Glu Thr Pro Ser Trp Thr Gly Val Gly Phe Val Arg Leu Arg Glu Gly 
         595                600                605
Gln Glu Val Glu Phe Leu Val Thr Ser Leu Pro Arg Ala Met Asp Tyr 
     610                615                620
Asp Leu Leu Leu Arg Trp Glu Pro Gln Val Pro Glu Gln Trp Ala Glu 
 625                630                635                640
Leu Glu Leu Val Val Gln Arg Pro Gly Pro Val Ser Ala His Ser Pro 
                 645                650                655
Cys Gly His Val Leu Pro Arg Asp Asp Arg Ile Gln Gly Met Leu His 
             660                665                670
Pro Asn Thr Arg Val Leu Val Phe Pro Arg Pro Val Cys Leu Glu Pro 
         675                680                685
Gly Leu Ser Tyr Lys Leu Lys Leu Lys Leu Thr Gly Thr Gly Gly Arg 
     690                695                700
Ala His Pro Glu Thr Pro Tyr Ser Gly Ser Gly Ile Leu Ile Asp Ser 
 705                710                715                720
Leu Val Leu Gln Pro His Val Leu Met Leu Glu Met Phe Ser Gly Gly 
                 725                730                735
Asp Ala Ala Ala Leu Glu Arg Arg Thr Thr Phe Glu Arg Tyr Arg Cys 
             740                745                750
His Glu Glu Gly Leu Met Pro Ser Lys Thr Pro Leu Ser Glu Ala Cys 
         755                760                765
Val Pro Leu Leu Ile Ser Ala Ser Ser Leu Val Tyr Asn Gly Ala Leu 
     770                775                780
Pro Cys Gln Cys Asp Pro Gln Gly Ser Leu Ser Ser Glu Cys Asn Pro 
 785                790                795                800
His Gly Gly Gln Cys Arg Cys Lys Pro Gly Val Val Gly Arg Arg Cys 
                 805                810                815
Asp Ala Cys Ala Thr Gly Tyr Tyr Gly Phe Gly Pro Ala Gly Cys Gln 
             820                825                830
Ala Cys Gln Cys Ser Pro Asp Gly Ala Leu Ser Ala Leu Cys Glu Gly 
         835                840                845
Thr Ser Gly Gln Cys Leu Cys Arg Thr Gly Ala Phe Gly Leu Arg Cys 
     850                855                860
Asp His Cys Gln Arg Gly Gln Trp Gly Phe Pro Asn Cys Arg Pro Cys 
 865                870                875                880
Val Cys Asn Gly Arg Ala Asp Glu Cys Asp Ala His Thr Gly Ala Cys 
                 885                890                895
Leu Gly Cys Arg Asp Tyr Thr Gly Gly Glu His Cys Glu Arg Cys Ile 
             900                905                910
Ala Gly Phe His Gly Asp Pro Arg Leu Pro Tyr Gly Gly Gln Cys Arg 
         915                920                925
Pro Cys Pro Cys Pro Glu Gly Pro Gly Ser Gln Arg His Phe Ala Thr 
     930                935                940
Ser Cys His Arg Asp Gly Tyr Ser Gln Gln Ile Val Cys His Cys Arg 
 945                950                955                960
Ala Gly Tyr Thr Gly Leu Arg Cys Glu Ala Cys Ala Pro Gly His Phe 
                 965                970                975
Gly Asp Pro Ser Lys Pro Gly Gly Arg Cys Gln Leu Cys Glu Cys Ser 
             980                985                990
Gly Asn Ile Asp Pro Thr Asp Pro Gly Ala Cys Asp Pro His Thr Gly 
         995                1000                1005
Gln Cys Leu Arg Cys Leu His His Thr Glu Gly Pro His Cys Gly His 
     1010                1015                1020
Cys Lys Pro Gly Phe His Gly Gln Ala Ala Arg Gln Ser Cys His Arg 
 1025                1030                1035                1040
Cys Thr Cys Asn Leu Leu Gly Thr Asp Pro Gln Arg Cys Pro Ser Thr 
                 1045                1050                1055
Asp Leu Cys His Cys Asp Pro Ser Thr Gly Gln Cys Pro Cys Leu Pro 
             1060                1065                1070
His Val Gln Gly Leu Ser Cys Asp Arg Cys Ala Pro Asn Phe Trp Asn 
         1075                1080                1085
Phe Thr Ser Gly Arg Gly Cys Gln Pro Cys Ala Cys His Pro Ser Arg 
     1090                1095                1100
Ala Arg Gly Pro Thr Cys Asn Glu Phe Thr Gly Gln Cys His Cys His 
 1105                1110                1115                1120
Ala Gly Phe Gly Gly Arg Thr Cys Ser Glu Cys Gln Glu Leu His Trp 
                 1125                1130                1135
Gly Asp Pro Gly Leu Gln Cys Arg Ala Cys Asp Cys Asp Pro Arg Gly 
             1140                1145                1150
Ile Asp Lys Pro Gln Cys His Arg Ser Thr Gly His Cys Ser Cys Arg 
         1155                1160                1165
Pro Gly Val Ser Gly Val Arg Cys Asp Gln Cys Ala Arg Gly Phe Ser 
     1170                1175                1180
Gly Val Phe Pro Ala Cys His Pro Cys His Ala Cys Phe Gly Asp Trp 
 1185                1190                1195                1200
Asp Arg Val Val Gln Asp Leu Ala Ala Arg Thr Arg Arg Leu Glu Gln 
                 1205                1210                1215
Trp Ala Gln Glu Leu Gln Gln Thr Gly Val Leu Gly Ala Phe Glu Ser 
             1220                1225                1230
Ser Phe Leu Asn Leu Gln Gly Lys Leu Gly Met Val Gln Ala Ile Val 
         1235                1240                1245
Ala Ala Arg Asn Thr Ser Ala Ala Ser Thr Ala Lys Leu Val Glu Ala 
     1250                1255                1260
Thr Glu Gly Leu Arg His Glu Ile Gly Lys Thr Thr Glu Arg Leu Thr 
 1265                1270                1275                1280
Gln Leu Glu Ala Glu Leu Thr Asp Val Gln Asp Glu Asn Phe Asn Ala 
                 1285                1290                1295
Asn His Ala Leu Ser Gly Leu Glu Arg Asp Gly Leu Ala Leu Asn Leu 
             1300                1305                1310
Thr Leu Arg Gln Leu Asp Gln His Leu Asp Ile Leu Lys His Ser Asn 
         1315                1320                1325
Phe Leu Gly Ala Tyr Asp Ser Ile Arg His Ala His Ser Gln Ser Thr 
     1330                1335                1340
Glu Ala Glu Arg Arg Ala Asn Ala Ser Thr Phe Ala Ile Pro Ser Pro 
 1345                1350                1355                1360
Val Ser Asn Ser Ala Asp Thr Arg Arg Arg Ala Glu Val Leu Met Gly 
                 1365                1370                1375
Ala Gln Arg Glu Asn Phe Asn Arg Gln His Leu Ala Asn Gln Gln Ala 
             1380                1385                1390
Leu Gly Arg Leu Ser Thr His Thr His Thr Leu Ser Leu Thr Gly Val 
         1395                1400                1405
Asn Glu Leu Val Cys Gly Ala Pro Gly Asp Ala Pro Cys Ala Thr Ser 
     1410                1415                1420
Pro Cys Gly Gly Ala Gly Cys Arg Asp Glu Asp Gly Gln Pro Arg Cys 
 1425                1430                1435                1440
Gly Gly Leu Gly Cys Ser Gly Ala Ala Ala Thr Ala Asp Leu Ala Leu 
                 1445                1450                1455
Gly Arg Ala Arg His Thr Gln Ala Glu Leu Gln Arg Ala Leu Val Glu 
             1460                1465                1470
Gly Gly Gly Ile Leu Ser Arg Val Ser Glu Thr Arg Arg Gln Ala Glu 
         1475                1480                1485
Glu Ala Gln Gln Arg Ala Gln Ala Ala Leu Asp Lys Ala Asn Ala Ser 
     1490                1495                1500
Arg Gly Gln Val Glu Gln Ala Asn Gln Glu Leu Arg Glu Leu Ile Gln 
 1505                1510                1515                1520
Asn Val Lys Asp Phe Leu Ser Gln Glu Gly Ala Asp Pro Asp Ser Ile 
                 1525                1530                1535
Glu Met Val Ala Thr Arg Val Leu Asp Ile Ser Ile Pro Ala Ser Pro 
             1540                1545                1550
Glu Gln Ile Gln Arg Leu Ala Ser Glu Ile Ala Glu Arg Val Arg Ser 
         1555                1560                1565
Leu Ala Asp Val Asp Thr Ile Leu Ala His Thr Met Gly Asp Val Arg 
     1570                1575                1580
Arg Ala Glu Gln Leu Leu Gln Asp Ala Gln Arg Ala Arg Ser Arg Ala 
 1585                1590                1595                1600
Glu Gly Glu Arg Gln Lys Ala Glu Thr Val Gln Ala Ala Leu Glu Glu 
                 1605                1610                1615
Ala Gln Arg Ala Gln Gly Ala Ala Gln Gly Ala Ile Arg Gly Ala Val 
             1620                1625                1630
Val Asp Thr Lys Asn Thr Glu Gln Thr Leu Gln Gln Val Gln Glu Arg 
         1635                1640                1645
Met Ala Gly Thr Glu Gln Ser Leu Asn Ser Ala Ser Glu Arg Ala Arg 
     1650                1655                1660
Gln Leu His Ala Leu Leu Glu Ala Leu Lys Leu Lys Arg Ala Gly Asn 
 1665                1670                1675                1680
Ser Leu Ala Ala Ser Thr Ala Glu Glu Thr Ala Gly Ser Ala Gln Ser 
                 1685                1690                1695
Arg Ala Arg Glu Ala Glu Lys Gln Leu Arg Glu Gln Val Gly Asp Gln 
             1700                1705                1710
Tyr Gln Thr Val Arg Ala Leu Ala Glu Arg Lys Ala Glu Gly Val Leu 
         1715                1720                1725
Ala Ala Gln Ala Arg Ala Glu Gln Leu Arg Asp Glu Ala Arg Gly Leu 
     1730                1735                1740
Leu Gln Ala Ala Gln Asp Lys Leu Gln Arg Leu Gln Glu Leu Glu Gly 
 1745                1750                1755                1760
Thr Tyr Glu Glu Asn Glu Arg Glu Leu Glu Val Lys Ala Ala Gln Leu 
                 1765                1770                1775
Asp Gly Leu Glu Ala Arg Met Arg Ser Val Leu Gln Ala Ile Asn Leu 
             1780                1785                1790
Gln Val Gln Ile Tyr Asn Thr Cys Gln 
         1795                1800



<210> 6293
<211> 5683
<212> DNA
<213> Homo sapiens
<308> X79683
<400> 6293

ccgcccggt  ttgcgctcc  tcccagaat  cgctccggc  tttccttcc  gccgcgatt  60
ccaactttg  tcaaagtcg  cggactcta  gctgtcgga  ggaccgctg  acagacctg  120
gaactgaca  agggcctgg  gggaaatag  ccaaagacc  acaggatgg  gctgacctc  180
accgaaaga  ggaggggac  gcctctgcc  tgggaactt  gactgcccc  actgctaag  240
gtgctggct  ccacactgg  acaggcccc  gccccggat  tccctggct  ttccagggg  300
agctgctac  ccgccacgg  cgacctgct  gtgggccga  ctgacagac  gactgcctc  360
tccacttgt  gcctgaatg  ccgccagcc  tactgcatc  tcagtcacc  gcaggacga  420
aagaagtgc  tcctttgtg  ctcccggcg  cccttctct  ctagagaca  cccacacac  480
catcgcatc  agaatgtag  caccagctt  gcaccacag  ggcgggcag  ttggtggca  540
tcacagaat  gtatccctg  ggtcaccat  cagctggac  tggaggctg  gtttcattt  600
acacacctc  ttatgacct  caagacatt  cgccctgct  ccatgctgg  cgaacgctc  660
gcagacttt  gccgcacct  gcatgtgta  cgatatttc  cctatcact  tggggctga  720
ttcccagga  tcccactag  acccccacg  cactgggat  atgtagtct  tgagtcccg  780
tactcagag  ttgagccat  cactgaagg  gaggtcatc  atcgtgtgc  ggaccctgc  840
atccctatc  cagacccct  cagctcacg  attcagaac  tgttgaaga  caccaacct  900
cgggtgaac  tgactcgtc  acacacgtt  ggagacaac  tactcgacc  acggaggga  960
atccgagag  agtactact  tgccctcta  gagctggtt  tacgtggca  ctgcttctg  1020
tacggacac  cctcagagt  tgcacccgc  ccaggggca  cagcccatg  tgagggcat  1080
gtgcacgga  cttgcatct  caaacacaa  acacgtggc  tcaactgcg  gcagtgtca  1140
gatttctat  gtgacctgc  ctggcgtcc  gctgaggac  gccatagtc  tgcctgtag  1200
aagtgtgat  ggcatgggc  cacccacag  tgccacttc  acatggccg  atacctcgg  1260
tctggcaat  tgagtggag  tgtgtgtga  ggatgtcag  ataacacag  gtggcgcca  1320
tgtgagctc  gtcggccct  cttctaccg  gacccaacc  aggacctgc  ggatccggc  1380
gtgtgccgc  cctgtgatt  tgaccccat  ggttctcaa  acggtggtc  ctgtgattc  1440
catgatgac  ctgcactgg  actggtctc  ggccagtgt  gctgcaaag  acacgtggt  1500
ggcactcgc  gccagcaat  ccgtgatgg  ttctttggg  tcagcatca  tgacccgtc  1560
gggtgccgg  gatgtcaat  taatgcacg  ggcacagtg  ctgggagca  tccttgtga  1620
cccaacagt  gatcctgtt  ctgcaaacg  ctagtgact  gacgtggat  tgaccgctg  1680
ctgcctggc  actggggcc  gagcctcga  ctgctcggc  gccgcccct  tgactgcga  1740
gtgggtggt  ctttggatc  ccagtgtga  gagggcaca  gtcaatgcc  ctgccgcca  1800
cacatggtt  ggcgacgct  tgagcaggt  caacctggc  acttccggc  cttcctgga  1860
cacctaatt  gggaggctg  gaacacccg  gggcaggtg  tcgatgtgg  ggagcgcct  1920
gtgaccccc  gggaaactc  atcctggac  ggctcaggc  tcgtgcgac  acaggaagg  1980
cagaccctg  agttcctgg  ggcctctgt  ccgaacgcg  tggactatg  cctgctgct  2040
cgcttagag  cccaggtcc  tgagcaatg  gcagagttg  aactgattg  gcagcgtcc  2100
gggcctgtg  ctgcccaca  cctgtgtgg  catttggtg  ccagggatg  tcgcatcca  2160
gggactctg  aaccacatg  caggtactt  atatttcct  atcctgtct  ccttgagcc  2220
ggtatctcc  acaagctgc  tctgaagct  gtacggaca  ggggaagtg  ccagcctga  2280
actccctac  ctggacctg  cctgctcat  gactcgctg  tgctgctgc  ccgtgtcct  2340
gtgctagag  tgtttagtg  gggtgatgc  gctgccctg  agcgccagg  cacctttga  2400
cgctaccaa  gccatgagg  gggtctggt  cccagcaag  cttctccct  tgaggcctg  2460
gcacccctc  tcatcagcc  gtccaccct  atctacaat  gtgccctgc  atgtcagtg  2520
aaccctcaa  gttcactga  ttctgagtg  aaccctcat  gtggtcagt  cctgtgcaa  2580
cctggagtg  ttgggcgcc  ctgtgacac  tgtgcccct  gctactatg  ctttggccc  2640
acaggctgt  aagcctgcc  gtgcagccc  cgaggggca  tcagcagtc  ctgtgaaag  2700
accagtggg  aatgtctct  tcgaactgg  gcctttggg  ttcgctgtg  cgcctgcca  2760
cgtggccag  ggggattcc  tagctgccg  ccatgtgtc  gcaatgggc  tgcagatga  2820
tgcaacacc  acacaggcg  ttgcctggg  tgccgtgat  tcacagggg  tgagcactg  2880
gaaaggtgc  ttgctggtt  ccacgggga  ccacggctg  catatgggg  gcagtgccg  2940
ccctgtccc  gtcctgaag  ccctgggag  caacggcac  ttgctactt  ttgccacca  3000
gatgaatat  cccagcaga  tgtgtgcca  tgccgggca  gctatacgg  gctgcgatg  3060
gaagcttgt  cccctgggc  gtttgggga  ccatcaagg  caggtggcc  gtgccaact  3120
tgtgagtgc  gtgggaaca  tgacccaat  gatcctgat  cctgtgacc  acaccccgg  3180
caatgcctg  gctgtttac  ccacacaga  ggtccacac  gtgcccact  gaagcctgg  3240
ttccatggc  aggctgccc  gcagagctg  caccgctgc  catgcaacc  gctgggcac  3300
aatccgcag  agtgcccat  tcctgacca  tgccactgt  atccaagca  tgggcagtg  3360
ccatgcctc  ccaatgtcc  ggccctagc  gtagaccgc  gtgccccca  cttctggaa  3420
ctcaccagt  gccatggtt  ccagccttg  gcctgcctc  caagcccgg  agaaggccc  3480
acctgcaac  agttcacag  gcagtgcca  tgcctgtgc  gctttggag  gcggacttg  3540
tctgagtgc  aagagctcc  ctggggaga  cctgggttg  agtgccatg  ctgtgattg  3600
gactctcgt  gaatagata  acctcagtg  caccgcttc  caggtcact  cacgtgccg  3660
ccaggggtg  ctggtgtgc  ctgtgacca  tgtgcccgt  gcttctcag  aatctttcc  3720
gcctgccat  cctgccatg  atgcttcgg  gattgggac  gagtggtgc  ggacttggc  3780
gcccgtaca  agcgcctag  gcagcgggc  caggagttg  aacagacgg  tgtgctggg  3840
gcctttgag  gcagcttct  gcacatgca  gagaagctg  gcattgtgc  gggcatcgt  3900
ggtgcccgc  acacctcag  cgcctccac  gcacagctt  tggaggcca  agaggagct  3960
cggcgtgaa  ttggggagg  cactgagca  ctgactcag  tcgaggcag  cctgacaga  4020
gtgcaagat  agaacttca  tgccaacca  gcactaagt  gtctggagc  agataggct  4080
gcacttaat  tcacactgc  gcagctcga  cagcatctt  acttgctca  acattcaaa  4140
ttcctgggt  cctatgaca  catccggca  gcccatagc  agtctgcag  ggcagaacg  4200
cgtgccaat  cctcagccc  ggcagtacc  agccctgtg  gcaactcgg  aagtgctcg  4260
catcggaca  aggcactga  ggatgctca  aaggaggac  tcaacagca  acacatggc  4320
aaccagcgg  cacttggca  gctctctgc  catacccac  ccctgagcc  gacagacat  4380
aatgagctg  tgtgtgggg  ccagggatt  catcatgat  gtacaagcc  ttgtggggg  4440
gccggctgt  gagatgagg  tgggcagcc  cgctgtggg  gcctcagct  caatggggc  4500
gcggctaca  cagacctag  actgggccg  gcccggcac  cacaggcag  gctgcagcg  4560
gcactggca  aaggtggta  catcctcag  agagtggct  agactcgtc  gcaggcaag  4620
gaggcacag  agcgggccc  ggcagccct  gacaaggct  atgcttcca  gggacaggt  4680
gaacaggcc  accaggaac  tcaagaact  atccagagt  tgaaggact  cctcaacca  4740
gagggggct  atcctgata  cattgaaat  gtggccaca  gggtgctag  gctctccat  4800
ccagcttca  ctgagcaga  ccagcacct  gcgggcgcg  ttgcagagc  agtccggag  4860
ctggcagat  tggatgcga  cctggcacg  actgtagga  atgtgcgtc  tgccgagca  4920
ctactgcag  atgcacggc  ggcaaggag  tgggctgag  atgagaaac  gaaggcaga  4980
acagtacag  cagcactgg  ggaggccca  cgggcacag  gtattgccc  gggtgccat  5040
cggggggca  tggctgaca  acgggacac  gagcagacc  tgtaccagg  acaggagag  5100
atggcaggt  cagagcggg  actgagctc  gcaggtgaa  gggctcggc  gttggatgc  5160
ctcctggag  ctctgaaat  gaaacgggc  ggaaatagt  tggcagcct  tacagcaga  5220
gaaacggca  gcagtgccc  gggtcgtgc  caggaggct  agcagctgc  acgcggtcc  5280
ctgggtgat  agtaccaga  ggtgaaggc  ctagctgag  gcaaggccc  aggtgtgct  5340
gctgcacag  caagggcag  acaactgcc  gatgaggct  gggacctgt  gcaagccgc  5400
caggacaag  tgcagcggc  acaggaatt  gaaggcacc  atgaggaaa  tgagcgggc  5460
ctggagagt  aggcagccc  gttggacgg  ttggaggcc  ggatgcgca  cgtgcttca  5520
gccatcaac  tgcaggtgc  gatctacaa  acctgccag  gacccctgc  caaggccta  5580
cccagttcc  agcactgcc  cacatgcat  tctgcctat  cactgaaga  ctcttggcc  5640
ggcagggcc  ccaataaac  agtgtgaac  cccaaaaaa  aaa  5683



<210> 6294
<211> 1798
<212> PRT
<213> Homo sapiens
<308> P55268
<400> 6294

Met Glu Leu Thr Ser Arg Glu Arg Gly Arg Gly Gln Pro Leu Pro Trp 
  1               5                  10                  15
Glu Leu Arg Leu Gly Leu Leu Leu Ser Val Leu Ala Ala Thr Leu Ala 
             20                  25                  30
Gln Ala Pro Ala Pro Asp Val Pro Gly Cys Ser Arg Gly Ser Cys Tyr 
         35                  40                  45
Pro Ala Thr Gly Asp Leu Leu Val Gly Arg Ala Asp Arg Leu Thr Ala 
     50                  55                  60
Ser Ser Thr Cys Gly Leu Asn Gly Pro Gln Pro Tyr Cys Ile Val Ser 
 65                  70                  75                  80
His Leu Gln Asp Glu Lys Lys Cys Phe Leu Cys Asp Ser Arg Arg Pro 
                 85                  90                  95
Phe Ser Ala Arg Asp Asn Pro His Ser His Arg Ile Gln Asn Val Val 
             100                105                110
Thr Ser Phe Ala Pro Gln Arg Arg Ala Ala Trp Trp Gln Ser Glu Asn 
         115                120                125
Gly Ile Pro Ala Val Thr Ile Gln Leu Asp Leu Glu Ala Glu Phe His 
     130                135                140
Phe Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg Pro Ala Ala Met 
 145                150                155                160
Leu Val Glu Arg Ser Ala Asp Phe Gly Arg Thr Trp His Val Tyr Arg 
                 165                170                175
Tyr Phe Ser Tyr Asp Cys Gly Ala Asp Phe Pro Gly Val Pro Leu Ala 
             180                185                190
Pro Pro Arg His Trp Asp Asp Val Val Cys Glu Ser Arg Tyr Ser Glu 
         195                200                205
Ile Glu Pro Ser Thr Glu Gly Glu Val Ile Tyr Arg Val Leu Asp Pro 
     210                215                220
Ala Ile Pro Ile Pro Asp Pro Tyr Ser Ser Arg Ile Gln Asn Leu Leu 
 225                230                235                240
Lys Ile Thr Asn Leu Arg Val Asn Leu Thr Arg Leu His Thr Leu Gly 
                 245                250                255
Asp Asn Leu Leu Asp Pro Arg Arg Glu Ile Arg Glu Lys Tyr Tyr Tyr 
             260                265                270
Ala Leu Tyr Glu Leu Val Val Arg Gly Asn Cys Phe Cys Tyr Gly His 
         275                280                285
Ala Ser Glu Cys Ala Pro Ala Pro Gly Ala Pro Ala His Ala Glu Gly 
     290                295                300
Met Val His Gly Ala Cys Ile Cys Lys His Asn Thr Arg Gly Leu Asn 
 305                310                315                320
Cys Glu Gln Cys Gln Asp Phe Tyr Arg Asp Leu Pro Trp Arg Pro Ala 
                 325                330                335
Glu Asp Gly His Ser His Ala Cys Arg Lys Cys Glu Cys His Gly His 
             340                345                350
Thr His Ser Cys His Phe Asp Met Ala Val Tyr Leu Ala Ser Gly Asn 
         355                360                365
Val Ser Gly Gly Val Cys Asp Gly Cys Gln His Asn Thr Ala Gly Arg 
     370                375                380
His Cys Glu Leu Cys Arg Pro Phe Phe Tyr Arg Asp Pro Thr Lys Asp 
 385                390                395                400
Leu Arg Asp Pro Ala Val Cys Arg Ser Cys Asp Cys Asp Pro Met Gly 
                 405                410                415
Ser Gln Asp Gly Gly Arg Cys Asp Ser His Asp Asp Pro Ala Leu Gly 
             420                425                430
Leu Val Ser Gly Gln Cys Arg Cys Lys Glu His Val Val Gly Thr Arg 
         435                440                445
Cys Gln Gln Cys Arg Asp Gly Phe Phe Gly Leu Ser Ile Ser Asp Arg 
     450                455                460
Leu Gly Cys Arg Arg Cys Gln Cys Asn Ala Arg Gly Thr Val Pro Gly 
 465                470                475                480
Ser Thr Pro Cys Asp Pro Asn Ser Gly Ser Cys Tyr Cys Lys Arg Leu 
                 485                490                495
Val Thr Gly Arg Gly Cys Asp Arg Cys Leu Pro Gly His Trp Gly Leu 
             500                505                510
Ser His Asp Leu Leu Gly Cys Arg Pro Cys Asp Cys Asp Val Gly Gly 
         515                520                525
Ala Leu Asp Pro Gln Cys Asp Glu Gly Thr Gly Gln Cys His Cys Arg 
     530                535                540
Gln His Met Val Gly Arg Arg Cys Glu Gln Val Gln Pro Gly Tyr Phe 
 545                550                555                560
Arg Pro Phe Leu Asp His Leu Ile Trp Glu Ala Glu Asp Thr Arg Gly 
                 565                570                575
Gln Val Leu Asp Val Val Glu Arg Leu Val Thr Pro Gly Glu Thr Pro 
             580                585                590
Ser Trp Thr Gly Ser Gly Phe Val Arg Leu Gln Glu Gly Gln Thr Leu 
         595                600                605
Glu Phe Leu Val Ala Ser Val Pro Lys Ala Met Asp Tyr Asp Leu Leu 
     610                615                620
Leu Arg Leu Glu Pro Gln Val Pro Glu Gln Trp Ala Glu Leu Glu Leu 
 625                630                635                640
Ile Val Gln Arg Pro Gly Pro Val Pro Ala His Ser Leu Cys Gly His 
                 645                650                655
Leu Val Pro Lys Asp Asp Arg Ile Gln Gly Thr Leu Gln Pro His Ala 
             660                665                670
Arg Tyr Leu Ile Phe Pro Asn Pro Val Cys Leu Glu Pro Gly Ile Ser 
         675                680                685
Tyr Lys Leu His Leu Lys Leu Val Arg Thr Gly Gly Ser Ala Gln Pro 
     690                695                700
Glu Thr Pro Tyr Ser Gly Pro Gly Leu Leu Ile Asp Ser Leu Val Leu 
 705                710                715                720
Leu Pro Arg Val Leu Val Leu Glu Met Phe Ser Gly Gly Asp Ala Ala 
                 725                730                735
Ala Leu Glu Arg Gln Ala Thr Phe Glu Arg Tyr Gln Cys His Glu Glu 
             740                745                750
Gly Leu Val Pro Ser Lys Thr Ser Pro Ser Glu Ala Cys Ala Pro Leu 
         755                760                765
Leu Ile Ser Leu Ser Thr Leu Ile Tyr Asn Gly Ala Leu Pro Cys Gln 
     770                775                780
Cys Asn Pro Gln Gly Ser Leu Ser Ser Glu Cys Asn Pro His Gly Gly 
 785                790                795                800
Gln Cys Leu Cys Lys Pro Gly Val Val Gly Arg Arg Cys Asp Leu Cys 
                 805                810                815
Ala Pro Gly Tyr Tyr Gly Phe Gly Pro Thr Gly Cys Gln Ala Cys Gln 
             820                825                830
Cys Ser His Glu Gly Ala Leu Ser Ser Leu Cys Glu Lys Thr Ser Gly 
         835                840                845
Gln Cys Leu Cys Arg Thr Gly Ala Phe Gly Leu Arg Cys Asp Arg Cys 
     850                855                860
Gln Arg Gly Gln Trp Gly Phe Pro Ser Cys Arg Pro Cys Val Cys Asn 
 865                870                875                880
Gly His Ala Asp Glu Cys Asn Thr His Thr Gly Ala Cys Leu Gly Cys 
                 885                890                895
Arg Asp His Thr Gly Gly Glu His Cys Glu Arg Cys Ile Ala Gly Phe 
             900                905                910
His Arg Asp Pro Arg Leu Pro Tyr Gly Gly Gln Cys Arg Pro Cys Pro 
         915                920                925
Cys Pro Glu Gly Pro Gly Ser Gln Arg His Phe Ala Thr Ser Cys His 
     930                935                940
Gln Asp Glu Tyr Ser Gln Gln Ile Val Cys His Cys Arg Ala Gly Tyr 
 945                950                955                960
Thr Gly Leu Arg Cys Glu Ala Cys Ala Pro Gly His Phe Gly Asp Pro 
                 965                970                975
Ser Arg Pro Gly Gly Arg Cys Gln Leu Cys Glu Cys Ser Gly Asn Ile 
             980                985                990
Asp Pro Met Asp Pro Asp Ala Cys Asp Pro His Thr Gly Gln Cys Leu 
         995                1000                1005
Arg Cys Leu His His Thr Glu Gly Pro His Cys Ala His Cys Lys Pro 
     1010                1015                1020
Gly Phe His Gly Gln Ala Ala Arg Gln Ser Cys His Arg Cys Thr Cys 
 1025                1030                1035                1040
Asn Leu Leu Gly Thr Asn Pro Gln Gln Cys Pro Ser Pro Asp Gln Cys 
                 1045                1050                1055
His Cys Asp Pro Ser Ser Gly Gln Cys Pro Cys Leu Pro Asn Val Gln 
             1060                1065                1070
Gly Pro Ser Cys Asp Arg Cys Ala Pro Asn Phe Trp Asn Leu Thr Ser 
         1075                1080                1085
Gly His Gly Cys Gln Pro Cys Ala Cys His Pro Ser Arg Ala Arg Gly 
     1090                1095                1100
Pro Thr Cys Asn Glu Phe Thr Gly Gln Cys His Cys Arg Ala Gly Phe 
 1105                1110                1115                1120
Gly Gly Arg Thr Cys Ser Glu Cys Gln Glu Leu His Trp Gly Asp Pro 
                 1125                1130                1135
Gly Leu Gln Cys His Ala Cys Asp Cys Asp Ser Arg Gly Ile Asp Thr 
             1140                1145                1150
Pro Gln Cys His Arg Phe Thr Gly His Cys Ser Cys Arg Pro Gly Val 
         1155                1160                1165
Ser Gly Val Arg Cys Asp Gln Cys Ala Arg Gly Phe Ser Gly Ile Phe 
     1170                1175                1180
Pro Ala Cys His Pro Cys His Ala Cys Phe Gly Asp Trp Asp Arg Val 
 1185                1190                1195                1200
Val Gln Asp Leu Ala Ala Arg Thr Gln Arg Leu Glu Gln Arg Ala Gln 
                 1205                1210                1215
Glu Leu Gln Gln Thr Gly Val Leu Gly Ala Phe Glu Ser Ser Phe Trp 
             1220                1225                1230
His Met Gln Glu Lys Leu Gly Ile Val Gln Gly Ile Val Gly Ala Arg 
         1235                1240                1245
Asn Thr Ser Ala Ala Ser Thr Ala Gln Leu Val Glu Ala Thr Glu Glu 
     1250                1255                1260
Leu Arg Arg Glu Ile Gly Glu Ala Thr Glu His Leu Thr Gln Leu Glu 
 1265                1270                1275                1280
Ala Asp Leu Thr Asp Val Gln Asp Glu Asn Phe Asn Ala Asn His Ala 
                 1285                1290                1295
Leu Ser Gly Leu Glu Arg Asp Arg Leu Ala Leu Asn Leu Thr Leu Arg 
             1300                1305                1310
Gln Leu Asp Gln His Leu Asp Leu Leu Lys His Ser Asn Phe Leu Gly 
         1315                1320                1325
Ala Tyr Asp Ser Ile Arg His Ala His Ser Gln Ser Ala Glu Ala Glu 
     1330                1335                1340
Arg Arg Ala Asn Thr Ser Ala Leu Ala Val Pro Ser Pro Val Ser Asn 
 1345                1350                1355                1360
Ser Ala Ser Ala Arg His Arg Thr Glu Ala Leu Met Asp Ala Gln Lys 
                 1365                1370                1375
Glu Asp Phe Asn Ser Lys His Met Ala Asn Gln Arg Ala Leu Gly Lys 
             1380                1385                1390
Leu Ser Ala His Thr His Thr Leu Ser Leu Thr Asp Ile Asn Glu Leu 
         1395                1400                1405
Val Cys Gly Ala Pro Gly Asp Ala Pro Cys Ala Thr Ser Pro Cys Gly 
     1410                1415                1420
Gly Ala Gly Cys Arg Asp Glu Asp Gly Gln Pro Arg Cys Gly Gly Leu 
 1425                1430                1435                1440
Ser Cys Asn Gly Ala Ala Ala Thr Ala Asp Leu Ala Leu Gly Arg Ala 
                 1445                1450                1455
Arg His Thr Gln Ala Glu Leu Gln Arg Ala Leu Ala Glu Gly Gly Ser 
             1460                1465                1470
Ile Leu Ser Arg Val Ala Glu Thr Arg Arg Gln Ala Ser Glu Ala Gln 
         1475                1480                1485
Gln Arg Ala Gln Ala Ala Leu Asp Lys Ala Asn Ala Ser Arg Gly Gln 
     1490                1495                1500
Val Glu Gln Ala Asn Gln Glu Leu Gln Glu Leu Ile Gln Ser Val Lys 
 1505                1510                1515                1520
Asp Phe Leu Asn Gln Glu Gly Ala Asp Pro Asp Ser Ile Glu Met Val 
                 1525                1530                1535
Ala Thr Arg Val Leu Glu Leu Ser Ile Pro Ala Ser Ala Glu Gln Ile 
             1540                1545                1550
Gln His Leu Ala Gly Ala Ile Ala Glu Arg Val Arg Ser Leu Ala Asp 
         1555                1560                1565
Val Asp Ala Ile Leu Ala Arg Thr Val Gly Asp Val Arg Arg Ala Glu 
     1570                1575                1580
Gln Leu Leu Gln Asp Ala Arg Arg Ala Arg Ser Trp Ala Glu Asp Glu 
 1585                1590                1595                1600
Lys Gln Lys Ala Glu Thr Val Gln Ala Ala Leu Glu Glu Ala Gln Arg 
                 1605                1610                1615
Ala Gln Gly Ile Ala Gln Gly Ala Ile Arg Gly Ala Val Ala Asp Thr 
             1620                1625                1630
Arg Asp Thr Glu Gln Thr Leu Tyr Gln Val Gln Glu Arg Met Ala Gly 
         1635                1640                1645
Ala Glu Arg Ala Leu Ser Ser Ala Gly Glu Arg Ala Arg Gln Leu Asp 
     1650                1655                1660
Ala Leu Leu Glu Ala Leu Lys Leu Lys Arg Ala Gly Asn Ser Leu Ala 
 1665                1670                1675                1680
Ala Ser Thr Ala Glu Glu Thr Ala Gly Ser Ala Gln Gly Arg Ala Gln 
                 1685                1690                1695
Glu Ala Glu Gln Leu Leu Arg Gly Pro Leu Gly Asp Gln Tyr Gln Thr 
             1700                1705                1710
Val Lys Ala Leu Ala Glu Arg Lys Ala Gln Gly Val Leu Ala Ala Gln 
         1715                1720                1725
Ala Arg Ala Glu Gln Leu Arg Asp Glu Ala Arg Asp Leu Leu Gln Ala 
     1730                1735                1740
Ala Gln Asp Lys Leu Gln Arg Leu Gln Glu Leu Glu Gly Thr Tyr Glu 
 1745                1750                1755                1760
Glu Asn Glu Arg Ala Leu Glu Ser Lys Ala Ala Gln Leu Asp Gly Leu 
                 1765                1770                1775
Glu Ala Arg Met Arg Ser Val Leu Gln Ala Ile Asn Leu Gln Val Gln 
             1780                1785                1790
Ile Tyr Asn Thr Cys Gln 
         1795



<210> 6295
<211> 457
<212> DNA
<213> Rattus norvegicus
<308> AA924084
<400> 6295

ttttttttt  tttttttgg  aaaccagct  agttttatt  ggctgctga  agaaaggag  60
atggcgggt  ctaaggcag  tgtatcact  ttaagtccc  tgcaccttg  gagtggcta  120
gccaccagc  gcgctgcca  ctgtgcacg  tcagccaag  tgcttatgt  atcttgtga  180
atgccctcc  ccccctcga  aagaaaggc  agggtcttg  acaggtgat  atggctgct  240
taattcaag  cggcagtta  cacagatgg  catctaaga  atctctacc  ctggttcta  300
agggtaaag  aaaactatt  actctttaa  gagagggtg  tgacacatc  atccacagg  360
aactaactg  taagatgtt  tatttcact  ttgagtttt  acatcgtcc  gattactct  420
tgtaaggag  aactagaat  tttaaaaga  atacacg  457



<210> 6296
<211> 245
<212> PRT
<213> Rattus norvegicus
<308> P35213
<400> 6296

Thr Met Asp Lys Ser Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln 
  1               5                  10                  15
Ala Glu Arg Tyr Asp Asp Met Ala Ala Ala Met Lys Ala Val Thr Glu 
             20                  25                  30
Gln Gly His Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala 
         35                  40                  45
Tyr Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Ile Ser 
     50                  55                  60
Ser Ile Glu Gln Lys Thr Glu Arg Asn Glu Lys Lys Gln Gln Met Gly 
 65                  70                  75                  80
Lys Glu Tyr Arg Glu Lys Ile Glu Ala Glu Leu Gln Asp Ile Cys Ser 
                 85                  90                  95
Asp Val Leu Glu Leu Leu Asp Lys Tyr Leu Ile Leu Asn Ala Thr His 
             100                105                110
Ala Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Phe Arg 
         115                120                125
Tyr Leu Ser Glu Val Ala Ser Gly Asp Asn Lys Gln Thr Thr Val Ser 
     130                135                140
Asn Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu 
 145                150                155                160
Met Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser 
                 165                170                175
Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu 
             180                185                190
Ala Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Asn 
         195                200                205
Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp 
     210                215                220
Asn Leu Thr Leu Trp Thr Ser Glu Asn Gln Gly Asp Glu Gly Asp Ala 
 225                230                235                240
Gly Glu Gly Glu Asn 
                 245



<210> 6297
<211> 389
<212> DNA
<213> Rattus norvegicus
<308> AA924772
<400> 6297

ttttttttt  tttttttgc  gtgcatggg  tttattcac  cccccggag  aggaagcca  60
ggagggggg  aacagccac  ccccaccag  gacacgcag  actattcac  taggctgtg  120
gggagtcct  actggcagc  gctgcattt  tcggccttg  ccccctctt  gcctttgca  180
acacagtcc  tggcacact  ctcacatcc  gcagggcaa  aggagcagc  gctcttctt  240
cagttcgtg  atttgcagc  cttgcattt  catttgtcc  agcaggtgc  ggaaccacc  300
gtaggacag  ggcaggtct  agggtccat  tccaggcca  cagccgcga  agactgtag  360
ttagttcct  caggcaagc  ctcgtgccg  389



<210> 6298
<211> 66
<212> PRT
<213> Rattus norvegicus
<308> P37361
<400> 6298

Met Asp Pro Glu Thr Cys Pro Cys Pro Thr Gly Gly Ser Cys Thr Cys 
  1               5                  10                  15
Ser Asp Lys Cys Lys Cys Lys Gly Cys Lys Cys Thr Asn Cys Lys Lys 
             20                  25                  30
Ser Cys Cys Ser Cys Cys Pro Ala Gly Cys Glu Lys Cys Ala Lys Asp 
         35                  40                  45
Cys Val Cys Lys Gly Glu Glu Gly Ala Lys Ala Glu Lys Cys Ser Cys 
     50                  55                  60
Cys Gln 
 65



<210> 6299
<211> 556
<212> DNA
<213> Rattus norvegicus
<308> AA924909
<400> 6299

cggccgctt  tacatcact  gagtcttcc  aatccttgc  ggtctgtgt  tgatgagtg  60
agcggccat  tacacagtg  gacacagtg  gtggcatgt  aacaacgac  actcctatg  120
ctttgctta  atcctggcc  gggtggctt  cccgctggc  ctccttagt  gcatcatct  180
cgtgatcct  cggaaacgc  aatgaggcg  ccgacgcac  atccgtcta  gctctgagc  240
tgcataggg  acacaggga  ggaggaagg  aaccagaaa  ccaaaccaa  caacccaaa  300
gagctagcc  ccaaaccca  acgcaagcc  aaccaaaca  aacacagtt  agtggggat  360
gctgtcgat  gaagatgta  ataatatct  tggtttata  aacctattt  taacacttt  420
tacatacat  tacatagga  tgtttgctt  ttatgttga  cgtcagcct  gtgttgaat  480
ttaaacgac  ctacatcct  acactataa  caagctcag  attttcgtt  tgtttcgtt  540
ttttcatct  tttgtt  556



<210> 6300
<211> 160
<212> PRT
<213> Rattus norvegicus
<308> P25094
<400> 6300

Met Leu Leu Leu Leu Leu Gly Ile Leu Phe Leu His Ile Ala Val Leu 
  1               5                  10                  15
Val Leu Leu Phe Val Ser Thr Ile Val Ser Gln Trp Leu Val Gly Asn 
             20                  25                  30
Gly His Arg Thr Asp Leu Trp Gln Asn Cys Thr Thr Ser Ala Leu Gly 
         35                  40                  45
Ala Val Gln His Cys Tyr Ser Ser Ser Val Ser Glu Trp Leu Gln Ser 
     50                  55                  60
Val Gln Ala Thr Met Ile Leu Ser Val Ile Phe Ser Val Leu Ser Leu 
 65                  70                  75                  80
Phe Leu Phe Phe Cys Gln Leu Phe Thr Leu Thr Lys Gly Gly Arg Phe 
                 85                  90                  95
Tyr Ile Thr Gly Val Phe Gln Ile Leu Ala Gly Leu Cys Val Met Ser 
             100                105                110
Ala Ala Ala Ile Tyr Thr Val Arg His Ser Glu Trp His Val Asn Asn 
         115                120                125
Asp Tyr Ser Tyr Gly Phe Ala Tyr Ile Leu Ala Trp Val Ala Phe Pro 
     130                135                140
Leu Ala Leu Leu Ser Gly Ile Ile Tyr Val Ile Leu Arg Lys Arg Glu 
 145                150                155                160



<210> 6301
<211> 1661
<212> DNA
<213> Homo sapiens
<308> M94048
<400> 6301

gcgctctcc  cgcaggcag  aactccgct  agcagaact  gccgccaga  tgctcctcc  60
gttgctgag  atcatcgtc  tccacgtcg  ggtgctggt  ctgctgttc  tctccacga  120
cgtcagcca  tggatcgtg  gcaatggac  cgcaactga  ctctggcag  actgtagca  180
ctcttcctc  ggaaatgtc  accactgtt  ctcatcatc  ccaaacgaa  ggctgcagt  240
tgtccaggc  accatgatc  tgtcgatca  cttcagcat  ctgtctctg  tcctgttct  300
ctgccaact  ttcaccctc  ccaaggggg  caggtttta  atcactgga  tcttccaaa  360
tcttgctgg  ctgtgcgtg  tgagtgctg  ggccatcta  acggtgagg  acccggagt  420
gcatctcaa  tcggattac  cctacggtt  cgcctacat  ctggcctgg  tggccttcc  480
cctggccct  ctcagcggt  tcatctatg  gatcttgcg  aaacgcgaa  gaggcgccc  540
gacggtctg  ctgaggctc  gagcgtaca  agggaaggg  ggaagggaa  acagaaagc  600
gacaaagaa  aaagagcta  cccaaaatc  caaactcaa  ccaaaccaa  cagaaagca  660
tggaggtgg  ggttgctgt  gattgaaga  gtatataat  tctccggtt  ataaaacct  720
tttataaca  tttttacat  tatgtacat  gtattgttt  ctttttatg  tgaccatca  780
cctcgtgtt  agccttaaa  aagtagcta  ggaacttta  atcctaaca  tataatcca  840
ctcagtatt  ttgttttgt  ttttgtttg  ttgttttgt  ttacccaga  ataagataa  900
tccatctcg  cccttccct  tcatctgaa  gaagatacc  ccctcccag  ccacctcat  960
tagaaaacc  aagtgtggg  agaaacccc  aatgtccaa  agccctttt  tggtgggtg  1020
cccagtgca  ccaacagaa  cagccgctg  ccgaacctc  gtgtgaagc  ttacgcgca  1080
acggacaaa  tgcccaaac  ggagccctc  aaaaacgcg  cttgtggca  tggcatact  1140
gccttacag  tggagtatc  tcgtcacac  tctaaatga  aaatcagtg  caacaagtc  1200
ttgaaatgg  gctatggat  taccattcc  tattatcac  aatcatcta  acaactcac  1260
ggaaatcca  ttaacaatt  tataacata  gatagaatg  agacctgaa  aattctgtg  1320
aatataaat  gtttataac  gcttttgta  ctagctagg  tgctattat  actataatg  1380
gtaaatcat  aagccttcg  cactcccac  gttttctta  ggtcggagc  tcacaacaa  1440
cgtctagac  ccttgggac  gtgagttcc  agagcttgg  tgggtctag  ctgttctgt  1500
cctccaagg  ctgtctggc  atgacttgt  ttggccacc  actgtagat  tatatatgg  1560
gcccttctg  tgctaagac  ccagacctt  tgtttttgc  ttgcatttt  tgattttat  1620
ccaactgtg  ggactaaga  gcattaaaa  aaacatcag  g  1661



<210> 6302
<211> 160
<212> PRT
<213> Homo sapiens
<308> Q01453
<400> 6302

Met Leu Leu Leu Leu Leu Ser Ile Ile Val Leu His Val Ala Val Leu 
  1               5                  10                  15
Val Leu Leu Phe Val Ser Thr Ile Val Ser Gln Trp Ile Val Gly Asn 
             20                  25                  30
Gly His Ala Thr Asp Leu Trp Gln Asn Cys Ser Thr Ser Ser Ser Gly 
         35                  40                  45
Asn Val His His Cys Phe Ser Ser Ser Pro Asn Glu Trp Leu Gln Ser 
     50                  55                  60
Val Gln Ala Thr Met Ile Leu Ser Ile Ile Phe Ser Ile Leu Ser Leu 
 65                  70                  75                  80
Phe Leu Phe Phe Cys Gln Leu Phe Thr Leu Thr Lys Gly Gly Arg Phe 
                 85                  90                  95
Tyr Ile Thr Gly Ile Phe Gln Ile Leu Ala Gly Leu Cys Val Met Ser 
             100                105                110
Ala Ala Ala Ile Tyr Thr Val Arg His Pro Glu Trp His Leu Asn Ser 
         115                120                125
Asp Tyr Ser Tyr Gly Phe Ala Tyr Ile Leu Ala Trp Val Ala Phe Pro 
     130                135                140
Leu Ala Leu Leu Ser Gly Val Ile Tyr Val Ile Leu Arg Lys Arg Glu 
 145                150                155                160



<210> 6303
<211> 530
<212> DNA
<213> Rattus norvegicus
<308> AA925246
<400> 6303

ttttttttt  tttttttca  attgtaaac  agatacttt  tttcaaatg  aaagaagga  60
acatttttt  catcatgta  gtttgtcaa  gaatcatga  tagatttgt  catctcagt  120
gaagactga  atctgcact  gtgtatata  aagacaggg  cttgggaag  tcaccttag  180
cctccagcc  gctggagga  tccagcgtc  atcagcaca  aggccacaa  tctcagaaa  240
tgcccagtt  tgtccacaa  gaaaagggc  ttgggtgga  agaagggaa  cagaggtgt  300
actccaaag  caccgttcg  ttgcactgt  gaggaagga  tgtgagaac  gatgggctg  360
ctggcttga  tcacatctt  gggaagctg  ccaggttgg  aatgccaca  gcattgttc  420
tattccgag  caagagaac  tagcctttg  ttccccagc  ttctcccca  ctgttttta  480
ttatccagt  cttatttcc  ttctgggtg  catagccca  caccaacacg  530



<210> 6304
<211> 329
<212> PRT
<213> Rattus norvegicus
<308> O35186
<400> 6304

Met Trp Val Phe Lys Phe Leu Leu Leu Pro Val Val Ser Phe Ala Leu 
  1               5                  10                  15
Ser Pro Glu Glu Thr Leu Asp Thr Gln Trp Glu Leu Trp Lys Lys Thr 
             20                  25                  30
His Gly Lys Gln Tyr Asn Ser Lys Val Asp Glu Ile Ser Arg Arg Leu 
         35                  40                  45
Ile Trp Glu Lys Asn Leu Lys Lys Ile Ser Val His Asn Leu Glu Ala 
     50                  55                  60
Ser Leu Gly Ala His Thr Tyr Glu Leu Ala Met Asn His Leu Gly Asp 
 65                  70                  75                  80
Met Thr Ser Glu Glu Val Val Gln Lys Met Thr Gly Leu Arg Val Pro 
                 85                  90                  95
Pro Ser Arg Ser Phe Ser Asn Asp Thr Leu Tyr Thr Pro Glu Trp Glu 
             100                105                110
Gly Arg Val Pro Asp Ser Ile Asp Tyr Arg Lys Lys Gly Tyr Val Thr 
         115                120                125
Pro Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser 
     130                135                140
Ala Gly Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu 
 145                150                155                160
Ala Leu Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Tyr Gly 
                 165                170                175
Cys Gly Gly Gly Tyr Met Thr Thr Ala Phe Gln Tyr Val Gln Gln Asn 
             180                185                190
Gly Gly Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Asp Glu 
         195                200                205
Ser Cys Met Tyr Asn Ala Thr Ala Lys Ala Ala Lys Cys Arg Gly Tyr 
     210                215                220
Arg Glu Ile Pro Val Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala 
 225                230                235                240
Arg Val Gly Pro Val Ser Val Ser Ile Asp Ala Ser Leu Thr Ser Phe 
                 245                250                255
Gln Phe Tyr Ser Arg Gly Val Tyr Tyr Asp Glu Asn Cys Asp Arg Asp 
             260                265                270
Asn Val Asn His Ala Val Leu Val Val Gly Tyr Gly Thr Gln Lys Gly 
         275                280                285
Asn Lys Tyr Trp Ile Ile Lys Asn Ser Trp Gly Glu Ser Trp Gly Asn 
     290                295                300
Lys Gly Tyr Val Leu Leu Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile 
 305                310                315                320
Thr Asn Leu Ala Ser Phe Pro Lys Met 
                 325



<210> 6305
<211> 1669
<212> DNA
<213> Homo sapiens
<308> X82153
<400> 6305

gaaacaagc  ctggattcc  tatcccact  ccaaaaccg  atggttcag  ttatcgcta  60
tgcagcttt  atcataata  acacctttg  tgccgaaac  aagccagac  acagatttc  120
atcagcagg  tgtgggggc  caaggttct  ctgctacct  tggtgagct  tgctctgta  180
cctgaggag  tactggaca  ccactggga  ctatggaag  agacccaca  gaagcaata  240
aacaacaag  tggatgaaa  ctctcggcg  ttaatttgg  aaaaaaacc  gaagtatat  300
tccatccat  accttgagg  ttctcttgg  gtccataca  atgaactgg  tatgaacca  360
ctgggggac  tgaccagtg  agaggtggt  cagaagatg  ctggactca  agtacccct  420
tctcattcc  gcagtaatg  cacccttta  atcccagaa  gggaaggta  agccccaga  480
tctgtcgac  atcgaaaga  aggatatgt  actcctgtc  aaaatcagg  tcagtgtgg  540
tcctgttgg  cttttagct  tgtgggtgc  ctggagggc  aactcaaga  gaaaactgg  600
aaactctta  atctgagtc  ccagaacct  gtggattgt  tgtctgaga  tgatggctg  660
ggagggggc  acatgacca  tgccttcca  tatgtgcag  agaaccggg  tattgactc  720
gaagatgcc  acccatatg  gggacagga  gagagttgt  tgtacaacc  aacaggcaa  780
gcagctaaa  gcagagggt  cagagagat  cccgagggg  atgagaaag  cctgaagag  840
gcagtggcc  gagtgggac  tgtctctgt  gccattgat  caagcctga  ctccttcca  900
ttttacagc  aaggtgtgt  ttatgatga  agctgcaat  gcgataatc  gaaccatgc  960
gttttggca  tgggatatg  aatccagaa  ggaaacaag  actggataa  taaaaacag  1020
tggggagaa  actggggaa  caaaggata  atcctcatg  ctcgaaata  gaacaacgc  1080
tgtggcatt  ccaacctgg  cagcttccc  aagatgtga  tccagccag  caaatccat  1140
ctgctcttc  atttcttcc  cgatggtgc  gtgtaacga  gcactttgg  agggagttg  1200
tgtgctatt  ttgaagcag  tgtggtgat  ctgagattg  ctgttcagt  tccccattt  1260
tttgtgctt  aaatgatcc  tcctacttt  cttctctcc  cccatgacc  ttttcactg  1320
ggccatcag  actttccct  acagctgtg  actcttagg  taagagatg  gactacagc  1380
tgcccctga  tgtgttgtc  cagggctga  gctgtacag  tacaggctg  agattttca  1440
ataggttag  ttctcattc  cgggactag  tagctttaa  caccctaga  gactagggt  1500
atctgactt  tcacttcct  agttccctt  tatatcctc  aggtagaaa  gtctatgtt  1560
tctactcca  ttcataaat  tattcataa  tctttggta  aagtttaca  gataaaaag  1620
aatgtgatt  gtcttccct  ctttgcact  ttgaaataa  gtatttatc  1669



<210> 6306
<211> 329
<212> PRT
<213> Homo sapiens
<308> P43235
<400> 6306

Met Trp Gly Leu Lys Val Leu Leu Leu Pro Val Val Ser Phe Ala Leu 
  1               5                  10                  15
Tyr Pro Glu Glu Ile Leu Asp Thr His Trp Glu Leu Trp Lys Lys Thr 
             20                  25                  30
His Arg Lys Gln Tyr Asn Asn Lys Val Asp Glu Ile Ser Arg Arg Leu 
         35                  40                  45
Ile Trp Glu Lys Asn Leu Lys Tyr Ile Ser Ile His Asn Leu Glu Ala 
     50                  55                  60
Ser Leu Gly Val His Thr Tyr Glu Leu Ala Met Asn His Leu Gly Asp 
 65                  70                  75                  80
Met Thr Ser Glu Glu Val Val Gln Lys Met Thr Gly Leu Lys Val Pro 
                 85                  90                  95
Leu Ser His Ser Arg Ser Asn Asp Thr Leu Tyr Ile Pro Glu Trp Glu 
             100                105                110
Gly Arg Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Thr 
         115                120                125
Pro Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser 
     130                135                140
Val Gly Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu 
 145                150                155                160
Asn Leu Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly 
                 165                170                175
Cys Gly Gly Gly Tyr Met Thr Asn Ala Phe Gln Tyr Val Gln Lys Asn 
             180                185                190
Arg Gly Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu Glu 
         195                200                205
Ser Cys Met Tyr Asn Pro Thr Gly Lys Ala Ala Lys Cys Arg Gly Tyr 
     210                215                220
Arg Glu Ile Pro Glu Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala 
 225                230                235                240
Arg Val Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Thr Ser Phe 
                 245                250                255
Gln Phe Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Ser Asp 
             260                265                270
Asn Leu Asn His Ala Val Leu Ala Val Gly Tyr Gly Ile Gln Lys Gly 
         275                280                285
Asn Lys His Trp Ile Ile Lys Asn Ser Trp Gly Glu Asn Trp Gly Asn 
     290                295                300
Lys Gly Tyr Ile Leu Met Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile 
 305                310                315                320
Ala Asn Leu Ala Ser Phe Pro Lys Met 
                 325



<210> 6307
<211> 518
<212> DNA
<213> Rattus norvegicus
<308> AA925248
<400> 6307

ttttttttt  tttttttga  tctgaaatt  cgtttactt  attgtccaa  gcaagttgg  60
aaattcatt  agtttctga  gatcgaaag  agataacaa  agttaaggc  cgagtccat  120
cgttcatta  aaaatacag  ctcgagaat  caatggcat  gagtatcat  aaacccatt  180
aaagcttct  atttaagcc  gtagaatat  tatatatat  tattttttt  ttcttttca  240
ttctggagg  cttcatagg  acggtgtaa  cagtcttta  acaaatgga  aaaatatca  300
attctcaaa  tacatgagt  gaagtaaac  actatgtga  gaaatcaaa  ccaactatt  360
atattaaca  aaataatat  agtagttaa  actaatgtt  gttatttta  agattctca  420
atataaaac  tttgcatga  tatgtatga  aagatataa  agaaataag  gaaacataa  480
tgagctaat  tgcatataa  gatgttata  aatgccaa  518



<210> 6308
<211> 1702
<212> PRT
<213> Rattus norvegicus
<308> CAA70364
<400> 6308

Met Leu Thr Ser Pro Glu Pro Lys Gly Leu Val Pro Phe Thr Ala Glu 
  1               5                  10                  15
Ser Leu Glu Leu Ile Lys Asn His Ile Ala Lys Lys Cys Asn Glu Glu 
             20                  25                  30
His Glu Glu Glu Asp Leu Lys Pro Ser Arg Asp Ile Glu Ala Gly Lys 
         35                  40                  45
Lys Leu Pro Phe Ala Tyr Gly Thr Leu Pro Gln Gly Thr Val Ser Glu 
     50                  55                  60
Pro Leu Glu Asp Val Asp Pro Tyr Tyr Tyr Val Lys Arg Asn Thr Phe 
 65                  70                  75                  80
Met Val Leu Asn Arg Asn Arg Val Ile Phe Arg Phe Asn Ala Val Ser 
                 85                  90                  95
Ile Leu Cys Thr Leu Ser Pro Leu Ser Ser Leu Arg Arg Ala Val Ile 
             100                105                110
Lys Val Leu Val His Pro Leu Leu Arg Leu Leu Ile Leu Ile Ser Val 
         115                120                125
Leu Thr Asp Ser Ile Leu Met Cys Met Ser Asn Leu Pro Glu Trp Ile 
     130                135                140
Leu Ala Val Glu Asn Thr Cys Leu Gly Ile Tyr Thr Phe Glu Ile Leu 
 145                150                155                160
Val Lys Val Ile Ala Arg Gly Ile Trp Ala Gly Ser Phe Ser Phe Leu 
                 165                170                175
Gly Asp Leu Trp Asn Trp Leu Asp Phe Ser Val Thr Leu Phe Glu Leu 
             180                185                190
Ile Thr Arg Ser Ser Pro Leu Ser Ser Leu Pro Met Phe Lys Thr Ile 
         195                200                205
Arg Thr Leu Arg Ile Leu Lys Ile Ile Pro Leu Asn His Gly Leu Gln 
     210                215                220
Ser Ile Val Val Thr Leu Val Gln Cys Leu Lys Lys Leu Leu Gly Ala 
 225                230                235                240
Ile Ala Leu Ala Leu Phe Phe Leu Thr Val Ser Ser Leu Phe Gly Met 
                 245                250                255
Gly Leu Phe Met Gly Asn Leu Lys His Lys Cys Val Arg Trp Pro Gln 
             260                265                270
Glu Asp Gly Asn Asp Val Met Tyr Ser Gly Thr Gly Ser Gln Tyr His 
         275                280                285
Ile Leu Glu Arg Glu Asn Phe Tyr Tyr Met Glu Gly Ala Arg Tyr Ala 
     290                295                300
Leu Leu Cys Gly Asn Lys Thr Asp Ala Gly Leu Cys Pro Glu Gly Tyr 
 305                310                315                320
Met Cys Val Lys Glu Gly Ser Asn Pro Asp Asn Gly Phe Thr Ser Phe 
                 325                330                335
Asp Asn Phe Gly Trp Ala Leu Leu Ala Met Phe Arg Leu Met Thr Gln 
             340                345                350
Asp Tyr Pro Glu Leu Leu Tyr His Gln Ile Leu Tyr Ala Ser Gly Lys 
         355                360                365
Ile Tyr Met Ile Phe Phe Val Leu Ile Ser Phe Trp Phe Ala Phe Tyr 
     370                375                380
Met Ala Ser Leu Phe Leu Gly Ile Leu Thr Met Ala Tyr Glu Gln Glu 
 385                390                395                400
Lys Gln Arg Ala Ser Glu Glu Ser Arg Asp Met Asp Ser Lys Cys His 
                 405                410                415
Gln Thr Val Lys Glu Phe Glu Glu Glu His Glu Gly Ala Glu Leu Gln 
             420                425                430
Cys Ile Trp Phe Tyr Glu Glu Val Leu Asp Leu Leu Gly Leu Glu Leu 
         435                440                445
Cys Ile Lys Glu Met Glu Thr Thr Gln Ile Glu Met Lys Lys Arg Ser 
     450                455                460
Pro Thr Ser Ile Asn Thr Thr Leu Asp Ile Leu Glu Asp Thr Ala Leu 
 465                470                475                480
Gly His Lys Glu Glu Pro Glu Thr Ser Arg Lys Glu Cys Pro Leu Cys 
                 485                490                495
Trp Tyr Lys Phe Thr Lys Thr Cys Phe Ile Trp Lys Cys Ser Pro Cys 
             500                505                510
Trp Ile Lys Leu Asn Glu Phe Ala Asp Arg Ile Ile Thr His Pro Leu 
         515                520                525
Phe Asp Leu Phe Leu Val Ile Cys Ile Ile Leu Asn Ile Cys Phe Leu 
     530                535                540
Ala Leu Glu His Phe Pro Met Ser Glu Glu Leu Met Ser Leu Leu Ala 
 545                550                555                560
Ile Gly Asn Leu Val Phe Ile Gly Ile Tyr Thr Ile Glu Met Ile Leu 
                 565                570                575
Lys Ile Ile Ala Met His Pro Tyr Gly Tyr Phe Gln Ile Ser Trp His 
             580                585                590
Ile Phe Asp Ser Ile Leu Val Val Leu Gly Leu Thr Glu Met Leu Leu 
         595                600                605
Ala Asp Ile Glu Glu Ile Thr Val Phe Ile Leu Val Pro Leu Ile Phe 
     610                615                620
Ile Lys Leu Gly Lys Tyr Ala Pro Pro Phe Lys Asn Leu Met Arg Ile 
 625                630                635                640
Leu Gly Arg Ala Leu Val Ala Leu Lys Asp Leu Val Leu Leu Val Ser 
                 645                650                655
Ile Phe Ile Tyr Phe Ser Ala Val Phe Gly Met Lys Leu Phe Gly Arg 
             660                665                670
Ser Tyr Lys Asp Cys Val Cys His Val Asp Gln Asp Cys Gln Arg Gln 
         675                680                685
Arg Trp His Met Ser Asp Phe Leu His Ala Tyr Val Thr Val Phe Arg 
     690                695                700
Ile Leu Cys Gly Glu Trp Ile Glu Thr Leu Trp Glu Cys Met Glu Val 
 705                710                715                720
Ala Gly Glu Ala Trp Cys Ile Pro Phe Tyr Met Met Val Ile Leu Ile 
                 725                730                735
Gly Asn Leu Leu Ile Leu Tyr Leu Phe Val Gly Leu Val Ser Ser Phe 
             740                745                750
Ala Ser Tyr Asp Ala Thr Thr Glu Val Ser Lys Glu Ala Lys Asn Leu 
         755                760                765
Gln Leu Ala Val Ala Trp Ile Lys Met Val Ile Asn Cys Val Leu Leu 
     770                775                780
Lys Ile Leu Cys Lys Glu Lys Thr Val Ser Thr Glu Ala Thr Asp Gln 
 785                790                795                800
Thr Cys Asp Pro Ser Val Lys Glu Asn Ile Ser Gly His Thr Leu Ser 
                 805                810                815
Glu Leu Ser Asn Thr Gln Thr Phe Leu Arg Tyr Lys Asp Gln Ser Ser 
             820                825                830
Gly Thr Glu Lys Thr Pro Val Thr Glu Ser Glu Ser Gln Ser Leu Ile 
         835                840                845
Ala Ser Pro Ser Val Ser Glu Thr Val Pro Ile Ala Ser Gly Glu Ser 
     850                855                860
Asp Ile Glu Asn Leu Asp Asn Lys Glu Thr Arg Ser Lys Ser Ala Asn 
 865                870                875                880
Gly Ser Ser Lys Glu Lys Met Lys Gln Ser Ser Ser Ser Glu Cys Ser 
                 885                890                895
Thr Val Asp Ile Ala Ile Ser Glu Glu Glu Glu Met Val Tyr Glu His 
             900                905                910
Glu Lys Ser Lys Leu His Lys Asn Gly Tyr Glu Arg Lys Ser Ser Ala 
         915                920                925
Gly Gln Val Ser Arg Glu Ser Arg Asn Gly Lys Ile Trp Arg Asn Ile 
     930                935                940
Arg Lys Thr Cys Cys Lys Ile Val Glu Asn Ser Trp Phe Glu Cys Phe 
 945                950                955                960
Ile Gly Leu Val Thr Leu Leu Cys Thr Gly Thr Leu Ala Leu Glu Asp 
                 965                970                975
Ile Tyr Ile His Gln Arg Lys Thr Ile Lys Ile Phe Leu Glu Tyr Gly 
             980                985                990
Asp Met Ile Phe Ala Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys Trp 
         995                1000                1005
Val Ala Tyr Gly Phe Lys Ala Tyr Phe Ser Asn Asn Trp Tyr Lys Leu 
     1010                1015                1020
Asp Phe Met Val Val Ile Val Leu Cys Leu Ser Leu Lys Gly Lys Thr 
 1025                1030                1035                1040
Arg Glu Asp Leu Asn Pro Leu Pro Ser Ile Lys Phe Leu Arg Ala Leu 
                 1045                1050                1055
Arg Val Leu Ser Gln Phe Glu Arg Met Lys Val Val Leu Arg Ala Leu 
             1060                1065                1070
Ile Lys Thr Thr Leu Pro Ala Val Ser Val Phe Leu Val Cys Leu Met 
         1075                1080                1085
Ile Trp Leu Leu Phe Ser Val Met Gly Val Phe Leu Phe Ala Gly Lys 
     1090                1095                1100
Phe Tyr Glu Cys Ile Asp Pro Thr Arg Gly Glu Arg Phe Ser Val Phe 
 1105                1110                1115                1120
Glu Val Met Asn Lys Ser Gln Cys Glu Asn Leu Val Phe Asn Glu Ser 
                 1125                1130                1135
Met Pro Trp Glu Asn Ala Lys Leu Asn Phe Asp Asn Val Gly Asn Gly 
             1140                1145                1150
Phe Leu Ser Leu Phe Gln Val Ala Thr Phe Asn Gly Trp Ile Ser Ile 
         1155                1160                1165
Met Asn Ser Ala Ile Asp Ser Val Gly Val Tyr Met Gln Pro Ser Phe 
     1170                1175                1180
Glu His Ser Leu His Met Tyr Thr Tyr Phe Ile Ile Phe Val Val Phe 
 1185                1190                1195                1200
Gly Leu Phe Leu Pro Leu Cys Met Leu Ile Gly Val Ile Ile Arg Asn 
                 1205                1210                1215
Phe Asn Lys Gln Lys Ile Lys Gln Gly Gly Ser Asn Ile Phe Ile Thr 
             1220                1225                1230
Val Lys Gln Lys Lys Gln Tyr Arg Ala Leu Lys Lys Leu Leu Tyr Ala 
         1235                1240                1245
Asp Ser Gln Lys Pro Ala Ala Arg Pro Arg Asn Lys Phe Gln Gly Phe 
     1250                1255                1260
Ile Cys Asp Val Val Thr His Arg Val Phe Asn Val Val Val Val Leu 
 1265                1270                1275                1280
Leu Ile Cys Phe Gln Ala Thr Thr Ile Met Ile Gln Asn Asp Glu Gln 
                 1285                1290                1295
Ser Pro Gln Ile Glu Thr Ala Val Phe Trp Met Asn Ser Leu Phe Thr 
             1300                1305                1310
Met Leu Phe Thr Leu Glu Cys Ile Leu Lys Leu Thr Ala Phe Arg Cys 
         1315                1320                1325
His Tyr Phe Thr Ser Ala Trp Asn Val His Asp Phe Met Val Val Val 
     1330                1335                1340
Phe Ser Ile Thr Gly Leu Leu Leu Pro Leu Ser Ile Gly Gln Tyr Phe 
 1345                1350                1355                1360
Val Pro Pro Ser Leu Val Gln Leu Leu Leu Leu Ser Arg Ile Ile His 
                 1365                1370                1375
Val Leu Arg Pro Gly Lys Gly Pro Lys Val Phe His Asp Leu Met Leu 
             1380                1385                1390
Pro Leu Met Leu Ser Leu Pro Ala Leu Leu Asn Ile Gly Leu Leu Ile 
         1395                1400                1405
Phe Leu Val Met Phe Ile Tyr Ala Ile Phe Gly Met Tyr Asn Phe Ala 
     1410                1415                1420
Tyr Val Lys Lys Glu Ala Gly Ile Asn Asp Val Ser Asn Phe Glu Thr 
 1425                1430                1435                1440
Phe Gly Ser Ser Met Leu Cys Leu Phe Gln Val Thr Thr Phe Ser Gly 
                 1445                1450                1455
Trp Asp Gly Met Leu Asp Ala Ile Phe Asn Ser Gln Trp Ser Asp Cys 
             1460                1465                1470
Asp Pro Asp Lys Ile Asn Pro Gly Thr Gln Val Arg Gly Asp Cys Gly 
         1475                1480                1485
Ser Pro Ser Val Gly Ile Phe Tyr Phe Val Ser Tyr Ile Leu Ile Ser 
     1490                1495                1500
Trp Leu Ile Ile Val Asn Met Tyr Val Val Leu Ile Met Glu Phe Leu 
 1505                1510                1515                1520
Ser Ile Pro Ser Lys Arg Lys Asn Arg Thr Leu Ser Glu Asp Asp Phe 
                 1525                1530                1535
Arg Arg Phe Phe Lys Val Trp Asn Arg Phe Asp Pro Asp Arg Thr Gln 
             1540                1545                1550
Tyr Ile Asp Ser Thr Lys Leu Ser Asp Phe Ala Ala Ala Leu Asp Pro 
         1555                1560                1565
Pro Leu Phe Met Ala Lys Pro Asn Lys Gly Gln Leu Val Ala Met Asp 
     1570                1575                1580
Leu Pro Met Ala Ala Gly Asp Arg Ile His Cys Leu Asp Ile Leu Leu 
 1585                1590                1595                1600
Ala Phe Thr Lys Arg Val Met Gly Lys Asp Glu Arg Val Glu Lys Ile 
                 1605                1610                1615
Leu Ser Glu Ile Glu Ser Gly Phe Met Leu Ala Asn Pro Phe Lys Ile 
             1620                1625                1630
Thr Tyr Glu Pro Ile Thr Thr Thr Leu Lys Arg Lys Gln Glu Ala Val 
         1635                1640                1645
Ser Ala Thr Ile Ile Gln Arg Ala Tyr Lys Ser Tyr Arg Leu Arg Gln 
     1650                1655                1660
Ser Asp Lys Lys Ile Gln Asp Ile Pro Glu Ile Asp Asp Gly Arg Glu 
 1665                1670                1675                1680
Asp Pro Asn Ser Lys Gly Val His Ser Gly Gln Ile Glu Glu Lys Ala 
                 1685                1690                1695
Ser Ile Gln Thr Gln Ile 
             1700



<210> 6309
<211> 5389
<212> DNA
<213> Homo sapiens
<308> M91556
<400> 6309

gcggccgcg  aagtcctcc  ccatgtgaa  gccaacatg  ccaggtcat  agagctgag  60
gaaaactag  gcccaaaga  atgaaaaga  tgtggatct  ctggagaag  gctgttgtt  120
aacaggtac  aaattggaa  tgttggctt  accagaacc  aagggcctt  ttcccttca  180
taaagagtc  tttgaactt  taaaacagc  tattgctaa  acacataat  aagaccatg  240
agaagaaga  ttaaagcca  atcctgatt  ggaagttgg  aaaaagctt  catttattt  300
tggaaacct  tctcaagga  tggtgtcag  gcccttgga  gatgtggac  catattact  360
caagaaaaa  aatactttc  tagtattaa  taaaaatag  acaatcttc  gattcaatg  420
ggcttccat  ttgtgtaca  tgtctcctt  caattgtat  agaagaaca  ctatcaagg  480
tttggtaca  ccctttttc  aactgttta  tctaattag  gtcctgatt  attgcgtat  540
catgtccct  actaatttg  caaaatgga  accagtatt  gagaatact  tgcttggaa  600
ttacacatt  gaaatactt  taaaactct  tgcaagagg  gtctgggca  gatcatttt  660
cttcctcgg  gatccatgg  actggctcg  tttcagcgt  actgtgttt  aggttatta  720
aagatactc  cctctggac  tcattccaa  gcttcaaac  gcaagaact  tgagaattt  780
aaaaattat  cctttaaat  aaggtctga  atcccttgt  ggggtcctg  tccactgct  840
gaagcagct  attggtgtc  ttatcctaa  tctgttttt  ctgagcata  tttctctaa  900
tgggatggg  ctcttcatg  gcaacttga  acacaaatg  tttcgatgg  cccaagaga  960
tgaaaatga  accctgcac  acagaactg  aaacccata  tatattcga  aaacagaaa  1020
cttttatta  ttggaagga  aaagatatg  tctcctttg  ggcaacagg  cagatgctg  1080
tcagtgtcc  gaaggatat  tgtgtgtaa  agctggcat  aatcctgat  aaggcttca  1140
aaattttga  agttttggc  gggccttat  tgccctatt  cggttaatg  ctcaggatt  1200
ccctgaagt  ctttatcac  tgatacttt  tgcttctgg  aaggtctac  tgatatttt  1260
tgtggtggt  agttttttg  tttcctttt  tatggcaag  ttgttctta  gcatacttg  1320
catggccta  gaagaagaa  agcagagag  tggtgaaat  tctaagaag  ttgaaccaa  1380
atttcaaca  actggaaaa  aacttcaag  aggaaatga  acagatgag  ccaagacca  1440
acaaataga  atgaagaaa  ggtcaccaa  ttccacaga  acatcattg  atgtgttgg  1500
agatgctac  ctcagacat  aggaagaac  tgaaaaatc  aagaagata  gcccattat  1560
ctggtataa  tttgctaaa  ctttcttga  ctggaattg  tctccctgt  ggttaaaat  1620
gaaagagtt  gtccatagg  ttataatgg  accatttac  gatcttttc  ttatcatat  1680
cataatttt  aacgtatgt  ttctgacct  ggagcatta  ccaatgagt  aacaaacta  1740
cactcttct  aacattgga  acctggttt  cattggaat  ttcacagca  aaatgattt  1800
taaaataat  gcaatgcat  catatgggt  tttccaagt  ggttggaac  tttttgata  1860
catgatagt  ttccatggt  taatagaac  ttgtctagc  aatgttgca  gaatggctc  1920
tcttcgatt  ttcaggatg  taagaattt  caagttggg  aagtattgg  caacattcc  1980
gattttgat  tggtctctt  gtaactcat  ggtggccct  aaagacttg  tcctgttgt  2040
gttcacatt  atcttcttt  ctgctgcat  cggcatgaa  ctgtttggt  agaattatg  2100
agaatttgt  tgccacata  acaaagact  tcaactccc  cgctggcac  tgcatgact  2160
tttccactc  ttcctgaat  tgttccgaa  tctctgtgg  gagtgggta  agaccttgt  2220
ggactgtat  gaggttgca  gccaatcct  gtgtattcc  ttttacctg  tggtcattt  2280
aattggaaa  ttactggta  tttacctgt  tctggcatt  gtgagctca  ttagttcat  2340
caaggatgt  acagctgaa  agaataatg  agcaaaaaa  ctccagctt  cagtggcaa  2400
aattaaaaa  ggaataaac  atgtgcttc  taaaatact  tgcaaaaca  aaaatgtcc  2460
aaaggacac  atggaccat  taaatgagg  atatgttaa  gaagatatt  ctgaccata  2520
cctttctga  ttgagcaac  cccaagatt  tctcaaaga  aaggaaaaa  gcagtggca  2580
agagaaaaa  gctactgaa  atgagagcc  atcacttat  cccagtcct  gtgtctcag  2640
aactgtacc  attgcttca  gagaatctg  tatagaaaa  ctggataat  aggagattc  2700
gagtaagtc  ggtgatgga  gcagcaaag  gaaaataaa  caatctagc  catctgaat  2760
cagtactgt  gatattgct  tctctgaag  agaagaaat  ttctatgga  gtgaaagat  2820
aaagcatct  aaaaatggt  gcagacgcg  atcttcact  ggtcaaatc  gtggagcat  2880
caagaaagg  aaaatctgg  agaacatca  gaaaacctg  tgcaagatt  tagagaaca  2940
ttggtttaa  tgttttatt  ggcttgtta  tctgctcag  actggcact  tggcttttg  3000
agatatata  attgatcag  gaaagacaa  taaaatttt  ttagaatat  ctgacatga  3060
ctttactta  atcttcatt  tggaaatgc  tctaaaatg  atggcatat  gttttaagg  3120
ctatttctc  aatggctgg  acaggctgg  cttcgtggt  gttattgtg  tttgtctta  3180
cttaatagg  aaaactcgg  aagaactaa  acctcttat  tccatgaaa  tccttcggc  3240
cctcagagt  ctatctcaa  ttgaaagaa  gaaggtggt  gtgagagct  tgatcaaaa  3300
aaccttacc  actttgaat  tgtttcttg  ctgcctgat  atctggctg  tttttagta  3360
catgggagt  gacttattt  ctggcagat  ctatgaatg  attgaccca  caagtggag  3420
aaggtttcc  tcatctgaa  tcatgaata  gagtcggtg  gaaagcctt  tgtttaacg  3480
atccatgct  tgggaaaat  caaaaatga  ctttgataa  gttggaaat  gtttccttt  3540
tctgcttca  gtagcaaca  ttaatggat  gatcactat  atgaattca  caattgatt  3600
tgttgctgt  aatatacag  ctcattttg  agtcaacat  tacatgtat  gttacttta  3660
caactttat  atatttgga  tatttctcc  tctgagtat  ctgattact  ttattattg  3720
taatttcaa  aagcataaa  taaagctgg  aggctcaaa  atctttata  cggttaaac  3780
gagaaaaca  taccgcagg  tgaagaagc  aatgtatga  gattctcaa  gaccagtac  3840
tcgcccatt  aacaagctc  aaggattca  ctttgatgt  gtaacaagc  aagctttta  3900
tgtcattgt  atggttctt  tatgtttcc  agcaatagc  atgatgata  acactgatg  3960
tcagagtct  caaatgtcc  ttgctctct  ctggattaa  tcaattttt  ttatgctat  4020
tactatgga  tgtatactg  agctcatcg  tttccgttg  ttttatttc  ccattgcgt  4080
gaacatttt  gattttatg  tggttattt  ctccatcac  ggactatgt  tgcctatga  4140
agtaggatc  taccttgtg  ctccttcac  tgtgcaact  atacttctc  cacggatca  4200
tcacatgct  cgtcttgga  aaggaccaa  ggtgtttca  aatctgatg  ttcctttga  4260
gctgtccct  ccagcatta  tgaacatca  tcttctcat  ttcctggtc  tgttcatct  4320
tgccgtatt  ggaatgtat  attttgcct  tgttaaaaa  gaagctgga  ttaatgatg  4380
gtctaattt  gaaaccttt  gcaacagta  gctctgtct  tttcaagtt  caatatttg  4440
tggttggga  gggatgctt  atgcaattt  caacagtaa  tggtctgac  gtgatcctg  4500
taaaattaa  cctgggact  aagttagag  agattgtgg  aacccctct  ttgggattt  4560
ttattttgt  agttatatc  tcatatcat  gctgatcat  gtaaatatg  acattgttg  4620
tgtcatgga  tttttaaat  ttgcttcta  gaagaaaaa  aagaccttg  gtgaagatg  4680
ttttaggaa  ttctttcag  tatggaaaa  gtttgatcc  gataggacc  agtacatag  4740
ctctagcaa  ctttcagat  ttgcagctg  tcttgatcc  cctcttttc  tggcaaaac  4800
aaacaaggg  cagctcatt  ctttggacc  ccccatggc  gttggggac  gaattcatt  4860
cctcgatat  ttacttgct  ttacaaaga  agttatggg  caagatgtg  ggatggaga  4920
agttgtttc  gaaatagaa  cagggtttt  gttagccaa  ccttttaag  tcacatgtg  4980
gccaattac  actactttg  aacgaaaac  agaggcagt  tcagcaacc  tcattcaac  5040
tgcttataa  aattaccgc  tgaggcgaa  tgacaaaaa  acatcagat  ttcatatga  5100
agatggtga  agagatgtt  atgctacta  agaaggtgc  tattttgac  aagctaagg  5160
aaagtcacc  attcaaagc  agatctaat  ccacttacc  cctcttttc  tatttcttc  5220
catatctga  aaatgttga  agcctaagc  aggaataaa  gaaaagtag  gataataat  5280
agttcttta  aaccgatgg  aattaagct  gtattcaca  gacttcatg  caaattcac  5340
ttttagcat  atatctaac  aatcaagag  atccttaat  ttgctgcag  5389



<210> 6310
<211> 1682
<212> PRT
<213> Homo sapiens
<308> Q01118
<400> 6310

Met Leu Ala Ser Pro Glu Pro Lys Gly Leu Val Pro Phe Thr Lys Glu 
  1               5                  10                  15
Ser Phe Glu Leu Ile Lys Gln His Ile Ala Lys Thr His Asn Glu Asp 
             20                  25                  30
His Glu Glu Glu Asp Leu Lys Pro Asn Pro Asp Leu Glu Val Gly Lys 
         35                  40                  45
Lys Leu Pro Phe Ile Tyr Gly Asn Leu Ser Gln Gly Met Val Ser Glu 
     50                  55                  60
Pro Leu Glu Asp Val Asp Pro Tyr Tyr Tyr Lys Lys Lys Asn Thr Phe 
 65                  70                  75                  80
Ile Val Leu Asn Lys Asn Arg Thr Ile Phe Arg Phe Asn Ala Ala Ser 
                 85                  90                  95
Ile Leu Cys Thr Leu Ser Pro Phe Asn Cys Ile Arg Arg Thr Thr Ile 
             100                105                110
Lys Val Leu Val His Pro Phe Phe Gln Leu Phe Ile Leu Ile Ser Val 
         115                120                125
Leu Ile Asp Cys Val Phe Met Ser Leu Thr Asn Leu Pro Lys Trp Arg 
     130                135                140
Pro Val Leu Glu Asn Thr Leu Leu Gly Ile Tyr Thr Phe Glu Ile Leu 
 145                150                155                160
Val Lys Leu Phe Ala Arg Gly Val Trp Ala Gly Ser Phe Ser Phe Leu 
                 165                170                175
Gly Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Thr Val Phe Glu Val 
             180                185                190
Ile Ile Arg Tyr Ser Pro Leu Asp Phe Ile Pro Thr Leu Gln Thr Ala 
         195                200                205
Arg Thr Leu Arg Ile Leu Lys Ile Ile Pro Leu Asn Gln Gly Leu Lys 
     210                215                220
Ser Leu Val Gly Val Leu Ile His Cys Leu Lys Gln Leu Ile Gly Val 
 225                230                235                240
Ile Ile Leu Thr Leu Phe Phe Leu Ser Ile Phe Ser Leu Ile Gly Met 
                 245                250                255
Gly Leu Phe Met Gly Asn Leu Lys His Lys Cys Phe Arg Trp Pro Gln 
             260                265                270
Glu Asn Glu Asn Glu Thr Leu His Asn Arg Thr Gly Asn Pro Tyr Tyr 
         275                280                285
Ile Arg Glu Thr Glu Asn Phe Tyr Tyr Leu Glu Gly Glu Arg Tyr Ala 
     290                295                300
Leu Leu Cys Gly Asn Arg Thr Asp Ala Gly Gln Cys Pro Glu Gly Tyr 
 305                310                315                320
Val Cys Val Lys Ala Gly Ile Asn Pro Asp Gln Gly Phe Thr Asn Phe 
                 325                330                335
Asp Ser Phe Gly Trp Ala Leu Phe Ala Leu Phe Arg Leu Met Ala Gln 
             340                345                350
Asp Tyr Pro Glu Val Leu Tyr His Leu Ile Leu Tyr Ala Ser Gly Lys 
         355                360                365
Val Tyr Met Ile Phe Phe Val Val Val Ser Phe Leu Phe Ser Phe Tyr 
     370                375                380
Met Ala Ser Leu Phe Leu Gly Ile Leu Ala Met Ala Tyr Glu Glu Glu 
 385                390                395                400
Lys Gln Arg Val Gly Glu Ile Ser Lys Lys Ile Glu Pro Lys Phe Gln 
                 405                410                415
Gln Thr Gly Lys Glu Leu Gln Glu Gly Asn Glu Thr Asp Glu Ala Lys 
             420                425                430
Thr Ile Gln Ile Glu Met Lys Lys Arg Ser Pro Ile Ser Thr Asp Thr 
         435                440                445
Ser Leu Asp Val Leu Glu Asp Ala Thr Leu Arg His Lys Glu Glu Leu 
     450                455                460
Glu Lys Ser Lys Lys Ile Cys Pro Leu Tyr Trp Tyr Lys Phe Ala Lys 
 465                470                475                480
Thr Phe Leu Ile Trp Asn Cys Ser Pro Cys Trp Leu Lys Leu Lys Glu 
                 485                490                495
Phe Val His Arg Ile Ile Met Ala Pro Phe Thr Asp Leu Phe Leu Ile 
             500                505                510
Ile Cys Ile Ile Leu Asn Val Cys Phe Leu Thr Leu Glu His Tyr Pro 
         515                520                525
Met Ser Lys Gln Thr Asn Thr Leu Leu Asn Ile Gly Asn Leu Val Phe 
     530                535                540
Ile Gly Ile Phe Thr Ala Glu Met Ile Phe Lys Ile Ile Ala Met His 
 545                550                555                560
Pro Tyr Gly Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Met Ile 
                 565                570                575
Val Phe His Gly Leu Ile Glu Leu Cys Leu Ala Asn Val Ala Gly Met 
             580                585                590
Ala Leu Leu Arg Leu Phe Arg Met Leu Arg Ile Phe Lys Leu Gly Lys 
         595                600                605
Tyr Trp Pro Thr Phe Gln Ile Leu Met Trp Ser Leu Ser Asn Ser Trp 
     610                615                620
Val Ala Leu Lys Asp Leu Val Leu Leu Leu Phe Thr Phe Ile Phe Phe 
 625                630                635                640
Ser Ala Ala Phe Gly Met Lys Leu Phe Gly Lys Asn Tyr Glu Glu Phe 
                 645                650                655
Val Cys His Ile Asp Lys Asp Cys Gln Leu Pro Arg Trp His Met His 
             660                665                670
Asp Phe Phe His Ser Phe Leu Asn Val Phe Arg Ile Leu Cys Gly Glu 
         675                680                685
Trp Val Glu Thr Leu Trp Asp Cys Met Glu Val Ala Gly Gln Ser Trp 
     690                695                700
Cys Ile Pro Phe Tyr Leu Met Val Ile Leu Ile Gly Asn Leu Leu Val 
 705                710                715                720
Leu Tyr Leu Phe Leu Ala Leu Val Ser Ser Phe Ser Ser Cys Lys Asp 
                 725                730                735
Val Thr Ala Glu Glu Asn Asn Glu Ala Lys Asn Leu Gln Leu Ala Val 
             740                745                750
Ala Arg Ile Lys Lys Gly Ile Asn Tyr Val Leu Leu Lys Ile Leu Cys 
         755                760                765
Lys Thr Gln Asn Val Pro Lys Asp Thr Met Asp His Val Asn Glu Val 
     770                775                780
Tyr Val Lys Glu Asp Ile Ser Asp His Thr Leu Ser Glu Leu Ser Asn 
 785                790                795                800
Thr Gln Asp Phe Leu Lys Asp Lys Glu Lys Ser Ser Gly Thr Glu Lys 
                 805                810                815
Asn Ala Thr Glu Asn Glu Ser Gln Ser Leu Ile Pro Ser Pro Ser Val 
             820                825                830
Ser Glu Thr Val Pro Ile Ala Ser Gly Glu Ser Asp Ile Glu Asn Leu 
         835                840                845
Asp Asn Lys Glu Ile Gln Ser Lys Ser Gly Asp Gly Gly Ser Lys Glu 
     850                855                860
Lys Ile Lys Gln Ser Ser Ser Ser Glu Cys Ser Thr Val Asp Ile Ala 
 865                870                875                880
Ile Ser Glu Glu Glu Glu Met Phe Tyr Gly Gly Glu Arg Ser Lys His 
                 885                890                895
Leu Lys Asn Gly Cys Arg Arg Gly Ser Ser Leu Gly Gln Ile Ser Gly 
             900                905                910
Ala Ser Lys Lys Gly Lys Ile Trp Gln Asn Ile Arg Lys Thr Cys Cys 
         915                920                925
Lys Ile Val Glu Asn Asn Trp Phe Lys Cys Phe Ile Gly Leu Val Thr 
     930                935                940
Leu Leu Ser Thr Gly Thr Leu Ala Phe Glu Asp Ile Tyr Ile Asp Gln 
 945                950                955                960
Arg Lys Thr Ile Lys Ile Leu Leu Glu Tyr Ala Asp Met Ile Phe Thr 
                 965                970                975
Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Met Ala Tyr Gly Phe 
             980                985                990
Lys Ala Tyr Phe Ser Asn Gly Trp Tyr Arg Leu Asp Phe Val Val Val 
         995                1000                1005
Ile Val Phe Cys Leu Ser Leu Ile Gly Lys Thr Arg Glu Glu Leu Lys 
     1010                1015                1020
Pro Leu Ile Ser Met Lys Phe Leu Arg Pro Leu Arg Val Leu Ser Gln 
 1025                1030                1035                1040
Phe Glu Arg Met Lys Val Val Val Arg Ala Leu Ile Lys Thr Thr Leu 
                 1045                1050                1055
Pro Thr Leu Asn Val Phe Leu Val Cys Leu Met Ile Trp Leu Ile Phe 
             1060                1065                1070
Ser Ile Met Gly Val Asp Leu Phe Ala Gly Arg Phe Tyr Glu Cys Ile 
         1075                1080                1085
Asp Pro Thr Ser Gly Glu Arg Phe Pro Ser Ser Glu Val Met Asn Lys 
     1090                1095                1100
Ser Arg Cys Glu Ser Leu Leu Phe Asn Glu Ser Met Leu Trp Glu Asn 
 1105                1110                1115                1120
Ala Lys Met Asn Phe Asp Asn Val Gly Asn Gly Phe Leu Ser Leu Leu 
                 1125                1130                1135
Gln Val Ala Thr Phe Asn Gly Trp Ile Thr Ile Met Asn Ser Ala Ile 
             1140                1145                1150
Asp Ser Val Ala Val Asn Ile Gln Pro His Phe Glu Val Asn Ile Tyr 
         1155                1160                1165
Met Tyr Cys Tyr Phe Ile Asn Phe Ile Ile Phe Gly Val Phe Leu Pro 
     1170                1175                1180
Leu Ser Met Leu Ile Thr Val Ile Ile Asp Asn Phe Asn Lys His Lys 
 1185                1190                1195                1200
Ile Lys Leu Gly Gly Ser Asn Ile Phe Ile Thr Val Lys Gln Arg Lys 
                 1205                1210                1215
Gln Tyr Arg Arg Leu Lys Lys Leu Met Tyr Glu Asp Ser Gln Arg Pro 
             1220                1225                1230
Val Pro Arg Pro Leu Asn Lys Leu Gln Gly Phe Ile Phe Asp Val Val 
         1235                1240                1245
Thr Ser Gln Ala Phe Asn Val Ile Val Met Val Leu Ile Cys Phe Gln 
     1250                1255                1260
Ala Ile Ala Met Met Ile Asp Thr Asp Val Gln Ser Leu Gln Met Ser 
 1265                1270                1275                1280
Ile Ala Leu Tyr Trp Ile Asn Ser Ile Phe Val Met Leu Tyr Thr Met 
                 1285                1290                1295
Glu Cys Ile Leu Lys Leu Ile Ala Phe Arg Cys Phe Tyr Phe Thr Ile 
             1300                1305                1310
Ala Trp Asn Ile Phe Asp Phe Met Val Val Ile Phe Ser Ile Thr Gly 
         1315                1320                1325
Leu Cys Leu Pro Met Thr Val Gly Ser Tyr Leu Val Pro Pro Ser Leu 
     1330                1335                1340
Val Gln Leu Ile Leu Leu Ser Arg Ile Ile His Met Leu Arg Leu Gly 
 1345                1350                1355                1360
Lys Gly Pro Lys Val Phe His Asn Leu Met Leu Pro Leu Met Leu Ser 
                 1365                1370                1375
Leu Pro Ala Leu Leu Asn Ile Ile Leu Leu Ile Phe Leu Val Met Phe 
             1380                1385                1390
Ile Tyr Ala Val Phe Gly Met Tyr Asn Phe Ala Tyr Val Lys Lys Glu 
         1395                1400                1405
Ala Gly Ile Asn Asp Val Ser Asn Phe Glu Thr Phe Gly Asn Ser Met 
     1410                1415                1420
Leu Cys Leu Phe Gln Val Ala Ile Phe Ala Gly Trp Asp Gly Met Leu 
 1425                1430                1435                1440
Asp Ala Ile Phe Asn Ser Lys Trp Ser Asp Cys Asp Pro Asp Lys Ile 
                 1445                1450                1455
Asn Pro Gly Thr Gln Val Arg Gly Asp Cys Gly Asn Pro Ser Val Gly 
             1460                1465                1470
Ile Phe Tyr Phe Val Ser Tyr Ile Leu Ile Ser Trp Leu Ile Ile Val 
         1475                1480                1485
Asn Met Tyr Ile Val Val Val Met Glu Phe Leu Asn Ile Ala Ser Lys 
     1490                1495                1500
Lys Lys Asn Lys Thr Leu Ser Glu Asp Asp Phe Arg Lys Phe Phe Gln 
 1505                1510                1515                1520
Val Trp Lys Arg Phe Asp Pro Asp Arg Thr Gln Tyr Ile Asp Ser Ser 
                 1525                1530                1535
Lys Leu Ser Asp Phe Ala Ala Ala Leu Asp Pro Pro Leu Phe Met Ala 
             1540                1545                1550
Lys Pro Asn Lys Gly Gln Leu Ile Ala Leu Asp Leu Pro Met Ala Val 
         1555                1560                1565
Gly Asp Arg Ile His Cys Leu Asp Ile Leu Leu Ala Phe Thr Lys Arg 
     1570                1575                1580
Val Met Gly Gln Asp Val Arg Met Glu Lys Val Val Ser Glu Ile Glu 
 1585                1590                1595                1600
Ser Gly Phe Leu Leu Ala Asn Pro Phe Lys Ile Thr Cys Glu Pro Ile 
                 1605                1610                1615
Thr Thr Thr Leu Lys Arg Lys Gln Glu Ala Val Ser Ala Thr Ile Ile 
             1620                1625                1630
Gln Arg Ala Tyr Lys Asn Tyr Arg Leu Arg Arg Asn Asp Lys Asn Thr 
         1635                1640                1645
Ser Asp Ile His Met Ile Asp Gly Asp Arg Asp Val His Ala Thr Lys 
     1650                1655                1660
Glu Gly Ala Tyr Phe Asp Lys Ala Lys Glu Lys Ser Pro Ile Gln Ser 
 1665                1670                1675                1680
Gln Ile 
                 1685



<210> 6311
<211> 454
<212> DNA
<213> Rattus norvegicus
<308> AA925300
<400> 6311

ttttttttt  tttttttgc  tcattcatc  ttggtaaga  aggactgac  cagcatacc  60
ggaagctta  tggggcagc  caaacctct  cctcctgtt  ctgggggac  ctgggcttt  120
cctcaggct  gtgtgggct  atgcagccc  gagattctc  ggtggtctc  aaacattgg  180
agagaaaca  agtaacact  tggatgaag  aacactatt  atacccttg  gtaggtcct  240
tgcctagtc  ctcttgact  cagtgctgt  tgcagtgtt  ggacacatc  gagggcagg  300
aggacccat  gcagtctta  atactggtc  cagcccttc  tgccacact  agcttagga  360
gtcaaagct  ttgggtctt  caggctgga  ctcccagtc  tgatgccag  tcctggctt  420
gagtcccag  ggcagatgg  gcaccctcg  gccg  454



<210> 6312
<211> 626
<212> PRT
<213> Rattus norvegicus
<308> AAB03535
<400> 6312

Met Asp Glu Gln Glu Ala Leu Asp Ser Ile Met Lys Asp Leu Val Ala 
  1               5                  10                  15
Leu Gln Met Ser Arg Arg Thr Arg Leu Ser Gly Tyr Glu Thr Met Lys 
             20                  25                  30
Asn Lys Asp Thr Gly His Pro Asn Arg Gln Ser Asp Val Arg Ile Lys 
         35                  40                  45
Phe Glu His Asn Gly Glu Arg Arg Ile Ile Ala Phe Ser Arg Pro Val 
     50                  55                  60
Arg Tyr Glu Asp Val Glu His Lys Val Thr Thr Val Phe Gly Gln Pro 
 65                  70                  75                  80
Leu Asp Leu His Tyr Met Asn Asn Glu Leu Ser Ile Leu Leu Lys Asn 
                 85                  90                  95
Gln Asp Asp Leu Asp Lys Ala Ile Asp Ile Leu Asp Arg Ser Ser Ser 
             100                105                110
Met Lys Ser Leu Arg Ile Leu Leu Leu Ser Gln Asp Arg Asn His Thr 
         115                120                125
Ser Ser Ser Pro His Ser Gly Val Ser Arg Gln Val Arg Ile Lys Pro 
     130                135                140
Ser Gln Ser Ala Gly Asp Ile Asn Thr Ile Tyr Gln Ala Pro Glu Pro 
 145                150                155                160
Arg Ser Arg His Leu Ser Val Ser Ser Gln Asn Pro Gly Arg Ser Ser 
                 165                170                175
Pro Pro Pro Gly Tyr Val Pro Glu Arg Gln Gln His Ile Ala Arg Gln 
             180                185                190
Gly Ser Tyr Thr Ser Ile Asn Ser Glu Gly Glu Phe Ile Pro Glu Thr 
         195                200                205
Ser Glu Gln Cys Met Leu Asp Pro Leu Ser Ser Ala Glu Asn Ser Leu 
     210                215                220
Ser Gly Ser Cys Gln Ser Leu Asp Arg Ser Ala Asp Ser Pro Ser Phe 
 225                230                235                240
Arg Lys Ser Gln Met Ser Arg Ala Arg Ser Phe Pro Asp Asn Arg Lys 
                 245                250                255
Glu Cys Ser Asp Arg Glu Thr Gln Leu Tyr Asp Lys Gly Val Lys Gly 
             260                265                270
Gly Thr Tyr Pro Arg Arg Tyr His Val Ser Val His His Lys Asp Tyr 
         275                280                285
Asn Asp Gly Arg Arg Thr Phe Pro Arg Ile Arg Arg His Gln Gly Asn 
     290                295                300
Leu Phe Thr Leu Val Pro Ser Ser Arg Ser Leu Ser Thr Asn Gly Glu 
 305                310                315                320
Asn Met Gly Val Ala Val Gln Tyr Leu Asp Pro Arg Gly Arg Leu Arg 
                 325                330                335
Ser Ala Asp Ser Glu Asn Ala Leu Thr Val Gln Glu Arg Asn Val Pro 
             340                345                350
Thr Lys Ser Pro Ser Ala Pro Ile Asn Trp Arg Arg Gly Lys Leu Leu 
         355                360                365
Gly Gln Gly Ala Phe Gly Arg Val Tyr Leu Cys Tyr Asp Val Asp Thr 
     370                375                380
Gly Arg Glu Leu Ala Ser Lys Gln Val Gln Phe Asp Pro Asp Ser Pro 
 385                390                395                400
Glu Thr Ser Lys Glu Val Ser Ala Leu Glu Cys Glu Ile Gln Leu Leu 
                 405                410                415
Lys Asn Leu Gln His Glu Arg Ile Val Gln Tyr Tyr Gly Cys Leu Arg 
             420                425                430
Asp Arg Ala Glu Lys Ile Leu Thr Ile Phe Met Glu Tyr Met Pro Gly 
         435                440                445
Gly Ser Val Lys Asp Gln Leu Lys Ala Tyr Gly Ala Leu Thr Glu Ser 
     450                455                460
Val Thr Arg Lys Tyr Thr Arg Gln Ile Leu Glu Gly Met Ser Tyr Leu 
 465                470                475                480
His Ser Asn Met Ile Val His Arg Asp Ile Lys Gly Ala Asn Ile Leu 
                 485                490                495
Arg Asp Ser Ala Gly Asn Val Lys Leu Gly Asp Phe Gly Ala Ser Lys 
             500                505                510
Arg Leu Gln Thr Ile Cys Met Ser Gly Thr Gly Ile Arg Ser Val Thr 
         515                520                525
Gly Thr Pro Tyr Trp Met Ser Pro Glu Val Ile Ser Gly Glu Gly Tyr 
     530                535                540
Gly Arg Lys Ala Asp Val Trp Ser Leu Gly Cys Thr Val Val Glu Met 
 545                550                555                560
Leu Thr Glu Lys Pro Pro Trp Ala Glu Tyr Glu Ala Met Ala Ala Ile 
                 565                570                575
Phe Lys Ile Ala Thr Gln Pro Thr Asn Pro Gln Leu Pro Ser His Ile 
             580                585                590
Ser Glu His Gly Arg Asp Phe Leu Arg Arg Ile Phe Val Glu Ala Arg 
         595                600                605
Gln Arg Pro Ser Ala Glu Glu Leu Leu Thr His His Phe Ala Gln Leu 
     610                615                620
Val Tyr 
 625



<210> 6313
<211> 536
<212> DNA
<213> Rattus norvegicus
<308> AA925473
<400> 6313

ttttttttt  tttttttca  acaggatgg  tttattcct  tgttttaaa  gatctttct  60
cagtagtgg  acaggaagc  gcagcaaag  ggggaagga  aaaacggtt  agaatatac  120
gcacttcct  ttgggttga  tttccggag  ctcgagggc  gctaggata  cctcatcaa  180
cacattctt  agacctctc  gtgtgaggg  ggaacactc  acatacttg  cagccttca  240
atcccgcgc  agcttttca  cagtctctg  agtaatagg  ttctgtttg  tcttggcaa  300
tttctcaat  gtagaaggg  catctctga  atcaatttg  gtcccgaca  gcaagaaag  360
agtctttgg  cagtggtga  ttatctcag  cacccactt  tctttcaca  tttcaaatg  420
ggatggaga  accactgag  aacatacta  aaaaacatc  gtctgtgga  aacttaacg  480
tcgtagtct  tcataatcc  cttgccctg  agtatcaaa  agtccaaga  tgtatg  536



<210> 6314
<211> 191
<212> PRT
<213> Rattus norvegicus
<308> AAF15538
<400> 6314

Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
  1               5                  10                  15
Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser Glu Tyr 
             20                  25                  30
Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile Gly Gly 
         35                  40                  45
Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu Asp Tyr 
     50                  55                  60
Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Val 
 65                  70                  75                  80
Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                 85                  90                  95
Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe Leu Leu 
             100                105                110
Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile Glu Lys 
         115                120                125
Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys 
     130                135                140
Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
 145                150                155                160
Thr Gln Arg Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                 165                170                175
Leu Glu Pro Pro Glu Thr Gln Pro Lys Arg Lys Cys Cys Ile Phe 
             180                185                190



<210> 6315
<211> 488
<212> DNA
<213> Homo sapiens
<308> BG180991
<400> 6315

agaaaagtg  gtgcctgag  taactcacc  ctgtccaaa  actcctttc  tgcttgttg  60
gactcaaat  gatctcaga  atgacccct  tactattga  aaacttacc  gcaggtaca  120
gcaccaacc  ctttgcaca  tgagcagca  gactcgcta  ttctctcca  ctactcaca  180
cagccaggg  ccctgggct  cccccaacc  cccccagca  agccccagc  cctacgtcc  240
ccccgaagg  tcagcagtc  gtctgagtc  tcaggcctc  agcagccgc  ccagataat  300
ccccggcac  gaagtcggg  cacaatcag  tttaaccaa  tggatgacg  ggggtggcc  360
caggagatg  ggagaggag  ctgaactac  acccctggc  cttgtgcac  ctgcatacg  420
ttcagaact  ctggatggt  accatctct  gagtgcagc  cttgctgca  tggacatga  480
caggaata  488



<210> 6316
<211> 536
<212> DNA
<213> Rattus norvegicus
<308> AA925473
<400> 6316

ttttttttt  tttttttca  acaggatgg  tttattcct  tgttttaaa  gatctttct  60
cagtagtgg  acaggaagc  gcagcaaag  ggggaagga  aaaacggtt  agaatatac  120
gcacttcct  ttgggttga  tttccggag  ctcgagggc  gctaggata  cctcatcaa  180
cacattctt  agacctctc  gtgtgaggg  ggaacactc  acatacttg  cagccttca  240
atcccgcgc  agcttttca  cagtctctg  agtaatagg  ttctgtttg  tcttggcaa  300
tttctcaat  gtagaaggg  catctctga  atcaatttg  gtcccgaca  gcaagaaag  360
agtctttgg  cagtggtga  ttatctcag  cacccactt  tctttcaca  tttcaaatg  420
ggatggaga  accactgag  aacatacta  aaaaacatc  gtctgtgga  aacttaacg  480
tcgtagtct  tcataatcc  cttgccctg  agtatcaaa  agtccaaga  tgtatg  536



<210> 6317
<211> 191
<212> PRT
<213> Rattus norvegicus
<308> AAF15538
<400> 6317

Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
  1               5                  10                  15
Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser Glu Tyr 
             20                  25                  30
Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile Gly Gly 
         35                  40                  45
Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu Asp Tyr 
     50                  55                  60
Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Val 
 65                  70                  75                  80
Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                 85                  90                  95
Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe Leu Leu 
             100                105                110
Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile Glu Lys 
         115                120                125
Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys 
     130                135                140
Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
 145                150                155                160
Thr Gln Arg Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                 165                170                175
Leu Glu Pro Pro Glu Thr Gln Pro Lys Arg Lys Cys Cys Ile Phe 
             180                185                190



<210> 6318
<211> 488
<212> DNA
<213> Homo sapiens
<308> BG180991
<400> 6318

agaaaagtg  gtgcctgag  taactcacc  ctgtccaaa  actcctttc  tgcttgttg  60
gactcaaat  gatctcaga  atgacccct  tactattga  aaacttacc  gcaggtaca  120
gcaccaacc  ctttgcaca  tgagcagca  gactcgcta  ttctctcca  ctactcaca  180
cagccaggg  ccctgggct  cccccaacc  cccccagca  agccccagc  cctacgtcc  240
ccccgaagg  tcagcagtc  gtctgagtc  tcaggcctc  agcagccgc  ccagataat  300
ccccggcac  gaagtcggg  cacaatcag  tttaaccaa  tggatgacg  ggggtggcc  360
caggagatg  ggagaggag  ctgaactac  acccctggc  cttgtgcac  ctgcatacg  420
ttcagaact  ctggatggt  accatctct  gagtgcagc  cttgctgca  tggacatga  480
caggaata  488



<210> 6319
<211> 432
<212> DNA
<213> Rattus norvegicus
<308> AA925506
<400> 6319

ttttttttt  tttttttaa  agtaaaaac  tatccatat  ttatttaat  taatcaggg  60
ttaggggaa  gtcagagat  aatctccca  tgaaggagt  cagaaaatg  ccacagtcc  120
cacattgag  gacttgggt  ctagttagt  aaaaaatag  ttgacccag  aagggggat  180
tggaggcac  tcacgtgtg  gatggagaa  cccatcggt  cttctcaat  acctcaaga  240
aattaaatc  gcacttctg  cctcacaac  atctgtgta  ctgggagaa  aacgaggag  300
caccaatga  cacatggat  tcaggcttc  gagacaaag  tacacactc  gccatacca  360
caagtgctt  ctttgtatg  agacccaaa  gcccgtttc  aaaatgggc  aactctctg  420
agaaagggc  tc  432



<210> 6320
<211> 69
<212> PRT
<213> Rattus norvegicus
<308> P43425
<400> 6320

Met Met Ser Gly Thr Asn Asn Val Ala Gln Ala Arg Lys Leu Val Glu 
  1               5                  10                  15
Gln Leu Arg Ile Glu Ala Gly Ile Glu Arg Ile Lys Val Ser Lys Ala 
             20                  25                  30
Ser Ser Glu Leu Met Ser Tyr Cys Glu Gln His Ala Arg Asn Asp Pro 
         35                  40                  45
Leu Leu Val Gly Val Pro Ala Ser Glu Asn Pro Phe Lys Asp Lys Lys 
     50                  55                  60
Pro Cys Ile Ile Leu 
 65



<210> 6321
<211> 992
<212> DNA
<213> Homo sapiens
<308> BC014466
<400> 6321

gcgggccgg  gcggagggt  cggctgcgc  gcggggctg  ggcggccgc  gggcccgag  60
gcagggagt  gagcttggt  tcgggatct  ggtgctgca  acggcgaga  ctcctgcac  120
gggtgtaca  caagctgtg  ttcctggga  aactaaaaa  gctctctgg  caacggggc  180
cagagctga  ggcagacaa  gtcagccac  aacaacata  cccaggccc  gaagctggt  240
gaacagcta  gcatagaag  cgggattga  cgcatcaag  tctccaaag  ggcgtctga  300
ctcatgagc  actgtgagc  acatgcccg  aacgacccc  tgctggtcg  agtccctgc  360
tcggagaac  cctttaagg  caagaaacc  tgtattatt  tataactgt  ttctcatat  420
ttctctctc  ctctctctc  ttctctctc  ctctctgtc  ctgtctctg  ctcaggcag  480
gcatcattc  gtaattagc  caaacaaaa  atctcaagt  cccaaaacc  ttaattcca  540
aagaaatcc  ccctctccc  gccaaaaaa  gcgttccca  cgcccggat  gggtagaat  600
gaccttgta  gtggagatg  attttcagg  ccgacccca  ggccctctc  gtttgggcc  660
aaagggatg  aggctttac  gccacttcc  gttcggaat  actgaaatc  cccagcgat  720
gggtaacaa  tttttaaaa  tctcgattg  cgtttcaat  gtggaccgg  gccgagggg  780
aaagggagg  gacttcgcc  ggtggcaat  gttccggga  aattggcca  tggtaaaaa  840
acttcatag  gtcactgga  tgctttgtg  tgtttttaa  tagaggtaa  attgagatg  900
ggggcggga  gtgacatca  gaagttttt  ggaaatatc  ctttattta  aaaattgtt  960
ctccatacg  ctaaaaaaa  aaaaaaaaa  aa  992



<210> 6322
<211> 68
<212> PRT
<213> Homo sapiens
<308> O60262
<400> 6322

Met Ser Ala Thr Asn Asn Ile Ala Gln Ala Arg Lys Leu Val Glu Gln 
  1               5                  10                  15
Leu Arg Ile Glu Ala Gly Ile Glu Arg Ile Lys Val Ser Lys Ala Ala 
             20                  25                  30
Ser Asp Leu Met Ser Tyr Cys Glu Gln His Ala Arg Asn Asp Pro Leu 
         35                  40                  45
Leu Val Gly Val Pro Ala Ser Glu Asn Pro Phe Lys Asp Lys Lys Pro 
     50                  55                  60
Cys Ile Ile Leu 
 65



<210> 6323
<211> 501
<212> DNA
<213> Rattus norvegicus
<308> AA925752
<400> 6323

ttttttttt  tttttttga  ggacttaac  aaatacaag  ttttattaa  aatataggc  60
tagtgacat  ttaatcttt  cgaaatatg  tgtggctta  tgcaatata  aaataaata  120
atatctgca  taagagaga  agcgcgcac  ccaccgttt  ttcaactac  gataggtgt  180
ttttataaa  acaagcatg  cttaagtct  cgttttgga  attggtttt  ccaaaaatg  240
agctagtgc  taatgtagg  tcatccact  cttattttc  attcttaga  ctgcaagca  300
agtatgaaa  cataaaagc  acaaacatc  ctactccaa  accaagtaa  accatctca  360
ccaggccca  gagctttat  ttcccggtc  cttgggttc  gaacatttc  gctttctca  420
cgccgatgg  cccagtctc  tttagccac  gtataggta  aatgtaagg  ctcttcaga  480
tcttcagtg  ttctatttt  c  501



<210> 6324
<211> 471
<212> PRT
<213> Rattus norvegicus
<308> Q07969
<400> 6324

Gly Cys Asp Arg Asn Cys Gly Leu Ile Thr Gly Ala Val Ile Gly Ala 
  1               5                  10                  15
Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu Leu 
             20                  25                  30
Ile Glu Lys Thr Ile Lys Arg Glu Val Val Leu Glu Glu Gly Thr Ile 
         35                  40                  45
Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Thr Val Tyr Arg Gln Phe 
     50                  55                  60
Trp Val Phe Asp Val Gln Asn Pro Glu Glu Val Ala Lys Asn Ser Ser 
 65                  70                  75                  80
Lys Ile Lys Val Ile Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg Tyr 
                 85                  90                  95
Leu Ala Lys Glu Asn Ile Thr Gln Asp Pro Lys Asp Ser Thr Val Ser 
             100                105                110
Phe Val Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val Gly 
         115                120                125
Thr Glu Asn Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala Ala 
     130                135                140
Pro His Ile Tyr Thr Asn Ser Phe Val Gln Gly Val Leu Asn Ser Leu 
 145                150                155                160
Ile Lys Lys Ser Lys Ser Ser Met Phe Gln Thr Arg Ser Leu Lys Glu 
                 165                170                175
Leu Leu Trp Gly Tyr Lys Asp Pro Phe Leu Ser Leu Val Pro Tyr Pro 
             180                185                190
Ile Ser Thr Thr Val Gly Val Phe Tyr Pro Tyr Asn Asn Thr Val Asp 
         195                200                205
Gly Val Tyr Lys Val Ser Asn Gly Lys Asp Asn Ile Ser Lys Val Ala 
     210                215                220
Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu Ser 
 225                230                235                240
Tyr Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro Leu 
                 245                250                255
Gly Glu Lys Ser Arg Thr Leu Arg Phe Phe Ser Ser Asp Ile Cys Arg 
             260                265                270
Ser Ile Tyr Ala Val Phe Glu Ser Glu Val Asn Leu Lys Gly Ile Pro 
         275                280                285
Val Tyr Arg Phe Val Leu Pro Ala Asn Ala Phe Ala Ser Pro Leu Gln 
     290                295                300
Asn Pro Asp Asn His Cys Phe Cys Thr Glu Lys Val Ile Ser Asn Asn 
 305                310                315                320
Cys Thr Ser Tyr Gly Val Leu Asp Ile Gly Lys Cys Lys Glu Gly Lys 
                 325                330                335
Pro Val Tyr Asn Ser Leu Pro His Phe Leu His Ala Ser Pro Asp Val 
             340                345                350
Ser Glu Pro Ile Glu Gly Leu Asn Pro Thr Glu Asp Glu His Arg Thr 
         355                360                365
Tyr Leu Asp Val Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ser Lys 
     370                375                380
Arg Leu Gln Val Asn Ile Leu Val Lys Pro Ala Arg Lys Ile Glu Ala 
 385                390                395                400
Leu Lys Asn Leu Lys Arg Pro Tyr Ile Val Pro Ile Leu Trp Leu Asn 
                 405                410                415
Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Glu Met Phe Arg Asn Gln 
             420                425                430
Val Thr Gly Lys Ile Lys Leu Leu Gly Leu Val Glu Met Val Leu Leu 
         435                440                445
Gly Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys Ala 
     450                455                460
Cys Arg Ser Lys Asn Gly Lys 
 465                470



<210> 6325
<211> 1749
<212> DNA
<213> Homo sapiens
<308> BC008406
<400> 6325

gaggactgc  gtgtaggac  ttcctgcag  ataccattt  atcctatta  gaattgtcc  60
aatgttgga  catttgatt  aaaaatcct  cttagccat  ttaaagata  ctttccaat  120
attagacga  ttgattctt  ctgtgactc  tcagttcat  tcctgtaaa  ttcatgtct  180
gctgttgat  tgtgaataa  aaccagagc  tgtagaaac  actttaatc  tatccagga  240
tttgcaaga  acaggtgct  aacactaat  cacctcctg  acaagaaaa  tgggctgtg  300
ccggaactg  gggctcatc  ctggggctg  cattggtgc  gtcctggct  tgtttggag  360
tattctaat  ccagttgga  acctgctta  ccagaagac  attaaaaag  aagttgtcc  420
cgaagaagg  acaattgct  ttaaaaatt  ggttaaaac  ggcacagaa  tttacagac  480
gttttggat  tttgatgtg  aaaatccac  ggaagtgat  atgaacagc  gcaacattc  540
agttaagca  agaggtcct  atacgtaca  agttcgttt  ctagccaag  aaaatgtaa  600
ccaggacgc  gaggacaac  cagtctctt  cctgcagcc  aatggtgcc  tcttcgaac  660
ttcactatc  gttggaaca  aggctgaca  cttcacagt  ctcaatctg  ctgtggcag  720
tgcatccca  atctatcaa  atcaatttg  tcaaatgat  ctcaattca  ttattaaca  780
gtcaaaatc  tctatgttc  aagtcagaa  tttgagaga  ctgttatgg  gctataggg  840
tccattttt  agtttggtt  cataccctg  tactaccac  gttggtctg  tttatcctt  900
caacaatac  gcagatgga  tttataaag  tttcaatgg  aaagataac  taagtaaag  960
tgccataat  gacacatat  aaggtaaaa  gaatctgtc  tattgggaa  gtcactgcg  1020
catgattaa  ggtacagat  cagcctcat  tccaccttt  gttgagaaa  gccaggtat  1080
gcagttctt  tcttctgat  tttgcaggt  aatctatgc  gtatttgaa  ccgacgtta  1140
tctgaaagg  atccctgtg  atagatttg  tcttccatc  aaggccttt  cctctccag  1200
tgaaaaccc  gacaactat  gtttctgca  agaaaaaat  atctcaaaa  attgtacat  1260
atatggtgt  ctagacatc  gcaaatgca  agaagggag  cctgtgtac  tttcacttc  1320
tcattttct  tatgcaagt  ctgatgttt  agaacctat  gatggatta  acccaaatg  1380
agaagaaca  aggacatac  tggatattg  acctataac  ggattcact  tacaatttg  1440
aaaacggct  caggtcaac  tattggtca  gccatcaga  aaaattcaa  tattaaaga  1500
tctgaagag  aactatatt  tgcctattc  ttggcttaa  gagactggg  ccattggtg  1560
tgagaaggc  aacatgttc  gaagtcaag  aactggaaa  ataaacctc  ttggcctga  1620
agaaatgat  ttactcagt  ttggtgtgg  gatgtttgt  gcttttatg  tttcatatt  1680
tgcatgcag  tcgaaaaca  taaaataag  aagtatgta  caaaaaaaa  aaaaaaaaa  1740
aaaaaaaaa  1749



<210> 6326
<211> 471
<212> PRT
<213> Homo sapiens
<308> P16671
<400> 6326

Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly Ala 
  1               5                  10                  15
Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu Leu 
             20                  25                  30
Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr Ile 
         35                  40                  45
Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln Phe 
     50                  55                  60
Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser Ser 
 65                  70                  75                  80
Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg Phe 
                 85                  90                  95
Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val Ser 
             100                105                110
Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val Gly 
         115                120                125
Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala Ala 
     130                135                140
Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser Leu 
 145                150                155                160
Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg Glu 
                 165                170                175
Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr Pro 
             180                185                190
Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala Asp 
         195                200                205
Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val Ala 
     210                215                220
Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu Ser 
 225                230                235                240
His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro Phe 
                 245                250                255
Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys Arg 
             260                265                270
Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile Pro 
         275                280                285
Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val Glu 
     290                295                300
Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys Asn 
 305                310                315                320
Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly Arg 
                 325                330                335
Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp Val 
             340                345                350
Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg Thr 
         355                360                365
Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala Lys 
     370                375                380
Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln Val 
 385                390                395                400
Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu Asn 
                 405                410                415
Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser Gln 
             420                425                430
Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu Leu 
         435                440                445
Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys Ala 
     450                455                460
Cys Arg Ser Lys Thr Ile Lys 
 465                470



<210> 6327
<211> 401
<212> DNA
<213> Rattus norvegicus
<308> AA925762
<400> 6327

ttttttttt  tttttttaa  tctgggtat  ggtgttttt  attcttttc  ttttccttc  60
tattcaaaa  gtgtagtgt  gtaaacctg  ctcacaaaa  acaccgtaa  aactttctt  120
aaaaaaaaa  aaaaaggaa  gaaggaaac  cctaagcct  tacaccgtc  tttttagtg  180
catattatc  tggcaatgt  atgcactgt  tcaatttcc  atagtggcc  ctatcactt  240
atttgatat  cctttttga  ccaaccatc  ccttcatat  tgggtacgt  catagattt  300
acaaagaaa  tttacattt  tttaataaa  atgcaaagt  tgcaaaaaa  attaatact  360
atgcaaaaa  aaaaagagt  aaagtaaag  aaaaaaaaa  c  401



<210> 6328
<211> 308
<212> PRT
<213> Rattus norvegicus
<308> P30009
<400> 6328

Gly Ala Gln Phe Ser Lys Thr Ala Ala Lys Gly Glu Ala Ala Ala Glu 
  1               5                  10                  15
Arg Pro Gly Glu Ala Ala Val Ala Ser Ser Pro Ser Lys Ala Asn Gly 
             20                  25                  30
Gln Glu Asn Gly His Val Lys Val Asn Gly Asp Ala Ser Pro Ala Ala 
         35                  40                  45
Ala Glu Pro Gly Ala Lys Glu Glu Leu Gln Ala Asn Gly Ser Ala Pro 
     50                  55                  60
Ala Ala Asp Lys Glu Glu Pro Ala Ser Gly Gly Ala Ala Thr Pro Ala 
 65                  70                  75                  80
Ala Ala Asp Lys Asp Glu Ala Ala Ala Ala Pro Glu Pro Gly Ala Ala 
                 85                  90                  95
Thr Ala Asp Lys Glu Ala Ala Glu Ala Glu Pro Ala Glu Pro Gly Ser 
             100                105                110
Pro Ser Ala Glu Thr Glu Gly Ala Ser Ala Ser Ser Thr Ser Ser Pro 
         115                120                125
Lys Ala Glu Asp Gly Ala Ala Pro Ser Pro Ser Ser Glu Thr Pro Lys 
     130                135                140
Lys Lys Lys Lys Arg Phe Ser Phe Lys Lys Ser Phe Lys Leu Ser Gly 
 145                150                155                160
Phe Ser Phe Lys Lys Ser Lys Lys Glu Ala Gly Glu Gly Ala Glu Ala 
                 165                170                175
Glu Gly Ala Thr Ala Asp Gly Ala Lys Asp Glu Ala Ala Ala Ala Ala 
             180                185                190
Gly Gly Asp Ala Ala Ala Ala Pro Gly Glu Gln Ala Gly Gly Ala Gly 
         195                200                205
Ala Glu Gly Ala Glu Gly Gly Glu Ser Arg Glu Ala Glu Ala Ala Glu 
     210                215                220
Pro Glu Gln Pro Glu Gln Pro Glu Gln Pro Ala Ala Glu Glu Pro Arg 
 225                230                235                240
Ala Glu Glu Pro Ser Glu Ala Val Gly Glu Lys Ala Glu Glu Pro Ala 
                 245                250                255
Pro Gly Ala Thr Ala Asp Asp Ala Pro Ser Ala Ala Gly Pro Glu Gln 
             260                265                270
Glu Ala Pro Ala Ala Thr Asp Glu Pro Ala Ala Ser Ala Ala Pro Ser 
         275                280                285
Ala Ser Pro Glu Pro Gln Pro Glu Cys Ser Pro Glu Ala Pro Pro Ala 
     290                295                300
Pro Val Ala Glu 
 305



<210> 6329
<211> 865
<212> DNA
<213> Homo sapiens
<308> AU141403
<400> 6329

cccattttt  taaaactgc  gtcatcttg  accttttaa  acacaaatt  taaactcaa  60
caagctgtg  taagtggaa  ggttactgt  tatactgtg  tatgttttt  attacagca  120
ataatgctt  cttttccag  cgtctttga  aataaagga  aaaaaatct  cagatgcaa  180
ggttttgtg  agcatcttg  ctatcatgt  ttgtaaata  tggagaagc  ttgaccaat  240
tgacttaga  atggaatgt  actttgctt  caaaaattg  tattaaact  ctgcttaag  300
tgttctaat  ttctgtgag  acactaaaa  cgaaaaata  atgtgaata  aatgtacaa  360
tttgttgtg  ttttttatg  tctaataat  ctgagactt  taggtctta  gttaatttt  420
aggaagatc  tgcatgcca  caggagtaa  ttttattgt  gttcttaat  tgaagtttt  480
aagctctga  attcataat  cgcagtgtc  gattacgta  aggaagatc  tacaacatt  540
catgtcaaa  ctgttacca  ttattggca  ttagttttc  tttaagaat  gaacataat  600
atttttatt  tagctatat  gcatgtcag  ttaaatcat  tacaacaaa  ggggtgtga  660
cctaagact  tttaaatgt  ttatgagaa  atttcataa  gccattctc  tgncattca  720
gtccagaaa  aaattttaa  ctgagtgag  gtctataga  tcctactgc  gatgggcat  780
aaatgtgac  aaatgtgtt  aaaaattga  ggggattac  tgctattgn  attgcttaa  840
gcttggcta  ttnccaaat  tggct  865



<210> 6330
<211> 406
<212> PRT
<213> Homo sapiens
<308> P50458
<400> 6330

Met Leu Phe His Ser Leu Ser Gly Pro Glu Val His Gly Val Ile Asp 
  1               5                  10                  15
Glu Met Asp Arg Arg Ala Lys Ser Glu Ala Pro Ala Ile Ser Ser Ala 
             20                  25                  30
Ile Asp Arg Gly Asp Thr Glu Thr Thr Met Pro Ser Ile Ser Ser Asp 
         35                  40                  45
Arg Ala Ala Leu Cys Ala Gly Cys Gly Gly Lys Ile Ser Asp Arg Tyr 
     50                  55                  60
Tyr Leu Leu Ala Val Asp Lys Gln Trp His Met Arg Cys Leu Lys Cys 
 65                  70                  75                  80
Cys Glu Cys Lys Leu Asn Leu Glu Ser Glu Leu Thr Cys Phe Ser Lys 
                 85                  90                  95
Asp Gly Ser Ile Tyr Cys Lys Glu Asp Tyr Tyr Arg Arg Phe Ser Val 
             100                105                110
Gln Arg Cys Ala Arg Cys His Leu Gly Ile Ser Ala Ser Glu Met Val 
         115                120                125
Met Arg Ala Arg Asp Leu Val Tyr His Leu Asn Cys Phe Thr Cys Thr 
     130                135                140
Thr Cys Asn Lys Met Leu Thr Thr Gly Asp His Phe Gly Met Lys Asp 
 145                150                155                160
Ser Leu Val Tyr Cys Arg Leu His Phe Glu Ala Leu Leu Gln Gly Glu 
                 165                170                175
Tyr Pro Ala His Phe Asn His Ala Asp Val Ala Ala Ala Ala Ala Ala 
             180                185                190
Ala Ala Ala Ala Lys Ser Ala Gly Leu Gly Ala Ala Gly Ala Asn Pro 
         195                200                205
Leu Gly Leu Pro Tyr Tyr Asn Gly Val Gly Thr Val Gln Lys Gly Arg 
     210                215                220
Pro Arg Lys Arg Lys Ser Pro Gly Pro Gly Ala Asp Leu Ala Ala Tyr 
 225                230                235                240
Asn Ala Ala Leu Ser Cys Asn Glu Asn Asp Ala Glu His Leu Asp Arg 
                 245                250                255
Asp Gln Pro Tyr Pro Ser Ser Gln Lys Thr Lys Arg Met Arg Thr Ser 
             260                265                270
Phe Lys His His Gln Leu Arg Thr Met Lys Ser Tyr Phe Ala Ile Asn 
         275                280                285
His Asn Pro Asp Ala Lys Asp Leu Lys Gln Leu Ala Gln Lys Thr Gly 
     290                295                300
Leu Thr Lys Arg Val Leu Gln Val Trp Phe Gln Asn Ala Arg Ala Lys 
 305                310                315                320
Phe Arg Arg Asn Leu Leu Arg Gln Glu Asn Thr Gly Val Asp Lys Ser 
                 325                330                335
Thr Asp Ala Ala Leu Gln Thr Gly Thr Pro Ser Gly Pro Ala Ser Glu 
             340                345                350
Leu Ser Asn Ala Ser Leu Ser Pro Ser Ser Thr Pro Thr Thr Leu Thr 
         355                360                365
Asp Leu Thr Ser Pro Thr Leu Pro Thr Val Thr Ser Val Leu Thr Ser 
     370                375                380
Val Pro Gly Asn Leu Glu Gly His Glu Pro His Ser Pro Ser Gln Thr 
 385                390                395                400
Thr Leu Thr Asn Leu Phe 
                 405



<210> 6331
<211> 401
<212> DNA
<213> Rattus norvegicus
<308> AA925762
<400> 6331

ttttttttt  tttttttaa  tctgggtat  ggtgttttt  attcttttc  ttttccttc  60
tattcaaaa  gtgtagtgt  gtaaacctg  ctcacaaaa  acaccgtaa  aactttctt  120
aaaaaaaaa  aaaaaggaa  gaaggaaac  cctaagcct  tacaccgtc  tttttagtg  180
catattatc  tggcaatgt  atgcactgt  tcaatttcc  atagtggcc  ctatcactt  240
atttgatat  cctttttga  ccaaccatc  ccttcatat  tgggtacgt  catagattt  300
acaaagaaa  tttacattt  tttaataaa  atgcaaagt  tgcaaaaaa  attaatact  360
atgcaaaaa  aaaaagagt  aaagtaaag  aaaaaaaaa  c  401



<210> 6332
<211> 308
<212> PRT
<213> Rattus norvegicus
<308> P30009
<400> 6332

Gly Ala Gln Phe Ser Lys Thr Ala Ala Lys Gly Glu Ala Ala Ala Glu 
  1               5                  10                  15
Arg Pro Gly Glu Ala Ala Val Ala Ser Ser Pro Ser Lys Ala Asn Gly 
             20                  25                  30
Gln Glu Asn Gly His Val Lys Val Asn Gly Asp Ala Ser Pro Ala Ala 
         35                  40                  45
Ala Glu Pro Gly Ala Lys Glu Glu Leu Gln Ala Asn Gly Ser Ala Pro 
     50                  55                  60
Ala Ala Asp Lys Glu Glu Pro Ala Ser Gly Gly Ala Ala Thr Pro Ala 
 65                  70                  75                  80
Ala Ala Asp Lys Asp Glu Ala Ala Ala Ala Pro Glu Pro Gly Ala Ala 
                 85                  90                  95
Thr Ala Asp Lys Glu Ala Ala Glu Ala Glu Pro Ala Glu Pro Gly Ser 
             100                105                110
Pro Ser Ala Glu Thr Glu Gly Ala Ser Ala Ser Ser Thr Ser Ser Pro 
         115                120                125
Lys Ala Glu Asp Gly Ala Ala Pro Ser Pro Ser Ser Glu Thr Pro Lys 
     130                135                140
Lys Lys Lys Lys Arg Phe Ser Phe Lys Lys Ser Phe Lys Leu Ser Gly 
 145                150                155                160
Phe Ser Phe Lys Lys Ser Lys Lys Glu Ala Gly Glu Gly Ala Glu Ala 
                 165                170                175
Glu Gly Ala Thr Ala Asp Gly Ala Lys Asp Glu Ala Ala Ala Ala Ala 
             180                185                190
Gly Gly Asp Ala Ala Ala Ala Pro Gly Glu Gln Ala Gly Gly Ala Gly 
         195                200                205
Ala Glu Gly Ala Glu Gly Gly Glu Ser Arg Glu Ala Glu Ala Ala Glu 
     210                215                220
Pro Glu Gln Pro Glu Gln Pro Glu Gln Pro Ala Ala Glu Glu Pro Arg 
 225                230                235                240
Ala Glu Glu Pro Ser Glu Ala Val Gly Glu Lys Ala Glu Glu Pro Ala 
                 245                250                255
Pro Gly Ala Thr Ala Asp Asp Ala Pro Ser Ala Ala Gly Pro Glu Gln 
             260                265                270
Glu Ala Pro Ala Ala Thr Asp Glu Pro Ala Ala Ser Ala Ala Pro Ser 
         275                280                285
Ala Ser Pro Glu Pro Gln Pro Glu Cys Ser Pro Glu Ala Pro Pro Ala 
     290                295                300
Pro Val Ala Glu 
 305



<210> 6333
<211> 865
<212> DNA
<213> Homo sapiens
<308> AU141403
<400> 6333

cccattttt  taaaactgc  gtcatcttg  accttttaa  acacaaatt  taaactcaa  60
caagctgtg  taagtggaa  ggttactgt  tatactgtg  tatgttttt  attacagca  120
ataatgctt  cttttccag  cgtctttga  aataaagga  aaaaaatct  cagatgcaa  180
ggttttgtg  agcatcttg  ctatcatgt  ttgtaaata  tggagaagc  ttgaccaat  240
tgacttaga  atggaatgt  actttgctt  caaaaattg  tattaaact  ctgcttaag  300
tgttctaat  ttctgtgag  acactaaaa  cgaaaaata  atgtgaata  aatgtacaa  360
tttgttgtg  ttttttatg  tctaataat  ctgagactt  taggtctta  gttaatttt  420
aggaagatc  tgcatgcca  caggagtaa  ttttattgt  gttcttaat  tgaagtttt  480
aagctctga  attcataat  cgcagtgtc  gattacgta  aggaagatc  tacaacatt  540
catgtcaaa  ctgttacca  ttattggca  ttagttttc  tttaagaat  gaacataat  600
atttttatt  tagctatat  gcatgtcag  ttaaatcat  tacaacaaa  ggggtgtga  660
cctaagact  tttaaatgt  ttatgagaa  atttcataa  gccattctc  tgncattca  720
gtccagaaa  aaattttaa  ctgagtgag  gtctataga  tcctactgc  gatgggcat  780
aaatgtgac  aaatgtgtt  aaaaattga  ggggattac  tgctattgn  attgcttaa  840
gcttggcta  ttnccaaat  tggct  865



<210> 6334
<211> 406
<212> PRT
<213> Homo sapiens
<308> P50458
<400> 6334

Met Leu Phe His Ser Leu Ser Gly Pro Glu Val His Gly Val Ile Asp 
  1               5                  10                  15
Glu Met Asp Arg Arg Ala Lys Ser Glu Ala Pro Ala Ile Ser Ser Ala 
             20                  25                  30
Ile Asp Arg Gly Asp Thr Glu Thr Thr Met Pro Ser Ile Ser Ser Asp 
         35                  40                  45
Arg Ala Ala Leu Cys Ala Gly Cys Gly Gly Lys Ile Ser Asp Arg Tyr 
     50                  55                  60
Tyr Leu Leu Ala Val Asp Lys Gln Trp His Met Arg Cys Leu Lys Cys 
 65                  70                  75                  80
Cys Glu Cys Lys Leu Asn Leu Glu Ser Glu Leu Thr Cys Phe Ser Lys 
                 85                  90                  95
Asp Gly Ser Ile Tyr Cys Lys Glu Asp Tyr Tyr Arg Arg Phe Ser Val 
             100                105                110
Gln Arg Cys Ala Arg Cys His Leu Gly Ile Ser Ala Ser Glu Met Val 
         115                120                125
Met Arg Ala Arg Asp Leu Val Tyr His Leu Asn Cys Phe Thr Cys Thr 
     130                135                140
Thr Cys Asn Lys Met Leu Thr Thr Gly Asp His Phe Gly Met Lys Asp 
 145                150                155                160
Ser Leu Val Tyr Cys Arg Leu His Phe Glu Ala Leu Leu Gln Gly Glu 
                 165                170                175
Tyr Pro Ala His Phe Asn His Ala Asp Val Ala Ala Ala Ala Ala Ala 
             180                185                190
Ala Ala Ala Ala Lys Ser Ala Gly Leu Gly Ala Ala Gly Ala Asn Pro 
         195                200                205
Leu Gly Leu Pro Tyr Tyr Asn Gly Val Gly Thr Val Gln Lys Gly Arg 
     210                215                220
Pro Arg Lys Arg Lys Ser Pro Gly Pro Gly Ala Asp Leu Ala Ala Tyr 
 225                230                235                240
Asn Ala Ala Leu Ser Cys Asn Glu Asn Asp Ala Glu His Leu Asp Arg 
                 245                250                255
Asp Gln Pro Tyr Pro Ser Ser Gln Lys Thr Lys Arg Met Arg Thr Ser 
             260                265                270
Phe Lys His His Gln Leu Arg Thr Met Lys Ser Tyr Phe Ala Ile Asn 
         275                280                285
His Asn Pro Asp Ala Lys Asp Leu Lys Gln Leu Ala Gln Lys Thr Gly 
     290                295                300
Leu Thr Lys Arg Val Leu Gln Val Trp Phe Gln Asn Ala Arg Ala Lys 
 305                310                315                320
Phe Arg Arg Asn Leu Leu Arg Gln Glu Asn Thr Gly Val Asp Lys Ser 
                 325                330                335
Thr Asp Ala Ala Leu Gln Thr Gly Thr Pro Ser Gly Pro Ala Ser Glu 
             340                345                350
Leu Ser Asn Ala Ser Leu Ser Pro Ser Ser Thr Pro Thr Thr Leu Thr 
         355                360                365
Asp Leu Thr Ser Pro Thr Leu Pro Thr Val Thr Ser Val Leu Thr Ser 
     370                375                380
Val Pro Gly Asn Leu Glu Gly His Glu Pro His Ser Pro Ser Gln Thr 
 385                390                395                400
Thr Leu Thr Asn Leu Phe 
                 405



<210> 6335
<211> 341
<212> DNA
<213> Rattus norvegicus
<308> AA926137
<400> 6335

ttttttttt  tttttttcc  gaaaatact  gagtgtaat  aggatttct  cctgacatt  60
gactctccc  acatgcaag  gttgggagc  caaaggatt  ttgagctgg  aaatcctca  120
gggagatga  gtagaggga  ccaggcgtc  aaggcgtac  aacaaggtt  aatgctgca  180
ccgtcaagg  aggagctcc  cagatcgat  cagacttct  cctccgtgt  ctccacagg  240
ctaagctgt  tctgaggcc  cagcgcatg  taccatcga  gcctgtggt  gggganggg  300
ctgcctaat  gtccttctt  aacttgcca  tgatgtacg  c  341



<210> 6336
<211> 466
<212> DNA
<213> Rattus norvegicus
<308> AA926149
<400> 6336

ttttttttt  tttttttcc  tgaagatca  tttattgta  aaatgtaag  aaatacaaa  60
caccctatg  gaaatcact  tgtatcagc  taaacataa  ttcaagggg  aaaggaatc  120
gatcaacta  acaggaata  acattaagt  tcaacagtg  taaagttat  tttggaaga  180
atgatccaa  tatggtttt  cttataagg  ccttagaaa  ataaaaaaa  aattctggg  240
gggccatct  tataatccc  tcattcatg  gtgtgtgtg  gaaatttta  attttttaa  300
aatattaat  aaaacaaac  atgagaatg  aatatggaa  ggataagag  aatcactaa  360
ctttttcaa  ttctttctc  agtgaacat  ggctcgcca  taattacta  gtgtggtag  420
aaacaaagt  gtttacatt  caaattctc  aagggtcat  tcgggt  466



<210> 6337
<211> 526
<212> PRT
<213> Rattus norvegicus
<308> P04762
<400> 6337

Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Lys Gln Trp Lys Glu 
  1               5                  10                  15
Gln Arg Ala Pro Gln Lys Pro Asp Val Leu Thr Thr Gly Gly Gly Asn 
             20                  25                  30
Pro Ile Gly Asp Lys Leu Asn Ile Met Thr Ala Gly Pro Arg Gly Pro 
         35                  40                  45
Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe Asp 
     50                  55                  60
Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly Ala 
 65                  70                  75                  80
Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Arg Tyr Ser Lys Ala 
                 85                  90                  95
Lys Val Phe Glu His Ile Gly Lys Arg Thr Pro Ile Ala Val Arg Phe 
             100                105                110
Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp Pro 
         115                120                125
Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp Leu 
     130                135                140
Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Ala Met Leu Phe 
 145                150                155                160
Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu Lys 
                 165                170                175
Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Cys Pro Glu Ser Leu 
             180                185                190
His Gln Val Thr Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly His 
         195                200                205
Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn Ala 
     210                215                220
Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln Gly 
 225                230                235                240
Ile Lys Asn Leu Pro Val Glu Glu Ala Gly Arg Leu Ala Gln Glu Asp 
                 245                250                255
Pro Asp Tyr Gly Leu Arg Asp Leu Phe Asn Ala Ile Ala Ser Gly Asn 
             260                265                270
Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Lys Glu Ala 
         275                280                285
Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro His 
     290                295                300
Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg Asn 
 305                310                315                320
Pro Ala Asn Tyr Phe Ala Glu Val Glu Gln Met Ala Phe Asp Pro Ser 
                 325                330                335
Asn Met Pro Pro Gly Ile Glu Pro Ser Pro Asp Lys Met Leu Gln Gly 
             340                345                350
Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro Asn 
         355                360                365
Tyr Leu Gln Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala Asn 
     370                375                380
Tyr Gln Arg Asp Gly Pro Met Cys Met His Asp Asn Gln Gly Gly Ala 
 385                390                395                400
Pro Asn Tyr Tyr Pro Asn Ser Phe Ser Ala Pro Glu Gln Gln Gly Ser 
                 405                410                415
Ala Leu Glu His His Ser Gln Cys Ser Ala Asp Val Lys Arg Phe Asn 
             420                425                430
Ser Ala Asn Glu Asp Asn Val Thr Gln Val Arg Thr Phe Tyr Thr Lys 
         435                440                445
Val Leu Asn Glu Glu Glu Arg Lys Arg Leu Cys Glu Asn Ile Ala Asn 
     450                455                460
His Leu Lys Asp Ala Gln Leu Phe Ile Gln Arg Lys Ala Val Lys Asn 
 465                470                475                480
Phe Thr Asp Val His Pro Asp Tyr Gly Ala Arg Val Gln Ala Leu Leu 
                 485                490                495
Asp Gln Tyr Asn Ser Gln Lys Pro Lys Asn Ala Ile His Thr Tyr Val 
             500                505                510
Gln Ala Gly Ser His Ile Ala Ala Lys Gly Lys Ala Asn Leu 
         515                520                525



<210> 6338
<211> 2264
<212> DNA
<213> Homo sapiens
<308> X04076
<400> 6338

tttgcctgc  gagggtgga  acccacgag  cgaggcctc  tgcagtgtt  tgcacagca  60
accgcacgc  atggctgac  gccgggatc  cgccagcga  cagatgcag  actggaagg  120
gcagcgggc  gcgcagaaa  ctgatgtcc  gaccactgg  gctggtaac  cagtaggag  180
caaacttaa  gttattaca  tagggcccc  tgggcccct  cttgttcag  atgtggttt  240
cactgatga  atggctcat  ttgaccgag  gagaattcc  gagagagtt  tgcatgcta  300
aggagcagg  gcctttggc  actttgagg  cacacatga  attaccaaa  actccaagg  360
aaaggtatt  gagcatatt  gaaagaaga  tcccatcgc  gttcggttc  ccactgttg  420
tggagaatc  ggttcagct  acacagttc  ggaccctcg  gggtttgca  tgaaatttt  480
cacagaaga  ggtaactgg  atctcgttg  aaataacac  cccattttc  tcatcaggg  540
tcccatatt  tttccatct  ttatccaca  ccaaaagag  aatcctcag  cacatctga  600
ggatccgga  atggtctgg  acttctgga  cctacgtcc  gagtctctg  atcaggttt  660
tttcttgtt  agtgatcgg  ggattccag  tggacatcg  cacatgaat  gatatggat  720
acatacttt  aagctggtt  atgcaaatg  ggaggcagt  tattgcaaa  tccattata  780
gactgacca  ggcatcaaa  acctttctg  tgaagatgc  gcgagactt  cccaggaag  840
tcctgacta  ggcatccgg  atcttttta  cgccattgc  acaggaaag  acccctcct  900
gacttttta  atccaggtc  tgacattta  tcaggcaga  acttttcca  ttaatccat  960
cgatctcac  aaggtttgg  ctcacaagg  ctaccctct  atcccagtt  gtaaactgg  1020
cttaaaccg  aatccagtt  attactttg  tgaggttga  cagatagcc  tcgacccaa  1080
caacatgcc  cctggcatt  aggccagtc  tgacaaaat  cttcagggc  gcctttttg  1140
ctatcctga  actcaccgc  atcgcctgg  acccaatta  cttcatata  ctgtgaact  1200
tccctaccg  gctcgagtg  ccaactacc  gcgtgatgg  ccgatgtgc  tgcaggaca  1260
tcagggtgg  gctccaaat  actacccca  cagctttgg  gctccggaa  aacagcctt  1320
tgccctgga  cacagcatc  aatattctg  agaagtgcg  agattcaac  ctgccaatg  1380
tgataacgt  actcaggtg  gggcattct  tgtgaacgt  ctgaatgag  aacagagga  1440
acgtctgtg  gagaacatt  ccggccacc  gaaggatgc  caaattttc  tccagaaga  1500
agcggtcaa  aacttcact  aggtccacc  tgactacgg  agccacatc  aggctcttc  1560
ggacaagta  aatgctgag  agcctaaga  tgcgattca  acctttgtg  agtccggat  1620
tcacttggc  gcaagggag  aggcaaatc  gtgaggccg  ggccctgca  ctgtgcagc  1680
aacgttagc  ttcatccgt  taacccgct  atcactgga  gaagattct  ctgtgctag  1740
tgtgcaaat  caagctagt  gcttcaaaa  agagaatcc  actttctat  gcagattgt  1800
taacaattt  aatgctatt  ccccagggg  aaatgaagg  taggattta  cagtcattt  1860
aaaaaaaaa  ttgttttga  ggatgattg  attattcat  taaaatgat  agaaggcaa  1920
tttctagct  agaaatatg  ttttatttg  caaaatttg  tgaaattat  tatgtttac  1980
tatcacctc  tggcctatt  tattaaaat  tggctataa  tatataaaa  gaaaagata  2040
agatgatct  ctcagaaat  tttattttt  taaggttct  ataggaaaa  tacatttaa  2100
acagcagtg  catcagaag  taacttgag  accgtcatg  cttaatgtt  attcctgat  2160
ataattgat  aaattcatt  ttttcactg  agttacatt  atgttaatt  agcactgat  2220
tcacaacag  tcaatttgt  attgcttac  tttttacaa  aaat  2264



<210> 6339
<211> 526
<212> PRT
<213> Homo sapiens
<308> P04040
<400> 6339

Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys Glu 
  1               5                  10                  15
Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly Asn 
             20                  25                  30
Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly Pro 
         35                  40                  45
Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe Asp 
     50                  55                  60
Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly Ala 
 65                  70                  75                  80
Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys Ala 
                 85                  90                  95
Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg Phe 
             100                105                110
Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp Pro 
         115                120                125
Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp Leu 
     130                135                140
Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu Phe 
 145                150                155                160
Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu Lys 
                 165                170                175
Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser Leu 
             180                185                190
His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly His 
         195                200                205
Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn Ala 
     210                215                220
Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln Gly 
 225                230                235                240
Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu Asp 
                 245                250                255
Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly Lys 
             260                265                270
Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln Ala 
         275                280                285
Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro His 
     290                295                300
Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg Asn 
 305                310                315                320
Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro Ser 
                 325                330                335
Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln Gly 
             340                345                350
Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro Asn 
         355                360                365
Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala Asn 
     370                375                380
Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly Ala 
 385                390                395                400
Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro Ser 
                 405                410                415
Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe Asn 
             420                425                430
Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val Asn 
         435                440                445
Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala Gly 
     450                455                460
His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys Asn 
 465                470                475                480
Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu Leu 
                 485                490                495
Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe Val 
             500                505                510
Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu 
         515                520                525



<210> 6340
<211> 407
<212> DNA
<213> Rattus norvegicus
<308> AA926242
<400> 6340

ttttttttt  tttaaatat  gtgatgatt  ttgaactga  ccagtgtgt  cttgcatac  60
gtcacccca  taggaactt  ctggaaaga  gcaggttta  gccttgtgg  agaaaacac  120
tagggcttt  gtatacagg  aagagtttc  cacagtcag  tttgctttc  tggtctgca  180
taggtaaga  agacattta  aaactccgt  cgttctcca  attcctcca  actgtttaa  240
atgccaggg  atgagtaat  tctttccta  cctgtcata  ctactcatg  aattgtaag  300
aaccaagta  gttccctga  ataaccaaa  atgtcttgg  ttatgctgt  tctaaagtt  360
tattccagt  tatatggtt  cacctaaag  gagaaaact  ttaacta  407



<210> 6341
<211> 357
<212> PRT
<213> Rattus norvegicus
<308> P19814
<400> 6341

Met Gln Phe Leu Val Ala Leu Leu Leu Leu Ser Val Ala Val Ala Arg 
  1               5                  10                  15
Ala Leu Pro Ser Ala Ser Lys Pro Asn Asn Thr Ser Ser Glu Asn Asn 
             20                  25                  30
Pro Pro Ile Gln Pro Ser Thr Pro Leu Pro Pro Gly Val Asp Ile Ser 
         35                  40                  45
Gln Gln Val Lys Thr Asn Arg Pro Thr Asp Gln Arg Leu Glu Ser Asp 
     50                  55                  60
Lys Glu Gly Gln Asp Lys Thr Val Ala Arg Thr Ser Ala Ser Val Ser 
 65                  70                  75                  80
Ser Gly Val Glu Ser Ala Thr Asn Leu Asn Leu Asp Asp Ser Lys Lys 
                 85                  90                  95
His Pro Glu Thr Ala Asp Ala Lys Leu Lys Glu Thr Leu Gln Gln Leu 
             100                105                110
Leu Pro Val Asp Pro Lys Gln Glu Lys Ser Gly Gln Lys Phe Thr Lys 
         115                120                125
Asp Ser Gly Ser Pro Thr Gly Gly Asp Ser Asp Asn Thr Thr Gly Gly 
     130                135                140
Asp Ser Asn Lys Thr Thr Gly Val Asp Ser Asp Lys Thr Ser Gly Gly 
 145                150                155                160
Asp Ser Asn Lys Pro Thr Gly Ser Asp Asn Asp Lys Pro Thr Gly Gly 
                 165                170                175
Asp Ser Asn Lys Pro Thr Ser Lys Val Pro Ser Asn Thr Glu Thr Pro 
             180                185                190
Lys Ile Asp Lys Val Gln Leu Thr Glu Lys Gly Gln Lys Pro Thr Leu 
         195                200                205
Ile Ser Lys Thr Glu Ser Gly Glu Lys Leu Ala Gly Asp Ser Asp Phe 
     210                215                220
Ser Leu Lys Pro Glu Lys Gly Asp Lys Ser Ser Glu Pro Thr Glu Asp 
 225                230                235                240
Val Glu Thr Lys Glu Ile Glu Glu Gly Asp Thr Glu Pro Glu Glu Gly 
                 245                250                255
Ser Pro Leu Glu Glu Glu Asn Glu Lys Val Leu Gly Pro Ser Ser Ser 
             260                265                270
Glu Asn Gln Glu Gly Thr Leu Thr Asp Ser Met Lys Asp Glu Lys Asp 
         275                280                285
Asp His Tyr Lys Asp Asn Ser Gly Asn Thr Ser Ala Glu Ser Ser His 
     290                295                300
Phe Phe Ala Tyr Leu Val Thr Ala Ala Val Leu Val Ala Val Leu Tyr 
 305                310                315                320
Ile Ala Tyr His Asn Lys Arg Lys Ile Ile Ala Phe Ala Leu Glu Gly 
                 325                330                335
Lys Arg Ser Lys Val Thr Arg Arg Pro Lys Ala Ser Asp Tyr Gln Arg 
             340                345                350
Leu Asn Leu Lys Leu 
         355



<210> 6342
<211> 1494
<212> DNA
<213> Homo sapiens
<308> BC008461
<400> 6342

agagggcgg  agcgctatc  gagcaggat  cggttcgta  ttgccttgg  cctcctgaa  60
gtcgcagcg  cgggagccg  gccgctctt  gccaccgaa  gcgtcaagc  agaagatgc  120
ggagtacgg  cttctgcag  aaacgtctc  acccacccc  gcttgagcc  acggcctgg  180
ggctctacc  agtcgcatc  ggagccgca  actccaaaa  acagcccta  caagtcgag  240
gcggaggcg  agaccccag  agacacccc  aacaagtcg  gtgcggagg  aaagaccca  300
aaagacagc  ccaacaagt  gggtgcgga  gcaaagacc  aaaaaggca  cactagcaa  360
tcgggttcg  aggcgcaga  cacaaaaga  agcactagt  agtcgcatc  ggagctgca  420
actccaaaa  acagcactg  caaatcggg  gcggaggcg  agaccccag  agacagccc  480
aacaggtcg  gtgcggagg  aaagaccca  aaagacagc  ctagcaagt  aggttcgga  540
gcgcagacc  caaaagatg  ccctaataa  tcgggtgcg  acggccaga  cccaaaaga  600
ggctccagc  agtcgggtg  ggaggatca  accccaaaa  acgtcccta  caagtcggg  660
gcggagaag  agactccaa  agacggctc  aacaagtcc  gtgcagagg  gcagggccc  720
atagacggg  ccagcaagt  gggtgcgga  gagcagacc  caaaagaca  ccctaacaa  780
gtggttcca  agcagcctt  ccggaaaga  cattccaag  ccatctcca  cccttctga  840
aacaaggag  tccccaagg  tgacacaaa  cagcttgct  acaaaggga  gctttctcc  900
catgctttc  aaaccgaat  tggggagga  actgacctc  tttctcccc  gcaggagga  960
gttaagtct  cagagccta  tgaggatgt  gagcccaaa  aggctgaag  tgatgatac  1020
ggacccgag  agggctcac  gcccaaaga  gagaaagaa  agatgtccg  ttctgcctc  1080
agtgagaac  gtgaaggga  actttcgga  tccacgggt  gcgagaagg  tgaccttta  1140
ccgaacggt  ctggaaatg  cagcgcgga  agcagccac  tctttgcat  tctggtgac  1200
gcagccatt  ttgtggctg  cctctatat  gctcatcac  acaagcgga  gatcattgc  1260
tttgtcctg  aaggaaaaa  atctaaagt  acccggcgg  caaaggcca  tgactacca  1320
cgtttggac  agaagtcct  acagaatgg  atattcctc  ggaaaaaga  gaacgtcac  1380
aatggattg  gctgctctc  tttcagctt  gattttttt  tccttgaga  ccttgtcct  1440
cctgctgat  tgtttctaa  gcaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaa  1494



<210> 6343
<211> 480
<212> PRT
<213> Homo sapiens
<308> O43493
<400> 6343

Met Arg Phe Val Val Ala Leu Val Leu Leu Asn Val Ala Ala Ala Gly 
  1               5                  10                  15
Ala Val Pro Leu Leu Ala Thr Glu Ser Val Lys Gln Glu Glu Ala Gly 
             20                  25                  30
Val Arg Pro Ser Ala Gly Asn Val Ser Thr His Pro Ser Leu Ser Gln 
         35                  40                  45
Arg Pro Gly Gly Ser Thr Lys Ser His Pro Glu Pro Gln Thr Pro Lys 
     50                  55                  60
Asp Ser Pro Ser Lys Ser Ser Ala Glu Ala Gln Thr Pro Glu Asp Thr 
 65                  70                  75                  80
Pro Asn Lys Ser Gly Gly Glu Ala Lys Thr Leu Lys Asp Ser Ser Asn 
                 85                  90                  95
Lys Ser Gly Ala Glu Ala Gln Thr Pro Lys Gly Ser Thr Ser Lys Ser 
             100                105                110
Gly Ser Glu Ala Gln Thr Thr Lys Asp Ser Thr Ser Lys Ser His Pro 
         115                120                125
Glu Leu Gln Thr Pro Lys Asp Ser Thr Gly Lys Ser Gly Ala Glu Ala 
     130                135                140
Gln Thr Pro Glu Asp Ser Pro Asn Arg Ser Gly Ala Glu Pro Lys Thr 
 145                150                155                160
Gln Lys Asp Ser Pro Ser Lys Ser Gly Ser Glu Ala Gln Thr Thr Lys 
                 165                170                175
Asp Val Pro Asn Lys Ser Gly Ala Asp Gly Gln Thr Pro Lys Asp Gly 
             180                185                190
Ser Ser Lys Ser Gly Ala Glu Asp Gln Thr Pro Lys Asp Val Pro Asn 
         195                200                205
Lys Ser Gly Ala Glu Lys Gln Thr Pro Lys Asp Gly Ser Asn Lys Ser 
     210                215                220
Gly Ala Glu Glu Gln Gly Pro Ile Asp Gly Pro Ser Lys Ser Gly Ala 
 225                230                235                240
Glu Glu Gln Thr Ser Lys Asp Ser Pro Asn Lys Val Val Pro Glu Gln 
                 245                250                255
Pro Ser Arg Lys Asp His Ser Lys Pro Ile Ser Asn Pro Ser Asp Asn 
             260                265                270
Lys Glu Leu Pro Lys Ala Asp Thr Asn Gln Leu Ala Asp Lys Gly Lys 
         275                280                285
Leu Ser Pro His Ala Phe Lys Thr Glu Ser Gly Glu Glu Thr Asp Leu 
     290                295                300
Ile Ser Pro Pro Gln Glu Glu Val Lys Ser Ser Glu Pro Thr Glu Asp 
 305                310                315                320
Val Gly Pro Lys Glu Ala Glu Asp Asp Asp Thr Gly Pro Glu Glu Gly 
                 325                330                335
Ser Pro Pro Lys Glu Glu Lys Glu Lys Met Ser Gly Ser Ala Ser Ser 
             340                345                350
Glu Asn Arg Glu Gly Thr Leu Ser Asp Ser Thr Gly Ser Glu Lys Asp 
         355                360                365
Asp Leu Tyr Pro Asn Gly Ser Gly Asn Gly Ser Ala Glu Ser Ser His 
     370                375                380
Phe Phe Ala Tyr Leu Val Thr Ala Ala Ile Leu Val Ala Val Leu Tyr 
 385                390                395                400
Ile Ala His His Asn Lys Arg Lys Ile Ile Ala Phe Val Leu Glu Gly 
                 405                410                415
Lys Arg Ser Lys Val Thr Arg Arg Pro Lys Ala Ser Asp Tyr Gln Arg 
             420                425                430
Leu Asp Gln Lys Tyr Val Leu Ile Leu Asn Val Phe Pro Ala Pro Pro 
         435                440                445
Lys Arg Ser Phe Leu Pro Gln Val Leu Thr Glu Trp Tyr Ile Pro Leu 
     450                455                460
Glu Lys Asp Glu Arg His Gln Trp Ile Val Leu Leu Ser Phe Gln Leu 
 465                470                475                480



<210> 6344
<211> 400
<212> DNA
<213> Rattus norvegicus
<308> AA933158
<400> 6344

ttttttttt  tttttttgc  ctgtagttt  tgtttttta  ttttatagt  ttaagtttt  60
caaaacata  tttcttcat  tagccctgg  tgtcccgga  ctaagctct  tagagcagg  120
tggcctccg  ctcaggtct  ccggctgtt  tgcttttat  cacacatcc  ttactgggt  180
tagaggctg  ctgcgaaga  gatgtccct  cggagcaag  tggctgccg  ctccatctt  240
gcccctaac  caggctctc  taccaaacg  gccgcccct  gaagtgagc  gcacatctc  300
gccaggcgc  ggatacagc  gacaaccaa  ccttcgggg  tccccgaga  ccctgccaa  360
tcggagaag  gcatacccc  agcccactc  taaacaactt  400



<210> 6345
<211> 1236
<212> PRT
<213> Rattus norvegicus
<308> NP_067312
<400> 6345

Met Met Glu Thr Glu Arg Leu Asp Pro Leu Asn Leu Pro Leu Arg Ala 
  1               5                  10                  15
Leu Glu Val Gly Cys Thr Gly Arg Trp Glu Leu Leu Asn Val Pro Gly 
             20                  25                  30
Pro Pro Glu Ser Thr Leu Pro His Gly Leu Pro Pro Cys Ala Pro Asp 
         35                  40                  45
Leu Cys Gln Glu Ala Glu Gln Leu Phe Leu Ser Ser Pro Ala Trp Leu 
     50                  55                  60
Pro Leu His Gly Val Glu His Ser Ala Arg Lys Trp Gln Arg Lys Thr 
 65                  70                  75                  80
Asp Pro Trp Ser Leu Leu Ala Ala Val Glu Thr Pro Val Pro Ser Asp 
                 85                  90                  95
Leu Gln Ala Gln Arg His Pro Thr Thr Gly His Ile Leu Gly Tyr Lys 
             100                105                110
Glu Val Leu Leu Glu Asn Thr Asn Leu Ser Ala Thr Thr Ser Leu Ser 
         115                120                125
Leu Arg Arg Pro Pro Gly Pro Ala Ser Gln Ser Leu Trp Gly Asn Pro 
     130                135                140
Thr Gln Tyr Pro Phe Trp Pro Gly Gly Met Asp Glu Pro Ser Ile Thr 
 145                150                155                160
Asp Leu His Thr Arg Glu Glu Ala Glu Glu Glu Ile Asp Phe Glu Lys 
                 165                170                175
Asp Leu Leu Thr Val Pro Pro Gly Phe Lys Lys Gly Val Asp Phe Ala 
             180                185                190
Pro Lys Ala Pro Val Pro Gly Leu Leu Ser Leu Ser Arg Leu Leu Glu 
         195                200                205
Pro Leu Asp Leu Ser Gly Gly Asp Glu Asp Glu Gly Glu Ala Ala Gly 
     210                215                220
Gly Pro Arg Gly Asp Asn Ala Ser Pro Ser Pro Ser Gly Thr Pro Leu 
 225                230                235                240
Val Arg Ala Ser Ser Leu Glu Asp Leu Val Leu Lys Glu Ala Ala Thr 
                 245                250                255
Val Val Ser Thr Pro Glu Pro Pro Lys Pro Pro Pro Gln Glu Gln Trp 
             260                265                270
Ala Val Pro Val Asp Val Thr Ser Pro Val Gly Asp Phe Tyr Arg Leu 
         275                280                285
Ile Pro Gln Pro Ala Phe Gln Trp Ala Phe Glu Pro Asp Val Phe Gln 
     290                295                300
Lys Gln Ala Ile Leu His Leu Glu Gln His Asp Ser Val Phe Val Ala 
 305                310                315                320
Ala His Thr Ser Ala Gly Lys Thr Val Val Ala Glu Tyr Ala Ile Ala 
                 325                330                335
Leu Ala Gln Lys His Met Thr Arg Thr Ile Tyr Thr Ser Pro Ile Lys 
             340                345                350
Ala Leu Ser Asn Gln Lys Phe Arg Asp Phe Arg Asn Thr Phe Gly Asp 
         355                360                365
Val Gly Leu Leu Thr Gly Asp Val Gln Leu His Pro Glu Ala Ser Cys 
     370                375                380
Leu Ile Met Thr Thr Glu Ile Leu Arg Ser Met Leu Tyr Ser Gly Ser 
 385                390                395                400
Asp Val Ile Arg Asp Leu Glu Trp Val Ile Phe Asp Glu Val His Tyr 
                 405                410                415
Ile Asn Asp Ala Glu Arg Gly Val Val Trp Glu Glu Val Leu Ile Met 
             420                425                430
Leu Pro Glu His Val Ser Ile Ile Leu Leu Ser Ala Thr Val Pro Asn 
         435                440                445
Ala Leu Glu Phe Ala Asp Trp Ile Gly Arg Leu Lys Arg Arg Gln Ile 
     450                455                460
Tyr Val Ile Ser Thr Val Ala Arg Pro Val Pro Leu Glu His Tyr Leu 
 465                470                475                480
Phe Thr Gly Asn Ser Pro Lys Thr Gln Gly Glu Leu Phe Leu Leu Leu 
                 485                490                495
Asp Ser Arg Gly Ala Phe His Thr Gln Gly Tyr Tyr Ala Ala Val Glu 
             500                505                510
Ala Lys Lys Glu Arg Met Ser Lys His Ala Gln Thr Phe Gly Ala Lys 
         515                520                525
Gln Pro Thr His Gln Gly Gly Pro Ala Gln Asp Arg Gly Val Tyr Leu 
     530                535                540
Ser Leu Leu Ala Ser Leu Arg Thr Arg Ala Gln Leu Pro Val Val Val 
 545                550                555                560
Phe Thr Phe Ser Arg Gly Arg Cys Asp Glu Gln Ala Ser Gly Leu Thr 
                 565                570                575
Ser Leu Asp Leu Thr Thr Ser Ser Glu Lys Ser Glu Ile His Leu Phe 
             580                585                590
Leu Gln Arg Cys Leu Ala Arg Leu Arg Gly Ser Asp Arg Gln Leu Pro 
         595                600                605
Gln Val Leu His Met Ser Glu Leu Leu Arg Arg Gly Leu Gly Val His 
     610                615                620
His Ser Gly Ile Leu Pro Ile Leu Lys Glu Ile Val Glu Met Leu Phe 
 625                630                635                640
Ser Arg Gly Leu Val Lys Val Leu Phe Ala Thr Glu Thr Phe Ala Met 
                 645                650                655
Gly Val Asn Met Pro Ala Arg Thr Val Val Phe Asp Ser Met Arg Lys 
             660                665                670
His Asp Gly Ser Thr Phe Arg Asp Leu Leu Pro Gly Glu Tyr Val Gln 
         675                680                685
Met Ala Gly Arg Ala Gly Arg Arg Gly Leu Asp Pro Thr Gly Thr Val 
     690                695                700
Ile Leu Leu Cys Lys Gly Arg Val Pro Glu Met Ala Asp Leu His Arg 
 705                710                715                720
Met Met Met Gly Lys Pro Ser Gln Leu Gln Ser Gln Phe Arg Leu Thr 
                 725                730                735
Tyr Thr Met Ile Leu Asn Leu Leu Arg Val Asp Ala Leu Arg Val Glu 
             740                745                750
Asp Met Met Lys Arg Ser Phe Ser Glu Phe Pro Ser Arg Lys Asp Ser 
         755                760                765
Lys Ala His Glu Gln Ala Leu Ala Asp Leu Thr Lys Arg Leu Gly Ala 
     770                775                780
Leu Glu Glu Pro Asp Val Thr Gly Gln Leu Ala Asp Leu Pro Glu Tyr 
 785                790                795                800
Tyr Ser Trp Ala Glu Glu Leu Thr Glu Thr Gln Asn Met Ile Gln Arg 
                 805                810                815
Arg Ile Met Glu Ser Val Asn Gly Leu Lys Ser Leu Ser Val Gly Arg 
             820                825                830
Val Val Val Val Lys Asn Glu Glu His His Asn Ala Leu Gly Val Ile 
         835                840                845
Leu Gln Val Ser Ser Asn Ser Thr Ser Arg Val Phe Thr Thr Leu Val 
     850                855                860
Leu Cys Asp Lys Pro Val Val Ser Asp Asn Pro Arg Asp Lys Gly Pro 
 865                870                875                880
Ala Thr Pro Asp Val Pro His Pro Asp Asp Leu Ile Gly Phe Lys Leu 
                 885                890                895
Phe Leu Pro Glu Gly Pro Cys Glu His Thr Val Ala Lys Leu Gln Pro 
             900                905                910
Gly Asp Val Ala Ala Ile Ser Thr Lys Val Leu Arg Val Asn Gly Glu 
         915                920                925
Lys Ile Ser Glu Asp Phe Ser Lys Arg Gln Gln Pro Lys Phe Arg Lys 
     930                935                940
Asp Pro Pro Leu Ala Ala Val Thr Thr Ala Val Gln Glu Leu Leu Arg 
 945                950                955                960
Leu Ala Gln Ser Tyr Pro Ala Gly Pro Pro Thr Leu Asp Pro Ile Asn 
                 965                970                975
Asp Leu Gln Leu Lys Asp Val Ala Val Val Glu Gly Gly Leu Arg Ala 
             980                985                990
Arg Lys Leu Glu Glu Leu Ile Arg Gly Ala Gln Cys Val His Ser Pro 
         995                1000                1005
Arg Phe Pro Ala Gln Tyr Val Lys Leu Arg Glu Arg Met Gln Ile Gln 
     1010                1015                1020
Lys Glu Met Glu Arg Leu Arg Phe Leu Leu Ser Asp Gln Ser Leu Leu 
 1025                1030                1035                1040
Leu Leu Pro Glu Tyr His Gln Arg Val Glu Val Leu Arg Thr Leu Gly 
                 1045                1050                1055
Tyr Val Asp Glu Ala Gly Thr Val Lys Leu Ala Gly Arg Val Ala Cys 
             1060                1065                1070
Ala Met Ser Ser His Glu Leu Leu Leu Thr Glu Leu Met Phe Asp Asn 
         1075                1080                1085
Ala Leu Ser Ala Leu Arg Pro Glu Glu Ile Ala Ala Leu Leu Ser Gly 
     1090                1095                1100
Leu Val Cys Gln Ser Pro Gly Asp Pro Gly Asp Gln Leu Pro Ser Thr 
 1105                1110                1115                1120
Leu Lys Gln Gly Val Glu Arg Val Lys Ala Val Ala Lys Arg Ile Gly 
                 1125                1130                1135
Glu Val Gln Val Ala Cys Gly Leu Asn Gln Thr Val Glu Glu Phe Val 
             1140                1145                1150
Gly Glu Leu Asn Phe Gly Leu Val Glu Val Val Tyr Glu Trp Ala Arg 
         1155                1160                1165
Gly Met Pro Phe Ser Glu Leu Ala Gly Leu Ser Gly Thr Pro Glu Gly 
     1170                1175                1180
Leu Val Val Arg Cys Ile Gln Arg Leu Ala Glu Met Cys Arg Ser Leu 
 1185                1190                1195                1200
Arg Gly Ala Ala Arg Leu Val Gly Glu Pro Val Leu Gly Ala Lys Met 
                 1205                1210                1215
Glu Thr Ala Ala Thr Leu Leu Arg Arg Asp Ile Val Phe Ala Ala Ser 
             1220                1225                1230
Leu Tyr Thr Gln 
         1235



<210> 6346
<211> 435
<212> DNA
<213> Rattus norvegicus
<308> AA943555
<400> 6346

aagcttgcc  ctctggcag  gcttctgtc  aaagctaag  gtagaagca  gattatgaa  60
tgtccatcg  ctgtgacat  ggacttaga  ttgccacag  atgaagcta  agggaagga  120
accatgtga  aatccaggg  ctgttaggg  tttgtgctt  ccgatgacc  tacctggta  180
gaagtctgt  atcagctct  tcagtttcc  ctgccagct  tgggcctgc  gccccgcct  240
ctctgggtt  ggaacgagg  cttgggtgc  agctagtgg  acctgtgca  aagaactac  300
tctacagac  gtgggaaga  gccagggct  gctgtggct  acaggaagc  tgtgacagc  360
ttgtgtgtg  tggaagcag  gcacatctg  gctggggaa  gctgacagc  gcaacctgt  420
gttctctgg  gggaa  435



<210> 6347
<211> 368
<212> PRT
<213> Rattus norvegicus
<308> P50745
<400> 6347

Met Ala Gly Arg Thr Gln Gly Lys His Arg Pro Arg Val Arg Thr Cys 
  1               5                  10                  15
Pro Ser Leu Val Pro Phe Asp Asn Pro Cys Trp Pro Pro Ser His Gln 
             20                  25                  30
Pro Leu Pro Leu Gln Val Gly Ala Pro Gly His Arg Val Thr Ser Phe 
         35                  40                  45
Leu Ser Gly Arg Ala Trp Pro Ser Tyr Ile Pro Lys Gly Lys His Gly 
     50                  55                  60
Leu Pro Gly Pro Arg Tyr Val Pro Asp Pro Trp Ser Leu Gly Val Leu 
 65                  70                  75                  80
Gly His Val Ala Pro Leu Arg Val Thr Thr Thr Ile Phe Leu Pro Gly 
                 85                  90                  95
Ala Ser Pro Gly Val Met Leu Asp Pro Ala Cys Gln Lys Thr Asp His 
             100                105                110
Phe Leu Ser Cys Tyr Pro Trp Phe His Gly Pro Ile Ser Arg Val Arg 
         115                120                125
Ala Ala Gln Leu Val Gln Leu Gln Gly Pro Asp Ala His Gly Val Phe 
     130                135                140
Leu Val Arg Gln Ser Glu Ser Arg Arg Gly Glu Tyr Val Leu Thr Phe 
 145                150                155                160
Asn Leu Gln Gly Arg Ala Lys His Leu Arg Leu Val Leu Thr Glu Arg 
                 165                170                175
Gly Gln Cys Arg Val Gln His Leu His Phe Pro Ser Val Val Asp Met 
             180                185                190
Leu Arg His Phe Gln Arg Ser Pro Ile Pro Leu Glu Cys Gly Ala Ala 
         195                200                205
Cys Asp Val Arg Leu Ser Gly Tyr Val Val Val Val Ser Gln Ala Pro 
     210                215                220
Gly Arg Lys Pro Lys Val Val Ser Arg Gly Gly Val Thr Ala Ser Thr 
 225                230                235                240
Ala Arg Thr Lys Leu Pro Ser Trp Leu Arg Leu Leu His Gly Val Ile 
                 245                250                255
His Val Ile Ser Pro Gly Ser Ser Asn Thr Val Leu Phe Pro Phe Ser 
             260                265                270
Leu Pro His Trp Asp Ser Glu Leu Gly His Pro His Leu Ser Ser Ala 
         275                280                285
Gly Cys Pro Pro Gly His Gly Ala Glu Ala Leu Arg Gly Gln Val Thr 
     290                295                300
Pro Pro Glu Gln Ile Phe His Leu Val Pro Ser Pro Glu Glu Leu Ala 
 305                310                315                320
Asn Ser Leu Arg Gln Leu Glu Leu Glu Ser Val Ser Ser Ala Arg Asp 
                 325                330                335
Ser Asp Tyr Glu Met Asp Ser Ser Ser Arg Ser His Leu Arg Ala Ile 
             340                345                350
Asp Asn Gln Tyr Thr Pro Leu Ser Gln Leu Cys Arg Glu Ala Asn Leu 
         355                360                365



<210> 6348
<211> 5423
<212> DNA
<213> Homo sapiens
<308> NM_005475
<400> 6348

cccgggcca  cgcctccgc  cggctgccc  cccggactg  cgcggcccg  ggtggcgac  60
gcggccgct  caaagtttc  ccggcggcg  cggcccggg  gcgcatcct  ccgcaactg  120
caagcgctg  cggcggaaa  gatgaggcg  tggccattt  ccgagcccg  gtttcctgc  180
tgagccccg  tcgagcgag  cgcgagcga  gagccggcg  gcgggagag  acgcgccca  240
ggcgggggc  cgcccgccc  ctcgggatt  cgagggccc  ggggcgcgc  acgccatgg  300
ccggccggg  ccagagctc  tgtctctca  cccggccgc  ccacctggg  ctccgccat  360
aacgggcct  ccctgcagc  ctcctcgcc  tcttccgcg  cctcagcct  cccggcggc  420
gccccgcgg  gctggagcg  gttctgtga  ttgcacgcc  tagcggcgg  ccgggagct  480
gcccgccag  actggctgt  cgcccggga  catccgcag  acgcgccgc  gcgcgccga  540
ctggtgtcg  tgcagttca  cgacctctt  cagcgctac  tctgccgcg  ggtgcgcga  600
ggacgggcg  cgggccgcg  ctaccggga  acaggccgt  ggcccccag  caaggccga  660
gcgtccccg  agccaggcc  cggccccgc  gcccctggc  tgcccaagg  ccgcagctc  720
gaggagctg  ccccgccgc  gccgcccgg  ccctgctcc  tccagcact  tcgccgcag  780
ctccgccac  tcttccgcc  ccgctcggc  ggggagctg  cagcggccc  caccgctgc  840
gcccccggg  cccccggag  ggctgctga  acccccgcc  ggcctggcc  ggccaagaa  900
ttcctgccc  ggagcctgg  ccgggagcc  ccacccgag  cgctgaagg  ggcggtgct  960
cgctacagc  tggccgacg  ggcctccat  gacagcggg  cacgctggc  gcgcgggag  1020
ctggcgctg  gccgggccc  gggccccga  ggccccgac  gcgtgctgg  gctcttcga  1080
ccacccaag  gttcaaggc  caagctaca  gcagcttgc  ccagcatcc  ggaggtccg  1140
tggtgcaca  ggcttgaga  gcctgacaa  ctttacacc  ttgtgctga  ggtgaagga  1200
cggacagac  tcatctttg  ggtgggaga  gagcagcag  tgaattcat  gatggctga  1260
ctctcggag  gcacaggcc  agggctgga  agcacagaa  cagagatgc  tattccctc  1320
gccctagag  ctagcacgt  cagctcccc  aggggcagc  cagattccc  taaccaagg  1380
gcttctcct  gggggctgc  ggacccggc  tgccagaag  cggaccatt  cctgtcctg  1440
tacccctgg  tccacggcc  catctccag  gtgaaagca  ctcagctgg  tcagctgca  1500
ggccctgat  ctcatggag  gttcctggt  cggcagagc  agacgcggc  tggggaata  1560
gtgctcact  tcaactttc  ggggatagc  aagcacctg  gcctgtcgc  gacagagcg  1620
ggccagtgc  gtgtgcagc  cctccactt  ccctcggtc  tggacatgc  ccaccactt  1680
cagcgctcg  ccatcccac  cgagtgcgg  gccgcctgt  atgtccggc  ctccagcta  1740
gtggtagtc  tctcccaac  accaggttc  tgcaacacg  tcctcttcc  tttctccct  1800
cctcactgg  attcagagt  ccttcctca  tggggttca  agttgggcc  tccccacct  1860
agttcttct  gctgtcccc  ggggctcag  ccagagggt  tcccagggc  atcctcacc  1920
cccgagcag  tcttccacc  ggtgccttc  cccgaagaa  tggccaaca  cctgcagca  1980
ctggagcat  agcctgtga  tcgagcccg  gactcggac  acgaaatgg  ctcatcctc  2040
cggagccac  tgcgggcca  agacaatca  tacacacct  tctgaccag  gaggaattc  2100
aggcctcaa  agctgccct  gaggagcac  ggcagaagt  tgaacttgt  aatgtaatt  2160
atctttcct  ccttccaga  aaagattta  gggacactg  taactgctc  tgccagttt  2220
gaagtgacc  ttctattag  cctgttgaa  ggccctcct  taggtttca  ctatccacc  2280
ggctttctc  ttattgttt  cagatgtag  tcttgttag  ggatgccgc  agctcctgc  2340
cggggtccc  atgcccagt  cccgttact  ttagagaaa  gagttgggg  gagggccag  2400
gctggcagt  gaaacttgt  ctctttttc  ctgacactg  cacagcgga  gacagactt  2460
ctacgggga  gaggggggg  tcatcagga  gcccagaac  ctaacaagc  gttctccca  2520
ctaccgtca  tccacatgg  aggtctgct  tgtccacac  acagatgac  acatctaat  2580
ctgcttcta  tctcagctt  aggacaaaa  ctctgtcag  ggcacaagc  gaaggtcaa  2640
aatgattta  aacatttta  ctcagacta  tttctttaa  ggattcagg  tcaaaactt  2700
accactgct  atttcagtg  actgtttca  ctaacaccc  tgctatttt  gtagtcaga  2760
acagctatg  aaaccctac  taatttaca  tctgagcca  catgctggc  tgtctactg  2820
atcctcggg  cagtcacct  ccactgagt  gccactgtc  ttcctaaat  tcaagaagt  2880
aagtatgtc  ccctttcag  gaaattcag  caattactg  aataggaag  tggcaagaa  2940
agttctatc  tggtgcctt  cgaataaaa  actggattc  ggtttacag  agctttaca  3000
tgatagtta  attaactgg  gctagggga  aagcaacca  aaagggaaa  aggactcct  3060
ggccctttc  attaaatcc  tcagcaaca  ggctggctt  gtgccctcc  agcatctaa  3120
ggcttatta  attatccca  aattgggtt  taggctcct  ttttgaccc  aaatggaag  3180
tgggaatct  gtgccataa  taatgagaa  ctcctttaa  accccacaa  cagtgttct  3240
ttctacctg  ctactgctt  actggattg  aaatctatc  atctccttg  acacatggg  3300
acacacaat  tccaccatc  agggaggtc  tgaattcaa  tctctatct  tccaagtga  3360
acaattcat  gggggctgg  tcctcccag  acctgtctg  aggctcaga  acgggggca  3420
tgacagtgg  gtcagctgc  cttgggtgc  agcagagcc  ttcagtaca  cccccaggc  3480
cacagcagt  gcttctagg  aactgggag  ttagatcag  tttacagat  catcgatca  3540
aggctaaaa  gaaacctca  cctaaaact  ataggactg  ctgcctggg  ggagggtta  3600
gtctgcttc  tccacttat  cttagtctc  gtgctccaa  aggtcaaat  tttgcttct  3660
gaatttcct  ggggtcttt  agagggtgg  ggaacaaac  cctatgcac  tttcttttt  3720
ttttttgag  tggagtttc  cttgtcaac  gggctggag  gcagtggtg  aatcttggc  3780
cactgcaac  tccaccttc  tggttcaag  gattctgcc  cgacctctc  agtagctgg  3840
attacaagc  ccagccacc  tgcctggct  attttgtat  tttagtaga  acagggttt  3900
accatgttg  ccaggctgg  ctcgaatgt  tgacctcag  tgatccacc  gccttggcc  3960
cccaaagtg  tgggattac  ggcgcgagc  accgcgccc  gcctacacc  cttttagta  4020
caacactct  gggtgattt  atggaccct  aagcagacc  gacactgat  cagatttgc  4080
gtccatttt  aaggacacc  gtctttatt  cctcaaagt  aagcagctt  ctctggaaa  4140
tgaatgcta  ttagtgtga  ccaaaagag  aagtaagag  ctgaagttt  tttaaagga  4200
aaagcttat  atggaaagt  actggtcct  ccctccgca  aggaaaggt  cccagtaga  4260
aatgaacca  attaagttc  ctccctcca  ccagaagtt  aacatctgg  atatgacgt  4320
ttcatgcca  gggcactca  ttcttagca  cctctctac  tacatctct  aggtggtgc  4380
aagaggcac  ccaggtaga  caaacttag  agctctgac  aacaggctg  aaagtgcaa  4440
ttcagattc  gtggcagag  tttggaggg  acccacgtc  agactgctt  ccgtccaag  4500
taccaggac  gctcaaaaa  atgctgaca  aaaactccc  tggctctag  aaaaagtga  4560
actaagcca  cacctttct  tatgtggga  caaaatcag  tgatgaagg  gtgggcacc  4620
ttgtggggc  ggcacccca  tggctgcag  tagcccacc  taggcacag  acatcccac  4680
actctcctt  cagtcctga  caggcccca  ccggcaact  ctaccgaga  ccatggctc  4740
acaccaaac  ggacagtag  catcatgat  cctccagtt  gctctaatt  cagacccca  4800
cagtacagc  tgacagctc  cggcaccat  ccttccttc  tctgactta  tgaactttt  4860
caaactaac  gtcaccagc  ccaaagaat  aagtcaact  acctgcctt  aattttaaa  4920
cagcaatcc  tatggcttt  tctggtata  atcttctgc  tttgatcat  tctggaccg  4980
aggaaaaag  aatagcaat  attaaaatc  tgggccaga  aacactatt  ttacataac  5040
gtttcttaa  ctaaagtca  ggccttgga  tcttccctg  gggttgcct  aaattcctt  5100
atgctttct  ttcaggact  attccctta  tgcaaatgt  ttagctcta  catctccca  5160
aagctaaag  aacttgcaa  tatattaac  aggacacat  tgacatcct  tgtttggtt  5220
aaatataca  cacattgtg  taacataaa  tggatccat  ttgtatcat  ataggcaaa  5280
ggtatttgg  aaattttta  gtatggttt  atgtactgt  caagtaact  attcttgaa  5340
aatgcaaat  ttgctataa  gtacaaatt  ctatatgtg  attaaaaag  ttccaaaat  5400
ttgaaaaaa  aaaaaaaaa  aaa  5423



<210> 6349
<211> 575
<212> PRT
<213> Homo sapiens
<308> Q9UQQ2
<400> 6349

Met Asn Gly Pro Ala Leu Gln Pro Ser Ser Pro Ser Ser Ala Pro Ser 
  1               5                  10                  15
Ala Ser Pro Ala Ala Ala Pro Arg Gly Trp Ser Glu Phe Cys Glu Leu 
             20                  25                  30
His Ala Val Ala Ala Ala Arg Glu Leu Ala Arg Gln Tyr Trp Leu Phe 
         35                  40                  45
Ala Arg Glu His Pro Gln His Ala Pro Leu Arg Ala Glu Leu Val Ser 
     50                  55                  60
Leu Gln Phe Thr Asp Leu Phe Gln Arg Tyr Phe Cys Arg Glu Val Arg 
 65                  70                  75                  80
Asp Gly Arg Ala Pro Gly Arg Asp Tyr Arg Asp Thr Gly Arg Gly Pro 
                 85                  90                  95
Pro Ala Lys Ala Glu Ala Ser Pro Glu Pro Gly Pro Gly Pro Ala Ala 
             100                105                110
Pro Gly Leu Pro Lys Ala Arg Ser Ser Glu Glu Leu Ala Pro Pro Arg 
         115                120                125
Pro Pro Gly Pro Cys Ser Phe Gln His Phe Arg Arg Ser Leu Arg His 
     130                135                140
Ile Phe Arg Arg Arg Ser Ala Gly Glu Leu Pro Ala Ala His Thr Ala 
 145                150                155                160
Ala Ala Pro Gly Thr Pro Gly Glu Ala Ala Glu Thr Pro Ala Arg Pro 
                 165                170                175
Gly Leu Ala Lys Lys Phe Leu Pro Trp Ser Leu Ala Arg Glu Pro Pro 
             180                185                190
Pro Glu Ala Leu Lys Glu Ala Val Leu Arg Tyr Ser Leu Ala Asp Glu 
         195                200                205
Ala Ser Met Asp Ser Gly Ala Arg Trp Gln Arg Gly Arg Leu Ala Leu 
     210                215                220
Arg Arg Ala Pro Gly Pro Asp Gly Pro Asp Arg Val Leu Glu Leu Phe 
 225                230                235                240
Asp Pro Pro Lys Ser Ser Arg Pro Lys Leu Gln Ala Ala Cys Ser Ser 
                 245                250                255
Ile Gln Glu Val Arg Trp Cys Thr Arg Leu Glu Met Pro Asp Asn Leu 
             260                265                270
Tyr Thr Phe Val Leu Lys Val Lys Asp Arg Thr Asp Ile Ile Phe Glu 
         275                280                285
Val Gly Asp Glu Gln Gln Leu Asn Ser Trp Met Ala Glu Leu Ser Glu 
     290                295                300
Cys Thr Gly Arg Gly Leu Glu Ser Thr Glu Ala Glu Met His Ile Pro 
 305                310                315                320
Ser Ala Leu Glu Pro Ser Thr Ser Ser Ser Pro Arg Gly Ser Thr Asp 
                 325                330                335
Ser Leu Asn Gln Gly Ala Ser Pro Gly Gly Leu Leu Asp Pro Ala Cys 
             340                345                350
Gln Lys Thr Asp His Phe Leu Ser Cys Tyr Pro Trp Phe His Gly Pro 
         355                360                365
Ile Ser Arg Val Lys Ala Ala Gln Leu Val Gln Leu Gln Gly Pro Asp 
     370                375                380
Ala His Gly Val Phe Leu Val Arg Gln Ser Glu Thr Arg Arg Gly Glu 
 385                390                395                400
Tyr Val Leu Thr Phe Asn Phe Gln Gly Ile Ala Lys His Leu Arg Leu 
                 405                410                415
Ser Leu Thr Glu Arg Gly Gln Cys Arg Val Gln His Leu His Phe Pro 
             420                425                430
Ser Val Val Asp Met Leu His His Phe Gln Arg Ser Pro Ile Pro Leu 
         435                440                445
Glu Cys Gly Ala Ala Cys Asp Val Arg Leu Ser Ser Tyr Val Val Val 
     450                455                460
Val Ser Gln Pro Pro Gly Ser Cys Asn Thr Val Leu Phe Pro Phe Ser 
 465                470                475                480
Leu Pro His Trp Asp Ser Glu Ser Leu Pro His Trp Gly Ser Glu Leu 
                 485                490                495
Gly Leu Pro His Leu Ser Ser Ser Gly Cys Pro Arg Gly Leu Ser Pro 
             500                505                510
Glu Gly Leu Pro Gly Arg Ser Ser Pro Pro Glu Gln Ile Phe His Leu 
         515                520                525
Val Pro Ser Pro Glu Glu Leu Ala Asn Ser Leu Gln His Leu Glu His 
     530                535                540
Glu Pro Val Asn Arg Ala Arg Asp Ser Asp Tyr Glu Met Asp Ser Ser 
 545                550                555                560
Ser Arg Ser His Leu Arg Ala Ile Asp Asn Gln Tyr Thr Pro Leu 
                 565                570                575



<210> 6350
<211> 520
<212> DNA
<213> Rattus norvegicus
<308> AA943677
<400> 6350

aaaattaca  atgtgatga  ggtggggct  gcagtttta  agaacacag  ttcatcaat  60
tagtaacca  taacaaact  tttagcatt  ctttgtgta  gttttgcct  gagagcatt  120
cttcacagt  atattttag  aaggttagg  actggtcag  ataaaatat  tcccacctt  180
tctattgta  tttgtatgc  aaaatcatc  caatatatc  gcaactata  aattacaaa  240
tttctagaa  ttgctgcat  tctaagtgt  gtagaaaac  ggatctgca  ggtgtctac  300
ataaggtaa  gctgaacgg  acagaagaa  ttcagtcaa  aatgctttc  gataggtcg  360
tctaaatta  tctaacaaa  acaaccaat  gacaaactc  agaatgtat  ttagttttc  420
tcatggaga  gaaattggt  atgagaaga  cattgtaaa  gattacctt  atatttcac  480
ttacatcat  attttggca  ttcatggaa  atttatttct  520



<210> 6351
<211> 2088
<212> DNA
<213> Homo sapiens
<308> AK054981
<400> 6351

ccaaactac  gatgccttg  taaagaaat  catagatac  caaacctca  agagtcgtt  60
ctccaaaga  gccgtgggt  agatatctg  tcatgtgga  atcactgcc  ccccaggaa  120
gggagatca  aaagtcact  taaaagtga  tgctattaa  gacctaaac  ggcagacca  180
agcaatgtt  cgccccttt  tggaagttt  tatactggg  cccaacctt  gagacaaga  240
gagaaaaca  ggcacaaaa  caaaaagca  cacatggtc  ccaaagtac  atgaaacat  300
tcagttcat  ctcggaaag  aaaatcggc  aggggctta  gaacttcat  tctcagtta  360
ggattactg  tttgccaga  aagatcgaa  tatcggaat  acagtcatt  agctacaga  420
catagcaga  aagggaagc  atggggcat  gtatcctct  ctgaaaaat  tctctatgg  480
tgaaactgg  ttgactatc  ttagaatac  ctctcagag  accagtgat  atgtggcta  540
agaatttgt  agacttaaa  ctgaaacaa  atctactga  gagagtgct  gaaacaaac  600
ctgcaagct  aatacataa  tataattgt  tgactactg  atgcatgtg  aaatacatg  660
gaatgttta  ttcactaca  ttcaatgtt  gccagtact  atgtacgat  tctacaagg  720
atgtaaaaa  cctgctgaa  ttttatacc  attctggtc  ttgggaaat  agtgttcca  780
gaagtgcca  aattatgat  taaagtgaa  tatcaagaa  accttttaa  atgtttatt  840
tgtttcttt  cccatttca  attcattaa  cataatttt  aaaaactag  cttttgagt  900
tgcccatca  ttgtctttg  taaatgaga  tatattgcc  atagatcag  aaacattta  960
tactcaatt  ccattttat  tacttacct  attatagat  tcttacaaa  acccttttc  1020
accataact  gaaatgcag  cacttctag  aagcatttg  aattttata  tcgcagata  1080
tgtgatttt  gcatacaca  taaaataga  aaggtggga  atattttct  ctgaccagt  1140
tccaacctt  ctgaaatat  actgtgaag  aatgctgtt  aagcaaact  acataaagc  1200
atgctagag  ttgttaaca  tgtttgata  atattgaca  aactttgtt  tctaaaact  1260
ccaagatca  atcacattt  taaaaatgg  aagttaatg  atttgtcat  tagtgttat  1320
tcttggctt  accatattt  attctttaa  aagtcatta  tggtttaga  atgggatgg  1380
aagtttact  aaaatacct  taagtaact  tattgttaa  atcttccct  tgacagtta  1440
gactctata  tcagttcaa  gctttattt  taaaaatat  caatgatta  tattgaatg  1500
agcattact  tatattgta  tgatgccaa  agtcatgtt  tcatccact  agtgaaaaa  1560
tagtaaaat  aagtcggaa  aaattgctt  aaattttgt  atttgtatt  ataagcccc  1620
aatgcatca  atgcagtag  agaacaatg  aatacagct  ggtacctaa  aatatagct  1680
agttggttt  tgaatataa  acagtttat  aatatgtgc  ttttctgta  tgttatgat  1740
tgacttttt  gagtctatg  caaaatata  ggctgtaaa  cagtacttt  taattataa  1800
ttatggtca  aactgttag  ggactactt  cagaagcag  aacaagagc  tgttatgat  1860
gtgctttgt  aacaagctg  tctaatacg  taagtaaag  acagaagtg  ttagtatca  1920
gactgtcag  accattctg  aactgagta  gaaatcaca  accagtgag  tgagctaat  1980
catgttaaa  tgttaggcc  ctgctttgt  aatgactcc  ctaaatgca  agtgtgatg  2040
gatcctctg  catatgctt  aataaatgg  tgtatattg  gcacatgc  2088



<210> 6352
<211> 136
<212> PRT
<213> Homo sapiens
<308> AK054981
<400> 6352

Met Phe Arg Pro Phe Val Glu Val Cys Ile Leu Gly Pro Asn Leu Gly 
  1               5                  10                  15
Asp Lys Lys Arg Lys Gln Gly Thr Lys Thr Lys Ser Asn Thr Trp Ser 
             20                  25                  30
Pro Lys Tyr Asn Glu Thr Phe Gln Phe Ile Leu Gly Lys Glu Asn Arg 
         35                  40                  45
Pro Gly Ala Tyr Glu Leu His Leu Ser Val Lys Asp Tyr Cys Phe Ala 
     50                  55                  60
Arg Glu Asp Arg Ile Ile Gly Met Thr Val Ile Gln Leu Gln Asn Ile 
 65                  70                  75                  80
Ala Glu Lys Gly Ser Tyr Gly Ala Trp Tyr Pro Leu Leu Lys Asn Ile 
                 85                  90                  95
Ser Met Asp Glu Thr Gly Leu Thr Ile Leu Arg Ile Leu Ser Gln Arg 
             100                105                110
Thr Ser Asp Asp Val Ala Lys Glu Phe Val Arg Leu Lys Ser Glu Thr 
         115                120                125
Arg Ser Thr Glu Glu Ser Ala Ter 
     130                135



<210> 6353
<211> 596
<212> DNA
<213> Rattus norvegicus
<308> AA944177
<400> 6353

cgggcggag  cagccccca  ttcgagcgg  gcttctcct  gcgccgcgg  cgacaaaat  60
ggggcggcg  cgcgagcct  cggccttcc  ggcgcacgt  gcggcctcg  gcccgcccg  120
agccgcagc  cccctctac  tcaggccaa  ttcggaggg  ggggaatcc  ccccgcgcg  180
gccaggaaa  tcaactaaa  atgggcaaa  gagatccta  gaagccgag  ggcaaaatg  240
cctcatatg  attctttgt  caaacctgc  gggaggagc  caagaagaa  cacccggat  300
cttctgtca  cttctcaga  ttctccaag  agtgctcag  gaggtggaa  accatgtct  360
ctaaagaaa  ggggaaatt  gaagatatg  caaaggctg  caaggctcg  tatgaaaga  420
aaatgaaaa  ctacatccc  cccaaaggg  agaccaaaa  gaagttcaa  gaccccaat  480
cccccaaga  gcctccttc  gccttcttc  tgttctgtt  tgagtaccg  ccaaaaatc  540
aaggcgagc  tcctggctt  tccattggt  atgttgcga  gaaactagg  gagatg  596



<210> 6354
<211> 214
<212> PRT
<213> Rattus norvegicus
<308> P07155
<400> 6354

Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
  1               5                  10                  15
Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
             20                  25                  30
Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
         35                  40                  45
Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys 
     50                  55                  60
Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro Pro 
 65                  70                  75                  80
Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg 
                 85                  90                  95
Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys Ile 
             100                105                110
Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu 
         115                120                125
Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu 
     130                135                140
Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
 145                150                155                160
Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys 
                 165                170                175
Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Asp Asp Glu Glu Asp 
             180                185                190
Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Glu 
         195                200                205
Glu Asp Asp Asp Asp Glu 
     210



<210> 6355
<211> 578
<212> DNA
<213> Homo sapiens
<308> AV701053
<400> 6355

cgcagcctt  tgaaaagaa  cctgcgaag  tgaaggaaa  atacgaaaa  gatattgct  60
catatcgag  taaaggaaa  cctgatgca  caaaaaaag  gagttgtca  ggctgaaaa  120
agcaagaaa  agaaggaag  ggaggaaga  gaggaagat  aagaggatg  ggaggagga  180
gaggatgaa  aagattttt  tcttgtcta  aaagcattt  acccccctg  acacaactc  240
ctcctttta  agaaaaaaa  tgaaatgta  ggctgtgta  gatttgttt  taaactgta  300
agtgtcttt  tttgtatag  taacacact  ccgaatgtg  ctttagata  ccctgtcct  360
gtggtattt  caatagcca  taaccttgc  tggtacagt  tgggggttg  aaattggca  420
ggaaattta  agcaggttc  tgttggtgc  cagcacaaa  tagttatat  tggggatgg  480
agttttttc  tcttcagtt  tctctgatg  agcttatac  aaataattg  tgttctgtt  540
actgaatac  actctgtaa  tgcaaaaaa  aaaaaaaa  578



<210> 6356
<211> 214
<212> PRT
<213> Homo sapiens
<308> P09429
<400> 6356

Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
  1               5                  10                  15
Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
             20                  25                  30
Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
         35                  40                  45
Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys 
     50                  55                  60
Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro Pro 
 65                  70                  75                  80
Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg 
                 85                  90                  95
Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys Ile 
             100                105                110
Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu 
         115                120                125
Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu 
     130                135                140
Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
 145                150                155                160
Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys 
                 165                170                175
Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu Asp 
             180                185                190
Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu Glu 
         195                200                205
Glu Asp Asp Asp Asp Glu 
     210



<210> 6357
<211> 559
<212> DNA
<213> Rattus norvegicus
<308> AA944324
<400> 6357

agcaataat  ttcagttta  tagatgaaa  agacttgga  catagtctg  atgaatgca  60
aataagcca  ctacagcaa  tgataagaa  ctgggcaaa  aggaaaaag  catacatgg  120
gggagattc  ctcgaaata  aaaaaaaaa  tcaaaccat  attataaag  actttacca  180
gagttgcta  taccccacc  cgtttgctg  aagtcacaa  agcatatag  actgtattc  240
tgtcaaatg  cagatcaga  catcctaac  caaagccga  aggaaatag  agagggggg  300
taaggggaa  aaagaaaac  cccaacccc  ctaaacggt  gaacagtaa  tcgagttca  360
tttcaaaaa  gagagtggc  attgaaaga  gtgatgatg  tggcgataa  cctatgaat  420
ggtttttga  ttctctcct  ccgggggct  ggtggaggg  gctcattag  atttgtagt  480
agaggttaa  catgtgagc  cctcataga  tccgtcccc  gaggtggca  aggagggct  540
cacatacca  ttcctgtcc  559



<210> 6358
<211> 174
<212> PRT
<213> Rattus norvegicus
<308> P26438
<400> 6358

Gly Lys Val Leu Ser Lys Ile Phe Gly Asn Lys Glu Met Arg Ile Leu 
  1               5                  10                  15
Met Leu Gly Leu Asp Ala Ala Gly Lys Thr Thr Ile Leu Tyr Lys Leu 
             20                  25                  30
Lys Leu Gly Gln Ser Val Thr Thr Ile Pro Thr Val Gly Phe Asn Val 
         35                  40                  45
Glu Thr Val Thr Tyr Lys Asn Val Lys Phe Asn Val Trp Asp Val Gly 
     50                  55                  60
Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His Tyr Tyr Thr Gly Thr 
 65                  70                  75                  80
Gln Gly Leu Ile Phe Val Val Asp Cys Ala Asp Arg Asp Arg Ile Asp 
                 85                  90                  95
Glu Ala Arg Gln Glu Leu His Arg Ile Ile Asn Asp Arg Glu Met Arg 
             100                105                110
Asp Ala Ile Ile Leu Ile Phe Ala Asn Lys Gln Asp Leu Pro Asp Ala 
         115                120                125
Met Lys Pro His Glu Ile Gln Glu Lys Leu Gly Leu Thr Arg Ile Arg 
     130                135                140
Asp Arg Asn Trp Tyr Val Gln Pro Ser Cys Ala Thr Ser Gly Asp Gly 
 145                150                155                160
Leu Tyr Glu Gly Leu Thr Trp Leu Thr Ser Asn Tyr Lys Ser 
                 165                170



<210> 6359
<211> 1194
<212> DNA
<213> Homo sapiens
<308> M57763
<400> 6359

ggccggagg  agcccgcgc  cggggcggc  gctggaggc  gcgcaccga  ttcccgcga  60
gatccatga  ctgacgggg  cccggagcc  cgctgcctc  cgggtgtcc  gggtcggtg  120
ggagcccag  gctcgcagg  cggcgggcg  gccggaggg  tgcagtctc  ctcgcggtg  180
gaggaaggc  gaggagcgg  aaccgcggc  gcgctcgcg  ggcgcctgc  gggggaagg  240
cagttccgg  ccgggccgc  cctcagcag  gcggcggct  ccagcgcag  ctcagggcc  300
gggtggcgg  ggcgactgg  gaaatcaag  tgtgcggtc  gtgatgccc  agtgagcgg  360
gggcctggg  ctctgccct  aggaggcaa  tcccacgca  gccgcaaag  gctctcgcg  420
ccgagaggc  tcgtttcgg  ttcgcggcg  cggcggcgt  gttggctga  gggacccgg  480
acacctgaa  gcccccggc  ccggctcct  cgacgcgat  gggaaggtg  tatccaaaa  540
cttcgggaa  aaggaaatg  ggatcctca  gttgggcct  gacgcggcc  gcaagacaa  600
aatcctgta  aagttgaag  tgggccagt  ggtgaccac  attcccact  tgggtttca  660
cgtggagac  gtgacttac  aaaatgtca  gttcaacgt  tgggatgtg  gcggccagg  720
caagatccg  ccgctctgg  ggcattact  cactgggac  caaggtctc  tcttcgtag  780
ggactgcgc  gaccgcgac  gcatcgatg  ggctcgcca  gagctgcac  gcattatca  840
tgaccggga  atgagggac  ccataatcc  catcttcgc  aacaagcag  acctgcccg  900
tgccatgaa  ccccacgag  tccaggaga  actgggcct  acccggatt  gggacagga  960
ctggtatgt  cagccctcc  gtgccacct  aggggacgg  ctctatgag  ggctcacat  1020
gttaacctc  aactacaaa  cttaatgag  attctccac  catcccctg  aaggagaga  1080
atcaaaaac  cattcatag  attatcgcc  ccatcacct  tttcaattg  cactttctc  1140
tcttttgaa  ttgaactct  gagttactg  tctacagtt  ggcggggac  gggc  1194



<210> 6360
<211> 174
<212> PRT
<213> Homo sapiens
<308> P26438
<400> 6360

Gly Lys Val Leu Ser Lys Ile Phe Gly Asn Lys Glu Met Arg Ile Leu 
  1               5                  10                  15
Met Leu Gly Leu Asp Ala Ala Gly Lys Thr Thr Ile Leu Tyr Lys Leu 
             20                  25                  30
Lys Leu Gly Gln Ser Val Thr Thr Ile Pro Thr Val Gly Phe Asn Val 
         35                  40                  45
Glu Thr Val Thr Tyr Lys Asn Val Lys Phe Asn Val Trp Asp Val Gly 
     50                  55                  60
Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His Tyr Tyr Thr Gly Thr 
 65                  70                  75                  80
Gln Gly Leu Ile Phe Val Val Asp Cys Ala Asp Arg Asp Arg Ile Asp 
                 85                  90                  95
Glu Ala Arg Gln Glu Leu His Arg Ile Ile Asn Asp Arg Glu Met Arg 
             100                105                110
Asp Ala Ile Ile Leu Ile Phe Ala Asn Lys Gln Asp Leu Pro Asp Ala 
         115                120                125
Met Lys Pro His Glu Ile Gln Glu Lys Leu Gly Leu Thr Arg Ile Arg 
     130                135                140
Asp Arg Asn Trp Tyr Val Gln Pro Ser Cys Ala Thr Ser Gly Asp Gly 
 145                150                155                160
Leu Tyr Glu Gly Leu Thr Trp Leu Thr Ser Asn Tyr Lys Ser 
                 165                170



<210> 6361
<211> 542
<212> DNA
<213> Rattus norvegicus
<308> AA944397
<400> 6361

cagcctcat  atcactgac  tccttgtca  gttccttct  cacaaagag  gtaatgggg  60
agccaataa  ctgagaatg  ttcttcaca  tttctttta  tctcctttc  tccaaatac  120
cagtttggt  ttcttttag  tgcaagata  cctttgttc  acgacccat  ggttcacct  180
tgtctgtcc  cacagtgaa  gatcctcca  ctgaggact  ccaggcgta  tgctcgtca  240
cattatgct  ggtgatgac  gtcactttc  cagcaacca  atacgcaga  taaaaacca  300
caccaaact  gccaatcat  gagatatct  caccagcct  caaagcctc  atgaaggct  360
tggtgcctg  cttggcaat  gtgccaagg  tattgatca  gtcagcctt  gtcattcca  420
tgccagtat  cacaatagt  agggttcgg  cttgcttgt  gggaatgag  ttaatgtgc  480
gctccttcc  cgagtccag  ttactaggg  cggtcaagc  ctcgtatct  atcttatcc  540
ga  542



<210> 6362
<211> 733
<212> PRT
<213> Rattus norvegicus
<308> NP_034610
<400> 6362

Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu 
  1               5                  10                  15
Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu 
             20                  25                  30
Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu 
         35                  40                  45
Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu 
     50                  55                  60
Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu 
 65                  70                  75                  80
Ile Pro Ser Lys Gln Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile 
                 85                  90                  95
Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys 
             100                105                110
Ser Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile 
         115                120                125
Ser Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val 
     130                135                140
Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr 
 145                150                155                160
Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr 
                 165                170                175
Gly Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu 
             180                185                190
Asp Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys 
         195                200                205
Lys His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys 
     210                215                220
Glu Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Glu 
 225                230                235                240
Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu Ser Asp Asp Lys Pro 
                 245                250                255
Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Glu Lys Lys Asp 
             260                265                270
Gly Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln 
         275                280                285
Glu Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp 
     290                295                300
Ile Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp 
 305                310                315                320
Trp Glu Glu His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu 
                 325                330                335
Glu Phe Arg Ala Leu Leu Phe Val Pro Arg Arg Ala Pro Phe Asp Leu 
             340                345                350
Phe Glu Asn Arg Lys Lys Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg 
         355                360                365
Val Phe Ile Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn 
     370                375                380
Phe Ile Arg Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser 
 385                390                395                400
Arg Glu Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn 
                 405                410                415
Leu Val Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys 
             420                425                430
Glu Asn Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu 
         435                440                445
Gly Ile His Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu 
     450                455                460
Arg Tyr Tyr Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp 
 465                470                475                480
Tyr Cys Thr Arg Met Lys Glu Asn Gln Lys His Ile Tyr Phe Ile Thr 
                 485                490                495
Gly Glu Thr Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu 
             500                505                510
Arg Lys His Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu 
         515                520                525
Tyr Cys Val Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser 
     530                535                540
Val Thr Lys Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys 
 545                550                555                560
Lys Gln Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu Cys Lys Ile Met 
                 565                570                575
Lys Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn Arg 
             580                585                590
Leu Val Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp Thr 
         595                600                605
Ala Asn Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn Ser 
     610                615                620
Thr Met Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro Asp 
 625                630                635                640
His Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys Asn 
                 645                650                655
Asp Lys Ser Val Lys Asp Leu Val Ile Leu Leu Tyr Glu Thr Ala Leu 
             660                665                670
Leu Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn Arg 
         675                680                685
Ile Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp Pro 
     690                695                700
Thr Val Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro Leu 
 705                710                715                720
Glu Gly Asp Asp Asp Thr Ser Arg Met Glu Glu Val Asp 
                 725                730



<210> 6363
<211> 1063
<212> DNA
<213> Homo sapiens
<308> BE786120
<400> 6363

actgaactg  cggaagata  agagaacta  aagaaattc  atgagcagt  ctctaaaaa  60
ataaagctt  gaatacacg  agactctca  aatcggaag  agctttcag  gctgttaag  120
tactacaca  ctgcctctg  tgatgagat  gtttctctc  aggactact  caccagaat  180
aaggagaac  agaaacata  ctattatat  acaggtgag  ccaaggacc  ggtagctaa  240
tcagccttt  tggaacgtc  tcggaaaca  ggcttagaa  tgatctata  gattgagcc  300
attgatgag  actgtgtcc  acagctgaa  gaatttgag  ggaagactt  agtgtcagt  360
accaaagaa  gcctggaac  tccagagga  gaagaagag  acaaagaag  aggaagaga  420
caaaacaaa  tttgagaac  tctgcaaaa  catgaaaga  atatcggag  aaaaagttg  480
aaaggtggt  gtgtcaaac  gattggtga  atctccatg  tgtattgtc  caagcacat  540
tggctggac  gcaaacact  gagagaatc  tgaaagctc  agccctaag  gacaactca  600
caatgggtt  catggccag  aagacacac  tggcagata  accctgacc  ttcatcatc  660
agaccttag  cacaaggca  acggctgat  acaacgacc  gcctgacaa  gcacagggc  720
aacctggcc  cgatgaaca  tgcgcccac  gaacagcag  gcatcaaga  tggaagaat  780
ccaagacac  gctacccag  acctcaccg  gcacacccc  ctcgggacc  cgaacatga  840
agacagaaa  gcctacacg  atctgacaa  aaaggcgac  atgacacca  caacaggca  900
accagtacc  agcatacag  cacgatcac  agtgaagaa  aaataaaac  caccgcgag  960
cagcacacc  cagacacac  cacacaagc  acgaaacac  aaccagccg  cacccatcc  1020
ccacacgac  catcagcag  gccacaaca  cgaccgcta  aca  1063



<210> 6364
<211> 731
<212> PRT
<213> Homo sapiens
<308> CAA30255
<400> 6364

Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu Val 
  1               5                  10                  15
Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile 
             20                  25                  30
Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile 
         35                  40                  45
Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Thr Leu Thr 
     50                  55                  60
Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu Ile 
 65                  70                  75                  80
Pro Asn Lys Gln Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile Gly 
                 85                  90                  95
Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser 
             100                105                110
Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser 
         115                120                125
Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala 
     130                135                140
Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala 
 145                150                155                160
Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr Gly 
                 165                170                175
Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp 
             180                185                190
Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys Lys 
         195                200                205
His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys Glu 
     210                215                220
Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp Lys 
 225                230                235                240
Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro Glu 
                 245                250                255
Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly Asp 
             260                265                270
Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu Glu 
         275                280                285
Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile Thr 
     290                295                300
Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp Glu 
 305                310                315                320
Asp His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu Glu Phe 
                 325                330                335
Arg Ala Leu Leu Phe Val Pro Arg Arg Ala Pro Phe Asp Leu Phe Glu 
             340                345                350
Asn Arg Lys Lys Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg Val Phe 
         355                360                365
Ile Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe Ile 
     370                375                380
Arg Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg Glu 
 385                390                395                400
Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu Val 
                 405                410                415
Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu Asn 
             420                425                430
Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly Ile 
         435                440                445
His Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg Tyr 
     450                455                460
Tyr Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr Cys 
 465                470                475                480
Thr Arg Met Lys Glu Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly Glu 
                 485                490                495
Thr Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Arg Lys 
             500                505                510
His Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr Cys 
         515                520                525
Val Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser Val Thr 
     530                535                540
Lys Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys Gln 
 545                550                555                560
Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu Cys Lys Ile Met Lys Asp 
                 565                570                575
Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn Arg Leu Val 
             580                585                590
Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala Asn 
         595                600                605
Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr Met 
     610                615                620
Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro Asp His Ser 
 625                630                635                640
Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp Lys 
                 645                650                655
Ser Val Lys Asp Leu Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu Ser 
             660                665                670
Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn Arg Ile Tyr 
         675                680                685
Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr Ala 
     690                695                700
Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro Leu Glu Gly 
 705                710                715                720
Asp Asp Asp Thr Ser Arg Met Glu Glu Val Asp 
                 725                730



<210> 6365
<211> 542
<212> DNA
<213> Rattus norvegicus
<308> AA944397
<400> 6365

cagcctcat  atcactgac  tccttgtca  gttccttct  cacaaagag  gtaatgggg  60
agccaataa  ctgagaatg  ttcttcaca  tttctttta  tctcctttc  tccaaatac  120
cagtttggt  ttcttttag  tgcaagata  cctttgttc  acgacccat  ggttcacct  180
tgtctgtcc  cacagtgaa  gatcctcca  ctgaggact  ccaggcgta  tgctcgtca  240
cattatgct  ggtgatgac  gtcactttc  cagcaacca  atacgcaga  taaaaacca  300
caccaaact  gccaatcat  gagatatct  caccagcct  caaagcctc  atgaaggct  360
tggtgcctg  cttggcaat  gtgccaagg  tattgatca  gtcagcctt  gtcattcca  420
tgccagtat  cacaatagt  agggttcgg  cttgcttgt  gggaatgag  ttaatgtgc  480
gctccttcc  cgagtccag  ttactaggg  cggtcaagc  ctcgtatct  atcttatcc  540
ga  542



<210> 6366
<211> 733
<212> PRT
<213> Rattus norvegicus
<308> NP_034610
<400> 6366

Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu 
  1               5                  10                  15
Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu 
             20                  25                  30
Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu 
         35                  40                  45
Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu 
     50                  55                  60
Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu 
 65                  70                  75                  80
Ile Pro Ser Lys Gln Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile 
                 85                  90                  95
Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys 
             100                105                110
Ser Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile 
         115                120                125
Ser Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val 
     130                135                140
Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr 
 145                150                155                160
Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr 
                 165                170                175
Gly Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu 
             180                185                190
Asp Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys 
         195                200                205
Lys His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys 
     210                215                220
Glu Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Glu 
 225                230                235                240
Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu Ser Asp Asp Lys Pro 
                 245                250                255
Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Glu Lys Lys Asp 
             260                265                270
Gly Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln 
         275                280                285
Glu Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp 
     290                295                300
Ile Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp 
 305                310                315                320
Trp Glu Glu His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu 
                 325                330                335
Glu Phe Arg Ala Leu Leu Phe Val Pro Arg Arg Ala Pro Phe Asp Leu 
             340                345                350
Phe Glu Asn Arg Lys Lys Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg 
         355                360                365
Val Phe Ile Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn 
     370                375                380
Phe Ile Arg Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser 
 385                390                395                400
Arg Glu Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn 
                 405                410                415
Leu Val Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys 
             420                425                430
Glu Asn Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu 
         435                440                445
Gly Ile His Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu 
     450                455                460
Arg Tyr Tyr Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp 
 465                470                475                480
Tyr Cys Thr Arg Met Lys Glu Asn Gln Lys His Ile Tyr Phe Ile Thr 
                 485                490                495
Gly Glu Thr Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu 
             500                505                510
Arg Lys His Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu 
         515                520                525
Tyr Cys Val Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser 
     530                535                540
Val Thr Lys Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys 
 545                550                555                560
Lys Gln Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu Cys Lys Ile Met 
                 565                570                575
Lys Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn Arg 
             580                585                590
Leu Val Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp Thr 
         595                600                605
Ala Asn Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn Ser 
     610                615                620
Thr Met Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro Asp 
 625                630                635                640
His Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys Asn 
                 645                650                655
Asp Lys Ser Val Lys Asp Leu Val Ile Leu Leu Tyr Glu Thr Ala Leu 
             660                665                670
Leu Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn Arg 
         675                680                685
Ile Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp Pro 
     690                695                700
Thr Val Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro Leu 
 705                710                715                720
Glu Gly Asp Asp Asp Thr Ser Arg Met Glu Glu Val Asp 
                 725                730



<210> 6367
<211> 1063
<212> DNA
<213> Homo sapiens
<308> BE786120
<400> 6367

actgaactg  cggaagata  agagaacta  aagaaattc  atgagcagt  ctctaaaaa  60
ataaagctt  gaatacacg  agactctca  aatcggaag  agctttcag  gctgttaag  120
tactacaca  ctgcctctg  tgatgagat  gtttctctc  aggactact  caccagaat  180
aaggagaac  agaaacata  ctattatat  acaggtgag  ccaaggacc  ggtagctaa  240
tcagccttt  tggaacgtc  tcggaaaca  ggcttagaa  tgatctata  gattgagcc  300
attgatgag  actgtgtcc  acagctgaa  gaatttgag  ggaagactt  agtgtcagt  360
accaaagaa  gcctggaac  tccagagga  gaagaagag  acaaagaag  aggaagaga  420
caaaacaaa  tttgagaac  tctgcaaaa  catgaaaga  atatcggag  aaaaagttg  480
aaaggtggt  gtgtcaaac  gattggtga  atctccatg  tgtattgtc  caagcacat  540
tggctggac  gcaaacact  gagagaatc  tgaaagctc  agccctaag  gacaactca  600
caatgggtt  catggccag  aagacacac  tggcagata  accctgacc  ttcatcatc  660
agaccttag  cacaaggca  acggctgat  acaacgacc  gcctgacaa  gcacagggc  720
aacctggcc  cgatgaaca  tgcgcccac  gaacagcag  gcatcaaga  tggaagaat  780
ccaagacac  gctacccag  acctcaccg  gcacacccc  ctcgggacc  cgaacatga  840
agacagaaa  gcctacacg  atctgacaa  aaaggcgac  atgacacca  caacaggca  900
accagtacc  agcatacag  cacgatcac  agtgaagaa  aaataaaac  caccgcgag  960
cagcacacc  cagacacac  cacacaagc  acgaaacac  aaccagccg  cacccatcc  1020
ccacacgac  catcagcag  gccacaaca  cgaccgcta  aca  1063



<210> 6368
<211> 731
<212> PRT
<213> Homo sapiens
<308> CAA30255
<400> 6368

Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu Val 
  1               5                  10                  15
Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile 
             20                  25                  30
Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile 
         35                  40                  45
Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Thr Leu Thr 
     50                  55                  60
Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu Ile 
 65                  70                  75                  80
Pro Asn Lys Gln Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile Gly 
                 85                  90                  95
Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser 
             100                105                110
Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser 
         115                120                125
Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala 
     130                135                140
Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala 
 145                150                155                160
Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr Gly 
                 165                170                175
Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp 
             180                185                190
Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys Lys 
         195                200                205
His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys Glu 
     210                215                220
Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp Lys 
 225                230                235                240
Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro Glu 
                 245                250                255
Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly Asp 
             260                265                270
Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu Glu 
         275                280                285
Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile Thr 
     290                295                300
Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp Glu 
 305                310                315                320
Asp His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu Glu Phe 
                 325                330                335
Arg Ala Leu Leu Phe Val Pro Arg Arg Ala Pro Phe Asp Leu Phe Glu 
             340                345                350
Asn Arg Lys Lys Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg Val Phe 
         355                360                365
Ile Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe Ile 
     370                375                380
Arg Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg Glu 
 385                390                395                400
Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu Val 
                 405                410                415
Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu Asn 
             420                425                430
Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly Ile 
         435                440                445
His Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg Tyr 
     450                455                460
Tyr Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr Cys 
 465                470                475                480
Thr Arg Met Lys Glu Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly Glu 
                 485                490                495
Thr Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Arg Lys 
             500                505                510
His Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr Cys 
         515                520                525
Val Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser Val Thr 
     530                535                540
Lys Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys Gln 
 545                550                555                560
Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu Cys Lys Ile Met Lys Asp 
                 565                570                575
Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn Arg Leu Val 
             580                585                590
Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala Asn 
         595                600                605
Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr Met 
     610                615                620
Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro Asp His Ser 
 625                630                635                640
Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp Lys 
                 645                650                655
Ser Val Lys Asp Leu Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu Ser 
             660                665                670
Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn Arg Ile Tyr 
         675                680                685
Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr Ala 
     690                695                700
Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro Leu Glu Gly 
 705                710                715                720
Asp Asp Asp Thr Ser Arg Met Glu Glu Val Asp 
                 725                730



<210> 6369
<211> 445
<212> DNA
<213> Rattus norvegicus
<308> AA945054
<400> 6369

actttacaa  ccagatata  tttaaaaag  tcatgttta  aataggtaa  ttacgtagt  60
aagaaatgt  aaaatgaag  tgagtaaca  aggcacatt  gaaagttta  gagtacaaa  120
agtcccatg  ttgttctcc  agcatagga  gaaagggag  cagatatat  acaattaca  180
tctcagggg  agggtttct  tcagtggaa  tgattaaca  tggcttctt  tctcccctc  240
ctggggcag  cttttcctt  cttggcttc  gacagacag  ttaaccttc  gccatgtag  300
ggcgataca  cagagctac  accatggct  agatggctg  gatcaccca  ttggtccac  360
aactggaat  agactcgac  gtagtgata  gggtttctg  actttgcca  gacagcttg  420
gaatttggc  tctgacaga  tccca  445



<210> 6370
<211> 133
<212> PRT
<213> Rattus norvegicus
<308> P00173
<400> 6370

Ala Glu Gln Ser Asp Lys Asp Val Lys Tyr Tyr Thr Leu Glu Glu Ile 
  1               5                  10                  15
Gln Lys His Lys Asp Ser Lys Ser Thr Trp Val Ile Leu His His Lys 
             20                  25                  30
Val Tyr Asp Leu Thr Lys Phe Leu Glu Glu His Pro Gly Gly Glu Glu 
         35                  40                  45
Val Leu Arg Glu Gln Ala Gly Gly Asp Ala Thr Glu Asn Phe Glu Asp 
     50                  55                  60
Val Gly His Ser Thr Asp Ala Arg Glu Leu Ser Lys Thr Tyr Ile Ile 
 65                  70                  75                  80
Gly Glu Leu His Pro Asp Asp Arg Ser Lys Ile Ala Lys Pro Ser Glu 
                 85                  90                  95
Thr Leu Ile Thr Thr Val Glu Ser Asn Ser Ser Trp Trp Thr Asn Trp 
             100                105                110
Val Ile Pro Ala Ile Ser Ala Leu Val Val Ala Leu Met Tyr Arg Leu 
         115                120                125
Tyr Met Ala Glu Asp 
     130



<210> 6371
<211> 445
<212> DNA
<213> Rattus norvegicus
<308> AA945054
<400> 6371

actttacaa  ccagatata  tttaaaaag  tcatgttta  aataggtaa  ttacgtagt  60
aagaaatgt  aaaatgaag  tgagtaaca  aggcacatt  gaaagttta  gagtacaaa  120
agtcccatg  ttgttctcc  agcatagga  gaaagggag  cagatatat  acaattaca  180
tctcagggg  agggtttct  tcagtggaa  tgattaaca  tggcttctt  tctcccctc  240
ctggggcag  cttttcctt  cttggcttc  gacagacag  ttaaccttc  gccatgtag  300
ggcgataca  cagagctac  accatggct  agatggctg  gatcaccca  ttggtccac  360
aactggaat  agactcgac  gtagtgata  gggtttctg  actttgcca  gacagcttg  420
gaatttggc  tctgacaga  tccca  445



<210> 6372
<211> 133
<212> PRT
<213> Rattus norvegicus
<308> P00173
<400> 6372

Ala Glu Gln Ser Asp Lys Asp Val Lys Tyr Tyr Thr Leu Glu Glu Ile 
  1               5                  10                  15
Gln Lys His Lys Asp Ser Lys Ser Thr Trp Val Ile Leu His His Lys 
             20                  25                  30
Val Tyr Asp Leu Thr Lys Phe Leu Glu Glu His Pro Gly Gly Glu Glu 
         35                  40                  45
Val Leu Arg Glu Gln Ala Gly Gly Asp Ala Thr Glu Asn Phe Glu Asp 
     50                  55                  60
Val Gly His Ser Thr Asp Ala Arg Glu Leu Ser Lys Thr Tyr Ile Ile 
 65                  70                  75                  80
Gly Glu Leu His Pro Asp Asp Arg Ser Lys Ile Ala Lys Pro Ser Glu 
                 85                  90                  95
Thr Leu Ile Thr Thr Val Glu Ser Asn Ser Ser Trp Trp Thr Asn Trp 
             100                105                110
Val Ile Pro Ala Ile Ser Ala Leu Val Val Ala Leu Met Tyr Arg Leu 
         115                120                125
Tyr Met Ala Glu Asp 
     130



<210> 6373
<211> 472
<212> DNA
<213> Rattus norvegicus
<308> AA945583
<400> 6373

agatttgag  atttattag  cacagaggg  gaatggagc  gagttacaa  gtggctgtt  60
ggtttcctt  aaactgaaa  ggagccggt  tttttcctg  cttggcctt  taaggctgc  120
ttcgaatgg  cccatccag  cggatgacc  ctccattca  gaatgggtt  tcgattacc  180
tctgtacca  atgagcata  tccgcgggg  cacctaatc  gctggggaa  ggtacctgt  240
tggccaaga  gttgcgcac  ttgtctggc  cagtggtaa  caatggggt  gcaaacaga  300
ctggagcaa  tgttaccac  cgggtgcct  aaggagcca  atctccagc  atgggcagt  360
tcatgccca  taagccccc  ttggatgca  agtatgcag  ttgtccaac  tggccctca  420
aagcagcca  actgggaat  ttaatgata  ctccacgtt  acctccctg  tc  472



<210> 6374
<211> 260
<212> PRT
<213> Rattus norvegicus
<308> O70351
<400> 6374

Ala Ala Ala Val Arg Ser Val Lys Gly Leu Val Ala Val Ile Thr Gly 
  1               5                  10                  15
Gly Ala Ser Gly Leu Gly Leu Ser Thr Ala Lys Arg Leu Val Gly Gln 
             20                  25                  30
Gly Ala Thr Ala Val Leu Leu Asp Val Pro Asn Ser Glu Gly Glu Thr 
         35                  40                  45
Glu Ala Lys Lys Leu Gly Gly Asn Cys Ile Phe Ala Pro Ala Asn Val 
     50                  55                  60
Thr Ser Glu Lys Glu Val Gln Ala Ala Leu Thr Leu Ala Lys Glu Lys 
 65                  70                  75                  80
Phe Gly Arg Ile Asp Val Ala Val Asn Cys Ala Gly Ile Ala Val Ala 
                 85                  90                  95
Ile Lys Thr Tyr His Glu Lys Lys Asn Gln Val His Thr Leu Glu Asp 
             100                105                110
Phe Gln Arg Val Ile Asn Val Asn Leu Ile Gly Thr Phe Asn Val Ile 
         115                120                125
Arg Leu Val Ala Gly Val Met Gly Gln Asn Glu Pro Asp Gln Gly Gly 
     130                135                140
Gln Arg Gly Val Ile Ile Asn Thr Ala Ser Val Ala Ala Phe Glu Gly 
 145                150                155                160
Gln Val Gly Gln Ala Ala Tyr Ser Ala Ser Lys Gly Gly Ile Val Gly 
                 165                170                175
Met Thr Leu Pro Ile Ala Arg Asp Leu Ala Pro Ile Gly Ile Arg Val 
             180                185                190
Val Thr Ile Ala Pro Gly Leu Phe Ala Thr Pro Leu Leu Thr Thr Leu 
         195                200                205
Pro Asp Lys Val Arg Asn Phe Leu Ala Ser Gln Val Pro Phe Pro Ser 
     210                215                220
Arg Leu Gly Asp Pro Ala Glu Tyr Ala His Leu Val Gln Met Val Ile 
 225                230                235                240
Glu Asn Pro Phe Leu Asn Gly Glu Val Ile Arg Leu Asp Gly Ala Ile 
                 245                250                255
Arg Met Gln Pro 
             260



<210> 6375
<211> 965
<212> DNA
<213> Homo sapiens
<308> BC008708
<400> 6375

ccggcgaca  gatggcagc  gcgtgtcgg  gcgtgaagg  cctggtggc  gtaataacc  60
gaggagcct  gggcctggg  ctggccacg  cggagcgac  tgtggggca  ggagcctct  120
ctgtgcttc  ggacctgcc  aactcgggt  gggaggccc  agccaagaa  ttaggaaac  180
actgcgttt  cgccccagc  gacgtgacc  ctgagaagg  tgtgcaaac  gctctggct  240
tagcaaaag  aaagtttgg  cgtgtggat  tagctgtca  ctgtgcagg  atcgcggtg  300
ctagcaaga  gtacaactt  aagaagggc  agacccata  cttggaaga  ttccagcga  360
ttcttgatg  gaatctcat  ggcaccttc  atgtgatcc  cctggtggc  ggtgagatg  420
gccagaatg  accagacca  ggaggccaa  gtggggtca  catcaacac  gccagtgtg  480
ctgccttcg  gggtcaggt  ggacaagct  catactctg  ttccaaggg  ggaatagtg  540
gcatgacac  gcccattgc  cgggatctg  ctcccatag  tctgtttgg  accccactg  600
tgaccagcc  cccagagaa  gtgtgcaac  tcttggcca  ccaagtgcc  ttccctagc  660
gactgggtg  ccctgctga  tatgctcac  tcgtacagg  catcatcga  aacccattc  720
tcaatggag  ggtcatccg  ctggatggg  ccattcgta  gcagccttg  agggagaag  780
cagagaaaa  acacgctcc  ctgcccttc  tttccctgg  gtactactc  ccagcttgg  840
aggaagccc  gtagccatt  tgtaactgc  taccagtcg  cctctgtgc  taataaagt  900
tctttttct  acaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  960
aaaac  965



<210> 6376
<211> 261
<212> PRT
<213> Homo sapiens
<308> Q99714
<400> 6376

Met Ala Ala Ala Cys Arg Ser Val Lys Gly Leu Val Ala Val Ile Thr 
  1               5                  10                  15
Gly Gly Ala Ser Gly Leu Gly Leu Ala Thr Ala Glu Arg Leu Val Gly 
             20                  25                  30
Gln Gly Ala Ser Ala Val Leu Leu Asp Leu Pro Asn Ser Gly Gly Glu 
         35                  40                  45
Ala Gln Ala Lys Lys Leu Gly Asn Asn Cys Val Phe Ala Pro Ala Asp 
     50                  55                  60
Val Thr Ser Glu Lys Asp Val Gln Thr Ala Leu Ala Leu Ala Lys Gly 
 65                  70                  75                  80
Lys Phe Gly Arg Val Asp Val Ala Val Asn Cys Ala Gly Ile Ala Val 
                 85                  90                  95
Ala Ser Lys Thr Tyr Asn Leu Lys Lys Gly Gln Thr His Thr Leu Glu 
             100                105                110
Asp Phe Gln Arg Val Leu Asp Val Asn Leu Met Gly Thr Phe Asn Val 
         115                120                125
Ile Arg Leu Val Ala Gly Glu Met Gly Gln Asn Glu Pro Asp Gln Gly 
     130                135                140
Gly Gln Arg Gly Val Ile Ile Asn Thr Ala Ser Val Ala Ala Phe Glu 
 145                150                155                160
Gly Gln Val Gly Gln Ala Ala Tyr Ser Ala Ser Lys Gly Gly Ile Val 
                 165                170                175
Gly Met Thr Leu Pro Ile Ala Arg Asp Leu Ala Pro Ile Gly Ile Arg 
             180                185                190
Val Met Thr Ile Ala Pro Gly Leu Phe Gly Thr Pro Leu Leu Thr Ser 
         195                200                205
Leu Pro Glu Lys Val Cys Asn Phe Leu Ala Ser Gln Val Pro Phe Pro 
     210                215                220
Ser Arg Leu Gly Asp Pro Ala Glu Tyr Ala His Leu Val Gln Ala Ile 
 225                230                235                240
Ile Glu Asn Pro Phe Leu Asn Gly Glu Val Ile Arg Leu Asp Gly Ala 
                 245                250                255
Ile Arg Met Gln Pro 
             260



<210> 6377
<211> 472
<212> DNA
<213> Rattus norvegicus
<308> AA945583
<400> 6377

agatttgag  atttattag  cacagaggg  gaatggagc  gagttacaa  gtggctgtt  60
ggtttcctt  aaactgaaa  ggagccggt  tttttcctg  cttggcctt  taaggctgc  120
ttcgaatgg  cccatccag  cggatgacc  ctccattca  gaatgggtt  tcgattacc  180
tctgtacca  atgagcata  tccgcgggg  cacctaatc  gctggggaa  ggtacctgt  240
tggccaaga  gttgcgcac  ttgtctggc  cagtggtaa  caatggggt  gcaaacaga  300
ctggagcaa  tgttaccac  cgggtgcct  aaggagcca  atctccagc  atgggcagt  360
tcatgccca  taagccccc  ttggatgca  agtatgcag  ttgtccaac  tggccctca  420
aagcagcca  actgggaat  ttaatgata  ctccacgtt  acctccctg  tc  472



<210> 6378
<211> 260
<212> PRT
<213> Rattus norvegicus
<308> O70351
<400> 6378

Ala Ala Ala Val Arg Ser Val Lys Gly Leu Val Ala Val Ile Thr Gly 
  1               5                  10                  15
Gly Ala Ser Gly Leu Gly Leu Ser Thr Ala Lys Arg Leu Val Gly Gln 
             20                  25                  30
Gly Ala Thr Ala Val Leu Leu Asp Val Pro Asn Ser Glu Gly Glu Thr 
         35                  40                  45
Glu Ala Lys Lys Leu Gly Gly Asn Cys Ile Phe Ala Pro Ala Asn Val 
     50                  55                  60
Thr Ser Glu Lys Glu Val Gln Ala Ala Leu Thr Leu Ala Lys Glu Lys 
 65                  70                  75                  80
Phe Gly Arg Ile Asp Val Ala Val Asn Cys Ala Gly Ile Ala Val Ala 
                 85                  90                  95
Ile Lys Thr Tyr His Glu Lys Lys Asn Gln Val His Thr Leu Glu Asp 
             100                105                110
Phe Gln Arg Val Ile Asn Val Asn Leu Ile Gly Thr Phe Asn Val Ile 
         115                120                125
Arg Leu Val Ala Gly Val Met Gly Gln Asn Glu Pro Asp Gln Gly Gly 
     130                135                140
Gln Arg Gly Val Ile Ile Asn Thr Ala Ser Val Ala Ala Phe Glu Gly 
 145                150                155                160
Gln Val Gly Gln Ala Ala Tyr Ser Ala Ser Lys Gly Gly Ile Val Gly 
                 165                170                175
Met Thr Leu Pro Ile Ala Arg Asp Leu Ala Pro Ile Gly Ile Arg Val 
             180                185                190
Val Thr Ile Ala Pro Gly Leu Phe Ala Thr Pro Leu Leu Thr Thr Leu 
         195                200                205
Pro Asp Lys Val Arg Asn Phe Leu Ala Ser Gln Val Pro Phe Pro Ser 
     210                215                220
Arg Leu Gly Asp Pro Ala Glu Tyr Ala His Leu Val Gln Met Val Ile 
 225                230                235                240
Glu Asn Pro Phe Leu Asn Gly Glu Val Ile Arg Leu Asp Gly Ala Ile 
                 245                250                255
Arg Met Gln Pro 
             260



<210> 6379
<211> 965
<212> DNA
<213> Homo sapiens
<308> BC008708
<400> 6379

ccggcgaca  gatggcagc  gcgtgtcgg  gcgtgaagg  cctggtggc  gtaataacc  60
gaggagcct  gggcctggg  ctggccacg  cggagcgac  tgtggggca  ggagcctct  120
ctgtgcttc  ggacctgcc  aactcgggt  gggaggccc  agccaagaa  ttaggaaac  180
actgcgttt  cgccccagc  gacgtgacc  ctgagaagg  tgtgcaaac  gctctggct  240
tagcaaaag  aaagtttgg  cgtgtggat  tagctgtca  ctgtgcagg  atcgcggtg  300
ctagcaaga  gtacaactt  aagaagggc  agacccata  cttggaaga  ttccagcga  360
ttcttgatg  gaatctcat  ggcaccttc  atgtgatcc  cctggtggc  ggtgagatg  420
gccagaatg  accagacca  ggaggccaa  gtggggtca  catcaacac  gccagtgtg  480
ctgccttcg  gggtcaggt  ggacaagct  catactctg  ttccaaggg  ggaatagtg  540
gcatgacac  gcccattgc  cgggatctg  ctcccatag  tctgtttgg  accccactg  600
tgaccagcc  cccagagaa  gtgtgcaac  tcttggcca  ccaagtgcc  ttccctagc  660
gactgggtg  ccctgctga  tatgctcac  tcgtacagg  catcatcga  aacccattc  720
tcaatggag  ggtcatccg  ctggatggg  ccattcgta  gcagccttg  agggagaag  780
cagagaaaa  acacgctcc  ctgcccttc  tttccctgg  gtactactc  ccagcttgg  840
aggaagccc  gtagccatt  tgtaactgc  taccagtcg  cctctgtgc  taataaagt  900
tctttttct  acaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  960
aaaac  965



<210> 6380
<211> 261
<212> PRT
<213> Homo sapiens
<308> Q99714
<400> 6380

Met Ala Ala Ala Cys Arg Ser Val Lys Gly Leu Val Ala Val Ile Thr 
  1               5                  10                  15
Gly Gly Ala Ser Gly Leu Gly Leu Ala Thr Ala Glu Arg Leu Val Gly 
             20                  25                  30
Gln Gly Ala Ser Ala Val Leu Leu Asp Leu Pro Asn Ser Gly Gly Glu 
         35                  40                  45
Ala Gln Ala Lys Lys Leu Gly Asn Asn Cys Val Phe Ala Pro Ala Asp 
     50                  55                  60
Val Thr Ser Glu Lys Asp Val Gln Thr Ala Leu Ala Leu Ala Lys Gly 
 65                  70                  75                  80
Lys Phe Gly Arg Val Asp Val Ala Val Asn Cys Ala Gly Ile Ala Val 
                 85                  90                  95
Ala Ser Lys Thr Tyr Asn Leu Lys Lys Gly Gln Thr His Thr Leu Glu 
             100                105                110
Asp Phe Gln Arg Val Leu Asp Val Asn Leu Met Gly Thr Phe Asn Val 
         115                120                125
Ile Arg Leu Val Ala Gly Glu Met Gly Gln Asn Glu Pro Asp Gln Gly 
     130                135                140
Gly Gln Arg Gly Val Ile Ile Asn Thr Ala Ser Val Ala Ala Phe Glu 
 145                150                155                160
Gly Gln Val Gly Gln Ala Ala Tyr Ser Ala Ser Lys Gly Gly Ile Val 
                 165                170                175
Gly Met Thr Leu Pro Ile Ala Arg Asp Leu Ala Pro Ile Gly Ile Arg 
             180                185                190
Val Met Thr Ile Ala Pro Gly Leu Phe Gly Thr Pro Leu Leu Thr Ser 
         195                200                205
Leu Pro Glu Lys Val Cys Asn Phe Leu Ala Ser Gln Val Pro Phe Pro 
     210                215                220
Ser Arg Leu Gly Asp Pro Ala Glu Tyr Ala His Leu Val Gln Ala Ile 
 225                230                235                240
Ile Glu Asn Pro Phe Leu Asn Gly Glu Val Ile Arg Leu Asp Gly Ala 
                 245                250                255
Ile Arg Met Gln Pro 
             260



<210> 6381
<211> 520
<212> DNA
<213> Rattus norvegicus
<308> AA945704
<400> 6381

caggtttag  atcagtctt  aatgctgtc  cactgcata  tgacaagtc  cacactttg  60
tcttgtgtt  gtagtggca  cttacaatg  gtcgaatgg  cagagcacc  ggctagctc  120
aaagaacag  tccattccc  ccccaggtc  gactcatca  agccctgga  aggcagtag  180
tgacaggga  tgctttcat  caagtgcac  ccagctttg  atggaatta  aaaaacata  240
ttacatacg  tccacggtg  tcctttcat  agaagcaaa  gccctttta  caaaaggga  300
tatatctag  gctgtgcaa  attcaaaag  actgtatcc  tttgagaaa  ttgagtcca  360
tacacacac  catacacac  cacaaaaaa  gtcacctgc  cctctgaga  gtgccaggt  420
tggccaagg  ctacctctg  accagcaag  actgtgact  taaggcagc  atctgattt  480
aagagagcc  caggtccag  ggatctcct  gctgtccagg  520



<210> 6382
<211> 340
<212> PRT
<213> Rattus norvegicus
<308> BAA95672
<400> 6382

Met Gly Lys Asp Tyr Tyr Gln Thr Leu Gly Leu Ala Arg Gly Ala Ser 
  1               5                  10                  15
Asp Asp Glu Ile Lys Arg Ala Tyr Arg Arg Gln Ala Leu Arg Tyr His 
             20                  25                  30
Pro Asp Lys Asn Lys Glu Pro Gly Ala Glu Glu Lys Phe Lys Glu Ile 
         35                  40                  45
Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Arg Lys Arg Glu Ile Phe 
     50                  55                  60
Asp Arg Tyr Gly Glu Glu Gly Leu Lys Gly Gly Ser Pro Ser Gly Gly 
 65                  70                  75                  80
Ser Ser Gly Gly Ala Asn Gly Thr Ser Phe Ser Tyr Thr Phe His Gly 
                 85                  90                  95
Asp Pro His Ala Met Phe Ala Glu Phe Phe Gly Gly Arg Asn Pro Phe 
             100                105                110
Asp Thr Phe Phe Gly Gln Arg Asn Gly Glu Glu Gly Met Asp Ile Asp 
         115                120                125
Asp Thr Phe Ser Ser Phe Pro Met Gly Met Gly Gly Phe Thr Asn Met 
     130                135                140
Asn Phe Gly Arg Ser Arg Pro Ser Gln Glu Pro Thr Arg Lys Lys Gln 
 145                150                155                160
Asp Pro Pro Val Thr His Asp Leu Arg Val Ser Leu Glu Glu Ile Tyr 
                 165                170                175
Ser Gly Cys Thr Lys Lys Met Lys Ile Ser His Lys Arg Leu Asn Pro 
             180                185                190
Asp Gly Lys Ser Ile Arg Asn Glu Asp Lys Ile Leu Thr Ile Glu Val 
         195                200                205
Lys Arg Gly Trp Lys Glu Gly Thr Lys Ile Thr Phe Pro Lys Glu Gly 
     210                215                220
Asp Gln Thr Ser Asn Asn Ile Pro Ala Asp Ile Val Phe Val Leu Lys 
 225                230                235                240
Asp Lys Pro His Asn Ile Phe Lys Arg Asp Gly Ser Asp Val Ile Tyr 
                 245                250                255
Pro Ala Arg Ile Ser Leu Arg Glu Ala Leu Cys Gly Cys Thr Val Asn 
             260                265                270
Val Pro Thr Leu Asp Gly Arg Thr Ile Pro Val Val Phe Lys Asp Val 
         275                280                285
Ile Arg Pro Gly Met Arg Arg Lys Val Pro Gly Glu Gly Leu Pro Leu 
     290                295                300
Pro Lys Thr Pro Glu Lys Arg Gly Asp Leu Val Ile Glu Phe Glu Val 
 305                310                315                320
Ile Phe Pro Glu Arg Ile Pro Val Ser Ser Arg Thr Ile Leu Glu Gln 
                 325                330                335
Val Leu Pro Ile 
             340



<210> 6383
<211> 454
<212> DNA
<213> Rattus norvegicus
<308> AA946040
<400> 6383

aacctttcc  gtgagtttt  attagtagt  gcatcatga  tcagggtcc  agggtaggg  60
ccatcatat  ctgaggtcc  ccttttcta  cggggagaa  gtcaaagag  agaggagag  120
tgggcggag  caggtcaga  cttcccagg  aatgtgcct  ctgctatgc  gtcatccca  180
gctgagacc  atgagacgg  gcagaggga  ttgtacact  gccggtacc  ctcgcacac  240
gagacgtca  cgccctttg  cgtcattgc  ttctcacag  ggtggaagt  caggtagtt  300
tgccagcag  tcttagtct  gttctggtt  gggaagcgg  tgtcaaagg  ggcggtttt  360
tagttcttg  ttttagtct  gatgtcttc  gccatcctg  ctcctaaag  ctgtcccgg  420
gcagcgtta  ttcaatgtg  ccctttgca  agac  454



<210> 6384
<211> 85
<212> PRT
<213> Rattus norvegicus
<308> P56391
<400> 6384

Ala Glu Asp Ile Lys Thr Lys Ile Lys Asn Tyr Lys Thr Ala Pro Phe 
  1               5                  10                  15
Asp Ser Arg Phe Pro Asn Gln Asn Gln Thr Lys Asn Cys Trp Gln Asn 
             20                  25                  30
Tyr Leu Asp Phe His Arg Cys Glu Lys Ala Met Thr Ala Lys Gly Gly 
         35                  40                  45
Asp Val Ser Val Cys Glu Trp Tyr Arg Arg Val Tyr Lys Ser Leu Cys 
     50                  55                  60
Pro Val Ser Trp Val Ser Ala Trp Asp Asp Arg Ile Ala Glu Gly Thr 
 65                  70                  75                  80
Phe Pro Gly Lys Ile 
                 85



<210> 6385
<211> 1007
<212> DNA
<213> Homo sapiens
<308> AL528775
<400> 6385

agggtcaca  tgagctgca  gttgaatcc  gggtgcctt  aggattcag  accatggcg  60
aagacatgg  gaccaaaat  aagaactac  agaccgccc  ttttgacag  cgcttcccc  120
accagaacc  gactagaaa  tgctggcag  actacctgg  cttccaccg  tgtcagaag  180
aggtgacag  ggtggtctc  ttcctggaa  atctcttgt  tttgcaact  tggagctgc  240
gatgttcat  ttagtacgg  atatgccac  tctcagtac  aaggtgtca  actctccaa  300
tcacatagc  actaawact  gactatcag  agaaagtgc  cgtttggtg  cagccacag  360
taccatact  tctgattta  catcccttt  ttcacccgc  ggatgtatg  caatcctgc  420
cacaattct  ttcttaatt  cwagaatat  gawagacac  gcaataaag  ctgcagata  480
tcaggttcc  ccaccagtc  gtgcagctc  tcaagggat  aadagtatt  tgacacttt  540
aatggccaa  actgaggct  gcgttcaaa  acagtggac  gctctgatt  gtagcacgc  600
tgcttgcat  ctggaatat  ctcaaccag  ctctgtacc  acacctgat  aagtaagca  660
gctaacagc  attgcactc  tcctgtggt  tgctagtaa  gaaataata  gagtccagt  720
attacagaa  ggctgcatg  acagattta  aaatgcatt  aattcatgc  acccatggg  780
tcaagccaa  tgttaccag  ttctcctct  agtcttcca  cattccaat  gtgcccttt  840
aactcctta  attcattca  tagctccaa  agtggttga  aagctaaaa  ctgttgaaa  900
aaacagacc  gccagtaac  tagagcttt  agcggttca  gaaggaata  aagttcttg  960
aacactggt  gctcttggt  argacaaac  gagtcagct  cttgctc  1007



<210> 6386
<211> 454
<212> DNA
<213> Rattus norvegicus
<308> AA946040
<400> 6386

aacctttcc  gtgagtttt  attagtagt  gcatcatga  tcagggtcc  agggtaggg  60
ccatcatat  ctgaggtcc  ccttttcta  cggggagaa  gtcaaagag  agaggagag  120
tgggcggag  caggtcaga  cttcccagg  aatgtgcct  ctgctatgc  gtcatccca  180
gctgagacc  atgagacgg  gcagaggga  ttgtacact  gccggtacc  ctcgcacac  240
gagacgtca  cgccctttg  cgtcattgc  ttctcacag  ggtggaagt  caggtagtt  300
tgccagcag  tcttagtct  gttctggtt  gggaagcgg  tgtcaaagg  ggcggtttt  360
tagttcttg  ttttagtct  gatgtcttc  gccatcctg  ctcctaaag  ctgtcccgg  420
gcagcgtta  ttcaatgtg  ccctttgca  agac  454



<210> 6387
<211> 85
<212> PRT
<213> Rattus norvegicus
<308> P56391
<400> 6387

Ala Glu Asp Ile Lys Thr Lys Ile Lys Asn Tyr Lys Thr Ala Pro Phe 
  1               5                  10                  15
Asp Ser Arg Phe Pro Asn Gln Asn Gln Thr Lys Asn Cys Trp Gln Asn 
             20                  25                  30
Tyr Leu Asp Phe His Arg Cys Glu Lys Ala Met Thr Ala Lys Gly Gly 
         35                  40                  45
Asp Val Ser Val Cys Glu Trp Tyr Arg Arg Val Tyr Lys Ser Leu Cys 
     50                  55                  60
Pro Val Ser Trp Val Ser Ala Trp Asp Asp Arg Ile Ala Glu Gly Thr 
 65                  70                  75                  80
Phe Pro Gly Lys Ile 
                 85



<210> 6388
<211> 1007
<212> DNA
<213> Homo sapiens
<308> AL528775
<400> 6388

agggtcaca  tgagctgca  gttgaatcc  gggtgcctt  aggattcag  accatggcg  60
aagacatgg  gaccaaaat  aagaactac  agaccgccc  ttttgacag  cgcttcccc  120
accagaacc  gactagaaa  tgctggcag  actacctgg  cttccaccg  tgtcagaag  180
aggtgacag  ggtggtctc  ttcctggaa  atctcttgt  tttgcaact  tggagctgc  240
gatgttcat  ttagtacgg  atatgccac  tctcagtac  aaggtgtca  actctccaa  300
tcacatagc  actaawact  gactatcag  agaaagtgc  cgtttggtg  cagccacag  360
taccatact  tctgattta  catcccttt  ttcacccgc  ggatgtatg  caatcctgc  420
cacaattct  ttcttaatt  cwagaatat  gawagacac  gcaataaag  ctgcagata  480
tcaggttcc  ccaccagtc  gtgcagctc  tcaagggat  aadagtatt  tgacacttt  540
aatggccaa  actgaggct  gcgttcaaa  acagtggac  gctctgatt  gtagcacgc  600
tgcttgcat  ctggaatat  ctcaaccag  ctctgtacc  acacctgat  aagtaagca  660
gctaacagc  attgcactc  tcctgtggt  tgctagtaa  gaaataata  gagtccagt  720
attacagaa  ggctgcatg  acagattta  aaatgcatt  aattcatgc  acccatggg  780
tcaagccaa  tgttaccag  ttctcctct  agtcttcca  cattccaat  gtgcccttt  840
aactcctta  attcattca  tagctccaa  agtggttga  aagctaaaa  ctgttgaaa  900
aaacagacc  gccagtaac  tagagcttt  agcggttca  gaaggaata  aagttcttg  960
aacactggt  gctcttggt  argacaaac  gagtcagct  cttgctc  1007



<210> 6389
<211> 658
<212> DNA
<213> Rattus norvegicus
<308> AA946368
<400> 6389

gaatttaag  acatcttta  tgttagaaa  cagttattt  tgggtgatt  taaaagcag  60
atatattac  acaaataca  atttaaagc  aattctagc  tttgtaaga  tctatatca  120
aatccattt  ttataaatt  catctttta  cactataac  gctctctga  gttacatta  180
ttgtggctg  gcagaaaga  aaaaaccta  tcagttttc  aaagagcta  gcagcctgg  240
acttgacaa  atacttaaa  taaagagct  aaatgtgct  aaaatagtt  atttcatgg  300
gaggaacag  acatataag  tctgtgtaa  aaagtaaaa  gaaaaaaat  tctgtgata  360
ctggccttg  tgttgccaa  gacaccaga  agggagagg  ttaaacaat  tattagcaa  420
ggttcatat  tgaattgtt  atttttcat  cttaaatct  taaaatgat  taatactta  480
gacatatca  gtgctgaca  tcacaagga  catttgcta  aaatgaaag  gtcacccca  540
acatgataa  agtttactt  gatgaggaa  aaagcgttt  ttagaatat  tacattctt  600
aaatttgcc  acangaaaa  aaaatcagt  aatcagaac  aaagaagat  attagttc  658



<210> 6390
<211> 471
<212> PRT
<213> Rattus norvegicus
<308> Q07969
<400> 6390

Gly Cys Asp Arg Asn Cys Gly Leu Ile Thr Gly Ala Val Ile Gly Ala 
  1               5                  10                  15
Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu Leu 
             20                  25                  30
Ile Glu Lys Thr Ile Lys Arg Glu Val Val Leu Glu Glu Gly Thr Ile 
         35                  40                  45
Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Thr Val Tyr Arg Gln Phe 
     50                  55                  60
Trp Val Phe Asp Val Gln Asn Pro Glu Glu Val Ala Lys Asn Ser Ser 
 65                  70                  75                  80
Lys Ile Lys Val Ile Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg Tyr 
                 85                  90                  95
Leu Ala Lys Glu Asn Ile Thr Gln Asp Pro Lys Asp Ser Thr Val Ser 
             100                105                110
Phe Val Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val Gly 
         115                120                125
Thr Glu Asn Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala Ala 
     130                135                140
Pro His Ile Tyr Thr Asn Ser Phe Val Gln Gly Val Leu Asn Ser Leu 
 145                150                155                160
Ile Lys Lys Ser Lys Ser Ser Met Phe Gln Thr Arg Ser Leu Lys Glu 
                 165                170                175
Leu Leu Trp Gly Tyr Lys Asp Pro Phe Leu Ser Leu Val Pro Tyr Pro 
             180                185                190
Ile Ser Thr Thr Val Gly Val Phe Tyr Pro Tyr Asn Asn Thr Val Asp 
         195                200                205
Gly Val Tyr Lys Val Ser Asn Gly Lys Asp Asn Ile Ser Lys Val Ala 
     210                215                220
Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu Ser 
 225                230                235                240
Tyr Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro Leu 
                 245                250                255
Gly Glu Lys Ser Arg Thr Leu Arg Phe Phe Ser Ser Asp Ile Cys Arg 
             260                265                270
Ser Ile Tyr Ala Val Phe Glu Ser Glu Val Asn Leu Lys Gly Ile Pro 
         275                280                285
Val Tyr Arg Phe Val Leu Pro Ala Asn Ala Phe Ala Ser Pro Leu Gln 
     290                295                300
Asn Pro Asp Asn His Cys Phe Cys Thr Glu Lys Val Ile Ser Asn Asn 
 305                310                315                320
Cys Thr Ser Tyr Gly Val Leu Asp Ile Gly Lys Cys Lys Glu Gly Lys 
                 325                330                335
Pro Val Tyr Asn Ser Leu Pro His Phe Leu His Ala Ser Pro Asp Val 
             340                345                350
Ser Glu Pro Ile Glu Gly Leu Asn Pro Thr Glu Asp Glu His Arg Thr 
         355                360                365
Tyr Leu Asp Val Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ser Lys 
     370                375                380
Arg Leu Gln Val Asn Ile Leu Val Lys Pro Ala Arg Lys Ile Glu Ala 
 385                390                395                400
Leu Lys Asn Leu Lys Arg Pro Tyr Ile Val Pro Ile Leu Trp Leu Asn 
                 405                410                415
Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Glu Met Phe Arg Asn Gln 
             420                425                430
Val Thr Gly Lys Ile Lys Leu Leu Gly Leu Val Glu Met Val Leu Leu 
         435                440                445
Gly Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys Ala 
     450                455                460
Cys Arg Ser Lys Asn Gly Lys 
 465                470



<210> 6391
<211> 1749
<212> DNA
<213> Homo sapiens
<308> BC008406
<400> 6391

gaggactgc  gtgtaggac  ttcctgcag  ataccattt  atcctatta  gaattgtcc  60
aatgttgga  catttgatt  aaaaatcct  cttagccat  ttaaagata  ctttccaat  120
attagacga  ttgattctt  ctgtgactc  tcagttcat  tcctgtaaa  ttcatgtct  180
gctgttgat  tgtgaataa  aaccagagc  tgtagaaac  actttaatc  tatccagga  240
tttgcaaga  acaggtgct  aacactaat  cacctcctg  acaagaaaa  tgggctgtg  300
ccggaactg  gggctcatc  ctggggctg  cattggtgc  gtcctggct  tgtttggag  360
tattctaat  ccagttgga  acctgctta  ccagaagac  attaaaaag  aagttgtcc  420
cgaagaagg  acaattgct  ttaaaaatt  ggttaaaac  ggcacagaa  tttacagac  480
gttttggat  tttgatgtg  aaaatccac  ggaagtgat  atgaacagc  gcaacattc  540
agttaagca  agaggtcct  atacgtaca  agttcgttt  ctagccaag  aaaatgtaa  600
ccaggacgc  gaggacaac  cagtctctt  cctgcagcc  aatggtgcc  tcttcgaac  660
ttcactatc  gttggaaca  aggctgaca  cttcacagt  ctcaatctg  ctgtggcag  720
tgcatccca  atctatcaa  atcaatttg  tcaaatgat  ctcaattca  ttattaaca  780
gtcaaaatc  tctatgttc  aagtcagaa  tttgagaga  ctgttatgg  gctataggg  840
tccattttt  agtttggtt  cataccctg  tactaccac  gttggtctg  tttatcctt  900
caacaatac  gcagatgga  tttataaag  tttcaatgg  aaagataac  taagtaaag  960
tgccataat  gacacatat  aaggtaaaa  gaatctgtc  tattgggaa  gtcactgcg  1020
catgattaa  ggtacagat  cagcctcat  tccaccttt  gttgagaaa  gccaggtat  1080
gcagttctt  tcttctgat  tttgcaggt  aatctatgc  gtatttgaa  ccgacgtta  1140
tctgaaagg  atccctgtg  atagatttg  tcttccatc  aaggccttt  cctctccag  1200
tgaaaaccc  gacaactat  gtttctgca  agaaaaaat  atctcaaaa  attgtacat  1260
atatggtgt  ctagacatc  gcaaatgca  agaagggag  cctgtgtac  tttcacttc  1320
tcattttct  tatgcaagt  ctgatgttt  agaacctat  gatggatta  acccaaatg  1380
agaagaaca  aggacatac  tggatattg  acctataac  ggattcact  tacaatttg  1440
aaaacggct  caggtcaac  tattggtca  gccatcaga  aaaattcaa  tattaaaga  1500
tctgaagag  aactatatt  tgcctattc  ttggcttaa  gagactggg  ccattggtg  1560
tgagaaggc  aacatgttc  gaagtcaag  aactggaaa  ataaacctc  ttggcctga  1620
agaaatgat  ttactcagt  ttggtgtgg  gatgtttgt  gcttttatg  tttcatatt  1680
tgcatgcag  tcgaaaaca  taaaataag  aagtatgta  caaaaaaaa  aaaaaaaaa  1740
aaaaaaaaa  1749



<210> 6392
<211> 471
<212> PRT
<213> Homo sapiens
<308> P16671
<400> 6392

Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly Ala 
  1               5                  10                  15
Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu Leu 
             20                  25                  30
Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr Ile 
         35                  40                  45
Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln Phe 
     50                  55                  60
Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser Ser 
 65                  70                  75                  80
Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg Phe 
                 85                  90                  95
Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val Ser 
             100                105                110
Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val Gly 
         115                120                125
Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala Ala 
     130                135                140
Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser Leu 
 145                150                155                160
Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg Glu 
                 165                170                175
Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr Pro 
             180                185                190
Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala Asp 
         195                200                205
Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val Ala 
     210                215                220
Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu Ser 
 225                230                235                240
His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro Phe 
                 245                250                255
Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys Arg 
             260                265                270
Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile Pro 
         275                280                285
Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val Glu 
     290                295                300
Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys Asn 
 305                310                315                320
Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly Arg 
                 325                330                335
Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp Val 
             340                345                350
Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg Thr 
         355                360                365
Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala Lys 
     370                375                380
Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln Val 
 385                390                395                400
Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu Asn 
                 405                410                415
Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser Gln 
             420                425                430
Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu Leu 
         435                440                445
Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys Ala 
     450                455                460
Cys Arg Ser Lys Thr Ile Lys 
 465                470



<210> 6393
<211> 616
<212> DNA
<213> Rattus norvegicus
<308> AA946439
<400> 6393

atgttgcat  gtgacttta  tgtgggttt  caaacctga  caccagtcc  cattcaggt  60
cgctttgtc  tataggaac  cgaagcttc  actttaact  gaagagcat  cgaggctgt  120
ccctacaac  cctaatggg  cccttgcag  ctggcacgc  acattaaac  cctccgtta  180
cataatcag  ttggcatac  agaaaattc  ttcgcacag  ccgaccaga  acagcattc  240
gagcgctta  cagttggtg  gtggagcca  cacacctag  cctccaatg  gaaagtgca  300
agaagagac  tagtttgca  acgagacaa  gcaacgcta  taattgtag  ccgtaacct  360
gccagcata  taagagttc  cagctcatt  ttgatggtt  gggggccct  aaaagggcc  420
ttgtgagtg  gggaggggg  caaggagaa  gcctataca  acgaggacg  cgatcaacc  480
ccggagcca  agagcgtgc  gccctggcg  ttgagcgca  acaccacgt  catagccgt  540
accgtattg  gcttggcgt  ctcggtgta  gtgacagca  cgcgaatca  attttcaag  600
aaaaccttt  tgacgc  616



<210> 6394
<211> 102
<212> PRT
<213> Rattus norvegicus
<308> P02304
<400> 6394

Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys 
  1               5                  10                  15
Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys Pro 
             20                  25                  30
Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser Gly 
         35                  40                  45
Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu Asn 
     50                  55                  60
Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys Thr 
 65                  70                  75                  80
Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg Thr 
                 85                  90                  95
Leu Tyr Gly Phe Gly Gly 
             100



<210> 6395
<211> 367
<212> DNA
<213> Homo sapiens
<308> NM_003539
<400> 6395

atgtctggc  gcggtaagg  cggaaaggg  ctaggtaag  gtggcgcca  gcgtcaccg  60
aaggtattg  gtgacaata  ccaaggaat  accaagccc  ctatccgcc  cctggctcg  120
cgcggcggc  tcaagcgta  ttctggcct  atttatgag  aaactcgcg  agtgctgaa  180
gttttcctg  aaaatgtaa  ccgcgatgc  gtcacctac  cggaacacg  caaacgcaa  240
acagtcaca  ccatggacg  ggtgtacgc  ctcaagcgc  agggacgca  tctttatgg  300
ttcggcggc  gagcttacc  ctacagtac  ctaccgcaa  accaacggc  cttttcagg  360
ccaccta  367



<210> 6396
<211> 102
<212> PRT
<213> Homo sapiens
<308> P02304
<400> 6396

Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys 
  1               5                  10                  15
Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys Pro 
             20                  25                  30
Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser Gly 
         35                  40                  45
Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu Asn 
     50                  55                  60
Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys Thr 
 65                  70                  75                  80
Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg Thr 
                 85                  90                  95
Leu Tyr Gly Phe Gly Gly 
             100



<210> 6397
<211> 535
<212> DNA
<213> Rattus norvegicus
<308> AA946532
<400> 6397

cttgcggcc  catgtgttt  ttttttttt  ttttttttt  ttgtgcccc  tggtagtgg  60
aaccaaacc  atcacaatg  tttattgga  catattcca  catcacagg  tagcattta  120
taaacagtg  cggatttct  tagctgcta  atttattct  attcctcat  cataccttg  180
ggtgcattt  attccagga  agccatttg  gttttcttt  gctaaataa  aaatgtacc  240
gtctcagtc  tttggactg  gtcgttctg  aggctctcg  gtggacagc  gtgtgtgca  300
tcgtgctta  agcccgtgc  tgctccaca  ggtaccagt  ttaccagtg  ttgagagct  360
agacacacc  tgctgcatg  agttggagg  ctcgggagg  ttttagatt  tgtgacggg  420
accggaaag  ctcgtcaga  tgtggctgt  tcatggtga  caccacgtg  ctgtagagg  480
ctgacatga  gtaatgcac  gagcacaca  cgccactgc  gctgtctgt  gctgt  535



<210> 6398
<211> 658
<212> PRT
<213> Rattus norvegicus
<308> P16970
<400> 6398

Ala Ala Phe Ser Lys Tyr Leu Thr Ala Arg Asn Ser Ser Leu Ala Gly 
  1               5                  10                  15
Ala Ala Phe Leu Leu Phe Cys Leu Leu His Lys Arg Arg Arg Ala Leu 
             20                  25                  30
Gly Leu His Gly Lys Lys Ser Gly Lys Pro Pro Leu Gln Asn Asn Glu 
         35                  40                  45
Lys Glu Gly Lys Lys Glu Arg Ala Val Val Asp Lys Val Phe Leu Ser 
     50                  55                  60
Arg Leu Ser Gln Ile Leu Lys Ile Met Val Pro Arg Thr Phe Cys Lys 
 65                  70                  75                  80
Glu Thr Gly Tyr Leu Ile Leu Ile Ala Val Met Leu Val Ser Arg Thr 
                 85                  90                  95
Tyr Cys Asp Val Trp Met Ile Gln Asn Gly Thr Leu Ile Glu Ser Gly 
             100                105                110
Ile Ile Gly Arg Ser Ser Lys Asp Phe Lys Arg Tyr Leu Phe Asn Phe 
         115                120                125
Ile Ala Ala Met Pro Leu Ile Ser Leu Val Asn Asn Phe Leu Lys Tyr 
     130                135                140
Gly Leu Asn Glu Leu Lys Leu Cys Phe Arg Val Arg Leu Thr Arg Tyr 
 145                150                155                160
Leu Tyr Glu Glu Tyr Leu Gln Ala Phe Thr Tyr Tyr Lys Met Gly Asn 
                 165                170                175
Leu Asp Asn Arg Ile Ala Asn Pro Asp Gln Leu Leu Thr Gln Asp Val 
             180                185                190
Glu Lys Phe Cys Asn Ser Val Val Asp Leu Tyr Ser Asn Leu Ser Lys 
         195                200                205
Pro Phe Leu Asp Ile Val Leu Tyr Ile Phe Lys Leu Thr Ser Ala Ile 
     210                215                220
Gly Ala Gln Gly Pro Ala Ser Met Met Ala Tyr Leu Leu Val Ser Gly 
 225                230                235                240
Leu Phe Leu Thr Arg Leu Arg Arg Pro Ile Gly Lys Met Thr Ile Met 
                 245                250                255
Glu Gln Lys Tyr Glu Gly Glu Tyr Arg Phe Val Asn Ser Arg Leu Ile 
             260                265                270
Thr Asn Ser Glu Glu Ile Ala Phe Tyr Asn Gly Asn Lys Arg Glu Lys 
         275                280                285
Gln Thr Ile His Ser Val Phe Arg Lys Leu Val Glu His Leu His Asn 
     290                295                300
Phe Ile Phe Phe Arg Phe Ser Met Gly Phe Ile Asp Ser Ile Ile Ala 
 305                310                315                320
Lys Tyr Ile Ala Thr Val Val Gly Tyr Leu Val Val Ser Arg Pro Phe 
                 325                330                335
Leu Asp Leu Ala His Pro Arg His Leu His Ser Thr His Ser Glu Leu 
             340                345                350
Leu Glu Asp Tyr Tyr Gln Ser Gly Arg Met Leu Leu Arg Met Ser Gln 
         355                360                365
Ala Leu Gly Arg Ile Val Leu Ala Gly Arg Glu Met Thr Arg Leu Ala 
     370                375                380
Gly Phe Thr Ala Arg Ile Thr Glu Leu Met Gln Val Leu Lys Asp Leu 
 385                390                395                400
Asn His Gly Lys Tyr Glu Arg Thr Met Val Ser Gln Gln Asp Lys Gly 
                 405                410                415
Ile Glu Gly Ala Gln Ala Ser Pro Leu Ile Pro Gly Ala Gly Glu Ile 
             420                425                430
Ile Asn Ala Asp Asn Ile Ile Lys Phe Asp His Val Pro Leu Ala Thr 
         435                440                445
Pro Asn Gly Asp Ile Leu Ile Gln Asp Leu Ser Phe Glu Val Arg Ser 
     450                455                460
Gly Ala Asn Val Leu Ile Cys Gly Pro Asn Gly Cys Gly Lys Ser Ser 
 465                470                475                480
Leu Phe Arg Val Leu Gly Glu Leu Trp Pro Leu Phe Gly Gly His Leu 
                 485                490                495
Thr Lys Pro Glu Arg Gly Lys Leu Phe Tyr Val Pro Gln Arg Pro Tyr 
             500                505                510
Met Thr Leu Gly Thr Leu Arg Asp Gln Val Ile Tyr Pro Asp Gly Lys 
         515                520                525
Glu Asp Gln Lys Lys Lys Gly Ile Ser Asp Gln Val Leu Lys Gly Tyr 
     530                535                540
Leu Asp Asn Val Gln Leu Gly His Ile Leu Glu Arg Glu Gly Gly Trp 
 545                550                555                560
Asp Ser Val Gln Asp Trp Met Asp Val Leu Ser Gly Gly Glu Lys Gln 
                 565                570                575
Arg Met Ala Met Ala Arg Leu Phe Tyr His Lys Pro Gln Phe Ala Ile 
             580                585                590
Leu Asp Glu Cys Thr Ser Ala Val Ser Val Asp Val Glu Asp Tyr Ile 
         595                600                605
Tyr Ser His Cys Arg Lys Val Gly Ile Thr Leu Phe Thr Val Ser His 
     610                615                620
Arg Lys Ser Leu Trp Lys His His Glu Tyr Tyr Leu His Met Asp Gly 
 625                630                635                640
Arg Gly Asn Tyr Glu Phe Lys Lys Ile Thr Glu Asp Thr Val Glu Phe 
                 645                650                655
Gly Ser 
             660



<210> 6399
<211> 949
<212> DNA
<213> Homo sapiens
<308> BC009712
<400> 6399

cggacgcgt  ggcggacgc  tgggtcgcc  gctcgctgg  accggcagt  ccatggcgg  60
cttcagcaa  tacttgacg  cgcgaaact  ctcgctggc  ggtgccgcg  tcctgctgc  120
ctgcctgct  cacaagcgg  gccgcgccc  cggcctgca  ggtaagaaa  gtggaaaac  180
accattaca  aacaatgag  aagagggga  aaaggagcg  gctgtggtg  acaaggtgt  240
tttctcaag  ctcatacag  ttctgaaaa  catggtccc  agaacattt  gtaaagaga  300
aggttactt  gtacttatt  ctgttatgc  ggtgtctcg  acatattgt  atgtttgga  360
gattcaaaa  gggacacta  ttgaaagtg  tatcattgg  cgtagcagg  aagatttca  420
gagatactt  ctcaacttc  tcgctgcca  gcctcttat  tctctggtt  ataacttct  480
gaagtatgg  ttaaatgag  ttaaactgt  cttccgagt  aggctcact  aatacctct  540
tgaggagta  cttcaagct  tcacatatt  taaaatggg  aatctggac  acagaatag  600
taatccaga  cagctgctt  cacaagatg  agaaaaatt  tgtaacagt  tagtcgatc  660
gtattcaaa  cttagtaag  catttttag  catagtttt  tatatcttt  agttaacga  720
tgcaattgg  gctcaggta  ttggaaaaa  tttgtggca  taaaaacca  acaaatgta  780
tggccaggc  tggtggctc  tgcctgtaa  cccagcact  tgggaggct  agatgggag  840
atcgcttga  tccaggagt  cgagacaag  ctggacaaa  agcgagacc  gcttcttta  900
aaaataata  taaaacaga  gttcttaaa  catgaaaaa  aaaaaaaaa  949



<210> 6400
<211> 659
<212> PRT
<213> Homo sapiens
<308> P28288
<400> 6400

Met Ala Ala Phe Ser Lys Tyr Leu Thr Ala Arg Asn Ser Ser Leu Ala 
  1               5                  10                  15
Gly Ala Ala Phe Leu Leu Leu Cys Leu Leu His Lys Arg Arg Arg Ala 
             20                  25                  30
Leu Gly Leu His Gly Lys Lys Ser Gly Lys Pro Pro Leu Gln Asn Asn 
         35                  40                  45
Glu Lys Glu Gly Lys Lys Glu Arg Ala Val Val Asp Lys Val Phe Phe 
     50                  55                  60
Ser Arg Leu Ile Gln Ile Leu Lys Ile Met Val Pro Arg Thr Phe Cys 
 65                  70                  75                  80
Lys Glu Thr Gly Tyr Leu Val Leu Ile Ala Val Met Leu Val Ser Arg 
                 85                  90                  95
Thr Tyr Cys Asp Val Trp Met Ile Gln Asn Gly Thr Leu Ile Glu Ser 
             100                105                110
Gly Ile Ile Gly Arg Ser Arg Lys Asp Phe Lys Arg Tyr Leu Leu Asn 
         115                120                125
Phe Ile Ala Ala Met Pro Leu Ile Ser Leu Val Asn Asn Phe Leu Lys 
     130                135                140
Tyr Gly Leu Asn Glu Leu Lys Leu Cys Phe Arg Val Arg Leu Thr Lys 
 145                150                155                160
Tyr Leu Tyr Glu Glu Tyr Leu Gln Ala Phe Thr Tyr Tyr Lys Met Gly 
                 165                170                175
Asn Leu Asp Asn Arg Ile Ala Asn Pro Asp Gln Leu Leu Thr Gln Asp 
             180                185                190
Val Glu Lys Phe Cys Asn Ser Val Val Asp Leu Tyr Ser Asn Leu Ser 
         195                200                205
Lys Pro Phe Leu Asp Ile Val Leu Tyr Ile Phe Lys Leu Thr Ser Ala 
     210                215                220
Ile Gly Ala Gln Gly Pro Ala Ser Met Met Ala Tyr Leu Val Val Ser 
 225                230                235                240
Gly Leu Phe Leu Thr Arg Leu Arg Arg Pro Ile Gly Lys Met Thr Ile 
                 245                250                255
Thr Glu Gln Lys Tyr Glu Gly Glu Tyr Arg Tyr Val Asn Ser Arg Leu 
             260                265                270
Ile Thr Asn Ser Glu Glu Ile Ala Phe Tyr Asn Gly Asn Lys Arg Glu 
         275                280                285
Lys Gln Thr Val His Ser Val Phe Arg Lys Leu Val Glu His Leu His 
     290                295                300
Asn Phe Ile Leu Phe Arg Phe Ser Met Gly Phe Ile Asp Ser Ile Ile 
 305                310                315                320
Ala Lys Tyr Leu Ala Thr Val Val Gly Tyr Leu Val Val Ser Arg Pro 
                 325                330                335
Phe Leu Asp Leu Ser His Pro Arg His Leu Lys Ser Thr His Ser Glu 
             340                345                350
Leu Leu Glu Asp Tyr Tyr Gln Ser Gly Arg Met Leu Leu Arg Met Ser 
         355                360                365
Gln Ala Leu Gly Arg Ile Val Leu Ala Gly Arg Glu Met Thr Arg Leu 
     370                375                380
Ala Gly Phe Thr Ala Arg Ile Thr Glu Leu Met Gln Val Leu Lys Asp 
 385                390                395                400
Leu Asn His Gly Lys Tyr Glu Arg Thr Met Val Ser Gln Gln Glu Lys 
                 405                410                415
Gly Ile Glu Gly Val Gln Val Ile Pro Leu Ile Pro Gly Ala Gly Glu 
             420                425                430
Ile Ile Ile Ala Asp Asn Ile Ile Lys Phe Asp His Val Pro Leu Ala 
         435                440                445
Thr Pro Asn Gly Asp Val Leu Ile Arg Asp Leu Asn Phe Glu Val Arg 
     450                455                460
Ser Gly Ala Asn Val Leu Ile Cys Gly Pro Asn Gly Cys Gly Lys Ser 
 465                470                475                480
Ser Leu Phe Arg Val Leu Gly Glu Leu Trp Pro Leu Phe Gly Gly Arg 
                 485                490                495
Leu Thr Lys Pro Glu Arg Gly Lys Leu Phe Tyr Val Pro Gln Arg Pro 
             500                505                510
Tyr Met Thr Leu Gly Thr Leu Arg Asp Gln Val Ile Tyr Pro Asp Gly 
         515                520                525
Arg Glu Asp Gln Lys Arg Lys Gly Ile Ser Asp Leu Val Leu Lys Glu 
     530                535                540
Tyr Leu Asp Asn Val Gln Leu Gly His Ile Leu Glu Arg Glu Gly Gly 
 545                550                555                560
Trp Asp Ser Val Gln Asp Trp Met Asp Val Leu Ser Gly Gly Glu Lys 
                 565                570                575
Gln Arg Met Ala Met Ala Arg Leu Phe Tyr His Lys Pro Gln Phe Ala 
             580                585                590
Ile Leu Asp Glu Cys Thr Ser Ala Val Ser Val Asp Val Glu Gly Tyr 
         595                600                605
Ile Tyr Ser His Cys Arg Lys Val Gly Ile Thr Leu Phe Thr Val Ser 
     610                615                620
His Arg Lys Ser Leu Trp Lys His His Glu Tyr Tyr Leu His Met Asp 
 625                630                635                640
Gly Arg Gly Asn Tyr Glu Phe Lys Gln Ile Thr Glu Asp Thr Val Glu 
                 645                650                655
Phe Gly Ser 
             660



<210> 6401
<211> 442
<212> DNA
<213> Rattus norvegicus
<308> AA955167
<400> 6401

cggccgcgt  gccgccggc  gcagctgcg  cctcgtcct  ggcgccgtc  gcggtcgcg  60
cttccgcct  agcgccctc  ccggcctcc  tcttgctct  cttgaagga  aagccgctc  120
gcttgaagg  cttcttgaa  gaaaagcgc  tcttttttt  tttcggggt  tcgctgctg  180
gagacggcg  ggccccgtc  tccgccttg  gggacgacg  ggaggaggc  gacgcgccc  240
cggtctccg  ggaggggga  ccgggctcg  cgggctcgg  ctccgcagc  tccttgtcg  300
ccgtggcag  gcccggctc  ggggccgcg  ctgcctcat  cttatcggc  gcggccggg  360
tcgcggcgc  gccgctcgc  ggctcctcc  tgtcggcgg  cggggcgct  ccgttgggc  420
gcaactcct  cttggcgcc  gg  442



<210> 6402
<211> 308
<212> PRT
<213> Rattus norvegicus
<308> P30009
<400> 6402

Gly Ala Gln Phe Ser Lys Thr Ala Ala Lys Gly Glu Ala Ala Ala Glu 
  1               5                  10                  15
Arg Pro Gly Glu Ala Ala Val Ala Ser Ser Pro Ser Lys Ala Asn Gly 
             20                  25                  30
Gln Glu Asn Gly His Val Lys Val Asn Gly Asp Ala Ser Pro Ala Ala 
         35                  40                  45
Ala Glu Pro Gly Ala Lys Glu Glu Leu Gln Ala Asn Gly Ser Ala Pro 
     50                  55                  60
Ala Ala Asp Lys Glu Glu Pro Ala Ser Gly Gly Ala Ala Thr Pro Ala 
 65                  70                  75                  80
Ala Ala Asp Lys Asp Glu Ala Ala Ala Ala Pro Glu Pro Gly Ala Ala 
                 85                  90                  95
Thr Ala Asp Lys Glu Ala Ala Glu Ala Glu Pro Ala Glu Pro Gly Ser 
             100                105                110
Pro Ser Ala Glu Thr Glu Gly Ala Ser Ala Ser Ser Thr Ser Ser Pro 
         115                120                125
Lys Ala Glu Asp Gly Ala Ala Pro Ser Pro Ser Ser Glu Thr Pro Lys 
     130                135                140
Lys Lys Lys Lys Arg Phe Ser Phe Lys Lys Ser Phe Lys Leu Ser Gly 
 145                150                155                160
Phe Ser Phe Lys Lys Ser Lys Lys Glu Ala Gly Glu Gly Ala Glu Ala 
                 165                170                175
Glu Gly Ala Thr Ala Asp Gly Ala Lys Asp Glu Ala Ala Ala Ala Ala 
             180                185                190
Gly Gly Asp Ala Ala Ala Ala Pro Gly Glu Gln Ala Gly Gly Ala Gly 
         195                200                205
Ala Glu Gly Ala Glu Gly Gly Glu Ser Arg Glu Ala Glu Ala Ala Glu 
     210                215                220
Pro Glu Gln Pro Glu Gln Pro Glu Gln Pro Ala Ala Glu Glu Pro Arg 
 225                230                235                240
Ala Glu Glu Pro Ser Glu Ala Val Gly Glu Lys Ala Glu Glu Pro Ala 
                 245                250                255
Pro Gly Ala Thr Ala Asp Asp Ala Pro Ser Ala Ala Gly Pro Glu Gln 
             260                265                270
Glu Ala Pro Ala Ala Thr Asp Glu Pro Ala Ala Ser Ala Ala Pro Ser 
         275                280                285
Ala Ser Pro Glu Pro Gln Pro Glu Cys Ser Pro Glu Ala Pro Pro Ala 
     290                295                300
Pro Val Ala Glu 
 305



<210> 6403
<211> 865
<212> DNA
<213> Homo sapiens
<308> AU141403
<400> 6403

cccattttt  taaaactgc  gtcatcttg  accttttaa  acacaaatt  taaactcaa  60
caagctgtg  taagtggaa  ggttactgt  tatactgtg  tatgttttt  attacagca  120
ataatgctt  cttttccag  cgtctttga  aataaagga  aaaaaatct  cagatgcaa  180
ggttttgtg  agcatcttg  ctatcatgt  ttgtaaata  tggagaagc  ttgaccaat  240
tgacttaga  atggaatgt  actttgctt  caaaaattg  tattaaact  ctgcttaag  300
tgttctaat  ttctgtgag  acactaaaa  cgaaaaata  atgtgaata  aatgtacaa  360
tttgttgtg  ttttttatg  tctaataat  ctgagactt  taggtctta  gttaatttt  420
aggaagatc  tgcatgcca  caggagtaa  ttttattgt  gttcttaat  tgaagtttt  480
aagctctga  attcataat  cgcagtgtc  gattacgta  aggaagatc  tacaacatt  540
catgtcaaa  ctgttacca  ttattggca  ttagttttc  tttaagaat  gaacataat  600
atttttatt  tagctatat  gcatgtcag  ttaaatcat  tacaacaaa  ggggtgtga  660
cctaagact  tttaaatgt  ttatgagaa  atttcataa  gccattctc  tgncattca  720
gtccagaaa  aaattttaa  ctgagtgag  gtctataga  tcctactgc  gatgggcat  780
aaatgtgac  aaatgtgtt  aaaaattga  ggggattac  tgctattgn  attgcttaa  840
gcttggcta  ttnccaaat  tggct  865



<210> 6404
<211> 411
<212> DNA
<213> Rattus norvegicus
<308> AA955477
<400> 6404

ttttttttt  tttttttaa  gttaaaaat  tgtttatta  tatctgaat  taaaaccca  60
cagcactgt  gtggctgac  agatctaag  tttcccagc  agtgagaaa  gccaggatc  120
aggatcatc  aggaaggag  ctgggtgcc  ggcacttgt  aggtcacca  tcaaccact  180
agcacctgg  tgttaccct  cgcaggata  ggcagagct  gctaagtct  ggctccgcc  240
aggaaaacc  tctctgctc  actcagggc  ctggtcatc  cttccttga  gtcatccca  300
tggtctttg  cttcctcca  cactcgggc  gtatggagt  gggtctgtg  gacctccat  360
gattgattg  tccaaggat  gttcataaa  tgcatgatg  tcagcctct  g  411



<210> 6405
<211> 385
<212> PRT
<213> Rattus norvegicus
<308> CAA54183
<400> 6405

Ile Arg Gly Ser Pro Gly Gln Thr Pro Pro Ala Pro Phe Pro Ser Pro 
  1               5                  10                  15
Pro Pro Pro Ala Pro Ala Gln Pro Pro Pro Pro Phe Pro Gln Phe His 
             20                  25                  30
Val Lys Ser Gly Leu Gln Ile Arg Lys Asn Ala Ile Thr Asp Asp Tyr 
         35                  40                  45
Lys Val Thr Ser Gln Val Leu Gly Leu Gly Ile Asn Gly Lys Val Leu 
     50                  55                  60
Arg Ile Phe Asp Lys Arg Thr Gln Gln Lys Phe Ala Leu Lys Met Leu 
 65                  70                  75                  80
Gln Asp Cys Pro Lys Ala Arg Arg Glu Val Glu Leu Thr Trp Arg Ala 
                 85                  90                  95
Ser Gln Cys Pro His Ile Val His Ile Val Asp Val Tyr Glu Asn Leu 
             100                105                110
Tyr Ala Gly Arg Lys Cys Leu Leu Ile Val Met Glu Cys Leu Asp Gly 
         115                120                125
Gly Glu Leu Phe Ser Arg Ile Gln Asp Arg Gly Asp Gln Ala Phe Thr 
     130                135                140
Glu Arg Glu Ala Ser Glu Ile Met Lys Ser Ile Gly Glu Ala Ile Gln 
 145                150                155                160
Tyr Leu His Ser Ile Asn Ile Ala His Arg Asp Val Lys Pro Glu Asn 
                 165                170                175
Leu Leu Tyr Thr Ser Lys Arg Pro Asn Ala Ile Leu Lys Leu Thr Asp 
             180                185                190
Phe Gly Phe Ala Lys Glu Thr Thr Ser His Asn Ser Leu Thr Thr Pro 
         195                200                205
Cys Tyr Thr Pro Tyr Tyr Val Ala Pro Glu Val Leu Gly Pro Glu Lys 
     210                215                220
Tyr Asp Lys Ser Cys Asp Met Trp Ser Leu Gly Val Ile Met Tyr Ile 
 225                230                235                240
Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Ser Asn His Gly Leu Ala Ile 
                 245                250                255
Ser Pro Gly Met Lys Thr Arg Ile Arg Met Gly Gln Tyr Glu Phe Pro 
             260                265                270
Asn Pro Glu Trp Ser Glu Val Ser Glu Glu Val Lys Met Leu Ile Arg 
         275                280                285
Asn Leu Leu Lys Thr Glu Pro Thr Gln Arg Met Thr Ile Thr Glu Phe 
     290                295                300
Met Asn His Pro Trp Ile Met Gln Ser Thr Lys Val Pro Gln Thr Pro 
 305                310                315                320
Leu His Thr Ser Arg Val Leu Lys Glu Asp Lys Glu Arg Trp Glu Asp 
                 325                330                335
Val Lys Glu Glu Met Thr Ser Ala Leu Ala Thr Met Arg Val Asp Tyr 
             340                345                350
Glu Gln Ile Lys Ile Lys Lys Ile Glu Asp Ala Ser Asn Pro Leu Leu 
         355                360                365
Leu Lys Arg Arg Lys Lys Ala Arg Ala Val Glu Asp Ala Ala Leu Ala 
     370                375                380
His 
 385



<210> 6406
<211> 2481
<212> DNA
<213> Homo sapiens
<308> U09578
<400> 6406

gcccctcgc  ggtacctca  caaggtgcg  tgccgccag  tgccactag  agcgccagg  60
tggggccgc  tctgagcgc  ccgcggggg  catggatgg  gaaacagca  aggagcagg  120
gggccctgt  cccccgcca  ttgcacccg  cggacccgg  ttgggcggt  ctccggggg  180
gcggcggga  cccaagaag  acgcagtga  cgacgacta  cagttgtcc  agcaggtgc  240
gggcctggg  gtgaacggc  aagtgctgg  gtgcttcca  cggcgcact  gacagaagt  300
tgccctgaa  ctcctgtat  acagcccca  ggcccggca  gaggtagac  atcactggc  360
ggcttctgg  ggcccccat  ttgtctgca  cctggatgt  tatgagaac  tgcaccatg  420
caagcgctg  ctcctcatc  tcatggaat  catggaagg  ggtgagttg  tcagcagga  480
tcaggagcg  ggcgaccag  ctttcactg  gagagaagc  gcagagata  tgcgggata  540
tggcactgc  atccagttt  tgcacagcc  taacattgc  caccgagat  tcaagcctg  600
aaacctact  tacacatct  aggagaaag  cgcagtgct  aagctcacc  attttggct  660
tgctaagga  accacccaa  atgccctgc  gacaccctg  tatactccc  attatgtgg  720
ccctgaggt  ctgggtcca  agaagtatg  caagtcatg  gacatgtgg  ccctgggtg  780
catcatgta  atcctcctt  gtggcttcc  acccttcta  tccaacacg  gccaggcca  840
ctccccggg  atgaagagg  ggattcgcc  gggccagta  ggcttcccc  atcctgagt  900
gtcagaagt  tctgaggat  ccaagcagc  gatccgcct  ctgttgaag  cagacccca  960
agagaggct  accatcact  agttcatga  ccacccctg  atcaaccaa  cgatggtag  1020
gccacagac  ccactccac  cggcccgag  gctgcagga  gacaaagac  actgggacg  1080
agtcaagga  gagatgacc  gtgccttgg  cactatgcg  gtagactac  accaggtga  1140
gatcaagga  ctgaagacc  ctaacaacc  gctcctcaa  aagaggaga  aaaagcagg  1200
aggcagctc  tctgcctca  agggctgca  caaccagta  ctcatgggg  cttggagga  1260
cctggcctc  cagcctgca  aacagactg  aatgtgctc  ggccctggc  aggagggcc  1320
agggtcatt  ttttaacaa  ggattattt  gttgtgttt  aatttgtca  tcggaactt  1380
aggatggag  accctgacc  taagcctcc  tcagatctc  ggcccaggc  caagcccta  1440
agatgggca  ggcctaggg  ctgggagct  cctgctgcc  tagcagcac  tttagctag  1500
ttggcccga  tgaggcctc  gtgctgtcc  gccctggtg  atggcctta  ctttctagg  1560
cactgggag  tgtggctgg  cttcccatc  tccacagag  catctccct  tgggatggg  1620
agatgggcc  ggccttgag  aaggcattg  ccattggtt  ccatggtga  cagggacca  1680
gttgctgcc  gtgaatgct  agtgagcga  taagggagg  ggggcgatt  agggttcac  1740
tctgccttg  ggaggctga  ttctcacac  ctggctggc  ctctcattc  cactcctcc  1800
tgggccctg  ggctgctgg  tccagtctg  ctgcctccc  gtgcagtcc  gccctgcct  1860
gctgcagcc  cagcccaga  ggcactcag  gctctcccc  gagggagtc  ctgggccta  1920
ccatcccct  actattccc  acccaaagg  tgacttttc  tctgaactt  aagtgggag  1980
tatttttaa  ttttttcca  tttggaaaa  gtcactgtg  caaaagcca  catactttc  2040
ctgcaccca  ctgctcacc  gatctcagg  aggaaagcc  ctctctgtt  aagtcaggg  2100
ctatctttt  gtatacttg  gtgaaagtg  ctggttggg  gcagagcta  gtggcttcc  2160
attaacctg  ggtctcttt  tttactctg  gtcagacct  aggttgggg  aggcgactg  2220
gccatgctc  gaatgtctg  tcctggctt  ggcctgagt  gggcagaga  ggcctttca  2280
ggctgatca  agcttacca  ccccacccc  ccatggtag  cttagggtg  tgagtgcct  2340
atactgcct  acaagtgcc  gacacgcag  ctagttcct  cctggcccc  ctctcactg  2400
ctgggaaac  ctagaccat  tcagatagg  caacactgc  gggttttac  tccagatag  2460
aataaacac  atttcatca  t  2481



<210> 6407
<211> 382
<212> PRT
<213> Homo sapiens
<308> AAH10407
<400> 6407

Met Asp Gly Glu Thr Ala Glu Glu Gln Gly Gly Pro Val Pro Pro Pro 
  1               5                  10                  15
Val Ala Pro Gly Gly Pro Gly Leu Gly Gly Ala Pro Gly Gly Arg Arg 
             20                  25                  30
Glu Pro Lys Lys Tyr Ala Val Thr Asp Asp Tyr Gln Leu Ser Lys Gln 
         35                  40                  45
Val Leu Gly Leu Gly Val Asn Gly Lys Val Leu Glu Cys Phe His Arg 
     50                  55                  60
Arg Thr Gly Gln Lys Cys Ala Leu Lys Leu Leu Tyr Asp Ser Pro Lys 
 65                  70                  75                  80
Ala Arg Gln Glu Val Asp His His Trp Gln Ala Ser Gly Gly Pro His 
                 85                  90                  95
Ile Val Cys Ile Leu Asp Val Tyr Glu Asn Met His His Gly Lys Arg 
             100                105                110
Cys Leu Leu Ile Ile Met Glu Cys Met Glu Gly Gly Glu Leu Phe Ser 
         115                120                125
Arg Ile Gln Glu Arg Gly Asp Gln Ala Phe Thr Glu Arg Glu Ala Ala 
     130                135                140
Glu Ile Met Arg Asp Ile Gly Thr Ala Ile Gln Phe Leu His Ser His 
 145                150                155                160
Asn Ile Ala His Arg Asp Val Lys Pro Glu Asn Leu Leu Tyr Thr Ser 
                 165                170                175
Lys Glu Lys Asp Ala Val Leu Lys Leu Thr Asp Phe Gly Phe Ala Lys 
             180                185                190
Glu Thr Thr Gln Asn Ala Leu Gln Thr Pro Cys Tyr Thr Pro Tyr Tyr 
         195                200                205
Val Ala Pro Glu Val Leu Gly Pro Glu Lys Tyr Asp Lys Ser Cys Asp 
     210                215                220
Met Trp Ser Leu Gly Val Ile Met Tyr Ile Leu Leu Cys Gly Phe Pro 
 225                230                235                240
Pro Phe Tyr Ser Asn Thr Gly Gln Ala Ile Ser Pro Gly Met Lys Arg 
                 245                250                255
Arg Ile Arg Leu Gly Gln Tyr Gly Phe Pro Asn Pro Glu Trp Ser Glu 
             260                265                270
Val Ser Glu Asp Ala Lys Gln Leu Ile Arg Leu Leu Leu Lys Thr Asp 
         275                280                285
Pro Thr Glu Arg Leu Thr Ile Thr Gln Phe Met Asn His Pro Trp Ile 
     290                295                300
Asn Gln Ser Met Val Val Pro Gln Thr Pro Leu His Thr Ala Arg Val 
 305                310                315                320
Leu Gln Glu Asp Lys Asp His Trp Asp Glu Val Lys Glu Glu Met Thr 
                 325                330                335
Ser Ala Leu Ala Thr Met Arg Val Asp Tyr Asp Gln Val Lys Ile Lys 
             340                345                350
Asp Leu Lys Thr Ser Asn Asn Arg Leu Leu Asn Lys Arg Arg Lys Lys 
         355                360                365
Gln Ala Gly Ser Ser Ser Ala Ser Gln Gly Cys Asn Asn Gln 
     370                375                380



<210> 6408
<211> 553
<212> DNA
<213> Rattus norvegicus
<308> AA955808
<400> 6408

ttttttttt  tttttttgg  ttttaagaa  attttatta  aaaatacaa  atttttgaa  60
aaagatcag  acaattatc  taatgtaca  agtcatagc  gtagcagtt  ttaactaaa  120
tttaaaaac  caacaagga  ggcagccct  tagaccaat  tattttata  ccttttaaa  180
catcaaatt  tcatccaac  aaggacagt  gagtttaca  cttggacaa  ggtacatga  240
tcaggcata  gcagtccat  ctgcccact  gacaacttt  ctgctgaaa  ttcttaaat  300
ctaccaaac  aaaacaaaa  gctanctga  acaaatgag  aggatttcc  tgtaattgt  360
aattggctt  ttaaaaaag  aatgcttcc  gtctcccca  aacagcana  aagcaagag  420
tacatgcag  aatgtgagt  ttaagacat  tctcaagtc  tctcaaacg  gtccatgtg  480
ggatangat  agtgacaaa  ctgatagaa  aacactgct  ttgacacca  aacaaacaa  540
aaagttaga  aat  553



<210> 6409
<211> 305
<212> PRT
<213> Rattus norvegicus
<308> Q64620
<400> 6409

Met Ala Pro Leu Asp Leu Asp Lys Tyr Val Glu Ile Ala Arg Gln Cys 
  1               5                  10                  15
Lys Tyr Leu Pro Glu Asn Asp Leu Lys Arg Leu Cys Asp Tyr Val Cys 
             20                  25                  30
Asp Leu Leu Leu Glu Glu Ser Asn Val Gln Pro Val Ser Thr Pro Val 
         35                  40                  45
Thr Val Cys Gly Asp Ile His Gly Gln Phe Tyr Asp Leu Cys Glu Leu 
     50                  55                  60
Phe Arg Thr Gly Gly Gln Val Leu Asp Thr Asn Tyr Ile Phe Met Gly 
 65                  70                  75                  80
Asp Phe Val Asp Arg Gly His Tyr Xaa Xaa Val Thr Phe Thr Tyr Leu 
                 85                  90                  95
Leu Ala Leu Lys Ala Lys Trp Pro Asp Arg Ile Thr Leu Leu Arg Gly 
             100                105                110
Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly Phe Tyr Asp Glu 
         115                120                125
Cys Gln Thr Lys Tyr Gly Asn Ala Asn Ala Trp Arg Tyr Cys Thr Lys 
     130                135                140
Val Phe Asp Met Leu Thr Val Ala Ala Leu Ile Asp Glu Gln Ile Leu 
 145                150                155                160
Cys Val His Gly Gly Leu Ser Pro Asp Ile Lys Thr Leu Asp Gln Ile 
                 165                170                175
Arg Thr Ile Glu Arg Asn Gln Glu Ile Pro His Lys Gly Ala Phe Cys 
             180                185                190
Asp Leu Val Trp Ser Asp Pro Glu Asp Val Asp Thr Trp Ala Ile Ser 
         195                200                205
Pro Arg Gly Ala Gly Trp Leu Phe Gly Ala Lys Val Thr Asn Glu Phe 
     210                215                220
Val His Ile Asn Asn Leu Lys Leu Ile Cys Arg Ala His Gln Leu Val 
 225                230                235                240
His Glu Gly Tyr Lys Phe Met Phe Asp Glu Lys Leu Val Thr Val Trp 
                 245                250                255
Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Ile Ala Ser Ile Met 
             260                265                270
Val Phe Lys Asp Val Asn Thr Arg Glu Pro Lys Leu Asn Arg Ala Val 
         275                280                285
Pro Asp Ser Glu Arg Val Ile Pro Pro Arg Thr Thr Thr Pro Tyr Phe 
     290                295                300
Leu 
 305



<210> 6410
<211> 1563
<212> DNA
<213> Homo sapiens
<308> BC006990
<400> 6410

ctccgccgc  gccgccgcc  ctgctacag  cgccgccgc  gctgttgcc  cggcttgtt  60
ttcttaaaa  ggcgccgct  gacctggac  agtatgtgg  aatagcgcg  ctgtgcaag  120
acctgccag  gaacgacct  aagcggcta  gtgactacg  ttgtgacct  ctcttagaa  180
agtcaaatg  tcagccagt  tcaacacca  taacagtgt  tggagatat  catggacag  240
tttatgacc  ttgtgaact  ttcagaact  gaggtcagg  tcctgacac  aactacata  300
ttatgggtg  ttttgtaga  agaggttac  atagtttgg  gaccttcac  taccttctt  360
cattaaagg  taaatggcc  gatcgtatt  cacttttgc  aggaaatca  gagagtaga  420
agataacac  ggtctatgg  ttttatgat  agtgccaaa  caaatatgg  aatgctaat  480
cctggagat  ctgtaccaa  gtttttgac  tgctcacag  agcagcttt  atagatgag  540
agattttgt  tgtccatgg  ggtttatct  ctgatatca  aacactgga  caaattcga  600
ccatcgaac  gaatcagga  attcctcat  aaggagcat  ttgtgatct  gtttggtca  660
atcctgaag  tgtggatac  tgggctatc  gtccccgag  agcaggttg  ctttttgga  720
caaaggtca  aaatgagtt  gttcatatc  acaacttaa  actcatctg  agagcacat  780
aactagtgc  cgaaggcta  aaatttatg  ttgatgaga  gctggtgac  gtatggtct  840
ctcctaatt  ctgctatcg  tgtggaaat  ttgcttcga  catggtctt  aaagatgta  900
atacaagag  accaaagtt  ttccgggca  ttccagatt  agaacgtgt  attcctccc  960
gaacgacaa  gccatattt  ctttgaggc  ttcgcccat  ctgctgacc  atttttctg  1020
cctcttctt  ccccaattt  cttgtatta  cctctacaa  atacttttt  ttgagcact  1080
tgctgctga  atgctgcct  ttgcctttt  tttttttaa  ttttaaatt  tctaaattt  1140
ttgtttgtt  tggtgtcta  agcaaagtt  ttctatcaa  tttccccca  cccatcccc  1200
ccctggact  atttgagaa  acttgagaa  tgtcttaat  ctcacactg  tgcatgtag  1260
tcttgctta  ttactggtc  gggaaacag  atgtgtttc  tttttttta  aagccaatt  1320
acagattac  cctaaatac  cctcctttt  tatcattca  ccttttgtt  tagtttggt  1380
agttttaag  aatttcagc  gcaaagttg  tattcagtg  gcacgatgg  ctccaaatg  1440
ctcaagtta  gtatacctg  cccagatgt  aacttcatt  tcctttgtt  gatgatatt  1500
taaatggat  taaaataaa  tggtctaaa  gacaaaaaa  aaaaaaaaa  aaaaaaaaa  1560
aaa  1563



<210> 6411
<211> 305
<212> PRT
<213> Homo sapiens
<308> O00743
<400> 6411

Met Ala Pro Leu Asp Leu Asp Lys Tyr Val Glu Ile Ala Arg Leu Cys 
  1               5                  10                  15
Lys Tyr Leu Pro Glu Asn Asp Leu Lys Arg Leu Cys Asp Tyr Val Cys 
             20                  25                  30
Asp Leu Leu Leu Glu Glu Ser Asn Val Gln Pro Val Ser Thr Pro Val 
         35                  40                  45
Thr Val Cys Gly Asp Ile His Gly Gln Phe Tyr Asp Leu Cys Glu Leu 
     50                  55                  60
Phe Arg Thr Gly Gly Gln Val Pro Asp Thr Asn Tyr Ile Phe Met Gly 
 65                  70                  75                  80
Asp Phe Val Asp Arg Gly Tyr Tyr Ser Leu Glu Thr Phe Thr Tyr Leu 
                 85                  90                  95
Leu Ala Leu Lys Ala Lys Trp Pro Asp Arg Ile Thr Leu Leu Arg Gly 
             100                105                110
Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly Phe Tyr Asp Glu 
         115                120                125
Cys Gln Thr Lys Tyr Gly Asn Ala Asn Ala Trp Arg Tyr Cys Thr Lys 
     130                135                140
Val Phe Asp Met Leu Thr Val Ala Ala Leu Ile Asp Glu Gln Ile Leu 
 145                150                155                160
Cys Val His Gly Gly Leu Ser Pro Asp Ile Lys Thr Leu Asp Gln Ile 
                 165                170                175
Arg Thr Ile Glu Arg Asn Gln Glu Ile Pro His Lys Gly Ala Phe Cys 
             180                185                190
Asp Leu Val Trp Ser Asp Pro Glu Asp Val Asp Thr Trp Ala Ile Ser 
         195                200                205
Pro Arg Gly Ala Gly Trp Leu Phe Gly Ala Lys Val Thr Asn Glu Phe 
     210                215                220
Val His Ile Asn Asn Leu Lys Leu Ile Cys Arg Ala His Gln Leu Val 
 225                230                235                240
His Glu Gly Tyr Lys Phe Met Phe Asp Glu Lys Leu Val Thr Val Trp 
                 245                250                255
Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Ile Ala Ser Ile Met 
             260                265                270
Val Phe Lys Asp Val Asn Thr Arg Glu Pro Lys Leu Phe Arg Ala Val 
         275                280                285
Pro Asp Ser Glu Arg Val Ile Pro Pro Arg Thr Thr Thr Pro Tyr Phe 
     290                295                300
Leu 
 305



<210> 6412
<211> 553
<212> DNA
<213> Rattus norvegicus
<308> AA955808
<400> 6412

ttttttttt  tttttttgg  ttttaagaa  attttatta  aaaatacaa  atttttgaa  60
aaagatcag  acaattatc  taatgtaca  agtcatagc  gtagcagtt  ttaactaaa  120
tttaaaaac  caacaagga  ggcagccct  tagaccaat  tattttata  ccttttaaa  180
catcaaatt  tcatccaac  aaggacagt  gagtttaca  cttggacaa  ggtacatga  240
tcaggcata  gcagtccat  ctgcccact  gacaacttt  ctgctgaaa  ttcttaaat  300
ctaccaaac  aaaacaaaa  gctanctga  acaaatgag  aggatttcc  tgtaattgt  360
aattggctt  ttaaaaaag  aatgcttcc  gtctcccca  aacagcana  aagcaagag  420
tacatgcag  aatgtgagt  ttaagacat  tctcaagtc  tctcaaacg  gtccatgtg  480
ggatangat  agtgacaaa  ctgatagaa  aacactgct  ttgacacca  aacaaacaa  540
aaagttaga  aat  553



<210> 6413
<211> 305
<212> PRT
<213> Rattus norvegicus
<308> Q64620
<400> 6413

Met Ala Pro Leu Asp Leu Asp Lys Tyr Val Glu Ile Ala Arg Gln Cys 
  1               5                  10                  15
Lys Tyr Leu Pro Glu Asn Asp Leu Lys Arg Leu Cys Asp Tyr Val Cys 
             20                  25                  30
Asp Leu Leu Leu Glu Glu Ser Asn Val Gln Pro Val Ser Thr Pro Val 
         35                  40                  45
Thr Val Cys Gly Asp Ile His Gly Gln Phe Tyr Asp Leu Cys Glu Leu 
     50                  55                  60
Phe Arg Thr Gly Gly Gln Val Leu Asp Thr Asn Tyr Ile Phe Met Gly 
 65                  70                  75                  80
Asp Phe Val Asp Arg Gly His Tyr Xaa Xaa Val Thr Phe Thr Tyr Leu 
                 85                  90                  95
Leu Ala Leu Lys Ala Lys Trp Pro Asp Arg Ile Thr Leu Leu Arg Gly 
             100                105                110
Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly Phe Tyr Asp Glu 
         115                120                125
Cys Gln Thr Lys Tyr Gly Asn Ala Asn Ala Trp Arg Tyr Cys Thr Lys 
     130                135                140
Val Phe Asp Met Leu Thr Val Ala Ala Leu Ile Asp Glu Gln Ile Leu 
 145                150                155                160
Cys Val His Gly Gly Leu Ser Pro Asp Ile Lys Thr Leu Asp Gln Ile 
                 165                170                175
Arg Thr Ile Glu Arg Asn Gln Glu Ile Pro His Lys Gly Ala Phe Cys 
             180                185                190
Asp Leu Val Trp Ser Asp Pro Glu Asp Val Asp Thr Trp Ala Ile Ser 
         195                200                205
Pro Arg Gly Ala Gly Trp Leu Phe Gly Ala Lys Val Thr Asn Glu Phe 
     210                215                220
Val His Ile Asn Asn Leu Lys Leu Ile Cys Arg Ala His Gln Leu Val 
 225                230                235                240
His Glu Gly Tyr Lys Phe Met Phe Asp Glu Lys Leu Val Thr Val Trp 
                 245                250                255
Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Ile Ala Ser Ile Met 
             260                265                270
Val Phe Lys Asp Val Asn Thr Arg Glu Pro Lys Leu Asn Arg Ala Val 
         275                280                285
Pro Asp Ser Glu Arg Val Ile Pro Pro Arg Thr Thr Thr Pro Tyr Phe 
     290                295                300
Leu 
 305



<210> 6414
<211> 1563
<212> DNA
<213> Homo sapiens
<308> BC006990
<400> 6414

ctccgccgc  gccgccgcc  ctgctacag  cgccgccgc  gctgttgcc  cggcttgtt  60
ttcttaaaa  ggcgccgct  gacctggac  agtatgtgg  aatagcgcg  ctgtgcaag  120
acctgccag  gaacgacct  aagcggcta  gtgactacg  ttgtgacct  ctcttagaa  180
agtcaaatg  tcagccagt  tcaacacca  taacagtgt  tggagatat  catggacag  240
tttatgacc  ttgtgaact  ttcagaact  gaggtcagg  tcctgacac  aactacata  300
ttatgggtg  ttttgtaga  agaggttac  atagtttgg  gaccttcac  taccttctt  360
cattaaagg  taaatggcc  gatcgtatt  cacttttgc  aggaaatca  gagagtaga  420
agataacac  ggtctatgg  ttttatgat  agtgccaaa  caaatatgg  aatgctaat  480
cctggagat  ctgtaccaa  gtttttgac  tgctcacag  agcagcttt  atagatgag  540
agattttgt  tgtccatgg  ggtttatct  ctgatatca  aacactgga  caaattcga  600
ccatcgaac  gaatcagga  attcctcat  aaggagcat  ttgtgatct  gtttggtca  660
atcctgaag  tgtggatac  tgggctatc  gtccccgag  agcaggttg  ctttttgga  720
caaaggtca  aaatgagtt  gttcatatc  acaacttaa  actcatctg  agagcacat  780
aactagtgc  cgaaggcta  aaatttatg  ttgatgaga  gctggtgac  gtatggtct  840
ctcctaatt  ctgctatcg  tgtggaaat  ttgcttcga  catggtctt  aaagatgta  900
atacaagag  accaaagtt  ttccgggca  ttccagatt  agaacgtgt  attcctccc  960
gaacgacaa  gccatattt  ctttgaggc  ttcgcccat  ctgctgacc  atttttctg  1020
cctcttctt  ccccaattt  cttgtatta  cctctacaa  atacttttt  ttgagcact  1080
tgctgctga  atgctgcct  ttgcctttt  tttttttaa  ttttaaatt  tctaaattt  1140
ttgtttgtt  tggtgtcta  agcaaagtt  ttctatcaa  tttccccca  cccatcccc  1200
ccctggact  atttgagaa  acttgagaa  tgtcttaat  ctcacactg  tgcatgtag  1260
tcttgctta  ttactggtc  gggaaacag  atgtgtttc  tttttttta  aagccaatt  1320
acagattac  cctaaatac  cctcctttt  tatcattca  ccttttgtt  tagtttggt  1380
agttttaag  aatttcagc  gcaaagttg  tattcagtg  gcacgatgg  ctccaaatg  1440
ctcaagtta  gtatacctg  cccagatgt  aacttcatt  tcctttgtt  gatgatatt  1500
taaatggat  taaaataaa  tggtctaaa  gacaaaaaa  aaaaaaaaa  aaaaaaaaa  1560
aaa  1563



<210> 6415
<211> 305
<212> PRT
<213> Homo sapiens
<308> O00743
<400> 6415

Met Ala Pro Leu Asp Leu Asp Lys Tyr Val Glu Ile Ala Arg Leu Cys 
  1               5                  10                  15
Lys Tyr Leu Pro Glu Asn Asp Leu Lys Arg Leu Cys Asp Tyr Val Cys 
             20                  25                  30
Asp Leu Leu Leu Glu Glu Ser Asn Val Gln Pro Val Ser Thr Pro Val 
         35                  40                  45
Thr Val Cys Gly Asp Ile His Gly Gln Phe Tyr Asp Leu Cys Glu Leu 
     50                  55                  60
Phe Arg Thr Gly Gly Gln Val Pro Asp Thr Asn Tyr Ile Phe Met Gly 
 65                  70                  75                  80
Asp Phe Val Asp Arg Gly Tyr Tyr Ser Leu Glu Thr Phe Thr Tyr Leu 
                 85                  90                  95
Leu Ala Leu Lys Ala Lys Trp Pro Asp Arg Ile Thr Leu Leu Arg Gly 
             100                105                110
Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly Phe Tyr Asp Glu 
         115                120                125
Cys Gln Thr Lys Tyr Gly Asn Ala Asn Ala Trp Arg Tyr Cys Thr Lys 
     130                135                140
Val Phe Asp Met Leu Thr Val Ala Ala Leu Ile Asp Glu Gln Ile Leu 
 145                150                155                160
Cys Val His Gly Gly Leu Ser Pro Asp Ile Lys Thr Leu Asp Gln Ile 
                 165                170                175
Arg Thr Ile Glu Arg Asn Gln Glu Ile Pro His Lys Gly Ala Phe Cys 
             180                185                190
Asp Leu Val Trp Ser Asp Pro Glu Asp Val Asp Thr Trp Ala Ile Ser 
         195                200                205
Pro Arg Gly Ala Gly Trp Leu Phe Gly Ala Lys Val Thr Asn Glu Phe 
     210                215                220
Val His Ile Asn Asn Leu Lys Leu Ile Cys Arg Ala His Gln Leu Val 
 225                230                235                240
His Glu Gly Tyr Lys Phe Met Phe Asp Glu Lys Leu Val Thr Val Trp 
                 245                250                255
Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Ile Ala Ser Ile Met 
             260                265                270
Val Phe Lys Asp Val Asn Thr Arg Glu Pro Lys Leu Phe Arg Ala Val 
         275                280                285
Pro Asp Ser Glu Arg Val Ile Pro Pro Arg Thr Thr Thr Pro Tyr Phe 
     290                295                300
Leu 
 305



<210> 6416
<211> 386
<212> DNA
<213> Rattus norvegicus
<308> AA957003
<400> 6416

ttttttttt  tttttttaa  atatgacga  tttattctg  aaacatatc  aagggccca  60
ccccaggcc  aaagctctg  taccccttg  ggctgtctt  atgaactgc  aagcccacc  120
ttatcacca  cacaaggaa  tcttcgaag  taattgcgt  gtcactatt  acgtccaat  180
ctttgaaca  gctttcggt  tttttattc  gcacaaact  agggcactc  gtagtgacc  240
ttttcctga  gtcatccct  taaagggca  ggtgattcc  ttttatacc  aaataattg  300
ggtaaactt  aatgacgtt  ctcaaggcc  tctccaatt  aattgccat  gtcgataaa  360
atttccttt  acacaaggt  tggacc  386



<210> 6417
<211> 88
<212> PRT
<213> Rattus norvegicus
<308> P50115
<400> 6417

Ala Thr Glu Leu Glu Lys Ala Leu Ser Asn Val Ile Glu Val Tyr His 
  1               5                  10                  15
Asn Tyr Ser Gly Ile Lys Gly Asn His His Ala Leu Tyr Arg Asp Asp 
             20                  25                  30
Phe Arg Lys Met Val Thr Thr Glu Cys Pro Gln Phe Val Gln Asn Lys 
         35                  40                  45
Asn Thr Glu Ser Leu Phe Lys Glu Leu Asp Val Asn Ser Asp Asn Ala 
     50                  55                  60
Ile Asn Phe Glu Glu Phe Leu Val Leu Val Ile Arg Val Gly Val Ala 
 65                  70                  75                  80
Ala His Lys Asp Ser His Lys Glu 
                 85



<210> 6418
<211> 418
<212> DNA
<213> Homo sapiens
<308> X06234
<400> 6418

atgtctctt  tcagctgtc  ttcagaaga  ctggtgggg  aagttccgt  ggcatcatg  60
tgaccgagc  ggagaaagc  ttgaactct  tcatcgacg  ctaccacaa  tactccctg  120
taaagggga  tttccatgc  gtctacagg  atgacctga  gaaattgct  gagaccgag  180
gtcctcagt  tatcaggaa  aagggtgca  acgtctggt  caaagagtt  gatatcaac  240
ctgatggtg  agttaactt  caggagttc  tcattctgg  gataaagat  ggcgtggca  300
cccacaaaa  aagccatga  gaaagccac  aagagtagc  gagttactg  gcccagagg  360
tgggcccct  gacatgtac  tgcagaata  taaagtcat  aatacctca  aaaaaaaa  418



<210> 6419
<211> 93
<212> PRT
<213> Homo sapiens
<308> P05109
<400> 6419

Met Leu Thr Glu Leu Glu Lys Ala Leu Asn Ser Ile Ile Asp Val Tyr 
  1               5                  10                  15
His Lys Tyr Ser Leu Ile Lys Gly Asn Phe His Ala Val Tyr Arg Asp 
             20                  25                  30
Asp Leu Lys Lys Leu Leu Glu Thr Glu Cys Pro Gln Tyr Ile Arg Lys 
         35                  40                  45
Lys Gly Ala Asp Val Trp Phe Lys Glu Leu Asp Ile Asn Thr Asp Gly 
     50                  55                  60
Ala Val Asn Phe Gln Glu Phe Leu Ile Leu Val Ile Lys Met Gly Val 
 65                  70                  75                  80
Ala Ala His Lys Lys Ser His Glu Glu Ser His Lys Glu 
                 85                  90



<210> 6420
<211> 377
<212> DNA
<213> Rattus norvegicus
<308> AA957640
<400> 6420

ttttttttt  tttttttac  gaatagctg  tcaagaggt  cattgacga  agtccatgg  60
aagcacaga  aagaggcaa  cacctaaaa  acccaaccc  tacatagca  aggttaagc  120
ataacttag  actcctcgt  ggataggcc  ggggtgggg  aggcgtcat  cactcctgt  180
cttgggctc  cggtagcgc  actggatgt  atcgaaaat  tcctgctcg  tgtccaccg  240
aaggggctc  ccagcaacc  cagtgaccc  cagggggcg  atggtgtac  cattgattg  300
gaagccctt  tccagggca  gcgctctca  attcttatt  aagatgtca  ttccagtga  360
gtagagaac  ccacagt  377



<210> 6421
<211> 334
<212> PRT
<213> Rattus norvegicus
<308> P06766
<400> 6421

Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr Asp 
  1               5                  10                  15
Met Leu Val Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala Ile 
             20                  25                  30
His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys Tyr 
         35                  40                  45
Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly Val 
     50                  55                  60
Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly Lys 
 65                  70                  75                  80
Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser Ile 
                 85                  90                  95
Asn Phe Leu Thr Arg Val Thr Gly Ile Gly Pro Ser Ala Ala Arg Lys 
             100                105                110
Leu Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn Glu 
         115                120                125
Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys Tyr Phe Glu Asp 
     130                135                140
Phe Glu Lys Arg Ile Pro Arg Glu Glu Met Leu Gln Met Gln Asp Ile 
 145                150                155                160
Val Leu Asn Glu Val Lys Lys Leu Asp Pro Glu Tyr Ile Ala Thr Val 
                 165                170                175
Cys Gly Ser Phe Arg Arg Gly Ala Glu Ser Ser Gly Asp Met Asp Val 
             180                185                190
Leu Leu Thr His Pro Asn Phe Thr Ser Glu Ser Ser Lys Gln Pro Lys 
         195                200                205
Leu Leu His Arg Val Val Glu Gln Leu Gln Lys Val Arg Phe Ile Thr 
     210                215                220
Asp Thr Leu Ser Lys Gly Glu Thr Lys Phe Met Gly Val Cys Gln Leu 
 225                230                235                240
Pro Ser Glu Asn Asp Glu Asn Glu Tyr Pro His Arg Arg Ile Asp Ile 
                 245                250                255
Arg Leu Ile Pro Lys Asp Gln Tyr Tyr Cys Gly Val Leu Tyr Phe Thr 
             260                265                270
Gly Ser Asp Ile Phe Asn Lys Asn Met Arg Ala His Ala Leu Glu Lys 
         275                280                285
Gly Phe Thr Ile Asn Glu Tyr Thr Ile Arg Pro Leu Gly Val Thr Gly 
     290                295                300
Val Ala Gly Glu Pro Leu Pro Val Asp Ser Glu Gln Asp Ile Phe Asp 
 305                310                315                320
Tyr Ile Gln Trp Arg Tyr Arg Glu Pro Lys Asp Arg Ser Glu 
                 325                330



<210> 6422
<211> 1259
<212> DNA
<213> Homo sapiens
<308> M13140
<400> 6422

ccggagctg  gttgctcct  ctcccgtct  caagtcctg  tacctcctt  aagctggga  60
agggctcta  tccctggtt  tgaacactc  ggggttctc  ggtgcaggc  gccatgagc  120
aacggaagg  gccgcagga  actctcaac  ggggaatca  cgacatgct  acagaactc  180
caaactttg  gaagaacgt  agccaagct  tccacaagt  caatgctta  agaaaagca  240
catctgtta  agcaaaata  ccacacaaa  taaagagtg  agctgaagc  aagaaattg  300
ctggagtag  aacaaaaat  gctgaaaag  ttgatgagt  tttagcaac  ggaaaatta  360
gtaaactgg  aaagattcg  caggatgat  cgagttcat  catcaattt  ctgactcga  420
ttagtggca  tggtccatc  gctgcaagg  agtttgtag  tgaaggaat  aaaacacta  480
aagatctca  aaaaaatga  gataaattg  accatcatc  gcgaattgg  ctgaaatat  540
ttggggact  tgaaaaaag  attcctcgt  aagagatgt  acaaatgca  gatattgtt  600
taaatgaag  taaaaaagt  gattctgaa  acattgcta  agtctgtgg  agtttcaga  660
gaggtgcag  gtccagtgg  gacatggat  ttctcctga  ccatcccag  ttcacttca  720
aatcaacca  acagccaaa  ctgttacat  aggttgtgg  gcagttaca  aaggttcat  780
ttatcacag  tacccgttc  aagggtgag  caaagttca  gggtgtttg  cagcttccc  840
gtaaaaatg  tgaaaaaga  tatccacac  gaagaattg  tatcaggtt  tacccaaaa  900
atcagtatt  ctgtggtgt  ctctatttc  ctgggagtg  tattttcaa  aagaatatg  960
gagctcatg  caaggaaaa  ggtttcaca  tcaatgagt  caccatccg  cccttggga  1020
tcactggag  tgcaggaga  cccctgcca  tggatagtg  aaaagacat  tttgattac  1080
tccagtgga  ataccggga  cccaaggac  ggagcgaat  aggcctgta  cctccctgg  1140
gcagacaca  cccaatggg  cttaattta  ttcttaacc  ttgctatgt  agggtcttt  1200
gtgttttta  atgattgtt  cttcttcat  cttttgctt  caatgtagt  aataaaacc  1259



<210> 6423
<211> 334
<212> PRT
<213> Homo sapiens
<308> P06746
<400> 6423

Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr Asp 
  1               5                  10                  15
Met Leu Thr Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala Ile 
             20                  25                  30
His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys Tyr 
         35                  40                  45
Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly Val 
     50                  55                  60
Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly Lys 
 65                  70                  75                  80
Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser Ile 
                 85                  90                  95
Asn Phe Leu Thr Arg Val Ser Gly Ile Gly Pro Ser Ala Ala Arg Lys 
             100                105                110
Phe Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn Glu 
         115                120                125
Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys Tyr Phe Gly Asp 
     130                135                140
Phe Glu Lys Arg Ile Pro Arg Glu Glu Met Leu Gln Met Gln Asp Ile 
 145                150                155                160
Val Leu Asn Glu Val Lys Lys Val Asp Ser Glu Tyr Ile Ala Thr Val 
                 165                170                175
Cys Gly Ser Phe Arg Arg Gly Ala Glu Ser Ser Gly Asp Met Asp Val 
             180                185                190
Leu Leu Thr His Pro Ser Phe Thr Ser Glu Ser Thr Lys Gln Pro Lys 
         195                200                205
Leu Leu His Gln Val Val Glu Gln Leu Gln Lys Val His Phe Ile Thr 
     210                215                220
Asp Thr Leu Ser Lys Gly Glu Thr Lys Phe Met Gly Val Cys Gln Leu 
 225                230                235                240
Pro Ser Lys Asn Asp Glu Lys Glu Tyr Pro His Arg Arg Ile Asp Ile 
                 245                250                255
Arg Leu Ile Pro Lys Asp Gln Tyr Tyr Cys Gly Val Leu Tyr Phe Thr 
             260                265                270
Gly Ser Asp Ile Phe Asn Lys Asn Met Arg Ala His Ala Leu Glu Lys 
         275                280                285
Gly Phe Thr Ile Asn Glu Tyr Thr Ile Arg Pro Leu Gly Val Thr Gly 
     290                295                300
Val Ala Gly Glu Pro Leu Pro Val Asp Ser Glu Lys Asp Ile Phe Asp 
 305                310                315                320
Tyr Ile Gln Trp Lys Tyr Arg Glu Pro Lys Asp Arg Ser Glu 
                 325                330



<210> 6424
<211> 419
<212> DNA
<213> Rattus norvegicus
<308> AA957917
<400> 6424

ttttttttt  tttttttgc  ttaaaattt  catcctaac  acattggac  ggtgcacat  60
tcacctgta  cactgtgtc  ataaaagca  tccacacac  aaaatgagc  gaaggaatg  120
accgttcac  ctcccccca  gagcctcac  tacaatctt  tcacgagga  gccaaacag  180
caggacggt  tgaactcca  aaaataacc  cacataaca  acattcacc  ctgactttg  240
cttctgtag  agttccatg  ctcatgtat  ctctgttgg  cactcactt  gctacctca  300
ccatacctg  actcaagta  cctggcact  agatcccca  taagattct  tagtgtttg  360
gtaccaaga  aacagtaag  ttttattag  atgaaataa  tttctgcct  gtgccgaat  419



<210> 6425
<211> 624
<212> PRT
<213> Rattus norvegicus
<308> P30823
<400> 6425

Met Gly Cys Lys Asn Leu Leu Ser Leu Gly Gln Gln Met Leu Arg Arg 
  1               5                  10                  15
Lys Val Val Asp Cys Ser Arg Glu Glu Ser Arg Leu Ser Arg Cys Leu 
             20                  25                  30
Asn Thr Tyr Asp Leu Val Ala Leu Gly Val Gly Ser Thr Leu Gly Ala 
         35                  40                  45
Gly Val Tyr Val Leu Ala Gly Ala Val Ala Arg Glu Asn Ala Gly Pro 
     50                  55                  60
Ala Ile Val Ile Ser Phe Leu Ile Ala Ala Leu Ala Ser Val Leu Ala 
 65                  70                  75                  80
Gly Leu Cys Tyr Gly Glu Phe Gly Ala Arg Val Pro Lys Thr Gly Ser 
                 85                  90                  95
Ala Tyr Leu Tyr Ser Tyr Val Thr Val Gly Glu Leu Trp Ala Phe Ile 
             100                105                110
Thr Gly Trp Asn Leu Ile Leu Ser Tyr Ile Ile Gly Thr Ser Ser Val 
         115                120                125
Ala Arg Ala Trp Ser Ala Thr Phe Asp Glu Leu Ile Gly Lys Pro Ile 
     130                135                140
Gly Glu Phe Ser Arg Gln His Met Ala Leu Asn Ala Pro Gly Val Leu 
 145                150                155                160
Ala Gln Thr Pro Asp Ile Phe Ala Val Ile Ile Ile Ile Ile Leu Thr 
                 165                170                175
Gly Leu Leu Thr Leu Gly Val Lys Glu Ser Ala Met Val Asn Lys Ile 
             180                185                190
Phe Thr Cys Ile Asn Val Leu Val Leu Cys Phe Ile Met Val Ser Gly 
         195                200                205
Phe Val Lys Gly Ser Ile Glu Asn Trp Gln Leu Thr Glu Asn Lys Ser 
     210                215                220
Ser Pro Leu Cys Gly Asn Asn Asp Thr Asn Val Lys Tyr Gly Glu Gly 
 225                230                235                240
Gly Phe Met Pro Phe Gly Phe Ser Gly Val Leu Ser Gly Ala Ala Thr 
                 245                250                255
Cys Phe Tyr Ala Phe Val Gly Phe Asp Cys Ile Ala Thr Thr Gly Glu 
             260                265                270
Glu Val Lys Asn Pro Gln Lys Ala Ile Pro Val Gly Ile Val Ala Ser 
         275                280                285
Leu Leu Ile Cys Phe Ile Ala Tyr Phe Gly Val Ser Ala Ala Leu Thr 
     290                295                300
Leu Met Met Pro Tyr Phe Cys Leu Asp Thr Asp Ser Pro Leu Pro Gly 
 305                310                315                320
Ala Phe Lys Tyr Arg Gly Trp Glu Glu Ala Lys Tyr Ala Val Ala Val 
                 325                330                335
Gly Ser Leu Cys Ala Leu Ser Thr Ser Pro Leu Gly Ser Met Phe Pro 
             340                345                350
Met Pro Arg Val Ile Tyr Ala Met Ala Glu Asp Gly Leu Leu Phe Lys 
         355                360                365
Phe Leu Ala Lys Ile Asn Asp Arg Thr Lys Thr Pro Ile Ile Ala Thr 
     370                375                380
Val Thr Ser Gly Ala Ile Ala Ala Val Met Ala Phe Leu Phe Glu Leu 
 385                390                395                400
Lys Asp Leu Val Asp Leu Met Ser Ile Gly Thr Leu Leu Ala Tyr Ser 
                 405                410                415
Leu Val Ala Ala Cys Val Leu Val Leu Arg Tyr Gln Pro Glu Gln Pro 
             420                425                430
Asn Leu Val Tyr Gln Met Ala Arg Thr Thr Asp Glu Leu Asp Gln Val 
         435                440                445
Asp Gln Asn Glu Met Val Ser Ala Ser Glu Ser Gln Thr Gly Phe Leu 
     450                455                460
Pro Ala Ala Glu Lys Phe Ser Leu Lys Thr Ile Leu Ser Pro Lys Asn 
 465                470                475                480
Met Glu Pro Ser Lys Phe Ser Gly Leu Ile Val Asn Ile Ser Ala Gly 
                 485                490                495
Leu Leu Ala Val Leu Ile Ile Thr Val Cys Ile Val Ala Val Leu Gly 
             500                505                510
Arg Glu Ala Leu Ala Glu Gly Thr Leu Trp Ala Val Phe Val Met Thr 
         515                520                525
Gly Ser Val Leu Leu Cys Met Leu Val Thr Gly Ile Ile Trp Arg Gln 
     530                535                540
Pro Glu Ser Lys Thr Lys Leu Ser Phe Lys Val Pro Phe Val Pro Val 
 545                550                555                560
Leu Pro Val Leu Ser Ile Phe Val Asn Ile Tyr Leu Met Met Gln Leu 
                 565                570                575
Asp Gln Gly Thr Trp Val Arg Phe Ala Val Trp Met Leu Ile Ala Phe 
             580                585                590
Ala Ile Tyr Phe Gly Tyr Gly Val Trp His Ser Glu Glu Ala Ser Leu 
         595                600                605
Ala Ala Gly Gln Ala Lys Thr Pro Asp Ser Asn Leu Asp Gln Cys Lys 
     610                615                620



<210> 6426
<211> 2157
<212> DNA
<213> Homo sapiens
<308> X59155
<400> 6426

cgatcctgc  ggagccccg  cgccgccgg  ttggattct  aaaccttcc  tgtatccct  60
ctgagacat  tttgctgca  gatcgaggc  gtcctctgg  gagaaggtg  tgaggcttc  120
cgtcatatt  cagctctga  cagcaacat  gggtgcaaa  tcctgctca  cattgggca  180
cagatgctg  ggcggaagg  ggtggactg  agccgggag  agacgcggc  gtctcgctg  240
ctgaacact  ttgatctgg  ggccctcgg  gtgggcagc  cactgggtg  tggtgtcta  300
gtcctggct  gagctgtgg  ccgtgagaa  gcaggccct  ccattgtca  ctccttcct  360
atcgctgcg  tggcctcag  gctggctgg  ctgtgctat  gcgagtttg  tgctcgggt  420
cccaagacg  gctcagctt  cctctacag  tatgtcacc  ttggagagc  ctgggcctt  480
atcaccggc  ggaacttaa  cctctccta  atcatcggt  cttcaagcg  agcgagggc  540
tggagcgcc  ccttcgacg  gctgatagg  agacccatc  gggagttct  acggacaca  600
atgactctg  acgcccccg  cgtgctggc  gaaaacccc  acatattcg  agtgatcat  660
attctcatc  tgacaggac  tttaactct  ggtgtgaaa  agtcggcca  ggtcaacaa  720
atattcact  gtattaacg  cctggtcct  ggcttcata  tggtgtcag  atttgtgaa  780
ggatcggtt  aaaactggc  gctcacgga  gaggatttt  ggaacacat  aggccgtct  840
tgtttgaac  atgacacaa  agaagggaa  cccggtgtt  gtggattca  gcccttcgg  900
ttctctggt  tcctgtcgg  ggcagcgac  tgcttctat  ccttcgtgg  ctttgactg  960
atcgccacc  caggtgaag  ggtgaagaa  ccacagaag  ccatccccg  ggggatcgt  1020
gcgtccctc  tgatctgct  catcgccta  tttggggtg  cggctgccc  cacgctcat  1080
atgccctac  tctgcctgg  caataacag  cccctgccc  acgccttta  gcacgtggg  1140
tgggaaggt  ccaagtacg  agtggccgt  ggctccctc  gcgctcttt  cgccagtct  1200
ctaggttcc  tgtttccca  gcctcgggt  atctatgcc  tggctgagg  tggactgct  1260
tttaaattc  tagccaacg  caatgatag  accaaaaca  caataatcg  cacattagc  1320
tcgggtgcc  ttgctgctg  gatggcctt  ctctttgac  tgaaggact  ggtggacct  1380
atgtccatt  gcactctcc  ggcttactc  ttggtggct  cctgtgtgt  ggtcttacg  1440
taccagcca  agcagccta  cctggtata  cagatggcc  gtacttccg  cgagttaga  1500
ccagcagac  aaaatgaat  ggcaagcac  aatgattcc  agctggggt  tttaccaga  1560
gcagagatg  tctctttga  aaccatact  tcacccaaa  acatggagc  ttccaaaat  1620
tctgggcta  ttgtgaaca  ttcaaccag  cttatagct  ttctcatca  caccttctg  1680
attgtgacc  tgcttggaa  ggaggctct  accaaaggg  cgctgtggg  agtctttct  1740
ctcgcaggg  ctgccctcc  ctgtgccgt  gtcacgggc  tcatctgga  gcagcccga  1800
agcaagacc  agctctcat  taaggttcc  ttcctgcca  tgctcccca  cctgagcat  1860
ttcgtgaac  tctatctca  gatgcagct  gaccagggc  cctgggtcc  gtttgctgt  1920
tggatgctg  taggcttca  catctactt  ggctatggc  tgtggcaca  cgaggaggc  1980
tccctggat  ccgaccaag  aaggactcc  gacggcaac  tggaccagt  caagtgacg  2040
acagccccg  cccccggag  tggcagcag  cccgaggga  gcccccaga  gaccgggag  2100
caccccacc  tccccacca  tgcaacaga  accacctgc  tccacaccc  cactgca  2157



<210> 6427
<211> 629
<212> PRT
<213> Homo sapiens
<308> P30825
<400> 6427

Met Gly Cys Lys Val Leu Leu Asn Ile Gly Gln Gln Met Leu Arg Arg 
  1               5                  10                  15
Lys Val Val Asp Cys Ser Arg Glu Glu Thr Arg Leu Ser Arg Cys Leu 
             20                  25                  30
Asn Thr Phe Asp Leu Val Ala Leu Gly Val Gly Ser Thr Leu Gly Ala 
         35                  40                  45
Gly Val Tyr Val Leu Ala Gly Ala Val Ala Arg Glu Asn Ala Gly Pro 
     50                  55                  60
Ala Ile Val Ile Ser Phe Leu Ile Ala Ala Leu Ala Ser Val Leu Ala 
 65                  70                  75                  80
Gly Leu Cys Tyr Gly Glu Phe Gly Ala Arg Val Pro Lys Thr Gly Ser 
                 85                  90                  95
Ala Tyr Leu Tyr Ser Tyr Val Thr Val Gly Glu Leu Trp Ala Phe Ile 
             100                105                110
Thr Gly Trp Asn Leu Ile Leu Ser Tyr Ile Ile Gly Thr Ser Ser Val 
         115                120                125
Ala Arg Ala Trp Ser Ala Thr Phe Asp Glu Leu Ile Gly Arg Pro Ile 
     130                135                140
Gly Glu Phe Ser Arg Thr His Met Thr Leu Asn Ala Pro Gly Val Leu 
 145                150                155                160
Ala Glu Asn Pro Asp Ile Phe Ala Val Ile Ile Ile Leu Ile Leu Thr 
                 165                170                175
Gly Leu Leu Thr Leu Gly Val Lys Glu Ser Ala Met Val Asn Lys Ile 
             180                185                190
Phe Thr Cys Ile Asn Val Leu Val Leu Gly Phe Ile Met Val Ser Gly 
         195                200                205
Phe Val Lys Gly Ser Val Lys Asn Trp Gln Leu Thr Glu Glu Asp Phe 
     210                215                220
Gly Asn Thr Ser Gly Arg Leu Cys Leu Asn Asn Asp Thr Lys Glu Gly 
 225                230                235                240
Lys Pro Gly Val Gly Gly Phe Met Pro Phe Gly Phe Ser Gly Val Leu 
                 245                250                255
Ser Gly Ala Ala Thr Cys Phe Tyr Ala Phe Val Gly Phe Asp Cys Ile 
             260                265                270
Ala Thr Thr Gly Glu Glu Val Lys Asn Pro Gln Lys Ala Ile Pro Val 
         275                280                285
Gly Ile Val Ala Ser Leu Leu Ile Cys Phe Ile Ala Tyr Phe Gly Val 
     290                295                300
Ser Ala Ala Leu Thr Leu Met Met Pro Tyr Phe Cys Leu Asp Asn Asn 
 305                310                315                320
Ser Pro Leu Pro Asp Ala Phe Lys His Val Gly Trp Glu Gly Ala Lys 
                 325                330                335
Tyr Ala Val Ala Val Gly Ser Leu Cys Ala Leu Ser Ala Ser Leu Leu 
             340                345                350
Gly Ser Met Phe Pro Met Pro Arg Val Ile Tyr Ala Met Ala Glu Asp 
         355                360                365
Gly Leu Leu Phe Lys Phe Leu Ala Asn Val Asn Asp Arg Thr Lys Thr 
     370                375                380
Pro Ile Ile Ala Thr Leu Ala Ser Gly Ala Val Ala Ala Val Met Ala 
 385                390                395                400
Phe Leu Phe Asp Leu Lys Asp Leu Val Asp Leu Met Ser Ile Gly Thr 
                 405                410                415
Leu Leu Ala Tyr Ser Leu Val Ala Ala Cys Val Leu Val Leu Arg Tyr 
             420                425                430
Gln Pro Glu Gln Pro Asn Leu Val Tyr Gln Met Ala Ser Thr Ser Asp 
         435                440                445
Glu Leu Asp Pro Ala Asp Gln Asn Glu Leu Ala Ser Thr Asn Asp Ser 
     450                455                460
Gln Leu Gly Phe Leu Pro Glu Ala Glu Met Phe Ser Leu Lys Thr Ile 
 465                470                475                480
Leu Ser Pro Lys Asn Met Glu Pro Ser Lys Ile Ser Gly Leu Ile Val 
                 485                490                495
Asn Ile Ser Thr Ser Leu Ile Ala Val Leu Ile Ile Thr Phe Cys Ile 
             500                505                510
Val Thr Val Leu Gly Arg Glu Ala Leu Thr Lys Gly Ala Leu Trp Ala 
         515                520                525
Val Phe Leu Leu Ala Gly Ser Ala Leu Leu Cys Ala Val Val Thr Gly 
     530                535                540
Val Ile Trp Arg Gln Pro Glu Ser Lys Thr Lys Leu Ser Phe Lys Val 
 545                550                555                560
Pro Phe Leu Pro Val Leu Pro Ile Leu Ser Ile Phe Val Asn Val Tyr 
                 565                570                575
Leu Met Met Gln Leu Asp Gln Gly Thr Trp Val Arg Phe Ala Val Trp 
             580                585                590
Met Leu Ile Gly Phe Ile Ile Tyr Phe Gly Tyr Gly Leu Trp His Ser 
         595                600                605
Glu Glu Ala Ser Leu Asp Ala Asp Gln Ala Arg Thr Pro Asp Gly Asn 
     610                615                620
Leu Asp Gln Cys Lys 
 625



<210> 6428
<211> 419
<212> DNA
<213> Rattus norvegicus
<308> AA957917
<400> 6428

ttttttttt  tttttttgc  ttaaaattt  catcctaac  acattggac  ggtgcacat  60
tcacctgta  cactgtgtc  ataaaagca  tccacacac  aaaatgagc  gaaggaatg  120
accgttcac  ctcccccca  gagcctcac  tacaatctt  tcacgagga  gccaaacag  180
caggacggt  tgaactcca  aaaataacc  cacataaca  acattcacc  ctgactttg  240
cttctgtag  agttccatg  ctcatgtat  ctctgttgg  cactcactt  gctacctca  300
ccatacctg  actcaagta  cctggcact  agatcccca  taagattct  tagtgtttg  360
gtaccaaga  aacagtaag  ttttattag  atgaaataa  tttctgcct  gtgccgaat  419



<210> 6429
<211> 624
<212> PRT
<213> Rattus norvegicus
<308> P30823
<400> 6429

Met Gly Cys Lys Asn Leu Leu Ser Leu Gly Gln Gln Met Leu Arg Arg 
  1               5                  10                  15
Lys Val Val Asp Cys Ser Arg Glu Glu Ser Arg Leu Ser Arg Cys Leu 
             20                  25                  30
Asn Thr Tyr Asp Leu Val Ala Leu Gly Val Gly Ser Thr Leu Gly Ala 
         35                  40                  45
Gly Val Tyr Val Leu Ala Gly Ala Val Ala Arg Glu Asn Ala Gly Pro 
     50                  55                  60
Ala Ile Val Ile Ser Phe Leu Ile Ala Ala Leu Ala Ser Val Leu Ala 
 65                  70                  75                  80
Gly Leu Cys Tyr Gly Glu Phe Gly Ala Arg Val Pro Lys Thr Gly Ser 
                 85                  90                  95
Ala Tyr Leu Tyr Ser Tyr Val Thr Val Gly Glu Leu Trp Ala Phe Ile 
             100                105                110
Thr Gly Trp Asn Leu Ile Leu Ser Tyr Ile Ile Gly Thr Ser Ser Val 
         115                120                125
Ala Arg Ala Trp Ser Ala Thr Phe Asp Glu Leu Ile Gly Lys Pro Ile 
     130                135                140
Gly Glu Phe Ser Arg Gln His Met Ala Leu Asn Ala Pro Gly Val Leu 
 145                150                155                160
Ala Gln Thr Pro Asp Ile Phe Ala Val Ile Ile Ile Ile Ile Leu Thr 
                 165                170                175
Gly Leu Leu Thr Leu Gly Val Lys Glu Ser Ala Met Val Asn Lys Ile 
             180                185                190
Phe Thr Cys Ile Asn Val Leu Val Leu Cys Phe Ile Met Val Ser Gly 
         195                200                205
Phe Val Lys Gly Ser Ile Glu Asn Trp Gln Leu Thr Glu Asn Lys Ser 
     210                215                220
Ser Pro Leu Cys Gly Asn Asn Asp Thr Asn Val Lys Tyr Gly Glu Gly 
 225                230                235                240
Gly Phe Met Pro Phe Gly Phe Ser Gly Val Leu Ser Gly Ala Ala Thr 
                 245                250                255
Cys Phe Tyr Ala Phe Val Gly Phe Asp Cys Ile Ala Thr Thr Gly Glu 
             260                265                270
Glu Val Lys Asn Pro Gln Lys Ala Ile Pro Val Gly Ile Val Ala Ser 
         275                280                285
Leu Leu Ile Cys Phe Ile Ala Tyr Phe Gly Val Ser Ala Ala Leu Thr 
     290                295                300
Leu Met Met Pro Tyr Phe Cys Leu Asp Thr Asp Ser Pro Leu Pro Gly 
 305                310                315                320
Ala Phe Lys Tyr Arg Gly Trp Glu Glu Ala Lys Tyr Ala Val Ala Val 
                 325                330                335
Gly Ser Leu Cys Ala Leu Ser Thr Ser Pro Leu Gly Ser Met Phe Pro 
             340                345                350
Met Pro Arg Val Ile Tyr Ala Met Ala Glu Asp Gly Leu Leu Phe Lys 
         355                360                365
Phe Leu Ala Lys Ile Asn Asp Arg Thr Lys Thr Pro Ile Ile Ala Thr 
     370                375                380
Val Thr Ser Gly Ala Ile Ala Ala Val Met Ala Phe Leu Phe Glu Leu 
 385                390                395                400
Lys Asp Leu Val Asp Leu Met Ser Ile Gly Thr Leu Leu Ala Tyr Ser 
                 405                410                415
Leu Val Ala Ala Cys Val Leu Val Leu Arg Tyr Gln Pro Glu Gln Pro 
             420                425                430
Asn Leu Val Tyr Gln Met Ala Arg Thr Thr Asp Glu Leu Asp Gln Val 
         435                440                445
Asp Gln Asn Glu Met Val Ser Ala Ser Glu Ser Gln Thr Gly Phe Leu 
     450                455                460
Pro Ala Ala Glu Lys Phe Ser Leu Lys Thr Ile Leu Ser Pro Lys Asn 
 465                470                475                480
Met Glu Pro Ser Lys Phe Ser Gly Leu Ile Val Asn Ile Ser Ala Gly 
                 485                490                495
Leu Leu Ala Val Leu Ile Ile Thr Val Cys Ile Val Ala Val Leu Gly 
             500                505                510
Arg Glu Ala Leu Ala Glu Gly Thr Leu Trp Ala Val Phe Val Met Thr 
         515                520                525
Gly Ser Val Leu Leu Cys Met Leu Val Thr Gly Ile Ile Trp Arg Gln 
     530                535                540
Pro Glu Ser Lys Thr Lys Leu Ser Phe Lys Val Pro Phe Val Pro Val 
 545                550                555                560
Leu Pro Val Leu Ser Ile Phe Val Asn Ile Tyr Leu Met Met Gln Leu 
                 565                570                575
Asp Gln Gly Thr Trp Val Arg Phe Ala Val Trp Met Leu Ile Ala Phe 
             580                585                590
Ala Ile Tyr Phe Gly Tyr Gly Val Trp His Ser Glu Glu Ala Ser Leu 
         595                600                605
Ala Ala Gly Gln Ala Lys Thr Pro Asp Ser Asn Leu Asp Gln Cys Lys 
     610                615                620



<210> 6430
<211> 2157
<212> DNA
<213> Homo sapiens
<308> X59155
<400> 6430

cgatcctgc  ggagccccg  cgccgccgg  ttggattct  aaaccttcc  tgtatccct  60
ctgagacat  tttgctgca  gatcgaggc  gtcctctgg  gagaaggtg  tgaggcttc  120
cgtcatatt  cagctctga  cagcaacat  gggtgcaaa  tcctgctca  cattgggca  180
cagatgctg  ggcggaagg  ggtggactg  agccgggag  agacgcggc  gtctcgctg  240
ctgaacact  ttgatctgg  ggccctcgg  gtgggcagc  cactgggtg  tggtgtcta  300
gtcctggct  gagctgtgg  ccgtgagaa  gcaggccct  ccattgtca  ctccttcct  360
atcgctgcg  tggcctcag  gctggctgg  ctgtgctat  gcgagtttg  tgctcgggt  420
cccaagacg  gctcagctt  cctctacag  tatgtcacc  ttggagagc  ctgggcctt  480
atcaccggc  ggaacttaa  cctctccta  atcatcggt  cttcaagcg  agcgagggc  540
tggagcgcc  ccttcgacg  gctgatagg  agacccatc  gggagttct  acggacaca  600
atgactctg  acgcccccg  cgtgctggc  gaaaacccc  acatattcg  agtgatcat  660
attctcatc  tgacaggac  tttaactct  ggtgtgaaa  agtcggcca  ggtcaacaa  720
atattcact  gtattaacg  cctggtcct  ggcttcata  tggtgtcag  atttgtgaa  780
ggatcggtt  aaaactggc  gctcacgga  gaggatttt  ggaacacat  aggccgtct  840
tgtttgaac  atgacacaa  agaagggaa  cccggtgtt  gtggattca  gcccttcgg  900
ttctctggt  tcctgtcgg  ggcagcgac  tgcttctat  ccttcgtgg  ctttgactg  960
atcgccacc  caggtgaag  ggtgaagaa  ccacagaag  ccatccccg  ggggatcgt  1020
gcgtccctc  tgatctgct  catcgccta  tttggggtg  cggctgccc  cacgctcat  1080
atgccctac  tctgcctgg  caataacag  cccctgccc  acgccttta  gcacgtggg  1140
tgggaaggt  ccaagtacg  agtggccgt  ggctccctc  gcgctcttt  cgccagtct  1200
ctaggttcc  tgtttccca  gcctcgggt  atctatgcc  tggctgagg  tggactgct  1260
tttaaattc  tagccaacg  caatgatag  accaaaaca  caataatcg  cacattagc  1320
tcgggtgcc  ttgctgctg  gatggcctt  ctctttgac  tgaaggact  ggtggacct  1380
atgtccatt  gcactctcc  ggcttactc  ttggtggct  cctgtgtgt  ggtcttacg  1440
taccagcca  agcagccta  cctggtata  cagatggcc  gtacttccg  cgagttaga  1500
ccagcagac  aaaatgaat  ggcaagcac  aatgattcc  agctggggt  tttaccaga  1560
gcagagatg  tctctttga  aaccatact  tcacccaaa  acatggagc  ttccaaaat  1620
tctgggcta  ttgtgaaca  ttcaaccag  cttatagct  ttctcatca  caccttctg  1680
attgtgacc  tgcttggaa  ggaggctct  accaaaggg  cgctgtggg  agtctttct  1740
ctcgcaggg  ctgccctcc  ctgtgccgt  gtcacgggc  tcatctgga  gcagcccga  1800
agcaagacc  agctctcat  taaggttcc  ttcctgcca  tgctcccca  cctgagcat  1860
ttcgtgaac  tctatctca  gatgcagct  gaccagggc  cctgggtcc  gtttgctgt  1920
tggatgctg  taggcttca  catctactt  ggctatggc  tgtggcaca  cgaggaggc  1980
tccctggat  ccgaccaag  aaggactcc  gacggcaac  tggaccagt  caagtgacg  2040
acagccccg  cccccggag  tggcagcag  cccgaggga  gcccccaga  gaccgggag  2100
caccccacc  tccccacca  tgcaacaga  accacctgc  tccacaccc  cactgca  2157



<210> 6431
<211> 629
<212> PRT
<213> Homo sapiens
<308> P30825
<400> 6431

Met Gly Cys Lys Val Leu Leu Asn Ile Gly Gln Gln Met Leu Arg Arg 
  1               5                  10                  15
Lys Val Val Asp Cys Ser Arg Glu Glu Thr Arg Leu Ser Arg Cys Leu 
             20                  25                  30
Asn Thr Phe Asp Leu Val Ala Leu Gly Val Gly Ser Thr Leu Gly Ala 
         35                  40                  45
Gly Val Tyr Val Leu Ala Gly Ala Val Ala Arg Glu Asn Ala Gly Pro 
     50                  55                  60
Ala Ile Val Ile Ser Phe Leu Ile Ala Ala Leu Ala Ser Val Leu Ala 
 65                  70                  75                  80
Gly Leu Cys Tyr Gly Glu Phe Gly Ala Arg Val Pro Lys Thr Gly Ser 
                 85                  90                  95
Ala Tyr Leu Tyr Ser Tyr Val Thr Val Gly Glu Leu Trp Ala Phe Ile 
             100                105                110
Thr Gly Trp Asn Leu Ile Leu Ser Tyr Ile Ile Gly Thr Ser Ser Val 
         115                120                125
Ala Arg Ala Trp Ser Ala Thr Phe Asp Glu Leu Ile Gly Arg Pro Ile 
     130                135                140
Gly Glu Phe Ser Arg Thr His Met Thr Leu Asn Ala Pro Gly Val Leu 
 145                150                155                160
Ala Glu Asn Pro Asp Ile Phe Ala Val Ile Ile Ile Leu Ile Leu Thr 
                 165                170                175
Gly Leu Leu Thr Leu Gly Val Lys Glu Ser Ala Met Val Asn Lys Ile 
             180                185                190
Phe Thr Cys Ile Asn Val Leu Val Leu Gly Phe Ile Met Val Ser Gly 
         195                200                205
Phe Val Lys Gly Ser Val Lys Asn Trp Gln Leu Thr Glu Glu Asp Phe 
     210                215                220
Gly Asn Thr Ser Gly Arg Leu Cys Leu Asn Asn Asp Thr Lys Glu Gly 
 225                230                235                240
Lys Pro Gly Val Gly Gly Phe Met Pro Phe Gly Phe Ser Gly Val Leu 
                 245                250                255
Ser Gly Ala Ala Thr Cys Phe Tyr Ala Phe Val Gly Phe Asp Cys Ile 
             260                265                270
Ala Thr Thr Gly Glu Glu Val Lys Asn Pro Gln Lys Ala Ile Pro Val 
         275                280                285
Gly Ile Val Ala Ser Leu Leu Ile Cys Phe Ile Ala Tyr Phe Gly Val 
     290                295                300
Ser Ala Ala Leu Thr Leu Met Met Pro Tyr Phe Cys Leu Asp Asn Asn 
 305                310                315                320
Ser Pro Leu Pro Asp Ala Phe Lys His Val Gly Trp Glu Gly Ala Lys 
                 325                330                335
Tyr Ala Val Ala Val Gly Ser Leu Cys Ala Leu Ser Ala Ser Leu Leu 
             340                345                350
Gly Ser Met Phe Pro Met Pro Arg Val Ile Tyr Ala Met Ala Glu Asp 
         355                360                365
Gly Leu Leu Phe Lys Phe Leu Ala Asn Val Asn Asp Arg Thr Lys Thr 
     370                375                380
Pro Ile Ile Ala Thr Leu Ala Ser Gly Ala Val Ala Ala Val Met Ala 
 385                390                395                400
Phe Leu Phe Asp Leu Lys Asp Leu Val Asp Leu Met Ser Ile Gly Thr 
                 405                410                415
Leu Leu Ala Tyr Ser Leu Val Ala Ala Cys Val Leu Val Leu Arg Tyr 
             420                425                430
Gln Pro Glu Gln Pro Asn Leu Val Tyr Gln Met Ala Ser Thr Ser Asp 
         435                440                445
Glu Leu Asp Pro Ala Asp Gln Asn Glu Leu Ala Ser Thr Asn Asp Ser 
     450                455                460
Gln Leu Gly Phe Leu Pro Glu Ala Glu Met Phe Ser Leu Lys Thr Ile 
 465                470                475                480
Leu Ser Pro Lys Asn Met Glu Pro Ser Lys Ile Ser Gly Leu Ile Val 
                 485                490                495
Asn Ile Ser Thr Ser Leu Ile Ala Val Leu Ile Ile Thr Phe Cys Ile 
             500                505                510
Val Thr Val Leu Gly Arg Glu Ala Leu Thr Lys Gly Ala Leu Trp Ala 
         515                520                525
Val Phe Leu Leu Ala Gly Ser Ala Leu Leu Cys Ala Val Val Thr Gly 
     530                535                540
Val Ile Trp Arg Gln Pro Glu Ser Lys Thr Lys Leu Ser Phe Lys Val 
 545                550                555                560
Pro Phe Leu Pro Val Leu Pro Ile Leu Ser Ile Phe Val Asn Val Tyr 
                 565                570                575
Leu Met Met Gln Leu Asp Gln Gly Thr Trp Val Arg Phe Ala Val Trp 
             580                585                590
Met Leu Ile Gly Phe Ile Ile Tyr Phe Gly Tyr Gly Leu Trp His Ser 
         595                600                605
Glu Glu Ala Ser Leu Asp Ala Asp Gln Ala Arg Thr Pro Asp Gly Asn 
     610                615                620
Leu Asp Gln Cys Lys 
 625



<210> 6432
<211> 479
<212> DNA
<213> Rattus norvegicus
<308> AA957961
<400> 6432

ttttttttt  tttttttcc  tcctgggat  gggggcaaa  aactttact  caattagta  60
gtatggtgc  gaatttcat  caaatgaag  gtgccagca  tgtgataat  taaacatat  120
taaacaaaa  acgaatgca  aaaattgct  ctgcttaga  cactgcagc  tctaggacc  180
agtttcttt  actgattta  aaacaaaat  aaaaaaaaa  taataaaaa  gttgtgcct  240
aaatgaatc  tgttttttt  ataagtagc  ccctggttc  agtgccctg  tgaatacag  300
cacttgatc  ttggtgcag  ttctgttca  ctttgtatc  cgggaacgg  ttggcctga  360
ttcttggcc  tcctcttga  ttggcccca  acagggtcc  tggcaagtg  agtgaaggc  420
ttttgtcta  agatgacaa  ggtcagctc  ggggttgtg  cggagggcg  tttcatctt  479



<210> 6433
<211> 798
<212> PRT
<213> Rattus norvegicus
<308> P18395
<400> 6433

Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
  1               5                  10                  15
Pro Asn Gly Thr Ser Ala Ala Leu Arg Glu Thr Gly Val Ile Glu Lys 
             20                  25                  30
Leu Leu Thr Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg 
         35                  40                  45
Leu Phe Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys 
     50                  55                  60
Val Gly Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Thr Gly 
 65                  70                  75                  80
Lys Pro Ile Ala Ile Lys Leu Val Lys Ile Lys Pro Glu Ile His Pro 
                 85                  90                  95
Glu Glu Arg Met Asn Gly Gln Val Val Cys Ala Val Pro His Asn Leu 
             100                105                110
Glu Ser Lys Ser Pro Ala Ala Pro Gly Gln Ser Pro Thr Gly Ser Val 
         115                120                125
Cys Tyr Glu Arg Asn Gly Glu Val Phe Tyr Leu Thr Tyr Thr Ser Glu 
     130                135                140
Asp Val Glu Gly Asn Val Gln Leu Glu Thr Gly Asp Lys Ile Asn Phe 
 145                150                155                160
Val Ile Asp Asn Asn Lys His Thr Gly Ala Val Ser Ala Arg Asn Ile 
                 165                170                175
Met Leu Leu Lys Lys Lys Gln Ala Arg Tyr Gln Gly Val Val Cys Ala 
             180                185                190
Met Lys Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu 
         195                200                205
Ile Phe Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Thr Leu Gln 
     210                215                220
Pro Gly Asp Asp Val Glu Phe Thr Ile Lys Asp Arg Asn Gly Lys Glu 
 225                230                235                240
Val Ala Thr Asp Val Arg Leu Leu Pro Gln Gly Thr Val Ile Phe Glu 
                 245                250                255
Asp Ile Ser Ile Glu His Phe Glu Gly Thr Val Thr Lys Val Ile Pro 
             260                265                270
Lys Val Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile Lys 
         275                280                285
Val Asp Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp Thr 
     290                295                300
Lys Ser Lys Val Thr Leu Leu Glu Gly Asp His Val Arg Phe Asn Ile 
 305                310                315                320
Ser Thr Asp Arg Arg Asp Lys Leu Glu Arg Ala Thr Asn Ile Glu Val 
                 325                330                335
Leu Ser Asn Thr Phe Gln Phe Thr Asn Glu Ala Arg Glu Met Gly Val 
             340                345                350
Ile Ala Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp Arg 
         355                360                365
Asp Ala Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn Gln 
     370                375                380
Leu His Ile Ala Asp Glu Val Glu Phe Thr Val Val Pro Asp Met Leu 
 385                390                395                400
Ser Ala Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys Gly 
                 405                410                415
Thr Val Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Thr Val 
             420                425                430
Glu Lys Glu Ala Thr Phe Ser Asn Pro Lys Thr Thr Ser Pro Asn Lys 
         435                440                445
Gly Lys Asp Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp Cys 
     450                455                460
Gly Val Lys Leu Thr Ile Ala Phe Gln Ala Lys Asp Val Glu Gly Ser 
 465                470                475                480
Thr Ser Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp Lys 
                 485                490                495
Gln Arg Pro Gly Gln Gln Ile Ala Thr Cys Val Arg Leu Leu Gly Arg 
             500                505                510
Asn Ser Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Thr Leu Lys Asp 
         515                520                525
Asn Phe Gly Phe Ile Glu Thr Ala Asn His Asp Lys Glu Ile Phe Phe 
     530                535                540
His Tyr Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly Asp 
 545                550                555                560
Met Val Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser Ala 
                 565                570                575
Glu Lys Val Asn Lys Thr His Ser Val Asn Gly Ile Thr Glu Glu Ala 
             580                585                590
Asn Pro Thr Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Gly Val 
         595                600                605
Asp Pro Thr Gln Ile Glu Tyr Gln Gly Met Ile Glu Ile Val Glu Glu 
     610                615                620
Gly Asp Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met Ala 
 625                630                635                640
Asn Lys Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln Leu 
                 645                650                655
Cys Val Leu Gly Gln Asn Ala Gln Thr Met Ala Tyr Asn Ile Thr Pro 
             660                665                670
Leu Arg Arg Ala Thr Val Glu Cys Val Lys Asp Gln Phe Gly Phe Ile 
         675                680                685
Asn Tyr Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys Glu 
     690                695                700
Val Gln Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe Ser 
 705                710                715                720
Val Ile Leu Asn Gln Arg Thr Gly Lys Cys Ser Ala Cys Asn Val Trp 
                 725                730                735
Arg Val Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp Arg 
             740                745                750
Leu Val Asn Arg Leu Lys Asn Ile Thr Leu Asp Asp Ala Ser Ala Pro 
         755                760                765
Arg Leu Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met Gly 
     770                775                780
Phe Gly Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
 785                790                795



<210> 6434
<211> 2537
<212> DNA
<213> Homo sapiens
<308> AY049788
<400> 6434

gagtatcac  gcgagatga  ctttgatcc  aaccttctc  acaacaatg  acataatgg  60
taccctaat  gtacttcag  agcactgcg  gaaactggg  ttattgaaa  actgttaac  120
tcttacgga  ttattcagt  ttcagaacg  caagctaga  ttttcttcc  ctgttcaca  180
tataatggc  acctgcaag  cttaaaagt  ggagatgat  ttgaatttg  agtatcatc  240
gaccgacgg  ctgggaaac  cattgctgt  aaactggtg  agataaaac  agaaatcct  300
cctgaagaa  gaatgaatg  acaagaagt  ttttatctg  cttacaccc  tgaagatgt  360
gaagggaac  ttcagctgg  aactggaga  aaaataaac  ttgtaattg  taacaataa  420
catactggt  ctgtaagtg  tcgcaacat  atgctgttg  aaaagaaac  agcccgctg  480
cagggagta  tttgtgcca  gaaggaggc  tttggcttt  ttgaaagag  tgatgttgt  540
aaagagata  tctttcact  tagcgaatt  aagggtgac  tagaaacct  acagcctgg  600
gatgatgtg  aattcacaa  caaggacag  aatggtaaa  aagttgcaa  agatgtcag  660
ctattgcct  aaggaacag  catttttga  gatatcagc  ttgaacatt  tgaaggaac  720
gtaaccaaa  ttatcccaa  agtacccag  aaaaaccag  atgacccat  gccaggacg  780
atcaaagtt  actttgtga  ccctaaaga  cttcccttt  gagacaaag  tacgaaatc  840
aaggtgacc  tgctggaag  tgaccatgt  aggtttaat  tttcaacag  ccgacgtga  900
aaattagag  gagcaacca  tatagaagt  ctgtcaaat  catttcagt  cactaatga  960
gcccgagaa  tgggtgtga  tgctgccat  agagatggt  ttggtttca  caagtgtgt  1020
gatcgtgat  ttcgtatgt  cttccactt  agtgaaatt  tggatggga  ccagctcca  1080
attgcagat  aagtagagt  tactgtggt  cctgatatg  tctctgctc  aagaaatca  1140
gctattagg  ttaaaaaac  tcccaaggg  acggtttca  ttcattccc  ttcagatca  1200
cgttttctg  gcacggtag  aaaagaagc  actttttcc  atcctaaaa  cactagccc  1260
aataaaggc  aagagaagg  ggctgagga  ggcattatt  cttatgatg  ctgtggggt  1320
aaactgact  ttgcttttc  agccaagga  gtggaagga  ctacttctc  tcaaatagg  1380
gataaggtt  aatttagta  tagtgacaa  cagaggcct  gacagcagg  tgcaacttg  1440
gtgcgactt  taggtcgta  ttctaactc  aagaggctc  tgggttatg  ggcaactct  1500
aaggataat  ttggattta  tgaaacagc  aatcatgat  aggaaatct  tttccatta  1560
agtgagttc  ctggtgatg  tgatagcct  gaactgggg  acatggtcg  gtatagctt  1620
tccaaaggc  aaggcaaca  agtcagtgc  gaaaaagtg  acaaaacac  ctcagtgaa  1680
ggcattact  aggaagctg  tcccaccat  tactctggc  aagtaattc  ccccctgag  1740
agtgttgat  caacacaga  tgagtacca  ggaatgatt  agattgtgg  ggagggcga  1800
atgaaaggt  aggtctatc  atttggcat  gttgggatg  ccaacaaag  ggattgcct  1860
cagaaaggg  agagcgtca  gttccaatt  tgtgtcctg  gccaaaatg  acaaactat  1920
gcttacaac  tcacacccc  gcgcagggc  acagtggaa  gtgtgaaag  tcagtttgg  1980
ttcattaac  atgaagtag  agatagcaa  aagctcttt  tccatgtga  agaagttca  2040
gatggcatt  agctacagg  aggagatga  gtggagttc  cagtgattc  taatcagcg  2100
actggcaag  gcagcgcct  taatgtttg  cgagtctgg  gagggcccc  aggctgttg  2160
agctcctcg  cctgatcgg  tggtcaatc  cttgaagaa  atcactctg  atgatgcca  2220
tgctcctcg  ctaatggtt  ttcgtcagc  aaggggacc  gataactca  tggggtttg  2280
tgcagaaag  aagatccgt  aagctggtg  cattgacta  ccacatcca  aaagcacac  2340
attaatcca  tatgatcaa  ttgggggga  tctggtgaa  ggttctgaa  atctccctc  2400
tcatccctc  cgaaatctg  aatacttat  ctattgagc  attacacca  ttttaacac  2460
ttcctcgtg  tatgtttaa  aaaataaat  aatttaaga  aaccatttt  aataatgca  2520
agttgcagc  tggaaaa  2537



<210> 6435
<211> 798
<212> PRT
<213> Homo sapiens
<308> O75534
<400> 6435

Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
  1               5                  10                  15
Pro Asn Gly Thr Ser Ala Ala Leu Arg Glu Thr Gly Val Ile Glu Lys 
             20                  25                  30
Leu Leu Thr Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg 
         35                  40                  45
Leu Phe Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys 
     50                  55                  60
Val Gly Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Thr Gly 
 65                  70                  75                  80
Lys Pro Ile Ala Val Lys Leu Val Lys Ile Lys Gln Glu Ile Leu Pro 
                 85                  90                  95
Glu Glu Arg Met Asn Gly Gln Val Val Cys Ala Val Pro His Asn Leu 
             100                105                110
Glu Ser Lys Ser Pro Ala Ala Pro Gly Gln Ser Pro Thr Gly Ser Val 
         115                120                125
Cys Tyr Glu Arg Asn Gly Glu Val Phe Tyr Leu Thr Tyr Thr Pro Glu 
     130                135                140
Asp Val Glu Gly Asn Val Gln Leu Glu Thr Gly Asp Lys Ile Asn Phe 
 145                150                155                160
Val Ile Asp Asn Asn Lys His Thr Gly Ala Val Ser Ala Arg Asn Ile 
                 165                170                175
Met Leu Leu Lys Lys Lys Gln Ala Arg Cys Gln Gly Val Val Cys Ala 
             180                185                190
Met Lys Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu 
         195                200                205
Ile Phe Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Thr Leu Gln 
     210                215                220
Pro Gly Asp Asp Val Glu Phe Thr Ile Lys Asp Arg Asn Gly Lys Glu 
 225                230                235                240
Val Ala Thr Asp Val Arg Leu Leu Pro Gln Gly Thr Val Ile Phe Glu 
                 245                250                255
Asp Ile Ser Ile Glu His Phe Glu Gly Thr Val Thr Lys Val Ile Pro 
             260                265                270
Lys Val Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile Lys 
         275                280                285
Val Asp Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp Thr 
     290                295                300
Lys Ser Lys Val Thr Leu Leu Glu Gly Asp His Val Arg Phe Asn Ile 
 305                310                315                320
Ser Thr Asp Arg Arg Asp Lys Leu Glu Arg Ala Thr Asn Ile Glu Val 
                 325                330                335
Leu Ser Asn Thr Phe Gln Phe Thr Asn Glu Ala Arg Glu Met Gly Val 
             340                345                350
Ile Ala Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp Arg 
         355                360                365
Asp Val Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn Gln 
     370                375                380
Leu His Ile Ala Asp Glu Val Glu Phe Thr Val Val Pro Asp Met Leu 
 385                390                395                400
Ser Ala Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys Gly 
                 405                410                415
Thr Val Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Thr Val 
             420                425                430
Glu Lys Glu Ala Thr Phe Ser Asn Pro Lys Thr Thr Ser Pro Asn Lys 
         435                440                445
Gly Lys Glu Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp Cys 
     450                455                460
Gly Val Lys Leu Thr Ile Ala Phe Gln Ala Lys Asp Val Glu Gly Ser 
 465                470                475                480
Thr Ser Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp Lys 
                 485                490                495
Gln Arg Pro Gly Gln Gln Val Ala Thr Cys Val Arg Leu Leu Gly Arg 
             500                505                510
Asn Ser Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Thr Leu Lys Asp 
         515                520                525
Asn Phe Gly Phe Ile Glu Thr Ala Asn His Asp Lys Glu Ile Phe Phe 
     530                535                540
His Tyr Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly Asp 
 545                550                555                560
Met Val Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser Ala 
                 565                570                575
Glu Lys Val Asn Lys Thr His Ser Val Asn Gly Ile Thr Glu Glu Ala 
             580                585                590
Asp Pro Thr Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Ser Val 
         595                600                605
Asp Pro Thr Gln Thr Glu Tyr Gln Gly Met Ile Glu Ile Val Glu Glu 
     610                615                620
Gly Asp Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met Ala 
 625                630                635                640
Asn Lys Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln Leu 
                 645                650                655
Cys Val Leu Gly Gln Asn Ala Gln Thr Met Ala Tyr Asn Ile Thr Pro 
             660                665                670
Leu Arg Arg Ala Thr Val Glu Cys Val Lys Asp Gln Phe Gly Phe Ile 
         675                680                685
Asn Tyr Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys Glu 
     690                695                700
Val Gln Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe Ser 
 705                710                715                720
Val Ile Leu Asn Gln Arg Thr Gly Lys Cys Ser Ala Cys Asn Val Trp 
                 725                730                735
Arg Val Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp Arg 
             740                745                750
Leu Val Asn Arg Leu Lys Asn Ile Thr Leu Asp Asp Ala Ser Ala Pro 
         755                760                765
Arg Leu Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met Gly 
     770                775                780
Phe Gly Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
 785                790                795



<210> 6436
<211> 473
<212> DNA
<213> Rattus norvegicus
<308> AA963447
<400> 6436

ttttttttt  tttttttga  agtgccatc  tttatttat  ctaattgaa  tttaaatgt  60
cttttgaca  aaaaaggta  atacatgac  cagctacac  acctttttt  actggacaa  120
aagtgtcaa  accctgtgg  tgtataggg  gaaacaaga  tggtcagga  aagagaatt  180
ttcctataa  tgcaatctg  cacaatgtc  tattgccat  aacaaagca  aaaaaaaag  240
tccatttca  tttattcaa  ttttttttc  tggtatttt  tccctcttg  taagaaaaa  300
aaaatcaga  ttttgtaat  tgtgaatgc  gatcttcat  aaaaggttc  ttctctgga  360
cagagtcag  ggtgtcaga  tatctataa  gatcaggtt  attgtcact  acgtctgga  420
tcacagaag  tgaactgct  gcctctgga  ttgatggtt  ctctactgt  ttt  473



<210> 6437
<211> 403
<212> PRT
<213> Rattus norvegicus
<308> NP_113794
<400> 6437

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
  1               5                  10                  15
Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
             20                  25                  30
Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
         35                  40                  45
Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
     50                  55                  60
Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
 65                  70                  75                  80
Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                 85                  90                  95
Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
             100                105                110
Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
         115                120                125
Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
     130                135                140
Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
 145                150                155                160
Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                 165                170                175
Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
             180                185                190
Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
         195                200                205
Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
     210                215                220
Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Leu Met Tyr 
 225                230                235                240
Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                 245                250                255
Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
             260                265                270
Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
         275                280                285
Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
     290                295                300
Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
 305                310                315                320
Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                 325                330                335
Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
             340                345                350
Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
         355                360                365
Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
     370                375                380
Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Ser Gln Ile 
 385                390                395                400
Thr Lys Val 
                 405



<210> 6438
<211> 804
<212> DNA
<213> Homo sapiens
<308> BI823499
<400> 6438

ccgacgagc  ctgcactaa  gcaggatcc  gctgccgaa  gtcctcgcc  gcaggatga  60
gttaaagga  gtagatcgt  cagccatgc  ggcatggag  cctgcccag  atcacccca  120
ttacctagc  acaggaaca  ctgctcagc  attggatgc  acatttagt  cgaatgctt  180
ccttgagat  tttgaatta  acctctctg  tccatcctt  gatatgaaa  cttgtgcca  240
attctcctc  tctcacagg  accacaagt  gatttgggg  ccttataaa  tggattcca  300
aggagatgt  tctggagtt  tgattgcag  tggtgaaaa  ggaaatatt  ttctctatg  360
tccttctaa  attatagct  gagacaagg  agttgtgat  gcccagaat  acaagcata  420
tggcccagt  agagccttg  atgtgaaca  tttccaggt  aagctgtac  tcacaaaaa  480
agtagagga  ccgtcaaat  cagaggcta  cagttcaac  tctgtaaca  cagatgtta  540
tgacaatga  cctgatcat  atagatatt  tgacgacca  tgactctga  ccagagaat  600
aaccttttg  tgaagatca  catacacaa  ttacaaaag  ctgaatttt  ttttatcaa  660
agggataaa  caccatgaa  atcaacttg  ataacctga  aatggacct  ttttttttt  720
aatggcaat  ggacatggt  tcagattac  agttatcgg  acaattctc  tttcctgac  780
aaatcttgt  ttaccctat  catc  804



<210> 6439
<211> 403
<212> PRT
<213> Homo sapiens
<308> NP_000305
<400> 6439

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
  1               5                  10                  15
Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
             20                  25                  30
Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
         35                  40                  45
Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
     50                  55                  60
Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
 65                  70                  75                  80
Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                 85                  90                  95
Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
             100                105                110
Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
         115                120                125
Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
     130                135                140
Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
 145                150                155                160
Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                 165                170                175
Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
             180                185                190
Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
         195                200                205
Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
     210                215                220
Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
 225                230                235                240
Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                 245                250                255
Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
             260                265                270
Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
         275                280                285
Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
     290                295                300
Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
 305                310                315                320
Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                 325                330                335
Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
             340                345                350
Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
         355                360                365
Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
     370                375                380
Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
 385                390                395                400
Thr Lys Val 
                 405



<210> 6440
<211> 386
<212> DNA
<213> Rattus norvegicus
<308> AA963682
<400> 6440

ttttttttt  aatgcagaa  gataaagaa  atcaccttt  ttttttatt  agcatgagc  60
aatttacag  gcatggaga  tcactttca  tcccggcgc  gacacgcgt  cactaagca  120
gtgcaatgt  agatacaag  agccatgtt  ttcagactc  gcctcaagt  atttggtgt  180
actttcgga  aagacagac  gacaacgac  cctgtgcca  cggaaggag  gacagcaca  240
gatggagcg  tcaaatcca  aagacacac  gaaattact  aatccacaa  agctcgcct  300
agttttctt  gacccanac  aactgtcag  gtataaaca  tgtttgttt  ggtccanaa  360
aaacctttg  gggcctcgt  ccgaat  386



<210> 6441
<211> 751
<212> PRT
<213> Rattus norvegicus
<308> P97570
<400> 6441

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
  1               5                  10                  15
Leu Phe Ser Asn Pro Phe Arg Ala Lys Glu Val Ser Leu Ala Asp Tyr 
             20                  25                  30
Ala Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
         35                  40                  45
Asn Ala Ser Asn Arg Thr Trp Asp Cys Asp Leu Val Ser Pro Arg Asn 
     50                  55                  60
Pro Gln Ser Asp Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Val 
 65                  70                  75                  80
Leu Val Asn Phe Gln Gln Tyr Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                 85                  90                  95
Ser Ser Glu Gln Val Leu His Val Glu Val Leu Gln Leu Thr Asp Leu 
             100                105                110
Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu Leu 
         115                120                125
Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Thr Cys Ala Asn 
     130                135                140
Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys Arg 
 145                150                155                160
Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His Ala 
                 165                170                175
Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr Ala 
             180                185                190
Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn Ala 
         195                200                205
Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu His 
     210                215                220
Leu Ala Cys Gln Met Gly Lys Gln Glu Met Val Arg Val Leu Leu Leu 
 225                230                235                240
Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile His 
                 245                250                255
Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile Ser 
             260                265                270
Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala Ser 
         275                280                285
Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu Lys 
     290                295                300
Arg Gly Cys Asp Val Asp Ser Thr Ser Ala Ser Gly Asn Thr Ala Leu 
 305                310                315                320
His Val Ala Val Thr Arg Asn Arg Phe Asp Cys Val Met Val Leu Leu 
                 325                330                335
Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr Pro 
             340                345                350
Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala Leu 
         355                360                365
Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu Thr 
     370                375                380
Pro Ala Phe Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu Met 
 385                390                395                400
Pro Val Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met Arg 
                 405                410                415
Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly Gly 
             420                425                430
Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys Ala 
         435                440                445
Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr Ser 
     450                455                460
Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met Ala 
 465                470                475                480
Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg Gly 
                 485                490                495
Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg Glu 
             500                505                510
Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val Met 
         515                520                525
Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu Phe 
     530                535                540
Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Thr Pro 
 545                550                555                560
Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val Trp 
                 565                570                575
Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro Asn 
             580                585                590
Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu Asp 
         595                600                605
Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys Gly 
     610                615                620
Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly Thr 
 625                630                635                640
Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg Pro 
                 645                650                655
Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu Leu 
             660                665                670
Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala Val 
         675                680                685
Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe Arg 
     690                695                700
Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser Asp 
 705                710                715                720
Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr Glu 
                 725                730                735
Tyr Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
             740                745                750



<210> 6442
<211> 3470
<212> DNA
<213> Homo sapiens
<308> AL136710
<400> 6442

agctttaaa  ggatgtctg  gaagtggtc  aaaggatct  aacctcaat  aagtggggt  60
ttttaaaaa  attttttgg  gggcctgaa  ttttgaaaa  cttcgaact  tgagtgggg  120
aagatgtat  attcctcaa  tgcctacga  gatatcaag  tgctgagag  aattcagcg  180
tggtgaaga  agtggatac  aaccaggga  tggtttcct  gagctgttt  ggaggttga  240
tctaaatca  tgcttaagg  attcctgga  acatcagga  aacatttga  catccaagc  300
tagtggaaa  ggctttacc  cagagtgaa  atgcaatga  cggggacac  gacaaatat  360
ttgggccac  ggaccttaa  gaattgggt  atgattccc  gcctgcaga  ggttacatg  420
gctttagtc  cggagcgcg  tctgccagc  tccgctcct  cagttcgga  gggtcttac  480
ccttgaaca  aagctccta  gcacgggac  gcatgatga  tgaagaact  ctcgtgcca  540
ccaaagagc  gcatctaac  ttcacaagg  aatttgatt  agattctct  agacattac  600
gctgggctg  agacacctt  gacaatgtc  atcttgttc  aagccccat  cattctggg  660
ttctggtta  ctttatggt  gacgcgaga  ggggctcca  gagaggaag  cgtcatcac  720
ggatgagaa  catcattcc  ccacgcaag  gtacggccc  cactcgaat  acctgccgt  780
tggtaaaga  acataaact  gccaaccca  cccccatgg  ggaaggaga  ggattagcc  840
gtaggctgg  agaaatggg  cctgcaggg  cacaatttt  aggccctgt  atagtggaa  900
tccctcact  tgggtccat  agaggaaaa  agagagaac  cattgttct  cgaagtgaa  960
atggtgaaa  ttggaagga  catcagttt  acagcaaaa  tgaagattt  accgagtta  1020
ttaatggca  ggatgaaga  cttgatagc  cagaagagt  agggaaaaa  cgtatctgc  1080
ggattatca  gaaagattt  ccccagtat  ttgcagtgg  ttcccggat  aagcaggaa  1140
gcaaccaga  tggtcctga  ggtggaatt  tgagcagca  cacagtgcc  cttgttcaa  1200
catctttcc  agagggtgc  ctaactaaa  gaattcgag  gggcctcca  gcccagcct  1260
ttccagatg  aattgtgaa  aagatcctt  gaaacaaag  aacttttag  ccaattgtc  1320
ctgtggaac  aagaagacg  aaattccat  aaccaatca  aatgaccat  ccggtgccc  1380
cgccctcag  agaaggtgt  tccaatgga  acaaagggg  cactacacc  aatctgcgt  1440
ttctctgta  cattacagg  ggcacttcg  ctgctcagt  ggaagacat  acaggaaca  1500
ctcctttga  gtttataaa  gattgtgtc  cctttacaa  caatgtttc  gccagattt  1560
ggcttgcag  ctgccatca  gttttagaa  ctgtggggt  agccacgca  ctgtacaga  1620
aattgatat  tgttccata  atggccaag  ttgttgttt  tgccaaaat  aatgatccc  1680
tagaatctt  cttgcgatg  ttctgcatg  cagatgaca  agtggacaa  actttagag  1740
aacaagaga  ttttgagga  gtcgcaaga  gcaaagata  tgaggttct  gaaggaaaa  1800
ctatttatg  tgattgtta  ggaaatttg  ccccactta  caaaggagg  cagcaactt  1860
tttttaact  ttattcttt  aaagaaaat  gactgccat  ttccatcaa  attagagac  1920
ccagccaag  gccctgtgg  cgtctgtct  ttctgaaag  accaaagac  acaaaagga  1980
tgcctcaaa  agcggtttg  aacttaaat  tcactctgc  agcacataa  aagattgag  2040
aaacagatg  acgacagag  ttcgcatcc  tagctttac  taagcgcta  agctacttg  2100
ctgagcctg  aatgagtcc  cagagtcca  gtgaacgga  agatatcag  atggcaata  2160
tagccgatc  cctgggact  agttggaca  aactggcaa  ggaactgaa  ttttcagtg  2220
atgaaatca  tcaaatacg  gtggaaaat  caaattctt  aatttctca  agcttcatg  2280
ttttaaaaa  atgggttac  agagacgga  aaaatgcca  aactgatgc  ttaacttcg  2340
tcttgacaa  aattaatcg  atagatata  tgacactgc  agaaggacc  atatttgat  2400
atggaaata  ttcaggcac  agaagtttt  cagatgaga  caatgtttt  catgaccct  2460
ttgatggtt  tccttccct  caagtggaa  tggaaaccc  cacagggtt  cactacaca  2520
cacctaccc  tttccagca  gatgattat  ttagtgata  ctctagcat  gaatctccc  2580
ttagaaccc  tagtagact  agtgatggg  tagtgcctt  ccaggggaa  atagagcat  2640
ccgcagatg  acctccagt  gtaactgca  aagacgctt  cttagaaga  agcaaactg  2700
aagactcag  gcctttaac  gaaatgcct  aagcagtga  gtagatgag  gccagttgg  2760
gaatgtatg  ctgagttgg  agaatgaga  atcaagtgg  aacctagag  cctgcgctc  2820
agctcgaag  gtaactggt  ggttactag  tcgactgga  gacagccct  accagtgta  2880
agattccat  acctcatat  tcaaaggag  agctggcaa  tttgaagca  atggaagcc  2940
tacagaaat  actccagaa  caaagacaa  atcttactt  ccagaatcc  aaaatgatg  3000
aggaaaaca  agtaccaag  aaactctga  accaaaaat  catggatct  gtcatgttg  3060
agaaccagc  tcaccacta  cagcatatc  gaaatctct  gaagaaacc  gcaagctta  3120
aatagaaga  actaaaccc  gtgtgcctg  cagtatgaa  aagatgagt  ggacttctc  3180
agcagatgg  aagccaagg  ttagcctcc  tgaagaaga  gggtccagt  ggtctgagc  3240
aaagcaggg  gaaggtttt  aggtgaaaa  gaagaaaga  atccggcat  tggaaaaga  3300
gagccactc  taacagcga  cggtcagtc  aggatcata  gtttttact  ccagtattg  3360
gaaattcgt  gaagaaatg  cagcaggaa  taaaaattc  ccgagaagt  tgtgtgtgt  3420
cgctgcttc  acacattaa  ggcatgatt  tttttatgc  aaaaaaaaaa  3470



<210> 6443
<211> 812
<212> PRT
<213> Homo sapiens
<308> AL136710
<400> 6443

Met Ala Leu Pro Gln Ser Glu Asp Ala Met Thr Gly Asp Thr Asp Lys 
  1               5                  10                  15
Tyr Leu Gly Pro Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro 
             20                  25                  30
Ala Glu Gly Tyr Met Gly Phe Ser Leu Gly Ala Arg Ser Ala Ser Leu 
         35                  40                  45
Arg Ser Phe Ser Ser Asp Gly Ser Tyr Thr Leu Asn Arg Ser Ser Tyr 
     50                  55                  60
Ala Arg Asp Ser Met Met Ile Glu Glu Leu Leu Val Pro Ser Lys Glu 
 65                  70                  75                  80
Gln His Leu Thr Phe Thr Arg Glu Phe Asp Ser Asp Ser Leu Arg His 
                 85                  90                  95
Tyr Ser Trp Ala Ala Asp Thr Leu Asp Asn Val Asn Leu Val Pro Ser 
             100                105                110
Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly 
         115                120                125
Gly Ser Met Arg Gly Ser Arg His His Gly Met Arg Ile Ile Ile Pro 
     130                135                140
Pro Arg Lys Cys Thr Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys 
 145                150                155                160
Arg His Lys Leu Ala Asn Pro Pro Pro Met Val Glu Gly Glu Gly Leu 
                 165                170                175
Ala Ser Arg Leu Val Glu Met Gly Pro Ala Gly Ala Gln Phe Leu Gly 
             180                185                190
Pro Val Ile Val Glu Ile Pro His Phe Gly Ser Met Arg Gly Lys Glu 
         195                200                205
Arg Glu Leu Ile Val Leu Arg Ser Glu Asn Gly Glu Thr Trp Lys Glu 
     210                215                220
His Gln Phe Asp Ser Lys Asn Glu Asp Leu Thr Glu Leu Leu Asn Gly 
 225                230                235                240
Met Asp Glu Glu Leu Asp Ser Pro Glu Glu Leu Gly Lys Lys Arg Ile 
                 245                250                255
Cys Arg Ile Ile Thr Lys Asp Phe Pro Gln Tyr Phe Ala Val Val Ser 
             260                265                270
Arg Ile Lys Gln Glu Ser Asn Gln Ile Gly Pro Glu Gly Gly Ile Leu 
         275                280                285
Ser Ser Thr Thr Val Pro Leu Val Gln Ala Ser Phe Pro Glu Gly Ala 
     290                295                300
Leu Thr Lys Arg Ile Arg Val Gly Leu Gln Ala Gln Pro Val Pro Asp 
 305                310                315                320
Glu Ile Val Lys Lys Ile Leu Gly Asn Lys Ala Thr Phe Ser Pro Ile 
                 325                330                335
Val Thr Val Glu Pro Arg Arg Arg Lys Phe His Lys Pro Ile Thr Met 
             340                345                350
Thr Ile Pro Val Pro Pro Pro Ser Gly Glu Gly Val Ser Asn Gly Tyr 
         355                360                365
Lys Gly Asp Thr Thr Pro Asn Leu Arg Leu Leu Cys Ser Ile Thr Gly 
     370                375                380
Gly Thr Ser Pro Ala Gln Trp Glu Asp Ile Thr Gly Thr Thr Pro Leu 
 385                390                395                400
Thr Phe Ile Lys Asp Cys Val Ser Phe Thr Thr Asn Val Ser Ala Arg 
                 405                410                415
Phe Trp Leu Ala Asp Cys His Gln Val Leu Glu Thr Val Gly Leu Ala 
             420                425                430
Thr Gln Leu Tyr Arg Glu Leu Ile Cys Val Pro Tyr Met Ala Lys Phe 
         435                440                445
Val Val Phe Ala Lys Met Asn Asp Pro Val Glu Ser Ser Leu Arg Cys 
     450                455                460
Phe Cys Met Thr Asp Asp Lys Val Asp Lys Thr Leu Glu Gln Gln Glu 
 465                470                475                480
Asn Phe Glu Glu Val Ala Arg Ser Lys Asp Ile Glu Val Leu Glu Gly 
                 485                490                495
Lys Pro Ile Tyr Val Asp Cys Tyr Gly Asn Leu Ala Pro Leu Thr Lys 
             500                505                510
Gly Gly Gln Gln Leu Val Phe Asn Phe Tyr Ser Phe Lys Glu Asn Arg 
         515                520                525
Leu Pro Phe Ser Ile Lys Ile Arg Asp Thr Ser Gln Glu Pro Cys Gly 
     530                535                540
Arg Leu Ser Phe Leu Lys Glu Pro Lys Thr Thr Lys Gly Leu Pro Gln 
 545                550                555                560
Thr Ala Val Cys Asn Leu Asn Ile Thr Leu Pro Ala His Lys Lys Ile 
                 565                570                575
Glu Lys Thr Asp Gly Arg Gln Ser Phe Ala Ser Leu Ala Leu Arg Lys 
             580                585                590
Arg Tyr Ser Tyr Leu Thr Glu Pro Gly Met Ser Pro Gln Ser Pro Cys 
         595                600                605
Glu Arg Thr Asp Ile Arg Met Ala Ile Val Ala Asp His Leu Gly Leu 
     610                615                620
Ser Trp Thr Glu Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile 
 625                630                635                640
Asn Gln Ile Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe 
                 645                650                655
Met Phe Leu Lys Lys Trp Val Thr Arg Asp Gly Lys Asn Ala Thr Thr 
             660                665                670
Asp Ala Leu Thr Ser Val Leu Thr Lys Ile Asn Arg Ile Asp Ile Val 
         675                680                685
Thr Leu Leu Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Thr 
     690                695                700
Arg Ser Phe Ala Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Gly 
 705                710                715                720
Tyr Pro Ser Leu Gln Val Glu Leu Glu Thr Pro Thr Gly Leu His Tyr 
                 725                730                735
Thr Pro Pro Thr Pro Phe Gln Gln Asp Asp Tyr Phe Ser Asp Ile Ser 
             740                745                750
Ser Ile Glu Ser Pro Leu Arg Thr Pro Ser Arg Leu Ser Asp Gly Leu 
         755                760                765
Val Pro Ser Gln Gly Asn Ile Glu His Ser Ala Asp Gly Pro Pro Val 
     770                775                780
Val Thr Ala Glu Asp Ala Ser Leu Glu Asp Ser Lys Leu Glu Asp Ser 
 785                790                795                800
Val Pro Leu Thr Glu Met Pro Glu Ala Val Met Ter 
                 805                810



<210> 6444
<211> 386
<212> DNA
<213> Rattus norvegicus
<308> AA963682
<400> 6444

ttttttttt  aatgcagaa  gataaagaa  atcaccttt  ttttttatt  agcatgagc  60
aatttacag  gcatggaga  tcactttca  tcccggcgc  gacacgcgt  cactaagca  120
gtgcaatgt  agatacaag  agccatgtt  ttcagactc  gcctcaagt  atttggtgt  180
actttcgga  aagacagac  gacaacgac  cctgtgcca  cggaaggag  gacagcaca  240
gatggagcg  tcaaatcca  aagacacac  gaaattact  aatccacaa  agctcgcct  300
agttttctt  gacccanac  aactgtcag  gtataaaca  tgtttgttt  ggtccanaa  360
aaacctttg  gggcctcgt  ccgaat  386



<210> 6445
<211> 751
<212> PRT
<213> Rattus norvegicus
<308> P97570
<400> 6445

Met Gln Phe Phe Gly Arg Leu Val Asn Thr Leu Ser Ser Val Thr Asn 
  1               5                  10                  15
Leu Phe Ser Asn Pro Phe Arg Ala Lys Glu Val Ser Leu Ala Asp Tyr 
             20                  25                  30
Ala Ser Ser Glu Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Leu Gln 
         35                  40                  45
Asn Ala Ser Asn Arg Thr Trp Asp Cys Asp Leu Val Ser Pro Arg Asn 
     50                  55                  60
Pro Gln Ser Asp Phe Arg Leu Phe Gln Leu Glu Ser Glu Ala Asp Val 
 65                  70                  75                  80
Leu Val Asn Phe Gln Gln Tyr Ser Ser Gln Leu Pro Pro Phe Tyr Glu 
                 85                  90                  95
Ser Ser Glu Gln Val Leu His Val Glu Val Leu Gln Leu Thr Asp Leu 
             100                105                110
Ile Arg Asn His Pro Ser Trp Thr Val Thr His Leu Ala Val Glu Leu 
         115                120                125
Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Thr Cys Ala Asn 
     130                135                140
Ser Thr Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys Arg 
 145                150                155                160
Lys Gly Asp Ser Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His Ala 
                 165                170                175
Gln Met Asp Val Thr Asp Asn Lys Gly Glu Thr Ala Phe His Tyr Ala 
             180                185                190
Val Gln Gly Asp Asn Pro Gln Val Leu Gln Leu Leu Gly Lys Asn Ala 
         195                200                205
Ser Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu His 
     210                215                220
Leu Ala Cys Gln Met Gly Lys Gln Glu Met Val Arg Val Leu Leu Leu 
 225                230                235                240
Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Gly Gly Phe Pro Ile His 
                 245                250                255
Thr Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile Ser 
             260                265                270
Met Asp Ser Asn Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala Ser 
         275                280                285
Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu Lys 
     290                295                300
Arg Gly Cys Asp Val Asp Ser Thr Ser Ala Ser Gly Asn Thr Ala Leu 
 305                310                315                320
His Val Ala Val Thr Arg Asn Arg Phe Asp Cys Val Met Val Leu Leu 
                 325                330                335
Thr Tyr Gly Ala Asn Ala Gly Ala Arg Gly Glu His Gly Asn Thr Pro 
             340                345                350
Leu His Leu Ala Met Ser Lys Asp Asn Met Glu Met Val Lys Ala Leu 
         355                360                365
Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu Thr 
     370                375                380
Pro Ala Phe Ile Ala Ser Lys Ile Ser Lys Gln Leu Gln Asp Leu Met 
 385                390                395                400
Pro Val Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Ser Ser Met Arg 
                 405                410                415
Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly Gly 
             420                425                430
Val Lys Gly Leu Val Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys Ala 
         435                440                445
Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr Ser 
     450                455                460
Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met Ala 
 465                470                475                480
Tyr Met Arg Gly Val Tyr Phe Arg Met Lys Asp Glu Val Phe Arg Gly 
                 485                490                495
Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg Glu 
             500                505                510
Phe Gly Glu His Thr Lys Met Thr Asp Val Lys Lys Pro Lys Val Met 
         515                520                525
Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu Phe 
     530                535                540
Arg Asn Tyr Asp Ala Pro Glu Ala Val Arg Glu Pro Arg Cys Thr Pro 
 545                550                555                560
Asn Ile Asn Leu Lys Pro Pro Thr Gln Pro Ala Asp Gln Leu Val Trp 
                 565                570                575
Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro Asn 
             580                585                590
Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu Asp 
         595                600                605
Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Met Ile Arg Lys Gly 
     610                615                620
Gln Gly Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly Thr 
 625                630                635                640
Gly Lys Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg Pro 
                 645                650                655
Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu Leu 
             660                665                670
Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala Val 
         675                680                685
Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe Arg 
     690                695                700
Leu Asn Pro Gln Leu Gly Ser Asp Ile Met Leu Asp Glu Val Ser Asp 
 705                710                715                720
Ala Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr Glu 
                 725                730                735
Tyr Arg Glu Glu Phe Gln Lys Leu Val Gln Leu Leu Leu Ser Pro 
             740                745                750



<210> 6446
<211> 3470
<212> DNA
<213> Homo sapiens
<308> AL136710
<400> 6446

agctttaaa  ggatgtctg  gaagtggtc  aaaggatct  aacctcaat  aagtggggt  60
ttttaaaaa  attttttgg  gggcctgaa  ttttgaaaa  cttcgaact  tgagtgggg  120
aagatgtat  attcctcaa  tgcctacga  gatatcaag  tgctgagag  aattcagcg  180
tggtgaaga  agtggatac  aaccaggga  tggtttcct  gagctgttt  ggaggttga  240
tctaaatca  tgcttaagg  attcctgga  acatcagga  aacatttga  catccaagc  300
tagtggaaa  ggctttacc  cagagtgaa  atgcaatga  cggggacac  gacaaatat  360
ttgggccac  ggaccttaa  gaattgggt  atgattccc  gcctgcaga  ggttacatg  420
gctttagtc  cggagcgcg  tctgccagc  tccgctcct  cagttcgga  gggtcttac  480
ccttgaaca  aagctccta  gcacgggac  gcatgatga  tgaagaact  ctcgtgcca  540
ccaaagagc  gcatctaac  ttcacaagg  aatttgatt  agattctct  agacattac  600
gctgggctg  agacacctt  gacaatgtc  atcttgttc  aagccccat  cattctggg  660
ttctggtta  ctttatggt  gacgcgaga  ggggctcca  gagaggaag  cgtcatcac  720
ggatgagaa  catcattcc  ccacgcaag  gtacggccc  cactcgaat  acctgccgt  780
tggtaaaga  acataaact  gccaaccca  cccccatgg  ggaaggaga  ggattagcc  840
gtaggctgg  agaaatggg  cctgcaggg  cacaatttt  aggccctgt  atagtggaa  900
tccctcact  tgggtccat  agaggaaaa  agagagaac  cattgttct  cgaagtgaa  960
atggtgaaa  ttggaagga  catcagttt  acagcaaaa  tgaagattt  accgagtta  1020
ttaatggca  ggatgaaga  cttgatagc  cagaagagt  agggaaaaa  cgtatctgc  1080
ggattatca  gaaagattt  ccccagtat  ttgcagtgg  ttcccggat  aagcaggaa  1140
gcaaccaga  tggtcctga  ggtggaatt  tgagcagca  cacagtgcc  cttgttcaa  1200
catctttcc  agagggtgc  ctaactaaa  gaattcgag  gggcctcca  gcccagcct  1260
ttccagatg  aattgtgaa  aagatcctt  gaaacaaag  aacttttag  ccaattgtc  1320
ctgtggaac  aagaagacg  aaattccat  aaccaatca  aatgaccat  ccggtgccc  1380
cgccctcag  agaaggtgt  tccaatgga  acaaagggg  cactacacc  aatctgcgt  1440
ttctctgta  cattacagg  ggcacttcg  ctgctcagt  ggaagacat  acaggaaca  1500
ctcctttga  gtttataaa  gattgtgtc  cctttacaa  caatgtttc  gccagattt  1560
ggcttgcag  ctgccatca  gttttagaa  ctgtggggt  agccacgca  ctgtacaga  1620
aattgatat  tgttccata  atggccaag  ttgttgttt  tgccaaaat  aatgatccc  1680
tagaatctt  cttgcgatg  ttctgcatg  cagatgaca  agtggacaa  actttagag  1740
aacaagaga  ttttgagga  gtcgcaaga  gcaaagata  tgaggttct  gaaggaaaa  1800
ctatttatg  tgattgtta  ggaaatttg  ccccactta  caaaggagg  cagcaactt  1860
tttttaact  ttattcttt  aaagaaaat  gactgccat  ttccatcaa  attagagac  1920
ccagccaag  gccctgtgg  cgtctgtct  ttctgaaag  accaaagac  acaaaagga  1980
tgcctcaaa  agcggtttg  aacttaaat  tcactctgc  agcacataa  aagattgag  2040
aaacagatg  acgacagag  ttcgcatcc  tagctttac  taagcgcta  agctacttg  2100
ctgagcctg  aatgagtcc  cagagtcca  gtgaacgga  agatatcag  atggcaata  2160
tagccgatc  cctgggact  agttggaca  aactggcaa  ggaactgaa  ttttcagtg  2220
atgaaatca  tcaaatacg  gtggaaaat  caaattctt  aatttctca  agcttcatg  2280
ttttaaaaa  atgggttac  agagacgga  aaaatgcca  aactgatgc  ttaacttcg  2340
tcttgacaa  aattaatcg  atagatata  tgacactgc  agaaggacc  atatttgat  2400
atggaaata  ttcaggcac  agaagtttt  cagatgaga  caatgtttt  catgaccct  2460
ttgatggtt  tccttccct  caagtggaa  tggaaaccc  cacagggtt  cactacaca  2520
cacctaccc  tttccagca  gatgattat  ttagtgata  ctctagcat  gaatctccc  2580
ttagaaccc  tagtagact  agtgatggg  tagtgcctt  ccaggggaa  atagagcat  2640
ccgcagatg  acctccagt  gtaactgca  aagacgctt  cttagaaga  agcaaactg  2700
aagactcag  gcctttaac  gaaatgcct  aagcagtga  gtagatgag  gccagttgg  2760
gaatgtatg  ctgagttgg  agaatgaga  atcaagtgg  aacctagag  cctgcgctc  2820
agctcgaag  gtaactggt  ggttactag  tcgactgga  gacagccct  accagtgta  2880
agattccat  acctcatat  tcaaaggag  agctggcaa  tttgaagca  atggaagcc  2940
tacagaaat  actccagaa  caaagacaa  atcttactt  ccagaatcc  aaaatgatg  3000
aggaaaaca  agtaccaag  aaactctga  accaaaaat  catggatct  gtcatgttg  3060
agaaccagc  tcaccacta  cagcatatc  gaaatctct  gaagaaacc  gcaagctta  3120
aatagaaga  actaaaccc  gtgtgcctg  cagtatgaa  aagatgagt  ggacttctc  3180
agcagatgg  aagccaagg  ttagcctcc  tgaagaaga  gggtccagt  ggtctgagc  3240
aaagcaggg  gaaggtttt  aggtgaaaa  gaagaaaga  atccggcat  tggaaaaga  3300
gagccactc  taacagcga  cggtcagtc  aggatcata  gtttttact  ccagtattg  3360
gaaattcgt  gaagaaatg  cagcaggaa  taaaaattc  ccgagaagt  tgtgtgtgt  3420
cgctgcttc  acacattaa  ggcatgatt  tttttatgc  aaaaaaaaaa  3470



<210> 6447
<211> 812
<212> PRT
<213> Homo sapiens
<308> AL136710
<400> 6447

Met Ala Leu Pro Gln Ser Glu Asp Ala Met Thr Gly Asp Thr Asp Lys 
  1               5                  10                  15
Tyr Leu Gly Pro Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro 
             20                  25                  30
Ala Glu Gly Tyr Met Gly Phe Ser Leu Gly Ala Arg Ser Ala Ser Leu 
         35                  40                  45
Arg Ser Phe Ser Ser Asp Gly Ser Tyr Thr Leu Asn Arg Ser Ser Tyr 
     50                  55                  60
Ala Arg Asp Ser Met Met Ile Glu Glu Leu Leu Val Pro Ser Lys Glu 
 65                  70                  75                  80
Gln His Leu Thr Phe Thr Arg Glu Phe Asp Ser Asp Ser Leu Arg His 
                 85                  90                  95
Tyr Ser Trp Ala Ala Asp Thr Leu Asp Asn Val Asn Leu Val Pro Ser 
             100                105                110
Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly 
         115                120                125
Gly Ser Met Arg Gly Ser Arg His His Gly Met Arg Ile Ile Ile Pro 
     130                135                140
Pro Arg Lys Cys Thr Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys 
 145                150                155                160
Arg His Lys Leu Ala Asn Pro Pro Pro Met Val Glu Gly Glu Gly Leu 
                 165                170                175
Ala Ser Arg Leu Val Glu Met Gly Pro Ala Gly Ala Gln Phe Leu Gly 
             180                185                190
Pro Val Ile Val Glu Ile Pro His Phe Gly Ser Met Arg Gly Lys Glu 
         195                200                205
Arg Glu Leu Ile Val Leu Arg Ser Glu Asn Gly Glu Thr Trp Lys Glu 
     210                215                220
His Gln Phe Asp Ser Lys Asn Glu Asp Leu Thr Glu Leu Leu Asn Gly 
 225                230                235                240
Met Asp Glu Glu Leu Asp Ser Pro Glu Glu Leu Gly Lys Lys Arg Ile 
                 245                250                255
Cys Arg Ile Ile Thr Lys Asp Phe Pro Gln Tyr Phe Ala Val Val Ser 
             260                265                270
Arg Ile Lys Gln Glu Ser Asn Gln Ile Gly Pro Glu Gly Gly Ile Leu 
         275                280                285
Ser Ser Thr Thr Val Pro Leu Val Gln Ala Ser Phe Pro Glu Gly Ala 
     290                295                300
Leu Thr Lys Arg Ile Arg Val Gly Leu Gln Ala Gln Pro Val Pro Asp 
 305                310                315                320
Glu Ile Val Lys Lys Ile Leu Gly Asn Lys Ala Thr Phe Ser Pro Ile 
                 325                330                335
Val Thr Val Glu Pro Arg Arg Arg Lys Phe His Lys Pro Ile Thr Met 
             340                345                350
Thr Ile Pro Val Pro Pro Pro Ser Gly Glu Gly Val Ser Asn Gly Tyr 
         355                360                365
Lys Gly Asp Thr Thr Pro Asn Leu Arg Leu Leu Cys Ser Ile Thr Gly 
     370                375                380
Gly Thr Ser Pro Ala Gln Trp Glu Asp Ile Thr Gly Thr Thr Pro Leu 
 385                390                395                400
Thr Phe Ile Lys Asp Cys Val Ser Phe Thr Thr Asn Val Ser Ala Arg 
                 405                410                415
Phe Trp Leu Ala Asp Cys His Gln Val Leu Glu Thr Val Gly Leu Ala 
             420                425                430
Thr Gln Leu Tyr Arg Glu Leu Ile Cys Val Pro Tyr Met Ala Lys Phe 
         435                440                445
Val Val Phe Ala Lys Met Asn Asp Pro Val Glu Ser Ser Leu Arg Cys 
     450                455                460
Phe Cys Met Thr Asp Asp Lys Val Asp Lys Thr Leu Glu Gln Gln Glu 
 465                470                475                480
Asn Phe Glu Glu Val Ala Arg Ser Lys Asp Ile Glu Val Leu Glu Gly 
                 485                490                495
Lys Pro Ile Tyr Val Asp Cys Tyr Gly Asn Leu Ala Pro Leu Thr Lys 
             500                505                510
Gly Gly Gln Gln Leu Val Phe Asn Phe Tyr Ser Phe Lys Glu Asn Arg 
         515                520                525
Leu Pro Phe Ser Ile Lys Ile Arg Asp Thr Ser Gln Glu Pro Cys Gly 
     530                535                540
Arg Leu Ser Phe Leu Lys Glu Pro Lys Thr Thr Lys Gly Leu Pro Gln 
 545                550                555                560
Thr Ala Val Cys Asn Leu Asn Ile Thr Leu Pro Ala His Lys Lys Ile 
                 565                570                575
Glu Lys Thr Asp Gly Arg Gln Ser Phe Ala Ser Leu Ala Leu Arg Lys 
             580                585                590
Arg Tyr Ser Tyr Leu Thr Glu Pro Gly Met Ser Pro Gln Ser Pro Cys 
         595                600                605
Glu Arg Thr Asp Ile Arg Met Ala Ile Val Ala Asp His Leu Gly Leu 
     610                615                620
Ser Trp Thr Glu Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile 
 625                630                635                640
Asn Gln Ile Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe 
                 645                650                655
Met Phe Leu Lys Lys Trp Val Thr Arg Asp Gly Lys Asn Ala Thr Thr 
             660                665                670
Asp Ala Leu Thr Ser Val Leu Thr Lys Ile Asn Arg Ile Asp Ile Val 
         675                680                685
Thr Leu Leu Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Thr 
     690                695                700
Arg Ser Phe Ala Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Gly 
 705                710                715                720
Tyr Pro Ser Leu Gln Val Glu Leu Glu Thr Pro Thr Gly Leu His Tyr 
                 725                730                735
Thr Pro Pro Thr Pro Phe Gln Gln Asp Asp Tyr Phe Ser Asp Ile Ser 
             740                745                750
Ser Ile Glu Ser Pro Leu Arg Thr Pro Ser Arg Leu Ser Asp Gly Leu 
         755                760                765
Val Pro Ser Gln Gly Asn Ile Glu His Ser Ala Asp Gly Pro Pro Val 
     770                775                780
Val Thr Ala Glu Asp Ala Ser Leu Glu Asp Ser Lys Leu Glu Asp Ser 
 785                790                795                800
Val Pro Leu Thr Glu Met Pro Glu Ala Val Met Ter 
                 805                810



<210> 6448
<211> 407
<212> DNA
<213> Rattus norvegicus
<308> AA963857
<400> 6448

cggccgcaa  ggttttttt  tcctggtgc  ctgacttgc  agtgtccca  tgcctgtgc  60
gccctgcag  accttgtgg  cctcctaca  aaagggagc  accttcttt  ttcttttct  120
ttttttttt  ttaccttgt  tgcctcctc  caccgccat  aagtaggag  ctaaccacg  180
gttatgttt  cgaaaatca  atggtatct  tatgaggaa  gtaaatttt  gtggtagga  240
agattgtct  ttttgcaaa  aaaaaaaac  aaaaaaatt  aagttgtgc  aaattattt  300
cttacattt  actgctgga  catggttgt  atgtttccc  cttttctct  tctctgcat  360
gatttcttt  acaaaaaaa  taaataaac  ttcaaatcc  cgtgccg  407



<210> 6449
<211> 597
<212> PRT
<213> Rattus norvegicus
<308> P13265
<400> 6449

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Leu Val Ala Met Leu Leu 
  1               5                  10                  15
Gly Leu Gly Cys Leu Gly Gln Ala Gln Pro Pro Pro Pro Pro Asp Ala 
             20                  25                  30
Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly Leu 
         35                  40                  45
Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val Cys 
     50                  55                  60
Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys Tyr 
 65                  70                  75                  80
Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala Ser 
                 85                  90                  95
Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln Glu 
             100                105                110
Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala Met 
         115                120                125
Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe Val 
     130                135                140
Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp Ile 
 145                150                155                160
Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro Val 
                 165                170                175
Ile Tyr Thr Gln Met Met Asn Pro Gly Leu Pro Glu Ser Val Leu Asp 
             180                185                190
Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe Gly 
         195                200                205
Ser Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln Val 
     210                215                220
Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile Asn 
 225                230                235                240
Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu Thr 
                 245                250                255
Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys Pro 
             260                265                270
Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly Val 
         275                280                285
Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu Glu 
     290                295                300
Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu Leu 
 305                310                315                320
Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys Asn 
                 325                330                335
Gly Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser Gln 
             340                345                350
Gln Arg Gln Tyr Arg Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile Asp 
         355                360                365
Lys Lys Val Leu Lys Val Ala Arg Val Glu His Glu Glu Thr Leu Ser 
     370                375                380
Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser Phe 
 385                390                395                400
Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala Glu 
                 405                410                415
Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr Ser 
             420                425                430
Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His Glu 
         435                440                445
Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp Lys 
     450                455                460
Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Val Pro Lys Gly 
 465                470                475                480
Lys Val Val Asp Lys Ser Leu Asp Glu Glu Gly Leu Glu Ser Gly Asp 
                 485                490                495
Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Ser Ser Gly Asp Gly Met 
             500                505                510
Met Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr Asp 
         515                520                525
Leu Asp Val Asp Asp Ala Pro Gly Asn Lys Gln His Gly Asn Gln Lys 
     530                535                540
Asp Asn Glu Ile Thr Thr Ser His Ser Val Gly Asn Met Pro Ser Pro 
 545                550                555                560
Leu Lys Ile Leu Ile Ser Val Ala Ile Tyr Val Ala Cys Phe Phe Ser 
                 565                570                575
Trp Cys Thr Asp Leu Pro Cys Pro Cys Leu Cys Cys Pro Ala Ala Pro 
             580                585                590
Cys Gly Pro Pro Thr 
         595



<210> 6450
<211> 2130
<212> DNA
<213> Homo sapiens
<308> L47125
<400> 6450

gcgcccagg  agctgcgag  aaacttttg  agcggctgg  tagcagcac  tctcttgct  60
ctcagggcc  ctgccaggc  tgccgagtc  tgggactgc  ctcgctccg  ctgccactc  120
cccgcgctc  cctagctcc  tgcgaagca  gatggccgg  accgtgcgc  ccgcgtgct  180
ggtggtggc  atgctgctc  gcttggact  cccgggaca  gcgcagccc  cgccgccgc  240
gccggacgc  acctgtcac  aagtccgct  cttcttcca  agactgcag  ccggactca  300
gtgggtgcc  gaaactccc  tgccaggat  agatttgca  gtatgtctc  ctaagggcc  360
aacatgctg  tcaagaaag  tggaagaaa  ataccaact  acagcacga  tgaacatgg  420
acagctgct  cagtctgca  gtatggagc  caagttctt  attattcag  atgctgcgg  480
tttccaaga  gcctttgaa  ttgttgttc  ccatgccaa  aactacacc  atgccatgt  540
caagaacaa  tacccaagc  tgactccac  agcttttga  tttgtgggt  aatttttca  600
agatgtgtc  ctctacatc  tgggttctg  catcaatgt  gatgacatg  tcaatgaat  660
gtttgacag  ctgtttcca  tcatctata  ccagctaat  aacccaggc  tgcctgatt  720
agccttgga  atcaatgag  gcctccgag  agcaagacg  gacctgaaa  tatttggga  780
tttccccaa  cttattatg  cccaggttt  caagtcact  caagtcact  ggatcttcc  840
tcaggctct  aatcttgga  ttgaagtga  caacacaac  gatcacctg  agttcagta  900
ggactgtgg  cgaatgctc  ccagaatgt  gtactgctc  tactgccag  gactgatga  960
ggttaaacc  tgtggcggt  actgcaatg  ggtcatgca  ggctgtatg  caggtgtgg  1020
ggagattga  aagtactgg  gagaataca  tctgtccct  gaagaactt  tgaatggca  1080
gtacagaat  tatgacatg  agaacgtac  gcttggtct  ttttcaaca  tccatgatt  1140
tatccagta  gtccagaag  atgcaggaa  gctgaccac  actattggc  agttatgtg  1200
ccattctca  caacgccaa  atagatctg  ttattatcc  gaagatctc  ttattgaca  1260
gaaagtatt  aaagttgct  atgtagaac  tgaagaaac  ttatccagc  gaagaaggg  1320
actaattca  aagttgaag  ctttcatca  cttctatag  gctttgcct  gctacatct  1380
cagccatag  cctgtggcg  aaaacgaca  cctttgctg  aatggacaa  aactcgtgg  1440
gagatacag  caaaaggca  caaggaatg  aatgaaaaa  cagttcaat  tccatgagc  1500
gaaaatgaa  ggccctgag  cagtggtca  tcaaattat  gacaaactg  agcacatta  1560
ccagctcct  agaaccatg  ctatgccca  aggtagagt  ctggataaa  acctggatg  1620
ggaagggtt  gaaagtgga  actgcggtg  tgatgaaga  gagtgcatt  gaggctctg  1680
tgatggaat  ataaaagtg  agaatcagc  ccgcttcct  gcagaactg  cctatgatc  1740
ggatgtgga  gatgcgcct  gaaacagtc  gcaggcaac  ccgaaggac  acgagataa  1800
cacctttca  aacctcggg  acgttcatt  cccgctgaa  cttctcacc  gcatggcca  1860
ctcggtggt  tgcttcttc  tcctggtgc  ctgactgcc  ggtgcccag  acatgtgct  1920
ccctacagc  ccctgtggt  ttcctcgat  aagggaacc  ctttcttat  tttttctat  1980
ttttttttt  tgttatcct  tatacctcc  ccagccatg  agtagagga  taaccatgt  2040
ttatgtttt  gaaaatcaa  tggtatctt  tggaggaag  tacatttta  tggtagcat  2100
tagattgtc  ttttgcaaa  aaaaaaaccg  2130



<210> 6451
<211> 580
<212> PRT
<213> Homo sapiens
<308> P51654
<400> 6451

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
  1               5                  10                  15
Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
             20                  25                  30
Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
         35                  40                  45
Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
     50                  55                  60
Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
 65                  70                  75                  80
Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                 85                  90                  95
Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
             100                105                110
Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
         115                120                125
Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
     130                135                140
Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
 145                150                155                160
Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                 165                170                175
Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
             180                185                190
Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
         195                200                205
Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
     210                215                220
Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
 225                230                235                240
Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                 245                250                255
Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
             260                265                270
Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
         275                280                285
Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
     290                295                300
Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
 305                310                315                320
Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                 325                330                335
Asn Ala Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser 
             340                345                350
Gln Gln Arg Gln Tyr Arg Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile 
         355                360                365
Asp Lys Lys Val Leu Lys Val Ala His Val Glu His Glu Glu Thr Leu 
     370                375                380
Ser Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser 
 385                390                395                400
Phe Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala 
                 405                410                415
Glu Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr 
             420                425                430
Ser Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His 
         435                440                445
Glu Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp 
     450                455                460
Lys Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Met Pro Lys 
 465                470                475                480
Gly Arg Val Leu Asp Lys Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly 
                 485                490                495
Asp Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly 
             500                505                510
Met Ile Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr 
         515                520                525
Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser Gln Gln Ala Thr Pro 
     530                535                540
Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val His Ser 
 545                550                555                560
Pro Leu Lys Leu Leu Thr Ser Met Ala Ile Ser Val Val Cys Phe Phe 
                 565                570                575
Phe Leu Val His 
             580



<210> 6452
<211> 450
<212> DNA
<213> Rattus norvegicus
<308> AA965154
<400> 6452

ttttttttt  tttactgct  ggacgcgga  cgagaagct  agagagtcg  agacgctat  60
cgcttccat  cgtcgtgca  accctgccg  agccgctgc  gctatggat  atcgggagg  120
tctggtgta  caggcgaag  tggcagagc  ggccgagcg  tacgacgaa  tggtggaat  180
aatgaagaa  gtagcagga  tggacgtgg  gctgacagt  gaagaacga  accttttat  240
tgttgcata  aaaaatgtg  ttggagcca  aagaacatc  tggagaata  tcagcagca  300
tgaacagaa  gaagaaaac  agggaggag  ggacaaatt  aagatgatt  cggagtacc  360
gcaaatggt  gaaactgag  tcaagttaa  ctgttgtga  attctggat  tactggaca  420
gcacctcat  ccagcagct  acactggcga  450



<210> 6453
<211> 255
<212> PRT
<213> Rattus norvegicus
<308> P42655
<400> 6453

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
  1               5                  10                  15
Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
             20                  25                  30
Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
         35                  40                  45
Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
     50                  55                  60
Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
 65                  70                  75                  80
Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                 85                  90                  95
Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
             100                105                110
Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
         115                120                125
His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
     130                135                140
Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
 145                150                155                160
Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                 165                170                175
Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
             180                185                190
Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
         195                200                205
Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
     210                215                220
Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
 225                230                235                240
Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                 245                250                255



<210> 6454
<211> 1723
<212> DNA
<213> Homo sapiens
<308> BC000179
<400> 6454

gtcgcgcag  ccctgccgg  gccgctgcc  ctatggatg  tcgagagga  ctggtgtac  60
aggcgaagc  ggccgagca  gctgagcga  acgacgaaa  ggtggagtc  atgaagaaa  120
tagcaggga  ggatgtgga  ctgacagtt  aagaaagaa  cctcctatc  gttgcatat  180
agaatgtga  tggagctag  agagcctcc  ggagaataa  cagcagcat  gaacagaaa  240
aagaaaaca  gggaggaga  gacaagcta  aaatgattc  ggaatatcg  caaatggtt  300
agactgagc  aaagttaat  tgttgtgac  ttctggatg  actggacaa  cacctcatt  360
cagcagcta  cactggcga  tccaaggtt  tctattata  aatgaaagg  gactaccac  420
ggtatctgg  agaatttgc  acaggaaac  acaggaagg  ggctgcgga  aacagccta  480
tggcttata  agctgctag  gatattgca  tgacagaac  tccaccaac  catcctatt  540
gcttaggtc  tgctctcaa  ttttccgta  tctactacg  aattcttaa  tcccctgac  600
gtgcctgca  gttggcaaa  gcagctttt  atgatgcaa  tgcagaact  gatacgctg  660
gtgaagaaa  ctataagga  tctacactt  tcatgcagt  gttacgtga  aatctgaca  720
tatggactt  agacatgca  ggtgacggt  aagagcaga  taaagaagc  ctgcaggac  780
tggaagacg  aaatcagtg  gacataagc  aacaagaga  accatctct  accaccccc  840
cctccccat  ccacccttt  gaaactccc  attgtcact  agaaccacc  aatctgact  900
ttacatttg  tctcagaat  taggttcct  ccctgttgg  ttttttttt  tttttttta  960
acagttttc  aaagttctt  aaggcaaga  tgaatttct  tggatttta  tggtcccag  1020
ttttaggtt  tttaagaca  taacaggac  acatagagg  tttttcagc  ttactgtgt  1080
gtctccgtg  cagatgtgg  aagatcacc  ttagcaaat  gaaattaca  ttgaaagcc  1140
ttagactta  aggtgatgc  agcatctaa  agagaggtt  atcacacta  agaggcata  1200
gtggtatca  ttttcattt  tctaattgt  taaactgtg  tttatacca  tgtttgcaa  1260
taattgggt  ttagcttga  atggttaaa  gtggtttgg  gagggactt  gttgtaatg  1320
ttttgctgt  aaaaatgtt  ccaactccg  tgaaatgtt  ctgaaaagc  tggtgctgg  1380
aacagttca  caatccgtg  ctgctcatt  ttgcctact  tactctccc  ctgaagcag  1440
ttagcgttg  aggtggtat  gaaaagcct  catgcctgt  caattcttt  gtttcttct  1500
cttccccct  cccctacct  cttcccctc  ctcctcccc  ccttcgctc  ctcaacctc  1560
tttgttcag  atgtgtaac  tgaagctaa  ttgtactac  ggatatctg  ctggagcca  1620
agatacaga  tctgtattg  tcttactga  acacagcat  gaattaaca  taaacttaa  1680
taaaacaaa  ctaaattaa  aatgccaaa  aaaaaaaaa  aaa  1723



<210> 6455
<211> 255
<212> PRT
<213> Homo sapiens
<308> P42655
<400> 6455

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
  1               5                  10                  15
Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
             20                  25                  30
Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
         35                  40                  45
Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
     50                  55                  60
Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
 65                  70                  75                  80
Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                 85                  90                  95
Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
             100                105                110
Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
         115                120                125
His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
     130                135                140
Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
 145                150                155                160
Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                 165                170                175
Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
             180                185                190
Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
         195                200                205
Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
     210                215                220
Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
 225                230                235                240
Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                 245                250                255



<210> 6456
<211> 365
<212> DNA
<213> Rattus norvegicus
<308> AA997614
<400> 6456

ttttttttt  tttttttcc  ggaaaactg  atttggcac  tcgtatgca  ctcccttcc  60
aaacacggg  gttgtcagc  gaccgtaga  ctcttccgc  ttcaggtct  cgttcttac  120
gttgaagag  agggcggct  cgtcactcc  caaaaggta  gtgaaagtc  tgcccacca  180
ggtaaagct  aacacaggt  cgtacttct  atatgcatt  tccaggaac  caattggac  240
tttcccaaa  gctatcgcg  ggccaagga  cggaattgg  gagtaaata  atggcggac  300
tttcgctcc  gcgggcagc  ggaccatgt  gcccactgc  aggcggaac  ggtagacaa  360
gctaa  365



<210> 6457
<211> 503
<212> PRT
<213> Rattus norvegicus
<308> Q64654
<400> 6457

Met Val Leu Leu Gly Leu Leu Gln Ser Gly Gly Ser Val Leu Gly Gln 
  1               5                  10                  15
Ala Met Glu Gln Val Thr Gly Gly Asn Leu Leu Ser Thr Leu Leu Ile 
             20                  25                  30
Ala Cys Ala Phe Thr Leu Ser Leu Val Tyr Leu Phe Arg Leu Ala Val 
         35                  40                  45
Gly His Met Val Gln Leu Pro Ala Gly Ala Lys Ser Pro Pro Tyr Ile 
     50                  55                  60
Tyr Ser Pro Ile Pro Phe Leu Gly His Ala Ile Ala Phe Gly Lys Ser 
 65                  70                  75                  80
Pro Ile Glu Phe Leu Glu Asn Ala Tyr Glu Lys Tyr Gly Pro Val Phe 
                 85                  90                  95
Ser Phe Thr Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp 
             100                105                110
Ala Ala Ala Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu 
         115                120                125
Glu Val Tyr Gly Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala 
     130                135                140
Tyr Asp Val Pro Asn Ala Val Phe Leu Glu Gln Lys Lys Ile Leu Lys 
 145                150                155                160
Ser Gly Leu Asn Ile Ala His Phe Lys Gln Tyr Val Ser Ile Ile Glu 
                 165                170                175
Lys Glu Ala Lys Glu Tyr Phe Lys Ser Trp Gly Glu Ser Gly Glu Arg 
             180                185                190
Asn Val Phe Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His 
         195                200                205
Cys Leu His Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala 
     210                215                220
Gln Leu Tyr Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu 
 225                230                235                240
Leu Pro Gly Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala 
                 245                250                255
His Arg Glu Ile Lys Asn Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg 
             260                265                270
Leu Ser Lys Glu Pro Ala Glu Asp Ile Leu Gln Thr Leu Leu Asp Ser 
         275                280                285
Thr Tyr Lys Asp Gly Arg Pro Leu Thr Asp Asp Glu Ile Ala Gly Met 
     290                295                300
Leu Ile Gly Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser 
 305                310                315                320
Ala Trp Met Gly Phe Phe Leu Ala Arg Asp Lys Pro Leu Gln Asp Lys 
                 325                330                335
Cys Tyr Leu Glu Gln Lys Thr Val Cys Gly Glu Asp Leu Pro Pro Leu 
             340                345                350
Thr Tyr Glu Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys 
         355                360                365
Glu Thr Leu Arg Leu Arg Pro Pro Ile Met Thr Met Met Arg Met Ala 
     370                375                380
Lys Thr Pro Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln 
 385                390                395                400
Val Cys Val Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val 
                 405                410                415
Glu Arg Leu Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala 
             420                425                430
Ser Gly Glu Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg 
         435                440                445
Cys Ile Gly Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser 
     450                455                460
Thr Met Leu Arg Leu Tyr Glu Phe Asp Leu Ile Asn Gly Tyr Phe Pro 
 465                470                475                480
Ser Val Asn Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile 
                 485                490                495
Arg Tyr Lys Arg Arg Ser Lys 
             500



<210> 6458
<211> 798
<212> DNA
<213> Homo sapiens
<308> BG567904
<400> 6458

gttcaaatt  agacaattt  gtccactat  cttcgttta  atgaatttg  tctcattga  60
ggatacttt  ccactgtga  ttatacaac  atgattcac  cccctgaaa  cccagttat  120
cgttacaaa  gaagatcaa  atgaaaaag  ttgcaagga  cgaatatat  tgattatca  180
tgtaagcca  aaaggcatt  gaagagaat  aagtgtaca  aacaactct  gtagtttac  240
gttttttta  gtgtgtaat  ctaaaagcc  gtttatgat  taggattgt  ttaactgaa  300
ggttctatc  aatataata  catttgaaa  attttctaa  agttatgat  cttatacat  360
tgctttcag  aagttcctt  gtgaaacaa  tgttcaggg  ggatctagg  aattggcag  420
ttctaaata  tataatttc  agatagtaa  tttaagagt  ctcatcgct  ttgccaaat  480
agttcaggg  attcaaatc  tggactagt  ctgcaaggg  acaaaagaa  aaaaatccc  540
gtgagatac  tggaaacca  agtttatta  tatttatct  ggcaattat  tgtgtgtga  600
gatggaagg  tagggaata  tcgaacatc  aaagccttg  ataagagaa  actaattgt  660
gggtatgat  atactcaga  attggagat  ttataggga  aaagaaatc  ttgggaatt  720
taactaaaa  tcactgata  gagaacatt  ggagatcca  ggacatata  ggataagaa  780
ttctaaaat  atggtaat  798



<210> 6459
<211> 503
<212> PRT
<213> Homo sapiens
<308> Q16850
<400> 6459

Met Leu Leu Leu Gly Leu Leu Gln Ala Gly Gly Ser Val Leu Gly Gln 
  1               5                  10                  15
Ala Met Glu Lys Val Thr Gly Gly Asn Leu Leu Ser Met Leu Leu Ile 
             20                  25                  30
Ala Cys Ala Phe Thr Leu Ser Leu Val Tyr Leu Ile Arg Leu Ala Ala 
         35                  40                  45
Gly His Leu Val Gln Leu Pro Ala Gly Val Lys Ser Pro Pro Tyr Ile 
     50                  55                  60
Phe Ser Pro Ile Pro Phe Leu Gly His Ala Ile Ala Phe Gly Lys Ser 
 65                  70                  75                  80
Pro Ile Glu Phe Leu Glu Asn Ala Tyr Glu Lys Tyr Gly Pro Val Phe 
                 85                  90                  95
Ser Phe Thr Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp 
             100                105                110
Ala Ala Ala Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu 
         115                120                125
Asp Val Tyr Ser Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala 
     130                135                140
Tyr Asp Val Pro Asn Pro Val Phe Leu Glu Gln Lys Lys Met Leu Lys 
 145                150                155                160
Ser Gly Leu Asn Ile Ala His Phe Lys Gln His Val Ser Ile Ile Glu 
                 165                170                175
Lys Glu Thr Lys Glu Tyr Phe Glu Ser Trp Gly Glu Ser Gly Glu Lys 
             180                185                190
Asn Val Phe Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His 
         195                200                205
Cys Leu His Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala 
     210                215                220
Gln Leu Tyr Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu 
 225                230                235                240
Leu Pro Gly Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala 
                 245                250                255
His Arg Glu Ile Lys Asp Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg 
             260                265                270
Gln Ser Gln Glu Lys Ile Asp Asp Ile Leu Gln Thr Leu Leu Asp Ala 
         275                280                285
Thr Tyr Lys Asp Gly Arg Pro Leu Thr Asp Asp Glu Val Ala Gly Met 
     290                295                300
Leu Ile Gly Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser 
 305                310                315                320
Ala Trp Met Gly Phe Phe Leu Ala Arg Asp Lys Thr Leu Gln Lys Lys 
                 325                330                335
Cys Tyr Leu Glu Gln Lys Thr Val Cys Gly Glu Asn Leu Pro Pro Leu 
             340                345                350
Thr Tyr Asp Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys 
         355                360                365
Glu Thr Leu Arg Leu Arg Pro Pro Ile Met Ile Met Met Arg Met Ala 
     370                375                380
Arg Thr Pro Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln 
 385                390                395                400
Val Cys Val Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val 
                 405                410                415
Glu Arg Leu Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala 
             420                425                430
Ser Gly Glu Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg 
         435                440                445
Cys Ile Gly Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser 
     450                455                460
Thr Met Leu Arg Leu Tyr Glu Phe Asp Leu Ile Asp Gly Tyr Phe Pro 
 465                470                475                480
Thr Val Asn Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile 
                 485                490                495
Arg Tyr Lys Arg Arg Ser Lys 
             500



<210> 6460
<211> 366
<212> DNA
<213> Rattus norvegicus
<308> AA997806
<400> 6460

ttttttttt  tttttttcc  atacctatt  ctttaatta  ttttcatga  caatcctat  60
taggtatta  ccctatttt  ttttctgaa  cagggttag  aaagccaga  tgctcgcga  120
ctaatatgt  acaatacaa  tgagccaag  tgaggggta  gctacacaa  aaggaagta  180
ttatttgct  tcccctccc  cctactttc  atcccgagt  tgtcaagat  actcagatc  240
tgatttttc  ctaacttgt  aaaatatgt  atcttgagt  tgggctgct  cagaattct  300
ggtctttgt  ccagcttgg  tgcaggtgt  gttcctatg  gcttcctgc  cttgctgtt  360
actgca  366



<210> 6461
<211> 511
<212> PRT
<213> Rattus norvegicus
<308> P15129
<400> 6461

Met Val Leu Asn Phe Leu Ser Pro Ser Leu Ser Arg Leu Gly Leu Trp 
  1               5                  10                  15
Ala Ser Val Val Ile Leu Met Val Ile Val Leu Lys Leu Phe Ser Leu 
             20                  25                  30
Leu Leu Arg Arg Gln Lys Leu Ala Arg Ala Met Asp Ser Phe Pro Gly 
         35                  40                  45
Pro Pro Thr His Trp Leu Phe Gly His Ala Leu Glu Ile Gln Lys Leu 
     50                  55                  60
Gly Ser Leu Asp Lys Val Val Ser Trp Ala Gln Gln Phe Pro His Ala 
 65                  70                  75                  80
His Pro Leu Trp Phe Gly Gln Phe Val Gly Phe Leu Asn Ile Tyr Glu 
                 85                  90                  95
Pro Asp Tyr Ala Lys Ala Val Tyr Ser Arg Gly Asp Pro Lys Ala Ala 
             100                105                110
Asp Val Tyr Asp Phe Phe Leu Gln Trp Ile Gly Lys Gly Leu Leu Val 
         115                120                125
Leu Asp Gly Pro Lys Trp Phe Gln His Arg Lys Leu Leu Thr Pro Gly 
     130                135                140
Phe His Tyr Asp Val Leu Lys Pro Tyr Val Ala Ile Phe Ala Glu Ser 
 145                150                155                160
Thr Arg Met Met Leu Asp Lys Trp Glu Lys Lys Ala Ser Glu Asn Lys 
                 165                170                175
Ser Phe Asp Ile Phe Cys Asp Val Gly His Met Ala Leu Asp Thr Leu 
             180                185                190
Met Lys Cys Thr Phe Gly Lys Gly Asp Ser Gly Leu Gly His Arg Asp 
         195                200                205
Asn Ser Tyr Tyr Leu Ala Val Ser Asp Leu Thr Leu Leu Met Gln Gln 
     210                215                220
Arg Ile Asp Ser Phe Gln Tyr His Asn Asp Phe Ile Tyr Trp Leu Thr 
 225                230                235                240
Pro His Gly Arg Arg Phe Leu Arg Ala Cys Lys Ile Ala His Asp His 
                 245                250                255
Thr Asp Glu Val Ile Arg Gln Arg Lys Ala Ala Leu Gln Asp Glu Lys 
             260                265                270
Glu Arg Lys Lys Ile Gln Gln Arg Arg His Leu Asp Phe Leu Asp Ile 
         275                280                285
Leu Leu Gly Val Arg Asp Glu Ser Gly Ile Lys Leu Ser Asp Ala Glu 
     290                295                300
Leu Arg Ala Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr 
 305                310                315                320
Thr Ser Gly Ile Ser Trp Phe Leu Tyr Cys Met Ala Leu Tyr Pro Glu 
                 325                330                335
His Gln Gln Leu Cys Arg Glu Glu Val Arg Gly Ile Leu Gly Asp Gln 
             340                345                350
Asp Ser Phe Gln Trp Asp Asp Leu Ala Lys Met Thr Tyr Leu Thr Met 
         355                360                365
Cys Met Lys Glu Cys Phe Arg Leu Tyr Pro Pro Val Pro Gln Val Tyr 
     370                375                380
Arg Gln Leu Asn Lys Pro Val Thr Phe Val Asp Gly Arg Ser Leu Pro 
 385                390                395                400
Ala Gly Ser Leu Ile Ser Leu His Ile Tyr Ala Leu His Arg Asn Ser 
                 405                410                415
Thr Val Trp Pro Asp Pro Glu Val Phe Asp Pro Leu Arg Phe Ser Pro 
             420                425                430
Glu Asn Ala Ala Gly Arg His Pro Phe Ala Phe Met Pro Phe Ser Ala 
         435                440                445
Gly Pro Arg Asn Cys Ile Gly Gln Gln Phe Ala Met Asn Glu Met Lys 
     450                455                460
Val Val Thr Ala Leu Cys Leu Leu Arg Phe Glu Phe Ser Leu Asp Pro 
 465                470                475                480
Ser Lys Met Pro Ile Lys Val Pro Gln Leu Ile Leu Arg Ser Lys Asn 
                 485                490                495
Gly Ile His Leu Tyr Leu Lys Pro Leu Ala Ser Arg Ser Gly Lys 
             500                505                510



<210> 6462
<211> 2130
<212> DNA
<213> Homo sapiens
<308> X16699
<400> 6462

atggtgccc  gcttcctct  cctgagctt  tcctccttg  gcctgtggg  ttctgggct  60
atcttggtc  taggctttc  caagctcat  cacctgctg  tgcggaggc  gacgttggc  120
aaggctatg  acaaattcc  agggcctcc  acccactgg  tttttggac  tgccctcga  180
atccaggag  cggggagcc  ggacaaagt  gtgtcctgg  cccaccagt  cccgtatgc  240
cacccactc  ggttcggac  gttcattgg  ttcctgaac  tctatgagc  tgactatgc  300
aaagctgtg  acagccgtg  ggaccctaa  gcccctgat  tgtatgact  cttcctcca  360
tggattggg  gaggcctgc  ggttcttga  gggcccaag  ggttgcagc  ccgcaagct  420
ctcacacct  gctttcatt  tgatgtgct  aagccctat  tggccgtgt  cactgagtc  480
acacgtatc  tgctggaca  gtgggaaga  aaagctcgg  agggtaagt  ctttgacat  540
ttctgcgat  tgggtcaca  ggcgctgaa  acactcatg  agtgcacct  tggaagagg  600
gacaccggc  tgggccaca  ggacagcag  tactacctt  cagtcagcg  tctcactct  660
ttgatgcag  agcgccttg  gtccttcca  taccataat  acttcatct  ctggctcac  720
ccacatggc  gccgcttcc  gcgggcctg  caggtggcc  atgaccata  agaccaggt  780
atcagggag  ggaaggcag  cctgcagga  gagaaggtg  ggaagaaga  ccagaaccg  840
aggcacctg  acttcctgg  cattctcct  ggtgcccgg  atgaagatg  catcaaact  900
tcagatgca  acctccggg  tgaagtgga  acattcatg  ttgaaggcc  tgacaccac  960
accagtggt  tctcctggt  tctctactg  atggccctg  accctgagc  ccagcatcg  1020
tgtagagag  aggtccgcg  gatcctagg  gaccaggac  tcttccagt  ggatgatct  1080
ggcaaaatg  cttatctga  catgtgcat  aaggagagc  tccgcctct  cccacctgt  1140
ccccaggtg  accgccagc  cagcaagcc  gtcaccttt  tggatggcc  gtctctacc  1200
gcaggaagc  tgatctcta  gcatatcta  gccctccat  ggaacagtg  tgtatggcc  1260
gaccctgag  tctttgact  tctgcgctt  tccactgag  atgcatcca  acgccatcc  1320
tttgccttt  tgcccttct  tgctgggcc  aggaactgc  ttgggcagc  gtttgccat  1380
agtgagatg  aggtggtca  agccatgtg  ttgctccgc  ttgagttct  tctggaccc  1440
tcacggctg  ccatcaaga  gccccagct  gtcctgcgc  ccaagaatg  ctttcacct  1500
cacctgaag  cactgggcc  tgggtctgg  aagtagctc  gatgagaat  gggtcccag  1560
tggctcagg  tgtgacctc  ctgggcacc  ccctcccca  gctgggtgt  gaggagttg  1620
ggccccctg  cgttcagag  ttgtagttt  gaagggaag  aggcattac  atagacgac  1680
cctagagga  agtgctatg  aaaaatgtg  gtctataat  tttatcatg  atgtattct  1740
gagctcatt  atttattca  caaacattt  gtgagcacc  atttcgttc  agaaacttc  1800
tttatctcc  ataattggc  aacttaaaa  tgcagcaga  acttacatt  caaccttag  1860
gactcatag  gagcacaag  aaagttttg  cctgagatt  atggttatg  ctgggtacc  1920
ccaaataga  gaatggctt  ggggagtgc  ccttcacga  tgtgtttct  tgttgaact  1980
tgtgtgtgt  tgtttagaa  ataacagac  taagaaaaa  ttacctaaa  gaagactgt  2040
caaaataat  aataattct  aagcagact  tcttgtaac  atcactgaa  tcaagaaat  2100
tggaatatg  tatcactga  ggtcttctgc  2130



<210> 6463
<211> 511
<212> PRT
<213> Homo sapiens
<308> P13584
<400> 6463

Met Val Pro Ser Phe Leu Ser Leu Ser Phe Ser Ser Leu Gly Leu Trp 
  1               5                  10                  15
Ala Ser Gly Leu Ile Leu Val Leu Gly Phe Leu Lys Leu Ile His Leu 
             20                  25                  30
Leu Leu Arg Arg Arg Thr Leu Ala Lys Ala Met Asp Lys Phe Pro Gly 
         35                  40                  45
Pro Pro Thr His Trp Leu Phe Gly His Ala Leu Glu Ile Gln Glu Thr 
     50                  55                  60
Gly Ser Leu Asp Lys Val Val Ser Trp Ala His Gln Phe Pro Tyr Ala 
 65                  70                  75                  80
His Pro Leu Trp Phe Gly Gln Phe Ile Gly Phe Leu Asn Ile Tyr Glu 
                 85                  90                  95
Pro Asp Tyr Ala Lys Ala Val Tyr Ser Arg Gly Asp Pro Lys Ala Pro 
             100                105                110
Asp Val Tyr Asp Phe Phe Leu Gln Trp Ile Gly Arg Gly Leu Leu Val 
         115                120                125
Leu Glu Gly Pro Lys Trp Leu Gln His Arg Lys Leu Leu Thr Pro Gly 
     130                135                140
Phe His Tyr Asp Val Leu Lys Pro Tyr Val Ala Val Phe Thr Glu Ser 
 145                150                155                160
Thr Arg Ile Met Leu Asp Lys Trp Glu Glu Lys Ala Arg Glu Gly Lys 
                 165                170                175
Ser Phe Asp Ile Phe Cys Asp Val Gly His Met Ala Leu Asn Thr Leu 
             180                185                190
Met Lys Cys Thr Phe Gly Arg Gly Asp Thr Gly Leu Gly His Arg Asp 
         195                200                205
Ser Ser Tyr Tyr Leu Ala Val Ser Asp Leu Thr Leu Leu Met Gln Gln 
     210                215                220
Arg Leu Val Ser Phe Gln Tyr His Asn Asp Phe Ile Tyr Trp Leu Thr 
 225                230                235                240
Pro His Gly Arg Arg Phe Leu Arg Ala Cys Gln Val Ala His Asp His 
                 245                250                255
Thr Asp Gln Val Ile Arg Glu Arg Lys Ala Ala Leu Gln Asp Glu Lys 
             260                265                270
Val Arg Lys Lys Ile Gln Asn Arg Arg His Leu Asp Phe Leu Asp Ile 
         275                280                285
Leu Leu Gly Ala Arg Asp Glu Asp Asp Ile Lys Leu Ser Asp Ala Asp 
     290                295                300
Leu Arg Ala Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr 
 305                310                315                320
Thr Ser Gly Ile Ser Trp Phe Leu Tyr Cys Met Ala Leu Tyr Pro Glu 
                 325                330                335
His Gln His Arg Cys Arg Glu Glu Val Arg Glu Ile Leu Gly Asp Gln 
             340                345                350
Asp Phe Phe Gln Trp Asp Asp Leu Gly Lys Met Thr Tyr Leu Thr Met 
         355                360                365
Cys Ile Lys Glu Ser Phe Arg Leu Tyr Pro Pro Val Pro Gln Val Tyr 
     370                375                380
Arg Gln Leu Ser Lys Pro Val Thr Phe Val Asp Gly Arg Ser Leu Pro 
 385                390                395                400
Ala Gly Ser Leu Ile Ser Met His Ile Tyr Ala Leu His Arg Asn Ser 
                 405                410                415
Ala Val Trp Pro Asp Pro Glu Val Phe Asp Ser Leu Arg Phe Ser Thr 
             420                425                430
Glu Asn Ala Ser Lys Arg His Pro Phe Ala Phe Met Pro Phe Ser Ala 
         435                440                445
Gly Pro Arg Asn Cys Ile Gly Gln Gln Phe Ala Met Ser Glu Met Lys 
     450                455                460
Val Val Thr Ala Met Cys Leu Leu Arg Phe Glu Phe Ser Leu Asp Pro 
 465                470                475                480
Ser Arg Leu Pro Ile Lys Met Pro Gln Leu Val Leu Arg Ser Lys Asn 
                 485                490                495
Gly Phe His Leu His Leu Lys Pro Leu Gly Pro Gly Ser Gly Lys 
             500                505                510



<210> 6464
<211> 524
<212> DNA
<213> Rattus norvegicus
<308> AA997886
<400> 6464

cggccgcca  acttttttt  tcagagtaa  accatttat  gcacactag  accccagca  60
gcacagtga  tgagatgct  tgcctcccc  tagcggggt  aagcacaga  ctggtaggg  120
cgcggggtg  tcagagcac  aaagatgcc  tagtcgctg  gccggggct  tccagtggg  180
acggagaag  tgaagcgct  caggaggca  gtgaagaag  ggaagagct  catgcgggc  240
aggggctcc  ccaggcatg  tctgcggcc  gctgagaat  gcatgaagg  ctcatgctt  300
acaaagttg  cctgggcat  caggaagtg  tcagggtgg  agcggaggg  cttctccca  360
acggtctca  ccttcagca  tgaggacag  ttggtgatg  gggttgtcc  cttagggat  420
aggaagccc  gcacttcaa  gtcacgaga  gtcttgtga  gcacaccaa  agggagaat  480
tctgcaaag  gctgcacct  atggatgac  gcattggtg  acgg  524



<210> 6465
<211> 500
<212> PRT
<213> Rattus norvegicus
<308> Q64680
<400> 6465

Met Arg Met Pro Thr Gly Ser Glu Leu Trp Pro Ile Ala Ile Phe Thr 
  1               5                  10                  15
Ile Ile Phe Leu Leu Leu Val Asp Leu Met His Arg Arg Gln Arg Trp 
             20                  25                  30
Thr Ser Arg Tyr Pro Pro Gly Pro Val Pro Trp Pro Val Leu Gly Asn 
         35                  40                  45
Leu Leu Gln Ile Asp Phe Gln Asn Met Pro Ala Gly Phe Gln Lys Leu 
     50                  55                  60
Arg Cys Arg Phe Gly Asp Leu Phe Ser Leu Gln Leu Ala Phe Glu Ser 
 65                  70                  75                  80
Val Val Val Leu Asn Gly Leu Pro Ala Leu Arg Glu Ala Leu Val Lys 
                 85                  90                  95
Tyr Ser Glu Asp Thr Ala Asp Arg Pro Pro Leu His Phe Asn Asp Gln 
             100                105                110
Ser Gly Phe Gly Pro Arg Ser Gln Gly Val Val Leu Ala Arg Tyr Gly 
         115                120                125
Pro Ala Trp Arg Gln Gln Arg Arg Phe Ser Val Ser Thr Phe Arg His 
     130                135                140
Phe Gly Leu Gly Lys Lys Ser Leu Glu Gln Trp Val Thr Glu Glu Ala 
 145                150                155                160
Arg Cys Leu Cys Ala Ala Phe Ala Asp His Ser Gly Phe Pro Phe Ser 
                 165                170                175
Pro Asn Thr Leu Leu Asp Lys Ala Val Cys Asn Val Ile Ala Ser Leu 
             180                185                190
Leu Phe Ala Cys Arg Phe Glu Tyr Asn Asp Pro Arg Phe Ile Arg Leu 
         195                200                205
Leu Asp Leu Leu Lys Asp Thr Leu Glu Glu Glu Ser Gly Phe Leu Pro 
     210                215                220
Met Leu Leu Asn Val Phe Pro Met Leu Leu His Ile Pro Gly Leu Leu 
 225                230                235                240
Gly Lys Val Phe Ser Gly Lys Lys Ala Phe Val Ala Met Leu Asp Glu 
                 245                250                255
Leu Leu Thr Glu His Lys Val Thr Trp Asp Pro Ala Gln Pro Pro Arg 
             260                265                270
Asp Leu Thr Asp Ala Phe Leu Ala Glu Val Glu Lys Ala Lys Gly Asn 
         275                280                285
Pro Glu Ser Ser Phe Asn Asp Glu Asn Leu Arg Val Val Val Ala Asp 
     290                295                300
Leu Phe Met Ala Gly Met Val Thr Thr Ser Thr Thr Leu Thr Trp Ala 
 305                310                315                320
Leu Leu Phe Met Ile Leu Arg Pro Asp Val Gln Cys Arg Val Gln Gln 
                 325                330                335
Glu Ile Asp Glu Val Ile Gly Gln Val Arg Arg Pro Glu Met Ala Asp 
             340                345                350
Gln Ala Arg Met Pro Phe Thr Asn Ala Val Ile His Glu Val Gln Arg 
         355                360                365
Phe Ala Asp Ile Leu Pro Leu Gly Val Pro His Lys Thr Ser Arg Asp 
     370                375                380
Ile Glu Val Gln Gly Phe Leu Ile Pro Lys Gly Thr Thr Leu Ile Ile 
 385                390                395                400
Asn Leu Ser Ser Val Leu Lys Asp Glu Thr Val Trp Glu Lys Pro Leu 
                 405                410                415
Arg Phe His Pro Glu His Phe Leu Asp Ala Gln Gly Asn Phe Val Lys 
             420                425                430
His Glu Ala Phe Met Pro Phe Ser Ala Gly Arg Arg Ala Cys Leu Gly 
         435                440                445
Glu Pro Leu Ala Arg Met Glu Leu Phe Leu Phe Phe Thr Cys Leu Leu 
     450                455                460
Gln Arg Phe Ser Phe Ser Val Pro Ala Gly Gln Pro Arg Pro Ser Asn 
 465                470                475                480
Tyr Gly Val Phe Gly Ala Leu Thr Thr Pro Arg Pro Tyr Gln Leu Cys 
                 485                490                495
Ala Ser Pro Arg 
             500



<210> 6466
<211> 9432
<212> DNA
<213> Homo sapiens
<308> M33388
<400> 6466

gaattcaag  ccagcctgg  caacttgga  gaacccggt  tctacaaaa  atacaaaat  60
agctgggat  gggtgcggt  gctcatgcc  ataatccca  cactttggg  gcctgaggt  120
ggtggatca  ctgaagtca  gagttcaag  ctagcctgg  caacatggt  aaaccctat  180
tctactgaa  atacaaaaa  ctagacgtg  tggcacaca  ctgtaatcc  agctactta  240
gaggctgag  caggagaat  gcttgaagc  tagaggtga  ggttgtagt  agccgagat  300
gcatcattg  acaatggag  ggagccacc  gcctgggca  caagaggaa  tctccgtct  360
caaaaaaaa  aaaaaaaaa  aaagaatta  gctgggtgg  gcctgtagt  ccagctact  420
gggaggcag  gggtccact  gatgtcgag  ctgcagtga  ccatgatcc  gccactgca  480
tccggcctg  gcaacagag  gagaccctg  ctaaagaaa  aaaaaataa  gcaacatat  540
ctgaacaaa  gatcctcca  aacgttccc  ccagatttc  aatcagaaa  atggaggcc  600
gaaagcagt  gaggaggac  accctcagg  agcccggga  gatgttgtc  caggctggg  660
caagggcct  ccggctacc  actgggagc  ctgggaaca  ccctgttgc  aacaagaag  720
catagcccg  ccagagccc  ggaatgtgg  ctgggctgg  agcagcctc  ggacaggag  780
ggtcccatc  aggaaacct  cggcatggc  gggaagtgg  gtacttggt  ccgggtctg  840
atgtgtgtg  gactggtgt  tgtgagaga  aatgtgtgc  ctaagtgtc  gtgtgagtc  900
gtgtatgtg  gaatattgt  tttgtgtgg  tgattttct  cgtgtgtaa  cgtgtccct  960
caagtgtga  caagtggac  agtgtctgg  agtggacaa  agatctgtg  accatcagg  1020
gtgtgcata  cgtctgtgc  tgtcaagag  gcaaggtga  gtgaaggga  caggcccat  1080
atgccactc  tcatcagga  ctctaaggc  ccaggtaag  gccagtgac  gataagggt  1140
ctgaaggtc  ctctggagt  ggcaggtgg  ggtagggaa  gggcaaggc  atgttctgg  1200
ggaggggtt  tgactacat  agggtgtat  agcctagct  ggaggtgga  ggccgggtc  1260
actgaaacc  tggttatcc  agaaggctt  gcaggcttc  ggagcttgg  gtggggaga  1320
ggggtgact  ctccgacca  gcccctcca  cggcctacc  tgggtaagg  cctggagca  1380
gaagcaggg  caagaacct  tggagcagc  catacccgc  ctggcctga  tctgccact  1440
gcagcacag  caacacagc  ggttcactc  cagcagagg  caaaggcca  catcagctc  1500
ctttataag  gaagggtca  gcgctcggt  tgctgagag  gtcctgcct  gtcctctgt  1560
cctggtggg  tgggggtgc  aggtgtgtc  agaggagcc  atttggtag  gaggcaggt  1620
tggggctag  agcactggt  cccctggcc  tgatagtgg  catcttcct  ctcctggtg  1680
acctgatgc  ccggcgcca  cgctgggct  cacgctacc  accaggccc  ctgccactg  1740
ccgggctgg  caacctgct  catgtggac  tccagaaca  accatactg  ttcgaccag  1800
tgagggagg  ggtcctgga  ggcggcaga  gtgctgagg  tcccctacc  gaagcaaac  1860
tggatggtg  gtgaaacca  aggctggac  agaagccag  ctgagaagg  gaagcaggt  1920
tgggggacg  cctggagaa  ggcatttat  catggcatg  aggactgga  tttccaaag  1980
ccaaggaag  gtagggcaa  ggcctggag  tggagctgg  cttggcagt  ggcatgcaa  2040
cccattggg  aacatatgt  atggagtac  aagtccctt  tgctgacac  agaaggaaa  2100
gccttggga  tggaagatg  gttagtcct  agtgccgtt  aaatcacga  atcgaggat  2160
aagggggtg  agtgacccg  ttcaaacct  ttgcactgt  ggtcctcgg  cctcactgc  2220
tcaccggca  ggaccatca  ctgggaatg  gatgctaac  ggggcctct  ggcaatttt  2280
gtgactctt  caaggtcat  cctgggtga  gcatccaaa  tgagttcct  catcacaga  2340
ggtgtgacc  ccacccccg  cccacgatc  ggaggctgg  tctcctcct  ccacctgct  2400
actcctggt  gccccgggg  tcgtccaag  ttcaaatag  actaggacc  gtagtctgg  2460
gtgatcctg  cttgacaag  ggccctgac  ctccctctg  agttgcggc  ccgcttcgg  2520
gacgtgttc  gcctgcagc  ggcctggac  ccggtggtc  tgctcaatg  gctggcggc  2580
gtgcgcgag  cgctggtga  ccacggcga  gacaccgcc  accgcccgc  tgtgcccat  2640
acccagatc  tgggtttcg  gccgcgttc  caaggcaag  agcggtggg  acagagaca  2700
atttccgtg  gacccgggt  ggtgatgac  gtagtccga  ctgggcaga  agggcgcgg  2760
gtcgtggac  tgaaacagg  cagcgagtg  ggacagcgg  ccaagaaac  acctgcact  2820
gggaggtgt  agcatgggg  cgagggcgg  gcttgtgac  agtgggcgg  gccactgcc  2880
agacctggc  ggagcccaa  gggtgagcg  ggcgcattt  ccagctgga  tccggtgtc  2940
aagtggggg  ggggaccgc  cctgtgctg  aagctcagt  tgggtggcg  ggggcccgc  3000
gggtcttcc  tgagtgcaa  ggcggtcag  gtgggcaga  acgaggtgg  gcaaagcct  3060
ccccagcca  gggagcaag  tggatgcac  aagagtggg  cctgtgacc  gctggacag  3120
gccagggac  gcgggagac  agggggagc  tagggttgg  gtgggtggt  gatggtggg  3180
ctaatgcct  catggccac  cgcacgtgc  cgtcccacc  ccaggggtg  tcctggcgc  3240
ctatgggcc  gcgtggcgc  agcagaggc  cttctccgt  tccaccttg  gcaacttgg  3300
cctgggcaa  aagtcgctg  agcagtggg  gaccgagga  gccgcctgc  tttgtgccg  3360
cttcgccaa  cactccggt  ggtgatggg  agaagggca  aaagcggga  ctgggaagg  3420
gggggacgg  gaaggcgac  ccttacccg  atctcccac  cccaggacg  ccctttcgc  3480
ccaacggtc  cttggacaa  gccgtgagc  acgtgatcg  ctccctcac  tgcgggcgc  3540
gcttcgagt  cgacgaccc  cgcttcctc  ggctgctgg  cctagctca  gagggactg  3600
aggaggagt  gggctttct  cgcgaggtg  ggagcgaga  accgaggag  ctctgcagg  3660
cgagctccc  agaggtgcc  gggctggac  ggggcctcg  aagagcagg  tttgcatag  3720
tgggtttgg  aaaggacat  ccaggagac  ccactgtaa  aagggcctg  aggaggagg  3780
gacatctca  acatggtcg  gggagaggt  tgcccgggt  agggggcac  aggagaggc  3840
aaggactct  tacctccta  ccacgtcag  gatttcgat  ttaggtttc  cctctgggc  3900
aggagagag  gtggaggct  gcacttggg  agggacttg  tgaggtcag  ggtaaggac  3960
ggcaggccc  gggtctacc  ggagatggc  ggggcctga  acttgtcca  gtgaacgca  4020
agcacagga  ggattgaga  cccgttctg  ctggtgtag  tgctgaatg  tgtccccgt  4080
ctcctgcat  tcccagcgc  ggctggcaa  gtcctacgc  tccaaaagg  tttcctgac  4140
cagctggat  agctgctaa  tgagcacag  atgacctgg  acccagccc  gcccccccg  4200
gacctgact  aggccttcc  ggcagagat  gagaaggtg  gagtggctg  cacggtggg  4260
ggcaagggt  gtgggttga  cgtcccagg  ggaatgagg  gaggctggg  aaaaggttg  4320
accagtgca  cacccggcg  gccgcatct  ggctgacag  tgcagaatt  gaggtcatt  4380
gggggctac  ccgttctgt  ccgagtatg  tctcggccc  gctcaggcc  aggggaacc  4440
tgagagcag  ttcaatgat  agaacctgc  catagtggt  gctgacctg  tctctgccg  4500
gatggtgac  acctcgacc  cgctggcct  gggcctcct  ctcatgatc  tacatccgg  4560
tgtgcagcg  gagcccatc  gggaaacag  gcaggggcc  agggaggaa  ggtacaggc  4620
ggggcccat  aactttgct  ggacacccg  ggctccaag  acaggcttg  ccaggatcc  4680
gtaagcctg  cctcctcca  cataggagg  aagaaggag  gtcagggcc  gaccccctg  4740
gtgctgacc  attgtgggg  cgcatgtct  tccaggccg  gtccaacag  agatcgacg  4800
cgtgatagg  caggtgcgg  gaccagaga  gggtgacca  gctcacatg  cctacacca  4860
tgccgtgat  catgaggtg  agcgctttg  ggacatcgt  cccctgggt  tgacccata  4920
gacatcccg  gacatcgaa  tacagggct  ccgcatccc  aaggtaggc  tggcgccct  4980
ctcacccca  ctcagcacc  gcacctggt  atagcccca  catggctac  gccaggtgg  5040
cccactcta  gaaccctgg  cacctagtc  tcaatgcca  cacactgac  gtccccact  5100
gggtggggg  tccagagta  aggcagggc  ggcctgtcc  tccagagcc  ccgtctagt  5160
gggagacaa  ccaggacct  ccagaatgt  ggaggaccc  acgcctgca  ggagagggg  5220
cagtgtggg  gcctctgag  ggtgtgact  cgccctgct  tggggtcgg  gagggtact  5280
tggagcttc  cgggcgcag  actagttga  agagtccag  tgtgtgcca  gcagtgtgt  5340
tcccccgtg  gtttggtgg  aggggtccc  gcatcctag  gtccagtcc  cactctcac  5400
ctgcatctc  tgcccaggg  acgacactc  tcaccaacc  gtcatcggt  ctgaaggat  5460
aggccgtct  ggagaagcc  ttccgcttc  accccgaac  cttcctgga  gcccagggc  5520
actttgtga  gccggaggc  ttcctgcct  tctcagcag  tgcctgtgg  gagcccggc  5580
ccctgtccc  ttccgtgga  tcttgcagg  gtatcaccc  ggagccagg  tcactgacg  5640
ccctcccct  cccacaggc  gccgtgcat  cctcgggga  cccctggcc  gcatggagc  5700
cttcctctt  ttcacctcc  tgctgcagc  cttcagctt  tcggtgccc  ctggacagc  5760
ccggcccag  caccatggt  tctttgctt  cctggtgag  ccatccccc  atgagcttt  5820
tgctgtgcc  cgctagaat  gggtaccta  tccccagcc  gctccctag  cagaggctc  5880
aatgtacaa  aaagcaatg  ggtagttcc  actcgggtc  cctgctcac  ccctcgttg  5940
gatcatcct  ctcagggca  ccccacccc  gcctcattc  tgcttaccc  accgcctgg  6000
cgcatttga  acaggggta  gttgaggct  agcagatgt  agttaccct  gcccataat  6060
ccatgtccc  cactgaccc  actctgact  cccagattg  tgacaagga  tacattgtc  6120
tggcatgtg  ggaaggggc  agaatgggc  gactagagg  gtcagtcag  cctggatgt  6180
gtggagagg  caggactca  cctggaggc  catatttca  gcctaactc  gcccacccc  6240
catcaggga  agcagtcct  ccagcacca  cacaacagt  acctccctt  atatatgac  6300
ccccaaaac  gaagacaaa  catggcgtc  gggagctat  tgccagggc  acctacctc  6360
cagggctca  tcggcaggt  ccagaacgt  ccctgggaa  gccccatgg  agcccagga  6420
tgagccacc  ccctcagcc  cgtcacctc  ccacaggac  ggctacctc  ctgggccct  6480
agggatgct  ctgtacaga  ccctgacca  tgacgagtt  gcactcagg  ccaggctgg  6540
gctggagga  gacacttgt  tggctccaa  cctaggtac  atcctccca  tagggatca  6600
gcagggccc  caggcctgc  ctagggaca  gagtcaacc  tggacccat  aggcactgg  6660
gcgggcaga  aaggaggag  tggcatggg  agctgagag  cagagaccc  gaccctagt  6720
cttgctctg  cattacccc  tgtgacccc  ggcccaccc  tccccaccc  tccccaccc  6780
gggcttctg  ttccttctg  caacgagaa  gctgcttca  ctgccccga  tcctgtctt  6840
ctgctctgc  ttctggggc  gtggccctt  ctggcctgg  gccccaacc  agggcaggg  6900
ctgctgtcc  ccacgtctg  cctcaccga  ataatgggc  gggctgggc  cacaggcag  6960
gcccaagag  ttctaatga  catatgatt  cctgagtcc  gggcagacc  tcttaggga  7020
cagcctggg  cagagaacc  cagacactc  gaggagcca  cctgaggcc  cttttgcca  7080
aggacccta  agcctccct  gcagcagtt  cgccagcat  tctgtaaat  ccctcatgc  7140
agggtgcgg  ccggctgtc  gcacgagag  gacgttggt  tgtcccctg  caccgagtc  7200
gtcagaagg  tggccaggg  ccccttggg  ccctccaga  acaatccac  gtggtcaca  7260
ggctcggtg  caggaagtg  tgttcctgc  gctgtgggg  cagggagtg  ggatgaagc  7320
aggctgggt  tgtctgaag  cggaggccc  gaaaggtgg  agcctggcc  atagcagca  7380
caactcttg  atttattgg  aagattttc  tcacggttc  gagtcttgg  ggtgttaga  7440
gctcagaac  agtccagcc  gagctctgt  atgggcacg  agacccggt  ccagggcct  7500
tgctctttg  tgtcctcag  ggcctctgc  aagtagaaa  aggcagcct  gtgagtccc  7560
tcctgggag  aaccaaccc  ccctctgag  tgccccggg  ccaggtcag  tgtggtgaa  7620
ggtagggat  cagccagct  agggagtgg  ccagagttc  tgcccaccc  aggaggctc  7680
caggaaggt  aaggcacct  actcctggg  tgcttccct  ccctcccct  cccaggtca  7740
gaaggtggg  aagggctgg  gtgtctgtg  ccctggcag  cactgagaa  cagggtgga  7800
gcagccccc  gcagcacgc  gggtcagtg  tcttaccag  tggatacgc  gcaacttcc  7860
tttgaacct  tttattttc  tggcaggaa  aagagggat  cagcagtga  atcaggcag  7920
ttctgtgtt  cacagacag  gaaacaggc  ctgtccaca  aaagtcggt  gggccagga  7980
gaggcccag  ctgttcaca  atggctgct  cctctcagc  ctgcacaga  gtcctcgct  8040
ccctgggat  gcagcttgg  ctgctggtc  tggggttga  ccagcctcc  gcactgcct  8100
cctgccctg  tgcctccca  tctgcagtg  tccatggct  ctcagttgg  cccacgctg  8160
agacgttca  tcgaagccc  gggctgtcc  tacctccca  tctggggta  ctgccacct  8220
ctgctcagc  ggaatgggg  taggtgctt  ctcccctgg  gacttcacc  gctctccct  8280
ctgggataa  acggcagcc  cctccttgg  ggcagcagc  ttcagtcct  caggtctcc  8340
gggggtcgt  acctgcagg  ggaataaga  ggcagactg  gcagaaagg  cttcagagc  8400
cctcatcct  ctgttctca  actggggtg  cacagtcct  ggaagttct  ccttttcag  8460
tgagctgtg  taaccttgt  agtttcctg  agggggcct  ccactaccc  tgggactcc  8520
tgccgtgtg  ctgggtcta  ctgagctct  aaaggagag  gccccagcc  tgggccttc  8580
aggggaagc  ttacctcag  ggttggctt  ttcctactc  tgactttgc  tctctgcag  8640
gggaggtgg  aggggtgac  caaccctga  acccacact  tgagtgatg  gtagtcctg  8700
cccgactgg  ccatccttt  caggtgcag  cccccttac  gtgtctgcc  agggtgcca  8760
cacagccgc  ccactccag  ggaagagga  tgccagccc  taccacctg  gtgggcaca  8820
tgtagcatt  attcattag  ccccacact  gcctgacca  ctcccctgt  ggctgcatg  8880
caaggagag  gaacaggct  aggtgagag  tactgtcaa  acctaaacc  aaaaaatct  8940
taattgggc  gggcagggt  gctcacgcc  gtaatccca  cactttggg  ggccgagat  9000
ggtggatca  ctgaggtca  atgttcgag  ccagcctgg  caacatggt  aaaccccgt  9060
tctactaaa  atacaaaaa  ttagctggg  gtggtggtg  gtgcctgta  tcccagcta  9120
tcaggaggc  gaggcagga  aattgcttg  acctgggag  cagaggctg  agtgagccg  9180
gatcgcatc  ttgcactcc  gcctggtca  caagagtga  actgtctta  aaaaaaaat  9240
tataattga  atctttaga  agataaaac  ttgcattca  gaaataaga  taggagggt  9300
taaaataaa  atgttcaaa  acccaccac  actaattct  gacaaaaat  tagtctggg  9360
gccttagct  atgcctgta  tcccagcat  ttgggaggc  aaggcagga  gattgtttg  9420
gcctaggaa  tc  9432



<210> 6467
<211> 497
<212> PRT
<213> Homo sapiens
<308> AAA53500
<400> 6467

Met Gly Leu Glu Ala Leu Val Pro Leu Ala Val Ile Val Ala Ile Phe 
  1               5                  10                  15
Leu Leu Leu Val Asp Leu Met His Arg Arg Gln Arg Trp Ala Ala Arg 
             20                  25                  30
Tyr Pro Pro Gly Pro Leu Pro Leu Pro Gly Leu Gly Asn Leu Leu His 
         35                  40                  45
Val Asp Phe Gln Asn Thr Pro Tyr Cys Phe Asp Gln Leu Arg Arg Arg 
     50                  55                  60
Phe Gly Asp Val Phe Ser Leu Gln Leu Ala Trp Thr Pro Val Val Val 
 65                  70                  75                  80
Leu Asn Gly Leu Ala Ala Val Arg Glu Ala Leu Val Thr His Gly Glu 
                 85                  90                  95
Asp Thr Ala Asp Arg Pro Pro Val Pro Ile Thr Gln Ile Leu Gly Phe 
             100                105                110
Gly Pro Arg Ser Gln Gly Val Phe Leu Ala Arg Tyr Gly Pro Ala Trp 
         115                120                125
Arg Glu Gln Arg Arg Phe Ser Val Ser Thr Leu Arg Asn Leu Gly Leu 
     130                135                140
Gly Lys Lys Ser Leu Glu Gln Trp Val Thr Glu Glu Ala Ala Cys Leu 
 145                150                155                160
Cys Ala Ala Phe Ala Asn His Ser Gly Arg Pro Phe Arg Pro Asn Gly 
                 165                170                175
Leu Leu Asp Lys Ala Val Ser Asn Val Ile Ala Ser Leu Thr Cys Gly 
             180                185                190
Arg Arg Phe Glu Tyr Asp Asp Pro Arg Phe Leu Arg Leu Leu Asp Leu 
         195                200                205
Ala Gln Glu Gly Leu Lys Glu Glu Ser Gly Phe Leu Arg Glu Val Leu 
     210                215                220
Asn Ala Val Pro Val Leu Leu His Ile Pro Ala Leu Ala Gly Lys Val 
 225                230                235                240
Leu Arg Phe Gln Lys Ala Phe Leu Thr Gln Leu Asp Glu Leu Leu Thr 
                 245                250                255
Glu His Arg Met Thr Trp Asp Pro Ala Gln Pro Pro Arg Asp Leu Thr 
             260                265                270
Glu Ala Phe Leu Ala Glu Met Glu Lys Ala Lys Gly Asn Pro Glu Ser 
         275                280                285
Ser Phe Asn Asp Glu Asn Leu Arg Ile Val Val Ala Asp Leu Phe Ser 
     290                295                300
Ala Gly Met Val Thr Thr Ser Thr Thr Leu Ala Trp Gly Leu Leu Leu 
 305                310                315                320
Met Ile Leu His Pro Asp Val Gln Arg Arg Val Gln Gln Glu Ile Asp 
                 325                330                335
Asp Val Ile Gly Gln Val Arg Arg Pro Glu Met Gly Asp Gln Ala His 
             340                345                350
Met Pro Tyr Thr Thr Ala Val Ile His Glu Val Gln Arg Phe Gly Asp 
         355                360                365
Ile Val Pro Leu Gly Met Thr His Met Thr Ser Arg Asp Ile Glu Val 
     370                375                380
Gln Gly Phe Arg Ile Pro Lys Gly Thr Thr Leu Ile Thr Asn Leu Ser 
 385                390                395                400
Ser Val Leu Lys Asp Glu Ala Val Trp Glu Lys Pro Phe Arg Phe His 
                 405                410                415
Pro Glu His Phe Leu Asp Ala Gln Gly His Phe Val Lys Pro Glu Ala 
             420                425                430
Phe Leu Pro Phe Ser Ala Gly Arg Arg Ala Cys Leu Gly Glu Pro Leu 
         435                440                445
Ala Arg Met Glu Leu Phe Leu Phe Phe Thr Ser Leu Leu Gln His Phe 
     450                455                460
Ser Phe Ser Val Pro Thr Gly Gln Pro Arg Pro Ser His His Gly Val 
 465                470                475                480
Phe Ala Phe Leu Val Ser Pro Ser Pro Tyr Glu Leu Cys Ala Val Pro 
                 485                490                495
Arg 
             500



<210> 6468
<211> 522
<212> DNA
<213> Rattus norvegicus
<308> AI007614
<400> 6468

ggagagggt  gtcctggcc  agaactcag  catttttct  tgtaccaag  tttgcctaa  60
ttgtgcaga  ggttcttaa  aaagaaagg  aaggaaaag  aaatgtgtg  gtcttgttg  120
agggccaga  gttttgttg  gtaacagta  tagcaaggc  tgggctaag  gtttaatgt  180
cgttaagcc  aaagtgcgg  agcagctcc  ccacggtct  cacgcacca  aggaaaggc  240
agctttcct  tgggttctc  tttcgtttc  ttttgtttt  tgcctacct  aatgttctt  300
atgcattga  aggtgactt  gcttaatgg  tttggcaga  aacatttaa  gtttaattt  360
accttaata  caaaactac  tcgtgccga  ttcttggcc  cgagggcca  attccctat  420
gtgagtcgt  ttaaattcg  aatcatgtc  tagctgttt  ctgtgtgaa  ttgttatcc  480
ctcacaatt  cacacaaca  acgagccgg  agcataaag  gt  522



<210> 6469
<211> 569
<212> DNA
<213> Rattus norvegicus
<308> AI007824
<400> 6469

cctcactat  gggaataag  ttgcggacg  taaagtttt  ttttttttt  ttttttttt  60
tttttagta  tactttgac  tgtgagtct  ggttaaaat  attcggagg  ttttttatt  120
tccgaggtc  ccccaaccg  aatttttta  ttcatattt  ttttgtttt  gcccattag  180
ttgttttta  ataagttga  ctagtaaat  gaagctcca  agggtcttc  cgtcttatt  240
ggagattcc  gcctcttca  tggaaggtc  atttcactg  ttgaaagta  gagacagtt  300
aaccctcgt  tagccattc  ttctagtcc  taattaagg  acaagtgat  atgctacct  360
tgcacggtc  ggataccgc  gccgtttaa  tttagtcac  gggcaggca  tgcctctaa  420
acttgttat  ctagaggtg  tgtttttgg  aaacaggcg  ggttcgtgt  tgccgagtt  480
cttttactt  ttttaatct  tccttaaag  acgcctgtg  tgggctaac  agttaggga  540
aagtaattt  attgttggg  tagtaccta  569



<210> 6470
<211> 123
<212> PRT
<213> Rattus norvegicus
<308> CAA49904
<400> 6470

Met Glu Pro Cys Glu Leu Gln Asn Glu Leu Val Ser Ala Glu Gly Arg 
  1               5                  10                  15
Asn Arg Lys Ala Val Leu Cys Gln Arg Cys Gly Ser Arg Val Leu Gln 
             20                  25                  30
Pro Gly Thr Ala Leu Phe Ser Arg Arg Gln Leu Phe Leu Pro Ser Met 
         35                  40                  45
Arg Lys Lys Pro Asp Leu Val Asp Gly Ser Asn Pro Asp Gly Asp Val 
     50                  55                  60
Leu Glu Glu His Trp Leu Val Asn Asp Met Phe Ile Phe Glu Asn Val 
 65                  70                  75                  80
Gly Phe Thr Lys Asp Val Gly Asn Val Lys Phe Leu Val Cys Ala Asp 
                 85                  90                  95
Cys Glu Ile Gly Pro Ile Gly Trp His Cys Leu Asp Asp Lys Asn Ser 
             100                105                110
Phe Tyr Val Ala Leu Glu Arg Val Ser His Glu 
         115                120



<210> 6471
<211> 569
<212> DNA
<213> Rattus norvegicus
<308> AI007824
<400> 6471

cctcactat  gggaataag  ttgcggacg  taaagtttt  ttttttttt  ttttttttt  60
tttttagta  tactttgac  tgtgagtct  ggttaaaat  attcggagg  ttttttatt  120
tccgaggtc  ccccaaccg  aatttttta  ttcatattt  ttttgtttt  gcccattag  180
ttgttttta  ataagttga  ctagtaaat  gaagctcca  agggtcttc  cgtcttatt  240
ggagattcc  gcctcttca  tggaaggtc  atttcactg  ttgaaagta  gagacagtt  300
aaccctcgt  tagccattc  ttctagtcc  taattaagg  acaagtgat  atgctacct  360
tgcacggtc  ggataccgc  gccgtttaa  tttagtcac  gggcaggca  tgcctctaa  420
acttgttat  ctagaggtg  tgtttttgg  aaacaggcg  ggttcgtgt  tgccgagtt  480
cttttactt  ttttaatct  tccttaaag  acgcctgtg  tgggctaac  agttaggga  540
aagtaattt  attgttggg  tagtaccta  569



<210> 6472
<211> 123
<212> PRT
<213> Rattus norvegicus
<308> CAA49904
<400> 6472

Met Glu Pro Cys Glu Leu Gln Asn Glu Leu Val Ser Ala Glu Gly Arg 
  1               5                  10                  15
Asn Arg Lys Ala Val Leu Cys Gln Arg Cys Gly Ser Arg Val Leu Gln 
             20                  25                  30
Pro Gly Thr Ala Leu Phe Ser Arg Arg Gln Leu Phe Leu Pro Ser Met 
         35                  40                  45
Arg Lys Lys Pro Asp Leu Val Asp Gly Ser Asn Pro Asp Gly Asp Val 
     50                  55                  60
Leu Glu Glu His Trp Leu Val Asn Asp Met Phe Ile Phe Glu Asn Val 
 65                  70                  75                  80
Gly Phe Thr Lys Asp Val Gly Asn Val Lys Phe Leu Val Cys Ala Asp 
                 85                  90                  95
Cys Glu Ile Gly Pro Ile Gly Trp His Cys Leu Asp Asp Lys Asn Ser 
             100                105                110
Phe Tyr Val Ala Leu Glu Arg Val Ser His Glu 
         115                120



<210> 6474
<211> 433
<212> PRT
<213> Rattus norvegicus
<308> O08875
<400> 6474

Met Leu Glu Leu Ile Glu Val Asn Gly Thr Pro Gly Ser Gln Leu Ser 
  1               5                  10                  15
Thr Pro Arg Ser Gly Lys Ser Pro Ser Pro Ser Pro Thr Ser Pro Gly 
             20                  25                  30
Ser Leu Arg Lys Gln Arg Ile Ser Gln His Gly Gly Ser Ser Thr Ser 
         35                  40                  45
Leu Ser Ser Thr Lys Val Cys Ser Ser Met Asp Glu Asn Asp Gly Pro 
     50                  55                  60
Gly Glu Glu Glu Ser Asp Glu Gly Phe Gln Ile Pro Ala Thr Ile Thr 
 65                  70                  75                  80
Glu Arg Tyr Lys Val Gly Arg Thr Ile Gly Asp Gly Asn Phe Ala Val 
                 85                  90                  95
Val Lys Glu Cys Ile Glu Arg Ser Thr Ala Arg Glu Tyr Ala Leu Lys 
             100                105                110
Ile Ile Lys Lys Ser Lys Cys Arg Gly Lys Glu His Met Ile Gln Asn 
         115                120                125
Glu Val Ser Ile Leu Arg Arg Val Lys His Pro Asn Ile Val Leu Leu 
     130                135                140
Ile Glu Glu Met Asp Val Pro Thr Glu Leu Tyr Leu Val Met Glu Leu 
 145                150                155                160
Val Lys Gly Gly Asp Leu Phe Asp Ala Ile Thr Ser Thr Ser Lys Tyr 
                 165                170                175
Thr Glu Arg Asp Ala Ser Gly Met Leu Tyr Asn Leu Ala Ser Ala Ile 
             180                185                190
Lys Tyr Leu His Ser Leu Asn Ile Val His Arg Asp Ile Lys Pro Glu 
         195                200                205
Asn Leu Leu Val Tyr Glu His Gln Asp Gly Ser Lys Ser Leu Lys Leu 
     210                215                220
Gly Asp Phe Gly Leu Ala Thr Ile Val Asp Gly Pro Leu Tyr Thr Val 
 225                230                235                240
Cys Gly Thr Pro Thr Tyr Val Ala Pro Glu Ile Ile Ala Glu Thr Gly 
                 245                250                255
Tyr Gly Leu Lys Val Asp Ile Trp Ala Ala Gly Val Ile Thr Tyr Ile 
             260                265                270
Leu Leu Cys Gly Phe Pro Pro Phe Arg Gly Ser Gly Asp Asp Gln Glu 
         275                280                285
Val Leu Phe Asp Gln Ile Leu Met Gly Gln Val Asp Phe Pro Ser Pro 
     290                295                300
Tyr Trp Asp Asn Val Ser Asp Ser Ala Lys Glu Leu Ile Asn Met Met 
 305                310                315                320
Leu Leu Val Asn Val Asp Gln Arg Phe Ser Ala Val Gln Val Leu Glu 
                 325                330                335
His Pro Trp Val Asn Asp Asp Gly Leu Pro Glu Asn Glu His Gln Leu 
             340                345                350
Ser Val Ala Gly Lys Ile Lys Lys His Phe Asn Thr Gly Pro Lys Pro 
         355                360                365
Ser Ser Thr Ala Ala Gly Val Ser Val Ile Ala Thr Thr Ala Leu Asp 
     370                375                380
Lys Glu Arg Gln Val Phe Arg Arg Arg Arg Asn Gln Asp Val Arg Gly 
 385                390                395                400
Arg Tyr Lys Ala Gln Pro Ala Pro Pro Glu Leu Asn Ser Glu Ser Glu 
                 405                410                415
Asp Tyr Ser Pro Ser Ser Ser Glu Thr Val Arg Ser Pro Asn Ser Pro 
             420                425                430
Phe 
         435



<210> 6475
<211> 5703
<212> DNA
<213> Homo sapiens
<308> AB002367
<400> 6475

gcacatccc  gcactagtg  ccgcaaccg  gacgccgcg  tccagcagc  gctgccgcc  600
agcccggcc  cgccgccgc  ccccagccc  gcagccccg  agccccggc  gcgcccagc  660
cggcgagga  agcaccagg  ggcggcccc  agcgcggcc  caaagaccc  cggcggcgt  720
tctccgcgg  ccggtccta  ttgaagtcc  tcatgtcct  cggcagaga  atggagctg  780
agcacttcg  cgagcggga  aaggcgcag  gatacagcc  agggtcgcg  gtgaacggc  840
tgccgagcc  gacgcacag  gcccactgc  gcttctacc  cacccgcac  ctgcagacg  900
tcagctccg  gaagaaggc  aagaaagtt  gtttctatc  aaacggaga  cgatacttc  960
aagggattg  gtatgccat  tccccagac  ggttccgat  ttttgaggc  ctgctggct  1020
atttgaccc  aactctgtc  gataacgtg  atttgcccc  gggagtgag  acaatctac  1080
ccattgatg  gctcaagaa  atttccagc  tggaccaac  ggtggaagg  gagagttat  1140
tatgtggct  catagagcc  ttcaagaaa  tggagtaca  caagaatgt  aaccccaac  1200
ggtcggtga  cgtcaagac  acctcggct  ctcgggcag  gtcttcact  gccactgcc  1260
aaggaagcc  ttcagaggt  cgagagaat  aggatttca  tcggcccaa  ctggtcacc  1320
tcatcagaa  tggcgtgaa  ccacggaaa  ctgtcagga  tctgctgaa  aagaaaacg  1380
ctcattcct  tgagcaggt  ctcaccgat  tcaccgatg  catcaagct  gactcggga  1440
tggtgaaac  cctgtacac  ttggatggg  aacaggtga  gtgccttca  gactttttt  1500
gtgatgatg  catttttat  gcatgtgga  cggagaagt  ccgttacca  gatgatttc  1560
tgctagatg  aagtgaatg  cgagtggta  agtccactt  ttacaccaa  atagcttca  1620
catcccgca  gagcaccac  aagagccca  gaccgtcca  gcgtagcaa  tcccctgcc  1680
ccaccagct  agttaatgg  acccctggt  gtcagctct  tactccgcg  tcaggcaag  1740
cgccaagcc  atcacccac  agcccagga  gcctgcgga  gcagaggag  tctcagcat  1800
gcggctcct  tacgtcact  gcgtccacc  aagtctgca  ctcgatgga  gagaacgat  1860
gccctggag  agaagtgtc  gaggaaggc  tccagattc  agctacaat  acagaacga  1920
ataaagtcg  aagaacaat  ggagatgga  attttgctg  tgtcaagga  tgtgtagaa  1980
gatcgactg  tagagagta  gctctgaaa  ttatcaaga  aagcaaatg  cgaggcaaa  2040
agcacatga  ccagaatga  gtgtctatt  taagaagag  gaagcatcc  aatatcgtt  2100
ttctgattg  ggagatgga  gtgccaact  aactgtatc  tgtcatgga  ttagtaaag  2160
ggggagacc  ttttgatgc  attacttcc  ctaacaaat  caccgagag  gacgccagt  2220
ggatgctgt  caacctagc  agcgccatc  aatacctgc  tagcctgaa  atcgtccac  2280
gtgatatca  gccagagaa  ctgctggtg  atgagcacc  agatggcag  aaatcactg  2340
agctgggtg  ctttggact  gccaccatt  tagacggcc  cctgtacac  gtctgtggc  2400
ccccaacat  cgtggctcc  gaaatcatt  cagagactg  atacggcct  aaggtggac  2460
tctgggcag  aggtgtaat  acttatatc  tgctgtgtg  tttccctcc  ttccgtgga  2520
gtggtgatg  ccaggaggt  ctttttgat  agattttga  ggggcaggt  gactttcct  2580
ctccatact  ggataatgt  tccgattct  caaaggagc  cattaccat  atgctgttg  2640
tcgatgtag  tcagcgatt  tctgctgtt  aagtacttg  gcatccctg  gttaatgat  2700
atggcctcc  agaaaatga  catcagctg  cagtagctg  aaagataaa  aagcatttc  2760
acacaggcc  caagccgaa  agcacagca  ctggagttt  tgtcatagc  ctggaccac  2820
ggtttacca  caagagatc  gggtctttg  actactacc  gcaaccagg  atgtattgg  2880
taagaccac  gctcttgat  aggagaggc  ggttttccg  cgaagacgc  accaggatg  2940
gaggagccg  tacaaggcg  agccagctc  tcccgaact  aactcggaa  cggaagact  3000
ctccccaag  tcctccgag  ctgttcgct  ccctaactc  cccttttaa  aagaccctt  3060
tactcaaag  cctagctta  ccctttgag  ctctgagat  tttttcccc  aaatttgtg  3120
aaaacagtt  catctgatc  atctagcgc  caatgcttg  atggcagaa  tgaaagtgt  3180
ttcaggtat  tttgtagcg  tttcccttt  ctgaataag  tgacacgtg  tgattgtga  3240
gatggtaat  tgctgctaa  agagtcctc  aagggttaa  gccaatttg  aattttttt  3300
taaacttag  agcaatgaa  gttttcatc  gtcaagcta  gatctgcag  atgtaatat  3360
gcacttgtt  accctctga  tgcatagaa  tttattgag  attcttgtt  gggaatttt  3420
caggccttt  gatgtatac  cacatgttt  ttgatttta  tgcagatca  ggggtgttg  3480
tagatgctg  aatgtccag  aaagaagga  atttagaat  atatcttgt  tgtcctttt  3540
tgtgggttt  gaacgtggc  ggtttataa  ttagacaca  gcacggttc  ttcttcttc  3600
caatcctat  cagaaacag  ttttttttt  cattagaga  atgactgtc  gttgcagtg  3660
gttctgcat  ccaagtgga  ggaattggg  ttgtggcaa  gagcttgac  caggaaata  3720
atggtgccc  ccaaattgt  tccacatga  gatgtactg  tgacgcccc  gaaatgctg  3780
ttccatatc  gctgctgct  gcgccagcg  agactctca  ggagtcacc  cagcttgtc  3840
tgtgcttgg  gagtgaggg  ctctctact  agtgtcaga  atctacagg  aagaaacaa  3900
tggtggaaa  gagcaataa  ttgcccggt  ctctgcagg  ctggaattt  aaacagaaa  3960
agggaataa  atcctgtga  ttttctcac  tgcttttcc  cgcactgtg  tcatcactg  4020
gcaatctac  tctagtatg  aatccacac  taggagagc  ggggcacaa  gggactgga  4080
gcagttgct  tgcaagatg  ctgaggaga  agcacactg  gaacacaat  cagaatgtt  4140
taacaataa  ttttcagtg  ataaaccac  ggcaagaca  ttccatgtg  acctttagg  4200
tacctatat  gtctcctag  aagatcagg  tgaaagacc  agatgatac  cctgaggat  4260
aaacctcca  cccctaaaa  gattttttt  aaataccac  gtctttagc  gtccaggag  4320
tcagagtgt  ttttctgtc  ttgggccaa  tcctgtctg  gacctgtat  ttcactctt  4380
ttaccaaat  tatctccct  gtgcagtgt  tccaggcct  agtttcttc  ggaacagat  4440
ccattttag  atggggatt  acaggttct  tgcatcacc  cagtgctca  agaggattc  4500
cctggggtg  cttagaggc  ggtgcccaa  tcaaatgta  tcccaaggt  tgctgggct  4560
tgggatcca  gagacaacc  gagagggat  tctcatgaa  tttgcatct  gtggctgaa  4620
agtacctat  ttctctgtt  tgaatatac  ttaatacct  agagtctta  aatttgtga  4680
caacgtttc  atagtcctt  attttcaaa  gcacattga  cttcacttg  tgcattttt  4740
ctcttcaac  ctgaaacta  ggtctacat  aatatggat  tttaaatca  atgtcatta  4800
ttttgcaac  ccatcacca  aattttttg  tcttttaca  ttaggttca  ctctgtggt  4860
tgtgttgtc  tgacatgta  aaagcatat  gtttattga  gtttttttc  ccccctttt  4920
gagcatccg  aagtgataa  acgcaaaat  acaaagtag  ataaatcag  aaattagtt  4980
agttgtttt  gggggggag  tgggggtag  gggcacaga  caccagaaa  agtgttggt  5040
tgtaggtag  ttccatatt  atgaggaac  ctgaactag  tggaaatta  tgctttctc  5100
agaaatata  agcaaagca  tattccaag  ctatggagt  gctctacag  ctggcctca  5160
ctctaaaag  gtgaagaat  caatgggca  agacctacc  gcagtggac  gtcattttc  5220
tttctttct  tgaattact  ctttttctg  gggcattaa  tatattgct  cagcatcta  5280
tgtactgag  ctgcggtgc  tggctcagg  cttttccca  cgacgtcta  ggggactct  5340
gaccgtgtg  agctagggg  tgtttctca  cacactgca  aagggcagc  cagaagaat  5400
cagggccca  tcagcatgg  gatcccagc  catcactgt  gaatttgag  gatctatgc  5460
gaataaaca  tggaatgtg  ccagtcaag  agaaatctt  agtaatcag  tggaatgca  5520
tctttctaa  attaagcta  caagatcct  aatgtcaga  atgtactca  agggttaac  5580
gacaagcac  aggcatgct  actacattg  tgtatccag  ttgctttgc  tttagccag  5640
gctttctaa  ttttttctc  acattcttg  gatagttca  gtttgaaat  attaagtgg  5700
ggt  5703



<210> 6476
<211> 740
<212> PRT
<213> Homo sapiens
<308> O15075
<400> 6476

Met Ser Phe Gly Arg Asp Met Glu Leu Glu His Phe Asp Glu Arg Asp 
  1               5                  10                  15
Lys Ala Gln Arg Tyr Ser Arg Gly Ser Arg Val Asn Gly Leu Pro Ser 
             20                  25                  30
Pro Thr His Ser Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln 
         35                  40                  45
Thr Leu Ser Ser Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn 
     50                  55                  60
Gly Asp Arg Tyr Phe Lys Gly Ile Val Tyr Ala Ile Ser Pro Asp Arg 
 65                  70                  75                  80
Phe Arg Ser Phe Glu Ala Leu Leu Ala Asp Leu Thr Arg Thr Leu Ser 
                 85                  90                  95
Asp Asn Val Asn Leu Pro Gln Gly Val Arg Thr Ile Tyr Thr Ile Asp 
             100                105                110
Gly Leu Lys Lys Ile Ser Ser Leu Asp Gln Leu Val Glu Gly Glu Ser 
         115                120                125
Tyr Val Cys Gly Ser Ile Glu Pro Phe Lys Lys Leu Glu Tyr Thr Lys 
     130                135                140
Asn Val Asn Pro Asn Trp Ser Val Asn Val Lys Thr Thr Ser Ala Ser 
 145                150                155                160
Arg Ala Val Ser Ser Leu Ala Thr Ala Lys Gly Ser Pro Ser Glu Val 
                 165                170                175
Arg Glu Asn Lys Asp Phe Ile Arg Pro Lys Leu Val Thr Ile Ile Arg 
             180                185                190
Ser Gly Val Lys Pro Arg Lys Ala Val Arg Ile Leu Leu Asn Lys Lys 
         195                200                205
Thr Ala His Ser Phe Glu Gln Val Leu Thr Asp Ile Thr Asp Ala Ile 
     210                215                220
Lys Leu Asp Ser Gly Val Val Lys Arg Leu Tyr Thr Leu Asp Gly Lys 
 225                230                235                240
Gln Val Met Cys Leu Gln Asp Phe Phe Gly Asp Asp Asp Ile Phe Ile 
                 245                250                255
Ala Cys Gly Pro Glu Lys Phe Arg Tyr Gln Asp Asp Phe Leu Leu Asp 
             260                265                270
Glu Ser Glu Cys Arg Val Val Lys Ser Thr Ser Tyr Thr Lys Ile Ala 
         275                280                285
Ser Ser Ser Arg Arg Ser Thr Thr Lys Ser Pro Gly Pro Ser Arg Arg 
     290                295                300
Ser Lys Ser Pro Ala Ser Thr Ser Ser Val Asn Gly Thr Pro Gly Ser 
 305                310                315                320
Gln Leu Ser Thr Pro Arg Ser Gly Lys Ser Pro Ser Pro Ser Pro Thr 
                 325                330                335
Ser Pro Gly Ser Leu Arg Lys Gln Arg Ser Ser Gln His Gly Gly Ser 
             340                345                350
Ser Thr Ser Leu Ala Ser Thr Lys Val Cys Ser Ser Met Asp Glu Asn 
         355                360                365
Asp Gly Pro Gly Glu Glu Val Ser Glu Glu Gly Phe Gln Ile Pro Ala 
     370                375                380
Thr Ile Thr Glu Arg Tyr Lys Val Gly Arg Thr Ile Gly Asp Gly Asn 
 385                390                395                400
Phe Ala Val Val Lys Glu Cys Val Glu Arg Ser Thr Ala Arg Glu Tyr 
                 405                410                415
Ala Leu Lys Ile Ile Lys Lys Ser Lys Cys Arg Gly Lys Glu His Met 
             420                425                430
Ile Gln Asn Glu Val Ser Ile Leu Arg Arg Val Lys His Pro Asn Ile 
         435                440                445
Val Leu Leu Ile Glu Glu Met Asp Val Pro Thr Glu Leu Tyr Leu Val 
     450                455                460
Met Glu Leu Val Lys Gly Gly Asp Leu Phe Asp Ala Ile Thr Ser Thr 
 465                470                475                480
Asn Lys Tyr Thr Glu Arg Asp Ala Ser Gly Met Leu Tyr Asn Leu Ala 
                 485                490                495
Ser Ala Ile Lys Tyr Leu His Ser Leu Asn Ile Val His Arg Asp Ile 
             500                505                510
Lys Pro Glu Asn Leu Leu Val Tyr Glu His Gln Asp Gly Ser Lys Ser 
         515                520                525
Leu Lys Leu Gly Asp Phe Gly Leu Ala Thr Ile Val Asp Gly Pro Leu 
     530                535                540
Tyr Thr Val Cys Gly Thr Pro Thr Tyr Val Ala Pro Glu Ile Ile Ala 
 545                550                555                560
Glu Thr Gly Tyr Gly Leu Lys Val Asp Ile Trp Ala Ala Gly Val Ile 
                 565                570                575
Thr Tyr Ile Leu Leu Cys Gly Phe Pro Pro Phe Arg Gly Ser Gly Asp 
             580                585                590
Asp Gln Glu Val Leu Phe Asp Gln Ile Leu Met Gly Gln Val Asp Phe 
         595                600                605
Pro Ser Pro Tyr Trp Asp Asn Val Ser Asp Ser Ala Lys Glu Leu Ile 
     610                615                620
Thr Met Met Leu Leu Val Asp Val Asp Gln Arg Phe Ser Ala Val Gln 
 625                630                635                640
Val Leu Glu His Pro Trp Val Asn Asp Asp Gly Leu Pro Glu Asn Glu 
                 645                650                655
His Gln Leu Ser Val Ala Gly Lys Ile Lys Lys His Phe Asn Thr Gly 
             660                665                670
Pro Lys Pro Asn Ser Thr Ala Ala Gly Val Ser Val Ile Ala Thr Thr 
         675                680                685
Ala Leu Asp Lys Glu Arg Gln Val Phe Arg Arg Arg Arg Asn Gln Asp 
     690                695                700
Val Arg Ser Arg Tyr Lys Ala Gln Pro Ala Pro Pro Glu Leu Asn Ser 
 705                710                715                720
Glu Ser Glu Asp Tyr Ser Pro Ser Ser Ser Glu Thr Val Arg Ser Pro 
                 725                730                735
Asn Ser Pro Phe 
             740



<210> 6477
<211> 496
<212> DNA
<213> Rattus norvegicus
<308> AI008131
<400> 6477

agcaaaact  gtaaaaaca  aattgtaat  gttgaacat  gcgctctgg  aatcaagac  60
tttgaaacc  tcaatcttc  ggggcgaag  aagcactgt  cgacactta  aactctgat  120
aacagacaa  gtggtcaca  attttcctg  cttgaagac  tccacaact  tcctgatca  180
gtcatcata  gaggtctga  ttaggtttg  ttcaaagct  acataagaa  attctggtt  240
tggagtgat  tgaatattc  aatatgttc  atccgattt  attccattc  ttgagtagc  300
acaaggatt  aacagtgtg  catcaatga  agaacctgg  atcaggtca  gaattccac  360
ctcacgagt  acatccttt  cagtaacac  atctttcat  tagaactgg  ccataactg  420
tgggtcaag  tcactcatc  gaatttcca  ggtttgatc  ggctgattg  ttactcggc  480
ctctgggag  ctcgtg  496



<210> 6478
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> P17708
<400> 6478

Met Glu Ala Ala His Phe Phe Glu Gly Thr Glu Lys Leu Leu Glu Val 
  1               5                  10                  15
Trp Phe Ser Arg Gln Gln Ser Asp Ala Ser Gln Gly Ser Gly Asp Leu 
             20                  25                  30
Arg Thr Ile Pro Arg Ser Glu Trp Asp Val Leu Leu Lys Asp Val Gln 
         35                  40                  45
Cys Ser Ile Ile Ser Val Thr Lys Thr Asp Lys Gln Glu Ala Tyr Val 
     50                  55                  60
Leu Ser Glu Ser Ser Met Phe Val Ser Lys Arg Arg Phe Ile Leu Lys 
 65                  70                  75                  80
Thr Cys Gly Thr Thr Leu Leu Leu Lys Ala Leu Val Pro Leu Leu Lys 
                 85                  90                  95
Leu Ala Arg Asp Tyr Ser Gly Phe Asp Ser Ile Gln Ser Phe Phe Tyr 
             100                105                110
Ser Arg Lys Asn Phe Met Lys Pro Ser His Gln Gly Tyr Pro His Arg 
         115                120                125
Asn Phe Gln Glu Glu Ile Glu Phe Leu Asn Ala Ile Phe Pro Asn Gly 
     130                135                140
Ala Ala Tyr Cys Met Gly Arg Met Asn Ser Asp Cys Trp Tyr Leu Tyr 
 145                150                155                160
Thr Leu Asp Leu Pro Glu Ser Arg Val Ile Asn Gln Pro Asp Gln Thr 
                 165                170                175
Leu Glu Ile Leu Met Ser Glu Leu Asp Pro Ala Val Met Asp Gln Phe 
             180                185                190
Tyr Met Lys Asp Gly Val Thr Ala Lys Asp Val Thr Arg Glu Ser Gly 
         195                200                205
Ile Arg Asp Leu Ile Pro Gly Ser Val Ile Asp Ala Thr Leu Phe Asn 
     210                215                220
Pro Cys Gly Tyr Ser Met Asn Gly Met Lys Ser Asp Gly Thr Tyr Trp 
 225                230                235                240
Thr Ile His Ile Thr Pro Glu Pro Glu Phe Ser Tyr Val Ser Phe Glu 
                 245                250                255
Thr Asn Leu Ser Gln Thr Ser Tyr Asp Asp Leu Ile Arg Lys Val Val 
             260                265                270
Glu Val Phe Lys Pro Gly Lys Phe Val Thr Thr Leu Phe Val Asn Gln 
         275                280                285
Ser Ser Lys Cys Arg Thr Val Leu Ser Ser Pro Gln Lys Ile Asp Gly 
     290                295                300
Phe Lys Arg Leu Asp Cys Gln Ser Ala Met Phe Asn Asp Tyr Asn Phe 
 305                310                315                320
Val Phe Thr Ser Phe Ala Lys Lys Gln Gln Gln Gln Ser 
                 325                330



<210> 6479
<211> 1686
<212> DNA
<213> Homo sapiens
<308> BC000171
<400> 6479

ctggaacaa  ccgcagcgg  ggcggcagc  gcgggagaa  aggtttaat  tagttgatt  60
tctgtggtt  ttggttgtt  gctagtctc  cggtgatgg  agctgcaca  tttttcgaa  120
ggaccgaga  gctgctgga  gtttggttc  cccggcagc  gcccgacgc  aaccaagga  180
ctggggatc  tcgcactat  ccaagatct  agtgggaca  acttttgaa  gatgtgcaa  240
gttcaatca  aagtgtgac  aaaactgac  agcaggaag  ttatgtact  agtgagagt  300
gcatgtttg  ctccaagag  cgtttcatt  tgaagacat  tggtaccac  ctcttgctg  360
aagcactgg  tcccctgtt  aagcttgct  gggattaca  tgggtttga  tcaattcaa  420
gcttctttt  ttctcgtaa  aatttcatg  agccttctc  ccaagggta  ccacaccgg  480
atttccagg  agaaataga  tttcttaat  caattttcc  aaatggagc  gcatattgt  540
tgggacgta  gaattctga  tgttggtac  tatatactc  ggatttccc  gagagtcgg  600
taatcagtc  gccagatca  accttggaa  ttctgatga  tgagcttga  ccagcagtt  660
tggaccagt  ctacatgaa  gatggtgtt  ctgcaaagg  tgtcactcg  gagagtgga  720
ttcgtgacc  gataccagg  tctgtcatt  atgccacaa  gttcaatcc  tgtgggtat  780
cgatgaatg  aatgaaatc  gatggaact  attggacta  tcacatcac  ccagaacca  840
aattttctt  tgttagctt  gaaacaaac  taagtcaga  ctcctatga  gacctgatc  900
ggaaagttg  agaagtctt  aagccagga  aatttgtga  caccttgtt  gttaatcag  960
gttctaaat  tcgcacagt  cttgcttcg  cccagaaga  tgaaggttt  aagcgtctt  1020
attgccaga  tgctatgtt  aatgattac  attttgttt  taccagttt  gctaagaag  1080
agcaacaac  gcagagttg  ttaagaaaa  tgaagaaaa  acgcaaaaa  agaacacat  1140
tagaaggtg  tggatgctt  ctagatgtc  atgctgggg  cagtgcttt  cataaccac  1200
actgtgtag  tgcagaaag  cctagatgt  atgatagtg  aatcatttt  aattgtatg  1260
attattata  caaggagtt  gatatcttg  atgaatgct  tcttctgtg  ttaggtatt  1320
tctgccact  ttgctgtga  attgaagtg  atgtagaaa  aacctttta  tatatgaaa  1380
tttacaaca  ttgtgaaag  aactcaatt  ggtttatgc  cagtgtaat  tttctccaa  1440
tatcatcca  aattcccca  agacaaggc  ttcgtcctc  ttaggtgtt  gcctcagcc  1500
aaccctcta  gactgttct  ttaaattgc  gccagaatt  tacatccag  tacctccac  1560
ttctagaac  tattcttta  taatgttat  gaaaccaat  tctacttca  actgatgtt  1620
ttggaaaca  caattaaag  ttttcttcc  tgagttgag  ccttaaaaa  aaaaaaaaa  1680
aaaaaa  1686



<210> 6480
<211> 334
<212> PRT
<213> Homo sapiens
<308> P17707
<400> 6480

Met Glu Ala Ala His Phe Phe Glu Gly Thr Glu Lys Leu Leu Glu Val 
  1               5                  10                  15
Trp Phe Ser Arg Gln Gln Pro Asp Ala Asn Gln Gly Ser Gly Asp Leu 
             20                  25                  30
Arg Thr Ile Pro Arg Ser Glu Trp Asp Ile Leu Leu Lys Asp Val Gln 
         35                  40                  45
Cys Ser Ile Ile Ser Val Thr Lys Thr Asp Lys Gln Glu Ala Tyr Val 
     50                  55                  60
Leu Ser Glu Ser Ser Met Phe Val Ser Lys Arg Arg Phe Ile Leu Lys 
 65                  70                  75                  80
Thr Cys Gly Thr Thr Leu Leu Leu Lys Ala Leu Val Pro Leu Leu Lys 
                 85                  90                  95
Leu Ala Arg Asp Tyr Ser Gly Phe Asp Ser Ile Gln Ser Phe Phe Tyr 
             100                105                110
Ser Arg Lys Asn Phe Met Lys Pro Ser His Gln Gly Tyr Pro His Arg 
         115                120                125
Asn Phe Gln Glu Glu Ile Glu Phe Leu Asn Ala Ile Phe Pro Asn Gly 
     130                135                140
Ala Gly Tyr Cys Met Gly Arg Met Asn Ser Asp Cys Trp Tyr Leu Tyr 
 145                150                155                160
Thr Leu Asp Phe Pro Glu Ser Arg Val Ile Ser Gln Pro Asp Gln Thr 
                 165                170                175
Leu Glu Ile Leu Met Ser Glu Leu Asp Pro Ala Val Met Asp Gln Phe 
             180                185                190
Tyr Met Lys Asp Gly Val Thr Ala Lys Asp Val Thr Arg Glu Ser Gly 
         195                200                205
Ile Arg Asp Leu Ile Pro Gly Ser Val Ile Asp Ala Thr Met Phe Asn 
     210                215                220
Pro Cys Gly Tyr Ser Met Asn Gly Met Lys Ser Asp Gly Thr Tyr Trp 
 225                230                235                240
Thr Ile His Ile Thr Pro Glu Pro Glu Phe Ser Tyr Val Ser Phe Glu 
                 245                250                255
Thr Asn Leu Ser Gln Thr Ser Tyr Asp Asp Leu Ile Arg Lys Val Val 
             260                265                270
Glu Val Phe Lys Pro Gly Lys Phe Val Thr Thr Leu Phe Val Asn Gln 
         275                280                285
Ser Ser Lys Cys Arg Thr Val Leu Ala Ser Pro Gln Lys Ile Glu Gly 
     290                295                300
Phe Lys Arg Leu Asp Cys Gln Ser Ala Met Phe Asn Asp Tyr Asn Phe 
 305                310                315                320
Val Phe Thr Ser Phe Ala Lys Lys Gln Gln Gln Gln Gln Ser 
                 325                330



<210> 6481
<211> 496
<212> DNA
<213> Rattus norvegicus
<308> AI008131
<400> 6481

agcaaaact  gtaaaaaca  aattgtaat  gttgaacat  gcgctctgg  aatcaagac  60
tttgaaacc  tcaatcttc  ggggcgaag  aagcactgt  cgacactta  aactctgat  120
aacagacaa  gtggtcaca  attttcctg  cttgaagac  tccacaact  tcctgatca  180
gtcatcata  gaggtctga  ttaggtttg  ttcaaagct  acataagaa  attctggtt  240
tggagtgat  tgaatattc  aatatgttc  atccgattt  attccattc  ttgagtagc  300
acaaggatt  aacagtgtg  catcaatga  agaacctgg  atcaggtca  gaattccac  360
ctcacgagt  acatccttt  cagtaacac  atctttcat  tagaactgg  ccataactg  420
tgggtcaag  tcactcatc  gaatttcca  ggtttgatc  ggctgattg  ttactcggc  480
ctctgggag  ctcgtg  496



<210> 6482
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> P17708
<400> 6482

Met Glu Ala Ala His Phe Phe Glu Gly Thr Glu Lys Leu Leu Glu Val 
  1               5                  10                  15
Trp Phe Ser Arg Gln Gln Ser Asp Ala Ser Gln Gly Ser Gly Asp Leu 
             20                  25                  30
Arg Thr Ile Pro Arg Ser Glu Trp Asp Val Leu Leu Lys Asp Val Gln 
         35                  40                  45
Cys Ser Ile Ile Ser Val Thr Lys Thr Asp Lys Gln Glu Ala Tyr Val 
     50                  55                  60
Leu Ser Glu Ser Ser Met Phe Val Ser Lys Arg Arg Phe Ile Leu Lys 
 65                  70                  75                  80
Thr Cys Gly Thr Thr Leu Leu Leu Lys Ala Leu Val Pro Leu Leu Lys 
                 85                  90                  95
Leu Ala Arg Asp Tyr Ser Gly Phe Asp Ser Ile Gln Ser Phe Phe Tyr 
             100                105                110
Ser Arg Lys Asn Phe Met Lys Pro Ser His Gln Gly Tyr Pro His Arg 
         115                120                125
Asn Phe Gln Glu Glu Ile Glu Phe Leu Asn Ala Ile Phe Pro Asn Gly 
     130                135                140
Ala Ala Tyr Cys Met Gly Arg Met Asn Ser Asp Cys Trp Tyr Leu Tyr 
 145                150                155                160
Thr Leu Asp Leu Pro Glu Ser Arg Val Ile Asn Gln Pro Asp Gln Thr 
                 165                170                175
Leu Glu Ile Leu Met Ser Glu Leu Asp Pro Ala Val Met Asp Gln Phe 
             180                185                190
Tyr Met Lys Asp Gly Val Thr Ala Lys Asp Val Thr Arg Glu Ser Gly 
         195                200                205
Ile Arg Asp Leu Ile Pro Gly Ser Val Ile Asp Ala Thr Leu Phe Asn 
     210                215                220
Pro Cys Gly Tyr Ser Met Asn Gly Met Lys Ser Asp Gly Thr Tyr Trp 
 225                230                235                240
Thr Ile His Ile Thr Pro Glu Pro Glu Phe Ser Tyr Val Ser Phe Glu 
                 245                250                255
Thr Asn Leu Ser Gln Thr Ser Tyr Asp Asp Leu Ile Arg Lys Val Val 
             260                265                270
Glu Val Phe Lys Pro Gly Lys Phe Val Thr Thr Leu Phe Val Asn Gln 
         275                280                285
Ser Ser Lys Cys Arg Thr Val Leu Ser Ser Pro Gln Lys Ile Asp Gly 
     290                295                300
Phe Lys Arg Leu Asp Cys Gln Ser Ala Met Phe Asn Asp Tyr Asn Phe 
 305                310                315                320
Val Phe Thr Ser Phe Ala Lys Lys Gln Gln Gln Gln Ser 
                 325                330



<210> 6483
<211> 1686
<212> DNA
<213> Homo sapiens
<308> BC000171
<400> 6483

ctggaacaa  ccgcagcgg  ggcggcagc  gcgggagaa  aggtttaat  tagttgatt  60
tctgtggtt  ttggttgtt  gctagtctc  cggtgatgg  agctgcaca  tttttcgaa  120
ggaccgaga  gctgctgga  gtttggttc  cccggcagc  gcccgacgc  aaccaagga  180
ctggggatc  tcgcactat  ccaagatct  agtgggaca  acttttgaa  gatgtgcaa  240
gttcaatca  aagtgtgac  aaaactgac  agcaggaag  ttatgtact  agtgagagt  300
gcatgtttg  ctccaagag  cgtttcatt  tgaagacat  tggtaccac  ctcttgctg  360
aagcactgg  tcccctgtt  aagcttgct  gggattaca  tgggtttga  tcaattcaa  420
gcttctttt  ttctcgtaa  aatttcatg  agccttctc  ccaagggta  ccacaccgg  480
atttccagg  agaaataga  tttcttaat  caattttcc  aaatggagc  gcatattgt  540
tgggacgta  gaattctga  tgttggtac  tatatactc  ggatttccc  gagagtcgg  600
taatcagtc  gccagatca  accttggaa  ttctgatga  tgagcttga  ccagcagtt  660
tggaccagt  ctacatgaa  gatggtgtt  ctgcaaagg  tgtcactcg  gagagtgga  720
ttcgtgacc  gataccagg  tctgtcatt  atgccacaa  gttcaatcc  tgtgggtat  780
cgatgaatg  aatgaaatc  gatggaact  attggacta  tcacatcac  ccagaacca  840
aattttctt  tgttagctt  gaaacaaac  taagtcaga  ctcctatga  gacctgatc  900
ggaaagttg  agaagtctt  aagccagga  aatttgtga  caccttgtt  gttaatcag  960
gttctaaat  tcgcacagt  cttgcttcg  cccagaaga  tgaaggttt  aagcgtctt  1020
attgccaga  tgctatgtt  aatgattac  attttgttt  taccagttt  gctaagaag  1080
agcaacaac  gcagagttg  ttaagaaaa  tgaagaaaa  acgcaaaaa  agaacacat  1140
tagaaggtg  tggatgctt  ctagatgtc  atgctgggg  cagtgcttt  cataaccac  1200
actgtgtag  tgcagaaag  cctagatgt  atgatagtg  aatcatttt  aattgtatg  1260
attattata  caaggagtt  gatatcttg  atgaatgct  tcttctgtg  ttaggtatt  1320
tctgccact  ttgctgtga  attgaagtg  atgtagaaa  aacctttta  tatatgaaa  1380
tttacaaca  ttgtgaaag  aactcaatt  ggtttatgc  cagtgtaat  tttctccaa  1440
tatcatcca  aattcccca  agacaaggc  ttcgtcctc  ttaggtgtt  gcctcagcc  1500
aaccctcta  gactgttct  ttaaattgc  gccagaatt  tacatccag  tacctccac  1560
ttctagaac  tattcttta  taatgttat  gaaaccaat  tctacttca  actgatgtt  1620
ttggaaaca  caattaaag  ttttcttcc  tgagttgag  ccttaaaaa  aaaaaaaaa  1680
aaaaaa  1686



<210> 6484
<211> 334
<212> PRT
<213> Homo sapiens
<308> P17707
<400> 6484

Met Glu Ala Ala His Phe Phe Glu Gly Thr Glu Lys Leu Leu Glu Val 
  1               5                  10                  15
Trp Phe Ser Arg Gln Gln Pro Asp Ala Asn Gln Gly Ser Gly Asp Leu 
             20                  25                  30
Arg Thr Ile Pro Arg Ser Glu Trp Asp Ile Leu Leu Lys Asp Val Gln 
         35                  40                  45
Cys Ser Ile Ile Ser Val Thr Lys Thr Asp Lys Gln Glu Ala Tyr Val 
     50                  55                  60
Leu Ser Glu Ser Ser Met Phe Val Ser Lys Arg Arg Phe Ile Leu Lys 
 65                  70                  75                  80
Thr Cys Gly Thr Thr Leu Leu Leu Lys Ala Leu Val Pro Leu Leu Lys 
                 85                  90                  95
Leu Ala Arg Asp Tyr Ser Gly Phe Asp Ser Ile Gln Ser Phe Phe Tyr 
             100                105                110
Ser Arg Lys Asn Phe Met Lys Pro Ser His Gln Gly Tyr Pro His Arg 
         115                120                125
Asn Phe Gln Glu Glu Ile Glu Phe Leu Asn Ala Ile Phe Pro Asn Gly 
     130                135                140
Ala Gly Tyr Cys Met Gly Arg Met Asn Ser Asp Cys Trp Tyr Leu Tyr 
 145                150                155                160
Thr Leu Asp Phe Pro Glu Ser Arg Val Ile Ser Gln Pro Asp Gln Thr 
                 165                170                175
Leu Glu Ile Leu Met Ser Glu Leu Asp Pro Ala Val Met Asp Gln Phe 
             180                185                190
Tyr Met Lys Asp Gly Val Thr Ala Lys Asp Val Thr Arg Glu Ser Gly 
         195                200                205
Ile Arg Asp Leu Ile Pro Gly Ser Val Ile Asp Ala Thr Met Phe Asn 
     210                215                220
Pro Cys Gly Tyr Ser Met Asn Gly Met Lys Ser Asp Gly Thr Tyr Trp 
 225                230                235                240
Thr Ile His Ile Thr Pro Glu Pro Glu Phe Ser Tyr Val Ser Phe Glu 
                 245                250                255
Thr Asn Leu Ser Gln Thr Ser Tyr Asp Asp Leu Ile Arg Lys Val Val 
             260                265                270
Glu Val Phe Lys Pro Gly Lys Phe Val Thr Thr Leu Phe Val Asn Gln 
         275                280                285
Ser Ser Lys Cys Arg Thr Val Leu Ala Ser Pro Gln Lys Ile Glu Gly 
     290                295                300
Phe Lys Arg Leu Asp Cys Gln Ser Ala Met Phe Asn Asp Tyr Asn Phe 
 305                310                315                320
Val Phe Thr Ser Phe Ala Lys Lys Gln Gln Gln Gln Gln Ser 
                 325                330



<210> 6485
<211> 512
<212> DNA
<213> Rattus norvegicus
<308> AI008423
<400> 6485

agtgcacga  tgctctttt  ttactttaa  aatatttat  agaaatgta  atttaattc  60
ttttaagga  tggtctaga  aagtgttaa  atcacctcg  atttgtaaa  ctttacatc  120
tgaagctat  tacagattt  caagaactc  tcccttccc  acaccagac  ggacagcta  180
gggcactgt  acttcactc  gtacttgta  aaggaacac  gcgtgtggg  aaagttcca  240
cccagcgcc  gtgatagtc  gtacagcac  atgagaggt  caaatggat  gagcaggac  300
actgtattt  tcaaaaatg  caatgcact  tatcccagg  aggtcacat  gatataata  360
ccaaccgcg  tcaaccata  ggtatttcc  actaaatat  caataaacg  gtctgtgag  420
ataacatgg  tgatgaaga  gagctggat  aaatgcagg  tgacgagga  cggatagaa  480
gcattcaag  gcacgtcga  ggcgtagcc  ca  512



<210> 6486
<211> 259
<212> PRT
<213> Rattus norvegicus
<308> AAB93932
<400> 6486

Met Leu Pro Ser Thr Ser Leu Asn Ser Ser Met Tyr Gly Asn Gly Ala 
  1               5                  10                  15
Leu Asn Ser Arg Asp Ala Ala Arg His Thr Ala Gly Ala Lys Arg Tyr 
             20                  25                  30
Lys Tyr Leu Arg Arg Leu Phe Arg Phe Arg Gln Met Asp Phe Glu Phe 
         35                  40                  45
Ala Ala Trp Gln Met Leu Tyr Leu Phe Thr Ser Pro Gln Arg Val Tyr 
     50                  55                  60
Arg Asn Phe His Tyr Arg Lys Gln Thr Lys Asp Gln Trp Ala Arg Asp 
 65                  70                  75                  80
Asp Pro Ala Phe Leu Val Leu Leu Ser Ile Trp Leu Cys Val Ser Thr 
                 85                  90                  95
Ile Gly Phe Gly Phe Val Leu Asp Met Gly Phe Phe Glu Thr Ile Lys 
             100                105                110
Leu Leu Leu Trp Val Val Phe Ile Asp Cys Val Gly Val Gly Leu Leu 
         115                120                125
Ile Ser Thr Leu Met Trp Phe Ile Ser Asn Lys Tyr Leu Val Lys Arg 
     130                135                140
Gln Ser Arg Asp Tyr Asp Val Glu Trp Gly Tyr Ala Phe Asp Val His 
 145                150                155                160
Leu Asn Ala Phe Tyr Pro Leu Leu Val Ile Leu His Phe Ile Gln Leu 
                 165                170                175
Phe Phe Ile Asn His Val Ile Leu Thr Asp Thr Phe Ile Gly Tyr Leu 
             180                185                190
Val Gly Asn Thr Leu Trp Leu Ile Ala Val Gly Tyr Tyr Ile Tyr Val 
         195                200                205
Thr Phe Leu Gly Tyr Ser Ala Leu Pro Phe Leu Lys Asn Thr Val Val 
     210                215                220
Leu Leu Tyr Pro Phe Ala Pro Leu Ile Val Leu Tyr Gly Leu Ser Leu 
 225                230                235                240
Ala Leu Gly Trp Asn Phe Thr His Thr Leu Cys Ser Phe Tyr Lys Tyr 
                 245                250                255
Arg Val Lys 
             260



<210> 6487
<211> 1094
<212> DNA
<213> Homo sapiens
<308> AF077038
<400> 6487

gttgaggga  gggaagccc  cccggtggc  ctggggtcg  ctgctggga  gaggtggtg  60
gctggttcg  acgtgggtc  aggctgtag  aggactcca  gaagatgtt  ccgagtact  120
cagtgaatt  cttagtgca  gggaacgga  tcttgaatt  cagggatgc  gcaagacac  180
cagccggag  gaaacgcta  aaatatctg  gaaggcttt  ccgctttcg  caaatggac  240
ttgaatttg  tgcctggca  atgctctac  tgttcacat  cccacagag  gtttacaga  300
attttcatt  tcgaaaaca  acgaaggac  agtgggcca  agatgaccc  gctttcttg  360
tcctgttaa  tatctggct  tgtgtgtcc  ctataggat  tggctttgt  ctggacatg  420
gattctttg  gacaataaa  cttctcctt  gggttgtac  catagattg  gtaggcgtt  480
gtcttctga  agcaacttt  atgtggttc  tctctaaca  gtatttagt  aaacgacag  540
gcagagact  tgatgtgga  tggggctat  cttttgatg  gcatctcaa  gctttttat  600
cactcctgg  cattttgca  tttatccag  tttttttca  caaccatgt  atcctgaca  660
acacattta  tggatattt  gttggaaat  ccttatggt  ggttgcagt  ggctattat  720
tctatgtaa  tttcctggg  tacagtgca  tgccatttt  gaaaaatac  gtaattctt  780
tgtatccat  tgcacctct  attctgctc  acgggcttt  cctggcact  ggatggaac  840
tcacccata  tctctgttc  ttctataag  acagagtga  ataaaaagt  agaagaaga  900
tcaatcgta  ctgtgtcaa  agtattgtg  agtgatcat  tcttgtaaa  cttgtaaat  960
aactatcat  tttgtagat  tcttaaagg  gtaaagttt  caaatttga  gaaatatat  1020
ttaacactg  ggtcaggta  attccttaa  actaattaa  tgtacattt  tataataaa  1080
attttttaa  ctaa  1094



<210> 6488
<211> 259
<212> PRT
<213> Homo sapiens
<308> AAD27771
<400> 6488

Met Leu Pro Ser Thr Ser Val Asn Ser Leu Val Gln Gly Asn Gly Val 
  1               5                  10                  15
Leu Asn Ser Arg Asp Ala Ala Arg His Thr Ala Gly Ala Lys Arg Tyr 
             20                  25                  30
Lys Tyr Leu Arg Arg Leu Phe Arg Phe Arg Gln Met Asp Phe Glu Phe 
         35                  40                  45
Ala Ala Trp Gln Met Leu Tyr Leu Phe Thr Ser Pro Gln Arg Val Tyr 
     50                  55                  60
Arg Asn Phe His Tyr Arg Lys Gln Thr Lys Asp Gln Trp Ala Arg Asp 
 65                  70                  75                  80
Asp Pro Ala Phe Leu Val Leu Leu Ser Ile Trp Leu Cys Val Ser Thr 
                 85                  90                  95
Ile Gly Phe Gly Phe Val Leu Asp Met Gly Phe Phe Glu Thr Ile Lys 
             100                105                110
Leu Leu Leu Trp Val Val Leu Ile Asp Cys Val Gly Val Gly Leu Leu 
         115                120                125
Ile Ala Thr Leu Met Trp Phe Ile Ser Asn Lys Tyr Leu Val Lys Arg 
     130                135                140
Gln Ser Arg Asp Tyr Asp Val Glu Trp Gly Tyr Ala Phe Asp Val His 
 145                150                155                160
Leu Asn Ala Phe Tyr Pro Leu Leu Val Ile Leu His Phe Ile Gln Leu 
                 165                170                175
Phe Phe Ile Asn His Val Ile Leu Thr Asp Thr Phe Ile Gly Tyr Leu 
             180                185                190
Val Gly Asn Thr Leu Trp Leu Val Ala Val Gly Tyr Tyr Ile Tyr Val 
         195                200                205
Thr Phe Leu Gly Tyr Ser Ala Leu Pro Phe Leu Lys Asn Thr Val Ile 
     210                215                220
Leu Leu Tyr Pro Phe Ala Pro Leu Ile Leu Leu Tyr Gly Leu Ser Leu 
 225                230                235                240
Ala Leu Gly Trp Asn Phe Thr His Thr Leu Cys Ser Phe Tyr Lys Tyr 
                 245                250                255
Arg Val Lys 
             260



<210> 6489
<211> 607
<212> DNA
<213> Rattus norvegicus
<308> AI008638
<400> 6489

ccagtggag  gcacaaatg  attttggaa  ctgcttgtt  acttgggta  caagccagc  60
gaggtccca  agccagctc  ccaaccacc  agagcccat  tatctctcc  gacccgaca  120
tcctcttgt  aaccgaggc  ccagagcga  ggtcaagag  ggtctcagg  gataagagg  180
aggatctgg  gacccaagg  gcagcaagc  gacgtgggc  tctccttcc  ggaatggaa  240
atggaggga  gtgcggtgt  cagagacgg  tgggcaacc  gaggttccc  ttagtcttg  300
gtcaacccc  ggagaaagt  taggacttg  ggtggttgg  acagcagcc  acatacccc  360
acttcactc  tcttctcta  tcatctcag  cctgtccaa  tcccccaga  tgcctgaga  420
aaggggcta  caggaggcc  gtgggggct  cagggtgag  ggaagggtg  ggggcaact  480
tgaaacccc  ttgcccttc  tgcctgtag  cccagtgca  tcaagaggg  ggattgaga  540
ggtgtcagc  acagaaggc  gcatggcct  ggaggcagg  ccaggaggc  cctcagcct  600
tggccgt  607



<210> 6490
<211> 427
<212> PRT
<213> Rattus norvegicus
<308> P70490
<400> 6490

Met Gln Phe Ser Arg Val Leu Ala Ala Leu Cys Gly Val Leu Leu Cys 
  1               5                  10                  15
Ala Ser Gly Leu Phe Ala Ala Ser Gly Asp Phe Cys Asp Ser Ser Leu 
             20                  25                  30
Cys Leu Asn Gly Gly Thr Cys Leu Met Gly Gln Asp Asn Asp Ile Tyr 
         35                  40                  45
Cys Leu Cys Pro Glu Gly Phe Thr Gly Leu Val Cys Asn Glu Thr Glu 
     50                  55                  60
Lys Gly Pro Cys Ser Pro Asn Pro Cys Phe His Asp Ala Lys Cys Leu 
 65                  70                  75                  80
Val Thr Glu Asp Thr Gln Arg Gly Asp Ile Phe Thr Glu Tyr Ile Cys 
                 85                  90                  95
Gln Cys Pro Val Gly Tyr Ser Gly Ile His Cys Glu Leu Gly Cys Ser 
             100                105                110
Thr Lys Leu Gly Leu Glu Gly Gly Ala Ile Ala Asp Ser Gln Ile Ser 
         115                120                125
Ala Ser Ser Val Tyr Met Gly Phe Met Gly Leu Gln Arg Trp Gly Pro 
     130                135                140
Glu Leu Ala Arg Leu Tyr Arg Thr Gly Ile Val Asn Ala Trp Thr Ala 
 145                150                155                160
Ser Ser Tyr Asp Ser Lys Pro Trp Ile Gln Val Asp Phe Leu Arg Lys 
                 165                170                175
Met Arg Val Ser Gly Val Met Thr Gln Gly Ala Ser Arg Ala Gly Arg 
             180                185                190
Ala Glu Tyr Leu Lys Thr Phe Lys Val Ala Tyr Ser Leu Asp Gly Arg 
         195                200                205
Arg Phe Glu Phe Ile Gln Asp Glu Ser Gly Thr Gly Asp Lys Glu Phe 
     210                215                220
Met Gly Asn Gln Asp Asn Asn Ser Leu Lys Ile Asn Met Phe Asn Pro 
 225                230                235                240
Thr Leu Glu Ala Gln Tyr Ile Arg Leu Tyr Pro Val Ser Cys His Arg 
                 245                250                255
Gly Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu His Gly Cys 
             260                265                270
Ser Glu Pro Leu Gly Leu Lys Asn Asn Thr Ile Pro Asp Ser Gln Ile 
         275                280                285
Thr Ala Ser Ser Ser Tyr Lys Thr Trp Asn Leu Arg Ala Phe Gly Trp 
     290                295                300
Tyr Pro His Leu Gly Arg Leu Asp Asn Gln Gly Lys Ile Asn Ala Trp 
 305                310                315                320
Thr Ala Gln Ser Asn Ser Ala Lys Glu Trp Leu Gln Val Asp Leu Gly 
                 325                330                335
Thr Gln Lys Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asp Phe 
             340                345                350
Gly His Ile Gln Tyr Val Ala Ser Tyr Lys Val Ala His Ser Asp Asp 
         355                360                365
Gly Val Gln Trp Thr Val Tyr Glu Glu Gln Gly Thr Ser Lys Val Phe 
     370                375                380
Gln Gly Asn Leu Asp Asn Asn Ser His Lys Lys Asn Ile Phe Glu Lys 
 385                390                395                400
Pro Phe Met Ala Arg Tyr Val Arg Val Leu Pro Leu Ser Trp His Asn 
                 405                410                415
Arg Ile Thr Leu Arg Leu Glu Leu Leu Gly Cys 
             420                425



<210> 6491
<211> 1934
<212> DNA
<213> Homo sapiens
<308> U58516
<400> 6491

agaaccccg  ggggtctga  cagcccagc  tgcccattc  agcgcccgc  tccccgcag  60
atgccgcgc  cccgcctgc  ggccgcgct  tgcggcgcg  tgctctgcg  ccccagcct  120
ctcgtcgcc  tggatatct  ttccaaaaa  ccctgccac  acggtggtt  atgcgagga  180
atttcccaa  aagtgcgag  agatgtctt  ccctcgtac  cctgcacgt  ccttaaggg  240
tacgcgggc  accactgtg  gacgaaatg  gtcgagcca  tgggcatgg  gaatgggaa  300
attgccaac  cacagatcg  cgcctcatc  gtgcgtgtg  ccttcttgg  tttgcagca  360
tgggtcccg  agctggccc  cctgaaccg  gcaggcatg  tcaatgcct  gacacccag  420
agcaatgac  ataacccct  gatccaggt  aacctgctg  ggaggatgt  ggtaacagg  480
gtggtgacg  agggtgcca  ccgcttggc  agtcatgag  acctgaagg  cttcaaggt  540
gcctacagc  ttaatggac  cgaattcga  ttcatccat  atgttaata  aaaacacaa  600
gagtttgtg  gtaactgga  caaaaacgc  gtgcatgtc  acctgtttg  gacccctgt  660
gaggctcag  acgtgagat  gtaccccac  agctgccac  cggcctgca  tctgcgctt  720
gagctactg  gctgtgagc  gaacggatg  gccaatccc  tgggcctga  gaataacag  780
atccctgac  agcagatca  ggcctccag  agctacaag  cctggggct  gcatctctt  840
agctggaac  cctcctatg  acggctgga  aagcagggc  acttcaacg  ctgggttgc  900
gggagctac  gtaacgatc  gtggctgca  gtggacctg  gctcctcga  ggaggtgac  960
ggcatcatc  cccaggggg  ccgtaactt  ggctctgtc  agtttgtgg  atcctacaa  1020
gttgcctac  gtaatgaca  tgcgaactg  actgagtac  aggacccca  gactggcag  1080
agtaagatc  tccctggca  ctgggacaa  cactcccac  agaagaact  gtttgagac  1140
cccatcctg  ctcgctatg  gcgcatcct  cctgtagcc  ggcacaacc  catcgccct  1200
cgcctggag  tgctgggct  ttagtggcc  cctgccacc  ccaggtctt  ctgctttcc  1260
tgggcccgc  gcctcttgg  ttctcagcc  ctttaaatc  ccatagggc  ggggactgg  1320
gaaggggag  gtgttcaga  gcagcacca  cacacagtc  cccctccct  cctctttcc  1380
accctccac  tctcacggg  cctgcccca  cccctaagc  ccgtcccct  acccccagt  1440
ctcactgtc  tgttttctt  ggcactgag  gatctgagt  ggtctggga  ggacaggaa  1500
gggcaaagt  gggcgtgtg  tttccctgc  cctgtccgg  ccgccgatc  caggtgcgt  1560
tgtctctgt  tctcctagc  cctctctca  acatcacat  cccatggtg  cctcaagaa  1620
ggcccggaa  ccccaggct  gagataaca  cctcttgcc  gtcggccct  cgtcggccc  1680
ggggtacca  gtgccacaa  tgctgtggc  ccctgtccc  aagacactt  cccttgtct  1740
cctggttgc  tctcttgcc  cttgtcctg  agcccagcg  cacagaagg  ggtggggcg  1800
gtctatggg  agaaaggga  cgaggtcag  ggagccggc  tgggttggc  gggtgggcg  1860
ttggggccc  catgctggc  tttcacccc  gaggacaca  gcagcttcc  aaatatatt  1920
atcttcttc  cggg  1934



<210> 6492
<211> 387
<212> PRT
<213> Homo sapiens
<308> Q08431
<400> 6492

Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 
  1               5                  10                  15
Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 
             20                  25                  30
His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 
         35                  40                  45
Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 
     50                  55                  60
His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 
 65                  70                  75                  80
Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 
                 85                  90                  95
Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 
             100                105                110
Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 
         115                120                125
Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 
     130                135                140
Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 
 145                150                155                160
Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 
                 165                170                175
Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 
             180                185                190
Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 
         195                200                205
Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 
     210                215                220
Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 
 225                230                235                240
Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 
                 245                250                255
Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 
             260                265                270
Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 
         275                280                285
Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 
     290                295                300
Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 
 305                310                315                320
Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 
                 325                330                335
Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 
             340                345                350
His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 
         355                360                365
Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 
     370                375                380
Leu Gly Cys 
 385



<210> 6493
<211> 496
<212> DNA
<213> Rattus norvegicus
<308> AI008639
<400> 6493

cgctacaga  aataaaaac  caaaaaata  ccaactcta  acatgatcc  taatgtaca  60
gggaaagtc  tggtagagt  tgaaggaaa  ccagagctg  ccaatacaa  tggctgttg  120
ctgtcagtt  gtagaaggt  tcttgccac  gagattgga  tcaaaagtg  aaaaggaaa  180
cattttaaa  accaaacct  gaattcaac  tcgtatatg  actcagttt  attcactct  240
gtaactagg  aaaaagtat  catgtctgt  gtacagtca  tgcgtccca  gcttctact  300
caacgtcta  aaagtcacc  ccaagggat  aatgatggc  aacgaaggg  ttaggataa  360
caaaaggta  aaaaaagtt  gcagtcttg  cccaagata  aaaaactga  ttttaaaca  420
tgtcaaaac  tacatgatt  aaacagtat  tgaaaaaaa  tcacacatc  aatcaagta  480
aaaaatatc  aaacta  496



<210> 6494
<211> 552
<212> PRT
<213> Rattus norvegicus
<308> O70437
<400> 6494

Met Asp Asn Met Ser Ile Thr Asn Thr Pro Thr Ser Asn Asp Ala Cys 
  1               5                  10                  15
Leu Ser Ile Val His Ser Leu Met Cys His Arg Gln Gly Gly Glu Ser 
             20                  25                  30
Glu Thr Phe Ala Lys Arg Ala Ile Glu Ser Leu Val Lys Lys Leu Lys 
         35                  40                  45
Glu Lys Lys Asp Glu Leu Asp Ser Leu Ile Thr Ala Ile Thr Thr Asn 
     50                  55                  60
Gly Ala His Pro Ser Lys Cys Val Thr Ile Gln Arg Thr Leu Asp Gly 
 65                  70                  75                  80
Arg Leu Gln Val Ala Gly Arg Lys Gly Phe Pro His Val Ile Tyr Ala 
                 85                  90                  95
Arg Leu Trp Arg Trp Pro Asp Leu His Lys Asn Glu Leu Lys His Val 
             100                105                110
Lys Tyr Cys Gln Tyr Ala Phe Asp Leu Lys Cys Asp Ser Val Cys Val 
         115                120                125
Asn Pro Tyr His Tyr Glu Arg Val Val Ser Pro Gly Ile Asp Leu Ser 
     130                135                140
Gly Leu Thr Leu Gln Ser Asn Ala Pro Pro Ser Met Leu Val Lys Asp 
 145                150                155                160
Glu Tyr Val His Asp Phe Glu Gly Gln Pro Ser Leu Pro Thr Glu Gly 
                 165                170                175
His Ser Ile Gln Thr Ile Gln His Pro Pro Ser Asn Arg Ala Ser Thr 
             180                185                190
Glu Thr Tyr Ser Ala Pro Ala Leu Leu Ala Pro Ser Glu Ser Asn Ala 
         195                200                205
Thr Ser Thr Thr Asn Phe Pro Asn Ile Pro Val Ala Ser Thr Ser Gln 
     210                215                220
Pro Ala Ser Ile Leu Ala Gly Ser His Ser Glu Gly Leu Leu Gln Ile 
 225                230                235                240
Ala Ser Gly Pro Gln Pro Gly Gln Gln Gln Asn Gly Phe Thr Ala Gln 
                 245                250                255
Pro Ala Thr Tyr His His Asn Ser Thr Thr Thr Trp Thr Gly Ser Arg 
             260                265                270
Thr Ala Pro Tyr Thr Pro Asn Leu Pro His His Gln Asn Gly His Leu 
         275                280                285
Gln His His Pro Pro Met Pro Pro His Pro Gly His Tyr Trp Pro Val 
     290                295                300
His Asn Glu Leu Ala Phe Gln Pro Pro Ile Ser Asn His Pro Ala Pro 
 305                310                315                320
Glu Tyr Trp Cys Ser Ile Ala Tyr Phe Glu Met Asp Val Gln Val Gly 
                 325                330                335
Glu Thr Phe Lys Val Pro Ser Ser Cys Pro Ile Val Thr Val Asp Gly 
             340                345                350
Tyr Val Asp Pro Ser Gly Gly Asp Arg Phe Cys Leu Gly Gln Leu Ser 
         355                360                365
Asn Val His Arg Thr Glu Ala Ile Glu Arg Ala Arg Leu His Ile Gly 
     370                375                380
Lys Gly Val Gln Leu Glu Cys Lys Gly Glu Gly Asp Val Trp Val Arg 
 385                390                395                400
Cys Leu Ser Asp His Ala Val Phe Val Gln Ser Tyr Tyr Leu Asp Arg 
                 405                410                415
Glu Ala Gly Arg Ala Pro Gly Asp Ala Val His Lys Ile Tyr Pro Ser 
             420                425                430
Ala Tyr Ile Lys Val Phe Asp Leu Arg Gln Cys His Arg Gln Met Gln 
         435                440                445
Gln Gln Ala Ala Thr Ala Gln Ala Ala Ala Ala Ala Gln Ala Ala Ala 
     450                455                460
Val Ala Gly Asn Ile Pro Gly Pro Gly Ser Val Gly Gly Ile Ala Pro 
 465                470                475                480
Ala Ile Ser Leu Ser Ala Ala Ala Gly Ile Gly Val Asp Asp Leu Arg 
                 485                490                495
Arg Leu Cys Ile Leu Arg Met Ser Phe Val Lys Gly Trp Gly Pro Asp 
             500                505                510
Tyr Pro Arg Gln Ser Ile Lys Glu Thr Pro Cys Trp Ile Glu Ile His 
         515                520                525
Leu His Arg Ala Leu Gln Leu Leu Asp Glu Val Leu His Thr Met Pro 
     530                535                540
Ile Ala Asp Pro Gln Pro Leu Asp 
 545                550



<210> 6495
<211> 308
<212> DNA
<213> Homo sapiens
<308> N74105
<400> 6495

agttggctt  ctcttttaa  caaaaacat  ctttgttac  gagttctca  gaaaggttc  60
actattttt  agccacaga  tttaaccag  caaaagtat  cagaaagcc  caaaggaac  120
cctgggact  tcaactgac  agttgtccc  aaagcagaa  ctacgagtg  ctcttctct  180
gcttctggc  tagctgcat  cctctgaat  taggggagg  aacagttgg  aaataccac  240
accaaatct  tccccaacc  ccaactcac  tcttctaaa  tgggctctg  agcccacca  300
gttttcat  308



<210> 6496
<211> 460
<212> DNA
<213> Rattus norvegicus
<308> AI008836
<400> 6496

gagcctgtt  gcctaccag  acccttctt  cctacttca  ttttgccct  ggcacggta  60
gcagcaata  ccttttcat  cttctcctt  agtttagct  ctttctgct  atacggttg  120
ttatctttg  cagattgct  agaccacat  tcccccagt  tctttgcag  atctccaat  180
gacaggccg  ggtgttcac  tttgatctt  gggcgatgt  cagagcaaa  caggaagaa  240
gcagacggt  gtctcttgg  agcatttgg  tcttttttc  ttcctttct  atcaccttg  300
ggaaggaag  ctctctgtg  aggtctgag  gaagagctc  cgccaggta  acgctgcgc  360
gtcatcatg  gcaaggggg  ccccaacaa  ccgcggggc  agatgtcct  gtacgcctt  420
ttcgtgcaa  cctgccggg  ggagcacag  aagaagcatt  460



<210> 6497
<211> 209
<212> PRT
<213> Rattus norvegicus
<308> P52925
<400> 6497

Gly Lys Gly Asp Pro Asn Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
  1               5                  10                  15
Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
             20                  25                  30
Ser Ser Val Asn Phe Ala Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
         35                  40                  45
Lys Thr Met Ser Ala Lys Glu Lys Ser Lys Phe Glu Asp Leu Ala Lys 
     50                  55                  60
Ser Asp Lys Ala Arg Tyr Asp Arg Glu Met Lys Asn Tyr Val Pro Pro 
 65                  70                  75                  80
Lys Gly Asp Lys Lys Gly Lys Lys Lys Asp Pro Asn Ala Pro Lys Arg 
                 85                  90                  95
Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu His Arg Pro Lys Ile 
             100                105                110
Lys Ser Glu His Pro Gly Leu Ser Ile Gly Asp Thr Ala Lys Lys Leu 
         115                120                125
Gly Glu Met Trp Ser Glu Gln Ser Ala Lys Asp Lys Gln Pro Tyr Glu 
     130                135                140
Gln Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
 145                150                155                160
Tyr Arg Ala Lys Gly Lys Ser Glu Val Gly Lys Lys Gly Pro Gly Arg 
                 165                170                175
Pro Thr Gly Ser Lys Lys Lys Asn Glu Pro Glu Asp Glu Glu Glu Glu 
             180                185                190
Glu Glu Glu Glu Asp Asp Glu Asp Glu Glu Glu Glu Asp Glu Asp Glu 
         195                200                205
Glu 
     210



<210> 6498
<211> 1066
<212> DNA
<213> Homo sapiens
<308> Z17240
<400> 6498

cgggaagag  acaagaaga  acacccgga  tcttccgtc  atttcgcgg  attctccaa  60
aagtgttcg  agagatgga  gaccatgtc  gcaaaggag  agtcgaagt  tgaagatat  120
gcaaaaagt  acaaagctc  ctatgacag  gagatgaaa  attacgttc  tcccaaagg  180
gataagaag  ggaagaaaa  ggaccccaa  gctcctaaa  ggccaccat  tgccttctt  240
ctgttttgc  ctgaacatc  cccaaagat  aaaagtgaa  accctggcc  atccattgg  300
gatactgca  agaaattgg  tgaaatgtg  tctgagcag  cagccaaag  taaacaacc  360
tatgaacag  aagcagcta  gctaaagga  aaatatgaa  aggatattg  tgcatatgg  420
gccaagggc  aaagtgaag  aggaaagaa  ggccctggc  ggccaacag  ctcaaagaa  480
aagaacgaa  cagaagatg  ggaggagga  gaggaagaa  aagatgaag  tgaggagga  540
gaggatgaa  atgaagaat  aatggctat  ctttaatga  gcgtgtgga  tgtgtgtgt  600
tgctcaggc  attattttg  taagaatgt  aattcaagt  cagctcaat  ctagcttca  660
tataaaaac  gtacagatt  ttgtatagc  gataagatt  tctgtagag  aaatacttt  720
aaaaaatgc  ggttgtagc  ttttgatgg  ctactcata  agttagatt  tacagcttc  780
gatgttgaa  gttcctaaa  atttaatgg  ttttttaat  tcttgtgta  ggtagcaca  840
caaacttgt  ggatttagt  tcaatagta  attttgggt  ttttaggat  ttgcatttc  900
tttttttaa  aaaaatttt  taataaaat  atgtatatt  aaagcaggg  gcagaatgt  960
aaagaagct  ctatttgac  ccttgtatt  tcctagtga  agcggaggt  tttactggt  1020
aaaaatata  ggaatgggc  gggagcagt  gctcacacc  gaattc  1066



<210> 6499
<211> 208
<212> PRT
<213> Homo sapiens
<308> P26583
<400> 6499

Gly Lys Gly Asp Pro Asn Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
  1               5                  10                  15
Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
             20                  25                  30
Ser Ser Val Asn Phe Ala Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
         35                  40                  45
Lys Thr Met Ser Ala Lys Glu Lys Ser Lys Phe Glu Asp Met Ala Lys 
     50                  55                  60
Ser Asp Lys Ala Arg Tyr Asp Arg Glu Met Lys Asn Tyr Val Pro Pro 
 65                  70                  75                  80
Lys Gly Asp Lys Lys Gly Lys Lys Lys Asp Pro Asn Ala Pro Lys Arg 
                 85                  90                  95
Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu His Arg Pro Lys Ile 
             100                105                110
Lys Ser Glu His Pro Gly Leu Ser Ile Gly Asp Thr Ala Lys Lys Leu 
         115                120                125
Gly Glu Met Trp Ser Glu Gln Ser Ala Lys Asp Lys Gln Pro Tyr Glu 
     130                135                140
Gln Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
 145                150                155                160
Tyr Arg Ala Lys Gly Lys Ser Glu Ala Gly Lys Lys Gly Pro Gly Arg 
                 165                170                175
Pro Thr Gly Ser Lys Lys Lys Asn Glu Pro Glu Asp Glu Glu Glu Glu 
             180                185                190
Glu Glu Glu Glu Asp Glu Asp Glu Glu Glu Glu Asp Glu Asp Glu Glu 
         195                200                205



<210> 6500
<211> 531
<212> DNA
<213> Rattus norvegicus
<308> AI008852
<400> 6500

cgcaacggg  ttgccgtca  aacgcaggt  ttgtgaaag  caccgctaa  tcaaagcaa  60
aatgggaaa  gaaaagact  acatcaaca  cgtcgtaat  ggacacgta  attccggca  120
gtccaccac  accggccac  tgatctaca  atgtggtgg  atcgacaaa  gaaccattg  180
aaagtttga  aaggaggct  cggagatgg  aaaaggctc  ttcaagtat  cctgggtcc  240
ggacaaact  aaagctgag  gtgagcgtg  tatcactat  gacatctcc  tgtggaagt  300
tgagaccag  aagtactat  tgactatca  tgatgcccc  ggacacaga  acttcatca  360
gaacatgat  acgggcaca  ctcaggctg  ctgcgctgt  ctgattgtt  ctgctggtg  420
tggggaatt  gaagctggt  tctccaaga  cgggcagac  cgtgagcat  ctcttctgg  480
tacactttg  gtgtgaaac  acttaattg  ggtgtcaac  aaatggatt  c  531



<210> 6501
<211> 462
<212> PRT
<213> Rattus norvegicus
<308> P20001
<400> 6501

Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val 
  1               5                  10                  15
Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Gly 
             20                  25                  30
Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu 
         35                  40                  45
Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys 
     50                  55                  60
Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe 
 65                  70                  75                  80
Glu Thr Ser Lys Tyr Tyr Val Thr Ile Ile Asp Ala Pro Gly His Arg 
                 85                  90                  95
Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala 
             100                105                110
Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser 
         115                120                125
Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly 
     130                135                140
Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro 
 145                150                155                160
Pro Tyr Ser Gln Lys Arg Tyr Glu Glu Ile Val Lys Glu Val Ser Thr 
                 165                170                175
Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Asp Thr Val Ala Phe Val Pro 
             180                185                190
Ile Ser Gly Trp Asn Gly Asp Asn Met Leu Glu Pro Ser Ala Asn Met 
         195                200                205
Pro Trp Phe Lys Gly Trp Lys Val Thr Arg Lys Asp Gly Ser Ala Ser 
     210                215                220
Gly Thr Thr Leu Leu Glu Ala Leu Asp Cys Ile Leu Pro Pro Thr Arg 
 225                230                235                240
Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile 
                 245                250                255
Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Val Leu 
             260                265                270
Lys Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Val Thr Thr Glu 
         275                280                285
Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro 
     290                295                300
Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Val 
 305                310                315                320
Arg Arg Gly Asn Val Ala Gly Asp Ser Lys Asn Asp Pro Pro Met Glu 
                 325                330                335
Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln 
             340                345                350
Ile Ser Ala Gly Tyr Ala Pro Val Leu Asp Cys His Thr Ala His Ile 
         355                360                365
Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly 
     370                375                380
Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys Ser Gly Asp Ala Ala 
 385                390                395                400
Ile Val Asp Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser 
                 405                410                415
Asp Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg Gln Thr 
             420                425                430
Val Ala Val Gly Val Ile Lys Ala Val Asp Lys Lys Ala Ala Gly Ala 
         435                440                445
Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Lys 
     450                455                460



<210> 6502
<211> 436
<212> DNA
<213> Homo sapiens
<308> AA076035
<400> 6502

aattctgtg  cagattttt  gtcaagttg  ttccattaa  aagtactga  tttgaaaac  60
aataactta  aactgccac  cacaaaaaa  atggtccac  acattcttt  cttctgaag  120
ttttacgat  cattgttat  attaaccag  cttttacta  taaacttaa  tggccaatt  180
agacaaaca  ttctgagac  gttcttcca  cactgatta  gactggggt  gcaggtgtt  240
aggggtaat  ttcatttag  cttctgagc  ttctgggca  actttggtg  ctttgccag  300
tccagcaag  cttcttggt  cacagcttt  atggacacc  acagccaac  ggtctggcc  360
catgtcacg  acagcaaag  nacccaagt  gaggggtag  cagagaagc  ctccacaca  420
atggggctg  caggaa  436



<210> 6503
<211> 462
<212> PRT
<213> Homo sapiens
<308> P04720
<400> 6503

Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val 
  1               5                  10                  15
Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Gly 
             20                  25                  30
Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu 
         35                  40                  45
Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys 
     50                  55                  60
Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe 
 65                  70                  75                  80
Glu Thr Ser Lys Tyr Tyr Val Thr Ile Ile Asp Ala Pro Gly His Arg 
                 85                  90                  95
Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala 
             100                105                110
Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser 
         115                120                125
Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly 
     130                135                140
Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro 
 145                150                155                160
Pro Tyr Ser Gln Lys Arg Tyr Glu Glu Ile Val Lys Glu Val Ser Thr 
                 165                170                175
Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Asp Thr Val Ala Phe Val Pro 
             180                185                190
Ile Ser Gly Trp Asn Gly Asp Asn Met Leu Glu Pro Ser Ala Asn Met 
         195                200                205
Pro Trp Phe Lys Gly Trp Lys Val Thr Arg Lys Asp Gly Asn Ala Ser 
     210                215                220
Gly Thr Thr Leu Leu Glu Ala Leu Asp Cys Ile Leu Pro Pro Thr Arg 
 225                230                235                240
Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile 
                 245                250                255
Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Val Leu 
             260                265                270
Lys Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Val Thr Thr Glu 
         275                280                285
Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro 
     290                295                300
Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Val 
 305                310                315                320
Arg Arg Gly Asn Val Ala Gly Asp Ser Lys Asn Asp Pro Pro Met Glu 
                 325                330                335
Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln 
             340                345                350
Ile Ser Ala Gly Tyr Ala Pro Val Leu Asp Cys His Thr Ala His Ile 
         355                360                365
Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly 
     370                375                380
Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys Ser Gly Asp Ala Ala 
 385                390                395                400
Ile Val Asp Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser 
                 405                410                415
Asp Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg Gln Thr 
             420                425                430
Val Ala Val Gly Val Ile Lys Ala Val Asp Lys Lys Ala Ala Gly Ala 
         435                440                445
Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Lys 
     450                455                460



<210> 6504
<211> 440
<212> DNA
<213> Rattus norvegicus
<308> AI008888
<400> 6504

acggtctct  aaaatatat  tttagagag  tagttttat  cagttttct  aaaataatt  60
tttggaaag  aacaaaata  aacgccgtt  gggcatcac  aaggaagct  ctcacagag  120
ggtatttac  tcgtggtcc  aaacacgga  tccaaaggt  aagtatttg  caaaggggc  180
gcagaatca  aagtaggtt  gctcatcgt  cttttcttt  tcggtctgg  aagaggaca  240
ggtcaaagg  ttgttctca  gagggaggg  ttcaaacac  ctcaagtgc  cacattttt  300
ttcgccgac  tcaaccttg  tgaagaagt  ggtgccggc  actacctgt  tcctgaagg  360
tatggcttt  aagacatca  acttctgat  tgctttctc  tcaagttga  acttcacct  420
gttggcgat  tcctgcgtct  440



<210> 6505
<211> 98
<212> PRT
<213> Rattus norvegicus
<308> P01041
<400> 6505

Met Met Cys Gly Ala Pro Ser Ala Thr Met Pro Ala Thr Thr Glu Thr 
  1               5                  10                  15
Gln Glu Ile Ala Asp Lys Val Lys Ser Gln Leu Glu Glu Lys Ala Asn 
             20                  25                  30
Gln Lys Phe Asp Val Phe Lys Ala Ile Ser Phe Arg Arg Gln Val Val 
         35                  40                  45
Ala Gly Thr Asn Phe Phe Ile Lys Val Asp Val Gly Glu Glu Lys Cys 
     50                  55                  60
Val His Leu Arg Val Phe Glu Pro Leu Pro His Glu Asn Lys Pro Leu 
 65                  70                  75                  80
Thr Leu Ser Ser Tyr Gln Thr Asp Lys Glu Lys His Asp Glu Leu Thr 
                 85                  90                  95
Tyr Phe 
             100



<210> 6506
<211> 338
<212> DNA
<213> Homo sapiens
<308> AW451145
<400> 6506

ttttttttt  tttttttaa  gcccctaaa  atatatatt  agagagatc  tatacagtt  60
tctgaaaat  attatttgg  aggatgcaa  atacaacgc  gtttgagaa  cacaacaga  120
gctgctcaa  tcccttctc  ccatcaccg  ggggggttt  actacgtgg  cccaaacac  180
ggtgcaaag  agccccgaa  cagaagtag  agagctcat  gtgcctttc  ttgttggtc  240
gataggaag  cagggtcaa  ggcttgttt  catggggga  gggttgaaa  accctcaag  300
gcacgcatt  atctccacc  acatcaacc  tgatgaag  338



<210> 6507
<211> 98
<212> PRT
<213> Homo sapiens
<308> P04080
<400> 6507

Met Met Cys Gly Ala Pro Ser Ala Thr Gln Pro Ala Thr Ala Glu Thr 
  1               5                  10                  15
Gln His Ile Ala Asp Gln Val Arg Ser Gln Leu Glu Glu Lys Glu Asn 
             20                  25                  30
Lys Lys Phe Pro Val Phe Lys Ala Val Ser Phe Lys Ser Gln Val Val 
         35                  40                  45
Ala Gly Thr Asn Tyr Phe Ile Lys Val His Val Gly Asp Glu Asp Phe 
     50                  55                  60
Val His Leu Arg Val Phe Gln Ser Leu Pro His Glu Asn Lys Pro Leu 
 65                  70                  75                  80
Thr Leu Ser Asn Tyr Gln Thr Asn Lys Ala Lys His Asp Glu Leu Thr 
                 85                  90                  95
Tyr Phe 
             100



<210> 6508
<211> 440
<212> DNA
<213> Rattus norvegicus
<308> AI008888
<400> 6508

acggtctct  aaaatatat  tttagagag  tagttttat  cagttttct  aaaataatt  60
tttggaaag  aacaaaata  aacgccgtt  gggcatcac  aaggaagct  ctcacagag  120
ggtatttac  tcgtggtcc  aaacacgga  tccaaaggt  aagtatttg  caaaggggc  180
gcagaatca  aagtaggtt  gctcatcgt  cttttcttt  tcggtctgg  aagaggaca  240
ggtcaaagg  ttgttctca  gagggaggg  ttcaaacac  ctcaagtgc  cacattttt  300
ttcgccgac  tcaaccttg  tgaagaagt  ggtgccggc  actacctgt  tcctgaagg  360
tatggcttt  aagacatca  acttctgat  tgctttctc  tcaagttga  acttcacct  420
gttggcgat  tcctgcgtct  440



<210> 6509
<211> 98
<212> PRT
<213> Rattus norvegicus
<308> P01041
<400> 6509

Met Met Cys Gly Ala Pro Ser Ala Thr Met Pro Ala Thr Thr Glu Thr 
  1               5                  10                  15
Gln Glu Ile Ala Asp Lys Val Lys Ser Gln Leu Glu Glu Lys Ala Asn 
             20                  25                  30
Gln Lys Phe Asp Val Phe Lys Ala Ile Ser Phe Arg Arg Gln Val Val 
         35                  40                  45
Ala Gly Thr Asn Phe Phe Ile Lys Val Asp Val Gly Glu Glu Lys Cys 
     50                  55                  60
Val His Leu Arg Val Phe Glu Pro Leu Pro His Glu Asn Lys Pro Leu 
 65                  70                  75                  80
Thr Leu Ser Ser Tyr Gln Thr Asp Lys Glu Lys His Asp Glu Leu Thr 
                 85                  90                  95
Tyr Phe 
             100



<210> 6510
<211> 338
<212> DNA
<213> Homo sapiens
<308> AW451145
<400> 6510

ttttttttt  tttttttaa  gcccctaaa  atatatatt  agagagatc  tatacagtt  60
tctgaaaat  attatttgg  aggatgcaa  atacaacgc  gtttgagaa  cacaacaga  120
gctgctcaa  tcccttctc  ccatcaccg  ggggggttt  actacgtgg  cccaaacac  180
ggtgcaaag  agccccgaa  cagaagtag  agagctcat  gtgcctttc  ttgttggtc  240
gataggaag  cagggtcaa  ggcttgttt  catggggga  gggttgaaa  accctcaag  300
gcacgcatt  atctccacc  acatcaacc  tgatgaag  338



<210> 6511
<211> 98
<212> PRT
<213> Homo sapiens
<308> P04080
<400> 6511

Met Met Cys Gly Ala Pro Ser Ala Thr Gln Pro Ala Thr Ala Glu Thr 
  1               5                  10                  15
Gln His Ile Ala Asp Gln Val Arg Ser Gln Leu Glu Glu Lys Glu Asn 
             20                  25                  30
Lys Lys Phe Pro Val Phe Lys Ala Val Ser Phe Lys Ser Gln Val Val 
         35                  40                  45
Ala Gly Thr Asn Tyr Phe Ile Lys Val His Val Gly Asp Glu Asp Phe 
     50                  55                  60
Val His Leu Arg Val Phe Gln Ser Leu Pro His Glu Asn Lys Pro Leu 
 65                  70                  75                  80
Thr Leu Ser Asn Tyr Gln Thr Asn Lys Ala Lys His Asp Glu Leu Thr 
                 85                  90                  95
Tyr Phe 
             100



<210> 6512
<211> 320
<212> DNA
<213> Rattus norvegicus
<308> AI009141
<400> 6512

cagctttga  ccctgaaac  gcttgtggc  ggttcagtt  ctgacagca  aaattccat  60
gagtctatt  aaggattga  tgacttcac  agccctggt  tcaggagat  aactttcat  120
ttggggtag  ggttcactt  agaatacaa  atcttcaga  taactgatg  ccaaaatac  180
gtcttaaat  atgagatcc  tcaattttt  gtattgtct  gacctgcaa  tagaattac  240
ttgtaaaat  tttttcagc  tgtgttaag  tgtatgtga  atttttttg  ttaagtgta  300
acttcatac  atactgtcag  320



<210> 6513
<211> 634
<212> DNA
<213> Homo sapiens
<308> AW978356
<400> 6513

aagcttgcg  acgctcatt  cggccgctc  ttttttttt  ttgagacgg  gtctaactc  60
tttgctcag  ccggactgc  gtggcgcta  ctctgctca  tggaacctc  gcctcctgg  120
ttcacgcca  tctcctgcc  cagcctccc  aatggctgg  actacaggc  cctgccact  180
cacccggct  attttttgt  tttttagta  agatgaggt  tcgccatgt  ggctaggct  240
gtcttgagc  cttgacctc  gatgatcgg  ctgcctcgg  ttcccaaag  gttagaatt  300
caggcgtga  ccaccatgc  cggatgtat  aatggtatt  taataataa  tcttggttg  360
taaacttaa  catgacagt  ttgagcagg  accttaagt  ctgtatact  ccgtgaggc  420
aggcacttg  ttagcttct  tgtcataca  ctacccctt  tattttgtt  ttttttttt  480
tagtataat  aatctatag  tttattaac  caaaaactg  tagtgtggt  tgagggtta  540
gtttaaaca  agttttcac  gaaatctaa  acatgccta  aaagatttt  caatctagc  600
ctagatgca  gtcccgaca  tatcaagaa  tgat  634



<210> 6514
<211> 351
<212> DNA
<213> Rattus norvegicus
<308> AI009147
<400> 6514

gcctaacga  tgacaactg  cggcttgtt  agcttaggg  tccttgaag  ggccgggcc  60
gagagtgag  ccccagtcc  aggctgggg  tctttccaa  tagaggaaa  ggatcccga  120
gggctacag  ccaaaattg  tgagaacca  acatatgat  agcgtctag  gattaacga  180
tcggaagag  ttgccagta  tagcactcc  accccagga  atcaaggcc  tcctttttc  240
gccgctctt  ccagcaagg  gatggctga  aacagcagt  atgagtacg  ggaggacaa  300
aaggagaag  agaagccct  acagctgac  cctcagcaa  gcttcagtg  g  351



<210> 6515
<211> 1663
<212> DNA
<213> Homo sapiens
<308> AJ249980
<400> 6515

acgaggcgc  ggtgaggct  aacgcgcag  aggtctcac  agagtggaa  caactctcg  60
gaattttaa  atttatctt  ttgcctagc  actgacaac  ggctggttg  ttggcgtgg  120
atcctaaag  ggcctggct  tgagactgg  gtgagaccc  agccctagg  ggtacattt  180
cattataga  gagacggat  cagaagggc  acagaccaa  gttgttgaa  accagacat  240
tgatgagcg  ctagagatt  acgactccg  agaggttgc  agtatttat  ctccaaccc  300
aagacacca  ggacttcct  gttctgccc  tcttcctaa  aaggctatg  ctgataaca  360
cagtgatga  tgtgaagag  aaaataaca  ggagaagaa  aagacctca  agttgacac  420
tcaacgggg  tttagtgaa  atgaggatg  cgatgatga  gatgatgat  catctgaaa  480
tgattctga  tctgatgat  atgatgaag  gcatggagc  cctctggaa  gggcctatg  540
ccctgcaga  tatgagcat  tgccagttt  tgctgaaat  aaggaactc  tccagtaca  600
cagtaggta  acacctcag  tgattgacc  ggaccacaa  ctgaagcct  tcattcctg  660
ttttatccc  gctgtcggg  atattgatg  attcttaaa  gtcccacgt  ctgatggaa  720
gcctgacaa  cttggccta  tggtattgg  tgaaccttc  acaaagcag  cagacccta  780
ggtgctctc  ctctggtta  cagagaatt  taagcagca  aacatcaca  aacatatga  840
agtaaaaag  ctagaagat  cagaaaaga  tcccaaagc  attgacacg  ggattgaga  900
catctctga  ttacaccgt  ctaagcccc  tgcgactgt  cactacacc  ggcccatgc  960
cgacattga  acgctgatg  aggaatggt  cccggagtt  gaagagctt  tgggcaagg  1020
aagcctgcc  acggcagag  ttgattgca  cctggcaga  tacattgac  tgatctgtg  1080
cattctaga  atccctgtc  acaagagtc  gatccagtc  ctccatctg  tcttttccc  1140
ctactcaga  ttcaagaac  cacagcatt  taaagctct  gctgaaggc  agaaagcat  1200
cactccttc  tccaattcc  cctcccaag  tggagacat  gagacatta  ccttcagct  1260
agacacttc  caagctgct  tttcaaggc  gagctggcc  ctctgcccc  gctgagatg  1320
acagatcgt  gtcagctac  tgatgtcct  gcccatgcc  cagcttggc  caggggcag  1380
gcatgtcct  ctgccctct  tgccagagg  cacagaaca  gtttgttta  tgaacctgc  1440
tgcctcaga  tgctgtccc  ggggagtta  tgcatctac  ccactgtgg  gatttgagt  1500
ataagaatt  gaatttctg  gatcccatg  aggttagat  gggaggaaa  cttaaaaga  1560
gtccttttt  tgagaggga  ggaattgtt  tctttcatt  gtaaagtta  tgagtaaag  1620
ttttataaa  caaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaa  1663



<210> 6516
<211> 304
<212> PRT
<213> Homo sapiens
<308> CAB96537
<400> 6516

Met Ala Asp Asn Ser Ser Asp Glu Cys Glu Glu Glu Asn Asn Lys Glu 
  1               5                  10                  15
Lys Lys Lys Thr Ser Gln Leu Thr Pro Gln Arg Gly Phe Ser Glu Asn 
             20                  25                  30
Glu Asp Asp Asp Asp Asp Asp Asp Asp Ser Ser Glu Thr Asp Ser Asp 
         35                  40                  45
Ser Asp Asp Asp Asp Glu Glu His Gly Ala Pro Leu Glu Gly Ala Tyr 
     50                  55                  60
Asp Pro Ala Asp Tyr Glu His Leu Pro Val Ser Ala Glu Ile Lys Glu 
 65                  70                  75                  80
Leu Phe Gln Tyr Ile Ser Arg Tyr Thr Pro Gln Leu Ile Asp Leu Asp 
                 85                  90                  95
His Lys Leu Lys Pro Phe Ile Pro Asp Phe Ile Pro Ala Val Gly Asp 
             100                105                110
Ile Asp Ala Phe Leu Lys Val Pro Arg Pro Asp Gly Lys Pro Asp Asn 
         115                120                125
Leu Gly Leu Leu Val Leu Asp Glu Pro Ser Thr Lys Gln Ser Asp Pro 
     130                135                140
Thr Val Leu Ser Leu Trp Leu Thr Glu Asn Ser Lys Gln His Asn Ile 
 145                150                155                160
Thr Gln His Met Lys Val Lys Ser Leu Glu Asp Ala Glu Lys Asn Pro 
                 165                170                175
Lys Ala Ile Asp Thr Trp Ile Glu Ser Ile Ser Glu Leu His Arg Ser 
             180                185                190
Lys Pro Pro Ala Thr Val His Tyr Thr Arg Pro Met Pro Asp Ile Asp 
         195                200                205
Thr Leu Met Gln Glu Trp Ser Pro Glu Phe Glu Glu Leu Leu Gly Lys 
     210                215                220
Val Ser Leu Pro Thr Ala Glu Ile Asp Cys Ser Leu Ala Glu Tyr Ile 
 225                230                235                240
Asp Met Ile Cys Ala Ile Leu Asp Ile Pro Val Tyr Lys Ser Arg Ile 
                 245                250                255
Gln Ser Leu His Leu Leu Phe Ser Leu Tyr Ser Glu Phe Lys Asn Ser 
             260                265                270
Gln His Phe Lys Ala Leu Ala Glu Gly Lys Lys Ala Phe Thr Pro Ser 
         275                280                285
Ser Asn Ser Thr Ser Gln Ala Gly Asp Met Glu Thr Leu Thr Phe Ser 
     290                295                300



<210> 6517
<211> 382
<212> DNA
<213> Rattus norvegicus
<308> AI009268
<400> 6517

atatatata  atatgcctt  agttcctgg  gtgatcctg  tagaaatga  tggatgcct  60
ttctctgaa  gtgttggtg  tggataaat  gatggctat  tgagccaag  cctgggtga  120
tgtaggagc  agaatcgtt  gctgttcta  catcaaagc  atgttgatt  gggtcgagc  180
ctgtatact  gaaaaattc  catcatttt  tagtttgat  gctttcaga  aggcacagt  240
ctggtgaat  cttggcact  atcttggtt  ttctttcct  aatctgtgt  ctgttttca  300
tatatacta  ttgctcctt  cctttgtat  tgttttctt  tcccactct  ttctttatc  360
ttctctctc  caccctcgt  cc  382



<210> 6518
<211> 533
<212> PRT
<213> Rattus norvegicus
<308> P15791
<400> 6518

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
  1               5                  10                  15
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
             20                  25                  30
Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
         115                120                125
Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
             180                185                190
Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
 305                310                315                320
Leu Lys Lys Pro Asp Gly Val Lys Ile Asn Asn Lys Ala Asn Val Val 
                 325                330                335
Thr Ser Pro Lys Glu Asn Ile Pro Thr Pro Ala Leu Glu Pro Gln Thr 
             340                345                350
Thr Val Ile His Asn Pro Asp Gly Asn Lys Glu Ser Thr Glu Ser Ser 
         355                360                365
Asn Thr Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile 
     370                375                380
Ile Lys Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe 
 385                390                395                400
Glu Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro 
                 405                410                415
Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr 
             420                425                430
Phe Glu Asn Ala Leu Pro Lys Ile Asn Lys Pro Ile His Thr Ile Ile 
         435                440                445
Leu Asn Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala 
     450                455                460
Tyr Ile Arg Leu Thr Gln Tyr Met Asp Gly Asn Gly Met Pro Lys Thr 
 465                470                475                480
Met Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp 
                 485                490                495
Gln Asn Ile His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys 
             500                505                510
Pro Pro Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser 
         515                520                525
Leu Trp Gln Asn Ile 
     530



<210> 6520
<211> 499
<212> PRT
<213> Homo sapiens
<308> Q13557
<400> 6520

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
  1               5                  10                  15
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
             20                  25                  30
Lys Ile Pro Thr Gly Gln Gly Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
         115                120                125
Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
             180                185                190
Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
 305                310                315                320
Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr 
                 325                330                335
Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys 
             340                345                350
Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala 
         355                360                365
Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala 
     370                375                380
Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
 385                390                395                400
Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn 
                 405                410                415
Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile 
             420                425                430
Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln 
         435                440                445
Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
     450                455                460
Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys Pro Pro 
 465                470                475                480
Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser Leu Trp 
                 485                490                495
Gln Asn Ile 
             500



<210> 6521
<211> 472
<212> DNA
<213> Rattus norvegicus
<308> AI009390
<400> 6521

acatacttg  tgaaggtgc  tcccttaaa  attctctcc  gcggaaaac  gagcatgga  60
agcagcttc  agctgctct  ctcagggcc  gggctcctc  ttgcccaaa  ggtgaggcg  120
aggggtgta  ttcccctct  tcatcagct  ctcccgctg  ttcttgatt  catgcatcc  180
ccttatcgt  ttgaaccga  gaaagcatt  ttcaaagtc  tcatactct  tcttgcact  240
ttttttagc  cgggtagca  cgatcccat  tgcgcattc  atccactcc  tttcaaatg  300
gtggcatcg  gcggcattc  tgtaaggct  ctcagcact  aggaatata  agtgtcgat  360
taggctaat  cccagcctt  tctgcacat  aaggaaagg  atgacttct  ggctgaccg  420
acacagcaa  cgcctaccg  acctcagca  tgcccttct  aagtccctg  gc  472



<210> 6522
<211> 106
<212> PRT
<213> Rattus norvegicus
<308> AAH02163
<400> 6522

Met Pro Phe Leu Asp Ile Gln Lys Lys Leu Gly Ile Ser Leu Asp Arg 
  1               5                  10                  15
His Phe Met Phe Leu Ser Ala Glu Gln Pro Tyr Lys Asn Ala Ala Arg 
             20                  25                  30
Cys His Ala Phe Glu Lys Glu Trp Ile Glu Cys Ala His Gly Ile Gly 
         35                  40                  45
Gly Thr Arg Ala Lys Lys Glu Cys Lys Ile Glu Phe Asp Asp Phe Glu 
     50                  55                  60
Glu Cys Leu Leu Arg Tyr Lys Thr Met Arg Arg Met His Asp Ile Lys 
 65                  70                  75                  80
Lys Gln Arg Glu Lys Leu Met Lys Glu Gly Lys Tyr Thr Pro Pro Pro 
                 85                  90                  95
His His Ser Gly Arg Glu Glu Pro Arg Pro 
             100                105



<210> 6523
<211> 510
<212> DNA
<213> Homo sapiens
<308> AF020352
<400> 6523

accaatctg  agtgggagc  gcggccaga  aagagtcaa  ggcacgagc  tcgggtagc  60
atgcctttc  tggacatcc  gaaaaggtt  ggccttaac  tagatcgat  gttgacaat  120
cagagtggt  aacagccct  caagatggc  ggtcgatgc  atgcttttg  aaaagaatg  180
atagaatgt  cacatggaa  cggttatac  cgggcagag  aagagtgca  gatagaata  240
gatgatttc  tagagtgtt  gcttcggca  aaaacgatg  gacgtgcag  taccatcag  300
aagcagcgg  ataagctga  aaaggaagg  aagtacacc  ctccacctc  ccacattgg  360
aagggggag  ctcggccct  aacagagca  ctgctgatg  ctggaggct  attttcctg  420
tctctgttc  ccactggaa  ggttgttta  gacaaacct  cttgtcaaa  tgtgtaaaa  480
taaaggatt  ctccatcct  aaaaaaaaaa  510



<210> 6524
<211> 105
<212> PRT
<213> Homo sapiens
<308> O43920
<400> 6524

Pro Phe Leu Asp Ile Gln Lys Arg Phe Gly Leu Asn Ile Asp Arg Trp 
  1               5                  10                  15
Leu Thr Ile Gln Ser Gly Glu Gln Pro Tyr Lys Met Ala Gly Arg Cys 
             20                  25                  30
His Ala Phe Glu Lys Glu Trp Ile Glu Cys Ala His Gly Ile Gly Tyr 
         35                  40                  45
Thr Arg Ala Glu Lys Glu Cys Lys Ile Glu Tyr Asp Asp Phe Val Glu 
     50                  55                  60
Cys Leu Leu Arg Gln Lys Thr Met Arg Arg Ala Gly Thr Ile Arg Lys 
 65                  70                  75                  80
Gln Arg Asp Lys Leu Ile Lys Glu Gly Lys Tyr Thr Pro Pro Pro His 
                 85                  90                  95
His Ile Gly Lys Gly Glu Pro Arg Pro 
             100                105



<210> 6525
<211> 501
<212> DNA
<213> Rattus norvegicus
<308> AI009405
<400> 6525

cagttcacc  caaaagaga  agagagaga  agagagaga  agagagaga  agagagaga  60
agagagaga  atataaatc  aggtatagc  agctgctga  cacgttgtt  gcagtcttt  120
gtgcaaaat  aggcgtatt  gagctccac  ttaagtggc  cagcggtat  tactggctc  180
gcacgctga  gcaatgcac  tcgtctttc  ccttggtgt  atagcctgg  aatggctgc  240
cgtacttgt  cacgcacca  cagaagccc  gctttctgc  tttggaagg  cgacactgt  300
tcttcttat  gaacccctt  ttgtcacag  ttgggatgt  gacgcccct  ggactcagc  360
cattgagga  cttcagatg  ttcagtgtg  cctccattt  tctgcggca  ggaccatat  420
ctgtctccc  cttagactc  gaggagaag  tctgggtgt  tgtgctctg  gactcatag  480
caactttgt  gcgctggct  t  501



<210> 6526
<211> 292
<212> PRT
<213> Rattus norvegicus
<308> P15473
<400> 6526

Met His Pro Ala Arg Pro Ala Leu Trp Ala Ala Ala Leu Thr Ala Leu 
  1               5                  10                  15
Thr Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Gly Ala Val 
             20                  25                  30
Gly Ala Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu 
         35                  40                  45
Ala Gln Cys Ala Pro Pro Pro Thr Ala Pro Ala Cys Thr Glu Leu Val 
     50                  55                  60
Arg Glu Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Arg Glu Gly 
 65                  70                  75                  80
Asp Ala Cys Gly Val Tyr Thr Glu Arg Cys Gly Thr Gly Leu Arg Cys 
                 85                  90                  95
Gln Pro Arg Pro Ala Glu Gln Tyr Pro Leu Lys Ala Leu Leu Asn Gly 
             100                105                110
Arg Gly Phe Cys Ala Asn Ala Ser Ala Ala Ser Asn Leu Ser Ala Tyr 
         115                120                125
Leu Pro Ser Gln Pro Ser Pro Gly Asn Thr Thr Glu Ser Glu Glu Asp 
     130                135                140
His Asn Ala Gly Ser Val Glu Ser Gln Val Val Pro Ser Thr His Arg 
 145                150                155                160
Val Thr Asp Ser Lys Phe His Pro Leu His Ser Lys Met Glu Val Ile 
                 165                170                175
Ile Lys Gly Gln Ala Arg Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu 
             180                185                190
Ser Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu 
         195                200                205
Thr Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His 
     210                215                220
Leu Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn 
 225                230                235                240
Cys Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys 
                 245                250                255
Gly Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro 
             260                265                270
Leu Pro Gly Tyr Asp Thr Lys Gly Lys Asp Asp Val His Cys Leu Ser 
         275                280                285
Val Gln Ser Gln 
     290



<210> 6527
<211> 242
<212> DNA
<213> Homo sapiens
<308> BF196063
<400> 6527

tttcctact  agccaagga  tacttcttt  ttccgaaga  aactgttcg  tattgatct  60
agcgattcc  tttgctgcc  tgtagcctc  agtgtttgc  catgaccat  ctcataatc  120
gttttgtat  aatggtttt  aacattcag  gaataattg  ttctaatat  aaatgcagt  180
tatactatt  atagtttta  cgataagtg  aatatttta  ataatttta  caattaaat  240
tg  242



<210> 6528
<211> 558
<212> DNA
<213> Rattus norvegicus
<308> AI009801
<400> 6528

ggtctcaaa  catttattt  tcccgaccg  aaggtggcc  tcattacgg  tggataaac  60
cagaacggg  cgtgcagca  gactcgaag  acagcggtg  aggtaagtg  ggcccgggc  120
caagcgaag  tggaaccgt  ccagcccac  ttggctgcg  tcatgtcgt  atagttgat  180
tagacccgg  ccgggctga  gtgcaggcg  tcggacagc  ggccgcaca  cagcttgct  240
tagttgcgg  tctgggcgc  accgatctt  ccgatgctg  gcaggctgc  gagggcgca  300
gggtcgctc  tgccgctaa  agtcatgag  tggtccggg  ccacgtgca  tgcgatgta  360
tgtgccggc  tgccggtgg  ctgcgccag  tgctgggtg  gctcggaga  aaacccctc  420
ggcacggag  cgcggggaa  attggtgtt  acgatgaac  taggcatgg  ggcggagag  480
ctgcgagcg  cggccggag  acggtgtaa  gcgcggtgt  acccaagtc  gggacctga  540
ctacgtgac  cagctcag  558



<210> 6529
<211> 114
<212> PRT
<213> Rattus norvegicus
<308> P30904
<400> 6529

Pro Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro Glu 
  1               5                  10                  15
Gly Phe Leu Ser Glu Leu Thr Gln Gln Leu Ala Gln Ala Thr Gly Lys 
             20                  25                  30
Pro Ala Gln Tyr Ile Ala Val His Val Val Pro Asp Gln Leu Met Thr 
         35                  40                  45
Phe Ser Gly Thr Ser Asp Pro Cys Ala Leu Cys Ser Leu His Ser Ile 
     50                  55                  60
Gly Lys Ile Gly Gly Ala Gln Asn Arg Asn Tyr Ser Lys Leu Leu Cys 
 65                  70                  75                  80
Gly Leu Leu Ser Asp Arg Leu His Ile Ser Pro Asp Arg Val Tyr Ile 
                 85                  90                  95
Asn Tyr Tyr Asp Met Asn Ala Ala Asn Val Gly Trp Asn Gly Ser Thr 
             100                105                110
Phe Ala 
         115



<210> 6530
<211> 561
<212> DNA
<213> Homo sapiens
<308> NM_002415
<400> 6530

accacagtg  tgtccgaga  gtcaggcac  tagctcagc  gcggccgcg  cgcgtgcgt  60
tgtgcctct  cgcgggtct  ctggtcctt  tgccatcat  ccgatgttc  tcgtaaaca  120
caacgtgcc  cgcgcctcc  tgccggacg  gttcctctc  gagctcacc  agcagctgg  180
gcaggccac  ggcaagccc  cccagtaca  cgcggtgca  gtggtcccg  accagctca  240
ggccttcgg  ggctccagc  agccgtgcg  gctctgcag  ctgcacagc  tcggcaaga  300
cggcggcgc  cagaaccgc  cctacagca  gctgctgtg  ggcctgctg  ccgagcgcc  360
gcgcatcag  ccggacagg  tctacatca  ctattacga  atgaacgcg  ccaatgtgg  420
ctggaacaa  tccaccttc  cctaagagc  gcagggacc  acgctgtct  cgctggctc  480
acccgggaa  ccgccgcac  ctgtgttct  ggcccgccc  ccccaacct  ctggtgggg  540
gaaataaac  gtttagaga  t  561



<210> 6531
<211> 114
<212> PRT
<213> Homo sapiens
<308> P14174
<400> 6531

Pro Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro Asp 
  1               5                  10                  15
Gly Phe Leu Ser Glu Leu Thr Gln Gln Leu Ala Gln Ala Thr Gly Lys 
             20                  25                  30
Pro Pro Gln Tyr Ile Ala Val His Val Val Pro Asp Gln Leu Met Ala 
         35                  40                  45
Phe Gly Gly Ser Ser Glu Pro Cys Ala Leu Cys Ser Leu His Ser Ile 
     50                  55                  60
Gly Lys Ile Gly Gly Ala Gln Asn Arg Ser Tyr Ser Lys Leu Leu Cys 
 65                  70                  75                  80
Gly Leu Leu Ala Glu Arg Leu Arg Ile Ser Pro Asp Arg Val Tyr Ile 
                 85                  90                  95
Asn Tyr Tyr Asp Met Asn Ala Ala Asn Val Gly Trp Asn Asn Ser Thr 
             100                105                110
Phe Ala 
         115



<210> 6532
<211> 376
<212> DNA
<213> Rattus norvegicus
<308> AI010293
<400> 6532

gccaggaaa  tccgacttt  atttcttaa  tactgtgaa  gaagggggg  aatggtccc  60
tggtgagaa  gctaggggt  atcagcaaa  gcccggtgg  cattaggga  gcgctgggg  120
ctgtagttg  gatcttcct  cagtcgttt  tgaatatca  accggagct  ctgcctgta  180
ctctcctga  cctctggtg  ctccaggtc  cggctcagg  tctcggggc  tgtcagggg  240
cgagctccg  ctgccttag  tgcccggct  actgcctct  agagtagca  ctgggggcc  300
tcaccctgc  ttgtctttc  tctcttggc  ggcatgcca  tgaggtagg  atcactcaa  360
ggcggctga  gtttca  376



<210> 6533
<211> 3702
<212> DNA
<213> Homo sapiens
<308> BC003133
<400> 6533

ctcctcggg  tgctcggct  cctcccacc  aggccggcc  cggcccgac  cgccctcag  60
aactcactg  ttggggctg  ggactttct  gtcgtgccc  acaaaagta  agcttgggg  120
cctgggggg  gccggaagt  tcgcttcga  atccccaaa  actatcggg  aaacggaag  180
ggccgtcgg  ggcagagac  tgtcggcca  ggagcctaa  gatagtacc  gtaccgctg  240
ggaggagcc  gacagcttg  aggtgttgg  gaagacctt  gactctcaa  ctcgtacct  300
tattgtggg  gcccagatg  atgtaaaag  gtttaagga  cacattgct  cctctgtca  360
catcccatc  gaaaaacaa  ggctcattt  ccagggacg  gttctgcaa  atgataaga  420
gcttcagga  tacaatgtt  ggggaaagg  tatccacct  gtggaacgg  ctcctcctc  480
gactcacct  ccttctggg  catcttctg  gacggggtc  gcctcagcc  ctcatggtg  540
gggatcccc  cctggtact  gggggcctg  ggcctctgt  catgaccgg  atgccaaca  600
ctatgtcat  gttggaacc  tcaatcttc  tagtgacgg  tctgctgtg  atgttcaca  660
caacatgga  caggccccg  ttcagagtg  gccccgggt  cggctggtg  tggctcagc  720
catgatcag  gatatacag  ccttactat  ccggatgga  tgtcgagga  ggccccaac  780
gcagcacag  cagccgccc  cgcagccac  ggctgtgac  ccggagcca  tagccttga  840
ctctcaaac  tcagaacca  ttgaaagtg  agcacctcc  cgggagccc  tggaggcag  900
agaagtgga  gagcgtgcc  cagcccaga  cccggagct  actcctggc  cagccccag  960
gggcccaac  cctgccccg  aaacaaatg  acccaacca  ccttcccct  cggagtatg  1020
cgaggtgct  caggagcta  agcggctgg  gagtcgcct  cagcccttc  tgcagcgct  1080
ctacgaggt  ctgggtgct  ctgccacca  ggactacaa  aacaatcac  agggccggg  1140
ggaggatca  cggttgatc  acttggtag  ggagagcct  cgactgctg  gcaacacct  1200
tgttgcact  tctgacctg  gctgcaatc  ggcctgcac  cccccacga  acctgcatg  1260
ggtccggcc  atgtctcac  acaccaccc  catggtgct  cagcaggca  ccattccca  1320
acagatcaa  gtgggaacc  ctgtgacca  gacaggaaa  gggactcgg  cccccccaa  1380
tcccaatgc  gaggcacct  cccctggtc  tgggcaggc  tcatccgtg  ctccgtctt  1440
taccaatgt  gagtcctca  ctgaggggg  tcccccgcc  ggtccagct  ccccgccag  1500
caccagcca  ccgagggtc  tccggattt  ccaccagag  gtggaaccc  tggtcatga  1560
gcacatgaa  attcaagat  ctggcacac  gcctggtgg  gttccgagt  ctcccactg  1620
ccccctggg  ccccctggt  atggccaaa  cctgggaca  caggtgcca  gcttcccaa  1680
agctccaac  cgggtggtg  ttgcccggc  cactcctcc  caggctcgg  cttcccatc  1740
tggagggcc  ccagtctct  ggacactgc  gggcgccgg  ctgggtacc  atgcctcgt  1800
ggcccagat  gtgagcggc  ttgtggggc  gcttcttat  cagccagtc  ttgtggctc  1860
ggggacccc  ggtatggct  caccgccag  ccctgccac  gcttctgcc  gtgctggca  1920
caccaacac  gctaccaca  ctggccccg  tcctggggg  cctgcccag  ctccaccca  1980
ccctcaacc  tccatggct  atcttcagt  ctctcagct  ctggggaac  tgctagggc  2040
tgcagggcc  ggggctgga  ggtctggtg  ggcttctcc  accatcact  tggcgatgc  2100
tggtgtccc  gcctttctc  aaggcatga  tgacttctt  caggcaaca  agacagccc  2160
tccaccacc  ccacctcct  cacccccac  acctgcccc  gagcagcag  ccatgcccc  2220
accaggctc  ccttctggt  gcgcaggga  tcctggagg  ctgggtctt  agagcctgt  2280
accggagtt  tttacctca  tggtgcagg  tgtgctcag  tccctgctg  gctccctgg  2340
ggctcgggc  ggcagcagt  aaagtattg  tgccttcat  caacgcctc  gtggatcca  2400
caacatctt  gagcctgga  ctgatgggg  ccttggatt  tttggggcc  tgctttctc  2460
tctgtgcca  aacttctct  tggtggacg  agtgatgct  ctccatggg  atttccagc  2520
actacaacg  ctccagccc  agctgcgat  cttcttcca  cagcactac  tgggtggtc  2580
ggagcccac  cccagtaac  tccggatgg  aacccacac  ttgatcacg  ggctagaag  2640
gtatgtgcg  gagagtttt  ccttggtgc  ggttcagcc  ggtgtggac  tcatccgga  2700
aaacctgga  tttctccaa  agcagttta  tagcattgc  gcgcatgtg  tgcattgca  2760
agatagtgg  tttggggcc  ggttgctgg  gttgtgtaa  caaggcctg  ttgaatgcc  2820
ggccctaaa  ctgcactgc  tggggggac  gcagatgga  cttgctgct  ttatcaatg  2880
ccgaattcg  cgtatgtct  gtggggtga  tccctcctt  gtgagctgg  tgaccacta  2940
gatgggact  aggcttcag  tggtactgg  gcacatgcc  gtaggccct  atgccattc  3000
cagatacgt  cgcagggtt  gtgatcccc  ccagccact  cctgaggag  caatggaag  3060
tcagggagc  gaaagagct  cccctgagc  tcagcggga  aatgcttcc  cagcccctg  3120
aacaacagc  gaagaggcc  tgtcccgag  tccacctcc  gctcctgag  ggggctccc  3180
ggatgaaca  gatggagct  cagctgaga  agaaccttg  gcagctgca  tccccccag  3240
atgggtccc  attatccag  aggacattc  gagccagcg  aaggtgaaa  cgcagcccc  3300
tctgagtga  gcctacctc  gtggtatgc  tgccaagag  cgcaagacg  tgcagggtg  3360
gggccccca  ctgcttctc  cagaggctg  gagccgggc  gctaaggca  ccggagctc  3420
gcccctgac  agccccgag  gcctgagcc  ggacctgga  gcaccagag  ttcaggaga  3480
ctacaggca  cagctccgg  ctgatatac  aaaacgact  caggaagac  ccaactaca  3540
tccccagcg  ttccccaat  cccagcggg  ctttgctga  gatccttag  tctttgctc  3600
atggccctt  ctcatcagg  gaccgtttc  cccctcttc  ttcacagta  ttaagaaat  3660
aaagtcgga  ttttctggc  aaaaaaaaa  aaaaaaaaa  aa  3702



<210> 6534
<211> 1132
<212> PRT
<213> Homo sapiens
<308> P46379
<400> 6534

Met Glu Pro Asn Asp Ser Thr Ser Thr Ala Val Glu Glu Pro Asp Ser 
  1               5                  10                  15
Leu Glu Val Leu Val Lys Thr Leu Asp Ser Gln Thr Arg Thr Phe Ile 
             20                  25                  30
Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Arg Ala 
         35                  40                  45
Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
     50                  55                  60
Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
 65                  70                  75                  80
Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Thr His Leu Pro Ser 
                 85                  90                  95
Gly Ala Ser Ser Gly Thr Gly Ser Ala Ser Ala Thr His Gly Gly Gly 
             100                105                110
Ser Pro Pro Gly Thr Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
         115                120                125
Ala Asn Ser Tyr Val Met Val Gly Thr Phe Asn Leu Pro Ser Asp Gly 
     130                135                140
Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
 145                150                155                160
Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                 165                170                175
Gln Thr Leu Leu Ser Arg Met Glu Thr Leu Pro Tyr Leu Gln Cys Arg 
             180                185                190
Gly Gly Pro Gln Pro Gln His Ser Gln Pro Pro Pro Gln Pro Pro Ala 
         195                200                205
Val Thr Pro Glu Pro Val Ala Leu Ser Ser Gln Thr Ser Glu Pro Val 
     210                215                220
Glu Ser Glu Ala Pro Pro Arg Glu Pro Met Glu Ala Glu Glu Val Glu 
 225                230                235                240
Glu Arg Ala Pro Ala Gln Asn Pro Glu Leu Thr Pro Gly Pro Ala Pro 
                 245                250                255
Ala Gly Pro Thr Pro Ala Pro Glu Thr Asn Ala Pro Asn His Pro Ser 
             260                265                270
Pro Ala Glu Tyr Val Glu Val Leu Gln Glu Leu Gln Arg Leu Glu Ser 
         275                280                285
Arg Leu Gln Pro Phe Leu Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala 
     290                295                300
Ala Thr Thr Asp Tyr Asn Asn Asn His Glu Gly Arg Glu Glu Asp Gln 
 305                310                315                320
Arg Leu Ile Asn Leu Val Gly Glu Ser Leu Arg Leu Leu Gly Asn Thr 
                 325                330                335
Phe Val Ala Leu Ser Asp Leu Arg Cys Asn Leu Ala Cys Thr Pro Pro 
             340                345                350
Arg His Leu His Val Val Arg Pro Met Ser His Tyr Thr Thr Pro Met 
         355                360                365
Val Leu Gln Gln Ala Ala Ile Pro Ile Gln Ile Asn Val Gly Thr Thr 
     370                375                380
Val Thr Met Thr Gly Asn Gly Thr Arg Pro Pro Pro Thr Pro Asn Ala 
 385                390                395                400
Glu Ala Pro Pro Pro Gly Pro Gly Gln Ala Ser Ser Val Ala Pro Ser 
                 405                410                415
Ser Thr Asn Val Glu Ser Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro 
             420                425                430
Ala Pro Pro Pro Ala Thr Ser His Pro Arg Val Ile Arg Ile Ser His 
         435                440                445
Gln Ser Val Glu Pro Val Val Met Met His Met Asn Ile Gln Asp Ser 
     450                455                460
Gly Thr Gln Pro Gly Gly Val Pro Ser Ala Pro Thr Gly Pro Leu Gly 
 465                470                475                480
Pro Pro Gly His Gly Gln Thr Leu Gly Gln Gln Val Pro Gly Phe Pro 
                 485                490                495
Thr Ala Pro Thr Arg Val Val Ile Ala Arg Pro Thr Pro Pro Gln Ala 
             500                505                510
Arg Pro Ser His Pro Gly Gly Pro Pro Val Ser Gly Thr Leu Gln Gly 
         515                520                525
Ala Gly Leu Gly Thr Asn Ala Ser Leu Ala Gln Met Val Ser Gly Leu 
     530                535                540
Val Gly Gln Leu Leu Met Gln Pro Val Leu Val Ala Gln Gly Thr Pro 
 545                550                555                560
Gly Met Ala Pro Pro Pro Ala Pro Ala Thr Ala Ser Ala Ser Ala Gly 
                 565                570                575
Thr Thr Asn Thr Ala Thr Thr Ala Gly Pro Ala Pro Gly Gly Pro Ala 
             580                585                590
Gln Pro Pro Pro Thr Pro Gln Pro Ser Met Ala Asp Leu Gln Phe Ser 
         595                600                605
Gln Leu Leu Gly Asn Leu Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly 
     610                615                620
Pro Gly Val Ala Ser Pro Thr Ile Thr Val Ala Met Pro Gly Val Pro 
 625                630                635                640
Ala Phe Leu Gln Gly Met Thr Asp Phe Leu Gln Ala Thr Gln Thr Ala 
                 645                650                655
Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln 
             660                665                670
Gln Thr Met Pro Pro Pro Gly Ser Pro Ser Gly Gly Ala Gly Ser Pro 
         675                680                685
Gly Gly Leu Gly Leu Glu Ser Leu Ser Pro Glu Phe Phe Thr Ser Val 
     690                695                700
Val Gln Gly Val Leu Ser Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala 
 705                710                715                720
Gly Ser Ser Glu Ser Ile Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser 
                 725                730                735
Ser Asn Ile Phe Glu Pro Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly 
             740                745                750
Ala Leu Leu Ser Leu Leu Cys Gln Asn Phe Ser Met Val Asp Val Val 
         755                760                765
Met Leu Leu His Gly His Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln 
     770                775                780
Leu Arg Ser Phe Phe His Gln His Tyr Leu Gly Gly Gln Glu Pro Thr 
 785                790                795                800
Pro Ser Asn Ile Arg Met Ala Thr His Thr Leu Ile Thr Gly Leu Glu 
                 805                810                815
Glu Tyr Val Arg Glu Ser Phe Ser Leu Val Gln Val Gln Pro Gly Val 
             820                825                830
Asp Ile Ile Arg Thr Asn Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser 
         835                840                845
Ile Ala Ala His Val Leu His Cys Thr Asp Ser Gly Phe Gly Ala Arg 
     850                855                860
Leu Leu Glu Leu Cys Asn Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn 
 865                870                875                880
Leu His Cys Leu Gly Gly Gln Gln Met Glu Leu Ala Ala Val Ile Asn 
                 885                890                895
Gly Arg Ile Arg Arg Met Ser Arg Gly Val Asn Pro Ser Leu Val Ser 
             900                905                910
Trp Leu Thr Thr Met Met Gly Leu Arg Leu Gln Val Val Leu Glu His 
         915                920                925
Met Pro Val Gly Pro Asp Ala Ile Leu Arg Tyr Val Arg Arg Val Gly 
     930                935                940
Asp Pro Pro Gln Pro Leu Pro Glu Glu Pro Met Glu Val Gln Gly Ala 
 945                950                955                960
Glu Arg Ala Ser Pro Glu Pro Gln Arg Glu Asn Ala Ser Pro Ala Pro 
                 965                970                975
Gly Thr Thr Ala Glu Glu Ala Met Ser Arg Gly Pro Pro Pro Ala Pro 
             980                985                990
Glu Gly Gly Ser Arg Asp Glu Gln Asp Gly Ala Ser Ala Glu Thr Glu 
         995                1000                1005
Pro Trp Ala Ala Ala Val Pro Pro Glu Trp Val Pro Ile Ile Gln Gln 
     1010                1015                1020
Asp Ile Gln Ser Gln Arg Lys Val Lys Pro Gln Pro Pro Leu Ser Asp 
 1025                1030                1035                1040
Ala Tyr Leu Ser Gly Met Pro Ala Lys Arg Arg Lys Thr Met Gln Gly 
                 1045                1050                1055
Glu Gly Pro Gln Leu Leu Leu Ser Glu Ala Val Ser Arg Ala Ala Lys 
             1060                1065                1070
Ala Ala Gly Ala Arg Pro Leu Thr Ser Pro Glu Ser Leu Ser Arg Asp 
         1075                1080                1085
Leu Glu Ala Pro Glu Val Gln Glu Ser Tyr Arg Gln Gln Leu Arg Ser 
     1090                1095                1100
Asp Ile Gln Lys Arg Leu Gln Glu Asp Pro Asn Tyr Ser Pro Gln Arg 
 1105                1110                1115                1120
Phe Pro Asn Ala Gln Arg Ala Phe Ala Asp Asp Pro 
                 1125                1130



<210> 6535
<211> 376
<212> DNA
<213> Rattus norvegicus
<308> AI010293
<400> 6535

gccaggaaa  tccgacttt  atttcttaa  tactgtgaa  gaagggggg  aatggtccc  60
tggtgagaa  gctaggggt  atcagcaaa  gcccggtgg  cattaggga  gcgctgggg  120
ctgtagttg  gatcttcct  cagtcgttt  tgaatatca  accggagct  ctgcctgta  180
ctctcctga  cctctggtg  ctccaggtc  cggctcagg  tctcggggc  tgtcagggg  240
cgagctccg  ctgccttag  tgcccggct  actgcctct  agagtagca  ctgggggcc  300
tcaccctgc  ttgtctttc  tctcttggc  ggcatgcca  tgaggtagg  atcactcaa  360
ggcggctga  gtttca  376



<210> 6536
<211> 1098
<212> PRT
<213> Rattus norvegicus
<308> BAA76607
<400> 6536

Met Glu Pro Asn Asp Ser Thr Ser Thr Ala Val Glu Glu Pro Asp Ser 
  1               5                  10                  15
Leu Glu Val Leu Val Lys Thr Leu Asp Ser Gln Thr Arg Thr Phe Ile 
             20                  25                  30
Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Arg Ala 
         35                  40                  45
Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
     50                  55                  60
Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
 65                  70                  75                  80
Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Thr His Leu Pro Ser 
                 85                  90                  95
Gly Ala Ser Ser Gly Thr Gly Ser Ala Ser Ala Thr His Gly Gly Gly 
             100                105                110
Pro Cys Pro Gly Thr Arg Gly Pro Gly Ala Ser Gly His Asp Arg Asn 
         115                120                125
Ala Asn Ser Tyr Val Met Val Gly Thr Phe Asn Leu Pro Ser Asp Gly 
     130                135                140
Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
 145                150                155                160
Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                 165                170                175
Gln Thr Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Asn Gln Ala Gln 
             180                185                190
Ala Ser Gln Pro Pro Pro Gln Thr Pro Thr Val Ala Ser Glu Thr Val 
         195                200                205
Ala Leu Asn Ser Gln Thr Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
     210                215                220
Arg Glu Pro Met Glu Ser Glu Glu Met Glu Glu Arg Pro Pro Thr Gln 
 225                230                235                240
Thr Pro Glu Leu Pro Pro Ser Gly Pro Ala Pro Ala Gly Pro Ala Pro 
                 245                250                255
Ala Pro Glu Thr Asn Ala Pro Thr Gln Pro Ser Pro Ala Glu His Val 
             260                265                270
Glu Val Leu Gln Glu Leu Gln Arg Leu Gln Arg Arg Leu Gln Pro Phe 
         275                280                285
Leu Gln Arg Tyr Cys Glu Val Leu Gly Ala Ala Ala Thr Thr Asp Tyr 
     290                295                300
Asn Asn Asn His Glu Gly Arg Glu Glu Asp Gln Arg Leu Ile Asn Leu 
 305                310                315                320
Val Gly Glu Ser Leu Arg Leu Leu Gly Asn Thr Phe Val Ala Leu Ser 
                 325                330                335
Asp Leu Arg Cys Asn Leu Ala Cys Ala Pro Pro Arg His Leu His Val 
             340                345                350
Val Arg Pro Met Ser His Tyr Thr Thr Pro Met Val Leu Gln Gln Ala 
         355                360                365
Ala Ile Pro Ile Gln Ile Asn Val Gly Thr Thr Val Thr Met Thr Gly 
     370                375                380
Asn Gly Ala Arg Pro Pro Pro Ala Pro Gly Ala Glu Ala Ala Ser Pro 
 385                390                395                400
Gly Ser Gly Gln Ala Ser Ser Leu Pro Pro Ser Ser Ala Thr Val Asp 
                 405                410                415
Ser Ser Thr Glu Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala 
             420                425                430
Thr Ser His Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro 
         435                440                445
Val Val Met Met His Met Asn Ile Gln Asp Ser Gly Ala Gln Pro Gly 
     450                455                460
Gly Val Pro Ser Ala Pro Thr Gly Pro Leu Gly Pro Pro Gly His Gly 
 465                470                475                480
Gln Ser Leu Gly Gln Gln Val Pro Gly Phe Pro Thr Ala Pro Thr Arg 
                 485                490                495
Val Val Ile Ala Arg Pro Thr Pro Pro Gln Ala Arg Pro Ser His Pro 
             500                505                510
Gly Gly Pro Pro Val Ser Gly Ala Leu Gly Ala Gly Leu Gly Thr Asn 
         515                520                525
Thr Ser Leu Ala Gln Met Val Ser Gly Leu Val Gly Gln Leu Leu Met 
     530                535                540
Gln Pro Val Leu Val Ala Gln Gly Thr Pro Gly Met Ala Pro Ala Ser 
 545                550                555                560
Ala Ser Ala Pro Ala Thr Ala Gln Ala Gln Ala Gln Ala Pro Ala Pro 
                 565                570                575
Ala Pro Ala Pro Ala Pro Ala Pro Ala Thr Ala Ser Ala Ser Ala Gly 
             580                585                590
Thr Thr Asn Thr Ala Thr Thr Ala Gly Pro Ala Pro Gly Gly Pro Ala 
         595                600                605
Gln Pro Pro Pro Pro Gln Pro Ser Ala Ala Asp Leu Gln Phe Ser Gln 
     610                615                620
Leu Leu Gly Asn Leu Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly Pro 
 625                630                635                640
Ser Leu Ala Ser Pro Thr Ile Thr Val Ala Val Pro Gly Val Pro Ala 
                 645                650                655
Phe Leu Gln Gly Met Thr Glu Phe Leu Gln Ala Ser Gln Ala Ala Pro 
             660                665                670
Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln Gln 
         675                680                685
Thr Thr Pro Pro Pro Gly Ser Pro Ser Gly Gly Thr Ala Ser Pro Gly 
     690                695                700
Gly Leu Gly Pro Glu Ser Leu Pro Pro Glu Phe Phe Thr Ser Val Val 
 705                710                715                720
Gln Gly Val Leu Ser Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala Gly 
                 725                730                735
Ser Ser Glu Ser Ile Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser Ser 
             740                745                750
Asn Ile Phe Glu Pro Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly Ala 
         755                760                765
Leu Leu Ser Leu Leu Cys Gln Asn Phe Ser Met Val Asp Val Val Met 
     770                775                780
Leu Leu His Gly His Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln Leu 
 785                790                795                800
Arg Ser Phe Phe His Gln His Tyr Leu Gly Gly Gln Glu Pro Thr Ser 
                 805                810                815
Ser Asn Ile Arg Met Ala Thr His Thr Leu Ile Thr Gly Leu Glu Glu 
             820                825                830
Tyr Val Arg Glu Ser Phe Ser Leu Val Gln Val Gln Pro Gly Val Asp 
         835                840                845
Ile Ile Arg Thr Asn Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser Ile 
     850                855                860
Ala Ala His Val Leu His Cys Thr Asp Ser Gly Phe Gly Ala Arg Leu 
 865                870                875                880
Leu Glu Leu Cys Asn Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn Leu 
                 885                890                895
His Cys Leu Gly Gly Gln Gln Met Glu Leu Ala Ala Val Ile Asn Gly 
             900                905                910
Arg Ile Arg Arg Met Ser Arg Gly Val Asn Pro Ser Leu Val Ser Trp 
         915                920                925
Leu Thr Thr Met Met Gly Leu Arg Leu Gln Val Val Leu Glu His Met 
     930                935                940
Pro Val Gly Pro Asp Ala Ile Leu Arg Tyr Val Arg Arg Ile Gly Asp 
 945                950                955                960
Pro Pro Gln Ala Leu Pro Glu Glu Pro Met Glu Val Gln Gly Ala Glu 
                 965                970                975
Arg Thr Ser Pro Glu Pro Gln Arg Glu Asp Ala Ser Pro Ala Pro Gly 
             980                985                990
Thr Thr Ala Glu Glu Ala Met Ser Arg Gly Pro Pro Pro Ala Pro Glu 
         995                1000                1005
Gly Gly Ser Arg Asp Glu Gln Asp Gly Ala Ser Ala Asp Ala Glu Pro 
     1010                1015                1020
Trp Ala Ala Ala Val Pro Pro Glu Trp Val Pro Ile Ile Gln Gln Asp 
 1025                1030                1035                1040
Ile Gln Ser Gln Arg Lys Val Lys Pro Gln Pro Pro Leu Ser Asp Ala 
                 1045                1050                1055
Tyr Leu Ser Gly Met Pro Ala Lys Arg Arg Lys Leu Arg Ser Asp Ile 
             1060                1065                1070
Gln Lys Arg Leu Gln Glu Asp Pro Asn Tyr Ser Pro Gln Arg Phe Pro 
         1075                1080                1085
Asn Ala His Arg Ala Phe Ala Asp Asp Pro 
     1090                1095



<210> 6537
<211> 3702
<212> DNA
<213> Homo sapiens
<308> BC003133
<400> 6537

ctcctcggg  tgctcggct  cctcccacc  aggccggcc  cggcccgac  cgccctcag  60
aactcactg  ttggggctg  ggactttct  gtcgtgccc  acaaaagta  agcttgggg  120
cctgggggg  gccggaagt  tcgcttcga  atccccaaa  actatcggg  aaacggaag  180
ggccgtcgg  ggcagagac  tgtcggcca  ggagcctaa  gatagtacc  gtaccgctg  240
ggaggagcc  gacagcttg  aggtgttgg  gaagacctt  gactctcaa  ctcgtacct  300
tattgtggg  gcccagatg  atgtaaaag  gtttaagga  cacattgct  cctctgtca  360
catcccatc  gaaaaacaa  ggctcattt  ccagggacg  gttctgcaa  atgataaga  420
gcttcagga  tacaatgtt  ggggaaagg  tatccacct  gtggaacgg  ctcctcctc  480
gactcacct  ccttctggg  catcttctg  gacggggtc  gcctcagcc  ctcatggtg  540
gggatcccc  cctggtact  gggggcctg  ggcctctgt  catgaccgg  atgccaaca  600
ctatgtcat  gttggaacc  tcaatcttc  tagtgacgg  tctgctgtg  atgttcaca  660
caacatgga  caggccccg  ttcagagtg  gccccgggt  cggctggtg  tggctcagc  720
catgatcag  gatatacag  ccttactat  ccggatgga  tgtcgagga  ggccccaac  780
gcagcacag  cagccgccc  cgcagccac  ggctgtgac  ccggagcca  tagccttga  840
ctctcaaac  tcagaacca  ttgaaagtg  agcacctcc  cgggagccc  tggaggcag  900
agaagtgga  gagcgtgcc  cagcccaga  cccggagct  actcctggc  cagccccag  960
gggcccaac  cctgccccg  aaacaaatg  acccaacca  ccttcccct  cggagtatg  1020
cgaggtgct  caggagcta  agcggctgg  gagtcgcct  cagcccttc  tgcagcgct  1080
ctacgaggt  ctgggtgct  ctgccacca  ggactacaa  aacaatcac  agggccggg  1140
ggaggatca  cggttgatc  acttggtag  ggagagcct  cgactgctg  gcaacacct  1200
tgttgcact  tctgacctg  gctgcaatc  ggcctgcac  cccccacga  acctgcatg  1260
ggtccggcc  atgtctcac  acaccaccc  catggtgct  cagcaggca  ccattccca  1320
acagatcaa  gtgggaacc  ctgtgacca  gacaggaaa  gggactcgg  cccccccaa  1380
tcccaatgc  gaggcacct  cccctggtc  tgggcaggc  tcatccgtg  ctccgtctt  1440
taccaatgt  gagtcctca  ctgaggggg  tcccccgcc  ggtccagct  ccccgccag  1500
caccagcca  ccgagggtc  tccggattt  ccaccagag  gtggaaccc  tggtcatga  1560
gcacatgaa  attcaagat  ctggcacac  gcctggtgg  gttccgagt  ctcccactg  1620
ccccctggg  ccccctggt  atggccaaa  cctgggaca  caggtgcca  gcttcccaa  1680
agctccaac  cgggtggtg  ttgcccggc  cactcctcc  caggctcgg  cttcccatc  1740
tggagggcc  ccagtctct  ggacactgc  gggcgccgg  ctgggtacc  atgcctcgt  1800
ggcccagat  gtgagcggc  ttgtggggc  gcttcttat  cagccagtc  ttgtggctc  1860
ggggacccc  ggtatggct  caccgccag  ccctgccac  gcttctgcc  gtgctggca  1920
caccaacac  gctaccaca  ctggccccg  tcctggggg  cctgcccag  ctccaccca  1980
ccctcaacc  tccatggct  atcttcagt  ctctcagct  ctggggaac  tgctagggc  2040
tgcagggcc  ggggctgga  ggtctggtg  ggcttctcc  accatcact  tggcgatgc  2100
tggtgtccc  gcctttctc  aaggcatga  tgacttctt  caggcaaca  agacagccc  2160
tccaccacc  ccacctcct  cacccccac  acctgcccc  gagcagcag  ccatgcccc  2220
accaggctc  ccttctggt  gcgcaggga  tcctggagg  ctgggtctt  agagcctgt  2280
accggagtt  tttacctca  tggtgcagg  tgtgctcag  tccctgctg  gctccctgg  2340
ggctcgggc  ggcagcagt  aaagtattg  tgccttcat  caacgcctc  gtggatcca  2400
caacatctt  gagcctgga  ctgatgggg  ccttggatt  tttggggcc  tgctttctc  2460
tctgtgcca  aacttctct  tggtggacg  agtgatgct  ctccatggg  atttccagc  2520
actacaacg  ctccagccc  agctgcgat  cttcttcca  cagcactac  tgggtggtc  2580
ggagcccac  cccagtaac  tccggatgg  aacccacac  ttgatcacg  ggctagaag  2640
gtatgtgcg  gagagtttt  ccttggtgc  ggttcagcc  ggtgtggac  tcatccgga  2700
aaacctgga  tttctccaa  agcagttta  tagcattgc  gcgcatgtg  tgcattgca  2760
agatagtgg  tttggggcc  ggttgctgg  gttgtgtaa  caaggcctg  ttgaatgcc  2820
ggccctaaa  ctgcactgc  tggggggac  gcagatgga  cttgctgct  ttatcaatg  2880
ccgaattcg  cgtatgtct  gtggggtga  tccctcctt  gtgagctgg  tgaccacta  2940
gatgggact  aggcttcag  tggtactgg  gcacatgcc  gtaggccct  atgccattc  3000
cagatacgt  cgcagggtt  gtgatcccc  ccagccact  cctgaggag  caatggaag  3060
tcagggagc  gaaagagct  cccctgagc  tcagcggga  aatgcttcc  cagcccctg  3120
aacaacagc  gaagaggcc  tgtcccgag  tccacctcc  gctcctgag  ggggctccc  3180
ggatgaaca  gatggagct  cagctgaga  agaaccttg  gcagctgca  tccccccag  3240
atgggtccc  attatccag  aggacattc  gagccagcg  aaggtgaaa  cgcagcccc  3300
tctgagtga  gcctacctc  gtggtatgc  tgccaagag  cgcaagacg  tgcagggtg  3360
gggccccca  ctgcttctc  cagaggctg  gagccgggc  gctaaggca  ccggagctc  3420
gcccctgac  agccccgag  gcctgagcc  ggacctgga  gcaccagag  ttcaggaga  3480
ctacaggca  cagctccgg  ctgatatac  aaaacgact  caggaagac  ccaactaca  3540
tccccagcg  ttccccaat  cccagcggg  ctttgctga  gatccttag  tctttgctc  3600
atggccctt  ctcatcagg  gaccgtttc  cccctcttc  ttcacagta  ttaagaaat  3660
aaagtcgga  ttttctggc  aaaaaaaaa  aaaaaaaaa  aa  3702



<210> 6538
<211> 1132
<212> PRT
<213> Homo sapiens
<308> P46379
<400> 6538

Met Glu Pro Asn Asp Ser Thr Ser Thr Ala Val Glu Glu Pro Asp Ser 
  1               5                  10                  15
Leu Glu Val Leu Val Lys Thr Leu Asp Ser Gln Thr Arg Thr Phe Ile 
             20                  25                  30
Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Arg Ala 
         35                  40                  45
Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
     50                  55                  60
Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
 65                  70                  75                  80
Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Thr His Leu Pro Ser 
                 85                  90                  95
Gly Ala Ser Ser Gly Thr Gly Ser Ala Ser Ala Thr His Gly Gly Gly 
             100                105                110
Ser Pro Pro Gly Thr Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
         115                120                125
Ala Asn Ser Tyr Val Met Val Gly Thr Phe Asn Leu Pro Ser Asp Gly 
     130                135                140
Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
 145                150                155                160
Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                 165                170                175
Gln Thr Leu Leu Ser Arg Met Glu Thr Leu Pro Tyr Leu Gln Cys Arg 
             180                185                190
Gly Gly Pro Gln Pro Gln His Ser Gln Pro Pro Pro Gln Pro Pro Ala 
         195                200                205
Val Thr Pro Glu Pro Val Ala Leu Ser Ser Gln Thr Ser Glu Pro Val 
     210                215                220
Glu Ser Glu Ala Pro Pro Arg Glu Pro Met Glu Ala Glu Glu Val Glu 
 225                230                235                240
Glu Arg Ala Pro Ala Gln Asn Pro Glu Leu Thr Pro Gly Pro Ala Pro 
                 245                250                255
Ala Gly Pro Thr Pro Ala Pro Glu Thr Asn Ala Pro Asn His Pro Ser 
             260                265                270
Pro Ala Glu Tyr Val Glu Val Leu Gln Glu Leu Gln Arg Leu Glu Ser 
         275                280                285
Arg Leu Gln Pro Phe Leu Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala 
     290                295                300
Ala Thr Thr Asp Tyr Asn Asn Asn His Glu Gly Arg Glu Glu Asp Gln 
 305                310                315                320
Arg Leu Ile Asn Leu Val Gly Glu Ser Leu Arg Leu Leu Gly Asn Thr 
                 325                330                335
Phe Val Ala Leu Ser Asp Leu Arg Cys Asn Leu Ala Cys Thr Pro Pro 
             340                345                350
Arg His Leu His Val Val Arg Pro Met Ser His Tyr Thr Thr Pro Met 
         355                360                365
Val Leu Gln Gln Ala Ala Ile Pro Ile Gln Ile Asn Val Gly Thr Thr 
     370                375                380
Val Thr Met Thr Gly Asn Gly Thr Arg Pro Pro Pro Thr Pro Asn Ala 
 385                390                395                400
Glu Ala Pro Pro Pro Gly Pro Gly Gln Ala Ser Ser Val Ala Pro Ser 
                 405                410                415
Ser Thr Asn Val Glu Ser Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro 
             420                425                430
Ala Pro Pro Pro Ala Thr Ser His Pro Arg Val Ile Arg Ile Ser His 
         435                440                445
Gln Ser Val Glu Pro Val Val Met Met His Met Asn Ile Gln Asp Ser 
     450                455                460
Gly Thr Gln Pro Gly Gly Val Pro Ser Ala Pro Thr Gly Pro Leu Gly 
 465                470                475                480
Pro Pro Gly His Gly Gln Thr Leu Gly Gln Gln Val Pro Gly Phe Pro 
                 485                490                495
Thr Ala Pro Thr Arg Val Val Ile Ala Arg Pro Thr Pro Pro Gln Ala 
             500                505                510
Arg Pro Ser His Pro Gly Gly Pro Pro Val Ser Gly Thr Leu Gln Gly 
         515                520                525
Ala Gly Leu Gly Thr Asn Ala Ser Leu Ala Gln Met Val Ser Gly Leu 
     530                535                540
Val Gly Gln Leu Leu Met Gln Pro Val Leu Val Ala Gln Gly Thr Pro 
 545                550                555                560
Gly Met Ala Pro Pro Pro Ala Pro Ala Thr Ala Ser Ala Ser Ala Gly 
                 565                570                575
Thr Thr Asn Thr Ala Thr Thr Ala Gly Pro Ala Pro Gly Gly Pro Ala 
             580                585                590
Gln Pro Pro Pro Thr Pro Gln Pro Ser Met Ala Asp Leu Gln Phe Ser 
         595                600                605
Gln Leu Leu Gly Asn Leu Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly 
     610                615                620
Pro Gly Val Ala Ser Pro Thr Ile Thr Val Ala Met Pro Gly Val Pro 
 625                630                635                640
Ala Phe Leu Gln Gly Met Thr Asp Phe Leu Gln Ala Thr Gln Thr Ala 
                 645                650                655
Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln 
             660                665                670
Gln Thr Met Pro Pro Pro Gly Ser Pro Ser Gly Gly Ala Gly Ser Pro 
         675                680                685
Gly Gly Leu Gly Leu Glu Ser Leu Ser Pro Glu Phe Phe Thr Ser Val 
     690                695                700
Val Gln Gly Val Leu Ser Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala 
 705                710                715                720
Gly Ser Ser Glu Ser Ile Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser 
                 725                730                735
Ser Asn Ile Phe Glu Pro Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly 
             740                745                750
Ala Leu Leu Ser Leu Leu Cys Gln Asn Phe Ser Met Val Asp Val Val 
         755                760                765
Met Leu Leu His Gly His Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln 
     770                775                780
Leu Arg Ser Phe Phe His Gln His Tyr Leu Gly Gly Gln Glu Pro Thr 
 785                790                795                800
Pro Ser Asn Ile Arg Met Ala Thr His Thr Leu Ile Thr Gly Leu Glu 
                 805                810                815
Glu Tyr Val Arg Glu Ser Phe Ser Leu Val Gln Val Gln Pro Gly Val 
             820                825                830
Asp Ile Ile Arg Thr Asn Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser 
         835                840                845
Ile Ala Ala His Val Leu His Cys Thr Asp Ser Gly Phe Gly Ala Arg 
     850                855                860
Leu Leu Glu Leu Cys Asn Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn 
 865                870                875                880
Leu His Cys Leu Gly Gly Gln Gln Met Glu Leu Ala Ala Val Ile Asn 
                 885                890                895
Gly Arg Ile Arg Arg Met Ser Arg Gly Val Asn Pro Ser Leu Val Ser 
             900                905                910
Trp Leu Thr Thr Met Met Gly Leu Arg Leu Gln Val Val Leu Glu His 
         915                920                925
Met Pro Val Gly Pro Asp Ala Ile Leu Arg Tyr Val Arg Arg Val Gly 
     930                935                940
Asp Pro Pro Gln Pro Leu Pro Glu Glu Pro Met Glu Val Gln Gly Ala 
 945                950                955                960
Glu Arg Ala Ser Pro Glu Pro Gln Arg Glu Asn Ala Ser Pro Ala Pro 
                 965                970                975
Gly Thr Thr Ala Glu Glu Ala Met Ser Arg Gly Pro Pro Pro Ala Pro 
             980                985                990
Glu Gly Gly Ser Arg Asp Glu Gln Asp Gly Ala Ser Ala Glu Thr Glu 
         995                1000                1005
Pro Trp Ala Ala Ala Val Pro Pro Glu Trp Val Pro Ile Ile Gln Gln 
     1010                1015                1020
Asp Ile Gln Ser Gln Arg Lys Val Lys Pro Gln Pro Pro Leu Ser Asp 
 1025                1030                1035                1040
Ala Tyr Leu Ser Gly Met Pro Ala Lys Arg Arg Lys Thr Met Gln Gly 
                 1045                1050                1055
Glu Gly Pro Gln Leu Leu Leu Ser Glu Ala Val Ser Arg Ala Ala Lys 
             1060                1065                1070
Ala Ala Gly Ala Arg Pro Leu Thr Ser Pro Glu Ser Leu Ser Arg Asp 
         1075                1080                1085
Leu Glu Ala Pro Glu Val Gln Glu Ser Tyr Arg Gln Gln Leu Arg Ser 
     1090                1095                1100
Asp Ile Gln Lys Arg Leu Gln Glu Asp Pro Asn Tyr Ser Pro Gln Arg 
 1105                1110                1115                1120
Phe Pro Asn Ala Gln Arg Ala Phe Ala Asp Asp Pro 
                 1125                1130



<210> 6539
<211> 612
<212> DNA
<213> Rattus norvegicus
<308> AI010453
<400> 6539

gcagaagca  caggccagg  cagcctgag  ttaatatta  taggaaggg  acccgatcc  60
gaagggatg  gacttctga  gacagtgat  aacgtgtgg  atctatcac  tttcccaca  120
agagggggc  ctgagtttc  gattcaact  tcatgaaaa  gaaagggtg  tcgaacttc  180
cttgagggg  cagagacat  gggacggcc  ccaccacag  ggctcctgc  gcctctgtt  240
ccctctcat  taaggtcag  acagcctta  gcacagcct  gctaagctt  aggggggca  300
cctctgtga  tccagagag  tcagcatca  tgttgaaga  ccgggtgat  cccagtgag  360
tcaggagtg  cttcaagtt  taggttcca  agatggaca  tttggggaa  tagagaatg  420
ctgaccttg  ttgcctgtt  agcaggaac  gggaaatga  atccttggn  agagtttgc  480
ccagatgct  catcttgcc  tcatcgggc  ggaggaaga  ggcagtggc  ttgcccagg  540
aatccatca  cagcaccca  ctggacagt  tgctgcaat  gggcatgtc  aacatgccc  600
ggcggttca  ca  612



<210> 6540
<211> 411
<212> PRT
<213> Rattus norvegicus
<308> P17475
<400> 6540

Met Ala Pro Ser Ile Ser Arg Gly Leu Leu Leu Leu Ala Ala Leu Cys 
  1               5                  10                  15
Cys Leu Ala Pro Ser Phe Leu Ala Glu Asp Ala Gln Glu Thr Asp Thr 
             20                  25                  30
Ser Gln Gln Asp Gln Ser Pro Thr Tyr Arg Lys Ile Ser Ser Asn Leu 
         35                  40                  45
Ala Asp Phe Ala Phe Ser Leu Tyr Arg Glu Leu Val His Gln Ser Asn 
     50                  55                  60
Thr Ser Asn Ile Phe Phe Ser Pro Met Ser Ile Thr Thr Ala Phe Ala 
 65                  70                  75                  80
Met Leu Ser Leu Gly Ser Lys Gly Asp Thr Arg Lys Gln Ile Leu Glu 
                 85                  90                  95
Gly Leu Glu Phe Asn Leu Thr Gln Ile Pro Glu Ala Asp Ile His Lys 
             100                105                110
Ala Phe His His Leu Leu Gln Thr Leu Asn Arg Pro Asp Ser Glu Leu 
         115                120                125
Gln Leu Asn Thr Gly Asn Gly Leu Phe Val Asn Lys Asn Leu Lys Leu 
     130                135                140
Val Glu Lys Phe Leu Glu Glu Val Lys Asn Asn Tyr His Ser Glu Ala 
 145                150                155                160
Phe Ser Val Asn Phe Ala Asp Ser Glu Glu Ala Lys Lys Val Ile Asn 
                 165                170                175
Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Met Lys 
             180                185                190
Gln Leu Asp Glu Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe 
         195                200                205
Lys Gly Lys Trp Lys Arg Pro Phe Asn Pro Glu His Thr Arg Asp Ala 
     210                215                220
Asp Phe His Val Asp Lys Ser Thr Thr Val Lys Val Pro Met Met Asn 
 225                230                235                240
Arg Leu Gly Met Phe Asp Met His Tyr Cys Ser Thr Leu Ser Ser Trp 
                 245                250                255
Val Leu Met Met Asp Tyr Leu Gly Asn Ala Thr Ala Ile Phe Leu Leu 
             260                265                270
Pro Asp Asp Gly Lys Met Gln His Leu Glu Gln Thr Leu Thr Lys Asp 
         275                280                285
Leu Ile Ser Arg Phe Leu Leu Asn Arg Gln Thr Arg Ser Ala Ile Leu 
     290                295                300
Tyr Phe Pro Lys Leu Ser Ile Ser Gly Thr Tyr Asn Leu Lys Thr Leu 
 305                310                315                320
Leu Ser Ser Leu Gly Ile Thr Arg Val Phe Asn Asn Asp Ala Asp Leu 
                 325                330                335
Ser Gly Ile Thr Glu Asp Ala Pro Leu Lys Leu Ser Gln Ala Val His 
             340                345                350
Lys Ala Val Leu Thr Leu Asp Glu Arg Gly Thr Glu Ala Ala Gly Ala 
         355                360                365
Thr Val Val Glu Ala Val Pro Met Ser Leu Pro Pro Gln Val Lys Phe 
     370                375                380
Asp His Pro Phe Ile Phe Met Ile Val Glu Ser Glu Thr Gln Ser Pro 
 385                390                395                400
Leu Phe Val Gly Lys Val Ile Asp Pro Thr Arg 
                 405                410



<210> 6541
<211> 1337
<212> DNA
<213> Homo sapiens
<308> XM_028358
<400> 6541

gacaatgcc  tcttctgtc  cgtggggca  cctcctgct  gcaggcctg  gctgcctgg  60
ccctgtctc  ctggctgag  atccccagg  agatgctgc  cagaagaca  atacatccc  120
ccatgatca  gatcaccca  ccttcaaca  gatcacccc  aacctggct  agttcgcct  180
cagcctata  cgccagctg  cacaccagt  caacagcac  aatatcttc  tctccccag  240
gagcatcgc  acagccttt  caatgctct  cctggggac  aaggctgac  ctcacgatg  300
aatcctgga  ggcctgaat  tcaacctca  ggagattcc  gaggctcag  tccatgaag  360
cttccagga  ctcctccgt  ccctcaacc  gccagacag  cagctccag  tgaccaccg  420
caatggcct  ttcctcagc  agggcctga  gctagtgga  aagtttttg  aggatgtta  480
aaagttgta  cactcagaa  ccttcactg  caacttcgg  gacaccgaa  aggccaaga  540
acagatcaa  gattacgtg  agaagggta  tcaagggaa  attgtggat  tggtcaagg  600
gcttgacag  gacacagtt  ttgctctgg  gaattacat  ttctttaaa  gcaaatggg  660
gagaccctt  gaagtcaag  acaccgagg  agaggactt  cacgtggac  aggcgacca  720
cgtgaaggt  cctatgatg  agcgtttag  catgtttaa  atccagcac  gtaagaagc  780
gtccagctg  gtgctgctg  tgaaatacc  gggcaatgc  accgccatc  tcttcctgc  840
tgatgaggg  aaactacag  acctggaaa  tgaactcac  cacgatatc  tcaccaagt  900
cctggaaaa  gaagacaga  ggtctgcca  cttacattt  cccaaactg  ccattactg  960
aacctatga  ctgaagagc  tcctgggtc  actgggcat  actaaggtc  tcagcaatg  1020
ggctgacct  tccggggtc  cagaggagg  acccctgaa  ctctccaag  ccgtgcata  1080
ggctgtgct  accatcgac  agaaaggga  tgaagctgc  ggggccatg  ttttagagg  1140
catacccat  tctatcccc  ccgaggtca  gttcaacaa  ccctttgtc  tcttaatga  1200
tgaacaaaa  accaagtct  ccctcttca  gggaaaagt  gtgaatccc  cccaaaaat  1260
actgcctct  gctcctcaa  ccctcccct  catccctgg  cccctccct  gatgacatt  1320
aagaagggt  gagctgg  1337



<210> 6542
<211> 418
<212> PRT
<213> Homo sapiens
<308> XP_028358
<400> 6542

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
  1               5                  10                  15
Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
             20                  25                  30
Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
         35                  40                  45
Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
     50                  55                  60
Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
 65                  70                  75                  80
Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                 85                  90                  95
His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
             100                105                110
Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
         115                120                125
Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
     130                135                140
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
 145                150                155                160
Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                 165                170                175
Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
             180                185                190
Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
         195                200                205
Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
     210                215                220
Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Ala Thr Thr Val 
 225                230                235                240
Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                 245                250                255
Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
             260                265                270
Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
         275                280                285
Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
     290                295                300
Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
 305                310                315                320
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                 325                330                335
Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
             340                345                350
Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
         355                360                365
Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
     370                375                380
Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
 385                390                395                400
Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                 405                410                415
Gln Lys 
             420



<210> 6543
<211> 590
<212> DNA
<213> Rattus norvegicus
<308> AI010480
<400> 6543

gaaaaagaa  atcagactg  tttattgtc  ttatcaaca  cccatagtt  ggaagggat  60
ctgatgctg  cacaacacc  tccaacaag  aaattagac  ctcaagtag  tcaatgaca  120
gatgctgaa  aagttagga  gctgctgct  ctgctgctg  tggaggctc  aggctcaca  180
tcacttcat  ttcttcaca  agtcctcgc  tttcttgat  gaggctttc  gctcaggga  240
ggcctcggc  atcattttc  cctcaaaag  agtgatttt  ccaatgcct  ggttcttct  300
caggccttt  ttccccaac  gcaagggtg  agagaaata  gtgcactct  tctctttgg  360
ctgaacaaa  gagcactcg  tgactcctt  cttcccatt  atggcgtcc  ccagggaga  420
gacaaagcg  gctccagca  aagccatgg  cagagtggc  gagcctgct  cagccttgg  480
cttcacgac  tcagtgcca  cctcctgga  cctcccggt  agtgtggcc  gctggtctt  540
gggaaagtc  accttgggg  tacactgag  gatcagggg  atgatcgtct  590



<210> 6544
<211> 338
<212> PRT
<213> Rattus norvegicus
<308> P04636
<400> 6544

Met Leu Ser Ala Leu Ala Arg Pro Val Gly Ala Ala Leu Arg Arg Ser 
  1               5                  10                  15
Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala 
             20                  25                  30
Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro 
         35                  40                  45
Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val 
     50                  55                  60
Ala Ala Asp Leu Ser His Ile Glu Thr Arg Ala Asn Val Lys Gly Tyr 
 65                  70                  75                  80
Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val 
                 85                  90                  95
Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp 
             100                105                110
Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys 
         115                120                125
Ala Gln His Cys Pro Glu Ala Met Ile Cys Ile Ile Ser Asn Pro Val 
     130                135                140
Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val 
 145                150                155                160
Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg 
                 165                170                175
Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val 
             180                185                190
Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu 
         195                200                205
Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Ala 
     210                215                220
Thr Leu Thr Gly Lys Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala 
 225                230                235                240
Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala 
                 245                250                255
Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val 
             260                265                270
Ile Glu Cys Ser Phe Val Gln Ser Lys Glu Thr Glu Cys Thr Tyr Phe 
         275                280                285
Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Leu Glu Lys Asn Leu Gly 
     290                295                300
Ile Gly Lys Ile Thr Pro Phe Glu Glu Lys Met Ile Ala Glu Ala Ile 
 305                310                315                320
Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Asn 
                 325                330                335
Met Lys 
             340



<210> 6545
<211> 1321
<212> DNA
<213> Homo sapiens
<308> NM_005918
<400> 6545

ggcgctggg  agtgtggag  tcgttggag  cacttccgc  tcaccagct  ctgtgcctg  60
cagtcggtg  ccctcccgc  ccagccatg  tctccgccc  cgcccggcc  gccagcgct  120
ctctccgcc  cagcttcag  acctcggcc  agaacaatg  taaagtagc  gtgctaggg  180
cctctggag  catcgggca  ccactttca  ttctcctga  gaacagccc  ttggtgagc  240
gcctgaccc  ctatgatat  gcgcacaca  ccggagtgg  cgcagatct  agccacatc  300
agaccaaag  cgctgtgaa  ggctacctc  gacctgaac  gctgcctga  tgcctgaaa  360
gttgtgatg  ggtagttat  ccggctgga  tccccagaa  gccaggcat  acccgggac  420
acctgttca  caccaatgc  acgattgtg  ccaccctga  cgctgcctg  gcccagcac  480
gcccggaag  catgatctg  gtcattgcc  atccggtta  ttccaccat  cccatcaca  540
cagaagttt  caagaagca  ggagtgtac  accccaaca  aatcttcgg  gtgacgacc  600
tggacatcg  cagagccaa  acctttgtt  cagagctga  gggtttgga  ccagctcga  660
tcaacgtcc  tgtcattgg  ggccatgct  ggaagacca  catccccct  atctctcag  720
gcaccccca  ggtggactt  ccccaggac  agctgacag  actcactgg  cggatccag  780
aggccggca  ggaggtggt  aaggctaaa  ccggagcag  ctctgccac  ctctccatg  840
cgtatgccg  cgcccgctt  gtcttctcc  ttgtggatg  aatgaatgg  aaggaaggt  900
ttgtggaat  ttccttcgt  aagtcacag  aaacggaat  tacctactt  tccacaccg  960
tgctgcttg  gaaaaaggg  atcgagaag  acctgggca  cggcaaagt  tcctctttt  1020
aggagaaga  gatctcgga  gccatcccc  agctgaagg  ctccatcaa  aagggggaa  1080
atttcgtga  gaccctgaa  tgagccgct  tgacgggtg  ccagtttcc  taatttatg  1140
aggcatcat  tcactgcaa  gccgttgca  ataaacttt  tattttaat  tgctttggt  1200
atgattact  tattgacat  atcatgcct  ccaaattgt  ggtggctct  tgggcgcat  1260
aataaaagc  gtccttgat  ttatttttc  aggtccctt  tgtaaaaaa  aaaaaaaaa  1320
a  1321



<210> 6546
<211> 338
<212> PRT
<213> Homo sapiens
<308> P40926
<400> 6546

Met Leu Ser Ala Leu Ala Arg Pro Val Ser Ala Ala Leu Arg Arg Ser 
  1               5                  10                  15
Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala 
             20                  25                  30
Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro 
         35                  40                  45
Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val 
     50                  55                  60
Ala Ala Asp Leu Ser His Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr 
 65                  70                  75                  80
Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val 
                 85                  90                  95
Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp 
             100                105                110
Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys 
         115                120                125
Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile Ala Asn Pro Val 
     130                135                140
Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val 
 145                150                155                160
Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg 
                 165                170                175
Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val 
             180                185                190
Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu 
         195                200                205
Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Thr 
     210                215                220
Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala 
 225                230                235                240
Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala 
                 245                250                255
Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val 
             260                265                270
Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe 
         275                280                285
Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly 
     290                295                300
Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile Ser Asp Ala Ile 
 305                310                315                320
Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Thr 
                 325                330                335
Leu Lys 
             340



<210> 6547
<211> 590
<212> DNA
<213> Rattus norvegicus
<308> AI010480
<400> 6547

gaaaaagaa  atcagactg  tttattgtc  ttatcaaca  cccatagtt  ggaagggat  60
ctgatgctg  cacaacacc  tccaacaag  aaattagac  ctcaagtag  tcaatgaca  120
gatgctgaa  aagttagga  gctgctgct  ctgctgctg  tggaggctc  aggctcaca  180
tcacttcat  ttcttcaca  agtcctcgc  tttcttgat  gaggctttc  gctcaggga  240
ggcctcggc  atcattttc  cctcaaaag  agtgatttt  ccaatgcct  ggttcttct  300
caggccttt  ttccccaac  gcaagggtg  agagaaata  gtgcactct  tctctttgg  360
ctgaacaaa  gagcactcg  tgactcctt  cttcccatt  atggcgtcc  ccagggaga  420
gacaaagcg  gctccagca  aagccatgg  cagagtggc  gagcctgct  cagccttgg  480
cttcacgac  tcagtgcca  cctcctgga  cctcccggt  agtgtggcc  gctggtctt  540
gggaaagtc  accttgggg  tacactgag  gatcagggg  atgatcgtct  590



<210> 6548
<211> 338
<212> PRT
<213> Rattus norvegicus
<308> P04636
<400> 6548

Met Leu Ser Ala Leu Ala Arg Pro Val Gly Ala Ala Leu Arg Arg Ser 
  1               5                  10                  15
Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala 
             20                  25                  30
Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro 
         35                  40                  45
Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val 
     50                  55                  60
Ala Ala Asp Leu Ser His Ile Glu Thr Arg Ala Asn Val Lys Gly Tyr 
 65                  70                  75                  80
Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val 
                 85                  90                  95
Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp 
             100                105                110
Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys 
         115                120                125
Ala Gln His Cys Pro Glu Ala Met Ile Cys Ile Ile Ser Asn Pro Val 
     130                135                140
Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val 
 145                150                155                160
Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg 
                 165                170                175
Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val 
             180                185                190
Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu 
         195                200                205
Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Ala 
     210                215                220
Thr Leu Thr Gly Lys Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala 
 225                230                235                240
Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala 
                 245                250                255
Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val 
             260                265                270
Ile Glu Cys Ser Phe Val Gln Ser Lys Glu Thr Glu Cys Thr Tyr Phe 
         275                280                285
Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Leu Glu Lys Asn Leu Gly 
     290                295                300
Ile Gly Lys Ile Thr Pro Phe Glu Glu Lys Met Ile Ala Glu Ala Ile 
 305                310                315                320
Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Asn 
                 325                330                335
Met Lys 
             340



<210> 6549
<211> 1321
<212> DNA
<213> Homo sapiens
<308> NM_005918
<400> 6549

ggcgctggg  agtgtggag  tcgttggag  cacttccgc  tcaccagct  ctgtgcctg  60
cagtcggtg  ccctcccgc  ccagccatg  tctccgccc  cgcccggcc  gccagcgct  120
ctctccgcc  cagcttcag  acctcggcc  agaacaatg  taaagtagc  gtgctaggg  180
cctctggag  catcgggca  ccactttca  ttctcctga  gaacagccc  ttggtgagc  240
gcctgaccc  ctatgatat  gcgcacaca  ccggagtgg  cgcagatct  agccacatc  300
agaccaaag  cgctgtgaa  ggctacctc  gacctgaac  gctgcctga  tgcctgaaa  360
gttgtgatg  ggtagttat  ccggctgga  tccccagaa  gccaggcat  acccgggac  420
acctgttca  caccaatgc  acgattgtg  ccaccctga  cgctgcctg  gcccagcac  480
gcccggaag  catgatctg  gtcattgcc  atccggtta  ttccaccat  cccatcaca  540
cagaagttt  caagaagca  ggagtgtac  accccaaca  aatcttcgg  gtgacgacc  600
tggacatcg  cagagccaa  acctttgtt  cagagctga  gggtttgga  ccagctcga  660
tcaacgtcc  tgtcattgg  ggccatgct  ggaagacca  catccccct  atctctcag  720
gcaccccca  ggtggactt  ccccaggac  agctgacag  actcactgg  cggatccag  780
aggccggca  ggaggtggt  aaggctaaa  ccggagcag  ctctgccac  ctctccatg  840
cgtatgccg  cgcccgctt  gtcttctcc  ttgtggatg  aatgaatgg  aaggaaggt  900
ttgtggaat  ttccttcgt  aagtcacag  aaacggaat  tacctactt  tccacaccg  960
tgctgcttg  gaaaaaggg  atcgagaag  acctgggca  cggcaaagt  tcctctttt  1020
aggagaaga  gatctcgga  gccatcccc  agctgaagg  ctccatcaa  aagggggaa  1080
atttcgtga  gaccctgaa  tgagccgct  tgacgggtg  ccagtttcc  taatttatg  1140
aggcatcat  tcactgcaa  gccgttgca  ataaacttt  tattttaat  tgctttggt  1200
atgattact  tattgacat  atcatgcct  ccaaattgt  ggtggctct  tgggcgcat  1260
aataaaagc  gtccttgat  ttatttttc  aggtccctt  tgtaaaaaa  aaaaaaaaa  1320
a  1321



<210> 6550
<211> 338
<212> PRT
<213> Homo sapiens
<308> P40926
<400> 6550

Met Leu Ser Ala Leu Ala Arg Pro Val Ser Ala Ala Leu Arg Arg Ser 
  1               5                  10                  15
Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala 
             20                  25                  30
Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro 
         35                  40                  45
Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val 
     50                  55                  60
Ala Ala Asp Leu Ser His Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr 
 65                  70                  75                  80
Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val 
                 85                  90                  95
Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp 
             100                105                110
Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys 
         115                120                125
Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile Ala Asn Pro Val 
     130                135                140
Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val 
 145                150                155                160
Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg 
                 165                170                175
Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val 
             180                185                190
Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu 
         195                200                205
Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Thr 
     210                215                220
Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala 
 225                230                235                240
Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala 
                 245                250                255
Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val 
             260                265                270
Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe 
         275                280                285
Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly 
     290                295                300
Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile Ser Asp Ala Ile 
 305                310                315                320
Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Thr 
                 325                330                335
Leu Lys 
             340



<210> 6551
<211> 377
<212> DNA
<213> Rattus norvegicus
<308> AI010580
<400> 6551

ccaaaacac  ccacaggtt  accagacag  ttccccccc  cccccacac  cacacattc  60
aatagacag  tccttcatg  gccagaagt  tgagactct  tccatgttg  ggagggcac  120
tcattcatt  accgacttc  gaaacctgc  tgtctttca  gggcaatgc  aagattgta  180
agttgcaat  ccagcatgg  agactgaca  ttcccagaa  tcctgtgtc  aggctcttc  240
agacctgaa  tggctcatg  gagctcggt  ggcagccag  gacctgtga  aagggagac  300
gaccctttt  tatttggag  cttccggag  tctcactct  agctttact  acattctgg  360
aaagctgag  aacccta  377



<210> 6552
<211> 497
<212> DNA
<213> Rattus norvegicus
<308> AI010581
<400> 6552

agagtaaca  atgtacttt  aattgattt  aggtaaaaa  tccaaagga  ggaggagca  60
taattaact  tggccctaa  atatcagag  catgtcatc  acattagaa  aaaaaaaaa  120
caccaaggc  ttatgtcct  acaggtatt  tgtcacaca  gtggctggc  accaaatct  180
gtcgtttat  ttccatatt  cttctttag  tcttctacc  tttccacat  ggtcttcat  240
gcattttcc  tggaagttc  tttcagctt  ttccacgag  cccacttgg  tttgccctt  300
aggtccaac  gccccggcc  atctgtgtt  acatcgccc  cagtagctt  tttgaagtg  360
ctgtagatg  acagcatct  ttcatcagt  ggctgagtc  tgaggcgct  cacctcctc  420
gcggctttg  caaaatcag  ctgagacat  ctggcgagg  gacctggat  ctgaaagcg  480
gggagcaag  tcagaag  497



<210> 6553
<211> 86
<212> PRT
<213> Rattus norvegicus
<308> P11030
<400> 6553

Ser Gln Ala Asp Phe Asp Lys Ala Ala Glu Glu Val Lys Arg Leu Lys 
  1               5                  10                  15
Thr Gln Pro Thr Asp Glu Glu Met Leu Phe Ile Tyr Ser His Phe Lys 
             20                  25                  30
Gln Ala Thr Val Gly Asp Val Asn Thr Asp Arg Pro Gly Leu Leu Asp 
         35                  40                  45
Leu Lys Gly Lys Ala Lys Trp Asp Ser Trp Asn Lys Leu Lys Gly Thr 
     50                  55                  60
Ser Lys Glu Asn Ala Met Lys Thr Tyr Val Glu Lys Val Glu Glu Leu 
 65                  70                  75                  80
Lys Lys Lys Tyr Gly Ile 
                 85



<210> 6554
<211> 1156
<212> DNA
<213> Homo sapiens
<308> BC000920
<400> 6554

caggccgca  ccctctgtt  caggaaacc  ttgggctta  gcctcactt  ctggtcctc  60
acaagatgg  cttggcgga  cttacagag  agcagaaaa  tatgcaaca  ttagaagga  120
aaggcctaa  aaatgtcat  tttaccaac  gtgtaaagg  tgaaaatgt  aagcagatc  180
tcccgatgg  cactgaact  attgggaga  gccaccgct  ccaccgaaa  gagaacctg  240
agtactgta  catggtcat  ggggtcccc  acgtgggca  gtcctccct  atcaactcc  300
tccggaggc  gcacctcag  aaagggaaa  ccaccaggg  gggtggcga  cctgggatc  360
ccagagctg  gatgtccaa  attcaggtc  ctgagcggc  cctgatgtt  ctgttggac  420
ctcctggcg  gctggctcc  cggattgaa  gtgtggaga  aggcctgaa  ctggccctg  480
gtggaacgg  gctggacca  ctggtcggg  aggagacca  ggctgacta  ctgctgtac  540
ccctcaaca  acaccagcg  tttgggtac  tgcagcact  cggcctggg  agtgcctgt  600
acaacgtag  gcgcgtgct  aagagtgtg  ctgtgaagc  ggggaagac  cagaaggtg  660
aggtgctca  gggcacggg  aacgtgaac  ttattcagc  taactatcc  gcggcagcc  720
gtgacttcc  gcagacttt  cgccgtggg  tgctgggtt  cgtgatgct  gacctcgac  780
tcctgcggg  ccacccccc  gctgagact  tgccctgaa  ttgtccggg  agggagggc  840
ggaggcatg  ggcctccca  acctcctga  ctgggtggt  gaggctcaa  acagctcac  900
cggtccaga  gctccatgc  ggtcactag  gtgctgtgc  ctctggcgc  ccacagcct  960
gccagctcc  gggacccca  ttgcagggg  caagcaggt  ggagtggac  ccaggcttc  1020
cagtggacg  ccctgagca  ctccgcatg  ttggttctc  cggagcttc  tgctcaggc  1080
tcttgagaa  tggatgctg  ctcagaagg  gttaaagct  taacctgta  cctttaaaa  1140
aaaaaaaaa  aaaaaa  1156



<210> 6555
<211> 86
<212> PRT
<213> Homo sapiens
<308> NZHU
<400> 6555

Ser Gln Ala Glu Phe Glu Lys Ala Ala Glu Glu Val Arg His Leu Lys 
  1               5                  10                  15
Thr Lys Pro Ser Asp Glu Glu Met Leu Phe Ile Tyr Gly His Tyr Lys 
             20                  25                  30
Gln Ala Thr Val Gly Asp Ile Asn Thr Glu Arg Pro Gly Met Leu Asp 
         35                  40                  45
Phe Thr Gly Lys Ala Lys Trp Asp Ala Trp Asn Glu Leu Lys Gly Thr 
     50                  55                  60
Ser Lys Glu Asp Ala Met Lys Ala Tyr Ile Asn Lys Val Glu Glu Leu 
 65                  70                  75                  80
Lys Lys Lys Tyr Gly Ile 
                 85



<210> 6556
<211> 497
<212> DNA
<213> Rattus norvegicus
<308> AI010581
<400> 6556

agagtaaca  atgtacttt  aattgattt  aggtaaaaa  tccaaagga  ggaggagca  60
taattaact  tggccctaa  atatcagag  catgtcatc  acattagaa  aaaaaaaaa  120
caccaaggc  ttatgtcct  acaggtatt  tgtcacaca  gtggctggc  accaaatct  180
gtcgtttat  ttccatatt  cttctttag  tcttctacc  tttccacat  ggtcttcat  240
gcattttcc  tggaagttc  tttcagctt  ttccacgag  cccacttgg  tttgccctt  300
aggtccaac  gccccggcc  atctgtgtt  acatcgccc  cagtagctt  tttgaagtg  360
ctgtagatg  acagcatct  ttcatcagt  ggctgagtc  tgaggcgct  cacctcctc  420
gcggctttg  caaaatcag  ctgagacat  ctggcgagg  gacctggat  ctgaaagcg  480
gggagcaag  tcagaag  497



<210> 6557
<211> 86
<212> PRT
<213> Rattus norvegicus
<308> P11030
<400> 6557

Ser Gln Ala Asp Phe Asp Lys Ala Ala Glu Glu Val Lys Arg Leu Lys 
  1               5                  10                  15
Thr Gln Pro Thr Asp Glu Glu Met Leu Phe Ile Tyr Ser His Phe Lys 
             20                  25                  30
Gln Ala Thr Val Gly Asp Val Asn Thr Asp Arg Pro Gly Leu Leu Asp 
         35                  40                  45
Leu Lys Gly Lys Ala Lys Trp Asp Ser Trp Asn Lys Leu Lys Gly Thr 
     50                  55                  60
Ser Lys Glu Asn Ala Met Lys Thr Tyr Val Glu Lys Val Glu Glu Leu 
 65                  70                  75                  80
Lys Lys Lys Tyr Gly Ile 
                 85



<210> 6558
<211> 1156
<212> DNA
<213> Homo sapiens
<308> BC000920
<400> 6558

caggccgca  ccctctgtt  caggaaacc  ttgggctta  gcctcactt  ctggtcctc  60
acaagatgg  cttggcgga  cttacagag  agcagaaaa  tatgcaaca  ttagaagga  120
aaggcctaa  aaatgtcat  tttaccaac  gtgtaaagg  tgaaaatgt  aagcagatc  180
tcccgatgg  cactgaact  attgggaga  gccaccgct  ccaccgaaa  gagaacctg  240
agtactgta  catggtcat  ggggtcccc  acgtgggca  gtcctccct  atcaactcc  300
tccggaggc  gcacctcag  aaagggaaa  ccaccaggg  gggtggcga  cctgggatc  360
ccagagctg  gatgtccaa  attcaggtc  ctgagcggc  cctgatgtt  ctgttggac  420
ctcctggcg  gctggctcc  cggattgaa  gtgtggaga  aggcctgaa  ctggccctg  480
gtggaacgg  gctggacca  ctggtcggg  aggagacca  ggctgacta  ctgctgtac  540
ccctcaaca  acaccagcg  tttgggtac  tgcagcact  cggcctggg  agtgcctgt  600
acaacgtag  gcgcgtgct  aagagtgtg  ctgtgaagc  ggggaagac  cagaaggtg  660
aggtgctca  gggcacggg  aacgtgaac  ttattcagc  taactatcc  gcggcagcc  720
gtgacttcc  gcagacttt  cgccgtggg  tgctgggtt  cgtgatgct  gacctcgac  780
tcctgcggg  ccacccccc  gctgagact  tgccctgaa  ttgtccggg  agggagggc  840
ggaggcatg  ggcctccca  acctcctga  ctgggtggt  gaggctcaa  acagctcac  900
cggtccaga  gctccatgc  ggtcactag  gtgctgtgc  ctctggcgc  ccacagcct  960
gccagctcc  gggacccca  ttgcagggg  caagcaggt  ggagtggac  ccaggcttc  1020
cagtggacg  ccctgagca  ctccgcatg  ttggttctc  cggagcttc  tgctcaggc  1080
tcttgagaa  tggatgctg  ctcagaagg  gttaaagct  taacctgta  cctttaaaa  1140
aaaaaaaaa  aaaaaa  1156



<210> 6559
<211> 86
<212> PRT
<213> Homo sapiens
<308> NZHU
<400> 6559

Ser Gln Ala Glu Phe Glu Lys Ala Ala Glu Glu Val Arg His Leu Lys 
  1               5                  10                  15
Thr Lys Pro Ser Asp Glu Glu Met Leu Phe Ile Tyr Gly His Tyr Lys 
             20                  25                  30
Gln Ala Thr Val Gly Asp Ile Asn Thr Glu Arg Pro Gly Met Leu Asp 
         35                  40                  45
Phe Thr Gly Lys Ala Lys Trp Asp Ala Trp Asn Glu Leu Lys Gly Thr 
     50                  55                  60
Ser Lys Glu Asp Ala Met Lys Ala Tyr Ile Asn Lys Val Glu Glu Leu 
 65                  70                  75                  80
Lys Lys Lys Tyr Gly Ile 
                 85



<210> 6560
<211> 644
<212> DNA
<213> Rattus norvegicus
<308> AI011498
<400> 6560

accaataaa  aaaaagatt  atttggaat  ttccaagtt  gccagaagt  gcatttgcc  60
agccttagg  ccaccctct  taagaccaa  tgcaaaagg  aacaacaga  ctccagctt  120
ccccttccc  tgcagagtg  acgcacaca  gtacgcccc  tctttagct  ggttagaga  180
ctggcacat  cccaccctc  ggaggttcc  cctccccct  ctcaatcag  tatgggtgg  240
cagccccat  gcatccagg  gatgatggc  gctgcagcc  cttgcatag  ttaagaaaa  300
aaaataagg  aggaggcac  aagtgggct  cctgaaaaa  cccgttacc  ctgtacaaa  360
aagtggctc  cacatagaa  aacctgctc  ccaaatagt  caaataccc  aagagaagg  420
caaccagca  caaggctgg  cttgtagga  tggcaaaga  ctttggttg  gaaaggcca  480
gaagagtct  ggctgggcc  actcttcct  gcccagctc  ccaaagcca  ctctgacac  540
ggccctagg  tggagcctg  aaacatgca  acccagcag  ctttggttc  gaaatgtct  600
ttacaaagt  aaaagcaca  ccttcagca  tcctacctg  gcct  644



<210> 6561
<211> 531
<212> PRT
<213> Rattus norvegicus
<308> BAA24106
<400> 6561

Met Ser Gly Arg Gly Ala Gly Gly Phe Pro Leu Pro Pro Leu Ser Pro 
  1               5                  10                  15
Gly Gly Gly Ala Val Ala Ala Ala Leu Gly Ala Pro Pro Pro Pro Ala 
             20                  25                  30
Gly Pro Gly Met Leu Pro Asn Pro Ala Leu Arg Gly Pro Gly Pro Ser 
         35                  40                  45
Gly Gly Met Gly Val Pro Gly Ala Ala Ala Phe Arg Pro Met Gly Pro 
     50                  55                  60
Ala Gly Pro Ala Ala Gln Tyr Gln Arg Pro Gly Met Ser Pro Gly Ser 
 65                  70                  75                  80
Arg Met Pro Met Ala Gly Leu Gln Val Gly Pro Pro Ala Gly Ser Pro 
                 85                  90                  95
Phe Gly Thr Ala Ala Pro Leu Arg Pro Gly Met Pro Pro Thr Met Met 
             100                105                110
Asp Pro Phe Arg Lys Arg Leu Leu Val Pro Gln Ala Gln Pro Pro Met 
         115                120                125
Pro Ala Gln Arg Arg Gly Leu Lys Arg Arg Lys Met Ala Asp Lys Val 
     130                135                140
Leu Pro Gln Arg Ile Arg Glu Leu Val Pro Glu Ser Gln Ala Tyr Met 
 145                150                155                160
Asp Leu Leu Ala Phe Glu Arg Lys Leu Asp Gln Thr Ile Ala Arg Lys 
                 165                170                175
Arg Met Glu Ile Gln Glu Ala Ile Lys Lys Pro Leu Thr Gln Lys Arg 
             180                185                190
Lys Leu Arg Ile Tyr Ile Ser Asn Thr Phe Ser Pro Ser Lys Ala Asp 
         195                200                205
Gly Asp Asn Ser Gly Thr Ala Gly Thr Pro Gly Gly Thr Pro Ala Ala 
     210                215                220
Asp Lys Val Ala Ser Trp Glu Leu Arg Val Glu Gly Lys Leu Leu Asp 
 225                230                235                240
Asp Pro Ser Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu 
                 245                250                255
Val Ile Glu Leu Asp Lys Glu Leu Tyr Gly Pro Asp Asn His Leu Val 
             260                265                270
Glu Trp His Arg Met Pro Thr Thr Gln Glu Thr Asp Gly Phe Gln Val 
         275                280                285
Lys Arg Pro Gly Asp Leu Asn Val Lys Cys Thr Leu Leu Leu Met Leu 
     290                295                300
Asp His Gln Pro Pro Gln Tyr Lys Leu Asp Pro Arg Leu Ala Arg Leu 
 305                310                315                320
Leu Gly Val His Thr Gln Thr Arg Ala Ala Ile Met Gln Ala Leu Trp 
                 325                330                335
Leu Tyr Ile Lys His Asn Gln Leu Gln Asp Gly His Glu Arg Glu Tyr 
             340                345                350
Ile Asn Cys Asn Arg Tyr Phe Arg Gln Ile Phe Ser Cys Gly Arg Leu 
         355                360                365
Arg Phe Ser Glu Ile Pro Met Lys Leu Ala Gly Leu Leu Gln His Pro 
     370                375                380
Asp Pro Ile Val Ile Asn His Val Ile Ser Val Asp Pro Asn Asp Gln 
 385                390                395                400
Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Asp Asp Pro Leu 
                 405                410                415
Lys Ala Gln Met Ser Asn Phe Leu Ala Ser Thr Thr Asn Gln Gln Glu 
             420                425                430
Ile Ala Ser Leu Asp Val Lys Ile His Glu Thr Ile Glu Ser Ile Asn 
         435                440                445
Gln Leu Lys Thr Gln Arg Asp Phe Met Leu Ser Phe Ser Thr Glu Pro 
     450                455                460
Gln Asp Phe Ile Gln Glu Trp Leu Arg Ser Gln Arg Arg Asp Leu Lys 
 465                470                475                480
Ile Ile Thr Asp Val Ile Gly Asn Pro Glu Glu Glu Arg Arg Ala Ala 
                 485                490                495
Phe Tyr His Gln Pro Trp Ala Gln Glu Ala Val Gly Arg His Ile Phe 
             500                505                510
Ala Lys Val Gln Gln Arg Arg Gln Glu Leu Glu Gln Val Leu Gly Ile 
         515                520                525
Arg Leu Thr 
     530



<210> 6562
<211> 1121
<212> DNA
<213> Homo sapiens
<308> BC018953
<400> 6562

ggcacgagg  gagatttca  gctcagttt  agcaccgac  cccaggact  catccagga  60
tggctccgt  cccagcgcc  agacctcaa  atcatcact  atgtgattg  aaatcctga  120
gaggagaga  gagctgctt  ctaccacca  ccctgggcc  aggaagcag  aggcaggca  180
atctttgcc  aggtgcagc  gcgaaggca  gaactggaa  aggtgctgg  aattcgcct  240
acctaactg  tcagggatc  ttcttccca  ccctggagc  tggagggag  ccaccctct  300
ggtccttgc  ggggccgca  acacgtagg  tggggtgag  agtgtctgc  gtcaccctc  360
actctccag  tttagtttt  taaatgtag  gataggatt  cttgttgct  ggtccccaa  420
gccttatac  ttttgcatt  gctttaatt  ggttcagca  atgcctcct  tgcccccct  480
caggcaggc  caagtagga  tgctggagg  tgtgctttg  cattgtaag  catttccga  540
ccaaaggct  ctgggtttg  atgtttaca  actccccct  gggcgaggg  cagagctgg  600
tctggggag  tgggctagg  agaggaggt  cagcccaga  tcttcctag  ctttctaaa  660
caaagttct  tgccattcc  acaagccca  ccttgctgc  ggttttttc  tttcctttg  720
gtatttgca  tattttggg  gcaagtttt  tatgtggga  ccacttttt  tgtacaggg  780
taagttggg  gttttcagg  agcctgtta  gtgcctcct  cttttcttt  ctcaatcta  840
gcaagcggc  ctggccgcc  tcatctcct  ggatgccag  gggctgcct  tccagcggc  900
tgggccggg  aggggacac  ccagttctc  agcatggcc  gaggtatgg  gtatgtgca  960
gtggaggcc  gggtaaggt  aatggggag  ctgggagga  tggtgttgc  ctttggagc  1020
tggtgagga  ggtgggcct  gggcttggc  agtgccaca  ctggcaggt  tggaaattt  1080
caaataaat  cttttgtct  aaaaaaaaa  aaaaaaaaa  a  1121



<210> 6563
<211> 531
<212> PRT
<213> Homo sapiens
<308> XP_008253
<400> 6563

Met Ser Gly Arg Gly Ala Gly Gly Phe Pro Leu Pro Pro Leu Ser Pro 
  1               5                  10                  15
Gly Gly Gly Ala Val Ala Ala Ala Leu Gly Ala Pro Pro Pro Pro Ala 
             20                  25                  30
Gly Pro Gly Met Leu Pro Gly Pro Ala Leu Arg Gly Pro Gly Pro Ala 
         35                  40                  45
Gly Gly Val Gly Gly Pro Gly Ala Ala Ala Phe Arg Pro Met Gly Pro 
     50                  55                  60
Ala Gly Pro Ala Ala Gln Tyr Gln Arg Pro Gly Met Ser Pro Gly Asn 
 65                  70                  75                  80
Arg Met Pro Met Ala Gly Leu Gln Val Gly Pro Pro Ala Gly Ser Pro 
                 85                  90                  95
Phe Gly Ala Ala Ala Pro Leu Arg Pro Gly Met Pro Pro Thr Met Met 
             100                105                110
Asp Pro Phe Arg Lys Arg Leu Leu Val Pro Gln Ala Gln Pro Pro Met 
         115                120                125
Pro Ala Gln Arg Arg Gly Leu Lys Arg Arg Lys Met Ala Asp Lys Val 
     130                135                140
Leu Pro Gln Arg Ile Arg Glu Leu Val Pro Glu Ser Gln Ala Tyr Met 
 145                150                155                160
Asp Leu Leu Ala Phe Glu Arg Lys Leu Asp Gln Thr Ile Ala Arg Lys 
                 165                170                175
Arg Met Glu Ile Gln Glu Ala Ile Lys Lys Pro Leu Thr Gln Lys Arg 
             180                185                190
Lys Leu Arg Ile Tyr Ile Ser Asn Thr Phe Ser Pro Ser Lys Ala Glu 
         195                200                205
Gly Asp Ser Ala Gly Thr Ala Gly Thr Pro Gly Gly Thr Pro Ala Gly 
     210                215                220
Asp Lys Val Ala Ser Trp Glu Leu Arg Val Glu Gly Lys Leu Leu Asp 
 225                230                235                240
Asp Pro Ser Lys Gln Lys Arg Lys Phe Ser Ser Phe Phe Lys Ser Leu 
                 245                250                255
Val Ile Glu Leu Asp Lys Glu Leu Tyr Gly Pro Asp Asn His Leu Val 
             260                265                270
Glu Trp His Arg Met Pro Thr Thr Gln Glu Thr Asp Gly Phe Gln Val 
         275                280                285
Lys Arg Pro Gly Asp Leu Asn Val Lys Cys Thr Leu Leu Leu Met Leu 
     290                295                300
Asp His Gln Pro Pro Gln Tyr Lys Leu Asp Pro Arg Leu Ala Arg Leu 
 305                310                315                320
Leu Gly Val His Thr Gln Thr Arg Ala Ala Ile Met Gln Ala Leu Trp 
                 325                330                335
Leu Tyr Ile Lys His Asn Gln Leu Gln Asp Gly His Glu Arg Glu Tyr 
             340                345                350
Ile Asn Cys Asn Arg Tyr Phe Arg Gln Ile Phe Ser Cys Gly Arg Leu 
         355                360                365
Arg Phe Ser Glu Ile Pro Met Lys Leu Ala Gly Leu Leu Gln His Pro 
     370                375                380
Asp Pro Ile Val Ile Asn His Val Ile Ser Val Asp Pro Asn Asp Gln 
 385                390                395                400
Lys Lys Thr Ala Cys Tyr Asp Ile Asp Val Glu Val Asp Asp Pro Leu 
                 405                410                415
Lys Ala Gln Met Ser Asn Phe Leu Ala Ser Thr Thr Asn Gln Gln Glu 
             420                425                430
Ile Ala Ser Leu Asp Val Lys Ile His Glu Thr Ile Glu Ser Ile Asn 
         435                440                445
Gln Leu Lys Thr Gln Arg Asp Phe Met Leu Ser Phe Ser Thr Asp Pro 
     450                455                460
Gln Asp Phe Ile Gln Glu Trp Leu Arg Ser Gln Arg Arg Asp Leu Lys 
 465                470                475                480
Ile Ile Thr Asp Val Ile Gly Asn Pro Glu Glu Glu Arg Arg Ala Ala 
                 485                490                495
Phe Tyr His Gln Pro Trp Ala Gln Glu Ala Val Gly Arg His Ile Phe 
             500                505                510
Ala Lys Val Gln Gln Arg Arg Gln Glu Leu Glu Gln Val Leu Gly Ile 
         515                520                525
Arg Leu Thr 
     530



<210> 6564
<211> 405
<212> DNA
<213> Rattus norvegicus
<308> AI011556
<400> 6564

cacacggag  tgctcggtc  cagagaagg  acttaatta  gaaggtcat  taatcccgg  60
caaccatat  ctctccctt  accaactcc  ttggcactt  tttgtgggt  cacttaacc  120
tcataatct  gggagagag  ctaagggct  gaactccag  ctcagcagg  atgggagtg  180
gtaatttgc  cgcctgctg  cttccttgg  tgtggtagc  gtttctcag  ctccctctc  240
ggaatcgaa  cctgattcc  cgtcacccg  ggtcaccat  gtaggcacg  cgactacca  300
cgaaagttg  tagggcaga  gttcgaatg  gtcgtcgcc  ccacggagg  cgtgcgatc  360
gcccgaggt  atctagagt  accaaagcc  ccggcgccc  accca  405



<210> 6565
<211> 1869
<212> DNA
<213> Homo sapiens
<308> X03205
<400> 6565

tacctggtt  atcctgcca  tagcatatg  ttgtctcaa  gattaagcc  tgcatgtct  60
agtacgcac  gccggtaca  tgaaactgc  aatggctca  taaatcagt  atggttcct  120
tggtcgctc  ctcctctcc  acttggata  ctgtggtaa  tctagagct  atacatgcc  180
acgggcgct  acccccttc  cggggggga  gcgtgcatt  atcagatca  aaccaaccc  240
gtcagcccc  ctccggccc  ggccggggg  cgggcgccg  cggctttgg  gactctaga  300
aacctcggg  cgatcgcac  ccccccgtg  cggcgacga  ccattcgaa  gtctgccct  360
tcaactttc  atggtagtc  ccgtgccta  catggtgac  acgggtgac  gggaatcag  420
gttcgattc  ggagaggga  cctgagaaa  ggctaccac  tccaaggaa  gcagcaggc  480
cgcaaatta  ccactcccg  cccggggag  tagtgacga  aaataacaa  acaggactc  540
ttcgaggcc  tgtaattgg  atgagtcca  tttaaatcc  ttaacgagg  tccattgga  600
ggcaagtct  gtgccagca  ccgcggtaa  tccagctcc  atagcgtat  ttaaagttg  660
tgcagttaa  aagctcgta  ttggatctt  ggagcgggc  ggcggtccg  cgcgaggcg  720
gccaccgcc  gtccccgcc  cttgcctct  ggcgccccc  cgatgctct  agctgagtg  780
cccgcgggg  ccgaagcgt  tactttgaa  aaattagag  gttcaaagc  ggcccgagc  840
gcctggata  cgcagctag  aataatgga  taggaccgc  gttctattt  gttggtttt  900
ggaactgag  ccatgatta  gagggacgg  cgggggcat  cgtattgcg  cgctagagg  960
gaaattctt  gaccggcgc  agacggacc  gagcgaaag  atttgccaa  aatgttttc  1020
ttaatcaag  acgaaagtc  gaggttcga  gacgatcag  taccgtcgt  gttccgacc  1080
taaacgatg  cgaccggcg  tgcggcggc  ttattccca  gacccgccg  gcagcttcc  1140
ggaaaccaa  gtctttggg  tccgggggg  gtatggttg  aaagctgaa  cttaaagga  1200
ttgacggaa  ggcaccacc  ggagtggag  ctgcggctt  atttgactc  acacgggaa  1260
cctcacccg  cccggacac  gacaggatt  acagattga  agctctttc  cgattccgt  1320
ggtggtggt  catggccgt  cttagttgg  ggagcgatt  gtctggtta  ttccgataa  1380
gaacgagac  ctggcatgc  aactagtta  gcgaccccc  agcggtcgg  gtcccccaa  1440
ttcttagag  gacaagtgg  gttcagcca  ccgagattg  gcaataaca  gtctgtgat  1500
cccttagat  tccggggct  cacgcgcgc  acactgact  gctcagcgt  tgcctaccc  1560
acgccggca  gcgcgggta  cccgttgaa  cccattcgt  atggggatc  gggattgca  1620
ttattcccc  tgaacgagg  attcccagt  agtgcgggt  ataagcttg  gttgattaa  1680
tccctgccc  ttgtacaca  cgcccgtcg  tactaccga  tggatggtt  agtgaggcc  1740
tcggatcgg  cccgccggg  tcggcccac  gccctggcg  agcgctgag  agacggtcg  1800
acttgacta  ctagaggaa  taaaagtcg  aacaaggtt  ccgtaggtg  acctgcgga  1860
ggatcatta  1869



<210> 6566
<211> 495
<212> DNA
<213> Rattus norvegicus
<308> AI011998
<400> 6566

cactcacac  caatattgt  tgagacatt  ctagttttc  tatgcatcc  taggattaa  60
actcatatg  agtataaca  ggaaaagtg  agaactaaa  aaataactc  aacaacaaa  120
gaagcacac  tttcttaaa  tttaaaaat  ttgcacata  taaggttgc  cagaaatta  180
tggctgctt  tacaaaaag  atgaggtat  agtcaatct  tagataaag  taagtgcaa  240
agagtaact  cacacacac  caccaaaaa  aaaaaacaa  ttcatacga  gacctagaa  300
gtcaacana  aaaaatatt  aaaaagaag  ttacaaagc  atgattttg  tcatacaaa  360
tcattagcc  attactaaa  cacaatttc  tggcaatag  ttataaatt  taaactttc  420
tcagcttaa  tacgtgcaa  acaatcatc  ccatcacac  aattctcct  tagaagagg  480
atctttctg  gatag  495



<210> 6567
<211> 222
<212> PRT
<213> Rattus norvegicus
<308> P97554
<400> 6567

Met Ala Thr Pro Gln Ser Val Phe Val Phe Ala Ile Cys Ile Leu Met 
  1               5                  10                  15
Ile Thr Glu Leu Ile Leu Ala Ser Lys Asn Tyr Tyr Asp Ile Leu Gly 
             20                  25                  30
Val Pro Lys Ser Ala Ser Glu Arg Gln Ile Lys Lys Ala Phe His Lys 
         35                  40                  45
Leu Ala Met Lys Tyr His Pro Asp Lys Asn Lys Ser Pro Asp Ala Glu 
     50                  55                  60
Ala Lys Phe Arg Glu Ile Ala Glu Ala Tyr Glu Thr Leu Ser Asp Ala 
 65                  70                  75                  80
Asn Arg Arg Lys Glu Tyr Asp Ile Ile Gly His Ser Ala Phe Thr Asn 
                 85                  90                  95
Gly Lys Gly Gln Arg Ser Asn Gly Ser Pro Phe Glu Gln Ser Phe Asn 
             100                105                110
Phe Asn Phe Asp Asp Leu Phe Lys Asp Phe Asn Leu Phe Gly Gln Asn 
         115                120                125
Gln Asn Thr Arg Ser Lys Lys His Phe Glu Asn His Phe Gln Thr Arg 
     130                135                140
Gln Asp Gly Ser Ser Arg Gln Arg His His Phe Gln Glu Phe Ser Phe 
 145                150                155                160
Gly Gly Gly Leu Phe Asp Asp Met Phe Glu Asp Met Glu Lys Met Phe 
                 165                170                175
Ser Phe Ser Gly Phe Asp Ser Thr Asn Arg Arg Thr Val Gln Thr Glu 
             180                185                190
Asn Arg Phe His Gly Ser Ser Lys His Cys Arg Thr Val Thr Gln Arg 
         195                200                205
Arg Gly Asn Met Val Thr Thr Tyr Thr Asp Cys Ser Gly Gln 
     210                215                220



<210> 6568
<211> 2371
<212> DNA
<213> Homo sapiens
<308> NM_012328
<400> 6568

agctggctg  gaggggact  ggcgccggc  gggaaggag  agcgctagg  cggtgtacg  60
ccgagatta  ggtgcgtgc  agctccggg  ggccgcggt  aggggccgg  cccaagctg  120
cgacccgag  cgatcgtca  ggtcgccag  gcctcagct  tgtggagga  cagcagtag  180
cggagggtg  aggatatta  aaatggcta  tccccagtc  attttcatc  ttgcaatct  240
cattttaat  ataacagaa  taattctgg  ctcaaaaag  tactatgat  tcttaggtg  300
gccaaaatc  gcatcagag  gccaaatca  gaaggcctt  cacaagttg  ccatgaagt  360
ccaccctga  aaaaataag  gcccggatg  tgaagcaaa  ttcagagag  ttgcagaag  420
atatgaaac  ctctcagat  ctaatagac  aaaagagta  gatacactt  gacacagtg  480
ttttactag  ggtaaagga  aaagaggta  tggaagttc  tttgagcag  catttaact  540
caattttga  gacttattt  aagactttg  cttttttgg  caaaaccaa  acactggat  600
caagaagcg  tttgaaaat  atttccaga  acgccagga  ggtggttcc  gtagacaaa  660
gcatcattt  caagaattt  cttttggag  tggattatt  gatgacatg  ttgaagata  720
ggagaaaat  ttttctttt  gtggttttg  ctctaccaa  cagcataca  tacagactg  780
aaatagatt  catggatct  gcaagcact  caggactgt  actcaacga  gaggaaata  840
ggttactac  tacactgac  gttcaggac  gtagttctt  ttctattct  actaaatcc  900
actggttga  tcttcctca  tatctttga  gctaaacaa  tttctgtga  ctattttga  960
aagtgcatg  tttcacttt  aacaatttg  tatagctat  aaatatatt  aagggtttt  1020
tttttttga  aaattcaac  ttcaacgag  agacaaaat  ctaattatt  ccctgatta  1080
gaaagtttc  ttaaaaaac  cgtaatttt  cctagtgct  tttctctac  tgcccttgg  1140
ctcactaat  tcaccagta  tattaccaa  aaaatattg  gtttacctg  ttaaacttt  1200
aaagttaat  gtagattta  attgtgtga  cctaatgat  tttgcagtg  aacctttac  1260
aattcaaag  tgcatgttc  atgacatct  tgacttgcg  tgcagagtg  acatgaaac  1320
gtataattg  gtcattcag  aaaggagaa  agtatcttg  ttaattgct  ctgaaaggt  1380
gagaaagga  tggtttgat  tttaccaca  cgctgtgcc  ttctacagt  gaactgggg  1440
aaaggaaat  gttttattg  ccatagtca  ttaggctgg  aaaaagttg  aaacttaac  1500
aaatattgc  aagagattg  tatgtgttt  gttccagcc  aaaaatgat  ttgtagtgt  1560
gaaatcata  ctacttaca  agctttttc  tatttcttt  ttagttgtt  gcactctta  1620
gtcttagta  ggatttatg  gtttgtgtg  gtgtagttt  tcctctctc  catctttat  1680
tagagattg  ctgatacct  attctgttt  taaaaccag  cagtaattt  tgtgcaacc  1740
tactatgtg  aatattttt  aatcctgag  aatgtgtgc  tttgttttc  gatagactt  1800
tttctttag  tctgcactt  tccacatta  actccatat  agtattaat  ctatggata  1860
atattaaaa  aagtgtctc  tacaacatt  tatgtgaga  aaatataaa  atttacaac  1920
tgatattcg  tgttgtttt  ttgttaaaa  tttattatg  aactctgga  gtatagagg  1980
catataagc  atgggacat  tgctgatca  aggctatat  catgaagtt  cttttgacc  2040
acctgaaaa  tgataggat  ttgtttgtc  tttggtaat  tctactgca  tcttaccat  2100
cttctctca  aaattttga  agcttgaag  tctttttaa  tataatttt  ttgtatttg  2160
ttcctagga  caagtgttc  tgctgccag  tctttcctc  ttaggcgtg  ttgagaaaa  2220
gcagaaact  tacataaag  tgtatttct  aatcatctt  aatttgaaa  ttaagaaaa  2280
gaatttatt  tgttatatt  atgtaactt  tttcctgga  gttatatct  ctagttttg  2340
ttgataata  taaaattag  tataccttg  a  2371



<210> 6569
<211> 223
<212> PRT
<213> Homo sapiens
<308> Q9UBS3
<400> 6569

Met Ala Thr Pro Gln Ser Ile Phe Ile Phe Ala Ile Cys Ile Leu Met 
  1               5                  10                  15
Ile Thr Glu Leu Ile Leu Ala Ser Lys Ser Tyr Tyr Asp Ile Leu Gly 
             20                  25                  30
Val Pro Lys Ser Ala Ser Glu Arg Gln Ile Lys Lys Ala Phe His Lys 
         35                  40                  45
Leu Ala Met Lys Tyr His Pro Asp Lys Asn Lys Ser Pro Asp Ala Glu 
     50                  55                  60
Ala Lys Phe Arg Glu Ile Ala Glu Ala Tyr Glu Thr Leu Ser Asp Ala 
 65                  70                  75                  80
Asn Arg Arg Lys Glu Tyr Asp Thr Leu Gly His Ser Ala Phe Thr Ser 
                 85                  90                  95
Gly Lys Gly Gln Arg Gly Ser Gly Ser Ser Phe Glu Gln Ser Phe Asn 
             100                105                110
Phe Asn Phe Asp Asp Leu Phe Lys Asp Phe Gly Phe Phe Gly Gln Asn 
         115                120                125
Gln Asn Thr Gly Ser Lys Lys Arg Phe Glu Asn His Phe Gln Thr Arg 
     130                135                140
Gln Asp Gly Gly Ser Ser Arg Gln Arg His His Phe Gln Glu Phe Ser 
 145                150                155                160
Phe Gly Gly Gly Leu Phe Asp Asp Met Phe Glu Asp Met Glu Lys Met 
                 165                170                175
Phe Ser Phe Ser Gly Phe Asp Ser Thr Asn Gln His Thr Val Gln Thr 
             180                185                190
Glu Asn Arg Phe His Gly Ser Ser Lys His Cys Arg Thr Val Thr Gln 
         195                200                205
Arg Arg Gly Asn Met Val Thr Thr Tyr Thr Asp Cys Ser Gly Gln 
     210                215                220



<210> 6570
<211> 482
<212> DNA
<213> Rattus norvegicus
<308> AI012030
<400> 6570

gaaagtatc  aaccagaat  ttattatat  taaacacat  tcttaatac  gctctttca  60
tactttcaa  ccgcggaag  aaggagtgg  ccagccaga  agaagatca  gtgaggaac  120
agcaacgca  acgaatctg  gtatcggta  tgctactgc  ggggaatat  aaaccagac  180
ccgtaacaa  gcgactgtt  ccttgcgct  ttatttggc  cctcggcgc  gcctgaagt  240
gcggttgta  gcggcgttg  acccgtaga  cagggcgta  cgctcacac  gcttgtagt  300
atcacaggc  tccctgttg  tctcctgng  aggcttgtt  agttcccgg  ctctttcct  360
ggctttagc  tgccatctc  gctgagggg  tataaaggt  ttggcattt  tccggttgg  420
gaagggact  acttcatag  attccatgc  ttcgtgaga  tcatagcac  gggctgcca  480
gg  482



<210> 6571
<211> 103
<212> PRT
<213> Rattus norvegicus
<308> P08494
<400> 6571

Met Lys Ser Leu Leu Pro Leu Ala Ile Leu Ala Ala Leu Ala Val Ala 
  1               5                  10                  15
Ala Leu Cys Tyr Glu Ser His Glu Ser Met Glu Ser Tyr Glu Val Ser 
             20                  25                  30
Pro Phe Thr Thr Arg Arg Asn Ala Asn Thr Phe Ile Ser Pro Gln Gln 
         35                  40                  45
Arg Trp His Ala Lys Ala Gln Glu Arg Val Arg Glu Leu Asn Lys Pro 
     50                  55                  60
Ala Gln Glu Ile Asn Arg Glu Ala Cys Asp Asp Tyr Lys Leu Cys Glu 
 65                  70                  75                  80
Arg Tyr Ala Leu Ile Tyr Gly Tyr Asn Ala Ala Tyr Asn Arg Tyr Phe 
                 85                  90                  95
Arg Gln Arg Arg Gly Ala Lys 
             100



<210> 6572
<211> 603
<212> DNA
<213> Homo sapiens
<308> NM_000900
<400> 6572

cgtgctgct  cacaagaac  ctgagactg  cctgcagga  gaaaccatg  agagcctga  60
ccttcttgc  atcctggcc  ccttagcgg  agtaacttt  tgttatgaa  cacatgaaa  120
catggaatc  tatgaactt  atcccttca  taacaggag  aatgcaaat  ccttcatat  180
ccctcagca  agatggaga  ctaaagtcc  agagaggat  cgagaacgc  ctaagcctg  240
ccacgagct  aatagggaa  cctgtgatg  ctacagact  tgcgaacgc  acgccatgg  300
ttatggata  aatgctgcc  ataatcgct  cttcaggaa  cgccgaggg  ccaaatgag  360
ctgagggaa  aaaaaaaat  tcttttttt  tggaggctg  cacctgatt  tgtatcccc  420
tgtagcagc  ttactgaaa  acataggct  atatacaat  cttctttcc  gtatattct  480
ttgtctggc  gcacccctt  ttcccgccc  cagattgat  agtaatgaa  gtgcactgc  540
gtgagggtc  aaggagagt  aacatatgt  attgttcca  aataaactt  tggtgtgat  600
ctt  603



<210> 6573
<211> 103
<212> PRT
<213> Homo sapiens
<308> P08493
<400> 6573

Met Lys Ser Leu Ile Leu Leu Ala Ile Leu Ala Ala Leu Ala Val Val 
  1               5                  10                  15
Thr Leu Cys Tyr Glu Ser His Glu Ser Met Glu Ser Tyr Glu Leu Asn 
             20                  25                  30
Pro Phe Ile Asn Arg Arg Asn Ala Asn Thr Phe Ile Ser Pro Gln Gln 
         35                  40                  45
Arg Trp Arg Ala Lys Val Gln Glu Arg Ile Arg Glu Arg Ser Lys Pro 
     50                  55                  60
Val His Glu Leu Asn Arg Glu Ala Cys Asp Asp Tyr Arg Leu Cys Glu 
 65                  70                  75                  80
Arg Tyr Ala Met Val Tyr Gly Tyr Asn Ala Ala Tyr Asn Arg Tyr Phe 
                 85                  90                  95
Arg Lys Arg Arg Gly Ala Lys 
             100



<210> 6575
<211> 414
<212> PRT
<213> Rattus norvegicus
<308> O09018
<400> 6575

Met Ala Met Val Val Ser Thr Trp Arg Asp Pro Gln Asp Glu Val Pro 
  1               5                  10                  15
Gly Ser Gln Gly Ser Gln Ala Ser Gln Ala Pro Pro Val Pro Gly Pro 
             20                  25                  30
Pro Pro Gly Ala Pro His Thr Pro Gln Thr Pro Gly Gln Gly Gly Pro 
         35                  40                  45
Ala Ser Thr Pro Ala Gln Thr Ala Ala Gly Ser Gln Gly Gly Pro Gly 
     50                  55                  60
Gly Pro Gly Ser Asp Lys Gln Gln Gln Gln Gln His Ile Glu Cys Val 
 65                  70                  75                  80
Val Cys Gly Asp Lys Ser Ser Gly Lys His Tyr Gly Gln Phe Thr Cys 
                 85                  90                  95
Glu Gly Cys Lys Ser Phe Phe Lys Arg Ser Val Arg Arg Asn Leu Ser 
             100                105                110
Tyr Thr Cys Arg Ala Asn Arg Asn Cys Pro Ile Asp Gln His His Arg 
         115                120                125
Asn Gln Cys Gln Tyr Cys Arg Leu Lys Lys Cys Leu Lys Val Gly Met 
     130                135                140
Arg Arg Glu Ala Val Gln Arg Gly Arg Met Pro Pro Thr Gln Pro Thr 
 145                150                155                160
His Gly Gln Phe Ala Leu Thr Asn Gly Asp Pro Leu Asn Cys His Ser 
                 165                170                175
Tyr Leu Ser Gly Tyr Ile Ser Leu Leu Leu Arg Ala Glu Pro Tyr Pro 
             180                185                190
Thr Ser Arg Phe Gly Ser Gln Cys Met Gln Pro Asn Asn Ile Met Gly 
         195                200                205
Ile Glu Asn Ile Cys Glu Leu Ala Ala Arg Met Leu Phe Ser Ala Val 
     210                215                220
Glu Trp Ala Arg Asn Ile Pro Phe Phe Pro Asp Leu Gln Ile Thr Asp 
 225                230                235                240
Gln Val Ala Leu Leu Arg Leu Thr Trp Ser Glu Leu Phe Val Leu Asn 
                 245                250                255
Ala Ala Gln Cys Ser Met Pro Leu His Val Ala Pro Leu Leu Ala Ala 
             260                265                270
Ala Gly Leu His Ala Ser Pro Met Ser Ala Asp Arg Val Val Ala Phe 
         275                280                285
Met Asp His Ile Arg Ile Phe Gln Glu Gln Val Glu Lys Leu Lys Ala 
     290                295                300
Leu His Val Asp Ser Ala Glu Tyr Ser Cys Leu Lys Ala Ile Val Leu 
 305                310                315                320
Phe Thr Ser Asp Ala Cys Gly Leu Ser Asp Val Ala His Val Glu Ser 
                 325                330                335
Leu Gln Glu Lys Ser Gln Cys Ala Leu Glu Glu Tyr Val Arg Ser Gln 
             340                345                350
Tyr Pro Asn Gln Pro Thr Arg Phe Gly Lys Leu Leu Leu Arg Leu Pro 
         355                360                365
Ser Leu Arg Thr Val Ser Ser Ser Val Ile Glu Gln Leu Phe Phe Val 
     370                375                380
Arg Leu Val Gly Lys Thr Pro Ile Glu Thr Leu Ile Arg Asp Met Leu 
 385                390                395                400
Leu Ser Gly Ser Ser Phe Asn Trp Pro Tyr Met Ala Ile Gln 
                 405                410



<210> 6576
<211> 1563
<212> DNA
<213> Homo sapiens
<308> BC014664
<400> 6576

ccgagccac  cggggcgcc  tcccgcgcc  tcttgcacc  tcgcacaca  aaaaggcgg  540
gcgccggag  ccgagaccc  gggagtcgc  gccgccccg  cgccgcccg  agccagggg  600
gcaggaagt  cggacgcag  ccccataga  atggcaatg  tagtcagca  gtggcgcga  660
ccccaggac  aggtgcccg  ctcacaggg  agccaggcc  cgcaggcgc  gcccgtgcc  720
ggcccgccg  ccggcgccc  gcacacgcc  cagacgccc  gccaagggg  cccagccag  780
acgccagcc  agacggcgg  cggtggcca  ggcggccct  gcggcccgg  tagcgacaa  840
cagcagcag  agcaacaca  cgagtgcgt  gtgtgcgga  acaagtcga  cggcaagca  900
tacggccag  tcacgtgcg  gggctgcaa  agcttcttc  agcgcagcg  gcggaggaa  960
ctgagctac  cgtgccgcg  caaccggaa  tgtcccatc  accagcacc  tcgcaacca  1020
tgccagtac  gccgcctca  aaagtgcct  aaagtgggc  tgagacggg  agcggtgca  1080
aggggcagg  tgccgccga  ccagccgac  cacgggcag  tcgcgctga  caacgggga  1140
cccctcaac  gccactcgt  cctgtccgg  tatatttcc  tgctgttgc  cgcggagcc  1200
tatcccacg  cgcgcttcg  cagccaatg  atgcagccc  acaacatca  gggtatcga  1260
aacatttgc  aactggccg  gaggatgct  ttcagcgcc  tcgagtggg  ccggaacat  1320
cccttcttc  ccgacctgc  gatcacgga  caggtggcc  tgcttcgcc  cacctggag  1380
gagctgttt  tgttgaatg  ggcgcagtg  tccatgccc  tccacgtcg  cccgctcct  1440
gccgccgcc  gcctgcatg  ttcgcccat  tccgccgac  gggtggtcg  ctttatgga  1500
cacatacgg  tcttccaag  gcaagtgga  aagctcaag  cgctgcacg  tgactcagc  1560
gag  1563



<210> 6577
<211> 414
<212> PRT
<213> Homo sapiens
<308> P24468
<400> 6577

Met Ala Met Val Val Ser Thr Trp Arg Asp Pro Gln Asp Glu Val Pro 
  1               5                  10                  15
Gly Ser Gln Gly Ser Gln Ala Ser Gln Ala Pro Pro Val Pro Gly Pro 
             20                  25                  30
Pro Pro Gly Ala Pro His Thr Pro Gln Thr Pro Gly Gln Gly Gly Pro 
         35                  40                  45
Ala Ser Thr Pro Ala Gln Thr Ala Ala Gly Gly Gln Gly Gly Pro Gly 
     50                  55                  60
Gly Pro Gly Ser Asp Lys Gln Gln Gln Gln Gln His Ile Glu Cys Val 
 65                  70                  75                  80
Val Cys Gly Asp Lys Ser Ser Gly Lys His Tyr Gly Gln Phe Thr Cys 
                 85                  90                  95
Glu Gly Cys Lys Ser Phe Phe Lys Arg Ser Val Arg Arg Asn Leu Ser 
             100                105                110
Tyr Thr Cys Arg Ala Asn Arg Asn Cys Pro Ile Asp Gln His His Arg 
         115                120                125
Asn Gln Cys Gln Tyr Cys Arg Leu Lys Lys Cys Leu Lys Val Gly Met 
     130                135                140
Arg Arg Glu Ala Val Gln Arg Gly Arg Met Pro Pro Thr Gln Pro Thr 
 145                150                155                160
His Gly Gln Phe Ala Leu Thr Asn Gly Asp Pro Leu Asn Cys His Ser 
                 165                170                175
Tyr Leu Ser Gly Tyr Ile Ser Leu Leu Leu Arg Ala Glu Pro Tyr Pro 
             180                185                190
Thr Ser Arg Phe Gly Ser Gln Cys Met Gln Pro Asn Asn Ile Met Gly 
         195                200                205
Ile Glu Asn Ile Cys Glu Leu Ala Ala Arg Met Leu Phe Ser Ala Val 
     210                215                220
Glu Trp Ala Arg Asn Ile Pro Phe Phe Pro Asp Leu Gln Ile Thr Asp 
 225                230                235                240
Gln Val Ala Leu Leu Arg Leu Thr Trp Ser Glu Leu Phe Val Leu Asn 
                 245                250                255
Ala Ala Gln Cys Ser Met Pro Leu His Val Ala Pro Leu Leu Ala Ala 
             260                265                270
Ala Gly Leu His Ala Ser Pro Met Ser Ala Asp Arg Val Val Ala Phe 
         275                280                285
Met Asp His Ile Arg Ile Phe Gln Glu Gln Val Glu Lys Leu Lys Ala 
     290                295                300
Leu His Val Asp Ser Ala Glu Tyr Ser Cys Leu Lys Ala Ile Val Leu 
 305                310                315                320
Phe Thr Ser Asp Ala Cys Gly Leu Ser Asp Val Ala His Val Glu Ser 
                 325                330                335
Leu Gln Glu Lys Ser Gln Cys Ala Leu Glu Glu Tyr Val Arg Ser Gln 
             340                345                350
Tyr Pro Asn Gln Pro Thr Arg Phe Gly Lys Leu Leu Leu Arg Leu Pro 
         355                360                365
Ser Leu Arg Thr Val Ser Ser Ser Val Ile Glu Gln Leu Phe Phe Val 
     370                375                380
Arg Leu Val Gly Lys Thr Pro Ile Glu Thr Leu Ile Arg Asp Met Leu 
 385                390                395                400
Leu Ser Gly Ser Ser Phe Asn Trp Pro Tyr Met Ala Ile Gln 
                 405                410



<210> 6578
<211> 647
<212> DNA
<213> Rattus norvegicus
<308> AI012275
<400> 6578

caagtttac  ttttattaa  tacacagtt  acaagtttg  gttttctac  taggaaaag  60
ccagttaat  tcaggtgct  catagaaaa  ttagcattg  aaaaacaaa  acaaatcca  120
aattggcct  gtggctaat  gggaaaaaa  aactatttt  aaaggtagc  aaatctaac  180
aggtcggag  cctttataa  caaacagta  acttaccac  gaaattgca  tcaaactcc  240
ctatagcaa  actgtaacc  caaaatttg  ctacagcta  ttgtttcca  aaaaatctt  300
cttaaaaaa  taacagtta  gactataaa  atgtagttt  tctttacaa  gtaaaaaag  360
ttaaatctt  aataaatgg  aacaaaatg  tcctcttac  gtttttata  atagctctc  420
agacatata  tactcatct  ctgtaatct  tctttacct  agagaattt  ccaggatcc  480
aaaggatta  cttaaagac  tctatcatt  ccctcacat  aatgtggtt  agcttctgg  540
agtcaactg  atgaatgca  tctggctct  cccttgcgc  actaaaaca  aattaaatt  600
cctctttgg  aaaagccaa  tgttccggn  tttcgaaat  acttgtc  647



<210> 6579
<211> 1309
<212> DNA
<213> Homo sapiens
<308> AK026295
<400> 6579

tttattttt  tgtagagat  gggttgtcc  ggctggtct  aaactcctg  gctcaagca  60
tgtgcccgc  ttggcttcc  aaagtgctg  gattatagg  gtaaaccac  gcacgcagc  120
taccctctg  ctttttaag  tgatgtatt  atttaattt  tgccatcat  ggtgcttca  180
cttcctgcg  aggaaattc  agagcctgt  tttaagcta  ctaggcttt  acactccct  240
tattgcctt  ccaaatagt  tctcatttg  tgtactcta  tgtcctata  ctcttggaa  300
cgaaagagg  cccaaccta  aactaagaa  ggacaaacc  tgaactaag  aagacctta  360
acacccaga  agaacactg  gccctcctt  ttcagggac  atgcagtag  cacttggct  420
gtggaattt  ctgaaggct  tttcctgta  cttgctagt  aacttagtt  tgtatttca  480
gcagaggtg  gctctgtaa  gttgggcct  tgacttcac  gtactggag  gctgttcac  540
cagatgttt  gacctttct  tctctctct  ttttcttct  tctcaacaa  tctttcaca  600
aggcagtca  tttgaaagg  tgaaatatt  ggcctttac  aaagagctt  ttttttcct  660
aagcaaaat  ctttcagaa  gaaacaaat  gggaagggc  gattaagaa  gcatatgtc  720
caatccact  ctataggag  ttaatcata  tcacatgag  aaaatgatg  aagaactct  780
taaggtaat  ctttgggat  aaggatcct  ggaagttct  tcaggtaaa  aaagcttac  840
gcagatttg  aatatatgt  tggagagct  tttataaga  atttaagag  attgttttg  900
tttccttta  taaagattt  agccttttt  ctttgcaaa  agaaaacta  aaaagtttt  960
tagatataa  tttgctaat  ttttaaact  ttctgaaac  attagctgt  gccaaatta  1020
gtggttacg  tttgctaca  tagaatttg  aaatgcaat  tgtgtggta  atctactgt  1080
tgaaattta  aatggtctc  gatatgatt  gaattttgg  aacttttga  agttatttt  1140
cccctttag  catggattt  tatttgttt  ttaatgtta  tttttctag  aagcatctg  1200
attgactag  cttttccta  ataaaaaac  caaaacttg  taactctgt  ctttaataa  1260
atttaaaat  aaaactgtg  tgtttttta  aaaaaaaaa  aaaaaaaaa  1309



<210> 6580
<211> 631
<212> DNA
<213> Rattus norvegicus
<308> AI012589
<400> 6580

ctgccttac  aactttatt  gtctgggaa  agggggaca  ggagttcct  tcccttcgt  60
cactactgt  taccattgc  gttgatggg  cggttcaaa  ggtcagggg  ggacagaaa  120
gccttgatc  tggggcggg  actgaggcg  gccacatag  cagagagca  ggggaagtt  180
tccaggcag  caggggcca  gacttggtg  accagcagc  ggtccagca  gttgtaatc  240
gcaaaggaa  tctggttac  cacaatgaa  gctttgcct  cctggttct  ggacagcag  300
gtctcaaaa  gtttcagat  cccaggcag  gccttcaca  agtcatcct  accattctc  360
tagttagtg  agatgaggg  accatattt  catcgaagg  cctccaccc  atcattcac  420
atatccacc  aggcagcct  cttctggtc  ttcccataa  gccctaaag  gcgacccag  480
tgcctcaag  tggcattag  ttggtaaag  gtgaggtct  catcttcaa  cttggggag  540
tgcccatac  gacaagtgg  cttgagcga  ccttgaagc  agacatcta  ggtaaccac  600
tcctccttc  agctctggc  ctggtcagc  a  631



<210> 6581
<211> 209
<212> PRT
<213> Rattus norvegicus
<308> P04906
<400> 6581

Pro Pro Tyr Thr Ile Val Tyr Phe Pro Val Arg Gly Arg Cys Glu Ala 
  1               5                  10                  15
Thr Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu Val 
             20                  25                  30
Val Thr Ile Asp Val Trp Leu Gln Gly Ser Leu Lys Ser Thr Cys Leu 
         35                  40                  45
Tyr Gly Gln Leu Pro Lys Phe Glu Asp Gly Asp Leu Thr Leu Tyr Gln 
     50                  55                  60
Ser Asn Ala Ile Leu Arg His Leu Gly Arg Ser Leu Gly Leu Tyr Gly 
 65                  70                  75                  80
Lys Asp Gln Lys Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly Val 
                 85                  90                  95
Glu Asp Leu Arg Cys Lys Tyr Gly Thr Leu Ile Tyr Thr Asn Tyr Glu 
             100                105                110
Asn Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly His Leu Lys Pro 
         115                120                125
Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Ala Phe Ile Val 
     130                135                140
Gly Asn Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu Leu 
 145                150                155                160
Val His Gln Val Leu Ala Pro Gly Cys Leu Asp Asn Phe Pro Leu Leu 
                 165                170                175
Ser Ala Tyr Val Ala Arg Leu Ser Ala Arg Pro Lys Ile Lys Ala Phe 
             180                185                190
Leu Ser Ser Pro Asp His Leu Asn Arg Pro Ile Asn Gly Asn Gly Lys 
         195                200                205
Gln 
     210



<210> 6582
<211> 719
<212> DNA
<213> Homo sapiens
<308> U30897
<400> 6582

gtcttcgcc  ccatgccgc  ctacaccgt  gtctatttc  cagttcgag  ccgctgcgc  60
gccctgcgc  tgctgctgg  agatcaggg  cagagctgg  aggaggagg  ggtgaccgt  120
gagacgtgg  aggagggct  actcaaagc  tcctgccta  acgggcagc  ccccaagtt  180
caggacgga  acctcaccc  gtaccagtc  aataccatc  tgcgtcacc  gggccgcac  240
cttgggctc  atgggaagg  ccagcagga  gcagccctg  tggacatgg  gaatgacgg  300
gtggaggac  tccgctgca  atacgtctc  ctcatctac  ccaactatg  ggcgggcaa  360
gatgactat  tgaaggcac  gcccgggca  ctgaagcct  ttgagaccc  gctgtccca  420
aaccaggga  gcaagacct  cattgtggg  gaccagatc  ccttcgctg  ctacaacct  480
ctggacttg  tgctgatcc  tgaggtcct  gcccctggc  gcctggatg  gttccccct  540
ctctcagca  atgtggggc  cctcagtgc  cggcccaag  tcaaggcct  cctggcctc  600
cctgagtac  tgaacctcc  catcaatgg  aacgggaaa  agtgagggt  ggggggact  660
tgagcggga  gcagagttt  ccttccttt  tccaggacc  ataaaattt  taagagagc  719



<210> 6583
<211> 209
<212> PRT
<213> Homo sapiens
<308> P09211
<400> 6583

Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Gly Arg Cys Ala Ala 
  1               5                  10                  15
Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu Val 
             20                  25                  30
Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys Leu 
         35                  40                  45
Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr Gln 
     50                  55                  60
Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr Gly 
 65                  70                  75                  80
Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly Val 
                 85                  90                  95
Glu Asp Leu Arg Cys Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr Glu 
             100                105                110
Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys Pro 
         115                120                125
Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile Val 
     130                135                140
Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu Leu 
 145                150                155                160
Ile His Glu Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu Leu 
                 165                170                175
Ser Ala Tyr Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala Phe 
             180                185                190
Leu Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly Lys 
         195                200                205
Gln 
     210



<210> 6584
<211> 631
<212> DNA
<213> Rattus norvegicus
<308> AI012589
<400> 6584

ctgccttac  aactttatt  gtctgggaa  agggggaca  ggagttcct  tcccttcgt  60
cactactgt  taccattgc  gttgatggg  cggttcaaa  ggtcagggg  ggacagaaa  120
gccttgatc  tggggcggg  actgaggcg  gccacatag  cagagagca  ggggaagtt  180
tccaggcag  caggggcca  gacttggtg  accagcagc  ggtccagca  gttgtaatc  240
gcaaaggaa  tctggttac  cacaatgaa  gctttgcct  cctggttct  ggacagcag  300
gtctcaaaa  gtttcagat  cccaggcag  gccttcaca  agtcatcct  accattctc  360
tagttagtg  agatgaggg  accatattt  catcgaagg  cctccaccc  atcattcac  420
atatccacc  aggcagcct  cttctggtc  ttcccataa  gccctaaag  gcgacccag  480
tgcctcaag  tggcattag  ttggtaaag  gtgaggtct  catcttcaa  cttggggag  540
tgcccatac  gacaagtgg  cttgagcga  ccttgaagc  agacatcta  ggtaaccac  600
tcctccttc  agctctggc  ctggtcagc  a  631



<210> 6585
<211> 209
<212> PRT
<213> Rattus norvegicus
<308> P04906
<400> 6585

Pro Pro Tyr Thr Ile Val Tyr Phe Pro Val Arg Gly Arg Cys Glu Ala 
  1               5                  10                  15
Thr Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu Val 
             20                  25                  30
Val Thr Ile Asp Val Trp Leu Gln Gly Ser Leu Lys Ser Thr Cys Leu 
         35                  40                  45
Tyr Gly Gln Leu Pro Lys Phe Glu Asp Gly Asp Leu Thr Leu Tyr Gln 
     50                  55                  60
Ser Asn Ala Ile Leu Arg His Leu Gly Arg Ser Leu Gly Leu Tyr Gly 
 65                  70                  75                  80
Lys Asp Gln Lys Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly Val 
                 85                  90                  95
Glu Asp Leu Arg Cys Lys Tyr Gly Thr Leu Ile Tyr Thr Asn Tyr Glu 
             100                105                110
Asn Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly His Leu Lys Pro 
         115                120                125
Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Ala Phe Ile Val 
     130                135                140
Gly Asn Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu Leu 
 145                150                155                160
Val His Gln Val Leu Ala Pro Gly Cys Leu Asp Asn Phe Pro Leu Leu 
                 165                170                175
Ser Ala Tyr Val Ala Arg Leu Ser Ala Arg Pro Lys Ile Lys Ala Phe 
             180                185                190
Leu Ser Ser Pro Asp His Leu Asn Arg Pro Ile Asn Gly Asn Gly Lys 
         195                200                205
Gln 
     210



<210> 6586
<211> 719
<212> DNA
<213> Homo sapiens
<308> U30897
<400> 6586

gtcttcgcc  ccatgccgc  ctacaccgt  gtctatttc  cagttcgag  ccgctgcgc  60
gccctgcgc  tgctgctgg  agatcaggg  cagagctgg  aggaggagg  ggtgaccgt  120
gagacgtgg  aggagggct  actcaaagc  tcctgccta  acgggcagc  ccccaagtt  180
caggacgga  acctcaccc  gtaccagtc  aataccatc  tgcgtcacc  gggccgcac  240
cttgggctc  atgggaagg  ccagcagga  gcagccctg  tggacatgg  gaatgacgg  300
gtggaggac  tccgctgca  atacgtctc  ctcatctac  ccaactatg  ggcgggcaa  360
gatgactat  tgaaggcac  gcccgggca  ctgaagcct  ttgagaccc  gctgtccca  420
aaccaggga  gcaagacct  cattgtggg  gaccagatc  ccttcgctg  ctacaacct  480
ctggacttg  tgctgatcc  tgaggtcct  gcccctggc  gcctggatg  gttccccct  540
ctctcagca  atgtggggc  cctcagtgc  cggcccaag  tcaaggcct  cctggcctc  600
cctgagtac  tgaacctcc  catcaatgg  aacgggaaa  agtgagggt  ggggggact  660
tgagcggga  gcagagttt  ccttccttt  tccaggacc  ataaaattt  taagagagc  719



<210> 6587
<211> 209
<212> PRT
<213> Homo sapiens
<308> P09211
<400> 6587

Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Gly Arg Cys Ala Ala 
  1               5                  10                  15
Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu Val 
             20                  25                  30
Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys Leu 
         35                  40                  45
Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr Gln 
     50                  55                  60
Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr Gly 
 65                  70                  75                  80
Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly Val 
                 85                  90                  95
Glu Asp Leu Arg Cys Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr Glu 
             100                105                110
Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys Pro 
         115                120                125
Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile Val 
     130                135                140
Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu Leu 
 145                150                155                160
Ile His Glu Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu Leu 
                 165                170                175
Ser Ala Tyr Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala Phe 
             180                185                190
Leu Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly Lys 
         195                200                205
Gln 
     210



<210> 6588
<211> 614
<212> DNA
<213> Rattus norvegicus
<308> AI012604
<400> 6588

cttgcggcc  cgagatttt  cttttattt  ttttttttt  ttttttttt  ttttttttt  60
tttaatttt  taacattgt  ttaatcaag  aatgtagct  tttgaaaca  gaaactttt  120
aagacacct  aatagagcc  tgaaggatt  ctcttacca  gttaacctc  atgaataaa  180
acccagatt  tgtgaaatt  gaatcccac  ggtttggca  cagaatgaa  agaagccca  240
gaccttcct  agtgtctaa  acctgacca  ttcccttta  agcaacagc  ctaagacaa  300
atcttgcca  cctgaggcc  aaatgtgct  atctacttg  gaatctcaa  aagtaatga  360
atatggatg  gctgcccat  caacaaaga  tctgaaacc  aggagacaa  tgactttcc  420
agtcccact  ctttggtgt  acacagcac  ttcccctgt  accattcca  gtatatggc  480
cctgttcca  gcccagcct  ctatcaagg  tttaatttt  ccaaatgtt  ggtatgatt  540
taacgcata  tttttacat  aatcaaagt  ttataatct  tgagatgga  gacacaaag  600
ataagatcc  aata  614



<210> 6589
<211> 429
<212> PRT
<213> Rattus norvegicus
<308> Q07205
<400> 6589

Met Ser Val Asn Val Asn Arg Ser Val Ser Asp Gln Phe Tyr Arg Tyr 
  1               5                  10                  15
Lys Met Pro Arg Leu Ile Ala Lys Val Glu Gly Lys Gly Asn Gly Ile 
             20                  25                  30
Lys Thr Val Ile Val Asn Met Val Asp Val Ala Lys Ala Leu Asn Arg 
         35                  40                  45
Pro Pro Thr Tyr Pro Thr Lys Tyr Phe Gly Cys Glu Leu Gly Ala Gln 
     50                  55                  60
Thr Gln Phe Asp Val Lys Asn Asp Arg Tyr Ile Val Asn Gly Ser His 
 65                  70                  75                  80
Glu Ala Asn Lys Leu Gln Asp Met Leu Asp Gly Phe Ile Lys Lys Phe 
                 85                  90                  95
Val Leu Cys Pro Glu Cys Glu Asn Pro Glu Thr Asp Leu His Val Asn 
             100                105                110
Pro Lys Lys Gln Thr Ile Gly Asn Ser Cys Lys Ala Cys Gly Tyr Arg 
         115                120                125
Gly Met Leu Asp Thr His His Lys Leu Cys Thr Phe Ile Leu Lys Asn 
     130                135                140
Pro Pro Glu Asn Ser Asp Ile Gly Thr Gly Lys Lys Glu Lys Glu Lys 
 145                150                155                160
Lys Asn Arg Lys Gly Lys Asp Lys Glu Asn Gly Ser Val Ser Thr Ser 
                 165                170                175
Glu Thr Pro Pro Pro Pro Pro Pro Asn Glu Ile Ser Pro Pro His Ala 
             180                185                190
Val Glu Glu Glu Glu Asp Asp Asp Trp Gly Glu Asp Thr Thr Glu Glu 
         195                200                205
Ala Gln Arg Arg Arg Met Asp Glu Ile Ser Asp His Ala Lys Gly Leu 
     210                215                220
Thr Leu Ser Asp Asp Leu Glu Arg Thr Val Glu Glu Arg Val Asn Ile 
 225                230                235                240
Leu Phe Asp Phe Val Lys Lys Lys Lys Glu Glu Gly Ile Ile Asp Ser 
                 245                250                255
Ser Asp Lys Asp Ile Val Ala Glu Ala Glu Arg Leu Asp Val Lys Ala 
             260                265                270
Met Gly Pro Leu Val Leu Thr Glu Val Leu Phe Asp Glu Lys Ile Arg 
         275                280                285
Glu Gln Ile Lys Lys Tyr Arg Arg His Phe Leu Arg Phe Cys His Asn 
     290                295                300
Asn Lys Lys Ala Gln Arg Tyr Leu Leu His Gly Leu Glu Cys Val Val 
 305                310                315                320
Ala Met His Gln Ala Gln Leu Ile Ser Lys Ile Pro His Ile Leu Lys 
                 325                330                335
Glu Met Tyr Asp Ala Asp Leu Leu Glu Glu Glu Val Ile Ile Ser Trp 
             340                345                350
Ser Glu Lys Ala Ser Lys Lys Tyr Val Ser Lys Glu Leu Ala Lys Glu 
         355                360                365
Ile Arg Val Lys Ala Glu Pro Phe Ile Lys Trp Leu Lys Glu Ala Glu 
     370                375                380
Glu Glu Ser Ser Gly Gly Glu Glu Glu Asp Glu Asp Glu Asn Ile Glu 
 385                390                395                400
Val Val Tyr Ser Lys Thr Ala Ser Val Pro Lys Val Glu Thr Val Lys 
                 405                410                415
Ser Asp Asn Lys Asp Asp Asp Ile Asp Ile Asp Ala Ile 
             420                425



<210> 6590
<211> 3899
<212> DNA
<213> Homo sapiens
<308> NM_001969
<400> 6590

agcttgagc  cggcggcgg  gttgttcag  cagagcgag  acattccag  ggtcgccca  60
ctccggcgc  gacgggtgt  gaccgcgga  gtcgctggg  cagcccctc  ccgctgctc  120
gcggcggca  ctggcccgg  cgctcctcg  tgcgcttcg  ctccgcctc  tcggactcg  180
actcgggtt  atatcgcgc  tcacttcat  ccagtcccg  gcgagcagc  ttgggttta  240
gtctttatt  gacgaaaac  agctgttgc  cagccattg  tacctgtat  ggggaaaca  300
agcatacaa  caagaagct  acagcctca  tggcgaaaa  tttttcatg  cagagaccg  360
gaactcttg  agtcgttta  gtcatccct  cttctccag  cagaagata  caaaaagtt  420
caatcaaag  tctcttcat  ttattgata  agccactaa  aagccaaaa  gtctgtcaa  480
gtcaaccgc  gcgtgtcag  ccagttcta  cgctacaag  tgccccgtc  gattgccaa  540
gttgagggc  aaggcaatg  aatcaagac  gttatagtc  acatggttg  cgttgcaaa  600
gcgcttaat  ggcctccaa  gtatcccac  aaatatttt  gttgtgagc  gggagcaca  660
acccagttt  atgttaaga  tgaccgtta  attgtcaat  gatctcatg  ggcgaataa  720
ctgcaagac  tgttggatg  attcattaa  aaatttgtt  tctgtcctg  atgtgagaa  780
cctgaaaca  atttgcatg  caatccaaa  aagcaaaca  taggtaatt  ttgtaaagc  840
tgtggctat  gaggcatgc  tgacacaca  cataaactc  gcacattca  tctcaaaaa  900
ccacctgag  atagtgaca  tggtacagg  aagaaagaa  aagaaaaga  aaacagaaa  960
ggcaaagac  aggaaaatg  ctccgtatc  agcagtgag  caccaccac  accaccacc  1020
ccaaatgaa  ttaatcctc  tccacatac  atggaagaa  aggaggatg  tgactgggg  1080
gaagataca  ctgaggaag  tcaaaggcg  cgaatggat  aaatcagtg  ccatgcaaa  1140
gttctgaca  tcagtgatg  tttggaaag  acaattgag  agagggtca  tatcctctt  1200
gattttgtt  agaaaaaga  agaagaggg  gttattgat  catctgaca  agaaatcgt  1260
gctgaagca  aaagactgg  tgtaaaagc  atgggccct  ttgttctaa  tgaagttct  1320
tttaatgag  agattagag  acagattaa  aaatacagg  gccatttcc  acgattttg  1380
cacaacaac  aaaaagccc  acggtacct  cttcatggt  tggagtgtg  ggtagcaat  1440
catcaagct  agcttatct  caagattcc  catatcttg  aggagatgt  cgatgcaga  1500
cttttagaa  aagaggtca  catcagctg  tcggaaaag  cctctaaga  atatgtctc  1560
aaagaactt  ccaaagaga  tcgtgtcaa  gcagaacca  ttataaaat  gttgaagga  1620
gcagaggaa  aatcttctg  tggcgaaga  gaagatgaa  atgagaaca  tgaggtggt  1680
tattcgaag  ctgccagtg  accgaaagt  gagactgta  agtcagaca  caaggatga  1740
gacatcgat  ttgatgcca  ttaaaggga  ggatgcaac  tagcttaac  gtataatgc  1800
gcaaatttt  ctccattat  agccagaag  gcaacatgt  tgtgcaaaa  ctaaaatgg  1860
ttaacatca  gctacactt  acactaaaa  tctattact  tgagtggtc  gttattaag  1920
ccaatgaga  atctaggga  tccatacac  tcagtgagc  gatgtagtt  gcttattta  1980
agcatgttt  tttttgaaa  actagtggt  gacacattt  gatcacatt  atacagtta  2040
aaaaataaa  gtttgattt  ggtcgttct  cagatgttt  gctctgaat  acttaagct  2100
aagtaactg  ctccttact  taaatgttc  gccatcatt  cacctgatg  gcattcttg  2160
agcctgcca  atattgtta  gtcctgggg  tgcaaagag  tcctcaaca  gatgtaaag  2220
aaacttaat  gtaattaat  tattcagcc  attaagaaa  tactaaagt  ttatctctg  2280
agttcctca  attggcatc  ggtaatgta  attgtgagg  agactgata  tgaaatgac  2340
gtgcaacat  ttaaccaag  agtaaatat  acctcagtg  cctataaat  atgtaagag  2400
aggatttga  acttggaga  ctgttttct  atttcatgt  cacttgccc  aaattgtct  2460
tgaagtcgt  tgcattgca  gttggatga  ccagggaaa  tattacatt  acaagcatt  2520
tgtgtgtgc  tagtagtta  tttgtactg  gagaacttg  tttggggtg  aattaaaca  2580
taaactgat  ttatttggg  gaaacaagg  agggtgcac  taactagca  cctaagcat  2640
atttttcag  ttttgccct  agggtttaa  ttacaattc  aaaatgtta  acatactgt  2700
ttttttcgt  cagtgtggc  ttaattttc  cctcttgca  tttgttctg  aatgccttt  2760
acatttgga  acatagttt  tgcttttta  attttggtt  ctttcttgc  aaaataagt  2820
ttaactgtg  ttcaaactt  attttcttt  ttttttctt  ttttttctt  cagaatgtc  2880
tatttaaaa  gaaagctaa  agcatactt  taagtcaga  cctctattt  ggtgtaaga  2940
ttgggatat  ttttacttc  cattgaata  agccaggca  ccaagaagt  tgatggcca  3000
ctgagtgca  gtgacaagg  cctgacaga  cccatgcag  gctttagat  tggacacac  3060
agagttgat  acttcctca  gaactcctt  cctgatcta  actcatatt  tgggttctg  3120
ctgtttgag  aatcgtctt  aaggttaaa  ctcttggca  ttacccttt  cacaaagtg  3180
acagtggga  tcgagaatc  atagggtta  ttttggagc  gtggcttat  ccattcacc  3240
ctgtttttt  gtgattatt  cacagataa  gagacctta  taacaaata  gcgtaaaaa  3300
attttcaca  tgaaatgat  gaaacattt  atgtaataa  acttggttg  cttgatatt  3360
taaggaatt  aaacctagc  atcttattg  agagacaag  attggtctc  agctgcctt  3420
gatcaagat  cgggtgcaa  tggagcagg  gccatatac  tggagggaa  gtgctttgt  3480
acaccaaag  ggatttttt  tttcttcaa  cttgtatgt  gcctaggtt  caaattctt  3540
gccgcaagg  tgatctgct  tcattaact  gaattctgt  ggagatact  gtgacctaa  3600
ctaagttgc  ctcagcata  tcagtgtca  gctaatgag  ttctattat  aaggttcta  3660
ttttaatct  agggaaaac  tgttcaggg  ttctagaac  ctaaaaaat  tggcttaaa  3720
cagtgttca  tctggtgcc  aacttcgaa  ggaatacaa  ttcacataa  ctgaacttt  3780
ttcacaggt  atcctaata  agtaattct  cactttgct  tattgaact  tcttaagga  3840
ttgtttaaa  agctaagtt  cttgattaa  ataatgata  aattgtaaa  aaaaaaaaa  3899



<210> 6591
<211> 431
<212> PRT
<213> Homo sapiens
<308> P55010
<400> 6591

Met Ser Val Asn Val Asn Arg Ser Val Ser Asp Gln Phe Tyr Arg Tyr 
  1               5                  10                  15
Lys Met Pro Arg Leu Ile Ala Lys Val Glu Gly Lys Gly Asn Gly Ile 
             20                  25                  30
Lys Thr Val Ile Val Asn Met Val Asp Val Ala Lys Ala Leu Asn Arg 
         35                  40                  45
Pro Pro Thr Tyr Pro Thr Lys Tyr Phe Gly Cys Glu Leu Gly Ala Gln 
     50                  55                  60
Thr Gln Phe Asp Val Lys Asn Asp Arg Tyr Ile Val Asn Gly Ser His 
 65                  70                  75                  80
Glu Ala Asn Lys Leu Gln Asp Met Leu Asp Gly Phe Ile Lys Lys Phe 
                 85                  90                  95
Val Leu Cys Pro Glu Cys Glu Asn Pro Glu Thr Asp Leu His Val Asn 
             100                105                110
Pro Lys Lys Gln Thr Ile Gly Asn Ser Cys Lys Ala Cys Gly Tyr Arg 
         115                120                125
Gly Met Leu Asp Thr His His Lys Leu Cys Thr Phe Ile Leu Lys Asn 
     130                135                140
Pro Pro Glu Asn Ser Asp Ser Gly Thr Gly Lys Lys Glu Lys Glu Lys 
 145                150                155                160
Lys Asn Arg Lys Gly Lys Asp Lys Glu Asn Gly Ser Val Ser Ser Ser 
                 165                170                175
Glu Thr Pro Pro Pro Pro Pro Pro Pro Asn Glu Ile Asn Pro Pro Pro 
             180                185                190
His Thr Met Glu Glu Glu Glu Asp Asp Asp Ser Gly Glu Asp Thr Thr 
         195                200                205
Glu Glu Ala Gln Arg Arg Arg Met Asp Glu Ile Ser Asp His Ala Lys 
     210                215                220
Val Leu Thr Leu Ser Asp Asp Leu Glu Arg Thr Ile Glu Glu Arg Val 
 225                230                235                240
Asn Ile Leu Phe Asp Phe Val Lys Lys Lys Lys Glu Glu Gly Val Ile 
                 245                250                255
Asp Ser Ser Asp Lys Glu Ile Val Ala Glu Ala Glu Arg Leu Asp Val 
             260                265                270
Lys Ala Met Gly Pro Leu Val Leu Thr Glu Val Leu Phe Asn Glu Lys 
         275                280                285
Ile Arg Glu Gln Ile Lys Lys Tyr Arg Arg His Phe Leu Arg Phe Cys 
     290                295                300
His Asn Asn Lys Lys Ala Gln Arg Tyr Leu Leu His Gly Leu Glu Cys 
 305                310                315                320
Val Val Ala Met His Gln Ala Gln Leu Ile Ser Lys Ile Pro His Ile 
                 325                330                335
Leu Lys Glu Met Tyr Asp Ala Asp Leu Leu Glu Glu Glu Val Ile Ile 
             340                345                350
Ser Trp Ser Glu Lys Ala Ser Lys Lys Tyr Val Ser Lys Glu Leu Ala 
         355                360                365
Lys Glu Ile Arg Val Lys Ala Glu Pro Phe Ile Lys Trp Leu Lys Glu 
     370                375                380
Ala Glu Glu Glu Ser Ser Gly Gly Glu Glu Glu Asp Glu Asp Glu Asn 
 385                390                395                400
Ile Glu Val Val Tyr Ser Lys Ala Ala Ser Val Pro Lys Val Glu Thr 
                 405                410                415
Val Lys Ser Asp Asn Lys Asp Asp Asp Ile Asp Ile Asp Ala Ile 
             420                425                430



<210> 6592
<211> 464
<212> DNA
<213> Rattus norvegicus
<308> AI013194
<400> 6592

cctgtacca  tgtcactat  ctcaggtgg  tttttgaga  tgaatgtac  gagtttatg  60
tgtgtgtca  gcatgcctc  gtacccaca  gctttacaa  aattaccta  tgtttgctt  120
tttggattg  catgcagat  tgtttcagg  ttctcacac  caggacaga  aacaaattt  180
ttaatgaat  catccaaca  gtcttgcag  ttattcgcc  catgagatc  attgacaat  240
taacggtca  tcttaacat  aaactgggt  tgtgctccc  gctcacaac  aaaatattt  300
gtgggatac  ttggaggcc  attaagcgc  tttgcaacg  caaccatgt  gactataac  360
gtcttgatt  catttcctt  gccctcaac  ttagcaatc  aacggggca  cttgtagcg  420
tagaactgg  ctgacacgc  gcggttgac  ttgacagac  tttt  464



<210> 6593
<211> 429
<212> PRT
<213> Rattus norvegicus
<308> Q07205
<400> 6593

Met Ser Val Asn Val Asn Arg Ser Val Ser Asp Gln Phe Tyr Arg Tyr 
  1               5                  10                  15
Lys Met Pro Arg Leu Ile Ala Lys Val Glu Gly Lys Gly Asn Gly Ile 
             20                  25                  30
Lys Thr Val Ile Val Asn Met Val Asp Val Ala Lys Ala Leu Asn Arg 
         35                  40                  45
Pro Pro Thr Tyr Pro Thr Lys Tyr Phe Gly Cys Glu Leu Gly Ala Gln 
     50                  55                  60
Thr Gln Phe Asp Val Lys Asn Asp Arg Tyr Ile Val Asn Gly Ser His 
 65                  70                  75                  80
Glu Ala Asn Lys Leu Gln Asp Met Leu Asp Gly Phe Ile Lys Lys Phe 
                 85                  90                  95
Val Leu Cys Pro Glu Cys Glu Asn Pro Glu Thr Asp Leu His Val Asn 
             100                105                110
Pro Lys Lys Gln Thr Ile Gly Asn Ser Cys Lys Ala Cys Gly Tyr Arg 
         115                120                125
Gly Met Leu Asp Thr His His Lys Leu Cys Thr Phe Ile Leu Lys Asn 
     130                135                140
Pro Pro Glu Asn Ser Asp Ile Gly Thr Gly Lys Lys Glu Lys Glu Lys 
 145                150                155                160
Lys Asn Arg Lys Gly Lys Asp Lys Glu Asn Gly Ser Val Ser Thr Ser 
                 165                170                175
Glu Thr Pro Pro Pro Pro Pro Pro Asn Glu Ile Ser Pro Pro His Ala 
             180                185                190
Val Glu Glu Glu Glu Asp Asp Asp Trp Gly Glu Asp Thr Thr Glu Glu 
         195                200                205
Ala Gln Arg Arg Arg Met Asp Glu Ile Ser Asp His Ala Lys Gly Leu 
     210                215                220
Thr Leu Ser Asp Asp Leu Glu Arg Thr Val Glu Glu Arg Val Asn Ile 
 225                230                235                240
Leu Phe Asp Phe Val Lys Lys Lys Lys Glu Glu Gly Ile Ile Asp Ser 
                 245                250                255
Ser Asp Lys Asp Ile Val Ala Glu Ala Glu Arg Leu Asp Val Lys Ala 
             260                265                270
Met Gly Pro Leu Val Leu Thr Glu Val Leu Phe Asp Glu Lys Ile Arg 
         275                280                285
Glu Gln Ile Lys Lys Tyr Arg Arg His Phe Leu Arg Phe Cys His Asn 
     290                295                300
Asn Lys Lys Ala Gln Arg Tyr Leu Leu His Gly Leu Glu Cys Val Val 
 305                310                315                320
Ala Met His Gln Ala Gln Leu Ile Ser Lys Ile Pro His Ile Leu Lys 
                 325                330                335
Glu Met Tyr Asp Ala Asp Leu Leu Glu Glu Glu Val Ile Ile Ser Trp 
             340                345                350
Ser Glu Lys Ala Ser Lys Lys Tyr Val Ser Lys Glu Leu Ala Lys Glu 
         355                360                365
Ile Arg Val Lys Ala Glu Pro Phe Ile Lys Trp Leu Lys Glu Ala Glu 
     370                375                380
Glu Glu Ser Ser Gly Gly Glu Glu Glu Asp Glu Asp Glu Asn Ile Glu 
 385                390                395                400
Val Val Tyr Ser Lys Thr Ala Ser Val Pro Lys Val Glu Thr Val Lys 
                 405                410                415
Ser Asp Asn Lys Asp Asp Asp Ile Asp Ile Asp Ala Ile 
             420                425



<210> 6594
<211> 3899
<212> DNA
<213> Homo sapiens
<308> NM_001969
<400> 6594

agcttgagc  cggcggcgg  gttgttcag  cagagcgag  acattccag  ggtcgccca  60
ctccggcgc  gacgggtgt  gaccgcgga  gtcgctggg  cagcccctc  ccgctgctc  120
gcggcggca  ctggcccgg  cgctcctcg  tgcgcttcg  ctccgcctc  tcggactcg  180
actcgggtt  atatcgcgc  tcacttcat  ccagtcccg  gcgagcagc  ttgggttta  240
gtctttatt  gacgaaaac  agctgttgc  cagccattg  tacctgtat  ggggaaaca  300
agcatacaa  caagaagct  acagcctca  tggcgaaaa  tttttcatg  cagagaccg  360
gaactcttg  agtcgttta  gtcatccct  cttctccag  cagaagata  caaaaagtt  420
caatcaaag  tctcttcat  ttattgata  agccactaa  aagccaaaa  gtctgtcaa  480
gtcaaccgc  gcgtgtcag  ccagttcta  cgctacaag  tgccccgtc  gattgccaa  540
gttgagggc  aaggcaatg  aatcaagac  gttatagtc  acatggttg  cgttgcaaa  600
gcgcttaat  ggcctccaa  gtatcccac  aaatatttt  gttgtgagc  gggagcaca  660
acccagttt  atgttaaga  tgaccgtta  attgtcaat  gatctcatg  ggcgaataa  720
ctgcaagac  tgttggatg  attcattaa  aaatttgtt  tctgtcctg  atgtgagaa  780
cctgaaaca  atttgcatg  caatccaaa  aagcaaaca  taggtaatt  ttgtaaagc  840
tgtggctat  gaggcatgc  tgacacaca  cataaactc  gcacattca  tctcaaaaa  900
ccacctgag  atagtgaca  tggtacagg  aagaaagaa  aagaaaaga  aaacagaaa  960
ggcaaagac  aggaaaatg  ctccgtatc  agcagtgag  caccaccac  accaccacc  1020
ccaaatgaa  ttaatcctc  tccacatac  atggaagaa  aggaggatg  tgactgggg  1080
gaagataca  ctgaggaag  tcaaaggcg  cgaatggat  aaatcagtg  ccatgcaaa  1140
gttctgaca  tcagtgatg  tttggaaag  acaattgag  agagggtca  tatcctctt  1200
gattttgtt  agaaaaaga  agaagaggg  gttattgat  catctgaca  agaaatcgt  1260
gctgaagca  aaagactgg  tgtaaaagc  atgggccct  ttgttctaa  tgaagttct  1320
tttaatgag  agattagag  acagattaa  aaatacagg  gccatttcc  acgattttg  1380
cacaacaac  aaaaagccc  acggtacct  cttcatggt  tggagtgtg  ggtagcaat  1440
catcaagct  agcttatct  caagattcc  catatcttg  aggagatgt  cgatgcaga  1500
cttttagaa  aagaggtca  catcagctg  tcggaaaag  cctctaaga  atatgtctc  1560
aaagaactt  ccaaagaga  tcgtgtcaa  gcagaacca  ttataaaat  gttgaagga  1620
gcagaggaa  aatcttctg  tggcgaaga  gaagatgaa  atgagaaca  tgaggtggt  1680
tattcgaag  ctgccagtg  accgaaagt  gagactgta  agtcagaca  caaggatga  1740
gacatcgat  ttgatgcca  ttaaaggga  ggatgcaac  tagcttaac  gtataatgc  1800
gcaaatttt  ctccattat  agccagaag  gcaacatgt  tgtgcaaaa  ctaaaatgg  1860
ttaacatca  gctacactt  acactaaaa  tctattact  tgagtggtc  gttattaag  1920
ccaatgaga  atctaggga  tccatacac  tcagtgagc  gatgtagtt  gcttattta  1980
agcatgttt  tttttgaaa  actagtggt  gacacattt  gatcacatt  atacagtta  2040
aaaaataaa  gtttgattt  ggtcgttct  cagatgttt  gctctgaat  acttaagct  2100
aagtaactg  ctccttact  taaatgttc  gccatcatt  cacctgatg  gcattcttg  2160
agcctgcca  atattgtta  gtcctgggg  tgcaaagag  tcctcaaca  gatgtaaag  2220
aaacttaat  gtaattaat  tattcagcc  attaagaaa  tactaaagt  ttatctctg  2280
agttcctca  attggcatc  ggtaatgta  attgtgagg  agactgata  tgaaatgac  2340
gtgcaacat  ttaaccaag  agtaaatat  acctcagtg  cctataaat  atgtaagag  2400
aggatttga  acttggaga  ctgttttct  atttcatgt  cacttgccc  aaattgtct  2460
tgaagtcgt  tgcattgca  gttggatga  ccagggaaa  tattacatt  acaagcatt  2520
tgtgtgtgc  tagtagtta  tttgtactg  gagaacttg  tttggggtg  aattaaaca  2580
taaactgat  ttatttggg  gaaacaagg  agggtgcac  taactagca  cctaagcat  2640
atttttcag  ttttgccct  agggtttaa  ttacaattc  aaaatgtta  acatactgt  2700
ttttttcgt  cagtgtggc  ttaattttc  cctcttgca  tttgttctg  aatgccttt  2760
acatttgga  acatagttt  tgcttttta  attttggtt  ctttcttgc  aaaataagt  2820
ttaactgtg  ttcaaactt  attttcttt  ttttttctt  ttttttctt  cagaatgtc  2880
tatttaaaa  gaaagctaa  agcatactt  taagtcaga  cctctattt  ggtgtaaga  2940
ttgggatat  ttttacttc  cattgaata  agccaggca  ccaagaagt  tgatggcca  3000
ctgagtgca  gtgacaagg  cctgacaga  cccatgcag  gctttagat  tggacacac  3060
agagttgat  acttcctca  gaactcctt  cctgatcta  actcatatt  tgggttctg  3120
ctgtttgag  aatcgtctt  aaggttaaa  ctcttggca  ttacccttt  cacaaagtg  3180
acagtggga  tcgagaatc  atagggtta  ttttggagc  gtggcttat  ccattcacc  3240
ctgtttttt  gtgattatt  cacagataa  gagacctta  taacaaata  gcgtaaaaa  3300
attttcaca  tgaaatgat  gaaacattt  atgtaataa  acttggttg  cttgatatt  3360
taaggaatt  aaacctagc  atcttattg  agagacaag  attggtctc  agctgcctt  3420
gatcaagat  cgggtgcaa  tggagcagg  gccatatac  tggagggaa  gtgctttgt  3480
acaccaaag  ggatttttt  tttcttcaa  cttgtatgt  gcctaggtt  caaattctt  3540
gccgcaagg  tgatctgct  tcattaact  gaattctgt  ggagatact  gtgacctaa  3600
ctaagttgc  ctcagcata  tcagtgtca  gctaatgag  ttctattat  aaggttcta  3660
ttttaatct  agggaaaac  tgttcaggg  ttctagaac  ctaaaaaat  tggcttaaa  3720
cagtgttca  tctggtgcc  aacttcgaa  ggaatacaa  ttcacataa  ctgaacttt  3780
ttcacaggt  atcctaata  agtaattct  cactttgct  tattgaact  tcttaagga  3840
ttgtttaaa  agctaagtt  cttgattaa  ataatgata  aattgtaaa  aaaaaaaaa  3899



<210> 6595
<211> 431
<212> PRT
<213> Homo sapiens
<308> P55010
<400> 6595

Met Ser Val Asn Val Asn Arg Ser Val Ser Asp Gln Phe Tyr Arg Tyr 
  1               5                  10                  15
Lys Met Pro Arg Leu Ile Ala Lys Val Glu Gly Lys Gly Asn Gly Ile 
             20                  25                  30
Lys Thr Val Ile Val Asn Met Val Asp Val Ala Lys Ala Leu Asn Arg 
         35                  40                  45
Pro Pro Thr Tyr Pro Thr Lys Tyr Phe Gly Cys Glu Leu Gly Ala Gln 
     50                  55                  60
Thr Gln Phe Asp Val Lys Asn Asp Arg Tyr Ile Val Asn Gly Ser His 
 65                  70                  75                  80
Glu Ala Asn Lys Leu Gln Asp Met Leu Asp Gly Phe Ile Lys Lys Phe 
                 85                  90                  95
Val Leu Cys Pro Glu Cys Glu Asn Pro Glu Thr Asp Leu His Val Asn 
             100                105                110
Pro Lys Lys Gln Thr Ile Gly Asn Ser Cys Lys Ala Cys Gly Tyr Arg 
         115                120                125
Gly Met Leu Asp Thr His His Lys Leu Cys Thr Phe Ile Leu Lys Asn 
     130                135                140
Pro Pro Glu Asn Ser Asp Ser Gly Thr Gly Lys Lys Glu Lys Glu Lys 
 145                150                155                160
Lys Asn Arg Lys Gly Lys Asp Lys Glu Asn Gly Ser Val Ser Ser Ser 
                 165                170                175
Glu Thr Pro Pro Pro Pro Pro Pro Pro Asn Glu Ile Asn Pro Pro Pro 
             180                185                190
His Thr Met Glu Glu Glu Glu Asp Asp Asp Ser Gly Glu Asp Thr Thr 
         195                200                205
Glu Glu Ala Gln Arg Arg Arg Met Asp Glu Ile Ser Asp His Ala Lys 
     210                215                220
Val Leu Thr Leu Ser Asp Asp Leu Glu Arg Thr Ile Glu Glu Arg Val 
 225                230                235                240
Asn Ile Leu Phe Asp Phe Val Lys Lys Lys Lys Glu Glu Gly Val Ile 
                 245                250                255
Asp Ser Ser Asp Lys Glu Ile Val Ala Glu Ala Glu Arg Leu Asp Val 
             260                265                270
Lys Ala Met Gly Pro Leu Val Leu Thr Glu Val Leu Phe Asn Glu Lys 
         275                280                285
Ile Arg Glu Gln Ile Lys Lys Tyr Arg Arg His Phe Leu Arg Phe Cys 
     290                295                300
His Asn Asn Lys Lys Ala Gln Arg Tyr Leu Leu His Gly Leu Glu Cys 
 305                310                315                320
Val Val Ala Met His Gln Ala Gln Leu Ile Ser Lys Ile Pro His Ile 
                 325                330                335
Leu Lys Glu Met Tyr Asp Ala Asp Leu Leu Glu Glu Glu Val Ile Ile 
             340                345                350
Ser Trp Ser Glu Lys Ala Ser Lys Lys Tyr Val Ser Lys Glu Leu Ala 
         355                360                365
Lys Glu Ile Arg Val Lys Ala Glu Pro Phe Ile Lys Trp Leu Lys Glu 
     370                375                380
Ala Glu Glu Glu Ser Ser Gly Gly Glu Glu Glu Asp Glu Asp Glu Asn 
 385                390                395                400
Ile Glu Val Val Tyr Ser Lys Ala Ala Ser Val Pro Lys Val Glu Thr 
                 405                410                415
Val Lys Ser Asp Asn Lys Asp Asp Asp Ile Asp Ile Asp Ala Ile 
             420                425                430



<210> 6596
<211> 487
<212> DNA
<213> Rattus norvegicus
<308> AI013297
<400> 6596

aaaggtcac  tttattagg  gattaaggg  tgcattatc  atggactat  aatagtgca  60
agctgacac  tcagtcaca  tcaagcaga  atgtagcca  ctccaacct  ttttgtaga  120
actcttgtt  ttttgttcc  agaaaagtt  gcaccgtaa  acttggact  gggtttcgg  180
accttcctc  cttccacgt  atagctcca  ccatgcttt  ctgcaaagg  aaccgcatc  240
tctttggca  tgaaggtga  aaccatgtt  gagagggga  cggccgttg  tgcccaacc  300
atcaaagga  tttcccatc  ctctctggt  tcaaactcc  tcttccatt  cttcgtgtt  360
tttactcca  actgcatgt  attgcgagc  ggaacaaag  ttctgacct  tctggtttt  420
atgtgctct  ctggaacac  agttagagg  gtaacatcc  ggatggaac  ctgcagacg  480
aaaccgc  487



<210> 6597
<211> 162
<212> PRT
<213> Rattus norvegicus
<308> NP_035017
<400> 6597

Met Leu Gly Arg Arg Ala Met Ala Thr Ala Ala Val Ser Val Cys Arg 
  1               5                  10                  15
Val Pro Ser Arg Leu Leu Ser Thr Ser Thr Trp Lys Leu Ala Asp Asn 
             20                  25                  30
Gln Thr Arg Asp Thr Gln Leu Ile Thr Val Asp Glu Lys Leu Asp Ile 
         35                  40                  45
Thr Thr Leu Thr Gly Val Pro Glu Glu His Ile Lys Thr Arg Lys Val 
     50                  55                  60
Arg Ile Phe Val Pro Ala Arg Asn Asn Met Gln Ser Gly Val Asn Asn 
 65                  70                  75                  80
Thr Lys Lys Trp Lys Met Glu Phe Asp Thr Arg Glu Arg Trp Glu Asn 
                 85                  90                  95
Pro Leu Met Gly Trp Ala Ser Thr Ala Asp Pro Leu Ser Asn Met Val 
             100                105                110
Leu Thr Phe Ser Ala Lys Glu Asp Ala Ile Ala Phe Ala Glu Lys Asn 
         115                120                125
Gly Trp Ser Tyr Asp Val Glu Glu Lys Lys Val Pro Lys Pro Lys Ser 
     130                135                140
Lys Ser Tyr Gly Ala Asn Phe Ser Trp Asn Lys Arg Thr Arg Val Ser 
 145                150                155                160
Thr Lys 
                 165



<210> 6598
<211> 631
<212> DNA
<213> Homo sapiens
<308> BC005270
<400> 6598

atcctggcg  ttgcctgca  caagatggc  gcggtctca  tgtcagtgg  actgaggca  60
acgttgtgg  ggagaaggg  agtggctgt  gctgccctt  ccgtttcca  ggttccgac  120
aggtcgttg  ggacttcct  atggagatt  gcacaggac  agactcaag  cacacaact  180
ataacagtt  atgaaaaat  ggatatcac  actttaact  gcgttccag  agagcatat  240
aaaactaga  aagtcagga  ctttgttcc  gctcgcaat  acatgcagt  tggagtaaa  300
aacacaaag  aatggaaga  ggagtttga  accagggag  gatgggaaa  tcctttgat  360
ggttgggca  caacggctg  tcccttatc  aacatggtt  taaccttca  tactaaaga  420
gatgcagtt  cctttgcag  aaaaaatgg  tggagctat  acattgaag  gaggaaggt  480
ccaaaaccc  agtccaagt  ttatggtgc  aacttttct  ggaacaaaa  aacaagagt  540
tccacaaaa  aggttggca  tgactatat  tctgcttga  tgtgaataa  gtcagctat  600
caaaaaaaa  aaaaaaaaa  aaaaaaaaa  a  631



<210> 6599
<211> 175
<212> PRT
<213> Homo sapiens
<308> O43181
<400> 6599

Met Ala Ala Val Ser Met Ser Val Val Leu Arg Gln Thr Leu Trp Arg 
  1               5                  10                  15
Arg Arg Ala Val Ala Val Ala Ala Leu Ser Val Ser Arg Val Pro Thr 
             20                  25                  30
Arg Ser Leu Arg Thr Ser Thr Trp Arg Leu Ala Gln Asp Gln Thr Gln 
         35                  40                  45
Asp Thr Gln Leu Ile Thr Val Asp Glu Lys Leu Asp Ile Thr Thr Leu 
     50                  55                  60
Thr Gly Val Pro Glu Glu His Ile Lys Thr Arg Lys Val Arg Ile Phe 
 65                  70                  75                  80
Val Pro Ala Arg Asn Asn Met Gln Ser Gly Val Asn Asn Thr Lys Lys 
                 85                  90                  95
Trp Lys Met Glu Phe Asp Thr Arg Glu Arg Trp Glu Asn Pro Leu Met 
             100                105                110
Gly Trp Ala Ser Thr Ala Asp Pro Leu Ser Asn Met Val Leu Thr Phe 
         115                120                125
Ser Thr Lys Glu Asp Ala Val Ser Phe Ala Glu Lys Asn Gly Trp Ser 
     130                135                140
Tyr Asp Ile Glu Glu Arg Lys Val Pro Lys Pro Lys Ser Lys Ser Tyr 
 145                150                155                160
Gly Ala Asn Phe Ser Trp Asn Lys Arg Thr Arg Val Ser Thr Lys 
                 165                170                175



<210> 6600
<211> 487
<212> DNA
<213> Rattus norvegicus
<308> AI013297
<400> 6600

aaaggtcac  tttattagg  gattaaggg  tgcattatc  atggactat  aatagtgca  60
agctgacac  tcagtcaca  tcaagcaga  atgtagcca  ctccaacct  ttttgtaga  120
actcttgtt  ttttgttcc  agaaaagtt  gcaccgtaa  acttggact  gggtttcgg  180
accttcctc  cttccacgt  atagctcca  ccatgcttt  ctgcaaagg  aaccgcatc  240
tctttggca  tgaaggtga  aaccatgtt  gagagggga  cggccgttg  tgcccaacc  300
atcaaagga  tttcccatc  ctctctggt  tcaaactcc  tcttccatt  cttcgtgtt  360
tttactcca  actgcatgt  attgcgagc  ggaacaaag  ttctgacct  tctggtttt  420
atgtgctct  ctggaacac  agttagagg  gtaacatcc  ggatggaac  ctgcagacg  480
aaaccgc  487



<210> 6601
<211> 162
<212> PRT
<213> Rattus norvegicus
<308> NP_035017
<400> 6601

Met Leu Gly Arg Arg Ala Met Ala Thr Ala Ala Val Ser Val Cys Arg 
  1               5                  10                  15
Val Pro Ser Arg Leu Leu Ser Thr Ser Thr Trp Lys Leu Ala Asp Asn 
             20                  25                  30
Gln Thr Arg Asp Thr Gln Leu Ile Thr Val Asp Glu Lys Leu Asp Ile 
         35                  40                  45
Thr Thr Leu Thr Gly Val Pro Glu Glu His Ile Lys Thr Arg Lys Val 
     50                  55                  60
Arg Ile Phe Val Pro Ala Arg Asn Asn Met Gln Ser Gly Val Asn Asn 
 65                  70                  75                  80
Thr Lys Lys Trp Lys Met Glu Phe Asp Thr Arg Glu Arg Trp Glu Asn 
                 85                  90                  95
Pro Leu Met Gly Trp Ala Ser Thr Ala Asp Pro Leu Ser Asn Met Val 
             100                105                110
Leu Thr Phe Ser Ala Lys Glu Asp Ala Ile Ala Phe Ala Glu Lys Asn 
         115                120                125
Gly Trp Ser Tyr Asp Val Glu Glu Lys Lys Val Pro Lys Pro Lys Ser 
     130                135                140
Lys Ser Tyr Gly Ala Asn Phe Ser Trp Asn Lys Arg Thr Arg Val Ser 
 145                150                155                160
Thr Lys 
                 165



<210> 6602
<211> 631
<212> DNA
<213> Homo sapiens
<308> BC005270
<400> 6602

atcctggcg  ttgcctgca  caagatggc  gcggtctca  tgtcagtgg  actgaggca  60
acgttgtgg  ggagaaggg  agtggctgt  gctgccctt  ccgtttcca  ggttccgac  120
aggtcgttg  ggacttcct  atggagatt  gcacaggac  agactcaag  cacacaact  180
ataacagtt  atgaaaaat  ggatatcac  actttaact  gcgttccag  agagcatat  240
aaaactaga  aagtcagga  ctttgttcc  gctcgcaat  acatgcagt  tggagtaaa  300
aacacaaag  aatggaaga  ggagtttga  accagggag  gatgggaaa  tcctttgat  360
ggttgggca  caacggctg  tcccttatc  aacatggtt  taaccttca  tactaaaga  420
gatgcagtt  cctttgcag  aaaaaatgg  tggagctat  acattgaag  gaggaaggt  480
ccaaaaccc  agtccaagt  ttatggtgc  aacttttct  ggaacaaaa  aacaagagt  540
tccacaaaa  aggttggca  tgactatat  tctgcttga  tgtgaataa  gtcagctat  600
caaaaaaaa  aaaaaaaaa  aaaaaaaaa  a  631



<210> 6603
<211> 175
<212> PRT
<213> Homo sapiens
<308> O43181
<400> 6603

Met Ala Ala Val Ser Met Ser Val Val Leu Arg Gln Thr Leu Trp Arg 
  1               5                  10                  15
Arg Arg Ala Val Ala Val Ala Ala Leu Ser Val Ser Arg Val Pro Thr 
             20                  25                  30
Arg Ser Leu Arg Thr Ser Thr Trp Arg Leu Ala Gln Asp Gln Thr Gln 
         35                  40                  45
Asp Thr Gln Leu Ile Thr Val Asp Glu Lys Leu Asp Ile Thr Thr Leu 
     50                  55                  60
Thr Gly Val Pro Glu Glu His Ile Lys Thr Arg Lys Val Arg Ile Phe 
 65                  70                  75                  80
Val Pro Ala Arg Asn Asn Met Gln Ser Gly Val Asn Asn Thr Lys Lys 
                 85                  90                  95
Trp Lys Met Glu Phe Asp Thr Arg Glu Arg Trp Glu Asn Pro Leu Met 
             100                105                110
Gly Trp Ala Ser Thr Ala Asp Pro Leu Ser Asn Met Val Leu Thr Phe 
         115                120                125
Ser Thr Lys Glu Asp Ala Val Ser Phe Ala Glu Lys Asn Gly Trp Ser 
     130                135                140
Tyr Asp Ile Glu Glu Arg Lys Val Pro Lys Pro Lys Ser Lys Ser Tyr 
 145                150                155                160
Gly Ala Asn Phe Ser Trp Asn Lys Arg Thr Arg Val Ser Thr Lys 
                 165                170                175



<210> 6604
<211> 487
<212> DNA
<213> Rattus norvegicus
<308> AI013297
<400> 6604

aaaggtcac  tttattagg  gattaaggg  tgcattatc  atggactat  aatagtgca  60
agctgacac  tcagtcaca  tcaagcaga  atgtagcca  ctccaacct  ttttgtaga  120
actcttgtt  ttttgttcc  agaaaagtt  gcaccgtaa  acttggact  gggtttcgg  180
accttcctc  cttccacgt  atagctcca  ccatgcttt  ctgcaaagg  aaccgcatc  240
tctttggca  tgaaggtga  aaccatgtt  gagagggga  cggccgttg  tgcccaacc  300
atcaaagga  tttcccatc  ctctctggt  tcaaactcc  tcttccatt  cttcgtgtt  360
tttactcca  actgcatgt  attgcgagc  ggaacaaag  ttctgacct  tctggtttt  420
atgtgctct  ctggaacac  agttagagg  gtaacatcc  ggatggaac  ctgcagacg  480
aaaccgc  487



<210> 6605
<211> 162
<212> PRT
<213> Rattus norvegicus
<308> NP_035017
<400> 6605

Met Leu Gly Arg Arg Ala Met Ala Thr Ala Ala Val Ser Val Cys Arg 
  1               5                  10                  15
Val Pro Ser Arg Leu Leu Ser Thr Ser Thr Trp Lys Leu Ala Asp Asn 
             20                  25                  30
Gln Thr Arg Asp Thr Gln Leu Ile Thr Val Asp Glu Lys Leu Asp Ile 
         35                  40                  45
Thr Thr Leu Thr Gly Val Pro Glu Glu His Ile Lys Thr Arg Lys Val 
     50                  55                  60
Arg Ile Phe Val Pro Ala Arg Asn Asn Met Gln Ser Gly Val Asn Asn 
 65                  70                  75                  80
Thr Lys Lys Trp Lys Met Glu Phe Asp Thr Arg Glu Arg Trp Glu Asn 
                 85                  90                  95
Pro Leu Met Gly Trp Ala Ser Thr Ala Asp Pro Leu Ser Asn Met Val 
             100                105                110
Leu Thr Phe Ser Ala Lys Glu Asp Ala Ile Ala Phe Ala Glu Lys Asn 
         115                120                125
Gly Trp Ser Tyr Asp Val Glu Glu Lys Lys Val Pro Lys Pro Lys Ser 
     130                135                140
Lys Ser Tyr Gly Ala Asn Phe Ser Trp Asn Lys Arg Thr Arg Val Ser 
 145                150                155                160
Thr Lys 
                 165



<210> 6606
<211> 631
<212> DNA
<213> Homo sapiens
<308> BC005270
<400> 6606

atcctggcg  ttgcctgca  caagatggc  gcggtctca  tgtcagtgg  actgaggca  60
acgttgtgg  ggagaaggg  agtggctgt  gctgccctt  ccgtttcca  ggttccgac  120
aggtcgttg  ggacttcct  atggagatt  gcacaggac  agactcaag  cacacaact  180
ataacagtt  atgaaaaat  ggatatcac  actttaact  gcgttccag  agagcatat  240
aaaactaga  aagtcagga  ctttgttcc  gctcgcaat  acatgcagt  tggagtaaa  300
aacacaaag  aatggaaga  ggagtttga  accagggag  gatgggaaa  tcctttgat  360
ggttgggca  caacggctg  tcccttatc  aacatggtt  taaccttca  tactaaaga  420
gatgcagtt  cctttgcag  aaaaaatgg  tggagctat  acattgaag  gaggaaggt  480
ccaaaaccc  agtccaagt  ttatggtgc  aacttttct  ggaacaaaa  aacaagagt  540
tccacaaaa  aggttggca  tgactatat  tctgcttga  tgtgaataa  gtcagctat  600
caaaaaaaa  aaaaaaaaa  aaaaaaaaa  a  631



<210> 6607
<211> 175
<212> PRT
<213> Homo sapiens
<308> O43181
<400> 6607

Met Ala Ala Val Ser Met Ser Val Val Leu Arg Gln Thr Leu Trp Arg 
  1               5                  10                  15
Arg Arg Ala Val Ala Val Ala Ala Leu Ser Val Ser Arg Val Pro Thr 
             20                  25                  30
Arg Ser Leu Arg Thr Ser Thr Trp Arg Leu Ala Gln Asp Gln Thr Gln 
         35                  40                  45
Asp Thr Gln Leu Ile Thr Val Asp Glu Lys Leu Asp Ile Thr Thr Leu 
     50                  55                  60
Thr Gly Val Pro Glu Glu His Ile Lys Thr Arg Lys Val Arg Ile Phe 
 65                  70                  75                  80
Val Pro Ala Arg Asn Asn Met Gln Ser Gly Val Asn Asn Thr Lys Lys 
                 85                  90                  95
Trp Lys Met Glu Phe Asp Thr Arg Glu Arg Trp Glu Asn Pro Leu Met 
             100                105                110
Gly Trp Ala Ser Thr Ala Asp Pro Leu Ser Asn Met Val Leu Thr Phe 
         115                120                125
Ser Thr Lys Glu Asp Ala Val Ser Phe Ala Glu Lys Asn Gly Trp Ser 
     130                135                140
Tyr Asp Ile Glu Glu Arg Lys Val Pro Lys Pro Lys Ser Lys Ser Tyr 
 145                150                155                160
Gly Ala Asn Phe Ser Trp Asn Lys Arg Thr Arg Val Ser Thr Lys 
                 165                170                175



<210> 6608
<211> 487
<212> DNA
<213> Rattus norvegicus
<308> AI013297
<400> 6608

aaaggtcac  tttattagg  gattaaggg  tgcattatc  atggactat  aatagtgca  60
agctgacac  tcagtcaca  tcaagcaga  atgtagcca  ctccaacct  ttttgtaga  120
actcttgtt  ttttgttcc  agaaaagtt  gcaccgtaa  acttggact  gggtttcgg  180
accttcctc  cttccacgt  atagctcca  ccatgcttt  ctgcaaagg  aaccgcatc  240
tctttggca  tgaaggtga  aaccatgtt  gagagggga  cggccgttg  tgcccaacc  300
atcaaagga  tttcccatc  ctctctggt  tcaaactcc  tcttccatt  cttcgtgtt  360
tttactcca  actgcatgt  attgcgagc  ggaacaaag  ttctgacct  tctggtttt  420
atgtgctct  ctggaacac  agttagagg  gtaacatcc  ggatggaac  ctgcagacg  480
aaaccgc  487



<210> 6609
<211> 162
<212> PRT
<213> Rattus norvegicus
<308> NP_035017
<400> 6609

Met Leu Gly Arg Arg Ala Met Ala Thr Ala Ala Val Ser Val Cys Arg 
  1               5                  10                  15
Val Pro Ser Arg Leu Leu Ser Thr Ser Thr Trp Lys Leu Ala Asp Asn 
             20                  25                  30
Gln Thr Arg Asp Thr Gln Leu Ile Thr Val Asp Glu Lys Leu Asp Ile 
         35                  40                  45
Thr Thr Leu Thr Gly Val Pro Glu Glu His Ile Lys Thr Arg Lys Val 
     50                  55                  60
Arg Ile Phe Val Pro Ala Arg Asn Asn Met Gln Ser Gly Val Asn Asn 
 65                  70                  75                  80
Thr Lys Lys Trp Lys Met Glu Phe Asp Thr Arg Glu Arg Trp Glu Asn 
                 85                  90                  95
Pro Leu Met Gly Trp Ala Ser Thr Ala Asp Pro Leu Ser Asn Met Val 
             100                105                110
Leu Thr Phe Ser Ala Lys Glu Asp Ala Ile Ala Phe Ala Glu Lys Asn 
         115                120                125
Gly Trp Ser Tyr Asp Val Glu Glu Lys Lys Val Pro Lys Pro Lys Ser 
     130                135                140
Lys Ser Tyr Gly Ala Asn Phe Ser Trp Asn Lys Arg Thr Arg Val Ser 
 145                150                155                160
Thr Lys 
                 165



<210> 6610
<211> 631
<212> DNA
<213> Homo sapiens
<308> BC005270
<400> 6610

atcctggcg  ttgcctgca  caagatggc  gcggtctca  tgtcagtgg  actgaggca  60
acgttgtgg  ggagaaggg  agtggctgt  gctgccctt  ccgtttcca  ggttccgac  120
aggtcgttg  ggacttcct  atggagatt  gcacaggac  agactcaag  cacacaact  180
ataacagtt  atgaaaaat  ggatatcac  actttaact  gcgttccag  agagcatat  240
aaaactaga  aagtcagga  ctttgttcc  gctcgcaat  acatgcagt  tggagtaaa  300
aacacaaag  aatggaaga  ggagtttga  accagggag  gatgggaaa  tcctttgat  360
ggttgggca  caacggctg  tcccttatc  aacatggtt  taaccttca  tactaaaga  420
gatgcagtt  cctttgcag  aaaaaatgg  tggagctat  acattgaag  gaggaaggt  480
ccaaaaccc  agtccaagt  ttatggtgc  aacttttct  ggaacaaaa  aacaagagt  540
tccacaaaa  aggttggca  tgactatat  tctgcttga  tgtgaataa  gtcagctat  600
caaaaaaaa  aaaaaaaaa  aaaaaaaaa  a  631



<210> 6611
<211> 175
<212> PRT
<213> Homo sapiens
<308> O43181
<400> 6611

Met Ala Ala Val Ser Met Ser Val Val Leu Arg Gln Thr Leu Trp Arg 
  1               5                  10                  15
Arg Arg Ala Val Ala Val Ala Ala Leu Ser Val Ser Arg Val Pro Thr 
             20                  25                  30
Arg Ser Leu Arg Thr Ser Thr Trp Arg Leu Ala Gln Asp Gln Thr Gln 
         35                  40                  45
Asp Thr Gln Leu Ile Thr Val Asp Glu Lys Leu Asp Ile Thr Thr Leu 
     50                  55                  60
Thr Gly Val Pro Glu Glu His Ile Lys Thr Arg Lys Val Arg Ile Phe 
 65                  70                  75                  80
Val Pro Ala Arg Asn Asn Met Gln Ser Gly Val Asn Asn Thr Lys Lys 
                 85                  90                  95
Trp Lys Met Glu Phe Asp Thr Arg Glu Arg Trp Glu Asn Pro Leu Met 
             100                105                110
Gly Trp Ala Ser Thr Ala Asp Pro Leu Ser Asn Met Val Leu Thr Phe 
         115                120                125
Ser Thr Lys Glu Asp Ala Val Ser Phe Ala Glu Lys Asn Gly Trp Ser 
     130                135                140
Tyr Asp Ile Glu Glu Arg Lys Val Pro Lys Pro Lys Ser Lys Ser Tyr 
 145                150                155                160
Gly Ala Asn Phe Ser Trp Asn Lys Arg Thr Arg Val Ser Thr Lys 
                 165                170                175



<210> 6612
<211> 423
<212> DNA
<213> Rattus norvegicus
<308> AI013472
<400> 6612

aaatgtttt  aaaatccat  gggcaaaaa  cttttccct  cattctact  tctgatgag  60
ttggagagc  gcagggaca  gctgtcaag  agtcgcttc  gcagaaagt  ctctggagg  120
cgcagcacc  acaccatgt  gtggtgatt  ctcctgtcc  tgatgtcta  aggagacag  180
atctctctc  tgatcgcgg  ggcatgcag  gagagggtc  tcttagtct  gaagaggtc  240
gacacgaag  acactatgc  gcaggccac  agagctcct  gggcaaatc  tgccaggac  300
tcgctagga  ggtgtttgt  gtcagatac  cgtgacaat  ccgtgtaga  ggccatcat  360
agcaaagtg  actgcagga  ggggcggag  agccgggcc  cacgccagg  gaagcgggc  420
tgt  423



<210> 6613
<211> 312
<212> PRT
<213> Rattus norvegicus
<308> CAA69106
<400> 6613

Met Gln Ser Tyr Lys Tyr Asp Lys Ala Ile Val Pro Glu Ser Lys Asn 
  1               5                  10                  15
Gly Gly Ser Pro Ala Leu Asn Asn Asn Pro Arg Lys Gly Gly Ser Lys 
             20                  25                  30
Arg Val Leu Leu Ile Cys Leu Asp Leu Phe Cys Leu Phe Met Ala Ala 
         35                  40                  45
Leu Pro Phe Leu Ile Ile Glu Thr Ser Thr Ile Lys Pro Tyr Arg Arg 
     50                  55                  60
Gly Phe Tyr Cys Asn Asp Glu Ser Ile Lys Tyr Pro Leu Lys Val Ser 
 65                  70                  75                  80
Glu Thr Ile Asn Asp Ala Val Leu Cys Ala Val Gly Ile Val Ile Ala 
                 85                  90                  95
Ile Leu Arg Ile Ile Thr Gly Glu Phe Tyr Arg Ile Tyr Tyr Leu Lys 
             100                105                110
Glu Lys Ser Arg Ser Thr Ile Gln Asn Pro Tyr Val Ala Ala Leu Tyr 
         115                120                125
Lys Gln Val Gly Cys Phe Leu Phe Gly Cys Ala Ile Ser Gln Ser Phe 
     130                135                140
Thr Asp Ile Ala Lys Val Ser Ile Gly Arg Leu Arg Pro His Phe Leu 
 145                150                155                160
Ser Val Cys Asp Pro Asp Phe Ser Gln Ile Asn Cys Ser Glu Gly Tyr 
                 165                170                175
Ile Gln Asn Tyr Arg Cys Arg Gly Glu Asp Ser Lys Val Gln Glu Ala 
             180                185                190
Arg Lys Ser Phe Phe Ser Gly His Ala Ser Phe Ser Met Phe Thr Met 
         195                200                205
Leu Tyr Leu Val Leu Tyr Leu Gln Ala Arg Phe Thr Trp Arg Gly Ala 
     210                215                220
Arg Leu Leu Arg Pro Leu Leu Gln Phe Thr Leu Leu Met Met Ala Phe 
 225                230                235                240
Tyr Thr Gly Leu Ser Arg Val Ser Asp Tyr Lys His His Pro Ser Asp 
                 245                250                255
Val Leu Ala Gly Phe Ala Gln Gly Ala Leu Val Ala Cys Cys Ile Val 
             260                265                270
Phe Phe Val Ser Asp Leu Phe Lys Thr Lys Thr Thr Leu Ser Leu Pro 
         275                280                285
Ala Pro Ala Ile Arg Arg Glu Ile Leu Ser Pro Val Asp Ile Met Asp 
     290                295                300
Arg Ser Asn His His Asn Met Val 
 305                310



<210> 6614
<211> 1451
<212> DNA
<213> Homo sapiens
<308> NM_003713
<400> 6614

ggcacgagg  gaaggtggc  gagcgcccg  gctgcccac  cgctcgctc  cgcactcag  60
cgcgcgcca  aacagcgcg  cccaagctg  gcagctctg  aaaagtttc  gctcgggat  120
tggctctct  ccccttgga  tttagaacg  tttagggtt  acagaggaa  gcagaggcg  180
gcaggagga  cagaaaaca  caccttctg  agttggagg  aggcagccc  ggctgcact  240
tagccgccg  gcccggagc  ggggccgac  cgccactat  cgcagcagc  tcggccagg  300
ggcgacccg  gcgcctggg  gtgtggctg  tgttgcggg  cgtcttcgc  gggcgggag  360
ctcgcgccg  agccagcgc  atgcaaaac  acaagtacg  caaagcgat  gtcccggag  420
gcaagaacg  cggcagccc  gcgctcaac  acaacccga  gaggagcgg  agcaagcgg  480
tgctgctca  ctgcctcga  ctcttctgc  tcttcatgg  gggcctccc  ttcctcatc  540
tcgagacaa  caccatcaa  ccttaccac  gagggtttt  ctgcaatga  gagagcatc  600
agtacccac  gaaaactgg  gagacaata  atgacgctg  gctctgtgc  gtggggatc  660
tcattgcca  cctcgcgat  atcacgggg  aattctacc  gatctatta  ctgaagaag  720
cgcggtcga  gattcagaa  ccctacgtg  cagcactct  taagcaagt  ggctgcttc  780
tctttggct  tgccatcag  cagtctttc  cagacattg  caaagtgtc  atagggcgc  840
tgcgtcctc  cttcttgag  gtctgcaac  ctgatttca  ccagatcaa  tgctctgaa  900
gctacattc  gaactacag  tgcagaggt  atgacagca  agtccagga  gccaggaag  960
ccttcttct  tggccatgc  tccttctcc  tgtacacta  gctgtattt  gtgctatac  1020
tgcaggccc  cttcacttg  cgaggagcc  gcctgctcc  gcccctcct  cagttcacc  1080
tgatcatga  ggccttcta  acgggactg  ctcgcgtat  agaccacaa  caccatccc  1140
gtgatgttc  ggcaggatt  gctcaagga  ccctggtgg  ctgctgcat  gttttcttc  1200
tgtctgacc  cttcaagac  aagatgacg  tctccctgc  tgcccctgc  atccggaag  1260
aaatccttt  acctgtgga  attattgac  ggaacaatc  ccacaacat  atgtaggtg  1320
cacccacct  ctgagctgt  tttgtaaaa  gactgctga  agcaagttc  tgctgctct  1380
caatctcat  agacagtag  atgtaggga  aaacttttg  ccgactgat  tttaaaaaa  1440
aaaaaaaaa  a  1451



<210> 6615
<211> 311
<212> PRT
<213> Homo sapiens
<308> NP_003704
<400> 6615

Met Gln Asn Tyr Lys Tyr Asp Lys Ala Ile Val Pro Glu Ser Lys Asn 
  1               5                  10                  15
Gly Gly Ser Pro Ala Leu Asn Asn Asn Pro Arg Arg Ser Gly Ser Lys 
             20                  25                  30
Arg Val Leu Leu Ile Cys Leu Asp Leu Phe Cys Leu Phe Met Ala Gly 
         35                  40                  45
Leu Pro Phe Leu Ile Ile Glu Thr Ser Thr Ile Lys Pro Tyr His Arg 
     50                  55                  60
Gly Phe Tyr Cys Asn Asp Glu Ser Ile Lys Tyr Pro Leu Lys Thr Gly 
 65                  70                  75                  80
Glu Thr Ile Asn Asp Ala Val Leu Cys Ala Val Gly Ile Val Ile Ala 
                 85                  90                  95
Ile Leu Ala Ile Ile Thr Gly Glu Phe Tyr Arg Ile Tyr Tyr Leu Lys 
             100                105                110
Lys Ser Arg Ser Thr Ile Gln Asn Pro Tyr Val Ala Ala Leu Tyr Lys 
         115                120                125
Gln Val Gly Cys Phe Leu Phe Gly Cys Ala Ile Ser Gln Ser Phe Thr 
     130                135                140
Asp Ile Ala Lys Val Ser Ile Gly Arg Leu Arg Pro His Phe Leu Ser 
 145                150                155                160
Val Cys Asn Pro Asp Phe Ser Gln Ile Asn Cys Ser Glu Gly Tyr Ile 
                 165                170                175
Gln Asn Tyr Arg Cys Arg Gly Asp Asp Ser Lys Val Gln Glu Ala Arg 
             180                185                190
Lys Ser Phe Phe Ser Gly His Ala Ser Phe Ser Met Tyr Thr Met Leu 
         195                200                205
Tyr Leu Val Leu Tyr Leu Gln Ala Arg Phe Thr Trp Arg Gly Ala Arg 
     210                215                220
Leu Leu Arg Pro Leu Leu Gln Phe Thr Leu Ile Met Met Ala Phe Tyr 
 225                230                235                240
Thr Gly Leu Ser Arg Val Ser Asp His Lys His His Pro Ser Asp Val 
                 245                250                255
Leu Ala Gly Phe Ala Gln Gly Ala Leu Val Ala Cys Cys Ile Val Phe 
             260                265                270
Phe Val Ser Asp Leu Phe Lys Thr Lys Met Thr Leu Ser Leu Pro Ala 
         275                280                285
Pro Ala Ile Arg Lys Glu Ile Leu Ser Pro Val Asp Ile Ile Asp Arg 
     290                295                300
Asn Asn His His Asn Met Met 
 305                310



<210> 6616
<211> 399
<212> DNA
<213> Rattus norvegicus
<308> AI014087
<400> 6616

accgtataa  ttcagtttt  attttccat  gtatttttc  ttctgtctt  atgaaatca  60
ctctttaca  gggctttgg  ggaggtcgt  gtgcaacgc  agcaggtct  aatcgtggt  120
ggggtgttc  gtccttccg  gcctcacga  atcgattcc  gacaacctt  ctatgaatg  180
cacagctca  gcagtagtg  agcttgaca  agagcttgg  aagcacgta  gcgtcgaag  240
cgcttgctt  agatatgtc  ctgactgca  cggcttcta  aatgttccg  atgacaaac  300
tcttaatgg  cttatcctt  ggcacgcac  gggcgcagt  cgtgcagcg  attggttgc  360
catggccgc  ggccttttt  gcacgaccg  tgtttctcc  399



<210> 6617
<211> 115
<212> PRT
<213> Rattus norvegicus
<308> P02383
<400> 6617

Met Thr Lys Lys Arg Arg Asn Asn Gly Arg Ala Lys Lys Gly Arg Gly 
  1               5                  10                  15
His Val Gln Pro Ile Arg Cys Thr Asn Cys Ala Arg Cys Val Pro Lys 
             20                  25                  30
Asp Lys Ala Ile Lys Lys Phe Val Ile Arg Asn Ile Val Glu Ala Ala 
         35                  40                  45
Ala Val Arg Asp Ile Ser Glu Ala Ser Val Phe Asp Ala Tyr Val Leu 
     50                  55                  60
Pro Lys Leu Tyr Val Lys Leu His Tyr Cys Val Ser Cys Ala Ile His 
 65                  70                  75                  80
Ser Lys Val Val Arg Asn Arg Ser Arg Glu Ala Arg Lys Asp Arg Thr 
                 85                  90                  95
Pro Pro Pro Arg Phe Arg Pro Ala Gly Ala Ala Pro Arg Pro Pro Pro 
             100                105                110
Lys Pro Met 
         115



<210> 6618
<211> 217
<212> DNA
<213> Homo sapiens
<308> AW022506
<400> 6618

gcacgaggt  caattcaca  caaagtagt  aggaatcga  ctcgtgaag  ccgcaagga  60
cgaacaccc  caccccgat  tagacctgc  ggtgctgcc  cacgtcccc  accaaagcc  120
atgtaagga  ctgagttct  aaagactga  gacaggcta  tctctggag  aaaataaaa  180
ggaaattgt  cttaaaaaa  aaaaaaaaa  aannaaa  217



<210> 6619
<211> 410
<212> DNA
<213> Rattus norvegicus
<308> AI014135
<400> 6619

agaacaaca  atcaaaatg  aaacttaaa  tataaccaa  agagggaca  ctctttagg  60
aaaggaaaa  accttaaat  gtgaataaa  aactacaac  acttaacca  tgtaggctt  120
aaagcagcc  tcaataaag  aagcgttca  gctcaacat  catacttac  cacactaat  180
ccacaaacc  caataaatt  ctatattac  aattgggct  atctataga  ccatagatg  240
aatactgtt  atatgagta  caagaacca  ttctcctag  acaagtgta  gacaacccg  300
ataaccatt  tcaattatc  aatcatagg  actaaccca  caataaaat  acctatccc  360
aactcgtta  cccaacaca  gcgtgcttt  aggaaagat  aacaaaaaaa  410



<210> 6620
<211> 2201
<212> DNA
<213> Homo sapiens
<308> L22009
<400> 6620

ttttttttt  cgtcttagc  acgcagaag  cgcgtgtct  gtttgtttc  acgccggac  60
gcgtaagag  cgatgatgt  gggcacgga  ggtggagag  gattcgtgg  gaaggtccg  120
ggcttgccc  ggtcttgct  ggccgatga  gtgcagagg  ttttttctg  ctgcaaaat  180
caaaatggg  ctcaaggta  tcgtttcat  tacaccaga  aaggcagac  aagtggcga  240
gcttttgtt  aacttgaat  agaagatga  gtcaaattg  ccctgaaaa  agacagaga  300
actatggga  acagatatg  tgaagtatt  aagtcaaac  acgttgaaa  ggattgggt  360
ttgaagcat  ctggtccaa  tagtcctga  acggccaat  atggctttg  acggcttag  420
ggacttccc  ttggatgta  caaggaaga  attgttcag  tcttctcag  gttggaaat  480
gtgccaaat  ggataacat  gccggtgga  ttccagggg  ggagtacgg  ggaggcctt  540
gtgcagttt  cttcacagg  aatagctga  aaggctcta  agaaacaca  ggaaagaat  600
gggcacagg  atattgaaa  ctttaagag  agtagagct  aagttagaa  tcattatga  660
ccaccacga  agcttatgg  catgcagcg  ccaggtcct  atgacagac  tggggctgg  720
agagggtat  acagcattg  cagaggagc  ggctttgag  ggatgaggc  tggtgctta  780
ggtggaggc  atggaggct  tgatgatta  aatggctat  atgatggct  tggatttgg  840
tcagataga  ttggaagag  cctcaatta  tgtttttca  gaatgtctg  tcacagata  900
ggggatggt  gctctactt  ccagagcac  acaggacac  gtgtacaca  gcggggatt  960
ccttacaga  ctactgaga  tgacattta  aattttttt  caccgctca  ccctgtgag  1020
gtacacatt  aaattggtc  tgatggcag  gtaactggt  aagcagatg  cgagttcgc  1080
actcatgaa  atgctgtgg  agctatgtc  aaagacaaa  caaatatgc  acacagata  1140
gtagaactc  tcttgaatt  tacagcagg  gcaagcggt  gtgcttacg  acacagata  1200
gtagaactc  tcttgaatt  tacagcagg  gcaagcggt  gtgcttatg  tagccaaat  1260
atgggaggc  tgggcttgt  aaaccagtc  agctacggg  gcccagcca  ccagcagct  1320
agtgggggt  acggaggcg  ctacggtgg  cagagcagc  tgagtggat  cgaccaagt  1380
ttacaggaa  actccagtg  ttttcaatc  aacattgca  aggtaacca  ggagcagtg  1440
acagcagct  ctacagtag  ggaagccgt  catctatgg  cgtgaacgg  atgggaggg  1500
tgtctagca  gtccagtat  agtggtgga  ggggaatgt  attgatcga  cctgatcac  1560
gactcttgg  caacctttt  ttttttttt  ttttcttta  gaaaacttc  gtttaacag  1620
ttctgcaat  caagcttgt  atttatgct  actctaagt  gaaatcagg  ttgttatga  1680
gacttaagg  ccagtattt  tgaatacaa  actcatcta  gatgtaaca  tgaagctga  1740
taaactata  ctgttaaac  taagttcca  cttttctca  gttagttat  ggatgtact  1800
aagcagtaa  cgtatttag  taaaagcag  tgaattatg  taaatgttg  cctttgcca  1860
gttaaattg  acactgttt  ggatgcatg  tgaaagaca  gcttttatt  tttttgtaa  1920
acaatatag  agctgtgtc  actattaaa  gtgaaacat  ttggcatgt  tgttaattc  1980
agtttcatt  aataacctg  aaggcacgt  agtttaagc  ttttttttt  ttaagttaa  2040
gggaaaaat  tgagacgca  taccaatac  taggatttt  gtcttggtg  ttgtatgaa  2100
ttctgaggc  ttgatttaa  tctttcatt  tattgtgat  tccttttag  tatattgcg  2160
taagtgaaa  ttgtcaaat  aatcctcct  ttaaaaact  c  2201



<210> 6621
<211> 449
<212> PRT
<213> Homo sapiens
<308> P31943
<400> 6621

Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
  1               5                  10                  15
Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
             20                  25                  30
Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
         35                  40                  45
Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
     50                  55                  60
Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
 65                  70                  75                  80
Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                 85                  90                  95
Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
             100                105                110
Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
         115                120                125
Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
     130                135                140
Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
 145                150                155                160
Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                 165                170                175
Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
             180                185                190
Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
         195                200                205
Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
     210                215                220
Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
 225                230                235                240
Gly Gly Tyr Asp Asp Tyr Asn Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                 245                250                255
Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
             260                265                270
Asp His Arg Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr Thr Gly 
         275                280                285
His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
     290                295                300
Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
 305                310                315                320
Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                 325                330                335
Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Ala Asn Met 
             340                345                350
Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Ala Ser 
         355                360                365
Gly Gly Ala Tyr Glu His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr 
     370                375                380
Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
 385                390                395                400
Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                 405                410                415
Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
             420                425                430
Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser Asn Ile 
         435                440                445
Ala 
     450



<210> 6622
<211> 410
<212> DNA
<213> Rattus norvegicus
<308> AI014135
<400> 6622

agaacaaca  atcaaaatg  aaacttaaa  tataaccaa  agagggaca  ctctttagg  60
aaaggaaaa  accttaaat  gtgaataaa  aactacaac  acttaacca  tgtaggctt  120
aaagcagcc  tcaataaag  aagcgttca  gctcaacat  catacttac  cacactaat  180
ccacaaacc  caataaatt  ctatattac  aattgggct  atctataga  ccatagatg  240
aatactgtt  atatgagta  caagaacca  ttctcctag  acaagtgta  gacaacccg  300
ataaccatt  tcaattatc  aatcatagg  actaaccca  caataaaat  acctatccc  360
aactcgtta  cccaacaca  gcgtgcttt  aggaaagat  aacaaaaaaa  410



<210> 6623
<211> 2201
<212> DNA
<213> Homo sapiens
<308> L22009
<400> 6623

ttttttttt  cgtcttagc  acgcagaag  cgcgtgtct  gtttgtttc  acgccggac  60
gcgtaagag  cgatgatgt  gggcacgga  ggtggagag  gattcgtgg  gaaggtccg  120
ggcttgccc  ggtcttgct  ggccgatga  gtgcagagg  ttttttctg  ctgcaaaat  180
caaaatggg  ctcaaggta  tcgtttcat  tacaccaga  aaggcagac  aagtggcga  240
gcttttgtt  aacttgaat  agaagatga  gtcaaattg  ccctgaaaa  agacagaga  300
actatggga  acagatatg  tgaagtatt  aagtcaaac  acgttgaaa  ggattgggt  360
ttgaagcat  ctggtccaa  tagtcctga  acggccaat  atggctttg  acggcttag  420
ggacttccc  ttggatgta  caaggaaga  attgttcag  tcttctcag  gttggaaat  480
gtgccaaat  ggataacat  gccggtgga  ttccagggg  ggagtacgg  ggaggcctt  540
gtgcagttt  cttcacagg  aatagctga  aaggctcta  agaaacaca  ggaaagaat  600
gggcacagg  atattgaaa  ctttaagag  agtagagct  aagttagaa  tcattatga  660
ccaccacga  agcttatgg  catgcagcg  ccaggtcct  atgacagac  tggggctgg  720
agagggtat  acagcattg  cagaggagc  ggctttgag  ggatgaggc  tggtgctta  780
ggtggaggc  atggaggct  tgatgatta  aatggctat  atgatggct  tggatttgg  840
tcagataga  ttggaagag  cctcaatta  tgtttttca  gaatgtctg  tcacagata  900
ggggatggt  gctctactt  ccagagcac  acaggacac  gtgtacaca  gcggggatt  960
ccttacaga  ctactgaga  tgacattta  aattttttt  caccgctca  ccctgtgag  1020
gtacacatt  aaattggtc  tgatggcag  gtaactggt  aagcagatg  cgagttcgc  1080
actcatgaa  atgctgtgg  agctatgtc  aaagacaaa  caaatatgc  acacagata  1140
gtagaactc  tcttgaatt  tacagcagg  gcaagcggt  gtgcttacg  acacagata  1200
gtagaactc  tcttgaatt  tacagcagg  gcaagcggt  gtgcttatg  tagccaaat  1260
atgggaggc  tgggcttgt  aaaccagtc  agctacggg  gcccagcca  ccagcagct  1320
agtgggggt  acggaggcg  ctacggtgg  cagagcagc  tgagtggat  cgaccaagt  1380
ttacaggaa  actccagtg  ttttcaatc  aacattgca  aggtaacca  ggagcagtg  1440
acagcagct  ctacagtag  ggaagccgt  catctatgg  cgtgaacgg  atgggaggg  1500
tgtctagca  gtccagtat  agtggtgga  ggggaatgt  attgatcga  cctgatcac  1560
gactcttgg  caacctttt  ttttttttt  ttttcttta  gaaaacttc  gtttaacag  1620
ttctgcaat  caagcttgt  atttatgct  actctaagt  gaaatcagg  ttgttatga  1680
gacttaagg  ccagtattt  tgaatacaa  actcatcta  gatgtaaca  tgaagctga  1740
taaactata  ctgttaaac  taagttcca  cttttctca  gttagttat  ggatgtact  1800
aagcagtaa  cgtatttag  taaaagcag  tgaattatg  taaatgttg  cctttgcca  1860
gttaaattg  acactgttt  ggatgcatg  tgaaagaca  gcttttatt  tttttgtaa  1920
acaatatag  agctgtgtc  actattaaa  gtgaaacat  ttggcatgt  tgttaattc  1980
agtttcatt  aataacctg  aaggcacgt  agtttaagc  ttttttttt  ttaagttaa  2040
gggaaaaat  tgagacgca  taccaatac  taggatttt  gtcttggtg  ttgtatgaa  2100
ttctgaggc  ttgatttaa  tctttcatt  tattgtgat  tccttttag  tatattgcg  2160
taagtgaaa  ttgtcaaat  aatcctcct  ttaaaaact  c  2201



<210> 6624
<211> 449
<212> PRT
<213> Homo sapiens
<308> P31943
<400> 6624

Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
  1               5                  10                  15
Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
             20                  25                  30
Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
         35                  40                  45
Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
     50                  55                  60
Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
 65                  70                  75                  80
Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                 85                  90                  95
Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
             100                105                110
Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
         115                120                125
Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
     130                135                140
Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
 145                150                155                160
Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                 165                170                175
Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
             180                185                190
Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
         195                200                205
Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
     210                215                220
Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
 225                230                235                240
Gly Gly Tyr Asp Asp Tyr Asn Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                 245                250                255
Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
             260                265                270
Asp His Arg Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr Thr Gly 
         275                280                285
His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
     290                295                300
Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
 305                310                315                320
Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                 325                330                335
Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Ala Asn Met 
             340                345                350
Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Ala Ser 
         355                360                365
Gly Gly Ala Tyr Glu His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr 
     370                375                380
Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
 385                390                395                400
Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                 405                410                415
Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
             420                425                430
Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser Asn Ile 
         435                440                445
Ala 
     450



<210> 6625
<211> 410
<212> DNA
<213> Rattus norvegicus
<308> AI014135
<400> 6625

agaacaaca  atcaaaatg  aaacttaaa  tataaccaa  agagggaca  ctctttagg  60
aaaggaaaa  accttaaat  gtgaataaa  aactacaac  acttaacca  tgtaggctt  120
aaagcagcc  tcaataaag  aagcgttca  gctcaacat  catacttac  cacactaat  180
ccacaaacc  caataaatt  ctatattac  aattgggct  atctataga  ccatagatg  240
aatactgtt  atatgagta  caagaacca  ttctcctag  acaagtgta  gacaacccg  300
ataaccatt  tcaattatc  aatcatagg  actaaccca  caataaaat  acctatccc  360
aactcgtta  cccaacaca  gcgtgcttt  aggaaagat  aacaaaaaaa  410



<210> 6626
<211> 2201
<212> DNA
<213> Homo sapiens
<308> L22009
<400> 6626

ttttttttt  cgtcttagc  acgcagaag  cgcgtgtct  gtttgtttc  acgccggac  60
gcgtaagag  cgatgatgt  gggcacgga  ggtggagag  gattcgtgg  gaaggtccg  120
ggcttgccc  ggtcttgct  ggccgatga  gtgcagagg  ttttttctg  ctgcaaaat  180
caaaatggg  ctcaaggta  tcgtttcat  tacaccaga  aaggcagac  aagtggcga  240
gcttttgtt  aacttgaat  agaagatga  gtcaaattg  ccctgaaaa  agacagaga  300
actatggga  acagatatg  tgaagtatt  aagtcaaac  acgttgaaa  ggattgggt  360
ttgaagcat  ctggtccaa  tagtcctga  acggccaat  atggctttg  acggcttag  420
ggacttccc  ttggatgta  caaggaaga  attgttcag  tcttctcag  gttggaaat  480
gtgccaaat  ggataacat  gccggtgga  ttccagggg  ggagtacgg  ggaggcctt  540
gtgcagttt  cttcacagg  aatagctga  aaggctcta  agaaacaca  ggaaagaat  600
gggcacagg  atattgaaa  ctttaagag  agtagagct  aagttagaa  tcattatga  660
ccaccacga  agcttatgg  catgcagcg  ccaggtcct  atgacagac  tggggctgg  720
agagggtat  acagcattg  cagaggagc  ggctttgag  ggatgaggc  tggtgctta  780
ggtggaggc  atggaggct  tgatgatta  aatggctat  atgatggct  tggatttgg  840
tcagataga  ttggaagag  cctcaatta  tgtttttca  gaatgtctg  tcacagata  900
ggggatggt  gctctactt  ccagagcac  acaggacac  gtgtacaca  gcggggatt  960
ccttacaga  ctactgaga  tgacattta  aattttttt  caccgctca  ccctgtgag  1020
gtacacatt  aaattggtc  tgatggcag  gtaactggt  aagcagatg  cgagttcgc  1080
actcatgaa  atgctgtgg  agctatgtc  aaagacaaa  caaatatgc  acacagata  1140
gtagaactc  tcttgaatt  tacagcagg  gcaagcggt  gtgcttacg  acacagata  1200
gtagaactc  tcttgaatt  tacagcagg  gcaagcggt  gtgcttatg  tagccaaat  1260
atgggaggc  tgggcttgt  aaaccagtc  agctacggg  gcccagcca  ccagcagct  1320
agtgggggt  acggaggcg  ctacggtgg  cagagcagc  tgagtggat  cgaccaagt  1380
ttacaggaa  actccagtg  ttttcaatc  aacattgca  aggtaacca  ggagcagtg  1440
acagcagct  ctacagtag  ggaagccgt  catctatgg  cgtgaacgg  atgggaggg  1500
tgtctagca  gtccagtat  agtggtgga  ggggaatgt  attgatcga  cctgatcac  1560
gactcttgg  caacctttt  ttttttttt  ttttcttta  gaaaacttc  gtttaacag  1620
ttctgcaat  caagcttgt  atttatgct  actctaagt  gaaatcagg  ttgttatga  1680
gacttaagg  ccagtattt  tgaatacaa  actcatcta  gatgtaaca  tgaagctga  1740
taaactata  ctgttaaac  taagttcca  cttttctca  gttagttat  ggatgtact  1800
aagcagtaa  cgtatttag  taaaagcag  tgaattatg  taaatgttg  cctttgcca  1860
gttaaattg  acactgttt  ggatgcatg  tgaaagaca  gcttttatt  tttttgtaa  1920
acaatatag  agctgtgtc  actattaaa  gtgaaacat  ttggcatgt  tgttaattc  1980
agtttcatt  aataacctg  aaggcacgt  agtttaagc  ttttttttt  ttaagttaa  2040
gggaaaaat  tgagacgca  taccaatac  taggatttt  gtcttggtg  ttgtatgaa  2100
ttctgaggc  ttgatttaa  tctttcatt  tattgtgat  tccttttag  tatattgcg  2160
taagtgaaa  ttgtcaaat  aatcctcct  ttaaaaact  c  2201



<210> 6627
<211> 449
<212> PRT
<213> Homo sapiens
<308> P31943
<400> 6627

Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
  1               5                  10                  15
Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
             20                  25                  30
Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
         35                  40                  45
Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
     50                  55                  60
Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
 65                  70                  75                  80
Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                 85                  90                  95
Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
             100                105                110
Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
         115                120                125
Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
     130                135                140
Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
 145                150                155                160
Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                 165                170                175
Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
             180                185                190
Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
         195                200                205
Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
     210                215                220
Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
 225                230                235                240
Gly Gly Tyr Asp Asp Tyr Asn Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                 245                250                255
Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
             260                265                270
Asp His Arg Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr Thr Gly 
         275                280                285
His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
     290                295                300
Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
 305                310                315                320
Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                 325                330                335
Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Ala Asn Met 
             340                345                350
Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Ala Ser 
         355                360                365
Gly Gly Ala Tyr Glu His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr 
     370                375                380
Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
 385                390                395                400
Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                 405                410                415
Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
             420                425                430
Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser Asn Ile 
         435                440                445
Ala 
     450



<210> 6628
<211> 410
<212> DNA
<213> Rattus norvegicus
<308> AI014135
<400> 6628

agaacaaca  atcaaaatg  aaacttaaa  tataaccaa  agagggaca  ctctttagg  60
aaaggaaaa  accttaaat  gtgaataaa  aactacaac  acttaacca  tgtaggctt  120
aaagcagcc  tcaataaag  aagcgttca  gctcaacat  catacttac  cacactaat  180
ccacaaacc  caataaatt  ctatattac  aattgggct  atctataga  ccatagatg  240
aatactgtt  atatgagta  caagaacca  ttctcctag  acaagtgta  gacaacccg  300
ataaccatt  tcaattatc  aatcatagg  actaaccca  caataaaat  acctatccc  360
aactcgtta  cccaacaca  gcgtgcttt  aggaaagat  aacaaaaaaa  410



<210> 6629
<211> 2201
<212> DNA
<213> Homo sapiens
<308> L22009
<400> 6629

ttttttttt  cgtcttagc  acgcagaag  cgcgtgtct  gtttgtttc  acgccggac  60
gcgtaagag  cgatgatgt  gggcacgga  ggtggagag  gattcgtgg  gaaggtccg  120
ggcttgccc  ggtcttgct  ggccgatga  gtgcagagg  ttttttctg  ctgcaaaat  180
caaaatggg  ctcaaggta  tcgtttcat  tacaccaga  aaggcagac  aagtggcga  240
gcttttgtt  aacttgaat  agaagatga  gtcaaattg  ccctgaaaa  agacagaga  300
actatggga  acagatatg  tgaagtatt  aagtcaaac  acgttgaaa  ggattgggt  360
ttgaagcat  ctggtccaa  tagtcctga  acggccaat  atggctttg  acggcttag  420
ggacttccc  ttggatgta  caaggaaga  attgttcag  tcttctcag  gttggaaat  480
gtgccaaat  ggataacat  gccggtgga  ttccagggg  ggagtacgg  ggaggcctt  540
gtgcagttt  cttcacagg  aatagctga  aaggctcta  agaaacaca  ggaaagaat  600
gggcacagg  atattgaaa  ctttaagag  agtagagct  aagttagaa  tcattatga  660
ccaccacga  agcttatgg  catgcagcg  ccaggtcct  atgacagac  tggggctgg  720
agagggtat  acagcattg  cagaggagc  ggctttgag  ggatgaggc  tggtgctta  780
ggtggaggc  atggaggct  tgatgatta  aatggctat  atgatggct  tggatttgg  840
tcagataga  ttggaagag  cctcaatta  tgtttttca  gaatgtctg  tcacagata  900
ggggatggt  gctctactt  ccagagcac  acaggacac  gtgtacaca  gcggggatt  960
ccttacaga  ctactgaga  tgacattta  aattttttt  caccgctca  ccctgtgag  1020
gtacacatt  aaattggtc  tgatggcag  gtaactggt  aagcagatg  cgagttcgc  1080
actcatgaa  atgctgtgg  agctatgtc  aaagacaaa  caaatatgc  acacagata  1140
gtagaactc  tcttgaatt  tacagcagg  gcaagcggt  gtgcttacg  acacagata  1200
gtagaactc  tcttgaatt  tacagcagg  gcaagcggt  gtgcttatg  tagccaaat  1260
atgggaggc  tgggcttgt  aaaccagtc  agctacggg  gcccagcca  ccagcagct  1320
agtgggggt  acggaggcg  ctacggtgg  cagagcagc  tgagtggat  cgaccaagt  1380
ttacaggaa  actccagtg  ttttcaatc  aacattgca  aggtaacca  ggagcagtg  1440
acagcagct  ctacagtag  ggaagccgt  catctatgg  cgtgaacgg  atgggaggg  1500
tgtctagca  gtccagtat  agtggtgga  ggggaatgt  attgatcga  cctgatcac  1560
gactcttgg  caacctttt  ttttttttt  ttttcttta  gaaaacttc  gtttaacag  1620
ttctgcaat  caagcttgt  atttatgct  actctaagt  gaaatcagg  ttgttatga  1680
gacttaagg  ccagtattt  tgaatacaa  actcatcta  gatgtaaca  tgaagctga  1740
taaactata  ctgttaaac  taagttcca  cttttctca  gttagttat  ggatgtact  1800
aagcagtaa  cgtatttag  taaaagcag  tgaattatg  taaatgttg  cctttgcca  1860
gttaaattg  acactgttt  ggatgcatg  tgaaagaca  gcttttatt  tttttgtaa  1920
acaatatag  agctgtgtc  actattaaa  gtgaaacat  ttggcatgt  tgttaattc  1980
agtttcatt  aataacctg  aaggcacgt  agtttaagc  ttttttttt  ttaagttaa  2040
gggaaaaat  tgagacgca  taccaatac  taggatttt  gtcttggtg  ttgtatgaa  2100
ttctgaggc  ttgatttaa  tctttcatt  tattgtgat  tccttttag  tatattgcg  2160
taagtgaaa  ttgtcaaat  aatcctcct  ttaaaaact  c  2201



<210> 6630
<211> 449
<212> PRT
<213> Homo sapiens
<308> P31943
<400> 6630

Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
  1               5                  10                  15
Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
             20                  25                  30
Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
         35                  40                  45
Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
     50                  55                  60
Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
 65                  70                  75                  80
Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                 85                  90                  95
Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
             100                105                110
Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
         115                120                125
Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
     130                135                140
Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
 145                150                155                160
Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                 165                170                175
Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
             180                185                190
Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
         195                200                205
Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
     210                215                220
Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
 225                230                235                240
Gly Gly Tyr Asp Asp Tyr Asn Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                 245                250                255
Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
             260                265                270
Asp His Arg Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr Thr Gly 
         275                280                285
His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
     290                295                300
Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
 305                310                315                320
Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                 325                330                335
Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Ala Asn Met 
             340                345                350
Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Ala Ser 
         355                360                365
Gly Gly Ala Tyr Glu His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr 
     370                375                380
Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
 385                390                395                400
Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                 405                410                415
Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
             420                425                430
Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser Asn Ile 
         435                440                445
Ala 
     450



<210> 6631
<211> 474
<212> DNA
<213> Rattus norvegicus
<308> AI014163
<400> 6631

atgaccaag  atcacaaac  cttttattt  tggttatca  ttattttta  agaataaag  60
actcattaa  ttgtaacac  gtacattaa  ttaaaatat  acccatccc  acatcaaaa  120
ttatctaag  tgaccaaga  aaaaaaagt  tctaaaagc  tatatacat  agaagtagc  180
aaaataata  taaaggaag  aattagaaa  cagacatca  agtcagaca  ctagaagaa  240
tctccaaca  ctgctctct  atctcggca  ttgcttcgg  cttttgttc  agctttgaa  300
gctgcagag  tatataaat  cctttcaaa  cgaggaatc  tcatggttt  aagtgttgc  360
gcatcgagc  tcacagggg  tcccagctc  aatacattg  gaaggaatt  atttgtctg  420
aagtggtac  gcatccctg  tccaagagc  tctttaaac  tgtcataag  gtgc  474



<210> 6632
<211> 449
<212> PRT
<213> Rattus norvegicus
<308> P20695
<400> 6632

Met Pro Lys Asn Lys Lys Arg Asn Ala Pro His Arg Gly Gly Gly Gly 
  1               5                  10                  15
Gly Gly Gly Ser Gly Ala Ala Thr Ser Ala Ala Thr Thr Gly Gly Pro 
             20                  25                  30
His Arg Thr Val Gln Pro Phe Ser Asp Glu Asp Ala Ser Ile Glu Thr 
         35                  40                  45
Met Ser His Cys Ser Gly Tyr Ser Asp Pro Ser Ser Phe Ala Glu Asp 
     50                  55                  60
Gly Pro Glu Val Leu Asp Glu Glu Gly Thr Gln Glu Asp Leu Glu Tyr 
 65                  70                  75                  80
Lys Leu Lys Gly Leu Ile Asp Leu Thr Leu Asp Lys Ser Ala Lys Thr 
                 85                  90                  95
Arg Gln Ala Ala Leu Glu Gly Val Lys Asn Ala Leu Ser Ser Lys Val 
             100                105                110
Leu Tyr Glu Phe Val Leu Glu Arg Arg Met Thr Leu Thr Asp Ser Ile 
         115                120                125
Glu Arg Cys Leu Lys Lys Gly Lys Ser Asp Gly Gln Arg Ala Ala Ala 
     130                135                140
Ala Leu Ala Ser Val Leu Cys Ile Gln Leu Gly Pro Gly Leu Glu Ser 
 145                150                155                160
Glu Glu Ile Leu Lys Thr Leu Gly Pro Ile Leu Lys Lys Ile Ile Cys 
                 165                170                175
Asp Gly Thr Ala Ser Ile Gln Ala Arg Gln Thr Cys Ala Thr Cys Phe 
             180                185                190
Gly Val Cys Cys Phe Ile Ala Thr Asp Asp Ile Thr Glu Leu Tyr Ser 
         195                200                205
Thr Leu Glu Cys Leu Glu Gly Ile Phe Thr Lys Ser Tyr Leu Lys Glu 
     210                215                220
Lys Asp Thr Asn Val Pro Cys Ser Thr Pro Asn Thr Val Leu His Ile 
 225                230                235                240
Ser Ser Leu Leu Ala Trp Thr Leu Leu Leu Thr Ile Cys Pro Ile Ser 
                 245                250                255
Glu Val Lys Lys Lys Leu Glu Leu His Phe His Lys Leu Pro Ser Leu 
             260                265                270
Leu Ser Cys Asp Asp Val Asn Met Arg Ile Ala Ala Gly Glu Ser Leu 
         275                280                285
Ala Leu Leu Phe Glu Leu Ala Arg Gly Met Glu Ser Asp Phe Phe Tyr 
     290                295                300
Glu Asp Met Asp Ser Leu Thr Gln Met Leu Arg Ala Leu Ala Thr Asp 
 305                310                315                320
Gly Asn Lys His Arg Ala Lys Val Asp Lys Arg Lys Gln Arg Ser Val 
                 325                330                335
Phe Arg Asp Val Leu Arg Ala Val Glu Glu Arg Asp Phe Pro Thr Glu 
             340                345                350
Thr Val Lys Phe Gly Pro Glu Arg Met Tyr Ile Asp Ser Trp Val Lys 
         355                360                365
Lys His Thr Tyr Asp Thr Phe Lys Glu Ala Leu Gly Ser Gly Met Gln 
     370                375                380
Tyr His Leu Gln Thr Asn Glu Phe Leu Arg Asn Val Phe Glu Leu Gly 
 385                390                395                400
Pro Pro Val Met Leu Asp Ala Ala Thr Leu Lys Thr Met Lys Ile Pro 
                 405                410                415
Arg Phe Glu Arg His Leu Tyr Asn Ser Ala Ala Phe Lys Ala Arg Thr 
             420                425                430
Lys Ala Arg Ser Lys Cys Arg Asp Lys Arg Ala Asp Val Gly Glu Phe 
         435                440                445
Phe 
     450



<210> 6633
<211> 675
<212> DNA
<213> Homo sapiens
<308> AV733799
<400> 6633

atagtaatg  ctaactatt  tttatgcat  tccataagc  tccaagcct  ctctcgtgt  60
atgatgtaa  catgagaat  gctgctggt  aatctttgg  acttctctt  gaattggcc  120
gaggaatag  gagtgtaag  atctaactg  cagaggagc  tgtgtcaca  ggcccattg  180
tccatcatt  ccttgcaat  gagaattgg  caataactt  ggaacatgg  cagcttgag  240
acccagtga  ttatttccc  acttcttgg  agtggtggt  taatacttt  gagagcaga  300
accagtagg  gttggtaca  cagtgtttg  ctgtggttc  ttatactta  tttttgcta  360
ctatagaac  gaagtttag  gatcctcat  gagagagtt  tgtctaata  aatctttat  420
aaactgctt  gatttctca  atacccaat  catcaagct  atgaaggca  gtgatgctt  480
ataattaat  tcaaacaaa  gaatagcca  gatggtaac  actgctcat  agacttgga  540
atgtgcttt  cagttaccc  ttcactttg  cacttacag  tgttagttc  catggcttg  600
ctctcgacg  gatttgagt  gggatcagt  gtcagtcga  ccaatttgc  ttgacactg  660
ctttggtta  cctcc  675



<210> 6634
<211> 451
<212> PRT
<213> Homo sapiens
<308> O00458
<400> 6634

Met Pro Lys Asn Lys Lys Arg Asn Thr Pro His Arg Gly Ser Ser Ala 
  1               5                  10                  15
Gly Gly Gly Gly Ser Gly Ala Ala Ala Ala Thr Ala Ala Thr Ala Gly 
             20                  25                  30
Gly Gln His Arg Asn Val Gln Pro Phe Ser Asp Glu Asp Ala Ser Ile 
         35                  40                  45
Glu Thr Met Ser His Cys Ser Gly Tyr Ser Asp Pro Ser Ser Phe Ala 
     50                  55                  60
Glu Asp Gly Pro Glu Val Leu Asp Glu Glu Gly Thr Gln Glu Asp Leu 
 65                  70                  75                  80
Glu Tyr Lys Arg Lys Gly Leu Ile Asp Leu Thr Leu Asp Lys Ser Ala 
                 85                  90                  95
Lys Thr Arg Gln Ala Ala Leu Glu Gly Ile Lys Asn Ala Leu Ala Ser 
             100                105                110
Lys Met Leu Tyr Glu Phe Ile Leu Glu Arg Arg Met Thr Leu Thr Asp 
         115                120                125
Ser Ile Glu Arg Cys Leu Lys Lys Gly Lys Ser Asp Glu Gln Arg Ala 
     130                135                140
Ala Ala Ala Leu Ala Ser Val Leu Cys Ile Gln Leu Gly Pro Gly Ile 
 145                150                155                160
Glu Ser Glu Glu Ile Leu Lys Thr Leu Gly Pro Ile Leu Lys Lys Ile 
                 165                170                175
Ile Cys Asp Gly Ser Ala Ser Met Gln Ala Arg Gln Thr Cys Ala Thr 
             180                185                190
Cys Phe Gly Val Cys Cys Phe Ile Ala Thr Asp Asp Ile Thr Glu Leu 
         195                200                205
Tyr Ser Thr Leu Glu Cys Leu Glu Asn Ile Phe Thr Lys Ser Tyr Leu 
     210                215                220
Lys Glu Lys Asp Thr Thr Val Ile Cys Ser Thr Pro Asn Thr Val Leu 
 225                230                235                240
His Ile Ser Ser Leu Leu Ala Trp Thr Leu Leu Leu Thr Ile Cys Pro 
                 245                250                255
Ile Asn Glu Val Lys Lys Lys Leu Glu Met His Phe His Lys Leu Pro 
             260                265                270
Ser Leu Leu Ser Cys Asp Asp Val Asn Met Arg Ile Ala Ala Gly Glu 
         275                280                285
Ser Leu Ala Leu Leu Phe Glu Leu Ala Arg Gly Ile Glu Ser Asp Phe 
     290                295                300
Phe Tyr Glu Asp Met Glu Ser Leu Thr Gln Met Leu Arg Ala Leu Ala 
 305                310                315                320
Thr Asp Gly Asn Lys His Arg Ala Lys Val Asp Lys Arg Lys Gln Arg 
                 325                330                335
Ser Val Phe Arg Asp Val Leu Arg Ala Val Glu Glu Arg Asp Phe Pro 
             340                345                350
Thr Glu Thr Ile Lys Phe Gly Pro Glu Arg Met Tyr Ile Asp Cys Trp 
         355                360                365
Val Lys Lys His Thr Tyr Asp Thr Phe Lys Glu Val Leu Gly Ser Gly 
     370                375                380
Met Gln Tyr His Leu Gln Ser Asn Glu Phe Leu Arg Asn Val Phe Glu 
 385                390                395                400
Leu Gly Pro Pro Val Met Leu Asp Ala Ala Thr Leu Lys Thr Met Lys 
                 405                410                415
Ile Ser Arg Phe Glu Arg His Leu Tyr Asn Ser Ala Ala Phe Lys Ala 
             420                425                430
Arg Thr Lys Ala Arg Ser Lys Cys Arg Asp Lys Arg Ala Asp Val Gly 
         435                440                445
Glu Phe Phe 
     450



<210> 6635
<211> 508
<212> DNA
<213> Rattus norvegicus
<308> AI014169
<400> 6635

gccattaaa  aactttatt  tgatttttt  ttttttaca  aggatagcc  cactttggg  60
tgaaaatat  tttggttaa  tacaaaata  agtttttaa  catacaaaa  gatacacaa  120
atacaaaaa  aacaaagac  acacctcca  cagctcaca  tttctggct  cacagttct  180
gggtggagt  cttagagtg  agcttggag  tctgacaca  gacacggaa  aaagtgcta  240
ggcggagta  gttttggag  gctagaggc  acggcgaga  cagaacttt  tcctaacac  300
ggacaggaa  tgggtctgg  agcttccat  gaaacctgc  gttctcact  tgcctccat  360
actgttagg  catctcaat  taagagtgt  accagggtc  agctgtcag  agcaaccct  420
catatgagt  gtgtcagaa  cacagaagt  tgtgtgttg  gggaaagcc  ccaaaagta  480
taaccaagc  gggccttta  cctcagca  508



<210> 6636
<211> 581
<212> DNA
<213> Homo sapiens
<308> AW601963
<400> 6636

gttcaggat  ctaataaac  ctgggggta  cggcaatca  ctgcatttt  accacatac  60
cttgaataa  ccaaaatac  gagagttgc  tccctatgc  caacatcca  aggaccaaa  120
ttggaaagg  gaactgtag  tggcttata  gctggcctt  ggtgctctt  tgacctgtg  180
atagccata  ttagctcac  ggctaagag  ctgaaaaga  tctaccacc  tcaggcgtg  240
ggggaacat  aacaggagg  tgacaaaca  ggagggaag  ttctattgt  cctggtgag  300
gaattgaca  aaaaggatt  tgtgaaggt  atgagattt  catccatgc  gactttgag  360
atacatgtt  ccgaattgt  gtccccaaa  ctgccattg  ggcccgcca  acttacctt  420
ccaatggcc  gaccaaggt  ctgactcag  agttgtcat  agtcagagg  aatcatatt  480
tctcaggga  atgcgcatc  tggcgtggc  agagccttc  ggttcagaa  atcaggcct  540
ctatcctgg  tgcaacatc  ttcgagttg  atattcctt  t  581



<210> 6637
<211> 378
<212> DNA
<213> Rattus norvegicus
<308> AI029805
<400> 6637

ttttttttt  tgtctataa  gcatttaac  cccctgtac  caactcact  cttttaaag  60
aaaaaattg  aatgtaagg  tgtgtaaga  ttgttttta  actgtacag  gtctttttt  120
gtatagtta  cacactacc  aatgtgtct  tagctagcc  tgtcctggt  gtattttca  180
tagccacta  ccttgcctg  tacagtctg  gggttgtaa  ttggcatgg  aattaaagc  240
ggttcttgt  ggtgcacag  acaaattag  tatatatgg  gacagtagt  tggtttttg  300
tttcttttt  tttttttgt  tttgttttt  ttccttttg  ttttttttc  atcttcagt  360
gtctctgat  cagcttat  378



<210> 6638
<211> 214
<212> PRT
<213> Rattus norvegicus
<308> P07155
<400> 6638

Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
  1               5                  10                  15
Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
             20                  25                  30
Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
         35                  40                  45
Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys 
     50                  55                  60
Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro Pro 
 65                  70                  75                  80
Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg 
                 85                  90                  95
Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys Ile 
             100                105                110
Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu 
         115                120                125
Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu 
     130                135                140
Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
 145                150                155                160
Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys 
                 165                170                175
Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Asp Asp Glu Glu Asp 
             180                185                190
Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Glu 
         195                200                205
Glu Asp Asp Asp Asp Glu 
     210



<210> 6639
<211> 578
<212> DNA
<213> Homo sapiens
<308> AV701053
<400> 6639

cgcagcctt  tgaaaagaa  cctgcgaag  tgaaggaaa  atacgaaaa  gatattgct  60
catatcgag  taaaggaaa  cctgatgca  caaaaaaag  gagttgtca  ggctgaaaa  120
agcaagaaa  agaaggaag  ggaggaaga  gaggaagat  aagaggatg  ggaggagga  180
gaggatgaa  aagattttt  tcttgtcta  aaagcattt  acccccctg  acacaactc  240
ctcctttta  agaaaaaaa  tgaaatgta  ggctgtgta  gatttgttt  taaactgta  300
agtgtcttt  tttgtatag  taacacact  ccgaatgtg  ctttagata  ccctgtcct  360
gtggtattt  caatagcca  taaccttgc  tggtacagt  tgggggttg  aaattggca  420
ggaaattta  agcaggttc  tgttggtgc  cagcacaaa  tagttatat  tggggatgg  480
agttttttc  tcttcagtt  tctctgatg  agcttatac  aaataattg  tgttctgtt  540
actgaatac  actctgtaa  tgcaaaaaa  aaaaaaaa  578



<210> 6640
<211> 214
<212> PRT
<213> Homo sapiens
<308> P09429
<400> 6640

Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
  1               5                  10                  15
Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
             20                  25                  30
Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
         35                  40                  45
Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys 
     50                  55                  60
Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro Pro 
 65                  70                  75                  80
Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg 
                 85                  90                  95
Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys Ile 
             100                105                110
Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu 
         115                120                125
Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu 
     130                135                140
Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
 145                150                155                160
Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys 
                 165                170                175
Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu Asp 
             180                185                190
Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu Glu 
         195                200                205
Glu Asp Asp Asp Asp Glu 
     210



<210> 6641
<211> 378
<212> DNA
<213> Rattus norvegicus
<308> AI029805
<400> 6641

ttttttttt  tgtctataa  gcatttaac  cccctgtac  caactcact  cttttaaag  60
aaaaaattg  aatgtaagg  tgtgtaaga  ttgttttta  actgtacag  gtctttttt  120
gtatagtta  cacactacc  aatgtgtct  tagctagcc  tgtcctggt  gtattttca  180
tagccacta  ccttgcctg  tacagtctg  gggttgtaa  ttggcatgg  aattaaagc  240
ggttcttgt  ggtgcacag  acaaattag  tatatatgg  gacagtagt  tggtttttg  300
tttcttttt  tttttttgt  tttgttttt  ttccttttg  ttttttttc  atcttcagt  360
gtctctgat  cagcttat  378



<210> 6642
<211> 214
<212> PRT
<213> Rattus norvegicus
<308> P07155
<400> 6642

Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
  1               5                  10                  15
Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
             20                  25                  30
Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
         35                  40                  45
Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys 
     50                  55                  60
Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro Pro 
 65                  70                  75                  80
Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg 
                 85                  90                  95
Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys Ile 
             100                105                110
Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu 
         115                120                125
Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu 
     130                135                140
Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
 145                150                155                160
Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys 
                 165                170                175
Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Asp Asp Glu Glu Asp 
             180                185                190
Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Glu 
         195                200                205
Glu Asp Asp Asp Asp Glu 
     210



<210> 6643
<211> 578
<212> DNA
<213> Homo sapiens
<308> AV701053
<400> 6643

cgcagcctt  tgaaaagaa  cctgcgaag  tgaaggaaa  atacgaaaa  gatattgct  60
catatcgag  taaaggaaa  cctgatgca  caaaaaaag  gagttgtca  ggctgaaaa  120
agcaagaaa  agaaggaag  ggaggaaga  gaggaagat  aagaggatg  ggaggagga  180
gaggatgaa  aagattttt  tcttgtcta  aaagcattt  acccccctg  acacaactc  240
ctcctttta  agaaaaaaa  tgaaatgta  ggctgtgta  gatttgttt  taaactgta  300
agtgtcttt  tttgtatag  taacacact  ccgaatgtg  ctttagata  ccctgtcct  360
gtggtattt  caatagcca  taaccttgc  tggtacagt  tgggggttg  aaattggca  420
ggaaattta  agcaggttc  tgttggtgc  cagcacaaa  tagttatat  tggggatgg  480
agttttttc  tcttcagtt  tctctgatg  agcttatac  aaataattg  tgttctgtt  540
actgaatac  actctgtaa  tgcaaaaaa  aaaaaaaa  578



<210> 6644
<211> 214
<212> PRT
<213> Homo sapiens
<308> P09429
<400> 6644

Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
  1               5                  10                  15
Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
             20                  25                  30
Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
         35                  40                  45
Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys 
     50                  55                  60
Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro Pro 
 65                  70                  75                  80
Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg 
                 85                  90                  95
Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys Ile 
             100                105                110
Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu 
         115                120                125
Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu 
     130                135                140
Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
 145                150                155                160
Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys 
                 165                170                175
Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu Asp 
             180                185                190
Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu Glu 
         195                200                205
Glu Asp Asp Asp Asp Glu 
     210



<210> 6645
<211> 508
<212> DNA
<213> Rattus norvegicus
<308> AI030089
<400> 6645

ttttttttt  tttttcaga  atgagttcc  cagattaaa  tctttgcct  aggcaatgc  60
cagagtcac  tggaggatt  tgtttatgt  agtgcgcag  cccacattt  atcccaccc  120
tcaaagccc  ggtgggccc  gacataagt  ttgtgatgt  tgactgcta  gcatgccct  180
tgctcatct  catccattg  gcctgacac  gaagcttcc  gaagccggc  tggatctgc  240
aactttggg  ataaaattg  agttcttgg  acaatttcc  actgaactg  caggcagga  300
tctcgatgt  agtgcgatg  aacggtttt  gttttgttc  cagtagcta  tagtgctac  360
tgtttacag  gtgttctag  tttaatttc  aagtaagct  ttctgacac  gagaggcat  420
tgcaacaac  tgactctta  cgctgttgt  tataagctc  tgaatatat  tgattcttg  480
taacatcat  aacatcagc  tcgtgccg  508



<210> 6646
<211> 704
<212> PRT
<213> Rattus norvegicus
<308> P41777
<400> 6646

Met Ala Asp Thr Gly Leu Arg Arg Val Val Pro Ser Asp Leu Tyr Pro 
  1               5                  10                  15
Leu Val Leu Gly Phe Leu Arg Asp Asn Gln Leu Ser Glu Val Ala Ser 
             20                  25                  30
Lys Phe Ala Lys Ala Thr Gly Ala Thr Gln Gln Asp Ala Asn Ala Ser 
         35                  40                  45
Ser Leu Leu Asp Ile Tyr Ser Phe Trp Leu Lys Ser Thr Lys Ala Pro 
     50                  55                  60
Lys Val Lys Leu Gln Ser Asn Gly Pro Val Ala Lys Lys Ala Lys Lys 
 65                  70                  75                  80
Glu Thr Ser Ser Ser Asp Ser Ser Glu Asp Ser Ser Glu Glu Glu Asp 
                 85                  90                  95
Lys Ala Gln Val Pro Thr Gln Lys Ala Ala Ala Pro Ala Lys Arg Ala 
             100                105                110
Ser Leu Pro Gln His Ala Gly Lys Ala Ala Ala Lys Ala Ser Glu Ser 
         115                120                125
Ser Ser Ser Glu Glu Ser Ser Glu Glu Glu Glu Glu Lys Asp Lys Lys 
     130                135                140
Lys Lys Pro Val Gln Gln Lys Ala Val Lys Pro Gln Ala Lys Ala Val 
 145                150                155                160
Arg Pro Pro Pro Lys Lys Ala Glu Ser Ser Glu Ser Glu Ser Asp Ser 
                 165                170                175
Ser Ser Glu Asp Glu Ala Pro Gln Thr Gln Lys Pro Lys Ala Ala Ala 
             180                185                190
Thr Ala Ala Lys Ala Pro Thr Lys Ala Gln Thr Lys Ala Pro Ala Lys 
         195                200                205
Pro Gly Pro Pro Ala Lys Ala Gln Pro Lys Ala Ala Asn Gly Lys Ala 
     210                215                220
Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Asp Ser Glu 
 225                230                235                240
Glu Glu Lys Lys Ala Ala Ala Pro Leu Lys Lys Thr Ala Pro Lys Lys 
                 245                250                255
Gln Val Val Ala Lys Ala Pro Val Lys Val Thr Ala Ala Pro Thr Gln 
             260                265                270
Lys Ser Ser Ser Ser Glu Asp Ser Ser Ser Glu Glu Glu Glu Glu Gln 
         275                280                285
Lys Lys Pro Met Lys Lys Lys Ala Gly Pro Tyr Ser Ser Val Pro Pro 
     290                295                300
Pro Ser Val Ser Leu Ser Lys Lys Ser Val Gly Ala Gln Ser Pro Lys 
 305                310                315                320
Lys Ala Ala Ala Gln Thr Gln Pro Ala Asp Ser Ser Ala Asp Ser Ser 
                 325                330                335
Glu Glu Ser Asp Ser Ser Ser Glu Glu Glu Lys Lys Thr Pro Ala Lys 
             340                345                350
Thr Val Val Ser Lys Thr Pro Ala Lys Pro Ala Pro Val Lys Lys Lys 
         355                360                365
Ala Glu Ser Ser Ser Asp Ser Ser Asp Ser Asp Ser Ser Glu Asp Glu 
     370                375                380
Ala Pro Ala Lys Pro Val Ser Ala Thr Lys Ser Pro Leu Ser Lys Pro 
 385                390                395                400
Ala Val Thr Pro Lys Pro Pro Ala Ala Lys Ala Val Ala Thr Pro Lys 
                 405                410                415
Gln Pro Ala Gly Ser Gly Gln Lys Pro Gln Ser Arg Lys Ala Asp Ser 
             420                425                430
Ser Ser Ser Glu Glu Glu Ser Ser Ser Ser Glu Glu Glu Ala Thr Lys 
         435                440                445
Lys Ser Val Thr Thr Pro Lys Ala Arg Val Thr Ala Lys Ala Ala Pro 
     450                455                460
Ser Leu Pro Ala Lys Gln Ala Pro Arg Ala Gly Gly Asp Ser Ser Ser 
 465                470                475                480
Asp Ser Glu Ser Ser Ser Ser Glu Glu Glu Lys Lys Thr Pro Pro Lys 
                 485                490                495
Pro Pro Ala Lys Lys Lys Ala Ala Gly Ala Ala Val Pro Lys Pro Thr 
             500                505                510
Pro Val Lys Lys Ala Ala Ala Glu Ser Ser Ser Ser Ser Ser Ser Ser 
         515                520                525
Glu Asp Ser Ser Glu Glu Glu Lys Lys Lys Pro Lys Ser Lys Ala Thr 
     530                535                540
Pro Lys Pro Gln Ala Gly Lys Ala Asn Gly Val Pro Ala Ser Gln Asn 
 545                550                555                560
Gly Lys Ala Gly Lys Glu Ser Glu Glu Glu Glu Glu Asp Thr Glu Gln 
                 565                570                575
Asn Lys Lys Ala Ala Gly Thr Lys Pro Gly Ser Gly Lys Lys Arg Lys 
             580                585                590
His Asn Glu Thr Ala Asp Glu Ala Ala Thr Pro Gln Ser Lys Lys Val 
         595                600                605
Lys Leu Gln Thr Pro Asn Thr Phe Pro Lys Arg Lys Lys Gly Glu Lys 
     610                615                620
Arg Ala Ser Ser Pro Phe Arg Arg Val Arg Glu Glu Glu Ile Glu Val 
 625                630                635                640
Asp Ser Arg Val Ala Asp Asn Ser Phe Asp Ala Lys Arg Gly Ala Ala 
                 645                650                655
Gly Asp Trp Gly Glu Arg Ala Asn Gln Val Leu Lys Phe Thr Lys Gly 
             660                665                670
Lys Ser Phe Arg His Glu Lys Thr Lys Lys Lys Arg Gly Ser Tyr Arg 
         675                680                685
Gly Gly Ser Ile Ser Val Gln Val Asn Ser Val Lys Phe Asp Ser Glu 
     690                695                700



<210> 6647
<211> 505
<212> DNA
<213> Rattus norvegicus
<308> AI030175
<400> 6647

ttttttttt  tttttctcg  cttatgagt  tattattcc  accattcaa  aagaaggtt  60
tgcattaat  gcttcccct  ctggtccat  tagccctta  atgctgaga  agtgggcta  120
gggcataga  caatcacat  taggggttc  ggtcattgg  gtcacactt  atcataact  180
tcagcccca  tcccttttt  gctgtttca  aggcttcta  agccttctc  agggggaac  240
tatgggtca  taagggctt  acattcaaa  tcttcgatg  aagcatgga  actgccatc  300
gccacgtgt  gcagtatcg  aacacgcct  tgatgtcca  ctcccgcac  gctgcgtgc  360
ctaggggta  attgatcat  tcggggccc  ttcccacaa  caccaaggt  ccgccagag  420
gagtggcat  natgcccgt  tggacagag  actccgctc  cgtgcattc  atggtgacc  480
ctggcttgc  ccccagcac  ctttc  505



<210> 6648
<211> 399
<212> PRT
<213> Rattus norvegicus
<308> P27867
<400> 6648

Met Val Phe Ser Ser Arg Val Phe Phe Phe Ser Arg Val Pro Leu Leu 
  1               5                  10                  15
Gln Thr Leu Gly Gly Leu Thr Ser Arg Asn Thr Ser Ser Pro Pro Asp 
             20                  25                  30
Pro Ala Asp Thr Ser Lys Gln Glu Ser Asp Met Ala Ala Pro Ala Lys 
         35                  40                  45
Gly Glu Asn Leu Ser Leu Val Val His Gly Pro Gly Asp Ile Arg Leu 
     50                  55                  60
Glu Asn Tyr Pro Ile Pro Glu Leu Gly Pro Asn Asp Val Leu Leu Lys 
 65                  70                  75                  80
Met His Ser Val Gly Ile Cys Gly Ser Asp Val His Tyr Trp Glu His 
                 85                  90                  95
Gly Arg Ile Gly Asp Phe Val Val Lys Lys Pro Met Val Leu Gly His 
             100                105                110
Glu Ala Ala Gly Thr Val Thr Lys Val Gly Pro Met Val Lys His Leu 
         115                120                125
Lys Pro Gly Asp Arg Val Ala Ile Glu Pro Gly Val Pro Arg Glu Ile 
     130                135                140
Asp Glu Phe Cys Lys Ile Gly Arg Tyr Asn Leu Thr Pro Ser Ile Phe 
 145                150                155                160
Phe Cys Ala Thr Pro Pro Asp Asp Gly Asn Leu Cys Arg Phe Tyr Lys 
                 165                170                175
His Ser Ala Asp Phe Cys Tyr Lys Leu Pro Asp Ser Val Thr Phe Glu 
             180                185                190
Glu Gly Ala Leu Ile Glu Pro Leu Ser Val Gly Ile Tyr Ala Cys Arg 
         195                200                205
Arg Gly Ser Val Ser Leu Gly Asn Lys Val Leu Val Cys Gly Ala Gly 
     210                215                220
Pro Ile Gly Ile Val Thr Leu Leu Val Ala Lys Ala Met Gly Ala Ser 
 225                230                235                240
Gln Val Val Val Ile Asp Leu Ser Ala Ser Arg Leu Ala Lys Ala Lys 
                 245                250                255
Glu Val Gly Ala Asp Phe Thr Ile Gln Val Ala Lys Glu Thr Pro His 
             260                265                270
Asp Ile Ala Lys Lys Val Glu Ser Val Leu Gly Ser Lys Pro Glu Val 
         275                280                285
Thr Ile Glu Cys Thr Gly Ala Glu Ser Ser Val Gln Asp Gly Ile Tyr 
     290                295                300
Ala Thr His Ser Gly Gly Thr Leu Val Val Val Gly Met Gly Pro Glu 
 305                310                315                320
Met Ile Asn Leu Pro Leu Val His Ala Ala Val Arg Glu Val Asp Ile 
                 325                330                335
Lys Gly Val Phe Arg Tyr Cys Asn Thr Trp Pro Met Ala Val Ser Met 
             340                345                350
Leu Ala Ser Lys Thr Leu Asn Val Lys Pro Leu Val Thr His Arg Phe 
         355                360                365
Pro Leu Glu Lys Ala Val Glu Ala Phe Glu Thr Ala Lys Lys Gly Leu 
     370                375                380
Gly Leu Lys Val Met Ile Lys Cys Asp Pro Asn Asp Gln Asn Pro 
 385                390                395



<210> 6649
<211> 2519
<212> DNA
<213> Homo sapiens
<308> L29008
<400> 6649

agtcccgcc  ctgcgtgcg  cgcttctcc  aggccccac  ttccatcca  tgccctgga  60
cctcggctg  gtagcgcca  cagagcgac  aaacgtccc  cgccttcca  gccgcactc  120
agagccaaa  gagctccat  gcggcggcg  ccaagccca  caacctttc  ctggtggtg  180
acggaccgg  ggacttgcg  ctggagaac  atcctatcc  tgaaccagg  ccaaatgag  240
tcttgctga  gatgcattc  gttggaatc  gtggctcag  tgtccacta  tgggagtat  300
gtcgaattg  gaattttat  gtgaaaaag  ccatggtgc  gggacatga  gcttcggga  360
cagtcgaaa  agtgggatc  tcggtaaag  acctaaaac  aggtgatcg  gttgccatc  420
agcctggtg  tccccgaga  aatgatgaa  tctgcaaga  gggccgata  aatctgtca  480
cttccatct  cttctgtgc  acgcccccc  atgacggga  cctctgccg  ttctataag  540
acaatgcag  cttttgtta  aagcttcct  acaatgtca  ctttgagga  ggcgccctg  600
tcgagccac  ttctgtggg  atccatgcc  gcaggagag  cggagttac  ctgggacac  660
aggtccttg  gtgtggagc  gggccaatc  ggatggtca  tttgctcgt  gccaaagca  720
tgggagcag  tcaagtagt  gtgactgat  tgtctgcta  ccgattgtc  aaagccaag  780
agattgggg  tgatttagt  ctccagatc  ccaaggaga  ccctcagga  atcgccagg  840
aagtagaag  tctgctggg  tgcaagccg  aagtcacca  cgagtgcac  ggggcagag  900
cctccatcc  ggcgggcat  tacgccact  gctctggtg  gaccctcgt  cttgtgggg  960
tgggctctg  gatgaccac  gtaccccta  tgcatgcag  catccggga  gtggatatc  1020
agggcgtgt  tcgatactg  aacacgtgg  cagtggcga  ttcgatgct  gcgtccaag  1080
ctgtgaatg  aaaacccct  gtcacccat  ggtttcctc  ggagaaagc  ctggaggcc  1140
ttgaaacat  taaaaaggg  ttggggttg  aaatcatgc  caagtgtga  cccagtgac  1200
agaatccct  atgttaatg  gctctgctc  tccccacag  ctcgggatc  cagggcaca  1260
tggctggac  ggggtgggc  ctgatgcag  actttctct  ttgaatgtt  agaataact  1320
atacaattc  ttgtgaaca  aagtcctta  gcagaggaa  tggtgtgcc  taaagatac  1380
atctgggat  gtttggggg  acttgtagc  agaatgccc  gttcatgct  agcaaagtt  1440
agcaagtag  gcagagttt  gcaggcagg  gccaggaac  ccccttctt  ctggagtgc  1500
ttcattgag  aaggaaatc  ggcccttgg  tttcctggt  ccactgcta  tgacccaga  1560
gggaatgag  gctgagtta  gaaaagata  cttcatgaa  acttaactg  cccagaagc  1620
gattttcat  aaaatctgc  actcagggt  tgggatgaa  gcttgtcag  acttccagt  1680
tagaacgca  tgtttctag  gacatattg  ctgtttgtt  tgatgataa  aggagaata  1740
gaaaaggca  cactttcct  gatccagga  aatttttaa  ccaatcaaa  gaaaaaaac  1800
aacaaacaa  aaaggaaat  tcatgtgag  ttaaaccag  ttgcattcc  ctaatgtgg  1860
aaaagtaag  ggactactc  gcactgttt  aagattgcc  cttctacag  ttctgagaa  1920
tgtgttatt  cacttgcca  gtgaaggac  ccctcccca  catgcccca  cccacccct  1980
agcatggtc  cttgtcacc  ggcaaccag  aaactgcta  ttgtggacc  caccagaga  2040
caggagggt  tggttagct  acaggactt  ccccacccc  gaagattag  atcccatac  2100
agactcata  tcaactcaa  taggctcat  ctcaattga  ggttattag  caattccat  2160
tctttctgg  tattataaa  agaaaatct  tcctcttct  attaccagt  aaggctctt  2220
gtatctttc  gttggaatg  tttctatga  cttgtctta  tttaatggt  ggttttttt  2280
ctggtaaga  ttagaccta  atcgcatca  gccaacttg  gactttgag  ctattcatc  2340
agaatgagg  tatagtagc  atgacatag  ttgagctat  gcctttaat  ccttacttt  2400
gctatgggt  gagggtgag  ttgaagagg  tctgatttt  ttgtaacct  ggaaagcca  2460
gaccttgtg  ccgattctt  cagattgct  tgggtaata  atattggtg  tggtatctg  2519



<210> 6650
<211> 356
<212> PRT
<213> Homo sapiens
<308> Q00796
<400> 6650

Ala Ala Ala Ala Lys Pro Asn Asn Leu Ser Leu Val Val His Gly Pro 
  1               5                  10                  15
Gly Asp Leu Arg Leu Glu Asn Tyr Pro Ile Pro Glu Pro Gly Pro Asn 
             20                  25                  30
Glu Val Leu Leu Arg Met His Ser Val Gly Ile Cys Gly Ser Asp Val 
         35                  40                  45
His Tyr Trp Glu Tyr Gly Arg Ile Gly Asn Phe Ile Val Lys Lys Pro 
     50                  55                  60
Met Val Leu Gly His Glu Ala Ser Gly Thr Val Glu Lys Val Gly Ser 
 65                  70                  75                  80
Ser Val Lys His Leu Lys Pro Gly Asp Arg Val Ala Ile Glu Pro Gly 
                 85                  90                  95
Ala Pro Arg Glu Asn Asp Glu Phe Cys Lys Met Gly Arg Tyr Asn Leu 
             100                105                110
Ser Pro Ser Ile Phe Phe Cys Ala Thr Pro Pro Asp Asp Gly Asn Leu 
         115                120                125
Cys Arg Phe Tyr Lys His Asn Ala Ala Phe Cys Tyr Lys Leu Pro Asp 
     130                135                140
Asn Val Thr Phe Glu Glu Gly Ala Leu Ile Glu Pro Leu Ser Val Gly 
 145                150                155                160
Ile His Ala Cys Arg Arg Gly Gly Val Thr Leu Gly His Lys Val Leu 
                 165                170                175
Val Cys Gly Ala Gly Pro Ile Gly Met Val Thr Leu Leu Val Ala Lys 
             180                185                190
Ala Met Gly Ala Ala Gln Val Val Val Thr Asp Leu Ser Ala Thr Arg 
         195                200                205
Leu Ser Lys Ala Lys Glu Ile Gly Ala Asp Leu Val Leu Gln Ile Ser 
     210                215                220
Lys Glu Ser Pro Gln Glu Ile Ala Arg Lys Val Glu Gly Leu Leu Gly 
 225                230                235                240
Cys Lys Pro Glu Val Thr Ile Glu Cys Thr Gly Ala Glu Ala Ser Ile 
                 245                250                255
Gln Ala Gly Ile Tyr Ala Thr Arg Ser Gly Gly Thr Leu Val Leu Val 
             260                265                270
Gly Leu Gly Ser Glu Met Thr Thr Val Pro Leu Leu His Ala Ala Ile 
         275                280                285
Arg Glu Val Asp Ile Lys Gly Val Phe Arg Tyr Cys Asn Thr Trp Pro 
     290                295                300
Val Ala Ile Ser Met Leu Ala Ser Lys Ser Val Asn Val Lys Pro Leu 
 305                310                315                320
Val Thr His Arg Phe Pro Leu Glu Lys Ala Leu Glu Ala Phe Glu Thr 
                 325                330                335
Phe Lys Lys Gly Leu Gly Leu Lys Ile Met Leu Lys Cys Asp Pro Ser 
             340                345                350
Asp Gln Asn Pro 
         355



<210> 6651
<211> 505
<212> DNA
<213> Rattus norvegicus
<308> AI030175
<400> 6651

ttttttttt  tttttctcg  cttatgagt  tattattcc  accattcaa  aagaaggtt  60
tgcattaat  gcttcccct  ctggtccat  tagccctta  atgctgaga  agtgggcta  120
gggcataga  caatcacat  taggggttc  ggtcattgg  gtcacactt  atcataact  180
tcagcccca  tcccttttt  gctgtttca  aggcttcta  agccttctc  agggggaac  240
tatgggtca  taagggctt  acattcaaa  tcttcgatg  aagcatgga  actgccatc  300
gccacgtgt  gcagtatcg  aacacgcct  tgatgtcca  ctcccgcac  gctgcgtgc  360
ctaggggta  attgatcat  tcggggccc  ttcccacaa  caccaaggt  ccgccagag  420
gagtggcat  natgcccgt  tggacagag  actccgctc  cgtgcattc  atggtgacc  480
ctggcttgc  ccccagcac  ctttc  505



<210> 6652
<211> 399
<212> PRT
<213> Rattus norvegicus
<308> P27867
<400> 6652

Met Val Phe Ser Ser Arg Val Phe Phe Phe Ser Arg Val Pro Leu Leu 
  1               5                  10                  15
Gln Thr Leu Gly Gly Leu Thr Ser Arg Asn Thr Ser Ser Pro Pro Asp 
             20                  25                  30
Pro Ala Asp Thr Ser Lys Gln Glu Ser Asp Met Ala Ala Pro Ala Lys 
         35                  40                  45
Gly Glu Asn Leu Ser Leu Val Val His Gly Pro Gly Asp Ile Arg Leu 
     50                  55                  60
Glu Asn Tyr Pro Ile Pro Glu Leu Gly Pro Asn Asp Val Leu Leu Lys 
 65                  70                  75                  80
Met His Ser Val Gly Ile Cys Gly Ser Asp Val His Tyr Trp Glu His 
                 85                  90                  95
Gly Arg Ile Gly Asp Phe Val Val Lys Lys Pro Met Val Leu Gly His 
             100                105                110
Glu Ala Ala Gly Thr Val Thr Lys Val Gly Pro Met Val Lys His Leu 
         115                120                125
Lys Pro Gly Asp Arg Val Ala Ile Glu Pro Gly Val Pro Arg Glu Ile 
     130                135                140
Asp Glu Phe Cys Lys Ile Gly Arg Tyr Asn Leu Thr Pro Ser Ile Phe 
 145                150                155                160
Phe Cys Ala Thr Pro Pro Asp Asp Gly Asn Leu Cys Arg Phe Tyr Lys 
                 165                170                175
His Ser Ala Asp Phe Cys Tyr Lys Leu Pro Asp Ser Val Thr Phe Glu 
             180                185                190
Glu Gly Ala Leu Ile Glu Pro Leu Ser Val Gly Ile Tyr Ala Cys Arg 
         195                200                205
Arg Gly Ser Val Ser Leu Gly Asn Lys Val Leu Val Cys Gly Ala Gly 
     210                215                220
Pro Ile Gly Ile Val Thr Leu Leu Val Ala Lys Ala Met Gly Ala Ser 
 225                230                235                240
Gln Val Val Val Ile Asp Leu Ser Ala Ser Arg Leu Ala Lys Ala Lys 
                 245                250                255
Glu Val Gly Ala Asp Phe Thr Ile Gln Val Ala Lys Glu Thr Pro His 
             260                265                270
Asp Ile Ala Lys Lys Val Glu Ser Val Leu Gly Ser Lys Pro Glu Val 
         275                280                285
Thr Ile Glu Cys Thr Gly Ala Glu Ser Ser Val Gln Asp Gly Ile Tyr 
     290                295                300
Ala Thr His Ser Gly Gly Thr Leu Val Val Val Gly Met Gly Pro Glu 
 305                310                315                320
Met Ile Asn Leu Pro Leu Val His Ala Ala Val Arg Glu Val Asp Ile 
                 325                330                335
Lys Gly Val Phe Arg Tyr Cys Asn Thr Trp Pro Met Ala Val Ser Met 
             340                345                350
Leu Ala Ser Lys Thr Leu Asn Val Lys Pro Leu Val Thr His Arg Phe 
         355                360                365
Pro Leu Glu Lys Ala Val Glu Ala Phe Glu Thr Ala Lys Lys Gly Leu 
     370                375                380
Gly Leu Lys Val Met Ile Lys Cys Asp Pro Asn Asp Gln Asn Pro 
 385                390                395



<210> 6653
<211> 2519
<212> DNA
<213> Homo sapiens
<308> L29008
<400> 6653

agtcccgcc  ctgcgtgcg  cgcttctcc  aggccccac  ttccatcca  tgccctgga  60
cctcggctg  gtagcgcca  cagagcgac  aaacgtccc  cgccttcca  gccgcactc  120
agagccaaa  gagctccat  gcggcggcg  ccaagccca  caacctttc  ctggtggtg  180
acggaccgg  ggacttgcg  ctggagaac  atcctatcc  tgaaccagg  ccaaatgag  240
tcttgctga  gatgcattc  gttggaatc  gtggctcag  tgtccacta  tgggagtat  300
gtcgaattg  gaattttat  gtgaaaaag  ccatggtgc  gggacatga  gcttcggga  360
cagtcgaaa  agtgggatc  tcggtaaag  acctaaaac  aggtgatcg  gttgccatc  420
agcctggtg  tccccgaga  aatgatgaa  tctgcaaga  gggccgata  aatctgtca  480
cttccatct  cttctgtgc  acgcccccc  atgacggga  cctctgccg  ttctataag  540
acaatgcag  cttttgtta  aagcttcct  acaatgtca  ctttgagga  ggcgccctg  600
tcgagccac  ttctgtggg  atccatgcc  gcaggagag  cggagttac  ctgggacac  660
aggtccttg  gtgtggagc  gggccaatc  ggatggtca  tttgctcgt  gccaaagca  720
tgggagcag  tcaagtagt  gtgactgat  tgtctgcta  ccgattgtc  aaagccaag  780
agattgggg  tgatttagt  ctccagatc  ccaaggaga  ccctcagga  atcgccagg  840
aagtagaag  tctgctggg  tgcaagccg  aagtcacca  cgagtgcac  ggggcagag  900
cctccatcc  ggcgggcat  tacgccact  gctctggtg  gaccctcgt  cttgtgggg  960
tgggctctg  gatgaccac  gtaccccta  tgcatgcag  catccggga  gtggatatc  1020
agggcgtgt  tcgatactg  aacacgtgg  cagtggcga  ttcgatgct  gcgtccaag  1080
ctgtgaatg  aaaacccct  gtcacccat  ggtttcctc  ggagaaagc  ctggaggcc  1140
ttgaaacat  taaaaaggg  ttggggttg  aaatcatgc  caagtgtga  cccagtgac  1200
agaatccct  atgttaatg  gctctgctc  tccccacag  ctcgggatc  cagggcaca  1260
tggctggac  ggggtgggc  ctgatgcag  actttctct  ttgaatgtt  agaataact  1320
atacaattc  ttgtgaaca  aagtcctta  gcagaggaa  tggtgtgcc  taaagatac  1380
atctgggat  gtttggggg  acttgtagc  agaatgccc  gttcatgct  agcaaagtt  1440
agcaagtag  gcagagttt  gcaggcagg  gccaggaac  ccccttctt  ctggagtgc  1500
ttcattgag  aaggaaatc  ggcccttgg  tttcctggt  ccactgcta  tgacccaga  1560
gggaatgag  gctgagtta  gaaaagata  cttcatgaa  acttaactg  cccagaagc  1620
gattttcat  aaaatctgc  actcagggt  tgggatgaa  gcttgtcag  acttccagt  1680
tagaacgca  tgtttctag  gacatattg  ctgtttgtt  tgatgataa  aggagaata  1740
gaaaaggca  cactttcct  gatccagga  aatttttaa  ccaatcaaa  gaaaaaaac  1800
aacaaacaa  aaaggaaat  tcatgtgag  ttaaaccag  ttgcattcc  ctaatgtgg  1860
aaaagtaag  ggactactc  gcactgttt  aagattgcc  cttctacag  ttctgagaa  1920
tgtgttatt  cacttgcca  gtgaaggac  ccctcccca  catgcccca  cccacccct  1980
agcatggtc  cttgtcacc  ggcaaccag  aaactgcta  ttgtggacc  caccagaga  2040
caggagggt  tggttagct  acaggactt  ccccacccc  gaagattag  atcccatac  2100
agactcata  tcaactcaa  taggctcat  ctcaattga  ggttattag  caattccat  2160
tctttctgg  tattataaa  agaaaatct  tcctcttct  attaccagt  aaggctctt  2220
gtatctttc  gttggaatg  tttctatga  cttgtctta  tttaatggt  ggttttttt  2280
ctggtaaga  ttagaccta  atcgcatca  gccaacttg  gactttgag  ctattcatc  2340
agaatgagg  tatagtagc  atgacatag  ttgagctat  gcctttaat  ccttacttt  2400
gctatgggt  gagggtgag  ttgaagagg  tctgatttt  ttgtaacct  ggaaagcca  2460
gaccttgtg  ccgattctt  cagattgct  tgggtaata  atattggtg  tggtatctg  2519



<210> 6654
<211> 356
<212> PRT
<213> Homo sapiens
<308> Q00796
<400> 6654

Ala Ala Ala Ala Lys Pro Asn Asn Leu Ser Leu Val Val His Gly Pro 
  1               5                  10                  15
Gly Asp Leu Arg Leu Glu Asn Tyr Pro Ile Pro Glu Pro Gly Pro Asn 
             20                  25                  30
Glu Val Leu Leu Arg Met His Ser Val Gly Ile Cys Gly Ser Asp Val 
         35                  40                  45
His Tyr Trp Glu Tyr Gly Arg Ile Gly Asn Phe Ile Val Lys Lys Pro 
     50                  55                  60
Met Val Leu Gly His Glu Ala Ser Gly Thr Val Glu Lys Val Gly Ser 
 65                  70                  75                  80
Ser Val Lys His Leu Lys Pro Gly Asp Arg Val Ala Ile Glu Pro Gly 
                 85                  90                  95
Ala Pro Arg Glu Asn Asp Glu Phe Cys Lys Met Gly Arg Tyr Asn Leu 
             100                105                110
Ser Pro Ser Ile Phe Phe Cys Ala Thr Pro Pro Asp Asp Gly Asn Leu 
         115                120                125
Cys Arg Phe Tyr Lys His Asn Ala Ala Phe Cys Tyr Lys Leu Pro Asp 
     130                135                140
Asn Val Thr Phe Glu Glu Gly Ala Leu Ile Glu Pro Leu Ser Val Gly 
 145                150                155                160
Ile His Ala Cys Arg Arg Gly Gly Val Thr Leu Gly His Lys Val Leu 
                 165                170                175
Val Cys Gly Ala Gly Pro Ile Gly Met Val Thr Leu Leu Val Ala Lys 
             180                185                190
Ala Met Gly Ala Ala Gln Val Val Val Thr Asp Leu Ser Ala Thr Arg 
         195                200                205
Leu Ser Lys Ala Lys Glu Ile Gly Ala Asp Leu Val Leu Gln Ile Ser 
     210                215                220
Lys Glu Ser Pro Gln Glu Ile Ala Arg Lys Val Glu Gly Leu Leu Gly 
 225                230                235                240
Cys Lys Pro Glu Val Thr Ile Glu Cys Thr Gly Ala Glu Ala Ser Ile 
                 245                250                255
Gln Ala Gly Ile Tyr Ala Thr Arg Ser Gly Gly Thr Leu Val Leu Val 
             260                265                270
Gly Leu Gly Ser Glu Met Thr Thr Val Pro Leu Leu His Ala Ala Ile 
         275                280                285
Arg Glu Val Asp Ile Lys Gly Val Phe Arg Tyr Cys Asn Thr Trp Pro 
     290                295                300
Val Ala Ile Ser Met Leu Ala Ser Lys Ser Val Asn Val Lys Pro Leu 
 305                310                315                320
Val Thr His Arg Phe Pro Leu Glu Lys Ala Leu Glu Ala Phe Glu Thr 
                 325                330                335
Phe Lys Lys Gly Leu Gly Leu Lys Ile Met Leu Lys Cys Asp Pro Ser 
             340                345                350
Asp Gln Asn Pro 
         355



<210> 6655
<211> 367
<212> DNA
<213> Rattus norvegicus
<308> AI030286
<400> 6655

ttttttttt  tttttgtct  ttttctgaa  gagggacag  ttattatca  ttcacaatt  60
aagcagcat  caatttatt  tttttttta  ctttttgtt  tattcctgg  aacggcaac  120
aaccacaac  ttatcgagg  atgttatgc  gacttttaa  gttgtgcgc  aatgactgt  180
tcattctgg  catggatat  tccaataaa  agattgtag  accactgta  tgtataaac  240
tcatttata  atgcagttc  taaaattat  tttttctta  ctgaataat  taccctgtt  300
tgtctatat  caaatagat  atttttgtc  caatataat  tatacaaca  aaatccctc  360
tgccgaa  367



<210> 6656
<211> 249
<212> PRT
<213> Rattus norvegicus
<308> P23363
<400> 6656

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
  1               5                  10                  15
Lys Ala Ala Pro Met Lys Glu Ala Asn Val His Gly Gln Gly Asn Leu 
             20                  25                  30
Ala Tyr Pro Ala Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
         35                  40                  45
Pro Arg Ala Gly Ser Arg Gly Leu Thr Thr Thr Ser Leu Ala Asp Thr 
     50                  55                  60
Phe Glu His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg 
 65                  70                  75                  80
Pro Asn Glu Glu Asn His Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val 
                 85                  90                  95
Met Leu Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu 
             100                105                110
Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val 
         115                120                125
Arg Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp 
     130                135                140
Ser Ile Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp 
 145                150                155                160
Met Ser Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys 
                 165                170                175
Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly 
             180                185                190
Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser 
         195                200                205
Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser 
     210                215                220
Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val 
 225                230                235                240
Cys Thr Leu Thr Ile Lys Arg Gly Arg 
                 245



<210> 6657
<211> 1353
<212> DNA
<213> Homo sapiens
<308> X60201
<400> 6657

gaattcggg  ctgccgccg  cgcgcccgg  cgcacccgc  cgctcgctg  cccgcgcac  60
ccgtagcgc  tcgggctcc  gggccggac  gaggagcca  cccggtgcg  ccctccacc  120
cctgctcgg  gggctttaa  gagacaccc  ccgctgctg  ggggccggc  gggagcagc  180
ccgcgacgg  gaccggggc  gggcgctgg  gccagaatc  gaaccacga  gtgactccg  240
cgccgggga  ccgtgaggt  tgtgtggac  ccgagttcc  ccaggtgag  agagtgatg  300
ccatccttt  ccttactat  gttatttca  actttggtt  catgaaggc  gcccccatg  360
aagaagcaa  catccgagg  caaggtggc  tggcctacc  aggtgtgcg  acccatggg  420
ctctggaga  cgtgaatgg  cccaaggca  gttcaagag  cttgacatc  ttggctgac  480
ctttcgaac  cgtgataga  gagctgttg  atgaggacc  gaaagttcg  cccaatgaa  540
aaaacaata  ggacgcaga  ttgtacacg  ccagggtga  gctcagtag  caagtgcct  600
tggagcctc  tcttctctt  ctgctggag  aatacaaaa  ttacctaga  gctgcaaac  660
tgtccatga  ggtccggcg  cactctgac  ctgcccgcc  aggggagct  agcgtgtgt  720
acagtatta  tgagtgggt  acggcggca  acaaaaaga  tgcagtgga  atgtcgggc  780
ggacggtca  agtccttga  aaggtccct  tatcaaaag  ccaactgaa  caatacttc  840
acgagacca  gtgcaatcc  atgggttac  caaaagaag  ctgcagggg  atagacaaa  900
ggcattgga  ctcccagtg  cgaactacc  agtcgtacg  gcgggccct  accatggat  960
gcaaaaaga  aattggctg  cgattcata  ggatagaca  ttcttgtgt  tgtacattg  1020
ccattaaaa  gggaagata  tggatttat  ttgtataga  tagattata  tgagacaaa  1080
attatctat  tgtatatat  cataacagg  taaattatt  agttaagaa  aaaataatt  1140
tatgaactg  atgtataaa  gaagtttat  cagtacagt  gttctacaa  ctatttatt  1200
gacatgtcc  tgaccagaa  ggaaacagt  atttgcgca  aacttaaaa  gtctgcatt  1260
cattccttg  taatgttgt  gtttgttgc  gttgccaag  actgaaaac  taaaaagtt  1320
aaaaaaata  taaattgca  gctgcccga  ttc  1353



<210> 6658
<211> 247
<212> PRT
<213> Homo sapiens
<308> P23560
<400> 6658

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
  1               5                  10                  15
Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
             20                  25                  30
Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
         35                  40                  45
Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
     50                  55                  60
His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
 65                  70                  75                  80
Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                 85                  90                  95
Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
             100                105                110
Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
         115                120                125
His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
     130                135                140
Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
 145                150                155                160
Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                 165                170                175
Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
             180                185                190
Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
         195                200                205
Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
     210                215                220
Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
 225                230                235                240
Leu Thr Ile Lys Arg Gly Arg 
                 245



<210> 6659
<211> 531
<212> DNA
<213> Rattus norvegicus
<308> AI043631
<400> 6659

ttttttttt  tttttttaa  atctacaca  agttttatt  caatcatac  aggttacat  60
aggtcaaat  caacaaata  tatgatgca  ttttacatt  attaaacta  agtccaaag  120
acaaattta  acactctaa  tacactaaa  gtatctaat  aagtcacac  ggtcttcca  180
tcacatgtg  tagatctgg  tgaaagaca  caactttac  agactttta  caggaatcc  240
tattataaa  actgtgtac  tgtatgtaa  cgatttgat  gggaaccca  ttaatgggc  300
tccatctcc  ctaagtcat  cattttgtt  catatttta  tttaaacgc  taacgggtg  360
gtcaaactg  tatgtttaa  tctggatac  ttatctaaa  aaatcccct  ttaccccca  420
tgaattata  atgaaagct  attttgtct  gtcccaaac  gctattact  tgaatttgt  480
tccaagaaa  ttaacagaa  aaagattga  tgaattttt  cccacactg  a  531



<210> 6660
<211> 448
<212> PRT
<213> Rattus norvegicus
<308> Q63764
<400> 6660

Met Lys Gly Phe Ile Asp Asp Ala Asn Tyr Ser Val Gly Leu Leu Asp 
  1               5                  10                  15
Glu Gly Thr Asn Leu Gly Asn Val Ile Asp Asn Tyr Val Tyr Glu His 
             20                  25                  30
Thr Leu Thr Gly Lys Asn Ala Phe Phe Val Gly Asp Leu Gly Lys Ile 
         35                  40                  45
Val Lys Lys His Ser Gln Trp Gln Asn Val Val Ala Gln Ile Lys Pro 
     50                  55                  60
Phe Tyr Met Val Lys Cys Asn Ser Thr Pro Ala Val Leu Glu Ile Leu 
 65                  70                  75                  80
Ala Ala Leu Gly Thr Gly Phe Ala Cys Ser Thr Lys Asn Glu Met Ala 
                 85                  90                  95
Leu Val Gln Glu Leu Gly Val Ser Pro Glu Asn Ile Ile Tyr Thr Ser 
             100                105                110
Pro Cys Lys Gln Ala Ser Gln Ile Lys Tyr Ala Ala Lys Val Gly Val 
         115                120                125
Asn Ile Met Thr Cys Asp Asn Glu Val Glu Leu Lys Lys Ile Ala Arg 
     130                135                140
Asn His Pro Asn Ala Lys Val Leu Leu His Ile Ala Thr Glu Asp Asn 
 145                150                155                160
Ile Gly Gly Glu Asp Gly Asn Met Lys Phe Gly Thr Thr Leu Lys Asn 
                 165                170                175
Cys Arg His Leu Leu Glu Cys Ala Lys Glu Leu Asp Val Gln Ile Ile 
             180                185                190
Gly Val Lys Phe His Ile Ser Ser Ala Cys Lys Glu Tyr Gln Val Tyr 
         195                200                205
Val His Ala Leu Ser Asp Ala Arg Cys Val Phe Asp Met Ala Gly Glu 
     210                215                220
Phe Gly Phe Thr Met Asn Met Leu Asp Ile Gly Gly Gly Phe Thr Gly 
 225                230                235                240
Thr Glu Ile Gln Leu Glu Glu Val Asn His Val Ile Ser Pro Leu Leu 
                 245                250                255
Asp Ile Tyr Phe Pro Glu Gly Ser Gly Ile Gln Ile Ile Ser Glu Pro 
             260                265                270
Gly Ser Tyr Tyr Val Ser Ser Ala Phe Thr Leu Ala Val Asn Ile Ile 
         275                280                285
Ala Lys Lys Val Val Glu Asn Asp Lys Leu Ser Ser Gly Val Glu Lys 
     290                295                300
Asn Gly Ser Asp Glu Pro Ala Phe Val Tyr Tyr Met Asn Asp Gly Val 
 305                310                315                320
Tyr Gly Ser Phe Ala Ser Lys Leu Ser Glu Asp Leu Asn Thr Val Pro 
                 325                330                335
Glu Val His Lys Lys Tyr Lys Glu Asp Glu Pro Leu Phe Thr Ser Ser 
             340                345                350
Leu Trp Gly Pro Ser Cys Asp Glu Leu Asp Gln Ile Val Glu Ser Cys 
         355                360                365
Leu Leu Pro Glu Leu Ser Val Gly Asp Trp Leu Ile Phe Asp Asn Met 
     370                375                380
Gly Ala Asp Ser Leu His Gly Pro Ser Ala Phe Ser Asp Thr Gln Arg 
 385                390                395                400
Pro Ala Ile Tyr Phe Met Met Ser Leu Ser Asp Trp Tyr Glu Met Gln 
                 405                410                415
Asp Ala Gly Ile Thr Ser Asp Ala Met Met Lys Asn Phe Phe Phe Ala 
             420                425                430
Pro Ser Cys Ile Gln Leu Ser Gln Glu Asp Asn Phe Ser Thr Glu Ala 
         435                440                445



<210> 6661
<211> 2619
<212> DNA
<213> Homo sapiens
<308> D88674
<400> 6661

agtttttcc  tttttcttc  gccgtcgcc  tctctgcct  ttctcatcc  ttctcgctc  60
gctgctctg  agtgtgacg  gtccgaatc  tcttcccac  cagcccgcg  ctttcttct  120
ttgcctgcg  tgttctatt  ctccttcgg  cgccgccgc  actgctgca  acagctggt  180
tcggtgccg  gcttttacc  ccaagtcgt  cccgcagcc  atggcccag  ccgccttgg  240
tatttctgc  caaggtaac  acatccctc  ttaaaaatt  cgccgaaaa  gagaagacg  300
tttacccga  tctttgggc  gttatctca  ggcgaactt  ctgaccaag  atacaacta  360
ccagagggc  taggagaag  gctgtatag  gagcagttc  acttcaacg  tgagccacc  420
tgggaacct  gctgatgat  ggggggttc  atctcccaa  ttgtccatg  aggtcttca  480
ttcagaaat  caagactca  attcatcca  cttggtgtc  agtgggctg  tgctgccag  540
attatcttg  gattatttg  gagatgtat  agtttcttc  gaagtacaa  caactgtag  600
agcctttgt  gcagtttgt  gcatattct  aggacccag  cataggctt  gtggcccgt  660
tcttgtctt  cctggttta  gactttcgg  tttgtggaa  acggctgag  tgaaaggat  720
tattgatga  gcaaactac  ccgttggcc  gttggatga  ggaacagac  ttggaaatg  780
tattgataa  tatgtttat  aacataccc  gacagggaa  aatgcattt  ttgtgggag  840
tcttggaaa  attgtgaag  aacacagtc  atggcagaa  gtagtggct  agataaagc  900
attctacac  gtgaagtgc  actctgctc  agctgtact  gagattttg  cagctcttg  960
aaccggatt  gcttgttcc  gtaaaaatg  aatggcttt  gtgcaagag  tgggtgtac  1020
tccagaaaa  attatttac  taagtcctt  caagcaagt  tctcagata  agtatgcag  1080
aaaagttgg  gtgaatatc  tgacatgtg  caatgaaat  gaattgaag  aaattgcac  1140
taatcaccc  aatgccaag  tcttactac  tattgcaac  gaagataat  ttggaggtg  1200
agagggtaa  atgaagttt  gcactaccc  gaagaactg  aggcatctc  tggaatgtg  1260
taaggaact  gatgtccaa  taattgggg  taaatttca  gtttcgagt  cttgcaaag  1320
atctcaagt  tatgtacat  ctctatctg  tgctcgatg  gtgtttgac  tggctggag  1380
aattggctt  acgatgaac  tgttagaca  tggtggagg  ttcacggga  ctgaatttc  1440
attggaaga  gttaatcat  ttatcagcc  tctgttgga  atctacttt  ctgaaggat  1500
tggtgttaa  ataatttca  aacccggaa  ctactatgt  tcttctgca  ttacactcg  1560
agttaatat  atagcaaag  aagttgttg  aaatgataa  tttccctct  gagtagaaa  1620
aaccggaag  gatgaacca  ccttcatgt  ttatatgaa  gatggtgtt  atggttctt  1680
tgcaagtaa  ctgtctgag  acttaaata  cattccaga  gttcacaag  aatacaagg  1740
agatgagcc  ctgtttaca  gcagccttt  gggtccatc  tgtgatgag  ttgatcaaa  1800
tgtggaaag  tgtcttctt  ctgagctga  tgtgggaga  tggcttatc  ttgataaca  1860
gggagcaga  tctttccat  aaccatctg  ttttaatga  tttcagagg  cagccattt  1920
ttacatgat  tcattcagt  attggtatg  gatgcaaga  gctggaatt  cttcagact  1980
aatgatgaa  aacttcttc  ttgtgcctt  ttgcattca  ctgagccaa  aagacagct  2040
ttccgctga  gcttaaaca  gcattaacg  ttctttaga  ctgaagttg  aggttaagc  2100
tgtctggtc  acattccag  gtggaaaaa  aatttaaac  atcttattc  cttaattct  2160
ttggcaaca  aaactatta  taatagcta  ttgggacca  acaaaatca  ctttcatct  2220
taattcatt  gggataatg  gagatttag  taatgtatc  agatttaaa  ctaccagtt  2280
gtcctaccc  ttaagcgtt  aaaataaaa  atgcaacaa  atggatgac  tagtggaga  2340
ggaagccca  taattgggt  ccccattaa  tcgtttaca  acaagaaca  agtttttat  2400
ctaaggatt  gtgtttaaa  tcttgtaaa  ttcatgtct  tcacccaga  atatcaaat  2460
ttagaagac  agtgtgact  cattagata  cgtttagtg  atttagaat  tgtaaattt  2520
tgctttgaa  tgtagttta  taaatgtaa  attgcatca  agtatttgt  gacctaatg  2580
aacccttgt  tgattgcaa  aaaattttg  gtagatttt  2619



<210> 6662
<211> 448
<212> PRT
<213> Homo sapiens
<308> O14977
<400> 6662

Met Lys Gly Phe Ile Asp Asp Ala Asn Tyr Ser Val Gly Leu Leu Asp 
  1               5                  10                  15
Glu Gly Thr Asp Leu Gly Asn Val Ile Asp Asn Tyr Val Tyr Glu His 
             20                  25                  30
Thr Leu Thr Gly Lys Asn Ala Phe Phe Val Gly Asp Leu Gly Lys Ile 
         35                  40                  45
Val Lys Lys His Ser Gln Trp Gln Asn Val Val Ala Gln Ile Lys Pro 
     50                  55                  60
Phe Tyr Thr Val Lys Cys Asn Ser Ala Pro Ala Val Leu Glu Ile Leu 
 65                  70                  75                  80
Ala Ala Leu Gly Thr Gly Phe Ala Cys Ser Ser Lys Asn Glu Met Ala 
                 85                  90                  95
Leu Val Gln Glu Leu Gly Val Pro Pro Glu Asn Ile Ile Tyr Ile Ser 
             100                105                110
Pro Cys Lys Gln Val Ser Gln Ile Lys Tyr Ala Ala Lys Val Gly Val 
         115                120                125
Asn Ile Leu Thr Cys Asp Asn Glu Ile Glu Leu Lys Lys Ile Ala Arg 
     130                135                140
Asn His Pro Asn Ala Lys Val Leu Leu His Ile Ala Thr Glu Asp Asn 
 145                150                155                160
Ile Gly Gly Glu Glu Gly Asn Met Lys Phe Gly Thr Thr Leu Lys Asn 
                 165                170                175
Cys Arg His Leu Leu Glu Cys Ala Lys Glu Leu Asp Val Gln Ile Ile 
             180                185                190
Gly Val Lys Phe His Val Ser Ser Ala Cys Lys Glu Ser Gln Val Tyr 
         195                200                205
Val His Ala Leu Ser Asp Ala Arg Cys Val Phe Asp Met Ala Gly Glu 
     210                215                220
Ile Gly Phe Thr Met Asn Met Leu Asp Ile Gly Gly Gly Phe Thr Gly 
 225                230                235                240
Thr Glu Phe Gln Leu Glu Glu Val Asn His Val Ile Ser Pro Leu Leu 
                 245                250                255
Asp Ile Tyr Phe Pro Glu Gly Ser Gly Val Lys Ile Ile Ser Glu Pro 
             260                265                270
Gly Ser Tyr Tyr Val Ser Ser Ala Phe Thr Leu Ala Val Asn Ile Ile 
         275                280                285
Ala Lys Lys Val Val Glu Asn Asp Lys Phe Pro Ser Gly Val Glu Lys 
     290                295                300
Thr Gly Ser Asp Glu Pro Ala Phe Met Tyr Tyr Met Asn Asp Gly Val 
 305                310                315                320
Tyr Gly Ser Phe Ala Ser Lys Leu Ser Glu Asp Leu Asn Thr Ile Pro 
                 325                330                335
Glu Val His Lys Lys Tyr Lys Glu Asp Glu Pro Leu Phe Thr Ser Ser 
             340                345                350
Leu Trp Gly Pro Ser Cys Asp Glu Leu Asp Gln Ile Val Glu Ser Cys 
         355                360                365
Leu Leu Pro Glu Leu Asn Val Gly Asp Trp Leu Ile Phe Asp Asn Met 
     370                375                380
Gly Ala Asp Ser Phe His Glu Pro Ser Ala Phe Asn Asp Phe Gln Arg 
 385                390                395                400
Pro Ala Ile Tyr Tyr Met Met Ser Phe Ser Asp Trp Tyr Glu Met Gln 
                 405                410                415
Asp Ala Gly Ile Thr Ser Asp Ser Met Met Lys Asn Phe Phe Phe Val 
             420                425                430
Pro Ser Cys Ile Gln Leu Ser Gln Glu Asp Ser Phe Ser Ala Glu Ala 
         435                440                445



<210> 6663
<211> 531
<212> DNA
<213> Rattus norvegicus
<308> AI043631
<400> 6663

ttttttttt  tttttttaa  atctacaca  agttttatt  caatcatac  aggttacat  60
aggtcaaat  caacaaata  tatgatgca  ttttacatt  attaaacta  agtccaaag  120
acaaattta  acactctaa  tacactaaa  gtatctaat  aagtcacac  ggtcttcca  180
tcacatgtg  tagatctgg  tgaaagaca  caactttac  agactttta  caggaatcc  240
tattataaa  actgtgtac  tgtatgtaa  cgatttgat  gggaaccca  ttaatgggc  300
tccatctcc  ctaagtcat  cattttgtt  catatttta  tttaaacgc  taacgggtg  360
gtcaaactg  tatgtttaa  tctggatac  ttatctaaa  aaatcccct  ttaccccca  420
tgaattata  atgaaagct  attttgtct  gtcccaaac  gctattact  tgaatttgt  480
tccaagaaa  ttaacagaa  aaagattga  tgaattttt  cccacactg  a  531



<210> 6664
<211> 448
<212> PRT
<213> Rattus norvegicus
<308> Q63764
<400> 6664

Met Lys Gly Phe Ile Asp Asp Ala Asn Tyr Ser Val Gly Leu Leu Asp 
  1               5                  10                  15
Glu Gly Thr Asn Leu Gly Asn Val Ile Asp Asn Tyr Val Tyr Glu His 
             20                  25                  30
Thr Leu Thr Gly Lys Asn Ala Phe Phe Val Gly Asp Leu Gly Lys Ile 
         35                  40                  45
Val Lys Lys His Ser Gln Trp Gln Asn Val Val Ala Gln Ile Lys Pro 
     50                  55                  60
Phe Tyr Met Val Lys Cys Asn Ser Thr Pro Ala Val Leu Glu Ile Leu 
 65                  70                  75                  80
Ala Ala Leu Gly Thr Gly Phe Ala Cys Ser Thr Lys Asn Glu Met Ala 
                 85                  90                  95
Leu Val Gln Glu Leu Gly Val Ser Pro Glu Asn Ile Ile Tyr Thr Ser 
             100                105                110
Pro Cys Lys Gln Ala Ser Gln Ile Lys Tyr Ala Ala Lys Val Gly Val 
         115                120                125
Asn Ile Met Thr Cys Asp Asn Glu Val Glu Leu Lys Lys Ile Ala Arg 
     130                135                140
Asn His Pro Asn Ala Lys Val Leu Leu His Ile Ala Thr Glu Asp Asn 
 145                150                155                160
Ile Gly Gly Glu Asp Gly Asn Met Lys Phe Gly Thr Thr Leu Lys Asn 
                 165                170                175
Cys Arg His Leu Leu Glu Cys Ala Lys Glu Leu Asp Val Gln Ile Ile 
             180                185                190
Gly Val Lys Phe His Ile Ser Ser Ala Cys Lys Glu Tyr Gln Val Tyr 
         195                200                205
Val His Ala Leu Ser Asp Ala Arg Cys Val Phe Asp Met Ala Gly Glu 
     210                215                220
Phe Gly Phe Thr Met Asn Met Leu Asp Ile Gly Gly Gly Phe Thr Gly 
 225                230                235                240
Thr Glu Ile Gln Leu Glu Glu Val Asn His Val Ile Ser Pro Leu Leu 
                 245                250                255
Asp Ile Tyr Phe Pro Glu Gly Ser Gly Ile Gln Ile Ile Ser Glu Pro 
             260                265                270
Gly Ser Tyr Tyr Val Ser Ser Ala Phe Thr Leu Ala Val Asn Ile Ile 
         275                280                285
Ala Lys Lys Val Val Glu Asn Asp Lys Leu Ser Ser Gly Val Glu Lys 
     290                295                300
Asn Gly Ser Asp Glu Pro Ala Phe Val Tyr Tyr Met Asn Asp Gly Val 
 305                310                315                320
Tyr Gly Ser Phe Ala Ser Lys Leu Ser Glu Asp Leu Asn Thr Val Pro 
                 325                330                335
Glu Val His Lys Lys Tyr Lys Glu Asp Glu Pro Leu Phe Thr Ser Ser 
             340                345                350
Leu Trp Gly Pro Ser Cys Asp Glu Leu Asp Gln Ile Val Glu Ser Cys 
         355                360                365
Leu Leu Pro Glu Leu Ser Val Gly Asp Trp Leu Ile Phe Asp Asn Met 
     370                375                380
Gly Ala Asp Ser Leu His Gly Pro Ser Ala Phe Ser Asp Thr Gln Arg 
 385                390                395                400
Pro Ala Ile Tyr Phe Met Met Ser Leu Ser Asp Trp Tyr Glu Met Gln 
                 405                410                415
Asp Ala Gly Ile Thr Ser Asp Ala Met Met Lys Asn Phe Phe Phe Ala 
             420                425                430
Pro Ser Cys Ile Gln Leu Ser Gln Glu Asp Asn Phe Ser Thr Glu Ala 
         435                440                445



<210> 6665
<211> 2619
<212> DNA
<213> Homo sapiens
<308> D88674
<400> 6665

agtttttcc  tttttcttc  gccgtcgcc  tctctgcct  ttctcatcc  ttctcgctc  60
gctgctctg  agtgtgacg  gtccgaatc  tcttcccac  cagcccgcg  ctttcttct  120
ttgcctgcg  tgttctatt  ctccttcgg  cgccgccgc  actgctgca  acagctggt  180
tcggtgccg  gcttttacc  ccaagtcgt  cccgcagcc  atggcccag  ccgccttgg  240
tatttctgc  caaggtaac  acatccctc  ttaaaaatt  cgccgaaaa  gagaagacg  300
tttacccga  tctttgggc  gttatctca  ggcgaactt  ctgaccaag  atacaacta  360
ccagagggc  taggagaag  gctgtatag  gagcagttc  acttcaacg  tgagccacc  420
tgggaacct  gctgatgat  ggggggttc  atctcccaa  ttgtccatg  aggtcttca  480
ttcagaaat  caagactca  attcatcca  cttggtgtc  agtgggctg  tgctgccag  540
attatcttg  gattatttg  gagatgtat  agtttcttc  gaagtacaa  caactgtag  600
agcctttgt  gcagtttgt  gcatattct  aggacccag  cataggctt  gtggcccgt  660
tcttgtctt  cctggttta  gactttcgg  tttgtggaa  acggctgag  tgaaaggat  720
tattgatga  gcaaactac  ccgttggcc  gttggatga  ggaacagac  ttggaaatg  780
tattgataa  tatgtttat  aacataccc  gacagggaa  aatgcattt  ttgtgggag  840
tcttggaaa  attgtgaag  aacacagtc  atggcagaa  gtagtggct  agataaagc  900
attctacac  gtgaagtgc  actctgctc  agctgtact  gagattttg  cagctcttg  960
aaccggatt  gcttgttcc  gtaaaaatg  aatggcttt  gtgcaagag  tgggtgtac  1020
tccagaaaa  attatttac  taagtcctt  caagcaagt  tctcagata  agtatgcag  1080
aaaagttgg  gtgaatatc  tgacatgtg  caatgaaat  gaattgaag  aaattgcac  1140
taatcaccc  aatgccaag  tcttactac  tattgcaac  gaagataat  ttggaggtg  1200
agagggtaa  atgaagttt  gcactaccc  gaagaactg  aggcatctc  tggaatgtg  1260
taaggaact  gatgtccaa  taattgggg  taaatttca  gtttcgagt  cttgcaaag  1320
atctcaagt  tatgtacat  ctctatctg  tgctcgatg  gtgtttgac  tggctggag  1380
aattggctt  acgatgaac  tgttagaca  tggtggagg  ttcacggga  ctgaatttc  1440
attggaaga  gttaatcat  ttatcagcc  tctgttgga  atctacttt  ctgaaggat  1500
tggtgttaa  ataatttca  aacccggaa  ctactatgt  tcttctgca  ttacactcg  1560
agttaatat  atagcaaag  aagttgttg  aaatgataa  tttccctct  gagtagaaa  1620
aaccggaag  gatgaacca  ccttcatgt  ttatatgaa  gatggtgtt  atggttctt  1680
tgcaagtaa  ctgtctgag  acttaaata  cattccaga  gttcacaag  aatacaagg  1740
agatgagcc  ctgtttaca  gcagccttt  gggtccatc  tgtgatgag  ttgatcaaa  1800
tgtggaaag  tgtcttctt  ctgagctga  tgtgggaga  tggcttatc  ttgataaca  1860
gggagcaga  tctttccat  aaccatctg  ttttaatga  tttcagagg  cagccattt  1920
ttacatgat  tcattcagt  attggtatg  gatgcaaga  gctggaatt  cttcagact  1980
aatgatgaa  aacttcttc  ttgtgcctt  ttgcattca  ctgagccaa  aagacagct  2040
ttccgctga  gcttaaaca  gcattaacg  ttctttaga  ctgaagttg  aggttaagc  2100
tgtctggtc  acattccag  gtggaaaaa  aatttaaac  atcttattc  cttaattct  2160
ttggcaaca  aaactatta  taatagcta  ttgggacca  acaaaatca  ctttcatct  2220
taattcatt  gggataatg  gagatttag  taatgtatc  agatttaaa  ctaccagtt  2280
gtcctaccc  ttaagcgtt  aaaataaaa  atgcaacaa  atggatgac  tagtggaga  2340
ggaagccca  taattgggt  ccccattaa  tcgtttaca  acaagaaca  agtttttat  2400
ctaaggatt  gtgtttaaa  tcttgtaaa  ttcatgtct  tcacccaga  atatcaaat  2460
ttagaagac  agtgtgact  cattagata  cgtttagtg  atttagaat  tgtaaattt  2520
tgctttgaa  tgtagttta  taaatgtaa  attgcatca  agtatttgt  gacctaatg  2580
aacccttgt  tgattgcaa  aaaattttg  gtagatttt  2619



<210> 6666
<211> 448
<212> PRT
<213> Homo sapiens
<308> O14977
<400> 6666

Met Lys Gly Phe Ile Asp Asp Ala Asn Tyr Ser Val Gly Leu Leu Asp 
  1               5                  10                  15
Glu Gly Thr Asp Leu Gly Asn Val Ile Asp Asn Tyr Val Tyr Glu His 
             20                  25                  30
Thr Leu Thr Gly Lys Asn Ala Phe Phe Val Gly Asp Leu Gly Lys Ile 
         35                  40                  45
Val Lys Lys His Ser Gln Trp Gln Asn Val Val Ala Gln Ile Lys Pro 
     50                  55                  60
Phe Tyr Thr Val Lys Cys Asn Ser Ala Pro Ala Val Leu Glu Ile Leu 
 65                  70                  75                  80
Ala Ala Leu Gly Thr Gly Phe Ala Cys Ser Ser Lys Asn Glu Met Ala 
                 85                  90                  95
Leu Val Gln Glu Leu Gly Val Pro Pro Glu Asn Ile Ile Tyr Ile Ser 
             100                105                110
Pro Cys Lys Gln Val Ser Gln Ile Lys Tyr Ala Ala Lys Val Gly Val 
         115                120                125
Asn Ile Leu Thr Cys Asp Asn Glu Ile Glu Leu Lys Lys Ile Ala Arg 
     130                135                140
Asn His Pro Asn Ala Lys Val Leu Leu His Ile Ala Thr Glu Asp Asn 
 145                150                155                160
Ile Gly Gly Glu Glu Gly Asn Met Lys Phe Gly Thr Thr Leu Lys Asn 
                 165                170                175
Cys Arg His Leu Leu Glu Cys Ala Lys Glu Leu Asp Val Gln Ile Ile 
             180                185                190
Gly Val Lys Phe His Val Ser Ser Ala Cys Lys Glu Ser Gln Val Tyr 
         195                200                205
Val His Ala Leu Ser Asp Ala Arg Cys Val Phe Asp Met Ala Gly Glu 
     210                215                220
Ile Gly Phe Thr Met Asn Met Leu Asp Ile Gly Gly Gly Phe Thr Gly 
 225                230                235                240
Thr Glu Phe Gln Leu Glu Glu Val Asn His Val Ile Ser Pro Leu Leu 
                 245                250                255
Asp Ile Tyr Phe Pro Glu Gly Ser Gly Val Lys Ile Ile Ser Glu Pro 
             260                265                270
Gly Ser Tyr Tyr Val Ser Ser Ala Phe Thr Leu Ala Val Asn Ile Ile 
         275                280                285
Ala Lys Lys Val Val Glu Asn Asp Lys Phe Pro Ser Gly Val Glu Lys 
     290                295                300
Thr Gly Ser Asp Glu Pro Ala Phe Met Tyr Tyr Met Asn Asp Gly Val 
 305                310                315                320
Tyr Gly Ser Phe Ala Ser Lys Leu Ser Glu Asp Leu Asn Thr Ile Pro 
                 325                330                335
Glu Val His Lys Lys Tyr Lys Glu Asp Glu Pro Leu Phe Thr Ser Ser 
             340                345                350
Leu Trp Gly Pro Ser Cys Asp Glu Leu Asp Gln Ile Val Glu Ser Cys 
         355                360                365
Leu Leu Pro Glu Leu Asn Val Gly Asp Trp Leu Ile Phe Asp Asn Met 
     370                375                380
Gly Ala Asp Ser Phe His Glu Pro Ser Ala Phe Asn Asp Phe Gln Arg 
 385                390                395                400
Pro Ala Ile Tyr Tyr Met Met Ser Phe Ser Asp Trp Tyr Glu Met Gln 
                 405                410                415
Asp Ala Gly Ile Thr Ser Asp Ser Met Met Lys Asn Phe Phe Phe Val 
             420                425                430
Pro Ser Cys Ile Gln Leu Ser Gln Glu Asp Ser Phe Ser Ala Glu Ala 
         435                440                445



<210> 6667
<211> 363
<212> DNA
<213> Rattus norvegicus
<308> AI044716
<400> 6667

cggccgcaa  ggtgtgttg  ggaccagga  gttaaaaag  taggccctc  ctcgatggt  60
ggttctttg  gttggagct  aatggttac  tggaaggag  tgagaattt  gataccagt  120
ctgagcttg  tagaagaaa  tagggtcac  ctggctaac  taagggtac  gcatcctta  180
taacccgag  gtggctcga  gcgttcatg  tttcatcca  aacacaaca  gtaaactta  240
tcagctaac  atggggaaa  gtattgctt  tgtgcgcag  ggacttatg  gcaatttgt  300
caaaaggga  caagtcatt  aggagaaac  agcccaata  ttagagtcc  aattttgtc  360
tat  363



<210> 6668
<211> 432
<212> PRT
<213> Rattus norvegicus
<308> P47971
<400> 6668

Met Leu Ala Gly Arg Ala Ala Arg Thr Cys Ala Leu Leu Ala Leu Cys 
  1               5                  10                  15
Leu Leu Gly Ser Arg Ala Gln Asp Phe Gly Pro Thr Arg Phe Ile Cys 
             20                  25                  30
Thr Ser Val Pro Val Asp Ala Asp Met Cys Ala Ala Ser Val Ala Ala 
         35                  40                  45
Gly Gly Ala Glu Glu Leu Arg Ser Asn Val Leu Gln Leu Arg Glu Thr 
     50                  55                  60
Val Leu Gln Gln Lys Glu Thr Ile Leu Ser Gln Lys Glu Thr Ile Arg 
 65                  70                  75                  80
Glu Leu Thr Thr Lys Leu Gly Arg Cys Glu Ser Gln Ser Thr Leu Asp 
                 85                  90                  95
Ala Gly Pro Gly Glu Ala Arg Ser Gly Gly Gly Arg Lys Gln Pro Gly 
             100                105                110
Ser Gly Lys Asn Thr Met Gly Asp Leu Ser Arg Thr Pro Ala Ser Glu 
         115                120                125
Thr Leu Ser Gln Leu Gly Gln Thr Leu Gln Ser Leu Lys Thr Arg Leu 
     130                135                140
Glu Asn Leu Glu Gln Tyr Ser Arg Leu Asn Ser Ser Ser Gln Thr Asn 
 145                150                155                160
Ser Leu Lys Asp Leu Leu Gln Ser Lys Ile Asp Asp Leu Glu Arg Gln 
                 165                170                175
Val Leu Ser Arg Val Asn Thr Leu Glu Glu Gly Lys Gly Gly Pro Lys 
             180                185                190
Asn Asp Thr Glu Glu Arg Ala Lys Ile Glu Ser Ala Leu Thr Ser Leu 
         195                200                205
His Gln Arg Ile Ser Glu Leu Glu Lys Gly Gln Lys Asp Asn Arg Pro 
     210                215                220
Gly Asp Lys Phe Gln Leu Thr Phe Pro Leu Arg Thr Asn Tyr Met Tyr 
 225                230                235                240
Ala Lys Val Lys Lys Ser Leu Pro Glu Met Tyr Ala Phe Thr Val Cys 
                 245                250                255
Met Trp Leu Lys Ser Ser Ala Ala Pro Gly Val Gly Thr Pro Phe Ser 
             260                265                270
Tyr Ala Val Pro Gly Gln Ala Asn Glu Leu Val Leu Ile Glu Trp Gly 
         275                280                285
Asn Asn Pro Met Glu Ile Leu Ile Asn Asp Lys Val Ala Lys Leu Pro 
     290                295                300
Phe Val Ile Asn Asp Gly Lys Trp His His Ile Cys Val Thr Trp Thr 
 305                310                315                320
Thr Arg Asp Gly Val Trp Glu Ala Tyr Gln Asp Gly Thr Gln Gly Gly 
                 325                330                335
Asn Gly Glu Asn Leu Ala Pro Tyr His Pro Ile Lys Pro Gln Gly Val 
             340                345                350
Leu Val Leu Gly Gln Glu Gln Asp Thr Leu Gly Gly Gly Phe Asp Ala 
         355                360                365
Thr Gln Ala Phe Val Gly Glu Leu Ala His Phe Asn Ile Trp Asp Arg 
     370                375                380
Lys Leu Thr Pro Gly Glu Val Tyr Asn Leu Ala Thr Cys Ser Ser Lys 
 385                390                395                400
Ala Leu Ser Gly Asn Val Ile Ala Trp Ala Glu Ser Gln Ile Glu Ile 
                 405                410                415
Phe Gly Gly Ala Thr Lys Trp Thr Phe Glu Ala Cys Arg Gln Ile Asn 
             420                425                430



<210> 6669
<211> 5071
<212> DNA
<213> Homo sapiens
<308> U61849
<400> 6669

ggcctgata  cgcggcgtg  ggaccggcc  aagagcgcg  ccagagcgg  gccgtcgcg  60
gccacagcc  gagccggtc  cagccgagc  gagccccag  cgagccgag  cggcccgag  120
gctccggtg  ccgcagcca  gccggccgg  cgcgcgcgc  cctgtgcgc  gctcgccct  180
tgcctcctg  ggccccagg  tttcgggcc  acgcgcttc  tctgcactt  ggtgccggt  240
gacgccgac  tgtgtgccg  gtccgtggc  gcgggcggc  cggaggagc  ccggagcag  300
aatgtgctg  agctccggg  gaccgtgct  cagcagaag  agaccatcc  gagccagaa  360
gagaccatc  gcgagctga  cgccaagct  ggccgctgc  agagccaga  cacgctgga  420
cccggagcc  gcgaggccc  ggcgggcgg  ggccgcaag  agccgggct  gggcaagaa  480
accatgggc  acctgtccc  gacaccggc  gccgagacg  tcagccaac  cgggcaaac  540
ttgcaatcg  tcaaaaccc  cctggagaa  ctcgagcag  acagccgcc  caattcctc  600
agccagacc  acagcctca  ggatctgct  cagagcaag  tcgatgagc  ggagaggca  660
gtgctgtcc  gggtgaaca  cctggagga  ggcaagggg  ggcccaaga  cgacaccga  720
gagagggtc  agatcgaga  cgccctgac  tccctgcac  agcggatca  cgagctcga  780
aaaggtcag  aagacaacc  ccctggaga  aagttccag  tcacattcc  actgcggac  840
aactatatg  atgccaagg  gaagaagag  ctgccagag  tgtacgcct  cactgtctg  900
atgtggctc  agtccagcg  cacgccagg  gtgggcacg  ccttctcct  cgctgtgcc  960
ggccaggcc  acgagctgg  cctcattga  tggggcaac  accccatgg  gatcctcat  1020
aatgacaag  tggccaagc  gccttttgt  atcaatgat  gcaagtggc  ccacatctg  1080
gtcacctgg  ccacccggg  cggggtctg  gaggcctac  aggatggca  gcagggtgg  1140
agtggcgag  acttggcgc  ctatcaccc  atcaagccc  agggcgtgc  ggtgctggg  1200
caggagcag  acactctgg  tggtgggtt  gatgccacc  aggcatttg  gggtgagct  1260
gcccacttc  acatctggg  ccgcaagct  acccccggg  aggtgtaca  cctggccac  1320
tgcagcacc  aggctctgt  cggcaatgt  atcgcctgg  ctgaatccc  catcgagat  1380
tacggcggg  ccaccaagt  gaccttcga  gcctgtcgc  agatcaact  agcacggca  1440
gccaggctg  gccgcccgc  ctcgccccc  gcttgtgcg  cgatgatct  tttgtgcgt  1500
tcttctctc  cttttcccc  ggaatgaac  gaggccgtc  ccctgcaca  gcacacgca  1560
acagcctgg  tttgtcctc  tgcacacga  gcagcccct  ctcccatct  tccctgagg  1620
agccccact  ctctgtagg  gcccggact  tctcagcat  ccccattca  agctgaagt  1680
ggtgctgca  cgtcttgaa  aaggcagaa  ttggtgaga  gatctgtgt  tgcgtgtct  1740
catgtgtgt  tctacgtgt  tgcgtgcgt  gctggggga  gccttttct  tgaggacgt  1800
cctcatttc  ttctttctt  tggctttgg  aaaatctca  gatgaaaat  catatttgc  1860
aactttgtt  gctgcgtgc  tgctttggg  ttggtgcaa  ctcagtaca  gcatttgtc  1920
ttgtttgca  acctttctc  gagcgacat  tctttatat  gatgtaata  atgtctttt  1980
gtggtttgt  aaaggccgg  ggcgggggc  ctctacaga  aatttttat  ttgtaatag  2040
agtgaactg  ctctgaagg  gaaggcagg  cgtcctggg  tggtaccct  tgctctccc  2100
tggaggaga  gggatggct  aggacactg  cccttaccc  gggcgaaca  catccatcc  2160
tgctgtttg  atcttgaga  cagcatggg  cctgggagg  cggcctgtg  gcccagctc  2220
gctagctct  ccccaggac  gccctgccc  cgaccttcc  acctcctca  atcctgcaa  2280
gctgggtct  cccctccct  ctcacctct  gagctgtgc  gcactgctt  ccagagagg  2340
ccctgagag  ggagcgtgc  acccaccag  gaagccggg  cccagcacc  ctctccttt  2400
gcctcccgg  gtgcagacc  gaggggacc  tttaaggaa  gaagccgtg  ttcgatgaa  2460
acctggcca  atggggcac  gggacttca  cccagccca  cggtgggaa  gtccttttt  2520
ggggacttt  acagccata  ccctcccag  acaccaggc  ccaggtgag  tggttcaga  2580
ccctccagg  tactccaga  acctcacgt  tggagccag  cctggccag  caggggcct  2640
aaacccact  ctccatctc  tgggctcac  gcctacacg  gcccacaag  tgccactgg  2700
cggcgacac  gacacctga  cagtgtcca  aaccttttt  ccttttttt  ttccccgtg  2760
aaagcaaca  ggacatttc  ttctagtcc  tccaaggag  ggagagaag  gtatgtgca  2820
ttgtgtgtg  gtgtgtgtg  tgtgtgtgt  tgtgcgcta  gtgagaaag  gagcaggct  2880
gggaggccc  gcccagggt  ggaggagct  cctgctttg  accatctgg  ggtcgcacc  2940
tggagggca  cccgactct  tctccagga  tctcatcag  aaaccgctg  caagtcttt  3000
tagaaattc  actgcactg  ctggctcag  tgcacgctg  agacatttc  gcaggagga  3060
caggtgttt  tgtcttctg  tccttctag  gccacctgt  cccttaaac  caggtccac  3120
ttgtgtcaa  aacctagtg  atctgtgtg  gtctgtcag  gtctctgtg  cagtgttct  3180
gtgggtgtc  gcacggtac  ggcccgcct  ctgcaatca  cactcccgc  gagggggtg  3240
agatcaggc  ccgtgctgc  gttgttgtt  aacagtgct  tttcttaga  agcgtcttc  3300
tcagcgccc  tcggttgtg  catccttga  ctcagggat  ttctccgtt  gcatgtcct  3360
ggagtggcg  gttccttct  cctgggtcc  acatgtgtt  ccgcacctg  atggactgc  3420
ccggttctg  gttgtgtgc  gagtgccgc  cagtgttct  tgaccaccc  tgtagctac  3480
gaaaatggc  gggtaagca  gtcaagggt  ttggaggag  tcaagagag  gctcagttt  3540
cctctcccc  tccccaaac  caccaagaa  catttttaa  gtgtaggtt  agaacaagc  3600
taaaggatt  ccacagctg  gagccagca  gagagcttg  agtcgcctc  ctagaccag  3660
tctagcccc  ccctcactc  agccatctc  gagcccttg  gtaggcaac  ccggtgcgc  3720
gctgtgtgg  gtgctccct  ccagcacct  cggccagcc  cgcccctgc  gatctactg  3780
accgcagac  accttctgc  cccgtggcc  ggtgggagc  gtccgttca  gaccatgag  3840
catcctctg  cctgactag  gaggggcag  gcacacccc  gtgcttacg  ctccacccc  3900
gcagcctcc  ggcccgctc  ccttcctca  ccctcctct  acccaccca  ggtgccagg  3960
ccgaagctg  cctttagct  cctcctgcc  ttgctaggg  ctgagccaa  cccctcgac  4020
cctcactgt  ttgacactt  gcactttgc  ggccccgag  aggtcgatg  cacagccgc  4080
aatctaatc  acgtagttc  catttactc  ttaatctga  tgatgttcc  tcttgcact  4140
aataataca  gcctctctc  ggtaagcca  tttataaaa  aagaagata  aaagcactg  4200
tgaggcagt  tttgctttt  ccgagctgg  gtccgacag  tccctgggt  tccggggtg  4260
gagagctgt  gacagaagc  ctccgggcc  cagggctta  atcccactt  agtcgtaag  4320
cttcttgct  ttgataaca  agtattatt  ctcttactg  agaagaaaa  gtttattac  4380
aaacaagag  atttttatg  aagaaaagg  caaacctat  aattaactc  acctatatc  4440
cccttgaaa  tactttcag  ctccaccaa  acgtagaac  gaaagcatg  attttggaa  4500
aaagagata  attttgtat  ctttctttt  cttttgtag  ttcccagtt  attttctaa  4560
actgcaaag  tcactttgt  accagccct  ggacctgag  ccaaggggg  gtcttgtgg  4620
cagtgaggg  gtgaggaga  gctggcatg  ggttcagtc  ttccagtga  ctccaaaga  4680
gggccacct  ttctcaaaa  catgttggg  accaggagg  aaaactggc  atttatggt  4740
aacctgtgt  ttggagctg  cttactaag  ggaatgagc  gaggatttg  atatcagtt  4800
taaccttga  agaagaacc  tgggttaca  gtggttcac  ttaagagga  agaatcctt  4860
ggaatctta  ggcaaccaa  tgtggcttg  cgaagtcgt  gtttcatct  ttaaacaca  4920
tgtgtaaat  tattcaact  acgatggga  atgtattac  tctgtacac  gtggactga  4980
gtgcaattt  ttgaaaggg  acaagtcat  gaagagaaa  aaaaaaagc  caatactta  5040
agtcccaat  ttgtctcat  tgccaaaaa  a  5071



<210> 6670
<211> 430
<212> PRT
<213> Homo sapiens
<308> Q15818
<400> 6670

Met Pro Ala Gly Arg Ala Arg Thr Cys Ala Leu Leu Ala Leu Cys Leu 
  1               5                  10                  15
Leu Gly Pro Gln Asp Phe Gly Pro Thr Arg Phe Ile Cys Thr Ser Val 
             20                  25                  30
Pro Val Asp Ala Asp Met Cys Ala Ala Ser Val Ala Ala Gly Gly Ala 
         35                  40                  45
Glu Glu Leu Arg Ser Ser Asn Val Leu Gln Leu Arg Glu Thr Val Leu 
     50                  55                  60
Gln Gln Lys Glu Thr Ile Leu Ser Gln Lys Glu Thr Ile Arg Glu Leu 
 65                  70                  75                  80
Thr Ala Lys Leu Gly Arg Cys Glu Ser Gln Ser Thr Leu Asp Pro Gly 
                 85                  90                  95
Ala Gly Glu Ala Arg Ala Gly Gly Gly Arg Lys Gln Pro Gly Ser Gly 
             100                105                110
Lys Asn Thr Met Gly Asp Leu Ser Arg Thr Pro Ala Ala Glu Thr Leu 
         115                120                125
Ser Gln Leu Gly Gln Thr Leu Gln Ser Leu Lys Thr Arg Leu Glu Asn 
     130                135                140
Leu Glu Gln Tyr Ser Arg Leu Asn Ser Ser Ser Gln Thr Asn Ser Leu 
 145                150                155                160
Lys Asp Leu Leu Gln Ser Lys Ile Asp Glu Leu Glu Arg Gln Val Leu 
                 165                170                175
Ser Arg Val Asn Thr Leu Glu Glu Gly Lys Gly Gly Pro Lys Asn Asp 
             180                185                190
Thr Glu Glu Arg Val Lys Ile Glu Thr Ala Leu Thr Ser Leu His Gln 
         195                200                205
Arg Ile Ser Glu Leu Glu Lys Gly Gln Lys Asp Asn Arg Pro Gly Asp 
     210                215                220
Lys Phe Gln Leu Thr Phe Pro Leu Arg Thr Asn Tyr Met Tyr Ala Lys 
 225                230                235                240
Val Lys Lys Ser Leu Pro Glu Met Tyr Ala Phe Thr Val Cys Met Trp 
                 245                250                255
Leu Lys Ser Ser Ala Thr Pro Gly Val Gly Thr Pro Phe Ser Tyr Ala 
             260                265                270
Val Pro Gly Gln Ala Asn Glu Leu Val Leu Ile Glu Trp Gly Asn Asn 
         275                280                285
Pro Met Glu Ile Leu Ile Asn Asp Lys Val Ala Lys Leu Pro Phe Val 
     290                295                300
Ile Asn Asp Gly Lys Trp His His Ile Cys Val Thr Trp Thr Thr Arg 
 305                310                315                320
Asp Gly Val Trp Glu Ala Tyr Gln Asp Gly Thr Gln Gly Gly Ser Gly 
                 325                330                335
Glu Asn Leu Ala Pro Tyr His Pro Ile Lys Pro Gln Gly Val Leu Val 
             340                345                350
Leu Gly Gln Glu Gln Asp Thr Leu Gly Gly Gly Phe Asp Ala Thr Gln 
         355                360                365
Ala Phe Val Gly Glu Leu Ala His Phe Asn Ile Trp Asp Arg Lys Leu 
     370                375                380
Thr Pro Gly Glu Val Tyr Asn Leu Ala Thr Cys Ser Thr Lys Ala Leu 
 385                390                395                400
Ser Gly Asn Val Ile Ala Trp Ala Glu Ser His Ile Glu Ile Tyr Gly 
                 405                410                415
Gly Ala Thr Lys Trp Thr Phe Glu Ala Cys Arg Gln Ile Asn 
             420                425                430



<210> 6671
<211> 388
<212> DNA
<213> Rattus norvegicus
<308> AI044900
<400> 6671

ttttttttt  tttttttga  actgggtac  cgcattgtt  tgaggagga  ctgttcttt  60
gtgtactgg  aacacgagg  taccagcag  cacaacagg  accctttgg  acccttaca  120
accagaagg  tcacataaa  gtactgcat  tgaggtggt  agggaaagg  acaagggga  180
ggggttaag  agagaaatc  ctggtccac  gtgactttc  tcagcctgg  cagttgctc  240
taaaggggt  gctttcttc  agtgtactg  actcttcag  gcagcagac  gctgcaggg  300
gtgcagcca  cagcagacg  atcagaaag  gtaagtcct  accccttgg  tagaaaaac  360
ggagacaga  gttttaaca  ccacctta  388



<210> 6672
<211> 699
<212> PRT
<213> Rattus norvegicus
<308> P18163
<400> 6672

Met Glu Val His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Ile 
  1               5                  10                  15
Asp Ile Arg Gln Tyr Val Arg Thr Leu Pro Thr Asn Thr Leu Met Gly 
             20                  25                  30
Phe Gly Ala Phe Ala Ala Leu Thr Thr Phe Trp Tyr Ala Thr Arg Pro 
         35                  40                  45
Lys Ala Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val 
     50                  55                  60
Thr Gly Thr Thr Glu Gly Val Arg Arg Ser Ala Val Leu Glu Asp Asp 
 65                  70                  75                  80
Lys Leu Leu Leu Tyr Tyr Tyr Asp Asp Val Arg Thr Met Tyr Asp Gly 
                 85                  90                  95
Phe Gln Arg Gly Ile Gln Val Ser Asn Asp Gly Pro Cys Leu Gly Ser 
             100                105                110
Arg Lys Pro Asn Gln Pro Tyr Glu Trp Ile Ser Tyr Lys Gln Val Ala 
         115                120                125
Glu Met Ala Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys 
     130                135                140
Pro Cys Ser Glu Gln Phe Ile Gly Ile Phe Ser Gln Asn Arg Pro Glu 
 145                150                155                160
Trp Val Thr Ile Glu Gln Gly Cys Phe Thr Tyr Ser Met Val Val Val 
                 165                170                175
Pro Leu Tyr Asp Thr Leu Gly Thr Asp Ala Ile Thr Tyr Ile Val Asn 
             180                185                190
Lys Ala Glu Leu Ser Val Ile Phe Ala Asp Lys Pro Glu Lys Ala Lys 
         195                200                205
Leu Leu Leu Glu Gly Val Glu Asn Lys Leu Thr Pro Cys Leu Lys Ile 
     210                215                220
Ile Val Ile Met Asp Ser Tyr Asp Asn Asp Leu Val Glu Arg Gly Gln 
 225                230                235                240
Lys Cys Gly Val Glu Ile Ile Gly Leu Lys Ala Leu Glu Asp Leu Gly 
                 245                250                255
Arg Val Asn Arg Thr Lys Pro Lys Pro Pro Glu Pro Glu Asp Leu Ala 
             260                265                270
Ile Ile Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met 
         275                280                285
Val Thr His Gln Asn Ile Met Asn Asp Cys Ser Gly Phe Ile Lys Ala 
     290                295                300
Thr Glu Ser Ala Phe Ile Ala Ser Pro Glu Asp Val Leu Ile Ser Phe 
 305                310                315                320
Leu Pro Leu Ala His Met Phe Glu Thr Val Val Glu Cys Val Met Leu 
                 325                330                335
Cys His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu 
             340                345                350
Met Asp Asp Leu Lys Val Leu Gln Pro Thr Ile Phe Pro Val Val Pro 
         355                360                365
Arg Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Thr 
     370                375                380
Ser Val Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala 
 385                390                395                400
Glu Leu Arg Ser Gly Ile Val Arg Asn Asn Ser Leu Trp Asp Lys Leu 
                 405                410                415
Ile Phe His Lys Ile Gln Ser Ser Leu Gly Gly Lys Val Arg Leu Met 
             420                425                430
Ile Thr Gly Ala Ala Pro Val Ser Ala Thr Val Leu Thr Phe Leu Arg 
         435                440                445
Ala Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Thr Glu Cys 
     450                455                460
Thr Ala Gly Cys Cys Leu Ser Leu Pro Gly Asp Trp Thr Ala Gly His 
 465                470                475                480
Val Gly Ala Pro Met Pro Cys Asn Tyr Ile Lys Leu Val Asp Val Glu 
                 485                490                495
Asp Met Asn Tyr Gln Ala Ala Lys Gly Glu Gly Glu Val Cys Val Lys 
             500                505                510
Gly Ala Asn Val Phe Lys Gly Tyr Leu Lys Asp Pro Ala Arg Thr Ala 
         515                520                525
Glu Ala Leu Asp Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys 
     530                535                540
Trp Leu Pro Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile 
 545                550                555                560
Phe Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn 
                 565                570                575
Ile Tyr Leu Arg Ser Glu Ala Val Ala Gln Val Phe Val His Gly Glu 
             580                585                590
Ser Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Ile 
         595                600                605
Leu Pro Ser Trp Ala Gln Lys Arg Gly Phe Gln Gly Ser Phe Glu Glu 
     610                615                620
Leu Cys Arg Asn Lys Asp Ile Asn Lys Ala Ile Leu Glu Asp Met Val 
 625                630                635                640
Lys Leu Gly Lys Asn Ala Gly Leu Lys Pro Phe Glu Gln Val Lys Gly 
                 645                650                655
Ile Ala Val His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Thr 
             660                665                670
Pro Thr Leu Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser 
         675                680                685
Gln Ile Asp Glu Leu Tyr Ser Thr Ile Lys Ile 
     690                695



<210> 6673
<211> 3634
<212> DNA
<213> Homo sapiens
<308> D10040
<400> 6673

tcaacacag  acaatgcaa  cccatgagc  gttccggta  tttcgaatg  cagagctgg  60
tgacttccg  cagtacgtg  gtactcttc  gaccaacac  cttatgggc  tcggagctt  120
tgcagcact  accaccttc  ggtacgcca  gagacccaa  cccctgaag  cgccatgcg  180
cctctccat  cagtcagtg  aagtggcgg  tagtggtgg  gcacgaaga  ccgcactac  240
tgacagcga  gagcccttg  tgtatttct  tgatgatgt  acaacatta  acgaaggtt  300
ccagagggg  atacaggtg  caaataatg  cccttgttt  ggctctcgg  aaccagacc  360
accctatga  tggctttca  ataaacagg  tgcagaatt  tcggagtgc  taggctcag  420
actgatcca  aagggcttc  agactgccc  agatcagtt  attggcatc  ttgctcaaa  480
tagacctga  tgggtgatt  ttgaacaag  atgctttgc  tattcgatg  tgatcgttc  540
actttatga  acccttgga  atgaagcca  cacgtacat  gtcaacaaa  ctgaactct  600
tctggtttt  gttgacaag  cagagaagg  caaactctt  ttagagggt  tagaaaata  660
gttaatacc  ggccttaaa  tcatagttg  catggatgc  tacggcagt  aactggtgg  720
acgaggcca  aggtgtggg  tggaagtca  cagcatgaa  gcgatggag  acctgggaa  780
agccaacag  cggaagccc  agcctccag  acctgaaga  cttgcagta  tttgtttca  840
aagtggaac  acaggcaac  ccaaaggag  aatggtcac  caccgaaac  tagtgagcg  900
ttgttcagc  tttgtgaaa  caacagaga  tacagtcaa  ccttgccca  atgatactt  960
gatatcttt  ttgcctctc  cccatatgt  tgagagagt  gtagagtgt  taatgctgt  1020
tcatggagc  aaaatcgga  ttttccaag  agatatcag  ctgctcatg  atgacctca  1080
ggtgcttca  cccactgtc  tccccgtgg  tccaagact  ctgaaccgg  tgtttgacc  1140
aattttcgg  caagcaaac  ccacgctga  gcgatggct  ttggacttt  cctccaaga  1200
gaaagaagc  gagcttcgc  gcggcatca  cagaaacaa  agcctgtgg  accggctga  1260
cttccacaa  gtacagtcg  gcctgggcg  aagagtccg  ctgatggtg  caggagccg  1320
cccggtgtc  gccactgtg  tgacgttcc  cagagcagc  ctgggctgt  agttttatg  1380
aggatacgg  cagacagag  gcactgccg  gtgctgcct  accatgcct  gagactgga  1440
cgcaggcca  gttggggcc  cgatgccgt  caatttgat  aaacttgtt  atgtggaag  1500
aatgaatta  atggctgcc  agggcgagg  cgaggtgtg  gtgaaaggg  caaatgtat  1560
tcagggcta  ttgaaggac  cagcgaaaa  agcagaagc  ttggacaaa  acggctggt  1620
acacacagg  gacattgga  aatggttac  aaatggcac  ttgaaaatt  tcgaccgga  1680
aaagcacat  tttaagctg  cacaaggag  atacatagc  cctgaaaag  ttgaaaata  1740
ctacatgcg  agtgagcct  ttgctcagg  gtttgtcca  ggagaaagc  tgcaggcat  1800
tctcattgc  attgtggta  cagatgttg  gacattatg  tcctgggcc  aaaagagag  1860
atttgaagg  tcgtttgag  aactgtgca  aaataagga  gtcaaaaaa  ctatcctcg  1920
agatatggt  agacttggg  aggattctg  tctgaaacc  tttgaacag  tcaaaggca  1980
cacattgca  cctgaatta  tttctatcg  caatggcct  ctgactcca  caatgaagg  2040
gaaaaggcc  gagctgcgg  actatttca  gtcgcagat  gatgacctc  attccacta  2100
caaggttta  tgtgaagaa  aaagctcag  ggaaatggc  cagttccac  atctcttct  2160
ctgctgatg  ccttcatgt  gttaatttt  aatacagca  gtgtaggga  ggaagcgtt  2220
gtgtttgac  tgtccattc  gggttcttc  cataggaat  ctagaggaa  cagaacacc  2280
ccttacagt  acctcatgt  gcagaccat  tttatggta  tacacactt  ccaaaatga  2340
ccttaaaaa  tgtaaaggg  atactataa  tgtgctaag  tatttgaga  ttcctcagt  2400
taaaaagtg  gttttaaat  ttctgtctc  ctgcttttc  aatcaaggg  ttaggactt  2460
gctatctct  agatgtctg  tacttgctg  aaattctgc  gctgtctgc  gctctaaag  2520
gtacagtgc  ctagaggga  gtgttccct  taaaaataa  aacaactgt  ctggctgga  2580
aatctcaca  gcggaccag  gatcttttt  aatccctgc  actgtccct  ctcacaggc  2640
ttcacagaa  ccttctgat  cgtaagggt  acgaaactc  tgttcttct  cagtcccct  2700
tggtttctg  tggagcata  ggtttccag  aagcgggag  gcagatcca  ctcagaacc  2760
tgcagataa  gagcctctg  caaatgggt  ctcatcaga  cgcgtggat  ctctttcat  2820
gcagaatgc  cttggactc  gttctccag  cctgattcc  cgactccat  ctttttcag  2880
ggttattta  aaatctgcc  tagattcta  agtgaagac  agcatttca  gaaagagtt  2940
cctggatca  ccatgctca  ctgtgacgc  tgaataact  tctacttta  cttcactga  3000
ccactcact  tgtgtaaag  ccaacagat  tttaatgtg  ttttcatat  aaaagatca  3060
gttgggatt  acttgcctt  ttccccaaa  aataaactc  caggcaagc  tttctttaa  3120
gctattaag  gagtatata  ttgagtact  attgaaatg  acagtaata  gcaaatgtt  3180
ttataatgc  acctgattt  tatgaaatg  gtttgacaa  ccaaaattc  aggatgtag  3240
aatctggaa  gttcatttc  tgggattca  ttctccagg  attttttaa  gttaatttg  3300
gaaattaac  gcagttcac  ttattgtga  tctttgcca  atttgactg  attgagctg  3360
catttgtac  tttaaagca  ctgttttgg  gtctgtgag  gtacatgta  tatatacaa  3420
cacaacagg  cttgcacta  agaattgtc  ttgtaataa  actacttgg  agcctaact  3480
catatatgt  ttcttaatt  cacaaaaag  caataattt  tcaccttgg  gttttgaat  3540
tttgcttta  gtgttggct  tttctatgt  ttataaacc  aaacaaaat  tccaaaaac  3600
atgaaggaa  ccaaaataa  tatttctgc  tttc  3634



<210> 6674
<211> 698
<212> PRT
<213> Homo sapiens
<308> P33121
<400> 6674

Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val 
  1               5                  10                  15
Asp Phe Arg Gln Tyr Val Arg Thr Leu Pro Thr Asn Thr Leu Met Gly 
             20                  25                  30
Phe Gly Ala Phe Ala Ala Leu Thr Thr Phe Trp Tyr Ala Thr Arg Pro 
         35                  40                  45
Lys Pro Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val 
     50                  55                  60
Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu 
 65                  70                  75                  80
Pro Leu Val Tyr Phe Tyr Asp Asp Val Thr Thr Leu Tyr Glu Gly Phe 
                 85                  90                  95
Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg 
             100                105                110
Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Val Ala Glu 
         115                120                125
Leu Ser Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys Thr 
     130                135                140
Ala Pro Asp Gln Phe Ile Gly Ile Phe Ala Gln Asn Arg Pro Glu Trp 
 145                150                155                160
Val Ile Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro 
                 165                170                175
Leu Tyr Asp Thr Leu Gly Asn Glu Ala Ile Thr Tyr Ile Val Asn Lys 
             180                185                190
Ala Glu Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu 
         195                200                205
Leu Leu Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile 
     210                215                220
Val Val Met Asp Ala Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg 
 225                230                235                240
Cys Gly Val Glu Val Thr Ser Met Lys Ala Met Glu Asp Leu Gly Arg 
                 245                250                255
Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val 
             260                265                270
Ile Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Val 
         275                280                285
Thr His Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Thr 
     290                295                300
Glu Asn Thr Val Asn Pro Cys Pro Asp Asp Thr Leu Ile Ser Phe Leu 
 305                310                315                320
Pro Leu Ala His Met Phe Glu Arg Val Val Glu Cys Val Met Leu Cys 
                 325                330                335
His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met 
             340                345                350
Asp Asp Leu Lys Val Leu Gln Pro Thr Val Phe Pro Val Val Pro Arg 
         355                360                365
Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Thr Thr 
     370                375                380
Leu Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala Glu 
 385                390                395                400
Leu Arg Ser Gly Ile Ile Arg Asn Asn Ser Leu Trp Asp Arg Leu Ile 
                 405                410                415
Phe His Lys Val Gln Ser Ser Leu Gly Gly Arg Val Arg Leu Met Val 
             420                425                430
Thr Gly Ala Ala Pro Val Ser Ala Thr Val Leu Thr Phe Leu Arg Ala 
         435                440                445
Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr 
     450                455                460
Ala Gly Cys Cys Leu Thr Met Pro Gly Asp Trp Thr Ala Gly His Val 
 465                470                475                480
Gly Ala Pro Met Pro Cys Asn Leu Ile Lys Leu Val Asp Val Glu Glu 
                 485                490                495
Met Asn Tyr Met Ala Ala Glu Gly Glu Gly Glu Val Cys Val Lys Gly 
             500                505                510
Pro Asn Val Phe Gln Gly Tyr Leu Lys Asp Pro Ala Lys Thr Ala Glu 
         515                520                525
Ala Leu Asp Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys Trp 
     530                535                540
Leu Pro Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe 
 545                550                555                560
Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn Ile 
                 565                570                575
Tyr Met Arg Ser Glu Pro Val Ala Gln Val Phe Val His Gly Glu Ser 
             580                585                590
Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Thr Leu 
         595                600                605
Cys Ser Trp Ala Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu Leu 
     610                615                620
Cys Arg Asn Lys Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val Arg 
 625                630                635                640
Leu Gly Lys Asp Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly Ile 
                 645                650                655
Thr Leu His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Thr Pro 
             660                665                670
Thr Met Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser Gln 
         675                680                685
Ile Asp Asp Leu Tyr Ser Thr Ile Lys Val 
     690                695



<210> 6675
<211> 388
<212> DNA
<213> Rattus norvegicus
<308> AI044900
<400> 6675

ttttttttt  tttttttga  actgggtac  cgcattgtt  tgaggagga  ctgttcttt  60
gtgtactgg  aacacgagg  taccagcag  cacaacagg  accctttgg  acccttaca  120
accagaagg  tcacataaa  gtactgcat  tgaggtggt  agggaaagg  acaagggga  180
ggggttaag  agagaaatc  ctggtccac  gtgactttc  tcagcctgg  cagttgctc  240
taaaggggt  gctttcttc  agtgtactg  actcttcag  gcagcagac  gctgcaggg  300
gtgcagcca  cagcagacg  atcagaaag  gtaagtcct  accccttgg  tagaaaaac  360
ggagacaga  gttttaaca  ccacctta  388



<210> 6676
<211> 699
<212> PRT
<213> Rattus norvegicus
<308> P18163
<400> 6676

Met Glu Val His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Ile 
  1               5                  10                  15
Asp Ile Arg Gln Tyr Val Arg Thr Leu Pro Thr Asn Thr Leu Met Gly 
             20                  25                  30
Phe Gly Ala Phe Ala Ala Leu Thr Thr Phe Trp Tyr Ala Thr Arg Pro 
         35                  40                  45
Lys Ala Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val 
     50                  55                  60
Thr Gly Thr Thr Glu Gly Val Arg Arg Ser Ala Val Leu Glu Asp Asp 
 65                  70                  75                  80
Lys Leu Leu Leu Tyr Tyr Tyr Asp Asp Val Arg Thr Met Tyr Asp Gly 
                 85                  90                  95
Phe Gln Arg Gly Ile Gln Val Ser Asn Asp Gly Pro Cys Leu Gly Ser 
             100                105                110
Arg Lys Pro Asn Gln Pro Tyr Glu Trp Ile Ser Tyr Lys Gln Val Ala 
         115                120                125
Glu Met Ala Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys 
     130                135                140
Pro Cys Ser Glu Gln Phe Ile Gly Ile Phe Ser Gln Asn Arg Pro Glu 
 145                150                155                160
Trp Val Thr Ile Glu Gln Gly Cys Phe Thr Tyr Ser Met Val Val Val 
                 165                170                175
Pro Leu Tyr Asp Thr Leu Gly Thr Asp Ala Ile Thr Tyr Ile Val Asn 
             180                185                190
Lys Ala Glu Leu Ser Val Ile Phe Ala Asp Lys Pro Glu Lys Ala Lys 
         195                200                205
Leu Leu Leu Glu Gly Val Glu Asn Lys Leu Thr Pro Cys Leu Lys Ile 
     210                215                220
Ile Val Ile Met Asp Ser Tyr Asp Asn Asp Leu Val Glu Arg Gly Gln 
 225                230                235                240
Lys Cys Gly Val Glu Ile Ile Gly Leu Lys Ala Leu Glu Asp Leu Gly 
                 245                250                255
Arg Val Asn Arg Thr Lys Pro Lys Pro Pro Glu Pro Glu Asp Leu Ala 
             260                265                270
Ile Ile Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met 
         275                280                285
Val Thr His Gln Asn Ile Met Asn Asp Cys Ser Gly Phe Ile Lys Ala 
     290                295                300
Thr Glu Ser Ala Phe Ile Ala Ser Pro Glu Asp Val Leu Ile Ser Phe 
 305                310                315                320
Leu Pro Leu Ala His Met Phe Glu Thr Val Val Glu Cys Val Met Leu 
                 325                330                335
Cys His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu 
             340                345                350
Met Asp Asp Leu Lys Val Leu Gln Pro Thr Ile Phe Pro Val Val Pro 
         355                360                365
Arg Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Thr 
     370                375                380
Ser Val Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala 
 385                390                395                400
Glu Leu Arg Ser Gly Ile Val Arg Asn Asn Ser Leu Trp Asp Lys Leu 
                 405                410                415
Ile Phe His Lys Ile Gln Ser Ser Leu Gly Gly Lys Val Arg Leu Met 
             420                425                430
Ile Thr Gly Ala Ala Pro Val Ser Ala Thr Val Leu Thr Phe Leu Arg 
         435                440                445
Ala Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Thr Glu Cys 
     450                455                460
Thr Ala Gly Cys Cys Leu Ser Leu Pro Gly Asp Trp Thr Ala Gly His 
 465                470                475                480
Val Gly Ala Pro Met Pro Cys Asn Tyr Ile Lys Leu Val Asp Val Glu 
                 485                490                495
Asp Met Asn Tyr Gln Ala Ala Lys Gly Glu Gly Glu Val Cys Val Lys 
             500                505                510
Gly Ala Asn Val Phe Lys Gly Tyr Leu Lys Asp Pro Ala Arg Thr Ala 
         515                520                525
Glu Ala Leu Asp Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys 
     530                535                540
Trp Leu Pro Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile 
 545                550                555                560
Phe Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn 
                 565                570                575
Ile Tyr Leu Arg Ser Glu Ala Val Ala Gln Val Phe Val His Gly Glu 
             580                585                590
Ser Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Ile 
         595                600                605
Leu Pro Ser Trp Ala Gln Lys Arg Gly Phe Gln Gly Ser Phe Glu Glu 
     610                615                620
Leu Cys Arg Asn Lys Asp Ile Asn Lys Ala Ile Leu Glu Asp Met Val 
 625                630                635                640
Lys Leu Gly Lys Asn Ala Gly Leu Lys Pro Phe Glu Gln Val Lys Gly 
                 645                650                655
Ile Ala Val His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Thr 
             660                665                670
Pro Thr Leu Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser 
         675                680                685
Gln Ile Asp Glu Leu Tyr Ser Thr Ile Lys Ile 
     690                695



<210> 6677
<211> 3634
<212> DNA
<213> Homo sapiens
<308> D10040
<400> 6677

tcaacacag  acaatgcaa  cccatgagc  gttccggta  tttcgaatg  cagagctgg  60
tgacttccg  cagtacgtg  gtactcttc  gaccaacac  cttatgggc  tcggagctt  120
tgcagcact  accaccttc  ggtacgcca  gagacccaa  cccctgaag  cgccatgcg  180
cctctccat  cagtcagtg  aagtggcgg  tagtggtgg  gcacgaaga  ccgcactac  240
tgacagcga  gagcccttg  tgtatttct  tgatgatgt  acaacatta  acgaaggtt  300
ccagagggg  atacaggtg  caaataatg  cccttgttt  ggctctcgg  aaccagacc  360
accctatga  tggctttca  ataaacagg  tgcagaatt  tcggagtgc  taggctcag  420
actgatcca  aagggcttc  agactgccc  agatcagtt  attggcatc  ttgctcaaa  480
tagacctga  tgggtgatt  ttgaacaag  atgctttgc  tattcgatg  tgatcgttc  540
actttatga  acccttgga  atgaagcca  cacgtacat  gtcaacaaa  ctgaactct  600
tctggtttt  gttgacaag  cagagaagg  caaactctt  ttagagggt  tagaaaata  660
gttaatacc  ggccttaaa  tcatagttg  catggatgc  tacggcagt  aactggtgg  720
acgaggcca  aggtgtggg  tggaagtca  cagcatgaa  gcgatggag  acctgggaa  780
agccaacag  cggaagccc  agcctccag  acctgaaga  cttgcagta  tttgtttca  840
aagtggaac  acaggcaac  ccaaaggag  aatggtcac  caccgaaac  tagtgagcg  900
ttgttcagc  tttgtgaaa  caacagaga  tacagtcaa  ccttgccca  atgatactt  960
gatatcttt  ttgcctctc  cccatatgt  tgagagagt  gtagagtgt  taatgctgt  1020
tcatggagc  aaaatcgga  ttttccaag  agatatcag  ctgctcatg  atgacctca  1080
ggtgcttca  cccactgtc  tccccgtgg  tccaagact  ctgaaccgg  tgtttgacc  1140
aattttcgg  caagcaaac  ccacgctga  gcgatggct  ttggacttt  cctccaaga  1200
gaaagaagc  gagcttcgc  gcggcatca  cagaaacaa  agcctgtgg  accggctga  1260
cttccacaa  gtacagtcg  gcctgggcg  aagagtccg  ctgatggtg  caggagccg  1320
cccggtgtc  gccactgtg  tgacgttcc  cagagcagc  ctgggctgt  agttttatg  1380
aggatacgg  cagacagag  gcactgccg  gtgctgcct  accatgcct  gagactgga  1440
cgcaggcca  gttggggcc  cgatgccgt  caatttgat  aaacttgtt  atgtggaag  1500
aatgaatta  atggctgcc  agggcgagg  cgaggtgtg  gtgaaaggg  caaatgtat  1560
tcagggcta  ttgaaggac  cagcgaaaa  agcagaagc  ttggacaaa  acggctggt  1620
acacacagg  gacattgga  aatggttac  aaatggcac  ttgaaaatt  tcgaccgga  1680
aaagcacat  tttaagctg  cacaaggag  atacatagc  cctgaaaag  ttgaaaata  1740
ctacatgcg  agtgagcct  ttgctcagg  gtttgtcca  ggagaaagc  tgcaggcat  1800
tctcattgc  attgtggta  cagatgttg  gacattatg  tcctgggcc  aaaagagag  1860
atttgaagg  tcgtttgag  aactgtgca  aaataagga  gtcaaaaaa  ctatcctcg  1920
agatatggt  agacttggg  aggattctg  tctgaaacc  tttgaacag  tcaaaggca  1980
cacattgca  cctgaatta  tttctatcg  caatggcct  ctgactcca  caatgaagg  2040
gaaaaggcc  gagctgcgg  actatttca  gtcgcagat  gatgacctc  attccacta  2100
caaggttta  tgtgaagaa  aaagctcag  ggaaatggc  cagttccac  atctcttct  2160
ctgctgatg  ccttcatgt  gttaatttt  aatacagca  gtgtaggga  ggaagcgtt  2220
gtgtttgac  tgtccattc  gggttcttc  cataggaat  ctagaggaa  cagaacacc  2280
ccttacagt  acctcatgt  gcagaccat  tttatggta  tacacactt  ccaaaatga  2340
ccttaaaaa  tgtaaaggg  atactataa  tgtgctaag  tatttgaga  ttcctcagt  2400
taaaaagtg  gttttaaat  ttctgtctc  ctgcttttc  aatcaaggg  ttaggactt  2460
gctatctct  agatgtctg  tacttgctg  aaattctgc  gctgtctgc  gctctaaag  2520
gtacagtgc  ctagaggga  gtgttccct  taaaaataa  aacaactgt  ctggctgga  2580
aatctcaca  gcggaccag  gatcttttt  aatccctgc  actgtccct  ctcacaggc  2640
ttcacagaa  ccttctgat  cgtaagggt  acgaaactc  tgttcttct  cagtcccct  2700
tggtttctg  tggagcata  ggtttccag  aagcgggag  gcagatcca  ctcagaacc  2760
tgcagataa  gagcctctg  caaatgggt  ctcatcaga  cgcgtggat  ctctttcat  2820
gcagaatgc  cttggactc  gttctccag  cctgattcc  cgactccat  ctttttcag  2880
ggttattta  aaatctgcc  tagattcta  agtgaagac  agcatttca  gaaagagtt  2940
cctggatca  ccatgctca  ctgtgacgc  tgaataact  tctacttta  cttcactga  3000
ccactcact  tgtgtaaag  ccaacagat  tttaatgtg  ttttcatat  aaaagatca  3060
gttgggatt  acttgcctt  ttccccaaa  aataaactc  caggcaagc  tttctttaa  3120
gctattaag  gagtatata  ttgagtact  attgaaatg  acagtaata  gcaaatgtt  3180
ttataatgc  acctgattt  tatgaaatg  gtttgacaa  ccaaaattc  aggatgtag  3240
aatctggaa  gttcatttc  tgggattca  ttctccagg  attttttaa  gttaatttg  3300
gaaattaac  gcagttcac  ttattgtga  tctttgcca  atttgactg  attgagctg  3360
catttgtac  tttaaagca  ctgttttgg  gtctgtgag  gtacatgta  tatatacaa  3420
cacaacagg  cttgcacta  agaattgtc  ttgtaataa  actacttgg  agcctaact  3480
catatatgt  ttcttaatt  cacaaaaag  caataattt  tcaccttgg  gttttgaat  3540
tttgcttta  gtgttggct  tttctatgt  ttataaacc  aaacaaaat  tccaaaaac  3600
atgaaggaa  ccaaaataa  tatttctgc  tttc  3634



<210> 6678
<211> 698
<212> PRT
<213> Homo sapiens
<308> P33121
<400> 6678

Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val 
  1               5                  10                  15
Asp Phe Arg Gln Tyr Val Arg Thr Leu Pro Thr Asn Thr Leu Met Gly 
             20                  25                  30
Phe Gly Ala Phe Ala Ala Leu Thr Thr Phe Trp Tyr Ala Thr Arg Pro 
         35                  40                  45
Lys Pro Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val 
     50                  55                  60
Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu 
 65                  70                  75                  80
Pro Leu Val Tyr Phe Tyr Asp Asp Val Thr Thr Leu Tyr Glu Gly Phe 
                 85                  90                  95
Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg 
             100                105                110
Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Val Ala Glu 
         115                120                125
Leu Ser Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys Thr 
     130                135                140
Ala Pro Asp Gln Phe Ile Gly Ile Phe Ala Gln Asn Arg Pro Glu Trp 
 145                150                155                160
Val Ile Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro 
                 165                170                175
Leu Tyr Asp Thr Leu Gly Asn Glu Ala Ile Thr Tyr Ile Val Asn Lys 
             180                185                190
Ala Glu Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu 
         195                200                205
Leu Leu Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile 
     210                215                220
Val Val Met Asp Ala Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg 
 225                230                235                240
Cys Gly Val Glu Val Thr Ser Met Lys Ala Met Glu Asp Leu Gly Arg 
                 245                250                255
Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val 
             260                265                270
Ile Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Val 
         275                280                285
Thr His Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Thr 
     290                295                300
Glu Asn Thr Val Asn Pro Cys Pro Asp Asp Thr Leu Ile Ser Phe Leu 
 305                310                315                320
Pro Leu Ala His Met Phe Glu Arg Val Val Glu Cys Val Met Leu Cys 
                 325                330                335
His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met 
             340                345                350
Asp Asp Leu Lys Val Leu Gln Pro Thr Val Phe Pro Val Val Pro Arg 
         355                360                365
Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Thr Thr 
     370                375                380
Leu Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala Glu 
 385                390                395                400
Leu Arg Ser Gly Ile Ile Arg Asn Asn Ser Leu Trp Asp Arg Leu Ile 
                 405                410                415
Phe His Lys Val Gln Ser Ser Leu Gly Gly Arg Val Arg Leu Met Val 
             420                425                430
Thr Gly Ala Ala Pro Val Ser Ala Thr Val Leu Thr Phe Leu Arg Ala 
         435                440                445
Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr 
     450                455                460
Ala Gly Cys Cys Leu Thr Met Pro Gly Asp Trp Thr Ala Gly His Val 
 465                470                475                480
Gly Ala Pro Met Pro Cys Asn Leu Ile Lys Leu Val Asp Val Glu Glu 
                 485                490                495
Met Asn Tyr Met Ala Ala Glu Gly Glu Gly Glu Val Cys Val Lys Gly 
             500                505                510
Pro Asn Val Phe Gln Gly Tyr Leu Lys Asp Pro Ala Lys Thr Ala Glu 
         515                520                525
Ala Leu Asp Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys Trp 
     530                535                540
Leu Pro Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe 
 545                550                555                560
Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn Ile 
                 565                570                575
Tyr Met Arg Ser Glu Pro Val Ala Gln Val Phe Val His Gly Glu Ser 
             580                585                590
Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Thr Leu 
         595                600                605
Cys Ser Trp Ala Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu Leu 
     610                615                620
Cys Arg Asn Lys Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val Arg 
 625                630                635                640
Leu Gly Lys Asp Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly Ile 
                 645                650                655
Thr Leu His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Thr Pro 
             660                665                670
Thr Met Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser Gln 
         675                680                685
Ile Asp Asp Leu Tyr Ser Thr Ile Lys Val 
     690                695



<210> 6679
<211> 392
<212> DNA
<213> Rattus norvegicus
<308> AI059291
<400> 6679

taagcttgc  gccgccggc  gccccgacc  gccggccct  tcagcggtc  ccggcatga  60
ccacatcca  atcccaccg  ggctcacgg  gctgctgca  ggctacacc  tggaggtgc  120
tcggcagca  ccgcccgac  tcgtcgact  cgcggtgga  tacttcaca  gcctgcgcg  180
ggcccgccg  caggaatca  actcgttca  cgccccccc  acgaccttt  acgcgcagg  240
gtccagcgg  gtctccgtc  tcgaggagg  cggggagag  gaatcggac  cggacgatg  300
ggatctgga  gttccgatt  ccagcaaat  tactagacg  gtatcagtc  gtgcagaaa  360
gtttaaccc  gatgaagaa  cctcgtgcc  aa  392



<210> 6680
<211> 370
<212> PRT
<213> Rattus norvegicus
<308> P12368
<400> 6680

Phe Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Arg Gln Glu 
  1               5                  10                  15
Ser Asp Ser Phe Ile Ala Pro Pro Thr Thr Phe His Ala Gln Glu Ser 
             20                  25                  30
Ser Gly Val Pro Val Ile Glu Glu Asp Gly Gln Ser Glu Ser Asp Ser 
         35                  40                  45
Asp Asp Glu Asp Leu Glu Val Pro Ile Pro Ala Lys Phe Thr Arg Arg 
     50                  55                  60
Val Ser Val Cys Ala Glu Thr Phe Asn Pro Asp Glu Glu Glu Asp Asn 
 65                  70                  75                  80
Asp Pro Arg Val Val His Pro Lys Thr Asp Glu Gln Arg Cys Arg Leu 
                 85                  90                  95
Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Gln Glu 
             100                105                110
Gln Leu Ser Gln Val Leu Asp Ala Met Phe Lys Arg Ile Val Lys Thr 
         115                120                125
Asp Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr Val 
     130                135                140
Ile Glu Arg Gly Thr Tyr Asp Ile Leu Val Thr Lys Asp Asn Gln Thr 
 145                150                155                160
Arg Ser Val Gly Gln Tyr Ala Asn Arg Gly Ser Phe Gly Glu Leu Ala 
                 165                170                175
Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Val Ala Thr Ser Asp 
             180                185                190
Gly Ser Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile Val 
         195                200                205
Lys Asn Asn Ala Lys Lys Arg Lys Met Phe Glu Ser Phe Ile Glu Ser 
     210                215                220
Val Pro Leu Phe Lys Ser Leu Glu Met Ser Glu Arg Met Lys Ile Val 
 225                230                235                240
Asp Val Ile Gly Glu Lys Ile Tyr Lys Asp Gly Glu Arg Ile Ile Thr 
                 245                250                255
Gln Gly Glu Lys Ala Asp Ser Phe Tyr Ile Ile Glu Ser Gly Glu Val 
             260                265                270
Ser Ile Leu Ile Arg Ser Lys Thr Lys Thr Asn Lys Asn Gly Gly Asn 
         275                280                285
Gln Glu Val Glu Ile Ala His Cys His Lys Gly Gln Tyr Phe Gly Glu 
     290                295                300
Leu Ala Leu Val Thr Asn Lys Pro Arg Ala Ala Ser Ala Tyr Ala Val 
 305                310                315                320
Gly Asp Val Lys Cys Leu Val Met Asp Val Gln Ala Phe Glu Arg Leu 
                 325                330                335
Leu Gly Pro Cys Met Asp Ile Met Lys Arg Asn Ile Ser His Tyr Glu 
             340                345                350
Glu Gln Leu Val Lys Met Phe Gly Ser Asn Leu Asp Leu Leu Asp Pro 
         355                360                365
Gly Gln 
     370



<210> 6681
<211> 1743
<212> DNA
<213> Homo sapiens
<308> X14968
<400> 6681

ccaggtcgg  cgtggtagc  tagggttgc  cggcccgga  acgcagagc  ggccaaaga  60
cggcgcgac  tgagccggg  ccgtgcgcg  agagacctc  cgggcgcgg  gcgaaaggc  120
ggcgtgagt  agcgcggag  cagtggccg  cggcggccc  acccgtcta  cccttcggc  180
gccgccggc  tgagccaca  ccagatccc  ccggggctc  cggagctgc  gcagggcta  240
acggtggag  tgctgcgac  gcagccgcc  gacctcgtc  aattcgcag  ggagtactt  300
acccgcctg  gcgaggccc  cgccccagc  tcagtcctg  ccgccgcca  cccacgcca  360
agcctgggc  accccccgc  agaacccgg  ccggaccgt  tcgccgacg  caaagggga  420
agcgagtcg  aggaggacg  ggacttgga  gttccagtt  ctagcagat  taatagacg  480
gtatcagtc  gtgctgaga  ctataaccc  gatgaggaa  aggaagata  agatccaag  540
gtgattcat  ctaaaactg  tgaacagag  tgcagactt  aggaagctt  caaagatat  600
ctccttttc  aaaatcttg  tcaggaaca  ctttctcaa  ttctcgatg  catgtttga  660
aggatagtc  aagctgatg  gcatgtcat  gaccaagga  atgatggag  caactttta  720
gtcatagaa  ggggaactt  tgacatttt  gtaacaaaa  ataatcaaa  ccgctctgt  780
ggtcaatat  acaaccgtg  cagttttgg  gaactagct  tgatgtaca  caccccgag  840
gctgctacc  ttgttgcta  ctcagaagg  tccctttgg  gactggacc  ggtgacttt  900
agaagaatc  tagtgaaaa  taatgcaaa  aagaggaag  tgtttgaat  atttattga  960
tctgtgccc  tccttaaat  actagaggt  tcagaacga  tgaagattg  ggatgtaat  1020
ggagagaag  tctataagg  tggagaacg  ataatcact  agggtgaaa  ggctgatag  1080
ttttacatc  tagagtctg  cgaagtgag  atcttgatt  gaagcagga  taaatcaaa  1140
aaggatggt  ggaaccagg  ggtcgagat  gcccgctgc  ataaggggc  gtactttgg  1200
gagcttgcc  tggtcacca  caaacccag  gctgcctca  cttatgcag  tggagatgt  1260
aaatgctta  ttatggatg  acaagcatt  gagaggctt  tggggccct  catggacat  1320
atgaagagg  acatctcac  ctatgagga  cagctggtg  agatgtttg  ctccagcgt  1380
gatctgggc  acctcgggc  gtaggtgtg  cacacccca  agccttctt  gtgtgacac  1440
aaaaccttc  ggtcagcca  agaacacat  cagaaaaca  acatgacag  actgttcct  1500
ccgttgccg  cactgctgc  attgctgtg  ttatgggca  ttagaaaac  tgaaagtca  1560
cactaaagg  tgggcagag  ttcaaccca  acctccact  tgcttctga  ggcccattc  1620
ttagaccac  tgtaaagat  actccaacc  agtttttat  tctttggtt  aaaacggca  1680
gtctctcca  caatttaag  gcctgatac  aagtccaaa  tataaacat  ctcctttcc  1740
ctc  1743



<210> 6682
<211> 403
<212> PRT
<213> Homo sapiens
<308> P13861
<400> 6682

Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
  1               5                  10                  15
Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
             20                  25                  30
Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala Pro Ala Ser Val 
         35                  40                  45
Leu Pro Ala Ala Thr Pro Arg Gln Ser Leu Gly His Pro Pro Pro Glu 
     50                  55                  60
Pro Gly Pro Asp Arg Val Ala Asp Ala Lys Gly Asp Ser Glu Ser Glu 
 65                  70                  75                  80
Glu Asp Glu Asp Leu Glu Val Pro Val Pro Ser Arg Phe Asn Arg Arg 
                 85                  90                  95
Val Ser Val Cys Ala Glu Thr Tyr Asn Pro Asp Glu Glu Glu Glu Asp 
             100                105                110
Thr Asp Pro Arg Val Ile His Pro Lys Thr Asp Glu Gln Arg Cys Arg 
         115                120                125
Leu Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Gln 
     130                135                140
Glu Gln Leu Ser Gln Val Leu Asp Ala Met Phe Glu Arg Ile Val Lys 
 145                150                155                160
Ala Asp Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr 
                 165                170                175
Val Ile Glu Arg Gly Thr Tyr Asp Ile Leu Val Thr Lys Asp Asn Gln 
             180                185                190
Thr Arg Ser Val Gly Gln Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu 
         195                200                205
Ala Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Val Ala Thr Ser 
     210                215                220
Glu Gly Ser Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile 
 225                230                235                240
Val Lys Asn Asn Ala Lys Lys Arg Lys Met Phe Glu Ser Phe Ile Glu 
                 245                250                255
Ser Val Pro Leu Leu Lys Ser Leu Glu Val Ser Glu Arg Met Lys Ile 
             260                265                270
Val Asp Val Ile Gly Glu Lys Ile Tyr Lys Asp Gly Glu Arg Ile Ile 
         275                280                285
Thr Gln Gly Glu Lys Ala Asp Ser Phe Tyr Ile Ile Glu Ser Gly Glu 
     290                295                300
Val Ser Ile Leu Ile Arg Ser Arg Thr Lys Ser Asn Lys Asp Gly Gly 
 305                310                315                320
Asn Gln Glu Val Glu Ile Ala Arg Cys His Lys Gly Gln Tyr Phe Gly 
                 325                330                335
Glu Leu Ala Leu Val Thr Asn Lys Pro Arg Ala Ala Ser Ala Tyr Ala 
             340                345                350
Val Gly Asp Val Lys Cys Leu Val Met Asp Val Gln Ala Phe Glu Arg 
         355                360                365
Leu Leu Gly Pro Cys Met Asp Ile Met Lys Arg Asn Ile Ser His Tyr 
     370                375                380
Glu Glu Gln Leu Val Lys Met Phe Gly Ser Ser Val Asp Leu Gly Asn 
 385                390                395                400
Leu Gly Gln 
                 405



<210> 6683
<211> 529
<212> DNA
<213> Rattus norvegicus
<308> AI070108
<400> 6683

ttttttttt  tttttttgg  attttattg  tttttattc  tgaagtaga  cttttactt  60
atcccagcg  tttcctcag  ggtagactt  gatttgatt  caatgagtt  ttcgactcg  120
gccaggaca  tttcaatca  gtcgaatgt  aagagggcg  aatgtaaga  cttaagctg  180
atctcagga  gcatagtgg  gatttcttc  ccgcctaca  tcacagaac  aacactttt  240
cacattgag  cagcttggc  attttgttg  ctgttttta  tctctgctt  ataatgtgc  300
tttgacata  taagtccta  atgaagtgg  tgtagaaag  tattttcaa  ctttccaag  360
tctgtccat  atccagttt  gttgtcatc  tcattatct  tgataacca  atacctcaa  420
aaatttagt  aagccataa  ccggtctga  ttctgcagt  aatctgtct  agcgccctc  480
gggagggac  ggaccaggt  taacagaga  gtcagctgt  cgcctgcaa  529



<210> 6684
<211> 596
<212> PRT
<213> Rattus norvegicus
<308> AAH03446
<400> 6684

Met Ala Val Glu Glu Leu Gln Ser Ile Ile Lys Arg Cys Gln Ile Leu 
  1               5                  10                  15
Glu Glu His Asp Phe Lys Glu Glu Asp Phe Gly Leu Phe Gln Leu Ala 
             20                  25                  30
Gly Gln Arg Cys Ile Glu Asp Gly Tyr Ile Asn Gln Leu Leu Glu Ile 
         35                  40                  45
Ile Gln Asp Glu Lys Asn Lys Thr Ile Ile Lys Ser Met Gly Trp Asn 
     50                  55                  60
Leu Val Gly Pro Val Val Arg Cys Leu Leu Arg Gly Arg Glu Glu Asp 
 65                  70                  75                  80
Lys Arg Glu Glu Cys Phe Leu Ile Phe Asp Leu Leu Val Lys Leu Cys 
                 85                  90                  95
Asn Pro Lys Glu Leu Leu Leu Gly Leu Leu Glu Leu Ile Glu Glu Pro 
             100                105                110
Ser Gly Lys Gln Ile Ser Gln Ile Ile Leu Leu Leu Leu Gln Pro Leu 
         115                120                125
Gln Thr Val Ile Gln Lys Leu Pro Asn Asn Lys Ala Tyr Ser Val Gly 
     130                135                140
Leu Ala Leu Ser Thr Leu Trp Ser Gln Leu Ser Leu Leu Pro Val Pro 
 145                150                155                160
His Ser Glu Glu Gln Ile Gln Ala Asp Asp Tyr Gly Leu Cys Gln Cys 
                 165                170                175
Cys Lys Ala Leu Ile Glu Phe Thr Lys Pro Phe Val Glu Glu Val Ile 
             180                185                190
Ser Asp Lys Glu Asn Lys Glu Asn Ala Lys Leu Lys Asp Glu Leu Leu 
         195                200                205
Lys Phe Cys Phe Lys Gly Leu Lys Cys Pro Leu Leu Thr Ala Gln Phe 
     210                215                220
Leu Glu Gln Ser Glu Asp Val Gly Asn Asp Pro Phe Arg Cys Phe Ala 
 225                230                235                240
Ser Glu Ile Ile Gly Phe Leu Ser Lys Ile Gly His Pro Val Pro Gln 
                 245                250                255
Ile Ile Leu Asn His Gly Arg Lys Lys Arg Thr Trp Asp Ser Leu Glu 
             260                265                270
Phe Glu Glu Glu Glu Asp Lys Gln Leu Ala Glu Ser Val Ala Ser Leu 
         275                280                285
Thr Tyr Leu Val Phe Val Gln Gly Ile Gly Ile Asp Gln Leu Pro Met 
     290                295                300
Val Leu Ser Pro Ser Tyr Leu Leu Gln Leu Asn Met Glu His Ile Glu 
 305                310                315                320
Val Phe Leu Gln Arg Thr Glu Gln Ser Ile Tyr Ser Lys Gly Leu Glu 
                 325                330                335
Leu Leu Glu Thr Ser Leu Leu Arg Leu Glu Asp Asn Ser Leu Cys Tyr 
             340                345                350
Gln Tyr Leu Glu Ile Lys Ser Phe Leu Ala Val Pro Gln Gly Leu Val 
         355                360                365
Lys Val Met Thr Leu Cys Pro Ile Glu Thr Leu Arg Lys Lys Gly Leu 
     370                375                380
Ser Met Leu Gln Leu Phe Ile Asp Lys Leu Asp Ser Gln Gly Lys Tyr 
 385                390                395                400
Thr Leu Phe Arg Cys Leu Leu Asn Thr Ser Asn His Ser Gly Val Glu 
                 405                410                415
Ala Phe Val Ile Gln Asn Ile Lys Asn Gln Ile Asp Leu Ser Phe Lys 
             420                425                430
Lys Thr Tyr Asn Lys Trp Phe Ala Gly Ala Gln Leu Ile Ser Leu Leu 
         435                440                445
Asp Leu Val Leu Ser Leu Pro Glu Gly Ala Glu Thr Asp Leu Leu Gln 
     450                455                460
Asn Ser Asp Arg Ile Met Ala Ser Leu Asn Leu Leu Arg Tyr Leu Val 
 465                470                475                480
Ile Lys Asp Asn Glu Asp Asp Asn Gln Thr Gly Leu Trp Thr Glu Leu 
                 485                490                495
Gly Lys Ile Glu Asn Asn Phe Leu Lys Pro Leu His Ile Gly Leu Asn 
             500                505                510
Met Ser Lys Ala His Tyr Glu Ala Glu Ile Lys Asn Ser Gln Gln Asn 
         515                520                525
Asn Gln Val Ala Ser Met Cys Lys Gly Val Cys Ser Val Thr Val Gly 
     530                535                540
Gly Glu Glu Ile Pro Ser Met Pro Pro Glu Met Gln Leu Lys Val Leu 
 545                550                555                560
His Ser Ala Leu Phe Thr Phe Asp Leu Ile Glu Ser Val Leu Ala Arg 
                 565                570                575
Val Glu Glu Leu Ile Glu Ile Lys Ser Lys Ser Thr Ser Glu Glu Asn 
             580                585                590
Val Gly Ile Lys 
         595



<210> 6685
<211> 1833
<212> DNA
<213> Homo sapiens
<308> NM_007070
<400> 6685

agaagagcg  gctaagacg  cggaggagg  ggcggcggc  gggagaggc  agggttctg  60
ccgatttta  catcgaaac  aggagaaat  agaatggct  tagaggaac  tcagtctat  120
ataaagaga  gtcaaatcc  agaagagca  gactttaaa  aagaggatt  tggcctatt  180
cagttagct  ggcaaagat  catagaaga  gggcacaca  accagctat  agaaattat  240
caaaatgaa  agaataagg  catcatcaa  aatatgggc  ggaatctcg  tggtcctgt  300
gttcgatgc  ttttgtgta  agataaaga  gatagtaaa  gaaaagttt  ttttttgat  360
tttgattta  tggtaaagt  atgcaatcc  aaggaatta  tgttgggtt  gcttgaact  420
attgaagag  cctctggaa  acagatatc  caaagtatt  ttcttttgc  tcagccatt  480
caaacagtg  ttcagaaac  tcataacaa  gcatattca  ttggattag  attgtctac  540
ctttggaat  agctatctc  tcttcctgt  ccatactca  aagaacaaa  acaaatgga  600
gactatggc  tttgtcagt  ttgcaaggc  ttaatagag  tcactaagc  ttttgtgga  660
gaagtcatt  ataacaaag  aaactcact  gaaaatgaa  agttaaagg  tgaattact  720
aaattttgt  tcaaaagct  gaaatgccc  ttgctgaca  cacaattct  tgaacagtc  780
gaagaaggt  gaaatgatc  tttcaggta  tttgcatca  aaataatag  ttttttatc  840
gcaattgga  accctttcc  caaaatgat  tttaatcat  gaaggaaaa  gagaacttg  900
aattacctt  aatttgaag  agaagaaaa  aaacagtta  cagactcaa  ggcttctct  960
gcatatcta  tatttgtac  gggcatcca  attgatcag  ttccaatgg  cttaagccc  1020
ttgtacctt  tgcagttta  tatggggca  attgaagtc  ttttgcaaa  aacagaaga  1080
tctgttatc  ccaaaggat  ggagctgct  gagaatagt  tattgagaa  agaagacaa  1140
agtctactt  accagtact  agaaatcaa  agttttctt  ctgtacctc  gggcttagt  1200
aaagtaatg  cactttgcc  cattgagac  ctgaggaaa  agagtttag  tatgcttca  1260
ctgtatatt  acaagttgg  ttcacaagg  aaatataca  tatttagag  acacgtaac  1320
acaaatggt  tacaggacc  cagttgatt  cccttcttg  tttggtact  tttctccca  1380
agggtgcag  aacagattt  ctgcaaaac  cagatagga  tatggcttc  ttaaattta  1440
tgaggtatt  ggttatcaa  gataatgaa  atgacaatc  aactggatt  tggacagaa  1500
ttggaaata  tgagaataa  ttcttaaag  cacttcata  aggacttaa  atgtcaaaa  1560
cacattatg  agcagaaat  aaaaatagc  aagaggccc  gaaatctaa  gatctttgt  1620
ctataactg  aagtggaga  gagatccct  atatgcctc  tgaaatgca  cttaaggtc  1680
tgcattcag  tcttttcac  tttgatttg  ttgaaagtg  tctagctcg  gtggaagaa  1740
tcattgaaa  aaaaacaaa  tctacctct  aagaaaata  tgggataaa  tgaaagttc  1800
atttcctaa  taaaaacta  taaaatata  tac  1833



<210> 6686
<211> 417
<212> PRT
<213> Homo sapiens
<308> Q92990
<400> 6686

Met Ala Val Glu Glu Leu Gln Ser Ile Ile Lys Arg Cys Gln Ile Leu 
  1               5                  10                  15
Glu Glu Gln Asp Phe Lys Glu Glu Asp Phe Gly Leu Phe Gln Leu Ala 
             20                  25                  30
Gly Gln Arg Cys Ile Glu Glu Gly His Thr Asp Gln Leu Leu Glu Ile 
         35                  40                  45
Ile Gln Asn Glu Lys Asn Lys Val Ile Ile Lys Asn Met Gly Trp Asn 
     50                  55                  60
Leu Val Gly Pro Val Val Arg Cys Leu Leu Cys Lys Asp Lys Glu Asp 
 65                  70                  75                  80
Ser Lys Arg Lys Val Tyr Phe Leu Ile Phe Asp Leu Leu Val Lys Leu 
                 85                  90                  95
Cys Asn Pro Lys Glu Leu Leu Leu Gly Leu Leu Glu Leu Ile Glu Glu 
             100                105                110
Pro Ser Gly Lys Gln Ile Ser Gln Ser Ile Leu Leu Leu Leu Gln Pro 
         115                120                125
Leu Gln Thr Val Ile Gln Lys Leu His Asn Lys Ala Tyr Ser Ile Gly 
     130                135                140
Leu Ala Leu Ser Thr Leu Trp Asn Gln Leu Ser Leu Leu Pro Val Pro 
 145                150                155                160
Tyr Ser Lys Glu Gln Ile Gln Met Asp Asp Tyr Gly Leu Cys Gln Cys 
                 165                170                175
Cys Lys Ala Leu Ile Glu Phe Thr Lys Pro Phe Val Glu Glu Val Ile 
             180                185                190
Asp Asn Lys Glu Asn Ser Leu Glu Asn Glu Lys Leu Lys Asp Glu Leu 
         195                200                205
Leu Lys Phe Cys Phe Lys Ser Leu Lys Cys Pro Leu Leu Thr Ala Gln 
     210                215                220
Phe Phe Glu Gln Ser Glu Glu Gly Gly Asn Asp Pro Phe Arg Tyr Phe 
 225                230                235                240
Ala Ser Glu Ile Ile Gly Phe Leu Ser Ala Ile Gly His Pro Phe Pro 
                 245                250                255
Lys Met Ile Phe Asn His Gly Arg Lys Lys Arg Thr Trp Asn Tyr Leu 
             260                265                270
Glu Phe Glu Glu Glu Glu Asn Lys Gln Leu Ala Asp Ser Met Ala Ser 
         275                280                285
Leu Ala Tyr Leu Val Phe Val Gln Gly Ile His Ile Asp Gln Leu Pro 
     290                295                300
Met Val Leu Ser Pro Leu Tyr Leu Leu Gln Phe Asn Met Gly His Ile 
 305                310                315                320
Glu Val Phe Leu Gln Arg Thr Glu Glu Ser Val Ile Ser Lys Gly Leu 
                 325                330                335
Glu Leu Leu Glu Asn Ser Leu Leu Arg Ile Glu Asp Asn Ser Leu Leu 
             340                345                350
Tyr Gln Tyr Leu Glu Ile Lys Ser Phe Leu Thr Val Pro Gln Gly Leu 
         355                360                365
Val Lys Val Met Thr Leu Cys Pro Ile Glu Thr Leu Arg Lys Lys Ser 
     370                375                380
Leu Ala Met Leu Gln Leu Tyr Ile Asn Lys Leu Asp Ser Gln Gly Lys 
 385                390                395                400
Tyr Thr Leu Phe Arg Glu His Val Thr Thr Asn Gly Leu Gln Asp His 
                 405                410                415
Ser 
             420



<210> 6687
<211> 545
<212> DNA
<213> Rattus norvegicus
<308> AI070295
<400> 6687

ttttttttt  tttttttgt  attccatac  agtttattt  agataatgt  cttcaaaaa  60
gttttatca  aaataacct  tcacatcat  aaataactt  gtacgattt  taataaaac  120
tctgagaat  taacatctc  tcaaaatac  ttaaactgt  gcttgaaaa  atgattaac  180
cttttcact  ttcttttat  tgagggcat  aagaccaaa  aaaataccc  aaatattgc  240
acacattta  agtttcaac  aagcaatat  tggtttact  tactgtaac  cggccatcc  300
aaattaata  ttttctttc  tgcacagtt  tttgtagtt  ttttgtccc  tttgacttg  360
atttctgtt  ccacacagc  tcctccttc  gtctcacct  tctctcctt  tgcaaagtc  420
tctcctagc  ctcctgtag  tgaactcag  cccttgaca  cagtttctg  aatccttgc  480
tcagcgtgg  gagtgactg  ttgagtaac  acaaaggta  ttcaaaact  cagtgcaat  540
tggtt  545



<210> 6688
<211> 165
<212> PRT
<213> Rattus norvegicus
<308> P48317
<400> 6688

Met Thr Leu Glu Glu Phe Ser Ala Ala Glu Gln Lys Ile Glu Arg Met 
  1               5                  10                  15
Asp Thr Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Arg Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Arg Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Asn Asp Lys Ser Pro Ala Glu 
             100                105                110
Ser Gly Gly Leu Ala Gln Thr Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 6689
<211> 1343
<212> DNA
<213> Homo sapiens
<308> M60974
<400> 6689

ggcagtggc  gggaggcag  ggcccaatt  gtgtcgtgc  gcccgtggc  aggcgaggt  60
cggggagcg  gcgagcaag  aaggcggga  gggtggccg  agctgcggc  gctggcaca  120
gaggaggag  ccgggcggg  gaggggcgg  cggagagcg  cagggcctg  gctgccgga  180
cggcgcctg  gagtgagtg  agaaagcag  cgcccgcgc  ctagccgtg  caggagcag  240
ccgcacgcc  cgctctctc  ctgggcgac  tgcagtttg  aatatgact  tggaggaat  300
ctcggctgg  gagcagaag  ccgaaagga  ggataaggt  ggggatgcc  tggaggaag  360
gctcagcaa  gccctgagt  agcgcacga  cactgtcgg  gtgtacgaa  cggccaagc  420
gctcaacgt  gaccccgat  acgtggtgt  gtgcctgct  gcggcggac  aggacgacg  480
cagagatgt  gctctgcag  tccacttca  cctgatcca  gcgttttgc  gcgagaacg  540
catcaacat  ctgcgcgtc  gcaacccgg  ccggctggc  gagctcctg  tcttggaga  600
cgacgctgg  cccgcggcg  gcgagggcg  cgagcagcc  ccggacctg  actgcgtgc  660
ggtgacgaa  ccacattca  ctcaatgga  ggatcctgc  ttaagtcaa  ttatttgtt  720
ttgccggga  agtcgctac  tggatcaat  ggttccagt  attaatctc  ctgaacggt  780
atggcatct  aatgaaaat  actgaacca  attgcactg  agtttttga  atacctttg  840
agttactca  gcagttact  cctacactg  tgcaaggat  acagaaact  atgccaagg  900
gctgagtga  ttcaactac  tgttctggg  gcccggaga  agatgactt  gcagatgga  960
agaggtgaa  atgaagaag  aagctgtgt  gaaacagaa  aataagtca  aaggaacaa  1020
aattacaaa  aaccatgca  gaaggaaaa  tatgtatta  tttagaatg  ttgagttac  1080
ttaaaataa  ccaaatatg  taaagttta  gtgtgcagc  atagtttgg  tatttttgg  1140
ttatatgcc  tcaagtaaa  gaaaagccg  aagggttaa  catatttga  aaccatatt  1200
tattgtatt  tgatgagat  ttaaattct  aaagtttta  tataaattc  actaagtta  1260
tttatgaca  gaaaagtta  ttatgctat  aattttttg  aacacaata  ctacaataa  1320
ctggtatga  taattgcat  att  1343



<210> 6690
<211> 165
<212> PRT
<213> Homo sapiens
<308> P24522
<400> 6690

Met Thr Leu Glu Glu Phe Ser Ala Gly Glu Gln Lys Thr Glu Arg Met 
  1               5                  10                  15
Asp Lys Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Leu Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Gln Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Thr Asp Ala Gly Pro Ala Ala 
             100                105                110
Ser Glu Gly Ala Glu Gln Pro Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 6691
<211> 545
<212> DNA
<213> Rattus norvegicus
<308> AI070295
<400> 6691

ttttttttt  tttttttgt  attccatac  agtttattt  agataatgt  cttcaaaaa  60
gttttatca  aaataacct  tcacatcat  aaataactt  gtacgattt  taataaaac  120
tctgagaat  taacatctc  tcaaaatac  ttaaactgt  gcttgaaaa  atgattaac  180
cttttcact  ttcttttat  tgagggcat  aagaccaaa  aaaataccc  aaatattgc  240
acacattta  agtttcaac  aagcaatat  tggtttact  tactgtaac  cggccatcc  300
aaattaata  ttttctttc  tgcacagtt  tttgtagtt  ttttgtccc  tttgacttg  360
atttctgtt  ccacacagc  tcctccttc  gtctcacct  tctctcctt  tgcaaagtc  420
tctcctagc  ctcctgtag  tgaactcag  cccttgaca  cagtttctg  aatccttgc  480
tcagcgtgg  gagtgactg  ttgagtaac  acaaaggta  ttcaaaact  cagtgcaat  540
tggtt  545



<210> 6692
<211> 165
<212> PRT
<213> Rattus norvegicus
<308> P48317
<400> 6692

Met Thr Leu Glu Glu Phe Ser Ala Ala Glu Gln Lys Ile Glu Arg Met 
  1               5                  10                  15
Asp Thr Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Arg Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Arg Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Asn Asp Lys Ser Pro Ala Glu 
             100                105                110
Ser Gly Gly Leu Ala Gln Thr Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 6693
<211> 1343
<212> DNA
<213> Homo sapiens
<308> M60974
<400> 6693

ggcagtggc  gggaggcag  ggcccaatt  gtgtcgtgc  gcccgtggc  aggcgaggt  60
cggggagcg  gcgagcaag  aaggcggga  gggtggccg  agctgcggc  gctggcaca  120
gaggaggag  ccgggcggg  gaggggcgg  cggagagcg  cagggcctg  gctgccgga  180
cggcgcctg  gagtgagtg  agaaagcag  cgcccgcgc  ctagccgtg  caggagcag  240
ccgcacgcc  cgctctctc  ctgggcgac  tgcagtttg  aatatgact  tggaggaat  300
ctcggctgg  gagcagaag  ccgaaagga  ggataaggt  ggggatgcc  tggaggaag  360
gctcagcaa  gccctgagt  agcgcacga  cactgtcgg  gtgtacgaa  cggccaagc  420
gctcaacgt  gaccccgat  acgtggtgt  gtgcctgct  gcggcggac  aggacgacg  480
cagagatgt  gctctgcag  tccacttca  cctgatcca  gcgttttgc  gcgagaacg  540
catcaacat  ctgcgcgtc  gcaacccgg  ccggctggc  gagctcctg  tcttggaga  600
cgacgctgg  cccgcggcg  gcgagggcg  cgagcagcc  ccggacctg  actgcgtgc  660
ggtgacgaa  ccacattca  ctcaatgga  ggatcctgc  ttaagtcaa  ttatttgtt  720
ttgccggga  agtcgctac  tggatcaat  ggttccagt  attaatctc  ctgaacggt  780
atggcatct  aatgaaaat  actgaacca  attgcactg  agtttttga  atacctttg  840
agttactca  gcagttact  cctacactg  tgcaaggat  acagaaact  atgccaagg  900
gctgagtga  ttcaactac  tgttctggg  gcccggaga  agatgactt  gcagatgga  960
agaggtgaa  atgaagaag  aagctgtgt  gaaacagaa  aataagtca  aaggaacaa  1020
aattacaaa  aaccatgca  gaaggaaaa  tatgtatta  tttagaatg  ttgagttac  1080
ttaaaataa  ccaaatatg  taaagttta  gtgtgcagc  atagtttgg  tatttttgg  1140
ttatatgcc  tcaagtaaa  gaaaagccg  aagggttaa  catatttga  aaccatatt  1200
tattgtatt  tgatgagat  ttaaattct  aaagtttta  tataaattc  actaagtta  1260
tttatgaca  gaaaagtta  ttatgctat  aattttttg  aacacaata  ctacaataa  1320
ctggtatga  taattgcat  att  1343



<210> 6694
<211> 165
<212> PRT
<213> Homo sapiens
<308> P24522
<400> 6694

Met Thr Leu Glu Glu Phe Ser Ala Gly Glu Gln Lys Thr Glu Arg Met 
  1               5                  10                  15
Asp Lys Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Leu Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Gln Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Thr Asp Ala Gly Pro Ala Ala 
             100                105                110
Ser Glu Gly Ala Glu Gln Pro Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 6695
<211> 545
<212> DNA
<213> Rattus norvegicus
<308> AI070295
<400> 6695

ttttttttt  tttttttgt  attccatac  agtttattt  agataatgt  cttcaaaaa  60
gttttatca  aaataacct  tcacatcat  aaataactt  gtacgattt  taataaaac  120
tctgagaat  taacatctc  tcaaaatac  ttaaactgt  gcttgaaaa  atgattaac  180
cttttcact  ttcttttat  tgagggcat  aagaccaaa  aaaataccc  aaatattgc  240
acacattta  agtttcaac  aagcaatat  tggtttact  tactgtaac  cggccatcc  300
aaattaata  ttttctttc  tgcacagtt  tttgtagtt  ttttgtccc  tttgacttg  360
atttctgtt  ccacacagc  tcctccttc  gtctcacct  tctctcctt  tgcaaagtc  420
tctcctagc  ctcctgtag  tgaactcag  cccttgaca  cagtttctg  aatccttgc  480
tcagcgtgg  gagtgactg  ttgagtaac  acaaaggta  ttcaaaact  cagtgcaat  540
tggtt  545



<210> 6696
<211> 165
<212> PRT
<213> Rattus norvegicus
<308> P48317
<400> 6696

Met Thr Leu Glu Glu Phe Ser Ala Ala Glu Gln Lys Ile Glu Arg Met 
  1               5                  10                  15
Asp Thr Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Arg Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Arg Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Asn Asp Lys Ser Pro Ala Glu 
             100                105                110
Ser Gly Gly Leu Ala Gln Thr Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 6697
<211> 1343
<212> DNA
<213> Homo sapiens
<308> M60974
<400> 6697

ggcagtggc  gggaggcag  ggcccaatt  gtgtcgtgc  gcccgtggc  aggcgaggt  60
cggggagcg  gcgagcaag  aaggcggga  gggtggccg  agctgcggc  gctggcaca  120
gaggaggag  ccgggcggg  gaggggcgg  cggagagcg  cagggcctg  gctgccgga  180
cggcgcctg  gagtgagtg  agaaagcag  cgcccgcgc  ctagccgtg  caggagcag  240
ccgcacgcc  cgctctctc  ctgggcgac  tgcagtttg  aatatgact  tggaggaat  300
ctcggctgg  gagcagaag  ccgaaagga  ggataaggt  ggggatgcc  tggaggaag  360
gctcagcaa  gccctgagt  agcgcacga  cactgtcgg  gtgtacgaa  cggccaagc  420
gctcaacgt  gaccccgat  acgtggtgt  gtgcctgct  gcggcggac  aggacgacg  480
cagagatgt  gctctgcag  tccacttca  cctgatcca  gcgttttgc  gcgagaacg  540
catcaacat  ctgcgcgtc  gcaacccgg  ccggctggc  gagctcctg  tcttggaga  600
cgacgctgg  cccgcggcg  gcgagggcg  cgagcagcc  ccggacctg  actgcgtgc  660
ggtgacgaa  ccacattca  ctcaatgga  ggatcctgc  ttaagtcaa  ttatttgtt  720
ttgccggga  agtcgctac  tggatcaat  ggttccagt  attaatctc  ctgaacggt  780
atggcatct  aatgaaaat  actgaacca  attgcactg  agtttttga  atacctttg  840
agttactca  gcagttact  cctacactg  tgcaaggat  acagaaact  atgccaagg  900
gctgagtga  ttcaactac  tgttctggg  gcccggaga  agatgactt  gcagatgga  960
agaggtgaa  atgaagaag  aagctgtgt  gaaacagaa  aataagtca  aaggaacaa  1020
aattacaaa  aaccatgca  gaaggaaaa  tatgtatta  tttagaatg  ttgagttac  1080
ttaaaataa  ccaaatatg  taaagttta  gtgtgcagc  atagtttgg  tatttttgg  1140
ttatatgcc  tcaagtaaa  gaaaagccg  aagggttaa  catatttga  aaccatatt  1200
tattgtatt  tgatgagat  ttaaattct  aaagtttta  tataaattc  actaagtta  1260
tttatgaca  gaaaagtta  ttatgctat  aattttttg  aacacaata  ctacaataa  1320
ctggtatga  taattgcat  att  1343



<210> 6698
<211> 165
<212> PRT
<213> Homo sapiens
<308> P24522
<400> 6698

Met Thr Leu Glu Glu Phe Ser Ala Gly Glu Gln Lys Thr Glu Arg Met 
  1               5                  10                  15
Asp Lys Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Leu Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Gln Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Thr Asp Ala Gly Pro Ala Ala 
             100                105                110
Ser Glu Gly Ala Glu Gln Pro Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 6699
<211> 545
<212> DNA
<213> Rattus norvegicus
<308> AI070295
<400> 6699

ttttttttt  tttttttgt  attccatac  agtttattt  agataatgt  cttcaaaaa  60
gttttatca  aaataacct  tcacatcat  aaataactt  gtacgattt  taataaaac  120
tctgagaat  taacatctc  tcaaaatac  ttaaactgt  gcttgaaaa  atgattaac  180
cttttcact  ttcttttat  tgagggcat  aagaccaaa  aaaataccc  aaatattgc  240
acacattta  agtttcaac  aagcaatat  tggtttact  tactgtaac  cggccatcc  300
aaattaata  ttttctttc  tgcacagtt  tttgtagtt  ttttgtccc  tttgacttg  360
atttctgtt  ccacacagc  tcctccttc  gtctcacct  tctctcctt  tgcaaagtc  420
tctcctagc  ctcctgtag  tgaactcag  cccttgaca  cagtttctg  aatccttgc  480
tcagcgtgg  gagtgactg  ttgagtaac  acaaaggta  ttcaaaact  cagtgcaat  540
tggtt  545



<210> 6700
<211> 165
<212> PRT
<213> Rattus norvegicus
<308> P48317
<400> 6700

Met Thr Leu Glu Glu Phe Ser Ala Ala Glu Gln Lys Ile Glu Arg Met 
  1               5                  10                  15
Asp Thr Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Arg Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Arg Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Asn Asp Lys Ser Pro Ala Glu 
             100                105                110
Ser Gly Gly Leu Ala Gln Thr Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 6701
<211> 1343
<212> DNA
<213> Homo sapiens
<308> M60974
<400> 6701

ggcagtggc  gggaggcag  ggcccaatt  gtgtcgtgc  gcccgtggc  aggcgaggt  60
cggggagcg  gcgagcaag  aaggcggga  gggtggccg  agctgcggc  gctggcaca  120
gaggaggag  ccgggcggg  gaggggcgg  cggagagcg  cagggcctg  gctgccgga  180
cggcgcctg  gagtgagtg  agaaagcag  cgcccgcgc  ctagccgtg  caggagcag  240
ccgcacgcc  cgctctctc  ctgggcgac  tgcagtttg  aatatgact  tggaggaat  300
ctcggctgg  gagcagaag  ccgaaagga  ggataaggt  ggggatgcc  tggaggaag  360
gctcagcaa  gccctgagt  agcgcacga  cactgtcgg  gtgtacgaa  cggccaagc  420
gctcaacgt  gaccccgat  acgtggtgt  gtgcctgct  gcggcggac  aggacgacg  480
cagagatgt  gctctgcag  tccacttca  cctgatcca  gcgttttgc  gcgagaacg  540
catcaacat  ctgcgcgtc  gcaacccgg  ccggctggc  gagctcctg  tcttggaga  600
cgacgctgg  cccgcggcg  gcgagggcg  cgagcagcc  ccggacctg  actgcgtgc  660
ggtgacgaa  ccacattca  ctcaatgga  ggatcctgc  ttaagtcaa  ttatttgtt  720
ttgccggga  agtcgctac  tggatcaat  ggttccagt  attaatctc  ctgaacggt  780
atggcatct  aatgaaaat  actgaacca  attgcactg  agtttttga  atacctttg  840
agttactca  gcagttact  cctacactg  tgcaaggat  acagaaact  atgccaagg  900
gctgagtga  ttcaactac  tgttctggg  gcccggaga  agatgactt  gcagatgga  960
agaggtgaa  atgaagaag  aagctgtgt  gaaacagaa  aataagtca  aaggaacaa  1020
aattacaaa  aaccatgca  gaaggaaaa  tatgtatta  tttagaatg  ttgagttac  1080
ttaaaataa  ccaaatatg  taaagttta  gtgtgcagc  atagtttgg  tatttttgg  1140
ttatatgcc  tcaagtaaa  gaaaagccg  aagggttaa  catatttga  aaccatatt  1200
tattgtatt  tgatgagat  ttaaattct  aaagtttta  tataaattc  actaagtta  1260
tttatgaca  gaaaagtta  ttatgctat  aattttttg  aacacaata  ctacaataa  1320
ctggtatga  taattgcat  att  1343



<210> 6702
<211> 165
<212> PRT
<213> Homo sapiens
<308> P24522
<400> 6702

Met Thr Leu Glu Glu Phe Ser Ala Gly Glu Gln Lys Thr Glu Arg Met 
  1               5                  10                  15
Asp Lys Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Leu Ser 
             20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn 
         35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp 
     50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Gln Ala 
 65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly 
                 85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Thr Asp Ala Gly Pro Ala Ala 
             100                105                110
Ser Glu Gly Ala Glu Gln Pro Pro Asp Leu His Cys Val Leu Val Thr 
         115                120                125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile 
     130                135                140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile 
 145                150                155                160
Asn Leu Pro Glu Arg 
                 165



<210> 6703
<211> 561
<212> DNA
<213> Rattus norvegicus
<308> AI070521
<400> 6703

ttttttttt  tttttttaa  tttaaaatg  tttcttaaa  ttatttatt  tttctttaa  60
cataacacg  ggaaggtgt  aaaactggt  taatagctc  atagaataa  tattccaga  120
tttgggagg  atgaagagg  agatattca  aacccttca  cagaatccc  ccaacttga  180
catagtgga  taatgatgt  ctttgtgga  gtggttagt  aatgacacc  gcttgacgg  240
tctttcttt  tgcaccaaa  cccattgag  tatctggtc  ccttggctg  cgaagaacc  300
ttagacgtg  agcactggc  tcatccagg  tgatgttct  taagcgatt  accaaccga  360
caggtcgag  agctgcaac  gctttgggg  cttcacaga  tcgccaaac  ttacaggcg  420
tacatttcc  agtgcgctg  ttaaggatc  ctgagaatt  cacctcatc  cctgcctgt  480
gctcaatgc  atcctgaac  tccttcaca  ggaaaaaga  cttcttgct  tctcctact  540
catagttaa  aaagccaaa  t  561



<210> 6704
<211> 798
<212> PRT
<213> Rattus norvegicus
<308> P18395
<400> 6704

Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
  1               5                  10                  15
Pro Asn Gly Thr Ser Ala Ala Leu Arg Glu Thr Gly Val Ile Glu Lys 
             20                  25                  30
Leu Leu Thr Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg 
         35                  40                  45
Leu Phe Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys 
     50                  55                  60
Val Gly Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Thr Gly 
 65                  70                  75                  80
Lys Pro Ile Ala Ile Lys Leu Val Lys Ile Lys Pro Glu Ile His Pro 
                 85                  90                  95
Glu Glu Arg Met Asn Gly Gln Val Val Cys Ala Val Pro His Asn Leu 
             100                105                110
Glu Ser Lys Ser Pro Ala Ala Pro Gly Gln Ser Pro Thr Gly Ser Val 
         115                120                125
Cys Tyr Glu Arg Asn Gly Glu Val Phe Tyr Leu Thr Tyr Thr Ser Glu 
     130                135                140
Asp Val Glu Gly Asn Val Gln Leu Glu Thr Gly Asp Lys Ile Asn Phe 
 145                150                155                160
Val Ile Asp Asn Asn Lys His Thr Gly Ala Val Ser Ala Arg Asn Ile 
                 165                170                175
Met Leu Leu Lys Lys Lys Gln Ala Arg Tyr Gln Gly Val Val Cys Ala 
             180                185                190
Met Lys Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu 
         195                200                205
Ile Phe Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Thr Leu Gln 
     210                215                220
Pro Gly Asp Asp Val Glu Phe Thr Ile Lys Asp Arg Asn Gly Lys Glu 
 225                230                235                240
Val Ala Thr Asp Val Arg Leu Leu Pro Gln Gly Thr Val Ile Phe Glu 
                 245                250                255
Asp Ile Ser Ile Glu His Phe Glu Gly Thr Val Thr Lys Val Ile Pro 
             260                265                270
Lys Val Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile Lys 
         275                280                285
Val Asp Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp Thr 
     290                295                300
Lys Ser Lys Val Thr Leu Leu Glu Gly Asp His Val Arg Phe Asn Ile 
 305                310                315                320
Ser Thr Asp Arg Arg Asp Lys Leu Glu Arg Ala Thr Asn Ile Glu Val 
                 325                330                335
Leu Ser Asn Thr Phe Gln Phe Thr Asn Glu Ala Arg Glu Met Gly Val 
             340                345                350
Ile Ala Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp Arg 
         355                360                365
Asp Ala Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn Gln 
     370                375                380
Leu His Ile Ala Asp Glu Val Glu Phe Thr Val Val Pro Asp Met Leu 
 385                390                395                400
Ser Ala Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys Gly 
                 405                410                415
Thr Val Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Thr Val 
             420                425                430
Glu Lys Glu Ala Thr Phe Ser Asn Pro Lys Thr Thr Ser Pro Asn Lys 
         435                440                445
Gly Lys Asp Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp Cys 
     450                455                460
Gly Val Lys Leu Thr Ile Ala Phe Gln Ala Lys Asp Val Glu Gly Ser 
 465                470                475                480
Thr Ser Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp Lys 
                 485                490                495
Gln Arg Pro Gly Gln Gln Ile Ala Thr Cys Val Arg Leu Leu Gly Arg 
             500                505                510
Asn Ser Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Thr Leu Lys Asp 
         515                520                525
Asn Phe Gly Phe Ile Glu Thr Ala Asn His Asp Lys Glu Ile Phe Phe 
     530                535                540
His Tyr Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly Asp 
 545                550                555                560
Met Val Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser Ala 
                 565                570                575
Glu Lys Val Asn Lys Thr His Ser Val Asn Gly Ile Thr Glu Glu Ala 
             580                585                590
Asn Pro Thr Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Gly Val 
         595                600                605
Asp Pro Thr Gln Ile Glu Tyr Gln Gly Met Ile Glu Ile Val Glu Glu 
     610                615                620
Gly Asp Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met Ala 
 625                630                635                640
Asn Lys Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln Leu 
                 645                650                655
Cys Val Leu Gly Gln Asn Ala Gln Thr Met Ala Tyr Asn Ile Thr Pro 
             660                665                670
Leu Arg Arg Ala Thr Val Glu Cys Val Lys Asp Gln Phe Gly Phe Ile 
         675                680                685
Asn Tyr Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys Glu 
     690                695                700
Val Gln Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe Ser 
 705                710                715                720
Val Ile Leu Asn Gln Arg Thr Gly Lys Cys Ser Ala Cys Asn Val Trp 
                 725                730                735
Arg Val Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp Arg 
             740                745                750
Leu Val Asn Arg Leu Lys Asn Ile Thr Leu Asp Asp Ala Ser Ala Pro 
         755                760                765
Arg Leu Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met Gly 
     770                775                780
Phe Gly Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
 785                790                795



<210> 6705
<211> 2537
<212> DNA
<213> Homo sapiens
<308> AY049788
<400> 6705

gagtatcac  gcgagatga  ctttgatcc  aaccttctc  acaacaatg  acataatgg  60
taccctaat  gtacttcag  agcactgcg  gaaactggg  ttattgaaa  actgttaac  120
tcttacgga  ttattcagt  ttcagaacg  caagctaga  ttttcttcc  ctgttcaca  180
tataatggc  acctgcaag  cttaaaagt  ggagatgat  ttgaatttg  agtatcatc  240
gaccgacgg  ctgggaaac  cattgctgt  aaactggtg  agataaaac  agaaatcct  300
cctgaagaa  gaatgaatg  acaagaagt  ttttatctg  cttacaccc  tgaagatgt  360
gaagggaac  ttcagctgg  aactggaga  aaaataaac  ttgtaattg  taacaataa  420
catactggt  ctgtaagtg  tcgcaacat  atgctgttg  aaaagaaac  agcccgctg  480
cagggagta  tttgtgcca  gaaggaggc  tttggcttt  ttgaaagag  tgatgttgt  540
aaagagata  tctttcact  tagcgaatt  aagggtgac  tagaaacct  acagcctgg  600
gatgatgtg  aattcacaa  caaggacag  aatggtaaa  aagttgcaa  agatgtcag  660
ctattgcct  aaggaacag  catttttga  gatatcagc  ttgaacatt  tgaaggaac  720
gtaaccaaa  ttatcccaa  agtacccag  aaaaaccag  atgacccat  gccaggacg  780
atcaaagtt  actttgtga  ccctaaaga  cttcccttt  gagacaaag  tacgaaatc  840
aaggtgacc  tgctggaag  tgaccatgt  aggtttaat  tttcaacag  ccgacgtga  900
aaattagag  gagcaacca  tatagaagt  ctgtcaaat  catttcagt  cactaatga  960
gcccgagaa  tgggtgtga  tgctgccat  agagatggt  ttggtttca  caagtgtgt  1020
gatcgtgat  ttcgtatgt  cttccactt  agtgaaatt  tggatggga  ccagctcca  1080
attgcagat  aagtagagt  tactgtggt  cctgatatg  tctctgctc  aagaaatca  1140
gctattagg  ttaaaaaac  tcccaaggg  acggtttca  ttcattccc  ttcagatca  1200
cgttttctg  gcacggtag  aaaagaagc  actttttcc  atcctaaaa  cactagccc  1260
aataaaggc  aagagaagg  ggctgagga  ggcattatt  cttatgatg  ctgtggggt  1320
aaactgact  ttgcttttc  agccaagga  gtggaagga  ctacttctc  tcaaatagg  1380
gataaggtt  aatttagta  tagtgacaa  cagaggcct  gacagcagg  tgcaacttg  1440
gtgcgactt  taggtcgta  ttctaactc  aagaggctc  tgggttatg  ggcaactct  1500
aaggataat  ttggattta  tgaaacagc  aatcatgat  aggaaatct  tttccatta  1560
agtgagttc  ctggtgatg  tgatagcct  gaactgggg  acatggtcg  gtatagctt  1620
tccaaaggc  aaggcaaca  agtcagtgc  gaaaaagtg  acaaaacac  ctcagtgaa  1680
ggcattact  aggaagctg  tcccaccat  tactctggc  aagtaattc  ccccctgag  1740
agtgttgat  caacacaga  tgagtacca  ggaatgatt  agattgtgg  ggagggcga  1800
atgaaaggt  aggtctatc  atttggcat  gttgggatg  ccaacaaag  ggattgcct  1860
cagaaaggg  agagcgtca  gttccaatt  tgtgtcctg  gccaaaatg  acaaactat  1920
gcttacaac  tcacacccc  gcgcagggc  acagtggaa  gtgtgaaag  tcagtttgg  1980
ttcattaac  atgaagtag  agatagcaa  aagctcttt  tccatgtga  agaagttca  2040
gatggcatt  agctacagg  aggagatga  gtggagttc  cagtgattc  taatcagcg  2100
actggcaag  gcagcgcct  taatgtttg  cgagtctgg  gagggcccc  aggctgttg  2160
agctcctcg  cctgatcgg  tggtcaatc  cttgaagaa  atcactctg  atgatgcca  2220
tgctcctcg  ctaatggtt  ttcgtcagc  aaggggacc  gataactca  tggggtttg  2280
tgcagaaag  aagatccgt  aagctggtg  cattgacta  ccacatcca  aaagcacac  2340
attaatcca  tatgatcaa  ttgggggga  tctggtgaa  ggttctgaa  atctccctc  2400
tcatccctc  cgaaatctg  aatacttat  ctattgagc  attacacca  ttttaacac  2460
ttcctcgtg  tatgtttaa  aaaataaat  aatttaaga  aaccatttt  aataatgca  2520
agttgcagc  tggaaaa  2537



<210> 6706
<211> 798
<212> PRT
<213> Homo sapiens
<308> O75534
<400> 6706

Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
  1               5                  10                  15
Pro Asn Gly Thr Ser Ala Ala Leu Arg Glu Thr Gly Val Ile Glu Lys 
             20                  25                  30
Leu Leu Thr Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg 
         35                  40                  45
Leu Phe Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys 
     50                  55                  60
Val Gly Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Thr Gly 
 65                  70                  75                  80
Lys Pro Ile Ala Val Lys Leu Val Lys Ile Lys Gln Glu Ile Leu Pro 
                 85                  90                  95
Glu Glu Arg Met Asn Gly Gln Val Val Cys Ala Val Pro His Asn Leu 
             100                105                110
Glu Ser Lys Ser Pro Ala Ala Pro Gly Gln Ser Pro Thr Gly Ser Val 
         115                120                125
Cys Tyr Glu Arg Asn Gly Glu Val Phe Tyr Leu Thr Tyr Thr Pro Glu 
     130                135                140
Asp Val Glu Gly Asn Val Gln Leu Glu Thr Gly Asp Lys Ile Asn Phe 
 145                150                155                160
Val Ile Asp Asn Asn Lys His Thr Gly Ala Val Ser Ala Arg Asn Ile 
                 165                170                175
Met Leu Leu Lys Lys Lys Gln Ala Arg Cys Gln Gly Val Val Cys Ala 
             180                185                190
Met Lys Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu 
         195                200                205
Ile Phe Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Thr Leu Gln 
     210                215                220
Pro Gly Asp Asp Val Glu Phe Thr Ile Lys Asp Arg Asn Gly Lys Glu 
 225                230                235                240
Val Ala Thr Asp Val Arg Leu Leu Pro Gln Gly Thr Val Ile Phe Glu 
                 245                250                255
Asp Ile Ser Ile Glu His Phe Glu Gly Thr Val Thr Lys Val Ile Pro 
             260                265                270
Lys Val Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile Lys 
         275                280                285
Val Asp Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp Thr 
     290                295                300
Lys Ser Lys Val Thr Leu Leu Glu Gly Asp His Val Arg Phe Asn Ile 
 305                310                315                320
Ser Thr Asp Arg Arg Asp Lys Leu Glu Arg Ala Thr Asn Ile Glu Val 
                 325                330                335
Leu Ser Asn Thr Phe Gln Phe Thr Asn Glu Ala Arg Glu Met Gly Val 
             340                345                350
Ile Ala Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp Arg 
         355                360                365
Asp Val Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn Gln 
     370                375                380
Leu His Ile Ala Asp Glu Val Glu Phe Thr Val Val Pro Asp Met Leu 
 385                390                395                400
Ser Ala Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys Gly 
                 405                410                415
Thr Val Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Thr Val 
             420                425                430
Glu Lys Glu Ala Thr Phe Ser Asn Pro Lys Thr Thr Ser Pro Asn Lys 
         435                440                445
Gly Lys Glu Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp Cys 
     450                455                460
Gly Val Lys Leu Thr Ile Ala Phe Gln Ala Lys Asp Val Glu Gly Ser 
 465                470                475                480
Thr Ser Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp Lys 
                 485                490                495
Gln Arg Pro Gly Gln Gln Val Ala Thr Cys Val Arg Leu Leu Gly Arg 
             500                505                510
Asn Ser Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Thr Leu Lys Asp 
         515                520                525
Asn Phe Gly Phe Ile Glu Thr Ala Asn His Asp Lys Glu Ile Phe Phe 
     530                535                540
His Tyr Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly Asp 
 545                550                555                560
Met Val Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser Ala 
                 565                570                575
Glu Lys Val Asn Lys Thr His Ser Val Asn Gly Ile Thr Glu Glu Ala 
             580                585                590
Asp Pro Thr Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Ser Val 
         595                600                605
Asp Pro Thr Gln Thr Glu Tyr Gln Gly Met Ile Glu Ile Val Glu Glu 
     610                615                620
Gly Asp Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met Ala 
 625                630                635                640
Asn Lys Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln Leu 
                 645                650                655
Cys Val Leu Gly Gln Asn Ala Gln Thr Met Ala Tyr Asn Ile Thr Pro 
             660                665                670
Leu Arg Arg Ala Thr Val Glu Cys Val Lys Asp Gln Phe Gly Phe Ile 
         675                680                685
Asn Tyr Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys Glu 
     690                695                700
Val Gln Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe Ser 
 705                710                715                720
Val Ile Leu Asn Gln Arg Thr Gly Lys Cys Ser Ala Cys Asn Val Trp 
                 725                730                735
Arg Val Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp Arg 
             740                745                750
Leu Val Asn Arg Leu Lys Asn Ile Thr Leu Asp Asp Ala Ser Ala Pro 
         755                760                765
Arg Leu Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met Gly 
     770                775                780
Phe Gly Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
 785                790                795



<210> 6707
<211> 561
<212> DNA
<213> Rattus norvegicus
<308> AI070521
<400> 6707

ttttttttt  tttttttaa  tttaaaatg  tttcttaaa  ttatttatt  tttctttaa  60
cataacacg  ggaaggtgt  aaaactggt  taatagctc  atagaataa  tattccaga  120
tttgggagg  atgaagagg  agatattca  aacccttca  cagaatccc  ccaacttga  180
catagtgga  taatgatgt  ctttgtgga  gtggttagt  aatgacacc  gcttgacgg  240
tctttcttt  tgcaccaaa  cccattgag  tatctggtc  ccttggctg  cgaagaacc  300
ttagacgtg  agcactggc  tcatccagg  tgatgttct  taagcgatt  accaaccga  360
caggtcgag  agctgcaac  gctttgggg  cttcacaga  tcgccaaac  ttacaggcg  420
tacatttcc  agtgcgctg  ttaaggatc  ctgagaatt  cacctcatc  cctgcctgt  480
gctcaatgc  atcctgaac  tccttcaca  ggaaaaaga  cttcttgct  tctcctact  540
catagttaa  aaagccaaa  t  561



<210> 6708
<211> 798
<212> PRT
<213> Rattus norvegicus
<308> P18395
<400> 6708

Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
  1               5                  10                  15
Pro Asn Gly Thr Ser Ala Ala Leu Arg Glu Thr Gly Val Ile Glu Lys 
             20                  25                  30
Leu Leu Thr Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg 
         35                  40                  45
Leu Phe Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys 
     50                  55                  60
Val Gly Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Thr Gly 
 65                  70                  75                  80
Lys Pro Ile Ala Ile Lys Leu Val Lys Ile Lys Pro Glu Ile His Pro 
                 85                  90                  95
Glu Glu Arg Met Asn Gly Gln Val Val Cys Ala Val Pro His Asn Leu 
             100                105                110
Glu Ser Lys Ser Pro Ala Ala Pro Gly Gln Ser Pro Thr Gly Ser Val 
         115                120                125
Cys Tyr Glu Arg Asn Gly Glu Val Phe Tyr Leu Thr Tyr Thr Ser Glu 
     130                135                140
Asp Val Glu Gly Asn Val Gln Leu Glu Thr Gly Asp Lys Ile Asn Phe 
 145                150                155                160
Val Ile Asp Asn Asn Lys His Thr Gly Ala Val Ser Ala Arg Asn Ile 
                 165                170                175
Met Leu Leu Lys Lys Lys Gln Ala Arg Tyr Gln Gly Val Val Cys Ala 
             180                185                190
Met Lys Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu 
         195                200                205
Ile Phe Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Thr Leu Gln 
     210                215                220
Pro Gly Asp Asp Val Glu Phe Thr Ile Lys Asp Arg Asn Gly Lys Glu 
 225                230                235                240
Val Ala Thr Asp Val Arg Leu Leu Pro Gln Gly Thr Val Ile Phe Glu 
                 245                250                255
Asp Ile Ser Ile Glu His Phe Glu Gly Thr Val Thr Lys Val Ile Pro 
             260                265                270
Lys Val Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile Lys 
         275                280                285
Val Asp Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp Thr 
     290                295                300
Lys Ser Lys Val Thr Leu Leu Glu Gly Asp His Val Arg Phe Asn Ile 
 305                310                315                320
Ser Thr Asp Arg Arg Asp Lys Leu Glu Arg Ala Thr Asn Ile Glu Val 
                 325                330                335
Leu Ser Asn Thr Phe Gln Phe Thr Asn Glu Ala Arg Glu Met Gly Val 
             340                345                350
Ile Ala Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp Arg 
         355                360                365
Asp Ala Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn Gln 
     370                375                380
Leu His Ile Ala Asp Glu Val Glu Phe Thr Val Val Pro Asp Met Leu 
 385                390                395                400
Ser Ala Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys Gly 
                 405                410                415
Thr Val Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Thr Val 
             420                425                430
Glu Lys Glu Ala Thr Phe Ser Asn Pro Lys Thr Thr Ser Pro Asn Lys 
         435                440                445
Gly Lys Asp Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp Cys 
     450                455                460
Gly Val Lys Leu Thr Ile Ala Phe Gln Ala Lys Asp Val Glu Gly Ser 
 465                470                475                480
Thr Ser Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp Lys 
                 485                490                495
Gln Arg Pro Gly Gln Gln Ile Ala Thr Cys Val Arg Leu Leu Gly Arg 
             500                505                510
Asn Ser Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Thr Leu Lys Asp 
         515                520                525
Asn Phe Gly Phe Ile Glu Thr Ala Asn His Asp Lys Glu Ile Phe Phe 
     530                535                540
His Tyr Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly Asp 
 545                550                555                560
Met Val Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser Ala 
                 565                570                575
Glu Lys Val Asn Lys Thr His Ser Val Asn Gly Ile Thr Glu Glu Ala 
             580                585                590
Asn Pro Thr Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Gly Val 
         595                600                605
Asp Pro Thr Gln Ile Glu Tyr Gln Gly Met Ile Glu Ile Val Glu Glu 
     610                615                620
Gly Asp Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met Ala 
 625                630                635                640
Asn Lys Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln Leu 
                 645                650                655
Cys Val Leu Gly Gln Asn Ala Gln Thr Met Ala Tyr Asn Ile Thr Pro 
             660                665                670
Leu Arg Arg Ala Thr Val Glu Cys Val Lys Asp Gln Phe Gly Phe Ile 
         675                680                685
Asn Tyr Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys Glu 
     690                695                700
Val Gln Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe Ser 
 705                710                715                720
Val Ile Leu Asn Gln Arg Thr Gly Lys Cys Ser Ala Cys Asn Val Trp 
                 725                730                735
Arg Val Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp Arg 
             740                745                750
Leu Val Asn Arg Leu Lys Asn Ile Thr Leu Asp Asp Ala Ser Ala Pro 
         755                760                765
Arg Leu Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met Gly 
     770                775                780
Phe Gly Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
 785                790                795



<210> 6709
<211> 2537
<212> DNA
<213> Homo sapiens
<308> AY049788
<400> 6709

gagtatcac  gcgagatga  ctttgatcc  aaccttctc  acaacaatg  acataatgg  60
taccctaat  gtacttcag  agcactgcg  gaaactggg  ttattgaaa  actgttaac  120
tcttacgga  ttattcagt  ttcagaacg  caagctaga  ttttcttcc  ctgttcaca  180
tataatggc  acctgcaag  cttaaaagt  ggagatgat  ttgaatttg  agtatcatc  240
gaccgacgg  ctgggaaac  cattgctgt  aaactggtg  agataaaac  agaaatcct  300
cctgaagaa  gaatgaatg  acaagaagt  ttttatctg  cttacaccc  tgaagatgt  360
gaagggaac  ttcagctgg  aactggaga  aaaataaac  ttgtaattg  taacaataa  420
catactggt  ctgtaagtg  tcgcaacat  atgctgttg  aaaagaaac  agcccgctg  480
cagggagta  tttgtgcca  gaaggaggc  tttggcttt  ttgaaagag  tgatgttgt  540
aaagagata  tctttcact  tagcgaatt  aagggtgac  tagaaacct  acagcctgg  600
gatgatgtg  aattcacaa  caaggacag  aatggtaaa  aagttgcaa  agatgtcag  660
ctattgcct  aaggaacag  catttttga  gatatcagc  ttgaacatt  tgaaggaac  720
gtaaccaaa  ttatcccaa  agtacccag  aaaaaccag  atgacccat  gccaggacg  780
atcaaagtt  actttgtga  ccctaaaga  cttcccttt  gagacaaag  tacgaaatc  840
aaggtgacc  tgctggaag  tgaccatgt  aggtttaat  tttcaacag  ccgacgtga  900
aaattagag  gagcaacca  tatagaagt  ctgtcaaat  catttcagt  cactaatga  960
gcccgagaa  tgggtgtga  tgctgccat  agagatggt  ttggtttca  caagtgtgt  1020
gatcgtgat  ttcgtatgt  cttccactt  agtgaaatt  tggatggga  ccagctcca  1080
attgcagat  aagtagagt  tactgtggt  cctgatatg  tctctgctc  aagaaatca  1140
gctattagg  ttaaaaaac  tcccaaggg  acggtttca  ttcattccc  ttcagatca  1200
cgttttctg  gcacggtag  aaaagaagc  actttttcc  atcctaaaa  cactagccc  1260
aataaaggc  aagagaagg  ggctgagga  ggcattatt  cttatgatg  ctgtggggt  1320
aaactgact  ttgcttttc  agccaagga  gtggaagga  ctacttctc  tcaaatagg  1380
gataaggtt  aatttagta  tagtgacaa  cagaggcct  gacagcagg  tgcaacttg  1440
gtgcgactt  taggtcgta  ttctaactc  aagaggctc  tgggttatg  ggcaactct  1500
aaggataat  ttggattta  tgaaacagc  aatcatgat  aggaaatct  tttccatta  1560
agtgagttc  ctggtgatg  tgatagcct  gaactgggg  acatggtcg  gtatagctt  1620
tccaaaggc  aaggcaaca  agtcagtgc  gaaaaagtg  acaaaacac  ctcagtgaa  1680
ggcattact  aggaagctg  tcccaccat  tactctggc  aagtaattc  ccccctgag  1740
agtgttgat  caacacaga  tgagtacca  ggaatgatt  agattgtgg  ggagggcga  1800
atgaaaggt  aggtctatc  atttggcat  gttgggatg  ccaacaaag  ggattgcct  1860
cagaaaggg  agagcgtca  gttccaatt  tgtgtcctg  gccaaaatg  acaaactat  1920
gcttacaac  tcacacccc  gcgcagggc  acagtggaa  gtgtgaaag  tcagtttgg  1980
ttcattaac  atgaagtag  agatagcaa  aagctcttt  tccatgtga  agaagttca  2040
gatggcatt  agctacagg  aggagatga  gtggagttc  cagtgattc  taatcagcg  2100
actggcaag  gcagcgcct  taatgtttg  cgagtctgg  gagggcccc  aggctgttg  2160
agctcctcg  cctgatcgg  tggtcaatc  cttgaagaa  atcactctg  atgatgcca  2220
tgctcctcg  ctaatggtt  ttcgtcagc  aaggggacc  gataactca  tggggtttg  2280
tgcagaaag  aagatccgt  aagctggtg  cattgacta  ccacatcca  aaagcacac  2340
attaatcca  tatgatcaa  ttgggggga  tctggtgaa  ggttctgaa  atctccctc  2400
tcatccctc  cgaaatctg  aatacttat  ctattgagc  attacacca  ttttaacac  2460
ttcctcgtg  tatgtttaa  aaaataaat  aatttaaga  aaccatttt  aataatgca  2520
agttgcagc  tggaaaa  2537



<210> 6710
<211> 798
<212> PRT
<213> Homo sapiens
<308> O75534
<400> 6710

Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
  1               5                  10                  15
Pro Asn Gly Thr Ser Ala Ala Leu Arg Glu Thr Gly Val Ile Glu Lys 
             20                  25                  30
Leu Leu Thr Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg 
         35                  40                  45
Leu Phe Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys 
     50                  55                  60
Val Gly Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Thr Gly 
 65                  70                  75                  80
Lys Pro Ile Ala Val Lys Leu Val Lys Ile Lys Gln Glu Ile Leu Pro 
                 85                  90                  95
Glu Glu Arg Met Asn Gly Gln Val Val Cys Ala Val Pro His Asn Leu 
             100                105                110
Glu Ser Lys Ser Pro Ala Ala Pro Gly Gln Ser Pro Thr Gly Ser Val 
         115                120                125
Cys Tyr Glu Arg Asn Gly Glu Val Phe Tyr Leu Thr Tyr Thr Pro Glu 
     130                135                140
Asp Val Glu Gly Asn Val Gln Leu Glu Thr Gly Asp Lys Ile Asn Phe 
 145                150                155                160
Val Ile Asp Asn Asn Lys His Thr Gly Ala Val Ser Ala Arg Asn Ile 
                 165                170                175
Met Leu Leu Lys Lys Lys Gln Ala Arg Cys Gln Gly Val Val Cys Ala 
             180                185                190
Met Lys Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu 
         195                200                205
Ile Phe Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Thr Leu Gln 
     210                215                220
Pro Gly Asp Asp Val Glu Phe Thr Ile Lys Asp Arg Asn Gly Lys Glu 
 225                230                235                240
Val Ala Thr Asp Val Arg Leu Leu Pro Gln Gly Thr Val Ile Phe Glu 
                 245                250                255
Asp Ile Ser Ile Glu His Phe Glu Gly Thr Val Thr Lys Val Ile Pro 
             260                265                270
Lys Val Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile Lys 
         275                280                285
Val Asp Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp Thr 
     290                295                300
Lys Ser Lys Val Thr Leu Leu Glu Gly Asp His Val Arg Phe Asn Ile 
 305                310                315                320
Ser Thr Asp Arg Arg Asp Lys Leu Glu Arg Ala Thr Asn Ile Glu Val 
                 325                330                335
Leu Ser Asn Thr Phe Gln Phe Thr Asn Glu Ala Arg Glu Met Gly Val 
             340                345                350
Ile Ala Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp Arg 
         355                360                365
Asp Val Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn Gln 
     370                375                380
Leu His Ile Ala Asp Glu Val Glu Phe Thr Val Val Pro Asp Met Leu 
 385                390                395                400
Ser Ala Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys Gly 
                 405                410                415
Thr Val Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Thr Val 
             420                425                430
Glu Lys Glu Ala Thr Phe Ser Asn Pro Lys Thr Thr Ser Pro Asn Lys 
         435                440                445
Gly Lys Glu Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp Cys 
     450                455                460
Gly Val Lys Leu Thr Ile Ala Phe Gln Ala Lys Asp Val Glu Gly Ser 
 465                470                475                480
Thr Ser Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp Lys 
                 485                490                495
Gln Arg Pro Gly Gln Gln Val Ala Thr Cys Val Arg Leu Leu Gly Arg 
             500                505                510
Asn Ser Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Thr Leu Lys Asp 
         515                520                525
Asn Phe Gly Phe Ile Glu Thr Ala Asn His Asp Lys Glu Ile Phe Phe 
     530                535                540
His Tyr Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly Asp 
 545                550                555                560
Met Val Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser Ala 
                 565                570                575
Glu Lys Val Asn Lys Thr His Ser Val Asn Gly Ile Thr Glu Glu Ala 
             580                585                590
Asp Pro Thr Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Ser Val 
         595                600                605
Asp Pro Thr Gln Thr Glu Tyr Gln Gly Met Ile Glu Ile Val Glu Glu 
     610                615                620
Gly Asp Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met Ala 
 625                630                635                640
Asn Lys Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln Leu 
                 645                650                655
Cys Val Leu Gly Gln Asn Ala Gln Thr Met Ala Tyr Asn Ile Thr Pro 
             660                665                670
Leu Arg Arg Ala Thr Val Glu Cys Val Lys Asp Gln Phe Gly Phe Ile 
         675                680                685
Asn Tyr Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys Glu 
     690                695                700
Val Gln Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe Ser 
 705                710                715                720
Val Ile Leu Asn Gln Arg Thr Gly Lys Cys Ser Ala Cys Asn Val Trp 
                 725                730                735
Arg Val Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp Arg 
             740                745                750
Leu Val Asn Arg Leu Lys Asn Ile Thr Leu Asp Asp Ala Ser Ala Pro 
         755                760                765
Arg Leu Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met Gly 
     770                775                780
Phe Gly Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
 785                790                795



<210> 6711
<211> 366
<212> DNA
<213> Rattus norvegicus
<308> AI070721
<400> 6711

ttttttttt  tttttttca  actgttttc  cggatgcag  tacgacgtt  ctgccaacg  60
tacagataa  agggcagca  gggcggtga  catcagcac  ggcagtgag  tcagactgc  120
gctgggagg  gcagctttg  ttttgtggt  atgtggctg  aggcaccag  gagaccatc  180
tttccgaaa  cactatcag  aagacagag  tgtgtgcta  ccgacacat  ggatttcag  240
ttctgagcc  gcaaattcg  acagggtgg  aaaacgtgt  tggggatct  attctcaga  300
cctgctggc  ccagaaggc  tgttcttga  tggaggggc  ggctgccac  tggtcacat  360
tgagcc  366



<210> 6712
<211> 468
<212> PRT
<213> Rattus norvegicus
<308> Q62997
<400> 6712

Met Phe Leu Ala Thr Leu Tyr Phe Ala Leu Pro Leu Leu Asp Leu Leu 
  1               5                  10                  15
Met Ser Ala Glu Val Ser Gly Gly Asp Arg Leu Asp Cys Val Lys Ala 
             20                  25                  30
Ser Asp Gln Cys Leu Lys Glu Gln Ser Cys Ser Thr Lys Tyr Arg Thr 
         35                  40                  45
Leu Arg Gln Cys Val Ala Gly Lys Glu Thr Asn Phe Ser Leu Thr Ser 
     50                  55                  60
Gly Leu Glu Ala Lys Asp Glu Cys Arg Ser Ala Met Glu Ala Leu Lys 
 65                  70                  75                  80
Gln Lys Ser Leu Tyr Asn Cys Arg Cys Lys Arg Gly Met Lys Lys Glu 
                 85                  90                  95
Lys Asn Cys Leu Arg Ile Tyr Trp Ser Met Tyr Gln Ser Leu Gln Gly 
             100                105                110
Asn Asp Leu Leu Glu Asp Ser Pro Tyr Glu Pro Val Asn Ser Arg Leu 
         115                120                125
Ser Asp Ile Phe Arg Ala Val Pro Phe Ile Ser Asp Val Phe Gln Gln 
     130                135                140
Val Glu His Ile Ser Lys Gly Asn Asn Cys Leu Asp Ala Ala Lys Ala 
 145                150                155                160
Cys Asn Leu Asp Asp Thr Cys Lys Lys Tyr Arg Ser Ala Tyr Ile Thr 
                 165                170                175
Pro Cys Thr Thr Ser Met Ser Asn Glu Val Cys Asn Arg Arg Lys Cys 
             180                185                190
His Lys Ala Leu Arg Gln Phe Phe Asp Lys Val Pro Ala Lys His Ser 
         195                200                205
Tyr Gly Met Leu Phe Cys Ser Cys Arg Asp Ile Ala Cys Thr Glu Arg 
     210                215                220
Arg Arg Gln Thr Ile Val Pro Val Cys Ser Tyr Glu Glu Arg Glu Arg 
 225                230                235                240
Pro Asn Cys Leu Ser Leu Gln Asp Ser Cys Lys Thr Asn Tyr Ile Cys 
                 245                250                255
Arg Ser Arg Leu Ala Asp Phe Phe Thr Asn Cys Gln Pro Glu Ser Arg 
             260                265                270
Ser Val Ser Asn Cys Leu Lys Glu Asn Tyr Ala Asp Cys Leu Leu Ala 
         275                280                285
Tyr Ser Gly Leu Ile Gly Thr Val Met Thr Pro Asn Tyr Val Asp Ser 
     290                295                300
Ser Ser Leu Ser Val Ala Pro Trp Cys Asp Cys Ser Asn Ser Gly Asn 
 305                310                315                320
Asp Leu Glu Asp Cys Leu Lys Phe Leu Asn Phe Phe Lys Asp Asn Thr 
                 325                330                335
Cys Leu Lys Asn Ala Ile Gln Ala Phe Gly Asn Gly Ser Asp Val Thr 
             340                345                350
Met Trp Gln Pro Ala Pro Pro Val Gln Thr Thr Thr Ala Thr Thr Thr 
         355                360                365
Thr Ala Phe Arg Val Lys Asn Lys Pro Leu Gly Pro Ala Gly Ser Glu 
     370                375                380
Asn Glu Ile Pro Thr His Val Leu Pro Pro Cys Ala Asn Leu Gln Ala 
 385                390                395                400
Gln Lys Leu Lys Ser Asn Val Ser Gly Ser Thr His Leu Cys Leu Ser 
                 405                410                415
Asp Ser Asp Phe Gly Lys Asp Gly Leu Ala Gly Ala Ser Ser His Ile 
             420                425                430
Thr Thr Lys Ser Met Ala Ala Pro Pro Ser Cys Ser Leu Ser Ser Leu 
         435                440                445
Pro Val Leu Met Leu Thr Ala Leu Ala Ala Leu Leu Ser Val Ser Leu 
     450                455                460
Ala Glu Thr Ser 
 465



<210> 6713
<211> 1619
<212> DNA
<213> Homo sapiens
<308> AF042080
<400> 6713

cagagcagc  cagctgtcc  gggatcgct  cacgctgag  tccctcggc  agacccagc  60
gcggctcgg  atttttttg  gggggcggg  accagcccc  cgccggcac  atgttcctg  120
cgaccctgt  cttcgcgct  ccgctcttg  acttgctcc  gtcggccga  gtgagcggc  180
gagaccgcc  ggattgcgt  aaagccagt  atcagtgcc  gaaggagca  agctgcagc  240
ccaagtacc  cacgctaag  cagtgcgtg  cgggcaagg  gaccaactt  agcctggca  300
ccggcctgg  ggccaagga  gagtgccgc  gcgccatgg  ggccctgaa  cagaagtcg  360
tctacaact  ccgctgcaa  cggggtatg  agaaggaga  gaactgcct  cgcatttac  420
ggagcatgt  ccagagcct  cagggaaat  atctgctgg  ggattcccc  tatgaacca  480
ttaacagca  attgtcaga  atattccgg  tggtcccat  catatcaga  gtttttcag  540
aagtggagc  cattcccaa  gggaacaac  gcctggatg  agcgaaggc  tgcaacctc  600
acgacattt  caagaagta  aggtcggcg  acatcaccc  gtgcaccac  agcgtgtcc  660
acgatgtct  caaccgccg  aagtgccac  aggccctcc  gcagttctt  gacaaggtc  720
cggccaagc  cagctacgg  atgctcttc  gctcctgcc  ggacatcgc  tgcacagag  780
ggaggcgac  gaccatcgt  cctgtgtgc  cctatgaag  gagggagaa  cccaactgt  840
tgaatttgc  ggactcctg  aagacgaat  acatctgca  atctcgcct  gcggatttt  900
ttaccaact  ccagccaga  tcaaggtct  tcagcagct  tctaaagga  aactacgct  960
actgcctcc  cgcctactc  gggcttatt  gcacagtca  gacccccaa  tacatagac  1020
ccagtagcc  cagtgtggc  ccatggtgt  actgcagca  cagtgggaa  gacctagaa  1080
agtgcttga  atttttgaa  ttcttcaag  acaatacat  tcttaaaaa  gcaattcaa  1140
cctttggca  tggctccga  gtgaccgtg  ggcagccag  cttcccagt  cagaccacc  1200
ctgccacta  caccactgc  ctccgggtt  agaacaagc  cctggggcc  gcagggtct  1260
agaatgaaa  tcccactca  gttttgcca  cgtgtgcaa  tttacaggc  cagaagctg  1320
aatccaatg  gtcgggcaa  acacacctc  gtatttcca  tggtaatta  gaaaaagaa  1380
gtctcggtg  ttccagcca  ataaccaca  aatcaatgg  tgctcctcc  agctgtggt  1440
tgagcccac  gctggtcct  gtggtaacc  ctctgtcca  cctattatc  ttaacagaa  1500
catcatagc  gcattaaaa  aatacaata  ggacatgta  aaagacaaa  accaagtta  1560
ctgtttcct  ttctcttgt  tagctgaaa  tccagttta  gagctcagt  gagaaacag  1619



<210> 6714
<211> 465
<212> PRT
<213> Homo sapiens
<308> P56159
<400> 6714

Met Phe Leu Ala Thr Leu Tyr Phe Ala Leu Pro Leu Leu Asp Leu Leu 
  1               5                  10                  15
Leu Ser Ala Glu Val Ser Gly Gly Asp Arg Leu Asp Cys Val Lys Ala 
             20                  25                  30
Ser Asp Gln Cys Leu Lys Glu Gln Ser Cys Ser Thr Lys Tyr Arg Thr 
         35                  40                  45
Leu Arg Gln Cys Val Ala Gly Lys Glu Thr Asn Phe Ser Leu Ala Ser 
     50                  55                  60
Gly Leu Glu Ala Lys Asp Glu Cys Arg Ser Ala Met Glu Ala Leu Lys 
 65                  70                  75                  80
Gln Lys Ser Leu Tyr Asn Cys Arg Cys Lys Arg Gly Met Lys Lys Glu 
                 85                  90                  95
Lys Asn Cys Leu Arg Ile Tyr Trp Ser Met Tyr Gln Ser Leu Gln Gly 
             100                105                110
Asn Asp Leu Leu Glu Asp Ser Pro Tyr Glu Pro Val Asn Ser Arg Leu 
         115                120                125
Ser Asp Ile Phe Arg Val Val Pro Phe Ile Ser Asp Val Phe Gln Gln 
     130                135                140
Val Glu His Ile Pro Lys Gly Asn Asn Cys Leu Asp Ala Ala Lys Ala 
 145                150                155                160
Cys Asn Leu Asp Asp Ile Cys Lys Lys Tyr Arg Ser Ala Tyr Ile Thr 
                 165                170                175
Pro Cys Thr Thr Ser Val Ser Asn Asp Val Cys Asn Arg Arg Lys Cys 
             180                185                190
His Lys Ala Leu Arg Gln Phe Phe Asp Lys Val Pro Ala Lys His Ser 
         195                200                205
Tyr Gly Met Leu Phe Cys Ser Cys Arg Asp Ile Ala Cys Thr Glu Arg 
     210                215                220
Arg Arg Gln Thr Ile Val Pro Val Cys Ser Tyr Glu Glu Arg Glu Lys 
 225                230                235                240
Pro Asn Cys Leu Asn Leu Gln Asp Ser Cys Lys Thr Asn Tyr Ile Cys 
                 245                250                255
Arg Ser Arg Leu Ala Asp Phe Phe Thr Asn Cys Gln Pro Glu Ser Arg 
             260                265                270
Ser Val Ser Ser Cys Leu Lys Glu Asn Tyr Ala Asp Cys Leu Leu Ala 
         275                280                285
Tyr Ser Gly Leu Ile Gly Thr Val Met Thr Pro Asn Tyr Ile Asp Ser 
     290                295                300
Ser Ser Leu Ser Val Ala Pro Trp Cys Asp Cys Ser Asn Ser Gly Asn 
 305                310                315                320
Asp Leu Glu Glu Cys Leu Lys Phe Leu Asn Phe Phe Lys Asp Asn Thr 
                 325                330                335
Cys Leu Lys Asn Ala Ile Gln Ala Phe Gly Asn Gly Ser Asp Val Thr 
             340                345                350
Val Trp Gln Pro Ala Phe Pro Val Gln Thr Thr Thr Ala Thr Thr Thr 
         355                360                365
Thr Ala Leu Arg Val Lys Asn Lys Pro Leu Gly Pro Ala Gly Ser Glu 
     370                375                380
Asn Glu Ile Pro Thr His Val Leu Pro Pro Cys Ala Asn Leu Gln Ala 
 385                390                395                400
Gln Lys Leu Lys Ser Asn Val Ser Gly Asn Thr His Leu Cys Ile Ser 
                 405                410                415
Asn Gly Asn Tyr Glu Lys Glu Gly Leu Gly Ala Ser Ser His Ile Thr 
             420                425                430
Thr Lys Ser Met Ala Ala Pro Pro Ser Cys Gly Leu Ser Pro Leu Leu 
         435                440                445
Val Leu Val Val Thr Ala Leu Ser Thr Leu Leu Ser Leu Thr Glu Thr 
     450                455                460
Ser 
 465



<210> 6715
<211> 448
<212> DNA
<213> Rattus norvegicus
<308> AI070967
<400> 6715

cggccgcaa  ggttttttt  agagctgcg  aacaggacg  cctctgatg  gaaagagct  60
gtcctggat  actgtcggt  aattgaagg  aaaatcgaa  gcctcacgg  tgagtttga  120
gaactggaa  tcctaagta  aatcaacgt  ggcctcacc  ccatttcca  cttaccaaa  180
ttaaacaaa  tcaagaagc  tgaattaag  gaaaacaga  tctcagggg  cctggaagt  240
ttggcagag  aatgtccga  ccttaagca  ctaaattta  gtggcaaca  aataaaaga  300
ctcagcaca  tagagccgc  gaagaagtt  gagaatctc  agagcctag  cctgtttaa  360
tgtgaggtg  ccaacctga  tgcctaccg  gaaaacgtg  tcaagctcc  gccccaggt  420
atgtacctc  atggctatg  cagagaca  448



<210> 6716
<211> 247
<212> PRT
<213> Rattus norvegicus
<308> P49911
<400> 6716

Met Glu Met Asp Lys Arg Ile Tyr Leu Glu Leu Arg Asn Arg Thr Pro 
  1               5                  10                  15
Ser Asp Val Lys Glu Leu Val Leu Asp Asn Cys Arg Ser Ile Glu Gly 
             20                  25                  30
Lys Ile Glu Gly Leu Thr Asp Glu Phe Glu Glu Leu Glu Phe Leu Ser 
         35                  40                  45
Thr Ile Asn Val Gly Leu Thr Ser Ile Ser Asn Leu Pro Lys Leu Asn 
     50                  55                  60
Lys Leu Lys Lys Leu Glu Leu Ser Glu Asn Arg Ile Ser Gly Asp Leu 
 65                  70                  75                  80
Glu Val Leu Ala Glu Lys Cys Pro Asn Leu Lys His Leu Asn Leu Ser 
                 85                  90                  95
Gly Asn Lys Ile Lys Asp Leu Ser Thr Ile Glu Pro Leu Lys Lys Leu 
             100                105                110
Glu Asn Leu Lys Ser Leu Asp Leu Phe Asn Cys Glu Val Thr Asn Leu 
         115                120                125
Asn Ala Tyr Arg Glu Asn Val Phe Lys Leu Leu Pro Gln Val Met Tyr 
     130                135                140
Leu Asp Gly Tyr Asp Arg Asp Asn Lys Glu Ala Pro Asp Ser Asp Val 
 145                150                155                160
Glu Gly Tyr Val Glu Asp Asp Asp Glu Glu Asp Glu Asp Glu Glu Glu 
                 165                170                175
Tyr Asp Glu Tyr Ala Gln Leu Val Glu Asp Glu Glu Glu Glu Asp Glu 
             180                185                190
Glu Glu Glu Gly Glu Glu Glu Asp Val Ser Gly Glu Glu Glu Glu Asp 
         195                200                205
Glu Glu Gly Tyr Asn Asp Gly Glu Val Asp Asp Glu Glu Asp Glu Glu 
     210                215                220
Asp Ala Ala Glu Glu Glu Gly Ser Gln Lys Arg Lys Arg Glu Pro Asp 
 225                230                235                240
Asp Glu Gly Gln Glu Asp Asp 
                 245



<210> 6717
<211> 916
<212> DNA
<213> Homo sapiens
<308> X75090
<400> 6717

gctggttga  ccttcaaag  cctaaaacg  gcggccgtg  gttcggggt  tattgattg  60
attccgccg  cgcgggagc  tctgcagag  gagagcgcg  gagatggag  tgggcagac  120
gattcattt  gagctgcgg  acaggacgc  ctctgatgt  aaagaactt  tcctggaca  180
cagtcggtc  aatgaaggc  aactcgaag  cctcacaga  gaatttgaa  aactggaat  240
cttaagtac  atcaacgta  gcctcacct  aatcgcaaa  ttaccaaag  taaacaaac  300
taagaagct  gaactaagc  ataacagag  ctcaggggg  ctggaagta  tggcagaaa  360
gtgtccgaa  ctcacgcat  taaatttaa  tggcaacaa  attaaagac  tcagcacaa  420
agagccact  aaaaagtta  aaaacctca  gagcttaga  cttttcaat  gcgaggtaa  480
caacctgaa  gactaccga  aaaatgtgt  caagctcct  ccgcaactc  catatctcg  540
cggctatga  cgggacgac  aggaggccc  tgactcgga  gctgagggc  acgtggagg  600
cctggatga  gaggaggag  atgaggatg  ggaggagta  gatgaagat  ctcaggtag  660
ggaagacga  gaggacgag  atgaggagg  ggaaggtga  gaggaggac  tgagtggag  720
ggaggagga  gatgaagaa  gttataacg  tggagaggt  gatgacgag  aagatgaag  780
agagcttgg  gaagaagaa  ggggtcaga  gcgaaaacg  gaacctgaa  atgagggag  840
agatgatga  taagtggaa  aacctattt  gaaaaattc  tattgtgat  tgactgttt  900
tacccatat  ccctct  916



<210> 6718
<211> 249
<212> PRT
<213> Homo sapiens
<308> P39687
<400> 6718

Met Glu Met Gly Arg Arg Ile His Leu Glu Leu Arg Asn Arg Thr Pro 
  1               5                  10                  15
Ser Asp Val Lys Glu Leu Val Leu Asp Asn Ser Arg Ser Asn Glu Gly 
             20                  25                  30
Lys Leu Glu Gly Leu Thr Asp Glu Phe Glu Glu Leu Glu Phe Leu Ser 
         35                  40                  45
Thr Ile Asn Val Gly Leu Thr Ser Ile Ala Asn Leu Pro Lys Leu Asn 
     50                  55                  60
Lys Leu Lys Lys Leu Glu Leu Ser Asp Asn Arg Val Ser Gly Gly Leu 
 65                  70                  75                  80
Glu Val Leu Ala Glu Lys Cys Pro Asn Leu Thr His Leu Asn Leu Ser 
                 85                  90                  95
Gly Asn Lys Ile Lys Asp Leu Ser Thr Ile Glu Pro Leu Lys Lys Leu 
             100                105                110
Glu Asn Leu Lys Ser Leu Asp Leu Phe Asn Cys Glu Val Thr Asn Leu 
         115                120                125
Asn Asp Tyr Arg Glu Asn Val Phe Lys Leu Leu Pro Gln Leu Thr Tyr 
     130                135                140
Leu Asp Gly Tyr Asp Arg Asp Asp Lys Glu Ala Pro Asp Ser Asp Ala 
 145                150                155                160
Glu Gly Tyr Val Glu Gly Leu Asp Asp Glu Glu Glu Asp Glu Asp Glu 
                 165                170                175
Glu Glu Tyr Asp Glu Asp Ala Gln Val Val Glu Asp Glu Glu Asp Glu 
             180                185                190
Asp Glu Glu Glu Glu Gly Glu Glu Glu Asp Val Ser Gly Glu Glu Glu 
         195                200                205
Glu Asp Glu Glu Gly Tyr Asn Asp Gly Glu Val Asp Asp Glu Glu Asp 
     210                215                220
Glu Glu Glu Leu Gly Glu Glu Glu Arg Gly Gln Lys Arg Lys Arg Glu 
 225                230                235                240
Pro Glu Asp Glu Gly Glu Asp Asp Asp 
                 245



<210> 6719
<211> 448
<212> DNA
<213> Rattus norvegicus
<308> AI070967
<400> 6719

cggccgcaa  ggttttttt  agagctgcg  aacaggacg  cctctgatg  gaaagagct  60
gtcctggat  actgtcggt  aattgaagg  aaaatcgaa  gcctcacgg  tgagtttga  120
gaactggaa  tcctaagta  aatcaacgt  ggcctcacc  ccatttcca  cttaccaaa  180
ttaaacaaa  tcaagaagc  tgaattaag  gaaaacaga  tctcagggg  cctggaagt  240
ttggcagag  aatgtccga  ccttaagca  ctaaattta  gtggcaaca  aataaaaga  300
ctcagcaca  tagagccgc  gaagaagtt  gagaatctc  agagcctag  cctgtttaa  360
tgtgaggtg  ccaacctga  tgcctaccg  gaaaacgtg  tcaagctcc  gccccaggt  420
atgtacctc  atggctatg  cagagaca  448



<210> 6720
<211> 247
<212> PRT
<213> Rattus norvegicus
<308> P49911
<400> 6720

Met Glu Met Asp Lys Arg Ile Tyr Leu Glu Leu Arg Asn Arg Thr Pro 
  1               5                  10                  15
Ser Asp Val Lys Glu Leu Val Leu Asp Asn Cys Arg Ser Ile Glu Gly 
             20                  25                  30
Lys Ile Glu Gly Leu Thr Asp Glu Phe Glu Glu Leu Glu Phe Leu Ser 
         35                  40                  45
Thr Ile Asn Val Gly Leu Thr Ser Ile Ser Asn Leu Pro Lys Leu Asn 
     50                  55                  60
Lys Leu Lys Lys Leu Glu Leu Ser Glu Asn Arg Ile Ser Gly Asp Leu 
 65                  70                  75                  80
Glu Val Leu Ala Glu Lys Cys Pro Asn Leu Lys His Leu Asn Leu Ser 
                 85                  90                  95
Gly Asn Lys Ile Lys Asp Leu Ser Thr Ile Glu Pro Leu Lys Lys Leu 
             100                105                110
Glu Asn Leu Lys Ser Leu Asp Leu Phe Asn Cys Glu Val Thr Asn Leu 
         115                120                125
Asn Ala Tyr Arg Glu Asn Val Phe Lys Leu Leu Pro Gln Val Met Tyr 
     130                135                140
Leu Asp Gly Tyr Asp Arg Asp Asn Lys Glu Ala Pro Asp Ser Asp Val 
 145                150                155                160
Glu Gly Tyr Val Glu Asp Asp Asp Glu Glu Asp Glu Asp Glu Glu Glu 
                 165                170                175
Tyr Asp Glu Tyr Ala Gln Leu Val Glu Asp Glu Glu Glu Glu Asp Glu 
             180                185                190
Glu Glu Glu Gly Glu Glu Glu Asp Val Ser Gly Glu Glu Glu Glu Asp 
         195                200                205
Glu Glu Gly Tyr Asn Asp Gly Glu Val Asp Asp Glu Glu Asp Glu Glu 
     210                215                220
Asp Ala Ala Glu Glu Glu Gly Ser Gln Lys Arg Lys Arg Glu Pro Asp 
 225                230                235                240
Asp Glu Gly Gln Glu Asp Asp 
                 245



<210> 6721
<211> 916
<212> DNA
<213> Homo sapiens
<308> X75090
<400> 6721

gctggttga  ccttcaaag  cctaaaacg  gcggccgtg  gttcggggt  tattgattg  60
attccgccg  cgcgggagc  tctgcagag  gagagcgcg  gagatggag  tgggcagac  120
gattcattt  gagctgcgg  acaggacgc  ctctgatgt  aaagaactt  tcctggaca  180
cagtcggtc  aatgaaggc  aactcgaag  cctcacaga  gaatttgaa  aactggaat  240
cttaagtac  atcaacgta  gcctcacct  aatcgcaaa  ttaccaaag  taaacaaac  300
taagaagct  gaactaagc  ataacagag  ctcaggggg  ctggaagta  tggcagaaa  360
gtgtccgaa  ctcacgcat  taaatttaa  tggcaacaa  attaaagac  tcagcacaa  420
agagccact  aaaaagtta  aaaacctca  gagcttaga  cttttcaat  gcgaggtaa  480
caacctgaa  gactaccga  aaaatgtgt  caagctcct  ccgcaactc  catatctcg  540
cggctatga  cgggacgac  aggaggccc  tgactcgga  gctgagggc  acgtggagg  600
cctggatga  gaggaggag  atgaggatg  ggaggagta  gatgaagat  ctcaggtag  660
ggaagacga  gaggacgag  atgaggagg  ggaaggtga  gaggaggac  tgagtggag  720
ggaggagga  gatgaagaa  gttataacg  tggagaggt  gatgacgag  aagatgaag  780
agagcttgg  gaagaagaa  ggggtcaga  gcgaaaacg  gaacctgaa  atgagggag  840
agatgatga  taagtggaa  aacctattt  gaaaaattc  tattgtgat  tgactgttt  900
tacccatat  ccctct  916



<210> 6722
<211> 249
<212> PRT
<213> Homo sapiens
<308> P39687
<400> 6722

Met Glu Met Gly Arg Arg Ile His Leu Glu Leu Arg Asn Arg Thr Pro 
  1               5                  10                  15
Ser Asp Val Lys Glu Leu Val Leu Asp Asn Ser Arg Ser Asn Glu Gly 
             20                  25                  30
Lys Leu Glu Gly Leu Thr Asp Glu Phe Glu Glu Leu Glu Phe Leu Ser 
         35                  40                  45
Thr Ile Asn Val Gly Leu Thr Ser Ile Ala Asn Leu Pro Lys Leu Asn 
     50                  55                  60
Lys Leu Lys Lys Leu Glu Leu Ser Asp Asn Arg Val Ser Gly Gly Leu 
 65                  70                  75                  80
Glu Val Leu Ala Glu Lys Cys Pro Asn Leu Thr His Leu Asn Leu Ser 
                 85                  90                  95
Gly Asn Lys Ile Lys Asp Leu Ser Thr Ile Glu Pro Leu Lys Lys Leu 
             100                105                110
Glu Asn Leu Lys Ser Leu Asp Leu Phe Asn Cys Glu Val Thr Asn Leu 
         115                120                125
Asn Asp Tyr Arg Glu Asn Val Phe Lys Leu Leu Pro Gln Leu Thr Tyr 
     130                135                140
Leu Asp Gly Tyr Asp Arg Asp Asp Lys Glu Ala Pro Asp Ser Asp Ala 
 145                150                155                160
Glu Gly Tyr Val Glu Gly Leu Asp Asp Glu Glu Glu Asp Glu Asp Glu 
                 165                170                175
Glu Glu Tyr Asp Glu Asp Ala Gln Val Val Glu Asp Glu Glu Asp Glu 
             180                185                190
Asp Glu Glu Glu Glu Gly Glu Glu Glu Asp Val Ser Gly Glu Glu Glu 
         195                200                205
Glu Asp Glu Glu Gly Tyr Asn Asp Gly Glu Val Asp Asp Glu Glu Asp 
     210                215                220
Glu Glu Glu Leu Gly Glu Glu Glu Arg Gly Gln Lys Arg Lys Arg Glu 
 225                230                235                240
Pro Glu Asp Glu Gly Glu Asp Asp Asp 
                 245



<210> 6723
<211> 465
<212> DNA
<213> Rattus norvegicus
<308> AI071299
<400> 6723

ttttttttt  tttttttga  agtttaggc  ttttaatct  cacaaaaaa  tgcaagcaa  60
ctaatatct  aggtagagt  aaatgccta  actttcaaa  caaaaggcc  aaaaaaaga  120
ctttagctg  acttccaag  aattaaatt  atgagagtt  caatccttg  gctcccctt  180
gcaatgtac  gctgttcaa  ctcaaatac  aacaacagt  gaagaaatg  tagttttct  240
tacttagcc  cgtccacgg  gttgactgt  aagactagg  ataataagc  agataactc  300
aggagaaga  gacacaaac  cactttcta  ctgcatttc  gtaccgtaa  ttcagcctc  360
atattctcg  aaccaacgc  ttaaaagaa  cacactgca  agctggtct  aagtataaa  420
ggcaaaaac  aagtacctg  tgtgtatgc  tcgtgccga  ttctt  465



<210> 6724
<211> 480
<212> PRT
<213> Rattus norvegicus
<308> O08876
<400> 6724

Met Leu Asn Phe Gly Ala Ser Leu Gln Gln Ala Ser Glu Gly Lys Met 
  1               5                  10                  15
Glu Leu Ile Ser Glu Lys Ser Lys Glu Gly Ala His Pro Trp Asp Lys 
             20                  25                  30
Ala Glu Gln Ser Asp Phe Glu Ala Val Glu Ala Leu Met Ser Met Ser 
         35                  40                  45
Cys Asp Trp Lys Ser His Phe Lys Lys Tyr Leu Glu Asn Arg Pro Val 
     50                  55                  60
Thr Pro Val Ser Asp Thr Ser Glu Glu Asp Ser Leu Leu Pro Gly Thr 
 65                  70                  75                  80
Pro Asp Leu Gln Thr Val Pro Ala Phe Cys Leu Thr Pro Pro Tyr Ser 
                 85                  90                  95
Pro Ser Asp Phe Glu Pro Ser Gln Gly Ser Asn Leu Thr Ala Pro Ala 
             100                105                110
Pro Pro Thr Gly His Phe Arg Ser Leu Ser Asp Ala Ala Lys Pro Pro 
         115                120                125
Ser Ile Ala Pro Phe Lys Glu Glu Glu Lys Ser Pro Leu Ala Ala Pro 
     130                135                140
Pro Leu Pro Lys Ala Gln Ala Thr Ser Val Ile Arg His Thr Ala Asp 
 145                150                155                160
Ala Gln Leu Cys Asn His Gln Ser Cys Pro Val Lys Ala Ala Ser Ile 
                 165                170                175
Leu Asn Tyr Gln Asp Asn Ser Phe Arg Arg Arg Thr His Ile Asn Val 
             180                185                190
Glu Ala Thr Arg Lys Asn Ile Pro Cys Ala Ala Val Ser Pro Asn Arg 
         195                200                205
Pro Lys Pro Glu Pro Ser Thr Ala Ala Asn Gly Ala Glu Lys Ala Gly 
     210                215                220
Thr Ala Pro Tyr Asp Phe Ala Val Pro Ser Ser Glu Thr Val Ile Cys 
 225                230                235                240
Arg Ser Ser Gln Pro Ala Pro Thr Ser Pro Val Gln Lys Ser Val Leu 
                 245                250                255
Met Ser Ser Pro Thr Val Ser Thr Gly Gly Val Pro Pro Leu Pro Val 
             260                265                270
Ile Cys Gln Met Val Pro Leu Pro Ala Asn Asn Ser Leu Val Thr Thr 
         275                280                285
Val Val Pro Ser Ser Pro Pro Ser Gln Pro Pro Ala Val Cys Ser Pro 
     290                295                300
Val Leu Phe Met Gly Thr Gln Val Pro Lys Gly Thr Val Met Phe Val 
 305                310                315                320
Val Pro Gln Pro Val Val Gln Ser Pro Lys Pro Pro Val Val Ser Pro 
                 325                330                335
Asn Gly Thr Arg Leu Ser Pro Ile Ala Pro Ala Pro Gly Phe Ser Pro 
             340                345                350
Ser Ala Ala Arg Val Thr Pro Gln Ile Asp Ser Ser Arg Val Arg Ser 
         355                360                365
His Ile Cys Ser His Pro Gly Cys Gly Lys Thr Tyr Phe Lys Ser Ser 
     370                375                380
His Leu Lys Ala His Val Arg Thr His Thr Gly Glu Lys Pro Phe Ser 
 385                390                395                400
Cys Ser Trp Lys Gly Cys Glu Arg Arg Phe Ala Arg Ser Asp Glu Leu 
                 405                410                415
Ser Arg His Arg Arg Thr His Thr Gly Glu Lys Lys Phe Ala Cys Pro 
             420                425                430
Met Cys Asp Arg Arg Phe Met Arg Ser Asp His Leu Thr Lys His Ala 
         435                440                445
Arg Arg His Leu Ser Ala Lys Lys Leu Pro Asn Trp Gln Met Glu Val 
     450                455                460
Ser Lys Leu Asn Asp Ile Ala Leu Pro Pro Ala Thr Ala Ser Ala Gln 
 465                470                475                480



<210> 6725
<211> 3228
<212> DNA
<213> Homo sapiens
<308> S81439
<400> 6725

gtcggtctc  gccagctag  atctccccc  ccgtccgcc  ccgcccctc  tctgcctcc  60
ccgcccgcg  ctccgcccg  gcttccctt  cctgcctcg  gccccactc  ctttcctcc  120
ctccctgtt  cccttcctg  ccttcccag  tcacgctct  tttccctgc  gcctgcctt  180
cttttttcc  ttttttgca  tggcgtctt  gggctgtta  acacacgcg  gctgtccat  240
gcagcttac  taaaggcgg  cgcgattat  caattatat  gttagcgat  tttcaagag  300
aatggctcg  tttcttagg  tttcaacac  aaggcatca  gcatttttg  aaaactagt  360
ttgagaata  taccttgca  cgtaaagaa  gttttttgg  atttttaca  aatctctac  420
ttgaccaaa  gagtctgga  agttttctt  taatggaaa  taggagaaa  ggaggaaag  480
atggaaatg  tttctgaaa  gccaaaaga  agtatgtat  cctggaaca  aactgcaga  540
aaaagtgat  ttgaagctg  agaagcact  atgtcaatg  gctgcagtt  gaagtctga  600
tttaagaaa  acgttgaaa  cagacctgt  acaccagta  ctgatttgt  agaggaaga  660
aatctgctt  cgggaacac  tgattttca  acaatccca  cattttgtt  gactccacc  720
tacagtcct  ctgactttg  accctctca  gtgtcaaat  tgatggcac  agcgccatc  780
actgtacac  tcaagtcac  ctcagatac  gccaaacct  acattgccg  acctttcaa  840
gaggaagaa  agagcccag  atctgcccc  aaactcccc  aagctcagg  aacaagtgt  900
attcgtcat  cagctgatg  ccagctatg  aaccaccag  cctgcccaa  gaaagcagc  960
agcatcctc  actatcaga  caattcttt  agaagaaga  cccacctaa  tgttgaggc  1020
gcaagaaag  acataccat  tgccgctgt  tcaccaaac  gatccaaat  tgagagaaa  1080
acagtggca  atgttgatg  gaaagcaag  gctgcactt  atgactttt  tgtgccttc  1140
tcagagacg  tcatctgca  gtctcagcc  gcccctgtg  ccccacaac  gaagtcagt  1200
ttggtctct  cacctgcag  atctgcagg  ggagtgcca  ctatgccgg  catctgcca  1260
atggttccc  ttcctgcca  caaccctgt  gtgacaaca  tcgttccca  cactcctcc  1320
agccagcca  cagctgttt  cccccctgt  gtgttcatg  gcacacaag  ccccaaagg  1380
gctgtcatg  ttgtggtac  ccagcccgt  gtgcagagt  caaagcctc  ggtggtgag  1440
ccgaatggc  ccagactct  tcccattgc  cctgctcct  ggttttccc  ttcagcagc  1500
aaagtcact  ctcagattg  ttcatcaag  ataaggagt  acatctgta  ccacccagg  1560
tgtggcaag  catacttta  aagttccca  ctgaaggcc  acacgagga  gcacacagg  1620
gaaaagcct  tcagctgta  ctggaaagg  tgtgaaagg  ggtttgccc  ttctgatga  1680
ctgtccaga  acaggcgaa  ccacacggg  gagaagaaa  ttgcgtgcc  catgtgtga  1740
cggcggttc  tgaggagtg  ccatttgac  aagcatgcc  ggcgccatc  atcagccaa  1800
aagctacca  actggcaga  ggaagtgag  aagctaaat  acattgctc  acctccaac  1860
cctgctccc  cacagtgac  gaccggaaa  tgaagagtc  gaactaact  tggtctcag  1920
gggagccag  ggtgatgta  aaatgcttc  actgcaagt  tgtggcccc  caacgtggc  1980
taaagcaga  gccccacag  ctggcacga  ggccccgtc  gggttaggt  actaaaagg  2040
cttcggcca  aggcaggtc  cagaaaggc  ggtttcatt  cttatcaca  aagagagat  2100
agaaagctt  tattccttt  aatattttt  gaaggtttc  gatgaggtc  acacaggta  2160
cacagattt  gaatctgtg  gcatatttg  tactttact  tttgctgtt  atacttgag  2220
ccaactttt  aatgtgatt  ttctaaagc  ctggtttca  gaatatgga  gctggaagg  2280
aataaacat  acggtacag  catggagat  taaaatgag  ttgtattat  acaaatatt  2340
tcatctttt  ctagagtta  cttctttat  attcctagt  tttccagtc  acatcgtgg  2400
tgtagtgat  aaatatatc  agaactatc  tttttacac  attgtgaat  tttggaatt  2460
aacgactgt  tattgctaa  agggccaaa  aattggaat  ctccttaat  taattgctt  2520
gaagcatag  tacaatttg  ttttgcatt  ttgttttga  agtttaaca  atgactgta  2580
ctaggcatt  cattatgct  tgaacttta  tttgcctgc  gtttcttgt  tagatttga  2640
aattgtata  caacgtgtt  tctgtagac  ctaagatac  ctgcacttt  tttagaaaa  2700
aaactgaag  tgaaatata  attgtaaag  agggatatt  agaatctta  ataacttct  2760
gaaaaagat  gcttatgtc  tcagcaaag  acctccatg  tatgaggat  taatgtgtg  2820
ttcattgaa  tagaaaatt  gtgaccatt  ttcacaggt  gacaaatgt  gtcctgtta  2880
tttatagga  ttttttggg  tgtggaggt  gttgggtag  aaaattatt  gaacattca  2940
ttttgttaa  agtatttct  ttttattct  ttatatagt  gatgatata  acagtggca  3000
aacaaaagt  cattgctta  aatatatag  gaaaaatgt  actatatct  cccatttaa  3060
attgttttt  tatattggg  gtagatttc  gacatcaaa  cttggaccc  tggaaaaca  3120
aagttttaa  taaaaaaaa  ccttgtgac  tacaatttg  acaatattt  ttttgttgt  3180
ctttatatc  tgtttacaa  aaagaattc  ctttggcaa  aaaaaaaa  3228



<210> 6726
<211> 480
<212> PRT
<213> Homo sapiens
<308> Q13118
<400> 6726

Met Leu Asn Phe Gly Ala Ser Leu Gln Gln Thr Ala Glu Glu Arg Met 
  1               5                  10                  15
Glu Met Ile Ser Glu Arg Pro Lys Glu Ser Met Tyr Ser Trp Asn Lys 
             20                  25                  30
Thr Ala Glu Lys Ser Asp Phe Glu Ala Val Glu Ala Leu Met Ser Met 
         35                  40                  45
Ser Cys Ser Trp Lys Ser Asp Phe Lys Lys Tyr Val Glu Asn Arg Pro 
     50                  55                  60
Val Thr Pro Val Ser Asp Leu Ser Glu Glu Glu Asn Leu Leu Pro Gly 
 65                  70                  75                  80
Thr Pro Asp Phe His Thr Ile Pro Ala Phe Cys Leu Thr Pro Pro Tyr 
                 85                  90                  95
Ser Pro Ser Asp Phe Glu Pro Ser Gln Val Ser Asn Leu Met Ala Pro 
             100                105                110
Ala Pro Ser Thr Val His Phe Lys Ser Leu Ser Asp Thr Ala Lys Pro 
         115                120                125
His Ile Ala Ala Pro Phe Lys Glu Glu Glu Lys Ser Pro Val Ser Ala 
     130                135                140
Pro Lys Leu Pro Lys Ala Gln Ala Thr Ser Val Ile Arg His Thr Ala 
 145                150                155                160
Asp Ala Gln Leu Cys Asn His Gln Thr Cys Pro Met Lys Ala Ala Ser 
                 165                170                175
Ile Leu Asn Tyr Gln Asn Asn Ser Phe Arg Arg Arg Thr His Leu Asn 
             180                185                190
Val Glu Ala Ala Arg Lys Asn Ile Pro Cys Ala Ala Val Ser Pro Asn 
         195                200                205
Arg Ser Lys Cys Glu Arg Asn Thr Val Ala Asp Val Asp Glu Lys Ala 
     210                215                220
Ser Ala Ala Leu Tyr Asp Phe Ser Val Pro Ser Ser Glu Thr Val Ile 
 225                230                235                240
Cys Arg Ser Gln Pro Ala Pro Val Ser Pro Gln Gln Lys Ser Val Leu 
                 245                250                255
Val Ser Pro Pro Ala Val Ser Ala Gly Gly Val Pro Pro Met Pro Val 
             260                265                270
Ile Cys Gln Met Val Pro Leu Pro Ala Asn Asn Pro Val Val Thr Thr 
         275                280                285
Val Val Pro Ser Thr Pro Pro Ser Gln Pro Pro Ala Val Cys Pro Pro 
     290                295                300
Val Val Phe Met Gly Thr Gln Val Pro Lys Gly Ala Val Met Phe Val 
 305                310                315                320
Val Pro Gln Pro Val Val Gln Ser Ser Lys Pro Pro Val Val Ser Pro 
                 325                330                335
Asn Gly Thr Arg Leu Ser Pro Ile Ala Pro Ala Pro Gly Phe Ser Pro 
             340                345                350
Ser Ala Ala Lys Val Thr Pro Gln Ile Asp Ser Ser Arg Ile Arg Ser 
         355                360                365
His Ile Cys Ser His Pro Gly Cys Gly Lys Thr Tyr Phe Lys Ser Ser 
     370                375                380
His Leu Lys Ala His Thr Arg Thr His Thr Gly Glu Lys Pro Phe Ser 
 385                390                395                400
Cys Ser Trp Lys Gly Cys Glu Arg Arg Phe Ala Arg Ser Asp Glu Leu 
                 405                410                415
Ser Arg His Arg Arg Thr His Thr Gly Glu Lys Lys Phe Ala Cys Pro 
             420                425                430
Met Cys Asp Arg Arg Phe Met Arg Ser Asp His Leu Thr Lys His Ala 
         435                440                445
Arg Arg His Leu Ser Ala Lys Lys Leu Pro Asn Trp Gln Met Glu Val 
     450                455                460
Ser Lys Leu Asn Asp Ile Ala Leu Pro Pro Thr Pro Ala Pro Thr Gln 
 465                470                475                480



<210> 6727
<211> 446
<212> DNA
<213> Rattus norvegicus
<308> AI071435
<400> 6727

ttttttttt  tttttttgc  cagtaagta  ttgtattgc  acaggcaga  tgcgcctgc  60
gggagctga  gccactgtc  cagtggagc  tgaagatca  ctgcagcgt  ggcagtgtg  120
cctgcaccg  tctgccatg  gagccaagt  tcagtcagg  actggggcg  tgagagctc  180
caggctgtg  gtgaacagc  gaggagggg  ccgggctgg  ctatgaagg  cacctcaga  240
gcccaggga  tggccgagg  cacactctg  tgaggcaga  tcctggcaa  ggaggctga  300
tgaggtatc  gaaagcctt  agagacatc  ggaacggga  aggggtccc  ggtgacaga  360
actgtgtga  tgcagagcc  atgggagct  tgggccctg  ggtctcaat  agaagttcg  420
cttgtgttt  ttcagctcc  ccatga  446



<210> 6728
<211> 364
<212> DNA
<213> Rattus norvegicus
<308> AI072943
<400> 6728

ttttttttt  tttttttct  tcttcactc  ttactgtgt  aaaataaac  taacaattc  60
tgtcatctc  gcaagaaaa  gggaaaaaa  aaagcgagg  taccagtat  aatagtgca  120
ttccagaat  gctgatggg  gtgggttta  ccctttgat  ctcaaaagg  tgcagattt  180
tatgaaaaa  gtacagctt  ggttagcaa  taatgaaaa  gtaagatac  tcgattctt  240
cgtatttta  aatatgtac  ttgtaacaa  atcaactct  gggggcggg  gttgctttt  300
ttttttttt  ttttggcaa  taagacaaa  ttgggactc  aagtattgg  cttgtttct  360
ctca  364



<210> 6729
<211> 432
<212> PRT
<213> Rattus norvegicus
<308> P47971
<400> 6729

Met Leu Ala Gly Arg Ala Ala Arg Thr Cys Ala Leu Leu Ala Leu Cys 
  1               5                  10                  15
Leu Leu Gly Ser Arg Ala Gln Asp Phe Gly Pro Thr Arg Phe Ile Cys 
             20                  25                  30
Thr Ser Val Pro Val Asp Ala Asp Met Cys Ala Ala Ser Val Ala Ala 
         35                  40                  45
Gly Gly Ala Glu Glu Leu Arg Ser Asn Val Leu Gln Leu Arg Glu Thr 
     50                  55                  60
Val Leu Gln Gln Lys Glu Thr Ile Leu Ser Gln Lys Glu Thr Ile Arg 
 65                  70                  75                  80
Glu Leu Thr Thr Lys Leu Gly Arg Cys Glu Ser Gln Ser Thr Leu Asp 
                 85                  90                  95
Ala Gly Pro Gly Glu Ala Arg Ser Gly Gly Gly Arg Lys Gln Pro Gly 
             100                105                110
Ser Gly Lys Asn Thr Met Gly Asp Leu Ser Arg Thr Pro Ala Ser Glu 
         115                120                125
Thr Leu Ser Gln Leu Gly Gln Thr Leu Gln Ser Leu Lys Thr Arg Leu 
     130                135                140
Glu Asn Leu Glu Gln Tyr Ser Arg Leu Asn Ser Ser Ser Gln Thr Asn 
 145                150                155                160
Ser Leu Lys Asp Leu Leu Gln Ser Lys Ile Asp Asp Leu Glu Arg Gln 
                 165                170                175
Val Leu Ser Arg Val Asn Thr Leu Glu Glu Gly Lys Gly Gly Pro Lys 
             180                185                190
Asn Asp Thr Glu Glu Arg Ala Lys Ile Glu Ser Ala Leu Thr Ser Leu 
         195                200                205
His Gln Arg Ile Ser Glu Leu Glu Lys Gly Gln Lys Asp Asn Arg Pro 
     210                215                220
Gly Asp Lys Phe Gln Leu Thr Phe Pro Leu Arg Thr Asn Tyr Met Tyr 
 225                230                235                240
Ala Lys Val Lys Lys Ser Leu Pro Glu Met Tyr Ala Phe Thr Val Cys 
                 245                250                255
Met Trp Leu Lys Ser Ser Ala Ala Pro Gly Val Gly Thr Pro Phe Ser 
             260                265                270
Tyr Ala Val Pro Gly Gln Ala Asn Glu Leu Val Leu Ile Glu Trp Gly 
         275                280                285
Asn Asn Pro Met Glu Ile Leu Ile Asn Asp Lys Val Ala Lys Leu Pro 
     290                295                300
Phe Val Ile Asn Asp Gly Lys Trp His His Ile Cys Val Thr Trp Thr 
 305                310                315                320
Thr Arg Asp Gly Val Trp Glu Ala Tyr Gln Asp Gly Thr Gln Gly Gly 
                 325                330                335
Asn Gly Glu Asn Leu Ala Pro Tyr His Pro Ile Lys Pro Gln Gly Val 
             340                345                350
Leu Val Leu Gly Gln Glu Gln Asp Thr Leu Gly Gly Gly Phe Asp Ala 
         355                360                365
Thr Gln Ala Phe Val Gly Glu Leu Ala His Phe Asn Ile Trp Asp Arg 
     370                375                380
Lys Leu Thr Pro Gly Glu Val Tyr Asn Leu Ala Thr Cys Ser Ser Lys 
 385                390                395                400
Ala Leu Ser Gly Asn Val Ile Ala Trp Ala Glu Ser Gln Ile Glu Ile 
                 405                410                415
Phe Gly Gly Ala Thr Lys Trp Thr Phe Glu Ala Cys Arg Gln Ile Asn 
             420                425                430



<210> 6730
<211> 5071
<212> DNA
<213> Homo sapiens
<308> U61849
<400> 6730

ggcctgata  cgcggcgtg  ggaccggcc  aagagcgcg  ccagagcgg  gccgtcgcg  60
gccacagcc  gagccggtc  cagccgagc  gagccccag  cgagccgag  cggcccgag  120
gctccggtg  ccgcagcca  gccggccgg  cgcgcgcgc  cctgtgcgc  gctcgccct  180
tgcctcctg  ggccccagg  tttcgggcc  acgcgcttc  tctgcactt  ggtgccggt  240
gacgccgac  tgtgtgccg  gtccgtggc  gcgggcggc  cggaggagc  ccggagcag  300
aatgtgctg  agctccggg  gaccgtgct  cagcagaag  agaccatcc  gagccagaa  360
gagaccatc  gcgagctga  cgccaagct  ggccgctgc  agagccaga  cacgctgga  420
cccggagcc  gcgaggccc  ggcgggcgg  ggccgcaag  agccgggct  gggcaagaa  480
accatgggc  acctgtccc  gacaccggc  gccgagacg  tcagccaac  cgggcaaac  540
ttgcaatcg  tcaaaaccc  cctggagaa  ctcgagcag  acagccgcc  caattcctc  600
agccagacc  acagcctca  ggatctgct  cagagcaag  tcgatgagc  ggagaggca  660
gtgctgtcc  gggtgaaca  cctggagga  ggcaagggg  ggcccaaga  cgacaccga  720
gagagggtc  agatcgaga  cgccctgac  tccctgcac  agcggatca  cgagctcga  780
aaaggtcag  aagacaacc  ccctggaga  aagttccag  tcacattcc  actgcggac  840
aactatatg  atgccaagg  gaagaagag  ctgccagag  tgtacgcct  cactgtctg  900
atgtggctc  agtccagcg  cacgccagg  gtgggcacg  ccttctcct  cgctgtgcc  960
ggccaggcc  acgagctgg  cctcattga  tggggcaac  accccatgg  gatcctcat  1020
aatgacaag  tggccaagc  gccttttgt  atcaatgat  gcaagtggc  ccacatctg  1080
gtcacctgg  ccacccggg  cggggtctg  gaggcctac  aggatggca  gcagggtgg  1140
agtggcgag  acttggcgc  ctatcaccc  atcaagccc  agggcgtgc  ggtgctggg  1200
caggagcag  acactctgg  tggtgggtt  gatgccacc  aggcatttg  gggtgagct  1260
gcccacttc  acatctggg  ccgcaagct  acccccggg  aggtgtaca  cctggccac  1320
tgcagcacc  aggctctgt  cggcaatgt  atcgcctgg  ctgaatccc  catcgagat  1380
tacggcggg  ccaccaagt  gaccttcga  gcctgtcgc  agatcaact  agcacggca  1440
gccaggctg  gccgcccgc  ctcgccccc  gcttgtgcg  cgatgatct  tttgtgcgt  1500
tcttctctc  cttttcccc  ggaatgaac  gaggccgtc  ccctgcaca  gcacacgca  1560
acagcctgg  tttgtcctc  tgcacacga  gcagcccct  ctcccatct  tccctgagg  1620
agccccact  ctctgtagg  gcccggact  tctcagcat  ccccattca  agctgaagt  1680
ggtgctgca  cgtcttgaa  aaggcagaa  ttggtgaga  gatctgtgt  tgcgtgtct  1740
catgtgtgt  tctacgtgt  tgcgtgcgt  gctggggga  gccttttct  tgaggacgt  1800
cctcatttc  ttctttctt  tggctttgg  aaaatctca  gatgaaaat  catatttgc  1860
aactttgtt  gctgcgtgc  tgctttggg  ttggtgcaa  ctcagtaca  gcatttgtc  1920
ttgtttgca  acctttctc  gagcgacat  tctttatat  gatgtaata  atgtctttt  1980
gtggtttgt  aaaggccgg  ggcgggggc  ctctacaga  aatttttat  ttgtaatag  2040
agtgaactg  ctctgaagg  gaaggcagg  cgtcctggg  tggtaccct  tgctctccc  2100
tggaggaga  gggatggct  aggacactg  cccttaccc  gggcgaaca  catccatcc  2160
tgctgtttg  atcttgaga  cagcatggg  cctgggagg  cggcctgtg  gcccagctc  2220
gctagctct  ccccaggac  gccctgccc  cgaccttcc  acctcctca  atcctgcaa  2280
gctgggtct  cccctccct  ctcacctct  gagctgtgc  gcactgctt  ccagagagg  2340
ccctgagag  ggagcgtgc  acccaccag  gaagccggg  cccagcacc  ctctccttt  2400
gcctcccgg  gtgcagacc  gaggggacc  tttaaggaa  gaagccgtg  ttcgatgaa  2460
acctggcca  atggggcac  gggacttca  cccagccca  cggtgggaa  gtccttttt  2520
ggggacttt  acagccata  ccctcccag  acaccaggc  ccaggtgag  tggttcaga  2580
ccctccagg  tactccaga  acctcacgt  tggagccag  cctggccag  caggggcct  2640
aaacccact  ctccatctc  tgggctcac  gcctacacg  gcccacaag  tgccactgg  2700
cggcgacac  gacacctga  cagtgtcca  aaccttttt  ccttttttt  ttccccgtg  2760
aaagcaaca  ggacatttc  ttctagtcc  tccaaggag  ggagagaag  gtatgtgca  2820
ttgtgtgtg  gtgtgtgtg  tgtgtgtgt  tgtgcgcta  gtgagaaag  gagcaggct  2880
gggaggccc  gcccagggt  ggaggagct  cctgctttg  accatctgg  ggtcgcacc  2940
tggagggca  cccgactct  tctccagga  tctcatcag  aaaccgctg  caagtcttt  3000
tagaaattc  actgcactg  ctggctcag  tgcacgctg  agacatttc  gcaggagga  3060
caggtgttt  tgtcttctg  tccttctag  gccacctgt  cccttaaac  caggtccac  3120
ttgtgtcaa  aacctagtg  atctgtgtg  gtctgtcag  gtctctgtg  cagtgttct  3180
gtgggtgtc  gcacggtac  ggcccgcct  ctgcaatca  cactcccgc  gagggggtg  3240
agatcaggc  ccgtgctgc  gttgttgtt  aacagtgct  tttcttaga  agcgtcttc  3300
tcagcgccc  tcggttgtg  catccttga  ctcagggat  ttctccgtt  gcatgtcct  3360
ggagtggcg  gttccttct  cctgggtcc  acatgtgtt  ccgcacctg  atggactgc  3420
ccggttctg  gttgtgtgc  gagtgccgc  cagtgttct  tgaccaccc  tgtagctac  3480
gaaaatggc  gggtaagca  gtcaagggt  ttggaggag  tcaagagag  gctcagttt  3540
cctctcccc  tccccaaac  caccaagaa  catttttaa  gtgtaggtt  agaacaagc  3600
taaaggatt  ccacagctg  gagccagca  gagagcttg  agtcgcctc  ctagaccag  3660
tctagcccc  ccctcactc  agccatctc  gagcccttg  gtaggcaac  ccggtgcgc  3720
gctgtgtgg  gtgctccct  ccagcacct  cggccagcc  cgcccctgc  gatctactg  3780
accgcagac  accttctgc  cccgtggcc  ggtgggagc  gtccgttca  gaccatgag  3840
catcctctg  cctgactag  gaggggcag  gcacacccc  gtgcttacg  ctccacccc  3900
gcagcctcc  ggcccgctc  ccttcctca  ccctcctct  acccaccca  ggtgccagg  3960
ccgaagctg  cctttagct  cctcctgcc  ttgctaggg  ctgagccaa  cccctcgac  4020
cctcactgt  ttgacactt  gcactttgc  ggccccgag  aggtcgatg  cacagccgc  4080
aatctaatc  acgtagttc  catttactc  ttaatctga  tgatgttcc  tcttgcact  4140
aataataca  gcctctctc  ggtaagcca  tttataaaa  aagaagata  aaagcactg  4200
tgaggcagt  tttgctttt  ccgagctgg  gtccgacag  tccctgggt  tccggggtg  4260
gagagctgt  gacagaagc  ctccgggcc  cagggctta  atcccactt  agtcgtaag  4320
cttcttgct  ttgataaca  agtattatt  ctcttactg  agaagaaaa  gtttattac  4380
aaacaagag  atttttatg  aagaaaagg  caaacctat  aattaactc  acctatatc  4440
cccttgaaa  tactttcag  ctccaccaa  acgtagaac  gaaagcatg  attttggaa  4500
aaagagata  attttgtat  ctttctttt  cttttgtag  ttcccagtt  attttctaa  4560
actgcaaag  tcactttgt  accagccct  ggacctgag  ccaaggggg  gtcttgtgg  4620
cagtgaggg  gtgaggaga  gctggcatg  ggttcagtc  ttccagtga  ctccaaaga  4680
gggccacct  ttctcaaaa  catgttggg  accaggagg  aaaactggc  atttatggt  4740
aacctgtgt  ttggagctg  cttactaag  ggaatgagc  gaggatttg  atatcagtt  4800
taaccttga  agaagaacc  tgggttaca  gtggttcac  ttaagagga  agaatcctt  4860
ggaatctta  ggcaaccaa  tgtggcttg  cgaagtcgt  gtttcatct  ttaaacaca  4920
tgtgtaaat  tattcaact  acgatggga  atgtattac  tctgtacac  gtggactga  4980
gtgcaattt  ttgaaaggg  acaagtcat  gaagagaaa  aaaaaaagc  caatactta  5040
agtcccaat  ttgtctcat  tgccaaaaa  a  5071



<210> 6731
<211> 430
<212> PRT
<213> Homo sapiens
<308> Q15818
<400> 6731

Met Pro Ala Gly Arg Ala Arg Thr Cys Ala Leu Leu Ala Leu Cys Leu 
  1               5                  10                  15
Leu Gly Pro Gln Asp Phe Gly Pro Thr Arg Phe Ile Cys Thr Ser Val 
             20                  25                  30
Pro Val Asp Ala Asp Met Cys Ala Ala Ser Val Ala Ala Gly Gly Ala 
         35                  40                  45
Glu Glu Leu Arg Ser Ser Asn Val Leu Gln Leu Arg Glu Thr Val Leu 
     50                  55                  60
Gln Gln Lys Glu Thr Ile Leu Ser Gln Lys Glu Thr Ile Arg Glu Leu 
 65                  70                  75                  80
Thr Ala Lys Leu Gly Arg Cys Glu Ser Gln Ser Thr Leu Asp Pro Gly 
                 85                  90                  95
Ala Gly Glu Ala Arg Ala Gly Gly Gly Arg Lys Gln Pro Gly Ser Gly 
             100                105                110
Lys Asn Thr Met Gly Asp Leu Ser Arg Thr Pro Ala Ala Glu Thr Leu 
         115                120                125
Ser Gln Leu Gly Gln Thr Leu Gln Ser Leu Lys Thr Arg Leu Glu Asn 
     130                135                140
Leu Glu Gln Tyr Ser Arg Leu Asn Ser Ser Ser Gln Thr Asn Ser Leu 
 145                150                155                160
Lys Asp Leu Leu Gln Ser Lys Ile Asp Glu Leu Glu Arg Gln Val Leu 
                 165                170                175
Ser Arg Val Asn Thr Leu Glu Glu Gly Lys Gly Gly Pro Lys Asn Asp 
             180                185                190
Thr Glu Glu Arg Val Lys Ile Glu Thr Ala Leu Thr Ser Leu His Gln 
         195                200                205
Arg Ile Ser Glu Leu Glu Lys Gly Gln Lys Asp Asn Arg Pro Gly Asp 
     210                215                220
Lys Phe Gln Leu Thr Phe Pro Leu Arg Thr Asn Tyr Met Tyr Ala Lys 
 225                230                235                240
Val Lys Lys Ser Leu Pro Glu Met Tyr Ala Phe Thr Val Cys Met Trp 
                 245                250                255
Leu Lys Ser Ser Ala Thr Pro Gly Val Gly Thr Pro Phe Ser Tyr Ala 
             260                265                270
Val Pro Gly Gln Ala Asn Glu Leu Val Leu Ile Glu Trp Gly Asn Asn 
         275                280                285
Pro Met Glu Ile Leu Ile Asn Asp Lys Val Ala Lys Leu Pro Phe Val 
     290                295                300
Ile Asn Asp Gly Lys Trp His His Ile Cys Val Thr Trp Thr Thr Arg 
 305                310                315                320
Asp Gly Val Trp Glu Ala Tyr Gln Asp Gly Thr Gln Gly Gly Ser Gly 
                 325                330                335
Glu Asn Leu Ala Pro Tyr His Pro Ile Lys Pro Gln Gly Val Leu Val 
             340                345                350
Leu Gly Gln Glu Gln Asp Thr Leu Gly Gly Gly Phe Asp Ala Thr Gln 
         355                360                365
Ala Phe Val Gly Glu Leu Ala His Phe Asn Ile Trp Asp Arg Lys Leu 
     370                375                380
Thr Pro Gly Glu Val Tyr Asn Leu Ala Thr Cys Ser Thr Lys Ala Leu 
 385                390                395                400
Ser Gly Asn Val Ile Ala Trp Ala Glu Ser His Ile Glu Ile Tyr Gly 
                 405                410                415
Gly Ala Thr Lys Trp Thr Phe Glu Ala Cys Arg Gln Ile Asn 
             420                425                430



<210> 6732
<211> 447
<212> DNA
<213> Rattus norvegicus
<308> AI073164
<400> 6732

ttttttttt  tttttttag  agcacaagg  tcttttatt  ttaatgcaa  taaaagtgg  60
aggctgaaa  agaaatccc  caaatactg  gtgttcttt  tattcaagg  ttaggcgag  120
ctttaacac  tgtgtcaaa  tctccaccc  tctctcaca  acacataca  acacgtaca  180
acacgcacg  ccacacaca  acccacaca  agctacaaa  acgaatccc  gttcaatta  240
aaagatcag  cagaagaat  caccagagt  ccatacaat  acattttac  ctatgaata  300
tggaaatta  gaggggaaa  gaaattatc  ctatatact  gctcatcaa  tcactgtcc  360
ctcttttgg  taatgcact  cacattata  taaagtctt  atactccag  aaattttta  420
ttaaaagaa  ctattacag  aaatcat  447



<210> 6733
<211> 338
<212> PRT
<213> Rattus norvegicus
<308> P56603
<400> 6733

Met Ser Asp Phe Asp Ser Asn Pro Phe Ala Asp Pro Asp Leu Asn Asn 
  1               5                  10                  15
Pro Phe Lys Asp Pro Ser Val Thr Gln Val Thr Arg Asn Val Pro Pro 
             20                  25                  30
Gly Leu Asp Glu Tyr Asn Pro Phe Ser Asp Ser Arg Thr Pro Pro Pro 
         35                  40                  45
Gly Gly Val Lys Met Pro Asn Val Pro Asn Thr Gln Pro Ala Ile Met 
     50                  55                  60
Lys Pro Thr Glu Glu His Pro Ala Tyr Thr Gln Ile Thr Lys Glu His 
 65                  70                  75                  80
Ala Leu Ala Gln Ala Glu Leu Leu Lys Arg Gln Glu Glu Leu Glu Arg 
                 85                  90                  95
Lys Ala Ala Glu Leu Asp Arg Arg Glu Arg Glu Met Gln Asn Leu Ser 
             100                105                110
Gln His Gly Arg Lys Asn Asn Trp Pro Pro Leu Pro Ser Asn Phe Pro 
         115                120                125
Val Gly Pro Cys Phe Tyr Gln Asp Phe Ser Val Asp Ile Pro Val Glu 
     130                135                140
Phe Gln Lys Thr Val Lys Leu Met Tyr Tyr Leu Trp Met Phe His Ala 
 145                150                155                160
Val Thr Leu Phe Leu Asn Ile Phe Gly Cys Leu Ala Trp Phe Cys Val 
                 165                170                175
Asp Ser Ser Arg Ala Val Asp Phe Gly Leu Ser Ile Leu Trp Phe Leu 
             180                185                190
Leu Phe Thr Pro Cys Ser Phe Val Cys Trp Tyr Arg Pro Leu Tyr Gly 
         195                200                205
Ala Phe Arg Ser Asp Ser Ser Phe Arg Phe Phe Val Phe Phe Phe Val 
     210                215                220
Tyr Ile Cys Gln Phe Ala Val His Val Leu Gln Ala Ala Gly Phe His 
 225                230                235                240
Asn Trp Gly Asn Cys Gly Trp Ile Ser Ser Leu Thr Gly Leu Asn Lys 
                 245                250                255
Asn Ile Pro Val Gly Ile Met Met Ile Ile Ile Ala Ala Leu Phe Thr 
             260                265                270
Ala Ser Ala Val Ile Ser Leu Val Met Phe Lys Lys Val His Gly Leu 
         275                280                285
Tyr Arg Thr Thr Gly Ala Ser Phe Glu Lys Ala Gln Gln Glu Phe Ala 
     290                295                300
Thr Gly Val Met Ser Asn Lys Thr Val Gln Thr Ala Ala Ala Asn Ala 
 305                310                315                320
Ala Ser Thr Ala Ala Thr Ser Ala Ala Gln Asn Ala Phe Lys Gly Asn 
                 325                330                335
Gln Met 
             340



<210> 6734
<211> 1926
<212> DNA
<213> Homo sapiens
<308> NM_004866
<400> 6734

ggggcgacg  gagcgcgca  gggggcggc  gcctcgcct  gtctctctc  ctgcgcctg  60
gtcgggtgg  tgacgccga  agccagaga  atgtcggat  tcgacagta  cccgtttgc  120
gacccggat  tcaacaatc  cttcaagga  ccatcagtt  cacaagtga  aagaaatgt  180
ccaccagga  ttgatgaat  taatccatt  tcggattct  gaacacctc  accaggcgg  240
gtgaagatg  ctaatgtac  caatacaca  ccagcaata  tgaaaccaa  agaggaaca  300
ccagcttat  cacagattg  aaaggaaca  gcattggcc  aagctgaac  tcttaagcg  360
caggaagaa  tagaaagaa  agccgcaga  ttagatcgt  gggaacgag  aatgcaaaa  420
ctcagtcaa  atggtagaa  aaataattg  ccacctctt  ctagcaatt  tcctgtcgg  480
ccttgtttc  atcaggatt  ttctgtaga  attcctgta  aattccaaa  gacagtaaa  540
cttatgtac  acttgtgga  gttccatgc  gtaacactg  ttctaaata  cttcggatg  600
ttggcttgg  tttgtgttg  ttctgcaag  gcggttgat  ttggattga  tatcctgtg  660
ttcttgctt  ttactcctt  ttcatttgt  tgttggtac  gaccacttt  tggagcttt  720
aggagtgac  gttcattta  attctttgt  ttcttcttc  tctatattt  tcagtttgc  780
gtacatgta  tccaagctg  aggatttca  aactggggc  attgtggtt  gatttcatc  840
cttactggt  tcaaccaaa  tattcctgt  ggaatcatg  tgataatca  agcagcact  900
ttcacagca  cagcagtca  ctcactagt  atgttcaaa  aagtacatg  actatatcg  960
acaacaggt  ctagttttg  gaaggccca  caggagttt  caacaggtg  gatgtccaa  1020
aaaactgtc  agaccgcag  tgcaaatgc  gcttcaact  cagcatcta  tgcagctca  1080
aatgctttc  agggtaacc  gatttaaga  tcttcaaac  atacactgt  accttttga  1140
tgtaccttt  tctccagtt  ctgtattct  caaatattt  tatgttcaa  acacacagt  1200
cagacagca  ggatatttc  tgttcactt  tgcatgggc  aaaaccagg  aaacttcct  1260
gtcttatta  tttacctaa  agtttctta  tatttcagt  ccccttgca  aaaaaatat  1320
acatgctaa  taaatattc  ccatatttt  gggggatga  attcagtga  ttatttcag  1380
ggtgaccca  tgaaaatta  taatggtac  tatgattaa  aacgcattt  atactaact  1440
cagtagttc  ttcaagaat  tttagagat  aggattgca  attggaaaa  taaaccatg  1500
ttcattcct  tttccctat  tatattgaa  gaaataggc  agcagagac  tagggattt  1560
aaattggct  gctttttag  tgtttcagt  accagtgaa  agcctatgt  cattttgta  1620
tagataatg  aaaatttgt  atctttttc  tttcttttt  ttagaatag  tgatatttt  1680
ataacaatc  ctaatttgc  tgggcacca  atttcttat  ttaaaagaa  tagtgtttt  1740
gcttctgta  tgcttatgg  tgtaggatt  aggggttaa  ggaatcaca  aaatgatat  1800
ctgcaagaa  ttcttttaa  taaaaagtt  gggggtgca  tataagaag  ttatataat  1860
tgcagtaca  tatccaaaa  agaaggtag  taatgcagt  gaaagtagt  gtaataatt  1920
cttttt  1926



<210> 6735
<211> 338
<212> PRT
<213> Homo sapiens
<308> O15126
<400> 6735

Met Ser Asp Phe Asp Ser Asn Pro Phe Ala Asp Pro Asp Leu Asn Asn 
  1               5                  10                  15
Pro Phe Lys Asp Pro Ser Val Thr Gln Val Thr Arg Asn Val Pro Pro 
             20                  25                  30
Gly Leu Asp Glu Tyr Asn Pro Phe Ser Asp Ser Arg Thr Pro Pro Pro 
         35                  40                  45
Gly Gly Val Lys Met Pro Asn Val Pro Asn Thr Gln Pro Ala Ile Met 
     50                  55                  60
Lys Pro Thr Glu Glu His Pro Ala Tyr Thr Gln Ile Ala Lys Glu His 
 65                  70                  75                  80
Ala Leu Ala Gln Ala Glu Leu Leu Lys Arg Gln Glu Glu Leu Glu Arg 
                 85                  90                  95
Lys Ala Ala Glu Leu Asp Arg Arg Glu Arg Glu Met Gln Asn Leu Ser 
             100                105                110
Gln His Gly Arg Lys Asn Asn Trp Pro Pro Leu Pro Ser Asn Phe Pro 
         115                120                125
Val Gly Pro Cys Phe Tyr Gln Asp Phe Ser Val Asp Ile Pro Val Glu 
     130                135                140
Phe Gln Lys Thr Val Lys Leu Met Tyr Tyr Leu Trp Met Phe His Ala 
 145                150                155                160
Val Thr Leu Phe Leu Asn Ile Phe Gly Cys Leu Ala Trp Phe Cys Val 
                 165                170                175
Asp Ser Ala Arg Ala Val Asp Phe Gly Leu Ser Ile Leu Trp Phe Leu 
             180                185                190
Leu Phe Thr Pro Cys Ser Phe Val Cys Trp Tyr Arg Pro Leu Tyr Gly 
         195                200                205
Ala Phe Arg Ser Asp Ser Ser Phe Arg Phe Phe Val Phe Phe Phe Val 
     210                215                220
Tyr Ile Cys Gln Phe Ala Val His Val Leu Gln Ala Ala Gly Phe His 
 225                230                235                240
Asn Trp Gly Asn Cys Gly Trp Ile Ser Ser Leu Thr Gly Leu Asn Gln 
                 245                250                255
Asn Ile Pro Val Gly Ile Met Met Ile Ile Ile Ala Ala Leu Phe Thr 
             260                265                270
Ala Ser Ala Val Ile Ser Leu Val Met Phe Lys Lys Val His Gly Leu 
         275                280                285
Tyr Arg Thr Thr Gly Ala Ser Phe Glu Lys Ala Gln Gln Glu Phe Ala 
     290                295                300
Thr Gly Val Met Ser Asn Lys Thr Val Gln Thr Ala Ala Ala Asn Ala 
 305                310                315                320
Ala Ser Thr Ala Ala Ser Ser Ala Ala Gln Asn Ala Phe Lys Gly Asn 
                 325                330                335
Gln Ile 
             340



<210> 6736
<211> 356
<212> DNA
<213> Rattus norvegicus
<308> AI073204
<400> 6736

ttttttttt  tttttttca  ttttccttt  tttaattgt  aaattgaat  ttataccaa  60
gtttaaact  aaattgggt  ttagcttga  gtgttttgg  ggagtttgc  gtaatggtt  120
tgctgtaac  tgtgtttgg  actctgctg  agggctgct  aaaagcacg  tgctggtaa  180
agtccaaca  tccgcggct  ctcattctt  ccgactcct  cctctgacg  aggttagca  240
tgaaggtgg  atggaagcc  gcatgcgtg  tcaactctt  ctcttccct  ctcctcggc  300
tccctcatc  cttcctcct  cgctcgctc  acctctttt  ttcagtcct  gtgccg  356



<210> 6737
<211> 255
<212> PRT
<213> Rattus norvegicus
<308> P42655
<400> 6737

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
  1               5                  10                  15
Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
             20                  25                  30
Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
         35                  40                  45
Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
     50                  55                  60
Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
 65                  70                  75                  80
Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                 85                  90                  95
Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
             100                105                110
Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
         115                120                125
His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
     130                135                140
Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
 145                150                155                160
Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                 165                170                175
Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
             180                185                190
Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
         195                200                205
Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
     210                215                220
Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
 225                230                235                240
Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                 245                250                255



<210> 6738
<211> 1723
<212> DNA
<213> Homo sapiens
<308> BC000179
<400> 6738

gtcgcgcag  ccctgccgg  gccgctgcc  ctatggatg  tcgagagga  ctggtgtac  60
aggcgaagc  ggccgagca  gctgagcga  acgacgaaa  ggtggagtc  atgaagaaa  120
tagcaggga  ggatgtgga  ctgacagtt  aagaaagaa  cctcctatc  gttgcatat  180
agaatgtga  tggagctag  agagcctcc  ggagaataa  cagcagcat  gaacagaaa  240
aagaaaaca  gggaggaga  gacaagcta  aaatgattc  ggaatatcg  caaatggtt  300
agactgagc  aaagttaat  tgttgtgac  ttctggatg  actggacaa  cacctcatt  360
cagcagcta  cactggcga  tccaaggtt  tctattata  aatgaaagg  gactaccac  420
ggtatctgg  agaatttgc  acaggaaac  acaggaagg  ggctgcgga  aacagccta  480
tggcttata  agctgctag  gatattgca  tgacagaac  tccaccaac  catcctatt  540
gcttaggtc  tgctctcaa  ttttccgta  tctactacg  aattcttaa  tcccctgac  600
gtgcctgca  gttggcaaa  gcagctttt  atgatgcaa  tgcagaact  gatacgctg  660
gtgaagaaa  ctataagga  tctacactt  tcatgcagt  gttacgtga  aatctgaca  720
tatggactt  agacatgca  ggtgacggt  aagagcaga  taaagaagc  ctgcaggac  780
tggaagacg  aaatcagtg  gacataagc  aacaagaga  accatctct  accaccccc  840
cctccccat  ccacccttt  gaaactccc  attgtcact  agaaccacc  aatctgact  900
ttacatttg  tctcagaat  taggttcct  ccctgttgg  ttttttttt  tttttttta  960
acagttttc  aaagttctt  aaggcaaga  tgaatttct  tggatttta  tggtcccag  1020
ttttaggtt  tttaagaca  taacaggac  acatagagg  tttttcagc  ttactgtgt  1080
gtctccgtg  cagatgtgg  aagatcacc  ttagcaaat  gaaattaca  ttgaaagcc  1140
ttagactta  aggtgatgc  agcatctaa  agagaggtt  atcacacta  agaggcata  1200
gtggtatca  ttttcattt  tctaattgt  taaactgtg  tttatacca  tgtttgcaa  1260
taattgggt  ttagcttga  atggttaaa  gtggtttgg  gagggactt  gttgtaatg  1320
ttttgctgt  aaaaatgtt  ccaactccg  tgaaatgtt  ctgaaaagc  tggtgctgg  1380
aacagttca  caatccgtg  ctgctcatt  ttgcctact  tactctccc  ctgaagcag  1440
ttagcgttg  aggtggtat  gaaaagcct  catgcctgt  caattcttt  gtttcttct  1500
cttccccct  cccctacct  cttcccctc  ctcctcccc  ccttcgctc  ctcaacctc  1560
tttgttcag  atgtgtaac  tgaagctaa  ttgtactac  ggatatctg  ctggagcca  1620
agatacaga  tctgtattg  tcttactga  acacagcat  gaattaaca  taaacttaa  1680
taaaacaaa  ctaaattaa  aatgccaaa  aaaaaaaaa  aaa  1723



<210> 6739
<211> 255
<212> PRT
<213> Homo sapiens
<308> P42655
<400> 6739

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
  1               5                  10                  15
Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
             20                  25                  30
Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
         35                  40                  45
Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
     50                  55                  60
Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
 65                  70                  75                  80
Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                 85                  90                  95
Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
             100                105                110
Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
         115                120                125
His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
     130                135                140
Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
 145                150                155                160
Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                 165                170                175
Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
             180                185                190
Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
         195                200                205
Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
     210                215                220
Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
 225                230                235                240
Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                 245                250                255



<210> 6740
<211> 364
<212> DNA
<213> Rattus norvegicus
<308> AI101103
<400> 6740

tcctggtgg  aggaggcag  agatcaggc  gatgggagg  agggagacc  ccgggaatg  60
cagctgaat  ccccacacg  aaactgggg  gcaggaatg  agggagaga  cccaagtgg  120
agaattatt  gtccatcat  acacactga  ctccaagac  cttacacac  agctggggg  180
gggagagga  ggtacaaga  gtgtggaaa  tggggtaag  gaagcaaac  agactagag  240
ggctgggag  aggcaactt  ggggtccta  ttccccaaa  gcccaagct  cccaccacc  300
gcagataat  tcgtgcaaa  aaaagtgtg  taagaggac  aatggaaac  aactctttc  360
aaaa  364



<210> 6741
<211> 115
<212> PRT
<213> Rattus norvegicus
<308> Q64357
<400> 6741

Ser Ala Thr Ala Ala Thr Val Pro Pro Ala Ala Pro Ala Gly Glu Gly 
  1               5                  10                  15
Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln 
             20                  25                  30
Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
         35                  40                  45
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
     50                  55                  60
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
 65                  70                  75                  80
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile 
                 85                  90                  95
Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr 
             100                105                110
Phe Ser Thr 
         115



<210> 6742
<211> 6885
<212> DNA
<213> Homo sapiens
<308> AF135372
<400> 6742

tcaagacca  cctggctaa  acggtgaaa  cctgtctct  ctaaaaata  aaaaaatta  60
ccgggcggg  tggtgggcg  ctgtagtcc  agctactcg  gaggctgag  gaggagaat  120
gcgtgaacc  gggaggcgg  gtttgcagt  agcagagat  gcgccattg  actccagcc  180
gggtgacag  cagagactc  gtctcaaaa  agaaaaaaa  agaaaaaaa  aaaaagaaa  240
tgtggtctc  gttgcctac  tcaccatca  cttgagtcc  acatccttt  aatgagtct  300
gggggtgtg  cctagaaaa  cattggcca  ttcccgaag  cagtacatg  agaagccaa  360
tctgagtta  gcaaataca  tatttttct  ttgttcaac  tacctctat  tgggtctcc  420
ttctacctg  ctgcaagaa  acattctct  agtcacttc  aggtgaact  cgtcatccc  480
ctccttctc  cacctccac  attgatcta  atttgggga  ttcctctga  ccacagcct  540
ggtggggtg  ggtgggaag  ggctgctgg  tgagagtcc  ctttctgag  tgaatcctc  600
tgggccctt  atctccgtg  gtcacacat  ccctcattt  tactctgct  ctgccgtcc  660
cacgatcca  tagcaatag  acgacccct  gccttgacc  tgtatctgg  gctctgtcc  720
ttccacatc  cccccaaac  agcatcaaa  gtcttgtct  gctctgcac  aggctcccc  780
cagttagtg  aggggtgtc  aactggggg  ggaagggct  cctgtgcct  cctcttcca  840
tcctccatg  cttatttat  ccctgacag  catgaaggg  tttgaactt  aaaggctgg  900
aatttggca  cttttgttc  ctgactaag  aagaggaaa  catttcaag  ccaaaaagc  960
gggagccag  atctcacag  atggatctg  gaccccccg  ggaagctgc  cttttcttt  1020
tcatcacat  agcgtgagc  cgggactgt  agtgcacaa  gaccaggga  gcggctgct  1080
ctctgaggg  gaggaagcc  agagtatct  ctcttagat  gggctgagt  cccacaccc  1140
gcacacaca  tccctgctc  ctcacctcc  acagacagc  gggaaatga  acctctggt  1200
acagagcca  tctccgggc  tctgtgggg  gcgggtggg  cactgcagt  ggggaggat  1260
tcacacccg  aggccctgg  aagccaggg  gggggaggg  ggaagctgg  tcctgtttg  1320
cttagagat  aaggccatc  gcctccctg  accttccag  gatgtagta  gcaccccca  1380
cccagggcc  aagggcctc  cctaaaatg  ctcctgcac  cttgaggct  gctttgacc  1440
cctgcactc  accaagagc  acagctccc  tgggtccca  cttctctga  aagctgggt  1500
ggagtgtat  cagctgctg  gtgtgctta  agggcctaa  ggagaccag  cagggataa  1560
ctcctatgt  atccacatc  agccattta  caaatatgg  tttagtacc  acatatgca  1620
tgtatttgg  gtccagaga  aggagggca  cggtccaag  tcacacctg  gaggcgaat  1680
cgcatgtaa  gcagcacct  gtaacctgt  cccactgtg  ctactacta  agaaaaata  1740
atgagagaa  aagaaaaaa  gcttttttt  tttttggcc  aggccctgt  cctgggacc  1800
aagcctgag  cctttcctg  agtcgggtc  ctgacctaa  cctggggca  agctaggtc  1860
tggccagtc  gcagccacc  cgtgaagca  cccctgccc  catcacccc  ggcagcctt  1920
tgccctcct  ctcggggtc  tcagctcac  ccacctcag  cgggcctgc  ccagcggtt  1980
agtacccct  gtctgaacc  taatcgtga  gcggggcag  cccctcccc  caccctgta  2040
acactcccc  gtcctccgc  ccctggact  gtttgggcg  gaagagcct  cctcatctt  2100
tcttcctac  ctcctaccc  gtggccagg  accccaggc  tcctctgag  catccacca  2160
cggtgatgg  ttgggacca  tctccccca  tcctctcca  cctagcagt  aggtccccg  2220
tctcgatac  gccccagca  ctgcactgg  cctctctga  ttcccaact  cagcccatt  2280
caagtgctg  aggcgggtc  ctaggtgct  ggacctggg  gcggggcaa  accttgggc  2340
gtgtggggt  caggctggg  ttactgggt  cacgattga  ggagtggtc  gggggttag  2400
tgtagggcc  ggctgcgtt  tgctctaag  ggcaggcgg  aggcggttt  ggggggctg  2460
ggtcagaca  ggtggggtg  cggtgggtt  ggggaagcc  cagcagccc  ccttggggt  2520
ccgcgagtg  cgagggagc  gccggggca  ggtggcgcg  ggcccgtgg  cctgcccgg  2580
acgaccccc  ccccgcagc  ccccgcagc  ccccgcccc  gcggccccg  tcgcgacgc  2640
tctcccgcg  cgccccgcc  ccgcccgca  tgcccggat  cgggtgacg  gcggccgcc  2700
tctttccgt  ccgggcagc  agcgccagt  ggagccagc  cgagcgccg  cgccatcac  2760
gccgctgcc  agtcctcca  ccgctgccc  cgccatgtg  gtcggccgc  cgccaccct  2820
accgcgctt  cctgcgccg  ccgccgccc  tggcaaccg  ccgtcggga  tgcccgggg  2880
ctcttctgc  ttccccgcg  cccggggcc  ggcccaagc  ggtgactgc  cgcgggcgg  2940
cgaggagcc  cgcgtcccg  gctggccgg  tcgggcgat  gccgcggga  ggagcggac  3000
cagtgtcct  ctgcccctc  ccgcccctg  caccgcggc  gcctgtctt  tcgggtcga  3060
ccggatcgc  tctgtgagg  cgccctcag  tgacaggcg  ggaaactga  gccgggggg  3120
cctcgctca  ggtcacgca  ctcatcggc  gcagggctg  accgagacc  gggcttaca  3180
cgggtggcc  tcctcccga  aaggaggac  ggagggacn  ggatggaca  gtggatggg  3240
ggagccctg  ctgcggggc  gggaggctg  aagccctgg  tcttaatcc  tccctgctc  3300
tcaggtctg  taccgctgc  acggccccc  ctgctgccc  ggctgggga  ggtggtccc  3360
ctgcacccc  tccaaacct  accagtaac  ggagactgc  gcagaccca  gcccaggtg  3420
atgaggtga  tgtgggggg  gtcaaaacc  gtaggaggg  ccctggggg  tggggatag  3480
tgtaggggc  cattttggt  tgggagtga  gacagttca  gcctttggg  ttgcggaca  3540
agataccat  ccccatccc  gtctccctg  cagcacgca  ttggaaggg  gctgggggt  3600
ttaatcagc  ttgctagcc  ggggtgtgc  agcctgggc  ggtgtgctc  ggtgatgga  3660
agagcgcct  aggttccat  gagggaggg  gttgctatg  catntgaga  gtcaccagc  3720
tgcccctga  gtgtgctcc  tgcatgtcc  caggtgtgc  aggcatgtt  tgtgtgtcc  3780
tggcatgtt  acctggcag  atcagggtg  atgttccat  tgtggcacg  tgggcacat  3840
tttgaggat  gccctcact  aggtgggcc  tggcacacc  ccctgcctc  tgggccctt  3900
tcccaggtg  tggacatca  gagggtgaa  gtggacaag  tcctggagc  agaccagaa  3960
ctgtcggag  tggacgacc  tgcagatgc  ctccaggcg  gggcctccc  gtttgaaac  4020
agcgcagcc  agctcaagc  caaatactg  tggaaaaac  tcaaggtaa  ggtggggac  4080
ggaaggagg  caggtgggt  aatggggta  catagtttg  cttactgat  ctcgcctct  4140
acccccaga  gatgatcat  ttgggagtg  tttgcgcca  catcctcat  atcatcata  4200
gtgagtagg  tgagaatgg  cggggccct  tccctggag  ggtttcccc  gtggattct  4260
ggttttgaa  gtcattaat  tagttttta  tcttcagcc  aaaacacat  tagctgcta  4320
tggcaattc  gattcatct  gagccaaaa  ctttgatgt  atttagcct  cattttgcc  4380
agttcttgg  agtcttgtt  acatttgga  ataggaaag  tggtgtatc  attgaggac  4440
ctttaggcc  aagagccca  tctgagaac  ctggaattg  ggagtggga  aaaggaaag  4500
accaggggc  tgagacatg  ccaggaagc  aaccacccc  ttatttgag  gcttgcggt  4560
tcagaggct  agaggatta  ggtctgtgg  ttcaaggcc  taccatgga  cggaaggga  4620
ctcagaacc  acctgtcta  ccccttgct  tgtagatgg  aaaactgag  ccaagagag  4680
gtgtcagcc  gctggggag  ggggaggat  ggagcaggg  caggcctga  acactgctt  4740
cttgttctc  ctctttctc  cccctctcc  tcttcctca  cttcttccc  tctctccac  4800
gtttacttc  gctcttaaa  ccccgagga  tctgccctg  ctagagaag  gcctctccc  4860
caaccctca  ccgttcctc  acctctcag  catatcttt  agccccccc  cccctggat  4920
cgtgtgtgt  tgtgtccgt  tgtgtgtcc  cctgtaaat  gccagctgt  atttataca  4980
atataatat  atatatatt  ggtctgttt  tagttttat  actagatga  ttttccggt  5040
gtccttaac  ccccttcct  aggttccct  cacccctct  tcttgcctt  cttcccttt  5100
cctttcttc  tgactagcc  caagtccct  catttgcat  tgctatgca  tagtccctc  5160
cctttcctt  ttcttccct  agatttagc  gatccttcc  cccaccctg  ccttccttt  5220
ctctttcct  ctcactctc  ccgtcatgc  ccctctgcc  cgccctcaa  aaaaaaaaa  5280
aaaaaaaaa  aaaaaaaaa  caccagcac  tgtccaggc  tccttaggt  catcttctt  5340
gtatccatt  ggaggctct  agactggcc  cacttggtc  taaaaatcc  aaggtcttt  5400
ggagcgtcc  gcatgttaa  tagcgtatc  ttacatact  ctatccctt  ccatttctt  5460
ttgttccat  actcttctc  caacctgtg  ttctttttt  actgaggag  tagtcccca  5520
tagttcttg  atcacattt  catttgcac  acattactc  caggtggtg  ggagcctgg  5580
cttttgggg  accaggctg  tctggtccc  agcattgcc  cctcctagc  cctctagtc  5640
agtttgcct  ccttaccct  attttccaa  cctcttgta  cctcctctc  ctcccccag  5700
ggtatgtaa  tgtcttgaa  ttcagtatg  tatgatgga  caataattc  gcccttcgg  5760
tttctccct  cattcctgc  ccccagttt  catgtgggg  actcaactg  cattcccat  5820
gggtttccc  cccatctgc  tgatccacc  cctcctccc  ccacaagat  aattgttgg  5880
cacaattga  ctcttgtag  ggggtggct  ccagtgtgt  tgtgggggt  atcactgcc  5940
tggggagga  tggggcagg  cagagaatc  ccccaattc  tgcctgaaa  ctctggcct  6000
acccctgct  ggggttgga  tgaaaaccc  cctccccaa  ttggggggt  ttgccccat  6060
actgcccag  tcctctgac  gccccccct  aatttaggg  gggggtact  gtcactgcc  6120
atgtgtgta  gggacttgc  ggaaaacgg  gatgcttgc  cctctccag  actattgag  6180
ccagagaga  ctgtcctct  attgggtga  ctgattgag  aagggtcta  tgtcttttt  6240
aatggcaca  ttttaaggg  ttgagggta  agtccctta  cctgccacg  gagggggcc  6300
ccaaacttt  ttccccccc  cacttctgg  tttctgtgt  gagggggag  agggatatc  6360
aagctgtgg  gtgaaaggg  aggagagat  ctggaggtg  gggtgctgt  ttctagacc  6420
cccatatta  cccagtgtc  cctgccccc  tcttccccc  ccccatgcc  ccaattctg  6480
ggcgcatcc  gattgtgaa  atgtacaat  aatgtgtaa  gagtaacca  gtgttgtct  6540
agatctttt  tatttttct  ttttttttt  ttggttggg  gagaataag  tcttttctt  6600
accaatggg  ataatattg  atcggaagg  ataccagga  ggttgagaa  atacattgg  6660
aatggactg  actttgcaa  aggccctga  cttgggcag  gcaaagtgt  attctcaaa  6720
tggccacag  ggggcacta  gagttggta  tgggaagtg  catagccag  ccgtgtctc  6780
aagcccggt  cgccctatg  tctagggtt  ccagctttc  tttcccttt  ctggggcat  6840
ttcctgctg  tggactcct  tctactcct  gatttaact  ctaga  6885



<210> 6743
<211> 115
<212> PRT
<213> Homo sapiens
<308> P19065
<400> 6743

Ser Ala Thr Ala Ala Thr Ala Pro Pro Ala Ala Pro Ala Gly Glu Gly 
  1               5                  10                  15
Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln 
             20                  25                  30
Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
         35                  40                  45
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
     50                  55                  60
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
 65                  70                  75                  80
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile 
                 85                  90                  95
Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr 
             100                105                110
Phe Ser Ser 
         115



<210> 6744
<211> 616
<212> DNA
<213> Rattus norvegicus
<308> AI101320
<400> 6744

tgctatgac  tggtcaatg  cttctactg  gtctgcgat  atggctgga  gggcaagac  60
tgccactca  gcgagttcc  gtgtgacgc  tacacctgc  gcaacggtg  cacatgcta  120
gacagcggc  acaccttcc  ctgcgcgtg  cccccaggc  ggaagggca  cacctgcac  180
atcgccaag  acagcagct  cgtgcccaa  ccctgtgtg  atggaggca  ctgtgtggg  240
agtggagac  ctttctcct  catctgccg  gatggctgg  agggccgca  ctgcacaca  300
aacaccaat  actgcaacc  tctgccctg  tacaacgga  gcatctgtg  ggatggcgt  360
aactggttc  gctgcgagt  tgcacctgg  tttgcgggt  ctgactgcc  tatcaacat  420
gatgagtgc  agtcctcac  ctgtgccta  ggagccacg  gtgtagatg  gatcaatgg  480
taccgctgc  gctgcccac  aggacgttc  ggccccaga  gccaggaag  ggtcatatt  540
acgaggccc  gctggtccc  gggcgtgtc  ttcccacat  ggaagttcc  gggtagaag  600
ctgcaacag  tgccgc  616



<210> 6745
<211> 1202
<212> PRT
<213> Rattus norvegicus
<308> P97607
<400> 6745

Gly Ala Cys Cys Asp Gly Asp Gly Arg Thr Thr Arg Ala Gly Gly Cys 
  1               5                  10                  15
Gly Arg Asp Glu Cys Asp Thr Tyr Val Arg Val Cys Leu Lys Glu Tyr 
             20                  25                  30
Gln Ala Lys Val Thr Pro Thr Gly Pro Cys Ser Tyr Gly Tyr Gly Ala 
         35                  40                  45
Thr Pro Val Leu Gly Ser Asn Ser Phe Tyr Leu Pro Pro Ala Gly Ala 
     50                  55                  60
Ala Gly Asp Arg Ala Arg Ala Arg Ser Arg Thr Gly Gly His Gln Asp 
 65                  70                  75                  80
Pro Gly Leu Val Val Ile Pro Phe Gln Phe Ala Trp Pro Arg Ser Phe 
                 85                  90                  95
Thr Leu Ile Val Glu Ala Trp Asp Trp Asp Asn Asp Thr Thr Pro Asp 
             100                105                110
Glu Glu Leu Leu Ile Glu Arg Val Ser His Ala Gly Met Ile Asn Pro 
         115                120                125
Glu Asp Arg Trp Lys Ser Leu His Phe Ser Gly His Val Ala His Leu 
     130                135                140
Glu Leu Gln Ile Arg Val Arg Cys Asp Glu Asn Tyr Tyr Ser Ala Thr 
 145                150                155                160
Cys Asn Lys Phe Cys Arg Pro Arg Asn Asp Phe Phe Gly His Tyr Thr 
                 165                170                175
Cys Asp Gln Tyr Gly Asn Lys Ala Cys Met Asp Gly Trp Met Gly Lys 
             180                185                190
Glu Cys Lys Glu Ala Val Cys Lys Gln Gly Cys Asn Leu Leu His Gly 
         195                200                205
Gly Cys Thr Val Pro Gly Glu Cys Arg Cys Ser Tyr Gly Trp Gln Gly 
     210                215                220
Lys Phe Cys Asp Glu Cys Val Pro Tyr Pro Gly Cys Val His Gly Ser 
 225                230                235                240
Cys Val Glu Pro Trp His Cys Asp Cys Glu Thr Asn Trp Gly Gly Leu 
                 245                250                255
Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Ser His His Pro Cys Val 
             260                265                270
Asn Gly Gly Thr Cys Ile Asn Ala Glu Pro Asp Gln Tyr Leu Cys Ala 
         275                280                285
Cys Pro Asp Gly Tyr Leu Gly Lys Asn Cys Glu Arg Ala Glu His Ala 
     290                295                300
Cys Ala Ser Asn Pro Cys Ala Asn Gly Gly Ser Cys His Glu Val Leu 
 305                310                315                320
Ser Gly Phe Glu Cys His Cys Pro Ser Gly Trp Ser Gly Pro Thr Cys 
                 325                330                335
Ala Leu Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys Ala Ala Gly Gly 
             340                345                350
Thr Cys Val Asp Gln Val Asp Gly Phe Glu Cys Ile Cys Pro Glu Gln 
         355                360                365
Trp Val Gly Ala Thr Cys Gln Leu Asp Ala Asn Glu Cys Glu Gly Lys 
     370                375                380
Pro Cys Leu Asn Ala Phe Ser Cys Lys Asn Leu Ile Gly Gly Tyr Tyr 
 385                390                395                400
Cys Asp Cys Leu Pro Gly Trp Lys Gly Ala Asn Cys His Ile Asn Ile 
                 405                410                415
Asn Asp Cys His Gly Gln Cys Gln His Gly Gly Thr Cys Lys Asp Leu 
             420                425                430
Val Asn Gly Tyr Gln Cys Val Cys Pro Arg Gly Phe Gly Gly Arg His 
         435                440                445
Cys Glu Leu Glu Tyr Tyr Lys Cys Ala Ser Ser Pro Cys Arg Arg Gly 
     450                455                460
Gly Ile Cys Glu Asp Leu Val Asp Gly Phe Arg Cys His Cys Pro Arg 
 465                470                475                480
Gly Leu Ser Gly Pro Leu Cys Glu Val Asp Val Asp Leu Trp Cys Glu 
                 485                490                495
Pro Asn Pro Cys Leu Asn Gly Ala Arg Cys Tyr Asn Leu Glu Asp Asp 
             500                505                510
Tyr Tyr Cys Ala Cys Pro Glu Asp Phe Gly Gly Lys Asn Cys Ser Val 
         515                520                525
Pro Arg Glu Thr Cys Pro Gly Gly Ala Cys Arg Val Ile Asp Gly Cys 
     530                535                540
Gly Phe Glu Ala Gly Ser Arg Ala His Gly Ala Ala Pro Ser Gly Val 
 545                550                555                560
Cys Gly Pro His Gly His Cys Val Ser Leu Pro Gly Gly Asn Phe Ser 
                 565                570                575
Cys Ile Cys Asp Ser Gly Phe Thr Gly Thr Tyr Cys His Glu Asn Ile 
             580                585                590
Asp Asp Cys Met Gly Gln Pro Cys Arg Asn Gly Gly Thr Cys Ile Asp 
         595                600                605
Glu Val Asp Ser Phe Ala Cys Phe Cys Pro Ser Gly Trp Glu Gly Glu 
     610                615                620
Leu Cys Asp Ile Asn Pro Asn Asp Cys Leu Pro Asp Pro Cys His Ser 
 625                630                635                640
Arg Gly Arg Cys Tyr Asp Leu Val Asn Asp Phe Tyr Cys Val Cys Asp 
                 645                650                655
Asp Gly Trp Lys Asp Lys Thr Cys His Ser Arg Glu Phe Gln Cys Asp 
             660                665                670
Ala Tyr Thr Cys Ser Asn Gly Gly Thr Cys Tyr Asp Ser Gly Asp Thr 
         675                680                685
Phe Arg Cys Ala Cys Pro Pro Gly Trp Lys Gly Ser Thr Cys Thr Ile 
     690                695                700
Ala Lys Asn Ser Ser Cys Val Pro Asn Pro Cys Val Asn Gly Gly Thr 
 705                710                715                720
Cys Val Gly Ser Gly Asp Ser Phe Ser Cys Ile Cys Arg Asp Gly Trp 
                 725                730                735
Glu Gly Arg Thr Cys Thr His Asn Thr Asn Asp Cys Asn Pro Leu Pro 
             740                745                750
Cys Tyr Asn Gly Gly Ile Cys Val Asp Gly Val Asn Trp Phe Arg Cys 
         755                760                765
Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp Cys Arg Ile Asn Ile Asp 
     770                775                780
Glu Cys Gln Ser Ser Pro Cys Ala Tyr Gly Ala Thr Cys Val Asp Glu 
 785                790                795                800
Ile Asn Gly Tyr Arg Cys Ser Cys Pro Pro Gly Arg Ser Gly Pro Arg 
                 805                810                815
Cys Gln Glu Val Val Ile Phe Thr Arg Pro Cys Trp Ser Arg Gly Val 
             820                825                830
Ser Phe Pro His Gly Ser Ser Trp Val Glu Asp Cys Asn Ser Cys Arg 
         835                840                845
Cys Leu Asp Gly His Arg Asp Cys Ser Lys Val Trp Cys Gly Trp Lys 
     850                855                860
Pro Cys Leu Leu Ser Pro Gln Pro Ser Ala Leu Ser Ala Gln Cys Pro 
 865                870                875                880
Pro Gly Gln Gln Cys Arg Glu Lys Ala Met Gly Gln Cys Leu Gln Pro 
                 885                890                895
Pro Cys Glu Asn Trp Gly Glu Cys Thr Ala Glu Asp Pro Leu Pro Pro 
             900                905                910
Ser Thr Pro Cys Leu Pro Arg Thr Thr His Leu Asp Asn Asn Cys Ala 
         915                920                925
Arg Leu Thr Leu His Phe Asn Arg Asp Gln Val Pro Gln Gly Thr Thr 
     930                935                940
Val Gly Ala Ile Cys Ser Gly Ile Arg Ala Leu Pro Ala Thr Arg Ala 
 945                950                955                960
Ala Ala Arg Asp Arg Leu Leu Leu Leu Leu Cys Asp Arg Ala Ser Ser 
                 965                970                975
Gly Ala Ser Ala Val Glu Val Ala Val Ser Phe Ser Pro Ala Arg Asp 
             980                985                990
Leu Pro Asp Ser Ser Leu Ile Gln Ser Thr Ala His Ala Ile Val Ala 
         995                1000                1005
Ala Ile Thr Gln Arg Gly Asn Ser Ser Leu Leu Leu Ala Val Thr Glu 
     1010                1015                1020
Val Lys Val Glu Thr Val Val Met Gly Gly Ser Ser Thr Gly Leu Leu 
 1025                1030                1035                1040
Val Pro Val Leu Cys Ser Val Phe Ser Val Leu Trp Leu Ala Cys Met 
                 1045                1050                1055
Val Ile Cys Val Trp Trp Thr Arg Lys Arg Arg Lys Glu Arg Glu Arg 
             1060                1065                1070
Ser Arg Leu Pro Arg Asp Glu Ser Ala Asn Asn Gln Trp Ala Pro Leu 
         1075                1080                1085
Asn Pro Ile Arg Asn Pro Ile Glu Arg Pro Gly Ser Ser Gly Leu Gly 
     1090                1095                1100
Thr Gly Gly His Lys Asp Val Leu Tyr Gln Cys Lys Asn Phe Thr Pro 
 1105                1110                1115                1120
Pro Pro Arg Arg Ala Gly Glu Ala Leu Pro Gly Pro Ala Ser His Gly 
                 1125                1130                1135
Ala Gly Gly Glu Asp Glu Glu Asp Glu Glu Leu Ser Arg Gly Asp Gly 
             1140                1145                1150
Arg Leu Ser Arg Ser Arg Glu Val Pro Leu Thr Gln Ile His Gln Arg 
         1155                1160                1165
Pro Gln Leu Leu Pro Gly Lys Ala Ser Leu Leu Ala Pro Gly Pro Lys 
     1170                1175                1180
Val Asp Asn Arg Ala Val Arg Ser Thr Lys Asp Val Arg Cys Ala Gly 
 1185                1190                1195                1200
Arg Glu 
                 1205



<210> 6747
<211> 1238
<212> PRT
<213> Homo sapiens
<308> Q9Y219
<400> 6747

Met Arg Ala Gln Gly Arg Gly Arg Leu Pro Arg Arg Leu Leu Leu Leu 
  1               5                  10                  15
Leu Ala Leu Trp Val Gln Ala Ala Arg Pro Met Gly Tyr Phe Glu Leu 
             20                  25                  30
Gln Leu Ser Ala Leu Arg Asn Val Asn Gly Glu Leu Leu Ser Gly Ala 
         35                  40                  45
Cys Cys Asp Gly Asp Gly Arg Thr Thr Arg Ala Gly Gly Cys Gly His 
     50                  55                  60
Asp Glu Cys Asp Thr Tyr Val Arg Val Cys Leu Lys Glu Tyr Gln Ala 
 65                  70                  75                  80
Lys Val Thr Pro Thr Gly Pro Cys Ser Tyr Gly His Gly Ala Thr Pro 
                 85                  90                  95
Val Leu Gly Gly Asn Ser Phe Tyr Leu Pro Pro Ala Gly Ala Ala Gly 
             100                105                110
Asp Arg Ala Arg Ala Arg Ala Arg Ala Gly Gly Asp Gln Asp Pro Gly 
         115                120                125
Leu Val Val Ile Pro Phe Gln Phe Ala Trp Pro Arg Ser Phe Thr Leu 
     130                135                140
Ile Val Glu Ala Trp Asp Trp Asp Asn Asp Thr Thr Pro Asn Glu Glu 
 145                150                155                160
Leu Leu Ile Glu Arg Val Ser His Ala Gly Met Ile Asn Pro Glu Asp 
                 165                170                175
Arg Trp Lys Ser Leu His Phe Ser Gly His Val Ala His Leu Glu Leu 
             180                185                190
Gln Ile Arg Val Arg Cys Asp Glu Asn Tyr Tyr Ser Ala Thr Cys Asn 
         195                200                205
Lys Phe Cys Arg Pro Arg Asn Asp Phe Phe Gly His Tyr Thr Cys Asp 
     210                215                220
Gln Tyr Gly Asn Lys Ala Cys Met Asp Gly Trp Met Gly Lys Glu Cys 
 225                230                235                240
Lys Glu Ala Val Cys Lys Gln Gly Cys Asn Leu Leu His Gly Gly Cys 
                 245                250                255
Thr Val Pro Gly Glu Cys Arg Cys Ser Tyr Gly Trp Gln Gly Arg Phe 
             260                265                270
Cys Asp Glu Cys Val Pro Tyr Pro Gly Cys Val His Gly Ser Cys Val 
         275                280                285
Glu Pro Trp Gln Cys Asn Cys Glu Thr Asn Trp Gly Gly Leu Leu Cys 
     290                295                300
Asp Lys Asp Leu Asn Tyr Cys Gly Ser His His Pro Cys Thr Asn Gly 
 305                310                315                320
Gly Thr Cys Ile Asn Ala Glu Pro Asp Gln Tyr Arg Cys Thr Cys Pro 
                 325                330                335
Asp Gly Tyr Ser Gly Arg Asn Cys Glu Lys Ala Glu His Ala Cys Thr 
             340                345                350
Ser Asn Pro Cys Ala Asn Gly Gly Ser Cys His Glu Val Pro Ser Gly 
         355                360                365
Phe Glu Cys His Cys Pro Ser Gly Trp Ser Gly Pro Thr Cys Ala Leu 
     370                375                380
Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys Ala Ala Gly Gly Thr Cys 
 385                390                395                400
Val Asp Gln Val Asp Gly Phe Glu Cys Ile Cys Pro Glu Gln Trp Val 
                 405                410                415
Gly Ala Thr Cys Gln Leu Asp Ala Asn Glu Cys Glu Gly Lys Pro Cys 
             420                425                430
Leu Asn Ala Phe Ser Cys Lys Asn Leu Ile Gly Gly Tyr Tyr Cys Asp 
         435                440                445
Cys Ile Pro Gly Trp Lys Gly Ile Asn Cys His Ile Asn Val Asn Asp 
     450                455                460
Cys Arg Gly Gln Cys Gln His Gly Gly Thr Cys Lys Asp Leu Val Asn 
 465                470                475                480
Gly Tyr Gln Cys Val Cys Pro Arg Gly Phe Gly Gly Arg His Cys Glu 
                 485                490                495
Leu Glu Arg Asp Lys Cys Ala Ser Ser Pro Cys His Ser Gly Gly Leu 
             500                505                510
Cys Glu Asp Leu Ala Asp Gly Phe His Cys His Cys Pro Gln Gly Phe 
         515                520                525
Ser Gly Pro Leu Cys Glu Val Asp Val Asp Leu Cys Glu Pro Ser Pro 
     530                535                540
Cys Arg Asn Gly Ala Arg Cys Tyr Asn Leu Glu Gly Asp Tyr Tyr Cys 
 545                550                555                560
Ala Cys Pro Asp Asp Phe Gly Gly Lys Asn Cys Ser Val Pro Arg Glu 
                 565                570                575
Pro Cys Pro Gly Gly Ala Cys Arg Val Ile Asp Gly Cys Gly Ser Asp 
             580                585                590
Ala Gly Pro Gly Met Pro Gly Thr Ala Ala Ser Gly Val Cys Gly Pro 
         595                600                605
His Gly Arg Cys Val Ser Gln Pro Gly Gly Asn Phe Ser Cys Ile Cys 
     610                615                620
Asp Ser Gly Phe Thr Gly Thr Tyr Cys His Glu Asn Ile Asp Asp Cys 
 625                630                635                640
Leu Gly Gln Pro Cys Arg Asn Gly Gly Thr Cys Ile Asp Glu Val Asp 
                 645                650                655
Ala Phe Arg Cys Phe Cys Pro Ser Gly Trp Glu Gly Glu Leu Cys Asp 
             660                665                670
Thr Asn Pro Asn Asp Cys Leu Pro Asp Pro Cys His Ser Arg Gly Arg 
         675                680                685
Cys Tyr Asp Leu Val Asn Asp Phe Tyr Cys Ala Cys Asp Asp Gly Trp 
     690                695                700
Lys Gly Lys Thr Cys His Ser Arg Glu Phe Gln Cys Asp Ala Tyr Thr 
 705                710                715                720
Cys Ser Asn Gly Gly Thr Cys Tyr Asp Ser Gly Asp Thr Phe Arg Cys 
                 725                730                735
Ala Cys Pro Pro Gly Trp Lys Gly Ser Thr Cys Ala Val Ala Lys Asn 
             740                745                750
Ser Ser Cys Leu Pro Asn Pro Cys Val Asn Gly Gly Thr Cys Val Gly 
         755                760                765
Ser Gly Ala Ser Phe Ser Cys Ile Cys Arg Asp Gly Trp Glu Gly Arg 
     770                775                780
Thr Cys Thr His Asn Thr Asn Asp Cys Asn Pro Leu Pro Cys Tyr Asn 
 785                790                795                800
Gly Gly Ile Cys Val Asp Gly Val Asn Trp Phe Arg Cys Glu Cys Ala 
                 805                810                815
Pro Gly Phe Ala Gly Pro Asp Cys Arg Ile Asn Ile Asp Glu Cys Gln 
             820                825                830
Ser Ser Pro Cys Ala Tyr Gly Ala Thr Cys Val Asp Glu Ile Asn Gly 
         835                840                845
Tyr Arg Cys Ser Cys Pro Pro Gly Arg Ala Gly Pro Arg Cys Gln Glu 
     850                855                860
Val Ile Gly Phe Gly Arg Ser Cys Trp Ser Arg Gly Thr Pro Phe Pro 
 865                870                875                880
His Gly Ser Ser Trp Val Glu Asp Cys Asn Ser Cys Arg Cys Leu Asp 
                 885                890                895
Gly Arg Arg Asp Cys Ser Lys Val Trp Cys Gly Trp Lys Pro Cys Leu 
             900                905                910
Leu Ala Gly Gln Pro Glu Ala Leu Ser Ala Gln Cys Pro Leu Gly Gln 
         915                920                925
Arg Cys Leu Glu Lys Ala Pro Gly Gln Cys Leu Arg Pro Pro Cys Glu 
     930                935                940
Ala Trp Gly Glu Cys Gly Ala Glu Glu Pro Pro Ser Thr Pro Cys Leu 
 945                950                955                960
Pro Arg Ser Gly His Leu Asp Asn Asn Cys Ala Arg Leu Thr Leu His 
                 965                970                975
Phe Asn Arg Asp His Val Pro Gln Gly Thr Thr Val Gly Ala Ile Cys 
             980                985                990
Ser Gly Ile Arg Ser Leu Pro Ala Thr Arg Ala Val Ala Arg Asp Arg 
         995                1000                1005
Leu Leu Val Leu Leu Cys Asp Arg Ala Ser Ser Gly Ala Ser Ala Val 
     1010                1015                1020
Glu Val Ala Val Ser Phe Ser Pro Ala Arg Asp Leu Pro Asp Ser Ser 
 1025                1030                1035                1040
Leu Ile Gln Gly Ala Ala His Ala Ile Val Ala Ala Ile Thr Gln Arg 
                 1045                1050                1055
Gly Asn Ser Ser Leu Leu Leu Ala Val Thr Glu Val Lys Val Glu Thr 
             1060                1065                1070
Val Val Thr Gly Gly Ser Ser Thr Gly Leu Leu Val Pro Val Leu Cys 
         1075                1080                1085
Gly Ala Phe Ser Val Leu Trp Leu Ala Cys Val Val Leu Cys Val Trp 
     1090                1095                1100
Trp Thr Arg Lys Arg Arg Lys Glu Arg Glu Arg Ser Arg Leu Pro Arg 
 1105                1110                1115                1120
Glu Glu Ser Ala Asn Asn Gln Trp Ala Pro Leu Asn Pro Ile Arg Asn 
                 1125                1130                1135
Pro Ile Glu Arg Pro Gly Gly His Lys Asp Val Leu Tyr Gln Cys Lys 
             1140                1145                1150
Asn Phe Thr Pro Pro Pro Arg Arg Ala Asp Glu Ala Leu Pro Gly Pro 
         1155                1160                1165
Ala Gly His Ala Ala Val Arg Glu Asp Glu Glu Asp Glu Asp Leu Gly 
     1170                1175                1180
Arg Gly Glu Glu Asp Ser Leu Glu Ala Glu Lys Phe Leu Ser His Lys 
 1185                1190                1195                1200
Phe Thr Lys Asp Pro Gly Arg Ser Pro Gly Arg Pro Ala His Trp Ala 
                 1205                1210                1215
Ser Gly Pro Lys Val Asp Asn Arg Ala Val Arg Ser Ile Asn Glu Ala 
             1220                1225                1230
Arg Tyr Ala Gly Lys Glu 
         1235



<210> 6748
<211> 512
<212> DNA
<213> Rattus norvegicus
<308> AI101743
<400> 6748

attaagata  agatctatg  acagaacaa  tatttgcta  ctagattac  gttccttgt  60
aaaataata  gtgaaaaat  agtagaaaa  gaaaatctg  aagttatct  aatctgaaa  120
tgttaagca  tttctgctg  acattaccg  ggatcgttt  aaagaaggc  ggagcatga  180
tgcgtagac  gaacgtaat  attctggtt  tattaaagc  cgcagtggg  ccttcagag  240
ttggcatag  ctttcagaa  catctgtag  ttctggctc  gcatgatgt  tcgactgaa  300
cgtaattgg  caccgcttt  ccgcctctc  ttcttattt  ttccacgac  ttgtctgcg  360
cagaagagc  tttcccaac  cctttgaag  cccctccta  gtcattcac  acaactaat  420
ctcctcttt  tgcaaaagc  agggcataa  ctctgccca  ccctccccc  gcgccggtg  480
ccaggacca  acgcccgtc  aacctcaga  gc  512



<210> 6749
<211> 735
<212> PRT
<213> Rattus norvegicus
<308> NP_077368
<400> 6749

Met Ala Ser Pro Leu Arg Phe Asp Gly Arg Val Val Leu Val Thr Gly 
  1               5                  10                  15
Ala Gly Gly Gly Leu Gly Arg Ala Tyr Ala Leu Ala Phe Ala Glu Arg 
             20                  25                  30
Gly Ala Leu Val Val Val Asn Asp Leu Gly Gly Asp Phe Lys Gly Val 
         35                  40                  45
Gly Lys Gly Ser Ser Ala Ala Asp Lys Val Val Glu Glu Ile Arg Arg 
     50                  55                  60
Arg Gly Gly Lys Ala Val Ala Asn Tyr Asp Ser Gly Glu Ala Gly Glu 
 65                  70                  75                  80
Lys Leu Val Lys Thr Ala Leu Asp Thr Phe Gly Arg Ile Asp Val Val 
                 85                  90                  95
Val Asn Asn Ala Gly Ile Leu Arg Asp Arg Ser Phe Ser Arg Ile Ser 
             100                105                110
Asp Glu Asp Trp Asp Ile Ile Gln Arg Val His Leu Arg Gly Ser Phe 
         115                120                125
Gln Val Thr Arg Ala Ala Trp Asp His Met Lys Lys Gln Asn Tyr Gly 
     130                135                140
Arg Ile Ile Met Thr Ala Ser Ala Ser Gly Ile Tyr Ser Asn Phe Gly 
 145                150                155                160
Gln Ala Asn Tyr Ser Ala Ala Lys Leu Gly Leu Leu Gly Leu Ala Asn 
                 165                170                175
Thr Leu Val Ile Glu Gly Arg Lys Asn Asn Ile His Cys Asn Thr Ile 
             180                185                190
Ala Pro Asn Ala Gly Ser Arg Met Thr Glu Thr Val Met Pro Glu Asp 
         195                200                205
Leu Val Glu Ala Leu Lys Pro Glu Tyr Val Ala Pro Leu Val Leu Trp 
     210                215                220
Leu Cys His Glu Ser Cys Glu Glu Asn Gly Gly Leu Phe Glu Val Gly 
 225                230                235                240
Ala Gly Trp Ile Gly Lys Leu Arg Trp Glu Arg Thr Leu Gly Ala Ile 
                 245                250                255
Val Arg Lys Arg Asn Gln Pro Met Thr Pro Glu Ala Val Arg Asp Asn 
             260                265                270
Trp Val Lys Ile Cys Asp Phe Ser Asn Ala Ser Lys Pro Lys Ser Ile 
         275                280                285
Gln Glu Ser Thr Gly Gly Ile Ile Glu Val Leu His Lys Ile Asp Ser 
     290                295                300
Glu Gly Ile Ser Gln Asn His Thr Gly Gln Val Ala Ser Ala Asp Ala 
 305                310                315                320
Ser Gly Phe Ala Gly Val Val Gly His Lys Leu Pro Ser Phe Ser Ser 
                 325                330                335
Ser Tyr Thr Glu Leu Gln Cys Ile Met Tyr Ala Leu Gly Val Gly Ala 
             340                345                350
Ser Val Lys Asn Pro Lys Asp Leu Lys Phe Val Tyr Glu Gly Ser Ala 
         355                360                365
Asp Phe Ser Cys Leu Pro Thr Phe Gly Val Ile Val Ala Gln Lys Ser 
     370                375                380
Leu Thr Ser Gly Gly Leu Ala Glu Val Pro Gly Leu Ser Ile Asn Phe 
 385                390                395                400
Ala Lys Val Leu His Gly Glu Gln Tyr Leu Glu Leu Tyr Lys Pro Leu 
                 405                410                415
Pro Arg Ser Gly Glu Leu Lys Cys Glu Ala Val Ile Ala Asp Ile Leu 
             420                425                430
Asp Lys Gly Ser Gly Ile Val Ile Val Met Asp Val Tyr Ser Tyr Ser 
         435                440                445
Gly Lys Glu Leu Ile Cys Tyr Asn Gln Phe Ser Val Phe Val Val Gly 
     450                455                460
Ser Gly Gly Phe Gly Gly Lys Arg Thr Ser Glu Lys Leu Lys Ala Ala 
 465                470                475                480
Val Ala Val Pro Asp Arg Pro Pro Asp Ala Val Leu Arg Asp Thr Thr 
                 485                490                495
Ser Leu Asn Gln Ala Ala Leu Tyr Arg Leu Ser Gly Asp Ser Asn Pro 
             500                505                510
Leu His Ile Asp Pro Ser Phe Ala Ser Ile Ala Gly Phe Glu Lys Pro 
         515                520                525
Ile Leu His Gly Leu Cys Thr Phe Gly Phe Ser Ala Arg His Val Leu 
     530                535                540
Gln Gln Phe Ala Asp Asn Asp Val Ser Arg Phe Lys Ala Ile Lys Val 
 545                550                555                560
Arg Phe Ala Lys Pro Val Tyr Pro Gly Gln Thr Leu Gln Thr Glu Met 
                 565                570                575
Trp Lys Glu Gly Asn Arg Ile His Phe Gln Thr Lys Val Gln Glu Thr 
             580                585                590
Gly Asp Ile Val Ile Ser Asn Ala Tyr Val Asp Leu Val Pro Thr Ser 
         595                600                605
Gly Val Ser Ala Gln Thr Pro Ser Glu Gly Gly Ala Leu Gln Ser Ala 
     610                615                620
Leu Val Phe Gly Glu Ile Gly Arg Arg Leu Lys Asp Val Gly Arg Glu 
 625                630                635                640
Val Val Lys Lys Val Asn Ala Val Phe Glu Trp His Ile Thr Lys Asn 
                 645                650                655
Gly Asn Val Ala Ala Lys Trp Thr Ile Asp Leu Lys Asn Gly Ser Gly 
             660                665                670
Glu Val Tyr Gln Gly Pro Ala Lys Gly Ser Ala Asp Thr Thr Ile Thr 
         675                680                685
Ile Ser Asp Glu Asp Phe Met Glu Val Val Leu Gly Lys Leu Asn Pro 
     690                695                700
Gln Asn Ala Phe Phe Ser Gly Arg Leu Lys Ala Arg Gly Asn Ile Met 
 705                710                715                720
Leu Ser Gln Lys Leu Gln Met Ile Leu Lys Asp Tyr Ala Lys Leu 
                 725                730                735



<210> 6750
<211> 2593
<212> DNA
<213> Homo sapiens
<308> NM_000414
<400> 6750

ggccagcgc  tctgcttgt  cgtgtgtgt  tcgttgcag  ccttattca  gggctcacc  60
ctgaggttc  acgggcggg  ggtactggt  accggcgcg  gggcaggat  gggccgagc  120
tatgccctg  cttttgcag  aagaggagc  ttagttgtt  tgaatgatt  gggagggga  180
ttcaaagga  ttggtaaag  ctccttagc  gctgataag  ttgttgaag  aataagaag  240
agaggtgga  aagcagtgg  caactatga  tcagtggaa  aaggagaga  ggttgtgaa  300
acagccctg  atgcttttg  aagaataga  gttgtggtc  acaatgctg  aattctgag  360
gatcgttcc  ttgctagga  aagtgatga  gactgggat  taatccaca  agttcattt  420
cggggttca  tccaagtga  acgggcagc  tgggaacac  tgaagaaac  gaagtatgg  480
aggattatt  tgacttcat  agcttcagg  atatatggc  actttggcc  ggccaatta  540
agtgctgca  agttgggtc  tctgggcct  gcaaattct  ttgcaattg  aggcaggaa  600
agcaacatt  attgtaaca  cattgctcc  aatgcggga  cacggatga  tcagacagt  660
atgcctgaa  atcttgtgg  agccctgaa  ccagagtat  tggcacctc  tgtcctttg  720
ctttgtcac  agagttgtg  ggagaatgg  ggcttgttt  aggttggag  aggatggat  780
ggaaaatta  gctgggagc  gactcttgg  gctattgta  gacaaaaga  tcacccaat  840
actcctgag  cagtcaagg  taactggaa  aagatctgt  actttgaga  tgccagcaa  900
cctcagagt  tccaagaat  aactggcag  ataattgaa  ttctgagta  aatagattc  960
gaaggagga  tttcagcaa  tcatactag  cgtgcaacg  ctacagcaa  atcaggatt  1020
gctggagct  ttggccaga  actccctcc  ttttcttat  cttatacgg  actggaagc  1080
attatgtat  cccttggag  gggagcgtc  atcaaggat  caaaagatt  gaaatttat  1140
tatgaagga  gttctgatt  ctcctgttt  cccaccttc  gagttatca  aggtcagaa  1200
tctatgatg  gtggaggat  agcagaaat  cctggactt  caatcaact  tgcaaaggt  1260
cttcatgga  agcagtact  agagttata  aaaccactt  ccagagcag  aaaattaaa  1320
tgtgaagca  ttgttgctg  tgtcctaga  aaaggatcc  gtgtagtga  tattatgga  1380
gtctattct  attctgaga  ggaacttat  tgccacaat  agttctctc  ctttcttgt  1440
ggctctgga  gctttggtg  aaaacggac  tcagacaaa  tcaaggtag  tgtagccat  1500
cctaataga  ctcctgatg  tgtacttac  gataccacc  ctcttaatc  ggctgcttt  1560
taccgcctc  gtggagact  gaatccctt  cacattgat  ctaactttg  tagtctagc  1620
ggttttgac  agcccatat  acatggatt  tgtacattt  gattttctg  caggcgtgt  1680
ttacagcag  ttgcagata  tgatgtgtc  agattcaag  caattaagg  tcgttttgc  1740
aaaccagta  atccaggac  aactctaca  actgagatg  ggaaggaag  aaacagaat  1800
cattttcaa  ccaaggtcc  agaaactgg  gacattgtc  tttcaaatg  atatgtgga  1860
cttgcacca  catctggta  ttcagctaa  acaccctct  agggcggga  gcttcagag  1920
acctttgta  ttgaggaaa  aggacgccg  ctaaaggat  ttgggcctg  ggtggtgaa  1980
aaagtaaat  ctgtatttg  gtggcatat  accaaaggc  gaaatattg  ggctaagtg  2040
actattgac  tgaaaagtg  ttctggaaa  gtgtaccaa  gccctgcaa  aggtgctgc  2100
gatacaaca  tcatacttt  agatgaaga  ttcatggag  tggtcctgg  caagcttga  2160
cctcagaag  cattcttta  tggcaggct  aaggccaga  ggaacatca  gctgagcca  2220
aaacttcag  tgattctta  agactacgc  aagctctga  gggcacact  cactattaa  2280
aaaaatgga  tcattaaat  ctctcttca  ccaaatatg  ttgattatt  tgcaaaagt  2340
attagaact  agatgcagg  gaaattgct  aacattttc  gatatcaga  aactgcaga  2400
tttcatttt  tactaattt  catgtatca  tatttttac  aggaactat  tataagcta  2460
cacatgatt  tccttctgt  cttagatct  tatcttcat  ataaaaaat  ttgcccaag  2520
cctgtttcc  tagaatttg  gatagcatt  ataagttga  aggaaaatt  aatcaataa  2580
ggcctttga  acc  2593



<210> 6751
<211> 736
<212> PRT
<213> Homo sapiens
<308> P51659
<400> 6751

Met Gly Ser Pro Leu Arg Phe Asp Gly Arg Val Val Leu Val Thr Gly 
  1               5                  10                  15
Ala Gly Ala Gly Leu Gly Arg Ala Tyr Ala Leu Ala Phe Ala Glu Arg 
             20                  25                  30
Gly Ala Leu Val Val Val Asn Asp Leu Gly Gly Asp Phe Lys Gly Val 
         35                  40                  45
Gly Lys Gly Ser Leu Ala Ala Asp Lys Val Val Glu Glu Ile Arg Arg 
     50                  55                  60
Arg Gly Gly Lys Ala Val Ala Asn Tyr Asp Ser Val Glu Glu Gly Glu 
 65                  70                  75                  80
Lys Val Val Lys Thr Ala Leu Asp Ala Phe Gly Arg Ile Asp Val Val 
                 85                  90                  95
Val Asn Asn Ala Gly Ile Leu Arg Asp Arg Ser Phe Ala Arg Ile Ser 
             100                105                110
Asp Glu Asp Trp Asp Ile Ile His Arg Val His Leu Arg Gly Ser Phe 
         115                120                125
Gln Val Thr Arg Ala Ala Trp Glu His Met Lys Lys Gln Lys Tyr Gly 
     130                135                140
Arg Ile Ile Met Thr Ser Ser Ala Ser Gly Ile Tyr Gly Asn Phe Gly 
 145                150                155                160
Gln Ala Asn Tyr Ser Ala Ala Lys Leu Gly Leu Leu Gly Leu Ala Asn 
                 165                170                175
Ser Leu Ala Ile Glu Gly Arg Lys Ser Asn Ile His Cys Asn Thr Ile 
             180                185                190
Ala Pro Asn Ala Gly Ser Arg Met Thr Gln Thr Val Met Pro Glu Asp 
         195                200                205
Leu Val Glu Ala Leu Lys Pro Glu Tyr Val Ala Pro Leu Val Leu Trp 
     210                215                220
Leu Cys His Glu Ser Cys Glu Glu Asn Gly Gly Leu Phe Glu Val Gly 
 225                230                235                240
Ala Gly Trp Ile Gly Lys Leu Arg Trp Glu Arg Thr Leu Gly Ala Ile 
                 245                250                255
Val Arg Gln Lys Asn His Pro Met Thr Pro Glu Ala Val Lys Ala Asn 
             260                265                270
Trp Lys Lys Ile Cys Asp Phe Glu Asn Ala Ser Lys Pro Gln Ser Ile 
         275                280                285
Gln Glu Ser Thr Gly Ser Ile Ile Glu Val Leu Ser Lys Ile Asp Ser 
     290                295                300
Glu Gly Gly Val Ser Ala Asn His Thr Ser Arg Ala Thr Ser Thr Ala 
 305                310                315                320
Thr Ser Gly Phe Ala Gly Ala Ile Gly Gln Lys Leu Pro Pro Phe Ser 
                 325                330                335
Tyr Ala Tyr Thr Glu Leu Glu Ala Ile Met Tyr Ala Leu Gly Val Gly 
             340                345                350
Ala Ser Ile Lys Asp Pro Lys Asp Leu Lys Phe Ile Tyr Glu Gly Ser 
         355                360                365
Ser Asp Phe Ser Cys Leu Pro Thr Phe Gly Val Ile Ile Gly Gln Lys 
     370                375                380
Ser Met Met Gly Gly Gly Leu Ala Glu Ile Pro Gly Leu Ser Ile Asn 
 385                390                395                400
Phe Ala Lys Val Leu His Gly Glu Gln Tyr Leu Glu Leu Tyr Lys Pro 
                 405                410                415
Leu Pro Arg Ala Gly Lys Leu Lys Cys Glu Ala Val Val Ala Asp Val 
             420                425                430
Leu Asp Lys Gly Ser Gly Val Val Ile Ile Met Asp Val Tyr Ser Tyr 
         435                440                445
Ser Glu Lys Glu Leu Ile Cys His Asn Gln Phe Ser Leu Phe Leu Val 
     450                455                460
Gly Ser Gly Gly Phe Gly Gly Lys Arg Thr Ser Asp Lys Val Lys Val 
 465                470                475                480
Ala Val Ala Ile Pro Asn Arg Pro Pro Asp Ala Val Leu Thr Asp Thr 
                 485                490                495
Thr Ser Leu Asn Gln Ala Ala Leu Tyr Arg Leu Ser Gly Asp Trp Asn 
             500                505                510
Pro Leu His Ile Asp Pro Asn Phe Ala Ser Leu Ala Gly Phe Asp Lys 
         515                520                525
Pro Ile Leu His Gly Leu Cys Thr Phe Gly Phe Ser Ala Arg Arg Val 
     530                535                540
Leu Gln Gln Phe Ala Asp Asn Asp Val Ser Arg Phe Lys Ala Ile Lys 
 545                550                555                560
Ala Arg Phe Ala Lys Pro Val Tyr Pro Gly Gln Thr Leu Gln Thr Glu 
                 565                570                575
Met Trp Lys Glu Gly Asn Arg Ile His Phe Gln Thr Lys Val Gln Glu 
             580                585                590
Thr Gly Asp Ile Val Ile Ser Asn Ala Tyr Val Asp Leu Ala Pro Thr 
         595                600                605
Ser Gly Thr Ser Ala Lys Thr Pro Ser Glu Gly Gly Lys Leu Gln Ser 
     610                615                620
Thr Phe Val Phe Glu Glu Ile Gly Arg Arg Leu Lys Asp Ile Gly Pro 
 625                630                635                640
Glu Val Val Lys Lys Val Asn Ala Val Phe Glu Trp His Ile Thr Lys 
                 645                650                655
Gly Gly Asn Ile Gly Ala Lys Trp Thr Ile Asp Leu Lys Ser Gly Ser 
             660                665                670
Gly Lys Val Tyr Gln Gly Pro Ala Lys Gly Ala Ala Asp Thr Thr Ile 
         675                680                685
Ile Leu Ser Asp Glu Asp Phe Met Glu Val Val Leu Gly Lys Leu Asp 
     690                695                700
Pro Gln Lys Ala Phe Phe Ser Gly Arg Leu Lys Ala Arg Gly Asn Ile 
 705                710                715                720
Met Leu Ser Gln Lys Leu Gln Met Ile Leu Lys Asp Tyr Ala Lys Leu 
                 725                730                735



<210> 6752
<211> 583
<212> DNA
<213> Rattus norvegicus
<308> AI102031
<400> 6752

ttttttttt  tgggtttgt  cggtttttc  tttttgttt  tttcgctgc  ttttgaaca  60
tagggctta  tttcaaaca  cacacggtt  gtctgcaga  cggaccagg  tgggccaca  120
tgcaggccc  gcccagggc  gctgccaga  gaggaccca  gccctgtcc  gtggcgcgg  180
caagcgtca  gcaagtgcg  cggtggctc  gcacccccg  cccgccctg  acatgcggg  240
atcgggaac  caactagga  ggggacaca  cagcttcgg  aatactgga  aagtccact  300
aactgggtc  gacggcttt  tggaaaacc  cctcatctt  gggggtaca  ctcttggct  360
aggtttccg  tccccaatt  cccgacact  ttcaagagt  tcaaaacaa  acaaaaaac  420
gaaaagaag  ggaagaaaa  caaaaaaaa  aaaagcaca  atcttttgg  aaaaggttc  480
tcacacacc  gaaggctgc  gaggctctc  cgtcactgc  cccgctctg  gaaattctc  540
gggaagacg  cgcggaatt  ctccagttc  ttgggctga  tcc  583



<210> 6753
<211> 588
<212> PRT
<213> Rattus norvegicus
<308> O08839
<400> 6753

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
  1               5                  10                  15
Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
             20                  25                  30
Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
         35                  40                  45
Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
     50                  55                  60
Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
 65                  70                  75                  80
Lys Leu Ser Glu Cys Leu Gln Glu Val Tyr Glu Pro Glu Trp Pro Gly 
                 85                  90                  95
Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
             100                105                110
Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
         115                120                125
Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
     130                135                140
Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
 145                150                155                160
Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Pro Val Ser 
                 165                170                175
Leu Leu Glu Lys Ala Ala Pro Gln Trp Cys Gln Gly Lys Leu Gln Ala 
             180                185                190
His Leu Val Ala Gln Thr Asn Leu Leu Arg Asn Gln Ala Glu Glu Glu 
         195                200                205
Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu Gln 
     210                215                220
Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val Asn 
 225                230                235                240
Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu Met 
                 245                250                255
Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Ser Leu Glu Lys 
             260                265                270
Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Ser Asp Ser 
         275                280                285
Ala Pro Glu Lys Gly Asn Lys Ser Pro Ser Pro Pro Pro Asp Gly Ser 
     290                295                300
Pro Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala 
 305                310                315                320
Ser Gly Ala Ser Pro Gly Ala Thr Ile Pro Lys Ser Pro Ser Gln Leu 
                 325                330                335
Arg Lys Gly Pro Pro Val Pro Pro Pro Pro Lys His Thr Pro Ser Lys 
             340                345                350
Glu Met Lys Gln Glu Gln Ile Leu Ser Leu Phe Asp Asp Ala Phe Val 
         355                360                365
Pro Glu Ile Ser Val Thr Thr Pro Ser Gln Phe Glu Ala Pro Gly Pro 
     370                375                380
Phe Ser Glu Gln Ala Ser Leu Leu Asp Leu Asp Phe Glu Pro Leu Pro 
 385                390                395                400
Pro Val Ala Ser Pro Val Lys Ala Pro Thr Pro Ser Gly Gln Ser Ile 
                 405                410                415
Pro Trp Asp Leu Trp Glu Pro Thr Glu Ser Gln Ala Gly Val Leu Pro 
             420                425                430
Ser Gly Glu Pro Ser Ser Ala Glu Gly Ser Phe Ala Val Ala Trp Pro 
         435                440                445
Ser Gln Thr Ala Glu Pro Gly Pro Ala Gln Pro Ala Glu Ala Ser Glu 
     450                455                460
Val Val Gly Gly Thr Gln Glu Pro Gly Glu Thr Ala Ala Ser Glu Ala 
 465                470                475                480
Thr Ser Ser Ser Leu Pro Ala Val Val Val Glu Thr Phe Ser Ala Thr 
                 485                490                495
Val Asn Gly Ala Val Glu Gly Ser Thr Thr Thr Gly Arg Leu Asp Leu 
             500                505                510
Pro Pro Gly Phe Met Phe Lys Val Gln Ala Gln His Asp Tyr Thr Ala 
         515                520                525
Thr Asp Thr Asp Glu Leu Gln Leu Lys Ala Gly Asp Val Val Leu Val 
     530                535                540
Ile Pro Phe Gln Asn Pro Glu Glu Gln Asp Glu Gly Trp Leu Met Gly 
 545                550                555                560
Val Lys Glu Ser Asp Trp Asn Gln His Lys Glu Leu Glu Lys Cys Arg 
                 565                570                575
Gly Val Phe Pro Glu Asn Phe Thr Glu Arg Val Gln 
             580                585



<210> 6754
<211> 1921
<212> DNA
<213> Homo sapiens
<308> U68485
<400> 6754

ccccgcgcg  gagcggccc  tgccaccgg  cgaggcctg  gccgcgatg  cagagatgg  60
cagtaaagg  gtgacggcg  gaaagatcg  cagcaacgt  cagaagaag  tcacccgcg  120
gcaggagaa  gttctccag  agctgggga  ggcagatga  accaaggat  agcagtttg  180
gcagtgcgt  cagaatttc  acaagcagc  gacggaggg  acccggctg  agaaggatc  240
ccggaccta  ctggcctcc  tcaaagcca  gcacgaggc  tccaagaag  tgaatgagt  300
tctgcagga  gtgtatgag  ccgattggc  cggcaggga  gaggcaaac  agatcgcag  360
gaacaacga  ctgctgtgg  tggattacc  ccagaagct  gtggaccag  cgctgctga  420
catggacac  tacctgggc  agttccccg  catcaagtc  cgcattgcc  agcgggggc  480
caagctggt  gactacgac  gtgcccggc  ccactacga  tcccttcaa  ctgccaaaa  540
gaaggatga  gccaaaatt  ccaaggccg  ggaggagct  atcaaagcc  agaaggtgt  600
tgaggagat  aatgtggat  tgcaggagg  gctgccgtc  ctgtggaac  gccgcgtag  660
tttctacgt  aacacgttc  agagcatcg  gggcctgga  gaaaacttc  acaaggaga  720
gagcaagct  aaccagaac  tcaatgatg  gctggtcgg  ctggagaag  aacacggga  780
caacacctt  acggtcaag  cccagccca  aaagaaaag  aaactgttt  cgcggctgc  840
cagaaagaa  aacagtgac  acgcgcctg  aaaagggaa  aagagccct  cgcctccag  900
tggctcccc  gccgccacc  ccgagatca  agtcaacca  gagccagag  cggccggcg  960
ggccacgcc  ggggccacc  tccccaagt  cccatctca  ccagcagag  cctcggagg  1020
ggcgggtgg  acccaacct  cggctggag  ccaggagcc  ggggagacg  cggcaagtg  1080
agcagcctc  agctctctt  ctgctgtcg  ggtggagac  ttcccagca  ctgtgaatg  1140
caccgtgga  ggcggcagt  gggccgggc  cttggacct  cccccaggt  tcatgttca  1200
ggtacaggc  cagcacgac  acacggcca  tgacacaga  gagctgcag  tcaaggctg  1260
tgatgtggt  ctggtgatc  ccttccaga  ccctgaaga  caggatgaa  gctggctca  1320
gggcgtgaa  gagagcgac  ggaaccagc  caaggagct  gagaagtgc  gtggcgtct  1380
ccccgagaa  ttcactgag  gggtcccat  acggcgggg  ccaggcagc  tccgggcgt  1440
tgaagaaca  ctcctcccg  aaaatgtgt  gttcttttt  ttgttttgt  ttcgttttt  1500
atcttttga  gagcaaagg  aaatcaaga  gagaccccc  ggcagaggg  cgttctccc  1560
aagtttagg  cgttttcca  agagccgcg  cccggcaag  ccggcggaa  tcaccagtg  1620
tcctgaagc  gctgtgtcc  ctagttgag  ttctggcgc  cctgcctgt  cccgcatgt  1680
tgcctggcc  cagggcggg  ctgggggct  ccgagccac  atacttaac  gaagcttcg  1740
ccgcaccac  cggggaagg  tcctctttt  ctggcagct  ctgtgggtg  ggcccagac  1800
ccagcctag  ctgctctgc  ccgcagacg  tctgtgtgc  gtttgaaaa  aaatcttag  1860
gttcaaaac  aaatgaaac  aaaaaaaaa  tgataaaaa  tctcaaaaa  acaaggaat  1920
c  1921



<210> 6755
<211> 593
<212> PRT
<213> Homo sapiens
<308> Q99688
<400> 6755

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
  1               5                  10                  15
Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
             20                  25                  30
Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
         35                  40                  45
Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
     50                  55                  60
Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
 65                  70                  75                  80
Lys Leu Asn Glu Cys Leu Gln Glu Val Tyr Glu Pro Asp Trp Pro Gly 
                 85                  90                  95
Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
             100                105                110
Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
         115                120                125
Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
     130                135                140
Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
 145                150                155                160
Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Pro Val Ser 
                 165                170                175
Leu Leu Glu Lys Ala Ala Pro Gln Trp Cys Gln Gly Lys Leu Gln Ala 
             180                185                190
His Leu Val Ala Gln Thr Asn Leu Leu Arg Asn Gln Ala Glu Glu Glu 
         195                200                205
Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu Gln 
     210                215                220
Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val Asn 
 225                230                235                240
Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu Met 
                 245                250                255
Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Gly Leu Glu Lys 
             260                265                270
Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Ser Asp Asn 
         275                280                285
Ala Pro Ala Lys Gly Asn Lys Ser Pro Ser Pro Pro Asp Gly Ser Pro 
     290                295                300
Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala Gly 
 305                310                315                320
Gly Ala Thr Pro Gly Ala Thr Leu Pro Lys Ser Pro Ser Gln Leu Arg 
                 325                330                335
Lys Gly Pro Pro Val Pro Pro Pro Pro Lys His Thr Pro Ser Lys Glu 
             340                345                350
Val Lys Gln Glu Gln Ile Leu Ser Leu Phe Glu Asp Thr Phe Val Pro 
         355                360                365
Glu Ile Ser Val Thr Thr Pro Ser Gln Phe Glu Ala Pro Gly Pro Phe 
     370                375                380
Ser Glu Gln Ala Ser Leu Leu Asp Leu Asp Phe Asp Pro Leu Pro Pro 
 385                390                395                400
Val Thr Ser Pro Val Lys Ala Pro Thr Pro Ser Gly Gln Ser Ile Pro 
                 405                410                415
Trp Asp Leu Trp Glu Pro Thr Glu Ser Pro Ala Gly Ser Leu Pro Ser 
             420                425                430
Gly Glu Pro Ser Ala Ala Glu Gly Thr Phe Ala Val Ser Trp Pro Ser 
         435                440                445
Gln Thr Ala Glu Pro Gly Pro Ala Gln Pro Ala Glu Ala Ser Glu Val 
     450                455                460
Ala Gly Gly Thr Gln Pro Ala Ala Gly Ala Gln Glu Pro Gly Glu Thr 
 465                470                475                480
Ala Ala Ser Glu Ala Ala Ser Ser Ser Leu Pro Ala Val Val Val Glu 
                 485                490                495
Thr Phe Pro Ala Thr Val Asn Gly Thr Val Glu Gly Gly Ser Gly Ala 
             500                505                510
Gly Arg Leu Asp Leu Pro Pro Gly Phe Met Phe Lys Val Gln Ala Gln 
         515                520                525
His Asp Tyr Thr Ala Thr Asp Thr Asp Glu Leu Gln Leu Lys Ala Gly 
     530                535                540
Asp Val Val Leu Val Ile Pro Phe Gln Asn Pro Glu Glu Gln Asp Glu 
 545                550                555                560
Gly Trp Leu Met Gly Val Lys Glu Ser Asp Trp Asn Gln His Lys Glu 
                 565                570                575
Leu Glu Lys Cys Arg Gly Val Phe Pro Glu Asn Phe Thr Glu Arg Val 
             580                585                590
Pro 
         595



<210> 6756
<211> 583
<212> DNA
<213> Rattus norvegicus
<308> AI102031
<400> 6756

ttttttttt  tgggtttgt  cggtttttc  tttttgttt  tttcgctgc  ttttgaaca  60
tagggctta  tttcaaaca  cacacggtt  gtctgcaga  cggaccagg  tgggccaca  120
tgcaggccc  gcccagggc  gctgccaga  gaggaccca  gccctgtcc  gtggcgcgg  180
caagcgtca  gcaagtgcg  cggtggctc  gcacccccg  cccgccctg  acatgcggg  240
atcgggaac  caactagga  ggggacaca  cagcttcgg  aatactgga  aagtccact  300
aactgggtc  gacggcttt  tggaaaacc  cctcatctt  gggggtaca  ctcttggct  360
aggtttccg  tccccaatt  cccgacact  ttcaagagt  tcaaaacaa  acaaaaaac  420
gaaaagaag  ggaagaaaa  caaaaaaaa  aaaagcaca  atcttttgg  aaaaggttc  480
tcacacacc  gaaggctgc  gaggctctc  cgtcactgc  cccgctctg  gaaattctc  540
gggaagacg  cgcggaatt  ctccagttc  ttgggctga  tcc  583



<210> 6757
<211> 588
<212> PRT
<213> Rattus norvegicus
<308> O08839
<400> 6757

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
  1               5                  10                  15
Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
             20                  25                  30
Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
         35                  40                  45
Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
     50                  55                  60
Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
 65                  70                  75                  80
Lys Leu Ser Glu Cys Leu Gln Glu Val Tyr Glu Pro Glu Trp Pro Gly 
                 85                  90                  95
Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
             100                105                110
Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
         115                120                125
Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
     130                135                140
Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
 145                150                155                160
Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Pro Val Ser 
                 165                170                175
Leu Leu Glu Lys Ala Ala Pro Gln Trp Cys Gln Gly Lys Leu Gln Ala 
             180                185                190
His Leu Val Ala Gln Thr Asn Leu Leu Arg Asn Gln Ala Glu Glu Glu 
         195                200                205
Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu Gln 
     210                215                220
Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val Asn 
 225                230                235                240
Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu Met 
                 245                250                255
Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Ser Leu Glu Lys 
             260                265                270
Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Ser Asp Ser 
         275                280                285
Ala Pro Glu Lys Gly Asn Lys Ser Pro Ser Pro Pro Pro Asp Gly Ser 
     290                295                300
Pro Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala 
 305                310                315                320
Ser Gly Ala Ser Pro Gly Ala Thr Ile Pro Lys Ser Pro Ser Gln Leu 
                 325                330                335
Arg Lys Gly Pro Pro Val Pro Pro Pro Pro Lys His Thr Pro Ser Lys 
             340                345                350
Glu Met Lys Gln Glu Gln Ile Leu Ser Leu Phe Asp Asp Ala Phe Val 
         355                360                365
Pro Glu Ile Ser Val Thr Thr Pro Ser Gln Phe Glu Ala Pro Gly Pro 
     370                375                380
Phe Ser Glu Gln Ala Ser Leu Leu Asp Leu Asp Phe Glu Pro Leu Pro 
 385                390                395                400
Pro Val Ala Ser Pro Val Lys Ala Pro Thr Pro Ser Gly Gln Ser Ile 
                 405                410                415
Pro Trp Asp Leu Trp Glu Pro Thr Glu Ser Gln Ala Gly Val Leu Pro 
             420                425                430
Ser Gly Glu Pro Ser Ser Ala Glu Gly Ser Phe Ala Val Ala Trp Pro 
         435                440                445
Ser Gln Thr Ala Glu Pro Gly Pro Ala Gln Pro Ala Glu Ala Ser Glu 
     450                455                460
Val Val Gly Gly Thr Gln Glu Pro Gly Glu Thr Ala Ala Ser Glu Ala 
 465                470                475                480
Thr Ser Ser Ser Leu Pro Ala Val Val Val Glu Thr Phe Ser Ala Thr 
                 485                490                495
Val Asn Gly Ala Val Glu Gly Ser Thr Thr Thr Gly Arg Leu Asp Leu 
             500                505                510
Pro Pro Gly Phe Met Phe Lys Val Gln Ala Gln His Asp Tyr Thr Ala 
         515                520                525
Thr Asp Thr Asp Glu Leu Gln Leu Lys Ala Gly Asp Val Val Leu Val 
     530                535                540
Ile Pro Phe Gln Asn Pro Glu Glu Gln Asp Glu Gly Trp Leu Met Gly 
 545                550                555                560
Val Lys Glu Ser Asp Trp Asn Gln His Lys Glu Leu Glu Lys Cys Arg 
                 565                570                575
Gly Val Phe Pro Glu Asn Phe Thr Glu Arg Val Gln 
             580                585



<210> 6758
<211> 1921
<212> DNA
<213> Homo sapiens
<308> U68485
<400> 6758

ccccgcgcg  gagcggccc  tgccaccgg  cgaggcctg  gccgcgatg  cagagatgg  60
cagtaaagg  gtgacggcg  gaaagatcg  cagcaacgt  cagaagaag  tcacccgcg  120
gcaggagaa  gttctccag  agctgggga  ggcagatga  accaaggat  agcagtttg  180
gcagtgcgt  cagaatttc  acaagcagc  gacggaggg  acccggctg  agaaggatc  240
ccggaccta  ctggcctcc  tcaaagcca  gcacgaggc  tccaagaag  tgaatgagt  300
tctgcagga  gtgtatgag  ccgattggc  cggcaggga  gaggcaaac  agatcgcag  360
gaacaacga  ctgctgtgg  tggattacc  ccagaagct  gtggaccag  cgctgctga  420
catggacac  tacctgggc  agttccccg  catcaagtc  cgcattgcc  agcgggggc  480
caagctggt  gactacgac  gtgcccggc  ccactacga  tcccttcaa  ctgccaaaa  540
gaaggatga  gccaaaatt  ccaaggccg  ggaggagct  atcaaagcc  agaaggtgt  600
tgaggagat  aatgtggat  tgcaggagg  gctgccgtc  ctgtggaac  gccgcgtag  660
tttctacgt  aacacgttc  agagcatcg  gggcctgga  gaaaacttc  acaaggaga  720
gagcaagct  aaccagaac  tcaatgatg  gctggtcgg  ctggagaag  aacacggga  780
caacacctt  acggtcaag  cccagccca  aaagaaaag  aaactgttt  cgcggctgc  840
cagaaagaa  aacagtgac  acgcgcctg  aaaagggaa  aagagccct  cgcctccag  900
tggctcccc  gccgccacc  ccgagatca  agtcaacca  gagccagag  cggccggcg  960
ggccacgcc  ggggccacc  tccccaagt  cccatctca  ccagcagag  cctcggagg  1020
ggcgggtgg  acccaacct  cggctggag  ccaggagcc  ggggagacg  cggcaagtg  1080
agcagcctc  agctctctt  ctgctgtcg  ggtggagac  ttcccagca  ctgtgaatg  1140
caccgtgga  ggcggcagt  gggccgggc  cttggacct  cccccaggt  tcatgttca  1200
ggtacaggc  cagcacgac  acacggcca  tgacacaga  gagctgcag  tcaaggctg  1260
tgatgtggt  ctggtgatc  ccttccaga  ccctgaaga  caggatgaa  gctggctca  1320
gggcgtgaa  gagagcgac  ggaaccagc  caaggagct  gagaagtgc  gtggcgtct  1380
ccccgagaa  ttcactgag  gggtcccat  acggcgggg  ccaggcagc  tccgggcgt  1440
tgaagaaca  ctcctcccg  aaaatgtgt  gttcttttt  ttgttttgt  ttcgttttt  1500
atcttttga  gagcaaagg  aaatcaaga  gagaccccc  ggcagaggg  cgttctccc  1560
aagtttagg  cgttttcca  agagccgcg  cccggcaag  ccggcggaa  tcaccagtg  1620
tcctgaagc  gctgtgtcc  ctagttgag  ttctggcgc  cctgcctgt  cccgcatgt  1680
tgcctggcc  cagggcggg  ctgggggct  ccgagccac  atacttaac  gaagcttcg  1740
ccgcaccac  cggggaagg  tcctctttt  ctggcagct  ctgtgggtg  ggcccagac  1800
ccagcctag  ctgctctgc  ccgcagacg  tctgtgtgc  gtttgaaaa  aaatcttag  1860
gttcaaaac  aaatgaaac  aaaaaaaaa  tgataaaaa  tctcaaaaa  acaaggaat  1920
c  1921



<210> 6759
<211> 593
<212> PRT
<213> Homo sapiens
<308> Q99688
<400> 6759

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
  1               5                  10                  15
Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
             20                  25                  30
Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
         35                  40                  45
Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
     50                  55                  60
Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
 65                  70                  75                  80
Lys Leu Asn Glu Cys Leu Gln Glu Val Tyr Glu Pro Asp Trp Pro Gly 
                 85                  90                  95
Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
             100                105                110
Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
         115                120                125
Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
     130                135                140
Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
 145                150                155                160
Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Pro Val Ser 
                 165                170                175
Leu Leu Glu Lys Ala Ala Pro Gln Trp Cys Gln Gly Lys Leu Gln Ala 
             180                185                190
His Leu Val Ala Gln Thr Asn Leu Leu Arg Asn Gln Ala Glu Glu Glu 
         195                200                205
Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu Gln 
     210                215                220
Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val Asn 
 225                230                235                240
Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu Met 
                 245                250                255
Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Gly Leu Glu Lys 
             260                265                270
Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Ser Asp Asn 
         275                280                285
Ala Pro Ala Lys Gly Asn Lys Ser Pro Ser Pro Pro Asp Gly Ser Pro 
     290                295                300
Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala Gly 
 305                310                315                320
Gly Ala Thr Pro Gly Ala Thr Leu Pro Lys Ser Pro Ser Gln Leu Arg 
                 325                330                335
Lys Gly Pro Pro Val Pro Pro Pro Pro Lys His Thr Pro Ser Lys Glu 
             340                345                350
Val Lys Gln Glu Gln Ile Leu Ser Leu Phe Glu Asp Thr Phe Val Pro 
         355                360                365
Glu Ile Ser Val Thr Thr Pro Ser Gln Phe Glu Ala Pro Gly Pro Phe 
     370                375                380
Ser Glu Gln Ala Ser Leu Leu Asp Leu Asp Phe Asp Pro Leu Pro Pro 
 385                390                395                400
Val Thr Ser Pro Val Lys Ala Pro Thr Pro Ser Gly Gln Ser Ile Pro 
                 405                410                415
Trp Asp Leu Trp Glu Pro Thr Glu Ser Pro Ala Gly Ser Leu Pro Ser 
             420                425                430
Gly Glu Pro Ser Ala Ala Glu Gly Thr Phe Ala Val Ser Trp Pro Ser 
         435                440                445
Gln Thr Ala Glu Pro Gly Pro Ala Gln Pro Ala Glu Ala Ser Glu Val 
     450                455                460
Ala Gly Gly Thr Gln Pro Ala Ala Gly Ala Gln Glu Pro Gly Glu Thr 
 465                470                475                480
Ala Ala Ser Glu Ala Ala Ser Ser Ser Leu Pro Ala Val Val Val Glu 
                 485                490                495
Thr Phe Pro Ala Thr Val Asn Gly Thr Val Glu Gly Gly Ser Gly Ala 
             500                505                510
Gly Arg Leu Asp Leu Pro Pro Gly Phe Met Phe Lys Val Gln Ala Gln 
         515                520                525
His Asp Tyr Thr Ala Thr Asp Thr Asp Glu Leu Gln Leu Lys Ala Gly 
     530                535                540
Asp Val Val Leu Val Ile Pro Phe Gln Asn Pro Glu Glu Gln Asp Glu 
 545                550                555                560
Gly Trp Leu Met Gly Val Lys Glu Ser Asp Trp Asn Gln His Lys Glu 
                 565                570                575
Leu Glu Lys Cys Arg Gly Val Phe Pro Glu Asn Phe Thr Glu Arg Val 
             580                585                590
Pro 
         595



<210> 6760
<211> 583
<212> DNA
<213> Rattus norvegicus
<308> AI102031
<400> 6760

ttttttttt  tgggtttgt  cggtttttc  tttttgttt  tttcgctgc  ttttgaaca  60
tagggctta  tttcaaaca  cacacggtt  gtctgcaga  cggaccagg  tgggccaca  120
tgcaggccc  gcccagggc  gctgccaga  gaggaccca  gccctgtcc  gtggcgcgg  180
caagcgtca  gcaagtgcg  cggtggctc  gcacccccg  cccgccctg  acatgcggg  240
atcgggaac  caactagga  ggggacaca  cagcttcgg  aatactgga  aagtccact  300
aactgggtc  gacggcttt  tggaaaacc  cctcatctt  gggggtaca  ctcttggct  360
aggtttccg  tccccaatt  cccgacact  ttcaagagt  tcaaaacaa  acaaaaaac  420
gaaaagaag  ggaagaaaa  caaaaaaaa  aaaagcaca  atcttttgg  aaaaggttc  480
tcacacacc  gaaggctgc  gaggctctc  cgtcactgc  cccgctctg  gaaattctc  540
gggaagacg  cgcggaatt  ctccagttc  ttgggctga  tcc  583



<210> 6761
<211> 588
<212> PRT
<213> Rattus norvegicus
<308> O08839
<400> 6761

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
  1               5                  10                  15
Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
             20                  25                  30
Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
         35                  40                  45
Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
     50                  55                  60
Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
 65                  70                  75                  80
Lys Leu Ser Glu Cys Leu Gln Glu Val Tyr Glu Pro Glu Trp Pro Gly 
                 85                  90                  95
Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
             100                105                110
Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
         115                120                125
Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
     130                135                140
Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
 145                150                155                160
Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Pro Val Ser 
                 165                170                175
Leu Leu Glu Lys Ala Ala Pro Gln Trp Cys Gln Gly Lys Leu Gln Ala 
             180                185                190
His Leu Val Ala Gln Thr Asn Leu Leu Arg Asn Gln Ala Glu Glu Glu 
         195                200                205
Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu Gln 
     210                215                220
Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val Asn 
 225                230                235                240
Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu Met 
                 245                250                255
Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Ser Leu Glu Lys 
             260                265                270
Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Ser Asp Ser 
         275                280                285
Ala Pro Glu Lys Gly Asn Lys Ser Pro Ser Pro Pro Pro Asp Gly Ser 
     290                295                300
Pro Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala 
 305                310                315                320
Ser Gly Ala Ser Pro Gly Ala Thr Ile Pro Lys Ser Pro Ser Gln Leu 
                 325                330                335
Arg Lys Gly Pro Pro Val Pro Pro Pro Pro Lys His Thr Pro Ser Lys 
             340                345                350
Glu Met Lys Gln Glu Gln Ile Leu Ser Leu Phe Asp Asp Ala Phe Val 
         355                360                365
Pro Glu Ile Ser Val Thr Thr Pro Ser Gln Phe Glu Ala Pro Gly Pro 
     370                375                380
Phe Ser Glu Gln Ala Ser Leu Leu Asp Leu Asp Phe Glu Pro Leu Pro 
 385                390                395                400
Pro Val Ala Ser Pro Val Lys Ala Pro Thr Pro Ser Gly Gln Ser Ile 
                 405                410                415
Pro Trp Asp Leu Trp Glu Pro Thr Glu Ser Gln Ala Gly Val Leu Pro 
             420                425                430
Ser Gly Glu Pro Ser Ser Ala Glu Gly Ser Phe Ala Val Ala Trp Pro 
         435                440                445
Ser Gln Thr Ala Glu Pro Gly Pro Ala Gln Pro Ala Glu Ala Ser Glu 
     450                455                460
Val Val Gly Gly Thr Gln Glu Pro Gly Glu Thr Ala Ala Ser Glu Ala 
 465                470                475                480
Thr Ser Ser Ser Leu Pro Ala Val Val Val Glu Thr Phe Ser Ala Thr 
                 485                490                495
Val Asn Gly Ala Val Glu Gly Ser Thr Thr Thr Gly Arg Leu Asp Leu 
             500                505                510
Pro Pro Gly Phe Met Phe Lys Val Gln Ala Gln His Asp Tyr Thr Ala 
         515                520                525
Thr Asp Thr Asp Glu Leu Gln Leu Lys Ala Gly Asp Val Val Leu Val 
     530                535                540
Ile Pro Phe Gln Asn Pro Glu Glu Gln Asp Glu Gly Trp Leu Met Gly 
 545                550                555                560
Val Lys Glu Ser Asp Trp Asn Gln His Lys Glu Leu Glu Lys Cys Arg 
                 565                570                575
Gly Val Phe Pro Glu Asn Phe Thr Glu Arg Val Gln 
             580                585



<210> 6762
<211> 1921
<212> DNA
<213> Homo sapiens
<308> U68485
<400> 6762

ccccgcgcg  gagcggccc  tgccaccgg  cgaggcctg  gccgcgatg  cagagatgg  60
cagtaaagg  gtgacggcg  gaaagatcg  cagcaacgt  cagaagaag  tcacccgcg  120
gcaggagaa  gttctccag  agctgggga  ggcagatga  accaaggat  agcagtttg  180
gcagtgcgt  cagaatttc  acaagcagc  gacggaggg  acccggctg  agaaggatc  240
ccggaccta  ctggcctcc  tcaaagcca  gcacgaggc  tccaagaag  tgaatgagt  300
tctgcagga  gtgtatgag  ccgattggc  cggcaggga  gaggcaaac  agatcgcag  360
gaacaacga  ctgctgtgg  tggattacc  ccagaagct  gtggaccag  cgctgctga  420
catggacac  tacctgggc  agttccccg  catcaagtc  cgcattgcc  agcgggggc  480
caagctggt  gactacgac  gtgcccggc  ccactacga  tcccttcaa  ctgccaaaa  540
gaaggatga  gccaaaatt  ccaaggccg  ggaggagct  atcaaagcc  agaaggtgt  600
tgaggagat  aatgtggat  tgcaggagg  gctgccgtc  ctgtggaac  gccgcgtag  660
tttctacgt  aacacgttc  agagcatcg  gggcctgga  gaaaacttc  acaaggaga  720
gagcaagct  aaccagaac  tcaatgatg  gctggtcgg  ctggagaag  aacacggga  780
caacacctt  acggtcaag  cccagccca  aaagaaaag  aaactgttt  cgcggctgc  840
cagaaagaa  aacagtgac  acgcgcctg  aaaagggaa  aagagccct  cgcctccag  900
tggctcccc  gccgccacc  ccgagatca  agtcaacca  gagccagag  cggccggcg  960
ggccacgcc  ggggccacc  tccccaagt  cccatctca  ccagcagag  cctcggagg  1020
ggcgggtgg  acccaacct  cggctggag  ccaggagcc  ggggagacg  cggcaagtg  1080
agcagcctc  agctctctt  ctgctgtcg  ggtggagac  ttcccagca  ctgtgaatg  1140
caccgtgga  ggcggcagt  gggccgggc  cttggacct  cccccaggt  tcatgttca  1200
ggtacaggc  cagcacgac  acacggcca  tgacacaga  gagctgcag  tcaaggctg  1260
tgatgtggt  ctggtgatc  ccttccaga  ccctgaaga  caggatgaa  gctggctca  1320
gggcgtgaa  gagagcgac  ggaaccagc  caaggagct  gagaagtgc  gtggcgtct  1380
ccccgagaa  ttcactgag  gggtcccat  acggcgggg  ccaggcagc  tccgggcgt  1440
tgaagaaca  ctcctcccg  aaaatgtgt  gttcttttt  ttgttttgt  ttcgttttt  1500
atcttttga  gagcaaagg  aaatcaaga  gagaccccc  ggcagaggg  cgttctccc  1560
aagtttagg  cgttttcca  agagccgcg  cccggcaag  ccggcggaa  tcaccagtg  1620
tcctgaagc  gctgtgtcc  ctagttgag  ttctggcgc  cctgcctgt  cccgcatgt  1680
tgcctggcc  cagggcggg  ctgggggct  ccgagccac  atacttaac  gaagcttcg  1740
ccgcaccac  cggggaagg  tcctctttt  ctggcagct  ctgtgggtg  ggcccagac  1800
ccagcctag  ctgctctgc  ccgcagacg  tctgtgtgc  gtttgaaaa  aaatcttag  1860
gttcaaaac  aaatgaaac  aaaaaaaaa  tgataaaaa  tctcaaaaa  acaaggaat  1920
c  1921



<210> 6763
<211> 593
<212> PRT
<213> Homo sapiens
<308> Q99688
<400> 6763

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
  1               5                  10                  15
Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
             20                  25                  30
Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
         35                  40                  45
Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
     50                  55                  60
Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
 65                  70                  75                  80
Lys Leu Asn Glu Cys Leu Gln Glu Val Tyr Glu Pro Asp Trp Pro Gly 
                 85                  90                  95
Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
             100                105                110
Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
         115                120                125
Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
     130                135                140
Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
 145                150                155                160
Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Pro Val Ser 
                 165                170                175
Leu Leu Glu Lys Ala Ala Pro Gln Trp Cys Gln Gly Lys Leu Gln Ala 
             180                185                190
His Leu Val Ala Gln Thr Asn Leu Leu Arg Asn Gln Ala Glu Glu Glu 
         195                200                205
Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu Gln 
     210                215                220
Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val Asn 
 225                230                235                240
Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu Met 
                 245                250                255
Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Gly Leu Glu Lys 
             260                265                270
Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Ser Asp Asn 
         275                280                285
Ala Pro Ala Lys Gly Asn Lys Ser Pro Ser Pro Pro Asp Gly Ser Pro 
     290                295                300
Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala Gly 
 305                310                315                320
Gly Ala Thr Pro Gly Ala Thr Leu Pro Lys Ser Pro Ser Gln Leu Arg 
                 325                330                335
Lys Gly Pro Pro Val Pro Pro Pro Pro Lys His Thr Pro Ser Lys Glu 
             340                345                350
Val Lys Gln Glu Gln Ile Leu Ser Leu Phe Glu Asp Thr Phe Val Pro 
         355                360                365
Glu Ile Ser Val Thr Thr Pro Ser Gln Phe Glu Ala Pro Gly Pro Phe 
     370                375                380
Ser Glu Gln Ala Ser Leu Leu Asp Leu Asp Phe Asp Pro Leu Pro Pro 
 385                390                395                400
Val Thr Ser Pro Val Lys Ala Pro Thr Pro Ser Gly Gln Ser Ile Pro 
                 405                410                415
Trp Asp Leu Trp Glu Pro Thr Glu Ser Pro Ala Gly Ser Leu Pro Ser 
             420                425                430
Gly Glu Pro Ser Ala Ala Glu Gly Thr Phe Ala Val Ser Trp Pro Ser 
         435                440                445
Gln Thr Ala Glu Pro Gly Pro Ala Gln Pro Ala Glu Ala Ser Glu Val 
     450                455                460
Ala Gly Gly Thr Gln Pro Ala Ala Gly Ala Gln Glu Pro Gly Glu Thr 
 465                470                475                480
Ala Ala Ser Glu Ala Ala Ser Ser Ser Leu Pro Ala Val Val Val Glu 
                 485                490                495
Thr Phe Pro Ala Thr Val Asn Gly Thr Val Glu Gly Gly Ser Gly Ala 
             500                505                510
Gly Arg Leu Asp Leu Pro Pro Gly Phe Met Phe Lys Val Gln Ala Gln 
         515                520                525
His Asp Tyr Thr Ala Thr Asp Thr Asp Glu Leu Gln Leu Lys Ala Gly 
     530                535                540
Asp Val Val Leu Val Ile Pro Phe Gln Asn Pro Glu Glu Gln Asp Glu 
 545                550                555                560
Gly Trp Leu Met Gly Val Lys Glu Ser Asp Trp Asn Gln His Lys Glu 
                 565                570                575
Leu Glu Lys Cys Arg Gly Val Phe Pro Glu Asn Phe Thr Glu Arg Val 
             580                585                590
Pro 
         595



<210> 6764
<211> 583
<212> DNA
<213> Rattus norvegicus
<308> AI102031
<400> 6764

ttttttttt  tgggtttgt  cggtttttc  tttttgttt  tttcgctgc  ttttgaaca  60
tagggctta  tttcaaaca  cacacggtt  gtctgcaga  cggaccagg  tgggccaca  120
tgcaggccc  gcccagggc  gctgccaga  gaggaccca  gccctgtcc  gtggcgcgg  180
caagcgtca  gcaagtgcg  cggtggctc  gcacccccg  cccgccctg  acatgcggg  240
atcgggaac  caactagga  ggggacaca  cagcttcgg  aatactgga  aagtccact  300
aactgggtc  gacggcttt  tggaaaacc  cctcatctt  gggggtaca  ctcttggct  360
aggtttccg  tccccaatt  cccgacact  ttcaagagt  tcaaaacaa  acaaaaaac  420
gaaaagaag  ggaagaaaa  caaaaaaaa  aaaagcaca  atcttttgg  aaaaggttc  480
tcacacacc  gaaggctgc  gaggctctc  cgtcactgc  cccgctctg  gaaattctc  540
gggaagacg  cgcggaatt  ctccagttc  ttgggctga  tcc  583



<210> 6765
<211> 588
<212> PRT
<213> Rattus norvegicus
<308> O08839
<400> 6765

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
  1               5                  10                  15
Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
             20                  25                  30
Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
         35                  40                  45
Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
     50                  55                  60
Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
 65                  70                  75                  80
Lys Leu Ser Glu Cys Leu Gln Glu Val Tyr Glu Pro Glu Trp Pro Gly 
                 85                  90                  95
Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
             100                105                110
Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
         115                120                125
Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
     130                135                140
Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
 145                150                155                160
Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Pro Val Ser 
                 165                170                175
Leu Leu Glu Lys Ala Ala Pro Gln Trp Cys Gln Gly Lys Leu Gln Ala 
             180                185                190
His Leu Val Ala Gln Thr Asn Leu Leu Arg Asn Gln Ala Glu Glu Glu 
         195                200                205
Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu Gln 
     210                215                220
Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val Asn 
 225                230                235                240
Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu Met 
                 245                250                255
Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Ser Leu Glu Lys 
             260                265                270
Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Ser Asp Ser 
         275                280                285
Ala Pro Glu Lys Gly Asn Lys Ser Pro Ser Pro Pro Pro Asp Gly Ser 
     290                295                300
Pro Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala 
 305                310                315                320
Ser Gly Ala Ser Pro Gly Ala Thr Ile Pro Lys Ser Pro Ser Gln Leu 
                 325                330                335
Arg Lys Gly Pro Pro Val Pro Pro Pro Pro Lys His Thr Pro Ser Lys 
             340                345                350
Glu Met Lys Gln Glu Gln Ile Leu Ser Leu Phe Asp Asp Ala Phe Val 
         355                360                365
Pro Glu Ile Ser Val Thr Thr Pro Ser Gln Phe Glu Ala Pro Gly Pro 
     370                375                380
Phe Ser Glu Gln Ala Ser Leu Leu Asp Leu Asp Phe Glu Pro Leu Pro 
 385                390                395                400
Pro Val Ala Ser Pro Val Lys Ala Pro Thr Pro Ser Gly Gln Ser Ile 
                 405                410                415
Pro Trp Asp Leu Trp Glu Pro Thr Glu Ser Gln Ala Gly Val Leu Pro 
             420                425                430
Ser Gly Glu Pro Ser Ser Ala Glu Gly Ser Phe Ala Val Ala Trp Pro 
         435                440                445
Ser Gln Thr Ala Glu Pro Gly Pro Ala Gln Pro Ala Glu Ala Ser Glu 
     450                455                460
Val Val Gly Gly Thr Gln Glu Pro Gly Glu Thr Ala Ala Ser Glu Ala 
 465                470                475                480
Thr Ser Ser Ser Leu Pro Ala Val Val Val Glu Thr Phe Ser Ala Thr 
                 485                490                495
Val Asn Gly Ala Val Glu Gly Ser Thr Thr Thr Gly Arg Leu Asp Leu 
             500                505                510
Pro Pro Gly Phe Met Phe Lys Val Gln Ala Gln His Asp Tyr Thr Ala 
         515                520                525
Thr Asp Thr Asp Glu Leu Gln Leu Lys Ala Gly Asp Val Val Leu Val 
     530                535                540
Ile Pro Phe Gln Asn Pro Glu Glu Gln Asp Glu Gly Trp Leu Met Gly 
 545                550                555                560
Val Lys Glu Ser Asp Trp Asn Gln His Lys Glu Leu Glu Lys Cys Arg 
                 565                570                575
Gly Val Phe Pro Glu Asn Phe Thr Glu Arg Val Gln 
             580                585



<210> 6766
<211> 1921
<212> DNA
<213> Homo sapiens
<308> U68485
<400> 6766

ccccgcgcg  gagcggccc  tgccaccgg  cgaggcctg  gccgcgatg  cagagatgg  60
cagtaaagg  gtgacggcg  gaaagatcg  cagcaacgt  cagaagaag  tcacccgcg  120
gcaggagaa  gttctccag  agctgggga  ggcagatga  accaaggat  agcagtttg  180
gcagtgcgt  cagaatttc  acaagcagc  gacggaggg  acccggctg  agaaggatc  240
ccggaccta  ctggcctcc  tcaaagcca  gcacgaggc  tccaagaag  tgaatgagt  300
tctgcagga  gtgtatgag  ccgattggc  cggcaggga  gaggcaaac  agatcgcag  360
gaacaacga  ctgctgtgg  tggattacc  ccagaagct  gtggaccag  cgctgctga  420
catggacac  tacctgggc  agttccccg  catcaagtc  cgcattgcc  agcgggggc  480
caagctggt  gactacgac  gtgcccggc  ccactacga  tcccttcaa  ctgccaaaa  540
gaaggatga  gccaaaatt  ccaaggccg  ggaggagct  atcaaagcc  agaaggtgt  600
tgaggagat  aatgtggat  tgcaggagg  gctgccgtc  ctgtggaac  gccgcgtag  660
tttctacgt  aacacgttc  agagcatcg  gggcctgga  gaaaacttc  acaaggaga  720
gagcaagct  aaccagaac  tcaatgatg  gctggtcgg  ctggagaag  aacacggga  780
caacacctt  acggtcaag  cccagccca  aaagaaaag  aaactgttt  cgcggctgc  840
cagaaagaa  aacagtgac  acgcgcctg  aaaagggaa  aagagccct  cgcctccag  900
tggctcccc  gccgccacc  ccgagatca  agtcaacca  gagccagag  cggccggcg  960
ggccacgcc  ggggccacc  tccccaagt  cccatctca  ccagcagag  cctcggagg  1020
ggcgggtgg  acccaacct  cggctggag  ccaggagcc  ggggagacg  cggcaagtg  1080
agcagcctc  agctctctt  ctgctgtcg  ggtggagac  ttcccagca  ctgtgaatg  1140
caccgtgga  ggcggcagt  gggccgggc  cttggacct  cccccaggt  tcatgttca  1200
ggtacaggc  cagcacgac  acacggcca  tgacacaga  gagctgcag  tcaaggctg  1260
tgatgtggt  ctggtgatc  ccttccaga  ccctgaaga  caggatgaa  gctggctca  1320
gggcgtgaa  gagagcgac  ggaaccagc  caaggagct  gagaagtgc  gtggcgtct  1380
ccccgagaa  ttcactgag  gggtcccat  acggcgggg  ccaggcagc  tccgggcgt  1440
tgaagaaca  ctcctcccg  aaaatgtgt  gttcttttt  ttgttttgt  ttcgttttt  1500
atcttttga  gagcaaagg  aaatcaaga  gagaccccc  ggcagaggg  cgttctccc  1560
aagtttagg  cgttttcca  agagccgcg  cccggcaag  ccggcggaa  tcaccagtg  1620
tcctgaagc  gctgtgtcc  ctagttgag  ttctggcgc  cctgcctgt  cccgcatgt  1680
tgcctggcc  cagggcggg  ctgggggct  ccgagccac  atacttaac  gaagcttcg  1740
ccgcaccac  cggggaagg  tcctctttt  ctggcagct  ctgtgggtg  ggcccagac  1800
ccagcctag  ctgctctgc  ccgcagacg  tctgtgtgc  gtttgaaaa  aaatcttag  1860
gttcaaaac  aaatgaaac  aaaaaaaaa  tgataaaaa  tctcaaaaa  acaaggaat  1920
c  1921



<210> 6767
<211> 593
<212> PRT
<213> Homo sapiens
<308> Q99688
<400> 6767

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
  1               5                  10                  15
Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
             20                  25                  30
Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
         35                  40                  45
Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
     50                  55                  60
Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
 65                  70                  75                  80
Lys Leu Asn Glu Cys Leu Gln Glu Val Tyr Glu Pro Asp Trp Pro Gly 
                 85                  90                  95
Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
             100                105                110
Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
         115                120                125
Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
     130                135                140
Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
 145                150                155                160
Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Pro Val Ser 
                 165                170                175
Leu Leu Glu Lys Ala Ala Pro Gln Trp Cys Gln Gly Lys Leu Gln Ala 
             180                185                190
His Leu Val Ala Gln Thr Asn Leu Leu Arg Asn Gln Ala Glu Glu Glu 
         195                200                205
Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu Gln 
     210                215                220
Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val Asn 
 225                230                235                240
Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu Met 
                 245                250                255
Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Gly Leu Glu Lys 
             260                265                270
Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Ser Asp Asn 
         275                280                285
Ala Pro Ala Lys Gly Asn Lys Ser Pro Ser Pro Pro Asp Gly Ser Pro 
     290                295                300
Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala Gly 
 305                310                315                320
Gly Ala Thr Pro Gly Ala Thr Leu Pro Lys Ser Pro Ser Gln Leu Arg 
                 325                330                335
Lys Gly Pro Pro Val Pro Pro Pro Pro Lys His Thr Pro Ser Lys Glu 
             340                345                350
Val Lys Gln Glu Gln Ile Leu Ser Leu Phe Glu Asp Thr Phe Val Pro 
         355                360                365
Glu Ile Ser Val Thr Thr Pro Ser Gln Phe Glu Ala Pro Gly Pro Phe 
     370                375                380
Ser Glu Gln Ala Ser Leu Leu Asp Leu Asp Phe Asp Pro Leu Pro Pro 
 385                390                395                400
Val Thr Ser Pro Val Lys Ala Pro Thr Pro Ser Gly Gln Ser Ile Pro 
                 405                410                415
Trp Asp Leu Trp Glu Pro Thr Glu Ser Pro Ala Gly Ser Leu Pro Ser 
             420                425                430
Gly Glu Pro Ser Ala Ala Glu Gly Thr Phe Ala Val Ser Trp Pro Ser 
         435                440                445
Gln Thr Ala Glu Pro Gly Pro Ala Gln Pro Ala Glu Ala Ser Glu Val 
     450                455                460
Ala Gly Gly Thr Gln Pro Ala Ala Gly Ala Gln Glu Pro Gly Glu Thr 
 465                470                475                480
Ala Ala Ser Glu Ala Ala Ser Ser Ser Leu Pro Ala Val Val Val Glu 
                 485                490                495
Thr Phe Pro Ala Thr Val Asn Gly Thr Val Glu Gly Gly Ser Gly Ala 
             500                505                510
Gly Arg Leu Asp Leu Pro Pro Gly Phe Met Phe Lys Val Gln Ala Gln 
         515                520                525
His Asp Tyr Thr Ala Thr Asp Thr Asp Glu Leu Gln Leu Lys Ala Gly 
     530                535                540
Asp Val Val Leu Val Ile Pro Phe Gln Asn Pro Glu Glu Gln Asp Glu 
 545                550                555                560
Gly Trp Leu Met Gly Val Lys Glu Ser Asp Trp Asn Gln His Lys Glu 
                 565                570                575
Leu Glu Lys Cys Arg Gly Val Phe Pro Glu Asn Phe Thr Glu Arg Val 
             580                585                590
Pro 
         595



<210> 6768
<211> 549
<212> DNA
<213> Rattus norvegicus
<308> AI102044
<400> 6768

attgtgggg  tagtaccta  gattcgata  ttgacaatg  ttatccggg  tgtcataca  60
ttgggctag  aaaattggt  cttgttact  atattaaca  tttttcatc  atgggtcta  120
aaattaccc  aatttgtaa  ataggaatt  attgaggtt  ggggaatta  tgtgtgtaa  180
tatgtatgt  gagcttgaa  cctttcttt  ttgatggct  cttttaacc  tacaatggt  240
aaggggttg  agttgttta  tcactattt  agggttttt  cttttccta  aaagctggc  300
ctcttttgg  tatatttta  gtttacatt  tgatttgtt  ttctgatgg  aagcttaaa  360
ttgaactga  attcttttt  gggcaacca  ctttcacca  gctcgatag  cttttcacc  420
ttacctaaa  atcttccca  tattttgct  cataaacgg  ttgattcat  aaattgttt  480
taggtagct  gtttggttt  ggggttctt  gcttaaatt  tttttgtta  ggattttct  540
gttaattca  549



<210> 6769
<211> 2201
<212> DNA
<213> Homo sapiens
<308> L22009
<400> 6769

ttttttttt  cgtcttagc  acgcagaag  cgcgtgtct  gtttgtttc  acgccggac  60
gcgtaagag  cgatgatgt  gggcacgga  ggtggagag  gattcgtgg  gaaggtccg  120
ggcttgccc  ggtcttgct  ggccgatga  gtgcagagg  ttttttctg  ctgcaaaat  180
caaaatggg  ctcaaggta  tcgtttcat  tacaccaga  aaggcagac  aagtggcga  240
gcttttgtt  aacttgaat  agaagatga  gtcaaattg  ccctgaaaa  agacagaga  300
actatggga  acagatatg  tgaagtatt  aagtcaaac  acgttgaaa  ggattgggt  360
ttgaagcat  ctggtccaa  tagtcctga  acggccaat  atggctttg  acggcttag  420
ggacttccc  ttggatgta  caaggaaga  attgttcag  tcttctcag  gttggaaat  480
gtgccaaat  ggataacat  gccggtgga  ttccagggg  ggagtacgg  ggaggcctt  540
gtgcagttt  cttcacagg  aatagctga  aaggctcta  agaaacaca  ggaaagaat  600
gggcacagg  atattgaaa  ctttaagag  agtagagct  aagttagaa  tcattatga  660
ccaccacga  agcttatgg  catgcagcg  ccaggtcct  atgacagac  tggggctgg  720
agagggtat  acagcattg  cagaggagc  ggctttgag  ggatgaggc  tggtgctta  780
ggtggaggc  atggaggct  tgatgatta  aatggctat  atgatggct  tggatttgg  840
tcagataga  ttggaagag  cctcaatta  tgtttttca  gaatgtctg  tcacagata  900
ggggatggt  gctctactt  ccagagcac  acaggacac  gtgtacaca  gcggggatt  960
ccttacaga  ctactgaga  tgacattta  aattttttt  caccgctca  ccctgtgag  1020
gtacacatt  aaattggtc  tgatggcag  gtaactggt  aagcagatg  cgagttcgc  1080
actcatgaa  atgctgtgg  agctatgtc  aaagacaaa  caaatatgc  acacagata  1140
gtagaactc  tcttgaatt  tacagcagg  gcaagcggt  gtgcttacg  acacagata  1200
gtagaactc  tcttgaatt  tacagcagg  gcaagcggt  gtgcttatg  tagccaaat  1260
atgggaggc  tgggcttgt  aaaccagtc  agctacggg  gcccagcca  ccagcagct  1320
agtgggggt  acggaggcg  ctacggtgg  cagagcagc  tgagtggat  cgaccaagt  1380
ttacaggaa  actccagtg  ttttcaatc  aacattgca  aggtaacca  ggagcagtg  1440
acagcagct  ctacagtag  ggaagccgt  catctatgg  cgtgaacgg  atgggaggg  1500
tgtctagca  gtccagtat  agtggtgga  ggggaatgt  attgatcga  cctgatcac  1560
gactcttgg  caacctttt  ttttttttt  ttttcttta  gaaaacttc  gtttaacag  1620
ttctgcaat  caagcttgt  atttatgct  actctaagt  gaaatcagg  ttgttatga  1680
gacttaagg  ccagtattt  tgaatacaa  actcatcta  gatgtaaca  tgaagctga  1740
taaactata  ctgttaaac  taagttcca  cttttctca  gttagttat  ggatgtact  1800
aagcagtaa  cgtatttag  taaaagcag  tgaattatg  taaatgttg  cctttgcca  1860
gttaaattg  acactgttt  ggatgcatg  tgaaagaca  gcttttatt  tttttgtaa  1920
acaatatag  agctgtgtc  actattaaa  gtgaaacat  ttggcatgt  tgttaattc  1980
agtttcatt  aataacctg  aaggcacgt  agtttaagc  ttttttttt  ttaagttaa  2040
gggaaaaat  tgagacgca  taccaatac  taggatttt  gtcttggtg  ttgtatgaa  2100
ttctgaggc  ttgatttaa  tctttcatt  tattgtgat  tccttttag  tatattgcg  2160
taagtgaaa  ttgtcaaat  aatcctcct  ttaaaaact  c  2201



<210> 6770
<211> 449
<212> PRT
<213> Homo sapiens
<308> P31943
<400> 6770

Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
  1               5                  10                  15
Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
             20                  25                  30
Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
         35                  40                  45
Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
     50                  55                  60
Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
 65                  70                  75                  80
Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                 85                  90                  95
Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
             100                105                110
Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
         115                120                125
Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
     130                135                140
Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
 145                150                155                160
Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                 165                170                175
Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
             180                185                190
Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
         195                200                205
Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
     210                215                220
Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
 225                230                235                240
Gly Gly Tyr Asp Asp Tyr Asn Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                 245                250                255
Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
             260                265                270
Asp His Arg Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr Thr Gly 
         275                280                285
His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
     290                295                300
Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
 305                310                315                320
Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                 325                330                335
Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Ala Asn Met 
             340                345                350
Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Ala Ser 
         355                360                365
Gly Gly Ala Tyr Glu His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr 
     370                375                380
Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
 385                390                395                400
Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                 405                410                415
Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
             420                425                430
Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser Asn Ile 
         435                440                445
Ala 
     450



<210> 6771
<211> 602
<212> DNA
<213> Rattus norvegicus
<308> AI102103
<400> 6771

gatggctaa  taaggactt  atttcaaac  aaaattaaa  attaaaaaa  aaaaaaaat  60
agagctatt  ccctgggtg  gaggaaagg  tcagggtga  aaatttccc  atggctaag  120
caataccct  aatatatta  agggatcgt  tcagttccc  tccttaccc  catgatggg  180
aacctaagc  agtgcagga  ccacctgtc  ggaatgtgg  ctaggggtc  gcccccaaa  240
ggggacaga  ttgggcagc  gcatggcca  acataggat  aagtcctaa  taccaagaa  300
ccactcctc  catcttgct  ggacccagg  aaagtaaaa  atggttttg  agaaaacct  360
tgagatccc  gaggggaag  aggttccag  cctcctcat  ttcatcatc  ctgttctct  420
gagggcagt  agtcctggg  tctgtcagg  ggcaatact  acacagcaa  aggtgggga  480
gccccagca  gtctggacc  catggttgg  tctcctacc  tttggccag  tctcatggt  540
accacatga  cctttgtgt  ttttgcctt  catttccct  gggtaggtg  ttaggtagg  600
gg  602



<210> 6772
<211> 816
<212> PRT
<213> Rattus norvegicus
<308> BAA18969
<400> 6772

Met Gly Asp Met Val Val Glu Pro Ala Thr Leu Lys Pro Thr Ser Glu 
  1               5                  10                  15
Pro Thr Pro Ser Pro Ser Gly Asn Asn Gly Gly Ser Leu Leu Ser Val 
             20                  25                  30
Ile Thr Glu Gly Val Gly Glu Leu Ser Val Ile Asp Pro Glu Val Ala 
         35                  40                  45
Gln Lys Ala Cys Gln Glu Val Leu Glu Lys Val Lys Leu Leu His Gly 
     50                  55                  60
Gly Val Ala Ile Ser Ser Lys Gly Ser Pro Leu Glu Leu Val Asn Gly 
 65                  70                  75                  80
Asp Gly Val Asp Asn Glu Ile Arg Cys Leu Asp Asp Pro Pro Thr Glu 
                 85                  90                  95
Ile Arg Glu Glu Glu Asp Glu Met Glu Pro Gly Val Val Ser Gly Thr 
             100                105                110
Ala Lys Gly Thr Arg Arg Arg Arg Gln Asn Asn Ser Ala Lys Gln Ser 
         115                120                125
Trp Leu Leu Arg Leu Phe Glu Ser Lys Leu Phe Asp Ile Ser Met Ala 
     130                135                140
Ile Ser Tyr Leu Tyr Asn Ser Lys Glu Pro Gly Val Gln Ala Tyr Ile 
 145                150                155                160
Gly Asn Arg Leu Phe Cys Phe Arg Asn Glu Asp Val Asp Phe Tyr Leu 
                 165                170                175
Pro Gln Leu Leu Asn Met Tyr Ile His Met Asp Glu Asp Val Gly Asp 
             180                185                190
Ala Ile Lys Pro Tyr Ile Val His Arg Cys Arg Gln Ser Ile Asn Phe 
         195                200                205
Ser Leu Gln Cys Ala Leu Leu Leu Gly Ala Tyr Ser Ser Asp Met His 
     210                215                220
Ile Ser Thr Gln Arg His Ser Arg Gly Thr Lys Leu Arg Lys Leu Ile 
 225                230                235                240
Leu Ser Asp Glu Leu Lys Pro Ala His Arg Lys Arg Glu Leu Pro Thr 
                 245                250                255
Leu Ser Pro Ala Pro Asp Thr Gly Leu Ser Pro Ser Lys Arg Thr His 
             260                265                270
Gln Arg Ser Lys Ser Asp Ala Thr Ala Ser Ile Ser Leu Ser Ser Asn 
         275                280                285
Leu Lys Arg Thr Ala Ser Asn Pro Lys Val Glu Asn Glu Asp Glu Glu 
     290                295                300
Leu Ser Ser Ser Thr Glu Ser Ile Asp Asn Ser Phe Ser Ser Pro Val 
 305                310                315                320
Arg Leu Ala Pro Glu Arg Glu Phe Ile Lys Ser Leu Met Ala Ile Gly 
                 325                330                335
Lys Arg Leu Ala Thr Leu Pro Thr Lys Glu Gln Lys Thr Gln Arg Leu 
             340                345                350
Ile Ser Glu Leu Ser Leu Leu Asn His Lys Leu Pro Ala Arg Val Trp 
         355                360                365
Leu Pro Thr Ala Gly Phe Asp His His Val Val Arg Val Pro His Thr 
     370                375                380
Gln Ala Val Val Leu Asn Ser Lys Asp Lys Ala Pro Tyr Leu Ile Tyr 
 385                390                395                400
Val Glu Val Leu Glu Cys Glu Asn Phe Asp Thr Thr Asn Val Pro Ala 
                 405                410                415
Arg Ile Pro Glu Asn Arg Ile Arg Ser Thr Arg Ser Val Glu Asn Leu 
             420                425                430
Pro Glu Cys Gly Ile Thr His Glu Gln Arg Ala Gly Ser Phe Ser Thr 
         435                440                445
Val Pro Asn Tyr Asp Asn Asp Asp Glu Ala Trp Ser Val Asp Asp Ile 
     450                455                460
Gly Glu Leu Gln Val Glu Leu Pro Glu Val His Thr Asn Ser Cys Asp 
 465                470                475                480
Asn Ile Ser Gln Phe Ser Val Asp Ser Ile Thr Ser Gln Glu Ser Lys 
                 485                490                495
Glu Pro Val Phe Ile Ala Ala Gly Asp Ile Arg Arg Arg Leu Ser Glu 
             500                505                510
Gln Leu Ala His Thr Pro Thr Ala Phe Lys Arg Asp Pro Glu Asp Pro 
         515                520                525
Ser Ala Val Ala Leu Lys Glu Pro Trp Gln Glu Lys Val Arg Arg Ile 
     530                535                540
Arg Glu Gly Ser Pro Tyr Gly His Leu Pro Asn Trp Arg Leu Leu Ser 
 545                550                555                560
Val Ile Val Lys Cys Gly Asp Asp Leu Arg Gln Glu Leu Leu Ala Phe 
                 565                570                575
Gln Val Leu Lys Gln Leu Gln Ser Ile Trp Glu Gln Glu Arg Val Pro 
             580                585                590
Leu Trp Ile Lys Pro Tyr Lys Ile Leu Val Ile Ser Ala Asp Ser Gly 
         595                600                605
Met Ile Glu Pro Val Val Asn Ala Val Ser Ile His Gln Val Lys Lys 
     610                615                620
Gln Ser Gln Leu Ser Leu Leu Asp Tyr Phe Leu Gln Glu His Gly Ser 
 625                630                635                640
Tyr Thr Thr Glu Ala Phe Leu Ser Ala Gln Arg Asn Phe Val Gln Ser 
                 645                650                655
Cys Ala Gly Tyr Cys Leu Val Cys Tyr Leu Leu Gln Val Lys Asp Arg 
             660                665                670
His Asn Gly Asn Ile Leu Leu Asp Ala Glu Gly His Ile Ile His Ile 
         675                680                685
Asp Phe Gly Phe Ile Leu Ser Ser Ser Pro Arg Asn Leu Gly Phe Glu 
     690                695                700
Thr Ser Ala Phe Lys Leu Thr Thr Glu Phe Val Asp Val Met Gly Gly 
 705                710                715                720
Leu Asn Gly Asp Met Phe Asn Tyr Tyr Lys Met Leu Met Leu Gln Gly 
                 725                730                735
Leu Ile Ala Ala Arg Lys His Met Asp Lys Val Val Gln Ile Val Glu 
             740                745                750
Ile Met Gln Gln Gly Ser Gln Leu Pro Cys Phe His Gly Ser Ser Thr 
         755                760                765
Ile Arg Asn Leu Lys Glu Arg Phe His Met Ser Met Thr Glu Glu Gln 
     770                775                780
Leu Gln Leu Leu Val Glu Gln Met Val Asp Gly Ser Met Arg Ser Ile 
 785                790                795                800
Thr Thr Lys Leu Tyr Asp Gly Phe Gln Tyr Leu Thr Asn Gly Ile Met 
                 805                810                815



<210> 6773
<211> 334
<212> DNA
<213> Homo sapiens
<308> AI205643
<400> 6773

ttctcagga  tcctttatt  ttgtagtaa  aataatact  acaaacagt  ggggaacta  60
ggagaaaac  agaccatta  aactgttgt  gtcgaatct  cattcaggc  tctcttttt  120
tgtgacttg  acaatgtgg  gttgaagcg  gtgagagaa  atggaagga  aagttaatg  180
tctggcggc  acggtggac  atgtagggc  taatggcat  acccacgtc  tcatccatg  240
ggatgtaca  gttaagcaa  tggggcaga  agaagtcca  gtcctcgtt  cgaaagcag  300
agagccggt  gccaatggt  gcttgtact  cagc  334



<210> 6774
<211> 828
<212> PRT
<213> Homo sapiens
<308> BAA21661
<400> 6774

Met Arg Phe Leu Glu Ala Arg Ser Leu Ala Val Ala Met Gly Asp Thr 
  1               5                  10                  15
Val Val Glu Pro Ala Pro Leu Lys Pro Thr Ser Glu Pro Thr Ser Gly 
             20                  25                  30
Pro Pro Gly Asn Asn Gly Gly Ser Leu Leu Ser Val Ile Thr Glu Gly 
         35                  40                  45
Val Gly Glu Leu Ser Val Ile Asp Pro Glu Val Ala Gln Lys Ala Cys 
     50                  55                  60
Gln Glu Val Leu Glu Lys Val Lys Leu Leu His Gly Gly Val Ala Val 
 65                  70                  75                  80
Ser Ser Arg Gly Thr Pro Leu Glu Leu Val Asn Gly Asp Gly Val Asp 
                 85                  90                  95
Ser Glu Ile Arg Cys Leu Asp Asp Pro Pro Ala Gln Ile Arg Glu Glu 
             100                105                110
Glu Asp Glu Met Gly Ala Ala Val Ala Ser Gly Thr Ala Lys Gly Ala 
         115                120                125
Arg Arg Arg Arg Gln Asn Asn Ser Ala Lys Gln Ser Trp Leu Leu Arg 
     130                135                140
Leu Phe Glu Ser Lys Leu Phe Asp Ile Ser Met Ala Ile Ser Tyr Leu 
 145                150                155                160
Tyr Asn Ser Lys Glu Pro Gly Val Gln Ala Tyr Ile Gly Asn Arg Leu 
                 165                170                175
Phe Cys Phe Arg Asn Glu Asp Val Asp Phe Tyr Leu Pro Gln Leu Leu 
             180                185                190
Asn Met Tyr Ile His Met Asp Glu Asp Val Gly Asp Ala Ile Lys Pro 
         195                200                205
Tyr Ile Val His Arg Cys Arg Gln Ser Ile Asn Phe Ser Leu Gln Cys 
     210                215                220
Ala Leu Leu Leu Gly Ala Tyr Ser Ser Asp Met His Ile Ser Thr Gln 
 225                230                235                240
Arg His Ser Arg Gly Thr Lys Leu Arg Lys Leu Ile Leu Ser Asp Glu 
                 245                250                255
Leu Lys Pro Ala His Arg Lys Arg Glu Leu Pro Ser Leu Ser Pro Ala 
             260                265                270
Pro Asp Thr Gly Leu Ser Pro Ser Lys Arg Thr His Gln Arg Ser Lys 
         275                280                285
Ser Asp Ala Thr Ala Ser Ile Ser Leu Ser Ser Asn Leu Lys Arg Thr 
     290                295                300
Ala Ser Asn Pro Lys Val Glu Asn Glu Asp Glu Glu Leu Ser Ser Ser 
 305                310                315                320
Thr Glu Ser Ile Asp Asn Ser Phe Ser Ser Pro Val Arg Leu Ala Pro 
                 325                330                335
Glu Arg Glu Phe Ile Lys Ser Leu Met Ala Ile Gly Lys Arg Leu Ala 
             340                345                350
Thr Leu Pro Thr Lys Glu Gln Lys Thr Gln Arg Leu Ile Ser Glu Leu 
         355                360                365
Ser Leu Leu Asn His Lys Leu Pro Ala Arg Val Trp Leu Pro Thr Ala 
     370                375                380
Gly Phe Asp His His Val Val Arg Val Pro His Thr Gln Ala Val Val 
 385                390                395                400
Leu Asn Ser Lys Asp Lys Ala Pro Tyr Leu Ile Tyr Val Glu Val Leu 
                 405                410                415
Glu Cys Glu Asn Phe Asp Thr Thr Ser Val Pro Ala Arg Ile Pro Glu 
             420                425                430
Asn Arg Ile Arg Ser Thr Arg Ser Val Glu Asn Leu Pro Glu Cys Gly 
         435                440                445
Ile Thr His Glu Gln Arg Ala Gly Ser Phe Ser Thr Val Pro Asn Tyr 
     450                455                460
Asp Asn Asp Asp Glu Ala Trp Ser Val Asp Asp Ile Gly Glu Leu Gln 
 465                470                475                480
Val Glu Leu Pro Glu Val His Thr Asn Ser Cys Asp Asn Ile Ser Gln 
                 485                490                495
Phe Ser Val Asp Ser Ile Thr Ser Gln Glu Ser Lys Glu Pro Val Phe 
             500                505                510
Ile Ala Ala Gly Asp Ile Arg Arg Arg Leu Ser Glu Gln Leu Ala His 
         515                520                525
Thr Pro Thr Ala Phe Lys Arg Asp Pro Glu Asp Pro Ser Ala Val Ala 
     530                535                540
Leu Lys Glu Pro Trp Gln Glu Lys Val Arg Arg Ile Arg Glu Gly Ser 
 545                550                555                560
Pro Tyr Gly His Leu Pro Asn Trp Arg Leu Leu Ser Val Ile Val Lys 
                 565                570                575
Cys Gly Asp Asp Leu Arg Gln Glu Leu Leu Ala Phe Gln Val Leu Lys 
             580                585                590
Gln Leu Gln Ser Ile Trp Glu Gln Glu Arg Val Pro Leu Trp Ile Lys 
         595                600                605
Pro Tyr Lys Ile Leu Val Ile Ser Ala Asp Ser Gly Met Ile Glu Pro 
     610                615                620
Val Val Asn Ala Val Ser Ile His Gln Val Lys Lys Gln Ser Gln Leu 
 625                630                635                640
Ser Leu Leu Asp Tyr Phe Leu Gln Glu His Gly Ser Tyr Thr Thr Glu 
                 645                650                655
Ala Phe Leu Ser Ala Gln Arg Asn Phe Val Gln Ser Cys Ala Gly Tyr 
             660                665                670
Cys Leu Val Cys Tyr Leu Leu Gln Val Lys Asp Arg His Asn Gly Asn 
         675                680                685
Ile Leu Leu Asp Ala Glu Gly His Ile Ile His Ile Asp Phe Gly Phe 
     690                695                700
Ile Leu Ser Ser Ser Pro Arg Asn Leu Gly Phe Glu Thr Ser Ala Phe 
 705                710                715                720
Lys Leu Thr Thr Glu Phe Val Asp Val Met Gly Gly Leu Asp Gly Asp 
                 725                730                735
Met Phe Asn Tyr Tyr Lys Met Leu Met Leu Gln Gly Leu Ile Ala Ala 
             740                745                750
Arg Lys His Met Asp Lys Val Val Gln Ile Val Glu Ile Met Gln Gln 
         755                760                765
Gly Ser Gln Leu Pro Cys Phe His Gly Ser Ser Thr Ile Arg Asn Leu 
     770                775                780
Lys Glu Arg Phe His Met Ser Met Thr Glu Glu Gln Leu Gln Leu Leu 
 785                790                795                800
Val Glu Gln Met Val Asp Gly Ser Met Arg Ser Ile Thr Thr Lys Leu 
                 805                810                815
Tyr Asp Gly Phe Gln Tyr Leu Thr Asn Gly Ile Met 
             820                825



<210> 6775
<211> 602
<212> DNA
<213> Rattus norvegicus
<308> AI102103
<400> 6775

gatggctaa  taaggactt  atttcaaac  aaaattaaa  attaaaaaa  aaaaaaaat  60
agagctatt  ccctgggtg  gaggaaagg  tcagggtga  aaatttccc  atggctaag  120
caataccct  aatatatta  agggatcgt  tcagttccc  tccttaccc  catgatggg  180
aacctaagc  agtgcagga  ccacctgtc  ggaatgtgg  ctaggggtc  gcccccaaa  240
ggggacaga  ttgggcagc  gcatggcca  acataggat  aagtcctaa  taccaagaa  300
ccactcctc  catcttgct  ggacccagg  aaagtaaaa  atggttttg  agaaaacct  360
tgagatccc  gaggggaag  aggttccag  cctcctcat  ttcatcatc  ctgttctct  420
gagggcagt  agtcctggg  tctgtcagg  ggcaatact  acacagcaa  aggtgggga  480
gccccagca  gtctggacc  catggttgg  tctcctacc  tttggccag  tctcatggt  540
accacatga  cctttgtgt  ttttgcctt  catttccct  gggtaggtg  ttaggtagg  600
gg  602



<210> 6776
<211> 816
<212> PRT
<213> Rattus norvegicus
<308> BAA18969
<400> 6776

Met Gly Asp Met Val Val Glu Pro Ala Thr Leu Lys Pro Thr Ser Glu 
  1               5                  10                  15
Pro Thr Pro Ser Pro Ser Gly Asn Asn Gly Gly Ser Leu Leu Ser Val 
             20                  25                  30
Ile Thr Glu Gly Val Gly Glu Leu Ser Val Ile Asp Pro Glu Val Ala 
         35                  40                  45
Gln Lys Ala Cys Gln Glu Val Leu Glu Lys Val Lys Leu Leu His Gly 
     50                  55                  60
Gly Val Ala Ile Ser Ser Lys Gly Ser Pro Leu Glu Leu Val Asn Gly 
 65                  70                  75                  80
Asp Gly Val Asp Asn Glu Ile Arg Cys Leu Asp Asp Pro Pro Thr Glu 
                 85                  90                  95
Ile Arg Glu Glu Glu Asp Glu Met Glu Pro Gly Val Val Ser Gly Thr 
             100                105                110
Ala Lys Gly Thr Arg Arg Arg Arg Gln Asn Asn Ser Ala Lys Gln Ser 
         115                120                125
Trp Leu Leu Arg Leu Phe Glu Ser Lys Leu Phe Asp Ile Ser Met Ala 
     130                135                140
Ile Ser Tyr Leu Tyr Asn Ser Lys Glu Pro Gly Val Gln Ala Tyr Ile 
 145                150                155                160
Gly Asn Arg Leu Phe Cys Phe Arg Asn Glu Asp Val Asp Phe Tyr Leu 
                 165                170                175
Pro Gln Leu Leu Asn Met Tyr Ile His Met Asp Glu Asp Val Gly Asp 
             180                185                190
Ala Ile Lys Pro Tyr Ile Val His Arg Cys Arg Gln Ser Ile Asn Phe 
         195                200                205
Ser Leu Gln Cys Ala Leu Leu Leu Gly Ala Tyr Ser Ser Asp Met His 
     210                215                220
Ile Ser Thr Gln Arg His Ser Arg Gly Thr Lys Leu Arg Lys Leu Ile 
 225                230                235                240
Leu Ser Asp Glu Leu Lys Pro Ala His Arg Lys Arg Glu Leu Pro Thr 
                 245                250                255
Leu Ser Pro Ala Pro Asp Thr Gly Leu Ser Pro Ser Lys Arg Thr His 
             260                265                270
Gln Arg Ser Lys Ser Asp Ala Thr Ala Ser Ile Ser Leu Ser Ser Asn 
         275                280                285
Leu Lys Arg Thr Ala Ser Asn Pro Lys Val Glu Asn Glu Asp Glu Glu 
     290                295                300
Leu Ser Ser Ser Thr Glu Ser Ile Asp Asn Ser Phe Ser Ser Pro Val 
 305                310                315                320
Arg Leu Ala Pro Glu Arg Glu Phe Ile Lys Ser Leu Met Ala Ile Gly 
                 325                330                335
Lys Arg Leu Ala Thr Leu Pro Thr Lys Glu Gln Lys Thr Gln Arg Leu 
             340                345                350
Ile Ser Glu Leu Ser Leu Leu Asn His Lys Leu Pro Ala Arg Val Trp 
         355                360                365
Leu Pro Thr Ala Gly Phe Asp His His Val Val Arg Val Pro His Thr 
     370                375                380
Gln Ala Val Val Leu Asn Ser Lys Asp Lys Ala Pro Tyr Leu Ile Tyr 
 385                390                395                400
Val Glu Val Leu Glu Cys Glu Asn Phe Asp Thr Thr Asn Val Pro Ala 
                 405                410                415
Arg Ile Pro Glu Asn Arg Ile Arg Ser Thr Arg Ser Val Glu Asn Leu 
             420                425                430
Pro Glu Cys Gly Ile Thr His Glu Gln Arg Ala Gly Ser Phe Ser Thr 
         435                440                445
Val Pro Asn Tyr Asp Asn Asp Asp Glu Ala Trp Ser Val Asp Asp Ile 
     450                455                460
Gly Glu Leu Gln Val Glu Leu Pro Glu Val His Thr Asn Ser Cys Asp 
 465                470                475                480
Asn Ile Ser Gln Phe Ser Val Asp Ser Ile Thr Ser Gln Glu Ser Lys 
                 485                490                495
Glu Pro Val Phe Ile Ala Ala Gly Asp Ile Arg Arg Arg Leu Ser Glu 
             500                505                510
Gln Leu Ala His Thr Pro Thr Ala Phe Lys Arg Asp Pro Glu Asp Pro 
         515                520                525
Ser Ala Val Ala Leu Lys Glu Pro Trp Gln Glu Lys Val Arg Arg Ile 
     530                535                540
Arg Glu Gly Ser Pro Tyr Gly His Leu Pro Asn Trp Arg Leu Leu Ser 
 545                550                555                560
Val Ile Val Lys Cys Gly Asp Asp Leu Arg Gln Glu Leu Leu Ala Phe 
                 565                570                575
Gln Val Leu Lys Gln Leu Gln Ser Ile Trp Glu Gln Glu Arg Val Pro 
             580                585                590
Leu Trp Ile Lys Pro Tyr Lys Ile Leu Val Ile Ser Ala Asp Ser Gly 
         595                600                605
Met Ile Glu Pro Val Val Asn Ala Val Ser Ile His Gln Val Lys Lys 
     610                615                620
Gln Ser Gln Leu Ser Leu Leu Asp Tyr Phe Leu Gln Glu His Gly Ser 
 625                630                635                640
Tyr Thr Thr Glu Ala Phe Leu Ser Ala Gln Arg Asn Phe Val Gln Ser 
                 645                650                655
Cys Ala Gly Tyr Cys Leu Val Cys Tyr Leu Leu Gln Val Lys Asp Arg 
             660                665                670
His Asn Gly Asn Ile Leu Leu Asp Ala Glu Gly His Ile Ile His Ile 
         675                680                685
Asp Phe Gly Phe Ile Leu Ser Ser Ser Pro Arg Asn Leu Gly Phe Glu 
     690                695                700
Thr Ser Ala Phe Lys Leu Thr Thr Glu Phe Val Asp Val Met Gly Gly 
 705                710                715                720
Leu Asn Gly Asp Met Phe Asn Tyr Tyr Lys Met Leu Met Leu Gln Gly 
                 725                730                735
Leu Ile Ala Ala Arg Lys His Met Asp Lys Val Val Gln Ile Val Glu 
             740                745                750
Ile Met Gln Gln Gly Ser Gln Leu Pro Cys Phe His Gly Ser Ser Thr 
         755                760                765
Ile Arg Asn Leu Lys Glu Arg Phe His Met Ser Met Thr Glu Glu Gln 
     770                775                780
Leu Gln Leu Leu Val Glu Gln Met Val Asp Gly Ser Met Arg Ser Ile 
 785                790                795                800
Thr Thr Lys Leu Tyr Asp Gly Phe Gln Tyr Leu Thr Asn Gly Ile Met 
                 805                810                815



<210> 6777
<211> 334
<212> DNA
<213> Homo sapiens
<308> AI205643
<400> 6777

ttctcagga  tcctttatt  ttgtagtaa  aataatact  acaaacagt  ggggaacta  60
ggagaaaac  agaccatta  aactgttgt  gtcgaatct  cattcaggc  tctcttttt  120
tgtgacttg  acaatgtgg  gttgaagcg  gtgagagaa  atggaagga  aagttaatg  180
tctggcggc  acggtggac  atgtagggc  taatggcat  acccacgtc  tcatccatg  240
ggatgtaca  gttaagcaa  tggggcaga  agaagtcca  gtcctcgtt  cgaaagcag  300
agagccggt  gccaatggt  gcttgtact  cagc  334



<210> 6778
<211> 828
<212> PRT
<213> Homo sapiens
<308> BAA21661
<400> 6778

Met Arg Phe Leu Glu Ala Arg Ser Leu Ala Val Ala Met Gly Asp Thr 
  1               5                  10                  15
Val Val Glu Pro Ala Pro Leu Lys Pro Thr Ser Glu Pro Thr Ser Gly 
             20                  25                  30
Pro Pro Gly Asn Asn Gly Gly Ser Leu Leu Ser Val Ile Thr Glu Gly 
         35                  40                  45
Val Gly Glu Leu Ser Val Ile Asp Pro Glu Val Ala Gln Lys Ala Cys 
     50                  55                  60
Gln Glu Val Leu Glu Lys Val Lys Leu Leu His Gly Gly Val Ala Val 
 65                  70                  75                  80
Ser Ser Arg Gly Thr Pro Leu Glu Leu Val Asn Gly Asp Gly Val Asp 
                 85                  90                  95
Ser Glu Ile Arg Cys Leu Asp Asp Pro Pro Ala Gln Ile Arg Glu Glu 
             100                105                110
Glu Asp Glu Met Gly Ala Ala Val Ala Ser Gly Thr Ala Lys Gly Ala 
         115                120                125
Arg Arg Arg Arg Gln Asn Asn Ser Ala Lys Gln Ser Trp Leu Leu Arg 
     130                135                140
Leu Phe Glu Ser Lys Leu Phe Asp Ile Ser Met Ala Ile Ser Tyr Leu 
 145                150                155                160
Tyr Asn Ser Lys Glu Pro Gly Val Gln Ala Tyr Ile Gly Asn Arg Leu 
                 165                170                175
Phe Cys Phe Arg Asn Glu Asp Val Asp Phe Tyr Leu Pro Gln Leu Leu 
             180                185                190
Asn Met Tyr Ile His Met Asp Glu Asp Val Gly Asp Ala Ile Lys Pro 
         195                200                205
Tyr Ile Val His Arg Cys Arg Gln Ser Ile Asn Phe Ser Leu Gln Cys 
     210                215                220
Ala Leu Leu Leu Gly Ala Tyr Ser Ser Asp Met His Ile Ser Thr Gln 
 225                230                235                240
Arg His Ser Arg Gly Thr Lys Leu Arg Lys Leu Ile Leu Ser Asp Glu 
                 245                250                255
Leu Lys Pro Ala His Arg Lys Arg Glu Leu Pro Ser Leu Ser Pro Ala 
             260                265                270
Pro Asp Thr Gly Leu Ser Pro Ser Lys Arg Thr His Gln Arg Ser Lys 
         275                280                285
Ser Asp Ala Thr Ala Ser Ile Ser Leu Ser Ser Asn Leu Lys Arg Thr 
     290                295                300
Ala Ser Asn Pro Lys Val Glu Asn Glu Asp Glu Glu Leu Ser Ser Ser 
 305                310                315                320
Thr Glu Ser Ile Asp Asn Ser Phe Ser Ser Pro Val Arg Leu Ala Pro 
                 325                330                335
Glu Arg Glu Phe Ile Lys Ser Leu Met Ala Ile Gly Lys Arg Leu Ala 
             340                345                350
Thr Leu Pro Thr Lys Glu Gln Lys Thr Gln Arg Leu Ile Ser Glu Leu 
         355                360                365
Ser Leu Leu Asn His Lys Leu Pro Ala Arg Val Trp Leu Pro Thr Ala 
     370                375                380
Gly Phe Asp His His Val Val Arg Val Pro His Thr Gln Ala Val Val 
 385                390                395                400
Leu Asn Ser Lys Asp Lys Ala Pro Tyr Leu Ile Tyr Val Glu Val Leu 
                 405                410                415
Glu Cys Glu Asn Phe Asp Thr Thr Ser Val Pro Ala Arg Ile Pro Glu 
             420                425                430
Asn Arg Ile Arg Ser Thr Arg Ser Val Glu Asn Leu Pro Glu Cys Gly 
         435                440                445
Ile Thr His Glu Gln Arg Ala Gly Ser Phe Ser Thr Val Pro Asn Tyr 
     450                455                460
Asp Asn Asp Asp Glu Ala Trp Ser Val Asp Asp Ile Gly Glu Leu Gln 
 465                470                475                480
Val Glu Leu Pro Glu Val His Thr Asn Ser Cys Asp Asn Ile Ser Gln 
                 485                490                495
Phe Ser Val Asp Ser Ile Thr Ser Gln Glu Ser Lys Glu Pro Val Phe 
             500                505                510
Ile Ala Ala Gly Asp Ile Arg Arg Arg Leu Ser Glu Gln Leu Ala His 
         515                520                525
Thr Pro Thr Ala Phe Lys Arg Asp Pro Glu Asp Pro Ser Ala Val Ala 
     530                535                540
Leu Lys Glu Pro Trp Gln Glu Lys Val Arg Arg Ile Arg Glu Gly Ser 
 545                550                555                560
Pro Tyr Gly His Leu Pro Asn Trp Arg Leu Leu Ser Val Ile Val Lys 
                 565                570                575
Cys Gly Asp Asp Leu Arg Gln Glu Leu Leu Ala Phe Gln Val Leu Lys 
             580                585                590
Gln Leu Gln Ser Ile Trp Glu Gln Glu Arg Val Pro Leu Trp Ile Lys 
         595                600                605
Pro Tyr Lys Ile Leu Val Ile Ser Ala Asp Ser Gly Met Ile Glu Pro 
     610                615                620
Val Val Asn Ala Val Ser Ile His Gln Val Lys Lys Gln Ser Gln Leu 
 625                630                635                640
Ser Leu Leu Asp Tyr Phe Leu Gln Glu His Gly Ser Tyr Thr Thr Glu 
                 645                650                655
Ala Phe Leu Ser Ala Gln Arg Asn Phe Val Gln Ser Cys Ala Gly Tyr 
             660                665                670
Cys Leu Val Cys Tyr Leu Leu Gln Val Lys Asp Arg His Asn Gly Asn 
         675                680                685
Ile Leu Leu Asp Ala Glu Gly His Ile Ile His Ile Asp Phe Gly Phe 
     690                695                700
Ile Leu Ser Ser Ser Pro Arg Asn Leu Gly Phe Glu Thr Ser Ala Phe 
 705                710                715                720
Lys Leu Thr Thr Glu Phe Val Asp Val Met Gly Gly Leu Asp Gly Asp 
                 725                730                735
Met Phe Asn Tyr Tyr Lys Met Leu Met Leu Gln Gly Leu Ile Ala Ala 
             740                745                750
Arg Lys His Met Asp Lys Val Val Gln Ile Val Glu Ile Met Gln Gln 
         755                760                765
Gly Ser Gln Leu Pro Cys Phe His Gly Ser Ser Thr Ile Arg Asn Leu 
     770                775                780
Lys Glu Arg Phe His Met Ser Met Thr Glu Glu Gln Leu Gln Leu Leu 
 785                790                795                800
Val Glu Gln Met Val Asp Gly Ser Met Arg Ser Ile Thr Thr Lys Leu 
                 805                810                815
Tyr Asp Gly Phe Gln Tyr Leu Thr Asn Gly Ile Met 
             820                825



<210> 6779
<211> 405
<212> DNA
<213> Rattus norvegicus
<308> AI102562
<400> 6779

ggcttttat  attcacatg  tcggtagaa  acggggttt  gtaaactgg  tggaggtgt  60
cggcaagac  ctgagttgg  ccggaaatt  tttacacct  agggcagca  cactgttcg  120
cacttcagg  acagcacgt  cacttgtcc  aggcacctt  gcaaacaca  ccctgggca  180
atttggagc  gcccacggg  cagcaggag  agcagctct  cttgcagga  gtgcatttg  240
agtttttgc  gccgcagga  ctggaccag  tgcaggagc  gccggtgga  caggaccag  300
tggggtcca  tccgagatc  ggtgaatct  gagcaacgg  gtaagctac  agaaggcag  360
ccctcgtgc  gaattcttg  cctctaggg  caaattccc  atagg  405



<210> 6780
<211> 61
<212> PRT
<213> Rattus norvegicus
<308> P02803
<400> 6780

Met Asp Pro Asn Cys Ser Cys Ser Thr Gly Gly Ser Cys Thr Cys Ser 
  1               5                  10                  15
Ser Ser Cys Gly Cys Lys Asn Cys Lys Cys Thr Ser Cys Lys Lys Ser 
             20                  25                  30
Cys Cys Ser Cys Cys Pro Val Gly Cys Ser Lys Cys Ala Gln Gly Cys 
         35                  40                  45
Val Cys Lys Gly Ala Ser Asp Lys Cys Thr Cys Cys Ala 
     50                  55                  60



<210> 6781
<211> 625
<212> DNA
<213> Homo sapiens
<308> BG260238
<400> 6781

gctgtggga  gaggccgag  gtggcttta  cttgcactc  tgcaaaaga  actggcaga  60
tatctgaaa  tgcttatag  caataaaca  ctcttaagc  agttctatg  gcctgaggc  120
ttaatgatg  aggaagaag  gatggtgat  gttggtctg  tggtgggac  caatgttct  180
gatgccaat  tctgtttga  aggagaaga  ttggattct  aggtggagt  atagatttt  240
ccctctacc  taaggatgt  caggatctt  atggtggca  ggagcatga  agaattact  300
atgtccttg  tcaaaaaaa  tatgtggaa  aacttaacc  gcacttgag  tgcacagtt  360
gggatcttc  aaccaagat  gatggcttg  aaaagacta  ctcaaagct  caagaagag  420
tttcagctg  aacagaccg  atttgctca  ttcaagaag  acagcagca  ttaagagaa  480
aaaatgaat  aattcgaga  agaagtgaa  agagtgtag  gataacaaa  caggatacc  540
aagttgagc  ggagactta  aagcaaact  ggcaaggtc  ggatgaaat  tacagtgat  600
tgtggaagc  gtaaagagg  gaaaa  625



<210> 6782
<211> 522
<212> DNA
<213> Rattus norvegicus
<308> AI102620
<400> 6782

aaacaccaa  ataggtaca  atactataa  attggttca  aggggtaaa  attttaatt  60
aaatatctc  atatattta  aataacaaa  gatacattt  agccaaatt  tcttaaccc  120
gagtttttt  ttgtagcat  tgcttacat  gtaaggtgc  aataggagt  agcccttaa  180
ccctggaag  cttaggaat  atagtcaca  agcacatag  atttcattg  gagagtgaa  240
tttggtaga  gaaaaatct  taggacacc  gaggtagta  aaactggaa  aaacagcag  300
agacgttat  tacaacttg  gtaccaaat  acattaaaa  cacaaaaat  attacacaa  360
acaattttc  gtccagctt  gatccaaag  aaacaagaa  atcacatca  atttgcatc  420
aaaacaaaa  agcacaatt  ccagcaagc  gaggggact  caaacaaac  caaacacgg  480
gggtcctga  atctgggga  agtctgagt  tgaaatgtg  ca  522



<210> 6783
<211> 1493
<212> PRT
<213> Rattus norvegicus
<308> AAD25049
<400> 6783

Met Ala Ala Ala Ala Gly Asp Arg Ala Ser Ser Ser Gly Phe Pro Gly 
  1               5                  10                  15
Ala Ala Ala Ala Ser Pro Glu Ala Gly Gly Gly Gly Gly Gly Gly Gly 
             20                  25                  30
Ala Leu Gln Gly Ser Gly Ala Pro Ala Ala Gly Ala Ala Gly Leu Leu 
         35                  40                  45
Arg Glu Pro Gly Ser Ala Gly Arg Glu Arg Ala Asp Trp Arg Arg Arg 
     50                  55                  60
Gln Leu Arg Lys Val Arg Ser Val Glu Leu Asp Gln Leu Pro Glu Gln 
 65                  70                  75                  80
Pro Leu Phe Leu Ala Ala Ala Ser Pro Pro Cys Pro Ser Thr Ser Pro 
                 85                  90                  95
Ser Pro Glu Pro Ala Asp Ala Ala Ala Gly Ala Ser Arg Phe Gln Pro 
             100                105                110
Ala Ala Gly Pro Pro Pro Pro Gly Ala Ala Ser Arg Cys Gly Ser His 
         115                120                125
Ser Ala Glu Leu Ala Ala Ala Arg Asp Ser Gly Ala Arg Ser Pro Ala 
     130                135                140
Gly Ala Glu Pro Pro Ser Ala Ala Ala Pro Ser Gly Arg Glu Met Glu 
 145                150                155                160
Asn Lys Glu Thr Leu Lys Gly Leu His Lys Met Glu Asp Arg Pro Glu 
                 165                170                175
Glu Arg Met Ile Arg Glu Lys Leu Lys Ala Thr Cys Met Pro Ala Trp 
             180                185                190
Lys His Glu Trp Leu Glu Arg Arg Asn Arg Arg Gly Pro Val Val Val 
         195                200                205
Lys Pro Ile Pro Ile Lys Gly Asp Gly Ser Glu Val Asn Asn Leu Ala 
     210                215                220
Ala Glu Pro Gln Gly Glu Gly Gln Ala Gly Ser Ala Ala Pro Ala Pro 
 225                230                235                240
Lys Gly Arg Arg Ser Pro Ser Pro Gly Ser Ser Pro Ser Gly Arg Ser 
                 245                250                255
Val Lys Pro Glu Ser Pro Gly Val Arg Arg Lys Arg Val Ser Pro Val 
             260                265                270
Pro Phe Gln Ser Gly Arg Ile Thr Pro Pro Arg Arg Ala Pro Ser Pro 
         275                280                285
Asp Gly Phe Ser Pro Tyr Ser Pro Glu Glu Thr Ser Arg Arg Val Asn 
     290                295                300
Lys Val Met Arg Ala Arg Leu Tyr Leu Leu Gln Gln Ile Gly Pro Asn 
 305                310                315                320
Ser Phe Leu Ile Gly Gly Asp Ser Pro Asp Asn Lys Tyr Arg Val Phe 
                 325                330                335
Ile Gly Pro Gln Asn Cys Ser Cys Gly Arg Gly Ala Phe Cys Ile His 
             340                345                350
Leu Leu Phe Val Met Leu Arg Val Phe Gln Leu Glu Pro Ser Asp Pro 
         355                360                365
Met Leu Trp Arg Lys Thr Leu Lys Asn Phe Glu Val Glu Ser Leu Phe 
     370                375                380
Gln Lys Tyr His Ser Arg Arg Ser Ser Arg Ile Lys Ala Pro Ser Arg 
 385                390                395                400
Asn Thr Ile Gln Lys Phe Val Ser Arg Met Ser Asn Ser His Thr Leu 
                 405                410                415
Ser Ser Ser Ser Thr Ser Thr Ser Ser Ser Glu Asn Ser Ile Lys Asp 
             420                425                430
Glu Glu Glu Gln Met Cys Pro Ile Cys Leu Leu Gly Met Leu Asp Glu 
         435                440                445
Glu Ser Leu Thr Val Cys Glu Asp Gly Cys Arg Asn Lys Leu His His 
     450                455                460
His Cys Met Ser Ile Trp Ala Glu Glu Cys Arg Arg Asn Arg Glu Pro 
 465                470                475                480
Leu Ile Cys Pro Leu Cys Arg Ser Lys Trp Arg Ser His Asp Phe Tyr 
                 485                490                495
Ser His Glu Leu Ser Ser Pro Val Glu Ser Pro Ala Ser Leu Arg Ala 
             500                505                510
Val Gln Gln Pro Ser Ser Pro Gln Gln Pro Val Ala Gly Ser Gln Arg 
         515                520                525
Arg Asn Gln Glu Ser Ser Phe Asn Leu Thr His Phe Gly Thr Gln Gln 
     530                535                540
Ile Pro Ser Ala Tyr Lys Asp Leu Ala Glu Pro Trp Ile Gln Val Phe 
 545                550                555                560
Gly Met Glu Leu Val Gly Cys Leu Phe Ser Arg Asn Trp Asn Val Arg 
                 565                570                575
Glu Met Ala Leu Arg Arg Leu Ser His Asp Val Ser Gly Ala Leu Leu 
             580                585                590
Leu Ala Asn Gly Glu Ser Thr Gly Asn Ser Gly Gly Gly Ser Gly Gly 
         595                600                605
Ser Leu Ser Ala Gly Ala Ala Ser Gly Ser Ser Gln Pro Ser Ile Ser 
     610                615                620
Gly Asp Val Val Glu Ala Cys Cys Ser Val Leu Ser Ile Val Cys Ala 
 625                630                635                640
Asp Pro Val Tyr Lys Val Tyr Val Ala Ala Leu Lys Thr Leu Arg Ala 
                 645                650                655
Met Leu Val Tyr Thr Pro Cys His Ser Leu Ala Glu Arg Ile Lys Leu 
             660                665                670
Gln Arg Leu Leu Arg Pro Val Val Asp Thr Ile Leu Val Lys Cys Ala 
         675                680                685
Asp Ala Asn Ser Arg Thr Ser Gln Leu Ser Ile Ser Thr Val Leu Glu 
     690                695                700
Leu Cys Lys Gly Gln Ala Gly Glu Leu Ala Val Gly Arg Glu Ile Leu 
 705                710                715                720
Lys Ala Gly Ser Ile Gly Val Gly Gly Val Asp Tyr Val Leu Ser Cys 
                 725                730                735
Ile Leu Gly Asn Gln Ala Glu Ser Asn Asn Trp Gln Glu Leu Leu Gly 
             740                745                750
Arg Leu Cys Leu Ile Asp Arg Leu Leu Leu Glu Phe Pro Ala Glu Phe 
         755                760                765
Tyr Pro His Ile Val Ser Thr Asp Val Ser Gln Ala Glu Pro Val Glu 
     770                775                780
Ile Arg Tyr Lys Lys Leu Leu Ser Leu Leu Thr Phe Ala Leu Gln Ser 
 785                790                795                800
Ile Asp Asn Ser His Ser Met Val Gly Lys Leu Ser Arg Arg Ile Tyr 
                 805                810                815
Leu Ser Ser Ala Arg Met Val Thr Ala Val Pro Ala Val Phe Ser Lys 
             820                825                830
Leu Val Thr Met Leu Asn Ala Ser Gly Ser Thr His Phe Thr Arg Met 
         835                840                845
Arg Arg Arg Leu Met Ala Ile Ala Asp Glu Val Glu Ile Ala Glu Val 
     850                855                860
Ile Gln Leu Gly Val Glu Asp Thr Val Asp Gly His Gln Asp Ser Leu 
 865                870                875                880
Gln Ala Val Ala Pro Thr Ser Cys Leu Glu Asn Ser Ser Leu Glu His 
                 885                890                895
Thr Val His Arg Glu Lys Thr Gly Lys Gly Leu Ser Ala Thr Arg Leu 
             900                905                910
Ser Ala Ser Ser Glu Asp Ile Ser Asp Arg Leu Ala Gly Val Ser Val 
         915                920                925
Gly Leu Pro Ser Ser Thr Thr Thr Glu Gln Pro Lys Pro Ala Val Gln 
     930                935                940
Thr Lys Gly Arg Pro His Ser Gln Cys Leu Asn Ser Ser Pro Leu Ser 
 945                950                955                960
His Ala Gln Leu Met Phe Pro Ala Pro Ser Ala Pro Cys Ser Ser Ala 
                 965                970                975
Pro Ser Val Pro Asp Ile Ser Lys His Arg Pro Gln Ala Phe Val Pro 
             980                985                990
Cys Lys Ile Pro Ser Ala Ser Pro Gln Thr Gln Arg Lys Phe Ser Leu 
         995                1000                1005
Gln Phe Gln Arg Asn Cys Ser Glu His Arg Asp Ser Asp Gln Leu Ser 
     1010                1015                1020
Pro Val Phe Thr Gln Ser Arg Pro Pro Pro Ser Ser Asn Ile His Arg 
 1025                1030                1035                1040
Pro Lys Pro Ser Arg Pro Val Pro Gly Ser Thr Ser Lys Leu Gly Asp 
                 1045                1050                1055
Ala Thr Lys Ser Ser Met Thr Leu Asp Leu Gly Ser Ala Ser Arg Cys 
             1060                1065                1070
Asp Asp Ser Phe Gly Gly Gly Gly Asn Ser Gly Asn Ala Val Ile Pro 
         1075                1080                1085
Ser Asp Glu Thr Val Phe Thr Pro Val Glu Asp Lys Cys Arg Leu Asp 
     1090                1095                1100
Val Asn Thr Glu Leu Asn Ser Ser Ile Glu Asp Leu Leu Glu Ala Ser 
 1105                1110                1115                1120
Met Pro Ser Ser Asp Thr Thr Val Thr Phe Lys Ser Glu Val Ala Val 
                 1125                1130                1135
Leu Ser Pro Glu Lys Ala Glu Asn Asp Asp Thr Tyr Lys Asp Asp Val 
             1140                1145                1150
Asn His Asn Gln Lys Cys Lys Glu Lys Met Glu Ala Glu Glu Glu Glu 
         1155                1160                1165
Ala Leu Ala Ile Ala Met Ala Met Ser Ala Ser Gln Asp Ala Leu Pro 
     1170                1175                1180
Ile Val Pro Gln Leu Gln Val Glu Asn Gly Glu Asp Ile Ile Ile Ile 
 1185                1190                1195                1200
Gln Gln Asp Thr Pro Glu Thr Leu Pro Gly His Thr Lys Ala Lys Gln 
                 1205                1210                1215
Pro Tyr Arg Glu Asp Ala Glu Trp Leu Lys Gly Gln Gln Ile Gly Leu 
             1220                1225                1230
Gly Ala Phe Ser Ser Cys Tyr Gln Ala Gln Asp Val Gly Thr Gly Thr 
         1235                1240                1245
Leu Met Ala Val Lys Gln Val Thr Tyr Val Arg Asn Thr Ser Ser Glu 
     1250                1255                1260
Gln Glu Glu Val Val Glu Ala Leu Arg Glu Glu Ile Arg Met Met Gly 
 1265                1270                1275                1280
His Leu Asn His Pro Asn Ile Ile Arg Met Leu Gly Ala Thr Cys Glu 
                 1285                1290                1295
Lys Ser Asn Tyr Asn Leu Phe Ile Glu Trp Met Ala Gly Gly Ser Val 
             1300                1305                1310
Ala His Leu Leu Ser Lys Tyr Gly Ala Phe Lys Glu Ser Val Val Ile 
         1315                1320                1325
Asn Tyr Thr Glu Gln Leu Leu Arg Gly Leu Ser Tyr Leu His Glu Asn 
     1330                1335                1340
Gln Ile Ile His Arg Asp Val Lys Gly Ala Asn Leu Leu Ile Asp Ser 
 1345                1350                1355                1360
Thr Gly Gln Arg Leu Arg Ile Ala Asp Phe Gly Ala Ala Ala Arg Leu 
                 1365                1370                1375
Ala Ser Lys Gly Thr Gly Ala Gly Glu Phe Gln Gly Gln Leu Leu Gly 
             1380                1385                1390
Thr Ile Ala Phe Met Ala Pro Glu Val Leu Arg Gly Gln Gln Tyr Gly 
         1395                1400                1405
Arg Ser Cys Asp Val Trp Ser Val Gly Cys Ala Ile Ile Glu Met Ala 
     1410                1415                1420
Cys Ala Lys Pro Pro Trp Asn Ala Glu Lys His Ser Asn His Leu Ala 
 1425                1430                1435                1440
Leu Ile Phe Lys Ile Ala Ser Ala Thr Thr Ala Pro Ser Ile Pro Ser 
                 1445                1450                1455
His Leu Ser Pro Gly Leu Arg Asp Val Ala Val Arg Cys Leu Glu Leu 
             1460                1465                1470
Gln Pro Gln Asp Arg Pro Pro Ser Arg Glu Leu Leu Lys His Pro Val 
         1475                1480                1485
Phe Arg Thr Thr Trp 
     1490



<210> 6784
<211> 313
<212> DNA
<213> Homo sapiens
<308> AA834992
<400> 6784

tttgttcaa  aacttttat  tactataaa  acaaaaaca  caaaatagg  acaaatact  60
taaaatcgg  tcaatgggg  aaaaatttt  attaaaata  ctcaatata  ttaaaataa  120
aaaggatac  tttaagcca  attttctta  cccagagat  ttttttttt  ttttttgta  180
catttgctt  cacagtaag  tgctaatag  agttagccc  taagccctg  aaatcttag  240
aatcatagt  acacagcaa  tataatttc  ttgtgaaag  gaactttgg  agaagaaaa  300
tctatagga  acc  313



<210> 6785
<211> 1495
<212> PRT
<213> Homo sapiens
<308> Q13233
<400> 6785

Pro Ser Pro Glu Ala Gly Gly Gly Gly Gly Ala Leu Lys Ala Ser Ser 
  1               5                  10                  15
Ala Arg Ala Ala Ala Ala Gly Leu Leu Arg Glu Ala Gly Ser Gly Gly 
             20                  25                  30
Arg Glu Arg Ala Asp Trp Arg Arg Arg Gln Leu Arg Lys Val Arg Ser 
         35                  40                  45
Val Glu Leu Asp Gln Leu Pro Glu Gln Pro Leu Phe Leu Ala Ala Ser 
     50                  55                  60
Pro Pro Ala Ser Ser Thr Ser Pro Ser Pro Glu Pro Ala Asp Ala Ala 
 65                  70                  75                  80
Gly Ser Gly Thr Gly Phe Gln Pro Val Ala Val Pro Pro Pro His Gly 
                 85                  90                  95
Ala Ala Ser Arg Arg Gly Ala His Leu Thr Glu Ser Val Ala Ala Pro 
             100                105                110
Asp Ser Gly Ala Ser Ser Pro Ala Ala Ala Glu Pro Gly Glu Lys Arg 
         115                120                125
Ala Pro Ala Ala Glu Pro Ser Pro Ala Ala Ala Pro Ala Gly Arg Glu 
     130                135                140
Met Glu Asn Lys Glu Thr Leu Lys Gly Leu His Lys Met Asp Asp Arg 
 145                150                155                160
Pro Glu Glu Arg Met Ile Arg Glu Lys Leu Lys Ala Thr Cys Met Pro 
                 165                170                175
Ala Trp Lys His Glu Trp Leu Glu Arg Arg Asn Arg Arg Gly Pro Val 
             180                185                190
Val Val Lys Pro Ile Pro Val Lys Gly Asp Gly Ser Glu Met Asn His 
         195                200                205
Leu Ala Ala Glu Ser Pro Gly Glu Val Gln Ala Ser Ala Ala Ser Pro 
     210                215                220
Ala Ser Lys Gly Arg Arg Ser Pro Ser Pro Gly Asn Ser Pro Ser Gly 
 225                230                235                240
Arg Thr Val Lys Ser Glu Ser Pro Gly Val Arg Arg Lys Arg Val Ser 
                 245                250                255
Pro Val Pro Phe Gln Ser Gly Arg Ile Thr Pro Pro Arg Arg Ala Pro 
             260                265                270
Ser Pro Asp Gly Phe Ser Pro Tyr Ser Pro Glu Glu Thr Asn Arg Arg 
         275                280                285
Val Asn Lys Val Met Arg Ala Arg Leu Tyr Leu Leu Gln Gln Ile Gly 
     290                295                300
Pro Asn Ser Phe Leu Ile Gly Gly Asp Ser Pro Asp Asn Lys Tyr Arg 
 305                310                315                320
Val Phe Ile Gly Pro Gln Asn Cys Ser Cys Ala His Gly Thr Phe Cys 
                 325                330                335
Ile His Leu Leu Phe Val Met Leu Arg Val Phe Gln Leu Glu Pro Ser 
             340                345                350
Asp Pro Met Leu Trp Arg Lys Thr Leu Lys Asn Phe Glu Val Glu Ser 
         355                360                365
Leu Phe Gln Lys Tyr His Ser Arg Arg Ser Ser Arg Ile Lys Ala Pro 
     370                375                380
Ser Arg Asn Thr Ile Gln Lys Phe Val Ser Arg Met Ser Asn Ser His 
 385                390                395                400
Thr Leu Ser Ser Ser Ser Thr Ser Thr Ser Ser Ser Glu Asn Ser Ile 
                 405                410                415
Lys Asp Glu Glu Glu Gln Met Cys Pro Ile Cys Leu Leu Gly Met Leu 
             420                425                430
Asp Glu Glu Ser Leu Thr Val Cys Glu Asp Gly Cys Arg Asn Lys Leu 
         435                440                445
His His His Cys Met Ser Ile Trp Ala Glu Glu Cys Arg Arg Asn Arg 
     450                455                460
Glu Pro Leu Ile Cys Pro Leu Cys Arg Ser Lys Trp Arg Ser His Asp 
 465                470                475                480
Phe Tyr Ser His Glu Leu Ser Ser Pro Val Asp Ser Pro Ser Ser Leu 
                 485                490                495
Arg Ala Ala Gln Gln Gln Thr Val Gln Gln Gln Pro Leu Ala Gly Ser 
             500                505                510
Arg Arg Asn Gln Glu Ser Asn Phe Asn Leu Thr His Tyr Gly Thr Gln 
         515                520                525
Gln Ile Pro Pro Ala Tyr Lys Asp Leu Ala Glu Pro Trp Ile Gln Val 
     530                535                540
Phe Gly Met Glu Leu Val Gly Cys Leu Phe Ser Arg Asn Trp Asn Val 
 545                550                555                560
Arg Glu Met Ala Leu Arg Arg Leu Ser His Asp Val Ser Gly Ala Leu 
                 565                570                575
Leu Leu Ala Asn Gly Glu Ser Thr Gly Asn Ser Gly Gly Ser Ser Gly 
             580                585                590
Ser Ser Pro Ser Gly Gly Ala Thr Ser Gly Ser Ser Gln Thr Ser Ile 
         595                600                605
Ser Gly Asp Val Val Glu Ala Cys Cys Ser Val Leu Ser Met Val Cys 
     610                615                620
Ala Asp Pro Val Tyr Lys Val Tyr Val Ala Ala Leu Lys Thr Leu Arg 
 625                630                635                640
Ala Met Leu Val Tyr Thr Pro Cys His Ser Leu Ala Glu Arg Ile Lys 
                 645                650                655
Leu Gln Arg Leu Leu Gln Pro Val Val Asp Thr Ile Leu Val Lys Cys 
             660                665                670
Ala Asp Ala Asn Ser Arg Thr Ser Gln Leu Ser Ile Ser Thr Leu Leu 
         675                680                685
Glu Leu Cys Lys Gly Gln Ala Gly Glu Leu Ala Val Gly Arg Glu Ile 
     690                695                700
Leu Lys Ala Gly Ser Ile Gly Ile Gly Gly Val Asp Tyr Val Leu Asn 
 705                710                715                720
Cys Ile Leu Gly Asn Gln Thr Glu Ser Asn Asn Trp Gln Glu Leu Leu 
                 725                730                735
Gly Arg Leu Cys Leu Ile Asp Arg Leu Leu Leu Glu Phe Pro Ala Glu 
             740                745                750
Phe Tyr Pro His Ile Val Ser Thr Asp Val Ser Gln Ala Glu Pro Val 
         755                760                765
Glu Ile Arg Tyr Lys Lys Leu Leu Ser Leu Leu Thr Phe Ala Leu Gln 
     770                775                780
Ser Ile Asp Asn Ser His Ser Met Val Gly Lys Leu Ser Arg Arg Ile 
 785                790                795                800
Tyr Leu Ser Ser Ala Arg Met Val Thr Thr Val Pro His Val Phe Ser 
                 805                810                815
Lys Leu Leu Glu Met Leu Ser Val Ser Ser Val Ser Thr His Phe Thr 
             820                825                830
Arg Met Arg Arg Arg Leu Met Ala Tyr Ala Asp Glu Val Glu Ile Ala 
         835                840                845
Glu Ala Ile Gln Leu Gly Val Glu Asp Thr Leu Gln Arg Gln Gln His 
     850                855                860
Asn Ser Phe Cys Arg His Leu Phe Pro Thr Thr Ile Trp Lys Pro Gln 
 865                870                875                880
Arg Thr Val Pro Leu Glu Cys Thr Val His Leu Glu Lys Thr Gly Lys 
                 885                890                895
Gly Leu Cys Ala Thr Lys Leu Ser Ala Ser Ser Glu Asp Ile Ser Glu 
             900                905                910
Arg Leu Ala Arg Ile Ser Val Gly Pro Ser Ser Ser Thr Thr Thr Thr 
         915                920                925
Thr Thr Thr Thr Glu Gln Pro Lys Pro Met Val Gln Thr Lys Gly Arg 
     930                935                940
Pro His Ser Gln Cys Leu Asn Ser Ser Pro Leu Ser His His Ser Gln 
 945                950                955                960
Leu Met Phe Pro Ala Leu Ser Thr Pro Ser Ser Ser Thr Pro Ser Val 
                 965                970                975
Pro Ala Gly Thr Ala Thr Asp Val Ser Lys His Arg Leu Gln Gly Phe 
             980                985                990
Ile Pro Cys Arg Ile Pro Ser Ala Ser Pro Gln Thr Gln Arg Lys Phe 
         995                1000                1005
Ser Leu Gln Phe His Arg Asn Cys Pro Glu Asn Lys Asp Ser Asp Lys 
     1010                1015                1020
Leu Ser Pro Val Phe Thr Gln Ser Arg Pro Leu Pro Ser Ser Asn Ile 
 1025                1030                1035                1040
His Arg Pro Lys Pro Ser Arg Pro Thr Pro Gly Asn Thr Ser Lys Gln 
                 1045                1050                1055
Gly Asp Pro Ser Lys Asn Ser Met Thr Leu Asp Leu Asn Ser Ser Ser 
             1060                1065                1070
Lys Cys Asp Asp Ser Phe Gly Leu Ser Ser Asn Ser Ser Asn Cys Cys 
         1075                1080                1085
Tyr Thr Ser Asp Glu Thr Val Phe Thr Pro Val Glu Glu Lys Cys Arg 
     1090                1095                1100
Leu Asp Val Asn Thr Glu Leu Asn Ser Ser Ile Glu Asp Leu Leu Glu 
 1105                1110                1115                1120
Ala Ser Met Pro Ser Ser Asp Thr Thr Val Thr Phe Lys Ser Glu Val 
                 1125                1130                1135
Ala Val Leu Ser Pro Glu Lys Ala Glu Asn Asp Asp Thr Tyr Lys Asp 
             1140                1145                1150
Asp Val Asn His Asn Gln Lys Cys Lys Glu Lys Met Glu Ala Glu Glu 
         1155                1160                1165
Glu Glu Ala Leu Ala Ile Ala Met Ala Met Ser Ala Ser Gln Val Ala 
     1170                1175                1180
Leu Pro Ile Val Pro Gln Leu Gln Val Glu Asn Gly Glu Asp Ile Ile 
 1185                1190                1195                1200
Ile Ile Gln Gln Asp Thr Pro Glu Thr Leu Pro Gly His Thr Lys Ala 
                 1205                1210                1215
Lys Gln Pro Tyr Arg Glu Asp Thr Glu Trp Leu Lys Gly Gln Gln Ile 
             1220                1225                1230
Gly Leu Gly Ala Phe Ser Ser Cys Tyr Gln Ala Gln Asp Val Gly Thr 
         1235                1240                1245
Gly Thr Leu Met Ala Val Lys Gln Val Thr Tyr Val Arg Asn Thr Ser 
     1250                1255                1260
Ser Glu Gln Glu Glu Val Val Glu Ala Leu Arg Glu Glu Ile Arg Met 
 1265                1270                1275                1280
Met Ser His Leu Asn His Pro Asn Ile Ile Arg Met Leu Gly Ala Thr 
                 1285                1290                1295
Cys Glu Lys Ser Asn Tyr Asn Leu Phe Ile Glu Trp Met Ala Gly Gly 
             1300                1305                1310
Ser Val Ala His Leu Leu Ser Lys Tyr Gly Ala Phe Lys Glu Ser Val 
         1315                1320                1325
Val Ile Asn Tyr Thr Glu Gln Leu Leu Arg Gly Leu Ser Tyr Leu His 
     1330                1335                1340
Glu Asn Gln Ile Ile His Arg Asp Val Lys Gly Ala Asn Leu Leu Ile 
 1345                1350                1355                1360
Asp Ser Thr Gly Gln Arg Leu Arg Ile Ala Asp Phe Gly Ala Ala Ala 
                 1365                1370                1375
Arg Leu Ala Ser Lys Gly Thr Gly Ala Gly Glu Phe Gln Gly Gln Leu 
             1380                1385                1390
Leu Gly Thr Ile Ala Phe Met Ala Pro Glu Val Leu Arg Gly Gln Gln 
         1395                1400                1405
Tyr Gly Arg Ser Cys Asp Val Trp Ser Val Gly Cys Ala Ile Ile Glu 
     1410                1415                1420
Met Ala Cys Ala Lys Pro Pro Trp Asn Ala Glu Lys His Ser Asn His 
 1425                1430                1435                1440
Leu Ala Leu Ile Phe Lys Ile Ala Ser Ala Thr Thr Ala Pro Ser Ile 
                 1445                1450                1455
Pro Ser His Leu Ser Pro Gly Leu Arg Asp Val Ala Leu Arg Cys Leu 
             1460                1465                1470
Glu Leu Gln Pro Gln Asp Arg Pro Pro Ser Arg Glu Leu Leu Lys His 
         1475                1480                1485
Pro Val Phe Arg Thr Thr Trp 
     1490                1495



<210> 6786
<211> 458
<212> DNA
<213> Rattus norvegicus
<308> AI102838
<400> 6786

ccggagctg  ggaccgaat  ttaggcttt  ttgattgac  ggctggcac  gctggagaa  60
ccgacttca  gaagagcag  gggctggca  gaggagggc  gttgagcag  agagcttcc  120
tagccaagt  agagggctg  cacgtctct  cttccaaag  tctcctgct  ctgggagca  180
ggtgatggc  ccaggttag  ggaagtctg  gttgaaagc  ctgccaatg  ctagccgcc  240
cacctcact  gtcccacct  cgatctcgt  cagtttggc  tctcgaaga  agcggccca  300
ggggaagtc  ttgatgtag  catttccac  taaacattg  atgccatcc  gggctactt  360
tgtggcaca  tcggctgta  acagaatca  accagcaca  tccttggca  tgatgtggc  420
ctcgtcaca  gccctggcg  cattgtaga  atactgtc  458



<210> 6787
<211> 424
<212> PRT
<213> Rattus norvegicus
<308> P12007
<400> 6787

Met Ala Thr Ala Val Arg Leu Leu Gly Arg Arg Val Ser Ser Trp Arg 
  1               5                  10                  15
Leu Arg Pro Leu Pro Ser Pro Leu Ala Val Pro Gln Arg Ala His Ser 
             20                  25                  30
Met Leu Pro Val Asp Asp Asp Ile Asn Gly Leu Asn Glu Glu Gln Lys 
         35                  40                  45
Gln Leu Arg His Thr Ile Ser Lys Phe Val Gln Glu Asn Leu Ala Pro 
     50                  55                  60
Lys Ala Gln Glu Ile Asp Gln Ser Asn Asp Phe Lys Asn Leu Arg Glu 
 65                  70                  75                  80
Phe Trp Lys Gln Leu Gly Ser Leu Gly Val Leu Gly Ile Thr Ala Pro 
                 85                  90                  95
Val Gln Tyr Gly Gly Ser Gly Leu Gly Tyr Leu Glu His Val Leu Val 
             100                105                110
Met Glu Glu Ile Ser Arg Ala Ser Ala Ala Val Gly Leu Ser Tyr Gly 
         115                120                125
Ala His Ser Asn Leu Cys Ile Asn Gln Ile Val Arg Asn Gly Asn Glu 
     130                135                140
Ala Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ile Ser Gly Glu Phe Ile 
 145                150                155                160
Gly Ala Leu Ala Met Ser Glu Pro Asn Ala Gly Ser Asp Val Val Ser 
                 165                170                175
Met Arg Leu Lys Ala Glu Lys Lys Gly Asp His Tyr Val Leu Asn Gly 
             180                185                190
Asn Lys Phe Trp Ile Thr Asn Gly Pro Asp Ala Asp Val Leu Val Val 
         195                200                205
Tyr Ala Lys Thr Asp Leu Thr Ala Val Pro Ala Ser Arg Gly Ile Thr 
     210                215                220
Ala Phe Ile Val Glu Lys Asp Met Pro Gly Phe Ser Thr Ser Lys Lys 
 225                230                235                240
Leu Asp Lys Leu Gly Met Arg Gly Ser Asn Thr Cys Glu Leu Val Phe 
                 245                250                255
Glu Asp Cys Lys Val Pro Ala Ala Asn Ile Leu Ser Gln Glu Ser Lys 
             260                265                270
Gly Val Tyr Val Leu Met Ser Gly Leu Asp Leu Glu Arg Leu Val Leu 
         275                280                285
Ala Gly Gly Pro Leu Gly Ile Met Gln Ala Val Leu Asp His Thr Ile 
     290                295                300
Pro Tyr Leu His Val Arg Glu Ala Phe Gly Gln Lys Ile Gly Gln Phe 
 305                310                315                320
Gln Leu Met Gln Gly Lys Met Ala Asp Met Tyr Thr Arg Leu Met Ala 
                 325                330                335
Cys Arg Gln Tyr Val Tyr Asn Val Ala Arg Ala Cys Asp Glu Gly His 
             340                345                350
Ile Thr Ala Lys Asp Cys Ala Gly Val Ile Leu Tyr Thr Ala Glu Cys 
         355                360                365
Ala Thr Gln Val Ala Leu Asp Gly Ile Gln Cys Leu Gly Gly Asn Gly 
     370                375                380
Tyr Ile Asn Asp Phe Pro Met Gly Arg Phe Leu Arg Asp Ala Lys Leu 
 385                390                395                400
Tyr Glu Ile Gly Gly Gly Thr Ser Glu Val Arg Arg Leu Val Ile Gly 
                 405                410                415
Arg Ala Phe Asn Ala Asp Phe Arg 
             420



<210> 6788
<211> 2562
<212> DNA
<213> Homo sapiens
<308> AK022777
<400> 6788

gttgtgcca  gctgctctg  catgtttgg  acgtgaatc  tccctttgt  cagcctatc  60
atgctatgt  ggctacctg  ccgttagta  tcacctagg  tatccaatc  gctgtcctg  120
tatcagagt  cctgtgttc  agtaactct  attttgctc  gtggcccca  attgcaaga  180
tagtgatgc  ggcatgtca  aatagttct  ttttagtat  tgttattat  gttgatctg  240
tactatgcc  agctcataa  ttaaacttt  tcataagta  gtatgtata  ggaaaaaaa  300
aacatatat  tgggtttcg  ttctatcta  ggtttcagg  atccactgg  gtcttggaa  360
gtatcctcc  aggataagg  aggactagt  tattcccca  acccctccc  cttgctacc  420
tttgctgct  ttctttaat  accctctcc  cctgtggcc  gtttctata  acttggcat  480
ctgtttgct  tctttgttt  gtcaatcac  tcctttctt  tctgcccaa  ccctggttg  540
aggtggcaa  ggctacatc  atgactttc  catgggccg  tttcttcga  atgccaagc  600
gtatgagat  ggggctggg  ccagcgagg  gaggcggct  gtcatcggc  gagccttca  660
tgcagactt  cactagtcc  gagaccctt  gcccccttt  cctgcacct  gtggccttt  720
ttgggaagt  gagatgtgg  ggctttccc  ccctgccca  agcaggccc  cctgcccag  780
tgctcttgt  agccctctg  cctctggat  aggttgagt  ctccacaac  gctcccaag  840
atcatgggc  tcgcagccg  gcctgtgcc  cggctagtg  tgtgtgatt  aaaatggac  900
cagcaggaa  catattgtc  ggggattgt  gggacaagt  ttggtgact  tgtgccctt  960
ctctctaac  tctgagccc  cctcccagg  taggcacct  ggggcatgc  ggtgcccac  1020
tcccagggt  ggcacctgg  ggcatgcag  tacccacct  tttctcttg  gtgaggctc  1080
ggcaaggag  tctctctgc  caagcacag  agaatcatg  cccctctcc  tgaattgga  1140
cttggtaca  gttaagtat  cctaatcct  aaatctgaa  cacttgtgg  tccaagcat  1200
ttggataag  caaattcaa  tttcagtct  ttttctggg  gaaaaaaat  ataaaccta  1260
cctagccag  cgtggtggc  catgcttgt  atcccagca  ttcaggagg  tgagatggg  1320
ggatcacct  aggtcagga  ttcaagacc  gcctggcca  catgtggaa  cctcgcctc  1380
actaaaaat  gaaaaaaat  agttgggca  ggtggtggg  acctgtaat  ccagctact  1440
caggaggct  aggcaggag  attacttga  cccaggagg  ggaggttgc  gtgagccga  1500
cttgtgcca  tgcactcca  cctgggcga  aagggcaaa  ctcttcaaa  aacaaaaca  1560
aacaaaaaa  ccctggccc  tgtttcttc  agtttctag  ggtatcagc  cctagcagc  1620
tatgaacac  tatgcttgc  tggccaggc  aggtggtgt  tgcctgtaa  cccagcact  1680
tgggaggcc  aggcaggtg  atcacttgc  gtcaggagt  caagaccag  ctgtccaac  1740
tggtgaaac  ccatctcta  taaaaatac  aaaattagc  aggggtggt  gtgcacgtc  1800
gtaatccca  ctactcagg  ggctgaggc  ggagaatca  ttgaacccg  gaggtggag  1860
ttgcaatga  ccaatatga  accgctgca  tccagcctg  gccatagag  gagactctg  1920
ctcaaaaaa  gaaagaaaa  taggctggg  acagtgact  atgcctgta  tcccaacac  1980
ttgggaggc  gaggcaggt  gatcacgag  tcaggagtt  aagaccagc  tggccaaga  2040
ggtaaaacc  cgtctctac  aaaaataca  aaattagcc  ggtgtggtg  caggctcct  2100
taatcccag  tacacagaa  actgaggca  gagaatcgc  tgaacgcag  aggcagagg  2160
tgcaggagc  gagatcgcg  cattgcact  cagcctggg  aacagagtg  gactctgtc  2220
caaaaaata  taataaaat  aatgaacac  catgctgct  agtccgcag  ggggcagag  2280
agaggacag  gtgcttttg  gtactgttg  aagactggc  cctcctgta  agcacctct  2340
agcccttgt  caccgccct  ccacgggca  catccagtc  tggccgtgt  accacccac  2400
gctgactgg  cagcaggca  aggccctac  cgagcaggc  ggagttggc  cgcatgact  2460
cagctgagg  tgcctgtgt  catttctcc  gatacccta  ggctaattt  gttataact  2520
cacagtggc  gctgccatt  tgtattaaa  atattgtga  ac  2562



<210> 6789
<211> 423
<212> PRT
<213> Homo sapiens
<308> P26440
<400> 6789

Met Ala Thr Ala Thr Arg Leu Leu Gly Trp Arg Val Ala Ser Trp Arg 
  1               5                  10                  15
Leu Arg Pro Pro Leu Ala Gly Phe Val Ser Gln Arg Ala His Ser Leu 
             20                  25                  30
Leu Pro Val Asp Asp Ala Ile Asn Gly Leu Ser Glu Glu Gln Arg Gln 
         35                  40                  45
Leu Arg Gln Thr Met Ala Lys Phe Leu Gln Glu His Leu Ala Pro Lys 
     50                  55                  60
Ala Gln Glu Ile Asp Arg Ser Asn Glu Phe Lys Asn Leu Arg Glu Phe 
 65                  70                  75                  80
Trp Lys Gln Leu Gly Asn Leu Gly Val Leu Gly Ile Thr Ala Pro Val 
                 85                  90                  95
Gln Tyr Gly Gly Ser Gly Leu Gly Tyr Leu Glu His Val Leu Val Met 
             100                105                110
Glu Glu Ile Ser Arg Ala Ser Gly Ala Val Gly Leu Ser Tyr Gly Ala 
         115                120                125
His Ser Asn Leu Cys Ile Asn Gln Leu Val Arg Asn Gly Asn Glu Ala 
     130                135                140
Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ile Ser Gly Glu Tyr Ile Gly 
 145                150                155                160
Ala Leu Ala Met Ser Glu Pro Asn Ala Gly Ser Asp Val Val Ser Met 
                 165                170                175
Lys Leu Lys Ala Glu Lys Lys Gly Asn His Tyr Ile Leu Asn Gly Asn 
             180                185                190
Lys Phe Trp Ile Thr Asn Gly Pro Asp Ala Asp Val Leu Ile Val Tyr 
         195                200                205
Ala Lys Thr Asp Leu Ala Ala Val Pro Ala Ser Arg Gly Ile Thr Ala 
     210                215                220
Phe Ile Val Glu Lys Gly Met Pro Gly Phe Ser Thr Ser Lys Lys Leu 
 225                230                235                240
Asp Lys Leu Gly Met Arg Gly Ser Asn Thr Cys Glu Leu Ile Phe Glu 
                 245                250                255
Asp Cys Lys Ile Pro Ala Ala Asn Ile Leu Gly His Glu Asn Lys Gly 
             260                265                270
Val Tyr Val Leu Met Ser Gly Leu Asp Leu Glu Arg Leu Val Leu Ala 
         275                280                285
Gly Gly Pro Leu Gly Leu Met Gln Ala Val Leu Asp His Thr Ile Pro 
     290                295                300
Tyr Leu His Val Arg Glu Ala Phe Gly Gln Lys Ile Gly His Phe Gln 
 305                310                315                320
Leu Met Gln Gly Lys Met Ala Asp Met Tyr Thr Arg Leu Met Ala Cys 
                 325                330                335
Arg Gln Tyr Val Tyr Asn Val Ala Lys Ala Cys Asp Glu Gly His Cys 
             340                345                350
Thr Ala Lys Asp Cys Ala Gly Val Ile Leu Tyr Ser Ala Glu Cys Ala 
         355                360                365
Thr Gln Val Ala Leu Asp Gly Ile Gln Cys Phe Gly Gly Asn Gly Tyr 
     370                375                380
Ile Asn Asp Phe Pro Met Gly Arg Phe Leu Arg Asp Ala Lys Leu Tyr 
 385                390                395                400
Glu Ile Gly Ala Gly Thr Ser Glu Val Arg Arg Leu Val Ile Gly Arg 
                 405                410                415
Ala Phe Asn Ala Asp Phe His 
             420



<210> 6790
<211> 458
<212> DNA
<213> Rattus norvegicus
<308> AI102838
<400> 6790

ccggagctg  ggaccgaat  ttaggcttt  ttgattgac  ggctggcac  gctggagaa  60
ccgacttca  gaagagcag  gggctggca  gaggagggc  gttgagcag  agagcttcc  120
tagccaagt  agagggctg  cacgtctct  cttccaaag  tctcctgct  ctgggagca  180
ggtgatggc  ccaggttag  ggaagtctg  gttgaaagc  ctgccaatg  ctagccgcc  240
cacctcact  gtcccacct  cgatctcgt  cagtttggc  tctcgaaga  agcggccca  300
ggggaagtc  ttgatgtag  catttccac  taaacattg  atgccatcc  gggctactt  360
tgtggcaca  tcggctgta  acagaatca  accagcaca  tccttggca  tgatgtggc  420
ctcgtcaca  gccctggcg  cattgtaga  atactgtc  458



<210> 6791
<211> 424
<212> PRT
<213> Rattus norvegicus
<308> P12007
<400> 6791

Met Ala Thr Ala Val Arg Leu Leu Gly Arg Arg Val Ser Ser Trp Arg 
  1               5                  10                  15
Leu Arg Pro Leu Pro Ser Pro Leu Ala Val Pro Gln Arg Ala His Ser 
             20                  25                  30
Met Leu Pro Val Asp Asp Asp Ile Asn Gly Leu Asn Glu Glu Gln Lys 
         35                  40                  45
Gln Leu Arg His Thr Ile Ser Lys Phe Val Gln Glu Asn Leu Ala Pro 
     50                  55                  60
Lys Ala Gln Glu Ile Asp Gln Ser Asn Asp Phe Lys Asn Leu Arg Glu 
 65                  70                  75                  80
Phe Trp Lys Gln Leu Gly Ser Leu Gly Val Leu Gly Ile Thr Ala Pro 
                 85                  90                  95
Val Gln Tyr Gly Gly Ser Gly Leu Gly Tyr Leu Glu His Val Leu Val 
             100                105                110
Met Glu Glu Ile Ser Arg Ala Ser Ala Ala Val Gly Leu Ser Tyr Gly 
         115                120                125
Ala His Ser Asn Leu Cys Ile Asn Gln Ile Val Arg Asn Gly Asn Glu 
     130                135                140
Ala Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ile Ser Gly Glu Phe Ile 
 145                150                155                160
Gly Ala Leu Ala Met Ser Glu Pro Asn Ala Gly Ser Asp Val Val Ser 
                 165                170                175
Met Arg Leu Lys Ala Glu Lys Lys Gly Asp His Tyr Val Leu Asn Gly 
             180                185                190
Asn Lys Phe Trp Ile Thr Asn Gly Pro Asp Ala Asp Val Leu Val Val 
         195                200                205
Tyr Ala Lys Thr Asp Leu Thr Ala Val Pro Ala Ser Arg Gly Ile Thr 
     210                215                220
Ala Phe Ile Val Glu Lys Asp Met Pro Gly Phe Ser Thr Ser Lys Lys 
 225                230                235                240
Leu Asp Lys Leu Gly Met Arg Gly Ser Asn Thr Cys Glu Leu Val Phe 
                 245                250                255
Glu Asp Cys Lys Val Pro Ala Ala Asn Ile Leu Ser Gln Glu Ser Lys 
             260                265                270
Gly Val Tyr Val Leu Met Ser Gly Leu Asp Leu Glu Arg Leu Val Leu 
         275                280                285
Ala Gly Gly Pro Leu Gly Ile Met Gln Ala Val Leu Asp His Thr Ile 
     290                295                300
Pro Tyr Leu His Val Arg Glu Ala Phe Gly Gln Lys Ile Gly Gln Phe 
 305                310                315                320
Gln Leu Met Gln Gly Lys Met Ala Asp Met Tyr Thr Arg Leu Met Ala 
                 325                330                335
Cys Arg Gln Tyr Val Tyr Asn Val Ala Arg Ala Cys Asp Glu Gly His 
             340                345                350
Ile Thr Ala Lys Asp Cys Ala Gly Val Ile Leu Tyr Thr Ala Glu Cys 
         355                360                365
Ala Thr Gln Val Ala Leu Asp Gly Ile Gln Cys Leu Gly Gly Asn Gly 
     370                375                380
Tyr Ile Asn Asp Phe Pro Met Gly Arg Phe Leu Arg Asp Ala Lys Leu 
 385                390                395                400
Tyr Glu Ile Gly Gly Gly Thr Ser Glu Val Arg Arg Leu Val Ile Gly 
                 405                410                415
Arg Ala Phe Asn Ala Asp Phe Arg 
             420



<210> 6792
<211> 2562
<212> DNA
<213> Homo sapiens
<308> AK022777
<400> 6792

gttgtgcca  gctgctctg  catgtttgg  acgtgaatc  tccctttgt  cagcctatc  60
atgctatgt  ggctacctg  ccgttagta  tcacctagg  tatccaatc  gctgtcctg  120
tatcagagt  cctgtgttc  agtaactct  attttgctc  gtggcccca  attgcaaga  180
tagtgatgc  ggcatgtca  aatagttct  ttttagtat  tgttattat  gttgatctg  240
tactatgcc  agctcataa  ttaaacttt  tcataagta  gtatgtata  ggaaaaaaa  300
aacatatat  tgggtttcg  ttctatcta  ggtttcagg  atccactgg  gtcttggaa  360
gtatcctcc  aggataagg  aggactagt  tattcccca  acccctccc  cttgctacc  420
tttgctgct  ttctttaat  accctctcc  cctgtggcc  gtttctata  acttggcat  480
ctgtttgct  tctttgttt  gtcaatcac  tcctttctt  tctgcccaa  ccctggttg  540
aggtggcaa  ggctacatc  atgactttc  catgggccg  tttcttcga  atgccaagc  600
gtatgagat  ggggctggg  ccagcgagg  gaggcggct  gtcatcggc  gagccttca  660
tgcagactt  cactagtcc  gagaccctt  gcccccttt  cctgcacct  gtggccttt  720
ttgggaagt  gagatgtgg  ggctttccc  ccctgccca  agcaggccc  cctgcccag  780
tgctcttgt  agccctctg  cctctggat  aggttgagt  ctccacaac  gctcccaag  840
atcatgggc  tcgcagccg  gcctgtgcc  cggctagtg  tgtgtgatt  aaaatggac  900
cagcaggaa  catattgtc  ggggattgt  gggacaagt  ttggtgact  tgtgccctt  960
ctctctaac  tctgagccc  cctcccagg  taggcacct  ggggcatgc  ggtgcccac  1020
tcccagggt  ggcacctgg  ggcatgcag  tacccacct  tttctcttg  gtgaggctc  1080
ggcaaggag  tctctctgc  caagcacag  agaatcatg  cccctctcc  tgaattgga  1140
cttggtaca  gttaagtat  cctaatcct  aaatctgaa  cacttgtgg  tccaagcat  1200
ttggataag  caaattcaa  tttcagtct  ttttctggg  gaaaaaaat  ataaaccta  1260
cctagccag  cgtggtggc  catgcttgt  atcccagca  ttcaggagg  tgagatggg  1320
ggatcacct  aggtcagga  ttcaagacc  gcctggcca  catgtggaa  cctcgcctc  1380
actaaaaat  gaaaaaaat  agttgggca  ggtggtggg  acctgtaat  ccagctact  1440
caggaggct  aggcaggag  attacttga  cccaggagg  ggaggttgc  gtgagccga  1500
cttgtgcca  tgcactcca  cctgggcga  aagggcaaa  ctcttcaaa  aacaaaaca  1560
aacaaaaaa  ccctggccc  tgtttcttc  agtttctag  ggtatcagc  cctagcagc  1620
tatgaacac  tatgcttgc  tggccaggc  aggtggtgt  tgcctgtaa  cccagcact  1680
tgggaggcc  aggcaggtg  atcacttgc  gtcaggagt  caagaccag  ctgtccaac  1740
tggtgaaac  ccatctcta  taaaaatac  aaaattagc  aggggtggt  gtgcacgtc  1800
gtaatccca  ctactcagg  ggctgaggc  ggagaatca  ttgaacccg  gaggtggag  1860
ttgcaatga  ccaatatga  accgctgca  tccagcctg  gccatagag  gagactctg  1920
ctcaaaaaa  gaaagaaaa  taggctggg  acagtgact  atgcctgta  tcccaacac  1980
ttgggaggc  gaggcaggt  gatcacgag  tcaggagtt  aagaccagc  tggccaaga  2040
ggtaaaacc  cgtctctac  aaaaataca  aaattagcc  ggtgtggtg  caggctcct  2100
taatcccag  tacacagaa  actgaggca  gagaatcgc  tgaacgcag  aggcagagg  2160
tgcaggagc  gagatcgcg  cattgcact  cagcctggg  aacagagtg  gactctgtc  2220
caaaaaata  taataaaat  aatgaacac  catgctgct  agtccgcag  ggggcagag  2280
agaggacag  gtgcttttg  gtactgttg  aagactggc  cctcctgta  agcacctct  2340
agcccttgt  caccgccct  ccacgggca  catccagtc  tggccgtgt  accacccac  2400
gctgactgg  cagcaggca  aggccctac  cgagcaggc  ggagttggc  cgcatgact  2460
cagctgagg  tgcctgtgt  catttctcc  gatacccta  ggctaattt  gttataact  2520
cacagtggc  gctgccatt  tgtattaaa  atattgtga  ac  2562



<210> 6793
<211> 423
<212> PRT
<213> Homo sapiens
<308> P26440
<400> 6793

Met Ala Thr Ala Thr Arg Leu Leu Gly Trp Arg Val Ala Ser Trp Arg 
  1               5                  10                  15
Leu Arg Pro Pro Leu Ala Gly Phe Val Ser Gln Arg Ala His Ser Leu 
             20                  25                  30
Leu Pro Val Asp Asp Ala Ile Asn Gly Leu Ser Glu Glu Gln Arg Gln 
         35                  40                  45
Leu Arg Gln Thr Met Ala Lys Phe Leu Gln Glu His Leu Ala Pro Lys 
     50                  55                  60
Ala Gln Glu Ile Asp Arg Ser Asn Glu Phe Lys Asn Leu Arg Glu Phe 
 65                  70                  75                  80
Trp Lys Gln Leu Gly Asn Leu Gly Val Leu Gly Ile Thr Ala Pro Val 
                 85                  90                  95
Gln Tyr Gly Gly Ser Gly Leu Gly Tyr Leu Glu His Val Leu Val Met 
             100                105                110
Glu Glu Ile Ser Arg Ala Ser Gly Ala Val Gly Leu Ser Tyr Gly Ala 
         115                120                125
His Ser Asn Leu Cys Ile Asn Gln Leu Val Arg Asn Gly Asn Glu Ala 
     130                135                140
Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ile Ser Gly Glu Tyr Ile Gly 
 145                150                155                160
Ala Leu Ala Met Ser Glu Pro Asn Ala Gly Ser Asp Val Val Ser Met 
                 165                170                175
Lys Leu Lys Ala Glu Lys Lys Gly Asn His Tyr Ile Leu Asn Gly Asn 
             180                185                190
Lys Phe Trp Ile Thr Asn Gly Pro Asp Ala Asp Val Leu Ile Val Tyr 
         195                200                205
Ala Lys Thr Asp Leu Ala Ala Val Pro Ala Ser Arg Gly Ile Thr Ala 
     210                215                220
Phe Ile Val Glu Lys Gly Met Pro Gly Phe Ser Thr Ser Lys Lys Leu 
 225                230                235                240
Asp Lys Leu Gly Met Arg Gly Ser Asn Thr Cys Glu Leu Ile Phe Glu 
                 245                250                255
Asp Cys Lys Ile Pro Ala Ala Asn Ile Leu Gly His Glu Asn Lys Gly 
             260                265                270
Val Tyr Val Leu Met Ser Gly Leu Asp Leu Glu Arg Leu Val Leu Ala 
         275                280                285
Gly Gly Pro Leu Gly Leu Met Gln Ala Val Leu Asp His Thr Ile Pro 
     290                295                300
Tyr Leu His Val Arg Glu Ala Phe Gly Gln Lys Ile Gly His Phe Gln 
 305                310                315                320
Leu Met Gln Gly Lys Met Ala Asp Met Tyr Thr Arg Leu Met Ala Cys 
                 325                330                335
Arg Gln Tyr Val Tyr Asn Val Ala Lys Ala Cys Asp Glu Gly His Cys 
             340                345                350
Thr Ala Lys Asp Cys Ala Gly Val Ile Leu Tyr Ser Ala Glu Cys Ala 
         355                360                365
Thr Gln Val Ala Leu Asp Gly Ile Gln Cys Phe Gly Gly Asn Gly Tyr 
     370                375                380
Ile Asn Asp Phe Pro Met Gly Arg Phe Leu Arg Asp Ala Lys Leu Tyr 
 385                390                395                400
Glu Ile Gly Ala Gly Thr Ser Glu Val Arg Arg Leu Val Ile Gly Arg 
                 405                410                415
Ala Phe Asn Ala Asp Phe His 
             420



<210> 6794
<211> 528
<212> DNA
<213> Rattus norvegicus
<308> AI103074
<400> 6794

gccaaaatt  tatttattc  tttcttgca  ttgaagtac  cctcgatga  atccttggc  60
tgagattct  tgccatagt  cttaactac  acgcaactg  aaccaacca  tttccgtgg  120
ttcccctct  gatcgattt  acagaggcc  acccattcc  ctagtttct  gttgtcatc  180
acctttatc  ggttgatct  gtgctcggc  cagagcgcc  ccaccagct  gacatacat  240
ggctcatca  agttggatg  aagcacgca  agatgggct  ggcgcttgt  taaggcttt  300
gcagcttcg  gtatgccac  tgctaggcc  tcgtggatg  gggcggtct  cagcacctc  360
tgtagagca  tgttgacgt  cattacacc  ccagcagct  tgccttcct  ggccatggc  420
gtggattac  ggtgacgcc  aatcttgaa  gcacccgag  ttccgcctc  gcggaactt  480
gcgcctcgt  ccgaattct  ggcctcgag  gccaaattc  ctatagtg  528



<210> 6795
<211> 131
<212> PRT
<213> Rattus norvegicus
<308> P09388
<400> 6795

Ala Glu Glu Gly Ile Ala Ala Gly Gly Val Met Asp Val Asn Thr Ala 
  1               5                  10                  15
Leu Gln Glu Val Leu Lys Thr Ala Leu Ile His Asp Gly Leu Ala Arg 
             20                  25                  30
Gly Ile Arg Glu Ala Ala Lys Ala Leu Asp Lys Arg Gln Ala His Leu 
         35                  40                  45
Cys Val Leu Ala Ser Asn Cys Asp Glu Pro Met Tyr Val Lys Leu Val 
     50                  55                  60
Glu Ala Leu Leu Ala Glu His Gln Ile Asn Leu Ile Lys Val Asp Asp 
 65                  70                  75                  80
Asn Lys Lys Leu Gly Glu Trp Val Gly Leu Cys Lys Ile Asp Arg Glu 
                 85                  90                  95
Gly Lys Pro Arg Lys Val Val Gly Cys Ser Cys Val Val Val Lys Asp 
             100                105                110
Tyr Gly Lys Glu Ser Gln Ala Lys Asp Val Ile Glu Glu Tyr Phe Lys 
         115                120                125
Cys Lys Lys 
     130



<210> 6797
<211> 437
<212> DNA
<213> Rattus norvegicus
<308> AI103874
<400> 6797

gaagtaaac  aaatttatt  tcttcttac  agaatgctt  agttgtttg  ttttgtttc  60
agtcctgtg  cttttaact  tcaccataa  gtattattt  ttacatgtc  ttgacaaag  120
cttgataag  agttcaact  tttgggcaa  gtcactagc  cttatccga  ttagaatac  180
ggacacaga  taagtcaag  caatccatg  catttttat  gagccttta  tttatgagg  240
aaaggaaaa  cagctctct  gaatacttt  catagctgt  ggaaaatat  tgagactta  300
agggagtta  aggggatta  gtttctcaa  agttgagat  aagtaaaca  gctttaaat  360
gtttaaatt  tccagttga  ctttcctta  aatagtaac  agctcgaat  agccacatt  420
ggtttttat  tttgcag  437



<210> 6798
<211> 224
<212> PRT
<213> Rattus norvegicus
<308> AAH02122
<400> 6798

Met Ala Ala Ala Val Pro Gln Arg Ala Trp Thr Val Glu Gln Leu Arg 
  1               5                  10                  15
Ser Glu Gln Leu Pro Lys Lys Asp Ile Ile Lys Phe Leu Gln Asp His 
             20                  25                  30
Gly Ser Asp Ser Phe Leu Ala Glu His Lys Leu Leu Gly Asn Ile Lys 
         35                  40                  45
Asn Val Ala Lys Thr Ala Asn Lys Asp His Leu Val Asn Ala Tyr Asn 
     50                  55                  60
His Leu Phe Glu Ser Lys Arg Phe Lys Gly Thr Glu Thr Ile Ser Lys 
 65                  70                  75                  80
Val Ser Glu Gln Val Lys Asn Val Lys Leu Ser Asp Asp Lys Pro Lys 
                 85                  90                  95
Asp Ser Lys Ser Glu Glu Thr Leu Asp Glu Gly Pro Pro Lys Tyr Thr 
             100                105                110
Lys Ser Ile Leu Lys Lys Gly Asp Lys Thr Asn Phe Pro Lys Lys Gly 
         115                120                125
Asp Val Val His Cys Trp Tyr Thr Gly Thr Leu Pro Asp Gly Thr Val 
     130                135                140
Phe Asp Thr Asn Ile Gln Thr Ser Ser Lys Lys Lys Lys Asn Ala Lys 
 145                150                155                160
Pro Leu Ser Phe Lys Val Gly Val Gly Lys Val Ile Arg Gly Trp Asp 
                 165                170                175
Glu Ala Leu Leu Thr Met Ser Lys Gly Glu Lys Ala Arg Leu Glu Ile 
             180                185                190
Glu Pro Glu Trp Ala Tyr Gly Lys Lys Gly Gln Pro Asp Ala Lys Ile 
         195                200                205
Pro Pro Asn Thr Lys Leu Ile Phe Glu Val Glu Leu Val Asp Ile Asp 
     210                215                220



<210> 6799
<211> 964
<212> DNA
<213> Homo sapiens
<308> M96256
<400> 6799

gaaagcgga  gcagcgggg  aagatggcg  cggccgttc  acagcgggc  tggaccgtg  60
agcagctgc  cagtgagca  ctgcccaag  aggatatta  caagtttct  caggaacac  120
gttcagatt  gtttcttgc  gaacataaa  tattaggaa  cattaaaaa  gtggccaag  180
cagctaaca  ggaccactt  gttacagcc  ataaccatc  ttttgaaac  aagcgtttt  240
agggtactg  aagtataag  aaagtgtct  agcaagtaa  aaatgtgaa  cttaatgaa  300
ataaaccca  agaaaccaa  tctgaagag  ccctggatg  gggtccacc  aaatatact  360
aatctgttc  gaaaaaggg  gataaaacc  actttccca  aaagggaga  gttgttcac  420
gctggtata  aggaacact  caagatggg  ctgtttttg  tactaatat  caaacaagt  480
caaagaaga  gaaaaatgc  aagccttta  gttttaagg  cggagtagg  aaagttatc  540
gaggatggg  tgaagctct  ttgactatg  gtaaaggag  aaaggctcg  ctggagatt  600
aaccagaat  ggcttacgg  aagaaagga  agcctgatg  caaaattcc  ccaaatgca  660
aactcactt  tgaagtgga  ttagtggat  ttgattgaa  taggcagtg  ttcagctct  720
aggatatta  caacaatga  aaaacttgg  cttgaagaa  tttacacaa  tagttagaa  780
ttgttacta  tgtaaagga  gagtcaact  gaaaattca  ggagttaat  aaatttgtt  840
acttggtcc  agcttttga  agataaatc  cttatgaat  cctggtcta  aatactttc  900
tacagctgt  taaaatact  gtcaaggag  actttttcc  tttacctca  gttgtaaac  960
taag  964



<210> 6800
<211> 224
<212> PRT
<213> Homo sapiens
<308> Q00688
<400> 6800

Met Ala Ala Ala Val Pro Gln Arg Ala Trp Thr Val Glu Gln Leu Arg 
  1               5                  10                  15
Ser Glu Gln Leu Pro Lys Lys Asp Ile Ile Lys Phe Leu Gln Glu His 
             20                  25                  30
Gly Ser Asp Ser Phe Leu Ala Glu His Lys Leu Leu Gly Asn Ile Lys 
         35                  40                  45
Asn Val Ala Lys Thr Ala Asn Lys Asp His Leu Val Thr Ala Tyr Asn 
     50                  55                  60
His Leu Phe Glu Thr Lys Arg Phe Lys Gly Thr Glu Ser Ile Ser Lys 
 65                  70                  75                  80
Val Ser Glu Gln Val Lys Asn Val Lys Leu Asn Glu Asp Lys Pro Lys 
                 85                  90                  95
Glu Thr Lys Ser Glu Glu Thr Leu Asp Glu Gly Pro Pro Lys Tyr Thr 
             100                105                110
Lys Ser Val Leu Lys Lys Gly Asp Lys Thr Asn Phe Pro Lys Lys Gly 
         115                120                125
Asp Val Val His Cys Trp Tyr Thr Gly Thr Leu Gln Asp Gly Thr Val 
     130                135                140
Phe Asp Thr Asn Ile Gln Thr Ser Ala Lys Lys Lys Lys Asn Ala Lys 
 145                150                155                160
Pro Leu Ser Phe Lys Val Gly Val Gly Lys Val Ile Arg Gly Trp Asp 
                 165                170                175
Glu Ala Leu Leu Thr Met Ser Lys Gly Glu Lys Ala Arg Leu Glu Ile 
             180                185                190
Glu Pro Glu Trp Ala Tyr Gly Lys Lys Gly Gln Pro Asp Ala Lys Ile 
         195                200                205
Pro Pro Asn Ala Lys Leu Thr Phe Glu Val Glu Leu Val Asp Ile Asp 
     210                215                220



<210> 6801
<211> 437
<212> DNA
<213> Rattus norvegicus
<308> AI103874
<400> 6801

gaagtaaac  aaatttatt  tcttcttac  agaatgctt  agttgtttg  ttttgtttc  60
agtcctgtg  cttttaact  tcaccataa  gtattattt  ttacatgtc  ttgacaaag  120
cttgataag  agttcaact  tttgggcaa  gtcactagc  cttatccga  ttagaatac  180
ggacacaga  taagtcaag  caatccatg  catttttat  gagccttta  tttatgagg  240
aaaggaaaa  cagctctct  gaatacttt  catagctgt  ggaaaatat  tgagactta  300
agggagtta  aggggatta  gtttctcaa  agttgagat  aagtaaaca  gctttaaat  360
gtttaaatt  tccagttga  ctttcctta  aatagtaac  agctcgaat  agccacatt  420
ggtttttat  tttgcag  437



<210> 6802
<211> 224
<212> PRT
<213> Rattus norvegicus
<308> AAH02122
<400> 6802

Met Ala Ala Ala Val Pro Gln Arg Ala Trp Thr Val Glu Gln Leu Arg 
  1               5                  10                  15
Ser Glu Gln Leu Pro Lys Lys Asp Ile Ile Lys Phe Leu Gln Asp His 
             20                  25                  30
Gly Ser Asp Ser Phe Leu Ala Glu His Lys Leu Leu Gly Asn Ile Lys 
         35                  40                  45
Asn Val Ala Lys Thr Ala Asn Lys Asp His Leu Val Asn Ala Tyr Asn 
     50                  55                  60
His Leu Phe Glu Ser Lys Arg Phe Lys Gly Thr Glu Thr Ile Ser Lys 
 65                  70                  75                  80
Val Ser Glu Gln Val Lys Asn Val Lys Leu Ser Asp Asp Lys Pro Lys 
                 85                  90                  95
Asp Ser Lys Ser Glu Glu Thr Leu Asp Glu Gly Pro Pro Lys Tyr Thr 
             100                105                110
Lys Ser Ile Leu Lys Lys Gly Asp Lys Thr Asn Phe Pro Lys Lys Gly 
         115                120                125
Asp Val Val His Cys Trp Tyr Thr Gly Thr Leu Pro Asp Gly Thr Val 
     130                135                140
Phe Asp Thr Asn Ile Gln Thr Ser Ser Lys Lys Lys Lys Asn Ala Lys 
 145                150                155                160
Pro Leu Ser Phe Lys Val Gly Val Gly Lys Val Ile Arg Gly Trp Asp 
                 165                170                175
Glu Ala Leu Leu Thr Met Ser Lys Gly Glu Lys Ala Arg Leu Glu Ile 
             180                185                190
Glu Pro Glu Trp Ala Tyr Gly Lys Lys Gly Gln Pro Asp Ala Lys Ile 
         195                200                205
Pro Pro Asn Thr Lys Leu Ile Phe Glu Val Glu Leu Val Asp Ile Asp 
     210                215                220



<210> 6803
<211> 964
<212> DNA
<213> Homo sapiens
<308> M96256
<400> 6803

gaaagcgga  gcagcgggg  aagatggcg  cggccgttc  acagcgggc  tggaccgtg  60
agcagctgc  cagtgagca  ctgcccaag  aggatatta  caagtttct  caggaacac  120
gttcagatt  gtttcttgc  gaacataaa  tattaggaa  cattaaaaa  gtggccaag  180
cagctaaca  ggaccactt  gttacagcc  ataaccatc  ttttgaaac  aagcgtttt  240
agggtactg  aagtataag  aaagtgtct  agcaagtaa  aaatgtgaa  cttaatgaa  300
ataaaccca  agaaaccaa  tctgaagag  ccctggatg  gggtccacc  aaatatact  360
aatctgttc  gaaaaaggg  gataaaacc  actttccca  aaagggaga  gttgttcac  420
gctggtata  aggaacact  caagatggg  ctgtttttg  tactaatat  caaacaagt  480
caaagaaga  gaaaaatgc  aagccttta  gttttaagg  cggagtagg  aaagttatc  540
gaggatggg  tgaagctct  ttgactatg  gtaaaggag  aaaggctcg  ctggagatt  600
aaccagaat  ggcttacgg  aagaaagga  agcctgatg  caaaattcc  ccaaatgca  660
aactcactt  tgaagtgga  ttagtggat  ttgattgaa  taggcagtg  ttcagctct  720
aggatatta  caacaatga  aaaacttgg  cttgaagaa  tttacacaa  tagttagaa  780
ttgttacta  tgtaaagga  gagtcaact  gaaaattca  ggagttaat  aaatttgtt  840
acttggtcc  agcttttga  agataaatc  cttatgaat  cctggtcta  aatactttc  900
tacagctgt  taaaatact  gtcaaggag  actttttcc  tttacctca  gttgtaaac  960
taag  964



<210> 6804
<211> 224
<212> PRT
<213> Homo sapiens
<308> Q00688
<400> 6804

Met Ala Ala Ala Val Pro Gln Arg Ala Trp Thr Val Glu Gln Leu Arg 
  1               5                  10                  15
Ser Glu Gln Leu Pro Lys Lys Asp Ile Ile Lys Phe Leu Gln Glu His 
             20                  25                  30
Gly Ser Asp Ser Phe Leu Ala Glu His Lys Leu Leu Gly Asn Ile Lys 
         35                  40                  45
Asn Val Ala Lys Thr Ala Asn Lys Asp His Leu Val Thr Ala Tyr Asn 
     50                  55                  60
His Leu Phe Glu Thr Lys Arg Phe Lys Gly Thr Glu Ser Ile Ser Lys 
 65                  70                  75                  80
Val Ser Glu Gln Val Lys Asn Val Lys Leu Asn Glu Asp Lys Pro Lys 
                 85                  90                  95
Glu Thr Lys Ser Glu Glu Thr Leu Asp Glu Gly Pro Pro Lys Tyr Thr 
             100                105                110
Lys Ser Val Leu Lys Lys Gly Asp Lys Thr Asn Phe Pro Lys Lys Gly 
         115                120                125
Asp Val Val His Cys Trp Tyr Thr Gly Thr Leu Gln Asp Gly Thr Val 
     130                135                140
Phe Asp Thr Asn Ile Gln Thr Ser Ala Lys Lys Lys Lys Asn Ala Lys 
 145                150                155                160
Pro Leu Ser Phe Lys Val Gly Val Gly Lys Val Ile Arg Gly Trp Asp 
                 165                170                175
Glu Ala Leu Leu Thr Met Ser Lys Gly Glu Lys Ala Arg Leu Glu Ile 
             180                185                190
Glu Pro Glu Trp Ala Tyr Gly Lys Lys Gly Gln Pro Asp Ala Lys Ile 
         195                200                205
Pro Pro Asn Ala Lys Leu Thr Phe Glu Val Glu Leu Val Asp Ile Asp 
     210                215                220



<210> 6805
<211> 652
<212> DNA
<213> Rattus norvegicus
<308> AI103957
<400> 6805

agcatgcct  attttttcc  cctttatta  atgactgtt  caagattta  ttacagttg  60
aggttacac  ttagaaaga  taagtgcat  gaaggcata  gagtgctta  aaacccagc  120
cttgaaatg  aggcaggaa  gggacaagg  ttaaaaaga  gggagcgat  tgacccaca  180
tgggcagag  gggtggaca  ggccttcta  cttggctat  tggcctctg  acaagtagc  240
atggaggag  tttggctca  caggcagaa  tctccaggg  tcccagaag  acagggccc  300
gccagctag  gccagctcc  cctctacgt  cccacatac  ccacctatg  gtggtgtcg  360
ctccaaaag  tgacaggaa  agttcagaa  aaaaaagac  caaaagtaa  aaggctaag  420
gtagcagag  aatacagaa  tagtatata  acaggccat  gcccccaag  tggccgctg  480
tcattccag  gaccatctg  tgcgaagcg  agggcctca  tacacggag  tgttccgga  540
gccacagca  agcaccatg  tcagaatca  ctcgaagat  ataatgaca  ctaccacaa  600
ggctgcaat  ccaataagg  acagcttcc  agaaaagag  tcatcgatt  tc  652



<210> 6806
<211> 236
<212> PRT
<213> Rattus norvegicus
<308> Q62745
<400> 6806

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
  1               5                  10                  15
Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
             20                  25                  30
Leu Trp Leu Arg His Asp Pro Gln Thr Thr Thr Leu Leu Tyr Leu Glu 
         35                  40                  45
Leu Gly Asp Lys Pro Ala Pro Ser Thr Phe Tyr Val Gly Ile Tyr Ile 
     50                  55                  60
Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
 65                  70                  75                  80
Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                 85                  90                  95
Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
             100                105                110
Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
         115                120                125
Gln Ala Leu Gln Gln Ala Val Met Asp Asp Asp Ala Asn Asn Ala Lys 
     130                135                140
Ala Val Val Lys Thr Phe His Glu Thr Leu Asn Cys Cys Gly Ser Asn 
 145                150                155                160
Thr Leu Thr Thr Leu Thr Thr Ala Val Leu Arg Asn Ser Leu Cys Pro 
                 165                170                175
Ser Ser Ser Asn Ser Phe Thr Gln Leu Leu Lys Glu Asp Cys His Gln 
             180                185                190
Lys Ile Asp Glu Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
         195                200                205
Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
     210                215                220
Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
 225                230                235



<210> 6807
<211> 1332
<212> DNA
<213> Homo sapiens
<308> NM_004356
<400> 6807

ccggcccgc  ccccgcagg  cgcccgccg  ccgcgccgc  atgggagtg  agggctgca  60
caagtgcat  aagtacctg  tcttcgtct  caatttcgt  ttctggctg  ctggaggcg  120
gatcctggg  gtggccctg  ggctccgcc  tgacccgca  accaccaac  tcctgtatc  180
ggagctggg  gacaagccc  cgcccaaca  cttctatgt  ggcatctac  tcctcatcg  240
tgtgggcgc  gtcatgatg  tcgttggct  cctgggctg  tacggggcc  tccaggaat  300
ccagtgcct  ctggggacg  tcttcacct  cctggtcat  ctgtttgcc  gtgaggtgg  360
cgccggcat  tggggcttt  tcaacaagg  ccagatcgc  aaggatgtg  agcagttct  420
tgaccaggc  ctacagcag  ccgtggtgg  tgatgacgc  aacaacgcc  aggctgtgg  480
gaagacctt  cacgagacg  ttgactgct  tggctccag  acactgact  ctttgacca  540
ctcagtgct  aagaacaat  tgtgtccct  gggcagcaa  atcatcagc  acctcttca  600
ggaggactg  caccagaag  tcgatgacc  cttctccgg  aagctgtac  tcatcggca  660
tgctgccat  gtggtcgct  tgatcatga  cttcgagat  atcctgagc  tggtgctgt  720
ctgtggcat  cggaacagc  ccgtgtact  aggccccgc  gctctggcc  cagggacct  780
tgcagtgcc  cctaagtga  ccggacact  ccgaggggg  catcaccgc  tgtgtatat  840
acgtttccg  tattactct  ctacacgta  cctttttac  tttggggtt  tgtttttgt  900
ctgaacttt  ctgttacct  ttcagggct  acgtcacat  taggtggcg  gtatgagtg  960
agacgggcc  gggtcttgg  gactggagg  caggggtcc  tctgccctg  ggtcccagg  1020
tgctctgcc  gctcagcca  gcctctcct  ggagccact  gcccagaga  tcagcttgg  1080
caacttggg  ggctgtgtc  acccagccc  cccgtcctg  gggctgcac  gctcacctt  1140
ttccctcct  ccccggttc  agagccgag  ctgtgggca  tctctgcct  catgcacct  1200
tcctttcta  cacgtcgcc  tcaactgta  tcacaacat  ctgactccg  catttaata  1260
agaaggaac  tcaggcatg  taaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1320
aaaaaaaaa  aa  1332



<210> 6808
<211> 236
<212> PRT
<213> Homo sapiens
<308> P18582
<400> 6808

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
  1               5                  10                  15
Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
             20                  25                  30
Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
         35                  40                  45
Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
     50                  55                  60
Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
 65                  70                  75                  80
Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                 85                  90                  95
Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
             100                105                110
Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
         115                120                125
Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
     130                135                140
Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
 145                150                155                160
Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                 165                170                175
Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
             180                185                190
Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
         195                200                205
Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
     210                215                220
Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
 225                230                235



<210> 6809
<211> 652
<212> DNA
<213> Rattus norvegicus
<308> AI103957
<400> 6809

agcatgcct  attttttcc  cctttatta  atgactgtt  caagattta  ttacagttg  60
aggttacac  ttagaaaga  taagtgcat  gaaggcata  gagtgctta  aaacccagc  120
cttgaaatg  aggcaggaa  gggacaagg  ttaaaaaga  gggagcgat  tgacccaca  180
tgggcagag  gggtggaca  ggccttcta  cttggctat  tggcctctg  acaagtagc  240
atggaggag  tttggctca  caggcagaa  tctccaggg  tcccagaag  acagggccc  300
gccagctag  gccagctcc  cctctacgt  cccacatac  ccacctatg  gtggtgtcg  360
ctccaaaag  tgacaggaa  agttcagaa  aaaaaagac  caaaagtaa  aaggctaag  420
gtagcagag  aatacagaa  tagtatata  acaggccat  gcccccaag  tggccgctg  480
tcattccag  gaccatctg  tgcgaagcg  agggcctca  tacacggag  tgttccgga  540
gccacagca  agcaccatg  tcagaatca  ctcgaagat  ataatgaca  ctaccacaa  600
ggctgcaat  ccaataagg  acagcttcc  agaaaagag  tcatcgatt  tc  652



<210> 6810
<211> 236
<212> PRT
<213> Rattus norvegicus
<308> Q62745
<400> 6810

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
  1               5                  10                  15
Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
             20                  25                  30
Leu Trp Leu Arg His Asp Pro Gln Thr Thr Thr Leu Leu Tyr Leu Glu 
         35                  40                  45
Leu Gly Asp Lys Pro Ala Pro Ser Thr Phe Tyr Val Gly Ile Tyr Ile 
     50                  55                  60
Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
 65                  70                  75                  80
Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                 85                  90                  95
Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
             100                105                110
Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
         115                120                125
Gln Ala Leu Gln Gln Ala Val Met Asp Asp Asp Ala Asn Asn Ala Lys 
     130                135                140
Ala Val Val Lys Thr Phe His Glu Thr Leu Asn Cys Cys Gly Ser Asn 
 145                150                155                160
Thr Leu Thr Thr Leu Thr Thr Ala Val Leu Arg Asn Ser Leu Cys Pro 
                 165                170                175
Ser Ser Ser Asn Ser Phe Thr Gln Leu Leu Lys Glu Asp Cys His Gln 
             180                185                190
Lys Ile Asp Glu Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
         195                200                205
Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
     210                215                220
Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
 225                230                235



<210> 6811
<211> 1332
<212> DNA
<213> Homo sapiens
<308> NM_004356
<400> 6811

ccggcccgc  ccccgcagg  cgcccgccg  ccgcgccgc  atgggagtg  agggctgca  60
caagtgcat  aagtacctg  tcttcgtct  caatttcgt  ttctggctg  ctggaggcg  120
gatcctggg  gtggccctg  ggctccgcc  tgacccgca  accaccaac  tcctgtatc  180
ggagctggg  gacaagccc  cgcccaaca  cttctatgt  ggcatctac  tcctcatcg  240
tgtgggcgc  gtcatgatg  tcgttggct  cctgggctg  tacggggcc  tccaggaat  300
ccagtgcct  ctggggacg  tcttcacct  cctggtcat  ctgtttgcc  gtgaggtgg  360
cgccggcat  tggggcttt  tcaacaagg  ccagatcgc  aaggatgtg  agcagttct  420
tgaccaggc  ctacagcag  ccgtggtgg  tgatgacgc  aacaacgcc  aggctgtgg  480
gaagacctt  cacgagacg  ttgactgct  tggctccag  acactgact  ctttgacca  540
ctcagtgct  aagaacaat  tgtgtccct  gggcagcaa  atcatcagc  acctcttca  600
ggaggactg  caccagaag  tcgatgacc  cttctccgg  aagctgtac  tcatcggca  660
tgctgccat  gtggtcgct  tgatcatga  cttcgagat  atcctgagc  tggtgctgt  720
ctgtggcat  cggaacagc  ccgtgtact  aggccccgc  gctctggcc  cagggacct  780
tgcagtgcc  cctaagtga  ccggacact  ccgaggggg  catcaccgc  tgtgtatat  840
acgtttccg  tattactct  ctacacgta  cctttttac  tttggggtt  tgtttttgt  900
ctgaacttt  ctgttacct  ttcagggct  acgtcacat  taggtggcg  gtatgagtg  960
agacgggcc  gggtcttgg  gactggagg  caggggtcc  tctgccctg  ggtcccagg  1020
tgctctgcc  gctcagcca  gcctctcct  ggagccact  gcccagaga  tcagcttgg  1080
caacttggg  ggctgtgtc  acccagccc  cccgtcctg  gggctgcac  gctcacctt  1140
ttccctcct  ccccggttc  agagccgag  ctgtgggca  tctctgcct  catgcacct  1200
tcctttcta  cacgtcgcc  tcaactgta  tcacaacat  ctgactccg  catttaata  1260
agaaggaac  tcaggcatg  taaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1320
aaaaaaaaa  aa  1332



<210> 6812
<211> 236
<212> PRT
<213> Homo sapiens
<308> P18582
<400> 6812

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
  1               5                  10                  15
Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
             20                  25                  30
Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
         35                  40                  45
Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
     50                  55                  60
Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
 65                  70                  75                  80
Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                 85                  90                  95
Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
             100                105                110
Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
         115                120                125
Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
     130                135                140
Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
 145                150                155                160
Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                 165                170                175
Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
             180                185                190
Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
         195                200                205
Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
     210                215                220
Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
 225                230                235



<210> 6813
<211> 315
<212> DNA
<213> Rattus norvegicus
<308> AI104035
<400> 6813

tttccagtg  gtttttatt  gtagttgca  catgattca  ggtcccagg  tagggacca  60
catatactg  gggccccct  ttctaacgg  gagaagggc  aagagcaga  gaaaggtgg  120
cggagccag  tcagatctt  ccaggaaat  tgccttcgg  tatgcgggc  tcccaggct  180
agacccatg  gacggggca  agggacttg  acactcgcc  ggaccactc  caccctcgt  240
ccgaattct  ggcctcgag  gccaaattc  ctataggga  tcgtattaa  ttcggaatc  300
tgtcaaagc  gtttc  315



<210> 6814
<211> 86
<212> PRT
<213> Rattus norvegicus
<308> NP_079904
<400> 6814

Met Ala Glu Asp Ile Lys Thr Lys Ile Lys Asn Tyr Lys Thr Ala Pro 
  1               5                  10                  15
Phe Asp Ser Arg Phe Pro Asn Gln Asn Gln Thr Lys Asn Cys Trp Gln 
             20                  25                  30
Asn Tyr Leu Asp Phe His Arg Cys Glu Lys Ala Met Thr Ala Lys Gly 
         35                  40                  45
Gly Asp Val Ser Val Cys Glu Trp Tyr Arg Arg Val Tyr Lys Ser Leu 
     50                  55                  60
Cys Pro Val Ser Trp Val Ser Ala Trp Asp Asp Arg Ile Ala Glu Gly 
 65                  70                  75                  80
Thr Phe Pro Gly Lys Ile 
                 85



<210> 6815
<211> 1007
<212> DNA
<213> Homo sapiens
<308> AL528775
<400> 6815

agggtcaca  tgagctgca  gttgaatcc  gggtgcctt  aggattcag  accatggcg  60
aagacatgg  gaccaaaat  aagaactac  agaccgccc  ttttgacag  cgcttcccc  120
accagaacc  gactagaaa  tgctggcag  actacctgg  cttccaccg  tgtcagaag  180
aggtgacag  ggtggtctc  ttcctggaa  atctcttgt  tttgcaact  tggagctgc  240
gatgttcat  ttagtacgg  atatgccac  tctcagtac  aaggtgtca  actctccaa  300
tcacatagc  actaawact  gactatcag  agaaagtgc  cgtttggtg  cagccacag  360
taccatact  tctgattta  catcccttt  ttcacccgc  ggatgtatg  caatcctgc  420
cacaattct  ttcttaatt  cwagaatat  gawagacac  gcaataaag  ctgcagata  480
tcaggttcc  ccaccagtc  gtgcagctc  tcaagggat  aadagtatt  tgacacttt  540
aatggccaa  actgaggct  gcgttcaaa  acagtggac  gctctgatt  gtagcacgc  600
tgcttgcat  ctggaatat  ctcaaccag  ctctgtacc  acacctgat  aagtaagca  660
gctaacagc  attgcactc  tcctgtggt  tgctagtaa  gaaataata  gagtccagt  720
attacagaa  ggctgcatg  acagattta  aaatgcatt  aattcatgc  acccatggg  780
tcaagccaa  tgttaccag  ttctcctct  agtcttcca  cattccaat  gtgcccttt  840
aactcctta  attcattca  tagctccaa  agtggttga  aagctaaaa  ctgttgaaa  900
aaacagacc  gccagtaac  tagagcttt  agcggttca  gaaggaata  aagttcttg  960
aacactggt  gctcttggt  argacaaac  gagtcagct  cttgctc  1007



<210> 6816
<211> 488
<212> DNA
<213> Rattus norvegicus
<308> AI104389
<400> 6816

ttatccaga  gaatatgta  taaaactca  taaaaacca  caaatattg  aactgagat  60
aaaatttac  ctcaaacag  actataaaa  tttacacgt  aacaaaact  tcattaagg  120
cccagggct  agaagggca  gtggccttt  ctgaggagt  gtcactcct  gatgttctg  180
agcagcttc  gcaggtgtg  ctcaatgac  tgttgaaca  ttctgtagc  cagagctac  240
gccaagtcc  tagaattat  gccagagtc  gtttcaatt  ttgggtcag  tccattttc  300
aacagcatc  tcacgcact  cccgtggtt  ccgtggaca  cataaagca  aggggtgcc  360
ccgttccag  catactcat  tacgtcaac  ccacagtct  gcagcattt  gacaatgtc  420
gtgtagccc  tactgcagg  caacgacag  gcactttct  gaccttttc  taagagctg  480
ggatctgc  488



<210> 6817
<211> 498
<212> PRT
<213> Rattus norvegicus
<308> P04177
<400> 6817

Met Pro Thr Pro Ser Ala Pro Ser Pro Gln Pro Lys Gly Phe Arg Arg 
  1               5                  10                  15
Ala Val Ser Glu Gln Asp Ala Lys Gln Ala Glu Ala Val Thr Ser Pro 
             20                  25                  30
Arg Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu 
         35                  40                  45
Arg Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Ser Ser Glu 
     50                  55                  60
Pro Gly Asn Pro Leu Glu Ala Val Val Phe Glu Glu Arg Asp Gly Asn 
 65                  70                  75                  80
Ala Val Leu Asn Leu Leu Phe Ser Leu Arg Gly Thr Lys Pro Ser Ser 
                 85                  90                  95
Leu Ser Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His 
             100                105                110
His Leu Glu Thr Arg Pro Ala Gln Arg Pro Leu Ala Gly Ser Pro His 
         115                120                125
Leu Glu Tyr Phe Val Arg Phe Glu Val Pro Ser Gly Asp Leu Ala Ala 
     130                135                140
Leu Leu Ser Ser Val Arg Arg Val Ser Asp Asp Val Arg Ser Ala Arg 
 145                150                155                160
Glu Asp Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys 
                 165                170                175
Cys His His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His 
             180                185                190
Pro Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala 
         195                200                205
Glu Ile Ala Phe Gln Tyr Lys His Gly Glu Pro Ile Pro His Val Glu 
     210                215                220
Tyr Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Val Thr Leu 
 225                230                235                240
Lys Gly Leu Tyr Ala Thr His Ala Cys Arg Glu His Leu Glu Gly Phe 
                 245                250                255
Gln Leu Leu Glu Arg Tyr Cys Gly Tyr Arg Glu Asp Ser Ile Pro Gln 
             260                265                270
Leu Glu Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu 
         275                280                285
Arg Pro Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu 
     290                295                300
Ala Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser 
 305                310                315                320
Pro Met His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His 
                 325                330                335
Val Pro Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile 
             340                345                350
Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser 
         355                360                365
Thr Val Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly 
     370                375                380
Glu Leu Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu 
 385                390                395                400
Leu His Ser Leu Ser Glu Glu Pro Glu Val Arg Ala Phe Asp Pro Asp 
                 405                410                415
Thr Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Pro Val Tyr 
             420                425                430
Phe Val Ser Glu Ser Phe Asn Asp Ala Lys Asp Lys Leu Arg Asn Tyr 
         435                440                445
Ala Ser Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr 
     450                455                460
Leu Ala Ile Asp Val Leu Asp Ser Pro His Thr Ile Gln Arg Ser Leu 
 465                470                475                480
Glu Gly Val Gln Asp Glu Leu His Thr Leu Ala His Ala Leu Ser Ala 
                 485                490                495
Ile Ser 
             500



<210> 6818
<211> 1809
<212> DNA
<213> Homo sapiens
<308> AK022876
<400> 6818

agtgacgtc  cggccaaaa  aagcccggg  ttggaggcc  gtactgaag  tggcctcag  60
tgggaaggc  cgactcgct  tctgctgtc  tcggtggtc  cgagacctt  cactctcac  120
gggtcggcc  ccagcccct  tgcccggga  ccgctcgcc  cggatgagc  agagtttct  180
cctgggact  ttcgggcac  gctggccgg  ggcgacata  cggactttc  ttcctgcaa  240
agtctcccc  ccagcggga  acagcgggc  cctgtctcg  gacgctggg  cacctgtcg  300
ctattttta  atatccaga  tccaagaac  cactggata  tgctcttac  aaaccaaga  360
gaaatcatg  agaaatgtt  tagttattg  aactacagt  gaaatcatg  atacatcaa  420
aaatctgga  attggagcc  agcttatcg  ggaagagtg  cccagcact  atagcctaa  480
tggcatgcc  gacattaaa  tagaacatc  actggaccc  aattcagaa  aagggtcag  540
tcagggtgt  gccatggga  tgaaattca  attgcctaa  cgatttgat  tgaatgtgt  600
ttctcgatt  gtgaagtcc  taaatgaag  agatagtaa  aatattcaa  atcaggtta  660
ctctgacct  gaggtggca  ctgtcctat  taaagctga  tgcaatatc  atacatctc  720
ttctccggg  attcaagta  ggcatgtct  caccccctc  acaacaaag  atttctcac  780
cataaaaca  tcaaccact  taaccaaca  acacagagg  aatgaggtc  ctaccacac  840
tctgttagc  aattctttg  ctgttcacc  gttggctgc  cagggagag  tgctctatc  900
ggctactcg  atcgaacaa  aaaatgtta  caatcacac  gatgaagaa  gatttactc  960
tctgatgtg  gctgcagca  acgggcaaa  agctgtggt  gagttccta  ttcagaatg  1020
tgctgatcc  caactttta  gaaaaggtc  agaaagtgc  ctgtcgttg  cctgtagta  1080
aggctacac  gatattgtc  aaatgctgc  tgattgtgg  gttgatgta  atgaatatg  1140
ttggaatgg  ggaacacct  tgctttatg  tgtacatgg  aatcatgtg  aatgtgtaa  1200
gatgctctt  gaaagtggg  ctgatccaa  aattgaaac  gactctgga  ataattcta  1260
ggatctagc  gtagcccta  gctatagaa  tgttcaaca  gttattgag  cacatttgt  1320
gaagctgct  caaaatatc  aggagtaga  acagtcatc  gaaaatgtc  gcccttttg  1380
ttacttctt  gtccttata  atgatagtt  tgtttactt  taaattttt  cctcagttg  1440
aatatttac  ggtttttag  aggttttaa  aaatatttc  ctgagtaat  cactggttt  1500
taataaatg  aatactctt  ttataacta  gttttactg  atatttaaa  ttataaatt  1560
atgttttcg  ggcatgtaa  tttttatgg  acagatagt  atcatcagt  tttgtatca  1620
gtgctgtaa  ttgacattt  cagaaatta  tctacccta  tcatcttca  tcgtgtatt  1680
agtcattca  tttatatag  gtttgctat  aatccctag  aaaaaattg  tcttattgt  1740
gaataaaaa  gtgcacagt  tgattgttt  caaaatgat  ttataaata  ataaaatac  1800
tcttctgtc  1809



<210> 6819
<211> 314
<212> PRT
<213> Homo sapiens
<308> AK022876
<400> 6819

Met Asp Thr Ser Thr Asn Leu Asp Ile Gly Ala Gln Leu Ile Val Glu 
  1               5                  10                  15
Glu Cys Pro Ser Thr Tyr Ser Leu Thr Gly Met Pro Asp Ile Lys Ile 
             20                  25                  30
Glu His Pro Leu Asp Pro Asn Ser Glu Glu Gly Ser Ala Gln Gly Val 
         35                  40                  45
Ala Met Gly Met Lys Phe Ile Leu Pro Asn Arg Phe Asp Met Asn Val 
     50                  55                  60
Cys Ser Arg Phe Val Lys Ser Leu Asn Glu Glu Asp Ser Lys Asn Ile 
 65                  70                  75                  80
Gln Asp Gln Val Asn Ser Asp Leu Glu Val Ala Ser Val Leu Phe Lys 
                 85                  90                  95
Ala Glu Cys Asn Ile His Thr Ser Pro Ser Pro Gly Ile Gln Val Arg 
             100                105                110
His Val Tyr Thr Pro Ser Thr Thr Lys His Phe Ser Pro Ile Lys Gln 
         115                120                125
Ser Thr Thr Leu Thr Asn Lys His Arg Gly Asn Glu Val Ser Thr Thr 
     130                135                140
Pro Leu Leu Ala Asn Ser Leu Ser Val His Gln Leu Ala Ala Gln Gly 
 145                150                155                160
Glu Met Leu Tyr Leu Ala Thr Arg Ile Glu Gln Glu Asn Val Ile Asn 
                 165                170                175
His Thr Asp Glu Glu Gly Phe Thr Pro Leu Met Trp Ala Ala Ala His 
             180                185                190
Gly Gln Ile Ala Val Val Glu Phe Leu Leu Gln Asn Gly Ala Asp Pro 
         195                200                205
Gln Leu Leu Gly Lys Gly Arg Glu Ser Ala Leu Ser Leu Ala Cys Ser 
     210                215                220
Lys Gly Tyr Thr Asp Ile Val Lys Met Leu Leu Asp Cys Gly Val Asp 
 225                230                235                240
Val Asn Glu Tyr Asp Trp Asn Gly Gly Thr Pro Leu Leu Tyr Ala Val 
                 245                250                255
His Gly Asn His Val Lys Cys Val Lys Met Leu Leu Glu Ser Gly Ala 
             260                265                270
Asp Pro Thr Ile Glu Thr Asp Ser Gly Tyr Asn Ser Met Asp Leu Ala 
         275                280                285
Val Ala Leu Gly Tyr Arg Ser Val Gln Gln Val Ile Glu Ser His Leu 
     290                295                300
Leu Lys Leu Leu Gln Asn Ile Lys Glu Ter 
 305                310



<210> 6820
<211> 488
<212> DNA
<213> Rattus norvegicus
<308> AI104389
<400> 6820

ttatccaga  gaatatgta  taaaactca  taaaaacca  caaatattg  aactgagat  60
aaaatttac  ctcaaacag  actataaaa  tttacacgt  aacaaaact  tcattaagg  120
cccagggct  agaagggca  gtggccttt  ctgaggagt  gtcactcct  gatgttctg  180
agcagcttc  gcaggtgtg  ctcaatgac  tgttgaaca  ttctgtagc  cagagctac  240
gccaagtcc  tagaattat  gccagagtc  gtttcaatt  ttgggtcag  tccattttc  300
aacagcatc  tcacgcact  cccgtggtt  ccgtggaca  cataaagca  aggggtgcc  360
ccgttccag  catactcat  tacgtcaac  ccacagtct  gcagcattt  gacaatgtc  420
gtgtagccc  tactgcagg  caacgacag  gcactttct  gaccttttc  taagagctg  480
ggatctgc  488



<210> 6821
<211> 498
<212> PRT
<213> Rattus norvegicus
<308> P04177
<400> 6821

Met Pro Thr Pro Ser Ala Pro Ser Pro Gln Pro Lys Gly Phe Arg Arg 
  1               5                  10                  15
Ala Val Ser Glu Gln Asp Ala Lys Gln Ala Glu Ala Val Thr Ser Pro 
             20                  25                  30
Arg Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu 
         35                  40                  45
Arg Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Ser Ser Glu 
     50                  55                  60
Pro Gly Asn Pro Leu Glu Ala Val Val Phe Glu Glu Arg Asp Gly Asn 
 65                  70                  75                  80
Ala Val Leu Asn Leu Leu Phe Ser Leu Arg Gly Thr Lys Pro Ser Ser 
                 85                  90                  95
Leu Ser Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His 
             100                105                110
His Leu Glu Thr Arg Pro Ala Gln Arg Pro Leu Ala Gly Ser Pro His 
         115                120                125
Leu Glu Tyr Phe Val Arg Phe Glu Val Pro Ser Gly Asp Leu Ala Ala 
     130                135                140
Leu Leu Ser Ser Val Arg Arg Val Ser Asp Asp Val Arg Ser Ala Arg 
 145                150                155                160
Glu Asp Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys 
                 165                170                175
Cys His His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His 
             180                185                190
Pro Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala 
         195                200                205
Glu Ile Ala Phe Gln Tyr Lys His Gly Glu Pro Ile Pro His Val Glu 
     210                215                220
Tyr Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Val Thr Leu 
 225                230                235                240
Lys Gly Leu Tyr Ala Thr His Ala Cys Arg Glu His Leu Glu Gly Phe 
                 245                250                255
Gln Leu Leu Glu Arg Tyr Cys Gly Tyr Arg Glu Asp Ser Ile Pro Gln 
             260                265                270
Leu Glu Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu 
         275                280                285
Arg Pro Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu 
     290                295                300
Ala Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser 
 305                310                315                320
Pro Met His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His 
                 325                330                335
Val Pro Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile 
             340                345                350
Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser 
         355                360                365
Thr Val Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly 
     370                375                380
Glu Leu Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu 
 385                390                395                400
Leu His Ser Leu Ser Glu Glu Pro Glu Val Arg Ala Phe Asp Pro Asp 
                 405                410                415
Thr Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Pro Val Tyr 
             420                425                430
Phe Val Ser Glu Ser Phe Asn Asp Ala Lys Asp Lys Leu Arg Asn Tyr 
         435                440                445
Ala Ser Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr 
     450                455                460
Leu Ala Ile Asp Val Leu Asp Ser Pro His Thr Ile Gln Arg Ser Leu 
 465                470                475                480
Glu Gly Val Gln Asp Glu Leu His Thr Leu Ala His Ala Leu Ser Ala 
                 485                490                495
Ile Ser 
             500



<210> 6822
<211> 1809
<212> DNA
<213> Homo sapiens
<308> AK022876
<400> 6822

agtgacgtc  cggccaaaa  aagcccggg  ttggaggcc  gtactgaag  tggcctcag  60
tgggaaggc  cgactcgct  tctgctgtc  tcggtggtc  cgagacctt  cactctcac  120
gggtcggcc  ccagcccct  tgcccggga  ccgctcgcc  cggatgagc  agagtttct  180
cctgggact  ttcgggcac  gctggccgg  ggcgacata  cggactttc  ttcctgcaa  240
agtctcccc  ccagcggga  acagcgggc  cctgtctcg  gacgctggg  cacctgtcg  300
ctattttta  atatccaga  tccaagaac  cactggata  tgctcttac  aaaccaaga  360
gaaatcatg  agaaatgtt  tagttattg  aactacagt  gaaatcatg  atacatcaa  420
aaatctgga  attggagcc  agcttatcg  ggaagagtg  cccagcact  atagcctaa  480
tggcatgcc  gacattaaa  tagaacatc  actggaccc  aattcagaa  aagggtcag  540
tcagggtgt  gccatggga  tgaaattca  attgcctaa  cgatttgat  tgaatgtgt  600
ttctcgatt  gtgaagtcc  taaatgaag  agatagtaa  aatattcaa  atcaggtta  660
ctctgacct  gaggtggca  ctgtcctat  taaagctga  tgcaatatc  atacatctc  720
ttctccggg  attcaagta  ggcatgtct  caccccctc  acaacaaag  atttctcac  780
cataaaaca  tcaaccact  taaccaaca  acacagagg  aatgaggtc  ctaccacac  840
tctgttagc  aattctttg  ctgttcacc  gttggctgc  cagggagag  tgctctatc  900
ggctactcg  atcgaacaa  aaaatgtta  caatcacac  gatgaagaa  gatttactc  960
tctgatgtg  gctgcagca  acgggcaaa  agctgtggt  gagttccta  ttcagaatg  1020
tgctgatcc  caactttta  gaaaaggtc  agaaagtgc  ctgtcgttg  cctgtagta  1080
aggctacac  gatattgtc  aaatgctgc  tgattgtgg  gttgatgta  atgaatatg  1140
ttggaatgg  ggaacacct  tgctttatg  tgtacatgg  aatcatgtg  aatgtgtaa  1200
gatgctctt  gaaagtggg  ctgatccaa  aattgaaac  gactctgga  ataattcta  1260
ggatctagc  gtagcccta  gctatagaa  tgttcaaca  gttattgag  cacatttgt  1320
gaagctgct  caaaatatc  aggagtaga  acagtcatc  gaaaatgtc  gcccttttg  1380
ttacttctt  gtccttata  atgatagtt  tgtttactt  taaattttt  cctcagttg  1440
aatatttac  ggtttttag  aggttttaa  aaatatttc  ctgagtaat  cactggttt  1500
taataaatg  aatactctt  ttataacta  gttttactg  atatttaaa  ttataaatt  1560
atgttttcg  ggcatgtaa  tttttatgg  acagatagt  atcatcagt  tttgtatca  1620
gtgctgtaa  ttgacattt  cagaaatta  tctacccta  tcatcttca  tcgtgtatt  1680
agtcattca  tttatatag  gtttgctat  aatccctag  aaaaaattg  tcttattgt  1740
gaataaaaa  gtgcacagt  tgattgttt  caaaatgat  ttataaata  ataaaatac  1800
tcttctgtc  1809



<210> 6823
<211> 314
<212> PRT
<213> Homo sapiens
<308> AK022876
<400> 6823

Met Asp Thr Ser Thr Asn Leu Asp Ile Gly Ala Gln Leu Ile Val Glu 
  1               5                  10                  15
Glu Cys Pro Ser Thr Tyr Ser Leu Thr Gly Met Pro Asp Ile Lys Ile 
             20                  25                  30
Glu His Pro Leu Asp Pro Asn Ser Glu Glu Gly Ser Ala Gln Gly Val 
         35                  40                  45
Ala Met Gly Met Lys Phe Ile Leu Pro Asn Arg Phe Asp Met Asn Val 
     50                  55                  60
Cys Ser Arg Phe Val Lys Ser Leu Asn Glu Glu Asp Ser Lys Asn Ile 
 65                  70                  75                  80
Gln Asp Gln Val Asn Ser Asp Leu Glu Val Ala Ser Val Leu Phe Lys 
                 85                  90                  95
Ala Glu Cys Asn Ile His Thr Ser Pro Ser Pro Gly Ile Gln Val Arg 
             100                105                110
His Val Tyr Thr Pro Ser Thr Thr Lys His Phe Ser Pro Ile Lys Gln 
         115                120                125
Ser Thr Thr Leu Thr Asn Lys His Arg Gly Asn Glu Val Ser Thr Thr 
     130                135                140
Pro Leu Leu Ala Asn Ser Leu Ser Val His Gln Leu Ala Ala Gln Gly 
 145                150                155                160
Glu Met Leu Tyr Leu Ala Thr Arg Ile Glu Gln Glu Asn Val Ile Asn 
                 165                170                175
His Thr Asp Glu Glu Gly Phe Thr Pro Leu Met Trp Ala Ala Ala His 
             180                185                190
Gly Gln Ile Ala Val Val Glu Phe Leu Leu Gln Asn Gly Ala Asp Pro 
         195                200                205
Gln Leu Leu Gly Lys Gly Arg Glu Ser Ala Leu Ser Leu Ala Cys Ser 
     210                215                220
Lys Gly Tyr Thr Asp Ile Val Lys Met Leu Leu Asp Cys Gly Val Asp 
 225                230                235                240
Val Asn Glu Tyr Asp Trp Asn Gly Gly Thr Pro Leu Leu Tyr Ala Val 
                 245                250                255
His Gly Asn His Val Lys Cys Val Lys Met Leu Leu Glu Ser Gly Ala 
             260                265                270
Asp Pro Thr Ile Glu Thr Asp Ser Gly Tyr Asn Ser Met Asp Leu Ala 
         275                280                285
Val Ala Leu Gly Tyr Arg Ser Val Gln Gln Val Ile Glu Ser His Leu 
     290                295                300
Leu Lys Leu Leu Gln Asn Ile Lys Glu Ter 
 305                310



<210> 6824
<211> 585
<212> DNA
<213> Rattus norvegicus
<308> AI104513
<400> 6824

cccgaggcc  tctgcaccc  gtctcggct  ccagccccg  tgccgctgt  tgttccatt  60
gctgctatt  tcatgggtc  catgagaca  atgaggagt  tgatgctcg  tgggtgaca  120
acttcaaca  gccagacat  gatgcctgg  agttgcgta  agggatgaa  acacttgtt  180
gctatgatc  ggttcctga  cccaaaatc  ttgatgctg  tttgagggc  tgtagacgg  240
taaatgatt  tgctagtgc  gttcgcatc  tggaggttg  taaggacaa  gcaggacct  300
ataaggaaa  ctaccccta  gtcatccag  aacttagac  aactttaaa  gaattggga  360
tctccactc  agaggaact  ggccttgac  aagtgtaaa  tcccttcga  gggcttccc  420
aggacttaa  tgctattgc  acttgattg  aacagttgc  tggaaatgt  ttatttgaa  480
aaattttcc  ttgcgtatc  aaccatgta  cttggactt  aataaaggg  aatgagttt  540
acccgaaaa  aaaaataaa  aaaaaaaaa  agttgtcct  gtgcc  585



<210> 6825
<211> 146
<212> PRT
<213> Rattus norvegicus
<308> P11240
<400> 6825

Met Leu Ala Ala Ala Leu Arg Arg Cys Thr Ala Ala Ala Ala Ala Arg 
  1               5                  10                  15
Gly Leu Leu His Pro Val Ser Ala Pro Ser Pro Ala Ala Ala Val Cys 
             20                  25                  30
Ser Ile Arg Cys Tyr Ser His Gly Ser His Glu Thr Asp Glu Glu Phe 
         35                  40                  45
Asp Ala Arg Trp Val Thr Tyr Phe Asn Lys Pro Asp Ile Asp Ala Trp 
     50                  55                  60
Glu Leu Arg Lys Gly Met Asn Thr Leu Val Gly Tyr Asp Leu Val Pro 
 65                  70                  75                  80
Glu Pro Lys Ile Ile Asp Ala Ala Leu Arg Ala Cys Arg Arg Leu Asn 
                 85                  90                  95
Asp Phe Ala Ser Ala Val Arg Ile Leu Glu Val Val Lys Asp Lys Ala 
             100                105                110
Gly Pro His Lys Glu Ile Tyr Pro Tyr Val Ile Gln Glu Leu Arg Pro 
         115                120                125
Thr Leu Asn Glu Leu Gly Ile Ser Thr Pro Glu Glu Leu Gly Leu Asp 
     130                135                140
Lys Val 
 145



<210> 6826
<211> 647
<212> DNA
<213> Homo sapiens
<308> M22760
<400> 6826

gggcgccgc  atcgccgtc  tgctgggcg  cgctctccg  cgctgcgct  tggccgcaa  60
cacccgggc  gaccctcga  gcctcctgc  ctccgcccg  acccccggc  ccgccgtgg  120
tatccagtc  gttcgctgc  attcccatg  gtcacagga  acagatgag  agtttgatg  180
tcgctgggt  acatacttc  acaagccag  tatagatgc  tgggaattg  gtaaaggga  240
aaacacact  gttacctat  atatggttc  agagcccaa  atcattgat  ctgctttgc  300
ggcatgcag  cggttaaat  attttgcta  tctagttcg  atcctagag  ttgttaagg  360
caaagcagg  cctcataag  aaatctacc  ctatgtcat  caggaactt  gaccaactt  420
aaatgaact  ggaatctcc  ctccggagg  actgggcct  gacaaagtg  aaaccgcat  480
gatgggctt  cccaaggat  tattgacat  gctacttga  tgtgaacag  tacctggaa  540
tactgatga  aacatatta  cttattttg  acaagtttc  ctttattga  taccaagcc  600
tgtaatggt  acttggact  taataaaag  gaaatgagt  tgaactg  647



<210> 6827
<211> 150
<212> PRT
<213> Homo sapiens
<308> P20674
<400> 6827

Met Leu Gly Ala Ala Leu Arg Arg Cys Ala Val Ala Ala Thr Thr Arg 
  1               5                  10                  15
Ala Asp Pro Arg Gly Leu Leu His Ser Ala Arg Thr Pro Gly Pro Ala 
             20                  25                  30
Val Ala Ile Gln Ser Val Arg Cys Tyr Ser His Gly Ser Gln Glu Thr 
         35                  40                  45
Asp Glu Glu Phe Asp Ala Arg Trp Val Thr Tyr Phe Asn Lys Pro Asp 
     50                  55                  60
Ile Asp Ala Trp Glu Leu Arg Lys Gly Ile Asn Thr Leu Val Thr Tyr 
 65                  70                  75                  80
Asp Met Val Pro Glu Pro Lys Ile Ile Asp Ala Ala Leu Arg Ala Cys 
                 85                  90                  95
Arg Arg Leu Asn Asp Phe Ala Ser Leu Val Arg Ile Leu Glu Val Val 
             100                105                110
Lys Asp Lys Ala Gly Pro His Lys Glu Ile Tyr Pro Tyr Val Ile Gln 
         115                120                125
Glu Leu Arg Pro Thr Leu Asn Glu Leu Gly Ile Ser Thr Pro Glu Glu 
     130                135                140
Leu Gly Leu Asp Lys Val 
 145                150



<210> 6828
<211> 585
<212> DNA
<213> Rattus norvegicus
<308> AI104513
<400> 6828

cccgaggcc  tctgcaccc  gtctcggct  ccagccccg  tgccgctgt  tgttccatt  60
gctgctatt  tcatgggtc  catgagaca  atgaggagt  tgatgctcg  tgggtgaca  120
acttcaaca  gccagacat  gatgcctgg  agttgcgta  agggatgaa  acacttgtt  180
gctatgatc  ggttcctga  cccaaaatc  ttgatgctg  tttgagggc  tgtagacgg  240
taaatgatt  tgctagtgc  gttcgcatc  tggaggttg  taaggacaa  gcaggacct  300
ataaggaaa  ctaccccta  gtcatccag  aacttagac  aactttaaa  gaattggga  360
tctccactc  agaggaact  ggccttgac  aagtgtaaa  tcccttcga  gggcttccc  420
aggacttaa  tgctattgc  acttgattg  aacagttgc  tggaaatgt  ttatttgaa  480
aaattttcc  ttgcgtatc  aaccatgta  cttggactt  aataaaggg  aatgagttt  540
acccgaaaa  aaaaataaa  aaaaaaaaa  agttgtcct  gtgcc  585



<210> 6829
<211> 146
<212> PRT
<213> Rattus norvegicus
<308> P11240
<400> 6829

Met Leu Ala Ala Ala Leu Arg Arg Cys Thr Ala Ala Ala Ala Ala Arg 
  1               5                  10                  15
Gly Leu Leu His Pro Val Ser Ala Pro Ser Pro Ala Ala Ala Val Cys 
             20                  25                  30
Ser Ile Arg Cys Tyr Ser His Gly Ser His Glu Thr Asp Glu Glu Phe 
         35                  40                  45
Asp Ala Arg Trp Val Thr Tyr Phe Asn Lys Pro Asp Ile Asp Ala Trp 
     50                  55                  60
Glu Leu Arg Lys Gly Met Asn Thr Leu Val Gly Tyr Asp Leu Val Pro 
 65                  70                  75                  80
Glu Pro Lys Ile Ile Asp Ala Ala Leu Arg Ala Cys Arg Arg Leu Asn 
                 85                  90                  95
Asp Phe Ala Ser Ala Val Arg Ile Leu Glu Val Val Lys Asp Lys Ala 
             100                105                110
Gly Pro His Lys Glu Ile Tyr Pro Tyr Val Ile Gln Glu Leu Arg Pro 
         115                120                125
Thr Leu Asn Glu Leu Gly Ile Ser Thr Pro Glu Glu Leu Gly Leu Asp 
     130                135                140
Lys Val 
 145



<210> 6830
<211> 647
<212> DNA
<213> Homo sapiens
<308> M22760
<400> 6830

gggcgccgc  atcgccgtc  tgctgggcg  cgctctccg  cgctgcgct  tggccgcaa  60
cacccgggc  gaccctcga  gcctcctgc  ctccgcccg  acccccggc  ccgccgtgg  120
tatccagtc  gttcgctgc  attcccatg  gtcacagga  acagatgag  agtttgatg  180
tcgctgggt  acatacttc  acaagccag  tatagatgc  tgggaattg  gtaaaggga  240
aaacacact  gttacctat  atatggttc  agagcccaa  atcattgat  ctgctttgc  300
ggcatgcag  cggttaaat  attttgcta  tctagttcg  atcctagag  ttgttaagg  360
caaagcagg  cctcataag  aaatctacc  ctatgtcat  caggaactt  gaccaactt  420
aaatgaact  ggaatctcc  ctccggagg  actgggcct  gacaaagtg  aaaccgcat  480
gatgggctt  cccaaggat  tattgacat  gctacttga  tgtgaacag  tacctggaa  540
tactgatga  aacatatta  cttattttg  acaagtttc  ctttattga  taccaagcc  600
tgtaatggt  acttggact  taataaaag  gaaatgagt  tgaactg  647



<210> 6831
<211> 150
<212> PRT
<213> Homo sapiens
<308> P20674
<400> 6831

Met Leu Gly Ala Ala Leu Arg Arg Cys Ala Val Ala Ala Thr Thr Arg 
  1               5                  10                  15
Ala Asp Pro Arg Gly Leu Leu His Ser Ala Arg Thr Pro Gly Pro Ala 
             20                  25                  30
Val Ala Ile Gln Ser Val Arg Cys Tyr Ser His Gly Ser Gln Glu Thr 
         35                  40                  45
Asp Glu Glu Phe Asp Ala Arg Trp Val Thr Tyr Phe Asn Lys Pro Asp 
     50                  55                  60
Ile Asp Ala Trp Glu Leu Arg Lys Gly Ile Asn Thr Leu Val Thr Tyr 
 65                  70                  75                  80
Asp Met Val Pro Glu Pro Lys Ile Ile Asp Ala Ala Leu Arg Ala Cys 
                 85                  90                  95
Arg Arg Leu Asn Asp Phe Ala Ser Leu Val Arg Ile Leu Glu Val Val 
             100                105                110
Lys Asp Lys Ala Gly Pro His Lys Glu Ile Tyr Pro Tyr Val Ile Gln 
         115                120                125
Glu Leu Arg Pro Thr Leu Asn Glu Leu Gly Ile Ser Thr Pro Glu Glu 
     130                135                140
Leu Gly Leu Asp Lys Val 
 145                150



<210> 6832
<211> 532
<212> DNA
<213> Rattus norvegicus
<308> AI104520
<400> 6832

cagttcaag  tatttattt  agccatctc  tcttacgag  aaagggatg  aggagcaaa  60
taatggtca  catctgata  aggaaagat  agctgagca  ccaatgggc  ttcgtggtc  120
acacacaag  gtcagggtc  aaatcagtg  tgtggtccc  tgtcgcctg  gcgaagagc  180
aggttctct  tactcatct  catagccag  cggaagcgg  ttcatgtga  gattgtgga  240
gagggtatg  ttaccatct  cccagggga  gggcttagt  ctgatgcgg  gatgggggt  300
ggcgacgaa  tcgggtctc  cgtgctctt  gtgtcgcga  ttcaggaaa  cgttgagca  360
gctcactcc  accccgggc  gcgccacga  gtaggtgag  gccttccaa  tacgagctg  420
accctcctc  ccgtgggcg  cactcgaca  gggccgccc  acccgtggg  gggcccggc  480
cagcagccc  gagactcga  acgcactca  caccgccga  gcccctcgg  cc  532



<210> 6833
<211> 111
<212> PRT
<213> Rattus norvegicus
<308> P10818
<400> 6833

Met Ala Ser Ala Val Leu Ser Ala Ser Arg Val Ser Gly Leu Leu Gly 
  1               5                  10                  15
Arg Ala Leu Pro Arg Val Gly Arg Pro Met Ser Ser Gly Ala His Gly 
             20                  25                  30
Glu Glu Gly Ser Ala Arg Ile Trp Lys Ala Leu Thr Tyr Phe Val Ala 
         35                  40                  45
Leu Pro Gly Val Gly Val Ser Met Leu Asn Val Phe Leu Lys Ser Arg 
     50                  55                  60
His Glu Glu His Glu Arg Pro Glu Phe Val Ala Tyr Pro His Leu Arg 
 65                  70                  75                  80
Ile Arg Thr Lys Pro Phe Pro Trp Gly Asp Gly Asn His Thr Leu Phe 
                 85                  90                  95
His Asn Pro His Met Asn Pro Leu Pro Thr Gly Tyr Glu Asp Glu 
             100                105                110



<210> 6834
<211> 613
<212> DNA
<213> Rattus norvegicus
<308> AI104524
<400> 6834

aatttttat  tcaaaagct  ggatagctt  aatatccag  tcgtggcaa  atcaggaca  60
gtgtaaaat  ccttacaat  cattagatt  ccaaaaggt  ccaaaaagt  cagtaaaat  120
aacacttcc  ttactggaa  tgtatgaca  aaataatat  aaattaaaa  gtgaaaaag  180
tgacactgg  ttcctaaga  acagtttac  ctttacaac  agggtccac  ggtccaggc  240
gcagagcgg  agcaggaag  agaccctcc  atctagaac  gggtaacct  gtaataaaa  300
cagccccct  atgccgctc  gacctctga  acgccacac  ctgcctaca  caactagag  360
tctggaata  taaacagga  agtgatttc  gggggaaat  ttaaataag  tgcacatgg  420
acaggccat  aaagtttgc  aagttaaat  tggtacata  ttgtgttca  tccgcgtcc  480
aacaaagcg  gtgcggtcg  cactcggcc  ctcctgctg  ctctcagta  ggcttgtag  540
tattctgat  accaccacg  cgctggctc  tcccgtaat  tgtactacc  tgactgtag  600
cgtagccgg  gcc  613



<210> 6835
<211> 331
<212> PRT
<213> Rattus norvegicus
<308> NP_112620
<400> 6835

Met Ser Asp Ala Ala Glu Glu Gln Pro Met Glu Thr Thr Gly Ala Thr 
  1               5                  10                  15
Glu Asn Gly His Glu Ala Ala Pro Glu Gly Glu Ala Pro Val Glu Pro 
             20                  25                  30
Ser Pro Gly Ser Gly Pro Ala Thr Pro Ala Gly Ser Val Gly Gly Thr 
         35                  40                  45
Thr Ala Ala Pro Ser Gly Asn Gln Asn Gly Ala Glu Gly Asp Gln Ile 
     50                  55                  60
Asn Ala Ser Lys Asn Glu Glu Asp Ala Gly Lys Met Phe Val Gly Gly 
 65                  70                  75                  80
Leu Ser Trp Asp Thr Ser Lys Lys Asp Leu Lys Asp Tyr Phe Thr Lys 
                 85                  90                  95
Phe Gly Glu Val Val Asp Cys Thr Ile Lys Met Asp Pro Asn Thr Gly 
             100                105                110
Arg Ser Arg Gly Phe Gly Phe Ile Leu Phe Lys Asp Ser Ser Ser Val 
         115                120                125
Glu Lys Val Leu Asp Gln Lys Glu His Arg Leu Asp Gly Arg Val Ile 
     130                135                140
Asp Pro Lys Lys Ala Met Ala Met Lys Lys Asp Pro Val Lys Lys Ile 
 145                150                155                160
Phe Val Gly Gly Leu Asn Pro Glu Ala Thr Glu Glu Lys Ile Arg Glu 
                 165                170                175
Tyr Phe Gly Gln Phe Gly Glu Ile Glu Ala Ile Glu Leu Pro Ile Asp 
             180                185                190
Pro Lys Leu Asn Lys Arg Arg Gly Phe Val Phe Ile Thr Phe Lys Glu 
         195                200                205
Glu Asp Pro Val Lys Lys Val Leu Glu Lys Lys Phe His Thr Val Ser 
     210                215                220
Gly Ser Lys Cys Glu Ile Lys Val Ala Gln Pro Lys Glu Val Tyr Gln 
 225                230                235                240
Gln Gln Gln Tyr Gly Ser Gly Gly Arg Gly Asn Arg Asn Arg Gly Asn 
                 245                250                255
Arg Gly Ser Gly Gly Gly Gln Ser Gln Ser Trp Asn Gln Gly Tyr Gly 
             260                265                270
Asn Tyr Trp Asn Gln Gly Tyr Gly Tyr Gln Gln Gly Tyr Gly Pro Gly 
         275                280                285
Tyr Gly Gly Tyr Asp Tyr Ser Pro Tyr Gly Tyr Tyr Gly Tyr Gly Pro 
     290                295                300
Gly Tyr Asp Tyr Ser Gln Gly Ser Thr Asn Tyr Gly Lys Ser Gln Arg 
 305                310                315                320
Arg Gly Gly His Gln Asn Asn Tyr Lys Pro Tyr 
                 325                330



<210> 6836
<211> 263
<212> DNA
<213> Homo sapiens
<308> BF000687
<400> 6836

aatatccca  ctcaggcca  caacgaaca  ttttcccgc  tactcctag  tcttgctgg  60
gttgatctg  tcgccctcg  cgccgctct  attcccgat  gggggcatt  tttttctta  120
agctaaaat  aacacccag  caccaacta  agccctgcc  tgcccctcc  cccactggc  180
tgctcatct  cccgcactg  aaacctggc  gcctttagc  tccctccct  agcgtagtg  240
cccaaggtc  cctagcctg  ttt  263



<210> 6837
<211> 282
<212> PRT
<213> Homo sapiens
<308> Q9Y2D1
<400> 6837

Met Ser Leu Leu Ala Thr Leu Gly Leu Glu Leu Asp Arg Ala Leu Leu 
  1               5                  10                  15
Pro Ala Ser Gly Leu Gly Trp Leu Val Asp Tyr Gly Lys Leu Pro Pro 
             20                  25                  30
Ala Pro Ala Pro Leu Ala Pro Tyr Glu Val Leu Gly Gly Ala Leu Glu 
         35                  40                  45
Gly Gly Leu Pro Val Gly Gly Glu Pro Leu Ala Gly Asp Gly Phe Ser 
     50                  55                  60
Asp Trp Met Thr Glu Arg Val Asp Phe Thr Ala Leu Leu Pro Leu Glu 
 65                  70                  75                  80
Pro Pro Leu Pro Pro Gly Thr Leu Pro Gln Pro Ser Pro Thr Pro Pro 
                 85                  90                  95
Asp Leu Glu Ala Met Ala Ser Leu Leu Lys Lys Glu Leu Glu Gln Met 
             100                105                110
Glu Asp Phe Phe Leu Asp Ala Pro Pro Leu Pro Pro Pro Ser Pro Pro 
         115                120                125
Pro Leu Pro Pro Pro Pro Leu Pro Pro Ala Pro Ser Leu Pro Leu Ser 
     130                135                140
Leu Pro Ser Phe Asp Leu Pro Gln Pro Pro Val Leu Asp Thr Leu Asp 
 145                150                155                160
Leu Leu Ala Ile Tyr Cys Arg Asn Glu Ala Gly Gln Glu Glu Val Gly 
                 165                170                175
Met Pro Pro Leu Pro Pro Pro Gln Gln Pro Pro Pro Pro Ser Pro Pro 
             180                185                190
Gln Pro Ser Arg Leu Ala Pro Tyr Pro His Pro Ala Thr Thr Arg Gly 
         195                200                205
Asp Arg Lys Gln Lys Lys Arg Asp Gln Asn Lys Ser Ala Ala Leu Arg 
     210                215                220
Tyr Arg Gln Arg Lys Arg Ala Glu Gly Glu Ala Leu Glu Gly Glu Cys 
 225                230                235                240
Gln Gly Leu Glu Ala Arg Asn Arg Glu Leu Lys Glu Arg Ala Glu Ser 
                 245                250                255
Val Glu Arg Glu Ile Gln Tyr Val Lys Asp Leu Leu Ile Glu Val Tyr 
             260                265                270
Lys Ala Arg Ser Gln Arg Thr Arg Ser Cys 
         275                280



<210> 6838
<211> 479
<212> DNA
<213> Rattus norvegicus
<308> AI104679
<400> 6838

gaagagcac  agtattttt  tttctttct  ttttttttc  tttttttcc  ttttttcgg  60
gctggggac  aaacccagg  ccttgcgct  gctaggcaa  cgctctacc  ctgagctaa  120
tccccaacc  cttttttat  tctttaaca  tgcaaaata  acacgttga  ttgactagg  180
catattcac  tgtaaattt  ttctcatat  cacaactct  gatagatca  aggaatgac  240
aagatcatc  caggaagca  actgtagta  ctccaaagt  tattccagt  catttcttc  300
tttatactc  aaaacatct  cgttgtgtt  gtggatgag  taaatccac  tgaaaatcg  360
ggtgcccaa  gtcagccca  ctttcaccc  gttaggttt  gcattgact  gctcccgga  420
atagaactt  gaccgtgtt  aagagcatc  cggcagcct  gcgggggcc  gcagccgga  479



<210> 6839
<211> 76
<212> PRT
<213> Rattus norvegicus
<308> NP_079799
<400> 6839

Met Ala Pro Ser Val Val Leu Arg Ser Phe Ser Arg Leu Leu Ala Pro 
  1               5                  10                  15
Ala Arg Leu Pro Ser Cys Ser Ser Thr Arg Ser Lys Phe Tyr Val Arg 
             20                  25                  30
Glu Pro Val Asn Ala Lys Pro Asn Trp Leu Ala Val Gly Leu Ser Val 
         35                  40                  45
Gly Ala Ser Val Phe Met Trp Ile Tyr Leu Ile Gln Thr His Asn Glu 
     50                  55                  60
Asp Val Leu Glu Tyr Lys Arg Arg Asn Gly Leu Glu 
 65                  70                  75



<210> 6840
<211> 479
<212> DNA
<213> Rattus norvegicus
<308> AI104679
<400> 6840

gaagagcac  agtattttt  tttctttct  ttttttttc  tttttttcc  ttttttcgg  60
gctggggac  aaacccagg  ccttgcgct  gctaggcaa  cgctctacc  ctgagctaa  120
tccccaacc  cttttttat  tctttaaca  tgcaaaata  acacgttga  ttgactagg  180
catattcac  tgtaaattt  ttctcatat  cacaactct  gatagatca  aggaatgac  240
aagatcatc  caggaagca  actgtagta  ctccaaagt  tattccagt  catttcttc  300
tttatactc  aaaacatct  cgttgtgtt  gtggatgag  taaatccac  tgaaaatcg  360
ggtgcccaa  gtcagccca  ctttcaccc  gttaggttt  gcattgact  gctcccgga  420
atagaactt  gaccgtgtt  aagagcatc  cggcagcct  gcgggggcc  gcagccgga  479



<210> 6841
<211> 76
<212> PRT
<213> Rattus norvegicus
<308> NP_079799
<400> 6841

Met Ala Pro Ser Val Val Leu Arg Ser Phe Ser Arg Leu Leu Ala Pro 
  1               5                  10                  15
Ala Arg Leu Pro Ser Cys Ser Ser Thr Arg Ser Lys Phe Tyr Val Arg 
             20                  25                  30
Glu Pro Val Asn Ala Lys Pro Asn Trp Leu Ala Val Gly Leu Ser Val 
         35                  40                  45
Gly Ala Ser Val Phe Met Trp Ile Tyr Leu Ile Gln Thr His Asn Glu 
     50                  55                  60
Asp Val Leu Glu Tyr Lys Arg Arg Asn Gly Leu Glu 
 65                  70                  75



<210> 6842
<211> 331
<212> DNA
<213> Rattus norvegicus
<308> AI104707
<400> 6842

cattctaaa  ctaactttt  gcatactgt  acaaatcag  tcttcctaa  tttaagata  60
gggctaccc  tctagaaga  tggtgttgg  ttgtgctct  acagtacat  tgatcgcaa  120
gccttgtga  agctgcctc  taaggaacc  tctgctcag  cagggtcgc  ggggatcat  180
gtaggctga  cagtttcca  actgggctg  cttttcctt  tggctcccc  gcaccatgt  240
ctcccattt  gaggtggaa  tgaggagaa  cttaaaagc  tgagctcgc  agcagccca  300
gtggagcag  gccatgggt  tacacctgg  c  331



<210> 6843
<211> 151
<212> PRT
<213> Rattus norvegicus
<308> P51638
<400> 6843

Met Met Thr Glu Glu His Thr Asp Leu Glu Ala Arg Ile Ile Lys Asp 
  1               5                  10                  15
Ile His Cys Lys Glu Ile Asp Leu Val Asn Arg Asp Pro Lys Asn Ile 
             20                  25                  30
Asn Glu Asp Ile Val Lys Val Asp Phe Glu Asp Val Ile Ala Glu Pro 
         35                  40                  45
Glu Gly Thr Tyr Ser Phe Asp Gly Val Trp Arg Val Ser Tyr Thr Thr 
     50                  55                  60
Phe Thr Val Ser Lys Tyr Trp Cys Tyr Arg Leu Leu Ser Thr Leu Leu 
 65                  70                  75                  80
Gly Val Pro Leu Ala Leu Leu Trp Gly Phe Leu Phe Ala Cys Ile Ser 
                 85                  90                  95
Phe Cys His Ile Trp Ala Val Val Pro Cys Ile Lys Ser Tyr Leu Ile 
             100                105                110
Glu Ile Gln Cys Ile Ser His Ile Tyr Ser Leu Cys Ile Arg Thr Phe 
         115                120                125
Cys Asn Pro Leu Phe Ala Ala Leu Gly Gln Val Cys Ser Asn Ile Lys 
     130                135                140
Val Val Leu Arg Arg Glu Gly 
 145                150



<210> 6844
<211> 1358
<212> DNA
<213> Homo sapiens
<308> AF043101
<400> 6844

atggcagaa  agcacacag  tctcgaggc  cagatcgtc  aggatatcc  ctgcaagga  60
attgacctg  tgaaccgag  ccccaagaa  attaacgag  acatagtca  ggtggattt  120
gaagacgtg  tcgcagagc  tgtgggcac  tacagcttt  acggcgtgt  gaaggtgag  180
tacaccacc  tcactgtct  caagtactg  tgctaccgt  tgttgtcca  gctgctggg  240
gtcccactg  ccctgctct  gggcttcct  ttcgcctgc  tctccttct  ccacatctg  300
gcggtggtg  catgcatta  gagctacct  atcgagatc  agtgcatca  ccacatcta  360
tcactctgc  tccgcacct  ctgcaaccc  ctcttcgcg  ccctgggcc  ggtctgcag  420
agcatcaag  tggtgctgc  gaaggaggt  taaagccag  tggggcaac  gcggtggca  480
ggcaggggg  ggtgggcca  actggtccc  gggggactt  ttcacaggg  ctgctggcg  540
gctctttct  tttagggac  gctccatac  ccatggatg  agcacacgg  gtagggaag  600
cagaaagaa  agacggccc  gccacagaa  cacaatggc  cttcgctct  ccccagccc  660
accatgatg  cccatgcct  ggcgtggga  gatcatttg  caagaggca  ctactgcaa  720
tctttgcgt  cacttgtac  gtaacaaca  aaaccagca  gcggttccc  cccggggcc  780
acctctcca  gcgcactca  gaaagtgac  agtgaccac  ggcgttagg  aggtggctc  840
agtaaaggg  tttggctgc  tttggggaa  gctgcattt  gttcgtgcc  gtaagattg  900
tttgtgtcc  gaccagctc  aaaatatac  tcactgccc  gaaaacaga  acagggaga  960
ttggttgtc  cttcacttg  ccaaatgta  gtgaagaac  gagtctttt  cttcttcgg  1020
ttctattgt  tgctggaac  gtacacgtt  cttggaaga  catgtttaa  tgactcctg  1080
tgcctgagc  caaaaatgg  caccaatgg  ggaaaatga  ccttgggct  gcaggggca  1140
tgaccttcc  gggtaccac  gagggaagg  cctgggttc  agcctcccg  aacctcccc  1200
ttggctaac  gagcccctg  aatgcccag  actgccatt  gacatgagg  taccttcgc  1260
ctcaggaga  gtgacgaag  aacaaggtc  aatttgtgc  tgtgtggac  cactatgga  1320
ataaaatgc  gtagaaaga  caaaaaaaa  aaaaaaaa  1358



<210> 6845
<211> 151
<212> PRT
<213> Homo sapiens
<308> P56539
<400> 6845

Met Met Ala Glu Glu His Thr Asp Leu Glu Ala Gln Ile Val Lys Asp 
  1               5                  10                  15
Ile His Cys Lys Glu Ile Asp Leu Val Asn Arg Asp Pro Lys Asn Ile 
             20                  25                  30
Asn Glu Asp Ile Val Lys Val Asp Phe Glu Asp Val Ile Ala Glu Pro 
         35                  40                  45
Val Gly Thr Tyr Ser Phe Asp Gly Val Trp Lys Val Ser Tyr Thr Thr 
     50                  55                  60
Phe Thr Val Ser Lys Tyr Trp Cys Tyr Arg Leu Leu Ser Thr Leu Leu 
 65                  70                  75                  80
Gly Val Pro Leu Ala Leu Leu Trp Gly Phe Leu Phe Ala Cys Ile Ser 
                 85                  90                  95
Phe Cys His Ile Trp Ala Val Val Pro Cys Ile Lys Ser Tyr Leu Ile 
             100                105                110
Glu Ile Gln Cys Ile Ser His Ile Tyr Ser Leu Cys Ile Arg Thr Phe 
         115                120                125
Cys Asn Pro Leu Phe Ala Ala Leu Gly Gln Val Cys Ser Ser Ile Lys 
     130                135                140
Val Val Leu Arg Lys Glu Val 
 145                150



<210> 6846
<211> 572
<212> DNA
<213> Rattus norvegicus
<308> AI105044
<400> 6846

cacagaata  tattgttta  taatcatac  aggtgaatc  tgtaattcc  gaattttaa  60
gtgactttc  gtatgttta  aagtatttt  acaatttct  taaaaagaa  aaaatcagg  120
ctagagata  agccagtac  tatctagca  gcatgaggc  cagagttca  tccctgcac  180
gcacagaat  aaaatggtt  atatgtagg  gggtcaaga  catcatggg  ggtggtggc  240
cccagcact  cagaggcag  gggaggtgg  taatgagtt  aaggtcaac  tggtctaca  300
agcaagggc  gcgcatgga  tacacagag  aaacctgtc  tgaaaaact  aaaaacaaa  360
aagactggc  aaaacccaa  ttccaagtt  gaatgtagg  ccaggacct  agccaagtg  420
catccttgc  tggagctcc  aaggacctg  gagccgcta  cttgcagat  agctctatt  480
acccaggtc  ttcaccaca  aagatcggc  tcctaccat  cagtaaaga  ctttagcac  540
cagaaatca  gctcacagc  aggcaagtc  cg  572



<210> 6847
<211> 22
<212> PRT
<213> Rattus norvegicus
<308> AAC13319
<400> 6847

Pro Pro Thr Tyr Glu Pro Phe Ser Phe Cys Ala Val Gln Gly Leu Asn 
  1               5                  10                  15
Ser Glu Pro His Ala Cys 
             20



<210> 6848
<211> 707
<212> DNA
<213> Rattus norvegicus
<308> AI105054
<400> 6848

aaaattaag  aatttattt  taaaataac  aaaatttat  aacagatct  tttattgtg  60
aaatggtct  ggtacatat  aggaacttt  tatactttg  ggacagcat  cagaactgt  120
aagataaaa  acaaactat  attttaaac  cattcttga  ttaggggaa  ggctataaa  180
tacgggctg  aatgaattc  gcatgaact  aaattctac  aacataaag  atgaaagag  240
acaaaaacg  cggagtcca  tcagcccac  cctaaattt  aaccttaca  tttcgagga  300
cgtttgttc  ttcttagag  ctagtcttc  tttgagaca  gttgatttt  tctccaagg  360
tcaaggcca  tccctgact  tttgcacga  ttcttatat  gccagtaac  gcagcatct  420
gtccctggt  aactggctt  tcaatgctg  catttgcaa  tgcatcctc  ccaaatata  480
agcgagcat  taggttggc  gccatgaag  cacagtagc  agaaagggc  ttctctgga  540
tcaggcact  catgttggt  gacttgagg  tgtgctgta  ataatcatt  aggtcagtc  600
cgttggtgt  aactgtcac  ttattttcc  attcaaatt  ggcccacat  tgacggaac  660
cagcatcag  gcaagttgc  agctggata  agtccatga  gtcaatg  707



<210> 6849
<211> 953
<212> PRT
<213> Rattus norvegicus
<308> P23514
<400> 6849

Met Thr Ala Ala Glu Asn Val Cys Tyr Thr Leu Ile Asn Val Pro Met 
  1               5                  10                  15
Asp Ser Glu Pro Pro Ser Glu Ile Ser Leu Lys Asn Asp Leu Glu Lys 
             20                  25                  30
Gly Asp Val Lys Ser Lys Thr Glu Ala Leu Lys Lys Val Ile Ile Met 
         35                  40                  45
Ile Leu Asn Gly Glu Lys Leu Pro Gly Leu Leu Met Thr Ile Ile Arg 
     50                  55                  60
Phe Val Leu Pro Leu Gln Asp His Thr Ile Lys Lys Leu Leu Leu Val 
 65                  70                  75                  80
Phe Trp Glu Ile Val Pro Lys Thr Thr Pro Asp Gly Arg Leu Leu His 
                 85                  90                  95
Glu Met Ile Leu Val Cys Asp Ala Tyr Arg Lys Asp Leu Gln His Pro 
             100                105                110
Asn Glu Phe Ile Arg Gly Ser Thr Leu Arg Phe Leu Cys Lys Leu Lys 
         115                120                125
Glu Ala Glu Leu Leu Glu Pro Leu Met Pro Ala Ile Arg Ala Cys Leu 
     130                135                140
Glu His Arg His Ser Tyr Val Arg Arg Asn Ala Val Leu Ala Ile Tyr 
 145                150                155                160
Thr Ile Tyr Arg Asn Phe Glu Asn Leu Ile Pro Asp Ala Pro Glu Leu 
                 165                170                175
Ile His Asp Phe Leu Val Asn Glu Lys Asp Ala Ser Cys Lys Arg Asn 
             180                185                190
Ala Phe Met Met Leu Ile His Ala Asp Gln Asp Arg Ala Leu Asp Tyr 
         195                200                205
Leu Ser Thr Cys Ile Asp Gln Val Gln Thr Phe Gly Asp Ile Leu Gln 
     210                215                220
Leu Val Ile Val Glu Leu Ile Tyr Lys Val Cys His Ala Asn Pro Ser 
 225                230                235                240
Glu Arg Ala Arg Phe Ile Arg Cys Ile Tyr Asn Leu Leu Gln Ser Ser 
                 245                250                255
Ser Pro Ala Val Lys Tyr Glu Ala Ala Gly Thr Leu Val Thr Leu Ser 
             260                265                270
Ser Ala Pro Thr Ala Ile Lys Ala Ala Ala Gln Cys Tyr Ile Asp Leu 
         275                280                285
Ile Ile Lys Glu Ser Asp Asn Asn Val Lys Leu Ile Val Leu Asp Arg 
     290                295                300
Leu Val Glu Leu Lys Glu His Pro Ala His Glu Arg Val Leu Gln Asp 
 305                310                315                320
Leu Val Met Asp Ile Leu Arg Val Leu Ser Thr Pro Asp Leu Glu Val 
                 325                330                335
Arg Lys Lys Thr Leu Gln Leu Ala Leu Asp Leu Val Ser Ser Arg Asn 
             340                345                350
Val Glu Glu Leu Val Ile Val Leu Lys Lys Glu Val Ile Lys Thr Asn 
         355                360                365
Asn Val Ser Glu His Glu Asp Thr Asp Lys Tyr Arg Gln Leu Leu Val 
     370                375                380
Arg Thr Leu His Ser Cys Ser Val Arg Phe Pro Asp Met Ala Ala Asn 
 385                390                395                400
Val Ile Pro Val Leu Met Glu Phe Leu Ser Asp Ser Asn Glu Ala Ala 
                 405                410                415
Ala Ala Asp Val Leu Glu Phe Val Arg Glu Ala Ile Gln Arg Phe Asp 
             420                425                430
Asn Leu Arg Met Leu Ile Val Glu Lys Met Leu Glu Val Phe His Ala 
         435                440                445
Ile Lys Ser Val Lys Ile Tyr Arg Gly Ala Leu Trp Ile Leu Gly Glu 
     450                455                460
Tyr Cys Ser Thr Lys Glu Asp Ile Gln Ser Val Met Thr Glu Val Arg 
 465                470                475                480
Arg Ser Leu Gly Glu Ile Pro Ile Val Glu Ser Glu Ile Lys Lys Glu 
                 485                490                495
Ala Gly Glu Leu Lys Pro Glu Glu Glu Ile Thr Val Gly Pro Val Gln 
             500                505                510
Lys Leu Val Thr Glu Met Gly Thr Tyr Ala Thr Gln Ser Ala Leu Ser 
         515                520                525
Ser Ser Arg Pro Thr Lys Lys Glu Glu Asp Arg Pro Pro Leu Arg Gly 
     530                535                540
Phe Leu Leu Asp Gly Asp Phe Phe Val Ala Ala Ser Leu Ala Thr Thr 
 545                550                555                560
Leu Thr Lys Ile Ala Leu Arg Tyr Val Ala Leu Val Gln Glu Lys Lys 
                 565                570                575
Lys Gln Asn Ser Phe Val Ala Glu Ala Met Leu Leu Met Ala Thr Ile 
             580                585                590
Leu His Leu Gly Lys Ser Ser Leu Pro Lys Lys Pro Ile Thr Asp Asp 
         595                600                605
Asp Val Asp Arg Ile Ser Leu Cys Leu Lys Val Leu Ser Glu Cys Ser 
     610                615                620
Pro Leu Met Asn Asp Ile Phe Asn Lys Glu Cys Arg Gln Ser Leu Ser 
 625                630                635                640
Gln Met Leu Ser Ala Lys Leu Glu Glu Glu Lys Leu Ser Gln Lys Lys 
                 645                650                655
Glu Ser Glu Lys Arg Asn Val Thr Val Gln Pro Asp Asp Pro Ile Ser 
             660                665                670
Phe Met Gln Leu Thr Ala Lys Asn Glu Met Asn Cys Lys Glu Asp Gln 
         675                680                685
Phe Gln Leu Ser Leu Leu Ala Ala Met Gly Asn Thr Gln Arg Lys Glu 
     690                695                700
Ala Ala Asp Pro Leu Ala Ser Lys Leu Asn Lys Val Thr Gln Leu Thr 
 705                710                715                720
Gly Phe Ser Asp Pro Val Tyr Ala Glu Ala Tyr Val His Val Asn Gln 
                 725                730                735
Tyr Asp Ile Val Leu Asp Val Leu Val Val Asn Gln Thr Ser Asp Thr 
             740                745                750
Leu Gln Asn Cys Thr Leu Glu Leu Ala Thr Leu Gly Asp Leu Lys Leu 
         755                760                765
Val Glu Lys Pro Ser Pro Leu Thr Leu Ala Pro His Asp Phe Ala Asn 
     770                775                780
Ile Lys Ala Asn Val Lys Val Ala Ser Thr Glu Asn Gly Ile Ile Phe 
 785                790                795                800
Gly Asn Ile Val Tyr Asp Val Ser Gly Ala Ala Ser Asp Arg Asn Cys 
                 805                810                815
Val Val Leu Ser Asp Ile His Ile Asp Ile Met Asp Tyr Ile Gln Pro 
             820                825                830
Ala Thr Cys Thr Asp Ala Glu Phe Arg Gln Met Trp Ala Glu Phe Glu 
         835                840                845
Trp Glu Asn Lys Val Thr Val Asn Thr Asn Val Thr Asp Leu Asn Asp 
     850                855                860
Tyr Leu Gln His Ile Leu Lys Ser Thr Asn Met Lys Cys Leu Thr Pro 
 865                870                875                880
Glu Lys Ala Leu Ser Gly Tyr Cys Gly Phe Met Ala Ala Asn Leu Tyr 
                 885                890                895
Ala Arg Ser Ile Phe Gly Glu Asp Ala Leu Ala Asn Val Ser Ile Glu 
             900                905                910
Lys Pro Val His Gln Gly Pro Asp Ala Ala Val Thr Gly His Ile Arg 
         915                920                925
Ile Arg Ala Lys Ser Gln Gly Met Ala Leu Ser Leu Gly Asp Lys Ile 
     930                935                940
Asn Leu Ser Gln Lys Lys Thr Ser Leu 
 945                950



<210> 6850
<211> 1637
<212> DNA
<213> Homo sapiens
<308> AK001203
<400> 6850

ctataactt  ttacagtca  ccagccctg  tgtaaaata  gaagctgct  ggacattag  60
gacactctc  agtgcacca  ctgcaatca  ggctgctgc  cagtgttac  ttgatttaa  120
tattaagga  agcgacaac  atgtaaaac  catagtttt  gatcgcttg  tagaattaa  180
agagcatcc  gctcatgaa  gagtactac  ggatctggt  atggatatc  taagagtat  240
gagcacacc  gacttagaa  tacgaaaga  aactctgca  ttagcactg  atcttgtct  300
ttctagaaa  gttgaaaag  tggttattg  cctgaagaa  gaagtgata  aaacaaata  360
tgtgtctga  catgaagat  ctgacaaat  cagacaact  ctagtgcga  cattgcatt  420
ctgttctgt  cgatttcca  atatggctg  aaatgttat  cctgtgtta  tggaatttc  480
cagtgacaa  aacgaagca  cagctgctg  tgtcttgga  tttgttcgt  aagccattc  540
gcgctttga  aacctgaga  tgcttattg  tgagaagat  cttgaagtc  ttcatgcta  600
taaatctgt  aagatttac  gaggagcat  atggatcct  ggagaatac  gtagtacca  660
ggaagacat  cagagtgtg  tgactgaga  ccgcaggtc  cttggagag  tcccaattg  720
agagtcaga  ataaagaaa  aagctggtg  attaaaacc  gaagaagaa  tacctgtag  780
gccagttca  aaattggtt  ctgaaatgg  tacctatgc  actcagagt  cccttagca  840
ttctagacc  accaagaaa  aggaagaca  acctccctt  agaggattc  ttctggatg  900
agatttctt  gttgctgcc  cccttgcca  aactctgac  aagattgca  tgcgctatg  960
agctttggt  caggagaag  aaaagcaaa  ttcttttgt  gctgaggct  tgttgctca  1020
ggctactat  ctgcatttg  gaaaatcct  tcttcctaa  aagccaatt  ctgatgatg  1080
tgtggatcg  atttccctg  gcctcaagg  cttgtctga  tgttcacct  taatgaatg  1140
cattttcaa  aaggaatgc  gacagtccc  ttctcacat  ttatctgct  aactagaag  1200
agagaaatt  tcccaaaag  aagaatctg  aaagaggaa  gtgacagta  agcctgatg  1260
ccccatttc  ttcatgcaa  taactgcta  gaatgaaat  aactgcaag  aagatcagt  1320
tcagctgag  ttactggca  caatgggta  cacacagag  aaagaggca  cagatcccc  1380
agcatctaa  cttaacaag  tcacccaat  gacaggttt  tcagatcct  tatatgcag  1440
agcttacgt  catgtcaac  aatatgata  tgtcctgga  gtacttgtt  tgaaccaaa  1500
cagtgatac  ttgcagaat  gcacattag  actagctac  ctaggggat  tgaaacttg  1560
ggaaaagcc  tctcctttg  ctcttgctc  tcatgactt  gcaaatatt  aagctaacg  1620
caaagtagc  tcaacag  1637



<210> 6851
<211> 953
<212> PRT
<213> Homo sapiens
<308> P53618
<400> 6851

Met Thr Ala Ala Glu Asn Val Cys Tyr Thr Leu Ile Asn Val Pro Met 
  1               5                  10                  15
Asp Ser Glu Pro Pro Ser Glu Ile Ser Leu Lys Asn Asp Leu Glu Lys 
             20                  25                  30
Gly Asp Val Lys Ser Lys Thr Glu Ala Leu Lys Lys Val Ile Ile Met 
         35                  40                  45
Ile Leu Asn Gly Glu Lys Leu Pro Gly Leu Leu Met Thr Ile Ile Arg 
     50                  55                  60
Phe Val Leu Pro Leu Gln Asp His Thr Ile Lys Lys Leu Leu Leu Val 
 65                  70                  75                  80
Phe Trp Glu Ile Val Pro Lys Thr Thr Pro Asp Gly Arg Leu Leu His 
                 85                  90                  95
Glu Met Ile Leu Val Cys Asp Ala Tyr Arg Lys Asp Leu Gln His Pro 
             100                105                110
Asn Glu Phe Ile Arg Gly Ser Thr Leu Arg Phe Leu Cys Lys Leu Lys 
         115                120                125
Glu Ala Glu Leu Leu Glu Pro Leu Met Pro Ala Ile Arg Ala Cys Leu 
     130                135                140
Glu His Arg His Ser Tyr Val Arg Arg Asn Ala Val Leu Ala Ile Tyr 
 145                150                155                160
Thr Ile Tyr Arg Asn Phe Glu His Leu Ile Pro Asp Ala Pro Glu Leu 
                 165                170                175
Ile His Asp Phe Leu Val Asn Glu Lys Asp Ala Ser Cys Lys Arg Asn 
             180                185                190
Ala Phe Met Met Leu Ile His Ala Asp Gln Asp Arg Ala Leu Asp Tyr 
         195                200                205
Leu Ser Thr Cys Ile Asp Gln Val Gln Thr Phe Gly Asp Ile Leu Gln 
     210                215                220
Leu Val Ile Val Glu Leu Ile Tyr Lys Val Cys His Ala Asn Pro Ser 
 225                230                235                240
Glu Arg Ala Arg Phe Ile Arg Cys Ile Tyr Asn Leu Leu Gln Ser Ser 
                 245                250                255
Ser Pro Ala Val Lys Tyr Glu Ala Ala Gly Thr Leu Val Thr Leu Ser 
             260                265                270
Ser Ala Pro Thr Ala Ile Lys Ala Ala Ala Gln Cys Tyr Ile Asp Leu 
         275                280                285
Ile Ile Lys Glu Ser Asp Asn Asn Val Lys Leu Ile Val Leu Asp Arg 
     290                295                300
Leu Ile Glu Leu Lys Glu His Pro Ala His Glu Arg Val Leu Gln Asp 
 305                310                315                320
Leu Val Met Asp Ile Leu Arg Val Leu Ser Thr Pro Asp Leu Glu Val 
                 325                330                335
Arg Lys Lys Thr Leu Gln Leu Ala Leu Asp Leu Val Ser Ser Arg Asn 
             340                345                350
Val Glu Glu Leu Val Ile Val Leu Lys Lys Glu Val Ile Lys Thr Asn 
         355                360                365
Asn Val Ser Glu His Glu Asp Thr Asp Lys Tyr Arg Gln Leu Leu Val 
     370                375                380
Arg Thr Leu His Ser Cys Ser Val Arg Phe Pro Asp Met Ala Ala Asn 
 385                390                395                400
Val Ile Pro Val Leu Met Glu Phe Leu Ser Asp Asn Asn Glu Ala Ala 
                 405                410                415
Ala Ala Asp Val Leu Glu Phe Val Arg Glu Ala Ile Gln Arg Phe Asp 
             420                425                430
Asn Leu Arg Met Leu Ile Val Glu Lys Met Leu Glu Val Phe His Ala 
         435                440                445
Ile Lys Ser Val Lys Ile Tyr Arg Gly Ala Leu Trp Ile Leu Gly Glu 
     450                455                460
Tyr Cys Ser Thr Lys Glu Asp Ile Gln Ser Val Met Thr Glu Ile Arg 
 465                470                475                480
Arg Ser Leu Gly Glu Ile Pro Ile Val Glu Ser Glu Ile Lys Lys Glu 
                 485                490                495
Ala Gly Glu Leu Lys Pro Glu Glu Glu Ile Thr Val Gly Pro Val Gln 
             500                505                510
Lys Leu Val Thr Glu Met Gly Thr Tyr Ala Thr Gln Ser Ala Leu Ser 
         515                520                525
Ser Ser Arg Pro Thr Lys Lys Glu Glu Asp Arg Pro Pro Leu Arg Gly 
     530                535                540
Phe Leu Leu Asp Gly Asp Phe Phe Val Ala Ala Ser Leu Ala Thr Thr 
 545                550                555                560
Leu Thr Lys Ile Ala Leu Arg Tyr Val Ala Leu Val Gln Glu Lys Lys 
                 565                570                575
Lys Gln Asn Ser Phe Val Ala Glu Ala Met Leu Leu Met Ala Thr Ile 
             580                585                590
Leu His Leu Gly Lys Ser Ser Leu Pro Lys Lys Pro Ile Thr Asp Asp 
         595                600                605
Asp Val Asp Arg Ile Ser Leu Cys Leu Lys Val Leu Ser Glu Cys Ser 
     610                615                620
Pro Leu Met Asn Asp Ile Phe Asn Lys Glu Cys Arg Gln Ser Leu Ser 
 625                630                635                640
His Met Leu Ser Ala Lys Leu Glu Glu Glu Lys Leu Ser Gln Lys Lys 
                 645                650                655
Glu Ser Glu Lys Arg Asn Val Thr Val Gln Pro Asp Asp Pro Ile Ser 
             660                665                670
Phe Met Gln Leu Thr Ala Lys Asn Glu Met Asn Cys Lys Glu Asp Gln 
         675                680                685
Phe Gln Leu Ser Leu Leu Ala Ala Met Gly Asn Thr Gln Arg Lys Glu 
     690                695                700
Ala Ala Asp Pro Leu Ala Ser Lys Leu Asn Lys Val Thr Gln Leu Thr 
 705                710                715                720
Gly Phe Ser Asp Pro Val Tyr Ala Glu Ala Tyr Val His Val Asn Gln 
                 725                730                735
Tyr Asp Ile Val Leu Asp Val Leu Val Val Asn Gln Thr Ser Asp Thr 
             740                745                750
Leu Gln Asn Cys Thr Leu Glu Leu Ala Thr Leu Gly Asp Leu Lys Leu 
         755                760                765
Val Glu Lys Pro Ser Pro Leu Thr Leu Ala Pro His Asp Phe Ala Asn 
     770                775                780
Ile Lys Ala Asn Val Lys Val Ala Ser Thr Glu Asn Gly Ile Ile Phe 
 785                790                795                800
Gly Asn Ile Val Tyr Asp Val Ser Gly Ala Ala Ser Asp Arg Asn Cys 
                 805                810                815
Val Val Leu Ser Asp Ile His Ile Glu Ile Met Asp Tyr Ile Gln Pro 
             820                825                830
Ala Thr Cys Thr Asp Ala Glu Phe Arg Gln Met Trp Ala Glu Leu Glu 
         835                840                845
Trp Glu Asn Lys Val Thr Val Asn Thr Asn Met Val Asp Leu Asn Asp 
     850                855                860
Tyr Leu Gln His Ile Leu Lys Ser Thr Asn Met Lys Cys Leu Thr Pro 
 865                870                875                880
Glu Lys Ala Leu Ser Gly Tyr Cys Gly Phe Met Ala Ala Asn Leu Tyr 
                 885                890                895
Ala Arg Ser Ile Phe Gly Glu Asp Ala Leu Ala Asn Val Ser Ser Glu 
             900                905                910
Lys Pro Leu His Gln Gly Pro Asp Ala Ala Val Thr Val His Ile Arg 
         915                920                925
Ile Arg Ala Lys Ser Gln Gly Met Ala Leu Ser Leu Gly Asp Lys Ile 
     930                935                940
Asn Leu Ser Gln Lys Glu Thr Ser Ile 
 945                950



<210> 6852
<211> 638
<212> DNA
<213> Rattus norvegicus
<308> AI105448
<400> 6852

gaatttata  agttgatat  acctttatt  tatttaatg  tacattagg  atcattgtt  60
cattctgta  gaggtaaaa  tgatacaac  gtgtgctta  atccatagt  acaatcaag  120
tcacaactg  aggctacaa  gtggtttgt  acatttatt  caattacat  tttactgtg  180
aagtgttgc  agaatttct  atggtgagg  gtaccccaa  atttgtgta  ctctggaaa  240
gggctcata  aaatttgtg  gtagggctc  cagaaatat  aggcaggac  gttccaaga  300
ccttcacca  gcctcagga  ttcctagtt  cttacaaat  ggtccctgt  atatgaccg  360
aatgaaaga  attccatga  cctccttcc  ggattccca  gcagaagtg  agtccaaga  420
gatttgtca  agtatacct  atctttgcg  agaactgtg  ctttgatga  ctccagggc  480
cattcctcc  tgggagcag  ttgactcaa  attatccca  aggtttctt  caaagctgt  540
tctgtgtct  tgaagccga  gacacagag  gtgatggac  cgttgacct  ggtcatcaa  600
tgttctttt  taatggtgg  aaagaaccc  tccagagc  638



<210> 6853
<211> 287
<212> PRT
<213> Rattus norvegicus
<308> P16232
<400> 6853

Met Lys Lys Tyr Leu Leu Pro Val Leu Val Leu Cys Leu Gly Tyr Tyr 
  1               5                  10                  15
Tyr Ser Thr Asn Glu Glu Phe Arg Pro Glu Met Leu Gln Gly Lys Lys 
             20                  25                  30
Val Ile Val Thr Gly Ala Ser Lys Gly Ile Gly Arg Glu Met Ala Tyr 
         35                  40                  45
His Leu Ser Lys Met Gly Ala His Val Val Leu Thr Ala Arg Ser Glu 
     50                  55                  60
Glu Gly Leu Gln Lys Val Val Ser Arg Cys Leu Glu Leu Gly Ala Ala 
 65                  70                  75                  80
Ser Ala His Tyr Ile Ala Gly Thr Met Glu Asp Met Ala Phe Ala Glu 
                 85                  90                  95
Arg Phe Val Val Glu Ala Gly Lys Leu Leu Gly Gly Leu Asp Met Leu 
             100                105                110
Ile Leu Asn His Ile Thr Gln Thr Thr Met Ser Leu Phe His Asp Asp 
         115                120                125
Ile His Ser Val Arg Arg Ser Met Glu Val Asn Phe Leu Ser Tyr Val 
     130                135                140
Val Leu Ser Thr Ala Ala Leu Pro Met Leu Lys Gln Ser Asn Gly Ser 
 145                150                155                160
Ile Ala Ile Ile Ser Ser Met Ala Gly Lys Met Thr Gln Pro Leu Ile 
                 165                170                175
Ala Ser Tyr Ser Ala Ser Lys Phe Ala Leu Asp Gly Phe Phe Ser Thr 
             180                185                190
Ile Arg Lys Glu His Leu Met Thr Lys Val Asn Val Ser Ile Thr Leu 
         195                200                205
Cys Val Leu Gly Phe Ile Asp Thr Glu Thr Ala Leu Lys Glu Thr Ser 
     210                215                220
Gly Ile Ile Leu Ser Gln Ala Ala Pro Lys Gln Glu Cys Ala Leu Glu 
 225                230                235                240
Ile Lys Gly Thr Val Leu Arg Lys Asp Glu Val Tyr Tyr Asp Lys Ser 
                 245                250                255
Ser Trp Thr Pro Leu Leu Leu Gly Asn Pro Gly Arg Arg Ile Met Glu 
             260                265                270
Phe Leu Ser Leu Arg Ser Tyr Asn Arg Asp Leu Phe Val Ser Asn 
         275                280                285



<210> 6854
<211> 1375
<212> DNA
<213> Homo sapiens
<308> NM_005525
<400> 6854

attcagagg  tgctgcctg  ttaggaggt  gtagaaagc  ctgtaggtt  tctctgtgt  60
tcctacagg  gtcttcagg  cagctccct  tcggatggc  tttatgaaa  aatatctcc  120
ccccattct  gggctcttc  tggcctact  ctactattc  gcaaacgag  aattcagac  180
agagatgct  caaggaaag  aagtgattg  cacaggggc  agcaaaggg  tcggaagag  240
gatggctta  catctggcg  agatgggag  ccatgtggt  gtgacagcg  ggtcaaaag  300
aactctaca  aaggtggta  cccactgcc  ggagcttgg  gcagcctca  cacactaca  360
tgctggcac  atggaagac  tgaccttcg  agagcaatt  gttgcccaa  caggaaagc  420
catgggagg  ctagacatg  tcattctca  ccacatcac  aacacttct  tgaatcttt  480
tcatgatga  attcaccat  tgcgcaaaa  catggaagt  aacttcctc  gttacgtgg  540
cctgactgt  gctgccttg  ccatgctga  gcagagcaa  ggaagcatt  ttgtcgtct  600
ctctctggc  gggaaagtg  cttatccaa  ggttgctgc  tattctgca  gcaagtttg  660
tttggatgg  ttcttctcc  ccatcagaa  ggaatattc  gtgtccagg  tcaatgtat  720
aatcactct  tgtgttctt  gcctcatag  cacagaaac  gccatgaag  cagtttctg  780
gatagtcca  atgcaagca  ctccaaagg  ggaatgtgc  ctggagatc  tcaaagggg  840
agctctgcg  caagaagaa  tgtattatg  cagctcact  tggaccact  ttctgatca  900
aaatccatg  aggaagatc  tggaatttc  ctactcaac  agctataat  tggacagat  960
cataaacaa  taggaactc  ctgagggct  ggcatgctg  gggattttg  gactgttct  1020
tctcatgtt  atctgagct  ttatctatg  agacatctt  ccagagtgt  cccagagac  1080
tgcaagtca  gggtcacac  tgacaaatg  aaggagttc  tctaacatt  gcaaaatgg  1140
aatgtaata  taatgaatg  catgcaccg  tgcagccag  agttgtaaa  ttgttagta  1200
acataggta  aattaccag  tagttatat  aaatttata  cttatatat  ataatatgt  1260
atgattaat  caatattaa  tataataaa  gtcacataa  ctttataaa  tcataactg  1320
tagctataa  ttgagctta  tcaggatgg  tctttaaac  ataaactgt  caatg  1375



<210> 6855
<211> 292
<212> PRT
<213> Homo sapiens
<308> P28845
<400> 6855

Met Ala Phe Met Lys Lys Tyr Leu Leu Pro Ile Leu Gly Leu Phe Met 
  1               5                  10                  15
Ala Tyr Tyr Tyr Tyr Ser Ala Asn Glu Glu Phe Arg Pro Glu Met Leu 
             20                  25                  30
Gln Gly Lys Lys Val Ile Val Thr Gly Ala Ser Lys Gly Ile Gly Arg 
         35                  40                  45
Glu Met Ala Tyr His Leu Ala Lys Met Gly Ala His Val Val Val Thr 
     50                  55                  60
Ala Arg Ser Lys Glu Thr Leu Gln Lys Val Val Ser His Cys Leu Glu 
 65                  70                  75                  80
Leu Gly Ala Ala Ser Ala His Tyr Ile Ala Gly Thr Met Glu Asp Met 
                 85                  90                  95
Thr Phe Ala Glu Gln Phe Val Ala Gln Ala Gly Lys Leu Met Gly Gly 
             100                105                110
Leu Asp Met Leu Ile Leu Asn His Ile Thr Asn Thr Ser Leu Asn Leu 
         115                120                125
Phe His Asp Asp Ile His His Val Arg Lys Ser Met Glu Val Asn Phe 
     130                135                140
Leu Ser Tyr Val Val Leu Thr Val Ala Ala Leu Pro Met Leu Lys Gln 
 145                150                155                160
Ser Asn Gly Ser Ile Val Val Val Ser Ser Leu Ala Gly Lys Val Ala 
                 165                170                175
Tyr Pro Met Val Ala Ala Tyr Ser Ala Ser Lys Phe Ala Leu Asp Gly 
             180                185                190
Phe Phe Ser Ser Ile Arg Lys Glu Tyr Ser Val Ser Arg Val Asn Val 
         195                200                205
Ser Ile Thr Leu Cys Val Leu Gly Leu Ile Asp Thr Glu Thr Ala Met 
     210                215                220
Lys Ala Val Ser Gly Ile Val His Met Gln Ala Ala Pro Lys Glu Glu 
 225                230                235                240
Cys Ala Leu Glu Ile Ile Lys Gly Gly Ala Leu Arg Gln Glu Glu Val 
                 245                250                255
Tyr Tyr Asp Ser Ser Leu Trp Thr Thr Leu Leu Ile Arg Asn Pro Cys 
             260                265                270
Arg Lys Ile Leu Glu Phe Leu Tyr Ser Thr Ser Tyr Asn Met Asp Arg 
         275                280                285
Phe Ile Asn Lys 
     290



<210> 6856
<211> 332
<212> DNA
<213> Rattus norvegicus
<308> AI113289
<400> 6856

ttttttttt  tttttttcc  aaaacaaac  aaccacana  aggggagga  tgaggtgag  60
gcaacaaga  tatttggca  ttcctctac  tctcctgaa  aggttaagg  cctgagatt  120
gactctgtt  ttgggacca  gggctcctt  aaagcccag  gcacagatg  ccctcctgg  180
gctggccct  ccagttcca  cacaggctt  taagctgtt  tttcttcta  accaggtta  240
acgccgcag  ccaaatcct  acctgngca  tggcagcgc  caccacgct  atgcctcac  300
gcagtctgt  agtgaaaac  tacccggta  ca  332



<210> 6857
<211> 432
<212> PRT
<213> Rattus norvegicus
<308> P20417
<400> 6857

Met Glu Met Glu Lys Glu Phe Glu Gln Ile Asp Lys Ala Gly Asn Trp 
  1               5                  10                  15
Ala Ala Ile Tyr Gln Asp Ile Arg His Glu Ala Ser Asp Phe Pro Cys 
             20                  25                  30
Arg Ile Ala Lys Leu Pro Lys Asn Lys Asn Arg Asn Arg Tyr Arg Asp 
         35                  40                  45
Val Ser Pro Phe Asp His Ser Arg Ile Lys Leu His Gln Glu Asp Asn 
     50                  55                  60
Asp Tyr Ile Asn Ala Ser Leu Ile Lys Met Glu Glu Ala Gln Arg Ser 
 65                  70                  75                  80
Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Gly His Phe Trp 
                 85                  90                  95
Glu Met Val Trp Glu Gln Lys Ser Arg Gly Val Val Met Leu Asn Arg 
             100                105                110
Ile Met Glu Lys Gly Ser Leu Lys Cys Ala Gln Tyr Trp Pro Gln Lys 
         115                120                125
Glu Glu Lys Glu Met Val Phe Asp Asp Thr Asn Leu Lys Leu Thr Leu 
     130                135                140
Ile Ser Glu Asp Val Lys Ser Tyr Tyr Thr Val Arg Gln Leu Glu Leu 
 145                150                155                160
Glu Asn Leu Ala Thr Gln Glu Ala Arg Glu Ile Leu His Phe His Tyr 
                 165                170                175
Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe Leu 
             180                185                190
Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Ser Pro Glu His 
         195                200                205
Gly Pro Ile Val Val His Cys Ser Ala Gly Ile Gly Arg Ser Gly Thr 
     210                215                220
Phe Cys Leu Ala Asp Thr Cys Leu Leu Leu Met Asp Lys Arg Lys Asp 
 225                230                235                240
Pro Ser Ser Val Asp Ile Lys Lys Val Leu Leu Glu Met Arg Arg Phe 
                 245                250                255
Arg Met Gly Leu Ile Gln Thr Ala Asp Gln Leu Arg Phe Ser Tyr Leu 
             260                265                270
Ala Val Ile Glu Gly Ala Lys Phe Ile Met Gly Asp Ser Ser Val Gln 
         275                280                285
Asp Gln Trp Lys Glu Leu Ser His Glu Asp Leu Glu Pro Pro Pro Glu 
     290                295                300
His Val Pro Pro Pro Pro Arg Pro Pro Lys Arg Thr Leu Glu Pro His 
 305                310                315                320
Asn Gly Lys Cys Lys Glu Leu Phe Ser Asn His Gln Trp Val Ser Glu 
                 325                330                335
Glu Ser Cys Glu Asp Glu Asp Ile Leu Ala Arg Glu Glu Ser Arg Ala 
             340                345                350
Pro Ser Ile Ala Val His Ser Met Ser Ser Met Ser Gln Asp Thr Glu 
         355                360                365
Val Arg Lys Arg Met Val Gly Gly Gly Leu Gln Ser Ala Gln Ala Ser 
     370                375                380
Val Pro Thr Glu Glu Glu Leu Ser Pro Thr Glu Glu Glu Gln Lys Ala 
 385                390                395                400
His Arg Pro Val His Trp Lys Pro Phe Leu Val Asn Val Cys Met Ala 
                 405                410                415
Thr Ala Leu Ala Thr Gly Ala Tyr Leu Cys Tyr Arg Val Cys Phe His 
             420                425                430



<210> 6858
<211> 524
<212> DNA
<213> Homo sapiens
<308> AI803199
<400> 6858

ccagaaata  caaaaagct  ctttttata  aggttaaaa  caacaatgt  ttgtaattc  60
atttttttc  aaaaacaaa  gaataaaaa  aaaaagaga  agagaaaca  acgtatttg  120
cattttctc  acttactcc  gaataggtt  aggccctga  attagactc  tatattctt  180
ggaccagag  gctccttaa  accccagtg  atcgatcct  aattctctt  ttagccctt  240
cacagttcc  gactttaaa  acctttgat  tgtttcttc  gagactggc  cagatgcac  300
acagaactg  atcctacca  cgggctagc  gccagtgct  tctgcacac  agcatctcg  360
cagcgcgtc  gtcagtgga  acataccct  tagcagagg  aagcgccgg  cgtgaggac  420
gtagccacg  acatgttga  caggaaggg  ttccagtaa  tcagtgcat  gtcctcgtc  480
ttctcgggc  gtgacggct  ccctttgct  gggaggcag  ctgg  524



<210> 6859
<211> 435
<212> PRT
<213> Homo sapiens
<308> NP_002818
<400> 6859

Met Glu Met Glu Lys Glu Phe Glu Gln Ile Asp Lys Ser Gly Ser Trp 
  1               5                  10                  15
Ala Ala Ile Tyr Gln Asp Ile Arg His Glu Ala Ser Asp Phe Pro Cys 
             20                  25                  30
Arg Val Ala Lys Leu Pro Lys Asn Lys Asn Arg Asn Arg Tyr Arg Asp 
         35                  40                  45
Val Ser Pro Phe Asp His Ser Arg Ile Lys Leu His Gln Glu Asp Asn 
     50                  55                  60
Asp Tyr Ile Asn Ala Ser Leu Ile Lys Met Glu Glu Ala Gln Arg Ser 
 65                  70                  75                  80
Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Gly His Phe Trp 
                 85                  90                  95
Glu Met Val Trp Glu Gln Lys Ser Arg Gly Val Val Met Leu Asn Arg 
             100                105                110
Val Met Glu Lys Gly Ser Leu Lys Cys Ala Gln Tyr Trp Pro Gln Lys 
         115                120                125
Glu Glu Lys Glu Met Ile Phe Glu Asp Thr Asn Leu Lys Leu Thr Leu 
     130                135                140
Ile Ser Glu Asp Ile Lys Ser Tyr Tyr Thr Val Arg Gln Leu Glu Leu 
 145                150                155                160
Glu Asn Leu Thr Thr Gln Glu Thr Arg Glu Ile Leu His Phe His Tyr 
                 165                170                175
Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe Leu 
             180                185                190
Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Ser Pro Glu His 
         195                200                205
Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly Arg Ser Gly Thr 
     210                215                220
Phe Cys Leu Ala Asp Thr Cys Leu Leu Leu Met Asp Lys Arg Lys Asp 
 225                230                235                240
Pro Ser Ser Val Asp Ile Lys Lys Val Leu Leu Glu Met Arg Lys Phe 
                 245                250                255
Arg Met Gly Leu Ile Gln Thr Ala Asp Gln Leu Arg Phe Ser Tyr Leu 
             260                265                270
Ala Val Ile Glu Gly Ala Lys Phe Ile Met Gly Asp Ser Ser Val Gln 
         275                280                285
Asp Gln Trp Lys Glu Leu Ser His Glu Asp Leu Glu Pro Pro Pro Glu 
     290                295                300
His Ile Pro Pro Pro Pro Arg Pro Pro Lys Arg Ile Leu Glu Pro His 
 305                310                315                320
Asn Gly Lys Cys Arg Glu Phe Phe Pro Asn His Gln Trp Val Lys Glu 
                 325                330                335
Glu Thr Gln Glu Asp Lys Asp Cys Pro Ile Lys Glu Glu Lys Gly Ser 
             340                345                350
Pro Leu Asn Ala Ala Pro Tyr Gly Ile Glu Ser Met Ser Gln Asp Thr 
         355                360                365
Glu Val Arg Ser Arg Val Val Gly Gly Ser Leu Arg Gly Ala Gln Ala 
     370                375                380
Ala Ser Pro Ala Lys Gly Glu Pro Ser Leu Pro Glu Lys Asp Glu Asp 
 385                390                395                400
His Ala Leu Ser Tyr Trp Lys Pro Phe Leu Val Asn Met Cys Val Ala 
                 405                410                415
Thr Val Leu Thr Ala Gly Ala Tyr Leu Cys Tyr Arg Phe Leu Phe Asn 
             420                425                430
Ser Asn Thr 
         435



<210> 6860
<211> 295
<212> DNA
<213> Rattus norvegicus
<308> AI136175
<400> 6860

cggccgcaa  ggtttttcc  tatccattt  gggtaagca  caggatagg  aagcacacg  60
gacaagcca  agataatat  actctatgt  tcctgtcaa  gaggaacag  aaatgttct  120
tatgtgttt  tccccaccg  cagcacagt  tttacaagc  tttaaaata  tagtctgtt  180
caatatgct  ttttatcac  gagcaaagt  actcaggga  acagacagc  ttggtattc  240
ttcctttaa  tcaacaaaa  cttctggtc  tcttgagaa  gggactaag  gagca  295



<210> 6861
<211> 211
<212> PRT
<213> Rattus norvegicus
<308> AAA42000
<400> 6861

Met Gln Thr Pro His Lys Glu His Leu Tyr Lys Leu Leu Val Ile Gly 
  1               5                  10                  15
Asp Leu Gly Val Gly Lys Thr Ser Ile Ile Lys Arg Tyr Val His Gln 
             20                  25                  30
Asn Phe Ser Ser His Tyr Arg Ala Thr Ile Gly Val Asp Phe Ala Leu 
         35                  40                  45
Lys Val Leu His Trp Asp Pro Glu Thr Val Val Arg Leu Gln Leu Trp 
     50                  55                  60
Asp Ile Ala Gly Gln Glu Arg Phe Gly Asn Met Thr Arg Val Tyr Tyr 
 65                  70                  75                  80
Arg Glu Ala Met Gly Ala Phe Ile Val Phe Asp Val Thr Arg Pro Ala 
                 85                  90                  95
Thr Phe Glu Ala Val Ala Lys Trp Lys Asn Asp Leu Asp Ser Lys Leu 
             100                105                110
Thr Leu Pro Asn Gly Lys Pro Val Ser Val Val Leu Leu Ala Asn Lys 
         115                120                125
Cys Asp Gln Gly Lys Asp Val Leu Val Asn Asn Gly Leu Lys Met Asp 
     130                135                140
Gln Phe Cys Lys Glu His Gly Phe Val Gly Trp Phe Glu Thr Ser Ala 
 145                150                155                160
Lys Glu Asn Ile Asn Ile Asp Glu Ala Ser Arg Cys Leu Val Lys His 
                 165                170                175
Ile Leu Ala Asn Glu Cys Asp Phe Ile Glu Ser Ile Glu Pro Asp Ile 
             180                185                190
Val Lys Pro His Leu Thr Ser Pro Lys Val Val Ser Cys Ser Gly Cys 
         195                200                205
Ala Lys Ser 
     210



<210> 6862
<211> 1412
<212> DNA
<213> Homo sapiens
<308> AF235022
<400> 6862

ggctgcgct  ccctggtca  gcacggcac  tctggccgg  cgccaggat  caggccccg  60
acaaggagc  cctgtacaa  ttgctggtg  ttggcgacc  gggcgtggg  aagaccagt  120
tcatcaagc  ctacgtgca  cagaacttc  cctcgcact  ccgggccac  atcggcgtg  180
acttcgcgc  caaggtgct  cactgggac  cggagactg  ggtgcgcct  cagctctgg  240
atatcgcag  tcaagaaag  tttggaaac  tgacgaggg  ctattaccg  gaagctatg  300
gtgcattta  tgtcttcga  gtcaccagg  cagccacat  tgaagcagt  gcaaagtgg  360
aaaatgatt  ggactccaa  ttaagtctc  ctaatggca  accggtttc  gtggttttg  420
tggccaaca  atgtgacca  gggaaggat  tgctcatga  caatggcct  aagatggac  480
agttctgca  ggagcacgg  ttcgtagga  ggtttgaaa  atcagcaaa  gaaaatata  540
acattgatg  agcctccag  tgcctggtg  aacacatac  tgcaaatga  tgtgaccta  600
tggagtcta  tgagccgga  gtcgtgaag  cccatctca  atcaaccaa  gttgccagc  660
gctctggct  tgccaaatc  tagtaggca  ctttgctgg  gtctggtag  aatgacctc  720
ttgttccac  aattgtgcc  ctattttta  cattttggg  aaacgtcag  atagatata  780
cacatgtgg  aagccaaag  tctatgcct  tgttttttc  atgagagag  aatagcaaa  840
gttctttct  tgctttcct  accatcatc  cagtgttta  aaacttttg  aaatattta  900
tctgttaca  acttctgtc  tgtagctga  caaaatcct  cagggccac  gtcggcact  960
ttatttgct  cttttaatc  gcaaaggcc  caagtctta  aataaaagg  gagaagaac  1020
aactagctg  caagtcaag  actggcttt  accttgccc  ggtgtcttt  tccagattt  1080
aatatattc  ctgatggcc  gacaggcct  ttaagtaga  gtgatattt  cttccaaga  1140
gacctccat  ctcggcaga  ctaagagtt  cctctgagt  agctctttg  aatcgtgaa  1200
acaggtgtg  tatattgtc  ttgtcctaa  tgtcacttg  catggcctg  atgttggct  1260
aactgaata  tgtatgaaa  gacatgcct  catatgtgc  tttctgtta  ctctctttg  1320
ctcaagctg  ggggctcct  tatacatgc  atacatgta  tatatatta  atatatttt  1380
gcaagtgaa  aataaaaca  taaaagata  aa  1412



<210> 6863
<211> 211
<212> PRT
<213> Homo sapiens
<308> P57729
<400> 6863

Met Gln Ala Pro His Lys Glu His Leu Tyr Lys Leu Leu Val Ile Gly 
  1               5                  10                  15
Asp Leu Gly Val Gly Lys Thr Ser Ile Ile Lys Arg Tyr Val His Gln 
             20                  25                  30
Asn Phe Ser Ser His Tyr Arg Ala Thr Ile Gly Val Asp Phe Ala Leu 
         35                  40                  45
Lys Val Leu His Trp Asp Pro Glu Thr Val Val Arg Leu Gln Leu Trp 
     50                  55                  60
Asp Ile Ala Gly Gln Glu Arg Phe Gly Asn Met Thr Arg Val Tyr Tyr 
 65                  70                  75                  80
Arg Glu Ala Met Gly Ala Phe Ile Val Phe Asp Val Thr Arg Pro Ala 
                 85                  90                  95
Thr Phe Glu Ala Val Ala Lys Trp Lys Asn Asp Leu Asp Ser Lys Leu 
             100                105                110
Ser Leu Pro Asn Gly Lys Pro Val Ser Val Val Leu Leu Ala Asn Lys 
         115                120                125
Cys Asp Gln Gly Lys Asp Val Leu Met Asn Asn Gly Leu Lys Met Asp 
     130                135                140
Gln Phe Cys Lys Glu His Gly Phe Val Gly Trp Phe Glu Thr Ser Ala 
 145                150                155                160
Lys Glu Asn Ile Asn Ile Asp Glu Ala Ser Arg Cys Leu Val Lys His 
                 165                170                175
Ile Leu Ala Asn Glu Cys Asp Leu Met Glu Ser Ile Glu Pro Asp Val 
             180                185                190
Val Lys Pro His Leu Thr Ser Thr Lys Val Ala Ser Cys Ser Gly Cys 
         195                200                205
Ala Lys Ser 
     210



<210> 6864
<211> 435
<212> DNA
<213> Rattus norvegicus
<308> AI136396
<400> 6864

ttttttttt  tttttgtat  ccaacccag  gctgatggc  ttgttttgt  tgacaggaa  60
ggacaaaga  accacaact  cacagtggc  aaggctcaa  tagcacgga  tgtgctatg  120
acccaaacg  agaaacctt  tctgacggg  gatttgggg  agccatggg  tcctctagt  180
agtggcagg  tctgaggtc  ccgcatctt  gcattcctc  aagcctggg  ccggcttct  240
cagaaagtg  gtggtggcc  ggatcacct  atcaggtcc  atgttgtac  cagggtgag  300
gggctgcag  acattttca  gcacaccca  gaccacatc  tgcagcatg  ctccacttc  360
aaaatgctg  gcaatggac  ggccgctca  gcagtagca  gtatggtag  agtcacgtg  420
cttgccagg  ttgtc  435



<210> 6865
<211> 437
<212> PRT
<213> Rattus norvegicus
<308> Q02293
<400> 6865

Met Ala Ser Ser Ser Ser Phe Thr Tyr Tyr Cys Pro Pro Ser Ser Ser 
  1               5                  10                  15
Pro Val Trp Ser Glu Pro Leu Tyr Ser Leu Arg Pro Glu His Ala Arg 
             20                  25                  30
Glu Arg Leu Gln Asp Asp Ser Val Glu Thr Val Thr Ser Ile Glu Gln 
         35                  40                  45
Ala Lys Val Glu Glu Lys Ile Gln Glu Val Phe Ser Ser Tyr Lys Phe 
     50                  55                  60
Asn His Leu Val Pro Arg Leu Val Leu Gln Arg Glu Lys His Phe His 
 65                  70                  75                  80
Tyr Leu Lys Arg Gly Leu Arg Gln Leu Thr Asp Ala Tyr Glu Cys Leu 
                 85                  90                  95
Asp Ala Ser Arg Pro Trp Leu Cys Tyr Trp Ile Leu His Ser Leu Glu 
             100                105                110
Leu Leu Asp Glu Pro Ile Pro Gln Ile Val Ala Thr Asp Val Cys Gln 
         115                120                125
Phe Leu Glu Leu Cys Gln Ser Pro Asp Gly Gly Phe Gly Gly Gly Pro 
     130                135                140
Gly Gln Tyr Pro His Leu Ala Pro Thr Tyr Ala Ala Val Asn Ala Leu 
 145                150                155                160
Cys Ile Ile Gly Thr Glu Glu Ala Tyr Asn Val Ile Asn Arg Glu Lys 
                 165                170                175
Leu Leu Gln Tyr Leu Tyr Ser Leu Lys Gln Pro Asp Gly Ser Phe Leu 
             180                185                190
Met His Val Gly Gly Glu Val Asp Val Arg Ser Ala Tyr Cys Ala Ala 
         195                200                205
Ser Val Ala Ser Leu Thr Asn Ile Ile Thr Pro Asp Leu Phe Glu Gly 
     210                215                220
Thr Ala Glu Trp Ile Ala Arg Cys Gln Asn Trp Glu Gly Gly Ile Gly 
 225                230                235                240
Gly Val Pro Gly Met Glu Ala His Gly Gly Tyr Thr Phe Cys Gly Leu 
                 245                250                255
Ala Ala Leu Val Ile Leu Lys Lys Glu Arg Ser Leu Asn Leu Lys Ser 
             260                265                270
Leu Leu Gln Trp Val Thr Ser Arg Gln Met Arg Phe Glu Gly Gly Phe 
         275                280                285
Gln Gly Arg Cys Asn Lys Leu Val Asp Gly Cys Tyr Ser Phe Trp Gln 
     290                295                300
Ala Gly Leu Leu Pro Leu Leu His Arg Ala Leu His Ala Gln Gly Asp 
 305                310                315                320
Pro Ala Leu Ser Met Ser His Trp Met Phe His Gln Gln Ala Leu Gln 
                 325                330                335
Glu Tyr Ile Leu Met Cys Cys Gln Cys Pro Ala Gly Gly Leu Leu Asp 
             340                345                350
Lys Pro Gly Lys Ser Arg Asp Phe Tyr His Thr Cys Tyr Cys Leu Ser 
         355                360                365
Gly Leu Ser Ile Ala Gln His Phe Gly Ser Gly Ala Met Leu His Asp 
     370                375                380
Val Val Met Gly Val Pro Glu Asn Val Leu Gln Pro Thr His Pro Val 
 385                390                395                400
Tyr Asn Ile Gly Pro Asp Lys Val Ile Gln Ala Thr Thr His Phe Leu 
                 405                410                415
Gln Lys Pro Val Pro Gly Phe Glu Glu Cys Glu Asp Ala Val Thr Ser 
             420                425                430
Asp Pro Ala Thr Asp 
         435



<210> 6866
<211> 2069
<212> DNA
<213> Homo sapiens
<308> AK024087
<400> 6866

tctaaatgt  acctggcca  tgtccctca  ctagtgctc  accttggaa  cccttttcc  60
ctgtgtctc  ttttaaaga  atttaataa  ttcttattg  ctgtttgga  tattcaaca  120
tttaggctg  gtgcggtgg  ccatgcctg  aatcccagt  ctttgggag  ccaaaagag  180
gtgggtcac  tgaggtcag  agttagaga  cagcctgac  aacatagtg  aaccatgtc  240
ctactaaaa  tacaagaat  agccaggca  ggtggtgca  gcctgtaat  ccagctact  300
gggaggctg  ggcaggaca  tcgcctcct  ggttcacgc  attctcctg  ctcagcctc  360
tgagtagct  ggactacag  cgcccacca  catgtccgg  taatttttt  gtattttta  420
tagagacag  gtttcaccg  gttggccgg  atggtctcg  tctcctgac  tcgtgatca  480
cccccctca  cctcccaaa  tgctgggat  acaggcata  gccatcgtg  ctggcccac  540
ataggaatt  atatactga  atatatata  gatttttag  tcagttctt  ttatgatac  600
gttacctta  atgcccact  agtgaaata  tatatggct  ttcacagtg  tggctatgc  660
gattatgta  tagaataga  aatttatgc  tatagtggt  taagtgaaa  acataagct  720
cacagttat  ataactagg  agaaaaacg  atagaacca  aaagactgg  agaaagaac  780
attagcttt  aggtgccat  taccaattg  tgggcatct  tttttttaa  aatgattta  840
tgtcaggca  cttttagcc  aggtatcaa  atataaaat  gaccaagga  ttagtgtac  900
tcctatatg  atatatatt  ttaatcgat  tctatgcag  tgtttctgc  cacctgtcc  960
tgatttgtc  ctccttccc  cttgataac  gtgtggccc  cagaattct  tgaccatag  1020
gattggact  cagagtgaa  aagtccagt  gcttgtcag  accttagta  tattaccag  1080
atacccagt  tttgctagg  tatcatatg  tgcaggagg  cagttacta  taatgtttc  1140
taggtaaat  ctttgagct  agagacaag  tagagaatt  cctttggag  tcaattaaa  1200
ttaggctta  aaaagtaga  gaaacagac  ttattaccc  ttaagagtt  tctgagcta  1260
tcagtctgg  taacaagtt  tagagatat  ctagaggga  tgtctcttg  agtccaggg  1320
agagttatg  accaagttg  gagcagcta  cgaggtcag  ctgggaagg  aagctaaac  1380
gctaggctg  ttcactgcc  gccagagat  tggttgagg  tcaccatcc  cgttaacag  1440
gtgcatttc  agaaagtga  agtgccact  tgaattgct  ctctttgac  catgtcaaa  1500
ttcaggaga  gggacatgc  gtgcgtagg  catggggaa  atagcagtt  taccaagaa  1560
gaatggaag  ggaagggga  caggaaacc  tgactattc  cccaggtga  aaagtggaa  1620
taggtcatt  atacttggc  ggatctgcc  ggcccttac  gaccctttg  ccttcaaca  1680
gtgaccctg  ccttagcat  agccactgg  tgttccatc  gcaggccct  caggagtac  1740
tcctgatgt  ctgccagtg  cctgcgggg  ggcttctgg  taaacctgg  aagtgagtg  1800
tttctctct  gggagggag  ggagagggg  ggagagagc  gaggggcgt  cacctcagg  1860
ctactcaga  ccagatctc  agagcagag  tgtcacctt  agcacctgc  tagcgctag  1920
ttgtatggg  aaaagcacc  agttgggag  accccttga  gccattgat  ctggcacct  1980
cagctgccc  tcttgtccc  cagcctgca  gcaaccccc  cccccagac  gggaaacag  2040
ttgctgggt  gataactct  ctttttttt  2069



<210> 6867
<211> 437
<212> PRT
<213> Homo sapiens
<308> NP_002019
<400> 6867

Met Ala Ser Pro Ser Ser Phe Thr Tyr Tyr Cys Pro Pro Ser Ser Ser 
  1               5                  10                  15
Pro Val Trp Ser Glu Pro Leu Tyr Ser Leu Arg Pro Glu His Ala Arg 
             20                  25                  30
Glu Arg Leu Gln Asp Asp Ser Val Glu Thr Val Thr Ser Ile Glu Gln 
         35                  40                  45
Ala Lys Val Glu Glu Lys Ile Gln Glu Val Phe Ser Ser Tyr Lys Phe 
     50                  55                  60
Asn His Leu Val Pro Arg Leu Val Leu Gln Arg Glu Lys His Phe His 
 65                  70                  75                  80
Tyr Leu Lys Arg Gly Leu Arg Gln Leu Thr Asp Ala Tyr Glu Cys Leu 
                 85                  90                  95
Asp Ala Ser Arg Pro Trp Leu Cys Tyr Trp Ile Leu His Ser Leu Glu 
             100                105                110
Leu Leu Asp Glu Pro Ile Pro Gln Ile Val Ala Thr Asp Val Cys Gln 
         115                120                125
Phe Leu Glu Leu Cys Gln Ser Pro Glu Gly Gly Phe Gly Gly Gly Pro 
     130                135                140
Gly Gln Tyr Pro His Leu Ala Pro Thr Tyr Ala Ala Val Asn Ala Leu 
 145                150                155                160
Cys Ile Ile Gly Thr Glu Glu Ala Tyr Asp Ile Ile Asn Arg Glu Lys 
                 165                170                175
Leu Leu Gln Tyr Leu Tyr Ser Leu Lys Gln Pro Asp Gly Ser Phe Leu 
             180                185                190
Met His Val Gly Gly Glu Val Asp Val Arg Ser Ala Tyr Cys Ala Ala 
         195                200                205
Ser Val Ala Ser Leu Thr Asn Ile Ile Thr Pro Asp Leu Phe Glu Gly 
     210                215                220
Thr Ala Glu Trp Ile Ala Arg Cys Gln Asn Trp Glu Gly Gly Ile Gly 
 225                230                235                240
Gly Val Pro Gly Met Glu Ala His Gly Gly Tyr Thr Phe Cys Gly Leu 
                 245                250                255
Ala Ala Leu Val Ile Leu Lys Arg Glu Arg Ser Leu Asn Leu Lys Ser 
             260                265                270
Leu Leu Gln Trp Val Thr Ser Arg Gln Met Arg Phe Glu Gly Gly Phe 
         275                280                285
Gln Gly Arg Cys Asn Lys Leu Val Asp Gly Cys Tyr Ser Phe Trp Gln 
     290                295                300
Ala Gly Leu Leu Pro Leu Leu His Arg Ala Leu His Ala Gln Gly Asp 
 305                310                315                320
Pro Ala Leu Ser Met Ser His Trp Met Phe His Gln Gln Ala Leu Gln 
                 325                330                335
Glu Tyr Ile Leu Met Cys Cys Gln Cys Pro Ala Gly Gly Leu Leu Asp 
             340                345                350
Lys Pro Gly Lys Ser Arg Asp Phe Tyr His Thr Cys Tyr Cys Leu Ser 
         355                360                365
Gly Leu Ser Ile Ala Gln His Phe Gly Ser Gly Ala Met Leu His Asp 
     370                375                380
Val Val Leu Gly Val Pro Glu Asn Ala Leu Gln Pro Thr His Pro Val 
 385                390                395                400
Tyr Asn Ile Gly Pro Asp Lys Val Ile Gln Ala Thr Thr Tyr Phe Leu 
                 405                410                415
Gln Lys Pro Val Pro Gly Phe Glu Glu Leu Lys Asp Glu Thr Ser Ala 
             420                425                430
Glu Pro Ala Thr Asp 
         435



<210> 6868
<211> 449
<212> DNA
<213> Rattus norvegicus
<308> AI136891
<400> 6868

ttttttttt  ttttcttga  aaaacgggg  ttattgatt  ttaaactgc  aatagtcgt  60
acaaaaagt  tttttttct  ttaaataaa  tcacacaaa  aaagagaaa  agaaagcga  120
ggtagtgac  agcaagagg  ataataatt  cattcatct  tatgtgtgt  ccagttgtt  180
acatcaaca  cggaaaact  caacctgga  tccagaacc  caaatctgc  agcggaatg  240
cttgagatg  gcacatgga  ttcaaaggg  ttttctctc  ctctctttt  ttttttttt  300
ttttccctt  tagaagcta  acataaatg  tggttttcc  tctgtactg  cacagaact  360
atacattct  agtcctacc  gtgaaaggc  taaggagaa  aaaaaacct  tgcggccgc  420
ccaacatca  aacctcgtg  cgaattctt  449



<210> 6869
<211> 338
<212> PRT
<213> Rattus norvegicus
<308> P17431
<400> 6869

Met Thr Thr Thr Leu Val Ser Ala Thr Ile Phe Asp Leu Ser Glu Val 
  1               5                  10                  15
Leu Cys Lys Gly Asn Lys Met Leu Asn Tyr Ser Thr Pro Ser Ala Gly 
             20                  25                  30
Gly Cys Leu Leu Asp Arg Lys Ala Val Gly Thr Pro Ala Gly Gly Gly 
         35                  40                  45
Phe Pro Arg Arg His Ser Val Thr Leu Pro Ser Ser Lys Phe His Gln 
     50                  55                  60
Asn Gln Leu Leu Ser Ser Leu Lys Gly Glu Pro Ala Pro Thr Leu Ser 
 65                  70                  75                  80
Ser Arg Asp Ser Arg Phe Arg Asp Arg Ser Phe Ser Glu Gly Gly Glu 
                 85                  90                  95
Arg Leu Leu Pro Thr Gln Lys Gln Pro Gly Ser Gly Gln Val Asn Ser 
             100                105                110
Ser Arg Tyr Lys Thr Glu Leu Cys Arg Pro Phe Glu Glu Asn Gly Ala 
         115                120                125
Cys Lys Tyr Gly Asp Lys Cys Gln Phe Ala His Gly Ile His Glu Leu 
     130                135                140
Arg Ser Leu Thr Arg His Pro Lys Tyr Lys Thr Glu Leu Cys Arg Thr 
 145                150                155                160
Phe His Thr Ile Gly Phe Cys Pro Tyr Gly Pro Arg Cys His Phe Ile 
                 165                170                175
His Asn Ala Glu Glu Arg Arg Ala Leu Ala Gly Gly Arg Asp Leu Ser 
             180                185                190
Ala Asp Arg Pro Arg Leu Gln His Ser Phe Ser Phe Ala Gly Phe Pro 
         195                200                205
Ser Ala Ala Ala Thr Ala Ala Ala Thr Gly Leu Leu Asp Ser Pro Thr 
     210                215                220
Ser Ile Thr Pro Pro Pro Ile Leu Ser Ala Asp Asp Leu Leu Gly Ser 
 225                230                235                240
Pro Thr Leu Pro Asp Gly Thr Asn Asn Pro Phe Ala Phe Ser Ser Gln 
                 245                250                255
Glu Leu Ala Ser Leu Phe Ala Pro Ser Met Gly Leu Pro Gly Gly Gly 
             260                265                270
Ser Pro Thr Thr Phe Leu Phe Arg Pro Met Ser Glu Ser Pro His Met 
         275                280                285
Phe Asp Ser Pro Pro Ser Pro Gln Asp Ser Leu Ser Asp His Glu Gly 
     290                295                300
Tyr Leu Ser Ser Ser Ser Ser Ser His Ser Gly Ser Asp Ser Pro Thr 
 305                310                315                320
Leu Asp Asn Ser Arg Arg Leu Pro Ile Phe Ser Arg Leu Ser Ile Ser 
                 325                330                335
Asp Asp 
             340



<210> 6870
<211> 290
<212> DNA
<213> Homo sapiens
<308> AI902540
<400> 6870

gacggagac  tcagctgcg  gagtccagt  acagtcgtg  acagagacg  aggtcaggc  60
cttcctgta  cagtgcagg  cggtgagca  catgtggga  gagtccagc  agtggatga  120
gtggcagcg  ggcccgtag  ggcaaaagc  gatggtgtg  aaggtgcgg  acagctccg  180
cttgtactt  gggtggcgg  tcaggctgc  gagctcgtg  atgccgtgt  cgaactggc  240
cttgtcccc  tacttacag  caccgtttt  ctcaaaggg  cggcacagct  290



<210> 6871
<211> 1230
<212> PRT
<213> Homo sapiens
<308> O00411
<400> 6871

Met Ser Ala Leu Cys Trp Gly Arg Gly Ala Ala Gly Leu Lys Arg Ala 
  1               5                  10                  15
Leu Arg Pro Cys Gly Arg Pro Gly Leu Pro Gly Lys Glu Gly Thr Ala 
             20                  25                  30
Gly Gly Val Cys Gly Pro Arg Arg Ser Ser Ser Ala Ser Pro Gln Glu 
         35                  40                  45
Gln Asp Gln Asp Arg Arg Lys Asp Trp Gly His Val Glu Leu Leu Glu 
     50                  55                  60
Val Leu Gln Ala Arg Val Arg Gln Leu Gln Ala Glu Ser Val Ser Glu 
 65                  70                  75                  80
Val Val Val Asn Arg Val Asp Val Ala Arg Leu Pro Glu Cys Gly Ser 
                 85                  90                  95
Gly Asp Gly Ser Leu Gln Pro Pro Arg Lys Val Gln Met Gly Ala Lys 
             100                105                110
Asp Ala Thr Pro Val Pro Cys Gly Arg Trp Ala Lys Ile Leu Glu Lys 
         115                120                125
Asp Lys Arg Thr Gln Gln Met Arg Met Gln Arg Leu Lys Ala Lys Leu 
     130                135                140
Gln Met Pro Phe Gln Ser Gly Glu Phe Lys Ala Leu Thr Arg Arg Leu 
 145                150                155                160
Gln Val Glu Pro Arg Leu Leu Ser Lys Gln Met Ala Gly Cys Leu Glu 
                 165                170                175
Asp Cys Thr Arg Gln Ala Pro Glu Ser Pro Trp Glu Glu Gln Leu Ala 
             180                185                190
Arg Leu Leu Gln Glu Ala Pro Gly Lys Leu Ser Leu Asp Val Glu Gln 
         195                200                205
Ala Pro Ser Gly Gln His Ser Gln Ala Gln Leu Ser Gly Gln Gln Gln 
     210                215                220
Arg Leu Leu Ala Phe Phe Lys Cys Cys Leu Leu Thr Asp Gln Leu Pro 
 225                230                235                240
Leu Ala His His Leu Leu Val Val His His Gly Gln Arg Gln Lys Arg 
                 245                250                255
Lys Leu Leu Thr Leu Asp Met Tyr Asn Ala Val Met Leu Gly Trp Ala 
             260                265                270
Arg Gln Gly Ala Phe Lys Glu Leu Val Tyr Val Leu Phe Met Val Lys 
         275                280                285
Asp Ala Gly Leu Thr Pro Asp Leu Leu Ser Tyr Ala Ala Ala Leu Gln 
     290                295                300
Cys Met Gly Arg Gln Asp Gln Asp Ala Gly Thr Ile Glu Arg Cys Leu 
 305                310                315                320
Glu Gln Met Ser Gln Glu Gly Leu Lys Leu Gln Ala Leu Phe Thr Ala 
                 325                330                335
Val Leu Leu Ser Glu Glu Asp Arg Ala Thr Val Leu Lys Ala Val His 
             340                345                350
Lys Val Lys Pro Thr Phe Ser Leu Pro Pro Gln Leu Pro Pro Pro Val 
         355                360                365
Asn Thr Ser Lys Leu Leu Arg Asp Val Tyr Ala Lys Asp Gly Arg Val 
     370                375                380
Ser Tyr Pro Lys Leu His Leu Pro Leu Lys Thr Leu Gln Cys Phe Phe 
 385                390                395                400
Glu Lys Gln Leu His Met Glu Leu Ala Ser Arg Val Cys Val Val Ser 
                 405                410                415
Val Glu Lys Pro Thr Leu Pro Ser Lys Glu Val Lys His Ala Arg Lys 
             420                425                430
Thr Leu Lys Thr Leu Arg Asp Gln Trp Glu Lys Ala Leu Cys Arg Ala 
         435                440                445
Leu Arg Glu Thr Lys Asn Arg Leu Glu Arg Glu Val Tyr Glu Gly Arg 
     450                455                460
Phe Ser Leu Tyr Pro Phe Leu Cys Leu Leu Asp Glu Arg Glu Val Val 
 465                470                475                480
Arg Met Leu Leu Gln Val Leu Gln Ala Leu Pro Ala Gln Gly Glu Ser 
                 485                490                495
Phe Thr Thr Leu Ala Arg Glu Leu Ser Ala Arg Thr Phe Ser Arg His 
             500                505                510
Val Val Gln Arg Gln Arg Val Ser Gly Gln Val Gln Ala Leu Gln Asn 
         515                520                525
His Tyr Arg Lys Tyr Leu Cys Leu Leu Ala Ser Asp Ala Glu Val Pro 
     530                535                540
Glu Pro Cys Leu Pro Arg Gln Tyr Trp Glu Glu Leu Gly Ala Pro Glu 
 545                550                555                560
Ala Leu Arg Glu Gln Pro Trp Pro Leu Pro Val Gln Met Glu Leu Gly 
                 565                570                575
Lys Leu Leu Ala Glu Met Leu Val Gln Ala Thr Gln Met Pro Cys Ser 
             580                585                590
Leu Asp Lys Pro His Arg Ser Ser Arg Leu Val Pro Val Leu Tyr His 
         595                600                605
Val Tyr Ser Phe Arg Asn Val Gln Gln Ile Gly Ile Leu Lys Pro His 
     610                615                620
Pro Ala Tyr Val Gln Leu Leu Glu Lys Ala Ala Glu Pro Thr Leu Thr 
 625                630                635                640
Phe Glu Ala Val Asp Val Pro Met Leu Cys Pro Pro Leu Pro Trp Thr 
                 645                650                655
Ser Pro His Ser Gly Ala Phe Leu Leu Ser Pro Thr Lys Leu Met Arg 
             660                665                670
Thr Val Glu Gly Ala Thr Gln His Gln Glu Leu Leu Glu Thr Cys Pro 
         675                680                685
Pro Thr Ala Leu His Gly Ala Leu Asp Ala Leu Thr Gln Leu Gly Asn 
     690                695                700
Cys Ala Trp Arg Val Asn Gly Arg Val Leu Asp Leu Val Leu Gln Leu 
 705                710                715                720
Phe Gln Ala Lys Gly Cys Pro Gln Leu Gly Val Pro Ala Pro Pro Ser 
                 725                730                735
Glu Ala Pro Gln Pro Pro Glu Ala His Leu Pro His Ser Ala Ala Pro 
             740                745                750
Ala Arg Lys Ala Glu Leu Arg Arg Glu Leu Ala His Cys Gln Lys Val 
         755                760                765
Ala Arg Glu Met His Ser Leu Arg Ala Glu Ala Leu Tyr Arg Leu Ser 
     770                775                780
Leu Ala Gln His Leu Arg Asp Arg Val Phe Trp Leu Pro His Asn Met 
 785                790                795                800
Asp Phe Arg Gly Arg Thr Tyr Pro Cys Pro Pro His Phe Asn His Leu 
                 805                810                815
Gly Ser Asp Val Ala Arg Ala Leu Leu Glu Phe Ala Gln Gly Arg Pro 
             820                825                830
Leu Gly Pro His Gly Leu Asp Trp Leu Lys Ile His Leu Val Asn Leu 
         835                840                845
Thr Gly Leu Lys Lys Arg Glu Pro Leu Arg Lys Arg Leu Ala Phe Ala 
     850                855                860
Glu Glu Val Met Asp Asp Ile Leu Asp Ser Ala Asp Gln Pro Leu Thr 
 865                870                875                880
Gly Arg Lys Trp Trp Met Gly Ala Glu Glu Pro Trp Gln Thr Leu Ala 
                 885                890                895
Cys Cys Met Glu Val Ala Asn Ala Val Arg Ala Ser Asp Pro Ala Ala 
             900                905                910
Tyr Val Ser His Leu Pro Val His Gln Asp Gly Ser Cys Asn Gly Leu 
         915                920                925
Gln His Tyr Ala Ala Leu Gly Arg Asp Ser Val Gly Ala Ala Ser Val 
     930                935                940
Asn Leu Glu Pro Ser Asp Val Pro Gln Asp Val Tyr Ser Gly Val Ala 
 945                950                955                960
Ala Gln Val Glu Val Phe Arg Arg Gln Asp Ala Gln Arg Gly Met Arg 
                 965                970                975
Val Ala Gln Val Leu Glu Ser Phe Ile Thr Arg Lys Val Val Lys Gln 
             980                985                990
Thr Val Met Thr Val Val Tyr Gly Val Thr Arg Tyr Gly Gly Arg Leu 
         995                1000                1005
Gln Ile Glu Lys Arg Leu Arg Glu Leu Ser Asp Phe Pro Gln Glu Phe 
     1010                1015                1020
Val Trp Glu Ala Ser His Tyr Leu Val Arg Gln Val Phe Lys Ser Leu 
 1025                1030                1035                1040
Gln Glu Met Phe Ser Gly Thr Arg Ala Ile Gln His Trp Leu Thr Glu 
                 1045                1050                1055
Ser Ala Arg Leu Ile Ser His Met Gly Ser Val Val Glu Trp Val Thr 
             1060                1065                1070
Pro Leu Gly Val Pro Val Ile Gln Pro Tyr Arg Leu Asp Ser Lys Val 
         1075                1080                1085
Lys Gln Ile Gly Gly Gly Ile Gln Ser Ile Thr Tyr Thr His Asn Gly 
     1090                1095                1100
Asp Ile Ser Arg Lys Pro Asn Thr Arg Lys Gln Lys Asn Gly Phe Pro 
 1105                1110                1115                1120
Pro Asn Phe Ile His Ser Leu Asp Ser Ser His Met Met Leu Thr Ala 
                 1125                1130                1135
Leu His Cys Tyr Arg Lys Gly Leu Thr Phe Val Ser Val His Asp Cys 
             1140                1145                1150
Tyr Trp Thr His Ala Ala Asp Val Ser Val Met Asn Gln Val Cys Arg 
         1155                1160                1165
Glu Gln Phe Val Arg Leu His Ser Glu Pro Ile Leu Gln Asp Leu Ser 
     1170                1175                1180
Arg Phe Leu Val Lys Arg Phe Cys Ser Glu Pro Gln Lys Ile Leu Glu 
 1185                1190                1195                1200
Ala Ser Gln Leu Lys Glu Thr Leu Gln Ala Val Pro Lys Pro Gly Ala 
                 1205                1210                1215
Phe Asp Leu Glu Gln Val Lys Arg Ser Thr Tyr Phe Phe Ser 
             1220                1225                1230



<210> 6872
<211> 376
<212> DNA
<213> Rattus norvegicus
<308> AI136977
<400> 6872

ttttttttt  tttttttaa  tcactcaaa  ttcttcagt  tttacaaaa  taacagggt  60
gagtaggga  gggagcagg  aggcagccg  aggggtggg  aggcggaga  gcaggctat  120
cttctgtct  cacctgagc  tggttgcct  ccacattgt  cggctcacc  ttcatctca  180
catcagtgg  atggtccac  tcaaataca  gtgtggcat  tggttgcca  agcaatatc  240
caagccttg  tgacctccc  ttttcccag  tcaaaggag  atttgtcct  gcggtccaa  300
ctggagtca  actttgtgc  atctagcag  cagccagtg  agtggacaa  gactcggtc  360
cccctcgtg  cgaatt  376



<210> 6873
<211> 2156
<212> DNA
<213> Homo sapiens
<308> M88279
<400> 6873

cccggcctc  cgcacgccc  gcaggtagc  cccccgccc  cggcccaga  tgcgctcgc  60
ccggcacca  ctcccggat  aacggcgcg  cgcgcggag  tgacagccg  ggagatgaa  120
gcgaccgag  gcggggcgc  gtcggcgcc  ctgcccatg  agggagtgg  catcagccc  180
aaacaggac  aaggcgtgc  gaaggtcat  aagagagag  gcacaggta  agagatgcc  240
atgattggg  accgagtct  tgtccacta  actggctgg  tattagatg  cacaaagtt  300
gactccagt  tggatcgca  ggacaaatt  tcctttgac  tgggaaaag  ggaggtcat  360
aaggcttgg  acattgcca  agccaccat  aaggtgggg  aggtgtgcc  catcacctg  420
aaaccagaa  atgcctacg  ttcagcagg  agtcctcca  agattcccc  caatgccac  480
cttgtattt  aggtggagt  gtttgagtt  aagggagaa  atctgacgg  agaggaaga  540
ggcggaatc  ttcgcagaa  acagactcg  ggtgaaggc  atgctaagc  caatgaggg  600
gctatcgtg  aggttgcac  ggaagggta  tacaaggac  agctctttg  ccagcggga  660
ctccgcttt  agattggcg  gggggagaa  ctggatctg  cttatggtc  ggagagggc  720
attcagcgc  tggagaaag  agaacattc  atcgtgtac  tcaagccca  ctatgcttt  780
ggcagtgtt  ggaaggaaa  gttccaaat  ccaccaaat  ctgagctga  atatgaatt  840
cacctcaag  gttttgaaa  ggccaagga  tcttgggag  tgaattcag  agagaagct  900
gaacagagc  ccatagtga  agagcgggg  actgtgtac  tcaaggaag  taaatacaa  960
caagcttta  tacagtata  gaagatcgt  tcttggctg  aatatgagt  tagtttttc  1020
aatgaggaa  cacagaaag  acaggccct  cgactggcc  ctcacctca  cctggccat  1080
tgtcatctg  aactacagg  cttctctgc  gccattgaa  gctgtaaca  ggccctaga  1140
ctggacagc  acaacgaga  gggcctctt  cgccgggga  aggcccacc  ggccgtgaa  1200
gactttgaa  tggcacggg  tgatttcca  aaggtcctg  agctctacc  caacaacaa  1260
gccgccaag  cccagctgg  tgtgtgcca  cagcggatc  gaaggcagc  tgcccggga  1320
aagaagctc  atgccaata  gtttgagag  ctggctgag  aggagaaca  ggccaaggc  1380
gaggcttcc  caggagacc  tcccactga  acagagatg  aggaggagc  gaagagcaa  1440
acggcaggg  gccagtctc  ggtggagac  gaagcatag  ccctctcca  cagccctac  1500
cctgcggct  cctgccccc  agtctcccc  ctccaccct  ttagttttg  aaaaactga  1560
gaattttga  tgaattaga  ctttatttt  ctatctggt  ggatggtgg  tttagggga  1620
gggggaaag  tgtaggctg  gggattgag  tggggaatc  ttttagctg  tgtcagccc  1680
tcttccctt  ctccattgc  catgaacat  tgtccatcc  tatatattc  tcagaatgt  1740
aatttattt  gctccctct  ttaggtcca  tttctaagg  tagaagagg  aagtggtag  1800
gatgaggtc  gataagaac  cagggtgga  agggagact  ctgggcagc  gttttcctc  1860
tcctttccc  ctcccagtc  atttccaaa  gtggcctcc  tgtgggtgc  agggacatg  1920
gaaaaacca  tgctatgcc  tttcttctc  ctgttccct  cctcacccc  gacggtgtg  1980
ctgatgatg  cttctggtg  catggtgac  accccctgt  ccctgttct  gtatttccc  2040
tgtcagttt  ccctctcgg  caggttgtg  cccaaaatc  cctcagcct  ttctctgca  2100
gttgctgaa  gtccaggct  gcctcaagt  ccatgcttg  gcaataaag  ggaaac  2156



<210> 6874
<211> 458
<212> PRT
<213> Homo sapiens
<308> Q02790
<400> 6874

Thr Ala Glu Glu Met Lys Ala Thr Glu Ser Gly Ala Gln Ser Ala Pro 
  1               5                  10                  15
Leu Pro Met Glu Gly Val Asp Ile Ser Pro Lys Gln Asp Glu Gly Val 
             20                  25                  30
Leu Lys Val Ile Lys Arg Glu Gly Thr Gly Thr Glu Met Pro Met Ile 
         35                  40                  45
Gly Asp Arg Val Phe Val His Tyr Thr Gly Trp Leu Leu Asp Gly Thr 
     50                  55                  60
Lys Phe Asp Ser Ser Leu Asp Arg Lys Asp Lys Phe Ser Phe Asp Leu 
 65                  70                  75                  80
Gly Lys Gly Glu Val Ile Lys Ala Trp Asp Ile Ala Ile Ala Thr Met 
                 85                  90                  95
Lys Val Gly Glu Val Cys His Ile Thr Cys Lys Pro Glu Tyr Ala Tyr 
             100                105                110
Gly Ser Ala Gly Ser Pro Pro Lys Ile Pro Pro Asn Ala Thr Leu Val 
         115                120                125
Phe Glu Val Glu Leu Phe Glu Phe Lys Gly Glu Asp Leu Thr Glu Glu 
     130                135                140
Glu Asp Gly Gly Ile Ile Arg Arg Ile Gln Thr Arg Gly Glu Gly Tyr 
 145                150                155                160
Ala Lys Pro Asn Glu Gly Ala Ile Val Glu Val Ala Leu Glu Gly Tyr 
                 165                170                175
Tyr Lys Asp Lys Leu Phe Asp Gln Arg Glu Leu Arg Phe Glu Ile Gly 
             180                185                190
Glu Gly Glu Asn Leu Asp Leu Pro Tyr Gly Leu Glu Arg Ala Ile Gln 
         195                200                205
Arg Met Glu Lys Gly Glu His Ser Ile Val Tyr Leu Lys Pro Ser Tyr 
     210                215                220
Ala Phe Gly Ser Val Gly Lys Glu Lys Phe Gln Ile Pro Pro Asn Ala 
 225                230                235                240
Glu Leu Lys Tyr Glu Leu His Leu Lys Ser Phe Glu Lys Ala Lys Glu 
                 245                250                255
Ser Trp Glu Met Asn Ser Glu Glu Lys Leu Glu Gln Ser Thr Ile Val 
             260                265                270
Lys Glu Arg Gly Thr Val Tyr Phe Lys Glu Gly Lys Tyr Lys Gln Ala 
         275                280                285
Leu Leu Gln Tyr Lys Lys Ile Val Ser Trp Leu Glu Tyr Glu Ser Ser 
     290                295                300
Phe Ser Asn Glu Glu Ala Gln Lys Ala Gln Ala Leu Arg Leu Ala Ser 
 305                310                315                320
His Leu Asn Leu Ala Met Cys His Leu Lys Leu Gln Ala Phe Ser Ala 
                 325                330                335
Ala Ile Glu Ser Cys Asn Lys Ala Leu Glu Leu Asp Ser Asn Asn Glu 
             340                345                350
Lys Gly Leu Phe Arg Arg Gly Glu Ala His Leu Ala Val Asn Asp Phe 
         355                360                365
Glu Leu Ala Arg Ala Asp Phe Gln Lys Val Leu Gln Leu Tyr Pro Asn 
     370                375                380
Asn Lys Ala Ala Lys Thr Gln Leu Ala Val Cys Gln Gln Arg Ile Arg 
 385                390                395                400
Arg Gln Leu Ala Arg Glu Lys Lys Leu Tyr Ala Asn Met Phe Glu Arg 
                 405                410                415
Leu Ala Glu Glu Glu Asn Lys Ala Lys Ala Glu Ala Ser Ser Gly Asp 
             420                425                430
His Pro Thr Asp Thr Glu Met Lys Glu Glu Gln Lys Ser Asn Thr Ala 
         435                440                445
Gly Ser Gln Ser Gln Val Glu Thr Glu Ala 
     450                455



<210> 6875
<211> 376
<212> DNA
<213> Rattus norvegicus
<308> AI136977
<400> 6875

ttttttttt  tttttttaa  tcactcaaa  ttcttcagt  tttacaaaa  taacagggt  60
gagtaggga  gggagcagg  aggcagccg  aggggtggg  aggcggaga  gcaggctat  120
cttctgtct  cacctgagc  tggttgcct  ccacattgt  cggctcacc  ttcatctca  180
catcagtgg  atggtccac  tcaaataca  gtgtggcat  tggttgcca  agcaatatc  240
caagccttg  tgacctccc  ttttcccag  tcaaaggag  atttgtcct  gcggtccaa  300
ctggagtca  actttgtgc  atctagcag  cagccagtg  agtggacaa  gactcggtc  360
cccctcgtg  cgaatt  376



<210> 6876
<211> 2156
<212> DNA
<213> Homo sapiens
<308> M88279
<400> 6876

cccggcctc  cgcacgccc  gcaggtagc  cccccgccc  cggcccaga  tgcgctcgc  60
ccggcacca  ctcccggat  aacggcgcg  cgcgcggag  tgacagccg  ggagatgaa  120
gcgaccgag  gcggggcgc  gtcggcgcc  ctgcccatg  agggagtgg  catcagccc  180
aaacaggac  aaggcgtgc  gaaggtcat  aagagagag  gcacaggta  agagatgcc  240
atgattggg  accgagtct  tgtccacta  actggctgg  tattagatg  cacaaagtt  300
gactccagt  tggatcgca  ggacaaatt  tcctttgac  tgggaaaag  ggaggtcat  360
aaggcttgg  acattgcca  agccaccat  aaggtgggg  aggtgtgcc  catcacctg  420
aaaccagaa  atgcctacg  ttcagcagg  agtcctcca  agattcccc  caatgccac  480
cttgtattt  aggtggagt  gtttgagtt  aagggagaa  atctgacgg  agaggaaga  540
ggcggaatc  ttcgcagaa  acagactcg  ggtgaaggc  atgctaagc  caatgaggg  600
gctatcgtg  aggttgcac  ggaagggta  tacaaggac  agctctttg  ccagcggga  660
ctccgcttt  agattggcg  gggggagaa  ctggatctg  cttatggtc  ggagagggc  720
attcagcgc  tggagaaag  agaacattc  atcgtgtac  tcaagccca  ctatgcttt  780
ggcagtgtt  ggaaggaaa  gttccaaat  ccaccaaat  ctgagctga  atatgaatt  840
cacctcaag  gttttgaaa  ggccaagga  tcttgggag  tgaattcag  agagaagct  900
gaacagagc  ccatagtga  agagcgggg  actgtgtac  tcaaggaag  taaatacaa  960
caagcttta  tacagtata  gaagatcgt  tcttggctg  aatatgagt  tagtttttc  1020
aatgaggaa  cacagaaag  acaggccct  cgactggcc  ctcacctca  cctggccat  1080
tgtcatctg  aactacagg  cttctctgc  gccattgaa  gctgtaaca  ggccctaga  1140
ctggacagc  acaacgaga  gggcctctt  cgccgggga  aggcccacc  ggccgtgaa  1200
gactttgaa  tggcacggg  tgatttcca  aaggtcctg  agctctacc  caacaacaa  1260
gccgccaag  cccagctgg  tgtgtgcca  cagcggatc  gaaggcagc  tgcccggga  1320
aagaagctc  atgccaata  gtttgagag  ctggctgag  aggagaaca  ggccaaggc  1380
gaggcttcc  caggagacc  tcccactga  acagagatg  aggaggagc  gaagagcaa  1440
acggcaggg  gccagtctc  ggtggagac  gaagcatag  ccctctcca  cagccctac  1500
cctgcggct  cctgccccc  agtctcccc  ctccaccct  ttagttttg  aaaaactga  1560
gaattttga  tgaattaga  ctttatttt  ctatctggt  ggatggtgg  tttagggga  1620
gggggaaag  tgtaggctg  gggattgag  tggggaatc  ttttagctg  tgtcagccc  1680
tcttccctt  ctccattgc  catgaacat  tgtccatcc  tatatattc  tcagaatgt  1740
aatttattt  gctccctct  ttaggtcca  tttctaagg  tagaagagg  aagtggtag  1800
gatgaggtc  gataagaac  cagggtgga  agggagact  ctgggcagc  gttttcctc  1860
tcctttccc  ctcccagtc  atttccaaa  gtggcctcc  tgtgggtgc  agggacatg  1920
gaaaaacca  tgctatgcc  tttcttctc  ctgttccct  cctcacccc  gacggtgtg  1980
ctgatgatg  cttctggtg  catggtgac  accccctgt  ccctgttct  gtatttccc  2040
tgtcagttt  ccctctcgg  caggttgtg  cccaaaatc  cctcagcct  ttctctgca  2100
gttgctgaa  gtccaggct  gcctcaagt  ccatgcttg  gcaataaag  ggaaac  2156



<210> 6877
<211> 458
<212> PRT
<213> Homo sapiens
<308> Q02790
<400> 6877

Thr Ala Glu Glu Met Lys Ala Thr Glu Ser Gly Ala Gln Ser Ala Pro 
  1               5                  10                  15
Leu Pro Met Glu Gly Val Asp Ile Ser Pro Lys Gln Asp Glu Gly Val 
             20                  25                  30
Leu Lys Val Ile Lys Arg Glu Gly Thr Gly Thr Glu Met Pro Met Ile 
         35                  40                  45
Gly Asp Arg Val Phe Val His Tyr Thr Gly Trp Leu Leu Asp Gly Thr 
     50                  55                  60
Lys Phe Asp Ser Ser Leu Asp Arg Lys Asp Lys Phe Ser Phe Asp Leu 
 65                  70                  75                  80
Gly Lys Gly Glu Val Ile Lys Ala Trp Asp Ile Ala Ile Ala Thr Met 
                 85                  90                  95
Lys Val Gly Glu Val Cys His Ile Thr Cys Lys Pro Glu Tyr Ala Tyr 
             100                105                110
Gly Ser Ala Gly Ser Pro Pro Lys Ile Pro Pro Asn Ala Thr Leu Val 
         115                120                125
Phe Glu Val Glu Leu Phe Glu Phe Lys Gly Glu Asp Leu Thr Glu Glu 
     130                135                140
Glu Asp Gly Gly Ile Ile Arg Arg Ile Gln Thr Arg Gly Glu Gly Tyr 
 145                150                155                160
Ala Lys Pro Asn Glu Gly Ala Ile Val Glu Val Ala Leu Glu Gly Tyr 
                 165                170                175
Tyr Lys Asp Lys Leu Phe Asp Gln Arg Glu Leu Arg Phe Glu Ile Gly 
             180                185                190
Glu Gly Glu Asn Leu Asp Leu Pro Tyr Gly Leu Glu Arg Ala Ile Gln 
         195                200                205
Arg Met Glu Lys Gly Glu His Ser Ile Val Tyr Leu Lys Pro Ser Tyr 
     210                215                220
Ala Phe Gly Ser Val Gly Lys Glu Lys Phe Gln Ile Pro Pro Asn Ala 
 225                230                235                240
Glu Leu Lys Tyr Glu Leu His Leu Lys Ser Phe Glu Lys Ala Lys Glu 
                 245                250                255
Ser Trp Glu Met Asn Ser Glu Glu Lys Leu Glu Gln Ser Thr Ile Val 
             260                265                270
Lys Glu Arg Gly Thr Val Tyr Phe Lys Glu Gly Lys Tyr Lys Gln Ala 
         275                280                285
Leu Leu Gln Tyr Lys Lys Ile Val Ser Trp Leu Glu Tyr Glu Ser Ser 
     290                295                300
Phe Ser Asn Glu Glu Ala Gln Lys Ala Gln Ala Leu Arg Leu Ala Ser 
 305                310                315                320
His Leu Asn Leu Ala Met Cys His Leu Lys Leu Gln Ala Phe Ser Ala 
                 325                330                335
Ala Ile Glu Ser Cys Asn Lys Ala Leu Glu Leu Asp Ser Asn Asn Glu 
             340                345                350
Lys Gly Leu Phe Arg Arg Gly Glu Ala His Leu Ala Val Asn Asp Phe 
         355                360                365
Glu Leu Ala Arg Ala Asp Phe Gln Lys Val Leu Gln Leu Tyr Pro Asn 
     370                375                380
Asn Lys Ala Ala Lys Thr Gln Leu Ala Val Cys Gln Gln Arg Ile Arg 
 385                390                395                400
Arg Gln Leu Ala Arg Glu Lys Lys Leu Tyr Ala Asn Met Phe Glu Arg 
                 405                410                415
Leu Ala Glu Glu Glu Asn Lys Ala Lys Ala Glu Ala Ser Ser Gly Asp 
             420                425                430
His Pro Thr Asp Thr Glu Met Lys Glu Glu Gln Lys Ser Asn Thr Ala 
         435                440                445
Gly Ser Gln Ser Gln Val Glu Thr Glu Ala 
     450                455



<210> 6878
<211> 376
<212> DNA
<213> Rattus norvegicus
<308> AI136977
<400> 6878

ttttttttt  tttttttaa  tcactcaaa  ttcttcagt  tttacaaaa  taacagggt  60
gagtaggga  gggagcagg  aggcagccg  aggggtggg  aggcggaga  gcaggctat  120
cttctgtct  cacctgagc  tggttgcct  ccacattgt  cggctcacc  ttcatctca  180
catcagtgg  atggtccac  tcaaataca  gtgtggcat  tggttgcca  agcaatatc  240
caagccttg  tgacctccc  ttttcccag  tcaaaggag  atttgtcct  gcggtccaa  300
ctggagtca  actttgtgc  atctagcag  cagccagtg  agtggacaa  gactcggtc  360
cccctcgtg  cgaatt  376



<210> 6879
<211> 2156
<212> DNA
<213> Homo sapiens
<308> M88279
<400> 6879

cccggcctc  cgcacgccc  gcaggtagc  cccccgccc  cggcccaga  tgcgctcgc  60
ccggcacca  ctcccggat  aacggcgcg  cgcgcggag  tgacagccg  ggagatgaa  120
gcgaccgag  gcggggcgc  gtcggcgcc  ctgcccatg  agggagtgg  catcagccc  180
aaacaggac  aaggcgtgc  gaaggtcat  aagagagag  gcacaggta  agagatgcc  240
atgattggg  accgagtct  tgtccacta  actggctgg  tattagatg  cacaaagtt  300
gactccagt  tggatcgca  ggacaaatt  tcctttgac  tgggaaaag  ggaggtcat  360
aaggcttgg  acattgcca  agccaccat  aaggtgggg  aggtgtgcc  catcacctg  420
aaaccagaa  atgcctacg  ttcagcagg  agtcctcca  agattcccc  caatgccac  480
cttgtattt  aggtggagt  gtttgagtt  aagggagaa  atctgacgg  agaggaaga  540
ggcggaatc  ttcgcagaa  acagactcg  ggtgaaggc  atgctaagc  caatgaggg  600
gctatcgtg  aggttgcac  ggaagggta  tacaaggac  agctctttg  ccagcggga  660
ctccgcttt  agattggcg  gggggagaa  ctggatctg  cttatggtc  ggagagggc  720
attcagcgc  tggagaaag  agaacattc  atcgtgtac  tcaagccca  ctatgcttt  780
ggcagtgtt  ggaaggaaa  gttccaaat  ccaccaaat  ctgagctga  atatgaatt  840
cacctcaag  gttttgaaa  ggccaagga  tcttgggag  tgaattcag  agagaagct  900
gaacagagc  ccatagtga  agagcgggg  actgtgtac  tcaaggaag  taaatacaa  960
caagcttta  tacagtata  gaagatcgt  tcttggctg  aatatgagt  tagtttttc  1020
aatgaggaa  cacagaaag  acaggccct  cgactggcc  ctcacctca  cctggccat  1080
tgtcatctg  aactacagg  cttctctgc  gccattgaa  gctgtaaca  ggccctaga  1140
ctggacagc  acaacgaga  gggcctctt  cgccgggga  aggcccacc  ggccgtgaa  1200
gactttgaa  tggcacggg  tgatttcca  aaggtcctg  agctctacc  caacaacaa  1260
gccgccaag  cccagctgg  tgtgtgcca  cagcggatc  gaaggcagc  tgcccggga  1320
aagaagctc  atgccaata  gtttgagag  ctggctgag  aggagaaca  ggccaaggc  1380
gaggcttcc  caggagacc  tcccactga  acagagatg  aggaggagc  gaagagcaa  1440
acggcaggg  gccagtctc  ggtggagac  gaagcatag  ccctctcca  cagccctac  1500
cctgcggct  cctgccccc  agtctcccc  ctccaccct  ttagttttg  aaaaactga  1560
gaattttga  tgaattaga  ctttatttt  ctatctggt  ggatggtgg  tttagggga  1620
gggggaaag  tgtaggctg  gggattgag  tggggaatc  ttttagctg  tgtcagccc  1680
tcttccctt  ctccattgc  catgaacat  tgtccatcc  tatatattc  tcagaatgt  1740
aatttattt  gctccctct  ttaggtcca  tttctaagg  tagaagagg  aagtggtag  1800
gatgaggtc  gataagaac  cagggtgga  agggagact  ctgggcagc  gttttcctc  1860
tcctttccc  ctcccagtc  atttccaaa  gtggcctcc  tgtgggtgc  agggacatg  1920
gaaaaacca  tgctatgcc  tttcttctc  ctgttccct  cctcacccc  gacggtgtg  1980
ctgatgatg  cttctggtg  catggtgac  accccctgt  ccctgttct  gtatttccc  2040
tgtcagttt  ccctctcgg  caggttgtg  cccaaaatc  cctcagcct  ttctctgca  2100
gttgctgaa  gtccaggct  gcctcaagt  ccatgcttg  gcaataaag  ggaaac  2156



<210> 6880
<211> 458
<212> PRT
<213> Homo sapiens
<308> Q02790
<400> 6880

Thr Ala Glu Glu Met Lys Ala Thr Glu Ser Gly Ala Gln Ser Ala Pro 
  1               5                  10                  15
Leu Pro Met Glu Gly Val Asp Ile Ser Pro Lys Gln Asp Glu Gly Val 
             20                  25                  30
Leu Lys Val Ile Lys Arg Glu Gly Thr Gly Thr Glu Met Pro Met Ile 
         35                  40                  45
Gly Asp Arg Val Phe Val His Tyr Thr Gly Trp Leu Leu Asp Gly Thr 
     50                  55                  60
Lys Phe Asp Ser Ser Leu Asp Arg Lys Asp Lys Phe Ser Phe Asp Leu 
 65                  70                  75                  80
Gly Lys Gly Glu Val Ile Lys Ala Trp Asp Ile Ala Ile Ala Thr Met 
                 85                  90                  95
Lys Val Gly Glu Val Cys His Ile Thr Cys Lys Pro Glu Tyr Ala Tyr 
             100                105                110
Gly Ser Ala Gly Ser Pro Pro Lys Ile Pro Pro Asn Ala Thr Leu Val 
         115                120                125
Phe Glu Val Glu Leu Phe Glu Phe Lys Gly Glu Asp Leu Thr Glu Glu 
     130                135                140
Glu Asp Gly Gly Ile Ile Arg Arg Ile Gln Thr Arg Gly Glu Gly Tyr 
 145                150                155                160
Ala Lys Pro Asn Glu Gly Ala Ile Val Glu Val Ala Leu Glu Gly Tyr 
                 165                170                175
Tyr Lys Asp Lys Leu Phe Asp Gln Arg Glu Leu Arg Phe Glu Ile Gly 
             180                185                190
Glu Gly Glu Asn Leu Asp Leu Pro Tyr Gly Leu Glu Arg Ala Ile Gln 
         195                200                205
Arg Met Glu Lys Gly Glu His Ser Ile Val Tyr Leu Lys Pro Ser Tyr 
     210                215                220
Ala Phe Gly Ser Val Gly Lys Glu Lys Phe Gln Ile Pro Pro Asn Ala 
 225                230                235                240
Glu Leu Lys Tyr Glu Leu His Leu Lys Ser Phe Glu Lys Ala Lys Glu 
                 245                250                255
Ser Trp Glu Met Asn Ser Glu Glu Lys Leu Glu Gln Ser Thr Ile Val 
             260                265                270
Lys Glu Arg Gly Thr Val Tyr Phe Lys Glu Gly Lys Tyr Lys Gln Ala 
         275                280                285
Leu Leu Gln Tyr Lys Lys Ile Val Ser Trp Leu Glu Tyr Glu Ser Ser 
     290                295                300
Phe Ser Asn Glu Glu Ala Gln Lys Ala Gln Ala Leu Arg Leu Ala Ser 
 305                310                315                320
His Leu Asn Leu Ala Met Cys His Leu Lys Leu Gln Ala Phe Ser Ala 
                 325                330                335
Ala Ile Glu Ser Cys Asn Lys Ala Leu Glu Leu Asp Ser Asn Asn Glu 
             340                345                350
Lys Gly Leu Phe Arg Arg Gly Glu Ala His Leu Ala Val Asn Asp Phe 
         355                360                365
Glu Leu Ala Arg Ala Asp Phe Gln Lys Val Leu Gln Leu Tyr Pro Asn 
     370                375                380
Asn Lys Ala Ala Lys Thr Gln Leu Ala Val Cys Gln Gln Arg Ile Arg 
 385                390                395                400
Arg Gln Leu Ala Arg Glu Lys Lys Leu Tyr Ala Asn Met Phe Glu Arg 
                 405                410                415
Leu Ala Glu Glu Glu Asn Lys Ala Lys Ala Glu Ala Ser Ser Gly Asp 
             420                425                430
His Pro Thr Asp Thr Glu Met Lys Glu Glu Gln Lys Ser Asn Thr Ala 
         435                440                445
Gly Ser Gln Ser Gln Val Glu Thr Glu Ala 
     450                455



<210> 6881
<211> 376
<212> DNA
<213> Rattus norvegicus
<308> AI136977
<400> 6881

ttttttttt  tttttttaa  tcactcaaa  ttcttcagt  tttacaaaa  taacagggt  60
gagtaggga  gggagcagg  aggcagccg  aggggtggg  aggcggaga  gcaggctat  120
cttctgtct  cacctgagc  tggttgcct  ccacattgt  cggctcacc  ttcatctca  180
catcagtgg  atggtccac  tcaaataca  gtgtggcat  tggttgcca  agcaatatc  240
caagccttg  tgacctccc  ttttcccag  tcaaaggag  atttgtcct  gcggtccaa  300
ctggagtca  actttgtgc  atctagcag  cagccagtg  agtggacaa  gactcggtc  360
cccctcgtg  cgaatt  376



<210> 6882
<211> 2156
<212> DNA
<213> Homo sapiens
<308> M88279
<400> 6882

cccggcctc  cgcacgccc  gcaggtagc  cccccgccc  cggcccaga  tgcgctcgc  60
ccggcacca  ctcccggat  aacggcgcg  cgcgcggag  tgacagccg  ggagatgaa  120
gcgaccgag  gcggggcgc  gtcggcgcc  ctgcccatg  agggagtgg  catcagccc  180
aaacaggac  aaggcgtgc  gaaggtcat  aagagagag  gcacaggta  agagatgcc  240
atgattggg  accgagtct  tgtccacta  actggctgg  tattagatg  cacaaagtt  300
gactccagt  tggatcgca  ggacaaatt  tcctttgac  tgggaaaag  ggaggtcat  360
aaggcttgg  acattgcca  agccaccat  aaggtgggg  aggtgtgcc  catcacctg  420
aaaccagaa  atgcctacg  ttcagcagg  agtcctcca  agattcccc  caatgccac  480
cttgtattt  aggtggagt  gtttgagtt  aagggagaa  atctgacgg  agaggaaga  540
ggcggaatc  ttcgcagaa  acagactcg  ggtgaaggc  atgctaagc  caatgaggg  600
gctatcgtg  aggttgcac  ggaagggta  tacaaggac  agctctttg  ccagcggga  660
ctccgcttt  agattggcg  gggggagaa  ctggatctg  cttatggtc  ggagagggc  720
attcagcgc  tggagaaag  agaacattc  atcgtgtac  tcaagccca  ctatgcttt  780
ggcagtgtt  ggaaggaaa  gttccaaat  ccaccaaat  ctgagctga  atatgaatt  840
cacctcaag  gttttgaaa  ggccaagga  tcttgggag  tgaattcag  agagaagct  900
gaacagagc  ccatagtga  agagcgggg  actgtgtac  tcaaggaag  taaatacaa  960
caagcttta  tacagtata  gaagatcgt  tcttggctg  aatatgagt  tagtttttc  1020
aatgaggaa  cacagaaag  acaggccct  cgactggcc  ctcacctca  cctggccat  1080
tgtcatctg  aactacagg  cttctctgc  gccattgaa  gctgtaaca  ggccctaga  1140
ctggacagc  acaacgaga  gggcctctt  cgccgggga  aggcccacc  ggccgtgaa  1200
gactttgaa  tggcacggg  tgatttcca  aaggtcctg  agctctacc  caacaacaa  1260
gccgccaag  cccagctgg  tgtgtgcca  cagcggatc  gaaggcagc  tgcccggga  1320
aagaagctc  atgccaata  gtttgagag  ctggctgag  aggagaaca  ggccaaggc  1380
gaggcttcc  caggagacc  tcccactga  acagagatg  aggaggagc  gaagagcaa  1440
acggcaggg  gccagtctc  ggtggagac  gaagcatag  ccctctcca  cagccctac  1500
cctgcggct  cctgccccc  agtctcccc  ctccaccct  ttagttttg  aaaaactga  1560
gaattttga  tgaattaga  ctttatttt  ctatctggt  ggatggtgg  tttagggga  1620
gggggaaag  tgtaggctg  gggattgag  tggggaatc  ttttagctg  tgtcagccc  1680
tcttccctt  ctccattgc  catgaacat  tgtccatcc  tatatattc  tcagaatgt  1740
aatttattt  gctccctct  ttaggtcca  tttctaagg  tagaagagg  aagtggtag  1800
gatgaggtc  gataagaac  cagggtgga  agggagact  ctgggcagc  gttttcctc  1860
tcctttccc  ctcccagtc  atttccaaa  gtggcctcc  tgtgggtgc  agggacatg  1920
gaaaaacca  tgctatgcc  tttcttctc  ctgttccct  cctcacccc  gacggtgtg  1980
ctgatgatg  cttctggtg  catggtgac  accccctgt  ccctgttct  gtatttccc  2040
tgtcagttt  ccctctcgg  caggttgtg  cccaaaatc  cctcagcct  ttctctgca  2100
gttgctgaa  gtccaggct  gcctcaagt  ccatgcttg  gcaataaag  ggaaac  2156



<210> 6883
<211> 458
<212> PRT
<213> Homo sapiens
<308> Q02790
<400> 6883

Thr Ala Glu Glu Met Lys Ala Thr Glu Ser Gly Ala Gln Ser Ala Pro 
  1               5                  10                  15
Leu Pro Met Glu Gly Val Asp Ile Ser Pro Lys Gln Asp Glu Gly Val 
             20                  25                  30
Leu Lys Val Ile Lys Arg Glu Gly Thr Gly Thr Glu Met Pro Met Ile 
         35                  40                  45
Gly Asp Arg Val Phe Val His Tyr Thr Gly Trp Leu Leu Asp Gly Thr 
     50                  55                  60
Lys Phe Asp Ser Ser Leu Asp Arg Lys Asp Lys Phe Ser Phe Asp Leu 
 65                  70                  75                  80
Gly Lys Gly Glu Val Ile Lys Ala Trp Asp Ile Ala Ile Ala Thr Met 
                 85                  90                  95
Lys Val Gly Glu Val Cys His Ile Thr Cys Lys Pro Glu Tyr Ala Tyr 
             100                105                110
Gly Ser Ala Gly Ser Pro Pro Lys Ile Pro Pro Asn Ala Thr Leu Val 
         115                120                125
Phe Glu Val Glu Leu Phe Glu Phe Lys Gly Glu Asp Leu Thr Glu Glu 
     130                135                140
Glu Asp Gly Gly Ile Ile Arg Arg Ile Gln Thr Arg Gly Glu Gly Tyr 
 145                150                155                160
Ala Lys Pro Asn Glu Gly Ala Ile Val Glu Val Ala Leu Glu Gly Tyr 
                 165                170                175
Tyr Lys Asp Lys Leu Phe Asp Gln Arg Glu Leu Arg Phe Glu Ile Gly 
             180                185                190
Glu Gly Glu Asn Leu Asp Leu Pro Tyr Gly Leu Glu Arg Ala Ile Gln 
         195                200                205
Arg Met Glu Lys Gly Glu His Ser Ile Val Tyr Leu Lys Pro Ser Tyr 
     210                215                220
Ala Phe Gly Ser Val Gly Lys Glu Lys Phe Gln Ile Pro Pro Asn Ala 
 225                230                235                240
Glu Leu Lys Tyr Glu Leu His Leu Lys Ser Phe Glu Lys Ala Lys Glu 
                 245                250                255
Ser Trp Glu Met Asn Ser Glu Glu Lys Leu Glu Gln Ser Thr Ile Val 
             260                265                270
Lys Glu Arg Gly Thr Val Tyr Phe Lys Glu Gly Lys Tyr Lys Gln Ala 
         275                280                285
Leu Leu Gln Tyr Lys Lys Ile Val Ser Trp Leu Glu Tyr Glu Ser Ser 
     290                295                300
Phe Ser Asn Glu Glu Ala Gln Lys Ala Gln Ala Leu Arg Leu Ala Ser 
 305                310                315                320
His Leu Asn Leu Ala Met Cys His Leu Lys Leu Gln Ala Phe Ser Ala 
                 325                330                335
Ala Ile Glu Ser Cys Asn Lys Ala Leu Glu Leu Asp Ser Asn Asn Glu 
             340                345                350
Lys Gly Leu Phe Arg Arg Gly Glu Ala His Leu Ala Val Asn Asp Phe 
         355                360                365
Glu Leu Ala Arg Ala Asp Phe Gln Lys Val Leu Gln Leu Tyr Pro Asn 
     370                375                380
Asn Lys Ala Ala Lys Thr Gln Leu Ala Val Cys Gln Gln Arg Ile Arg 
 385                390                395                400
Arg Gln Leu Ala Arg Glu Lys Lys Leu Tyr Ala Asn Met Phe Glu Arg 
                 405                410                415
Leu Ala Glu Glu Glu Asn Lys Ala Lys Ala Glu Ala Ser Ser Gly Asp 
             420                425                430
His Pro Thr Asp Thr Glu Met Lys Glu Glu Gln Lys Ser Asn Thr Ala 
         435                440                445
Gly Ser Gln Ser Gln Val Glu Thr Glu Ala 
     450                455



<210> 6884
<211> 376
<212> DNA
<213> Rattus norvegicus
<308> AI136977
<400> 6884

ttttttttt  tttttttaa  tcactcaaa  ttcttcagt  tttacaaaa  taacagggt  60
gagtaggga  gggagcagg  aggcagccg  aggggtggg  aggcggaga  gcaggctat  120
cttctgtct  cacctgagc  tggttgcct  ccacattgt  cggctcacc  ttcatctca  180
catcagtgg  atggtccac  tcaaataca  gtgtggcat  tggttgcca  agcaatatc  240
caagccttg  tgacctccc  ttttcccag  tcaaaggag  atttgtcct  gcggtccaa  300
ctggagtca  actttgtgc  atctagcag  cagccagtg  agtggacaa  gactcggtc  360
cccctcgtg  cgaatt  376



<210> 6885
<211> 2156
<212> DNA
<213> Homo sapiens
<308> M88279
<400> 6885

cccggcctc  cgcacgccc  gcaggtagc  cccccgccc  cggcccaga  tgcgctcgc  60
ccggcacca  ctcccggat  aacggcgcg  cgcgcggag  tgacagccg  ggagatgaa  120
gcgaccgag  gcggggcgc  gtcggcgcc  ctgcccatg  agggagtgg  catcagccc  180
aaacaggac  aaggcgtgc  gaaggtcat  aagagagag  gcacaggta  agagatgcc  240
atgattggg  accgagtct  tgtccacta  actggctgg  tattagatg  cacaaagtt  300
gactccagt  tggatcgca  ggacaaatt  tcctttgac  tgggaaaag  ggaggtcat  360
aaggcttgg  acattgcca  agccaccat  aaggtgggg  aggtgtgcc  catcacctg  420
aaaccagaa  atgcctacg  ttcagcagg  agtcctcca  agattcccc  caatgccac  480
cttgtattt  aggtggagt  gtttgagtt  aagggagaa  atctgacgg  agaggaaga  540
ggcggaatc  ttcgcagaa  acagactcg  ggtgaaggc  atgctaagc  caatgaggg  600
gctatcgtg  aggttgcac  ggaagggta  tacaaggac  agctctttg  ccagcggga  660
ctccgcttt  agattggcg  gggggagaa  ctggatctg  cttatggtc  ggagagggc  720
attcagcgc  tggagaaag  agaacattc  atcgtgtac  tcaagccca  ctatgcttt  780
ggcagtgtt  ggaaggaaa  gttccaaat  ccaccaaat  ctgagctga  atatgaatt  840
cacctcaag  gttttgaaa  ggccaagga  tcttgggag  tgaattcag  agagaagct  900
gaacagagc  ccatagtga  agagcgggg  actgtgtac  tcaaggaag  taaatacaa  960
caagcttta  tacagtata  gaagatcgt  tcttggctg  aatatgagt  tagtttttc  1020
aatgaggaa  cacagaaag  acaggccct  cgactggcc  ctcacctca  cctggccat  1080
tgtcatctg  aactacagg  cttctctgc  gccattgaa  gctgtaaca  ggccctaga  1140
ctggacagc  acaacgaga  gggcctctt  cgccgggga  aggcccacc  ggccgtgaa  1200
gactttgaa  tggcacggg  tgatttcca  aaggtcctg  agctctacc  caacaacaa  1260
gccgccaag  cccagctgg  tgtgtgcca  cagcggatc  gaaggcagc  tgcccggga  1320
aagaagctc  atgccaata  gtttgagag  ctggctgag  aggagaaca  ggccaaggc  1380
gaggcttcc  caggagacc  tcccactga  acagagatg  aggaggagc  gaagagcaa  1440
acggcaggg  gccagtctc  ggtggagac  gaagcatag  ccctctcca  cagccctac  1500
cctgcggct  cctgccccc  agtctcccc  ctccaccct  ttagttttg  aaaaactga  1560
gaattttga  tgaattaga  ctttatttt  ctatctggt  ggatggtgg  tttagggga  1620
gggggaaag  tgtaggctg  gggattgag  tggggaatc  ttttagctg  tgtcagccc  1680
tcttccctt  ctccattgc  catgaacat  tgtccatcc  tatatattc  tcagaatgt  1740
aatttattt  gctccctct  ttaggtcca  tttctaagg  tagaagagg  aagtggtag  1800
gatgaggtc  gataagaac  cagggtgga  agggagact  ctgggcagc  gttttcctc  1860
tcctttccc  ctcccagtc  atttccaaa  gtggcctcc  tgtgggtgc  agggacatg  1920
gaaaaacca  tgctatgcc  tttcttctc  ctgttccct  cctcacccc  gacggtgtg  1980
ctgatgatg  cttctggtg  catggtgac  accccctgt  ccctgttct  gtatttccc  2040
tgtcagttt  ccctctcgg  caggttgtg  cccaaaatc  cctcagcct  ttctctgca  2100
gttgctgaa  gtccaggct  gcctcaagt  ccatgcttg  gcaataaag  ggaaac  2156



<210> 6886
<211> 458
<212> PRT
<213> Homo sapiens
<308> Q02790
<400> 6886

Thr Ala Glu Glu Met Lys Ala Thr Glu Ser Gly Ala Gln Ser Ala Pro 
  1               5                  10                  15
Leu Pro Met Glu Gly Val Asp Ile Ser Pro Lys Gln Asp Glu Gly Val 
             20                  25                  30
Leu Lys Val Ile Lys Arg Glu Gly Thr Gly Thr Glu Met Pro Met Ile 
         35                  40                  45
Gly Asp Arg Val Phe Val His Tyr Thr Gly Trp Leu Leu Asp Gly Thr 
     50                  55                  60
Lys Phe Asp Ser Ser Leu Asp Arg Lys Asp Lys Phe Ser Phe Asp Leu 
 65                  70                  75                  80
Gly Lys Gly Glu Val Ile Lys Ala Trp Asp Ile Ala Ile Ala Thr Met 
                 85                  90                  95
Lys Val Gly Glu Val Cys His Ile Thr Cys Lys Pro Glu Tyr Ala Tyr 
             100                105                110
Gly Ser Ala Gly Ser Pro Pro Lys Ile Pro Pro Asn Ala Thr Leu Val 
         115                120                125
Phe Glu Val Glu Leu Phe Glu Phe Lys Gly Glu Asp Leu Thr Glu Glu 
     130                135                140
Glu Asp Gly Gly Ile Ile Arg Arg Ile Gln Thr Arg Gly Glu Gly Tyr 
 145                150                155                160
Ala Lys Pro Asn Glu Gly Ala Ile Val Glu Val Ala Leu Glu Gly Tyr 
                 165                170                175
Tyr Lys Asp Lys Leu Phe Asp Gln Arg Glu Leu Arg Phe Glu Ile Gly 
             180                185                190
Glu Gly Glu Asn Leu Asp Leu Pro Tyr Gly Leu Glu Arg Ala Ile Gln 
         195                200                205
Arg Met Glu Lys Gly Glu His Ser Ile Val Tyr Leu Lys Pro Ser Tyr 
     210                215                220
Ala Phe Gly Ser Val Gly Lys Glu Lys Phe Gln Ile Pro Pro Asn Ala 
 225                230                235                240
Glu Leu Lys Tyr Glu Leu His Leu Lys Ser Phe Glu Lys Ala Lys Glu 
                 245                250                255
Ser Trp Glu Met Asn Ser Glu Glu Lys Leu Glu Gln Ser Thr Ile Val 
             260                265                270
Lys Glu Arg Gly Thr Val Tyr Phe Lys Glu Gly Lys Tyr Lys Gln Ala 
         275                280                285
Leu Leu Gln Tyr Lys Lys Ile Val Ser Trp Leu Glu Tyr Glu Ser Ser 
     290                295                300
Phe Ser Asn Glu Glu Ala Gln Lys Ala Gln Ala Leu Arg Leu Ala Ser 
 305                310                315                320
His Leu Asn Leu Ala Met Cys His Leu Lys Leu Gln Ala Phe Ser Ala 
                 325                330                335
Ala Ile Glu Ser Cys Asn Lys Ala Leu Glu Leu Asp Ser Asn Asn Glu 
             340                345                350
Lys Gly Leu Phe Arg Arg Gly Glu Ala His Leu Ala Val Asn Asp Phe 
         355                360                365
Glu Leu Ala Arg Ala Asp Phe Gln Lys Val Leu Gln Leu Tyr Pro Asn 
     370                375                380
Asn Lys Ala Ala Lys Thr Gln Leu Ala Val Cys Gln Gln Arg Ile Arg 
 385                390                395                400
Arg Gln Leu Ala Arg Glu Lys Lys Leu Tyr Ala Asn Met Phe Glu Arg 
                 405                410                415
Leu Ala Glu Glu Glu Asn Lys Ala Lys Ala Glu Ala Ser Ser Gly Asp 
             420                425                430
His Pro Thr Asp Thr Glu Met Lys Glu Glu Gln Lys Ser Asn Thr Ala 
         435                440                445
Gly Ser Gln Ser Gln Val Glu Thr Glu Ala 
     450                455



<210> 6887
<211> 376
<212> DNA
<213> Rattus norvegicus
<308> AI136977
<400> 6887

ttttttttt  tttttttaa  tcactcaaa  ttcttcagt  tttacaaaa  taacagggt  60
gagtaggga  gggagcagg  aggcagccg  aggggtggg  aggcggaga  gcaggctat  120
cttctgtct  cacctgagc  tggttgcct  ccacattgt  cggctcacc  ttcatctca  180
catcagtgg  atggtccac  tcaaataca  gtgtggcat  tggttgcca  agcaatatc  240
caagccttg  tgacctccc  ttttcccag  tcaaaggag  atttgtcct  gcggtccaa  300
ctggagtca  actttgtgc  atctagcag  cagccagtg  agtggacaa  gactcggtc  360
cccctcgtg  cgaatt  376



<210> 6888
<211> 2156
<212> DNA
<213> Homo sapiens
<308> M88279
<400> 6888

cccggcctc  cgcacgccc  gcaggtagc  cccccgccc  cggcccaga  tgcgctcgc  60
ccggcacca  ctcccggat  aacggcgcg  cgcgcggag  tgacagccg  ggagatgaa  120
gcgaccgag  gcggggcgc  gtcggcgcc  ctgcccatg  agggagtgg  catcagccc  180
aaacaggac  aaggcgtgc  gaaggtcat  aagagagag  gcacaggta  agagatgcc  240
atgattggg  accgagtct  tgtccacta  actggctgg  tattagatg  cacaaagtt  300
gactccagt  tggatcgca  ggacaaatt  tcctttgac  tgggaaaag  ggaggtcat  360
aaggcttgg  acattgcca  agccaccat  aaggtgggg  aggtgtgcc  catcacctg  420
aaaccagaa  atgcctacg  ttcagcagg  agtcctcca  agattcccc  caatgccac  480
cttgtattt  aggtggagt  gtttgagtt  aagggagaa  atctgacgg  agaggaaga  540
ggcggaatc  ttcgcagaa  acagactcg  ggtgaaggc  atgctaagc  caatgaggg  600
gctatcgtg  aggttgcac  ggaagggta  tacaaggac  agctctttg  ccagcggga  660
ctccgcttt  agattggcg  gggggagaa  ctggatctg  cttatggtc  ggagagggc  720
attcagcgc  tggagaaag  agaacattc  atcgtgtac  tcaagccca  ctatgcttt  780
ggcagtgtt  ggaaggaaa  gttccaaat  ccaccaaat  ctgagctga  atatgaatt  840
cacctcaag  gttttgaaa  ggccaagga  tcttgggag  tgaattcag  agagaagct  900
gaacagagc  ccatagtga  agagcgggg  actgtgtac  tcaaggaag  taaatacaa  960
caagcttta  tacagtata  gaagatcgt  tcttggctg  aatatgagt  tagtttttc  1020
aatgaggaa  cacagaaag  acaggccct  cgactggcc  ctcacctca  cctggccat  1080
tgtcatctg  aactacagg  cttctctgc  gccattgaa  gctgtaaca  ggccctaga  1140
ctggacagc  acaacgaga  gggcctctt  cgccgggga  aggcccacc  ggccgtgaa  1200
gactttgaa  tggcacggg  tgatttcca  aaggtcctg  agctctacc  caacaacaa  1260
gccgccaag  cccagctgg  tgtgtgcca  cagcggatc  gaaggcagc  tgcccggga  1320
aagaagctc  atgccaata  gtttgagag  ctggctgag  aggagaaca  ggccaaggc  1380
gaggcttcc  caggagacc  tcccactga  acagagatg  aggaggagc  gaagagcaa  1440
acggcaggg  gccagtctc  ggtggagac  gaagcatag  ccctctcca  cagccctac  1500
cctgcggct  cctgccccc  agtctcccc  ctccaccct  ttagttttg  aaaaactga  1560
gaattttga  tgaattaga  ctttatttt  ctatctggt  ggatggtgg  tttagggga  1620
gggggaaag  tgtaggctg  gggattgag  tggggaatc  ttttagctg  tgtcagccc  1680
tcttccctt  ctccattgc  catgaacat  tgtccatcc  tatatattc  tcagaatgt  1740
aatttattt  gctccctct  ttaggtcca  tttctaagg  tagaagagg  aagtggtag  1800
gatgaggtc  gataagaac  cagggtgga  agggagact  ctgggcagc  gttttcctc  1860
tcctttccc  ctcccagtc  atttccaaa  gtggcctcc  tgtgggtgc  agggacatg  1920
gaaaaacca  tgctatgcc  tttcttctc  ctgttccct  cctcacccc  gacggtgtg  1980
ctgatgatg  cttctggtg  catggtgac  accccctgt  ccctgttct  gtatttccc  2040
tgtcagttt  ccctctcgg  caggttgtg  cccaaaatc  cctcagcct  ttctctgca  2100
gttgctgaa  gtccaggct  gcctcaagt  ccatgcttg  gcaataaag  ggaaac  2156



<210> 6889
<211> 458
<212> PRT
<213> Homo sapiens
<308> Q02790
<400> 6889

Thr Ala Glu Glu Met Lys Ala Thr Glu Ser Gly Ala Gln Ser Ala Pro 
  1               5                  10                  15
Leu Pro Met Glu Gly Val Asp Ile Ser Pro Lys Gln Asp Glu Gly Val 
             20                  25                  30
Leu Lys Val Ile Lys Arg Glu Gly Thr Gly Thr Glu Met Pro Met Ile 
         35                  40                  45
Gly Asp Arg Val Phe Val His Tyr Thr Gly Trp Leu Leu Asp Gly Thr 
     50                  55                  60
Lys Phe Asp Ser Ser Leu Asp Arg Lys Asp Lys Phe Ser Phe Asp Leu 
 65                  70                  75                  80
Gly Lys Gly Glu Val Ile Lys Ala Trp Asp Ile Ala Ile Ala Thr Met 
                 85                  90                  95
Lys Val Gly Glu Val Cys His Ile Thr Cys Lys Pro Glu Tyr Ala Tyr 
             100                105                110
Gly Ser Ala Gly Ser Pro Pro Lys Ile Pro Pro Asn Ala Thr Leu Val 
         115                120                125
Phe Glu Val Glu Leu Phe Glu Phe Lys Gly Glu Asp Leu Thr Glu Glu 
     130                135                140
Glu Asp Gly Gly Ile Ile Arg Arg Ile Gln Thr Arg Gly Glu Gly Tyr 
 145                150                155                160
Ala Lys Pro Asn Glu Gly Ala Ile Val Glu Val Ala Leu Glu Gly Tyr 
                 165                170                175
Tyr Lys Asp Lys Leu Phe Asp Gln Arg Glu Leu Arg Phe Glu Ile Gly 
             180                185                190
Glu Gly Glu Asn Leu Asp Leu Pro Tyr Gly Leu Glu Arg Ala Ile Gln 
         195                200                205
Arg Met Glu Lys Gly Glu His Ser Ile Val Tyr Leu Lys Pro Ser Tyr 
     210                215                220
Ala Phe Gly Ser Val Gly Lys Glu Lys Phe Gln Ile Pro Pro Asn Ala 
 225                230                235                240
Glu Leu Lys Tyr Glu Leu His Leu Lys Ser Phe Glu Lys Ala Lys Glu 
                 245                250                255
Ser Trp Glu Met Asn Ser Glu Glu Lys Leu Glu Gln Ser Thr Ile Val 
             260                265                270
Lys Glu Arg Gly Thr Val Tyr Phe Lys Glu Gly Lys Tyr Lys Gln Ala 
         275                280                285
Leu Leu Gln Tyr Lys Lys Ile Val Ser Trp Leu Glu Tyr Glu Ser Ser 
     290                295                300
Phe Ser Asn Glu Glu Ala Gln Lys Ala Gln Ala Leu Arg Leu Ala Ser 
 305                310                315                320
His Leu Asn Leu Ala Met Cys His Leu Lys Leu Gln Ala Phe Ser Ala 
                 325                330                335
Ala Ile Glu Ser Cys Asn Lys Ala Leu Glu Leu Asp Ser Asn Asn Glu 
             340                345                350
Lys Gly Leu Phe Arg Arg Gly Glu Ala His Leu Ala Val Asn Asp Phe 
         355                360                365
Glu Leu Ala Arg Ala Asp Phe Gln Lys Val Leu Gln Leu Tyr Pro Asn 
     370                375                380
Asn Lys Ala Ala Lys Thr Gln Leu Ala Val Cys Gln Gln Arg Ile Arg 
 385                390                395                400
Arg Gln Leu Ala Arg Glu Lys Lys Leu Tyr Ala Asn Met Phe Glu Arg 
                 405                410                415
Leu Ala Glu Glu Glu Asn Lys Ala Lys Ala Glu Ala Ser Ser Gly Asp 
             420                425                430
His Pro Thr Asp Thr Glu Met Lys Glu Glu Gln Lys Ser Asn Thr Ala 
         435                440                445
Gly Ser Gln Ser Gln Val Glu Thr Glu Ala 
     450                455



<210> 6890
<211> 590
<212> DNA
<213> Rattus norvegicus
<308> AI137790
<400> 6890

ttttttttt  tttttttct  tgtgcacac  gctttattg  atatcgctg  agcgtcccc  60
agtggctct  attactggt  tgacaggag  aggtggtgc  tcactggag  tacagacaa  120
gatggctga  attanatga  tggggtggg  gcccagcac  tanggagag  gtattacca  180
ctagtcacg  acactctct  cactgccct  atggagaga  aacagccag  ccccgtcac  240
gcagcagag  gagcggagc  ctcttcagc  ctggggagc  agcctggag  tttgccatt  300
cctgctgtt  caaggtcca  caggactgg  gcaggatct  ccctcaagt  cagccagcc  360
gtggggtca  ctgcaaagt  ccagtgcct  caggatggt  tcttgccag  ggtggcccc  420
gtcttcttt  atgctccct  cagcagcgc  agcttctta  gcaggctgg  gctggcctt  480
atcaccaca  catgctcaa  cttcttccg  attcctact  ccaggctct  cttcaactt  540
tgctgctgc  caacgcgcg  cttcttggg  gcgatgact  gaccgccttt  590



<210> 6891
<211> 93
<212> PRT
<213> Rattus norvegicus
<308> Q05310
<400> 6891

Met Ala Gln Gly Gln Arg Lys Phe Gln Ala Gln Lys Pro Lys Ser Lys 
  1               5                  10                  15
Ala Ala Ala Ala Glu Arg Ser Arg Gly Pro Arg Lys Gly Gly Arg Val 
             20                  25                  30
Ile Gly Pro Lys Lys Ala Arg Val Val Gln Gln Gln Lys Leu Lys Lys 
         35                  40                  45
Ser Leu Glu Val Gly Ile Arg Lys Lys Ile Glu His Asp Val Val Met 
     50                  55                  60
Lys Ala Ser Ser Ser Leu Pro Lys Lys Leu Ala Leu Leu Lys Gly Ala 
 65                  70                  75                  80
Ser Lys Lys Thr Gly Ala Thr Pro Gly Lys Thr Pro Ser 
                 85                  90



<210> 6892
<211> 616
<212> DNA
<213> Homo sapiens
<308> NM_014047
<400> 6892

gaccggacc  tggcgcagg  gcagcgcaa  tttcaggcg  acaaacccg  aaagagtaa  60
acggcagcg  cagcctctg  aaagaatcg  ggcccaaga  aaggcggtc  tgttatcgc  120
cccaagaag  cgcgcgtcg  gcagcagca  aagctcaag  agaacctag  agtcggaat  180
cggaagaag  tcgaacatg  cgtggtgat  aaagccagc  gcagcctgc  caagaagct  240
gcactgctg  aggccccag  caagaagaa  ggggcagct  ccgccacct  ctccaagac  300
ccttcctga  gacgctggc  ccagtgcag  ccaacatcc  accccctac  tccatatgg  360
accttgcaa  tcatcccac  ggctgcact  tcaggaaga  gaccctgtc  cccagcact  420
ggcttcacc  agaacttca  tgggggcca  gggtgctga  aacccagca  tgaccagga  480
gatacagtc  ctaacttca  ctgtccccg  gccccttcc  aggtcctgc  tccacaggt  540
taacccaga  caataaacc  ggctttgtc  gtaaaaaaa  aaaaaaaaa  aaaaaaaaa  600
aaaaaaaaa  aaaaaa  616



<210> 6893
<211> 99
<212> PRT
<213> Homo sapiens
<308> AAD44484
<400> 6893

Met Ala Gln Gly Gln Arg Lys Phe Gln Ala His Lys Pro Ala Lys Ser 
  1               5                  10                  15
Lys Thr Ala Ala Ala Ala Ser Glu Lys Asn Arg Gly Pro Arg Lys Gly 
             20                  25                  30
Gly Arg Val Ile Ala Pro Lys Lys Ala Arg Val Val Gln Gln Gln Lys 
         35                  40                  45
Leu Lys Lys Asn Leu Glu Val Gly Ile Arg Lys Lys Ile Glu His Asp 
     50                  55                  60
Val Val Met Lys Ala Ser Ser Ser Leu Pro Lys Lys Leu Ala Leu Leu 
 65                  70                  75                  80
Lys Ala Pro Ala Lys Lys Lys Gly Ala Ala Ala Ala Thr Ser Ser Lys 
                 85                  90                  95
Thr Pro Ser 
             100



<210> 6894
<211> 475
<212> DNA
<213> Rattus norvegicus
<308> AI144767
<400> 6894

ttttttttt  tttttctga  cacttttta  atagattta  ttctacggc  cgcaaatgg  60
tatatgaac  catctcatg  acacttcat  agggacatt  tcttagtct  tttaacagc  120
tgacacgat  atcagattc  aacaccgtt  aacttaaca  agcatacct  tcaaccagg  180
acttgtggt  cgagctcct  ttttcaaaa  ctattttgc  caagcatag  tacacgttg  240
atcacattt  aaacactat  catgttagg  ggatgttag  aatacaaat  tagaagaga  300
atttaaagc  ggactcaca  ctgtttaga  gaaatagaa  attttttcc  ttttttggg  360
ggatggtgg  ggtggggga  tcctcatta  caatcactt  atagagggc  tgctgatgc  420
cgaagagct  aattgattg  tataaatat  ttcccatat  cataatgta  cataa  475



<210> 6895
<211> 284
<212> PRT
<213> Rattus norvegicus
<308> Q63582
<400> 6895

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
  1               5                  10                  15
Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
             20                  25                  30
Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
         35                  40                  45
Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
     50                  55                  60
Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
 65                  70                  75                  80
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                 85                  90                  95
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
             100                105                110
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
         115                120                125
Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
     130                135                140
Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
 145                150                155                160
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                 165                170                175
Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
             180                185                190
Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
         195                200                205
Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu 
     210                215                220
Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
 225                230                235                240
Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                 245                250                255
Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
             260                265                270
Glu Leu Asp His Ala Leu Lys Asp Met Thr Ser Ile 
         275                280



<210> 6896
<211> 2301
<212> DNA
<213> Homo sapiens
<308> X03541
<400> 6896

gtcgaccgg  gggcaggag  agcaggagg  gcaggagca  gaggagcag  aggagcagg  60
ggagcagga  gagcaggag  agcaggaac  ggaggagga  gaggaggag  aggaggagc  120
ggaagagca  gaggaggag  agcaggagc  ggaggagca  gagggagag  aggctgcaa  180
gccgagcgg  ggaggcagg  accggagcg  gagcagtag  tgggtgggc  ccatggctg  240
gatcaccac  atcgaggcg  tgaagcgca  gatccaggt  ctgcagcag  aggcagatg  300
tgcagagga  cgagctgag  gcctccagc  agaagttga  ggagaaagg  gggcccggg  360
acaggctga  gctgaggtg  cctccttga  ccgtaggat  cagctggtt  aagaagagc  420
ggaccgtgc  caggagcgc  tggccactg  cctgcaaaa  ctggaagaa  ctgaaaaag  480
tgctgatga  agtgagaga  gtatgaagg  tattgaaaa  cgggcctta  aagatgaag  540
aaagatgga  ctccaggaa  tccaactcg  agaagctaa  cacattgca  aagaggcag  600
taggaagta  gaagaggtg  ctcgtaagt  ggtgatcat  gaaggagac  tggaacgca  660
agaggaacg  gctgagctg  cagagtcgc  ttgccgaga  atggatgag  agattagac  720
gatggacca  aacctgaag  gtctgagtg  tgccgaaga  aagtactct  aaaaagaag  780
taaatatga  gaagaaatc  agattctta  tgataaact  aaggaggca  agacccgtg  840
tgagtttgc  gagagatcg  tagccaagc  ggaaaagac  attgatgac  tggaagaca  900
taacagcac  tctggagac  cggtggaga  gaaggacga  acacctttt  gggtctcgg  960
ggctgtggg  ctggccgtc  ttgcctgcc  cttcctttc  acgctgctc  ttgtgctca  1020
caaatgtgg  cggagaaac  agtttggga  caaccgccc  gctgtgctg  ctccagagg  1080
tgggctggc  atgtccctg  atttcatga  attgggtgg  agctccctg  cccccaccg  1140
gggcaaagg  tctgggctc  aaggccaca  catcgagaa  ccacaatac  tcagtgatg  1200
ctgtgttca  cacatcaag  gccgggaca  cgtgctcaa  tgggagctg  gggagggcg  1260
ctttgggaa  gtcttcctt  ctgagtgcc  caacctcct  cctgagcag  acaagatgc  1320
ggtggctgt  aaggcactg  aggaggcgt  cgagagtgc  cggcaggac  tccaacgtg  1380
ggctgagct  ctcaccatg  tgcagcacc  gcacatcgt  cgcttcttc  gcgtctgca  1440
cgagggccg  cccctgctc  tggtcttcg  gtatatgcg  cacggggac  tcaaccgct  1500
cctccgatc  catggaccc  atgccaagc  gctggctgg  ggggaggat  tggctccag  1560
ccccctggg  ctggggcag  tgctggccg  ggctagcca  gtcgctgcg  ggatggtgt  1620
cctggcggg  ctgcatttt  tgcaccggg  cctggccac  cgcaactgt  tagtgggcc  1680
gggactggt  gtcaagatt  gtgattttg  catgagcag  gatatctac  gcaccgact  1740
ttaccgtgt  ggaggccgc  ccatgctgc  cattcgctg  atgccgccc  agagcatcc  1800
gtaccgtaa  ttcaccacc  agagcgacg  gtggagctt  ggcgtggtg  tctgggaga  1860
cttcaccta  ggcaagcag  cctggtacc  gctctccaa  acggaggca  tcgactgca  1920
cacgcaggg  cgtgagttg  agcggccac  tgcctgccc  ccagaggtc  acgccatca  1980
gcggggctg  tggcagcgg  agcccagca  cgccacagc  tcaaggatg  gcacgcccg  2040
ctgcaagcc  tggcctagg  acctcctgt  tacctggat  tcctgggct  gggggccgg  2100
ccaggggct  ggagtggtt  gccggaata  tggggcctg  cctcagcat  ccccatagc  2160
cccagcagc  ccagggtga  ctcgaagta  ctaattcgc  ctcagcatg  gggaaggga  2220
aggtggggg  tgggagtag  ggatgttcc  gcttctcta  gcaaggtcc  gtcgtagca  2280
ttatattta  tatgggaat  c  2301



<210> 6897
<211> 796
<212> PRT
<213> Homo sapiens
<308> P04629
<400> 6897

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
  1               5                  10                  15
Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
             20                  25                  30
Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
         35                  40                  45
Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
     50                  55                  60
Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
 65                  70                  75                  80
His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                 85                  90                  95
Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
             100                105                110
Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
         115                120                125
Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
     130                135                140
Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
 145                150                155                160
Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                 165                170                175
Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
             180                185                190
Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
         195                200                205
Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
     210                215                220
Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
 225                230                235                240
Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                 245                250                255
Asp Leu Asn Arg Lys Asn Leu Thr Cys Trp Ala Glu Asn Asp Val Gly 
             260                265                270
Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
         275                280                285
Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
     290                295                300
Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
 305                310                315                320
Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                 325                330                335
Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
             340                345                350
His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
         355                360                365
Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
     370                375                380
Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
 385                390                395                400
Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe 
                 405                410                415
Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu 
             420                425                430
Ser Thr Leu Leu Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe 
         435                440                445
Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met 
     450                455                460
Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu 
 465                470                475                480
Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr 
                 485                490                495
Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu 
             500                505                510
Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu 
         515                520                525
Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys 
     530                535                540
Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu 
 545                550                555                560
Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe 
                 565                570                575
Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met 
             580                585                590
Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala 
         595                600                605
Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu 
     610                615                620
Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr 
 625                630                635                640
Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys 
                 645                650                655
Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser 
             660                665                670
Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met 
         675                680                685
Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe 
     690                695                700
Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile 
 705                710                715                720
Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala 
                 725                730                735
Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys 
             740                745                750
Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro 
         755                760                765
Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu 
     770                775                780
Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
 785                790                795



<210> 6898
<211> 403
<212> DNA
<213> Rattus norvegicus
<308> AI146195
<400> 6898

cggccgctg  atcccggcg  tggcgagga  gggggcaca  agctggctg  gctgcgagg  60
aagaagact  gaagcatga  ttcagacag  agccaagcg  tgatcacca  ccctcctcc  120
cccagcatg  ctcacaaag  gaggtattt  gaccgaatc  atgaaagtg  tccagaata  180
cttcgagag  ggaacatgt  tcctgatct  cggcaggac  tcaatatga  ggagcagag  240
aagcgagtc  ctcagatcc  gcagagtcc  gcctttcgg  aagacctag  gtgcctcat  300
caagaacag  tgaagaaag  ccacgaccc  accggattg  tagcgttac  gcagatcgc  360
gactacatc  tggccaact  cttcaccgg  ttttcttca  ctc  403



<210> 6899
<211> 705
<212> PRT
<213> Rattus norvegicus
<308> Q62847
<400> 6899

Met Ser Ser Asp Ser Ser Gln Ala Val Ile Thr Thr Pro Pro Pro Pro 
  1               5                  10                  15
Ser Met Pro His Lys Glu Arg Tyr Phe Asp Arg Ile Asn Glu Ser Asp 
             20                  25                  30
Pro Glu Tyr Leu Arg Glu Arg Asn Met Ser Pro Asp Leu Arg Glu Asp 
         35                  40                  45
Phe Asn Met Met Glu Gln Arg Lys Arg Val Thr Gln Ile Leu Gln Ser 
     50                  55                  60
Pro Ala Phe Arg Glu Asp Leu Glu Cys Leu Thr Gln Glu Gln Met Lys 
 65                  70                  75                  80
Lys Gly His Asp Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp 
                 85                  90                  95
Tyr Ile Met Ala Asn Ser Phe Thr Gly Phe Ser Ser Pro Pro Leu Ser 
             100                105                110
Leu Gly Met Val Thr Pro Ile Asn Asp Leu Pro Gly Ala Asp Thr Ser 
         115                120                125
Ser Tyr Val Lys Gly Glu Lys Leu Thr Arg Cys Glu Leu Ala Ser Leu 
     130                135                140
Tyr Arg Leu Ala Asp Leu Phe Gly Trp Ala His Leu Ala Asn Thr Tyr 
 145                150                155                160
Ile Ser Val Arg Val Ser Lys Glu Gln Asp His Ile Ile Ile Ile Pro 
                 165                170                175
Arg Gly Leu Pro Phe Ser Glu Ala Thr Ala Ser Ala Leu Val Lys Val 
             180                185                190
Asn Ile Ile Gly Glu Val Val Asp Gln Gly Ser Thr Asn Leu Lys Ile 
         195                200                205
Asp His Ser Gly Phe Ser Pro His Ala Ala Ile Tyr Ser Thr Arg Pro 
     210                215                220
Asp Val Lys Cys Val Ile His Ile His Thr Leu Ala Thr Ala Ala Val 
 225                230                235                240
Ser Ser Met Lys Cys Gly Ile Leu Pro Ile Ser Gln Glu Ser Leu Ile 
                 245                250                255
Leu Gly Asp Val Ala Tyr Tyr Asp Tyr Gln Gly Ser Leu Asp Glu Glu 
             260                265                270
Glu Glu Arg Ile Glu Leu Gln Lys Val Leu Gly Pro Ser Cys Lys Val 
         275                280                285
Leu Val Leu Arg Asn His Gly Val Val Ala Leu Gly Glu Thr Leu Glu 
     290                295                300
Glu Ala Phe His Tyr Ile Phe Asn Val Gln Met Ala Cys Glu Ile Gln 
 305                310                315                320
Val Gln Ala Val Ala Gly Ala Gly Gly Val Asp Asn Leu Leu Ile Leu 
                 325                330                335
Asp Leu Gln Lys Tyr Lys Ala Phe Thr His Gly Val Ala Met Thr Gly 
             340                345                350
Gly Gly Gly Val Asn Met Gly Ser His Gln Lys Trp Lys Val Gly Glu 
         355                360                365
Ile Glu Phe Glu Gly Leu Met Arg Thr Leu Asp Asn Leu Gly Tyr Arg 
     370                375                380
Thr Gly Tyr Ala Tyr Arg His Pro Leu Val Arg Glu Lys Pro Arg His 
 385                390                395                400
Lys Ser Asp Val Glu Ile Pro Ala Thr Val Thr Ala Phe Ser Phe Glu 
                 405                410                415
Asp Asp Ser Val Pro Leu Ser Pro Leu Lys Tyr Met Ala Gln Arg Gln 
             420                425                430
Gln Arg Glu Lys Thr Arg Trp Leu Asn Ser Pro Asn Thr Tyr Met Lys 
         435                440                445
Val Asn Val Pro Glu Glu Ser Arg Asn Gly Glu Thr Ser Pro Arg Thr 
     450                455                460
Lys Ile Thr Trp Met Lys Ala Glu Asp Pro Ser Lys Val Ser Ser Gly 
 465                470                475                480
Thr Pro Ile Lys Ile Glu Asp Pro Asn Gln Phe Val Pro Leu Asn Thr 
                 485                490                495
Asn Pro Thr Glu Val Leu Glu Lys Arg Asn Lys Ile Arg Glu Gln Asn 
             500                505                510
Arg Tyr Asp Leu Lys Thr Ala Gly Pro Gln Ser Gln Leu Leu Ala Gly 
         515                520                525
Ile Val Val Asp Lys Pro Pro Ser Thr Met Arg Phe Glu Asp Asp Asp 
     530                535                540
Gln Gly Pro Pro Ala Pro Pro Asn Pro Phe Ser His Leu Met Glu Gly 
 545                550                555                560
Glu Leu Glu Glu Tyr Thr Lys Thr Ile Glu Arg Gln Gln Gln Gly Leu 
                 565                570                575
Asp Asp Ala Glu Gln Glu Ser Leu Ser Asp Asp Ala Ala Ser Val Ser 
             580                585                590
Gln Ile Gln Ser Gln Thr Gln Ser Pro Gln Ser Val Pro Glu Arg Leu 
         595                600                605
Glu Glu Asn His Glu Leu Phe Ser Lys Ser Phe Thr Ser Val Asp Val 
     610                615                620
Pro Val Ile Val Asn Gly Lys Asp Glu Met His Asp Val Glu Asp Glu 
 625                630                635                640
Leu Ala Gln Arg Val Ser Arg Leu Thr Thr Ser Thr Thr Ile Glu Asn 
                 645                650                655
Ile Glu Ile Thr Ile Lys Ser Pro Asp Arg Thr Glu Glu Val Leu Ser 
             660                665                670
Pro Asp Gly Ser Pro Ser Lys Ser Pro Ser Lys Lys Lys Lys Lys Phe 
         675                680                685
Arg Thr Pro Ser Phe Leu Lys Lys Asn Lys Lys Lys Glu Lys Val Glu 
     690                695                700
Ala 
 705



<210> 6900
<211> 2864
<212> DNA
<213> Homo sapiens
<308> NM_016824
<400> 6900

agataacaa  agtaatcca  agacttaaa  catgagctc  gatgccagc  aaggcgtga  60
taccactcc  cctcctccc  gcatgcctc  caaagagag  tattttgac  gcatcaatg  120
aaatgaccc  gaatacatt  gggagagga  catgtctcc  gatctacga  aagacttca  180
catgatgga  cagaggaaa  gagttactc  gatcctgca  agtcctgcc  ttcgggaag  240
cttggaatg  cttattcaa  aacagatga  gaaaggcca  aacccaact  gattactag  300
attacagca  attgcagat  acatcatgg  caattcttt  tcgggtttt  cttcacctc  360
tctcagtct  ggcatggtc  cacctatca  tgaccttcc  ggtgcagat  catcctcat  420
tgtgaaggg  gaaaaactt  ctcgctgta  acttgccag  ctgtacaga  ttgtagact  480
gtttggatg  gcacacctg  caaatacct  tatctcagt  agaataagt  aggagcaag  540
ccacattat  ataattccc  gaggcctat  tttttctga  gctacagcc  ccaatttgg  600
gaaagtcaa  ataatagga  aagtggttg  ccagggaag  accaatttg  aaattgacc  660
tacaggatt  agtccccat  ctgcaatct  ttcaacacg  cctgatgtt  agtgtgtca  720
acacatcca  acccttgca  cagcagctg  atcctccat  aaatgtggg  tccttccaa  780
ttctcaaga  tctcttctt  tgggagatg  tgcctatta  gactaccaa  ggtcacttg  840
agaacagga  gagagaatt  aactgcaga  ggttctggg  ccaagttgt  aggtgctgg  900
actcaggaa  catggtgtg  ttgcacttg  agaaacatt  gaggaggct  ttcattata  960
ttttaatgt  caactagcc  gtgagattc  ggtgcaggc  ctagcaggt  caggtggag  1020
agacaatct  catgtactg  actttcaga  gtataaagc  ttcacttac  ctgtagcag  1080
gtctggtgg  ggaggtgtg  atatgggtt  ccatcaaaa  tggaaggtt  gcgaaattg  1140
gtttgaagg  cttatgagg  ctctggaca  cttggggta  agaacaggc  atgcttaca  1200
gcatcctct  attcgagag  agcctaggc  caagagtga  gtggaaatc  cagcaactg  1260
gactgcttt  tcctttgaa  acgatacag  gccactctc  cctctcaaa  acatggcac  1320
gaggcaaca  cgtgaaaaa  caagatggc  gaactcacc  aatacttac  tgaaagtga  1380
tgtgcctga  gagtctcgg  acggagaaa  cagtccccg  accaaaatc  cgtggatga  1440
agcagaaga  tcatctaaa  ttagtggtg  aacacctat  aaaattgaa  atccaaatc  1500
gtttgttcc  ttaaacaca  acccgaatg  ggtactaga  aagagaaat  agattcggg  1560
acaaaatcg  tatgacttg  aaacagcag  accacaatc  cagttgctt  ctggaattg  1620
tgtggataa  ccaccttct  ctatgcaat  tgaagatga  gatcatggc  caccagctc  1680
tcctaaccc  tttagtcat  tcacagaag  agaacttga  gagtataag  ggacaatcg  1740
acgtaaaca  caaggccta  aagatgctg  gcaggaatt  ctctcagat  acgcttcat  1800
tgtttcaca  attcagtct  aaactcagt  accgcaaaa  gtccctgaa  aattagaag  1860
aaaccatga  ctgttttcc  agagcttca  ctccatgga  gtgcctgtc  tggtagtaa  1920
tggcaagga  gatatgcat  atgttgaag  tgagcttgc  aagcgagtg  gtaggttaa  1980
cacaagtac  accatagaa  acatcgaga  tactattaa  tctccagag  aaatcgaag  2040
agtcctgtc  cctgaaggc  ccccttcaa  atcgccatc  aagaaaaag  agaaattcc  2100
cactccttc  tttctgaaa  agaacaaaa  aaaggagaa  gttgaggcc  aaataaagt  2160
tttttataa  tattattat  acaatgtga  attgcacat  taaatacca  atttaagtt  2220
atcattaat  tgcaatggt  gatcagatt  ggggatgta  caaactgga  tttaagaac  2280
ggaaagagg  tttacaaaa  aaaaacttt  agattcatc  ctcatttta  atgtccaga  2340
atggctttg  attttaagc  attactagt  ttaattagc  ctgccctca  gaagtatta  2400
tataattca  cataaacag  tatctgtct  aattacttc  ggccttctc  ataatatct  2460
ttagaaaga  attgccagt  agcaagtga  aatttttat  tctcaatac  tgcttcact  2520
gataatcat  ttataattt  ttatcatga  tattgacta  atttttgga  tcccattgt  2580
tcagtgggc  ttaacagaa  gctttaaaa  cttctaaga  aagaatcta  agcattagt  2640
tacactggc  cataatttt  taaaaagtt  taagaaaag  ttcatttgg  attttattc  2700
cagtataaa  tttcctcac  tgaagtaac  ttgtttgcc  aaaaagttg  tttaataaa  2760
tataatttt  gaaaacttc  ttttttatt  gtttagaaa  ccccttatt  ttcaacaaa  2820
gggattttg  acacataac  tgggttatt  agtttaact  tggc  2864



<210> 6901
<211> 706
<212> PRT
<213> Homo sapiens
<308> Q9UEY8
<400> 6901

Met Ser Ser Asp Ala Ser Gln Gly Val Ile Thr Thr Pro Pro Pro Pro 
  1               5                  10                  15
Ser Met Pro His Lys Glu Arg Tyr Phe Asp Arg Ile Asn Glu Asn Asp 
             20                  25                  30
Pro Glu Tyr Ile Arg Glu Arg Asn Met Ser Pro Asp Leu Arg Gln Asp 
         35                  40                  45
Phe Asn Met Met Glu Gln Arg Lys Arg Val Thr Gln Ile Leu Gln Ser 
     50                  55                  60
Pro Ala Phe Arg Glu Asp Leu Glu Cys Leu Ile Gln Glu Gln Met Lys 
 65                  70                  75                  80
Lys Gly His Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp 
                 85                  90                  95
Tyr Ile Met Ala Asn Ser Phe Ser Gly Phe Ser Ser Pro Pro Leu Ser 
             100                105                110
Leu Gly Met Val Thr Pro Ile Asn Asp Leu Pro Gly Ala Asp Thr Ser 
         115                120                125
Ser Tyr Val Lys Gly Glu Lys Leu Thr Arg Cys Lys Leu Ala Ser Leu 
     130                135                140
Tyr Arg Leu Val Asp Leu Phe Gly Trp Ala His Leu Ala Asn Thr Tyr 
 145                150                155                160
Ile Ser Val Arg Ile Ser Lys Glu Gln Asp His Ile Ile Ile Ile Pro 
                 165                170                175
Arg Gly Leu Ser Phe Ser Glu Ala Thr Ala Ser Asn Leu Val Lys Val 
             180                185                190
Asn Ile Ile Gly Glu Val Val Asp Gln Gly Ser Thr Asn Leu Lys Ile 
         195                200                205
Asp His Thr Gly Phe Ser Pro His Ala Ala Ile Tyr Ser Thr Arg Pro 
     210                215                220
Asp Val Lys Cys Val Ile His Ile His Thr Leu Ala Thr Ala Ala Val 
 225                230                235                240
Ser Ser Met Lys Cys Gly Ile Leu Pro Ile Ser Gln Glu Ser Leu Leu 
                 245                250                255
Leu Gly Asp Val Ala Tyr Tyr Asp Tyr Gln Gly Ser Leu Glu Glu Gln 
             260                265                270
Glu Glu Arg Ile Gln Leu Gln Lys Val Leu Gly Pro Ser Cys Lys Val 
         275                280                285
Leu Val Leu Arg Asn His Gly Val Val Ala Leu Gly Glu Thr Leu Glu 
     290                295                300
Glu Ala Phe His Tyr Ile Phe Asn Val Gln Leu Ala Cys Glu Ile Gln 
 305                310                315                320
Val Gln Ala Leu Ala Gly Ala Gly Gly Val Asp Asn Leu His Val Leu 
                 325                330                335
Asp Phe Gln Lys Tyr Lys Ala Phe Thr Tyr Thr Val Ala Ala Ser Gly 
             340                345                350
Gly Gly Gly Val Asn Met Gly Ser His Gln Lys Trp Lys Val Gly Glu 
         355                360                365
Ile Glu Phe Glu Gly Leu Met Arg Thr Leu Asp Asn Leu Gly Tyr Arg 
     370                375                380
Thr Gly Tyr Ala Tyr Arg His Pro Leu Ile Arg Glu Lys Pro Arg His 
 385                390                395                400
Lys Ser Asp Val Glu Ile Pro Ala Thr Val Thr Ala Phe Ser Phe Glu 
                 405                410                415
Asp Asp Thr Val Pro Leu Ser Pro Leu Lys Tyr Met Ala Gln Arg Gln 
             420                425                430
Gln Arg Glu Lys Thr Arg Trp Leu Asn Ser Pro Asn Thr Tyr Met Lys 
         435                440                445
Val Asn Val Pro Glu Glu Ser Arg Asn Gly Glu Thr Ser Pro Arg Thr 
     450                455                460
Lys Ile Thr Trp Met Lys Ala Glu Asp Ser Ser Lys Val Ser Gly Gly 
 465                470                475                480
Thr Pro Ile Lys Ile Glu Asp Pro Asn Gln Phe Val Pro Leu Asn Thr 
                 485                490                495
Asn Pro Asn Glu Val Leu Glu Lys Arg Asn Lys Ile Arg Glu Gln Asn 
             500                505                510
Arg Tyr Asp Leu Lys Thr Ala Gly Pro Gln Ser Gln Leu Leu Ala Gly 
         515                520                525
Ile Val Val Asp Lys Pro Pro Ser Thr Met Gln Phe Glu Asp Asp Asp 
     530                535                540
His Gly Pro Pro Ala Pro Pro Asn Pro Phe Ser His Leu Thr Glu Gly 
 545                550                555                560
Glu Leu Glu Glu Tyr Lys Arg Thr Ile Glu Arg Lys Gln Gln Gly Leu 
                 565                570                575
Glu Asp Ala Glu Gln Glu Leu Leu Ser Asp Asp Ala Ser Ser Val Ser 
             580                585                590
Gln Ile Gln Ser Gln Thr Gln Ser Pro Gln Asn Val Pro Glu Lys Leu 
         595                600                605
Glu Glu Asn His Glu Leu Phe Ser Lys Ser Phe Ile Ser Met Glu Val 
     610                615                620
Pro Val Met Val Val Asn Gly Lys Asp Asp Met His Asp Val Glu Asp 
 625                630                635                640
Glu Leu Ala Lys Arg Val Ser Arg Leu Ser Thr Ser Thr Thr Ile Glu 
                 645                650                655
Asn Ile Glu Ile Thr Ile Lys Ser Pro Glu Lys Ile Glu Glu Val Leu 
             660                665                670
Ser Pro Glu Gly Ser Pro Ser Lys Ser Pro Ser Lys Lys Lys Lys Lys 
         675                680                685
Phe Arg Thr Pro Ser Phe Leu Lys Lys Asn Lys Lys Lys Glu Lys Val 
     690                695                700
Glu Ala 
 705



<210> 6902
<211> 601
<212> DNA
<213> Rattus norvegicus
<308> AI169005
<400> 6902

atagaaaac  cagatttat  taactatta  aaagacaaa  tatcattga  agtactttg  60
agacttcat  tcagatgat  tactctgtg  cagtcaagg  cctaagcta  gagaatgta  120
cagagctga  ggtaaatgc  gaggaacag  agtagcaca  aagcatttg  catgacgag  180
tgtggttga  ccccagtag  gggcccatg  gtccgtgga  aatgctaaa  gctgtgccc  240
cagaggcct  tgcttttta  ctcagggat  agagagtcc  cctaagtcc  agagacatc  300
aagctcccc  cctcacttt  gcccagcgt  agcactgtg  acacgacac  caggcctcg  360
agctgacag  ttgcacaca  caaaggcag  aattagagg  cctctcaga  gataactag  420
cacaggaag  ttaggggta  atgagaaac  acaaaaacc  gttcagtta  ttcaccttt  480
ttaatagag  tcagagtct  ttctgctgg  gacagcttg  tgtctcatt  tagtttgtc  540
tgagaaatg  gttttggaa  agaaaaaag  ctttcacca  ctccattct  gagtgaaga  600
g  601



<210> 6903
<211> 236
<212> PRT
<213> Rattus norvegicus
<308> Q04753
<400> 6903

Met Ser Phe Leu Lys Ser Phe Pro Pro Pro Gly Ser Ala Asp Gly Leu 
  1               5                  10                  15
Arg Leu Gln Gln Pro Asp Thr Glu Ala Val Leu Asn Gly Lys Gly Leu 
             20                  25                  30
Gly Thr Gly Thr Leu Tyr Ile Ala Glu Ser Arg Leu Ser Trp Leu Asp 
         35                  40                  45
Gly Ser Gly Leu Gly Phe Ser Leu Glu Tyr Pro Thr Ile Ser Leu His 
     50                  55                  60
Ala Val Ser Arg Asp Pro Asn Ala Tyr Pro Gln Glu His Leu Tyr Val 
 65                  70                  75                  80
Met Val Asn Ala Arg Phe Gly Glu Glu Ser Lys Glu Pro Phe Ser Asp 
                 85                  90                  95
Glu Asp Glu Asp Asp Asn Asp Asp Val Glu Pro Ile Ser Glu Phe Arg 
             100                105                110
Phe Val Pro Ser Asp Lys Ser Ala Leu Glu Ala Met Phe Thr Ala Met 
         115                120                125
Cys Glu Cys Gln Ala Leu His Pro Asp Pro Glu Asp Glu Asp Ser Asp 
     130                135                140
Asp Tyr Asp Gly Glu Glu Tyr Asp Val Glu Ala His Glu Gln Gly Gln 
 145                150                155                160
Gly Asp Ile Pro Thr Phe Tyr Thr Tyr Glu Glu Gly Leu Ser His Leu 
                 165                170                175
Thr Ala Glu Gly Gln Ala Thr Leu Glu Arg Leu Glu Gly Met Leu Ser 
             180                185                190
Gln Ser Val Ser Ser Gln Tyr Asn Met Ala Gly Val Arg Thr Glu Asp 
         195                200                205
Ser Val Arg Thr Tyr Glu Asp Gly Met Glu Val Glu Thr Thr Pro Thr 
     210                215                220
Val Ala Gly Gln Phe Glu Asp Ala Asp Val Asp His 
 225                230                235



<210> 6904
<211> 421
<212> DNA
<213> Homo sapiens
<308> AA832121
<400> 6904

ttttttttc  aattgttga  taaaataat  taaaagtgt  ctgtttgtt  agaacaagg  60
caaggggac  tccctacat  ttataccta  gaagaagga  tatcccatt  aacagcgga  120
gggcaagcc  cgttggaga  attagaagg  atgctttct  agtctgtga  cagccaata  180
aatatggca  gcgtccgaa  agaagactc  gtaagaaat  atgaaggtg  gtgtttttt  240
tcttcagac  gggaaatcg  agccaagtt  tctcttaga  gccagaaga  tgcagagtc  300
ttgctccag  ctctcatac  gttttggct  tgaaggagt  acatgtggc  gtcctgtgc  360
ttctaaccc  aagccgatt  tgtgccaca  ctggattta  agcacatct  tcaatattt  420
c  421



<210> 6905
<211> 237
<212> PRT
<213> Homo sapiens
<308> NP_001284
<400> 6905

Met Ser Phe Leu Lys Ser Phe Pro Pro Pro Gly Pro Ala Glu Gly Leu 
  1               5                  10                  15
Leu Arg Gln Gln Pro Asp Thr Glu Ala Val Leu Asn Gly Lys Gly Leu 
             20                  25                  30
Gly Thr Gly Thr Leu Tyr Ile Ala Glu Ser Arg Leu Ser Trp Leu Asp 
         35                  40                  45
Gly Ser Gly Leu Gly Phe Ser Leu Glu Tyr Pro Thr Ile Ser Leu His 
     50                  55                  60
Ala Leu Ser Arg Asp Arg Ser Asp Cys Leu Gly Glu His Leu Tyr Val 
 65                  70                  75                  80
Met Val Asn Ala Lys Phe Glu Glu Glu Ser Lys Glu Pro Val Ala Asp 
                 85                  90                  95
Glu Glu Glu Glu Asp Ser Asp Asp Asp Val Glu Pro Ile Thr Glu Phe 
             100                105                110
Arg Phe Val Pro Ser Asp Lys Ser Ala Leu Glu Ala Met Phe Thr Ala 
         115                120                125
Met Cys Glu Cys Gln Ala Leu His Pro Asp Pro Glu Asp Glu Asp Ser 
     130                135                140
Asp Asp Tyr Asp Gly Glu Glu Tyr Asp Val Glu Ala His Glu Gln Gly 
 145                150                155                160
Gln Gly Asp Ile Pro Thr Phe Tyr Thr Tyr Glu Glu Gly Leu Ser His 
                 165                170                175
Leu Thr Ala Glu Gly Gln Ala Thr Leu Glu Arg Leu Glu Gly Met Leu 
             180                185                190
Ser Gln Ser Val Ser Ser Gln Tyr Asn Met Ala Gly Val Arg Thr Glu 
         195                200                205
Asp Ser Ile Arg Asp Tyr Glu Asp Gly Met Glu Val Asp Thr Thr Pro 
     210                215                220
Thr Val Ala Gly Gln Phe Glu Asp Ala Asp Val Asp His 
 225                230                235



<210> 6906
<211> 581
<212> DNA
<213> Rattus norvegicus
<308> AI169370
<400> 6906

cttaaagct  ttactttga  acgtcatgg  aaacttaag  ggtacacat  gagaagaca  60
gatcacaga  gggaaacag  atagaagca  cgatgcctg  agctagtgc  ggagctgga  120
ttgagtttg  catgataca  ggactgcag  aatgaacta  tattcctct  cttcttcct  180
accctcacc  tccacagaa  ccacaccaa  ctcctcata  tccttctct  gggcagcca  240
gtcctcacg  gcctcagag  actctccct  ctccatgcc  tcacccacg  accagtgca  300
aaaggcacg  ttggcatac  tcagatcaa  cttgtgatc  aggcgagcc  aagcctcag  360
aatggctgt  gtgttgctc  gcatacaca  agctctctg  accttggcc  ggtcgccac  420
aggtaccac  gtgggaggc  ggtaattaa  gccaacctt  aagccagtg  ggcaccagt  480
cacaaactg  atgctgcgc  tggtcttga  ggtggcaat  gcagcattg  catctttgg  540
gaccacatc  ccacggtac  gcaggcagc  agccatgta  t  581



<210> 6907
<211> 451
<212> PRT
<213> Rattus norvegicus
<308> P02551
<400> 6907

Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
  1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
             20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
         35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
     50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
 65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                 85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
             100                105                110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
         115                120                125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
     130                135                140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
 145                150                155                160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                 165                170                175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
             180                185                190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
         195                200                205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
     210                215                220
Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala 
 225                230                235                240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                 245                250                255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
             260                265                270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
         275                280                285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
     290                295                300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
 305                310                315                320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                 325                330                335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
             340                345                350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
         355                360                365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
     370                375                380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
 385                390                395                400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                 405                410                415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
             420                425                430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly 
         435                440                445
Glu Glu Tyr 
     450



<210> 6908
<211> 1636
<212> DNA
<213> Homo sapiens
<308> BC006379
<400> 6908

ggcacgagg  tcgactctt  gcttgtcgg  gacggtaac  gggacccgg  gtctgctcc  60
gtcgccttc  cctcctaat  cctagccac  atgcgtgag  gcatctcca  ccacgttgg  120
caggctggt  tccagattg  caatgcctg  tgggagctc  actgcctgg  acacggcat  180
cagcccgat  gccagatgc  aagtgacaa  accattggg  gaggagatg  ctccttcaa  240
accttcttc  gtgagacgg  cgctggcaa  cacgtgccc  gggctgtgt  tgtagactt  300
gaacccaca  tcattgatg  agttcgcac  ggcacctac  gccagctct  ccaccctga  360
cagctcatc  caggcaagg  agatgctgc  aataactat  cccgagggc  ctacaccat  420
ggcaaggag  tcattgacc  tgtgttgga  cgaattcgc  agctggctg  ccagtgcac  480
ggtcttcag  gcttcttgg  tttccacag  tttggtggg  gaactggtt  tgggttcac  540
tccctgctc  tggaacgtc  ctcagttga  tatggcaag  agtccaagc  ggagttctc  600
atttaccca  caccccagg  ttccacagc  gtagttgag  cctacaact  catcctcac  660
acccacacc  ccctggagc  ctctgattg  gccttcatg  tagacaatg  ggccatcta  720
gacatctgt  gtagaaacc  cgatatcga  cgcccaacc  acactaacc  taaccgcct  780
attagccag  ttgtgtcct  catcactgc  tccctgaga  ttgatggag  cctgaatgt  840
gacctgaca  aattccaga  caacctggt  ccctacccc  gcatccact  ccctctggc  900
acatatgcc  ctgtcatct  tgctgagaa  gcctaccat  aacagcttt  tgtagcaga  960
atcaccaat  cttgctttg  gccagccaa  cagatggtg  aatgtgacc  tcgccatgg  1020
aaatacatg  cttgctgcc  gttgtaccg  ggtgacgtg  ttcccaaag  tgtcaatgc  1080
gccattgcc  ccatcaaaa  caagcgcag  atccagttt  tggattggt  ccccactgg  1140
ttcaaggtt  gcatcaact  ccagcctcc  actgtggtg  ctggtggag  cctggccaa  1200
gtacagaga  ctgtgtgca  gctgagcaa  accacagcc  ttgctgagg  ctgggctcg  1260
ctggaccac  agtttgacc  gatgtatgc  aagcgtgcc  ttgttcact  gtacgtggg  1320
gaggggatg  aggaaggcg  gttttcaga  gcccgtgaa  atatggctg  ccttgagaa  1380
gattatgag  aggttggtg  ggattctgt  gaaggagag  gtgaggaag  aggagagga  1440
tactaatta  ccattcctt  tggccctgc  gcatgtcat  ctcccagaa  ttcagcttc  1500
gcttaactg  cagacgtta  agctttctg  ttagattgt  ttcacttgg  gatcatgtc  1560
tttccatgt  tacctgtaa  atttttcca  catatctca  agtaaagtc  ttaacatca  1620
aaaaaaaaa  aaaaaa  1636



<210> 6909
<211> 451
<212> PRT
<213> Homo sapiens
<308> P05209
<400> 6909

Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
  1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
             20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
         35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
     50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
 65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                 85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
             100                105                110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
         115                120                125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
     130                135                140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
 145                150                155                160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                 165                170                175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
             180                185                190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
         195                200                205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
     210                215                220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala 
 225                230                235                240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                 245                250                255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
             260                265                270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
         275                280                285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
     290                295                300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
 305                310                315                320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                 325                330                335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
             340                345                350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
         355                360                365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
     370                375                380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
 385                390                395                400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                 405                410                415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
             420                425                430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly 
         435                440                445
Glu Glu Tyr 
     450



<210> 6910
<211> 542
<212> DNA
<213> Rattus norvegicus
<308> AI170613
<400> 6910

ttatattat  tatttggaa  tgtttgtaa  agtacagtg  aactaaatt  cagagacaa  60
ggctgtcag  ttaggcatc  tccgtttat  atagaaggg  aggcatggg  aattattta  120
atgatgaaa  agttcagaa  atcagtgga  tgggcagct  catgtgaca  catttcaac  180
gtgatttca  tcgacatac  ttccaacaa  gtcgccatc  ctatatacg  agtaatcct  240
gtcgtctag  actactttg  tgcctccat  ttctgggag  agaacttta  ctccaactt  300
cacactgac  ggctgaatc  ctcttgtgc  tttcctttc  cgcctgatc  cacagccac  360
accgttgct  gcaatacgt  tccttgaga  ttttctgga  gcataatgc  acctttggt  420
acagtttca  cggcactcc  ttcaaccaa  actctgtca  atagcggaa  atacttcct  480
aaagcttgt  cagccatga  ttacgccgc  gcagctccg  actctgcac  cggactcct  540
ct  542



<210> 6911
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> P26772
<400> 6911

Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val Leu 
  1               5                  10                  15
Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met Leu 
             20                  25                  30
Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala Val 
         35                  40                  45
Gly Ser Gly Gly Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser Val 
     50                  55                  60
Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys Val 
 65                  70                  75                  80
Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile Leu 
                 85                  90                  95
Gly Lys Tyr Val Asp 
             100



<210> 6912
<211> 309
<212> DNA
<213> Homo sapiens
<308> X75821
<400> 6912

atggcagga  aagcgttta  aaagtttct  ccactcttt  accgagtat  ggttgaaag  60
agtgctgct  aaactgtaa  caaaggagg  attatgctt  cagaaaaat  tcaaggaaa  120
gtattgcaa  caacagtag  cgctgttgg  tcgggttct  aaggaaagg  tggagagat  180
caaccagtt  gcgtgaaag  tggagataa  gttcttctc  cagaatatg  aggcaccaa  240
gtagttcta  atgacaagg  ttatttcct  tttagagat  gtgacattc  tggaaagta  300
gtagactga  309



<210> 6913
<211> 101
<212> PRT
<213> Homo sapiens
<308> Q04984
<400> 6913

Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val Leu 
  1               5                  10                  15
Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met Leu 
             20                  25                  30
Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala Val 
         35                  40                  45
Gly Ser Gly Ser Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser Val 
     50                  55                  60
Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys Val 
 65                  70                  75                  80
Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile Leu 
                 85                  90                  95
Gly Lys Tyr Val Asp 
             100



<210> 6914
<211> 542
<212> DNA
<213> Rattus norvegicus
<308> AI170613
<400> 6914

ttatattat  tatttggaa  tgtttgtaa  agtacagtg  aactaaatt  cagagacaa  60
ggctgtcag  ttaggcatc  tccgtttat  atagaaggg  aggcatggg  aattattta  120
atgatgaaa  agttcagaa  atcagtgga  tgggcagct  catgtgaca  catttcaac  180
gtgatttca  tcgacatac  ttccaacaa  gtcgccatc  ctatatacg  agtaatcct  240
gtcgtctag  actactttg  tgcctccat  ttctgggag  agaacttta  ctccaactt  300
cacactgac  ggctgaatc  ctcttgtgc  tttcctttc  cgcctgatc  cacagccac  360
accgttgct  gcaatacgt  tccttgaga  ttttctgga  gcataatgc  acctttggt  420
acagtttca  cggcactcc  ttcaaccaa  actctgtca  atagcggaa  atacttcct  480
aaagcttgt  cagccatga  ttacgccgc  gcagctccg  actctgcac  cggactcct  540
ct  542



<210> 6915
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> P26772
<400> 6915

Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val Leu 
  1               5                  10                  15
Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met Leu 
             20                  25                  30
Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala Val 
         35                  40                  45
Gly Ser Gly Gly Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser Val 
     50                  55                  60
Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys Val 
 65                  70                  75                  80
Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile Leu 
                 85                  90                  95
Gly Lys Tyr Val Asp 
             100



<210> 6916
<211> 309
<212> DNA
<213> Homo sapiens
<308> X75821
<400> 6916

atggcagga  aagcgttta  aaagtttct  ccactcttt  accgagtat  ggttgaaag  60
agtgctgct  aaactgtaa  caaaggagg  attatgctt  cagaaaaat  tcaaggaaa  120
gtattgcaa  caacagtag  cgctgttgg  tcgggttct  aaggaaagg  tggagagat  180
caaccagtt  gcgtgaaag  tggagataa  gttcttctc  cagaatatg  aggcaccaa  240
gtagttcta  atgacaagg  ttatttcct  tttagagat  gtgacattc  tggaaagta  300
gtagactga  309



<210> 6917
<211> 101
<212> PRT
<213> Homo sapiens
<308> Q04984
<400> 6917

Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val Leu 
  1               5                  10                  15
Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met Leu 
             20                  25                  30
Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala Val 
         35                  40                  45
Gly Ser Gly Ser Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser Val 
     50                  55                  60
Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys Val 
 65                  70                  75                  80
Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile Leu 
                 85                  90                  95
Gly Lys Tyr Val Asp 
             100



<210> 6918
<211> 542
<212> DNA
<213> Rattus norvegicus
<308> AI170613
<400> 6918

ttatattat  tatttggaa  tgtttgtaa  agtacagtg  aactaaatt  cagagacaa  60
ggctgtcag  ttaggcatc  tccgtttat  atagaaggg  aggcatggg  aattattta  120
atgatgaaa  agttcagaa  atcagtgga  tgggcagct  catgtgaca  catttcaac  180
gtgatttca  tcgacatac  ttccaacaa  gtcgccatc  ctatatacg  agtaatcct  240
gtcgtctag  actactttg  tgcctccat  ttctgggag  agaacttta  ctccaactt  300
cacactgac  ggctgaatc  ctcttgtgc  tttcctttc  cgcctgatc  cacagccac  360
accgttgct  gcaatacgt  tccttgaga  ttttctgga  gcataatgc  acctttggt  420
acagtttca  cggcactcc  ttcaaccaa  actctgtca  atagcggaa  atacttcct  480
aaagcttgt  cagccatga  ttacgccgc  gcagctccg  actctgcac  cggactcct  540
ct  542



<210> 6919
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> P26772
<400> 6919

Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val Leu 
  1               5                  10                  15
Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met Leu 
             20                  25                  30
Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala Val 
         35                  40                  45
Gly Ser Gly Gly Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser Val 
     50                  55                  60
Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys Val 
 65                  70                  75                  80
Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile Leu 
                 85                  90                  95
Gly Lys Tyr Val Asp 
             100



<210> 6920
<211> 309
<212> DNA
<213> Homo sapiens
<308> X75821
<400> 6920

atggcagga  aagcgttta  aaagtttct  ccactcttt  accgagtat  ggttgaaag  60
agtgctgct  aaactgtaa  caaaggagg  attatgctt  cagaaaaat  tcaaggaaa  120
gtattgcaa  caacagtag  cgctgttgg  tcgggttct  aaggaaagg  tggagagat  180
caaccagtt  gcgtgaaag  tggagataa  gttcttctc  cagaatatg  aggcaccaa  240
gtagttcta  atgacaagg  ttatttcct  tttagagat  gtgacattc  tggaaagta  300
gtagactga  309



<210> 6921
<211> 101
<212> PRT
<213> Homo sapiens
<308> Q04984
<400> 6921

Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val Leu 
  1               5                  10                  15
Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met Leu 
             20                  25                  30
Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala Val 
         35                  40                  45
Gly Ser Gly Ser Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser Val 
     50                  55                  60
Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys Val 
 65                  70                  75                  80
Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile Leu 
                 85                  90                  95
Gly Lys Tyr Val Asp 
             100



<210> 6922
<211> 542
<212> DNA
<213> Rattus norvegicus
<308> AI170613
<400> 6922

ttatattat  tatttggaa  tgtttgtaa  agtacagtg  aactaaatt  cagagacaa  60
ggctgtcag  ttaggcatc  tccgtttat  atagaaggg  aggcatggg  aattattta  120
atgatgaaa  agttcagaa  atcagtgga  tgggcagct  catgtgaca  catttcaac  180
gtgatttca  tcgacatac  ttccaacaa  gtcgccatc  ctatatacg  agtaatcct  240
gtcgtctag  actactttg  tgcctccat  ttctgggag  agaacttta  ctccaactt  300
cacactgac  ggctgaatc  ctcttgtgc  tttcctttc  cgcctgatc  cacagccac  360
accgttgct  gcaatacgt  tccttgaga  ttttctgga  gcataatgc  acctttggt  420
acagtttca  cggcactcc  ttcaaccaa  actctgtca  atagcggaa  atacttcct  480
aaagcttgt  cagccatga  ttacgccgc  gcagctccg  actctgcac  cggactcct  540
ct  542



<210> 6923
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> P26772
<400> 6923

Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val Leu 
  1               5                  10                  15
Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met Leu 
             20                  25                  30
Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala Val 
         35                  40                  45
Gly Ser Gly Gly Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser Val 
     50                  55                  60
Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys Val 
 65                  70                  75                  80
Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile Leu 
                 85                  90                  95
Gly Lys Tyr Val Asp 
             100



<210> 6924
<211> 309
<212> DNA
<213> Homo sapiens
<308> X75821
<400> 6924

atggcagga  aagcgttta  aaagtttct  ccactcttt  accgagtat  ggttgaaag  60
agtgctgct  aaactgtaa  caaaggagg  attatgctt  cagaaaaat  tcaaggaaa  120
gtattgcaa  caacagtag  cgctgttgg  tcgggttct  aaggaaagg  tggagagat  180
caaccagtt  gcgtgaaag  tggagataa  gttcttctc  cagaatatg  aggcaccaa  240
gtagttcta  atgacaagg  ttatttcct  tttagagat  gtgacattc  tggaaagta  300
gtagactga  309



<210> 6925
<211> 101
<212> PRT
<213> Homo sapiens
<308> Q04984
<400> 6925

Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val Leu 
  1               5                  10                  15
Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met Leu 
             20                  25                  30
Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala Val 
         35                  40                  45
Gly Ser Gly Ser Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser Val 
     50                  55                  60
Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys Val 
 65                  70                  75                  80
Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile Leu 
                 85                  90                  95
Gly Lys Tyr Val Asp 
             100



<210> 6926
<211> 542
<212> DNA
<213> Rattus norvegicus
<308> AI170613
<400> 6926

ttatattat  tatttggaa  tgtttgtaa  agtacagtg  aactaaatt  cagagacaa  60
ggctgtcag  ttaggcatc  tccgtttat  atagaaggg  aggcatggg  aattattta  120
atgatgaaa  agttcagaa  atcagtgga  tgggcagct  catgtgaca  catttcaac  180
gtgatttca  tcgacatac  ttccaacaa  gtcgccatc  ctatatacg  agtaatcct  240
gtcgtctag  actactttg  tgcctccat  ttctgggag  agaacttta  ctccaactt  300
cacactgac  ggctgaatc  ctcttgtgc  tttcctttc  cgcctgatc  cacagccac  360
accgttgct  gcaatacgt  tccttgaga  ttttctgga  gcataatgc  acctttggt  420
acagtttca  cggcactcc  ttcaaccaa  actctgtca  atagcggaa  atacttcct  480
aaagcttgt  cagccatga  ttacgccgc  gcagctccg  actctgcac  cggactcct  540
ct  542



<210> 6927
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> P26772
<400> 6927

Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val Leu 
  1               5                  10                  15
Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met Leu 
             20                  25                  30
Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala Val 
         35                  40                  45
Gly Ser Gly Gly Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser Val 
     50                  55                  60
Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys Val 
 65                  70                  75                  80
Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile Leu 
                 85                  90                  95
Gly Lys Tyr Val Asp 
             100



<210> 6928
<211> 309
<212> DNA
<213> Homo sapiens
<308> X75821
<400> 6928

atggcagga  aagcgttta  aaagtttct  ccactcttt  accgagtat  ggttgaaag  60
agtgctgct  aaactgtaa  caaaggagg  attatgctt  cagaaaaat  tcaaggaaa  120
gtattgcaa  caacagtag  cgctgttgg  tcgggttct  aaggaaagg  tggagagat  180
caaccagtt  gcgtgaaag  tggagataa  gttcttctc  cagaatatg  aggcaccaa  240
gtagttcta  atgacaagg  ttatttcct  tttagagat  gtgacattc  tggaaagta  300
gtagactga  309



<210> 6929
<211> 101
<212> PRT
<213> Homo sapiens
<308> Q04984
<400> 6929

Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val Leu 
  1               5                  10                  15
Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met Leu 
             20                  25                  30
Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala Val 
         35                  40                  45
Gly Ser Gly Ser Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser Val 
     50                  55                  60
Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys Val 
 65                  70                  75                  80
Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile Leu 
                 85                  90                  95
Gly Lys Tyr Val Asp 
             100



<210> 6930
<211> 542
<212> DNA
<213> Rattus norvegicus
<308> AI170613
<400> 6930

ttatattat  tatttggaa  tgtttgtaa  agtacagtg  aactaaatt  cagagacaa  60
ggctgtcag  ttaggcatc  tccgtttat  atagaaggg  aggcatggg  aattattta  120
atgatgaaa  agttcagaa  atcagtgga  tgggcagct  catgtgaca  catttcaac  180
gtgatttca  tcgacatac  ttccaacaa  gtcgccatc  ctatatacg  agtaatcct  240
gtcgtctag  actactttg  tgcctccat  ttctgggag  agaacttta  ctccaactt  300
cacactgac  ggctgaatc  ctcttgtgc  tttcctttc  cgcctgatc  cacagccac  360
accgttgct  gcaatacgt  tccttgaga  ttttctgga  gcataatgc  acctttggt  420
acagtttca  cggcactcc  ttcaaccaa  actctgtca  atagcggaa  atacttcct  480
aaagcttgt  cagccatga  ttacgccgc  gcagctccg  actctgcac  cggactcct  540
ct  542



<210> 6931
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> P26772
<400> 6931

Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val Leu 
  1               5                  10                  15
Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met Leu 
             20                  25                  30
Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala Val 
         35                  40                  45
Gly Ser Gly Gly Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser Val 
     50                  55                  60
Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys Val 
 65                  70                  75                  80
Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile Leu 
                 85                  90                  95
Gly Lys Tyr Val Asp 
             100



<210> 6932
<211> 309
<212> DNA
<213> Homo sapiens
<308> X75821
<400> 6932

atggcagga  aagcgttta  aaagtttct  ccactcttt  accgagtat  ggttgaaag  60
agtgctgct  aaactgtaa  caaaggagg  attatgctt  cagaaaaat  tcaaggaaa  120
gtattgcaa  caacagtag  cgctgttgg  tcgggttct  aaggaaagg  tggagagat  180
caaccagtt  gcgtgaaag  tggagataa  gttcttctc  cagaatatg  aggcaccaa  240
gtagttcta  atgacaagg  ttatttcct  tttagagat  gtgacattc  tggaaagta  300
gtagactga  309



<210> 6933
<211> 101
<212> PRT
<213> Homo sapiens
<308> Q04984
<400> 6933

Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val Leu 
  1               5                  10                  15
Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met Leu 
             20                  25                  30
Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala Val 
         35                  40                  45
Gly Ser Gly Ser Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser Val 
     50                  55                  60
Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys Val 
 65                  70                  75                  80
Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile Leu 
                 85                  90                  95
Gly Lys Tyr Val Asp 
             100



<210> 6934
<211> 648
<212> DNA
<213> Rattus norvegicus
<308> AI170685
<400> 6934

acaccaact  ctttttatt  tcaagtttc  gaaaccttt  acaaaatgg  tttaaaaaa  60
agccaaaaa  ctttacaac  atggctaat  taatttttt  cattgttcc  agtcagctt  120
aaacccatt  tgtgcaaag  ccagttttc  atgcatcta  tgatagata  aggctatga  180
ttctttatt  tatttgtag  agcttatgc  ggtgcagcc  aacacacag  ttcaggacg  240
attgtacaa  ctttacaat  ctggatctg  gtttaaaat  ggaaacata  actctacac  300
aaactgata  aaatcaagc  gataccagg  ctgaaactt  taacccaca  gtgaaaggg  360
gtcttattt  aagtgcttt  ctctgctat  gaacagtcg  aatgaagac  taaagctcc  420
tggttagtt  aaattatac  ctctgtgga  actatacca  gtttagaag  tacacatag  480
tcagcagat  tccatcagt  catctggac  catcaggta  tccagcagc  ggcaaatcc  540
gcaaatgtg  agaaaatcc  ccgtgcagt  gcctgcagt  tactgatgg  cacactgca  600
tccaggtcc  tgatggctg  tgctttcct  atcagagct  tcgttgta  648



<210> 6935
<211> 412
<212> PRT
<213> Rattus norvegicus
<308> O35824
<400> 6935

Met Ala Asn Val Ala Asp Thr Lys Leu Tyr Asp Ile Leu Gly Val Pro 
  1               5                  10                  15
Pro Gly Ala Ser Glu Asn Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala 
             20                  25                  30
Lys Glu Tyr His Pro Asp Lys Asn Pro Asn Ala Gly Asp Lys Phe Lys 
         35                  40                  45
Glu Ile Ser Phe Ala Tyr Glu Val Leu Ser Asn Pro Glu Lys Arg Glu 
     50                  55                  60
Leu Tyr Asp Arg Tyr Gly Glu Gln Gly Leu Arg Glu Gly Ser Gly Gly 
 65                  70                  75                  80
Gly Gly Gly Met Asp Asp Ile Phe Ser His Ile Phe Gly Gly Gly Leu 
                 85                  90                  95
Phe Gly Phe Met Gly Asn Gln Ser Arg Ser Arg Asn Gly Arg Arg Arg 
             100                105                110
Gly Glu Asp Met Met His Pro Leu Lys Val Ser Leu Glu Asp Leu Tyr 
         115                120                125
Asn Gly Lys Thr Thr Lys Leu Gln Leu Ser Lys Asn Val Leu Cys Ser 
     130                135                140
Ala Cys Ser Gly Gln Gly Gly Lys Ser Gly Ala Val Gln Lys Cys Ser 
 145                150                155                160
Ala Cys Arg Gly Arg Gly Val Arg Ile Met Ile Arg Gln Leu Ala Pro 
                 165                170                175
Gly Met Val Gln Gln Met Gln Ser Val Cys Ser Asp Cys Asn Gly Glu 
             180                185                190
Gly Glu Val Ile Asn Glu Lys Asp Arg Cys Lys Lys Cys Glu Gly Lys 
         195                200                205
Lys Val Ile Lys Glu Val Lys Ile Leu Glu Val His Val Asp Lys Gly 
     210                215                220
Met Lys His Gly Gln Arg Ile Thr Phe Thr Gly Glu Ala Asp Gln Ala 
 225                230                235                240
Pro Gly Val Glu Pro Gly Asp Ile Val Leu Phe Val Gln Glu Lys Glu 
                 245                250                255
His Glu Val Phe Gln Arg Asp Gly Asn Asp Leu His Met Thr Tyr Lys 
             260                265                270
Ile Gly Leu Val Glu Ala Leu Cys Gly Phe Gln Phe Thr Phe Lys His 
         275                280                285
Leu Asp Ala Arg Gln Ile Val Val Lys Tyr Pro Pro Gly Lys Val Ile 
     290                295                300
Glu Pro Gly Cys Val Arg Val Val Arg Gly Glu Gly Met Pro Gln Tyr 
 305                310                315                320
Arg Asn Pro Phe Glu Lys Gly Asp Leu Tyr Ile Lys Phe Asp Val Gln 
                 325                330                335
Phe Pro Glu Asn Asn Trp Ile Asn Pro Asp Lys Leu Ser Glu Leu Glu 
             340                345                350
Asp Leu Leu Pro Ser Arg Pro Glu Val Pro Asn Val Ile Gly Glu Thr 
         355                360                365
Glu Glu Val Glu Leu Gln Glu Phe Asp Ser Thr Arg Gly Ser Gly Gly 
     370                375                380
Gly Gln Arg Arg Glu Ala Tyr Asn Asp Ser Ser Asp Glu Glu Ser Ser 
 385                390                395                400
Ser His His Gly Pro Gly Val Gln Cys Ala His Gln 
                 405                410



<210> 6936
<211> 1993
<212> DNA
<213> Homo sapiens
<308> NM_005880
<400> 6936

ccgctctgt  tgcttcgcc  ccttctccc  gagcactgc  cggccggcc  ccatggcta  60
cgtggctga  acgaagctg  acgacatcc  gggcgtccc  cccggcgcc  gcgagaacg  120
gctgaagaa  gcatacaga  agttagcca  ggaatatca  cctgataag  atccaaatg  180
aggagacaa  tttaaagaa  taagttttg  atatgaagt  ctatcaaat  ctgagaagc  240
tgagttata  gacagatac  gagagcaag  tcttcggga  ggcagcggc  gaggtggtg  300
catggatga  attttctct  acatttttg  tgggggatt  ttcggcttc  tgggcaatc  360
gagtagaag  cgaaatggc  gaagaagag  agaggacat  atgcatcca  tcaaagtat  420
tttagaaga  ctgtataat  gcaagacaa  caaactaca  cttagcaag  atgtgctct  480
tagtgcatg  agtggccaa  gcggaaagt  tggagctgt  caaaagtgt  gtgcttgtc  540
aggtcgagg  gtgcgcatc  tgatcagac  gctggctcc  gggatggta  aacagatgc  600
gtctgtgtg  tctgattgt  atggagaag  agaggtaat  aatgaaaaa  accgctgta  660
aaaatgtga  gggaagaag  tgattaaag  agtcaagat  cttgaagtc  acgtagaca  720
aggcatgaa  catggacag  gaattacat  cactgggga  gcagaccag  ccccaggag  780
ggaacccgg  gacattgtt  ttttgctac  ggagaaaga  catgaggta  ttcagagag  840
tgggaatga  ttgcacatg  catataaaa  aggacttgt  gaagctcta  gtggatttc  900
gttcacatt  aagcacctt  atggacgtc  gattgtggt  aaatacccc  ctggcaaag  960
aattgaacc  gggtgtgtt  gtgtagttc  aggtgaagg  atgccgcag  atcgtaatc  1020
ctttgaaaa  ggtgatctt  acataaagt  tgatgtgca  tttcctgaa  acaactgga  1080
caacccaga  aagctttct  aactagaag  tcttctgcc  tctagaccg  aagttccta  1140
cataattgg  gaaacagag  aggtagagc  tcaggaatt  gatagcact  gaggctcag  1200
aggtggtca  aggcgtgaa  cctataatg  tagctctga  gaagaaagc  gcagccatc  1260
tggacctgg  gtgcagtgt  cccatcagt  aactctgca  acaaattgc  caggtggat  1320
ttctttcca  atttgcctg  tttgttctc  gcaatccag  tggagtgtc  tatcaatcc  1380
agatgaact  agggacatc  gttggtcta  gtataactt  taaaattgg  atagtatct  1440
cagagtgta  aatttaaac  aaccacaaa  ctttacatc  tcattttga  tgttccata  1500
caaaataaa  cacttgaaa  gaaacaaaa  tccctttca  acatggatt  ttataagtt  1560
caatcctgg  atctgtgct  gatttttat  agttttgtg  aaattttta  gtttcatat  1620
ttaaattta  atcccacat  gtaaagttt  tacaatttg  cctgaagct  tgtgtttgg  1680
tgcacctgc  taagctgct  caaataaaa  aaaaaattt  atagcctgt  tctatcatt  1740
aaatgcatg  aaaaaaatg  gctttgcac  caatgggtt  ggagctgac  gggaacaat  1800
gaaaaaatt  cattagctg  ggttgtaaa  tttttttgt  tttgggttt  gtttttttt  1860
tgttttttt  ttttttttt  ttaccattt  gtgaaaggt  tttgaaaat  gataataaa  1920
agcggttgg  gtaaattta  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1980
aaaaaaaaa  aaa  1993



<210> 6937
<211> 412
<212> PRT
<213> Homo sapiens
<308> O60884
<400> 6937

Met Ala Asn Val Ala Asp Thr Lys Leu Tyr Asp Ile Leu Gly Val Pro 
  1               5                  10                  15
Pro Gly Ala Ser Glu Asn Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala 
             20                  25                  30
Lys Glu Tyr His Pro Asp Lys Asn Pro Asn Ala Gly Asp Lys Phe Lys 
         35                  40                  45
Glu Ile Ser Phe Ala Tyr Glu Val Leu Ser Asn Pro Glu Lys Arg Glu 
     50                  55                  60
Leu Tyr Asp Arg Tyr Gly Glu Gln Gly Leu Arg Glu Gly Ser Gly Gly 
 65                  70                  75                  80
Gly Gly Gly Met Asp Asp Ile Phe Ser His Ile Phe Gly Gly Gly Leu 
                 85                  90                  95
Phe Gly Phe Met Gly Asn Gln Ser Arg Ser Arg Asn Gly Arg Arg Arg 
             100                105                110
Gly Glu Asp Met Met His Pro Leu Lys Val Ser Leu Glu Asp Leu Tyr 
         115                120                125
Asn Gly Lys Thr Thr Lys Leu Gln Leu Ser Lys Asn Val Leu Cys Ser 
     130                135                140
Ala Cys Ser Gly Gln Gly Gly Lys Ser Gly Ala Val Gln Lys Cys Ser 
 145                150                155                160
Ala Cys Arg Gly Arg Gly Val Arg Ile Met Ile Arg Gln Leu Ala Pro 
                 165                170                175
Gly Met Val Gln Gln Met Gln Ser Val Cys Ser Asp Cys Asn Gly Glu 
             180                185                190
Gly Glu Val Ile Asn Glu Lys Asp Arg Cys Lys Lys Cys Glu Gly Lys 
         195                200                205
Lys Val Ile Lys Glu Val Lys Ile Leu Glu Val His Val Asp Lys Gly 
     210                215                220
Met Lys His Gly Gln Arg Ile Thr Phe Thr Gly Glu Ala Asp Gln Ala 
 225                230                235                240
Pro Gly Val Glu Pro Gly Asp Ile Val Leu Leu Leu Gln Glu Lys Glu 
                 245                250                255
His Glu Val Phe Gln Arg Asp Gly Asn Asp Leu His Met Thr Tyr Lys 
             260                265                270
Ile Gly Leu Val Glu Ala Leu Cys Gly Phe Gln Phe Thr Phe Lys His 
         275                280                285
Leu Asp Gly Arg Gln Ile Val Val Lys Tyr Pro Pro Gly Lys Val Ile 
     290                295                300
Glu Pro Gly Cys Val Arg Val Val Arg Gly Glu Gly Met Pro Gln Tyr 
 305                310                315                320
Arg Asn Pro Phe Glu Lys Gly Asp Leu Tyr Ile Lys Phe Asp Val Gln 
                 325                330                335
Phe Pro Glu Asn Asn Trp Ile Asn Pro Asp Lys Leu Ser Glu Leu Glu 
             340                345                350
Asp Leu Leu Pro Ser Arg Pro Glu Val Pro Asn Ile Ile Gly Glu Thr 
         355                360                365
Glu Glu Val Glu Leu Gln Glu Phe Asp Ser Thr Arg Gly Ser Gly Gly 
     370                375                380
Gly Gln Arg Arg Glu Ala Tyr Asn Asp Ser Ser Asp Glu Glu Ser Ser 
 385                390                395                400
Ser His His Gly Pro Gly Val Gln Cys Ala His Gln 
                 405                410



<210> 6938
<211> 596
<212> DNA
<213> Rattus norvegicus
<308> AI171167
<400> 6938

caagttttt  ttttctgtt  tgttcgtac  aaaaaaaga  aatctagaa  gatttagtg  60
attcaaatc  ctacaaaac  caaacgagg  aataatctg  taaagacat  gagcacatt  120
taatttcta  ttctaaatc  ccacgtatg  cttaaaagc  ttgaaagta  aagtttaag  180
catcaaaat  actaattat  gacgataat  acagtctgg  tcctaggag  caactggag  240
cgttttaat  ggaaataag  atttgagat  atgttaata  cagtgcaga  aaatgaagt  300
aaaaacaaa  tcagtgtta  gaagccttc  gtcctgcac  ttgctttta  tcatctcct  360
cacagagaa  gagcagaac  ttcctgtag  ctccagaag  gtcgccctt  ataaaagag  420
acaaagact  cccgtagag  ctcttgaag  ttgcccgga  gtccagcat  tcaatctct  480
ctcgagaca  catcactct  atgagggtg  tgtcgtcag  gcctaagcc  ttcatggat  540
tataaagcc  ttcagcana  taggcaggt  tattcctca  gcacttcac  atagcc  596



<210> 6939
<211> 318
<212> PRT
<213> Rattus norvegicus
<308> P55260
<400> 6939

Glu Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe Asn Ala Thr 
  1               5                  10                  15
Glu Asp Ala Gln Val Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp 
             20                  25                  30
Glu Asp Ala Ile Ile Gly Val Leu Ala Cys Arg Asn Thr Ala Gln Arg 
         35                  40                  45
Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg Asp Leu Leu 
     50                  55                  60
Glu Asp Leu Lys Ser Glu Leu Ser Ser Asn Phe Glu Gln Val Ile Leu 
 65                  70                  75                  80
Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu Leu Arg Arg 
                 85                  90                  95
Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile Glu Ile Leu 
             100                105                110
Ala Ser Arg Asn Pro Glu Glu Ile Arg Arg Ile Asn Gln Thr Tyr Gln 
         115                120                125
Gln Gln Tyr Gly Arg Ser Leu Glu Glu Asp Ile Cys Ser Asp Thr Ser 
     130                135                140
Phe Met Phe Gln Arg Val Leu Val Ser Leu Thr Ala Gly Gly Arg Asp 
 145                150                155                160
Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp Ala Gln Asp 
                 165                170                175
Leu Tyr Glu Ala Gly Glu Lys Arg Trp Gly Thr Asp Glu Val Lys Phe 
             180                185                190
Leu Ser Ile Leu Cys Ser Arg Asn Arg Asn His Leu Leu His Val Phe 
         195                200                205
Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln Ser Ile Lys 
     210                215                220
Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala Ile Val Lys 
 225                230                235                240
Cys Met Arg Asn Lys Pro Ala Tyr Phe Ala Glu Arg Leu Tyr Lys Ser 
                 245                250                255
Met Lys Gly Leu Gly Thr Asp Asp Ser Thr Leu Ile Arg Val Met Val 
             260                265                270
Ser Arg Pro Glu Ile Asp Met Leu Asp Ile Pro Ala Asn Phe Lys Arg 
         275                280                285
Val Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp Thr Ser Gly 
     290                295                300
Asp Tyr Arg Lys Val Leu Leu Ile Leu Cys Gly Gly Asp Asp 
 305                310                315



<210> 6940
<211> 1976
<212> DNA
<213> Homo sapiens
<308> M82809
<400> 6940

gcagaggag  agcgcacgc  ggcctcgaa  aacttctgc  tgggtggct  aactctgat  60
ttgacctag  gtcatggcc  tggcaacca  aggaggtac  gtcaaagct  cttcaggat  120
caatgccat  gaagatgcc  agaccctga  gaaggccat  aaagggctc  gcaccgatg  180
agacgccat  attagcgtc  ttgcctacc  caacaccgc  cagcgccag  agatcagga  240
agcctacaa  agcaccatc  gcagggact  gatagacga  ctgaagtca  aactgagtg  300
caacttcga  caggtgatt  tggggatga  gacgcccac  gtgctgtat  acgtgcaag  360
gctgcgaag  gccatgaag  gagccggca  tgatgaggg  tgcctaatt  agatcctgg  420
ctcccggac  cctgaggag  tccggcgca  aagccaaac  taccagcag  aatatggac  480
gagccttga  gatgacatt  gctctgaca  atcgttcat  ttccagcga  tgctggtgt  540
tctgtcagc  ggtgggagg  atgaaggaa  ttatctgga  gatgctctc  tgagacagg  600
tgcccagga  ctgtatgag  ctggagaga  gaaatgggg  acagatgag  tgaaatttc  660
aactgttct  tgttcccgg  accgaaatc  cctgttgca  gtgtttgat  aatacaaaa  720
gatatcaca  aaggatatt  aacagagta  taaatctga  acatctggt  gctttgaag  780
tgctctgct  gctatagta  agtgcatga  gaacaaatc  gcatatttt  ctgaaaagc  840
ctataaatc  atgaagggc  tgggcaccg  tgataacac  ctcatcaga  tgatggttt  900
tcgagcaga  attgacatg  tggatatcc  ggcacactt  aagagactc  atggaaagt  960
tctgtactc  ttcatcaag  gtgacacat  tggagacta  aggaaagta  tgcttgttc  1020
ctgtggagg  gatgattaa  ataaaaatc  cagaaggac  ggaggattc  caacacttt  1080
aattttttt  acttcattt  tctacactg  tattatcat  atctcagaa  gcttatttc  1140
aattaaaac  cctacagct  cctcctaga  tatagactg  ctgtattat  attcaccta  1200
aattagtca  tatgatgct  taaagctgt  cttgcattt  aaagcttat  agatataaa  1260
ggagatttt  aagtagaaa  aaatatgta  tccatgttt  taaaagatt  ctttctact  1320
tgtgtttca  agacattga  tatattaaa  tattccata  tttcttttc  gtgaaaaat  1380
ttttaaatg  aagactgtt  taaaatcac  tttttccct  atccaattt  tagagtggc  1440
agtagtttc  tcatttgaa  ttgtaagca  ccggtcagt  agaatgccc  tccagtttt  1500
tatatttca  agtcaaagc  ttgaaagca  ctacaaatc  cttttttta  gttttgtcc  1560
tagcatcag  tgatcctta  taagttttt  atgggagac  tccttcatc  catcttatg  1620
tgaaatcac  ttctgtagt  aaagtatac  aaaaccaat  tatctgaac  aaattctaa  1680
gtatggtta  acaaaccat  tacatctgg  taccaaaca  aaatgctga  cattccata  1740
tattatagt  aatgtctta  tccagcttg  aagtgaatg  aaaaaaaaa  aagcttcaa  1800
ctaggtatt  tgggaatga  gtaatgctc  gaatttagt  tgatataaa  aaaactttt  1860
tgtgctaaa  atacttttt  aaatcaatt  tgttgattg  agtaatttc  atttgcact  1920
tgcctttca  ctccagaaa  attctaaga  gtacttgga  ttaattaaa  agttca  1976



<210> 6941
<211> 318
<212> PRT
<213> Homo sapiens
<308> P09525
<400> 6941

Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe Asn Ala Met 
  1               5                  10                  15
Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp 
             20                  25                  30
Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr Ala Gln Arg 
         35                  40                  45
Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg Asp Leu Ile 
     50                  55                  60
Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln Val Ile Val 
 65                  70                  75                  80
Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu Leu Arg Arg 
                 85                  90                  95
Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile Glu Ile Leu 
             100                105                110
Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln Thr Tyr Gln 
         115                120                125
Gln Gln Tyr Gly Arg Ser Leu Glu Asp Asp Ile Arg Ser Asp Thr Ser 
     130                135                140
Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly Gly Arg Asp 
 145                150                155                160
Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp Ala Gln Asp 
                 165                170                175
Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu Val Lys Phe 
             180                185                190
Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu His Val Phe 
         195                200                205
Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln Ser Ile Lys 
     210                215                220
Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala Ile Val Lys 
 225                230                235                240
Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu Tyr Lys Ser 
                 245                250                255
Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg Val Met Val 
             260                265                270
Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His Phe Lys Arg 
         275                280                285
Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp Thr Ser Gly 
     290                295                300
Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp Asp 
 305                310                315



<210> 6942
<211> 593
<212> DNA
<213> Rattus norvegicus
<308> AI171243
<400> 6942

atattttaa  tttcttttt  ttcagacca  atattgaag  atcgatttt  aaaaattta  60
aaaaagact  agatgtaaa  tgtcatagt  gatttacaa  aaatatata  aaaaaagca  120
attaaatat  agaaattat  ggagtctct  ccttaaact  aaggagtct  ctttaataa  180
tttcaatgt  gcttactgg  aatcttaag  aattcaaga  gctcattca  gttgtgtaa  240
ccctaaagg  aaaaactga  gaaactcat  gataatttt  acagcttca  tgtaaagtt  300
aagatcaaa  cgattacaa  cttccttaa  caggatata  gatgcacat  gtatggttg  360
cttggctgt  accttcccg  ctacttcta  gattccaga  atttcttca  ccagtggct  420
catcaattc  atggttcca  tctttcctt  tccatctga  agaataaac  tttttccag  480
gggatgaat  ttttccagc  tccccacga  gcacacggg  cggtcgata  actgtgata  540
catgctggc  ttgacgcgc  ctttgggga  ttccattat  tccaccatg  ttc  593



<210> 6943
<211> 1175
<212> PRT
<213> Rattus norvegicus
<308> Q62728
<400> 6943

Met Pro Leu Pro Phe Gly Leu Lys Leu Lys Arg Thr Arg Arg Tyr Thr 
  1               5                  10                  15
Val Ser Ser Lys Ser Cys Leu Val Ala Arg Ile Gln Leu Leu Asn Asn 
             20                  25                  30
Glu Phe Val Glu Phe Thr Leu Ser Val Glu Ser Thr Gly Gln Glu Ser 
         35                  40                  45
Leu Glu Ala Val Ala Gln Arg Leu Glu Leu Arg Glu Ile Thr Tyr Phe 
     50                  55                  60
Ser Leu Trp Tyr Tyr Asn Lys Gln Asn Gln Arg Arg Trp Val Asp Leu 
 65                  70                  75                  80
Glu Lys Pro Leu Lys Lys Gln Leu Asp Lys His Ala Leu Glu Pro Thr 
                 85                  90                  95
Val Tyr Phe Gly Val Val Phe Tyr Val Pro Ser Val Ser Gln Leu Gln 
             100                105                110
Gln Glu Ile Thr Arg Tyr Gln Tyr Tyr Leu Gln Leu Lys Lys Asp Val 
         115                120                125
Leu Glu Gly Asn Leu Pro Cys Thr Leu Glu Gln Ala Ile Gln Leu Ala 
     130                135                140
Gly Leu Ala Val Gln Ala Asp Phe Gly Asp Phe Asp Gln Tyr Glu Ser 
 145                150                155                160
Gln Asp Phe Leu Gln Lys Phe Ala Leu Leu Pro Val Gly Trp Leu Gln 
                 165                170                175
Asp Glu Lys Leu Leu Glu Glu Ala Ala Gln Lys Val Ala Leu Leu His 
             180                185                190
Gln Lys Tyr Arg Gly Leu Thr Ala Pro Glu Ala Glu Met Leu Tyr Met 
         195                200                205
Gln Glu Val Glu Arg Met Asp Gly Tyr Gly Glu Glu Ser Tyr Pro Ala 
     210                215                220
Lys Asp Ser Gln Gly Ser Asp Ile Ser Ile Gly Ala Cys Leu Asp Gly 
 225                230                235                240
Ile Phe Val Lys His Lys Asn Gly Arg Pro Pro Val Val Phe Arg Trp 
                 245                250                255
His Asp Ile Ala Asn Met Ser His Asn Lys Ser Phe Phe Ala Leu Glu 
             260                265                270
Leu Ala Asn Lys Glu Glu Thr Ile Gln Phe Gln Thr Glu Asp Met Glu 
         275                280                285
Thr Ala Lys Tyr Val Trp Arg Leu Cys Val Ala Arg His Lys Phe Tyr 
     290                295                300
Arg Leu Asn Gln Cys Asn Leu Gln Thr Gln Ala Ala Thr Leu Asn Ser 
 305                310                315                320
Val Arg Arg Gly Ser Ser Ser Arg Met Ser Leu Pro Lys Pro Gln Pro 
                 325                330                335
Tyr Ala Met Pro Pro Pro Pro Gln Leu His Tyr Asn Gly His Tyr Thr 
             340                345                350
Glu Pro Phe Ala Ser Ser Gln Asp Asn Val Phe Val Pro Asn Lys Asn 
         355                360                365
Gly Phe Tyr Cys His Ser Gln Thr Ser Leu Asp Arg Thr Gln Ile Asp 
     370                375                380
Leu Ser Gly Arg Ile Arg Asn Gly Ser Val Tyr Ser Ala His Ser Thr 
 385                390                395                400
Asn Ser Leu Asn Thr Pro Gln Pro Tyr Leu Gln Pro Ser Pro Met Ser 
                 405                410                415
Ser Asn Pro Ser Ile Pro Gly Ser Asp Val Met Arg Pro Asp Tyr Ile 
             420                425                430
Pro Ser His Arg His Ser Ala Leu Ile Pro Pro Ser Tyr Arg Pro Thr 
         435                440                445
Pro Asp Tyr Glu Ser Val Met Lys Arg Leu Asn Arg Gly Met Val His 
     450                455                460
Ala Asp Arg His Ser His Ser Leu Arg Asn Leu Asn Ile Gly Ser Ser 
 465                470                475                480
Tyr Ala Tyr Ser Arg Pro Asp Ala Leu Val Tyr Ser Gln Pro Glu Ile 
                 485                490                495
Arg Glu His Pro His Leu Ala Ser Pro Gln Ser Ala His Tyr Pro Phe 
             500                505                510
Asn Leu Asn Tyr Ser Phe His Ser Gln Ala Pro Tyr Pro Tyr Pro Val 
         515                520                525
Glu Arg Arg Pro Val Val Gly Ala Val Ser Val Pro Glu Leu Thr Asn 
     530                535                540
Val Gln Leu Gln Ala Gln Asp Tyr Pro Ala Pro Asn Ile Met Arg Thr 
 545                550                555                560
Gln Val Tyr Arg Pro Pro Pro Pro Tyr Pro Tyr Pro Arg Pro Ala Asn 
                 565                570                575
Ser Thr Pro Asp Leu Ser Arg His Leu Tyr Ile Ser Ser Ser Asn Pro 
             580                585                590
Asp Leu Ile Thr Arg Arg Val His His Ser Val Gln Thr Phe Gln Glu 
         595                600                605
Asp Ser Leu Pro Val Ala His Ser Leu Gln Glu Val Ser Glu Pro Leu 
     610                615                620
Thr Ala Ala Arg His Ala His Leu Gln Lys Arg Asn Ser Ile Glu Ile 
 625                630                635                640
Ala Gly Leu Thr His Gly Phe Glu Gly Leu Arg Leu Lys Glu Glu Thr 
                 645                650                655
Met Ser Ala Ser Ala Ala Asp Val Ala Pro Arg Thr Phe Ser Ala Gly 
             660                665                670
Ser Gln Ser Ser Val Phe Ser Asp Lys Val Lys Gln Glu Gly Thr Glu 
         675                680                685
Glu Gln Gly Ser Gly Gly Tyr Ser His Lys Lys Ser Leu Ser Asp Ala 
     690                695                700
Thr Met Leu Ile His Ser Ser Glu Glu Asp Glu Asp Leu Glu Asp Asp 
 705                710                715                720
Ser Ser Arg Glu His Ala Val Ser Glu Pro Arg Leu Thr Ala Ala Phe 
                 725                730                735
Ser Gln Glu Gln Gln Leu Asn Tyr Pro Cys Ala Ser Val Thr Pro Val 
             740                745                750
Thr Gly Pro Leu His Ile Phe Glu Pro Lys Ser His Val Thr Glu Pro 
         755                760                765
Glu Lys Arg Ala Lys Asp Ile Ser Pro Val His Leu Val Met Glu Thr 
     770                775                780
His Gln Pro Arg Arg His Gly Leu Leu Thr Pro Ser Met Ser Glu Ser 
 785                790                795                800
Asp Leu Thr Thr Ser Gly Arg Tyr Arg Ala Arg Arg Asp Ser Leu Lys 
                 805                810                815
Lys Arg Pro Val Ser Asp Leu Leu Ser Gly Lys Lys Asn Thr Val Glu 
             820                825                830
Gly Leu Pro Pro Leu Gly Gly Met Lys Lys Thr Arg Ala Asp Ala Lys 
         835                840                845
Lys Ile Gly Pro Leu Lys Leu Ala Ala Leu Asn Gly Leu Ser Leu Ser 
     850                855                860
Arg Leu Pro Leu Pro Asp Glu Gly Lys Glu Val Ser Thr Arg Ala Thr 
 865                870                875                880
Asn Asp Glu Arg Cys Lys Val Leu Glu Gln Arg Leu Glu Gln Gly Thr 
                 885                890                895
Val Phe Thr Glu Tyr Glu Arg Ile Leu Lys Lys Arg Leu Val Asp Gly 
             900                905                910
Glu Cys Ser Thr Ala Arg Leu Pro Glu Asn Ala Glu Arg Asn Arg Phe 
         915                920                925
Gln Asp Val Leu Pro Tyr Asp Asp Ala Arg Val Glu Leu Val Pro Thr 
     930                935                940
Lys Glu Asn Asn Thr Gly Tyr Ile Asn Ala Ser His Ile Lys Val Ser 
 945                950                955                960
Val Ser Gly Ile Glu Trp Asp Tyr Ile Ala Thr Gln Gly Pro Leu Gln 
                 965                970                975
Asn Thr Cys Gln Asp Phe Trp Gln Met Val Trp Glu Gln Gly Val Ala 
             980                985                990
Ile Ile Ala Met Val Thr Ala Glu Glu Glu Gly Gly Arg Glu Lys Ser 
         995                1000                1005
Phe Arg Tyr Trp Pro Arg Leu Gly Ser Arg His Asn Thr Val Thr Tyr 
     1010                1015                1020
Gly Arg Phe Lys Ile Thr Thr Arg Phe Arg Thr Asp Ser Gly Cys Tyr 
 1025                1030                1035                1040
Ala Thr Thr Gly Leu Lys Met Lys His Leu Leu Thr Gly Gln Glu Arg 
                 1045                1050                1055
Thr Val Trp His Leu Gln Tyr Thr Asp Trp Pro Glu His Gly Cys Pro 
             1060                1065                1070
Glu Asp Leu Lys Gly Phe Leu Ser Tyr Leu Glu Glu Ile Gln Ser Val 
         1075                1080                1085
Arg Arg His Thr Asn Ser Thr Ser Glu Pro Arg Ser Pro Asn Pro Pro 
     1090                1095                1100
Leu Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Val Val Ile 
 1105                1110                1115                1120
Leu Ser Glu Ile Met Val Ala Cys Leu Glu His Asn Glu Val Leu Asp 
                 1125                1130                1135
Ile Pro Arg Val Leu Glu Leu Leu Arg Gln Gln Arg Met Met Leu Val 
             1140                1145                1150
Gln Thr Leu Ser Gln Tyr Thr Phe Val Tyr Arg Val Leu Ile Gln Phe 
         1155                1160                1165
Leu Lys Ser Ser Arg Leu Ile 
     1170                1175



<210> 6944
<211> 3309
<212> DNA
<213> Homo sapiens
<308> AF069072
<400> 6944

gcggcgcgc  cgagcctag  ccccacgcc  cggcgcgcc  gggctccct  ctgatccca  60
aacaatcaa  catgacgac  gaatctgga  cagactcgg  atccaagcc  gaccaggag  120
ccgagcccc  ggaggcggc  ggggcgcag  ggcggcggg  gccgtgccg  agccgccca  180
ggaggagca  cagcaggcc  tggagcagt  cgccgccgc  gcagcgcac  gcaccccgg  240
gcgagggag  tcactgaca  ggaacagga  tttgctgcc  gggctgcaa  acagctcga  300
tatcagcaa  tagaagacg  taaactttc  cagaaatca  ctagcagta  actctctcg  360
tctccatta  agattgtca  aaagcctaa  agcatgcag  gcaaagtga  acttctcga  420
ggatcagaa  atacctgtg  tgtagagaa  cgctccaga  gacaagtgc  gtttgataa  480
gtgtgtgaa  acttgaact  gctagagaa  gactacttt  ggcttacgt  tcgagatgc  540
gaaaaccag  agaattggt  ggaccctgc  aaggaaata  aaaaacagg  tcgaagtgg  600
gcttggcac  tttcattta  tgtgaaatt  tatccacca  accctgccc  actatctga  660
gatatcacc  ggtactacc  ctgcttgca  ttgcgagat  acatcgtgt  cggaaggct  720
ccctgctcc  ttgttaccc  ggccttgct  ggctcctac  ctgtccagt  agagctcgg  780
gactatgac  cagatgaat  tgggagcga  tacattagt  agttccgct  tgcaccaaa  840
cacactaaa  aactggaag  caaagtgat  gagctgcac  agagccaca  aggaatgac  900
ccagcagaa  cagagatgc  tttcttgga  aatgccaaa  aattatcaa  gtatggggt  960
gatttacat  atgctaagg  ctcagaagg  gtagaaatt  tgttaggag  ttgtgcaag  1020
ggtctgttg  tatatcgcg  ccggctgcg  ataaacaga  ttgcctggc  caaggttct  1080
aagatttca  acaaacgga  caactttta  attaagatc  ggccgggag  gtttgaaca  1140
tttgaaagc  ccattgggt  taagctgcc  aaccatcga  ctgccaagc  tttatggaa  1200
gtatgtgtt  agcatcata  atttttcag  ctactgtta  cagaagcac  tcccaagaa  1260
ttcctaacc  tgggttcca  gtttcgtta  agtggcagg  cacaagcgc  aacgagaag  1320
gccagtgcg  tgatagatc  cccagcacc  tactttgaa  gctcatcca  caaacgtta  1380
accatgtct  gcagcttgg  tggagcatc  gtgaatgaa  accatgaaa  atacatgaa  1440
gattctatg  ctgctgcag  ggttggtac  ggccagtac  ccacaacaa  aggcatctc  1500
cagaccaac  tgatcacca  tgtgactcc  gagaagaag  ctgaggagg  gcgggacga  1560
gaagaggac  aacggagga  gggggaaga  gtcacgccc  tctcggcca  ccagcacga  1620
ggaaagact  acagtgagc  cacggacac  gcagccgac  gggagacca  tgccactga  1680
gagctagaa  aaactcaag  tgacctgat  aaacatcaa  ccaacatta  cgagctgaa  1740
agaaccttc  tagaaacct  aacagacac  gccgtaacg  atgaatggg  gaagaggct  1800
tccacctcc  ccgtgcgac  ggccgccag  caggaggat  cccccatga  cgaaccact  1860
gtccctgaa  agaaaatgg  aaccaagac  gagtccagt  gatagagac  gaacccacc  1920
tgcaccacc  gccgcttag  actgagaag  tggtgcagg  gaccgtgtt  gtggaggag  1980
ggcgtgtgg  gcacgcgag  ggggatgct  cttactcgg  gggagacag  ggggatgct  2040
cagcacagc  cgcattcac  ggcattaaa  ggaaagagg  ctctgcttg  cggaggggg  2100
taaagagga  ggaggggag  aggtcgcta  agctgtcct  gaacaggaa  agacagccg  2160
tgcttcccg  gagcgacaa  aggagcaga  tgcagccat  cacatttca  aaactttgg  2220
acaaaaacc  cattttgag  cctcaacgg  gaagacgga  accatcagt  ttggcagtg  2280
ttcaccggg  ggagtaaag  tagaaattt  cacaagaag  gccagtagt  cacaccgaa  2340
ccaaaacca  cacatatga  tcatcacag  tcgatccag  cacagatct  gagccaggc  2400
tgctgatga  tgcacagac  atcacatct  aaaccacca  taccaccac  actacccac  2460
tcaccaaaa  tgtgaaagg  ggcatttca  agacaagaa  tgagaagcg  atagtcatc  2520
cgggggatg  agacattga  catgaccag  cgctggctc  ggcaattaa  gaggccaaa  2580
agcagcacc  tgacatgtc  gtgaccaaa  tagtggtcc  taaagagac  gagatcaca  2640
cagaagatg  agaggattg  ccagaggaa  aacttagct  gcacatgaa  gcagtcatg  2700
aaaccgtta  gaaaaccag  gcctatatg  agttccctc  tctaaccca  ctgtacttg  2760
atctgtccg  ggaaaattt  agtccagaa  aattgacct  gaccattaa  aaagacact  2820
gcagagaga  cttcccata  taaagcaat  tgattcagc  tcactaaac  gataatgca  2880
gaagcaacg  taaaattac  aaagagcag  atttttaat  ttcacaaaa  gtctcagtt  2940
tcagctata  ctgctcgtt  ataaccaac  atataaacc  tggtctcat  taacacata  3000
acaattcat  cctttcata  tttattatt  ttaaagtct  aacaaaatt  caatttctt  3060
ggtaacctt  tatttacaa  aaatgaaga  taccctcaa  tgctagaag  tgtctaggt  3120
cgtccggtg  gtcagattt  ctcagatta  atgtgccaa  aaccaagtt  attcagtaa  3180
caacttgta  ttgtttcat  tggtttatt  ctctcaccc  taaacagta  tgactctct  3240
accctctgg  aatatgtaa  gcttccaat  ttgctttgt  tatctcatt  aatttgttc  3300
ggttaagga  3309



<210> 6945
<211> 1087
<212> PRT
<213> Homo sapiens
<308> Q9Y2J2
<400> 6945

Met Thr Thr Glu Ser Gly Ser Asp Ser Glu Ser Lys Pro Asp Gln Glu 
  1               5                  10                  15
Ala Glu Pro Gln Glu Ala Ala Gly Ala Gln Gly Arg Ala Gly Ala Pro 
             20                  25                  30
Val Pro Glu Pro Pro Lys Glu Glu Gln Gln Gln Ala Leu Glu Gln Phe 
         35                  40                  45
Ala Ala Ala Ala Ala His Ser Thr Pro Val Arg Arg Glu Val Thr Asp 
     50                  55                  60
Lys Glu Gln Glu Phe Ala Ala Arg Ala Ala Lys Gln Leu Glu Tyr Gln 
 65                  70                  75                  80
Gln Leu Glu Asp Asp Lys Leu Ser Gln Lys Ser Ser Ser Ser Lys Leu 
                 85                  90                  95
Ser Arg Ser Pro Leu Lys Ile Val Lys Lys Pro Lys Ser Met Gln Cys 
             100                105                110
Lys Val Ile Leu Leu Asp Gly Ser Glu Tyr Thr Cys Asp Val Glu Lys 
         115                120                125
Arg Ser Arg Gly Gln Val Leu Phe Asp Lys Val Cys Glu His Leu Asn 
     130                135                140
Leu Leu Glu Lys Asp Tyr Phe Gly Leu Thr Tyr Arg Asp Ala Glu Asn 
 145                150                155                160
Gln Lys Asn Trp Leu Asp Pro Ala Lys Glu Ile Lys Lys Gln Val Arg 
                 165                170                175
Ser Gly Ala Trp His Phe Ser Phe Asn Val Lys Phe Tyr Pro Pro Asp 
             180                185                190
Pro Ala Gln Leu Ser Glu Asp Ile Thr Arg Tyr Tyr Leu Cys Leu Gln 
         195                200                205
Leu Arg Asp Asp Ile Val Ser Gly Arg Leu Pro Cys Ser Phe Val Thr 
     210                215                220
Leu Ala Leu Leu Gly Ser Tyr Thr Val Gln Ser Glu Leu Gly Asp Tyr 
 225                230                235                240
Asp Pro Asp Glu Cys Gly Ser Asp Tyr Ile Ser Glu Phe Arg Phe Ala 
                 245                250                255
Pro Asn His Thr Lys Glu Leu Glu Asp Lys Val Ile Glu Leu His Lys 
             260                265                270
Ser His Arg Gly Met Thr Pro Ala Glu Ala Glu Met His Phe Leu Glu 
         275                280                285
Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp Leu His His Ala Lys 
     290                295                300
Asp Ser Glu Gly Val Glu Ile Met Leu Gly Val Cys Ala Ser Gly Leu 
 305                310                315                320
Leu Ile Tyr Arg Asp Arg Leu Arg Ile Asn Arg Phe Ala Trp Pro Lys 
                 325                330                335
Val Leu Lys Ile Ser Tyr Lys Arg Asn Asn Phe Tyr Ile Lys Ile Arg 
             340                345                350
Pro Gly Glu Phe Glu Gln Phe Glu Ser Thr Ile Gly Phe Lys Leu Pro 
         355                360                365
Asn His Arg Ala Ala Lys Arg Leu Trp Lys Val Cys Val Glu His His 
     370                375                380
Thr Phe Phe Arg Leu Leu Leu Pro Glu Ala Pro Pro Lys Lys Phe Leu 
 385                390                395                400
Thr Leu Gly Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln Ala Gln Thr 
                 405                410                415
Arg Arg Ala Ser Ala Leu Ile Asp Arg Pro Ala Pro Tyr Phe Glu Arg 
             420                425                430
Ser Ser Ser Lys Arg Tyr Thr Met Ser Arg Ser Leu Asp Gly Glu Val 
         435                440                445
Gly Thr Gly Gln Tyr Ala Thr Thr Lys Gly Ile Ser Gln Thr Asn Leu 
     450                455                460
Ile Thr Thr Val Thr Pro Glu Lys Lys Ala Glu Glu Glu Arg Asp Glu 
 465                470                475                480
Glu Glu Asp Lys Arg Arg Lys Gly Glu Glu Val Thr Pro Ile Ser Ala 
                 485                490                495
Ile Arg His Glu Gly Lys Ser Pro Gly Leu Gly Thr Asp Ser Cys Pro 
             500                505                510
Leu Ser Pro Pro Ser Thr His Cys Ala Pro Thr Ser Pro Thr Glu Leu 
         515                520                525
Arg Arg Arg Cys Lys Glu Asn Asp Cys Lys Leu Pro Gly Tyr Glu Pro 
     530                535                540
Ser Arg Ala Glu His Leu Pro Gly Glu Pro Ala Leu Asp Ser Asp Gly 
 545                550                555                560
Pro Gly Arg Pro Tyr Leu Gly Asp Gln Asp Val Ala Phe Ser Tyr Arg 
                 565                570                575
Gln Gln Thr Gly Lys Gly Thr Thr Leu Phe Ser Phe Ser Leu Gln Leu 
             580                585                590
Pro Glu Ser Phe Pro Ser Leu Leu Asp Asp Asp Gly Tyr Leu Ser Phe 
         595                600                605
Pro Asn Leu Ser Glu Thr Asn Leu Leu Pro Gln Ser Leu Gln His Tyr 
     610                615                620
Leu Pro Ile Arg Ser Pro Ser Leu Val Pro Cys Phe Leu Phe Ile Phe 
 625                630                635                640
Phe Phe Leu Leu Ser Ala Ser Phe Ser Val Pro Tyr Ala Leu Thr Leu 
                 645                650                655
Ser Phe Pro Leu Ala Leu Cys Leu Cys Tyr Leu Glu Pro Lys Ala Ala 
             660                665                670
Ser Leu Ser Ala Ser Leu Asp Asn Asp Pro Ser Asp Ser Ser Glu Glu 
         675                680                685
Glu Thr Asp Ser Glu Arg Thr Asp Thr Ala Ala Asp Gly Glu Thr Thr 
     690                695                700
Ala Thr Glu Ser Asp Gln Glu Glu Asp Ala Glu Leu Lys Ala Gln Glu 
 705                710                715                720
Leu Glu Lys Thr Gln Asp Asp Leu Met Lys His Gln Thr Asn Ile Ser 
                 725                730                735
Glu Leu Lys Arg Thr Phe Leu Glu Thr Ser Thr Asp Thr Ala Val Thr 
             740                745                750
Asn Glu Trp Glu Lys Arg Leu Ser Thr Ser Pro Val Arg Leu Ala Ala 
         755                760                765
Arg Gln Glu Asp Ala Pro Met Ile Glu Pro Leu Val Pro Glu Glu Thr 
     770                775                780
Lys Gln Ser Ser Gly Glu Lys Leu Met Asp Gly Ser Glu Ile Phe Ser 
 785                790                795                800
Leu Leu Glu Ser Ala Arg Lys Pro Thr Glu Phe Ile Gly Gly Val Thr 
                 805                810                815
Ser Thr Ser Gln Ser Trp Val Gln Lys Met Glu Thr Lys Thr Glu Ser 
             820                825                830
Ser Gly Ile Glu Thr Glu Pro Thr Val His His Leu Pro Leu Ser Thr 
         835                840                845
Glu Lys Val Val Gln Glu Thr Val Leu Val Glu Glu Arg Arg Val Val 
     850                855                860
His Ala Ser Gly Asp Ala Ser Tyr Ser Ala Gly Asp Ser Gly Asp Ala 
 865                870                875                880
Ala Ala Gln Pro Ala Phe Thr Gly Ile Lys Gly Lys Glu Gly Ser Ala 
                 885                890                895
Leu Thr Glu Gly Ala Lys Glu Glu Gly Gly Glu Glu Val Ala Lys Ala 
             900                905                910
Val Leu Glu Gln Glu Glu Thr Ala Ala Ala Ser Arg Glu Arg Gln Glu 
         915                920                925
Glu Gln Ser Ala Ala Ile His Ile Ser Glu Thr Leu Glu Gln Lys Pro 
     930                935                940
His Phe Glu Ser Ser Thr Val Lys Thr Glu Thr Ile Ser Phe Gly Ser 
 945                950                955                960
Val Ser Pro Gly Gly Val Lys Leu Glu Ile Ser Thr Lys Glu Val Pro 
                 965                970                975
Val Val His Thr Glu Thr Lys Thr Ile Thr Tyr Glu Ser Ser Gln Val 
             980                985                990
Asp Pro Gly Thr Asp Leu Glu Pro Gly Val Leu Met Ser Ala Gln Thr 
         995                1000                1005
Ile Thr Ser Glu Thr Thr Ser Thr Thr Thr Thr Thr His Ile Thr Lys 
     1010                1015                1020
Thr Val Lys Gly Gly Ile Ser Glu Thr Arg Ile Glu Lys Arg Ile Val 
 1025                1030                1035                1040
Ile Thr Gly Asp Ala Asp Ile Asp His Asp Gln Ala Leu Ala Gln Ala 
                 1045                1050                1055
Ile Lys Glu Ala Lys Glu Gln His Pro Asp Met Ser Val Thr Lys Val 
             1060                1065                1070
Val Val His Lys Glu Thr Glu Ile Thr Pro Glu Asp Gly Glu Asp 
         1075                1080                1085



<210> 6946
<211> 593
<212> DNA
<213> Rattus norvegicus
<308> AI171243
<400> 6946

atattttaa  tttcttttt  ttcagacca  atattgaag  atcgatttt  aaaaattta  60
aaaaagact  agatgtaaa  tgtcatagt  gatttacaa  aaatatata  aaaaaagca  120
attaaatat  agaaattat  ggagtctct  ccttaaact  aaggagtct  ctttaataa  180
tttcaatgt  gcttactgg  aatcttaag  aattcaaga  gctcattca  gttgtgtaa  240
ccctaaagg  aaaaactga  gaaactcat  gataatttt  acagcttca  tgtaaagtt  300
aagatcaaa  cgattacaa  cttccttaa  caggatata  gatgcacat  gtatggttg  360
cttggctgt  accttcccg  ctacttcta  gattccaga  atttcttca  ccagtggct  420
catcaattc  atggttcca  tctttcctt  tccatctga  agaataaac  tttttccag  480
gggatgaat  ttttccagc  tccccacga  gcacacggg  cggtcgata  actgtgata  540
catgctggc  ttgacgcgc  ctttgggga  ttccattat  tccaccatg  ttc  593



<210> 6947
<211> 1175
<212> PRT
<213> Rattus norvegicus
<308> Q62728
<400> 6947

Met Pro Leu Pro Phe Gly Leu Lys Leu Lys Arg Thr Arg Arg Tyr Thr 
  1               5                  10                  15
Val Ser Ser Lys Ser Cys Leu Val Ala Arg Ile Gln Leu Leu Asn Asn 
             20                  25                  30
Glu Phe Val Glu Phe Thr Leu Ser Val Glu Ser Thr Gly Gln Glu Ser 
         35                  40                  45
Leu Glu Ala Val Ala Gln Arg Leu Glu Leu Arg Glu Ile Thr Tyr Phe 
     50                  55                  60
Ser Leu Trp Tyr Tyr Asn Lys Gln Asn Gln Arg Arg Trp Val Asp Leu 
 65                  70                  75                  80
Glu Lys Pro Leu Lys Lys Gln Leu Asp Lys His Ala Leu Glu Pro Thr 
                 85                  90                  95
Val Tyr Phe Gly Val Val Phe Tyr Val Pro Ser Val Ser Gln Leu Gln 
             100                105                110
Gln Glu Ile Thr Arg Tyr Gln Tyr Tyr Leu Gln Leu Lys Lys Asp Val 
         115                120                125
Leu Glu Gly Asn Leu Pro Cys Thr Leu Glu Gln Ala Ile Gln Leu Ala 
     130                135                140
Gly Leu Ala Val Gln Ala Asp Phe Gly Asp Phe Asp Gln Tyr Glu Ser 
 145                150                155                160
Gln Asp Phe Leu Gln Lys Phe Ala Leu Leu Pro Val Gly Trp Leu Gln 
                 165                170                175
Asp Glu Lys Leu Leu Glu Glu Ala Ala Gln Lys Val Ala Leu Leu His 
             180                185                190
Gln Lys Tyr Arg Gly Leu Thr Ala Pro Glu Ala Glu Met Leu Tyr Met 
         195                200                205
Gln Glu Val Glu Arg Met Asp Gly Tyr Gly Glu Glu Ser Tyr Pro Ala 
     210                215                220
Lys Asp Ser Gln Gly Ser Asp Ile Ser Ile Gly Ala Cys Leu Asp Gly 
 225                230                235                240
Ile Phe Val Lys His Lys Asn Gly Arg Pro Pro Val Val Phe Arg Trp 
                 245                250                255
His Asp Ile Ala Asn Met Ser His Asn Lys Ser Phe Phe Ala Leu Glu 
             260                265                270
Leu Ala Asn Lys Glu Glu Thr Ile Gln Phe Gln Thr Glu Asp Met Glu 
         275                280                285
Thr Ala Lys Tyr Val Trp Arg Leu Cys Val Ala Arg His Lys Phe Tyr 
     290                295                300
Arg Leu Asn Gln Cys Asn Leu Gln Thr Gln Ala Ala Thr Leu Asn Ser 
 305                310                315                320
Val Arg Arg Gly Ser Ser Ser Arg Met Ser Leu Pro Lys Pro Gln Pro 
                 325                330                335
Tyr Ala Met Pro Pro Pro Pro Gln Leu His Tyr Asn Gly His Tyr Thr 
             340                345                350
Glu Pro Phe Ala Ser Ser Gln Asp Asn Val Phe Val Pro Asn Lys Asn 
         355                360                365
Gly Phe Tyr Cys His Ser Gln Thr Ser Leu Asp Arg Thr Gln Ile Asp 
     370                375                380
Leu Ser Gly Arg Ile Arg Asn Gly Ser Val Tyr Ser Ala His Ser Thr 
 385                390                395                400
Asn Ser Leu Asn Thr Pro Gln Pro Tyr Leu Gln Pro Ser Pro Met Ser 
                 405                410                415
Ser Asn Pro Ser Ile Pro Gly Ser Asp Val Met Arg Pro Asp Tyr Ile 
             420                425                430
Pro Ser His Arg His Ser Ala Leu Ile Pro Pro Ser Tyr Arg Pro Thr 
         435                440                445
Pro Asp Tyr Glu Ser Val Met Lys Arg Leu Asn Arg Gly Met Val His 
     450                455                460
Ala Asp Arg His Ser His Ser Leu Arg Asn Leu Asn Ile Gly Ser Ser 
 465                470                475                480
Tyr Ala Tyr Ser Arg Pro Asp Ala Leu Val Tyr Ser Gln Pro Glu Ile 
                 485                490                495
Arg Glu His Pro His Leu Ala Ser Pro Gln Ser Ala His Tyr Pro Phe 
             500                505                510
Asn Leu Asn Tyr Ser Phe His Ser Gln Ala Pro Tyr Pro Tyr Pro Val 
         515                520                525
Glu Arg Arg Pro Val Val Gly Ala Val Ser Val Pro Glu Leu Thr Asn 
     530                535                540
Val Gln Leu Gln Ala Gln Asp Tyr Pro Ala Pro Asn Ile Met Arg Thr 
 545                550                555                560
Gln Val Tyr Arg Pro Pro Pro Pro Tyr Pro Tyr Pro Arg Pro Ala Asn 
                 565                570                575
Ser Thr Pro Asp Leu Ser Arg His Leu Tyr Ile Ser Ser Ser Asn Pro 
             580                585                590
Asp Leu Ile Thr Arg Arg Val His His Ser Val Gln Thr Phe Gln Glu 
         595                600                605
Asp Ser Leu Pro Val Ala His Ser Leu Gln Glu Val Ser Glu Pro Leu 
     610                615                620
Thr Ala Ala Arg His Ala His Leu Gln Lys Arg Asn Ser Ile Glu Ile 
 625                630                635                640
Ala Gly Leu Thr His Gly Phe Glu Gly Leu Arg Leu Lys Glu Glu Thr 
                 645                650                655
Met Ser Ala Ser Ala Ala Asp Val Ala Pro Arg Thr Phe Ser Ala Gly 
             660                665                670
Ser Gln Ser Ser Val Phe Ser Asp Lys Val Lys Gln Glu Gly Thr Glu 
         675                680                685
Glu Gln Gly Ser Gly Gly Tyr Ser His Lys Lys Ser Leu Ser Asp Ala 
     690                695                700
Thr Met Leu Ile His Ser Ser Glu Glu Asp Glu Asp Leu Glu Asp Asp 
 705                710                715                720
Ser Ser Arg Glu His Ala Val Ser Glu Pro Arg Leu Thr Ala Ala Phe 
                 725                730                735
Ser Gln Glu Gln Gln Leu Asn Tyr Pro Cys Ala Ser Val Thr Pro Val 
             740                745                750
Thr Gly Pro Leu His Ile Phe Glu Pro Lys Ser His Val Thr Glu Pro 
         755                760                765
Glu Lys Arg Ala Lys Asp Ile Ser Pro Val His Leu Val Met Glu Thr 
     770                775                780
His Gln Pro Arg Arg His Gly Leu Leu Thr Pro Ser Met Ser Glu Ser 
 785                790                795                800
Asp Leu Thr Thr Ser Gly Arg Tyr Arg Ala Arg Arg Asp Ser Leu Lys 
                 805                810                815
Lys Arg Pro Val Ser Asp Leu Leu Ser Gly Lys Lys Asn Thr Val Glu 
             820                825                830
Gly Leu Pro Pro Leu Gly Gly Met Lys Lys Thr Arg Ala Asp Ala Lys 
         835                840                845
Lys Ile Gly Pro Leu Lys Leu Ala Ala Leu Asn Gly Leu Ser Leu Ser 
     850                855                860
Arg Leu Pro Leu Pro Asp Glu Gly Lys Glu Val Ser Thr Arg Ala Thr 
 865                870                875                880
Asn Asp Glu Arg Cys Lys Val Leu Glu Gln Arg Leu Glu Gln Gly Thr 
                 885                890                895
Val Phe Thr Glu Tyr Glu Arg Ile Leu Lys Lys Arg Leu Val Asp Gly 
             900                905                910
Glu Cys Ser Thr Ala Arg Leu Pro Glu Asn Ala Glu Arg Asn Arg Phe 
         915                920                925
Gln Asp Val Leu Pro Tyr Asp Asp Ala Arg Val Glu Leu Val Pro Thr 
     930                935                940
Lys Glu Asn Asn Thr Gly Tyr Ile Asn Ala Ser His Ile Lys Val Ser 
 945                950                955                960
Val Ser Gly Ile Glu Trp Asp Tyr Ile Ala Thr Gln Gly Pro Leu Gln 
                 965                970                975
Asn Thr Cys Gln Asp Phe Trp Gln Met Val Trp Glu Gln Gly Val Ala 
             980                985                990
Ile Ile Ala Met Val Thr Ala Glu Glu Glu Gly Gly Arg Glu Lys Ser 
         995                1000                1005
Phe Arg Tyr Trp Pro Arg Leu Gly Ser Arg His Asn Thr Val Thr Tyr 
     1010                1015                1020
Gly Arg Phe Lys Ile Thr Thr Arg Phe Arg Thr Asp Ser Gly Cys Tyr 
 1025                1030                1035                1040
Ala Thr Thr Gly Leu Lys Met Lys His Leu Leu Thr Gly Gln Glu Arg 
                 1045                1050                1055
Thr Val Trp His Leu Gln Tyr Thr Asp Trp Pro Glu His Gly Cys Pro 
             1060                1065                1070
Glu Asp Leu Lys Gly Phe Leu Ser Tyr Leu Glu Glu Ile Gln Ser Val 
         1075                1080                1085
Arg Arg His Thr Asn Ser Thr Ser Glu Pro Arg Ser Pro Asn Pro Pro 
     1090                1095                1100
Leu Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Val Val Ile 
 1105                1110                1115                1120
Leu Ser Glu Ile Met Val Ala Cys Leu Glu His Asn Glu Val Leu Asp 
                 1125                1130                1135
Ile Pro Arg Val Leu Glu Leu Leu Arg Gln Gln Arg Met Met Leu Val 
             1140                1145                1150
Gln Thr Leu Ser Gln Tyr Thr Phe Val Tyr Arg Val Leu Ile Gln Phe 
         1155                1160                1165
Leu Lys Ser Ser Arg Leu Ile 
     1170                1175



<210> 6948
<211> 3309
<212> DNA
<213> Homo sapiens
<308> AF069072
<400> 6948

gcggcgcgc  cgagcctag  ccccacgcc  cggcgcgcc  gggctccct  ctgatccca  60
aacaatcaa  catgacgac  gaatctgga  cagactcgg  atccaagcc  gaccaggag  120
ccgagcccc  ggaggcggc  ggggcgcag  ggcggcggg  gccgtgccg  agccgccca  180
ggaggagca  cagcaggcc  tggagcagt  cgccgccgc  gcagcgcac  gcaccccgg  240
gcgagggag  tcactgaca  ggaacagga  tttgctgcc  gggctgcaa  acagctcga  300
tatcagcaa  tagaagacg  taaactttc  cagaaatca  ctagcagta  actctctcg  360
tctccatta  agattgtca  aaagcctaa  agcatgcag  gcaaagtga  acttctcga  420
ggatcagaa  atacctgtg  tgtagagaa  cgctccaga  gacaagtgc  gtttgataa  480
gtgtgtgaa  acttgaact  gctagagaa  gactacttt  ggcttacgt  tcgagatgc  540
gaaaaccag  agaattggt  ggaccctgc  aaggaaata  aaaaacagg  tcgaagtgg  600
gcttggcac  tttcattta  tgtgaaatt  tatccacca  accctgccc  actatctga  660
gatatcacc  ggtactacc  ctgcttgca  ttgcgagat  acatcgtgt  cggaaggct  720
ccctgctcc  ttgttaccc  ggccttgct  ggctcctac  ctgtccagt  agagctcgg  780
gactatgac  cagatgaat  tgggagcga  tacattagt  agttccgct  tgcaccaaa  840
cacactaaa  aactggaag  caaagtgat  gagctgcac  agagccaca  aggaatgac  900
ccagcagaa  cagagatgc  tttcttgga  aatgccaaa  aattatcaa  gtatggggt  960
gatttacat  atgctaagg  ctcagaagg  gtagaaatt  tgttaggag  ttgtgcaag  1020
ggtctgttg  tatatcgcg  ccggctgcg  ataaacaga  ttgcctggc  caaggttct  1080
aagatttca  acaaacgga  caactttta  attaagatc  ggccgggag  gtttgaaca  1140
tttgaaagc  ccattgggt  taagctgcc  aaccatcga  ctgccaagc  tttatggaa  1200
gtatgtgtt  agcatcata  atttttcag  ctactgtta  cagaagcac  tcccaagaa  1260
ttcctaacc  tgggttcca  gtttcgtta  agtggcagg  cacaagcgc  aacgagaag  1320
gccagtgcg  tgatagatc  cccagcacc  tactttgaa  gctcatcca  caaacgtta  1380
accatgtct  gcagcttgg  tggagcatc  gtgaatgaa  accatgaaa  atacatgaa  1440
gattctatg  ctgctgcag  ggttggtac  ggccagtac  ccacaacaa  aggcatctc  1500
cagaccaac  tgatcacca  tgtgactcc  gagaagaag  ctgaggagg  gcgggacga  1560
gaagaggac  aacggagga  gggggaaga  gtcacgccc  tctcggcca  ccagcacga  1620
ggaaagact  acagtgagc  cacggacac  gcagccgac  gggagacca  tgccactga  1680
gagctagaa  aaactcaag  tgacctgat  aaacatcaa  ccaacatta  cgagctgaa  1740
agaaccttc  tagaaacct  aacagacac  gccgtaacg  atgaatggg  gaagaggct  1800
tccacctcc  ccgtgcgac  ggccgccag  caggaggat  cccccatga  cgaaccact  1860
gtccctgaa  agaaaatgg  aaccaagac  gagtccagt  gatagagac  gaacccacc  1920
tgcaccacc  gccgcttag  actgagaag  tggtgcagg  gaccgtgtt  gtggaggag  1980
ggcgtgtgg  gcacgcgag  ggggatgct  cttactcgg  gggagacag  ggggatgct  2040
cagcacagc  cgcattcac  ggcattaaa  ggaaagagg  ctctgcttg  cggaggggg  2100
taaagagga  ggaggggag  aggtcgcta  agctgtcct  gaacaggaa  agacagccg  2160
tgcttcccg  gagcgacaa  aggagcaga  tgcagccat  cacatttca  aaactttgg  2220
acaaaaacc  cattttgag  cctcaacgg  gaagacgga  accatcagt  ttggcagtg  2280
ttcaccggg  ggagtaaag  tagaaattt  cacaagaag  gccagtagt  cacaccgaa  2340
ccaaaacca  cacatatga  tcatcacag  tcgatccag  cacagatct  gagccaggc  2400
tgctgatga  tgcacagac  atcacatct  aaaccacca  taccaccac  actacccac  2460
tcaccaaaa  tgtgaaagg  ggcatttca  agacaagaa  tgagaagcg  atagtcatc  2520
cgggggatg  agacattga  catgaccag  cgctggctc  ggcaattaa  gaggccaaa  2580
agcagcacc  tgacatgtc  gtgaccaaa  tagtggtcc  taaagagac  gagatcaca  2640
cagaagatg  agaggattg  ccagaggaa  aacttagct  gcacatgaa  gcagtcatg  2700
aaaccgtta  gaaaaccag  gcctatatg  agttccctc  tctaaccca  ctgtacttg  2760
atctgtccg  ggaaaattt  agtccagaa  aattgacct  gaccattaa  aaagacact  2820
gcagagaga  cttcccata  taaagcaat  tgattcagc  tcactaaac  gataatgca  2880
gaagcaacg  taaaattac  aaagagcag  atttttaat  ttcacaaaa  gtctcagtt  2940
tcagctata  ctgctcgtt  ataaccaac  atataaacc  tggtctcat  taacacata  3000
acaattcat  cctttcata  tttattatt  ttaaagtct  aacaaaatt  caatttctt  3060
ggtaacctt  tatttacaa  aaatgaaga  taccctcaa  tgctagaag  tgtctaggt  3120
cgtccggtg  gtcagattt  ctcagatta  atgtgccaa  aaccaagtt  attcagtaa  3180
caacttgta  ttgtttcat  tggtttatt  ctctcaccc  taaacagta  tgactctct  3240
accctctgg  aatatgtaa  gcttccaat  ttgctttgt  tatctcatt  aatttgttc  3300
ggttaagga  3309



<210> 6949
<211> 1087
<212> PRT
<213> Homo sapiens
<308> Q9Y2J2
<400> 6949

Met Thr Thr Glu Ser Gly Ser Asp Ser Glu Ser Lys Pro Asp Gln Glu 
  1               5                  10                  15
Ala Glu Pro Gln Glu Ala Ala Gly Ala Gln Gly Arg Ala Gly Ala Pro 
             20                  25                  30
Val Pro Glu Pro Pro Lys Glu Glu Gln Gln Gln Ala Leu Glu Gln Phe 
         35                  40                  45
Ala Ala Ala Ala Ala His Ser Thr Pro Val Arg Arg Glu Val Thr Asp 
     50                  55                  60
Lys Glu Gln Glu Phe Ala Ala Arg Ala Ala Lys Gln Leu Glu Tyr Gln 
 65                  70                  75                  80
Gln Leu Glu Asp Asp Lys Leu Ser Gln Lys Ser Ser Ser Ser Lys Leu 
                 85                  90                  95
Ser Arg Ser Pro Leu Lys Ile Val Lys Lys Pro Lys Ser Met Gln Cys 
             100                105                110
Lys Val Ile Leu Leu Asp Gly Ser Glu Tyr Thr Cys Asp Val Glu Lys 
         115                120                125
Arg Ser Arg Gly Gln Val Leu Phe Asp Lys Val Cys Glu His Leu Asn 
     130                135                140
Leu Leu Glu Lys Asp Tyr Phe Gly Leu Thr Tyr Arg Asp Ala Glu Asn 
 145                150                155                160
Gln Lys Asn Trp Leu Asp Pro Ala Lys Glu Ile Lys Lys Gln Val Arg 
                 165                170                175
Ser Gly Ala Trp His Phe Ser Phe Asn Val Lys Phe Tyr Pro Pro Asp 
             180                185                190
Pro Ala Gln Leu Ser Glu Asp Ile Thr Arg Tyr Tyr Leu Cys Leu Gln 
         195                200                205
Leu Arg Asp Asp Ile Val Ser Gly Arg Leu Pro Cys Ser Phe Val Thr 
     210                215                220
Leu Ala Leu Leu Gly Ser Tyr Thr Val Gln Ser Glu Leu Gly Asp Tyr 
 225                230                235                240
Asp Pro Asp Glu Cys Gly Ser Asp Tyr Ile Ser Glu Phe Arg Phe Ala 
                 245                250                255
Pro Asn His Thr Lys Glu Leu Glu Asp Lys Val Ile Glu Leu His Lys 
             260                265                270
Ser His Arg Gly Met Thr Pro Ala Glu Ala Glu Met His Phe Leu Glu 
         275                280                285
Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp Leu His His Ala Lys 
     290                295                300
Asp Ser Glu Gly Val Glu Ile Met Leu Gly Val Cys Ala Ser Gly Leu 
 305                310                315                320
Leu Ile Tyr Arg Asp Arg Leu Arg Ile Asn Arg Phe Ala Trp Pro Lys 
                 325                330                335
Val Leu Lys Ile Ser Tyr Lys Arg Asn Asn Phe Tyr Ile Lys Ile Arg 
             340                345                350
Pro Gly Glu Phe Glu Gln Phe Glu Ser Thr Ile Gly Phe Lys Leu Pro 
         355                360                365
Asn His Arg Ala Ala Lys Arg Leu Trp Lys Val Cys Val Glu His His 
     370                375                380
Thr Phe Phe Arg Leu Leu Leu Pro Glu Ala Pro Pro Lys Lys Phe Leu 
 385                390                395                400
Thr Leu Gly Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln Ala Gln Thr 
                 405                410                415
Arg Arg Ala Ser Ala Leu Ile Asp Arg Pro Ala Pro Tyr Phe Glu Arg 
             420                425                430
Ser Ser Ser Lys Arg Tyr Thr Met Ser Arg Ser Leu Asp Gly Glu Val 
         435                440                445
Gly Thr Gly Gln Tyr Ala Thr Thr Lys Gly Ile Ser Gln Thr Asn Leu 
     450                455                460
Ile Thr Thr Val Thr Pro Glu Lys Lys Ala Glu Glu Glu Arg Asp Glu 
 465                470                475                480
Glu Glu Asp Lys Arg Arg Lys Gly Glu Glu Val Thr Pro Ile Ser Ala 
                 485                490                495
Ile Arg His Glu Gly Lys Ser Pro Gly Leu Gly Thr Asp Ser Cys Pro 
             500                505                510
Leu Ser Pro Pro Ser Thr His Cys Ala Pro Thr Ser Pro Thr Glu Leu 
         515                520                525
Arg Arg Arg Cys Lys Glu Asn Asp Cys Lys Leu Pro Gly Tyr Glu Pro 
     530                535                540
Ser Arg Ala Glu His Leu Pro Gly Glu Pro Ala Leu Asp Ser Asp Gly 
 545                550                555                560
Pro Gly Arg Pro Tyr Leu Gly Asp Gln Asp Val Ala Phe Ser Tyr Arg 
                 565                570                575
Gln Gln Thr Gly Lys Gly Thr Thr Leu Phe Ser Phe Ser Leu Gln Leu 
             580                585                590
Pro Glu Ser Phe Pro Ser Leu Leu Asp Asp Asp Gly Tyr Leu Ser Phe 
         595                600                605
Pro Asn Leu Ser Glu Thr Asn Leu Leu Pro Gln Ser Leu Gln His Tyr 
     610                615                620
Leu Pro Ile Arg Ser Pro Ser Leu Val Pro Cys Phe Leu Phe Ile Phe 
 625                630                635                640
Phe Phe Leu Leu Ser Ala Ser Phe Ser Val Pro Tyr Ala Leu Thr Leu 
                 645                650                655
Ser Phe Pro Leu Ala Leu Cys Leu Cys Tyr Leu Glu Pro Lys Ala Ala 
             660                665                670
Ser Leu Ser Ala Ser Leu Asp Asn Asp Pro Ser Asp Ser Ser Glu Glu 
         675                680                685
Glu Thr Asp Ser Glu Arg Thr Asp Thr Ala Ala Asp Gly Glu Thr Thr 
     690                695                700
Ala Thr Glu Ser Asp Gln Glu Glu Asp Ala Glu Leu Lys Ala Gln Glu 
 705                710                715                720
Leu Glu Lys Thr Gln Asp Asp Leu Met Lys His Gln Thr Asn Ile Ser 
                 725                730                735
Glu Leu Lys Arg Thr Phe Leu Glu Thr Ser Thr Asp Thr Ala Val Thr 
             740                745                750
Asn Glu Trp Glu Lys Arg Leu Ser Thr Ser Pro Val Arg Leu Ala Ala 
         755                760                765
Arg Gln Glu Asp Ala Pro Met Ile Glu Pro Leu Val Pro Glu Glu Thr 
     770                775                780
Lys Gln Ser Ser Gly Glu Lys Leu Met Asp Gly Ser Glu Ile Phe Ser 
 785                790                795                800
Leu Leu Glu Ser Ala Arg Lys Pro Thr Glu Phe Ile Gly Gly Val Thr 
                 805                810                815
Ser Thr Ser Gln Ser Trp Val Gln Lys Met Glu Thr Lys Thr Glu Ser 
             820                825                830
Ser Gly Ile Glu Thr Glu Pro Thr Val His His Leu Pro Leu Ser Thr 
         835                840                845
Glu Lys Val Val Gln Glu Thr Val Leu Val Glu Glu Arg Arg Val Val 
     850                855                860
His Ala Ser Gly Asp Ala Ser Tyr Ser Ala Gly Asp Ser Gly Asp Ala 
 865                870                875                880
Ala Ala Gln Pro Ala Phe Thr Gly Ile Lys Gly Lys Glu Gly Ser Ala 
                 885                890                895
Leu Thr Glu Gly Ala Lys Glu Glu Gly Gly Glu Glu Val Ala Lys Ala 
             900                905                910
Val Leu Glu Gln Glu Glu Thr Ala Ala Ala Ser Arg Glu Arg Gln Glu 
         915                920                925
Glu Gln Ser Ala Ala Ile His Ile Ser Glu Thr Leu Glu Gln Lys Pro 
     930                935                940
His Phe Glu Ser Ser Thr Val Lys Thr Glu Thr Ile Ser Phe Gly Ser 
 945                950                955                960
Val Ser Pro Gly Gly Val Lys Leu Glu Ile Ser Thr Lys Glu Val Pro 
                 965                970                975
Val Val His Thr Glu Thr Lys Thr Ile Thr Tyr Glu Ser Ser Gln Val 
             980                985                990
Asp Pro Gly Thr Asp Leu Glu Pro Gly Val Leu Met Ser Ala Gln Thr 
         995                1000                1005
Ile Thr Ser Glu Thr Thr Ser Thr Thr Thr Thr Thr His Ile Thr Lys 
     1010                1015                1020
Thr Val Lys Gly Gly Ile Ser Glu Thr Arg Ile Glu Lys Arg Ile Val 
 1025                1030                1035                1040
Ile Thr Gly Asp Ala Asp Ile Asp His Asp Gln Ala Leu Ala Gln Ala 
                 1045                1050                1055
Ile Lys Glu Ala Lys Glu Gln His Pro Asp Met Ser Val Thr Lys Val 
             1060                1065                1070
Val Val His Lys Glu Thr Glu Ile Thr Pro Glu Asp Gly Glu Asp 
         1075                1080                1085



<210> 6950
<211> 589
<212> DNA
<213> Rattus norvegicus
<308> AI171268
<400> 6950

aagtgttca  aaattgttt  ttatgcaaa  tgttaactt  tataaaaag  ttaatatac  60
tcacatggt  acagaaagt  accttcctg  aaaaaaaag  tacaaaagc  atatactct  120
ttatagagt  cataatcag  gcaacagag  ttttctcca  ggaaaccag  agaccagct  180
ttatgctgc  ttggcagtg  gtgcagggc  gccactcgt  tacccccca  acccttctc  240
acaccccat  ttcggaaaa  agccagtct  tttaagact  gagtcaggg  ggggacaga  300
tgacgttgc  cagctgctg  ccagcgagt  ctagctagc  cttcaggcc  cccaagttc  360
gtccttcgc  ctcgggctc  aggtccagc  tcgaggcat  agttcaggg  aaatgaaga  420
ggctgtggc  agatcgaag  tcatccatg  ccctcaggc  tccggctgg  gagagggtc  480
cagagtccc  gggtcccaa  cggaacggg  gccagcacc  gcgttcggg  agtgccagg  540
cgaccgggt  agtggcaaa  actcctctt  tccttggag  tcacaagtt  589



<210> 6951
<211> 119
<212> PRT
<213> Rattus norvegicus
<308> P41138
<400> 6951

Met Lys Ala Leu Ser Pro Val Arg Gly Cys Tyr Glu Ala Val Cys Cys 
  1               5                  10                  15
Leu Ser Glu Arg Ser Leu Ala Ile Ala Arg Gly Arg Gly Lys Ser Pro 
             20                  25                  30
Ser Ala Glu Glu Pro Leu Ser Leu Leu Asp Asp Met Asn His Cys Tyr 
         35                  40                  45
Ser Arg Leu Arg Glu Leu Val Pro Gly Val Pro Arg Gly Thr Gln Leu 
     50                  55                  60
Ser Gln Val Glu Ile Leu Gln Arg Val Ile Asp Tyr Ile Leu Asp Leu 
 65                  70                  75                  80
Gln Val Val Leu Ala Glu Pro Ala Pro Gly Pro Pro Asp Gly Pro His 
                 85                  90                  95
Leu Pro Ile Gln Thr Ala Glu Leu Thr Pro Glu Leu Val Ile Ser Lys 
             100                105                110
Asp Lys Arg Ser Phe Cys His 
         115



<210> 6952
<211> 982
<212> DNA
<213> Homo sapiens
<308> X66924
<400> 6952

agacaattt  cagcaggaa  aagtagaaa  gataaaatg  atcctgcac  acgggaacc  60
cacagcacc  cacttcttt  ggttttctt  ctctttggg  cacctctgg  ctcactccc  120
agcatgaag  cgctgagcc  ggtgcgcgg  tgctacgag  cggtgtgct  cctgtcgga  180
cgcagtctg  ccatcgccc  gggccgagg  aagggcccg  cagctgagg  gccgctgag  240
ttgctggac  acatgaacc  ctgctactc  cgcctgcgg  aactggtac  cggagtccc  300
agaggcact  agcttagcc  ggtggaaat  ctacagcgc  tcatcgact  cattctcga  360
ctgcaggta  tcctggccg  gccagcccc  ggaccccct  atggccccc  ccttcccat  420
cagacagcc  agctcgctc  ggaacttgt  atctccaac  acaaaagga  cttttgcca  480
tgactcggc  gtgtcctga  acctccaga  cgcaggtgc  ggcgcccgt  ctgcctggg  540
ccccgggaa  ctctcctgc  ggaagccgg  cggcaggga  gggccccaa  ttcgccctg  600
ccacttgac  tcaccaaat  ccttcctgg  gactgaacc  ggtgctcag  agcgaagga  660
tgtgaactt  tggcctgaa  agccagagc  agctctggc  accagctgg  cgacgtcac  720
ctgctccca  cccacccca  gttctaagg  cttttcaga  cgtggaggt  tggaaggag  780
ggctgctct  caaactatg  caaggcggc  gcagagctg  tcttctggt  tccttggag  840
aaggttctg  tgccctgat  tatgaactc  ataatagag  atataggtt  tgtaccttt  900
ttacaggaa  gtgactttc  gtaacaatg  gatgtatat  aaacttttt  taaaagtta  960
cattttgca  aataaacga  tt  982



<210> 6953
<211> 119
<212> PRT
<213> Homo sapiens
<308> Q02535
<400> 6953

Met Lys Ala Leu Ser Pro Val Arg Gly Cys Tyr Glu Ala Val Cys Cys 
  1               5                  10                  15
Leu Ser Glu Arg Ser Leu Ala Ile Ala Arg Gly Arg Gly Lys Gly Pro 
             20                  25                  30
Ala Ala Glu Glu Pro Leu Ser Leu Leu Asp Asp Met Asn His Cys Tyr 
         35                  40                  45
Ser Arg Leu Arg Glu Leu Val Pro Gly Val Pro Arg Gly Thr Gln Leu 
     50                  55                  60
Ser Gln Val Glu Ile Leu Gln Arg Val Ile Asp Tyr Ile Leu Asp Leu 
 65                  70                  75                  80
Gln Val Val Leu Ala Glu Pro Ala Pro Gly Pro Pro Asp Gly Pro His 
                 85                  90                  95
Leu Pro Ile Gln Thr Ala Glu Leu Ala Pro Glu Leu Val Ile Ser Asn 
             100                105                110
Asp Lys Arg Ser Phe Cys His 
         115



<210> 6954
<211> 490
<212> DNA
<213> Rattus norvegicus
<308> AI171462
<400> 6954

gacttttga  atcagattt  ctcaggggt  gctggattt  ggggtgggt  ccaatccat  60
gttgcctgg  ccgtgtcaa  tactaacaa  ggtcaaata  aatatgtca  acctaaagc  120
acagaagga  ggtgtaaaa  gttctgttc  ggagagaag  actagaggt  aacgacgtg  180
gacttcacc  agagtttag  ctattaaat  agtagtaac  aaacaacac  tcggggatt  240
aaaataaca  ctggtagtt  cttccaaca  acacagaaa  agcatcaga  aagcttttg  300
ataccacct  actgcatta  ggccttata  gtcgaagga  ccaatgaaa  taatggacc  360
ccattccac  ccccatcct  ctccctcta  atcaaacct  cgcccgatt  cgagtgaga  420
ttttaagtg  ccacatttc  taagccaca  ttcgagcaa  tcacgtcaa  tttggatgc  480
tgtcttcatc  490



<210> 6955
<211> 76
<212> PRT
<213> Rattus norvegicus
<308> Q07490
<400> 6955

Met Gly Arg Ala Met Val Val Arg Leu Gly Leu Gly Leu Leu Leu Leu 
  1               5                  10                  15
Ala Leu Leu Leu Pro Thr Gln Ile Tyr Cys Asn Gln Thr Ser Val Ala 
             20                  25                  30
Pro Phe Ser Gly Asn Gln Ser Ile Ser Ala Ala Pro Asn Pro Thr Asn 
         35                  40                  45
Ala Thr Thr Arg Ser Gly Cys Ser Ser Leu Gln Ser Thr Ala Gly Leu 
     50                  55                  60
Leu Ala Leu Ser Leu Ser Leu Leu His Leu Tyr Cys 
 65                  70                  75



<210> 6956
<211> 284
<212> DNA
<213> Homo sapiens
<308> AI860750
<400> 6956

ttttttttt  ttttttttt  ttttttttt  ttttttttt  tggcccttt  aaccatttt  60
ttttattta  aggtggggg  caaggcaaa  caattccat  aaaagttac  atgaatcaa  120
gcgtaaata  ccaaaccca  tttacaatc  aaaataaat  tccagcatt  tggaataaa  180
caagagggg  cattccccc  ccccagnng  ttcaaaact  gtcgatctg  ttggtccca  240
ggggttttc  aaaaaagga  aaaaaggac  ttgggcatc  aaac  284



<210> 6957
<211> 490
<212> DNA
<213> Rattus norvegicus
<308> AI171462
<400> 6957

gacttttga  atcagattt  ctcaggggt  gctggattt  ggggtgggt  ccaatccat  60
gttgcctgg  ccgtgtcaa  tactaacaa  ggtcaaata  aatatgtca  acctaaagc  120
acagaagga  ggtgtaaaa  gttctgttc  ggagagaag  actagaggt  aacgacgtg  180
gacttcacc  agagtttag  ctattaaat  agtagtaac  aaacaacac  tcggggatt  240
aaaataaca  ctggtagtt  cttccaaca  acacagaaa  agcatcaga  aagcttttg  300
ataccacct  actgcatta  ggccttata  gtcgaagga  ccaatgaaa  taatggacc  360
ccattccac  ccccatcct  ctccctcta  atcaaacct  cgcccgatt  cgagtgaga  420
ttttaagtg  ccacatttc  taagccaca  ttcgagcaa  tcacgtcaa  tttggatgc  480
tgtcttcatc  490



<210> 6958
<211> 76
<212> PRT
<213> Rattus norvegicus
<308> Q07490
<400> 6958

Met Gly Arg Ala Met Val Val Arg Leu Gly Leu Gly Leu Leu Leu Leu 
  1               5                  10                  15
Ala Leu Leu Leu Pro Thr Gln Ile Tyr Cys Asn Gln Thr Ser Val Ala 
             20                  25                  30
Pro Phe Ser Gly Asn Gln Ser Ile Ser Ala Ala Pro Asn Pro Thr Asn 
         35                  40                  45
Ala Thr Thr Arg Ser Gly Cys Ser Ser Leu Gln Ser Thr Ala Gly Leu 
     50                  55                  60
Leu Ala Leu Ser Leu Ser Leu Leu His Leu Tyr Cys 
 65                  70                  75



<210> 6959
<211> 284
<212> DNA
<213> Homo sapiens
<308> AI860750
<400> 6959

ttttttttt  ttttttttt  ttttttttt  ttttttttt  tggcccttt  aaccatttt  60
ttttattta  aggtggggg  caaggcaaa  caattccat  aaaagttac  atgaatcaa  120
gcgtaaata  ccaaaccca  tttacaatc  aaaataaat  tccagcatt  tggaataaa  180
caagagggg  cattccccc  ccccagnng  ttcaaaact  gtcgatctg  ttggtccca  240
ggggttttc  aaaaaagga  aaaaaggac  ttgggcatc  aaac  284



<210> 6960
<211> 708
<212> DNA
<213> Rattus norvegicus
<308> AI171630
<400> 6960

gaatctgaa  aataggctt  actttaacc  gtggtattg  ctgacatcc  atggcatac  60
agatcacaa  caagttcac  aatacacat  cacagcagt  ttctcattc  cttgtcttc  120
aatggagaa  ctgggtggc  gcagcatcg  accatggat  ccaggagct  ttctgccag  180
tctagcttc  agtccgggc  ctggggcac  gtcctaaca  agcatggcc  catgtgcaa  240
ggcatcctc  atacaataa  cacgcctgg  gttcaaacc  agacgttgc  actaaccat  300
gtgagggga  gacgtggag  tggactgca  actgaggcg  tgaggcctg  ccagtcggc  360
tccttctgg  ctccagatg  tgcagggtc  taccctgcc  cacagaact  catgtccct  420
cactgatag  gaatggaga  accttgacc  aaatacgag  cctgtttcg  ccaacactg  480
aattggctt  acactttct  acatccaac  gaccaatca  attctcgtg  ttcatgtgc  540
tcagcagcc  cagctccct  taggtcctt  tggcgtgaa  gatggactg  aacggtctc  600
acagcttct  cactgccac  cgatgtccc  tctntgtat  aaaagcagc  cacaccgag  660
cgtaggctc  cgagcccac  ggggacagg  tctggtatc  ctcgggca  708



<210> 6961
<211> 360
<212> PRT
<213> Rattus norvegicus
<308> P70618
<400> 6961

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
  1               5                  10                  15
Val Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
             20                  25                  30
Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly His 
         35                  40                  45
Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
     50                  55                  60
Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
 65                  70                  75                  80
Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                 85                  90                  95
Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
             100                105                110
Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
         115                120                125
Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
     130                135                140
Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
 145                150                155                160
Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                 165                170                175
Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
             180                185                190
Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
         195                200                205
Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
     210                215                220
Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
 225                230                235                240
Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                 245                250                255
Asn Tyr Ile Gln Ser Leu Ala Gln Met Pro Lys Met Asn Phe Ala Asn 
             260                265                270
Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
         275                280                285
Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
     290                295                300
His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
 305                310                315                320
Glu Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Phe Leu Ile Asp Glu 
                 325                330                335
Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
             340                345                350
Leu Asp Gln Glu Glu Met Glu Ser 
         355                360



<210> 6962
<211> 3757
<212> DNA
<213> Homo sapiens
<308> L35263
<400> 6962

ggaaccgcg  ccactggag  cttagcggg  gcagcagct  gaacgggag  actgcgacg  60
agcccggag  cggccttgt  ggggcgaag  tgcagggag  tcgcggcgg  cgcagtctt  120
agcgccgga  cgcgtccct  cccttagcg  ggcttgccc  agtcgcagg  gcacatcca  180
ccgctgcgg  tgacagcag  cgcgcgcgc  ggagtctgc  gggtcgcgg  agccgcacc  240
gcgcgggcg  ccagcgcaa  gtccccgcc  ggctgggcg  gcagcaagg  ccggggaga  300
ggtgcgggt  caggcgggg  ccccacagg  ccaccttct  gcccggcgg  tgccgctgg  360
aaatgtctc  ggagaggcc  acgttctac  ggcaggagc  gaacaagac  atctgggag  420
tgcccgagc  ttaccagaa  ctgtctcca  tgggctctg  cgcctatgg  tctgtgtgt  480
ctgcttttg  cacaaaaac  gggttacgt  tggcagtga  gaagctctc  agaccattt  540
agtccatca  tcatgcgaa  agaacctac  gagaactgc  gttacttaa  catatgaaa  600
atgaaaatg  gattggtct  ttggacgtt  ttacacctg  aaggtctct  gaggaattc  660
atgatgtgt  tctggtgac  catctcatg  gggcagatc  gaacaacat  gtgaaatgt  720
agaagctta  agatgacca  gttcagttc  ttatctacc  aattctccg  ggtctaaag  780
atatacatt  agctgacat  attcacagg  acctaaaac  tagtaatct  gctgtgaat  840
aagactgtg  gctgaagat  ctggatttt  gactggctc  gcacacaga  gatgaaatg  900
caggctacg  ggccactag  tggtacagg  ctcctgaga  catgctgaa  tggatgcat  960
acaaccaga  agttgatat  tggtcagtg  gatgcataa  ggccgagct  ttgactgga  1020
gaacattgt  tcctggtac  gaccatatt  accagcttc  gcagattat  cgtctgaca  1080
gaacacccc  cgcttatct  attaacagg  tgccaagcc  tgaggcaag  aactatatt  1140
agtctttga  tcagatgcc  aagatgaac  ttgcgaatg  atttattgg  gccaatccc  1200
tggctgtcg  cttgctgga  aagatgctt  tattggact  agataagag  attacagcg  1260
cccaagccc  tgcacatgc  tactttgct  agtaccacg  tcctgatga  gaaccagtg  1320
ccgatcctt  tgatcagtc  tttgaaagc  gggacctcc  tatagatga  tggaaaagc  1380
tgacctatg  tgaagtcat  agctttgtg  caccacccc  tgaccaaga  gagatggag  1440
cctgagcac  tggtttctg  tctgttgat  ccacttcac  gtgagggga  ggccttttc  1500
cgggaactc  ccaaatatt  ttcaagtgc  tcttgttgc  gagatttcc  ccatggtgg  1560
agggggtgt  cgtgcgtgt  cgtgcgtgt  agtgtgtgt  catgtgtgt  tctgtcttt  1620
tgggagggt  agacaatat  aacaaacta  gatcacagt  actttacag  aggttgtgg  1680
tgctccagg  cagcctcca  cttgctctt  tttctgaga  ttggctcag  cagacaaga  1740
ctgctgtcc  tttaggaat  tgttcaatg  aaagtaaaa  aatatgaat  gtccccaat  1800
ccggtcatg  ttttgccac  ttggcttct  ctgtgaccc  accttgacg  tggggcgta  1860
acttgacaa  atcccacag  ggcacggag  gaaggccca  accttctgg  tgcttcaga  1920
ctgacaccg  ccctcagtg  tacgtacag  caaaaagga  caactggct  ctgtgcact  1980
gcctgtgat  aacttgctt  gtatggttc  cagatcttg  cagtatatt  gaaactgta  2040
atatgtttg  gccttaaaa  gagagaaga  agtgtagat  gttaaaaga  tgcagctgc  2100
gaagttctg  gccgggcaa  tcgagaggg  tgttggaca  ctgcttgtg  gcccggagt  2160
atcaggcag  cttcatagg  ggtcatgtg  gcatgtgag  acatgcgta  atgtgcgtc  2220
ctctttctc  ctcaccccc  ggtgttgcc  tttctctgc  tacccttca  ctttggtgc  2280
gaggtttct  gaatatctg  cccagtagt  agaagcagg  tcttgatgt  atgtacttc  2340
tgtgtactc  ttatttcta  cagagtgag  atgtgtttt  cacgtcttg  tatttgagc  2400
tgcacagct  cttgtcctg  tctcttcag  aggccctgg  gtcaggcag  tttgccagt  2460
aagacttct  gggtagttt  gatcccatg  cacctcagc  gatattatg  caagtgata  2520
cacctctct  cagccccta  tgctattct  tgttgaaca  aattgatac  tcaggtgct  2580
ttgatgtga  aatcatgaa  agaggaaca  gtggatgta  agcattttt  ttcatgcca  2640
ctgttttca  ccaactatt  ttgaggaat  atcatggga  aagaccagg  cttttccca  2700
gaatatccc  aacttcgga  acaagttat  ctcttcact  ccaataact  atgctaaga  2760
atgctgaaa  tcaaagtaa  aaattaaag  ccataaggc  agaaactcc  tttgctgtc  2820
ttctctaaa  atgattact  taaaataaa  aagtaacaa  gtgtctttt  cactcctat  2880
gaaaagggt  ttcttggca  cttaacatt  acttcttgg  ttggggaga  ataaatttt  2940
tttcagaat  ttgtatatt  taggaatcc  tttgagaat  tgattcctt  tgatgggga  3000
aaagggcaa  ttattttaa  attttgtat  ttcaacttt  taaagataa  atatcctca  3060
gggtggaga  gtgtcgttt  cataacttg  tgaatttca  gcattttgt  ctacatgag  3120
actcatata  ttaagcctt  tgtgtaata  gaaagtata  agtcacttc  agtgttggc  3180
gtgtgacag  atcttgtat  tgggccaag  tgtttccat  tctcaatca  tgcagtgat  3240
catgtactc  agagggaca  ggtggaccc  ctgagtcaa  tggagcaag  aggaaggag  3300
cagactgat  gcgattccc  ctcacccgg  actctcccc  tttcaagga  agtgaacct  3360
taaagtaaa  gcctcatct  ctttattgc  gttcaaatc  tcaccatcc  cagcaagat  3420
aattttatc  gccatgttt  gttgtaaat  ctcgtgtga  ttcctacag  aatactgct  3480
tgaatattt  gtaataaag  tctttgcac  tgtgaccac  tacgtgtta  gaggctgca  3540
gctctggaa  cctggactc  aagctggag  tcttggaag  gctcttcgg  ttctgagca  3600
aatgctccc  tctcctgat  tctctgaac  gaaaacaaa  gagagaatg  gggaaattg  3660
tattttatt  gtattcatg  acttggctg  aatcagtta  gccgtatag  atgtcagac  3720
ataccactg  ttaaaataa  gcctatttt  caaattt  3757



<210> 6963
<211> 360
<212> PRT
<213> Homo sapiens
<308> Q16539
<400> 6963

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
  1               5                  10                  15
Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
             20                  25                  30
Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
         35                  40                  45
Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
     50                  55                  60
Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
 65                  70                  75                  80
Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                 85                  90                  95
Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
             100                105                110
Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
         115                120                125
Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
     130                135                140
Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
 145                150                155                160
Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                 165                170                175
Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
             180                185                190
Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
         195                200                205
Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
     210                215                220
Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
 225                230                235                240
Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                 245                250                255
Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
             260                265                270
Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
         275                280                285
Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
     290                295                300
His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
 305                310                315                320
Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                 325                330                335
Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
             340                345                350
Leu Asp Gln Glu Glu Met Glu Ser 
         355                360



<210> 6964
<211> 663
<212> DNA
<213> Rattus norvegicus
<308> AI171966
<400> 6964

gtaattcca  accagttta  ttcttaggt  tgatcgtga  acagtgcct  ctgtgacaa  60
gtggggctt  caggagggc  ctgaacccc  tcctcagag  agctcacct  agaaaacac  120
cgaggcaga  ttgattacg  atacccccc  ggccaccaa  atttacatg  gaaagtgga  180
ctgagtaga  gaattatga  acaagaaag  ggggtgtcc  gaagatgct  gggggcatg  240
aggcaccat  aaaagtctg  atctccttc  cagcgcggg  ctctgccct  tagggccgt  300
cttccgggt  ggtggatcc  gggagagga  tgtagctgg  ggagtgaga  ttgcgccat  360
tgaagaagc  aagacagaa  atgatgaag  ccaggccca  ggtggctgc  gacacagag  420
ccttcactg  ctggatggg  gacagcccg  gtgtccagt  cgcgcggat  ggctcaggg  480
tcccgctgt  ctgtaccac  caggtgtag  tgtcccagt  ggaaggggt  aaggctagg  540
aggagacgg  ctggtatgt  cagtccccg  taggctgag  cgtcttctc  ttgttgctg  600
gggaagtta  aagctgccc  ttcttcatc  acacgacgg  cacatccgc  ggatagaaa  660
ccc  663



<210> 6965
<211> 261
<212> PRT
<213> Rattus norvegicus
<308> CAA89832
<400> 6965

Met Ala Ala Leu Trp Pro Leu Leu Leu Ala Leu Gly Leu Gly Cys Ile 
  1               5                  10                  15
Gly Ala Gly Gly Phe Val Ala His Val Glu Ser Thr Cys Leu Leu Asp 
             20                  25                  30
Asp Glu Gly Thr Pro Met Asp Phe Thr Tyr Cys Ile Ser Phe Asn Lys 
         35                  40                  45
Asp Leu Leu Ala Cys Trp Asp Pro Glu Glu Gly Gln Ile Val Pro Cys 
     50                  55                  60
Glu Tyr Gly Val Leu Phe Lys Leu Ala Glu Phe Ile Ser Asn Ile Leu 
 65                  70                  75                  80
Asn Lys Glu Glu Gly Leu Ile Gln Arg Leu Lys Asn Gly Leu Gln Asp 
                 85                  90                  95
Cys Ser Thr His Thr Gln Pro Phe Trp Asn Ala Leu Thr His Arg Thr 
             100                105                110
Arg Thr Pro Ser Val Gln Val Ala Gln Thr Ala Pro Phe Asn Thr Arg 
         115                120                125
Glu Pro Val Met Leu Ala Cys Tyr Val Trp Gly Phe Tyr Pro Ala Asp 
     130                135                140
Val Thr Val Val Trp Met Lys Asn Gly Gln Leu Val Thr Ser His Ser 
 145                150                155                160
Asn Lys Glu Lys Thr Ala Gln Pro Asn Gly Asp Trp Thr Tyr Gln Thr 
                 165                170                175
Val Ser Tyr Leu Ala Leu Thr Pro Ser Tyr Trp Asp Ile Tyr Thr Cys 
             180                185                190
Val Val Gln His Ser Gly Thr Pro Glu Pro Ile Arg Ala Asn Trp Thr 
         195                200                205
Pro Gly Leu Ser Pro Ile Gln Thr Val Lys Val Ser Val Ser Ala Ala 
     210                215                220
Thr Leu Gly Leu Gly Phe Ile Ile Phe Cys Leu Gly Phe Phe Arg Trp 
 225                230                235                240
Arg Lys Ser His Ser Ser Ser Tyr Thr Pro Leu Pro Gly Ser Thr Tyr 
                 245                250                255
Pro Glu Gly Arg Pro 
             260



<210> 6966
<211> 1362
<212> DNA
<213> Homo sapiens
<308> U15085
<400> 6966

cctgtttgg  acactggac  cccgtgagc  ggaaggaac  gatttaata  ctaggggct  60
ggtatcccc  catcactca  ttggggggt  aagggaccc  ggcaatata  tattctgct  120
agtgtctgg  gatcatcta  ccaggctgg  gcttctggg  caggcgagg  cccacggac  180
ctggaagag  tggtccagg  gactgaact  ccggcatct  tacagagca  agcatgatc  240
cattcctgc  gctgctgct  gggctcagc  tgggctgca  aggagcagg  ggcttcgtg  300
cccatgtgg  aagcacctg  ctgttggat  atgctggga  tccaaagga  ttcacatac  360
gcatctcct  caacaagga  ctgctgacc  gctgggatc  agaggagaa  aagatggcc  420
cttgcgaat  tggggtgct  aatagcttg  cgaatgtcc  ctcacagca  ctcaaccaa  480
aagacaccc  gatgcagcg  ttgcgcaat  ggcttcaga  ttgtgccac  cacacccag  540
ccttctggg  atcactgac  aacaggaca  ggccaccat  tgtgcaagt  gccaaaacc  600
ctcctttta  cacgaggga  cctgtgatg  tggcctgct  tgtgtgggg  ttctatcca  660
cagaagtga  tatcacgtg  aggaagaac  ggaagcttg  catgcctca  agcagtgcg  720
acaagactg  ccagcccaa  ggagactgg  cataccaga  cctctccca  ttagcctta  780
ccccctctt  cggggacac  tacacctgt  tggtagagc  cattggggc  cctgagccc  840
tccttcggg  ctggacacc  gggctgtcc  ccatgcaga  cctgaaggt  tctgtgtct  900
cagtgactc  gggcctggg  ctcatcatc  tctctcttg  tgtgatcag  tggcggaga  960
ctggccact  tagttacac  cctcttcct  ggtccaatt  ttcagaagg  tggcacatt  1020
cctagaggc  gaatcctac  acttccact  caagtgaga  ggagattca  actcaatga  1080
gctaccatg  ctctccaac  tcttcaacc  cctgacatt  tcttggatc  tatggtttc  1140
ccatccaat  ctttgaatt  cccagtctc  cctatgtaa  acttagcaa  ttgggggac  1200
tcattcctg  gactatgct  taaccaaat  attgtccaa  gctatattt  tgggatgaa  1260
ataatctga  gaagggagt  aaagaccct  ctggggctc  cagtgtgcc  tagaggaca  1320
caactggtg  ttgtttcag  gaaataaac  ttggtggaa  aa  1362



<210> 6967
<211> 263
<212> PRT
<213> Homo sapiens
<308> P28068
<400> 6967

Met Ile Thr Phe Leu Pro Leu Leu Leu Gly Leu Ser Leu Gly Cys Thr 
  1               5                  10                  15
Gly Ala Gly Gly Phe Val Ala His Val Glu Ser Thr Cys Leu Leu Asp 
             20                  25                  30
Asp Ala Gly Thr Pro Lys Asp Phe Thr Tyr Cys Ile Ser Phe Asn Lys 
         35                  40                  45
Asp Leu Leu Thr Cys Trp Asp Pro Glu Glu Asn Lys Met Ala Pro Cys 
     50                  55                  60
Glu Phe Gly Val Leu Asn Ser Leu Ala Asn Val Leu Ser Gln His Leu 
 65                  70                  75                  80
Asn Gln Lys Asp Thr Leu Met Gln Arg Leu Arg Asn Gly Leu Gln Asn 
                 85                  90                  95
Cys Ala Thr His Thr Gln Pro Phe Trp Gly Ser Leu Thr Asn Arg Thr 
             100                105                110
Arg Pro Pro Ser Val Gln Val Ala Lys Thr Thr Pro Phe Asn Thr Arg 
         115                120                125
Glu Pro Val Met Leu Ala Cys Tyr Val Trp Gly Phe Tyr Pro Ala Glu 
     130                135                140
Val Thr Ile Thr Trp Arg Lys Asn Gly Lys Leu Val Met Pro His Ser 
 145                150                155                160
Ser Ala His Lys Thr Ala Gln Pro Asn Gly Asp Trp Thr Tyr Gln Thr 
                 165                170                175
Leu Ser His Leu Ala Leu Thr Pro Ser Tyr Gly Asp Thr Tyr Thr Cys 
             180                185                190
Val Val Glu His Ile Gly Ala Pro Glu Pro Ile Leu Arg Asp Trp Thr 
         195                200                205
Pro Gly Leu Ser Pro Met Gln Thr Leu Lys Val Ser Val Ser Ala Val 
     210                215                220
Thr Leu Gly Leu Gly Leu Ile Ile Phe Ser Leu Gly Val Ile Ser Trp 
 225                230                235                240
Arg Arg Ala Gly His Ser Ser Tyr Thr Pro Leu Pro Gly Ser Asn Tyr 
                 245                250                255
Ser Glu Gly Trp His Ile Ser 
             260



<210> 6968
<211> 550
<212> DNA
<213> Rattus norvegicus
<308> AI172017
<400> 6968

agggctcag  gaactgacc  cgaggcttt  tctgctgat  tttattgct  atttgttta  60
gcactgagg  tggaaccca  catccagca  agaaggacc  agtgagcgt  tgtgcgtgc  120
cgtggtagt  tgcacagag  tcctccctt  cccagttta  tggggacgc  ccccacaca  180
cggccacca  ccctgccct  tttatcaaa  cctgacttt  ttggcccaa  acgctttgg  240
gaaggggtt  tctcttggc  ggcgcagtg  gcttggtgg  ggcttttct  aggatcttg  300
tgggttttt  ggcgctggc  gaggaagcc  gcacgccac  ttacgagtt  ttctgtggc  360
ctttgacgg  gaccgtctt  acttccgtg  aggcctgca  gccatactc  cccagctcc  420
tgccgctcc  cgacatctt  tagccacca  atggggact  ggccccaaa  acatcgtag  480
agttgatcc  cacagtccc  gcctgcaga  cttgggaca  gtaattggc  ttgtccagg  540
cctttgtgaa  550



<210> 6969
<211> 519
<212> PRT
<213> Rattus norvegicus
<308> P11884
<400> 6969

Met Leu Arg Ala Ala Leu Ser Thr Ala Arg Arg Gly Pro Arg Leu Ser 
  1               5                  10                  15
Arg Leu Leu Ser Ala Ala Ala Thr Ser Ala Val Pro Ala Pro Asn Gln 
             20                  25                  30
Gln Pro Glu Val Phe Cys Asn Gln Ile Phe Ile Asn Asn Glu Trp His 
         35                  40                  45
Asp Ala Val Ser Lys Lys Thr Phe Pro Thr Val Asn Pro Ser Thr Gly 
     50                  55                  60
Glu Val Ile Cys Gln Val Ala Glu Gly Asn Lys Glu Asp Val Asp Lys 
 65                  70                  75                  80
Ala Val Lys Ala Ala Gln Ala Ala Phe Gln Leu Gly Ser Pro Trp Arg 
                 85                  90                  95
Arg Met Asp Ala Ser Asp Arg Gly Arg Leu Leu Tyr Arg Leu Ala Asp 
             100                105                110
Leu Ile Glu Arg Asp Arg Thr Tyr Leu Ala Ala Leu Glu Thr Leu Asp 
         115                120                125
Asn Gly Lys Pro Tyr Val Ile Ser Tyr Leu Val Asp Leu Asp Met Val 
     130                135                140
Leu Lys Cys Leu Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Tyr His Gly 
 145                150                155                160
Lys Thr Ile Pro Ile Asp Gly Asp Phe Phe Ser Tyr Thr Arg His Glu 
                 165                170                175
Pro Val Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu 
             180                185                190
Met Gln Ala Trp Lys Leu Gly Pro Ala Leu Ala Thr Gly Asn Val Val 
         195                200                205
Val Met Lys Val Ala Glu Gln Thr Pro Leu Thr Ala Leu Tyr Val Ala 
     210                215                220
Asn Leu Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val 
 225                230                235                240
Pro Gly Phe Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Glu Asp 
                 245                250                255
Val Asp Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly His Leu Ile 
             260                265                270
Gln Val Ala Ala Gly Ser Ser Asn Leu Lys Arg Val Thr Leu Glu Leu 
         275                280                285
Gly Gly Lys Ser Pro Asn Ile Ile Met Ser Asp Ala Asp Met Asp Trp 
     290                295                300
Ala Val Glu Gln Ala His Phe Ala Leu Phe Phe Asn Gln Gly Gln Cys 
 305                310                315                320
Cys Cys Ala Gly Ser Arg Thr Phe Val Gln Glu Asp Val Tyr Asp Glu 
                 325                330                335
Phe Val Glu Arg Ser Val Ala Arg Ala Lys Ser Arg Val Val Gly Asn 
             340                345                350
Pro Phe Asp Ser Arg Thr Glu Gln Gly Pro Gln Val Asp Glu Thr Gln 
         355                360                365
Phe Lys Lys Ile Leu Gly Tyr Ile Lys Ser Gly Gln Gln Glu Gly Ala 
     370                375                380
Lys Leu Leu Cys Gly Gly Gly Ala Ala Ala Asp Arg Gly Tyr Phe Ile 
 385                390                395                400
Gln Pro Thr Val Phe Gly Asp Val Lys Asp Gly Met Thr Ile Ala Lys 
                 405                410                415
Glu Glu Ile Phe Gly Pro Val Met Gln Ile Leu Lys Phe Lys Thr Ile 
             420                425                430
Glu Glu Val Val Gly Arg Ala Asn Asn Ser Lys Tyr Gly Leu Ala Ala 
         435                440                445
Ala Val Phe Thr Lys Asp Leu Asp Lys Ala Asn Tyr Leu Ser Gln Ala 
     450                455                460
Leu Gln Ala Gly Thr Val Trp Ile Asn Cys Tyr Asp Val Phe Gly Ala 
 465                470                475                480
Gln Ser Pro Phe Gly Gly Tyr Lys Met Ser Gly Ser Gly Arg Glu Leu 
                 485                490                495
Gly Glu Tyr Gly Leu Gln Ala Tyr Thr Glu Val Lys Thr Val Thr Val 
             500                505                510
Lys Val Pro Gln Lys Asn Ser 
         515



<210> 6970
<211> 1603
<212> DNA
<213> Homo sapiens
<308> K03001
<400> 6970

ctggcggcc  tggagaccc  ggacaatgg  aagccctat  tcatctcct  cctggtgga  60
ttggacatg  tcctcaaat  tctccggta  tatgccggc  gggctgata  gtaccacgg  120
aaaaccatc  ccattgacg  agacttctt  agctacaca  gccatgaac  tgtgggggt  180
tgcgggcag  tcattccgt  gaatttccc  ctcctgatg  aagcatgga  gctgggccc  240
gccttggca  ctggaaacg  ggttgtgat  aaggtagct  agcagacac  cctcaccgc  300
ctctatgtg  ccaacctga  caaggaggc  ggctttccc  ctggtgtgg  caacattgt  360
cctggattt  gccccacgg  tggggccgc  attgcctcc  atgaggatg  ggacaaagt  420
gcattcaca  gctccactg  gattggccg  gtaatccag  ttgctgctg  gagcagcaa  480
ctcaagaga  tgaccttgg  gctgggggg  aagagcccc  acatcatca  gtcagatgc  540
gatatggat  gggccgtgg  acaggccca  ttcgccctg  tcttcaacc  gggccagtg  600
tgctgtgcc  gctcccgga  cttcgtgca  gaggacatc  atgatgagt  tgtggtgcg  660
agcgttgcc  gggccaagt  tcgggtggt  gggaacccc  ttgatagca  gaccgagca  720
gggccgcag  tggatgaaa  tcagtttaa  aagatcctc  gctacatca  cacggggaa  780
caagagggg  cgaagctgc  gtgtggtgg  ggcattgct  ctgaccgtg  ttacttcat  840
cagcccact  tgtttggag  tgtgcagga  ggcatgacc  tcgccaagg  ggagatctt  900
gggccagtg  tgcagatcc  gaagttcaa  accatagag  aggttgttg  gagagccaa  960
aattccacg  acgggctgg  cgcagctgt  ttcacaaag  atttggaca  ggccaatta  1020
ctgtcccag  ccctccagg  gggcactgt  tgggtcaac  gctatgatg  gtttggagc  1080
cagtcaccc  ttggtggct  caagatgtc  gggagtggc  gggagttgg  cgagtacgg  1140
ctgcaggca  acactgaag  gaaaactgt  acagtcaaa  tgcctcaga  gaactcata  1200
gaatcatgc  agcttcctc  ctcagccat  gatggaaag  tcagcaaga  cagcaacaa  1260
accaagaaa  atgatcctt  cgtgctgaa  atctgaaaa  agaaatttt  cctacaaaa  1320
ctcttgggt  aagaaagtt  tagaatttg  attgataaa  atggtgggt  ggctgaggg  1380
aagagtata  gaggaacct  ttaaacgac  acaatactg  tagctttca  gatgatttt  1440
aaaaaatag  ttcaaatgt  ttatcctct  tctgaaacg  ttcctataa  tcgagttta  1500
aggggaaga  aaagctatt  tttacaatt  tatcaccat  aaggcaact  ctacaccct  1560
ctttgtatt  tgggctaag  ttcattaaa  actagctgc  ctt  1603



<210> 6971
<211> 517
<212> PRT
<213> Homo sapiens
<308> P05091
<400> 6971

Met Leu Arg Ala Ala Ala Arg Phe Gly Pro Arg Leu Gly Arg Arg Leu 
  1               5                  10                  15
Leu Ser Ala Ala Ala Thr Gln Ala Val Pro Ala Pro Asn Gln Gln Pro 
             20                  25                  30
Glu Val Phe Cys Asn Gln Ile Phe Ile Asn Asn Glu Trp His Asp Ala 
         35                  40                  45
Val Ser Arg Lys Thr Phe Pro Thr Val Asn Pro Ser Thr Gly Glu Val 
     50                  55                  60
Ile Cys Gln Val Ala Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 
 65                  70                  75                  80
Lys Ala Ala Arg Ala Ala Phe Gln Leu Gly Ser Pro Trp Arg Arg Met 
                 85                  90                  95
Asp Ala Ser His Arg Gly Arg Leu Leu Asn Arg Leu Ala Asp Leu Ile 
             100                105                110
Glu Arg Asp Arg Thr Tyr Leu Ala Ala Leu Glu Thr Leu Asp Asn Gly 
         115                120                125
Lys Pro Tyr Val Ile Ser Tyr Leu Val Asp Leu Asp Met Val Leu Lys 
     130                135                140
Cys Leu Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Tyr His Gly Lys Thr 
 145                150                155                160
Ile Pro Ile Asp Gly Asp Phe Phe Ser Tyr Thr Arg His Glu Pro Val 
                 165                170                175
Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Gln 
             180                185                190
Ala Trp Lys Leu Gly Pro Ala Leu Ala Thr Gly Asn Val Val Val Met 
         195                200                205
Lys Val Ala Glu Gln Thr Pro Leu Thr Ala Leu Tyr Val Ala Asn Leu 
     210                215                220
Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
 225                230                235                240
Phe Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Glu Asp Val Asp 
                 245                250                255
Lys Val Ala Phe Thr Gly Ser Thr Glu Ile Gly Arg Val Ile Gln Val 
             260                265                270
Ala Ala Gly Ser Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
         275                280                285
Lys Ser Pro Asn Ile Ile Met Ser Asp Ala Asp Met Asp Trp Ala Val 
     290                295                300
Glu Gln Ala His Phe Ala Leu Phe Phe Asn Gln Gly Gln Cys Cys Cys 
 305                310                315                320
Ala Gly Ser Arg Thr Phe Val Gln Glu Asp Ile Tyr Asp Glu Phe Val 
                 325                330                335
Glu Arg Ser Val Ala Arg Ala Lys Ser Arg Val Val Gly Asn Pro Phe 
             340                345                350
Asp Ser Lys Thr Glu Gln Gly Pro Gln Val Asp Glu Thr Gln Phe Lys 
         355                360                365
Lys Ile Leu Gly Tyr Ile Asn Thr Gly Lys Gln Glu Gly Ala Lys Leu 
     370                375                380
Leu Cys Gly Gly Gly Ile Ala Ala Asp Arg Gly Tyr Phe Ile Gln Pro 
 385                390                395                400
Thr Val Phe Gly Asp Val Gln Asp Gly Met Thr Ile Ala Lys Glu Glu 
                 405                410                415
Ile Phe Gly Pro Val Met Gln Ile Leu Lys Phe Lys Thr Ile Glu Glu 
             420                425                430
Val Val Gly Arg Ala Asn Asn Ser Thr Tyr Gly Leu Ala Ala Ala Val 
         435                440                445
Phe Thr Lys Asp Leu Asp Lys Ala Asn Tyr Leu Ser Gln Ala Leu Gln 
     450                455                460
Ala Gly Thr Val Trp Val Asn Cys Tyr Asp Val Phe Gly Ala Gln Ser 
 465                470                475                480
Pro Phe Gly Gly Tyr Lys Met Ser Gly Ser Gly Arg Glu Leu Gly Glu 
                 485                490                495
Tyr Gly Leu Gln Ala Tyr Thr Glu Val Lys Thr Val Thr Val Lys Val 
             500                505                510
Pro Gln Lys Asn Ser 
         515



<210> 6972
<211> 550
<212> DNA
<213> Rattus norvegicus
<308> AI172017
<400> 6972

agggctcag  gaactgacc  cgaggcttt  tctgctgat  tttattgct  atttgttta  60
gcactgagg  tggaaccca  catccagca  agaaggacc  agtgagcgt  tgtgcgtgc  120
cgtggtagt  tgcacagag  tcctccctt  cccagttta  tggggacgc  ccccacaca  180
cggccacca  ccctgccct  tttatcaaa  cctgacttt  ttggcccaa  acgctttgg  240
gaaggggtt  tctcttggc  ggcgcagtg  gcttggtgg  ggcttttct  aggatcttg  300
tgggttttt  ggcgctggc  gaggaagcc  gcacgccac  ttacgagtt  ttctgtggc  360
ctttgacgg  gaccgtctt  acttccgtg  aggcctgca  gccatactc  cccagctcc  420
tgccgctcc  cgacatctt  tagccacca  atggggact  ggccccaaa  acatcgtag  480
agttgatcc  cacagtccc  gcctgcaga  cttgggaca  gtaattggc  ttgtccagg  540
cctttgtgaa  550



<210> 6973
<211> 519
<212> PRT
<213> Rattus norvegicus
<308> P11884
<400> 6973

Met Leu Arg Ala Ala Leu Ser Thr Ala Arg Arg Gly Pro Arg Leu Ser 
  1               5                  10                  15
Arg Leu Leu Ser Ala Ala Ala Thr Ser Ala Val Pro Ala Pro Asn Gln 
             20                  25                  30
Gln Pro Glu Val Phe Cys Asn Gln Ile Phe Ile Asn Asn Glu Trp His 
         35                  40                  45
Asp Ala Val Ser Lys Lys Thr Phe Pro Thr Val Asn Pro Ser Thr Gly 
     50                  55                  60
Glu Val Ile Cys Gln Val Ala Glu Gly Asn Lys Glu Asp Val Asp Lys 
 65                  70                  75                  80
Ala Val Lys Ala Ala Gln Ala Ala Phe Gln Leu Gly Ser Pro Trp Arg 
                 85                  90                  95
Arg Met Asp Ala Ser Asp Arg Gly Arg Leu Leu Tyr Arg Leu Ala Asp 
             100                105                110
Leu Ile Glu Arg Asp Arg Thr Tyr Leu Ala Ala Leu Glu Thr Leu Asp 
         115                120                125
Asn Gly Lys Pro Tyr Val Ile Ser Tyr Leu Val Asp Leu Asp Met Val 
     130                135                140
Leu Lys Cys Leu Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Tyr His Gly 
 145                150                155                160
Lys Thr Ile Pro Ile Asp Gly Asp Phe Phe Ser Tyr Thr Arg His Glu 
                 165                170                175
Pro Val Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu 
             180                185                190
Met Gln Ala Trp Lys Leu Gly Pro Ala Leu Ala Thr Gly Asn Val Val 
         195                200                205
Val Met Lys Val Ala Glu Gln Thr Pro Leu Thr Ala Leu Tyr Val Ala 
     210                215                220
Asn Leu Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val 
 225                230                235                240
Pro Gly Phe Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Glu Asp 
                 245                250                255
Val Asp Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly His Leu Ile 
             260                265                270
Gln Val Ala Ala Gly Ser Ser Asn Leu Lys Arg Val Thr Leu Glu Leu 
         275                280                285
Gly Gly Lys Ser Pro Asn Ile Ile Met Ser Asp Ala Asp Met Asp Trp 
     290                295                300
Ala Val Glu Gln Ala His Phe Ala Leu Phe Phe Asn Gln Gly Gln Cys 
 305                310                315                320
Cys Cys Ala Gly Ser Arg Thr Phe Val Gln Glu Asp Val Tyr Asp Glu 
                 325                330                335
Phe Val Glu Arg Ser Val Ala Arg Ala Lys Ser Arg Val Val Gly Asn 
             340                345                350
Pro Phe Asp Ser Arg Thr Glu Gln Gly Pro Gln Val Asp Glu Thr Gln 
         355                360                365
Phe Lys Lys Ile Leu Gly Tyr Ile Lys Ser Gly Gln Gln Glu Gly Ala 
     370                375                380
Lys Leu Leu Cys Gly Gly Gly Ala Ala Ala Asp Arg Gly Tyr Phe Ile 
 385                390                395                400
Gln Pro Thr Val Phe Gly Asp Val Lys Asp Gly Met Thr Ile Ala Lys 
                 405                410                415
Glu Glu Ile Phe Gly Pro Val Met Gln Ile Leu Lys Phe Lys Thr Ile 
             420                425                430
Glu Glu Val Val Gly Arg Ala Asn Asn Ser Lys Tyr Gly Leu Ala Ala 
         435                440                445
Ala Val Phe Thr Lys Asp Leu Asp Lys Ala Asn Tyr Leu Ser Gln Ala 
     450                455                460
Leu Gln Ala Gly Thr Val Trp Ile Asn Cys Tyr Asp Val Phe Gly Ala 
 465                470                475                480
Gln Ser Pro Phe Gly Gly Tyr Lys Met Ser Gly Ser Gly Arg Glu Leu 
                 485                490                495
Gly Glu Tyr Gly Leu Gln Ala Tyr Thr Glu Val Lys Thr Val Thr Val 
             500                505                510
Lys Val Pro Gln Lys Asn Ser 
         515



<210> 6974
<211> 1603
<212> DNA
<213> Homo sapiens
<308> K03001
<400> 6974

ctggcggcc  tggagaccc  ggacaatgg  aagccctat  tcatctcct  cctggtgga  60
ttggacatg  tcctcaaat  tctccggta  tatgccggc  gggctgata  gtaccacgg  120
aaaaccatc  ccattgacg  agacttctt  agctacaca  gccatgaac  tgtgggggt  180
tgcgggcag  tcattccgt  gaatttccc  ctcctgatg  aagcatgga  gctgggccc  240
gccttggca  ctggaaacg  ggttgtgat  aaggtagct  agcagacac  cctcaccgc  300
ctctatgtg  ccaacctga  caaggaggc  ggctttccc  ctggtgtgg  caacattgt  360
cctggattt  gccccacgg  tggggccgc  attgcctcc  atgaggatg  ggacaaagt  420
gcattcaca  gctccactg  gattggccg  gtaatccag  ttgctgctg  gagcagcaa  480
ctcaagaga  tgaccttgg  gctgggggg  aagagcccc  acatcatca  gtcagatgc  540
gatatggat  gggccgtgg  acaggccca  ttcgccctg  tcttcaacc  gggccagtg  600
tgctgtgcc  gctcccgga  cttcgtgca  gaggacatc  atgatgagt  tgtggtgcg  660
agcgttgcc  gggccaagt  tcgggtggt  gggaacccc  ttgatagca  gaccgagca  720
gggccgcag  tggatgaaa  tcagtttaa  aagatcctc  gctacatca  cacggggaa  780
caagagggg  cgaagctgc  gtgtggtgg  ggcattgct  ctgaccgtg  ttacttcat  840
cagcccact  tgtttggag  tgtgcagga  ggcatgacc  tcgccaagg  ggagatctt  900
gggccagtg  tgcagatcc  gaagttcaa  accatagag  aggttgttg  gagagccaa  960
aattccacg  acgggctgg  cgcagctgt  ttcacaaag  atttggaca  ggccaatta  1020
ctgtcccag  ccctccagg  gggcactgt  tgggtcaac  gctatgatg  gtttggagc  1080
cagtcaccc  ttggtggct  caagatgtc  gggagtggc  gggagttgg  cgagtacgg  1140
ctgcaggca  acactgaag  gaaaactgt  acagtcaaa  tgcctcaga  gaactcata  1200
gaatcatgc  agcttcctc  ctcagccat  gatggaaag  tcagcaaga  cagcaacaa  1260
accaagaaa  atgatcctt  cgtgctgaa  atctgaaaa  agaaatttt  cctacaaaa  1320
ctcttgggt  aagaaagtt  tagaatttg  attgataaa  atggtgggt  ggctgaggg  1380
aagagtata  gaggaacct  ttaaacgac  acaatactg  tagctttca  gatgatttt  1440
aaaaaatag  ttcaaatgt  ttatcctct  tctgaaacg  ttcctataa  tcgagttta  1500
aggggaaga  aaagctatt  tttacaatt  tatcaccat  aaggcaact  ctacaccct  1560
ctttgtatt  tgggctaag  ttcattaaa  actagctgc  ctt  1603



<210> 6975
<211> 517
<212> PRT
<213> Homo sapiens
<308> P05091
<400> 6975

Met Leu Arg Ala Ala Ala Arg Phe Gly Pro Arg Leu Gly Arg Arg Leu 
  1               5                  10                  15
Leu Ser Ala Ala Ala Thr Gln Ala Val Pro Ala Pro Asn Gln Gln Pro 
             20                  25                  30
Glu Val Phe Cys Asn Gln Ile Phe Ile Asn Asn Glu Trp His Asp Ala 
         35                  40                  45
Val Ser Arg Lys Thr Phe Pro Thr Val Asn Pro Ser Thr Gly Glu Val 
     50                  55                  60
Ile Cys Gln Val Ala Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 
 65                  70                  75                  80
Lys Ala Ala Arg Ala Ala Phe Gln Leu Gly Ser Pro Trp Arg Arg Met 
                 85                  90                  95
Asp Ala Ser His Arg Gly Arg Leu Leu Asn Arg Leu Ala Asp Leu Ile 
             100                105                110
Glu Arg Asp Arg Thr Tyr Leu Ala Ala Leu Glu Thr Leu Asp Asn Gly 
         115                120                125
Lys Pro Tyr Val Ile Ser Tyr Leu Val Asp Leu Asp Met Val Leu Lys 
     130                135                140
Cys Leu Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Tyr His Gly Lys Thr 
 145                150                155                160
Ile Pro Ile Asp Gly Asp Phe Phe Ser Tyr Thr Arg His Glu Pro Val 
                 165                170                175
Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Gln 
             180                185                190
Ala Trp Lys Leu Gly Pro Ala Leu Ala Thr Gly Asn Val Val Val Met 
         195                200                205
Lys Val Ala Glu Gln Thr Pro Leu Thr Ala Leu Tyr Val Ala Asn Leu 
     210                215                220
Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
 225                230                235                240
Phe Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Glu Asp Val Asp 
                 245                250                255
Lys Val Ala Phe Thr Gly Ser Thr Glu Ile Gly Arg Val Ile Gln Val 
             260                265                270
Ala Ala Gly Ser Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
         275                280                285
Lys Ser Pro Asn Ile Ile Met Ser Asp Ala Asp Met Asp Trp Ala Val 
     290                295                300
Glu Gln Ala His Phe Ala Leu Phe Phe Asn Gln Gly Gln Cys Cys Cys 
 305                310                315                320
Ala Gly Ser Arg Thr Phe Val Gln Glu Asp Ile Tyr Asp Glu Phe Val 
                 325                330                335
Glu Arg Ser Val Ala Arg Ala Lys Ser Arg Val Val Gly Asn Pro Phe 
             340                345                350
Asp Ser Lys Thr Glu Gln Gly Pro Gln Val Asp Glu Thr Gln Phe Lys 
         355                360                365
Lys Ile Leu Gly Tyr Ile Asn Thr Gly Lys Gln Glu Gly Ala Lys Leu 
     370                375                380
Leu Cys Gly Gly Gly Ile Ala Ala Asp Arg Gly Tyr Phe Ile Gln Pro 
 385                390                395                400
Thr Val Phe Gly Asp Val Gln Asp Gly Met Thr Ile Ala Lys Glu Glu 
                 405                410                415
Ile Phe Gly Pro Val Met Gln Ile Leu Lys Phe Lys Thr Ile Glu Glu 
             420                425                430
Val Val Gly Arg Ala Asn Asn Ser Thr Tyr Gly Leu Ala Ala Ala Val 
         435                440                445
Phe Thr Lys Asp Leu Asp Lys Ala Asn Tyr Leu Ser Gln Ala Leu Gln 
     450                455                460
Ala Gly Thr Val Trp Val Asn Cys Tyr Asp Val Phe Gly Ala Gln Ser 
 465                470                475                480
Pro Phe Gly Gly Tyr Lys Met Ser Gly Ser Gly Arg Glu Leu Gly Glu 
                 485                490                495
Tyr Gly Leu Gln Ala Tyr Thr Glu Val Lys Thr Val Thr Val Lys Val 
             500                505                510
Pro Gln Lys Asn Ser 
         515



<210> 6976
<211> 471
<212> DNA
<213> Rattus norvegicus
<308> AI172247
<400> 6976

gccttccat  atgcaaacg  aggtggagg  ttttatgtc  ctctgctgt  tcgctgaaa  60
ctatgagtg  gactctggg  ttaaagcat  gcactttga  tgacttgag  gatgtaagc  120
ttctgaata  ggcatgcag  tctagagga  ctttggttt  agattcagg  ggtgtgtga  180
gattctggt  acatacacc  ttgagtgag  agggacata  cacaaatgc  tcctaaact  240
atttcaaac  cgtggtcaa  gtggactcg  aatcatcca  gctgctgat  cgcccctta  300
gccaacagc  ccccatttg  ttattggtt  gtttgcagc  cttatttgg  tcaaaattg  360
ccatcttct  gaaaatgtc  tcctgctga  tcccacgcg  catgcggaa  tctggatac  420
acaggatgt  cttgtggct  caaggaatc  ttgctgcgg  acaaaccac  g  471



<210> 6977
<211> 1330
<212> PRT
<213> Rattus norvegicus
<308> P22985
<400> 6977

Thr Ala Asp Glu Leu Val Phe Phe Val Asn Gly Lys Lys Val Val Glu 
  1               5                  10                  15
Lys Asn Ala Asp Pro Glu Thr Thr Leu Leu Val Tyr Leu Arg Arg Lys 
             20                  25                  30
Leu Gly Leu Cys Gly Thr Lys Leu Gly Cys Gly Glu Gly Gly Cys Gly 
         35                  40                  45
Ala Cys Thr Val Met Ile Ser Lys Tyr Asp Arg Leu Gln Asn Lys Ile 
     50                  55                  60
Val His Phe Ser Val Asn Ala Cys Leu Ala Pro Ile Cys Ser Leu His 
 65                  70                  75                  80
His Val Ala Val Thr Thr Val Glu Gly Ile Gly Asn Thr Gln Lys Leu 
                 85                  90                  95
His Pro Val Gln Glu Arg Ile Ala Arg Ser His Gly Ser Gln Cys Gly 
             100                105                110
Phe Cys Thr Pro Gly Ile Val Met Ser Met Tyr Thr Leu Leu Arg Asn 
         115                120                125
Gln Pro Glu Pro Thr Val Glu Glu Ile Glu Asn Ala Phe Gln Gly Asn 
     130                135                140
Leu Cys Arg Cys Thr Gly Tyr Arg Pro Ile Leu Gln Gly Phe Arg Thr 
 145                150                155                160
Phe Ala Lys Asp Gly Gly Cys Cys Gly Gly Ser Gly Asn Asn Pro Asn 
                 165                170                175
Cys Cys Met Asn Gln Thr Lys Asp Gln Thr Val Ser Leu Ser Pro Ser 
             180                185                190
Leu Phe Asn Pro Glu Asp Phe Lys Pro Leu Asp Pro Thr Gln Glu Pro 
         195                200                205
Ile Phe Pro Pro Glu Leu Leu Arg Leu Lys Asp Thr Pro Gln Lys Lys 
     210                215                220
Leu Arg Phe Glu Gly Glu Arg Val Thr Trp Ile Gln Ala Ser Thr Met 
 225                230                235                240
Glu Glu Leu Leu Asp Leu Lys Ala Gln His Pro Asp Ala Lys Leu Val 
                 245                250                255
Val Gly Asn Thr Glu Ile Gly Ile Glu Met Lys Phe Lys Asn Met Leu 
             260                265                270
Phe Pro Leu Ile Val Cys Pro Ala Trp Ile Pro Glu Leu Asn Ser Val 
         275                280                285
Val His Gly Pro Glu Gly Ile Ser Phe Gly Ala Ser Cys Pro Leu Ser 
     290                295                300
Leu Val Glu Ser Val Leu Ala Glu Glu Ile Ala Lys Leu Pro Glu Gln 
 305                310                315                320
Lys Thr Glu Val Phe Arg Gly Val Met Glu Gln Leu Arg Trp Phe Ala 
                 325                330                335
Gly Lys Gln Val Lys Ser Val Ala Ser Ile Gly Gly Asn Ile Ile Thr 
             340                345                350
Ala Ser Pro Ile Ser Asp Leu Asn Pro Val Phe Met Ala Ser Gly Ala 
         355                360                365
Lys Leu Thr Leu Val Ser Arg Gly Thr Arg Arg Thr Val Arg Met Asp 
     370                375                380
His Thr Phe Phe Pro Gly Tyr Arg Lys Thr Leu Leu Arg Pro Glu Glu 
 385                390                395                400
Ile Leu Leu Ser Ile Glu Ile Pro Tyr Ser Lys Glu Gly Glu Phe Phe 
                 405                410                415
Ser Ala Phe Lys Gln Ala Ser Arg Arg Glu Asp Asp Ile Ala Lys Val 
             420                425                430
Thr Ser Gly Met Arg Val Leu Phe Lys Pro Gly Thr Ile Glu Val Gln 
         435                440                445
Glu Leu Ser Leu Cys Phe Gly Gly Met Ala Asp Arg Thr Ile Ser Ala 
     450                455                460
Leu Lys Thr Thr Pro Lys Gln Leu Ser Lys Ser Trp Asn Glu Glu Leu 
 465                470                475                480
Leu Gln Ser Val Cys Ala Gly Leu Ala Glu Glu Leu Gln Leu Ala Pro 
                 485                490                495
Asp Ala Pro Gly Gly Met Val Glu Phe Arg Arg Thr Leu Thr Leu Ser 
             500                505                510
Phe Phe Phe Lys Phe Tyr Leu Thr Val Leu Gln Lys Leu Gly Arg Ala 
         515                520                525
Asp Leu Glu Asp Met Cys Gly Lys Leu Asp Pro Thr Phe Ala Ser Ala 
     530                535                540
Thr Leu Leu Phe Gln Lys Asp Pro Pro Ala Asn Val Gln Leu Phe Gln 
 545                550                555                560
Glu Val Pro Lys Asp Gln Ser Glu Glu Asp Met Val Gly Arg Pro Leu 
                 565                570                575
Pro His Leu Ala Ala Asn Met Gln Ala Ser Gly Glu Ala Val Tyr Cys 
             580                585                590
Asp Asp Ile Pro Arg Tyr Glu Asn Glu Leu Ser Leu Arg Leu Val Thr 
         595                600                605
Ser Thr Arg Ala His Ala Lys Ile Thr Ser Ile Asp Thr Ser Glu Ala 
     610                615                620
Lys Lys Val Pro Gly Phe Val Cys Phe Leu Thr Ala Glu Asp Val Pro 
 625                630                635                640
Asn Ser Asn Ala Thr Gly Leu Phe Asn Asp Glu Thr Val Phe Ala Lys 
                 645                650                655
Asp Glu Val Thr Cys Val Gly His Ile Ile Gly Ala Val Val Ala Asp 
             660                665                670
Thr Pro Glu His Ala Gln Arg Ala Ala Arg Gly Val Lys Ile Thr Tyr 
         675                680                685
Glu Asp Leu Pro Ala Ile Ile Thr Ile Gln Asp Ala Ile Asn Asn Asn 
     690                695                700
Ser Phe Tyr Gly Ser Glu Ile Lys Ile Glu Lys Gly Asp Leu Lys Lys 
 705                710                715                720
Gly Phe Ser Glu Ala Asp Asn Val Val Ser Gly Glu Leu Tyr Ile Gly 
                 725                730                735
Gly Gln Glu His Phe Tyr Leu Glu Thr Asn Cys Thr Ile Ala Val Pro 
             740                745                750
Lys Gly Glu Ala Gly Glu Met Glu Leu Phe Val Ser Thr Gln Asn Thr 
         755                760                765
Met Lys Thr Gln Ser Phe Val Ala Lys Met Leu Gly Val Pro Asp Asn 
     770                775                780
Arg Ile Val Val Arg Val Lys Arg Met Gly Gly Gly Phe Gly Gly Lys 
 785                790                795                800
Glu Thr Arg Ser Thr Val Val Ser Thr Ala Leu Ala Leu Ala Ala His 
                 805                810                815
Lys Thr Gly Arg Pro Val Arg Cys Met Leu Asp Arg Asp Glu Asp Met 
             820                825                830
Leu Ile Thr Gly Gly Arg His Pro Phe Leu Ala Lys Tyr Lys Val Gly 
         835                840                845
Phe Met Lys Thr Gly Thr Val Val Ala Leu Glu Val Ala His Phe Ser 
     850                855                860
Asn Gly Gly Asn Thr Glu Asp Leu Ser Arg Ser Ile Met Glu Arg Ala 
 865                870                875                880
Leu Phe His Met Asp Asn Ala Tyr Lys Ile Pro Asn Ile Arg Gly Thr 
                 885                890                895
Gly Arg Ile Cys Lys Thr Asn Leu Pro Ser Asn Thr Ala Phe Arg Gly 
             900                905                910
Phe Gly Gly Pro Gln Gly Met Leu Ile Ala Glu Tyr Trp Met Ser Glu 
         915                920                925
Val Ala Ile Thr Cys Gly Leu Pro Ala Glu Glu Val Arg Arg Lys Asn 
     930                935                940
Met Tyr Lys Glu Gly Asp Leu Thr His Phe Asn Gln Lys Leu Glu Gly 
 945                950                955                960
Phe Thr Leu Pro Arg Cys Trp Asp Glu Cys Ile Ala Ser Ser Gln Tyr 
                 965                970                975
Leu Ala Arg Lys Arg Glu Val Glu Lys Phe Asn Arg Glu Asn Cys Trp 
             980                985                990
Lys Lys Arg Gly Leu Cys Ile Ile Pro Thr Lys Phe Gly Ile Ser Phe 
         995                1000                1005
Thr Leu Pro Phe Leu Asn Gln Gly Gly Ala Leu Val His Val Tyr Thr 
     1010                1015                1020
Asp Gly Ser Val Leu Leu Thr His Gly Gly Thr Glu Met Gly Gln Gly 
 1025                1030                1035                1040
Leu His Thr Lys Met Val Gln Val Ala Ser Arg Ala Leu Lys Ile Pro 
                 1045                1050                1055
Thr Ser Lys Ile His Ile Ser Glu Thr Ser Thr Asn Thr Val Pro Asn 
             1060                1065                1070
Thr Ser Pro Thr Ala Ala Ser Ala Ser Ala Asp Leu Asn Gly Gln Gly 
         1075                1080                1085
Val Tyr Glu Ala Cys Gln Thr Ile Leu Lys Arg Leu Glu Pro Phe Lys 
     1090                1095                1100
Lys Lys Lys Pro Thr Gly Pro Trp Glu Ala Trp Val Met Asp Ala Tyr 
 1105                1110                1115                1120
Thr Ser Ala Val Ser Leu Ser Ala Thr Gly Phe Tyr Lys Thr Pro Asn 
                 1125                1130                1135
Leu Gly Tyr Ser Phe Glu Thr Asn Ser Gly Asn Pro Phe His Tyr Phe 
             1140                1145                1150
Ser Tyr Gly Val Ala Cys Ser Glu Val Glu Ile Asp Cys Leu Thr Gly 
         1155                1160                1165
Asp His Lys Asn Leu Arg Thr Asp Ile Val Met Asp Val Gly Ser Ser 
     1170                1175                1180
Leu Asn Pro Ala Ile Asp Ile Gly Gln Val Glu Gly Ala Phe Val Gln 
 1185                1190                1195                1200
Gly Leu Gly Leu Phe Thr Met Glu Glu Leu His Tyr Ser Pro Glu Gly 
                 1205                1210                1215
Ser Leu His Thr Arg Gly Pro Ser Thr Tyr Lys Ile Pro Ala Phe Gly 
             1220                1225                1230
Ser Ile Pro Ile Glu Phe Arg Val Ser Leu Leu Arg Asp Cys Pro Asn 
         1235                1240                1245
Lys Arg Ala Ile Tyr Ala Ser Lys Ala Val Gly Glu Pro Pro Leu Phe 
     1250                1255                1260
Leu Ala Ser Ser Ile Phe Phe Ala Ile Lys Asp Ala Ile Arg Ala Ala 
 1265                1270                1275                1280
Arg Ala Gln His Gly Asp Asn Ala Lys Gln Leu Phe Gln Leu Asp Ser 
                 1285                1290                1295
Pro Ala Thr Pro Glu Lys Ile Arg Asn Ala Cys Val Asp Gln Phe Thr 
             1300                1305                1310
Thr Leu Cys Val Thr Gly Val Pro Glu Asn Cys Lys Ser Trp Ser Val 
         1315                1320                1325
Arg Ile 
     1330



<210> 6978
<211> 4404
<212> DNA
<213> Homo sapiens
<308> D11456
<400> 6978

cgaattccg  ctcttagga  tgaggtacc  ggagttcgg  gaccccaac  tgtgacaat  60
acagcagac  aattggttt  ctttgtgaa  ggcagaaag  tggtggaga  aaatgcaga  120
ccagagaca  cccttttgg  ctacctgag  agaaagttg  ggctgagtg  aaccaagct  180
ggctgtgga  aggggggct  cggggcttg  acagtgatg  tctccaagt  tgatcgtct  240
cagaacaag  tcgtccact  ttctgccaa  gcctgcctg  cccccatct  ctccttgca  300
catgttgca  tgacaactg  ggaaggaat  ggaagcacc  agacgaggc  gcatcctgt  360
caggagaga  ttgccaaaa  ccacggctc  cagtgcggg  tctgcaccc  tggcatcgt  420
atgagtatg  acacactgc  ccggaatca  cccgagccc  ccatggagg  gattgagaa  480
gccttccaa  gaaatctgt  ccgctgcac  ggctacaga  ccatcctcc  gggcttccg  540
acctttgcc  gggatggtg  atgctgtgg  ggagatggg  ataatccaa  ttgctgcat  600
aaccagaag  aagaccact  agtcagcct  tcgccatct  tattcaaac  agaggagtt  660
acgcccctg  atccaaccc  ggagcccat  tttccccca  agttgctga  gctgaaaga  720
actcctcgg  agcagctgc  atttgaagg  gagcgtgtg  cgtggatac  ggcctcaac  780
ctcaaggag  tgctggacc  caaggctca  caccctgac  ccaagctgg  cgtggggaa  840
acggagatt  gcattgaga  gaagttcaa  aatatgctg  ttcctatga  tgtctgccc  900
gcctggatc  ctgagctga  ttcggtaga  catggaccc  acggtatct  ctttggagc  960
gcttgcccc  tgagcattg  ggaaaaaac  ctggtggat  ctgttgcta  gcttcctgc  1020
caaaagaca  aggtgttca  aggggtcct  gagcagctg  gctggtttg  tgggaagca  1080
gtcaagtct  tggcgtccg  tggagggaa  atcatcact  ccagcccca  ctccgacct  1140
aaccccgtg  tcatggcca  tggggccaa  ctgacactt  tgtccagag  caccaggag  1200
actgtccag  tggaccaca  cttcttccc  ggctacaga  agaccctgc  gagcccgga  1260
gagatactg  tctccatag  gatccccta  agcagggag  gggagtatt  ctcagcatt  1320
aagcaggcc  cccggagag  agatgacat  gccaaggta  ccagtggca  gagagtttt  1380
ttcaagcca  gaaccacag  ggtacagga  ctggccctt  gctatggtg  aatggccaa  1440
agaaccatc  cagccctca  gaccactca  aggcagctt  ccaagctct  gaaggagga  1500
ctgctgcag  acgtgtgtg  aggactggc  gaggagctg  atctgcctc  cgatgcccc  1560
ggtggcatg  tggacttcc  gtgcaccct  accctcagc  tcttcttca  gttctacct  1620
acagtcctt  agaagctgg  ccaagagaa  ctggaagac  agtgtggta  actggaccc  1680
actttcgcc  gtgcaactt  actgtttca  aaagacccc  cagccgatg  ccagctctt  1740
caagaggtg  ccaagggtc  gtctgagga  gacatggtg  gccggcccc  gccccacct  1800
gcagcggac  tgcaggcct  tggtgaggc  gtgtactgt  acgacattc  tcgctacga  1860
aatgagctg  ctctccggc  ggtcaccag  acccgggcc  acgccaaga  caagtccat  1920
gatacatca  aagctaaga  ggttccagg  tttgtttgt  tcatttccg  tgatgatgt  1980
cctgggagt  acataactg  aatttgtaa  gatgagaca  tctttgcga  ggataaggt  2040
acttgtgtt  ggcatatca  tggtgctgt  gttgctgac  ccccggaac  cacacagag  2100
gctgcccaa  gggtgaaaa  cacctatga  gaactacca  ccattatca  aattgagga  2160
gctataaag  acaactcct  ttatggacc  gagctgaag  tcgagaaag  ggacctaaa  2220
aaggggttt  ccgaagcag  taatgttgt  tcaggggag  tatacatcg  tggccaaga  2280
cacttctac  tggagactc  ctgcaccat  gctgttcca  aaggcgagg  aggggagat  2340
gagctcttt  tgtctacac  gaacaccat  aagacccag  gctttgttg  aaaaatgtt  2400
ggggttcca  caaaccgga  tgtggttcg  gtgaagaga  tgggaggag  ctttggagg  2460
aaggagacc  ggagcactg  ggtgtccac  gcagtggcc  tggctgcat  taagaccgg  2520
cgccctgtg  gatgcatgc  ggaccgtga  gaggacatg  tgataactg  tggcagaca  2580
cccttcctg  ccagataca  ggttggctt  atgaagact  ggacagttg  ggctcttga  2640
gtggaccac  tcagcaatg  ggggaacac  caggatctc  ctcagagta  tatggaacg  2700
gctttattc  acatggaca  ctgctataa  atccccaac  tccggggca  tgggcggct  2760
tgcaaaacc  accttccct  caacacggc  ttccggggc  ttggggggc  ccaggggat  2820
ctcattgcc  agtgctgga  gagtgaagt  gcagtgacc  gtgggatgc  tgcagagga  2880
gtgcggaga  aaaacctgt  caaagaagg  gacctgaca  acttcaacc  gaagcttga  2940
ggtttcacc  tgcccagat  ctgggaaga  tgcctagca  gctctcagt  tcatgctcg  3000
aagagtgag  ttgacaagt  caacaagga  aattgttgg  aaaagagag  attgtgcat  3060
attcccacc  agtttggaa  aagcttcac  gttcctttt  tgaatcagg  aggagccct  3120
cttcatgtg  acacagatg  ctctgtgct  ctgacccac  gggggactg  gatgggcca  3180
ggccttcat  ccaaaatgg  ccaggtggc  agtagagct  tgaaaatcc  cacctctaa  3240
atttatatc  gcgagacaa  cactaacac  gtgcccaac  cctctccca  ggctgcctc  3300
gtcagcgct  acctcaatg  acaggccgt  tatgcggct  gtcagacca  cttgaaaag  3360
ctggaaccc  acaagaaga  gaatcccag  ggctcctgg  aagactggg  cacagctgc  3420
tacatggac  cagtgagct  gtctgccac  gggttttat  gaacaccca  tctgggcta  3480
agctttgag  ctaactcag  gaacccctt  cactacttc  gctatgggg  ggcttgctc  3540
gaagtagaa  tcgactgcc  aacaggaga  cataagaac  tccgcacag  tattgtcat  3600
gatgttggc  ccagtctaa  ccctgccat  gatattgga  aggtggaag  ggcatttgt  3660
cagggcctt  gcctcttca  cctagagga  ctacactat  cccccgagg  gagcctgca  3720
acccgtggc  ctagcacct  caagatccc  gcatttggc  gcatcccca  tgagttcag  3780
gtgtccctg  tccgcgact  ccccaacaa  aaggccatc  atgcatcga  ggctgttgg  3840
gagccgccc  tcttcctgg  tgcttctat  ttctttgcc  tcaaagatg  catccgtgc  3900
gctcgagct  agcacacag  taataacgt  aaggaactc  tccggctag  cagccctgc  3960
accccggag  agatccgca  tgcctgcgt  gacaagttc  ccaccctgt  tgtcactgg  4020
gtcccagaa  actgcaaac  ctggtctgt  agggtctaa  gagagagtc  tcagcagag  4080
cttcttgtg  tgcctttgg  cttccatgg  gcaggagga  cataccaca  aacatggat  4140
tattaaagt  acagaatga  agacctgtg  tttgtcaag  tgggatttg  aagacaagt  4200
aatgcaatg  aagattttg  tcaaaaatg  aatttgtaa  cacaatgat  agcaaattc  4260
aaactgtta  gcctaaatg  tgaatatgc  attaggatc  ttttctgtc  gttttaatc  4320
tgtatctgg  atagggtcg  gaagggttt  tgctattcc  cacttactg  acagcctgt  4380
taacctcaa  aaaaaaaaa  aaaa  4404



<210> 6979
<211> 1332
<212> PRT
<213> Homo sapiens
<308> P47989
<400> 6979

Thr Ala Asp Lys Leu Val Phe Phe Val Asn Gly Arg Lys Val Val Glu 
  1               5                  10                  15
Lys Asn Ala Asp Pro Glu Thr Thr Leu Leu Ala Tyr Leu Arg Arg Lys 
             20                  25                  30
Leu Gly Leu Ser Gly Thr Lys Leu Gly Cys Gly Glu Gly Gly Cys Gly 
         35                  40                  45
Ala Cys Thr Val Met Leu Ser Lys Tyr Asp Arg Leu Gln Asn Lys Ile 
     50                  55                  60
Val His Phe Ser Ala Asn Ala Cys Leu Ala Pro Ile Cys Ser Leu His 
 65                  70                  75                  80
His Val Ala Val Thr Thr Val Glu Gly Ile Gly Ser Thr Lys Thr Arg 
                 85                  90                  95
Leu His Pro Val Gln Glu Arg Ile Ala Lys Ser His Gly Ser Gln Cys 
             100                105                110
Gly Phe Cys Thr Pro Gly Ile Val Met Ser Met Tyr Thr Leu Leu Arg 
         115                120                125
Asn Gln Pro Glu Pro Thr Met Glu Glu Ile Glu Asn Ala Phe Gln Gly 
     130                135                140
Asn Leu Cys Arg Cys Thr Gly Tyr Arg Pro Ile Leu Gln Gly Phe Arg 
 145                150                155                160
Thr Phe Ala Arg Asp Gly Gly Cys Cys Gly Gly Asp Gly Asn Asn Pro 
                 165                170                175
Asn Cys Cys Met Asn Gln Lys Lys Asp His Ser Val Ser Leu Ser Pro 
             180                185                190
Ser Leu Phe Lys Pro Glu Glu Phe Thr Pro Leu Asp Pro Thr Gln Glu 
         195                200                205
Pro Ile Phe Pro Pro Glu Leu Leu Arg Leu Lys Asp Thr Pro Arg Lys 
     210                215                220
Gln Leu Arg Phe Glu Gly Glu Arg Val Thr Trp Ile Gln Ala Ser Thr 
 225                230                235                240
Leu Lys Glu Leu Leu Asp Leu Lys Ala Gln His Pro Asp Ala Lys Leu 
                 245                250                255
Val Val Gly Asn Thr Glu Ile Gly Ile Glu Met Lys Phe Lys Asn Met 
             260                265                270
Leu Phe Pro Met Ile Val Cys Pro Ala Trp Ile Pro Glu Leu Asn Ser 
         275                280                285
Val Glu His Gly Pro Asp Gly Ile Ser Phe Gly Ala Ala Cys Pro Leu 
     290                295                300
Ser Ile Val Glu Lys Thr Leu Val Asp Ala Val Ala Lys Leu Pro Ala 
 305                310                315                320
Gln Lys Thr Glu Val Phe Arg Gly Val Leu Glu Gln Leu Arg Trp Phe 
                 325                330                335
Ala Gly Lys Gln Val Lys Ser Val Ala Ser Val Gly Gly Asn Ile Ile 
             340                345                350
Thr Ala Ser Pro Ile Ser Asp Leu Asn Pro Val Phe Met Ala Ser Gly 
         355                360                365
Ala Lys Leu Thr Leu Val Ser Arg Gly Thr Arg Arg Thr Val Gln Met 
     370                375                380
Asp His Thr Phe Phe Pro Gly Tyr Arg Lys Thr Leu Leu Ser Pro Glu 
 385                390                395                400
Glu Ile Leu Leu Ser Ile Glu Ile Pro Tyr Ser Arg Glu Gly Glu Tyr 
                 405                410                415
Phe Ser Ala Phe Lys Gln Ala Ser Arg Arg Glu Asp Asp Ile Ala Lys 
             420                425                430
Val Thr Ser Gly Met Arg Val Leu Phe Lys Pro Gly Thr Thr Glu Val 
         435                440                445
Gln Glu Leu Ala Leu Cys Tyr Gly Gly Met Ala Asn Arg Thr Ile Ser 
     450                455                460
Ala Leu Lys Thr Thr Gln Arg Gln Leu Ser Lys Leu Trp Lys Glu Glu 
 465                470                475                480
Leu Leu Gln Asp Val Cys Ala Gly Leu Ala Glu Glu Leu His Leu Pro 
                 485                490                495
Pro Asp Ala Pro Gly Gly Met Val Asp Phe Arg Cys Thr Leu Thr Leu 
             500                505                510
Ser Phe Phe Phe Lys Phe Tyr Leu Thr Val Leu Gln Lys Leu Gly Gln 
         515                520                525
Glu Asn Leu Glu Asp Lys Cys Gly Lys Leu Asp Pro Thr Phe Ala Ser 
     530                535                540
Ala Thr Leu Leu Phe Gln Lys Asp Pro Pro Ala Asp Val Gln Leu Phe 
 545                550                555                560
Gln Glu Val Pro Lys Gly Gln Ser Glu Glu Asp Met Val Gly Arg Pro 
                 565                570                575
Leu Pro His Leu Ala Ala Asp Met Gln Ala Ser Gly Glu Ala Val Tyr 
             580                585                590
Cys Asp Asp Ile Pro Arg Tyr Glu Asn Glu Leu Ser Leu Arg Leu Val 
         595                600                605
Thr Ser Thr Arg Ala His Ala Lys Ile Lys Ser Ile Asp Thr Ser Glu 
     610                615                620
Ala Lys Lys Val Pro Gly Phe Val Cys Phe Ile Ser Ala Asp Asp Val 
 625                630                635                640
Pro Gly Ser Asn Ile Thr Gly Ile Cys Asn Asp Glu Thr Val Phe Ala 
                 645                650                655
Lys Asp Lys Val Thr Cys Val Gly His Ile Ile Gly Ala Val Val Ala 
             660                665                670
Asp Thr Pro Glu His Thr Gln Arg Ala Ala Gln Gly Val Lys Ile Thr 
         675                680                685
Tyr Glu Glu Leu Pro Ala Ile Ile Thr Ile Glu Asp Ala Ile Lys Asn 
     690                695                700
Asn Ser Phe Tyr Gly Pro Glu Leu Lys Ile Glu Lys Gly Asp Leu Lys 
 705                710                715                720
Lys Gly Phe Ser Glu Ala Asp Asn Val Val Ser Gly Glu Ile Tyr Ile 
                 725                730                735
Gly Gly Gln Glu His Phe Tyr Leu Glu Thr His Cys Thr Ile Ala Val 
             740                745                750
Pro Lys Gly Glu Ala Gly Glu Met Glu Leu Phe Val Ser Thr Gln Asn 
         755                760                765
Thr Met Lys Thr Gln Ser Phe Val Ala Lys Met Leu Gly Val Pro Ala 
     770                775                780
Asn Arg Ile Val Val Arg Val Lys Arg Met Gly Gly Gly Phe Gly Gly 
 785                790                795                800
Lys Glu Thr Arg Ser Thr Val Val Ser Thr Ala Val Ala Leu Ala Ala 
                 805                810                815
Tyr Lys Thr Gly Arg Pro Val Arg Cys Met Leu Asp Arg Asp Glu Asp 
             820                825                830
Met Leu Ile Thr Gly Gly Arg His Pro Phe Leu Ala Arg Tyr Lys Val 
         835                840                845
Gly Phe Met Lys Thr Gly Thr Val Val Ala Leu Glu Val Asp His Phe 
     850                855                860
Ser Asn Val Gly Asn Thr Gln Asp Leu Ser Gln Ser Ile Met Glu Arg 
 865                870                875                880
Ala Leu Phe His Met Asp Asn Cys Tyr Lys Ile Pro Asn Ile Arg Gly 
                 885                890                895
Thr Gly Arg Leu Cys Lys Thr Asn Leu Pro Ser Asn Thr Ala Phe Arg 
             900                905                910
Gly Phe Gly Gly Pro Gln Gly Met Leu Ile Ala Glu Cys Trp Met Ser 
         915                920                925
Glu Val Ala Val Thr Cys Gly Met Pro Ala Glu Glu Val Arg Arg Lys 
     930                935                940
Asn Leu Tyr Lys Glu Gly Asp Leu Thr His Phe Asn Gln Lys Leu Glu 
 945                950                955                960
Gly Phe Thr Leu Pro Arg Cys Trp Glu Glu Cys Leu Ala Ser Ser Gln 
                 965                970                975
Tyr His Ala Arg Lys Ser Glu Val Asp Lys Phe Asn Lys Glu Asn Cys 
             980                985                990
Trp Lys Lys Arg Gly Leu Cys Ile Ile Pro Thr Lys Phe Gly Ile Ser 
         995                1000                1005
Phe Thr Val Pro Phe Leu Asn Gln Ala Gly Ala Leu Leu His Val Tyr 
     1010                1015                1020
Thr Asp Gly Ser Val Leu Leu Thr His Gly Gly Thr Glu Met Gly Gln 
 1025                1030                1035                1040
Gly Leu His Thr Lys Met Val Gln Val Ala Ser Arg Ala Leu Lys Ile 
                 1045                1050                1055
Pro Thr Ser Lys Ile Tyr Ile Ser Glu Thr Ser Thr Asn Thr Val Pro 
             1060                1065                1070
Asn Thr Ser Pro Thr Ala Ala Ser Val Ser Ala Asp Leu Asn Gly Gln 
         1075                1080                1085
Ala Val Tyr Ala Ala Cys Gln Thr Ile Leu Lys Arg Leu Glu Pro Tyr 
     1090                1095                1100
Lys Lys Lys Asn Pro Ser Gly Ser Trp Glu Asp Trp Val Thr Ala Ala 
 1105                1110                1115                1120
Tyr Met Asp Thr Val Ser Leu Ser Ala Thr Gly Phe Tyr Arg Thr Pro 
                 1125                1130                1135
Asn Leu Gly Tyr Ser Phe Glu Thr Asn Ser Gly Asn Pro Phe His Tyr 
             1140                1145                1150
Phe Ser Tyr Gly Val Ala Cys Ser Glu Val Glu Ile Asp Cys Leu Thr 
         1155                1160                1165
Gly Asp His Lys Asn Leu Arg Thr Asp Ile Val Met Asp Val Gly Ser 
     1170                1175                1180
Ser Leu Asn Pro Ala Ile Asp Ile Gly Gln Val Glu Gly Ala Phe Val 
 1185                1190                1195                1200
Gln Gly Leu Gly Leu Phe Thr Leu Glu Glu Leu His Tyr Ser Pro Glu 
                 1205                1210                1215
Gly Ser Leu His Thr Arg Gly Pro Ser Thr Tyr Lys Ile Pro Ala Phe 
             1220                1225                1230
Gly Ser Ile Pro Ile Glu Phe Arg Val Ser Leu Leu Arg Asp Cys Pro 
         1235                1240                1245
Asn Lys Lys Ala Ile Tyr Ala Ser Lys Ala Val Gly Glu Pro Pro Leu 
     1250                1255                1260
Phe Leu Ala Ala Ser Ile Phe Phe Ala Ile Lys Asp Ala Ile Arg Ala 
 1265                1270                1275                1280
Ala Arg Ala Gln His Thr Gly Asn Asn Val Lys Glu Leu Phe Arg Leu 
                 1285                1290                1295
Asp Ser Pro Ala Thr Pro Glu Lys Ile Arg Asn Ala Cys Val Asp Lys 
             1300                1305                1310
Phe Thr Thr Leu Cys Val Thr Gly Val Pro Glu Asn Cys Lys Pro Trp 
         1315                1320                1325
Ser Val Arg Val 
     1330



<210> 6980
<211> 617
<212> DNA
<213> Rattus norvegicus
<308> AI172411
<400> 6980

gctgcagaa  gacgtttat  gggcagatg  ggtgcgaga  atgccagtg  acagagtga  60
aagaaggca  gtcctccag  gagggggat  gtgtccctg  ctgggagcc  aagcctgaa  120
gcactaagg  ctggcacca  agacgggct  aggggaggc  cgcccacaa  ggcttcggg  180
ccctccttc  tggagacac  acccctgac  tggagcaca  ggccatcgt  ctcaccgtt  240
tctcggctc  tctcaggag  actgtggga  ggggttgga  acttaggag  gtccttcag  300
agggatgaa  gaggctggt  gcatagtga  cccggatgt  tcatgtggg  atatgggag  360
tgctggccc  aagaatgat  ttcaggttt  agcaggacc  ttggactta  aacttgtgt  420
tgctttggg  ttatttgga  cgggaagct  gagaaagtg  gaaggtgtt  taccaaacc  480
tgagcacag  tggtctgtc  ctgggttcc  ggcaggcag  gcatggcac  cagtgggac  540
gttgccaca  gtgcacagt  gtacaggca  acagttgtg  caagcttgt  ttttatgta  600
taaggaagg  aatctgg  617



<210> 6981
<211> 226
<212> PRT
<213> Rattus norvegicus
<308> P23764
<400> 6981

Met Ser Arg Ile Leu Arg Ala Ser Cys Leu Leu Ser Leu Leu Leu Ala 
  1               5                  10                  15
Gly Phe Val Pro Pro Gly Arg Gly Gln Glu Lys Ser Lys Thr Asp Cys 
             20                  25                  30
His Gly Gly Met Ser Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr Ile 
         35                  40                  45
Asp Gly Glu Glu Tyr Ile Pro Phe Lys Gln Tyr Ala Gly Lys Tyr Ile 
     50                  55                  60
Leu Phe Val Asn Val Ala Ser Tyr Cys Gly Leu Thr Asp Gln Tyr Leu 
 65                  70                  75                  80
Glu Leu Asn Ala Leu Gln Glu Glu Leu Gly Pro Phe Gly Leu Val Ile 
                 85                  90                  95
Leu Gly Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Glu Asn 
             100                105                110
Ser Glu Ile Leu Pro Ser Leu Lys Tyr Val Arg Pro Gly Gly Gly Phe 
         115                120                125
Val Pro Asn Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys 
     130                135                140
Glu Gln Lys Phe Tyr Thr Phe Leu Lys Asn Ser Cys Pro Pro Thr Ala 
 145                150                155                160
Glu Leu Leu Gly Ser Pro Gly Arg Leu Phe Trp Glu Pro Met Lys Ile 
                 165                170                175
His Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly 
             180                185                190
Ile Pro Ile Met Arg Trp Tyr His Arg Thr Thr Val Ser Asn Val Lys 
         195                200                205
Met Asp Ile Leu Ser Tyr Met Arg Arg Gln Ala Ala Leu Gly Ala Arg 
     210                215                220
Gly Lys 
 225



<210> 6982
<211> 373
<212> DNA
<213> Homo sapiens
<308> AI245240
<400> 6982

ttttttttt  ttttttttt  ttttttttt  gcggcaaaa  ggctttaac  gggcaaacg  60
ggggagccc  aacccaggg  accagggag  ggggagggc  cgccccccg  aggagcagg  120
ggggcatcc  tgcccaggg  cctaaccct  aaggcacta  gggctggcc  ctcaaacag  180
ctcagggag  cccgcccac  agggcttgg  gcccctccc  catgaaaac  ccacccctg  240
cagggggcc  ggggccctt  ctatcacat  tgcctgtgg  gaactcaag  aggtgatcc  300
tctcaggga  aactggggg  gggggagga  ccttgggag  gcccttcag  aaataggaa  360
gggggggtg  gga  373



<210> 6983
<211> 226
<212> PRT
<213> Homo sapiens
<308> P22352
<400> 6983

Met Ala Arg Leu Leu Gln Ala Ser Cys Leu Leu Ser Leu Leu Leu Ala 
  1               5                  10                  15
Gly Phe Val Ser Gln Ser Arg Gly Gln Glu Lys Ser Lys Met Asp Cys 
             20                  25                  30
His Gly Gly Ile Ser Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr Ile 
         35                  40                  45
Asp Gly Glu Glu Tyr Ile Pro Phe Lys Gln Tyr Ala Gly Lys Tyr Val 
     50                  55                  60
Leu Phe Val Asn Val Ala Ser Tyr Cys Gly Leu Thr Gly Gln Tyr Ile 
 65                  70                  75                  80
Glu Leu Asn Ala Leu Gln Glu Glu Leu Ala Pro Phe Gly Leu Val Ile 
                 85                  90                  95
Leu Gly Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Glu Asn 
             100                105                110
Ser Glu Ile Leu Pro Thr Leu Lys Tyr Val Arg Pro Gly Gly Gly Phe 
         115                120                125
Val Pro Asn Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys 
     130                135                140
Glu Gln Lys Phe Tyr Thr Phe Leu Lys Asn Ser Cys Pro Pro Thr Ser 
 145                150                155                160
Glu Leu Leu Gly Thr Ser Asp Arg Leu Phe Trp Glu Pro Met Lys Val 
                 165                170                175
His Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly 
             180                185                190
Ile Pro Ile Met Arg Trp His His Arg Thr Thr Val Ser Asn Val Lys 
         195                200                205
Met Asp Ile Leu Ser Tyr Met Arg Arg Gln Ala Ala Leu Gly Val Lys 
     210                215                220
Arg Lys 
 225



<210> 6984
<211> 441
<212> DNA
<213> Rattus norvegicus
<308> AI175764
<400> 6984

atgcttaaa  atatatatg  attggggca  ggttaatcc  ggctaatta  aatatgcat  60
acctcaaaa  atgatcaaa  ctttctcat  atactgtac  ggaatagtt  aaatgcatc  120
ttaacattc  gattgcatt  tccagtagt  aatcaacag  atattaaat  tttgcccaa  180
aaacttttg  aacaggaac  caaaagccc  aaactcagc  actcttggg  ctcccatct  240
cagttctct  aatcctggc  aaaacagcg  ccttaaaaa  ttttttccg  tcgtaagcc  300
ggcccaggg  agccatgca  tcgatgaaa  acgtggtga  attgatgtg  cagcggtac  360
cactggcaa  gtagtccta  gggaaggcc  gatggtagt  gtggaaacc  ttgcccacg  420
tacccaggg  aaccaggat  t  441



<210> 6985
<211> 358
<212> PRT
<213> Rattus norvegicus
<308> P07308
<400> 6985

Met Pro Ala His Met Leu Gln Glu Ile Ser Ser Ser Tyr Thr Thr Thr 
  1               5                  10                  15
Thr Thr Ile Thr Glu Pro Pro Ser Gly Asn Leu Gln Asn Gly Arg Glu 
             20                  25                  30
Lys Met Lys Lys Val Pro Leu Tyr Leu Glu Glu Asp Ile Arg Pro Glu 
         35                  40                  45
Met Arg Glu Asp Ile His Asp Pro Ser Tyr Gln Asp Glu Glu Gly Pro 
     50                  55                  60
Pro Pro Lys Leu Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ala Leu 
 65                  70                  75                  80
Leu His Val Gly Ala Leu Tyr Gly Ile Thr Leu Ile Pro Ser Ser Lys 
                 85                  90                  95
Val Tyr Thr Leu Leu Trp Gly Ile Phe Tyr Tyr Leu Ile Ser Ala Leu 
             100                105                110
Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Thr Tyr Lys 
         115                120                125
Ala Arg Leu Pro Leu Arg Ile Phe Leu Ile Ile Ala Asn Thr Met Ala 
     130                135                140
Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His His 
 145                150                155                160
Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly Phe 
                 165                170                175
Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala Val 
             180                185                190
Lys Glu Lys Gly Gly Lys Leu Asp Met Ser Asp Leu Lys Ala Glu Lys 
         195                200                205
Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Leu Met 
     210                215                220
Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Cys Trp Gly Glu Thr 
 225                230                235                240
Phe Leu His Ser Leu Phe Val Ser Thr Phe Leu Arg Tyr Thr Leu Val 
                 245                250                255
Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Tyr Gly Tyr 
             260                265                270
Arg Pro Tyr Asp Lys Asn Ile Gln Ser Arg Glu Asn Ile Leu Val Ser 
         275                280                285
Leu Gly Ser Val Gly Glu Gly Phe His Asn Tyr His His Ala Phe Pro 
     290                295                300
Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr Thr 
 305                310                315                320
Phe Phe Ile Asp Cys Met Ala Ala Leu Gly Leu Ala Tyr Asp Arg Lys 
                 325                330                335
Lys Val Ser Lys Ala Ala Val Leu Ala Arg Ile Lys Arg Thr Gly Asp 
             340                345                350
Gly Ser His Lys Ser Ser 
         355



<210> 6986
<211> 5221
<212> DNA
<213> Homo sapiens
<308> AF097514
<400> 6986

ataaaaggg  gctgaggaa  taccggaca  ggtcacccg  tgccagctc  agcctttaa  60
ttcccggct  ggggacctc  acgcaccgc  gctagcgcc  acaaccagc  agcgtgcaa  120
gcgccgcgg  tcagcgcgt  ccggcgggc  tcgaaaccg  agtcctccg  cgaccccga  180
ctccgctcc  gagcctcag  cccctggaa  gtgatcccg  catccgaga  ccaagatgc  240
ggcccactt  ctgcaggac  atatctcta  ctcctatac  accaccacc  ccattacag  300
gcctccctc  agggtcctg  agaatggag  agataagtt  gagacgatg  ccctctact  360
ggaagacga  attcgccct  atataaaag  tgatatata  gaccccacc  acaaggata  420
ggaaggccc  agccccaag  ttgaatatg  ctggagaaa  atcatcctt  tgtctctgc  480
acacttggg  gccctgtat  ggatcactt  gattcctac  tgcaagttc  acacctggc  540
ttggggggt  ttctactat  ttgtcagtg  cctgggcat  acagcagga  ctcatcgtc  600
gtggagcca  cgctcttac  aagctcggc  gcccctacg  ctctttctg  tcattgcca  660
cacaatggc  ttccagaat  atgtctatg  atgggctcg  gaccaccgt  cccaccaca  720
gttttcaga  acacatgct  atcctcata  ttcccgacg  ggctttttc  tctctcacg  780
gggttggct  cttgtgcgc  aacacccag  tgtcaaaga  aaggggagt  cgctagact  840
gtctgacct  gaagctgag  aactggtga  gttccagag  aggtactac  aacctggct  900
gctgctgat  tgcttcatc  tgcccacgc  tgtgccctg  tatttctgg  gtgaaactt  960
tcaaaacag  gtgttcgtt  ccactttct  gcgatatgc  gtggtgctt  atgccacct  1020
gctggtgaa  agtgctgcc  acctcttcg  atatcgtcc  tatgacaag  acattagcc  1080
ccgggagaa  atcctggtt  cacttggag  tgtgggtga  ggcttccac  actaccacc  1140
ctcctttcc  tatgactac  ctgccagtg  gtaccgctg  cacatcaac  tcaccacat  1200
cttcattga  tgcatggcc  ccctcggtc  ggcctatga  cggaagaaa  tctccaagg  1260
cgccatctt  gccaggatt  aaagaaccg  agatggaaa  tacaagagt  gctgagttt  1320
gggtccctc  ggtttcctt  ttcaaaaac  agccaggca  aggttttaa  gtctgttta  1380
taactactg  ataatgcta  caggatgct  aagatgatg  tgttaaccc  ttccagtac  1440
gtattcttt  aaaattcaa  agtattgaa  gccaacaac  ctgccttta  gatgctaag  1500
tgatattat  tcttctctt  tcctctctc  cttctaggc  cattgtcct  cttttcact  1560
tattgctat  gccctcctt  cccttattg  ctcccaggc  agcagctgg  cagtctttg  1620
tcagtgtcc  gcttccaaa  cctagacaa  ctttctgta  cctaaaacg  atggtcttt  1680
ctccagata  ctctctttc  ttgagctgt  gtgagcttt  aagtaggtg  cttgagcta  1740
agataaaac  gaatcttct  ggtagtccc  tgttgatta  cttcagccc  ggcttttgc  1800
agatggaat  gaaaagcaa  ttcatttga  acaaagctt  taaagcagg  aaattgtcg  1860
gggagagag  tagcatgta  gaatgtaag  atgagggaa  cgaagcaag  ggaacctct  1920
gccatgatc  gacatacag  tgcctacct  atgaggact  caagcccca  cacatagca  1980
gcttccttt  tctcctggc  cggggtaaa  agtggctgc  gtgtttggc  atgctaatt  2040
aatgccgca  catatagtt  aggccgagg  taaagaaaa  acattttaa  tttgtagta  2100
aagtggtct  tgctgggga  gggttttct  ttctttttt  ctttaataa  aaggagatt  2160
cttagttca  atatcaaga  gtcttgaag  tgggtgttt  cagaattgg  aaaaacagc  2220
gctcatgga  ttttgagta  tccatgagc  gctcattac  gttctttcc  ctttctgct  2280
tgccatctt  aggatattg  ttcttcccc  catagtaat  agatggctg  ggcatttcc  2340
aacatccaa  aaaagggaa  gatttaagg  ggtgaagtc  ggtcaaaaa  aaaatatat  2400
tacatatat  cattgctta  aacgttaaa  tattagagt  tttcccttc  aaagaggga  2460
gtttggaaa  aactctgaa  gagaggagg  attagttgg  atgccaatt  cctctccac  2520
gctggacat  agatggaga  gctgaggga  aggatctat  ggcagcttc  aagagcgaa  2580
ttcacatag  aagggatct  agaacacgt  gccaggggc  tgagaaggt  actgagtga  2640
ttattggga  tcttaataa  ataaactag  tattaggtc  attcattaa  tagttccag  2700
ttctccttg  aatgagtaa  aactagaag  cttctctcc  cagtgttgt  ccccttcac  2760
cattttttt  tgaggagaa  ggggtctct  ttaacatct  gcctaaagt  tacaactgc  2820
tggggggca  ggttaggaa  ctcttcact  ccctgattc  tgattcctg  ctctaccct  2880
tctgtccct  ttctttgac  agatctttc  cttccctga  cgttttctt  tttccctgg  2940
caggcagcc  cctttgtgt  tattcagag  cagtgatga  ttgctgtcc  ggcagctcc  3000
tcctgcaca  agaatgctc  gggtcactg  accactgct  ctcttttga  agtagagct  3060
gctgccact  tcacgtggc  tccgcagtg  ctccaccta  acccctgtg  tcccctgcc  3120
cactgatgg  tcaagacaa  gctggcaaa  cctcccaga  acatctctg  cccagaaag  3180
ctctctctc  ctccctctc  catgaggca  agccaagcc  agcgctcat  ttgagccag  3240
gggccagcc  cagagcaaa  gagggttta  tttcagtcc  ctctctctg  gtcagaacc  3300
gagggcatg  tgaatgccc  ctgcttact  ggtgagggt  ccccgcctg  gtcagtgct  3360
tcagctggc  gtgcaatgc  tgtagaagt  ggaggaaac  gttctcact  ggaagaagc  3420
agggcaaga  cccaagtgc  tcacctcga  aggaggccc  gttccctgg  gtcagggtg  3480
actgcaaag  tttggctga  acctgggat  tgagatacc  caaaccctg  tgaacacag  3540
gtctgttca  caaactaac  agcattccc  acagcctag  gcagacaat  gtatagaag  3600
ctggaaaaa  acaaaaaca  aatttgaga  ccttggacc  ctcctgtcc  tgtagctca  3660
tcatcaaag  agaagtctg  ctttgctct  ttaagattg  aaatgtaca  taccaaaca  3720
tcagtccac  gttgagccc  agtgctgga  gggaggaag  cctttcttc  gtgttaatt  3780
cgtagaggc  acaggggtt  gcctggact  aaggcatcc  tgtcttttg  gctattcac  3840
tcagtagaa  aggatctaa  ggaagatca  tgtagttta  ttctgttga  ctgtgcacc  3900
accccttgg  aatgtctgc  ggtatttct  attccacag  tcatcagat  cctgcttga  3960
aatatataa  caataaaaa  aactttcac  tcttcctat  gtaatcgtg  gccatggat  4020
tgatctgta  catgaccct  cataaggct  gatggcacc  caggctgag  gccccaatg  4080
atgtgtggc  gtgggtgtg  gtgggagtg  gtctgctga  taaggaaca  gattttcaa  4140
attctaaag  tcaattcaa  tgacacatt  atgataaac  cagatctga  caagagtcc  4200
gatttctaa  agtccctgc  ttggggggt  tgctgacaa  ttagctcag  tgccttaca  4260
cttttctaa  cacagtgtt  catatgagc  tgccctcac  ccctctgca  aatcccttt  4320
cacctgaga  cctactgaa  tggctggta  aaaaagggg  ctgagtgga  gattatcag  4380
atcacgatt  gcaggattc  cttctgggc  tcattctgg  aacttttgt  agggctgct  4440
ttcttaagt  cccacattt  atggagggt  gaaataatt  gaatgtatt  gatttataa  4500
ttttttttt  tttttgggt  aaaagatgg  tgtagcatt  aaaatggaa  attttctcc  4560
tggtttgct  gtatcttgg  tgtattctc  gtaagtgta  ctcaaatag  tcatcatga  4620
aggttaaaa  agcgaggtg  ccatgttat  ctggtggtt  aggccaggg  ctctccaac  4680
actgtgcca  tgacttgct  tgtgaccct  ggcaagtca  ttaactata  ggtgcctca  4740
ttttccttc  gttaaaatg  ggataataa  actgaccta  ctcaaaggg  agttttgag  4800
catgactaa  gctttttag  aagcatttt  ggatccttc  gcacaggaa  tctcaagac  4860
tgagtattt  ttataatag  aatgtccac  atgaacttg  tacgtccgt  tgtcccaga  4920
gctgtcatt  gtctatatg  ttctccaag  aactgaatg  atccattgg  gaagcggtg  4980
ataactagc  agacaaaat  tgagaatac  taaacaacg  attgccacg  aaacataca  5040
aggatgcct  ttctgtgat  gggtgggat  ttttccctt  ttatgtggg  tatagtagt  5100
acttgtgac  aaaataatt  tggaataat  tctattaat  tcaactctg  agctaattg  5160
actaatctg  gattgtgtt  gttcataat  aaagtgaag  gaatctaaa  aaaaaaaaa  5220
a  5221



<210> 6987
<211> 359
<212> PRT
<213> Homo sapiens
<308> O00767
<400> 6987

Met Pro Ala His Leu Leu Gln Asp Asp Ile Ser Ser Ser Tyr Thr Thr 
  1               5                  10                  15
Thr Thr Thr Ile Thr Ala Pro Pro Ser Arg Val Leu Gln Asn Gly Gly 
             20                  25                  30
Asp Lys Leu Glu Thr Met Pro Leu Tyr Leu Glu Asp Asp Ile Arg Pro 
         35                  40                  45
Asp Ile Lys Asp Asp Ile Tyr Asp Pro Thr Tyr Lys Asp Lys Glu Gly 
     50                  55                  60
Pro Ser Pro Lys Val Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ser 
 65                  70                  75                  80
Leu Leu His Leu Gly Ala Leu Tyr Gly Ile Thr Leu Ile Pro Thr Cys 
                 85                  90                  95
Lys Phe Tyr Thr Trp Leu Trp Gly Val Phe Tyr Tyr Phe Val Ser Ala 
             100                105                110
Leu Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Ser Tyr 
         115                120                125
Lys Ala Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met 
     130                135                140
Ala Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His 
 145                150                155                160
His Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly 
                 165                170                175
Phe Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala 
             180                185                190
Val Lys Glu Lys Gly Ser Thr Leu Asp Leu Ser Asp Leu Glu Ala Glu 
         195                200                205
Lys Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Met 
     210                215                220
Met Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Phe Trp Gly Glu 
 225                230                235                240
Thr Phe Gln Asn Ser Val Phe Val Ala Thr Phe Leu Arg Tyr Ala Val 
                 245                250                255
Val Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Phe Gly 
             260                265                270
Tyr Arg Pro Tyr Asp Lys Asn Ile Ser Pro Arg Glu Asn Ile Leu Val 
         275                280                285
Ser Leu Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ser Phe 
     290                295                300
Pro Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr 
 305                310                315                320
Thr Phe Phe Ile Asp Cys Met Ala Ala Leu Gly Leu Ala Tyr Asp Arg 
                 325                330                335
Lys Lys Val Ser Lys Ala Ala Ile Leu Ala Arg Ile Lys Arg Thr Gly 
             340                345                350
Asp Gly Asn Tyr Lys Ser Gly 
         355



<210> 6988
<211> 448
<212> DNA
<213> Rattus norvegicus
<308> AI175935
<400> 6988

gaaagaaga  gacattgca  tgactccgt  acatttatt  aggaggtag  ggaggacgg  60
agaggggtg  caggagatt  acctacatg  agagggtca  ggggtctga  gggctgtgc  120
ggaatgcag  gactgtctc  ctaggcaaa  aggagaggg  gcgtctgta  gtacctggt  180
caaatcctg  aataaaacc  accttcacg  atgggtaca  tggaatact  cctgcggca  240
tcatacgtg  ttctaaact  ttctatata  agtatatgg  cactttttt  taaatgtac  300
gcttgggtg  ggggggaga  ctttcttct  ataagcaca  cattaaaca  aaaaccaac  360
tgggccagc  acattacaa  caaagacca  gggaaagca  gaccatcag  cagcccagc  420
cccaacttc  tccccacca  cagtctta  448



<210> 6989
<211> 586
<212> DNA
<213> Rattus norvegicus
<308> AI176021
<400> 6989

cctgtcacc  ttgccaggg  tgggaacgc  ggagagttg  tctctcccc  tctcctgcc  60
ccaacacgg  ggcggcggc  gcggcacgt  cagggaccc  ggccggtgt  aagcctccc  120
tccgccgcc  ccgcacccc  cctggcccg  gctccggag  ccgccggag  aggcagccg  180
tgcgaggat  atccgtctt  tccccattc  gctgcttcg  ctgccaggc  tctggctgc  240
gaggagaag  aggcccagt  gctgcaacc  tccagcagc  gccgcagca  ccattaccc  300
gctgcggtc  agggccaag  ggcagcaga  cgaggggca  cagcgaccg  caagtccag  360
gccatttcc  tcctgcaga  gaagcctcg  caccagcag  ttctgccat  tctctcctc  420
tttttcttc  gccacaggc  cccagacat  acagccatc  tcaaagaga  cgttagcag  480
aacaaaagg  gatatcaag  ggatggatt  gacttagac  tgacctata  ttatccaaa  540
attattgct  tgggatttc  tgcagaaag  cttgaangt  tataca  586



<210> 6990
<211> 403
<212> PRT
<213> Rattus norvegicus
<308> NP_032986
<400> 6990

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
  1               5                  10                  15
Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
             20                  25                  30
Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
         35                  40                  45
Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
     50                  55                  60
Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
 65                  70                  75                  80
Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                 85                  90                  95
Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
             100                105                110
Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
         115                120                125
Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
     130                135                140
Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
 145                150                155                160
Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                 165                170                175
Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
             180                185                190
Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
         195                200                205
Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
     210                215                220
Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
 225                230                235                240
Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                 245                250                255
Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
             260                265                270
Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
         275                280                285
Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
     290                295                300
Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
 305                310                315                320
Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                 325                330                335
Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
             340                345                350
Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
         355                360                365
Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
     370                375                380
Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Ser Gln Ile 
 385                390                395                400
Thr Lys Val 
                 405



<210> 6991
<211> 804
<212> DNA
<213> Homo sapiens
<308> BI823499
<400> 6991

ccgacgagc  ctgcactaa  gcaggatcc  gctgccgaa  gtcctcgcc  gcaggatga  60
gttaaagga  gtagatcgt  cagccatgc  ggcatggag  cctgcccag  atcacccca  120
ttacctagc  acaggaaca  ctgctcagc  attggatgc  acatttagt  cgaatgctt  180
ccttgagat  tttgaatta  acctctctg  tccatcctt  gatatgaaa  cttgtgcca  240
attctcctc  tctcacagg  accacaagt  gatttgggg  ccttataaa  tggattcca  300
aggagatgt  tctggagtt  tgattgcag  tggtgaaaa  ggaaatatt  ttctctatg  360
tccttctaa  attatagct  gagacaagg  agttgtgat  gcccagaat  acaagcata  420
tggcccagt  agagccttg  atgtgaaca  tttccaggt  aagctgtac  tcacaaaaa  480
agtagagga  ccgtcaaat  cagaggcta  cagttcaac  tctgtaaca  cagatgtta  540
tgacaatga  cctgatcat  atagatatt  tgacgacca  tgactctga  ccagagaat  600
aaccttttg  tgaagatca  catacacaa  ttacaaaag  ctgaatttt  ttttatcaa  660
agggataaa  caccatgaa  atcaacttg  ataacctga  aatggacct  ttttttttt  720
aatggcaat  ggacatggt  tcagattac  agttatcgg  acaattctc  tttcctgac  780
aaatcttgt  ttaccctat  catc  804



<210> 6992
<211> 587
<212> DNA
<213> Rattus norvegicus
<308> AI176052
<400> 6992

tctgactaa  tgaacaaag  ttagatgat  accagttgc  ctctctctt  ttttttttt  60
ttttttttt  tttttttgg  tcttttttt  ttttggttc  ttttttttt  ggagctggg  120
accgaaccc  gggccttgt  cttcctagg  aagcgcttt  ccactgagc  aaatcccca  180
ccccaccag  tgctctctt  attgtgctc  gagtttgtt  gtttcaaca  gtctgacgt  240
ttgaattgc  catccatgg  agacaacta  ataaacaca  ggtcagcct  agtttctga  300
tcattaggc  gagccatta  gactaaatc  taattttca  agaagtctt  ggaaaagag  360
ttcgaaata  agaggccag  ggaggagtg  aggaggccc  gcttcatcc  gccaagtgc  420
ttcctcagg  agtaacaga  gctttttgg  tggtttctg  aactttcat  tgcaggaag  480
agtattcgt  gggccaaat  ttgttggtt  ctgttcccg  aaatgtttc  aacacccct  540
ttttctggg  atactgcag  accggcttt  tctgggctt  atacgcc  587



<210> 6993
<211> 226
<212> PRT
<213> Rattus norvegicus
<308> P29411
<400> 6993

Gly Ala Ser Gly Arg Leu Leu Arg Ala Val Ile Met Gly Ala Pro Gly 
  1               5                  10                  15
Ser Gly Lys Gly Thr Gly Ser Ser Arg Ile Thr Lys His Phe Glu Leu 
             20                  25                  30
Lys His Leu Ser Ser Gly Asp Leu Leu Arg Gln Asn Met Leu Gln Gly 
         35                  40                  45
Thr Glu Ile Ala Val Leu Ala Lys Ser Phe Ile Asp Gln Gly Lys Leu 
     50                  55                  60
Ile Pro Asp Asp Asp Met Thr Arg Leu Ala Leu His Glu Leu Lys Asn 
 65                  70                  75                  80
Leu Thr Gln Cys Ser Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Pro 
                 85                  90                  95
Gln Ala Glu Ala Leu Asp Arg Val Tyr Gln Ile Asp Thr Val Ile Asn 
             100                105                110
Leu Asn Val Pro Phe Glu Val Ile Lys Leu Arg Leu Thr Ala Arg Trp 
         115                120                125
Ile His Pro Ala Ser Gly Arg Val Tyr Asn Ile Glu Phe Asn Pro Pro 
     130                135                140
Lys Thr Val Gly Ile Asp Asp Leu Thr Gly Glu Pro Leu Ile Gln Arg 
 145                150                155                160
Glu Asp Asp Lys Pro Glu Thr Val Ile Lys Arg Leu Lys Ala Tyr Glu 
                 165                170                175
Ala Gln Thr Glu Pro Val Leu Gln Tyr Tyr Gln Lys Lys Gly Val Leu 
             180                185                190
Glu Thr Phe Ser Gly Thr Glu Thr Asn Lys Ile Arg Pro His Val Tyr 
         195                200                205
Ser Phe Leu Gln Met Lys Val Pro Glu Thr Ile Gln Lys Ala Ser Val 
     210                215                220
Thr Pro 
 225



<210> 6994
<211> 684
<212> DNA
<213> Homo sapiens
<308> AB021870
<400> 6994

atgggggcg  cggggcggc  gctgcgagc  gtgatcatg  gggccccgg  ctcgggcaa  60
ggcaccgtg  cgtcccgca  cactacaca  ttcgagctg  agcacctct  ccgcgggga  120
ctgctccgg  acaacatgc  gcggggcac  gaaattggc  tgttagccc  ggctttcat  180
gaccaaggg  aactcatcc  agattatgt  acgactcgg  tggcccttc  tgagctgaa  240
aacctcacc  agtatagct  gctgttgga  ggttttcca  ggacacttc  acaggcaga  300
gccctagat  gagcttatc  gatcgacac  gtgattaac  tgaatgtgc  ctttgaggt  360
attaaacaa  gccttactg  tcgctggat  catcccgcc  gtggccgag  ctataacat  420
gaattcaac  ctcccaaaa  tgtgggcat  gatgacctg  ctggggagc  tctcattca  480
cgtgaggat  ataaaccag  gacggttat  aagagacta  aggcttatg  agaccaaac  540
aagccagtc  tggaatatt  ccagaaaaa  ggggtgttg  aaacattct  cggaacaga  600
accaacaag  tttggccct  tgtatatgc  ttcctacaa  ctaaagttc  acaaagaag  660
cagaaagct  cagttactc  atga  684



<210> 6995
<211> 226
<212> PRT
<213> Homo sapiens
<308> Q9UIJ7
<400> 6995

Gly Ala Ser Gly Arg Leu Leu Arg Ala Val Ile Met Gly Ala Pro Gly 
  1               5                  10                  15
Ser Gly Lys Gly Thr Val Ser Ser Arg Ile Thr Thr His Phe Glu Leu 
             20                  25                  30
Lys His Leu Ser Arg Gly Asp Leu Leu Arg Asp Asn Met Leu Arg Gly 
         35                  40                  45
Thr Glu Ile Gly Val Leu Ala Gln Ala Phe Ile Asp Gln Gly Lys Leu 
     50                  55                  60
Ile Pro Asp Tyr Val Thr Thr Arg Leu Ala Leu His Glu Leu Lys Asn 
 65                  70                  75                  80
Leu Thr Gln Tyr Ser Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Pro 
                 85                  90                  95
Gln Ala Glu Ala Leu Asp Arg Ala Tyr Gln Ile Asp Thr Val Ile Asn 
             100                105                110
Leu Asn Val Pro Phe Glu Val Ile Lys Gln Arg Leu Thr Ala Arg Trp 
         115                120                125
Ile His Pro Ala Ser Gly Arg Val Tyr Asn Ile Glu Phe Asn Pro Pro 
     130                135                140
Lys Thr Val Gly Ile Asp Asp Leu Thr Gly Glu Pro Leu Ile Gln Arg 
 145                150                155                160
Glu Asp Asp Lys Pro Glu Thr Val Ile Lys Arg Leu Lys Ala Tyr Glu 
                 165                170                175
Asp Gln Thr Lys Pro Val Leu Glu Tyr Tyr Gln Lys Lys Gly Val Leu 
             180                185                190
Glu Thr Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val Tyr 
         195                200                205
Ala Phe Leu Gln Thr Lys Val Pro Gln Arg Ser Gln Lys Ala Ser Val 
     210                215                220
Thr Pro 
 225



<210> 6996
<211> 469
<212> DNA
<213> Rattus norvegicus
<308> AI176170
<400> 6996

gaaaaaagc  agcataaag  acttttatt  caataataa  acttgaacc  catatgtag  60
gcaaaggca  gggacaaaa  ctttctctc  ccaaatcac  acacgggac  gcagagggt  120
aaaaggaac  gaaggagga  aagccagga  gctgggatc  gcagagagc  aagcatcaa  180
acctgggag  tgctgaagc  gtgatgacc  gcatcattt  cttagagaa  actcaagga  240
ttgttgtgg  ggctgggca  ccactgggt  gtgagtcta  aaacagcac  ttcagttta  300
actttccac  gaagttcta  aatttagta  gtggagcgt  atagttaca  gattacaaa  360
gtccagaaa  tccattaga  aaaccatag  atgaaaaac  aattaagcc  ggtcacaaa  420
aaggcttca  aggtccctg  cgacccagg  acagatatt  tagtgttca  469



<210> 6997
<211> 107
<212> PRT
<213> Rattus norvegicus
<308> Q62658
<400> 6997

Gly Val Gln Val Glu Thr Ile Ser Ser Gly Asp Gly Arg Thr Phe Pro 
  1               5                  10                  15
Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
             20                  25                  30
Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
         35                  40                  45
Thr Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
     50                  55                  60
Gln Met Ser Val Gly Gln Arg Ala Lys Leu Ile Ile Ser Pro Asp Tyr 
 65                  70                  75                  80
Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                 85                  90                  95
Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
             100                105



<210> 6999
<211> 1249
<212> PRT
<213> Rattus norvegicus
<308> Q64560
<400> 6999

Met Ala Thr Ala Ala Thr Glu Glu Pro Phe Pro Phe His Gly Leu Leu 
  1               5                  10                  15
Pro Lys Lys Glu Thr Gly Ala Ser Ser Phe Leu Cys Arg Tyr Pro Glu 
             20                  25                  30
Tyr Asp Gly Arg Gly Val Leu Ile Ala Val Leu Asp Thr Gly Val Asp 
         35                  40                  45
Pro Gly Ala Pro Gly Met Gln Val Thr Thr Asp Gly Lys Pro Lys Ile 
     50                  55                  60
Ile Asp Ile Ile Asp Thr Thr Gly Ser Gly Asp Val Asn Thr Ala Thr 
 65                  70                  75                  80
Glu Val Glu Pro Lys Asp Gly Glu Ile Thr Gly Leu Ser Gly Arg Val 
                 85                  90                  95
Leu Lys Ile Pro Ala Asn Trp Thr Asn Pro Ser Gly Lys Tyr His Ile 
             100                105                110
Gly Ile Lys Asn Gly Tyr Asp Phe Tyr Pro Lys Ala Leu Lys Glu Arg 
         115                120                125
Ile Gln Lys Glu Arg Lys Glu Lys Ile Trp Asp Pro Ile His Arg Val 
     130                135                140
Ala Leu Ala Glu Ala Cys Arg Lys Gln Glu Glu Phe Asp Ile Ala Asn 
 145                150                155                160
Asn Gly Ser Ser Gln Ala Asn Lys Leu Ile Lys Glu Glu Leu Gln Ser 
                 165                170                175
Gln Val Glu Leu Leu Asn Ser Phe Glu Lys Lys Tyr Ser Asp Pro Gly 
             180                185                190
Pro Val Tyr Asp Cys Leu Val Trp His Asp Gly Glu Thr Trp Arg Ala 
         195                200                205
Cys Val Asp Ser Asn Glu Asn Gly Asp Leu Gly Lys Ser Thr Val Leu 
     210                215                220
Arg Asn Tyr Lys Glu Ala Gln Glu Tyr Gly Ser Phe Gly Thr Ala Glu 
 225                230                235                240
Met Leu Asn Tyr Ser Val Asn Ile Tyr Asp Asp Gly Asn Leu Leu Ser 
                 245                250                255
Ile Val Thr Ser Gly Gly Ala His Gly Thr His Val Ala Ser Ile Ala 
             260                265                270
Ala Gly His Phe Pro Glu Glu Pro Glu Arg Asn Gly Val Ala Pro Gly 
         275                280                285
Ala Gln Ile Leu Ser Ile Lys Ile Gly Asp Thr Arg Leu Ser Thr Met 
     290                295                300
Glu Thr Gly Thr Gly Leu Ile Arg Ala Met Ile Glu Val Ile Asn His 
 305                310                315                320
Lys Cys Asp Leu Val Asn Tyr Ser Tyr Gly Glu Ala Thr His Trp Pro 
                 325                330                335
Asn Ser Gly Arg Ile Cys Glu Val Ile Asn Glu Ala Val Trp Lys His 
             340                345                350
Asn Thr Ile Tyr Val Ser Ser Ala Gly Asn Asn Gly Pro Cys Leu Ser 
         355                360                365
Thr Val Gly Cys Pro Gly Gly Thr Thr Ser Ser Val Ile Gly Val Gly 
     370                375                380
Ala Tyr Val Ser Pro Asp Met Met Val Ala Glu Tyr Ser Leu Arg Glu 
 385                390                395                400
Lys Leu Pro Ala Asn Gln Tyr Thr Trp Ser Ser Arg Gly Pro Ser Ala 
                 405                410                415
Asp Gly Ala Leu Gly Val Ser Ile Ser Ala Pro Gly Gly Ala Ile Ala 
             420                425                430
Ser Val Pro Asn Trp Thr Leu Arg Gly Thr Gln Leu Met Asn Gly Thr 
         435                440                445
Ser Met Ser Ser Pro Asn Ala Cys Gly Gly Ile Ala Leu Val Leu Ser 
     450                455                460
Gly Leu Lys Ala Asn Asn Val Asp Tyr Thr Val His Ser Val Arg Arg 
 465                470                475                480
Ala Leu Glu Asn Thr Ala Ile Lys Ala Asp Asn Ile Glu Val Phe Ala 
                 485                490                495
Gln Gly His Gly Ile Ile Gln Val Asp Lys Ala Tyr Asp Tyr Leu Ile 
             500                505                510
Gln Asn Thr Ser Phe Ala Asn Arg Leu Gly Phe Thr Val Thr Val Gly 
         515                520                525
Asn Asn Arg Gly Ile Tyr Leu Arg Asp Pro Val Gln Val Ala Ala Pro 
     530                535                540
Ser Asp His Gly Val Gly Ile Glu Pro Val Phe Pro Glu Asn Thr Glu 
 545                550                555                560
Asn Ser Glu Lys Ile Ser Phe Gln Leu His Leu Ala Leu Thr Ser Asn 
                 565                570                575
Ser Ser Trp Val Gln Cys Pro Ser His Leu Glu Leu Met Asn Gln Cys 
             580                585                590
Arg His Ile Asn Ile Arg Val Asp Pro Arg Gly Leu Arg Glu Gly Leu 
         595                600                605
His Tyr Thr Glu Val Cys Gly Tyr Asp Ile Ala Ser Pro Asn Ala Gly 
     610                615                620
Pro Leu Phe Arg Val Pro Ile Thr Ala Val Ile Ala Ala Lys Val Asn 
 625                630                635                640
Glu Ser Ser His Tyr Asp Leu Ala Phe Thr Asp Val His Phe Lys Pro 
                 645                650                655
Gly Gln Ile Arg Arg His Phe Val Glu Val Pro Glu Gly Ala Thr Trp 
             660                665                670
Ala Glu Val Thr Val Cys Ser Cys Ser Ser Glu Val Ser Ala Lys Phe 
         675                680                685
Val Leu His Ala Val Gln Leu Val Lys Gln Arg Ala Tyr Arg Ser His 
     690                695                700
Glu Phe Tyr Lys Phe Cys Ser Leu Pro Glu Lys Gly Thr Leu Ile Glu 
 705                710                715                720
Ala Phe Pro Val Leu Gly Gly Lys Ala Ile Glu Phe Cys Ile Ala Arg 
                 725                730                735
Trp Trp Ala Ser Leu Ser Asp Val Asn Ile Asp Tyr Thr Ile Ser Phe 
             740                745                750
His Gly Ile Val Cys Thr Ala Pro Gln Leu Asn Ile His Ala Ser Glu 
         755                760                765
Gly Ile Asn Arg Phe Asp Val Gln Ser Ser Leu Lys Tyr Glu Asp Leu 
     770                775                780
Ala Pro Cys Ile Thr Leu Lys Ser Trp Val Gln Thr Leu Arg Pro Val 
 785                790                795                800
Asn Ala Lys Thr Arg Pro Leu Gly Ser Arg Asp Val Leu Pro Asn Asn 
                 805                810                815
Arg Gln Leu Tyr Glu Met Val Leu Thr Tyr Ser Phe His Gln Pro Lys 
             820                825                830
Ser Gly Glu Val Thr Pro Ser Cys Pro Leu Leu Cys Glu Leu Leu Tyr 
         835                840                845
Glu Ser Glu Phe Asp Ser Gln Leu Trp Ile Ile Phe Asp Gln Asn Lys 
     850                855                860
Arg Gln Met Gly Ser Gly Asp Ala Tyr Pro His Gln Tyr Ser Leu Lys 
 865                870                875                880
Leu Glu Lys Gly Asp Tyr Thr Ile Arg Leu Gln Ile Arg His Glu Gln 
                 885                890                895
Ile Ser Asp Leu Asp Arg Leu Lys Asp Leu Pro Phe Ile Val Ser His 
             900                905                910
Arg Leu Ser Asn Thr Leu Ser Leu Asp Ile His Glu Asn His Ser Leu 
         915                920                925
Ala Leu Leu Gly Lys Lys Lys Ser Ser Ser Leu Thr Leu Pro Pro Lys 
     930                935                940
Tyr Asn Gln Pro Phe Phe Val Thr Ser Leu Pro Asp Asp Lys Ile Pro 
 945                950                955                960
Lys Gly Ala Gly Pro Gly Cys Tyr Leu Ala Gly Ser Leu Thr Leu Ser 
                 965                970                975
Lys Thr Glu Leu Gly Lys Lys Ala Asp Val Ile Pro Val His Tyr Tyr 
             980                985                990
Leu Ile Pro Pro Pro Thr Lys Thr Lys Asn Gly Ser Lys Asp Lys Glu 
         995                1000                1005
Lys Asp Ser Glu Lys Glu Lys Asp Leu Lys Glu Glu Phe Thr Glu Ala 
     1010                1015                1020
Leu Arg Asp Leu Lys Ile Gln Trp Met Thr Lys Leu Asp Ser Thr Asp 
 1025                1030                1035                1040
Ile Tyr Asn Glu Leu Lys Glu Thr Tyr Pro Ala Tyr Leu Pro Leu Tyr 
                 1045                1050                1055
Val Ala Arg Leu His Gln Leu Asp Ala Glu Lys Glu Arg Met Lys Arg 
             1060                1065                1070
Leu Asn Glu Ile Val Asp Ala Ala Asn Ala Val Ile Ser His Ile Asp 
         1075                1080                1085
Gln Thr Ala Leu Ala Val Tyr Ile Ala Met Lys Thr Asp Pro Arg Pro 
     1090                1095                1100
Asp Ala Ala Thr Ile Lys Asn Asp Met Asp Lys Gln Lys Ser Thr Leu 
 1105                1110                1115                1120
Val Asp Ala Leu Cys Arg Lys Gly Cys Ala Leu Ala Asp His Leu Leu 
                 1125                1130                1135
His Ala Gln Pro His Asp Gly Ala Ala Ala Gly Asp Ala Glu Ala Lys 
             1140                1145                1150
Glu Glu Glu Gly Glu Ser Thr Leu Glu Ser Leu Ser Glu Thr Tyr Trp 
         1155                1160                1165
Glu Thr Thr Lys Trp Thr Asp Leu Phe Asp Thr Lys Val Leu Thr Phe 
     1170                1175                1180
Ala Tyr Lys His Ala Leu Val Asn Lys Met Tyr Gly Arg Gly Leu Lys 
 1185                1190                1195                1200
Phe Ala Thr Lys Leu Val Glu Glu Lys Pro Thr Lys Glu Asn Trp Lys 
                 1205                1210                1215
Asn Cys Ile Gln Leu Met Lys Leu Leu Gly Trp Thr His Cys Ala Ser 
             1220                1225                1230
Phe Thr Glu Asn Trp Leu Pro Ile Met Tyr Pro Pro Asp Tyr Cys Val 
         1235                1240                1245
Phe 
     1250



<210> 7001
<211> 1249
<212> PRT
<213> Homo sapiens
<308> P29144
<400> 7001

Met Ala Thr Ala Ala Thr Glu Glu Pro Phe Pro Phe His Gly Leu Leu 
  1               5                  10                  15
Pro Lys Lys Glu Thr Gly Ala Ala Ser Phe Leu Cys Arg Tyr Pro Glu 
             20                  25                  30
Tyr Asp Gly Arg Gly Val Leu Ile Ala Val Leu Asp Thr Gly Val Asp 
         35                  40                  45
Pro Gly Ala Pro Gly Met Gln Val Thr Thr Asp Gly Lys Pro Lys Ile 
     50                  55                  60
Val Asp Ile Ile Asp Thr Thr Gly Ser Gly Asp Val Asn Thr Ala Thr 
 65                  70                  75                  80
Glu Val Glu Pro Lys Asp Gly Glu Ile Val Gly Leu Ser Gly Arg Val 
                 85                  90                  95
Leu Lys Ile Pro Ala Ser Trp Thr Asn Pro Ser Gly Lys Tyr His Ile 
             100                105                110
Gly Ile Lys Asn Gly Tyr Asp Phe Tyr Pro Lys Ala Leu Lys Glu Arg 
         115                120                125
Ile Gln Lys Glu Arg Lys Glu Lys Ile Trp Asp Pro Val His Arg Val 
     130                135                140
Ala Leu Ala Glu Ala Cys Arg Lys Gln Glu Glu Phe Asp Val Ala Asn 
 145                150                155                160
Asn Gly Ser Ser Gln Ala Asn Lys Leu Ile Lys Glu Glu Leu Gln Ser 
                 165                170                175
Gln Val Glu Leu Leu Asn Ser Phe Glu Lys Lys Tyr Ser Asp Pro Gly 
             180                185                190
Pro Val Tyr Asp Cys Leu Val Trp His Asp Gly Glu Val Trp Arg Ala 
         195                200                205
Cys Ile Asp Ser Asn Glu Asp Gly Asp Leu Ser Lys Ser Thr Val Leu 
     210                215                220
Arg Asn Tyr Lys Glu Ala Gln Glu Tyr Gly Ser Phe Gly Thr Ala Glu 
 225                230                235                240
Met Leu Asn Tyr Ser Val Asn Ile Tyr Asp Asp Arg Asn Leu Leu Ser 
                 245                250                255
Ile Val Thr Ser Gly Gly Ala His Gly Thr His Val Ala Ser Ile Ala 
             260                265                270
Ala Gly His Phe Pro Glu Glu Pro Glu Arg Asn Gly Val Ala Pro Gly 
         275                280                285
Ala Gln Ile Leu Ser Ile Lys Ile Gly Asp Thr Arg Leu Ser Thr Met 
     290                295                300
Glu Thr Gly Thr Gly Leu Ile Arg Ala Met Ile Glu Val Ile Asn His 
 305                310                315                320
Lys Cys Asp Leu Val Asn Tyr Ser Tyr Gly Glu Ala Thr His Trp Pro 
                 325                330                335
Asn Ser Gly Arg Ile Cys Glu Val Ile Asn Glu Ala Val Trp Lys His 
             340                345                350
Asn Ile Ile Tyr Val Ser Ser Ala Gly Asn Asn Gly Pro Cys Leu Ser 
         355                360                365
Thr Val Gly Cys Pro Gly Gly Thr Thr Ser Ser Val Ile Gly Val Gly 
     370                375                380
Ala Tyr Val Ser Pro Asp Met Met Val Ala Glu Tyr Ser Leu Arg Glu 
 385                390                395                400
Lys Leu Pro Ala Asn Gln Tyr Thr Trp Ser Ser Arg Gly Pro Ser Ala 
                 405                410                415
Asp Gly Ala Leu Gly Val Ser Ile Ser Ala Pro Gly Gly Ala Ile Ala 
             420                425                430
Ser Val Pro Asn Trp Thr Leu Arg Gly Thr Gln Leu Met Asn Gly Thr 
         435                440                445
Ser Met Ser Ser Pro Asn Ala Cys Gly Gly Ile Ala Leu Ile Leu Ser 
     450                455                460
Gly Leu Lys Ala Asn Asn Ile Asp Tyr Thr Val His Ser Val Arg Arg 
 465                470                475                480
Ala Leu Glu Asn Thr Ala Val Lys Ala Asp Asn Ile Glu Val Phe Ala 
                 485                490                495
Gln Gly His Gly Ile Ile Gln Val Asp Lys Ala Tyr Asp Tyr Leu Val 
             500                505                510
Gln Asn Thr Ser Phe Ala Asn Lys Leu Gly Phe Thr Val Thr Val Gly 
         515                520                525
Asn Asn Arg Gly Ile Tyr Leu Arg Asp Pro Val Gln Val Ala Ala Pro 
     530                535                540
Ser Asp His Gly Val Gly Ile Glu Pro Val Phe Pro Glu Asn Thr Glu 
 545                550                555                560
Asn Ser Glu Lys Ile Ser Leu Gln Leu His Leu Ala Leu Thr Ser Asn 
                 565                570                575
Ser Ser Trp Val Gln Cys Pro Ser His Leu Glu Leu Met Asn Gln Cys 
             580                585                590
Arg His Ile Asn Ile Arg Val Asp Pro Arg Gly Leu Arg Glu Gly Leu 
         595                600                605
His Tyr Thr Glu Val Cys Gly Tyr Asp Ile Ala Ser Pro Asn Ala Gly 
     610                615                620
Pro Leu Phe Arg Val Pro Ile Thr Ala Val Ile Ala Ala Lys Val Asn 
 625                630                635                640
Glu Ser Ser His Tyr Asp Leu Ala Phe Thr Asp Val His Phe Lys Pro 
                 645                650                655
Gly Gln Ile Arg Arg His Phe Ile Glu Val Pro Glu Gly Ala Thr Trp 
             660                665                670
Ala Glu Val Thr Val Cys Ser Cys Ser Ser Glu Val Ser Ala Lys Phe 
         675                680                685
Val Leu His Ala Val Gln Leu Val Lys Gln Arg Ala Tyr Arg Ser His 
     690                695                700
Glu Phe Tyr Lys Phe Cys Ser Leu Pro Glu Lys Gly Thr Leu Thr Glu 
 705                710                715                720
Ala Phe Pro Val Leu Gly Gly Lys Ala Ile Glu Phe Cys Ile Ala Arg 
                 725                730                735
Trp Trp Ala Ser Leu Ser Asp Val Asn Ile Asp Tyr Thr Ile Ser Phe 
             740                745                750
His Gly Ile Val Cys Thr Ala Pro Gln Leu Asn Ile His Ala Ser Glu 
         755                760                765
Gly Ile Asn Arg Phe Asp Val Gln Ser Ser Leu Lys Tyr Glu Asp Leu 
     770                775                780
Ala Pro Cys Ile Thr Leu Lys Asn Trp Val Gln Thr Leu Arg Pro Val 
 785                790                795                800
Ser Ala Lys Thr Lys Pro Leu Gly Ser Arg Asp Val Leu Pro Asn Asn 
                 805                810                815
Arg Gln Leu Tyr Glu Met Val Leu Thr Tyr Asn Phe His Gln Pro Lys 
             820                825                830
Ser Gly Glu Val Thr Pro Ser Cys Pro Leu Leu Cys Glu Leu Leu Tyr 
         835                840                845
Glu Ser Glu Phe Asp Ser Gln Leu Trp Ile Ile Phe Asp Gln Asn Lys 
     850                855                860
Arg Gln Met Gly Ser Gly Asp Ala Tyr Pro His Gln Tyr Ser Leu Lys 
 865                870                875                880
Leu Glu Lys Gly Asp Tyr Thr Ile Arg Leu Gln Ile Arg His Glu Gln 
                 885                890                895
Ile Ser Asp Leu Glu Arg Leu Lys Asp Leu Pro Phe Ile Val Ser His 
             900                905                910
Arg Leu Ser Asn Thr Leu Ser Leu Asp Ile His Glu Asn His Ser Phe 
         915                920                925
Ala Leu Leu Gly Lys Lys Lys Ser Ser Asn Leu Thr Leu Pro Pro Lys 
     930                935                940
Tyr Asn Gln Pro Phe Phe Val Thr Ser Leu Pro Asp Asp Lys Ile Pro 
 945                950                955                960
Lys Gly Ala Gly Pro Gly Cys Tyr Leu Ala Gly Ser Leu Thr Leu Ser 
                 965                970                975
Lys Thr Glu Leu Gly Lys Lys Ala Asp Val Ile Pro Val His Tyr Tyr 
             980                985                990
Leu Ile Pro Pro Pro Thr Lys Thr Lys Asn Gly Ser Lys Asp Lys Glu 
         995                1000                1005
Lys Asp Ser Glu Lys Glu Lys Asp Leu Lys Glu Glu Phe Thr Glu Ala 
     1010                1015                1020
Leu Arg Asp Leu Lys Ile Gln Trp Met Thr Lys Leu Asp Ser Ser Asp 
 1025                1030                1035                1040
Ile Tyr Asn Glu Leu Lys Glu Thr Tyr Pro Asn Tyr Leu Pro Leu Tyr 
                 1045                1050                1055
Val Ala Arg Leu His Gln Leu Asp Ala Glu Lys Glu Arg Met Lys Arg 
             1060                1065                1070
Leu Asn Glu Ile Val Asp Ala Ala Asn Ala Val Ile Ser His Ile Asp 
         1075                1080                1085
Gln Thr Ala Leu Ala Val Tyr Ile Ala Met Lys Thr Asp Pro Arg Pro 
     1090                1095                1100
Asp Ala Ala Thr Ile Lys Asn Asp Met Asp Lys Gln Lys Ser Thr Leu 
 1105                1110                1115                1120
Val Asp Ala Leu Cys Arg Lys Gly Cys Ala Leu Ala Asp His Leu Leu 
                 1125                1130                1135
His Thr Gln Ala Gln Asp Gly Ala Ile Ser Thr Asp Ala Glu Gly Lys 
             1140                1145                1150
Glu Glu Glu Gly Glu Ser Pro Leu Asp Ser Leu Ala Glu Thr Phe Trp 
         1155                1160                1165
Glu Thr Thr Lys Trp Thr Asp Leu Phe Asp Asn Lys Val Leu Thr Phe 
     1170                1175                1180
Ala Tyr Lys His Ala Leu Val Asn Lys Met Tyr Gly Arg Gly Leu Lys 
 1185                1190                1195                1200
Phe Ala Thr Lys Leu Val Glu Glu Lys Pro Thr Lys Glu Asn Trp Lys 
                 1205                1210                1215
Asn Cys Ile Gln Leu Met Lys Leu Leu Gly Trp Thr His Cys Ala Ser 
             1220                1225                1230
Phe Thr Glu Asn Trp Leu Pro Ile Met Tyr Pro Pro Asp Tyr Cys Val 
         1235                1240                1245
Phe 
     1250



<210> 7003
<211> 1249
<212> PRT
<213> Rattus norvegicus
<308> Q64560
<400> 7003

Met Ala Thr Ala Ala Thr Glu Glu Pro Phe Pro Phe His Gly Leu Leu 
  1               5                  10                  15
Pro Lys Lys Glu Thr Gly Ala Ser Ser Phe Leu Cys Arg Tyr Pro Glu 
             20                  25                  30
Tyr Asp Gly Arg Gly Val Leu Ile Ala Val Leu Asp Thr Gly Val Asp 
         35                  40                  45
Pro Gly Ala Pro Gly Met Gln Val Thr Thr Asp Gly Lys Pro Lys Ile 
     50                  55                  60
Ile Asp Ile Ile Asp Thr Thr Gly Ser Gly Asp Val Asn Thr Ala Thr 
 65                  70                  75                  80
Glu Val Glu Pro Lys Asp Gly Glu Ile Thr Gly Leu Ser Gly Arg Val 
                 85                  90                  95
Leu Lys Ile Pro Ala Asn Trp Thr Asn Pro Ser Gly Lys Tyr His Ile 
             100                105                110
Gly Ile Lys Asn Gly Tyr Asp Phe Tyr Pro Lys Ala Leu Lys Glu Arg 
         115                120                125
Ile Gln Lys Glu Arg Lys Glu Lys Ile Trp Asp Pro Ile His Arg Val 
     130                135                140
Ala Leu Ala Glu Ala Cys Arg Lys Gln Glu Glu Phe Asp Ile Ala Asn 
 145                150                155                160
Asn Gly Ser Ser Gln Ala Asn Lys Leu Ile Lys Glu Glu Leu Gln Ser 
                 165                170                175
Gln Val Glu Leu Leu Asn Ser Phe Glu Lys Lys Tyr Ser Asp Pro Gly 
             180                185                190
Pro Val Tyr Asp Cys Leu Val Trp His Asp Gly Glu Thr Trp Arg Ala 
         195                200                205
Cys Val Asp Ser Asn Glu Asn Gly Asp Leu Gly Lys Ser Thr Val Leu 
     210                215                220
Arg Asn Tyr Lys Glu Ala Gln Glu Tyr Gly Ser Phe Gly Thr Ala Glu 
 225                230                235                240
Met Leu Asn Tyr Ser Val Asn Ile Tyr Asp Asp Gly Asn Leu Leu Ser 
                 245                250                255
Ile Val Thr Ser Gly Gly Ala His Gly Thr His Val Ala Ser Ile Ala 
             260                265                270
Ala Gly His Phe Pro Glu Glu Pro Glu Arg Asn Gly Val Ala Pro Gly 
         275                280                285
Ala Gln Ile Leu Ser Ile Lys Ile Gly Asp Thr Arg Leu Ser Thr Met 
     290                295                300
Glu Thr Gly Thr Gly Leu Ile Arg Ala Met Ile Glu Val Ile Asn His 
 305                310                315                320
Lys Cys Asp Leu Val Asn Tyr Ser Tyr Gly Glu Ala Thr His Trp Pro 
                 325                330                335
Asn Ser Gly Arg Ile Cys Glu Val Ile Asn Glu Ala Val Trp Lys His 
             340                345                350
Asn Thr Ile Tyr Val Ser Ser Ala Gly Asn Asn Gly Pro Cys Leu Ser 
         355                360                365
Thr Val Gly Cys Pro Gly Gly Thr Thr Ser Ser Val Ile Gly Val Gly 
     370                375                380
Ala Tyr Val Ser Pro Asp Met Met Val Ala Glu Tyr Ser Leu Arg Glu 
 385                390                395                400
Lys Leu Pro Ala Asn Gln Tyr Thr Trp Ser Ser Arg Gly Pro Ser Ala 
                 405                410                415
Asp Gly Ala Leu Gly Val Ser Ile Ser Ala Pro Gly Gly Ala Ile Ala 
             420                425                430
Ser Val Pro Asn Trp Thr Leu Arg Gly Thr Gln Leu Met Asn Gly Thr 
         435                440                445
Ser Met Ser Ser Pro Asn Ala Cys Gly Gly Ile Ala Leu Val Leu Ser 
     450                455                460
Gly Leu Lys Ala Asn Asn Val Asp Tyr Thr Val His Ser Val Arg Arg 
 465                470                475                480
Ala Leu Glu Asn Thr Ala Ile Lys Ala Asp Asn Ile Glu Val Phe Ala 
                 485                490                495
Gln Gly His Gly Ile Ile Gln Val Asp Lys Ala Tyr Asp Tyr Leu Ile 
             500                505                510
Gln Asn Thr Ser Phe Ala Asn Arg Leu Gly Phe Thr Val Thr Val Gly 
         515                520                525
Asn Asn Arg Gly Ile Tyr Leu Arg Asp Pro Val Gln Val Ala Ala Pro 
     530                535                540
Ser Asp His Gly Val Gly Ile Glu Pro Val Phe Pro Glu Asn Thr Glu 
 545                550                555                560
Asn Ser Glu Lys Ile Ser Phe Gln Leu His Leu Ala Leu Thr Ser Asn 
                 565                570                575
Ser Ser Trp Val Gln Cys Pro Ser His Leu Glu Leu Met Asn Gln Cys 
             580                585                590
Arg His Ile Asn Ile Arg Val Asp Pro Arg Gly Leu Arg Glu Gly Leu 
         595                600                605
His Tyr Thr Glu Val Cys Gly Tyr Asp Ile Ala Ser Pro Asn Ala Gly 
     610                615                620
Pro Leu Phe Arg Val Pro Ile Thr Ala Val Ile Ala Ala Lys Val Asn 
 625                630                635                640
Glu Ser Ser His Tyr Asp Leu Ala Phe Thr Asp Val His Phe Lys Pro 
                 645                650                655
Gly Gln Ile Arg Arg His Phe Val Glu Val Pro Glu Gly Ala Thr Trp 
             660                665                670
Ala Glu Val Thr Val Cys Ser Cys Ser Ser Glu Val Ser Ala Lys Phe 
         675                680                685
Val Leu His Ala Val Gln Leu Val Lys Gln Arg Ala Tyr Arg Ser His 
     690                695                700
Glu Phe Tyr Lys Phe Cys Ser Leu Pro Glu Lys Gly Thr Leu Ile Glu 
 705                710                715                720
Ala Phe Pro Val Leu Gly Gly Lys Ala Ile Glu Phe Cys Ile Ala Arg 
                 725                730                735
Trp Trp Ala Ser Leu Ser Asp Val Asn Ile Asp Tyr Thr Ile Ser Phe 
             740                745                750
His Gly Ile Val Cys Thr Ala Pro Gln Leu Asn Ile His Ala Ser Glu 
         755                760                765
Gly Ile Asn Arg Phe Asp Val Gln Ser Ser Leu Lys Tyr Glu Asp Leu 
     770                775                780
Ala Pro Cys Ile Thr Leu Lys Ser Trp Val Gln Thr Leu Arg Pro Val 
 785                790                795                800
Asn Ala Lys Thr Arg Pro Leu Gly Ser Arg Asp Val Leu Pro Asn Asn 
                 805                810                815
Arg Gln Leu Tyr Glu Met Val Leu Thr Tyr Ser Phe His Gln Pro Lys 
             820                825                830
Ser Gly Glu Val Thr Pro Ser Cys Pro Leu Leu Cys Glu Leu Leu Tyr 
         835                840                845
Glu Ser Glu Phe Asp Ser Gln Leu Trp Ile Ile Phe Asp Gln Asn Lys 
     850                855                860
Arg Gln Met Gly Ser Gly Asp Ala Tyr Pro His Gln Tyr Ser Leu Lys 
 865                870                875                880
Leu Glu Lys Gly Asp Tyr Thr Ile Arg Leu Gln Ile Arg His Glu Gln 
                 885                890                895
Ile Ser Asp Leu Asp Arg Leu Lys Asp Leu Pro Phe Ile Val Ser His 
             900                905                910
Arg Leu Ser Asn Thr Leu Ser Leu Asp Ile His Glu Asn His Ser Leu 
         915                920                925
Ala Leu Leu Gly Lys Lys Lys Ser Ser Ser Leu Thr Leu Pro Pro Lys 
     930                935                940
Tyr Asn Gln Pro Phe Phe Val Thr Ser Leu Pro Asp Asp Lys Ile Pro 
 945                950                955                960
Lys Gly Ala Gly Pro Gly Cys Tyr Leu Ala Gly Ser Leu Thr Leu Ser 
                 965                970                975
Lys Thr Glu Leu Gly Lys Lys Ala Asp Val Ile Pro Val His Tyr Tyr 
             980                985                990
Leu Ile Pro Pro Pro Thr Lys Thr Lys Asn Gly Ser Lys Asp Lys Glu 
         995                1000                1005
Lys Asp Ser Glu Lys Glu Lys Asp Leu Lys Glu Glu Phe Thr Glu Ala 
     1010                1015                1020
Leu Arg Asp Leu Lys Ile Gln Trp Met Thr Lys Leu Asp Ser Thr Asp 
 1025                1030                1035                1040
Ile Tyr Asn Glu Leu Lys Glu Thr Tyr Pro Ala Tyr Leu Pro Leu Tyr 
                 1045                1050                1055
Val Ala Arg Leu His Gln Leu Asp Ala Glu Lys Glu Arg Met Lys Arg 
             1060                1065                1070
Leu Asn Glu Ile Val Asp Ala Ala Asn Ala Val Ile Ser His Ile Asp 
         1075                1080                1085
Gln Thr Ala Leu Ala Val Tyr Ile Ala Met Lys Thr Asp Pro Arg Pro 
     1090                1095                1100
Asp Ala Ala Thr Ile Lys Asn Asp Met Asp Lys Gln Lys Ser Thr Leu 
 1105                1110                1115                1120
Val Asp Ala Leu Cys Arg Lys Gly Cys Ala Leu Ala Asp His Leu Leu 
                 1125                1130                1135
His Ala Gln Pro His Asp Gly Ala Ala Ala Gly Asp Ala Glu Ala Lys 
             1140                1145                1150
Glu Glu Glu Gly Glu Ser Thr Leu Glu Ser Leu Ser Glu Thr Tyr Trp 
         1155                1160                1165
Glu Thr Thr Lys Trp Thr Asp Leu Phe Asp Thr Lys Val Leu Thr Phe 
     1170                1175                1180
Ala Tyr Lys His Ala Leu Val Asn Lys Met Tyr Gly Arg Gly Leu Lys 
 1185                1190                1195                1200
Phe Ala Thr Lys Leu Val Glu Glu Lys Pro Thr Lys Glu Asn Trp Lys 
                 1205                1210                1215
Asn Cys Ile Gln Leu Met Lys Leu Leu Gly Trp Thr His Cys Ala Ser 
             1220                1225                1230
Phe Thr Glu Asn Trp Leu Pro Ile Met Tyr Pro Pro Asp Tyr Cys Val 
         1235                1240                1245
Phe 
     1250



<210> 7005
<211> 1249
<212> PRT
<213> Homo sapiens
<308> P29144
<400> 7005

Met Ala Thr Ala Ala Thr Glu Glu Pro Phe Pro Phe His Gly Leu Leu 
  1               5                  10                  15
Pro Lys Lys Glu Thr Gly Ala Ala Ser Phe Leu Cys Arg Tyr Pro Glu 
             20                  25                  30
Tyr Asp Gly Arg Gly Val Leu Ile Ala Val Leu Asp Thr Gly Val Asp 
         35                  40                  45
Pro Gly Ala Pro Gly Met Gln Val Thr Thr Asp Gly Lys Pro Lys Ile 
     50                  55                  60
Val Asp Ile Ile Asp Thr Thr Gly Ser Gly Asp Val Asn Thr Ala Thr 
 65                  70                  75                  80
Glu Val Glu Pro Lys Asp Gly Glu Ile Val Gly Leu Ser Gly Arg Val 
                 85                  90                  95
Leu Lys Ile Pro Ala Ser Trp Thr Asn Pro Ser Gly Lys Tyr His Ile 
             100                105                110
Gly Ile Lys Asn Gly Tyr Asp Phe Tyr Pro Lys Ala Leu Lys Glu Arg 
         115                120                125
Ile Gln Lys Glu Arg Lys Glu Lys Ile Trp Asp Pro Val His Arg Val 
     130                135                140
Ala Leu Ala Glu Ala Cys Arg Lys Gln Glu Glu Phe Asp Val Ala Asn 
 145                150                155                160
Asn Gly Ser Ser Gln Ala Asn Lys Leu Ile Lys Glu Glu Leu Gln Ser 
                 165                170                175
Gln Val Glu Leu Leu Asn Ser Phe Glu Lys Lys Tyr Ser Asp Pro Gly 
             180                185                190
Pro Val Tyr Asp Cys Leu Val Trp His Asp Gly Glu Val Trp Arg Ala 
         195                200                205
Cys Ile Asp Ser Asn Glu Asp Gly Asp Leu Ser Lys Ser Thr Val Leu 
     210                215                220
Arg Asn Tyr Lys Glu Ala Gln Glu Tyr Gly Ser Phe Gly Thr Ala Glu 
 225                230                235                240
Met Leu Asn Tyr Ser Val Asn Ile Tyr Asp Asp Arg Asn Leu Leu Ser 
                 245                250                255
Ile Val Thr Ser Gly Gly Ala His Gly Thr His Val Ala Ser Ile Ala 
             260                265                270
Ala Gly His Phe Pro Glu Glu Pro Glu Arg Asn Gly Val Ala Pro Gly 
         275                280                285
Ala Gln Ile Leu Ser Ile Lys Ile Gly Asp Thr Arg Leu Ser Thr Met 
     290                295                300
Glu Thr Gly Thr Gly Leu Ile Arg Ala Met Ile Glu Val Ile Asn His 
 305                310                315                320
Lys Cys Asp Leu Val Asn Tyr Ser Tyr Gly Glu Ala Thr His Trp Pro 
                 325                330                335
Asn Ser Gly Arg Ile Cys Glu Val Ile Asn Glu Ala Val Trp Lys His 
             340                345                350
Asn Ile Ile Tyr Val Ser Ser Ala Gly Asn Asn Gly Pro Cys Leu Ser 
         355                360                365
Thr Val Gly Cys Pro Gly Gly Thr Thr Ser Ser Val Ile Gly Val Gly 
     370                375                380
Ala Tyr Val Ser Pro Asp Met Met Val Ala Glu Tyr Ser Leu Arg Glu 
 385                390                395                400
Lys Leu Pro Ala Asn Gln Tyr Thr Trp Ser Ser Arg Gly Pro Ser Ala 
                 405                410                415
Asp Gly Ala Leu Gly Val Ser Ile Ser Ala Pro Gly Gly Ala Ile Ala 
             420                425                430
Ser Val Pro Asn Trp Thr Leu Arg Gly Thr Gln Leu Met Asn Gly Thr 
         435                440                445
Ser Met Ser Ser Pro Asn Ala Cys Gly Gly Ile Ala Leu Ile Leu Ser 
     450                455                460
Gly Leu Lys Ala Asn Asn Ile Asp Tyr Thr Val His Ser Val Arg Arg 
 465                470                475                480
Ala Leu Glu Asn Thr Ala Val Lys Ala Asp Asn Ile Glu Val Phe Ala 
                 485                490                495
Gln Gly His Gly Ile Ile Gln Val Asp Lys Ala Tyr Asp Tyr Leu Val 
             500                505                510
Gln Asn Thr Ser Phe Ala Asn Lys Leu Gly Phe Thr Val Thr Val Gly 
         515                520                525
Asn Asn Arg Gly Ile Tyr Leu Arg Asp Pro Val Gln Val Ala Ala Pro 
     530                535                540
Ser Asp His Gly Val Gly Ile Glu Pro Val Phe Pro Glu Asn Thr Glu 
 545                550                555                560
Asn Ser Glu Lys Ile Ser Leu Gln Leu His Leu Ala Leu Thr Ser Asn 
                 565                570                575
Ser Ser Trp Val Gln Cys Pro Ser His Leu Glu Leu Met Asn Gln Cys 
             580                585                590
Arg His Ile Asn Ile Arg Val Asp Pro Arg Gly Leu Arg Glu Gly Leu 
         595                600                605
His Tyr Thr Glu Val Cys Gly Tyr Asp Ile Ala Ser Pro Asn Ala Gly 
     610                615                620
Pro Leu Phe Arg Val Pro Ile Thr Ala Val Ile Ala Ala Lys Val Asn 
 625                630                635                640
Glu Ser Ser His Tyr Asp Leu Ala Phe Thr Asp Val His Phe Lys Pro 
                 645                650                655
Gly Gln Ile Arg Arg His Phe Ile Glu Val Pro Glu Gly Ala Thr Trp 
             660                665                670
Ala Glu Val Thr Val Cys Ser Cys Ser Ser Glu Val Ser Ala Lys Phe 
         675                680                685
Val Leu His Ala Val Gln Leu Val Lys Gln Arg Ala Tyr Arg Ser His 
     690                695                700
Glu Phe Tyr Lys Phe Cys Ser Leu Pro Glu Lys Gly Thr Leu Thr Glu 
 705                710                715                720
Ala Phe Pro Val Leu Gly Gly Lys Ala Ile Glu Phe Cys Ile Ala Arg 
                 725                730                735
Trp Trp Ala Ser Leu Ser Asp Val Asn Ile Asp Tyr Thr Ile Ser Phe 
             740                745                750
His Gly Ile Val Cys Thr Ala Pro Gln Leu Asn Ile His Ala Ser Glu 
         755                760                765
Gly Ile Asn Arg Phe Asp Val Gln Ser Ser Leu Lys Tyr Glu Asp Leu 
     770                775                780
Ala Pro Cys Ile Thr Leu Lys Asn Trp Val Gln Thr Leu Arg Pro Val 
 785                790                795                800
Ser Ala Lys Thr Lys Pro Leu Gly Ser Arg Asp Val Leu Pro Asn Asn 
                 805                810                815
Arg Gln Leu Tyr Glu Met Val Leu Thr Tyr Asn Phe His Gln Pro Lys 
             820                825                830
Ser Gly Glu Val Thr Pro Ser Cys Pro Leu Leu Cys Glu Leu Leu Tyr 
         835                840                845
Glu Ser Glu Phe Asp Ser Gln Leu Trp Ile Ile Phe Asp Gln Asn Lys 
     850                855                860
Arg Gln Met Gly Ser Gly Asp Ala Tyr Pro His Gln Tyr Ser Leu Lys 
 865                870                875                880
Leu Glu Lys Gly Asp Tyr Thr Ile Arg Leu Gln Ile Arg His Glu Gln 
                 885                890                895
Ile Ser Asp Leu Glu Arg Leu Lys Asp Leu Pro Phe Ile Val Ser His 
             900                905                910
Arg Leu Ser Asn Thr Leu Ser Leu Asp Ile His Glu Asn His Ser Phe 
         915                920                925
Ala Leu Leu Gly Lys Lys Lys Ser Ser Asn Leu Thr Leu Pro Pro Lys 
     930                935                940
Tyr Asn Gln Pro Phe Phe Val Thr Ser Leu Pro Asp Asp Lys Ile Pro 
 945                950                955                960
Lys Gly Ala Gly Pro Gly Cys Tyr Leu Ala Gly Ser Leu Thr Leu Ser 
                 965                970                975
Lys Thr Glu Leu Gly Lys Lys Ala Asp Val Ile Pro Val His Tyr Tyr 
             980                985                990
Leu Ile Pro Pro Pro Thr Lys Thr Lys Asn Gly Ser Lys Asp Lys Glu 
         995                1000                1005
Lys Asp Ser Glu Lys Glu Lys Asp Leu Lys Glu Glu Phe Thr Glu Ala 
     1010                1015                1020
Leu Arg Asp Leu Lys Ile Gln Trp Met Thr Lys Leu Asp Ser Ser Asp 
 1025                1030                1035                1040
Ile Tyr Asn Glu Leu Lys Glu Thr Tyr Pro Asn Tyr Leu Pro Leu Tyr 
                 1045                1050                1055
Val Ala Arg Leu His Gln Leu Asp Ala Glu Lys Glu Arg Met Lys Arg 
             1060                1065                1070
Leu Asn Glu Ile Val Asp Ala Ala Asn Ala Val Ile Ser His Ile Asp 
         1075                1080                1085
Gln Thr Ala Leu Ala Val Tyr Ile Ala Met Lys Thr Asp Pro Arg Pro 
     1090                1095                1100
Asp Ala Ala Thr Ile Lys Asn Asp Met Asp Lys Gln Lys Ser Thr Leu 
 1105                1110                1115                1120
Val Asp Ala Leu Cys Arg Lys Gly Cys Ala Leu Ala Asp His Leu Leu 
                 1125                1130                1135
His Thr Gln Ala Gln Asp Gly Ala Ile Ser Thr Asp Ala Glu Gly Lys 
             1140                1145                1150
Glu Glu Glu Gly Glu Ser Pro Leu Asp Ser Leu Ala Glu Thr Phe Trp 
         1155                1160                1165
Glu Thr Thr Lys Trp Thr Asp Leu Phe Asp Asn Lys Val Leu Thr Phe 
     1170                1175                1180
Ala Tyr Lys His Ala Leu Val Asn Lys Met Tyr Gly Arg Gly Leu Lys 
 1185                1190                1195                1200
Phe Ala Thr Lys Leu Val Glu Glu Lys Pro Thr Lys Glu Asn Trp Lys 
                 1205                1210                1215
Asn Cys Ile Gln Leu Met Lys Leu Leu Gly Trp Thr His Cys Ala Ser 
             1220                1225                1230
Phe Thr Glu Asn Trp Leu Pro Ile Met Tyr Pro Pro Asp Tyr Cys Val 
         1235                1240                1245
Phe 
     1250



<210> 7006
<211> 430
<212> DNA
<213> Rattus norvegicus
<308> AI176422
<400> 7006

aatcataaa  gtgatttga  ttacctgca  gatgttgtt  tttaaggtcataaagttt  attaatgac  aatatttca  gattttatg  gacgttaga  acaaagttt  60
ttacttcag  gtttgaagg  cacttgttc  gaagttatc  aaacatatg  gaggttagt  120
tggcataca  ttacagtat  ctagaaact  gctgtcaag  gtgccagta  gtggaggca  180
ttgggcttt  catgccatt  taagcaggt  ctcctccac  ttctgggac  acccagtta  240
tattttgac  tgggtcttt  atatcacat  ttttacaat  cacacagtt  tgagcattt  300
tctgtaacc  taagtctgg  catcacagc  ggccctcaa  tcaaacttt  tataaagct  360
cttggctag  tgtccatgg  agccttctg  aaagattgt  actttggca  gcaactcca  420
gcctcgtgcc  430



<210> 7007
<211> 418
<212> DNA
<213> Homo sapiens
<308> BE172552
<400> 7007

acactcaca  actctctct  tatagatgt  caatagaaa  cacacacac  ctctctata  60
gtgttcaat  gaaaacaca  acacacact  tacaggtgt  caatagaaa  aacacacac  120
cacactcac  ctctctctt  ctgtaaata  aaatctgtc  atatatgat  ggcccgagc  180
gcgattctg  cctgcagga  tttatgaat  tgtacctgt  gaacaaggt  atggatttc  240
gttacagat  aatgctcag  actgtgtac  ttgtaaaac  tgtgatatt  aagatccaa  300
tcagaatat  aactgggtg  tacctgaag  tggaggagg  cctgcttac  atggaatgt  360
aactgcagc  agccagttt  tttcaagta  ggcaagcta  cgttacaat  tgtagaaa  418



<210> 7008
<211> 617
<212> PRT
<213> Homo sapiens
<308> NP_004444
<400> 7008

Met Leu Val Pro Leu Ala Lys Leu Ser Cys Leu Ala Tyr Gln Cys Phe 
  1               5                  10                  15
His Ala Leu Lys Ile Lys Lys Asn Tyr Leu Pro Leu Cys Ala Ile Arg 
             20                  25                  30
Trp Ser Ser Thr Ser Thr Val Pro Arg Ile Thr Thr His Tyr Thr Ile 
         35                  40                  45
Tyr Pro Arg Asp Lys Asp Lys Arg Trp Glu Gly Val Asn Met Glu Arg 
     50                  55                  60
Phe Ala Glu Glu Ala Asp Val Val Ile Val Gly Ala Gly Pro Ala Gly 
 65                  70                  75                  80
Leu Ser Ala Ala Val Arg Leu Lys Gln Leu Ala Val Ala His Glu Lys 
                 85                  90                  95
Asp Ile Arg Val Cys Leu Val Glu Lys Ala Ala Gln Ile Gly Ala His 
             100                105                110
Thr Leu Ser Gly Ala Cys Leu Asp Pro Gly Ala Phe Lys Glu Leu Phe 
         115                120                125
Pro Asp Trp Lys Glu Lys Gly Ala Pro Leu Asn Thr Pro Val Thr Glu 
     130                135                140
Asp Arg Phe Gly Ile Leu Thr Glu Lys Tyr Arg Ile Pro Val Pro Ile 
 145                150                155                160
Leu Pro Gly Leu Pro Met Asn Asn His Gly Asn Tyr Ile Val Arg Leu 
                 165                170                175
Gly His Leu Val Ser Trp Met Gly Glu Gln Ala Glu Ala Leu Gly Val 
             180                185                190
Glu Val Tyr Pro Gly Tyr Ala Ala Ala Glu Val Leu Phe His Asp Asp 
         195                200                205
Gly Ser Val Lys Gly Ile Ala Thr Asn Asp Val Gly Ile Gln Lys Asp 
     210                215                220
Gly Ala Pro Lys Ala Thr Phe Glu Arg Gly Leu Glu Leu His Ala Lys 
 225                230                235                240
Val Thr Ile Phe Ala Glu Gly Cys His Gly His Leu Ala Lys Gln Leu 
                 245                250                255
Tyr Lys Lys Phe Asp Leu Arg Ala Asn Cys Glu Pro Gln Thr Tyr Gly 
             260                265                270
Ile Gly Leu Lys Glu Leu Trp Val Ile Asp Glu Lys Asn Trp Lys Pro 
         275                280                285
Gly Arg Val Asp His Thr Val Gly Trp Pro Leu Asp Arg His Thr Tyr 
     290                295                300
Gly Gly Ser Phe Leu Tyr His Leu Asn Glu Gly Glu Pro Leu Val Ala 
 305                310                315                320
Leu Gly Leu Val Val Gly Leu Asp Tyr Gln Asn Pro Tyr Leu Ser Pro 
                 325                330                335
Phe Arg Glu Phe Gln Arg Trp Lys His His Pro Ser Ile Arg Pro Thr 
             340                345                350
Leu Glu Gly Gly Lys Arg Ile Ala Tyr Gly Ala Arg Ala Leu Asn Glu 
         355                360                365
Gly Gly Phe Gln Ser Ile Pro Lys Leu Thr Phe Pro Gly Gly Leu Leu 
     370                375                380
Ile Gly Cys Ser Pro Gly Phe Met Asn Val Pro Lys Ile Lys Gly Thr 
 385                390                395                400
His Thr Ala Met Lys Ser Gly Ile Leu Ala Ala Glu Ser Ile Phe Asn 
                 405                410                415
Gln Leu Thr Ser Glu Asn Leu Gln Ser Lys Thr Ile Gly Leu His Val 
             420                425                430
Thr Glu Tyr Glu Asp Asn Leu Lys Asn Ser Trp Val Trp Lys Glu Leu 
         435                440                445
Tyr Ser Val Arg Asn Ile Arg Pro Ser Cys His Gly Val Leu Gly Val 
     450                455                460
Tyr Gly Gly Met Ile Tyr Thr Gly Ile Phe Tyr Trp Ile Leu Arg Gly 
 465                470                475                480
Met Glu Pro Trp Thr Leu Lys His Lys Gly Ser Asp Phe Glu Arg Leu 
                 485                490                495
Lys Pro Ala Lys Asp Cys Thr Pro Ile Glu Tyr Pro Lys Pro Asp Gly 
             500                505                510
Gln Ile Ser Phe Asp Leu Leu Ser Ser Val Ala Leu Ser Gly Thr Asn 
         515                520                525
His Glu His Asp Gln Pro Ala His Leu Thr Leu Arg Asp Asp Ser Ile 
     530                535                540
Pro Val Asn Arg Asn Leu Ser Ile Tyr Asp Gly Pro Glu Gln Arg Phe 
 545                550                555                560
Cys Pro Ala Gly Val Tyr Glu Phe Val Pro Val Glu Gln Gly Asp Gly 
                 565                570                575
Phe Arg Leu Gln Ile Asn Ala Gln Asn Cys Val His Cys Lys Thr Cys 
             580                585                590
Asp Ile Lys Asp Pro Ser Gln Asn Ile Asn Trp Val Val Pro Glu Gly 
         595                600                605
Gly Gly Gly Pro Ala Tyr Asn Gly Met 
     610                615



<210> 7009
<211> 430
<212> DNA
<213> Rattus norvegicus
<308> AI176422
<400> 7009

ataaagttt  attaatgac  aatatttca  gattttatg  gacgttaga  acaaagttt  60
ttacttcag  gtttgaagg  cacttgttc  gaagttatc  aaacatatg  gaggttagt  120
tggcataca  ttacagtat  ctagaaact  gctgtcaag  gtgccagta  gtggaggca  180
ttgggcttt  catgccatt  taagcaggt  ctcctccac  ttctgggac  acccagtta  240
tattttgac  tgggtcttt  atatcacat  ttttacaat  cacacagtt  tgagcattt  300
tctgtaacc  taagtctgg  catcacagc  ggccctcaa  tcaaacttt  tataaagct  360
cttggctag  tgtccatgg  agccttctg  aaagattgt  actttggca  gcaactcca  420
gcctcgtgcc  430



<210> 7010
<211> 418
<212> DNA
<213> Homo sapiens
<308> BE172552
<400> 7010

acactcaca  actctctct  tatagatgt  caatagaaa  cacacacac  ctctctata  60
gtgttcaat  gaaaacaca  acacacact  tacaggtgt  caatagaaa  aacacacac  120
cacactcac  ctctctctt  ctgtaaata  aaatctgtc  atatatgat  ggcccgagc  180
gcgattctg  cctgcagga  tttatgaat  tgtacctgt  gaacaaggt  atggatttc  240
gttacagat  aatgctcag  actgtgtac  ttgtaaaac  tgtgatatt  aagatccaa  300
tcagaatat  aactgggtg  tacctgaag  tggaggagg  cctgcttac  atggaatgt  360
aactgcagc  agccagttt  tttcaagta  ggcaagcta  cgttacaat  tgtagaaa  418



<210> 7011
<211> 617
<212> PRT
<213> Homo sapiens
<308> NP_004444
<400> 7011

Met Leu Val Pro Leu Ala Lys Leu Ser Cys Leu Ala Tyr Gln Cys Phe 
  1               5                  10                  15
His Ala Leu Lys Ile Lys Lys Asn Tyr Leu Pro Leu Cys Ala Ile Arg 
             20                  25                  30
Trp Ser Ser Thr Ser Thr Val Pro Arg Ile Thr Thr His Tyr Thr Ile 
         35                  40                  45
Tyr Pro Arg Asp Lys Asp Lys Arg Trp Glu Gly Val Asn Met Glu Arg 
     50                  55                  60
Phe Ala Glu Glu Ala Asp Val Val Ile Val Gly Ala Gly Pro Ala Gly 
 65                  70                  75                  80
Leu Ser Ala Ala Val Arg Leu Lys Gln Leu Ala Val Ala His Glu Lys 
                 85                  90                  95
Asp Ile Arg Val Cys Leu Val Glu Lys Ala Ala Gln Ile Gly Ala His 
             100                105                110
Thr Leu Ser Gly Ala Cys Leu Asp Pro Gly Ala Phe Lys Glu Leu Phe 
         115                120                125
Pro Asp Trp Lys Glu Lys Gly Ala Pro Leu Asn Thr Pro Val Thr Glu 
     130                135                140
Asp Arg Phe Gly Ile Leu Thr Glu Lys Tyr Arg Ile Pro Val Pro Ile 
 145                150                155                160
Leu Pro Gly Leu Pro Met Asn Asn His Gly Asn Tyr Ile Val Arg Leu 
                 165                170                175
Gly His Leu Val Ser Trp Met Gly Glu Gln Ala Glu Ala Leu Gly Val 
             180                185                190
Glu Val Tyr Pro Gly Tyr Ala Ala Ala Glu Val Leu Phe His Asp Asp 
         195                200                205
Gly Ser Val Lys Gly Ile Ala Thr Asn Asp Val Gly Ile Gln Lys Asp 
     210                215                220
Gly Ala Pro Lys Ala Thr Phe Glu Arg Gly Leu Glu Leu His Ala Lys 
 225                230                235                240
Val Thr Ile Phe Ala Glu Gly Cys His Gly His Leu Ala Lys Gln Leu 
                 245                250                255
Tyr Lys Lys Phe Asp Leu Arg Ala Asn Cys Glu Pro Gln Thr Tyr Gly 
             260                265                270
Ile Gly Leu Lys Glu Leu Trp Val Ile Asp Glu Lys Asn Trp Lys Pro 
         275                280                285
Gly Arg Val Asp His Thr Val Gly Trp Pro Leu Asp Arg His Thr Tyr 
     290                295                300
Gly Gly Ser Phe Leu Tyr His Leu Asn Glu Gly Glu Pro Leu Val Ala 
 305                310                315                320
Leu Gly Leu Val Val Gly Leu Asp Tyr Gln Asn Pro Tyr Leu Ser Pro 
                 325                330                335
Phe Arg Glu Phe Gln Arg Trp Lys His His Pro Ser Ile Arg Pro Thr 
             340                345                350
Leu Glu Gly Gly Lys Arg Ile Ala Tyr Gly Ala Arg Ala Leu Asn Glu 
         355                360                365
Gly Gly Phe Gln Ser Ile Pro Lys Leu Thr Phe Pro Gly Gly Leu Leu 
     370                375                380
Ile Gly Cys Ser Pro Gly Phe Met Asn Val Pro Lys Ile Lys Gly Thr 
 385                390                395                400
His Thr Ala Met Lys Ser Gly Ile Leu Ala Ala Glu Ser Ile Phe Asn 
                 405                410                415
Gln Leu Thr Ser Glu Asn Leu Gln Ser Lys Thr Ile Gly Leu His Val 
             420                425                430
Thr Glu Tyr Glu Asp Asn Leu Lys Asn Ser Trp Val Trp Lys Glu Leu 
         435                440                445
Tyr Ser Val Arg Asn Ile Arg Pro Ser Cys His Gly Val Leu Gly Val 
     450                455                460
Tyr Gly Gly Met Ile Tyr Thr Gly Ile Phe Tyr Trp Ile Leu Arg Gly 
 465                470                475                480
Met Glu Pro Trp Thr Leu Lys His Lys Gly Ser Asp Phe Glu Arg Leu 
                 485                490                495
Lys Pro Ala Lys Asp Cys Thr Pro Ile Glu Tyr Pro Lys Pro Asp Gly 
             500                505                510
Gln Ile Ser Phe Asp Leu Leu Ser Ser Val Ala Leu Ser Gly Thr Asn 
         515                520                525
His Glu His Asp Gln Pro Ala His Leu Thr Leu Arg Asp Asp Ser Ile 
     530                535                540
Pro Val Asn Arg Asn Leu Ser Ile Tyr Asp Gly Pro Glu Gln Arg Phe 
 545                550                555                560
Cys Pro Ala Gly Val Tyr Glu Phe Val Pro Val Glu Gln Gly Asp Gly 
                 565                570                575
Phe Arg Leu Gln Ile Asn Ala Gln Asn Cys Val His Cys Lys Thr Cys 
             580                585                590
Asp Ile Lys Asp Pro Ser Gln Asn Ile Asn Trp Val Val Pro Glu Gly 
         595                600                605
Gly Gly Gly Pro Ala Tyr Asn Gly Met 
     610                615



<210> 7012
<211> 534
<212> DNA
<213> Rattus norvegicus
<308> AI176461
<400> 7012

atttttttt  tcttttgtt  tgttttctg  ttttaaaaa  aaaaatttg  gttgcaggt  60
aggtgagtc  gttctgaag  accagcagt  ctgttggtg  gacagaatt  tctacaggc  120
ggtaaacct  cgccaacaa  agctaccac  aaagcagcc  gctgccgcc  ctgcaaggg  180
agctgggag  aggaggaca  cgaggacat  gccaagtct  gatgggaag  tgcagtggg  240
acctgatgc  gctctactg  gggtgctgg  gccaccgtt  gaagggcga  gtgagaggg  300
acactacac  ggacggctg  acaggcggg  gggcctggc  ggaggctcc  ctggtggtc  360
ggcagctct  cctgtcctt  agctctcgt  tcaccctct  agtgatccg  ccacacatc  420
ggccaatca  gaacaatat  cagatgctc  cgctgatca  agacaggat  taattcttt  480
atggggatg  catcacttg  atggcaaga  cagagaagc  gtccgcctc  tgcc  534



<210> 7013
<211> 1171
<212> PRT
<213> Rattus norvegicus
<308> Q62638
<400> 7013

Met Ala Val Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
  1               5                  10                  15
Leu Gln Leu Leu Leu Leu Val Ala Ala Gly Val Gln Asn Ser His Gly 
             20                  25                  30
Gln Gly Gln Gly Leu Gly Val Asn Phe Gly Pro Phe Ala Gly Gln Ala 
         35                  40                  45
Gly Gly Gly Asn Pro Val Gly Gln Gln Pro Pro Gln Leu Pro Gln Leu 
     50                  55                  60
Ser Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Gln Gln Gln Gln Pro 
 65                  70                  75                  80
Phe Pro Ala Gly Gly Leu Pro Ala Arg Arg Gly Gly Ala Gly Pro Gly 
                 85                  90                  95
Gly Thr Gly Gly Gly Trp Lys Leu Ala Glu Glu Glu Ser Cys Arg Glu 
             100                105                110
Asp Val Thr Arg Val Cys Pro Lys His Thr Trp Ser Asn Asn Leu Ala 
         115                120                125
Val Leu Glu Cys Leu Gln Asp Val Arg Glu Pro Glu Asn Glu Ile Ser 
     130                135                140
Ser Asp Cys Asn His Leu Leu Trp Asn Tyr Lys Leu Asn Leu Thr Thr 
 145                150                155                160
Asp Pro Lys Phe Glu Ser Val Ala Arg Glu Val Cys Lys Ser Thr Ile 
                 165                170                175
Ser Glu Ile Lys Glu Cys Ala Glu Glu Pro Val Gly Lys Gly Tyr Met 
             180                185                190
Val Ser Cys Leu Val Asp His Arg Gly Asn Ile Thr Glu Tyr Gln Cys 
         195                200                205
His Gln Tyr Ile Thr Lys Met Thr Ala Ile Ile Phe Ser Asp Tyr Arg 
     210                215                220
Leu Ile Cys Gly Phe Met Asp Asp Cys Lys Asn Asp Ile Asn Leu Leu 
 225                230                235                240
Lys Cys Gly Ser Ile Arg Leu Gly Glu Lys Asp Ala His Ser Gln Gly 
                 245                250                255
Glu Val Val Ser Cys Leu Glu Lys Gly Leu Val Lys Glu Ala Glu Glu 
             260                265                270
Lys Glu Pro Lys Ile Gln Val Ser Glu Leu Cys Lys Lys Ala Ile Leu 
         275                280                285
Arg Val Ala Glu Leu Ser Ser Asp Asp Phe His Leu Asp Arg His Leu 
     290                295                300
Tyr Phe Ala Cys Arg Asp Asp Arg Glu Arg Phe Cys Glu Asn Thr Gln 
 305                310                315                320
Ala Gly Glu Gly Arg Val Tyr Lys Cys Leu Phe Asn His Lys Phe Glu 
                 325                330                335
Glu Ser Met Ser Glu Lys Cys Arg Glu Ala Leu Thr Thr Arg Gln Lys 
             340                345                350
Leu Ile Ala Gln Asp Tyr Lys Val Ser Tyr Ser Leu Ala Lys Ser Cys 
         355                360                365
Lys Ser Asp Leu Lys Lys Tyr Arg Cys Asn Val Glu Asn Leu Pro Arg 
     370                375                380
Ser Arg Glu Ala Arg Leu Ser Tyr Leu Leu Met Cys Leu Glu Ser Ala 
 385                390                395                400
Val His Arg Gly Arg Gln Val Ser Ser Glu Cys Gln Gly Glu Met Leu 
                 405                410                415
Asp Tyr Arg Arg Met Leu Met Glu Asp Phe Ser Leu Ser Pro Glu Ile 
             420                425                430
Ile Leu Ser Cys Arg Gly Glu Ile Glu His His Cys Ser Gly Leu His 
         435                440                445
Arg Lys Gly Arg Thr Leu His Cys Leu Met Lys Val Val Arg Gly Glu 
     450                455                460
Lys Gly Ser Leu Gly Met Asn Cys Gln Gln Ala Leu Gln Thr Leu Ile 
 465                470                475                480
Gln Glu Thr Asp Pro Gly Ala Asp Tyr Arg Ile Asp Arg Ala Leu Asn 
                 485                490                495
Glu Ala Cys Glu Ser Val Ile Gln Thr Ala Cys Lys His Ile Arg Ser 
             500                505                510
Gly Asp Pro Met Ile Leu Ser Cys Leu Met Glu His Leu Tyr Thr Glu 
         515                520                525
Lys Met Val Glu Asp Cys Glu His Arg Leu Leu Glu Leu Gln Tyr Phe 
     530                535                540
Ile Ser Arg Asp Trp Lys Leu Asp Pro Val Leu Tyr Arg Lys Cys Gln 
 545                550                555                560
Gly Asp Ala Ser Arg Leu Cys His Thr His Gly Trp Asn Glu Thr Ser 
                 565                570                575
Glu Leu Met Pro Pro Gly Ala Val Phe Ser Cys Leu Tyr Arg His Ala 
             580                585                590
Tyr Arg Thr Glu Glu Gln Gly Arg Arg Leu Ser Arg Glu Cys Arg Ala 
         595                600                605
Glu Val Gln Arg Ile Leu His Gln Arg Ala Met Asp Val Lys Leu Asp 
     610                615                620
Pro Ala Leu Gln Asp Lys Cys Leu Ile Asp Leu Gly Lys Trp Cys Ser 
 625                630                635                640
Glu Lys Thr Glu Thr Gly Gln Glu Leu Glu Cys Leu Gln Asp His Leu 
                 645                650                655
Asp Asp Leu Ala Val Glu Cys Arg Asp Ile Val Gly Asn Leu Thr Glu 
             660                665                670
Leu Glu Ser Glu Asp Ile Gln Ile Glu Ala Leu Leu Met Arg Ala Cys 
         675                680                685
Glu Pro Ile Ile His Asn Phe Cys His Asp Val Ala Asp Asn Gln Ile 
     690                695                700
Asp Ser Gly Asp Leu Met Glu Cys Leu Ile Gln Asn Lys His Gln Lys 
 705                710                715                720
Asp Met Asn Glu Lys Cys Ala Ile Gly Val Thr His Phe Gln Leu Val 
                 725                730                735
Gln Met Lys Asp Phe Arg Phe Ser Tyr Lys Phe Lys Met Ala Cys Lys 
             740                745                750
Glu Asp Val Leu Lys Leu Cys Pro Asn Ile Lys Lys Lys Val Asp Val 
         755                760                765
Val Ile Cys Leu Ser Thr Thr Val Arg Asn Asp Thr Leu Gln Glu Ala 
     770                775                780
Lys Glu His Arg Val Ser Leu Lys Cys Arg Lys Gln Leu Arg Val Glu 
 785                790                795                800
Glu Leu Glu Met Thr Glu Asp Ile Arg Leu Glu Pro Asp Leu Tyr Glu 
                 805                810                815
Ala Cys Lys Ser Asp Ile Lys Asn Tyr Cys Ser Thr Val Gln Tyr Gly 
             820                825                830
Asn Ala Gln Ile Ile Glu Cys Leu Lys Glu Asn Lys Lys Gln Leu Ser 
         835                840                845
Thr Arg Cys His Gln Arg Val Phe Lys Leu Gln Glu Thr Glu Met Met 
     850                855                860
Asp Pro Glu Leu Asp Tyr Thr Leu Met Arg Val Cys Lys Gln Met Ile 
 865                870                875                880
Lys Arg Phe Cys Pro Glu Ala Asp Ser Lys Thr Met Leu Gln Cys Leu 
                 885                890                895
Lys Gln Asn Lys Asn Ser Glu Leu Met Asp Pro Lys Cys Lys Gln Met 
             900                905                910
Ile Thr Lys Arg Gln Ile Thr Gln Asn Thr Asp Tyr Arg Leu Asn Pro 
         915                920                925
Val Leu Arg Lys Ala Cys Lys Ala Asp Ile Pro Lys Phe Cys His Gly 
     930                935                940
Ile Leu Thr Lys Ala Lys Asp Asp Ser Glu Leu Glu Gly Gln Val Ile 
 945                950                955                960
Ser Cys Leu Lys Leu Arg Tyr Ala Asp Gln Arg Leu Ser Ser Asp Cys 
                 965                970                975
Glu Asp Gln Ile Arg Ile Ile Thr Gln Glu Ser Ala Leu Asp Tyr Arg 
             980                985                990
Leu Asp Pro Gln Leu Gln Leu His Cys Ser Asp Glu Ile Ala Asn Leu 
         995                1000                1005
Cys Ala Glu Glu Ala Ala Ala Gln Glu Gln Thr Gly Gln Val Glu Glu 
     1010                1015                1020
Cys Leu Lys Val Asn Leu Leu Lys Ile Arg Thr Glu Leu Cys Lys Lys 
 1025                1030                1035                1040
Glu Val Leu Asn Met Leu Lys Glu Ser Lys Ala Asp Ile Phe Val Asp 
                 1045                1050                1055
Pro Val Leu His Thr Ala Cys Ala Leu Asp Ile Lys His His Cys Ala 
             1060                1065                1070
Ala Ile Thr Pro Gly Arg Gly Arg Gln Met Ser Cys Leu Met Glu Ala 
         1075                1080                1085
Leu Glu Asp Lys Arg Val Arg Leu Gln Pro Glu Cys Lys Lys Arg Leu 
     1090                1095                1100
Asn Asp Arg Ile Glu Met Trp Ser Tyr Ala Ala Lys Val Ala Pro Ala 
 1105                1110                1115                1120
Asp Gly Phe Ser Asp Leu Ala Met Gln Val Met Thr Ser Pro Ser Lys 
                 1125                1130                1135
Asn Tyr Ile Leu Ser Val Ile Ser Gly Ser Ile Cys Ile Leu Phe Leu 
             1140                1145                1150
Ile Gly Leu Met Cys Gly Arg Ile Thr Lys Arg Val Thr Arg Glu Leu 
         1155                1160                1165
Lys Asp Arg 
     1170



<210> 7014
<211> 3901
<212> DNA
<213> Homo sapiens
<308> U64791
<400> 7014

aagatggcg  cgtgtggac  tgtacggag  atgttccgc  tgtcggcgg  gctgcatct  60
ctgctgcta  tcgcggccg  ggccgagaa  ctccccggc  atggcgtcc  cagccaggg  120
cagggtccc  gggccaact  tgtgtcctt  gtagggcag  ccggaggcg  cggcccggc  180
ggtcagcag  tgccccagc  gcttcagtc  tcgcagctt  agcagcaac  gcagcagca  240
caacagcaa  agcagcttc  gccgccgca  ccgcctttc  cggcgggtg  gcctccggc  300
cggcgggga  gagcggggg  tggtggggg  tggaagctg  cggaggaag  gtcctgcag  360
gaggacgtg  cccgcgtgt  ccctaagca  acctggagc  acaacctgg  ggtgctcga  420
tgcctgcag  atgtgaggg  gcctgaaaa  gaaatttct  cagactgca  tcatttgtt  480
tggaattat  agctgaacc  aactacaga  cccaaattt  aatctgtgg  cagagaggt  540
tgcaaatct  ctataacag  gattaaaga  tgtgctgat  aaccggttg  aaaaggtta  600
atggtttcc  gcttagtgg  tcaccgagg  aacatcact  agtatcagt  tcaccagta  660
attaccaag  tgacggcca  catttttag  gattaccgt  taatctgtg  cttcatgga  720
gactgcaaa  atgacatca  cattctgaa  tgtggcagt  ttcggcttg  agaaaagga  780
gcacattca  aaggtgagg  ggtatcatg  ttggagaaa  gcctggtga  agaagcaga  840
gaaagagaa  ccaagattc  agtttctga  ctctgcaag  aagccattc  ccgggtggc  900
gagctgtca  cggatgact  tcacttaga  cggcattta  attttgctt  ccgagatga  960
cgggagcgt  tttgtgaaa  tacacaagc  ggtgagggc  gagtgtata  gtgcctctt  1020
aaccataaa  ttgaagaat  catgagtga  aagtgtcga  aagcactta  aacccgcca  1080
aagctgatt  cccaggatt  taaagtcag  tattcattg  ccaaatcct  taaaagtga  1140
ttgaagaaa  accggtgca  tgtggaaaa  cttccgcga  cgcgtgaag  caggctctc  1200
tacttgtta  tgtgcctgg  gtcagctgt  cacagaggg  gacaagtca  cagtgagtg  1260
cagggggag  tgctggatt  ccgacgcat  ttgatggaa  acttttctc  gagccctga  1320
atcatccta  gctgtcggg  ggagattga  caccattgt  ccggattac  tcgaaaagg  1380
cggacccta  actgtctga  gaaagtagt  cgaggggag  aggggaacc  tggaatgaa  1440
tgccagcag  cgcttcaaa  actgattca  gagactgac  ctggtgcag  ttaccgcat  1500
gatcgagct  tgaatgaag  ttgtgaatc  gtaatccag  cagcctgca  acatataag  1560
tctggagac  caatgatct  gtcgtgcct  atggaacat  tatacacag  gaagatggt  1620
gaagactgt  aacaccgtc  cttagagct  cagtatttc  tctcccggg  ttggaagct  1680
gaccctgtc  tgtaccgca  gtgccaggg  gacgcttct  gtctttgcc  cacccacgg  1740
tggaatgag  ccagtgaat  tatgcctca  ggagctgtg  tctcttgtt  atacagaca  1800
gcctaccgc  ctgaggaac  gggaaggag  ctctcacgg  agtgccgag  tgaagtcca  1860
aggatccta  accagcgtg  catggatgt  aagctggat  ctgccctcc  ggataagtg  1920
ctgattgat  tgggaaaat  gtgcagtga  aaaacagag  ctggacagg  gctggagtg  1980
cttcaggac  atctggatg  cttggtggt  gagtgtaga  atatagttg  caacctcac  2040
gagttagaa  cagaggata  tcaaataga  gccttgctg  tgagagcct  tgagcccat  2100
attcagaac  tctgccacg  tgtggcaga  aaccagata  actctgggg  cctgatgga  2160
tgtctgata  agaacaaac  ccagaagga  atgaacgag  agtgtgcca  cggagttac  2220
cacttccag  tggtgcaga  gaaggattt  cggttttct  acaagttta  aatggcctg  2280
aaggaggac  tgttgaagc  ttgcccaaa  ataaaaaag  aggtggacg  ggtgatctg  2340
ctgagcacg  ccgtgcgca  tgacactct  caggaagcc  aggagcaca  ggtgtccct  2400
aagtgccgc  ggcagctcc  tgtggagga  ctggagatg  cggaggaca  ccgcttgga  2460
ccagatcta  acgaagcct  caagagtga  atcaaaaac  tctgttccg  tgtgcaata  2520
ggcaacgct  agattatcg  atgtctgaa  gaaaacaag  agcagctaa  cacccgctg  2580
caccaaaaa  tatttaagc  gcaggagac  gagatgatg  acccagagc  agactacac  2640
ctcatgagg  tctgcaagc  gatgataaa  aggttctgt  cggaagcag  ttctaaaac  2700
atgttgcag  gcttgaagc  aaataaaaa  agtgaattg  tggatccca  atgcaaaca  2760
atgataacc  agcgccaga  cacccagaa  acagattac  gcttaaacc  catgttaag  2820
aaagcctgt  aagctgaca  tcctaaatt  tgtcacggt  tcctgacta  ggccaagga  2880
gattcagaa  tagaaggac  agtcatctc  tgcctgaag  tgagatatg  tgaccagcg  2940
ctgtcttca  actgtgaag  ccagatccg  atcattatc  aggagtccg  cctggacta  3000
cgcctggat  ctcagctcc  gctgcactg  tcagacgag  tctccagtc  atgtgctga  3060
gaagcagca  cccaagagc  gacaggtca  gtggaggag  gcctcaagg  caacctgct  3120
aagatcaaa  cagaattgt  taaaaagga  gtgctaaac  tgctgaagg  aagcaaagc  3180
gacatcttt  ttgacccgg  acttcatac  gcttgtgcc  tggacatta  acaccactg  3240
gcagccatc  cccctggcc  cgggcgtca  atgtcctgt  tcatggaag  actggagga  3300
aagcgggtg  ggttacagc  cgagtgcaa  aagcgcctc  atgaccgga  tgagatgtg  3360
agttacgca  caaaggtgg  cccagcaga  ggcttctct  atcttgcca  gcaagtaat  3420
acgtctcca  ctaagaact  cattctctc  gtgatcagt  ggagcatct  tatattgtt  3480
ctgattggc  tgatgtgtg  acggatcac  aagcgagtg  cacgagagc  caaggacag  3540
tagagccac  ttgaccacc  aaggaacta  ctatccagt  cccagtttg  acagccctc  3600
tgtatagca  ccccactca  ctcgctctt  tcagaagtg  caccaaccc  gtgttagag  3660
attagcaga  gtccactgc  ttgtcccat  cagcctcca  tcgtgtcca  ggtgtcctc  3720
tcctcctca  cgtgcagca  cagcagctg  tcgctgggg  tactgcctt  gtttggcaa  3780
cttgggttt  cctgcctgt  gacaagtct  tctcatacc  acagaactt  cggtacttc  3840
agaaccaac  cacctgacc  gcaactcaa  ggctttttt  agaaaacca  caaaaaaaa  3900
a  3901



<210> 7015
<211> 1179
<212> PRT
<213> Homo sapiens
<308> Q92896
<400> 7015

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
  1               5                  10                  15
Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
             20                  25                  30
His Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
         35                  40                  45
Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
     50                  55                  60
Gln Leu Leu Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
 65                  70                  75                  80
Gln Gln Gln Gln Leu Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                 85                  90                  95
Pro Pro Ala Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu 
             100                105                110
Ala Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys 
         115                120                125
His Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val 
     130                135                140
Arg Glu Pro Glu Asn Glu Ile Ser Ser Asp Cys Asn His Leu Leu Trp 
 145                150                155                160
Asn Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys Phe Glu Ser Val Ala 
                 165                170                175
Arg Glu Val Cys Lys Ser Thr Ile Thr Glu Ile Lys Glu Cys Ala Asp 
             180                185                190
Glu Pro Val Gly Lys Gly Tyr Met Val Ser Cys Leu Val Asp His Arg 
         195                200                205
Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr Ile Thr Lys Met Thr 
     210                215                220
Ala Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys Gly Phe Met Asp Asp 
 225                230                235                240
Cys Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly Ser Ile Arg Leu Gly 
                 245                250                255
Glu Lys Asp Ala His Ser Gln Gly Glu Val Val Ser Cys Leu Glu Lys 
             260                265                270
Gly Leu Val Lys Glu Ala Glu Glu Arg Glu Pro Lys Ile Gln Val Ser 
         275                280                285
Glu Leu Cys Lys Lys Ala Ile Leu Arg Val Ala Glu Leu Ser Ser Asp 
     290                295                300
Asp Phe His Leu Asp Arg His Leu Tyr Phe Ala Cys Arg Asp Asp Arg 
 305                310                315                320
Glu Arg Phe Cys Glu Asn Thr Gln Ala Gly Glu Gly Arg Val Tyr Lys 
                 325                330                335
Cys Leu Phe Asn His Lys Phe Glu Glu Ser Met Ser Glu Lys Cys Arg 
             340                345                350
Glu Ala Leu Thr Thr Arg Gln Lys Leu Ile Ala Gln Asp Tyr Lys Val 
         355                360                365
Ser Tyr Ser Leu Ala Lys Ser Cys Lys Ser Asp Leu Lys Lys Tyr Arg 
     370                375                380
Cys Asn Val Glu Asn Leu Pro Arg Ser Arg Glu Ala Arg Leu Ser Tyr 
 385                390                395                400
Leu Leu Met Cys Leu Glu Ser Ala Val His Arg Gly Arg Gln Val Ser 
                 405                410                415
Ser Glu Cys Gln Gly Glu Met Leu Asp Tyr Arg Arg Met Leu Met Glu 
             420                425                430
Asp Phe Ser Leu Ser Pro Glu Ile Ile Leu Ser Cys Arg Gly Glu Ile 
         435                440                445
Glu His His Cys Ser Gly Leu His Arg Lys Gly Arg Thr Leu His Cys 
     450                455                460
Leu Met Lys Val Val Arg Gly Glu Lys Gly Asn Leu Gly Met Asn Cys 
 465                470                475                480
Gln Gln Ala Leu Gln Thr Leu Ile Gln Glu Thr Asp Pro Gly Ala Asp 
                 485                490                495
Tyr Arg Ile Asp Arg Ala Leu Asn Glu Ala Cys Glu Ser Val Ile Gln 
             500                505                510
Thr Ala Cys Lys His Ile Arg Ser Gly Asp Pro Met Ile Leu Ser Cys 
         515                520                525
Leu Met Glu His Leu Tyr Thr Glu Lys Met Val Glu Asp Cys Glu His 
     530                535                540
Arg Leu Leu Glu Leu Gln Tyr Phe Ile Ser Arg Asp Trp Lys Leu Asp 
 545                550                555                560
Pro Val Leu Tyr Arg Lys Cys Gln Gly Asp Ala Ser Arg Leu Cys His 
                 565                570                575
Thr His Gly Trp Asn Glu Thr Ser Glu Phe Met Pro Gln Gly Ala Val 
             580                585                590
Phe Ser Cys Leu Tyr Arg His Ala Tyr Arg Thr Glu Glu Gln Gly Arg 
         595                600                605
Arg Leu Ser Arg Glu Cys Arg Ala Glu Val Gln Arg Ile Leu His Gln 
     610                615                620
Arg Ala Met Asp Val Lys Leu Asp Pro Ala Leu Gln Asp Lys Cys Leu 
 625                630                635                640
Ile Asp Leu Gly Lys Trp Cys Ser Glu Lys Thr Glu Thr Gly Gln Glu 
                 645                650                655
Leu Glu Cys Leu Gln Asp His Leu Asp Asp Leu Val Val Glu Cys Arg 
             660                665                670
Asp Ile Val Gly Asn Leu Thr Glu Leu Glu Ser Glu Asp Ile Gln Ile 
         675                680                685
Glu Ala Leu Leu Met Arg Ala Cys Glu Pro Ile Ile Gln Asn Phe Cys 
     690                695                700
His Asp Val Ala Asp Asn Gln Ile Asp Ser Gly Asp Leu Met Glu Cys 
 705                710                715                720
Leu Ile Gln Asn Lys His Gln Lys Asp Met Asn Glu Lys Cys Ala Ile 
                 725                730                735
Gly Val Thr His Phe Gln Leu Val Gln Met Lys Asp Phe Arg Phe Ser 
             740                745                750
Tyr Lys Phe Lys Met Ala Cys Lys Glu Asp Val Leu Lys Leu Cys Pro 
         755                760                765
Asn Ile Lys Lys Lys Val Asp Val Val Ile Cys Leu Ser Thr Thr Val 
     770                775                780
Arg Asn Asp Thr Leu Gln Glu Ala Lys Glu His Arg Val Ser Leu Lys 
 785                790                795                800
Cys Arg Arg Gln Leu Arg Val Glu Glu Leu Glu Met Thr Glu Asp Ile 
                 805                810                815
Arg Leu Glu Pro Asp Leu Tyr Glu Ala Cys Lys Ser Asp Ile Lys Asn 
             820                825                830
Phe Cys Ser Ala Val Gln Tyr Gly Asn Ala Gln Ile Ile Glu Cys Leu 
         835                840                845
Lys Glu Asn Lys Lys Gln Leu Ser Thr Arg Cys His Gln Lys Val Phe 
     850                855                860
Lys Leu Gln Glu Thr Glu Met Met Asp Pro Glu Leu Asp Tyr Thr Leu 
 865                870                875                880
Met Arg Val Cys Lys Gln Met Ile Lys Arg Phe Cys Pro Glu Ala Asp 
                 885                890                895
Ser Lys Thr Met Leu Gln Cys Leu Lys Gln Asn Lys Asn Ser Glu Leu 
             900                905                910
Met Asp Pro Lys Cys Lys Gln Met Ile Thr Lys Arg Gln Ile Thr Gln 
         915                920                925
Asn Thr Asp Tyr Arg Leu Asn Pro Met Leu Arg Lys Ala Cys Lys Ala 
     930                935                940
Asp Ile Pro Lys Phe Cys His Gly Ile Leu Thr Lys Ala Lys Asp Asp 
 945                950                955                960
Ser Glu Leu Glu Gly Gln Val Ile Ser Cys Leu Lys Leu Arg Tyr Ala 
                 965                970                975
Asp Gln Arg Leu Ser Ser Asp Cys Glu Asp Gln Ile Arg Ile Ile Ile 
             980                985                990
Gln Glu Ser Ala Leu Asp Tyr Arg Leu Asp Pro Gln Leu Gln Leu His 
         995                1000                1005
Cys Ser Asp Glu Ile Ser Ser Leu Cys Ala Glu Glu Ala Ala Ala Gln 
     1010                1015                1020
Glu Gln Thr Gly Gln Val Glu Glu Cys Leu Lys Val Asn Leu Leu Lys 
 1025                1030                1035                1040
Ile Lys Thr Glu Leu Cys Lys Lys Glu Val Leu Asn Met Leu Lys Glu 
                 1045                1050                1055
Ser Lys Ala Asp Ile Phe Val Asp Pro Val Leu His Thr Ala Cys Ala 
             1060                1065                1070
Leu Asp Ile Lys His His Cys Ala Ala Ile Thr Pro Gly Arg Gly Arg 
         1075                1080                1085
Gln Met Ser Cys Leu Met Glu Ala Leu Glu Asp Lys Arg Val Arg Leu 
     1090                1095                1100
Gln Pro Glu Cys Lys Lys Arg Leu Asn Asp Arg Ile Glu Met Trp Ser 
 1105                1110                1115                1120
Tyr Ala Ala Lys Val Ala Pro Ala Asp Gly Phe Ser Asp Leu Ala Met 
                 1125                1130                1135
Gln Val Met Thr Ser Pro Ser Lys Asn Tyr Ile Leu Ser Val Ile Ser 
             1140                1145                1150
Gly Ser Ile Cys Ile Leu Phe Leu Ile Gly Leu Met Cys Gly Arg Ile 
         1155                1160                1165
Thr Lys Arg Val Thr Arg Glu Leu Lys Asp Arg 
     1170                1175



<210> 7016
<211> 650
<212> DNA
<213> Rattus norvegicus
<308> AI176488
<400> 7016

ttcaagcac  tgatttgtc  tgatttaat  cctttttaa  tgccctcaa  aactgaggg  60
aaaataaat  cactcaaaa  tattttaaa  tctttttaa  cccctcaat  tagagtcca  120
gggctgaag  acttataat  atgattccc  tttagatat  aatttataa  ttgcacttg  180
ctctgttaa  tgtttcttt  gtggggaaa  tattatatt  atttttact  ttgcatgca  240
aggtaaccc  ttacccaca  agaggcatt  cttccatag  gcctttgag  tcaaaccat  300
ttttcccta  ttttctttt  ttttccttt  taagatttt  aaactgggt  acacactgg  360
aaaggctgg  ttaagggcc  aaatttaat  aatctgtac  gataactaa  ggctacaga  420
atttttata  atatatata  ataattttt  ttaactttt  gaaatcaga  tgcttataa  480
atggctggc  catggctct  tccccagcc  ctctgacgc  gcctcctag  cttcgttgt  540
gagataacc  ggaatagtg  ctccatgcg  aaacaacaa  aatactaac  aagaaaact  600
gcttatcat  caaatatta  ggcatctag  aagtcagtt  aaatttattg  650



<210> 7017
<211> 284
<212> PRT
<213> Rattus norvegicus
<308> BAA25292
<400> 7017

Leu Phe Lys Gly Ile Pro Leu Glu Ser Thr Asp Gly Glu Arg Leu Met 
  1               5                  10                  15
Lys Ser Pro His Cys Thr Asn Pro Ala Leu Cys Val Gln Pro His His 
             20                  25                  30
Ile Thr Val Ser Val Lys Glu Leu Asp Leu Phe Leu Ala Tyr Tyr Val 
         35                  40                  45
Gln Glu Gln Asp Ser Gly Gln Ser Gly Ser Pro Ser His Asn Asp Pro 
     50                  55                  60
Ala Lys Asn Pro Pro Gly Tyr Leu Glu Asp Ser Phe Val Lys Ser Gly 
 65                  70                  75                  80
Val Phe Asn Val Ser Glu Leu Val Arg Val Ser Arg Thr Pro Ile Thr 
                 85                  90                  95
Gln Gly Thr Gly Val Asn Phe Pro Ile Gly Glu Ile Pro Ser Gln Pro 
             100                105                110
Tyr Tyr His Asp Met Asn Ser Gly Val Asn Leu Gln Arg Ser Leu Ser 
         115                120                125
Ser Pro Pro Ser Ser Lys Arg Pro Lys Thr Ile Ser Ile Asp Glu Asn 
     130                135                140
Met Glu Pro Ser Pro Thr Gly Asp Phe Tyr Pro Ser Pro Asn Ser Pro 
 145                150                155                160
Ala Ala Gly Ser Arg Thr Trp His Glu Arg Asp Gln Asp Met Ser Ser 
                 165                170                175
Pro Thr Thr Met Lys Lys Pro Glu Lys Pro Leu Phe Ser Ser Thr Ser 
             180                185                190
Pro Gln Asp Ser Ser Pro Arg Leu Ser Thr Phe Pro Gln His His His 
         195                200                205
Pro Gly Ile Pro Gly Val Ala His Ser Val Ile Ser Thr Arg Thr Pro 
     210                215                220
Pro Pro Pro Ser Pro Leu Pro Phe Pro Thr Gln Ala Ile Leu Pro Pro 
 225                230                235                240
Ala Pro Ser Ser Tyr Phe Ser His Pro Thr Ile Arg Tyr Pro Pro His 
                 245                250                255
Leu Asn Pro Gln Asp Thr Leu Lys Asn Tyr Val Pro Ser Tyr Asp Pro 
             260                265                270
Ser Ser Pro Gln Thr Ser Gln Ser Trp Tyr Leu Gly 
         275                280



<210> 7018
<211> 2424
<212> DNA
<213> Homo sapiens
<308> U85193
<400> 7018

cctggaact  tagcacgcc  agtgaactt  aatctttgg  tatttaagg  ggactgggt  60
tgttgtgaa  ttgcggtga  ccagcgcag  gccccgtcc  gattgatcg  atcgcgggg  120
tcagatgac  gtaaaatga  tagatgaaa  tcttgcttc  cgaagattt  cttgggcat  180
tcccggaaa  tgcgtttta  ggcgaagtc  tgatgtatt  tcccatctg  ctcactcag  240
atgaatttc  cccattcat  gaagcactt  ttccacatg  ccgtgcaat  gcctatact  300
ggttcaacc  gcaggctcg  aaacgcaag  actttaaaa  gcatgagaa  cgaatgtca  360
aggatgaag  aagagcagt  aaagatgag  ttctcagtg  aaagcctga  atcaaacag  420
agtgggcat  caggctcct  gccaaactg  gcaaagata  tcgccagga  tatcgagag  480
actttgtgc  caccgtgac  ggcaagaag  acccgtgct  tgtcttatc  aatcccgac  540
agaagggta  gattaggag  atcgactgc  tgcgacagg  agacaaagt  tggcgtctg  600
atctagtca  ggtgatcct  ttcaaaggc  tccccttgg  aagtaccga  ggagagcgg  660
tcatgaaat  cccacattg  acaaaccca  cactttgtg  ccagccaca  catatcaca  720
tatcagtta  ggagcttga  ttgtttttg  catactacg  gcaggagca  gattctgga  780
aatcaggaa  tccaagcca  aatgatcct  ccaagaatc  tccaggtta  cttgaggat  840
gttttgtaa  atctggagt  ttcaatgta  cagaacttg  aagagtatc  agaacgccc  900
taacccagg  aactggagt  aacttccca  ttggagaaa  cccaagcca  ccatactat  960
atgacatga  ctcgggggt  aatcttcag  ggtctctgt  ttctccacc  agcagcaaa  1020
gacccaaaa  tatatccat  gaygaaaat  tggaaccaa  tcctacagg  gacttttac  1080
cctctccaa  ttcaccagc  gctggaagt  gaacatggc  cgaaagaga  caagatatg  1140
cttctccga  tactatgaa  aagcctgaa  agccattgt  cagctctgc  tctccacag  1200
attcttccc  aagactgag  actttcccc  agcaccacc  tcccggaat  cctggagtt  1260
cacacagtg  catctcaac  cgaactcca  ctccacctt  accgttgcc  tttccaaca  1320
aagctatcc  tcctccagc  ccatcgagc  acttttctc  tccaacaat  agatatcct  1380
cccacctga  tcctcagga  actctgaag  actatgtac  ttcttatga  ccatccagt  1440
cacaaacca  ccagtcctg  tacctgggc  agcttggtt  ctttccaag  gtcaaatag  1500
acacccatc  taccggcca  tgtccaaaa  tacggtttg  acataattg  agaaccttt  1560
cttcaagca  aaacaagca  ctgagggaa  aagaaacac  acaatagtt  aagaaattt  1620
ttttttaaa  aaaaaaaag  aaaagagga  gactggaca  aacaacaca  aggcagaaa  1680
gaaagaaac  gaagaaaga  gataataga  cagcaattg  agcacttac  atcactaat  1740
cccttaagg  taaactgta  tgacataaa  agggtcgat  atatttcac  gatggtaga  1800
cgcagcccc  gcaacgtag  ctttgttac  tgaagtccg  tgggaaata  atgttctgt  1860
tctatgaca  tatatttta  ctgactttc  agatgcctt  atatttgca  gataagcta  1920
ttttattgg  ttagtattc  tgttgttta  gcatggaat  actattcct  gttatctca  1980
caacgaagg  taggaggcg  cgtcagaga  gctgggtga  agagccatg  gccagccat  2040
ttataagca  tctgatttc  aaaagttaa  aaaaatata  gaaatctct  tagccttta  2100
ttatcagta  agatttatt  aatttcggc  cttaaccca  ccttttcca  tgtgtaacc  2160
agtttgaaa  cttaaaaaa  gaaaaaatg  aaaaaaaag  aaaaaaaga  aaaaggaaa  2220
aaacagttt  aacacaaag  ctctatgga  gaaatgcct  tatgtaggt  aagtgttct  2280
tctgcatgc  acagtaaaa  ttaatataa  attttcccc  caaaagaaa  acttaacag  2340
gggcaagtg  aatttatta  atttatatt  ttaaagggg  aattcatgg  ttattaagg  2400
ccttcaggc  cttggggac  ctta  2424



<210> 7019
<211> 420
<212> PRT
<213> Homo sapiens
<308> O00712
<400> 7019

Met Met Tyr Ser Pro Ile Cys Leu Thr Gln Asp Glu Phe His Pro Phe 
  1               5                  10                  15
Met Glu Ala Leu Leu Pro His Val Arg Ala Ile Ala Tyr Thr Trp Phe 
             20                  25                  30
Asn Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg 
         35                  40                  45
Met Ser Lys Asp Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Ser Glu 
     50                  55                  60
Lys Pro Glu Ile Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu 
 65                  70                  75                  80
Arg Lys Asp Ile Arg Gln Glu Tyr Arg Glu Asp Phe Val Leu Thr Val 
                 85                  90                  95
Thr Gly Lys Lys His Pro Cys Cys Val Leu Ser Asn Pro Asp Gln Lys 
             100                105                110
Gly Lys Ile Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp 
         115                120                125
Arg Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu 
     130                135                140
Ser Thr Asp Gly Glu Arg Leu Met Lys Ser Pro His Cys Thr Asn Pro 
 145                150                155                160
Ala Leu Cys Val Gln Pro His His Ile Thr Val Ser Val Lys Glu Leu 
                 165                170                175
Asp Leu Phe Leu Ala Tyr Tyr Val Gln Glu Gln Asp Ser Gly Gln Ser 
             180                185                190
Gly Ser Pro Ser His Asn Asp Pro Ala Lys Asn Pro Pro Gly Tyr Leu 
         195                200                205
Glu Asp Ser Phe Val Lys Ser Gly Val Phe Asn Val Ser Glu Leu Val 
     210                215                220
Arg Val Ser Arg Thr Pro Ile Thr Gln Gly Thr Gly Val Asn Phe Pro 
 225                230                235                240
Ile Gly Glu Ile Pro Ser Gln Pro Tyr Tyr His Asp Met Asn Ser Gly 
                 245                250                255
Val Asn Leu Gln Arg Ser Leu Ser Ser Pro Pro Ser Ser Lys Arg Pro 
             260                265                270
Lys Thr Ile Ser Ile Asp Glu Asn Met Glu Pro Ser Pro Thr Gly Asp 
         275                280                285
Phe Tyr Pro Ser Pro Ser Ser Pro Ala Ala Gly Ser Arg Thr Trp His 
     290                295                300
Glu Arg Asp Gln Asp Met Ser Ser Pro Thr Thr Met Lys Lys Pro Glu 
 305                310                315                320
Lys Pro Leu Phe Ser Ser Ala Ser Pro Gln Asp Ser Ser Pro Arg Leu 
                 325                330                335
Ser Thr Phe Pro Gln His His His Pro Gly Ile Pro Gly Val Ala His 
             340                345                350
Ser Val Ile Ser Thr Arg Thr Pro Pro Pro Pro Ser Pro Leu Pro Phe 
         355                360                365
Pro Thr Gln Ala Ile Leu Pro Pro Ala Pro Ser Ser Tyr Phe Ser His 
     370                375                380
Pro Thr Ile Arg Tyr Pro Pro His Leu Asn Pro Gln Asp Thr Leu Lys 
 385                390                395                400
Asn Tyr Val Pro Ser Tyr Asp Pro Ser Ser Pro Gln Thr Ser Gln Ser 
                 405                410                415
Trp Tyr Leu Gly 
             420



<210> 7020
<211> 575
<212> DNA
<213> Rattus norvegicus
<308> AI176491
<400> 7020

tttttttga  gagcacaag  atttttatt  ctttctttt  ttttctttt  ttttccttt  60
tttcggagc  ggggaccaa  cccagggcc  tgcgcttgc  aggcaagcg  tctaccact  120
agctaaatc  ccaacccct  ttttatttc  ttaacaatg  aaaatatac  cgttgactt  180
actaggaca  attcacatg  aaatttttt  tcatatcca  aactctgga  agatcagag  240
aatgacaaa  atcatcaca  gaagcagac  aattatgtc  ccttgctcc  agcactacg  300
acacaatgc  taaaggact  tagtatctc  aaagtttat  ccagtccat  tcttctttt  360
tactccaaa  catcttcgt  gtgttggtg  atgagataa  tccacatga  aatcgaggt  420
cccaaggtc  gcccaactt  cacccagtt  ggtttggca  tgactggct  ccggacata  480
aactttgac  gtgttgaag  gcagctcgg  agcctggcg  gggccagca  ccgcgaaaa  540
gagcgcagt  ctacgggcg  cgccatcct  gtgcc  575



<210> 7021
<211> 76
<212> PRT
<213> Rattus norvegicus
<308> NP_079799
<400> 7021

Met Ala Pro Ser Val Val Leu Arg Ser Phe Ser Arg Leu Leu Ala Pro 
  1               5                  10                  15
Ala Arg Leu Pro Ser Cys Ser Ser Thr Arg Ser Lys Phe Tyr Val Arg 
             20                  25                  30
Glu Pro Val Asn Ala Lys Pro Asn Trp Leu Ala Val Gly Leu Ser Val 
         35                  40                  45
Gly Ala Ser Val Phe Met Trp Ile Tyr Leu Ile Gln Thr His Asn Glu 
     50                  55                  60
Asp Val Leu Glu Tyr Lys Arg Arg Asn Gly Leu Glu 
 65                  70                  75



<210> 7022
<211> 658
<212> DNA
<213> Rattus norvegicus
<308> AI176504
<400> 7022

caatacaca  atttattat  ctgtaaaaa  caacactac  tgatctcat  taaaataag  60
atttcccaa  ttcagaata  ttacaattt  tagttttaa  atttcattt  gggaaatgt  120
agaagtaaa  acattcata  ctgtggact  cccagcagg  acctagggc  gacatcggt  180
atcaggtcc  tgacagacg  ctggatcga  agtgagtcc  gctctgccg  taaagcagt  240
taggcagta  tgggcgtag  acatcagca  acaggggcg  cagaaccgg  acagcaggg  300
cagcggtat  cagagatcg  tgaagccac  cgatcatgt  atggttctg  gagacagaa  360
catcaccta  ggttgtaaa  ccagaacag  cgtctttgg  gtttactga  ggcagcagt  420
agcggctca  tcacacact  acagggtcc  tgctgttat  agccagcag  gaacagcca  480
agcaagacc  ggcccagga  aaagagcgc  ctcaaccaa  ccacagaga  agtatgaag  540
agcactgag  tgaggagag  tgaaaacat  tgtctcaga  aatatacaa  accattatc  600
gagggaatc  ttaaagtca  tggcaatat  taagtcaca  gctgaattc  ggaaagcc  658



<210> 7023
<211> 674
<212> PRT
<213> Rattus norvegicus
<308> P13264
<400> 7023

Met Met Arg Leu Arg Gly Ser Ala Met Leu Arg Glu Leu Leu Leu Arg 
  1               5                  10                  15
Pro Pro Ala Ala Val Gly Gly Val Leu Arg Arg Thr Gln Pro Leu Gly 
             20                  25                  30
Thr Leu Cys Arg Arg Pro Arg Gly Gly Ser Arg Pro Ala Ala Gly Leu 
         35                  40                  45
Val Ala Ala Ala Arg Leu His Pro Trp Trp Gly Gly Gly Gly Arg Ala 
     50                  55                  60
Lys Gly Pro Gly Ser Gly Gly Leu Ser Ser Ser Pro Ser Glu Ile Leu 
 65                  70                  75                  80
Gln Glu Leu Gly Lys Gly Gly Thr Pro Pro Gln Gln Gln Gln Gln Gln 
                 85                  90                  95
Gln Gln Gln Pro Gly Ala Ser Pro Pro Ala Ala Pro Gly Pro Lys Asp 
             100                105                110
Ser Pro Gly Glu Thr Asp Ala Phe Gly Asn Ser Glu Gly Lys Glu Met 
         115                120                125
Val Ala Ala Gly Asp Asn Lys Val Lys Gln Gly Leu Leu Pro Ser Leu 
     130                135                140
Glu Asp Leu Leu Phe Tyr Thr Ile Ala Glu Gly Gln Glu Lys Ile Pro 
 145                150                155                160
Val His Lys Phe Ile Thr Ala Leu Lys Ser Thr Gly Leu Arg Thr Ser 
                 165                170                175
Asp Pro Arg Leu Lys Glu Cys Met Asp Met Leu Arg Leu Thr Leu Gln 
             180                185                190
Thr Thr Ser Asp Gly Val Met Leu Asp Lys Asp Leu Phe Lys Lys Cys 
         195                200                205
Val Gln Ser Asn Ile Val Leu Leu Thr Gln Ala Phe Arg Arg Lys Phe 
     210                215                220
Val Ile Pro Asp Phe Met Ser Phe Thr Ser His Ile Asp Glu Leu Tyr 
 225                230                235                240
Glu Ser Ala Lys Lys Gln Ser Gly Gly Lys Val Ala Asp Tyr Ile Pro 
                 245                250                255
Gln Leu Ala Lys Phe Ser Pro Asp Leu Trp Gly Val Ser Val Cys Thr 
             260                265                270
Val Asp Gly Gln Arg His Ser Ile Gly Asp Thr Lys Val Pro Phe Cys 
         275                280                285
Leu Gln Ser Cys Val Lys Pro Leu Lys Tyr Ala Ile Ala Val Asn Asp 
     290                295                300
Leu Gly Thr Glu Tyr Val His Arg Tyr Val Gly Lys Glu Pro Ser Gly 
 305                310                315                320
Leu Arg Phe Asn Lys Leu Phe Leu Asn Glu Asp Asp Lys Pro His Asn 
                 325                330                335
Pro Met Val Asn Ala Gly Ala Ile Val Val Thr Ser Leu Ile Lys Gln 
             340                345                350
Gly Val Asn Asn Ala Glu Lys Phe Asp Tyr Val Met Gln Phe Leu Asn 
         355                360                365
Lys Met Ala Gly Asn Glu Tyr Val Gly Phe Ser Asn Ala Thr Phe Gln 
     370                375                380
Ser Glu Arg Glu Ser Gly Asp Arg Asn Phe Ala Ile Gly Tyr Tyr Leu 
 385                390                395                400
Lys Glu Lys Lys Cys Phe Pro Glu Gly Thr Asp Met Val Gly Ile Leu 
                 405                410                415
Asp Phe Tyr Phe Gln Leu Cys Ser Ile Glu Val Thr Cys Glu Ser Ala 
             420                425                430
Ser Val Met Ala Ala Thr Leu Ala Asn Gly Gly Phe Cys Pro Ile Thr 
         435                440                445
Gly Glu Arg Val Leu Ser Pro Glu Ala Val Arg Asn Thr Leu Ser Leu 
     450                455                460
Met His Ser Cys Gly Met Tyr Asp Phe Ser Gly Gln Phe Ala Phe His 
 465                470                475                480
Val Gly Leu Pro Ala Lys Ser Gly Val Ala Gly Gly Ile Leu Leu Val 
                 485                490                495
Val Pro Asn Val Met Gly Met Met Cys Trp Ser Pro Pro Leu Asp Lys 
             500                505                510
Met Gly Asn Ser Val Lys Gly Ile His Phe Cys His Asp Leu Val Ser 
         515                520                525
Leu Cys Asn Phe His Asn Tyr Asp Asn Leu Arg His Phe Ala Lys Lys 
     530                535                540
Leu Asp Pro Arg Arg Glu Gly Gly Asp Gln Arg Val Lys Ser Val Ile 
 545                550                555                560
Asn Leu Leu Phe Ala Ala Tyr Thr Gly Asp Val Ser Ala Leu Arg Arg 
                 565                570                575
Phe Ala Leu Ser Ala Met Asp Met Glu Gln Arg Asp Tyr Asp Ser Arg 
             580                585                590
Thr Ala Leu His Val Ala Ala Ala Glu Gly His Val Glu Val Val Lys 
         595                600                605
Phe Leu Leu Glu Ala Cys Lys Val Asn Pro Phe Pro Lys Asp Arg Trp 
     610                615                620
Asn Asn Thr Pro Met Asp Glu Ala Leu His Phe Gly His His Asp Val 
 625                630                635                640
Phe Lys Ile Leu Gln Glu Tyr Gln Val Gln Tyr Thr Pro Gln Gly Asp 
                 645                650                655
Ser Asp Asp Gly Lys Glu Asn Gln Thr Val His Lys Asn Leu Asp Gly 
             660                665                670
Leu Leu 
         675



<210> 7024
<211> 2010
<212> DNA
<213> Homo sapiens
<308> AF097495
<400> 7024

cgcgcagca  cagcagcag  agcagcagc  gcagcagca  cagcagcac  cgcatccgc  60
gcgggagtc  gagccggaa  cacacccaa  tagctgccc  ttcctcttc  gtcatctca  120
cgccccacc  cagaccgcg  tccccgagg  aaccggccg  ccacgcccg  agcatcctc  180
cctgttgag  gggcgctga  ggacccggc  gcatgatgc  gctgcgaag  tcggggatg  240
tgcgggacc  gctcctgcg  tcgcccgcc  gcgtgagcg  gactctgcg  cgggcacag  300
ccttggtca  cctgtgccg  cgtccccga  gcgggggac  gccggccgc  ggcncggct  360
ccgccgcgc  actccaccc  tggtggggc  ggggcggct  gccggcgga  cccctcgcg  420
ggggcctgt  cagctctcc  tcggagatc  tgcaggagc  gggcaaggg  agcacgcat  480
cgcagcccg  ggtgtcgcc  cccgctgcc  cggcggcgc  cggccccaa  gacggcccc  540
gggagacgg  cgcgtttgg  aacagcgag  gcaaagagc  ggtggcctc  ggtgaaaat  600
aaataaaac  gggtctgtt  cctagcttg  aagatttgc  gttctatac  attgctgaa  660
gacaagaga  aatacctgt  cataaattt  ttacagtaa  tttttatat  tttctatct  720
aacttaaaa  aatcaataa  aataaatat  tacagtatt  ttgaaatat  gtcttaaag  780
tcgtctgac  tgtagattc  gactgacaa  atttctctt  ttatgtttt  aaatttttg  840
catgctcat  tcaaggtaa  cagtgaaag  aaaagaaag  aacaatgag  aacttgtcc  900
gaaagtggg  aatagtgac  ctaagatgc  atattcatg  tcaagtgtt  ggtagaagt  960
tttatatac  ggaataaaa  cttatagtt  gtataagna  atacattat  tgcactata  1020
atttacaaa  tcttatttt  tttaaaaac  ggcactcaa  tctacagga  tgcgaacgt  1080
tgatcccag  ttgaaagag  gtatggata  gttaagatt  actcttcaa  caacatcag  1140
tggtgtcat  ctagacaaa  atcttttta  aaagtaaaa  tttctgcca  acctttaat  1200
gtgatttgc  atgctatac  gtgattctg  ttttaaaac  aaattgcat  tttgaaggc  1260
actgcttcc  gtgtaatgg  aaaagggga  ttataaaca  catttgttt  aagaacttg  1320
tacatatta  tcataatac  ccgggctaa  agtattctt  ctttaaatc  gttctaagc  1380
aatttagcc  ccgatgttt  cagtttaca  tacttggag  ttgcattca  tttgagtag  1440
gcacatcct  tgtcctgtc  ttgcttata  tgatcccca  ttcatctgc  tgacttgca  1500
gctttctca  catggtctc  agttctttt  cacaaggtg  tttaggtga  atcataaaa  1560
gagagggct  cagacagac  tgtgttcct  acatttaca  acctcgatt  tctgctcct  1620
tcctctctt  agacatatt  atacatagg  ttttggcta  tttcatttt  ttcaaaaca  1680
taaagaact  aaggcaact  tggcgatta  agccttgat  tggttgaat  agaattttt  1740
ctttgatgt  cctgtattt  catatattt  ttatttatc  tcattaatg  gtttctatt  1800
gtttgatta  ttaaagatt  atggacatg  gtgtaatgg  tcccaaaga  tcaaatagt  1860
ttttaaact  ctactattt  agtagaaac  agtataaaa  tgtaaatac  actataaga  1920
attggcttt  tccagacat  gatccgggg  gttctgcat  tacaagaaa  tttgttatg  1980
atggttgta  ttacttttg  tttatcttct  2010



<210> 7025
<211> 669
<212> PRT
<213> Homo sapiens
<308> O94925
<400> 7025

Met Met Arg Leu Arg Gly Ser Gly Met Leu Arg Asp Leu Leu Leu Arg 
  1               5                  10                  15
Ser Pro Ala Gly Val Ser Ala Thr Leu Arg Arg Ala Gln Pro Leu Val 
             20                  25                  30
Thr Leu Cys Arg Arg Pro Arg Gly Gly Gly Arg Pro Ala Ala Gly Pro 
         35                  40                  45
Ala Ala Ala Ala Arg Leu His Pro Trp Trp Gly Gly Gly Gly Trp Pro 
     50                  55                  60
Ala Glu Pro Leu Ala Arg Gly Leu Ser Ser Ser Pro Ser Glu Ile Leu 
 65                  70                  75                  80
Gln Glu Leu Gly Lys Gly Ser Thr His Pro Gln Pro Gly Val Ser Pro 
                 85                  90                  95
Pro Ala Ala Pro Ala Ala Pro Gly Pro Lys Asp Gly Pro Gly Glu Thr 
             100                105                110
Asp Ala Phe Gly Asn Ser Glu Gly Lys Glu Leu Val Ala Ser Gly Glu 
         115                120                125
Asn Lys Ile Lys Gln Gly Leu Leu Pro Ser Leu Glu Asp Leu Leu Phe 
     130                135                140
Tyr Thr Ile Ala Glu Gly Gln Glu Lys Ile Pro Val His Lys Phe Ile 
 145                150                155                160
Thr Ala Leu Lys Ser Thr Gly Leu Arg Thr Ser Asp Pro Arg Leu Lys 
                 165                170                175
Glu Cys Met Asp Met Leu Arg Leu Thr Leu Gln Thr Thr Ser Asp Gly 
             180                185                190
Val Met Leu Asp Lys Asp Leu Phe Lys Lys Cys Val Gln Ser Asn Ile 
         195                200                205
Val Leu Leu Thr Gln Ala Phe Arg Arg Lys Phe Val Ile Pro Asp Phe 
     210                215                220
Met Ser Phe Thr Ser His Ile Asp Glu Leu Tyr Glu Ser Ala Lys Lys 
 225                230                235                240
Gln Ser Gly Gly Lys Val Ala Asp Tyr Ile Pro Gln Leu Ala Lys Phe 
                 245                250                255
Ser Pro Asp Leu Trp Gly Val Ser Val Cys Thr Val Asp Gly Gln Arg 
             260                265                270
His Ser Thr Gly Asp Thr Lys Val Pro Phe Cys Leu Gln Ser Cys Val 
         275                280                285
Lys Pro Leu Lys Tyr Ala Ile Ala Val Asn Asp Leu Gly Thr Glu Tyr 
     290                295                300
Val His Arg Tyr Val Gly Lys Glu Pro Ser Gly Leu Arg Phe Asn Lys 
 305                310                315                320
Leu Phe Leu Asn Glu Asp Asp Lys Pro His Asn Pro Met Val Asn Ala 
                 325                330                335
Gly Ala Ile Val Val Thr Ser Leu Ile Lys Gln Gly Val Asn Asn Ala 
             340                345                350
Glu Lys Phe Asp Tyr Val Met Gln Phe Leu Asn Lys Met Ala Gly Asn 
         355                360                365
Glu Tyr Val Gly Phe Ser Asn Ala Thr Phe Gln Ser Glu Arg Glu Ser 
     370                375                380
Gly Asp Arg Asn Phe Ala Ile Gly Tyr Tyr Leu Lys Glu Lys Lys Cys 
 385                390                395                400
Phe Pro Glu Gly Thr Asp Met Val Gly Ile Leu Asp Phe Tyr Phe Gln 
                 405                410                415
Leu Cys Ser Ile Glu Val Thr Cys Glu Ser Ala Ser Val Met Ala Ala 
             420                425                430
Thr Leu Ala Asn Gly Gly Phe Cys Pro Ile Thr Gly Glu Arg Val Leu 
         435                440                445
Ser Pro Glu Ala Val Arg Asn Thr Leu Ser Leu Met His Ser Cys Gly 
     450                455                460
Met Tyr Asp Phe Ser Gly Gln Phe Ala Phe His Val Gly Leu Pro Ala 
 465                470                475                480
Lys Ser Gly Val Ala Gly Gly Ile Leu Leu Val Val Pro Asn Val Met 
                 485                490                495
Gly Met Met Cys Trp Ser Pro Pro Leu Asp Lys Met Gly Asn Ser Val 
             500                505                510
Lys Gly Ile His Phe Cys His Asp Leu Val Ser Leu Cys Asn Phe His 
         515                520                525
Asn Tyr Asp Asn Leu Arg His Phe Ala Lys Lys Leu Asp Pro Arg Arg 
     530                535                540
Glu Gly Gly Asp Gln Arg Val Lys Ser Val Ile Asn Leu Leu Phe Ala 
 545                550                555                560
Ala Tyr Thr Gly Asp Val Ser Ala Leu Arg Arg Phe Ala Leu Ser Ala 
                 565                570                575
Met Asp Met Glu Gln Arg Asp Tyr Asp Ser Arg Thr Ala Leu His Val 
             580                585                590
Ala Ala Ala Glu Gly His Val Glu Val Val Lys Phe Leu Leu Glu Ala 
         595                600                605
Cys Lys Val Asn Pro Phe Pro Lys Asp Arg Trp Asn Asn Thr Pro Met 
     610                615                620
Asp Glu Ala Leu His Phe Gly His His Asp Val Phe Lys Ile Leu Gln 
 625                630                635                640
Glu Tyr Gln Val Gln Tyr Thr Pro Gln Gly Asp Ser Asp Asn Gly Lys 
                 645                650                655
Glu Asn Gln Thr Val His Lys Asn Leu Asp Gly Leu Leu 
             660                665



<210> 7026
<211> 536
<212> DNA
<213> Rattus norvegicus
<308> AI176589
<400> 7026

aggcagaca  cttgttatt  tttattttt  taatgacga  aacaaaaat  catctaaaa  60
cgaagcttc  ggaaaaacc  tttgttctt  cctgtcttg  atcgctcct  aaacttgac  120
ttggcctcc  gcctggcct  gcgtttcag  gctgggtct  tgaacacat  cttgttgac  180
acagttttg  ccaagggga  atccacaga  taccttgtg  gcatgaggt  gttgtagtt  240
taaactttc  caaaggact  gatcttgga  cgcttggcg  tcttcttct  gcccatggc  300
gctgtcact  ttctgggat  gcggtcaat  ccagccacc  gggcatggc  gtaagggcg  360
tcggaggtg  catcatcaa  gttctttac  atgacggct  tgcgtccgg  gtagcgtcc  420
gccaggacc  gcaccactt  cccgggttt  ataaacttg  ccatttcga  agcgagcag  480
aggcaccca  caaaaagga  agaaggcca  ttccgctaa  ctttcaccc  cgtgcc  536



<210> 7027
<211> 135
<212> PRT
<213> Rattus norvegicus
<308> P08526
<400> 7027

Gly Lys Phe Met Lys Pro Gly Lys Val Val Leu Val Leu Ala Gly Arg 
  1               5                  10                  15
Tyr Ser Gly Arg Lys Ala Val Ile Val Lys Asn Ile Asp Asp Gly Thr 
             20                  25                  30
Ser Asp Arg Pro Tyr Ser His Ala Leu Val Ala Gly Ile Asp Arg Tyr 
         35                  40                  45
Pro Arg Lys Val Thr Ala Ala Met Gly Lys Lys Lys Ile Ala Lys Arg 
     50                  55                  60
Ser Lys Ile Lys Ser Phe Val Lys Val Tyr Asn Tyr Asn His Leu Met 
 65                  70                  75                  80
Pro Thr Arg Tyr Ser Val Asp Ile Pro Leu Asp Lys Thr Val Val Asn 
                 85                  90                  95
Lys Asp Val Phe Arg Asp Pro Ala Leu Lys Arg Lys Ala Arg Arg Glu 
             100                105                110
Ala Lys Val Lys Phe Glu Glu Arg Tyr Lys Thr Gly Lys Asn Lys Trp 
         115                120                125
Phe Phe Gln Lys Leu Arg Phe 
     130                135



<210> 7028
<211> 638
<212> DNA
<213> Homo sapiens
<308> BG939205
<400> 7028

ggcacgagc  ggctcttta  tgggaaatg  gaggaaggg  tgtccgcac  ggaatgggg  60
taggctgtc  gaagcgcag  cccctgcgg  ctaagtcgg  tcgggcctc  tgtatctgg  120
tctgcagct  gcgtgcggc  tcctcgcag  catgaaaag  ggccacacg  tagcccaca  180
tgcccaggg  atagcagcc  gcggacacc  gcaagtagg  gggcagtgg  cacaggact  240
cctggcagg  caagggcag  tccaggccc  aggctcccg  ggtcagggc  acccaggtg  300
agcccagga  cgctagtcc  caaagccac  gcgctaatt  cgtcatggt  actgcgaga  360
aaggaagca  tgctcccct  taccccacg  ctccccttc  ccgcgcggc  cgggtggtt  420
ctgccgaaa  gggcaagtt  atgaaacct  ggaaggtgg  gcttgtcct  gctggacgc  480
actccggac  caaagctgt  atcgtgaag  acattgatg  tggcacctc  gatcgcccc  540
acagccatg  tctggtggc  ggaattgac  gctaccccc  caaagtgac  gctgccatg  600
gcaagaaga  gatcgccaa  agatcaaag  taaaatct  638



<210> 7029
<211> 92
<212> PRT
<213> Homo sapiens
<308> Q9P2X0
<400> 7029

Met Thr Lys Leu Ala Gln Trp Leu Trp Gly Leu Ala Ile Leu Gly Ser 
  1               5                  10                  15
Thr Trp Val Ala Leu Thr Thr Gly Ala Leu Gly Leu Glu Leu Pro Leu 
             20                  25                  30
Ser Cys Gln Glu Val Leu Trp Pro Leu Pro Ala Tyr Leu Leu Val Ser 
         35                  40                  45
Ala Gly Cys Tyr Ala Leu Gly Thr Val Gly Tyr Arg Val Ala Thr Phe 
     50                  55                  60
His Asp Cys Glu Asp Ala Ala Arg Glu Leu Gln Ser Gln Ile Gln Glu 
 65                  70                  75                  80
Ala Arg Ala Asp Leu Ala Arg Arg Gly Val Arg Phe 
                 85                  90



<210> 7030
<211> 536
<212> DNA
<213> Rattus norvegicus
<308> AI176589
<400> 7030

aggcagaca  cttgttatt  tttattttt  taatgacga  aacaaaaat  catctaaaa  60
cgaagcttc  ggaaaaacc  tttgttctt  cctgtcttg  atcgctcct  aaacttgac  120
ttggcctcc  gcctggcct  gcgtttcag  gctgggtct  tgaacacat  cttgttgac  180
acagttttg  ccaagggga  atccacaga  taccttgtg  gcatgaggt  gttgtagtt  240
taaactttc  caaaggact  gatcttgga  cgcttggcg  tcttcttct  gcccatggc  300
gctgtcact  ttctgggat  gcggtcaat  ccagccacc  gggcatggc  gtaagggcg  360
tcggaggtg  catcatcaa  gttctttac  atgacggct  tgcgtccgg  gtagcgtcc  420
gccaggacc  gcaccactt  cccgggttt  ataaacttg  ccatttcga  agcgagcag  480
aggcaccca  caaaaagga  agaaggcca  ttccgctaa  ctttcaccc  cgtgcc  536



<210> 7031
<211> 135
<212> PRT
<213> Rattus norvegicus
<308> P08526
<400> 7031

Gly Lys Phe Met Lys Pro Gly Lys Val Val Leu Val Leu Ala Gly Arg 
  1               5                  10                  15
Tyr Ser Gly Arg Lys Ala Val Ile Val Lys Asn Ile Asp Asp Gly Thr 
             20                  25                  30
Ser Asp Arg Pro Tyr Ser His Ala Leu Val Ala Gly Ile Asp Arg Tyr 
         35                  40                  45
Pro Arg Lys Val Thr Ala Ala Met Gly Lys Lys Lys Ile Ala Lys Arg 
     50                  55                  60
Ser Lys Ile Lys Ser Phe Val Lys Val Tyr Asn Tyr Asn His Leu Met 
 65                  70                  75                  80
Pro Thr Arg Tyr Ser Val Asp Ile Pro Leu Asp Lys Thr Val Val Asn 
                 85                  90                  95
Lys Asp Val Phe Arg Asp Pro Ala Leu Lys Arg Lys Ala Arg Arg Glu 
             100                105                110
Ala Lys Val Lys Phe Glu Glu Arg Tyr Lys Thr Gly Lys Asn Lys Trp 
         115                120                125
Phe Phe Gln Lys Leu Arg Phe 
     130                135



<210> 7032
<211> 638
<212> DNA
<213> Homo sapiens
<308> BG939205
<400> 7032

ggcacgagc  ggctcttta  tgggaaatg  gaggaaggg  tgtccgcac  ggaatgggg  60
taggctgtc  gaagcgcag  cccctgcgg  ctaagtcgg  tcgggcctc  tgtatctgg  120
tctgcagct  gcgtgcggc  tcctcgcag  catgaaaag  ggccacacg  tagcccaca  180
tgcccaggg  atagcagcc  gcggacacc  gcaagtagg  gggcagtgg  cacaggact  240
cctggcagg  caagggcag  tccaggccc  aggctcccg  ggtcagggc  acccaggtg  300
agcccagga  cgctagtcc  caaagccac  gcgctaatt  cgtcatggt  actgcgaga  360
aaggaagca  tgctcccct  taccccacg  ctccccttc  ccgcgcggc  cgggtggtt  420
ctgccgaaa  gggcaagtt  atgaaacct  ggaaggtgg  gcttgtcct  gctggacgc  480
actccggac  caaagctgt  atcgtgaag  acattgatg  tggcacctc  gatcgcccc  540
acagccatg  tctggtggc  ggaattgac  gctaccccc  caaagtgac  gctgccatg  600
gcaagaaga  gatcgccaa  agatcaaag  taaaatct  638



<210> 7033
<211> 92
<212> PRT
<213> Homo sapiens
<308> Q9P2X0
<400> 7033

Met Thr Lys Leu Ala Gln Trp Leu Trp Gly Leu Ala Ile Leu Gly Ser 
  1               5                  10                  15
Thr Trp Val Ala Leu Thr Thr Gly Ala Leu Gly Leu Glu Leu Pro Leu 
             20                  25                  30
Ser Cys Gln Glu Val Leu Trp Pro Leu Pro Ala Tyr Leu Leu Val Ser 
         35                  40                  45
Ala Gly Cys Tyr Ala Leu Gly Thr Val Gly Tyr Arg Val Ala Thr Phe 
     50                  55                  60
His Asp Cys Glu Asp Ala Ala Arg Glu Leu Gln Ser Gln Ile Gln Glu 
 65                  70                  75                  80
Ala Arg Ala Asp Leu Ala Arg Arg Gly Val Arg Phe 
                 85                  90



<210> 7034
<211> 536
<212> DNA
<213> Rattus norvegicus
<308> AI176589
<400> 7034

aggcagaca  cttgttatt  tttattttt  taatgacga  aacaaaaat  catctaaaa  60
cgaagcttc  ggaaaaacc  tttgttctt  cctgtcttg  atcgctcct  aaacttgac  120
ttggcctcc  gcctggcct  gcgtttcag  gctgggtct  tgaacacat  cttgttgac  180
acagttttg  ccaagggga  atccacaga  taccttgtg  gcatgaggt  gttgtagtt  240
taaactttc  caaaggact  gatcttgga  cgcttggcg  tcttcttct  gcccatggc  300
gctgtcact  ttctgggat  gcggtcaat  ccagccacc  gggcatggc  gtaagggcg  360
tcggaggtg  catcatcaa  gttctttac  atgacggct  tgcgtccgg  gtagcgtcc  420
gccaggacc  gcaccactt  cccgggttt  ataaacttg  ccatttcga  agcgagcag  480
aggcaccca  caaaaagga  agaaggcca  ttccgctaa  ctttcaccc  cgtgcc  536



<210> 7035
<211> 135
<212> PRT
<213> Rattus norvegicus
<308> P08526
<400> 7035

Gly Lys Phe Met Lys Pro Gly Lys Val Val Leu Val Leu Ala Gly Arg 
  1               5                  10                  15
Tyr Ser Gly Arg Lys Ala Val Ile Val Lys Asn Ile Asp Asp Gly Thr 
             20                  25                  30
Ser Asp Arg Pro Tyr Ser His Ala Leu Val Ala Gly Ile Asp Arg Tyr 
         35                  40                  45
Pro Arg Lys Val Thr Ala Ala Met Gly Lys Lys Lys Ile Ala Lys Arg 
     50                  55                  60
Ser Lys Ile Lys Ser Phe Val Lys Val Tyr Asn Tyr Asn His Leu Met 
 65                  70                  75                  80
Pro Thr Arg Tyr Ser Val Asp Ile Pro Leu Asp Lys Thr Val Val Asn 
                 85                  90                  95
Lys Asp Val Phe Arg Asp Pro Ala Leu Lys Arg Lys Ala Arg Arg Glu 
             100                105                110
Ala Lys Val Lys Phe Glu Glu Arg Tyr Lys Thr Gly Lys Asn Lys Trp 
         115                120                125
Phe Phe Gln Lys Leu Arg Phe 
     130                135



<210> 7036
<211> 638
<212> DNA
<213> Homo sapiens
<308> BG939205
<400> 7036

ggcacgagc  ggctcttta  tgggaaatg  gaggaaggg  tgtccgcac  ggaatgggg  60
taggctgtc  gaagcgcag  cccctgcgg  ctaagtcgg  tcgggcctc  tgtatctgg  120
tctgcagct  gcgtgcggc  tcctcgcag  catgaaaag  ggccacacg  tagcccaca  180
tgcccaggg  atagcagcc  gcggacacc  gcaagtagg  gggcagtgg  cacaggact  240
cctggcagg  caagggcag  tccaggccc  aggctcccg  ggtcagggc  acccaggtg  300
agcccagga  cgctagtcc  caaagccac  gcgctaatt  cgtcatggt  actgcgaga  360
aaggaagca  tgctcccct  taccccacg  ctccccttc  ccgcgcggc  cgggtggtt  420
ctgccgaaa  gggcaagtt  atgaaacct  ggaaggtgg  gcttgtcct  gctggacgc  480
actccggac  caaagctgt  atcgtgaag  acattgatg  tggcacctc  gatcgcccc  540
acagccatg  tctggtggc  ggaattgac  gctaccccc  caaagtgac  gctgccatg  600
gcaagaaga  gatcgccaa  agatcaaag  taaaatct  638



<210> 7037
<211> 92
<212> PRT
<213> Homo sapiens
<308> Q9P2X0
<400> 7037

Met Thr Lys Leu Ala Gln Trp Leu Trp Gly Leu Ala Ile Leu Gly Ser 
  1               5                  10                  15
Thr Trp Val Ala Leu Thr Thr Gly Ala Leu Gly Leu Glu Leu Pro Leu 
             20                  25                  30
Ser Cys Gln Glu Val Leu Trp Pro Leu Pro Ala Tyr Leu Leu Val Ser 
         35                  40                  45
Ala Gly Cys Tyr Ala Leu Gly Thr Val Gly Tyr Arg Val Ala Thr Phe 
     50                  55                  60
His Asp Cys Glu Asp Ala Ala Arg Glu Leu Gln Ser Gln Ile Gln Glu 
 65                  70                  75                  80
Ala Arg Ala Asp Leu Ala Arg Arg Gly Val Arg Phe 
                 85                  90



<210> 7038
<211> 536
<212> DNA
<213> Rattus norvegicus
<308> AI176589
<400> 7038

aggcagaca  cttgttatt  tttattttt  taatgacga  aacaaaaat  catctaaaa  60
cgaagcttc  ggaaaaacc  tttgttctt  cctgtcttg  atcgctcct  aaacttgac  120
ttggcctcc  gcctggcct  gcgtttcag  gctgggtct  tgaacacat  cttgttgac  180
acagttttg  ccaagggga  atccacaga  taccttgtg  gcatgaggt  gttgtagtt  240
taaactttc  caaaggact  gatcttgga  cgcttggcg  tcttcttct  gcccatggc  300
gctgtcact  ttctgggat  gcggtcaat  ccagccacc  gggcatggc  gtaagggcg  360
tcggaggtg  catcatcaa  gttctttac  atgacggct  tgcgtccgg  gtagcgtcc  420
gccaggacc  gcaccactt  cccgggttt  ataaacttg  ccatttcga  agcgagcag  480
aggcaccca  caaaaagga  agaaggcca  ttccgctaa  ctttcaccc  cgtgcc  536



<210> 7039
<211> 135
<212> PRT
<213> Rattus norvegicus
<308> P08526
<400> 7039

Gly Lys Phe Met Lys Pro Gly Lys Val Val Leu Val Leu Ala Gly Arg 
  1               5                  10                  15
Tyr Ser Gly Arg Lys Ala Val Ile Val Lys Asn Ile Asp Asp Gly Thr 
             20                  25                  30
Ser Asp Arg Pro Tyr Ser His Ala Leu Val Ala Gly Ile Asp Arg Tyr 
         35                  40                  45
Pro Arg Lys Val Thr Ala Ala Met Gly Lys Lys Lys Ile Ala Lys Arg 
     50                  55                  60
Ser Lys Ile Lys Ser Phe Val Lys Val Tyr Asn Tyr Asn His Leu Met 
 65                  70                  75                  80
Pro Thr Arg Tyr Ser Val Asp Ile Pro Leu Asp Lys Thr Val Val Asn 
                 85                  90                  95
Lys Asp Val Phe Arg Asp Pro Ala Leu Lys Arg Lys Ala Arg Arg Glu 
             100                105                110
Ala Lys Val Lys Phe Glu Glu Arg Tyr Lys Thr Gly Lys Asn Lys Trp 
         115                120                125
Phe Phe Gln Lys Leu Arg Phe 
     130                135



<210> 7040
<211> 638
<212> DNA
<213> Homo sapiens
<308> BG939205
<400> 7040

ggcacgagc  ggctcttta  tgggaaatg  gaggaaggg  tgtccgcac  ggaatgggg  60
taggctgtc  gaagcgcag  cccctgcgg  ctaagtcgg  tcgggcctc  tgtatctgg  120
tctgcagct  gcgtgcggc  tcctcgcag  catgaaaag  ggccacacg  tagcccaca  180
tgcccaggg  atagcagcc  gcggacacc  gcaagtagg  gggcagtgg  cacaggact  240
cctggcagg  caagggcag  tccaggccc  aggctcccg  ggtcagggc  acccaggtg  300
agcccagga  cgctagtcc  caaagccac  gcgctaatt  cgtcatggt  actgcgaga  360
aaggaagca  tgctcccct  taccccacg  ctccccttc  ccgcgcggc  cgggtggtt  420
ctgccgaaa  gggcaagtt  atgaaacct  ggaaggtgg  gcttgtcct  gctggacgc  480
actccggac  caaagctgt  atcgtgaag  acattgatg  tggcacctc  gatcgcccc  540
acagccatg  tctggtggc  ggaattgac  gctaccccc  caaagtgac  gctgccatg  600
gcaagaaga  gatcgccaa  agatcaaag  taaaatct  638



<210> 7041
<211> 92
<212> PRT
<213> Homo sapiens
<308> Q9P2X0
<400> 7041

Met Thr Lys Leu Ala Gln Trp Leu Trp Gly Leu Ala Ile Leu Gly Ser 
  1               5                  10                  15
Thr Trp Val Ala Leu Thr Thr Gly Ala Leu Gly Leu Glu Leu Pro Leu 
             20                  25                  30
Ser Cys Gln Glu Val Leu Trp Pro Leu Pro Ala Tyr Leu Leu Val Ser 
         35                  40                  45
Ala Gly Cys Tyr Ala Leu Gly Thr Val Gly Tyr Arg Val Ala Thr Phe 
     50                  55                  60
His Asp Cys Glu Asp Ala Ala Arg Glu Leu Gln Ser Gln Ile Gln Glu 
 65                  70                  75                  80
Ala Arg Ala Asp Leu Ala Arg Arg Gly Val Arg Phe 
                 85                  90



<210> 7042
<211> 603
<212> DNA
<213> Rattus norvegicus
<308> AI176689
<400> 7042

actctttga  ccatgaaac  agtgacttt  agattttcc  acgttgggg  aggtggggt  60
aggagcatt  actttgaca  ttcattcaa  agattcggt  atcacccac  gtggagttg  120
cggtcggga  cagccgcca  gacagccgc  agccacagt  cataggaag  gcccctttg  180
ttgagattt  ttttttata  tattcttaa  gatgcatat  aaataactt  ctctggacc  240
cagacatga  tgaacttaa  aaataaaag  cctataaac  ctgccaagt  agccttgtc  300
ctgtatctc  cttcttgca  aaaaatgga  tatttccaa  caagcactg  aacataaat  360
ttaaaataa  tgggatacg  tacgaacct  ctttacaat  tcgtcaact  ctgtagcac  420
ttgttacca  ggccaatgc  ttcattttg  aaagaacac  agagatccc  gaggcttga  480
gactcctcg  atgcctcgc  attaaatat  ttatcacct  ttcgagtcc  aagcctcta  540
catatttca  ccatataga  agctcaacc  acgctagag  ttccaaggc  cccttcgga  600
agg  603



<210> 7043
<211> 334
<212> PRT
<213> Rattus norvegicus
<308> AAK53428
<400> 7043

Met Ser Gln Ser Lys Gly Lys Lys Arg Asn Pro Gly Leu Lys Ile Pro 
  1               5                  10                  15
Arg Glu Ala Phe Glu Gln Pro Gln Thr Ser Ser Thr Pro Pro Arg Asp 
             20                  25                  30
Leu Asp Ser Lys Ala Cys Ile Ser Ile Gly Asn Gln Asn Phe Glu Val 
         35                  40                  45
Lys Ala Asp Asp Leu Glu Pro Ile Val Glu Leu Gly Arg Gly Ala Tyr 
     50                  55                  60
Gly Val Val Glu Lys Met Arg His Val Pro Ser Gly Gln Ile Met Ala 
 65                  70                  75                  80
Val Lys Arg Ile Arg Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu 
                 85                  90                  95
Leu Met Asp Leu Asp Val Ser Met Arg Thr Val Asp Cys Pro Phe Thr 
             100                105                110
Val Thr Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys 
         115                120                125
Met Glu Leu Met Asp Thr Ser Leu Asp Lys Phe Tyr Lys Gln Val Ile 
     130                135                140
Asp Lys Gly Gln Thr Ile Pro Glu Asp Ile Leu Gly Lys Ile Ala Val 
 145                150                155                160
Ser Ile Val Lys Ala Leu Glu His Leu His Ser Lys Leu Ser Val Ile 
                 165                170                175
His Arg Asp Val Lys Pro Ser Asn Val Leu Ile Asn Thr Leu Gly Gln 
             180                185                190
Val Lys Met Cys Asp Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val 
         195                200                205
Ala Lys Thr Ile Asp Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg 
     210                215                220
Ile Asn Pro Glu Leu Asn Gln Lys Gly Tyr Ser Val Lys Ser Asp Ile 
 225                230                235                240
Trp Ser Leu Gly Ile Thr Met Ile Glu Leu Ala Ile Leu Arg Phe Pro 
                 245                250                255
Tyr Asp Ser Trp Gly Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu 
             260                265                270
Glu Pro Ser Pro Gln Leu Pro Ala Asp Lys Phe Ser Ala Asp Phe Val 
         275                280                285
Asp Phe Thr Ser Gln Cys Leu Lys Lys Asn Ser Lys Glu Arg Pro Thr 
     290                295                300
Tyr Pro Glu Leu Met Gln His Pro Phe Phe Thr Val His Glu Ala Lys 
 305                310                315                320
Ala Ala Asp Val Ala Ser Phe Val Lys Leu Ile Leu Gly Asp 
                 325                330



<210> 7044
<211> 1005
<212> DNA
<213> Homo sapiens
<308> D87905
<400> 7044

atgtctcag  cgaaaggca  gaagcgaaa  cctggcctt  aaattccaa  agaagcatt  60
gaacaacct  agaccagtt  cacaccacc  cgagattta  actccaagg  ttgcatttc  120
attggaaat  agaactttg  ggtgaaggc  gatgacctg  agcctataa  ggaactggg  180
cgaggtgcg  acggggtgg  ggagaagat  cggcacgtg  ccagcgggc  gatcatggc  240
gtgaagcgg  tccgagcca  agtaaatag  caggaacag  aacggctac  gatggattt  300
gatatttcc  tgaggacgg  ggactgtcc  ttcactgtc  ccttttatg  cgcactgtt  360
cgggagggt  atgtgtgga  ctgcatgga  ctcatggat  catcactag  taaattcta  420
aaacaagtt  ttgataaag  ccagacaat  ccagaggac  tcttaggga  aatagcagt  480
tctattgta  aagcattag  acatttaca  agtaagctg  ctgtcattc  cagagacgt  540
aagccttct  atgtactca  caatgctct  ggtcaagtg  agatgtgcg  ttttggaat  600
agtggctac  tggtggact  tgttgctaa  acaattgat  caggttgca  accatacat  660
gcccctgaa  ggataaacc  agagctcaa  cagaaggga  acagtgtga  gtctgacat  720
tggagtctg  gcatcacga  gattgagtt  gccatcctt  gatttccct  tgattcatg  780
ggaactcca  ttcagcagc  caaacaggt  gtagaggag  catcgccac  actcccagc  840
gacaagttc  ctgcagagt  tgttgactt  acctcacag  gcttaaaga  gaattccaa  900
gaacggcct  catacccag  gctaatgca  catccattt  tcaccctac  tgaatccaa  960
ggaacagat  tggcatctt  tgtaaaact  attcttgga  actaa  1005



<210> 7045
<211> 334
<212> PRT
<213> Homo sapiens
<308> P52564
<400> 7045

Met Ser Gln Ser Lys Gly Lys Lys Arg Asn Pro Gly Leu Lys Ile Pro 
  1               5                  10                  15
Lys Glu Ala Phe Glu Gln Pro Gln Thr Ser Ser Thr Pro Pro Arg Asp 
             20                  25                  30
Leu Asp Ser Lys Ala Cys Ile Ser Ile Gly Asn Gln Asn Phe Glu Val 
         35                  40                  45
Lys Ala Asp Asp Leu Glu Pro Ile Met Glu Leu Gly Arg Gly Ala Tyr 
     50                  55                  60
Gly Val Val Glu Lys Met Arg His Val Pro Ser Gly Gln Ile Met Ala 
 65                  70                  75                  80
Val Lys Arg Ile Arg Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu 
                 85                  90                  95
Leu Met Asp Leu Asp Ile Ser Met Arg Thr Val Asp Cys Pro Phe Thr 
             100                105                110
Val Thr Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys 
         115                120                125
Met Glu Leu Met Asp Thr Ser Leu Asp Lys Phe Tyr Lys Gln Val Ile 
     130                135                140
Asp Lys Gly Gln Thr Ile Pro Glu Asp Ile Leu Gly Lys Ile Ala Val 
 145                150                155                160
Ser Ile Val Lys Ala Leu Glu His Leu His Ser Lys Leu Ser Val Ile 
                 165                170                175
His Arg Asp Val Lys Pro Ser Asn Val Leu Ile Asn Ala Leu Gly Gln 
             180                185                190
Val Lys Met Cys Asp Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val 
         195                200                205
Ala Lys Thr Ile Asp Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg 
     210                215                220
Ile Asn Pro Glu Leu Asn Gln Lys Gly Tyr Ser Val Lys Ser Asp Ile 
 225                230                235                240
Trp Ser Leu Gly Ile Thr Met Ile Glu Leu Ala Ile Leu Arg Phe Pro 
                 245                250                255
Tyr Asp Ser Trp Gly Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu 
             260                265                270
Glu Pro Ser Pro Gln Leu Pro Ala Asp Lys Phe Ser Ala Glu Phe Val 
         275                280                285
Asp Phe Thr Ser Gln Cys Leu Lys Lys Asn Ser Lys Glu Arg Pro Thr 
     290                295                300
Tyr Pro Glu Leu Met Gln His Pro Phe Phe Thr Leu His Glu Ser Lys 
 305                310                315                320
Gly Thr Asp Val Ala Ser Phe Val Lys Leu Ile Leu Gly Asp 
                 325                330



<210> 7046
<211> 666
<212> DNA
<213> Rattus norvegicus
<308> AI176856
<400> 7046

atgacagtg  tctttattg  ttaggtgac  ctgtttcat  atagacagt  aagacagag  60
atgttaaat  ttggtatat  acattagtt  attctgtgt  cagaggatc  gtgtgcact  120
tatcagcta  atacagatt  agaacatac  tgacaaagt  caaaagcac  agaagaggt  180
aaataggga  ttatttctg  gttataatc  cctggtaac  tacaccttc  gtcacacaa  240
tgtgtcact  ctaaaaaca  taattagca  acatggtga  gatctctat  taatctagc  300
cagccctgg  gtgaataca  aagggcatg  taatatttc  caggtacag  ctaagttct  360
gggcatgaa  tcttttgag  aattcataa  acacacctg  ggcatattt  ttgtttttg  420
aaaaaaaaa  caacgttct  acatagtcc  agctttact  tgcaaggga  acatttaat  480
aaaacatac  tttgctgcc  tgacaggag  tggatactc  gatgaagat  gtgaccagc  540
aaagaaatc  ctctgtagc  gaataaggc  ggctttcca  ctaagccag  aatctatta  600
cttccgaat  tgacaatng  tactctttc  tgacttgaa  cctccttcc  ttcactggg  660
tctaaa  666



<210> 7047
<211> 543
<212> PRT
<213> Rattus norvegicus
<308> Q64678
<400> 7047

Met Ala Thr Ser Leu Ser Ala Asp Ser Pro Gln Gln Leu Ser Ser Leu 
  1               5                  10                  15
Ser Thr Gln Gln Thr Ile Leu Leu Leu Leu Val Ser Val Leu Ala Ile 
             20                  25                  30
Val His Leu Gly Gln Trp Leu Leu Arg Gln Trp Arg Arg Lys Pro Trp 
         35                  40                  45
Ser Ser Pro Pro Gly Pro Phe Pro Trp Pro Leu Ile Gly Asn Ala Ala 
     50                  55                  60
Ser Val Gly Arg Ala Ser His Leu Tyr Phe Ala Arg Leu Ala Arg Arg 
 65                  70                  75                  80
Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Val Val Val 
                 85                  90                  95
Leu Asn Gly Glu Ser Ala Ile His Gln Ala Leu Val Gln Gln Gly Gly 
             100                105                110
Val Phe Ala Asp Arg Pro Pro Phe Ala Ser Phe Arg Val Val Ser Gly 
         115                120                125
Gly Arg Ser Leu Ala Phe Gly His Tyr Ser Glu Arg Trp Lys Glu Arg 
     130                135                140
Arg Arg Ala Ala Tyr Gly Thr Met Arg Ala Phe Ser Thr Arg His Pro 
 145                150                155                160
Arg Ser Arg Gly Leu Leu Glu Gly His Ala Leu Gly Glu Ala Arg Glu 
                 165                170                175
Leu Val Ala Val Leu Val Arg Arg Cys Ala Gly Gly Ala Cys Leu Asp 
             180                185                190
Pro Thr Gln Pro Ile Ile Val Ala Val Ala Asn Val Met Ser Ala Val 
         195                200                205
Cys Phe Gly Cys Arg Tyr Asn His Asp Asp Ala Glu Phe Leu Glu Leu 
     210                215                220
Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
 225                230                235                240
Val Asp Val Met Pro Trp Leu Gln Leu Phe Pro Asn Pro Val Arg Thr 
                 245                250                255
Ile Phe Arg Glu Phe Glu Gln Ile Asn Arg Asn Phe Ser Asn Phe Val 
             260                265                270
Leu Asp Lys Phe Leu Arg His Arg Glu Ser Leu Val Pro Gly Ala Ala 
         275                280                285
Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
     290                295                300
Thr Gly Asp Pro Gly Asp Ser Pro Ser Gly Leu Asp Leu Glu Asp Val 
 305                310                315                320
Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                 325                330                335
Thr Ala Leu Leu Trp Leu Leu Ile Leu Phe Thr Arg Tyr Pro Asp Val 
             340                345                350
Gln Ala Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
         355                360                365
Leu Pro Cys Met Ser Asp Gln Pro Asn Leu Pro Tyr Val Met Ala Phe 
     370                375                380
Leu Tyr Glu Ser Met Arg Phe Thr Ser Phe Leu Pro Val Thr Leu Pro 
 385                390                395                400
His Ala Thr Thr Ala Asn Thr Phe Val Leu Gly Tyr Tyr Ile Pro Lys 
                 405                410                415
Asn Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Ala 
             420                425                430
Lys Trp Ser Asn Pro Glu Asp Phe Asp Pro Ala Arg Phe Leu Asp Lys 
         435                440                445
Asp Gly Phe Ile Asn Lys Ala Leu Ala Ser Ser Val Met Ile Phe Ser 
     450                455                460
Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Thr Leu Leu 
 465                470                475                480
Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asn Phe Lys Ala Asn 
                 485                490                495
Gln Asn Glu Pro Ser Asn Met Ser Phe Ser Tyr Gly Leu Ser Ile Lys 
             500                505                510
Pro Lys Ser Phe Lys Ile His Val Ser Leu Arg Glu Ser Met Lys Leu 
         515                520                525
Leu Asp Ser Ala Val Glu Lys Leu Gln Ala Glu Glu Ala Cys Gln 
     530                535                540



<210> 7048
<211> 5102
<212> DNA
<213> Homo sapiens
<308> U03688
<400> 7048

gcttctgcg  ctccagttg  gagagccgc  agggcatgg  aattgacgc  actcaccga  60
ccccagtct  aatctcaac  ctgtgagga  acctcgact  tgccaggtc  ccaagggca  120
cggggctcg  cgagcgagg  acccttctc  gtccccatc  caatccaag  gctcctggc  180
ctgacgacg  caagagact  gagtgggag  taaagcttc  agtgagggc  gcaggtgtc  240
aggccgggc  tgcgggttc  tgttgacgt  ttgccctag  caaaggtcc  agttccttc  300
cggagccgg  tgtcccgcg  cactggaaa  cgcacctcc  cgcagcatg  gcaccagcc  360
cagcccgaa  gacccttgg  cgctaaacc  gctgtccat  cagcagacc  cgctcctgc  420
actcctgtc  gtgctggcc  ctgtgcatg  gggccagcg  ctgctgagg  aacggaggc  480
gcagctccg  tccgcgccc  cgggcccgt  tgcgtggcc  ctgatcgga  acgcggcgg  540
ggtgggcca  gcggctcac  tctcgttcg  tcgcctggc  cggcgctac  gcgacgttt  600
ccagatccg  ctgggcagc  gccccatag  ggtgctgaa  ggcgagcgc  ccatccacc  660
ggccctggt  cagcagggc  cggccttcg  cgaccggcc  gccttcgcc  ccttccgtg  720
ggtgtccgg  ggccgcagc  tggctttcg  ccactactc  gagcactgg  aggtgcagc  780
gcgcgcagc  cacagcatg  tgcgcaact  cttcacgcg  cagccgcgc  gccgccaag  840
cctcgaggg  cacgtgctg  gcgaggcgc  cgagctggt  gcgctgctg  tgcgcggca  900
cgcggacgg  gccttcctc  acccgaggc  gctgaccgt  gtggccgtg  ccaacgtca  960
gagtgccgt  tgtttcggc  gccgctaca  ccacgacga  cccgagttc  gtgagctgc  1020
cagccacaa  gaagagttc  ggcgcacgg  gggcgcggg  agcctggtg  acgtgatgc  1080
ctggctgca  tacttcccc  acccggtgc  caccgtttt  cgcgaattc  agcagctca  1140
ccgcaactt  agcaacttc  tcctggaca  gttcttgag  cactgcgaa  gccttcggc  1200
cggggccgc  ccccgcgac  tgatggacg  ctttatcct  tctgcggaa  agaaggcgg  1260
cggggactc  cacggtggt  gcgcgcggc  ggatttgga  aacgtaccg  ccactatca  1320
tgacatctt  ggcgccagc  aggacaccc  gtccaccgc  ctgcagtgg  tgctcctcc  1380
cttcaccag  tatcctgat  tgcagactc  agtgcaggc  gaattggat  aggtcgtgg  1440
gagggaccg  ctgccttgt  tgggtgacc  gcccaacct  ccctatgtc  tggccttcc  1500
ttatgaagc  atgcgcttc  ccagctttg  gcctgtcac  attcctcat  ccaccactg  1560
caacacctc  gtcttgggc  accacattc  caaggacac  gtggttttt  tcaaccagt  1620
gtctgtgaa  catgaccca  tgaagtggc  taacccgga  aactttgat  cagctcgat  1680
cttggacaa  gatggcctc  tcaacaagg  cctgaccag  agagtgatg  ttttttcag  1740
gggcaaaag  cggtgcatt  gcgaagaac  ttctaagat  cagcttttt  tcttcatct  1800
catcctggc  caccagtgc  atttcaggg  caacccaaa  gagcctgcg  aaatgaatt  1860
cagttatgg  ctaaccatt  aacccaagt  atttaaagt  aatgtcact  tcagagagt  1920
catggagct  cttgatagt  ctgtccaaa  tttacaagc  aaggaaact  gccaataag  1980
agcaagagg  aagctgaaa  tttagaaat  ttcacatct  cggagatga  gagtaaaat  2040
cagtttttt  ccagttcct  ttttgtgct  cttctcaat  agcgtttaa  gtgagcata  2100
atcaactgt  catcaggtg  ggtgtgctc  atacccagc  gttcttcat  agtagtggg  2160
tatgcagga  cttctggga  atttttttg  gtcaaagac  taaagggcc  aatgaatta  2220
tatatacat  ctgcatctt  gttatttct  aaggtagca  tctttggag  taaaatgca  2280
atatagaca  atacaccca  acacttaca  caaactact  aatgaagaa  tattttggt  2340
accaggcca  ttttggtgg  aatccaaga  tggtctccc  tatgcagaa  tagacaaaa  2400
gtatattaa  caaagtttc  gagtatatt  ttgaagaga  agagacaag  aatttcagt  2460
taaagtgtg  gattgaagg  gataaggga  aagataaag  ccagaaatt  ccttttcac  2520
ttttcagga  aataactta  actctagta  ttatgggtg  atttatcct  ttgccttct  2580
gtatacttc  ttactttta  ggataaatc  taaagtcag  tgctcaaaa  gaaatcaat  2640
gttgaatta  tgagtatag  ggggttcca  gagttatca  gaattttaa  gtatgcatt  2700
ttaaattgt  aaactccaa  gtgatgttg  acctctttt  cttgccaaa  tacagaatt  2760
gaattatca  caaagaaaa  aaaaaaagc  agccaagct  taaattatg  gaccataat  2820
tactgattt  agtaagtct  ataggttaa  aaaaaaagt  accaaatag  gtgaaatat  2880
ttacttaac  gtccgtaag  agtatatta  tattatctt  ttcaggaaa  ggttgaata  2940
tatatgcct  gtgtaatat  gaaaattga  aagtacaac  aacgcaacc  agtgtgcta  3000
aaatgagct  gattaaatc  accacctat  tttgacatg  aaatgaagc  gggtttctt  3060
tcttcactc  aattttggc  aatctcaaa  ttagatcct  agatgtgtt  ttattttta  3120
aacatcttt  ttgaaattc  atttataat  cagaatctt  ttttgaaaa  aacctaatt  3180
atatattaa  attccaaat  catggcatg  ttaaatttt  actaaattt  aaagccatt  3240
tgattattg  gttccagtt  aagttagtg  aaatctgaa  attctcctg  ggaaggcag  3300
gaaatctaa  ctgtgtctg  ccaatgaat  atggaaaat  ccatgaatt  cctggatgt  3360
ctttttacg  ggtgacaag  gttggggac  gaactccca  tacaactga  caagtttct  3420
ttctagatg  ttttttgaa  gttaacatt  atgcctgct  tttggaaag  cagaatcag  3480
agatagtct  ggaagctgt  tggaaaaga  agtggagat  aggtcagtt  tgtttttta  3540
gatggcaat  actttggta  ctgggaaag  ataaagctc  aatgaaatg  atgcattca  3600
atttagaaa  gtgaattga  gtttcaagt  ttaaagttc  ttgcaatta  acttccaaa  3660
aaagttcta  agtgtccta  gtgctaagt  cttattaca  tttattaag  tttttggaa  3720
ctttgtacc  aaattttaa  aaagggagt  tttgatagt  gtgtgtatg  gtgtgtggg  3780
tggggggat  gtaagagaa  agagagaaa  actgaaaag  aggaaagat  gttaaacat  3840
ttcccactc  ttctgaatt  attaatttg  agcacaaaa  tcaaagcat  gacatttag  3900
agaaagatg  ttggcgtag  agagttaaa  ctcaaatag  ctattaaaa  agtctacaa  3960
atagcagat  tgttttgtg  tttggaata  taaaaaact  catgtaatt  tattttaaa  4020
tttcatagc  gtacttctt  aatataaaa  atcatgcca  tatttttaa  ggcattaga  4080
tcaactaca  aaagcaggc  tgcccagta  atttaaatt  tttggcact  gccattcca  4140
aatattatg  cccaccaag  ctgagacag  gaatttggg  tgctgtagc  tattttttt  4200
gattgagaa  tgtgtagct  caaaaataa  catgaacca  tctggatgc  tcattatgt  4260
aaccaggtc  agatgtgct  taatctgtt  ttacgtatg  aggcccagt  gtcatcaga  4320
gcttgcggc  aaagaaagc  gtgtttata  ggaagaaag  aaggtgctt  gagtttacc  4380
ggcttattt  atatgctta  aacctagtt  aagaaagga  aagaaaaca  aaaacgaat  4440
aaaataact  aatttggag  ctggagtaa  cagattact  ctttaatca  aaaccctca  4500
tgtgtttct  ccggagaga  aatgtattt  ctgacaacc  ttaaagtca  aagttttac  4560
ccaggttat  gcaataaag  ataatgttt  ttaaatgct  catttgtat  tcaaagctt  4620
gactctata  gcaaattgc  tttttccaa  acaaaaaga  gtctcaggt  tgttttgtg  4680
attttctaa  agctttcat  tcccagaac  tagccttta  ctgtgaagt  ttactacag  4740
cttaatatt  tcctagtag  tctatatta  atcaaatag  tgcatagca  tatatgtta  4800
tttgtgtgt  tttagctgt  acacaactg  gtgattaaa  ggtatactt  agtagacat  4860
tataactca  ggatacctt  ttatttaat  ttttcttat  tttgtactt  atcatgaat  4920
cttttagtg  gtgcataat  gctacagtg  atagttgta  acaaagtac  ttctgggga  4980
acaacattt  tatgtagcc  ttactgttt  atataccaa  ttaaaaaaa  attgtatct  5040
attacttat  ctgggacac  attaccaaa  taataaaaa  cactttcat  atcttgaaa  5100
aa  5102



<210> 7049
<211> 543
<212> PRT
<213> Homo sapiens
<308> Q16678
<400> 7049

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
  1               5                  10                  15
Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
             20                  25                  30
Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
         35                  40                  45
Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
     50                  55                  60
Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
 65                  70                  75                  80
Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                 85                  90                  95
Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
             100                105                110
Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
         115                120                125
Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
     130                135                140
Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
 145                150                155                160
Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                 165                170                175
Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
             180                185                190
Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
         195                200                205
Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
     210                215                220
Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
 225                230                235                240
Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                 245                250                255
Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
             260                265                270
Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
         275                280                285
Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
     290                295                300
Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
 305                310                315                320
Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                 325                330                335
Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
             340                345                350
Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
         355                360                365
Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
     370                375                380
Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
 385                390                395                400
His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                 405                410                415
Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Val 
             420                425                430
Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
         435                440                445
Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
     450                455                460
Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
 465                470                475                480
Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                 485                490                495
Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
             500                505                510
Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
         515                520                525
Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
     530                535                540



<210> 7050
<211> 332
<212> DNA
<213> Rattus norvegicus
<308> AI177004
<400> 7050

atgtgtagg  gggaattcc  tttggctaa  caaactttg  gaaaaccta  gttaaattt  60
ctaattttt  attgaacca  ttaaaaaaa  caaacaaaa  ccaaaaaat  cccaaaccc  120
aaagggaaa  aggggtctg  tgagtttga  ctgtcaagt  tataacctg  gtctgtaac  180
ctgtaacct  atagtgccc  gcccatccc  cctacttta  actttatcc  ccaggtaag  240
ggctcagca  cacagcaag  ttccgtgca  cagctccac  ggatttcaa  gcaactgag  300
agcagtcac  ggcccctgg  caaaaagtt  cc  332



<210> 7051
<211> 520
<212> PRT
<213> Rattus norvegicus
<308> P17425
<400> 7051

Met Pro Gly Ser Leu Pro Leu Asn Ala Glu Ala Cys Trp Pro Lys Asp 
  1               5                  10                  15
Val Gly Ile Val Ala Leu Glu Ile Tyr Phe Pro Ser Gln Tyr Val Asp 
             20                  25                  30
Gln Ala Glu Leu Glu Lys Tyr Asp Gly Val Asp Ala Gly Lys Tyr Thr 
         35                  40                  45
Ile Gly Leu Gly Gln Ala Arg Met Gly Phe Cys Thr Asp Arg Glu Asp 
     50                  55                  60
Ile Asn Ser Leu Cys Leu Thr Val Val Gln Lys Leu Met Glu Arg Asn 
 65                  70                  75                  80
Ser Leu Ser Tyr Asp Cys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr 
                 85                  90                  95
Ile Ile Asp Lys Ser Lys Ser Val Lys Ser Asn Leu Met Gln Leu Phe 
             100                105                110
Glu Glu Ser Gly Asn Thr Asp Ile Glu Gly Ile Asp Thr Thr Asn Ala 
         115                120                125
Cys Tyr Gly Gly Thr Ala Ala Val Phe Asn Ala Val Asn Trp Ile Glu 
     130                135                140
Ser Ser Ser Trp Asp Gly Arg Tyr Ala Leu Val Val Ala Gly Asp Ile 
 145                150                155                160
Ala Ile Tyr Ala Ser Gly Asn Ala Arg Pro Thr Gly Gly Val Gly Ala 
                 165                170                175
Val Ala Leu Leu Ile Gly Pro Asn Ala Pro Val Ile Phe Asp Arg Gly 
             180                185                190
Leu Arg Gly Thr His Met Gln His Ala Tyr Asp Phe Tyr Lys Pro Asp 
         195                200                205
Met Leu Ser Glu Tyr Pro Val Val Asp Gly Lys Leu Ser Ile Gln Cys 
     210                215                220
Tyr Leu Ser Ala Leu Asp Arg Cys Tyr Ser Val Tyr Arg Lys Lys Ile 
 225                230                235                240
Arg Ala Gln Trp Gln Lys Glu Gly Lys Asp Lys Asp Phe Thr Leu Asn 
                 245                250                255
Asp Phe Gly Phe Met Ile Phe His Ser Pro Tyr Cys Lys Leu Val Gln 
             260                265                270
Lys Ser Leu Ala Arg Met Phe Leu Asn Asp Phe Leu Asn Asp Gln Asn 
         275                280                285
Arg Asp Lys Asn Ser Ile Tyr Ser Gly Leu Glu Ala Phe Gly Asp Val 
     290                295                300
Lys Leu Glu Asp Thr Tyr Phe Asp Arg Asp Val Glu Lys Ala Phe Met 
 305                310                315                320
Lys Ala Ser Ala Glu Leu Phe Asn Gln Lys Thr Lys Ala Ser Leu Leu 
                 325                330                335
Val Ser Asn Gln Asn Gly Asn Met Tyr Thr Ser Ser Val Tyr Gly Ser 
             340                345                350
Leu Ala Ser Val Leu Ala Gln Tyr Ser Pro Gln Gln Leu Ala Gly Lys 
         355                360                365
Arg Ile Gly Val Phe Ser Tyr Gly Ser Gly Leu Ala Ala Thr Leu Tyr 
     370                375                380
Ser Leu Lys Val Thr Gln Asp Ala Thr Pro Gly Ser Ala Leu Asp Lys 
 385                390                395                400
Ile Thr Ala Ser Leu Cys Asp Leu Lys Ser Arg Leu Asp Ser Arg Thr 
                 405                410                415
Cys Val Ala Pro Asp Val Phe Ala Glu Asn Met Lys Leu Arg Glu Asp 
             420                425                430
Thr His His Leu Ala Asn Tyr Ile Pro Gln Cys Ser Ile Asp Ser Leu 
         435                440                445
Phe Glu Gly Thr Trp Tyr Leu Val Arg Val Asp Glu Lys His Arg Arg 
     450                455                460
Thr Tyr Ala Arg Arg Pro Ser Thr Asn Asp His Ser Leu Asp Glu Gly 
 465                470                475                480
Val Gly Leu Val His Ser Asn Thr Ala Thr Glu His Ile Pro Ser Pro 
                 485                490                495
Ala Lys Lys Val Pro Arg Leu Pro Ala Thr Ser Gly Glu Pro Glu Ser 
             500                505                510
Ala Val Ile Ser Asn Gly Glu His 
         515                520



<210> 7052
<211> 2077
<212> DNA
<213> Homo sapiens
<308> BC000297
<400> 7052

ggcacgagg  actcccttt  ctctgctgc  gctcggtca  gcttgtgcc  gaaggagga  60
acagtgaca  acctggaga  tgcagttct  tatccttca  acagctctt  caccatgcc  120
ggatcactt  ctttgaatg  agaagcttg  tggccaaaa  atgtgggaa  tgttgccct  180
gagatctat  ttccttctc  atatgttga  caagcagag  tggaaaaat  tgatggtgt  240
gatgctgga  agtatacca  tggcttggg  caggccaag  tgggcttct  cacagatag  300
gaagatatt  actctcttt  catgactgt  gttcagaat  ttatggaga  aaataacct  360
tcctatgat  gcattgggc  gctggaagt  ggaacagag  caatcatcg  caaatcaaa  420
tctgtgaag  ctaatttga  gcagctgtt  gaagagtct  ggaatacag  tatagaagg  480
atcgacaca  ctaatgcat  ctatggagg  acagctgct  tcttcaatg  tgttaactg  540
attgagtcc  gctcttggg  tggacggta  gccctggta  ttgcaggag  tattgctgt  600
tatgccaca  gaaatgcta  acctacagg  ggagttgga  cagtagctc  gctaattgg  660
ccaaatgct  ctttaattt  tgaacgagg  cttcgtggg  cacatatgc  acatgccta  720
gatttttac  agcctgata  gctatctga  tatcctata  tagatggaa  actctccat  780
cagtgctac  tcagtgcat  agaccgctg  tactctgtc  actgcaaaa  gatccatgc  840
cagtggcag  aagagggaa  tgataaaga  tttaccttg  atgattttg  cttcatgat  900
tttcactca  catattgta  actggttca  aaatctcta  ctcggatgt  gctgaatga  960
ttccttaat  accagaata  agataaaaa  agtatctat  gtggcctgg  agcctttgg  1020
gatgttaaa  tagaagaca  ctactttga  agagatgtg  agaaggcat  tatgaaggc  1080
agctctgaa  tcttcagtc  gaaaacaaa  gcatcttta  ttgtatcaa  tcaaaatgg  1140
aatatgtac  catcttcag  atatggttc  cttgcatct  ttctagcac  gtactcacc  1200
cagcaatta  cagggaaga  aattggagt  ttttcttat  gttctggtt  ggctgccac  1260
ctgtactct  ttaaagtca  acaagatgc  acaccgggg  ctgctcttg  taaaataac  1320
gcaagttta  gtgatctta  atcaaggct  gattcaaga  ctggtgtgg  accagatgt  1380
ttcgctgaa  acatgaagc  cagagagga  acccatcat  tggtcaact  tattcccca  1440
ggttcaata  attcactct  tgaaggaac  tggtactta  ttagggtgg  tgaaaagca  1500
agaagaact  acgctcggc  tcccactcc  aatgatgac  ctttggatg  aggagtagg  1560
cttgtgcat  caaacatag  aactgagca  attccaagc  ctgccaaga  agtaccaag  1620
ctccctgcc  cagcagcag  acctgaagc  gctgtcatt  gtaatgggg  acattaaga  1680
actctgtga  gtgcaagac  tcagggtgg  gtgggcatg  ggtgggggt  tgggaacag  1740
tggaggaat  ggatatctg  ggataattt  aaaggatta  atgttatgt  aatttttat  1800
tgactgaca  ggagcctgg  tgactatcg  gtacttggg  aagtctctt  gctctattt  1860
ctgacatgc  tcctgttgt  gtctggcca  tgccaaatg  actcgaatg  tgttaaggg  1920
tctgtaaaa  ttcatacct  tttggccat  tgtatgcat  atgtttggt  tttaaacat  1980
gtataatga  ttgtgtact  ctgtcagaa  aaagcagag  tactaatct  caattaaaa  2040
attttttaa  atgtaaaaa  aaaaaaaaa  aaaaaaa  2077



<210> 7053
<211> 520
<212> PRT
<213> Homo sapiens
<308> Q01581
<400> 7053

Met Pro Gly Ser Leu Pro Leu Asn Ala Glu Ala Cys Trp Pro Lys Asp 
  1               5                  10                  15
Val Gly Ile Val Ala Leu Glu Ile Tyr Phe Pro Ser Gln Tyr Val Asp 
             20                  25                  30
Gln Ala Glu Leu Glu Lys Tyr Asp Gly Val Asp Ala Gly Lys Tyr Thr 
         35                  40                  45
Ile Gly Leu Gly Gln Ala Lys Met Gly Phe Cys Thr Asp Arg Glu Asp 
     50                  55                  60
Ile Asn Ser Leu Cys Met Thr Val Val Gln Asn Leu Met Glu Arg Asn 
 65                  70                  75                  80
Asn Leu Ser Tyr Asp Cys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr 
                 85                  90                  95
Ile Ile Asp Lys Ser Lys Ser Val Lys Thr Asn Leu Met Gln Leu Phe 
             100                105                110
Glu Glu Ser Gly Asn Thr Asp Ile Glu Gly Ile Asp Thr Thr Asn Ala 
         115                120                125
Cys Tyr Gly Gly Thr Ala Ala Val Phe Asn Ala Val Asn Trp Ile Glu 
     130                135                140
Ser Ser Ser Trp Asp Gly Arg Tyr Ala Leu Val Val Ala Gly Asp Ile 
 145                150                155                160
Ala Val Tyr Ala Thr Gly Asn Ala Arg Pro Thr Gly Gly Val Gly Ala 
                 165                170                175
Val Ala Leu Leu Ile Gly Pro Asn Ala Pro Leu Ile Phe Glu Arg Gly 
             180                185                190
Leu Arg Gly Thr His Met Gln His Ala Tyr Asp Phe Tyr Lys Pro Asp 
         195                200                205
Met Leu Ser Glu Tyr Pro Ile Val Asp Gly Lys Leu Ser Ile Gln Cys 
     210                215                220
Tyr Leu Ser Ala Leu Asp Arg Cys Tyr Ser Val Tyr Cys Lys Lys Ile 
 225                230                235                240
His Ala Gln Trp Gln Lys Glu Gly Asn Asp Lys Asp Phe Thr Leu Asn 
                 245                250                255
Asp Phe Gly Phe Met Ile Phe His Ser Pro Tyr Cys Lys Leu Val Gln 
             260                265                270
Lys Ser Leu Ala Arg Met Leu Leu Asn Asp Phe Leu Asn Asp Gln Asn 
         275                280                285
Arg Asp Lys Asn Ser Ile Tyr Ser Gly Leu Glu Ala Phe Gly Asp Val 
     290                295                300
Lys Leu Glu Asp Thr Tyr Phe Asp Arg Asp Val Glu Lys Ala Phe Met 
 305                310                315                320
Lys Ala Ser Ser Glu Leu Phe Ser Gln Lys Thr Lys Ala Ser Leu Leu 
                 325                330                335
Val Ser Asn Gln Asn Gly Asn Met Tyr Thr Ser Ser Val Tyr Gly Ser 
             340                345                350
Leu Ala Ser Val Leu Ala Gln Tyr Ser Pro Gln Gln Leu Ala Gly Lys 
         355                360                365
Arg Ile Gly Val Phe Ser Tyr Gly Ser Gly Leu Ala Ala Thr Leu Tyr 
     370                375                380
Ser Leu Lys Val Thr Gln Asp Ala Thr Pro Gly Ser Ala Leu Asp Lys 
 385                390                395                400
Ile Thr Ala Ser Leu Cys Asp Leu Lys Ser Arg Leu Asp Ser Arg Thr 
                 405                410                415
Gly Val Ala Pro Asp Val Phe Ala Glu Asn Met Lys Leu Arg Glu Asp 
             420                425                430
Thr His His Leu Val Asn Tyr Ile Pro Gln Gly Ser Ile Asp Ser Leu 
         435                440                445
Phe Glu Gly Thr Trp Tyr Leu Val Arg Val Asp Glu Lys His Arg Arg 
     450                455                460
Thr Tyr Ala Arg Arg Pro Thr Pro Asn Asp Asp Thr Leu Asp Glu Gly 
 465                470                475                480
Val Gly Leu Val His Ser Asn Ile Ala Thr Glu His Ile Pro Ser Pro 
                 485                490                495
Ala Lys Lys Val Pro Arg Leu Pro Ala Thr Ala Ala Glu Pro Glu Ala 
             500                505                510
Ala Val Ile Ser Asn Gly Glu His 
         515                520



<210> 7054
<211> 332
<212> DNA
<213> Rattus norvegicus
<308> AI177004
<400> 7054

atgtgtagg  gggaattcc  tttggctaa  caaactttg  gaaaaccta  gttaaattt  60
ctaattttt  attgaacca  ttaaaaaaa  caaacaaaa  ccaaaaaat  cccaaaccc  120
aaagggaaa  aggggtctg  tgagtttga  ctgtcaagt  tataacctg  gtctgtaac  180
ctgtaacct  atagtgccc  gcccatccc  cctacttta  actttatcc  ccaggtaag  240
ggctcagca  cacagcaag  ttccgtgca  cagctccac  ggatttcaa  gcaactgag  300
agcagtcac  ggcccctgg  caaaaagtt  cc  332



<210> 7055
<211> 520
<212> PRT
<213> Rattus norvegicus
<308> P17425
<400> 7055

Met Pro Gly Ser Leu Pro Leu Asn Ala Glu Ala Cys Trp Pro Lys Asp 
  1               5                  10                  15
Val Gly Ile Val Ala Leu Glu Ile Tyr Phe Pro Ser Gln Tyr Val Asp 
             20                  25                  30
Gln Ala Glu Leu Glu Lys Tyr Asp Gly Val Asp Ala Gly Lys Tyr Thr 
         35                  40                  45
Ile Gly Leu Gly Gln Ala Arg Met Gly Phe Cys Thr Asp Arg Glu Asp 
     50                  55                  60
Ile Asn Ser Leu Cys Leu Thr Val Val Gln Lys Leu Met Glu Arg Asn 
 65                  70                  75                  80
Ser Leu Ser Tyr Asp Cys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr 
                 85                  90                  95
Ile Ile Asp Lys Ser Lys Ser Val Lys Ser Asn Leu Met Gln Leu Phe 
             100                105                110
Glu Glu Ser Gly Asn Thr Asp Ile Glu Gly Ile Asp Thr Thr Asn Ala 
         115                120                125
Cys Tyr Gly Gly Thr Ala Ala Val Phe Asn Ala Val Asn Trp Ile Glu 
     130                135                140
Ser Ser Ser Trp Asp Gly Arg Tyr Ala Leu Val Val Ala Gly Asp Ile 
 145                150                155                160
Ala Ile Tyr Ala Ser Gly Asn Ala Arg Pro Thr Gly Gly Val Gly Ala 
                 165                170                175
Val Ala Leu Leu Ile Gly Pro Asn Ala Pro Val Ile Phe Asp Arg Gly 
             180                185                190
Leu Arg Gly Thr His Met Gln His Ala Tyr Asp Phe Tyr Lys Pro Asp 
         195                200                205
Met Leu Ser Glu Tyr Pro Val Val Asp Gly Lys Leu Ser Ile Gln Cys 
     210                215                220
Tyr Leu Ser Ala Leu Asp Arg Cys Tyr Ser Val Tyr Arg Lys Lys Ile 
 225                230                235                240
Arg Ala Gln Trp Gln Lys Glu Gly Lys Asp Lys Asp Phe Thr Leu Asn 
                 245                250                255
Asp Phe Gly Phe Met Ile Phe His Ser Pro Tyr Cys Lys Leu Val Gln 
             260                265                270
Lys Ser Leu Ala Arg Met Phe Leu Asn Asp Phe Leu Asn Asp Gln Asn 
         275                280                285
Arg Asp Lys Asn Ser Ile Tyr Ser Gly Leu Glu Ala Phe Gly Asp Val 
     290                295                300
Lys Leu Glu Asp Thr Tyr Phe Asp Arg Asp Val Glu Lys Ala Phe Met 
 305                310                315                320
Lys Ala Ser Ala Glu Leu Phe Asn Gln Lys Thr Lys Ala Ser Leu Leu 
                 325                330                335
Val Ser Asn Gln Asn Gly Asn Met Tyr Thr Ser Ser Val Tyr Gly Ser 
             340                345                350
Leu Ala Ser Val Leu Ala Gln Tyr Ser Pro Gln Gln Leu Ala Gly Lys 
         355                360                365
Arg Ile Gly Val Phe Ser Tyr Gly Ser Gly Leu Ala Ala Thr Leu Tyr 
     370                375                380
Ser Leu Lys Val Thr Gln Asp Ala Thr Pro Gly Ser Ala Leu Asp Lys 
 385                390                395                400
Ile Thr Ala Ser Leu Cys Asp Leu Lys Ser Arg Leu Asp Ser Arg Thr 
                 405                410                415
Cys Val Ala Pro Asp Val Phe Ala Glu Asn Met Lys Leu Arg Glu Asp 
             420                425                430
Thr His His Leu Ala Asn Tyr Ile Pro Gln Cys Ser Ile Asp Ser Leu 
         435                440                445
Phe Glu Gly Thr Trp Tyr Leu Val Arg Val Asp Glu Lys His Arg Arg 
     450                455                460
Thr Tyr Ala Arg Arg Pro Ser Thr Asn Asp His Ser Leu Asp Glu Gly 
 465                470                475                480
Val Gly Leu Val His Ser Asn Thr Ala Thr Glu His Ile Pro Ser Pro 
                 485                490                495
Ala Lys Lys Val Pro Arg Leu Pro Ala Thr Ser Gly Glu Pro Glu Ser 
             500                505                510
Ala Val Ile Ser Asn Gly Glu His 
         515                520



<210> 7056
<211> 2077
<212> DNA
<213> Homo sapiens
<308> BC000297
<400> 7056

ggcacgagg  actcccttt  ctctgctgc  gctcggtca  gcttgtgcc  gaaggagga  60
acagtgaca  acctggaga  tgcagttct  tatccttca  acagctctt  caccatgcc  120
ggatcactt  ctttgaatg  agaagcttg  tggccaaaa  atgtgggaa  tgttgccct  180
gagatctat  ttccttctc  atatgttga  caagcagag  tggaaaaat  tgatggtgt  240
gatgctgga  agtatacca  tggcttggg  caggccaag  tgggcttct  cacagatag  300
gaagatatt  actctcttt  catgactgt  gttcagaat  ttatggaga  aaataacct  360
tcctatgat  gcattgggc  gctggaagt  ggaacagag  caatcatcg  caaatcaaa  420
tctgtgaag  ctaatttga  gcagctgtt  gaagagtct  ggaatacag  tatagaagg  480
atcgacaca  ctaatgcat  ctatggagg  acagctgct  tcttcaatg  tgttaactg  540
attgagtcc  gctcttggg  tggacggta  gccctggta  ttgcaggag  tattgctgt  600
tatgccaca  gaaatgcta  acctacagg  ggagttgga  cagtagctc  gctaattgg  660
ccaaatgct  ctttaattt  tgaacgagg  cttcgtggg  cacatatgc  acatgccta  720
gatttttac  agcctgata  gctatctga  tatcctata  tagatggaa  actctccat  780
cagtgctac  tcagtgcat  agaccgctg  tactctgtc  actgcaaaa  gatccatgc  840
cagtggcag  aagagggaa  tgataaaga  tttaccttg  atgattttg  cttcatgat  900
tttcactca  catattgta  actggttca  aaatctcta  ctcggatgt  gctgaatga  960
ttccttaat  accagaata  agataaaaa  agtatctat  gtggcctgg  agcctttgg  1020
gatgttaaa  tagaagaca  ctactttga  agagatgtg  agaaggcat  tatgaaggc  1080
agctctgaa  tcttcagtc  gaaaacaaa  gcatcttta  ttgtatcaa  tcaaaatgg  1140
aatatgtac  catcttcag  atatggttc  cttgcatct  ttctagcac  gtactcacc  1200
cagcaatta  cagggaaga  aattggagt  ttttcttat  gttctggtt  ggctgccac  1260
ctgtactct  ttaaagtca  acaagatgc  acaccgggg  ctgctcttg  taaaataac  1320
gcaagttta  gtgatctta  atcaaggct  gattcaaga  ctggtgtgg  accagatgt  1380
ttcgctgaa  acatgaagc  cagagagga  acccatcat  tggtcaact  tattcccca  1440
ggttcaata  attcactct  tgaaggaac  tggtactta  ttagggtgg  tgaaaagca  1500
agaagaact  acgctcggc  tcccactcc  aatgatgac  ctttggatg  aggagtagg  1560
cttgtgcat  caaacatag  aactgagca  attccaagc  ctgccaaga  agtaccaag  1620
ctccctgcc  cagcagcag  acctgaagc  gctgtcatt  gtaatgggg  acattaaga  1680
actctgtga  gtgcaagac  tcagggtgg  gtgggcatg  ggtgggggt  tgggaacag  1740
tggaggaat  ggatatctg  ggataattt  aaaggatta  atgttatgt  aatttttat  1800
tgactgaca  ggagcctgg  tgactatcg  gtacttggg  aagtctctt  gctctattt  1860
ctgacatgc  tcctgttgt  gtctggcca  tgccaaatg  actcgaatg  tgttaaggg  1920
tctgtaaaa  ttcatacct  tttggccat  tgtatgcat  atgtttggt  tttaaacat  1980
gtataatga  ttgtgtact  ctgtcagaa  aaagcagag  tactaatct  caattaaaa  2040
attttttaa  atgtaaaaa  aaaaaaaaa  aaaaaaa  2077



<210> 7057
<211> 520
<212> PRT
<213> Homo sapiens
<308> Q01581
<400> 7057

Met Pro Gly Ser Leu Pro Leu Asn Ala Glu Ala Cys Trp Pro Lys Asp 
  1               5                  10                  15
Val Gly Ile Val Ala Leu Glu Ile Tyr Phe Pro Ser Gln Tyr Val Asp 
             20                  25                  30
Gln Ala Glu Leu Glu Lys Tyr Asp Gly Val Asp Ala Gly Lys Tyr Thr 
         35                  40                  45
Ile Gly Leu Gly Gln Ala Lys Met Gly Phe Cys Thr Asp Arg Glu Asp 
     50                  55                  60
Ile Asn Ser Leu Cys Met Thr Val Val Gln Asn Leu Met Glu Arg Asn 
 65                  70                  75                  80
Asn Leu Ser Tyr Asp Cys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr 
                 85                  90                  95
Ile Ile Asp Lys Ser Lys Ser Val Lys Thr Asn Leu Met Gln Leu Phe 
             100                105                110
Glu Glu Ser Gly Asn Thr Asp Ile Glu Gly Ile Asp Thr Thr Asn Ala 
         115                120                125
Cys Tyr Gly Gly Thr Ala Ala Val Phe Asn Ala Val Asn Trp Ile Glu 
     130                135                140
Ser Ser Ser Trp Asp Gly Arg Tyr Ala Leu Val Val Ala Gly Asp Ile 
 145                150                155                160
Ala Val Tyr Ala Thr Gly Asn Ala Arg Pro Thr Gly Gly Val Gly Ala 
                 165                170                175
Val Ala Leu Leu Ile Gly Pro Asn Ala Pro Leu Ile Phe Glu Arg Gly 
             180                185                190
Leu Arg Gly Thr His Met Gln His Ala Tyr Asp Phe Tyr Lys Pro Asp 
         195                200                205
Met Leu Ser Glu Tyr Pro Ile Val Asp Gly Lys Leu Ser Ile Gln Cys 
     210                215                220
Tyr Leu Ser Ala Leu Asp Arg Cys Tyr Ser Val Tyr Cys Lys Lys Ile 
 225                230                235                240
His Ala Gln Trp Gln Lys Glu Gly Asn Asp Lys Asp Phe Thr Leu Asn 
                 245                250                255
Asp Phe Gly Phe Met Ile Phe His Ser Pro Tyr Cys Lys Leu Val Gln 
             260                265                270
Lys Ser Leu Ala Arg Met Leu Leu Asn Asp Phe Leu Asn Asp Gln Asn 
         275                280                285
Arg Asp Lys Asn Ser Ile Tyr Ser Gly Leu Glu Ala Phe Gly Asp Val 
     290                295                300
Lys Leu Glu Asp Thr Tyr Phe Asp Arg Asp Val Glu Lys Ala Phe Met 
 305                310                315                320
Lys Ala Ser Ser Glu Leu Phe Ser Gln Lys Thr Lys Ala Ser Leu Leu 
                 325                330                335
Val Ser Asn Gln Asn Gly Asn Met Tyr Thr Ser Ser Val Tyr Gly Ser 
             340                345                350
Leu Ala Ser Val Leu Ala Gln Tyr Ser Pro Gln Gln Leu Ala Gly Lys 
         355                360                365
Arg Ile Gly Val Phe Ser Tyr Gly Ser Gly Leu Ala Ala Thr Leu Tyr 
     370                375                380
Ser Leu Lys Val Thr Gln Asp Ala Thr Pro Gly Ser Ala Leu Asp Lys 
 385                390                395                400
Ile Thr Ala Ser Leu Cys Asp Leu Lys Ser Arg Leu Asp Ser Arg Thr 
                 405                410                415
Gly Val Ala Pro Asp Val Phe Ala Glu Asn Met Lys Leu Arg Glu Asp 
             420                425                430
Thr His His Leu Val Asn Tyr Ile Pro Gln Gly Ser Ile Asp Ser Leu 
         435                440                445
Phe Glu Gly Thr Trp Tyr Leu Val Arg Val Asp Glu Lys His Arg Arg 
     450                455                460
Thr Tyr Ala Arg Arg Pro Thr Pro Asn Asp Asp Thr Leu Asp Glu Gly 
 465                470                475                480
Val Gly Leu Val His Ser Asn Ile Ala Thr Glu His Ile Pro Ser Pro 
                 485                490                495
Ala Lys Lys Val Pro Arg Leu Pro Ala Thr Ala Ala Glu Pro Glu Ala 
             500                505                510
Ala Val Ile Ser Asn Gly Glu His 
         515                520



<210> 7058
<211> 616
<212> DNA
<213> Rattus norvegicus
<308> AI177161
<400> 7058

aagtcatga  attccttta  tagtgctag  tccttttaa  ttttatcag  gctaaacaa  60
ttaatataa  aatgtcatt  cttgttcat  cagtatata  aaaagtata  tggtttggt  120
agttttcaa  agtttgctt  tagccagat  tcatataag  ctatgactg  aacaaatga  180
aacagtata  ataagttct  tagtattta  acttacaca  aaactagcc  aaatggtgc  240
caagaaatt  acttgagag  taaaatgaa  ctgattcaa  attgagact  taatgcttt  300
taaagtttc  tattatttc  acactagct  tggctataa  tctgcatag  tacttataa  360
gtgtttctg  atttcacat  acagtagga  gttttagcc  tacaaaaca  acactagct  420
agaaaaggc  ccatcctcc  gaacctagt  tttctttgt  tctggcttc  tgctcttgg  480
aacaaggaa  acgttgcca  ctctggtct  ctgcagaga  tactcactg  gagagtaag  540
tttcccatc  tcatcacgt  acatgctga  gacttccag  tacaaagtg  tgagttttc  600
tttcagaag  tggagg  616



<210> 7059
<211> 597
<212> PRT
<213> Rattus norvegicus
<308> O54968
<400> 7059

Met Met Asp Leu Glu Leu Pro Pro Pro Gly Leu Gln Ser Gln Gln Asp 
  1               5                  10                  15
Met Asp Leu Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Val 
             20                  25                  30
Ser Arg Glu Val Phe Asp Phe Ser Gln Arg Gln Lys Asp Tyr Glu Leu 
         35                  40                  45
Glu Lys Gln Lys Lys Leu Glu Lys Glu Arg Gln Glu Gln Leu Gln Lys 
     50                  55                  60
Glu Gln Glu Lys Ala Phe Phe Ala Gln Leu Gln Leu Asp Glu Glu Thr 
 65                  70                  75                  80
Gly Glu Phe Leu Pro Ile Gln Pro Ala Gln His Ile Gln Thr Asp Thr 
                 85                  90                  95
Ser Gly Ser Val Ser Tyr Ser Gln Val Ala His Ile Pro Lys Gln Asp 
             100                105                110
Ala Leu Tyr Phe Glu Asp Cys Met Gln Leu Leu Ala Glu Thr Phe Pro 
         115                120                125
Phe Val Asp Asp His Glu Ser Leu Ala Leu Asp Ile Pro Ser His Val 
     130                135                140
Glu Ser Ser Val Phe Thr Thr Pro Asp Gln Ala Gln Ser Leu Asp Ser 
 145                150                155                160
Ser Leu Glu Thr Ala Met Thr Asp Leu Ser Ser Ile Gln Gln Asp Met 
                 165                170                175
Glu Gln Val Trp Gln Glu Leu Phe Ser Ile Pro Glu Leu Gln Cys Leu 
             180                185                190
Asn Thr Glu Asn Lys Gln Gln Ala Glu Thr Thr Thr Val Pro Ser Pro 
         195                200                205
Glu Ala Thr Leu Thr Glu Met Asp Ser Asn Tyr His Phe Tyr Ser Ser 
     210                215                220
Ile Pro Ser Leu Glu Lys Glu Val Asp Ser Cys Ser Pro His Phe Leu 
 225                230                235                240
His Gly Phe Glu Asp Ser Phe Ser Ser Ile Leu Ser Thr Asp Asp Ala 
                 245                250                255
Ser Gln Leu Asn Ser Leu Asp Ser Asn Pro Thr Leu Asn Thr Asp Phe 
             260                265                270
Gly Asp Glu Phe Tyr Ser Ala Phe Leu Ala Glu Pro Ser Gly Gly Gly 
         275                280                285
Ser Met Pro Ser Ser Ala Ala Ile Ser Gln Ser Leu Ser Glu Leu Leu 
     290                295                300
Gly Gly Pro Ile Glu Gly Cys Asp Leu Ser Leu Cys Lys Ala Phe Asn 
 305                310                315                320
Gln Lys His Thr Glu Gly Thr Val Glu Phe Asn Asp Ser Asp Ser Gly 
                 325                330                335
Ile Ser Leu Asn Thr Ser Pro Ser Arg Ala Ser Pro Glu His Ser Val 
             340                345                350
Glu Ser Ser Ile Tyr Gly Asp Pro Pro Pro Gly Phe Ser Asp Ser Glu 
         355                360                365
Met Glu Glu Leu Asp Ser Ala Pro Gly Ser Val Lys Gln Asn Gly Pro 
     370                375                380
Lys Ala Gln Pro Thr His Ser Ser Gly Asp Thr Val Gln Pro Leu Ser 
 385                390                395                400
Pro Ala Gln Gly His Ser Ala Ala Val His Glu Ser Gln Cys Glu Asn 
                 405                410                415
Thr Thr Lys Lys Glu Val Pro Val Ser Pro Gly His Gln Lys Val Pro 
             420                425                430
Phe Thr Lys Asp Lys His Ser Ser Arg Leu Glu Ala His Leu Thr Arg 
         435                440                445
Asp Glu Leu Arg Ala Lys Ala Leu His Ile Pro Phe Pro Val Glu Lys 
     450                455                460
Ile Ile Asn Leu Pro Val Asp Asp Phe Asn Glu Met Met Ser Lys Glu 
 465                470                475                480
Gln Phe Asn Glu Ala Gln Leu Ala Leu Ile Arg Asp Ile Arg Arg Arg 
                 485                490                495
Gly Lys Asn Lys Val Ala Ala Gln Asn Cys Arg Lys Arg Lys Leu Glu 
             500                505                510
Asn Ile Val Glu Leu Glu Gln Asp Leu Gly His Leu Lys Asp Glu Arg 
         515                520                525
Glu Lys Leu Leu Arg Glu Lys Gly Glu Asn Asp Arg Asn Leu His Leu 
     530                535                540
Leu Lys Arg Lys Leu Ser Thr Leu Tyr Leu Glu Val Phe Ser Met Leu 
 545                550                555                560
Arg Asp Glu Asp Gly Lys Pro Tyr Ser Pro Ser Glu Tyr Ser Leu Gln 
                 565                570                575
Gln Thr Arg Asp Gly Asn Val Phe Leu Val Pro Lys Ser Lys Lys Pro 
             580                585                590
Asp Thr Lys Lys Asn 
         595



<210> 7060
<211> 2304
<212> DNA
<213> Homo sapiens
<308> S74017
<400> 7060

ttggagctg  cgccgccgg  actcccgtc  cagcaggac  tggatttga  tgacatact  60
tggaggcaa  atatagatc  tggagtaag  cgagaagta  ttgacttca  tcagcgacg  120
aaagagtat  agctggaaa  acagaaaaa  cttgaaaag  aaagacaag  acaactcca  180
aaggagcaa  agaaagcct  tttcactca  ttacaacta  atgaagaga  aggtgaatt  240
ctcccaatt  agccagccc  gcacaccca  tcagaaacc  gtggatctg  caactactc  300
caggttgcc  acattccca  atcagatgc  ttgtacttt  atgactgca  gcagctttt  360
gcgcagaca  tcccgtttg  agatgacaa  gaggtttct  cggctacgt  tcagtcact  420
gttcctgat  ttcccggtc  catcgagag  ccagtcttc  ttgctacta  tcaggctca  480
tcacctgaa  cttctgttg  tcaggtagc  cctgttgat  tagacggta  gcaacagga  540
attgagcaa  tttgggagg  gctattatc  attcctgag  tacagtgtc  taatattga  600
aatgacaag  tggttgaga  taccatggt  ccaagtcca  aagccaaac  gacagaagt  660
gacaattat  atttttact  atctatacc  tcaatggaa  aagaagtag  taactgtag  720
ccacatttt  ttaatgctt  tgaggattc  ttcagcagc  tcctctcca  agaagaccc  780
aaccagttg  cagtgaact  attaaattc  gatgccaca  tcaacacag  ttttggtga  840
gaattttat  ctgctttca  agctgagcc  agtatcagc  acagcatgc  ctcacctgc  900
actttaagc  attcactct  tgaacttct  aatgggccc  ttgatgttt  tgatctatc  960
ctttgcaaa  ctttcaacc  aaaccaccc  gaaagcaca  cagaattca  tgattctga  1020
tccggcatt  cactaaaca  aagtcccag  gtggcatca  cagaacact  agtggaatc  1080
tccagctat  gagacacac  acttggcct  agtgattct  aagtggaag  gctagatag  1140
gcccctgga  gtgtcaaac  gaatggtcc  aaaacacca  tacattctt  tggggatat  1200
gtacaaccc  tgtcaccat  tcaggggca  agcactcac  tgcatgatg  ccaatgtga  1260
aacacacca  agaaagaat  gcctgtaag  cctggtcat  ggaaaaccc  attcacaaa  1320
gacaaacat  caagccgct  ggaggctca  ctcacaaga  atgaactta  ggcaaaagc  1380
ctccatatc  cattccctg  agaaaaaat  attaacctc  ctgttgttg  cttcaacga  1440
atgatgtcc  aagagcagt  caatgaagc  caacttgca  taattcggg  tatacgtag  1500
aggggtaag  ataaagtgg  tgctcagaa  tgcagaaaa  gaaaactgg  aaatatagt  1560
gaactagag  aagatttag  tcatttgaa  gatgaaaaa  aaaaattgc  caaagaaaa  1620
ggagaaaat  acaaaagcc  tcacctact  aaaaaacaa  tcagcacct  atatctcga  1680
gttttcagc  tgctacgtg  tgaagatgg  aaaccttat  ctcctagtg  atactccct  1740
cagcaaaca  gagatggca  tgttttcct  gttcccaaa  gtaagaagc  agatgttaa  1800
aaaaactag  tttaggagg  tttgacctt  tctgagcta  tttttttgt  ctattatac  1860
aaaagctcc  actgtgatg  gaaatgctc  tactttata  gtaattcta  gcaaaatca  1920
agccaaaac  agtatagaa  ataatacga  actttaaaa  gcattggag  gtcagtatg  1980
tgaatcagt  gtttcactt  aactgtaaa  aatttctta  gacaccatt  gggctagtt  2040
ctgtgtaag  gtaaatact  caaaaactt  tttatactg  tcttatgtc  tttgttata  2100
tcatagatt  atatgatga  atgacatct  gctaaaaag  aattattgc  aaactaacc  2160
cgatgtact  ttttataaa  actgtatgg  caaaaaatg  catttttta  aattaaatt  2220
tttagctct  gcaaaaaaa  aaaattttt  aagagctgg  actaataaa  gattattat  2280
actgttaaa  aaaaaaaaa  aaaa  2304



<210> 7061
<211> 605
<212> PRT
<213> Homo sapiens
<308> Q16236
<400> 7061

Met Met Asp Leu Glu Leu Pro Pro Pro Gly Leu Pro Ser Gln Gln Asp 
  1               5                  10                  15
Met Asp Leu Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Val 
             20                  25                  30
Ser Arg Glu Val Phe Asp Phe Ser Gln Arg Arg Lys Glu Tyr Glu Leu 
         35                  40                  45
Glu Lys Gln Lys Lys Leu Glu Lys Glu Arg Gln Glu Gln Leu Gln Lys 
     50                  55                  60
Glu Gln Glu Lys Ala Phe Phe Thr Gln Leu Gln Leu Asp Glu Glu Thr 
 65                  70                  75                  80
Gly Glu Phe Leu Pro Ile Gln Pro Ala Gln His Thr Gln Ser Glu Thr 
                 85                  90                  95
Ser Gly Ser Ala Asn Tyr Ser Gln Val Ala His Ile Pro Lys Ser Asp 
             100                105                110
Ala Leu Tyr Phe Asp Asp Cys Met Gln Leu Leu Ala Gln Thr Phe Pro 
         115                120                125
Phe Val Asp Asp Asn Glu Val Ser Ser Ala Thr Phe Gln Ser Leu Val 
     130                135                140
Pro Asp Ile Pro Gly His Ile Glu Ser Pro Val Phe Ile Ala Thr Asn 
 145                150                155                160
Gln Ala Gln Ser Pro Glu Thr Ser Val Ala Gln Val Ala Pro Val Asp 
                 165                170                175
Leu Asp Gly Met Gln Gln Asp Ile Glu Gln Val Trp Glu Glu Leu Leu 
             180                185                190
Ser Ile Pro Glu Leu Gln Cys Leu Asn Ile Glu Asn Asp Lys Leu Val 
         195                200                205
Glu Thr Thr Met Val Pro Ser Pro Glu Ala Lys Leu Thr Glu Val Asp 
     210                215                220
Asn Tyr His Phe Tyr Ser Ser Ile Pro Ser Met Glu Lys Glu Val Gly 
 225                230                235                240
Asn Cys Ser Pro His Phe Leu Asn Ala Phe Glu Asp Ser Phe Ser Ser 
                 245                250                255
Ile Leu Ser Thr Glu Asp Pro Asn Gln Leu Thr Val Asn Ser Leu Asn 
             260                265                270
Ser Asp Ala Thr Val Asn Thr Asp Phe Gly Asp Glu Phe Tyr Ser Ala 
         275                280                285
Phe Ile Ala Glu Pro Ser Ile Ser Asn Ser Met Pro Ser Pro Ala Thr 
     290                295                300
Leu Ser His Ser Leu Ser Glu Leu Leu Asn Gly Pro Ile Asp Val Ser 
 305                310                315                320
Asp Leu Ser Leu Cys Lys Ala Phe Asn Gln Asn His Pro Glu Ser Thr 
                 325                330                335
Ala Glu Phe Asn Asp Ser Asp Ser Gly Ile Ser Leu Asn Thr Ser Pro 
             340                345                350
Ser Val Ala Ser Pro Glu His Ser Val Glu Ser Ser Ser Tyr Gly Asp 
         355                360                365
Thr Leu Leu Gly Leu Ser Asp Ser Glu Val Glu Glu Leu Asp Ser Ala 
     370                375                380
Pro Gly Ser Val Lys Gln Asn Gly Pro Lys Thr Pro Val His Ser Ser 
 385                390                395                400
Gly Asp Met Val Gln Pro Leu Ser Pro Ser Gln Gly Gln Ser Thr His 
                 405                410                415
Val His Asp Ala Gln Cys Glu Asn Thr Pro Glu Lys Glu Leu Pro Val 
             420                425                430
Ser Pro Gly His Arg Lys Thr Pro Phe Thr Lys Asp Lys His Ser Ser 
         435                440                445
Arg Leu Glu Ala His Leu Thr Arg Asp Glu Leu Arg Ala Lys Ala Leu 
     450                455                460
His Ile Pro Phe Pro Val Glu Lys Ile Ile Asn Leu Pro Val Val Asp 
 465                470                475                480
Phe Asn Glu Met Met Ser Lys Glu Gln Phe Asn Glu Ala Gln Leu Ala 
                 485                490                495
Leu Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Val Ala Ala Gln 
             500                505                510
Asn Cys Arg Lys Arg Lys Leu Glu Asn Ile Val Glu Leu Glu Gln Asp 
         515                520                525
Leu Asp His Leu Lys Asp Glu Lys Glu Lys Leu Leu Lys Glu Lys Gly 
     530                535                540
Glu Asn Asp Lys Ser Leu His Leu Leu Lys Lys Gln Leu Ser Thr Leu 
 545                550                555                560
Tyr Leu Glu Val Phe Ser Met Leu Arg Asp Glu Asp Gly Lys Pro Tyr 
                 565                570                575
Ser Pro Ser Glu Tyr Ser Leu Gln Gln Thr Arg Asp Gly Asn Val Phe 
             580                585                590
Leu Val Pro Lys Ser Lys Lys Pro Asp Val Lys Lys Asn 
         595                600                605



<210> 7062
<211> 616
<212> DNA
<213> Rattus norvegicus
<308> AI177161
<400> 7062

aagtcatga  attccttta  tagtgctag  tccttttaa  ttttatcag  gctaaacaa  60
ttaatataa  aatgtcatt  cttgttcat  cagtatata  aaaagtata  tggtttggt  120
agttttcaa  agtttgctt  tagccagat  tcatataag  ctatgactg  aacaaatga  180
aacagtata  ataagttct  tagtattta  acttacaca  aaactagcc  aaatggtgc  240
caagaaatt  acttgagag  taaaatgaa  ctgattcaa  attgagact  taatgcttt  300
taaagtttc  tattatttc  acactagct  tggctataa  tctgcatag  tacttataa  360
gtgtttctg  atttcacat  acagtagga  gttttagcc  tacaaaaca  acactagct  420
agaaaaggc  ccatcctcc  gaacctagt  tttctttgt  tctggcttc  tgctcttgg  480
aacaaggaa  acgttgcca  ctctggtct  ctgcagaga  tactcactg  gagagtaag  540
tttcccatc  tcatcacgt  acatgctga  gacttccag  tacaaagtg  tgagttttc  600
tttcagaag  tggagg  616



<210> 7063
<211> 597
<212> PRT
<213> Rattus norvegicus
<308> O54968
<400> 7063

Met Met Asp Leu Glu Leu Pro Pro Pro Gly Leu Gln Ser Gln Gln Asp 
  1               5                  10                  15
Met Asp Leu Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Val 
             20                  25                  30
Ser Arg Glu Val Phe Asp Phe Ser Gln Arg Gln Lys Asp Tyr Glu Leu 
         35                  40                  45
Glu Lys Gln Lys Lys Leu Glu Lys Glu Arg Gln Glu Gln Leu Gln Lys 
     50                  55                  60
Glu Gln Glu Lys Ala Phe Phe Ala Gln Leu Gln Leu Asp Glu Glu Thr 
 65                  70                  75                  80
Gly Glu Phe Leu Pro Ile Gln Pro Ala Gln His Ile Gln Thr Asp Thr 
                 85                  90                  95
Ser Gly Ser Val Ser Tyr Ser Gln Val Ala His Ile Pro Lys Gln Asp 
             100                105                110
Ala Leu Tyr Phe Glu Asp Cys Met Gln Leu Leu Ala Glu Thr Phe Pro 
         115                120                125
Phe Val Asp Asp His Glu Ser Leu Ala Leu Asp Ile Pro Ser His Val 
     130                135                140
Glu Ser Ser Val Phe Thr Thr Pro Asp Gln Ala Gln Ser Leu Asp Ser 
 145                150                155                160
Ser Leu Glu Thr Ala Met Thr Asp Leu Ser Ser Ile Gln Gln Asp Met 
                 165                170                175
Glu Gln Val Trp Gln Glu Leu Phe Ser Ile Pro Glu Leu Gln Cys Leu 
             180                185                190
Asn Thr Glu Asn Lys Gln Gln Ala Glu Thr Thr Thr Val Pro Ser Pro 
         195                200                205
Glu Ala Thr Leu Thr Glu Met Asp Ser Asn Tyr His Phe Tyr Ser Ser 
     210                215                220
Ile Pro Ser Leu Glu Lys Glu Val Asp Ser Cys Ser Pro His Phe Leu 
 225                230                235                240
His Gly Phe Glu Asp Ser Phe Ser Ser Ile Leu Ser Thr Asp Asp Ala 
                 245                250                255
Ser Gln Leu Asn Ser Leu Asp Ser Asn Pro Thr Leu Asn Thr Asp Phe 
             260                265                270
Gly Asp Glu Phe Tyr Ser Ala Phe Leu Ala Glu Pro Ser Gly Gly Gly 
         275                280                285
Ser Met Pro Ser Ser Ala Ala Ile Ser Gln Ser Leu Ser Glu Leu Leu 
     290                295                300
Gly Gly Pro Ile Glu Gly Cys Asp Leu Ser Leu Cys Lys Ala Phe Asn 
 305                310                315                320
Gln Lys His Thr Glu Gly Thr Val Glu Phe Asn Asp Ser Asp Ser Gly 
                 325                330                335
Ile Ser Leu Asn Thr Ser Pro Ser Arg Ala Ser Pro Glu His Ser Val 
             340                345                350
Glu Ser Ser Ile Tyr Gly Asp Pro Pro Pro Gly Phe Ser Asp Ser Glu 
         355                360                365
Met Glu Glu Leu Asp Ser Ala Pro Gly Ser Val Lys Gln Asn Gly Pro 
     370                375                380
Lys Ala Gln Pro Thr His Ser Ser Gly Asp Thr Val Gln Pro Leu Ser 
 385                390                395                400
Pro Ala Gln Gly His Ser Ala Ala Val His Glu Ser Gln Cys Glu Asn 
                 405                410                415
Thr Thr Lys Lys Glu Val Pro Val Ser Pro Gly His Gln Lys Val Pro 
             420                425                430
Phe Thr Lys Asp Lys His Ser Ser Arg Leu Glu Ala His Leu Thr Arg 
         435                440                445
Asp Glu Leu Arg Ala Lys Ala Leu His Ile Pro Phe Pro Val Glu Lys 
     450                455                460
Ile Ile Asn Leu Pro Val Asp Asp Phe Asn Glu Met Met Ser Lys Glu 
 465                470                475                480
Gln Phe Asn Glu Ala Gln Leu Ala Leu Ile Arg Asp Ile Arg Arg Arg 
                 485                490                495
Gly Lys Asn Lys Val Ala Ala Gln Asn Cys Arg Lys Arg Lys Leu Glu 
             500                505                510
Asn Ile Val Glu Leu Glu Gln Asp Leu Gly His Leu Lys Asp Glu Arg 
         515                520                525
Glu Lys Leu Leu Arg Glu Lys Gly Glu Asn Asp Arg Asn Leu His Leu 
     530                535                540
Leu Lys Arg Lys Leu Ser Thr Leu Tyr Leu Glu Val Phe Ser Met Leu 
 545                550                555                560
Arg Asp Glu Asp Gly Lys Pro Tyr Ser Pro Ser Glu Tyr Ser Leu Gln 
                 565                570                575
Gln Thr Arg Asp Gly Asn Val Phe Leu Val Pro Lys Ser Lys Lys Pro 
             580                585                590
Asp Thr Lys Lys Asn 
         595



<210> 7064
<211> 2304
<212> DNA
<213> Homo sapiens
<308> S74017
<400> 7064

ttggagctg  cgccgccgg  actcccgtc  cagcaggac  tggatttga  tgacatact  60
tggaggcaa  atatagatc  tggagtaag  cgagaagta  ttgacttca  tcagcgacg  120
aaagagtat  agctggaaa  acagaaaaa  cttgaaaag  aaagacaag  acaactcca  180
aaggagcaa  agaaagcct  tttcactca  ttacaacta  atgaagaga  aggtgaatt  240
ctcccaatt  agccagccc  gcacaccca  tcagaaacc  gtggatctg  caactactc  300
caggttgcc  acattccca  atcagatgc  ttgtacttt  atgactgca  gcagctttt  360
gcgcagaca  tcccgtttg  agatgacaa  gaggtttct  cggctacgt  tcagtcact  420
gttcctgat  ttcccggtc  catcgagag  ccagtcttc  ttgctacta  tcaggctca  480
tcacctgaa  cttctgttg  tcaggtagc  cctgttgat  tagacggta  gcaacagga  540
attgagcaa  tttgggagg  gctattatc  attcctgag  tacagtgtc  taatattga  600
aatgacaag  tggttgaga  taccatggt  ccaagtcca  aagccaaac  gacagaagt  660
gacaattat  atttttact  atctatacc  tcaatggaa  aagaagtag  taactgtag  720
ccacatttt  ttaatgctt  tgaggattc  ttcagcagc  tcctctcca  agaagaccc  780
aaccagttg  cagtgaact  attaaattc  gatgccaca  tcaacacag  ttttggtga  840
gaattttat  ctgctttca  agctgagcc  agtatcagc  acagcatgc  ctcacctgc  900
actttaagc  attcactct  tgaacttct  aatgggccc  ttgatgttt  tgatctatc  960
ctttgcaaa  ctttcaacc  aaaccaccc  gaaagcaca  cagaattca  tgattctga  1020
tccggcatt  cactaaaca  aagtcccag  gtggcatca  cagaacact  agtggaatc  1080
tccagctat  gagacacac  acttggcct  agtgattct  aagtggaag  gctagatag  1140
gcccctgga  gtgtcaaac  gaatggtcc  aaaacacca  tacattctt  tggggatat  1200
gtacaaccc  tgtcaccat  tcaggggca  agcactcac  tgcatgatg  ccaatgtga  1260
aacacacca  agaaagaat  gcctgtaag  cctggtcat  ggaaaaccc  attcacaaa  1320
gacaaacat  caagccgct  ggaggctca  ctcacaaga  atgaactta  ggcaaaagc  1380
ctccatatc  cattccctg  agaaaaaat  attaacctc  ctgttgttg  cttcaacga  1440
atgatgtcc  aagagcagt  caatgaagc  caacttgca  taattcggg  tatacgtag  1500
aggggtaag  ataaagtgg  tgctcagaa  tgcagaaaa  gaaaactgg  aaatatagt  1560
gaactagag  aagatttag  tcatttgaa  gatgaaaaa  aaaaattgc  caaagaaaa  1620
ggagaaaat  acaaaagcc  tcacctact  aaaaaacaa  tcagcacct  atatctcga  1680
gttttcagc  tgctacgtg  tgaagatgg  aaaccttat  ctcctagtg  atactccct  1740
cagcaaaca  gagatggca  tgttttcct  gttcccaaa  gtaagaagc  agatgttaa  1800
aaaaactag  tttaggagg  tttgacctt  tctgagcta  tttttttgt  ctattatac  1860
aaaagctcc  actgtgatg  gaaatgctc  tactttata  gtaattcta  gcaaaatca  1920
agccaaaac  agtatagaa  ataatacga  actttaaaa  gcattggag  gtcagtatg  1980
tgaatcagt  gtttcactt  aactgtaaa  aatttctta  gacaccatt  gggctagtt  2040
ctgtgtaag  gtaaatact  caaaaactt  tttatactg  tcttatgtc  tttgttata  2100
tcatagatt  atatgatga  atgacatct  gctaaaaag  aattattgc  aaactaacc  2160
cgatgtact  ttttataaa  actgtatgg  caaaaaatg  catttttta  aattaaatt  2220
tttagctct  gcaaaaaaa  aaaattttt  aagagctgg  actaataaa  gattattat  2280
actgttaaa  aaaaaaaaa  aaaa  2304



<210> 7065
<211> 605
<212> PRT
<213> Homo sapiens
<308> Q16236
<400> 7065

Met Met Asp Leu Glu Leu Pro Pro Pro Gly Leu Pro Ser Gln Gln Asp 
  1               5                  10                  15
Met Asp Leu Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Val 
             20                  25                  30
Ser Arg Glu Val Phe Asp Phe Ser Gln Arg Arg Lys Glu Tyr Glu Leu 
         35                  40                  45
Glu Lys Gln Lys Lys Leu Glu Lys Glu Arg Gln Glu Gln Leu Gln Lys 
     50                  55                  60
Glu Gln Glu Lys Ala Phe Phe Thr Gln Leu Gln Leu Asp Glu Glu Thr 
 65                  70                  75                  80
Gly Glu Phe Leu Pro Ile Gln Pro Ala Gln His Thr Gln Ser Glu Thr 
                 85                  90                  95
Ser Gly Ser Ala Asn Tyr Ser Gln Val Ala His Ile Pro Lys Ser Asp 
             100                105                110
Ala Leu Tyr Phe Asp Asp Cys Met Gln Leu Leu Ala Gln Thr Phe Pro 
         115                120                125
Phe Val Asp Asp Asn Glu Val Ser Ser Ala Thr Phe Gln Ser Leu Val 
     130                135                140
Pro Asp Ile Pro Gly His Ile Glu Ser Pro Val Phe Ile Ala Thr Asn 
 145                150                155                160
Gln Ala Gln Ser Pro Glu Thr Ser Val Ala Gln Val Ala Pro Val Asp 
                 165                170                175
Leu Asp Gly Met Gln Gln Asp Ile Glu Gln Val Trp Glu Glu Leu Leu 
             180                185                190
Ser Ile Pro Glu Leu Gln Cys Leu Asn Ile Glu Asn Asp Lys Leu Val 
         195                200                205
Glu Thr Thr Met Val Pro Ser Pro Glu Ala Lys Leu Thr Glu Val Asp 
     210                215                220
Asn Tyr His Phe Tyr Ser Ser Ile Pro Ser Met Glu Lys Glu Val Gly 
 225                230                235                240
Asn Cys Ser Pro His Phe Leu Asn Ala Phe Glu Asp Ser Phe Ser Ser 
                 245                250                255
Ile Leu Ser Thr Glu Asp Pro Asn Gln Leu Thr Val Asn Ser Leu Asn 
             260                265                270
Ser Asp Ala Thr Val Asn Thr Asp Phe Gly Asp Glu Phe Tyr Ser Ala 
         275                280                285
Phe Ile Ala Glu Pro Ser Ile Ser Asn Ser Met Pro Ser Pro Ala Thr 
     290                295                300
Leu Ser His Ser Leu Ser Glu Leu Leu Asn Gly Pro Ile Asp Val Ser 
 305                310                315                320
Asp Leu Ser Leu Cys Lys Ala Phe Asn Gln Asn His Pro Glu Ser Thr 
                 325                330                335
Ala Glu Phe Asn Asp Ser Asp Ser Gly Ile Ser Leu Asn Thr Ser Pro 
             340                345                350
Ser Val Ala Ser Pro Glu His Ser Val Glu Ser Ser Ser Tyr Gly Asp 
         355                360                365
Thr Leu Leu Gly Leu Ser Asp Ser Glu Val Glu Glu Leu Asp Ser Ala 
     370                375                380
Pro Gly Ser Val Lys Gln Asn Gly Pro Lys Thr Pro Val His Ser Ser 
 385                390                395                400
Gly Asp Met Val Gln Pro Leu Ser Pro Ser Gln Gly Gln Ser Thr His 
                 405                410                415
Val His Asp Ala Gln Cys Glu Asn Thr Pro Glu Lys Glu Leu Pro Val 
             420                425                430
Ser Pro Gly His Arg Lys Thr Pro Phe Thr Lys Asp Lys His Ser Ser 
         435                440                445
Arg Leu Glu Ala His Leu Thr Arg Asp Glu Leu Arg Ala Lys Ala Leu 
     450                455                460
His Ile Pro Phe Pro Val Glu Lys Ile Ile Asn Leu Pro Val Val Asp 
 465                470                475                480
Phe Asn Glu Met Met Ser Lys Glu Gln Phe Asn Glu Ala Gln Leu Ala 
                 485                490                495
Leu Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Val Ala Ala Gln 
             500                505                510
Asn Cys Arg Lys Arg Lys Leu Glu Asn Ile Val Glu Leu Glu Gln Asp 
         515                520                525
Leu Asp His Leu Lys Asp Glu Lys Glu Lys Leu Leu Lys Glu Lys Gly 
     530                535                540
Glu Asn Asp Lys Ser Leu His Leu Leu Lys Lys Gln Leu Ser Thr Leu 
 545                550                555                560
Tyr Leu Glu Val Phe Ser Met Leu Arg Asp Glu Asp Gly Lys Pro Tyr 
                 565                570                575
Ser Pro Ser Glu Tyr Ser Leu Gln Gln Thr Arg Asp Gly Asn Val Phe 
             580                585                590
Leu Val Pro Lys Ser Lys Lys Pro Asp Val Lys Lys Asn 
         595                600                605



<210> 7066
<211> 684
<212> DNA
<213> Rattus norvegicus
<308> AI177404
<400> 7066

ttcaaaaca  tttattgca  catatttgg  accttatgt  tgacaacaa  aaagaaatt  60
catttgtaa  tgcaggaaa  agaagctgg  ctgttattg  aaagaaaaa  cttgggccc  120
ttaaaaatt  caaagtctt  ggcttgcct  aaacaactg  gcaagaaat  tattcttag  180
aatgaaggg  ttcaagtat  acaaacctg  gacactgtg  aaaagttcc  gaggtatct  240
aactgcagc  ctttttctg  atatcgtga  caaggcctg  tgaggtttt  agctattag  300
ctcttgatc  gaatggtag  caggagttc  gctctttaa  ttcaagcca  ggtagagtt  360
ccttttttc  ctctcaggt  aaaaagtca  gcttgctaa  tagttggtg  cacatcaca  420
tgcatttgg  tcttgcatt  cagttttaa  aagtttggc  aaaacaatg  taaagcttt  480
cattgttat  ttagttctt  aagttttag  taaattgag  ttgttccaa  tggttcctt  540
ggttaaaaa  tgtggtaca  gaacaccaa  ctgatcatg  acagtgaat  ttggaaaca  600
aacacacgt  ctgaacacc  tctaggttt  atttaatct  cttggtagc  atgtgtcca  660
gttatctac  acgtcaagc  tctg  684



<210> 7067
<211> 594
<212> PRT
<213> Rattus norvegicus
<308> AAF73953
<400> 7067

Met Leu Glu Arg Leu Lys Ile Tyr Glu Glu Ala Trp Thr Lys Tyr Pro 
  1               5                  10                  15
Arg Gly Leu Val Pro Arg Lys Leu Pro Leu Asn Phe Leu Ser Gly Glu 
             20                  25                  30
Lys Phe Lys Glu Cys Leu Asp Arg Phe Leu Arg Met Asn Phe Ser Lys 
         35                  40                  45
Gly Cys Pro Pro Val Phe Asn Thr Leu Arg Ser Leu Tyr Arg Asp Lys 
     50                  55                  60
Glu Lys Val Ala Ile Val Glu Glu Leu Val Val Gly Tyr Glu Thr Ser 
 65                  70                  75                  80
Leu Lys Ser Cys Arg Leu Phe Asn Pro Asn Asp Asp Gly Lys Glu Glu 
                 85                  90                  95
Pro Pro Thr Thr Leu Leu Trp Val Gln Tyr Tyr Leu Ala Gln His Tyr 
             100                105                110
Asp Lys Ile Gly Gln Pro Ser Ile Ala Leu Glu Tyr Ile Asn Thr Ala 
         115                120                125
Ile Glu Ser Thr Pro Thr Leu Ile Glu Leu Phe Leu Val Lys Ala Lys 
     130                135                140
Ile Tyr Lys His Ala Gly Asn Ile Lys Glu Ala Ala Arg Trp Met Asp 
 145                150                155                160
Glu Ala Gln Ala Leu Asp Thr Ala Asp Arg Phe Ile Asn Ser Lys Cys 
                 165                170                175
Ala Lys Tyr Met Leu Lys Ala Asn Leu Ile Lys Glu Ala Glu Glu Met 
             180                185                190
Cys Ser Lys Phe Thr Arg Glu Gly Thr Ser Ala Val Glu Asn Leu Asn 
         195                200                205
Glu Met Gln Cys Met Trp Phe Gln Thr Glu Cys Ala Gln Ala Tyr Lys 
     210                215                220
Ala Met Asn Lys Phe Gly Glu Ala Leu Lys Lys Cys His Glu Ile Glu 
 225                230                235                240
Arg His Phe Ile Glu Ile Thr Asp Asp Gln Phe Asp Phe His Thr Tyr 
                 245                250                255
Cys Met Arg Lys Ile Thr Leu Arg Ser Tyr Val Asp Leu Leu Lys Leu 
             260                265                270
Glu Asp Val Leu Arg Gln His Pro Phe Tyr Phe Lys Ala Ala Arg Ile 
         275                280                285
Ala Ile Glu Ile Tyr Leu Lys Leu His Asp Asn Pro Leu Thr Asp Glu 
     290                295                300
Asn Lys Glu His Glu Ala Asp Thr Ala Asn Met Ser Asp Lys Glu Leu 
 305                310                315                320
Lys Lys Leu Arg Asn Lys Gln Arg Arg Ala Gln Lys Lys Ala Gln Ile 
                 325                330                335
Glu Glu Glu Lys Lys Asn Ala Glu Lys Glu Lys Pro Gln Arg Asn Pro 
             340                345                350
Lys Lys Lys Lys Asp Asp Asp Asp Glu Glu Ile Gly Gly Pro Lys Glu 
         355                360                365
Glu Leu Ile Pro Glu Lys Leu Ala Lys Val Glu Thr Pro Leu Glu Glu 
     370                375                380
Ala Ile Lys Phe Leu Thr Pro Leu Lys Asn Leu Val Lys Asn Lys Ile 
 385                390                395                400
Glu Thr His Leu Phe Ala Phe Glu Ile Tyr Phe Arg Lys Glu Lys Phe 
                 405                410                415
Leu Leu Met Leu Gln Ser Val Lys Arg Ala Phe Ala Ile Asp Ser Ser 
             420                425                430
His Pro Trp Leu His Glu Cys Met Ile Arg Leu Phe His Ser Val Cys 
         435                440                445
Glu Ser Lys Asp Leu Pro Glu Thr Val Arg Thr Val Leu Lys Gln Glu 
     450                455                460
Met Asn Arg Leu Phe Gly Ala Thr Asn Pro Lys Asn Phe Asn Glu Thr 
 465                470                475                480
Phe Leu Lys Arg Asn Ser Asp Ser Leu Pro His Arg Leu Ser Ala Ala 
                 485                490                495
Lys Met Val Tyr Tyr Leu Asp Ser Ser Ser Gln Lys Arg Ala Ile Glu 
             500                505                510
Leu Ala Thr Thr Leu Asp Gly Ile Pro His Gln Gln Lys Pro Ser Asp 
         515                520                525
Leu His Gly Ser Val Gly Lys Pro Cys Cys Asp Gly Ser Leu Arg Asp 
     530                535                540
Cys Lys Glu Ala Ala Glu Ala Tyr Arg Ala Ser Cys His Lys Leu Phe 
 545                550                555                560
Pro Tyr Ala Leu Ala Phe Met Pro Pro Gly Tyr Glu Glu Asp Met Lys 
                 565                570                575
Ile Thr Val Asn Gly Asp Ser Ser Ala Glu Thr Glu Glu Leu Ala Asn 
             580                585                590
Glu Ile 
         595



<210> 7068
<211> 2859
<212> DNA
<213> Homo sapiens
<308> AK001595
<400> 7068

gattatcag  tgccaaaat  gtatattac  tagatcctt  tagtcagaa  cgagctata  60
agttggcaa  aacacttga  gaatctctc  ctaacagaa  cctccagac  tgtatggag  120
tattggaag  cttgtatga  ggtagccta  gagactgta  agaagctgc  gaaatttat  180
gagcaaatt  tcataagct  ttcccttat  ctttggctt  catgcctcc  ggatatgaa  240
aggatatga  gatcacagt  aatggagat  gttctgcag  agctgaaga  ctggccaat  300
aaatttgaa  atcactaaa  aagcaaatg  aatgacttt  gaccatatc  agtatataa  360
atttttgtc  cgcacctgc  gcattgctc  aacttacac  gaatgagag  agtaaatgt  420
cttgccttc  aatagtgtt  tacgttttt  atcctgctg  aaaagtata  ataaaatat  480
taacattac  ggatagagg  tcagtttct  aaaaaatta  agctgctaa  attgagtgg  540
taaaaaaga  accttatcc  attcctccc  acccaccca  gtttttaaa  taatttata  600
aaaatctgg  ggctgttac  gctaacaaa  caggtgtgt  gcagaaata  tactttaaa  660
ttgtcttgt  agattttac  atatctcag  cagcataaa  gctgtttta  cactggatt  720
tttcactga  cacaaagag  tgttggggc  ttagcatct  actgatttt  ttacggggt  780
gattctgac  ataggaagt  tgcaatgtg  atcactatt  acagagaaa  ctacaacag  840
tgcttgatg  tgtagaaac  gggacatat  gataccaag  aaaattata  gaaacctat  900
aggtgttca  tacgcttgt  tttccaaaa  tcactgtac  tgatcagtt  ggtgttctt  960
taccacagt  tttaactga  ggaaccagt  gtaacagtc  caattttaa  taaaacttg  1020
agaactaaa  caacaatgc  aacctttca  cattgtttg  ccaaacttg  taaaactgt  1080
atgcaagaa  caaatgcac  gtgatgtgg  accaactaa  tagcaagca  gaatttttc  1140
cccaagagt  aaaaaagga  aatctacca  ggcttgaag  taaagagca  aactcctga  1200
taccattct  tgactgatc  aaagactaa  agttaaaaa  ctcagcagg  cttgttcac  1260
atatgcaga  aaaaaagtg  tgcagttta  atacctctg  aatttttcc  cagtgtcac  1320
ggtttgtaa  acttgaagc  ctacatttc  aagaatata  ttcttgctc  gttgtttca  1380
gcaagccca  gactttgta  tttttaaag  gcccaagat  ttttttttt  ttttttttt  1440
aaataacag  ccagcttct  tttcttgca  ttacagatg  aatttcctt  ttgttgtca  1500
acataaggt  ccaaatatg  tgcaataaa  tgttttgaa  aacagttgt  tgaatattt  1560
aactaatct  tgttgggct  ctgtgaaat  cacaggtgg  aacagaggt  caagccaga  1620
gcaatgtaa  atgctgtaa  gctagtgca  atgggagct  tttagaagg  gctaagtgc  1680
ggtgtcagg  aaattccat  atgaagtag  atgctgctc  tgcattaag  tttcattga  1740
ggcaaggct  gtggcaggt  ctatgaatg  aattcataa  ttaaaagga  aactaaaaa  1800
tattttgat  tgggaaaat  agccttaat  tgttaaacc  atacactga  aactagcct  1860
aggcttaat  ttctcattg  atttgcaag  tctgagcaa  taagattaa  taaaacaaa  1920
caattgtat  tataattga  ctttttgtg  aacatgtag  ttatagaaa  tatactcta  1980
agggaattt  ccgaagacc  tttactgat  gaacagttg  gctacaatc  acttttcat  2040
gtacatgac  tgcattcca  atctcagtc  aacagttta  tagtgatgt  aagagaagt  2100
caaaccgaa  tccagtgct  tgttatgtt  tattaactg  ccctgtctc  ggaacatct  2160
aacagatgg  aaaaaaaac  aaaactttt  ttcaactcc  atgagtggc  actgaagtt  2220
ttattgttg  gaaagaaca  tagtcctac  tctgccact  atgaggtgt  tggaggagg  2280
accagccat  taatagggg  tgtatgtgt  aattttgtt  aaactctac  gtatattga  2340
atgaaattc  tttatttgt  ttgacaatg  tcaaatgat  tagattgtc  tagaatgaa  2400
attcataag  actcagaac  cttaagatg  agatgccac  cgtgaggag  taaattcct  2460
atgtgtatt  tattccaac  caattttac  ggaactatt  aataaatct  ttattttct  2520
tcaggttta  ttgatagtg  atacattgg  gtcagagga  cttgactgg  ttcatttta  2580
gtccagaca  cacccctga  acactgtac  gtactatct  gctctgagt  gtatcaact  2640
gatcgtctc  tatttgcct  attcatcct  ttaatttca  atgatactg  gggggaaaa  2700
cagggttag  aaaacaagt  gaaaaaatg  agtgatgtt  taatctaaa  aagtgcctt  2760
tgtttattg  taagaactg  tgttaccaa  ccttttgag  agaaagggt  tcttgacct  2820
tattaacat  ggaaagtaa  gttcttttt  tttttcttt  2859



<210> 7069
<211> 866
<212> PRT
<213> Homo sapiens
<308> CAC43228
<400> 7069

Met Pro Ala Val Ser Leu Pro Pro Lys Glu Asn Ala Leu Phe Lys Arg 
  1               5                  10                  15
Ile Leu Arg Cys Tyr Glu His Lys Gln Tyr Arg Asn Gly Leu Lys Phe 
             20                  25                  30
Cys Lys Gln Ile Leu Ser Asn Pro Lys Phe Ala Glu His Gly Glu Thr 
         35                  40                  45
Leu Ala Met Lys Gly Leu Thr Leu Asn Cys Leu Gly Lys Lys Glu Glu 
     50                  55                  60
Ala Tyr Glu Leu Val Arg Arg Gly Leu Arg Asn Asp Leu Lys Ser His 
 65                  70                  75                  80
Val Cys Trp His Val Tyr Gly Leu Leu Gln Arg Ser Asp Lys Lys Tyr 
                 85                  90                  95
Asp Glu Ala Ile Lys Cys Tyr Arg Asn Ala Leu Lys Trp Asp Lys Asp 
             100                105                110
Asn Leu Gln Ile Leu Arg Asp Leu Ser Leu Leu Gln Ile Gln Met Arg 
         115                120                125
Asp Leu Glu Gly Tyr Arg Glu Thr Arg Tyr Gln Leu Leu Gln Leu Arg 
     130                135                140
Pro Ala Gln Arg Ala Ser Trp Ile Gly Tyr Ala Ile Ala Tyr His Leu 
 145                150                155                160
Leu Glu Asp Tyr Glu Met Ala Ala Lys Ile Leu Glu Glu Phe Arg Lys 
                 165                170                175
Thr Gln Gln Thr Ser Pro Asp Lys Val Asp Tyr Glu Tyr Ser Glu Leu 
             180                185                190
Leu Leu Tyr Gln Asn Gln Val Leu Arg Glu Ala Gly Leu Tyr Arg Glu 
         195                200                205
Ala Leu Glu His Leu Cys Thr Tyr Glu Lys Gln Ile Cys Asp Lys Leu 
     210                215                220
Ala Val Glu Glu Thr Lys Gly Glu Leu Leu Leu Gln Leu Cys Arg Leu 
 225                230                235                240
Glu Asp Ala Ala Asp Val Tyr Arg Gly Leu Gln Glu Arg Asn Pro Glu 
                 245                250                255
Asn Trp Ala Tyr Tyr Lys Gly Leu Glu Lys Ala Leu Lys Pro Ala Asn 
             260                265                270
Met Leu Glu Arg Leu Lys Ile Tyr Glu Glu Ala Trp Thr Lys Tyr Pro 
         275                280                285
Arg Gly Leu Val Pro Arg Arg Leu Pro Leu Asn Phe Leu Ser Gly Glu 
     290                295                300
Lys Phe Lys Glu Cys Leu Asp Lys Phe Leu Arg Met Asn Phe Ser Lys 
 305                310                315                320
Gly Cys Pro Pro Val Phe Asn Thr Leu Arg Ser Leu Tyr Lys Asp Lys 
                 325                330                335
Glu Lys Val Ala Ile Ile Glu Glu Leu Val Val Gly Tyr Glu Thr Ser 
             340                345                350
Leu Lys Ser Cys Arg Leu Phe Asn Pro Asn Asp Asp Gly Lys Glu Glu 
         355                360                365
Pro Pro Thr Thr Leu Leu Trp Val Gln Tyr Tyr Leu Ala Gln His Tyr 
     370                375                380
Asp Lys Ile Gly Gln Pro Ser Ile Ala Leu Glu Tyr Ile Asn Thr Ala 
 385                390                395                400
Ile Glu Ser Thr Pro Thr Leu Ile Glu Leu Phe Leu Val Lys Ala Lys 
                 405                410                415
Ile Tyr Lys His Ala Gly Asn Ile Lys Glu Ala Ala Arg Trp Met Asp 
             420                425                430
Glu Ala Gln Ala Leu Asp Thr Ala Asp Arg Phe Ile Asn Ser Lys Cys 
         435                440                445
Ala Lys Tyr Met Leu Lys Ala Asn Leu Ile Lys Glu Ala Glu Glu Met 
     450                455                460
Cys Ser Lys Phe Thr Arg Glu Gly Thr Ser Ala Val Glu Asn Leu Asn 
 465                470                475                480
Glu Met Gln Cys Met Trp Phe Gln Thr Glu Cys Ala Gln Ala Tyr Lys 
                 485                490                495
Ala Met Asn Lys Phe Gly Glu Ala Leu Lys Lys Cys His Glu Ile Glu 
             500                505                510
Arg His Phe Ile Glu Ile Thr Asp Asp Gln Phe Asp Phe His Thr Tyr 
         515                520                525
Cys Met Arg Lys Ile Thr Leu Arg Ser Tyr Val Asp Leu Leu Lys Leu 
     530                535                540
Glu Asp Val Leu Arg Gln His Pro Phe Tyr Phe Lys Ala Ala Arg Ile 
 545                550                555                560
Ala Ile Glu Ile Tyr Leu Lys Leu His Asp Asn Pro Leu Thr Asp Glu 
                 565                570                575
Asn Lys Glu His Glu Ala Asp Thr Ala Asn Met Ser Asp Lys Glu Leu 
             580                585                590
Lys Lys Leu Arg Asn Lys Gln Arg Arg Ala Gln Lys Lys Ala Gln Ile 
         595                600                605
Glu Glu Glu Lys Lys Asn Ala Glu Lys Glu Lys Gln Gln Arg Asn Gln 
     610                615                620
Lys Lys Lys Lys Asp Asp Asp Asp Glu Glu Ile Gly Gly Pro Lys Glu 
 625                630                635                640
Glu Leu Ile Pro Glu Lys Leu Ala Lys Val Glu Thr Pro Leu Glu Glu 
                 645                650                655
Ala Ile Lys Phe Leu Thr Pro Leu Lys Asn Leu Val Lys Asn Lys Ile 
             660                665                670
Glu Thr His Leu Phe Ala Phe Glu Ile Tyr Phe Arg Lys Glu Lys Phe 
         675                680                685
Leu Leu Met Leu Gln Ser Val Lys Arg Ala Phe Ala Ile Asp Ser Ser 
     690                695                700
His Pro Trp Leu His Glu Cys Met Ile Arg Leu Phe Asn Thr Ala Val 
 705                710                715                720
Cys Glu Ser Lys Asp Leu Ser Asp Thr Val Arg Thr Val Leu Lys Gln 
                 725                730                735
Glu Met Asn Arg Leu Phe Gly Ala Thr Asn Pro Lys Asn Phe Asn Glu 
             740                745                750
Thr Phe Leu Lys Arg Asn Ser Asp Ser Leu Pro His Arg Leu Ser Ala 
         755                760                765
Ala Lys Met Val Tyr Tyr Leu Asp Pro Ser Ser Gln Lys Arg Ala Ile 
     770                775                780
Glu Leu Ala Thr Thr Leu Asp Glu Ser Leu Thr Asn Arg Asn Leu Gln 
 785                790                795                800
Thr Cys Met Glu Val Leu Glu Ala Leu Tyr Asp Gly Ser Leu Gly Asp 
                 805                810                815
Cys Lys Glu Ala Ala Glu Ile Tyr Arg Ala Asn Cys His Lys Leu Phe 
             820                825                830
Pro Tyr Ala Leu Ala Phe Met Pro Pro Gly Tyr Glu Glu Asp Met Lys 
         835                840                845
Ile Thr Val Asn Gly Asp Ser Ser Ala Glu Ala Glu Glu Leu Ala Asn 
     850                855                860
Glu Ile 
 865



<210> 7070
<211> 684
<212> DNA
<213> Rattus norvegicus
<308> AI177404
<400> 7070

ttcaaaaca  tttattgca  catatttgg  accttatgt  tgacaacaa  aaagaaatt  60
catttgtaa  tgcaggaaa  agaagctgg  ctgttattg  aaagaaaaa  cttgggccc  120
ttaaaaatt  caaagtctt  ggcttgcct  aaacaactg  gcaagaaat  tattcttag  180
aatgaaggg  ttcaagtat  acaaacctg  gacactgtg  aaaagttcc  gaggtatct  240
aactgcagc  ctttttctg  atatcgtga  caaggcctg  tgaggtttt  agctattag  300
ctcttgatc  gaatggtag  caggagttc  gctctttaa  ttcaagcca  ggtagagtt  360
ccttttttc  ctctcaggt  aaaaagtca  gcttgctaa  tagttggtg  cacatcaca  420
tgcatttgg  tcttgcatt  cagttttaa  aagtttggc  aaaacaatg  taaagcttt  480
cattgttat  ttagttctt  aagttttag  taaattgag  ttgttccaa  tggttcctt  540
ggttaaaaa  tgtggtaca  gaacaccaa  ctgatcatg  acagtgaat  ttggaaaca  600
aacacacgt  ctgaacacc  tctaggttt  atttaatct  cttggtagc  atgtgtcca  660
gttatctac  acgtcaagc  tctg  684



<210> 7071
<211> 594
<212> PRT
<213> Rattus norvegicus
<308> AAF73953
<400> 7071

Met Leu Glu Arg Leu Lys Ile Tyr Glu Glu Ala Trp Thr Lys Tyr Pro 
  1               5                  10                  15
Arg Gly Leu Val Pro Arg Lys Leu Pro Leu Asn Phe Leu Ser Gly Glu 
             20                  25                  30
Lys Phe Lys Glu Cys Leu Asp Arg Phe Leu Arg Met Asn Phe Ser Lys 
         35                  40                  45
Gly Cys Pro Pro Val Phe Asn Thr Leu Arg Ser Leu Tyr Arg Asp Lys 
     50                  55                  60
Glu Lys Val Ala Ile Val Glu Glu Leu Val Val Gly Tyr Glu Thr Ser 
 65                  70                  75                  80
Leu Lys Ser Cys Arg Leu Phe Asn Pro Asn Asp Asp Gly Lys Glu Glu 
                 85                  90                  95
Pro Pro Thr Thr Leu Leu Trp Val Gln Tyr Tyr Leu Ala Gln His Tyr 
             100                105                110
Asp Lys Ile Gly Gln Pro Ser Ile Ala Leu Glu Tyr Ile Asn Thr Ala 
         115                120                125
Ile Glu Ser Thr Pro Thr Leu Ile Glu Leu Phe Leu Val Lys Ala Lys 
     130                135                140
Ile Tyr Lys His Ala Gly Asn Ile Lys Glu Ala Ala Arg Trp Met Asp 
 145                150                155                160
Glu Ala Gln Ala Leu Asp Thr Ala Asp Arg Phe Ile Asn Ser Lys Cys 
                 165                170                175
Ala Lys Tyr Met Leu Lys Ala Asn Leu Ile Lys Glu Ala Glu Glu Met 
             180                185                190
Cys Ser Lys Phe Thr Arg Glu Gly Thr Ser Ala Val Glu Asn Leu Asn 
         195                200                205
Glu Met Gln Cys Met Trp Phe Gln Thr Glu Cys Ala Gln Ala Tyr Lys 
     210                215                220
Ala Met Asn Lys Phe Gly Glu Ala Leu Lys Lys Cys His Glu Ile Glu 
 225                230                235                240
Arg His Phe Ile Glu Ile Thr Asp Asp Gln Phe Asp Phe His Thr Tyr 
                 245                250                255
Cys Met Arg Lys Ile Thr Leu Arg Ser Tyr Val Asp Leu Leu Lys Leu 
             260                265                270
Glu Asp Val Leu Arg Gln His Pro Phe Tyr Phe Lys Ala Ala Arg Ile 
         275                280                285
Ala Ile Glu Ile Tyr Leu Lys Leu His Asp Asn Pro Leu Thr Asp Glu 
     290                295                300
Asn Lys Glu His Glu Ala Asp Thr Ala Asn Met Ser Asp Lys Glu Leu 
 305                310                315                320
Lys Lys Leu Arg Asn Lys Gln Arg Arg Ala Gln Lys Lys Ala Gln Ile 
                 325                330                335
Glu Glu Glu Lys Lys Asn Ala Glu Lys Glu Lys Pro Gln Arg Asn Pro 
             340                345                350
Lys Lys Lys Lys Asp Asp Asp Asp Glu Glu Ile Gly Gly Pro Lys Glu 
         355                360                365
Glu Leu Ile Pro Glu Lys Leu Ala Lys Val Glu Thr Pro Leu Glu Glu 
     370                375                380
Ala Ile Lys Phe Leu Thr Pro Leu Lys Asn Leu Val Lys Asn Lys Ile 
 385                390                395                400
Glu Thr His Leu Phe Ala Phe Glu Ile Tyr Phe Arg Lys Glu Lys Phe 
                 405                410                415
Leu Leu Met Leu Gln Ser Val Lys Arg Ala Phe Ala Ile Asp Ser Ser 
             420                425                430
His Pro Trp Leu His Glu Cys Met Ile Arg Leu Phe His Ser Val Cys 
         435                440                445
Glu Ser Lys Asp Leu Pro Glu Thr Val Arg Thr Val Leu Lys Gln Glu 
     450                455                460
Met Asn Arg Leu Phe Gly Ala Thr Asn Pro Lys Asn Phe Asn Glu Thr 
 465                470                475                480
Phe Leu Lys Arg Asn Ser Asp Ser Leu Pro His Arg Leu Ser Ala Ala 
                 485                490                495
Lys Met Val Tyr Tyr Leu Asp Ser Ser Ser Gln Lys Arg Ala Ile Glu 
             500                505                510
Leu Ala Thr Thr Leu Asp Gly Ile Pro His Gln Gln Lys Pro Ser Asp 
         515                520                525
Leu His Gly Ser Val Gly Lys Pro Cys Cys Asp Gly Ser Leu Arg Asp 
     530                535                540
Cys Lys Glu Ala Ala Glu Ala Tyr Arg Ala Ser Cys His Lys Leu Phe 
 545                550                555                560
Pro Tyr Ala Leu Ala Phe Met Pro Pro Gly Tyr Glu Glu Asp Met Lys 
                 565                570                575
Ile Thr Val Asn Gly Asp Ser Ser Ala Glu Thr Glu Glu Leu Ala Asn 
             580                585                590
Glu Ile 
         595



<210> 7072
<211> 2859
<212> DNA
<213> Homo sapiens
<308> AK001595
<400> 7072

gattatcag  tgccaaaat  gtatattac  tagatcctt  tagtcagaa  cgagctata  60
agttggcaa  aacacttga  gaatctctc  ctaacagaa  cctccagac  tgtatggag  120
tattggaag  cttgtatga  ggtagccta  gagactgta  agaagctgc  gaaatttat  180
gagcaaatt  tcataagct  ttcccttat  ctttggctt  catgcctcc  ggatatgaa  240
aggatatga  gatcacagt  aatggagat  gttctgcag  agctgaaga  ctggccaat  300
aaatttgaa  atcactaaa  aagcaaatg  aatgacttt  gaccatatc  agtatataa  360
atttttgtc  cgcacctgc  gcattgctc  aacttacac  gaatgagag  agtaaatgt  420
cttgccttc  aatagtgtt  tacgttttt  atcctgctg  aaaagtata  ataaaatat  480
taacattac  ggatagagg  tcagtttct  aaaaaatta  agctgctaa  attgagtgg  540
taaaaaaga  accttatcc  attcctccc  acccaccca  gtttttaaa  taatttata  600
aaaatctgg  ggctgttac  gctaacaaa  caggtgtgt  gcagaaata  tactttaaa  660
ttgtcttgt  agattttac  atatctcag  cagcataaa  gctgtttta  cactggatt  720
tttcactga  cacaaagag  tgttggggc  ttagcatct  actgatttt  ttacggggt  780
gattctgac  ataggaagt  tgcaatgtg  atcactatt  acagagaaa  ctacaacag  840
tgcttgatg  tgtagaaac  gggacatat  gataccaag  aaaattata  gaaacctat  900
aggtgttca  tacgcttgt  tttccaaaa  tcactgtac  tgatcagtt  ggtgttctt  960
taccacagt  tttaactga  ggaaccagt  gtaacagtc  caattttaa  taaaacttg  1020
agaactaaa  caacaatgc  aacctttca  cattgtttg  ccaaacttg  taaaactgt  1080
atgcaagaa  caaatgcac  gtgatgtgg  accaactaa  tagcaagca  gaatttttc  1140
cccaagagt  aaaaaagga  aatctacca  ggcttgaag  taaagagca  aactcctga  1200
taccattct  tgactgatc  aaagactaa  agttaaaaa  ctcagcagg  cttgttcac  1260
atatgcaga  aaaaaagtg  tgcagttta  atacctctg  aatttttcc  cagtgtcac  1320
ggtttgtaa  acttgaagc  ctacatttc  aagaatata  ttcttgctc  gttgtttca  1380
gcaagccca  gactttgta  tttttaaag  gcccaagat  ttttttttt  ttttttttt  1440
aaataacag  ccagcttct  tttcttgca  ttacagatg  aatttcctt  ttgttgtca  1500
acataaggt  ccaaatatg  tgcaataaa  tgttttgaa  aacagttgt  tgaatattt  1560
aactaatct  tgttgggct  ctgtgaaat  cacaggtgg  aacagaggt  caagccaga  1620
gcaatgtaa  atgctgtaa  gctagtgca  atgggagct  tttagaagg  gctaagtgc  1680
ggtgtcagg  aaattccat  atgaagtag  atgctgctc  tgcattaag  tttcattga  1740
ggcaaggct  gtggcaggt  ctatgaatg  aattcataa  ttaaaagga  aactaaaaa  1800
tattttgat  tgggaaaat  agccttaat  tgttaaacc  atacactga  aactagcct  1860
aggcttaat  ttctcattg  atttgcaag  tctgagcaa  taagattaa  taaaacaaa  1920
caattgtat  tataattga  ctttttgtg  aacatgtag  ttatagaaa  tatactcta  1980
agggaattt  ccgaagacc  tttactgat  gaacagttg  gctacaatc  acttttcat  2040
gtacatgac  tgcattcca  atctcagtc  aacagttta  tagtgatgt  aagagaagt  2100
caaaccgaa  tccagtgct  tgttatgtt  tattaactg  ccctgtctc  ggaacatct  2160
aacagatgg  aaaaaaaac  aaaactttt  ttcaactcc  atgagtggc  actgaagtt  2220
ttattgttg  gaaagaaca  tagtcctac  tctgccact  atgaggtgt  tggaggagg  2280
accagccat  taatagggg  tgtatgtgt  aattttgtt  aaactctac  gtatattga  2340
atgaaattc  tttatttgt  ttgacaatg  tcaaatgat  tagattgtc  tagaatgaa  2400
attcataag  actcagaac  cttaagatg  agatgccac  cgtgaggag  taaattcct  2460
atgtgtatt  tattccaac  caattttac  ggaactatt  aataaatct  ttattttct  2520
tcaggttta  ttgatagtg  atacattgg  gtcagagga  cttgactgg  ttcatttta  2580
gtccagaca  cacccctga  acactgtac  gtactatct  gctctgagt  gtatcaact  2640
gatcgtctc  tatttgcct  attcatcct  ttaatttca  atgatactg  gggggaaaa  2700
cagggttag  aaaacaagt  gaaaaaatg  agtgatgtt  taatctaaa  aagtgcctt  2760
tgtttattg  taagaactg  tgttaccaa  ccttttgag  agaaagggt  tcttgacct  2820
tattaacat  ggaaagtaa  gttcttttt  tttttcttt  2859



<210> 7073
<211> 866
<212> PRT
<213> Homo sapiens
<308> CAC43228
<400> 7073

Met Pro Ala Val Ser Leu Pro Pro Lys Glu Asn Ala Leu Phe Lys Arg 
  1               5                  10                  15
Ile Leu Arg Cys Tyr Glu His Lys Gln Tyr Arg Asn Gly Leu Lys Phe 
             20                  25                  30
Cys Lys Gln Ile Leu Ser Asn Pro Lys Phe Ala Glu His Gly Glu Thr 
         35                  40                  45
Leu Ala Met Lys Gly Leu Thr Leu Asn Cys Leu Gly Lys Lys Glu Glu 
     50                  55                  60
Ala Tyr Glu Leu Val Arg Arg Gly Leu Arg Asn Asp Leu Lys Ser His 
 65                  70                  75                  80
Val Cys Trp His Val Tyr Gly Leu Leu Gln Arg Ser Asp Lys Lys Tyr 
                 85                  90                  95
Asp Glu Ala Ile Lys Cys Tyr Arg Asn Ala Leu Lys Trp Asp Lys Asp 
             100                105                110
Asn Leu Gln Ile Leu Arg Asp Leu Ser Leu Leu Gln Ile Gln Met Arg 
         115                120                125
Asp Leu Glu Gly Tyr Arg Glu Thr Arg Tyr Gln Leu Leu Gln Leu Arg 
     130                135                140
Pro Ala Gln Arg Ala Ser Trp Ile Gly Tyr Ala Ile Ala Tyr His Leu 
 145                150                155                160
Leu Glu Asp Tyr Glu Met Ala Ala Lys Ile Leu Glu Glu Phe Arg Lys 
                 165                170                175
Thr Gln Gln Thr Ser Pro Asp Lys Val Asp Tyr Glu Tyr Ser Glu Leu 
             180                185                190
Leu Leu Tyr Gln Asn Gln Val Leu Arg Glu Ala Gly Leu Tyr Arg Glu 
         195                200                205
Ala Leu Glu His Leu Cys Thr Tyr Glu Lys Gln Ile Cys Asp Lys Leu 
     210                215                220
Ala Val Glu Glu Thr Lys Gly Glu Leu Leu Leu Gln Leu Cys Arg Leu 
 225                230                235                240
Glu Asp Ala Ala Asp Val Tyr Arg Gly Leu Gln Glu Arg Asn Pro Glu 
                 245                250                255
Asn Trp Ala Tyr Tyr Lys Gly Leu Glu Lys Ala Leu Lys Pro Ala Asn 
             260                265                270
Met Leu Glu Arg Leu Lys Ile Tyr Glu Glu Ala Trp Thr Lys Tyr Pro 
         275                280                285
Arg Gly Leu Val Pro Arg Arg Leu Pro Leu Asn Phe Leu Ser Gly Glu 
     290                295                300
Lys Phe Lys Glu Cys Leu Asp Lys Phe Leu Arg Met Asn Phe Ser Lys 
 305                310                315                320
Gly Cys Pro Pro Val Phe Asn Thr Leu Arg Ser Leu Tyr Lys Asp Lys 
                 325                330                335
Glu Lys Val Ala Ile Ile Glu Glu Leu Val Val Gly Tyr Glu Thr Ser 
             340                345                350
Leu Lys Ser Cys Arg Leu Phe Asn Pro Asn Asp Asp Gly Lys Glu Glu 
         355                360                365
Pro Pro Thr Thr Leu Leu Trp Val Gln Tyr Tyr Leu Ala Gln His Tyr 
     370                375                380
Asp Lys Ile Gly Gln Pro Ser Ile Ala Leu Glu Tyr Ile Asn Thr Ala 
 385                390                395                400
Ile Glu Ser Thr Pro Thr Leu Ile Glu Leu Phe Leu Val Lys Ala Lys 
                 405                410                415
Ile Tyr Lys His Ala Gly Asn Ile Lys Glu Ala Ala Arg Trp Met Asp 
             420                425                430
Glu Ala Gln Ala Leu Asp Thr Ala Asp Arg Phe Ile Asn Ser Lys Cys 
         435                440                445
Ala Lys Tyr Met Leu Lys Ala Asn Leu Ile Lys Glu Ala Glu Glu Met 
     450                455                460
Cys Ser Lys Phe Thr Arg Glu Gly Thr Ser Ala Val Glu Asn Leu Asn 
 465                470                475                480
Glu Met Gln Cys Met Trp Phe Gln Thr Glu Cys Ala Gln Ala Tyr Lys 
                 485                490                495
Ala Met Asn Lys Phe Gly Glu Ala Leu Lys Lys Cys His Glu Ile Glu 
             500                505                510
Arg His Phe Ile Glu Ile Thr Asp Asp Gln Phe Asp Phe His Thr Tyr 
         515                520                525
Cys Met Arg Lys Ile Thr Leu Arg Ser Tyr Val Asp Leu Leu Lys Leu 
     530                535                540
Glu Asp Val Leu Arg Gln His Pro Phe Tyr Phe Lys Ala Ala Arg Ile 
 545                550                555                560
Ala Ile Glu Ile Tyr Leu Lys Leu His Asp Asn Pro Leu Thr Asp Glu 
                 565                570                575
Asn Lys Glu His Glu Ala Asp Thr Ala Asn Met Ser Asp Lys Glu Leu 
             580                585                590
Lys Lys Leu Arg Asn Lys Gln Arg Arg Ala Gln Lys Lys Ala Gln Ile 
         595                600                605
Glu Glu Glu Lys Lys Asn Ala Glu Lys Glu Lys Gln Gln Arg Asn Gln 
     610                615                620
Lys Lys Lys Lys Asp Asp Asp Asp Glu Glu Ile Gly Gly Pro Lys Glu 
 625                630                635                640
Glu Leu Ile Pro Glu Lys Leu Ala Lys Val Glu Thr Pro Leu Glu Glu 
                 645                650                655
Ala Ile Lys Phe Leu Thr Pro Leu Lys Asn Leu Val Lys Asn Lys Ile 
             660                665                670
Glu Thr His Leu Phe Ala Phe Glu Ile Tyr Phe Arg Lys Glu Lys Phe 
         675                680                685
Leu Leu Met Leu Gln Ser Val Lys Arg Ala Phe Ala Ile Asp Ser Ser 
     690                695                700
His Pro Trp Leu His Glu Cys Met Ile Arg Leu Phe Asn Thr Ala Val 
 705                710                715                720
Cys Glu Ser Lys Asp Leu Ser Asp Thr Val Arg Thr Val Leu Lys Gln 
                 725                730                735
Glu Met Asn Arg Leu Phe Gly Ala Thr Asn Pro Lys Asn Phe Asn Glu 
             740                745                750
Thr Phe Leu Lys Arg Asn Ser Asp Ser Leu Pro His Arg Leu Ser Ala 
         755                760                765
Ala Lys Met Val Tyr Tyr Leu Asp Pro Ser Ser Gln Lys Arg Ala Ile 
     770                775                780
Glu Leu Ala Thr Thr Leu Asp Glu Ser Leu Thr Asn Arg Asn Leu Gln 
 785                790                795                800
Thr Cys Met Glu Val Leu Glu Ala Leu Tyr Asp Gly Ser Leu Gly Asp 
                 805                810                815
Cys Lys Glu Ala Ala Glu Ile Tyr Arg Ala Asn Cys His Lys Leu Phe 
             820                825                830
Pro Tyr Ala Leu Ala Phe Met Pro Pro Gly Tyr Glu Glu Asp Met Lys 
         835                840                845
Ile Thr Val Asn Gly Asp Ser Ser Ala Glu Ala Glu Glu Leu Ala Asn 
     850                855                860
Glu Ile 
 865



<210> 7074
<211> 434
<212> DNA
<213> Rattus norvegicus
<308> AI177683
<400> 7074

ttttttttt  aaaagttaa  aattcctta  ttttttatt  ctggtacca  taccacaat  60
tacagggca  tatacctga  gtaatgaaa  gaaaaagaa  aagacaaag  tacaacaga  120
aaaagacct  aggaatgta  atctaattg  cactacatt  cattaatcg  tagctgcac  180
tttgcaaac  gtggctatg  cagtcctga  caagaaggg  ttcctgttt  agctgcagt  240
acttttctg  ctatggatc  tcgttcctt  tgtggcaga  ttttacagt  cctctaatg  300
atttaggac  actgtctca  agtaacctg  agctttcct  acaactcct  gctctctct  360
ctgctaaga  ctgtagccg  ttgttttat  ttaaaacct  ctgctacca  atccaccac  420
tccaccctc  tgcc  434



<210> 7075
<211> 193
<212> PRT
<213> Rattus norvegicus
<308> CAA76339
<400> 7075

Lys Tyr His Thr Ile Asn Gly His Asn Cys Glu Val Lys Lys Ala Leu 
  1               5                  10                  15
Ser Lys Gln Glu Met Gln Ser Ala Gly Ser Gln Arg Gly Arg Gly Gly 
             20                  25                  30
Gly Ser Gly Asn Phe Met Gly Arg Gly Gly Asn Phe Gly Gly Gly Gly 
         35                  40                  45
Gly Asn Phe Gly Arg Gly Gly Asn Phe Gly Gly Arg Gly Gly Tyr Gly 
     50                  55                  60
Gly Gly Gly Gly Gly Ser Arg Gly Ser Tyr Gly Gly Gly Asp Gly Gly 
 65                  70                  75                  80
Tyr Asn Gly Phe Gly Gly Asp Gly Gly Asn Tyr Gly Gly Gly Pro Gly 
                 85                  90                  95
Tyr Ser Ser Arg Gly Gly Tyr Gly Gly Gly Gly Pro Gly Tyr Gly Asn 
             100                105                110
Gln Gly Gly Gly Tyr Gly Gly Gly Gly Gly Gly Tyr Asp Gly Tyr Asn 
         115                120                125
Glu Gly Gly Asn Phe Gly Gly Gly Asn Tyr Gly Gly Gly Gly Asn Tyr 
     130                135                140
Asn Asp Phe Gly Asn Tyr Ser Gly Gln Gln Gln Ser Asn Tyr Gly Pro 
 145                150                155                160
Met Lys Gly Gly Ser Phe Gly Gly Arg Ser Ser Gly Ser Pro Tyr Gly 
                 165                170                175
Gly Gly Tyr Gly Ser Gly Gly Gly Ser Gly Gly Tyr Gly Ser Arg Arg 
             180                185                190
Phe 
         195



<210> 7076
<211> 178
<212> DNA
<213> Homo sapiens
<308> AW383404
<400> 7076

aatgagacg  tggcttgta  ttttgatga  catgataca  ttgataaaa  tgttgttca  60
aaataccac  ctattaatg  gcataattg  gaagtgaaa  aggcccttt  taaacaaga  120
atgcagtct  ctggatcac  gagaggtcg  ggaggtgga  ctggattca  ataggagg  178



<210> 7077
<211> 379
<212> PRT
<213> Homo sapiens
<308> P51991
<400> 7077

Met Glu Val Lys Pro Pro Pro Gly Cys Pro Gln Pro Asp Ser Gly Ser 
  1               5                  10                  15
Arg Arg Arg Arg Trp Gly Glu Glu Gly His Asp Pro Lys Glu Pro Glu 
             20                  25                  30
Gln Leu Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp 
         35                  40                  45
Asp Ser Leu Arg Glu His Phe Glu Lys Trp Gly Thr Leu Thr Asp Cys 
     50                  55                  60
Leu Val Met Arg Asp Pro Gln Thr Lys Arg Ser Arg Gly Phe Gly Phe 
 65                  70                  75                  80
Val Thr Tyr Ser Cys Val Thr Glu Val Asp Ala Ala Ile Gly Ala Arg 
                 85                  90                  95
Pro Phe Lys Val Asp Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser 
             100                105                110
Arg Glu Asp Ser Val Lys Pro Gly Ala His Leu Thr Val Lys Lys Ile 
         115                120                125
Phe Val Gly Ser Ile Lys Glu Asp Thr Glu Glu Tyr Asn Leu Arg Asp 
     130                135                140
Tyr Phe Glu Lys Tyr Gly Lys Ile Glu Thr Ile Glu Val Met Glu Asp 
 145                150                155                160
Arg Gln Ser Gly Lys Lys Arg Gly Phe Ala Ser Val Thr Phe Asp Asp 
                 165                170                175
His Asp Thr Val Asp Lys Ile Val Val Gln Lys Tyr His Thr Ile Asn 
             180                185                190
Gly His Asn Cys Glu Val Lys Lys Ala Leu Ala Lys Gln Val Met Gln 
         195                200                205
Pro Ala Gly Ser Gln Arg Gly Arg Gly Gly Gly Ser Gly Asn Cys Met 
     210                215                220
Gly His Arg Gly Asn Phe Gly Gly Gly Gly Gly Asn Phe Gly Arg Asp 
 225                230                235                240
Gly Asn Phe Gly Gly Arg Gly Gly Tyr Gly Gly Gly Gly Gly Gly Ser 
                 245                250                255
Arg Gly Ser Tyr Gly Gly Gly Asp Gly Gly Tyr Asn Gly Leu Gly Gly 
             260                265                270
Asp Gly Gly Asn Tyr Gly Ser Gly Pro Gly Tyr Ser Ser Arg Gly Gly 
         275                280                285
Tyr Gly Gly Gly Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly 
     290                295                300
Gly Gly Val Gly Gly Tyr Asp Gly Tyr Asn Glu Gly Gly Asn Phe Asp 
 305                310                315                320
Gly Ser Asn Tyr Gly Gly Gly Gly Asn Tyr Asn Asp Phe Gly Asn Tyr 
                 325                330                335
Ser Gly Gln Gln Gln Ser Asn Tyr Gly His Met Lys Gly Gly Ser Phe 
             340                345                350
Gly Gly Arg Ser Ser Gly Ser Pro Tyr Gly Gly Gly Tyr Gly Ser Gly 
         355                360                365
Gly Gly Ser Gly Gly Tyr Gly Ser Arg Arg Phe 
     370                375



<210> 7078
<211> 696
<212> DNA
<213> Rattus norvegicus
<308> AI177751
<400> 7078

gcacttaaa  aatactgca  tttatcaaa  aacacataa  aaatttcaa  tcttattct  60
tgagttaca  aaatcaagg  tcggctaag  tataaacat  tttttcatg  aattatttg  120
ataattcta  taatgctca  tggcttaag  tcagaactg  ttcttaaaa  aacactaaa  180
acataaaaa  ccttagccc  tgtatttac  tgtagaata  attcattta  gcttacatt  240
caggatttg  tatatcagg  ataacttta  aggtcacat  caaaggaga  agcaaacca  300
ctataaact  gcattattt  tttattttt  ggcttgtga  acttcctta  tttgttgat  360
tagcaaaca  atttcaact  tgctatgca  atgacagaa  aaatctgct  agcgattca  420
tttagagtt  agcttcata  aggcaacat  ctacatgtg  aaaattact  actgaacta  480
aggtattaa  tactgaaaa  aattaacag  ttattataa  ttattttat  taacaatct  540
ggaagttcg  ggccatcag  agttccagt  caatttcag  tgcaattgg  aattcagga  600
tttcagtgg  gctgttagt  tagcggacc  tgtaggtaa  atacatgca  actttcgat  660
gcacatgtg  agggatctc  ctaaagttg  cctcat  696



<210> 7079
<211> 536
<212> DNA
<213> Rattus norvegicus
<308> AI177986
<400> 7079

atgagttta  ctttctctt  aaataagac  atcagggaa  gggatcaag  ttgaaaaac  60
gtaacactt  ttttggcaa  atagcaacc  aaatctaaa  tacaagcta  tatatccaa  120
ttaaaaggc  ttaaagaat  aaccataat  ttagggagg  ggaacacat  aaacacaag  180
tacagtatg  ctaaacatc  tgaaattat  atttaaggg  aaaagttga  aacttatgc  240
gttttagat  aagtgcacc  ttttcctgt  tctcccaaa  agaatcaga  tttacgatt  300
aatcacacc  caaagcttt  ctctcagta  aaagcaacc  ctaaataca  acaaaatac  360
tatttgtca  ttccctggc  tatccaacg  gcaatgcac  tgactcaat  gactacaat  420
tggggtgag  gtacacaaa  tgaaaaacc  caactccaa  tttcaaaat  tgctcttaa  480
ccataggac  cacaggtca  ttttacttc  catgaggat  tcacactgt  attaaa  536



<210> 7080
<211> 429
<212> PRT
<213> Rattus norvegicus
<308> Q07205
<400> 7080

Met Ser Val Asn Val Asn Arg Ser Val Ser Asp Gln Phe Tyr Arg Tyr 
  1               5                  10                  15
Lys Met Pro Arg Leu Ile Ala Lys Val Glu Gly Lys Gly Asn Gly Ile 
             20                  25                  30
Lys Thr Val Ile Val Asn Met Val Asp Val Ala Lys Ala Leu Asn Arg 
         35                  40                  45
Pro Pro Thr Tyr Pro Thr Lys Tyr Phe Gly Cys Glu Leu Gly Ala Gln 
     50                  55                  60
Thr Gln Phe Asp Val Lys Asn Asp Arg Tyr Ile Val Asn Gly Ser His 
 65                  70                  75                  80
Glu Ala Asn Lys Leu Gln Asp Met Leu Asp Gly Phe Ile Lys Lys Phe 
                 85                  90                  95
Val Leu Cys Pro Glu Cys Glu Asn Pro Glu Thr Asp Leu His Val Asn 
             100                105                110
Pro Lys Lys Gln Thr Ile Gly Asn Ser Cys Lys Ala Cys Gly Tyr Arg 
         115                120                125
Gly Met Leu Asp Thr His His Lys Leu Cys Thr Phe Ile Leu Lys Asn 
     130                135                140
Pro Pro Glu Asn Ser Asp Ile Gly Thr Gly Lys Lys Glu Lys Glu Lys 
 145                150                155                160
Lys Asn Arg Lys Gly Lys Asp Lys Glu Asn Gly Ser Val Ser Thr Ser 
                 165                170                175
Glu Thr Pro Pro Pro Pro Pro Pro Asn Glu Ile Ser Pro Pro His Ala 
             180                185                190
Val Glu Glu Glu Glu Asp Asp Asp Trp Gly Glu Asp Thr Thr Glu Glu 
         195                200                205
Ala Gln Arg Arg Arg Met Asp Glu Ile Ser Asp His Ala Lys Gly Leu 
     210                215                220
Thr Leu Ser Asp Asp Leu Glu Arg Thr Val Glu Glu Arg Val Asn Ile 
 225                230                235                240
Leu Phe Asp Phe Val Lys Lys Lys Lys Glu Glu Gly Ile Ile Asp Ser 
                 245                250                255
Ser Asp Lys Asp Ile Val Ala Glu Ala Glu Arg Leu Asp Val Lys Ala 
             260                265                270
Met Gly Pro Leu Val Leu Thr Glu Val Leu Phe Asp Glu Lys Ile Arg 
         275                280                285
Glu Gln Ile Lys Lys Tyr Arg Arg His Phe Leu Arg Phe Cys His Asn 
     290                295                300
Asn Lys Lys Ala Gln Arg Tyr Leu Leu His Gly Leu Glu Cys Val Val 
 305                310                315                320
Ala Met His Gln Ala Gln Leu Ile Ser Lys Ile Pro His Ile Leu Lys 
                 325                330                335
Glu Met Tyr Asp Ala Asp Leu Leu Glu Glu Glu Val Ile Ile Ser Trp 
             340                345                350
Ser Glu Lys Ala Ser Lys Lys Tyr Val Ser Lys Glu Leu Ala Lys Glu 
         355                360                365
Ile Arg Val Lys Ala Glu Pro Phe Ile Lys Trp Leu Lys Glu Ala Glu 
     370                375                380
Glu Glu Ser Ser Gly Gly Glu Glu Glu Asp Glu Asp Glu Asn Ile Glu 
 385                390                395                400
Val Val Tyr Ser Lys Thr Ala Ser Val Pro Lys Val Glu Thr Val Lys 
                 405                410                415
Ser Asp Asn Lys Asp Asp Asp Ile Asp Ile Asp Ala Ile 
             420                425



<210> 7081
<211> 3899
<212> DNA
<213> Homo sapiens
<308> NM_001969
<400> 7081

agcttgagc  cggcggcgg  gttgttcag  cagagcgag  acattccag  ggtcgccca  60
ctccggcgc  gacgggtgt  gaccgcgga  gtcgctggg  cagcccctc  ccgctgctc  120
gcggcggca  ctggcccgg  cgctcctcg  tgcgcttcg  ctccgcctc  tcggactcg  180
actcgggtt  atatcgcgc  tcacttcat  ccagtcccg  gcgagcagc  ttgggttta  240
gtctttatt  gacgaaaac  agctgttgc  cagccattg  tacctgtat  ggggaaaca  300
agcatacaa  caagaagct  acagcctca  tggcgaaaa  tttttcatg  cagagaccg  360
gaactcttg  agtcgttta  gtcatccct  cttctccag  cagaagata  caaaaagtt  420
caatcaaag  tctcttcat  ttattgata  agccactaa  aagccaaaa  gtctgtcaa  480
gtcaaccgc  gcgtgtcag  ccagttcta  cgctacaag  tgccccgtc  gattgccaa  540
gttgagggc  aaggcaatg  aatcaagac  gttatagtc  acatggttg  cgttgcaaa  600
gcgcttaat  ggcctccaa  gtatcccac  aaatatttt  gttgtgagc  gggagcaca  660
acccagttt  atgttaaga  tgaccgtta  attgtcaat  gatctcatg  ggcgaataa  720
ctgcaagac  tgttggatg  attcattaa  aaatttgtt  tctgtcctg  atgtgagaa  780
cctgaaaca  atttgcatg  caatccaaa  aagcaaaca  taggtaatt  ttgtaaagc  840
tgtggctat  gaggcatgc  tgacacaca  cataaactc  gcacattca  tctcaaaaa  900
ccacctgag  atagtgaca  tggtacagg  aagaaagaa  aagaaaaga  aaacagaaa  960
ggcaaagac  aggaaaatg  ctccgtatc  agcagtgag  caccaccac  accaccacc  1020
ccaaatgaa  ttaatcctc  tccacatac  atggaagaa  aggaggatg  tgactgggg  1080
gaagataca  ctgaggaag  tcaaaggcg  cgaatggat  aaatcagtg  ccatgcaaa  1140
gttctgaca  tcagtgatg  tttggaaag  acaattgag  agagggtca  tatcctctt  1200
gattttgtt  agaaaaaga  agaagaggg  gttattgat  catctgaca  agaaatcgt  1260
gctgaagca  aaagactgg  tgtaaaagc  atgggccct  ttgttctaa  tgaagttct  1320
tttaatgag  agattagag  acagattaa  aaatacagg  gccatttcc  acgattttg  1380
cacaacaac  aaaaagccc  acggtacct  cttcatggt  tggagtgtg  ggtagcaat  1440
catcaagct  agcttatct  caagattcc  catatcttg  aggagatgt  cgatgcaga  1500
cttttagaa  aagaggtca  catcagctg  tcggaaaag  cctctaaga  atatgtctc  1560
aaagaactt  ccaaagaga  tcgtgtcaa  gcagaacca  ttataaaat  gttgaagga  1620
gcagaggaa  aatcttctg  tggcgaaga  gaagatgaa  atgagaaca  tgaggtggt  1680
tattcgaag  ctgccagtg  accgaaagt  gagactgta  agtcagaca  caaggatga  1740
gacatcgat  ttgatgcca  ttaaaggga  ggatgcaac  tagcttaac  gtataatgc  1800
gcaaatttt  ctccattat  agccagaag  gcaacatgt  tgtgcaaaa  ctaaaatgg  1860
ttaacatca  gctacactt  acactaaaa  tctattact  tgagtggtc  gttattaag  1920
ccaatgaga  atctaggga  tccatacac  tcagtgagc  gatgtagtt  gcttattta  1980
agcatgttt  tttttgaaa  actagtggt  gacacattt  gatcacatt  atacagtta  2040
aaaaataaa  gtttgattt  ggtcgttct  cagatgttt  gctctgaat  acttaagct  2100
aagtaactg  ctccttact  taaatgttc  gccatcatt  cacctgatg  gcattcttg  2160
agcctgcca  atattgtta  gtcctgggg  tgcaaagag  tcctcaaca  gatgtaaag  2220
aaacttaat  gtaattaat  tattcagcc  attaagaaa  tactaaagt  ttatctctg  2280
agttcctca  attggcatc  ggtaatgta  attgtgagg  agactgata  tgaaatgac  2340
gtgcaacat  ttaaccaag  agtaaatat  acctcagtg  cctataaat  atgtaagag  2400
aggatttga  acttggaga  ctgttttct  atttcatgt  cacttgccc  aaattgtct  2460
tgaagtcgt  tgcattgca  gttggatga  ccagggaaa  tattacatt  acaagcatt  2520
tgtgtgtgc  tagtagtta  tttgtactg  gagaacttg  tttggggtg  aattaaaca  2580
taaactgat  ttatttggg  gaaacaagg  agggtgcac  taactagca  cctaagcat  2640
atttttcag  ttttgccct  agggtttaa  ttacaattc  aaaatgtta  acatactgt  2700
ttttttcgt  cagtgtggc  ttaattttc  cctcttgca  tttgttctg  aatgccttt  2760
acatttgga  acatagttt  tgcttttta  attttggtt  ctttcttgc  aaaataagt  2820
ttaactgtg  ttcaaactt  attttcttt  ttttttctt  ttttttctt  cagaatgtc  2880
tatttaaaa  gaaagctaa  agcatactt  taagtcaga  cctctattt  ggtgtaaga  2940
ttgggatat  ttttacttc  cattgaata  agccaggca  ccaagaagt  tgatggcca  3000
ctgagtgca  gtgacaagg  cctgacaga  cccatgcag  gctttagat  tggacacac  3060
agagttgat  acttcctca  gaactcctt  cctgatcta  actcatatt  tgggttctg  3120
ctgtttgag  aatcgtctt  aaggttaaa  ctcttggca  ttacccttt  cacaaagtg  3180
acagtggga  tcgagaatc  atagggtta  ttttggagc  gtggcttat  ccattcacc  3240
ctgtttttt  gtgattatt  cacagataa  gagacctta  taacaaata  gcgtaaaaa  3300
attttcaca  tgaaatgat  gaaacattt  atgtaataa  acttggttg  cttgatatt  3360
taaggaatt  aaacctagc  atcttattg  agagacaag  attggtctc  agctgcctt  3420
gatcaagat  cgggtgcaa  tggagcagg  gccatatac  tggagggaa  gtgctttgt  3480
acaccaaag  ggatttttt  tttcttcaa  cttgtatgt  gcctaggtt  caaattctt  3540
gccgcaagg  tgatctgct  tcattaact  gaattctgt  ggagatact  gtgacctaa  3600
ctaagttgc  ctcagcata  tcagtgtca  gctaatgag  ttctattat  aaggttcta  3660
ttttaatct  agggaaaac  tgttcaggg  ttctagaac  ctaaaaaat  tggcttaaa  3720
cagtgttca  tctggtgcc  aacttcgaa  ggaatacaa  ttcacataa  ctgaacttt  3780
ttcacaggt  atcctaata  agtaattct  cactttgct  tattgaact  tcttaagga  3840
ttgtttaaa  agctaagtt  cttgattaa  ataatgata  aattgtaaa  aaaaaaaaa  3899



<210> 7082
<211> 431
<212> PRT
<213> Homo sapiens
<308> P55010
<400> 7082

Met Ser Val Asn Val Asn Arg Ser Val Ser Asp Gln Phe Tyr Arg Tyr 
  1               5                  10                  15
Lys Met Pro Arg Leu Ile Ala Lys Val Glu Gly Lys Gly Asn Gly Ile 
             20                  25                  30
Lys Thr Val Ile Val Asn Met Val Asp Val Ala Lys Ala Leu Asn Arg 
         35                  40                  45
Pro Pro Thr Tyr Pro Thr Lys Tyr Phe Gly Cys Glu Leu Gly Ala Gln 
     50                  55                  60
Thr Gln Phe Asp Val Lys Asn Asp Arg Tyr Ile Val Asn Gly Ser His 
 65                  70                  75                  80
Glu Ala Asn Lys Leu Gln Asp Met Leu Asp Gly Phe Ile Lys Lys Phe 
                 85                  90                  95
Val Leu Cys Pro Glu Cys Glu Asn Pro Glu Thr Asp Leu His Val Asn 
             100                105                110
Pro Lys Lys Gln Thr Ile Gly Asn Ser Cys Lys Ala Cys Gly Tyr Arg 
         115                120                125
Gly Met Leu Asp Thr His His Lys Leu Cys Thr Phe Ile Leu Lys Asn 
     130                135                140
Pro Pro Glu Asn Ser Asp Ser Gly Thr Gly Lys Lys Glu Lys Glu Lys 
 145                150                155                160
Lys Asn Arg Lys Gly Lys Asp Lys Glu Asn Gly Ser Val Ser Ser Ser 
                 165                170                175
Glu Thr Pro Pro Pro Pro Pro Pro Pro Asn Glu Ile Asn Pro Pro Pro 
             180                185                190
His Thr Met Glu Glu Glu Glu Asp Asp Asp Ser Gly Glu Asp Thr Thr 
         195                200                205
Glu Glu Ala Gln Arg Arg Arg Met Asp Glu Ile Ser Asp His Ala Lys 
     210                215                220
Val Leu Thr Leu Ser Asp Asp Leu Glu Arg Thr Ile Glu Glu Arg Val 
 225                230                235                240
Asn Ile Leu Phe Asp Phe Val Lys Lys Lys Lys Glu Glu Gly Val Ile 
                 245                250                255
Asp Ser Ser Asp Lys Glu Ile Val Ala Glu Ala Glu Arg Leu Asp Val 
             260                265                270
Lys Ala Met Gly Pro Leu Val Leu Thr Glu Val Leu Phe Asn Glu Lys 
         275                280                285
Ile Arg Glu Gln Ile Lys Lys Tyr Arg Arg His Phe Leu Arg Phe Cys 
     290                295                300
His Asn Asn Lys Lys Ala Gln Arg Tyr Leu Leu His Gly Leu Glu Cys 
 305                310                315                320
Val Val Ala Met His Gln Ala Gln Leu Ile Ser Lys Ile Pro His Ile 
                 325                330                335
Leu Lys Glu Met Tyr Asp Ala Asp Leu Leu Glu Glu Glu Val Ile Ile 
             340                345                350
Ser Trp Ser Glu Lys Ala Ser Lys Lys Tyr Val Ser Lys Glu Leu Ala 
         355                360                365
Lys Glu Ile Arg Val Lys Ala Glu Pro Phe Ile Lys Trp Leu Lys Glu 
     370                375                380
Ala Glu Glu Glu Ser Ser Gly Gly Glu Glu Glu Asp Glu Asp Glu Asn 
 385                390                395                400
Ile Glu Val Val Tyr Ser Lys Ala Ala Ser Val Pro Lys Val Glu Thr 
                 405                410                415
Val Lys Ser Asp Asn Lys Asp Asp Asp Ile Asp Ile Asp Ala Ile 
             420                425                430



<210> 7083
<211> 578
<212> DNA
<213> Rattus norvegicus
<308> AI178135
<400> 7083

agatgaagt  agatttatt  ttcatcatc  tgtcataca  aaatctaca  ataatagat  60
tgtacagga  aagagccca  aggaatagt  aatggaggt  taacggcga  aatttaaac  120
tgctttccc  catatatta  gatgacagc  atttcaaag  atagttgtg  tgtcaaggc  180
gcttttgct  gcccaccag  gctggccgt  tagattgag  ccttcagtc  cacagttct  240
ctgactctt  acaaagctt  tgaggtcct  aagaaaggt  atatattcc  ggtgctcca  300
ggctgtgct  agctccacc  actcatctg  aaaagtgtt  tccacccct  ggtccgcaa  360
gaaatccat  aggtggtca  acaaggccc  gtccaggga  tctgtgttg  gtgtgtagt  420
tgtatccct  cactcagag  caccagtgg  ctgaaagct  acttcctta  tagagaaaa  480
gtcactctc  gcctcatct  cgtgtccga  ctcgtcctc  ggatagtgg  agtccagta  540
aagggcctc  tgccgaatt  ttggcctcg  gggccaaa  578



<210> 7084
<211> 278
<212> PRT
<213> Rattus norvegicus
<308> O35796
<400> 7084

Met Leu Pro Leu Leu Arg Cys Val Pro Arg Ala Leu Gly Ala Ala Ala 
  1               5                  10                  15
Thr Gly Leu Arg Ala Ser Ile Pro Ala Pro Pro Leu Arg His Leu Leu 
             20                  25                  30
Gln Pro Ala Pro Arg Pro Cys Leu Arg Pro Phe Gly Leu Leu Ser Val 
         35                  40                  45
Arg Ala Gly Ser Ala Arg Arg Ser Gly Leu Leu Gln Pro Pro Gly Ser 
     50                  55                  60
Cys Ala Cys Ala Ala Ala Leu His Thr Glu Gly Asp Lys Ala Phe Val 
 65                  70                  75                  80
Glu Phe Leu Thr Asp Glu Ile Lys Glu Glu Lys Lys Ile Gln Lys His 
                 85                  90                  95
Lys Ser Leu Pro Lys Met Ser Gly Asp Gly Glu Leu Glu Val Asn Gly 
             100                105                110
Thr Glu Ala Lys Leu Leu Arg Lys Val Ala Gly Glu Lys Ile Thr Val 
         115                120                125
Thr Phe Asn Ile Asn Asn Ser Ile Pro Pro Thr Phe Asp Gly Glu Glu 
     130                135                140
Glu Pro Ser Gln Gly Gln Lys Ala Glu Glu Gln Glu Pro Glu Leu Thr 
 145                150                155                160
Ser Thr Pro Asn Phe Val Val Glu Val Thr Lys Thr Asp Gly Lys Lys 
                 165                170                175
Thr Leu Val Leu Asp Cys His Tyr Pro Glu Asp Glu Ile Gly His Gln 
             180                185                190
Asp Glu Ala Glu Ser Asp Ile Phe Ser Ile Lys Glu Val Ser Phe Gln 
         195                200                205
Thr Thr Gly Asp Ser Glu Trp Arg Asp Thr Asn Tyr Thr Leu Asn Thr 
     210                215                220
Asp Ser Leu Asp Trp Ala Leu Tyr Asp His Leu Met Asp Phe Leu Ala 
 225                230                235                240
Asp Arg Gly Val Asp Asn Thr Phe Ala Asp Glu Leu Val Glu Leu Ser 
                 245                250                255
Thr Ala Leu Glu His Gln Glu Tyr Ile Thr Phe Leu Glu Asp Leu Lys 
             260                265                270
Ser Phe Val Lys Ser Gln 
         275



<210> 7085
<211> 1163
<212> DNA
<213> Homo sapiens
<308> XM_012676
<400> 7085

ccggcggcg  ctcaggtcg  ggggcgcct  ggcctgggt  gtcctttgc  tctgcacgt  60
ttcgcagtc  tttccgcga  gctgcctct  ctgcgctgc  tgccccgtg  gctgggctc  120
tccgtcgcc  gcctccgcg  tgccgcgcc  gcctcgcct  tccggcagc  cctgcagcc  180
gcaccccgg  tgtgcaccc  gcccttcgg  ctgctcagc  tgcgcgcag  ttccgagcg  240
cggccgggc  tcctgcggc  tcgcggacc  tgcgcctgt  gctgtggct  cggctcgct  300
cacaccgac  gagacaaag  ttttgttga  ttcctgagt  atgaaatta  ggaggaaag  360
aaaattcag  agcataaaa  cctccctaa  atgtctgga  gttgggagc  ggaactgaa  420
gggacagaa  cgaaattag  gcggaaagt  gccggggaa  aaatcacgg  cactttcaa  480
attaacaac  gcatcccac  aacatttga  ggtgaggag  aaccctcgc  agggcagaa  540
gttgaagaa  aggagcctg  actgacatc  actcccaat  tcgtggttg  agttataaa  600
aatgatgat  gcaagaagg  ccttgtgtt  gactgtcat  atccagagg  tgaggttgg  660
caagaagac  aggctgaga  tgacatctt  tctatcagg  aagttagct  tcagtccac  720
ggcgagtct  aatggaagg  tactaatta  acactcaac  cagattcct  ggactgggc  780
ttatatgac  acctaatgg  tttccttgc  gaccgaggg  tggacaaca  ttttgcaga  840
gagctggtg  agctcagca  agccctgga  caccaggag  acattactt  tcttgaaga  900
ctcaagagt  ttgtcaaga  ccagtagag  agacagatg  tgaaagcca  agtttcatg  960
caggctttg  ccagtgaac  aatcctact  tgaagctag  catgtgctt  gaaatgatt  1020
tcatcctaa  atcatgggg  aaaaaatac  aaatttaaa  tatatgttt  gtgttctca  1080
ttattatca  ttttttctg  acaaatcta  tatttctag  tttttgtat  acatgatag  1140
cataaaatt  gtttatctc  tcc  1163



<210> 7086
<211> 282
<212> PRT
<213> Homo sapiens
<308> XP_012676
<400> 7086

Met Leu Pro Leu Leu Arg Cys Val Pro Arg Val Leu Gly Ser Ser Val 
  1               5                  10                  15
Ala Gly Leu Arg Ala Ala Ala Pro Ala Ser Pro Phe Arg Gln Leu Leu 
             20                  25                  30
Gln Pro Ala Pro Arg Leu Cys Thr Arg Pro Phe Gly Leu Leu Ser Val 
         35                  40                  45
Arg Ala Gly Ser Glu Arg Arg Pro Gly Leu Leu Arg Pro Arg Gly Pro 
     50                  55                  60
Cys Ala Cys Gly Cys Gly Cys Gly Ser Leu His Thr Asp Gly Asp Lys 
 65                  70                  75                  80
Ala Phe Val Asp Phe Leu Ser Asp Glu Ile Lys Glu Glu Arg Lys Ile 
                 85                  90                  95
Gln Lys His Lys Thr Leu Pro Lys Met Ser Gly Gly Trp Glu Leu Glu 
             100                105                110
Leu Asn Gly Thr Glu Ala Lys Leu Val Arg Lys Val Ala Gly Glu Lys 
         115                120                125
Ile Thr Val Thr Phe Asn Ile Asn Asn Ser Ile Pro Pro Thr Phe Asp 
     130                135                140
Gly Glu Glu Glu Pro Ser Gln Gly Gln Lys Val Glu Glu Gln Glu Pro 
 145                150                155                160
Glu Leu Thr Ser Thr Pro Asn Phe Val Val Glu Val Ile Lys Asn Asp 
                 165                170                175
Asp Gly Lys Lys Ala Leu Val Leu Asp Cys His Tyr Pro Glu Asp Glu 
             180                185                190
Val Gly Gln Glu Asp Glu Ala Glu Ser Asp Ile Phe Ser Ile Arg Glu 
         195                200                205
Val Ser Phe Gln Ser Thr Gly Glu Ser Glu Trp Lys Asp Thr Asn Tyr 
     210                215                220
Thr Leu Asn Thr Asp Ser Leu Asp Trp Ala Leu Tyr Asp His Leu Met 
 225                230                235                240
Asp Phe Leu Ala Asp Arg Gly Val Asp Asn Thr Phe Ala Asp Glu Leu 
                 245                250                255
Val Glu Leu Ser Thr Ala Leu Glu His Gln Glu Tyr Ile Thr Phe Leu 
             260                265                270
Glu Asp Leu Lys Ser Phe Val Lys Ser Gln 
         275                280



<210> 7087
<211> 520
<212> DNA
<213> Rattus norvegicus
<308> AI178204
<400> 7087

atttaaatg  tctgctgtt  tagattctt  tagtattat  agaatgaaa  gttttatga  60
acaatcact  gtctgcaca  gataaacac  gggttaagc  cacttaatc  ttctgctga  120
atctgaatg  ccatctcga  tgaccatac  catgtccag  aggcaaaat  actcttctt  180
cagtgcata  accaataca  ccaaggtat  gattcattt  agaaatttg  tagcatatg  240
attttcatt  tgagtacaa  cttgtatca  aaaataaac  tatttccaa  ctgagatat  300
tattttgca  agctatact  taggcacat  gaccattcc  aaaaaaaaa  aaagaagtg  360
tttttcaca  gtatttcct  agaacccac  ttgtgccag  agctataat  aaacatagg  420
cttacagcc  caggcatgg  ggttgggtg  gtaagtatg  aggcacaac  ttgcctcgt  480
ccgaattct  ggcctcgag  gccaaattc  ctatagtgag  520



<210> 7088
<211> 619
<212> DNA
<213> Rattus norvegicus
<308> AI178208
<400> 7088

aggacagat  acagtttta  ttttaatga  ataagcaag  acaatctca  attcatact  60
aaaatctca  ctacactaa  agaaacgca  tctgtggtg  aagccccag  ctccctgtc  120
ctgtccagc  tgagcacgg  cagatgtgc  cacacaccg  ggctattcc  ggacacctc  180
tccggcacc  tggatacag  cctgctgtg  agctgaggt  attagctca  actgaattg  240
agggaggcc  ttccttacc  gaggcacag  tagaggctt  gtgttcaga  ccccaccca  300
ccccatcct  acaggcatt  gggacttga  gtccagctc  tcttcagtt  catacaacc  360
agcctaacc  ctgccataa  acattcaat  ccactcaca  ggaaagggg  ccagttaca  420
ctacatcac  ctgtttata  aataagagt  acacttaca  gacatgtct  gaaggagct  480
tgccccctc  ggagagctg  tggggacag  tatgagccc  tcctttaca  aagcataac  540
atacagcta  ttcctacta  tccatagca  ttatactta  ccaccttag  gaacccaag  600
ttgaaggaa  ttaaaaggc  619



<210> 7089
<211> 1199
<212> PRT
<213> Rattus norvegicus
<308> P52591
<400> 7089

Met Ser Pro Ala Ala Ala Ala Ala Asp Gly Gly Glu Arg Arg Arg Pro 
  1               5                  10                  15
Pro Leu Gly Val Arg Glu Gly Arg Gly Arg Thr Arg Gly Cys Gly Gly 
             20                  25                  30
Pro Ala Gly Ala Ala Ala Leu Gly Leu Ala Leu Leu Gly Leu Ala Leu 
         35                  40                  45
Tyr Leu Val Pro Ala Ala Ala Ala Leu Ala Trp Leu Ala Val Gly Ala 
     50                  55                  60
Ser Ala Ala Trp Trp Gly Leu Ser Arg Glu Pro Arg Gly Pro Arg Gly 
 65                  70                  75                  80
Leu Ser Ser Phe Val Arg Glu Ser Arg Arg His Pro Arg Pro Ala Leu 
                 85                  90                  95
Thr Ala Ser Pro Leu Pro Ala Lys Ser Pro Val Asn Gly Ser Leu Cys 
             100                105                110
Glu Pro Arg Ser Pro Leu Gly Gly Pro Asp Pro Ala Glu Leu Leu Leu 
         115                120                125
Met Gly Ser Tyr Leu Gly Lys Pro Gly Pro Pro Glu Pro Ala Leu Pro 
     130                135                140
Gln Asp Pro Arg Asp Arg Pro Gly Arg Arg Pro Pro Ser Arg Ser Pro 
 145                150                155                160
Pro Ser Ser Ser Thr Ala Gln Arg Val His His Val Tyr Pro Ala Leu 
                 165                170                175
Pro Thr Pro Leu Leu Arg Pro Ser Arg Arg Pro Pro His Arg Asp Cys 
             180                185                190
Gly Pro Leu Ser Ser Arg Phe Val Ile Thr Pro Arg Arg Arg Tyr Pro 
         195                200                205
Ile Gln Gln Ala Gln Tyr Ser Leu Leu Gly Ala Leu Pro Thr Val Cys 
     210                215                220
Trp Asn Gly Gly His Lys Lys Ala Val Leu Ser Ala Arg Asn Ser Arg 
 225                230                235                240
Met Val Cys Ser Pro Val Thr Val Arg Ile Ala Pro Pro Asp Ser Lys 
                 245                250                255
Leu Phe Arg Ser Pro Met Pro Glu Gln Ile Leu Ser Thr Thr Leu Ser 
             260                265                270
Ser Pro Ser Ser Asn Ala Pro Asp Pro Cys Ala Lys Glu Thr Val Leu 
         275                280                285
Asn Ala Leu Lys Glu Lys Lys Lys Arg Thr Val Ala Glu Glu Asp Gln 
     290                295                300
Leu His Leu Asp Gly Gln Glu Asn Lys Arg Arg Arg His Asp Ser Ser 
 305                310                315                320
Gly Ser Gly His Ser Ala Phe Glu Pro Leu Val Ala Asn Gly Val Pro 
                 325                330                335
Ala Ala Phe Val Pro Lys Pro Gly Ser Leu Lys Arg Ser Leu Ala Ser 
             340                345                350
Gln Ser Ser Asp Asp His Leu Asn Lys Arg Ser Arg Thr Ser Ser Val 
         355                360                365
Ser Ser Leu Thr Ser Thr Cys Thr Gly Gly Ile Pro Ser Ser Ser Arg 
     370                375                380
Asn Ala Ile Thr Ser Ser Tyr Ser Ser Thr Arg Gly Val Ser Gln Leu 
 385                390                395                400
Trp Lys Arg Ser Gly Pro Thr Ser Ser Pro Phe Ser Ser Pro Ala Ser 
                 405                410                415
Ser Arg Ser Gln Thr Pro Glu Arg Pro Ala Lys Lys Thr Arg Glu Glu 
             420                425                430
Glu Pro Cys His Gln Ser Ser Ser Ser Ala Pro Leu Val Thr Asp Lys 
         435                440                445
Glu Ser Pro Gly Glu Lys Val Thr Asp Pro Ala Thr Gly Lys Gln Gln 
     450                455                460
Ser Leu Trp Thr Ser Pro Pro Thr Pro Gly Ser Ser Gly Gln Arg Lys 
 465                470                475                480
Arg Lys Ile Gln Leu Leu Pro Ser Arg Arg Gly Asp Gln Leu Thr Leu 
                 485                490                495
Pro Pro Pro Pro Glu Leu Gly Tyr Ser Ile Thr Ala Glu Asp Leu Asp 
             500                505                510
Met Glu Arg Arg Ala Ser Leu Gln Trp Phe Asn Lys Val Leu Glu Asp 
         515                520                525
Lys Thr Asp Asp Ala Ser Thr Pro Ala Thr Asp Thr Ser Pro Ala Thr 
     530                535                540
Ser Pro Pro Phe Thr Leu Thr Leu Pro Thr Val Gly Pro Ala Ala Ser 
 545                550                555                560
Pro Ala Ser Leu Pro Ala Pro Ser Ser Asn Pro Leu Leu Glu Ser Leu 
                 565                570                575
Lys Lys Met Gln Glu Ser Pro Ala Pro Ser Ser Ser Glu Pro Pro Glu 
             580                585                590
Ala Ala Thr Val Ala Ala Pro Ser Pro Pro Lys Thr Pro Ser Leu Leu 
         595                600                605
Ala Pro Leu Val Ser Pro Leu Thr Gly Pro Leu Ala Ser Thr Ser Ser 
     610                615                620
Asp Ser Lys Pro Thr Thr Thr Phe Leu Gly Leu Ala Ser Ala Ser Ser 
 625                630                635                640
Ala Thr Pro Leu Thr Asp Thr Lys Ala Pro Gly Val Ser Gln Ala Gln 
                 645                650                655
Leu Cys Val Ser Thr Pro Ala Ala Thr Ala Pro Ser Pro Thr Pro Ala 
             660                665                670
Ser Thr Leu Phe Gly Met Leu Ser Pro Pro Ala Ser Ser Ser Ser Leu 
         675                680                685
Ala Thr Pro Gly Pro Ala Cys Ala Ser Pro Met Phe Lys Pro Ile Phe 
     690                695                700
Pro Ala Thr Pro Lys Ser Glu Ser Asp Asn Pro Leu Pro Thr Ser Ser 
 705                710                715                720
Ser Ala Ala Thr Thr Thr Pro Ala Ser Thr Ala Leu Pro Thr Thr Ala 
                 725                730                735
Thr Ala Thr Ala His Thr Phe Lys Pro Ile Phe Glu Ser Val Glu Pro 
             740                745                750
Phe Ala Ala Met Pro Leu Ser Pro Pro Phe Ser Leu Lys Gln Thr Thr 
         755                760                765
Ala Pro Ala Thr Thr Ala Ala Thr Ser Ala Pro Leu Leu Thr Gly Leu 
     770                775                780
Gly Thr Ala Thr Ser Thr Val Ala Thr Gly Thr Thr Ala Ser Ala Ser 
 785                790                795                800
Lys Pro Val Phe Gly Phe Gly Val Thr Thr Ala Ala Ser Thr Ala Ser 
                 805                810                815
Thr Ile Ala Ser Thr Ser Gln Ser Ile Leu Phe Gly Gly Ala Pro Pro 
             820                825                830
Val Thr Ala Ser Ser Ser Ala Pro Ala Leu Ala Ser Ile Phe Gln Phe 
         835                840                845
Gly Lys Pro Leu Ala Pro Ala Ala Ser Val Ala Gly Thr Ser Phe Ser 
     850                855                860
Gln Ser Leu Ala Ser Ser Ala Gln Thr Ala Ala Ser Asn Ser Ser Gly 
 865                870                875                880
Gly Phe Ser Gly Phe Gly Gly Thr Leu Thr Thr Ser Thr Ser Ala Pro 
                 885                890                895
Ala Thr Thr Ser Gln Pro Thr Leu Thr Phe Ser Asn Thr Val Thr Pro 
             900                905                910
Thr Phe Asn Ile Pro Phe Ser Ala Ser Ala Lys Pro Ala Leu Pro Thr 
         915                920                925
Tyr Pro Gly Ala Asn Ser Gln Pro Thr Phe Gly Ala Thr Asp Gly Ala 
     930                935                940
Thr Lys Pro Ala Leu Ala Pro Ser Phe Gly Ser Ser Phe Thr Phe Gly 
 945                950                955                960
Asn Ser Val Ala Ser Ala Pro Ser Ala Ala Pro Ala Pro Ala Ala Phe 
                 965                970                975
Gly Gly Ala Ala Gln Pro Ala Phe Gly Gly Leu Lys Ala Ser Ala Ser 
             980                985                990
Thr Phe Gly Thr Pro Ala Ser Thr Gln Pro Ala Phe Gly Ser Thr Thr 
         995                1000                1005
Ser Val Phe Ser Phe Gly Ser Ala Thr Thr Ser Gly Phe Gly Ala Ala 
     1010                1015                1020
Ala Ala Thr Thr Gln Thr Thr His Ser Gly Ser Ser Ser Ser Leu Phe 
 1025                1030                1035                1040
Gly Ser Ser Thr Pro Ser Pro Phe Thr Phe Gly Gly Ser Ala Ala Pro 
                 1045                1050                1055
Ala Gly Gly Gly Gly Phe Gly Leu Ser Ala Thr Pro Gly Thr Gly Ser 
             1060                1065                1070
Thr Ser Gly Thr Phe Ser Phe Gly Ser Gly Gln Ser Gly Thr Thr Gly 
         1075                1080                1085
Thr Thr Thr Ser Phe Gly Gly Ser Leu Ser Gln Asn Thr Leu Gly Ala 
     1090                1095                1100
Pro Ser Gln Ser Ser Pro Phe Ala Phe Ser Val Gly Ser Thr Pro Glu 
 1105                1110                1115                1120
Ser Lys Pro Val Phe Gly Gly Thr Ser Thr Pro Thr Phe Gly Gln Ser 
                 1125                1130                1135
Ala Pro Ala Pro Gly Val Gly Thr Thr Gly Ser Ser Leu Ser Phe Gly 
             1140                1145                1150
Ala Pro Ser Thr Pro Ala Gln Gly Phe Val Gly Val Gly Pro Phe Gly 
         1155                1160                1165
Ser Gly Ala Pro Ser Phe Ser Ile Gly Ala Gly Ser Lys Thr Pro Gly 
     1170                1175                1180
Ala Arg Gln Arg Leu Gln Ala Arg Arg Gln His Thr Arg Lys Lys 
 1185                1190                1195



<210> 7090
<211> 31737
<212> DNA
<213> Homo sapiens
<308> AC006014
<400> 7090

gatcacttg  agcctattt  taattttta  tttttaaag  aaaacaaca  aagagaagg  60
tgatcccaa  ctacagggt  tttttgttt  tttgtttgt  tgtttgttt  ggagacagt  120
tcgctctgt  tcccaggct  gagtgcagt  gcacaacct  ggctccctg  aactttcac  180
tcggcgttc  agcaaattc  cctgcctca  cctcccaag  agctgggac  acaggcatc  240
gcctgtacg  ctgactaac  tttgtaaaa  tagtagaga  aaggtttca  catgttggc  300
aggctggtc  caaactcct  acctcaagt  atccacccg  ctcagtctc  caaagtgct  360
ggattatag  catgagcta  tgtgcccag  ccccaagct  gagttttaa  gcaggaaat  420
agagaaaga  attgagaga  gaaaaccag  tggtaagaa  actctaaag  tggctgggc  480
tggtggctc  cgcctgtga  cccagcagg  gttcgagac  aggcaggag  atcactagc  540
gagaatatg  ctccccaac  cctctcaaa  aaaaaaaaa  aaaagtcca  gcgcggtgg  600
tcaggactg  aatcccagc  ctttgggag  ctgaggtgg  tggatcatg  ggtcaggag  660
tcaagacca  cctggctaa  acggtgaaa  cccatctct  ctaaaaata  aaaaaatta  720
ctgggtgcg  tggcaggcg  ctgtagtcc  agctactcc  gaggctgag  caggagaat  780
gtgtgaacc  aggaggcgg  gcctgcagt  agcagagat  gcgccactg  actccagcc  840
gggtgaaag  gcgagactc  atcacaaaa  aaaaaaaaa  aaagaaagt  cctgcaaca  900
ttcaagctg  gaaagacag  cactctgcc  tgcaattct  tgtgatttt  cttttttat  960
tttggagtc  gggtcttgt  ctgtcaccc  gactggggt  cagtggtgc  gtcatagct  1020
actgtgggc  cagactcaa  ctcaagcaa  cttcttatc  tgcctttct  attgctggg  1080
ttataagca  gagccactg  acctggcct  tgtgacgta  ttctgatgt  aactccctg  1140
tgttacatc  aatgccaca  gttaaggcc  ccagccccc  ctaggctgc  ctcgcttca  1200
atgcagctg  aagcttggg  gtccacaga  cgcatgtac  tctcaccaa  tggctgcaa  1260
tttggaggt  cccaccacg  cctcaggtt  gataattca  cataacaac  cacagaact  1320
tgaaaagca  gatactttc  ctttcttta  ttgagacag  gtcttgctc  gtcacccag  1380
ctggagtgc  gtggccacc  tgcttggct  attttagta  ttgtattag  gacagggtt  1440
cgccatgtt  gccaggctg  tcttgaact  ctgacctca  gtgatccac  caccttggc  1500
tcccaaagt  ctgggatta  aggcatagc  actgtgcct  gctgacttc  agagtttca  1560
taacagaga  gtggttcaa  aagaaaagg  agacatgtt  tgtagacag  aggagcttc  1620
tgaaaagaa  ccaatgaag  gcaggatgt  tagctgtct  cctacagga  accagccag  1680
agcctcccc  cagggactt  agcacagat  gccgggaaa  tctgcattc  cctgagctc  1740
ggacctaag  gaggacaag  ccttgactg  ttctacaga  tcacaagat  caatctctg  1800
ggtccatgc  cgtggtgtg  tctgggaaa  agggggcct  ctaaatgcc  acaacaagg  1860
aatcaaatg  gcaacagac  gaaatatcg  cattgacac  ggccatgga  aggcctaaa  1920
agatgactg  agtccactg  caaggtcat  aaaggggtg  ctctgaaat  agaaatttc  1980
gacgccacg  cccaaatag  tgcacgagg  ggggaagtc  tccacatgc  tctgcttcc  2040
tcagtacct  ttcatgaaa  aagccgagg  acttccctg  ggaatttcc  ttctctttc  2100
ttctttcga  acggagtct  gctctgtcg  ccaggctag  gtgcagtgg  gcgatctcg  2160
ctcactgca  cctctccct  ccgggtttt  gcaattctt  tgtctcaga  ttctgagta  2220
ctgagatta  aggtgtgtg  caccatgcc  agctaatat  tgtattttc  ctcgagaca  2280
ggtttcacc  tctaggcca  gctggtctt  aactcctga  ctcatgatc  acccatctt  2340
gcctcccaa  gtcctggga  tacaggcac  agccaccac  cccagactt  ttgttttat  2400
ttttgagat  aagtttcgc  cttgttgcc  aggctggag  gcaatggcg  gatctcagc  2460
cactgccac  tcctcctcc  cccaggttc  agtgattat  ctgcctcag  ctcccgagt  2520
gctgggatt  caggcaccc  acaccaaac  ccgctgact  tttgtattt  tagtagaga  2580
ggaatgtca  catgttggc  aggatggtc  tgaacccct  acctctaat  atctacccg  2640
attggtctc  caaaatgct  ggattacag  cgtgagcca  tgtgcccag  ccctcccat  2700
cctcttttg  ccaaggcag  acaattcag  gaatcttgc  agggaagac  ggtaaatgg  2760
catcaacat  atgcctatg  ctcctggtg  atttagata  ctcctggtg  ttactgata  2820
ctttaccag  tacatgggg  cttttccat  ccagactga  aatgctgga  atcactgat  2880
aaccttcaa  tatttacta  cagaacact  aggggactc  gcagtcacc  atatctcct  2940
ttgcacttg  ataaacacc  cccgggaaa  agagatgaa  agaaaggaa  tacttaaac  3000
agcagaatg  ctacattcc  tcaaccaga  gggtccatt  gtctgtttt  acactgcta  3060
aaagaacta  tggaaactg  ggaatttat  aagaaaaga  gtttaattg  ctcacagtt  3120
tgcaggctg  acaggaagc  tggctgggg  gccctcaag  aactgacaa  cacggcaga  3180
ggcgaaggg  aagcaggca  gtttctggc  atggtggag  aggagagac  gagagagtg  3240
agcaggagg  gctgcatgc  tctaaacaa  cagatccca  gagcgctca  tcactatca  3300
gagaccagc  agggggacg  cagccgcca  gagccaatc  tctcccacc  ggtccctcc  3360
tcaacactg  gaattgcaa  tggacatga  atttggttg  ggatacaga  ctgaaccat  3420
tcaagggta  ttcaaccac  gagattgat  gattgactg  gatggggtc  tgctctgtt  3480
cctaggctg  agtgcagtg  cacaatctc  gctcactgc  acctccgcc  cccaggttc  3540
agcaattct  ctgcctcag  ctccctagt  gctgggact  cagcacacg  caccacacc  3600
ggctaattt  tgtattttc  gtagagacg  ggtttcacc  tgtttgccc  gctggtctt  3660
aactcctga  ctcgtgatc  ccctgcctc  gctcttctt  tgctggaat  acaggcgtg  3720
gccaccgca  ccggacaac  actgagatt  agaaggcag  cgagtccac  ataccacac  3780
tcacctggt  tcttcctct  ttggggccc  tcgtggcca  tgttctgtt  ctttttggt  3840
ctatttatt  aaatggatg  tgagctgtt  gtcctccag  atccaacac  tccaccttc  3900
gcttgtatt  caacaatac  agcctttca  gctactccg  gtgacccca  aactcatct  3960
aactcagaa  cccaagagt  tcattcctc  cactttagg  gactaagtg  ccctggtca  4020
catgaagtc  atacagaag  atgacctcc  tccctaatc  ctcaagaat  aggagtgga  4080
ggtgttggc  ggagggtgg  acgcggttt  taaatctgt  actgcatca  accaaatct  4140
gttcaactt  ttttttttt  gatggagtt  cactcttgt  acccaggct  gagtgcaat  4200
gcacgatct  agctcactg  aacctccac  tcctaggtt  aagcattct  ctgcctcag  4260
ctctggggt  gctgggatt  caagggtgc  ccaccacgc  tggctaata  ttatatttt  4320
agtagagac  gggtttcac  attttggcc  ggctggtct  gaactcctc  acctcaggt  4380
atccacctg  cttggcctc  caaagtgct  ggattacag  cgtgagtca  cgcacccga  4440
tcagttcaa  ttttatgta  tgaagttgt  agttgtttt  caattgcca  cgacctgca  4500
gttgaaggt  atgtaccct  tgcatgccc  ggttaacca  gcgtgccac  gtggagtgg  4560
acctaagag  tcagcctga  gagctcgga  cgatttaag  accagacac  cccaggcag  4620
agccaggat  caatcagat  gagttttgg  gtcacccca  ggcaggatc  agtcagatc  4680
cacctccca  cattacttt  ttgcaagat  caatcaaat  acacctcat  accctatgc  4740
tataaaacc  gacacagcc  ccagctgtg  aagggagat  tgagtactt  ctcctgtgt  4800
cttgctggc  gacttacaa  aaagcttta  aaaaaaaag  caggcgtgg  ggctcacgc  4860
tgtaatccc  gcactttgg  aggctgagg  gggcagatc  cttgaggtc  ggggtgcaa  4920
accagcctg  ccaacatgg  gaaacccca  ctctactaa  aatacaaaa  ttagctggg  4980
gtggtgaca  acacctata  tcccagcta  ttgggaggc  gaggtagga  aatcacttg  5040
acccaggag  cggaggttg  agtgagcca  gatcacacc  ctgcactcc  gcctgggcg  5100
cagagtgag  agactccgt  taaaaaaaa  agttaaaat  agcaccaaa  gctttacaa  5160
taaaaaaag  ttttagctg  atatgttta  gtaactttt  agattataa  aaatacgca  5220
gcaaaatgg  aaggcacaa  gaagagagc  aaaagtgca  gagatctca  atccaagga  5280
aaccgctga  aacatggaa  tgctgactc  tcagtcttt  tactataca  atttaggcc  5340
gttttgttt  tataaaact  taatcatat  atacagaca  ttttataat  tgcttttta  5400
acacaacaa  tatgtaaca  ttagctgtt  catttgcat  caaattcat  agggttcca  5460
taactcatt  atcagaaaa  caagagaaa  attctcata  aaatataag  acataaggt  5520
aggcatggt  gctcacgcc  gtaatccca  cactttgag  ggccgaggt  ggcggatca  5580
ctgagggca  gaattcaag  ccagcctgg  cagcctgga  aacatggtg  aaccccgtc  5640
ccactgaaa  tacaaaaat  agccgggcg  ggtggcgcg  gcctgtaat  gtagctact  5700
agaaggctg  agcaggaga  tcgcttgaa  ttggcaggt  gaggttgca  tgaactgag  5760
tcgcgccac  gcactgcag  cagggcgcc  aagtgagac  ccatctcaa  aaaagataa  5820
aataaaaaa  aaaaaaaat  tatatatat  tatatatat  tttccagac  gggtcttac  5880
ctgtctcac  gtctgaagt  tagtgacgc  atcatagct  actgcagtc  caagttcct  5940
ggctcaggt  atcctccca  ttcagcctc  caagtagct  gaactacag  tgcatgcca  6000
catgcccag  caatttttt  ttaattttt  atagagaca  agtctcact  tgtttccca  6060
tcctaataa  cattatgtg  taaaaagaa  aaagtaaat  atcctgaag  taagtcttt  6120
atgagaaat  caaataaag  atttctcaa  aaattatgg  aagagaatc  actgaagaa  6180
aaacatctt  agtaaatct  ttgctcatg  gcattaacc  atactcttg  aaaccagga  6240
taatttact  taccttctt  atattcctt  gaaattcct  atggcgcac  ggtagcgta  6300
aaaataact  cttcacgct  actgtggtc  ctctggggt  ggggtaggg  gttttctgg  6360
tgattttcc  atcgtgatc  aacaccagt  gagtcccaa  cttcgccga  acgtggcag  6420
tagaaatgg  gacatcact  tgagagaat  ccaggcatg  tgtgttcag  gagagatcc  6480
tgatgttgg  cactgacta  tcttttctt  acttgcttt  ctctcaaaa  tttcttaaa  6540
agctgatga  ccctctgag  taaccgaga  ctaaacggt  gaggagtca  cacaaaatc  6600
aaggtctgg  atctaaaag  cagtgagac  gagagcact  aacatgctt  gttttgata  6660
aagctttga  ttcattttt  aggttgaat  gcaaaacca  aaatgatct  aagatttat  6720
gattctcaa  tagagattt  ttttgttat  actcttcaa  caaaatttt  taaaagaat  6780
tttttaaag  attttttaa  atttttaaa  tttttttta  agaatccaa  agatattat  6840
attaaaatg  atatgtagg  cagggtgcg  tggctcgtg  ctgtaattc  agcactttg  6900
gaggccaag  agggcagat  acttgaggc  tggagttcc  gaccagcct  ggcaacatg  6960
caaaacccc  tctctacta  aaatacaaa  attagccag  agtggtggt  cacgctata  7020
tcccagctc  tcaggaggc  gagtcacga  agtcacttg  acctgggag  cagagactg  7080
agtgagctg  gactgtgcc  ctgcactcc  gcctgggtg  cagagtgcg  ctctgtcta  7140
aaaaaaaaa  aatatatat  tatacatat  tatgtatat  tatatgtat  tatatatgt  7200
tatatatgt  tatatgtat  tatatgtat  tatgtatat  tgtatatat  tatgtatat  7260
tgtatatat  tatatatgt  tatatgtat  tatatgtat  tatgtatat  tatgtatat  7320
tatatgtat  tatatgtat  tatatgtat  tatatgtct  tatatgtgt  tgtgcatgt  7380
attatttat  aaaatttag  atctgtgct  taattaaat  gtgctttgg  gaaatgttt  7440
cctaaaaat  gataatgaa  accaatggt  actatcatt  attatctat  tgttatgtt  7500
aaattgaga  gttactgtt  taataaggg  aaccaattt  ttaaagaat  ctatttgct  7560
catttcatt  atttattgc  cacatttca  aagtactag  acttagatt  gcagtgaga  7620
aaaacagaa  tcagaagct  gaagctgag  tattgagat  gaaaattgt  aataataat  7680
attccaatt  attttcaga  aggtttttc  aaggggtca  gtgaatgga  aaaaatatt  7740
tctcacctc  gtgcacaaa  tgagctcag  gctttcccc  gaaagccaa  agtttcaac  7800
cgagttagg  cggcaaact  tcgaatctt  gatgtgtga  gtttcagag  tgaaagaga  7860
tgtaaagta  ggactaaga  atctcaagt  ctataacaa  aaatataca  gatatctag  7920
aactggctt  aaaaaactg  ttttgtgtt  cccaagaca  tgttactca  aattctaag  7980
catgtggcc  aattatttt  taataggat  agaaagtta  cttacttaa  ccttcgaag  8040
tttcttctt  taccccaca  ccattgcct  aaacttcaa  gagatccat  ccatagtcc  8100
taagcttta  atctagaaa  tttaaaata  ttatatatt  attaaaaat  gacccacgc  8160
atcagtttt  atattgata  tatttataa  gtgcaaatt  aagtgtcgt  actatacct  8220
tagttaaac  tactagtgt  attttgtat  tttcatttt  ataaagttc  ttctggcca  8280
ttactagcc  agattaaat  gtttagcat  ttctttctt  cctcttttt  ttttcctta  8340
actagtcaa  tgaagcagt  ggagtggag  aggaacaaa  aaatctgta  ctggttgtg  8400
tcaattagt  gtaaagacc  ttgcacttt  accagcctt  tcctttgaa  gaaataatt  8460
taacatacc  agtaaggag  acgggggcc  ggcgcagtg  ttcatgcct  taatcccag  8520
actttggga  accaaagcg  gcggatcac  tgaggtcag  agttcgaga  cagcctgac  8580
aacgtagag  aactctatc  ctactaaaa  tacaaaatt  gccaggcgt  gtggtgcat  8640
cctgtaatc  cagctactt  tgaggctga  gcaggagaa  cgcttgaac  tgggaggtg  8700
aggttgcag  gagttgaga  cgtgccatt  caccgcagc  tcggcaaca  gagcaaaac  8760
ctatctcaa  aaaaaaaaa  agaaaaaaa  acagaactg  ttctggaat  agacttcct  8820
gattctatt  tattagctt  ataatctca  aaaaaggaa  tttactgtc  cttaatttc  8880
tcaactgta  aatggaggt  ataagttct  tctcataaa  ttatttggc  gattaataa  8940
tttttttta  ttttgtcat  ttctttttt  tctttcctt  ttttttttt  ttttaattt  9000
ttgagatgg  cttttgctc  tgtcaccca  gctggaatg  agtggcaca  tcgatcttg  9060
ctcactgca  cctccacct  ccaggttta  gcaattctc  tccctcagc  ttctgagga  9120
ctgagagta  agccatgca  catcacatc  ggctaattt  tgtattttt  gtagagaca  9180
ggttttacc  cgttggtta  gctggtctt  aactcctga  ctcaaagca  cagcccccc  9240
cagcctccc  aagtgctgg  attacagat  tgagccact  ctccaggat  tattttatt  9300
tattttatt  tattttttt  agacagagt  ttgctctgt  cccaggctg  cgtgcagtg  9360
cacaatctc  gttcactgc  acctccacc  cccaaattt  aacaattct  attcctgag  9420
ctccccagt  gctgggatt  caggcttct  ccaccaggt  tggctaatt  ttgtatttt  9480
agtagagac  gagtttcac  attttggac  ggctggtct  gaattcctg  cctcaggta  9540
ccacccgcc  tggcctccc  aagtgctgg  attacaggc  tgagccacc  cacccggcc  9600
gctttattt  ttaatagag  cgaggtctc  ccatgttgg  caggttggt  ttgaactct  9660
ggcttcaag  aatcccccc  cctcagcct  tcaaagggc  aggattaca  gcgtcagac  9720
ccacgccca  ctattctgc  aattaaatg  gatatttct  tgcaattct  agcataaca  9780
ctgcctggc  caccataag  acacaagaa  agctgtcgt  attattatt  ctacctagc  9840
aagtactag  cacataata  gtgctaact  taacttaaa  ataatagtt  attactaca  9900
caacacttg  tagtcttat  tcaataaca  atgtttctt  actacaaca  cattcactg  9960
tcatttctt  tggcttaaa  ctctcccaa  cttaccaat  ttagtggca  cagcatcca  10020
actgtttcc  actatcttc  tcaccgcag  gcttagact  agtaccacc  gcccagagc  10080
aatctgatg  actgacttc  gatcaatag  tttgatggc  ttagcaggt  ctgtactaa  10140
gaaatcagt  acaagaaac  aagcaggta  tcagctata  attttcatc  tgattttaa  10200
tgtgggaaa  gactcaaca  tgcaaatag  ttatgggtc  aatctattc  tttattata  10260
taacaaata  atttattat  tccagaaat  gaaacattg  tttacaatc  ttaaacaag  10320
acccaaaat  cttctggat  gacacttca  attcaacac  tccttacta  ctagtatcc  10380
catggagaa  acatacatt  tatctctca  attaccaaa  tctttggca  taatggtgt  10440
ttctttctt  aaaactgaa  gcatggccg  tgcggtggc  catgcctgt  atcccagca  10500
tttgggaca  agaggcagg  ggatcactt  agatcagga  tttgagacc  gcctggcca  10560
cgtcgtgaa  ccctgtctc  accaaaaat  caaaaaatt  gccaggcat  gtggtgggc  10620
cctgtaatc  cagctactt  ggaggctga  gcagaagaa  cacttaaac  tgggaggcg  10680
aggttgcag  gagctgaga  tgcagcatt  caccctagg  tgggcaatg  gcaaaaaaa  10740
aagtaaaag  aacataatt  cccacataa  tagaaaaac  aacagtatg  tgggaaata  10800
acaatgttt  agtcaaaat  atctcagaa  ttggatacc  gttatataa  tattcctta  10860
acacagttg  ctttgatac  ctactccaa  ttgaagctg  cagctgctg  cttagcaaa  10920
accctcaaa  ttcttgctg  acttgtttt  agaggtttt  ttttttttt  ttttttttt  10980
gagacggat  cttgctctg  cgccctgtc  cccaggctg  agtgcagtg  cacgatctt  11040
gctcactgc  agctctgcc  cccgggttc  caccattct  ctgcctcag  ctcctgagt  11100
gctgggact  caggcgccc  ccaccatgc  cagctaatt  tttgtattt  tagtagaga  11160
agggttcca  cgttttagc  aggatggtc  cgatctcct  acttcgtga  ccgcccgcc  11220
cagcctccc  aagtgctgg  attacaggc  tgagccacc  tgcccagcc  actttaaga  11280
ttttataac  gtttcattt  cccttattc  ctgctccaa  ccatcctcc  ctctatcac  11340
agagctatt  ttgaaatca  gaatctggt  aaataattt  tctgcttga  aaattacta  11400
tgccccact  cctactata  gaaacttaa  atctagtca  cactgggcc  caaactacc  11460
tcttttcag  atctctctg  tcctttccc  tcatcaagt  ccctacatt  ttattatta  11520
tattattat  attattatt  ttgacagag  ctcaccctg  cacctgggc  agagtgcaa  11580
ggcatgatc  cggctcact  caacctcca  ctcccaagt  caagtgatt  tcctgtctc  11640
gcctcccaa  ttgctggga  tataggcat  caccattac  ctcagctaa  ttttgtgtt  11700
ttagtagag  tggggtttc  ccatgttgg  caggctggt  tctaactcc  gacctcagg  11760
gatctgccc  ccttggcct  ccaaagcac  aggattaca  gtgtgagcc  ccgcaactg  11820
ccgtcccct  tattgcagc  cagtgaaca  ctgtttcct  aacatcaca  gctctctta  11880
acactacag  gtataagca  gtctctgtc  aaactgctc  cctcttgcc  ctctgccca  11940
ccaatgtct  ctcatccaa  gaatgtatc  cgtgtgttc  ttaacttag  aagttccca  12000
taaacagtt  aattgatca  tcgttaaga  aaggcggga  acctccatg  aaagagaaa  12060
cagtgggta  ttcctacag  atttaacac  tcgtaggcc  tcaataaac  cttgtgaaa  12120
aaacaaacc  ctttactct  cattctatg  tgctaagaa  ctcacctaa  tctgtctac  12180
atgtgaaac  gcagatgac  tcacagaaa  tggaaagaa  tatctctaa  aataagttt  12240
tttggcaac  cactacagg  tacaggttc  cttctgatt  tttttcttt  ttttttttt  12300
agatggagt  ttgctgtgt  tacccaaga  atgttttag  ctgtaaatt  gaggctgaa  12360
aacatcata  catcacttt  gccctactc  atgactatc  tgttactaa  gttgggcca  12420
aattaaagg  ggggtcata  gcccccacc  cttttttta  tttcagaca  ggtctccct  12480
cgctgtcca  gctggagtg  aggggcgca  tcatagctc  ctgcagcct  gacctccca  12540
gctcaagca  tcctcctgc  tcagcctcc  aagtagctg  gacatgggc  tgcatcatc  12600
cagctggct  attaaaaac  tttttttgt  gagacggag  ctcgctctg  tgtccaggc  12660
ggagtggag  ggtgcgctc  cggctcact  caacctctg  ctcctgggt  caagcaatt  12720
tcctgcctc  gcctcctga  tacctggga  tacaggtgc  caacaccac  cctggctaa  12780
tttttgtat  ttagtagag  caggatttc  ccatgttgc  caggctggt  tcaaactcc  12840
cagctcagg  aacccgcct  ccttggcct  ccaaagtgc  aggattaca  gcatgagtg  12900
ccatgccca  cctaaaaac  tttttttaa  ggatgggat  ttgctaggc  gcccaggct  12960
gtcttgaag  cctggcctc  agcaatcct  ccaccttgg  ctcccaaag  tctaggatt  13020
caggcgtga  ccaccatgc  tggctgatc  tcacctatt  ttttgttgt  gtttgagac  13080
gggtctatc  ccatctcct  ggctggagt  cagtggctt  atcatggct  actccagcc  13140
caacctcct  ggctcaagc  atgctacca  ttcagcctc  cgagtggct  cgactacag  13200
tgtgcacca  cacaccctg  taatttgtg  attttttgt  gagatgagg  cttgctatg  13260
tgcccaggc  agtttcaaa  tcctggcct  agtcaatcc  cccaccttg  cctcccaaa  13320
tgctgggat  ataggtgtg  gccaccacc  ctggccagc  cccacctgt  gatcaaagg  13380
gcatcaaag  atttgcagc  tccagaagg  ggtcatttc  tgcctctga  tctcagttt  13440
cacatctat  aaataaagt  aatgatcct  cactccagg  ttgtcgtga  ggctaaatt  13500
agttgtatt  ggaaaaata  gtggggcac  gtaggtgtg  ttctcacac  cagagtcag  13560
gtgtttagc  gagggttag  agttgcctc  agggcatga  gggctcttc  tgaccctaa  13620
tgtgaggaa  gctttgggt  aaaagattg  acttttctg  gttcagctg  aaggtggag  13680
gctcagtga  gtggctcac  cctgtaatt  caatgcttt  ggaggccga  gtgggagga  13740
cacttgagc  caggagttt  agagcagct  aaacaacac  gtaagacct  gtttctaca  13800
acacacaca  acacacaca  acacacaca  tagccaggc  tggtggcat  cgcctgtag  13860
tccagctac  tgggaggct  aggtgggtg  attgcttga  gcaaggagt  tgagacaag  13920
ctggtcaac  cagtgacac  ccatcatcc  ccaaaatca  ttttctttg  tttaaggca  13980
agcctcact  tattgccca  gctggagtg  agtggtgtg  tctcacctc  ttgcaacct  14040
tgcctcccg  gttcaagcg  ttcttgtgt  tcagcctcc  gagtagcta  gattacagg  14100
gtgcaccac  atgcctggc  aatttttgt  tttttagcg  agatggggt  ttgccatgt  14160
ggtcaggct  gtcttcaac  cctggcctc  agtgatccg  ctgccttgg  ctcccaaag  14220
gctgggatt  caggtgtga  ccactgtgc  cagccacaa  aaatcattt  taaaaggtt  14280
aatttaacc  catttaagt  atacatgta  gtctcatcg  atatttgaa  ccagtttgt  14340
aggtaaagt  tattattat  tgcatttta  ttcttagcg  ttaattaaa  cctcataag  14400
acaaataaa  acaggactt  ctataacag  ttgccacct  ttttcttta  agatgacga  14460
cagcatctt  tttgcgtta  cacaagtca  ccacataac  aatatagat  agaaaagtg  14520
ccaggtgtg  tggctcatg  ctctaatcc  agtactttg  gaggccgag  cagacagat  14580
acttgaggt  aggagttcg  gaccagcct  ggcaatatg  tgaaacccc  tctctatca  14640
aaatacaaa  attagcccg  catggtggt  ggcgcctgt  atcccagct  cttgggagg  14700
tgaggcagg  gaattgctt  aacctggaa  gcgaagttt  cagtgagcc  agatcatgc  14760
actgcactc  agcctgggt  acagagcga  actctgtct  gaaaaaaga  aaaagaaaa  14820
aaaagaaaa  taaggcact  agagggtaa  tggcttcac  cggtactaa  taggggagt  14880
tggatttga  ccaagctgt  ggttcaaac  acatcaaca  ctgctatgc  tgactgcgt  14940
tccacgctg  tgggaaggt  gactgaatc  gccactacc  ccctggggt  catgtgctt  15000
ccaaaccat  gcattatgt  aaaggcggt  ctgtaggtt  ttagttttt  aatttttat  15060
tttttgaga  agagtctca  tctgtcacc  aggctggag  gtagtggca  gatcttggc  15120
gactgcaat  tctgccttc  gggttcaag  gattctctt  cctcagcct  ctgagtagc  15180
gggactaca  gcccacacc  ccacgcctg  ctaattttt  tatttttag  agagacagg  15240
tttcaccat  ttggacatc  tggtctcgg  ctcttgggc  cattatctg  ctgcctcgg  15300
ctcccgaag  gctgggatt  caggtgtga  ccacagtgc  tggcctcta  tgacctcat  15360
ttaacttga  cacctctgt  aagactctg  ttccaataa  gtcacctct  aggtctgga  15420
ggtcatggc  tcaatacat  aattagggg  ggggggcac  ccatgcagc  cataatact  15480
gcgtatctg  ttatgttaa  cttgctata  ccacagtct  gctgacttg  attatggtg  15540
catgggaag  gcccttaaa  atcatctta  ctggttggg  tcaatggct  acgcgtgta  15600
ttccagcac  ttgagaggc  aaggcaaga  gatcgcttg  gaccaagag  tcaagacca  15660
tctgggcaa  agagcaaga  gctatatct  ctacaggca  gcacctgta  tctcagcta  15720
ttgggaggc  gagagaaga  gattgcttg  gcccaggag  caacagaga  ctgattgta  15780
cactgcacc  cagccgagg  aacagagag  tgattgtac  actgcaccc  agccaaggc  15840
acagagacc  tgtctctaa  aaacaaaaa  aggccgggt  cagtgtctt  tgcctgtat  15900
cccagcact  tgagaggca  aggcgggtg  atcatttga  gtcaggtgt  caagaccag  15960
ctggcaaac  tgacgaaac  ctaaaatac  aaaattagc  gggagtggt  gtgggtgcc  16020
gtaatctca  ctactcggg  ggctgaggc  ggagaatcg  ttgaacctg  gaggcagag  16080
ttgcagtga  ccgagatgg  gccactgca  tgcagcctg  gtgacaaga  caaaactct  16140
tctcaaaat  ttaggaaaa  aaaagagag  gagcctctt  tccatctcc  cgccacaga  16200
ttgtcttca  taatttcat  ccctttttt  ctgaggatt  actgggttt  tgggtccca  16260
aggggaagt  ctcttcaag  tacagaaac  acgactccg  agagaaccg  agagaaccg  16320
agagatggc  gcatgacca  accacggac  ggtgtgtag  agctgctgg  ctgaaactt  16380
ggctgaact  ccgctgcag  ttgacttat  cccatcagc  ccaaagccg  tggaggggg  16440
catccacta  caaatgaag  gggggcacg  attggaggc  gtttcagaa  gtcccactg  16500
gccacggac  caaggcctg  ccacagccc  cccaagcga  gcccagatc  tatttcacc  16560
cgctcagaa  accttgcca  ctcatttca  tccacagtg  ctttgcttt  tttaggatc  16620
ctcttgcac  gtccaactc  gagaatttc  aatctgaat  gattccaat  atggagcta  16680
atcaggcct  acctcagtt  tttaattac  atcaatagg  ctgggtccc  gcatctgtg  16740
cttaatgtt  ctccatgtg  tcctcatgc  gaaaggctg  tatttgaaa  tcccttttt  16800
tggggagtg  agggttttt  tagagacag  cctcactct  atgcccagc  tggaatgca  16860
tggtggatc  cagctcact  cagcctcga  ctcctggcc  caagaaatc  tcccacctt  16920
gccaaccaa  gtgttggga  tgcaggagt  accactgtg  ccagccagg  aagcccttc  16980
gtttcactt  aatgatatt  ctgctgcag  cctacagcc  ttgttgtat  aaacggcat  17040
attgcagga  aagaaaagg  gagaggtga  tgttttgct  ttttctgaa  atatcagac  17100
aaacctggg  tgtctggca  ttttttttt  ttttttttt  tgagtcgga  tctcactct  17160
tcgcccagg  tggagtgta  tgtcgtgat  tcggctcac  ggaacctcc  ccttcccgg  17220
tcaagtgat  ctcctgcct  agccccaca  gtagctggg  ttacagaag  gcactccca  17280
gcccagctc  ttgtttctg  atttttaca  aaaaacaga  aggtttcac  atgttggcc  17340
ggctgatct  aacctcctc  cctctggtt  tctgtcggc  tcagcttcc  aaagtgctg  17400
gattacaag  gtgagctgc  gcacctggt  tgcccattt  ttgacaatg  atcaacatc  17460
tctaagatg  gcactgcct  agtgtagtg  gtctagaca  ggtggccgg  acagagagg  17520
atatgcata  caggcttaa  gacgggtta  atcagagct  ttcattcca  aaaagagca  17580
ttttaatga  gtcagaaca  ggatgttct  atatttgaa  gcctgttaa  taggagaga  17640
agtaaagtg  tttgttgta  gaggacaca  ccagctctg  cggtttaaa  cgtcatgaa  17700
gcaaatttg  actccagaa  agcagagct  cctaacaat  ggacttcca  agcaatggg  17760
tttccttcc  cattcagtt  gtgcctttc  catgagcga  agactccta  gagagccgc  17820
gcccgttag  aagccatgt  ggaactcat  cacaggttc  ttttgtttt  tttttttgt  17880
gtttttttt  gagatgtag  tttgctctt  ttgcccagg  tggagtgca  tggtgtgac  17940
ttggctcac  gcaacctcc  cctcccaag  ttaagccat  ctgctgtcc  cgcctcctg  18000
gtggctggg  ttacaggca  ccaccacca  gcctgacta  ttttttgta  ttttagaag  18060
gatggggtt  caccatgtt  gccaggctg  tcttaaact  ctgacctca  gcgatccac  18120
tgctatggc  tcccaaagc  ctgggatta  aggcgtgag  cactgtgcc  ggccggaac  18180
cacaggttc  ttggatggt  tctgaatgt  atgaaactc  tttatattt  attaaaaaa  18240
tttttttga  acaaggtct  gctgtgttg  ccagactgg  gtgcggtgt  acgatcaca  18300
ctcactgca  cccctaact  ctaggctca  gcaatcctc  tgccacctc  gtctctcaa  18360
ttgttggaa  acaggtgcc  gccacgaca  ctggctaat  ttgttttgt  ttgttttgt  18420
ttgttttag  gatgggctc  tgctatgtt  cctatactg  tcttgaact  ctggcctca  18480
gcagtcttc  tcccttggc  acccaaaga  atgggatta  aagcatgag  cactgtgca  18540
agctgagat  tttcgactt  gtctttttg  acacccagt  tcttataga  tatccataa  18600
atagattca  aaataaacc  tttccttca  tggtataaa  aaataaacc  ctgctataa  18660
tggtggaat  ttctgagtt  agagcaata  atatgatac  aaacttgat  tatagagtt  18720
cttagccaa  ctggagggg  tggctttag  tgatccgtg  actccctga  attggggac  18780
ccattggaa  tatgtgtga  ctcatgggc  gtttcctat  atttccagt  ctcaaaata  18840
ctcttggac  caaagatgc  ttagggcag  ggacgcgtg  acccccagt  cagaatctc  18900
gacagtgaa  gtcagtaga  actcggcag  aaacctctg  caaattgag  gctctgatg  18960
gactttttc  tcaagtcaa  gttcctggg  tctcttgta  atgataatc  cactcttgt  19020
aggtttcat  gtttctgct  accctactt  tctttccca  cctgatccc  ctcccacca  19080
actggactc  gaaacgggc  tgtacagag  agaggagac  ccaacatgc  tcaagcttt  19140
agtggagag  acacagcct  tgctgggac  gggaacaga  ggatgcgga  accctgaag  19200
tgcttttgg  cagtggtct  aggttggga  agtggcagg  gataccatt  acccaggat  19260
tccaggaca  gagatcagc  tggcagtta  atgtgtttt  tttcaaact  gttgccagg  19320
tggcatgag  gatgacatc  gagattccg  ccttcctga  tggagggac  ggactctgt  19380
ggcacctgg  agttcagtt  gacaacagt  acttctcag  gctgttctc  actcctgac  19440
tctcccagc  tcgagaatt  ataacacac  cttctggat  ccagcagtg  ccagaagaa  19500
accaaggac  gaacagaga  taggtttgg  gagatggga  agattttgg  aaagatcat  19560
atgagccat  aaccgcagc  ccaggaaga  cggagcccc  agcggagca  ctcagggta  19620
cccctccag  aggtggtgg  tgatgaagt  tcgggacca  caggtgagg  gactggagg  19680
agaagaggt  gcataggat  gactaagat  aaggaaggg  gccaggcgt  gtggctcac  19740
cctgtaacc  caacacttt  ggaggctga  gcgggcaga  cacctgagg  caggagttc  19800
agaccagcc  ggccaacat  gtgaaaccc  atctctact  aaagtacaa  aattagcca  19860
gcggtagtg  tgtgtgcct  taatcccag  tacttggga  gctaagaca  gagaatcac  19920
tgagcctgg  aggaagagg  tgcagtgag  cgagatcgt  ctactgcac  ccagtctgg  19980
tgacagagt  agatgctat  tcaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaagaa  20040
aaaaaaaag  agggtcaga  gtcaggaag  agaacctgg  gagggtgtg  gggaagaat  20100
gagaaattc  ggctgggtg  agtggctca  acttgtaat  ccagcactt  gggaagcca  20160
ggcaggcgg  tcacttgag  ccaggagtt  gagaccagc  tggccaaca  ggtgaaacc  20220
tgtctctat  aaaagtaca  aatggagct  ggcattatg  caggcacct  taatcccag  20280
tacctgaga  gctgaggca  gagaataac  ggaatccgg  agatgcatg  tgcagtgag  20340
tgagattgc  ccactacac  ccagcctgg  tgacaaagc  agattctgt  tcgaaacaa  20400
aaaaaaaaa  aaaaagagg  actcagaga  ccagggacc  gggaaggat  tgaggcagt  20460
ttctgagga  agagagagg  aagaatggg  aggggaagg  gtggcacat  gggttgagc  20520
gaggagaaa  tcagaaagg  ggcttggag  agccagcag  ctgcgaggc  ggggaggat  20580
gagagtggt  tggggtttg  ggtcggggt  taacgtgat  agttgcaga  gcattacac  20640
gtggcctgg  ttctttact  agcccctgg  gtagatccc  gccccccac  taggtccct  20700
ggctggaaa  ggaagaggg  atgtttgga  gaatctgat  atgagccag  gaaggagct  20760
gcccctgag  ctgaggaga  ctgggtggc  gagacgctg  gtggcctca  gatgaaggc  20820
aagcgacgg  gagtgtcgc  cgtgctccc  gagtactac  aggccttca  caggctgct  20880
ggtaggagg  caccccaga  agcacctcc  atcctgttc  ttctaaaga  gaaacttcc  20940
ataaccaca  ttttccaat  ggaaaaata  gccccagtg  gtgagctct  catgcggga  21000
gactctgaa  tgatcactc  tgagggaca  ttaaggaga  aacagagga  taggtagac  21060
tgataaagg  cggtgcttg  gataagaaa  cttggtttt  ggccaggcg  tgtggctcc  21120
gcctgagat  ccagcacgt  gggaggctg  ggcaagagg  ttgcttgaa  tcaggactt  21180
gaggctgca  tgagctatg  ctgcaccac  gcactccag  ctgggtgac  gagcaaaac  21240
ctgcgtcaa  agaaaaacc  aggctgggc  cagtagctc  tccctgtag  tccagctac  21300
cgggaggct  agacaggag  actgcttaa  cccaggagg  agaggttgc  gtgagccaa  21360
atcaggcca  tgcattcca  cctggccca  agagcaaga  tctgtctca  aataaatta  21420
taaataaat  aaaataaaa  tcaaataaa  aaaaacaaa  tcaaaaatc  aaaaagtgg  21480
ttcagctgt  ccctctgaa  cttaatgtt  cttactgac  tttctaaac  taagtgtct  21540
catccatag  gagggatcc  aaggccatg  tcacaccct  atgtgtgac  gtctcatga  21600
gaaatgatg  gaattcctt  atgactctg  agtggtccc  ccgtgtctg  tggaggggg  21660
cctggctga  tcccagctc  acatcctgt  gattctcac  cccagggcc  ccttcggcc  21720
cttctcagg  gagtctcag  gcaggagcc  ctctccctt  cccagtgaa  gtcattctc  21780
cctctctca  ccacctcac  cgcggccac  atcctgaga  tttcccccg  gaggcacac  21840
tctcctcgc  gccctgctg  tctcacgga  accctgtcc  gcttctcac  ctgacatct  21900
ctctctaat  acagaggat  ctgtcatta  aagactcct  gcctgggac  aagatctga  21960
ggtgtcgga  aaggtaagg  tgttctcta  gtaactgtg  tcctgttct  acgcacggc  22020
agggggagg  cgcagcttc  aaacccaca  ttctccgtc  accacctcc  accagatgc  22080
cctacagtt  ttttttgtt  ttgtttttg  ttttttttg  gagacacag  cttgctctg  22140
tgcccaggc  ggagggcag  gtctcgatc  tgactcact  cagctgatg  ctcctgggt  22200
caagcgatt  tcccacctc  gcctccaag  agctgggat  acaaacatg  accaccacg  22260
ctggctaat  tttgtgttt  tagtagaga  ggggttttg  catgttggc  agattggtc  22320
cgaacacct  acctcaggt  atccacccg  cttggcctc  caaagtgct  agattacag  22380
cgtcagcac  gtgtctgac  agctcccat  gtcttgagt  ttggcaccc  cacattttt  22440
ttttctgag  cagagtcca  ctctgctcc  caggatgga  tacagtggc  tgatcatag  22500
tcactctaa  tcctgggct  aagcaatcc  ctttcctta  cctcctgag  agctgggac  22560
aggcacatg  taccatgct  aactaattt  tgaaatctt  ttagaaaca  ggtctcgct  22620
tgttgccca  gttgttctc  aactgttgg  ctcacatga  cctcctgtc  ccacctctc  22680
aaaagtact  ggatcacag  cttgagctg  cactcccgg  tattctttg  ctttttatg  22740
tttgtcagc  tctccgtca  gattctgct  gtctcttgc  gagtgaatg  gtggcccct  22800
cctctccta  gggtccttt  ggatctgag  cctgggcca  agtctggct  cagccctga  22860
gctcctggg  cctctactc  cagctcctt  ggacagttc  ctgcctggc  cacaaaaga  22920
cctcctgac  ccagccgac  tagacacac  ccctccaaa  atcccatcg  agcccacca  22980
cctgggagc  tcaccaaaa  cccttcctc  ggcttctcg  atttgcatc  gaccttcga  23040
tacccctcc  ccccgcaat  tccacatga  cacagtcac  ccaacactg  ggtcccttc  23100
ctgatgggc  acccctccc  agaccccca  tccactata  ccacaatct  cctctccca  23160
gatgtgaac  ctccctctc  gtgttcctt  ctctccatc  gtatctcct  gctatggtc  23220
tagcgtatt  cagccgggc  ggcctcccc  cctggcaat  ccaacgcat  catttcttc  23280
tggctctgt  agtggtttg  tgcctccta  ccgtcaata  ccaatgccc  gggacagcg  23340
gggaagtgg  attccagcc  ttcatttat  ctttcacct  tttgtcctc  ttactctgt  23400
tacaaaaaa  acaggatta  agtctcaaa  aaaaaaaaa  aagaacaaa  aacaaaagg  23460
accatgaac  gctcctaag  ggagaagaa  aggagcgga  gagcggaca  gacacttcc  23520
ccagcaagc  gacgtttcc  gttgttctc  ctccttccc  catcaaccg  aaaagccat  23580
agcctcctc  gggttcccg  gacagaggt  acagtccag  tcccccttg  atcactcga  23640
tccactgtc  aatgctccc  gctggggtt  cctggagtc  ctccccaag  cagggggct  23700
cctagtgca  cctgaacat  tttccaaag  acgacaacc  cactgccca  ctgaacaac  23760
tccttagct  atgtctttc  ctatcgagg  cagggtcca  agtgccaat  ccaccctct  23820
tacaatctc  acaaccaca  tggctcgcc  tcttggtgt  tcctggctt  gcttcactg  23880
tccttccaa  tgccctcca  ttgactttg  atttgtgtt  tctgtctgg  tgtcccgca  23940
acatgtggt  ctgaaggga  ggacccatt  cttgaagtc  gttcacccc  cagcctctg  24000
gatgccttc  ctcgtcttc  aacttctgc  tgcccgtag  tctccagtt  catcctatt  24060
taatgtgac  ttgggatta  gtcatctcc  ctgattact  ccagtccca  tagactaga  24120
gcctgtaga  ggcagggtc  tggcaaaat  tcagtgtat  caattgctt  ttttttttt  24180
ttgagacag  cttgccctg  cccctaagc  ggagtgcag  ggtgagatc  tagctcacc  24240
cagcctcca  atcctgggc  caagcgatc  tcccacctc  gcctcttga  tagctccga  24300
tacagggct  taccaccac  cctggacag  tatttattt  tttatttat  tatcaagac  24360
agagtgttg  tgtgtctct  aggctggaa  ggaggggcc  aatcttggc  cactgcaac  24420
tccgcctcc  gggttcaca  aattcttat  cttcagcct  ctgagtagc  aggactaat  24480
ggtgtgcca  cgcaccagg  tgatttttg  atttttagt  tagatgggg  ttctctgtg  24540
tgaccaggc  ggtctcaaa  tcctggtct  aagcaatcc  cctgcttca  ccttccaaa  24600
cgctgggat  acaggcatg  gccaccacg  ctggcgtat  ttttatatt  ttaatagag  24660
cgagggtct  gctatgttg  ccaggcctg  ctcaaactc  tggcctcaa  tgatcctcc  24720
gcttcggcc  cccagtgtg  tgggattcc  ggcataagc  accactctt  gtcaccagt  24780
gggtttttg  ctccatcct  aaggagtgg  agacgccct  gatcaggtc  ctgtccagc  24840
gagccctcc  gaggaaggc  tggctctct  cagggtggg  gccagtcct  agctaggga  24900
ggtccctta  cttcctctc  gagaagctg  cctcagccg  aggtctctc  tggtggtgc  24960
cctgagcag  aacctgatt  ctgtcctca  ctatctggc  aatgacatg  aggaggacg  25020
cgaggcccc  aaacaaaac  tcttctact  cctgtacga  gagacccgc  ctcatatac  25080
cttgctcag  gagctttgg  tccagttat  ccgttacat  aacccgagg  ccaggaaga  25140
ctgctctca  atagccttg  tccggaagt  tcggttcca  ttcttttgt  ccatgcgct  25200
cagggcttg  gtttccctg  aggagttgg  agaggtggg  ggggcctgg  gacgtggag  25260
atgtgggga  gaatcgggt  ggctggagg  tggacgagg  gagagaggg  tatcctggg  25320
agtccccgt  ttctcaaag  gcgtttgtt  ttccagatc  aggcttatg  cccagagca  25380
tgggtgtgg  cgcgagatc  cgcccacct  tcctagagc  ccagggacc  tggaggcct  25440
aggtcatcg  cctgagaga  ggtacatct  catcctccg  ggtaaaggc  gaatattgg  25500
gtctatttc  gaaatccaa  gaacccaat  gcttgatct  gcttcaagc  tgggcaacg  25560
ggcgagatc  cctctccac  aaaatacaa  aattagcca  gcgatgtgg  aggcatctc  25620
actcccaac  actcaggag  ctgaggcgg  aggatcgct  gagcctggg  ggtcggggc  25680
gcagggagc  ctgatcctg  cactgcact  cagcccggg  gacagagtg  gaccctgcc  25740
caaaaataa  cataaatac  gagttcggg  aggttcatt  tgattgatg  acttgagtt  25800
ccgatttgg  tcgagggtt  agtgaagct  tggtttaca  cttgtgcag  taaccatgt  25860
gagcacaga  catgagact  cgtcatgag  agggaggat  atggattag  cttctggac  25920
cgtggttcg  gatgctgtc  cgttagaaa  agatctagc  cggttacaa  tttagatct  25980
aagtgacac  aaaggcccc  gctgtgatg  agtccaaag  cacattctc  gagggtgcc  26040
tactccctg  gaagaccca  ccaaagtcc  ggctatgaa  cagatcact  gggctgacc  26100
tgggtgtat  aagttttgg  gtcagggtc  ccaaagtgt  agtttcaca  ttgaacacg  26160
tggttcaga  gcagggtat  gaatgaaag  caggagata  aattgcact  ctcaattgc  26220
ctgaactct  gctagactt  acatgggac  tgaataacc  tcctgtcta  agagctgcc  26280
ccttgaagt  tgacattgt  tctctcact  ccagaacac  ggacccagg  gagatgtgg  26340
ttttcagca  gaactttat  ccaatgcta  tggcagaca  caggaagga  gagaggaac  26400
attggtgca  atcatctag  agaacctgg  ccattcttg  cagagctga  tacagtgat  26460
acgttgtcc  ccaaggagc  ggggtgggg  ggggtactt  taggagtcc  tggagaaaa  26520
taagaaacc  ggagtgttt  cagttccac  ctttcctgc  gcaccacct  cctttttat  26580
ttgctgaat  ccaacctcc  tggggcgga  cctggaggt  ctgtttctt  tggacttgg  26640
tgccacagt  caggagcat  tgaaggcac  gtgcagggg  tcagattgg  acagaattc  26700
ttgtgaaat  tgagtgcca  agactgtaa  agatagctt  atgcacact  tgcatttta  26760
tggtttgtt  ggaaaatgt  ggccattga  ttattaata  gtttatttc  aatagtttg  26820
aaattgttg  acttttgaa  acatgctgt  cctgtagag  tttttgatg  gagttatag  26880
tgttatata  acctaaaga  aattttctt  tcattttta  gtgagaatt  tttttatcc  26940
aaatctttt  ttatcttta  atttttttc  gtattatta  atgtgctcc  gaagcgagc  27000
ctcttttta  ctatgatac  tccataata  tctcttcta  ttatagcta  tggtagttc  27060
ccaccagaa  aaaacataa  tctggtgat  gaaattttt  tttgctgtt  aggtttgtg  27120
ctgacttgt  agaattcag  tgtgatttt  aacatgtct  agatatata  actaacacg  27180
ctaatatat  ctatctatt  tattggttt  ttttgaaaa  catgggtat  gaattattt  27240
aatattatt  tatttactg  aatatttat  aaatatatt  atttattta  atattatta  27300
tactttaaa  attatttta  atattttgg  aatactggt  tttttgaat  gatgctgtt  27360
ctataaagc  gtgtgatgg  tattataac  gttgtatac  catacatat  attttgttt  27420
cctttttaa  agaggattc  tttcatcct  aatctttta  ctttcaatc  ttgtatcta  27480
tattacacg  gctgctgaa  ggagcatgg  ttttatcta  gatacttag  taacatata  27540
attacattt  tagctatgt  gtagttccc  taaattctt  taaaaataa  tttttattt  27600
atatttagt  tatgtttga  atgtgagaa  tcagatgga  ttttttatc  tgttttggc  27660
tgtttgtat  ttactttaa  gaggatgtg  gttctaaag  aggacatga  ctgtgtgtt  27720
tcaagagaa  agtgcagtg  atctcttgg  gaaacataa  aaagatgaa  ttttctcac  27780
ttcacagtg  gtgtgatca  attgtggtc  ggattgatt  tttgctgtc  agtgacatt  27840
ttccttaat  gggttgtgg  tatttgaac  tatttgtta  ctttggaag  taatcctgt  27900
ctgtttttt  tgtagaaaa  aacatacgg  tgggtgcag  gctcacacc  acaatccca  27960
cagttttgg  ggtcatggc  ggaggatca  ttgaagcct  tttttaatt  ttatttttt  28020
aagaaaaac  acagaagag  aggctgatc  caagctaca  ggttttttt  tttgtttgt  28080
tgtttgttt  ttttggaga  agtctcgct  tgtctccca  gctggagtg  agtggcaca  28140
cctcggctc  ctgcaactt  cacctcggc  ttcaagcaa  ttctcctgc  tcagcctcc  28200
aagtagctg  gactacagg  atccgcctg  acgtctgac  aacttttgt  aaaatagta  28260
agacaaggt  tcaccatgt  ggccaggct  gtctcaaac  cctgacctc  agtgatcca  28320
ccgcctcag  ctcccaaag  gctgggatt  taggcatga  ctactgtgc  cagacccca  28380
gctagagtt  taaagcagg  aatgagaga  agatattga  agaggaaaa  caggtggta  28440
gaaaactct  aaggtggct  ggcgtggtg  ctcacgcct  tgatcccag  aggagttcg  28500
gaccaggca  gagaatcac  agcagagaa  atgtctccc  aacccctct  aaaaaaaaa  28560
aaaaaaaag  ccaggcgcg  tggctcagg  ctgtaatcc  agcactttg  gaggctgag  28620
tgggtggat  atgaggtca  gagatcaag  ccatcctgg  taatacggt  aaaccccat  28680
tctgctaaa  atacaaaaa  ttagctggg  gcggtggca  gcgcctgta  tcccagcta  28740
tccggaggc  gaggcagga  aatggtgtg  acccaggag  cggagcctg  agtgagcag  28800
gatcgcgcc  ctgcactcc  gcctgggtg  aagcgcgag  ctccatcac  aaagaaaaa  28860
aaaaaaaga  agttcctgc  acagttcaa  ctgtgaaag  caggcactc  gccatgcaa  28920
tctttgtga  ttttctttt  tatttttgg  gtcggggtc  tgtgctgtc  cccagactg  28980
ggtgcagtg  tgcggtcat  gctcactgt  ggctcagac  caagctcaa  caatcttct  29040
atcttgcct  tctaattgc  gggattata  gcatgagcc  ctgcacctg  cctgtgtga  29100
gtaattctg  tgtcaactc  ctgatgtta  atcaaatgc  acaggttaa  gccaccagc  29160
cccgctagg  tgccctcgc  tcagatgca  ctgcaagct  gggtgtcca  agaccgcat  29220
tacttctca  caactggct  caaatttgg  ggttcccac  acgtcctca  gtttgataa  29280
tcaccataa  aacccacag  actctgaaa  gcatgatac  ttctctttc  ttatttgag  29340
cagagtctt  ctctgtcac  caggctgga  tgcagtggc  accatgctt  gctaatttt  29400
gtatttgta  tagagacag  gtttcgcca  gttggccag  ctggtcttg  actcctgac  29460
tcaggtgat  cacccacct  ggcctccca  agtgctggg  ttacaggca  agccactgt  29520
cctggctga  ttctagagt  tcaataaca  agatgtggt  caagaagaa  agggagaca  29580
gttttgtag  cagcaggag  ttcatgaaa  gaagccaat  aagggcagg  tgtgtagct  29640
tctacctac  ggaaaccag  caggagcct  cccacaggg  cttcagcac  gatggccgg  29700
aaaatctgc  ttcacctga  ctctggacc  aagagagga  aaggccttg  ctgtttcta  29760
agactcaca  gatgcaatc  ctgcggtcc  tgcccgtgg  gtgatctgg  aaacagggg  29820
ccttctaaa  gccaacaac  aggaaatca  atgtgcaac  gacagaaat  tcggcattg  29880
cacgggcca  ggagaggcc  aaacagatg  ctgcagtcc  ctgccaagg  catcaaagg  29940
gtgactctg  aataagaaa  ttcagacgc  acggcccaa  tagctgcac  aggtgggga  30000
gtcctccac  tgcctctgc  tccttcagt  cctcttcat  aaataagcc  aggtacttc  30060
ctggggaat  tcctttctc  ttctttctt  cgagacgga  tcttgctct  tcgcccagg  30120
tagagtgca  tggcgcgat  tcggctcac  gcaacctct  cctcccggg  tttggcaat  30180
cttctgtct  agacttctg  gtagctgag  ttacaggtg  gtgccacca  gcccagcta  30240
tatttgtat  ttcactcga  acagggttt  accatctag  ccaggctgg  cttgaactc  30300
tgacctcat  atccaccca  cttggcctc  caaagtcct  ggattacag  cacgagcca  30360
cacacccag  cttcttgtt  tattttttg  gatgaagtt  cgctcttgt  gcccaggct  30420
gagtgcaat  gcgagatct  agctcactg  cacctcctc  tcctcccag  ttcaagtga  30480
tatcctgcc  cagcctccc  agtagctgg  attacaggc  cccaacacc  aaccccgct  30540
actttttgt  tttttagta  agatggaat  tcaccatgt  ggccaggat  gtcttgaac  30600
cctgacctc  aatgatcta  ccgaattgg  ctcccaaaa  gctgggatt  caggcgtga  30660
ccactgtgc  cagcccctc  catacctct  ttggccaag  cagtacaat  cagagaatc  30720
tgccaggga  gactggtaa  tggacatca  catgatgcc  atggctcct  gtggattta  30780
atacctcct  gtgcttact  ataccttta  cagttacat  ggggctttt  catgccaga  30840
tgaaaatgc  ggagatcac  gatcaacct  caactattt  ctagcagaa  actgagggg  30900
ctctgcagt  accaatatc  cctattgca  ttggataaa  acctcccgg  aaatagaga  30960
gaatagaaa  gaaatactt  aacaagcag  atggctaca  tccttcaac  agaagggtc  31020
attagtctg  tttcacact  ctataaaga  ctactggaa  ctggggaat  tatgaagaa  31080
agaggttta  ttgactcac  gttttgcag  ctgtacagg  agcatggct  gggagccct  31140
aagaaactg  caatcacgg  agaaggcga  ggggaagca  gcacgtttc  ggccatggt  31200
gagcaggag  gacagagag  gtgaagcag  aggtgctgc  tgcttctaa  caaccagat  31260
ccatgagcg  tcactatca  gagaccagc  agggggacg  cagccgcca  gagccaatc  31320
tctcccacc  ggtccctcc  tcaacactg  gaattgcaa  tggacatga  atttggttg  31380
ggatacaga  ctgaaccat  tcaagggta  ttcaaccac  gagattgat  gattgactg  31440
gatggggtc  tgctctgtt  cctaggctg  agtgcagtg  cacaatctc  gctcactgc  31500
acctccgcc  cccaggttc  agcaattct  ctgcctcag  ctccctagt  gctgggact  31560
cagcacacg  caccacacc  ggctaattt  tgtattttc  gtagagacg  ggtttcacc  31620
tgtttgccc  gctggtctt  aactcctga  ctcgtgatc  ccctgcctc  gctcttctt  31680
tgctggaat  acaggcgtg  gccaccgca  ccggacaac  actgagatt  agaaggc  31737



<210> 7091
<211> 377
<212> DNA
<213> Rattus norvegicus
<308> AI179012
<400> 7091

gcgcaagtt  ggttttgtc  aagaaaggg  gtaaaacgc  gctcagtaa  agtccgcct  60
gaagcattt  cggtgcacg  tggaggggc  ggactcatc  tactcctgc  tgctgatcc  120
catctgctg  aaggtggac  gtgaggcca  gatagagcc  ccaatccac  cagagtact  180
gcgctcagg  ggagcaatg  tcttgatct  catggtgct  ggagccagg  cagtaatct  240
cttctgcat  ctgtcagca  tgcctgggt  catggtggt  ccaccagac  gcactgtgt  300
ggcatagag  tctttacgg  tgtcaacgt  acacttcat  atggaattg  atgtagttt  360
atggatgcc  caggatt  377



<210> 7092
<211> 375
<212> PRT
<213> Rattus norvegicus
<308> NP_112406
<400> 7092

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
  1               5                  10                  15
Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
             20                  25                  30
Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
         35                  40                  45
Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
     50                  55                  60
Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
 65                  70                  75                  80
Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                 85                  90                  95
Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
             100                105                110
Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
         115                120                125
Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
     130                135                140
Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
 145                150                155                160
His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                 165                170                175
Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
             180                185                190
Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
         195                200                205
Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
     210                215                220
Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
 225                230                235                240
Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                 245                250                255
Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
             260                265                270
Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
         275                280                285
Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
     290                295                300
Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
 305                310                315                320
Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                 325                330                335
Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
             340                345                350
Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
         355                360                365
Ile Val His Arg Lys Cys Phe 
     370                375



<210> 7093
<211> 767
<212> DNA
<213> Homo sapiens
<308> BE732178
<400> 7093

agagctcgc  tttgccgat  cgccgccgt  cacacccgc  gcagctcac  atggatgat  60
atatcgccg  gctcgtcgt  gacaacggc  ccggcatgt  caaggccgg  ttcgcgggc  120
acgatgccc  ccgggccgt  ttcccctcc  tcgtggggc  ccccaggca  cagggcgtg  180
tggtgggca  gggtcagaa  gattcctat  tgggcgacg  ggcccagag  aagagaggc  240
tcctcaccg  cgcgcggtg  ggttgtcta  tccacgctc  gagccatgc  gtccaaggg  300
ccgctgcag  ctgtgcagg  cttcggacg  aagaagaca  cgacagctg  ggcgcactg  360
aaacgcggc  atggtctca  caaggtgaa  gggcggccc  tggagatga  tgagccgcg  420
acgctacag  acaagctgc  ggagccagt  ctgcttctc  gcaaggagc  atttgctgg  480
gtagacatc  gtgtccgtg  aaagggtgg  ggtcacgtg  cccagattt  tgctatccg  540
cagtccatc  ccaaagccc  ggtggccta  taccagaaa  atgtggatg  ggcttccaa  600
aaggagatc  aagacatcc  catccagta  gaccggacc  tgctggtag  tgaccctcg  660
cgctgcgag  ccaaaaagt  tggaggcct  gtgcccgcg  tcgctacca  aaatctacc  720
ataagccca  cgtgactca  aactcactt  tataataac  gtttgag  767



<210> 7094
<211> 145
<212> PRT
<213> Homo sapiens
<308> P17008
<400> 7094

Pro Ser Lys Gly Pro Leu Gln Ser Val Gln Val Phe Gly Arg Lys Lys 
  1               5                  10                  15
Thr Ala Thr Ala Val Ala His Cys Lys Arg Gly Asn Gly Leu Ile Lys 
             20                  25                  30
Val Asn Gly Arg Pro Leu Glu Met Ile Glu Pro Arg Thr Leu Gln Tyr 
         35                  40                  45
Lys Leu Leu Glu Pro Val Leu Leu Leu Gly Lys Glu Arg Phe Ala Gly 
     50                  55                  60
Val Asp Ile Arg Val Arg Val Lys Gly Gly Gly His Val Ala Gln Ile 
 65                  70                  75                  80
Tyr Ala Ile Arg Gln Ser Ile Ser Lys Ala Leu Val Ala Tyr Tyr Gln 
                 85                  90                  95
Lys Tyr Val Asp Glu Ala Ser Lys Lys Glu Ile Lys Asp Ile Leu Ile 
             100                105                110
Gln Tyr Asp Arg Thr Leu Leu Val Ala Asp Pro Arg Arg Cys Glu Ser 
         115                120                125
Lys Lys Phe Gly Gly Pro Gly Ala Arg Ala Arg Tyr Gln Lys Ser Tyr 
     130                135                140
Arg 
 145



<210> 7095
<211> 589
<212> DNA
<213> Rattus norvegicus
<308> AI179399
<400> 7095

ttacttttt  taaaggtgg  cattgtcgt  gttttaatc  aaactgcca  attgaaaaa  60
attaagtca  ttaaacttg  gaattgtaa  taaaataaa  attctgaag  ataaggtgg  120
caggcactt  agatcatat  tacaaagct  atgcaggac  agccattac  tcaagagtc  180
caggatgaa  ttcaaacag  cacagttct  gtgttggtc  ttgatggta  tctcgatac  240
tctggactt  tgttacatg  aacaaactg  cccaatttc  aagccaaat  cctggtctg  300
attgccaat  tccacagga  cgatatcta  gatgggcaa  cgggccaca  tctgtgttc  360
gtattcaaa  acagtcttg  ctacatttc  atttcgctt  gaacaggta  cttgaagaa  420
ggtgtatct  aatctgatg  ttccttctc  ttttatttc  aagtcattt  accctttaa  480
aaccacagc  ttcttgagg  ttttagttt  atcatccat  taaccaaca  tgttccctc  540
tgccgaatt  ttggnctcg  gggccaaat  ccctatagt  agtcgtatt  589



<210> 7096
<211> 469
<212> PRT
<213> Rattus norvegicus
<308> CAA12180
<400> 7096

Leu Gly Pro Val Gly Pro Pro Gly Ser Asn Gly Pro Val Gly Glu Pro 
  1               5                  10                  15
Gly Pro Glu Gly Pro Ala Gly Asn Asp Gly Thr Pro Gly Arg Asp Gly 
             20                  25                  30
Ala Val Gly Glu Arg Gly Asp Arg Gly Asp Pro Gly Pro Ala Gly Leu 
         35                  40                  45
Pro Gly Ser Gln Gly Ala Pro Gly Thr Pro Gly Pro Val Gly Ala Pro 
     50                  55                  60
Gly Asp Ala Gly Gln Arg Gly Glu Pro Gly Ser Arg Gly Pro Val Gly 
 65                  70                  75                  80
Pro Pro Gly Arg Ala Gly Lys Arg Gly Leu Pro Gly Pro Gln Gly Pro 
                 85                  90                  95
Arg Gly Asp Lys Gly Asp Asn Gly Asp Arg Gly Asp Arg Gly Gln Lys 
             100                105                110
Gly His Arg Gly Phe Thr Gly Leu Gln Gly Leu Pro Gly Pro Pro Gly 
         115                120                125
Pro Asn Gly Glu Gln Gly Ser Ala Gly Ile Pro Gly Pro Phe Gly Pro 
     130                135                140
Arg Gly Pro Pro Gly Pro Val Gly Pro Ser Gly Lys Glu Gly Asn Pro 
 145                150                155                160
Gly Leu Leu Gly Pro Ile Gly Pro Pro Gly Val Arg Gly Ser Val Gly 
                 165                170                175
Glu Ala Gly Pro Glu Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly Pro 
             180                185                190
Pro Gly Pro Pro Gly His Leu Thr Ala Ala Leu Gly Asp Ile Met Gly 
         195                200                205
His Tyr Asp Glu Asn Met Pro Asp Pro Leu Pro Glu Phe Thr Glu Asp 
     210                215                220
Gln Ala Ala Pro Asp Asp Thr Asn Lys Thr Asp Pro Gly Val His Ser 
 225                230                235                240
Thr Leu Lys Ser Leu Ser Ser Gln Ile Glu Thr Met Arg Ser Pro Asp 
                 245                250                255
Gly Ser Lys Lys His Pro Ala Arg Thr Cys Asp Asp Leu Lys Leu Cys 
             260                265                270
His Pro Thr Lys Gln Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly 
         275                280                285
Ser Ala Glu Asp Ala Ile Lys Val Tyr Cys Asn Leu Glu Thr Gly Glu 
     290                295                300
Thr Cys Ile Ser Ala Asn Pro Ala Ser Val Pro Arg Lys Thr Trp Trp 
 305                310                315                320
Ala Ser Lys Ser Pro Asp Asn Lys Pro Val Trp Tyr Gly Phe Asp Met 
                 325                330                335
Asn Arg Gly Phe Gln Phe Thr Tyr Gly Asp Tyr Lys Ser Pro Asn Thr 
             340                345                350
Ala Ile Thr Gln Met Thr Phe Leu Arg Leu Leu Ser Lys Glu Ala Ser 
         355                360                365
Gln Asn Leu Thr Tyr Ile Cys Lys Asn Thr Val Gly Tyr Met Asp Asp 
     370                375                380
Gln Thr Lys Asn Leu Lys Lys Ala Val Val Leu Lys Gly Ser Asn Asp 
 385                390                395                400
Leu Glu Ile Lys Gly Glu Gly Asn Ile Arg Phe Arg Tyr Thr Val Leu 
                 405                410                415
Gln Asp Thr Cys Ser Lys Arg Asn Gly Asn Val Gly Lys Thr Val Phe 
             420                425                430
Glu Tyr Arg Thr Gln Asn Val Ala Arg Leu Pro Ile Ile Asp Ile Gly 
         435                440                445
Pro Val Asp Ile Gly Asn Ala Asp Gln Glu Phe Gly Phe Glu Ile Gly 
     450                455                460
Pro Val Cys Phe Met 
 465



<210> 7097
<211> 341
<212> DNA
<213> Homo sapiens
<308> AA348035
<400> 7097

aattcggcg  tgaaattgg  ccagtttgt  ttgtgtaaa  taagccaag  cacatcgnc  60
atgagcacc  ccatcaatg  ccaccgcca  tcacaagaa  tttgactgt  tgaagttga  120
cctgagact  ttgaagtaa  ggctgatcc  gcatcagca  tgtatatat  ggtcttaag  180
gcctggcct  cttatcctt  agaatattt  ttttnactt  caatcctca  gttttaatt  240
nttttaaat  tttttcant  caacagttt  aggnttaag  tgacccaat  acaatgacc  300
accttttgc  ggaaagtaa  acggattgg  ttaaataaa  c  341



<210> 7098
<211> 1496
<212> PRT
<213> Homo sapiens
<308> NP_000384
<400> 7098

Met Met Ala Asn Trp Ala Glu Ala Arg Pro Leu Leu Ile Leu Ile Val 
  1               5                  10                  15
Leu Leu Gly Gln Phe Val Ser Ile Lys Ala Gln Glu Glu Asp Glu Asp 
             20                  25                  30
Glu Gly Tyr Gly Glu Glu Ile Ala Cys Thr Gln Asn Gly Gln Met Tyr 
         35                  40                  45
Leu Asn Arg Asp Ile Trp Lys Pro Ala Pro Cys Gln Ile Cys Val Cys 
     50                  55                  60
Asp Asn Gly Ala Ile Leu Cys Asp Lys Ile Glu Cys Gln Asp Val Leu 
 65                  70                  75                  80
Asp Cys Ala Asp Pro Val Thr Pro Pro Gly Glu Cys Cys Pro Val Cys 
                 85                  90                  95
Ser Gln Thr Pro Gly Gly Gly Asn Thr Asn Phe Gly Arg Gly Arg Lys 
             100                105                110
Gly Gln Lys Gly Glu Pro Gly Leu Val Pro Val Val Thr Gly Ile Arg 
         115                120                125
Gly Arg Pro Gly Pro Ala Gly Pro Pro Gly Ser Gln Gly Pro Arg Gly 
     130                135                140
Glu Arg Gly Pro Lys Gly Arg Pro Gly Pro Arg Gly Pro Gln Gly Ile 
 145                150                155                160
Asp Gly Glu Pro Gly Val Pro Gly Gln Pro Gly Ala Pro Gly Pro Pro 
                 165                170                175
Gly His Pro Ser His Pro Gly Pro Asp Gly Leu Ser Arg Pro Phe Ser 
             180                185                190
Ala Gln Met Ala Gly Leu Asp Glu Lys Ser Gly Leu Gly Ser Gln Val 
         195                200                205
Gly Leu Met Pro Gly Ser Val Gly Pro Val Gly Pro Arg Gly Pro Gln 
     210                215                220
Gly Leu Gln Gly Gln Gln Gly Gly Ala Gly Pro Thr Gly Pro Pro Gly 
 225                230                235                240
Glu Pro Gly Asp Pro Gly Pro Met Gly Pro Ile Gly Ser Arg Gly Pro 
                 245                250                255
Glu Gly Pro Pro Gly Lys Pro Gly Glu Asp Gly Glu Pro Gly Arg Asn 
             260                265                270
Gly Asn Pro Gly Glu Val Gly Phe Ala Gly Ser Pro Gly Ala Arg Gly 
         275                280                285
Phe Pro Gly Ala Pro Gly Leu Pro Gly Leu Lys Gly His Arg Gly His 
     290                295                300
Lys Gly Leu Glu Gly Pro Lys Gly Glu Val Gly Ala Pro Gly Ser Lys 
 305                310                315                320
Gly Glu Ala Gly Pro Thr Gly Pro Met Gly Ala Met Gly Pro Leu Gly 
                 325                330                335
Pro Arg Gly Met Pro Gly Glu Arg Gly Arg Leu Gly Pro Gln Gly Ala 
             340                345                350
Pro Gly Gln Arg Gly Ala His Gly Met Pro Gly Lys Pro Gly Pro Met 
         355                360                365
Gly Pro Leu Gly Ile Pro Gly Ser Ser Gly Phe Pro Gly Asn Pro Gly 
     370                375                380
Met Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly Pro Glu Gly Pro 
 385                390                395                400
Gln Gly Gln Arg Gly Glu Thr Gly Pro Pro Gly Pro Val Gly Ser Pro 
                 405                410                415
Gly Leu Pro Gly Ala Ile Gly Thr Asp Gly Thr Pro Gly Pro Lys Gly 
             420                425                430
Pro Thr Gly Ser Pro Gly Thr Ser Gly Pro Pro Gly Ser Ala Gly Pro 
         435                440                445
Pro Gly Ser Pro Gly Pro Gln Gly Ser Thr Gly Pro Gln Gly Asn Ser 
     450                455                460
Gly Leu Pro Gly Asp Pro Gly Phe Lys Gly Glu Ala Gly Pro Lys Gly 
 465                470                475                480
Glu Pro Gly Pro His Gly Ile Gln Gly Pro Ile Gly Pro Pro Gly Glu 
                 485                490                495
Glu Gly Lys Arg Gly Pro Arg Gly Asp Pro Gly Thr Leu Gly Pro Pro 
             500                505                510
Gly Pro Val Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly Phe Pro Gly 
         515                520                525
Ser Asp Gly Leu Pro Gly Pro Lys Gly Ala Gln Gly Glu Arg Gly Pro 
     530                535                540
Val Gly Ser Ser Gly Pro Lys Gly Ser Gln Gly Asp Pro Gly Arg Pro 
 545                550                555                560
Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Thr Gly Asn Pro Gly 
                 565                570                575
Val Gln Gly Pro Glu Gly Lys Leu Gly Pro Leu Gly Ala Pro Gly Glu 
             580                585                590
Asp Gly Arg Pro Gly Pro Pro Gly Ser Ile Gly Ile Lys Gly Gln Pro 
         595                600                605
Gly Thr Met Gly Leu Pro Gly Pro Lys Gly Ser Asn Gly Asp Pro Gly 
     610                615                620
Lys Pro Gly Glu Ala Gly Asn Pro Gly Val Pro Gly Gln Arg Gly Ala 
 625                630                635                640
Pro Gly Lys Asp Gly Lys Val Gly Pro Tyr Gly Pro Pro Gly Pro Pro 
                 645                650                655
Gly Leu Arg Gly Glu Arg Gly Glu Gln Gly Pro Pro Gly Pro Thr Gly 
             660                665                670
Phe Gln Gly His Pro Gly Pro Pro Gly Pro Pro Gly Glu Gly Gly Lys 
         675                680                685
Pro Gly Asp Gln Gly Val Pro Gly Gly Pro Gly Ala Val Gly Pro Leu 
     690                695                700
Gly Pro Arg Gly Glu Arg Gly Asn Pro Gly Glu Arg Gly Glu Pro Gly 
 705                710                715                720
Ile Thr Gly Leu Pro Gly Glu Lys Gly Met Ala Gly Gly His Gly Pro 
                 725                730                735
Asp Gly Pro Lys Gly Ser Pro Gly Pro Ser Gly Thr Pro Gly Asp Thr 
             740                745                750
Gly Pro Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ile Ala Gly 
         755                760                765
Thr Pro Gly Pro Lys Gly Asp Arg Gly Gly Ile Gly Glu Lys Gly Ala 
     770                775                780
Glu Gly Thr Ala Gly Asn Asp Gly Ala Gly Gly Leu Pro Gly Pro Leu 
 785                790                795                800
Gly Pro Pro Gly Pro Ala Gly Leu Leu Gly Glu Lys Gly Glu Pro Gly 
                 805                810                815
Pro Arg Gly Leu Val Gly Pro Pro Gly Ser Arg Gly Asn Pro Gly Ser 
             820                825                830
Arg Gly Glu Asn Gly Pro Thr Gly Ala Val Gly Phe Ala Gly Pro Gln 
         835                840                845
Gly Ser Asp Gly Gln Pro Gly Val Lys Gly Glu Pro Gly Glu Pro Gly 
     850                855                860
Gln Lys Gly Asp Ala Gly Ser Pro Gly Pro Gln Gly Leu Ala Gly Ser 
 865                870                875                880
Pro Gly Pro His Gly Pro Asn Gly Val Pro Gly Leu Lys Gly Gly Arg 
                 885                890                895
Gly Thr Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ser Ala Gly 
             900                905                910
Arg Val Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Pro 
         915                920                925
Leu Gly Glu Pro Gly Lys Glu Gly Pro Pro Gly Pro Arg Gly Asp Pro 
     930                935                940
Gly Ser His Gly Arg Val Gly Val Arg Gly Pro Ala Gly Pro Pro Gly 
 945                950                955                960
Gly Pro Gly Asp Lys Gly Asp Pro Gly Glu Asp Gly Gln Pro Gly Pro 
                 965                970                975
Asp Gly Pro Pro Gly Pro Ala Gly Thr Thr Gly Gln Arg Gly Ile Val 
             980                985                990
Gly Met Pro Gly Gln Arg Gly Glu Arg Gly Met Pro Gly Leu Pro Gly 
         995                1000                1005
Pro Ala Gly Thr Pro Gly Lys Val Gly Pro Thr Gly Ala Thr Gly Asp 
     1010                1015                1020
Lys Gly Pro Pro Gly Pro Val Gly Pro Pro Gly Ser Asn Gly Pro Val 
 1025                1030                1035                1040
Gly Glu Pro Gly Pro Glu Gly Pro Ala Gly Asn Asp Gly Thr Pro Gly 
                 1045                1050                1055
Arg Asp Gly Ala Val Gly Glu Arg Gly Asp Arg Gly Asp Pro Gly Pro 
             1060                1065                1070
Ala Gly Leu Pro Gly Ser Gln Gly Ala Pro Gly Thr Pro Gly Pro Val 
         1075                1080                1085
Gly Ala Pro Gly Asp Ala Gly Gln Arg Gly Asp Pro Gly Ser Arg Gly 
     1090                1095                1100
Pro Ile Gly His Leu Gly Arg Ala Gly Lys Arg Gly Leu Pro Gly Pro 
 1105                1110                1115                1120
Gln Gly Pro Arg Gly Asp Lys Gly Asp His Gly Asp Arg Gly Asp Arg 
                 1125                1130                1135
Gly Gln Lys Gly His Arg Gly Phe Thr Gly Leu Gln Gly Leu Pro Gly 
             1140                1145                1150
Pro Pro Gly Pro Asn Gly Glu Gln Gly Ser Ala Gly Ile Pro Gly Pro 
         1155                1160                1165
Phe Gly Pro Arg Gly Pro Pro Gly Pro Val Gly Pro Ser Gly Lys Glu 
     1170                1175                1180
Gly Asn Pro Gly Pro Leu Gly Pro Leu Gly Pro Pro Gly Val Arg Gly 
 1185                1190                1195                1200
Ser Val Gly Glu Ala Gly Pro Glu Gly Pro Pro Gly Glu Pro Gly Pro 
                 1205                1210                1215
Pro Gly Pro Pro Gly Pro Pro Gly His Leu Thr Ala Ala Leu Gly Asp 
             1220                1225                1230
Ile Met Gly His Tyr Asp Glu Ser Met Pro Asp Pro Leu Pro Glu Phe 
         1235                1240                1245
Thr Glu Asp Gln Ala Ala Pro Asp Asp Lys Asn Lys Thr Asp Pro Gly 
     1250                1255                1260
Val His Ala Thr Leu Lys Ser Leu Ser Ser Gln Ile Glu Thr Met Arg 
 1265                1270                1275                1280
Ser Pro Asp Gly Ser Lys Lys His Pro Ala Arg Thr Cys Asp Asp Leu 
                 1285                1290                1295
Lys Leu Cys His Ser Ala Lys Gln Ser Gly Glu Tyr Trp Ile Asp Pro 
             1300                1305                1310
Asn Gln Gly Ser Val Glu Asp Ala Ile Lys Val Tyr Cys Asn Met Glu 
         1315                1320                1325
Thr Gly Glu Thr Cys Ile Ser Ala Asn Pro Ser Ser Val Pro Arg Lys 
     1330                1335                1340
Thr Trp Trp Ala Ser Lys Ser Pro Asp Asn Lys Pro Val Trp Tyr Gly 
 1345                1350                1355                1360
Leu Asp Met Asn Arg Gly Ser Gln Phe Ala Tyr Gly Asp His Gln Ser 
                 1365                1370                1375
Pro Asn Thr Ala Ile Thr Gln Met Thr Phe Leu Arg Leu Leu Ser Lys 
             1380                1385                1390
Glu Ala Ser Gln Asn Ile Thr Tyr Ile Cys Lys Asn Ser Val Gly Tyr 
         1395                1400                1405
Met Asp Asp Gln Ala Lys Asn Leu Lys Lys Ala Val Val Leu Lys Gly 
     1410                1415                1420
Ala Asn Asp Leu Asp Ile Lys Ala Glu Gly Asn Ile Arg Phe Arg Tyr 
 1425                1430                1435                1440
Ile Val Leu Gln Asp Thr Cys Ser Lys Arg Asn Gly Asn Val Gly Lys 
                 1445                1450                1455
Thr Val Phe Glu Tyr Arg Thr Gln Asn Val Ala Arg Leu Pro Ile Ile 
             1460                1465                1470
Asp Leu Ala Pro Val Asp Val Gly Gly Thr Asp Gln Glu Phe Gly Val 
         1475                1480                1485
Glu Ile Gly Pro Val Cys Phe Val 
     1490                1495



<210> 7099
<211> 438
<212> DNA
<213> Rattus norvegicus
<308> AI179445
<400> 7099

tagattgtt  ttggtccgt  actggtatg  acagtctct  tgactttgg  aaataacca  60
gagccaagt  catataata  agttgggat  cccatgttg  tgaccttga  cgcggtgaa  120
aagcggttt  gcgcggcca  gtcttgcca  ggcgccttg  agcaatggt  cttgatgaa  180
gggaagcag  cagtgcgca  gacgtggta  ttggcgccc  gcaccggcc  attgaagtg  240
gaaaggccg  actggtcgt  gtggaccgc  ctgtagggc  cgcagaagg  ggtccagtg  300
ggcaggcgc  gctgcagca  gtgccgcgt  agcacctcc  aggcgcggg  cttcgcctc  360
tgccgaatt  ttggcctcg  gggccaaat  ccctatagt  agtcgtatt  aattcgtaa  420
catgtcata  ctgtttcc  438



<210> 7100
<211> 466
<212> DNA
<213> Homo sapiens
<308> AI003932
<400> 7100

ttttttttt  catggcacc  tcatcttct  tattgagaa  ataaactgt  atgggtcca  60
aactggtat  cacagtctc  gtgactctg  caaataacc  ggagccaag  ccatataat  120
aagttggaa  acctcagga  gctgttatg  ctggtgaaa  cctttggtg  ttttagtaa  180
acgaacttg  cgggaattc  tacaaagaa  acaaaagaa  cttaaaaga  tagttccag  240
tattgcaac  taaacgcag  tgcaaagtg  tgttcacgg  aatgagtcc  gccatgcag  300
aggacggat  tcaacttca  agccacttt  tagggggcg  ttcctgacg  cgctggctt  360
ctgcccagg  caggggtct  ctctggtta  catgggcag  acaggaggg  gaccgctct  420
cctaggccc  aggacgcgc  cgcagcagg  gaacggctt  gggtgc  466



<210> 7101
<211> 438
<212> DNA
<213> Rattus norvegicus
<308> AI179445
<400> 7101

tagattgtt  ttggtccgt  actggtatg  acagtctct  tgactttgg  aaataacca  60
gagccaagt  catataata  agttgggat  cccatgttg  tgaccttga  cgcggtgaa  120
aagcggttt  gcgcggcca  gtcttgcca  ggcgccttg  agcaatggt  cttgatgaa  180
gggaagcag  cagtgcgca  gacgtggta  ttggcgccc  gcaccggcc  attgaagtg  240
gaaaggccg  actggtcgt  gtggaccgc  ctgtagggc  cgcagaagg  ggtccagtg  300
ggcaggcgc  gctgcagca  gtgccgcgt  agcacctcc  aggcgcggg  cttcgcctc  360
tgccgaatt  ttggcctcg  gggccaaat  ccctatagt  agtcgtatt  aattcgtaa  420
catgtcata  ctgtttcc  438



<210> 7102
<211> 466
<212> DNA
<213> Homo sapiens
<308> AI003932
<400> 7102

ttttttttt  catggcacc  tcatcttct  tattgagaa  ataaactgt  atgggtcca  60
aactggtat  cacagtctc  gtgactctg  caaataacc  ggagccaag  ccatataat  120
aagttggaa  acctcagga  gctgttatg  ctggtgaaa  cctttggtg  ttttagtaa  180
acgaacttg  cgggaattc  tacaaagaa  acaaaagaa  cttaaaaga  tagttccag  240
tattgcaac  taaacgcag  tgcaaagtg  tgttcacgg  aatgagtcc  gccatgcag  300
aggacggat  tcaacttca  agccacttt  tagggggcg  ttcctgacg  cgctggctt  360
ctgcccagg  caggggtct  ctctggtta  catgggcag  acaggaggg  gaccgctct  420
cctaggccc  aggacgcgc  cgcagcagg  gaacggctt  gggtgc  466



<210> 7103
<211> 520
<212> DNA
<213> Rattus norvegicus
<308> AI179916
<400> 7103

ggtgttgta  aatcaaagc  ctactttat  aaatgagtt  ttttacaca  tatgaacat  60
aatataatt  caattgtaa  aaaatttta  aacaagaat  gactgattt  tcagatttc  120
acatcagag  caactgtac  tttacacag  attgtcttt  catgaagcc  aaagggaac  180
gcataaaaa  gagtgtttc  gtagcccct  tattttttg  tgatcaaca  tttgtttaa  240
aaagcagct  caggtttgt  acctaatgt  tgagacagt  gaagagtcc  aggtgtcat  300
aattcacct  taaacaact  tatgcctga  catcagcca  ttctggagg  agtggagtc  360
tagggtgct  gctctcaaa  tgctgcttg  aggtcttgg  gtcaggcat  tgtgtccta  420
agactgtgc  ggtatatat  aaggcagct  tggcagcag  cttttggtc  tgtccttgt  480
tcttctttt  tccagcctg  tttttggca  ttttctgctg  520



<210> 7104
<211> 76
<212> PRT
<213> Rattus norvegicus
<308> BAB23156
<400> 7104

Met Ala Arg Gly Gln Gln Lys Ile Gln Ser Gln Gln Lys Asn Ala Lys 
  1               5                  10                  15
Lys Gln Ala Gly Gln Lys Lys Lys Gln Gly His Asp Gln Lys Ala Ala 
             20                  25                  30
Ala Lys Ala Ala Leu Ile Tyr Thr Cys Thr Val Cys Arg Thr Gln Met 
         35                  40                  45
Pro Asp Pro Lys Thr Phe Lys Gln His Phe Glu Ser Lys His Pro Lys 
     50                  55                  60
Thr Pro Leu Pro Pro Glu Leu Ala Asp Val Gln Ala 
 65                  70                  75



<210> 7105
<211> 412
<212> DNA
<213> Homo sapiens
<308> R77959
<400> 7105

tatcctgtg  ttttcgtaa  tcaaagtac  attttatta  atgagttat  ttacacaat  60
tgaacatca  tataattac  attgtaaaa  aatttttta  aacaaggat  gactgattt  120
catatttcc  aatcagagt  aactgtaca  ttacacaga  ttgtctttg  atgaagccc  180
agagggaac  gcataaaaa  gagtgtttc  gtagcccct  tatttttgc  gatcaacag  240
ttgttagaa  agcagctgc  gggtatgtt  cctaaggtc  gagacagta  gaagagtca  300
agggtgtca  gaattcacc  ggtaaacaa  cttatgcct  aacatcagc  aattctggg  360
gggnagtgg  agtcttagg  ntgcttgct  ttcaaagtg  tggcttgaa  gg  412



<210> 7106
<211> 76
<212> PRT
<213> Homo sapiens
<308> XP_018277
<400> 7106

Met Ala Arg Gly Gln Gln Lys Ile Gln Ser Gln Gln Lys Asn Ala Lys 
  1               5                  10                  15
Lys Gln Ala Gly Gln Lys Lys Lys Gln Gly His Asp Gln Lys Ala Ala 
             20                  25                  30
Ala Lys Ala Ala Leu Ile Tyr Thr Cys Thr Val Cys Arg Thr Gln Met 
         35                  40                  45
Pro Asp Pro Lys Thr Phe Lys Gln His Phe Glu Ser Lys His Pro Lys 
     50                  55                  60
Thr Pro Leu Pro Pro Glu Leu Ala Asp Val Gln Ala 
 65                  70                  75



<210> 7107
<211> 504
<212> DNA
<213> Rattus norvegicus
<308> AI180108
<400> 7107

atgtaaggt  ctcttttat  taaaagatc  ttcacaaaa  accatatcc  tagactcac  60
ttctgtcat  gaactgaat  tgttaagtg  ttggaattc  attcttaca  agtcagctg  120
gcgcccagc  gtgtggatg  acgtgcctg  tctgtcttt  ccgcattgg  gatggatta  180
atcatctga  agcatcagc  ttgattaca  ccacgcaat  catgtctgt  ttaagttag  240
tattggtgt  acacaaatg  ttcttatct  agaagcaga  aaaatggca  gcgagggaa  300
gagtgagag  tctgtaaat  gccgagacc  tgcgacaaa  acaatcatg  gccaagggg  360
ggctggcag  aagctgctg  ctaacgagc  agctgcgca  ctcagccct  ctttcccaa  420
gctctagtg  ctggctgac  cctacctgc  ccgactgga  cagatggag  ccctcgtgc  480
gaattcttg  cctcgaggg  caaa  504



<210> 7108
<211> 248
<212> PRT
<213> Rattus norvegicus
<308> AF139987
<400> 7108

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
  1               5                  10                  15
Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
             20                  25                  30
Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
         35                  40                  45
Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
     50                  55                  60
Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
 65                  70                  75                  80
Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                 85                  90                  95
Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
             100                105                110
Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
         115                120                125
Arg Lys Gly Gly Pro Asp Asp Arg Gly Met Gly Gly Ser Arg Glu Ser 
     130                135                140
Arg Gly Gly Trp Asp Ser Arg Asp Asp Phe Asn Ser Gly Tyr Arg Asp 
 145                150                155                160
Asp Phe Leu Gly Gly Arg Gly Gly Ser Arg Pro Gly Asp Arg Arg Ala 
                 165                170                175
Gly Pro Pro Met Gly Ser Arg Phe Arg Asp Gly Pro Pro Leu Arg Gly 
             180                185                190
Ser Asn Met Asp Phe Arg Glu Pro Thr Glu Glu Glu Arg Ala Gln Arg 
         195                200                205
Pro Arg Leu Gln Leu Lys Pro Arg Thr Val Ala Thr Pro Leu Asn Gln 
     210                215                220
Val Ala Asn Pro Asn Ser Ala Ile Phe Gly Gly Ala Arg Pro Arg Glu 
 225                230                235                240
Glu Val Val Gln Lys Glu Gln Glu 
                 245



<210> 7109
<211> 2477
<212> DNA
<213> Homo sapiens
<308> D26068
<400> 7109

gacggcaaa  ggcggactt  gacacctac  acgatcggg  ctacagcag  ttcggcggc  60
gcagagggt  ccgcggcag  gctggtggc  atggttccc  tagccagaa  gagttgccc  120
cagagcccc  ctacacagc  tacgtagga  atctacctt  caatacggt  cagggcgac  180
tagatgcta  ctttaagga  ctcagcata  ggagtgtac  gctagtcag  gacaaagac  240
cagataaat  taaaggatt  tgctatgta  aattcgatg  agtggattc  cttaaggaa  300
ccttgacat  cgatggtgc  ctgttgggc  atcggtcac  tcgtgtgga  attgcagaa  360
gcagaaaac  agataaagg  ggctttgga  tcagaaaag  tggaccaga  gacagaggc  420
tcagggatg  cttcttagg  ggcagggga  gtagtcgcc  aggcgaccg  cgaacaggc  480
cccccatgg  cagccgctt  agagatggc  ctcccctcc  tggatccaa  atggatttc  540
gagaaccca  agaagagga  agagcacag  gaccacgac  ccagcttaa  cctcgaaca  600
tcgcgacgc  cctcaatca  gtagccaat  ccaactctg  tatcttcgg  ggtgccagg  660
ctagagagg  agtcgttca  aaggagcaa  aatgagcct  cggttggga  ggaatgggg  720
gtggggggt  agagcagga  cacagcctg  tgagtcccc  ggcagccgt  ctgcagccg  780
cactcctgc  cctgccatt  gcctcctca  agcggaaac  cagcttgtg  gtgcatgtc  840
gctgttaac  agtggtttt  agtacattc  gggctttgc  gtatctatc  agtgcctgt  900
tgtgcgttt  tttctttct  ccgctgctt  cccattttc  ttctgtcct  tttctcctg  960
tccttgttt  cccagcagc  catggggtt  ctcggagga  cagaggtgg  cgccgtggg  1020
gggcgtttg  gctgcggtg  tgcgtcatt  ttcctttgc  ttctcttta  tttagacac  1080
ggcccaact  caggcgttt  ctttcattc  ctcagtgct  ctcttctga  ctgcatgtt  1140
agttctgta  tgctggggc  tccaacaaa  accagagtc  ctgacagag  gaacagcag  1200
gaccttgtt  gtattcagc  gtgatggat  tagagaatc  gaggcacct  gttttcaca  1260
ctaggataa  aatatctgc  gggtccttt  cattcctat  tagagggag  cctggctcc  1320
tgaccccct  ccgagtgga  tgtccaagc  gataggctc  cacgagaaa  agtgaggct  1380
aaagggggg  ctatggaag  gcggtaggg  gtccacgga  aagatgcag  gaatgcttg  1440
atgcattca  acgtgtgtg  gtcccagct  gttcactcc  ttcgccgtg  gtggtggag  1500
ctggcctct  tggctgggt  cagtgaatg  ccagcgggt  tcttttctg  tgggccaag  1560
cgctttggg  gtggagggg  tggtgctgg  gctgcactg  gctgactgc  gcgctgacg  1620
agcgtttcc  cccatccct  ttgcctgtg  gttgtgtgg  tctgttcct  gtataggca  1680
cataatgag  tactgtgct  cccacctcc  cttcagttc  gagccaaaa  gggtctaga  1740
tctggcttt  ctcatttcc  ttgataaat  gtactatgc  gagctgtca  gaaccttca  1800
atagcagta  aggactgca  ctgtctagg  ctgcggcca  atcttgggg  cacactgga  1860
tgttcccat  tgcagggtt  agcagttat  tgggagtgc  aggggttag  cttttgagc  1920
tgaacgcct  cgtgtgaac  gatgaaaaa  ccttcagta  ccaagtccc  gtctgtcct  1980
tggggagca  tttgggggc  gccggcagc  ggagcctgg  aaagaggcc  tcgccaggt  2040
atggcaggg  cagggtggc  tggggcacc  agcggaatg  gcttagtat  tggtcacca  2100
ccgtcatcc  gggcttttc  tactgtgtc  tgttacaag  cctcagcaa  ccacagaac  2160
ctctctcct  ccttccacc  gtcagcttc  ctgcttctg  gataagaac  atttgtgta  2220
caccaacac  taacttcag  aagacatgc  ttatgtggt  taatcaaac  cgatgcttt  2280
agatgacct  cttacatct  caatgtgga  aagataaag  acaaaacac  tgcatctaa  2340
ctgctgggc  atccagttg  cttttaaat  taagaatgg  attccaaac  cttaacaca  2400
tcagctata  gacagaaag  aaatctatg  atatggtat  ttgtgaatg  tcttttaaa  2460
aaaagaaaa  cttacgt  2477



<210> 7110
<211> 248
<212> PRT
<213> Homo sapiens
<308> Q15056
<400> 7110

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
  1               5                  10                  15
Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
             20                  25                  30
Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
         35                  40                  45
Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
     50                  55                  60
Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
 65                  70                  75                  80
Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                 85                  90                  95
Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
             100                105                110
Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
         115                120                125
Arg Lys Gly Gly Pro Asp Asp Arg Gly Met Gly Ser Ser Arg Glu Ser 
     130                135                140
Arg Gly Gly Trp Asp Ser Arg Asp Asp Phe Asn Ser Gly Phe Arg Asp 
 145                150                155                160
Asp Phe Leu Gly Gly Arg Gly Gly Ser Arg Pro Gly Asp Arg Arg Thr 
                 165                170                175
Gly Pro Pro Met Gly Ser Arg Phe Arg Asp Gly Pro Pro Leu Arg Gly 
             180                185                190
Ser Asn Met Asp Phe Arg Glu Pro Thr Glu Glu Glu Arg Ala Gln Arg 
         195                200                205
Pro Arg Leu Gln Leu Lys Pro Arg Thr Val Ala Thr Pro Leu Asn Gln 
     210                215                220
Val Ala Asn Pro Asn Ser Ala Ile Phe Gly Gly Ala Arg Pro Arg Glu 
 225                230                235                240
Glu Val Val Gln Lys Glu Gln Glu 
                 245



<210> 7111
<211> 417
<212> DNA
<213> Rattus norvegicus
<308> AI180288
<400> 7111

gaaagctgt  atattggtt  gttacaagg  cgtactatg  aatagaata  cgcagcaca  60
gaaagagtc  tctaccatt  gtgtgtctg  atacacgta  gcacataca  tacatagtt  120
ggttatcta  atgtggttc  gtctactat  gctaccaga  aaatccaca  agcaactaa  180
ctgaagaaa  aaatcagta  cactgtcag  taaaataat  acccaatct  ggtatgaat  240
agcatagaa  aaaagcaat  tgtcaacag  acatcttct  ttttaaaaa  aagacaatc  300
tcactgccc  atatcagat  tgaagtgga  cactttcag  gaattttga  tgcctactt  360
gataatttc  tccatgctt  agtctaaag  gcagaaaca  gatgtctgc  tcgtgcc  417



<210> 7112
<211> 181
<212> PRT
<213> Rattus norvegicus
<308> P02761
<400> 7112

Met Lys Leu Leu Leu Leu Leu Leu Cys Leu Gly Leu Thr Leu Val Cys 
  1               5                  10                  15
Gly His Ala Glu Glu Ala Ser Ser Thr Arg Gly Asn Leu Asp Val Ala 
             20                  25                  30
Lys Leu Asn Gly Asp Trp Phe Ser Ile Val Val Ala Ser Asn Lys Arg 
         35                  40                  45
Glu Lys Ile Glu Glu Asn Gly Ser Met Arg Val Phe Met Gln His Ile 
     50                  55                  60
Asp Val Leu Glu Asn Ser Leu Gly Phe Lys Phe Arg Ile Lys Glu Asn 
 65                  70                  75                  80
Gly Glu Cys Arg Glu Leu Tyr Leu Val Ala Tyr Lys Thr Pro Glu Asp 
                 85                  90                  95
Gly Glu Tyr Phe Val Glu Tyr Asp Gly Gly Asn Thr Phe Thr Ile Leu 
             100                105                110
Lys Thr Asp Tyr Asp Arg Tyr Val Met Phe His Leu Ile Asn Phe Lys 
         115                120                125
Asn Gly Glu Thr Phe Gln Leu Met Val Leu Tyr Gly Arg Thr Lys Asp 
     130                135                140
Leu Ser Ser Asp Ile Lys Glu Lys Phe Ala Lys Leu Cys Glu Ala His 
 145                150                155                160
Gly Ile Thr Arg Asp Asn Ile Ile Asp Leu Thr Lys Thr Asp Arg Cys 
                 165                170                175
Leu Gln Ala Arg Gly 
             180



<210> 7113
<211> 2198
<212> DNA
<213> Homo sapiens
<308> D90452
<400> 7113

caactgcgg  catgctggg  ggatccgga  cgcatggaa  acgcagcct  gccgcgctc  60
cccaaatcg  ctaccagag  aatgacgat  atgaagagg  ggcagcccg  gaacggcgc  120
gccgagccc  acaggaacg  ctgcggcag  agcaggagg  agaatcctt  ggacaggtg  180
ccgaccagg  ggaggtgaa  gcccagaac  gtgtgcctg  cgaggaggc  aagacaacc  240
ccacaaaca  tcaagtgga  ggggatgat  aggccgcat  cctggagcg  ctggctcgg  300
gtgaggaaa  acgccaaaa  cgccttcag  aggctctgg  gcggcagaa  gagttcgac  360
caacaataa  agatgcaag  ctgtcgctc  caagcagaa  aatgcaaaa  gacacagca  420
aaaatgaaa  taccgagaa  gaagaaaaa  gtgaaagtc  ccaagaaag  tacgagata  480
aggaaacag  aacagtcac  aagtcctac  agaagaatg  ttggaggga  gctgaagaa  540
acaagaaag  agacaagga  aaggaggag  aggaagagg  gaagccaaa  cgagggagc  600
ttggagaaa  tcagggaga  gagaaggga  ctaaagtgc  agctaaaag  gaaaagctc  660
aagaagaca  gcctacctt  aaaaaagaa  agatcaaag  tgaaaagat  aaaaaggac  720
aagaaccca  agaagaagt  aagagcttc  tggatcgaa  gaagggatt  acagaagtt  780
agtcgcaga  tggagaatt  atgacccac  aacttaaac  tactgagaa  actttcagc  840
gccctggag  gagggccag  gtggacacc  aggaggctg  gggcgcccc  caggtggaa  900
ccggcaaaa  gctggagga  cttcgtcgt  gtcgcgggg  gaccgagag  gaagagttc  960
agaagctca  acagaagca  caggaggcg  ctttggagc  ggaggaact  aagaaaaag  1020
gggaggaga  aaggaaggt  ctggaggag  aagagcaga  gaggaagca  gaggaagcc  1080
atcgaaaac  cagagagga  gaagagaag  ggaggctaa  ggaagagat  gaaaggcga  1140
gagcagaag  tgctgagaa  cgccagaag  tgccagaag  tggcttgtc  gatgacaag  1200
aaccattca  gtgtttcac  cctaaaggt  catctctca  gatagaaga  cgagcagaa  1260
ttttgaata  gtctgtgca  aaaagcagt  gtgtcaaat  gacccatca  gcagcaata  1320
tctccaaga  tgacagcag  ctggagcag  ataccagtg  aattgaggg  acaaaaagc  1380
caaaaccta  aaagccggc  gcctcggat  ttcctgttc  tgctgaagg  gtacgcaac  1440
tcaagagta  gtgggagaa  gggaatgtg  tttcatccc  cactgcagc  ggcacacca  1500
ataaggaaa  tgctggctt  aaggtaggg  tttctagcc  tatcaatga  tggctaact  1560
aaaccccag  tggaaacaa  tcacctgct  ccaaacctt  tgacttgag  ccaggagac  1620
tatccagca  gcggaacct  tgggaaaag  aatctgtgg  taaggtcac  tcccccact  1680
aggtttgag  cagttccag  aagaaccca  gctcaagac  caggacgag  tcagttgta  1740
agggctaat  cgctctttt  tatttatgt  gatttacta  attgggttc  ttatctttt  1800
tttttcaat  tcccagtaa  cccatgtat  ttatcacta  atttaataa  cacagctag  1860
gatgttcat  gtaaaagta  tgcctttgc  caggagcct  tttctaaag  aacccatgc  1920
gtgaaatag  gacttttct  ctgatcatc  taactctgt  tctgagcag  gataccaac  1980
acatctgaa  tcaacagaa  atccaagtt  aaaattgcc  gcggaatgt  tgcagtatc  2040
agaaaaatg  accgtagtt  tgttttttt  aatacagaa  tcatgttgt  tctgcactt  2100
ataataaag  atggaagaa  ttatcttag  aggcaattg  aacactttt  gaaagtaac  2160
catttcaga  ttgaaatac  gcaataatg  ttgtcttt  2198



<210> 7114
<211> 793
<212> PRT
<213> Homo sapiens
<308> Q05682
<400> 7114

Met Asp Asp Phe Glu Arg Arg Arg Glu Leu Arg Arg Gln Lys Arg Glu 
  1               5                  10                  15
Glu Met Arg Leu Glu Ala Glu Arg Ile Ala Tyr Gln Arg Asn Asp Asp 
             20                  25                  30
Asp Glu Glu Glu Ala Ala Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu 
         35                  40                  45
Arg Leu Arg Gln Lys Gln Glu Glu Glu Ser Leu Gly Gln Val Thr Asp 
     50                  55                  60
Gln Val Glu Val Asn Ala Gln Asn Ser Val Pro Asp Glu Glu Ala Lys 
 65                  70                  75                  80
Thr Thr Thr Thr Asn Thr Gln Val Glu Gly Asp Asp Glu Ala Ala Phe 
                 85                  90                  95
Leu Glu Arg Leu Ala Arg Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln 
             100                105                110
Glu Ala Leu Glu Arg Gln Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala 
         115                120                125
Ser Leu Ser Leu Pro Ser Arg Arg Met Gln Asn Asp Thr Ala Glu Asn 
     130                135                140
Glu Thr Thr Glu Lys Glu Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr 
 145                150                155                160
Glu Ile Glu Glu Thr Glu Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp 
                 165                170                175
Trp Arg Asp Ala Glu Glu Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu 
             180                185                190
Glu Glu Glu Glu Lys Pro Lys Arg Gly Ser Ile Gly Glu Asn Gln Val 
         195                200                205
Glu Val Met Val Glu Glu Lys Thr Thr Glu Ser Gln Glu Glu Thr Val 
     210                215                220
Val Met Ser Leu Lys Asn Gly Gln Ile Ser Ser Glu Glu Pro Lys Gln 
 225                230                235                240
Glu Glu Glu Arg Glu Gln Gly Ser Asp Glu Ile Ser His His Glu Lys 
                 245                250                255
Met Glu Glu Glu Asp Lys Glu Arg Ala Glu Ala Glu Arg Ala Arg Leu 
             260                265                270
Glu Ala Glu Glu Arg Glu Arg Ile Lys Ala Glu Gln Asp Lys Lys Ile 
         275                280                285
Ala Asp Glu Arg Ala Arg Ile Glu Ala Glu Glu Lys Ala Ala Ala Gln 
     290                295                300
Glu Arg Glu Arg Arg Glu Ala Glu Glu Arg Glu Arg Met Arg Glu Glu 
 305                310                315                320
Glu Lys Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys 
                 325                330                335
Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala 
             340                345                350
Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala Ala Glu 
         355                360                365
Glu Arg Gln Arg Ala Arg Ala Glu Glu Glu Glu Lys Ala Lys Val Glu 
     370                375                380
Glu Gln Lys Arg Asn Lys Gln Leu Glu Glu Lys Lys Arg Ala Met Gln 
 385                390                395                400
Glu Thr Lys Ile Lys Gly Glu Lys Val Glu Gln Lys Ile Glu Gly Lys 
                 405                410                415
Trp Val Asn Glu Lys Lys Ala Gln Glu Asp Lys Leu Gln Thr Ala Val 
             420                425                430
Leu Lys Lys Gln Gly Glu Glu Lys Gly Thr Lys Val Gln Ala Lys Arg 
         435                440                445
Glu Lys Leu Gln Glu Asp Lys Pro Thr Phe Lys Lys Glu Glu Ile Lys 
     450                455                460
Asp Glu Lys Ile Lys Lys Asp Lys Glu Pro Lys Glu Glu Val Lys Ser 
 465                470                475                480
Phe Met Asp Arg Lys Lys Gly Phe Thr Glu Val Lys Ser Gln Asn Gly 
                 485                490                495
Glu Phe Met Thr His Lys Leu Lys His Thr Glu Asn Thr Phe Ser Arg 
             500                505                510
Pro Gly Gly Arg Ala Ser Val Asp Thr Lys Glu Ala Glu Gly Ala Pro 
         515                520                525
Gln Val Glu Ala Gly Lys Arg Leu Glu Glu Leu Arg Arg Arg Arg Gly 
     530                535                540
Glu Thr Glu Ser Glu Glu Phe Glu Lys Leu Lys Gln Lys Gln Gln Glu 
 545                550                555                560
Ala Ala Leu Glu Leu Glu Glu Leu Lys Lys Lys Arg Glu Glu Arg Arg 
                 565                570                575
Lys Val Leu Glu Glu Glu Glu Gln Arg Arg Lys Gln Glu Glu Ala Asp 
             580                585                590
Arg Lys Leu Arg Glu Glu Glu Glu Lys Arg Arg Leu Lys Glu Glu Ile 
         595                600                605
Glu Arg Arg Arg Ala Glu Ala Ala Glu Lys Arg Gln Lys Met Pro Glu 
     610                615                620
Asp Gly Leu Ser Asp Asp Lys Lys Pro Phe Lys Cys Phe Thr Pro Lys 
 625                630                635                640
Gly Ser Ser Leu Lys Ile Glu Glu Arg Ala Glu Phe Leu Asn Lys Ser 
                 645                650                655
Val Gln Lys Ser Ser Gly Val Lys Ser Thr His Gln Ala Ala Ile Val 
             660                665                670
Ser Lys Ile Asp Ser Arg Leu Glu Gln Tyr Thr Ser Ala Ile Glu Gly 
         675                680                685
Thr Lys Ser Ala Lys Pro Thr Lys Pro Ala Ala Ser Asp Leu Pro Val 
     690                695                700
Pro Ala Glu Gly Val Arg Asn Ile Lys Ser Met Trp Glu Lys Gly Asn 
 705                710                715                720
Val Phe Ser Ser Pro Thr Ala Ala Gly Thr Pro Asn Lys Glu Thr Ala 
                 725                730                735
Gly Leu Lys Val Gly Val Ser Ser Arg Ile Asn Glu Trp Leu Thr Lys 
             740                745                750
Thr Pro Asp Gly Asn Lys Ser Pro Ala Pro Lys Pro Ser Asp Leu Arg 
         755                760                765
Pro Gly Asp Val Ser Ser Lys Arg Asn Leu Trp Glu Lys Gln Ser Val 
     770                775                780
Asp Lys Val Thr Ser Pro Thr Lys Val 
 785                790



<210> 7115
<211> 417
<212> DNA
<213> Rattus norvegicus
<308> AI180288
<400> 7115

gaaagctgt  atattggtt  gttacaagg  cgtactatg  aatagaata  cgcagcaca  60
gaaagagtc  tctaccatt  gtgtgtctg  atacacgta  gcacataca  tacatagtt  120
ggttatcta  atgtggttc  gtctactat  gctaccaga  aaatccaca  agcaactaa  180
ctgaagaaa  aaatcagta  cactgtcag  taaaataat  acccaatct  ggtatgaat  240
agcatagaa  aaaagcaat  tgtcaacag  acatcttct  ttttaaaaa  aagacaatc  300
tcactgccc  atatcagat  tgaagtgga  cactttcag  gaattttga  tgcctactt  360
gataatttc  tccatgctt  agtctaaag  gcagaaaca  gatgtctgc  tcgtgcc  417



<210> 7116
<211> 181
<212> PRT
<213> Rattus norvegicus
<308> P02761
<400> 7116

Met Lys Leu Leu Leu Leu Leu Leu Cys Leu Gly Leu Thr Leu Val Cys 
  1               5                  10                  15
Gly His Ala Glu Glu Ala Ser Ser Thr Arg Gly Asn Leu Asp Val Ala 
             20                  25                  30
Lys Leu Asn Gly Asp Trp Phe Ser Ile Val Val Ala Ser Asn Lys Arg 
         35                  40                  45
Glu Lys Ile Glu Glu Asn Gly Ser Met Arg Val Phe Met Gln His Ile 
     50                  55                  60
Asp Val Leu Glu Asn Ser Leu Gly Phe Lys Phe Arg Ile Lys Glu Asn 
 65                  70                  75                  80
Gly Glu Cys Arg Glu Leu Tyr Leu Val Ala Tyr Lys Thr Pro Glu Asp 
                 85                  90                  95
Gly Glu Tyr Phe Val Glu Tyr Asp Gly Gly Asn Thr Phe Thr Ile Leu 
             100                105                110
Lys Thr Asp Tyr Asp Arg Tyr Val Met Phe His Leu Ile Asn Phe Lys 
         115                120                125
Asn Gly Glu Thr Phe Gln Leu Met Val Leu Tyr Gly Arg Thr Lys Asp 
     130                135                140
Leu Ser Ser Asp Ile Lys Glu Lys Phe Ala Lys Leu Cys Glu Ala His 
 145                150                155                160
Gly Ile Thr Arg Asp Asn Ile Ile Asp Leu Thr Lys Thr Asp Arg Cys 
                 165                170                175
Leu Gln Ala Arg Gly 
             180



<210> 7117
<211> 2198
<212> DNA
<213> Homo sapiens
<308> D90452
<400> 7117

caactgcgg  catgctggg  ggatccgga  cgcatggaa  acgcagcct  gccgcgctc  60
cccaaatcg  ctaccagag  aatgacgat  atgaagagg  ggcagcccg  gaacggcgc  120
gccgagccc  acaggaacg  ctgcggcag  agcaggagg  agaatcctt  ggacaggtg  180
ccgaccagg  ggaggtgaa  gcccagaac  gtgtgcctg  cgaggaggc  aagacaacc  240
ccacaaaca  tcaagtgga  ggggatgat  aggccgcat  cctggagcg  ctggctcgg  300
gtgaggaaa  acgccaaaa  cgccttcag  aggctctgg  gcggcagaa  gagttcgac  360
caacaataa  agatgcaag  ctgtcgctc  caagcagaa  aatgcaaaa  gacacagca  420
aaaatgaaa  taccgagaa  gaagaaaaa  gtgaaagtc  ccaagaaag  tacgagata  480
aggaaacag  aacagtcac  aagtcctac  agaagaatg  ttggaggga  gctgaagaa  540
acaagaaag  agacaagga  aaggaggag  aggaagagg  gaagccaaa  cgagggagc  600
ttggagaaa  tcagggaga  gagaaggga  ctaaagtgc  agctaaaag  gaaaagctc  660
aagaagaca  gcctacctt  aaaaaagaa  agatcaaag  tgaaaagat  aaaaaggac  720
aagaaccca  agaagaagt  aagagcttc  tggatcgaa  gaagggatt  acagaagtt  780
agtcgcaga  tggagaatt  atgacccac  aacttaaac  tactgagaa  actttcagc  840
gccctggag  gagggccag  gtggacacc  aggaggctg  gggcgcccc  caggtggaa  900
ccggcaaaa  gctggagga  cttcgtcgt  gtcgcgggg  gaccgagag  gaagagttc  960
agaagctca  acagaagca  caggaggcg  ctttggagc  ggaggaact  aagaaaaag  1020
gggaggaga  aaggaaggt  ctggaggag  aagagcaga  gaggaagca  gaggaagcc  1080
atcgaaaac  cagagagga  gaagagaag  ggaggctaa  ggaagagat  gaaaggcga  1140
gagcagaag  tgctgagaa  cgccagaag  tgccagaag  tggcttgtc  gatgacaag  1200
aaccattca  gtgtttcac  cctaaaggt  catctctca  gatagaaga  cgagcagaa  1260
ttttgaata  gtctgtgca  aaaagcagt  gtgtcaaat  gacccatca  gcagcaata  1320
tctccaaga  tgacagcag  ctggagcag  ataccagtg  aattgaggg  acaaaaagc  1380
caaaaccta  aaagccggc  gcctcggat  ttcctgttc  tgctgaagg  gtacgcaac  1440
tcaagagta  gtgggagaa  gggaatgtg  tttcatccc  cactgcagc  ggcacacca  1500
ataaggaaa  tgctggctt  aaggtaggg  tttctagcc  tatcaatga  tggctaact  1560
aaaccccag  tggaaacaa  tcacctgct  ccaaacctt  tgacttgag  ccaggagac  1620
tatccagca  gcggaacct  tgggaaaag  aatctgtgg  taaggtcac  tcccccact  1680
aggtttgag  cagttccag  aagaaccca  gctcaagac  caggacgag  tcagttgta  1740
agggctaat  cgctctttt  tatttatgt  gatttacta  attgggttc  ttatctttt  1800
tttttcaat  tcccagtaa  cccatgtat  ttatcacta  atttaataa  cacagctag  1860
gatgttcat  gtaaaagta  tgcctttgc  caggagcct  tttctaaag  aacccatgc  1920
gtgaaatag  gacttttct  ctgatcatc  taactctgt  tctgagcag  gataccaac  1980
acatctgaa  tcaacagaa  atccaagtt  aaaattgcc  gcggaatgt  tgcagtatc  2040
agaaaaatg  accgtagtt  tgttttttt  aatacagaa  tcatgttgt  tctgcactt  2100
ataataaag  atggaagaa  ttatcttag  aggcaattg  aacactttt  gaaagtaac  2160
catttcaga  ttgaaatac  gcaataatg  ttgtcttt  2198



<210> 7118
<211> 793
<212> PRT
<213> Homo sapiens
<308> Q05682
<400> 7118

Met Asp Asp Phe Glu Arg Arg Arg Glu Leu Arg Arg Gln Lys Arg Glu 
  1               5                  10                  15
Glu Met Arg Leu Glu Ala Glu Arg Ile Ala Tyr Gln Arg Asn Asp Asp 
             20                  25                  30
Asp Glu Glu Glu Ala Ala Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu 
         35                  40                  45
Arg Leu Arg Gln Lys Gln Glu Glu Glu Ser Leu Gly Gln Val Thr Asp 
     50                  55                  60
Gln Val Glu Val Asn Ala Gln Asn Ser Val Pro Asp Glu Glu Ala Lys 
 65                  70                  75                  80
Thr Thr Thr Thr Asn Thr Gln Val Glu Gly Asp Asp Glu Ala Ala Phe 
                 85                  90                  95
Leu Glu Arg Leu Ala Arg Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln 
             100                105                110
Glu Ala Leu Glu Arg Gln Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala 
         115                120                125
Ser Leu Ser Leu Pro Ser Arg Arg Met Gln Asn Asp Thr Ala Glu Asn 
     130                135                140
Glu Thr Thr Glu Lys Glu Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr 
 145                150                155                160
Glu Ile Glu Glu Thr Glu Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp 
                 165                170                175
Trp Arg Asp Ala Glu Glu Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu 
             180                185                190
Glu Glu Glu Glu Lys Pro Lys Arg Gly Ser Ile Gly Glu Asn Gln Val 
         195                200                205
Glu Val Met Val Glu Glu Lys Thr Thr Glu Ser Gln Glu Glu Thr Val 
     210                215                220
Val Met Ser Leu Lys Asn Gly Gln Ile Ser Ser Glu Glu Pro Lys Gln 
 225                230                235                240
Glu Glu Glu Arg Glu Gln Gly Ser Asp Glu Ile Ser His His Glu Lys 
                 245                250                255
Met Glu Glu Glu Asp Lys Glu Arg Ala Glu Ala Glu Arg Ala Arg Leu 
             260                265                270
Glu Ala Glu Glu Arg Glu Arg Ile Lys Ala Glu Gln Asp Lys Lys Ile 
         275                280                285
Ala Asp Glu Arg Ala Arg Ile Glu Ala Glu Glu Lys Ala Ala Ala Gln 
     290                295                300
Glu Arg Glu Arg Arg Glu Ala Glu Glu Arg Glu Arg Met Arg Glu Glu 
 305                310                315                320
Glu Lys Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys 
                 325                330                335
Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala 
             340                345                350
Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala Ala Glu 
         355                360                365
Glu Arg Gln Arg Ala Arg Ala Glu Glu Glu Glu Lys Ala Lys Val Glu 
     370                375                380
Glu Gln Lys Arg Asn Lys Gln Leu Glu Glu Lys Lys Arg Ala Met Gln 
 385                390                395                400
Glu Thr Lys Ile Lys Gly Glu Lys Val Glu Gln Lys Ile Glu Gly Lys 
                 405                410                415
Trp Val Asn Glu Lys Lys Ala Gln Glu Asp Lys Leu Gln Thr Ala Val 
             420                425                430
Leu Lys Lys Gln Gly Glu Glu Lys Gly Thr Lys Val Gln Ala Lys Arg 
         435                440                445
Glu Lys Leu Gln Glu Asp Lys Pro Thr Phe Lys Lys Glu Glu Ile Lys 
     450                455                460
Asp Glu Lys Ile Lys Lys Asp Lys Glu Pro Lys Glu Glu Val Lys Ser 
 465                470                475                480
Phe Met Asp Arg Lys Lys Gly Phe Thr Glu Val Lys Ser Gln Asn Gly 
                 485                490                495
Glu Phe Met Thr His Lys Leu Lys His Thr Glu Asn Thr Phe Ser Arg 
             500                505                510
Pro Gly Gly Arg Ala Ser Val Asp Thr Lys Glu Ala Glu Gly Ala Pro 
         515                520                525
Gln Val Glu Ala Gly Lys Arg Leu Glu Glu Leu Arg Arg Arg Arg Gly 
     530                535                540
Glu Thr Glu Ser Glu Glu Phe Glu Lys Leu Lys Gln Lys Gln Gln Glu 
 545                550                555                560
Ala Ala Leu Glu Leu Glu Glu Leu Lys Lys Lys Arg Glu Glu Arg Arg 
                 565                570                575
Lys Val Leu Glu Glu Glu Glu Gln Arg Arg Lys Gln Glu Glu Ala Asp 
             580                585                590
Arg Lys Leu Arg Glu Glu Glu Glu Lys Arg Arg Leu Lys Glu Glu Ile 
         595                600                605
Glu Arg Arg Arg Ala Glu Ala Ala Glu Lys Arg Gln Lys Met Pro Glu 
     610                615                620
Asp Gly Leu Ser Asp Asp Lys Lys Pro Phe Lys Cys Phe Thr Pro Lys 
 625                630                635                640
Gly Ser Ser Leu Lys Ile Glu Glu Arg Ala Glu Phe Leu Asn Lys Ser 
                 645                650                655
Val Gln Lys Ser Ser Gly Val Lys Ser Thr His Gln Ala Ala Ile Val 
             660                665                670
Ser Lys Ile Asp Ser Arg Leu Glu Gln Tyr Thr Ser Ala Ile Glu Gly 
         675                680                685
Thr Lys Ser Ala Lys Pro Thr Lys Pro Ala Ala Ser Asp Leu Pro Val 
     690                695                700
Pro Ala Glu Gly Val Arg Asn Ile Lys Ser Met Trp Glu Lys Gly Asn 
 705                710                715                720
Val Phe Ser Ser Pro Thr Ala Ala Gly Thr Pro Asn Lys Glu Thr Ala 
                 725                730                735
Gly Leu Lys Val Gly Val Ser Ser Arg Ile Asn Glu Trp Leu Thr Lys 
             740                745                750
Thr Pro Asp Gly Asn Lys Ser Pro Ala Pro Lys Pro Ser Asp Leu Arg 
         755                760                765
Pro Gly Asp Val Ser Ser Lys Arg Asn Leu Trp Glu Lys Gln Ser Val 
     770                775                780
Asp Lys Val Thr Ser Pro Thr Lys Val 
 785                790



<210> 7119
<211> 520
<212> DNA
<213> Rattus norvegicus
<308> AI180396
<400> 7119

ggttggaga  tttaggttt  tattagtac  tggtaccat  gacacaaat  agaagattt  60
atagctatt  attatctac  catatcttt  ttaatcatt  ttatcaagt  attttttaa  120
ttggattaa  aatcctaag  agaaaattc  atttaaatt  gatcactgt  aacaaagtt  180
ctaggtgac  tcataccgt  ccaaagacc  agctgacaa  ctacagcct  gcactggcc  240
ccagagtgc  gtgcaaagt  cgtagaaac  tcttcgtac  gctactgta  ttttatatg  300
aaatatgtg  atttttcaa  aaagcactt  taaattagt  tctgtttag  tatattgaa  360
aggagcatt  ttttcctgc  taaatgaca  tcaatcatt  attggttca  ttcatctcc  420
ctaacacat  gtcattcac  atttaaata  ctgacttcg  cagaaaccg  ttgaacact  480
tttcttctt  ctgccataa  aatacagta  tttgcctttt  520



<210> 7120
<211> 1135
<212> PRT
<213> Rattus norvegicus
<308> O55081
<400> 7120

Met Ala Ser Gly Gly Asn Gln Ser Ser Pro Pro Pro Pro Ala Ala Ala 
  1               5                  10                  15
Ala Ser Ser Glu Glu Glu Glu Glu Asp Gly Asp Thr Ala Asp Arg Ala 
             20                  25                  30
Gln Pro Ala Gly Ser Pro Ser His Gln Ile Gln Gln Arg Phe Glu Glu 
         35                  40                  45
Leu Cys Ser Arg Leu Asn Met Asp Glu Ala Ala Arg Ala Glu Ala Trp 
     50                  55                  60
Ser Ser Tyr Arg Ser Met Ser Glu Ser Tyr Thr Leu Glu Gly Asn Asp 
 65                  70                  75                  80
Leu His Trp Leu Ala Cys Ala Leu Tyr Val Ala Cys Arg Lys Ser Val 
                 85                  90                  95
Pro Thr Val Ser Lys Gly Thr Ala Glu Gly Asn Tyr Val Ser Leu Thr 
             100                105                110
Arg Ile Leu Arg Cys Ser Glu Gln Ser Leu Ile Glu Phe Phe Asn Lys 
         115                120                125
Met Lys Lys Trp Glu Asp Met Ala Asn Leu Pro Pro His Phe Arg Glu 
     130                135                140
Arg Thr Glu Arg Leu Glu Arg Asn Phe Thr Val Ser Ala Val Ile Phe 
 145                150                155                160
Lys Lys Tyr Glu Pro Ile Phe Gln Asp Ile Phe Lys Tyr Pro Gln Glu 
                 165                170                175
Glu Gln Pro Arg Gln Gln Arg Gly Arg Lys Gln Arg Arg Gln Pro Cys 
             180                185                190
Thr Thr Ser Glu Ile Phe His Phe Cys Trp Val Leu Phe Ile Tyr Ala 
         195                200                205
Lys Gly Asn Phe Pro Met Ile Ser Asp Asp Leu Val Asn Ser Tyr His 
     210                215                220
Leu Leu Leu Cys Ala Leu Asp Leu Val Tyr Gly Asn Ala Leu Gln Cys 
 225                230                235                240
Ser Asn Arg Lys Glu Leu Val Asn Pro Asn Phe Lys Gly Val Ser Glu 
                 245                250                255
Asp Gly His Pro Arg Asp Ser His Pro Ser Ser Asp Pro Pro Cys Val 
             260                265                270
Ile Glu Lys Leu Cys Ser Leu His Asp Gly Leu Val Leu Glu Ala Lys 
         275                280                285
Gly Ile Lys Gln His Phe Trp Lys Pro Tyr Ile Arg Lys Leu Phe Glu 
     290                295                300
Lys Lys Leu Leu Arg Gly Lys Glu Glu Asn Leu Thr Gly Phe Leu Glu 
 305                310                315                320
Pro Gly Asn Phe Ala Glu Ser Phe Lys Ala Val Asn Lys Ala Tyr Glu 
                 325                330                335
Glu Tyr Val Leu Ala Thr Gly Ser Leu Asp Glu Arg Ile Phe Leu Gly 
             340                345                350
Glu Asp Ala Glu Glu Glu Val Gly Thr Phe Ser Arg Cys Val Ser Ala 
         355                360                365
Ala Ser Gly Thr Glu Ser Ala Glu Arg Thr Gln Met Arg Asp Ile Leu 
     370                375                380
Gln Gln His Leu Asp Lys Ser Lys Thr Leu Arg Val Cys Asn Pro Leu 
 385                390                395                400
Thr Gly Val Arg Tyr Val Gln Glu Asn Ser Pro Cys Val Thr Pro Val 
                 405                410                415
Ser Thr Ala Thr His Ser Leu Asn Arg Leu His Thr Met Leu Ala Gly 
             420                425                430
Leu Arg Asn Ala Pro Ser Glu Lys Leu Glu Gln Ile Leu Arg Ser Cys 
         435                440                445
Ser Arg Asp Pro Thr Arg Ala Ile Ala Asp Arg Leu Arg Glu Met Tyr 
     450                455                460
Glu Ile Tyr Ser Gln His Phe Gln Pro Asp Glu Asn Val Ser Asn Cys 
 465                470                475                480
Ala Lys Glu Met Ala Asn Lys His Phe Arg Phe Ala Glu Met Leu Tyr 
                 485                490                495
Tyr Lys Val Leu Glu Ser Val Ile Glu Gln Glu Gln Lys Arg Leu Gly 
             500                505                510
Asp Met Asp Leu Ser Gly Val Leu Glu Gln Asp Ala Phe His Lys Ser 
         515                520                525
Leu Leu Ala Cys Cys Leu Glu Val Val Ala Phe Ser Tyr Lys Pro Pro 
     530                535                540
Gly Asn Phe Pro Phe Ile Ala Glu Ile Phe Asp Val Pro His Tyr His 
 545                550                555                560
Phe Tyr Lys Val Ile Glu Val Phe Ile Arg Ala Glu Asp Gly Leu Cys 
                 565                570                575
Arg Glu Val Val Lys His Leu Asn Gln Ile Glu Glu Gln Ile Leu Asp 
             580                585                590
His Leu Ala Trp Lys Thr Lys Ser Pro Leu Trp Asp Arg Ile Arg Asp 
         595                600                605
Asn Glu Asn Arg Val Pro Thr Cys Glu Glu Val Thr Pro Pro His Asn 
     610                615                620
Leu Glu Arg Thr Asp Glu Ile Tyr Ile Ala Gly Ser Pro Leu Thr Pro 
 625                630                635                640
Arg Arg Val Gly Glu Val Arg Thr Asp Ala Gly Gly Leu Gly Arg Ser 
                 645                650                655
Val Thr Ser Pro Thr Thr Leu Tyr Asp Arg Tyr Ser Ser Pro Thr Val 
             660                665                670
Ser Thr Thr Arg Arg Arg Leu Phe Glu Ser Asp Ser Pro Ser Glu Gly 
         675                680                685
Ser Thr Ala Gly Arg Ile Pro Pro Gln Pro Leu Val Asn Ala Val Pro 
     690                695                700
Val Gln Asn Val Ser Gly Glu Thr Val Ser Val Thr Pro Val Pro Gly 
 705                710                715                720
Gln Thr Leu Val Thr Met Ala Thr Ala Thr Val Thr Ala Asn Asn Gly 
                 725                730                735
Gln Thr Val Thr Ile Pro Val Gln Gly Ile Ala Asn Glu Asn Gly Gly 
             740                745                750
Ile Thr Phe Phe Pro Val Gln Val Asn Val Gly Gly Gln Ala Gln Ala 
         755                760                765
Val Thr Gly Ser Ile Gln Pro Leu Ser Ala Gln Ala Leu Ala Gly Ser 
     770                775                780
Leu Ser Ser Gln Gln Val Thr Gly Thr Thr Leu Gln Val Pro Gly Pro 
 785                790                795                800
Val Ala Ile Gln Gln Ile Ser Pro Gly Gly Gln Gln Gln Asn Gln Gly 
                 805                810                815
Gln Pro Leu Thr Ser Ser Ser Ile Arg Pro Arg Lys Thr Ser Ser Leu 
             820                825                830
Ser Leu Phe Phe Arg Lys Val Tyr Tyr Leu Ala Gly Val Arg Leu Arg 
         835                840                845
Asp Leu Cys Thr Lys Leu Asp Ile Ser Asp Glu Leu Arg Lys Lys Ile 
     850                855                860
Trp Thr Cys Phe Glu Phe Ser Ile Val Gln Cys Pro Glu Leu Met Met 
 865                870                875                880
Asp Arg His Leu Asp Gln Leu Leu Met Cys Ala Ile Tyr Val Met Ala 
                 885                890                895
Lys Val Thr Lys Glu Asp Lys Ser Phe Gln Asn Ile Met Arg Cys Tyr 
             900                905                910
Arg Thr Gln Pro Gln Ala Arg Ser Gln Val Tyr Arg Ser Val Leu Ile 
         915                920                925
Lys Gly Lys Arg Arg Asn Ser Gly Ser Cys Glu Asn Arg Ser His Gln 
     930                935                940
Asn Ser Pro Thr Glu Leu Asn Thr Asp Arg Ala Ser Arg Asp Ser Ser 
 945                950                955                960
Pro Val Met Arg Ser Asn Ser Thr Leu Pro Val Pro Gln Pro Ser Ser 
                 965                970                975
Ala Pro Pro Thr Pro Thr Arg Leu Thr Gly Ala Asn Ser Asp Ile Glu 
             980                985                990
Glu Glu Glu Arg Gly Asp Leu Ile Gln Phe Tyr Asn Asn Ile Tyr Arg 
         995                1000                1005
Lys Gln Ile Gln Thr Phe Ala Met Lys Tyr Ser Gln Ala Asn Ser Gln 
     1010                1015                1020
Met Asp Thr Pro Pro Leu Ser Pro Tyr Pro Phe Val Arg Thr Gly Ser 
 1025                1030                1035                1040
Pro Arg Arg Val Gln Leu Ser Gln Ser His Pro Ile Tyr Ile Ser Pro 
                 1045                1050                1055
His Lys Asn Glu Ala Met Leu Ser Pro Arg Glu Lys Ile Phe Tyr Tyr 
             1060                1065                1070
Phe Ser Asn Ser Pro Ser Lys Arg Leu Arg Glu Ile Asn Ser Met Ile 
         1075                1080                1085
Arg Thr Gly Glu Thr Pro Thr Lys Lys Arg Gly Ile Leu Leu Asp Asp 
     1090                1095                1100
Gly Ser Glu Ser Pro Ala Lys Arg Ile Cys Pro Glu Asn His Ser Ala 
 1105                1110                1115                1120
Leu Leu Arg Arg Leu Gln Asp Val Ala Asn Asp Arg Gly Ser His 
                 1125                1130                1135



<210> 7121
<211> 1763
<212> DNA
<213> Homo sapiens
<308> AK023320
<400> 7121

atcaagcag  ggcagggct  gcgctgcgg  gggagatgc  gtcgggccg  ggcggcgct  60
ggcagccag  agctctgca  tgaaggcac  ggggtaaag  gaatgccga  gacagaaga  120
ttggatgat  caccactga  tttctttgt  tggaataca  gttatgaac  ctttctgga  180
catgtctac  agctctgta  gcaaacgat  tgaaggtga  gagaagaca  taacagggg  240
cgtgaaaac  agtcctcca  gaactgcac  aaagaaaca  ctgccttct  ttcccaaaa  300
tgctttgcc  ataactaag  ctacatctc  tgccccagc  gcacagtca  caaatggca  360
gcatgcgtc  tatggaccc  tctacctgg  atactctct  cttgcagaa  ttaccttgg  420
tgtgaagca  aagctacca  gcgtctatg  gcagccatc  tatcgctct  cattaatgt  480
gtttggagt  atattcata  ggcatggac  ttaccaaga  ggcgtattt  agtttacag  540
ttacatccc  gataactat  cagatggtg  ctgtccacg  ttggtgttc  atattcctg  600
ctttcaccc  ctagttgat  ccacctcag  tgagctgga  gtgaagaga  catttgcaa  660
atggaggcg  aaccataat  atatttggc  ggtattaat  tatgcaagg  gagttttct  720
caagattga  acagcaagc  ccctgaacc  agaggctgc  gtactgtat  aaaaagata  780
tcagctttt  aaaagtaaa  ttgttgaca  tgttaaggt  tgcactgct  gtttgtttg  840
ccaacctaa  atagaagac  cctatgcaa  tagcttttc  ccatggaat  cttctgtac  900
tgatgaagc  agagaaaag  tgctgactc  gaaaaagcc  gaagaacag  acaataaaa  960
tgttcatgt  gctggcctg  catgggtaa  gcctggctc  gtacagcct  tcagtaaag  1020
agagaaaac  gtggcgact  aagagatgg  gaatctggt  caccatgca  tttcctgct  1080
gactctggc  tagttcaag  tgaccaatg  cagaggact  cctgaagag  aaaactgtg  1140
gaacaatga  tgactgcca  tgttttcca  gtatgcata  gttctaaca  cagggtttg  1200
aaacctgtc  ctaagtaat  cattacttc  gtcagaagt  tcttagggt  gttatctag  1260
tcagtactc  aaattattg  ggaccttga  gcttaagta  gtatttttc  gaatataat  1320
ctaaaggta  gttgcattc  tttaaacta  tagagcaga  agaattcag  actacttaa  1380
agtttataa  tcagtggtt  cagttgtat  tatgttagg  aatggagag  tatagagag  1440
gcaggttcc  tagctcagc  cttttaagt  gaagatcat  tgaatctca  tcttcagcc  1500
gcactgatt  gtagcctgc  ctgtcttac  gatttacaa  ctgaaatca  tgagaaatg  1560
ctttagttc  gtgagaaga  accagaaca  ttgttccta  tgttgtgtt  tttttttta  1620
gcaaattac  tactgtatt  ttatggcag  agggagaaa  agtgttaca  cggcttcta  1680
tgaagtccg  tatttaaat  ataaatgac  aatgtgttt  gtagagaca  aataaacca  1740
taaatgatt  ttctttgcc  ttt  1763



<210> 7122
<211> 1139
<212> PRT
<213> Homo sapiens
<308> CAA53661
<400> 7122

Met Pro Ser Gly Gly Asp Gln Ser Pro Pro Pro Pro Pro Pro Pro Pro 
  1               5                  10                  15
Ala Ala Ala Ala Ser Asp Glu Glu Glu Glu Asp Asp Gly Glu Ala Glu 
             20                  25                  30
Asp Ala Ala Pro Ser Ala Glu Ser Pro Thr Pro Gln Ile Gln Gln Arg 
         35                  40                  45
Phe Asp Glu Leu Cys Ser Arg Leu Asn Met Asp Glu Ala Ala Arg Ala 
     50                  55                  60
Glu Ala Trp Asp Ser Tyr Arg Ser Met Ser Glu Ser Tyr Thr Leu Glu 
 65                  70                  75                  80
Gly Asn Asp Leu His Trp Leu Ala Cys Ala Leu Tyr Val Ala Cys Arg 
                 85                  90                  95
Lys Ser Val Pro Thr Val Ser Lys Gly Thr Val Glu Gly Asn Tyr Val 
             100                105                110
Ser Leu Thr Arg Ile Leu Lys Cys Ser Glu Gln Ser Leu Ile Glu Phe 
         115                120                125
Phe Asn Lys Met Lys Lys Trp Glu Asp Met Ala Asn Leu Pro Pro His 
     130                135                140
Phe Arg Glu Arg Thr Glu Arg Leu Glu Arg Asn Phe Thr Val Ser Ala 
 145                150                155                160
Val Ile Phe Lys Lys Tyr Glu Pro Ile Phe Gln Asp Ile Phe Lys Tyr 
                 165                170                175
Pro Gln Glu Glu Gln Pro Arg Gln Gln Arg Gly Arg Lys Gln Arg Arg 
             180                185                190
Gln Pro Cys Thr Val Ser Glu Ile Phe His Phe Cys Trp Val Leu Phe 
         195                200                205
Ile Tyr Ala Lys Gly Asn Phe Pro Met Ile Ser Asp Asp Leu Val Asn 
     210                215                220
Ser Tyr His Leu Leu Leu Cys Ala Leu Asp Leu Val Tyr Gly Asn Ala 
 225                230                235                240
Leu Gln Cys Ser Asn Arg Lys Glu Leu Val Asn Pro Asn Phe Lys Gly 
                 245                250                255
Leu Ser Glu Asp Phe His Ala Lys Asp Ser Lys Pro Ser Ser Asp Pro 
             260                265                270
Pro Cys Ile Ile Glu Lys Leu Cys Ser Leu His Asp Gly Leu Val Leu 
         275                280                285
Glu Ala Lys Gly Ile Lys Glu His Phe Trp Lys Pro Tyr Ile Arg Lys 
     290                295                300
Leu Tyr Glu Lys Lys Leu Leu Lys Gly Lys Glu Glu Asn Leu Thr Gly 
 305                310                315                320
Phe Leu Glu Pro Gly Asn Phe Gly Glu Ser Phe Lys Ala Ile Asn Lys 
                 325                330                335
Ala Tyr Glu Glu Tyr Val Leu Ser Val Gly Asn Leu Asp Glu Arg Ile 
             340                345                350
Phe Leu Gly Glu Asp Ala Glu Glu Glu Ile Gly Thr Leu Ser Arg Cys 
         355                360                365
Leu Asn Ala Gly Ser Gly Thr Glu Thr Ala Glu Arg Val Gln Met Lys 
     370                375                380
Asn Ile Leu Gln Gln His Phe Asp Lys Ser Lys Ala Leu Arg Ile Ser 
 385                390                395                400
Thr Pro Leu Thr Gly Val Arg Tyr Ile Lys Glu Asn Ser Pro Cys Val 
                 405                410                415
Thr Pro Val Ser Thr Ala Thr His Ser Leu Ser Arg Leu His Thr Met 
             420                425                430
Leu Thr Gly Leu Arg Asn Ala Pro Ser Glu Lys Leu Glu Gln Ile Leu 
         435                440                445
Arg Thr Cys Ser Arg Asp Pro Thr Gln Ala Ile Ala Asn Arg Leu Lys 
     450                455                460
Glu Met Phe Glu Ile Tyr Ser Gln His Phe Gln Pro Asp Glu Asp Phe 
 465                470                475                480
Ser Asn Cys Ala Lys Glu Ile Ala Ser Lys His Phe Arg Phe Ala Glu 
                 485                490                495
Met Leu Tyr Tyr Lys Val Leu Glu Ser Val Ile Glu Gln Glu Gln Lys 
             500                505                510
Arg Leu Gly Asp Met Asp Leu Ser Gly Ile Leu Glu Gln Asp Ala Phe 
         515                520                525
His Arg Ser Leu Leu Ala Cys Cys Leu Glu Val Val Thr Phe Ser Tyr 
     530                535                540
Lys Pro Pro Gly Asn Phe Pro Phe Ile Thr Glu Ile Phe Asp Val Pro 
 545                550                555                560
Leu Tyr His Phe Tyr Lys Val Ile Glu Val Phe Ile Arg Ala Glu Asp 
                 565                570                575
Gly Leu Cys Arg Glu Val Val Lys His Leu Asn Gln Ile Glu Glu Gln 
             580                585                590
Ile Leu Asp His Leu Ala Trp Lys Pro Glu Ser Pro Leu Trp Glu Lys 
         595                600                605
Ile Arg Asp Asn Glu Asn Arg Val Pro Thr Cys Glu Glu Val Met Pro 
     610                615                620
Pro Gln Asn Leu Glu Arg Ala Asp Glu Ile Cys Ile Ala Gly Ser Pro 
 625                630                635                640
Leu Thr Pro Arg Arg Val Thr Glu Val Arg Ala Asp Thr Gly Gly Leu 
                 645                650                655
Gly Arg Ser Ile Thr Ser Pro Thr Thr Leu Tyr Asp Arg Tyr Ser Ser 
             660                665                670
Pro Pro Ala Ser Thr Thr Arg Arg Arg Leu Phe Val Glu Asn Asp Ser 
         675                680                685
Pro Ser Asp Gly Gly Thr Pro Gly Arg Met Pro Pro Gln Pro Leu Val 
     690                695                700
Asn Ala Val Pro Val Gln Asn Val Ser Gly Glu Thr Val Ser Val Thr 
 705                710                715                720
Pro Val Pro Gly Gln Thr Leu Val Thr Met Ala Thr Ala Thr Val Thr 
                 725                730                735
Ala Asn Asn Gly Gln Thr Val Thr Ile Pro Val Gln Gly Ile Ala Asn 
             740                745                750
Glu Asn Gly Gly Ile Thr Phe Phe Pro Val Gln Val Asn Val Gly Gly 
         755                760                765
Gln Ala Gln Ala Val Thr Gly Ser Ile Gln Pro Leu Ser Ala Gln Ala 
     770                775                780
Leu Ala Gly Ser Leu Ser Ser Gln Gln Val Thr Gly Thr Thr Leu Gln 
 785                790                795                800
Val Pro Gly Gln Val Ala Ile Gln Gln Ile Ser Pro Gly Gly Gln Gln 
                 805                810                815
Gln Lys Gln Gly Gln Ser Val Thr Ser Ser Ser Asn Arg Pro Arg Lys 
             820                825                830
Thr Ser Ser Leu Ser Leu Phe Phe Arg Lys Val Tyr His Leu Ala Ala 
         835                840                845
Val Arg Leu Arg Asp Leu Cys Ala Lys Leu Asp Ile Ser Asp Glu Leu 
     850                855                860
Arg Lys Lys Ile Trp Thr Cys Phe Glu Phe Ser Ile Ile Gln Cys Pro 
 865                870                875                880
Glu Leu Met Met Asp Arg His Leu Asp Gln Leu Leu Met Cys Ala Ile 
                 885                890                895
Tyr Val Met Ala Lys Val Thr Lys Glu Asp Lys Ser Phe Gln Asn Ile 
             900                905                910
Met Arg Cys Tyr Arg Thr Gln Pro Gln Ala Arg Ser Gln Val Tyr Arg 
         915                920                925
Ser Val Leu Ile Lys Gly Lys Arg Lys Arg Arg Asn Ser Gly Ser Ser 
     930                935                940
Asp Ser Arg Ser His Gln Asn Ser Pro Thr Glu Leu Asn Lys Asp Arg 
 945                950                955                960
Thr Ser Arg Asp Ser Ser Pro Val Met Arg Ser Ser Ser Thr Leu Pro 
                 965                970                975
Val Pro Gln Pro Ser Ser Ala Pro Pro Thr Pro Thr Arg Leu Thr Gly 
             980                985                990
Ala Asn Ser Asp Met Glu Glu Glu Glu Arg Gly Asp Leu Ile Gln Phe 
         995                1000                1005
Tyr Asn Asn Ile Tyr Ile Lys Gln Ile Lys Thr Phe Ala Met Lys Tyr 
     1010                1015                1020
Ser Gln Ala Asn Met Asp Ala Pro Pro Leu Ser Pro Tyr Pro Phe Val 
 1025                1030                1035                1040
Arg Thr Gly Ser Pro Arg Arg Ile Gln Leu Ser Gln Asn His Pro Val 
                 1045                1050                1055
Tyr Ile Ser Pro His Lys Asn Glu Thr Met Leu Ser Pro Arg Glu Lys 
             1060                1065                1070
Ile Phe Tyr Tyr Phe Ser Asn Ser Pro Ser Lys Arg Leu Arg Glu Ile 
         1075                1080                1085
Asn Ser Met Ile Arg Thr Gly Glu Thr Pro Thr Lys Lys Arg Gly Ile 
     1090                1095                1100
Leu Leu Glu Asp Gly Ser Glu Ser Pro Ala Lys Arg Ile Cys Pro Glu 
 1105                1110                1115                1120
Asn His Ser Ala Leu Leu Arg Arg Leu Gln Asp Val Ala Asn Asp Arg 
                 1125                1130                1135
Gly Ser His 
             1140



<210> 7123
<211> 698
<212> DNA
<213> Rattus norvegicus
<308> AI180424
<400> 7123

ccattcata  aacttttat  ccacttaca  gaactttaa  acatgtgtt  ttaacaatt  60
tgcttggat  gttcatgaa  atttcataa  acattaaaa  aaagctagc  gtcatctca  120
gttatttcc  tgttaacta  ttttacagc  catgcatgt  aggcaagta  caaaaagag  180
aaaaaaatc  caaaagcaa  aacaaaaca  aacaaaaaa  ttaaaaaaa  aagttaaat  240
catgggatt  tgtttaccg  tgtgcttga  ccgcatgga  ccgggaaca  caagcaact  300
gtttgtact  catctttac  tttacattt  ttcttagat  gcctaaaac  tttaaatac  360
aataaaatg  gtagcaaaa  taatgaaag  aaacagcag  taactttac  aataatgga  420
tgtgaaccg  ttctgccct  atcagagta  attgggtca  aactttgtc  acagacaac  480
tctggagct  tggtcaagg  tgtgcacgc  gacacacgg  cttagcgtg  atccacagg  540
tgttcgtgt  ccagcctca  aagtgctcc  agccttaca  tacccacac  gactacact  600
atgactgga  ccattatcc  gtttattcc  cgccagctc  caccaatat  taagcagtt  660
tctttgctt  gacatggaa  cagtttgaa  actggccc  698



<210> 7124
<211> 245
<212> PRT
<213> Rattus norvegicus
<308> P35215
<400> 7124

Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala 
  1               5                  10                  15
Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln 
             20                  25                  30
Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
         35                  40                  45
Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser 
     50                  55                  60
Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg 
 65                  70                  75                  80
Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp 
                 85                  90                  95
Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Pro 
             100                105                110
Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr 
         115                120                125
Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln 
     130                135                140
Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met 
 145                150                155                160
Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                 165                170                175
Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala 
             180                185                190
Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu 
         195                200                205
Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
     210                215                220
Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly 
 225                230                235                240
Glu Gly Gly Glu Asn 
                 245



<210> 7125
<211> 446
<212> DNA
<213> Homo sapiens
<308> AW674116
<400> 7125

acttgatac  ttaagtgaa  agtcataca  agacagcac  ctaataatg  aattactga  60
agacaactt  acattgtgg  catcggata  ccaaggaga  gaagctgaa  caggagaag  120
aggggaaaa  taaccggcc  tccaacttt  gtctgcctc  ttctaaaat  tacacagta  180
accatttgt  atccatgct  tcccaaaat  gtntttttg  ttacgattt  tgacagttt  240
tgttacttc  atttgaatt  ctatatttc  aatgtgggt  tatatgttt  atattaaga  300
gaagtaaag  aagttaaaa  ttagggagt  attttgttt  aatcaggag  tggccactt  360
cnggacagn  cacccaaca  gcaccaacg  acacgacac  acgagaacg  cngngcgcc  420
gagaagncc  gagacngcg  cgcnnc  446



<210> 7126
<211> 255
<212> PRT
<213> Homo sapiens
<308> NP_006752
<400> 7126

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
  1               5                  10                  15
Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
             20                  25                  30
Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
         35                  40                  45
Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
     50                  55                  60
Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
 65                  70                  75                  80
Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                 85                  90                  95
Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
             100                105                110
Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
         115                120                125
His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
     130                135                140
Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
 145                150                155                160
Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                 165                170                175
Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
             180                185                190
Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
         195                200                205
Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
     210                215                220
Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
 225                230                235                240
Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                 245                250                255



<210> 7127
<211> 646
<212> DNA
<213> Rattus norvegicus
<308> AI180442
<400> 7127

gttgaacaa  aatttattg  gacccctcc  tcgcagcct  tacaattcg  ggttacttt  60
tccgcttgt  gatcttgtt  gctagttcc  ggaagatgg  tgggggcag  ggcgcggag  120
actgctcta  gagactctt  aggcggttg  aactgtctt  ctcgtactt  aagaacaca  180
tccgcagat  cagctcctc  tacagtgct  tcacccgcg  cactttttc  gggtccttc  240
gcccataat  ctcctctaa  atctggcgc  gctgaggag  ggctcgtag  agacactga  300
ccaccagcc  gctgcattt  ttgtcctgg  tgtcagtgc  gacctttcc  gtcacactg  360
ggtctccaa  gagatcaag  tagtcgtcc  ggatctgga  gaactcgcc  atctccagc  420
ggatcttca  ggcattagc  tgttccttc  ccccatcaa  tccagccat  tacatggca  480
ccgcgatag  caggtagaa  gagtagaaa  ctgtcttgt  cttgacgat  gatttgtac  540
tcttttcag  gtatctacc  agatccact  ggccctggg  tgctgtgat  aggtcgaga  600
tctgcccga  ctcagtctg  taggaactc  gtagaaaga  ctccag  646



<210> 7128
<211> 353
<212> PRT
<213> Rattus norvegicus
<308> P05369
<400> 7128

Met Asn Gly Asp Gln Lys Leu Asp Val His Asn Gln Glu Lys Gln Asn 
  1               5                  10                  15
Phe Ile Gln His Phe Ser Gln Ile Val Lys Val Leu Thr Glu Asp Glu 
             20                  25                  30
Leu Gly His Pro Glu Lys Gly Asp Ala Ile Thr Arg Ile Lys Glu Val 
         35                  40                  45
Leu Glu Tyr Asn Thr Val Gly Gly Lys Tyr Asn Arg Gly Leu Thr Val 
     50                  55                  60
Val Gln Thr Phe Gln Glu Leu Val Glu Pro Arg Lys Gln Asp Ala Glu 
 65                  70                  75                  80
Ser Leu Gln Arg Ala Leu Thr Val Gly Trp Cys Val Glu Leu Leu Gln 
                 85                  90                  95
Ala Phe Phe Leu Val Leu Asp Asp Ile Met Asp Ser Ser Tyr Thr Arg 
             100                105                110
Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Ile Gly Leu Asp Ala 
         115                120                125
Ile Asn Asp Ala Leu Leu Leu Glu Ala Ala Ile Tyr Arg Leu Leu Lys 
     130                135                140
Phe Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Leu Glu Leu Phe 
 145                150                155                160
Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp Leu Ile 
                 165                170                175
Thr Ala Pro Gln Gly Gln Val Asp Leu Gly Arg Tyr Thr Glu Lys Arg 
             180                185                190
Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe Tyr Leu 
         195                200                205
Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu Lys Glu 
     210                215                220
His Ala Asn Ala Leu Lys Ile Leu Leu Glu Met Gly Glu Phe Phe Gln 
 225                230                235                240
Ile Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val Thr Gly 
                 245                250                255
Lys Val Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val Val 
             260                265                270
Gln Cys Leu Leu Arg Ala Thr Pro Gln Gln Arg Gln Ile Leu Glu Glu 
         275                280                285
Asn Tyr Gly Gln Lys Asp Pro Glu Lys Val Ala Arg Val Lys Ala Leu 
     290                295                300
Tyr Glu Glu Leu Asp Leu Arg Ser Val Phe Phe Lys Tyr Glu Glu Asp 
 305                310                315                320
Ser Tyr Asn Arg Leu Lys Ser Leu Ile Glu Gln Cys Ser Ala Pro Leu 
                 325                330                335
Pro Pro Ser Ile Phe Leu Glu Leu Ala Asn Lys Ile Tyr Lys Arg Arg 
             340                345                350
Lys 
         355



<210> 7129
<211> 1148
<212> DNA
<213> Homo sapiens
<308> J05262
<400> 7129

cacagaatg  acggagacc  gaattcaga  gtttatgcc  aagaaaagc  ggatttcgt  60
cagcacttc  cccagatcg  tagggtgct  actgaggat  agatggggc  cccagagat  120
ggagatgct  ttgcccggc  caaggaggt  ctggagtac  atgccattg  aggcaagta  180
aaccggggt  tgacggtgg  agtagcatt  cgggagctg  tggagccaa  gaaacagga  240
gctgatagt  tccagcggg  ctggactgt  ggctggtgt  tggaactgc  gcaagcttt  300
ttcctggtg  cagatgaca  catggattc  tcccttacc  gccggggac  gacctgctg  360
tatcagaag  cgggcgtgg  tttggatgc  atcaatgat  ctaacctcc  ggaagcatg  420
atctaccgc  tgctgaagc  ctattgccg  gagcagccc  attacctga  cctgatcga  480
ctcttcctg  agagttcct  tcagactga  attgggcag  ccctggacc  cctcacagc  540
ccccagggc  atgtggatc  tgtcagatt  actgaaaag  ggtacaaat  tattgtcaa  600
tacaagaca  ctttctact  cttctacct  cctatagct  cagccatgt  catggcagg  660
attgatggc  agaaggagc  cgccaatgc  aagaagatc  tgctggaga  gggggagtt  720
tttcagatt  aggatgatt  ccttgacct  tttggggac  ccagtgtga  cggcaaaat  780
ggcactgac  tccaggaca  caaatgcag  tggctggtg  ttcagtgtc  gcaacgggc  840
actccagaa  agtaccaga  cctgaagga  aattacggg  agaaggagg  tgagaaagt  900
gcccgggtg  aggcgctat  tgaggagct  gatctgcca  cagtgttct  gcaatatga  960
gaagacagt  acagccaca  tatggctct  attgaacag  acgcagcac  cctgccccc  1020
gccgtcttt  tggggcttg  gcgcaaaat  tacaagcgg  gaaagtgac  tagagattg  1080
aagggcggg  agaggaggc  ctcaataaa  aatcgtgta  ccttaaaaa  aaaaaaaac  1140
tcgacgat  1148



<210> 7130
<211> 353
<212> PRT
<213> Homo sapiens
<308> P14324
<400> 7130

Met Asn Gly Asp Gln Asn Ser Asp Val Tyr Ala Gln Glu Lys Gln Asp 
  1               5                  10                  15
Phe Val Gln His Phe Ser Gln Ile Val Arg Val Leu Thr Glu Asp Glu 
             20                  25                  30
Met Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys Glu Val 
         35                  40                  45
Leu Glu Tyr Asn Ala Ile Gly Gly Lys Tyr Asn Arg Gly Leu Thr Val 
     50                  55                  60
Val Val Ala Phe Arg Glu Leu Val Glu Pro Arg Lys Gln Asp Ala Asp 
 65                  70                  75                  80
Ser Leu Gln Arg Ala Trp Thr Val Gly Trp Cys Val Glu Leu Leu Gln 
                 85                  90                  95
Ala Phe Phe Leu Val Ala Asp Asp Ile Met Asp Ser Ser Leu Thr Arg 
             100                105                110
Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Val Gly Leu Asp Ala 
         115                120                125
Ile Asn Asp Ala Asn Leu Leu Glu Ala Cys Ile Tyr Arg Leu Leu Lys 
     130                135                140
Leu Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Ile Glu Leu Phe 
 145                150                155                160
Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp Leu Leu 
                 165                170                175
Thr Ala Pro Gln Gly Asn Val Asp Leu Val Arg Phe Thr Glu Lys Arg 
             180                185                190
Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe Tyr Leu 
         195                200                205
Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu Lys Glu 
     210                215                220
His Ala Asn Ala Lys Lys Ile Leu Leu Glu Met Gly Glu Phe Phe Gln 
 225                230                235                240
Ile Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val Thr Gly 
                 245                250                255
Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val Val 
             260                265                270
Gln Cys Leu Gln Arg Ala Thr Pro Glu Gln Tyr Gln Ile Leu Lys Glu 
         275                280                285
Asn Tyr Gly Gln Lys Glu Ala Glu Lys Val Ala Arg Val Lys Ala Leu 
     290                295                300
Tyr Glu Glu Leu Asp Leu Pro Ala Val Phe Leu Gln Tyr Glu Glu Asp 
 305                310                315                320
Ser Tyr Ser His Ile Met Ala Leu Ile Glu Gln Tyr Ala Ala Pro Leu 
                 325                330                335
Pro Pro Ala Val Phe Leu Gly Leu Ala Arg Lys Ile Tyr Lys Arg Arg 
             340                345                350
Lys 
         355



<210> 7131
<211> 646
<212> DNA
<213> Rattus norvegicus
<308> AI180442
<400> 7131

gttgaacaa  aatttattg  gacccctcc  tcgcagcct  tacaattcg  ggttacttt  60
tccgcttgt  gatcttgtt  gctagttcc  ggaagatgg  tgggggcag  ggcgcggag  120
actgctcta  gagactctt  aggcggttg  aactgtctt  ctcgtactt  aagaacaca  180
tccgcagat  cagctcctc  tacagtgct  tcacccgcg  cactttttc  gggtccttc  240
gcccataat  ctcctctaa  atctggcgc  gctgaggag  ggctcgtag  agacactga  300
ccaccagcc  gctgcattt  ttgtcctgg  tgtcagtgc  gacctttcc  gtcacactg  360
ggtctccaa  gagatcaag  tagtcgtcc  ggatctgga  gaactcgcc  atctccagc  420
ggatcttca  ggcattagc  tgttccttc  ccccatcaa  tccagccat  tacatggca  480
ccgcgatag  caggtagaa  gagtagaaa  ctgtcttgt  cttgacgat  gatttgtac  540
tcttttcag  gtatctacc  agatccact  ggccctggg  tgctgtgat  aggtcgaga  600
tctgcccga  ctcagtctg  taggaactc  gtagaaaga  ctccag  646



<210> 7132
<211> 353
<212> PRT
<213> Rattus norvegicus
<308> P05369
<400> 7132

Met Asn Gly Asp Gln Lys Leu Asp Val His Asn Gln Glu Lys Gln Asn 
  1               5                  10                  15
Phe Ile Gln His Phe Ser Gln Ile Val Lys Val Leu Thr Glu Asp Glu 
             20                  25                  30
Leu Gly His Pro Glu Lys Gly Asp Ala Ile Thr Arg Ile Lys Glu Val 
         35                  40                  45
Leu Glu Tyr Asn Thr Val Gly Gly Lys Tyr Asn Arg Gly Leu Thr Val 
     50                  55                  60
Val Gln Thr Phe Gln Glu Leu Val Glu Pro Arg Lys Gln Asp Ala Glu 
 65                  70                  75                  80
Ser Leu Gln Arg Ala Leu Thr Val Gly Trp Cys Val Glu Leu Leu Gln 
                 85                  90                  95
Ala Phe Phe Leu Val Leu Asp Asp Ile Met Asp Ser Ser Tyr Thr Arg 
             100                105                110
Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Ile Gly Leu Asp Ala 
         115                120                125
Ile Asn Asp Ala Leu Leu Leu Glu Ala Ala Ile Tyr Arg Leu Leu Lys 
     130                135                140
Phe Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Leu Glu Leu Phe 
 145                150                155                160
Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp Leu Ile 
                 165                170                175
Thr Ala Pro Gln Gly Gln Val Asp Leu Gly Arg Tyr Thr Glu Lys Arg 
             180                185                190
Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe Tyr Leu 
         195                200                205
Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu Lys Glu 
     210                215                220
His Ala Asn Ala Leu Lys Ile Leu Leu Glu Met Gly Glu Phe Phe Gln 
 225                230                235                240
Ile Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val Thr Gly 
                 245                250                255
Lys Val Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val Val 
             260                265                270
Gln Cys Leu Leu Arg Ala Thr Pro Gln Gln Arg Gln Ile Leu Glu Glu 
         275                280                285
Asn Tyr Gly Gln Lys Asp Pro Glu Lys Val Ala Arg Val Lys Ala Leu 
     290                295                300
Tyr Glu Glu Leu Asp Leu Arg Ser Val Phe Phe Lys Tyr Glu Glu Asp 
 305                310                315                320
Ser Tyr Asn Arg Leu Lys Ser Leu Ile Glu Gln Cys Ser Ala Pro Leu 
                 325                330                335
Pro Pro Ser Ile Phe Leu Glu Leu Ala Asn Lys Ile Tyr Lys Arg Arg 
             340                345                350
Lys 
         355



<210> 7133
<211> 1148
<212> DNA
<213> Homo sapiens
<308> J05262
<400> 7133

cacagaatg  acggagacc  gaattcaga  gtttatgcc  aagaaaagc  ggatttcgt  60
cagcacttc  cccagatcg  tagggtgct  actgaggat  agatggggc  cccagagat  120
ggagatgct  ttgcccggc  caaggaggt  ctggagtac  atgccattg  aggcaagta  180
aaccggggt  tgacggtgg  agtagcatt  cgggagctg  tggagccaa  gaaacagga  240
gctgatagt  tccagcggg  ctggactgt  ggctggtgt  tggaactgc  gcaagcttt  300
ttcctggtg  cagatgaca  catggattc  tcccttacc  gccggggac  gacctgctg  360
tatcagaag  cgggcgtgg  tttggatgc  atcaatgat  ctaacctcc  ggaagcatg  420
atctaccgc  tgctgaagc  ctattgccg  gagcagccc  attacctga  cctgatcga  480
ctcttcctg  agagttcct  tcagactga  attgggcag  ccctggacc  cctcacagc  540
ccccagggc  atgtggatc  tgtcagatt  actgaaaag  ggtacaaat  tattgtcaa  600
tacaagaca  ctttctact  cttctacct  cctatagct  cagccatgt  catggcagg  660
attgatggc  agaaggagc  cgccaatgc  aagaagatc  tgctggaga  gggggagtt  720
tttcagatt  aggatgatt  ccttgacct  tttggggac  ccagtgtga  cggcaaaat  780
ggcactgac  tccaggaca  caaatgcag  tggctggtg  ttcagtgtc  gcaacgggc  840
actccagaa  agtaccaga  cctgaagga  aattacggg  agaaggagg  tgagaaagt  900
gcccgggtg  aggcgctat  tgaggagct  gatctgcca  cagtgttct  gcaatatga  960
gaagacagt  acagccaca  tatggctct  attgaacag  acgcagcac  cctgccccc  1020
gccgtcttt  tggggcttg  gcgcaaaat  tacaagcgg  gaaagtgac  tagagattg  1080
aagggcggg  agaggaggc  ctcaataaa  aatcgtgta  ccttaaaaa  aaaaaaaac  1140
tcgacgat  1148



<210> 7134
<211> 353
<212> PRT
<213> Homo sapiens
<308> P14324
<400> 7134

Met Asn Gly Asp Gln Asn Ser Asp Val Tyr Ala Gln Glu Lys Gln Asp 
  1               5                  10                  15
Phe Val Gln His Phe Ser Gln Ile Val Arg Val Leu Thr Glu Asp Glu 
             20                  25                  30
Met Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys Glu Val 
         35                  40                  45
Leu Glu Tyr Asn Ala Ile Gly Gly Lys Tyr Asn Arg Gly Leu Thr Val 
     50                  55                  60
Val Val Ala Phe Arg Glu Leu Val Glu Pro Arg Lys Gln Asp Ala Asp 
 65                  70                  75                  80
Ser Leu Gln Arg Ala Trp Thr Val Gly Trp Cys Val Glu Leu Leu Gln 
                 85                  90                  95
Ala Phe Phe Leu Val Ala Asp Asp Ile Met Asp Ser Ser Leu Thr Arg 
             100                105                110
Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Val Gly Leu Asp Ala 
         115                120                125
Ile Asn Asp Ala Asn Leu Leu Glu Ala Cys Ile Tyr Arg Leu Leu Lys 
     130                135                140
Leu Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Ile Glu Leu Phe 
 145                150                155                160
Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp Leu Leu 
                 165                170                175
Thr Ala Pro Gln Gly Asn Val Asp Leu Val Arg Phe Thr Glu Lys Arg 
             180                185                190
Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe Tyr Leu 
         195                200                205
Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu Lys Glu 
     210                215                220
His Ala Asn Ala Lys Lys Ile Leu Leu Glu Met Gly Glu Phe Phe Gln 
 225                230                235                240
Ile Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val Thr Gly 
                 245                250                255
Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val Val 
             260                265                270
Gln Cys Leu Gln Arg Ala Thr Pro Glu Gln Tyr Gln Ile Leu Lys Glu 
         275                280                285
Asn Tyr Gly Gln Lys Glu Ala Glu Lys Val Ala Arg Val Lys Ala Leu 
     290                295                300
Tyr Glu Glu Leu Asp Leu Pro Ala Val Phe Leu Gln Tyr Glu Glu Asp 
 305                310                315                320
Ser Tyr Ser His Ile Met Ala Leu Ile Glu Gln Tyr Ala Ala Pro Leu 
                 325                330                335
Pro Pro Ala Val Phe Leu Gly Leu Ala Arg Lys Ile Tyr Lys Arg Arg 
             340                345                350
Lys 
         355



<210> 7135
<211> 499
<212> DNA
<213> Rattus norvegicus
<308> AI227715
<400> 7135

aaaaggcaa  ttactgtat  tttatggca  gaagaagaa  aagtgttca  acggtttct  60
acgaagtca  gtatttaaa  ggtgaatga  gatgtgtta  tggagatga  atgaaccaa  120
aaatgattg  ttgtcattt  tgcaggaaa  taatgctcc  tttcaatat  actaaacag  180
gactaattt  taagtgctt  attgaaaaa  acacatatt  tcatataaa  ttacagtag  240
ggtacgaag  ggtttctac  tactttgca  agcactctg  tggccagtg  caggctgta  300
gttgtcagc  gggtctttg  agcggtatg  agtcaccta  taactttgt  tacagtgat  360
caatttaaa  tgaattttc  ccttaggat  attaatcca  cttaaaaaa  tacttgata  420
taatgatta  taaagatat  tgtagataa  caatagcta  taaatcttc  aatttgtgt  480
aatggtacc  tgtactaat  499



<210> 7136
<211> 1135
<212> PRT
<213> Rattus norvegicus
<308> O55081
<400> 7136

Met Ala Ser Gly Gly Asn Gln Ser Ser Pro Pro Pro Pro Ala Ala Ala 
  1               5                  10                  15
Ala Ser Ser Glu Glu Glu Glu Glu Asp Gly Asp Thr Ala Asp Arg Ala 
             20                  25                  30
Gln Pro Ala Gly Ser Pro Ser His Gln Ile Gln Gln Arg Phe Glu Glu 
         35                  40                  45
Leu Cys Ser Arg Leu Asn Met Asp Glu Ala Ala Arg Ala Glu Ala Trp 
     50                  55                  60
Ser Ser Tyr Arg Ser Met Ser Glu Ser Tyr Thr Leu Glu Gly Asn Asp 
 65                  70                  75                  80
Leu His Trp Leu Ala Cys Ala Leu Tyr Val Ala Cys Arg Lys Ser Val 
                 85                  90                  95
Pro Thr Val Ser Lys Gly Thr Ala Glu Gly Asn Tyr Val Ser Leu Thr 
             100                105                110
Arg Ile Leu Arg Cys Ser Glu Gln Ser Leu Ile Glu Phe Phe Asn Lys 
         115                120                125
Met Lys Lys Trp Glu Asp Met Ala Asn Leu Pro Pro His Phe Arg Glu 
     130                135                140
Arg Thr Glu Arg Leu Glu Arg Asn Phe Thr Val Ser Ala Val Ile Phe 
 145                150                155                160
Lys Lys Tyr Glu Pro Ile Phe Gln Asp Ile Phe Lys Tyr Pro Gln Glu 
                 165                170                175
Glu Gln Pro Arg Gln Gln Arg Gly Arg Lys Gln Arg Arg Gln Pro Cys 
             180                185                190
Thr Thr Ser Glu Ile Phe His Phe Cys Trp Val Leu Phe Ile Tyr Ala 
         195                200                205
Lys Gly Asn Phe Pro Met Ile Ser Asp Asp Leu Val Asn Ser Tyr His 
     210                215                220
Leu Leu Leu Cys Ala Leu Asp Leu Val Tyr Gly Asn Ala Leu Gln Cys 
 225                230                235                240
Ser Asn Arg Lys Glu Leu Val Asn Pro Asn Phe Lys Gly Val Ser Glu 
                 245                250                255
Asp Gly His Pro Arg Asp Ser His Pro Ser Ser Asp Pro Pro Cys Val 
             260                265                270
Ile Glu Lys Leu Cys Ser Leu His Asp Gly Leu Val Leu Glu Ala Lys 
         275                280                285
Gly Ile Lys Gln His Phe Trp Lys Pro Tyr Ile Arg Lys Leu Phe Glu 
     290                295                300
Lys Lys Leu Leu Arg Gly Lys Glu Glu Asn Leu Thr Gly Phe Leu Glu 
 305                310                315                320
Pro Gly Asn Phe Ala Glu Ser Phe Lys Ala Val Asn Lys Ala Tyr Glu 
                 325                330                335
Glu Tyr Val Leu Ala Thr Gly Ser Leu Asp Glu Arg Ile Phe Leu Gly 
             340                345                350
Glu Asp Ala Glu Glu Glu Val Gly Thr Phe Ser Arg Cys Val Ser Ala 
         355                360                365
Ala Ser Gly Thr Glu Ser Ala Glu Arg Thr Gln Met Arg Asp Ile Leu 
     370                375                380
Gln Gln His Leu Asp Lys Ser Lys Thr Leu Arg Val Cys Asn Pro Leu 
 385                390                395                400
Thr Gly Val Arg Tyr Val Gln Glu Asn Ser Pro Cys Val Thr Pro Val 
                 405                410                415
Ser Thr Ala Thr His Ser Leu Asn Arg Leu His Thr Met Leu Ala Gly 
             420                425                430
Leu Arg Asn Ala Pro Ser Glu Lys Leu Glu Gln Ile Leu Arg Ser Cys 
         435                440                445
Ser Arg Asp Pro Thr Arg Ala Ile Ala Asp Arg Leu Arg Glu Met Tyr 
     450                455                460
Glu Ile Tyr Ser Gln His Phe Gln Pro Asp Glu Asn Val Ser Asn Cys 
 465                470                475                480
Ala Lys Glu Met Ala Asn Lys His Phe Arg Phe Ala Glu Met Leu Tyr 
                 485                490                495
Tyr Lys Val Leu Glu Ser Val Ile Glu Gln Glu Gln Lys Arg Leu Gly 
             500                505                510
Asp Met Asp Leu Ser Gly Val Leu Glu Gln Asp Ala Phe His Lys Ser 
         515                520                525
Leu Leu Ala Cys Cys Leu Glu Val Val Ala Phe Ser Tyr Lys Pro Pro 
     530                535                540
Gly Asn Phe Pro Phe Ile Ala Glu Ile Phe Asp Val Pro His Tyr His 
 545                550                555                560
Phe Tyr Lys Val Ile Glu Val Phe Ile Arg Ala Glu Asp Gly Leu Cys 
                 565                570                575
Arg Glu Val Val Lys His Leu Asn Gln Ile Glu Glu Gln Ile Leu Asp 
             580                585                590
His Leu Ala Trp Lys Thr Lys Ser Pro Leu Trp Asp Arg Ile Arg Asp 
         595                600                605
Asn Glu Asn Arg Val Pro Thr Cys Glu Glu Val Thr Pro Pro His Asn 
     610                615                620
Leu Glu Arg Thr Asp Glu Ile Tyr Ile Ala Gly Ser Pro Leu Thr Pro 
 625                630                635                640
Arg Arg Val Gly Glu Val Arg Thr Asp Ala Gly Gly Leu Gly Arg Ser 
                 645                650                655
Val Thr Ser Pro Thr Thr Leu Tyr Asp Arg Tyr Ser Ser Pro Thr Val 
             660                665                670
Ser Thr Thr Arg Arg Arg Leu Phe Glu Ser Asp Ser Pro Ser Glu Gly 
         675                680                685
Ser Thr Ala Gly Arg Ile Pro Pro Gln Pro Leu Val Asn Ala Val Pro 
     690                695                700
Val Gln Asn Val Ser Gly Glu Thr Val Ser Val Thr Pro Val Pro Gly 
 705                710                715                720
Gln Thr Leu Val Thr Met Ala Thr Ala Thr Val Thr Ala Asn Asn Gly 
                 725                730                735
Gln Thr Val Thr Ile Pro Val Gln Gly Ile Ala Asn Glu Asn Gly Gly 
             740                745                750
Ile Thr Phe Phe Pro Val Gln Val Asn Val Gly Gly Gln Ala Gln Ala 
         755                760                765
Val Thr Gly Ser Ile Gln Pro Leu Ser Ala Gln Ala Leu Ala Gly Ser 
     770                775                780
Leu Ser Ser Gln Gln Val Thr Gly Thr Thr Leu Gln Val Pro Gly Pro 
 785                790                795                800
Val Ala Ile Gln Gln Ile Ser Pro Gly Gly Gln Gln Gln Asn Gln Gly 
                 805                810                815
Gln Pro Leu Thr Ser Ser Ser Ile Arg Pro Arg Lys Thr Ser Ser Leu 
             820                825                830
Ser Leu Phe Phe Arg Lys Val Tyr Tyr Leu Ala Gly Val Arg Leu Arg 
         835                840                845
Asp Leu Cys Thr Lys Leu Asp Ile Ser Asp Glu Leu Arg Lys Lys Ile 
     850                855                860
Trp Thr Cys Phe Glu Phe Ser Ile Val Gln Cys Pro Glu Leu Met Met 
 865                870                875                880
Asp Arg His Leu Asp Gln Leu Leu Met Cys Ala Ile Tyr Val Met Ala 
                 885                890                895
Lys Val Thr Lys Glu Asp Lys Ser Phe Gln Asn Ile Met Arg Cys Tyr 
             900                905                910
Arg Thr Gln Pro Gln Ala Arg Ser Gln Val Tyr Arg Ser Val Leu Ile 
         915                920                925
Lys Gly Lys Arg Arg Asn Ser Gly Ser Cys Glu Asn Arg Ser His Gln 
     930                935                940
Asn Ser Pro Thr Glu Leu Asn Thr Asp Arg Ala Ser Arg Asp Ser Ser 
 945                950                955                960
Pro Val Met Arg Ser Asn Ser Thr Leu Pro Val Pro Gln Pro Ser Ser 
                 965                970                975
Ala Pro Pro Thr Pro Thr Arg Leu Thr Gly Ala Asn Ser Asp Ile Glu 
             980                985                990
Glu Glu Glu Arg Gly Asp Leu Ile Gln Phe Tyr Asn Asn Ile Tyr Arg 
         995                1000                1005
Lys Gln Ile Gln Thr Phe Ala Met Lys Tyr Ser Gln Ala Asn Ser Gln 
     1010                1015                1020
Met Asp Thr Pro Pro Leu Ser Pro Tyr Pro Phe Val Arg Thr Gly Ser 
 1025                1030                1035                1040
Pro Arg Arg Val Gln Leu Ser Gln Ser His Pro Ile Tyr Ile Ser Pro 
                 1045                1050                1055
His Lys Asn Glu Ala Met Leu Ser Pro Arg Glu Lys Ile Phe Tyr Tyr 
             1060                1065                1070
Phe Ser Asn Ser Pro Ser Lys Arg Leu Arg Glu Ile Asn Ser Met Ile 
         1075                1080                1085
Arg Thr Gly Glu Thr Pro Thr Lys Lys Arg Gly Ile Leu Leu Asp Asp 
     1090                1095                1100
Gly Ser Glu Ser Pro Ala Lys Arg Ile Cys Pro Glu Asn His Ser Ala 
 1105                1110                1115                1120
Leu Leu Arg Arg Leu Gln Asp Val Ala Asn Asp Arg Gly Ser His 
                 1125                1130                1135



<210> 7137
<211> 1763
<212> DNA
<213> Homo sapiens
<308> AK023320
<400> 7137

atcaagcag  ggcagggct  gcgctgcgg  gggagatgc  gtcgggccg  ggcggcgct  60
ggcagccag  agctctgca  tgaaggcac  ggggtaaag  gaatgccga  gacagaaga  120
ttggatgat  caccactga  tttctttgt  tggaataca  gttatgaac  ctttctgga  180
catgtctac  agctctgta  gcaaacgat  tgaaggtga  gagaagaca  taacagggg  240
cgtgaaaac  agtcctcca  gaactgcac  aaagaaaca  ctgccttct  ttcccaaaa  300
tgctttgcc  ataactaag  ctacatctc  tgccccagc  gcacagtca  caaatggca  360
gcatgcgtc  tatggaccc  tctacctgg  atactctct  cttgcagaa  ttaccttgg  420
tgtgaagca  aagctacca  gcgtctatg  gcagccatc  tatcgctct  cattaatgt  480
gtttggagt  atattcata  ggcatggac  ttaccaaga  ggcgtattt  agtttacag  540
ttacatccc  gataactat  cagatggtg  ctgtccacg  ttggtgttc  atattcctg  600
ctttcaccc  ctagttgat  ccacctcag  tgagctgga  gtgaagaga  catttgcaa  660
atggaggcg  aaccataat  atatttggc  ggtattaat  tatgcaagg  gagttttct  720
caagattga  acagcaagc  ccctgaacc  agaggctgc  gtactgtat  aaaaagata  780
tcagctttt  aaaagtaaa  ttgttgaca  tgttaaggt  tgcactgct  gtttgtttg  840
ccaacctaa  atagaagac  cctatgcaa  tagcttttc  ccatggaat  cttctgtac  900
tgatgaagc  agagaaaag  tgctgactc  gaaaaagcc  gaagaacag  acaataaaa  960
tgttcatgt  gctggcctg  catgggtaa  gcctggctc  gtacagcct  tcagtaaag  1020
agagaaaac  gtggcgact  aagagatgg  gaatctggt  caccatgca  tttcctgct  1080
gactctggc  tagttcaag  tgaccaatg  cagaggact  cctgaagag  aaaactgtg  1140
gaacaatga  tgactgcca  tgttttcca  gtatgcata  gttctaaca  cagggtttg  1200
aaacctgtc  ctaagtaat  cattacttc  gtcagaagt  tcttagggt  gttatctag  1260
tcagtactc  aaattattg  ggaccttga  gcttaagta  gtatttttc  gaatataat  1320
ctaaaggta  gttgcattc  tttaaacta  tagagcaga  agaattcag  actacttaa  1380
agtttataa  tcagtggtt  cagttgtat  tatgttagg  aatggagag  tatagagag  1440
gcaggttcc  tagctcagc  cttttaagt  gaagatcat  tgaatctca  tcttcagcc  1500
gcactgatt  gtagcctgc  ctgtcttac  gatttacaa  ctgaaatca  tgagaaatg  1560
ctttagttc  gtgagaaga  accagaaca  ttgttccta  tgttgtgtt  tttttttta  1620
gcaaattac  tactgtatt  ttatggcag  agggagaaa  agtgttaca  cggcttcta  1680
tgaagtccg  tatttaaat  ataaatgac  aatgtgttt  gtagagaca  aataaacca  1740
taaatgatt  ttctttgcc  ttt  1763



<210> 7138
<211> 1139
<212> PRT
<213> Homo sapiens
<308> CAA53661
<400> 7138

Met Pro Ser Gly Gly Asp Gln Ser Pro Pro Pro Pro Pro Pro Pro Pro 
  1               5                  10                  15
Ala Ala Ala Ala Ser Asp Glu Glu Glu Glu Asp Asp Gly Glu Ala Glu 
             20                  25                  30
Asp Ala Ala Pro Ser Ala Glu Ser Pro Thr Pro Gln Ile Gln Gln Arg 
         35                  40                  45
Phe Asp Glu Leu Cys Ser Arg Leu Asn Met Asp Glu Ala Ala Arg Ala 
     50                  55                  60
Glu Ala Trp Asp Ser Tyr Arg Ser Met Ser Glu Ser Tyr Thr Leu Glu 
 65                  70                  75                  80
Gly Asn Asp Leu His Trp Leu Ala Cys Ala Leu Tyr Val Ala Cys Arg 
                 85                  90                  95
Lys Ser Val Pro Thr Val Ser Lys Gly Thr Val Glu Gly Asn Tyr Val 
             100                105                110
Ser Leu Thr Arg Ile Leu Lys Cys Ser Glu Gln Ser Leu Ile Glu Phe 
         115                120                125
Phe Asn Lys Met Lys Lys Trp Glu Asp Met Ala Asn Leu Pro Pro His 
     130                135                140
Phe Arg Glu Arg Thr Glu Arg Leu Glu Arg Asn Phe Thr Val Ser Ala 
 145                150                155                160
Val Ile Phe Lys Lys Tyr Glu Pro Ile Phe Gln Asp Ile Phe Lys Tyr 
                 165                170                175
Pro Gln Glu Glu Gln Pro Arg Gln Gln Arg Gly Arg Lys Gln Arg Arg 
             180                185                190
Gln Pro Cys Thr Val Ser Glu Ile Phe His Phe Cys Trp Val Leu Phe 
         195                200                205
Ile Tyr Ala Lys Gly Asn Phe Pro Met Ile Ser Asp Asp Leu Val Asn 
     210                215                220
Ser Tyr His Leu Leu Leu Cys Ala Leu Asp Leu Val Tyr Gly Asn Ala 
 225                230                235                240
Leu Gln Cys Ser Asn Arg Lys Glu Leu Val Asn Pro Asn Phe Lys Gly 
                 245                250                255
Leu Ser Glu Asp Phe His Ala Lys Asp Ser Lys Pro Ser Ser Asp Pro 
             260                265                270
Pro Cys Ile Ile Glu Lys Leu Cys Ser Leu His Asp Gly Leu Val Leu 
         275                280                285
Glu Ala Lys Gly Ile Lys Glu His Phe Trp Lys Pro Tyr Ile Arg Lys 
     290                295                300
Leu Tyr Glu Lys Lys Leu Leu Lys Gly Lys Glu Glu Asn Leu Thr Gly 
 305                310                315                320
Phe Leu Glu Pro Gly Asn Phe Gly Glu Ser Phe Lys Ala Ile Asn Lys 
                 325                330                335
Ala Tyr Glu Glu Tyr Val Leu Ser Val Gly Asn Leu Asp Glu Arg Ile 
             340                345                350
Phe Leu Gly Glu Asp Ala Glu Glu Glu Ile Gly Thr Leu Ser Arg Cys 
         355                360                365
Leu Asn Ala Gly Ser Gly Thr Glu Thr Ala Glu Arg Val Gln Met Lys 
     370                375                380
Asn Ile Leu Gln Gln His Phe Asp Lys Ser Lys Ala Leu Arg Ile Ser 
 385                390                395                400
Thr Pro Leu Thr Gly Val Arg Tyr Ile Lys Glu Asn Ser Pro Cys Val 
                 405                410                415
Thr Pro Val Ser Thr Ala Thr His Ser Leu Ser Arg Leu His Thr Met 
             420                425                430
Leu Thr Gly Leu Arg Asn Ala Pro Ser Glu Lys Leu Glu Gln Ile Leu 
         435                440                445
Arg Thr Cys Ser Arg Asp Pro Thr Gln Ala Ile Ala Asn Arg Leu Lys 
     450                455                460
Glu Met Phe Glu Ile Tyr Ser Gln His Phe Gln Pro Asp Glu Asp Phe 
 465                470                475                480
Ser Asn Cys Ala Lys Glu Ile Ala Ser Lys His Phe Arg Phe Ala Glu 
                 485                490                495
Met Leu Tyr Tyr Lys Val Leu Glu Ser Val Ile Glu Gln Glu Gln Lys 
             500                505                510
Arg Leu Gly Asp Met Asp Leu Ser Gly Ile Leu Glu Gln Asp Ala Phe 
         515                520                525
His Arg Ser Leu Leu Ala Cys Cys Leu Glu Val Val Thr Phe Ser Tyr 
     530                535                540
Lys Pro Pro Gly Asn Phe Pro Phe Ile Thr Glu Ile Phe Asp Val Pro 
 545                550                555                560
Leu Tyr His Phe Tyr Lys Val Ile Glu Val Phe Ile Arg Ala Glu Asp 
                 565                570                575
Gly Leu Cys Arg Glu Val Val Lys His Leu Asn Gln Ile Glu Glu Gln 
             580                585                590
Ile Leu Asp His Leu Ala Trp Lys Pro Glu Ser Pro Leu Trp Glu Lys 
         595                600                605
Ile Arg Asp Asn Glu Asn Arg Val Pro Thr Cys Glu Glu Val Met Pro 
     610                615                620
Pro Gln Asn Leu Glu Arg Ala Asp Glu Ile Cys Ile Ala Gly Ser Pro 
 625                630                635                640
Leu Thr Pro Arg Arg Val Thr Glu Val Arg Ala Asp Thr Gly Gly Leu 
                 645                650                655
Gly Arg Ser Ile Thr Ser Pro Thr Thr Leu Tyr Asp Arg Tyr Ser Ser 
             660                665                670
Pro Pro Ala Ser Thr Thr Arg Arg Arg Leu Phe Val Glu Asn Asp Ser 
         675                680                685
Pro Ser Asp Gly Gly Thr Pro Gly Arg Met Pro Pro Gln Pro Leu Val 
     690                695                700
Asn Ala Val Pro Val Gln Asn Val Ser Gly Glu Thr Val Ser Val Thr 
 705                710                715                720
Pro Val Pro Gly Gln Thr Leu Val Thr Met Ala Thr Ala Thr Val Thr 
                 725                730                735
Ala Asn Asn Gly Gln Thr Val Thr Ile Pro Val Gln Gly Ile Ala Asn 
             740                745                750
Glu Asn Gly Gly Ile Thr Phe Phe Pro Val Gln Val Asn Val Gly Gly 
         755                760                765
Gln Ala Gln Ala Val Thr Gly Ser Ile Gln Pro Leu Ser Ala Gln Ala 
     770                775                780
Leu Ala Gly Ser Leu Ser Ser Gln Gln Val Thr Gly Thr Thr Leu Gln 
 785                790                795                800
Val Pro Gly Gln Val Ala Ile Gln Gln Ile Ser Pro Gly Gly Gln Gln 
                 805                810                815
Gln Lys Gln Gly Gln Ser Val Thr Ser Ser Ser Asn Arg Pro Arg Lys 
             820                825                830
Thr Ser Ser Leu Ser Leu Phe Phe Arg Lys Val Tyr His Leu Ala Ala 
         835                840                845
Val Arg Leu Arg Asp Leu Cys Ala Lys Leu Asp Ile Ser Asp Glu Leu 
     850                855                860
Arg Lys Lys Ile Trp Thr Cys Phe Glu Phe Ser Ile Ile Gln Cys Pro 
 865                870                875                880
Glu Leu Met Met Asp Arg His Leu Asp Gln Leu Leu Met Cys Ala Ile 
                 885                890                895
Tyr Val Met Ala Lys Val Thr Lys Glu Asp Lys Ser Phe Gln Asn Ile 
             900                905                910
Met Arg Cys Tyr Arg Thr Gln Pro Gln Ala Arg Ser Gln Val Tyr Arg 
         915                920                925
Ser Val Leu Ile Lys Gly Lys Arg Lys Arg Arg Asn Ser Gly Ser Ser 
     930                935                940
Asp Ser Arg Ser His Gln Asn Ser Pro Thr Glu Leu Asn Lys Asp Arg 
 945                950                955                960
Thr Ser Arg Asp Ser Ser Pro Val Met Arg Ser Ser Ser Thr Leu Pro 
                 965                970                975
Val Pro Gln Pro Ser Ser Ala Pro Pro Thr Pro Thr Arg Leu Thr Gly 
             980                985                990
Ala Asn Ser Asp Met Glu Glu Glu Glu Arg Gly Asp Leu Ile Gln Phe 
         995                1000                1005
Tyr Asn Asn Ile Tyr Ile Lys Gln Ile Lys Thr Phe Ala Met Lys Tyr 
     1010                1015                1020
Ser Gln Ala Asn Met Asp Ala Pro Pro Leu Ser Pro Tyr Pro Phe Val 
 1025                1030                1035                1040
Arg Thr Gly Ser Pro Arg Arg Ile Gln Leu Ser Gln Asn His Pro Val 
                 1045                1050                1055
Tyr Ile Ser Pro His Lys Asn Glu Thr Met Leu Ser Pro Arg Glu Lys 
             1060                1065                1070
Ile Phe Tyr Tyr Phe Ser Asn Ser Pro Ser Lys Arg Leu Arg Glu Ile 
         1075                1080                1085
Asn Ser Met Ile Arg Thr Gly Glu Thr Pro Thr Lys Lys Arg Gly Ile 
     1090                1095                1100
Leu Leu Glu Asp Gly Ser Glu Ser Pro Ala Lys Arg Ile Cys Pro Glu 
 1105                1110                1115                1120
Asn His Ser Ala Leu Leu Arg Arg Leu Gln Asp Val Ala Asn Asp Arg 
                 1125                1130                1135
Gly Ser His 
             1140



<210> 7139
<211> 605
<212> DNA
<213> Rattus norvegicus
<308> AI227936
<400> 7139

ggccgctag  gtttttttt  ttttttttt  ttttttttt  gctgtcaaa  acacaaaga  60
catatttat  tgatacaga  tcacaagtg  gttggggtg  gctcatcat  ggcagtccc  120
gccggcgtg  gtgccagca  ttcaggaat  agggttacc  ggagtgagt  agagcaaac  180
caagagcta  cctgaagcc  ctggtcaca  ggaaggccg  gacgggata  gagggaggc  240
gtgacattc  ctctgttct  aactgccat  tcatcttct  cttgctgac  ttgaggtgg  300
ctgtgagct  tctctgctg  ggctgtgca  cccagaagc  aggacttcc  ctaggaaac  360
ttttgtgtt  tgtattgtt  ttcctccca  aacgatcct  actccagga  tggtacggt  420
gaggttata  actgtcagt  cctcttcat  ggtggctcc  ccaataacg  acacgatga  480
gtcctgagg  ctgtctctg  atgtgctgg  gcctaaata  ggatagagg  tttccttaa  540
cttcccttt  atgagatgg  ccaaggtct  atgccgaaa  ggctggtgc  gggtgtaca  600
atttt  605



<210> 7140
<211> 570
<212> PRT
<213> Rattus norvegicus
<308> AAB53041
<400> 7140

Met Asn Val Val Phe Ala Val Lys Gln Tyr Ile Ser Lys Met Ile Glu 
  1               5                  10                  15
Asp Ser Gly Pro Gly Met Lys Val Leu Leu Met Asp Lys Glu Thr Thr 
             20                  25                  30
Gly Ile Val Ser Met Val Tyr Thr Gln Ser Glu Ile Leu Gln Lys Glu 
         35                  40                  45
Val Tyr Leu Phe Glu Arg Ile Asp Ser Gln Asn Arg Glu Ile Met Lys 
     50                  55                  60
His Leu Lys Ala Ile Cys Phe Leu Arg Pro Thr Lys Glu Asn Val Asp 
 65                  70                  75                  80
Ser Leu Ile Gln Glu Leu Arg Arg Pro Lys Tyr Ser Ile Tyr Phe Ile 
                 85                  90                  95
Tyr Phe Ser Asn Val Ile Ser Lys Ser Asp Val Lys Ser Leu Ala Glu 
             100                105                110
Ala Asp Glu Gln Glu Val Val Ala Glu Val Gln Glu Phe Tyr Gly Asp 
         115                120                125
Tyr Ile Ala Val Asn Pro His Leu Phe Ser Leu Asn Ile Leu Gly Cys 
     130                135                140
Cys Gln Gly Arg Asn Trp Asp Pro Ala Gln Leu Ser Arg Thr Thr Gln 
 145                150                155                160
Gly Leu Thr Ala Leu Leu Leu Ser Leu Lys Lys Cys Pro Met Ile Arg 
                 165                170                175
Tyr Gln Leu Ser Ser Glu Ala Ala Lys Arg Leu Gly Glu Cys Val Lys 
             180                185                190
Gln Val Ile Ser Lys Glu Tyr Glu Leu Phe Glu Phe Arg Arg Thr Glu 
         195                200                205
Val Pro Pro Leu Leu Leu Ile Leu Asp Arg Cys Asp Asp Ala Ile Thr 
     210                215                220
Pro Leu Leu Asn Gln Trp Thr Tyr Gln Ala Met Val His Glu Leu Leu 
 225                230                235                240
Gly Ile Asn Asn Asn Arg Ile Asp Leu Ser Arg Val Pro Gly Ile Ser 
                 245                250                255
Lys Asp Leu Arg Glu Val Val Leu Ser Ala Glu Asn Asp Glu Phe Tyr 
             260                265                270
Ala Asn Asn Met Tyr Leu Asn Phe Ala Glu Ile Gly Ser Asn Ile Lys 
         275                280                285
Asn Leu Met Glu Asp Phe Gln Lys Lys Arg Pro Lys Glu Gln Gln Lys 
     290                295                300
Leu Glu Ser Ile Ala Asp Met Lys Ala Phe Val Glu Asn Tyr Pro Gln 
 305                310                315                320
Phe Lys Lys Met Ser Gly Thr Val Ser Lys His Val Thr Val Val Gly 
                 325                330                335
Glu Leu Ser Arg Leu Val Ser Glu Arg Asn Leu Leu Glu Val Ser Glu 
             340                345                350
Val Glu Gln Glu Leu Ala Cys Gln Asn Asp His Ser Ser Ala Leu Gln 
         355                360                365
Asn Val Lys Arg Leu Leu Gln Asn Pro Lys Val Thr Glu Phe Asp Ala 
     370                375                380
Val Arg Leu Val Met Leu Tyr Ala Leu His Tyr Glu Arg His Ser Ser 
 385                390                395                400
Asn Ser Leu Pro Gly Leu Ile Val Asp Leu Arg Ser Lys Gly Val Ala 
                 405                410                415
Glu Lys Tyr Arg Lys Leu Val Ser Ala Val Val Glu Tyr Gly Gly Lys 
             420                425                430
Arg Val Arg Gly Ser Asp Leu Phe Ser Pro Lys Asp Ala Val Ala Ile 
         435                440                445
Thr Lys Gln Phe Leu Lys Gly Leu Lys Gly Val Glu Asn Val Tyr Thr 
     450                455                460
Gln His Gln Pro Phe Leu His Glu Thr Leu Asp His Leu Ile Lys Gly 
 465                470                475                480
Lys Leu Lys Glu Asn Leu Tyr Pro Tyr Leu Gly Pro Ser Thr Leu Arg 
                 485                490                495
Asp Arg Pro Gln Asp Ile Ile Val Phe Val Ile Gly Gly Ala Thr Tyr 
             500                505                510
Glu Glu Ala Leu Thr Val Tyr Asn Leu Asn Arg Thr Thr Pro Gly Val 
         515                520                525
Arg Ile Val Leu Gly Gly Thr Thr Ile His Asn Thr Lys Ser Phe Leu 
     530                535                540
Glu Glu Val Leu Ala Ser Gly Leu His Ser Arg Ser Arg Glu Ser Ser 
 545                550                555                560
Gln Ala Thr Ser Arg Ser Ala Ser Arg Arg 
                 565                570



<210> 7141
<211> 1987
<212> DNA
<213> Homo sapiens
<308> U35246
<400> 7141

ttcggcacg  gaagggctg  agggtactt  tcaattcgc  gccatgaac  tggtttttg  60
tgtgaagca  tacatttcc  aaatgatag  ggacagcgg  cctggtatg  aagtacttc  120
catggataa  gagacgact  gcatagtga  tatggtata  acacaatcg  agattctac  180
gaaggaagt  tacctcttt  aacgcattg  ttctcaaaa  cgagagatc  tgaaacacc  240
gaaggcaat  tgtttcctt  gacctacaa  ggagaatgt  gattctctg  tccaggagc  300
ccgaagacc  aagtatagc  tatatttta  ttatttcag  aatgtgatc  gcaagagtg  360
cgtgaagtc  ttggctgaa  ctgacgagc  ggaagttgt  gctgaagtt  aggaatttt  420
tggagatta  attgctgtg  atccacatt  gttttccct  aatatcttg  gctgctgtc  480
gggtcgaaa  tgggatcca  cccagctat  cagaaccac  caagggctg  ccgctctcc  540
tttgtctct  aagaagtgt  ccatgattc  ttatcagct  tcatcagag  ctgcaaaga  600
actgggaga  tgtgttaag  aagtgataa  taaagagta  gaactcttt  agttccggc  660
gacagaggt  cctccactg  ttctcattc  ggatcgctg  gatgatgcc  tcaccccac  720
gctcaacca  tggacatat  aggccatgg  ccatgaact  ctggacata  acaacaacc  780
gattgatct  tccagagtg  caggaatca  caaagactt  agagaggtg  tcctgtccg  840
tgaaaatga  gaattctat  ctaataaca  gtacctgaa  tttgccgag  ttggtagca  900
tataaagaa  ctcatggaa  atttccaga  gaagagacc  aaagagcag  aaaagctag  960
gtccatagc  gacatgaag  cctttgttg  aaattatcc  caattcaag  agatgtctg  1020
gactgtctc  aagcatgtg  cagtcgttg  ggaactgtc  cggttggtc  gtgaacgaa  1080
cctgctgga  gtttcagag  ttgagcaag  actggcctg  cagaatgac  attctagtg  1140
tcttcagaa  gtgaagaga  tcctgcaga  tccgaaagt  acagaattt  atgcagttc  1200
cctggtgat  ctttatgct  tacattatg  gcgccacag  agcaacagc  tgccagggc  1260
catagtgga  ctcaggagt  aaggtgtcg  tgagaaata  cggaagctt  tgtctgcag  1320
tgttgaata  ggtggtaaa  gggttagag  aagtgacct  ttcagcccc  aagatgctg  1380
ggctattac  aaacagttc  tcaaaggcc  gaagggagt  gaaaatgtg  acacccagc  1440
ccagccttt  ctgcatgag  ccctggacc  tctcatcaa  gggaagctt  aggaaaacc  1500
ctatccgta  ttaggcccc  gcacactca  agacaggcc  caggacatc  tcgtgttcg  1560
tattggagg  gccacctat  aagaggcac  gacagtcta  aacctcaac  gtaccactc  1620
tggagtgag  atcgttctg  gaggaacaa  aatacacaa  acaaaaagt  tcctagagg  1680
agtcctggc  tctgggctg  acagccgca  cagagagag  tcacaggcc  cctcaaggt  1740
agcaagcag  agatgagat  gcagttgag  acagagaga  tgtcacggc  tccctctta  1800
cccgtctcg  ccttccctg  gaccagggg  ttcagggta  ctcttgtgt  tgctctaac  1860
cactccagg  aaccctgat  cctgaactg  tggcacaca  gccggctgg  actgccaat  1920
atgagccca  cccaaccca  ttgtgattc  gtatcaaat  aatatgttc  ttgtgtatt  1980
gacagca  1987



<210> 7142
<211> 570
<212> PRT
<213> Homo sapiens
<308> NP_009189
<400> 7142

Met Asn Val Val Phe Ala Val Lys Gln Tyr Ile Ser Lys Met Ile Glu 
  1               5                  10                  15
Asp Ser Gly Pro Gly Met Lys Val Leu Leu Met Asp Lys Glu Thr Thr 
             20                  25                  30
Gly Ile Val Ser Met Val Tyr Thr Gln Ser Glu Ile Leu Gln Lys Glu 
         35                  40                  45
Val Tyr Leu Phe Glu Arg Ile Asp Ser Gln Asn Arg Glu Ile Met Lys 
     50                  55                  60
His Leu Lys Ala Ile Cys Phe Leu Arg Pro Thr Lys Glu Asn Val Asp 
 65                  70                  75                  80
Tyr Ile Ile Gln Glu Leu Arg Arg Pro Lys Tyr Thr Ile Tyr Phe Ile 
                 85                  90                  95
Tyr Phe Ser Asn Val Ile Ser Lys Ser Asp Val Lys Ser Leu Ala Glu 
             100                105                110
Ala Asp Glu Gln Glu Val Val Ala Glu Val Gln Glu Phe Tyr Gly Asp 
         115                120                125
Tyr Ile Ala Val Asn Pro His Leu Phe Ser Leu Asn Ile Leu Gly Cys 
     130                135                140
Cys Gln Gly Arg Asn Trp Asp Pro Ala Gln Leu Ser Arg Thr Thr Gln 
 145                150                155                160
Gly Leu Thr Ala Leu Leu Leu Ser Leu Lys Lys Cys Pro Met Ile Arg 
                 165                170                175
Tyr Gln Leu Ser Ser Glu Ala Ala Lys Arg Leu Ala Glu Cys Val Lys 
             180                185                190
Gln Val Ile Thr Lys Glu Tyr Glu Leu Phe Glu Phe Arg Arg Thr Glu 
         195                200                205
Val Pro Pro Leu Leu Leu Ile Leu Asp Arg Cys Asp Asp Ala Ile Thr 
     210                215                220
Pro Leu Leu Asn Gln Trp Thr Tyr Gln Ala Met Val His Glu Leu Leu 
 225                230                235                240
Gly Ile Asn Asn Asn Arg Ile Asp Leu Ser Arg Val Pro Gly Ile Ser 
                 245                250                255
Lys Asp Leu Arg Glu Val Val Leu Ser Ala Glu Asn Asp Glu Phe Tyr 
             260                265                270
Ala Asn Asn Met Tyr Leu Asn Phe Ala Glu Ile Gly Ser Asn Ile Lys 
         275                280                285
Asn Leu Met Glu Asp Phe Gln Lys Lys Lys Pro Lys Glu Gln Gln Lys 
     290                295                300
Leu Glu Ser Ile Ala Asp Met Lys Ala Phe Val Glu Asn Tyr Pro Gln 
 305                310                315                320
Phe Lys Lys Met Ser Gly Thr Val Ser Lys His Val Thr Val Val Gly 
                 325                330                335
Glu Leu Ser Arg Leu Val Ser Glu Arg Asn Leu Leu Glu Val Ser Glu 
             340                345                350
Val Glu Gln Glu Leu Ala Cys Gln Asn Asp His Ser Ser Ala Leu Gln 
         355                360                365
Asn Ile Lys Arg Leu Leu Gln Asn Pro Lys Val Thr Glu Phe Asp Ala 
     370                375                380
Ala Arg Leu Val Met Leu Tyr Ala Leu His Tyr Glu Arg His Ser Ser 
 385                390                395                400
Asn Ser Leu Pro Gly Leu Met Met Asp Leu Arg Asn Lys Gly Val Ser 
                 405                410                415
Glu Lys Tyr Arg Lys Leu Val Ser Ala Val Val Glu Tyr Gly Gly Lys 
             420                425                430
Arg Val Arg Gly Ser Asp Leu Phe Ser Pro Lys Asp Ala Val Ala Ile 
         435                440                445
Thr Lys Gln Phe Leu Lys Gly Leu Lys Gly Val Glu Asn Val Tyr Thr 
     450                455                460
Gln His Gln Pro Phe Leu His Glu Thr Leu Asp His Leu Ile Lys Gly 
 465                470                475                480
Arg Leu Lys Glu Asn Leu Tyr Pro Tyr Leu Gly Pro Ser Thr Leu Arg 
                 485                490                495
Asp Arg Pro Gln Asp Ile Ile Val Phe Val Ile Gly Gly Ala Thr Tyr 
             500                505                510
Glu Glu Ala Leu Thr Val Tyr Asn Leu Asn Arg Thr Thr Pro Gly Val 
         515                520                525
Arg Ile Val Leu Gly Gly Thr Thr Val His Asn Thr Lys Ser Phe Leu 
     530                535                540
Glu Glu Val Leu Ala Ser Gly Leu His Ser Arg Ser Lys Glu Ser Ser 
 545                550                555                560
Gln Val Thr Ser Arg Ser Ala Ser Arg Arg 
                 565                570



<210> 7143
<211> 496
<212> DNA
<213> Rattus norvegicus
<308> AI228407
<400> 7143

attatcaaa  tagtcattt  atggcttta  ttgatacat  aatacatgt  tggaaagaa  60
acatgagtg  tgactggtc  gtcaatttg  aaaacgact  ttcatttta  acacacggt  120
gctggcaac  catcgctac  agtacgcta  tcggcgtcc  ttgttttta  ccctctgtt  180
atacctttt  cctagcacg  ccgccaagt  tttcttgac  gccatttgt  ttcggtagc  240
gctatagct  tctgtgaag  tgccgtccg  gtggcgttt  gtaaggggt  cccgggcgt  300
caccggggc  gcggcaagg  tctcgccca  gcccttggc  accatggac  gcaggtact  360
cctggcgga  agctggtcc  agactttgc  gtaggcttc  ttaaggatt  cgtgggcga  420
atctctcct  tcggctggg  agtaaaggg  gtaggcgtt  cgcagcgcg  aggcggggc  480
ccctgcgcc  ggaggg  496



<210> 7144
<211> 175
<212> PRT
<213> Rattus norvegicus
<308> P13589
<400> 7144

Met Thr Met Cys Ser Gly Ala Arg Leu Ala Leu Leu Val Tyr Gly Ile 
  1               5                  10                  15
Ile Met His Asn Ser Val Ser Cys Ser Pro Ala Ala Gly Leu Ser Phe 
             20                  25                  30
Pro Gly Ile Arg Pro Glu Glu Glu Ala Tyr Asp Gln Asp Gly Asn Pro 
         35                  40                  45
Leu Gln Asp Phe Tyr Asp Trp Asp Pro Pro Gly Ala Gly Ser Pro Ala 
     50                  55                  60
Ser Ala Leu Arg Asp Ala Tyr Ala Leu Tyr Tyr Pro Ala Asp Arg Arg 
 65                  70                  75                  80
Asp Val Ala His Glu Ile Leu Asn Glu Ala Tyr Arg Lys Val Leu Asp 
                 85                  90                  95
Gln Leu Ser Ala Arg Lys Tyr Leu Gln Ser Met Val Ala Arg Gly Met 
             100                105                110
Gly Glu Asn Leu Ala Ala Ala Ala Val Asp Asp Arg Ala Pro Leu Thr 
         115                120                125
Lys Arg His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg 
     130                135                140
Lys Gln Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg 
 145                150                155                160
Tyr Lys Gln Arg Val Lys Asn Lys Gly Arg Arg Ile Ala Tyr Leu 
                 165                170                175



<210> 7145
<211> 372
<212> DNA
<213> Homo sapiens
<308> AI039838
<400> 7145

tttttttga  tgcccggga  gggttatta  gtatgaatt  tacaaactt  acttatatt  60
gcggtaacg  tggagctgg  gagtattgc  ccttctcca  gctgcccgg  gagagccac  120
aatagtgtg  tggaacttg  ggccctttc  aaggccacg  ctctttcgg  ctgcagatg  180
cagcccacg  atctccctg  gcttgtgga  tggtttggt  atccactgg  tgtcaggat  240
tcttctgat  gctttatgg  atggatcaa  gaggataac  tcaaaaaat  tgtatgtgg  300
atcttcacc  acccagtaa  aattcagga  tctcatagc  ccacagtgg  gttcagctc  360
ctcctctgc  ac  372



<210> 7146
<211> 194
<212> PRT
<213> Homo sapiens
<308> Q99653
<400> 7146

Gly Ser Arg Ala Ser Thr Leu Leu Arg Asp Glu Glu Leu Glu Glu Ile 
  1               5                  10                  15
Lys Lys Glu Thr Gly Phe Ser His Ser Gln Ile Thr Arg Leu Tyr Ser 
             20                  25                  30
Arg Phe Thr Ser Leu Asp Lys Gly Glu Asn Gly Thr Leu Ser Arg Glu 
         35                  40                  45
Asp Phe Gln Arg Ile Pro Glu Leu Ala Ile Asn Pro Leu Gly Asp Arg 
     50                  55                  60
Ile Ile Asn Ala Phe Phe Pro Glu Gly Glu Asp Gln Val Asn Phe Arg 
 65                  70                  75                  80
Gly Phe Met Arg Thr Leu Ala His Phe Arg Pro Ile Glu Asp Asn Glu 
                 85                  90                  95
Lys Ser Lys Asp Val Asn Gly Pro Glu Pro Leu Asn Ser Arg Ser Asn 
             100                105                110
Lys Leu His Phe Ala Phe Arg Leu Tyr Asp Leu Asp Lys Asp Glu Lys 
         115                120                125
Ile Ser Arg Asp Glu Leu Leu Gln Val Leu Arg Met Met Val Gly Val 
     130                135                140
Asn Ile Ser Asp Glu Gln Leu Gly Ser Ile Ala Asp Arg Thr Ile Gln 
 145                150                155                160
Glu Ala Asp Gln Asp Gly Asp Ser Ala Ile Ser Phe Thr Glu Phe Val 
                 165                170                175
Lys Val Leu Glu Lys Val Asp Val Glu Gln Lys Met Ser Ile Arg Phe 
             180                185                190
Leu His 
         195



<210> 7147
<211> 572
<212> DNA
<213> Rattus norvegicus
<308> AI228599
<400> 7147

tttattttt  gaactgcta  ggaccaaat  cgagacctt  tacatgctg  gcaagcatt  60
tgccaagtc  tacaattaa  atttggatc  gacagtaac  aagaacaga  ctatgctct  120
cttcccttt  ctagcatta  atgctttgc  ttacatcac  tataccaga  acacaatag  180
tttctgtta  agttagtat  ccttatctc  gtcaaagaa  ataagattt  gccagacaa  240
cttgttctc  gtggccatc  aagtgttat  tcaggaagg  aggcaaagg  gggacatta  300
actcagcac  tttgcagtg  tggtagctt  agcgctttg  cctttaaca  gttactgta  360
ctcggagag  caagttctt  gtcatccac  gacttcata  tcatgtcag  acaagagac  420
agtagttag  tctttgctg  ccttgcagc  atctccttg  ggaactctt  gagaatttc  480
aactggctg  gcctgatgg  gatgtgtga  cggattttg  cgatagctt  tatagcctc  540
tatgggctt  agttgtgta  ctgaatcaa  ta  572



<210> 7148
<211> 1526
<212> PRT
<213> Rattus norvegicus
<308> P41516
<400> 7148

Met Glu Leu Ser Pro Leu Gln Pro Val Asn Glu Asn Met Leu Leu Asn 
  1               5                  10                  15
Lys Lys Lys Asn Glu Asp Gly Lys Lys Arg Leu Ser Val Glu Arg Ile 
             20                  25                  30
Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp Thr 
         35                  40                  45
Tyr Ile Gly Ser Val Glu Leu Val Thr Gln Gln Met Trp Val Tyr Asp 
     50                  55                  60
Glu Asp Val Gly Ile Asn Tyr Arg Glu Val Thr Phe Val Pro Gly Leu 
 65                  70                  75                  80
Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys Gln 
                 85                  90                  95
Arg Asp Pro Lys Met Ser Cys Ile Arg Val Thr Met Met Arg Asn Asn 
             100                105                110
Leu Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val Glu His 
         115                120                125
Lys Val Glu Lys Met Tyr Val Pro Ala Leu Ile Phe Gly Gln Leu Leu 
     130                135                140
Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly Gly Arg 
 145                150                155                160
Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys Phe Thr 
                 165                170                175
Val Glu Thr Ala Ser Arg Glu Tyr Lys Lys Met Phe Lys Gln Thr Trp 
             180                185                190
Met Asp Asn Met Gly Arg Ala Gly Asp Met Glu Leu Lys Pro Phe Ser 
         195                200                205
Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser Lys Phe 
     210                215                220
Lys Met Gln Ser Leu Asp Lys Asp Ile Val Ala Leu Met Val Arg Arg 
 225                230                235                240
Ala Tyr Asp Ile Ala Gly Ser Thr Lys Asp Val Lys Val Phe Leu Asn 
                 245                250                255
Gly Asn Arg Leu Pro Val Lys Gly Phe Arg Ser Tyr Val Asp Met Tyr 
             260                265                270
Leu Lys Asp Lys Val Asp Glu Thr Gly Asn Ala Leu Lys Val Val His 
         275                280                285
Glu Gln Val Asn Pro Arg Trp Glu Val Cys Leu Thr Met Ser Glu Lys 
     290                295                300
Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Ser Lys Gly 
 305                310                315                320
Gly Arg His Val Asp Tyr Val Ala Asp Gln Ile Val Ser Lys Leu Val 
                 325                330                335
Asp Val Val Lys Lys Lys Asn Lys Gly Gly Val Ala Val Lys Ala Asp 
             340                345                350
Gln Val Lys Asn His Met Trp Ile Phe Gly Asn Ala Val Ile Glu Asn 
         355                360                365
Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn Met Thr Leu Gln Ala Lys 
     370                375                380
Ser Phe Gly Ser Thr Cys Gln Leu Ser Glu Lys Phe Ile Lys Ala Ala 
 385                390                395                400
Ile Gly Cys Gly Ile Val Glu Ser Ile Leu Asn Trp Val Lys Phe Lys 
                 405                410                415
Ala Gln Ile Gln Leu Asn Lys Lys Cys Ser Ala Val Lys His Asn Arg 
             420                425                430
Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala Asn Asp Ala Gly Ser Arg 
         435                440                445
Asn Ser Ala Glu Cys Thr Leu Ile Leu Thr Glu Gly Asp Ser Ala Lys 
     450                455                460
Thr Leu Ala Val Ser Gly Leu Gly Val Val Gly Arg Asp Lys Tyr Gly 
 465                470                475                480
Val Phe Pro Leu Arg Gly Lys Ile Leu Asn Val Arg Glu Ala Ser His 
                 485                490                495
Lys Gln Ile Met Glu Asn Ala Glu Ile Asn Asn Ile Ile Lys Ile Val 
             500                505                510
Gly Leu Gln Tyr Lys Lys Asn Tyr Glu Asp Glu Asp Ser Leu Lys Thr 
         515                520                525
Leu Arg Tyr Gly Lys Ile Met Ile Met Thr Asp Gln Asp Gln Asp Gly 
     530                535                540
Ser His Ile Lys Gly Leu Leu Ile Asn Phe Ile His His Asn Trp Pro 
 545                550                555                560
Ser Leu Leu Arg His Arg Phe Leu Glu Glu Phe Ile Thr Pro Ile Val 
                 565                570                575
Lys Val Ser Lys Asn Lys Gln Glu Ile Ala Phe Tyr Ser Leu Pro Glu 
             580                585                590
Phe Glu Glu Trp Lys Ser Thr Asn Pro Asn His Lys Lys Trp Lys Val 
         595                600                605
Lys Tyr Tyr Lys Gly Leu Gly Thr Ser Thr Ser Lys Glu Ala Lys Glu 
     610                615                620
Tyr Phe Ala Asn Met Lys Arg His Arg Ile Gln Phe Lys Tyr Ser Gly 
 625                630                635                640
Pro Glu Asp Asp Ala Ala Ile Ser Leu Ala Phe Ser Lys Lys Gln Val 
                 645                650                655
Asp Asp Arg Lys Glu Trp Leu Thr Asn Phe Met Glu Asp Arg Arg Gln 
             660                665                670
Arg Lys Leu Leu Gly Leu Pro Glu Asp Tyr Leu Tyr Gly Gln Thr Thr 
         675                680                685
Met Tyr Leu Thr Tyr Asn Asp Phe Ile Asn Lys Glu Leu Ile Leu Phe 
     690                695                700
Ser Asn Ser Asp Asn Glu Arg Ser Ile Pro Ser Met Val Asp Gly Leu 
 705                710                715                720
Lys Pro Gly Gln Arg Lys Val Leu Phe Thr Cys Phe Lys Arg Asn Asp 
                 725                730                735
Lys Arg Glu Val Lys Val Ala Gln Leu Ala Gly Ser Val Ala Glu Met 
             740                745                750
Ser Ser Tyr His His Gly Glu Met Ser Leu Met Met Thr Ile Ile Asn 
         755                760                765
Leu Ala Gln Asn Phe Val Gly Ser Asn Asn Leu Asn Leu Leu Gln Pro 
     770                775                780
Ile Gly Gln Phe Gly Thr Arg Leu His Gly Gly Lys Asp Ser Ala Ser 
 785                790                795                800
Pro Arg Tyr Ile Phe Thr Met Leu Ser Pro Leu Ala Arg Leu Leu Phe 
                 805                810                815
Pro Ser Lys Asp Asp His Thr Leu Arg Phe Leu Tyr Asp Asp Asn Gln 
             820                825                830
Arg Val Glu Pro Glu Trp Tyr Ile Pro Ile Ile Pro Met Val Leu Ile 
         835                840                845
Asn Gly Ala Glu Gly Ile Gly Thr Gly Trp Ser Cys Lys Ile Pro Asn 
     850                855                860
Phe Asp Val Arg Glu Val Val Asn Asn Ile Arg Arg Leu Leu Asp Gly 
 865                870                875                880
Glu Glu Pro Leu Pro Met Leu Pro Ser Tyr Lys Asn Tyr Lys Gly Thr 
                 885                890                895
Ile Glu Glu Leu Ala Ser Asn Gln Tyr Val Ile Asn Gly Glu Val Ala 
             900                905                910
Ile Leu Asn Ser Thr Thr Ile Glu Ile Thr Glu Leu Pro Ile Arg Thr 
         915                920                925
Trp Thr Gln Thr Tyr Lys Glu Gln Val Leu Glu Pro Met Leu Asn Gly 
     930                935                940
Thr Glu Lys Thr Pro Pro Leu Ile Thr Asp Tyr Arg Glu Tyr His Thr 
 945                950                955                960
Asp Thr Thr Val Lys Phe Val Ile Lys Met Thr Glu Glu Lys Leu Ala 
                 965                970                975
Glu Ala Glu Arg Val Gly Leu His Lys Val Phe Lys Leu Gln Thr Ser 
             980                985                990
Leu Thr Cys Asn Ser Met Val Leu Phe Asp His Val Gly Cys Leu Lys 
         995                1000                1005
Lys Tyr Asp Thr Val Leu Asp Ile Leu Arg Asp Phe Phe Glu Leu Arg 
     1010                1015                1020
Leu Lys Tyr Tyr Gly Leu Arg Lys Glu Trp Leu Leu Gly Met Leu Gly 
 1025                1030                1035                1040
Ala Glu Ser Ser Lys Leu Asn Asn Gln Ala Arg Phe Ile Leu Glu Lys 
                 1045                1050                1055
Ile Asp Gly Lys Ile Val Ile Glu Asn Lys Pro Lys Lys Glu Leu Ile 
             1060                1065                1070
Lys Val Leu Ile Gln Arg Gly Tyr Asp Ser Asp Pro Val Lys Ala Trp 
         1075                1080                1085
Lys Glu Ala Gln Gln Lys Val Pro Glu Glu Glu Glu Asn Glu Glu Asn 
     1090                1095                1100
Glu Glu Ser Glu Ser Glu Ser Thr Ser Pro Ala Ala Glu Ser Gly Pro 
 1105                1110                1115                1120
Thr Phe Asn Tyr Leu Leu Asp Met Pro Leu Trp Tyr Leu Thr Lys Glu 
                 1125                1130                1135
Lys Lys Asp Glu Leu Cys Lys Gln Arg Asp Glu Lys Glu Gln Glu Leu 
             1140                1145                1150
Asn Thr Leu Lys Lys Lys Thr Pro Ser Asp Leu Trp Lys Glu Asp Leu 
         1155                1160                1165
Ala Ala Phe Val Glu Glu Leu Glu Val Val Glu Ala Lys Glu Lys Gln 
     1170                1175                1180
Asp Glu Gln Val Gly Leu Pro Gly Lys Gly Val Lys Ala Lys Gly Lys 
 1185                1190                1195                1200
Lys Ala Gln Ile Ser Glu Val Leu Pro Ser Pro Val Gly Lys Arg Val 
                 1205                1210                1215
Ile Pro Gln Val Thr Met Glu Met Arg Ala Glu Ala Glu Lys Lys Ile 
             1220                1225                1230
Arg Arg Lys Ile Lys Ser Glu Asn Val Glu Gly Thr Pro Ala Glu Asp 
         1235                1240                1245
Gly Ala Glu Pro Gly Leu Arg Gln Arg Leu Glu Lys Arg Gln Lys Arg 
     1250                1255                1260
Glu Pro Gly Thr Arg Ala Lys Lys Gln Thr Thr Leu Pro Phe Lys Pro 
 1265                1270                1275                1280
Ile Lys Lys Ala Gln Lys Gln Asn Pro Trp Ser Asp Ser Glu Ser Asp 
                 1285                1290                1295
Met Ser Ser Asn Glu Ser Asn Phe Asp Val Pro Pro Arg Glu Lys Glu 
             1300                1305                1310
Pro Arg Ile Ala Ala Thr Lys Ala Lys Phe Thr Ala Asp Leu Asp Ser 
         1315                1320                1325
Asp Asp Asp Phe Ser Gly Leu Asp Glu Lys Asp Glu Asp Glu Asp Phe 
     1330                1335                1340
Phe Pro Leu Asp Asp Thr Pro Pro Lys Thr Lys Met Pro Pro Lys Asn 
 1345                1350                1355                1360
Thr Lys Lys Ala Leu Lys Pro Gln Lys Ser Ser Thr Ser Val Asp Leu 
                 1365                1370                1375
Glu Ser Asp Gly Lys Asp Ser Val Pro Ala Ser Pro Gly Ala Ser Ala 
             1380                1385                1390
Ala Asp Val Pro Ala Glu Thr Glu Pro Ser Lys Pro Ser Ser Lys Gln 
         1395                1400                1405
Thr Val Gly Val Lys Arg Thr Ile Thr Lys Gly Gln Ser Leu Thr Ser 
     1410                1415                1420
Thr Ala Gly Thr Lys Lys Arg Ala Val Pro Lys Glu Thr Lys Ser Asp 
 1425                1430                1435                1440
Ser Ala Leu Asn Ala His Val Ser Lys Lys Pro Ala Pro Ala Lys Ala 
                 1445                1450                1455
Lys Asn Ser Arg Lys Arg Met Pro Ser Ser Ser Asp Ser Ser Asp Ser 
             1460                1465                1470
Glu Phe Glu Lys Ala Ile Ser Lys Gly Ala Thr Ser Lys Lys Leu Lys 
         1475                1480                1485
Gly Glu Glu Arg Asp Phe His Val Asp Leu Asp Asp Thr Val Ala Pro 
     1490                1495                1500
Arg Ala Lys Ser Gly Arg Ala Arg Lys Pro Ile Lys Tyr Leu Glu Glu 
 1505                1510                1515                1520
Ser Asp Asp Asp Leu Phe 
                 1525



<210> 7149
<211> 1213
<212> DNA
<213> Homo sapiens
<308> AK024080
<400> 7149

tggagaaga  cctttgcca  tgcttccaa  ttacaagaa  ttcaagggt  ctattgaag  60
actggctcc  aatcaatat  tgattagtg  tgaagtagc  attcttaat  ctacaacca  120
tgaaatctc  gagcttccc  tcagaacat  gacccagac  tacaaagaa  aagttctag  180
acccatgtt  aatggcacc  agaagacac  tcctctcat  acagactat  gggaatacc  240
tacagatac  actgtgaaa  ttgttgtga  gatgactga  gaaaaactg  cagaggcag  300
gagagttgg  ctacacaaa  tcttcaaac  ccaaactag  ctcacatgc  actctatgg  360
gctttttga  cacgtaggc  gtttaaaga  atatgacac  gtgttggat  ttctaagag  420
cttttttga  ctcagactt  aatattatg  attaagaaa  gaatggctc  taggaatgc  480
tggtgctga  tctgctaaa  tgaataatc  ggctcgctt  atcttagag  aaatagatg  540
caaaataat  attgaaaat  agcctaaga  agaattaat  aaagttctg  ttcagaggg  600
atatgattc  gatcctgtg  aggcctgga  agaagccca  caaaaggtt  cagatgaag  660
agaaaatga  gagagtgac  acgaaaagg  aactgaaaa  agtgactcc  taacagatt  720
tggaccaac  ttcaactat  ttcttgata  gcccctttg  tatttaacc  aggaaaaga  780
agatgaact  tgcaggcta  gaaatgaaa  agaacaaga  ctggacaca  taaaaagaa  840
gagtccatc  gatttgtgg  aagaagact  ggctacatt  attgaagaa  tggaggctg  900
tgaagccaa  gaaaaacaa  atgaacaag  cggacttcc  gggaaaggg  ggaaggcca  960
ggggaaaaa  acacaaatg  ctgaagttt  gccttctcc  cgtggtcaa  gagtcattc  1020
acgaataac  atagaaatg  aagcagagg  agaaaagaa  aataaaaag  aaattaaga  1080
tgaaaatac  gaaggaagc  ctcaagaag  tggtgtgga  ctagaaggc  taaaacaaa  1140
attagaaaa  aaacagaaa  gagaaccag  tacaaagac  aagaaacaa  ctacattgg  1200
atttaagcc  atc  1213



<210> 7150
<211> 1531
<212> PRT
<213> Homo sapiens
<308> P11388
<400> 7150

Met Glu Val Ser Pro Leu Gln Pro Val Asn Glu Asn Met Gln Val Asn 
  1               5                  10                  15
Lys Ile Lys Lys Asn Glu Asp Ala Lys Lys Arg Leu Ser Val Glu Arg 
             20                  25                  30
Ile Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp 
         35                  40                  45
Thr Tyr Ile Gly Ser Val Glu Leu Val Thr Gln Gln Met Trp Val Tyr 
     50                  55                  60
Asp Glu Asp Val Gly Ile Asn Tyr Arg Glu Val Thr Phe Val Pro Gly 
 65                  70                  75                  80
Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys 
                 85                  90                  95
Gln Arg Asp Pro Lys Met Ser Cys Ile Arg Val Thr Ile Asp Pro Glu 
             100                105                110
Asn Asn Leu Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val 
         115                120                125
Glu His Lys Val Glu Lys Met Tyr Val Pro Ala Leu Ile Phe Gly Gln 
     130                135                140
Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly 
 145                150                155                160
Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys 
                 165                170                175
Phe Thr Val Glu Thr Ala Ser Arg Glu Tyr Lys Lys Met Phe Lys Gln 
             180                185                190
Thr Trp Met Asp Asn Met Gly Arg Ala Gly Glu Met Glu Leu Lys Pro 
         195                200                205
Phe Asn Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser 
     210                215                220
Lys Phe Lys Met Gln Ser Leu Asp Lys Asp Ile Val Ala Leu Met Val 
 225                230                235                240
Arg Arg Ala Tyr Asp Ile Ala Gly Ser Thr Lys Asp Val Lys Val Phe 
                 245                250                255
Leu Asn Gly Asn Lys Leu Pro Val Lys Gly Phe Arg Ser Tyr Val Asp 
             260                265                270
Met Tyr Leu Lys Asp Lys Leu Asp Glu Thr Gly Asn Ser Leu Lys Val 
         275                280                285
Ile His Glu Gln Val Asn His Arg Trp Glu Val Cys Leu Thr Met Ser 
     290                295                300
Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Ser 
 305                310                315                320
Lys Gly Gly Arg His Val Asp Tyr Val Ala Asp Gln Ile Val Thr Lys 
                 325                330                335
Leu Val Asp Val Val Lys Lys Lys Asn Lys Gly Gly Val Ala Val Lys 
             340                345                350
Ala His Gln Val Lys Asn His Met Trp Ile Phe Val Asn Ala Leu Ile 
         355                360                365
Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn Met Thr Leu Gln 
     370                375                380
Pro Lys Ser Phe Gly Ser Thr Cys Gln Leu Ser Glu Lys Phe Ile Lys 
 385                390                395                400
Ala Ala Ile Gly Cys Gly Ile Val Glu Ser Ile Leu Asn Trp Val Lys 
                 405                410                415
Phe Lys Ala Gln Val Gln Leu Asn Lys Lys Cys Ser Ala Val Lys His 
             420                425                430
Asn Arg Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala Asn Asp Ala Gly 
         435                440                445
Gly Arg Asn Ser Thr Glu Cys Thr Leu Ile Leu Thr Glu Gly Asp Ser 
     450                455                460
Ala Lys Thr Leu Ala Val Ser Gly Leu Gly Val Val Gly Arg Asp Lys 
 465                470                475                480
Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu Asn Val Arg Glu Ala 
                 485                490                495
Ser His Lys Gln Ile Met Glu Asn Ala Glu Ile Asn Asn Ile Ile Lys 
             500                505                510
Ile Val Gly Leu Gln Tyr Lys Lys Asn Tyr Glu Asp Glu Asp Ser Leu 
         515                520                525
Lys Thr Leu Arg Tyr Gly Lys Ile Met Ile Met Thr Asp Gln Asp Gln 
     530                535                540
Asp Gly Ser His Ile Lys Gly Leu Leu Ile Asn Phe Ile His His Asn 
 545                550                555                560
Trp Pro Ser Leu Leu Arg His Arg Phe Leu Glu Glu Phe Ile Thr Pro 
                 565                570                575
Ile Val Lys Val Ser Lys Asn Lys Gln Glu Met Ala Phe Tyr Ser Leu 
             580                585                590
Pro Glu Phe Glu Glu Trp Lys Ser Ser Thr Pro Asn His Lys Lys Trp 
         595                600                605
Lys Val Lys Tyr Tyr Lys Gly Leu Gly Thr Ser Thr Ser Lys Glu Ala 
     610                615                620
Lys Glu Tyr Phe Ala Asp Met Lys Arg His Arg Ile Gln Phe Lys Tyr 
 625                630                635                640
Ser Gly Pro Glu Asp Asp Ala Ala Ile Ser Leu Ala Phe Ser Lys Lys 
                 645                650                655
Gln Ile Asp Asp Arg Lys Glu Trp Leu Thr Asn Phe Met Glu Asp Arg 
             660                665                670
Arg Gln Arg Lys Leu Leu Gly Leu Pro Glu Asp Tyr Leu Tyr Gly Gln 
         675                680                685
Thr Thr Thr Tyr Leu Thr Tyr Asn Asp Phe Ile Asn Lys Glu Leu Ile 
     690                695                700
Leu Phe Ser Asn Ser Asp Asn Glu Arg Ser Ile Pro Ser Met Val Asp 
 705                710                715                720
Gly Leu Lys Pro Gly Gln Arg Lys Val Leu Phe Thr Cys Phe Lys Arg 
                 725                730                735
Asn Asp Lys Arg Glu Val Lys Val Ala Gln Leu Ala Gly Ser Val Ala 
             740                745                750
Glu Met Ser Ser Tyr His His Gly Glu Met Ser Leu Met Met Thr Ile 
         755                760                765
Ile Asn Leu Ala Gln Asn Phe Val Gly Ser Asn Asn Leu Asn Leu Leu 
     770                775                780
Gln Pro Ile Gly Gln Phe Gly Thr Arg Leu His Gly Gly Lys Asp Ser 
 785                790                795                800
Ala Ser Pro Arg Tyr Ile Phe Thr Met Leu Ser Ser Leu Ala Arg Leu 
                 805                810                815
Leu Phe Pro Pro Lys Asp Asp His Thr Leu Lys Phe Leu Tyr Asp Asp 
             820                825                830
Asn Gln Arg Val Glu Pro Glu Trp Tyr Ile Pro Ile Ile Pro Met Val 
         835                840                845
Leu Ile Asn Gly Ala Glu Gly Ile Gly Thr Gly Trp Ser Cys Lys Ile 
     850                855                860
Pro Asn Phe Asp Val Arg Glu Ile Val Asn Asn Ile Arg Arg Leu Met 
 865                870                875                880
Asp Gly Glu Glu Pro Leu Pro Met Leu Pro Ser Tyr Lys Asn Phe Lys 
                 885                890                895
Gly Thr Ile Glu Glu Leu Ala Pro Asn Gln Tyr Val Ile Ser Gly Glu 
             900                905                910
Val Ala Ile Leu Asn Ser Thr Thr Ile Glu Ile Ser Glu Leu Pro Val 
         915                920                925
Arg Thr Trp Thr Gln Thr Tyr Lys Glu Gln Val Leu Glu Pro Met Leu 
     930                935                940
Asn Gly Thr Glu Lys Thr Pro Pro Leu Ile Thr Asp Tyr Arg Glu Tyr 
 945                950                955                960
His Thr Asp Thr Thr Val Lys Phe Val Val Lys Met Thr Glu Glu Lys 
                 965                970                975
Leu Ala Glu Ala Glu Arg Val Gly Leu His Lys Val Phe Lys Leu Gln 
             980                985                990
Thr Ser Leu Thr Cys Asn Ser Met Val Leu Phe Asp His Val Gly Cys 
         995                1000                1005
Leu Lys Lys Tyr Asp Thr Val Leu Asp Ile Leu Arg Asp Phe Phe Glu 
     1010                1015                1020
Leu Arg Leu Lys Tyr Tyr Gly Leu Arg Lys Glu Trp Leu Leu Gly Met 
 1025                1030                1035                1040
Leu Gly Ala Glu Ser Ala Lys Leu Asn Asn Gln Ala Arg Phe Ile Leu 
                 1045                1050                1055
Glu Lys Ile Asp Gly Lys Ile Ile Ile Glu Asn Lys Pro Lys Lys Glu 
             1060                1065                1070
Leu Ile Lys Val Leu Ile Gln Arg Gly Tyr Asp Ser Asp Pro Val Lys 
         1075                1080                1085
Ala Trp Lys Glu Ala Gln Gln Lys Val Pro Asp Glu Glu Glu Asn Glu 
     1090                1095                1100
Glu Ser Asp Asn Glu Lys Glu Thr Glu Lys Ser Asp Ser Val Thr Asp 
 1105                1110                1115                1120
Ser Gly Pro Thr Phe Asn Tyr Leu Leu Asp Met Pro Leu Trp Tyr Leu 
                 1125                1130                1135
Thr Lys Glu Lys Lys Asp Glu Leu Cys Arg Leu Arg Asn Glu Lys Glu 
             1140                1145                1150
Gln Glu Leu Asp Thr Leu Lys Arg Lys Ser Pro Ser Asp Leu Trp Lys 
         1155                1160                1165
Glu Asp Leu Ala Thr Phe Ile Glu Glu Leu Glu Ala Val Glu Ala Lys 
     1170                1175                1180
Glu Lys Gln Asp Glu Gln Val Gly Leu Pro Gly Lys Gly Gly Lys Ala 
 1185                1190                1195                1200
Lys Gly Lys Lys Thr Gln Met Ala Glu Val Leu Pro Ser Pro Arg Gly 
                 1205                1210                1215
Gln Arg Val Ile Pro Arg Ile Thr Ile Glu Met Lys Ala Glu Ala Glu 
             1220                1225                1230
Lys Lys Asn Lys Lys Lys Ile Lys Asn Glu Asn Thr Glu Gly Ser Pro 
         1235                1240                1245
Gln Glu Asp Gly Val Glu Leu Glu Gly Leu Lys Gln Arg Leu Glu Lys 
     1250                1255                1260
Lys Gln Lys Arg Glu Pro Gly Thr Lys Thr Lys Lys Gln Thr Thr Leu 
 1265                1270                1275                1280
Ala Phe Lys Pro Ile Lys Lys Gly Lys Lys Arg Asn Pro Trp Ser Asp 
                 1285                1290                1295
Ser Glu Ser Asp Arg Ser Ser Asp Glu Ser Asn Phe Asp Val Pro Pro 
             1300                1305                1310
Arg Glu Thr Glu Pro Arg Arg Ala Ala Thr Lys Thr Lys Phe Thr Met 
         1315                1320                1325
Asp Leu Asp Ser Asp Glu Asp Phe Ser Asp Phe Asp Glu Lys Thr Asp 
     1330                1335                1340
Asp Glu Asp Phe Val Pro Ser Asp Ala Ser Pro Pro Lys Thr Lys Thr 
 1345                1350                1355                1360
Ser Pro Lys Leu Ser Asn Lys Glu Leu Lys Pro Gln Lys Ser Val Val 
                 1365                1370                1375
Ser Asp Leu Glu Ala Asp Asp Val Lys Gly Ser Val Pro Leu Ser Ser 
             1380                1385                1390
Ser Pro Pro Ala Thr His Phe Pro Asp Glu Thr Glu Ile Thr Asn Pro 
         1395                1400                1405
Val Pro Lys Lys Asn Val Thr Val Lys Lys Thr Ala Ala Lys Ser Gln 
     1410                1415                1420
Ser Ser Thr Ser Thr Thr Gly Ala Lys Lys Arg Ala Ala Pro Lys Gly 
 1425                1430                1435                1440
Thr Lys Arg Asp Pro Ala Leu Asn Ser Gly Val Ser Gln Lys Pro Asp 
                 1445                1450                1455
Pro Ala Lys Thr Lys Asn Arg Arg Lys Arg Lys Pro Ser Thr Ser Asp 
             1460                1465                1470
Asp Ser Asp Ser Asn Phe Glu Lys Ile Val Ser Lys Ala Val Thr Ser 
         1475                1480                1485
Lys Lys Ser Lys Gly Glu Ser Asp Asp Phe His Met Asp Phe Asp Ser 
     1490                1495                1500
Ala Val Ala Pro Arg Ala Lys Ser Val Arg Ala Lys Lys Pro Ile Lys 
 1505                1510                1515                1520
Tyr Leu Glu Glu Ser Asp Glu Asp Asp Leu Phe 
                 1525                1530



<210> 7151
<211> 545
<212> DNA
<213> Rattus norvegicus
<308> AI228675
<400> 7151

gaagtttcc  acaaggttt  cttcaatgc  attcagcag  aaatgatca  agaaagaat  60
ctaagaccc  ctggacaca  taaggtcaa  gacttccaa  ttaatccac  tttcttccc  120
cacgagttt  tttttggta  aaggcagaa  aattagttt  tacaaggaa  atctgcttc  180
aaatgataa  ttgaaaatc  cgatatata  attatatat  aaaaaagac  caaaaataa  240
ggagaagtg  gaataacag  ttaggtact  taattttat  aaggcttgc  tagaccaag  300
agcagcaca  acctcattt  tgcacacta  gaaggtata  aaacagcag  gcactgcaa  360
actgggtct  gacacatta  tgtacacaa  tactactgg  attaataac  tttgggaca  420
tgtcttatg  ccaacgaga  atcattaag  ctttaagtc  tatttgtcc  ctctgggga  480
ggcatttct  gacactaat  tcccatcta  atttcaaat  taggaaaca  actccacaa  540
gtgct  545



<210> 7152
<211> 467
<212> PRT
<213> Rattus norvegicus
<308> O70436
<400> 7152

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
  1               5                  10                  15
Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
             20                  25                  30
Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
         35                  40                  45
Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
     50                  55                  60
Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Ser Thr 
 65                  70                  75                  80
Cys Ser Glu Ile Trp Gly Leu Ser Thr Ala Asn Thr Val Asp Gln Trp 
                 85                  90                  95
Asp Thr Thr Gly Leu Tyr Ser Phe Ser Glu Gln Thr Arg Ser Leu Asp 
             100                105                110
Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr 
         115                120                125
Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu Leu Lys 
     130                135                140
Ala Ile Glu Asn Cys Glu Tyr Ala Phe Ser Leu Lys Lys Asp Glu Val 
 145                150                155                160
Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val Leu Pro 
                 165                170                175
Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu Pro Pro 
             180                185                190
Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe Pro Ala 
         195                200                205
Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro Pro Gly 
     210                215                220
Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn Gln Ser 
 225                230                235                240
Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu Ser Pro 
                 245                250                255
Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu Pro Ala 
             260                265                270
Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu 
         275                280                285
Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp 
     290                295                300
Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn 
 305                310                315                320
Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val 
                 325                330                335
Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp 
             340                345                350
Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp 
         355                360                365
His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile 
     370                375                380
Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln 
 385                390                395                400
Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met 
                 405                410                415
Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr 
             420                425                430
Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp 
         435                440                445
Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser 
     450                455                460
Ser Met Ser 
 465



<210> 7153
<211> 2041
<212> DNA
<213> Homo sapiens
<308> U68018
<400> 7153

aggttcgat  caagaggct  ttttcctag  gtggcttgc  gcctttggt  agaacatgt  60
gtccatctt  ccattcacg  cgccagttg  gaagagact  ctgggatgg  agaagtcag  120
tggtgggtc  ggaggagca  gcggaggag  gcagaatgg  caggaagaa  agtggtgtg  180
gaaagcagt  aaaagtctg  tgaagaagc  aaagaaaac  ggacgatta  atgagcttg  240
gaaagccat  accactcaa  actgtaata  taaatgtgt  accatacca  gcacttgct  300
tgaaatttg  ggactgagt  caccaaata  gatagatca  tgggataca  caggccttt  360
cagcttctc  gaacaaacc  ggtctcttg  tggtcgtct  caggtatcc  atcgaaaag  420
attgccaca  gttatatat  gccgattat  gcgctggcc  gatcttcac  gtcatcatg  480
actcaaggc  attgaaaac  gcgaatatg  ttttaatct  aaaaaggat  aagtatgtg  540
aaaccctta  cactatcag  gagttgaga  accagtttt  cctccagta  tagtgcccc  600
acacaccga  atcctaaca  aacttccgc  tctggatga  tatactcac  ccattccag  660
aaacactaa  ttcccagca  gaattgagc  acagagtaa  tatattcca  aaacgccac  720
tcctggata  atcagtgaa  atggagaaa  aagtgacca  cagttgaat  aaagtatgg  780
cacaggctc  ccagcagaa  tatctccta  tactctttc  cctgttaat  atagcttgg  840
tttacagcc  gttacttac  cagaacctg  attttggtg  tcaatagca  attatgaat  900
aaatcagag  gttggagaa  ccttccatg  atcacagcc  tcactcact  tagatggct  960
tacagaccc  tcaaattca  agaggttct  cttaggttt  ctctccaat  ttaaccgaa  1020
tgccacggt  gaaatgaca  gaaggcata  aggaagagg  gtgcgctta  actacatag  1080
tggggaagt  tttgctgag  gcctaagtg  tagtgcaat  tttgtgcag  gccccaatt  1140
taatcagag  tatggctgg  accctgcaa  agtgtgtaa  attccacca  gctgtaatc  1200
gaagatctt  aacaaccag  aatttgctg  tcttctggc  cagtctgtt  atcagggtt  1260
tgaagccgt  tatcagcta  ctagaatgt  caccataag  atgagtttt  tgaaagggt  1320
gggagcaga  taccgaagg  agacggtaa  aagtactcc  tgctggatt  aacttcatc  1380
gaatggacc  ctacagtgg  tggacaaag  attaactca  atgggatcc  cttcagtgc  1440
ttgctcaag  atgtcataa  gcttcacca  tcaagtccc  tggaaaaga  ttaatgtaa  1500
aactcttct  ttcattagc  ttgtgttgt  gtccctatg  ctgtttact  tccaaaagt  1560
caagagaga  aacagcact  gaggtctca  caattaaag  accttgtgg  atctgtttc  1620
tatatttga  tattagatg  gaaaattag  gtctagaaa  actctccca  taaagagga  1680
gagaagatt  taaagactt  atgatgtct  attgggcat  aaactgagt  tcccaaagg  1740
ttattaata  cagtagtag  tatgtgtac  ggtaatgta  catgatcca  tatcacagt  1800
ttgtgctgt  tatatacat  tttagtttg  atagatgag  tgtgtgtgt  cgctgcttc  1860
tgatctagg  aaaccttta  aaagttgca  tacctaatc  gttattccc  cttctctgt  1920
atttttgtg  gtctttttt  atatataat  tatatcaag  ttttcaaat  atttagaag  1980
agattttcc  gtagaaaaa  taatttttc  gccttttac  aaaaataaa  tcttgggga  2040
g  2041



<210> 7154
<211> 467
<212> PRT
<213> Homo sapiens
<308> Q15796
<400> 7154

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
  1               5                  10                  15
Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
             20                  25                  30
Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
         35                  40                  45
Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
     50                  55                  60
Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Ser Thr 
 65                  70                  75                  80
Cys Ser Glu Ile Trp Gly Leu Ser Thr Pro Asn Thr Ile Asp Gln Trp 
                 85                  90                  95
Asp Thr Thr Gly Leu Tyr Ser Phe Ser Glu Gln Thr Arg Ser Leu Asp 
             100                105                110
Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr 
         115                120                125
Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu Leu Lys 
     130                135                140
Ala Ile Glu Asn Cys Glu Tyr Ala Phe Asn Leu Lys Lys Asp Glu Val 
 145                150                155                160
Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val Leu Pro 
                 165                170                175
Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu Pro Pro 
             180                185                190
Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe Pro Ala 
         195                200                205
Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro Pro Gly 
     210                215                220
Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn Gln Ser 
 225                230                235                240
Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu Ser Pro 
                 245                250                255
Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu Pro Ala 
             260                265                270
Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu 
         275                280                285
Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp 
     290                295                300
Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn 
 305                310                315                320
Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val 
                 325                330                335
Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp 
             340                345                350
Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp 
         355                360                365
His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile 
     370                375                380
Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln 
 385                390                395                400
Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met 
                 405                410                415
Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr 
             420                425                430
Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp 
         435                440                445
Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser 
     450                455                460
Ser Met Ser 
 465



<210> 7155
<211> 495
<212> DNA
<213> Rattus norvegicus
<308> AI228738
<400> 7155

cccaaaaca  agtaacttg  ggtttatgg  atacagttt  ggtcaacac  catacagaa  60
ggggaagag  acatggagg  gtccgaagc  aagctgagt  acggaacac  ttcagttag  120
aggtgtcta  acaaagagt  gtgggacat  aggaaaagc  cccatggat  catgtgcac  180
catctggag  taccagatt  ctccatggc  gatccatgt  cagagctaa  ggaggaggc  240
acttctgtc  ttccagttt  agaagctcc  catcaaaaa  aagagtagc  tgtggtggg  300
tgatgcctg  gtgcccggt  gctccatag  catagtctg  ggagattat  agtttggct  360
tctggccca  actcatctg  gctacccct  cttcccagc  tcggatcac  tcctgcttg  420
ctagtgtaa  cttaaaagg  ttgtttctg  cccgagagg  gtcaaattt  tcccatctt  480
aagcatcca  gtgta  495



<210> 7156
<211> 107
<212> PRT
<213> Rattus norvegicus
<308> Q62658
<400> 7156

Gly Val Gln Val Glu Thr Ile Ser Ser Gly Asp Gly Arg Thr Phe Pro 
  1               5                  10                  15
Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
             20                  25                  30
Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
         35                  40                  45
Thr Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
     50                  55                  60
Gln Met Ser Val Gly Gln Arg Ala Lys Leu Ile Ile Ser Pro Asp Tyr 
 65                  70                  75                  80
Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                 85                  90                  95
Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
             100                105



<210> 7157
<211> 1578
<212> DNA
<213> Homo sapiens
<308> NM_000801
<400> 7157

gcgacgcgc  gaggtacta  gcagagccg  ggaaccgcc  ccaggtcgc  gttggtcca  60
gccgcccgt  gcgccgccc  cccgctcag  gtccgccgc  gccatggga  tgcaggtgg  120
aaccatctc  ccaggagac  ggcgcacct  ccccaagcg  ggccagacc  gcgtggtgc  180
ctacaccgg  atgcttgaa  atggaaaga  atttgattc  tcccgggac  gaaacaagc  240
ctttaagtt  atgctaggc  agcaggagg  gatccgagg  tgggaagaa  gggttgccc  300
gatgagtgt  ggtcagaga  ccaaactga  tatatctcc  gattatgcc  atggtgcca  360
tgggcaccc  ggcatcatc  caccacatg  cactctcgt  ttcgatgtg  agcttctaa  420
actggaatg  caggaatgg  ctcctccct  agctccctg  tcttggatc  gccatggag  480
gatctggtg  ctccagaca  gtgcacatg  gtccatatg  agcttttcc  gatgttcca  540
tccactttg  atagacatc  gccctgact  aatgtgttc  gtcactcag  tttgcttcc  600
acacctctg  ttcctcttc  cctttctcc  cgtatgtgt  tttacctaa  ctatatgcc  660
taaacctca  gttattcat  ttattttgt  ttcattttg  ggtgaagat  cagtttcag  720
cttttggat  taggtttcc  attaagtac  tggtcaagt  ttaacagca  aagtggtag  780
ttaacatta  aataggaat  ggtgttggg  ggggggttt  caagaatat  ttattttaa  840
tttttggat  aaattttta  ctattatat  ttaaacatt  ttgctgctg  gctgcaaag  900
catagcaga  ttgaggcgc  gttgaggac  gaattactc  ccaagttga  agatgtctt  960
gggttaaat  aaaagccct  cctaaaact  aggtgggga  ggggagagc  tttgcctcc  1020
ccattccca  ccaccctcc  cttaaaccc  ctgcctttg  aagtagatc  tgttcactg  1080
aatgctgga  actacaggt  tctgtccct  ggccagcag  gacctctga  gccttcttt  1140
tggcctttt  tttttttca  cctgtggtt  ttctaatgg  ctttcagga  ttttgtaat  1200
tcataactt  ccaagctcc  ccacttcct  aatcttaag  actttaatt  acagtttca  1260
ttgaaggtg  tgtttgtag  cttaacacc  agtgaaagc  cagccatca  gacaaatcc  1320
tgaatgttc  cttaagaaa  tgatgctgg  catcgcagc  tcagcatct  ctgtttttt  1380
atgcttggc  ccctctgct  atctcagtt  cctggcttt  cctccctca  ccccttctc  1440
cccctttgc  gtcctgtgt  gtgatttgg  gagaaatcg  tgctgcacc  ttcccccag  1500
accatttat  agtctcaag  tttattatt  caataaaag  gctttatgc  ggcttttct  1560
aaaaaaaaa  aaaaaaaa  1578



<210> 7158
<211> 107
<212> PRT
<213> Homo sapiens
<308> P20071
<400> 7158

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
  1               5                  10                  15
Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
             20                  25                  30
Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
         35                  40                  45
Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
     50                  55                  60
Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
 65                  70                  75                  80
Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                 85                  90                  95
Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
             100                105



<210> 7159
<211> 444
<212> DNA
<213> Rattus norvegicus
<308> AI229497
<400> 7159

gatggccag  cctgtcatt  tatttcagc  gtggatgaa  caagagttc  ttgtctggt  60
tcttagacg  cagcagtct  cttggcagc  tttctctct  ccagcatcc  ctgcttctg  120
tttgccagg  acttcctgg  agaatagta  gctcccagg  cctggtagc  gtcctggta  180
gctttagac  cttgggtga  ttgctccaa  tccttggca  agttctgca  tgcactctc  240
ccttccctc  gctgacaag  cttaagtct  tcctggatg  tgttgatga  ttcttggtc  300
actttgaag  cccttctcc  ctgcatctc  gcctcatag  tacagatga  atcaccctc  360
ttgcattcc  tgatgtctg  cactcgacg  tactgtcgg  ggtagtagt  ggttcggtt  420
ttggcgtgc  gttgttcaa  gaac  444



<210> 7160
<211> 736
<212> DNA
<213> Homo sapiens
<308> NM_004548
<400> 7160

agccgcctc  gtcctctgt  gcgggcgac  taggccccg  gacccggac  gaggtagag  60
ccagggcag  gcgtccggg  gcggagtcc  cgcccgccg  cgccatgcc  gacagctgg  120
acaaggatg  gtaccctga  cccccgcgc  gcacgccgg  gcagcccaa  cccatcgtc  180
acatgatga  agcgttcga  ctcatcgtg  accgacccg  gaccctcgt  agagaattt  240
tagagcggc  gcacgcaaa  aacaggtat  actactacc  ccggcagta  cgccgcgtg  300
cagacatca  tgagtgcaa  gaggaggac  tcatgtgca  gtatgaagc  gaaatgcag  360
ggaagaggg  ctacaaagt  gaccaagaa  ttatcaaca  tatgcagga  cggctcaaa  420
cctgtcagc  gagggaagg  cagaactac  agcagaact  tatcaagga  gtggagcag  480
tcacccagg  ggccaaggc  taccaggac  gctatcagg  cctgggggc  tacagttct  540
ccaggaagt  cctggccaa  cagaggcag  ggatgctgc  agagagaaa  gctgcaaaa  600
aggccgccg  tgccacctc  tgaggcagc  gtgggtgcc  ctgctgtgt  gctctgtat  660
actgttgct  aaatataaa  ccctgcaac  tgaaaaaaa  aaaaaaaaa  aaaaaaaaa  720
aaaaaaaaa  aaaaaa  736



<210> 7161
<211> 171
<212> PRT
<213> Homo sapiens
<308> O96000
<400> 7161

Pro Asp Ser Trp Asp Lys Asp Val Tyr Pro Glu Pro Pro Arg Arg Thr 
  1               5                  10                  15
Pro Val Gln Pro Asn Pro Ile Val Tyr Met Met Lys Ala Phe Asp Leu 
             20                  25                  30
Ile Val Asp Arg Pro Val Thr Leu Val Arg Glu Phe Ile Glu Arg Gln 
         35                  40                  45
His Ala Lys Asn Arg Tyr Tyr Tyr Tyr His Arg Gln Tyr Arg Arg Val 
     50                  55                  60
Pro Asp Ile Thr Glu Cys Lys Glu Glu Asp Ile Met Cys Met Tyr Glu 
 65                  70                  75                  80
Ala Glu Met Gln Trp Lys Arg Asp Tyr Lys Val Asp Gln Glu Ile Ile 
                 85                  90                  95
Asn Ile Met Gln Asp Arg Leu Lys Ala Cys Gln Gln Arg Glu Gly Gln 
             100                105                110
Asn Tyr Gln Gln Asn Cys Ile Lys Glu Val Glu Gln Phe Thr Gln Val 
         115                120                125
Ala Lys Ala Tyr Gln Asp Arg Tyr Gln Asp Leu Gly Ala Tyr Ser Ser 
     130                135                140
Ala Arg Lys Cys Leu Ala Lys Gln Arg Gln Arg Met Leu Gln Glu Arg 
 145                150                155                160
Lys Ala Ala Lys Glu Ala Ala Ala Ala Thr Ser 
                 165                170



<210> 7162
<211> 444
<212> DNA
<213> Rattus norvegicus
<308> AI229497
<400> 7162

gatggccag  cctgtcatt  tatttcagc  gtggatgaa  caagagttc  ttgtctggt  60
tcttagacg  cagcagtct  cttggcagc  tttctctct  ccagcatcc  ctgcttctg  120
tttgccagg  acttcctgg  agaatagta  gctcccagg  cctggtagc  gtcctggta  180
gctttagac  cttgggtga  ttgctccaa  tccttggca  agttctgca  tgcactctc  240
ccttccctc  gctgacaag  cttaagtct  tcctggatg  tgttgatga  ttcttggtc  300
actttgaag  cccttctcc  ctgcatctc  gcctcatag  tacagatga  atcaccctc  360
ttgcattcc  tgatgtctg  cactcgacg  tactgtcgg  ggtagtagt  ggttcggtt  420
ttggcgtgc  gttgttcaa  gaac  444



<210> 7163
<211> 736
<212> DNA
<213> Homo sapiens
<308> NM_004548
<400> 7163

agccgcctc  gtcctctgt  gcgggcgac  taggccccg  gacccggac  gaggtagag  60
ccagggcag  gcgtccggg  gcggagtcc  cgcccgccg  cgccatgcc  gacagctgg  120
acaaggatg  gtaccctga  cccccgcgc  gcacgccgg  gcagcccaa  cccatcgtc  180
acatgatga  agcgttcga  ctcatcgtg  accgacccg  gaccctcgt  agagaattt  240
tagagcggc  gcacgcaaa  aacaggtat  actactacc  ccggcagta  cgccgcgtg  300
cagacatca  tgagtgcaa  gaggaggac  tcatgtgca  gtatgaagc  gaaatgcag  360
ggaagaggg  ctacaaagt  gaccaagaa  ttatcaaca  tatgcagga  cggctcaaa  420
cctgtcagc  gagggaagg  cagaactac  agcagaact  tatcaagga  gtggagcag  480
tcacccagg  ggccaaggc  taccaggac  gctatcagg  cctgggggc  tacagttct  540
ccaggaagt  cctggccaa  cagaggcag  ggatgctgc  agagagaaa  gctgcaaaa  600
aggccgccg  tgccacctc  tgaggcagc  gtgggtgcc  ctgctgtgt  gctctgtat  660
actgttgct  aaatataaa  ccctgcaac  tgaaaaaaa  aaaaaaaaa  aaaaaaaaa  720
aaaaaaaaa  aaaaaa  736



<210> 7164
<211> 171
<212> PRT
<213> Homo sapiens
<308> O96000
<400> 7164

Pro Asp Ser Trp Asp Lys Asp Val Tyr Pro Glu Pro Pro Arg Arg Thr 
  1               5                  10                  15
Pro Val Gln Pro Asn Pro Ile Val Tyr Met Met Lys Ala Phe Asp Leu 
             20                  25                  30
Ile Val Asp Arg Pro Val Thr Leu Val Arg Glu Phe Ile Glu Arg Gln 
         35                  40                  45
His Ala Lys Asn Arg Tyr Tyr Tyr Tyr His Arg Gln Tyr Arg Arg Val 
     50                  55                  60
Pro Asp Ile Thr Glu Cys Lys Glu Glu Asp Ile Met Cys Met Tyr Glu 
 65                  70                  75                  80
Ala Glu Met Gln Trp Lys Arg Asp Tyr Lys Val Asp Gln Glu Ile Ile 
                 85                  90                  95
Asn Ile Met Gln Asp Arg Leu Lys Ala Cys Gln Gln Arg Glu Gly Gln 
             100                105                110
Asn Tyr Gln Gln Asn Cys Ile Lys Glu Val Glu Gln Phe Thr Gln Val 
         115                120                125
Ala Lys Ala Tyr Gln Asp Arg Tyr Gln Asp Leu Gly Ala Tyr Ser Ser 
     130                135                140
Ala Arg Lys Cys Leu Ala Lys Gln Arg Gln Arg Met Leu Gln Glu Arg 
 145                150                155                160
Lys Ala Ala Lys Glu Ala Ala Ala Ala Thr Ser 
                 165                170



<210> 7165
<211> 568
<212> DNA
<213> Rattus norvegicus
<308> AI229637
<400> 7165

cctagatca  ggcttgttt  ttaaaatat  ggtgaaaaa  taggagtct  tagggctgc  60
gacaggagg  gacatcata  cactcaagg  gtctggact  tcctcctgg  cactctcct  120
ttcctgatc  cactctgta  caggctggg  ctcctgctc  ccagagaca  ccttgctct  180
ttctttggc  gggcagact  ggaggacct  cttttgacc  cctttgtgc  gagagcctt  240
tgatgcttt  tgctttcag  ctctacggg  gacacagga  tggatccat  cacctgtga  300
agcttctct  ttttcttct  cacttttgg  gtcttggca  ggggggtgc  gggactcag  360
gtggggtta  tgggagccg  actcttggc  acagttact  cattcacct  ggatggggt  420
ttagccttc  ctctcttcc  tcttttctt  cctgtgctg  ggggctggt  tttaccagt  480
gcagcaggc  tggcaccct  tgtcactgc  tcctgctgt  atgcagcct  cttttctga  540
gtggtaccc  cagaattaa  tttctttc  568



<210> 7166
<211> 1277
<212> PRT
<213> Rattus norvegicus
<308> NP_113856
<400> 7166

Met Lys Tyr Ala Leu Lys Arg Leu Ile Thr Gly Leu Gly Val Gly Arg 
  1               5                  10                  15
Glu Ala Ala Arg Pro Cys Tyr Ser Leu Ala Leu Ala Gln Leu Leu Gln 
             20                  25                  30
Ser Phe Glu Asp Ile Gln Leu Cys Asp Ile Leu Gly Gln Ile Gln Glu 
         35                  40                  45
Lys Tyr Asn Leu Gln Ala Met Asn Lys Ala Met Met Arg Pro Thr Leu 
     50                  55                  60
Phe Ala Asn Leu Phe Ala Val Leu Ala Leu Phe Gln Ser Gly Arg Leu 
 65                  70                  75                  80
Val Lys Asp Lys Glu Ala Leu Met Lys Cys Val Arg Leu Leu Lys Ile 
                 85                  90                  95
Leu Ser His His Tyr Asn His Leu Gln Gly Gln Pro Val Lys Ala Leu 
             100                105                110
Val Asp Ile Leu Ser Glu Val Pro Glu Ser Met Phe Gln Glu Ile Leu 
         115                120                125
Pro Lys Val Leu Lys Gly Asp Met Lys Val Ile Leu Ser Ser Pro Lys 
     130                135                140
Tyr Leu Glu Leu Phe Leu Leu Ala Arg Gln Arg Val Pro Ala Glu Leu 
 145                150                155                160
Glu Ser Leu Val Gly Ser Val Asp Leu Phe Ser Glu Asp Asn Ile Pro 
                 165                170                175
Ser Leu Val Asn Ile Leu Lys Val Ala Ala Asn Ser Val Lys Lys Glu 
             180                185                190
Gln Lys Leu Pro Asp Val Ala Leu Asn Leu Leu Arg Leu Ala Leu Gln 
         195                200                205
Glu Asn Lys Phe Glu Arg Phe Trp Lys Glu Val Leu Glu Glu Gly Leu 
     210                215                220
Leu Lys Lys Pro Ser Tyr Thr Ser Ser Tyr Met Cys Phe Arg Leu Leu 
 225                230                235                240
Gly Ala Ser Leu Pro Leu Leu Ser Asp Glu Gln Leu Gln Leu Val Met 
                 245                250                255
Arg Gly Asp Leu Ile Arg His Phe Gly Glu His Met Val Val Ser Lys 
             260                265                270
Ser Gln Asn Pro Leu Arg Phe Ile Pro Glu Ile Ser Ala Tyr Val Gly 
         275                280                285
Thr Phe Leu Glu Gly Cys Gln Asp Asp Pro Lys Arg Gln Phe Thr Val 
     290                295                300
Met Val Ala Phe Thr Ala Ile Thr Asn Gln Gly Leu Pro Val Met Pro 
 305                310                315                320
Thr Phe Trp Arg Val Thr Arg Phe Leu Asn Thr Glu Ala Leu Gln Asn 
                 325                330                335
Tyr Val Thr Trp Leu Arg Asp Met Phe Leu Gln Pro Asp Leu Asp Ser 
             340                345                350
Leu Val Asp Phe Ser Thr Ala Asn Gln Lys Arg Val Gln Asp Ala Ser 
         355                360                365
Leu Asn Val Pro Glu Arg Thr Val Phe Arg Leu Arg Lys Trp Ile Ile 
     370                375                380
His Arg Leu Val Ser Leu Val Asp His Leu His Leu Glu Lys Asp Glu 
 385                390                395                400
Ala Val Val Glu Gln Ile Ala Arg Phe Cys Leu Phe His Ala Phe Phe 
                 405                410                415
Lys Thr Lys Lys Ala Thr Pro Gln Ile Pro Glu Thr Lys Gln His Phe 
             420                425                430
Ser Phe Pro Leu Glu Asp Gly Asn Arg Gly Val Ile Val Ser Ala Phe 
         435                440                445
Phe Ser Leu Leu Gln Thr Leu Ser Val Lys Phe Arg Gln Thr Pro Asp 
     450                455                460
Leu Ala Glu Asn Gly Lys Pro Trp Thr Tyr Arg Leu Val Gln Leu Ala 
 465                470                475                480
Asp Met Leu Leu Lys His Asn Arg Asn Val Ala Asn Val Thr Pro Leu 
                 485                490                495
Thr Ala Gln Gln Arg Gln Ala Trp Asp Gln Met Met Ser Thr Leu Lys 
             500                505                510
Glu Leu Glu Ala Gln Ser Ser Glu Thr Arg Ala Ile Ala Phe Gln His 
         515                520                525
Leu Leu Leu Leu Val Gly Leu His Leu Phe Lys Ser Pro Ala Glu Ser 
     530                535                540
Cys Asp Val Leu Gly Asp Ile Gln Thr Cys Ile Lys Lys Ser Met Glu 
 545                550                555                560
Gln Asn Leu Arg Arg Ser Arg Ser Arg Ala Lys Ala Ser Gln Glu Pro 
                 565                570                575
Val Trp Val Glu Val Met Val Glu Ile Leu Leu Ser Leu Leu Ala Gln 
             580                585                590
Pro Ser Asn Leu Met Arg Gln Val Val Arg Ser Val Phe Gly His Val 
         595                600                605
Cys Ser His Leu Thr Pro Arg Gly Leu Gln Leu Ile Leu Ala Val Leu 
     610                615                620
Asn Pro Glu Thr Asn Glu Asp Glu Glu Asp Asn Val Val Val Thr Asp 
 625                630                635                640
Thr Asp Glu Lys Gln Leu Lys His Gly Glu Asp Ala Asp Ser Asp Ser 
                 645                650                655
Glu Asp Ser Lys Asn Ser Glu Ser Asp Val Asp Ser Glu Asp Gly Glu 
             660                665                670
Glu Ser Glu Glu Glu Asp Arg Asp Lys Asp Val Asp Pro Gly Phe Arg 
         675                680                685
Gln Gln Leu Met Glu Val Leu Gln Ala Gly Asn Ala Leu Gly Gly Glu 
     690                695                700
Glu Glu Glu Glu Glu Glu Leu Gly Asp Glu Ala Met Met Ala Leu Asp 
 705                710                715                720
Gln Asn Leu Ala Ser Leu Phe Ala Glu Gln Lys Met Arg Ile Gln Ala 
                 725                730                735
Arg His Glu Glu Lys Asn Lys Leu Gln Lys Glu Lys Gln Leu Arg Arg 
             740                745                750
Asp Phe Gln Ile Arg Ala Leu Asp Leu Ile Glu Val Leu Val Thr Lys 
         755                760                765
Gln Pro Glu His Pro Leu Ile Leu Glu Leu Leu Glu Pro Leu Leu Asn 
     770                775                780
Ile Ile Gln Arg Ser Met Arg Ser Arg Gly Ser Thr Lys Gln Glu Gln 
 785                790                795                800
Asp Leu Leu His Lys Thr Ala Arg Ile Phe Met His His Leu Cys Arg 
                 805                810                815
Ala Arg His Tyr Cys His Glu Val Glu Pro Gly Ala Glu Ala Leu His 
             820                825                830
Ala Gln Val Glu Arg Phe Val Gln Gln Ala Gly Asn Gln Ala Asp Ala 
         835                840                845
Ser Val Ala Leu Tyr Tyr Phe Asn Ala Ser Leu Tyr Leu Leu Arg Val 
     850                855                860
Leu Lys Gly Asn Thr Thr Lys Arg Tyr Gln Asp Gly Gln Lys Leu Glu 
 865                870                875                880
Gly Ala Asp Ile Lys Ser Glu Pro Lys Asp Ser Glu Val Gln Thr Thr 
                 885                890                895
Ser Cys Leu Asp Leu Asp Phe Val Thr Arg Val Tyr Ser Ala Ser Leu 
             900                905                910
Glu Ser Leu Leu Thr Lys Arg Asn Ser Pro Leu Thr Ile Pro Met Phe 
         915                920                925
Leu Asp Leu Phe Ser Arg Tyr Pro Val Ile Cys Lys Asn Leu Leu Pro 
     930                935                940
Ile Val Val Gln His Val Ala Gly Ser Ser Arg Pro Arg His Gln Ala 
 945                950                955                960
Gln Ala Cys Leu Leu Leu Gln Lys Ala Leu Ser Ala Arg Glu Leu Arg 
                 965                970                975
Val Cys Phe Glu Asp Pro Glu Trp Glu Gln Leu Ile Ser Gln Val Leu 
             980                985                990
Gly Lys Thr Thr Gln Thr Leu Gln Thr Leu Gly Glu Ala Gln Ser Lys 
         995                1000                1005
Gly Glu His Gln Arg Glu Leu Ser Ile Leu Glu Leu Leu Asn Thr Val 
     1010                1015                1020
Phe Arg Ile Val Asn His Glu Lys Leu Ser Val Asp Leu Thr Ala Phe 
 1025                1030                1035                1040
Leu Gly Met Leu Gln Gly Lys Gln Gln Lys Leu Gln Gln Asn Leu Gln 
                 1045                1050                1055
Gln Gly Asn His Ser Ser Gly Ser Ser Arg Leu Tyr Asp Leu Tyr Trp 
             1060                1065                1070
Gln Ala Met Asn Leu Leu Gly Val Gln Arg Pro Lys Ser Glu Lys Lys 
         1075                1080                1085
Asn Val Lys Asp Ile Pro Ser Asp Ser Gln Ser Pro Ile Ser Thr Lys 
     1090                1095                1100
Arg Lys Lys Lys Gly Phe Leu Pro Glu Thr Lys Lys Arg Lys Lys Leu 
 1105                1110                1115                1120
Lys Ser Glu Gly Thr Thr Ser Glu Lys Lys Ala Ala Ser Gln Gln Asp 
                 1125                1130                1135
Arg Val Thr Glu Gly Ala Met Pro Ala Ala Thr Gly Lys Asp Gln Pro 
             1140                1145                1150
Pro Ser Thr Gly Lys Lys Arg Arg Lys Arg Val Lys Ala Asn Thr Pro 
         1155                1160                1165
Ser Gln Val Asn Gly Val Thr Val Ala Lys Ser Pro Ala Pro Asn Asn 
     1170                1175                1180
Pro Thr Leu Ser Pro Ser Thr Pro Pro Ala Lys Thr Pro Lys Val Gln 
 1185                1190                1195                1200
Lys Lys Lys Glu Lys Leu Ser Gln Val Asn Gly Ser Thr Pro Val Ser 
                 1205                1210                1215
Pro Val Glu Pro Glu Ser Lys Lys His Gln Lys Ala Leu Ser Thr Lys 
             1220                1225                1230
Glu Val Lys Arg Arg Ser Ser Gln Ser Ala Leu Pro Lys Lys Arg Ala 
         1235                1240                1245
Arg Leu Ser Leu Val Ser Arg Ser Pro Ser Leu Leu Gln Ser Gly Ile 
     1250                1255                1260
Arg Lys Arg Arg Val Ala Arg Arg Arg Val Gln Thr Pro 
 1265                1270                1275



<210> 7167
<211> 489
<212> DNA
<213> Rattus norvegicus
<308> AI229924
<400> 7167

ggccagcgg  ctgcgccag  ctgcttctg  agccagtac  tcggtgaag  ccattttca  60
tcgggacct  aaagaggcc  agcggaggg  gcgcgagct  taccgcgct  ggtaccggg  120
ggtgccaaa  actgtgcac  taatgcagc  ggatatcac  gtgaaacaa  gacgggata  180
agtccgaga  atgttcatg  agaatgccc  tgtcaccga  cccagagtg  ttgacctcc  240
ggtcattaa  ggaaagatg  agctccagg  aaccattaa  gtgtggaag  agcggacac  300
cattatgcg  ttcttccat  aaacagaaa  accaaggcc  aaagatttc  tgtccaagt  360
ctatattgg  catgaccca  gaggtcacc  gatgggaag  tgcatgtta  tatttaatt  420
tcttagagt  caaataaac  cattatttg  tggtcgtga  aaagttgca  tggtgaacc  480
cctcgtgcc  489



<210> 7168
<211> 131
<212> PRT
<213> Rattus norvegicus
<308> NP_080263
<400> 7168

Met Ala Ala Ala Ala Thr Gly Leu Arg Gln Ala Ala Ala Ala Ala Ala 
  1               5                  10                  15
Ser Thr Ser Val Lys Pro Ile Phe Ser Arg Asp Leu Asn Glu Ala Lys 
             20                  25                  30
Arg Arg Val Arg Glu Leu Tyr Arg Ala Trp Tyr Arg Glu Val Pro Asn 
         35                  40                  45
Thr Val His Leu Met Gln Leu Asp Ile Thr Val Lys Gln Gly Arg Asp 
     50                  55                  60
Lys Val Arg Glu Met Phe Met Lys Asn Ala His Val Thr Asp Pro Arg 
 65                  70                  75                  80
Val Val Asp Leu Leu Val Ile Lys Gly Lys Met Glu Leu Gln Glu Thr 
                 85                  90                  95
Ile Lys Val Trp Lys Gln Arg Thr His Val Met Arg Phe Phe His Glu 
             100                105                110
Thr Glu Thr Pro Arg Pro Lys Asp Phe Leu Ser Lys Phe Tyr Met Gly 
         115                120                125
His Asp Pro 
     130



<210> 7169
<211> 573
<212> DNA
<213> Rattus norvegicus
<308> AI230211
<400> 7169

ttcatcacc  atgctaagt  aggttgaat  gagtggtgg  gtggggaat  tactgatac  60
ctaacatgg  ttgtacacc  tgagtcatt  catcagaga  ctcttggtc  ccagaagaa  120
gtggtatcc  ggttgttgc  ttactagct  atgaatcag  tttactaag  tgatcgaag  180
tttgccgct  tgcttcccc  tgaatcccc  ttagcagat  tggctgtga  ctgttttct  240
gggttggta  ctttgagca  aggtgagtt  ggttcctta  ctcttgtca  gactaaaat  300
ggggaatga  aatgcagac  gtttaatga  tatttttag  agctggcat  atatgggct  360
tggagatga  atagaaaca  cacaagatt  aggtctctg  agtcaataa  aatggaatt  420
tggaggtgc  ggttttaaa  tatatttct  ttcatgaga  gcacagtat  ctgcgttgg  480
gcactgttc  agtgacatg  agatccttg  ttgaagcag  cattattct  actctctaa  540
gacttgttc  gaaataaaa  cgtggtttg  atg  573



<210> 7170
<211> 611
<212> PRT
<213> Rattus norvegicus
<308> AAA80459
<400> 7170

Met Ala Ala Gly Val Ala Ala Trp Leu Pro Phe Ala Arg Ala Ala Ala 
  1               5                  10                  15
Ile Gly Trp Met Pro Val Ala Asn Cys Pro Met Pro Leu Ala Pro Ala 
             20                  25                  30
Asp Lys Asn Lys Arg Gln Asp Glu Leu Ile Val Leu Asn Val Ser Gly 
         35                  40                  45
Arg Arg Phe Gln Thr Trp Arg Thr Thr Leu Glu Arg Tyr Pro Asp Thr 
     50                  55                  60
Leu Leu Gly Ser Thr Glu Lys Glu Phe Phe Phe Asn Glu Asp Thr Lys 
 65                  70                  75                  80
Glu Tyr Phe Phe Asp Arg Asp Pro Glu Val Phe Arg Cys Val Leu Asn 
                 85                  90                  95
Phe Tyr Arg Thr Gly Lys Leu His Tyr Pro Arg Tyr Glu Cys Ile Ser 
             100                105                110
Ala Tyr Asp Asp Glu Leu Ala Phe Tyr Gly Ile His Pro Glu Ile Ile 
         115                120                125
Gly Asp Cys Cys Tyr Glu Glu Tyr Lys Asp Arg Lys Arg Glu Asn Ala 
     130                135                140
Glu Arg Leu Met Asp Asp Asn Glu Ser Glu Asn Asn Gln Glu Ser Met 
 145                150                155                160
Pro Ser Leu Ser Phe Arg Gln Thr Met Trp Arg Ala Phe Glu Asn Pro 
                 165                170                175
His Thr Ser Thr Leu Ala Leu Val Phe Tyr Tyr Val Thr Gly Phe Phe 
             180                185                190
Ile Ala Val Ser Val Ile Thr Asn Val Val Glu Thr Val Pro Cys Gly 
         195                200                205
Thr Val Pro Gly Ser Lys Glu Leu Pro Cys Gly Glu Arg Tyr Ser Val 
     210                215                220
Ala Phe Phe Cys Leu Asp Thr Ala Cys Val Met Ile Phe Thr Val Glu 
 225                230                235                240
Tyr Leu Leu Arg Leu Phe Ala Ala Pro Ser Arg Tyr Arg Phe Ile Arg 
                 245                250                255
Ser Val Met Ser Ile Ile Asp Val Val Ala Ile Met Pro Tyr Tyr Ile 
             260                265                270
Gly Leu Val Met Thr Asn Asn Glu Asp Val Ser Gly Ala Phe Val Thr 
         275                280                285
Leu Arg Val Phe Arg Val Phe Arg Ile Phe Lys Phe Ser Arg His Ser 
     290                295                300
Gln Gly Leu Arg Ile Leu Gly Tyr Thr Leu Lys Ser Cys Ala Ser Glu 
 305                310                315                320
Leu Gly Phe Leu Leu Phe Ser Leu Thr Met Ala Ile Ile Ile Phe Ala 
                 325                330                335
Thr Val Met Phe Tyr Ala Glu Lys Gly Ser Ser Ala Ser Lys Phe Thr 
             340                345                350
Ser Ile Pro Ala Ser Phe Trp Tyr Thr Ile Val Thr Met Thr Thr Leu 
         355                360                365
Gly Tyr Gly Asp Met Val Pro Lys Thr Ile Ala Gly Lys Ile Phe Gly 
     370                375                380
Ser Ile Cys Ser Leu Ser Gly Val Leu Val Ile Ala Leu Pro Val Pro 
 385                390                395                400
Val Ile Val Ser Asn Phe Ser Arg Ile Tyr His Gln Asn Gln Arg Ala 
                 405                410                415
Asp Lys Arg Arg Ala Gln Lys Lys Ala Arg Leu Ala Arg Ile Arg Val 
             420                425                430
Ala Lys Thr Gly Ser Ser Asn Ala Tyr Leu His Ser Lys Arg Asn Gly 
         435                440                445
Leu Leu Asn Glu Ala Leu Glu Leu Thr Gly Thr Pro Glu Glu Glu His 
     450                455                460
Met Gly Lys Thr Thr Ser Leu Ile Glu Ser Gln His His His Leu Leu 
 465                470                475                480
His Cys Leu Glu Lys Thr Thr Asn His Glu Phe Ile Asp Glu Gln Met 
                 485                490                495
Phe Glu Gln Asn Cys Met Glu Ser Ser Met Gln Asn Tyr Pro Ser Thr 
             500                505                510
Arg Ser Pro Ser Leu Ser Ser His Ser Gly Leu Thr Thr Thr Cys Cys 
         515                520                525
Ser Arg Arg Ser Lys Lys Thr Thr His Leu Pro Asn Ser Asn Leu Pro 
     530                535                540
Ala Thr Arg Leu Arg Thr Met Gln Glu Leu Ser Thr Ile His Ile Gln 
 545                550                555                560
Gly Ser Glu Gln Pro Ser Leu Thr Thr Ser Arg Ser Ser Leu Asn Leu 
                 565                570                575
Lys Ala Asp Asp Gly Leu Arg Pro Asn Cys Lys Thr Gln Asp Gln Glu 
             580                585                590
Gln Pro Arg Gly Arg Val Val Thr Cys Lys Gln Glu Glu Ile Ile Thr 
         595                600                605
Leu Cys Ile 
     610



<210> 7171
<211> 4723
<212> DNA
<213> Homo sapiens
<308> AB040902
<400> 7171

gcaggacaa  ctcagcctg  agctgccgt  ggctttgtg  ggactggac  cagagcttg  60
gagacgggg  agggctatt  ctccaattc  ctgtcaatg  aattacagc  atagcggca  120
tgtatatag  attgctttt  ctcgtcttc  tgggttctg  agtaacgga  gctaccttg  180
ataaagacc  caacactgc  gaccatgat  agcgcagcc  ggagcatct  cctcatcgg  240
actaaaatt  ggctgttcc  tcaagtagc  cctctatca  ttatggcta  atcctgtcc  300
tctgtgtgt  gctgcgatg  gggtttcat  tactgtaat  atcgctttc  gacatccat  360
ccaacagga  taccagagg  tgctacaac  ctctacctt  agaacaacc  aataaataa  420
gctgggatt  cttcagatt  gaaaaactt  ctgaaagta  aaagaatat  cctatacca  480
aacagttta  atgaatttc  taccaacct  ccaaagtat  taaaagagt  acatttgca  540
gaaaataac  taaggacta  cacttatga  tcactttca  aaattccct  tctggaaga  600
ttacattta  atgacaact  tgtctctgc  gttagcata  aagagggag  attccgaga  660
agcaactat  tccgactgc  tttcctgtc  cgtaatcac  ttagcacaa  tccctgggg  720
ttgcccagg  ctatagaag  actacgctt  gatgataat  gcatatcca  tatttcatc  780
ccatctctt  aaggtctca  tagtctaaa  cgcctggtt  tagatggaa  cctgttgaa  840
aatcatggt  taggtgaca  agttttctt  aacctagtt  atttgacag  gctgtccct  900
gtgcggaat  ccctgactg  tgcaccagt  aaccttcca  gcacaaacc  gaggaagct  960
tatcttcaa  ataaccaca  caatcgggt  cccccaaat  ctttttctt  tctaaggca  1020
ctctatcga  tggatatgt  caataataa  ctaagtaat  tacctcagg  tatctttga  1080
gatttggac  atataacac  actgattct  cgcaacaat  cctggtatt  cgggtgcaa  1140
atgaaatgg  tacgtgact  gttacaatc  ctacctgtg  aggtcaacg  gcgtgggct  1200
atgtgccaa  ccccagaaa  ggttcgtgg  atggctatt  aggatctca  tgcagaact  1260
tttgattgt  aggacagtg  gattgtaag  accattcag  taaccactg  aatacccaa  1320
acagtgtat  ctgcccaag  acagtggcc  gctccagtg  ccaaacagc  agatattaa  1380
aaccccaag  tcactaagg  tcaccaaac  acagggagt  cctcaagaa  aacaattac  1440
attactgtg  agtctgtca  ttctgatac  attcatatc  cttggaaac  tgctctacc  1500
atgactgct  tgagactca  ctggcttaa  ctgggccat  gcccggcat  tggatctat  1560
acagaaaca  ttgtaacag  ggaacgcag  gagtacttg  tcacagccc  ggagcctga  1620
tcaccctat  aagtatgca  ggttcccat  gaaaccagc  acctctacc  atttgatga  1680
actcctgtt  gtattgaga  tgaaactgc  ccccttcga  tgtacaacc  tacaaccac  1740
ctcaatcga  agcaagaga  agaacctta  aaaaacccc  atttacctt  ggctgccat  1800
attggtggg  ctgtggccc  ggttaccat  gcccttctt  ctttagtgt  ttggtatgt  1860
cataggaat  gatcgctct  ctcaaggaa  tgtgcatat  gcaaaggga  gagaagaaa  1920
gatgactat  cagaagctg  cactaagaa  gacaactct  tcctggaaa  cagggaaac  1980
tcttttcag  tgttaccaa  aagcaatga  cccatctcg  aggaggagt  tgtaataca  2040
accatattt  ctcctaatg  aatgaatct  tacaaaaac  atcacagtg  aagcagtag  2100
aaccgaagc  acagagaca  tggtattcc  gactcagat  actcacact  atgatgctg  2160
aggactcac  gcagacttg  gttttgggt  ttttaaacc  aagggaggt  atggtagga  2220
ccctgttct  ctgcaaaac  ctggaaaaa  agactgaaa  aaagcaatg  actgtacat  2280
tgccatata  tttatattt  agaactttt  attaaaagt  tcaaatttc  ggttactgc  2340
gcgattgat  tagtggaga  gcctgaaca  aattctata  tttagtatt  tttagtaat  2400
tgtactgta  tttccttgc  aatattgga  ttataaacc  tttactttg  gttctactg  2460
gtaagatga  ttgttgact  tgaaagtga  ttttcttgc  gtgtcgaac  atcaggact  2520
cattcatat  agatccttg  agtataagc  caggccatt  ttcactttg  tattaataa  2580
atgtaaaaa  aaaaaactg  ctgaatggc  gaatgagat  aaatttaat  ttaaaaaat  2640
gttatgaaa  aatgttcca  ttattaaat  tgtattatc  cagtggtat  caataaatc  2700
aaatgtgtg  agtaatggg  aatatcaaa  ttcctgcat  tctccattt  tgctctagg  2760
aaattaatt  tccttaaaa  agttaagca  atcttctga  ctgaataca  cagctggca  2820
aaaaggagc  tgaagtctg  taaagccat  gtcagcaaa  ctttgaaaa  aaaggactt  2880
acaaaaacg  taatgtaaa  gtgcttcca  gttgggggg  aaatgtgta  ttaggaaaa  2940
atggaaact  agacttgta  agtgtaatg  acacaaata  caaaactgc  ttttggttt  3000
gcctatacc  tcctgattt  tgaaaagtg  attataaac  caaaattgt  agtgtttat  3060
atgttttta  cataaagga  gtcagagaa  ctttatgca  attaaaaat  taatgtaat  3120
ataagcgat  cccctcaac  atccagaga  agtagttct  taaataaga  ataatttaa  3180
gaaaaataa  tactagaca  caaatttag  tctggttta  gtcaaaggt  ttaacactg  3240
acataaatg  tcaatttac  tttacaaag  tcaagaata  tgcccatta  tgtcacaat  3300
ttccagata  tatataatg  actcgtaat  taacatttc  ttctagctt  ctactgaat  3360
gtgagctgt  acttgttga  aaaccatat  acttttctg  tgccatgat  ttttttttt  3420
caacaaaaa  ccaaagtgc  ttgtacgcc  tttggccag  cttgtatgt  ccttgatcc  3480
acgctacat  tattcagct  ttaaaactc  acaaatttt  catactcct  aaatatgaa  3540
aattatggt  ttattgctg  ataaaactt  taaaaagta  agaataatt  tgcttgctt  3600
ttcaggatt  tgttactat  actaagtag  aaattgccc  gcacattag  cctaaacgt  3660
ccatgtatt  ttctaggca  aaaaataaa  gttggctaa  aattttaaa  aatcaacat  3720
ttgaggttg  gtatcattt  acttcaaag  gttcagtgt  tcatgtata  atgtatttc  3780
tcttactta  acactgtat  gatggaaaa  ttaagaaat  gtttcaaag  ctttctctc  3840
taggcgcac  gctgccact  tcctgatac  ttttaaggt  gtctttgaa  aactgtttt  3900
ttaaaatag  cttttagta  agtgagttg  catttgtga  actgtgaaa  acacacttt  3960
tctttgtcc  tgtttctgg  atacaactc  taaaatcct  gcaatcttc  aagtgatat  4020
ttttcatat  ctaatgagt  cactgatag  tggcaggcc  taggtagct  caagataaa  4080
tctgatcat  gaaaagacc  agacatgat  atagggttg  gacttacaa  cccaaaccc  4140
aacctccag  gagggcgaa  tggatgaag  ttaagttga  caccagtga  cagtggttt  4200
atcaagcat  cctatgtaa  caagcctcc  taaaaaaac  aaaggtcaa  atttggaga  4260
cttccagat  gctgaacat  tggtggttc  tgcaggatg  catgcctgg  gagggcatg  4320
aagctctgt  cccacctag  cctcacctt  tgtttcctg  catctggat  ctttgtaac  4380
tcctttata  tacgtcagt  aatctgttt  cttgcattt  gtgagctgt  gtagcaaat  4440
aatagaaca  aaaaagggg  tcctgggaa  ccaaacttg  agctgacta  tcttgcaac  4500
ggtgtctga  gaggaggca  ttttgtggg  ataagccct  aacctgtgg  atatgacac  4560
atttccagg  agacagtgt  gggattaaa  tgaattgga  gacacccag  tggtatctg  4620
tgaagaact  attgcttgc  tggtgtatg  ggcaaaact  gttaagaca  gtcttctat  4680
ttgattatt  ttgaatgag  gaattaaac  cacatacac  ctt  4723



<210> 7172
<211> 649
<212> PRT
<213> Homo sapiens
<308> Q9NZU0
<400> 7172

Met Ile Ser Ala Ala Trp Ser Ile Phe Leu Ile Gly Thr Lys Ile Gly 
  1               5                  10                  15
Leu Phe Leu Gln Val Ala Pro Leu Ser Val Met Ala Lys Ser Cys Pro 
             20                  25                  30
Ser Val Cys Arg Cys Asp Ala Gly Phe Ile Tyr Cys Asn Asp Arg Phe 
         35                  40                  45
Leu Thr Ser Ile Pro Thr Gly Ile Pro Glu Asp Ala Thr Thr Leu Tyr 
     50                  55                  60
Leu Gln Asn Asn Gln Ile Asn Asn Ala Gly Ile Pro Ser Asp Leu Lys 
 65                  70                  75                  80
Asn Leu Leu Lys Val Glu Arg Ile Tyr Leu Tyr His Asn Ser Leu Asp 
                 85                  90                  95
Glu Phe Pro Thr Asn Leu Pro Lys Tyr Val Lys Glu Leu His Leu Gln 
             100                105                110
Glu Asn Asn Ile Arg Thr Ile Thr Tyr Asp Ser Leu Ser Lys Ile Pro 
         115                120                125
Tyr Leu Glu Glu Leu His Leu Asp Asp Asn Ser Val Ser Ala Val Ser 
     130                135                140
Ile Glu Glu Gly Ala Phe Arg Asp Ser Asn Tyr Leu Arg Leu Leu Phe 
 145                150                155                160
Leu Ser Arg Asn His Leu Ser Thr Ile Pro Trp Gly Leu Pro Arg Thr 
                 165                170                175
Ile Glu Glu Leu Arg Leu Asp Asp Asn Arg Ile Ser Thr Ile Ser Ser 
             180                185                190
Pro Ser Leu Gln Gly Leu Thr Ser Leu Lys Arg Leu Val Leu Asp Gly 
         195                200                205
Asn Leu Leu Asn Asn His Gly Leu Gly Asp Lys Val Phe Phe Asn Leu 
     210                215                220
Val Asn Leu Thr Glu Leu Ser Leu Val Arg Asn Ser Leu Thr Ala Ala 
 225                230                235                240
Pro Val Asn Leu Pro Gly Thr Asn Leu Arg Lys Leu Tyr Leu Gln Asp 
                 245                250                255
Asn His Ile Asn Arg Val Pro Pro Asn Ala Phe Ser Tyr Leu Arg Gln 
             260                265                270
Leu Tyr Arg Leu Asp Met Ser Asn Asn Asn Leu Ser Asn Leu Pro Gln 
         275                280                285
Gly Ile Phe Asp Asp Leu Asp Asn Ile Thr Gln Leu Ile Leu Arg Asn 
     290                295                300
Asn Pro Trp Tyr Cys Gly Cys Lys Met Lys Trp Val Arg Asp Trp Leu 
 305                310                315                320
Gln Ser Leu Pro Val Lys Val Asn Val Arg Gly Leu Met Cys Gln Ala 
                 325                330                335
Pro Glu Lys Val Arg Gly Met Ala Ile Lys Asp Leu Asn Ala Glu Leu 
             340                345                350
Phe Asp Cys Lys Asp Ser Gly Ile Val Ser Thr Ile Gln Ile Thr Thr 
         355                360                365
Ala Ile Pro Asn Thr Val Tyr Pro Ala Gln Gly Gln Trp Pro Ala Pro 
     370                375                380
Val Thr Lys Gln Pro Asp Ile Lys Asn Pro Lys Leu Thr Lys Asp His 
 385                390                395                400
Gln Thr Thr Gly Ser Pro Ser Arg Lys Thr Ile Thr Ile Thr Val Lys 
                 405                410                415
Ser Val Thr Ser Asp Thr Ile His Ile Ser Trp Lys Leu Ala Leu Pro 
             420                425                430
Met Thr Ala Leu Arg Leu Ser Trp Leu Lys Leu Gly His Ser Pro Ala 
         435                440                445
Phe Gly Ser Ile Thr Glu Thr Ile Val Thr Gly Glu Arg Ser Glu Tyr 
     450                455                460
Leu Val Thr Ala Leu Glu Pro Asp Ser Pro Tyr Lys Val Cys Met Val 
 465                470                475                480
Pro Met Glu Thr Ser Asn Leu Tyr Leu Phe Asp Glu Thr Pro Val Cys 
                 485                490                495
Ile Glu Thr Glu Thr Ala Pro Leu Arg Met Tyr Asn Pro Thr Thr Thr 
             500                505                510
Leu Asn Arg Glu Gln Glu Lys Glu Pro Tyr Lys Asn Pro Asn Leu Pro 
         515                520                525
Leu Ala Ala Ile Ile Gly Gly Ala Val Ala Leu Val Thr Ile Ala Leu 
     530                535                540
Leu Ala Leu Val Cys Trp Tyr Val His Arg Asn Gly Ser Leu Phe Ser 
 545                550                555                560
Arg Asn Cys Ala Tyr Ser Lys Gly Arg Arg Arg Lys Asp Asp Tyr Ala 
                 565                570                575
Glu Ala Gly Thr Lys Lys Asp Asn Ser Ile Leu Glu Ile Arg Glu Thr 
             580                585                590
Ser Phe Gln Met Leu Pro Ile Ser Asn Glu Pro Ile Ser Lys Glu Glu 
         595                600                605
Phe Val Ile His Thr Ile Phe Pro Pro Asn Gly Met Asn Leu Tyr Lys 
     610                615                620
Asn Asn His Ser Glu Ser Ser Ser Asn Arg Ser Tyr Arg Asp Ser Gly 
 625                630                635                640
Ile Pro Asp Ser Asp His Ser His Ser 
                 645



<210> 7173
<211> 520
<212> DNA
<213> Rattus norvegicus
<308> AI230354
<400> 7173

attccacct  ataacgcat  agggatggt  tcttctctg  aagggtact  gatggactc  60
tcagtacag  acactcctc  ttggaaggg  gtatgcctt  aagtaagaa  tataaaaag  120
caatccagc  agcaacacg  aaatcacat  gaggaccac  tacggcagc  gcgtcttgt  180
gaacatggt  acgggctgg  cgatgtcac  accaggtgc  ggcggcggt  ggaagagac  240
gcggcggtc  agataccca  ttcccagga  ccccgccct  gggatggcg  cagccccaa  300
cgaccgtac  cctcctaga  tgaaagcag  agcgacctg  gcagtttgg  ctcggccgc  360
ccgccacca  gagcaaccg  gccccagac  ttcccttca  ggtcccctc  cagggcccg  420
actcccggc  agttgccgc  gctctgtcg  ctcaggcgc  tgctctcag  gctggctag  480
cgcggccaa  cgccctccg  tgccctgtg  ccctcgttcc  520



<210> 7174
<211> 283
<212> PRT
<213> Rattus norvegicus
<308> BAA12335
<400> 7174

Met Phe Asp Lys Thr Arg Leu Pro Tyr Val Ala Leu Asp Val Ile Cys 
  1               5                  10                  15
Val Leu Leu Ala Gly Leu Pro Phe Ala Ile Leu Thr Ser Arg His Thr 
             20                  25                  30
Pro Phe Gln Arg Gly Ile Phe Cys Asn Asp Asp Ser Ile Lys Tyr Pro 
         35                  40                  45
Tyr Lys Glu Asp Thr Ile Pro Tyr Ala Leu Leu Gly Gly Ile Val Ile 
     50                  55                  60
Pro Phe Cys Ile Ile Val Met Ser Ile Gly Glu Ser Leu Ser Val Tyr 
 65                  70                  75                  80
Phe Asn Val Leu His Ser Asn Ser Phe Val Gly Asn Pro Tyr Ile Ala 
                 85                  90                  95
Thr Ile Tyr Lys Ala Val Gly Ala Phe Leu Phe Gly Val Ser Ala Ser 
             100                105                110
Gln Ser Leu Thr Asp Ile Ala Lys Tyr Thr Ile Gly Ser Leu Arg Pro 
         115                120                125
His Phe Leu Ala Ile Cys Asn Pro Asp Trp Ser Lys Ile Asn Cys Ser 
     130                135                140
Asp Gly Tyr Ile Glu Asp Tyr Ile Cys Gln Gly Asn Glu Glu Lys Val 
 145                150                155                160
Lys Glu Gly Arg Leu Ser Phe Tyr Ser Gly His Ser Ser Phe Ser Met 
                 165                170                175
Tyr Cys Met Leu Phe Val Ala Leu Tyr Leu Gln Ala Arg Met Lys Gly 
             180                185                190
Asp Trp Ala Arg Leu Leu Arg Pro Met Leu Gln Phe Gly Leu Ile Ala 
         195                200                205
Phe Ser Ile Tyr Val Gly Leu Ser Arg Val Ser Asp Tyr Lys His His 
     210                215                220
Trp Ser Asp Val Thr Val Gly Leu Ile Gln Gly Ala Ala Met Ala Ile 
 225                230                235                240
Leu Val Ala Leu Tyr Val Ser Asp Phe Phe Lys Asp Thr His Ser Tyr 
                 245                250                255
Lys Glu Arg Lys Glu Glu Asp Pro His Thr Thr Leu His Glu Thr Ala 
             260                265                270
Ser Ser Arg Asn Tyr Ser Thr Asn His Glu Pro 
         275                280



<210> 7175
<211> 3352
<212> DNA
<213> Homo sapiens
<308> D29641
<400> 7175

ctgctccca  aaatggcgg  cgcattcgg  gatgagctg  tcagcgtgt  cgagggcga  60
tcgaccact  cggcgggaa  caaaaaaga  aaggaaaag  acaagggga  atggaaggg  120
cctccaggg  ctgcagaca  ggcagggaa  cgttttgat  gtaaattac  atcagaatc  180
actaataat  gaaaaaata  gagagatgt  gatttcgaa  gtacagatg  acccatttt  240
ggaaagaag  ccaggatag  agagtcaat  actgaagac  taagtttgg  agacctgat  300
cccagagtc  aggtacaat  agttgaaac  gttgaaggg  gtacacatg  ggttgcact  360
cctgcagaa  aggattatt  accacttaa  ccacgagtt  gaaaagctg  taaggaata  420
ccgttcatt  ttgatgctt  tcaaagaga  gccattcag  gtgttgaca  taatcagtc  480
gttctagta  ctgcacata  ctcagcggg  aaaacagta  gcgccgagt  tgccattgc  540
ttggcctta  gggaaaagc  gcgtgtaat  tttaccagc  caattaagg  tctgagtaa  600
caaaaatac  gtgaaatgt  tgaagaatt  caagatgtt  gtttgatga  tggtgatgt  660
actattaat  ctacggcat  ttgtcttgt  atgaccaca  agattttga  aagtatgct  720
tacagaggt  ccgaagtta  gagagaagt  gcttgggtt  tatttgatg  aattcatta  780
atgagagat  cagaacgtg  tgtagtatg  gaagaaact  ttattttgc  tcctgataa  840
gtccactat  tctttcttt  ggctactat  ccaaatgcc  gacagtttg  tgaatggat  900
tgccattta  ataaacagc  ttgtcatgt  atttacaca  attatcggc  cactccatt  960
caacactac  tttttccag  agggggaga  ggcctgcat  ttgtggttg  tgaaaatgg  1020
gacttcaga  aagataatt  taatactgc  atgcaagtg  ttcgagatg  aggtgattt  1080
gccaaagga  accagaaag  gcggaaagg  ggaacaaaa  gaccatcaa  tgttttcaa  1140
attgtgaag  tgattatgg  aagaaattt  caacctgtg  ttattttca  ttttagtaa  1200
aaagattgt  aagcctatg  acttcaaat  accaaatta  atttcaaca  agatgaaga  1260
aagaagatg  ttgaagaag  attcagtaa  gcaattgat  gcttatccg  tgaagataa  1320
aaactccct  aggtagaac  tgtacttcc  cttttgaag  ggggaattg  tattcacca  1380
ggtggttta  ttcctattt  gaaagaaac  atagaaatt  tcttttctg  aggattgat  1440
aaggcctta  ttgccacgg  gacctttgc  atgggaatt  acatgccag  tagaactgt  1500
ttatttaca  atgcccgca  atttgatgg  aaggatttc  gatggattt  ttctggtga  1560
tacattcag  tgtctggtc  tgctggaag  agaggaatg  atgatagag  aattgtaat  1620
cttatggta  atgaaaaga  gagcccaac  attggaaaa  aattactta  gggctccgc  1680
gatcctcta  atagtgctt  ccatttgac  tacaacatg  ttttgaact  actacgtgt  1740
gaagaaatt  atcctgagt  catgttgga  aaatccttc  accagtttc  gcattatag  1800
gcaattcca  gagtagtag  gaaggtaaa  aattcagaa  aacagtata  taaaatagt  1860
attcccaat  aagaaagtg  ggttatcta  tataagatt  gacagcagc  tgccaaatt  1920
ggtaaagaa  ttgaagaat  tattcacaa  ccaaaatac  gcttacctt  tctacaacc  1980
ggtcgtttg  taaaggtaa  gaatgaagg  gatgacttt  gctggggag  agtggtgaa  2040
ttctcaaaa  agtcaaatg  taagcctaa  tctggtgaa  tggatcctt  gtatgtagt  2100
gaagtactt  tgcgctgta  caaagagag  ttgaaaaat  cagctacag  agctgcaaa  2160
ccagctaaa  ctgatgaga  aggagagat  caggttgtc  cagttttgg  gcatctcct  2220
tctgctatc  gcagtgtta  gctttacat  cctaaagac  ttcggccgg  ggacaatag  2280
cagagtgtt  taaaatcaa  acaggaagt  cagaaacgt  ttcctgacg  catcccctt  2340
ttagaccct  ttgatgata  gggcattca  gatcaaggg  tgaaaaaag  cattcagaa  2400
gtagaagct  ttgagcatc  aatgtattc  catccactt  acaatgatc  aaatttgga  2460
actgtgtat  cgctttgtg  aaaaaaagc  cagattgca  tagatatta  atctgcaaa  2520
cgagaactg  agaaagcaa  aacagtcct  caaatggat  aactcaaat  tcgcaaacg  2580
gttttaaga  ggttgggat  tgctacttc  tctgatgta  tagagatga  aggacgagt  2640
gcttgtgag  taagcagtg  tgatgagct  cttctaact  agatgatgt  taatggcct  2700
ttcaatgac  tttctgcag  acaggcaac  gcattatta  gctgctttg  gtttcaaga  2760
aattctagt  agatgccca  attaacaga  caattagca  gaccacttc  tcaaatgca  2820
gaatgtgct  aaagaattg  aaaagtttc  gcagaagcc  aattggaaa  tgatgagga  2880
acttatcta  gctcattta  acctcactt  atggatgta  tatatacct  ggcaactgg  2940
gctacattt  cccatatct  caaaatgac  gatgtcttt  aaggcagca  aattcgttg  3000
atgaggcgc  tggaagaat  gcttcgaca  atgtgtcaa  cagcaaaag  cattggaaa  3060
actgagctg  aaaataaat  tgcagaagg  atcaccaaa  tcaagagag  tattgtgtt  3120
gctgccagc  tctacttgt  gagtcagct  aaggaatgt  agattttaa  ttattgacc  3180
cctgtttga  tacagttga  tacaaatgc  tgcaagtgt  gatttggtt  tcccataca  3240
tttaatatg  attatattt  aatcaaaca  cattcatag  aagcatatt  catacatgt  3300
tatacataa  cattacatt  ttttaataa  aatgtatac  ggtggggca  tg  3352



<210> 7176
<211> 1046
<212> PRT
<213> Homo sapiens
<308> P42285
<400> 7176

Leu Leu Pro Lys Met Ala Asp Ala Phe Gly Asp Glu Leu Phe Ser Val 
  1               5                  10                  15
Phe Glu Gly Asp Ser Thr Thr Ala Ala Gly Thr Lys Lys Asp Lys Glu 
             20                  25                  30
Lys Asp Lys Gly Lys Trp Lys Gly Pro Pro Gly Ser Ala Asp Lys Ala 
         35                  40                  45
Gly Lys Arg Phe Asp Gly Lys Leu Gln Ser Glu Ser Thr Asn Asn Gly 
     50                  55                  60
Lys Asn Lys Arg Asp Val Asp Phe Glu Gly Thr Asp Glu Pro Ile Phe 
 65                  70                  75                  80
Gly Lys Lys Pro Arg Ile Glu Glu Ser Ile Thr Glu Asp Leu Ser Leu 
                 85                  90                  95
Ala Asp Leu Met Pro Arg Val Lys Val Gln Ser Val Glu Thr Val Glu 
             100                105                110
Gly Cys Thr His Glu Val Ala Leu Pro Ala Glu Glu Asp Tyr Leu Pro 
         115                120                125
Leu Lys Pro Arg Val Gly Lys Ala Ala Lys Glu Tyr Pro Phe Ile Leu 
     130                135                140
Asp Ala Phe Gln Arg Glu Ala Ile Gln Cys Val Asp Asn Asn Gln Ser 
 145                150                155                160
Val Leu Val Ser Ala His Thr Ser Ala Gly Lys Thr Val Cys Ala Glu 
                 165                170                175
Tyr Ala Ile Ala Leu Ala Leu Arg Glu Lys Gln Arg Val Ile Phe Thr 
             180                185                190
Ser Pro Ile Lys Ala Leu Ser Asn Gln Lys Tyr Arg Glu Met Tyr Glu 
         195                200                205
Glu Phe Gln Asp Val Gly Leu Met Thr Gly Asp Val Thr Ile Asn Pro 
     210                215                220
Thr Ala Ser Cys Leu Val Met Thr Thr Glu Ile Leu Arg Ser Met Leu 
 225                230                235                240
Tyr Arg Gly Ser Glu Val Met Arg Glu Val Ala Trp Val Ile Phe Asp 
                 245                250                255
Glu Ile His Tyr Met Arg Asp Ser Glu Arg Gly Val Val Trp Glu Glu 
             260                265                270
Thr Ile Ile Leu Leu Pro Asp Asn Val His Tyr Val Phe Leu Ser Ala 
         275                280                285
Thr Ile Pro Asn Ala Arg Gln Phe Ala Glu Trp Ile Cys His Leu His 
     290                295                300
Lys Gln Pro Cys His Val Ile Tyr Thr Asp Tyr Arg Pro Thr Pro Leu 
 305                310                315                320
Gln His Tyr Ile Phe Pro Ala Gly Gly Asp Gly Leu His Leu Val Val 
                 325                330                335
Asp Glu Asn Gly Asp Phe Arg Glu Asp Asn Phe Asn Thr Ala Met Gln 
             340                345                350
Val Leu Arg Asp Ala Gly Asp Leu Ala Lys Gly Asp Gln Lys Gly Arg 
         355                360                365
Lys Gly Gly Thr Lys Gly Pro Ser Asn Val Phe Lys Ile Val Lys Met 
     370                375                380
Ile Met Glu Arg Asn Phe Gln Pro Val Ile Ile Phe Ser Phe Ser Lys 
 385                390                395                400
Lys Asp Cys Glu Ala Tyr Ala Leu Gln Met Thr Lys Leu Asp Phe Asn 
                 405                410                415
Thr Asp Glu Glu Lys Lys Met Val Glu Glu Val Phe Ser Asn Ala Ile 
             420                425                430
Asp Cys Leu Ser Asp Glu Asp Lys Lys Leu Pro Gln Val Glu His Val 
         435                440                445
Leu Pro Leu Leu Lys Arg Gly Ile Gly Ile His His Gly Gly Leu Leu 
     450                455                460
Pro Ile Leu Lys Glu Thr Ile Glu Ile Leu Phe Ser Glu Gly Leu Ile 
 465                470                475                480
Lys Ala Leu Phe Ala Thr Glu Thr Phe Ala Met Gly Ile Asn Met Pro 
                 485                490                495
Ala Arg Thr Val Leu Phe Thr Asn Ala Arg Lys Phe Asp Gly Lys Asp 
             500                505                510
Phe Arg Trp Ile Ser Ser Gly Glu Tyr Ile Gln Met Ser Gly Arg Ala 
         515                520                525
Gly Arg Arg Gly Met Asp Asp Arg Gly Ile Val Ile Leu Met Val Asp 
     530                535                540
Glu Lys Met Ser Pro Thr Ile Gly Lys Gln Leu Leu Lys Gly Ser Ala 
 545                550                555                560
Asp Pro Leu Asn Ser Ala Phe His Leu Thr Tyr Asn Met Val Leu Asn 
                 565                570                575
Leu Leu Arg Val Glu Glu Ile Asn Pro Glu Tyr Met Leu Glu Lys Ser 
             580                585                590
Phe Tyr Gln Phe Gln His Tyr Arg Ala Ile Pro Gly Val Val Glu Lys 
         595                600                605
Val Lys Asn Ser Glu Glu Gln Tyr Asn Lys Ile Val Ile Pro Asn Glu 
     610                615                620
Glu Ser Val Val Ile Tyr Tyr Lys Ile Arg Gln Gln Leu Ala Lys Leu 
 625                630                635                640
Gly Lys Glu Ile Glu Glu Tyr Ile His Lys Pro Lys Tyr Cys Leu Pro 
                 645                650                655
Phe Leu Gln Pro Gly Arg Leu Val Lys Val Lys Asn Glu Gly Asp Asp 
             660                665                670
Phe Gly Trp Gly Val Val Val Asn Phe Ser Lys Lys Ser Asn Val Lys 
         675                680                685
Pro Asn Ser Gly Glu Leu Asp Pro Leu Tyr Val Val Glu Val Leu Leu 
     690                695                700
Arg Cys Ser Lys Glu Ser Leu Lys Asn Ser Ala Thr Glu Ala Ala Lys 
 705                710                715                720
Pro Ala Lys Pro Asp Glu Lys Gly Glu Met Gln Val Val Pro Val Leu 
                 725                730                735
Val His Leu Leu Ser Ala Ile Ser Ser Val Arg Leu Tyr Ile Pro Lys 
             740                745                750
Asp Leu Arg Pro Val Asp Asn Arg Gln Ser Val Leu Lys Ser Ile Gln 
         755                760                765
Glu Val Gln Lys Arg Phe Pro Asp Gly Ile Pro Leu Leu Asp Pro Ile 
     770                775                780
Asp Asp Met Gly Ile Gln Asp Gln Gly Leu Lys Lys Val Ile Gln Lys 
 785                790                795                800
Val Glu Ala Phe Glu His Arg Met Tyr Ser His Pro Leu His Asn Asp 
                 805                810                815
Pro Asn Leu Glu Thr Val Tyr Thr Leu Cys Glu Lys Lys Ala Gln Ile 
             820                825                830
Ala Ile Asp Ile Lys Ser Ala Lys Arg Glu Leu Lys Lys Ala Arg Thr 
         835                840                845
Val Leu Gln Met Asp Glu Leu Lys Cys Arg Lys Arg Val Leu Arg Arg 
     850                855                860
Leu Gly Phe Ala Thr Ser Ser Asp Val Ile Glu Met Lys Gly Arg Val 
 865                870                875                880
Ala Cys Glu Ile Ser Ser Ala Asp Glu Leu Leu Leu Thr Glu Met Met 
                 885                890                895
Phe Asn Gly Leu Phe Asn Asp Leu Ser Ala Glu Gln Ala Thr Ala Leu 
             900                905                910
Leu Ser Cys Phe Val Phe Gln Glu Asn Ser Ser Glu Met Pro Lys Leu 
         915                920                925
Thr Glu Gln Leu Ala Gly Pro Leu Arg Gln Met Gln Glu Cys Ala Lys 
     930                935                940
Arg Ile Ala Lys Val Ser Ala Glu Ala Lys Leu Glu Ile Asp Glu Glu 
 945                950                955                960
Thr Tyr Leu Ser Ser Phe Lys Pro His Leu Met Asp Val Val Tyr Thr 
                 965                970                975
Trp Ala Thr Gly Ala Thr Phe Ala His Ile Cys Lys Met Thr Asp Val 
             980                985                990
Phe Glu Gly Ser Ile Ile Arg Cys Met Arg Arg Leu Glu Glu Leu Leu 
         995                1000                1005
Arg Gln Met Cys Gln Ala Ala Lys Ala Ile Gly Asn Thr Glu Leu Glu 
     1010                1015                1020
Asn Lys Phe Ala Glu Gly Ile Thr Lys Ile Lys Arg Asp Ile Val Phe 
 1025                1030                1035                1040
Ala Ala Ser Leu Tyr Leu 
                 1045



<210> 7177
<211> 292
<212> DNA
<213> Rattus norvegicus
<308> AI230572
<400> 7177

gcccgttga  cagatccac  agaactgtc  gcattatct  tgcagcatg  ggtttttat  60
atttttacc  aaagatgtc  ctttttggt  atgacaaac  tgtttttta  gaaaaaaaa  120
aaaaggcct  gtttttctc  atacacctt  aacggtttt  aaattgttt  atatctggt  180
aagttgaga  ttttaagaa  ttcattttt  atttgtaat  aagtttaca  cttgatttt  240
tcaaaaaag  caacaaact  caagcacct  ttaataaag  tcttaaata  ta  292



<210> 7178
<211> 322
<212> PRT
<213> Rattus norvegicus
<308> P27817
<400> 7178

Met Ser Ser Glu Ala Glu Thr Gln Gln Pro Pro Ala Ala Pro Ala Ala 
  1               5                  10                  15
Ala Leu Ser Ala Ala Asp Thr Lys Pro Gly Ser Thr Gly Ser Gly Ala 
             20                  25                  30
Gly Ser Gly Gly Pro Gly Gly Leu Thr Ser Ala Ala Pro Ala Gly Gly 
         35                  40                  45
Asp Lys Lys Val Ile Ala Thr Lys Val Leu Gly Thr Val Lys Trp Phe 
     50                  55                  60
Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr Lys Glu 
 65                  70                  75                  80
Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro Arg Lys 
                 85                  90                  95
Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp Val Val 
             100                105                110
Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro Gly Gly 
         115                120                125
Val Pro Val Gln Gly Ser Lys Tyr Ala Ala Asp Arg Asn His Tyr Arg 
     130                135                140
Arg Tyr Pro Arg Arg Arg Gly Pro Pro Arg Asn Tyr Gln Gln Asn Tyr 
 145                150                155                160
Gln Asn Ser Glu Ser Gly Glu Lys Asn Glu Gly Ser Glu Ser Ala Pro 
                 165                170                175
Glu Gly Gln Ala Gln Gln Arg Arg Pro Tyr Arg Arg Arg Arg Phe Pro 
             180                185                190
Pro Tyr Tyr Met Arg Arg Pro Tyr Ala Arg Arg Pro Gln Tyr Ser Asn 
         195                200                205
Pro Pro Val Gln Gly Glu Val Met Glu Gly Ala Asp Asn Gln Gly Ala 
     210                215                220
Gly Glu Gln Gly Arg Pro Val Arg Gln Asn Met Tyr Arg Gly Tyr Arg 
 225                230                235                240
Pro Arg Phe Arg Arg Gly Pro Pro Arg Gln Arg Gln Pro Arg Glu Asp 
                 245                250                255
Gly Asn Glu Glu Asp Lys Glu Asn Gln Gly Asp Glu Thr Gln Gly Gln 
             260                265                270
Gln Pro Pro Gln Arg Arg Tyr Arg Arg Asn Phe Asn Tyr Arg Arg Arg 
         275                280                285
Arg Pro Glu Asn Pro Lys Pro Gln Asp Gly Lys Glu Thr Lys Ala Ala 
     290                295                300
Asp Pro Pro Ala Glu Asn Ser Ser Ala Pro Glu Ala Glu Gln Gly Gly 
 305                310                315                320
Ala Glu 
                 325



<210> 7179
<211> 331
<212> DNA
<213> Homo sapiens
<308> AI915610
<400> 7179

ttttttgaa  ttttactca  tccaaataa  acttaattt  ttgaagaca  cacgccgca  60
cccttacga  tgcccagga  gctgcttgc  agaccctgt  ccgggctga  acctgcgag  120
aacctccct  ccccaccct  ctccctcgt  cttttcccc  ctctcacta  tctggtaat  180
ttgctggta  ttgcgtgga  gacccctac  acgtggata  cgtctataa  ggttaccgg  240
ctgctgcat  tttactgcc  tgaactgga  caccaccag  acctgtaac  tttgctgcc  300
ccgaccctt  tctccttca  aactcaaac  c  331



<210> 7180
<211> 292
<212> DNA
<213> Rattus norvegicus
<308> AI230572
<400> 7180

gcccgttga  cagatccac  agaactgtc  gcattatct  tgcagcatg  ggtttttat  60
atttttacc  aaagatgtc  ctttttggt  atgacaaac  tgtttttta  gaaaaaaaa  120
aaaaggcct  gtttttctc  atacacctt  aacggtttt  aaattgttt  atatctggt  180
aagttgaga  ttttaagaa  ttcattttt  atttgtaat  aagtttaca  cttgatttt  240
tcaaaaaag  caacaaact  caagcacct  ttaataaag  tcttaaata  ta  292



<210> 7181
<211> 322
<212> PRT
<213> Rattus norvegicus
<308> P27817
<400> 7181

Met Ser Ser Glu Ala Glu Thr Gln Gln Pro Pro Ala Ala Pro Ala Ala 
  1               5                  10                  15
Ala Leu Ser Ala Ala Asp Thr Lys Pro Gly Ser Thr Gly Ser Gly Ala 
             20                  25                  30
Gly Ser Gly Gly Pro Gly Gly Leu Thr Ser Ala Ala Pro Ala Gly Gly 
         35                  40                  45
Asp Lys Lys Val Ile Ala Thr Lys Val Leu Gly Thr Val Lys Trp Phe 
     50                  55                  60
Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr Lys Glu 
 65                  70                  75                  80
Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro Arg Lys 
                 85                  90                  95
Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp Val Val 
             100                105                110
Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro Gly Gly 
         115                120                125
Val Pro Val Gln Gly Ser Lys Tyr Ala Ala Asp Arg Asn His Tyr Arg 
     130                135                140
Arg Tyr Pro Arg Arg Arg Gly Pro Pro Arg Asn Tyr Gln Gln Asn Tyr 
 145                150                155                160
Gln Asn Ser Glu Ser Gly Glu Lys Asn Glu Gly Ser Glu Ser Ala Pro 
                 165                170                175
Glu Gly Gln Ala Gln Gln Arg Arg Pro Tyr Arg Arg Arg Arg Phe Pro 
             180                185                190
Pro Tyr Tyr Met Arg Arg Pro Tyr Ala Arg Arg Pro Gln Tyr Ser Asn 
         195                200                205
Pro Pro Val Gln Gly Glu Val Met Glu Gly Ala Asp Asn Gln Gly Ala 
     210                215                220
Gly Glu Gln Gly Arg Pro Val Arg Gln Asn Met Tyr Arg Gly Tyr Arg 
 225                230                235                240
Pro Arg Phe Arg Arg Gly Pro Pro Arg Gln Arg Gln Pro Arg Glu Asp 
                 245                250                255
Gly Asn Glu Glu Asp Lys Glu Asn Gln Gly Asp Glu Thr Gln Gly Gln 
             260                265                270
Gln Pro Pro Gln Arg Arg Tyr Arg Arg Asn Phe Asn Tyr Arg Arg Arg 
         275                280                285
Arg Pro Glu Asn Pro Lys Pro Gln Asp Gly Lys Glu Thr Lys Ala Ala 
     290                295                300
Asp Pro Pro Ala Glu Asn Ser Ser Ala Pro Glu Ala Glu Gln Gly Gly 
 305                310                315                320
Ala Glu 
                 325



<210> 7182
<211> 331
<212> DNA
<213> Homo sapiens
<308> AI915610
<400> 7182

ttttttgaa  ttttactca  tccaaataa  acttaattt  ttgaagaca  cacgccgca  60
cccttacga  tgcccagga  gctgcttgc  agaccctgt  ccgggctga  acctgcgag  120
aacctccct  ccccaccct  ctccctcgt  cttttcccc  ctctcacta  tctggtaat  180
ttgctggta  ttgcgtgga  gacccctac  acgtggata  cgtctataa  ggttaccgg  240
ctgctgcat  tttactgcc  tgaactgga  caccaccag  acctgtaac  tttgctgcc  300
ccgaccctt  tctccttca  aactcaaac  c  331



<210> 7183
<211> 643
<212> DNA
<213> Rattus norvegicus
<308> AI230748
<400> 7183

ttttttttg  atttaaatg  actttattt  tagacaacc  acatgacat  ttttttttt  60
ctttttaaa  aaaaaaaaa  aaacaatgc  tccactcca  ataaatcac  gtcaaaata  120
aagctcaag  tgatatcag  cccatttgt  ctaagtcct  gtgttgtat  gatggtaag  180
agcagccaa  tatggtgac  ggcgataga  ccaatttgt  aacattttt  catctctaa  240
ccatcctta  agaaaatca  gaatggagt  acaccatct  cacggtagt  caggagagc  300
accatgcca  ctggattca  gttttcacc  ataaaaaac  ggtagttat  gaaattagc  360
aggatgtgc  taatttgct  tgcagctcc  gtcataaaa  gctttaccc  ttctggttt  420
tgttcttca  gtttgccct  gagtgattt  atgtagtct  tgatatact  tttgtaggc  480
tcttttgtg  agctggttt  ttgtaagtg  tggttcatg  caatgtcaa  accggtgac  540
actgtgctt  cggtacctt  gccctccgg  ccttcagcg  aagcatttc  accaatgag  600
gaatcatcg  tggcaccct  tgttctact  accatcttg  cct  643



<210> 7184
<211> 172
<212> PRT
<213> Rattus norvegicus
<308> P14701
<400> 7184

Met Ile Ile Tyr Arg Asp Leu Ile Ser His Asp Glu Leu Phe Ser Asp 
  1               5                  10                  15
Ile Tyr Lys Ile Arg Glu Ile Ala Asp Gly Leu Cys Leu Glu Val Glu 
             20                  25                  30
Gly Lys Met Val Ser Arg Thr Glu Gly Ala Ile Asp Asp Ser Leu Ile 
         35                  40                  45
Gly Gly Asn Ala Ser Ala Glu Gly Pro Glu Gly Glu Gly Thr Glu Ser 
     50                  55                  60
Thr Val Val Thr Gly Val Asp Ile Val Met Asn His His Leu Gln Glu 
 65                  70                  75                  80
Thr Ser Phe Thr Lys Glu Ala Tyr Lys Lys Tyr Ile Lys Asp Tyr Met 
                 85                  90                  95
Lys Ser Leu Lys Gly Lys Leu Glu Glu Gln Lys Pro Glu Arg Val Lys 
             100                105                110
Pro Phe Met Thr Gly Ala Ala Glu Gln Ile Lys His Ile Leu Ala Asn 
         115                120                125
Phe Asn Asn Tyr Gln Phe Phe Ile Gly Glu Asn Met Asn Pro Asp Gly 
     130                135                140
Met Val Ala Leu Leu Asp Tyr Arg Glu Asp Gly Val Thr Pro Phe Met 
 145                150                155                160
Ile Phe Phe Lys Asp Gly Leu Glu Met Glu Lys Cys 
                 165                170



<210> 7185
<211> 830
<212> DNA
<213> Homo sapiens
<308> NM_003295
<400> 7185

cccccccga  cgccgctcc  gctgcaccg  gctcgctcc  agtttcagg  tcgtgctaa  60
ctagcgccg  cgtcgtctc  cttcagtcg  catcatgat  atctaccgg  acctcatca  120
ccacgatga  atgttctcc  acatctaca  gatccggga  atcgcggac  ggttgtgcc  180
ggaggtgga  gggaagatg  tcagtagga  agaaggtaa  attgatgac  cgctcattg  240
tggaaatgc  tccgctgaa  gccccgagg  cgaaggtac  gaaagcaca  taatcactg  300
tgtcgatat  gtcatgaac  atcacctgc  ggaaacaag  ttcacaaaa  aagcctaca  360
gaagtacat  aaagattac  tgaaatcaa  caaagggaa  cttgaagaa  agagaccag  420
aagagtaaa  ccttttatg  caggggctg  agaacaaat  aagcacatc  ttgctaatt  480
caaaaacta  cagttcttt  ttggtgaaa  catgaatcc  gatggcatg  ttgctctat  540
ggactaccg  gaggatggt  tgaccccat  tatgatttt  tttaaggat  gtttagaaa  600
ggaaaaatg  taacaaatg  ggcaattat  ttggatcta  cacctgtca  cataactgg  660
ttctgcttg  catccacac  acaccagga  ttaagacaa  tgggactga  gtcatcttg  720
gctcttcat  tattttgac  gtgatttat  tggagtgga  gcattgttt  taagaaaaa  780
atgtcatgt  ggttgtcta  aaataaaat  catttaaac  catttgagag  830



<210> 7186
<211> 172
<212> PRT
<213> Homo sapiens
<308> P13693
<400> 7186

Met Ile Ile Tyr Arg Asp Leu Ile Ser His Asp Glu Met Phe Ser Asp 
  1               5                  10                  15
Ile Tyr Lys Ile Arg Glu Ile Ala Asp Gly Leu Cys Leu Glu Val Glu 
             20                  25                  30
Gly Lys Met Val Ser Arg Thr Glu Gly Asn Ile Asp Asp Ser Leu Ile 
         35                  40                  45
Gly Gly Asn Ala Ser Ala Glu Gly Pro Glu Gly Glu Gly Thr Glu Ser 
     50                  55                  60
Thr Val Ile Thr Gly Val Asp Ile Val Met Asn His His Leu Gln Glu 
 65                  70                  75                  80
Thr Ser Phe Thr Lys Glu Ala Tyr Lys Lys Tyr Ile Lys Asp Tyr Met 
                 85                  90                  95
Lys Ser Ile Lys Gly Lys Leu Glu Glu Gln Arg Pro Glu Arg Val Lys 
             100                105                110
Pro Phe Met Thr Gly Ala Ala Glu Gln Ile Lys His Ile Leu Ala Asn 
         115                120                125
Phe Lys Asn Tyr Gln Phe Phe Ile Gly Glu Asn Met Asn Pro Asp Gly 
     130                135                140
Met Val Ala Leu Leu Asp Tyr Arg Glu Asp Gly Val Thr Pro Tyr Met 
 145                150                155                160
Ile Phe Phe Lys Asp Gly Leu Glu Met Glu Lys Cys 
                 165                170



<210> 7187
<211> 527
<212> DNA
<213> Rattus norvegicus
<308> AI231007
<400> 7187

aatttctgt  tttttttct  tattgtatc  tcatgggac  ttaggggtt  tatatggta  60
gacacccaa  gttttggta  aacattatc  aatatatat  cagacgatt  ttccctaga  120
gaaaaaaca  tctttatgc  tgattttaa  aagttgaaa  gaggtggat  tttccttta  180
ggtgctgaa  ggaaggatg  agaatgagg  gaaaataaa  ctgtgagga  caagactgg  240
atcttgtct  tacttattt  caggacaac  ggggagaac  tgctgattt  cagagctga  300
cccagcctg  gacttcggg  aatcactga  cacacagcc  atgtctgcc  tattggttc  360
actactcag  ccctccaag  ctgtttcat  actgagagg  cattagcaa  tgcatgggt  420
ggcagaggt  ggacaaggc  gaatggcca  ctgaggaat  tctgcactt  ctgattcaa  480
aaggttagg  catcacagc  agggtcttc  gacataaga  aggagaa  527



<210> 7188
<211> 635
<212> PRT
<213> Rattus norvegicus
<308> BAA22932
<400> 7188

Met Val Leu Tyr Thr Thr Pro Phe Pro Asn Ser Cys Leu Ser Ala Leu 
  1               5                  10                  15
His Ala Val Ser Trp Ala Leu Ile Phe Pro Cys Tyr Trp Leu Val Asp 
             20                  25                  30
Arg Leu Val Ala Ser Phe Ile Pro Thr Thr Tyr Glu Lys Arg Gln Arg 
         35                  40                  45
Ala Asp Asp Pro Cys Tyr Leu Gln Leu Phe Cys Thr Val Leu Phe Thr 
     50                  55                  60
Pro Val Tyr Leu Ala Leu Leu Val Ala Ala Leu Pro Phe Ala Phe Leu 
 65                  70                  75                  80
Gly Phe Ile Phe Trp Ser Pro Leu Gln Ser Ala Arg Arg Pro Tyr Ser 
                 85                  90                  95
Tyr Ser Arg Leu Glu Asp Lys Ser Pro Ala Gly Gly Ala Ala Leu Leu 
             100                105                110
Ser Glu Trp Lys Gly Thr Gly Ala Gly Lys Ser Phe Cys Phe Ala Thr 
         115                120                125
Ala Asn Val Cys Leu Leu Pro Asp Ser Leu Ala Arg Leu Asn Asn Val 
     130                135                140
Phe Asn Thr Gln Ala Arg Ala Lys Glu Ile Gly Gln Arg Ile Arg Asn 
 145                150                155                160
Gly Ala Ala Arg Pro Gln Ile Lys Ile Tyr Ile Asp Ser Pro Thr Asn 
                 165                170                175
Thr Ser Ile Ser Ala Ala Ser Phe Ser Ser Leu Val Ser Pro Gln Gly 
             180                185                190
Ser Asp Gly Ala Arg Ala Val Pro Gly Ser Ile Lys Arg Thr Ala Ser 
         195                200                205
Val Glu Tyr Lys Gly Asp Gly Gly Arg His Pro Ser Asp Glu Ala Ala 
     210                215                220
Asn Gly Pro Ala Ser Gly Glu Gln Ala Asp Gly Ser Leu Glu Asp Ser 
 225                230                235                240
Cys Ile Val Arg Ile Gly Gly Glu Glu Gly Gly Arg Ala Gln Glu Ala 
                 245                250                255
Asp Asp Pro Ala Pro Gly Ser Gln Ala Arg Asn Gly Ala Gly Gly Thr 
             260                265                270
Pro Lys Gly Gln Thr Pro Asn His Asn Gln Arg Asp Gly Asp Ser Gly 
         275                280                285
Ser Leu Gly Ser Pro Ser Ala Ser Arg Glu Ser Leu Val Lys Ala Arg 
     290                295                300
Ala Gly Gln Asp Ser Gly Gly Ser Gly Glu Pro Gly Ser Asn Ser Lys 
 305                310                315                320
Leu Leu Tyr Lys Thr Ser Val Val Lys Lys Ala Ala Ala Arg Arg Arg 
                 325                330                335
Arg His Pro Asp Glu Ala Phe Asp His Glu Val Ser Ala Phe Phe Pro 
             340                345                350
Ala Asn Leu Asp Phe Leu Cys Leu Gln Glu Val Phe Asp Lys Arg Ala 
         355                360                365
Ala Ala Lys Leu Lys Glu Gln Leu His Gly Tyr Phe Glu Tyr Ile Leu 
     370                375                380
Tyr Asp Val Gly Val Tyr Gly Cys His Gly Cys Cys Asn Phe Lys Cys 
 385                390                395                400
Leu Asn Ser Gly Leu Phe Phe Ala Ser Arg Tyr Pro Val Met Asp Val 
                 405                410                415
Ala Tyr His Cys Tyr Pro Asn Gly Cys Ser Phe Asp Ala Leu Ala Ser 
             420                425                430
Lys Gly Ala Leu Phe Leu Lys Val Gln Val Gly Ser Thr Pro Gln Asp 
         435                440                445
Gln Arg Ile Val Gly Tyr Ile Ala Cys Thr His Leu His Ala Pro Pro 
     450                455                460
Glu Asp Ser Ala Ile Arg Cys Glu Gln Leu Asp Leu Leu Gln Asp Trp 
 465                470                475                480
Leu Ala Asp Phe Arg Lys Ser Thr Ser Ser Thr Ser Thr Ala Asn Pro 
                 485                490                495
Glu Glu Leu Val Val Phe Asp Val Ile Cys Gly Asp Leu Asn Phe Asp 
             500                505                510
Asn Cys Ser Ser Asp Asp Lys Leu Glu Gln Gln His Ser Leu Phe Thr 
         515                520                525
Arg Tyr Lys Asp Pro Cys Arg Leu Gly Pro Gly Glu Glu Lys Pro Trp 
     530                535                540
Ala Ile Gly Thr Leu Leu Asp Ile Asn Gly Leu Tyr Asp Glu Asp Val 
 545                550                555                560
Cys Thr Pro Asp Asn Leu Gln Lys Val Leu Glu Ser Glu Glu Gly Arg 
                 565                570                575
Arg Glu Tyr Leu Ala Phe Pro Thr Ser Lys Ser Pro Gly Ala Gly Gln 
             580                585                590
Lys Gly Arg Lys Asp Leu Leu Lys Gly Asn Gly Arg Arg Ile Asp Tyr 
         595                600                605
Met Leu His Ala Glu Glu Gly Cys Ala Leu Thr Gly Arg Leu Arg Trp 
     610                615                620
Lys Asn Ser Val Leu Ser Pro Ser Cys Pro Ala 
 625                630                635



<210> 7189
<211> 1450
<212> DNA
<213> Homo sapiens
<308> AK026246
<400> 7189

cttgaggga  tgtttttga  aatccccgc  gacctccgc  cctcgtggc  ccctggccc  60
acacccagc  tggcccagg  ccggctttg  ctggtgagg  tggagggag  accaggacc  120
gctgtctgc  gtcagcccc  cctggtgct  gtgccctga  gctgtgcct  gtcacccat  180
gagctgcaa  agggaccaa  agggggcca  gcagccagc  agatgcctg  ccctgtgct  240
gggcagaca  cgctgcaga  cccagggag  ctggcgcta  gacgtgcgt  cttgtgaca  300
tggcctgtc  gaactcacc  ggcctggga  gcaccgtct  cccgggccc  agccctgcc  360
ctccagagt  cagagccag  aaggggctg  tgagggcga  catcctgct  ggctctctg  420
ccggcccac  cctccaagg  gctggcctg  gagccttga  tgggattca  gatgtggag  480
cccccaact  ccagaagca  ctggtactc  gctcacaca  gcgactggg  cggccggcc  540
tggacccct  gaccccgag  cgcctgccg  ctgcctgca  agggagagc  gttgaggcc  600
gggcagggc  cccacacca  accccaaca  agcttcccc  cccaggcac  ccctcccgg  660
gcagcaggc  tgggagtca  ggctgcatg  tcctcccct  ccacctcac  ggcggcctt  720
ggcaagtca  tttctgtca  cacaaggtc  cctctgcct  gtcaggtcc  ggcgtccag  780
gtaaggatg  gcggccccc  ggcccccgc  cacctccct  agcaccaag  ccgggaccc  840
cccacccac  tgtctcatt  tggctgcct  tggactccc  ggccttgtg  gcaggccag  900
cccttccac  gatttttta  agtgaacca  tgctggatc  cagattctg  ggcatctaa  960
gcctagcag  ggtgggcac  cgggtcacc  gaggcccat  ccaagactc  gttcctgcc  1020
taggcccag  ctcaaagga  gccacaagg  gcgggggcc  ctgaggaag  aaatgttca  1080
tttcatttg  ccaaaacca  cttaagttt  aagtatatt  atcttgatg  tttttaact  1140
ttgcttttt  acttgctga  atttagaaa  actgttata  aaacttttt  aatttctgt  1200
tttttttct  tattgtatc  tcatgggac  ttaggggtt  tctatggta  gcacaccta  1260
ggttttggt  aaaacatta  caaatatat  tccagacgg  tcttcccta  aagaaaaac  1320
agtctttac  cctgataaa  tattttgcg  agagaggtg  tctttttcc  tactggtgc  1380
gaaaggaag  atggataac  aggagaaaa  aaaactgtg  ggctcaaaa  aaaaaaaaa  1440
aaaaaaaaaa  1450



<210> 7190
<211> 655
<212> PRT
<213> Homo sapiens
<308> NP_061137
<400> 7190

Met Val Leu Tyr Thr Thr Pro Phe Pro Asn Ser Cys Leu Ser Ala Leu 
  1               5                  10                  15
His Cys Val Ser Trp Ala Leu Ile Phe Pro Cys Tyr Trp Leu Val Asp 
             20                  25                  30
Arg Leu Ala Ala Ser Phe Ile Pro Thr Thr Tyr Glu Lys Arg Gln Arg 
         35                  40                  45
Ala Asp Asp Pro Cys Cys Leu Gln Leu Leu Cys Thr Ala Leu Phe Thr 
     50                  55                  60
Pro Ile Tyr Leu Ala Leu Leu Val Ala Ser Leu Pro Phe Ala Phe Leu 
 65                  70                  75                  80
Gly Phe Leu Phe Trp Ser Pro Leu Gln Ser Ala Arg Arg Pro Tyr Ile 
                 85                  90                  95
Tyr Ser Arg Leu Glu Asp Lys Gly Leu Ala Gly Gly Ala Ala Leu Leu 
             100                105                110
Ser Glu Trp Lys Gly Thr Gly Pro Gly Lys Ser Phe Cys Phe Ala Thr 
         115                120                125
Ala Asn Val Cys Leu Leu Pro Asp Ser Leu Ala Arg Val Asn Asn Leu 
     130                135                140
Phe Asn Thr Gln Ala Arg Ala Lys Glu Ile Gly Gln Arg Ile Arg Asn 
 145                150                155                160
Gly Ala Ala Arg Pro Gln Ile Lys Ile Tyr Ile Asp Ser Pro Thr Asn 
                 165                170                175
Thr Ser Ile Ser Ala Ala Ser Phe Ser Ser Leu Val Ser Pro Gln Gly 
             180                185                190
Gly Asp Gly Val Ala Arg Ala Val Pro Gly Ser Ile Lys Arg Thr Ala 
         195                200                205
Ser Val Glu Tyr Lys Gly Asp Gly Gly Arg His Pro Gly Asp Glu Ala 
     210                215                220
Ala Asn Gly Pro Ala Ser Gly Asp Pro Val Asp Ser Ser Ser Pro Glu 
 225                230                235                240
Asp Ala Cys Ile Val Arg Ile Gly Gly Glu Glu Gly Gly Arg Pro Pro 
                 245                250                255
Glu Ala Asp Asp Pro Val Pro Gly Gly Gln Ala Arg Asn Gly Ala Gly 
             260                265                270
Gly Gly Pro Arg Gly Gln Thr Pro Asn His Asn Gln Gln Asp Gly Asp 
         275                280                285
Ser Gly Ser Leu Gly Ser Pro Ser Ala Ser Arg Glu Ser Leu Val Lys 
     290                295                300
Gly Arg Ala Gly Pro Asp Thr Ser Ala Ser Gly Glu Pro Gly Ala Asn 
 305                310                315                320
Ser Lys Leu Leu Tyr Lys Ala Ser Val Val Lys Lys Ala Ala Ala Arg 
                 325                330                335
Arg Arg Arg His Pro Asp Glu Ala Phe Asp His Glu Val Ser Ala Phe 
             340                345                350
Phe Pro Ala Asn Leu Asp Phe Leu Cys Leu Gln Glu Val Phe Asp Lys 
         355                360                365
Arg Ala Ala Thr Lys Leu Lys Glu Gln Leu His Gly Tyr Phe Glu Tyr 
     370                375                380
Ile Leu Tyr Asp Val Gly Val Tyr Gly Cys Gln Gly Cys Cys Ser Phe 
 385                390                395                400
Lys Cys Leu Asn Ser Gly Leu Leu Phe Ala Ser Arg Tyr Pro Ile Met 
                 405                410                415
Asp Val Ala Tyr His Cys Tyr Pro Asn Lys Cys Asn Asp Asp Ala Leu 
             420                425                430
Ala Ser Lys Gly Ala Leu Phe Leu Lys Val Gln Val Gly Ser Thr Pro 
         435                440                445
Gln Asp Gln Arg Ile Val Gly Tyr Ile Ala Cys Thr His Leu His Ala 
     450                455                460
Pro Gln Glu Asp Ser Ala Ile Arg Cys Gly Gln Leu Asp Leu Leu Gln 
 465                470                475                480
Asp Trp Leu Ala Asp Phe Arg Lys Ser Thr Ser Ser Ser Ser Ala Ala 
                 485                490                495
Asn Pro Glu Glu Leu Val Ala Phe Asp Val Val Cys Gly Asp Phe Asn 
             500                505                510
Phe Asp Asn Cys Ser Ser Asp Asp Lys Leu Glu Gln Gln His Ser Leu 
         515                520                525
Phe Thr His Tyr Arg Asp Pro Cys Arg Leu Gly Pro Gly Glu Glu Lys 
     530                535                540
Pro Trp Ala Ile Gly Thr Leu Leu Asp Thr Asn Gly Leu Tyr Asp Glu 
 545                550                555                560
Asp Val Cys Thr Pro Asp Asn Leu Gln Lys Val Leu Glu Ser Glu Glu 
                 565                570                575
Gly Arg Arg Glu Tyr Leu Ala Phe Pro Thr Ser Lys Ser Ser Gly Gln 
             580                585                590
Lys Gly Arg Lys Glu Leu Leu Lys Gly Asn Gly Arg Arg Ile Asp Tyr 
         595                600                605
Met Leu His Ala Glu Glu Gly Leu Cys Pro Asp Trp Lys Ala Glu Val 
     610                615                620
Glu Glu Phe Ser Phe Ile Thr Gln Leu Ser Gly Leu Thr Asp His Leu 
 625                630                635                640
Pro Val Ala Met Arg Leu Met Val Ser Ser Gly Glu Glu Glu Ala 
                 645                650                655



<210> 7191
<211> 582
<212> DNA
<213> Rattus norvegicus
<308> AI231213
<400> 7191

ggattgtta  aaatcctcc  ttaatagtt  atttcagag  tgagcatat  gaaaccctc  60
cccaccctg  aaggcacag  ctcacccac  cttagccca  gggacaggg  acagctgcc  120
agaaatacc  gtccagatc  tccttctct  gtccagaca  ctcagggtc  tatgccaga  180
ctgagggac  catgcccct  agctgtcag  tccctcacc  aggaaaagc  cactggggg  240
tacctgggc  agtccccca  gcagcctct  cgttcagtt  cctgctgaa  tgagcttgg  300
gggagtatt  caagtgtgt  caagaactg  ctaccctgt  tcccacaga  acattgaaa  360
cccataaag  aagtgtcac  gtggggaaa  cactaacct  tcctgtggc  tttccctgg  420
cagccatgg  tgctagccc  ccctccctg  tttttaata  tatattgtt  taatatgac  480
tcagggtgg  gacccagct  tcctgtgta  agtaatact  ggagccatt  caagctgtt  540
aaaatattc  aggcagtag  aggaagagc  acaggacag  aa  582



<210> 7192
<211> 266
<212> PRT
<213> Rattus norvegicus
<308> O70352
<400> 7192

Met Gly Ala Gly Cys Val Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
  1               5                  10                  15
Asn Leu Leu Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
             20                  25                  30
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
         35                  40                  45
Ser Ser Ser Leu Gln Val Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
     50                  55                  60
Ile Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
 65                  70                  75                  80
Val Arg Cys Leu Leu Gly Leu Tyr Phe Val Phe Leu Leu Leu Ile Leu 
                 85                  90                  95
Ile Ala Gln Val Thr Val Glu Val Leu Phe Tyr Phe Asn Ala Asn Lys 
             100                105                110
Leu Lys Gln Glu Met Gly Asn Thr Val Met Asp Ile Ile Gln Asn Tyr 
         115                120                125
Ser Val Asn Ala Ser Ser Ser Arg Glu Glu Ala Trp Asp Tyr Val Gln 
     130                135                140
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Pro Ser Asn Trp Thr Arg 
 145                150                155                160
Asn Pro Val Leu Lys Asn Ser Thr Lys Thr Thr Tyr Pro Cys Ser Cys 
                 165                170                175
Glu Lys Thr Lys Glu Glu Asp Asn Gln Leu Ile Val Lys Lys Gly Phe 
             180                185                190
Cys Glu Ser Asp Asn Ser Thr Ala Ser Glu Asn Ser Pro Glu Asp Trp 
         195                200                205
Pro Val His Pro Glu Gly Cys Met Glu Lys Ala Gln Ala Trp Leu Gln 
     210                215                220
Glu Asn Phe Gly Ile Leu Leu Gly Val Cys Ala Gly Val Ala Val Ile 
 225                230                235                240
Glu Leu Leu Gly Leu Phe Leu Ser Ile Cys Leu Cys Arg Tyr Ile His 
                 245                250                255
Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
             260                265



<210> 7193
<211> 1623
<212> DNA
<213> Homo sapiens
<308> NM_002231
<400> 7193

gctgtgcag  ccgacgccg  ctgaggcac  agcgggtga  gctgggcct  cagcgcgga  60
cagaaagca  aacccgcag  gtcctccct  ctgctgtgt  gacgacacg  gggcacagg  120
agaagtggg  cctgtgacc  gctgcactg  tttcgtgga  ggaagctcc  ggactggcg  180
gatgggctc  gcctgtatc  aagtcacca  atactttct  ttcctcttc  acttgatct  240
ctttatcct  ggcgcagtg  tcctgggct  cggggtgtg  atcctggcc  acaagagca  300
tttcatctc  gtcctgcaa  cctcctcca  ctcgcttag  atgggggcc  atgtcttca  360
cggcgtggg  gcagtcact  tgctcatgg  cttcctggg  tgcatcggc  ccgtcaacg  420
ggtccgctg  ctgctgggg  tgtactttg  tttcctgct  ctgatcctc  ttgcccagg  480
gacggccgg  gccctcttc  acttcaaca  gggcaagct  aagcaggag  tgggcggca  540
cgtgactga  ctcattcga  actacaaca  cagtcgcga  gacagcctg  aggatgcct  600
ggactacgt  caggctcag  tgaagtgct  cggctgggt  agcttctac  actggacag  660
caacgctga  ctcatgaat  gccctgagg  cacctaccc  tgttcctgc  aagtcaagg  720
ggaagagga  aacagcctt  ctgtgagga  gggcttctg  gaggccccc  gcaacagga  780
ccagagtgg  aaccaccct  aggactggc  tgtgtacca  gagggctgc  tggagaagg  840
gcaggcgtg  ctgcaggag  acctgggca  catcctcgg  gtgggcgtg  gtgtggcca  900
catcgagct  ctggggatg  tcctgtcca  ctgcttgtg  cggcacgtc  attccgaag  960
ctacagcaa  gtccccaag  actgaggca  ctgctatcc  catctccct  cctggcccc  1020
aacctcagg  ctcccaggg  tctccctgg  tccctcctc  aggcctgcc  cccacttca  1080
tgcgaagac  ctcttgccc  ccctgactg  aagtagggg  ctttctggg  cctagcgat  1140
tctcctggc  tatccgctg  cagccttga  ccctggctg  tctgtggtt  ctctgctca  1200
cgcccatca  ggttctctt  tcaactcag  gaaaaatgc  ccccacagc  tccctggcg  1260
aggtgggct  gacttctac  tgccctcaa  ggtgtgtat  ttgtatagg  gcaactgta  1320
gaaaaattg  ggaggaggg  gccgggcgc  gtgctcacg  ctgtaatcc  agcactttg  1380
gaggccgag  cgggtggat  acgaggtca  gagatcgag  ccatcctgg  taacatggt  1440
aaaccccgt  tctactaaa  atacaaaaa  aatttagcc  ggcgcggtg  cgggcacct  1500
tagtcccag  tacttggga  gctgaggca  gagaatggt  tgaacccgg  agcggaggt  1560
gcagtgagc  gagatcgtg  tactgcact  cagcctggg  gacagaaag  gactccgtc  1620
caa  1623



<210> 7194
<211> 267
<212> PRT
<213> Homo sapiens
<308> P27701
<400> 7194

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
  1               5                  10                  15
Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
             20                  25                  30
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
         35                  40                  45
Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
     50                  55                  60
Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
 65                  70                  75                  80
Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                 85                  90                  95
Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
             100                105                110
Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
         115                120                125
Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
     130                135                140
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
 145                150                155                160
Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                 165                170                175
Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
             180                185                190
Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
         195                200                205
Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
     210                215                220
Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
 225                230                235                240
Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                 245                250                255
His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
             260                265



<210> 7195
<211> 582
<212> DNA
<213> Rattus norvegicus
<308> AI231213
<400> 7195

ggattgtta  aaatcctcc  ttaatagtt  atttcagag  tgagcatat  gaaaccctc  60
cccaccctg  aaggcacag  ctcacccac  cttagccca  gggacaggg  acagctgcc  120
agaaatacc  gtccagatc  tccttctct  gtccagaca  ctcagggtc  tatgccaga  180
ctgagggac  catgcccct  agctgtcag  tccctcacc  aggaaaagc  cactggggg  240
tacctgggc  agtccccca  gcagcctct  cgttcagtt  cctgctgaa  tgagcttgg  300
gggagtatt  caagtgtgt  caagaactg  ctaccctgt  tcccacaga  acattgaaa  360
cccataaag  aagtgtcac  gtggggaaa  cactaacct  tcctgtggc  tttccctgg  420
cagccatgg  tgctagccc  ccctccctg  tttttaata  tatattgtt  taatatgac  480
tcagggtgg  gacccagct  tcctgtgta  agtaatact  ggagccatt  caagctgtt  540
aaaatattc  aggcagtag  aggaagagc  acaggacag  aa  582



<210> 7196
<211> 266
<212> PRT
<213> Rattus norvegicus
<308> O70352
<400> 7196

Met Gly Ala Gly Cys Val Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
  1               5                  10                  15
Asn Leu Leu Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
             20                  25                  30
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
         35                  40                  45
Ser Ser Ser Leu Gln Val Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
     50                  55                  60
Ile Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
 65                  70                  75                  80
Val Arg Cys Leu Leu Gly Leu Tyr Phe Val Phe Leu Leu Leu Ile Leu 
                 85                  90                  95
Ile Ala Gln Val Thr Val Glu Val Leu Phe Tyr Phe Asn Ala Asn Lys 
             100                105                110
Leu Lys Gln Glu Met Gly Asn Thr Val Met Asp Ile Ile Gln Asn Tyr 
         115                120                125
Ser Val Asn Ala Ser Ser Ser Arg Glu Glu Ala Trp Asp Tyr Val Gln 
     130                135                140
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Pro Ser Asn Trp Thr Arg 
 145                150                155                160
Asn Pro Val Leu Lys Asn Ser Thr Lys Thr Thr Tyr Pro Cys Ser Cys 
                 165                170                175
Glu Lys Thr Lys Glu Glu Asp Asn Gln Leu Ile Val Lys Lys Gly Phe 
             180                185                190
Cys Glu Ser Asp Asn Ser Thr Ala Ser Glu Asn Ser Pro Glu Asp Trp 
         195                200                205
Pro Val His Pro Glu Gly Cys Met Glu Lys Ala Gln Ala Trp Leu Gln 
     210                215                220
Glu Asn Phe Gly Ile Leu Leu Gly Val Cys Ala Gly Val Ala Val Ile 
 225                230                235                240
Glu Leu Leu Gly Leu Phe Leu Ser Ile Cys Leu Cys Arg Tyr Ile His 
                 245                250                255
Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
             260                265



<210> 7197
<211> 1623
<212> DNA
<213> Homo sapiens
<308> NM_002231
<400> 7197

gctgtgcag  ccgacgccg  ctgaggcac  agcgggtga  gctgggcct  cagcgcgga  60
cagaaagca  aacccgcag  gtcctccct  ctgctgtgt  gacgacacg  gggcacagg  120
agaagtggg  cctgtgacc  gctgcactg  tttcgtgga  ggaagctcc  ggactggcg  180
gatgggctc  gcctgtatc  aagtcacca  atactttct  ttcctcttc  acttgatct  240
ctttatcct  ggcgcagtg  tcctgggct  cggggtgtg  atcctggcc  acaagagca  300
tttcatctc  gtcctgcaa  cctcctcca  ctcgcttag  atgggggcc  atgtcttca  360
cggcgtggg  gcagtcact  tgctcatgg  cttcctggg  tgcatcggc  ccgtcaacg  420
ggtccgctg  ctgctgggg  tgtactttg  tttcctgct  ctgatcctc  ttgcccagg  480
gacggccgg  gccctcttc  acttcaaca  gggcaagct  aagcaggag  tgggcggca  540
cgtgactga  ctcattcga  actacaaca  cagtcgcga  gacagcctg  aggatgcct  600
ggactacgt  caggctcag  tgaagtgct  cggctgggt  agcttctac  actggacag  660
caacgctga  ctcatgaat  gccctgagg  cacctaccc  tgttcctgc  aagtcaagg  720
ggaagagga  aacagcctt  ctgtgagga  gggcttctg  gaggccccc  gcaacagga  780
ccagagtgg  aaccaccct  aggactggc  tgtgtacca  gagggctgc  tggagaagg  840
gcaggcgtg  ctgcaggag  acctgggca  catcctcgg  gtgggcgtg  gtgtggcca  900
catcgagct  ctggggatg  tcctgtcca  ctgcttgtg  cggcacgtc  attccgaag  960
ctacagcaa  gtccccaag  actgaggca  ctgctatcc  catctccct  cctggcccc  1020
aacctcagg  ctcccaggg  tctccctgg  tccctcctc  aggcctgcc  cccacttca  1080
tgcgaagac  ctcttgccc  ccctgactg  aagtagggg  ctttctggg  cctagcgat  1140
tctcctggc  tatccgctg  cagccttga  ccctggctg  tctgtggtt  ctctgctca  1200
cgcccatca  ggttctctt  tcaactcag  gaaaaatgc  ccccacagc  tccctggcg  1260
aggtgggct  gacttctac  tgccctcaa  ggtgtgtat  ttgtatagg  gcaactgta  1320
gaaaaattg  ggaggaggg  gccgggcgc  gtgctcacg  ctgtaatcc  agcactttg  1380
gaggccgag  cgggtggat  acgaggtca  gagatcgag  ccatcctgg  taacatggt  1440
aaaccccgt  tctactaaa  atacaaaaa  aatttagcc  ggcgcggtg  cgggcacct  1500
tagtcccag  tacttggga  gctgaggca  gagaatggt  tgaacccgg  agcggaggt  1560
gcagtgagc  gagatcgtg  tactgcact  cagcctggg  gacagaaag  gactccgtc  1620
caa  1623



<210> 7198
<211> 267
<212> PRT
<213> Homo sapiens
<308> P27701
<400> 7198

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
  1               5                  10                  15
Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
             20                  25                  30
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
         35                  40                  45
Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
     50                  55                  60
Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
 65                  70                  75                  80
Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                 85                  90                  95
Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
             100                105                110
Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
         115                120                125
Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
     130                135                140
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
 145                150                155                160
Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                 165                170                175
Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
             180                185                190
Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
         195                200                205
Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
     210                215                220
Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
 225                230                235                240
Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                 245                250                255
His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
             260                265



<210> 7199
<211> 659
<212> DNA
<213> Rattus norvegicus
<308> AI231292
<400> 7199

tgttttttt  ttttttttt  ttttttttc  ttttttaaa  tttttaatt  agcaagagc  60
aggtatgac  ggtactgca  ggagaagag  accagggga  agctgttct  acgtgcaga  120
cctgcctgc  gcagcttct  tactgtctc  tggtgggaa  accccggag  tgccctcca  180
agctggagc  cccttctca  ggataaaac  ctacagggt  ggggaacaa  taagggacc  240
ttggcatgg  cctatgaga  tcagctctt  ggcattttt  cagctggat  ttgtcaggg  300
gtgtgtgcc  ttccagggc  cgctgtaga  ctggaagga  cagagtgcc  tcctcatca  360
atggggctg  tcgtggaaa  gacagttag  caaatttgt  tgggacttg  tacatgtag  420
tcggcccat  tccacatcc  aataatagt  tattccagc  acaagctgc  tacgagctc  480
caccacctg  atggcgcgg  tgtggtacg  atcgttgct  cccttgttg  actcgctta  540
ggcgaagtc  aacgctcgc  gcacgccct  ctcgctggc  tctgcctcc  gcggagctc  600
caacaatcg  gggggtggc  tgtaagttc  ggcccaggc  acggccagg  cggccagca  659



<210> 7200
<211> 127
<212> PRT
<213> Rattus norvegicus
<308> P14841
<400> 7200

Val Leu Ala Val Ala Trp Ala Gly Thr Ser Arg Pro Pro Pro Arg Leu 
  1               5                  10                  15
Leu Gly Ala Pro Gln Glu Ala Asp Ala Ser Glu Glu Gly Val Gln Arg 
             20                  25                  30
Ala Leu Asp Phe Ala Val Ser Glu Tyr Asn Lys Gly Ser Asn Asp Ala 
         35                  40                  45
Tyr His Ser Arg Ala Ile Gln Val Val Arg Ala Arg Lys Gln Leu Val 
     50                  55                  60
Ala Gly Ile Asn Tyr Tyr Leu Asp Val Glu Met Gly Arg Thr Thr Cys 
 65                  70                  75                  80
Thr Lys Ser Gln Thr Asn Leu Thr Asn Cys Pro Phe His Asp Gln Pro 
                 85                  90                  95
His Leu Met Arg Lys Ala Leu Cys Ser Phe Gln Ile Tyr Ser Val Pro 
             100                105                110
Trp Lys Gly Thr His Thr Leu Thr Lys Ser Ser Cys Lys Asn Ala 
         115                120                125



<210> 7201
<211> 818
<212> DNA
<213> Homo sapiens
<308> NM_000099
<400> 7201

cgcagcggg  cctctctat  tagctccag  ctctcgcct  cgccccact  cccgcgtcc  60
gcgtcctag  cgaccatgg  cgggcccct  cgcgccccg  tgctcctgc  ggccatcct  120
gccgtggcc  tggccgtga  ccccgcggc  ggctccagt  ccggcaagc  gccgcgcct  180
gtgggaggc  ccatggacg  cagcgtgga  gaggagggt  tgcggcgtg  actggactt  240
gccgtcggc  agtacaaca  agccagcaa  gacatgtac  acagccgcg  gctgcaggt  300
gtgcgcgcc  gcaagcaga  cgtagctgg  gtgaactac  tcttggacg  ggagctggg  360
cgaaccacg  gtaccaaga  ccagcccaa  ttggacaac  gccccttcc  tgaccagcc  420
catctgaaa  ggaaagcat  ctgctcttt  cagatctac  ctgtgcctt  gcagggcac  480
atgaccttg  cgaaatcca  ctgtcagga  gcctagggg  ctgtaccgg  ctggcctgt  540
cctatcacc  cttatgcac  cctcccacc  cctgtattc  cacccctgg  ctggtggcc  600
ctgccttgg  gaaggtctc  ccatgtgcc  gcaccagga  acagacaga  aaggcagca  660
gcggccttt  ttgctcagc  aggggctct  ccctccctc  ttccttctt  cttctcata  720
ccccggtgt  cggtgcata  acccccacc  cctgcaata  aatagtagc  tcggcaaaa  780
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  818



<210> 7202
<211> 146
<212> PRT
<213> Homo sapiens
<308> P01034
<400> 7202

Met Ala Gly Pro Leu Arg Ala Pro Leu Leu Leu Leu Ala Ile Leu Ala 
  1               5                  10                  15
Val Ala Leu Ala Val Ser Pro Ala Ala Gly Ser Ser Pro Gly Lys Pro 
             20                  25                  30
Pro Arg Leu Val Gly Gly Pro Met Asp Ala Ser Val Glu Glu Glu Gly 
         35                  40                  45
Val Arg Arg Ala Leu Asp Phe Ala Val Gly Glu Tyr Asn Lys Ala Ser 
     50                  55                  60
Asn Asp Met Tyr His Ser Arg Ala Leu Gln Val Val Arg Ala Arg Lys 
 65                  70                  75                  80
Gln Ile Val Ala Gly Val Asn Tyr Phe Leu Asp Val Glu Leu Gly Arg 
                 85                  90                  95
Thr Thr Cys Thr Lys Thr Gln Pro Asn Leu Asp Asn Cys Pro Phe His 
             100                105                110
Asp Gln Pro His Leu Lys Arg Lys Ala Phe Cys Ser Phe Gln Ile Tyr 
         115                120                125
Ala Val Pro Trp Gln Gly Thr Met Thr Leu Ser Lys Ser Thr Cys Gln 
     130                135                140
Asp Ala 
 145



<210> 7203
<211> 659
<212> DNA
<213> Rattus norvegicus
<308> AI231292
<400> 7203

tgttttttt  ttttttttt  ttttttttc  ttttttaaa  tttttaatt  agcaagagc  60
aggtatgac  ggtactgca  ggagaagag  accagggga  agctgttct  acgtgcaga  120
cctgcctgc  gcagcttct  tactgtctc  tggtgggaa  accccggag  tgccctcca  180
agctggagc  cccttctca  ggataaaac  ctacagggt  ggggaacaa  taagggacc  240
ttggcatgg  cctatgaga  tcagctctt  ggcattttt  cagctggat  ttgtcaggg  300
gtgtgtgcc  ttccagggc  cgctgtaga  ctggaagga  cagagtgcc  tcctcatca  360
atggggctg  tcgtggaaa  gacagttag  caaatttgt  tgggacttg  tacatgtag  420
tcggcccat  tccacatcc  aataatagt  tattccagc  acaagctgc  tacgagctc  480
caccacctg  atggcgcgg  tgtggtacg  atcgttgct  cccttgttg  actcgctta  540
ggcgaagtc  aacgctcgc  gcacgccct  ctcgctggc  tctgcctcc  gcggagctc  600
caacaatcg  gggggtggc  tgtaagttc  ggcccaggc  acggccagg  cggccagca  659



<210> 7204
<211> 127
<212> PRT
<213> Rattus norvegicus
<308> P14841
<400> 7204

Val Leu Ala Val Ala Trp Ala Gly Thr Ser Arg Pro Pro Pro Arg Leu 
  1               5                  10                  15
Leu Gly Ala Pro Gln Glu Ala Asp Ala Ser Glu Glu Gly Val Gln Arg 
             20                  25                  30
Ala Leu Asp Phe Ala Val Ser Glu Tyr Asn Lys Gly Ser Asn Asp Ala 
         35                  40                  45
Tyr His Ser Arg Ala Ile Gln Val Val Arg Ala Arg Lys Gln Leu Val 
     50                  55                  60
Ala Gly Ile Asn Tyr Tyr Leu Asp Val Glu Met Gly Arg Thr Thr Cys 
 65                  70                  75                  80
Thr Lys Ser Gln Thr Asn Leu Thr Asn Cys Pro Phe His Asp Gln Pro 
                 85                  90                  95
His Leu Met Arg Lys Ala Leu Cys Ser Phe Gln Ile Tyr Ser Val Pro 
             100                105                110
Trp Lys Gly Thr His Thr Leu Thr Lys Ser Ser Cys Lys Asn Ala 
         115                120                125



<210> 7205
<211> 818
<212> DNA
<213> Homo sapiens
<308> NM_000099
<400> 7205

cgcagcggg  cctctctat  tagctccag  ctctcgcct  cgccccact  cccgcgtcc  60
gcgtcctag  cgaccatgg  cgggcccct  cgcgccccg  tgctcctgc  ggccatcct  120
gccgtggcc  tggccgtga  ccccgcggc  ggctccagt  ccggcaagc  gccgcgcct  180
gtgggaggc  ccatggacg  cagcgtgga  gaggagggt  tgcggcgtg  actggactt  240
gccgtcggc  agtacaaca  agccagcaa  gacatgtac  acagccgcg  gctgcaggt  300
gtgcgcgcc  gcaagcaga  cgtagctgg  gtgaactac  tcttggacg  ggagctggg  360
cgaaccacg  gtaccaaga  ccagcccaa  ttggacaac  gccccttcc  tgaccagcc  420
catctgaaa  ggaaagcat  ctgctcttt  cagatctac  ctgtgcctt  gcagggcac  480
atgaccttg  cgaaatcca  ctgtcagga  gcctagggg  ctgtaccgg  ctggcctgt  540
cctatcacc  cttatgcac  cctcccacc  cctgtattc  cacccctgg  ctggtggcc  600
ctgccttgg  gaaggtctc  ccatgtgcc  gcaccagga  acagacaga  aaggcagca  660
gcggccttt  ttgctcagc  aggggctct  ccctccctc  ttccttctt  cttctcata  720
ccccggtgt  cggtgcata  acccccacc  cctgcaata  aatagtagc  tcggcaaaa  780
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  818



<210> 7206
<211> 146
<212> PRT
<213> Homo sapiens
<308> P01034
<400> 7206

Met Ala Gly Pro Leu Arg Ala Pro Leu Leu Leu Leu Ala Ile Leu Ala 
  1               5                  10                  15
Val Ala Leu Ala Val Ser Pro Ala Ala Gly Ser Ser Pro Gly Lys Pro 
             20                  25                  30
Pro Arg Leu Val Gly Gly Pro Met Asp Ala Ser Val Glu Glu Glu Gly 
         35                  40                  45
Val Arg Arg Ala Leu Asp Phe Ala Val Gly Glu Tyr Asn Lys Ala Ser 
     50                  55                  60
Asn Asp Met Tyr His Ser Arg Ala Leu Gln Val Val Arg Ala Arg Lys 
 65                  70                  75                  80
Gln Ile Val Ala Gly Val Asn Tyr Phe Leu Asp Val Glu Leu Gly Arg 
                 85                  90                  95
Thr Thr Cys Thr Lys Thr Gln Pro Asn Leu Asp Asn Cys Pro Phe His 
             100                105                110
Asp Gln Pro His Leu Lys Arg Lys Ala Phe Cys Ser Phe Gln Ile Tyr 
         115                120                125
Ala Val Pro Trp Gln Gly Thr Met Thr Leu Ser Lys Ser Thr Cys Gln 
     130                135                140
Asp Ala 
 145



<210> 7207
<211> 521
<212> DNA
<213> Rattus norvegicus
<308> AI231354
<400> 7207

attaaataa  tttaattat  ttccttctg  aatacaaaa  acagaataa  tcataccat  60
aaagtgggt  aaatatgat  atatgatag  ggccaattc  tacacatga  ctatttttt  120
gtggacaga  accaaatta  taaagagga  taagagatt  ttctagaag  agaactacc  180
ggaagatta  ttggcatta  aatactgat  cccaaagtg  tacatgggc  agttcaagc  240
agcatttgt  gtcacatgc  tacgagtcc  cacagttac  catgatctg  caccaagga  300
accacacga  tggaaaaag  aactcggct  ttctaattg  tcacctgaa  tgatcttga  360
caaaatttc  aacagtgtg  tttcaactg  tggtaacgt  ttagaacag  gaaagttga  420
tctgccact  gcacactga  aaactggcc  tcgctttta  tgtcactca  gatgtagtg  480
catacagga  tccggagag  tggtacctt  ttcagatcc  t  521



<210> 7208
<211> 423
<212> PRT
<213> Rattus norvegicus
<308> P49186
<400> 7208

Met Ser Asp Ser Lys Ser Asp Gly Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Lys Ala 
     370                375                380
Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser Thr 
 385                390                395                400
Glu His Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser Thr 
                 405                410                415
Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7209
<211> 1782
<212> DNA
<213> Homo sapiens
<308> L31951
<400> 7209

gggcgggcg  gggatctga  acttgccca  ccttcggga  attgcagga  gctgcatca  60
gagcgacag  aaatgtgac  gtcagtttt  tagtgtgca  gtggcagac  caaccttca  120
tgtcctaaa  cgttaccag  agctgaaac  aattggctc  ggggcccaa  ggattgttt  180
tgctgcatt  gatacagtt  ttgggataa  tgttgcagt  aagaaacta  gccgtcctt  240
tcagaacca  actcatgca  agagagctt  tcgtgaact  gtcctctta  aatgtgtca  300
tcataaaaa  ataattagt  tgttaaatg  gtttacacc  caaaaaact  tagaagaat  360
tcaagatgt  tatttggtt  tggaattaa  ggatgctaa  ttatgtcag  ttattcaca  420
ggagctgga  catgaaaga  tgtcctacc  tctttacca  atgctttgt  gtattaaac  480
tctgcattc  gctggtata  ttcatagag  tttgaagcc  agcaacatt  ttgtgaaat  540
agactgcac  ctgaagatc  ttgactttg  cctggcccg  acagcgtgc  ctaacttca  600
gatgacccc  tacgtggtg  cacggtact  ccgggcgcc  gaagtcatc  tgggtatgg  660
ctacaaaga  aacgttgat  tctggtcag  gggttgcat  atgggagag  tggtgaaag  720
ttgtgtgat  ttccaaggc  ctgaccata  tgatcagtg  aataaagtt  ttgagcagc  780
gggaacacc  tcagcagag  tcatgaaga  acttcagcc  actgtgagg  attatgtcg  840
aaacagacc  aagtatcct  gaatcaaat  tgaagaact  tttccagat  ggatattcc  900
atcagaatc  gagcgagac  aaataaaaa  aagtcaagc  agagatctg  tatcaaaaa  960
gttagtgat  gatcctgac  agcggatct  tgtagacga  gctctgcgt  acccataca  1020
cactgtttg  tatgacccc  ccgaagcag  agccccacc  cctcaaatt  atgatgccc  1080
gttggaaga  agagaacat  caattgaag  atggaaaga  ctaatttac  aagaagtca  1140
ggattggga  gaaagaagc  agaatggtg  tgtaaaaga  cagccttca  atgcagcag  1200
aagtagcaa  gccactcct  ctcagtctt  atcgatcaa  gacatttca  ccatgtcca  1260
tgagcagac  ctggcctca  acacagaca  cagtcttga  gcctcgacg  gaccccttg  1320
aggctgtcg  tgataggtt  gaaatagca  acctgtcag  attgaagga  ctctcacct  1380
cgtgggcct  aaatgcttg  gagttgatg  aaccaaata  aaaaactcc  tgttctgca  1440
gtaagaaac  caatgcctt  ccctattca  acctgatag  attgcctgc  tagatgata  1500
aatgaggca  aatatgtct  aagaaaaaa  ttgcaagcc  cacttctag  gattttgtt  1560
aagatcatt  caggtgagc  gttagagta  gtgaatttg  ttcaaattg  actagtgac  1620
gtttctcat  atctgtaac  gttgagatg  atgtgcatg  gaccacaaa  gcttgcttg  1680
acttgccca  ctagcactt  ggaaatcag  atttaaatg  caaataatc  tccaggtag  1740
gctgcttct  aagttatct  ttaatcctc  taagtaatt  gg  1782



<210> 7210
<211> 424
<212> PRT
<213> Homo sapiens
<308> P45984
<400> 7210

Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Ser Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Asn 
     370                375                380
Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser 
 385                390                395                400
Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser 
                 405                410                415
Thr Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7211
<211> 521
<212> DNA
<213> Rattus norvegicus
<308> AI231354
<400> 7211

attaaataa  tttaattat  ttccttctg  aatacaaaa  acagaataa  tcataccat  60
aaagtgggt  aaatatgat  atatgatag  ggccaattc  tacacatga  ctatttttt  120
gtggacaga  accaaatta  taaagagga  taagagatt  ttctagaag  agaactacc  180
ggaagatta  ttggcatta  aatactgat  cccaaagtg  tacatgggc  agttcaagc  240
agcatttgt  gtcacatgc  tacgagtcc  cacagttac  catgatctg  caccaagga  300
accacacga  tggaaaaag  aactcggct  ttctaattg  tcacctgaa  tgatcttga  360
caaaatttc  aacagtgtg  tttcaactg  tggtaacgt  ttagaacag  gaaagttga  420
tctgccact  gcacactga  aaactggcc  tcgctttta  tgtcactca  gatgtagtg  480
catacagga  tccggagag  tggtacctt  ttcagatcc  t  521



<210> 7212
<211> 423
<212> PRT
<213> Rattus norvegicus
<308> P49186
<400> 7212

Met Ser Asp Ser Lys Ser Asp Gly Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Lys Ala 
     370                375                380
Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser Thr 
 385                390                395                400
Glu His Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser Thr 
                 405                410                415
Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7213
<211> 1782
<212> DNA
<213> Homo sapiens
<308> L31951
<400> 7213

gggcgggcg  gggatctga  acttgccca  ccttcggga  attgcagga  gctgcatca  60
gagcgacag  aaatgtgac  gtcagtttt  tagtgtgca  gtggcagac  caaccttca  120
tgtcctaaa  cgttaccag  agctgaaac  aattggctc  ggggcccaa  ggattgttt  180
tgctgcatt  gatacagtt  ttgggataa  tgttgcagt  aagaaacta  gccgtcctt  240
tcagaacca  actcatgca  agagagctt  tcgtgaact  gtcctctta  aatgtgtca  300
tcataaaaa  ataattagt  tgttaaatg  gtttacacc  caaaaaact  tagaagaat  360
tcaagatgt  tatttggtt  tggaattaa  ggatgctaa  ttatgtcag  ttattcaca  420
ggagctgga  catgaaaga  tgtcctacc  tctttacca  atgctttgt  gtattaaac  480
tctgcattc  gctggtata  ttcatagag  tttgaagcc  agcaacatt  ttgtgaaat  540
agactgcac  ctgaagatc  ttgactttg  cctggcccg  acagcgtgc  ctaacttca  600
gatgacccc  tacgtggtg  cacggtact  ccgggcgcc  gaagtcatc  tgggtatgg  660
ctacaaaga  aacgttgat  tctggtcag  gggttgcat  atgggagag  tggtgaaag  720
ttgtgtgat  ttccaaggc  ctgaccata  tgatcagtg  aataaagtt  ttgagcagc  780
gggaacacc  tcagcagag  tcatgaaga  acttcagcc  actgtgagg  attatgtcg  840
aaacagacc  aagtatcct  gaatcaaat  tgaagaact  tttccagat  ggatattcc  900
atcagaatc  gagcgagac  aaataaaaa  aagtcaagc  agagatctg  tatcaaaaa  960
gttagtgat  gatcctgac  agcggatct  tgtagacga  gctctgcgt  acccataca  1020
cactgtttg  tatgacccc  ccgaagcag  agccccacc  cctcaaatt  atgatgccc  1080
gttggaaga  agagaacat  caattgaag  atggaaaga  ctaatttac  aagaagtca  1140
ggattggga  gaaagaagc  agaatggtg  tgtaaaaga  cagccttca  atgcagcag  1200
aagtagcaa  gccactcct  ctcagtctt  atcgatcaa  gacatttca  ccatgtcca  1260
tgagcagac  ctggcctca  acacagaca  cagtcttga  gcctcgacg  gaccccttg  1320
aggctgtcg  tgataggtt  gaaatagca  acctgtcag  attgaagga  ctctcacct  1380
cgtgggcct  aaatgcttg  gagttgatg  aaccaaata  aaaaactcc  tgttctgca  1440
gtaagaaac  caatgcctt  ccctattca  acctgatag  attgcctgc  tagatgata  1500
aatgaggca  aatatgtct  aagaaaaaa  ttgcaagcc  cacttctag  gattttgtt  1560
aagatcatt  caggtgagc  gttagagta  gtgaatttg  ttcaaattg  actagtgac  1620
gtttctcat  atctgtaac  gttgagatg  atgtgcatg  gaccacaaa  gcttgcttg  1680
acttgccca  ctagcactt  ggaaatcag  atttaaatg  caaataatc  tccaggtag  1740
gctgcttct  aagttatct  ttaatcctc  taagtaatt  gg  1782



<210> 7214
<211> 424
<212> PRT
<213> Homo sapiens
<308> P45984
<400> 7214

Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Ser Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Asn 
     370                375                380
Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser 
 385                390                395                400
Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser 
                 405                410                415
Thr Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7215
<211> 521
<212> DNA
<213> Rattus norvegicus
<308> AI231354
<400> 7215

attaaataa  tttaattat  ttccttctg  aatacaaaa  acagaataa  tcataccat  60
aaagtgggt  aaatatgat  atatgatag  ggccaattc  tacacatga  ctatttttt  120
gtggacaga  accaaatta  taaagagga  taagagatt  ttctagaag  agaactacc  180
ggaagatta  ttggcatta  aatactgat  cccaaagtg  tacatgggc  agttcaagc  240
agcatttgt  gtcacatgc  tacgagtcc  cacagttac  catgatctg  caccaagga  300
accacacga  tggaaaaag  aactcggct  ttctaattg  tcacctgaa  tgatcttga  360
caaaatttc  aacagtgtg  tttcaactg  tggtaacgt  ttagaacag  gaaagttga  420
tctgccact  gcacactga  aaactggcc  tcgctttta  tgtcactca  gatgtagtg  480
catacagga  tccggagag  tggtacctt  ttcagatcc  t  521



<210> 7216
<211> 423
<212> PRT
<213> Rattus norvegicus
<308> P49186
<400> 7216

Met Ser Asp Ser Lys Ser Asp Gly Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Lys Ala 
     370                375                380
Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser Thr 
 385                390                395                400
Glu His Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser Thr 
                 405                410                415
Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7217
<211> 1782
<212> DNA
<213> Homo sapiens
<308> L31951
<400> 7217

gggcgggcg  gggatctga  acttgccca  ccttcggga  attgcagga  gctgcatca  60
gagcgacag  aaatgtgac  gtcagtttt  tagtgtgca  gtggcagac  caaccttca  120
tgtcctaaa  cgttaccag  agctgaaac  aattggctc  ggggcccaa  ggattgttt  180
tgctgcatt  gatacagtt  ttgggataa  tgttgcagt  aagaaacta  gccgtcctt  240
tcagaacca  actcatgca  agagagctt  tcgtgaact  gtcctctta  aatgtgtca  300
tcataaaaa  ataattagt  tgttaaatg  gtttacacc  caaaaaact  tagaagaat  360
tcaagatgt  tatttggtt  tggaattaa  ggatgctaa  ttatgtcag  ttattcaca  420
ggagctgga  catgaaaga  tgtcctacc  tctttacca  atgctttgt  gtattaaac  480
tctgcattc  gctggtata  ttcatagag  tttgaagcc  agcaacatt  ttgtgaaat  540
agactgcac  ctgaagatc  ttgactttg  cctggcccg  acagcgtgc  ctaacttca  600
gatgacccc  tacgtggtg  cacggtact  ccgggcgcc  gaagtcatc  tgggtatgg  660
ctacaaaga  aacgttgat  tctggtcag  gggttgcat  atgggagag  tggtgaaag  720
ttgtgtgat  ttccaaggc  ctgaccata  tgatcagtg  aataaagtt  ttgagcagc  780
gggaacacc  tcagcagag  tcatgaaga  acttcagcc  actgtgagg  attatgtcg  840
aaacagacc  aagtatcct  gaatcaaat  tgaagaact  tttccagat  ggatattcc  900
atcagaatc  gagcgagac  aaataaaaa  aagtcaagc  agagatctg  tatcaaaaa  960
gttagtgat  gatcctgac  agcggatct  tgtagacga  gctctgcgt  acccataca  1020
cactgtttg  tatgacccc  ccgaagcag  agccccacc  cctcaaatt  atgatgccc  1080
gttggaaga  agagaacat  caattgaag  atggaaaga  ctaatttac  aagaagtca  1140
ggattggga  gaaagaagc  agaatggtg  tgtaaaaga  cagccttca  atgcagcag  1200
aagtagcaa  gccactcct  ctcagtctt  atcgatcaa  gacatttca  ccatgtcca  1260
tgagcagac  ctggcctca  acacagaca  cagtcttga  gcctcgacg  gaccccttg  1320
aggctgtcg  tgataggtt  gaaatagca  acctgtcag  attgaagga  ctctcacct  1380
cgtgggcct  aaatgcttg  gagttgatg  aaccaaata  aaaaactcc  tgttctgca  1440
gtaagaaac  caatgcctt  ccctattca  acctgatag  attgcctgc  tagatgata  1500
aatgaggca  aatatgtct  aagaaaaaa  ttgcaagcc  cacttctag  gattttgtt  1560
aagatcatt  caggtgagc  gttagagta  gtgaatttg  ttcaaattg  actagtgac  1620
gtttctcat  atctgtaac  gttgagatg  atgtgcatg  gaccacaaa  gcttgcttg  1680
acttgccca  ctagcactt  ggaaatcag  atttaaatg  caaataatc  tccaggtag  1740
gctgcttct  aagttatct  ttaatcctc  taagtaatt  gg  1782



<210> 7218
<211> 424
<212> PRT
<213> Homo sapiens
<308> P45984
<400> 7218

Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Ser Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Asn 
     370                375                380
Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser 
 385                390                395                400
Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser 
                 405                410                415
Thr Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7219
<211> 521
<212> DNA
<213> Rattus norvegicus
<308> AI231354
<400> 7219

attaaataa  tttaattat  ttccttctg  aatacaaaa  acagaataa  tcataccat  60
aaagtgggt  aaatatgat  atatgatag  ggccaattc  tacacatga  ctatttttt  120
gtggacaga  accaaatta  taaagagga  taagagatt  ttctagaag  agaactacc  180
ggaagatta  ttggcatta  aatactgat  cccaaagtg  tacatgggc  agttcaagc  240
agcatttgt  gtcacatgc  tacgagtcc  cacagttac  catgatctg  caccaagga  300
accacacga  tggaaaaag  aactcggct  ttctaattg  tcacctgaa  tgatcttga  360
caaaatttc  aacagtgtg  tttcaactg  tggtaacgt  ttagaacag  gaaagttga  420
tctgccact  gcacactga  aaactggcc  tcgctttta  tgtcactca  gatgtagtg  480
catacagga  tccggagag  tggtacctt  ttcagatcc  t  521



<210> 7220
<211> 423
<212> PRT
<213> Rattus norvegicus
<308> P49186
<400> 7220

Met Ser Asp Ser Lys Ser Asp Gly Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Lys Ala 
     370                375                380
Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser Thr 
 385                390                395                400
Glu His Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser Thr 
                 405                410                415
Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7221
<211> 1782
<212> DNA
<213> Homo sapiens
<308> L31951
<400> 7221

gggcgggcg  gggatctga  acttgccca  ccttcggga  attgcagga  gctgcatca  60
gagcgacag  aaatgtgac  gtcagtttt  tagtgtgca  gtggcagac  caaccttca  120
tgtcctaaa  cgttaccag  agctgaaac  aattggctc  ggggcccaa  ggattgttt  180
tgctgcatt  gatacagtt  ttgggataa  tgttgcagt  aagaaacta  gccgtcctt  240
tcagaacca  actcatgca  agagagctt  tcgtgaact  gtcctctta  aatgtgtca  300
tcataaaaa  ataattagt  tgttaaatg  gtttacacc  caaaaaact  tagaagaat  360
tcaagatgt  tatttggtt  tggaattaa  ggatgctaa  ttatgtcag  ttattcaca  420
ggagctgga  catgaaaga  tgtcctacc  tctttacca  atgctttgt  gtattaaac  480
tctgcattc  gctggtata  ttcatagag  tttgaagcc  agcaacatt  ttgtgaaat  540
agactgcac  ctgaagatc  ttgactttg  cctggcccg  acagcgtgc  ctaacttca  600
gatgacccc  tacgtggtg  cacggtact  ccgggcgcc  gaagtcatc  tgggtatgg  660
ctacaaaga  aacgttgat  tctggtcag  gggttgcat  atgggagag  tggtgaaag  720
ttgtgtgat  ttccaaggc  ctgaccata  tgatcagtg  aataaagtt  ttgagcagc  780
gggaacacc  tcagcagag  tcatgaaga  acttcagcc  actgtgagg  attatgtcg  840
aaacagacc  aagtatcct  gaatcaaat  tgaagaact  tttccagat  ggatattcc  900
atcagaatc  gagcgagac  aaataaaaa  aagtcaagc  agagatctg  tatcaaaaa  960
gttagtgat  gatcctgac  agcggatct  tgtagacga  gctctgcgt  acccataca  1020
cactgtttg  tatgacccc  ccgaagcag  agccccacc  cctcaaatt  atgatgccc  1080
gttggaaga  agagaacat  caattgaag  atggaaaga  ctaatttac  aagaagtca  1140
ggattggga  gaaagaagc  agaatggtg  tgtaaaaga  cagccttca  atgcagcag  1200
aagtagcaa  gccactcct  ctcagtctt  atcgatcaa  gacatttca  ccatgtcca  1260
tgagcagac  ctggcctca  acacagaca  cagtcttga  gcctcgacg  gaccccttg  1320
aggctgtcg  tgataggtt  gaaatagca  acctgtcag  attgaagga  ctctcacct  1380
cgtgggcct  aaatgcttg  gagttgatg  aaccaaata  aaaaactcc  tgttctgca  1440
gtaagaaac  caatgcctt  ccctattca  acctgatag  attgcctgc  tagatgata  1500
aatgaggca  aatatgtct  aagaaaaaa  ttgcaagcc  cacttctag  gattttgtt  1560
aagatcatt  caggtgagc  gttagagta  gtgaatttg  ttcaaattg  actagtgac  1620
gtttctcat  atctgtaac  gttgagatg  atgtgcatg  gaccacaaa  gcttgcttg  1680
acttgccca  ctagcactt  ggaaatcag  atttaaatg  caaataatc  tccaggtag  1740
gctgcttct  aagttatct  ttaatcctc  taagtaatt  gg  1782



<210> 7222
<211> 424
<212> PRT
<213> Homo sapiens
<308> P45984
<400> 7222

Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Ser Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Asn 
     370                375                380
Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser 
 385                390                395                400
Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser 
                 405                410                415
Thr Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7223
<211> 521
<212> DNA
<213> Rattus norvegicus
<308> AI231354
<400> 7223

attaaataa  tttaattat  ttccttctg  aatacaaaa  acagaataa  tcataccat  60
aaagtgggt  aaatatgat  atatgatag  ggccaattc  tacacatga  ctatttttt  120
gtggacaga  accaaatta  taaagagga  taagagatt  ttctagaag  agaactacc  180
ggaagatta  ttggcatta  aatactgat  cccaaagtg  tacatgggc  agttcaagc  240
agcatttgt  gtcacatgc  tacgagtcc  cacagttac  catgatctg  caccaagga  300
accacacga  tggaaaaag  aactcggct  ttctaattg  tcacctgaa  tgatcttga  360
caaaatttc  aacagtgtg  tttcaactg  tggtaacgt  ttagaacag  gaaagttga  420
tctgccact  gcacactga  aaactggcc  tcgctttta  tgtcactca  gatgtagtg  480
catacagga  tccggagag  tggtacctt  ttcagatcc  t  521



<210> 7224
<211> 423
<212> PRT
<213> Rattus norvegicus
<308> P49186
<400> 7224

Met Ser Asp Ser Lys Ser Asp Gly Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Lys Ala 
     370                375                380
Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser Thr 
 385                390                395                400
Glu His Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser Thr 
                 405                410                415
Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7225
<211> 1782
<212> DNA
<213> Homo sapiens
<308> L31951
<400> 7225

gggcgggcg  gggatctga  acttgccca  ccttcggga  attgcagga  gctgcatca  60
gagcgacag  aaatgtgac  gtcagtttt  tagtgtgca  gtggcagac  caaccttca  120
tgtcctaaa  cgttaccag  agctgaaac  aattggctc  ggggcccaa  ggattgttt  180
tgctgcatt  gatacagtt  ttgggataa  tgttgcagt  aagaaacta  gccgtcctt  240
tcagaacca  actcatgca  agagagctt  tcgtgaact  gtcctctta  aatgtgtca  300
tcataaaaa  ataattagt  tgttaaatg  gtttacacc  caaaaaact  tagaagaat  360
tcaagatgt  tatttggtt  tggaattaa  ggatgctaa  ttatgtcag  ttattcaca  420
ggagctgga  catgaaaga  tgtcctacc  tctttacca  atgctttgt  gtattaaac  480
tctgcattc  gctggtata  ttcatagag  tttgaagcc  agcaacatt  ttgtgaaat  540
agactgcac  ctgaagatc  ttgactttg  cctggcccg  acagcgtgc  ctaacttca  600
gatgacccc  tacgtggtg  cacggtact  ccgggcgcc  gaagtcatc  tgggtatgg  660
ctacaaaga  aacgttgat  tctggtcag  gggttgcat  atgggagag  tggtgaaag  720
ttgtgtgat  ttccaaggc  ctgaccata  tgatcagtg  aataaagtt  ttgagcagc  780
gggaacacc  tcagcagag  tcatgaaga  acttcagcc  actgtgagg  attatgtcg  840
aaacagacc  aagtatcct  gaatcaaat  tgaagaact  tttccagat  ggatattcc  900
atcagaatc  gagcgagac  aaataaaaa  aagtcaagc  agagatctg  tatcaaaaa  960
gttagtgat  gatcctgac  agcggatct  tgtagacga  gctctgcgt  acccataca  1020
cactgtttg  tatgacccc  ccgaagcag  agccccacc  cctcaaatt  atgatgccc  1080
gttggaaga  agagaacat  caattgaag  atggaaaga  ctaatttac  aagaagtca  1140
ggattggga  gaaagaagc  agaatggtg  tgtaaaaga  cagccttca  atgcagcag  1200
aagtagcaa  gccactcct  ctcagtctt  atcgatcaa  gacatttca  ccatgtcca  1260
tgagcagac  ctggcctca  acacagaca  cagtcttga  gcctcgacg  gaccccttg  1320
aggctgtcg  tgataggtt  gaaatagca  acctgtcag  attgaagga  ctctcacct  1380
cgtgggcct  aaatgcttg  gagttgatg  aaccaaata  aaaaactcc  tgttctgca  1440
gtaagaaac  caatgcctt  ccctattca  acctgatag  attgcctgc  tagatgata  1500
aatgaggca  aatatgtct  aagaaaaaa  ttgcaagcc  cacttctag  gattttgtt  1560
aagatcatt  caggtgagc  gttagagta  gtgaatttg  ttcaaattg  actagtgac  1620
gtttctcat  atctgtaac  gttgagatg  atgtgcatg  gaccacaaa  gcttgcttg  1680
acttgccca  ctagcactt  ggaaatcag  atttaaatg  caaataatc  tccaggtag  1740
gctgcttct  aagttatct  ttaatcctc  taagtaatt  gg  1782



<210> 7226
<211> 424
<212> PRT
<213> Homo sapiens
<308> P45984
<400> 7226

Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Ser Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Asn 
     370                375                380
Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser 
 385                390                395                400
Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser 
                 405                410                415
Thr Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7227
<211> 521
<212> DNA
<213> Rattus norvegicus
<308> AI231354
<400> 7227

attaaataa  tttaattat  ttccttctg  aatacaaaa  acagaataa  tcataccat  60
aaagtgggt  aaatatgat  atatgatag  ggccaattc  tacacatga  ctatttttt  120
gtggacaga  accaaatta  taaagagga  taagagatt  ttctagaag  agaactacc  180
ggaagatta  ttggcatta  aatactgat  cccaaagtg  tacatgggc  agttcaagc  240
agcatttgt  gtcacatgc  tacgagtcc  cacagttac  catgatctg  caccaagga  300
accacacga  tggaaaaag  aactcggct  ttctaattg  tcacctgaa  tgatcttga  360
caaaatttc  aacagtgtg  tttcaactg  tggtaacgt  ttagaacag  gaaagttga  420
tctgccact  gcacactga  aaactggcc  tcgctttta  tgtcactca  gatgtagtg  480
catacagga  tccggagag  tggtacctt  ttcagatcc  t  521



<210> 7228
<211> 423
<212> PRT
<213> Rattus norvegicus
<308> P49186
<400> 7228

Met Ser Asp Ser Lys Ser Asp Gly Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Lys Ala 
     370                375                380
Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser Thr 
 385                390                395                400
Glu His Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser Thr 
                 405                410                415
Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7229
<211> 1782
<212> DNA
<213> Homo sapiens
<308> L31951
<400> 7229

gggcgggcg  gggatctga  acttgccca  ccttcggga  attgcagga  gctgcatca  60
gagcgacag  aaatgtgac  gtcagtttt  tagtgtgca  gtggcagac  caaccttca  120
tgtcctaaa  cgttaccag  agctgaaac  aattggctc  ggggcccaa  ggattgttt  180
tgctgcatt  gatacagtt  ttgggataa  tgttgcagt  aagaaacta  gccgtcctt  240
tcagaacca  actcatgca  agagagctt  tcgtgaact  gtcctctta  aatgtgtca  300
tcataaaaa  ataattagt  tgttaaatg  gtttacacc  caaaaaact  tagaagaat  360
tcaagatgt  tatttggtt  tggaattaa  ggatgctaa  ttatgtcag  ttattcaca  420
ggagctgga  catgaaaga  tgtcctacc  tctttacca  atgctttgt  gtattaaac  480
tctgcattc  gctggtata  ttcatagag  tttgaagcc  agcaacatt  ttgtgaaat  540
agactgcac  ctgaagatc  ttgactttg  cctggcccg  acagcgtgc  ctaacttca  600
gatgacccc  tacgtggtg  cacggtact  ccgggcgcc  gaagtcatc  tgggtatgg  660
ctacaaaga  aacgttgat  tctggtcag  gggttgcat  atgggagag  tggtgaaag  720
ttgtgtgat  ttccaaggc  ctgaccata  tgatcagtg  aataaagtt  ttgagcagc  780
gggaacacc  tcagcagag  tcatgaaga  acttcagcc  actgtgagg  attatgtcg  840
aaacagacc  aagtatcct  gaatcaaat  tgaagaact  tttccagat  ggatattcc  900
atcagaatc  gagcgagac  aaataaaaa  aagtcaagc  agagatctg  tatcaaaaa  960
gttagtgat  gatcctgac  agcggatct  tgtagacga  gctctgcgt  acccataca  1020
cactgtttg  tatgacccc  ccgaagcag  agccccacc  cctcaaatt  atgatgccc  1080
gttggaaga  agagaacat  caattgaag  atggaaaga  ctaatttac  aagaagtca  1140
ggattggga  gaaagaagc  agaatggtg  tgtaaaaga  cagccttca  atgcagcag  1200
aagtagcaa  gccactcct  ctcagtctt  atcgatcaa  gacatttca  ccatgtcca  1260
tgagcagac  ctggcctca  acacagaca  cagtcttga  gcctcgacg  gaccccttg  1320
aggctgtcg  tgataggtt  gaaatagca  acctgtcag  attgaagga  ctctcacct  1380
cgtgggcct  aaatgcttg  gagttgatg  aaccaaata  aaaaactcc  tgttctgca  1440
gtaagaaac  caatgcctt  ccctattca  acctgatag  attgcctgc  tagatgata  1500
aatgaggca  aatatgtct  aagaaaaaa  ttgcaagcc  cacttctag  gattttgtt  1560
aagatcatt  caggtgagc  gttagagta  gtgaatttg  ttcaaattg  actagtgac  1620
gtttctcat  atctgtaac  gttgagatg  atgtgcatg  gaccacaaa  gcttgcttg  1680
acttgccca  ctagcactt  ggaaatcag  atttaaatg  caaataatc  tccaggtag  1740
gctgcttct  aagttatct  ttaatcctc  taagtaatt  gg  1782



<210> 7230
<211> 424
<212> PRT
<213> Homo sapiens
<308> P45984
<400> 7230

Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Ser Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Asn 
     370                375                380
Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser 
 385                390                395                400
Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser 
                 405                410                415
Thr Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7231
<211> 521
<212> DNA
<213> Rattus norvegicus
<308> AI231354
<400> 7231

attaaataa  tttaattat  ttccttctg  aatacaaaa  acagaataa  tcataccat  60
aaagtgggt  aaatatgat  atatgatag  ggccaattc  tacacatga  ctatttttt  120
gtggacaga  accaaatta  taaagagga  taagagatt  ttctagaag  agaactacc  180
ggaagatta  ttggcatta  aatactgat  cccaaagtg  tacatgggc  agttcaagc  240
agcatttgt  gtcacatgc  tacgagtcc  cacagttac  catgatctg  caccaagga  300
accacacga  tggaaaaag  aactcggct  ttctaattg  tcacctgaa  tgatcttga  360
caaaatttc  aacagtgtg  tttcaactg  tggtaacgt  ttagaacag  gaaagttga  420
tctgccact  gcacactga  aaactggcc  tcgctttta  tgtcactca  gatgtagtg  480
catacagga  tccggagag  tggtacctt  ttcagatcc  t  521



<210> 7232
<211> 423
<212> PRT
<213> Rattus norvegicus
<308> P49186
<400> 7232

Met Ser Asp Ser Lys Ser Asp Gly Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Lys Ala 
     370                375                380
Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser Thr 
 385                390                395                400
Glu His Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser Thr 
                 405                410                415
Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7233
<211> 1782
<212> DNA
<213> Homo sapiens
<308> L31951
<400> 7233

gggcgggcg  gggatctga  acttgccca  ccttcggga  attgcagga  gctgcatca  60
gagcgacag  aaatgtgac  gtcagtttt  tagtgtgca  gtggcagac  caaccttca  120
tgtcctaaa  cgttaccag  agctgaaac  aattggctc  ggggcccaa  ggattgttt  180
tgctgcatt  gatacagtt  ttgggataa  tgttgcagt  aagaaacta  gccgtcctt  240
tcagaacca  actcatgca  agagagctt  tcgtgaact  gtcctctta  aatgtgtca  300
tcataaaaa  ataattagt  tgttaaatg  gtttacacc  caaaaaact  tagaagaat  360
tcaagatgt  tatttggtt  tggaattaa  ggatgctaa  ttatgtcag  ttattcaca  420
ggagctgga  catgaaaga  tgtcctacc  tctttacca  atgctttgt  gtattaaac  480
tctgcattc  gctggtata  ttcatagag  tttgaagcc  agcaacatt  ttgtgaaat  540
agactgcac  ctgaagatc  ttgactttg  cctggcccg  acagcgtgc  ctaacttca  600
gatgacccc  tacgtggtg  cacggtact  ccgggcgcc  gaagtcatc  tgggtatgg  660
ctacaaaga  aacgttgat  tctggtcag  gggttgcat  atgggagag  tggtgaaag  720
ttgtgtgat  ttccaaggc  ctgaccata  tgatcagtg  aataaagtt  ttgagcagc  780
gggaacacc  tcagcagag  tcatgaaga  acttcagcc  actgtgagg  attatgtcg  840
aaacagacc  aagtatcct  gaatcaaat  tgaagaact  tttccagat  ggatattcc  900
atcagaatc  gagcgagac  aaataaaaa  aagtcaagc  agagatctg  tatcaaaaa  960
gttagtgat  gatcctgac  agcggatct  tgtagacga  gctctgcgt  acccataca  1020
cactgtttg  tatgacccc  ccgaagcag  agccccacc  cctcaaatt  atgatgccc  1080
gttggaaga  agagaacat  caattgaag  atggaaaga  ctaatttac  aagaagtca  1140
ggattggga  gaaagaagc  agaatggtg  tgtaaaaga  cagccttca  atgcagcag  1200
aagtagcaa  gccactcct  ctcagtctt  atcgatcaa  gacatttca  ccatgtcca  1260
tgagcagac  ctggcctca  acacagaca  cagtcttga  gcctcgacg  gaccccttg  1320
aggctgtcg  tgataggtt  gaaatagca  acctgtcag  attgaagga  ctctcacct  1380
cgtgggcct  aaatgcttg  gagttgatg  aaccaaata  aaaaactcc  tgttctgca  1440
gtaagaaac  caatgcctt  ccctattca  acctgatag  attgcctgc  tagatgata  1500
aatgaggca  aatatgtct  aagaaaaaa  ttgcaagcc  cacttctag  gattttgtt  1560
aagatcatt  caggtgagc  gttagagta  gtgaatttg  ttcaaattg  actagtgac  1620
gtttctcat  atctgtaac  gttgagatg  atgtgcatg  gaccacaaa  gcttgcttg  1680
acttgccca  ctagcactt  ggaaatcag  atttaaatg  caaataatc  tccaggtag  1740
gctgcttct  aagttatct  ttaatcctc  taagtaatt  gg  1782



<210> 7234
<211> 424
<212> PRT
<213> Homo sapiens
<308> P45984
<400> 7234

Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Ser Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Asn 
     370                375                380
Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser 
 385                390                395                400
Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser 
                 405                410                415
Thr Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7235
<211> 521
<212> DNA
<213> Rattus norvegicus
<308> AI231354
<400> 7235

attaaataa  tttaattat  ttccttctg  aatacaaaa  acagaataa  tcataccat  60
aaagtgggt  aaatatgat  atatgatag  ggccaattc  tacacatga  ctatttttt  120
gtggacaga  accaaatta  taaagagga  taagagatt  ttctagaag  agaactacc  180
ggaagatta  ttggcatta  aatactgat  cccaaagtg  tacatgggc  agttcaagc  240
agcatttgt  gtcacatgc  tacgagtcc  cacagttac  catgatctg  caccaagga  300
accacacga  tggaaaaag  aactcggct  ttctaattg  tcacctgaa  tgatcttga  360
caaaatttc  aacagtgtg  tttcaactg  tggtaacgt  ttagaacag  gaaagttga  420
tctgccact  gcacactga  aaactggcc  tcgctttta  tgtcactca  gatgtagtg  480
catacagga  tccggagag  tggtacctt  ttcagatcc  t  521



<210> 7236
<211> 423
<212> PRT
<213> Rattus norvegicus
<308> P49186
<400> 7236

Met Ser Asp Ser Lys Ser Asp Gly Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Lys Ala 
     370                375                380
Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser Thr 
 385                390                395                400
Glu His Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser Thr 
                 405                410                415
Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7237
<211> 1782
<212> DNA
<213> Homo sapiens
<308> L31951
<400> 7237

gggcgggcg  gggatctga  acttgccca  ccttcggga  attgcagga  gctgcatca  60
gagcgacag  aaatgtgac  gtcagtttt  tagtgtgca  gtggcagac  caaccttca  120
tgtcctaaa  cgttaccag  agctgaaac  aattggctc  ggggcccaa  ggattgttt  180
tgctgcatt  gatacagtt  ttgggataa  tgttgcagt  aagaaacta  gccgtcctt  240
tcagaacca  actcatgca  agagagctt  tcgtgaact  gtcctctta  aatgtgtca  300
tcataaaaa  ataattagt  tgttaaatg  gtttacacc  caaaaaact  tagaagaat  360
tcaagatgt  tatttggtt  tggaattaa  ggatgctaa  ttatgtcag  ttattcaca  420
ggagctgga  catgaaaga  tgtcctacc  tctttacca  atgctttgt  gtattaaac  480
tctgcattc  gctggtata  ttcatagag  tttgaagcc  agcaacatt  ttgtgaaat  540
agactgcac  ctgaagatc  ttgactttg  cctggcccg  acagcgtgc  ctaacttca  600
gatgacccc  tacgtggtg  cacggtact  ccgggcgcc  gaagtcatc  tgggtatgg  660
ctacaaaga  aacgttgat  tctggtcag  gggttgcat  atgggagag  tggtgaaag  720
ttgtgtgat  ttccaaggc  ctgaccata  tgatcagtg  aataaagtt  ttgagcagc  780
gggaacacc  tcagcagag  tcatgaaga  acttcagcc  actgtgagg  attatgtcg  840
aaacagacc  aagtatcct  gaatcaaat  tgaagaact  tttccagat  ggatattcc  900
atcagaatc  gagcgagac  aaataaaaa  aagtcaagc  agagatctg  tatcaaaaa  960
gttagtgat  gatcctgac  agcggatct  tgtagacga  gctctgcgt  acccataca  1020
cactgtttg  tatgacccc  ccgaagcag  agccccacc  cctcaaatt  atgatgccc  1080
gttggaaga  agagaacat  caattgaag  atggaaaga  ctaatttac  aagaagtca  1140
ggattggga  gaaagaagc  agaatggtg  tgtaaaaga  cagccttca  atgcagcag  1200
aagtagcaa  gccactcct  ctcagtctt  atcgatcaa  gacatttca  ccatgtcca  1260
tgagcagac  ctggcctca  acacagaca  cagtcttga  gcctcgacg  gaccccttg  1320
aggctgtcg  tgataggtt  gaaatagca  acctgtcag  attgaagga  ctctcacct  1380
cgtgggcct  aaatgcttg  gagttgatg  aaccaaata  aaaaactcc  tgttctgca  1440
gtaagaaac  caatgcctt  ccctattca  acctgatag  attgcctgc  tagatgata  1500
aatgaggca  aatatgtct  aagaaaaaa  ttgcaagcc  cacttctag  gattttgtt  1560
aagatcatt  caggtgagc  gttagagta  gtgaatttg  ttcaaattg  actagtgac  1620
gtttctcat  atctgtaac  gttgagatg  atgtgcatg  gaccacaaa  gcttgcttg  1680
acttgccca  ctagcactt  ggaaatcag  atttaaatg  caaataatc  tccaggtag  1740
gctgcttct  aagttatct  ttaatcctc  taagtaatt  gg  1782



<210> 7238
<211> 424
<212> PRT
<213> Homo sapiens
<308> P45984
<400> 7238

Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln Val Ala 
  1               5                  10                  15
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile 
             20                  25                  30
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu 
         35                  40                  45
Gly Ile Ser Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
     50                  55                  60
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val 
 65                  70                  75                  80
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys 
                 85                  90                  95
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp 
             100                105                110
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met 
         115                120                125
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
     130                135                140
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
 145                150                155                160
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                 165                170                175
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
             180                185                190
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
         195                200                205
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile 
     210                215                220
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
 225                230                235                240
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                 245                250                255
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu 
             260                265                270
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys 
         275                280                285
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
     290                295                300
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr 
 305                310                315                320
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln 
                 325                330                335
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp 
             340                345                350
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys 
         355                360                365
Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Asn 
     370                375                380
Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser 
 385                390                395                400
Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser 
                 405                410                415
Thr Gly Pro Leu Glu Gly Cys Arg 
             420



<210> 7239
<211> 568
<212> DNA
<213> Rattus norvegicus
<308> AI231375
<400> 7239

cctggcccc  acccagacc  gcgcgggct  acactcgct  cggtatttc  aaaccgccg  60
gtcccggcc  ggcctcggg  agccccggt  catggaagt  ggctacgtg  acgacacgc  120
gttcgtgcg  tacgacagc  acgcggaga  tccgagata  gagccgcgg  cgcggtgga  180
agagcggga  gggccggag  attgggagg  gcagacaca  aacgccaag  gaaacgagc  240
gaattaccg  gtgagcctg  ggaacctgc  ccgctacta  aaccagagc  agggcggct  300
tcacaccat  cagttgatg  atggctgtg  cgtggggtc  gacgggagg  tcctccgcg  360
gtatgagca  tccgcctac  atggccgcg  ttacatcgc  ctgaacgaa  acctgaaaa  420
gtggatggc  gcggacacg  cggcacaga  gacccggaa  aagtgggag  gggctcgtt  480
tgcagagag  agcagggcc  acgtggagg  cacgtgcgt  gagtggctt  ccagatacc  540
ggagcaagg  aaggaggcg  tgctgcgc  568



<210> 7240
<211> 319
<212> PRT
<213> Rattus norvegicus
<308> P15978
<400> 7240

Met Gly Ala Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Val 
  1               5                  10                  15
Leu Ala Pro Thr Gln Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe 
             20                  25                  30
His Thr Ala Val Ser Arg Pro Gly Leu Gly Glu Pro Arg Phe Ile Ser 
         35                  40                  45
Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Tyr Asp Ser Asp Ala 
     50                  55                  60
Glu Asn Pro Arg Tyr Glu Pro Arg Ala Arg Trp Met Glu Arg Glu Gly 
 65                  70                  75                  80
Pro Glu Tyr Trp Glu Glu Gln Thr Leu Val Ala Lys Gly Gln Glu Leu 
                 85                  90                  95
Asp Tyr Arg Val Ser Leu Arg Asn Leu Leu Ser Tyr Tyr Asn Gln Ser 
             100                105                110
Glu Gly Gly Ser His Thr Ile Gln Arg Met Tyr Gly Cys Asp Val Gly 
         115                120                125
Ser Asp Gly Ser Leu Leu Arg Gly Tyr Glu Gln His Ala Tyr Asp Gly 
     130                135                140
Arg Asp Tyr Ile Ala Leu Asn Glu Asp Leu Lys Thr Trp Ala Val Ala 
 145                150                155                160
Asp Phe Ala Ala Trp Ile Thr Arg Ser Lys Trp Gln Arg Asn Gly Ala 
                 165                170                175
Ala Glu Arg Ser Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
             180                185                190
Leu Arg Tyr Leu Glu Arg Gly Lys Glu Thr Leu Leu Arg Ser Asp Pro 
         195                200                205
Pro Glu Ala His Val Thr Leu His Pro Arg Pro Glu Gly Asp Val Thr 
     210                215                220
Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr 
 225                230                235                240
Trp Gln Leu Asn Gly Glu Asp Leu Thr Gln Asp Met Glu Leu Val Glu 
                 245                250                255
Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val 
             260                265                270
Val Pro Leu Gly Lys Glu Gln Asn Tyr Thr Cys Arg Val Glu His Glu 
         275                280                285
Gly Leu Pro Glu Pro Leu Ser Gln Arg Trp Glu Pro Ser Pro Ser Thr 
     290                295                300
Asp Ser Asn Leu Leu Leu Leu Phe Leu Glu Leu Trp Gln Phe Leu 
 305                310                315



<210> 7241
<211> 528
<212> DNA
<213> Rattus norvegicus
<308> AI231445
<400> 7241

aatactagc  actttcatt  tttggaact  gtgctgaaa  aaagaagag  cagcaaata  60
tactgaaag  gcaatattc  attatcact  cgagatgag  tttgatcca  accttctcc  120
caacaatgg  cacaacggg  accccaatg  tacttctgc  gcactccgt  aaactgggg  180
tattgaaaa  ctgctgacc  cttatggat  tattcagtg  tcagaacgg  aagctaggc  240
tttcttcca  tgttcacag  ataatggca  cctccagga  ttaaaagta  gagatgatg  300
ggaatttga  gtatcatct  accggagga  tgggaaacc  attgctatt  aattggtga  360
gataaaacc  gaaatacat  ctgaagaac  aatgaatgg  caagttgtg  gcgctggtc  420
tcacaactt  gagagtgaa  ctgcagctg  cccgggtca  agtccaaca  ggagtgtat  480
ctacgaacg  aatggggaa  tattttatc  gacttacac  ctcgtgcc  528



<210> 7242
<211> 798
<212> PRT
<213> Rattus norvegicus
<308> P18395
<400> 7242

Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
  1               5                  10                  15
Pro Asn Gly Thr Ser Ala Ala Leu Arg Glu Thr Gly Val Ile Glu Lys 
             20                  25                  30
Leu Leu Thr Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg 
         35                  40                  45
Leu Phe Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys 
     50                  55                  60
Val Gly Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Thr Gly 
 65                  70                  75                  80
Lys Pro Ile Ala Ile Lys Leu Val Lys Ile Lys Pro Glu Ile His Pro 
                 85                  90                  95
Glu Glu Arg Met Asn Gly Gln Val Val Cys Ala Val Pro His Asn Leu 
             100                105                110
Glu Ser Lys Ser Pro Ala Ala Pro Gly Gln Ser Pro Thr Gly Ser Val 
         115                120                125
Cys Tyr Glu Arg Asn Gly Glu Val Phe Tyr Leu Thr Tyr Thr Ser Glu 
     130                135                140
Asp Val Glu Gly Asn Val Gln Leu Glu Thr Gly Asp Lys Ile Asn Phe 
 145                150                155                160
Val Ile Asp Asn Asn Lys His Thr Gly Ala Val Ser Ala Arg Asn Ile 
                 165                170                175
Met Leu Leu Lys Lys Lys Gln Ala Arg Tyr Gln Gly Val Val Cys Ala 
             180                185                190
Met Lys Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu 
         195                200                205
Ile Phe Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Thr Leu Gln 
     210                215                220
Pro Gly Asp Asp Val Glu Phe Thr Ile Lys Asp Arg Asn Gly Lys Glu 
 225                230                235                240
Val Ala Thr Asp Val Arg Leu Leu Pro Gln Gly Thr Val Ile Phe Glu 
                 245                250                255
Asp Ile Ser Ile Glu His Phe Glu Gly Thr Val Thr Lys Val Ile Pro 
             260                265                270
Lys Val Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile Lys 
         275                280                285
Val Asp Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp Thr 
     290                295                300
Lys Ser Lys Val Thr Leu Leu Glu Gly Asp His Val Arg Phe Asn Ile 
 305                310                315                320
Ser Thr Asp Arg Arg Asp Lys Leu Glu Arg Ala Thr Asn Ile Glu Val 
                 325                330                335
Leu Ser Asn Thr Phe Gln Phe Thr Asn Glu Ala Arg Glu Met Gly Val 
             340                345                350
Ile Ala Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp Arg 
         355                360                365
Asp Ala Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn Gln 
     370                375                380
Leu His Ile Ala Asp Glu Val Glu Phe Thr Val Val Pro Asp Met Leu 
 385                390                395                400
Ser Ala Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys Gly 
                 405                410                415
Thr Val Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Thr Val 
             420                425                430
Glu Lys Glu Ala Thr Phe Ser Asn Pro Lys Thr Thr Ser Pro Asn Lys 
         435                440                445
Gly Lys Asp Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp Cys 
     450                455                460
Gly Val Lys Leu Thr Ile Ala Phe Gln Ala Lys Asp Val Glu Gly Ser 
 465                470                475                480
Thr Ser Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp Lys 
                 485                490                495
Gln Arg Pro Gly Gln Gln Ile Ala Thr Cys Val Arg Leu Leu Gly Arg 
             500                505                510
Asn Ser Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Thr Leu Lys Asp 
         515                520                525
Asn Phe Gly Phe Ile Glu Thr Ala Asn His Asp Lys Glu Ile Phe Phe 
     530                535                540
His Tyr Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly Asp 
 545                550                555                560
Met Val Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser Ala 
                 565                570                575
Glu Lys Val Asn Lys Thr His Ser Val Asn Gly Ile Thr Glu Glu Ala 
             580                585                590
Asn Pro Thr Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Gly Val 
         595                600                605
Asp Pro Thr Gln Ile Glu Tyr Gln Gly Met Ile Glu Ile Val Glu Glu 
     610                615                620
Gly Asp Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met Ala 
 625                630                635                640
Asn Lys Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln Leu 
                 645                650                655
Cys Val Leu Gly Gln Asn Ala Gln Thr Met Ala Tyr Asn Ile Thr Pro 
             660                665                670
Leu Arg Arg Ala Thr Val Glu Cys Val Lys Asp Gln Phe Gly Phe Ile 
         675                680                685
Asn Tyr Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys Glu 
     690                695                700
Val Gln Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe Ser 
 705                710                715                720
Val Ile Leu Asn Gln Arg Thr Gly Lys Cys Ser Ala Cys Asn Val Trp 
                 725                730                735
Arg Val Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp Arg 
             740                745                750
Leu Val Asn Arg Leu Lys Asn Ile Thr Leu Asp Asp Ala Ser Ala Pro 
         755                760                765
Arg Leu Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met Gly 
     770                775                780
Phe Gly Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
 785                790                795



<210> 7243
<211> 2537
<212> DNA
<213> Homo sapiens
<308> AY049788
<400> 7243

gagtatcac  gcgagatga  ctttgatcc  aaccttctc  acaacaatg  acataatgg  60
taccctaat  gtacttcag  agcactgcg  gaaactggg  ttattgaaa  actgttaac  120
tcttacgga  ttattcagt  ttcagaacg  caagctaga  ttttcttcc  ctgttcaca  180
tataatggc  acctgcaag  cttaaaagt  ggagatgat  ttgaatttg  agtatcatc  240
gaccgacgg  ctgggaaac  cattgctgt  aaactggtg  agataaaac  agaaatcct  300
cctgaagaa  gaatgaatg  acaagaagt  ttttatctg  cttacaccc  tgaagatgt  360
gaagggaac  ttcagctgg  aactggaga  aaaataaac  ttgtaattg  taacaataa  420
catactggt  ctgtaagtg  tcgcaacat  atgctgttg  aaaagaaac  agcccgctg  480
cagggagta  tttgtgcca  gaaggaggc  tttggcttt  ttgaaagag  tgatgttgt  540
aaagagata  tctttcact  tagcgaatt  aagggtgac  tagaaacct  acagcctgg  600
gatgatgtg  aattcacaa  caaggacag  aatggtaaa  aagttgcaa  agatgtcag  660
ctattgcct  aaggaacag  catttttga  gatatcagc  ttgaacatt  tgaaggaac  720
gtaaccaaa  ttatcccaa  agtacccag  aaaaaccag  atgacccat  gccaggacg  780
atcaaagtt  actttgtga  ccctaaaga  cttcccttt  gagacaaag  tacgaaatc  840
aaggtgacc  tgctggaag  tgaccatgt  aggtttaat  tttcaacag  ccgacgtga  900
aaattagag  gagcaacca  tatagaagt  ctgtcaaat  catttcagt  cactaatga  960
gcccgagaa  tgggtgtga  tgctgccat  agagatggt  ttggtttca  caagtgtgt  1020
gatcgtgat  ttcgtatgt  cttccactt  agtgaaatt  tggatggga  ccagctcca  1080
attgcagat  aagtagagt  tactgtggt  cctgatatg  tctctgctc  aagaaatca  1140
gctattagg  ttaaaaaac  tcccaaggg  acggtttca  ttcattccc  ttcagatca  1200
cgttttctg  gcacggtag  aaaagaagc  actttttcc  atcctaaaa  cactagccc  1260
aataaaggc  aagagaagg  ggctgagga  ggcattatt  cttatgatg  ctgtggggt  1320
aaactgact  ttgcttttc  agccaagga  gtggaagga  ctacttctc  tcaaatagg  1380
gataaggtt  aatttagta  tagtgacaa  cagaggcct  gacagcagg  tgcaacttg  1440
gtgcgactt  taggtcgta  ttctaactc  aagaggctc  tgggttatg  ggcaactct  1500
aaggataat  ttggattta  tgaaacagc  aatcatgat  aggaaatct  tttccatta  1560
agtgagttc  ctggtgatg  tgatagcct  gaactgggg  acatggtcg  gtatagctt  1620
tccaaaggc  aaggcaaca  agtcagtgc  gaaaaagtg  acaaaacac  ctcagtgaa  1680
ggcattact  aggaagctg  tcccaccat  tactctggc  aagtaattc  ccccctgag  1740
agtgttgat  caacacaga  tgagtacca  ggaatgatt  agattgtgg  ggagggcga  1800
atgaaaggt  aggtctatc  atttggcat  gttgggatg  ccaacaaag  ggattgcct  1860
cagaaaggg  agagcgtca  gttccaatt  tgtgtcctg  gccaaaatg  acaaactat  1920
gcttacaac  tcacacccc  gcgcagggc  acagtggaa  gtgtgaaag  tcagtttgg  1980
ttcattaac  atgaagtag  agatagcaa  aagctcttt  tccatgtga  agaagttca  2040
gatggcatt  agctacagg  aggagatga  gtggagttc  cagtgattc  taatcagcg  2100
actggcaag  gcagcgcct  taatgtttg  cgagtctgg  gagggcccc  aggctgttg  2160
agctcctcg  cctgatcgg  tggtcaatc  cttgaagaa  atcactctg  atgatgcca  2220
tgctcctcg  ctaatggtt  ttcgtcagc  aaggggacc  gataactca  tggggtttg  2280
tgcagaaag  aagatccgt  aagctggtg  cattgacta  ccacatcca  aaagcacac  2340
attaatcca  tatgatcaa  ttgggggga  tctggtgaa  ggttctgaa  atctccctc  2400
tcatccctc  cgaaatctg  aatacttat  ctattgagc  attacacca  ttttaacac  2460
ttcctcgtg  tatgtttaa  aaaataaat  aatttaaga  aaccatttt  aataatgca  2520
agttgcagc  tggaaaa  2537



<210> 7244
<211> 798
<212> PRT
<213> Homo sapiens
<308> O75534
<400> 7244

Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
  1               5                  10                  15
Pro Asn Gly Thr Ser Ala Ala Leu Arg Glu Thr Gly Val Ile Glu Lys 
             20                  25                  30
Leu Leu Thr Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg 
         35                  40                  45
Leu Phe Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys 
     50                  55                  60
Val Gly Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Thr Gly 
 65                  70                  75                  80
Lys Pro Ile Ala Val Lys Leu Val Lys Ile Lys Gln Glu Ile Leu Pro 
                 85                  90                  95
Glu Glu Arg Met Asn Gly Gln Val Val Cys Ala Val Pro His Asn Leu 
             100                105                110
Glu Ser Lys Ser Pro Ala Ala Pro Gly Gln Ser Pro Thr Gly Ser Val 
         115                120                125
Cys Tyr Glu Arg Asn Gly Glu Val Phe Tyr Leu Thr Tyr Thr Pro Glu 
     130                135                140
Asp Val Glu Gly Asn Val Gln Leu Glu Thr Gly Asp Lys Ile Asn Phe 
 145                150                155                160
Val Ile Asp Asn Asn Lys His Thr Gly Ala Val Ser Ala Arg Asn Ile 
                 165                170                175
Met Leu Leu Lys Lys Lys Gln Ala Arg Cys Gln Gly Val Val Cys Ala 
             180                185                190
Met Lys Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu 
         195                200                205
Ile Phe Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Thr Leu Gln 
     210                215                220
Pro Gly Asp Asp Val Glu Phe Thr Ile Lys Asp Arg Asn Gly Lys Glu 
 225                230                235                240
Val Ala Thr Asp Val Arg Leu Leu Pro Gln Gly Thr Val Ile Phe Glu 
                 245                250                255
Asp Ile Ser Ile Glu His Phe Glu Gly Thr Val Thr Lys Val Ile Pro 
             260                265                270
Lys Val Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile Lys 
         275                280                285
Val Asp Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp Thr 
     290                295                300
Lys Ser Lys Val Thr Leu Leu Glu Gly Asp His Val Arg Phe Asn Ile 
 305                310                315                320
Ser Thr Asp Arg Arg Asp Lys Leu Glu Arg Ala Thr Asn Ile Glu Val 
                 325                330                335
Leu Ser Asn Thr Phe Gln Phe Thr Asn Glu Ala Arg Glu Met Gly Val 
             340                345                350
Ile Ala Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp Arg 
         355                360                365
Asp Val Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn Gln 
     370                375                380
Leu His Ile Ala Asp Glu Val Glu Phe Thr Val Val Pro Asp Met Leu 
 385                390                395                400
Ser Ala Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys Gly 
                 405                410                415
Thr Val Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Thr Val 
             420                425                430
Glu Lys Glu Ala Thr Phe Ser Asn Pro Lys Thr Thr Ser Pro Asn Lys 
         435                440                445
Gly Lys Glu Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp Cys 
     450                455                460
Gly Val Lys Leu Thr Ile Ala Phe Gln Ala Lys Asp Val Glu Gly Ser 
 465                470                475                480
Thr Ser Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp Lys 
                 485                490                495
Gln Arg Pro Gly Gln Gln Val Ala Thr Cys Val Arg Leu Leu Gly Arg 
             500                505                510
Asn Ser Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Thr Leu Lys Asp 
         515                520                525
Asn Phe Gly Phe Ile Glu Thr Ala Asn His Asp Lys Glu Ile Phe Phe 
     530                535                540
His Tyr Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly Asp 
 545                550                555                560
Met Val Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser Ala 
                 565                570                575
Glu Lys Val Asn Lys Thr His Ser Val Asn Gly Ile Thr Glu Glu Ala 
             580                585                590
Asp Pro Thr Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Ser Val 
         595                600                605
Asp Pro Thr Gln Thr Glu Tyr Gln Gly Met Ile Glu Ile Val Glu Glu 
     610                615                620
Gly Asp Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met Ala 
 625                630                635                640
Asn Lys Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln Leu 
                 645                650                655
Cys Val Leu Gly Gln Asn Ala Gln Thr Met Ala Tyr Asn Ile Thr Pro 
             660                665                670
Leu Arg Arg Ala Thr Val Glu Cys Val Lys Asp Gln Phe Gly Phe Ile 
         675                680                685
Asn Tyr Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys Glu 
     690                695                700
Val Gln Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe Ser 
 705                710                715                720
Val Ile Leu Asn Gln Arg Thr Gly Lys Cys Ser Ala Cys Asn Val Trp 
                 725                730                735
Arg Val Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp Arg 
             740                745                750
Leu Val Asn Arg Leu Lys Asn Ile Thr Leu Asp Asp Ala Ser Ala Pro 
         755                760                765
Arg Leu Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met Gly 
     770                775                780
Phe Gly Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
 785                790                795



<210> 7245
<211> 528
<212> DNA
<213> Rattus norvegicus
<308> AI231445
<400> 7245

aatactagc  actttcatt  tttggaact  gtgctgaaa  aaagaagag  cagcaaata  60
tactgaaag  gcaatattc  attatcact  cgagatgag  tttgatcca  accttctcc  120
caacaatgg  cacaacggg  accccaatg  tacttctgc  gcactccgt  aaactgggg  180
tattgaaaa  ctgctgacc  cttatggat  tattcagtg  tcagaacgg  aagctaggc  240
tttcttcca  tgttcacag  ataatggca  cctccagga  ttaaaagta  gagatgatg  300
ggaatttga  gtatcatct  accggagga  tgggaaacc  attgctatt  aattggtga  360
gataaaacc  gaaatacat  ctgaagaac  aatgaatgg  caagttgtg  gcgctggtc  420
tcacaactt  gagagtgaa  ctgcagctg  cccgggtca  agtccaaca  ggagtgtat  480
ctacgaacg  aatggggaa  tattttatc  gacttacac  ctcgtgcc  528



<210> 7246
<211> 798
<212> PRT
<213> Rattus norvegicus
<308> P18395
<400> 7246

Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
  1               5                  10                  15
Pro Asn Gly Thr Ser Ala Ala Leu Arg Glu Thr Gly Val Ile Glu Lys 
             20                  25                  30
Leu Leu Thr Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg 
         35                  40                  45
Leu Phe Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys 
     50                  55                  60
Val Gly Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Thr Gly 
 65                  70                  75                  80
Lys Pro Ile Ala Ile Lys Leu Val Lys Ile Lys Pro Glu Ile His Pro 
                 85                  90                  95
Glu Glu Arg Met Asn Gly Gln Val Val Cys Ala Val Pro His Asn Leu 
             100                105                110
Glu Ser Lys Ser Pro Ala Ala Pro Gly Gln Ser Pro Thr Gly Ser Val 
         115                120                125
Cys Tyr Glu Arg Asn Gly Glu Val Phe Tyr Leu Thr Tyr Thr Ser Glu 
     130                135                140
Asp Val Glu Gly Asn Val Gln Leu Glu Thr Gly Asp Lys Ile Asn Phe 
 145                150                155                160
Val Ile Asp Asn Asn Lys His Thr Gly Ala Val Ser Ala Arg Asn Ile 
                 165                170                175
Met Leu Leu Lys Lys Lys Gln Ala Arg Tyr Gln Gly Val Val Cys Ala 
             180                185                190
Met Lys Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu 
         195                200                205
Ile Phe Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Thr Leu Gln 
     210                215                220
Pro Gly Asp Asp Val Glu Phe Thr Ile Lys Asp Arg Asn Gly Lys Glu 
 225                230                235                240
Val Ala Thr Asp Val Arg Leu Leu Pro Gln Gly Thr Val Ile Phe Glu 
                 245                250                255
Asp Ile Ser Ile Glu His Phe Glu Gly Thr Val Thr Lys Val Ile Pro 
             260                265                270
Lys Val Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile Lys 
         275                280                285
Val Asp Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp Thr 
     290                295                300
Lys Ser Lys Val Thr Leu Leu Glu Gly Asp His Val Arg Phe Asn Ile 
 305                310                315                320
Ser Thr Asp Arg Arg Asp Lys Leu Glu Arg Ala Thr Asn Ile Glu Val 
                 325                330                335
Leu Ser Asn Thr Phe Gln Phe Thr Asn Glu Ala Arg Glu Met Gly Val 
             340                345                350
Ile Ala Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp Arg 
         355                360                365
Asp Ala Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn Gln 
     370                375                380
Leu His Ile Ala Asp Glu Val Glu Phe Thr Val Val Pro Asp Met Leu 
 385                390                395                400
Ser Ala Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys Gly 
                 405                410                415
Thr Val Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Thr Val 
             420                425                430
Glu Lys Glu Ala Thr Phe Ser Asn Pro Lys Thr Thr Ser Pro Asn Lys 
         435                440                445
Gly Lys Asp Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp Cys 
     450                455                460
Gly Val Lys Leu Thr Ile Ala Phe Gln Ala Lys Asp Val Glu Gly Ser 
 465                470                475                480
Thr Ser Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp Lys 
                 485                490                495
Gln Arg Pro Gly Gln Gln Ile Ala Thr Cys Val Arg Leu Leu Gly Arg 
             500                505                510
Asn Ser Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Thr Leu Lys Asp 
         515                520                525
Asn Phe Gly Phe Ile Glu Thr Ala Asn His Asp Lys Glu Ile Phe Phe 
     530                535                540
His Tyr Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly Asp 
 545                550                555                560
Met Val Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser Ala 
                 565                570                575
Glu Lys Val Asn Lys Thr His Ser Val Asn Gly Ile Thr Glu Glu Ala 
             580                585                590
Asn Pro Thr Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Gly Val 
         595                600                605
Asp Pro Thr Gln Ile Glu Tyr Gln Gly Met Ile Glu Ile Val Glu Glu 
     610                615                620
Gly Asp Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met Ala 
 625                630                635                640
Asn Lys Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln Leu 
                 645                650                655
Cys Val Leu Gly Gln Asn Ala Gln Thr Met Ala Tyr Asn Ile Thr Pro 
             660                665                670
Leu Arg Arg Ala Thr Val Glu Cys Val Lys Asp Gln Phe Gly Phe Ile 
         675                680                685
Asn Tyr Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys Glu 
     690                695                700
Val Gln Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe Ser 
 705                710                715                720
Val Ile Leu Asn Gln Arg Thr Gly Lys Cys Ser Ala Cys Asn Val Trp 
                 725                730                735
Arg Val Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp Arg 
             740                745                750
Leu Val Asn Arg Leu Lys Asn Ile Thr Leu Asp Asp Ala Ser Ala Pro 
         755                760                765
Arg Leu Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met Gly 
     770                775                780
Phe Gly Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
 785                790                795



<210> 7247
<211> 2537
<212> DNA
<213> Homo sapiens
<308> AY049788
<400> 7247

gagtatcac  gcgagatga  ctttgatcc  aaccttctc  acaacaatg  acataatgg  60
taccctaat  gtacttcag  agcactgcg  gaaactggg  ttattgaaa  actgttaac  120
tcttacgga  ttattcagt  ttcagaacg  caagctaga  ttttcttcc  ctgttcaca  180
tataatggc  acctgcaag  cttaaaagt  ggagatgat  ttgaatttg  agtatcatc  240
gaccgacgg  ctgggaaac  cattgctgt  aaactggtg  agataaaac  agaaatcct  300
cctgaagaa  gaatgaatg  acaagaagt  ttttatctg  cttacaccc  tgaagatgt  360
gaagggaac  ttcagctgg  aactggaga  aaaataaac  ttgtaattg  taacaataa  420
catactggt  ctgtaagtg  tcgcaacat  atgctgttg  aaaagaaac  agcccgctg  480
cagggagta  tttgtgcca  gaaggaggc  tttggcttt  ttgaaagag  tgatgttgt  540
aaagagata  tctttcact  tagcgaatt  aagggtgac  tagaaacct  acagcctgg  600
gatgatgtg  aattcacaa  caaggacag  aatggtaaa  aagttgcaa  agatgtcag  660
ctattgcct  aaggaacag  catttttga  gatatcagc  ttgaacatt  tgaaggaac  720
gtaaccaaa  ttatcccaa  agtacccag  aaaaaccag  atgacccat  gccaggacg  780
atcaaagtt  actttgtga  ccctaaaga  cttcccttt  gagacaaag  tacgaaatc  840
aaggtgacc  tgctggaag  tgaccatgt  aggtttaat  tttcaacag  ccgacgtga  900
aaattagag  gagcaacca  tatagaagt  ctgtcaaat  catttcagt  cactaatga  960
gcccgagaa  tgggtgtga  tgctgccat  agagatggt  ttggtttca  caagtgtgt  1020
gatcgtgat  ttcgtatgt  cttccactt  agtgaaatt  tggatggga  ccagctcca  1080
attgcagat  aagtagagt  tactgtggt  cctgatatg  tctctgctc  aagaaatca  1140
gctattagg  ttaaaaaac  tcccaaggg  acggtttca  ttcattccc  ttcagatca  1200
cgttttctg  gcacggtag  aaaagaagc  actttttcc  atcctaaaa  cactagccc  1260
aataaaggc  aagagaagg  ggctgagga  ggcattatt  cttatgatg  ctgtggggt  1320
aaactgact  ttgcttttc  agccaagga  gtggaagga  ctacttctc  tcaaatagg  1380
gataaggtt  aatttagta  tagtgacaa  cagaggcct  gacagcagg  tgcaacttg  1440
gtgcgactt  taggtcgta  ttctaactc  aagaggctc  tgggttatg  ggcaactct  1500
aaggataat  ttggattta  tgaaacagc  aatcatgat  aggaaatct  tttccatta  1560
agtgagttc  ctggtgatg  tgatagcct  gaactgggg  acatggtcg  gtatagctt  1620
tccaaaggc  aaggcaaca  agtcagtgc  gaaaaagtg  acaaaacac  ctcagtgaa  1680
ggcattact  aggaagctg  tcccaccat  tactctggc  aagtaattc  ccccctgag  1740
agtgttgat  caacacaga  tgagtacca  ggaatgatt  agattgtgg  ggagggcga  1800
atgaaaggt  aggtctatc  atttggcat  gttgggatg  ccaacaaag  ggattgcct  1860
cagaaaggg  agagcgtca  gttccaatt  tgtgtcctg  gccaaaatg  acaaactat  1920
gcttacaac  tcacacccc  gcgcagggc  acagtggaa  gtgtgaaag  tcagtttgg  1980
ttcattaac  atgaagtag  agatagcaa  aagctcttt  tccatgtga  agaagttca  2040
gatggcatt  agctacagg  aggagatga  gtggagttc  cagtgattc  taatcagcg  2100
actggcaag  gcagcgcct  taatgtttg  cgagtctgg  gagggcccc  aggctgttg  2160
agctcctcg  cctgatcgg  tggtcaatc  cttgaagaa  atcactctg  atgatgcca  2220
tgctcctcg  ctaatggtt  ttcgtcagc  aaggggacc  gataactca  tggggtttg  2280
tgcagaaag  aagatccgt  aagctggtg  cattgacta  ccacatcca  aaagcacac  2340
attaatcca  tatgatcaa  ttgggggga  tctggtgaa  ggttctgaa  atctccctc  2400
tcatccctc  cgaaatctg  aatacttat  ctattgagc  attacacca  ttttaacac  2460
ttcctcgtg  tatgtttaa  aaaataaat  aatttaaga  aaccatttt  aataatgca  2520
agttgcagc  tggaaaa  2537



<210> 7248
<211> 798
<212> PRT
<213> Homo sapiens
<308> O75534
<400> 7248

Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
  1               5                  10                  15
Pro Asn Gly Thr Ser Ala Ala Leu Arg Glu Thr Gly Val Ile Glu Lys 
             20                  25                  30
Leu Leu Thr Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg 
         35                  40                  45
Leu Phe Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys 
     50                  55                  60
Val Gly Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Thr Gly 
 65                  70                  75                  80
Lys Pro Ile Ala Val Lys Leu Val Lys Ile Lys Gln Glu Ile Leu Pro 
                 85                  90                  95
Glu Glu Arg Met Asn Gly Gln Val Val Cys Ala Val Pro His Asn Leu 
             100                105                110
Glu Ser Lys Ser Pro Ala Ala Pro Gly Gln Ser Pro Thr Gly Ser Val 
         115                120                125
Cys Tyr Glu Arg Asn Gly Glu Val Phe Tyr Leu Thr Tyr Thr Pro Glu 
     130                135                140
Asp Val Glu Gly Asn Val Gln Leu Glu Thr Gly Asp Lys Ile Asn Phe 
 145                150                155                160
Val Ile Asp Asn Asn Lys His Thr Gly Ala Val Ser Ala Arg Asn Ile 
                 165                170                175
Met Leu Leu Lys Lys Lys Gln Ala Arg Cys Gln Gly Val Val Cys Ala 
             180                185                190
Met Lys Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu 
         195                200                205
Ile Phe Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Thr Leu Gln 
     210                215                220
Pro Gly Asp Asp Val Glu Phe Thr Ile Lys Asp Arg Asn Gly Lys Glu 
 225                230                235                240
Val Ala Thr Asp Val Arg Leu Leu Pro Gln Gly Thr Val Ile Phe Glu 
                 245                250                255
Asp Ile Ser Ile Glu His Phe Glu Gly Thr Val Thr Lys Val Ile Pro 
             260                265                270
Lys Val Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile Lys 
         275                280                285
Val Asp Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp Thr 
     290                295                300
Lys Ser Lys Val Thr Leu Leu Glu Gly Asp His Val Arg Phe Asn Ile 
 305                310                315                320
Ser Thr Asp Arg Arg Asp Lys Leu Glu Arg Ala Thr Asn Ile Glu Val 
                 325                330                335
Leu Ser Asn Thr Phe Gln Phe Thr Asn Glu Ala Arg Glu Met Gly Val 
             340                345                350
Ile Ala Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp Arg 
         355                360                365
Asp Val Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn Gln 
     370                375                380
Leu His Ile Ala Asp Glu Val Glu Phe Thr Val Val Pro Asp Met Leu 
 385                390                395                400
Ser Ala Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys Gly 
                 405                410                415
Thr Val Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Thr Val 
             420                425                430
Glu Lys Glu Ala Thr Phe Ser Asn Pro Lys Thr Thr Ser Pro Asn Lys 
         435                440                445
Gly Lys Glu Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp Cys 
     450                455                460
Gly Val Lys Leu Thr Ile Ala Phe Gln Ala Lys Asp Val Glu Gly Ser 
 465                470                475                480
Thr Ser Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp Lys 
                 485                490                495
Gln Arg Pro Gly Gln Gln Val Ala Thr Cys Val Arg Leu Leu Gly Arg 
             500                505                510
Asn Ser Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Thr Leu Lys Asp 
         515                520                525
Asn Phe Gly Phe Ile Glu Thr Ala Asn His Asp Lys Glu Ile Phe Phe 
     530                535                540
His Tyr Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly Asp 
 545                550                555                560
Met Val Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser Ala 
                 565                570                575
Glu Lys Val Asn Lys Thr His Ser Val Asn Gly Ile Thr Glu Glu Ala 
             580                585                590
Asp Pro Thr Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Ser Val 
         595                600                605
Asp Pro Thr Gln Thr Glu Tyr Gln Gly Met Ile Glu Ile Val Glu Glu 
     610                615                620
Gly Asp Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met Ala 
 625                630                635                640
Asn Lys Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln Leu 
                 645                650                655
Cys Val Leu Gly Gln Asn Ala Gln Thr Met Ala Tyr Asn Ile Thr Pro 
             660                665                670
Leu Arg Arg Ala Thr Val Glu Cys Val Lys Asp Gln Phe Gly Phe Ile 
         675                680                685
Asn Tyr Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys Glu 
     690                695                700
Val Gln Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe Ser 
 705                710                715                720
Val Ile Leu Asn Gln Arg Thr Gly Lys Cys Ser Ala Cys Asn Val Trp 
                 725                730                735
Arg Val Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp Arg 
             740                745                750
Leu Val Asn Arg Leu Lys Asn Ile Thr Leu Asp Asp Ala Ser Ala Pro 
         755                760                765
Arg Leu Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met Gly 
     770                775                780
Phe Gly Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
 785                790                795



<210> 7249
<211> 586
<212> DNA
<213> Rattus norvegicus
<308> AI232012
<400> 7249

aatggacag  aaacgtaca  agtaactgc  aagccacat  aattaactt  ttcgttaac  60
tctgtgatc  aggaaagaa  actaggtcg  catgggtgt  ttcgttgtc  gttgtctgg  120
tgcatgacc  aggtaaccg  gtatgggcc  tggatccat  tttacacgt  ccagaagaa  180
aagcggctg  cgtgcttgg  aggcttcag  tccccttcg  tcacggggc  gggctctgg  240
cttggtctt  agtgataag  attctctgg  aaagggcga  ctgttttca  tttggtgac  300
ttagacaac  ccccaaggt  aggcctcac  cagcccagt  tgtccaaca  acattcgtc  360
aactttgcc  gctgtttgc  gcagtgacg  aacagctgc  tgctggaat  atcaaggca  420
gtccagtac  ctgtgaaag  ctccgcaca  tgactcttg  tctgccgga  gaagttcag  480
gcgcagccg  tgaccagct  gccctcctt  aggcagcgc  tagggtcct  ctcttccca  540
cggcacagc  tgaactcct  attggtctt  tcgcactga  ccccat  586



<210> 7250
<211> 172
<212> PRT
<213> Rattus norvegicus
<308> BAB22322
<400> 7250

Met Pro Gly Ile Val Glu Leu Pro Thr Leu Glu Glu Leu Lys Val Glu 
  1               5                  10                  15
Glu Val Lys Val Ser Ser Ala Val Leu Lys Ala Ala Ala His His Tyr 
             20                  25                  30
Gly Ala Gln Cys Asp Lys Thr Asn Lys Glu Phe Met Leu Cys Arg Trp 
         35                  40                  45
Glu Glu Lys Asp Pro Arg Arg Cys Leu Lys Glu Gly Lys Leu Val Asn 
     50                  55                  60
Gly Cys Ala Leu Asn Phe Phe Arg Gln Ile Lys Ser His Cys Ala Glu 
 65                  70                  75                  80
Pro Phe Thr Glu Tyr Trp Thr Cys Leu Asp Tyr Ser Asn Met Gln Leu 
                 85                  90                  95
Phe Arg His Cys Arg Gln Gln Gln Ala Lys Phe Asp Gln Cys Val Leu 
             100                105                110
Asp Lys Leu Gly Trp Val Arg Pro Asp Leu Gly Gln Leu Ser Lys Val 
         115                120                125
Thr Lys Val Lys Thr Asp Arg Pro Leu Pro Glu Asn Pro Tyr His Ser 
     130                135                140
Arg Ala Arg Pro Glu Pro Asn Pro Val Ile Glu Gly Asp Leu Lys Pro 
 145                150                155                160
Ala Lys His Gly Thr Arg Phe Phe Phe Trp Thr Val 
                 165                170



<210> 7251
<211> 772
<212> DNA
<213> Homo sapiens
<308> BC001016
<400> 7251

ggcacgagg  cgacgcggc  gagggcttc  cgtcggggt  ggggctgca  ccgtcatgc  60
ggggatagt  gagctgccc  ctctagagg  gctgaaagt  gatgaggtg  aaattagtt  120
tgctgtgct  aaagctgcg  cccatcact  tggagctca  tgtgataag  ccaacaagg  180
atttatgct  tgccgctgg  aagagaaag  tccgaggcg  tgtttagag  aaggcaaac  240
ggtcaacaa  tgtgctttg  acttcttta  gcagataaa  cgtcactgt  cagagcctt  300
tacagaata  tggacttgc  ttgattata  tggccagca  ttatttcgt  actgtcgca  360
acagcaggc  aagtttgac  agtgtgtgc  ggacaaact  ggctgggtg  ggcctgacc  420
gggagaact  tcaaaggtc  ccaaagtga  aacagatcg  cctttaccg  agaatccct  480
tcactcaag  ccaagaccg  atcccagcc  tgagatcga  ggagatctg  agcctgcca  540
acatggcag  cgcttttat  tctggacca  gtaaagatg  gtccgtggc  cacactcgg  600
catgtgctc  gacaacgac  gatgaaaac  cccatgcgg  ttgcatcga  tgatagtgt  660
ttctttccg  gatcacaaa  attaacaaa  aagttaact  atgtgactt  gcagttatt  720
tataccatt  cctgtccat  aaaattttt  aaggaaaaa  aaaaaaaaa  aa  772



<210> 7252
<211> 171
<212> PRT
<213> Homo sapiens
<308> P51970
<400> 7252

Pro Gly Ile Val Glu Leu Pro Thr Leu Glu Glu Leu Lys Val Asp Glu 
  1               5                  10                  15
Val Lys Ile Ser Ser Ala Val Leu Lys Ala Ala Ala His His Tyr Gly 
             20                  25                  30
Ala Gln Cys Asp Lys Pro Asn Lys Glu Phe Met Leu Cys Arg Trp Glu 
         35                  40                  45
Glu Lys Asp Pro Arg Arg Cys Leu Glu Glu Gly Lys Leu Val Asn Lys 
     50                  55                  60
Cys Ala Leu Asp Phe Phe Arg Gln Ile Lys Arg His Cys Ala Glu Pro 
 65                  70                  75                  80
Phe Thr Glu Tyr Trp Thr Cys Ile Asp Tyr Thr Gly Gln Gln Leu Phe 
                 85                  90                  95
Arg His Cys Arg Lys Gln Gln Ala Lys Phe Asp Glu Cys Val Leu Asp 
             100                105                110
Lys Leu Gly Trp Val Arg Pro Asp Leu Gly Glu Leu Ser Lys Val Thr 
         115                120                125
Lys Val Lys Thr Asp Arg Pro Leu Pro Glu Asn Pro Tyr His Ser Arg 
     130                135                140
Pro Arg Pro Asp Pro Ser Pro Glu Ile Glu Gly Asp Leu Gln Pro Ala 
 145                150                155                160
Thr His Gly Ser Arg Phe Tyr Phe Trp Thr Lys 
                 165                170



<210> 7253
<211> 597
<212> DNA
<213> Rattus norvegicus
<308> AI232078
<400> 7253

ggccgccaa  ctttttttt  ttttttttt  ttttttttt  ctacaaaaa  ggcgatttt  60
ttttcttat  acatacaat  gtaaatatt  tgagggggg  atttcaggt  tttaaattt  120
tctgggttg  ctttacaca  cacagtgct  ataaatgct  agaaactcc  ccatttcca  180
ccaagtaag  gatccaatt  acaggcaat  cgataatac  ttgaaaata  aggtgtttt  240
ccacccact  taaatgtag  taaaagttt  acagtcact  cctgctcca  aggacagac  300
atttgtttt  caaagtctc  ggaccaagg  acagcacaa  cctgtgtca  acttataat  360
cagtttaac  atacgttat  aaagatgtt  gcacttgag  ttatcgctg  agaaaaaat  420
gtggctggg  atctgcaca  cacagagaa  actcatata  aacatcgtc  ccactattt  480
aaagccaaa  ttaagcaat  gtaaaaaaa  aaaatcaaa  catgataat  atacaacct  540
tgtttaaaa  gacagccgc  tcctgcctc  tttccattg  attttacat  tgaacag  597



<210> 7254
<211> 1712
<212> PRT
<213> Rattus norvegicus
<308> Q00918
<400> 7254

Met Ala Gly Ala Trp Leu Arg Trp Gly Leu Leu Leu Trp Ala Gly Leu 
  1               5                  10                  15
Leu Ala Trp Ser Ala His Gly Arg Val Arg Arg Ile Thr Tyr Val Val 
             20                  25                  30
Arg Pro Gly Pro Gly Leu Pro Ala Gly Thr Leu Pro Leu Ala Gly Pro 
         35                  40                  45
Pro Arg Thr Phe Asn Val Ala Leu Asp Ala Arg Tyr Ser Arg Ser Ser 
     50                  55                  60
Thr Ala Thr Ser Ser Arg Ser Leu Ala Gly Pro Pro Ala Glu Arg Thr 
 65                  70                  75                  80
Arg Arg Thr Ser Gln Pro Gly Gly Ala Ala Leu Pro Gly Leu Arg Ser 
                 85                  90                  95
Pro Leu Pro Pro Glu Pro Ala Arg Pro Gly Ala Pro Ser Arg Gln Leu 
             100                105                110
His Ser Lys Ala Gly Ala Gln Thr Ala Val Thr Arg Phe Ala Lys His 
         115                120                125
Gly Arg Gln Val Val Arg Ser Lys Val Gln Gln Asp Thr Gln Ser Ser 
     130                135                140
Gly Gly Ser Arg Leu Gln Val Gln Gln Lys Gln Gln Leu Gln Gly Ile 
 145                150                155                160
Asn Val Cys Gly Gly Gln Cys Cys His Gly Trp Ser Lys Ala Pro Gly 
                 165                170                175
Ser Gln Arg Cys Thr Lys Pro Ser Cys Val Pro Pro Cys Gln Asn Gly 
             180                185                190
Gly Met Cys Leu Arg Pro Gln Phe Cys Val Cys Lys Pro Gly Thr Lys 
         195                200                205
Gly Lys Ala Cys Glu Ile Thr Ala Ala Gln Asp Thr Met Ser Pro Val 
     210                215                220
Phe Gly Gly Gln Asn Pro Gly Ser Ser Trp Val Pro Pro Glu Pro Ala 
 225                230                235                240
Ala Lys Arg Thr Ser Thr Lys Lys Ala Asp Thr Leu Pro Arg Val Ser 
                 245                250                255
Pro Val Ala Gln Met Thr Leu Thr Leu Lys Pro Lys Pro Ser Met Gly 
             260                265                270
Leu Ser Gln Gln Ile His Ser Gln Val Ala Pro Leu Ser Ser Gln Asn 
         275                280                285
Val Met Ile Arg His Gly Gln Thr Gln Glu Tyr Val Leu Lys Pro Lys 
     290                295                300
Tyr Phe Pro Ala Pro Lys Val Val Ser Gly Glu Gln Ser Thr Glu Gly 
 305                310                315                320
Ser Phe Ser Leu Arg Tyr Gly Gln Glu Gln Gly Thr Ala Pro Phe Gln 
                 325                330                335
Val Ser Asn His Thr Gly Arg Ile Lys Val Val Phe Thr Pro Ser Ile 
             340                345                350
Cys Lys Val Thr Cys Thr Lys Gly Asn Cys His Asn Ser Cys Gln Lys 
         355                360                365
Gly Asn Thr Thr Thr Leu Ile Ser Glu Asn Gly His Ala Ala Asp Thr 
     370                375                380
Leu Thr Ala Thr Asn Phe Arg Val Val Ile Cys His Leu Pro Cys Met 
 385                390                395                400
Asn Gly Gly Gln Cys Ser Ser Arg Asp Lys Cys Gln Cys Pro Pro Asn 
                 405                410                415
Phe Thr Gly Lys Leu Cys Gln Ile Pro Val Leu Gly Ala Ser Met Pro 
             420                425                430
Lys Leu Tyr Gln His Ala Gln Gln Pro Gly Lys Ala Leu Gly Ser His 
         435                440                445
Val Ile His Ser Thr His Thr Leu Pro Leu Thr Met Thr Asn Gln Gln 
     450                455                460
Gly Val Lys Val Lys Phe Pro Pro Asn Ile Val Asn Ile His Val Lys 
 465                470                475                480
His Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ser Arg Ile Asp 
                 485                490                495
Gly Pro Val Gly Gln Arg Val Lys Glu Val Gln Pro Gly Gln Ser Gln 
             500                505                510
Val Ser Tyr Gln Gly Leu Pro Val Gln Lys Thr Gln Thr Val His Ser 
         515                520                525
Thr Tyr Ser His Gln Gln Val Ile Pro His Val Tyr Pro Val Ala Ala 
     530                535                540
Lys Thr Gln Leu Gly Arg Cys Phe Gln Glu Thr Ile Gly Ser Gln Cys 
 545                550                555                560
Gly Lys Ala Leu Pro Gly Leu Ser Lys Gln Glu Asp Cys Cys Gly Thr 
                 565                570                575
Val Gly Thr Ser Trp Gly Phe Asn Lys Cys Gln Lys Cys Pro Lys Lys 
             580                585                590
Gln Ser Tyr His Gly Tyr Thr Gln Met Met Glu Cys Leu Gln Gly Tyr 
         595                600                605
Lys Arg Val Asn Asn Thr Phe Cys Gln Asp Ile Asn Glu Cys Gln Leu 
     610                615                620
Gln Gly Val Cys Pro Asn Gly Glu Cys Leu Asn Thr Met Gly Ser Tyr 
 625                630                635                640
Arg Cys Ser Cys Lys Met Gly Phe Gly Pro Asp Pro Thr Phe Ser Ser 
                 645                650                655
Cys Val Pro Asp Pro Pro Met Ile Ser Glu Glu Lys Gly Pro Cys Tyr 
             660                665                670
Arg Leu Val Ser Pro Gly Arg Gln Cys Met His Pro Leu Ser Val His 
         675                680                685
Leu Thr Lys Gln Ile Cys Cys Cys Ser Val Gly Lys Ala Trp Gly Pro 
     690                695                700
Gln Cys Glu Lys Cys Pro Leu Pro Gly Thr Ala Ala Phe Lys Glu Ile 
 705                710                715                720
Cys Pro Gly Gly Met Gly Tyr Thr Val Ser Gly Ile His Arg Arg Arg 
                 725                730                735
Pro Ile His Gln His Ile Gly Lys Glu Ala Val Phe Val Lys Pro Lys 
             740                745                750
Asn Thr Gln Pro Val Ala Lys Ser Thr His Pro Pro Pro Leu Pro Ala 
         755                760                765
Lys Glu Glu Pro Val Glu Ala Leu Thr Ser Ser Arg Glu His Gly Pro 
     770                775                780
Gly Val Ala Glu Pro Glu Val Val Thr Ala Pro Pro Glu Lys Glu Ile 
 785                790                795                800
Pro Ser Leu Asp Gln Glu Lys Thr Arg Leu Glu Pro Gly Gln Pro Gln 
                 805                810                815
Leu Ser Pro Gly Val Ser Thr Ile His Leu His Pro Gln Phe Pro Val 
             820                825                830
Val Val Glu Lys Thr Ser Pro Pro Val Pro Val Glu Val Ala Pro Glu 
         835                840                845
Gly Ser Thr Ser Ser Ala Ser Gln Val Ile Ala Pro Thr Gln Val Thr 
     850                855                860
Glu Ile Asn Glu Cys Thr Val Asn Pro Asp Ile Cys Gly Ala Gly His 
 865                870                875                880
Cys Ile Asn Leu Pro Val Arg Tyr Thr Cys Ile Cys Tyr Glu Gly Tyr 
                 885                890                895
Lys Phe Ser Glu Gln Gln Arg Lys Cys Ile Asp Ile Asp Glu Cys Ala 
             900                905                910
Gln Ala Gln His Leu Cys Ser Gln Gly Arg Cys Glu Asn Thr Glu Gly 
         915                920                925
Ser Phe Leu Cys Ile Cys Pro Ala Gly Phe Ile Ala Ser Glu Glu Gly 
     930                935                940
Ser Asn Cys Ile Asp Val Asp Glu Cys Leu Arg Pro Asp Val Cys Arg 
 945                950                955                960
Asp Gly Arg Cys Ile Asn Thr Ala Gly Ala Phe Arg Cys Glu Tyr Cys 
                 965                970                975
Asp Ser Gly Tyr Arg Met Ser Arg Arg Gly His Cys Glu Asp Ile Asp 
             980                985                990
Glu Cys Leu Thr Pro Ser Thr Cys Pro Glu Glu Gln Cys Val Asn Ser 
         995                1000                1005
Pro Gly Ser Tyr Gln Cys Val Pro Cys Thr Glu Gly Phe Arg Gly Trp 
     1010                1015                1020
Asn Gly Gln Cys Leu Asp Val Asp Glu Cys Leu Gln Pro Lys Val Cys 
 1025                1030                1035                1040
Thr Asn Gly Ser Cys Thr Asn Leu Glu Gly Ser Tyr Met Cys Ser Cys 
                 1045                1050                1055
His Lys Gly Tyr Ser Pro Thr Pro Asp His Arg His Cys Gln Asp Ile 
             1060                1065                1070
Asp Glu Cys Gln Gln Gly Asn Leu Cys Met Asn Gly Gln Cys Lys Asn 
         1075                1080                1085
Thr Asp Gly Ser Phe Arg Cys Thr Cys Gly Gln Gly Tyr Gln Leu Ser 
     1090                1095                1100
Ala Ala Lys Asp Gln Cys Glu Asp Ile Asp Glu Cys Glu His Arg His 
 1105                1110                1115                1120
Leu Cys Ser His Gly Gln Cys Arg Asn Thr Glu Gly Ser Phe Gln Cys 
                 1125                1130                1135
Leu Cys Asn Gln Gly Tyr Arg Ala Ser Val Leu Gly Asp His Cys Glu 
             1140                1145                1150
Asp Ile Asn Glu Cys Leu Glu Asp Ser Ser Val Cys Gln Gly Gly Asp 
         1155                1160                1165
Cys Ile Asn Thr Ala Gly Ser Tyr Asp Cys Thr Cys Pro Asp Gly Leu 
     1170                1175                1180
Gln Leu Asn Asp Asn Lys Gly Cys Gln Asp Ile Asn Glu Cys Ala Gln 
 1185                1190                1195                1200
Pro Gly Leu Cys Ala Pro His Gly Glu Cys Leu Asn Thr Gln Gly Ser 
                 1205                1210                1215
Phe His Cys Val Cys Glu Gln Gly Phe Ser Ile Ser Ala Asp Gly Arg 
             1220                1225                1230
Thr Cys Glu Asp Ile Asp Glu Cys Val Asn Asn Thr Val Cys Asp Ser 
         1235                1240                1245
His Gly Phe Cys Asp Asn Thr Ala Gly Ser Phe Arg Cys Leu Cys Tyr 
     1250                1255                1260
Gln Gly Phe Gln Ala Pro Gln Asp Gly Gln Gly Cys Val Asp Val Asn 
 1265                1270                1275                1280
Glu Cys Glu Leu Leu Ser Gly Val Cys Gly Glu Ala Phe Cys Glu Asn 
                 1285                1290                1295
Val Glu Gly Ser Phe Leu Cys Val Cys Ala Asp Glu Asn Gln Glu Tyr 
             1300                1305                1310
Ser Pro Met Thr Gly Gln Cys Arg Ser Arg Ala Thr Glu Asp Ser Gly 
         1315                1320                1325
Val Asp Arg Gln Pro Lys Glu Glu Lys Lys Glu Cys Tyr Tyr Asn Leu 
     1330                1335                1340
Asn Asp Ala Ser Leu Cys Asp Asn Val Leu Ala Pro Asn Val Thr Lys 
 1345                1350                1355                1360
Gln Glu Cys Cys Cys Thr Ser Gly Ala Gly Trp Gly Asp Asn Cys Glu 
                 1365                1370                1375
Ile Phe Pro Cys Pro Val Gln Gly Thr Ala Glu Phe Ser Glu Met Cys 
             1380                1385                1390
Pro Arg Gly Lys Gly Phe Val Pro Ala Gly Glu Ser Ser Tyr Glu Thr 
         1395                1400                1405
Gly Gly Glu Asn Tyr Lys Asp Ala Asp Glu Cys Leu Leu Phe Gly Glu 
     1410                1415                1420
Glu Ile Cys Lys Asn Gly Tyr Cys Leu Asn Thr Gln Pro Gly Tyr Glu 
 1425                1430                1435                1440
Cys Tyr Cys Lys Glu Gly Thr Tyr Tyr Asp Pro Val Lys Leu Gln Cys 
                 1445                1450                1455
Phe Asp Met Asp Glu Cys Gln Asp Pro Asn Ser Cys Ile Asp Gly Gln 
             1460                1465                1470
Cys Val Asn Thr Glu Gly Ser Tyr Asn Cys Phe Cys Thr His Pro Met 
         1475                1480                1485
Val Leu Asp Ala Ser Glu Lys Arg Cys Val Gln Pro Thr Glu Ser Asn 
     1490                1495                1500
Glu Gln Ile Glu Glu Thr Asp Val Tyr Gln Asp Leu Cys Trp Glu His 
 1505                1510                1515                1520
Leu Ser Glu Glu Tyr Val Cys Ser Arg Pro Leu Val Gly Lys Gln Thr 
                 1525                1530                1535
Thr Tyr Thr Glu Cys Cys Cys Leu Tyr Gly Glu Ala Trp Gly Met Gln 
             1540                1545                1550
Cys Ala Leu Cys Pro Met Lys Asp Ser Asp Asp Tyr Ala Gln Leu Cys 
         1555                1560                1565
Asn Ile Pro Val Thr Gly Arg Arg Arg Pro Tyr Gly Arg Asp Ala Leu 
     1570                1575                1580
Val Asp Phe Ser Glu Gln Tyr Gly Pro Glu Thr Asp Pro Tyr Phe Ile 
 1585                1590                1595                1600
Gln Asp Arg Phe Leu Asn Ser Phe Glu Glu Leu Gln Ala Glu Glu Cys 
                 1605                1610                1615
Gly Ile Leu Asn Gly Cys Glu Asn Gly Arg Cys Val Arg Val Gln Glu 
             1620                1625                1630
Gly Tyr Thr Cys Asp Cys Phe Asp Gly Tyr His Leu Asp Met Ala Lys 
         1635                1640                1645
Met Thr Cys Val Asp Val Asn Glu Cys Ser Glu Leu Asn Asn Arg Met 
     1650                1655                1660
Ser Leu Cys Lys Asn Ala Lys Cys Ile Asn Thr Glu Gly Ser Tyr Lys 
 1665                1670                1675                1680
Cys Val Cys Leu Pro Gly Tyr Val Pro Ser Asp Lys Pro Asn Tyr Cys 
                 1685                1690                1695
Thr Pro Leu Asn Thr Ala Leu Asn Leu Asp Lys Asp Ser Asp Leu Glu 
             1700                1705                1710



<210> 7255
<211> 2135
<212> DNA
<213> Homo sapiens
<308> AF039843
<400> 7255

ggcacgagg  taaggccgt  ttcttttcc  attcgctca  ctgccagga  aagggactt  60
ccgttggcg  ttcggcctc  tgttcattg  gaaaaaaga  gaaatactc  gcgtgcgct  120
gtagaaggg  agtcgtctc  agctccgaa  cccggagtg  tcatcagcg  ggaatctgg  180
tccgaattc  ctttttttc  cccgccgat  gctcggaag  tggtctaaa  cagaggttg  240
aaagaaagg  aaaaagttt  catcgagac  ggatttatt  gcacatcgc  gaaagaaga  300
aatccaagg  agaggggtt  gtgcaaagc  gcgatcacg  agttcagat  tgttctaag  360
ctgctggag  gaccacact  ccaagacct  atggaggcc  gagctcaga  tggcaacgg  420
tcgcagccc  tgctgcaga  gccccgtga  ggtggcaga  agcgtgggg  gcccgaccc  480
agagacgcc  tcacccagc  ggtacatgt  ttgtctctg  atcagatca  agccatccg  540
aacaccaat  agtacacag  ggggcctac  gtcgtccca  gacctgggc  caagcctgc  600
cctcgcccc  ccactcagc  caaacacga  agactccac  gtctgcctg  gcaccgcca  660
cctcctagg  tccagcact  gcaggtcca  tcttctgca  gagcccctc  gtccagatc  720
ataagcacg  tcagctcag  gtcgcggag  agtacgagg  caagtacca  cagcagctc  780
tctgaacag  gactgctag  atcatcctt  tcctccggg  ctgttgctg  tggcataat  840
cgggtgcaa  ccaaatctg  gctcaagcc  ggtgagctt  agccactga  caaggaaga  900
ttgggcctg  acgcctaca  gtgtgagga  tgtggcaag  gcaaatgta  ggagtgcac  960
tacccaagg  ctctgccat  agactggat  tgcgacaag  agtgccttt  ctcggccca  1020
aacgtgatt  actatggga  ttgtgtatg  tgtgtgaaa  gtctcttct  tcactgttc  1080
aatgatgat  aggacaact  tgctgacaa  ccatgttct  gcagccagt  tcactgttg  1140
acacgatgg  cagccatgg  tgtcatgtc  ctctttttg  cttgtttat  gtgttacct  1200
ccagccaag  gttgcctta  attgtgcca  gggtgttat  accgggtta  caggcctgg  1260
tgccgctgt  aaaactcaa  cacagtttg  tgcaaagtt  ccactgtcc  ccctaggaa  1320
tttgaaaaa  caacatagc  tcattaatc  ggaatatta  agtaatgag  attttttct  1380
tcttttttt  atacacata  gcaaccaac  aaacagtta  aatcttggc  ctgttaatc  1440
aaagttggg  tagtctttg  tgtttgcgg  gaaatgctt  ttgtccatg  gccgtttta  1500
ctgatatgc  tgttagaac  cagctaatg  agctcaaag  atgagatac  gaacttggt  1560
acccatgta  tgcataagc  aaagcaaca  agacactcc  aggcaaagt  tttgtttgt  1620
aatagtact  gcaaaactt  taaattagc  gatgacttt  ttccattgt  ttctccaga  1680
agaatgtgc  atatttttg  atatacaat  atatttgca  ctgtgaaaa  caagttgtg  1740
catactaca  ggcacagac  caaaatatt  tactaatat  ttgtacatt  ggaagaatg  1800
gaatcaatc  gtatgtttt  agattgtat  ttgccttac  gaaagcctt  attgtaaga  1860
tctgatttc  ctttggact  catgtatat  gtacagtta  agtaaaatt  aacctttat  1920
ttctaattt  ttcaacata  tgtttagtg  aaagaatat  tatttgaag  tttattatt  1980
tataaaaaa  aatatttat  ttaagaggc  tcttacaaa  tttgcccct  ttatgagga  2040
gtgatagtt  ctgcaaatg  ggggttaca  atgcatatg  ccaatataa  atagaaaat  2100
tattaacgt  tgaaattaa  aaaaaaaaa  aaaaa  2135



<210> 7256
<211> 315
<212> PRT
<213> Homo sapiens
<308> O43597
<400> 7256

Met Glu Ala Arg Ala Gln Ser Gly Asn Gly Ser Gln Pro Leu Leu Gln 
  1               5                  10                  15
Thr Pro Arg Asp Gly Gly Arg Gln Arg Gly Glu Pro Asp Pro Arg Asp 
             20                  25                  30
Ala Leu Thr Gln Gln Val His Val Leu Ser Leu Asp Gln Ile Arg Ala 
         35                  40                  45
Ile Arg Asn Thr Asn Glu Tyr Thr Glu Gly Pro Thr Val Val Pro Arg 
     50                  55                  60
Pro Gly Leu Lys Pro Ala Pro Arg Pro Ser Thr Gln His Lys His Glu 
 65                  70                  75                  80
Arg Leu His Gly Leu Pro Glu His Arg Gln Pro Pro Arg Leu Gln His 
                 85                  90                  95
Ser Gln Val His Ser Ser Ala Arg Ala Pro Leu Ser Arg Ser Ile Ser 
             100                105                110
Thr Val Ser Ser Gly Ser Arg Ser Ser Thr Arg Thr Ser Thr Ser Ser 
         115                120                125
Ser Ser Ser Glu Gln Arg Leu Leu Gly Ser Ser Phe Ser Ser Gly Pro 
     130                135                140
Val Ala Asp Gly Ile Ile Arg Val Gln Pro Lys Ser Glu Leu Lys Pro 
 145                150                155                160
Gly Glu Leu Lys Pro Leu Ser Lys Glu Asp Leu Gly Leu His Ala Tyr 
                 165                170                175
Arg Cys Glu Asp Cys Gly Lys Cys Lys Cys Lys Glu Cys Thr Tyr Pro 
             180                185                190
Arg Pro Leu Pro Ser Asp Trp Ile Cys Asp Lys Gln Cys Leu Cys Ser 
         195                200                205
Ala Gln Asn Val Ile Asp Tyr Gly Thr Cys Val Cys Cys Val Lys Gly 
     210                215                220
Leu Phe Tyr His Cys Ser Asn Asp Asp Glu Asp Asn Cys Ala Asp Asn 
 225                230                235                240
Pro Cys Ser Cys Ser Gln Ser His Cys Cys Thr Arg Trp Ser Ala Met 
                 245                250                255
Gly Val Met Ser Leu Phe Leu Pro Cys Leu Trp Cys Tyr Leu Pro Ala 
             260                265                270
Lys Gly Cys Leu Lys Leu Cys Gln Gly Cys Tyr Asp Arg Val Asn Arg 
         275                280                285
Pro Gly Cys Arg Cys Lys Asn Ser Asn Thr Val Cys Cys Lys Val Pro 
     290                295                300
Thr Val Pro Pro Arg Asn Phe Glu Lys Pro Thr 
 305                310                315



<210> 7257
<211> 594
<212> DNA
<213> Rattus norvegicus
<308> AI232096
<400> 7257

acctgtatg  aaaaaaatt  tattcacag  tcagtgtta  catctttta  aacaaaatt  60
atcaaagag  ttgagttaa  gcttctgga  agtgaacac  ttctaaagg  gtctggaca  120
gttctcatt  agtcatctg  ggaaagtag  tggtattgt  acctctttt  tgctttctg  180
aatctcggt  cttaaatac  gaagtattt  aagcttgac  aactggagc  gattcgctt  240
agaatatat  acattacta  taatgtgca  ttcaacatg  ccgttgaag  gaacagtgt  300
gtaaaagga  cagaaatga  aggtctttc  tataggggc  gggaacgtt  tctcctagg  360
atacatgac  cagtcctga  atcccaaac  cgtcccctg  cccacgtta  tacacgtga  420
acaatgtct  tcaactcct  ttgttcaca  gcacaaaca  aacctgcac  tgtcccacc  480
agccacaga  ttttaataa  tttctcatg  aggtccttg  ccatttgat  actagcaca  540
tttagcgct  cagacctag  atgttagta  tatcccttt  caataaccc  gaaa  594



<210> 7258
<211> 729
<212> PRT
<213> Rattus norvegicus
<308> Q63424
<400> 7258

Met Asn Pro Phe Gln Lys Asn Glu Ser Lys Glu Thr Leu Phe Ser Pro 
  1               5                  10                  15
Val Ser Thr Glu Glu Met Leu Pro Arg Pro Pro Ser Pro Pro Lys Lys 
             20                  25                  30
Ser Pro Pro Lys Ile Phe Gly Ser Ser Tyr Pro Val Ser Ile Ala Phe 
         35                  40                  45
Ile Val Val Asn Glu Phe Cys Glu Arg Phe Ser Tyr Tyr Gly Met Lys 
     50                  55                  60
Ala Val Leu Thr Leu Tyr Phe Leu Tyr Phe Leu His Trp Asn Glu Asp 
 65                  70                  75                  80
Thr Ser Thr Ser Val Tyr His Ala Phe Ser Ser Leu Cys Tyr Phe Thr 
                 85                  90                  95
Pro Ile Leu Gly Ala Ala Ile Ala Asp Ser Trp Leu Gly Lys Phe Lys 
             100                105                110
Thr Ile Ile Tyr Leu Ser Leu Val Tyr Val Leu Gly His Val Phe Lys 
         115                120                125
Ser Leu Gly Ala Ile Pro Ile Leu Gly Gly Lys Met Leu His Thr Ile 
     130                135                140
Leu Ser Leu Val Gly Leu Ser Leu Ile Ala Leu Gly Thr Gly Gly Ile 
 145                150                155                160
Lys Pro Cys Val Ala Ala Phe Gly Gly Asp Gln Phe Glu Glu Glu His 
                 165                170                175
Ala Glu Ala Arg Thr Arg Tyr Phe Ser Val Phe Tyr Leu Ala Ile Asn 
             180                185                190
Ala Gly Ser Leu Ile Ser Thr Phe Ile Thr Pro Met Leu Arg Gly Asp 
         195                200                205
Val Lys Cys Phe Gly Gln Asp Cys Tyr Ala Leu Ala Phe Gly Val Pro 
     210                215                220
Gly Leu Leu Met Val Leu Ala Leu Val Val Phe Ala Met Gly Ser Lys 
 225                230                235                240
Met Tyr Arg Lys Pro Pro Pro Glu Gly Asn Ile Val Ala Gln Val Ile 
                 245                250                255
Lys Cys Ile Trp Phe Ala Leu Cys Asn Arg Phe Arg Asn Arg Ser Gly 
             260                265                270
Asp Leu Pro Lys Arg Gln His Trp Leu Asp Trp Ala Ala Glu Lys Tyr 
         275                280                285
Pro Lys His Leu Ile Ala Asp Val Lys Ala Leu Thr Arg Val Leu Phe 
     290                295                300
Leu Tyr Ile Pro Leu Pro Met Phe Trp Ala Leu Leu Asp Gln Gln Gly 
 305                310                315                320
Ser Arg Trp Thr Leu Gln Ala Asn Lys Met Asn Gly Asp Leu Gly Phe 
                 325                330                335
Phe Val Leu Gln Pro Asp Gln Met Gln Val Leu Asn Pro Phe Leu Val 
             340                345                350
Leu Ile Phe Ile Pro Leu Phe Asp Leu Val Ile Tyr Arg Leu Ile Ser 
         355                360                365
Lys Cys Arg Ile Asn Phe Ser Ser Leu Arg Lys Met Ala Val Gly Met 
     370                375                380
Ile Leu Ala Cys Leu Ala Phe Ala Val Ala Ala Leu Val Glu Thr Lys 
 385                390                395                400
Ile Asn Gly Met Ile His Pro Gln Pro Ala Ser Gln Glu Ile Phe Leu 
                 405                410                415
Gln Val Leu Asn Leu Ala Asp Gly Asp Val Lys Val Thr Val Leu Gly 
             420                425                430
Ser Arg Asn Asn Ser Leu Leu Val Glu Ser Val Ser Ser Phe Gln Asn 
         435                440                445
Thr Thr His Tyr Ser Lys Leu His Leu Glu Ala Lys Ser Gln Asp Leu 
     450                455                460
His Phe His Leu Lys Tyr Asn Ser Leu Ser Val His Asn Asp His Ser 
 465                470                475                480
Val Glu Glu Lys Asn Cys Tyr Gln Leu Leu Ile His Gln Asp Gly Glu 
                 485                490                495
Ser Ile Ser Ser Met Leu Val Lys Asp Thr Gly Ile Lys Pro Ala Asn 
             500                505                510
Gly Met Ala Ala Ile Arg Phe Ile Asn Thr Leu His Lys Asp Leu Asn 
         515                520                525
Ile Ser Leu Asp Thr Asp Ala Pro Leu Ser Val Gly Lys Asp Tyr Gly 
     530                535                540
Val Ser Ala Tyr Arg Thr Val Leu Arg Gly Lys Tyr Pro Ala Val His 
 545                550                555                560
Cys Glu Thr Glu Asp Lys Val Phe Ser Leu Asp Leu Gly Gln Leu Asp 
                 565                570                575
Phe Gly Thr Thr Tyr Leu Phe Val Ile Thr Asn Ile Thr Ser Gln Gly 
             580                585                590
Leu Gln Ala Trp Lys Ala Glu Asp Ile Pro Val Asn Lys Leu Ser Ile 
         595                600                605
Ala Trp Gln Leu Pro Gln Tyr Val Leu Val Thr Ala Ala Glu Val Met 
     610                615                620
Phe Ser Val Thr Gly Leu Glu Phe Ser Tyr Ser Gln Ala Pro Ser Ser 
 625                630                635                640
Met Lys Ser Val Leu Gln Ala Ala Trp Leu Leu Thr Val Ala Val Gly 
                 645                650                655
Asn Ile Ile Val Leu Val Val Ala Gln Phe Ser Gly Leu Ala Gln Trp 
             660                665                670
Ala Glu Phe Val Leu Phe Ser Cys Leu Leu Leu Val Val Cys Leu Ile 
         675                680                685
Phe Ser Val Met Ala Tyr Tyr Tyr Val Pro Leu Lys Ser Glu Asp Thr 
     690                695                700
Arg Glu Ala Thr Asp Lys Gln Ile Pro Ala Val Gln Gly Asn Met Ile 
 705                710                715                720
Asn Leu Glu Thr Lys Asn Thr Arg Leu 
                 725



<210> 7259
<211> 2685
<212> DNA
<213> Homo sapiens
<308> NM_021082
<400> 7259

cgaggagag  gagagagta  ggagccagc  atgaatcct  tccagaaaa  tgagtccaa  60
gaaactctt  tttcacctg  ctccattga  gaggtacca  ctcgaccac  tagccctcc  120
aagaagcca  ctccgacaa  ctgtggctc  aactatcca  tgagcattg  cttcattgt  180
gtgaatgaa  tctgcgagc  cttttccta  tatggaatg  aagctgtgc  gatcctgta  240
ttcctgtat  tcctgcact  gaatgaaga  acctccaca  ctatatacc  tgccttcag  300
agcctctgt  attttactc  catcctggg  gcagccatt  ctgactcgt  gttgggaaa  360
ttcaagaca  tcatctatc  ctccttggt  tatgtgctt  gccatgtga  caagtcctt  420
ggtgcctta  caatactgg  aggacaagt  gtacacaca  tcctatcat  gatcggcct  480
agtctaata  ctttgggga  aggaggcat  aaaccctgt  tggcagctt  tggtggaga  540
cagtttgaa  aaaaacatg  agaggaacg  actagatac  tctcagtct  ctacctgtc  600
atcaatgca  ggagcttga  ttctacatt  atcacaccc  tgctgagag  agatgtgca  660
tgttttgga  aagactgct  tgcattggc  tttggagtt  caggactgc  catggtaat  720
gcacttgtt  tgtttgcaa  gggaagcaa  atatacaat  aaccacccc  tgaaggaaa  780
atagtggct  aagttttca  atgtatctg  tttgctatt  ccaatcgtt  caagaaccg  840
tctggagac  ttccaaagc  acacgactg  ctagactgg  cggctgaga  atatccaaa  900
cagctcatt  tggatgtaa  ggcactgac  agggtacta  tcctttata  cccattgcc  960
atgttctgg  ctcttttgg  tcagcaggg  tcacgatgg  ctttgcaag  catcaggat  1020
aataggaat  tggggtttt  tgtgcttca  ccggaccag  tgcaggttc  aaatcccct  1080
ctggttctt  tcttcatcc  gttgtttga  tttgtcatt  atcgtctgg  ctccaagtg  1140
ggaattaac  tctcatcac  taggaaaat  gctgttggt  tgatcctag  atgcctggc  1200
tttgcagtt  cggcacgtg  agagataaa  ataaatgaa  tggccccag  ccagccagg  1260
ccccaggag  ttttcctac  agtcttgaa  ctggcagat  atgaggtga  ggtgacagt  1320
gtgggaaat  aaaacaatt  tctgttgat  gagtccatc  aatcctttc  gaaaacacc  1380
cactattcc  aactgcacc  gaaaacaaa  agccaggat  ttcacttcc  cctgaaata  1440
cacaatttg  ctctctaca  tgagcattc  gtgcaggag  agaactggt  cagtcttgt  1500
attcgtgaa  atgggaaca  tatctccag  atgatggta  aggatacag  aagcagaac  1560
accaatggg  tgacaaccg  gaggtttgt  aacactttg  ataaagatg  caacatctc  1620
ctgagtaca  atacctctc  caatgttgg  gaagactat  gtgtgtctg  ttatagaac  1680
gtgcaaaga  gagaatacc  tgcagtgca  tgtagaaca  aagataaga  cttttctct  1740
aatttgggt  ttctagact  tggtgcagc  tatctgttt  ttattacta  taacaccaa  1800
cagggtctt  aggcctgga  gattgaaga  attccagcc  acaaaatgt  cattcggtg  1860
cagctacca  aatatgccc  ggttacagc  ggggaggtc  tgttctctg  cacaggtct  1920
gagttttct  attctcagg  tccctctag  atgaaatct  tgctccagg  agcttggct  1980
ttgacaatt  cagttggga  tatcatcgt  cttgttgtg  cacagttca  tggcctggt  2040
cagtgggcc  aattcattt  gttttcctg  ctcctgctg  tgatctgcc  gatcttctc  2100
atcatgggc  actactatg  tcctgtaaa  acagaggat  tgcggggtc  agcagataa  2160
cacattcct  acatccagg  gaacatgat  aaactagag  ccaagaaga  aaaactctg  2220
tgactccct  gattctgtc  taaccccaa  tccctggcc  tgtcttgaa  cattttttt  2280
cttctactg  attagacaa  agagatagc  gcatatcag  gctgatctc  tccaccttt  2340
tccaatgac  gaagttcca  gactggttt  ccagtacat  tttaaacaa  gccccagag  2400
ctctatgtc  gcccgtcca  cagtgaact  attaaaact  gtgcagtgt  gctggagct  2460
gcctggtgt  tccaaatga  catgaaaat  cacacgtat  atggagatc  ttctctgtg  2520
gtatgcaaa  ttatgggaa  tcctttata  gtaactgcc  tttaggact  atggcccta  2580
tttttgagg  gctgattta  aggcaaaat  gcagaataa  aaagaaatg  tatttcaag  2640
ttttttttt  ataagcaat  taattatgc  attcacagg  gcccg  2685



<210> 7260
<211> 729
<212> PRT
<213> Homo sapiens
<308> Q16348
<400> 7260

Met Asn Pro Phe Gln Lys Asn Glu Ser Lys Glu Thr Leu Phe Ser Pro 
  1               5                  10                  15
Val Ser Ile Glu Glu Val Pro Pro Arg Pro Pro Ser Pro Pro Lys Lys 
             20                  25                  30
Pro Ser Pro Thr Ile Cys Gly Ser Asn Tyr Pro Leu Ser Ile Ala Phe 
         35                  40                  45
Ile Val Val Asn Glu Phe Cys Glu Arg Phe Ser Tyr Tyr Gly Met Lys 
     50                  55                  60
Ala Val Leu Ile Leu Tyr Phe Leu Tyr Phe Leu His Trp Asn Glu Asp 
 65                  70                  75                  80
Thr Ser Thr Ser Ile Tyr His Ala Phe Ser Ser Leu Cys Tyr Phe Thr 
                 85                  90                  95
Pro Ile Leu Gly Ala Ala Ile Ala Asp Ser Trp Leu Gly Lys Phe Lys 
             100                105                110
Thr Ile Ile Tyr Leu Ser Leu Val Tyr Val Leu Gly His Val Ile Lys 
         115                120                125
Ser Leu Gly Ala Leu Pro Ile Leu Gly Gly Gln Val Val His Thr Val 
     130                135                140
Leu Ser Leu Ile Gly Leu Ser Leu Ile Ala Leu Gly Thr Gly Gly Ile 
 145                150                155                160
Lys Pro Cys Val Ala Ala Phe Gly Gly Asp Gln Phe Glu Glu Lys His 
                 165                170                175
Ala Glu Glu Arg Thr Arg Tyr Phe Ser Val Phe Tyr Leu Ser Ile Asn 
             180                185                190
Ala Gly Ser Leu Ile Ser Thr Phe Ile Thr Pro Met Leu Arg Gly Asp 
         195                200                205
Val Gln Cys Phe Gly Glu Asp Cys Tyr Ala Leu Ala Phe Gly Val Pro 
     210                215                220
Gly Leu Leu Met Val Ile Ala Leu Val Val Phe Ala Met Gly Ser Lys 
 225                230                235                240
Ile Tyr Asn Lys Pro Pro Pro Glu Gly Asn Ile Val Ala Gln Val Phe 
                 245                250                255
Lys Cys Ile Trp Phe Ala Ile Ser Asn Arg Phe Lys Asn Arg Ser Gly 
             260                265                270
Asp Ile Pro Lys Arg His Asp Trp Leu Asp Trp Ala Ala Glu Lys Tyr 
         275                280                285
Pro Lys Gln Leu Ile Met Asp Val Lys Ala Leu Thr Arg Val Leu Phe 
     290                295                300
Leu Tyr Ile Pro Leu Pro Met Phe Trp Ala Leu Leu Asp Gln Gln Gly 
 305                310                315                320
Ser Arg Trp Thr Leu Gln Ala Ile Arg Met Asn Arg Asn Leu Gly Phe 
                 325                330                335
Phe Val Leu Gln Pro Asp Gln Met Gln Val Leu Asn Pro Leu Leu Val 
             340                345                350
Leu Ile Phe Ile Pro Leu Phe Asp Phe Val Ile Tyr Arg Leu Val Ser 
         355                360                365
Lys Cys Gly Ile Asn Phe Ser Ser Leu Arg Lys Met Ala Val Gly Met 
     370                375                380
Ile Leu Ala Cys Leu Ala Phe Ala Val Ala Ala Arg Val Glu Ile Lys 
 385                390                395                400
Ile Asn Glu Met Ala Pro Ala Gln Pro Gly Pro Gln Glu Val Phe Leu 
                 405                410                415
Gln Val Leu Asn Leu Ala Asp Asp Glu Val Lys Val Thr Val Val Gly 
             420                425                430
Asn Glu Asn Asn Ser Leu Leu Ile Glu Ser Ile Lys Ser Phe Gln Lys 
         435                440                445
Thr Pro His Tyr Ser Lys Leu His Leu Lys Thr Lys Ser Gln Asp Phe 
     450                455                460
His Phe His Leu Lys Tyr His Asn Leu Ser Leu Tyr Thr Glu His Ser 
 465                470                475                480
Val Gln Glu Lys Asn Trp Tyr Ser Leu Val Ile Arg Glu Asp Gly Asn 
                 485                490                495
Ser Ile Ser Ser Met Met Val Lys Asp Thr Glu Ser Arg Thr Thr Asn 
             500                505                510
Gly Met Thr Thr Val Arg Phe Val Asn Thr Leu His Lys Asp Val Asn 
         515                520                525
Ile Ser Leu Ser Thr Asp Thr Ser Leu Asn Val Gly Glu Asp Tyr Gly 
     530                535                540
Val Ser Ala Tyr Arg Thr Val Gln Arg Gly Glu Tyr Pro Ala Val His 
 545                550                555                560
Cys Arg Thr Glu Asp Lys Asn Phe Ser Leu Asn Leu Gly Leu Leu Asp 
                 565                570                575
Phe Gly Ala Ala Tyr Leu Phe Val Ile Thr Asn Asn Thr Asn Gln Gly 
             580                585                590
Leu Gln Ala Trp Lys Ile Glu Asp Ile Pro Ala Asn Lys Met Ser Ile 
         595                600                605
Arg Trp Gln Leu Pro Gln Tyr Ala Leu Val Thr Ala Gly Glu Val Met 
     610                615                620
Phe Ser Val Thr Gly Leu Glu Phe Ser Tyr Ser Gln Ala Pro Ser Ser 
 625                630                635                640
Met Lys Ser Val Leu Gln Ala Ala Trp Leu Leu Thr Ile Ala Val Gly 
                 645                650                655
Asn Ile Ile Val Leu Val Val Ala Gln Phe Ser Gly Leu Val Gln Trp 
             660                665                670
Ala Glu Phe Ile Leu Phe Ser Cys Leu Leu Leu Val Ile Cys Leu Ile 
         675                680                685
Phe Ser Ile Met Gly Tyr Tyr Tyr Val Pro Val Lys Thr Glu Asp Met 
     690                695                700
Arg Gly Pro Ala Asp Lys His Ile Pro His Ile Gln Gly Asn Met Ile 
 705                710                715                720
Lys Leu Glu Thr Lys Lys Thr Lys Leu 
                 725



<210> 7261
<211> 590
<212> DNA
<213> Rattus norvegicus
<308> AI232321
<400> 7261

agatttggc  tttgtttta  tttgttttg  tatgtttga  gtaaggtct  tatagtcct  60
gctggcctc  aactcggag  tcttcctat  tctgcattc  aagttctag  attagagga  120
tgtgccccc  tgcatagct  atttggctt  attttgata  ttatttcaa  attatctac  180
tgattaaca  gtaatcaaa  tttcctcca  acccaacca  gagtaatgt  ccattcagt  240
gtttcagtc  ggacaaaaa  tttgttacc  aattcaatt  aattacaca  agtagaaat  300
tgcctctcc  aagagtgat  aaaatattt  ttttttaaa  caaaacaga  ccttgaaga  360
tgaaactac  acacagacc  cctatgcaa  acacaacca  gtcggggga  catttatca  420
agcagataa  tgccatcct  ataacagac  agaccggag  tgtaagtgc  atttgtcat  480
aacccgtct  ccattaacc  gaagccttt  gtttatttc  tgtagcaaa  cactcgtca  540
ttttgtctg  tgccattgc  tcatccaac  atttgcttc  ttttggatcc  590



<210> 7262
<211> 609
<212> DNA
<213> Rattus norvegicus
<308> AI232374
<400> 7262

cctttccag  tttatttta  agttttaaa  ttacaacca  agtaatttt  tcccggcac  60
agttacact  gtttaaaaa  tggggtagg  tacccgagt  tcctacttt  ttaaaataa  120
aggacaact  tacagagtt  ttctcccag  tcccgaggt  agactaagt  ctagtctta  180
atatggata  atacatata  acacatgca  acaatcccg  ttctctaaa  ctacctagc  240
aattcgaat  cacgggagt  tatcccaca  tccactccc  gcctctccc  ctcctcggc  300
acttagaaa  gactcaaaa  cttggaggg  ttttaagtg  cagctggta  aactgaagt  360
gcaccaagc  atgccacat  ttacacagg  agaggggaa  ggaaacgaa  aacgtcctc  420
taggacaca  tccatcaac  gtgtggaaa  acccaagtt  ccataggca  actgaggca  480
ttggctgac  ctgcacccc  ccccctaag  ccactccca  ttaaccaga  actgctgag  540
agacccttc  ttcccaatg  ctaaatccc  gttgtgaga  gctatggct  ctctaacca  600
ctgtcactt  609



<210> 7263
<211> 193
<212> PRT
<213> Rattus norvegicus
<308> P43278
<400> 7263

Thr Glu Asn Ser Thr Ser Thr Pro Ala Ala Lys Pro Lys Arg Ala Lys 
  1               5                  10                  15
Ala Ala Lys Lys Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile Val 
             20                  25                  30
Ala Ala Ile Gln Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln Ser 
         35                  40                  45
Ile Gln Lys Tyr Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala Asp 
     50                  55                  60
Ser Gln Ile Lys Leu Ser Ile Lys Arg Leu Val Thr Thr Gly Val Leu 
 65                  70                  75                  80
Lys Gln Thr Lys Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala Lys 
                 85                  90                  95
Gly Asp Glu Pro Lys Arg Ser Val Ala Phe Lys Lys Thr Lys Lys Glu 
             100                105                110
Val Lys Lys Val Ala Thr Pro Lys Lys Ala Ala Lys Pro Lys Lys Ala 
         115                120                125
Ala Ser Lys Ala Pro Ser Lys Lys Pro Lys Ala Thr Pro Val Lys Lys 
     130                135                140
Ala Lys Lys Lys Pro Ala Ala Thr Pro Lys Lys Ala Lys Lys Pro Lys 
 145                150                155                160
Ile Val Lys Val Lys Pro Val Lys Ala Ser Lys Pro Lys Lys Ala Lys 
                 165                170                175
Pro Val Lys Pro Lys Ala Lys Ser Ser Ala Lys Arg Ala Ser Lys Lys 
             180                185                190
Lys 
         195



<210> 7264
<211> 2258
<212> DNA
<213> Homo sapiens
<308> NM_005318
<400> 7264

gccctgtcc  caccgcggt  cgcccgccg  cgctaaata  ccggatgcg  cgcccaagc  60
ccagacgcg  agctgggaa  agggaggca  aggaggcag  ggcagaggc  gaggcagag  120
ccggtgccg  gaccaagcg  cagaccggc  gggctgggc  tcgcaaagc  ggctcggcg  180
gctctcccg  cacccgagc  ggggaggaa  agcagcgac  cctcgctcg  atccccggg  240
gccgcactc  agactggcc  ggtagtcag  ggctcagga  cagatcccg  ggcaggctt  300
gctcagcct  cgacgaggg  tggcccttt  gaaggcgcc  tcaacagcc  gaccagaca  360
gccaccatg  ccgagaatt  cacgtccgc  cctgcggcc  agcccaagc  ggccaaggc  420
tccaagaag  ccacagacc  ccccaagta  tcagacatg  tcgtggctg  catccaggc  480
gagaagaac  gcgctggct  ctcgcgcca  tccattcag  agtatatca  gagccacta  540
aaggtgggt  agaacgctg  ctcgcagat  aagttgtcc  tcaagcgcc  ggtcaccac  600
ggtgtcctc  agcagacca  aggggtggg  gcctcgggg  ccttccggc  agccaagag  660
gacgaaccc  agaagtcag  ggccttcaa  aagaccaag  aggaaatca  gaaggtagc  720
acgccaaag  aggcatcca  gcccaagaa  gctgcctcc  aagccccaa  caagaaacc  780
aaagccacc  cggtcaaga  ggccaagaa  aagctggct  ccacgccca  gaaagccaa  840
aaacccaag  ctgtcaaag  caagccggt  aaggcatcc  agcccaaaa  ggccaaacc  900
gtgaaaccc  aagcaaagt  cagtgccaa  agggccggc  agaagaagt  acaatgaag  960
cttttcttg  ggacactcc  tcctgtctc  tattttctg  aaataattt  ctccttttt  1020
ctctcttga  gctcaccac  accttttgc  cccttctgt  ctgacttta  aagagacag  1080
atttggatt  ttcagaaat  acagaataa  tcatttttc  ttaaccagt  gtgcaagga  1140
agcaacaac  aatctaatg  tgagaatgt  cttatattt  gttttgcta  taacctact  1200
acggggtta  ggatttgcg  ggggggctt  tgtgttttg  tggcttgtt  gccatgaag  1260
tagatgtgg  tggggagaa  acacaaggc  gtttgttct  gctagatga  agggaaccc  1320
ggaattgtg  ggttagcag  aatatcttt  gggtgagtg  gttttcctt  agttgggca  1380
ccgttgtga  agtttcaga  cctttggcc  gcaggagag  ggtggtagg  agcagccag  1440
cggcaaagg  aggaggtgg  aaaaaaccg  caccgggct  acttccacc  cccagtggt  1500
agcagtggg  gcccaaacc  agtttcctt  tcatttttg  tagtttgcc  tttcggcct  1560
cctattttc  tagggaagg  gagtggggt  caagtgaca  ctggatggg  gaagccata  1620
tttctccca  tcagctagg  tgtagccat  gggggatct  tgtggcttc  gcaaattct  1680
ttgttaaac  ggagtgaaa  cttcagggg  agggtgggg  gtcagccaa  tgcctcagt  1740
tgccctgtt  aaacttagg  ttttccacg  aatcgatgg  ttgtgtcct  ggaagactt  1800
tcttttcct  tggattttt  ttcctcctg  acaagaggt  tctttgctt  gtttggtgg  1860
gctgcggcc  cttaaaacc  cccgatctc  ttttgagtc  tttattata  gtagttgta  1920
ctgcgggag  gggaggggg  gtgggcggg  agtggatag  aagacttac  gcagtcgat  1980
tgggatttg  taagtagtt  tacagagct  gatctgtgt  catgtgtgt  tttgtgtat  2040
tatacatat  tagggctag  acttagttt  acacccggg  gctgggaga  aaaacctgt  2100
cagttgtct  tctcttatt  ttaataaaa  agaaaaatc  cgcacttgc  cgtcccccc  2160
ccaccccct  ttttaaaca  gtgttactt  tgccgggaa  attttgctg  ctttgtaat  2220
ttaaaactt  aaaataaat  ggaaaaggg  gaaactga  2258



<210> 7265
<211> 193
<212> PRT
<213> Homo sapiens
<308> P07305
<400> 7265

Thr Glu Asn Ser Thr Ser Ala Pro Ala Ala Lys Pro Lys Arg Ala Lys 
  1               5                  10                  15
Ala Ser Lys Lys Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile Val 
             20                  25                  30
Ala Ala Ile Gln Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln Ser 
         35                  40                  45
Ile Gln Lys Tyr Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala Asp 
     50                  55                  60
Ser Gln Ile Lys Leu Ser Ile Lys Arg Leu Val Thr Thr Gly Val Leu 
 65                  70                  75                  80
Lys Gln Thr Lys Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala Lys 
                 85                  90                  95
Ser Asp Glu Pro Lys Lys Ser Val Ala Phe Lys Lys Thr Lys Lys Glu 
             100                105                110
Ile Lys Lys Val Ala Thr Pro Lys Lys Ala Ser Lys Pro Lys Lys Ala 
         115                120                125
Ala Ser Lys Ala Pro Thr Lys Lys Pro Lys Ala Thr Pro Val Lys Lys 
     130                135                140
Ala Lys Lys Lys Leu Ala Ala Thr Pro Lys Lys Ala Lys Lys Pro Lys 
 145                150                155                160
Thr Val Lys Ala Lys Pro Val Lys Ala Ser Lys Pro Lys Lys Ala Lys 
                 165                170                175
Pro Val Lys Pro Lys Ala Lys Ser Ser Ala Lys Arg Ala Gly Lys Lys 
             180                185                190
Lys 
         195



<210> 7266
<211> 609
<212> DNA
<213> Rattus norvegicus
<308> AI232374
<400> 7266

cctttccag  tttatttta  agttttaaa  ttacaacca  agtaatttt  tcccggcac  60
agttacact  gtttaaaaa  tggggtagg  tacccgagt  tcctacttt  ttaaaataa  120
aggacaact  tacagagtt  ttctcccag  tcccgaggt  agactaagt  ctagtctta  180
atatggata  atacatata  acacatgca  acaatcccg  ttctctaaa  ctacctagc  240
aattcgaat  cacgggagt  tatcccaca  tccactccc  gcctctccc  ctcctcggc  300
acttagaaa  gactcaaaa  cttggaggg  ttttaagtg  cagctggta  aactgaagt  360
gcaccaagc  atgccacat  ttacacagg  agaggggaa  ggaaacgaa  aacgtcctc  420
taggacaca  tccatcaac  gtgtggaaa  acccaagtt  ccataggca  actgaggca  480
ttggctgac  ctgcacccc  ccccctaag  ccactccca  ttaaccaga  actgctgag  540
agacccttc  ttcccaatg  ctaaatccc  gttgtgaga  gctatggct  ctctaacca  600
ctgtcactt  609



<210> 7267
<211> 193
<212> PRT
<213> Rattus norvegicus
<308> P43278
<400> 7267

Thr Glu Asn Ser Thr Ser Thr Pro Ala Ala Lys Pro Lys Arg Ala Lys 
  1               5                  10                  15
Ala Ala Lys Lys Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile Val 
             20                  25                  30
Ala Ala Ile Gln Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln Ser 
         35                  40                  45
Ile Gln Lys Tyr Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala Asp 
     50                  55                  60
Ser Gln Ile Lys Leu Ser Ile Lys Arg Leu Val Thr Thr Gly Val Leu 
 65                  70                  75                  80
Lys Gln Thr Lys Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala Lys 
                 85                  90                  95
Gly Asp Glu Pro Lys Arg Ser Val Ala Phe Lys Lys Thr Lys Lys Glu 
             100                105                110
Val Lys Lys Val Ala Thr Pro Lys Lys Ala Ala Lys Pro Lys Lys Ala 
         115                120                125
Ala Ser Lys Ala Pro Ser Lys Lys Pro Lys Ala Thr Pro Val Lys Lys 
     130                135                140
Ala Lys Lys Lys Pro Ala Ala Thr Pro Lys Lys Ala Lys Lys Pro Lys 
 145                150                155                160
Ile Val Lys Val Lys Pro Val Lys Ala Ser Lys Pro Lys Lys Ala Lys 
                 165                170                175
Pro Val Lys Pro Lys Ala Lys Ser Ser Ala Lys Arg Ala Ser Lys Lys 
             180                185                190
Lys 
         195



<210> 7268
<211> 2258
<212> DNA
<213> Homo sapiens
<308> NM_005318
<400> 7268

gccctgtcc  caccgcggt  cgcccgccg  cgctaaata  ccggatgcg  cgcccaagc  60
ccagacgcg  agctgggaa  agggaggca  aggaggcag  ggcagaggc  gaggcagag  120
ccggtgccg  gaccaagcg  cagaccggc  gggctgggc  tcgcaaagc  ggctcggcg  180
gctctcccg  cacccgagc  ggggaggaa  agcagcgac  cctcgctcg  atccccggg  240
gccgcactc  agactggcc  ggtagtcag  ggctcagga  cagatcccg  ggcaggctt  300
gctcagcct  cgacgaggg  tggcccttt  gaaggcgcc  tcaacagcc  gaccagaca  360
gccaccatg  ccgagaatt  cacgtccgc  cctgcggcc  agcccaagc  ggccaaggc  420
tccaagaag  ccacagacc  ccccaagta  tcagacatg  tcgtggctg  catccaggc  480
gagaagaac  gcgctggct  ctcgcgcca  tccattcag  agtatatca  gagccacta  540
aaggtgggt  agaacgctg  ctcgcagat  aagttgtcc  tcaagcgcc  ggtcaccac  600
ggtgtcctc  agcagacca  aggggtggg  gcctcgggg  ccttccggc  agccaagag  660
gacgaaccc  agaagtcag  ggccttcaa  aagaccaag  aggaaatca  gaaggtagc  720
acgccaaag  aggcatcca  gcccaagaa  gctgcctcc  aagccccaa  caagaaacc  780
aaagccacc  cggtcaaga  ggccaagaa  aagctggct  ccacgccca  gaaagccaa  840
aaacccaag  ctgtcaaag  caagccggt  aaggcatcc  agcccaaaa  ggccaaacc  900
gtgaaaccc  aagcaaagt  cagtgccaa  agggccggc  agaagaagt  acaatgaag  960
cttttcttg  ggacactcc  tcctgtctc  tattttctg  aaataattt  ctccttttt  1020
ctctcttga  gctcaccac  accttttgc  cccttctgt  ctgacttta  aagagacag  1080
atttggatt  ttcagaaat  acagaataa  tcatttttc  ttaaccagt  gtgcaagga  1140
agcaacaac  aatctaatg  tgagaatgt  cttatattt  gttttgcta  taacctact  1200
acggggtta  ggatttgcg  ggggggctt  tgtgttttg  tggcttgtt  gccatgaag  1260
tagatgtgg  tggggagaa  acacaaggc  gtttgttct  gctagatga  agggaaccc  1320
ggaattgtg  ggttagcag  aatatcttt  gggtgagtg  gttttcctt  agttgggca  1380
ccgttgtga  agtttcaga  cctttggcc  gcaggagag  ggtggtagg  agcagccag  1440
cggcaaagg  aggaggtgg  aaaaaaccg  caccgggct  acttccacc  cccagtggt  1500
agcagtggg  gcccaaacc  agtttcctt  tcatttttg  tagtttgcc  tttcggcct  1560
cctattttc  tagggaagg  gagtggggt  caagtgaca  ctggatggg  gaagccata  1620
tttctccca  tcagctagg  tgtagccat  gggggatct  tgtggcttc  gcaaattct  1680
ttgttaaac  ggagtgaaa  cttcagggg  agggtgggg  gtcagccaa  tgcctcagt  1740
tgccctgtt  aaacttagg  ttttccacg  aatcgatgg  ttgtgtcct  ggaagactt  1800
tcttttcct  tggattttt  ttcctcctg  acaagaggt  tctttgctt  gtttggtgg  1860
gctgcggcc  cttaaaacc  cccgatctc  ttttgagtc  tttattata  gtagttgta  1920
ctgcgggag  gggaggggg  gtgggcggg  agtggatag  aagacttac  gcagtcgat  1980
tgggatttg  taagtagtt  tacagagct  gatctgtgt  catgtgtgt  tttgtgtat  2040
tatacatat  tagggctag  acttagttt  acacccggg  gctgggaga  aaaacctgt  2100
cagttgtct  tctcttatt  ttaataaaa  agaaaaatc  cgcacttgc  cgtcccccc  2160
ccaccccct  ttttaaaca  gtgttactt  tgccgggaa  attttgctg  ctttgtaat  2220
ttaaaactt  aaaataaat  ggaaaaggg  gaaactga  2258



<210> 7269
<211> 193
<212> PRT
<213> Homo sapiens
<308> P07305
<400> 7269

Thr Glu Asn Ser Thr Ser Ala Pro Ala Ala Lys Pro Lys Arg Ala Lys 
  1               5                  10                  15
Ala Ser Lys Lys Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile Val 
             20                  25                  30
Ala Ala Ile Gln Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln Ser 
         35                  40                  45
Ile Gln Lys Tyr Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala Asp 
     50                  55                  60
Ser Gln Ile Lys Leu Ser Ile Lys Arg Leu Val Thr Thr Gly Val Leu 
 65                  70                  75                  80
Lys Gln Thr Lys Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala Lys 
                 85                  90                  95
Ser Asp Glu Pro Lys Lys Ser Val Ala Phe Lys Lys Thr Lys Lys Glu 
             100                105                110
Ile Lys Lys Val Ala Thr Pro Lys Lys Ala Ser Lys Pro Lys Lys Ala 
         115                120                125
Ala Ser Lys Ala Pro Thr Lys Lys Pro Lys Ala Thr Pro Val Lys Lys 
     130                135                140
Ala Lys Lys Lys Leu Ala Ala Thr Pro Lys Lys Ala Lys Lys Pro Lys 
 145                150                155                160
Thr Val Lys Ala Lys Pro Val Lys Ala Ser Lys Pro Lys Lys Ala Lys 
                 165                170                175
Pro Val Lys Pro Lys Ala Lys Ser Ser Ala Lys Arg Ala Gly Lys Lys 
             180                185                190
Lys 
         195



<210> 7270
<211> 629
<212> DNA
<213> Rattus norvegicus
<308> AI233261
<400> 7270

catggatca  agaatcaat  ttatttaca  tactagtag  ctgctatag  tactctgag  60
tagattatt  tgtcaacga  aggaaaaaa  tctcttcca  tatgtctta  caactgtaa  120
gtaattgct  agttataga  gtatagagt  agaagcagc  actgaattt  agaaataaa  180
aatatgtat  tacatcacc  tgatgccta  gccaaaata  atcttaaaa  aaattttct  240
gatttctat  actcataaa  ataaaggaa  tatattgca  gtatttttc  ttatagacg  300
tttcagtta  aaaccaaga  tttaatgaa  agaatacaa  gcttcctgt  agtgcgctg  360
tgcagacgc  agggaggta  tcaaactca  cacattgcc  aaccaccac  ttcacgcct  420
agtgacgct  tttgtaggc  agagctaga  tttttttta  acatctcaa  tttatcatg  480
attttaatc  tatgttcca  ataaataca  ggcccctga  ttgtgagct  gagctgtag  540
taagaaccc  ttcttttgg  ttgcaaaat  tatcctttt  acttgatga  tcctctgct  600
ttcacgatg  ccgagtacc  naacagcca  629



<210> 7271
<211> 274
<212> PRT
<213> Rattus norvegicus
<308> P48508
<400> 7271

Met Gly Thr Asp Ser Arg Ala Ala Gly Ala Leu Leu Ala Arg Ala Ser 
  1               5                  10                  15
Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 
             20                  25                  30
Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu Arg Asp Cys Ile Gln 
         35                  40                  45
Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Ser Pro Asp Leu Val Arg 
     50                  55                  60
Glu Phe Pro Asp Val Leu Glu Cys Thr Met Ser His Ala Val Glu Lys 
 65                  70                  75                  80
Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 
                 85                  90                  95
Ile Val Gly Ser Asn Ser Ser Ser Ser Thr Arg Asn Ala Val Asp Met 
             100                105                110
Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Met Ala 
         115                120                125
Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 
     130                135                140
Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 
 145                150                155                160
Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 
                 165                170                175
Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 
             180                185                190
Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 
         195                200                205
Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 
     210                215                220
Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Glu Ala Gln 
 225                230                235                240
Glu Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 
                 245                250                255
Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Lys 
             260                265                270
Gly Ser 
         275



<210> 7272
<211> 1610
<212> DNA
<213> Homo sapiens
<308> L35546
<400> 7272

ggcacgagg  tgcggccgc  gtagccgga  ccggagccg  agccaccgg  gccttcctt  60
cccgccgcc  cccagccgc  gtccggcct  cctcgggcc  gagcgcaga  caggctcca  120
ccgcgcggc  ccggcagcc  cgcgctccc  ctcgggtct  tctcgggcc  cgggcaccg  180
gtcctgtgg  cggccgcct  cctgcccgc  cgcccgcag  cccttgcct  ccggcccct  240
ggcggcccg  gccatgggc  ccgacagcc  cgcggccaa  gcgctcctg  cgcgggccc  300
caccctgca  ctgcagacg  ggaacctgc  gaactgggg  cgcctgcgg  agaagtgcc  360
gtccacgca  agcgaggag  ttcatgatt  tatccaaaa  accttgaat  aatggagtt  420
ccaaatcaa  ccagatttg  tcagggagt  tccagatgt  ttggaatgc  ctgtatctc  480
tgcagtaga  aagataaat  ctgatgaaa  agaagaaat  aaagtttct  caaaactgt  540
cattgtaga  tcaaactct  catcatcaa  tagaagtgc  gttgacatg  cctgttcag  600
ccttggagt  gcacagctg  attctgtga  cattgcttc  cctcctatt  aagatggag  660
taatctttc  ttggagcat  tacagcctt  ctgggagga  ttagaaaac  tagttcaga  720
caaaaagat  gttgccata  gtacctctg  tctagacaa  acacagttg  aacagctgt  780
tcagtgggc  caggtaaaa  caaatagta  ccaagttaa  cttgcctcc  gctgtgtga  840
gccaccaga  ttgactgca  ttgctaaac  atttgacat  cagctgttg  ctcacaatg  900
tccaaaaga  ctgctttct  aagcaagtt  ccaagaagc  cttcaggaa  gcattcctg  960
cattcaagc  cacgagtgg  tgccgctgt  gctactgcg  tattcggtc  ttgtgaaaa  1020
tagaggaat  atcaaatca  aaggctaca  tttacaagc  aaaagaagg  gttcttaac  1080
gacttagga  cataactta  ctgtaattt  cttcaatat  agagaaaat  gagatgtgt  1140
aaatctagt  actgcctgt  aatggtgtc  ttgaggcag  tattctttc  tcatatttg  1200
cagtatgtt  tctgtcaag  tttaaatac  tatcttgcc  ccatatcaa  ccattctca  1260
gaacctctg  attgctttc  ttaaactat  gttttctaa  tgaaattgt  tataaagaa  1320
atacttgca  tatattttt  ctttatttt  atgactaat  taaatcaag  aaatttgtt  1380
ttagatata  tttggccta  gtatcaggg  aatgtatat  catattttt  atttccaaa  1440
aaaattcat  aattgcttc  taactctta  tataaccaa  caatttaat  acaattgtt  1500
aaactgaaa  actggaaga  gatattttt  ctgtcattg  tgagatata  cagagtaac  1560
ggagtagct  ggatttact  gtagtgtaa  taaaattca  tcttcaatac  1610



<210> 7273
<211> 274
<212> PRT
<213> Homo sapiens
<308> P48507
<400> 7273

Met Gly Thr Asp Ser Arg Ala Ala Lys Ala Leu Leu Ala Arg Ala Arg 
  1               5                  10                  15
Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 
             20                  25                  30
Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu His Asp Cys Ile Gln 
         35                  40                  45
Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Asn Pro Asp Leu Val Arg 
     50                  55                  60
Glu Phe Pro Asp Val Leu Glu Cys Thr Val Ser His Ala Val Glu Lys 
 65                  70                  75                  80
Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 
                 85                  90                  95
Ile Val Glu Ser Asn Ser Ser Ser Ser Thr Arg Ser Ala Val Asp Met 
             100                105                110
Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Ile Ala 
         115                120                125
Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 
     130                135                140
Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 
 145                150                155                160
Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 
                 165                170                175
Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 
             180                185                190
Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 
         195                200                205
Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 
     210                215                220
Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Gln Ala His 
 225                230                235                240
Glu Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 
                 245                250                255
Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Arg 
             260                265                270
Gly Ser 
         275



<210> 7274
<211> 629
<212> DNA
<213> Rattus norvegicus
<308> AI233261
<400> 7274

catggatca  agaatcaat  ttatttaca  tactagtag  ctgctatag  tactctgag  60
tagattatt  tgtcaacga  aggaaaaaa  tctcttcca  tatgtctta  caactgtaa  120
gtaattgct  agttataga  gtatagagt  agaagcagc  actgaattt  agaaataaa  180
aatatgtat  tacatcacc  tgatgccta  gccaaaata  atcttaaaa  aaattttct  240
gatttctat  actcataaa  ataaaggaa  tatattgca  gtatttttc  ttatagacg  300
tttcagtta  aaaccaaga  tttaatgaa  agaatacaa  gcttcctgt  agtgcgctg  360
tgcagacgc  agggaggta  tcaaactca  cacattgcc  aaccaccac  ttcacgcct  420
agtgacgct  tttgtaggc  agagctaga  tttttttta  acatctcaa  tttatcatg  480
attttaatc  tatgttcca  ataaataca  ggcccctga  ttgtgagct  gagctgtag  540
taagaaccc  ttcttttgg  ttgcaaaat  tatcctttt  acttgatga  tcctctgct  600
ttcacgatg  ccgagtacc  naacagcca  629



<210> 7275
<211> 274
<212> PRT
<213> Rattus norvegicus
<308> P48508
<400> 7275

Met Gly Thr Asp Ser Arg Ala Ala Gly Ala Leu Leu Ala Arg Ala Ser 
  1               5                  10                  15
Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 
             20                  25                  30
Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu Arg Asp Cys Ile Gln 
         35                  40                  45
Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Ser Pro Asp Leu Val Arg 
     50                  55                  60
Glu Phe Pro Asp Val Leu Glu Cys Thr Met Ser His Ala Val Glu Lys 
 65                  70                  75                  80
Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 
                 85                  90                  95
Ile Val Gly Ser Asn Ser Ser Ser Ser Thr Arg Asn Ala Val Asp Met 
             100                105                110
Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Met Ala 
         115                120                125
Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 
     130                135                140
Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 
 145                150                155                160
Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 
                 165                170                175
Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 
             180                185                190
Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 
         195                200                205
Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 
     210                215                220
Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Glu Ala Gln 
 225                230                235                240
Glu Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 
                 245                250                255
Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Lys 
             260                265                270
Gly Ser 
         275



<210> 7276
<211> 1610
<212> DNA
<213> Homo sapiens
<308> L35546
<400> 7276

ggcacgagg  tgcggccgc  gtagccgga  ccggagccg  agccaccgg  gccttcctt  60
cccgccgcc  cccagccgc  gtccggcct  cctcgggcc  gagcgcaga  caggctcca  120
ccgcgcggc  ccggcagcc  cgcgctccc  ctcgggtct  tctcgggcc  cgggcaccg  180
gtcctgtgg  cggccgcct  cctgcccgc  cgcccgcag  cccttgcct  ccggcccct  240
ggcggcccg  gccatgggc  ccgacagcc  cgcggccaa  gcgctcctg  cgcgggccc  300
caccctgca  ctgcagacg  ggaacctgc  gaactgggg  cgcctgcgg  agaagtgcc  360
gtccacgca  agcgaggag  ttcatgatt  tatccaaaa  accttgaat  aatggagtt  420
ccaaatcaa  ccagatttg  tcagggagt  tccagatgt  ttggaatgc  ctgtatctc  480
tgcagtaga  aagataaat  ctgatgaaa  agaagaaat  aaagtttct  caaaactgt  540
cattgtaga  tcaaactct  catcatcaa  tagaagtgc  gttgacatg  cctgttcag  600
ccttggagt  gcacagctg  attctgtga  cattgcttc  cctcctatt  aagatggag  660
taatctttc  ttggagcat  tacagcctt  ctgggagga  ttagaaaac  tagttcaga  720
caaaaagat  gttgccata  gtacctctg  tctagacaa  acacagttg  aacagctgt  780
tcagtgggc  caggtaaaa  caaatagta  ccaagttaa  cttgcctcc  gctgtgtga  840
gccaccaga  ttgactgca  ttgctaaac  atttgacat  cagctgttg  ctcacaatg  900
tccaaaaga  ctgctttct  aagcaagtt  ccaagaagc  cttcaggaa  gcattcctg  960
cattcaagc  cacgagtgg  tgccgctgt  gctactgcg  tattcggtc  ttgtgaaaa  1020
tagaggaat  atcaaatca  aaggctaca  tttacaagc  aaaagaagg  gttcttaac  1080
gacttagga  cataactta  ctgtaattt  cttcaatat  agagaaaat  gagatgtgt  1140
aaatctagt  actgcctgt  aatggtgtc  ttgaggcag  tattctttc  tcatatttg  1200
cagtatgtt  tctgtcaag  tttaaatac  tatcttgcc  ccatatcaa  ccattctca  1260
gaacctctg  attgctttc  ttaaactat  gttttctaa  tgaaattgt  tataaagaa  1320
atacttgca  tatattttt  ctttatttt  atgactaat  taaatcaag  aaatttgtt  1380
ttagatata  tttggccta  gtatcaggg  aatgtatat  catattttt  atttccaaa  1440
aaaattcat  aattgcttc  taactctta  tataaccaa  caatttaat  acaattgtt  1500
aaactgaaa  actggaaga  gatattttt  ctgtcattg  tgagatata  cagagtaac  1560
ggagtagct  ggatttact  gtagtgtaa  taaaattca  tcttcaatac  1610



<210> 7277
<211> 274
<212> PRT
<213> Homo sapiens
<308> P48507
<400> 7277

Met Gly Thr Asp Ser Arg Ala Ala Lys Ala Leu Leu Ala Arg Ala Arg 
  1               5                  10                  15
Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 
             20                  25                  30
Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu His Asp Cys Ile Gln 
         35                  40                  45
Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Asn Pro Asp Leu Val Arg 
     50                  55                  60
Glu Phe Pro Asp Val Leu Glu Cys Thr Val Ser His Ala Val Glu Lys 
 65                  70                  75                  80
Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 
                 85                  90                  95
Ile Val Glu Ser Asn Ser Ser Ser Ser Thr Arg Ser Ala Val Asp Met 
             100                105                110
Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Ile Ala 
         115                120                125
Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 
     130                135                140
Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 
 145                150                155                160
Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 
                 165                170                175
Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 
             180                185                190
Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 
         195                200                205
Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 
     210                215                220
Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Gln Ala His 
 225                230                235                240
Glu Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 
                 245                250                255
Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Arg 
             260                265                270
Gly Ser 
         275



<210> 7278
<211> 501
<212> DNA
<213> Rattus norvegicus
<308> AI234950
<400> 7278

agacaagct  gaactttta  ttacactaa  agcaaagaa  ggatacaga  gaagggttt  60
gaagccata  tggggaagc  aagctctta  actcagttg  agtggggtg  gggccctgc  120
gccggacgc  agagaataa  cagaaaaag  gaaaaggaa  agtcaaggt  tacagttca  180
cagctgcat  tacttcaag  ccctgaaga  tccagccca  ctgagggag  gtcacgtca  240
gattccatg  gtttcactc  tgtgtcctc  cactgtcat  caggtgcag  accagtgtc  300
ttcaacctg  ctgaggttg  cactgacgg  agcctcagt  agagggaaa  tttgctgtt  360
ggtgatcca  ataaaatga  ccatttata  gaactgcaa  agtaccaag  gacaatgtg  420
tccaagcca  ttgccaaga  atgggctag  agacaaaga  caaggcttg  gggaagagc  480
agacagatc  agttccagc  t  501



<210> 7279
<211> 423
<212> PRT
<213> Rattus norvegicus
<308> P20611
<400> 7279

Met Ala Gly Arg Gln Ser Gly Trp Ser Gln Ala Ala Leu Leu Gln Phe 
  1               5                  10                  15
Leu Leu Gly Met Cys Leu Met Val Met Pro Pro Ile Gln Ala Arg Ser 
             20                  25                  30
Leu Arg Phe Val Thr Leu Leu Tyr Arg His Gly Asp Arg Ser Pro Val 
         35                  40                  45
Lys Ala Tyr Pro Lys Asp Pro Tyr Gln Glu Glu Lys Trp Pro Gln Gly 
     50                  55                  60
Phe Gly Gln Leu Thr Lys Glu Gly Met Leu Gln His Trp Glu Leu Gly 
 65                  70                  75                  80
Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn Ala Ser Tyr His 
                 85                  90                  95
Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp Arg Thr Leu Met 
             100                105                110
Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro Thr Glu Val Gln 
         115                120                125
His Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro Val His Thr Val 
     130                135                140
Pro Ile Thr Glu Asp Arg Leu Leu Lys Phe Pro Leu Gly Pro Cys Pro 
 145                150                155                160
Arg Tyr Glu Gln Leu Gln Asn Glu Thr Arg Gln Thr Pro Glu Tyr Gln 
                 165                170                175
Asn Met Ser Ile Gln Asn Ala Gln Phe Leu Asp Met Val Ala Asn Glu 
             180                185                190
Thr Gly Leu Met Asn Leu Thr Leu Glu Thr Ile Trp Asn Val Tyr Asp 
         195                200                205
Thr Leu Phe Cys Glu Gln Thr His Gly Leu Leu Leu Pro Pro Trp Ala 
     210                215                220
Ser Pro Gln Thr Val Gln Ala Leu Ser Gln Leu Lys Asp Phe Ser Phe 
 225                230                235                240
Leu Phe Leu Phe Gly Ile His Asp Gln Val Gln Lys Ala Arg Leu Gln 
                 245                250                255
Gly Gly Val Leu Leu Ala Gln Ile Leu Lys Asn Leu Thr Leu Met Ala 
             260                265                270
Thr Thr Ser Gln Phe Pro Lys Leu Leu Val Tyr Ser Ala His Asp Thr 
         275                280                285
Thr Leu Val Ala Leu Gln Met Ala Leu Asn Val Tyr Asn Gly Lys Gln 
     290                295                300
Ala Pro Tyr Ala Ser Cys His Ile Phe Glu Leu Tyr Gln Glu Asp Asn 
 305                310                315                320
Gly Asn Phe Ser Val Glu Met Tyr Phe Arg Asn Asp Ser Lys Lys Ala 
                 325                330                335
Pro Trp Pro Leu Thr Leu Pro Gly Cys Pro His Arg Cys Pro Leu Gln 
             340                345                350
Asp Phe Leu Arg Leu Thr Glu Pro Val Ile Pro Lys Asp Trp Gln Lys 
         355                360                365
Glu Cys Gln Leu Ala Ser Asp Thr Ala Asp Thr Glu Val Ile Val Ala 
     370                375                380
Leu Ala Val Cys Gly Ser Ile Leu Phe Leu Leu Ile Val Leu Leu Leu 
 385                390                395                400
Thr Val Leu Phe Arg Met Gln Ala Gln Pro Pro Gly Tyr His His Val 
                 405                410                415
Ala Asp Arg Glu Asp His Ala 
             420



<210> 7280
<211> 2111
<212> DNA
<213> Homo sapiens
<308> BC003160
<400> 7280

gtgatggcg  gcaagcggt  cggctggag  cgggcggct  tcctccagc  ccttctcgg  60
gtgaacctg  tggtgatgc  gcccaccca  gcccggagt  tgcgcttcg  taccttgct  120
taccgccat  gagaccgtt  accagtgaa  acatatccc  aggacccct  tcaggaaga  180
gaatggccc  aggggtttg  tcagttaac  aaggagggg  tgctacagc  ctgggaact  240
ggccaggcc  tgcggcagc  ctatcacgg  ttcctaaac  cctcttatc  ccggcaaga  300
gtttatgtg  gaagcacag  ctttgaccg  actctcatg  gtgctgagg  caacctggc  360
ggactcttc  ctcccaacg  gatgcagcg  ttcaacccg  acatctcgt  gcagcctat  420
cctgtgcac  ctgtgccca  cactgagga  aggctgctg  agttcccgt  gggcccatg  480
ccccgttat  agcagctac  gaacgagac  cggcagaca  cagagtatc  gaatgagag  540
tctcggaat  cacaatttc  ggacatggt  gccaacgag  cagggctta  agacctgac  600
ctggagacc  tctggaatg  ctatgacac  ctcttctgt  agcaaacgc  cgggctgcg  660
ctgccgccc  gggcctcac  ccaaaccat  cagcgtctc  gccggctaa  ggacttcag  720
ttccgcttc  tcttcggaa  ctaccagca  gcggagaag  cccggcttc  ggggggagt  780
ctgctggct  agataagga  gaacctgac  ctaatggcg  ccacctccc  gctccccaa  840
ctgctggtt  actctgcgc  cgacactac  ctggttgcc  tgcaaatgg  actggatgt  900
tacaatggt  aacaagccc  ctacgcctc  tgccacata  ttgaactgt  ccaggaaga  960
tctgggaat  tctcagtgg  gatgtactt  cggaacgag  gtgacaagg  cccctggcc  1020
ctcagcctg  ctggctgcc  tcaccgctg  ccactgcag  acttccttc  cctcacaga  1080
cccgtcgtg  ccaaggatt  gcagcagga  tgccagctg  caagcggtc  tgcagacac  1140
gaggtgatt  tggccttgg  tgtatgtgg  tccatcctc  tcctcctca  agtgctgct  1200
ctcaccgtc  tcttccgga  gcaggccca  cctcctggc  accgccacg  cgcagatgg  1260
gaggaccac  cctgacaac  actcagccc  cttccctcc  cctcctagg  gaggtgggc  1320
gggccctcg  tcctgactg  tgctgctcc  cagcccatg  acaggagat  ctgggttgg  1380
cctccctct  atgacccca  ccagatgag  gagtggggc  cagcgtggc  catggtgcc  1440
gtcactcag  attcccatg  ctgatgttt  ccaagtgct  tgttggaca  tggctttct  1500
caaacagga  ttgcctcct  cacgctccc  acacacctg  gatgtaaac  ggcagtcag  1560
gttcactca  gacctagga  tagaaaatg  cagagttgg  gctggatcc  ccttgcact  1620
ctatcaagc  ctgttcttt  tcctccagc  tgaagtctt  ggcaaatag  tcagaggga  1680
acggtcttg  ctctcagtg  ttattttag  gggaaaaac  gctaatacc  ggggtacaa  1740
cattggctc  caaggaact  gatcaccca  cagccagcc  gccacattt  cctgtgtct  1800
gctagagcc  ccattagac  cagacagaa  gcttcagga  tcgttgtca  cccttcaac  1860
ggagcagga  agaaggttg  ctgtacttg  gagggagtg  ggagtggtg  gaagggagt  1920
gcttgtcac  cgaatcagg  aactgctct  cctcagctg  gctggggtc  ccagggacc  1980
gagctacat  caggttgtg  gctggaaaa  aaagttcta  actgtggcc  agaataggg  2040
tggggcagc  cccagagaa  gaatagtgc  gtttcctat  ggactgata  aaaaaaaaa  2100
aaaaaaaaa  a  2111



<210> 7281
<211> 423
<212> PRT
<213> Homo sapiens
<308> P11117
<400> 7281

Met Ala Gly Lys Arg Ser Gly Trp Ser Arg Ala Ala Leu Leu Gln Leu 
  1               5                  10                  15
Leu Leu Gly Val Asn Leu Val Val Met Pro Pro Thr Arg Ala Arg Ser 
             20                  25                  30
Leu Arg Phe Val Thr Leu Leu Tyr Arg His Gly Asp Arg Ser Pro Val 
         35                  40                  45
Lys Thr Tyr Pro Lys Asp Pro Tyr Gln Glu Glu Glu Trp Pro Gln Gly 
     50                  55                  60
Phe Gly Gln Leu Thr Lys Glu Gly Met Leu Gln His Trp Glu Leu Gly 
 65                  70                  75                  80
Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn Thr Ser Tyr His 
                 85                  90                  95
Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp Arg Thr Leu Met 
             100                105                110
Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro Asn Gly Met Gln 
         115                120                125
Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro Val His Thr Val 
     130                135                140
Pro Ile Thr Glu Asp Arg Leu Leu Lys Phe Pro Leu Gly Pro Cys Pro 
 145                150                155                160
Arg Tyr Glu Gln Leu Gln Asn Glu Thr Arg Gln Thr Pro Glu Tyr Gln 
                 165                170                175
Asn Glu Ser Ser Arg Asn Ala Gln Phe Leu Asp Met Val Ala Asn Glu 
             180                185                190
Thr Gly Leu Thr Asp Leu Thr Leu Glu Thr Val Trp Asn Val Tyr Asp 
         195                200                205
Thr Leu Phe Cys Glu Gln Thr His Gly Leu Arg Leu Pro Pro Trp Ala 
     210                215                220
Ser Pro Gln Thr Met Gln Arg Leu Ser Arg Leu Lys Asp Phe Ser Phe 
 225                230                235                240
Arg Phe Leu Phe Gly Ile Tyr Gln Gln Ala Glu Lys Ala Arg Leu Gln 
                 245                250                255
Gly Gly Val Leu Leu Ala Gln Ile Arg Lys Asn Leu Thr Leu Met Ala 
             260                265                270
Thr Thr Ser Gln Leu Pro Lys Leu Leu Val Tyr Ser Ala His Asp Thr 
         275                280                285
Thr Leu Val Ala Leu Gln Met Ala Leu Asp Val Tyr Asn Gly Glu Gln 
     290                295                300
Ala Pro Tyr Ala Ser Cys His Ile Phe Glu Leu Tyr Gln Glu Asp Ser 
 305                310                315                320
Gly Asn Phe Ser Val Glu Met Tyr Phe Arg Asn Glu Ser Asp Lys Ala 
                 325                330                335
Pro Trp Pro Leu Ser Leu Pro Gly Cys Pro His Arg Cys Pro Leu Gln 
             340                345                350
Asp Phe Leu Arg Leu Thr Glu Pro Val Val Pro Lys Asp Trp Gln Gln 
         355                360                365
Glu Cys Gln Leu Ala Ser Gly Pro Ala Asp Thr Glu Val Ile Val Ala 
     370                375                380
Leu Ala Val Cys Gly Ser Ile Leu Phe Leu Leu Ile Val Leu Leu Leu 
 385                390                395                400
Thr Val Leu Phe Arg Met Gln Ala Gln Pro Pro Gly Tyr Arg His Val 
                 405                410                415
Ala Asp Gly Glu Asp His Ala 
             420



<210> 7282
<211> 554
<212> DNA
<213> Rattus norvegicus
<308> AI235358
<400> 7282

agaaatgta  ttttactgt  aacggggca  aatccagac  gttcaattg  tattatccc  60
aactgagca  gttttaaag  tgtttttat  ttaaaaagc  atcagtaat  atctggaat  120
ttttacttt  aaagctgct  agcctcaat  ttaacagat  ctgaaattt  ttaattgat  180
taattagtg  acttaatta  tctattact  ttttcttta  agcatttaa  aaatacctg  240
tgactgcct  ggaagagta  aagaaaaac  tttacatac  atgttttat  ggctctatg  300
cagctagga  gactatact  ttaagtttt  ttcttcatt  agaaaaatg  tgaattaac  360
ttaataatt  ggaaacctg  ctctgatgt  tttgctggt  tgggctgag  cttggatac  420
tgcatctgt  ataactcgt  aagaaaagg  gtatgtccc  agtttccac  tgctgtcat  480
gacttcttg  cagaaacaa  ctttttcgc  gcctttaca  aatcggcat  agccacagc  540
tcaatttgc  gaag  554



<210> 7283
<211> 1588
<212> DNA
<213> Homo sapiens
<308> J04973
<400> 7283

atcttgctt  cctttaatc  ggcagtgac  gtgtgtcag  acaatcttg  atcatgaag  60
tactaacca  agccggctc  ttctcgaga  tttattccc  caaagttgc  cccaaagtt  120
aagccacag  tgcgcctgc  ggagcaccg  cacaacctc  ggaccttga  tttaccaag  180
taccaaatg  cttggtgat  gcttctttg  aaaactatt  tcctgtatc  agaattggt  240
tgttcatta  agcaggcag  agatatgag  acttcagca  tttaggaac  acccatttg  300
tgcgtctta  atccagtct  acgacaaaa  gagcttcat  tttcaagat  acccgtgga  360
ttgaagcag  tggtggcaa  ttaagtgtg  ccgcaacaa  ggaaaacat  gcttatact  420
tggaatgcc  gcggggtga  gttgatatt  taatggagt  cctgctcaa  gtcaccaca  480
caccagaat  tcgtcgttg  gaagtagct  accttcagc  tcagctaaa  attgacaaa  540
ctgtggcct  tcagaatcc  cagactcat  tcattgaaa  tttgcatgc  gcagcttac  600
agaatgcct  ggctaatcc  ttgtattgt  ctgactata  gattggaaa  gtgacatca  660
aggagttac  ttacttcgt  cagaaccat  tcacaagtg  aagaatggc  ttgattgga  720
ttggtgtga  tcatcctgt  ctaaagcaa  ttgctgaac  gtttctcaa  atgaggggt  780
ggcttggtt  atctggtgc  aaggccaac  accgtggag  tgaaatccg  gaacagaat  840
gagacagtc  tgtccatgc  gcttttgta  cagaaagtg  tgtcgcggg  agtgcagag  900
caaatgcat  tagtgttct  cagcatgtc  tcggtgctg  gccacatgt  aagaggggc  960
gcaacacca  cagccatct  caccaggct  ttgccaagg  aactcagca  ccatttgat  1020
tttctgcat  taatgccag  tactcagat  ctggactct  tgggattta  actatctcc  1080
aggccacag  tgctggaga  gttatcaag  ctgcctata  tcaagtaaa  agaatagct  1140
aaggaaacc  ttccaacac  gatgtccaa  ctgccaaga  caagctgaa  gctggatac  1200
taatgtcag  ggagtcttc  gagtgtttc  tggaagaag  cgggtccca  gctctagtt  1260
ctggttctt  catgccacc  tccacagtc  ttcagcaga  tgattcagt  gctaatgct  1320
atatcataa  tgcggcaaa  aagtttgtt  ctggccaga  gtcaatggc  gcaagtgga  1380
atttgggac  tacaccttt  gttgatgag  tgtaatact  atgcacaca  tacaggaga  1440
agctgaacg  tctctcacc  agagcagca  acacatgaa  gtcagaagt  tctaatata  1500
catttgtct  ttttccagt  aggtaaaat  aggcataaa  gcaggtaat  attcccagc  1560
gacctaaag  caataaaac  ttctgttt  1588



<210> 7284
<211> 453
<212> PRT
<213> Homo sapiens
<308> P22695
<400> 7284

Met Lys Leu Leu Thr Arg Ala Gly Ser Phe Ser Arg Phe Tyr Ser Leu 
  1               5                  10                  15
Lys Val Ala Pro Lys Val Lys Ala Thr Ala Ala Pro Ala Gly Ala Pro 
             20                  25                  30
Pro Gln Pro Gln Asp Leu Glu Phe Thr Lys Leu Pro Asn Gly Leu Val 
         35                  40                  45
Ile Ala Ser Leu Glu Asn Tyr Ser Pro Val Ser Arg Ile Gly Leu Phe 
     50                  55                  60
Ile Lys Ala Gly Ser Arg Tyr Glu Asp Phe Ser Asn Leu Gly Thr Thr 
 65                  70                  75                  80
His Leu Leu Arg Leu Thr Ser Ser Leu Thr Thr Lys Gly Ala Ser Ser 
                 85                  90                  95
Phe Lys Ile Thr Arg Gly Ile Glu Ala Val Gly Gly Lys Leu Ser Val 
             100                105                110
Thr Ala Thr Arg Glu Asn Met Ala Tyr Thr Val Glu Cys Leu Arg Gly 
         115                120                125
Asp Val Asp Ile Leu Met Glu Phe Leu Leu Asn Val Thr Thr Ala Pro 
     130                135                140
Glu Phe Arg Arg Trp Glu Val Ala Asp Leu Gln Pro Gln Leu Lys Ile 
 145                150                155                160
Asp Lys Ala Val Ala Phe Gln Asn Pro Gln Thr His Val Ile Glu Asn 
                 165                170                175
Leu His Ala Ala Ala Tyr Arg Asn Ala Leu Ala Asn Pro Leu Tyr Cys 
             180                185                190
Pro Asp Tyr Arg Ile Gly Lys Val Thr Ser Glu Glu Leu His Tyr Phe 
         195                200                205
Val Gln Asn His Phe Thr Ser Ala Arg Met Ala Leu Ile Gly Leu Gly 
     210                215                220
Val Ser His Pro Val Leu Lys Gln Val Ala Glu Gln Phe Leu Asn Met 
 225                230                235                240
Arg Gly Gly Leu Gly Leu Ser Gly Ala Lys Ala Asn Tyr Arg Gly Gly 
                 245                250                255
Glu Ile Arg Glu Gln Asn Gly Asp Ser Leu Val His Ala Ala Phe Val 
             260                265                270
Ala Glu Ser Ala Val Ala Gly Ser Ala Glu Ala Asn Ala Phe Ser Val 
         275                280                285
Leu Gln His Val Leu Gly Ala Gly Pro His Val Lys Arg Gly Ser Asn 
     290                295                300
Thr Thr Ser His Leu His Gln Ala Val Ala Lys Ala Thr Gln Gln Pro 
 305                310                315                320
Phe Asp Val Ser Ala Phe Asn Ala Ser Tyr Ser Asp Ser Gly Leu Phe 
                 325                330                335
Gly Ile Tyr Thr Ile Ser Gln Ala Thr Ala Ala Gly Asp Val Ile Lys 
             340                345                350
Ala Ala Tyr Asn Gln Val Lys Thr Ile Ala Gln Gly Asn Leu Ser Asn 
         355                360                365
Thr Asp Val Gln Ala Ala Lys Asn Lys Leu Lys Ala Gly Tyr Leu Met 
     370                375                380
Ser Val Glu Ser Ser Glu Cys Phe Leu Glu Glu Val Gly Ser Gln Ala 
 385                390                395                400
Leu Val Ala Gly Ser Tyr Met Pro Pro Ser Thr Val Leu Gln Gln Ile 
                 405                410                415
Asp Ser Val Ala Asn Ala Asp Ile Ile Asn Ala Ala Lys Lys Phe Val 
             420                425                430
Ser Gly Gln Lys Ser Met Ala Ala Ser Gly Asn Leu Gly His Thr Pro 
         435                440                445
Phe Val Asp Glu Leu 
     450



<210> 7285
<211> 471
<212> DNA
<213> Rattus norvegicus
<308> AI235707
<400> 7285

aaaattgaa  aggactgct  tattgggtg  attttaaga  gcaactgtt  catgaactg  60
aaatgaaga  tttaaatat  ctacacaaa  gtcaaataa  tcatgctat  tgtcaatcc  120
cccataaat  cttttagcc  gtgttcaat  atagtcaat  ctgaattgg  ccatctctg  180
attagactt  ctaaagtct  cacagagta  aagaaatag  cactaatgg  aagtctgta  240
tctatcctg  agttggacc  tagaaagat  tccatcgac  aaatccaca  gccaggtaa  300
aggctttct  catagtggt  ttggctggg  cgtctggaa  ctgtgtgga  atgcttgta  360
ctcgggtgg  aagggtgtg  atgcatcca  gacagtcaa  gcagttggc  catctattc  420
ttgttaatt  ggcttcagc  gatggcatg  tttctaagc  gctgggaca  t  471



<210> 7286
<211> 591
<212> PRT
<213> Rattus norvegicus
<308> P35565
<400> 7286

Met Glu Gly Lys Trp Leu Leu Cys Leu Leu Leu Val Leu Gly Thr Ala 
  1               5                  10                  15
Ala Ile Gln Ala His Asp Gly His Asp Asp Asp Met Ile Asp Ile Glu 
             20                  25                  30
Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Ser Lys 
         35                  40                  45
Ser Asp Thr Ser Thr Pro Pro Ser Pro Lys Val Thr Tyr Lys Ala Pro 
     50                  55                  60
Val Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Ser 
 65                  70                  75                  80
Leu Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp 
                 85                  90                  95
Glu Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Asp Glu Met Lys Glu 
             100                105                110
Thr Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys 
         115                120                125
His His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr 
     130                135                140
Lys Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu 
 145                150                155                160
Cys Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Ser Glu Leu Asn 
                 165                170                175
Leu Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro 
             180                185                190
Asp Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys 
         195                200                205
Asn Pro Lys Thr Gly Val Tyr Glu Glu Lys His Ala Lys Arg Pro Asp 
     210                215                220
Ala Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr 
 225                230                235                240
Leu Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser 
                 245                250                255
Val Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn 
             260                265                270
Pro Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp 
         275                280                285
Asp Glu Arg Pro Lys Ile Ala Asp Pro Asp Ala Val Lys Pro Asp Asp 
     290                295                300
Trp Asp Glu Asp Ala Pro Ser Lys Ile Pro Asp Glu Glu Ala Thr Lys 
 305                310                315                320
Pro Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Ile Pro Asp Pro Asp 
                 325                330                335
Ala Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu 
             340                345                350
Ala Pro Gln Ile Ala Asn Pro Lys Cys Glu Ser Ala Pro Gly Cys Gly 
         355                360                365
Val Trp Gln Arg Pro Met Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp 
     370                375                380
Lys Pro Pro Met Ile Asp Asn Pro Asn Tyr Gln Gly Ile Trp Lys Pro 
 385                390                395                400
Arg Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg 
                 405                410                415
Met Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser 
             420                425                430
Asp Ile Phe Phe Asp Asn Phe Ile Ile Ser Gly Asp Arg Arg Val Val 
         435                440                445
Asp Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly 
     450                455                460
Ala Ala Glu Pro Gly Val Val Gly Gln Met Leu Glu Ala Ala Glu Glu 
 465                470                475                480
Arg Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val 
                 485                490                495
Phe Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Ser Asn Ala 
             500                505                510
Met Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Asp Glu 
         515                520                525
Glu Gly Lys Glu Glu Glu Lys Asn Lys Gly Asp Glu Glu Glu Glu Glu 
     530                535                540
Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly Gly 
 545                550                555                560
Thr Gly Ser Gln Asp Glu Glu Asp Ser Lys Pro Lys Ala Glu Glu Asp 
                 565                570                575
Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
             580                585                590



<210> 7287
<211> 4117
<212> DNA
<213> Homo sapiens
<308> L10284
<400> 7287

tccgcctct  tctttactg  ggcgcgggg  aaggtgtgc  ggcgggaag  ggcacgggc  60
cccccgcgg  ccccgggag  ctagagatc  tggaaggga  gtggttgct  tgtatgtta  120
tggtgcttg  aactgctat  gttgaggct  atgatggac  tgatgatga  gtgattgat  180
ttgaggatg  ccttgacga  gtcattgaa  aggtagaag  ctcaaaacc  gataccact  240
ctcctcctt  atctcccaa  gttacttac  aagctccag  tccaacagg  gaagtatat  300
ttgctgatt  ttttgacag  ggaactctg  cagggtgga  tttatccaa  gccaagaaa  360
acgataccg  tgatgaaat  gccaaatat  atggaaagt  ggaggtaga  gaaatgaag  420
agtcaaagc  tccaggtga  aaaggactt  tgttgatgt  tcgggccaa  catcatgcg  480
tctctgcta  actgaacaa  cccttcctg  ttgacacca  gcctctcat  gttcagtat  540
aggttaatt  ccaaaatgg  atagaatgt  gtggtgcct  tgtgaaact  ctttctaaa  600
caccagaac  caacctgga  cagttccat  acaagaccc  ttatacgat  atgtttggt  660
cagataaat  tggagagga  tataaactg  acttcatct  ccgacacaa  aaccccaaa  720
cgggtatct  tgaagaaaa  catgctaag  ggccagatg  agatctgaa  acctatttt  780
ctgataaga  aacacatct  tacacacta  tcttgaatc  agataatag  tttgaaata  840
tggttgacc  atctgtggt  aatagtgga  atctgctca  tgacatgac  cctcctgta  900
atccttcac  tgaaattga  gacccagaa  accggaagc  cgaggattg  gatgaaaga  960
caaaaatcc  agatccaga  gctgtcaag  cagatgact  ggatgaaga  gcccctgct  1020
agattccag  tgaagaggc  acaaaaccc  aaggctggt  agatgatga  cctgagtac  1080
tacctgatc  agacgcaga  aaacctgag  attgggatg  agacatgga  ggagaatgg  1140
aggctcctc  gattgccaa  cctagatgt  agtcagctc  tggatgtgg  gtctggcag  1200
gacctgtga  tgacaaccc  aattataaa  gcaaatgga  gcctcctat  attgacaat  1260
ccagttacc  gggaatctg  aaacccagg  aaataccaa  tccagattt  tttgaagat  1320
tggaacctt  cagaatgac  ccttttagt  ctattggtt  ggagctgtg  tccatgacc  1380
ctgacattt  ttttgacaa  tttatcatt  gtgctgatc  aagaatagt  gatgattgg  1440
ccaatgatg  atggggcct  aagaaagct  ctgatgggg  tgctgagcc  ggcgttgtg  1500
ggcagatga  cgaggcagc  gaagagcgc  cgtggctgt  ggtagtcta  attctaact  1560
tagcccttc  tgtgttcct  gttatcctc  tctgctgtt  tggaaagaa  cagaccagt  1620
gtatggagt  taagaaaac  gatgcacct  aaccggatg  gaaggaaga  gaagaagag  1680
aggaagagg  aaaggacaa  ggagatgag  aggaggaag  agaagagaa  cttgaagag  1740
aacagaaaa  tgatgctga  gaagatggt  gcactgtca  tcaagagga  gaagacaga  1800
aacctaaag  agaggagga  gaaattttg  acagatcac  aagaaacag  aagccacga  1860
gagagtgaa  caatcttaa  agcttgatc  gtgatttct  ctccctcct  ccctgcaag  1920
gtggtccta  gagaggacc  ggcacacct  aggttgaca  tcagaaaac  tcaagacat  1980
accatcagc  ggctccagt  gaacactag  ctgtgtaac  ttaaacatc  agcagtaaa  2040
acttgcagt  gtgatataa  ggaccctgt  tctgtagaa  agaaaacat  taacataat  2100
gttgtgaaa  gtaacatga  gcaaactaa  ttttttttt  ttaacatct  tgtttttaa  2160
atagaatga  agaactttg  cagtcttta  gatcttggc  taatttaat  tattaatct  2220
tttgtgcaa  cataatacc  ccatttaaa  atgttaggg  gatgagttg  agtttttat  2280
atagatttt  tttaaagtt  ggtattgta  aacattcac  cctctgtcc  tcaaaattg  2340
taattacgt  taaagtgca  tcatttgtg  ttagaatct  gttttgttt  cttccatta  2400
tgagttcct  ctaaggaaa  tgaggagag  gactgaata  aagcccaaa  tcatataaa  2460
gttgcgttt  agttgtatt  aaaatagat  tataagaaa  aattctttc  cttgatgtt  2520
gttagacca  aaagtgtgt  tgttctgta  ctcagttcc  agacagctt  ttaggtagt  2580
gaggaggtg  cttcatgtg  cacttgggc  tttatattc  acttgggag  gtcaggcct  2640
tggcttctg  agcaggtgg  ttgttaagg  acgctagca  ggcatggca  gtgagctcc  2700
gaatagatg  cttcatcac  tcttccact  tgtgttgac  ctgttttcc  tacctattt  2760
ctcagatcc  cagctttct  ctcgctatg  attttcttc  cagtgcagc  tgcagtccg  2820
tgctgaaaa  gattataag  cctgcataa  gttaagctt  attgtgatt  cgtgtatgt  2880
tcttctttc  tttaagcag  cccatacct  tccagggtc  aagtacaga  tagaataca  2940
tgatacaaa  tacagaaaa  tactttgat  tttatccat  tcttttact  tgtgtaaag  3000
ctttagaag  ctaattcac  ggcaaacca  tacagaatt  actgcagtt  aacagacta  3060
aagtatttg  gggaggagt  acatgaagc  tgagttatc  gattttttt  gtagctgct  3120
tatatttta  gccttcatt  gcaattcat  taacagttg  gtcataaat  acacaataa  3180
gcagtcctg  tcaaatttt  ttttaacgt  gcttgtaga  tttttaaaa  agtgatctt  3240
ggtttgttt  ttcatgcgg  atgcagatg  gtgctatca  agcctctcc  acaccacta  3300
agtgtaata  tgttattat  actctacac  gaaacgtat  cagagttag  tattatttt  3360
gcttcagtt  ttctttaga  gctttcaaa  gtaccgatg  tactgtttc  tgcactgaa  3420
atataaaca  tccacagtg  ttatattgg  aagatattg  gaaggaaat  tatttgtaa  3480
agatgaagg  tgtatctat  tttttttct  tttaaactg  ttcacttaa  ttcttttga  3540
gatgggatg  atttttctt  ctgttcagt  ctttttcct  ttcatctgt  gttctgtgg  3600
cacagtgac  ttagctaca  agcagactt  cccaaatgt  ttgattaca  ataaacagt  3660
gttacttag  aagacctga  aatatgtct  caggtttct  cttgaagca  atgtgtggg  3720
tcattgcat  tccagaaat  tgcctcctt  acccaccgt  gacagtata  gtcatgcct  3780
actttcttg  agctgagct  taaatcatt  gagcttaaa  tgtcagatc  ttcattgcc  3840
ttccagggt  atttagtaa  gtttgttga  aacaaaaac  ccttttctt  gttcttttt  3900
cagttattt  gaaggtcca  catcctgat  aaatgtctg  cacttaatg  atgaccagc  3960
gcagctttc  gctcttaaa  agacactta  attttgatt  tacatgctg  ttacctgtt  4020
cattgttgt  aaatgccca  tgtccatca  atgtgttcc  ccattttct  atccacaaa  4080
tactcctca  ttttcaatt  gtcatgtta  taaaccc  4117



<210> 7288
<211> 592
<212> PRT
<213> Homo sapiens
<308> P27824
<400> 7288

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
  1               5                  10                  15
Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
             20                  25                  30
Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
         35                  40                  45
Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
     50                  55                  60
Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
 65                  70                  75                  80
Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                 85                  90                  95
Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
             100                105                110
Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
         115                120                125
His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
     130                135                140
Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
 145                150                155                160
Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu 
                 165                170                175
Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp 
             180                185                190
Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn 
         195                200                205
Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala 
     210                215                220
Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu 
 225                230                235                240
Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val 
                 245                250                255
Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro 
             260                265                270
Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp 
         275                280                285
Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp 
     290                295                300
Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro 
 305                310                315                320
Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala 
                 325                330                335
Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala 
             340                345                350
Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val 
         355                360                365
Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys 
     370                375                380
Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg 
 385                390                395                400
Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met 
                 405                410                415
Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp 
             420                425                430
Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp 
         435                440                445
Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala 
     450                455                460
Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg 
 465                470                475                480
Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe 
                 485                490                495
Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met 
             500                505                510
Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu 
         515                520                525
Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly 
     530                535                540
Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly 
 545                550                555                560
Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu 
                 565                570                575
Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
             580                585                590



<210> 7289
<211> 471
<212> DNA
<213> Rattus norvegicus
<308> AI235707
<400> 7289

aaaattgaa  aggactgct  tattgggtg  attttaaga  gcaactgtt  catgaactg  60
aaatgaaga  tttaaatat  ctacacaaa  gtcaaataa  tcatgctat  tgtcaatcc  120
cccataaat  cttttagcc  gtgttcaat  atagtcaat  ctgaattgg  ccatctctg  180
attagactt  ctaaagtct  cacagagta  aagaaatag  cactaatgg  aagtctgta  240
tctatcctg  agttggacc  tagaaagat  tccatcgac  aaatccaca  gccaggtaa  300
aggctttct  catagtggt  ttggctggg  cgtctggaa  ctgtgtgga  atgcttgta  360
ctcgggtgg  aagggtgtg  atgcatcca  gacagtcaa  gcagttggc  catctattc  420
ttgttaatt  ggcttcagc  gatggcatg  tttctaagc  gctgggaca  t  471



<210> 7290
<211> 591
<212> PRT
<213> Rattus norvegicus
<308> P35565
<400> 7290

Met Glu Gly Lys Trp Leu Leu Cys Leu Leu Leu Val Leu Gly Thr Ala 
  1               5                  10                  15
Ala Ile Gln Ala His Asp Gly His Asp Asp Asp Met Ile Asp Ile Glu 
             20                  25                  30
Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Ser Lys 
         35                  40                  45
Ser Asp Thr Ser Thr Pro Pro Ser Pro Lys Val Thr Tyr Lys Ala Pro 
     50                  55                  60
Val Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Ser 
 65                  70                  75                  80
Leu Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp 
                 85                  90                  95
Glu Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Asp Glu Met Lys Glu 
             100                105                110
Thr Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys 
         115                120                125
His His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr 
     130                135                140
Lys Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu 
 145                150                155                160
Cys Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Ser Glu Leu Asn 
                 165                170                175
Leu Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro 
             180                185                190
Asp Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys 
         195                200                205
Asn Pro Lys Thr Gly Val Tyr Glu Glu Lys His Ala Lys Arg Pro Asp 
     210                215                220
Ala Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr 
 225                230                235                240
Leu Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser 
                 245                250                255
Val Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn 
             260                265                270
Pro Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp 
         275                280                285
Asp Glu Arg Pro Lys Ile Ala Asp Pro Asp Ala Val Lys Pro Asp Asp 
     290                295                300
Trp Asp Glu Asp Ala Pro Ser Lys Ile Pro Asp Glu Glu Ala Thr Lys 
 305                310                315                320
Pro Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Ile Pro Asp Pro Asp 
                 325                330                335
Ala Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu 
             340                345                350
Ala Pro Gln Ile Ala Asn Pro Lys Cys Glu Ser Ala Pro Gly Cys Gly 
         355                360                365
Val Trp Gln Arg Pro Met Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp 
     370                375                380
Lys Pro Pro Met Ile Asp Asn Pro Asn Tyr Gln Gly Ile Trp Lys Pro 
 385                390                395                400
Arg Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg 
                 405                410                415
Met Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser 
             420                425                430
Asp Ile Phe Phe Asp Asn Phe Ile Ile Ser Gly Asp Arg Arg Val Val 
         435                440                445
Asp Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly 
     450                455                460
Ala Ala Glu Pro Gly Val Val Gly Gln Met Leu Glu Ala Ala Glu Glu 
 465                470                475                480
Arg Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val 
                 485                490                495
Phe Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Ser Asn Ala 
             500                505                510
Met Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Asp Glu 
         515                520                525
Glu Gly Lys Glu Glu Glu Lys Asn Lys Gly Asp Glu Glu Glu Glu Glu 
     530                535                540
Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly Gly 
 545                550                555                560
Thr Gly Ser Gln Asp Glu Glu Asp Ser Lys Pro Lys Ala Glu Glu Asp 
                 565                570                575
Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
             580                585                590



<210> 7291
<211> 4117
<212> DNA
<213> Homo sapiens
<308> L10284
<400> 7291

tccgcctct  tctttactg  ggcgcgggg  aaggtgtgc  ggcgggaag  ggcacgggc  60
cccccgcgg  ccccgggag  ctagagatc  tggaaggga  gtggttgct  tgtatgtta  120
tggtgcttg  aactgctat  gttgaggct  atgatggac  tgatgatga  gtgattgat  180
ttgaggatg  ccttgacga  gtcattgaa  aggtagaag  ctcaaaacc  gataccact  240
ctcctcctt  atctcccaa  gttacttac  aagctccag  tccaacagg  gaagtatat  300
ttgctgatt  ttttgacag  ggaactctg  cagggtgga  tttatccaa  gccaagaaa  360
acgataccg  tgatgaaat  gccaaatat  atggaaagt  ggaggtaga  gaaatgaag  420
agtcaaagc  tccaggtga  aaaggactt  tgttgatgt  tcgggccaa  catcatgcg  480
tctctgcta  actgaacaa  cccttcctg  ttgacacca  gcctctcat  gttcagtat  540
aggttaatt  ccaaaatgg  atagaatgt  gtggtgcct  tgtgaaact  ctttctaaa  600
caccagaac  caacctgga  cagttccat  acaagaccc  ttatacgat  atgtttggt  660
cagataaat  tggagagga  tataaactg  acttcatct  ccgacacaa  aaccccaaa  720
cgggtatct  tgaagaaaa  catgctaag  ggccagatg  agatctgaa  acctatttt  780
ctgataaga  aacacatct  tacacacta  tcttgaatc  agataatag  tttgaaata  840
tggttgacc  atctgtggt  aatagtgga  atctgctca  tgacatgac  cctcctgta  900
atccttcac  tgaaattga  gacccagaa  accggaagc  cgaggattg  gatgaaaga  960
caaaaatcc  agatccaga  gctgtcaag  cagatgact  ggatgaaga  gcccctgct  1020
agattccag  tgaagaggc  acaaaaccc  aaggctggt  agatgatga  cctgagtac  1080
tacctgatc  agacgcaga  aaacctgag  attgggatg  agacatgga  ggagaatgg  1140
aggctcctc  gattgccaa  cctagatgt  agtcagctc  tggatgtgg  gtctggcag  1200
gacctgtga  tgacaaccc  aattataaa  gcaaatgga  gcctcctat  attgacaat  1260
ccagttacc  gggaatctg  aaacccagg  aaataccaa  tccagattt  tttgaagat  1320
tggaacctt  cagaatgac  ccttttagt  ctattggtt  ggagctgtg  tccatgacc  1380
ctgacattt  ttttgacaa  tttatcatt  gtgctgatc  aagaatagt  gatgattgg  1440
ccaatgatg  atggggcct  aagaaagct  ctgatgggg  tgctgagcc  ggcgttgtg  1500
ggcagatga  cgaggcagc  gaagagcgc  cgtggctgt  ggtagtcta  attctaact  1560
tagcccttc  tgtgttcct  gttatcctc  tctgctgtt  tggaaagaa  cagaccagt  1620
gtatggagt  taagaaaac  gatgcacct  aaccggatg  gaaggaaga  gaagaagag  1680
aggaagagg  aaaggacaa  ggagatgag  aggaggaag  agaagagaa  cttgaagag  1740
aacagaaaa  tgatgctga  gaagatggt  gcactgtca  tcaagagga  gaagacaga  1800
aacctaaag  agaggagga  gaaattttg  acagatcac  aagaaacag  aagccacga  1860
gagagtgaa  caatcttaa  agcttgatc  gtgatttct  ctccctcct  ccctgcaag  1920
gtggtccta  gagaggacc  ggcacacct  aggttgaca  tcagaaaac  tcaagacat  1980
accatcagc  ggctccagt  gaacactag  ctgtgtaac  ttaaacatc  agcagtaaa  2040
acttgcagt  gtgatataa  ggaccctgt  tctgtagaa  agaaaacat  taacataat  2100
gttgtgaaa  gtaacatga  gcaaactaa  ttttttttt  ttaacatct  tgtttttaa  2160
atagaatga  agaactttg  cagtcttta  gatcttggc  taatttaat  tattaatct  2220
tttgtgcaa  cataatacc  ccatttaaa  atgttaggg  gatgagttg  agtttttat  2280
atagatttt  tttaaagtt  ggtattgta  aacattcac  cctctgtcc  tcaaaattg  2340
taattacgt  taaagtgca  tcatttgtg  ttagaatct  gttttgttt  cttccatta  2400
tgagttcct  ctaaggaaa  tgaggagag  gactgaata  aagcccaaa  tcatataaa  2460
gttgcgttt  agttgtatt  aaaatagat  tataagaaa  aattctttc  cttgatgtt  2520
gttagacca  aaagtgtgt  tgttctgta  ctcagttcc  agacagctt  ttaggtagt  2580
gaggaggtg  cttcatgtg  cacttgggc  tttatattc  acttgggag  gtcaggcct  2640
tggcttctg  agcaggtgg  ttgttaagg  acgctagca  ggcatggca  gtgagctcc  2700
gaatagatg  cttcatcac  tcttccact  tgtgttgac  ctgttttcc  tacctattt  2760
ctcagatcc  cagctttct  ctcgctatg  attttcttc  cagtgcagc  tgcagtccg  2820
tgctgaaaa  gattataag  cctgcataa  gttaagctt  attgtgatt  cgtgtatgt  2880
tcttctttc  tttaagcag  cccatacct  tccagggtc  aagtacaga  tagaataca  2940
tgatacaaa  tacagaaaa  tactttgat  tttatccat  tcttttact  tgtgtaaag  3000
ctttagaag  ctaattcac  ggcaaacca  tacagaatt  actgcagtt  aacagacta  3060
aagtatttg  gggaggagt  acatgaagc  tgagttatc  gattttttt  gtagctgct  3120
tatatttta  gccttcatt  gcaattcat  taacagttg  gtcataaat  acacaataa  3180
gcagtcctg  tcaaatttt  ttttaacgt  gcttgtaga  tttttaaaa  agtgatctt  3240
ggtttgttt  ttcatgcgg  atgcagatg  gtgctatca  agcctctcc  acaccacta  3300
agtgtaata  tgttattat  actctacac  gaaacgtat  cagagttag  tattatttt  3360
gcttcagtt  ttctttaga  gctttcaaa  gtaccgatg  tactgtttc  tgcactgaa  3420
atataaaca  tccacagtg  ttatattgg  aagatattg  gaaggaaat  tatttgtaa  3480
agatgaagg  tgtatctat  tttttttct  tttaaactg  ttcacttaa  ttcttttga  3540
gatgggatg  atttttctt  ctgttcagt  ctttttcct  ttcatctgt  gttctgtgg  3600
cacagtgac  ttagctaca  agcagactt  cccaaatgt  ttgattaca  ataaacagt  3660
gttacttag  aagacctga  aatatgtct  caggtttct  cttgaagca  atgtgtggg  3720
tcattgcat  tccagaaat  tgcctcctt  acccaccgt  gacagtata  gtcatgcct  3780
actttcttg  agctgagct  taaatcatt  gagcttaaa  tgtcagatc  ttcattgcc  3840
ttccagggt  atttagtaa  gtttgttga  aacaaaaac  ccttttctt  gttcttttt  3900
cagttattt  gaaggtcca  catcctgat  aaatgtctg  cacttaatg  atgaccagc  3960
gcagctttc  gctcttaaa  agacactta  attttgatt  tacatgctg  ttacctgtt  4020
cattgttgt  aaatgccca  tgtccatca  atgtgttcc  ccattttct  atccacaaa  4080
tactcctca  ttttcaatt  gtcatgtta  taaaccc  4117



<210> 7292
<211> 592
<212> PRT
<213> Homo sapiens
<308> P27824
<400> 7292

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
  1               5                  10                  15
Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
             20                  25                  30
Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
         35                  40                  45
Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
     50                  55                  60
Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
 65                  70                  75                  80
Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                 85                  90                  95
Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
             100                105                110
Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
         115                120                125
His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
     130                135                140
Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
 145                150                155                160
Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu 
                 165                170                175
Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp 
             180                185                190
Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn 
         195                200                205
Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala 
     210                215                220
Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu 
 225                230                235                240
Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val 
                 245                250                255
Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro 
             260                265                270
Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp 
         275                280                285
Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp 
     290                295                300
Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro 
 305                310                315                320
Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala 
                 325                330                335
Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala 
             340                345                350
Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val 
         355                360                365
Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys 
     370                375                380
Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg 
 385                390                395                400
Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met 
                 405                410                415
Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp 
             420                425                430
Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp 
         435                440                445
Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala 
     450                455                460
Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg 
 465                470                475                480
Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe 
                 485                490                495
Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met 
             500                505                510
Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu 
         515                520                525
Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly 
     530                535                540
Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly 
 545                550                555                560
Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu 
                 565                570                575
Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
             580                585                590



<210> 7293
<211> 471
<212> DNA
<213> Rattus norvegicus
<308> AI235707
<400> 7293

aaaattgaa  aggactgct  tattgggtg  attttaaga  gcaactgtt  catgaactg  60
aaatgaaga  tttaaatat  ctacacaaa  gtcaaataa  tcatgctat  tgtcaatcc  120
cccataaat  cttttagcc  gtgttcaat  atagtcaat  ctgaattgg  ccatctctg  180
attagactt  ctaaagtct  cacagagta  aagaaatag  cactaatgg  aagtctgta  240
tctatcctg  agttggacc  tagaaagat  tccatcgac  aaatccaca  gccaggtaa  300
aggctttct  catagtggt  ttggctggg  cgtctggaa  ctgtgtgga  atgcttgta  360
ctcgggtgg  aagggtgtg  atgcatcca  gacagtcaa  gcagttggc  catctattc  420
ttgttaatt  ggcttcagc  gatggcatg  tttctaagc  gctgggaca  t  471



<210> 7294
<211> 591
<212> PRT
<213> Rattus norvegicus
<308> P35565
<400> 7294

Met Glu Gly Lys Trp Leu Leu Cys Leu Leu Leu Val Leu Gly Thr Ala 
  1               5                  10                  15
Ala Ile Gln Ala His Asp Gly His Asp Asp Asp Met Ile Asp Ile Glu 
             20                  25                  30
Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Ser Lys 
         35                  40                  45
Ser Asp Thr Ser Thr Pro Pro Ser Pro Lys Val Thr Tyr Lys Ala Pro 
     50                  55                  60
Val Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Ser 
 65                  70                  75                  80
Leu Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp 
                 85                  90                  95
Glu Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Asp Glu Met Lys Glu 
             100                105                110
Thr Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys 
         115                120                125
His His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr 
     130                135                140
Lys Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu 
 145                150                155                160
Cys Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Ser Glu Leu Asn 
                 165                170                175
Leu Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro 
             180                185                190
Asp Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys 
         195                200                205
Asn Pro Lys Thr Gly Val Tyr Glu Glu Lys His Ala Lys Arg Pro Asp 
     210                215                220
Ala Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr 
 225                230                235                240
Leu Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser 
                 245                250                255
Val Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn 
             260                265                270
Pro Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp 
         275                280                285
Asp Glu Arg Pro Lys Ile Ala Asp Pro Asp Ala Val Lys Pro Asp Asp 
     290                295                300
Trp Asp Glu Asp Ala Pro Ser Lys Ile Pro Asp Glu Glu Ala Thr Lys 
 305                310                315                320
Pro Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Ile Pro Asp Pro Asp 
                 325                330                335
Ala Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu 
             340                345                350
Ala Pro Gln Ile Ala Asn Pro Lys Cys Glu Ser Ala Pro Gly Cys Gly 
         355                360                365
Val Trp Gln Arg Pro Met Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp 
     370                375                380
Lys Pro Pro Met Ile Asp Asn Pro Asn Tyr Gln Gly Ile Trp Lys Pro 
 385                390                395                400
Arg Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg 
                 405                410                415
Met Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser 
             420                425                430
Asp Ile Phe Phe Asp Asn Phe Ile Ile Ser Gly Asp Arg Arg Val Val 
         435                440                445
Asp Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly 
     450                455                460
Ala Ala Glu Pro Gly Val Val Gly Gln Met Leu Glu Ala Ala Glu Glu 
 465                470                475                480
Arg Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val 
                 485                490                495
Phe Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Ser Asn Ala 
             500                505                510
Met Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Asp Glu 
         515                520                525
Glu Gly Lys Glu Glu Glu Lys Asn Lys Gly Asp Glu Glu Glu Glu Glu 
     530                535                540
Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly Gly 
 545                550                555                560
Thr Gly Ser Gln Asp Glu Glu Asp Ser Lys Pro Lys Ala Glu Glu Asp 
                 565                570                575
Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
             580                585                590



<210> 7295
<211> 4117
<212> DNA
<213> Homo sapiens
<308> L10284
<400> 7295

tccgcctct  tctttactg  ggcgcgggg  aaggtgtgc  ggcgggaag  ggcacgggc  60
cccccgcgg  ccccgggag  ctagagatc  tggaaggga  gtggttgct  tgtatgtta  120
tggtgcttg  aactgctat  gttgaggct  atgatggac  tgatgatga  gtgattgat  180
ttgaggatg  ccttgacga  gtcattgaa  aggtagaag  ctcaaaacc  gataccact  240
ctcctcctt  atctcccaa  gttacttac  aagctccag  tccaacagg  gaagtatat  300
ttgctgatt  ttttgacag  ggaactctg  cagggtgga  tttatccaa  gccaagaaa  360
acgataccg  tgatgaaat  gccaaatat  atggaaagt  ggaggtaga  gaaatgaag  420
agtcaaagc  tccaggtga  aaaggactt  tgttgatgt  tcgggccaa  catcatgcg  480
tctctgcta  actgaacaa  cccttcctg  ttgacacca  gcctctcat  gttcagtat  540
aggttaatt  ccaaaatgg  atagaatgt  gtggtgcct  tgtgaaact  ctttctaaa  600
caccagaac  caacctgga  cagttccat  acaagaccc  ttatacgat  atgtttggt  660
cagataaat  tggagagga  tataaactg  acttcatct  ccgacacaa  aaccccaaa  720
cgggtatct  tgaagaaaa  catgctaag  ggccagatg  agatctgaa  acctatttt  780
ctgataaga  aacacatct  tacacacta  tcttgaatc  agataatag  tttgaaata  840
tggttgacc  atctgtggt  aatagtgga  atctgctca  tgacatgac  cctcctgta  900
atccttcac  tgaaattga  gacccagaa  accggaagc  cgaggattg  gatgaaaga  960
caaaaatcc  agatccaga  gctgtcaag  cagatgact  ggatgaaga  gcccctgct  1020
agattccag  tgaagaggc  acaaaaccc  aaggctggt  agatgatga  cctgagtac  1080
tacctgatc  agacgcaga  aaacctgag  attgggatg  agacatgga  ggagaatgg  1140
aggctcctc  gattgccaa  cctagatgt  agtcagctc  tggatgtgg  gtctggcag  1200
gacctgtga  tgacaaccc  aattataaa  gcaaatgga  gcctcctat  attgacaat  1260
ccagttacc  gggaatctg  aaacccagg  aaataccaa  tccagattt  tttgaagat  1320
tggaacctt  cagaatgac  ccttttagt  ctattggtt  ggagctgtg  tccatgacc  1380
ctgacattt  ttttgacaa  tttatcatt  gtgctgatc  aagaatagt  gatgattgg  1440
ccaatgatg  atggggcct  aagaaagct  ctgatgggg  tgctgagcc  ggcgttgtg  1500
ggcagatga  cgaggcagc  gaagagcgc  cgtggctgt  ggtagtcta  attctaact  1560
tagcccttc  tgtgttcct  gttatcctc  tctgctgtt  tggaaagaa  cagaccagt  1620
gtatggagt  taagaaaac  gatgcacct  aaccggatg  gaaggaaga  gaagaagag  1680
aggaagagg  aaaggacaa  ggagatgag  aggaggaag  agaagagaa  cttgaagag  1740
aacagaaaa  tgatgctga  gaagatggt  gcactgtca  tcaagagga  gaagacaga  1800
aacctaaag  agaggagga  gaaattttg  acagatcac  aagaaacag  aagccacga  1860
gagagtgaa  caatcttaa  agcttgatc  gtgatttct  ctccctcct  ccctgcaag  1920
gtggtccta  gagaggacc  ggcacacct  aggttgaca  tcagaaaac  tcaagacat  1980
accatcagc  ggctccagt  gaacactag  ctgtgtaac  ttaaacatc  agcagtaaa  2040
acttgcagt  gtgatataa  ggaccctgt  tctgtagaa  agaaaacat  taacataat  2100
gttgtgaaa  gtaacatga  gcaaactaa  ttttttttt  ttaacatct  tgtttttaa  2160
atagaatga  agaactttg  cagtcttta  gatcttggc  taatttaat  tattaatct  2220
tttgtgcaa  cataatacc  ccatttaaa  atgttaggg  gatgagttg  agtttttat  2280
atagatttt  tttaaagtt  ggtattgta  aacattcac  cctctgtcc  tcaaaattg  2340
taattacgt  taaagtgca  tcatttgtg  ttagaatct  gttttgttt  cttccatta  2400
tgagttcct  ctaaggaaa  tgaggagag  gactgaata  aagcccaaa  tcatataaa  2460
gttgcgttt  agttgtatt  aaaatagat  tataagaaa  aattctttc  cttgatgtt  2520
gttagacca  aaagtgtgt  tgttctgta  ctcagttcc  agacagctt  ttaggtagt  2580
gaggaggtg  cttcatgtg  cacttgggc  tttatattc  acttgggag  gtcaggcct  2640
tggcttctg  agcaggtgg  ttgttaagg  acgctagca  ggcatggca  gtgagctcc  2700
gaatagatg  cttcatcac  tcttccact  tgtgttgac  ctgttttcc  tacctattt  2760
ctcagatcc  cagctttct  ctcgctatg  attttcttc  cagtgcagc  tgcagtccg  2820
tgctgaaaa  gattataag  cctgcataa  gttaagctt  attgtgatt  cgtgtatgt  2880
tcttctttc  tttaagcag  cccatacct  tccagggtc  aagtacaga  tagaataca  2940
tgatacaaa  tacagaaaa  tactttgat  tttatccat  tcttttact  tgtgtaaag  3000
ctttagaag  ctaattcac  ggcaaacca  tacagaatt  actgcagtt  aacagacta  3060
aagtatttg  gggaggagt  acatgaagc  tgagttatc  gattttttt  gtagctgct  3120
tatatttta  gccttcatt  gcaattcat  taacagttg  gtcataaat  acacaataa  3180
gcagtcctg  tcaaatttt  ttttaacgt  gcttgtaga  tttttaaaa  agtgatctt  3240
ggtttgttt  ttcatgcgg  atgcagatg  gtgctatca  agcctctcc  acaccacta  3300
agtgtaata  tgttattat  actctacac  gaaacgtat  cagagttag  tattatttt  3360
gcttcagtt  ttctttaga  gctttcaaa  gtaccgatg  tactgtttc  tgcactgaa  3420
atataaaca  tccacagtg  ttatattgg  aagatattg  gaaggaaat  tatttgtaa  3480
agatgaagg  tgtatctat  tttttttct  tttaaactg  ttcacttaa  ttcttttga  3540
gatgggatg  atttttctt  ctgttcagt  ctttttcct  ttcatctgt  gttctgtgg  3600
cacagtgac  ttagctaca  agcagactt  cccaaatgt  ttgattaca  ataaacagt  3660
gttacttag  aagacctga  aatatgtct  caggtttct  cttgaagca  atgtgtggg  3720
tcattgcat  tccagaaat  tgcctcctt  acccaccgt  gacagtata  gtcatgcct  3780
actttcttg  agctgagct  taaatcatt  gagcttaaa  tgtcagatc  ttcattgcc  3840
ttccagggt  atttagtaa  gtttgttga  aacaaaaac  ccttttctt  gttcttttt  3900
cagttattt  gaaggtcca  catcctgat  aaatgtctg  cacttaatg  atgaccagc  3960
gcagctttc  gctcttaaa  agacactta  attttgatt  tacatgctg  ttacctgtt  4020
cattgttgt  aaatgccca  tgtccatca  atgtgttcc  ccattttct  atccacaaa  4080
tactcctca  ttttcaatt  gtcatgtta  taaaccc  4117



<210> 7296
<211> 592
<212> PRT
<213> Homo sapiens
<308> P27824
<400> 7296

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
  1               5                  10                  15
Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
             20                  25                  30
Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
         35                  40                  45
Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
     50                  55                  60
Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
 65                  70                  75                  80
Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                 85                  90                  95
Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
             100                105                110
Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
         115                120                125
His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
     130                135                140
Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
 145                150                155                160
Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu 
                 165                170                175
Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp 
             180                185                190
Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn 
         195                200                205
Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala 
     210                215                220
Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu 
 225                230                235                240
Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val 
                 245                250                255
Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro 
             260                265                270
Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp 
         275                280                285
Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp 
     290                295                300
Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro 
 305                310                315                320
Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala 
                 325                330                335
Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala 
             340                345                350
Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val 
         355                360                365
Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys 
     370                375                380
Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg 
 385                390                395                400
Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met 
                 405                410                415
Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp 
             420                425                430
Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp 
         435                440                445
Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala 
     450                455                460
Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg 
 465                470                475                480
Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe 
                 485                490                495
Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met 
             500                505                510
Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu 
         515                520                525
Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly 
     530                535                540
Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly 
 545                550                555                560
Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu 
                 565                570                575
Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
             580                585                590



<210> 7297
<211> 471
<212> DNA
<213> Rattus norvegicus
<308> AI235707
<400> 7297

aaaattgaa  aggactgct  tattgggtg  attttaaga  gcaactgtt  catgaactg  60
aaatgaaga  tttaaatat  ctacacaaa  gtcaaataa  tcatgctat  tgtcaatcc  120
cccataaat  cttttagcc  gtgttcaat  atagtcaat  ctgaattgg  ccatctctg  180
attagactt  ctaaagtct  cacagagta  aagaaatag  cactaatgg  aagtctgta  240
tctatcctg  agttggacc  tagaaagat  tccatcgac  aaatccaca  gccaggtaa  300
aggctttct  catagtggt  ttggctggg  cgtctggaa  ctgtgtgga  atgcttgta  360
ctcgggtgg  aagggtgtg  atgcatcca  gacagtcaa  gcagttggc  catctattc  420
ttgttaatt  ggcttcagc  gatggcatg  tttctaagc  gctgggaca  t  471



<210> 7298
<211> 591
<212> PRT
<213> Rattus norvegicus
<308> P35565
<400> 7298

Met Glu Gly Lys Trp Leu Leu Cys Leu Leu Leu Val Leu Gly Thr Ala 
  1               5                  10                  15
Ala Ile Gln Ala His Asp Gly His Asp Asp Asp Met Ile Asp Ile Glu 
             20                  25                  30
Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Ser Lys 
         35                  40                  45
Ser Asp Thr Ser Thr Pro Pro Ser Pro Lys Val Thr Tyr Lys Ala Pro 
     50                  55                  60
Val Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Ser 
 65                  70                  75                  80
Leu Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp 
                 85                  90                  95
Glu Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Asp Glu Met Lys Glu 
             100                105                110
Thr Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys 
         115                120                125
His His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr 
     130                135                140
Lys Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu 
 145                150                155                160
Cys Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Ser Glu Leu Asn 
                 165                170                175
Leu Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro 
             180                185                190
Asp Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys 
         195                200                205
Asn Pro Lys Thr Gly Val Tyr Glu Glu Lys His Ala Lys Arg Pro Asp 
     210                215                220
Ala Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr 
 225                230                235                240
Leu Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser 
                 245                250                255
Val Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn 
             260                265                270
Pro Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp 
         275                280                285
Asp Glu Arg Pro Lys Ile Ala Asp Pro Asp Ala Val Lys Pro Asp Asp 
     290                295                300
Trp Asp Glu Asp Ala Pro Ser Lys Ile Pro Asp Glu Glu Ala Thr Lys 
 305                310                315                320
Pro Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Ile Pro Asp Pro Asp 
                 325                330                335
Ala Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu 
             340                345                350
Ala Pro Gln Ile Ala Asn Pro Lys Cys Glu Ser Ala Pro Gly Cys Gly 
         355                360                365
Val Trp Gln Arg Pro Met Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp 
     370                375                380
Lys Pro Pro Met Ile Asp Asn Pro Asn Tyr Gln Gly Ile Trp Lys Pro 
 385                390                395                400
Arg Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg 
                 405                410                415
Met Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser 
             420                425                430
Asp Ile Phe Phe Asp Asn Phe Ile Ile Ser Gly Asp Arg Arg Val Val 
         435                440                445
Asp Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly 
     450                455                460
Ala Ala Glu Pro Gly Val Val Gly Gln Met Leu Glu Ala Ala Glu Glu 
 465                470                475                480
Arg Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val 
                 485                490                495
Phe Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Ser Asn Ala 
             500                505                510
Met Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Asp Glu 
         515                520                525
Glu Gly Lys Glu Glu Glu Lys Asn Lys Gly Asp Glu Glu Glu Glu Glu 
     530                535                540
Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly Gly 
 545                550                555                560
Thr Gly Ser Gln Asp Glu Glu Asp Ser Lys Pro Lys Ala Glu Glu Asp 
                 565                570                575
Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
             580                585                590



<210> 7299
<211> 4117
<212> DNA
<213> Homo sapiens
<308> L10284
<400> 7299

tccgcctct  tctttactg  ggcgcgggg  aaggtgtgc  ggcgggaag  ggcacgggc  60
cccccgcgg  ccccgggag  ctagagatc  tggaaggga  gtggttgct  tgtatgtta  120
tggtgcttg  aactgctat  gttgaggct  atgatggac  tgatgatga  gtgattgat  180
ttgaggatg  ccttgacga  gtcattgaa  aggtagaag  ctcaaaacc  gataccact  240
ctcctcctt  atctcccaa  gttacttac  aagctccag  tccaacagg  gaagtatat  300
ttgctgatt  ttttgacag  ggaactctg  cagggtgga  tttatccaa  gccaagaaa  360
acgataccg  tgatgaaat  gccaaatat  atggaaagt  ggaggtaga  gaaatgaag  420
agtcaaagc  tccaggtga  aaaggactt  tgttgatgt  tcgggccaa  catcatgcg  480
tctctgcta  actgaacaa  cccttcctg  ttgacacca  gcctctcat  gttcagtat  540
aggttaatt  ccaaaatgg  atagaatgt  gtggtgcct  tgtgaaact  ctttctaaa  600
caccagaac  caacctgga  cagttccat  acaagaccc  ttatacgat  atgtttggt  660
cagataaat  tggagagga  tataaactg  acttcatct  ccgacacaa  aaccccaaa  720
cgggtatct  tgaagaaaa  catgctaag  ggccagatg  agatctgaa  acctatttt  780
ctgataaga  aacacatct  tacacacta  tcttgaatc  agataatag  tttgaaata  840
tggttgacc  atctgtggt  aatagtgga  atctgctca  tgacatgac  cctcctgta  900
atccttcac  tgaaattga  gacccagaa  accggaagc  cgaggattg  gatgaaaga  960
caaaaatcc  agatccaga  gctgtcaag  cagatgact  ggatgaaga  gcccctgct  1020
agattccag  tgaagaggc  acaaaaccc  aaggctggt  agatgatga  cctgagtac  1080
tacctgatc  agacgcaga  aaacctgag  attgggatg  agacatgga  ggagaatgg  1140
aggctcctc  gattgccaa  cctagatgt  agtcagctc  tggatgtgg  gtctggcag  1200
gacctgtga  tgacaaccc  aattataaa  gcaaatgga  gcctcctat  attgacaat  1260
ccagttacc  gggaatctg  aaacccagg  aaataccaa  tccagattt  tttgaagat  1320
tggaacctt  cagaatgac  ccttttagt  ctattggtt  ggagctgtg  tccatgacc  1380
ctgacattt  ttttgacaa  tttatcatt  gtgctgatc  aagaatagt  gatgattgg  1440
ccaatgatg  atggggcct  aagaaagct  ctgatgggg  tgctgagcc  ggcgttgtg  1500
ggcagatga  cgaggcagc  gaagagcgc  cgtggctgt  ggtagtcta  attctaact  1560
tagcccttc  tgtgttcct  gttatcctc  tctgctgtt  tggaaagaa  cagaccagt  1620
gtatggagt  taagaaaac  gatgcacct  aaccggatg  gaaggaaga  gaagaagag  1680
aggaagagg  aaaggacaa  ggagatgag  aggaggaag  agaagagaa  cttgaagag  1740
aacagaaaa  tgatgctga  gaagatggt  gcactgtca  tcaagagga  gaagacaga  1800
aacctaaag  agaggagga  gaaattttg  acagatcac  aagaaacag  aagccacga  1860
gagagtgaa  caatcttaa  agcttgatc  gtgatttct  ctccctcct  ccctgcaag  1920
gtggtccta  gagaggacc  ggcacacct  aggttgaca  tcagaaaac  tcaagacat  1980
accatcagc  ggctccagt  gaacactag  ctgtgtaac  ttaaacatc  agcagtaaa  2040
acttgcagt  gtgatataa  ggaccctgt  tctgtagaa  agaaaacat  taacataat  2100
gttgtgaaa  gtaacatga  gcaaactaa  ttttttttt  ttaacatct  tgtttttaa  2160
atagaatga  agaactttg  cagtcttta  gatcttggc  taatttaat  tattaatct  2220
tttgtgcaa  cataatacc  ccatttaaa  atgttaggg  gatgagttg  agtttttat  2280
atagatttt  tttaaagtt  ggtattgta  aacattcac  cctctgtcc  tcaaaattg  2340
taattacgt  taaagtgca  tcatttgtg  ttagaatct  gttttgttt  cttccatta  2400
tgagttcct  ctaaggaaa  tgaggagag  gactgaata  aagcccaaa  tcatataaa  2460
gttgcgttt  agttgtatt  aaaatagat  tataagaaa  aattctttc  cttgatgtt  2520
gttagacca  aaagtgtgt  tgttctgta  ctcagttcc  agacagctt  ttaggtagt  2580
gaggaggtg  cttcatgtg  cacttgggc  tttatattc  acttgggag  gtcaggcct  2640
tggcttctg  agcaggtgg  ttgttaagg  acgctagca  ggcatggca  gtgagctcc  2700
gaatagatg  cttcatcac  tcttccact  tgtgttgac  ctgttttcc  tacctattt  2760
ctcagatcc  cagctttct  ctcgctatg  attttcttc  cagtgcagc  tgcagtccg  2820
tgctgaaaa  gattataag  cctgcataa  gttaagctt  attgtgatt  cgtgtatgt  2880
tcttctttc  tttaagcag  cccatacct  tccagggtc  aagtacaga  tagaataca  2940
tgatacaaa  tacagaaaa  tactttgat  tttatccat  tcttttact  tgtgtaaag  3000
ctttagaag  ctaattcac  ggcaaacca  tacagaatt  actgcagtt  aacagacta  3060
aagtatttg  gggaggagt  acatgaagc  tgagttatc  gattttttt  gtagctgct  3120
tatatttta  gccttcatt  gcaattcat  taacagttg  gtcataaat  acacaataa  3180
gcagtcctg  tcaaatttt  ttttaacgt  gcttgtaga  tttttaaaa  agtgatctt  3240
ggtttgttt  ttcatgcgg  atgcagatg  gtgctatca  agcctctcc  acaccacta  3300
agtgtaata  tgttattat  actctacac  gaaacgtat  cagagttag  tattatttt  3360
gcttcagtt  ttctttaga  gctttcaaa  gtaccgatg  tactgtttc  tgcactgaa  3420
atataaaca  tccacagtg  ttatattgg  aagatattg  gaaggaaat  tatttgtaa  3480
agatgaagg  tgtatctat  tttttttct  tttaaactg  ttcacttaa  ttcttttga  3540
gatgggatg  atttttctt  ctgttcagt  ctttttcct  ttcatctgt  gttctgtgg  3600
cacagtgac  ttagctaca  agcagactt  cccaaatgt  ttgattaca  ataaacagt  3660
gttacttag  aagacctga  aatatgtct  caggtttct  cttgaagca  atgtgtggg  3720
tcattgcat  tccagaaat  tgcctcctt  acccaccgt  gacagtata  gtcatgcct  3780
actttcttg  agctgagct  taaatcatt  gagcttaaa  tgtcagatc  ttcattgcc  3840
ttccagggt  atttagtaa  gtttgttga  aacaaaaac  ccttttctt  gttcttttt  3900
cagttattt  gaaggtcca  catcctgat  aaatgtctg  cacttaatg  atgaccagc  3960
gcagctttc  gctcttaaa  agacactta  attttgatt  tacatgctg  ttacctgtt  4020
cattgttgt  aaatgccca  tgtccatca  atgtgttcc  ccattttct  atccacaaa  4080
tactcctca  ttttcaatt  gtcatgtta  taaaccc  4117



<210> 7300
<211> 592
<212> PRT
<213> Homo sapiens
<308> P27824
<400> 7300

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
  1               5                  10                  15
Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
             20                  25                  30
Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
         35                  40                  45
Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
     50                  55                  60
Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
 65                  70                  75                  80
Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                 85                  90                  95
Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
             100                105                110
Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
         115                120                125
His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
     130                135                140
Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
 145                150                155                160
Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu 
                 165                170                175
Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp 
             180                185                190
Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn 
         195                200                205
Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala 
     210                215                220
Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu 
 225                230                235                240
Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val 
                 245                250                255
Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro 
             260                265                270
Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp 
         275                280                285
Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp 
     290                295                300
Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro 
 305                310                315                320
Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala 
                 325                330                335
Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala 
             340                345                350
Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val 
         355                360                365
Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys 
     370                375                380
Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg 
 385                390                395                400
Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met 
                 405                410                415
Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp 
             420                425                430
Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp 
         435                440                445
Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala 
     450                455                460
Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg 
 465                470                475                480
Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe 
                 485                490                495
Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met 
             500                505                510
Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu 
         515                520                525
Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly 
     530                535                540
Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly 
 545                550                555                560
Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu 
                 565                570                575
Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
             580                585                590



<210> 7301
<211> 533
<212> DNA
<213> Rattus norvegicus
<308> AI235747
<400> 7301

gtatttatt  tattttgta  gagtaccct  tagctgttt  cagacacac  agaagagga  60
atcggatcc  attacagat  gttgtgagc  accatgtgg  tgctgggaa  tgaacttag  120
acctctgga  gagcagcca  tgctcttta  cactgagcc  tctcaccag  cccccttcc  180
cagatcaca  ttcaaatac  agttacata  agtattttt  cgtgtttat  atttcaaaa  240
tacctagga  caacaattg  ttctcattt  ttgcaaaac  taaagaaat  ggacagtgc  300
gctccgcta  aacttgaaa  tcttccttg  ttcttcgat  tgttttgca  gcacgggaa  360
ctttctctg  ctgccaggc  gcaggaact  cttcacatt  gggaggctg  tgattctgc  420
cttgaaggc  ttcagcaga  ggaaagagg  cagaaggct  gcatcaaac  cttcaacat  480
gaagagaag  tccagcagg  ggatgttta  ccgggtcag  ctgttacct  caa  533



<210> 7302
<211> 220
<212> PRT
<213> Rattus norvegicus
<308> P04904
<400> 7302

Pro Gly Lys Pro Val Leu His Tyr Phe Asp Gly Arg Gly Arg Met Glu 
  1               5                  10                  15
Pro Ile Arg Trp Leu Leu Ala Ala Ala Gly Val Glu Phe Glu Glu Gln 
             20                  25                  30
Phe Leu Lys Thr Arg Asp Asp Leu Ala Arg Leu Arg Asn Asp Gly Ser 
         35                  40                  45
Leu Met Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys Leu 
     50                  55                  60
Val Gln Thr Arg Ala Ile Leu Asn Tyr Ile Ala Thr Lys Tyr Asn Leu 
 65                  70                  75                  80
Tyr Gly Lys Asp Met Lys Glu Arg Ala Leu Ile Asp Met Tyr Ala Glu 
                 85                  90                  95
Gly Val Ala Asp Leu Asp Glu Ile Val Leu His Tyr Pro Tyr Ile Pro 
             100                105                110
Pro Gly Glu Lys Glu Ala Ser Leu Ala Lys Ile Lys Asp Lys Ala Arg 
         115                120                125
Asn Arg Tyr Phe Pro Ala Phe Glu Lys Val Leu Lys Ser His Gly Gln 
     130                135                140
Asp Tyr Leu Val Gly Asn Arg Leu Ser Arg Ala Asp Val Tyr Leu Val 
 145                150                155                160
Gln Val Leu Tyr His Val Glu Glu Leu Asp Pro Ser Ala Leu Ala Asn 
                 165                170                175
Phe Pro Leu Leu Lys Ala Leu Arg Thr Arg Val Ser Asn Leu Pro Thr 
             180                185                190
Val Lys Lys Phe Leu Gln Pro Gly Ser Gln Arg Lys Pro Leu Glu Asp 
         195                200                205
Glu Lys Cys Val Glu Ser Ala Val Lys Ile Phe Ser 
     210                215                220



<210> 7303
<211> 918
<212> DNA
<213> Homo sapiens
<308> NM_000847
<400> 7303

ggtggcctt  agaagctga  cggagaccg  ctagacttt  ctcaaagaa  ccaagagac  60
gttaccatg  cagggaagc  caagcttca  tacttcaat  gacggggca  aatggagcc  120
atccggtgg  tcttggctg  agctggagt  gagtttgaa  agaaattta  aggatctgc  180
gaagatttg  gaaagttaa  aaatgatgg  agtttgatg  tccagcaag  accaatggt  240
gagattgat  ggattaagt  ggtacagac  agagccatt  tcaactaca  tgccagcaa  300
tacaacctc  acgggaaag  cataaagga  agagcccta  ttgatatgt  tacagaagg  360
atggcagat  tgaatgaaa  gatccttct  ctgccctta  gtcgacctg  ggaaaaaga  420
gccaagatt  ccttgatca  agagaaaac  aaaagtcgc  atttccctg  cttcgaaaa  480
gtgttacag  gccatggac  agactacct  gttggcaac  agctgagcc  ggctgacat  540
agcctggtg  aacttctct  ctatgtgga  gagcttgac  ccagcctta  ctccaactt  600
cctctgctg  aggccctga  aaccagaat  agcaacctg  ccacggtga  gaagtttct  660
cagcctggc  gcccaagga  gcctcccgc  gatgcaaaa  ctttagaag  agccagaaa  720
attttcagg  tttaataaa  cagccatgg  ggctaagaa  atgcaagac  aatattcta  780
agttttgca  caatgaagt  ctttactta  gtgttgatt  tgcctgttg  aaagctaat  840
aaccctttc  aattatatg  taattaaat  ataaaaact  ctatttgca  aaaaaaaaa  900
aaaaaaaaa  aaaaaaaa  918



<210> 7304
<211> 222
<212> PRT
<213> Homo sapiens
<308> Q16772
<400> 7304

Met Ala Gly Lys Pro Lys Leu His Tyr Phe Asn Gly Arg Gly Arg Met 
  1               5                  10                  15
Glu Pro Ile Arg Trp Leu Leu Ala Ala Ala Gly Val Glu Phe Glu Glu 
             20                  25                  30
Lys Phe Ile Gly Ser Ala Glu Asp Leu Gly Lys Leu Arg Asn Asp Gly 
         35                  40                  45
Ser Leu Met Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys 
     50                  55                  60
Leu Val Gln Thr Arg Ala Ile Leu Asn Tyr Ile Ala Ser Lys Tyr Asn 
 65                  70                  75                  80
Leu Tyr Gly Lys Asp Ile Lys Glu Arg Ala Leu Ile Asp Met Tyr Thr 
                 85                  90                  95
Glu Gly Met Ala Asp Leu Asn Glu Met Ile Leu Leu Leu Pro Leu Cys 
             100                105                110
Arg Pro Glu Glu Lys Asp Ala Lys Ile Ala Leu Ile Lys Glu Lys Thr 
         115                120                125
Lys Ser Arg Tyr Phe Pro Ala Phe Glu Lys Val Leu Gln Ser His Gly 
     130                135                140
Gln Asp Tyr Leu Val Gly Asn Lys Leu Ser Arg Ala Asp Ile Ser Leu 
 145                150                155                160
Val Glu Leu Leu Tyr Tyr Val Glu Glu Leu Asp Ser Ser Leu Ile Ser 
                 165                170                175
Asn Phe Pro Leu Leu Lys Ala Leu Lys Thr Arg Ile Ser Asn Leu Pro 
             180                185                190
Thr Val Lys Lys Phe Leu Gln Pro Gly Ser Pro Arg Lys Pro Pro Ala 
         195                200                205
Asp Ala Lys Ala Leu Glu Glu Ala Arg Lys Ile Phe Arg Phe 
     210                215                220



<210> 7305
<211> 413
<212> DNA
<213> Rattus norvegicus
<308> AI237258
<400> 7305

ggtgtccta  atcatggct  gtttattaa  atattggtg  aaaaatagg  gtctctagg  60
ctgctgaca  gaggggaca  catagcact  aaggtgtct  gactctcct  ctcctcctc  120
ccacccagt  cattcccag  ttgcaacac  tccatcagc  gttgtcgga  gcctgggtc  180
acatcctta  cacggtcct  ctcttcact  tcttcccca  cctcactat  cacgtcact  240
tctgagttc  tactgtcct  actgtctga  tctgcgtcc  ctccatgtt  cagctgctt  300
tcgtcagtg  cagtgacca  cacgttgtc  tcctcatcc  catttgtct  agggttgag  360
acagccagg  ttagctgta  cccacgtgg  gtcaggtgg  aacagacat  acc  413



<210> 7306
<211> 1277
<212> PRT
<213> Rattus norvegicus
<308> NP_113856
<400> 7306

Met Lys Tyr Ala Leu Lys Arg Leu Ile Thr Gly Leu Gly Val Gly Arg 
  1               5                  10                  15
Glu Ala Ala Arg Pro Cys Tyr Ser Leu Ala Leu Ala Gln Leu Leu Gln 
             20                  25                  30
Ser Phe Glu Asp Ile Gln Leu Cys Asp Ile Leu Gly Gln Ile Gln Glu 
         35                  40                  45
Lys Tyr Asn Leu Gln Ala Met Asn Lys Ala Met Met Arg Pro Thr Leu 
     50                  55                  60
Phe Ala Asn Leu Phe Ala Val Leu Ala Leu Phe Gln Ser Gly Arg Leu 
 65                  70                  75                  80
Val Lys Asp Lys Glu Ala Leu Met Lys Cys Val Arg Leu Leu Lys Ile 
                 85                  90                  95
Leu Ser His His Tyr Asn His Leu Gln Gly Gln Pro Val Lys Ala Leu 
             100                105                110
Val Asp Ile Leu Ser Glu Val Pro Glu Ser Met Phe Gln Glu Ile Leu 
         115                120                125
Pro Lys Val Leu Lys Gly Asp Met Lys Val Ile Leu Ser Ser Pro Lys 
     130                135                140
Tyr Leu Glu Leu Phe Leu Leu Ala Arg Gln Arg Val Pro Ala Glu Leu 
 145                150                155                160
Glu Ser Leu Val Gly Ser Val Asp Leu Phe Ser Glu Asp Asn Ile Pro 
                 165                170                175
Ser Leu Val Asn Ile Leu Lys Val Ala Ala Asn Ser Val Lys Lys Glu 
             180                185                190
Gln Lys Leu Pro Asp Val Ala Leu Asn Leu Leu Arg Leu Ala Leu Gln 
         195                200                205
Glu Asn Lys Phe Glu Arg Phe Trp Lys Glu Val Leu Glu Glu Gly Leu 
     210                215                220
Leu Lys Lys Pro Ser Tyr Thr Ser Ser Tyr Met Cys Phe Arg Leu Leu 
 225                230                235                240
Gly Ala Ser Leu Pro Leu Leu Ser Asp Glu Gln Leu Gln Leu Val Met 
                 245                250                255
Arg Gly Asp Leu Ile Arg His Phe Gly Glu His Met Val Val Ser Lys 
             260                265                270
Ser Gln Asn Pro Leu Arg Phe Ile Pro Glu Ile Ser Ala Tyr Val Gly 
         275                280                285
Thr Phe Leu Glu Gly Cys Gln Asp Asp Pro Lys Arg Gln Phe Thr Val 
     290                295                300
Met Val Ala Phe Thr Ala Ile Thr Asn Gln Gly Leu Pro Val Met Pro 
 305                310                315                320
Thr Phe Trp Arg Val Thr Arg Phe Leu Asn Thr Glu Ala Leu Gln Asn 
                 325                330                335
Tyr Val Thr Trp Leu Arg Asp Met Phe Leu Gln Pro Asp Leu Asp Ser 
             340                345                350
Leu Val Asp Phe Ser Thr Ala Asn Gln Lys Arg Val Gln Asp Ala Ser 
         355                360                365
Leu Asn Val Pro Glu Arg Thr Val Phe Arg Leu Arg Lys Trp Ile Ile 
     370                375                380
His Arg Leu Val Ser Leu Val Asp His Leu His Leu Glu Lys Asp Glu 
 385                390                395                400
Ala Val Val Glu Gln Ile Ala Arg Phe Cys Leu Phe His Ala Phe Phe 
                 405                410                415
Lys Thr Lys Lys Ala Thr Pro Gln Ile Pro Glu Thr Lys Gln His Phe 
             420                425                430
Ser Phe Pro Leu Glu Asp Gly Asn Arg Gly Val Ile Val Ser Ala Phe 
         435                440                445
Phe Ser Leu Leu Gln Thr Leu Ser Val Lys Phe Arg Gln Thr Pro Asp 
     450                455                460
Leu Ala Glu Asn Gly Lys Pro Trp Thr Tyr Arg Leu Val Gln Leu Ala 
 465                470                475                480
Asp Met Leu Leu Lys His Asn Arg Asn Val Ala Asn Val Thr Pro Leu 
                 485                490                495
Thr Ala Gln Gln Arg Gln Ala Trp Asp Gln Met Met Ser Thr Leu Lys 
             500                505                510
Glu Leu Glu Ala Gln Ser Ser Glu Thr Arg Ala Ile Ala Phe Gln His 
         515                520                525
Leu Leu Leu Leu Val Gly Leu His Leu Phe Lys Ser Pro Ala Glu Ser 
     530                535                540
Cys Asp Val Leu Gly Asp Ile Gln Thr Cys Ile Lys Lys Ser Met Glu 
 545                550                555                560
Gln Asn Leu Arg Arg Ser Arg Ser Arg Ala Lys Ala Ser Gln Glu Pro 
                 565                570                575
Val Trp Val Glu Val Met Val Glu Ile Leu Leu Ser Leu Leu Ala Gln 
             580                585                590
Pro Ser Asn Leu Met Arg Gln Val Val Arg Ser Val Phe Gly His Val 
         595                600                605
Cys Ser His Leu Thr Pro Arg Gly Leu Gln Leu Ile Leu Ala Val Leu 
     610                615                620
Asn Pro Glu Thr Asn Glu Asp Glu Glu Asp Asn Val Val Val Thr Asp 
 625                630                635                640
Thr Asp Glu Lys Gln Leu Lys His Gly Glu Asp Ala Asp Ser Asp Ser 
                 645                650                655
Glu Asp Ser Lys Asn Ser Glu Ser Asp Val Asp Ser Glu Asp Gly Glu 
             660                665                670
Glu Ser Glu Glu Glu Asp Arg Asp Lys Asp Val Asp Pro Gly Phe Arg 
         675                680                685
Gln Gln Leu Met Glu Val Leu Gln Ala Gly Asn Ala Leu Gly Gly Glu 
     690                695                700
Glu Glu Glu Glu Glu Glu Leu Gly Asp Glu Ala Met Met Ala Leu Asp 
 705                710                715                720
Gln Asn Leu Ala Ser Leu Phe Ala Glu Gln Lys Met Arg Ile Gln Ala 
                 725                730                735
Arg His Glu Glu Lys Asn Lys Leu Gln Lys Glu Lys Gln Leu Arg Arg 
             740                745                750
Asp Phe Gln Ile Arg Ala Leu Asp Leu Ile Glu Val Leu Val Thr Lys 
         755                760                765
Gln Pro Glu His Pro Leu Ile Leu Glu Leu Leu Glu Pro Leu Leu Asn 
     770                775                780
Ile Ile Gln Arg Ser Met Arg Ser Arg Gly Ser Thr Lys Gln Glu Gln 
 785                790                795                800
Asp Leu Leu His Lys Thr Ala Arg Ile Phe Met His His Leu Cys Arg 
                 805                810                815
Ala Arg His Tyr Cys His Glu Val Glu Pro Gly Ala Glu Ala Leu His 
             820                825                830
Ala Gln Val Glu Arg Phe Val Gln Gln Ala Gly Asn Gln Ala Asp Ala 
         835                840                845
Ser Val Ala Leu Tyr Tyr Phe Asn Ala Ser Leu Tyr Leu Leu Arg Val 
     850                855                860
Leu Lys Gly Asn Thr Thr Lys Arg Tyr Gln Asp Gly Gln Lys Leu Glu 
 865                870                875                880
Gly Ala Asp Ile Lys Ser Glu Pro Lys Asp Ser Glu Val Gln Thr Thr 
                 885                890                895
Ser Cys Leu Asp Leu Asp Phe Val Thr Arg Val Tyr Ser Ala Ser Leu 
             900                905                910
Glu Ser Leu Leu Thr Lys Arg Asn Ser Pro Leu Thr Ile Pro Met Phe 
         915                920                925
Leu Asp Leu Phe Ser Arg Tyr Pro Val Ile Cys Lys Asn Leu Leu Pro 
     930                935                940
Ile Val Val Gln His Val Ala Gly Ser Ser Arg Pro Arg His Gln Ala 
 945                950                955                960
Gln Ala Cys Leu Leu Leu Gln Lys Ala Leu Ser Ala Arg Glu Leu Arg 
                 965                970                975
Val Cys Phe Glu Asp Pro Glu Trp Glu Gln Leu Ile Ser Gln Val Leu 
             980                985                990
Gly Lys Thr Thr Gln Thr Leu Gln Thr Leu Gly Glu Ala Gln Ser Lys 
         995                1000                1005
Gly Glu His Gln Arg Glu Leu Ser Ile Leu Glu Leu Leu Asn Thr Val 
     1010                1015                1020
Phe Arg Ile Val Asn His Glu Lys Leu Ser Val Asp Leu Thr Ala Phe 
 1025                1030                1035                1040
Leu Gly Met Leu Gln Gly Lys Gln Gln Lys Leu Gln Gln Asn Leu Gln 
                 1045                1050                1055
Gln Gly Asn His Ser Ser Gly Ser Ser Arg Leu Tyr Asp Leu Tyr Trp 
             1060                1065                1070
Gln Ala Met Asn Leu Leu Gly Val Gln Arg Pro Lys Ser Glu Lys Lys 
         1075                1080                1085
Asn Val Lys Asp Ile Pro Ser Asp Ser Gln Ser Pro Ile Ser Thr Lys 
     1090                1095                1100
Arg Lys Lys Lys Gly Phe Leu Pro Glu Thr Lys Lys Arg Lys Lys Leu 
 1105                1110                1115                1120
Lys Ser Glu Gly Thr Thr Ser Glu Lys Lys Ala Ala Ser Gln Gln Asp 
                 1125                1130                1135
Arg Val Thr Glu Gly Ala Met Pro Ala Ala Thr Gly Lys Asp Gln Pro 
             1140                1145                1150
Pro Ser Thr Gly Lys Lys Arg Arg Lys Arg Val Lys Ala Asn Thr Pro 
         1155                1160                1165
Ser Gln Val Asn Gly Val Thr Val Ala Lys Ser Pro Ala Pro Asn Asn 
     1170                1175                1180
Pro Thr Leu Ser Pro Ser Thr Pro Pro Ala Lys Thr Pro Lys Val Gln 
 1185                1190                1195                1200
Lys Lys Lys Glu Lys Leu Ser Gln Val Asn Gly Ser Thr Pro Val Ser 
                 1205                1210                1215
Pro Val Glu Pro Glu Ser Lys Lys His Gln Lys Ala Leu Ser Thr Lys 
             1220                1225                1230
Glu Val Lys Arg Arg Ser Ser Gln Ser Ala Leu Pro Lys Lys Arg Ala 
         1235                1240                1245
Arg Leu Ser Leu Val Ser Arg Ser Pro Ser Leu Leu Gln Ser Gly Ile 
     1250                1255                1260
Arg Lys Arg Arg Val Ala Arg Arg Arg Val Gln Thr Pro 
 1265                1270                1275



<210> 7307
<211> 689
<212> DNA
<213> Rattus norvegicus
<308> AI237654
<400> 7307

tttttttgt  aagatataa  aagggaaca  tgattttaa  aaacaaaaa  actcctcgc  60
ttcaaaata  tggccatga  ttctctttt  ctagtatgt  acattggct  tgttgcccc  120
tggcacaga  gttcatggt  tgttctttt  attcccttc  aaacaaaac  ccttggaaa  180
accatgcct  aaggtcact  agaccccga  tcaaaaaaa  taacaactt  ttcatttcc  240
acatctggg  aagtgggcc  ggtctgaat  ttttgagcg  tccgacatt  acccagcaa  300
cactcctat  tcacggtgc  ggcactggt  tgcacccct  gaggctgga  acttgccta  360
tgattgcca  ccatctgtg  agtcagagg  gggggtgta  ccactcccc  ctggagaga  420
tgagtctct  aaacattgg  gttcaagca  agaggcaga  agcgttgag  agtacagat  480
agtcgtccc  gaaggctca  tgcacgttg  tgttgttgt  gttaaggac  cagggatcc  540
cctcagtgt  agtgggcgg  ggcatgaac  ggaactcgg  ggcgtacat  aagataggg  600
tgtcttgag  atcatccac  tcatctagc  ggggggtgg  ggggctctc  aatctgtga  660
cttcaggaa  cacgtccat  taacaaggt  689



<210> 7308
<211> 581
<212> DNA
<213> Homo sapiens
<308> AW601963
<400> 7308

gttcaggat  ctaataaac  ctgggggta  cggcaatca  ctgcatttt  accacatac  60
cttgaataa  ccaaaatac  gagagttgc  tccctatgc  caacatcca  aggaccaaa  120
ttggaaagg  gaactgtag  tggcttata  gctggcctt  ggtgctctt  tgacctgtg  180
atagccata  ttagctcac  ggctaagag  ctgaaaaga  tctaccacc  tcaggcgtg  240
ggggaacat  aacaggagg  tgacaaaca  ggagggaag  ttctattgt  cctggtgag  300
gaattgaca  aaaaggatt  tgtgaaggt  atgagattt  catccatgc  gactttgag  360
atacatgtt  ccgaattgt  gtccccaaa  ctgccattg  ggcccgcca  acttacctt  420
ccaatggcc  gaccaaggt  ctgactcag  agttgtcat  agtcagagg  aatcatatt  480
tctcaggga  atgcgcatc  tggcgtggc  agagccttc  ggttcagaa  atcaggcct  540
ctatcctgg  tgcaacatc  ttcgagttg  atattcctt  t  581



<210> 7309
<211> 391
<212> PRT
<213> Homo sapiens
<308> XP_002093
<400> 7309

Met Val Met Phe Lys Lys Ile Lys Ser Phe Glu Val Val Phe Asn Asp 
  1               5                  10                  15
Pro Glu Lys Val Tyr Gly Ser Gly Glu Lys Val Ala Gly Arg Val Ile 
             20                  25                  30
Val Glu Val Cys Glu Val Thr Arg Val Lys Ala Val Arg Ile Leu Ala 
         35                  40                  45
Cys Gly Val Ala Lys Val Leu Trp Met Gln Gly Ser Gln Gln Cys Lys 
     50                  55                  60
Gln Thr Ser Glu Tyr Leu Arg Tyr Glu Asp Thr Leu Leu Leu Glu Asp 
 65                  70                  75                  80
Gln Pro Thr Gly Glu Asn Glu Met Val Ile Met Arg Pro Gly Asn Lys 
                 85                  90                  95
Tyr Glu Tyr Lys Phe Gly Phe Glu Leu Pro Gln Gly Pro Leu Gly Thr 
             100                105                110
Ser Phe Lys Gly Lys Tyr Gly Cys Val Asp Tyr Trp Val Lys Ala Phe 
         115                120                125
Leu Asp Arg Pro Ser Gln Pro Thr Gln Glu Thr Lys Lys Asn Phe Glu 
     130                135                140
Val Val Asp Leu Val Asp Val Asn Thr Pro Asp Leu Met Ala Pro Val 
 145                150                155                160
Ser Ala Lys Lys Glu Lys Lys Val Ser Cys Met Phe Ile Pro Asp Gly 
                 165                170                175
Arg Val Ser Val Ser Ala Arg Ile Asp Arg Lys Gly Phe Cys Glu Gly 
             180                185                190
Asp Glu Ile Ser Ile His Ala Asp Phe Glu Asn Thr Cys Ser Arg Ile 
         195                200                205
Val Val Pro Lys Ala Ala Ile Val Ala Arg His Thr Tyr Leu Ala Asn 
     210                215                220
Gly Gln Thr Lys Val Leu Thr Gln Lys Leu Ser Ser Val Arg Gly Asn 
 225                230                235                240
His Ile Ile Ser Gly Thr Cys Ala Ser Trp Arg Gly Lys Ser Leu Arg 
                 245                250                255
Val Gln Lys Ile Arg Pro Ser Ile Leu Gly Cys Asn Ile Leu Arg Val 
             260                265                270
Glu Tyr Ser Leu Leu Ile Tyr Val Ser Val Pro Gly Ser Lys Lys Val 
         275                280                285
Ile Leu Asp Leu Pro Leu Val Ile Gly Ser Arg Ser Gly Leu Ser Ser 
     290                295                300
Arg Thr Ser Ser Met Ala Ser Arg Thr Ser Ser Glu Met Ser Trp Val 
 305                310                315                320
Asp Leu Asn Ile Pro Asp Thr Pro Glu Ala Pro Pro Cys Tyr Met Asp 
                 325                330                335
Val Ile Pro Glu Asp His Arg Leu Glu Ser Pro Thr Thr Pro Leu Leu 
             340                345                350
Asp Asp Met Asp Gly Ser Gln Asp Ser Pro Ile Phe Met Tyr Ala Pro 
         355                360                365
Glu Phe Lys Phe Met Pro Pro Pro Thr Tyr Thr Glu Val Asp Pro Cys 
     370                375                380
Ile Leu Asn Asn Asn Val Gln 
 385                390



<210> 7310
<211> 558
<212> DNA
<213> Rattus norvegicus
<308> AI638939
<400> 7310

ttntnnnnn  naatctttt  tggtttgtt  agtgcagtg  ggtcctcaa  aatcatgat  60
ccgtgaggg  ggcacatgt  gtcctttct  ctggggaca  cactaatta  tatcttgct  120
ctggcagag  aagaaaaat  agggaagtg  ctgtatttc  gatcgtcgt  tgactcctt  180
ctactgtct  tggggtctt  cactttgat  gccattacg  tatccgact  tagctgttc  240
atgtctctt  agtccttgg  ctctctgat  ttgcccttt  ctgacttcc  gaattctgc  300
tccgcctgg  acgcagttt  aatggtttt  tccattttc  tgtctcgct  ttccttccc  360
ttttccatc  cctcgattc  tcctccgtc  gagtctttg  acttggtta  ctctgtgcc  420
tccattttt  cgccctctg  cgccaggca  atctctgcc  gttgaaaga  tgcagaatt  480
ccacagcgt  tcacaggct  agtgccacc  aactgcgaa  tgcttgaag  gatctcttg  540
aactgaaac  aagctgat  558



<210> 7311
<211> 523
<212> DNA
<213> Rattus norvegicus
<308> AI638955
<400> 7311

ttaaccaca  ttttaaaaa  aagcaaaaa  aagaacaaa  aaccccaaa  caaaaaaca  60
aacaaaaaa  ccccaaaac  accccccct  caaacaaaa  caaaaattc  aaaacaaaa  120
caaaaccaa  aaaagcaca  tctttggaa  aaaagaatt  aaggcagaa  tttaaagga  180
aaatacata  tcaaagaac  cagtgaggt  taaaaagta  tctctcttt  ttgtttgtt  240
tcctcttca  cttgctata  agtcctcta  tagtaaata  tgcaatagc  aggcctcat  300
aactggggg  tgtcccatt  gcaggggtc  cacgtcact  cagtagggg  caaatcggc  360
gtagccacc  cggtacaaa  tcgccacag  gccaactcc  tagctggcg  caggggcga  420
ggcatggta  gggtcagct  tgtacaccc  gccgtaacc  tcgctgtaa  cggctgcag  480
ggctgcagc  gctgtggct  cggttgcag  aacaggctg  gca  523



<210> 7312
<211> 377
<212> PRT
<213> Rattus norvegicus
<308> AAK64287
<400> 7312

Met Glu Lys Lys Lys Met Val Thr Gln Gly Asn Gln Glu Pro Thr Thr 
  1               5                  10                  15
Thr Pro Asp Ala Met Val Gln Pro Phe Thr Thr Ile Pro Phe Pro Pro 
             20                  25                  30
Pro Pro Gln Asn Gly Ile Pro Thr Glu Tyr Gly Val Pro His Thr Gln 
         35                  40                  45
Asp Tyr Ala Gly Gln Thr Ser Glu His Asn Leu Thr Leu Tyr Gly Ser 
     50                  55                  60
Thr Gln Pro His Gly Glu Gln Ser Ser Asn Ser Pro Ser Asn Gln Asn 
 65                  70                  75                  80
Gly Ser Leu Thr Gln Thr Glu Gly Gly Ala Gln Thr Asp Gly Gln Gln 
                 85                  90                  95
Ser Gln Thr Gln Ser Ser Glu Asn Ser Glu Ser Lys Ser Thr Pro Lys 
             100                105                110
Arg Leu His Val Ser Asn Ile Pro Phe Arg Phe Arg Asp Pro Asp Leu 
         115                120                125
Arg Gln Met Phe Gly Gln Phe Gly Lys Ile Leu Asp Val Glu Ile Ile 
     130                135                140
Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe Val Thr Phe Glu Asn 
 145                150                155                160
Ser Ala Asp Ala Asp Arg Ala Arg Glu Lys Leu His Gly Thr Val Val 
                 165                170                175
Glu Gly Arg Lys Ile Glu Val Asn Asn Ala Thr Ala Arg Val Met Thr 
             180                185                190
Asn Lys Lys Met Val Thr Pro Tyr Ala Asn Gly Trp Lys Leu Ser Pro 
         195                200                205
Val Val Gly Ala Val Tyr Gly Pro Glu Leu Tyr Ala Ala Ser Ser Phe 
     210                215                220
Gln Ala Asp Val Ser Leu Gly Asn Glu Ala Ala Val Pro Leu Ser Gly 
 225                230                235                240
Arg Gly Gly Ile Asn Thr Tyr Ile Pro Leu Ile Ile Pro Gly Phe Pro 
                 245                250                255
Tyr Pro Thr Ala Ala Thr Thr Ala Ala Ala Phe Arg Gly Ala His Leu 
             260                265                270
Arg Gly Arg Gly Arg Thr Val Tyr Gly Ala Val Arg Ala Val Pro Pro 
         275                280                285
Thr Ala Ile Pro Ala Tyr Pro Gly Val Val Tyr Gln Asp Gly Phe Tyr 
     290                295                300
Gly Ala Asp Leu Tyr Gly Gly Tyr Ala Ala Tyr Arg Tyr Ala Gln Pro 
 305                310                315                320
Ala Thr Ala Thr Ala Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Tyr 
                 325                330                335
Ser Asp Gly Tyr Gly Arg Val Tyr Thr Ala Asp Pro Tyr His Ala Leu 
             340                345                350
Ala Pro Ala Ala Ser Tyr Gly Val Gly Ala Val Ala Ser Leu Tyr Arg 
         355                360                365
Gly Gly Tyr Ser Arg Phe Ala Pro Tyr 
     370                375



<210> 7313
<211> 1876
<212> DNA
<213> Homo sapiens
<308> AL009266
<400> 7313

ctctaaaga  gaaacatta  aaagaaaaa  gaaggaaaa  ggtataaag  gagatcaat  60
acccaccct  aaatagcta  attgggggg  gaggggggt  gaaaagaaa  ctgtggagg  120
gtgccccag  acggctgct  tgaaaggtt  atcatctat  cgtttggtt  atggagaaa  180
agaaaatgg  aactcaggg  aaccaggag  cgacaacaa  tcctgacgc  atggttcag  240
cttttacta  catcccatt  ccaccacct  cgcagaatg  aattcccac  gagtatggg  300
tgccacaca  tcaagacta  gccggccag  ccggtgagc  taacctgac  ctctacgga  360
gtacgcaag  ccacgggga  cagagcagc  actcaccca  cacacaaaa  ggatctctt  420
cgcagacag  aggtggagc  cagacagac  gccagcagt  acagacaca  agtagtgaa  480
attcagaga  taaatctac  ccgaaacgg  tgcatgtct  taatattcc  ttccgcttc  540
gggaccctg  cctccggca  atgtttggg  agtttggca  aatcctaga  gtagaaata  600
tctttaatg  acgtggctc  aagggattc  ggttcgtaa  tttcgagaa  agtgctgat  660
cagacaggg  cagggagaa  ttacacggc  ccgtggtag  gggccgtaa  atcgaggtg  720
ataatgcta  agcacgtgt  atgaccaat  agaagatgg  cacaccata  gcaaatggt  780
ggaaattaa  cccagtagt  ggagctgta  atggtccgg  gttatatgc  gcatccagc  840
ttcaagcag  tgtgtccct  ggcaatgat  cagcagtgc  cctatcagg  agagggggt  900
tcaacactt  cattccttt  atcattcct  gcttccctt  ccctactgc  gccaccacg  960
cagccgctt  cagaggagc  catttgagg  gcagagggc  gacagtata  ggtgcagtc  1020
gagcggtac  tccaacagc  atccccgcc  atccagggg  ggatatgca  cctacagat  1080
tgcacagcc  gctactgca  ccgcagcca  cgctgctgc  gccgctgca  ccgcttaca  1140
tgacggtta  ggcagggtg  acacagccg  cccctacca  gcccttgcc  ctgccgcta  1200
ctatggagt  ggcgctgtg  cgagtttat  ccgaggtgg  tacagccga  ttgccccct  1260
ctgaagtga  gtgagaccc  tgcaaatgg  acagccccc  agttcatga  gcctggcta  1320
tgcaatatt  actagtaga  gaactctat  gcaagatga  gaggaaaaa  aaacaaaca  1380
acaaaaaaa  acacaaaaa  agaaagaat  cttttttat  cctcactat  ttctttgaa  1440
atgtatttt  cctttaaat  tctgccttt  attcttttg  tccaaagat  gtgcatttt  1500
ttctttttt  ttttaaact  tggtaaaaa  aaaaaaaaa  aatgcattt  catgtctgt  1560
tgtccgtgc  tagcttatt  tatcaatca  ggaagaggc  gtcaaggag  aaggagaga  1620
attaggagc  gataaatgc  tctgatcag  aatcagcag  cagaattac  aaagtgtat  1680
tggtgctga  tgactgggg  acaagcaga  gtggaagag  tctttctgc  acaggatat  1740
cttctagtc  tctgagttt  tggtctttg  caggcaatt  tggttggct  tggctggaa  1800
ccacatgct  atagatagg  atttgtgct  acaaagcag  agaattaaa  agacgcttt  1860
ctctcctcc  ttagag  1876



<210> 7314
<211> 391
<212> PRT
<213> Homo sapiens
<308> O43251
<400> 7314

Met Glu Lys Lys Lys Met Val Thr Gln Gly Asn Gln Glu Pro Thr Thr 
  1               5                  10                  15
Thr Pro Asp Ala Met Val Gln Pro Phe Thr Thr Ile Pro Phe Pro Pro 
             20                  25                  30
Pro Pro Gln Asn Gly Ile Pro Thr Glu Tyr Gly Val Pro His Thr Gln 
         35                  40                  45
Asp Tyr Ala Gly Gln Thr Gly Glu His Asn Leu Thr Leu Tyr Gly Ser 
     50                  55                  60
Thr Gln Ala His Gly Glu Gln Ser Ser Asn Ser Pro Ser Thr Gln Asn 
 65                  70                  75                  80
Gly Ser Leu Thr Gln Thr Glu Gly Gly Ala Gln Thr Asp Gly Gln Gln 
                 85                  90                  95
Ser Gln Thr Gln Ser Ser Glu Asn Ser Glu Ser Lys Ser Thr Pro Lys 
             100                105                110
Arg Leu His Val Ser Asn Ile Pro Phe Arg Phe Arg Asp Pro Asp Leu 
         115                120                125
Arg Gln Met Phe Gly Gln Phe Gly Lys Ile Leu Asp Val Glu Ile Ile 
     130                135                140
Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe Val Thr Phe Glu Asn 
 145                150                155                160
Ser Ala Asp Ala Asp Arg Ala Arg Glu Lys Leu His Gly Thr Val Val 
                 165                170                175
Glu Gly Arg Lys Ile Glu Val Asn Asn Ala Thr Ala Arg Val Met Thr 
             180                185                190
Asn Lys Lys Met Val Thr Pro Tyr Ala Asn Gly Trp Lys Leu Ser Pro 
         195                200                205
Val Val Gly Ala Val Tyr Gly Pro Glu Leu Tyr Ala Ala Ser Ser Phe 
     210                215                220
Gln Ala Asp Val Ser Leu Gly Asn Asp Ala Ala Val Pro Leu Ser Gly 
 225                230                235                240
Arg Gly Gly Ile Asn Thr Tyr Ile Pro Leu Ile Ile Pro Gly Phe Pro 
                 245                250                255
Tyr Pro Thr Ala Ala Thr Thr Ala Ala Ala Phe Arg Gly Ala His Leu 
             260                265                270
Arg Gly Arg Gly Arg Thr Val Tyr Gly Ala Val Arg Ala Val Pro Pro 
         275                280                285
Thr Ala Ile Pro Ala Tyr Pro Gly Val Val Tyr Gln Asp Gly Phe Tyr 
     290                295                300
Gly Ala Asp Leu Tyr Ile Glu Ser Ala Asn Cys Phe Arg Ser Asn Arg 
 305                310                315                320
Val Asp Met Gln Pro Thr Asp Met His Ser Leu Leu Leu Gln Pro Gln 
                 325                330                335
Pro Pro Leu Leu Gln Pro Leu Gln Pro Leu Thr Val Thr Val Met Ala 
             340                345                350
Gly Cys Thr Gln Pro Thr Pro Thr Met Pro Leu Pro Leu Pro Leu Ala 
         355                360                365
Met Glu Leu Ala Leu Trp Arg Val Tyr Thr Glu Val Ala Thr Ala Asp 
     370                375                380
Leu Pro Pro Thr Glu Val Thr 
 385                390



<210> 7315
<211> 523
<212> DNA
<213> Rattus norvegicus
<308> AI638955
<400> 7315

ttaaccaca  ttttaaaaa  aagcaaaaa  aagaacaaa  aaccccaaa  caaaaaaca  60
aacaaaaaa  ccccaaaac  accccccct  caaacaaaa  caaaaattc  aaaacaaaa  120
caaaaccaa  aaaagcaca  tctttggaa  aaaagaatt  aaggcagaa  tttaaagga  180
aaatacata  tcaaagaac  cagtgaggt  taaaaagta  tctctcttt  ttgtttgtt  240
tcctcttca  cttgctata  agtcctcta  tagtaaata  tgcaatagc  aggcctcat  300
aactggggg  tgtcccatt  gcaggggtc  cacgtcact  cagtagggg  caaatcggc  360
gtagccacc  cggtacaaa  tcgccacag  gccaactcc  tagctggcg  caggggcga  420
ggcatggta  gggtcagct  tgtacaccc  gccgtaacc  tcgctgtaa  cggctgcag  480
ggctgcagc  gctgtggct  cggttgcag  aacaggctg  gca  523



<210> 7316
<211> 377
<212> PRT
<213> Rattus norvegicus
<308> AAK64287
<400> 7316

Met Glu Lys Lys Lys Met Val Thr Gln Gly Asn Gln Glu Pro Thr Thr 
  1               5                  10                  15
Thr Pro Asp Ala Met Val Gln Pro Phe Thr Thr Ile Pro Phe Pro Pro 
             20                  25                  30
Pro Pro Gln Asn Gly Ile Pro Thr Glu Tyr Gly Val Pro His Thr Gln 
         35                  40                  45
Asp Tyr Ala Gly Gln Thr Ser Glu His Asn Leu Thr Leu Tyr Gly Ser 
     50                  55                  60
Thr Gln Pro His Gly Glu Gln Ser Ser Asn Ser Pro Ser Asn Gln Asn 
 65                  70                  75                  80
Gly Ser Leu Thr Gln Thr Glu Gly Gly Ala Gln Thr Asp Gly Gln Gln 
                 85                  90                  95
Ser Gln Thr Gln Ser Ser Glu Asn Ser Glu Ser Lys Ser Thr Pro Lys 
             100                105                110
Arg Leu His Val Ser Asn Ile Pro Phe Arg Phe Arg Asp Pro Asp Leu 
         115                120                125
Arg Gln Met Phe Gly Gln Phe Gly Lys Ile Leu Asp Val Glu Ile Ile 
     130                135                140
Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe Val Thr Phe Glu Asn 
 145                150                155                160
Ser Ala Asp Ala Asp Arg Ala Arg Glu Lys Leu His Gly Thr Val Val 
                 165                170                175
Glu Gly Arg Lys Ile Glu Val Asn Asn Ala Thr Ala Arg Val Met Thr 
             180                185                190
Asn Lys Lys Met Val Thr Pro Tyr Ala Asn Gly Trp Lys Leu Ser Pro 
         195                200                205
Val Val Gly Ala Val Tyr Gly Pro Glu Leu Tyr Ala Ala Ser Ser Phe 
     210                215                220
Gln Ala Asp Val Ser Leu Gly Asn Glu Ala Ala Val Pro Leu Ser Gly 
 225                230                235                240
Arg Gly Gly Ile Asn Thr Tyr Ile Pro Leu Ile Ile Pro Gly Phe Pro 
                 245                250                255
Tyr Pro Thr Ala Ala Thr Thr Ala Ala Ala Phe Arg Gly Ala His Leu 
             260                265                270
Arg Gly Arg Gly Arg Thr Val Tyr Gly Ala Val Arg Ala Val Pro Pro 
         275                280                285
Thr Ala Ile Pro Ala Tyr Pro Gly Val Val Tyr Gln Asp Gly Phe Tyr 
     290                295                300
Gly Ala Asp Leu Tyr Gly Gly Tyr Ala Ala Tyr Arg Tyr Ala Gln Pro 
 305                310                315                320
Ala Thr Ala Thr Ala Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Tyr 
                 325                330                335
Ser Asp Gly Tyr Gly Arg Val Tyr Thr Ala Asp Pro Tyr His Ala Leu 
             340                345                350
Ala Pro Ala Ala Ser Tyr Gly Val Gly Ala Val Ala Ser Leu Tyr Arg 
         355                360                365
Gly Gly Tyr Ser Arg Phe Ala Pro Tyr 
     370                375



<210> 7317
<211> 1876
<212> DNA
<213> Homo sapiens
<308> AL009266
<400> 7317

ctctaaaga  gaaacatta  aaagaaaaa  gaaggaaaa  ggtataaag  gagatcaat  60
acccaccct  aaatagcta  attgggggg  gaggggggt  gaaaagaaa  ctgtggagg  120
gtgccccag  acggctgct  tgaaaggtt  atcatctat  cgtttggtt  atggagaaa  180
agaaaatgg  aactcaggg  aaccaggag  cgacaacaa  tcctgacgc  atggttcag  240
cttttacta  catcccatt  ccaccacct  cgcagaatg  aattcccac  gagtatggg  300
tgccacaca  tcaagacta  gccggccag  ccggtgagc  taacctgac  ctctacgga  360
gtacgcaag  ccacgggga  cagagcagc  actcaccca  cacacaaaa  ggatctctt  420
cgcagacag  aggtggagc  cagacagac  gccagcagt  acagacaca  agtagtgaa  480
attcagaga  taaatctac  ccgaaacgg  tgcatgtct  taatattcc  ttccgcttc  540
gggaccctg  cctccggca  atgtttggg  agtttggca  aatcctaga  gtagaaata  600
tctttaatg  acgtggctc  aagggattc  ggttcgtaa  tttcgagaa  agtgctgat  660
cagacaggg  cagggagaa  ttacacggc  ccgtggtag  gggccgtaa  atcgaggtg  720
ataatgcta  agcacgtgt  atgaccaat  agaagatgg  cacaccata  gcaaatggt  780
ggaaattaa  cccagtagt  ggagctgta  atggtccgg  gttatatgc  gcatccagc  840
ttcaagcag  tgtgtccct  ggcaatgat  cagcagtgc  cctatcagg  agagggggt  900
tcaacactt  cattccttt  atcattcct  gcttccctt  ccctactgc  gccaccacg  960
cagccgctt  cagaggagc  catttgagg  gcagagggc  gacagtata  ggtgcagtc  1020
gagcggtac  tccaacagc  atccccgcc  atccagggg  ggatatgca  cctacagat  1080
tgcacagcc  gctactgca  ccgcagcca  cgctgctgc  gccgctgca  ccgcttaca  1140
tgacggtta  ggcagggtg  acacagccg  cccctacca  gcccttgcc  ctgccgcta  1200
ctatggagt  ggcgctgtg  cgagtttat  ccgaggtgg  tacagccga  ttgccccct  1260
ctgaagtga  gtgagaccc  tgcaaatgg  acagccccc  agttcatga  gcctggcta  1320
tgcaatatt  actagtaga  gaactctat  gcaagatga  gaggaaaaa  aaacaaaca  1380
acaaaaaaa  acacaaaaa  agaaagaat  cttttttat  cctcactat  ttctttgaa  1440
atgtatttt  cctttaaat  tctgccttt  attcttttg  tccaaagat  gtgcatttt  1500
ttctttttt  ttttaaact  tggtaaaaa  aaaaaaaaa  aatgcattt  catgtctgt  1560
tgtccgtgc  tagcttatt  tatcaatca  ggaagaggc  gtcaaggag  aaggagaga  1620
attaggagc  gataaatgc  tctgatcag  aatcagcag  cagaattac  aaagtgtat  1680
tggtgctga  tgactgggg  acaagcaga  gtggaagag  tctttctgc  acaggatat  1740
cttctagtc  tctgagttt  tggtctttg  caggcaatt  tggttggct  tggctggaa  1800
ccacatgct  atagatagg  atttgtgct  acaaagcag  agaattaaa  agacgcttt  1860
ctctcctcc  ttagag  1876



<210> 7318
<211> 391
<212> PRT
<213> Homo sapiens
<308> O43251
<400> 7318

Met Glu Lys Lys Lys Met Val Thr Gln Gly Asn Gln Glu Pro Thr Thr 
  1               5                  10                  15
Thr Pro Asp Ala Met Val Gln Pro Phe Thr Thr Ile Pro Phe Pro Pro 
             20                  25                  30
Pro Pro Gln Asn Gly Ile Pro Thr Glu Tyr Gly Val Pro His Thr Gln 
         35                  40                  45
Asp Tyr Ala Gly Gln Thr Gly Glu His Asn Leu Thr Leu Tyr Gly Ser 
     50                  55                  60
Thr Gln Ala His Gly Glu Gln Ser Ser Asn Ser Pro Ser Thr Gln Asn 
 65                  70                  75                  80
Gly Ser Leu Thr Gln Thr Glu Gly Gly Ala Gln Thr Asp Gly Gln Gln 
                 85                  90                  95
Ser Gln Thr Gln Ser Ser Glu Asn Ser Glu Ser Lys Ser Thr Pro Lys 
             100                105                110
Arg Leu His Val Ser Asn Ile Pro Phe Arg Phe Arg Asp Pro Asp Leu 
         115                120                125
Arg Gln Met Phe Gly Gln Phe Gly Lys Ile Leu Asp Val Glu Ile Ile 
     130                135                140
Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe Val Thr Phe Glu Asn 
 145                150                155                160
Ser Ala Asp Ala Asp Arg Ala Arg Glu Lys Leu His Gly Thr Val Val 
                 165                170                175
Glu Gly Arg Lys Ile Glu Val Asn Asn Ala Thr Ala Arg Val Met Thr 
             180                185                190
Asn Lys Lys Met Val Thr Pro Tyr Ala Asn Gly Trp Lys Leu Ser Pro 
         195                200                205
Val Val Gly Ala Val Tyr Gly Pro Glu Leu Tyr Ala Ala Ser Ser Phe 
     210                215                220
Gln Ala Asp Val Ser Leu Gly Asn Asp Ala Ala Val Pro Leu Ser Gly 
 225                230                235                240
Arg Gly Gly Ile Asn Thr Tyr Ile Pro Leu Ile Ile Pro Gly Phe Pro 
                 245                250                255
Tyr Pro Thr Ala Ala Thr Thr Ala Ala Ala Phe Arg Gly Ala His Leu 
             260                265                270
Arg Gly Arg Gly Arg Thr Val Tyr Gly Ala Val Arg Ala Val Pro Pro 
         275                280                285
Thr Ala Ile Pro Ala Tyr Pro Gly Val Val Tyr Gln Asp Gly Phe Tyr 
     290                295                300
Gly Ala Asp Leu Tyr Ile Glu Ser Ala Asn Cys Phe Arg Ser Asn Arg 
 305                310                315                320
Val Asp Met Gln Pro Thr Asp Met His Ser Leu Leu Leu Gln Pro Gln 
                 325                330                335
Pro Pro Leu Leu Gln Pro Leu Gln Pro Leu Thr Val Thr Val Met Ala 
             340                345                350
Gly Cys Thr Gln Pro Thr Pro Thr Met Pro Leu Pro Leu Pro Leu Ala 
         355                360                365
Met Glu Leu Ala Leu Trp Arg Val Tyr Thr Glu Val Ala Thr Ala Asp 
     370                375                380
Leu Pro Pro Thr Glu Val Thr 
 385                390



<210> 7319
<211> 393
<212> DNA
<213> Rattus norvegicus
<308> AI638958
<400> 7319

ttggggagg  gtctaatgc  gttatggct  tcctggaac  atgtagacc  agatgacct  60
aaactcaga  aaagccacc  gcttatacc  tcagaatac  cccactaca  ctgctttag  120
ctttacgtt  cctcaggaa  tccaacatc  gactgcagg  tctcaaggc  acttcttat  180
caatcactg  agcccactc  ctcactcac  cactcaggc  gttgtactt  gttaaagag  240
atatgagtg  cacaggcct  ttctctgac  ctgctgttc  tcttaggaa  aacctggct  300
gaggcagta  ctgggacct  ctggatcaa  cctcctaga  gaatgccca  cgaagctag  360
ccccaggtc  aatttccta  ttctgacag  atg  393



<210> 7320
<211> 584
<212> DNA
<213> Rattus norvegicus
<308> AI638960
<400> 7320

ttgactcag  agcagacgt  tatttactt  aaacatttc  caattatat  gacaattat  60
tatttaaaa  aatattcta  atacttaca  aaataaatc  agtattgct  ctagttttc  120
agtgtgaca  catttgcca  agaaaatag  agggacctt  tgaataaac  aaacgctac  180
ctgaaactt  ctcaagttt  ataactaca  actatttcc  ctgatgact  gtgctttat  240
aatgtccaa  ctatttctg  gcaacaaac  ggatcacag  aagactgaa  gtataacaa  300
ccatataca  tcattttta  acaaaatgt  agtactctg  cccaaacca  catcatccc  360
aaaatgcca  atacaccat  atacagaag  acatgtggt  gtgaagttt  taacatcca  420
tcatcaaag  ccagatatt  attattaaa  tatactcag  taaaggttg  taggcaaga  480
attttttac  tacattaaa  cattagtca  atcattaaa  aaatagaat  aacttcaaa  540
atgtctcaa  acattaagt  aatcccaag  taaacatca  tgtc  584



<210> 7321
<211> 2214
<212> DNA
<213> Homo sapiens
<308> AK027250
<400> 7321

aaatttaat  aattataaa  tcagtctct  ggttgcacc  gccacattt  agatgctca  60
tagccacat  tggctagtg  gtaccatat  ggacagggc  gctatagaa  atttccatc  120
ttgcagaaa  ttctattgg  tagtaccat  atcttttta  agtaacttg  aaatactat  180
tgatattag  tgttagacc  caaaaagaa  aaaaatgtt  ggactattt  agatataaa  240
aggaactga  ttgtgacat  attagcatc  tacattcca  acagttgaa  accttatgc  300
gtgacaacc  tagttaatc  tttcagtgc  gttcaacat  catacctat  agcagtgtg  360
ttagaccag  ggtctgcaa  ctttctgtg  atggacaaa  agtaaatac  ttagtaaat  420
tcttaggct  tgtggccta  atgatcttt  ttgcaagta  tcaactctg  cattataga  480
ttaaagcag  catacacaa  atataaaca  aatgggcat  gttgtattt  agtaaaact  540
tatttacaa  gacaggcgg  aggccagat  tggcttgca  gctgtagag  tgtggtcta  600
attttattc  tagactttc  ttgcaaata  agtgtgagt  ttgttccat  tacagtatt  660
ttatttttt  gatacctgg  ttttagatt  ttgcctggt  actttttac  gaaaataca  720
gaatttcgt  ctgcatttg  atctccgag  ttagggagc  cctgtcagg  tatgttgtt  780
tatcagggt  acttctgtt  actacctct  agattttga  acagttata  tgttgagtt  840
cattttcat  tattcttgt  gtgtctgct  gcctgtgac  tctggtaaa  taaaataag  900
ctttgaaaa  attttagca  ggtatttaa  attttctaa  tattatggc  ttttgacat  960
ttttagtca  cgaagacat  tgccccttt  gtgtttcta  ttgcttatg  ttgagattt  1020
acaagccct  caaactccg  tttaaagga  tttattgta  aacattaac  ttaataaat  1080
agtgttttc  cagatcaga  cattatact  ggaacttct  aatcatgca  tttctgaat  1140
aggacataa  gctagattc  tttttctta  tagagaaaa  ggaaatttc  gatttatca  1200
ttttctagt  gataagtag  attcaaaac  tttgatatg  aagtattta  ataagacta  1260
tgtaattta  agttctgta  tattgtgat  aatcataca  aaattcagg  actgatcag  1320
agtgagatt  ttttccaca  ctggttaat  tagtgagtt  acaccctgt  ggtggtaaa  1380
cattataaa  atttcatct  gaaccatga  ttatacaca  ctgtgttat  agggaggct  1440
gagtacata  accaatgaa  agatattca  catttgtct  tttgataag  aattaaatg  1500
cctagtgat  ataaagtaa  accacagac  aatttgcaa  tgatcttca  tgttaagca  1560
ttgctctaa  attaaaatt  cttttcttt  taaggttaa  ggtgtgtac  tatggcagt  1620
atgtctatg  tgagattaa  ttatgtatt  aggaaaatt  gaagtttat  ttttcgatg  1680
ataaggctg  caaatgatt  agtatagat  aatgacatc  tttttagaa  tattaaagt  1740
agtattcct  attatgtca  catttctga  aattagagt  ctaatttga  tgttagata  1800
tgtttccac  tctatacct  tttctttct  gggcacttc  gaccctggg  cttggggat  1860
gcctttagg  cacagtagt  tctgtgtta  gttcactaa  tgtgtattt  atgagaaac  1920
ttcctatgt  aaaatgtgt  tatgtgaac  tatgcatac  tttttattg  gcacctgta  1980
attgtgaag  agtagtttg  aaatttgta  agcacaaac  ataaaagag  gtggagtta  2040
taaatgatg  agcacaaat  taatgttta  cttataaaa  gtcctttct  ttttctatg  2100
caaagactt  gacacttga  aaataaaac  aatatttga  ttatttttg  aagtattta  2160
gatattatt  taaataaat  attgtccat  atcaataaa  aaaaaaaaa  aaaa  2214



<210> 7322
<211> 584
<212> DNA
<213> Rattus norvegicus
<308> AI638960
<400> 7322

ttgactcag  agcagacgt  tatttactt  aaacatttc  caattatat  gacaattat  60
tatttaaaa  aatattcta  atacttaca  aaataaatc  agtattgct  ctagttttc  120
agtgtgaca  catttgcca  agaaaatag  agggacctt  tgaataaac  aaacgctac  180
ctgaaactt  ctcaagttt  ataactaca  actatttcc  ctgatgact  gtgctttat  240
aatgtccaa  ctatttctg  gcaacaaac  ggatcacag  aagactgaa  gtataacaa  300
ccatataca  tcattttta  acaaaatgt  agtactctg  cccaaacca  catcatccc  360
aaaatgcca  atacaccat  atacagaag  acatgtggt  gtgaagttt  taacatcca  420
tcatcaaag  ccagatatt  attattaaa  tatactcag  taaaggttg  taggcaaga  480
attttttac  tacattaaa  cattagtca  atcattaaa  aaatagaat  aacttcaaa  540
atgtctcaa  acattaagt  aatcccaag  taaacatca  tgtc  584



<210> 7323
<211> 2214
<212> DNA
<213> Homo sapiens
<308> AK027250
<400> 7323

aaatttaat  aattataaa  tcagtctct  ggttgcacc  gccacattt  agatgctca  60
tagccacat  tggctagtg  gtaccatat  ggacagggc  gctatagaa  atttccatc  120
ttgcagaaa  ttctattgg  tagtaccat  atcttttta  agtaacttg  aaatactat  180
tgatattag  tgttagacc  caaaaagaa  aaaaatgtt  ggactattt  agatataaa  240
aggaactga  ttgtgacat  attagcatc  tacattcca  acagttgaa  accttatgc  300
gtgacaacc  tagttaatc  tttcagtgc  gttcaacat  catacctat  agcagtgtg  360
ttagaccag  ggtctgcaa  ctttctgtg  atggacaaa  agtaaatac  ttagtaaat  420
tcttaggct  tgtggccta  atgatcttt  ttgcaagta  tcaactctg  cattataga  480
ttaaagcag  catacacaa  atataaaca  aatgggcat  gttgtattt  agtaaaact  540
tatttacaa  gacaggcgg  aggccagat  tggcttgca  gctgtagag  tgtggtcta  600
attttattc  tagactttc  ttgcaaata  agtgtgagt  ttgttccat  tacagtatt  660
ttatttttt  gatacctgg  ttttagatt  ttgcctggt  actttttac  gaaaataca  720
gaatttcgt  ctgcatttg  atctccgag  ttagggagc  cctgtcagg  tatgttgtt  780
tatcagggt  acttctgtt  actacctct  agattttga  acagttata  tgttgagtt  840
cattttcat  tattcttgt  gtgtctgct  gcctgtgac  tctggtaaa  taaaataag  900
ctttgaaaa  attttagca  ggtatttaa  attttctaa  tattatggc  ttttgacat  960
ttttagtca  cgaagacat  tgccccttt  gtgtttcta  ttgcttatg  ttgagattt  1020
acaagccct  caaactccg  tttaaagga  tttattgta  aacattaac  ttaataaat  1080
agtgttttc  cagatcaga  cattatact  ggaacttct  aatcatgca  tttctgaat  1140
aggacataa  gctagattc  tttttctta  tagagaaaa  ggaaatttc  gatttatca  1200
ttttctagt  gataagtag  attcaaaac  tttgatatg  aagtattta  ataagacta  1260
tgtaattta  agttctgta  tattgtgat  aatcataca  aaattcagg  actgatcag  1320
agtgagatt  ttttccaca  ctggttaat  tagtgagtt  acaccctgt  ggtggtaaa  1380
cattataaa  atttcatct  gaaccatga  ttatacaca  ctgtgttat  agggaggct  1440
gagtacata  accaatgaa  agatattca  catttgtct  tttgataag  aattaaatg  1500
cctagtgat  ataaagtaa  accacagac  aatttgcaa  tgatcttca  tgttaagca  1560
ttgctctaa  attaaaatt  cttttcttt  taaggttaa  ggtgtgtac  tatggcagt  1620
atgtctatg  tgagattaa  ttatgtatt  aggaaaatt  gaagtttat  ttttcgatg  1680
ataaggctg  caaatgatt  agtatagat  aatgacatc  tttttagaa  tattaaagt  1740
agtattcct  attatgtca  catttctga  aattagagt  ctaatttga  tgttagata  1800
tgtttccac  tctatacct  tttctttct  gggcacttc  gaccctggg  cttggggat  1860
gcctttagg  cacagtagt  tctgtgtta  gttcactaa  tgtgtattt  atgagaaac  1920
ttcctatgt  aaaatgtgt  tatgtgaac  tatgcatac  tttttattg  gcacctgta  1980
attgtgaag  agtagtttg  aaatttgta  agcacaaac  ataaaagag  gtggagtta  2040
taaatgatg  agcacaaat  taatgttta  cttataaaa  gtcctttct  ttttctatg  2100
caaagactt  gacacttga  aaataaaac  aatatttga  ttatttttg  aagtattta  2160
gatattatt  taaataaat  attgtccat  atcaataaa  aaaaaaaaa  aaaa  2214



<210> 7324
<211> 450
<212> DNA
<213> Rattus norvegicus
<308> AI638965
<400> 7324

ttgctgttg  gttttgttt  aaaccctca  attttccgc  ttaatttat  ctgaattta  60
tcccacgcc  tgagctttg  tttgttcaa  ttctgctgg  atatctttt  cttttgggc  120
acctcctgt  ctggctttg  aacaatctg  tccttctaa  tgagctgtc  cacggcact  180
acccggttt  acaatgcgc  agtagtcac  tccactcgc  gaatttaca  ccgtggtgg  240
tgccgctca  agagatggt  ccattgaca  tggggatcc  ttgctcata  cgccaccaa  300
cgcttgatg  cacggtgca  ctgctccat  aaggttagc  aggcttatt  gttgatgtc  360
cactctcgg  gcagctaga  ctagggggg  aacttgtcg  atcccatgt  tatagagag  420
tccaggcat  tgttatgca  gtagctgaag  450



<210> 7325
<211> 407
<212> DNA
<213> Rattus norvegicus
<308> AI638974
<400> 7325

ttgatggct  actgactaa  ctgagtcgc  gctgtagag  gagccgtag  gaacaccgc  60
tgttctgtc  aggagcata  agtgcttac  aaacatggg  tgatgctat  ctgctcctc  120
cagactgcc  tgagaaggg  aaacacacg  tgaagtaaa  ggcggtgag  tgccaactt  180
aggtgtgtg  tttggcgat  atacatgga  cacccactc  gtcttacca  gtcttagcc  240
atcgagccg  gtctgggta  agagaaaac  cttttctag  ccattactc  taagtcacc  300
cggcttccc  ggatagcta  ctatataaa  caaggtaat  caaaagtgt  ttgtctgta  360
attaatact  gaaatgaag  ctgtttaaa  agtgacttt  gagccca  407



<210> 7326
<211> 1333
<212> PRT
<213> Rattus norvegicus
<308> NP_034358
<400> 7326

Met Val Ser Cys Trp Asp Thr Ala Val Leu Pro Tyr Ala Leu Leu Gly 
  1               5                  10                  15
Cys Leu Leu Leu Thr Gly Tyr Gly Ser Gly Ser Lys Leu Lys Val Pro 
             20                  25                  30
Glu Leu Ser Leu Lys Gly Thr Gln His Val Met Gln Ala Gly Gln Thr 
         35                  40                  45
Leu Phe Leu Lys Cys Arg Gly Glu Ala Ala His Ser Trp Ser Leu Pro 
     50                  55                  60
Thr Thr Val Ser Gln Glu Asp Lys Arg Leu Ser Ile Thr Pro Pro Ser 
 65                  70                  75                  80
Ala Cys Gly Arg Asp Asn Arg Gln Phe Cys Ser Thr Leu Thr Leu Asp 
                 85                  90                  95
Thr Ala Gln Ala Asn His Thr Gly Leu Tyr Thr Cys Arg Tyr Leu Pro 
             100                105                110
Thr Ser Thr Ser Lys Lys Lys Lys Ala Glu Ser Ser Ile Tyr Ile Phe 
         115                120                125
Val Ser Asp Ala Gly Ser Pro Phe Ile Glu Met His Thr Asp Ile Pro 
     130                135                140
Lys Leu Val His Met Thr Glu Gly Arg Gln Leu Ile Ile Pro Cys Arg 
 145                150                155                160
Val Thr Ser Pro Asn Val Thr Val Thr Leu Lys Lys Phe Pro Phe Asp 
                 165                170                175
Thr Leu Thr Pro Asp Gly Gln Arg Ile Thr Trp Asp Ser Arg Arg Gly 
             180                185                190
Phe Ile Ile Ala Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Asn Cys 
         195                200                205
Glu Ala Thr Val Asn Gly His Leu Tyr Gln Thr Asn Tyr Leu Thr His 
     210                215                220
Arg Gln Thr Asn Thr Ile Leu Asp Val Gln Ile Arg Pro Pro Ser Pro 
 225                230                235                240
Val Arg Leu Leu His Gly Gln Thr Leu Val Leu Asn Cys Thr Ala Thr 
                 245                250                255
Thr Glu Leu Asn Thr Arg Val Gln Met Ser Trp Asn Tyr Pro Gly Lys 
             260                265                270
Ala Thr Lys Arg Ala Ser Ile Arg Gln Arg Ile Asp Arg Ser His Ser 
         275                280                285
His Asn Asn Val Phe His Ser Val Leu Lys Ile Asn Asn Val Glu Ser 
     290                295                300
Arg Asp Lys Gly Leu Tyr Thr Cys Arg Val Lys Ser Gly Ser Ser Phe 
 305                310                315                320
Gln Ser Phe Asn Thr Ser Val His Val Tyr Glu Lys Gly Phe Ile Ser 
                 325                330                335
Val Lys His Arg Lys Gln Pro Val Gln Glu Thr Thr Ala Gly Arg Arg 
             340                345                350
Ser Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Ile 
         355                360                365
Val Trp Leu Lys Asp Gly Ser Pro Ala Thr Leu Lys Ser Ala Arg Tyr 
     370                375                380
Leu Val His Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Thr Glu Asp 
 385                390                395                400
Ala Gly Asp Tyr Thr Ile Leu Leu Gly Ile Lys Gln Ser Arg Leu Phe 
                 405                410                415
Lys Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr 
             420                425                430
Glu Lys Ser Val Ser Ser Leu Pro Ser Pro Pro Leu Tyr Pro Leu Gly 
         435                440                445
Ser Arg Gln Val Leu Thr Cys Thr Val Tyr Gly Ile Pro Arg Pro Thr 
     450                455                460
Ile Thr Trp Leu Trp His Pro Cys His His Asn His Ser Lys Glu Arg 
 465                470                475                480
Tyr Asp Phe Cys Thr Glu Asn Glu Glu Ser Phe Ile Leu Asp Pro Ser 
                 485                490                495
Ser Asn Leu Gly Asn Arg Ile Glu Ser Ile Ser Gln Arg Met Thr Val 
             500                505                510
Ile Glu Gly Thr Asn Lys Thr Val Ser Thr Leu Val Val Ala Asp Ser 
         515                520                525
Gln Thr Pro Gly Ile Tyr Ser Cys Arg Ala Phe Asn Lys Ile Gly Thr 
     530                535                540
Val Glu Arg Asn Ile Lys Phe Tyr Val Thr Asp Val Pro Asn Gly Phe 
 545                550                555                560
His Val Ser Leu Glu Lys Met Pro Ala Glu Gly Glu Asp Leu Lys Leu 
                 565                570                575
Ser Cys Val Val Asn Lys Phe Leu Tyr Arg Asp Ile Thr Trp Ile Leu 
             580                585                590
Leu Arg Thr Val Asn Asn Arg Thr Met His His Ser Ile Ser Lys Gln 
         595                600                605
Lys Met Ala Thr Thr Gln Asp Tyr Ser Ile Thr Leu Asn Leu Val Ile 
     610                615                620
Lys Asn Val Ser Leu Glu Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg 
 625                630                635                640
Asn Ile Tyr Thr Gly Glu Asp Ile Leu Arg Lys Thr Glu Val Leu Val 
                 645                650                655
Arg Asp Ser Glu Ala Pro His Leu Leu Gln Asn Leu Ser Asp Tyr Glu 
             660                665                670
Val Ser Ile Ser Gly Ser Thr Thr Leu Asp Cys Gln Ala Arg Gly Val 
         675                680                685
Pro Ala Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln 
     690                695                700
Glu Pro Gly Ile Ile Leu Gly Pro Gly Asn Ser Thr Leu Phe Ile Glu 
 705                710                715                720
Arg Val Thr Glu Glu Asp Glu Gly Val Tyr Arg Cys Arg Ala Thr Asn 
                 725                730                735
Gln Lys Gly Ala Val Glu Ser Ala Ala Tyr Leu Thr Val Gln Gly Thr 
             740                745                750
Ser Asp Lys Ser Asn Leu Glu Leu Ile Thr Leu Thr Cys Thr Cys Val 
         755                760                765
Ala Ala Thr Leu Phe Trp Leu Leu Leu Thr Leu Phe Ile Arg Lys Leu 
     770                775                780
Lys Arg Ser Ser Ser Glu Val Lys Thr Asp Tyr Leu Ser Ile Ile Met 
 785                790                795                800
Asp Pro Asp Glu Val Pro Leu Asp Glu Gln Cys Glu Arg Leu Pro Tyr 
                 805                810                815
Asp Ala Ser Lys Trp Glu Phe Ala Arg Glu Arg Leu Lys Leu Gly Lys 
             820                825                830
Ser Leu Gly Arg Gly Ala Phe Gly Lys Val Val Gln Ala Ser Ala Phe 
         835                840                845
Gly Ile Lys Lys Ser Pro Thr Cys Arg Thr Val Ala Val Lys Met Leu 
     850                855                860
Lys Glu Gly Ala Thr Ala Ser Glu Tyr Lys Ala Leu Met Thr Glu Leu 
 865                870                875                880
Lys Ile Leu Thr His Ile Gly His His Leu Asn Val Val Asn Leu Leu 
                 885                890                895
Gly Ala Cys Thr Lys Gln Gly Gly Pro Leu Met Val Ile Val Glu Tyr 
             900                905                910
Cys Lys Tyr Gly Asn Leu Ser Asn Tyr Leu Lys Ser Lys Arg Asp Leu 
         915                920                925
Phe Cys Leu Asn Lys Asp Ala Ala Leu His Met Glu Leu Lys Lys Glu 
     930                935                940
Ser Leu Glu Pro Gly Leu Glu Gln Gly Gln Lys Pro Arg Leu Asp Ser 
 945                950                955                960
Val Ser Ser Ser Ser Val Thr Ser Ser Ser Phe Pro Glu Asp Arg Ser 
                 965                970                975
Val Ser Asp Val Glu Gly Asp Glu Asp Tyr Ser Glu Ile Ser Lys Gln 
             980                985                990
Pro Leu Thr Met Glu Asp Leu Ile Ser Tyr Ser Phe Gln Val Ala Arg 
         995                1000                1005
Gly Met Glu Phe Leu Ser Ser Arg Lys Cys Ile His Arg Asp Leu Ala 
     1010                1015                1020
Ala Arg Asn Ile Leu Leu Ser Glu Asn Asn Val Val Lys Ile Cys Asp 
 1025                1030                1035                1040
Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asn Pro Asp Tyr Val Arg Arg 
                 1045                1050                1055
Gly Asp Thr Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe 
             1060                1065                1070
Asp Lys Val Tyr Ser Thr Lys Ser Asp Val Trp Ser Tyr Gly Val Leu 
         1075                1080                1085
Leu Trp Glu Ile Phe Ser Leu Gly Gly Ser Pro Tyr Pro Gly Val Gln 
     1090                1095                1100
Met Asp Glu Asp Phe Cys Ser Arg Leu Lys Glu Gly Met Arg Met Arg 
 1105                1110                1115                1120
Thr Pro Glu Tyr Ala Thr Pro Glu Ile Tyr Gln Ile Met Leu Asp Cys 
                 1125                1130                1135
Trp His Lys Asp Pro Lys Glu Arg Pro Arg Phe Ala Glu Leu Val Glu 
             1140                1145                1150
Lys Leu Gly Asp Leu Leu Gln Ala Asn Val Gln Gln Asp Gly Lys Asp 
         1155                1160                1165
Tyr Ile Pro Leu Asn Ala Ile Leu Thr Arg Asn Ser Ser Phe Thr Tyr 
     1170                1175                1180
Ser Thr Pro Thr Phe Ser Glu Asp Leu Phe Lys Asp Gly Phe Ala Asp 
 1185                1190                1195                1200
Pro His Phe His Ser Gly Ser Ser Asp Asp Val Arg Tyr Val Asn Ala 
                 1205                1210                1215
Phe Lys Phe Met Ser Leu Glu Arg Ile Lys Thr Phe Glu Glu Leu Ser 
             1220                1225                1230
Pro Asn Ser Thr Ser Met Phe Glu Asp Tyr Gln Leu Asp Thr Ser Thr 
         1235                1240                1245
Leu Leu Gly Ser Pro Leu Leu Lys Arg Phe Thr Trp Thr Glu Thr Lys 
     1250                1255                1260
Pro Lys Ala Ser Met Lys Ile Asp Leu Arg Ile Ala Ser Lys Ser Lys 
 1265                1270                1275                1280
Glu Ala Gly Leu Ser Asp Leu Pro Arg Pro Ser Phe Cys Phe Ser Ser 
                 1285                1290                1295
Cys Gly His Ile Arg Pro Val Gln Asp Asp Glu Ser Glu Leu Gly Lys 
             1300                1305                1310
Glu Ser Cys Cys Ser Pro Pro Pro Asp Tyr Asn Ser Val Val Leu Tyr 
         1315                1320                1325
Ser Ser Pro Pro Ala 
     1330



<210> 7328
<211> 572
<212> PRT
<213> Homo sapiens
<308> Q15942
<400> 7328

Met Ala Ala Pro Arg Pro Ser Pro Ala Ile Ser Val Ser Val Ser Ala 
  1               5                  10                  15
Pro Ala Phe Tyr Ala Pro Gln Lys Lys Phe Gly Pro Val Val Ala Pro 
             20                  25                  30
Lys Pro Lys Val Asn Pro Phe Arg Pro Gly Asp Ser Glu Pro Pro Pro 
         35                  40                  45
Ala Pro Gly Ala Gln Arg Ala Gln Met Gly Arg Val Gly Glu Ile Pro 
     50                  55                  60
Pro Pro Pro Pro Glu Asp Phe Pro Leu Pro Pro Pro Pro Leu Ala Gly 
 65                  70                  75                  80
Asp Gly Asp Asp Ala Glu Gly Ala Leu Gly Gly Ala Phe Pro Pro Pro 
                 85                  90                  95
Pro Pro Pro Ile Glu Glu Ser Phe Pro Pro Ala Pro Leu Glu Glu Glu 
             100                105                110
Ile Phe Pro Ser Pro Pro Pro Pro Pro Glu Glu Glu Gly Gly Pro Glu 
         115                120                125
Ala Pro Ile Pro Pro Pro Pro Gln Pro Arg Glu Lys Val Ser Ser Ile 
     130                135                140
Asp Leu Glu Ile Asp Ser Leu Ser Ser Leu Leu Asp Asp Met Thr Lys 
 145                150                155                160
Asn Asp Pro Phe Lys Ala Arg Val Ser Ser Gly Tyr Val Pro Pro Pro 
                 165                170                175
Val Ala Thr Pro Phe Ser Ser Lys Ser Ser Thr Lys Pro Ala Ala Gly 
             180                185                190
Gly Thr Ala Pro Leu Pro Pro Trp Lys Ser Pro Ser Ser Ser Gln Pro 
         195                200                205
Leu Pro Gln Val Pro Ala Pro Ala Gln Ser Gln Thr Gln Phe His Val 
     210                215                220
Gln Pro Gln Pro Gln Pro Lys Pro Gln Val Gln Leu His Val Gln Ser 
 225                230                235                240
Gln Thr Gln Pro Val Ser Leu Ala Asn Thr Gln Pro Arg Gly Pro Pro 
                 245                250                255
Ala Ser Ser Pro Ala Pro Ala Pro Lys Phe Ser Pro Val Thr Pro Lys 
             260                265                270
Phe Thr Pro Val Ala Ser Lys Phe Ser Pro Gly Ala Pro Gly Gly Ser 
         275                280                285
Gly Ser Gln Pro Asn Gln Lys Leu Gly His Pro Glu Ala Leu Ser Ala 
     290                295                300
Gly Thr Gly Ser Pro Gln Pro Pro Ser Phe Thr Tyr Ala Gln Gln Arg 
 305                310                315                320
Glu Lys Pro Arg Val Gln Glu Lys Gln His Pro Val Pro Pro Pro Ala 
                 325                330                335
Gln Asn Gln Asn Gln Val Arg Ser Pro Gly Ala Pro Gly Pro Leu Thr 
             340                345                350
Leu Lys Glu Val Glu Glu Leu Glu Gln Leu Thr Gln Gln Leu Met Gln 
         355                360                365
Asp Met Glu His Pro Gln Arg Gln Asn Val Ala Val Asn Glu Leu Cys 
     370                375                380
Gly Arg Cys His Gln Pro Leu Ala Arg Ala Gln Pro Ala Val Arg Ala 
 385                390                395                400
Leu Gly Gln Leu Phe His Ile Ala Cys Phe Thr Cys His Gln Cys Ala 
                 405                410                415
Gln Gln Leu Gln Gly Gln Gln Phe Tyr Ser Leu Glu Gly Ala Pro Tyr 
             420                425                430
Cys Glu Gly Cys Tyr Thr Asp Thr Leu Glu Lys Cys Asn Thr Cys Gly 
         435                440                445
Glu Pro Ile Thr Asp Arg Met Leu Arg Ala Thr Gly Lys Ala Tyr His 
     450                455                460
Pro His Cys Phe Thr Cys Val Val Cys Ala Arg Pro Leu Glu Gly Thr 
 465                470                475                480
Ser Phe Ile Val Asp Gln Ala Asn Arg Pro His Cys Val Pro Asp Tyr 
                 485                490                495
His Lys Gln Tyr Ala Pro Arg Cys Ser Val Cys Ser Glu Pro Ile Met 
             500                505                510
Pro Glu Pro Gly Arg Asp Glu Thr Val Arg Val Val Ala Leu Asp Lys 
         515                520                525
Asn Phe His Met Lys Cys Tyr Lys Cys Glu Asp Cys Gly Lys Pro Leu 
     530                535                540
Ser Ile Glu Ala Asp Asp Asn Gly Cys Phe Pro Leu Asp Gly His Val 
 545                550                555                560
Leu Cys Arg Lys Cys His Thr Ala Arg Ala Gln Thr 
                 565                570



<210> 7329
<211> 426
<212> DNA
<213> Rattus norvegicus
<308> AI638989
<400> 7329

ttctctcaa  acttggtag  tcaggggaa  atccatccc  agtggctct  cgcttcttt  60
taatactgg  gccatcgtt  tgctcagta  cagaggtac  actgctgtc  gtggctgca  120
cagctaagc  ggagactgc  tgacctgaa  atgatgcag  tgatgaaag  gggtttcct  180
ctccagtgc  ctcctgggt  tggtgctct  atagtgggg  agtcctctc  tggctatgc  240
ggtctctgg  tgaatgcat  aaaggcatt  tgtgatcag  tggtaactg  gcgctatgt  300
gccgctggg  aggaccggt  ccaaccctt  cacctgttc  gacagaggg  gacagaggt  360
ccacttccg  ttcaagata  atggctgcc  tctgagatg  agtactagg  gaaggactc  420
gctggg  426



<210> 7330
<211> 1888
<212> PRT
<213> Rattus norvegicus
<308> AAD04329
<400> 7330

Met Val Arg Glu Arg Lys Cys Ile Leu Cys His Ile Val Tyr Gly Ser 
  1               5                  10                  15
Lys Lys Glu Met Asp Glu His Met Arg Ser Met Leu His His Arg Glu 
             20                  25                  30
Leu Glu Asn Leu Lys Gly Arg Asp Ile Ser His Glu Cys Arg Val Cys 
         35                  40                  45
Arg Val Thr Glu Val Gly Leu Ser Ala Tyr Ala Lys His Ile Ser Gly 
     50                  55                  60
Gln Leu His Lys Asp Asn Val Asp Ala Gln Glu Arg Glu Asp Asp Gly 
 65                  70                  75                  80
Lys Glu Glu Glu Glu Glu Glu Tyr Phe Asp Lys Glu Leu Val Gln Leu 
                 85                  90                  95
Ile Gln Glu Arg Lys Glu Gln Ser Arg Gln Asp Glu Pro Pro Ser Asn 
             100                105                110
Ser Gln Glu Val Asn Ser Asp Asp Arg Gln Pro Gln Trp Arg Arg Glu 
         115                120                125
Asp Arg Ile Pro Tyr Gln Asp Arg Glu Ser Tyr Ser Gln Pro Pro Arg 
     130                135                140
His His Arg Gly Pro Pro Gln Arg Asp Trp Lys Trp Glu Lys Asp Gly 
 145                150                155                160
Phe Asn Ser Thr Arg Lys Asn Ser Phe Pro His Ser Leu Arg Asn Ser 
                 165                170                175
Gly Gly Pro Arg Gly Ser Ser Val Trp His Lys Gly Ala Thr Arg Gly 
             180                185                190
Ser Ser Thr Trp Phe Leu Asn His Ser Asn Ser Gly Gly Gly Trp His 
         195                200                205
Ser Asn Asn Gly Met Val Asp Trp Asn Tyr Asn Gly Thr Gly Arg Asn 
     210                215                220
Ser Ser Trp His Ser Glu Gly Thr Gly Gly Phe Pro Ser Trp His Met 
 225                230                235                240
Asn Asn Ser Asn Gly Asn Trp Lys Ser Ser Val Arg Ser Thr Asn Ser 
                 245                250                255
Trp Asn Tyr Asn Gly Pro Gly Asp Lys Phe Gln Gln Gly Arg Asn Arg 
             260                265                270
Asn Pro Asn Tyr Gln Met Glu Asp Met Thr Lys Met Trp Asn Lys Lys 
         275                280                285
Ser Asn Lys Pro Ser Lys Tyr Ser Gln Glu Arg Cys Lys Trp Gln Arg 
     290                295                300
Gln Asp Arg Asp Lys Ala Ala Lys Tyr Arg Ser Pro Pro Glu Gly Tyr 
 305                310                315                320
Ala Ser Asp Thr Phe Pro Ser Glu Gly Leu Leu Glu Phe Asn Phe Glu 
                 325                330                335
Gln Arg Glu Ser Gln Thr Thr Lys Gln Thr Asp Thr Ala Ala Ser Lys 
             340                345                350
Ile Asn Gly Lys Asn Gly Thr Lys Ala Arg Asp Lys Phe Arg Arg Trp 
         355                360                365
Thr Pro Tyr Pro Ser Gln Lys Thr Leu Asp Leu Gln Ser Ala Leu Lys 
     370                375                380
Glu Val Ile Gly Ser Lys Ser Asp Thr Leu Glu Lys Pro Leu Phe Asn 
 385                390                395                400
Phe Ser Leu Ile Thr Ala Gly Leu Arg Lys Pro Val Asp Lys Thr Ser 
                 405                410                415
Asn Pro Pro Val Ile Lys Thr Gln Lys Ala Gly Pro Pro Gly Ser Pro 
             420                425                430
Ser His Lys Ala Ile Ser Asp Gly Thr Ala Phe Cys Glu Val Pro Arg 
         435                440                445
Ala Cys Pro Ile Thr Glu Gln Ser Glu Pro His Gln Lys Ser Asn Lys 
     450                455                460
Ile Pro Leu Leu Lys Ser Pro Leu Leu Pro Leu Pro Thr Pro Lys Ser 
 465                470                475                480
Gly Pro His Lys Gln Asn Leu Lys Asn Arg Ser Lys Asn Lys Glu Thr 
                 485                490                495
Lys Ser Phe Pro Ser Gly Asp His Ser His Leu Leu Asn Thr Ser Thr 
             500                505                510
Leu Glu Gly Ser His Gly Ser Ser Tyr Thr Ser Lys Ser Arg Gly Leu 
         515                520                525
Cys Pro Arg Val Leu Lys Glu Asn Lys Thr Val Ser Gly Thr Gln Lys 
     530                535                540
Glu Pro Asp Glu Lys Leu Asn Ser Thr Ser Gln Lys Ala Gln Asp Thr 
 545                550                555                560
Val Leu Gln Cys Pro Lys Thr Leu Gln Asn Pro Leu Pro Thr Thr Pro 
                 565                570                575
Lys Arg Thr Glu Asn Asp Ala Lys Glu Ser Ser Val Glu Glu Ser Ala 
             580                585                590
Lys Asp Ser Leu Ser Ile Glu Ser Gln Pro His Ser Ala Gly Asn Ser 
         595                600                605
Ala Met Thr Ser Asp Ala Glu Asn His Gly Ile Lys Ser Glu Gly Val 
     610                615                620
Ala Ser Leu Thr Thr Glu Val Val Ser Cys Ser Thr His Thr Val Asp 
 625                630                635                640
Lys Glu Gln Gly Ser Gln Ile Pro Gly Thr Pro Glu Asn Leu Ser Ala 
                 645                650                655
Ser Pro Cys Asn Ser Thr Val Leu Gln Lys Glu Ala Glu Val Gln Val 
             660                665                670
Ser Ala Ala Thr Ser Pro His Ser Gly Leu Leu Leu Asn Leu Lys Thr 
         675                680                685
Ser Leu Glu Asp Ala Gln Asp Asn Asn Leu Val Lys Ser Asp Gly Pro 
     690                695                700
Phe Glu Thr Glu Ser Phe Glu Asp Thr Ser Leu Asp Ala Glu Leu Gln 
 705                710                715                720
Lys Pro Asp Leu Asn Asn Gln Pro Pro Gly Thr Leu Leu Pro Glu Leu 
                 725                730                735
Ser Lys Leu Gly Phe Pro Ala Ser Leu Gln Arg Asp Leu Ser Arg His 
             740                745                750
Ile Ser Leu Lys Ser Lys Thr Gly Thr His Leu Pro Glu Pro Asn Leu 
         755                760                765
Asn Ser Ala Arg Arg Ile Arg Asn Val Cys Gly His Arg Lys Asn Glu 
     770                775                780
Thr Glu Lys Glu Ser Gly Leu Lys Pro Thr Leu Arg Gln Ile Leu Asn 
 785                790                795                800
Ala Ser Arg Arg Asn Val Asn Trp Glu Gln Val Ile Gln Gln Val Thr 
                 805                810                815
Lys Lys Lys Gln Glu Leu Gly Lys Gly Leu Pro Arg Phe Gly Ile Glu 
             820                825                830
Met Val Pro Leu Val Gln Asn Glu Gln Glu Val Leu Asp Leu Asp Glu 
         835                840                845
Glu Pro Asp Leu Ser Ser Leu Glu Gly Phe Gln Trp Glu Gly Val Ser 
     850                855                860
Ile Pro Ser Ser Ser Gly Leu Ala Arg Lys Arg Ser Leu Ser Glu Ser 
 865                870                875                880
Ser Val Val Met Asp Arg Ala Pro Val Tyr Ser Phe Phe Thr Gly Glu 
                 885                890                895
Gly Thr Gly Lys Glu Asn Glu Ala Gln Gln Ser Pro Ser Pro Asn Thr 
             900                905                910
Ala Leu Ser Ala Ala Gln Ser Gln Lys Thr Ala Met Tyr Leu Glu Gln 
         915                920                925
Glu Val Ala Pro Leu Thr Pro Ser Val Gly Thr Gly Glu Arg Val Gly 
     930                935                940
Asn Ile Pro Thr Gln Arg Arg His Ser Ala Gln Leu Pro Ser Gly His 
 945                950                955                960
Ile Met Pro Val Met His Ser Ala Arg Asp Leu His Ser Gln Glu Arg 
                 965                970                975
Ser Thr Pro Leu Ser Glu Arg His Ala Gln Glu Ser Thr Gly Glu Gly 
             980                985                990
Asn Ser Leu Thr Ser Asn Ala Ser Ser Gly His Ala Val Ser Ser Leu 
         995                1000                1005
Ala Asp Ala Ala Thr Asp Ser Ser Cys Thr Ser Gly Ala Glu Gln Thr 
     1010                1015                1020
Asp Gly His Ser Ile Arg Lys Lys Arg Arg Ala Thr Gly Asp Gly Ser 
 1025                1030                1035                1040
Ser Pro Glu Leu Pro Ser Leu Glu Arg Lys Asn Lys Arg Arg Lys Ile 
                 1045                1050                1055
Lys Gly Lys Lys Glu Arg Ser Gln Val Asp Gln Leu Leu Thr Ile Ser 
             1060                1065                1070
Leu Arg Glu Glu Glu Leu Ser Lys Ser Leu Gln Cys Met Asp Asn Lys 
         1075                1080                1085
Leu Leu Gln Ala Arg Ala Ala Leu Gln Thr Ala Tyr Val Glu Val Gln 
     1090                1095                1100
Arg Leu Leu Val Leu Lys Gln Gln Ile Thr Val Glu Met Ser Ala Leu 
 1105                1110                1115                1120
Arg Thr His Arg Ile Gln Ile Leu Gln Gly Leu Gln Glu Thr Tyr Glu 
                 1125                1130                1135
Pro Pro Glu His Pro Asp Gln Ala Pro Cys Ser Leu Ile Ser Arg Glu 
             1140                1145                1150
Gln Arg Asn Ser Arg Ser Gln Thr Ser Phe Glu Thr Ala Leu Leu Pro 
         1155                1160                1165
Ala Pro Phe Phe Pro Gly Phe Leu Asp Pro Pro Pro Ser His Ala Ser 
     1170                1175                1180
Leu Pro Ser Ser Gly Asn Pro Leu Gln Ile Thr Thr Cys Thr Leu Gln 
 1185                1190                1195                1200
Ala His Gly Thr Ala Pro Asp Ser Ser Val Gln Ile Lys Gln Glu Pro 
                 1205                1210                1215
Met Ser Pro Glu Gln Glu Gly Asn Met Asn Ala Leu Pro Gln Gly Cys 
             1220                1225                1230
Ala Ser Asn Val Ser Lys Glu Leu Leu Gln Thr Asn Arg Val Val Asp 
         1235                1240                1245
Asp Gly Ser Ser Val Tyr Pro Ala Ile Pro Ala Val Ile Ala Pro Glu 
     1250                1255                1260
Ser Thr Glu Asn Cys Gln Glu Val Ser Lys Asp Leu Asn Phe Ser Val 
 1265                1270                1275                1280
Glu Gln Gly Asn Ser Arg Ser Lys Gly Asn Ser Pro Ser Cys Gln Ser 
                 1285                1290                1295
Pro Asp Leu Pro Gly Ile Asn Arg Gly Glu Glu Thr Ala Lys Gly Ser 
             1300                1305                1310
Ser Gly Ser Glu Ala Cys Ser Ser Ser Phe Leu Arg Leu Ser Phe Thr 
         1315                1320                1325
Pro Glu Thr Pro Ala Glu Lys Glu Thr Gln Ser Pro Ala Asp Gln Pro 
     1330                1335                1340
Glu Gln Gln Ala Glu Ser Thr Leu Ala Ser Ala Glu Thr Arg Gly Ser 
 1345                1350                1355                1360
Lys Lys Lys Lys Lys Leu Arg Lys Lys Lys Thr Leu Arg Ala Thr His 
                 1365                1370                1375
Val Pro Glu Asn Ser Asp Thr Glu Gln Asp Val Phe Thr Ala Lys Pro 
             1380                1385                1390
Ala Arg Lys Val Lys Thr Ala Lys Ala Ala Lys Gly Ala Lys Val Thr 
         1395                1400                1405
Thr Ser Gln Thr Gly Gln Glu Gln Gly Thr Ala Arg Asp Glu Pro Asp 
     1410                1415                1420
Ser Asp Ser Ser Leu Glu Val Leu Glu Val Thr Asn Pro Gln Leu Glu 
 1425                1430                1435                1440
Val Val Ala Ile Asp Thr Ser Glu Ser Gly Asp Glu Lys Pro Asp Ser 
                 1445                1450                1455
Pro Ser Lys Lys Asp Ala Trp Ile Ala Ala Glu Gln Asn Pro Ile Glu 
             1460                1465                1470
Thr Ser Arg Ser Gly Cys Asp Glu Val Ser Ser Thr Ser Glu Leu Gly 
         1475                1480                1485
Thr Arg Tyr Lys Asp Gly Val Pro Val Ser Val Ala Glu Thr Gln Thr 
     1490                1495                1500
Val Ile Ser Ile Lys Ala Ser Lys His Ser Ser Glu Ile Ser Ser Glu 
 1505                1510                1515                1520
Pro Gly Asp Asp Glu Glu Pro Thr Glu Gly Ser Phe Glu Gly His Gln 
                 1525                1530                1535
Ala Ala Val Asn Ala Ile Gln Ile Phe Gly Asn Phe Leu Tyr Thr Cys 
             1540                1545                1550
Ser Ala Asp Thr Thr Val Arg Val Tyr Asn Leu Val Ser Arg Lys Cys 
         1555                1560                1565
Val Gly Val Phe Glu Gly His Thr Ser Lys Val Asn Cys Leu Leu Val 
     1570                1575                1580
Thr His Thr Ser Gly Lys Ser Ser Val Leu Tyr Thr Gly Ser Ser Asp 
 1585                1590                1595                1600
His Thr Ile Arg Cys Tyr Asn Ile Lys Thr Arg Glu Cys Met Glu Gln 
                 1605                1610                1615
Leu Gln Leu Glu Asp Arg Val Leu Cys Leu His Asn Arg Trp Arg Thr 
             1620                1625                1630
Leu Tyr Ala Gly Leu Ala Asn Gly Thr Val Val Thr Phe Asp Ile Lys 
         1635                1640                1645
Asn Asn Lys Arg Gln Glu Ile Phe Glu Cys His Gly Pro Arg Ala Val 
     1650                1655                1660
Ser Cys Leu Ala Thr Ala Gln Glu Gly Ala Arg Lys Leu Leu Val Val 
 1665                1670                1675                1680
Gly Ser Tyr Asp Cys Thr Ile Ser Val Arg Asp Ala Arg Asn Gly Leu 
                 1685                1690                1695
Leu Leu Arg Thr Leu Glu Gly His Ser Lys Thr Val Leu Cys Met Lys 
             1700                1705                1710
Val Val Asn Asp Leu Val Phe Ser Gly Ser Ser Asp Gln Ser Val His 
         1715                1720                1725
Ala His Asn Ile His Thr Gly Glu Leu Val Arg Ile Tyr Lys Gly His 
     1730                1735                1740
Asn His Ala Val Thr Val Val Asn Ile Leu Gly Lys Val Met Val Thr 
 1745                1750                1755                1760
Ala Cys Leu Asp Lys Phe Val Arg Val Tyr Glu Leu Gln Ser His Asp 
                 1765                1770                1775
Arg Leu Gln Val Tyr Gly Gly His Lys Asp Met Ile Met Cys Met Thr 
             1780                1785                1790
Ile His Lys Ser Val Ile Tyr Thr Gly Cys Tyr Asp Gly Ser Ile Gln 
         1795                1800                1805
Ala Val Arg Leu Asn Leu Met Gln Asn Tyr Arg Cys Trp Trp Tyr Gly 
     1810                1815                1820
Cys Thr Leu Ile Phe Gly Val Val Asp His Leu Lys Gln His Leu Leu 
 1825                1830                1835                1840
Thr Asp His Thr Asn Pro Asn Phe Gln Thr Leu Lys Cys Arg Trp Arg 
                 1845                1850                1855
Asn Cys Asp Ala Phe Phe Thr Ala Arg Lys Gly Ser Lys Gln Asp Val 
             1860                1865                1870
Ala Gly His Ile Glu Arg His Ala Glu Asp Asp Ser Lys Ile Asp Ser 
         1875                1880                1885



<210> 7331
<211> 514
<212> DNA
<213> Rattus norvegicus
<308> AI638997
<400> 7331

ttaaaatta  tcaaagaca  gtttttatt  caaatattt  ctcaaaaac  actatatac  60
acagaattt  aacaggcct  gaaaacatt  aacattcaa  taaacagtt  caaagaatt  120
aaagtacat  ttaagaatt  aaaatgcag  atttaaaat  aaactttat  agtacttaa  180
agcaaatta  tgttatatt  acttctata  ctaaaaaaa  caacttagt  gctgactta  240
ggataaatt  ggctaattc  caccccccc  cttgttttt  aacatatgc  ttagggtcc  300
attagaagt  tctactttt  caattgagg  cgtccctta  catagttga  tacatgcga  360
ggcatgttt  tagttcaat  ccttttgcc  acattctac  atactttgg  ttggtttcc  420
gaccatttt  atgggtcta  tgctaaaaa  cattgaaac  atattaaaa  catagtagc  480
atttaagag  ttcaataac  gatttctac  ttat  514



<210> 7332
<211> 4902
<212> DNA
<213> Homo sapiens
<308> XM_046094
<400> 7332

gacctcgac  gggaacgca  gcaaaacca  acatttaaa  cagacttgg  aaaatcagc  60
cgttattta  agaaacgga  gattccttt  tctctcctg  tttagtctt  gacccacag  120
ccccttgct  ctttcgaac  gcggctgta  cccatgacc  tttcacttt  caagccaac  180
gactggggg  cgttacaca  gcggagggc  cggaacgca  ggctcctcg  ctgcaaatt  240
cgagcagtc  ggattttgg  gctgcctcc  ggccacacc  gccagcagc  cgcacccac  300
tggaggcag  gccctggcc  tcgccccgg  ccggcgcgt  gcggggcgc  tgggtcttc  360
agggcccgc  acgcggcgc  catgccggt  cccgcctcc  gcgtcggcg  gaagacagg  420
agctcggac  cggggaggc  gacccggag  ctacccatg  ggcagcgcg  cggctgcac  480
agagccccc  cctttccac  gctcggctg  cagctccgc  atgggagcc  ccgccgtcg  540
cgcagtgta  tttttcgtg  tcctccttt  cctcctcct  tttctcctc  tcctcaggg  600
tccagtcag  ccgatccgc  ccgctcacg  aaggaaaac  gaaataact  gctggcttg  660
ctggagtca  atggtaatt  aaaaatggc  gaactgttt  tggaatgtg  agaagagga  720
ctggaacca  ggcagaaga  agtaaaaga  gttgaggat  acgatgatg  tgagccaat  780
tttgttggc  agatatcaa  ttcaaaacc  gcaatttca  atattttga  cagagttaa  840
cccagctca  attcaaggg  actaaagaa  ggtgcactc  gtcgaggta  tactgctgc  900
ttcaagcct  caagtcaac  ctacacgaa  ccaacatca  atccagtgc  tgcctcacc  960
ataaatttt  atcctgagt  tagatcttc  gatagttct  ttattgttc  gcctttttc  1020
aaacctggt  atataacaa  ctcatcacg  gttgtgtct  ataagtcat  agagttact  1080
tttgacttg  cccaggata  aggattatc  cattaccaa  ggggaccaa  actttctat  1140
gcaggtatg  gtgaaagtt  atttttatc  aaacgtcct  ctacttctg  agtaaataa  1200
gttaatcca  agaagccta  acccagcga  agtgtttct  gagcaaatt  ctcagctgt  1260
ttaccttca  ttaaatctc  ttcagtgac  tcttcccag  ctatgctag  aaaaggtac  1320
aatacctca  caaatcagt  taaaaatgg  acacctttt  caagagctt  tccaaagtg  1380
aacattcat  tcaatcttt  ggatccttt  aaaaatcac  tgaagtatt  ttgtccaga  1440
atgataaat  actttttgg  actggctaa  acagaattt  caagtacag  aaataaaaa  1500
acaactatt  attcagaga  aggaaaatt  atcatgtta  ttaatgact  ttattatgg  1560
aaacatgaa  gagatgtcc  ggaggaaca  aagactcac  caaccttta  atgcttcag  1620
tgcttgaaa  ttctaaaaa  taacattag  tttatgaac  acatgaaac  ccatttgga  1680
cttgagaag  agagcagtg  gagctggga  aaccatacc  cctgccagc  ctgctaccg  1740
cagtttccc  caccatttc  gttgcagtg  cacatcgaa  gtacacata  gccccatga  1800
ttttctact  tttgtaaaa  ctgtgaatt  tcatttgaa  cagaacatg  tcttttaca  1860
catatgaag  acaatcata  acctggtga  atgccatat  tctgccagg  ttgtaatta  1920
agatcatca  cattttctg  tgtagaaac  cattttaga  catcccatg  aaacactaa  1980
aacttgcta  gcccgtttt  cctcaaagt  attaaaatt  caacaccat  tatgcatca  2040
tatatgaag  atcagaaaa  aggaataca  cgttgtaca  aatgcaggc  gcagttttt  2100
acatgcaag  agaaaatgg  tcataagac  caacaccat  gaacattta  aaaacctaa  2160
caactagaa  gattgcctc  tggaacaaa  gttactatt  gagcttcag  tggacctct  2220
caatcagga  cttcaccta  accttccat  agtgcaagt  cttctaccc  tcagctctc  2280
cctccaagg  ctaaaaata  aactgctaa  aatcctgca  aatctaata  aagtaaacc  2340
aatacagtc  aatccaacg  aagtaaacc  aatacaagt  agcctaatg  aagtaaatc  2400
aaatacaaa  caaaaatct  taatatgca  aagaaacaa  gcacattgg  tagtagcaa  2460
aaaaaaagt  aagtcaata  agcattgag  aatttaagg  atcgtcggg  cattcacaa  2520
tgcattgag  gttgttccg  aataaaaga  tttgcaaac  actttccta  gtacgtcca  2580
tgtagtttt  gcagataca  cactagctg  agcaaagcc  atgtaaatc  tatgatgag  2640
tttcatagt  accgtccaa  caaaaggtt  tgtattttt  agaagcatt  agaaaatct  2700
cggggcatt  ctctagtgt  ccttaattg  gatttccta  gtgatgttt  tggcttaga  2760
aatatggct  cacacttaa  tcaacataa  actcatact  gccaagttg  aatgcagaa  2820
gtttctgtt  gtatcccaa  ttctgagca  ctttctgaa  taaaaaaag  agctcccgc  2880
aaggaacaa  aacctgtgt  taaggaaat  gcaagacct  acatggctg  aagagaaac  2940
gaaacatca  attctgaaa  taaacaaga  aaagctgct  cttcaaaag  aaaaaatgg  3000
tgtaatgca  attcatttg  aggctcatc  acaacaaaa  gtgaagaaa  cataacagt  3060
tcagataag  aaaatgaaa  ctgtcttgc  gaccaggaa  ctggctcaa  aaacatcgt  3120
agttgtgat  caaatattg  tgcagataa  gtggaaaag  aaaaacaaa  acaacacgt  3180
tgtcaggaa  tggagttga  gatgtgcca  agttcagaa  acataatct  atctgatca  3240
attaaagat  acaactcca  tgaagccag  ttttcttca  agaatatta  ggatttgcg  3300
ttagcatca  ataatgtaa  cattgatca  tttttgaga  aaagacatg  acctgaatc  3360
gttagttct  atgttagcg  gcaaggcag  attcatttg  aacctctga  tccatccga  3420
gtacttgag  atgaagcca  agagattct  cagaaaggt  gtggtgatc  ttcagccaa  3480
actgatgaa  tagtgtctg  tcaaacaga  gacattcct  gaggaaata  ccctagcac  3540
acagaggca  cagtagacc  ggaagacga  aaagaaaga  gttgaaatt  gtcatttta  3600
gtttcagtg  accaacgat  agggcattt  gaacagtgc  atcaggtga  ctcagtggt  3660
ctgttgtag  ttcagaaat  gaaatatgt  agggaggtc  cacatacac  ttacctgta  3720
gttcaacct  tgttatcaa  caaatcaat  caccaataa  agcatgatt  gtagggatt  3780
ccaaaaagt  tttaaaaac  cgaacagga  tttaatgat  attaaattt  cagtggaaa  3840
gtctcattt  atggttttc  aggaaatgg  atttggttg  tgacatgaa  tgatgatat  3900
agtaatatt  ataaagcct  tcaaacttc  atcaatcct  agctaaaaa  ctttattac  3960
tgtatatcc  tttcagtta  ctgagagga  gggatttgg  aaccatgta  ttttgggga  4020
taattgatt  aaaacaatg  ctgattggc  ttgttaatg  aggctttat  tgtgaggat  4080
atgctggta  atggagcat  cttagagta  taaattgat  taatgagaa  ttggatgaa  4140
ataaactta  ttttggatt  aatataaca  tccagtcag  cgcatgtaa  cagaatatt  4200
gaatctttg  acctccata  aagtgttag  ctgccaggc  gtaagctta  cttaattaa  4260
ctttcagtg  aagtggaat  attaagata  aaatttata  ttgtgcttt  tgtcagtgt  4320
taagctgtg  agaaattct  tgatgtatt  gttgtatta  tgtaaagta  aaacccatt  4380
ttgaaactc  tgtagctat  atgctttta  tattgtttt  atgatcttc  ttagaaata  4440
gcccataaa  atggtctgg  agccaaacc  aagtatggt  taatgtaga  attgtaaag  4500
agtaaactg  aaacatgtc  tggcatgta  tcagccatg  ttaagtgac  tttctgtaa  4560
tgtaaaata  aaacttcaa  tgggaccta  aacagtgat  taaaagaac  ggttttgga  4620
atttagcct  atttatcta  aagatggct  ctaaattga  ttttcagtt  tttttatca  4680
ctagaatat  atagatata  aaatgaata  tatgaagaa  agtagtttg  tttgaaata  4740
taataaact  ttatttaaa  tgcttcatt  ttacttctt  aaatgtgct  tggattctt  4800
aattttgtt  cactgaatg  tcaatgttt  aaatggcga  taaaatact  tgctgtata  4860
agtagtttt  gagtaaata  ttgcaataa  aatctgccc  cg  4902



<210> 7333
<211> 1143
<212> PRT
<213> Homo sapiens
<308> XP_046094
<400> 7333

Met Thr Phe Ser Leu Ser Lys Pro Thr Asp Trp Gly Ser Leu His Thr 
  1               5                  10                  15
Arg Arg Ala Arg Asn Ala Arg Leu Leu Ala Cys Lys Phe Arg Ala Val 
             20                  25                  30
Arg Ile Leu Gly Leu Pro Pro Gly His Thr Ser Gln Gln Leu Ala Pro 
         35                  40                  45
Thr Trp Arg Gln Gly Pro Gly Pro Arg Pro Gly Pro Ala Arg Gly Gly 
     50                  55                  60
Ala Arg Gly Ser Ser Arg Ala Arg Asp Ala Ala His Met Pro Val Pro 
 65                  70                  75                  80
Ala Ser Arg Val Gly Glu Lys Thr Gly Ser Ser Asp Thr Gly Arg Leu 
                 85                  90                  95
Thr Arg Ser Leu Pro Met Arg Gln Arg Ala Gly Cys Thr Arg Ala Pro 
             100                105                110
Pro Phe Pro Arg Leu Gly Cys Gln Leu Arg Asn Gly Ser Arg Arg Arg 
         115                120                125
Arg Arg Ser Val Val Phe Arg Ala Pro Pro Phe Pro Pro Pro Leu Ser 
     130                135                140
Pro Pro Pro Gln Gly Ser Ser Gln Ala Asp Pro Leu Arg Ser Arg Lys 
 145                150                155                160
Glu Asn Arg Asn Asn Leu Leu Ala Cys Leu Glu Ser His Gly Asn Ser 
                 165                170                175
Lys Met Ala Glu Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu Pro 
             180                185                190
Trp Gln Lys Lys Val Lys Glu Val Glu Asp Asp Asp Asp Asp Glu Pro 
         195                200                205
Ile Phe Val Gly Glu Ile Ser Ser Ser Lys Pro Ala Ile Ser Asn Ile 
     210                215                220
Leu Asn Arg Val Asn Pro Ser Ser Tyr Ser Arg Gly Leu Lys Asn Gly 
 225                230                235                240
Ala Leu Ser Arg Gly Ile Thr Ala Ala Phe Lys Pro Thr Ser Gln His 
                 245                250                255
Tyr Thr Asn Pro Thr Ser Asn Pro Val Pro Ala Ser Pro Ile Asn Phe 
             260                265                270
His Pro Glu Ser Arg Ser Ser Asp Ser Ser Val Ile Val Gln Pro Phe 
         275                280                285
Ser Lys Pro Gly Tyr Ile Thr Asn Ser Ser Arg Val Val Ser Asn Lys 
     290                295                300
Ser Ser Glu Leu Leu Phe Asp Leu Thr Gln Asp Thr Gly Leu Ser His 
 305                310                315                320
Tyr Gln Gly Gly Pro Thr Leu Ser Met Ala Gly Met Ser Glu Ser Ser 
                 325                330                335
Phe Leu Ser Lys Arg Pro Ser Thr Ser Glu Val Asn Asn Val Asn Pro 
             340                345                350
Lys Lys Pro Lys Pro Ser Glu Ser Val Ser Gly Ala Asn Ser Ser Ala 
         355                360                365
Val Leu Pro Ser Val Lys Ser Pro Ser Val Thr Ser Ser Gln Ala Met 
     370                375                380
Leu Ala Lys Gly Thr Asn Thr Ser Ser Asn Gln Ser Lys Asn Gly Thr 
 385                390                395                400
Pro Phe Pro Arg Ala Cys Pro Lys Cys Asn Ile His Phe Asn Leu Leu 
                 405                410                415
Asp Pro Leu Lys Asn His Met Lys Tyr Cys Cys Pro Asp Met Ile Asn 
             420                425                430
Asn Phe Leu Gly Leu Ala Lys Thr Glu Phe Ser Ser Thr Val Asn Lys 
         435                440                445
Asn Thr Thr Ile Asp Ser Glu Lys Gly Lys Leu Ile Met Leu Val Asn 
     450                455                460
Asp Phe Tyr Tyr Gly Lys His Glu Gly Asp Val Gln Glu Glu Gln Lys 
 465                470                475                480
Thr His Thr Thr Phe Lys Cys Phe Ser Cys Leu Lys Ile Leu Lys Asn 
                 485                490                495
Asn Ile Arg Phe Met Asn His Met Lys His His Leu Glu Leu Glu Lys 
             500                505                510
Gln Ser Ser Glu Ser Trp Glu Asn His Thr Thr Cys Gln His Cys Tyr 
         515                520                525
Arg Gln Phe Pro Thr Pro Phe Gln Leu Gln Cys His Ile Glu Ser Thr 
     530                535                540
His Thr Pro His Glu Phe Ser Thr Ile Cys Lys Ile Cys Glu Leu Ser 
 545                550                555                560
Phe Glu Thr Glu His Val Leu Leu Gln His Met Lys Asp Asn His Lys 
                 565                570                575
Pro Gly Glu Met Pro Tyr Val Cys Gln Val Cys Asn Tyr Arg Ser Ser 
             580                585                590
Ser Phe Ser Asp Val Glu Thr His Phe Arg Thr Ser His Glu Asn Thr 
         595                600                605
Lys Asn Leu Leu Cys Pro Phe Cys Leu Lys Val Ile Lys Ile Ala Thr 
     610                615                620
Pro Tyr Met His His Tyr Met Lys His Gln Lys Lys Gly Ile His Arg 
 625                630                635                640
Cys Thr Lys Cys Arg Leu Gln Phe Leu Thr Cys Lys Glu Lys Met Asp 
                 645                650                655
His Lys Thr Gln His His Arg Thr Phe Ile Lys Pro Lys Gln Leu Glu 
             660                665                670
Gly Leu Pro Pro Gly Thr Lys Val Thr Ile Arg Ala Ser Val Gly Pro 
         675                680                685
Leu Gln Ser Gly Ala Ser Pro Thr Pro Ser Ile Ser Ala Ser Ala Ser 
     690                695                700
Thr Leu Gln Leu Ser Pro Pro Arg Thr Lys Asn Ile Thr Ala Lys Asn 
 705                710                715                720
Pro Ala Lys Ser Asn Thr Ser Lys Pro Asn Thr Val Lys Ser Asn Ala 
                 725                730                735
Ser Lys Pro Asn Thr Ser Lys Pro Asn Gly Ser Lys Ser Lys Tyr Lys 
             740                745                750
Pro Lys Ile Ser Asn Met Gln Lys Lys Gln Ser Thr Leu Ala Ser Ser 
         755                760                765
Asn Lys Lys Ser Lys Val Asn Thr Ala Leu Arg Asn Leu Arg Tyr Arg 
     770                775                780
Arg Gly Ile His Lys Cys Ile Glu Cys Cys Ser Glu Ile Lys Asp Phe 
 785                790                795                800
Ala Asn His Phe Pro Thr Tyr Val His Cys Ser Phe Cys Arg Tyr Asn 
                 805                810                815
Thr Ser Cys Ser Lys Ala Tyr Val Asn His Met Met Ser Phe His Ser 
             820                825                830
Asn Arg Pro Ser Lys Arg Phe Cys Ile Phe Lys Lys His Ser Glu Asn 
         835                840                845
Leu Arg Gly Ile Thr Leu Val Cys Leu Asn Cys Asp Phe Leu Ser Asp 
     850                855                860
Val Ser Gly Leu Asp Asn Met Ala Thr His Leu Ser Gln His Lys Thr 
 865                870                875                880
His Thr Cys Gln Val Val Met Gln Lys Val Ser Val Cys Ile Pro Thr 
                 885                890                895
Ser Glu His Leu Ser Glu Leu Lys Lys Glu Ala Pro Ala Lys Glu Gln 
             900                905                910
Glu Pro Val Ser Lys Glu Ile Ala Arg Pro Asn Met Ala Glu Arg Glu 
         915                920                925
Thr Glu Thr Ser Asn Ser Glu Ser Lys Gln Asp Lys Ala Ala Ser Ser 
     930                935                940
Lys Glu Lys Asn Gly Cys Asn Ala Asn Ser Phe Glu Gly Ser Ser Thr 
 945                950                955                960
Thr Lys Ser Glu Glu Ser Ile Thr Val Ser Asp Lys Glu Asn Glu Thr 
                 965                970                975
Cys Leu Ala Asp Gln Glu Thr Gly Ser Lys Asn Ile Val Ser Cys Asp 
             980                985                990
Ser Asn Ile Gly Ala Asp Lys Val Glu Lys Lys Lys Gln Ile Gln His 
         995                1000                1005
Val Cys Gln Glu Met Glu Leu Lys Met Cys Gln Ser Ser Glu Asn Ile 
     1010                1015                1020
Ile Leu Ser Asp Gln Ile Lys Asp His Asn Ser Ser Glu Ala Arg Phe 
 1025                1030                1035                1040
Ser Ser Lys Asn Ile Lys Asp Leu Arg Leu Ala Ser Asp Asn Val Ser 
                 1045                1050                1055
Ile Asp Gln Phe Leu Arg Lys Arg His Glu Pro Glu Ser Val Ser Ser 
             1060                1065                1070
Asp Val Ser Glu Gln Gly Ser Ile His Leu Glu Pro Leu Thr Pro Ser 
         1075                1080                1085
Glu Val Leu Glu Tyr Glu Ala Thr Glu Ile Leu Gln Lys Gly Ser Gly 
     1090                1095                1100
Asp Pro Ser Ala Lys Thr Asp Glu Val Val Ser Asp Gln Thr Asp Asp 
 1105                1110                1115                1120
Ile Pro Gly Gly Asn Asn Pro Ser Thr Thr Glu Ala Thr Val Asp Leu 
                 1125                1130                1135
Glu Asp Glu Lys Glu Arg Ser 
             1140



<210> 7334
<211> 333
<212> DNA
<213> Rattus norvegicus
<308> AI639001
<400> 7334

ttcaaggat  ataatgtat  gagttgaga  ttcacaaaa  ggtaacatc  tacaatcag  60
catttcttg  gctgagtaa  aatgattgt  acccactgt  cgtcacaaa  aattctttt  120
atgaataaa  aatttgatg  aatcaaaaa  atttacaat  taaacaaat  gaaaagctt  180
ggatctgtg  ctgaccagg  tacatttcg  atggaggcc  ccccagctt  tctcttaga  240
cccatataa  tccgctaga  acaacaact  atacaatgt  tctctgttc  ttacatctt  300
atctgttag  ctttgaaag  tatataatc  tat  333



<210> 7335
<211> 333
<212> DNA
<213> Rattus norvegicus
<308> AI639001
<400> 7335

ttcaaggat  ataatgtat  gagttgaga  ttcacaaaa  ggtaacatc  tacaatcag  60
catttcttg  gctgagtaa  aatgattgt  acccactgt  cgtcacaaa  aattctttt  120
atgaataaa  aatttgatg  aatcaaaaa  atttacaat  taaacaaat  gaaaagctt  180
ggatctgtg  ctgaccagg  tacatttcg  atggaggcc  ccccagctt  tctcttaga  240
cccatataa  tccgctaga  acaacaact  atacaatgt  tctctgttc  ttacatctt  300
atctgttag  ctttgaaag  tatataatc  tat  333



<210> 7336
<211> 419
<212> DNA
<213> Rattus norvegicus
<308> AI639002
<400> 7336

ttggaaaag  ggagtttaa  aactttttt  taaaacccc  aaggggaag  actttgcag  60
gggggggcc  ctgattccc  aaaaggccc  ggccataag  gtggaaaaa  aaaaacttg  120
aaaaaggac  cctgcaaaa  aaaagggtt  agggttttt  ttgaaggga  ccttttggt  180
ttttaattt  aagcccccc  caattttgc  tttggttgg  gaaccgcct  ttttgttaa  240
tttggccaa  atttccatt  tggccggaa  agtaaaaaa  tggtttttt  aacgttaaa  300
tttttccca  aaaaaaaat  tggaagccc  cattgggaa  caaggttcc  aaagttctt  360
ggccttgcc  ctaagttta  aaacacaaa  aggggaaat  ttaaaaggt  cgccccttt  419



<210> 7337
<211> 537
<212> DNA
<213> Rattus norvegicus
<308> AI639019
<400> 7337

ttcaaagtc  cttctctta  tgctttatt  taaattagc  gcagatgat  cagatcata  60
tgtaccgag  acacacgaa  ccggcagcc  tgatgacgc  gctcagcac  tgctgatct  120
cccggcttc  tgggagcat  gcccactcc  gagggaacc  ctatgtagg  cagcacact  180
tcgttcatc  ctgagtgtt  tcatagaca  acagaactg  aatggccct  cctctccct  240
caggggtca  tgggagtct  tcaatcatt  tgtgtgctt  ggccccacg  tgactgtcc  300
ctgtggctg  gatgacagt  ggtcgcttg  cactctgag  gtgtcagct  tctcttctt  360
atttaagtc  tcttgccat  ggtggggat  gccaacttg  gtgaccttt  gccacaggc  420
acctctgta  gttcctctg  cattttgct  gttcattta  ttttgtttt  ctggaaatt  480
aaagtttga  tcctttgtc  gttatagac  ctttgtgaa  gtaactgcc  ccggcgg  537



<210> 7339
<211> 769
<212> PRT
<213> Rattus norvegicus
<308> AAC60679
<400> 7339

Met Leu Ser Ser Val Cys Val Trp Ser Phe Arg Gly Cys Gln Gly Thr 
  1               5                  10                  15
Gly Lys Gln Gln Pro Gln Pro Val Pro Thr Pro Gln Pro Pro Glu Ser 
             20                  25                  30
Ser Pro Pro Pro Leu Pro Pro Pro Gln Gln Gln Gln Cys Ser Gln Pro 
         35                  40                  45
Gly Thr Gly Pro Ser Pro Gly Val Pro Ala Phe Leu Arg Pro Gly Gly 
     50                  55                  60
Arg Arg Ala Glu Pro Cys Pro Gly Leu Pro Ala Val Ala Met Gly Arg 
 65                  70                  75                  80
His Gly Gly Gly Gly Gly Asp Ser Gly Lys Ile Val Ile Asn Val Gly 
                 85                  90                  95
Gly Val Arg His Glu Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly 
             100                105                110
Thr Arg Leu Ala Gly Leu Thr Glu Pro Glu Ala Ala Ala Arg Phe Asp 
         115                120                125
Tyr Asp Pro Gly Thr Asp Glu Phe Phe Phe Asp Arg His Pro Gly Val 
     130                135                140
Phe Ala Tyr Val Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro 
 145                150                155                160
Ala Asp Val Cys Gly Pro Leu Phe Glu Glu Glu Leu Gly Phe Trp Gly 
                 165                170                175
Ile Asp Glu Thr Asp Val Glu Ala Cys Cys Trp Met Thr Tyr Arg Gln 
             180                185                190
His Arg Asp Ala Glu Glu Ala Leu Asp Ser Phe Glu Ala Pro Asp Ser 
         195                200                205
Ser Ala Asn Ala Asn Ala Asn Ala Gly Gly Ala His Asp Ala Gly Leu 
     210                215                220
Asp Asp Glu Ala Gly Ala Gly Gly Gly Gly Leu Asp Gly Ala Gly Gly 
 225                230                235                240
Glu Leu Lys Arg Leu Cys Phe Gln Asp Ala Gly Gly Gly Ala Gly Gly 
                 245                250                255
Leu Pro Gly Gly Ala Gly Gly Ala Gly Gly Thr Trp Trp Arg Arg Trp 
             260                265                270
Gln Pro Arg Val Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Ala 
         275                280                285
Ala Arg Tyr Val Ala Phe Ala Ser Leu Phe Phe Ile Leu Ile Ser Ile 
     290                295                300
Thr Thr Phe Cys Leu Glu Thr His Glu Gly Phe Ile His Ile Ser Asn 
 305                310                315                320
Lys Thr Val Thr Gln Ala Ser Pro Ile Pro Gly Ala Pro Pro Glu Asn 
                 325                330                335
Ile Thr Asn Val Glu Val Glu Thr Glu Pro Phe Leu Thr Tyr Val Glu 
             340                345                350
Gly Val Cys Val Val Trp Phe Thr Phe Glu Phe Leu Met Arg Val Thr 
         355                360                365
Phe Cys Pro Asp Lys Val Glu Phe Leu Lys Ser Ser Leu Asn Ile Ile 
     370                375                380
Asp Cys Val Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly 
 385                390                395                400
Leu Ser Ser Lys Ala Ala Lys Asp Val Leu Gly Phe Leu Arg Val Val 
                 405                410                415
Arg Phe Val Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val 
             420                425                430
Gly Leu Arg Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe 
         435                440                445
Leu Leu Leu Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr 
     450                455                460
Met Ile Tyr Tyr Ala Glu Arg Ile Gly Ala Asp Pro Asp Asp Ile Leu 
 465                470                475                480
Gly Ser Asn His Thr Tyr Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp 
                 485                490                495
Ala Val Val Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Lys 
             500                505                510
Thr Trp Ser Gly Met Leu Val Gly Gly Leu Cys Ala Leu Ala Gly Val 
         515                520                525
Leu Thr Ile Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met 
     530                535                540
Tyr Tyr Ser Leu Ala Met Ala Lys Gln Lys Leu Pro Lys Lys Lys Asn 
 545                550                555                560
Lys His Ile Pro Arg Pro Pro Gln Pro Gly Ser Pro Asn Tyr Cys Lys 
                 565                570                575
Pro Asp Pro Pro Pro Pro Pro Pro Pro His Pro His His Gly Ser Gly 
             580                585                590
Gly Ile Ser Pro Pro Pro Pro Ile Thr Pro Pro Ser Met Gly Val Asn 
         595                600                605
Val Ala Gly Ala Tyr Pro Pro Gly Pro His Thr His Pro Gly Leu Leu 
     610                615                620
Arg Gly Gly Ala Gly Gly Leu Gly Ile Met Gly Leu Pro Pro Leu Pro 
 625                630                635                640
Ala Pro Gly Glu Pro Cys Pro Leu Ala Gln Glu Glu Val Ile Glu Thr 
                 645                650                655
Asn Arg Ala Val Asp Pro Arg Pro Asn Gly Asp Pro Ala Ala Ala Ala 
             660                665                670
Leu Ala His Glu Asp Cys Pro Ala Ile Asp Gln Pro Ala Met Ser Pro 
         675                680                685
Glu Asp Lys Ser Pro Ile Thr Pro Gly Ser Arg Gly Arg Tyr Ser Arg 
     690                695                700
Asp Arg Ala Cys Phe Leu Val Thr Asp Tyr Ala Pro Ser Pro Asp Gly 
 705                710                715                720
Ser Ile Arg Lys Gly Tyr Glu Lys Ser Arg Ser Leu Ser Ser Ile Val 
                 725                730                735
Gly Leu Ser Gly Val Ser Leu Arg Leu Ala Pro Leu Ala Thr Pro Pro 
             740                745                750
Gly Ser Pro Arg Ala Thr Arg Arg Ala Pro Pro Thr Leu Pro Ser Ile 
         755                760                765
Leu 
     770



<210> 7340
<211> 299
<212> DNA
<213> Homo sapiens
<308> AI346263
<400> 7340

ttttttttt  aatgaaaag  aaacgtgga  ttttggggg  agtgagggt  gttgggaag  299



<210> 7341
<211> 332
<212> DNA
<213> Rattus norvegicus
<308> AI639034
<400> 7341

ttaacagag  aaaaaggca  cttgcttta  tcttgggat  taggtgggg  tcaggggca  60
cctgtagca  ccagtgagc  tcaccaagc  tgagaggca  caaacaagt  gcacattta  120
gtgggtcct  ggcatctct  agcccacct  cctttcatt  ggcccaggc  tcccaactc  180
caccagatc  tccctaaac  aggtaaggt  ttctgtgtt  ctcatttgg  ttggcactc  240
ttgctttag  ccactgaga  gagtggctc  gtcccagtt  acatanaat  cttttgcat  300
gatactgag  ccaaaatcc  tgtgatctc  ct  332



<210> 7342
<211> 498
<212> DNA
<213> Rattus norvegicus
<308> AI639076
<400> 7342

ttcggagct  gggaccgaa  ccagggcct  gcacatgct  ggcaagcgc  ctaccactg  60
gctaaatcc  caacccctc  tggtctcat  tttatggaa  aaaaattca  attttatga  120
cagctaaaa  atacctgct  atatgcact  atatattat  atatgtgag  tttatatat  180
tacatataa  taattatat  tcatttacc  gcatatatg  atgcttgcg  gatttttat  240
tatattaca  ataatacat  ttatatatg  tgtatatcc  tacataata  aatatatga  300
ttgtatata  ttatataca  atatataaa  tatataaaa  atataatat  gttatatta  360
attttatgt  aatataatt  atataatat  aaattaagt  taaatacat  acatataaa  420
ataaaaatt  catataaat  tataaatat  aatagatat  ttctatatt  tcctcctct  480
tttaagttt  tgaggttt  498



<210> 7343
<211> 267
<212> DNA
<213> Rattus norvegicus
<308> AI639079
<400> 7343

ttaaaaatt  tcccattgc  aaaaacttt  ttttaaggt  tttgaaaat  aggaaagga  60
agtcatgtc  aaatttcaa  tttccaggg  ccgccccga  ggactggtt  tccctgaaa  120
tgcccctgg  cctccccaa  gggggatgt  ctccaggct  tgctggccc  ctgaggaaa  180
ggcccaaac  ttccccccc  ttgttgggg  acatgtcct  gggcaactt  cccctcctt  240
acaataaaa  acctgggga  tcaaccc  267



<210> 7344
<211> 460
<212> DNA
<213> Rattus norvegicus
<308> AI639088
<400> 7344

ttagaggaa  tactttttt  ttaaaatgt  tttttgtat  atatatttg  attacagtt  60
cccctcacc  accccctat  tcacccctc  aaatccaca  ccatttatt  atcttacat  120
agaatagaa  caggcatct  aaatgaagg  gaggaggag  agaagaaga  gtaaaaatg  180
gcaaagcat  acaggaaaa  aagagccca  gaaaatcac  agaaactca  tcagacact  240
agacactta  aattagaga  caaactata  ataaaaaat  tctgtagcg  gaaaaaagt  300
cccagacaa  gcactgtga  tcacaaaac  ctctagaaa  gccatcacg  tcattgcat  360
ttggccatc  gggctgtgg  gcctgctct  aagggtggt  tatatgtcc  gtgagactc  420
attggagaa  actagtttt  cctttgaca  agtttatcaa  460



<210> 7345
<211> 387
<212> DNA
<213> Rattus norvegicus
<308> AI639097
<400> 7345

ttaaacatc  cagaaaact  tttttaagc  gcatggttc  caatttttg  acccaattt  60
taaaggcga  ctacaaaaa  ctttaacat  aacccgggg  ttaataaat  agaggaagg  120
ttccatcat  ttggaaaaa  atcctaacc  ggaggcttt  tttccctat  tattcgaaa  180
ataagtttc  aaactaacg  gggcacatg  gcgtggggg  ccccccccc  ccccatgtt  240
actcggaag  gttttttac  gggtcaaac  aaacccttt  taaaacgtt  aagccgaaa  300
acaaaacag  aagcccact  ggaaaaagt  tttggttta  aaaaaaaaa  atccctagc  360
aaaaacggg  aaatatttc  cttaggg  387



<210> 7346
<211> 508
<212> DNA
<213> Rattus norvegicus
<308> AI639102
<400> 7346

ttaatcatt  cttaaagca  acgctgagt  attactaac  aggagggat  tttgaatta  60
attcnnnnn  aggaaagct  ctaacctgg  tgagaaaac  tcaaagacc  tacattgac  120
tgaagctgt  tggagccaa  cacagcgga  gccaaagga  tttgctttg  tgtctgcaa  180
ttaagatct  ttttctaaa  catctgaga  ttccaatta  atgtcagcc  aaataaatt  240
ccagatgta  aaaatgtgt  atttgtcct  aaaaaaaaa  actggatgt  agctcaccg  300
cgttttggt  aacagtcaa  aaagtgctt  acagacact  tggactacg  cgaaagaca  360
tatccttgc  cacctgata  agatcagtt  aaaataaaa  acactagag  ggtaggttg  420
tacaaatga  atacaattt  gtggggatt  ataaaatct  aaatgagaa  attatgtaa  480
gactgctta  taaaaaaag  tactttta  508



<210> 7347
<211> 428
<212> DNA
<213> Rattus norvegicus
<308> AI639114
<400> 7347

ttaatggac  taactttgc  gttatttgt  tgatagagt  tacaatatg  cacagatat  60
attttctta  gttttggct  taatcaaaa  gaataatta  attttcttt  acattcact  120
aaatttcaa  ttaagactt  atttttccc  catatcctg  gtttcaagg  tctagatgt  180
agagcttcc  ttttgctgg  gcatggctt  tctgcgtct  aggaagtta  acacttagt  240
atcagtcac  catggaccc  aactggcta  aactctagg  atggtgaga  gcattcatt  300
tctgtcttc  aaagttata  cattgttag  agctggttc  aaatatcat  gctaagttt  360
ccagatctt  acattttag  tgcaattct  tcagcaggg  ggctataaa  tgtgtaaat  420
ccacattt  428



<210> 7348
<211> 383
<212> DNA
<213> Homo sapiens
<308> AI192090
<400> 7348

ttttttttt  actgacgat  acatttatt  acctaactt  gctgttatt  gtatgacag  60
gtttacaat  ggccacaat  accattttc  taagttttg  ttgtgttgg  ggtaaccaa  120
caaaaagaa  aaaggtaat  acattttcc  caatatcca  tcaaatttc  gtttaagac  180
tcattttcc  ctcaaatcc  gtgttctga  gttctggat  taagagctt  cttcttgct  240
gggtaatgg  ttgtctgtg  ctgaggaag  tacacactt  gtcatcagt  acccatgga  300
tctcactgg  gaaaacacc  ggcctggtg  ggagcattc  tcttctgtc  tcctcagtt  360
catcattct  gttagctag  agc  383



<210> 7349
<211> 345
<212> DNA
<213> Rattus norvegicus
<308> AI639118
<400> 7349

ttgtttgag  tactgcaaa  atcttttac  gcatttaat  tacttaatg  acatagaag  60
tgctctgac  gaatggatt  ttattgcca  caagctgtc  cacttgttg  cggaagcac  120
cctggcgat  tcgtacgca  ggaaaaaaa  tgttcagaa  caggatgta  gtctgtgaa  180
aatctagcc  acatttggg  gtgatactc  ctgaagtcc  ggattacac  tgcagacaa  240
ttcagagtt  tgaaaacca  gttttctcc  catcacaac  ctggcaaat  acagaacaa  300
ctttgtaca  aaatggtaa  tgggaggca  accactttg  cggaa  345



<210> 7350
<211> 2130
<212> DNA
<213> Homo sapiens
<308> AK000768
<400> 7350

agaaaatgt  tcgagaaag  tgccttgat  aattacact  gactcaccg  atatgccaa  60
atagaagag  ccatgaacc  ggcatctcc  gctagaaag  tggaagaga  tcttcatct  120
gcagagctc  gcatagaag  cttacagca  aatgaagag  atcatgcag  ggcatttgc  180
tggtggcct  atttattgg  tgaacatgc  gagaaattt  gggctttat  tacagtgga  240
atggacact  cactagagg  tcaaccgca  gactcctgg  atagttttc  tcttttcca  300
ctgcttaat  atttcctcc  aaatgacac  cttttgtgt  atggaaaat  tcacaaaca  360
ttgcaagaa  tctttgtac  cttggttgt  cgctatgtg  atctcatgg  gtcttccat  420
gcccagtca  ttcacagag  ttttgagca  gagacatgg  agcctgtca  caatggctc  480
gcaacatca  aagaccttt  ttggaagct  gatgcactg  aaatgtttg  ctttgatct  540
cactggcca  aacaggaat  tgcccacca  ttagagcaa  gacttaaac  aatggccag  600
gatatgcta  aggcctgtg  caaaagaac  agaactgca  ttgaactca  gctacaaaa  660
gcaagcaaa  caactgact  gcgcattcc  gcttccgtt  gcactatgt  taatgtatt  720
gtcgatgcc  aaaagcaaa  caccaaact  tgtgccctg  atggaggac  agagtttgg  780
agtcaatgg  aacagtacc  ttcaaaaat  gatgatctg  tcgacaaca  tgtaaaaga  840
atcatttca  tgttagttt  aaagtttgt  tcagtgttg  aaggcgtgt  gtctaagct  900
tcaaggtat  atgaaggca  tttcttttc  tccattctg  cattcactg  gaaagcagc  960
gcaaaatat  ttgatgttc  aaaaccagg  atggatctg  cagacacct  tattatgtt  1020
gttcggcaa  accaagata  tcttcgaga  aaggtcaat  aggaaatgt  tatagaaaa  1080
ttatttgat  aatggtaca  cagttccat  aaagtcatt  gcgtgtggt  gactgatag  1140
ttagacctc  aactccata  ttaccagct  aagacgctc  tcaagattg  gaagaaaac  1200
tacagggac  ttcgattgc  gggtgtgtt  gaaggaaca  tgaacagta  gacttatga  1260
actgtgcac  gacgtttaa  agtagagga  gccacagcc  ctgtttcag  aggaggagg  1320
cttcagggc  ttactatga  agacagtga  gaagaagaa  aaggctgat  tcacacagc  1380
ttgcagaag  aaggaagac  ttgatcgac  ttgtttttt  tttttttaa  cttgtcctt  1440
taattacat  cattgtttg  tttggccaa  taaaaatgc  tgtatttct  taaaaagta  1500
gcctgaatg  agagtaaaa  gggaaatgc  aagattttg  ggttttttt  tttcctttt  1560
ttgtttgtt  gtttgtttt  ttggagaag  gcatcctct  ttgtgtagt  tgacctaaa  1620
atgaacctt  gctctgctt  tgatcagaa  atgaacttt  ttttttaaa  aagatttga  1680
catttttct  taatcacat  aaaatgatg  tttctgtgt  aagcgagat  catatttct  1740
ataatgcag  attgtgaga  gtcagctcg  accactgca  caacactgt  gtatccttg  1800
taaaatggt  tgtacctta  aaattataa  ttatgtgcc  ggttcgttt  gtacttaat  1860
tgctattat  gtgatgtgt  taaaatctt  aatcttggt  cttagtact  tgaattggt  1920
tacaggtat  ttcctggga  gaaaggatt  ccaaaccca  atatagact  gattatcca  1980
tgggtttgt  tctttgttc  attctcaac  tttcttctt  caactataa  taatcccca  2040
gtgtggggt  gcaagtgtg  ttccgtcaa  ataccatat  ctcctgctc  agtataaca  2100
cttgcaggc  ataaaaatc  atttgctcat  2130



<210> 7351
<211> 1018
<212> PRT
<213> Homo sapiens
<308> BAB13417
<400> 7351

Gln Leu Tyr Glu Met Phe Gln Gln Ile Leu Gly Ile Lys Lys Leu Glu 
  1               5                  10                  15
His Gln Leu Leu Tyr Asn Ala Cys Gln Leu Asp Asn Ala Asp Glu Gln 
             20                  25                  30
Ala Ala Gln Ile Arg Arg Glu Leu Asp Gly Arg Leu Gln Leu Ala Asp 
         35                  40                  45
Lys Met Ala Lys Glu Arg Lys Phe Pro Lys Phe Ile Ala Lys Asp Met 
     50                  55                  60
Glu Asn Met Tyr Ile Glu Glu Leu Arg Ser Ser Val Asn Leu Leu Met 
 65                  70                  75                  80
Ala Asn Leu Glu Ser Leu Pro Val Ser Lys Gly Gly Pro Glu Phe Lys 
                 85                  90                  95
Leu Gln Lys Leu Lys Arg Ser Gln Asn Ser Ala Phe Leu Asp Ile Gly 
             100                105                110
Asp Glu Asn Glu Ile Gln Leu Ser Lys Ser Asp Val Val Leu Ser Phe 
         115                120                125
Thr Leu Glu Ile Val Ile Met Glu Val Gln Gly Leu Lys Ser Val Ala 
     130                135                140
Pro Asn Arg Ile Val Tyr Cys Thr Met Glu Val Glu Gly Glu Lys Leu 
 145                150                155                160
Gln Thr Asp Gln Ala Glu Ala Ser Arg Pro Gln Trp Gly Thr Gln Gly 
                 165                170                175
Asp Phe Thr Thr Thr His Pro Arg Pro Val Val Lys Val Lys Leu Phe 
             180                185                190
Thr Glu Ser Thr Gly Val Leu Ala Leu Glu Asp Lys Glu Leu Gly Arg 
         195                200                205
Val Ile Leu Tyr Pro Thr Ser Asn Ser Ser Lys Ser Ala Glu Leu His 
     210                215                220
Arg Met Val Val Pro Lys Asn Ser Gln Asp Ser Asp Leu Lys Ile Lys 
 225                230                235                240
Leu Ala Val Arg Met Asp Lys Pro Ala His Met Lys His Ser Gly Tyr 
                 245                250                255
Leu Tyr Ala Leu Gly Gln Lys Val Trp Lys Arg Trp Lys Lys Arg Tyr 
             260                265                270
Phe Val Leu Val Gln Val Ser Gln Tyr Thr Phe Ala Met Cys Ser Tyr 
         275                280                285
Arg Glu Lys Lys Ser Glu Pro Gln Glu Leu Met Gln Leu Glu Gly Tyr 
     290                295                300
Thr Val Asp Tyr Thr Asp Pro His Pro Gly Leu Gln Gly Gly Cys Met 
 305                310                315                320
Phe Phe Asn Ala Val Lys Glu Gly Asp Thr Val Ile Phe Ala Ser Asp 
                 325                330                335
Asp Glu Gln Asp Arg Ile Leu Trp Val Gln Ala Met Tyr Arg Ala Thr 
             340                345                350
Gly Gln Ser Tyr Lys Pro Val Pro Ala Ile Gln Thr Gln Lys Leu Asn 
         355                360                365
Pro Lys Gly Gly Thr Leu His Ala Asp Ala Gln Leu Tyr Ala Asp Arg 
     370                375                380
Phe Gln Lys His Gly Met Asp Glu Phe Ile Ser Ala Asn Pro Cys Lys 
 385                390                395                400
Leu Asp His Ala Phe Leu Phe Arg Ile Leu Gln Arg Gln Thr Leu Asp 
                 405                410                415
His Arg Leu Asn Asp Ser Tyr Ser Cys Leu Gly Trp Phe Ser Pro Gly 
             420                425                430
Gln Val Phe Val Leu Asp Glu Tyr Cys Ala Arg Tyr Gly Val Arg Gly 
         435                440                445
Cys His Arg His Leu Cys Tyr Leu Ala Glu Leu Met Glu His Ser Glu 
     450                455                460
Asn Gly Ala Val Ile Asp Pro Thr Leu Leu His Tyr Ser Phe Ala Phe 
 465                470                475                480
Cys Ala Ser His Val His Gly Asn Arg Pro Asp Gly Ile Gly Thr Val 
                 485                490                495
Ser Val Glu Glu Lys Glu Arg Phe Glu Glu Ile Lys Glu Arg Leu Ser 
             500                505                510
Ser Leu Leu Glu Asn Gln Ile Ser His Phe Arg Tyr Cys Phe Pro Phe 
         515                520                525
Gly Arg Pro Glu Gly Ala Leu Lys Ala Thr Leu Ser Leu Leu Glu Arg 
     530                535                540
Val Leu Met Lys Asp Ile Ala Thr Pro Ile Pro Ala Glu Glu Val Lys 
 545                550                555                560
Lys Val Val Arg Lys Cys Leu Glu Lys Ala Ala Leu Ile Asn Tyr Thr 
                 565                570                575
Arg Leu Thr Glu Tyr Ala Lys Ile Glu Glu Thr Met Asn Gln Ala Ser 
             580                585                590
Pro Ala Arg Lys Leu Glu Glu Ile Leu His Leu Ala Glu Leu Cys Ile 
         595                600                605
Glu Val Leu Gln Gln Asn Glu Glu His His Ala Glu Ala Phe Ala Trp 
     610                615                620
Trp Pro Asp Leu Leu Ala Glu His Ala Glu Lys Phe Trp Ala Leu Phe 
 625                630                635                640
Thr Val Asp Met Asp Thr Ala Leu Glu Ala Gln Pro Gln Asp Ser Trp 
                 645                650                655
Asp Ser Phe Pro Leu Phe Gln Leu Leu Asn Asn Phe Leu Arg Asn Asp 
             660                665                670
Thr Leu Leu Cys Asn Gly Lys Phe His Lys His Leu Gln Glu Ile Phe 
         675                680                685
Val Pro Leu Val Val Arg Tyr Val Asp Leu Met Glu Ser Ser Ile Ala 
     690                695                700
Gln Ser Ile His Arg Gly Phe Glu Gln Glu Thr Trp Gln Pro Val Asn 
 705                710                715                720
Asn Gly Ser Ala Thr Ser Glu Asp Leu Phe Trp Lys Leu Asp Ala Leu 
                 725                730                735
Gln Met Phe Val Phe Asp Leu His Trp Pro Glu Gln Glu Phe Ala His 
             740                745                750
His Leu Glu Gln Arg Leu Lys Leu Met Ala Ser Asp Met Leu Glu Ala 
         755                760                765
Cys Val Lys Arg Thr Arg Thr Ala Phe Glu Leu Lys Leu Gln Lys Ala 
     770                775                780
Ser Lys Thr Thr Asp Leu Arg Ile Pro Ala Ser Val Cys Thr Met Phe 
 785                790                795                800
Asn Val Leu Val Asp Ala Lys Lys Gln Ser Thr Lys Leu Cys Ala Leu 
                 805                810                815
Asp Gly Gly Gln Glu Phe Gly Ser Gln Trp Gln Gln Tyr His Ser Lys 
             820                825                830
Ile Asp Asp Leu Ile Asp Asn Ser Val Lys Glu Ile Ile Ser Leu Leu 
         835                840                845
Val Ser Lys Phe Val Ser Val Leu Glu Gly Val Leu Ser Lys Leu Ser 
     850                855                860
Arg Tyr Asp Glu Gly Thr Phe Phe Ser Ser Ile Leu Ser Phe Thr Val 
 865                870                875                880
Lys Ala Ala Ala Lys Tyr Val Asp Val Pro Lys Pro Gly Met Asp Leu 
                 885                890                895
Ala Asp Thr Tyr Ile Met Phe Val Arg Gln Asn Gln Asp Ile Leu Arg 
             900                905                910
Glu Lys Val Asn Glu Glu Met Tyr Ile Glu Lys Leu Phe Asp Gln Trp 
         915                920                925
Tyr Ser Ser Ser Met Lys Val Ile Cys Val Trp Leu Thr Asp Arg Leu 
     930                935                940
Asp Leu Gln Leu His Ile Tyr Gln Leu Lys Thr Leu Ile Lys Ile Val 
 945                950                955                960
Lys Lys Thr Tyr Arg Asp Phe Arg Leu Gln Gly Val Leu Glu Gly Thr 
                 965                970                975
Leu Asn Ser Lys Thr Tyr Asp Thr Val His Arg Arg Leu Thr Val Glu 
             980                985                990
Glu Ala Thr Ala Ser Val Ser Glu Gly Gly Gly Leu Gln Gly Ile Thr 
         995                1000                1005
Met Lys Asp Ser Asp Glu Glu Glu Glu Gly 
     1010                1015



<210> 7352
<211> 345
<212> DNA
<213> Rattus norvegicus
<308> AI639118
<400> 7352

ttgtttgag  tactgcaaa  atcttttac  gcatttaat  tacttaatg  acatagaag  60
tgctctgac  gaatggatt  ttattgcca  caagctgtc  cacttgttg  cggaagcac  120
cctggcgat  tcgtacgca  ggaaaaaaa  tgttcagaa  caggatgta  gtctgtgaa  180
aatctagcc  acatttggg  gtgatactc  ctgaagtcc  ggattacac  tgcagacaa  240
ttcagagtt  tgaaaacca  gttttctcc  catcacaac  ctggcaaat  acagaacaa  300
ctttgtaca  aaatggtaa  tgggaggca  accactttg  cggaa  345



<210> 7353
<211> 2130
<212> DNA
<213> Homo sapiens
<308> AK000768
<400> 7353

agaaaatgt  tcgagaaag  tgccttgat  aattacact  gactcaccg  atatgccaa  60
atagaagag  ccatgaacc  ggcatctcc  gctagaaag  tggaagaga  tcttcatct  120
gcagagctc  gcatagaag  cttacagca  aatgaagag  atcatgcag  ggcatttgc  180
tggtggcct  atttattgg  tgaacatgc  gagaaattt  gggctttat  tacagtgga  240
atggacact  cactagagg  tcaaccgca  gactcctgg  atagttttc  tcttttcca  300
ctgcttaat  atttcctcc  aaatgacac  cttttgtgt  atggaaaat  tcacaaaca  360
ttgcaagaa  tctttgtac  cttggttgt  cgctatgtg  atctcatgg  gtcttccat  420
gcccagtca  ttcacagag  ttttgagca  gagacatgg  agcctgtca  caatggctc  480
gcaacatca  aagaccttt  ttggaagct  gatgcactg  aaatgtttg  ctttgatct  540
cactggcca  aacaggaat  tgcccacca  ttagagcaa  gacttaaac  aatggccag  600
gatatgcta  aggcctgtg  caaaagaac  agaactgca  ttgaactca  gctacaaaa  660
gcaagcaaa  caactgact  gcgcattcc  gcttccgtt  gcactatgt  taatgtatt  720
gtcgatgcc  aaaagcaaa  caccaaact  tgtgccctg  atggaggac  agagtttgg  780
agtcaatgg  aacagtacc  ttcaaaaat  gatgatctg  tcgacaaca  tgtaaaaga  840
atcatttca  tgttagttt  aaagtttgt  tcagtgttg  aaggcgtgt  gtctaagct  900
tcaaggtat  atgaaggca  tttcttttc  tccattctg  cattcactg  gaaagcagc  960
gcaaaatat  ttgatgttc  aaaaccagg  atggatctg  cagacacct  tattatgtt  1020
gttcggcaa  accaagata  tcttcgaga  aaggtcaat  aggaaatgt  tatagaaaa  1080
ttatttgat  aatggtaca  cagttccat  aaagtcatt  gcgtgtggt  gactgatag  1140
ttagacctc  aactccata  ttaccagct  aagacgctc  tcaagattg  gaagaaaac  1200
tacagggac  ttcgattgc  gggtgtgtt  gaaggaaca  tgaacagta  gacttatga  1260
actgtgcac  gacgtttaa  agtagagga  gccacagcc  ctgtttcag  aggaggagg  1320
cttcagggc  ttactatga  agacagtga  gaagaagaa  aaggctgat  tcacacagc  1380
ttgcagaag  aaggaagac  ttgatcgac  ttgtttttt  tttttttaa  cttgtcctt  1440
taattacat  cattgtttg  tttggccaa  taaaaatgc  tgtatttct  taaaaagta  1500
gcctgaatg  agagtaaaa  gggaaatgc  aagattttg  ggttttttt  tttcctttt  1560
ttgtttgtt  gtttgtttt  ttggagaag  gcatcctct  ttgtgtagt  tgacctaaa  1620
atgaacctt  gctctgctt  tgatcagaa  atgaacttt  ttttttaaa  aagatttga  1680
catttttct  taatcacat  aaaatgatg  tttctgtgt  aagcgagat  catatttct  1740
ataatgcag  attgtgaga  gtcagctcg  accactgca  caacactgt  gtatccttg  1800
taaaatggt  tgtacctta  aaattataa  ttatgtgcc  ggttcgttt  gtacttaat  1860
tgctattat  gtgatgtgt  taaaatctt  aatcttggt  cttagtact  tgaattggt  1920
tacaggtat  ttcctggga  gaaaggatt  ccaaaccca  atatagact  gattatcca  1980
tgggtttgt  tctttgttc  attctcaac  tttcttctt  caactataa  taatcccca  2040
gtgtggggt  gcaagtgtg  ttccgtcaa  ataccatat  ctcctgctc  agtataaca  2100
cttgcaggc  ataaaaatc  atttgctcat  2130



<210> 7354
<211> 1018
<212> PRT
<213> Homo sapiens
<308> BAB13417
<400> 7354

Gln Leu Tyr Glu Met Phe Gln Gln Ile Leu Gly Ile Lys Lys Leu Glu 
  1               5                  10                  15
His Gln Leu Leu Tyr Asn Ala Cys Gln Leu Asp Asn Ala Asp Glu Gln 
             20                  25                  30
Ala Ala Gln Ile Arg Arg Glu Leu Asp Gly Arg Leu Gln Leu Ala Asp 
         35                  40                  45
Lys Met Ala Lys Glu Arg Lys Phe Pro Lys Phe Ile Ala Lys Asp Met 
     50                  55                  60
Glu Asn Met Tyr Ile Glu Glu Leu Arg Ser Ser Val Asn Leu Leu Met 
 65                  70                  75                  80
Ala Asn Leu Glu Ser Leu Pro Val Ser Lys Gly Gly Pro Glu Phe Lys 
                 85                  90                  95
Leu Gln Lys Leu Lys Arg Ser Gln Asn Ser Ala Phe Leu Asp Ile Gly 
             100                105                110
Asp Glu Asn Glu Ile Gln Leu Ser Lys Ser Asp Val Val Leu Ser Phe 
         115                120                125
Thr Leu Glu Ile Val Ile Met Glu Val Gln Gly Leu Lys Ser Val Ala 
     130                135                140
Pro Asn Arg Ile Val Tyr Cys Thr Met Glu Val Glu Gly Glu Lys Leu 
 145                150                155                160
Gln Thr Asp Gln Ala Glu Ala Ser Arg Pro Gln Trp Gly Thr Gln Gly 
                 165                170                175
Asp Phe Thr Thr Thr His Pro Arg Pro Val Val Lys Val Lys Leu Phe 
             180                185                190
Thr Glu Ser Thr Gly Val Leu Ala Leu Glu Asp Lys Glu Leu Gly Arg 
         195                200                205
Val Ile Leu Tyr Pro Thr Ser Asn Ser Ser Lys Ser Ala Glu Leu His 
     210                215                220
Arg Met Val Val Pro Lys Asn Ser Gln Asp Ser Asp Leu Lys Ile Lys 
 225                230                235                240
Leu Ala Val Arg Met Asp Lys Pro Ala His Met Lys His Ser Gly Tyr 
                 245                250                255
Leu Tyr Ala Leu Gly Gln Lys Val Trp Lys Arg Trp Lys Lys Arg Tyr 
             260                265                270
Phe Val Leu Val Gln Val Ser Gln Tyr Thr Phe Ala Met Cys Ser Tyr 
         275                280                285
Arg Glu Lys Lys Ser Glu Pro Gln Glu Leu Met Gln Leu Glu Gly Tyr 
     290                295                300
Thr Val Asp Tyr Thr Asp Pro His Pro Gly Leu Gln Gly Gly Cys Met 
 305                310                315                320
Phe Phe Asn Ala Val Lys Glu Gly Asp Thr Val Ile Phe Ala Ser Asp 
                 325                330                335
Asp Glu Gln Asp Arg Ile Leu Trp Val Gln Ala Met Tyr Arg Ala Thr 
             340                345                350
Gly Gln Ser Tyr Lys Pro Val Pro Ala Ile Gln Thr Gln Lys Leu Asn 
         355                360                365
Pro Lys Gly Gly Thr Leu His Ala Asp Ala Gln Leu Tyr Ala Asp Arg 
     370                375                380
Phe Gln Lys His Gly Met Asp Glu Phe Ile Ser Ala Asn Pro Cys Lys 
 385                390                395                400
Leu Asp His Ala Phe Leu Phe Arg Ile Leu Gln Arg Gln Thr Leu Asp 
                 405                410                415
His Arg Leu Asn Asp Ser Tyr Ser Cys Leu Gly Trp Phe Ser Pro Gly 
             420                425                430
Gln Val Phe Val Leu Asp Glu Tyr Cys Ala Arg Tyr Gly Val Arg Gly 
         435                440                445
Cys His Arg His Leu Cys Tyr Leu Ala Glu Leu Met Glu His Ser Glu 
     450                455                460
Asn Gly Ala Val Ile Asp Pro Thr Leu Leu His Tyr Ser Phe Ala Phe 
 465                470                475                480
Cys Ala Ser His Val His Gly Asn Arg Pro Asp Gly Ile Gly Thr Val 
                 485                490                495
Ser Val Glu Glu Lys Glu Arg Phe Glu Glu Ile Lys Glu Arg Leu Ser 
             500                505                510
Ser Leu Leu Glu Asn Gln Ile Ser His Phe Arg Tyr Cys Phe Pro Phe 
         515                520                525
Gly Arg Pro Glu Gly Ala Leu Lys Ala Thr Leu Ser Leu Leu Glu Arg 
     530                535                540
Val Leu Met Lys Asp Ile Ala Thr Pro Ile Pro Ala Glu Glu Val Lys 
 545                550                555                560
Lys Val Val Arg Lys Cys Leu Glu Lys Ala Ala Leu Ile Asn Tyr Thr 
                 565                570                575
Arg Leu Thr Glu Tyr Ala Lys Ile Glu Glu Thr Met Asn Gln Ala Ser 
             580                585                590
Pro Ala Arg Lys Leu Glu Glu Ile Leu His Leu Ala Glu Leu Cys Ile 
         595                600                605
Glu Val Leu Gln Gln Asn Glu Glu His His Ala Glu Ala Phe Ala Trp 
     610                615                620
Trp Pro Asp Leu Leu Ala Glu His Ala Glu Lys Phe Trp Ala Leu Phe 
 625                630                635                640
Thr Val Asp Met Asp Thr Ala Leu Glu Ala Gln Pro Gln Asp Ser Trp 
                 645                650                655
Asp Ser Phe Pro Leu Phe Gln Leu Leu Asn Asn Phe Leu Arg Asn Asp 
             660                665                670
Thr Leu Leu Cys Asn Gly Lys Phe His Lys His Leu Gln Glu Ile Phe 
         675                680                685
Val Pro Leu Val Val Arg Tyr Val Asp Leu Met Glu Ser Ser Ile Ala 
     690                695                700
Gln Ser Ile His Arg Gly Phe Glu Gln Glu Thr Trp Gln Pro Val Asn 
 705                710                715                720
Asn Gly Ser Ala Thr Ser Glu Asp Leu Phe Trp Lys Leu Asp Ala Leu 
                 725                730                735
Gln Met Phe Val Phe Asp Leu His Trp Pro Glu Gln Glu Phe Ala His 
             740                745                750
His Leu Glu Gln Arg Leu Lys Leu Met Ala Ser Asp Met Leu Glu Ala 
         755                760                765
Cys Val Lys Arg Thr Arg Thr Ala Phe Glu Leu Lys Leu Gln Lys Ala 
     770                775                780
Ser Lys Thr Thr Asp Leu Arg Ile Pro Ala Ser Val Cys Thr Met Phe 
 785                790                795                800
Asn Val Leu Val Asp Ala Lys Lys Gln Ser Thr Lys Leu Cys Ala Leu 
                 805                810                815
Asp Gly Gly Gln Glu Phe Gly Ser Gln Trp Gln Gln Tyr His Ser Lys 
             820                825                830
Ile Asp Asp Leu Ile Asp Asn Ser Val Lys Glu Ile Ile Ser Leu Leu 
         835                840                845
Val Ser Lys Phe Val Ser Val Leu Glu Gly Val Leu Ser Lys Leu Ser 
     850                855                860
Arg Tyr Asp Glu Gly Thr Phe Phe Ser Ser Ile Leu Ser Phe Thr Val 
 865                870                875                880
Lys Ala Ala Ala Lys Tyr Val Asp Val Pro Lys Pro Gly Met Asp Leu 
                 885                890                895
Ala Asp Thr Tyr Ile Met Phe Val Arg Gln Asn Gln Asp Ile Leu Arg 
             900                905                910
Glu Lys Val Asn Glu Glu Met Tyr Ile Glu Lys Leu Phe Asp Gln Trp 
         915                920                925
Tyr Ser Ser Ser Met Lys Val Ile Cys Val Trp Leu Thr Asp Arg Leu 
     930                935                940
Asp Leu Gln Leu His Ile Tyr Gln Leu Lys Thr Leu Ile Lys Ile Val 
 945                950                955                960
Lys Lys Thr Tyr Arg Asp Phe Arg Leu Gln Gly Val Leu Glu Gly Thr 
                 965                970                975
Leu Asn Ser Lys Thr Tyr Asp Thr Val His Arg Arg Leu Thr Val Glu 
             980                985                990
Glu Ala Thr Ala Ser Val Ser Glu Gly Gly Gly Leu Gln Gly Ile Thr 
         995                1000                1005
Met Lys Asp Ser Asp Glu Glu Glu Glu Gly 
     1010                1015



<210> 7355
<211> 457
<212> DNA
<213> Rattus norvegicus
<308> AI639120
<400> 7355

ttgccaagt  aaatgtgtt  attggccag  taatcattg  ggttaaaca  ttgcctaag  60
ctacaaggc  gcaaagact  agatcctaa  gaaggaaag  atcatgttc  cttttaggt  120
cagaaaggc  gaacagagc  cctgaggcc  gctgtgaca  cagaaaagc  ggagagagg  180
tgccctcag  cacacgtcc  aggtggtga  cctgagctt  accatggtg  gcctgggcc  240
ttccctaga  aggcttcag  acagtagct  ggacatgga  atcccactg  ggctctgca  300
ccctgggca  cgtctaggg  actgtctca  gccccagga  agtgccata  catgatctg  360
catggcctg  gtgggtgga  aggcctggg  ggtgacact  cagagtgaa  ggctccagt  420
ctggctgtt  tgctaggtt  gcagtctca  tgggcga  457



<210> 7356
<211> 351
<212> DNA
<213> Rattus norvegicus
<308> AI639123
<400> 7356

ttaaagctt  ctggtttat  tgaagaggc  aattagcat  agtaaatca  gagttaaga  60
gacaagcta  acctttgtt  ctactcatt  gatgaaacc  caggagttt  cagttaagc  120
tctgtggga  ccggggatg  gagtaggaa  cagagacca  agctccagt  tctgtaaac  180
gaatcagag  caatgatga  actgggttt  agccaaggc  acttttcat  ccaaccgga  240
gccacataa  tctactgta  tctcgttaa  aagtcaaga  ccgtatctc  cggcggcaa  300
aacaagcaa  gccacagcc  ctctctact  ctttaaaat  gacacagct  g  351



<210> 7357
<211> 612
<212> PRT
<213> Rattus norvegicus
<308> AAC40148
<400> 7357

Met Val His Gly Gly Phe Pro Glu Lys Ile Arg Gln Arg Tyr Ala Asp 
  1               5                  10                  15
Leu Pro Gly Glu Leu His Ile Ile Glu Leu Glu Lys Asp Lys Asn Gly 
             20                  25                  30
Leu Gly Leu Ser Leu Ala Gly Asn Lys Asp Arg Ser Arg Met Ser Ile 
         35                  40                  45
Phe Val Val Gly Ile Asn Pro Glu Gly Pro Ala Ala Ala Asp Gly Arg 
     50                  55                  60
Met Arg Ile Gly Asp Glu Leu Leu Glu Ile Asn Asn Gln Ile Leu Tyr 
 65                  70                  75                  80
Gly Arg Ser His Gln Asn Ala Ser Ala Ile Ile Lys Thr Ala Pro Thr 
                 85                  90                  95
Arg Val Lys Leu Val Phe Ile Arg Asn Glu Asp Ala Val Ser Gln Met 
             100                105                110
Ala Val Ala Pro Phe Pro Glu Leu Ser His Ser Pro Ser Pro Val Glu 
         115                120                125
Asp Leu Gly Gly Thr Glu Leu Val Ser Ser Glu Glu Glu Ser Ser Val 
     130                135                140
Asp Ala Lys His Leu Pro Glu Pro Glu Ser Ser Lys Pro Glu Asp Leu 
 145                150                155                160
Ser Gln Val Val Asp Asp Asn Met Val Ala Glu Gln Gln Lys Glu Ser 
                 165                170                175
Glu Ser Pro Asp Ser Ala Ala Cys Gln Ile Lys Gln Gln Thr Tyr Ser 
             180                185                190
Thr Gln Val Ser Ser Ser Ser Gln Asp Ser Pro Ser Ser Pro Ala Pro 
         195                200                205
Leu Cys Gln Ser Ala His Ala Asp Val Thr Gly Ser Gly Asn Phe Gln 
     210                215                220
Ala Pro Leu Pro Val Asp Pro Ala Pro Leu Ser Val Asp Pro Ala Thr 
 225                230                235                240
Cys Pro Ile Val Pro Gly Gln Glu Met Ile Ile Glu Ile Ser Lys Gly 
                 245                250                255
Arg Ser Gly Leu Gly Leu Ser Ile Val Gly Gly Lys Asp Thr Pro Leu 
             260                265                270
Asp Ala Ile Val Ile His Glu Val Tyr Glu Glu Gly Ala Ala Ala Arg 
         275                280                285
Asp Gly Arg Leu Trp Ala Gly Asp Gln Ile Leu Glu Val Asn Gly Val 
     290                295                300
Asp Leu Arg Ser Ser Ser His Glu Glu Ala Ile Thr Ala Leu Arg Gln 
 305                310                315                320
Thr Pro Gln Lys Val Arg Leu Val Val Tyr Arg Asp Glu Ala Gln Tyr 
                 325                330                335
Arg Asp Glu Glu Asn Leu Glu Val Phe Leu Val Asp Leu Gln Lys Lys 
             340                345                350
Thr Gly Arg Gly Leu Gly Leu Ser Ile Val Gly Lys Arg Ser Gly Ser 
         355                360                365
Gly Val Phe Ile Ser Asp Ile Val Lys Gly Gly Ala Ala Asp Leu Asp 
     370                375                380
Gly Arg Leu Ile Arg Gly Asp Gln Ile Leu Ser Val Asn Gly Glu Asp 
 385                390                395                400
Met Arg His Ala Ser Gln Glu Thr Val Ala Thr Ile Leu Lys Cys Val 
                 405                410                415
Gln Gly Leu Val Gln Leu Glu Ile Gly Arg Leu Arg Ala Gly Ser Trp 
             420                425                430
Ala Ala Ser Arg Lys Thr Ser Gln Asn Ser Gln Gly Asp Gln His Ser 
         435                440                445
Ala His Ser Ser Cys Arg Pro Ser Phe Ala Pro Val Ile Thr Ser Leu 
     450                455                460
Gln Asn Leu Val Gly Thr Lys Arg Ser Ser Asp Pro Pro Gln Lys Cys 
 465                470                475                480
Thr Glu Glu Glu Pro Arg Thr Val Glu Ile Ile Arg Glu Leu Ser Asp 
                 485                490                495
Ala Leu Gly Ile Ser Ile Ala Gly Gly Lys Gly Ser Pro Leu Gly Asp 
             500                505                510
Ile Pro Ile Phe Ile Ala Met Ile Gln Ala Asn Gly Val Ala Ala Arg 
         515                520                525
Thr Gln Lys Leu Lys Val Gly Asp Arg Ile Val Ser Ile Asn Gly Gln 
     530                535                540
Pro Leu Asp Gly Leu Ser His Thr Asp Ala Val Asn Leu Leu Lys Asn 
 545                550                555                560
Ala Phe Gly Arg Ile Ile Leu Gln Val Val Ala Asp Thr Asn Ile Ser 
                 565                570                575
Ala Ile Ala Thr Gln Leu Glu Ile Met Ser Ala Gly Ser Gln Leu Gly 
             580                585                590
Ser Pro Thr Ala Asp Arg His Pro Glu Asp Thr Glu Glu Gln Met Gln 
         595                600                605
Arg Thr Ala Asp 
     610



<210> 7358
<211> 5033
<212> DNA
<213> Homo sapiens
<308> AB044807
<400> 7358

acgagatta  gaagtaatg  ttgctactt  ggacacaca  attgcagat  atgctgagt  60
acagaaata  tcaaagctg  tgcctattc  cactctgag  cttggtgtg  aagtggatt  120
ctttgatgg  caccattat  tttcttcaa  tgtttctgg  ggtcctgtt  atacattgg  180
tctcctaca  ccagaagat  agctgcttg  ggtcaatgg  atgcagctt  atggaaaat  240
tcgccgaga  gcagtctcc  ttcttaaag  agtgccacc  ccttttact  tggtttgct  300
tcggaggtt  tttgatgat  aagcttctg  agatgaacc  aggcgcact  aaacctctc  360
tcctgagac  gaggttgac  acaatatgg  tgtcaatac  gaagaagat  atgatgggg  420
attagcact  tggtcccct  aagtcaaga  tgttgaact  gtaaaagat  gtaaaggtt  480
gggattcag  attttggat  accaggacc  tttagatcc  acaagatca  tgattgtga  540
ccgctccct  gtagcagat  gtgtagcag  aagaagtgg  ggactatta  ctggagacc  600
cctggtctc  gtcaatgaa  actgtttgg  caacacctc  cttgctgaa  ctgtggaaa  660
attgaaagc  gtgccacca  gcctagtac  ccttggcat  tgtaagcct  tggtggaag  720
taatgaaga  gaaagttgt  atattttac  ttcaagcag  aatgaagac  agactgaat  780
ttcaggaac  attcatgat  taaattcat  tttaatact  gaagcaccc  agggattta  840
agatgaacc  tattttaaa  aagaacttg  ggatgaacc  tttctagat  tgggaaagt  900
tttccattc  caacaaaaa  agatagagc  aagcaagga  gcctgggag  tgcatgaat  960
tctgactcc  agattgcag  aaatggatg  agaaagaga  atgcttgtt  atgaagaat  1020
tgagttata  caagatccc  caccatcca  ggagttgta  cccttgtcg  acattcaag  1080
ggccactcc  gtgccctct  tgaatgaac  tcactttgg  acacagtgg  tgcatgata  1140
tgaaccatc  gagtctcaa  aggcaagaa  cgggaggac  gtctattcc  aggaggcac  1200
gccgtatgg  tattgccct  aaaatgtga  gaaagaaaa  tttgtcatg  agtccctac  1260
atctgtacc  tcaactgaa  gaaacagtc  acaaggcag  tttgacgac  tggaaaatc  1320
taattcatt  gcaaaaact  gtctggatt  aggcatgat  ccgaatgat  tccaaggtc  1380
tagcttgct  attgacctt  ctgttgtgg  tcaaaggag  gagcaagaa  atttgcctt  1440
atatcaaca  caagcgaca  gagttattt  caaggcctc  gcatacaca  gaatgttgt  1500
ttctagata  gccactgat  catgtgagt  acctgagag  gaagaaggc  aaggagaag  1560
aactccaaa  tttagccac  ggggtccac  gagaattgt  gagattttt  gagaaccca  1620
tgtgtctct  gggatcagt  ttgttggtg  acaaactgt  ataaaacgt  taaagaatg  1680
agaggagct  aaaggtata  tcatcaaac  agttttaga  gacagtcca  cagggaaga  1740
gaacgcact  aaaactgga  ataaaatac  tgaggtgtc  ggagtagat  tgcagaatg  1800
ctcacacag  gaagcagtt  aggccatta  gaatgcagg  aaccctgtg  tgttcattg  1860
tcagagttt  tcatccact  cacgagtca  tcctaacgt  cataacaag  ccaacaaaa  1920
caccggtaa  cagaaccag  acacccaag  aaagaaaga  aagaggcaa  gaactgctc  1980
accgccaat  aaacttcct  ctccttata  agctctgac  gatgacagt  atgaaaatg  2040
agaagaaga  gcctttacc  accaaaaaa  cagacaaag  tatgcagat  tgcctggag  2100
actgcacat  attgaactt  aaaaagata  gaatggact  ggactcagc  ttgctggta  2160
taaagaccg  tcacgcatg  gcatatttg  ggtgggaat  aacccggaa  gacctgctg  2220
cgcagatgg  cgaatgcat  ttggagatg  actcttaga  ataaacaat  agattctgt  2280
tggaagaag  caccaaaat  catctgcca  tattaagac  gccccatca  aggtcaagc  2340
ggttttcat  agaaacgag  atgcagtca  tcagatggc  gttactccc  ttccagtgc  2400
atcaagttc  ccatcttct  ttgaggatc  gagcggcac  gaacctatt  gtagtgagg  2460
agatggcag  ctcgaagtt  gtattaaac  attgcctga  agtgaaagc  tcaaactgg  2520
tgtcagcca  atgaaacag  aaaaatatc  aacaaaagt  tccttcagt  cacaagaga  2580
accattagc  ccagcttca  cataccatt  aacagatgc  gacttcaca  gctatggtg  2640
tttccaggc  cctctgtca  tggaccccg  aacgtgtcc  attgtccct  gacaggaaa  2700
gattataga  atatccaag  gacgttcag  gcttggtct  agcattgtg  gaggaaaag  2760
cacaccctt  aatgctata  ttatccatg  agtctatga  gaaggggca  cagccagag  2820
tggaagact  tgggctggt  accagatat  agaggttaa  ggggttgac  tgaggaact  2880
cagccacga  gaagccatc  cagccctga  gcagacccc  cagaaggtg  ggctggtgg  2940
gtatagaga  gaagcacac  accgggatg  ggagaactt  gagattttc  ctgtggatc  3000
gcagaagaa  gctggccgg  gcctgggcc  gagcatcgt  gggaaacga  atggaagcg  3060
agtgtttat  tctgacatc  tgaaaggcg  agccgcaga  ctggatggg  gattgattc  3120
gggagatca  atcttatct  tgaatgggg  ggacatgag  aatgcctca  aggagacag  3180
ggccaccat  ctcaagtgt  cacagggac  tgtgcagct  gagattgga  gactccgag  3240
tggttcctg  acctccgca  ggacgacat  acagaacag  cagtcagca  agtgcacac  3300
gcagctgtc  tccctcctt  gctcctgtc  tcactggcc  gcaaaacct  gttggcaca  3360
aaagagttt  agatccttc  cagaaaaat  caggcacag  tatggaacc  aggactgtt  3420
agataaaca  ggagctcag  gatgccctt  gaatcagta  tgctggagg  agaggaagt  3480
ccttaggag  tatccccgt  tttattgcc  tgattcagg  tagcggagt  gccgcacgg  3540
cacagaagc  taaagttgg  gatcggatt  tcagcatta  cgggcaacc  ttggatggg  3600
tgtctcacg  ggatgtggt  aatctgctg  agaatgcct  cgggcgcat  atcctgcag  3660
ttgtagcag  taccaatat  agcgccata  cagctcagc  tgaaaacat  tctacaggc  3720
accaccttg  ttcgcccac  gctgaacac  atccagaag  cacagaaac  cctccacct  3780
agattatta  tttggagaa  ggctctgaa  gcttggggt  tagtattgt  gggggttat  3840
gaagtcccc  tggagacct  ccaatttat  tcaagactg  atttgcaaa  ggagcagct  3900
cagatgacg  ccgattaaa  cgaggggat  agattttag  tgttaatgg  gagaccctg  3960
aaggtgtta  tcatgagca  gcagtcgcc  ttctaaaac  ccagagagg  actgtaacc  4020
taactgtgc  gtcatgagc  tcgggcctg  tcacaagat  gatgttgtt  tttagaata  4080
ccacaggca  atgaagttc  gagtgggta  gaaaagcac  ctcaactaa  atgcacctt  4140
attcttatt  cttgccctc  ctgctcagg  gaaatggct  aggtttcat  tgaatttcc  4200
aaatcaaca  tcatctcct  atgtttccc  gttcctgtc  cctgttggc  aggttgatt  4260
ctaaaactt  aatgagtct  cctgttttg  atttaattt  agtgttccg  tttcttttt  4320
ttttttttt  ttttttgag  cggagtctc  ctctgtcac  caggctggg  tgcagtgag  4380
caagttcgt  ccactccac  ccagcctgg  tgacagagc  agactctgt  tcgaaaaag  4440
aaaaaaacc  tgaaggatg  gtactagag  cagtaatag  agtagttca  cattattta  4500
ctacaacac  atgctgcaa  tatttcaca  taattatca  aatttaatg  gctctaatt  4560
aaaatgtta  ttaataagt  tagatttta  ttgagaatt  tctttgagt  gatgtaatc  4620
caaagtgca  taactcttg  tggaatatt  tatggctat  ccaaagtat  gagtgccta  4680
attttgtgt  gaaaatgtc  ttcatgacg  tattaagtt  tctgaaatt  cacatggct  4740
ttaaaattt  taatgtatc  aagatgtgc  atgttgtta  gatctcatt  ttcagtgca  4800
gaaaarcta  taccctcag  acattttgt  ttaattgta  ctgcaagaa  acctcaggc  4860
agccaagaa  aaatgaaac  caaataaaa  ttgaaaatg  accttaaaa  tatatatac  4920
tataatagt  ttgaaatgg  attctgctt  attttgatg  aatggccat  aaatacaca  4980
tttgagata  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaa  5033



<210> 7359
<211> 1134
<212> PRT
<213> Homo sapiens
<308> BAB19683
<400> 7359

Met Val Ala Thr Leu Asp Thr Gln Ile Ala Asp Asp Ala Glu Leu Gln 
  1               5                  10                  15
Lys Tyr Ser Lys Leu Leu Pro Ile His Thr Leu Arg Leu Gly Val Glu 
             20                  25                  30
Val Asp Ser Phe Asp Gly His His Tyr Ile Ser Ser Ile Val Ser Gly 
         35                  40                  45
Gly Pro Val Asp Thr Leu Gly Leu Leu Gln Pro Glu Asp Glu Leu Leu 
     50                  55                  60
Glu Val Asn Gly Met Gln Leu Tyr Gly Lys Ser Arg Arg Glu Ala Val 
 65                  70                  75                  80
Ser Phe Leu Lys Glu Val Pro Pro Pro Phe Thr Leu Val Cys Cys Arg 
                 85                  90                  95
Arg Leu Phe Asp Asp Glu Ala Ser Val Asp Glu Pro Arg Arg Thr Glu 
             100                105                110
Thr Ser Leu Pro Glu Thr Glu Val Asp His Asn Met Asp Val Asn Thr 
         115                120                125
Glu Glu Asp Asp Asp Gly Glu Leu Ala Leu Trp Ser Pro Glu Val Lys 
     130                135                140
Ile Val Glu Leu Val Lys Asp Cys Lys Gly Leu Gly Phe Ser Ile Leu 
 145                150                155                160
Asp Tyr Gln Asp Pro Leu Asp Pro Thr Arg Ser Val Ile Val Ile Arg 
                 165                170                175
Ser Leu Val Ala Asp Gly Val Ala Glu Arg Ser Gly Gly Leu Leu Pro 
             180                185                190
Gly Asp Arg Leu Val Ser Val Asn Glu Tyr Cys Leu Asp Asn Thr Ser 
         195                200                205
Leu Ala Glu Ala Val Glu Ile Leu Lys Ala Val Pro Pro Gly Leu Val 
     210                215                220
His Leu Gly Ile Cys Lys Pro Leu Val Glu Asp Asn Glu Glu Glu Ser 
 225                230                235                240
Cys Tyr Ile Leu His Ser Ser Ser Asn Glu Asp Lys Thr Glu Phe Ser 
                 245                250                255
Gly Thr Ile His Asp Ile Asn Ser Ser Leu Ile Leu Glu Ala Pro Lys 
             260                265                270
Gly Phe Arg Asp Glu Pro Tyr Phe Lys Glu Glu Leu Val Asp Glu Pro 
         275                280                285
Phe Leu Asp Leu Gly Lys Ser Phe His Ser Gln Gln Lys Glu Ile Glu 
     290                295                300
Gln Ser Lys Glu Ala Trp Glu Met His Glu Phe Leu Thr Pro Arg Leu 
 305                310                315                320
Gln Glu Met Asp Glu Glu Arg Glu Met Leu Val Asp Glu Glu Tyr Glu 
                 325                330                335
Leu Tyr Gln Asp Pro Ser Pro Ser Met Glu Leu Tyr Pro Leu Ser His 
             340                345                350
Ile Gln Glu Ala Thr Pro Val Pro Ser Val Asn Glu Leu His Phe Gly 
         355                360                365
Thr Gln Trp Leu His Asp Asn Glu Pro Ser Glu Ser Gln Glu Ala Arg 
     370                375                380
Thr Gly Arg Thr Val Tyr Ser Gln Glu Ala Gln Pro Tyr Gly Tyr Cys 
 385                390                395                400
Pro Glu Asn Val Met Lys Glu Asn Phe Val Met Glu Ser Leu Pro Ser 
                 405                410                415
Val Pro Ser Thr Glu Gly Asn Ser Gln Gln Gly Arg Phe Asp Asp Leu 
             420                425                430
Glu Asn Leu Asn Ser Leu Ala Lys Thr Ser Leu Asp Leu Gly Met Ile 
         435                440                445
Pro Asn Asp Val Gln Gly Pro Ser Leu Leu Ile Asp Leu Pro Val Val 
     450                455                460
Ala Gln Arg Arg Glu Gln Glu Asp Leu Pro Leu Tyr Gln His Gln Ala 
 465                470                475                480
Thr Arg Val Ile Ser Lys Ala Ser Ala Tyr Thr Gly Met Leu Ser Ser 
                 485                490                495
Arg Tyr Ala Thr Asp Thr Cys Glu Leu Pro Glu Arg Glu Glu Gly Glu 
             500                505                510
Gly Glu Glu Thr Pro Asn Phe Ser His Trp Gly Pro Pro Arg Ile Val 
         515                520                525
Glu Ile Phe Arg Glu Pro Asn Val Ser Leu Gly Ile Ser Ile Val Gly 
     530                535                540
Gly Gln Thr Val Ile Lys Arg Leu Lys Asn Gly Glu Glu Leu Lys Gly 
 545                550                555                560
Ile Phe Ile Lys Gln Val Leu Glu Asp Ser Pro Ala Gly Lys Thr Asn 
                 565                570                575
Ala Leu Lys Thr Gly Asp Lys Ile Leu Glu Val Ser Gly Val Asp Leu 
             580                585                590
Gln Asn Ala Ser His Ser Glu Ala Val Glu Ala Ile Lys Asn Ala Gly 
         595                600                605
Asn Pro Val Val Phe Ile Val Gln Ser Leu Ser Ser Thr Pro Arg Val 
     610                615                620
Ile Pro Asn Val His Asn Lys Ala Asn Lys Ile Thr Gly Asn Gln Asn 
 625                630                635                640
Gln Asp Thr Gln Glu Lys Lys Glu Lys Arg Gln Gly Thr Ala Pro Pro 
                 645                650                655
Pro Met Lys Leu Pro Pro Pro Tyr Lys Ala Leu Thr Asp Asp Ser Asp 
             660                665                670
Glu Asn Glu Glu Glu Asp Ala Phe Thr Asp Gln Lys Ile Arg Gln Arg 
         675                680                685
Tyr Ala Asp Leu Pro Gly Glu Leu His Ile Ile Glu Leu Glu Lys Asp 
     690                695                700
Lys Asn Gly Leu Gly Leu Ser Leu Ala Gly Asn Lys Asp Arg Ser Arg 
 705                710                715                720
Met Ser Ile Phe Val Val Gly Ile Asn Pro Glu Gly Pro Ala Ala Ala 
                 725                730                735
Asp Gly Arg Met His Ile Gly Asp Glu Leu Leu Glu Ile Asn Asn Gln 
             740                745                750
Ile Leu Tyr Gly Arg Ser His Gln Asn Ala Ser Ala Ile Ile Lys Thr 
         755                760                765
Ala Pro Ser Lys Val Lys Leu Val Phe Ile Arg Asn Glu Asp Ala Val 
     770                775                780
Asn Gln Met Ala Val Thr Pro Phe Pro Val Pro Ser Ser Ser Pro Ser 
 785                790                795                800
Ser Ile Glu Asp Gln Ser Gly Thr Glu Pro Ile Ser Ser Glu Glu Asp 
                 805                810                815
Gly Ser Leu Glu Val Gly Ile Lys Gln Leu Pro Glu Ser Glu Ser Phe 
             820                825                830
Lys Leu Ala Val Ser Gln Met Lys Gln Gln Lys Tyr Pro Thr Lys Val 
         835                840                845
Ser Phe Ser Ser Gln Glu Ile Pro Leu Ala Pro Ala Ser Ser Tyr His 
     850                855                860
Ser Thr Asp Ala Asp Phe Thr Gly Tyr Gly Gly Phe Gln Ala Pro Leu 
 865                870                875                880
Ser Val Asp Pro Ala Thr Cys Pro Ile Val Pro Gly Gln Glu Met Ile 
                 885                890                895
Ile Glu Ile Ser Lys Gly Arg Ser Gly Leu Gly Leu Ser Ile Val Gly 
             900                905                910
Gly Lys Asp Thr Pro Leu Asn Ala Ile Val Ile His Glu Val Tyr Glu 
         915                920                925
Glu Gly Ala Ala Ala Arg Asp Gly Arg Leu Trp Ala Gly Asp Gln Ile 
     930                935                940
Leu Glu Val Asn Gly Val Asp Leu Arg Asn Ser Ser His Glu Glu Ala 
 945                950                955                960
Ile Thr Ala Leu Arg Gln Thr Pro Gln Lys Val Arg Leu Val Val Tyr 
                 965                970                975
Arg Asp Glu Ala His Tyr Arg Asp Glu Glu Asn Leu Glu Ile Phe Pro 
             980                985                990
Val Asp Leu Gln Lys Lys Ala Gly Arg Gly Leu Gly Leu Ser Ile Val 
         995                1000                1005
Gly Lys Arg Asn Gly Ser Gly Val Phe Ile Ser Asp Ile Val Lys Gly 
     1010                1015                1020
Gly Ala Ala Asp Leu Asp Gly Arg Leu Ile Gln Gly Asp Gln Ile Leu 
 1025                1030                1035                1040
Ser Val Asn Gly Glu Asp Met Arg Asn Ala Ser Gln Glu Thr Val Ala 
                 1045                1050                1055
Thr Ile Leu Lys Cys Ala Gln Gly Leu Val Gln Leu Glu Ile Gly Arg 
             1060                1065                1070
Leu Arg Ala Gly Ser Trp Thr Ser Ala Arg Thr Thr Ser Gln Asn Ser 
         1075                1080                1085
Gln Ser Ala Glu Cys Thr Gln Gln Leu Ser Ser Leu Leu Arg Ser Cys 
     1090                1095                1100
His His Trp Pro Ala Lys Pro Gly Trp His Lys Lys Ser Phe Arg Ser 
 1105                1110                1115                1120
Phe Pro Glu Lys Phe Arg His Arg Tyr Gly Thr Lys Asp Cys 
                 1125                1130



<210> 7360
<211> 213
<212> DNA
<213> Rattus norvegicus
<308> AI639125
<400> 7360

ttaaaaggg  ccaccaacc  taatggtgg  atttcaaaa  aaggaaggc  tcccaagcc  60
cttcttgtg  tattggggt  tggaatgaa  tgggaagga  aagcttaat  gttggggct  120
aatttggaa  gggaattct  aacaacttg  ggccttttt  ttggtttta  gattcctgg  180
tggcttggg  ggtcaaggg  ttttaattc  ttg  213



<210> 7361
<211> 501
<212> DNA
<213> Rattus norvegicus
<308> AI639130
<400> 7361

ttatggaga  cagcttctg  gttcggctc  cagagaagg  agttccagg  gagcagaac  60
gggggcata  gaagagaca  gagtacctg  agctgctta  aagtgtggg  aaaatgaag  120
tgacactgg  gcatctgtt  ttcatgatg  tactgctgt  gctaggact  ggggtgggg  180
tggggctgg  ccttcacat  gctgctgcc  tcctggaga  tcagccact  gatgagttt  240
ggcccagtg  ctcccagga  acagctgag  ccactgaag  gggacaggg  accaggacc  300
cagaagccc  ggtacttga  aacaaagaa  tggcagtac  tgtctggtc  gaagatact  360
tcctcagtg  agatgaagt  gggggaagc  ggatgctga  agccaagac  ctccttcag  420
gcaagcaag  ctaccttaa  tttgacttg  acatccggg  ctgtaacgt  atgatggcc  480
acaagataa  ggagcacaa  c  501



<210> 7362
<211> 208
<212> PRT
<213> Rattus norvegicus
<308> BAB29898
<400> 7362

Met Lys Val Thr Leu Val His Leu Leu Phe Met Met Leu Leu Leu Leu 
  1               5                  10                  15
Leu Gly Leu Gly Leu Gly Leu Gly Leu Gly Leu His Met Ala Ala Ala 
             20                  25                  30
Val Leu Glu Asp Gln Pro Leu Asn Glu Phe Trp Pro Ser Asp Ser Gln 
         35                  40                  45
Asn Thr Glu Glu Gly Glu Gly Ile Trp Thr Thr Glu Gly Leu Ala Leu 
     50                  55                  60
Gly Tyr Lys Glu Met Ala Gln Pro Val Trp Pro Glu Glu Ala Val Leu 
 65                  70                  75                  80
Ser Glu Asp Glu Val Gly Gly Ser Arg Met Leu Arg Ala Glu Pro Arg 
                 85                  90                  95
Phe Gln Ser Lys Gln Asp Tyr Leu Lys Phe Asp Leu Ser Val Arg Asp 
             100                105                110
Cys Asn Thr Met Met Ala His Lys Ile Lys Glu Pro Asn Gln Ser Cys 
         115                120                125
Ile Asn Gln Tyr Thr Phe Ile His Glu Asp Pro Asn Thr Val Lys Ala 
     130                135                140
Val Cys Asn Gly Ser Leu Val Asp Cys Asp Leu Gln Gly Gly Lys Cys 
 145                150                155                160
Tyr Lys Ser Pro Arg Pro Phe Asp Leu Thr Leu Cys Lys Leu Ala Lys 
                 165                170                175
Pro Gly Gln Val Thr Pro Asn Cys His Tyr Leu Thr Tyr Ile Thr Glu 
             180                185                190
Lys Ser Ile Phe Met Thr Cys Asn Asp Lys Arg Gln Leu Glu Thr Lys 
         195                200                205



<210> 7363
<211> 419
<212> DNA
<213> Rattus norvegicus
<308> AI639132
<400> 7363

ttactatgg  caaaggctg  atgtatttc  gaaaaaaat  attttttct  attagcata  60
ttttcttta  ttaccccca  tttcatagt  gcattttat  ttatacttt  accttgcaa  120
tcagtataa  gtgatccta  atttcaagt  atatgacat  aaaacagaa  tgtgaattc  180
tttataaat  agttttcat  ttctgtaac  tctaattct  catcatcct  atcttctac  240
tgttgatcc  tttttgttc  acaggtggc  acctgtcca  ttccagatg  gcacttagt  300
gacagtggt  tctgaagag  tgactttga  tttgctctt  caatatcta  acgagatgg  360
taatctgat  gatacagag  atttcggaa  acctctaag  cttcatcct  atcaatttt  419



<210> 7364
<211> 747
<212> DNA
<213> Homo sapiens
<308> BG722716
<400> 7364

agcggatga  gaggcgcac  ctggaaaac  ggaacgctc  aacgaaaca  ctgcaaaca  60
ctgtctcaa  tgtggagaa  cattttgga  aactgtgcc  aatcttcgc  gcctatgtg  120
ggaaaactg  caggctgag  gacaaagca  acctcctgg  gaatgaaat  aacgcgtat  180
ctgctacag  gaccccgct  ttaaagctg  gcctgatga  ctttgcaga  gagtttgcc  240
aacttcagg  ttatcgaca  gcagaggtt  aaagacttg  agccaaagt  gttgaaccc  300
tgaaaactt  tgggaccat  gtgaaaatg  aacgggatg  cctcaaagc  acactcaca  360
caaggaatc  agaagctaa  caattaact  agttagaaa  aacacgtca  cgaaaccca  420
ctgatcgac  tgttatttc  cagaaacgg  attacagag  gctgcaatg  atgctagcc  480
aacaagtcg  catctggag  aaactatta  caactttga  aggcagaaa  tgaaggata  540
aaagactat  ttttctgaa  ttatcacaa  cgaaatgtt  tttcacggc  aagctttag  600
ggtctacac  gctgcctac  agaatatac  aaacattga  gaagatgaa  atttagagg  660
tttccgaaa  tctctgtat  caccagatt  ttcatctcg  ttagatatt  taagagcaa  720
ttcaaagtc  cctcttcag  gatcacg  747



<210> 7365
<211> 383
<212> DNA
<213> Rattus norvegicus
<308> AI639139
<400> 7365

ttgattttt  aaaaagcct  tttatttga  tattcattt  attaactgt  cataatcaa  60
attccttaa  agggaagga  cccttttcc  tggtgacat  ggtcaaact  catgtacgg  120
tccaaggcg  caaacagct  tcgagcaca  gatcttctc  agtaccaag  attttcccg  180
tcctatgct  agaccatct  agaacaagg  cagactgta  ttagaagct  aagtgttcc  240
tgaagagat  acgacacca  tcggcatgg  gaacctaat  ttcaggcac  tgcccctgc  300
tcagtgttc  ctaaattca  gcaccctcc  cctgtcagc  acgaccgga  ctggggtga  360
ctgtgactc  tggctggga  ctt  383



<210> 7366
<211> 383
<212> DNA
<213> Rattus norvegicus
<308> AI639139
<400> 7366

ttgattttt  aaaaagcct  tttatttga  tattcattt  attaactgt  cataatcaa  60
attccttaa  agggaagga  cccttttcc  tggtgacat  ggtcaaact  catgtacgg  120
tccaaggcg  caaacagct  tcgagcaca  gatcttctc  agtaccaag  attttcccg  180
tcctatgct  agaccatct  agaacaagg  cagactgta  ttagaagct  aagtgttcc  240
tgaagagat  acgacacca  tcggcatgg  gaacctaat  ttcaggcac  tgcccctgc  300
tcagtgttc  ctaaattca  gcaccctcc  cctgtcagc  acgaccgga  ctggggtga  360
ctgtgactc  tggctggga  ctt  383



<210> 7367
<211> 383
<212> DNA
<213> Rattus norvegicus
<308> AI639139
<400> 7367

ttgattttt  aaaaagcct  tttatttga  tattcattt  attaactgt  cataatcaa  60
attccttaa  agggaagga  cccttttcc  tggtgacat  ggtcaaact  catgtacgg  120
tccaaggcg  caaacagct  tcgagcaca  gatcttctc  agtaccaag  attttcccg  180
tcctatgct  agaccatct  agaacaagg  cagactgta  ttagaagct  aagtgttcc  240
tgaagagat  acgacacca  tcggcatgg  gaacctaat  ttcaggcac  tgcccctgc  300
tcagtgttc  ctaaattca  gcaccctcc  cctgtcagc  acgaccgga  ctggggtga  360
ctgtgactc  tggctggga  ctt  383



<210> 7368
<211> 383
<212> DNA
<213> Rattus norvegicus
<308> AI639139
<400> 7368

ttgattttt  aaaaagcct  tttatttga  tattcattt  attaactgt  cataatcaa  60
attccttaa  agggaagga  cccttttcc  tggtgacat  ggtcaaact  catgtacgg  120
tccaaggcg  caaacagct  tcgagcaca  gatcttctc  agtaccaag  attttcccg  180
tcctatgct  agaccatct  agaacaagg  cagactgta  ttagaagct  aagtgttcc  240
tgaagagat  acgacacca  tcggcatgg  gaacctaat  ttcaggcac  tgcccctgc  300
tcagtgttc  ctaaattca  gcaccctcc  cctgtcagc  acgaccgga  ctggggtga  360
ctgtgactc  tggctggga  ctt  383



<210> 7369
<211> 411
<212> DNA
<213> Rattus norvegicus
<308> AI639151
<400> 7369

ttaataatg  aagatgcat  tttatttct  caaaagcaa  gtatgatac  gaacataaa  60
gaacaatta  agatttacc  attaaaata  acagattct  actgaaaag  aatagggta  120
ttaaaaaag  tgacaaagg  tgttaatct  tttttatta  tatcatttt  acatatttt  180
gaacctcac  taattttga  aaataactc  tacaaaatt  tgcaaaaag  acaagaatg  240
ctggtaaac  aacagtctg  attttccaa  aagaatttt  acaacatgc  attcttaag  300
cagcatcct  tttacaagg  aatcctttt  ctcatcaaa  cttctgctg  aaagaatag  360
ctaagcaag  ctggcttct  ccattaacg  cttttgtct  tcctgtctg  t  411



<210> 7370
<211> 725
<212> PRT
<213> Rattus norvegicus
<308> NP_032917
<400> 7370

Met Ala Val Ala Val Arg Ala Leu Gln Glu Gln Leu Glu Lys Ala Lys 
  1               5                  10                  15
Glu Ser Leu Lys Asn Val Asp Glu Asn Ile Arg Lys Leu Thr Gly Arg 
             20                  25                  30
Asp Pro Asn Asp Val Arg Pro Ile Gln Gly Thr Leu Leu Ala Leu Ser 
         35                  40                  45
Gly Pro Gly Gly Gly Arg Gly Arg Gly Ser Leu Leu Leu Arg Arg Gly 
     50                  55                  60
Phe Ser Asp Ser Gly Gly Gly Pro Pro Ala Lys Gln Arg Asp Leu Glu 
 65                  70                  75                  80
Gly Ala Val Ser Arg Leu Gly Gly Glu Arg Arg Thr Arg Arg Glu Ser 
                 85                  90                  95
Arg Gln Glu Ser Asp Pro Glu Asp Asp Asp Val Lys Lys Pro Ala Leu 
             100                105                110
Gln Ser Ser Val Val Ala Thr Ser Lys Glu Arg Thr Arg Asp Leu Ile 
         115                120                125
Gln Asp Gln Asn Met Asp Glu Lys Gly Lys Gln Arg Asn Arg Arg Ile 
     130                135                140
Phe Gly Leu Leu Met Gly Thr Leu Gln Lys Phe Lys Gln Glu Ser Thr 
 145                150                155                160
Val Ala Thr Glu Arg Gln Lys Arg Arg Gln Glu Ile Glu Gln Lys Leu 
                 165                170                175
Glu Val Gln Ala Glu Glu Glu Arg Lys Gln Val Glu Asn Glu Arg Arg 
             180                185                190
Glu Leu Phe Glu Glu Arg Arg Ala Lys Gln Thr Glu Leu Arg Leu Leu 
         195                200                205
Glu Gln Lys Val Glu Leu Ala Gln Leu Gln Glu Glu Trp Asn Glu His 
     210                215                220
Asn Ala Lys Ile Ile Lys Tyr Ile Arg Thr Lys Thr Lys Pro His Leu 
 225                230                235                240
Phe Tyr Ile Pro Gly Arg Met Cys Pro Ala Thr Gln Lys Leu Ile Glu 
                 245                250                255
Glu Ser Gln Arg Lys Met Asn Ala Leu Phe Glu Gly Arg Arg Ile Glu 
             260                265                270
Phe Ala Glu Gln Ile Asn Lys Met Glu Ala Arg Pro Arg Arg Pro Ser 
         275                280                285
Met Lys Glu Lys Glu His Gln Val Val Arg Asn Glu Glu Gln Lys Ala 
     290                295                300
Glu Gln Glu Glu Gly Lys Val Ala Gln Arg Glu Glu Glu Leu Glu Glu 
 305                310                315                320
Thr Gly Asn Gln His Asn Asp Val Glu Val Glu Glu Ala Gly Glu Glu 
                 325                330                335
Glu Glu Lys Glu Ala Gly Ile Val His Ser Asp Ala Glu Lys Glu Gln 
             340                345                350
Glu Glu Glu Glu Gln Lys Gln Glu Met Glu Val Lys Ile Glu Glu Glu 
         355                360                365
Ala Glu Val Arg Glu Gly Glu Lys Gln Gln Asp Ser Gln Pro Glu Glu 
     370                375                380
Val Met Asp Val Leu Glu Met Val Glu Ser Val Lys His Val Ile Ala 
 385                390                395                400
Glu Gln Glu Val Met Glu Thr Asn Gln Val Glu Ser Ile Glu Pro Ser 
                 405                410                415
Glu Asn Glu Thr Ser Lys Glu Leu Glu Pro Glu Met Glu Phe Asp Val 
             420                425                430
Glu Pro Asp Lys Glu Cys Lys Ser Leu Ser Pro Gly Lys Glu Asn Ile 
         435                440                445
Asn Ser Gln Glu Val Glu Lys Glu Ser Glu Glu Lys Glu Glu Lys Glu 
     450                455                460
Glu Lys Glu Pro Glu Pro Gln Pro Glu Pro Val Ala Gln Pro Gln Pro 
 465                470                475                480
Pro Pro Gln Pro Leu Pro Gln Ser Gln Pro His Ser Gln Pro His Ser 
                 485                490                495
Gln Pro Gln Pro Val Leu Gln Ser Gln Pro Leu Cys Gln Pro Glu Thr 
             500                505                510
Leu Pro Leu Ala Val Leu Gln Pro Pro Pro Gln Val Ile Gln Glu Gln 
         515                520                525
Gly Asn Leu Leu Pro Glu Arg Lys Asp Phe Pro Leu Glu Ser Ile Lys 
     530                535                540
Leu Pro Glu Val Ser Val Glu Pro Val Leu Thr Val His Ser Glu Asn 
 545                550                555                560
Lys Ser Lys Asn Lys Thr Arg Ser Arg Ser Arg Gly Arg Ala Arg Asn 
                 565                570                575
Lys Thr Ser Lys Ser Arg Ser Arg Ser Ser Ser Ser Ser Ser Ser Ser 
             580                585                590
Ser Ser Ser Thr Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Gly Ser 
         595                600                605
Ser Ser Ser Arg Ser Ser Ser Ser Ser Ser Ser Ser Thr Ser Gly Ser 
     610                615                620
Ser Ser Arg Asp Ser Ser Ser Ser Thr Ser Ser Ser Ser Glu Ser Arg 
 625                630                635                640
Ser Arg Ser Arg Gly Arg Gly His Asn Arg Asp Arg Lys His Arg Arg 
                 645                650                655
Ser Met Asp Arg Lys Arg Arg Asp Thr Ser Gly Leu Glu Arg Ser His 
             660                665                670
Lys Ser Ser Lys Gly Gly Ser Ser Arg Asp Arg Lys Gly Ser Lys Asp 
         675                680                685
Lys Ser Ser Arg Pro Asp Arg Lys Arg Ser Ile Ser Glu Ser Ser Arg 
     690                695                700
Ser Gly Lys Arg Ser Ser Arg Ser Glu Arg Asp Arg Lys Ser Asp Arg 
 705                710                715                720
Lys Asp Lys Arg Arg 
                 725



<210> 7371
<211> 11787
<212> DNA
<213> Homo sapiens
<308> AF195139
<400> 7371

tctagatga  attcttgcc  tcatcacta  catcaagaa  aaggagtcc  agtccacca  60
acaagtcaa  aagtaagta  atggccaat  tatcaaagt  gacttctcc  accacaata  120
catgaggct  ttaaagtac  tttctggat  gaaaggaaa  ttatttaat  aggacctac  180
aactattga  cacagcatc  tacttatcc  tctccataa  gttaaattg  caaggctcc  240
aggaataga  cctatggaa  caaggacag  gagtgtggt  tgtgtgtgt  tgtgtgtgt  300
tgtgtgtgt  ttttgagac  gagttttgc  cttgttgcc  aggctggag  gcaatggca  360
tatctcagc  cactgcaac  ccgcctccc  ggttcaagt  attctcctg  ctcagcttc  420
cgagtaggt  ggattacag  catgcacca  caagcccag  tcattttgt  tttttagta  480
agacggggt  tctccatgt  ggtcaggct  atctcgaac  cgtgacctc  ggtgatccg  540
ctgcctcgg  ctcccaaag  gctgggatt  cagacttga  ccactgtgc  cagctgtgt  600
tgttttgtt  tgtttgaga  agagtctca  tgttgccca  gccagagtg  agtggcatg  660
tcttggctc  ctgcatgca  cctccacct  ccgggctca  gcaattctg  ctcagcctt  720
caagcagct  acactacag  cacttgcca  catgcagga  taattttgt  tttttagta  780
agacagggt  tcatcatgt  ggccaggct  gtcttgaac  cccaatctc  agtgatccg  840
ccaccaagg  ctcccaaaa  cctgggatt  ccgggccga  catacatgc  aacattctt  900
cacttgctg  acacgctct  ctattatca  actctcatg  ctcaggtac  gcctaaggt  960
gtacacaga  ctgtaataa  atcaatgag  ctaagtatg  tcacaatca  aattagata  1020
ttgtcaatc  tcatcccca  tattcatct  tacattttt  tctcctata  tacttcccg  1080
tttctaaca  gctatacta  ttatttatt  atttattta  ttttgagac  gagtctcac  1140
gctgcccag  ctagagtgc  gtggtgtga  gacagctca  tgcagtctc  aactcctgg  1200
ctcaaacaa  catcccgcc  cagcctctc  agtacaatt  ttaaaattt  tatttttag  1260
gacaggatc  ttgctatgt  gcccaggct  gtcttaact  ctgggctgt  gcgattctc  1320
cacctcagt  tcccaagta  ctgggatta  aggcacaat  cactggact  gctcagaga  1380
atctttatt  tacactgat  tacccaagt  cctagaata  cacctggca  atagtgggc  1440
ctcagtatt  gttgaacta  tgaatgatc  ttgctcctt  ggaagccta  aaaccccac  1500
gaagcagga  tcacaacta  cttgttcta  gctttattt  caaacccta  cttactgct  1560
atacacaat  gaagctcta  aagattgct  gattaaagt  gtagcttga  ttaattaat  1620
cactgggcc  actaattct  tgtacacgg  agatagatg  ctggctgag  ttatttaaa  1680
cattgtttc  gtgggaaag  gttttgttt  tttgtttgt  tgggacgga  tctcactct  1740
tcgcacagg  tagagtgca  tggtgcaat  tcggctcac  gcaacctcc  catcccggg  1800
tcccgagta  ctgggatta  aggcgtaca  caccactcc  agctaattt  tgtattttt  1860
gtaaaggcg  ggtttcccc  tgttggcca  gctggtctc  aactcctgg  ctcaagtga  1920
ccacctgcc  cagcctccc  aagtgctgg  attacgggc  tgngncact  tgcctggcc  1980
gtgaaaaaa  gttttctga  cttcaattt  tatatatat  tatagaata  aactagttc  2040
tacattggc  gtgcaggta  ggcagaacc  gaagcggga  aacacacac  gacaccact  2100
acaacaggg  cgctccctt  ggtctggtc  taaccagct  taggccagg  gaagaggct  2160
actcggcca  gactgcgtg  ctgtctcgc  attgctttc  tttctctag  atagatgct  2220
agcgtctaa  cagagactg  ttctcaact  gcgtgacca  aggacagtt  tattatctc  2280
agtctcaat  tccttatca  taataacag  cattttatc  acactttca  tttgtgaga  2340
ataaggcat  tagacggtt  cacagaggg  cgggaacaa  atcaacccc  aacaaacgt  2400
agccattat  actaatgac  tttactagt  ttcattttt  tcttccctc  tctcacttt  2460
acctaatca  gctgggcgt  gtggctcac  ctgtaatcc  agcaccctg  gaggtcgag  2520
caggcgaat  acctgaggt  aggagttcg  gaccagcct  cccaacatc  tggaatccg  2580
tctctaata  tacaaaaat  agccaggcg  gttgcgcgc  cctgtagtc  caggtactc  2640
ggaggctga  gcaggagaa  cgcttgaac  cgggaggag  aggttgcag  gagccgaga  2700
ggtgccact  cactccagc  tggacgaca  agcgagact  cgtgtgaaa  aaaaaaaat  2760
aacctaata  aggaaagca  gcgcccacc  cctctctga  catgcgcac  aacagaata  2820
ccgcgccct  tcctaatta  atcattaac  aaggtgagg  taaggaaga  aaggaggct  2880
ggctaagtc  cactctgat  tgatcacgt  aaaacggtg  aaggcacat  acatcatag  2940
ttaaaaggc  tagaaaact  cgcgctccc  ttgccagaa  tgcagactc  cgagcctaa  3000
tctccgaga  ctcagggat  gtgaaaccc  ccccgactc  gcgctagca  cgggatcca  3060
gcacccgca  ctaactggg  agggagatg  ctgcctggc  gacttttca  tggctcaga  3120
tcacaaagg  tgcaggttc  tcccccttc  ggtcgctga  tggttgagg  cggaagaca  3180
cgctcatcg  cattggctg  gcccggctg  cagtccttt  gcgcctcgg  ggcgcggca  3240
agcccggct  ggcctgtaa  gcagtctca  gcctgccgc  gggagaaga  ggcggtcgc  3300
gtgagaact  tgcaggaac  gctggaaaa  gccaaagag  gtcttaaga  cgtggatga  3360
aacattcgc  agctcaccg  gcgggatcc  aatgacgtg  ggtaagggc  taacgggaa  3420
tcggaactc  gagctcgga  aggcagccc  caggtcggg  tgaattggg  gcggggagg  3480
cggccagcc  taagaagac  ggaacctcg  ggcctgttc  cggggcggc  ggtaaaacc  3540
tgttgtcgc  gaggtggag  ggccccagg  cccctccgt  gagcgctgg  ctcaggtcc  3600
tgaggaagg  gagcgaggc  tgggtgcgc  ggcatgctt  cttggcctg  gagaagacc  3660
ggactgctg  ttcccgctc  cggccctgc  ggcccggaa  tgcagcaca  agccccttc  3720
cgctccggc  gacacccgg  ccgttgctg  ccccgagac  ctgccggac  caacaagcc  3780
ccttacccc  acttcctgt  cacgtgcag  ctcctcggg  atggcggga  ggggacctg  3840
tccaggctt  ttaatgtgt  ggggcatcg  ggtgaatat  atttctgtg  cacaggtcc  3900
ggagaaacg  ggaagttaa  tgaaatagt  cttcctgtc  tgtttcaga  atttagatt  3960
atttgaaac  atctttttg  aacttttgt  attttttct  cttatgatc  acatctctg  4020
aagtatttg  gtgcgactg  gtgtgtcta  atatgattt  gcactgatt  gtaaatctt  4080
tacaggccc  tccaagcca  attgctggc  ctttctggt  ctggtggag  tagaggacg  4140
ggtagttta  tactgaggt  agatttcct  tggacttta  tcatgctga  actactggt  4200
ctttactaa  tatgttggt  tgaacaaaa  ctgtgataa  atcaataac  cagtgtttg  4260
cgtctttgt  ttgtttaat  ttgtataga  tagatttct  tataaaagt  gttatcctg  4320
aaaactgga  gttgaagaa  atattaagt  taccaattt  gagtgaact  aattcttat  4380
aagtaacac  ataaaagca  tttggaatg  atgcccgtt  aaggctact  tagttggaa  4440
gatttttga  agtttaacc  tattctctt  tcaaatgga  ataccattt  tcttgtatt  4500
caagtgttt  atgttgaac  ttttaaatt  caggcgtgg  ttctcagat  gtggaggag  4560
acccccagc  aaacagaga  accttgaag  ggcagtcag  aggtaggtt  aaaaaaaga  4620
tcctgaagg  ttctttagt  tctgaggta  cacacaaat  taaatattt  ttaacaata  4680
ttctgtttc  gcaatatta  aattgagtg  tatgccact  cctgccccc  ccaagttct  4740
ttggtattt  actgaacag  tgactatca  ttccctcaa  acgcagttc  gcactcatg  4800
taagctaaa  tttatccaa  taaaggtca  gtgaagagt  aaattggaa  aattgtcaa  4860
tagtaccat  ttttctgac  tgtacttga  aaacttaac  agtttgaaa  acttagaaa  4920
tacaggaga  caaaattgg  ttgggcgtt  gttcacaca  tgtagtatc  tttctctgc  4980
ggaggaaag  ataaaatgg  atggagact  gatagaaca  agcttctgg  aacgagtcc  5040
agaagagag  gcatttgcc  ttggtgtgc  gttacataa  tacctcagt  gtcatttaa  5100
ttaattttt  gccaggcac  gtggctcat  cctgtaatc  cagcacttt  ggaagccaa  5160
accagcaga  cacttgagc  caggagttg  agaacagcc  agatacatg  tgaaatccc  5220
tccctacaa  aagtacaaa  aagttaccc  ggcatgctg  ctcacgcct  tagtcccag  5280
tgcttggga  gatgaggca  gaggatcac  tgagcctgg  aggtcgagg  tgcagtgaa  5340
cgtggtggc  ccactgcac  tcagcctgg  tggtatagt  aaaccctgt  tcaaaaaaa  5400
taatatttt  tatgacagg  tgggcgggg  gcgtcggac  agaagagaa  cacgccagg  5460
aagcgaccc  gaggatgat  atgttaaaa  ggtattgag  ttgaaagaa  ttaaatgaa  5520
gtagtacct  cactttact  catttaaaa  cacaccact  atatgctag  taaattact  5580
agattttct  tttctgcag  cagcattgc  gtcttcagt  gtagctacc  ccaaagagc  5640
cacacgtag  gaccttatc  aggatcaaa  tatggatga  aagggaaag  aaaggtatt  5700
ccctggggg  aaaaaactc  agtgaaata  tgcagttat  aggaaatca  gggattgtt  5760
aagcatcct  tagtatttc  tagaaaatc  tgggtttaa  tgaaatgga  cctgttgac  5820
gtaaatttt  ttattctgt  ctttaggaa  cggcgaata  ttggcttgt  gatgggtac  5880
cttcaaaaa  ttaaacaag  atccactgt  gctactgaa  gggtattta  ccaagtttt  5940
ttttgcatc  tatatttaa  ttatcaaag  agtagatta  tgttttttt  aaaaaatcc  6000
taaagctct  ttaagacct  actgtaaac  tgaaacaaa  ccaagtaaa  acttggttt  6060
acttcttat  gaacagctt  acttaaaca  gtgttggat  taacagttg  tgatatcat  6120
gctaatagt  tgaaattta  atatgtgaa  aaaaaaagc  tcaagtctc  atttcctta  6180
agacaaatt  cagtcagta  caagtgcta  gttctagtt  gttggtatc  tgaattgaa  6240
atgtgaagc  gccaggtgc  gtgctcatg  ctgtaatcc  agcactttg  gaggctgag  6300
caggtggat  acctgaggt  agaagtttt  cgagaccag  ctggccaac  tggtgaaac  6360
ctgtcttta  taaaaatac  aaattagcc  cctgtggtg  atgcgcctg  aatccccag  6420
tatttggga  gcggaggca  gagaatcac  tgaaccctg  aggtgaggt  gcaatgagc  6480
aagatcaca  tattgtacc  cagcctggg  aacaggcgc  aaactccat  tcaaaaaaa  6540
aaaaaatgt  aaggatatg  agatacctt  tttttttct  tttcttttt  tttgtagag  6600
tggggtttt  tcatgttgc  caggctggt  tgagctcaa  gcaatccac  cacctcagc  6660
tcccagagt  ctgggatga  aggtgtgag  cactgtgtt  ggaatgcag  tacctttac  6720
tagtgaaaa  aaaaaaaaa  aaaattttt  tttgagatg  agtttggct  ttcttgctc  6780
ggctggagt  tagtggcgt  atctcagct  actgcaacc  ccgcctctg  ggttcaagt  6840
atttctcct  cttcggcct  ccaagtagc  gggattata  gtgcgtgca  ccacgcctg  6900
taatttttt  gtgttttta  tagagatgg  ggtgttggc  tctgacttc  gatgatcta  6960
ctgcctcta  tgtttcacg  aattagtat  tgtaataac  ttttatcat  attgaactg  7020
aatcatata  accttttgt  gtaactatt  caacacgta  gtattaaag  aggctactt  7080
acttttagc  aaagcggcg  caggaaatt  aacaaaaac  tgaagttca  gcagaagaa  7140
agagaaagc  ggttgaaaa  gaaaggaga  aactgtttg  agagaggcg  gctaaacag  7200
cagaactgc  gcttttgga  cagaaagtt  agcttgcgc  gctggtgag  ggtaatttg  7260
aattctaag  ttggtaatc  tttgtgttt  caaaagcac  gacccttta  cttttcttt  7320
gcaagaaga  tggaatgaa  ataatgcca  aataattaa  tatataaga  ctaagacaa  7380
gccccattt  ttttatatt  ctggaagaa  gtgtccagc  acccaaaaa  taatagaag  7440
gtcacagag  aaaatgaac  gtaagtatg  gaagaggtc  attgaattg  tcatagtgg  7500
taaggtaat  tgttcatat  cacacgttt  ttttctaaa  taattatga  tcagtgatt  7560
gtttgctgt  tttggtttt  ttttttaaa  aagataata  gatattcta  gccgggcgt  7620
gtggctcac  cctgtaatc  cagcacttt  ggaggctga  gcaggcaga  catgaggtc  7680
ggagatcga  accatcccg  ctaacatgg  gaacccgtc  ctagtctct  ctaaataca  7740
aaaaaatta  ctgggcatg  tggtgggca  ctgtaattc  agctacttg  caggctgag  7800
caggagaat  acttgaacc  gggaggcag  agttgcagt  agccgagat  acgccactg  7860
actccagcc  gggcaacag  gctagactc  atctcaaaa  aaaaaaaaa  atacattct  7920
agatgctgg  gagtttgta  tataggaat  tttgtatca  gatggagtt  aatgtgaaa  7980
ttatagaca  tgcttatgc  tctgtattc  ttaagcatt  gtgtaaaat  acttttttt  8040
gcatgctat  attgttctg  taaaatgct  ataagacaa  tgtgaaaac  aactcagtt  8100
ctagatgga  aacacatgg  aggatagac  ctgctaaga  gatgattta  ctctttggg  8160
ctcagaaaa  ttaatatat  tgattttat  ccaaaactg  ttctgtttt  cagaagttt  8220
atttttcat  agacataaa  attgatctg  tttcttcat  agttagaaa  tgtgcagtt  8280
tgtctgcca  aatttctag  atgtagatt  cccatggat  tttgctttt  taattttat  8340
tcagtttgt  gttacttaa  tgccataat  ttttgtcat  actttacaa  aacaaattc  8400
gatgaagct  aatgacaat  tgtgaccag  tataaaatt  tggctttga  ttttcttaa  8460
cggtaaatt  tacacatgt  aatttttat  ctttagctt  atttgaagg  agacgcatc  8520
aatttgcag  acaaataaa  aaaatggag  ctaggccta  aagacaatc  atgaaggaa  8580
aagagcatc  ggtggtgcg  aatgaagaa  agaaggcgg  acaagaaga  ggtaaggtg  8640
ctcagcgag  ggaagagtt  gaggagaca  gtaatcagc  caatgatgt  gaaatagag  8700
aagcaggag  ggaagagga  aaggaaata  cgattgttc  tagtgatgc  gagaaagaa  8760
aggaggagg  agaacaaaa  caggaaatg  aggttaaga  ggaggagga  actgaggta  8820
gggaaagtg  gaagcagca  gatagtcag  ctgaagaag  tatggatgt  ctagagatg  8880
ttgagaatg  caaacatgt  attgctgag  aggaggtaa  ggaaactaa  cgagttgaa  8940
gtgtagaac  ttcagaaaa  gaagctagc  aagaattgg  accagaaat  gaatttgaa  9000
ttgagccag  taaagaatg  aaatccctt  ctcctggga  agagaatgt  agtgcttta  9060
acatggaaa  ggagtctga  gaaaaagaa  aaaaagaat  tgagcccca  cctgagcct  9120
tggctcaac  tcagcctca  tctcagccc  agcttcagc  tcaatccca  tcccaacca  9180
tactccagt  ccagcctcc  tctcagcct  aggatttgt  attagctgt  ttacagcca  9240
caccccaag  tactcagga  caagggcat  tactacctg  gaggaagga  tttcctgta  9300
agtctgtaa  actcactga  gtaccagta  agccagtct  gacagtaca  ccagagagc  9360
agagcaaaa  caaaactag  agcagaagt  gaggtcgag  tagaaataa  acaagcaag  9420
gtagaagtc  aagcagtag  agtagcagt  ctagtagca  ttcaaccag  agcagcagt  9480
gaagtagtt  cagcagtgg  agtagtagc  gtcgcagta  ttccagtag  agctccagt  9540
caagtggca  cagcagcag  gatagtagc  gtagcacta  tagtagtag  gagagtaga  9600
gtcggagta  gggccgggg  cataataga  atagaaagc  cagaaggag  gtggatcgg  9660
agagaaggg  tacttcagg  ctagaaaga  gtcccaaat  ttcaaaagg  ggtagtagt  9720
gagatacaa  aggatcaaa  gataagaat  cccggtccg  cagaaagag  tctatatca  9780
agagtagtc  atcaggcaa  agatcttca  gaagtgaaa  agaccgaaa  tcagacagg  9840
aagacaaaa  gcgttaatg  aagaagcca  gctttctta  ccattcttt  cagcagaag  9900
tttcttgat  aaaaaggat  acctttcct  gtaaagagg  tgctgcctt  agaattgca  9960
gttgtaaaa  atctttttg  aagatacag  ctgtttgtt  accagacat  cttgtactt  10020
ttgcataat  ttgtaagag  tatttatca  aattatgtg  ggttccaaa  tatgtaaaa  10080
tgataataa  aaaaaaaga  taacatccc  tgtcatctt  tttaaatat  ctatactct  10140
cagtaagaa  ctgtatatt  taataggca  atctttaag  ctgttccct  caattctgt  10200
tcatacatt  cttttgtag  aataaatgt  tgtttattt  attattttt  ggatgtcct  10260
gttgacact  gtataataa  tatcctctt  atcattttc  gcttttaac  ctagatact  10320
cacgtgatt  gaatgtttt  gaaggtttc  tcgttttta  ttgccttgg  cagttttta  10380
ttgtcagag  cagagcttt  cagctttga  ggggaacag  tctctttaa  atcatttgc  10440
attttctat  ctcccttgt  attttaatc  aagcatttt  ccccgtttc  catatttta  10500
ccatatgtt  ggtagataa  taaacagta  gatctggtt  gcattttct  cctgatgat  10560
ggagcgtca  tcttttgtc  tcatggtta  ttgtgtgat  taacataca  ctgttaaag  10620
aaatcactt  tttctaggg  agggaggta  aaaagtatc  ttcaaactt  gtttttgag  10680
ttgtgtctt  tcttaactt  gtgttggct  taacttaaa  atgctgata  gtgttttca  10740
gaattttgt  taaggaagt  ttgtatgga  gtccacaaa  tgaaggaag  tcatctagg  10800
tttaatatg  aagcaagat  acacacaag  gtaccaagt  attattaac  ttgttgttt  10860
acaaatttg  atgaacttg  agtatctgt  ggccattac  atacatgtg  aaataaatg  10920
ggcttagac  tgtgtgact  cttaagact  gtacttgta  taactttct  atgctttat  10980
caagagagc  cttaaattg  atccttcct  gagtttaac  ctgtagctt  agccttgac  11040
ttgaatatt  attttgcct  cccttgaca  gtaaatggt  acagtgaaa  tgtgaagaa  11100
tatttccag  tagtttttg  gtgtatata  ctcacttgt  taagtggat  tgttaaaag  11160
tctcttttt  aaaatcctt  tattggagt  attattaaa  cagtaaatg  atagagctt  11220
gcacagcaa  ctgtatcca  gagccagtt  caccactag  accttcatc  gtggcttat  11280
cagcaaaat  tttcatttc  tgtgtgccc  ggcaggaaa  aggttggta  atagtgaat  11340
aaagggatg  tcataaaat  taacctggt  aaaaagcac  ttatttgat  acagtttgt  11400
tgcactaaa  tcctttata  aaattaagt  ttgtctact  atttgtacc  ggaaaatct  11460
aacaatatt  atgttgctt  cagaaaagg  tagtattgg  ttgaagctc  acgatagga  11520
gggtagtaa  gggggtata  tgaatgctt  aggggaaag  aattttcag  aatttcagt  11580
aagcgctac  gatcatagt  tgtgaaagg  atttttctt  tatggaatg  ttgatgaat  11640
tgcatgtca  ccttgtgca  gggccattt  aatcttttt  ttttttttt  ttttctcgg  11700
gacagggtc  tagtctgtc  cccaggctg  agtgcagtg  cacaaacaa  ctgactgca  11760
cctcgacct  ctgggttca  gggatcc  11787



<210> 7372
<211> 717
<212> PRT
<213> Homo sapiens
<308> AAG33941
<400> 7372

Met Ala Val Ala Val Arg Thr Leu Gln Glu Gln Leu Glu Lys Ala Lys 
  1               5                  10                  15
Glu Ser Leu Lys Asn Val Asp Glu Asn Ile Arg Lys Leu Thr Gly Arg 
             20                  25                  30
Asp Pro Asn Asp Val Arg Pro Ile Gln Ala Arg Leu Leu Ala Leu Ser 
         35                  40                  45
Gly Pro Gly Gly Gly Arg Gly Arg Gly Ser Leu Leu Leu Arg Arg Gly 
     50                  55                  60
Phe Ser Asp Ser Gly Gly Gly Pro Pro Ala Lys Gln Arg Asp Leu Glu 
 65                  70                  75                  80
Gly Ala Val Ser Arg Leu Gly Gly Glu Arg Arg Thr Arg Arg Glu Ser 
                 85                  90                  95
Arg Gln Glu Ser Asp Pro Glu Asp Asp Asp Val Lys Lys Pro Ala Leu 
             100                105                110
Gln Ser Ser Val Val Ala Thr Ser Lys Glu Arg Thr Arg Arg Asp Leu 
         115                120                125
Ile Gln Asp Gln Asn Met Asp Glu Lys Gly Lys Gln Arg Asn Arg Arg 
     130                135                140
Ile Phe Gly Leu Leu Met Gly Thr Leu Gln Lys Phe Lys Gln Glu Ser 
 145                150                155                160
Thr Val Ala Thr Glu Arg Gln Lys Arg Arg Gln Glu Ile Glu Gln Lys 
                 165                170                175
Leu Glu Val Gln Ala Glu Glu Glu Arg Lys Gln Val Glu Asn Glu Arg 
             180                185                190
Arg Glu Leu Phe Glu Glu Arg Arg Ala Lys Gln Thr Glu Leu Arg Leu 
         195                200                205
Leu Glu Gln Lys Val Glu Leu Ala Gln Leu Gln Glu Glu Trp Asn Glu 
     210                215                220
His Asn Ala Lys Ile Ile Lys Tyr Ile Arg Thr Lys Thr Lys Pro His 
 225                230                235                240
Leu Phe Tyr Ile Pro Gly Arg Met Cys Pro Ala Thr Gln Lys Leu Ile 
                 245                250                255
Glu Glu Ser Gln Arg Lys Met Asn Ala Leu Phe Glu Gly Arg Arg Ile 
             260                265                270
Glu Phe Ala Glu Gln Ile Asn Lys Met Glu Ala Arg Pro Arg Arg Gln 
         275                280                285
Ser Met Lys Glu Lys Glu His Gln Val Val Arg Asn Glu Glu Gln Lys 
     290                295                300
Ala Glu Gln Glu Glu Gly Lys Val Ala Gln Arg Glu Glu Glu Leu Glu 
 305                310                315                320
Glu Thr Gly Asn Gln His Asn Asp Val Glu Ile Glu Glu Ala Gly Glu 
                 325                330                335
Glu Glu Glu Lys Glu Ile Ala Ile Val His Ser Asp Ala Glu Lys Glu 
             340                345                350
Gln Glu Glu Glu Glu Gln Lys Gln Glu Met Glu Val Lys Met Glu Glu 
         355                360                365
Glu Thr Glu Val Arg Glu Ser Glu Lys Gln Gln Asp Ser Gln Pro Glu 
     370                375                380
Glu Val Met Asp Val Leu Glu Met Val Glu Asn Val Lys His Val Ile 
 385                390                395                400
Ala Glu Glu Glu Val Met Glu Thr Asn Arg Val Glu Ser Val Glu Pro 
                 405                410                415
Ser Glu Asn Glu Ala Ser Lys Glu Leu Glu Pro Glu Met Glu Phe Glu 
             420                425                430
Ile Glu Pro Asp Lys Glu Cys Lys Ser Leu Ser Pro Gly Lys Glu Asn 
         435                440                445
Val Ser Ala Leu Asp Met Glu Lys Glu Ser Glu Glu Lys Glu Glu Lys 
     450                455                460
Glu Ser Glu Pro Gln Pro Glu Pro Val Ala Gln Pro Gln Pro Gln Ser 
 465                470                475                480
Gln Pro Gln Leu Gln Leu Gln Ser Gln Ser Gln Pro Val Leu Gln Ser 
                 485                490                495
Gln Pro Pro Ser Gln Pro Glu Asp Leu Ser Leu Ala Val Leu Gln Pro 
             500                505                510
Thr Pro Gln Val Thr Gln Glu Gln Gly His Leu Leu Pro Glu Arg Lys 
         515                520                525
Asp Phe Pro Val Glu Ser Val Lys Leu Thr Glu Val Pro Val Glu Pro 
     530                535                540
Val Leu Thr Val His Pro Glu Ser Lys Ser Lys Thr Lys Thr Arg Ser 
 545                550                555                560
Arg Ser Arg Gly Arg Ala Arg Asn Lys Thr Ser Lys Ser Arg Ser Arg 
                 565                570                575
Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Ser Ser Ser Ser 
             580                585                590
Gly Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Arg Ser Ser Ser Ser 
         595                600                605
Ser Ser Ser Ser Thr Ser Gly Ser Ser Ser Arg Asp Ser Ser Ser Ser 
     610                615                620
Thr Ser Ser Ser Ser Glu Ser Arg Ser Arg Ser Arg Gly Arg Gly His 
 625                630                635                640
Asn Arg Asp Arg Lys His Arg Arg Ser Val Asp Arg Lys Arg Arg Asp 
                 645                650                655
Thr Ser Gly Leu Glu Arg Ser Pro Lys Ser Ser Lys Gly Gly Ser Ser 
             660                665                670
Arg Asp Thr Lys Gly Ser Lys Asp Lys Asn Ser Arg Ser Asp Arg Lys 
         675                680                685
Arg Ser Ile Ser Glu Ser Ser Arg Ser Gly Lys Arg Ser Ser Arg Ser 
     690                695                700
Glu Arg Asp Arg Lys Ser Asp Arg Lys Asp Lys Arg Arg 
 705                710                715



<210> 7373
<211> 411
<212> DNA
<213> Rattus norvegicus
<308> AI639151
<400> 7373

ttaataatg  aagatgcat  tttatttct  caaaagcaa  gtatgatac  gaacataaa  60
gaacaatta  agatttacc  attaaaata  acagattct  actgaaaag  aatagggta  120
ttaaaaaag  tgacaaagg  tgttaatct  tttttatta  tatcatttt  acatatttt  180
gaacctcac  taattttga  aaataactc  tacaaaatt  tgcaaaaag  acaagaatg  240
ctggtaaac  aacagtctg  attttccaa  aagaatttt  acaacatgc  attcttaag  300
cagcatcct  tttacaagg  aatcctttt  ctcatcaaa  cttctgctg  aaagaatag  360
ctaagcaag  ctggcttct  ccattaacg  cttttgtct  tcctgtctg  t  411



<210> 7374
<211> 725
<212> PRT
<213> Rattus norvegicus
<308> NP_032917
<400> 7374

Met Ala Val Ala Val Arg Ala Leu Gln Glu Gln Leu Glu Lys Ala Lys 
  1               5                  10                  15
Glu Ser Leu Lys Asn Val Asp Glu Asn Ile Arg Lys Leu Thr Gly Arg 
             20                  25                  30
Asp Pro Asn Asp Val Arg Pro Ile Gln Gly Thr Leu Leu Ala Leu Ser 
         35                  40                  45
Gly Pro Gly Gly Gly Arg Gly Arg Gly Ser Leu Leu Leu Arg Arg Gly 
     50                  55                  60
Phe Ser Asp Ser Gly Gly Gly Pro Pro Ala Lys Gln Arg Asp Leu Glu 
 65                  70                  75                  80
Gly Ala Val Ser Arg Leu Gly Gly Glu Arg Arg Thr Arg Arg Glu Ser 
                 85                  90                  95
Arg Gln Glu Ser Asp Pro Glu Asp Asp Asp Val Lys Lys Pro Ala Leu 
             100                105                110
Gln Ser Ser Val Val Ala Thr Ser Lys Glu Arg Thr Arg Asp Leu Ile 
         115                120                125
Gln Asp Gln Asn Met Asp Glu Lys Gly Lys Gln Arg Asn Arg Arg Ile 
     130                135                140
Phe Gly Leu Leu Met Gly Thr Leu Gln Lys Phe Lys Gln Glu Ser Thr 
 145                150                155                160
Val Ala Thr Glu Arg Gln Lys Arg Arg Gln Glu Ile Glu Gln Lys Leu 
                 165                170                175
Glu Val Gln Ala Glu Glu Glu Arg Lys Gln Val Glu Asn Glu Arg Arg 
             180                185                190
Glu Leu Phe Glu Glu Arg Arg Ala Lys Gln Thr Glu Leu Arg Leu Leu 
         195                200                205
Glu Gln Lys Val Glu Leu Ala Gln Leu Gln Glu Glu Trp Asn Glu His 
     210                215                220
Asn Ala Lys Ile Ile Lys Tyr Ile Arg Thr Lys Thr Lys Pro His Leu 
 225                230                235                240
Phe Tyr Ile Pro Gly Arg Met Cys Pro Ala Thr Gln Lys Leu Ile Glu 
                 245                250                255
Glu Ser Gln Arg Lys Met Asn Ala Leu Phe Glu Gly Arg Arg Ile Glu 
             260                265                270
Phe Ala Glu Gln Ile Asn Lys Met Glu Ala Arg Pro Arg Arg Pro Ser 
         275                280                285
Met Lys Glu Lys Glu His Gln Val Val Arg Asn Glu Glu Gln Lys Ala 
     290                295                300
Glu Gln Glu Glu Gly Lys Val Ala Gln Arg Glu Glu Glu Leu Glu Glu 
 305                310                315                320
Thr Gly Asn Gln His Asn Asp Val Glu Val Glu Glu Ala Gly Glu Glu 
                 325                330                335
Glu Glu Lys Glu Ala Gly Ile Val His Ser Asp Ala Glu Lys Glu Gln 
             340                345                350
Glu Glu Glu Glu Gln Lys Gln Glu Met Glu Val Lys Ile Glu Glu Glu 
         355                360                365
Ala Glu Val Arg Glu Gly Glu Lys Gln Gln Asp Ser Gln Pro Glu Glu 
     370                375                380
Val Met Asp Val Leu Glu Met Val Glu Ser Val Lys His Val Ile Ala 
 385                390                395                400
Glu Gln Glu Val Met Glu Thr Asn Gln Val Glu Ser Ile Glu Pro Ser 
                 405                410                415
Glu Asn Glu Thr Ser Lys Glu Leu Glu Pro Glu Met Glu Phe Asp Val 
             420                425                430
Glu Pro Asp Lys Glu Cys Lys Ser Leu Ser Pro Gly Lys Glu Asn Ile 
         435                440                445
Asn Ser Gln Glu Val Glu Lys Glu Ser Glu Glu Lys Glu Glu Lys Glu 
     450                455                460
Glu Lys Glu Pro Glu Pro Gln Pro Glu Pro Val Ala Gln Pro Gln Pro 
 465                470                475                480
Pro Pro Gln Pro Leu Pro Gln Ser Gln Pro His Ser Gln Pro His Ser 
                 485                490                495
Gln Pro Gln Pro Val Leu Gln Ser Gln Pro Leu Cys Gln Pro Glu Thr 
             500                505                510
Leu Pro Leu Ala Val Leu Gln Pro Pro Pro Gln Val Ile Gln Glu Gln 
         515                520                525
Gly Asn Leu Leu Pro Glu Arg Lys Asp Phe Pro Leu Glu Ser Ile Lys 
     530                535                540
Leu Pro Glu Val Ser Val Glu Pro Val Leu Thr Val His Ser Glu Asn 
 545                550                555                560
Lys Ser Lys Asn Lys Thr Arg Ser Arg Ser Arg Gly Arg Ala Arg Asn 
                 565                570                575
Lys Thr Ser Lys Ser Arg Ser Arg Ser Ser Ser Ser Ser Ser Ser Ser 
             580                585                590
Ser Ser Ser Thr Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Gly Ser 
         595                600                605
Ser Ser Ser Arg Ser Ser Ser Ser Ser Ser Ser Ser Thr Ser Gly Ser 
     610                615                620
Ser Ser Arg Asp Ser Ser Ser Ser Thr Ser Ser Ser Ser Glu Ser Arg 
 625                630                635                640
Ser Arg Ser Arg Gly Arg Gly His Asn Arg Asp Arg Lys His Arg Arg 
                 645                650                655
Ser Met Asp Arg Lys Arg Arg Asp Thr Ser Gly Leu Glu Arg Ser His 
             660                665                670
Lys Ser Ser Lys Gly Gly Ser Ser Arg Asp Arg Lys Gly Ser Lys Asp 
         675                680                685
Lys Ser Ser Arg Pro Asp Arg Lys Arg Ser Ile Ser Glu Ser Ser Arg 
     690                695                700
Ser Gly Lys Arg Ser Ser Arg Ser Glu Arg Asp Arg Lys Ser Asp Arg 
 705                710                715                720
Lys Asp Lys Arg Arg 
                 725



<210> 7375
<211> 11787
<212> DNA
<213> Homo sapiens
<308> AF195139
<400> 7375

tctagatga  attcttgcc  tcatcacta  catcaagaa  aaggagtcc  agtccacca  60
acaagtcaa  aagtaagta  atggccaat  tatcaaagt  gacttctcc  accacaata  120
catgaggct  ttaaagtac  tttctggat  gaaaggaaa  ttatttaat  aggacctac  180
aactattga  cacagcatc  tacttatcc  tctccataa  gttaaattg  caaggctcc  240
aggaataga  cctatggaa  caaggacag  gagtgtggt  tgtgtgtgt  tgtgtgtgt  300
tgtgtgtgt  ttttgagac  gagttttgc  cttgttgcc  aggctggag  gcaatggca  360
tatctcagc  cactgcaac  ccgcctccc  ggttcaagt  attctcctg  ctcagcttc  420
cgagtaggt  ggattacag  catgcacca  caagcccag  tcattttgt  tttttagta  480
agacggggt  tctccatgt  ggtcaggct  atctcgaac  cgtgacctc  ggtgatccg  540
ctgcctcgg  ctcccaaag  gctgggatt  cagacttga  ccactgtgc  cagctgtgt  600
tgttttgtt  tgtttgaga  agagtctca  tgttgccca  gccagagtg  agtggcatg  660
tcttggctc  ctgcatgca  cctccacct  ccgggctca  gcaattctg  ctcagcctt  720
caagcagct  acactacag  cacttgcca  catgcagga  taattttgt  tttttagta  780
agacagggt  tcatcatgt  ggccaggct  gtcttgaac  cccaatctc  agtgatccg  840
ccaccaagg  ctcccaaaa  cctgggatt  ccgggccga  catacatgc  aacattctt  900
cacttgctg  acacgctct  ctattatca  actctcatg  ctcaggtac  gcctaaggt  960
gtacacaga  ctgtaataa  atcaatgag  ctaagtatg  tcacaatca  aattagata  1020
ttgtcaatc  tcatcccca  tattcatct  tacattttt  tctcctata  tacttcccg  1080
tttctaaca  gctatacta  ttatttatt  atttattta  ttttgagac  gagtctcac  1140
gctgcccag  ctagagtgc  gtggtgtga  gacagctca  tgcagtctc  aactcctgg  1200
ctcaaacaa  catcccgcc  cagcctctc  agtacaatt  ttaaaattt  tatttttag  1260
gacaggatc  ttgctatgt  gcccaggct  gtcttaact  ctgggctgt  gcgattctc  1320
cacctcagt  tcccaagta  ctgggatta  aggcacaat  cactggact  gctcagaga  1380
atctttatt  tacactgat  tacccaagt  cctagaata  cacctggca  atagtgggc  1440
ctcagtatt  gttgaacta  tgaatgatc  ttgctcctt  ggaagccta  aaaccccac  1500
gaagcagga  tcacaacta  cttgttcta  gctttattt  caaacccta  cttactgct  1560
atacacaat  gaagctcta  aagattgct  gattaaagt  gtagcttga  ttaattaat  1620
cactgggcc  actaattct  tgtacacgg  agatagatg  ctggctgag  ttatttaaa  1680
cattgtttc  gtgggaaag  gttttgttt  tttgtttgt  tgggacgga  tctcactct  1740
tcgcacagg  tagagtgca  tggtgcaat  tcggctcac  gcaacctcc  catcccggg  1800
tcccgagta  ctgggatta  aggcgtaca  caccactcc  agctaattt  tgtattttt  1860
gtaaaggcg  ggtttcccc  tgttggcca  gctggtctc  aactcctgg  ctcaagtga  1920
ccacctgcc  cagcctccc  aagtgctgg  attacgggc  tgngncact  tgcctggcc  1980
gtgaaaaaa  gttttctga  cttcaattt  tatatatat  tatagaata  aactagttc  2040
tacattggc  gtgcaggta  ggcagaacc  gaagcggga  aacacacac  gacaccact  2100
acaacaggg  cgctccctt  ggtctggtc  taaccagct  taggccagg  gaagaggct  2160
actcggcca  gactgcgtg  ctgtctcgc  attgctttc  tttctctag  atagatgct  2220
agcgtctaa  cagagactg  ttctcaact  gcgtgacca  aggacagtt  tattatctc  2280
agtctcaat  tccttatca  taataacag  cattttatc  acactttca  tttgtgaga  2340
ataaggcat  tagacggtt  cacagaggg  cgggaacaa  atcaacccc  aacaaacgt  2400
agccattat  actaatgac  tttactagt  ttcattttt  tcttccctc  tctcacttt  2460
acctaatca  gctgggcgt  gtggctcac  ctgtaatcc  agcaccctg  gaggtcgag  2520
caggcgaat  acctgaggt  aggagttcg  gaccagcct  cccaacatc  tggaatccg  2580
tctctaata  tacaaaaat  agccaggcg  gttgcgcgc  cctgtagtc  caggtactc  2640
ggaggctga  gcaggagaa  cgcttgaac  cgggaggag  aggttgcag  gagccgaga  2700
ggtgccact  cactccagc  tggacgaca  agcgagact  cgtgtgaaa  aaaaaaaat  2760
aacctaata  aggaaagca  gcgcccacc  cctctctga  catgcgcac  aacagaata  2820
ccgcgccct  tcctaatta  atcattaac  aaggtgagg  taaggaaga  aaggaggct  2880
ggctaagtc  cactctgat  tgatcacgt  aaaacggtg  aaggcacat  acatcatag  2940
ttaaaaggc  tagaaaact  cgcgctccc  ttgccagaa  tgcagactc  cgagcctaa  3000
tctccgaga  ctcagggat  gtgaaaccc  ccccgactc  gcgctagca  cgggatcca  3060
gcacccgca  ctaactggg  agggagatg  ctgcctggc  gacttttca  tggctcaga  3120
tcacaaagg  tgcaggttc  tcccccttc  ggtcgctga  tggttgagg  cggaagaca  3180
cgctcatcg  cattggctg  gcccggctg  cagtccttt  gcgcctcgg  ggcgcggca  3240
agcccggct  ggcctgtaa  gcagtctca  gcctgccgc  gggagaaga  ggcggtcgc  3300
gtgagaact  tgcaggaac  gctggaaaa  gccaaagag  gtcttaaga  cgtggatga  3360
aacattcgc  agctcaccg  gcgggatcc  aatgacgtg  ggtaagggc  taacgggaa  3420
tcggaactc  gagctcgga  aggcagccc  caggtcggg  tgaattggg  gcggggagg  3480
cggccagcc  taagaagac  ggaacctcg  ggcctgttc  cggggcggc  ggtaaaacc  3540
tgttgtcgc  gaggtggag  ggccccagg  cccctccgt  gagcgctgg  ctcaggtcc  3600
tgaggaagg  gagcgaggc  tgggtgcgc  ggcatgctt  cttggcctg  gagaagacc  3660
ggactgctg  ttcccgctc  cggccctgc  ggcccggaa  tgcagcaca  agccccttc  3720
cgctccggc  gacacccgg  ccgttgctg  ccccgagac  ctgccggac  caacaagcc  3780
ccttacccc  acttcctgt  cacgtgcag  ctcctcggg  atggcggga  ggggacctg  3840
tccaggctt  ttaatgtgt  ggggcatcg  ggtgaatat  atttctgtg  cacaggtcc  3900
ggagaaacg  ggaagttaa  tgaaatagt  cttcctgtc  tgtttcaga  atttagatt  3960
atttgaaac  atctttttg  aacttttgt  attttttct  cttatgatc  acatctctg  4020
aagtatttg  gtgcgactg  gtgtgtcta  atatgattt  gcactgatt  gtaaatctt  4080
tacaggccc  tccaagcca  attgctggc  ctttctggt  ctggtggag  tagaggacg  4140
ggtagttta  tactgaggt  agatttcct  tggacttta  tcatgctga  actactggt  4200
ctttactaa  tatgttggt  tgaacaaaa  ctgtgataa  atcaataac  cagtgtttg  4260
cgtctttgt  ttgtttaat  ttgtataga  tagatttct  tataaaagt  gttatcctg  4320
aaaactgga  gttgaagaa  atattaagt  taccaattt  gagtgaact  aattcttat  4380
aagtaacac  ataaaagca  tttggaatg  atgcccgtt  aaggctact  tagttggaa  4440
gatttttga  agtttaacc  tattctctt  tcaaatgga  ataccattt  tcttgtatt  4500
caagtgttt  atgttgaac  ttttaaatt  caggcgtgg  ttctcagat  gtggaggag  4560
acccccagc  aaacagaga  accttgaag  ggcagtcag  aggtaggtt  aaaaaaaga  4620
tcctgaagg  ttctttagt  tctgaggta  cacacaaat  taaatattt  ttaacaata  4680
ttctgtttc  gcaatatta  aattgagtg  tatgccact  cctgccccc  ccaagttct  4740
ttggtattt  actgaacag  tgactatca  ttccctcaa  acgcagttc  gcactcatg  4800
taagctaaa  tttatccaa  taaaggtca  gtgaagagt  aaattggaa  aattgtcaa  4860
tagtaccat  ttttctgac  tgtacttga  aaacttaac  agtttgaaa  acttagaaa  4920
tacaggaga  caaaattgg  ttgggcgtt  gttcacaca  tgtagtatc  tttctctgc  4980
ggaggaaag  ataaaatgg  atggagact  gatagaaca  agcttctgg  aacgagtcc  5040
agaagagag  gcatttgcc  ttggtgtgc  gttacataa  tacctcagt  gtcatttaa  5100
ttaattttt  gccaggcac  gtggctcat  cctgtaatc  cagcacttt  ggaagccaa  5160
accagcaga  cacttgagc  caggagttg  agaacagcc  agatacatg  tgaaatccc  5220
tccctacaa  aagtacaaa  aagttaccc  ggcatgctg  ctcacgcct  tagtcccag  5280
tgcttggga  gatgaggca  gaggatcac  tgagcctgg  aggtcgagg  tgcagtgaa  5340
cgtggtggc  ccactgcac  tcagcctgg  tggtatagt  aaaccctgt  tcaaaaaaa  5400
taatatttt  tatgacagg  tgggcgggg  gcgtcggac  agaagagaa  cacgccagg  5460
aagcgaccc  gaggatgat  atgttaaaa  ggtattgag  ttgaaagaa  ttaaatgaa  5520
gtagtacct  cactttact  catttaaaa  cacaccact  atatgctag  taaattact  5580
agattttct  tttctgcag  cagcattgc  gtcttcagt  gtagctacc  ccaaagagc  5640
cacacgtag  gaccttatc  aggatcaaa  tatggatga  aagggaaag  aaaggtatt  5700
ccctggggg  aaaaaactc  agtgaaata  tgcagttat  aggaaatca  gggattgtt  5760
aagcatcct  tagtatttc  tagaaaatc  tgggtttaa  tgaaatgga  cctgttgac  5820
gtaaatttt  ttattctgt  ctttaggaa  cggcgaata  ttggcttgt  gatgggtac  5880
cttcaaaaa  ttaaacaag  atccactgt  gctactgaa  gggtattta  ccaagtttt  5940
ttttgcatc  tatatttaa  ttatcaaag  agtagatta  tgttttttt  aaaaaatcc  6000
taaagctct  ttaagacct  actgtaaac  tgaaacaaa  ccaagtaaa  acttggttt  6060
acttcttat  gaacagctt  acttaaaca  gtgttggat  taacagttg  tgatatcat  6120
gctaatagt  tgaaattta  atatgtgaa  aaaaaaagc  tcaagtctc  atttcctta  6180
agacaaatt  cagtcagta  caagtgcta  gttctagtt  gttggtatc  tgaattgaa  6240
atgtgaagc  gccaggtgc  gtgctcatg  ctgtaatcc  agcactttg  gaggctgag  6300
caggtggat  acctgaggt  agaagtttt  cgagaccag  ctggccaac  tggtgaaac  6360
ctgtcttta  taaaaatac  aaattagcc  cctgtggtg  atgcgcctg  aatccccag  6420
tatttggga  gcggaggca  gagaatcac  tgaaccctg  aggtgaggt  gcaatgagc  6480
aagatcaca  tattgtacc  cagcctggg  aacaggcgc  aaactccat  tcaaaaaaa  6540
aaaaaatgt  aaggatatg  agatacctt  tttttttct  tttcttttt  tttgtagag  6600
tggggtttt  tcatgttgc  caggctggt  tgagctcaa  gcaatccac  cacctcagc  6660
tcccagagt  ctgggatga  aggtgtgag  cactgtgtt  ggaatgcag  tacctttac  6720
tagtgaaaa  aaaaaaaaa  aaaattttt  tttgagatg  agtttggct  ttcttgctc  6780
ggctggagt  tagtggcgt  atctcagct  actgcaacc  ccgcctctg  ggttcaagt  6840
atttctcct  cttcggcct  ccaagtagc  gggattata  gtgcgtgca  ccacgcctg  6900
taatttttt  gtgttttta  tagagatgg  ggtgttggc  tctgacttc  gatgatcta  6960
ctgcctcta  tgtttcacg  aattagtat  tgtaataac  ttttatcat  attgaactg  7020
aatcatata  accttttgt  gtaactatt  caacacgta  gtattaaag  aggctactt  7080
acttttagc  aaagcggcg  caggaaatt  aacaaaaac  tgaagttca  gcagaagaa  7140
agagaaagc  ggttgaaaa  gaaaggaga  aactgtttg  agagaggcg  gctaaacag  7200
cagaactgc  gcttttgga  cagaaagtt  agcttgcgc  gctggtgag  ggtaatttg  7260
aattctaag  ttggtaatc  tttgtgttt  caaaagcac  gacccttta  cttttcttt  7320
gcaagaaga  tggaatgaa  ataatgcca  aataattaa  tatataaga  ctaagacaa  7380
gccccattt  ttttatatt  ctggaagaa  gtgtccagc  acccaaaaa  taatagaag  7440
gtcacagag  aaaatgaac  gtaagtatg  gaagaggtc  attgaattg  tcatagtgg  7500
taaggtaat  tgttcatat  cacacgttt  ttttctaaa  taattatga  tcagtgatt  7560
gtttgctgt  tttggtttt  ttttttaaa  aagataata  gatattcta  gccgggcgt  7620
gtggctcac  cctgtaatc  cagcacttt  ggaggctga  gcaggcaga  catgaggtc  7680
ggagatcga  accatcccg  ctaacatgg  gaacccgtc  ctagtctct  ctaaataca  7740
aaaaaatta  ctgggcatg  tggtgggca  ctgtaattc  agctacttg  caggctgag  7800
caggagaat  acttgaacc  gggaggcag  agttgcagt  agccgagat  acgccactg  7860
actccagcc  gggcaacag  gctagactc  atctcaaaa  aaaaaaaaa  atacattct  7920
agatgctgg  gagtttgta  tataggaat  tttgtatca  gatggagtt  aatgtgaaa  7980
ttatagaca  tgcttatgc  tctgtattc  ttaagcatt  gtgtaaaat  acttttttt  8040
gcatgctat  attgttctg  taaaatgct  ataagacaa  tgtgaaaac  aactcagtt  8100
ctagatgga  aacacatgg  aggatagac  ctgctaaga  gatgattta  ctctttggg  8160
ctcagaaaa  ttaatatat  tgattttat  ccaaaactg  ttctgtttt  cagaagttt  8220
atttttcat  agacataaa  attgatctg  tttcttcat  agttagaaa  tgtgcagtt  8280
tgtctgcca  aatttctag  atgtagatt  cccatggat  tttgctttt  taattttat  8340
tcagtttgt  gttacttaa  tgccataat  ttttgtcat  actttacaa  aacaaattc  8400
gatgaagct  aatgacaat  tgtgaccag  tataaaatt  tggctttga  ttttcttaa  8460
cggtaaatt  tacacatgt  aatttttat  ctttagctt  atttgaagg  agacgcatc  8520
aatttgcag  acaaataaa  aaaatggag  ctaggccta  aagacaatc  atgaaggaa  8580
aagagcatc  ggtggtgcg  aatgaagaa  agaaggcgg  acaagaaga  ggtaaggtg  8640
ctcagcgag  ggaagagtt  gaggagaca  gtaatcagc  caatgatgt  gaaatagag  8700
aagcaggag  ggaagagga  aaggaaata  cgattgttc  tagtgatgc  gagaaagaa  8760
aggaggagg  agaacaaaa  caggaaatg  aggttaaga  ggaggagga  actgaggta  8820
gggaaagtg  gaagcagca  gatagtcag  ctgaagaag  tatggatgt  ctagagatg  8880
ttgagaatg  caaacatgt  attgctgag  aggaggtaa  ggaaactaa  cgagttgaa  8940
gtgtagaac  ttcagaaaa  gaagctagc  aagaattgg  accagaaat  gaatttgaa  9000
ttgagccag  taaagaatg  aaatccctt  ctcctggga  agagaatgt  agtgcttta  9060
acatggaaa  ggagtctga  gaaaaagaa  aaaaagaat  tgagcccca  cctgagcct  9120
tggctcaac  tcagcctca  tctcagccc  agcttcagc  tcaatccca  tcccaacca  9180
tactccagt  ccagcctcc  tctcagcct  aggatttgt  attagctgt  ttacagcca  9240
caccccaag  tactcagga  caagggcat  tactacctg  gaggaagga  tttcctgta  9300
agtctgtaa  actcactga  gtaccagta  agccagtct  gacagtaca  ccagagagc  9360
agagcaaaa  caaaactag  agcagaagt  gaggtcgag  tagaaataa  acaagcaag  9420
gtagaagtc  aagcagtag  agtagcagt  ctagtagca  ttcaaccag  agcagcagt  9480
gaagtagtt  cagcagtgg  agtagtagc  gtcgcagta  ttccagtag  agctccagt  9540
caagtggca  cagcagcag  gatagtagc  gtagcacta  tagtagtag  gagagtaga  9600
gtcggagta  gggccgggg  cataataga  atagaaagc  cagaaggag  gtggatcgg  9660
agagaaggg  tacttcagg  ctagaaaga  gtcccaaat  ttcaaaagg  ggtagtagt  9720
gagatacaa  aggatcaaa  gataagaat  cccggtccg  cagaaagag  tctatatca  9780
agagtagtc  atcaggcaa  agatcttca  gaagtgaaa  agaccgaaa  tcagacagg  9840
aagacaaaa  gcgttaatg  aagaagcca  gctttctta  ccattcttt  cagcagaag  9900
tttcttgat  aaaaaggat  acctttcct  gtaaagagg  tgctgcctt  agaattgca  9960
gttgtaaaa  atctttttg  aagatacag  ctgtttgtt  accagacat  cttgtactt  10020
ttgcataat  ttgtaagag  tatttatca  aattatgtg  ggttccaaa  tatgtaaaa  10080
tgataataa  aaaaaaaga  taacatccc  tgtcatctt  tttaaatat  ctatactct  10140
cagtaagaa  ctgtatatt  taataggca  atctttaag  ctgttccct  caattctgt  10200
tcatacatt  cttttgtag  aataaatgt  tgtttattt  attattttt  ggatgtcct  10260
gttgacact  gtataataa  tatcctctt  atcattttc  gcttttaac  ctagatact  10320
cacgtgatt  gaatgtttt  gaaggtttc  tcgttttta  ttgccttgg  cagttttta  10380
ttgtcagag  cagagcttt  cagctttga  ggggaacag  tctctttaa  atcatttgc  10440
attttctat  ctcccttgt  attttaatc  aagcatttt  ccccgtttc  catatttta  10500
ccatatgtt  ggtagataa  taaacagta  gatctggtt  gcattttct  cctgatgat  10560
ggagcgtca  tcttttgtc  tcatggtta  ttgtgtgat  taacataca  ctgttaaag  10620
aaatcactt  tttctaggg  agggaggta  aaaagtatc  ttcaaactt  gtttttgag  10680
ttgtgtctt  tcttaactt  gtgttggct  taacttaaa  atgctgata  gtgttttca  10740
gaattttgt  taaggaagt  ttgtatgga  gtccacaaa  tgaaggaag  tcatctagg  10800
tttaatatg  aagcaagat  acacacaag  gtaccaagt  attattaac  ttgttgttt  10860
acaaatttg  atgaacttg  agtatctgt  ggccattac  atacatgtg  aaataaatg  10920
ggcttagac  tgtgtgact  cttaagact  gtacttgta  taactttct  atgctttat  10980
caagagagc  cttaaattg  atccttcct  gagtttaac  ctgtagctt  agccttgac  11040
ttgaatatt  attttgcct  cccttgaca  gtaaatggt  acagtgaaa  tgtgaagaa  11100
tatttccag  tagtttttg  gtgtatata  ctcacttgt  taagtggat  tgttaaaag  11160
tctcttttt  aaaatcctt  tattggagt  attattaaa  cagtaaatg  atagagctt  11220
gcacagcaa  ctgtatcca  gagccagtt  caccactag  accttcatc  gtggcttat  11280
cagcaaaat  tttcatttc  tgtgtgccc  ggcaggaaa  aggttggta  atagtgaat  11340
aaagggatg  tcataaaat  taacctggt  aaaaagcac  ttatttgat  acagtttgt  11400
tgcactaaa  tcctttata  aaattaagt  ttgtctact  atttgtacc  ggaaaatct  11460
aacaatatt  atgttgctt  cagaaaagg  tagtattgg  ttgaagctc  acgatagga  11520
gggtagtaa  gggggtata  tgaatgctt  aggggaaag  aattttcag  aatttcagt  11580
aagcgctac  gatcatagt  tgtgaaagg  atttttctt  tatggaatg  ttgatgaat  11640
tgcatgtca  ccttgtgca  gggccattt  aatcttttt  ttttttttt  ttttctcgg  11700
gacagggtc  tagtctgtc  cccaggctg  agtgcagtg  cacaaacaa  ctgactgca  11760
cctcgacct  ctgggttca  gggatcc  11787



<210> 7376
<211> 717
<212> PRT
<213> Homo sapiens
<308> AAG33941
<400> 7376

Met Ala Val Ala Val Arg Thr Leu Gln Glu Gln Leu Glu Lys Ala Lys 
  1               5                  10                  15
Glu Ser Leu Lys Asn Val Asp Glu Asn Ile Arg Lys Leu Thr Gly Arg 
             20                  25                  30
Asp Pro Asn Asp Val Arg Pro Ile Gln Ala Arg Leu Leu Ala Leu Ser 
         35                  40                  45
Gly Pro Gly Gly Gly Arg Gly Arg Gly Ser Leu Leu Leu Arg Arg Gly 
     50                  55                  60
Phe Ser Asp Ser Gly Gly Gly Pro Pro Ala Lys Gln Arg Asp Leu Glu 
 65                  70                  75                  80
Gly Ala Val Ser Arg Leu Gly Gly Glu Arg Arg Thr Arg Arg Glu Ser 
                 85                  90                  95
Arg Gln Glu Ser Asp Pro Glu Asp Asp Asp Val Lys Lys Pro Ala Leu 
             100                105                110
Gln Ser Ser Val Val Ala Thr Ser Lys Glu Arg Thr Arg Arg Asp Leu 
         115                120                125
Ile Gln Asp Gln Asn Met Asp Glu Lys Gly Lys Gln Arg Asn Arg Arg 
     130                135                140
Ile Phe Gly Leu Leu Met Gly Thr Leu Gln Lys Phe Lys Gln Glu Ser 
 145                150                155                160
Thr Val Ala Thr Glu Arg Gln Lys Arg Arg Gln Glu Ile Glu Gln Lys 
                 165                170                175
Leu Glu Val Gln Ala Glu Glu Glu Arg Lys Gln Val Glu Asn Glu Arg 
             180                185                190
Arg Glu Leu Phe Glu Glu Arg Arg Ala Lys Gln Thr Glu Leu Arg Leu 
         195                200                205
Leu Glu Gln Lys Val Glu Leu Ala Gln Leu Gln Glu Glu Trp Asn Glu 
     210                215                220
His Asn Ala Lys Ile Ile Lys Tyr Ile Arg Thr Lys Thr Lys Pro His 
 225                230                235                240
Leu Phe Tyr Ile Pro Gly Arg Met Cys Pro Ala Thr Gln Lys Leu Ile 
                 245                250                255
Glu Glu Ser Gln Arg Lys Met Asn Ala Leu Phe Glu Gly Arg Arg Ile 
             260                265                270
Glu Phe Ala Glu Gln Ile Asn Lys Met Glu Ala Arg Pro Arg Arg Gln 
         275                280                285
Ser Met Lys Glu Lys Glu His Gln Val Val Arg Asn Glu Glu Gln Lys 
     290                295                300
Ala Glu Gln Glu Glu Gly Lys Val Ala Gln Arg Glu Glu Glu Leu Glu 
 305                310                315                320
Glu Thr Gly Asn Gln His Asn Asp Val Glu Ile Glu Glu Ala Gly Glu 
                 325                330                335
Glu Glu Glu Lys Glu Ile Ala Ile Val His Ser Asp Ala Glu Lys Glu 
             340                345                350
Gln Glu Glu Glu Glu Gln Lys Gln Glu Met Glu Val Lys Met Glu Glu 
         355                360                365
Glu Thr Glu Val Arg Glu Ser Glu Lys Gln Gln Asp Ser Gln Pro Glu 
     370                375                380
Glu Val Met Asp Val Leu Glu Met Val Glu Asn Val Lys His Val Ile 
 385                390                395                400
Ala Glu Glu Glu Val Met Glu Thr Asn Arg Val Glu Ser Val Glu Pro 
                 405                410                415
Ser Glu Asn Glu Ala Ser Lys Glu Leu Glu Pro Glu Met Glu Phe Glu 
             420                425                430
Ile Glu Pro Asp Lys Glu Cys Lys Ser Leu Ser Pro Gly Lys Glu Asn 
         435                440                445
Val Ser Ala Leu Asp Met Glu Lys Glu Ser Glu Glu Lys Glu Glu Lys 
     450                455                460
Glu Ser Glu Pro Gln Pro Glu Pro Val Ala Gln Pro Gln Pro Gln Ser 
 465                470                475                480
Gln Pro Gln Leu Gln Leu Gln Ser Gln Ser Gln Pro Val Leu Gln Ser 
                 485                490                495
Gln Pro Pro Ser Gln Pro Glu Asp Leu Ser Leu Ala Val Leu Gln Pro 
             500                505                510
Thr Pro Gln Val Thr Gln Glu Gln Gly His Leu Leu Pro Glu Arg Lys 
         515                520                525
Asp Phe Pro Val Glu Ser Val Lys Leu Thr Glu Val Pro Val Glu Pro 
     530                535                540
Val Leu Thr Val His Pro Glu Ser Lys Ser Lys Thr Lys Thr Arg Ser 
 545                550                555                560
Arg Ser Arg Gly Arg Ala Arg Asn Lys Thr Ser Lys Ser Arg Ser Arg 
                 565                570                575
Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Ser Ser Ser Ser 
             580                585                590
Gly Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Arg Ser Ser Ser Ser 
         595                600                605
Ser Ser Ser Ser Thr Ser Gly Ser Ser Ser Arg Asp Ser Ser Ser Ser 
     610                615                620
Thr Ser Ser Ser Ser Glu Ser Arg Ser Arg Ser Arg Gly Arg Gly His 
 625                630                635                640
Asn Arg Asp Arg Lys His Arg Arg Ser Val Asp Arg Lys Arg Arg Asp 
                 645                650                655
Thr Ser Gly Leu Glu Arg Ser Pro Lys Ser Ser Lys Gly Gly Ser Ser 
             660                665                670
Arg Asp Thr Lys Gly Ser Lys Asp Lys Asn Ser Arg Ser Asp Arg Lys 
         675                680                685
Arg Ser Ile Ser Glu Ser Ser Arg Ser Gly Lys Arg Ser Ser Arg Ser 
     690                695                700
Glu Arg Asp Arg Lys Ser Asp Arg Lys Asp Lys Arg Arg 
 705                710                715



<210> 7377
<211> 366
<212> DNA
<213> Rattus norvegicus
<308> AI639153
<400> 7377

ttctttaat  gcaatttat  gcaaaaaag  acatctggg  aagattggg  gcaaagtaa  60
gcagaggac  tgggcagtg  ggtattaat  aagattagg  ttgagcttc  tatctggtg  120
ttagttgtt  aagttgaat  taaattgag  caagtagag  ggtgaatct  cctgagcca  180
agcaggaag  agggcacag  cttctaggc  ttgttgcag  gagcttcat  acgacagca  240
ataatttgc  ttcttgttc  atgagagaa  aggttcata  atgggcaca  gttctcaca  300
ccttgaacc  tgaactgga  ctttccacc  tcatagatc  tctttaaca  gcactgctg  360
gaattt  366



<210> 7378
<211> 261
<212> PRT
<213> Rattus norvegicus
<308> NP_031417
<400> 7378

Met Lys Glu Leu Ile Leu Leu Gly Leu Tyr Leu Leu Gly Ser Ala Gln 
  1               5                  10                  15
Gly Ala Pro Pro Gly Gln Pro Glu Glu Leu Leu Asp Ser Val Asp Gln 
             20                  25                  30
Gln Ala Ser Val Gln Gln Leu Ser Ser Glu Tyr Leu Ser Leu Ala Asn 
         35                  40                  45
Pro Ser Asp Ala Glu Ala Leu Tyr Glu Thr Pro Leu Asp Glu Lys Thr 
     50                  55                  60
Leu Ser Gly His Ser Ser Ser Glu Gln Glu Ser Ser Glu His Ala Val 
 65                  70                  75                  80
Ala Glu His Ser Ala Gly Glu His Ser Ser Gly Glu Gln Ser Ser Glu 
                 85                  90                  95
His Met Ser Gly Asp His Met Ser Gly Glu His Leu Ser Glu His Thr 
             100                105                110
Ser Glu Glu His Ser Ser Gly Glu His Thr Ser Thr Glu His Thr Ser 
         115                120                125
Gly Glu Gln Pro Ala Thr Glu Gln Ser Ser Ser Asp Gln Pro Ser Glu 
     130                135                140
Ala Ser Ser Gly Glu Val Ser Gly Asp Glu Ala Gly Glu Gln Val Ser 
 145                150                155                160
Ser Glu Thr Asn Asp Lys Glu Asn Asp Ala Met Ser Thr Pro Leu Pro 
                 165                170                175
Ser Thr Ser Ala Ala Ile Thr Leu Asn Cys His Thr Cys Ala Tyr Met 
             180                185                190
Asn Asp Asp Ala Lys Cys Leu Arg Gly Glu Gly Val Cys Thr Thr Gln 
         195                200                205
Asn Ser Gln Gln Cys Met Leu Lys Lys Ile Phe Glu Gly Gly Lys Leu 
     210                215                220
Gln Phe Met Val Gln Gly Cys Glu Asn Met Cys Pro Ser Met Asn Leu 
 225                230                235                240
Phe Ser His Gly Thr Arg Met Gln Ile Met Cys Cys Arg Asn Glu Pro 
                 245                250                255
Leu Cys Asn Lys Val 
             260



<210> 7379
<211> 1043
<212> DNA
<213> Homo sapiens
<308> M82967
<400> 7379

gctatgaag  agctgtggc  cacactggg  tcccctctt  tcctaaatc  agatgaaca  60
gtttctctt  ctaatgagt  tttatctgc  tggatctgc  agaggaaca  caagtcagc  120
taatgagct  tctggctcc  tagatcatc  aacttcagt  cagcaactt  caggtgagt  180
cttttcact  gaaaaccct  ctgatgctg  ggctttata  gagacttct  caggcctga  240
cactttaag  gagcatggt  ccagtgagc  tggttcaag  aagcacact  tggccgagc  300
cacttctgg  gaacatgct  agagtgagc  tgcttcagg  gagcccgct  cgactgaac  360
tgctgaagg  gagcatact  taggtgagc  gccttcagg  gaacagcct  caggtgaac  420
cctctccgg  gaacagcct  tgagtgagc  tgagtcagg  gaacagcct  cagatgaac  480
gccttcagg  gaacatggc  ccggtgaac  gccttctgg  gagcaggcc  cgggtgaac  540
gccttcagg  acaatatta  attgctaca  atgtgctta  atgaatgat  aaggaaaat  600
tcttcgtgg  gagggaacc  gcatcactc  gaattccca  cagtgcatg  taaagaaga  660
ctttgaagg  ggaaaactc  aattcatgg  tcaagggtg  gagaacatg  gcccatcta  720
gaacctctt  tcccatgga  cgaggatgc  aattatatg  tgtcgaaat  aatctttct  780
caataagat  tagaagcct  ggcccttgc  tgttttgac  caggcagta  aaagcctcc  840
tcactctat  tggctcatt  tatatttag  tccttcccc  gtcaacaac  gaccacatc  900
gcctctgcc  gagcattag  atgctcaaa  atcctatct  tcttcttct  ttcatgctt  960
tatccattc  tctctgtcc  gtcttccct  ctccaactc  ttctctcaa  attcctgat  1020
tttttttca  taaatttca  atg  1043



<210> 7380
<211> 265
<212> PRT
<213> Homo sapiens
<308> P26436
<400> 7380

Met Asn Arg Phe Leu Leu Leu Met Ser Leu Tyr Leu Leu Gly Ser Ala 
  1               5                  10                  15
Arg Gly Thr Ser Ser Gln Pro Asn Glu Leu Ser Gly Ser Ile Asp His 
             20                  25                  30
Gln Thr Ser Val Gln Gln Leu Pro Gly Glu Phe Phe Ser Leu Glu Asn 
         35                  40                  45
Pro Ser Asp Ala Glu Ala Leu Tyr Glu Thr Ser Ser Gly Leu Asn Thr 
     50                  55                  60
Leu Ser Glu His Gly Ser Ser Glu His Gly Ser Ser Lys His Thr Val 
 65                  70                  75                  80
Ala Glu His Thr Ser Gly Glu His Ala Glu Ser Glu His Ala Ser Gly 
                 85                  90                  95
Glu Pro Ala Ala Thr Glu His Ala Glu Gly Glu His Thr Val Gly Glu 
             100                105                110
Gln Pro Ser Gly Glu Gln Pro Ser Gly Glu His Leu Ser Gly Glu Gln 
         115                120                125
Pro Leu Ser Glu Leu Glu Ser Gly Glu Gln Pro Ser Asp Glu Gln Pro 
     130                135                140
Ser Gly Glu His Gly Ser Gly Glu Gln Pro Ser Gly Glu Gln Ala Ser 
 145                150                155                160
Gly Glu Gln Pro Ser Gly Glu His Ala Ser Gly Glu Gln Ala Ser Gly 
                 165                170                175
Ala Pro Ile Ser Ser Thr Ser Thr Gly Thr Ile Leu Asn Cys Tyr Thr 
             180                185                190
Cys Ala Tyr Met Asn Asp Gln Gly Lys Cys Leu Arg Gly Glu Gly Thr 
         195                200                205
Cys Ile Thr Gln Asn Ser Gln Gln Cys Met Leu Lys Lys Ile Phe Glu 
     210                215                220
Gly Gly Lys Leu Gln Phe Met Val Gln Gly Cys Glu Asn Met Cys Pro 
 225                230                235                240
Ser Met Asn Leu Phe Ser His Gly Thr Arg Met Gln Ile Ile Cys Cys 
                 245                250                255
Arg Asn Gln Ser Phe Cys Asn Lys Ile 
             260                265



<210> 7381
<211> 567
<212> DNA
<213> Rattus norvegicus
<308> AI639154
<400> 7381

ttaagatgt  aattgtgct  agggaagcc  gaagagtgg  gtttcttag  actgcagtg  60
caggagttg  gggcacacc  acatgggca  tgggaatca  gcttgggtc  tattctaaa  120
atatatgtg  ttataatct  tctctaagt  ccaagctct  gtgggaatg  agtagcatg  180
ttcctgccc  tgggacagg  ccctggtgt  agcctcccg  agttgctca  cccagtgtg  240
caagtatcc  gtgtctgtc  tctgtgggt  taaggcttg  ttgagtaat  atgtatatc  300
tttcacatc  cttcaggga  tgccccctc  ctgaatgtt  atgactcca  gataatctg  360
ggcagcctg  gtccaggag  caaaggcgt  gctaatgtc  cagtaaaat  gtaaacctg  420
gatcttcaa  acagccctt  aggctgtgg  aaagaactc  aaatacatg  gttcaaaaa  480
atttaattc  aggggttgg  gatttagct  agtggtaga  ctaggaagc  caaggccct  540
gggtcgggc  ccagctcaa  aaaaaaa  567



<210> 7382
<211> 548
<212> DNA
<213> Rattus norvegicus
<308> AI639157
<400> 7382

ttagtggta  tgactgtgt  ttaagtcct  cctccccag  caggtccat  tgtcacctg  60
gaagatgtg  gctgacact  gatccagtt  cttggctgt  agtgtctct  cagggcctt  120
accagaagg  cattcaggc  gcctaccat  gcccgggga  catcaacga  tcctgctgc  180
atcatggcg  tctcataga  ctgatccac  agcagctgg  ctagctccg  ctcacgctc  240
ctcagctgg  tgagtttct  tattagtgt  tgcctgggg  tgatctcca  tgtgggctg  300
agcaactga  cacgctcct  ctgggtctt  gccagctgc  gcatgcgca  gaaatgtcg  360
gcagccccc  tctctagca  ggtcaccat  gcagggtgg  tgtccaggc  gaaagtcac  420
ttcacattg  tgacacggg  ccccagtgc  tttctcatc  atgccatta  ctcttctgt  480
tctttctca  agaggcgct  accagctgg  gatgtgtcc  caaactttt  ctccttgta  540
tgatcaac  548



<210> 7383
<211> 210
<212> PRT
<213> Rattus norvegicus
<308> P41123
<400> 7383

Ala Pro Ser Arg Asn Gly Met Ile Leu Lys Pro His Phe His Lys Asp 
  1               5                  10                  15
Trp Gln Gln Arg Val Asp Thr Trp Phe Asn Gln Pro Ala Arg Lys Ile 
             20                  25                  30
Arg Arg Arg Lys Ala Arg Gln Ala Lys Ala Arg Arg Ile Ala Pro Arg 
         35                  40                  45
Pro Ala Ser Gly Pro Ile Arg Pro Ile Val Arg Cys Pro Thr Val Arg 
     50                  55                  60
Tyr His Thr Lys Val Arg Ala Gly Arg Gly Phe Ser Leu Glu Glu Leu 
 65                  70                  75                  80
Arg Val Ala Gly Ile His Lys Lys Met Ala Arg Thr Ile Gly Ile Ser 
                 85                  90                  95
Val Asp Pro Arg Arg Arg Asn Lys Ser Thr Glu Ser Leu Gln Ala Asn 
             100                105                110
Val Gln Arg Leu Lys Glu Tyr Arg Ser Lys Leu Ile Leu Phe Pro Arg 
         115                120                125
Lys Pro Ser Ala Pro Lys Lys Gly Asp Ser Ser Ala Glu Glu Leu Lys 
     130                135                140
Leu Ala Thr Gln Leu Thr Gly Pro Val Met Pro Ile Arg Asn Val Tyr 
 145                150                155                160
Lys Lys Glu Lys Ala Arg Ala Ile Thr Glu Glu Glu Lys Asn Phe Lys 
                 165                170                175
Ala Phe Ala Ser Leu Arg Met Ala Arg Ala Asn Ala Arg Leu Phe Gly 
             180                185                190
Ile Arg Ala Lys Arg Ala Lys Glu Ala Ala Glu Gln Asp Val Glu Lys 
         195                200                205
Lys Lys 
     210



<210> 7384
<211> 2383
<212> DNA
<213> Homo sapiens
<308> AK026501
<400> 7384

ctcgagcat  ttggctact  tttccgctc  gctgttttc  tgcgcagga  gtgagggag  60
ctgggtcct  gcctttggg  atcatccag  gccatcggc  tggcgcttc  gccaacgcg  120
gagtggatg  gccccttct  cttcgcaga  agcgttcgg  cgctgcccg  gctctaggc  180
cggccggac  gcccagtct  gagggttcg  ggcggaggc  cgggggggt  cgcgcgccc  240
gggtccggc  tctcactcg  tcccctctc  tccgcagcc  cagggccgt  ggcagccat  300
gcgcccagc  ggaatggca  ggtcttgaa  ccccacttc  acaaggact  gcagcggcg  360
gtggccacg  ggttcaacc  gccggcccg  aagatccgc  ggtgagccc  gcgctcggg  420
ctgcccctg  ggctcgtgc  cgcggctgc  ccttggctt  cgggtggcc  atgccaggg  480
ggggggcgc  gtctgcaac  gtcgcggag  gctggcctg  cggccttag  caagggtga  540
cgccgctgc  cttctctcc  ccagacgta  ggcccggca  gccaaggcg  gccggcatc  600
ccccgcgcc  cgcgtcggg  cccatccgg  ccatcgtgc  ctgccccac  gttcggtac  660
acacgaagg  gcgcgccgg  cgcggcttc  gcctggagg  gctcagggt  agtactggc  720
gcgctgcgg  gtcaggaag  ccccgaagt  ccctctgtt  gcctcagtc  cgtgatgac  780
ttctccgga  tcgctgtac  gccttgatg  aagcacatt  gaacccttt  ccatctgat  840
gctgaggct  ttcatccag  cctcggggc  ggagaaagc  cgggcctgt  tccatctct  900
tctggttct  gggcaggtg  ccggcattc  caagaaggt  gcccggacc  tcggcattt  960
tgtggatcc  aggaggcgg  acaagtcca  ggagtccct  caggccaac  tgcagcggc  1020
gaaggagta  cgctccaaa  tcatcctct  ccccaggaa  ccctcggcc  ccaagaagg  1080
agacagttc  gtgagtaca  ggctctctg  ccgtcctgg  gcgcgggga  agtgaggct  1140
ggctccttt  tcagtgaca  cggtccctg  gtcttgctg  ggtgagaag  accaaaaca  1200
tgtgggtga  gagctaacg  gactgttaa  gttcacctg  gcgtttccg  agagataac  1260
ttaatggac  tggcaaggc  gtgtgactt  gaggcagct  tttccattg  cgttgctct  1320
cctaaaatg  ttcgtattc  aaaatattt  tagaaagac  ttgtaggat  aggttgata  1380
agagtccat  gtatacgtt  ccgggtagt  aaattaggg  acagttttc  ctgccccgc  1440
cgtggttca  aggtagata  ctgtctcgt  cgtgttgcg  caactcagt  agatatagt  1500
acctaacta  taaggactg  tcttaacat  ggggccaca  agtgtgttg  agaaaaggc  1560
cagacactg  tcctgaaca  ggaatcccc  ggggaaagt  tggggccag  tgagggtgg  1620
gtccttgca  cagtgcggc  aaccccact  aactcttct  attcaccaa  aggctgaag  1680
actgaaact  gccacccag  tgaccggac  ggtcatgcc  gtccggaac  taagtgaac  1740
cttactcaa  tccaggctt  agacgagat  agtgggtga  cacgtgggt  tctgagatg  1800
gggtaatgg  ggtcaggct  aagaacgtt  atagtggca  ttgtgggtg  ggaggtttg  1860
ggaaaggaa  atttcttct  agtttttac  tcttgcaac  atgaagcca  acattggga  1920
gtatttttg  ttgttttgt  tttttttgt  gttgttgga  agagagttt  tctatgctg  1980
ttacattgg  tttgaattg  tgggtttac  ggcttgagc  gccatgtcc  gctcaggga  2040
ggtttttct  ttttttttt  aatcccagg  aaggtgatt  actcagggt  gcttttcag  2100
agtacttat  gcagcgaac  tgaccccca  tccccggga  gtcctccgg  ttctcctga  2160
gcttggttg  tcccttgcc  tttggtgca  gtgggttta  caacctgtc  ttctcttct  2220
ggtctataa  aaggagaaa  ctcgagtca  cactgagga  gagaagaat  tcaaagcct  2280
cgctagtct  cgtatggcc  gtgccaacg  ccggctctt  ggcatacgg  caaaaagag  2340
caaggaagc  gcagaacag  atgttgaaa  aaaaaaaaa  aaa  2383



<210> 7385
<211> 210
<212> PRT
<213> Homo sapiens
<308> P26373
<400> 7385

Ala Pro Ser Arg Asn Gly Met Val Leu Lys Pro His Phe His Lys Asp 
  1               5                  10                  15
Trp Gln Arg Arg Val Ala Thr Trp Phe Asn Gln Pro Ala Arg Lys Ile 
             20                  25                  30
Arg Arg Arg Lys Ala Arg Gln Ala Lys Ala Arg Arg Ile Ala Pro Arg 
         35                  40                  45
Pro Ala Ser Gly Pro Ile Arg Pro Ile Val Arg Cys Pro Thr Val Arg 
     50                  55                  60
Tyr His Thr Lys Val Arg Ala Gly Arg Gly Phe Ser Leu Glu Glu Leu 
 65                  70                  75                  80
Arg Val Ala Gly Ile His Lys Lys Val Ala Arg Thr Ile Gly Ile Ser 
                 85                  90                  95
Val Asp Pro Arg Arg Arg Asn Lys Ser Thr Glu Ser Leu Gln Ala Asn 
             100                105                110
Val Gln Arg Leu Lys Glu Tyr Arg Ser Lys Leu Ile Leu Phe Pro Arg 
         115                120                125
Lys Pro Ser Ala Pro Lys Lys Gly Asp Ser Ser Ala Glu Glu Leu Lys 
     130                135                140
Leu Ala Thr Gln Leu Thr Gly Pro Val Met Pro Val Arg Asn Val Tyr 
 145                150                155                160
Lys Lys Glu Lys Ala Arg Val Ile Thr Glu Glu Glu Lys Asn Phe Lys 
                 165                170                175
Ala Phe Ala Ser Leu Arg Met Ala Arg Ala Asn Ala Arg Leu Phe Gly 
             180                185                190
Ile Arg Ala Lys Arg Ala Lys Glu Ala Ala Glu Gln Asp Val Glu Lys 
         195                200                205
Lys Lys 
     210



<210> 7386
<211> 595
<212> DNA
<213> Rattus norvegicus
<308> AI639162
<400> 7386

ttgcacaaa  tattttcaa  tttatttaa  tgaaataat  ttctaatat  atgaaaaac  60
gtcatagaa  tgacacaac  tttattgga  tagaaattt  aagacaaag  tatagtatc  120
attttatcc  ccattaatt  aatgcaaaa  ctatgcatg  caaattgct  cacacatgt  180
ggcattata  aatgtactc  gtatacttc  ttattataa  taactgaaa  caatatctt  240
tttttcaaa  ccacataac  aaactgcaa  taccacact  tttttcctc  tcgtttcac  300
ttatttttt  taatatgga  ggaaaaaca  tttacctta  ccaagatta  ttttaaaac  360
tctgtgggc  caaaaacag  aacaaccac  gtcacaaaa  tactaattt  ctttcacct  420
aatgaaaag  aagatttta  agggctcag  ttaagagag  tgtgacgga  ttactaaca  480
tagaaaaac  ttgtaacgc  tggacaaaa  actcataag  caaaatggt  ttttttgca  540
atataagta  aagaaagat  tgatggtaa  cagtacaaa  ctttttcta  aacca  595



<210> 7387
<211> 456
<212> DNA
<213> Rattus norvegicus
<308> AI639165
<400> 7387

ttgaacagt  tcctacatg  gatgccgag  acatgtgta  ccatcatag  gtctctagg  60
atctgtatt  aatttgcgt  ggggtggag  cagggattg  agatctgaa  ctgccacag  120
tttgtggca  atggctctg  gtcagctat  acaagcagc  aggctcggc  tcctctgca  180
attttcttt  ctctctgat  aggtaaata  gggcacact  tggaaagtt  ttcagattc  240
gccttaggc  gcaagtttg  gacttagcc  catctgtca  aaatcttcc  tgggttctg  300
tgtgagcag  gacctgaat  taccatgta  ggctgccca  gaaaatgga  ccacttcac  360
cttataaag  tgttttctt  taatgtctg  tctctcaca  aaactcttg  gcctttttg  420
aagctgttc  agtgtggaa  acagatact  agctgg  456



<210> 7388
<211> 365
<212> DNA
<213> Rattus norvegicus
<308> AI639169
<400> 7388

ttgccttaa  tgttttatt  caattaaaa  ttcacaaac  cagatcaat  aatctcaat  60
aaaataact  atgtttaca  catatttat  gacaagctg  acaataaat  cataaatgc  120
ttcacagtc  gtgcttcag  catcctcct  ctcctcttc  tcgctgatc  catacttct  180
atgcttttt  ttggccttg  catcgtcct  tgctttcct  ttcccagaa  actcacctt  240
ctcgtcact  ttgagcttc  ttgctttga  cagcctctg  gctttgtct  cttccgagc  300
ctcgtcgct  tctgaggag  agattctgg  ccgttcctc  cggatgcct  ctttgtagc  360
gtttt  365



<210> 7389
<211> 721
<212> DNA
<213> Homo sapiens
<308> BM015900
<400> 7389

ggacgcgtg  ggtagaaat  cccaaagta  acactgatt  aggaaacga  ttatatttg  60
taaactgcc  aactttctc  gtgtagagc  cagaccttt  gatcctcag  attatgaag  120
tgaatttga  gatgaagaa  tgctggatg  agaaggtag  accaggtta  aattaaagg  180
agaaaatac  ataagatgg  ggatacgcc  agatgaaga  ggaaatgaa  ttaaagaaa  240
caatgctcg  atagtcaag  ggtcagatg  aagcatgtc  ctgcattta  gcaatgaag  300
gtttgatgt  tacaaagcc  cactgcagg  cgaccacaa  catcttttt  taagacaag  360
tactggtct  cagggacaa  cagtcttta  aacgaaact  accttcaga  ctcactcta  420
ggacagtgc  acacataga  agatgactc  gtcacttgc  gataggtgt  caaagacac  480
gaagattag  atcttgcca  tggctggtc  tgatcctga  tgccaacgc  cagaaatga  540
taagaaaga  gaagaacgt  tgagggctt  catacgtag  gaatctcag  agcgccgaa  600
gagagagaa  cagcaccag  ggggggctg  gcgccagtt  cctggaacc  gatcgatac  660
atgaggagg  ggaaggcga  gagtccatc  gcttggctg  cattaaaac  aaaacaaaa  720
g  721



<210> 7390
<211> 365
<212> DNA
<213> Rattus norvegicus
<308> AI639169
<400> 7390

ttgccttaa  tgttttatt  caattaaaa  ttcacaaac  cagatcaat  aatctcaat  60
aaaataact  atgtttaca  catatttat  gacaagctg  acaataaat  cataaatgc  120
ttcacagtc  gtgcttcag  catcctcct  ctcctcttc  tcgctgatc  catacttct  180
atgcttttt  ttggccttg  catcgtcct  tgctttcct  ttcccagaa  actcacctt  240
ctcgtcact  ttgagcttc  ttgctttga  cagcctctg  gctttgtct  cttccgagc  300
ctcgtcgct  tctgaggag  agattctgg  ccgttcctc  cggatgcct  ctttgtagc  360
gtttt  365



<210> 7391
<211> 721
<212> DNA
<213> Homo sapiens
<308> BM015900
<400> 7391

ggacgcgtg  ggtagaaat  cccaaagta  acactgatt  aggaaacga  ttatatttg  60
taaactgcc  aactttctc  gtgtagagc  cagaccttt  gatcctcag  attatgaag  120
tgaatttga  gatgaagaa  tgctggatg  agaaggtag  accaggtta  aattaaagg  180
agaaaatac  ataagatgg  ggatacgcc  agatgaaga  ggaaatgaa  ttaaagaaa  240
caatgctcg  atagtcaag  ggtcagatg  aagcatgtc  ctgcattta  gcaatgaag  300
gtttgatgt  tacaaagcc  cactgcagg  cgaccacaa  catcttttt  taagacaag  360
tactggtct  cagggacaa  cagtcttta  aacgaaact  accttcaga  ctcactcta  420
ggacagtgc  acacataga  agatgactc  gtcacttgc  gataggtgt  caaagacac  480
gaagattag  atcttgcca  tggctggtc  tgatcctga  tgccaacgc  cagaaatga  540
taagaaaga  gaagaacgt  tgagggctt  catacgtag  gaatctcag  agcgccgaa  600
gagagagaa  cagcaccag  ggggggctg  gcgccagtt  cctggaacc  gatcgatac  660
atgaggagg  ggaaggcga  gagtccatc  gcttggctg  cattaaaac  aaaacaaaa  720
g  721



<210> 7392
<211> 463
<212> DNA
<213> Rattus norvegicus
<308> AI639172
<400> 7392

ttaatcagt  aaagcatct  tatttttgc  attatcatt  catacaaaa  caatagaaa  60
gcaaatatt  acaagttta  aattgaata  atgaacaga  ttatctgta  acatcattt  120
cagcaatat  acatggtaa  ttaactgat  attaaaaaa  aaaaaaaaa  aaagttctt  180
ctaaatccc  ctcttcctc  cttctgcat  aactcacag  gcatttact  aaatactta  240
ctcacacta  tgctatttc  agttccaaa  taaaactat  taacttaca  aaaagccca  300
taatataac  gcttaacat  tttgctcag  gctctgtat  agggaaagc  acattcaca  360
tgataaaag  ccagaaaat  agtttttac  aagtcactg  agctgcctg  ctgagaatt  420
ttcatcagt  acctaaagg  cagccaatt  taaattggt  cca  463



<210> 7393
<211> 275
<212> PRT
<213> Rattus norvegicus
<308> AAC53530
<400> 7393

Met Ala Cys Arg Pro Arg Ser Pro Pro Gly Tyr Gly Ser Arg Arg Asp 
  1               5                  10                  15
Gly Gly Ala Ser Pro Arg Ser Pro Ala Arg Trp Ser Leu Gly Arg Lys 
             20                  25                  30
Arg Arg Ala Asp Gly Arg Asp Arg Lys Pro Glu Asp Ser Glu Glu Gly 
         35                  40                  45
Glu Leu Gln Thr Ala Asp His Arg Pro Glu Ser Phe Thr Thr Pro Glu 
     50                  55                  60
Gly His Lys Pro Arg Ser Arg Cys Ser Asp Trp Ala Ser Ala Val Glu 
 65                  70                  75                  80
Glu Asp Glu Met Arg Thr Arg Val Asn Lys Glu Ile Ala Arg Tyr Lys 
                 85                  90                  95
Arg Lys Leu Leu Ile Asn Asp Phe Gly Arg Glu Arg Lys Ser Ser Ser 
             100                105                110
Gly Ser Ser Asp Ser Lys Glu Ser Met Ser Ser Val Pro Ala Asp Val 
         115                120                125
Glu Thr Asp Glu Ser Val Leu Met Arg Arg Gln Lys Gln Ile Asn Tyr 
     130                135                140
Gly Lys Asn Thr Ile Ala Tyr Asp Arg Tyr Ile Lys Glu Val Pro Arg 
 145                150                155                160
His Leu Arg Gln Pro Gly Ile His Pro Arg Thr Pro Asn Lys Phe Lys 
                 165                170                175
Lys Tyr Ser Arg Arg Ser Trp Asp Gln Gln Ile Lys Leu Trp Lys Val 
             180                185                190
Ala Leu His Phe Trp Asp Pro Pro Ala Glu Glu Gly Cys Asp Leu Gln 
         195                200                205
Glu Ile Gln Pro Val Asp Leu Gly Glu Met Glu Thr Glu Phe Thr Glu 
     210                215                220
Ser Ser Ser Glu Ser Gln Thr Ser Ser Gln Asp Asn Phe Asp Val Tyr 
 225                230                235                240
Ala Gly Thr Pro Thr Lys Val Arg His Val Asp Cys Gln Val Glu Asp 
                 245                250                255
Glu Phe Asp Leu Glu Ala Cys Leu Thr Glu Pro Leu Lys Asp Phe Ser 
             260                265                270
Ala Met Ser 
         275



<210> 7394
<211> 1716
<212> DNA
<213> Homo sapiens
<308> Z71188
<400> 7394

gcgggtttc  gcctcaggc  ctgccctgc  ctactctgc  ctctctgcc  gcgccgccg  60
cgcctcagc  tcggccctg  gctgcgcgc  cggcccgtg  tgccatggc  tgccgcccg  120
gaagcccgc  gaggcatca  agccgctgc  acggtgacg  cagcccgcc  tcccccgcg  180
gatggagcc  gggacggaa  cgcagagcc  acggcaggc  ctggaggcc  gaagacgcc  240
aggaggcag  gcaccgcgg  gccgagcgc  gacccgaga  ctttaccac  cctgaaggc  300
ctaaacccc  ttccagatg  tctgactgg  caagtgcag  tgaagaaga  gaaatgagg  360
ccagagtta  caaagaaat  gcaagatat  aaaggaaac  cctcatcaa  gactttgga  420
gagagagaa  atcatcatc  ggaagttct  attcaaagg  gtctatgtc  actgtgccg  480
ctgactttg  gacagatga  agtgtccta  tgaggagac  gaagcagat  aactatggg  540
agaacacaa  tgcctacga  cgttatatt  aagaagtcc  aagacacct  cgacaacct  600
gcattcatc  caagacccc  aataaattt  agaagtata  tcgacgttc  tgggaccag  660
aaatcaaac  ctggaaggt  gctctgcat  tttgggatc  tccagcgga  gaaggatgt  720
atttgcaag  aatacaccc  gtagacctt  aatctgcag  aagcagctc  gagccccag  780
ccagctctc  ggatgactt  gatgtgtac  ctggcacac  caccaaggt  agacacatg  840
acagtcaag  ggaggatga  tttgatttg  aagcttgtt  aactgaacc  ttgagagac  900
tctcagcca  gagctaact  ccccctggc  gccaggaag  gaaacagct  ctccccgac  960
aggtggaag  ctggccagg  accaagcat  tgtgtgcac  tgtacctgg  ggtttctct  1020
ttagcagtc  attagctca  gctgaatta  ttttgcctt  ctttcttaa  aaacattaa  1080
tttatgtat  gtgagtata  tttgcatgt  ttaaattgt  aatggagct  agtccaaga  1140
agtacttga  gctctcttc  agcgagctt  attgcgtaa  ccctgttgt  ctccagggt  1200
agctgacac  tctacataa  tggttttcc  caggcatct  cagttattg  ttgtcaggt  1260
gactgtttt  gatttaacc  tgtaatcca  gggaccaat  gagagtcag  tacttttat  1320
ggcatcaaa  tattctcag  cacctttaa  atctttatg  aaacttaat  tttggcctt  1380
tatcaatat  tcataacag  attctgaag  cagacattg  taaattgag  tattaaact  1440
atgagtttt  tgtaagtta  atggtctta  tttggtact  gtaaatagc  ctagttaga  1500
tctttagaa  actccaaga  ttagggcag  agagtggag  gatttagaa  gaacatttt  1560
aaacaatca  ttaatttac  atgtaaaat  gctgtaaat  ataatgtgt  cagattttc  1620
gttcaaata  tcaattgta  acttcttgt  aagactgtt  cgtttctat  gcttttgta  1680
gggatattg  aaaaataaa  aggaaagaa  cctctt  1716



<210> 7395
<211> 270
<212> PRT
<213> Homo sapiens
<308> Q14493
<400> 7395

Met Ala Cys Arg Pro Arg Ser Pro Pro Arg His Gln Ser Arg Cys Asp 
  1               5                  10                  15
Gly Asp Ala Ser Pro Pro Ser Pro Ala Arg Trp Ser Leu Gly Arg Lys 
             20                  25                  30
Arg Arg Ala Asp Gly Arg Arg Trp Arg Pro Glu Asp Ala Glu Glu Ala 
         35                  40                  45
Glu His Arg Gly Ala Glu Arg Arg Pro Glu Ser Phe Thr Thr Pro Glu 
     50                  55                  60
Gly Pro Lys Pro Arg Ser Arg Cys Ser Asp Trp Ala Ser Ala Val Glu 
 65                  70                  75                  80
Glu Asp Glu Met Arg Thr Arg Val Asn Lys Glu Met Ala Arg Tyr Lys 
                 85                  90                  95
Arg Lys Leu Leu Ile Asn Asp Phe Gly Arg Glu Arg Lys Ser Ser Ser 
             100                105                110
Gly Ser Ser Asp Ser Lys Glu Ser Met Ser Thr Val Pro Ala Asp Phe 
         115                120                125
Glu Thr Asp Glu Ser Val Leu Met Arg Arg Gln Lys Gln Ile Asn Tyr 
     130                135                140
Gly Lys Asn Thr Ile Ala Tyr Asp Arg Tyr Ile Lys Glu Val Pro Arg 
 145                150                155                160
His Leu Arg Gln Pro Gly Ile His Pro Lys Thr Pro Asn Lys Phe Lys 
                 165                170                175
Lys Tyr Ser Arg Arg Ser Trp Asp Gln Gln Ile Lys Leu Trp Lys Val 
             180                185                190
Ala Leu His Phe Trp Asp Pro Pro Ala Glu Glu Gly Cys Asp Leu Gln 
         195                200                205
Glu Ile His Pro Val Asp Leu Glu Ser Ala Glu Ser Ser Ser Glu Pro 
     210                215                220
Gln Thr Ser Ser Gln Asp Asp Phe Asp Val Tyr Ser Gly Thr Pro Thr 
 225                230                235                240
Lys Val Arg His Met Asp Ser Gln Val Glu Asp Glu Phe Asp Leu Glu 
                 245                250                255
Ala Cys Leu Thr Glu Pro Leu Arg Asp Phe Ser Ala Met Ser 
             260                265                270



<210> 7396
<211> 447
<212> DNA
<213> Rattus norvegicus
<308> AI639176
<400> 7396

ttattttta  ttttaaaaa  tcttctatt  tgcaatgat  aggtgattt  tgtctaagt  60
aacaagcaa  ccccaaatg  agagaaaga  aacaataaa  agtcaacca  aaaatcaat  120
aacaaagta  ttaaaataa  taatcatct  ccatgtata  tcttaaatg  aaataaacc  180
gatttacca  tgaagaaat  aaaacttgc  tgctggatt  aaaatcaag  tccaactat  240
tttagggta  ttgttttaa  ggagccact  ttcaccagc  aaagaaaat  aacatcaat  300
tgctaagca  atgaaaact  gaactggca  acgtatttt  gtcaatttt  aaaggtagt  360
ttgatgggt  gagccatct  agatgacag  tcactgtca  tgctttttt  cttttttat  420
tctttgaca  aagacctgc  aaaagca  447



<210> 7397
<211> 430
<212> DNA
<213> Rattus norvegicus
<308> AI639187
<400> 7397

ttaactcag  accaggggc  atttattag  caggtgtta  ttgccctgg  acatggctc  60
atcacaggc  cagaagaca  gctttacaa  agttccttc  ctggcagag  ctgttgtga  120
accaatacc  gagtttgga  gagctgagg  gttatttta  agctgtcag  gtccatcgc  180
gggtggtat  ggttcactg  cttttggac  gcatcttgt  ctcacccat  taccatgcc  240
aaccggttg  tctgcttca  cccttgccc  agaacagag  acttcagag  gctttcatt  300
gtgttttca  tagtgtggg  gtaagctta  ggtggaaag  ctggcccca  aatacaccc  360
ggcttgggg  agagtccta  tttatgtta  aaagctgtt  gctgtgctt  ctgtccctg  420
cacacatcct  430



<210> 7398
<211> 247
<212> PRT
<213> Rattus norvegicus
<308> AAH05702
<400> 7398

Met Pro Leu Leu Phe His Pro Ala Trp Pro Leu Leu Leu Gly Ala Thr 
  1               5                  10                  15
Leu Thr Phe Arg Ala Leu Arg Arg Val Leu Cys Arg Leu Pro Gln Pro 
             20                  25                  30
Ala His Val Gln Thr Asp Pro Leu Arg Thr Trp Arg Trp His Asn Leu 
         35                  40                  45
Leu Val Ser Phe Thr His Ser Ile Val Ser Gly Ile Trp Ala Leu Leu 
     50                  55                  60
Cys Leu Trp Gln Thr Pro Glu Met Leu Val Glu Ile Glu Thr Ala Trp 
 65                  70                  75                  80
Ser Ala Ser Gly Tyr Leu Leu Val Cys Phe Ser Ala Gly Tyr Phe Ile 
                 85                  90                  95
His Asp Thr Val Asp Ile Val Val Ser Lys Gln Thr Arg Ala Ser Trp 
             100                105                110
Glu Tyr Leu Val His His Val Met Ala Met Gly Ala Phe Phe Ser Gly 
         115                120                125
Ile Phe Trp Lys Arg Phe Val Gly Gly Gly Val Leu Thr Leu Leu Val 
     130                135                140
Glu Val Ser Asn Ile Phe Leu Thr Leu Arg Met Met Met Lys Ile Asn 
 145                150                155                160
Asn Ala Gln Asp Leu Leu Leu Tyr Lys Val Asn Lys Tyr Ile Asn Leu 
                 165                170                175
Val Met Tyr Phe Leu Phe Arg Leu Ala Pro Gln Ala Tyr Leu Thr Lys 
             180                185                190
Phe Phe Leu Gln Tyr Ala Gly Gln Arg Thr Leu Gly Thr Phe Leu Leu 
         195                200                205
Ala Ile Leu Leu Met Leu Asp Leu Met Ile Ile Ile Tyr Phe Ser Arg 
     210                215                220
Leu Leu Arg Ser Asp Phe Cys Pro Glu Arg Ala Pro Arg Arg Gln Gln 
 225                230                235                240
Lys Asp Lys Phe Leu Thr Glu 
                 245



<210> 7399
<211> 437
<212> DNA
<213> Rattus norvegicus
<308> AI639188
<400> 7399

ttcaatttt  agtatactt  attttctat  aaatgaaaa  caagaaaat  tcaagttaa  60
ttaaaaggc  ttacccttt  aagaaaaaa  tacaaactg  atggtgtga  acttgtata  120
caggtcata  tttacatta  acaatataa  caaaatcac  aatctacaa  tatttgaaa  180
tacacatga  ctacagatt  agtgggaaa  gggtttact  ttttggtgc  aataaacat  240
ttggaaaaa  atacagcat  catttttta  ctgtatgca  aagctctga  agtccattc  300
taatagccg  caccaccac  accaccacc  tcttttcct  gtccaaaat  accacctcc  360
taacccctt  gctggaatc  tccagatcc  ctatagccc  caccagatc  ccggtagtc  420
ccactagat  ctctgta  437



<210> 7400
<211> 1380
<212> PRT
<213> Rattus norvegicus
<308> AAC05725
<400> 7400

Met Gly Asp Ile Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys 
  1               5                  10                  15
Met Thr Pro Ala Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln 
             20                  25                  30
Lys Phe Met Cys Glu Val Arg Val Glu Gly Phe Asn Tyr Arg Gly Met 
         35                  40                  45
Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp 
     50                  55                  60
Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Val Lys Ser Glu Glu Val 
 65                  70                  75                  80
Pro Ala Val Gly Ile Val Pro Pro Pro Pro Ile Leu Ser Asp Thr Ser 
                 85                  90                  95
Asp Ser Thr Ala Ser Ala Ala Glu Gly Leu Pro Ala Pro Met Gly Gly 
             100                105                110
Pro Leu Pro Pro His Leu Ala Leu Lys Ala Glu Glu Asn Asn Ser Gly 
         115                120                125
Val Glu Ser Ser Gly Tyr Gly Ala Pro Gly Pro Thr Trp Asp Arg Gly 
     130                135                140
Ala Asn Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln 
 145                150                155                160
Ala Thr Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly 
                 165                170                175
Asn Trp Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn His Tyr Phe Gln 
             180                185                190
Lys Glu Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp 
         195                200                205
His Asn Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu 
     210                215                220
Gly Arg Arg Ile Phe Ala Arg Glu His Gly Cys Asn Lys Lys Leu Ala 
 225                230                235                240
Ala Gln Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly 
                 245                250                255
Cys Ile Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Arg 
             260                265                270
Val Glu Pro Tyr Lys Val Phe Leu Pro Pro Asp Leu Glu Leu Gln Leu 
         275                280                285
Gln Asn Val Val Gln Glu Leu Asp Leu Glu Ile Val Pro Pro Pro Val 
     290                295                300
Asp Pro Ser Met Pro Val Ile Leu Asn Ile Gly Lys Leu Ala His Phe 
 305                310                315                320
Glu Pro Ser Gln Arg Gln Asn Ala Val Gly Val Val Pro Trp Ser Pro 
                 325                330                335
Pro Gln Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly 
             340                345                350
Pro Leu Ala Tyr Ala Ser Thr Glu Gln Ile Ser Met Asp Leu Lys Asn 
         355                360                365
Glu Leu Thr Tyr Gln Met Glu Gln Asp His Asn Leu Gln Ser Val Leu 
     370                375                380
Gln Glu Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ala Glu Ile Leu 
 385                390                395                400
Glu Ala Ile Ser Ser Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly 
                 405                410                415
Cys Gly Lys Thr Thr Gln Val Pro Gln Tyr Ile Leu Asp Asp Phe Ile 
             420                425                430
Gln Asn Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg 
         435                440                445
Arg Ile Ser Ala Val Ala Val Ala Glu Arg Val Ala Tyr Glu Arg Gly 
     450                455                460
Glu Glu Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Ile 
 465                470                475                480
Leu Pro Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu 
                 485                490                495
Leu Arg Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val 
             500                505                510
Asp Glu Ile His Glu Arg Asp Ile Asn Thr Asp Phe Leu Leu Val Val 
         515                520                525
Leu Arg Asp Val Val Leu Ala Tyr Pro Glu Val Arg Ile Val Leu Met 
     530                535                540
Ser Ala Thr Ile Asp Thr Thr Met Phe Cys Glu Tyr Phe Phe Asn Cys 
 545                550                555                560
Pro Ile Ile Glu Val Tyr Gly Arg Thr Phe Pro Val Gln Glu Tyr Phe 
                 565                570                575
Leu Glu Asp Cys Ile Gln Met Thr Gln Phe Ile Pro Pro Pro Lys Asp 
             580                585                590
Lys Lys Lys Lys Asp Lys Glu Asp Asp Gly Gly Glu Asp Asp Asp Ala 
         595                600                605
Asn Cys Asn Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Lys Leu 
     610                615                620
Ser Met Ser Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu 
 625                630                635                640
Ala Leu Leu Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu 
                 645                650                655
Val Phe Leu Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu 
             660                665                670
Glu Asn Asn Ser His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu 
         675                680                685
His Ser Gln Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val 
     690                695                700
Pro Asp Gly Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr 
 705                710                715                720
Ser Ile Thr Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln 
                 725                730                735
Lys Val Lys Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ala Thr 
             740                745                750
Val Trp Ala Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly 
         755                760                765
Arg Val Arg Pro Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe 
     770                775                780
Asp Arg Leu Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu 
 785                790                795                800
His Glu Ile Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly 
                 805                810                815
Gln Phe Leu Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Ile Ile 
             820                825                830
Glu Ala Glu His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp 
         835                840                845
Glu Leu Thr Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro 
     850                855                860
Arg Phe Gly Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp 
 865                870                875                880
Ala Val Cys Thr Ile Ser Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile 
                 885                890                895
Ser Glu Gly Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn 
             900                905                910
Arg Phe Ser Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp 
         915                920                925
Asp Ala Arg Met Ser Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu Gln 
     930                935                940
Lys Arg Leu Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val 
 945                950                955                960
Gln Leu Lys Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu 
                 965                970                975
Leu Thr Gln Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val 
             980                985                990
Val Ile Ser Leu Leu Ala Phe Gly Val Tyr Pro Asn Val Cys Tyr His 
         995                1000                1005
Lys Glu Lys Arg Lys Ile Leu Thr Thr Glu Gly Arg Asn Ala Leu Ile 
     1010                1015                1020
His Lys Ser Ser Val Asn Cys Pro Phe Ser Ser Gln Asp Met Lys Tyr 
 1025                1030                1035                1040
Pro Ser Pro Phe Phe Val Phe Gly Glu Lys Ile Arg Thr Arg Ala Ile 
                 1045                1050                1055
Ser Ala Lys Gly Met Thr Leu Val Thr Pro Leu Gln Leu Leu Leu Phe 
             1060                1065                1070
Ala Ser Lys Lys Val Gln Ser Asp Gly Gln Ile Val Phe Ile Asp Asp 
         1075                1080                1085
Trp Ile Arg Leu Gln Ile Ser His Glu Ala Ala Ala Cys Ile Thr Ile 
     1090                1095                1100
Arg Ala Ala Met Glu Ala Leu Val Val Glu Val Ser Lys Gln Pro Asn 
 1105                1110                1115                1120
Ile Ile Ser Gln Leu Asp Pro Val Asn Glu His Met Leu Asn Thr Ile 
                 1125                1130                1135
Arg Gln Ile Ser Arg Pro Ser Ala Ala Gly Ile Asn Leu Met Ile Gly 
             1140                1145                1150
Ser Val Arg Tyr Gly Asp Gly Pro Arg Pro Pro Lys Met Ala Arg Tyr 
         1155                1160                1165
Asp Asn Gly Ser Gly Tyr Arg Arg Gly Tyr Gly Gly Gly Gly Tyr Gly 
     1170                1175                1180
Gly Gly Gly Tyr Gly Gly Gly Tyr Gly Ser Gly Gly Phe Gly Gly Gly 
 1185                1190                1195                1200
Phe Gly Ser Gly Gly Gly Phe Gly Gly Gly Phe Asn Ser Gly Gly Gly 
                 1205                1210                1215
Gly Phe Gly Ser Gly Gly Gly Gly Phe Gly Ser Gly Gly Gly Gly Phe 
             1220                1225                1230
Gly Gly Gly Gly Gly Gly Phe Ser Gly Gly Gly Gly Gly Gly Phe Gly 
         1235                1240                1245
Gly Gly Arg Gly Gly Gly Gly Gly Gly Phe Gly Gly Ser Gly Gly Phe 
     1250                1255                1260
Gly Asn Gly Gly Gly Gly Tyr Gly Val Gly Gly Gly Gly Tyr Gly Gly 
 1265                1270                1275                1280
Gly Gly Gly Gly Gly Tyr Gly Gly Gly Ser Gly Gly Tyr Gly Gly Gly 
                 1285                1290                1295
Gly Tyr Gly Gly Gly Glu Gly Tyr Ser Ile Ser Pro Asn Ser Tyr Arg 
             1300                1305                1310
Gly Asn Tyr Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Ser Gln Gly 
         1315                1320                1325
Gly Tyr Arg Asn Asn Phe Gly Gly Asp Tyr Arg Gly Ser Ser Gly Asp 
     1330                1335                1340
Tyr Arg Gly Ser Gly Gly Gly Tyr Arg Gly Ser Gly Gly Phe Gln Arg 
 1345                1350                1355                1360
Arg Gly Tyr Gly Gly Gly Tyr Phe Gly Gln Gly Arg Gly Gly Gly Gly 
                 1365                1370                1375
Gly Gly Gly Tyr 
             1380



<210> 7401
<211> 349
<212> DNA
<213> Rattus norvegicus
<308> AI639196
<400> 7401

ttcttgccc  aatctctag  catacaaaa  gctaaatgg  aaagaatac  cactcttgt  60
ctcatggaa  ttctgcttt  gtgggaaac  ttctgttca  atggaaagc  tcccaagaa  120
taacctcag  gttctgcct  agatctttt  ccccagatg  aagagtagc  ctaggctcc  180
tctatatca  gtgcctcag  tgtcctggg  cgggagtct  tcaggaaca  aacctactt  240
gaatgccat  atggcttta  ctatgtcaa  attcacagt  ctctacccg  aagatggta  300
gggcagaga  ggagacaga  aagattatc  atgcaatct  ctaacaatt  349



<210> 7402
<211> 493
<212> PRT
<213> Rattus norvegicus
<308> NP_076447
<400> 7402

Met Gln Trp Ile Arg Gly Gly Ser Gly Met Leu Ile Thr Gly Asp Ser 
  1               5                  10                  15
Ile Val Ser Ala Glu Ala Val Trp Asp His Val Thr Met Ala Asn Arg 
             20                  25                  30
Gly Val Ala Phe Lys Ala Gly Asp Val Ile Lys Val Leu Asp Ala Ser 
         35                  40                  45
Asn Lys Asp Trp Trp Trp Gly Gln Ile Asp Asp Glu Glu Gly Trp Phe 
     50                  55                  60
Pro Ala Ser Phe Val Arg Leu Trp Val Asn Gln Glu Asp Gly Val Glu 
 65                  70                  75                  80
Glu Gly Pro Ser Asp Val Gln Asn Gly His Leu Asp Pro Asn Ser Asp 
                 85                  90                  95
Cys Leu Cys Leu Gly Arg Pro Leu Gln Asn Arg Asp Gln Met Arg Ala 
             100                105                110
Asn Val Ile Asn Glu Ile Met Ser Thr Glu Arg His Tyr Ile Lys His 
         115                120                125
Leu Lys Asp Ile Cys Glu Gly Tyr Leu Lys Gln Cys Arg Lys Arg Arg 
     130                135                140
Asp Met Phe Ser Asp Glu Gln Leu Lys Val Ile Phe Gly Asn Ile Glu 
 145                150                155                160
Asp Ile Tyr Arg Phe Gln Met Gly Phe Val Arg Asp Leu Glu Lys Gln 
                 165                170                175
Tyr Asn Asn Asp Asp Pro His Leu Ser Glu Ile Gly Pro Cys Phe Leu 
             180                185                190
Glu His Gln Asp Gly Phe Trp Ile Tyr Ser Glu Tyr Cys Asn Asn His 
         195                200                205
Leu Asp Ala Cys Met Glu Leu Ser Lys Leu Met Lys Asp Ser Arg Tyr 
     210                215                220
Gln His Phe Phe Glu Ala Cys Arg Leu Leu Gln Gln Met Ile Asp Ile 
 225                230                235                240
Ala Ile Asp Gly Phe Leu Leu Thr Pro Val Gln Lys Ile Cys Lys Tyr 
                 245                250                255
Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr Thr Ala Gln Asp His Ser 
             260                265                270
Asp Tyr Arg Tyr Val Ala Ala Ala Leu Ala Val Met Arg Asn Val Thr 
         275                280                285
Gln Gln Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile Asp Lys Ile 
     290                295                300
Ala Gln Trp Gln Ala Ser Val Leu Asp Trp Glu Gly Asp Asp Ile Leu 
 305                310                315                320
Asp Arg Ser Ser Glu Leu Ile Tyr Thr Gly Glu Met Ala Trp Ile Tyr 
                 325                330                335
Gln Pro Tyr Gly Arg Asn Gln Gln Arg Val Phe Phe Leu Phe Asp His 
             340                345                350
Gln Met Val Leu Cys Lys Lys Asp Leu Ile Arg Arg Asp Ile Leu Tyr 
         355                360                365
Tyr Lys Gly Arg Ile Asp Met Asp Lys Tyr Glu Val Ile Asp Ile Glu 
     370                375                380
Asp Gly Arg Asp Asp Asp Phe Asn Val Ser Met Lys Asn Ala Phe Lys 
 385                390                395                400
Leu His Asn Lys Glu Thr Glu Glu Val His Leu Phe Phe Ala Lys Lys 
                 405                410                415
Leu Glu Glu Lys Ile Arg Trp Leu Arg Ala Phe Arg Glu Glu Arg Lys 
             420                425                430
Met Val Gln Glu Asp Glu Lys Ile Gly Phe Glu Ile Ser Glu Asn Gln 
         435                440                445
Lys Arg Gln Ala Ala Met Thr Val Arg Lys Ala Ser Lys Gln Lys Gly 
     450                455                460
Arg Val Gly Glu Glu Glu Asn Gln Ser Leu Glu Leu Lys Arg Ala Cys 
 465                470                475                480
Glu Val Leu Gln Arg Leu Trp Ser Pro Gly Lys Lys Ser 
                 485                490



<210> 7403
<211> 5413
<212> DNA
<213> Homo sapiens
<308> AB007884
<400> 7403

gaagaggga  agggccagc  aggcaggga  cgaacgagt  tctggcagc  gggagccca  60
cgaagagag  gagcaagct  aggaaaacg  gcgaagtaa  gggagtagg  gagactgag  120
ctgaccggt  gccaggcag  cggacggac  cacgcccgg  cagactgag  aggcgccgg  180
gaaccactc  caggttccc  ccgcctttc  ctttgaaag  taggatttt  cctttcccg  240
ggcgcccga  agagaatgc  ggactctgc  gacttcagc  caagctaag  tttctcagc  300
agggacaaa  gatcagccc  atcctgaga  ggggggaac  aagcacccc  tccccatcc  360
cctcccctc  cccgactaa  ctcgggcgc  aaacccagc  cttctctaa  caccctact  420
cctcctctc  tttctagca  ggtggctgt  tggacagtc  gacagaaca  agactgaca  480
ctcccaatc  gccggcccc  cacctggaa  actacagtg  tctgcattg  accatgacc  540
tggatgtgc  aactgtagt  gtttttgcc  tgattgtag  cctcctgct  gtcaatgtc  600
tactcatgt  tttcctggg  acgcgctga  tggagtcca  ccacctgag  tgtcgcgaa  660
tctcgcttt  atttcatcc  gagagccac  gagaaaaaa  aaaaatcac  gacagagac  720
gggaaagag  gagaaagaa  aagctttct  actcagggg  gaaaacgtt  tgagcttca  780
catggcctc  ctgtgatat  tatgacgtt  ctgatcact  gagattcca  cgttagtgc  840
gaggcagta  gggatcacg  caccatggc  aaccgggag  tggcattta  agctggcga  900
gtcatcaaa  tcttggatg  ttccaacaa  gattggtgg  ggggccaga  cgacgatga  960
gagggatgg  ttcctgcca  ctttgtgag  ctctgggtg  accaggagg  tgaggtgga  1020
gaggggccc  gcgatgtgc  gaacggaca  ctggacccc  attcagact  cctctgtct  1080
gggcggcca  tacagaacc  ggaccagat  cgggccaat  tcatcaatg  gataatgag  1140
actgagcgt  actacatca  gcacctcaa  gatatttgt  agggctatc  gaagcagtg  1200
cggaagaga  gggacatgt  cagtgacga  caactgaag  taatctttg  gaacattga  1260
gatatctac  gatttcaga  gggctttgt  agagacctg  agaaacagt  taacaatga  1320
gacccccac  tcagcgaga  aggaccctg  ttcctagag  accaagatg  attctggat  1380
tactctgag  attgtaaca  ccacctgga  gcttgcatg  agctctcca  actgatgaa  1440
gacagccgc  accagcact  ctttgaggc  tgtcgcctc  tgcagcaga  gattgacat  1500
gctatcgat  gtttccttt  gactccagt  cagaagatc  gcaagtatc  cttacagtt  1560
gctgagctc  taaagtata  tgcccaaga  cacagtgac  acaggtatg  ggcagctgc  1620
ttggctgtc  tgagaaatg  gactcagca  atcaacgaa  gcaagcgac  tttagagaa  1680
attgacaag  ttgctcagt  gcaggcttc  gtcctagac  gggagggcg  ggacatcct  1740
gacaggagc  cggagctga  ctacactgg  gagatggcc  ggatctacc  gccctacgg  1800
cgcaaccag  agcgggtct  cttcctgtt  gaccaccag  tggtcctct  caagaagga  1860
ctaatccgg  gagacatcc  gtactacaa  ggccgcatt  acatggata  atatgaggt  1920
gttgacatt  aggatggca  agatgatga  ttcaatgtc  gcatgaaga  tgcctttaa  1980
cttcacaac  aggagactg  ggagataca  ctgttcttt  ccaagaagc  ggaggaaaa  2040
atacgctgg  tcagggctt  cagagaaga  aggaaaatg  tacaggaag  tgaaaaaat  2100
ggctttgaa  tttctgaaa  ccagaagag  caggctgca  tgactgtga  aaaagtccc  2160
aagcaaaaa  gtgtcaact  tgcccgctc  gttcctcct  cctacccac  accgcagga  2220
ccgttaaac  acggccagt  cctggtccc  gacggcatc  ctcagtcgc  ggtctttga  2280
ttcaccgaa  ccaagcgca  ccagtcacc  ttctggcaa  acttcagca  gttaacccc  2340
ttcaaaaaa  gatacctac  gggaggcag  taattttaa  ataaagtaa  taaaattat  2400
tttatagat  gaccttttt  cggagaagc  ctgttgaaa  ttatacaca  acacacaca  2460
agagaccct  gagtacaca  acacacaca  acacacaga  acacacaca  acacacaca  2520
acacacaca  acagagaga  aaggaacaa  agtgttttc  gttgttttg  ggaagtgaa  2580
tatgtggtt  gtaggaaga  gtaccaatg  cttccaaac  tgtgattcc  tcttaaaag  2640
tttccattt  taccctgtc  cccttccct  tgctttcag  agttgacat  tctattcat  2700
gcttttctt  ttaagataa  ctctttact  ccctgtgag  gattcactg  cttgtcatt  2760
ttacgatag  tgtgtttgt  ttgtttttt  tctgatgat  ctgatgttg  tgaattttt  2820
attttattt  atgtggtag  gttgggagg  ttcagggtt  tttcccctc  tttactttc  2880
attgaggaa  ggaatgagc  cctttctcc  ctccttcag  caatcatta  caaatgttc  2940
ttcagccct  cagttgccc  aaataacct  ttttcagca  cctctgtcc  cagtcatgc  3000
agtctggac  tgctctgtt  tgccctgtg  caaaactgc  cagtattcc  attgctttt  3060
ctgtgtttt  ggtactgtg  agggatcaa  aaaccaaac  gaagcaagg  agtatcaga  3120
tatgatgat  ctggagtgg  cttctgttc  gggaacatt  tgcattcag  ctgtttctt  3180
tatcactgg  gtttcccat  ttgcagcac  tctgggtcg  tgcaatttt  catctagga  3240
ttagtttga  cgagttatt  tcttttttc  agtcacttt  gttataggt  tccccctag  3300
cctgtctct  ccttagccc  aaagatctg  actggaagc  gaggttgag  ttctgcctc  3360
caggagagg  atttacctg  cccctagta  cagataggt  tagggcagt  atctctaca  3420
caatcagtt  agtgtcctg  ttgtccctg  tcccattta  agatgtttg  gcagcattg  3480
tagaagtat  gaggggttc  agacagagc  cacctgatc  agatcatca  ctaccttca  3540
attattgac  tggacaggg  ccaagtctg  tagtaacct  ttacaagaa  gaacaggga  3600
gggaatgga  agagatagc  ttgatccac  gtattgtac  tgcattttc  accacccta  3660
aattgtgtg  gacttctcc  attgttaac  gattgcatg  acaatcttc  ctggcttct  3720
tctttccct  tctctttct  ctttctcct  ccatcctag  acaggagga  ttttggtat  3780
gatatagtt  aagctgttc  ggcactcaa  gaaggccgt  tttccaaca  cctctcatc  3840
caggacatt  ggggcaagt  agttagggg  ccaggggca  ttttccctc  gaataacgt  3900
tctgaggca  ggatgctac  ctcaggctc  cttttggcc  gctttttgc  tgggaaaat  3960
taacttctt  cacaaggag  caggcttcc  atggatgtt  gagtacctg  ttttcctcc  4020
cacatagcc  ttttcatgg  tagaccttg  acaacaaaa  gggtataag  gaataagga  4080
gaactctgc  gtgaagagc  agccactgt  gtgaggaat  tggagactg  gagtctgtc  4140
taaacccca  gggagaaga  ttcatcatg  caggacttc  gcttaccaa  cagcagcca  4200
agctgtgtg  aggcttcag  atagctagc  tgtttactg  tctatgcct  ctgatccag  4260
ccaggcatt  cccagcctg  gaatctttt  tttgtggga  tcaaattac  agctattta  4320
gtttatatt  catcacaac  aagtcagac  tgtattata  gtcaaggat  agcctgatc  4380
ggggagagg  ccggggctc  ggactggcc  ccactgttc  gcacatgac  taactacgt  4440
agcctcttt  gcaagggtc  tggtgccca  cacccaggc  aaaatatcc  gtctggcag  4500
gtgttttgg  agctatgca  gcctccctt  agtgtacct  tttttccaa  ttctcactc  4560
tccttacta  gcttggcct  gacatgctt  ttcgagggt  ggcagcaca  cgggagggg  4620
tgcttggac  agtttctgg  cctacattt  ttgactagg  cctctcatt  cctccctcc  4680
tggggcttc  gcccagggc  ccaggatca  ggatattac  tctcaaccc  cacttctcc  4740
ctactgaac  cactggcat  acctgatgc  actaatttg  gaacaacaa  aaatcattt  4800
cccattggt  ggagtattc  ctcagccta  agcatcaaa  cagaccagt  gccaacagc  4860
ccaagggga  cccaattaa  tacctgggt  cagtatcct  acctgttat  tcctgacag  4920
aatggtaac  ccagtaatt  tgtaatgtt  taatttccg  atggccctg  gctcccttt  4980
cctcaactc  gtgaggcca  gatttgctc  ccaaaaggc  ttgctagtg  gttcaatgg  5040
acctgctgt  gggagtcct  agacagaca  ctaattatt  tctcttttt  cccccctct  5100
tatgtgtat  tttctaatg  atctataag  acagcaaca  gagagttct  acaattcta  5160
tgtgaagcc  aatagtgat  ttttagtgc  ttggggatg  ggtgggctg  ggtggatgg  5220
tgggcaaca  tgactttga  tacccttgc  gctctgcat  tgccagttt  ttcttttgt  5280
tcttttatc  gactgactc  gtcaaacaa  tgtcaaagt  gtgtgttaa  aaatgttta  5340
caaaaaaaa  tgttgtaat  acacaaagc  ttatgaaaa  atttatgga  ttcaataaa  5400
gaagtaaaa  gac  5413



<210> 7404
<211> 516
<212> PRT
<213> Homo sapiens
<308> NP_056000
<400> 7404

Met Thr Leu Leu Ile Thr Gly Asp Ser Ile Val Ser Ala Glu Ala Val 
  1               5                  10                  15
Trp Asp His Val Thr Met Ala Asn Arg Glu Leu Ala Phe Lys Ala Gly 
             20                  25                  30
Asp Val Ile Lys Val Leu Asp Ala Ser Asn Lys Asp Trp Trp Trp Gly 
         35                  40                  45
Gln Ile Asp Asp Glu Glu Gly Trp Phe Pro Ala Ser Phe Val Arg Leu 
     50                  55                  60
Trp Val Asn Gln Glu Asp Glu Val Glu Glu Gly Pro Ser Asp Val Gln 
 65                  70                  75                  80
Asn Gly His Leu Asp Pro Asn Ser Asp Cys Leu Cys Leu Gly Arg Pro 
                 85                  90                  95
Leu Gln Asn Arg Asp Gln Met Arg Ala Asn Val Ile Asn Glu Ile Met 
             100                105                110
Ser Thr Glu Arg His Tyr Ile Lys His Leu Lys Asp Ile Cys Glu Gly 
         115                120                125
Tyr Leu Lys Gln Cys Arg Lys Arg Arg Asp Met Phe Ser Asp Glu Gln 
     130                135                140
Leu Lys Val Ile Phe Gly Asn Ile Glu Asp Ile Tyr Arg Phe Gln Met 
 145                150                155                160
Gly Phe Val Arg Asp Leu Glu Lys Gln Tyr Asn Asn Asp Asp Pro His 
                 165                170                175
Leu Ser Glu Ile Gly Pro Cys Phe Leu Glu His Gln Asp Gly Phe Trp 
             180                185                190
Ile Tyr Ser Glu Tyr Cys Asn Asn His Leu Asp Ala Cys Met Glu Leu 
         195                200                205
Ser Lys Leu Met Lys Asp Ser Arg Tyr Gln His Phe Phe Glu Ala Cys 
     210                215                220
Arg Leu Leu Gln Gln Met Ile Asp Ile Ala Ile Asp Gly Phe Leu Leu 
 225                230                235                240
Thr Pro Val Gln Lys Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu 
                 245                250                255
Leu Lys Tyr Thr Ala Gln Asp His Ser Asp Tyr Arg Tyr Val Ala Ala 
             260                265                270
Ala Leu Ala Val Met Arg Asn Val Thr Gln Gln Ile Asn Glu Arg Lys 
         275                280                285
Arg Arg Leu Glu Asn Ile Asp Lys Ile Ala Gln Trp Gln Ala Ser Val 
     290                295                300
Leu Asp Trp Glu Gly Glu Asp Ile Leu Asp Arg Ser Ser Glu Leu Ile 
 305                310                315                320
Tyr Thr Gly Glu Met Ala Trp Ile Tyr Gln Pro Tyr Gly Arg Asn Gln 
                 325                330                335
Gln Arg Val Phe Phe Leu Phe Asp His Gln Met Val Leu Cys Lys Lys 
             340                345                350
Asp Leu Ile Arg Arg Asp Ile Leu Tyr Tyr Lys Gly Arg Ile Asp Met 
         355                360                365
Asp Lys Tyr Glu Val Val Asp Ile Glu Asp Gly Arg Asp Asp Asp Phe 
     370                375                380
Asn Val Ser Met Lys Asn Ala Phe Lys Leu His Asn Lys Glu Thr Glu 
 385                390                395                400
Glu Ile His Leu Phe Phe Ala Lys Lys Leu Glu Glu Lys Ile Arg Trp 
                 405                410                415
Leu Arg Ala Phe Arg Glu Glu Arg Lys Met Val Gln Glu Asp Glu Lys 
             420                425                430
Ile Gly Phe Glu Ile Ser Glu Asn Gln Lys Arg Gln Ala Ala Met Thr 
         435                440                445
Val Arg Lys Val Pro Lys Gln Lys Gly Val Asn Ser Ala Arg Ser Val 
     450                455                460
Pro Pro Ser Tyr Pro Pro Pro Gln Asp Pro Leu Asn His Gly Gln Tyr 
 465                470                475                480
Leu Val Pro Asp Gly Ile Ala Gln Ser Gln Val Phe Glu Phe Thr Glu 
                 485                490                495
Pro Lys Arg Ser Gln Ser Pro Phe Trp Gln Asn Phe Ser Arg Leu Thr 
             500                505                510
Pro Phe Lys Lys 
         515



<210> 7405
<211> 432
<212> DNA
<213> Rattus norvegicus
<308> AI639209
<400> 7405

ttgtactta  aagaaaaaa  tcaaatagt  accatacac  tgaggaata  aatgttaca  60
aaaaagact  tcctcagtc  tatttgtga  aggaaaatg  aaacaattg  cctgtcaaa  120
gatgacaca  taaggtaaa  cattgtagc  tttttgtaa  gaagaattc  atctggtaa  180
aggtgagag  cttgacaac  atacatttg  gccttggtt  ttgagaagg  tttgctata  240
tctaggctg  acagacaac  caatcctgg  tcactggag  tatgaagtt  gtgcctctg  300
gtttttctg  tgctgagac  cacatatgc  ctacacaaa  ctttacttc  ataacatta  360
ttttaaagg  tagaacatg  acaacataa  tgctatgtt  cccaacatt  aaggaatat  420
taaaaatta  tt  432



<210> 7406
<211> 373
<212> DNA
<213> Rattus norvegicus
<308> AI639215
<400> 7406

ttgcagcaa  actaataca  taaggttca  aaaggaaat  gtgtaaata  ctcagatcc  60
aggccagcc  tgcttgtgt  cagaacgga  tctccctcc  ggaccactg  cagcaggct  120
tccccgggc  aaaggactc  gcaaggaaa  caacgctag  catggtaga  cgcccttgc  180
atgtcagca  gaggaggct  aggcaggag  atctcgagt  aagaaacag  cagtaccaa  240
tggcaaagt  cttctcaga  ggaagcaag  aacttaagt  aaacatgga  ctgctggcc  300
gagcccagc  catgtaggg  cactcagtg  acttgagga  aaaagtacc  atgtgccac  360
cctgctgtg  tgg  373



<210> 7407
<211> 508
<212> DNA
<213> Rattus norvegicus
<308> AI639236
<400> 7407

ttnaaaccc  ctcagggtt  cgtgtaccc  tggctgtcc  agaacttgc  ttgtagacc  60
ggctggctt  caactcaga  aaatctacc  gcctctgtc  ttggagtgc  gggattaaa  120
gctatgcca  catatctag  aatttgttt  tcttttagg  agaaaattg  aggtctgag  180
aaagaacac  ttactcagt  gttcaccag  ccataaact  gtcaactaa  gaagagcat  240
agggggctc  gaggtccta  cccaggttc  tatggacag  ctcagtaac  ctgggtttc  300
gtcacaaaa  ggtccttca  tgtctctgg  acgtggcag  actggaaga  taagcagat  360
tgtcatttt  ttatttcgg  tgagcttag  atagaaaca  taaacaaac  tctacagcc  420
ttcaggagc  aagttatag  gatgaaaaa  gcctgctgt  ggggcacta  gtctctccc  480
ttatcatta  aaatgtaca  taatcata  508



<210> 7408
<211> 56
<212> PRT
<213> Rattus norvegicus
<308> AAF69479
<400> 7408

Glu Val Cys His Arg Gly Ala His Gly Ala Ile His Pro Gly Arg Arg 
  1               5                  10                  15
Val His Leu Gln Pro Leu His Glu Ser Glu Thr Val Gln Gln His Ala 
             20                  25                  30
Gly Glu Thr Asp Pro Val Thr Thr Met Arg Ala Ile Arg Arg Glu Lys 
         35                  40                  45
Asp Gln Phe Lys Val Pro Arg Asp 
     50                  55



<210> 7409
<211> 536
<212> DNA
<213> Rattus norvegicus
<308> AI639245
<400> 7409

ttcaggcac  gcttttttt  aagacaggg  agaccacgc  ggcctcgaa  tctcaggga  60
tcacctgac  ctgtctcct  agtgctggg  tcaaaggcg  gcgccacca  cgcttggct  120
aattcttca  ctttatgag  gattctctc  ttattttat  aggaacaac  agggagtta  180
tgcctaagc  aagattctc  taaactaaa  actctggaa  tctctatac  acccactgc  240
tgtcacctg  accattctc  aaatggctg  cctacatgt  aatgagcgt  actgtacac  300
caacgactt  atctacaag  attcctttc  gcgcaagag  ccgagaaca  ggaaagtca  360
acacgcatt  tgaaacaaa  aaacaaaca  aaatgattg  ttccaaatg  tctaggatg  420
gcttggacc  tcaaataaa  agggcccaa  ttcacataa  ttaagagtg  atgtggggt  480
gaggagaca  ctcagccca  tacaatccc  accactagg  caatagaga  catgaa  536



<210> 7410
<211> 487
<212> DNA
<213> Rattus norvegicus
<308> AI639255
<400> 7410

ttgattgat  gattgattt  tttatttat  tatttattt  tttatttat  tatttattt  60
tgagacttg  tctcactgt  tccatctgg  tgtcctgga  ctcgctctg  cgaccaggc  120
ggcctccga  agctaggac  aaaggtggg  gccagcttc  cacttgctt  ccgtctgta  180
tccatcttt  gtattcgtt  aggtcgtga  ttgtatgaa  aaatatata  tttaattct  240
aaaccatag  tttgttttt  tttttccta  aatacactg  aaaaagaat  aaaagcata  300
attttgtag  acacagagg  cgaatgttc  ggagcgaag  cagagtatt  cccttgtat  360
aaaatcacc  ataaaaaaa  ataaaaaaa  ataaatcac  ttatcccag  gaagagaaa  420
gagacagtg  gagcaagcg  ataggaaac  agcaaaacg  tctgggaga  ctgcttccg  480
tctgggg  487



<210> 7411
<211> 487
<212> DNA
<213> Rattus norvegicus
<308> AI639255
<400> 7411

ttgattgat  gattgattt  tttatttat  tatttattt  tttatttat  tatttattt  60
tgagacttg  tctcactgt  tccatctgg  tgtcctgga  ctcgctctg  cgaccaggc  120
ggcctccga  agctaggac  aaaggtggg  gccagcttc  cacttgctt  ccgtctgta  180
tccatcttt  gtattcgtt  aggtcgtga  ttgtatgaa  aaatatata  tttaattct  240
aaaccatag  tttgttttt  tttttccta  aatacactg  aaaaagaat  aaaagcata  300
attttgtag  acacagagg  cgaatgttc  ggagcgaag  cagagtatt  cccttgtat  360
aaaatcacc  ataaaaaaa  ataaaaaaa  ataaatcac  ttatcccag  gaagagaaa  420
gagacagtg  gagcaagcg  ataggaaac  agcaaaacg  tctgggaga  ctgcttccg  480
tctgggg  487



<210> 7412
<211> 487
<212> DNA
<213> Rattus norvegicus
<308> AI639255
<400> 7412

ttgattgat  gattgattt  tttatttat  tatttattt  tttatttat  tatttattt  60
tgagacttg  tctcactgt  tccatctgg  tgtcctgga  ctcgctctg  cgaccaggc  120
ggcctccga  agctaggac  aaaggtggg  gccagcttc  cacttgctt  ccgtctgta  180
tccatcttt  gtattcgtt  aggtcgtga  ttgtatgaa  aaatatata  tttaattct  240
aaaccatag  tttgttttt  tttttccta  aatacactg  aaaaagaat  aaaagcata  300
attttgtag  acacagagg  cgaatgttc  ggagcgaag  cagagtatt  cccttgtat  360
aaaatcacc  ataaaaaaa  ataaaaaaa  ataaatcac  ttatcccag  gaagagaaa  420
gagacagtg  gagcaagcg  ataggaaac  agcaaaacg  tctgggaga  ctgcttccg  480
tctgggg  487



<210> 7413
<211> 487
<212> DNA
<213> Rattus norvegicus
<308> AI639255
<400> 7413

ttgattgat  gattgattt  tttatttat  tatttattt  tttatttat  tatttattt  60
tgagacttg  tctcactgt  tccatctgg  tgtcctgga  ctcgctctg  cgaccaggc  120
ggcctccga  agctaggac  aaaggtggg  gccagcttc  cacttgctt  ccgtctgta  180
tccatcttt  gtattcgtt  aggtcgtga  ttgtatgaa  aaatatata  tttaattct  240
aaaccatag  tttgttttt  tttttccta  aatacactg  aaaaagaat  aaaagcata  300
attttgtag  acacagagg  cgaatgttc  ggagcgaag  cagagtatt  cccttgtat  360
aaaatcacc  ataaaaaaa  ataaaaaaa  ataaatcac  ttatcccag  gaagagaaa  420
gagacagtg  gagcaagcg  ataggaaac  agcaaaacg  tctgggaga  ctgcttccg  480
tctgggg  487



<210> 7414
<211> 481
<212> DNA
<213> Rattus norvegicus
<308> AI639256
<400> 7414

ttccaaggc  agtaaagtt  attttaata  tgttctctt  caggcagat  aaacaaaca  60
gcaaagtac  tacatagta  atggcagtc  taagtgacc  caaggtgta  tattaactc  120
gactgtgct  gcaaaaatt  cagtctctt  ggatgtaag  tatttttat  acaatgcat  180
gccacagtt  ctccttttt  ttttattaa  aaaaccatg  gggtggagg  ggtcactgg  240
gaagaacta  gaactgatc  agcatggta  tgtagggat  gcctgaatg  accacttca  300
tctaggtga  ccttctgaa  agttggcaa  ggcataaca  gacttgaga  ggaaaacag  360
atgcattac  tgtagaaga  cacacttaa  atttattcc  tgtactaac  taaagaatg  420
attcatctt  tccaacctt  ccctcccaa  aagattcac  ggaatgact  acaggctgc  480
g  481



<210> 7415
<211> 481
<212> DNA
<213> Rattus norvegicus
<308> AI639256
<400> 7415

ttccaaggc  agtaaagtt  attttaata  tgttctctt  caggcagat  aaacaaaca  60
gcaaagtac  tacatagta  atggcagtc  taagtgacc  caaggtgta  tattaactc  120
gactgtgct  gcaaaaatt  cagtctctt  ggatgtaag  tatttttat  acaatgcat  180
gccacagtt  ctccttttt  ttttattaa  aaaaccatg  gggtggagg  ggtcactgg  240
gaagaacta  gaactgatc  agcatggta  tgtagggat  gcctgaatg  accacttca  300
tctaggtga  ccttctgaa  agttggcaa  ggcataaca  gacttgaga  ggaaaacag  360
atgcattac  tgtagaaga  cacacttaa  atttattcc  tgtactaac  taaagaatg  420
attcatctt  tccaacctt  ccctcccaa  aagattcac  ggaatgact  acaggctgc  480
g  481



<210> 7416
<211> 343
<212> DNA
<213> Rattus norvegicus
<308> AI639264
<400> 7416

ttaatgggg  aataatgga  ctttaattg  ttactaaat  aaacctatt  cctgtaagt  60
ttaaaattt  tttattttt  aatgactaa  ttttggcaa  tggaccctc  cctggattt  120
gctcgttaa  tccagttgg  ggttttgaa  aattcggga  gccagtaat  tttgaagcc  180
catggaact  tttgccagc  tgcccaaat  ttgtttgtt  gaccttggg  ttgaggacc  240
gaaaaatgg  gcggactac  gtttgatgc  gtaggaaat  cgatttcag  ttcagtgtc  300
tgggaaagt  caaaagcaa  gcaaaaggt  ttatccagg  aag  343



<210> 7417
<211> 314
<212> DNA
<213> Rattus norvegicus
<308> AI639282
<400> 7417

ttggggaaa  gggaagttt  ttatttaca  gtttaaaat  ggcataaag  tggggcctg  60
cacaacctg  cagctttgc  caatcgctg  tgatgagct  atccacccc  caatcctta  120
agcttccat  tggcaggta  cggcgaatg  tgatgggga  cttccgggc  ttgagttcc  180
tcatggcga  gagcaaagg  tttgtttcc  cctccaggt  caccattac  ggggcacac  240
ttgtaattt  gaaagcccg  gtgcccaac  cttgggctc  ctcgtactt  ggcatgtat  300
gagggggga  accc  314



<210> 7418
<211> 127
<212> PRT
<213> Rattus norvegicus
<308> NP_112625
<400> 7418

Met Ser Asp Asn Glu Asp Asn Phe Asp Gly Asp Asp Phe Asp Asp Val 
  1               5                  10                  15
Glu Glu Asp Glu Gly Leu Asp Asp Leu Glu Asn Ala Glu Glu Glu Gly 
             20                  25                  30
Gln Glu Asn Val Glu Ile Leu Pro Ser Gly Glu Arg Pro Gln Ala Asn 
         35                  40                  45
Gln Lys Arg Ile Thr Thr Pro Tyr Met Thr Lys Tyr Glu Arg Ala Arg 
     50                  55                  60
Val Leu Gly Thr Arg Ala Leu Gln Ile Ala Met Cys Ala Pro Val Met 
 65                  70                  75                  80
Val Glu Leu Glu Gly Glu Thr Asp Pro Leu Leu Ile Ala Met Lys Glu 
                 85                  90                  95
Leu Lys Ala Arg Lys Ile Pro Ile Ile Ile Arg Arg Tyr Leu Pro Asp 
             100                105                110
Gly Ser Tyr Glu Asp Trp Gly Val Asp Glu Leu Ile Ile Ser Asp 
         115                120                125



<210> 7419
<211> 528
<212> DNA
<213> Rattus norvegicus
<308> AI639285
<400> 7419

ttcctatct  ctcattgat  cgtgaattt  tattaaaga  aaatatcat  aacaaatca  60
aaacacgta  acccgctcc  aaaacacag  atagtcccc  gtagaacct  ctccacata  120
aggcaagtg  caattccaa  ctccagtga  atagacatt  aatttttta  cctttagga  180
aacaaattt  accacaaag  gtccacagc  tcggatgag  cgtttgcag  catggaagg  240
atttttttt  atgtgaaat  aatcagctc  cctcctctg  tagttccct  aagcagctt  300
tgggctccc  tctgtgtgg  acagagggg  ggtactgga  gacatccag  gcagggtaa  360
gtgagaagg  tccaatcca  tgtgcgcat  accctgagc  tctggttta  cttcatttc  420
gttaccatg  caaagtcaa  ttgtgggag  gagggttta  ttggctcac  agtccaggt  480
gtggtgtgc  attgcaggc  tttcaaggc  ggaacatga  gttgatgg  528



<210> 7420
<211> 381
<212> DNA
<213> Rattus norvegicus
<308> AI639315
<400> 7420

ttattctgt  aaattaaag  tttatttaa  aaaaaatac  cattataaa  ttgagatac  60
gaaataaaa  cgtaacact  acctactgt  tataaacta  ataaaccac  tcctctcta  120
tcccatcct  cagaggtta  cattgctaa  actttaatg  atattcttt  atatctttt  180
gaaaacttt  cacatacaa  tatatataa  catatcata  acatccagt  tttgagtct  240
acataaact  aatcataca  gtctattat  tgactcaat  tctgtcttc  ttcaacatt  300
tgaaaactt  ttaaacaaa  ctaatcctc  agactttat  ttcttaaat  taacattta  360
tcactggta  ctatctctc  c  381



<210> 7421
<211> 532
<212> DNA
<213> Rattus norvegicus
<308> AI639317
<400> 7421

ttgtagaca  ccaaaccct  tattgtcta  gttacatta  acgcaacac  gtaaaaacc  60
catcaggaa  caaggagac  gaagattcg  agaggtagt  ggaagtctg  aacagtcag  120
aatgtggaa  ttaccacag  ggcagcagg  gttggggga  aaatcaaaa  agattggct  180
aataaataa  gaaacaaat  atattaaat  ctattgttg  gctgacata  acaaattaa  240
aaagcagtc  aatactgat  gccagtgag  cagaaaagc  atgcaccag  ccagcacgc  300
gctggtccc  gagaggcga  cactgggga  ctcgtggcc  tgtggctac  ggaaactgt  360
tctctgtgc  tcgaggggc  ggtcgtcct  agattggct  ctctccagg  aaacggtca  420
ctgcaggga  ctcaggcac  ccttccccc  gccagaccc  gggagggag  ctcaccgga  480
gacagacct  ccagttctc  atgccacgt  cagcttcag  cacagtaaa  ac  532



<210> 7422
<211> 502
<212> DNA
<213> Rattus norvegicus
<308> AI639318
<400> 7422

ttatgattt  taattttat  tacacagct  aaatcattt  cttagtcac  ttgattaca  60
aaacaagtc  acatggtac  gtttaatag  ctttcttaa  tggatctta  aaattttag  120
ggctgacag  ttgctactt  atactcagt  atatttaat  tgtggtaac  tctgcatat  180
tgtagatga  aaatctgtc  gatagtgct  acaggtata  gtactttta  caagtatgg  240
tacttttgt  tctcaggaa  agacagaca  atggttatt  gtcaagtgt  aattcccca  300
agatgggtc  gctatttag  catggagct  agcccttga  gctaaacct  ctgtagcaa  360
actgtgtag  catgttgag  taattgaac  tatctgtat  tctgcattt  ataaaacta  420
tattaagca  atctgaaaa  cataatgga  cccatgact  gagatattt  tattaaaaa  480
aatcttaat  cagtgtatt  ga  502



<210> 7423
<211> 1116
<212> PRT
<213> Rattus norvegicus
<308> CAC10568
<400> 7423

Met Ala Lys Ala Arg Ser Gly Ala Ala Gly Leu Gly Leu Lys Leu Phe 
  1               5                  10                  15
Leu Leu Leu Pro Leu Leu Gly Glu Ala Pro Leu Gly Leu Cys Phe Ser 
             20                  25                  30
Arg Asp Ala Tyr Trp Glu Arg Leu Tyr Val Asp Gln Pro Ala Gly Thr 
         35                  40                  45
Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Gly Glu Val Pro 
     50                  55                  60
Ser Phe Arg Leu Gly Gln Tyr Leu Tyr Gly Val Tyr Arg Thr Arg Leu 
 65                  70                  75                  80
His Glu Asn Asp Trp Ile His Ile Asp Ala Gly Thr Gly Leu Leu Tyr 
                 85                  90                  95
Leu Asn Gln Ser Leu Asp His Ser Ser Trp Glu Gln Leu Ser Ile Arg 
             100                105                110
Asn Gly Gly Phe Pro Leu Leu Thr Val Phe Leu Gln Val Phe Leu Gly 
         115                120                125
Ser Thr Ala Gln Arg Glu Gly Glu Cys His Trp Pro Gly Cys Ala Arg 
     130                135                140
Val Tyr Phe Ser Phe Ile Asn Asp Thr Phe Pro Asn Cys Ser Ser Phe 
 145                150                155                160
Lys Ala Arg Asp Leu Cys Thr Pro Glu Thr Gly Val Ser Phe Arg Ile 
                 165                170                175
Arg Glu Asn Arg Pro Pro Gly Thr Phe Tyr Gln Phe Arg Met Leu Pro 
             180                185                190
Val Gln Phe Leu Cys Pro Asn Ile Ser Val Lys Tyr Lys Leu Leu Glu 
         195                200                205
Gly Asp Gly Leu Pro Phe Arg Cys Asp Pro Asp Cys Leu Glu Val Ser 
     210                215                220
Thr Arg Trp Ala Leu Asp Arg Glu Leu Gln Glu Lys Tyr Val Leu Glu 
 225                230                235                240
Ala Glu Cys Ala Val Ala Gly Pro Gly Ala Asn Lys Glu Lys Val Ala 
                 245                250                255
Val Ser Phe Pro Val Thr Val Tyr Asp Asp Glu Asp Asp Ser Pro Pro 
             260                265                270
Thr Phe Ser Gly Gly Val Gly Thr Ala Ser Ala Val Val Glu Phe Lys 
         275                280                285
Arg Lys Glu Gly Thr Val Val Ala Thr Leu Gln Val Phe Asp Ala Asp 
     290                295                300
Val Val Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu 
 305                310                315                320
Leu Ser Gly Asp Ser Trp Ala Gln Gln Thr Phe Arg Val Glu His Thr 
                 325                330                335
Pro Asn Glu Thr Leu Val Gln Ser Asn Asn Asn Ser Val Arg Ala Thr 
             340                345                350
Met His Asn Tyr Arg Leu Val Leu Asn Arg Ser Leu Ser Ile Ser Glu 
         355                360                365
Ser Arg Val Leu Gln Leu Val Val Leu Val Asn Asp Ser Asp Phe Gln 
     370                375                380
Gly Pro Gly Ser Gly Phe Leu Phe Leu His Phe Asn Val Ser Val Leu 
 385                390                395                400
Pro Val Thr Leu Asn Leu Pro Met Ala Tyr Ser Phe Pro Val Asn Arg 
                 405                410                415
Arg Ala Arg Arg Tyr Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys 
             420                425                430
Gln Glu Phe Ser Gly Val Ser Ile Gln Tyr Lys Leu Gln Pro Ser Ser 
         435                440                445
Thr Asn Cys Ser Ala Leu Gly Val Val Thr Ser Thr Glu Asp Thr Ser 
     450                455                460
Gly Thr Leu Tyr Val Asn Asp Thr Glu Ala Leu Arg Arg Pro Glu Cys 
 465                470                475                480
Thr Glu Leu Gln Tyr Thr Val Val Ala Thr Asp Arg Gln Thr Arg Arg 
                 485                490                495
Gln Thr Gln Ala Ser Leu Val Val Thr Val Glu Gly Thr Tyr Ile Ala 
             500                505                510
Glu Glu Val Gly Cys Pro Lys Ser Cys Ala Val Asn Lys Arg Arg Pro 
         515                520                525
Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu 
     530                535                540
Trp Arg Gln Gly Asp Gly Lys Gly Thr Thr Arg Asn Phe Ser Thr Cys 
 545                550                555                560
Ser Pro Ser Thr Arg Thr Cys Pro Asp Gly His Cys Asp Ala Leu Glu 
                 565                570                575
Ser Arg Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Pro Ile 
             580                585                590
Val Gly Gly His Glu Arg Gly Glu Arg Gln Gly Ile Lys Ala Gly Tyr 
         595                600                605
Gly Ile Cys Asn Cys Phe Pro Asp Glu Lys Lys Cys Phe Cys Glu Pro 
     610                615                620
Glu Asp Ser Gln Ala Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile 
 625                630                635                640
Thr Ala Ala Val Leu Phe Ser Phe Ile Ile Ser Val Leu Leu Ser Thr 
                 645                650                655
Phe Cys Ile His Arg Tyr His Lys His Xaa Xaa Lys Pro Pro Ile Xaa 
             660                665                670
Ser Ala Glu Met Thr Phe Cys Arg Pro Ala Gln Gly Phe Pro Ile Ser 
         675                680                685
Tyr Ser Ser Ser Gly Xaa Arg Arg Pro Ser Leu Asp Ser Met Glu Asn 
     690                695                700
Gln Val Ser Val Asp Ser Phe Lys Ile Pro Glu Asp Pro Lys Trp Glu 
 705                710                715                720
Phe Pro Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu 
                 725                730                735
Phe Gly Lys Val Val Lys Ala Thr Ala Phe Arg Leu Lys Asp Arg Ala 
             740                745                750
Gly Tyr Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Gln 
         755                760                765
Ser Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn Leu Leu Lys Gln Val 
     770                775                780
Asn His Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly 
 785                790                795                800
Pro Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly 
                 805                810                815
Phe Leu Arg Asp Ser Arg Lys Ile Gly Pro Ala Tyr Val Ser Ser Gly 
             820                825                830
Gly Ser Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Val Leu 
         835                840                845
Thr Met Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Arg Gly Met 
     850                855                860
Gln Tyr Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg 
 865                870                875                880
Asn Ile Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly 
                 885                890                895
Leu Ser Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Lys Ser Xaa 
             900                905                910
Gly Arg Ile Pro Val Asn Trp Met Ala Ile Asn Ser Leu Ser Asp His 
         915                920                925
Phe Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp 
     930                935                940
Glu Ile Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu 
 945                950                955                960
Arg Leu Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asn 
                 965                970                975
Asn Cys Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln 
             980                985                990
Glu Pro Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu 
         995                1000                1005
Lys Met Met Val Lys Ser Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr 
     1010                1015                1020
Pro Ser Asp Ser Leu Leu Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr 
 1025                1030                1035                1040
Pro Leu Val Asp Cys Asn Ser Ala Pro Leu Pro Arg Ser Leu Pro Ser 
                 1045                1050                1055
Thr Trp Ile Glu Asn Lys Leu Tyr Gly Met Ser Asp Pro Asn Trp Pro 
             1060                1065                1070
Gly Glu Ser Pro Val Pro Leu Thr Arg Ala Asp Gly Thr Ser Thr Gly 
         1075                1080                1085
Phe Pro Arg Tyr Ala Asn Asp Ser Val Tyr Ala Asn Trp Met Val Ser 
     1090                1095                1100
Pro Ser Ala Ala Lys Leu Met Asp Thr Phe Asp Ser 
 1105                1110                1115



<210> 7424
<211> 7005
<212> DNA
<213> Homo sapiens
<308> NM_020630
<400> 7424

gcttcagtc  cgcgaccga  gcagggcgc  cagcagcgc  gagtgcccc  gaacgtgcg  60
cgcgccccc  gtgtccgtc  cgtccgccg  gccccgggc  gggatgggg  ggccagact  120
agcgccgca  ccgccatcc  gacccgccg  ccctagccg  agtccctcc  gccgtggcc  180
cagcgcgca  gggcgatgg  gaaggcgac  tccggtgcc  cggggctgc  tctgctgtt  240
ctgctgctg  tgccgctgc  aggcaaagt  gcattgggc  tctacttct  gagggatgc  300
tactgggag  agctgtatg  ggaccaggc  gccggcacg  ccttgctgt  cgtccatgc  360
ctgcgggac  cccctgagg  ggtgcccag  ttccgcctg  gccagcatc  ctacggcac  420
taccgcaca  ggctgcatg  gaacaactg  atctgcatc  aggaggaca  cggcctcct  480
taccttaac  ggagcctgg  ccatagctc  tgggagaag  tcagtgtcc  caaccgcgg  540
tttcccctg  tcaccgtct  cctcaaggt  ttcctgtca  ccacatccc  tcgtgaggg  600
gagtgccag  ggccaggct  tgcccgcgt  tacttctcc  tcttcaaca  ctcctttcc  660
gcctgcagc  ccctcaagc  ccgggagct  tgcttccca  agacaaggc  ctccttccg  720
attcgggag  accgacccc  aggcacctt  caccagttc  gcctgctgc  tgtgcagtt  780
ttgtgcccc  acatcagcg  ggcctacag  ctcctggag  gtgagggtc  gcccttccg  840
tgcgccccg  acagcctgg  ggtgagcac  cgctgggcc  tggaccgcg  gcagcggga  900
aagtacgag  tggtggccg  gtgcaccgt  cacgccggc  cgcgcgagg  ggtggtgat  960
gtgcccttc  cggtgaccg  gtacgacga  gacgactcg  cgcccacct  ccccgcggg  1020
gtcgacacc  ccagcgccg  ggtggagtt  aagcggaag  aggacaccg  ggtggccac  1080
ctgcgtgtc  tcgatgcag  cgtggtacc  gcatcaggg  agctggtga  gcggtacac  1140
agcacgctg  tccccgggg  cacctgggc  cagcagacc  tccgggtgg  acactggcc  1200
aacgagacc  cggtccagg  caacggcag  ttcgtgcgg  cgaccgtac  tgactatag  1260
ctggttctc  accggaacc  ctccatctc  gagaaccgc  ccatgcagc  ggcggtgct  1320
gtcaatgac  cagacttcc  gggcccagg  gcgggcgtc  tcttgctcc  cttcaacgt  1380
tcggtgctg  cggtcagcc  gcacctgcc  agtacctac  ccctctccg  gagcaggag  1440
gctcgccga  ttgcccaga  cgggaaagt  tgtgtggaa  actgccagg  attcagtgg  1500
atcaacgtc  agtacaagc  gcattcctc  ggtgccaac  gcagcacgc  aggggtggt  1560
acctcagcc  aggacacct  ggggatcct  tttgtgaat  acaccaagg  cctgcggcg  1620
cccaagtgt  ccgaacttc  ctacatggt  gtggccacc  accagcaga  ctctaggca  1680
gcccaggcc  agctgcttg  aacagtgga  gggtcatat  tggccgagg  ggcgggctg  1740
cccctgtcc  gtgcagtca  caagagacg  ctggagtgt  aggagtgtg  cggcctggg  1800
tccccaaca  gcaggtgtg  gtggaggca  ggagatggc  aagggatca  caggaactt  1860
tccacctgc  ctcccagca  caagacctg  cccgacggc  actgcgatg  tgtggagac  1920
caagacatc  acatttgcc  tcaggactg  ctccggggc  gcattgttg  gggacacga  1980
cctggggag  cccggggga  taaagctgg  tatggcacc  gcaactgct  ccctgagga  2040
gagaagtgc  tctgcgagc  cgaagacat  caggatcca  tgtgcgacg  gctgtgccg  2100
acggtgatc  cagccgctg  cctcttctc  ttcatcgtc  cggtgctgc  gtctgcctt  2160
tgcatccac  gctaccaca  gtttgccca  aagccaccc  tctcctcag  tgagatgac  2220
ttccggagg  ccgcccagg  cttcccggt  agctactcc  cttccggtg  ccgccggcc  2280
tcgctggac  ccatggaga  ccaggtctc  gtggatgcc  tcaagatcc  ggaggatcc  2340
aagtgggaa  tccctcgga  gaacttggt  cttggaaaa  ctctaggag  aggcgaatt  2400
ggaaaagtg  tcaaggcaa  ggccttcca  ctgaaaggc  gagcagggt  caccacggt  2460
gccgtgaag  tgctgaaag  gaacgcctc  ccgagtgag  tgcgagacc  gctgtcaga  2520
ttcaacgtc  tgaagcagg  caaccaccc  catgtcatc  aattgtatg  ggcctgcag  2580
caggatggc  cgctcctcc  catcgtgga  tacgccaaa  acggctccc  gcggggctt  2640
ctccgcgag  gccgcaaag  ggggcctgg  tacctgggc  gtggaggca  ccgcaactc  2700
agctccctg  accacccgg  tgagcgggc  ctcaccatg  gcgacctca  ctcatttgc  2760
tggcagatc  cacagggga  gcagtatct  gccgagatg  agctcgttc  tcgggactt  2820
gcagccaga  acatcctgg  agctgaggg  cggaagatg  agatttcgg  tttcggctt  2880
tcccgagat  tttatgaag  ggattccta  gtgaagagg  gccagggtc  gattccagt  2940
aaatggatg  caattgaat  cctttttga  catatctac  ccacgcaaa  tgatgtatg  3000
tcttttggt  tcctgctgt  ggagatcgt  accctaggg  gaaacccct  tcctgggat  3060
cctcctgag  ggctcttca  ccttctgaa  accggccac  ggatggaga  gccagacaa  3120
tgcagcgag  agatgtacc  cctgatgct  caatgctgg  agcaggagc  ggacaaaag  3180
ccggtgttt  cggacatca  caaagacct  gagaagatg  tggttaaga  gagagacta  3240
ttggacctt  cggcgtcca  tccatctga  tccctgatt  atgacgacg  cctctcaga  3300
gaggagaca  cgctggtgg  ctgtaataa  gcccccctc  ctcgagccc  cccttccac  3360
tggattgaa  acaaactct  tggtagaat  tcccatgca  ttactagat  ctagcaccg  3420
tgtcccctt  gcactatcc  tcctctctg  gatgctttt  aaaaatgtt  ctggtctga  3480
caaaaccaa  gtctgctct  aaccttttt  tttgtaaat  tctgacttt  catccagtt  3540
acatttagg  attattgca  ctatgtttt  ctaaaagga  gtgaaaata  gtgtaatta  3600
cacattgcc  agcaactta  gatggtaga  gaaaaaaca  atcagggcg  aactctcag  3660
ggagaccaa  aacaggttg  ataaggcgc  tctggggtg  gaatcaagt  atagtactt  3720
tactttaac  aagtggata  atatacaaa  ctggggagg  attcagttg  gaaaggagc  3780
accagcacc  ctcagcctg  actgggagc  cagccaggt  cccccagac  cctcctggg  3840
aggcaggtg  ctctcagag  ccacccggc  ctggcgagc  gccactggc  aagcctcag  3900
cccagtccc  gccacatgt  ctccatcag  ggtagcgag  ttgcaggag  tggctggcc  3960
tgggaggac  cacccccac  gctgttttc  catcctttc  cttacccac  ttcaggacg  4020
ttgtcactt  tgaagtcag  gctaaagct  gagcagttg  tttttgaaa  aacatggtc  4080
gtggtgctg  ggtcttaca  tggacagta  atatggttc  tgccaaaac  ccttctttt  4140
tctttgatt  aatactaga  attttttct  tttcctaac  tcatcattg  ttgtttgaa  4200
tcttggagt  tcaagcatt  ttttcaagc  gagacggtt  cttttgcat  cctcctgac  4260
cactgactc  tcactggct  tgtgtctag  gccacactc  atttgtgct  acgatgcta  4320
gaggctggc  cgtgtgcac  ctcgatttg  aaggtcctc  tctccgttg  aggctcaga  4380
aacagacga  tgcctcctt  acgttagag  atgttttat  gaacgtttc  gctgcagta  4440
gccattgag  gcagcagtg  gctgttgcc  tacactgcc  tagaaaaag  gttaagcag  4500
tcgacaaat  tacatcaga  tagagagtc  caagttcat  aaagtcaaa  ttggtagtg  4560
ctgttaagt  acatttacc  agagagcac  tgatatttc  cctaactat  acagtgttt  4620
tggaaacct  gaacacaaa  ccattaata  aattggcac  gaaaccacg  gtttggttt  4680
aacatcaaa  ggagttttg  caaggcctt  ctgtctgca  ttgaagttt  ggttcttca  4740
tgcagaaca  atgatctgt  ttcattttt  ggcatgtca  acccgaact  gcctggaga  4800
agtcctgta  cactcacga  agctgatgg  actaacact  ggtttccaa  atatccaaa  4860
gatagtgta  atgctaact  gatgctttc  ccctcagcg  caaaattaa  ggacacgtt  4920
gatagttaa  atttctttg  gaaaggtaa  ggactcaca  ggggaagaa  catgctgag  4980
atggaaagt  taccggccc  ttctttgtg  acgtcacat  ggccgagcc  tgttcagtt  5040
ccaggtggc  gactcgttt  tggtagttt  ttttaactt  caaggtggt  ttacttctg  5100
tagccggtg  ttttccctc  tagcagaca  gccacaccg  gtaagagct  tgagtctta  5160
tggttaagc  ttcctttct  ttcagtgcc  agcagcacc  agtgttggt  tgtgtccat  5220
agtgaccac  aacattctg  gttcacatg  gtgggtcca  cacttacta  ctggtgtat  5280
aaattggac  tgaactgtt  gatttttct  gttgccgcc  aacaaggca  aaaaattta  5340
acatgaagc  cacacacaa  aaaggcagt  ggaaaaatg  tggccctga  gacctgtcc  5400
tattcagaa  gagagactg  ggggggggc  tgggggtag  gtcaatgcc  ctccagggc  5460
ggaggggaa  aggggcccc  aggatgggc  tgggctcag  attcgagat  ttgagaatg  5520
tttttttta  atcatgcaa  ctttcctta  gaagacatt  ggttttcat  atgattaag  5580
tgattccta  atttagcac  atggagaga  tccatgcca  ctttactat  tggatggtg  5640
tatcaggga  gagggctca  aagacacat  tgtcccccg  gcccaccac  tcatcctca  5700
gtgttcggt  ctgagcagc  actacccct  atgagaaca  tatgaagaa  gggggctgt  5760
ggagtccca  aattgctga  agcagaggc  ttgctgctg  gaatcccac  tgccaccag  5820
ctgcagcac  ccccacagc  aagtagagg  gaaagcagt  gctcatcct  cctgttagg  5880
gcaggtagg  cttgtactc  ctttaattt  aatcttatc  acttactca  aaagggaca  5940
gctagctag  tgtgttaga  gtagcaatg  caatgacca  ggactgcta  acctctgat  6000
acaattctg  tgtgaaaaa  atggtgttt  gctcttata  agcctgtgt  aaaggccca  6060
ggatcagct  ttcctgtgt  tgtaattta  tgctgctac  agatgtttc  gtttcttag  6120
ttctgacca  gactcataa  cttcttgtc  ttcttcatt  cttgtttgt  gtcacagat  6180
cacaacact  ctccagtct  gtgggggca  cttttggga  gtctcagca  ctcttctgg  6240
tgtgttgtc  gcactgtaa  ttcgcagaa  agagtcgga  taccaaaac  ctgcctgct  6300
ttcagactt  aagcactga  aggacttaa  atagtctca  tcaaatact  tattttata  6360
aggcatttc  caaaaacag  aaaattgtg  cattttgtg  ggccaaggc  tggatgcgt  6420
tgtaataga  ccttgtggt  tgtgcgcac  cacccagag  gagagtttg  aaaatgctt  6480
ttggacacg  aacctggct  taatttggg  tgtttttca  atacactgt  ataagttct  6540
ttacaaata  ctatagaca  ggtaaactt  tggttttca  atatgctta  tgatagtct  6600
actaaatgc  gaaataaga  taaactttc  caaattatt  aaaatgcct  cacagtaag  6660
gtgaattgc  gcaacaggt  tgttctcag  agggtaaga  ctccaggtc  aaacagctg  6720
cccagtgat  gggaattta  ccttgacca  tttatcctt  accaataac  taattgtct  6780
ttcctgagt  ataaaagtc  ccatcctta  tagctctac  ggaattttc  tacacgtaa  6840
tgcagaagt  actaagtat  aagtattac  gagtattaa  tagtaatct  tcagttatt  6900
aaatttgta  aatctattt  tgaaaggtc  ttaaaccag  tcatgttcc  ttttttgta  6960
tcaaggtga  taagaaaat  agttgtgta  ataaaatca  gtatc  7005



<210> 7425
<211> 1114
<212> PRT
<213> Homo sapiens
<308> P07949
<400> 7425

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
  1               5                  10                  15
Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
             20                  25                  30
Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
         35                  40                  45
Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
     50                  55                  60
Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
 65                  70                  75                  80
His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                 85                  90                  95
Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
             100                105                110
Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
         115                120                125
Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
     130                135                140
Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
 145                150                155                160
Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                 165                170                175
Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
             180                185                190
Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
         195                200                205
Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
     210                215                220
Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
 225                230                235                240
Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                 245                250                255
Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
             260                265                270
Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
         275                280                285
Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
     290                295                300
Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
 305                310                315                320
Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                 325                330                335
Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
             340                345                350
Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
         355                360                365
Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
     370                375                380
Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
 385                390                395                400
Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                 405                410                415
Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
             420                425                430
Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
         435                440                445
Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
     450                455                460
Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
 465                470                475                480
Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                 485                490                495
Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
             500                505                510
Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
         515                520                525
Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
     530                535                540
Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
 545                550                555                560
Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                 565                570                575
Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
             580                585                590
Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
         595                600                605
Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
     610                615                620
Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
 625                630                635                640
Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                 645                650                655
Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
             660                665                670
Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
         675                680                685
Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
     690                695                700
Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
 705                710                715                720
Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                 725                730                735
Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
             740                745                750
Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
         755                760                765
Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
     770                775                780
Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
 785                790                795                800
Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                 805                810                815
Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
             820                825                830
Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
         835                840                845
Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
     850                855                860
Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
 865                870                875                880
Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                 885                890                895
Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
             900                905                910
Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
         915                920                925
Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
     930                935                940
Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
 945                950                955                960
Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                 965                970                975
Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
             980                985                990
Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu Lys Met 
         995                1000                1005
Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr Pro Ser 
     1010                1015                1020
Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr Pro Leu 
 1025                1030                1035                1040
Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser Thr Trp 
                 1045                1050                1055
Ile Glu Asn Lys Leu Tyr Gly Met Ser Asp Pro Asn Trp Pro Gly Glu 
             1060                1065                1070
Ser Pro Val Pro Leu Thr Arg Ala Asp Gly Thr Asn Thr Gly Phe Pro 
         1075                1080                1085
Arg Tyr Pro Asn Asp Ser Val Tyr Ala Asn Trp Met Leu Ser Pro Ser 
     1090                1095                1100
Ala Ala Lys Leu Met Asp Thr Phe Asp Ser 
 1105                1110



<210> 7426
<211> 322
<212> DNA
<213> Rattus norvegicus
<308> AI639320
<400> 7426

ttatttttt  ttggtggcc  ggccaaagc  tcggtacag  ctcagcaaa  ttctgatca  60
taagttgaa  tccatttgg  ttctctcta  tgccaaggt  agagcagca  aggcacatg  120
aagcagaat  ctagagtac  caaagcaca  tgtacactg  ttaggtttt  tggattatt  180
gtttccaga  gagcctgcc  cccacttca  tccatataa  gtagtttaa  tattggctt  240
agaggaagt  tctgaagat  ggcaagttc  atccatttg  cttattcat  tcgttggtc  300
cacctttcc  tgcgtgtgg  tg  322



<210> 7427
<211> 513
<212> DNA
<213> Rattus norvegicus
<308> AI639324
<400> 7427

ttaaagttt  tactaaatg  ttattttat  ttcaagata  agcctatac  caattgaat  60
tggaaataa  taactagaa  tgctctgga  actctattt  cccttcaaa  tcatttttt  120
aaggtcatg  atttttatt  aaatcaata  gccaaatat  aacactaag  aaagaagaa  180
tacatctta  tacagaaac  taatcttct  tgactaagg  tttagctgg  attatgata  240
cgaaaacac  caagataca  cactttagc  ggctgactc  gacggctct  ctggagaag  300
aaaaggcac  gactgaagg  caatggtga  gagcagagg  catgggctc  gtcacctga  360
acagagaac  cagtcagga  aagtgaaca  aatcagtgc  aaatgactt  tttaaatta  420
gatgtataa  cataggcta  aaaggcatt  cttttggaa  catctttgc  tatttcttc  480
atatataaa  ctttgtata  aatttccat  ttc  513



<210> 7428
<211> 2360
<212> DNA
<213> Homo sapiens
<308> AF177339
<400> 7428

tgtcagtaa  tggaaaagg  aagactcca  ttcgaaaga  gtacaactc  catcagatg  60
gccagtcga  gcagtttcc  ctcgaggaa  gcagctgtg  gaaaggctg  caggtcacc  120
gtgagcaga  caaagccga  atgaaagca  ctagggata  tcctgaaaa  aaaaaaaac  180
aggatgttt  tcccagctg  agcagcacc  ccgccagca  agtgggaaa  tccagctca  240
acaacactg  ttctcaaag  cccgacttt  taaggacgg  gaacagcgg  ggctcttcc  300
agcctagcc  tacagaagt  gatgtgtcc  ggcagtgtg  ctgctcccc  ggtgggtca  360
aggactctg  ggccatgga  gagggagat  cagagagtt  tgtctgccc  gatgcttgc  420
gtcacaggc  ccaggaatt  ccaaaggag  actagcagg  gttctgatg  ggaacgtcc  480
tcaaccagc  gagcctgtg  tgtgaatgg  ccggatggt  cgagatccg  cttttcctt  540
aggactctg  cacaagggg  gtcttcagg  ccagcacat  atgagagga  taatgggag  600
ggctctggg  ctacaggtg  ggacaggag  gggagctcc  agcctgaga  ttgtgacgt  660
cagtctaat  aagactacc  tcggaggcc  ctaaccagg  ccaggagca  actgtccca  720
gtactgctg  tatctgagt  agaagtagc  aaaacaaag  cacgtcacg  catgaaacg  780
aagcggaca  cagataaat  cactagtac  agtgatcct  tgatcgagg  tgaccatgt  840
caggttctt  tattaaaat  caagaatct  gttggagtc  ctatgacca  ttgtggaat  900
acagatcta  tgctaaaag  ctgtccaaa  atgatgttc  tccatgcta  caggtgcag  960
gtactaaaa  atttaaagg  agaaaatgc  ccaattgta  accgatttg  ctatgcaca  1020
tgcaagaaa  tgaacatgg  tcaggtact  gaccagata  taagaatgc  acccgagag  1080
aaccgcatc  tatacctac  cccaatgca  caggtggac  ctctaactt  ggagcagaa  1140
ctatttagt  gtccctacc  ctatcacat  tgtattatc  atgaattca  taaccctcc  1200
aatgtccgg  ataaggtgc  cattcgcag  tggatggac  ctatagcaa  catcaatca  1260
gagctcatt  aatatgaat  cttccctga  gccactcga  gtgaagaag  cttaaagaa  1320
taccccaag  acccctggg  gagagaaat  tatacttta  aaggtgttg  ggatggagc  1380
ccatattcc  tgatttctg  cttcccttg  ctgaggtca  tacgagctg  agagcccaa  1440
agcttcgct  gatacgact  tgaagacga  gaagaaagc  ctatctatg  tcctagaag  1500
aaaggacag  tgtctgcag  catctgtat  gaaacaata  gagaggaaa  ttcagagat  1560
cgtcagatg  agaagggtg  atttcagcg  gtagtggca  tttttatcc  ctattgtga  1620
gtcaatgga  agccagttg  agatgacta  atttaattg  tccctcctc  tttccagct  1680
ttttgtcag  aagcaagta  ggccatcca  ctgccagag  gctccacag  gacttgagg  1740
atgcagttg  gaggtcctg  ctcggtttg  tatataggg  atatataag  aacatcgaa  1800
ttgtataca  agatttgta  ataaaaaat  tacaaagac  cttcctaaa  taccaactt  1860
atatcatat  tttatacaa  ttaatttaa  aattcattt  aaggaagac  gataatttg  1920
aagactttt  tttttcttg  cttaattca  gaagtatca  tttttgact  agtctccat  1980
tacttcatt  ttaatgatt  ttgtcatcc  tttaaatct  tgccttttt  ttcttgagc  2040
aagctgttt  agtaaacct  ttgaagagt  tttgtgtct  gtgtgcttt  ttgttgtta  2100
taaaacacc  actaaacct  atagtcaag  caaggctct  tgtttctgt  caaagctgt  2160
gttctttct  agtattata  ttgccatgt  tcttaaaat  aagtaaaaa  acttatgag  2220
ttaaaaaaa  gtgagtttg  gagggaaat  gaaaagttt  cagagtatt  ctagtaatt  2280
tttccacat  gaattgtgt  tatgcttta  cttgaatat  aaataaaag  ttattaaaa  2340
ctttaaaaa  aaaaaaaaaa  2360



<210> 7429
<211> 445
<212> PRT
<213> Homo sapiens
<308> AF177339
<400> 7429

Met Cys Pro Gly Ser Val Pro Ala Pro Pro Val Gly Gln Arg Thr Leu 
  1               5                  10                  15
Arg Pro Trp Arg Arg Glu Met Gln Arg Val Leu Ser Ala Gln Met Leu 
             20                  25                  30
Ala Val Thr Gly Pro Arg Asn Ser Gln Arg Arg Thr Ser Arg Cys Ser 
         35                  40                  45
Asp Glu Glu Arg Pro Ser Thr Ser Arg Ala Cys Val Val Asn Gly Pro 
     50                  55                  60
Asp Gly Thr Arg Ser Ala Phe Ser Phe Arg Thr Leu Pro Gln Gly Gly 
 65                  70                  75                  80
Ser Ser Gly Pro Ala His Asp Glu Arg Thr Asn Gly Ser Gly Ser Gly 
                 85                  90                  95
Ala Thr Gly Glu Asp Arg Arg Gly Ser Ser Gln Pro Glu Ser Cys Asp 
             100                105                110
Val Gln Ser Asn Glu Asp Tyr Pro Arg Arg Pro Leu Thr Arg Ala Arg 
         115                120                125
Ser Arg Leu Ser His Val Leu Leu Val Ser Glu Ser Glu Val Ala Lys 
     130                135                140
Thr Lys Pro Arg His Ala Met Lys Arg Lys Arg Thr Ala Asp Lys Ser 
 145                150                155                160
Thr Ser Thr Ser Asp Pro Val Ile Glu Asp Asp His Val Gln Val Leu 
                 165                170                175
Val Leu Lys Ser Lys Asn Leu Val Gly Val Thr Met Thr Asn Cys Gly 
             180                185                190
Ile Thr Asp Leu Val Leu Lys Asp Cys Pro Lys Met Met Phe Ile His 
         195                200                205
Ala Thr Arg Cys Arg Val Leu Lys His Leu Lys Val Glu Asn Ala Pro 
     210                215                220
Ile Val Asn Arg Phe Asp Tyr Ala Gln Cys Lys Lys Leu Asn Met Asp 
 225                230                235                240
Gln Val Leu Asp Gln Ile Leu Arg Met Pro Pro Glu Arg Asn Arg Ile 
                 245                250                255
Ile Tyr Leu Arg Pro Met Gln Gln Val Asp Thr Leu Thr Leu Glu Gln 
             260                265                270
Lys Leu Phe Ser Gly Pro Tyr Pro Tyr His Ile Cys Ile Ile His Glu 
         275                280                285
Phe Ser Asn Pro Pro Asn Val Arg Asn Lys Val Arg Ile Arg Ser Trp 
     290                295                300
Met Asp Thr Ile Ala Asn Ile Asn Gln Glu Leu Ile Lys Tyr Glu Phe 
 305                310                315                320
Phe Pro Glu Ala Thr Arg Ser Glu Glu Asp Leu Lys Lys Tyr Pro Lys 
                 325                330                335
Tyr Pro Trp Gly Arg Glu Ile Tyr Thr Leu Glu Gly Val Val Asp Gly 
             340                345                350
Ala Pro Tyr Ser Met Ile Ser Asp Phe Pro Trp Leu Arg Ser Leu Arg 
         355                360                365
Ala Ala Glu Pro Asn Ser Phe Ala Arg Tyr Asp Phe Glu Asp Asp Glu 
     370                375                380
Glu Ser Thr Ile Tyr Ala Pro Arg Arg Lys Gly Gln Leu Ser Ala Asp 
 385                390                395                400
Ile Cys Met Glu Thr Ile Gly Glu Glu Ile Ser Glu Met Arg Gln Met 
                 405                410                415
Lys Lys Gly Val Phe Gln Arg Val Val Ala Ile Phe Ile His Tyr Cys 
             420                425                430
Asp Val Asn Gly Glu Pro Val Glu Asp Asp Tyr Ile Ter 
         435                440                445



<210> 7430
<211> 513
<212> DNA
<213> Rattus norvegicus
<308> AI639324
<400> 7430

ttaaagttt  tactaaatg  ttattttat  ttcaagata  agcctatac  caattgaat  60
tggaaataa  taactagaa  tgctctgga  actctattt  cccttcaaa  tcatttttt  120
aaggtcatg  atttttatt  aaatcaata  gccaaatat  aacactaag  aaagaagaa  180
tacatctta  tacagaaac  taatcttct  tgactaagg  tttagctgg  attatgata  240
cgaaaacac  caagataca  cactttagc  ggctgactc  gacggctct  ctggagaag  300
aaaaggcac  gactgaagg  caatggtga  gagcagagg  catgggctc  gtcacctga  360
acagagaac  cagtcagga  aagtgaaca  aatcagtgc  aaatgactt  tttaaatta  420
gatgtataa  cataggcta  aaaggcatt  cttttggaa  catctttgc  tatttcttc  480
atatataaa  ctttgtata  aatttccat  ttc  513



<210> 7431
<211> 2360
<212> DNA
<213> Homo sapiens
<308> AF177339
<400> 7431

tgtcagtaa  tggaaaagg  aagactcca  ttcgaaaga  gtacaactc  catcagatg  60
gccagtcga  gcagtttcc  ctcgaggaa  gcagctgtg  gaaaggctg  caggtcacc  120
gtgagcaga  caaagccga  atgaaagca  ctagggata  tcctgaaaa  aaaaaaaac  180
aggatgttt  tcccagctg  agcagcacc  ccgccagca  agtgggaaa  tccagctca  240
acaacactg  ttctcaaag  cccgacttt  taaggacgg  gaacagcgg  ggctcttcc  300
agcctagcc  tacagaagt  gatgtgtcc  ggcagtgtg  ctgctcccc  ggtgggtca  360
aggactctg  ggccatgga  gagggagat  cagagagtt  tgtctgccc  gatgcttgc  420
gtcacaggc  ccaggaatt  ccaaaggag  actagcagg  gttctgatg  ggaacgtcc  480
tcaaccagc  gagcctgtg  tgtgaatgg  ccggatggt  cgagatccg  cttttcctt  540
aggactctg  cacaagggg  gtcttcagg  ccagcacat  atgagagga  taatgggag  600
ggctctggg  ctacaggtg  ggacaggag  gggagctcc  agcctgaga  ttgtgacgt  660
cagtctaat  aagactacc  tcggaggcc  ctaaccagg  ccaggagca  actgtccca  720
gtactgctg  tatctgagt  agaagtagc  aaaacaaag  cacgtcacg  catgaaacg  780
aagcggaca  cagataaat  cactagtac  agtgatcct  tgatcgagg  tgaccatgt  840
caggttctt  tattaaaat  caagaatct  gttggagtc  ctatgacca  ttgtggaat  900
acagatcta  tgctaaaag  ctgtccaaa  atgatgttc  tccatgcta  caggtgcag  960
gtactaaaa  atttaaagg  agaaaatgc  ccaattgta  accgatttg  ctatgcaca  1020
tgcaagaaa  tgaacatgg  tcaggtact  gaccagata  taagaatgc  acccgagag  1080
aaccgcatc  tatacctac  cccaatgca  caggtggac  ctctaactt  ggagcagaa  1140
ctatttagt  gtccctacc  ctatcacat  tgtattatc  atgaattca  taaccctcc  1200
aatgtccgg  ataaggtgc  cattcgcag  tggatggac  ctatagcaa  catcaatca  1260
gagctcatt  aatatgaat  cttccctga  gccactcga  gtgaagaag  cttaaagaa  1320
taccccaag  acccctggg  gagagaaat  tatacttta  aaggtgttg  ggatggagc  1380
ccatattcc  tgatttctg  cttcccttg  ctgaggtca  tacgagctg  agagcccaa  1440
agcttcgct  gatacgact  tgaagacga  gaagaaagc  ctatctatg  tcctagaag  1500
aaaggacag  tgtctgcag  catctgtat  gaaacaata  gagaggaaa  ttcagagat  1560
cgtcagatg  agaagggtg  atttcagcg  gtagtggca  tttttatcc  ctattgtga  1620
gtcaatgga  agccagttg  agatgacta  atttaattg  tccctcctc  tttccagct  1680
ttttgtcag  aagcaagta  ggccatcca  ctgccagag  gctccacag  gacttgagg  1740
atgcagttg  gaggtcctg  ctcggtttg  tatataggg  atatataag  aacatcgaa  1800
ttgtataca  agatttgta  ataaaaaat  tacaaagac  cttcctaaa  taccaactt  1860
atatcatat  tttatacaa  ttaatttaa  aattcattt  aaggaagac  gataatttg  1920
aagactttt  tttttcttg  cttaattca  gaagtatca  tttttgact  agtctccat  1980
tacttcatt  ttaatgatt  ttgtcatcc  tttaaatct  tgccttttt  ttcttgagc  2040
aagctgttt  agtaaacct  ttgaagagt  tttgtgtct  gtgtgcttt  ttgttgtta  2100
taaaacacc  actaaacct  atagtcaag  caaggctct  tgtttctgt  caaagctgt  2160
gttctttct  agtattata  ttgccatgt  tcttaaaat  aagtaaaaa  acttatgag  2220
ttaaaaaaa  gtgagtttg  gagggaaat  gaaaagttt  cagagtatt  ctagtaatt  2280
tttccacat  gaattgtgt  tatgcttta  cttgaatat  aaataaaag  ttattaaaa  2340
ctttaaaaa  aaaaaaaaaa  2360



<210> 7432
<211> 445
<212> PRT
<213> Homo sapiens
<308> AF177339
<400> 7432

Met Cys Pro Gly Ser Val Pro Ala Pro Pro Val Gly Gln Arg Thr Leu 
  1               5                  10                  15
Arg Pro Trp Arg Arg Glu Met Gln Arg Val Leu Ser Ala Gln Met Leu 
             20                  25                  30
Ala Val Thr Gly Pro Arg Asn Ser Gln Arg Arg Thr Ser Arg Cys Ser 
         35                  40                  45
Asp Glu Glu Arg Pro Ser Thr Ser Arg Ala Cys Val Val Asn Gly Pro 
     50                  55                  60
Asp Gly Thr Arg Ser Ala Phe Ser Phe Arg Thr Leu Pro Gln Gly Gly 
 65                  70                  75                  80
Ser Ser Gly Pro Ala His Asp Glu Arg Thr Asn Gly Ser Gly Ser Gly 
                 85                  90                  95
Ala Thr Gly Glu Asp Arg Arg Gly Ser Ser Gln Pro Glu Ser Cys Asp 
             100                105                110
Val Gln Ser Asn Glu Asp Tyr Pro Arg Arg Pro Leu Thr Arg Ala Arg 
         115                120                125
Ser Arg Leu Ser His Val Leu Leu Val Ser Glu Ser Glu Val Ala Lys 
     130                135                140
Thr Lys Pro Arg His Ala Met Lys Arg Lys Arg Thr Ala Asp Lys Ser 
 145                150                155                160
Thr Ser Thr Ser Asp Pro Val Ile Glu Asp Asp His Val Gln Val Leu 
                 165                170                175
Val Leu Lys Ser Lys Asn Leu Val Gly Val Thr Met Thr Asn Cys Gly 
             180                185                190
Ile Thr Asp Leu Val Leu Lys Asp Cys Pro Lys Met Met Phe Ile His 
         195                200                205
Ala Thr Arg Cys Arg Val Leu Lys His Leu Lys Val Glu Asn Ala Pro 
     210                215                220
Ile Val Asn Arg Phe Asp Tyr Ala Gln Cys Lys Lys Leu Asn Met Asp 
 225                230                235                240
Gln Val Leu Asp Gln Ile Leu Arg Met Pro Pro Glu Arg Asn Arg Ile 
                 245                250                255
Ile Tyr Leu Arg Pro Met Gln Gln Val Asp Thr Leu Thr Leu Glu Gln 
             260                265                270
Lys Leu Phe Ser Gly Pro Tyr Pro Tyr His Ile Cys Ile Ile His Glu 
         275                280                285
Phe Ser Asn Pro Pro Asn Val Arg Asn Lys Val Arg Ile Arg Ser Trp 
     290                295                300
Met Asp Thr Ile Ala Asn Ile Asn Gln Glu Leu Ile Lys Tyr Glu Phe 
 305                310                315                320
Phe Pro Glu Ala Thr Arg Ser Glu Glu Asp Leu Lys Lys Tyr Pro Lys 
                 325                330                335
Tyr Pro Trp Gly Arg Glu Ile Tyr Thr Leu Glu Gly Val Val Asp Gly 
             340                345                350
Ala Pro Tyr Ser Met Ile Ser Asp Phe Pro Trp Leu Arg Ser Leu Arg 
         355                360                365
Ala Ala Glu Pro Asn Ser Phe Ala Arg Tyr Asp Phe Glu Asp Asp Glu 
     370                375                380
Glu Ser Thr Ile Tyr Ala Pro Arg Arg Lys Gly Gln Leu Ser Ala Asp 
 385                390                395                400
Ile Cys Met Glu Thr Ile Gly Glu Glu Ile Ser Glu Met Arg Gln Met 
                 405                410                415
Lys Lys Gly Val Phe Gln Arg Val Val Ala Ile Phe Ile His Tyr Cys 
             420                425                430
Asp Val Asn Gly Glu Pro Val Glu Asp Asp Tyr Ile Ter 
         435                440                445



<210> 7433
<211> 413
<212> DNA
<213> Rattus norvegicus
<308> AI639329
<400> 7433

ttaatgaat  catacagct  gctttttaa  aattctgca  agcccagga  atgtatata  60
atttactct  acataaata  atgaagata  aatctatta  atcaattag  aatgtgctt  120
cagattatc  ccaacacag  aaagacaaa  atagaaagc  caagagact  acattttac  180
agtaatata  atcaattct  tttacttgg  ttaaacttt  cagaaaaca  aaaaggact  240
gctcaaatc  caaacccac  actgtcagc  tacctttct  aaagctagc  tccctccta  300
aatcaaaaa  agcatccct  tacaatgca  aagagctcc  gtttacaga  aacaccact  360
agatgccca  cagtagtac  ttttagggg  gagaagtca  agaccacat  aaa  413



<210> 7434
<211> 424
<212> DNA
<213> Rattus norvegicus
<308> AI639336
<400> 7434

ttatttgta  taaattgta  tttcaggaa  attacaagg  ttgacatag  cacagagaa  60
agaacaaac  aaagctagt  taaacaagg  cagttacag  ctgacctct  aaatatgtt  120
gaaaatata  agtagtcac  cttttttaa  aatatgact  aggaaaaat  ttttaattc  180
agtcttctc  atcacttga  atacttgtg  gctaaactc  tacattaag  cagatattg  240
tttttaaat  ctcatttaa  tgatgaaat  tttaaactg  aatcaaagg  gaaagttct  300
gttttaaaa  aaagagaga  cattttatt  ctacaaagg  aactgtaca  aaaatcctt  360
aagccatct  aatgctaac  gctattcaa  gtaaaaaaa  aaaaaaact  caatcagga  420
aaaa  424



<210> 7435
<211> 580
<212> PRT
<213> Rattus norvegicus
<308> NP_061229
<400> 7435

Met Asp Phe Glu Asp Asp Tyr Val His Ser Thr Cys Arg Gly Ala Tyr 
  1               5                  10                  15
Gln Asp Phe Asn Gly Met Asp Arg Asp Tyr Gly Pro Gly Ser Tyr Gly 
             20                  25                  30
Gly Leu Asp Arg Asp Tyr Gly His Gly Ser Tyr Gly Gly Gln Arg Ser 
         35                  40                  45
Met Asp Ser Tyr Leu Asn Gln Ser Tyr Gly Met Asp Asn His Ser Gly 
     50                  55                  60
Gly Gly Gly Gly Ser Arg Phe Gly Pro Tyr Glu Ser Tyr Asp Ser Arg 
 65                  70                  75                  80
Ser Ser Leu Gly Gly Arg Asp Leu Tyr Arg Ser Gly Tyr Gly Phe Asn 
                 85                  90                  95
Glu Pro Glu Gln Thr Arg Phe Gly Gly Ser Tyr Gly Gly Arg Phe Glu 
             100                105                110
Ser Ser Tyr Arg Asn Ser Leu Asp Ser Phe Gly Gly Arg Asn Gln Gly 
         115                120                125
Gly Ser Ser Trp Glu Ala Pro Tyr Ser Arg Ser Lys Leu Arg Pro Gly 
     130                135                140
Phe Met Glu Asp Arg Gly Arg Glu Asn Tyr Ser Ser Tyr Ser Ser Phe 
 145                150                155                160
Ser Ser Pro His Met Lys Pro Ala Pro Val Gly Ser Arg Gly Arg Gly 
                 165                170                175
Thr Pro Ala Tyr Pro Glu Ser Thr Phe Gly Ser Arg Ser Tyr Asp Ala 
             180                185                190
Phe Gly Gly Pro Ser Thr Gly Arg Gly Arg Gly Arg Gly His Met Gly 
         195                200                205
Asp Phe Gly Ser Phe His Arg Pro Gly Ile Ile Val Asp Tyr Gln Asn 
     210                215                220
Lys Pro Ala Asn Val Thr Ile Ala Thr Ala Arg Gly Ile Lys Arg Lys 
 225                230                235                240
Met Met Gln Ile Phe Ile Lys Pro Gly Gly Ala Phe Ile Lys Lys Pro 
                 245                250                255
Lys Leu Ala Lys Pro Met Asp Lys Met Asn Leu Ser Lys Ser Pro Thr 
             260                265                270
Lys Thr Asp Pro Lys Asn Glu Glu Glu Glu Lys Arg Arg Ile Glu Ala 
         275                280                285
Arg Arg Glu Lys Gln Arg Arg Arg Arg Glu Lys Asn Ser Glu Lys Tyr 
     290                295                300
Gly Asp Gly Tyr Arg Met Ala Phe Thr Cys Ser Phe Cys Lys Phe Arg 
 305                310                315                320
Thr Phe Glu Glu Lys Asp Ile Glu Leu His Leu Glu Ser Ser Ser His 
                 325                330                335
Gln Glu Thr Leu Asp His Ile Gln Lys Gln Thr Lys Phe Asp Lys Val 
             340                345                350
Val Met Glu Phe Leu His Glu Cys Met Val Asn Lys Phe Lys Lys Ala 
         355                360                365
Ser Ile Arg Lys Gln Gln Thr Leu Asn His Pro Glu Ala Tyr Lys Ile 
     370                375                380
Ile Glu Lys Asp Ile Met Glu Gly Val Thr Ala Asp Asp His Met Met 
 385                390                395                400
Lys Val Glu Thr Val His Cys Ser Ala Cys Ser Val Tyr Ile Pro Ala 
                 405                410                415
Leu His Ser Ser Val Gln Leu His Leu Lys Ser Pro Asp His Ser Lys 
             420                425                430
Gly Lys Gln Ala Tyr Lys Glu Gln Ile Lys Arg Glu Ser Val Leu Thr 
         435                440                445
Ala Thr Ser Ile Leu Asn Asn Pro Ile Val Lys Ala Arg Tyr Glu Arg 
     450                455                460
Phe Val Lys Gly Glu Asn Pro Phe Glu Ile Gln Asp His Pro Gln Asp 
 465                470                475                480
Gln Gln Ile Glu Gly Asp Glu Glu Asp Glu Glu Lys Ile Asp Glu Pro 
                 485                490                495
Ile Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Glu 
             500                505                510
Glu Ala Gly Ser Val Glu Glu Glu Gly Asp Val Glu Gly Glu Glu Gly 
         515                520                525
Thr Ala Glu Ala Ala Ala Ala Gly Glu Ala Asp Ala Val Gly Glu Ala 
     530                535                540
Glu Gly Ala Gly Glu Ala Glu Glu Ala Glu Glu Glu Glu Glu Glu Glu 
 545                550                555                560
Gly Thr Gln Glu Phe Ala Ala Gln Ala Cys Ala Thr Glu Gln Cys Glu 
                 565                570                575
His Arg Gln Met 
             580



<210> 7436
<211> 811
<212> DNA
<213> Homo sapiens
<308> BG190460
<400> 7436

cgtgccgca  ccggtttta  tgctacaaa  ggaaacatg  tcacaaaga  cctttaagc  60
tatcttaac  caaattact  ttcaatgtc  aatgctgta  aaaaataca  agagcacaa  120
atacttgcc  agtttatat  ttccagggt  agtattaaa  aaattgatg  acacttgaa  180
attcactcc  aagagcagc  tttaagata  aatgattag  atagatata  taacaatac  240
catttgtta  ccttaacac  aataaagta  taaaaatta  gcttaaaaa  tatacaaac  300
atttatcgg  tctaagtct  gtagctata  aaactaaac  aaaatagtt  tgccttcat  360
ttattaaac  aatgttaaa  atttagaaa  tatataaaa  aaattttaa  atgtggaat  420
catgcaaca  gggtgttaa  tcatatttt  agctattaa  tttcttacc  ttttttaca  480
tagaaccga  atgtaaagc  ccttttaaa  ctaatacct  acatttaat  atactaagg  540
cgctcaaca  ggaagttag  ccgatgctt  ttcgctgac  ctaccttaa  tactctact  600
acctactta  ccaactttc  ctcttcccc  ctaccttgg  actagtacc  caattcata  660
tacacttat  catgagccg  ctcagtttg  tgttatacc  ccaatctac  tctataggt  720
acccagaga  ggttttgat  gtataagat  tctccccat  acaaatcgg  cagtcggcc  780
ttctgttgg  actgaattg  atgttatta  t  811



<210> 7437
<211> 500
<212> DNA
<213> Rattus norvegicus
<308> AI639342
<400> 7437

ttaaaaaag  cttttatac  tacattcac  taaacacat  aatacagag  tacattagg  60
atgaactgt  tgctaggtt  tgcaatcta  ttttaaact  catgccttt  caagagctt  120
cttgtcatt  ctgatgagg  acgtgggga  gagactgta  tgggtgtga  tagtattca  180
cttattcat  ttggcgcct  tacaataca  ttttaatat  aagtagaat  ctgcaaaag  240
attggggag  cattttaat  tttacaggg  acgaatcag  agaacaaga  tctatcaaa  300
aggctgtgt  cagtagctg  agcttacaa  acacaccag  aatctgtgc  tggtgtata  360
agagaacca  ggacacaga  ggctttaca  ccaagtgag  acacagcat  aacaaatta  420
aggacaaaa  aattcacat  ttctacatt  aaaaaatta  agatctcac  aatgtcttt  480
aagacacag  anattccaag  500



<210> 7438
<211> 224
<212> DNA
<213> Rattus norvegicus
<308> AI639343
<400> 7438

ttaatgttg  aaagacccg  atgatgttg  ataattgtg  gaaaagtaa  tccgtctca  60
gatcactgt  actgctgtt  ccactagtg  ttcttagga  aacacagtc  acttttcca  120
caaaatgta  gatactata  gctcgatat  agaacagtg  gcccatgaa  gattctatg  180
agctatgca  catagacct  ttgagctgt  aattagcac  attt  224



<210> 7439
<211> 301
<212> DNA
<213> Rattus norvegicus
<308> AI639347
<400> 7439

ttgtctttt  gttctttct  gctttgtga  acgaagaca  gaagttttg  cccaccccc  60
acactgaac  aggaggcgg  ctgaaaaaa  ggagggggg  gggctctaa  aagcttata  120
aaacgtaaa  agagcccgc  cgccatcta  gagggtccc  ccgagaatt  ttcacacca  180
ccacggtgc  ggggggggg  ttcaaaagg  aaaaaaata  cgagagaag  accgagacg  240
agctgaagg  ttttaaaaa  gacgtactg  cccgggggg  tttgttccc  gggcccaat  300
c  301



<210> 7440
<211> 483
<212> DNA
<213> Rattus norvegicus
<308> AI639365
<400> 7440

ttncatttg  atggaacta  atttgtcca  gtggcacac  gagagaagt  tgaaatacg  60
acccacagt  tcatagtgg  tgagccagg  tagcttcag  tttccatca  agatgttca  120
ttgagacgg  cacacccag  ctctctctc  atccactca  cctcagatc  ctcaggagc  180
ctcaggtgg  acagatgaa  gacagaaat  attccactt  attgcggac  ataagcttt  240
ttgggtgga  gttgtctgg  acagccaag  tggaggtca  ttcccacgc  tccacaaag  300
ccacgcgga  accaacaaa  gcagcgcgg  ggaagcggt  catctggag  gtgagccag  360
cactgccat  caccgattt  tagccagtg  tggccagtt  gatgacgac  agagtactg  420
gttcccggt  cagcagggc  ttcacagct  cccgaatcc  tgccagtct  cgagcaaag  480
tgg  483



<210> 7441
<211> 221
<212> DNA
<213> Rattus norvegicus
<308> AI639390
<400> 7441

ttggagaca  ggtctcact  tgtagcctt  tctagtctg  actcacgat  tagatcagg  60
tagctccaa  ctcacagat  cgcctgcct  tatattccc  gtacatgtg  caccccagt  120
ggcaccatc  gttctctga  tacagctct  ccttcattc  atatctgtt  gtgctaagc  180
gcaggaggc  cacagggag  gtcttcaaa  cagggacag  t  221



<210> 7442
<211> 375
<212> DNA
<213> Rattus norvegicus
<308> AI639391
<400> 7442

ttgagctgt  aggaatctt  attccctca  gtgaagcat  cagagaaac  gctctgagt  60
cagaattct  ggctcctct  tccaacacc  ttctgcttc  cacacaccc  ccaccaccg  120
ttttgcttg  gtgtgaacc  atcccccag  cttcccatc  tcttcttaa  tcccatcat  180
ctggggcct  ttctcctta  cattaactg  aggctcaga  acagggagt  caatggctg  240
cagggaacc  actaccatc  tccagggcc  ttaccttca  cggggagca  aaggtacat  300
gcaagtgcc  aggagagcc  acaggagga  gatggcatg  tattctagg  tctgtcaca  360
ggagagctc  ttgaa  375



<210> 7443
<211> 541
<212> DNA
<213> Rattus norvegicus
<308> AI639393
<400> 7443

ttacctcag  acaaataaa  aaagaaaat  tatttacat  agttcatca  tggaaaatc  60
ggcataact  aacgatggg  aaccaggac  gtgtcctag  ctcttgggt  tagacctag  120
tcacagggc  ggcatgggc  ccttacaac  ttctgtaga  acggagaga  gtggcatgg  180
tcttgagca  gttgagcag  agcgtcgac  cccctcagt  aagagaatc  cagcgtccc  240
atcaaggag  tcctgctga  ggcatgggc  tcgtctaac  atgttaagt  cacgtagac  300
tctgtccaa  ttaaacaaa  tccttccat  cagcagtac  taggacaag  agccatggt  360
aggaatggc  acctcttgc  acaaactat  tgacaagag  gatgtggaa  tcatgtgtg  420
caaatatca  gggcctcct  ggtggtttt  ggtccctgt  ggctttgtg  agcagtttg  480
agagaccag  tccaatgtt  attgggatt  ccatgatga  gcactcaga  acaccacac  540
c  541



<210> 7444
<211> 4176
<212> DNA
<213> Homo sapiens
<308> AF021351
<400> 7444

atggtgaag  agcagttcc  ggagacgga  gtggccaag  aaacaagcc  catctgttt  60
ggaatgaag  cacctgagg  gatgcgcca  caggcgcac  tccaagttg  gagtaagaa  120
ctgtacagc  aggacaacc  acatgcccc  ttgctatat  gggtgctcg  ccataggat  180
ggtacgagt  agaaggatc  tccatgtga  acctgtggg  aaaacttgg  tgactgtct  240
ggccactat  ggtatatcg  cctggagtt  ccgtgtttt  atgtagggt  cttcagagc  300
gtcataggc  tcttacaga  gatctgcaa  acctgctgc  acatcatgc  gtcccaaga  360
gagaagaag  agtttctgg  ctatctaaa  aggcccggc  tgacctacc  tcagaagcg  420
ggactgaaa  agaaaatct  tgacaagtg  cggaagaaa  acatctgcc  tcactgtgg  480
gcttttaat  gtaccgtaa  gaagtgtgg  ctgctgaaa  taattcatg  gaaatacaa  540
accaacaaa  aagtggtgg  tcccattgt  tcaaatttc  ttcagtctt  tgaaacagc  600
attgaacat  ataaagaag  ggagcctct  ctgggaagg  cacaggaaa  cttgaatcc  660
ttagtagtt  tgaatttat  taaacgaat  ccagctgaa  atgttcctc  acttctgat  720
aacccagaa  ccggaaagc  gtctgattt  attctcaca  gacttttgg  gcctccttt  780
tgtttcaga  cctccgttg  gagtgattt  aagtctggc  ccaatgaag  tgatctgac  840
atgaaactg  cagaaatca  tttcctaaa  gatgttatt  aaaagcatc  gatctcagg  900
gccaagacc  agatgatca  ggaggactg  gatttcctg  agctgcagt  tgccctcta  960
attaacagt  agctctcgg  cattcccct  aacatggca  ccaagaagt  gaccagagg  1020
ttcgtccaa  gcctgaagg  aaaacaggg  cgatttaga  gaaatctct  aggaaagag  1080
gtggatttt  ctggcagaa  agtcatctc  cccgacccc  acctccgga  tgatgaggt  1140
gctgtgcca  ttcatgtgg  caaaattct  acttttcct  agaaggtaa  caaagcaaa  1200
atcaatttc  tgaggaaac  ggttcaaaa  ggccctgag  ttcacccag  agcaaactt  1260
attcagcag  gacatacgc  gatgaaaag  tttttgaaa  acggaaatc  agaaaagat  1320
gctcaagag  tcaagtatg  tgacatcgt  gagagacac  tcatcgatg  agatgtggt  1380
ctgttcaat  ggcagccct  gctgcacaa  ttgagcatt  tggctcatc  ggccagggt  1440
aagccccac  ggaccttca  atttaatga  tgtgtctgt  caccctata  tgctgactt  1500
gatggtgat  aaatgaacc  tcatcttcc  caaacagaa  aagctaaag  agaggccct  1560
gttctgatg  ggactaaag  aaatcttgt  accccgagg  atggggaac  gctgattgc  1620
gctattcag  attttctaa  aggtgccta  ctcctcact  tcaaggaca  tttctttga  1680
cgagccaag  cttgccaaa  cattgcttc  atactggtt  gcaaggatg  gaaaattaa  1740
gttcgcctc  caccgccta  aatcctaaa  cctgtcacc  tgtggacgg  aaagcagat  1800
ttcagtgtc  tcctcaggc  tagcgatga  aatccagtg  gggccaacc  gcgaaccaa  1860
ggcaagcag  actgtggca  aggggaaga  ctctgtgcc  atgattcct  tgttacaat  1920
cagaacagt  agttgatga  tggcagcat  gacaaagga  ccctagggt  aggatccaa  1980
aacaatatt  tttacattt  gctgcgaga  tggggacag  atgaagctg  agatgccat  2040
tcacggctc  ccaggctgg  tcctgtcta  ctgtctaac  gtggtttct  aattgggat  2100
ggtgatgtc  cacctggcc  aggactgct  aaggccaag  atgagttgc  gaatgccgg  2160
tacaagaaa  gtgatgagt  catcgaagc  ctgaacacg  gcaagctgc  gcagcagcc  2220
ggctgcact  ctgaggaga  cctggaggc  ctgatcctg  aggagctgt  tgtgatccg  2280
gaccacgct  gcagtgcct  cctccggga  ctggacaag  gcaacagcc  cctcaccat  2340
gctctgtgc  gctccaaag  ttccttcat  aacatatca  agatgattg  ctgtgtggg  2400
cagcaggcc  tcagtggct  tcgagtgcc  gacggcttt  aaaacaggt  cttgcctca  2460
tttgaaaaa  actcaaagc  cccagctgc  aaaggcttt  tggctaata  cttttattc  2520
ggtttgaca  caactgagt  tttcttcca  acaatggcc  gccgggaag  tctagtcga  2580
acggctgta  agacagctg  aacgggata  atgcagcga  ggcttgtca  atctcttga  2640
gatctttgc  cccagtatg  tctgacagt  cgaagctct  ctggcgata  tatccagtt  2700
atttatgga  gagatggct  agatcctgc  gctatggag  gaaaagatg  acctttgga  2760
tttaaaagg  ttctggaca  catcaaagc  gtcttcccg  gtcccagtg  gcctgctct  2820
agcaaaaac  agctgatcc  gaccacaga  tccatcatg  agaagagtg  gttcctctg  2880
tgccaggac  gcttcctgc  ggaaataaa  aaattcatt  agggggtct  tgagaagat  2940
aagaaaacc  gagataaat  tggcatcaa  gataacggc  caacagagc  ccgtgtgct  3000
taccagctg  accgcatca  ccccaccca  gtagaaaag  ttctggaga  ctgtaggga  3060
aagtacatg  gggcacaga  ggagccagg  tctgcagtg  gtgctctgt  tgcccagag  3120
attggtgag  caggcaccc  gatgaccct  aagactttc  actttggag  tgtggcctc  3180
atgaacatc  ccctgggcg  gccccggat  aaagagatc  tcaacgctt  caaggccat  3240
agcactcca  ttatcacag  acagctaga  aaggatgac  acgcggatt  tgctcgcct  3300
gtgaaaggg  gaattgaga  aaccctctt  ggagagatt  ccgagtata  tgaagaagt  3360
tttcttcct  atgactgct  tattctcgt  aagctctcc  tggaacgga  taggcttct  3420
agactggaa  tgaacgctg  gacagtgag  tattccatc  gcacatcca  gctccgtgt  3480
aagcccggt  atgtggctg  tcatggtga  gctgtggtg  gtgtcaccc  cagagagaa  3540
agcaagagc  ccatgtact  cgtgctgca  ttcctgaaa  aggatctcc  caaggtggt  3600
gtgcagggc  ttccagagg  gtccagagc  gtcatccac  ttgacgagc  gagtggaaa  3660
gagaagtac  agcttctgg  ggaaggtga  aacctgcgg  cagtcatgg  cacacacgg  3720
gtgaagggc  cccgaacca  ctccaataa  acctatgag  tggagaaaa  tctgggcat  3780
gaggccgcc  ggacaacga  catcaatga  atccagtac  ccatggtgg  gaaccacgg  3840
atgagcatc  acaggaggc  cgtgatgct  ctctccgac  tcatgacct  caagggtga  3900
gtcctgggc  tcactaggt  tggcctggc  aagatgaag  agagtgtgc  gatgctggc  3960
tcctttgag  agacggctg  ccatctctt  gacgctgcc  acttcgggc  gaaggactc  4020
gtgtgtggg  tgtctgagt  catcatcat  ggaatccca  tgaacattg  aaccgggct  4080
ttcaagctg  ttcacaagg  tgacaggga  ccgaaccct  ccaagaggc  cctgatctt  4140
gacacaaat  aattccaca  cccccttgt  acatag  4176



<210> 7445
<211> 1391
<212> PRT
<213> Homo sapiens
<308> O14802
<400> 7445

Met Val Lys Glu Gln Phe Arg Glu Thr Asp Val Ala Lys Lys Thr Ser 
  1               5                  10                  15
His Ile Cys Phe Gly Met Lys Ser Pro Glu Glu Met Arg Gln Gln Ala 
             20                  25                  30
His Ile Gln Val Val Ser Lys Asn Leu Tyr Ser Gln Asp Asn Gln His 
         35                  40                  45
Ala Pro Leu Leu Tyr Gly Val Leu Asp His Arg Met Gly Thr Ser Glu 
     50                  55                  60
Lys Asp Arg Pro Cys Glu Thr Cys Gly Lys Asn Leu Ala Asp Cys Leu 
 65                  70                  75                  80
Gly His Tyr Gly Tyr Ile Asp Leu Glu Leu Pro Cys Phe His Val Gly 
                 85                  90                  95
Tyr Phe Arg Ala Val Ile Gly Ile Leu Gln Met Ile Cys Lys Thr Cys 
             100                105                110
Cys His Ile Met Leu Ser Gln Glu Glu Lys Lys Gln Phe Leu Asp Tyr 
         115                120                125
Leu Lys Arg Pro Gly Leu Thr Tyr Leu Gln Lys Arg Gly Leu Lys Lys 
     130                135                140
Lys Ile Ser Asp Lys Cys Arg Lys Lys Asn Ile Cys His His Cys Gly 
 145                150                155                160
Ala Phe Asn Gly Thr Val Lys Lys Cys Gly Leu Leu Lys Ile Ile His 
                 165                170                175
Glu Lys Tyr Lys Thr Asn Lys Lys Val Val Asp Pro Ile Val Ser Asn 
             180                185                190
Phe Leu Gln Ser Phe Glu Thr Ala Ile Glu His Asn Lys Glu Val Glu 
         195                200                205
Pro Leu Leu Gly Arg Ala Gln Glu Asn Leu Asn Pro Leu Val Val Leu 
     210                215                220
Asn Leu Phe Lys Arg Ile Pro Ala Glu Asp Val Pro Leu Leu Leu Met 
 225                230                235                240
Asn Pro Glu Ala Gly Lys Pro Ser Asp Leu Ile Leu Thr Arg Leu Leu 
                 245                250                255
Val Pro Pro Leu Cys Phe Arg Pro Ser Val Val Ser Asp Leu Lys Ser 
             260                265                270
Gly Thr Asn Glu Asp Asp Leu Thr Met Lys Leu Thr Glu Ile Ile Phe 
         275                280                285
Leu Asn Asp Val Ile Lys Lys His Arg Ile Ser Gly Ala Lys Thr Gln 
     290                295                300
Met Ile Met Glu Asp Trp Asp Phe Leu Gln Leu Gln Cys Ala Leu Tyr 
 305                310                315                320
Ile Asn Ser Glu Leu Ser Gly Ile Pro Leu Asn Met Ala Pro Lys Lys 
                 325                330                335
Trp Thr Arg Gly Phe Val Gln Arg Leu Lys Gly Lys Gln Gly Arg Phe 
             340                345                350
Arg Gly Asn Leu Ser Gly Lys Arg Val Asp Phe Ser Gly Arg Thr Val 
         355                360                365
Ile Ser Pro Asp Pro Asn Leu Arg Ile Asp Glu Val Ala Val Pro Val 
     370                375                380
His Val Ala Lys Ile Leu Thr Phe Pro Glu Lys Val Asn Lys Ala Asn 
 385                390                395                400
Ile Asn Phe Leu Arg Lys Leu Val Gln Asn Gly Pro Glu Val His Pro 
                 405                410                415
Gly Ala Asn Phe Ile Gln Gln Arg His Thr Gln Met Lys Arg Phe Leu 
             420                425                430
Lys Tyr Gly Asn Arg Glu Lys Met Ala Gln Glu Leu Lys Tyr Gly Asp 
         435                440                445
Ile Val Glu Arg His Leu Ile Asp Gly Asp Val Val Leu Phe Asn Arg 
     450                455                460
Gln Pro Ser Leu His Lys Leu Ser Ile Met Ala His Leu Ala Arg Val 
 465                470                475                480
Lys Pro His Arg Thr Phe Arg Phe Asn Glu Cys Val Cys Thr Pro Tyr 
                 485                490                495
Asn Ala Asp Phe Asp Gly Asp Glu Met Asn Leu His Leu Pro Gln Thr 
             500                505                510
Glu Glu Ala Lys Ala Glu Ala Leu Val Leu Met Gly Thr Lys Ala Asn 
         515                520                525
Leu Val Thr Pro Arg Asn Gly Glu Pro Leu Ile Ala Ala Ile Gln Asp 
     530                535                540
Phe Leu Thr Gly Ala Tyr Leu Leu Thr Leu Lys Asp Thr Phe Phe Asp 
 545                550                555                560
Arg Ala Lys Ala Cys Gln Ile Ile Ala Ser Ile Leu Val Gly Lys Asp 
                 565                570                575
Glu Lys Ile Lys Val Arg Leu Pro Pro Pro Thr Ile Leu Lys Pro Val 
             580                585                590
Thr Leu Trp Thr Gly Lys Gln Ile Phe Ser Val Ile Leu Arg Pro Ser 
         595                600                605
Asp Asp Asn Pro Val Arg Ala Asn Leu Arg Thr Lys Gly Lys Gln Tyr 
     610                615                620
Cys Gly Lys Gly Glu Asp Leu Cys Ala Asn Asp Ser Tyr Val Thr Ile 
 625                630                635                640
Gln Asn Ser Glu Leu Met Ser Gly Ser Met Asp Lys Gly Thr Leu Gly 
                 645                650                655
Ser Gly Ser Lys Asn Asn Ile Phe Tyr Ile Leu Leu Arg Asp Trp Gly 
             660                665                670
Gln Asn Glu Ala Ala Asp Ala Met Ser Arg Leu Ala Arg Leu Ala Pro 
         675                680                685
Val Tyr Leu Ser Asn Arg Gly Phe Ser Ile Gly Ile Gly Asp Val Thr 
     690                695                700
Pro Gly Gln Gly Leu Leu Lys Ala Lys Tyr Glu Leu Leu Asn Ala Gly 
 705                710                715                720
Tyr Lys Lys Cys Asp Glu Tyr Ile Glu Ala Leu Asn Thr Gly Lys Leu 
                 725                730                735
Gln Gln Gln Pro Gly Cys Thr Ala Glu Glu Thr Leu Glu Ala Leu Ile 
             740                745                750
Leu Lys Glu Leu Ser Val Ile Arg Asp His Ala Gly Ser Ala Cys Leu 
         755                760                765
Arg Glu Leu Asp Lys Ser Asn Ser Pro Leu Thr Met Ala Leu Cys Gly 
     770                775                780
Ser Lys Gly Ser Phe Ile Asn Ile Ser Gln Met Ile Ala Cys Val Gly 
 785                790                795                800
Gln Gln Ala Ile Ser Gly Ser Arg Val Pro Asp Gly Phe Glu Asn Arg 
                 805                810                815
Ser Leu Pro His Phe Glu Lys His Ser Lys Leu Pro Ala Ala Lys Gly 
             820                825                830
Phe Val Ala Asn Ser Phe Tyr Ser Gly Leu Thr Pro Thr Glu Phe Phe 
         835                840                845
Phe His Thr Met Ala Gly Arg Glu Gly Leu Val Asp Thr Ala Val Lys 
     850                855                860
Thr Ala Glu Thr Gly Tyr Met Gln Arg Arg Leu Val Lys Ser Leu Glu 
 865                870                875                880
Asp Leu Cys Ser Gln Tyr Asp Leu Thr Val Arg Ser Ser Thr Gly Asp 
                 885                890                895
Ile Ile Gln Phe Ile Tyr Gly Gly Asp Gly Leu Asp Pro Ala Ala Met 
             900                905                910
Glu Gly Lys Asp Glu Pro Leu Glu Phe Lys Arg Val Leu Asp Asn Ile 
         915                920                925
Lys Ala Val Phe Pro Cys Pro Ser Glu Pro Ala Leu Ser Lys Asn Glu 
     930                935                940
Leu Ile Leu Thr Thr Glu Ser Ile Met Lys Lys Ser Glu Phe Leu Cys 
 945                950                955                960
Cys Gln Asp Ser Phe Leu Gln Glu Ile Lys Lys Phe Ile Lys Gly Val 
                 965                970                975
Ser Glu Lys Ile Lys Lys Thr Arg Asp Lys Tyr Gly Ile Asn Asp Asn 
             980                985                990
Gly Thr Thr Glu Pro Arg Val Leu Tyr Gln Leu Asp Arg Ile Thr Pro 
         995                1000                1005
Thr Gln Val Glu Lys Phe Leu Glu Thr Cys Arg Asp Lys Tyr Met Arg 
     1010                1015                1020
Ala Gln Met Glu Pro Gly Ser Ala Val Gly Ala Leu Cys Ala Gln Ser 
 1025                1030                1035                1040
Ile Gly Glu Pro Gly Thr Gln Met Thr Leu Lys Thr Phe His Phe Gly 
                 1045                1050                1055
Gly Val Ala Ser Met Asn Ile Thr Leu Gly Val Pro Arg Ile Lys Glu 
             1060                1065                1070
Ile Ile Asn Ala Ser Lys Ala Ile Ser Thr Pro Ile Ile Thr Ala Gln 
         1075                1080                1085
Leu Asp Lys Asp Asp Asp Ala Asp Tyr Ala Arg Leu Val Lys Gly Arg 
     1090                1095                1100
Ile Glu Lys Thr Leu Leu Gly Glu Ile Ser Glu Tyr Ile Glu Glu Val 
 1105                1110                1115                1120
Phe Leu Pro Asp Asp Cys Phe Ile Leu Val Lys Leu Ser Leu Glu Arg 
                 1125                1130                1135
Ile Arg Leu Leu Arg Leu Glu Val Asn Ala Glu Thr Val Arg Tyr Ser 
             1140                1145                1150
Ile Cys Thr Ser Lys Leu Arg Val Lys Pro Gly Asp Val Ala Val His 
         1155                1160                1165
Gly Glu Ala Val Val Cys Val Thr Pro Arg Glu Asn Ser Lys Ser Ser 
     1170                1175                1180
Met Tyr Tyr Val Leu Gln Phe Leu Lys Glu Asp Leu Pro Lys Val Val 
 1185                1190                1195                1200
Val Gln Gly Ile Pro Glu Val Ser Arg Ala Val Ile His Ile Asp Glu 
                 1205                1210                1215
Gln Ser Gly Lys Glu Lys Tyr Lys Leu Leu Val Glu Gly Asp Asn Leu 
             1220                1225                1230
Arg Ala Val Met Ala Thr His Gly Val Lys Gly Thr Arg Thr Thr Ser 
         1235                1240                1245
Asn Asn Thr Tyr Glu Val Glu Lys Thr Leu Gly Ile Glu Ala Ala Arg 
     1250                1255                1260
Thr Thr Ile Ile Asn Glu Ile Gln Tyr Thr Met Val Val Asn His Gly 
 1265                1270                1275                1280
Met Ser Ile Asp Arg Arg His Val Met Leu Leu Ser Asp Leu Met Thr 
                 1285                1290                1295
Tyr Lys Gly Glu Val Leu Gly Ile Thr Arg Phe Gly Leu Ala Lys Met 
             1300                1305                1310
Lys Glu Ser Val Leu Met Leu Ala Ser Phe Glu Lys Thr Ala Asp His 
         1315                1320                1325
Leu Phe Asp Ala Ala Tyr Phe Gly Gln Lys Asp Ser Val Cys Gly Val 
     1330                1335                1340
Ser Glu Cys Ile Ile Met Gly Ile Pro Met Asn Ile Gly Thr Gly Leu 
 1345                1350                1355                1360
Phe Lys Leu Leu His Lys Ala Asp Arg Asp Pro Asn Pro Pro Lys Arg 
                 1365                1370                1375
Pro Leu Ile Phe Asp Thr Asn Glu Phe His Ile Pro Leu Val Thr 
             1380                1385                1390



<210> 7446
<211> 522
<212> DNA
<213> Rattus norvegicus
<308> AI639410
<400> 7446

ttcaaaaag  ggatgaaac  ttattattg  cttcaatgt  cagtacaat  attagtcaa  60
tatcaagta  ttgaaatag  ataatagaa  cacatattt  aatgcaaag  aaagagata  120
tgtgtaatt  tataagcaa  ttatcaaat  aaaagacaa  attggctga  tgttgactt  180
tcaaatata  tccactcaa  acccaagaa  atgttttat  ctataaaat  cttctatat  240
ttttgagga  ttttctaat  taacaaaat  tatatgaaa  atgaaattt  aaaattgtt  300
gaaaacact  aatatgagc  caatgtaga  atctgaaga  agactgttc  tttggcaga  360
aataaatag  tacaaacat  ttaaaataa  tacagttca  taggatcat  gaaaaaata  420
atctttaca  ttcgtatta  tactgaaat  agatcaata  agatttact  tcattttta  480
gctatcaat  actctgcaa  acaaattta  gaatggaaa  aa  522



<210> 7447
<211> 522
<212> DNA
<213> Rattus norvegicus
<308> AI639410
<400> 7447

ttcaaaaag  ggatgaaac  ttattattg  cttcaatgt  cagtacaat  attagtcaa  60
tatcaagta  ttgaaatag  ataatagaa  cacatattt  aatgcaaag  aaagagata  120
tgtgtaatt  tataagcaa  ttatcaaat  aaaagacaa  attggctga  tgttgactt  180
tcaaatata  tccactcaa  acccaagaa  atgttttat  ctataaaat  cttctatat  240
ttttgagga  ttttctaat  taacaaaat  tatatgaaa  atgaaattt  aaaattgtt  300
gaaaacact  aatatgagc  caatgtaga  atctgaaga  agactgttc  tttggcaga  360
aataaatag  tacaaacat  ttaaaataa  tacagttca  taggatcat  gaaaaaata  420
atctttaca  ttcgtatta  tactgaaat  agatcaata  agatttact  tcattttta  480
gctatcaat  actctgcaa  acaaattta  gaatggaaa  aa  522



<210> 7448
<211> 454
<212> DNA
<213> Rattus norvegicus
<308> AI639425
<400> 7448

ttgagttct  tagacttta  caaatgtat  ttccatttg  tagttttta  agtagcttc  60
actgatgtt  cacacacca  agctctgta  acttatgca  ttagcctgt  tcagaaagc  120
aataaaccg  aggtaacat  tcccccaga  ctcctcggg  aacataatt  ggctgtaca  180
acacatcac  aattcaaca  cacacggtg  acccgaaac  ttttctatg  acctcaaaa  240
ttctttgga  gtaatcact  aacattggt  tcgagcaaa  atcagattt  gagcctcca  300
ttttgtgct  tgttgtgtc  gcgacaaga  cgccatcca  gtcctttaa  caacgaaga  360
atgcgcaga  ccagttcag  aatcgtcaa  tttgacgac  aaacagaag  atggctgcc  420
actcccttc  tcagcacga  ccctgttac  ttct  454



<210> 7449
<211> 693
<212> DNA
<213> Homo sapiens
<308> BE792880
<400> 7449

gccccggcg  ccgggtgag  tcctcaagg  ctcggaggg  cgagggcag  caccggcgg  60
cgggcggag  gcttactgc  ctctctctt  caggccgtc  gggcgctga  gctcatagg  120
tgggcttcc  gaagccttc  tccgttgcc  ggttcccgg  atcgggccc  ccctgccgc  180
gaggaagag  acgaccctg  ccgccccat  gagttttcc  ccagcaaag  caaccctca  240
cgctggtcg  tgggccata  catgggaaa  ggacatcag  ggccctggt  gaaggtgct  300
cccctcagc  gcttcctcg  ggcgctgat  atctggtgc  acctgaggg  ggagagcga  360
gcggaccag  ggttgagac  ggtgtgggg  gaggtgcca  agcccagtg  tcgttctga  420
gagcctgag  ctccagctg  ctacagagc  agaacttga  ggggtgccc  ctggggctg  480
caggaaggg  gccgacagc  gcccttcgg  tttgatgtc  cgtttgccc  tgactgtcc  540
ggctatgcg  gcgtcctca  cactgaagg  cttggctgg  ggatggggc  cttggctat  600
ctgattcgc  tgaaggcgg  gcagaatct  agcagatcg  aaactgctc  tcgcctggt  660
ttgatgtcc  aggattcca  cggcaagac  tct  693



<210> 7450
<211> 454
<212> DNA
<213> Rattus norvegicus
<308> AI639425
<400> 7450

ttgagttct  tagacttta  caaatgtat  ttccatttg  tagttttta  agtagcttc  60
actgatgtt  cacacacca  agctctgta  acttatgca  ttagcctgt  tcagaaagc  120
aataaaccg  aggtaacat  tcccccaga  ctcctcggg  aacataatt  ggctgtaca  180
acacatcac  aattcaaca  cacacggtg  acccgaaac  ttttctatg  acctcaaaa  240
ttctttgga  gtaatcact  aacattggt  tcgagcaaa  atcagattt  gagcctcca  300
ttttgtgct  tgttgtgtc  gcgacaaga  cgccatcca  gtcctttaa  caacgaaga  360
atgcgcaga  ccagttcag  aatcgtcaa  tttgacgac  aaacagaag  atggctgcc  420
actcccttc  tcagcacga  ccctgttac  ttct  454



<210> 7451
<211> 693
<212> DNA
<213> Homo sapiens
<308> BE792880
<400> 7451

gccccggcg  ccgggtgag  tcctcaagg  ctcggaggg  cgagggcag  caccggcgg  60
cgggcggag  gcttactgc  ctctctctt  caggccgtc  gggcgctga  gctcatagg  120
tgggcttcc  gaagccttc  tccgttgcc  ggttcccgg  atcgggccc  ccctgccgc  180
gaggaagag  acgaccctg  ccgccccat  gagttttcc  ccagcaaag  caaccctca  240
cgctggtcg  tgggccata  catgggaaa  ggacatcag  ggccctggt  gaaggtgct  300
cccctcagc  gcttcctcg  ggcgctgat  atctggtgc  acctgaggg  ggagagcga  360
gcggaccag  ggttgagac  ggtgtgggg  gaggtgcca  agcccagtg  tcgttctga  420
gagcctgag  ctccagctg  ctacagagc  agaacttga  ggggtgccc  ctggggctg  480
caggaaggg  gccgacagc  gcccttcgg  tttgatgtc  cgtttgccc  tgactgtcc  540
ggctatgcg  gcgtcctca  cactgaagg  cttggctgg  ggatggggc  cttggctat  600
ctgattcgc  tgaaggcgg  gcagaatct  agcagatcg  aaactgctc  tcgcctggt  660
ttgatgtcc  aggattcca  cggcaagac  tct  693



<210> 7452
<211> 369
<212> DNA
<213> Rattus norvegicus
<308> AI639427
<400> 7452

ttaaatttt  tagtgaaaa  attatatta  aacatgctt  tccaaatca  attattaaa  60
ttaatattt  agtttaaac  aagtcttta  attctacat  cataatttt  actggctaa  120
ctacacatt  aacacctcg  taacattct  ctcacagct  agactttta  acaccaaca  180
tctattaat  gagctactg  aggacagat  cgaattaga  gtcttaggt  attttttaa  240
ctcgctttc  gagcaccga  catcaacaa  tatttctgc  ttgtattca  aaacactga  300
acaatttgt  catttatat  aaaacagat  caatgttta  aaatgaacg  gcattaaag  360
agtttaact  369



<210> 7453
<211> 369
<212> DNA
<213> Rattus norvegicus
<308> AI639427
<400> 7453

ttaaatttt  tagtgaaaa  attatatta  aacatgctt  tccaaatca  attattaaa  60
ttaatattt  agtttaaac  aagtcttta  attctacat  cataatttt  actggctaa  120
ctacacatt  aacacctcg  taacattct  ctcacagct  agactttta  acaccaaca  180
tctattaat  gagctactg  aggacagat  cgaattaga  gtcttaggt  attttttaa  240
ctcgctttc  gagcaccga  catcaacaa  tatttctgc  ttgtattca  aaacactga  300
acaatttgt  catttatat  aaaacagat  caatgttta  aaatgaacg  gcattaaag  360
agtttaact  369



<210> 7454
<211> 422
<212> DNA
<213> Rattus norvegicus
<308> AI639434
<400> 7454

ttaggattt  caaatacag  ttattttac  gaaattcaa  attataaac  gcaggcacc  60
ccgacgagg  atgagaagc  gctggcaca  attgatggc  ccctgtcaa  catcgagtt  120
cagcgggag  ccctataga  tgccaacac  aacacggag  tgctcaaga  catgggcta  180
gccgccaag  ccatgaagg  tgcccacga  aacatggac  ttgataaag  ggatgagtt  240
atgcaggac  ttgctgacc  gcaagaact  gcagaagag  tttccacag  tatctccaa  300
cctgtgggc  ttggagaag  gtttgacga  gatgagctc  tggcagagc  ggaggaact  360
gaacaagag  agctagaca  gaatttgtt  gagatcaga  ggcccgaaa  agtccctct  420
cc  422



<210> 7455
<211> 258
<212> DNA
<213> Homo sapiens
<308> AW603521
<400> 7455

gtggccggt  ccttcaaca  ctcaggctc  ttccaacat  tcatggctc  ttccaacat  60
tcattcctc  ttccaacat  tcatccctc  ttccaacat  tcattgctg  tgaaatctc  120
tctgcaagt  cttgctggt  agcaatgtc  tgcattaac  catcaactt  atcgatgtc  180
atgttgtca  gggccgcct  catggcctt  gcggcatag  ccatgttct  gagcacctc  240
ggatgagat  ttggaagg  258



<210> 7456
<211> 445
<212> DNA
<213> Rattus norvegicus
<308> AI639438
<400> 7456

ttgaacatc  tgataattt  ttatttttt  gtatattgg  ggttgaaat  ataggagta  60
atacacata  aaaatagaa  taagactct  gctgaaaat  tgtaaccta  acaagtgtt  120
acagccaga  aacagtcca  ttatctgat  ctgagagaa  gacactatg  gtttcaaaa  180
tagctcaca  gccaagtat  cactggagt  aaacattac  tctttctca  acttacata  240
aaatacaaa  tagtaaccc  gaagaaaaa  ctgtaagaa  cgagatatt  tttgtcgag  300
aagggggca  ttgaggata  ttgcaatgc  tttccttcc  gtggcttgg  tggacatga  360
tgttatgcc  tcagcaccg  gtccatgct  tgtctcaca  cagaagcct  tgcctggtt  420
tgaaaatac  ttcatggct  ttcac  445



<210> 7457
<211> 1002
<212> PRT
<213> Rattus norvegicus
<308> AAK84214
<400> 7457

Met Val Arg Leu Tyr Asn Leu His Pro Phe Gly Ser Gln Gln Val Val 
  1               5                  10                  15
Pro Cys Gln Trp Glu Pro Glu Gln Val Cys Cys Gly Gly Ser Asp Ala 
             20                  25                  30
Leu Phe Val Ala Ala Gly Cys Lys Val Glu Ala Phe Ala Val Gln Gly 
         35                  40                  45
Glu Glu Leu Cys Arg Gln Arg Cys Ala Phe Ser Thr Leu Gly Arg Val 
     50                  55                  60
Leu Arg Met Ala Tyr Ser Glu Ala Gly Asp Tyr Leu Val Ala Ile Glu 
 65                  70                  75                  80
Glu Lys Asn Lys Thr Ile Phe Leu Arg Ala Tyr Val Asn Trp Arg Ser 
                 85                  90                  95
Lys Arg Ser Asp Asn Ser Arg Val Cys Ile Arg Met Val Gly His Asn 
             100                105                110
Val Glu Ala Ser Phe Cys Glu Ser Phe Arg Asp Gln Met Ser Ile Ile 
         115                120                125
Glu Met Pro Met Ser Glu Ala Pro Leu Cys Phe Ser Cys Cys Pro Val 
     130                135                140
Lys Gly Asp Leu Leu Val Gly Cys Thr Asn Lys Leu Val Leu Phe Thr 
 145                150                155                160
Leu Lys Tyr Asp Ile Ile Asn Glu Glu Phe Ser Ile Leu Asn Phe Glu 
                 165                170                175
Arg Ser Leu Ile Ile His Ile Asp Asn Ile Thr Pro Val Glu Ile Ser 
             180                185                190
Phe Cys Val Gly Tyr Val Ala Val Met Ser Asp Leu Glu Val Leu Leu 
         195                200                205
Leu Lys Leu Glu Ser Asp Pro Ile His Gly Glu Ser Val Asp His His 
     210                215                220
Pro Gln Glu Thr Ser Asn Pro Leu Lys Glu Ala Glu Gly Val Ser Asn 
 225                230                235                240
Glu Thr Ser Gln Leu Glu Ser Glu Asp Phe Val Ile Cys Leu Lys Pro 
                 245                250                255
Met Glu Leu Ile Gly Glu Lys Cys Glu Gln Ser Gly Ile Ser Val Lys 
             260                265                270
Leu Glu Ser Thr Gly Leu Glu Asp Glu Lys Val Lys Tyr Leu Arg Val 
         275                280                285
Arg His Leu Leu Tyr Arg Arg Phe Ala Pro Asp Ile Ser Ser Tyr Val 
     290                295                300
Leu Ser Asp Asn Ile Lys Leu His Ser Leu Gln Leu Leu Pro Ile His 
 305                310                315                320
Gln Ser Gly Phe His Pro Asp Glu Asn Asp Leu Ser Pro Lys Lys Glu 
                 325                330                335
Met Pro Asn Leu Phe Cys Phe Phe Ser Leu Pro His Val Gly Tyr Leu 
             340                345                350
Tyr Met Val Val Lys Ser Val Glu Leu Met Ser Val Tyr Trp Tyr Pro 
         355                360                365
Glu Lys Ser Gln Gln Ala Val Leu Thr Pro Gln Phe Leu His Val Ile 
     370                375                380
Thr Ser Gln Ser Leu Gln Cys Phe Thr Val Arg Cys Ser Ala Ala Val 
 385                390                395                400
Ala His Glu Glu Asp Leu Tyr Met Asp Thr Thr Leu Lys Ala Cys Pro 
                 405                410                415
Pro Val Ser Met Asp Val Cys Ala Leu Arg Ile Gln Leu Phe Ile Gly 
             420                425                430
Leu Lys Ala Ile Cys His Phe Lys Asn His Ile Ile Leu Leu Thr Lys 
         435                440                445
Ala Glu Pro Glu Ala Ile Pro Glu Arg Arg Glu Ser Pro Lys Lys Leu 
     450                455                460
Ile Ser Arg Lys Asp Ala Ser Val Arg Ser Gly Thr Pro His Val Ala 
 465                470                475                480
Glu Ala Ala Trp Asn Leu Tyr Leu Val Asn Thr Thr Ala Pro Val Gln 
                 485                490                495
Leu Tyr Lys Glu Met Val Asp Tyr Ser Asn Ser Tyr Lys Thr Val Lys 
             500                505                510
Thr Glu Ser Cys Leu His Leu Leu Ser Glu Ala His Leu Leu Val Arg 
         515                520                525
Ala Ala Leu Met Asp Gly Ser Gln Leu Glu Pro Ala Glu Lys Ala Glu 
     530                535                540
Leu Leu Glu Ala Phe Lys Glu Ser Cys Gly His Leu Gly Asp Cys Tyr 
 545                550                555                560
Ser Arg Leu Thr Thr Glu Gln Ser His Leu Ala Leu Pro Tyr Tyr Lys 
                 565                570                575
Met Ser Gly Leu Ser Leu Ala Glu Val Leu Ala Arg Val Asp Trp Thr 
             580                585                590
Glu Glu Ser Glu Ser Gln Lys Tyr Glu Arg Gly Leu Val Phe Tyr Ile 
         595                600                605
Asn His Ser Leu Tyr Glu Asn Leu Asp Glu Glu Leu Ser Lys Glu Leu 
     610                615                620
Ala Ala Lys Val Ala Gln Ile Phe His Met Ala Glu Pro Lys Gln Leu 
 625                630                635                640
Pro His Val Leu Ser Ser Pro Ser Met Lys Asn Ile Asp Pro Leu Thr 
                 645                650                655
Ala Leu His Tyr Leu Arg Lys Leu Asp Ser Cys Gly Val Ser Pro Val 
             660                665                670
Leu Val Thr Leu Thr Lys Ala Ala Val Ala Leu Lys Met Gly Asp Leu 
         675                680                685
Asp Met Tyr Arg Asn Glu Met Lys Ser His Ser Glu Met Lys Leu Val 
     690                695                700
Tyr Gly Phe Ile Leu Glu Pro Arg Leu Leu Ile Gln Gln Trp Lys Gly 
 705                710                715                720
Gln Ile Val Pro Thr Glu Leu Ala Ile Asp Leu Lys Glu Thr Gln Pro 
                 725                730                735
Gly Leu Leu Val Ala Ser Val Leu Gly Leu Gln Lys Asn Asp Lys Ile 
             740                745                750
Gly Ile Val Glu Thr Asp Ser Phe Phe Lys Val Leu Cys Gly Lys Asp 
         755                760                765
Glu Asp Ala Val Pro Gln Leu Leu Ile Asp Phe Trp Glu Ala Gln Leu 
     770                775                780
Val Ala Cys Leu Pro Asn Val Val Leu Glu Glu Leu Phe Phe Lys Leu 
 785                790                795                800
Ile Ser Gln Tyr Val Trp Arg Leu Ser Glu Arg Arg Cys Pro Asp Thr 
                 805                810                815
Val Pro Leu Arg Thr Ala Glu Asp Leu Ile Asn Ala Cys Ser His Tyr 
             820                825                830
Gly Leu Val Asn Pro Trp Val His Val Leu Thr Thr Ser Asp Ser Leu 
         835                840                845
Ala Asp Lys Asn Tyr Thr Asp Asp Leu Leu Lys Leu Gln Ser Leu Ile 
     850                855                860
Cys Ser Pro Ser Leu Asp Val Ala Ser Ile Ile Pro Phe Leu Glu Pro 
 865                870                875                880
Leu Ser Glu Asp Thr Val Ala Gly Leu Ser Ala His Ala Leu Cys His 
                 885                890                895
Thr Arg Leu Gln Glu Tyr Glu Gln Cys Ile Asp Thr Leu Leu Glu Arg 
             900                905                910
Cys Pro Glu Ala Val Ile Ala Tyr Ala Asn Gln Glu Leu Lys Glu Asp 
         915                920                925
His Trp Ile Leu Trp Trp Lys Lys Leu Leu Pro Glu Leu Cys Gln Arg 
     930                935                940
Val Lys Ser Gly Gly Glu Arg Ser His Leu His Leu Ser Leu Leu Lys 
 945                950                955                960
Glu Thr Leu Ser Val Ile Ala Val Gly Leu Asp Leu Arg Asp Phe Leu 
                 965                970                975
Asn Val Leu Pro Glu Asp Gly Ala Ala Ala Phe Phe Leu Pro Tyr Leu 
             980                985                990
Leu Phe Cys Ser Arg Lys Lys Ser Leu Thr 
         995                1000



<210> 7458
<211> 3912
<212> DNA
<213> Homo sapiens
<308> AY033141
<400> 7458

ccgcgggcg  ggccggctg  cgttcacgt  acccggcgt  attggctcg  tcgcggaag  60
agtcctaca  tcgcggtca  cgcggggtc  ccgggcgcc  tgcagggcg  gcaggctgt  120
ccatcccgc  ggacgtcgg  atggtgcag  tgtacaacc  gcacccgtt  gggtcgcag  180
aggtggtgc  ctgcaagct  gagccggac  ggttctgtg  cggggggcg  gacgcgctt  240
tcgtggcgg  gggctgcaa  gtggaggcg  tcgcggtgg  cggccagga  ctgtgccag  300
cgcggtgcg  cttctccac  ctgggccgg  tgttgcgcc  ggcctacag  gaggctgga  360
attatttgg  agcaattga  gagaaaaac  aagctacat  tctacgtgc  tatgtgaac  420
ggagaaata  aaggactga  aactctcgt  tgtgtatcc  aatgattgg  cataatgtg  480
agggaccat  cagcaaagc  ttcagagac  agatgtaca  tattgaaat  ccgctttcg  540
aggccccct  gtgcatttc  tgttgccct  tgaaaggag  ccttctcgt  ggctgcaca  600
ataaattag  cttatttag  ttgaagtac  agatcatta  tgaggaatt  tcactattg  660
actttgaac  ttctttaat  atacacata  ataatatca  tcctgttga  gtttctttt  720
gtgttggat  tgttgctgt  atgtcagac  tagaagtct  aatcgtaaa  ctggagtca  780
gccctaaaa  tggagagag  gttcaccac  atccacata  gaccaacaa  cgaataaga  840
ggacagaag  aggcatcag  aatgaaatt  cacagcttg  gtcagatga  tttgtcatc  900
gccagaagc  cctggaact  cttggtgaa  aaagtgaac  gtctggatt  tctgttaca  960
tggagtcta  gggattagc  gatgaaaaa  gaaaatatt  ccactttca  cacctgctc  1020
atagacgtt  tgctcctga  atttcgtcc  atgtcttgt  tgatgacat  aagctacat  1080
ccctccagc  gctacccat  taccagacc  gttctctta  atctgatgg  aaaaatttg  1140
ctcaggaaa  agaattgct  agtctcttt  gctttttct  cttacctca  gtgggctat  1200
tctacatgg  tgtcaaatc  gttgaattg  tgtcagtct  ccagtatcc  gaaaagtct  1260
agcaggcag  actcacgcc  caatttttg  acgtcatta  aagtaacaa  ctgcagtgt  1320
tcactgtgc  gtgcagtgc  gcggcagct  gtgaggagg  cccgtacat  gacaccacc  1380
tgaaggctt  cccacctgt  agtatggat  tctgtgctt  aagaataca  cttttcata  1440
gcttgaaag  catctgtca  tttaaaaac  acatcatac  tttgactaa  gcagaacct  1500
aagccattc  agagagaag  cagtcaccc  agaggcttc  ttcgagaaa  gataccagt  1560
ttaaaatca  aatacctcc  gtagctgag  ctgggtgga  tttgtatat  gtgaatacg  1620
tctcaccag  gcagctgta  aaagagatg  tagactata  caataccta  aagactgtc  1680
aaacccaga  ctgcattca  cttctcagt  aggctcatc  gttagtgcg  gctgccctg  1740
tggatgcca  tcagctgga  cctggagag  aggcagagc  tttggaagc  tttaaggaa  1800
gctgtgggc  ccttgggga  tgttacagc  ggcttgact  ccagcattc  catctcacc  1860
tgccatact  taagatgtc  ggtttgtct  tggctgaag  tctggcccg  acggactgg  1920
cagtagagg  tggattaca  aaatacgag  gaggattaa  cttttacat  aatcattca  1980
tttatgaaa  cctggatga  gaattaaat  aagaattag  agcaaaagt  gttcagatg  2040
tttatgtgg  tgagccaaa  caagtgccc  atattctct  tagtccttc  atgaagaat  2100
ttaatcctt  aactgccat  agctatcta  ggaagctgg  tacttctgg  ttttcatcg  2160
tcttagtga  attgaccaa  gcagcagtg  ctctgaaaa  gggagatct  gacatgcac  2220
gaaatgaaa  gaaaagcca  tcagagatg  agttggtat  tggcttcat  ctggaacct  2280
ggctgttga  tcaacagag  aagggacag  ttgttccaa  cgagcttgc  cttcacttg  2340
aggaaactc  gcctggatt  cttgtggct  cagttctgg  cttgcagaa  aacaacaaa  2400
ttggaattg  agaagcaga  tcctttttt  aggtgcttt  tgctaagga  gaagataca  2460
ttcctcagc  cttggtaga  ttttgggaa  ctcagctag  ggcatgtct  ccagatgtg  2520
tacttcagg  actcttttt  aaactcaca  cacagtaca  ctggagatt  tctaagagg  2580
agcctcctg  caccacacc  ttgcgaaca  cggaggatc  gataaatgc  tgtagtcat  2640
atggcttaa  ttatccatg  gttcacgtc  taatatcat  tgattcttt  gctgataaa  2700
attatacag  agatctttc  aaattacag  ctcttatat  tggtccttc  tttgacata  2760
cttccatta  tccgttctt  gagccactt  cagaagaca  tattgccgg  ctcagtgtc  2820
atgttctgt  tcgtacacg  ttgaaagag  atgaacagt  catagacat  ctgttagag  2880
gatgcccgg  ggcagtcat  ccatatgct  atcatgaac  gaaagaaga  aaccggact  2940
tgtggtgga  aaaactgtt  cctgaactt  gtcagagaa  aaaatgtgg  ggagagaag  3000
atcaactct  cctgtcatc  ttaaaagaa  cattgtcaa  tgttgctgt  gaactagaa  3060
tgaaggatt  catgaatgt  ctcccagaa  atggtactg  aacattttt  ttgccatat  3120
ttctctatt  cagtcgaaa  aaaccattg  cttaaaggt  tcatttgaa  aataccata  3180
tggcatttg  gactgaatt  ctaaaaatt  aatgccaaa  tacaagtag  ggagttttt  3240
attttatat  tacacacac  cacacacac  cacacacac  cacacacat  tatgataca  3300
atgctttca  gctgcttac  ttaccgtgt  gtggtaact  ttcacttct  aatttatga  3360
ctcaatcaa  ttaattgtc  agaatgtaa  aagtcttta  gacataaga  ttcctcaaa  3420
aagccatac  ttttttaag  tggggattg  cttttattc  aaggaacaa  atcagttca  3480
tgttgttgg  gacatgaca  tcattttca  cccaagaac  ctttaagga  acattttac  3540
agtatgctt  aaagaatgt  actaactgg  ccagaattt  atcttcttg  tttttccag  3600
tttctctat  tttttgaga  agatgttaa  gttttgcca  ggtaaaaga  ttcaaacct  3660
atttttttt  ttccttttc  tgttacttt  aagaaaact  atgctctgt  tctctgaat  3720
aaatgaagt  gaagtttac  aagctaact  tcttcttgt  tagctatta  catgatttg  3780
caaatgcat  tttttttca  ccaaagcct  gtttccatt  ttgttgatg  gtactcttg  3840
tcttttagc  agagtgtat  tgaaaataa  gaaatacat  attgtattc  caaaaaaaa  3900
aaaaaaaaa  aa  3912



<210> 7459
<211> 1004
<212> PRT
<213> Homo sapiens
<308> Q969F9
<400> 7459

Met Val Gln Leu Tyr Asn Leu His Pro Phe Gly Ser Gln Gln Val Val 
  1               5                  10                  15
Pro Cys Lys Leu Glu Pro Asp Arg Phe Cys Gly Gly Gly Arg Asp Ala 
             20                  25                  30
Leu Phe Val Ala Ala Gly Cys Lys Val Glu Ala Phe Ala Val Ala Gly 
         35                  40                  45
Gln Glu Leu Cys Gln Pro Arg Cys Ala Phe Ser Thr Leu Gly Arg Val 
     50                  55                  60
Leu Arg Leu Ala Tyr Ser Glu Ala Gly Asp Tyr Leu Val Ala Ile Glu 
 65                  70                  75                  80
Glu Lys Asn Lys Ala Thr Phe Leu Arg Ala Tyr Val Asn Trp Arg Asn 
                 85                  90                  95
Lys Arg Thr Glu Asn Ser Arg Val Cys Ile Arg Met Ile Gly His Asn 
             100                105                110
Val Glu Gly Pro Phe Ser Lys Ala Phe Arg Asp Gln Met Tyr Ile Ile 
         115                120                125
Glu Met Pro Leu Ser Glu Ala Pro Leu Cys Ile Ser Cys Cys Pro Val 
     130                135                140
Lys Gly Asp Leu Leu Val Gly Cys Thr Asn Lys Leu Val Leu Phe Ser 
 145                150                155                160
Leu Lys Tyr Gln Ile Ile Asn Glu Glu Phe Ser Leu Leu Asp Phe Glu 
                 165                170                175
Arg Ser Leu Ile Ile His Ile Asp Asn Ile Thr Pro Val Glu Val Ser 
             180                185                190
Phe Cys Val Gly Tyr Val Ala Val Met Ser Asp Leu Glu Val Leu Ile 
         195                200                205
Val Lys Leu Glu Ser Gly Pro Lys Asn Gly Glu Arg Val His His His 
     210                215                220
Pro His Lys Thr Asn Asn Arg Ile Arg Arg Thr Glu Glu Gly Ile Ser 
 225                230                235                240
Asn Glu Ile Ser Gln Leu Glu Ser Asp Asp Phe Val Ile Cys Gln Lys 
                 245                250                255
Pro Leu Glu Leu Leu Gly Glu Lys Ser Glu Gln Ser Gly Leu Ser Val 
             260                265                270
Thr Leu Glu Ser Thr Gly Leu Ala Asp Glu Lys Arg Lys Tyr Ser His 
         275                280                285
Phe Gln His Leu Leu Tyr Arg Arg Phe Ala Pro Asp Ile Ser Ser Tyr 
     290                295                300
Val Leu Ser Asp Asp Ile Lys Leu His Ser Leu Gln Leu Leu Pro Ile 
 305                310                315                320
Tyr Gln Thr Gly Ser Leu Thr Ser Asp Gly Lys Asn Leu Ser Gln Glu 
                 325                330                335
Lys Glu Leu Leu Ser Leu Phe Cys Phe Phe Ser Leu Pro His Val Gly 
             340                345                350
Tyr Leu Tyr Met Val Val Lys Ser Val Glu Leu Met Ser Val Tyr Gln 
         355                360                365
Tyr Pro Glu Lys Ser Gln Gln Ala Val Leu Thr Pro Gln Phe Leu His 
     370                375                380
Val Ile Thr Ser Asn Asn Leu Gln Cys Phe Thr Val Arg Cys Ser Ala 
 385                390                395                400
Ala Ala Ala Arg Glu Glu Asp Pro Tyr Met Asp Thr Thr Leu Lys Ala 
                 405                410                415
Cys Pro Pro Val Ser Met Asp Val Cys Ala Leu Arg Ile Gln Leu Phe 
             420                425                430
Ile Gly Leu Lys Ala Ile Cys His Phe Lys Asn His Ile Ile Leu Leu 
         435                440                445
Thr Lys Ala Glu Pro Glu Ala Ile Pro Glu Arg Arg Gln Ser Pro Lys 
     450                455                460
Arg Leu Leu Ser Arg Lys Asp Thr Ser Val Lys Ile Lys Ile Pro Pro 
 465                470                475                480
Val Ala Glu Ala Gly Trp Asn Leu Tyr Ile Val Asn Thr Ile Ser Pro 
                 485                490                495
Val Gln Leu Tyr Lys Glu Met Val Asp Tyr Ser Asn Thr Tyr Lys Thr 
             500                505                510
Val Lys Thr Gln Ser Cys Ile His Leu Leu Ser Glu Ala His Leu Leu 
         515                520                525
Val Arg Ala Ala Leu Met Asp Ala Ser Gln Leu Glu Pro Gly Glu Lys 
     530                535                540
Ala Glu Leu Leu Glu Ala Phe Lys Glu Ser Cys Gly His Leu Gly Asp 
 545                550                555                560
Cys Tyr Ser Arg Leu Asp Ser Gln His Ser His Leu Thr Leu Pro Tyr 
                 565                570                575
Tyr Lys Met Ser Gly Leu Ser Met Ala Glu Val Leu Ala Arg Thr Asp 
             580                585                590
Trp Thr Val Glu Asp Gly Leu Gln Lys Tyr Glu Arg Gly Leu Ile Phe 
         595                600                605
Tyr Ile Asn His Ser Leu Tyr Glu Asn Leu Asp Glu Glu Leu Asn Glu 
     610                615                620
Glu Leu Ala Ala Lys Val Val Gln Met Phe Tyr Val Ala Glu Pro Lys 
 625                630                635                640
Gln Val Pro His Ile Leu Cys Ser Pro Ser Met Lys Asn Ile Asn Pro 
                 645                650                655
Leu Thr Ala Met Ser Tyr Leu Arg Lys Leu Asp Thr Ser Gly Phe Ser 
             660                665                670
Ser Ile Leu Val Thr Leu Thr Lys Ala Ala Val Ala Leu Lys Met Gly 
         675                680                685
Asp Leu Asp Met His Arg Asn Glu Met Lys Ser His Ser Glu Met Lys 
     690                695                700
Leu Val Cys Gly Phe Ile Leu Glu Pro Arg Leu Leu Ile Gln Gln Arg 
 705                710                715                720
Lys Gly Gln Ile Val Pro Thr Glu Leu Ala Leu His Leu Lys Glu Thr 
                 725                730                735
Gln Pro Gly Leu Leu Val Ala Ser Val Leu Gly Leu Gln Lys Asn Asn 
             740                745                750
Lys Ile Gly Ile Glu Glu Ala Asp Ser Phe Phe Lys Val Leu Cys Ala 
         755                760                765
Lys Asp Glu Asp Thr Ile Pro Gln Leu Leu Val Asp Phe Trp Glu Ala 
     770                775                780
Gln Leu Val Ala Cys Leu Pro Asp Val Val Leu Gln Glu Leu Phe Phe 
 785                790                795                800
Lys Leu Thr Ser Gln Tyr Ile Trp Arg Leu Ser Lys Arg Gln Pro Pro 
                 805                810                815
Asp Thr Thr Pro Leu Arg Thr Ser Glu Asp Leu Ile Asn Ala Cys Ser 
             820                825                830
His Tyr Gly Leu Ile Tyr Pro Trp Val His Val Val Ile Ser Ser Asp 
         835                840                845
Ser Leu Ala Asp Lys Asn Tyr Thr Glu Asp Leu Ser Lys Leu Gln Ser 
     850                855                860
Leu Ile Cys Gly Pro Ser Phe Asp Ile Ala Ser Ile Ile Pro Phe Leu 
 865                870                875                880
Glu Pro Leu Ser Glu Asp Thr Ile Ala Gly Leu Ser Val His Val Leu 
                 885                890                895
Cys Arg Thr Arg Leu Lys Glu Tyr Glu Gln Cys Ile Asp Ile Leu Leu 
             900                905                910
Glu Arg Cys Pro Glu Ala Val Ile Pro Tyr Ala Asn His Glu Leu Lys 
         915                920                925
Glu Glu Asn Arg Thr Leu Trp Trp Lys Lys Leu Leu Pro Glu Leu Cys 
     930                935                940
Gln Arg Ile Lys Cys Gly Gly Glu Lys Tyr Gln Leu Tyr Leu Ser Ser 
 945                950                955                960
Leu Lys Glu Thr Leu Ser Ile Val Ala Val Glu Leu Glu Leu Lys Asp 
                 965                970                975
Phe Met Asn Val Leu Pro Glu Asp Gly Thr Ala Thr Phe Phe Leu Pro 
             980                985                990
Tyr Leu Leu Tyr Cys Ser Arg Lys Lys Pro Leu Thr 
         995                1000



<210> 7460
<211> 458
<212> DNA
<213> Rattus norvegicus
<308> AI639443
<400> 7460

ttggggggc  gggtcttta  attgcattt  cagtatttt  taatagtac  taaataaag  60
aattgttca  tgcactgtt  aatgtcatc  cttccatga  tttggacct  atggtcctc  120
aagcgtctt  gtatgtctc  tctcagtta  tctgtaaac  gcccttgac  atttgagcc  180
acatatcca  tgtcgagaa  gtcattggc  ttccgctgg  ggctgcccc  cagaatctc  240
gccttccga  gaccagtgg  ccctttaga  gaggctgtt  cggatgagc  gtgcccgcc  300
ggagatggg  agctgggct  gctgtaagg  accagggac  cctctgatc  aacccctgg  360
ttgtgtggg  ctttccgtg  ttcttcttg  cgctctgta  agtttatcc  gtcctgggt  420
tgatgctgc  actttacag  agttttagc  ggacaatc  458



<210> 7461
<211> 5324
<212> DNA
<213> Homo sapiens
<308> XM_031246
<400> 7461

tgttacgag  tgacttccg  caaaacccc  cagatgttg  agtggcagc  ggagagcct  60
caatcctgg  gtgccagcc  ccccgggga  acccagaac  caccatcta  tggaaaaaa  120
acaaagttc  aattgatga  aaggaagaa  gaataagta  ccgtggtgg  aaactgatg  180
tctccaata  caggaaaag  gatgcaggg  tgtatactt  tgttggtac  aatatggtg  240
gagaaaggg  cagtgaccc  gcagagctg  ctgtctttg  acgacccac  tttctcagg  300
ggccaatta  ccaggtggt  ctggaggaa  aagctgtag  atttcgttg  caagtccaa  360
gagatcctc  accaactgt  aggtggaaa  aggatgatg  agacttgcc  agaggaagg  420
atgacatca  agacgatta  acactaaga  ttaaaaaga  catgagtac  gatgaaggc  480
cctatatgt  tattgctga  aatcgggtt  gaaaaatgg  agcctctgc  acactcacc  540
tccgagctc  cccacagtt  gtggttcgg  caagagatc  gattgttgc  caaggtcga  600
cagtgacat  tccctgtga  actaaagga  acccacagc  agctgtttt  tggcagaaa  660
aaggcagcc  gaacctact  ttcccaaac  aaccccagc  gcccaacag  agatgctca  720
tgtcaccaa  tggagacct  acaatcacc  acattcaac  ttccgacgc  ggttactac  780
tctgacagg  tttaactgt  gcaggaagc  ttttagcaa  agctcaact  gaggttact  840
atgttttga  agatagacc  ccacctata  ttctacaag  cccagccaa  caaacgctg  900
cagtggatg  tacagcgtt  ctgaaatgt  aagccactg  tgatcctct  cctgtaatt  960
gctggttaa  ggagggatt  acttttccg  gtagagatc  aagagcaac  attcaagag  1020
aaggcacac  gcagattaa  aatttacgg  tttctgata  tggcactta  acttgtgtg  1080
ctacaagtt  aagtggaga  acttcctgg  gtgcagtgc  ggatgtgac  gagtctgga  1140
caacaatca  taaaaacta  gatttaagt  acctgccag  gccaccatc  aaaccgcag  1200
tcactgatg  tactaagaa  agtgtcacc  tgtcctggc  gccaggtac  cctggaacc  1260
ttccagcaa  tgcatatat  attgaggct  tcagccaat  agtgagcaa  agctggcag  1320
ccgtggcaa  ccatgtaaa  accaccctc  atactgtaa  aggactgcg  cccaataca  1380
tctacttat  catggtcag  gcgatcaac  cccaaggtc  cagtgaccc  agtcccatg  1440
cagatcctg  gcgcacaca  gatatcagc  caccagcac  aggagtgga  cacaggcaa  1500
tgcagaaag  gctaggaga  gtccttgtc  gtcttcata  tccagttgt  ctgactccc  1560
ccacggttc  ggtcacatg  acggttgat  gccaacccc  gtttatcca  ggctaccga  1620
tgatgtatc  tcagacttc  ggtctgcag  cgacatctt  gtggcagaa  ttagatgcc  1680
aagtcccga  tgaacgaag  gctgtctta  tcaacctga  aaagggggt  acttatgaa  1740
ttaaagtac  gccatattt  aatgagttc  aaggaatgg  tagtgaatc  aaaacggtt  1800
gtactactg  agaagcccc  agtgcccca  cacagtctg  cactgtact  acagttgga  1860
gctacaata  cacaagtat  agtgtttcc  gggatcctc  tcctccaga  caccagaat  1920
gaattatcc  agaatacaa  atctggtgt  taggaaatg  aacgcgatt  catatcaac  1980
aaactgtgg  tgcagccat  cggtccgta  taattggtg  attattccc  ggtattcaa  2040
accgggtag  ggttgcagc  agtaccagt  caggggttg  agtaaagag  gagccacag  2100
caataataa  cgggagacg  aatgaagtt  tcattactg  aaacaataa  agcataact  2160
agcaaatca  tgatgtggt  aagcaacca  cctttatag  tggtattgg  ggtgcctgc  2220
gggtaattc  gatgggttt  agcatatgg  tgtattggc  aagaaagaa  aggaaggga  2280
tcagtaatt  tgctgttac  tttcaaaga  gagatggag  actaatgag  aatggaagc  2340
gtccaggtc  tctcaatgc  ggtgatccc  gctatccat  gcttgctga  tcttggcca  2400
ccacgagct  gccagtaaa  aatagcaac  gtggcccaa  tgagattgg  aattttggc  2460
gtggagatg  gctgccacc  gttccaggc  aaggggata  aacagcaac  atgctctca  2520
atggagcca  ttatagtag  attgacttc  ctaccaaaa  cagttacaa  agttccagc  2580
aaataacac  ggctacccc  tatgccacg  cacagatct  gcattccaa  agcatacat  2640
aattggctg  cgatctgcc  gatccacaa  ggaaaagct  aattcagca  aaaacagat  2700
tgatgggat  tggttattc  ctacctgat  agaacaaag  taacaatgg  gggaaaggt  2760
gaaaaaaga  gaaaaataa  aactcttct  aaccacaga  aaacaatgg  tccacttgg  2820
ccaatgtcc  tctacctcc  cccccagtc  agccccttc  tggcacgga  ctggaacac  2880
atgcagtgg  acaacaaga  aatggctat  acagtgata  ctggtgccc  ccattgcca  2940
tacaaactt  cttacacca  ggtctggaa  atgaactgg  agaagatga  gatagggtc  3000
caacacctc  tgttcgagg  gtggcttct  ctcctgcta  ctcctttgg  cagcagtcc  3060
ctgcaactc  tactccatc  ccacgggaa  agatgcaac  catgctgca  gctcacctg  3120
atgagttga  aagagccta  cagtttgat  tagcaaaac  aacatggca  attcaaagc  3180
ataatcaac  tccacagcc  ccagttcca  cgttaggtt  tgtgtctgg  gccttgatt  3240
ctgatttgg  aacggatgt  gcagatgat  atgccgacg  cgaagagga  gctttagaa  3300
tccccaggc  cctgagagc  ctggaccag  ctcctggat  cagcatgga  aatctagac  3360
gctctgtga  agcaatatt  ggtatcttc  tatgttatc  ctaggtaga  ttacaggtt  3420
gtcatagtg  agaaatata  gacagaatc  gtgtgctat  atgtcattc  ctagaaccc  3480
ttcccttta  tttcatttt  ggaaaagcc  ttacctcct  tcaaagacc  cgacctacc  3540
gcccatttt  tactgacag  aacaccagt  cagccctga  tcaaagtca  aggcctcgg  3600
ccactaaaa  acacaaggg  gggcggatg  accaacaac  agcattgcc  catcgaagg  3660
aaggaatga  agatgagga  gccttggtg  cctatagca  gcccagttt  ccatctcca  3720
gtggccaca  ctcatcagg  acagcttct  ctaagggat  cactggacc  aggaaaacc  3780
aggtgttga  agcaggcca  cagcgcaat  ccagcgacc  tcttgacat  ggatatatg  3840
gctccaaca  tcaaggaca  tttacagag  aaatgagag  agacataca  agctgctct  3900
aaggaccat  aggtccgga  tcatggaag  gatgactct  aacagtgca  tgaacaatt  3960
atttatgta  tattaaaag  actgtaaat  caatgtaaa  acacacagc  acacatatc  4020
cacagatat  ttcattgtg  tcttctctt  agtacacca  ccaccttaa  tctttcttg  4080
caggagtat  taaaaaaga  agaaaacaa  actcgccct  caggaagaa  aggattctc  4140
tctgtatat  atttctttt  tgcattgct  tgcaagctc  ctcttttta  ctctgctca  4200
attattgtc  gttcttatt  gtctgttgt  ctatatgtg  attaatagg  tgtggtgcc  4260
tatattaac  tttaattgt  taactttta  gtttaaatt  tgcactgca  ttttatttg  4320
tgataagca  aaatctcta  tcctcatga  atgaagaaa  agactgaat  tgaagggag  4380
ttctgtact  taagctaga  tggataatg  tggctgtaa  aaatcatgt  agatggttt  4440
cagttgggg  gtagaaata  gaagatgca  aggaacaat  gtgttggca  agtcttctt  4500
gaatatcag  gactgagtc  ataaaaaaa  tagtagaaa  gtggctttt  ctattgaca  4560
aagccgggg  caaaaaaag  agtttaagt  ttaagactg  atatgcatt  aagtatgca  4620
gtagcaaag  tgtaataaa  ttgcttaaa  aaagaaatt  aagttttat  tagaatcaa  4680
tttacctgt  attgtaatt  acccatctg  gaattacaa  aagcaagag  aaattaagg  4740
gttttgcaa  agctgtatt  atattacag  tttttaaaa  cattttctg  attatcgta  4800
ttaagctct  caactcgtt  agtcagaat  taatatgaa  ttccccaag  aaacgaaca  4860
aatgaactc  agaatatct  gcaaatagt  aaagaagca  tttattatt  gggcatact  4920
gggctgttt  caaatataa  ctctattgc  atatcttat  tcatctttc  aatacatgt  4980
cagtgcaca  tagaggata  agctgcatc  cttaaattc  tgacttaaa  aataataca  5040
tttatatac  acttgtttt  tatttgatt  agaagtgaa  tttacgcca  ccaatgtat  5100
gccaaattg  acgtgctta  aaaacagtg  cgagagtat  ttcagttcg  agtaagtag  5160
tttattgga  taaatattc  atggtacat  ctcagaaat  ggcttccaa  taaaatacg  5220
ttgacccat  ttgaataag  aaattgaaa  gaaaaattt  aaaggagaa  aaaatgcat  5280
tttataaac  ttttaaata  aaccagacc  tgtaagtgg  catt  5324



<210> 7462
<211> 670
<212> PRT
<213> Homo sapiens
<308> XP_031246
<400> 7462

Met Val Arg Ala Ile Asn Pro Gln Gly Leu Ser Asp Pro Ser Pro Met 
  1               5                  10                  15
Ser Asp Pro Val Arg Thr Gln Asp Ile Ser Pro Pro Ala Gln Gly Val 
             20                  25                  30
Asp His Arg Gln Val Gln Lys Glu Leu Gly Asp Val Leu Val Arg Leu 
         35                  40                  45
His Asn Pro Val Val Leu Thr Pro Thr Thr Val Gln Val Thr Trp Thr 
     50                  55                  60
Val Asp Arg Gln Pro Gln Phe Ile Gln Gly Tyr Arg Val Met Tyr Arg 
 65                  70                  75                  80
Gln Thr Ser Gly Leu Gln Ala Thr Ser Ser Trp Gln Asn Leu Asp Ala 
                 85                  90                  95
Lys Val Pro Thr Glu Arg Ser Ala Val Leu Val Asn Leu Lys Lys Gly 
             100                105                110
Val Thr Tyr Glu Ile Lys Val Arg Pro Tyr Phe Asn Glu Phe Gln Gly 
         115                120                125
Met Asp Ser Glu Ser Lys Thr Val Arg Thr Thr Glu Glu Ala Pro Ser 
     130                135                140
Ala Pro Pro Gln Ser Val Thr Val Leu Thr Val Gly Ser Tyr Asn Ser 
 145                150                155                160
Thr Ser Ile Ser Val Ser Trp Asp Pro Pro Pro Pro Asp His Gln Asn 
                 165                170                175
Gly Ile Ile Gln Glu Tyr Lys Ile Trp Cys Leu Gly Asn Glu Thr Arg 
             180                185                190
Phe His Ile Asn Lys Thr Val Asp Ala Ala Ile Arg Ser Val Ile Ile 
         195                200                205
Gly Gly Leu Phe Pro Gly Ile Gln Tyr Arg Val Glu Val Ala Ala Ser 
     210                215                220
Thr Ser Ala Gly Val Gly Val Lys Ser Glu Pro Gln Pro Ile Ile Ile 
 225                230                235                240
Gly Arg Arg Asn Glu Val Val Ile Thr Glu Asn Asn Asn Ser Ile Thr 
                 245                250                255
Glu Gln Ile Thr Asp Val Val Lys Gln Pro Ala Phe Ile Ala Gly Ile 
             260                265                270
Gly Gly Ala Cys Trp Val Ile Leu Met Gly Phe Ser Ile Trp Leu Tyr 
         275                280                285
Trp Arg Arg Lys Lys Arg Lys Gly Leu Ser Asn Tyr Ala Val Thr Phe 
     290                295                300
Gln Arg Gly Asp Gly Gly Leu Met Ser Asn Gly Ser Arg Pro Gly Leu 
 305                310                315                320
Leu Asn Ala Gly Asp Pro Ser Tyr Pro Trp Leu Ala Asp Ser Trp Pro 
                 325                330                335
Ala Thr Ser Leu Pro Val Asn Asn Ser Asn Ser Gly Pro Asn Glu Ile 
             340                345                350
Gly Asn Phe Gly Arg Gly Asp Val Leu Pro Pro Val Pro Gly Gln Gly 
         355                360                365
Asp Lys Thr Ala Thr Met Leu Ser Asp Gly Ala Ile Tyr Ser Ser Ile 
     370                375                380
Asp Phe Thr Thr Lys Thr Ser Tyr Asn Ser Ser Ser Gln Ile Thr Gln 
 385                390                395                400
Ala Thr Pro Tyr Ala Thr Thr Gln Ile Leu His Ser Asn Ser Ile His 
                 405                410                415
Glu Leu Ala Val Asp Leu Pro Asp Pro Gln Trp Lys Ser Ser Ile Gln 
             420                425                430
Gln Lys Thr Asp Leu Met Gly Phe Gly Tyr Ser Leu Pro Asp Gln Asn 
         435                440                445
Lys Gly Asn Asn Gly Gly Lys Gly Gly Lys Lys Lys Lys Asn Lys Asn 
     450                455                460
Ser Ser Lys Pro Gln Lys Asn Asn Gly Ser Thr Trp Ala Asn Val Pro 
 465                470                475                480
Leu Pro Pro Pro Pro Val Gln Pro Leu Pro Gly Thr Glu Leu Glu His 
                 485                490                495
Tyr Ala Val Glu Gln Gln Glu Asn Gly Tyr Asp Ser Asp Ser Trp Cys 
             500                505                510
Pro Pro Leu Pro Val Gln Thr Tyr Leu His Gln Gly Leu Glu Asp Glu 
         515                520                525
Leu Glu Glu Asp Asp Asp Arg Val Pro Thr Pro Pro Val Arg Gly Val 
     530                535                540
Ala Ser Ser Pro Ala Ile Ser Phe Gly Gln Gln Ser Thr Ala Thr Leu 
 545                550                555                560
Thr Pro Ser Pro Arg Glu Glu Met Gln Pro Met Leu Gln Ala His Leu 
                 565                570                575
Asp Glu Leu Thr Arg Ala Tyr Gln Phe Asp Ile Ala Lys Gln Thr Trp 
             580                585                590
His Ile Gln Ser Asn Asn Gln Pro Pro Gln Pro Pro Val Pro Pro Leu 
         595                600                605
Gly Tyr Val Ser Gly Ala Leu Ile Ser Asp Leu Glu Thr Asp Val Ala 
     610                615                620
Asp Asp Asp Ala Asp Asp Glu Glu Glu Ala Leu Glu Ile Pro Arg Pro 
 625                630                635                640
Leu Arg Ala Leu Asp Gln Thr Pro Gly Ser Ser Met Asp Asn Leu Asp 
                 645                650                655
Ser Ser Val Thr Ala Ile Phe Gly Ile Phe Ile Cys Tyr Leu 
             660                665                670



<210> 7463
<211> 409
<212> DNA
<213> Rattus norvegicus
<308> AI639461
<400> 7463

ttaaatggg  gctttgtgc  ccccccaca  acacatagg  ctccacata  tatgagtgg  60
tggtagcct  tgcaaatga  aaccggaac  taatcaaat  tgacttgta  atcagcaaa  120
gaaacgtgt  tctccagaa  tcaagatgt  aaagataca  tttaccggt  ctgtataca  180
tccgcctta  gggtccatc  gctttgaat  ttctagacg  acacctctg  ggaaatcta  240
tgtgttttg  ggcaggaga  atcaggcag  tccaaattc  cgtcttggg  aggtcttca  300
accctgcgc  tggagacgc  gcttggcat  gtctttagc  ggagcgatc  tttcagtgt  360
agcctgcat  tcctttgga  cttgactcc  attcacaga  cacgtcccg  409



<210> 7464
<211> 315
<212> DNA
<213> Rattus norvegicus
<308> AI639465
<400> 7464

ttgggagtt  caggaaaag  gcgctgtga  tttattttt  attcttttt  attttttta  60
ttttgagac  gagagtctc  ctatgttgc  ctggctggt  tggaactct  catgtagac  120
aggctagcc  cgaactcat  gagatccaa  tgcctctgc  tccagagtg  tgggatcaa  180
gggtgtgca  cccccaata  ccagcccct  ctgcattta  taaaacaac  tataacaca  240
attcagtcc  ctccccatg  ttggggatg  gtactgaag  tcagtacat  gcccctttc  300
aggcctttg  gtgag  315



<210> 7465
<211> 1903
<212> DNA
<213> Homo sapiens
<308> AF361946
<400> 7465

ttaagtaaa  taagtgccg  ggggtggag  acgggctgg  tggagtggg  gtctccatc  60
tctccagca  aaggctgtg  tgaagtctg  gcaaaggga  gggctcaga  agaggggct  120
cccgaccct  ccatctagg  gctgcccag  actccagag  aggggaagg  attgattta  180
gtcagtgag  ggttgcgtg  ggctgggag  gggttgagg  tgggaggct  aaggaggag  240
ctcccttca  cctgggagg  ggaggttgc  gtgagcaga  atcgtgcca  tgcacaatc  300
tttctatct  ccttcctgg  ctgtgagtt  ctcggggca  ggaaacaga  cactcatcc  360
tctgtcacg  tgtgatgta  actagttac  tgatttata  actagtact  agaaaaatg  420
ctgatgaat  aataaaatt  atccatgaa  cattttcat  atagcattg  ctattaacc  480
cttgaatcc  cgtggctca  ttgctgggt  ccatccctg  cccactaac  tggtgccgt  540
gggacacca  tttttggag  aaagctctg  gtacccttt  ttgccctaa  cctgcctct  600
aacaggctg  tcttgttta  gacccccgt  ccagcagaa  agtgattgc  catccctgc  660
tgtgatttg  gagggccag  ctttcaggc  tggaggaaa  tcaagcccc  ccagcccgc  720
tggcatcgg  atgctcagc  agtcccctc  tggggctca  gtgaccaag  tctagctat  780
aatatcaga  gggcctcag  ccaagacag  attcgggca  caggagaag  aaagccaac  840
ggatccgac  cggtgtttt  tgacaaagg  aagaccccc  ggtctactt  gagcaaagt  900
agtacagga  gcagctagg  gtggctctc  ttccttccc  cagaaagga  tataagtcg  960
gcctgatcc  ggaagggaa  cccatggag  acttggaga  gcagctgat  tgccctatc  1020
gcctggaga  gtttaccaa  ccagtggtc  tcttgccgt  ccagcacaa  ctgtgccgg  1080
agtgtgcca  tgacatctt  caggctgca  atccctact  gaccagccg  ggcagctca  1140
tgtccatgt  tggaggccg  ttccgctgc  ccacctgcc  ccacgaagt  atcatggat  1200
gtcacggag  gtacggcct  cagaggaac  tgctggtgg  gaacatcat  gacatctac  1260
aacaggagt  ctccagtcg  ccgctgcag  agggcagtc  ccccatgtg  aaggagcac  1320
aagatgaga  aatcaacat  tactgtctc  cgtgtgagg  gcccaccct  ttccatggc  1380
aggttttgg  atccaaagg  ctggggggg  gccccttgc  gccccaggg  ggggggtcg  1440
ggcccctgg  gggcaatgg  gaggtgatt  ttttttttg  tcagggggc  gggattagg  1500
taggaccct  accgtgggt  cagcagaca  tgaaccaga  ttggaaacg  gctttgaaa  1560
aatcacaca  gacactttt  tacattggg  aaaatggaa  attttgtac  tttttaaaa  1620
gtgattttt  taaatactt  tatatgtat  ccaatttgg  gctttttgt  aaggaactt  1680
tgtataata  tgcctggtc  ttggggacc  gcgattgtc  gaaagaggg  aaggaagcc  1740
ggttgatac  gctgcccat  tcctttcct  agcaggagg  tggggtagc  ctcacaggg  1800
cgatgtgct  tatttcagt  tttatccca  acatacggg  tggtaaatg  gtttgtgtt  1860
tatgttgtt  taataaatg  acaatgctt  tttcctgtt  ttc  1903



<210> 7466
<211> 353
<212> PRT
<213> Homo sapiens
<308> Q969Q1
<400> 7466

Met Asp Tyr Lys Ser Ser Leu Ile Gln Asp Gly Asn Pro Met Glu Asn 
  1               5                  10                  15
Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met Phe Thr Lys 
             20                  25                  30
Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg Lys Cys Ala 
         35                  40                  45
Asn Asp Ile Phe Gln Ala Ala Asn Pro Tyr Trp Thr Ser Arg Gly Ser 
     50                  55                  60
Ser Val Ser Met Ser Gly Gly Arg Phe Arg Cys Pro Thr Cys Arg His 
 65                  70                  75                  80
Glu Val Ile Met Asp Arg His Gly Val Tyr Gly Leu Gln Arg Asn Leu 
                 85                  90                  95
Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Cys Ser Ser Arg 
             100                105                110
Pro Leu Gln Lys Gly Ser His Pro Met Cys Lys Glu His Glu Asp Glu 
         115                120                125
Lys Ile Asn Ile Tyr Cys Leu Thr Cys Glu Val Pro Thr Cys Ser Met 
     130                135                140
Cys Lys Val Phe Gly Ile His Lys Ala Cys Glu Val Ala Pro Leu Gln 
 145                150                155                160
Ser Val Phe Gln Gly Gln Lys Thr Glu Leu Asn Asn Cys Ile Ser Met 
                 165                170                175
Leu Val Ala Gly Asn Asp Arg Val Gln Thr Ile Ile Thr Gln Leu Glu 
             180                185                190
Asp Ser Arg Arg Val Thr Lys Glu Asn Ser His Gln Val Lys Glu Glu 
         195                200                205
Leu Ser Gln Lys Phe Asp Thr Leu Tyr Ala Ile Leu Asp Glu Lys Lys 
     210                215                220
Ser Glu Leu Leu Gln Arg Ile Thr Gln Glu Gln Glu Lys Lys Leu Ser 
 225                230                235                240
Phe Ile Glu Ala Leu Ile Gln Gln Tyr Gln Glu Gln Leu Asp Lys Ser 
                 245                250                255
Thr Lys Leu Val Glu Thr Ala Ile Gln Ser Leu Asp Glu Pro Gly Gly 
             260                265                270
Ala Thr Phe Leu Leu Thr Ala Lys Gln Leu Ile Lys Ser Ile Val Glu 
         275                280                285
Ala Ser Lys Gly Cys Gln Leu Gly Lys Thr Glu Gln Gly Phe Glu Asn 
     290                295                300
Met Asp Phe Phe Thr Leu Asp Leu Glu His Ile Ala Asp Ala Leu Arg 
 305                310                315                320
Ala Ile Asp Phe Gly Thr Asp Glu Glu Glu Glu Glu Phe Ile Glu Glu 
                 325                330                335
Glu Asp Gln Glu Glu Glu Glu Ser Thr Glu Gly Lys Glu Glu Gly His 
             340                345                350
Gln 
         355



<210> 7467
<211> 315
<212> DNA
<213> Rattus norvegicus
<308> AI639465
<400> 7467

ttgggagtt  caggaaaag  gcgctgtga  tttattttt  attcttttt  attttttta  60
ttttgagac  gagagtctc  ctatgttgc  ctggctggt  tggaactct  catgtagac  120
aggctagcc  cgaactcat  gagatccaa  tgcctctgc  tccagagtg  tgggatcaa  180
gggtgtgca  cccccaata  ccagcccct  ctgcattta  taaaacaac  tataacaca  240
attcagtcc  ctccccatg  ttggggatg  gtactgaag  tcagtacat  gcccctttc  300
aggcctttg  gtgag  315



<210> 7468
<211> 1903
<212> DNA
<213> Homo sapiens
<308> AF361946
<400> 7468

ttaagtaaa  taagtgccg  ggggtggag  acgggctgg  tggagtggg  gtctccatc  60
tctccagca  aaggctgtg  tgaagtctg  gcaaaggga  gggctcaga  agaggggct  120
cccgaccct  ccatctagg  gctgcccag  actccagag  aggggaagg  attgattta  180
gtcagtgag  ggttgcgtg  ggctgggag  gggttgagg  tgggaggct  aaggaggag  240
ctcccttca  cctgggagg  ggaggttgc  gtgagcaga  atcgtgcca  tgcacaatc  300
tttctatct  ccttcctgg  ctgtgagtt  ctcggggca  ggaaacaga  cactcatcc  360
tctgtcacg  tgtgatgta  actagttac  tgatttata  actagtact  agaaaaatg  420
ctgatgaat  aataaaatt  atccatgaa  cattttcat  atagcattg  ctattaacc  480
cttgaatcc  cgtggctca  ttgctgggt  ccatccctg  cccactaac  tggtgccgt  540
gggacacca  tttttggag  aaagctctg  gtacccttt  ttgccctaa  cctgcctct  600
aacaggctg  tcttgttta  gacccccgt  ccagcagaa  agtgattgc  catccctgc  660
tgtgatttg  gagggccag  ctttcaggc  tggaggaaa  tcaagcccc  ccagcccgc  720
tggcatcgg  atgctcagc  agtcccctc  tggggctca  gtgaccaag  tctagctat  780
aatatcaga  gggcctcag  ccaagacag  attcgggca  caggagaag  aaagccaac  840
ggatccgac  cggtgtttt  tgacaaagg  aagaccccc  ggtctactt  gagcaaagt  900
agtacagga  gcagctagg  gtggctctc  ttccttccc  cagaaagga  tataagtcg  960
gcctgatcc  ggaagggaa  cccatggag  acttggaga  gcagctgat  tgccctatc  1020
gcctggaga  gtttaccaa  ccagtggtc  tcttgccgt  ccagcacaa  ctgtgccgg  1080
agtgtgcca  tgacatctt  caggctgca  atccctact  gaccagccg  ggcagctca  1140
tgtccatgt  tggaggccg  ttccgctgc  ccacctgcc  ccacgaagt  atcatggat  1200
gtcacggag  gtacggcct  cagaggaac  tgctggtgg  gaacatcat  gacatctac  1260
aacaggagt  ctccagtcg  ccgctgcag  agggcagtc  ccccatgtg  aaggagcac  1320
aagatgaga  aatcaacat  tactgtctc  cgtgtgagg  gcccaccct  ttccatggc  1380
aggttttgg  atccaaagg  ctggggggg  gccccttgc  gccccaggg  ggggggtcg  1440
ggcccctgg  gggcaatgg  gaggtgatt  ttttttttg  tcagggggc  gggattagg  1500
taggaccct  accgtgggt  cagcagaca  tgaaccaga  ttggaaacg  gctttgaaa  1560
aatcacaca  gacactttt  tacattggg  aaaatggaa  attttgtac  tttttaaaa  1620
gtgattttt  taaatactt  tatatgtat  ccaatttgg  gctttttgt  aaggaactt  1680
tgtataata  tgcctggtc  ttggggacc  gcgattgtc  gaaagaggg  aaggaagcc  1740
ggttgatac  gctgcccat  tcctttcct  agcaggagg  tggggtagc  ctcacaggg  1800
cgatgtgct  tatttcagt  tttatccca  acatacggg  tggtaaatg  gtttgtgtt  1860
tatgttgtt  taataaatg  acaatgctt  tttcctgtt  ttc  1903



<210> 7469
<211> 353
<212> PRT
<213> Homo sapiens
<308> Q969Q1
<400> 7469

Met Asp Tyr Lys Ser Ser Leu Ile Gln Asp Gly Asn Pro Met Glu Asn 
  1               5                  10                  15
Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met Phe Thr Lys 
             20                  25                  30
Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg Lys Cys Ala 
         35                  40                  45
Asn Asp Ile Phe Gln Ala Ala Asn Pro Tyr Trp Thr Ser Arg Gly Ser 
     50                  55                  60
Ser Val Ser Met Ser Gly Gly Arg Phe Arg Cys Pro Thr Cys Arg His 
 65                  70                  75                  80
Glu Val Ile Met Asp Arg His Gly Val Tyr Gly Leu Gln Arg Asn Leu 
                 85                  90                  95
Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Cys Ser Ser Arg 
             100                105                110
Pro Leu Gln Lys Gly Ser His Pro Met Cys Lys Glu His Glu Asp Glu 
         115                120                125
Lys Ile Asn Ile Tyr Cys Leu Thr Cys Glu Val Pro Thr Cys Ser Met 
     130                135                140
Cys Lys Val Phe Gly Ile His Lys Ala Cys Glu Val Ala Pro Leu Gln 
 145                150                155                160
Ser Val Phe Gln Gly Gln Lys Thr Glu Leu Asn Asn Cys Ile Ser Met 
                 165                170                175
Leu Val Ala Gly Asn Asp Arg Val Gln Thr Ile Ile Thr Gln Leu Glu 
             180                185                190
Asp Ser Arg Arg Val Thr Lys Glu Asn Ser His Gln Val Lys Glu Glu 
         195                200                205
Leu Ser Gln Lys Phe Asp Thr Leu Tyr Ala Ile Leu Asp Glu Lys Lys 
     210                215                220
Ser Glu Leu Leu Gln Arg Ile Thr Gln Glu Gln Glu Lys Lys Leu Ser 
 225                230                235                240
Phe Ile Glu Ala Leu Ile Gln Gln Tyr Gln Glu Gln Leu Asp Lys Ser 
                 245                250                255
Thr Lys Leu Val Glu Thr Ala Ile Gln Ser Leu Asp Glu Pro Gly Gly 
             260                265                270
Ala Thr Phe Leu Leu Thr Ala Lys Gln Leu Ile Lys Ser Ile Val Glu 
         275                280                285
Ala Ser Lys Gly Cys Gln Leu Gly Lys Thr Glu Gln Gly Phe Glu Asn 
     290                295                300
Met Asp Phe Phe Thr Leu Asp Leu Glu His Ile Ala Asp Ala Leu Arg 
 305                310                315                320
Ala Ile Asp Phe Gly Thr Asp Glu Glu Glu Glu Glu Phe Ile Glu Glu 
                 325                330                335
Glu Asp Gln Glu Glu Glu Glu Ser Thr Glu Gly Lys Glu Glu Gly His 
             340                345                350
Gln 
         355



<210> 7470
<211> 413
<212> DNA
<213> Rattus norvegicus
<308> AI639471
<400> 7470

ttgtttttt  aaacataaa  ccaactttt  tttttgaac  aaaccataa  taatttttt  60
taaaacaaa  cgggccccg  gggaaattt  aaggcctta  ccacccttc  aagaaggga  120
aaagtaaca  cccctgaaa  ctcgccgcc  cttgttttt  aaaacctgc  ttacctcca  180
aaaatgggc  gccccactt  gaggtcccc  gcccggttt  tgactgcgg  gggagaatc  240
ccaacttag  ccaaagcct  gcaaaaccc  ggggtgggg  gggcccaaa  agccacccg  300
ccaattttt  tttcggaaa  cacctgtta  gaaaggaaa  accaaggct  ttttccact  360
gaaacaaaa  aaggggcaa  gccgggccc  ctttctgaa  caacaatac  att  413



<210> 7471
<211> 413
<212> DNA
<213> Rattus norvegicus
<308> AI639471
<400> 7471

ttgtttttt  aaacataaa  ccaactttt  tttttgaac  aaaccataa  taatttttt  60
taaaacaaa  cgggccccg  gggaaattt  aaggcctta  ccacccttc  aagaaggga  120
aaagtaaca  cccctgaaa  ctcgccgcc  cttgttttt  aaaacctgc  ttacctcca  180
aaaatgggc  gccccactt  gaggtcccc  gcccggttt  tgactgcgg  gggagaatc  240
ccaacttag  ccaaagcct  gcaaaaccc  ggggtgggg  gggcccaaa  agccacccg  300
ccaattttt  tttcggaaa  cacctgtta  gaaaggaaa  accaaggct  ttttccact  360
gaaacaaaa  aaggggcaa  gccgggccc  ctttctgaa  caacaatac  att  413



<210> 7472
<211> 502
<212> DNA
<213> Rattus norvegicus
<308> AI639474
<400> 7472

ttcacgtgt  acatgattc  ttatgaaat  tccaggaga  acagaaaga  tgacgatta  60
ctagagaga  gagaaaatg  gggtacaaa  agttactgg  tttctttta  gaatgagaa  120
aaacaaatt  gaattacat  gaaatggtt  tagatttga  caaaaccag  gacttgcat  180
tttaaaaag  gtaaatatt  tatggtatg  aaactgcac  cagacacac  aaaaaggtg  240
acaaactaa  ttcttctct  ttgtctcag  ttacctact  agtcacaaa  atatagaaa  300
aagtgcaaa  acgcctgac  agtataacc  cactgcaac  agttcagta  aagcaggcc  360
tcggcctcc  gacctgggt  aaatccagg  cctcacacg  gccagtagg  aggactctt  420
cactgagct  tagccccaa  gcctttctc  ctcttttgg  cagggtcgt  tgtggtcca  480
actggcctt  agccaagtt  ga  502



<210> 7473
<211> 286
<212> DNA
<213> Rattus norvegicus
<308> AI639484
<400> 7473

ttccactaa  tagttttaa  aaaacgaaa  gtcaaaagt  agcatcagg  gatcccaca  60
cacagttga  actgttgaa  aagcaactc  caaagaagc  atcataaaa  acatcatga  120
cagcgaacg  tcttgctca  tgagggaac  gctcgtccc  ttagccctc  gtagaaacc  180
ctgggagtc  ctcagggca  aacaaaaaa  agaaaaaaa  agaaaagaa  tgatggcta  240
aaatgttgt  cattatatc  cagtgacct  ccacaggga  tgtttt  286



<210> 7474
<211> 1739
<212> DNA
<213> Homo sapiens
<308> AK000592
<400> 7474

actacatta  atgctggaa  tatcaaatt  gctttcaat  gtttactag  aaaggcaga  60
gcccgtgaa  gtgaaagag  aaaagaaga  gctcggaag  tgaaacgaa  agaatctgc  120
tttaagagt  tgttaaaac  agctgctcc  ccgatagaa  tggatgctg  ctgggaaga  180
atccgtgag  gatttgtaa  agagccagc  tttgaggac  taactctag  acctgaaag  240
aaacgaata  ttaaagatt  tatgcatgt  cttgagcat  aatgtcagc  tcatcattc  300
aagaacaag  aacattcta  gaaatctaa  aaacatcat  ggaaacgtt  ccgctctcg  360
tcggggtca  attcagatg  tgatgatag  cattcaaag  aaaaaagac  gcgatcaga  420
tctcgttct  cttcagaac  ttcttctag  gcagagtct  agagaagtt  taaaaagtc  480
aaaaagcat  agaagaaaa  taagaagag  agacataaa  ctgactctc  agaatccga  540
gctgagcga  agaaggata  aaaagaaaa  gatcgggaa  gtgaaaaag  cagaactag  600
caaagatca  aatcaaaac  caaatcgcc  aagaaaaag  ctggaaagg  ttctggtaa  660
tgggatact  ctggcagcg  actgagtga  ggggaattg  aaaagcgca  aagaaccct  720
ttggagcaa  tggatgatg  tcaataaat  ataccaaat  tatgtttac  gtatgattt  780
aagtctgat  cagaccagg  actctattt  aagttcaac  gaaataaca  tgggtttta  840
ttatatcac  ggaaaaaaa  agtgcattt  agtattgtt  tcgtggact  tataaaagc  900
aaggaaatt  aaagtaact  ttgattctg  atcaagaat  atattttca  acagtcata  960
ctgtctttc  gtgaccctt  cacagggca  tgtaggatg  attaaaggt  gcaatttac  1020
gataactgc  gatgtctct  ctttgttct  aaatctaag  catgaggtg  tttgattta  1080
tttatagaa  ctggatttt  aagatctaa  gaaaaattt  ttgataata  agtagtaca  1140
aaaaagcac  agcaactga  aaaaattgc  tttttgtgc  ctacccaac  ggttaaagc  1200
aatgtgatc  tttatggtg  aactcctaa  aaacaggtg  ttttgctgg  aacttggta  1260
acccttaat  atagtggtg  taatgagca  tactgtaat  taaagccac  attattttt  1320
atcaaacat  tgaatacat  ttacaaagg  tattgtgag  gcattattt  gagcatcta  1380
tttgaggtg  tgtttaaaa  aactttaac  tcaaatcaa  ttgtaaatt  atttaaata  1440
attgcctta  ggacctact  aagaatgtg  caccagact  taagtgata  ttgcaatat  1500
cttgtctaa  aaaaaaaaa  aagttgact  aaacatttt  tttaacagt  gtctttttt  1560
tctaaattc  gtctttctc  tgctttttt  tccctgcta  tgaggaagt  ttttgcctt  1620
cctactcac  gagaagtat  gacttcgtg  tacacattc  aaagcattt  tgatttgaa  1680
atttttgta  atttttatc  attattaaa  cttctcttc  aaaaaaaaa  aaaaaaaaa  1739



<210> 7475
<211> 216
<212> PRT
<213> Homo sapiens
<308> AK000592
<400> 7475

Met Lys Arg Lys Glu Ser Ala Phe Lys Ser Met Leu Lys Gln Ala Ala 
  1               5                  10                  15
Pro Pro Ile Glu Leu Asp Ala Val Trp Glu Asp Ile Arg Glu Arg Phe 
             20                  25                  30
Val Lys Glu Pro Ala Phe Glu Asp Ile Thr Leu Glu Pro Glu Arg Lys 
         35                  40                  45
Arg Ile Phe Lys Asp Phe Met His Val Leu Glu His Glu Cys Gln His 
     50                  55                  60
His His Ser Lys Asn Lys Lys His Ser Lys Lys Ser Lys Lys His His 
 65                  70                  75                  80
Arg Lys Arg Ser Arg Ser Arg Ser Gly Ser Asp Ser Asp Asp Asp Asp 
                 85                  90                  95
Ser His Ser Lys Lys Lys Arg Gln Arg Ser Glu Ser Arg Ser Ala Ser 
             100                105                110
Glu His Ser Ser Ser Ala Glu Ser Glu Arg Ser Tyr Lys Lys Ser Lys 
         115                120                125
Lys His Lys Lys Lys Ser Lys Lys Arg Arg His Lys Ser Asp Ser Pro 
     130                135                140
Glu Ser Asp Ala Glu Arg Glu Lys Asp Lys Lys Glu Lys Asp Arg Glu 
 145                150                155                160
Ser Glu Lys Asp Arg Thr Arg Gln Arg Ser Glu Ser Lys His Lys Ser 
                 165                170                175
Pro Lys Lys Lys Thr Gly Lys Asp Ser Gly Asn Trp Asp Thr Ser Gly 
             180                185                190
Ser Glu Leu Ser Glu Gly Glu Leu Glu Lys Arg Arg Arg Thr Leu Leu 
         195                200                205
Glu Gln Leu Asp Asp Asp Gln Ter 
     210                215



<210> 7476
<211> 286
<212> DNA
<213> Rattus norvegicus
<308> AI639484
<400> 7476

ttccactaa  tagttttaa  aaaacgaaa  gtcaaaagt  agcatcagg  gatcccaca  60
cacagttga  actgttgaa  aagcaactc  caaagaagc  atcataaaa  acatcatga  120
cagcgaacg  tcttgctca  tgagggaac  gctcgtccc  ttagccctc  gtagaaacc  180
ctgggagtc  ctcagggca  aacaaaaaa  agaaaaaaa  agaaaagaa  tgatggcta  240
aaatgttgt  cattatatc  cagtgacct  ccacaggga  tgtttt  286



<210> 7477
<211> 1739
<212> DNA
<213> Homo sapiens
<308> AK000592
<400> 7477

actacatta  atgctggaa  tatcaaatt  gctttcaat  gtttactag  aaaggcaga  60
gcccgtgaa  gtgaaagag  aaaagaaga  gctcggaag  tgaaacgaa  agaatctgc  120
tttaagagt  tgttaaaac  agctgctcc  ccgatagaa  tggatgctg  ctgggaaga  180
atccgtgag  gatttgtaa  agagccagc  tttgaggac  taactctag  acctgaaag  240
aaacgaata  ttaaagatt  tatgcatgt  cttgagcat  aatgtcagc  tcatcattc  300
aagaacaag  aacattcta  gaaatctaa  aaacatcat  ggaaacgtt  ccgctctcg  360
tcggggtca  attcagatg  tgatgatag  cattcaaag  aaaaaagac  gcgatcaga  420
tctcgttct  cttcagaac  ttcttctag  gcagagtct  agagaagtt  taaaaagtc  480
aaaaagcat  agaagaaaa  taagaagag  agacataaa  ctgactctc  agaatccga  540
gctgagcga  agaaggata  aaaagaaaa  gatcgggaa  gtgaaaaag  cagaactag  600
caaagatca  aatcaaaac  caaatcgcc  aagaaaaag  ctggaaagg  ttctggtaa  660
tgggatact  ctggcagcg  actgagtga  ggggaattg  aaaagcgca  aagaaccct  720
ttggagcaa  tggatgatg  tcaataaat  ataccaaat  tatgtttac  gtatgattt  780
aagtctgat  cagaccagg  actctattt  aagttcaac  gaaataaca  tgggtttta  840
ttatatcac  ggaaaaaaa  agtgcattt  agtattgtt  tcgtggact  tataaaagc  900
aaggaaatt  aaagtaact  ttgattctg  atcaagaat  atattttca  acagtcata  960
ctgtctttc  gtgaccctt  cacagggca  tgtaggatg  attaaaggt  gcaatttac  1020
gataactgc  gatgtctct  ctttgttct  aaatctaag  catgaggtg  tttgattta  1080
tttatagaa  ctggatttt  aagatctaa  gaaaaattt  ttgataata  agtagtaca  1140
aaaaagcac  agcaactga  aaaaattgc  tttttgtgc  ctacccaac  ggttaaagc  1200
aatgtgatc  tttatggtg  aactcctaa  aaacaggtg  ttttgctgg  aacttggta  1260
acccttaat  atagtggtg  taatgagca  tactgtaat  taaagccac  attattttt  1320
atcaaacat  tgaatacat  ttacaaagg  tattgtgag  gcattattt  gagcatcta  1380
tttgaggtg  tgtttaaaa  aactttaac  tcaaatcaa  ttgtaaatt  atttaaata  1440
attgcctta  ggacctact  aagaatgtg  caccagact  taagtgata  ttgcaatat  1500
cttgtctaa  aaaaaaaaa  aagttgact  aaacatttt  tttaacagt  gtctttttt  1560
tctaaattc  gtctttctc  tgctttttt  tccctgcta  tgaggaagt  ttttgcctt  1620
cctactcac  gagaagtat  gacttcgtg  tacacattc  aaagcattt  tgatttgaa  1680
atttttgta  atttttatc  attattaaa  cttctcttc  aaaaaaaaa  aaaaaaaaa  1739



<210> 7478
<211> 216
<212> PRT
<213> Homo sapiens
<308> AK000592
<400> 7478

Met Lys Arg Lys Glu Ser Ala Phe Lys Ser Met Leu Lys Gln Ala Ala 
  1               5                  10                  15
Pro Pro Ile Glu Leu Asp Ala Val Trp Glu Asp Ile Arg Glu Arg Phe 
             20                  25                  30
Val Lys Glu Pro Ala Phe Glu Asp Ile Thr Leu Glu Pro Glu Arg Lys 
         35                  40                  45
Arg Ile Phe Lys Asp Phe Met His Val Leu Glu His Glu Cys Gln His 
     50                  55                  60
His His Ser Lys Asn Lys Lys His Ser Lys Lys Ser Lys Lys His His 
 65                  70                  75                  80
Arg Lys Arg Ser Arg Ser Arg Ser Gly Ser Asp Ser Asp Asp Asp Asp 
                 85                  90                  95
Ser His Ser Lys Lys Lys Arg Gln Arg Ser Glu Ser Arg Ser Ala Ser 
             100                105                110
Glu His Ser Ser Ser Ala Glu Ser Glu Arg Ser Tyr Lys Lys Ser Lys 
         115                120                125
Lys His Lys Lys Lys Ser Lys Lys Arg Arg His Lys Ser Asp Ser Pro 
     130                135                140
Glu Ser Asp Ala Glu Arg Glu Lys Asp Lys Lys Glu Lys Asp Arg Glu 
 145                150                155                160
Ser Glu Lys Asp Arg Thr Arg Gln Arg Ser Glu Ser Lys His Lys Ser 
                 165                170                175
Pro Lys Lys Lys Thr Gly Lys Asp Ser Gly Asn Trp Asp Thr Ser Gly 
             180                185                190
Ser Glu Leu Ser Glu Gly Glu Leu Glu Lys Arg Arg Arg Thr Leu Leu 
         195                200                205
Glu Gln Leu Asp Asp Asp Gln Ter 
     210                215



<210> 7479
<211> 401
<212> DNA
<213> Rattus norvegicus
<308> AI639488
<400> 7479

ttagactaa  acaatgctc  ggctttaat  tatgaaaat  atacccatg  tgtctaatt  60
gggggtcat  cattagaag  gtaaaggtc  gcgtctgcc  gccgtctag  tgaagtacg  120
gagcacaat  atttggatc  gctgtctgc  cacggggca  ggcttattc  tcttcttta  180
cttctttgc  cacgtgaaa  atgacatca  gtgtccggt  ttgccgtga  caatgcaac  240
atttttagg  cgcccctgg  aaatcacac  tggctcgat  gcgttcaga  agaagctgg  300
ttccatact  tcctctttg  cttgtgtgt  ctccttcaa  tctttgcca  tttcttggc  360
gctgtaaac  atgctactg  aagtcgacg  ctgggaata  t  401



<210> 7480
<211> 489
<212> PRT
<213> Rattus norvegicus
<308> AAA91167
<400> 7480

Met Cys Asn Thr Asn Met Ser Val Ser Thr Glu Gly Ala Ala Ser Thr 
  1               5                  10                  15
Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
             20                  25                  30
Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Asn Asp Thr Tyr 
         35                  40                  45
Thr Met Lys Glu Ile Ile Phe Tyr Ile Gly Gln Tyr Ile Met Thr Lys 
     50                  55                  60
Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp 
 65                  70                  75                  80
Leu Leu Gly Asp Val Phe Gly Val Pro Ser Phe Ser Val Lys Glu His 
                 85                  90                  95
Arg Lys Ile Tyr Ala Met Ile Tyr Arg Asn Leu Val Ala Val Ser Gln 
             100                105                110
Gln Asp Ser Gly Thr Ser Leu Ser Glu Ser Arg Arg Gln Pro Glu Gly 
         115                120                125
Gly Ser Asp Leu Lys Asp Pro Leu Gln Ala Pro Pro Glu Glu Lys Pro 
     130                135                140
Ser Ser Ser Asp Leu Ile Ser Arg Leu Ser Thr Ser Ser Arg Arg Arg 
 145                150                155                160
Ser Ile Ser Glu Thr Glu Glu Asn Thr Asp Glu Leu Pro Gly Glu Arg 
                 165                170                175
His Arg Lys Arg Arg Arg Ser Leu Ser Phe Asp Pro Ser Leu Gly Leu 
             180                185                190
Cys Glu Leu Arg Glu Met Cys Ser Gly Gly Ser Ser Ser Ser Ser Ser 
         195                200                205
Ser Ser Ser Glu Ser Thr Glu Thr Pro Ser His Gln Asp Leu Asp Asp 
     210                215                220
Gly Val Ser Glu His Ser Gly Asp Cys Leu Asp Gln Asp Ser Val Ser 
 225                230                235                240
Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser Glu Asp 
                 245                250                255
Tyr Ser Leu Ser Asp Glu Gly His Glu Leu Ser Asp Glu Asp Asp Glu 
             260                265                270
Val Tyr Arg Val Thr Val Tyr Gln Thr Gly Glu Ser Asp Thr Asp Ser 
         275                280                285
Phe Glu Gly Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys Cys Thr 
     290                295                300
Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Lys Arg Cys 
 305                310                315                320
Trp Thr Leu Arg Glu Asn Trp Leu Pro Asp Asp Lys Gly Lys Asp Lys 
                 325                330                335
Val Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Ala Gln Ala Glu 
             340                345                350
Glu Gly Leu Asp Val Pro Asp Gly Lys Lys Leu Thr Glu Asn Asp Ala 
         355                360                365
Lys Glu Pro Cys Ala Glu Glu Asp Ser Glu Glu Lys Ala Glu Gln Thr 
     370                375                380
Pro Leu Ser Gln Glu Ser Asp Asp Tyr Ser Gln Pro Ser Thr Ser Ser 
 385                390                395                400
Ser Ile Val Tyr Ser Ser Gln Glu Ser Val Lys Glu Leu Lys Glu Glu 
                 405                410                415
Thr Gln Asp Lys Asp Glu Ser Val Glu Ser Ser Phe Ser Leu Asn Ala 
             420                425                430
Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly Cys Ile 
         435                440                445
Val His Gly Lys Thr Gly His Leu Met Ser Cys Phe Thr Cys Ala Lys 
     450                455                460
Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln Pro Ile 
 465                470                475                480
Gln Met Ile Val Leu Ser Tyr Phe Asn 
                 485



<210> 7481
<211> 2372
<212> DNA
<213> Homo sapiens
<308> NM_002392
<400> 7481

gcaccgcgc  agcttggct  cttctgggg  ctgtgtggc  ctgtgtgtc  gaaagatgg  60
gcaagaagc  gagcccgag  ggcggccgc  acccctctg  ccgagatcc  gctgctttc  120
cagccagga  caccgtccc  ccccggatt  gtgcgtacg  gcgcccagt  ccctggccc  180
gagagtgga  tgatccccg  ggcccaggg  gtcgtgctt  cgcagtagt  agtccccgt  240
aaggaaact  gggagtctt  agggacccc  gactccaag  gcgaaaacc  cggatggtg  300
ggagcaggc  aatgtgcaa  accaacatg  ctgtaccta  tgatggtgc  gtaaccacc  360
cacagattc  agcttcgga  caagagacc  tggttagac  aaagccatt  cttttgaag  420
tattaaagt  tgttggtgc  caaaaagac  cttatacta  gaaagaggt  cttttttat  480
ttggccagt  tattatgac  aaacgatta  atgatgaga  gcaacaaca  attgtatat  540
gttcaaatg  tcttctagg  gatttgttt  gcgtgccaa  cttctctgt  aaagagcac  600
ggaaaatat  taccatgat  tacaggaac  tggtagtag  caatcagca  gaatcatcg  660
actcaggta  atctgtgag  gagaacagg  gtcaccttg  aggtgggag  gatcaaaag  720
accttgtac  agagcttca  gaagagaaa  cttcatctt  acatttggt  tctagacca  780
ctacctcat  tagaaggag  gcaattagt  agacagaag  aaattcaga  gaattatct  840
gtgaacgac  aagaaaacg  cacaaatct  atagtattt  cctttcctt  gatgaaagc  900
tggctctgt  tgtaataag  gagatatgt  gtgaaagaa  cagtagcag  gaatctaca  960
ggacgccat  gaatccgga  cttgatgct  gtgtaagtg  acattcagg  gattggttg  1020
atcaggatt  agtttcaga  cagtttagt  tagaatttg  agttgaatc  ctcgactca  1080
aagattata  ccttagtga  gaaggacaa  aactctcag  tgaagatga  gaggtatat  1140
aagttactg  gtatcaggc  ggggagagt  atacagatt  atttgaaga  gatcctgaa  1200
tttccttag  tgactattg  aaatgcact  catgcaatg  aatgaatcc  ccccttcca  1260
cacattgca  cagatgttg  gcccttcgt  agaattggc  tcctgaaga  aaagggaaa  1320
ataaagggg  aatctctga  aaagccaaa  tggaaaact  aacacaagc  gaagagggc  1380
ttgatgttc  tgattgtaa  aaaactata  tgaatgatt  cagagagtc  tgtgttgag  1440
aaaatgatg  taaaattac  caagcttca  aatcacaag  aagtgaaga  tattctcag  1500
catcaactt  tagtagcat  atttatagc  gccaagaag  tgtgaaaga  tttgaaagg  1560
aagaaaccc  agacaaaga  gagagtgtg  aatctagtt  gccccttaa  gccattgaa  1620
cttgtgtga  ttgtcaagg  cgacctaaa  atggttgca  tgtccatgg  aaaacagga  1680
atcttatgg  ctgctttac  tgtgcaaag  agctaaaga  aaggaataa  ccctgccca  1740
tatgtagac  accaattca  atgattgtg  taacttatt  cccctagtt  acctgtcta  1800
aagagaatt  tatatttct  actatataa  cctaggaat  tagacaacc  gaaatttat  1860
cacatatat  aaagtgaga  aatgcctca  ttcacatag  tttcttctc  ttagtataa  1920
tgacctact  tggtagtgg  atagtgaat  cttactata  tttgacttg  atatgtagc  1980
catccttta  accaactcc  aattttaaa  aatttctac  ctgtcttaa  tgagaagta  2040
ttggttttt  ttttcttaa  tatgtatat  acatttaaa  gtaacttat  atttttttt  2100
agaccgagt  ttgctctgt  acccaggct  gagtgcagt  ggtgatctt  gctcactgc  2160
agctctgcc  tccccgggt  cgcaccatt  tcctgcctc  gcctcccaa  tagcttggc  2220
tacagtcat  tgccaccac  cctggctaa  tttttgtac  tttagtaga  acagggttt  2280
accgtgtta  ccaggatgg  ctcgatctc  tgacctcgt  atccgccca  ctcggcctc  2340
caaagtgct  ggattacag  catgagcca  cg  2372



<210> 7482
<211> 491
<212> PRT
<213> Homo sapiens
<308> Q9UMT8
<400> 7482

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
  1               5                  10                  15
Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
             20                  25                  30
Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
         35                  40                  45
Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys 
     50                  55                  60
Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp 
 65                  70                  75                  80
Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val Lys Glu His 
                 85                  90                  95
Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val Val Asn Gln 
             100                105                110
Gln Glu Ser Ser Asp Ser Gly Thr Ser Val Ser Glu Asn Arg Cys His 
         115                120                125
Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu Val Gln Glu Leu Gln Glu 
     130                135                140
Glu Lys Pro Ser Ser Ser His Leu Val Ser Arg Pro Ser Thr Ser Ser 
 145                150                155                160
Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu Asn Ser Asp Glu Leu Ser 
                 165                170                175
Gly Glu Arg Gln Arg Lys Arg His Lys Ser Asp Ser Ile Ser Leu Ser 
             180                185                190
Phe Asp Glu Ser Leu Ala Leu Cys Val Ile Arg Glu Ile Cys Cys Glu 
         195                200                205
Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr Pro Ser Asn Pro Asp Leu 
     210                215                220
Asp Ala Gly Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser 
 225                230                235                240
Val Ser Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser 
                 245                250                255
Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp 
             260                265                270
Asp Glu Val Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu Ser Asp Thr 
         275                280                285
Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys 
     290                295                300
Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn 
 305                310                315                320
Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys 
                 325                330                335
Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln 
             340                345                350
Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn 
         355                360                365
Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln 
     370                375                380
Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser 
 385                390                395                400
Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg 
                 405                410                415
Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu 
             420                425                430
Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly 
         435                440                445
Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys 
     450                455                460
Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln 
 465                470                475                480
Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
                 485                490



<210> 7483
<211> 408
<212> DNA
<213> Rattus norvegicus
<308> AI639490
<400> 7483

ttgctgtat  aaaactgta  ttttttctt  taatataaa  ctattgtca  tgccacaaa  60
tagaacaag  ttctgatta  tttacaaca  cgggcaggc  gccgagggg  aggagcagg  120
ggcggggga  gggattgtg  tggaagaag  gtccagacc  ggctctccc  tccctgccc  180
tgctggtcc  cagctcgat  tgccgcttt  ccatgaaat  ttgagtaca  atatatgtg  240
aaatgcccc  tagaacttg  gaaaagaaa  aaagtctta  aaaacagtc  aaaagtttt  300
ttcatttca  gcaaagatt  tagttgaag  gtttctggt  taaaaaaca  ccgggcttg  360
ttcgtatac  tttttgcat  gcaagaatc  tggatgggt  tccaggcc  408



<210> 7484
<211> 403
<212> DNA
<213> Rattus norvegicus
<308> AI639494
<400> 7484

ttgacggag  ccggttgca  ttagaacca  tcaattaac  cagctggac  acatagctg  60
tccctgata  aggggctgg  ggtacaact  agagctctc  aatctaaat  aagtgattc  120
atggacttg  ggatctccc  tcccttcac  agggcaggg  aatttcatc  tgaagagac  180
aaggggact  actactgta  tcacacccc  gtaccacat  acctcgggt  agtgacaga  240
gcgttcaca  cacgccttg  aaagttgac  gcagagccc  aatgaaggc  ctgactagg  300
ttgtgatga  tctactcca  aaaggtgca  gaagaggtc  cctagctac  ctacatcca  360
atgatacag  ctggggact  gccgggttt  tcggttctc  ata  403



<210> 7485
<211> 648
<212> PRT
<213> Rattus norvegicus
<308> P11345
<400> 7485

Met Glu His Ile Gln Gly Ala Trp Lys Thr Ile Ser Asn Gly Phe Gly 
  1               5                  10                  15
Leu Lys Asp Ala Val Phe Asp Gly Ser Ser Cys Ile Ser Pro Thr Ile 
             20                  25                  30
Val Gln Gln Phe Gly Tyr Gln Arg Arg Ala Ser Asp Asp Gly Lys Leu 
         35                  40                  45
Thr Asp Ser Ser Lys Thr Ser Asn Thr Ile Arg Val Phe Leu Pro Asn 
     50                  55                  60
Lys Gln Arg Thr Val Val Asn Val Arg Asn Gly Met Ser Leu His Asp 
 65                  70                  75                  80
Cys Leu Met Lys Ala Leu Lys Val Arg Gly Leu Gln Pro Glu Cys Cys 
                 85                  90                  95
Ala Val Phe Arg Leu Leu Gln Glu His Lys Gly Lys Lys Ala Arg Leu 
             100                105                110
Asp Trp Asn Thr Asp Ala Ala Ser Leu Ile Gly Glu Glu Leu Gln Val 
         115                120                125
Asp Phe Leu Asp His Val Pro Leu Thr Thr His Asn Phe Ala Arg Lys 
     130                135                140
Thr Phe Leu Lys Leu Ala Phe Cys Asp Ile Cys Gln Lys Phe Leu Leu 
 145                150                155                160
Asn Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Glu His Cys 
                 165                170                175
Ser Thr Lys Val Pro Thr Met Cys Val Asp Trp Ser Asn Ile Arg Gln 
             180                185                190
Leu Leu Leu Phe Pro Asn Ser Thr Ala Ser Asp Ser Gly Val Pro Ala 
         195                200                205
Pro Pro Ser Phe Thr Met Arg Arg Met Arg Glu Ser Val Ser Arg Met 
     210                215                220
Pro Ala Ser Ser Gln His Arg Tyr Ser Thr Pro His Ala Phe Thr Phe 
 225                230                235                240
Asn Thr Ser Ser Pro Ser Ser Glu Gly Ser Leu Ser Gln Arg Gln Arg 
                 245                250                255
Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr Leu Pro Val 
             260                265                270
Asp Ser Arg Met Ile Glu Asp Ala Ile Arg Ser His Ser Glu Ser Ala 
         275                280                285
Ser Pro Ser Ala Leu Ser Ser Ser Pro Asn Asn Leu Ser Pro Thr Gly 
     290                295                300
Trp Ser Gln Pro Lys Thr Pro Val Pro Ala Gln Arg Glu Arg Ala Pro 
 305                310                315                320
Gly Ser Gly Thr Gln Glu Lys Asn Lys Ile Arg Pro Arg Gly Gln Arg 
                 325                330                335
Asp Ser Ser Tyr Tyr Trp Glu Ile Glu Ala Ser Glu Val Met Leu Ser 
             340                345                350
Thr Arg Ile Gly Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp 
         355                360                365
His Gly Asp Val Ala Val Lys Ile Leu Lys Val Val Asp Pro Thr Pro 
     370                375                380
Glu Gln Leu Gln Ala Phe Arg Asn Glu Val Ala Val Leu Arg Lys Thr 
 385                390                395                400
Arg His Val Asn Ile Leu Leu Phe Met Gly Tyr Met Thr Lys Asp Asn 
                 405                410                415
Leu Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr Lys His 
             420                425                430
Leu His Val Gln Glu Thr Lys Phe Gln Met Phe Gln Leu Ile Asp Ile 
         435                440                445
Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His Ala Lys Asn Ile 
     450                455                460
Ile His Arg Asp Met Lys Ser Asn Asn Ile Phe Leu His Glu Gly Leu 
 465                470                475                480
Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp 
                 485                490                495
Ser Gly Ser Gln Gln Val Glu Gln Pro Thr Gly Ser Val Leu Trp Met 
             500                505                510
Ala Pro Glu Val Ile Arg Met Gln Asp Asn Asn Pro Phe Ser Phe Gln 
         515                520                525
Ser Asp Val Tyr Ser Tyr Gly Ile Val Leu Tyr Glu Leu Met Thr Gly 
     530                535                540
Glu Leu Pro Tyr Ser His Ile Asn Asn Arg Asp Gln Ile Ile Phe Met 
 545                550                555                560
Val Gly Arg Gly Tyr Ala Ser Pro Asp Leu Ser Arg Leu Tyr Lys Asn 
                 565                570                575
Cys Pro Lys Ala Met Lys Arg Leu Val Ala Asp Cys Val Lys Lys Val 
             580                585                590
Lys Glu Glu Arg Pro Leu Phe Pro Gln Ile Leu Ser Ser Ile Glu Leu 
         595                600                605
Leu Gln His Ser Leu Pro Lys Ile Asn Arg Ser Ala Ser Glu Pro Ser 
     610                615                620
Leu His Arg Ala Ala His Thr Glu Asp Ile Asn Ala Cys Thr Leu Thr 
 625                630                635                640
Thr Ser Pro Arg Leu Pro Val Phe 
                 645



<210> 7486
<211> 2602
<212> DNA
<213> Homo sapiens
<308> X06409
<400> 7486

gcggtcagg  atcatgagg  agagtgcgt  ggagccggg  cctgtgccc  aggcgccgg  60
ggggggtcc  gtgcacgcc  tgacggtgg  gaccctgct  gagaagctg  cctccatgc  120
ggagactct  cgggagcgg  agggaggcc  ggctcgaag  cagggaggc  tggcagggt  180
cgtgcgccg  atccagagc  gcctgggcg  tctgagtcg  agccacgac  ccaccagca  240
caccttggc  cagctgctg  ccaaggcgg  gcgcgtgag  tcgcacgcc  acgccgccc  300
agagcgcgc  gtgcgccgc  cagcccagg  gcagcggct  gaggccaac  acgggctgc  360
ggtggcgcg  gggaagctc  acgttctgc  cttcaagga  gagggtgaa  tcccagcca  420
cgctttcca  aaggcacca  agcccttgg  cccggcgga  cagtccgag  tgggcccag  480
gcagctgga  gccgaagtt  gagagagct  ggacgagga  ccggtggag  ccagggccc  540
gcggctgcg  cgcaccgga  tgcagaagg  tgcaattcg  agtcacagc  aatcagcct  600
accttcagc  ctgtccagt  gccccaaca  tctgagccc  acaggctgg  cacagccga  660
aacccccgt  ccagcacaa  gagagcggg  accagtatc  gggacccag  agaaaaaca  720
aattaggcc  cgtggacag  gagattcaa  ctattattg  gaaatagaa  ccagtgaag  780
gatgctgtc  actcggatt  ggtcaggct  ttttggaac  gtttataag  gtaaatggc  840
cggagatgt  gcagtaaag  tcctaaagg  tgtcgaccc  accccagag  aattccagg  900
cttcaggaa  gaggtggct  ttctgcgca  aacacggca  gtgaacatt  tgcttttca  960
ggggtacat  acaaaggac  acctggcaa  tgtgaccca  tggtgcgag  gcagcagcc  1020
ctacaaaca  ctgcatgtc  aggagacca  gtttcagat  ttccagcta  ttgacattg  1080
ccggcagac  gctcaggga  tggactatt  gcatgcaaa  aacatcatc  atagagaca  1140
gaaatccaa  aatatattt  tccatgaag  cttaacagt  aaaattgga  attttggtt  1200
ggcaacagt  aagtcacgc  ggagtggtt  tcagcaggt  gaacaacct  ctggctctg  1260
cctctggat  gccccagag  tgatccgaa  gcaggataa  aacccattc  gtttccagt  1320
ggatgtcta  tcctatggc  tcgtattgt  tgaactgat  acgggggag  ttccttatt  1380
tcacatcaa  aaccgagat  agatcatct  catggtggg  cgaggatat  cctccccag  1440
tcttagtaa  ctatataag  actgcccca  agcaatgaa  aggctggta  ctgactgtg  1500
gaagaaagt  aaggaagag  ggcctcttt  tccccagat  ctgtcttcc  ttgagctgc  1560
ccaacactc  ctaccgaag  tcaaccgga  cgcttccga  ccatccttg  atcgggcag  1620
ccacactga  gatatcaat  cttgcacgc  gaccacgtc  ccgaggctg  ctgtcttct  1680
gttgacttt  cacctgtct  caggctgcc  ggggaggag  agaagccag  aggcaccac  1740
tttctgctc  ctttctcca  aggcagaac  catgttttc  gagaagctg  tgctaagga  1800
cttctagac  gctcacagg  ccttaactt  atgttgcct  cttttctat  cctttgggc  1860
ctgggagaa  gaagccatt  gcagtgctg  tgtgtcctg  tccctcccc  cattcccca  1920
gctcaaggc  cagccttct  tagatgcgc  agtggatgt  gatggtagt  caaaaagca  1980
gggcccagc  ccagctgtt  gctacatga  tatttagag  aagtaaggt  gcaggcagt  2040
cagccctga  gtggagaca  atgggattt  ggaaatcag  ttctggagg  atgcatgtc  2100
caggcggga  tttcttcag  gagtggtgc  gcgccagac  ttttgcaca  aaggcacca  2160
acagcccag  actgccgag  ctctggccg  ccgaaggag  ctgctttgg  actatggaa  2220
ttttcttag  ggacacgtc  tcctttcac  gcttctaag  tgtccagtg  attgggatg  2280
ttttccagg  aaggcactc  gccaatccg  atctcagcc  tctcaggga  cagtcttcc  2340
tcatgctga  ttttgtctt  caggagctg  ccctatggg  cggggccgc  gggccagcc  2400
tgtttctct  acaaacaaa  aaacaaaca  ccttgtttc  ctagtcaca  catgtgtat  2460
caaggaagc  aggaataca  gttttcttg  tgatttggg  tttaatttt  tttttattg  2520
acctgacaa  atacagtta  ctgatggtc  ctcaattat  ttattttaa  aaaataaat  2580
aaatttaaa  aaaaaaaaa  aa  2602



<210> 7487
<211> 648
<212> PRT
<213> Homo sapiens
<308> P04049
<400> 7487

Met Glu His Ile Gln Gly Ala Trp Lys Thr Ile Ser Asn Gly Phe Gly 
  1               5                  10                  15
Phe Lys Asp Ala Val Phe Asp Gly Ser Ser Cys Ile Ser Pro Thr Ile 
             20                  25                  30
Val Gln Gln Phe Gly Tyr Gln Arg Arg Ala Ser Asp Asp Gly Lys Leu 
         35                  40                  45
Thr Asp Pro Ser Lys Thr Ser Asn Thr Ile Arg Val Phe Leu Pro Asn 
     50                  55                  60
Lys Gln Arg Thr Val Val Asn Val Arg Asn Gly Met Ser Leu His Asp 
 65                  70                  75                  80
Cys Leu Met Lys Ala Leu Lys Val Arg Gly Leu Gln Pro Glu Cys Cys 
                 85                  90                  95
Ala Val Phe Arg Leu Leu His Glu His Lys Gly Lys Lys Ala Arg Leu 
             100                105                110
Asp Trp Asn Thr Asp Ala Ala Ser Leu Ile Gly Glu Glu Leu Gln Val 
         115                120                125
Asp Phe Leu Asp His Val Pro Leu Thr Thr His Asn Phe Ala Arg Lys 
     130                135                140
Thr Phe Leu Lys Leu Ala Phe Cys Asp Ile Cys Gln Lys Phe Leu Leu 
 145                150                155                160
Asn Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Glu His Cys 
                 165                170                175
Ser Thr Lys Val Pro Thr Met Cys Val Asp Trp Ser Asn Ile Arg Gln 
             180                185                190
Leu Leu Leu Phe Pro Asn Ser Thr Ile Gly Asp Ser Gly Val Pro Ala 
         195                200                205
Leu Pro Ser Leu Thr Met Arg Arg Met Arg Glu Ser Val Ser Arg Met 
     210                215                220
Pro Val Ser Ser Gln His Arg Tyr Ser Thr Pro His Ala Phe Thr Phe 
 225                230                235                240
Asn Thr Ser Ser Pro Ser Ser Glu Gly Ser Leu Ser Gln Arg Gln Arg 
                 245                250                255
Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr Leu Pro Val 
             260                265                270
Asp Ser Arg Met Ile Glu Asp Ala Ile Arg Ser His Ser Glu Ser Ala 
         275                280                285
Ser Pro Ser Ala Leu Ser Ser Ser Pro Asn Asn Leu Ser Pro Thr Gly 
     290                295                300
Trp Ser Gln Pro Lys Thr Pro Val Pro Ala Gln Arg Glu Arg Ala Pro 
 305                310                315                320
Val Ser Gly Thr Gln Glu Lys Asn Lys Ile Arg Pro Arg Gly Gln Arg 
                 325                330                335
Asp Ser Ser Tyr Tyr Trp Glu Ile Glu Ala Ser Glu Val Met Leu Ser 
             340                345                350
Thr Arg Ile Gly Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp 
         355                360                365
His Gly Asp Val Ala Val Lys Ile Leu Lys Val Val Asp Pro Thr Pro 
     370                375                380
Glu Gln Phe Gln Ala Phe Arg Asn Glu Val Ala Val Leu Arg Lys Thr 
 385                390                395                400
Arg His Val Asn Ile Leu Leu Phe Met Gly Tyr Met Thr Lys Asp Asn 
                 405                410                415
Leu Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr Lys His 
             420                425                430
Leu His Val Gln Glu Thr Lys Phe Gln Met Phe Gln Leu Ile Asp Ile 
         435                440                445
Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His Ala Lys Asn Ile 
     450                455                460
Ile His Arg Asp Met Lys Ser Asn Asn Ile Phe Leu His Glu Gly Leu 
 465                470                475                480
Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp 
                 485                490                495
Ser Gly Ser Gln Gln Val Glu Gln Pro Thr Gly Ser Val Leu Trp Met 
             500                505                510
Ala Pro Glu Val Ile Arg Met Gln Asp Asn Asn Pro Phe Ser Phe Gln 
         515                520                525
Ser Asp Val Tyr Ser Tyr Gly Ile Val Leu Tyr Glu Leu Met Thr Gly 
     530                535                540
Glu Leu Pro Tyr Ser His Ile Asn Asn Arg Asp Gln Ile Ile Phe Met 
 545                550                555                560
Val Gly Arg Gly Tyr Ala Ser Pro Asp Leu Ser Lys Leu Tyr Lys Asn 
                 565                570                575
Cys Pro Lys Ala Met Lys Arg Leu Val Ala Asp Cys Val Lys Lys Val 
             580                585                590
Lys Glu Glu Arg Pro Leu Phe Pro Gln Ile Leu Ser Ser Ile Glu Leu 
         595                600                605
Leu Gln His Ser Leu Pro Lys Ile Asn Arg Ser Ala Ser Glu Pro Ser 
     610                615                620
Leu His Arg Ala Ala His Thr Glu Asp Ile Asn Ala Cys Thr Leu Thr 
 625                630                635                640
Thr Ser Pro Arg Leu Pro Val Phe 
                 645



<210> 7488
<211> 370
<212> DNA
<213> Rattus norvegicus
<308> AI639499
<400> 7488

ttaacagtt  tgactggtt  actttaatt  gtcaaaata  atctgcagt  ttttgcatg  60
tagtaatac  gtgctggta  tgacaggta  aatcatcat  tgcgtacat  gaaaccttc  120
tttaggagc  caccttagg  gggaaatga  tacacagta  aaggtagat  caggccaag  180
agcgagccc  agagcaagc  gaacaggct  gatgtcaga  ttgaagatt  tctaataca  240
ctgtttagc  gccaatctg  taaagggaa  gctctccgc  gggttacaa  caggaggga  300
aacatactc  gccttttgt  gagtggtgg  cgtcggtgc  ttcgacaca  ggttgaatc  360
gttcatcagt  370



<210> 7489
<211> 486
<212> DNA
<213> Rattus norvegicus
<308> AI639501
<400> 7489

ttccacata  ataacttta  gttaactac  aaaatcatg  aatgaagaa  agatcatgg  60
actgcacac  caagcatca  tggagtgac  cacaggttt  cccagatga  tgctaagag  120
gaaaaaagg  accaggata  aacaaactc  tatttaagt  gtaaacatg  cagatattt  180
aaaataata  atacagaat  gcaggagag  aactaaaat  ataaaacag  atggagtat  240
ttttatttt  tttaagaca  atgaaattt  taggcacag  tttaggcat  aaggaggac  300
cagaggcat  ggttagtgt  tgctgctct  tacaaaaat  cagtctgaa  aaattacat  360
gctagccat  caattagac  atcacttat  agtcaattc  ctgcatgtt  aataatata  420
aggtacatg  gaatccata  atatcattt  tatttcaaa  acataagnc  ctctatatt  480
ggtttt  486



<210> 7490
<211> 3803
<212> DNA
<213> Homo sapiens
<308> NM_031442
<400> 7490

cgcccagga  tggcttcgg  gggcagcgg  atggaggag  tgcgcgtgt  ggtgctgac  60
cccttgaag  tggtcgggc  ggtgtgcat  ttcctggcg  tgtgtctgg  cctgggggc  120
gtgctgagc  cggcctggg  cacagctga  caccagtac  acctgtcgt  gtgggagtc  180
tgccgcaaa  ccgccagct  ggacatctg  cactgcgag  ccacgctca  cagcgattg  240
cagattgct  ctctggctt  actcctggg  ggcgctgcc  tcattctca  tgcattcct  300
gtgggtttg  tttctatct  cgtgggatc  cgaaggcgt  tctatagac  tgttgcggt  360
atgcttttt  cagcagttg  tttacaggt  tgcagcctg  tcctttacc  aatcaagtt  420
attgaaact  tgagcttga  aatttacca  gagttcaac  ggggttatg  cctggcctg  480
ggtgcaact  tattttcgt  tgggggtgc  atcctttat  gcctgaacc  taagaacta  540
gaagactac  actagaacc  atagtctca  agtaaaaac  accaccacc  tccaacaaa  600
ggattacgt  tgcatcttt  ctaacttac  attttctaa  acacttgtg  agcatcaag  660
agtttgctc  gttgattta  tcttttttg  cttttggct  tcaatatca  aaccagctt  720
tacatccat  ttagaaatc  gcacaaatt  agagagctg  ttagacata  gcaaatgct  780
caaacttcc  atatgttca  atcgttttt  ttgacaaat  aagggtcta  atgacagca  840
ccattgtga  aaactagtt  gaatgagat  tgcctcaat  tcctattgc  tgcagggga  900
cagttggca  aagcaacat  tagaagttc  tttgcgctg  caaggattc  actgttaga  960
cccttaccg  ctgcttatc  tacccaatg  ctacattgg  tgttggtta  ttgcttgag  1020
gagcccttg  aaaatgaac  gcccttcag  atctaatgg  agttgtgaa  gtaactggt  1080
aatgataca  attccacct  caggaacac  ctttttaat  ggaggttat  ctttggcaa  1140
cagcgtctc  ctgggaaga  agtcaagac  tggagacat  tgcttctca  tatgtggtt  1200
gaaattggt  cctcagccc  atctagact  gggaaaaat  gaggatctc  gtttttcct  1260
gggcaaaca  aaagaaatc  gcatgagtt  cttttgtac  ctttaaatc  tttgccaaa  1320
attgcagca  acaagtgtg  gtatgtaac  agcttcact  tttttatag  aggtgaacc  1380
ttagtataa  tggtaataa  ttgttccct  accctccac  tacatttgc  tatcacacg  1440
aaaattaat  tttactcta  tgaagtggt  tgagcacta  ccttgtaca  attgttaag  1500
ggcttagat  ggtattcat  cttatttac  atacaaaag  atggtacct  aaagctttt  1560
ctctatgtt  tttactgtt  cactggaaa  tgtcaatag  gttgcctaa  aataaaaat  1620
gaaatggtg  taatctgaa  attaatgat  ctctgtaag  actgtagtt  aaaagagag  1680
agcaattag  atgatcatt  tgtgtaaaa  tcattaaaa  agaaggctg  tattttttg  1740
aagtatttt  aatgtcttc  tttttttaa  aaaggaata  cgatagatt  atataaata  1800
ctaaatgtc  cagtagagg  gtagaattc  tctggttat  acctggtcc  ctgaagtta  1860
ctgatgggc  aaccgattt  tgcacacac  taggatgga  ttatgttaa  ggaattact  1920
actgactgt  caatggaag  aagtattaa  aatagggaa  aagtttgca  ctaatctca  1980
gctgcaaac  tgtgttaat  ctgtttaat  tacaaattt  gatagctta  ttataaaca  2040
atttttata  caaatatac  gttctaata  aaaagttat  aataattat  tttgttaac  2100
aagacacta  aacagtatg  tctggtttt  gccctcttg  agaaagaag  attagaaaa  2160
ttactttaa  agtagctat  tgttactgt  ttgcaaaat  tgttaagag  aggaccaca  2220
cgatagtat  taataattt  ttttacctc  caaaacaca  ttcttcttt  agcttgtct  2280
aagaatggt  gccaaaaac  acagccaaa  aaaaaaaaa  ctattttat  atccaaatg  2340
tagaaaaca  acatgaatt  tctataaaa  cacgaatat  aagtaccag  tttagtctt  2400
ctttagcaa  gatagacaa  agcgaataa  tacatcaca  acagaaacc  ttataaaaa  2460
atatgattc  ataaagaat  attagaaat  atgagtgga  attctccag  aagatagta  2520
tatagagtc  tttgaagca  ttttttgag  aatagtaaa  tctggggca  agtgtcttg  2580
agttaattg  atattgtca  agcagcatg  gaaatatga  atttggata  ggatttcag  2640
aactaaaca  tctctgttc  gagatctct  tattcctga  taatgaaag  atagtactt  2700
ggtgctgac  ccaatgagg  acttctctt  gtcctagta  aggatgcag  gtactgtta  2760
accaatatc  tcacatctc  agtcttatc  agttttcat  ctctgtcaa  atgacaagc  2820
caaagtgac  gaatatgtt  taggttgaa  cacacatat  tgcagttta  tgaaaagta  2880
atttcttat  tgacttttt  cccttctca  caaagagcc  tacactaga  ttctaccat  2940
actaatatt  ggaagtatt  cattactaa  aatctcagt  caacatgaa  attgttgct  3000
ctcatctaa  atacaattt  gtctatcag  ataaacaca  gtgaaattt  cacctacat  3060
aacattatg  ctttgcagc  ttaggtttg  tagatgtgt  cttaagcat  atttttagc  3120
acaaaccca  tgttagata  atatctatg  atatagatc  acatctata  atatagata  3180
acacacata  atatactca  acacatata  cataaaata  tcagcaggg  tagttattc  3240
gatttcttg  acaattatt  agctttttg  aagttcaac  tgtaaattt  aaagacata  3300
atatagaga  acttatgtg  ttgaatata  atgatatat  tggattagc  tgtacctgt  3360
tattattaa  catgcaatg  actgactgg  aagtgacgt  taattgtat  gctagcaat  3420
taatttatt  agactgtat  tttgtacag  gcagtgcac  ctaacctat  cctctgtgt  3480
ctctttaat  cctaaagct  tgcctagaa  tttcatctg  cttaaaagt  aaatatact  3540
catgctgtt  atgctatta  tttctgtac  gctattcta  atttattat  tttaaatat  3600
tgacatgtt  actacttaa  catgaattc  tggtatcct  gttattttt  ttaagtcat  3660
tgggggaaa  cctgtttat  actccagtg  ttttgagtt  gcagtttca  aatcagttc  3720
tcatttcat  atttttgta  ttgacatga  gtcatctat  tggaaaaaa  taaaaataa  3780
agtgaaaaa  aaaaaaaaa  aaa  3803



<210> 7491
<211> 181
<212> PRT
<213> Homo sapiens
<308> NP_113630
<400> 7491

Met Ala Ser Ala Gly Ser Gly Met Glu Glu Val Arg Val Ser Val Leu 
  1               5                  10                  15
Thr Pro Leu Lys Leu Val Gly Leu Val Cys Ile Phe Leu Ala Leu Cys 
             20                  25                  30
Leu Asp Leu Gly Ala Val Leu Ser Pro Ala Trp Val Thr Ala Asp His 
         35                  40                  45
Gln Tyr Tyr Leu Ser Leu Trp Glu Ser Cys Arg Lys Pro Ala Ser Leu 
     50                  55                  60
Asp Ile Trp His Cys Glu Ser Thr Leu Ser Ser Asp Trp Gln Ile Ala 
 65                  70                  75                  80
Thr Leu Ala Leu Leu Leu Gly Gly Ala Ala Ile Ile Leu Ile Ala Phe 
                 85                  90                  95
Leu Val Gly Leu Ile Ser Ile Cys Val Gly Ser Arg Arg Arg Phe Tyr 
             100                105                110
Arg Pro Val Ala Val Met Leu Phe Ala Ala Val Val Leu Gln Val Cys 
         115                120                125
Ser Leu Val Leu Tyr Pro Ile Lys Phe Ile Glu Thr Val Ser Leu Lys 
     130                135                140
Ile Tyr His Glu Phe Asn Trp Gly Tyr Gly Leu Ala Trp Gly Ala Thr 
 145                150                155                160
Ile Phe Ser Phe Gly Gly Ala Ile Leu Tyr Cys Leu Asn Pro Lys Asn 
                 165                170                175
Tyr Glu Asp Tyr Tyr 
             180



<210> 7492
<211> 543
<212> DNA
<213> Rattus norvegicus
<308> AI639504
<400> 7492

ttagagagc  tcagccgtt  tatttcttg  atgatcatt  gcatgaagg  aaagtccaa  60
acaggggct  tgcattctg  ggattgcgg  ccaagtgtt  taagctcct  atagcactt  120
gcctgggtt  atgagacct  ggggatcca  tgtgtcttt  agttgcctc  tggtctcca  180
acccacagg  cccacttcc  cttgaagca  ctgcctctt  cccagaccg  tgccatgtt  240
tccagtaca  gtcccatgg  gtgccaggg  acgcctgcc  agattttct  caaaggcct  300
gaccctcct  tgctcctcc  catcatctg  gttgaccaa  aggatgcag  gaaagttgc  360
gtcacccac  tgcccaaca  tgactcctg  gagttttga  gccttaagc  cctccttgg  420
ctctaccaa  atctctggc  accgggaga  gggcacaca  acgtccgtg  aataggcct  480
acttcctgg  cgcagggcc  aagctgcat  ccaagcatt  tgccgtgca  cccaaagtt  540
att  543



<210> 7493
<211> 266
<212> DNA
<213> Homo sapiens
<308> BI517972
<400> 7493

atggtctcc  cgcccacgg  gcccacctc  tcctgcagc  gctgccgct  gcccattcc  60
atgccatgc  cccccgtgc  cgttccgtg  agagccagt  cccgcctgc  cagctgttc  120
gcaaaagcc  tgaccctgc  cagttcctc  gcgtcatca  ggttgacca  caggatgca  180
tggaagttg  cgtcaccca  atgcccgac  atgcttcct  tgagtcctg  ggcattcag  240
tcctccttg  tctgcacca  gatctc  266



<210> 7494
<211> 489
<212> PRT
<213> Homo sapiens
<308> Q9BR76
<400> 7494

Met Ser Phe Arg Lys Val Val Arg Gln Ser Lys Phe Arg His Val Phe 
  1               5                  10                  15
Gly Gln Pro Val Lys Asn Asp Gln Cys Tyr Glu Asp Ile Arg Val Ser 
             20                  25                  30
Arg Val Thr Trp Asp Ser Thr Phe Cys Ala Val Asn Pro Lys Phe Leu 
         35                  40                  45
Ala Val Ile Val Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro 
     50                  55                  60
Leu Ser Lys Thr Gly Arg Ile Asp Lys Ala Tyr Pro Thr Val Cys Gly 
 65                  70                  75                  80
His Thr Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Glu 
                 85                  90                  95
Val Ile Ala Ser Gly Ser Glu Asp Cys Thr Val Met Val Trp Gln Ile 
             100                105                110
Pro Glu Asn Gly Leu Thr Ser Pro Leu Thr Glu Pro Val Val Val Leu 
         115                120                125
Glu Gly His Thr Lys Arg Val Gly Ile Ile Ala Trp His Pro Thr Ala 
     130                135                140
Arg Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Val Leu Ile Trp 
 145                150                155                160
Asn Val Gly Thr Ala Glu Glu Leu Tyr Arg Leu Asp Ser Leu His Pro 
                 165                170                175
Asp Leu Ile Tyr Asn Val Ser Trp Asn His Asn Gly Ser Leu Phe Cys 
             180                185                190
Ser Ala Cys Lys Asp Lys Ser Val Arg Ile Ile Asp Pro Arg Arg Gly 
         195                200                205
Thr Leu Val Ala Glu Arg Glu Lys Ala His Glu Gly Ala Arg Pro Met 
     210                215                220
Arg Ala Ile Phe Leu Ala Asp Gly Lys Val Phe Thr Thr Gly Phe Ser 
 225                230                235                240
Arg Met Ser Glu Arg Gln Leu Ala Leu Trp Asp Pro Glu Asn Leu Glu 
                 245                250                255
Glu Pro Met Ala Leu Gln Glu Leu Asp Ser Ser Asn Gly Ala Leu Leu 
             260                265                270
Pro Phe Tyr Asp Pro Asp Thr Ser Val Val Tyr Val Cys Gly Lys Gly 
         275                280                285
Asp Ser Ser Ile Arg Tyr Phe Glu Ile Thr Glu Glu Pro Pro Tyr Ile 
     290                295                300
His Phe Leu Asn Thr Phe Thr Ser Lys Glu Pro Gln Arg Gly Met Gly 
 305                310                315                320
Ser Met Pro Lys Arg Gly Leu Glu Val Ser Lys Cys Glu Ile Ala Arg 
                 325                330                335
Phe Tyr Lys Leu His Glu Arg Lys Cys Glu Pro Ile Val Met Thr Val 
             340                345                350
Pro Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr Pro Asp Thr Ala 
         355                360                365
Gly Pro Glu Ala Ala Leu Glu Ala Glu Glu Trp Val Ser Gly Arg Asp 
     370                375                380
Ala Asp Pro Ile Leu Ile Ser Leu Arg Glu Ala Tyr Val Pro Ser Lys 
 385                390                395                400
Gln Arg Asp Leu Lys Ile Ser Arg Arg Asn Val Leu Ser Asp Ser Arg 
                 405                410                415
Pro Ala Met Ala Pro Gly Ser Ser His Leu Gly Ala Pro Ala Ser Thr 
             420                425                430
Thr Thr Ala Ala Asp Ala Thr Pro Ser Gly Ser Leu Ala Arg Ala Gly 
         435                440                445
Glu Ala Gly Lys Leu Glu Glu Val Met Gln Glu Leu Arg Ala Leu Arg 
     450                455                460
Ala Leu Val Lys Glu Gln Gly Asp Arg Ile Cys Arg Leu Glu Glu Gln 
 465                470                475                480
Leu Gly Arg Met Glu Asn Gly Asp Ala 
                 485



<210> 7495
<211> 382
<212> DNA
<213> Rattus norvegicus
<308> AI639516
<400> 7495

ttaaacaga  gtaaacttt  tttggaatt  tggccccca  atttggtaa  aaacatttt  60
tggcaaaat  tcgttttaa  gttaaaggg  caaaaacaa  ccccaattt  tactttttt  120
gaagggaag  ttttttaag  ccccattag  gggaaaatt  tttgggttt  aaattttaa  180
aaaaaggat  ttagcaaag  gggggcaaa  ttttcgggg  ggggttttg  ttaagctcc  240
ttttaaaaa  atccgggga  aaaggggaa  aaccccatt  aacatccgg  attaaaccc  300
taagggggg  gggaatttt  tccggccaa  ctttaattt  acagatagg  gcatttaaa  360
cctgccctt  aaaagtact  tt  382



<210> 7496
<211> 437
<212> DNA
<213> Rattus norvegicus
<308> AI639518
<400> 7496

ttgggagaa  agtctgaaa  agtaaactt  aattaaaaa  aaataataa  aatacaact  60
caggttcgt  ctaggctct  ccacttggc  ttttacaga  tggtcggtt  tccactgaa  120
tcggagaag  tgaagatgt  ccacagagg  cacagagca  catcacttc  acaggcaaa  180
agctcgtgc  caggcttga  caatgtccg  ggctcgagt  actaagcgg  aaggctggt  240
tcccggaag  tcaaaacgc  agcttcttc  tcagcaggt  gactcggga  tccacctca  300
atccatgca  gttgttggc  tccccctga  gcctcatga  gaggccgcc  taggacaca  360
acgcagaga  acgtgtggc  gcttccgtt  aggtctcgt  cccttcgat  ctgtacact  420
tcccataca  tacatac  437



<210> 7497
<211> 83
<212> PRT
<213> Rattus norvegicus
<308> AAD19908
<400> 7497

Met Ala Gly Ile Leu Phe Glu Asp Ile Phe Asp Val Lys Asp Ile Asp 
  1               5                  10                  15
Pro Glu Gly Lys Lys Phe Asp Arg Val Ser Arg Leu His Cys Glu Ser 
             20                  25                  30
Glu Ser Phe Lys Met Asp Leu Ile Leu Asp Val Asn Ile Gln Ile Tyr 
         35                  40                  45
Pro Val Asp Leu Gly Asp Lys Phe Arg Leu Val Ile Ala Ser Thr Leu 
     50                  55                  60
Tyr Glu Asp Gly Thr Leu Asp Asp Gly Glu Tyr Asn Pro Thr Asp Asp 
 65                  70                  75                  80
Arg Pro Ser 
                 85



<210> 7498
<211> 812
<212> DNA
<213> Homo sapiens
<308> Z49199
<400> 7498

gtccacgct  gggggtgca  gtactccca  ctgtggtcg  gctctcacc  cttctgctg  60
tctcgtggc  ccctcgcga  ggcgggcat  ctgtttgag  atattttcg  tgtgaagga  120
attgacccg  agggcaaga  gtttgaccg  gtgtctcga  tgcattgtg  gagtgaatc  180
ttcaagatg  atctaatct  agatgtaaa  attcaaatt  accctgtag  cttgggtga  240
aagttccgg  tggtcatag  tagtacctt  tatgaagat  gtaccctgg  tgatggtga  300
tacaacccc  ctgatgata  gccttccag  gctgaccag  ttgagtatg  aatgtatgg  360
aaagtgtac  ggattgagg  agatgaaac  tctactgaa  cagcaacac  cctctctgc  420
tacgtgtcc  atgggggcc  gctcatgag  ctgcagggg  atgccaaca  cctgcatgg  480
ttcgaggtg  actccagag  ttatctcct  atgaagaag  tagccttct  aacctcgcc  540
gaagccagc  tctctgcca  gtcactcag  tcatgggca  tgttcaagc  tgagtggca  600
ccgctcttg  tcacctgtt  aggaagggc  ggctcactg  ccaccgtgg  ggcatcttt  660
actggcctc  actcaatgg  aaactgact  gcctgtgaa  gacacagtg  gagagctga  720
aatgaatca  aagctttat  tatatgatt  ttaaattaa  ctttacttt  tcagactgc  780
cctcccctt  ttgtaaaaa  tccatttac  gt  812



<210> 7499
<211> 150
<212> PRT
<213> Homo sapiens
<308> P52434
<400> 7499

Met Ala Gly Ile Leu Phe Glu Asp Ile Phe Asp Val Lys Asp Ile Asp 
  1               5                  10                  15
Pro Glu Gly Lys Lys Phe Asp Arg Val Ser Arg Leu His Cys Glu Ser 
             20                  25                  30
Glu Ser Phe Lys Met Asp Leu Ile Leu Asp Val Asn Ile Gln Ile Tyr 
         35                  40                  45
Pro Val Asp Leu Gly Asp Lys Phe Arg Leu Val Ile Ala Ser Thr Leu 
     50                  55                  60
Tyr Glu Asp Gly Thr Leu Asp Asp Gly Glu Tyr Asn Pro Thr Asp Asp 
 65                  70                  75                  80
Arg Pro Ser Arg Ala Asp Gln Phe Glu Tyr Val Met Tyr Gly Lys Val 
                 85                  90                  95
Tyr Arg Ile Glu Gly Asp Glu Thr Ser Thr Glu Ala Ala Thr Arg Leu 
             100                105                110
Ser Ala Tyr Val Ser Tyr Gly Gly Leu Leu Met Arg Leu Gln Gly Asp 
         115                120                125
Ala Asn Asn Leu His Gly Phe Glu Val Asp Ser Arg Val Tyr Leu Leu 
     130                135                140
Met Lys Lys Leu Ala Phe 
 145                150



<210> 7500
<211> 406
<212> DNA
<213> Rattus norvegicus
<308> AI639520
<400> 7500

ttgcttatt  accaaattt  tttttgaac  taaagaaca  cagattatg  caaattaaa  60
acaaagcac  aaaagtcgc  acacgttag  acctgagcg  agactgaag  caaatattc  120
cataataaa  ccacatcat  atgctgaaa  acaggtaaa  acattcaca  tactccacg  180
agtagaata  gtagcactt  cccccaaat  acaaccagt  aaatgtaac  gtgttaatt  240
cacgatacc  aaaatacac  ggaaactac  cgcacgtgt  ttcagtgcc  tgcacgtgg  300
acaccgcac  ggggaacag  atgcaggct  agagaggga  agccgtgct  aggctgttc  360
cagcggtca  ttcaggaca  gctccctgc  cggcgcatt  gtacta  406



<210> 7501
<211> 270
<212> DNA
<213> Homo sapiens
<308> AI919101
<400> 7501

gcgtattca  ccaaattta  ttttgaaca  tcagaacac  agattatca  agattaaaa  60
gaaagcacc  aaaattact  cacattaat  cctgagcag  gactgaagg  aaatattca  120
ctattaaac  tacaccata  tgctcaaac  caggtaaaa  cattcacaa  acactctac  180
gaatatagt  agtagtact  tttgtgaat  acaatcaca  aaatgtaat  attntaatt  240
taccatata  aaatacaca  aaaattacac  270



<210> 7502
<211> 528
<212> DNA
<213> Rattus norvegicus
<308> AI639525
<400> 7502

ttccttttt  tttttttca  agctgggga  cgaacccag  gccttgcgc  tcctaggca  60
gcgctctac  actgagcta  atccccaac  cctcacacc  gcttttaaa  aagtgaacc  120
gctttgcta  gggcttacc  gtcaagaca  tgctccctg  tcctcactg  tgatacccg  180
tgttcctga  gatggaggg  ctccaaacc  gtgggagtt  tgtctgata  ggtaacagg  240
atagtctct  ctggtggga  acttccaga  agggggagt  caaagcaag  cagaagttt  300
tgctatttt  tgtttgttg  ttttctttt  gaggcaggg  ctcatttag  caaggctga  360
ctccaactc  ctaagtata  gtagtcaag  atgaccatg  acttctgat  ctcttgcct  420
tactgcttg  gggttggga  tacaggcat  tgtcactgc  tgtaccgtg  atctggtac  480
gagattgga  tctgggctt  atgcatact  gagaagcac  cttaacaa  528



<210> 7503
<211> 413
<212> PRT
<213> Rattus norvegicus
<308> AAK68636
<400> 7503

Met Tyr Asp Pro Glu Arg Arg Trp Ser Leu Ser Phe Ala Gly Cys Gly 
  1               5                  10                  15
Phe Leu Gly Phe Tyr His Val Gly Ala Thr Leu Cys Leu Ser Glu Arg 
             20                  25                  30
Ala Pro His Leu Leu Arg Asp Ala Arg Thr Phe Phe Gly Cys Ser Ala 
         35                  40                  45
Gly Ala Leu His Ala Val Thr Phe Val Cys Ser Leu Pro Leu Gly Arg 
     50                  55                  60
Ile Met Glu Ile Leu Met Asp Leu Val Arg Lys Ala Arg Ser Arg Asn 
 65                  70                  75                  80
Ile Gly Thr Leu His Pro Phe Phe Asn Ile Asn Lys Cys Ile Arg Asp 
                 85                  90                  95
Gly Leu Gln Glu Ser Leu Pro Asp Asn Val His Gln Val Ile Ser Gly 
             100                105                110
Lys Val His Ile Ser Leu Thr Arg Val Ser Asp Gly Glu Asn Val Leu 
         115                120                125
Val Ser Glu Phe His Ser Lys Asp Glu Val Val Asp Ala Leu Val Cys 
     130                135                140
Ser Cys Phe Ile Pro Leu Phe Ser Gly Leu Ile Pro Pro Ser Phe Arg 
 145                150                155                160
Gly Glu Arg Tyr Val Asp Gly Gly Val Ser Asp Asn Val Pro Val Leu 
                 165                170                175
Asp Ala Lys Thr Thr Ile Thr Val Ser Pro Phe Tyr Gly Glu His Asp 
             180                185                190
Ile Cys Pro Lys Val Lys Ser Thr Asn Phe Phe His Val Asn Ile Thr 
         195                200                205
Asn Leu Ser Leu Arg Leu Cys Thr Gly Asn Leu Gln Leu Leu Thr Arg 
     210                215                220
Ala Leu Phe Pro Ser Asp Val Lys Val Met Gly Glu Leu Cys Tyr Gln 
 225                230                235                240
Gly Tyr Leu Asp Ala Phe Arg Phe Leu Glu Glu Asn Gly Ile Cys Asn 
                 245                250                255
Gly Pro Gln Arg Ser Leu Ser Leu Ser Leu Val Ala Pro Glu Ala Cys 
             260                265                270
Leu Glu Asn Gly Lys Leu Val Gly Asp Lys Val Pro Val Ser Leu Cys 
         275                280                285
Phe Thr Asp Glu Asn Ile Trp Glu Thr Leu Ser Pro Glu Leu Ser Thr 
     290                295                300
Ala Leu Ser Glu Ala Ile Lys Asp Arg Glu Gly Tyr Leu Ser Lys Val 
 305                310                315                320
Cys Asn Leu Leu Pro Val Arg Ile Leu Ser Tyr Ile Met Leu Pro Cys 
                 325                330                335
Ser Leu Pro Val Glu Ser Ala Ile Ala Ala Val His Arg Leu Val Thr 
             340                345                350
Trp Leu Pro Asp Ile Gln Asp Asp Ile Gln Trp Leu Gln Trp Ala Thr 
         355                360                365
Ser Gln Val Cys Ala Arg Met Thr Met Cys Leu Leu Pro Ser Thr Arg 
     370                375                380
Ser Arg Ala Ser Lys Asp Asp His Arg Met Leu Lys His Gly His His 
 385                390                395                400
Pro Ser Pro His Lys Pro Gln Gly Asn Ser Ala Gly Leu 
                 405                410



<210> 7504
<211> 453
<212> DNA
<213> Rattus norvegicus
<308> AI639534
<400> 7504

ttctaaaaa  gctggttta  tgaggttta  aaggtcagg  ggtcaaaat  gaggcaagg  60
attttaggg  ttcttctct  ctggatctc  gcaggaagg  acatgtaga  atggccgtt  120
ctcttccac  accagcttc  gcccctgta  cacctcaca  agtggccgt  ggatccccc  180
gaaggtaac  ttcttctca  cctgacctt  aaccatgga  actgtaggc  agtacttgg  240
gagcaaagg  gtgcaaagt  gctgacgga  acgggtggg  ttgggtcca  atggtggtg  300
gcacagacc  caggtactc  actgtgacc  tgaaccttt  aagacacag  tatggatgt  360
atagcagtg  cgaatatct  ggagtttcc  agtacatgg  tgcccatca  atttgcggc  420
accacagct  cttgaacgt  actgctggc  tgg  453



<210> 7505
<211> 437
<212> PRT
<213> Rattus norvegicus
<308> CAA31389
<400> 7505

Cys Phe Thr Gln Tyr Glu Glu Ser Ser Gly Arg Cys Lys Gly Leu Leu 
  1               5                  10                  15
Gly Arg Asp Ile Arg Val Glu Asp Cys Cys Leu Asn Ala Ala Tyr Ala 
             20                  25                  30
Phe Gln Glu His Asp Gly Gly Leu Cys Gln Ala Cys Arg Ser Pro Gln 
         35                  40                  45
Trp Ser Ala Trp Ser Leu Trp Gly Pro Cys Ser Val Thr Cys Ser Glu 
     50                  55                  60
Gly Ser Gln Leu Arg His Arg Arg Cys Val Gly Arg Gly Gly Gln Cys 
 65                  70                  75                  80
Ser Glu Asn Val Ala Pro Gly Thr Leu Glu Trp Gln Leu Gln Ala Cys 
                 85                  90                  95
Glu Asp Gln Pro Cys Cys Pro Glu Met Gly Gly Trp Ser Glu Trp Gly 
             100                105                110
Pro Trp Gly Pro Cys Ser Val Thr Cys Ser Lys Gly Thr Gln Ile Arg 
         115                120                125
Gln Arg Val Cys Asp Asn Pro Ala Pro Lys Cys Gly Gly His Cys Pro 
     130                135                140
Gly Glu Ala Gln Gln Ser Gln Ala Cys Asp Thr Gln Lys Thr Cys Pro 
 145                150                155                160
Thr His Gly Ala Trp Ala Ser Trp Gly Pro Trp Ser Pro Arg Ser Gly 
                 165                170                175
Ser Cys Leu Gly Gly Ala Gln Glu Pro Lys Glu Thr Arg Ser Arg Ser 
             180                185                190
Cys Ser Ala Pro Ala Pro Ser His Gln Pro Pro Gly Lys Pro Cys Ser 
         195                200                205
Gly Pro Ala Tyr Glu His Lys Ala Cys Ser Gly Leu Pro Pro Cys Pro 
     210                215                220
Val Ala Gly Gly Trp Gly Pro Trp Ser Pro Leu Ser Pro Cys Ser Val 
 225                230                235                240
Thr Cys Gly Leu Gly Gln Thr Leu Glu Gln Arg Thr Cys Asp His Pro 
                 245                250                255
Ala Pro Arg His Gly Gly Pro Phe Cys Ala Gly Asp Ala Thr Arg Asn 
             260                265                270
Gln Met Cys Asn Lys Ala Val Pro Cys Pro Val Asn Gly Glu Trp Glu 
         275                280                285
Ala Trp Gly Lys Trp Ser Asp Cys Ser Arg Leu Arg Met Ser Ile Asn 
     290                295                300
Cys Glu Gly Thr Pro Gly Gln Gln Ser Arg Ser Arg Ser Cys Gly Asp 
 305                310                315                320
Arg Lys Phe Asn Gly Lys Pro Cys Ala Gly Lys Leu Gln Asp Ile Arg 
                 325                330                335
His Cys Tyr Asn Ile His Asn Cys Ile Met Lys Gly Ser Trp Ser Gln 
             340                345                350
Trp Ser Thr Trp Ser Leu Cys Thr Pro Pro Cys Ser Pro Asn Ala Thr 
         355                360                365
Arg Val Arg Gln Arg Leu Cys Thr Pro Leu Leu Pro Lys Tyr Pro Pro 
     370                375                380
Thr Val Ser Met Val Glu Gly Gln Gly Glu Lys Asn Val Thr Phe Trp 
 385                390                395                400
Gly Thr Pro Arg Pro Leu Cys Glu Ala Leu Gln Gly Gln Lys Leu Val 
                 405                410                415
Val Glu Glu Lys Arg Ser Cys Leu His Val Pro Val Cys Lys Asp Pro 
             420                425                430
Glu Glu Lys Lys Pro 
         435



<210> 7506
<211> 1553
<212> DNA
<213> Homo sapiens
<308> X57748
<400> 7506

gagcctatc  acccagata  agcgggacc  cctctctgg  agaggtgca  ggggcagta  60
tcaacatga  cacagaggg  gcgcaggcc  ctcgattgt  gctgccgcc  ctgctcctg  120
tgctcaccc  gccagccac  ggctcagac  ccgtgctct  cttcaccca  tatgaagaa  180
cctccggca  gtgcaaggg  ctcctgggg  gtggtgtca  cgtggaaga  tgctgtctc  240
acactgcct  tgcctacca  aaacgtagt  gtgggctct  tcagccttg  aggtcccca  300
gatggtccc  gtggtccac  tgggccccc  gttcggtga  gtgctctga  ggctcccag  360
tgcggtacc  gcgctgtgt  ggctggaat  ggcagtgct  tggaaaggt  gcacctggg  420
ccctggagt  gcagctcca  gcctgtgag  accagcagt  ctgtcctga  atgggcggc  480
ggtctggct  ggggccctg  gagccttgc  ctgtcacct  ctccaaagg  acccggacc  540
gcaggcgag  ctgtaatca  cctgctccc  agtgtgggg  ccactgccc  ggacaggca  600
aggaatcag  ggcctgtga  acccagcag  tctgcccca  acacggggc  tgggccacc  660
ggggcccct  gaccccctg  tcagcctcc  gccacggtg  accccacga  cctaaggag  720
cacgaagcc  caagtgttc  gcacctgag  cctcccaga  acctcctgg  aagccctgc  780
cggggctag  ctacgagca  cggaggtgc  ccggcctgc  accctgccc  gtggctggg  840
gctgggggc  ttggggccc  gtgagcccc  gccctgtga  ctgtggcct  ggccagacc  900
tggaacaac  gacgtgcaa  caccctgtg  cccagcatg  gggcccctt  tgtgctggc  960
atgccaccc  gacccacat  tgcaacaca  ctgtgccct  ccctgtgga  ggggagtgg  1020
actcgtggg  ggagtggag  ccctgtatc  gacggaaca  gaagtccat  agctgtcaa  1080
aaatcccgg  ccagcagtc  cgcgggagg  cctgcaggg  ccgcaagtt  gacggacat  1140
gatgtgccg  gcaacagca  gatatccgg  actgctaca  catccagca  tgccccttg  1200
aaggatcat  gtcagagtg  agtacctgg  ggctgtgca  gcccccctg  ggacctaat  1260
ctacccgtg  ccgccagcg  ctctgcaca  ccttgctcc  caagtaccc  cccaccgtt  1320
ccatggtcg  aggtcaggg  gagaagaac  tgaccttct  ggggagacc  ctgccacgg  1380
gtgaggagc  acaagggca  aagctggtg  tggaggaga  acgaccatg  ctacacgtg  1440
ctgcttgca  agaccctga  gaagaggaa  tctaacact  ctctcctcc  ctctgagcc  1500
tgaccttcc  aacctcaat  aactagcct  ttcgaaaaa  aaaaaaaaa  aaa  1553



<210> 7507
<211> 469
<212> PRT
<213> Homo sapiens
<308> P27918
<400> 7507

Met Ile Thr Glu Gly Ala Gln Ala Pro Arg Leu Leu Leu Pro Pro Leu 
  1               5                  10                  15
Leu Leu Leu Leu Thr Leu Pro Ala Thr Gly Ser Asp Pro Val Leu Cys 
             20                  25                  30
Phe Thr Gln Tyr Glu Glu Ser Ser Gly Lys Cys Lys Gly Leu Leu Gly 
         35                  40                  45
Gly Gly Val Ser Val Glu Asp Cys Cys Leu Asn Thr Ala Phe Ala Tyr 
     50                  55                  60
Gln Lys Arg Ser Gly Gly Leu Cys Gln Pro Cys Arg Ser Pro Arg Trp 
 65                  70                  75                  80
Ser Leu Trp Ser Thr Trp Ala Pro Cys Ser Val Thr Cys Ser Glu Gly 
                 85                  90                  95
Ser Gln Leu Arg Tyr Arg Arg Cys Val Gly Trp Asn Gly Gln Cys Ser 
             100                105                110
Gly Lys Val Ala Pro Gly Thr Leu Glu Trp Gln Leu Gln Ala Cys Glu 
         115                120                125
Asp Gln Gln Cys Cys Pro Glu Met Gly Gly Trp Ser Gly Trp Gly Pro 
     130                135                140
Trp Glu Pro Cys Ser Val Thr Cys Ser Lys Gly Thr Arg Thr Arg Arg 
 145                150                155                160
Arg Ala Cys Asn His Pro Ala Pro Lys Cys Gly Gly His Cys Pro Gly 
                 165                170                175
Gln Ala Gln Glu Ser Glu Ala Cys Asp Thr Gln Gln Val Cys Pro Thr 
             180                185                190
His Gly Ala Trp Ala Thr Trp Gly Pro Trp Thr Pro Cys Ser Ala Ser 
         195                200                205
Cys His Gly Gly Pro His Glu Pro Lys Glu Thr Arg Ser Arg Lys Cys 
     210                215                220
Ser Ala Pro Glu Pro Ser Gln Lys Pro Pro Gly Lys Pro Cys Pro Gly 
 225                230                235                240
Leu Ala Tyr Glu Gln Arg Arg Cys Thr Gly Leu Pro Pro Cys Pro Val 
                 245                250                255
Ala Gly Gly Trp Gly Pro Trp Gly Pro Val Ser Pro Cys Pro Val Thr 
             260                265                270
Cys Gly Leu Gly Gln Thr Met Glu Gln Arg Thr Cys Asn His Pro Val 
         275                280                285
Pro Gln His Gly Gly Pro Phe Cys Ala Gly Asp Ala Thr Arg Thr His 
     290                295                300
Ile Cys Asn Thr Ala Val Pro Cys Pro Val Asp Gly Glu Trp Asp Ser 
 305                310                315                320
Trp Gly Glu Trp Ser Pro Cys Ile Arg Arg Asn Met Lys Ser Ile Ser 
                 325                330                335
Cys Gln Glu Ile Pro Gly Gln Gln Ser Arg Gly Arg Thr Cys Arg Gly 
             340                345                350
Arg Lys Phe Asp Gly His Arg Cys Ala Gly Gln Gln Gln Asp Ile Arg 
         355                360                365
His Cys Tyr Ser Ile Gln His Cys Pro Leu Lys Gly Ser Trp Ser Glu 
     370                375                380
Trp Ser Thr Trp Gly Leu Cys Met Pro Pro Cys Gly Pro Asn Pro Thr 
 385                390                395                400
Arg Ala Arg Gln Arg Leu Cys Thr Pro Leu Leu Pro Lys Tyr Pro Pro 
                 405                410                415
Thr Val Ser Met Val Glu Gly Gln Gly Glu Lys Asn Val Thr Phe Trp 
             420                425                430
Gly Arg Pro Leu Pro Arg Cys Glu Glu Leu Gln Gly Gln Lys Leu Val 
         435                440                445
Val Glu Glu Lys Arg Pro Cys Leu His Val Pro Ala Cys Lys Asp Pro 
     450                455                460
Glu Glu Glu Glu Leu 
 465



<210> 7508
<211> 453
<212> DNA
<213> Rattus norvegicus
<308> AI639534
<400> 7508

ttctaaaaa  gctggttta  tgaggttta  aaggtcagg  ggtcaaaat  gaggcaagg  60
attttaggg  ttcttctct  ctggatctc  gcaggaagg  acatgtaga  atggccgtt  120
ctcttccac  accagcttc  gcccctgta  cacctcaca  agtggccgt  ggatccccc  180
gaaggtaac  ttcttctca  cctgacctt  aaccatgga  actgtaggc  agtacttgg  240
gagcaaagg  gtgcaaagt  gctgacgga  acgggtggg  ttgggtcca  atggtggtg  300
gcacagacc  caggtactc  actgtgacc  tgaaccttt  aagacacag  tatggatgt  360
atagcagtg  cgaatatct  ggagtttcc  agtacatgg  tgcccatca  atttgcggc  420
accacagct  cttgaacgt  actgctggc  tgg  453



<210> 7509
<211> 437
<212> PRT
<213> Rattus norvegicus
<308> CAA31389
<400> 7509

Cys Phe Thr Gln Tyr Glu Glu Ser Ser Gly Arg Cys Lys Gly Leu Leu 
  1               5                  10                  15
Gly Arg Asp Ile Arg Val Glu Asp Cys Cys Leu Asn Ala Ala Tyr Ala 
             20                  25                  30
Phe Gln Glu His Asp Gly Gly Leu Cys Gln Ala Cys Arg Ser Pro Gln 
         35                  40                  45
Trp Ser Ala Trp Ser Leu Trp Gly Pro Cys Ser Val Thr Cys Ser Glu 
     50                  55                  60
Gly Ser Gln Leu Arg His Arg Arg Cys Val Gly Arg Gly Gly Gln Cys 
 65                  70                  75                  80
Ser Glu Asn Val Ala Pro Gly Thr Leu Glu Trp Gln Leu Gln Ala Cys 
                 85                  90                  95
Glu Asp Gln Pro Cys Cys Pro Glu Met Gly Gly Trp Ser Glu Trp Gly 
             100                105                110
Pro Trp Gly Pro Cys Ser Val Thr Cys Ser Lys Gly Thr Gln Ile Arg 
         115                120                125
Gln Arg Val Cys Asp Asn Pro Ala Pro Lys Cys Gly Gly His Cys Pro 
     130                135                140
Gly Glu Ala Gln Gln Ser Gln Ala Cys Asp Thr Gln Lys Thr Cys Pro 
 145                150                155                160
Thr His Gly Ala Trp Ala Ser Trp Gly Pro Trp Ser Pro Arg Ser Gly 
                 165                170                175
Ser Cys Leu Gly Gly Ala Gln Glu Pro Lys Glu Thr Arg Ser Arg Ser 
             180                185                190
Cys Ser Ala Pro Ala Pro Ser His Gln Pro Pro Gly Lys Pro Cys Ser 
         195                200                205
Gly Pro Ala Tyr Glu His Lys Ala Cys Ser Gly Leu Pro Pro Cys Pro 
     210                215                220
Val Ala Gly Gly Trp Gly Pro Trp Ser Pro Leu Ser Pro Cys Ser Val 
 225                230                235                240
Thr Cys Gly Leu Gly Gln Thr Leu Glu Gln Arg Thr Cys Asp His Pro 
                 245                250                255
Ala Pro Arg His Gly Gly Pro Phe Cys Ala Gly Asp Ala Thr Arg Asn 
             260                265                270
Gln Met Cys Asn Lys Ala Val Pro Cys Pro Val Asn Gly Glu Trp Glu 
         275                280                285
Ala Trp Gly Lys Trp Ser Asp Cys Ser Arg Leu Arg Met Ser Ile Asn 
     290                295                300
Cys Glu Gly Thr Pro Gly Gln Gln Ser Arg Ser Arg Ser Cys Gly Asp 
 305                310                315                320
Arg Lys Phe Asn Gly Lys Pro Cys Ala Gly Lys Leu Gln Asp Ile Arg 
                 325                330                335
His Cys Tyr Asn Ile His Asn Cys Ile Met Lys Gly Ser Trp Ser Gln 
             340                345                350
Trp Ser Thr Trp Ser Leu Cys Thr Pro Pro Cys Ser Pro Asn Ala Thr 
         355                360                365
Arg Val Arg Gln Arg Leu Cys Thr Pro Leu Leu Pro Lys Tyr Pro Pro 
     370                375                380
Thr Val Ser Met Val Glu Gly Gln Gly Glu Lys Asn Val Thr Phe Trp 
 385                390                395                400
Gly Thr Pro Arg Pro Leu Cys Glu Ala Leu Gln Gly Gln Lys Leu Val 
                 405                410                415
Val Glu Glu Lys Arg Ser Cys Leu His Val Pro Val Cys Lys Asp Pro 
             420                425                430
Glu Glu Lys Lys Pro 
         435



<210> 7510
<211> 1553
<212> DNA
<213> Homo sapiens
<308> X57748
<400> 7510

gagcctatc  acccagata  agcgggacc  cctctctgg  agaggtgca  ggggcagta  60
tcaacatga  cacagaggg  gcgcaggcc  ctcgattgt  gctgccgcc  ctgctcctg  120
tgctcaccc  gccagccac  ggctcagac  ccgtgctct  cttcaccca  tatgaagaa  180
cctccggca  gtgcaaggg  ctcctgggg  gtggtgtca  cgtggaaga  tgctgtctc  240
acactgcct  tgcctacca  aaacgtagt  gtgggctct  tcagccttg  aggtcccca  300
gatggtccc  gtggtccac  tgggccccc  gttcggtga  gtgctctga  ggctcccag  360
tgcggtacc  gcgctgtgt  ggctggaat  ggcagtgct  tggaaaggt  gcacctggg  420
ccctggagt  gcagctcca  gcctgtgag  accagcagt  ctgtcctga  atgggcggc  480
ggtctggct  ggggccctg  gagccttgc  ctgtcacct  ctccaaagg  acccggacc  540
gcaggcgag  ctgtaatca  cctgctccc  agtgtgggg  ccactgccc  ggacaggca  600
aggaatcag  ggcctgtga  acccagcag  tctgcccca  acacggggc  tgggccacc  660
ggggcccct  gaccccctg  tcagcctcc  gccacggtg  accccacga  cctaaggag  720
cacgaagcc  caagtgttc  gcacctgag  cctcccaga  acctcctgg  aagccctgc  780
cggggctag  ctacgagca  cggaggtgc  ccggcctgc  accctgccc  gtggctggg  840
gctgggggc  ttggggccc  gtgagcccc  gccctgtga  ctgtggcct  ggccagacc  900
tggaacaac  gacgtgcaa  caccctgtg  cccagcatg  gggcccctt  tgtgctggc  960
atgccaccc  gacccacat  tgcaacaca  ctgtgccct  ccctgtgga  ggggagtgg  1020
actcgtggg  ggagtggag  ccctgtatc  gacggaaca  gaagtccat  agctgtcaa  1080
aaatcccgg  ccagcagtc  cgcgggagg  cctgcaggg  ccgcaagtt  gacggacat  1140
gatgtgccg  gcaacagca  gatatccgg  actgctaca  catccagca  tgccccttg  1200
aaggatcat  gtcagagtg  agtacctgg  ggctgtgca  gcccccctg  ggacctaat  1260
ctacccgtg  ccgccagcg  ctctgcaca  ccttgctcc  caagtaccc  cccaccgtt  1320
ccatggtcg  aggtcaggg  gagaagaac  tgaccttct  ggggagacc  ctgccacgg  1380
gtgaggagc  acaagggca  aagctggtg  tggaggaga  acgaccatg  ctacacgtg  1440
ctgcttgca  agaccctga  gaagaggaa  tctaacact  ctctcctcc  ctctgagcc  1500
tgaccttcc  aacctcaat  aactagcct  ttcgaaaaa  aaaaaaaaa  aaa  1553



<210> 7511
<211> 469
<212> PRT
<213> Homo sapiens
<308> P27918
<400> 7511

Met Ile Thr Glu Gly Ala Gln Ala Pro Arg Leu Leu Leu Pro Pro Leu 
  1               5                  10                  15
Leu Leu Leu Leu Thr Leu Pro Ala Thr Gly Ser Asp Pro Val Leu Cys 
             20                  25                  30
Phe Thr Gln Tyr Glu Glu Ser Ser Gly Lys Cys Lys Gly Leu Leu Gly 
         35                  40                  45
Gly Gly Val Ser Val Glu Asp Cys Cys Leu Asn Thr Ala Phe Ala Tyr 
     50                  55                  60
Gln Lys Arg Ser Gly Gly Leu Cys Gln Pro Cys Arg Ser Pro Arg Trp 
 65                  70                  75                  80
Ser Leu Trp Ser Thr Trp Ala Pro Cys Ser Val Thr Cys Ser Glu Gly 
                 85                  90                  95
Ser Gln Leu Arg Tyr Arg Arg Cys Val Gly Trp Asn Gly Gln Cys Ser 
             100                105                110
Gly Lys Val Ala Pro Gly Thr Leu Glu Trp Gln Leu Gln Ala Cys Glu 
         115                120                125
Asp Gln Gln Cys Cys Pro Glu Met Gly Gly Trp Ser Gly Trp Gly Pro 
     130                135                140
Trp Glu Pro Cys Ser Val Thr Cys Ser Lys Gly Thr Arg Thr Arg Arg 
 145                150                155                160
Arg Ala Cys Asn His Pro Ala Pro Lys Cys Gly Gly His Cys Pro Gly 
                 165                170                175
Gln Ala Gln Glu Ser Glu Ala Cys Asp Thr Gln Gln Val Cys Pro Thr 
             180                185                190
His Gly Ala Trp Ala Thr Trp Gly Pro Trp Thr Pro Cys Ser Ala Ser 
         195                200                205
Cys His Gly Gly Pro His Glu Pro Lys Glu Thr Arg Ser Arg Lys Cys 
     210                215                220
Ser Ala Pro Glu Pro Ser Gln Lys Pro Pro Gly Lys Pro Cys Pro Gly 
 225                230                235                240
Leu Ala Tyr Glu Gln Arg Arg Cys Thr Gly Leu Pro Pro Cys Pro Val 
                 245                250                255
Ala Gly Gly Trp Gly Pro Trp Gly Pro Val Ser Pro Cys Pro Val Thr 
             260                265                270
Cys Gly Leu Gly Gln Thr Met Glu Gln Arg Thr Cys Asn His Pro Val 
         275                280                285
Pro Gln His Gly Gly Pro Phe Cys Ala Gly Asp Ala Thr Arg Thr His 
     290                295                300
Ile Cys Asn Thr Ala Val Pro Cys Pro Val Asp Gly Glu Trp Asp Ser 
 305                310                315                320
Trp Gly Glu Trp Ser Pro Cys Ile Arg Arg Asn Met Lys Ser Ile Ser 
                 325                330                335
Cys Gln Glu Ile Pro Gly Gln Gln Ser Arg Gly Arg Thr Cys Arg Gly 
             340                345                350
Arg Lys Phe Asp Gly His Arg Cys Ala Gly Gln Gln Gln Asp Ile Arg 
         355                360                365
His Cys Tyr Ser Ile Gln His Cys Pro Leu Lys Gly Ser Trp Ser Glu 
     370                375                380
Trp Ser Thr Trp Gly Leu Cys Met Pro Pro Cys Gly Pro Asn Pro Thr 
 385                390                395                400
Arg Ala Arg Gln Arg Leu Cys Thr Pro Leu Leu Pro Lys Tyr Pro Pro 
                 405                410                415
Thr Val Ser Met Val Glu Gly Gln Gly Glu Lys Asn Val Thr Phe Trp 
             420                425                430
Gly Arg Pro Leu Pro Arg Cys Glu Glu Leu Gln Gly Gln Lys Leu Val 
         435                440                445
Val Glu Glu Lys Arg Pro Cys Leu His Val Pro Ala Cys Lys Asp Pro 
     450                455                460
Glu Glu Glu Glu Leu 
 465



<210> 7512
<211> 453
<212> DNA
<213> Rattus norvegicus
<308> AI639534
<400> 7512

ttctaaaaa  gctggttta  tgaggttta  aaggtcagg  ggtcaaaat  gaggcaagg  60
attttaggg  ttcttctct  ctggatctc  gcaggaagg  acatgtaga  atggccgtt  120
ctcttccac  accagcttc  gcccctgta  cacctcaca  agtggccgt  ggatccccc  180
gaaggtaac  ttcttctca  cctgacctt  aaccatgga  actgtaggc  agtacttgg  240
gagcaaagg  gtgcaaagt  gctgacgga  acgggtggg  ttgggtcca  atggtggtg  300
gcacagacc  caggtactc  actgtgacc  tgaaccttt  aagacacag  tatggatgt  360
atagcagtg  cgaatatct  ggagtttcc  agtacatgg  tgcccatca  atttgcggc  420
accacagct  cttgaacgt  actgctggc  tgg  453



<210> 7513
<211> 437
<212> PRT
<213> Rattus norvegicus
<308> CAA31389
<400> 7513

Cys Phe Thr Gln Tyr Glu Glu Ser Ser Gly Arg Cys Lys Gly Leu Leu 
  1               5                  10                  15
Gly Arg Asp Ile Arg Val Glu Asp Cys Cys Leu Asn Ala Ala Tyr Ala 
             20                  25                  30
Phe Gln Glu His Asp Gly Gly Leu Cys Gln Ala Cys Arg Ser Pro Gln 
         35                  40                  45
Trp Ser Ala Trp Ser Leu Trp Gly Pro Cys Ser Val Thr Cys Ser Glu 
     50                  55                  60
Gly Ser Gln Leu Arg His Arg Arg Cys Val Gly Arg Gly Gly Gln Cys 
 65                  70                  75                  80
Ser Glu Asn Val Ala Pro Gly Thr Leu Glu Trp Gln Leu Gln Ala Cys 
                 85                  90                  95
Glu Asp Gln Pro Cys Cys Pro Glu Met Gly Gly Trp Ser Glu Trp Gly 
             100                105                110
Pro Trp Gly Pro Cys Ser Val Thr Cys Ser Lys Gly Thr Gln Ile Arg 
         115                120                125
Gln Arg Val Cys Asp Asn Pro Ala Pro Lys Cys Gly Gly His Cys Pro 
     130                135                140
Gly Glu Ala Gln Gln Ser Gln Ala Cys Asp Thr Gln Lys Thr Cys Pro 
 145                150                155                160
Thr His Gly Ala Trp Ala Ser Trp Gly Pro Trp Ser Pro Arg Ser Gly 
                 165                170                175
Ser Cys Leu Gly Gly Ala Gln Glu Pro Lys Glu Thr Arg Ser Arg Ser 
             180                185                190
Cys Ser Ala Pro Ala Pro Ser His Gln Pro Pro Gly Lys Pro Cys Ser 
         195                200                205
Gly Pro Ala Tyr Glu His Lys Ala Cys Ser Gly Leu Pro Pro Cys Pro 
     210                215                220
Val Ala Gly Gly Trp Gly Pro Trp Ser Pro Leu Ser Pro Cys Ser Val 
 225                230                235                240
Thr Cys Gly Leu Gly Gln Thr Leu Glu Gln Arg Thr Cys Asp His Pro 
                 245                250                255
Ala Pro Arg His Gly Gly Pro Phe Cys Ala Gly Asp Ala Thr Arg Asn 
             260                265                270
Gln Met Cys Asn Lys Ala Val Pro Cys Pro Val Asn Gly Glu Trp Glu 
         275                280                285
Ala Trp Gly Lys Trp Ser Asp Cys Ser Arg Leu Arg Met Ser Ile Asn 
     290                295                300
Cys Glu Gly Thr Pro Gly Gln Gln Ser Arg Ser Arg Ser Cys Gly Asp 
 305                310                315                320
Arg Lys Phe Asn Gly Lys Pro Cys Ala Gly Lys Leu Gln Asp Ile Arg 
                 325                330                335
His Cys Tyr Asn Ile His Asn Cys Ile Met Lys Gly Ser Trp Ser Gln 
             340                345                350
Trp Ser Thr Trp Ser Leu Cys Thr Pro Pro Cys Ser Pro Asn Ala Thr 
         355                360                365
Arg Val Arg Gln Arg Leu Cys Thr Pro Leu Leu Pro Lys Tyr Pro Pro 
     370                375                380
Thr Val Ser Met Val Glu Gly Gln Gly Glu Lys Asn Val Thr Phe Trp 
 385                390                395                400
Gly Thr Pro Arg Pro Leu Cys Glu Ala Leu Gln Gly Gln Lys Leu Val 
                 405                410                415
Val Glu Glu Lys Arg Ser Cys Leu His Val Pro Val Cys Lys Asp Pro 
             420                425                430
Glu Glu Lys Lys Pro 
         435



<210> 7514
<211> 1553
<212> DNA
<213> Homo sapiens
<308> X57748
<400> 7514

gagcctatc  acccagata  agcgggacc  cctctctgg  agaggtgca  ggggcagta  60
tcaacatga  cacagaggg  gcgcaggcc  ctcgattgt  gctgccgcc  ctgctcctg  120
tgctcaccc  gccagccac  ggctcagac  ccgtgctct  cttcaccca  tatgaagaa  180
cctccggca  gtgcaaggg  ctcctgggg  gtggtgtca  cgtggaaga  tgctgtctc  240
acactgcct  tgcctacca  aaacgtagt  gtgggctct  tcagccttg  aggtcccca  300
gatggtccc  gtggtccac  tgggccccc  gttcggtga  gtgctctga  ggctcccag  360
tgcggtacc  gcgctgtgt  ggctggaat  ggcagtgct  tggaaaggt  gcacctggg  420
ccctggagt  gcagctcca  gcctgtgag  accagcagt  ctgtcctga  atgggcggc  480
ggtctggct  ggggccctg  gagccttgc  ctgtcacct  ctccaaagg  acccggacc  540
gcaggcgag  ctgtaatca  cctgctccc  agtgtgggg  ccactgccc  ggacaggca  600
aggaatcag  ggcctgtga  acccagcag  tctgcccca  acacggggc  tgggccacc  660
ggggcccct  gaccccctg  tcagcctcc  gccacggtg  accccacga  cctaaggag  720
cacgaagcc  caagtgttc  gcacctgag  cctcccaga  acctcctgg  aagccctgc  780
cggggctag  ctacgagca  cggaggtgc  ccggcctgc  accctgccc  gtggctggg  840
gctgggggc  ttggggccc  gtgagcccc  gccctgtga  ctgtggcct  ggccagacc  900
tggaacaac  gacgtgcaa  caccctgtg  cccagcatg  gggcccctt  tgtgctggc  960
atgccaccc  gacccacat  tgcaacaca  ctgtgccct  ccctgtgga  ggggagtgg  1020
actcgtggg  ggagtggag  ccctgtatc  gacggaaca  gaagtccat  agctgtcaa  1080
aaatcccgg  ccagcagtc  cgcgggagg  cctgcaggg  ccgcaagtt  gacggacat  1140
gatgtgccg  gcaacagca  gatatccgg  actgctaca  catccagca  tgccccttg  1200
aaggatcat  gtcagagtg  agtacctgg  ggctgtgca  gcccccctg  ggacctaat  1260
ctacccgtg  ccgccagcg  ctctgcaca  ccttgctcc  caagtaccc  cccaccgtt  1320
ccatggtcg  aggtcaggg  gagaagaac  tgaccttct  ggggagacc  ctgccacgg  1380
gtgaggagc  acaagggca  aagctggtg  tggaggaga  acgaccatg  ctacacgtg  1440
ctgcttgca  agaccctga  gaagaggaa  tctaacact  ctctcctcc  ctctgagcc  1500
tgaccttcc  aacctcaat  aactagcct  ttcgaaaaa  aaaaaaaaa  aaa  1553



<210> 7515
<211> 469
<212> PRT
<213> Homo sapiens
<308> P27918
<400> 7515

Met Ile Thr Glu Gly Ala Gln Ala Pro Arg Leu Leu Leu Pro Pro Leu 
  1               5                  10                  15
Leu Leu Leu Leu Thr Leu Pro Ala Thr Gly Ser Asp Pro Val Leu Cys 
             20                  25                  30
Phe Thr Gln Tyr Glu Glu Ser Ser Gly Lys Cys Lys Gly Leu Leu Gly 
         35                  40                  45
Gly Gly Val Ser Val Glu Asp Cys Cys Leu Asn Thr Ala Phe Ala Tyr 
     50                  55                  60
Gln Lys Arg Ser Gly Gly Leu Cys Gln Pro Cys Arg Ser Pro Arg Trp 
 65                  70                  75                  80
Ser Leu Trp Ser Thr Trp Ala Pro Cys Ser Val Thr Cys Ser Glu Gly 
                 85                  90                  95
Ser Gln Leu Arg Tyr Arg Arg Cys Val Gly Trp Asn Gly Gln Cys Ser 
             100                105                110
Gly Lys Val Ala Pro Gly Thr Leu Glu Trp Gln Leu Gln Ala Cys Glu 
         115                120                125
Asp Gln Gln Cys Cys Pro Glu Met Gly Gly Trp Ser Gly Trp Gly Pro 
     130                135                140
Trp Glu Pro Cys Ser Val Thr Cys Ser Lys Gly Thr Arg Thr Arg Arg 
 145                150                155                160
Arg Ala Cys Asn His Pro Ala Pro Lys Cys Gly Gly His Cys Pro Gly 
                 165                170                175
Gln Ala Gln Glu Ser Glu Ala Cys Asp Thr Gln Gln Val Cys Pro Thr 
             180                185                190
His Gly Ala Trp Ala Thr Trp Gly Pro Trp Thr Pro Cys Ser Ala Ser 
         195                200                205
Cys His Gly Gly Pro His Glu Pro Lys Glu Thr Arg Ser Arg Lys Cys 
     210                215                220
Ser Ala Pro Glu Pro Ser Gln Lys Pro Pro Gly Lys Pro Cys Pro Gly 
 225                230                235                240
Leu Ala Tyr Glu Gln Arg Arg Cys Thr Gly Leu Pro Pro Cys Pro Val 
                 245                250                255
Ala Gly Gly Trp Gly Pro Trp Gly Pro Val Ser Pro Cys Pro Val Thr 
             260                265                270
Cys Gly Leu Gly Gln Thr Met Glu Gln Arg Thr Cys Asn His Pro Val 
         275                280                285
Pro Gln His Gly Gly Pro Phe Cys Ala Gly Asp Ala Thr Arg Thr His 
     290                295                300
Ile Cys Asn Thr Ala Val Pro Cys Pro Val Asp Gly Glu Trp Asp Ser 
 305                310                315                320
Trp Gly Glu Trp Ser Pro Cys Ile Arg Arg Asn Met Lys Ser Ile Ser 
                 325                330                335
Cys Gln Glu Ile Pro Gly Gln Gln Ser Arg Gly Arg Thr Cys Arg Gly 
             340                345                350
Arg Lys Phe Asp Gly His Arg Cys Ala Gly Gln Gln Gln Asp Ile Arg 
         355                360                365
His Cys Tyr Ser Ile Gln His Cys Pro Leu Lys Gly Ser Trp Ser Glu 
     370                375                380
Trp Ser Thr Trp Gly Leu Cys Met Pro Pro Cys Gly Pro Asn Pro Thr 
 385                390                395                400
Arg Ala Arg Gln Arg Leu Cys Thr Pro Leu Leu Pro Lys Tyr Pro Pro 
                 405                410                415
Thr Val Ser Met Val Glu Gly Gln Gly Glu Lys Asn Val Thr Phe Trp 
             420                425                430
Gly Arg Pro Leu Pro Arg Cys Glu Glu Leu Gln Gly Gln Lys Leu Val 
         435                440                445
Val Glu Glu Lys Arg Pro Cys Leu His Val Pro Ala Cys Lys Asp Pro 
     450                455                460
Glu Glu Glu Glu Leu 
 465



<210> 7516
<211> 453
<212> DNA
<213> Rattus norvegicus
<308> AI639534
<400> 7516

ttctaaaaa  gctggttta  tgaggttta  aaggtcagg  ggtcaaaat  gaggcaagg  60
attttaggg  ttcttctct  ctggatctc  gcaggaagg  acatgtaga  atggccgtt  120
ctcttccac  accagcttc  gcccctgta  cacctcaca  agtggccgt  ggatccccc  180
gaaggtaac  ttcttctca  cctgacctt  aaccatgga  actgtaggc  agtacttgg  240
gagcaaagg  gtgcaaagt  gctgacgga  acgggtggg  ttgggtcca  atggtggtg  300
gcacagacc  caggtactc  actgtgacc  tgaaccttt  aagacacag  tatggatgt  360
atagcagtg  cgaatatct  ggagtttcc  agtacatgg  tgcccatca  atttgcggc  420
accacagct  cttgaacgt  actgctggc  tgg  453



<210> 7517
<211> 437
<212> PRT
<213> Rattus norvegicus
<308> CAA31389
<400> 7517

Cys Phe Thr Gln Tyr Glu Glu Ser Ser Gly Arg Cys Lys Gly Leu Leu 
  1               5                  10                  15
Gly Arg Asp Ile Arg Val Glu Asp Cys Cys Leu Asn Ala Ala Tyr Ala 
             20                  25                  30
Phe Gln Glu His Asp Gly Gly Leu Cys Gln Ala Cys Arg Ser Pro Gln 
         35                  40                  45
Trp Ser Ala Trp Ser Leu Trp Gly Pro Cys Ser Val Thr Cys Ser Glu 
     50                  55                  60
Gly Ser Gln Leu Arg His Arg Arg Cys Val Gly Arg Gly Gly Gln Cys 
 65                  70                  75                  80
Ser Glu Asn Val Ala Pro Gly Thr Leu Glu Trp Gln Leu Gln Ala Cys 
                 85                  90                  95
Glu Asp Gln Pro Cys Cys Pro Glu Met Gly Gly Trp Ser Glu Trp Gly 
             100                105                110
Pro Trp Gly Pro Cys Ser Val Thr Cys Ser Lys Gly Thr Gln Ile Arg 
         115                120                125
Gln Arg Val Cys Asp Asn Pro Ala Pro Lys Cys Gly Gly His Cys Pro 
     130                135                140
Gly Glu Ala Gln Gln Ser Gln Ala Cys Asp Thr Gln Lys Thr Cys Pro 
 145                150                155                160
Thr His Gly Ala Trp Ala Ser Trp Gly Pro Trp Ser Pro Arg Ser Gly 
                 165                170                175
Ser Cys Leu Gly Gly Ala Gln Glu Pro Lys Glu Thr Arg Ser Arg Ser 
             180                185                190
Cys Ser Ala Pro Ala Pro Ser His Gln Pro Pro Gly Lys Pro Cys Ser 
         195                200                205
Gly Pro Ala Tyr Glu His Lys Ala Cys Ser Gly Leu Pro Pro Cys Pro 
     210                215                220
Val Ala Gly Gly Trp Gly Pro Trp Ser Pro Leu Ser Pro Cys Ser Val 
 225                230                235                240
Thr Cys Gly Leu Gly Gln Thr Leu Glu Gln Arg Thr Cys Asp His Pro 
                 245                250                255
Ala Pro Arg His Gly Gly Pro Phe Cys Ala Gly Asp Ala Thr Arg Asn 
             260                265                270
Gln Met Cys Asn Lys Ala Val Pro Cys Pro Val Asn Gly Glu Trp Glu 
         275                280                285
Ala Trp Gly Lys Trp Ser Asp Cys Ser Arg Leu Arg Met Ser Ile Asn 
     290                295                300
Cys Glu Gly Thr Pro Gly Gln Gln Ser Arg Ser Arg Ser Cys Gly Asp 
 305                310                315                320
Arg Lys Phe Asn Gly Lys Pro Cys Ala Gly Lys Leu Gln Asp Ile Arg 
                 325                330                335
His Cys Tyr Asn Ile His Asn Cys Ile Met Lys Gly Ser Trp Ser Gln 
             340                345                350
Trp Ser Thr Trp Ser Leu Cys Thr Pro Pro Cys Ser Pro Asn Ala Thr 
         355                360                365
Arg Val Arg Gln Arg Leu Cys Thr Pro Leu Leu Pro Lys Tyr Pro Pro 
     370                375                380
Thr Val Ser Met Val Glu Gly Gln Gly Glu Lys Asn Val Thr Phe Trp 
 385                390                395                400
Gly Thr Pro Arg Pro Leu Cys Glu Ala Leu Gln Gly Gln Lys Leu Val 
                 405                410                415
Val Glu Glu Lys Arg Ser Cys Leu His Val Pro Val Cys Lys Asp Pro 
             420                425                430
Glu Glu Lys Lys Pro 
         435



<210> 7518
<211> 1553
<212> DNA
<213> Homo sapiens
<308> X57748
<400> 7518

gagcctatc  acccagata  agcgggacc  cctctctgg  agaggtgca  ggggcagta  60
tcaacatga  cacagaggg  gcgcaggcc  ctcgattgt  gctgccgcc  ctgctcctg  120
tgctcaccc  gccagccac  ggctcagac  ccgtgctct  cttcaccca  tatgaagaa  180
cctccggca  gtgcaaggg  ctcctgggg  gtggtgtca  cgtggaaga  tgctgtctc  240
acactgcct  tgcctacca  aaacgtagt  gtgggctct  tcagccttg  aggtcccca  300
gatggtccc  gtggtccac  tgggccccc  gttcggtga  gtgctctga  ggctcccag  360
tgcggtacc  gcgctgtgt  ggctggaat  ggcagtgct  tggaaaggt  gcacctggg  420
ccctggagt  gcagctcca  gcctgtgag  accagcagt  ctgtcctga  atgggcggc  480
ggtctggct  ggggccctg  gagccttgc  ctgtcacct  ctccaaagg  acccggacc  540
gcaggcgag  ctgtaatca  cctgctccc  agtgtgggg  ccactgccc  ggacaggca  600
aggaatcag  ggcctgtga  acccagcag  tctgcccca  acacggggc  tgggccacc  660
ggggcccct  gaccccctg  tcagcctcc  gccacggtg  accccacga  cctaaggag  720
cacgaagcc  caagtgttc  gcacctgag  cctcccaga  acctcctgg  aagccctgc  780
cggggctag  ctacgagca  cggaggtgc  ccggcctgc  accctgccc  gtggctggg  840
gctgggggc  ttggggccc  gtgagcccc  gccctgtga  ctgtggcct  ggccagacc  900
tggaacaac  gacgtgcaa  caccctgtg  cccagcatg  gggcccctt  tgtgctggc  960
atgccaccc  gacccacat  tgcaacaca  ctgtgccct  ccctgtgga  ggggagtgg  1020
actcgtggg  ggagtggag  ccctgtatc  gacggaaca  gaagtccat  agctgtcaa  1080
aaatcccgg  ccagcagtc  cgcgggagg  cctgcaggg  ccgcaagtt  gacggacat  1140
gatgtgccg  gcaacagca  gatatccgg  actgctaca  catccagca  tgccccttg  1200
aaggatcat  gtcagagtg  agtacctgg  ggctgtgca  gcccccctg  ggacctaat  1260
ctacccgtg  ccgccagcg  ctctgcaca  ccttgctcc  caagtaccc  cccaccgtt  1320
ccatggtcg  aggtcaggg  gagaagaac  tgaccttct  ggggagacc  ctgccacgg  1380
gtgaggagc  acaagggca  aagctggtg  tggaggaga  acgaccatg  ctacacgtg  1440
ctgcttgca  agaccctga  gaagaggaa  tctaacact  ctctcctcc  ctctgagcc  1500
tgaccttcc  aacctcaat  aactagcct  ttcgaaaaa  aaaaaaaaa  aaa  1553



<210> 7519
<211> 469
<212> PRT
<213> Homo sapiens
<308> P27918
<400> 7519

Met Ile Thr Glu Gly Ala Gln Ala Pro Arg Leu Leu Leu Pro Pro Leu 
  1               5                  10                  15
Leu Leu Leu Leu Thr Leu Pro Ala Thr Gly Ser Asp Pro Val Leu Cys 
             20                  25                  30
Phe Thr Gln Tyr Glu Glu Ser Ser Gly Lys Cys Lys Gly Leu Leu Gly 
         35                  40                  45
Gly Gly Val Ser Val Glu Asp Cys Cys Leu Asn Thr Ala Phe Ala Tyr 
     50                  55                  60
Gln Lys Arg Ser Gly Gly Leu Cys Gln Pro Cys Arg Ser Pro Arg Trp 
 65                  70                  75                  80
Ser Leu Trp Ser Thr Trp Ala Pro Cys Ser Val Thr Cys Ser Glu Gly 
                 85                  90                  95
Ser Gln Leu Arg Tyr Arg Arg Cys Val Gly Trp Asn Gly Gln Cys Ser 
             100                105                110
Gly Lys Val Ala Pro Gly Thr Leu Glu Trp Gln Leu Gln Ala Cys Glu 
         115                120                125
Asp Gln Gln Cys Cys Pro Glu Met Gly Gly Trp Ser Gly Trp Gly Pro 
     130                135                140
Trp Glu Pro Cys Ser Val Thr Cys Ser Lys Gly Thr Arg Thr Arg Arg 
 145                150                155                160
Arg Ala Cys Asn His Pro Ala Pro Lys Cys Gly Gly His Cys Pro Gly 
                 165                170                175
Gln Ala Gln Glu Ser Glu Ala Cys Asp Thr Gln Gln Val Cys Pro Thr 
             180                185                190
His Gly Ala Trp Ala Thr Trp Gly Pro Trp Thr Pro Cys Ser Ala Ser 
         195                200                205
Cys His Gly Gly Pro His Glu Pro Lys Glu Thr Arg Ser Arg Lys Cys 
     210                215                220
Ser Ala Pro Glu Pro Ser Gln Lys Pro Pro Gly Lys Pro Cys Pro Gly 
 225                230                235                240
Leu Ala Tyr Glu Gln Arg Arg Cys Thr Gly Leu Pro Pro Cys Pro Val 
                 245                250                255
Ala Gly Gly Trp Gly Pro Trp Gly Pro Val Ser Pro Cys Pro Val Thr 
             260                265                270
Cys Gly Leu Gly Gln Thr Met Glu Gln Arg Thr Cys Asn His Pro Val 
         275                280                285
Pro Gln His Gly Gly Pro Phe Cys Ala Gly Asp Ala Thr Arg Thr His 
     290                295                300
Ile Cys Asn Thr Ala Val Pro Cys Pro Val Asp Gly Glu Trp Asp Ser 
 305                310                315                320
Trp Gly Glu Trp Ser Pro Cys Ile Arg Arg Asn Met Lys Ser Ile Ser 
                 325                330                335
Cys Gln Glu Ile Pro Gly Gln Gln Ser Arg Gly Arg Thr Cys Arg Gly 
             340                345                350
Arg Lys Phe Asp Gly His Arg Cys Ala Gly Gln Gln Gln Asp Ile Arg 
         355                360                365
His Cys Tyr Ser Ile Gln His Cys Pro Leu Lys Gly Ser Trp Ser Glu 
     370                375                380
Trp Ser Thr Trp Gly Leu Cys Met Pro Pro Cys Gly Pro Asn Pro Thr 
 385                390                395                400
Arg Ala Arg Gln Arg Leu Cys Thr Pro Leu Leu Pro Lys Tyr Pro Pro 
                 405                410                415
Thr Val Ser Met Val Glu Gly Gln Gly Glu Lys Asn Val Thr Phe Trp 
             420                425                430
Gly Arg Pro Leu Pro Arg Cys Glu Glu Leu Gln Gly Gln Lys Leu Val 
         435                440                445
Val Glu Glu Lys Arg Pro Cys Leu His Val Pro Ala Cys Lys Asp Pro 
     450                455                460
Glu Glu Glu Glu Leu 
 465



<210> 7520
<211> 373
<212> DNA
<213> Rattus norvegicus
<308> H31217
<400> 7520

actcggcag  ttcttaaat  ttattagtt  attagttaa  taatctgaa  gctttggag  60
agaaaatcc  atctcactt  tactctggg  acttttatt  gaggaggtg  ctgatacaa  120
gaagctagt  gcattgaaa  tgttattgg  cagctggct  ggatctttc  gctctgtgg  180
ataagaact  taggtatgt  ggaagtcat  ctagtgttg  tatatctgg  tgagcgtct  240
tcttagttt  ggtttcagt  ctgtgaagg  accatatga  caaggcaac  cttataaag  300
cacacattt  tnggggctg  tttacagtt  cagaagttc  agnccatta  ccatcatgg  360
tggaggcat  aca  373



<210> 7521
<211> 362
<212> DNA
<213> Rattus norvegicus
<308> H31342
<400> 7521

gatttgtga  tctgcagtg  catgtttaa  gtccacgag  gagagatga  tgtaaggaa  60
gaggctgac  tctgaggtg  cgcctctgt  ctgcctgct  tagctgtca  tgacacaga  120
catgagtga  ctggctacc  caggtctct  cccctgtna  aatgttcta  cctcttcta  180
aaacaagat  ggaacagta  aatgagaca  aatactccg  ttaagccag  gagctttgc  240
accatcctc  attcaacca  aagcccagc  tctgacccg  ctgcagcct  cagtctctc  300
aacttttca  cgtatttnt  gtgtgtgga  acacaccat  acacacgtg  agcggtcag  360
ag  362



<210> 7522
<211> 341
<212> DNA
<213> Rattus norvegicus
<308> H31418
<400> 7522

agaatgaat  ccttttaat  ttatacaca  gattatgaa  aggtaatct  aagtattca  60
tcactttct  attggtaga  gtgatacgt  atttggtaa  tatagttac  tatgtttnc  120
tactacgaa  tgttctttt  agtcaagca  caagcattt  caaagctag  tagcagatg  180
gtaccaaca  tggcactgt  cccagtaaa  tcaagactc  tagtaaaat  atttcncta  240
tgttaagga  gtagtcatt  tttttaaaa  aatattaga  cgttatgaa  gtttactct  300
gttaagtta  tgattttat  cattgtgtc  attcttcat  g  341



<210> 7523
<211> 375
<212> DNA
<213> Rattus norvegicus
<308> H31479
<400> 7523

ctaaaaaga  cagctgaaa  accctttca  cgacatgct  actggttgt  accctttga  60
atggtcaca  tatggtcag  atgggtgct  agggctcgg  atagatgca  attataaaa  120
tcttgaaaa  gggatgtnc  ttgtggctt  tttcttggt  aagtgccta  gggcaggag  180
ggggttaac  aaacactgc  cgatgatga  tttnctttt  cacaccagt  cgttcccaa  240
aggccctca  attgcagtg  ttctatcag  agttaaaat  aagacaaga  aaagaaata  300
cctttcaaa  aacagagtc  acacttttt  ccccttaaa  aaatcagca  aagtttttc  360
acataatgt  ccaag  375



<210> 7524
<211> 1393
<212> DNA
<213> Homo sapiens
<308> AL080181
<400> 7524

ggcagccat  gtgcatagc  actaaaatc  gtgaccttg  acatatctt  gatggggag  60
ctcgggaaa  ggtagagga  tcacgttac  atttacatg  tttaaagaa  gaagtgtgg  120
gattttcac  gaaacgtct  ggaaatcta  aagtagtcc  gaaggacag  aactaaact  180
ttaccatat  tttggtaag  ctccagact  cagctaaca  tccctatgg  aagatggca  240
caaaaaaga  agatctata  atatatata  atatatatt  tattacatt  tcagtgagt  300
attttggat  ttgcaaggt  catttttac  attgttaca  tatgtggaa  acttatgct  360
atttattta  gggggaaaa  gtgtcaact  tttgttatt  gaaaacatt  ttatttttc  420
tgtctttat  ttaaccttt  atagaacca  tgcaatatg  gggcctttt  ggaacggac  480
ggtatgtaa  agaaaatcc  ttatcgagc  gcattttat  tacccctcc  ctatcccta  540
gcacttaac  aagacaaaa  gccacaatt  acatccctt  ttcaatgaa  tttataatc  600
gcagctcta  tccgagccc  tagcaccca  tccgaccat  gtataatca  atcaaaggg  660
gagaatcat  tagcatgtt  ttgaaaggt  ttttttcag  tgttctttt  agaaaaaaa  720
aaaaacaaa  acaaaaaca  aaaaaaaaa  tcacaccat  gctcacaga  ttggcatct  780
atttttggg  cctcccatc  ttctgtttt  aaaagtgta  agtagtgca  tgttcctga  840
gtaacttta  ggcttacaa  gttgacatg  ctcaggttc  tgtgttgcg  ttggtgttt  900
ccgtctcag  tagattgca  agtgtaggc  ccacacatt  gaaaaaata  taataaaac  960
aagcaaaaa  aggaaatta  ggattttag  tgtatattg  tttatgtat  ttttcttaa  1020
tatacagtg  actgtttga  atgtattgt  gagtattac  ttgtacagg  tgatcactt  1080
ttttagagt  aagaaagaa  aaacttgtt  tttgtgttt  ttaaaggaa  ataaaataa  1140
gaaggatgt  taattgatg  caaataagc  tgttcttta  tcacaccga  gtcttattt  1200
tccctttag  ccagttctg  ttttaaggt  tacatggac  atgttacag  gtaagaaac  1260
ccatatcca  atgttccca  tcgcatttt  tattggttc  tgtatacca  ttttacaaa  1320
aaaaaaaag  aaaaaaaga  gtactataa  atatctgtc  tcttaaaaa  aaaaattaa  1380
gttaaaaaa  aaa  1393



<210> 7525
<211> 442
<212> PRT
<213> Homo sapiens
<308> AAF69029
<400> 7525

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
  1               5                  10                  15
Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
             20                  25                  30
Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
         35                  40                  45
Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
     50                  55                  60
Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
 65                  70                  75                  80
Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                 85                  90                  95
Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
             100                105                110
Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
         115                120                125
Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
     130                135                140
Arg Asn Leu Met Ile Asp Ile Gln Arg Asp Thr Ala Val Glu Gly Glu 
 145                150                155                160
Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                 165                170                175
Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
             180                185                190
Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
         195                200                205
Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
     210                215                220
Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
 225                230                235                240
Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                 245                250                255
Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
             260                265                270
Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
         275                280                285
Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
     290                295                300
Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
 305                310                315                320
Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                 325                330                335
Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
             340                345                350
Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly Glu Glu Gly Ser 
         355                360                365
Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val Val 
     370                375                380
Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala 
 385                390                395                400
Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp 
                 405                410                415
Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn 
             420                425                430
Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
         435                440



<210> 7526
<211> 375
<212> DNA
<213> Rattus norvegicus
<308> H31479
<400> 7526

ctaaaaaga  cagctgaaa  accctttca  cgacatgct  actggttgt  accctttga  60
atggtcaca  tatggtcag  atgggtgct  agggctcgg  atagatgca  attataaaa  120
tcttgaaaa  gggatgtnc  ttgtggctt  tttcttggt  aagtgccta  gggcaggag  180
ggggttaac  aaacactgc  cgatgatga  tttnctttt  cacaccagt  cgttcccaa  240
aggccctca  attgcagtg  ttctatcag  agttaaaat  aagacaaga  aaagaaata  300
cctttcaaa  aacagagtc  acacttttt  ccccttaaa  aaatcagca  aagtttttc  360
acataatgt  ccaag  375



<210> 7527
<211> 1393
<212> DNA
<213> Homo sapiens
<308> AL080181
<400> 7527

ggcagccat  gtgcatagc  actaaaatc  gtgaccttg  acatatctt  gatggggag  60
ctcgggaaa  ggtagagga  tcacgttac  atttacatg  tttaaagaa  gaagtgtgg  120
gattttcac  gaaacgtct  ggaaatcta  aagtagtcc  gaaggacag  aactaaact  180
ttaccatat  tttggtaag  ctccagact  cagctaaca  tccctatgg  aagatggca  240
caaaaaaga  agatctata  atatatata  atatatatt  tattacatt  tcagtgagt  300
attttggat  ttgcaaggt  catttttac  attgttaca  tatgtggaa  acttatgct  360
atttattta  gggggaaaa  gtgtcaact  tttgttatt  gaaaacatt  ttatttttc  420
tgtctttat  ttaaccttt  atagaacca  tgcaatatg  gggcctttt  ggaacggac  480
ggtatgtaa  agaaaatcc  ttatcgagc  gcattttat  tacccctcc  ctatcccta  540
gcacttaac  aagacaaaa  gccacaatt  acatccctt  ttcaatgaa  tttataatc  600
gcagctcta  tccgagccc  tagcaccca  tccgaccat  gtataatca  atcaaaggg  660
gagaatcat  tagcatgtt  ttgaaaggt  ttttttcag  tgttctttt  agaaaaaaa  720
aaaaacaaa  acaaaaaca  aaaaaaaaa  tcacaccat  gctcacaga  ttggcatct  780
atttttggg  cctcccatc  ttctgtttt  aaaagtgta  agtagtgca  tgttcctga  840
gtaacttta  ggcttacaa  gttgacatg  ctcaggttc  tgtgttgcg  ttggtgttt  900
ccgtctcag  tagattgca  agtgtaggc  ccacacatt  gaaaaaata  taataaaac  960
aagcaaaaa  aggaaatta  ggattttag  tgtatattg  tttatgtat  ttttcttaa  1020
tatacagtg  actgtttga  atgtattgt  gagtattac  ttgtacagg  tgatcactt  1080
ttttagagt  aagaaagaa  aaacttgtt  tttgtgttt  ttaaaggaa  ataaaataa  1140
gaaggatgt  taattgatg  caaataagc  tgttcttta  tcacaccga  gtcttattt  1200
tccctttag  ccagttctg  ttttaaggt  tacatggac  atgttacag  gtaagaaac  1260
ccatatcca  atgttccca  tcgcatttt  tattggttc  tgtatacca  ttttacaaa  1320
aaaaaaaag  aaaaaaaga  gtactataa  atatctgtc  tcttaaaaa  aaaaattaa  1380
gttaaaaaa  aaa  1393



<210> 7528
<211> 442
<212> PRT
<213> Homo sapiens
<308> AAF69029
<400> 7528

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
  1               5                  10                  15
Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
             20                  25                  30
Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
         35                  40                  45
Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
     50                  55                  60
Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
 65                  70                  75                  80
Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                 85                  90                  95
Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
             100                105                110
Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
         115                120                125
Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
     130                135                140
Arg Asn Leu Met Ile Asp Ile Gln Arg Asp Thr Ala Val Glu Gly Glu 
 145                150                155                160
Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                 165                170                175
Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
             180                185                190
Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
         195                200                205
Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
     210                215                220
Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
 225                230                235                240
Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                 245                250                255
Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
             260                265                270
Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
         275                280                285
Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
     290                295                300
Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
 305                310                315                320
Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                 325                330                335
Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
             340                345                350
Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly Glu Glu Gly Ser 
         355                360                365
Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val Val 
     370                375                380
Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala 
 385                390                395                400
Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp 
                 405                410                415
Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn 
             420                425                430
Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
         435                440



<210> 7530
<211> 1923
<212> DNA
<213> Homo sapiens
<308> AK023265
<400> 7530

aaaaaatgc  gacgggata  gggtgtgtg  gtgagggga  ggggcctgt  tggcaactg  420
tcttgcccc  gcgtcccca  aagtgcaga  gcagcggct  cagcatcca  ccagcttgg  480
tgtctggcc  acttccagg  ctctgaaga  acagttaca  gcaggatgc  tttcccaac  540
tctgcgcaa  aatcttccc  tggcctccc  gatgcaaat  acttgtgcc  tggcctgca  600
tccctcagt  tgacaggct  ggaccgacc  tggagcacc  aggactcag  ttcctcagc  660
cagagcagc  cacactcgg  actgagcat  ctccataac  cactgggaa  tgtcctagg  720
aaacccccc  tgagcttcc  gcctctgga  ccccttggg  ctgacttgg  ggacaagtt  780
ccagcaccc  cagttagag  atcacgcct  gacacccgg  ccatcctgg  ctctcgatc  840
agcagcccc  ctgactcag  caccagtgg  ttcagctct  gatcagatc  tctctcaga  900
ttgatttca  gccttcgca  ttctccacc  ctgcccttc  tgtctctgt  agggggtgg  960
cccagagac  ctttaaaga  gggggtagg  tctcggatg  accaagagc  agctgctct  1020
gctgcagtc  ctccctccc  aaccagtgc  tcaaagaga  ggccaggag  ttctgtgtg  1080
ccatcctgg  acctcctcg  agctcccaa  gaccccttc  gcatagaga  agaggccag  1140
ctgcaccga  aagctgcag  tgtgaatga  gccacctgt  cctggagtg  ccagcttcc  1200
ccccggaac  ataagaacc  catctactc  tgcaaggtg  ttctaggag  tgttccttg  1260
gatattaca  aagctggat  agttaacac  ttccgtgtt  ttggctctt  gagtgtgga  1320
tggcctggt  aggatggca  gcatccccg  tgtcctccc  aagggtatg  gtatctggt  1380
ttcgaacta  agaagtctg  ccgatcctt  cttcaggct  gctctcatg  cccgctgag  1440
ccagatggc  tgagtgaat  ttatttcaa  atgtccagc  gaaggatgc  ctgcaagga  1500
gtgcaggtg  tcccctggg  attagccga  agtaacttt  tccggagcc  atctcagag  1560
cttgacccc  gcaggacgg  gtttgtcgg  gctctgcat  gaatgctaa  tgctgaggc  1620
caggcagcc  tcttgaacg  cctatttgg  ggagtggtg  atgccggga  tgacacaga  1680
aagcacaag  atcccattg  ttctggtcg  gtgactttc  ataaccaac  gagttacct  1740
aaagcagtc  gcgctgctt  tgtggagat  aaaaccacc  agttcacaa  gaaggttca  1800
attgacccc  acctggaag  ttctctgtg  catatctgc  gttctcagc  tggtccttt  1860
ttctgtcga  atcaggtct  cttcaaata  ttctgccgg  gctgctggc  ctggcggca  1920
agc  1923



<210> 7531
<211> 487
<212> PRT
<213> Homo sapiens
<308> AK023265
<400> 7531

Met Leu Phe Pro Thr Ser Ala Gln Glu Ser Ser Arg Gly Leu Pro Asp 
  1               5                  10                  15
Ala Asn Asp Leu Cys Leu Gly Leu Gln Ser Leu Ser Leu Thr Gly Trp 
             20                  25                  30
Asp Arg Pro Trp Ser Thr Gln Asp Ser Asp Ser Ser Ala Gln Ser Ser 
         35                  40                  45
Thr His Ser Val Leu Ser Met Leu His Asn Pro Leu Gly Asn Val Leu 
     50                  55                  60
Gly Lys Pro Pro Leu Ser Phe Leu Pro Leu Asp Pro Leu Gly Ser Asp 
 65                  70                  75                  80
Leu Val Asp Lys Phe Pro Ala Pro Ser Val Arg Gly Ser Arg Leu Asp 
                 85                  90                  95
Thr Arg Pro Ile Leu Asp Ser Arg Ser Ser Ser Pro Ser Asp Ser Asp 
             100                105                110
Thr Ser Gly Phe Ser Ser Gly Ser Asp His Leu Ser Asp Leu Ile Ser 
         115                120                125
Ser Leu Arg Ile Ser Pro Pro Leu Pro Phe Leu Ser Leu Ser Gly Gly 
     130                135                140
Gly Pro Arg Asp Pro Leu Lys Met Gly Val Gly Ser Arg Met Asp Gln 
 145                150                155                160
Glu Gln Ala Ala Leu Ala Ala Val Thr Pro Ser Pro Thr Ser Ala Ser 
                 165                170                175
Lys Arg Trp Pro Gly Ala Ser Val Trp Pro Ser Trp Asp Leu Leu Glu 
             180                185                190
Ala Pro Lys Asp Pro Phe Ser Ile Glu Arg Glu Ala Arg Leu His Arg 
         195                200                205
Gln Ala Ala Ala Val Asn Glu Ala Thr Cys Thr Trp Ser Gly Gln Leu 
     210                215                220
Pro Pro Arg Asn Tyr Lys Asn Pro Ile Tyr Ser Cys Lys Val Phe Leu 
 225                230                235                240
Gly Gly Val Pro Trp Asp Ile Thr Glu Ala Gly Leu Val Asn Thr Phe 
                 245                250                255
Arg Val Phe Gly Ser Leu Ser Val Glu Trp Pro Gly Lys Asp Gly Lys 
             260                265                270
His Pro Arg Cys Pro Pro Lys Gly Tyr Val Tyr Leu Val Phe Glu Leu 
         275                280                285
Glu Lys Ser Val Arg Ser Leu Leu Gln Ala Cys Ser His Asp Pro Leu 
     290                295                300
Ser Pro Asp Gly Leu Ser Glu Tyr Tyr Phe Lys Met Ser Ser Arg Arg 
 305                310                315                320
Met Arg Cys Lys Glu Val Gln Val Ile Pro Trp Val Leu Ala Asp Ser 
                 325                330                335
Asn Phe Val Arg Ser Pro Ser Gln Arg Leu Asp Pro Ser Arg Thr Val 
             340                345                350
Phe Val Gly Ala Leu His Gly Met Leu Asn Ala Glu Ala Gln Ala Ala 
         355                360                365
Ile Leu Asn Asp Leu Phe Gly Gly Val Val Tyr Ala Gly Ile Asp Thr 
     370                375                380
Asp Lys His Lys Tyr Pro Ile Gly Ser Gly Arg Val Thr Phe Asn Asn 
 385                390                395                400
Gln Arg Ser Tyr Leu Lys Ala Val Ser Ala Ala Phe Val Glu Ile Lys 
                 405                410                415
Thr Thr Lys Phe Thr Lys Lys Val Gln Ile Asp Pro Tyr Leu Glu Asp 
             420                425                430
Ser Leu Cys His Ile Cys Ser Ser Gln Pro Gly Pro Phe Phe Cys Arg 
         435                440                445
Asp Gln Val Cys Phe Lys Tyr Phe Cys Arg Ser Cys Trp His Trp Arg 
     450                455                460
His Ser Met Glu Gly Leu Arg His His Ser Pro Leu Met Arg Asn Gln 
 465                470                475                480
Lys Asn Arg Asp Ser Ser Ter 
                 485



<210> 7532
<211> 343
<212> DNA
<213> Rattus norvegicus
<308> H31588
<400> 7532

gtattatta  ttttgggta  ttatcccta  gatgtctga  tncctcctt  cagctcctt  60
agtaggctg  tggagaatg  agagagtca  cagtcaagg  acagaaaca  tagagactt  120
cgtgtccca  tatctccct  tgtcacacc  gttaagtta  tacttcttg  aatcctatt  180
tgagtagtt  tttcaagtg  catcttcag  gacctgaca  tttttactt  gcatgaaca  240
ttgaaatat  ctgctaata  ttggtgttt  ctgtcttcc  atccccaag  tctccatgg  300
ctcccttaa  tctattttg  agaccaact  gctgtcaga  ttt  343



<210> 7533
<211> 374
<212> DNA
<213> Homo sapiens
<308> AA947174
<400> 7533

tttaatttt  agtaattta  ttcaataga  atatttcag  aaactgtac  taaattcat  60
ttaagttag  ttatgcaga  acactgaag  tcgcacact  acatttgca  attaaaaag  120
aacaaaaag  gagagagga  ccaagctgc  catcactca  ggaggtcat  gtgcaatcg  180
gtgcttcat  atcagagta  ctcaagtta  ttgggataa  gaataaaaa  ggcttgtgt  240
ttcagatat  ttatcatca  tgggtacct  tccttacag  tgtttgatc  ccttcagat  300
atgttgtga  ccagttccc  accccctcc  cacacacat  ttctttagt  ggatgtaaa  360
caatgaatt  gtca  374



<210> 7534
<211> 498
<212> DNA
<213> Rattus norvegicus
<308> H31590
<400> 7534

ccttcagaa  ttaatcgtt  tcatgttta  ttaaaataa  atctaagaa  agcctatga  60
ctgagcnct  ggaatctta  aatacagtt  gcgaactag  atgagctgt  tgtgatgga  120
gagagaggn  ggcagggct  gggcaggtg  actgcttac  agcgcgctg  gcctgctga  180
gccacattt  ggccaccag  gtactctga  ccatggcat  gctggggat  agtctgatg  240
taagtaaca  cagcattac  taaaatcag  taattcatg  ttattataa  caaaggggg  300
caagtgctt  ctcttgaat  aggatattc  ttaaaactt  aaataataa  aagtcttta  360
ataccatgt  ctcaattac  gaaaataaa  tataaaatt  naatcctta  gtaggaaat  420
gagctcatg  catgcgcta  tnggcttca  ctccctgga  atacaagct  tatgaactc  480
ctgcttcaa  tctgcccc  498



<210> 7535
<211> 349
<212> DNA
<213> Rattus norvegicus
<308> H31665
<400> 7535

atgttcaga  ttattttaa  aacaataca  acaccatct  ggcactgtg  atggaatgt  60
agtncaggt  ggacagggg  attttacag  gcatttaat  ttctgtgta  ccaaatttg  120
atgtaaata  tggaaaaac  agcccgccc  ccgttcacc  ctcaccttc  gtactttaa  180
agccatggc  ttatagacg  tggccacgc  gcctgcaca  gctgtgtgc  ttaggccct  240
tagccttgt  ttacacttg  agcacctac  tctgctggg  ttcaactca  tgcacagca  300
ttgcttagc  tatgtgagg  ccctgcact  aaatgccca  caccacaaa  349



<210> 7536
<211> 340
<212> DNA
<213> Rattus norvegicus
<308> H31695
<400> 7536

gtggagcac  aagatattt  attttctgt  tagggaaga  actcacccc  acctctttc  60
ttttaggat  acagagtgc  tttctcagc  aaaatgatc  ggtcaatta  ctggngtgg  120
ggtgggtgt  attcgttta  acagcagaa  atggccgaa  tgtctggcc  cagattaca  180
cattaacat  gtttgaagg  tcacgtgcc  ngcaatttt  tctgcagac  ctcctaaat  240
tgtcaatac  aacactggt  tggccttta  gatttctat  cacagacag  aggactgtg  300
gggaactgc  gggaagaag  cctccacca  tacccacacg  340



<210> 7537
<211> 518
<212> DNA
<213> Rattus norvegicus
<308> H31802
<400> 7537

agattaaat  agtttattc  caccgatag  caaaggagc  ttagagaca  acagtgtgc  60
gtnccagag  gagctaaca  aagcgttta  aaaggtaga  gccaaaggt  cccattaaa  120
ttatctacg  aattcatag  tgggcagga  aattggttt  ctcccctta  ttttttttt  180
ttaaggttt  tttatttaa  gatttaaag  atatgagta  actgcagct  tcttcagac  240
caccagaag  gggcactag  tctcattac  gatggttgt  agccaccat  tggttgctg  300
gaactgaac  caggaccta  ggaagagca  tcagtgttc  taaccactg  gccatctct  360
cagcttgcc  accccaccc  ccacccccg  tgtttcttt  tcctgtgta  aataatgaa  420
agatcactt  ctctagtca  ataacaatg  tggagttta  aaaatcaga  agcagggac  480
ccattatct  tctctgatc  caccagcag  ccactaag  518



<210> 7538
<211> 445
<212> DNA
<213> Rattus norvegicus
<308> H31887
<400> 7538

ctactagag  ttttattta  tgaggtctc  atcccaacc  gtcatttaa  aaccaagta  60
cacagacct  aggggtagg  gctaggaac  gtacctcct  accacacga  cagcagtgg  120
gaagaagat  agggcagca  aggtggaga  gggagacga  aatagcagc  gcaatgggg  180
atcaatgtc  cagagacag  cactcggtc  tcccccaat  cctagctag  gcccctatg  240
cttggggtg  aagaggtaa  tcccacccc  ggtccctcc  ctcagacag  ctcctcagg  300
ctcaaccca  ttnttctgt  aggagactc  ggcacatgg  agaggagga  gtgggggga  360
gagactttg  gagaggcag  gtntggtag  atnaaggca  aagtggggg  gcattagca  420
ggttttaac  ctgccattc  cacca  445



<210> 7539
<211> 1241
<212> DNA
<213> Homo sapiens
<308> AK024220
<400> 7539

gtgctcggc  ttgagctcc  gcagccgcc  ccgctgcag  ggtcgtccc  gccctcccc  60
gccccgggg  gcaccccgc  aggctcccg  tggtgtccc  ggagcatgg  aggctgctg  120
gcgtgagtg  cggtgtctg  caggagctg  gtggcaggg  gggcgtcca  ggctgcagc  180
aacaagggc  acaagccca  agtccggag  atccgcttt  cggcaggcc  cgatgcaga  240
ggatcccac  gccacgtcc  ctttgatga  aagctgcat  actcggtgg  catggtcac  300
caggagagt  acagcagct  tctggtcaa  gttggcttc  tgaagatcc  gcacaggta  360
gagattacc  tcactctgc  cccagtgca  aggctgagc  aggatgtcc  cgaggcacc  420
gtccccagc  tgcacctca  gctcctcag  gtggtgccc  tccctgaag  ttatagtgt  480
aagtgtgag  actcggcgc  caaagaggg  gtcctcaaa  aggagatac  gctagcctg  540
gaaggtggc  ctggcacct  tgtgcgcgt  acggtgcag  cccgcgtca  ggaccggca  600
cacggcacg  ccatgctgc  ggatggtgt  aagtgtgtg  gcgccgagc  ggaatacga  660
tcagagcac  gcgactggc  cggctttga  tgaggcccg  ggccccgcc  gccccgggc  720
cctcagcct  aaaccccgc  ttgtccccc  gacatgctg  gtgatggtg  ggcttcctc  780
cccctctct  gggtgggtg  gggggtgga  tggccttgc  cacgcctct  acctctgcc  840
tcatttgtg  tgccaccct  cccctccct  gtcctcctc  cccacttcc  cctctctgt  900
tgcctcagt  tcctgccgg  agaaatggg  tgagcccga  aggaggctg  ctgaggaag  960
gagagggag  gcctggggt  ggtccccca  tccccaccc  aagccacag  gactcccac  1020
agggtctgg  agaggacgg  gctggctct  tggcgtcgt  gccccatta  tgctgcctt  1080
cttcagcca  ctctcctgc  cctccctag  ccccactgc  gtccaccat  agtaggagg  1140
aggtgcagt  cccagcccc  acccctcag  tctgtgtta  ttggttttt  agcgactgg  1200
tgggataga  ccctaaaga  ataaacttc  agtggatac  g  1241



<210> 7540
<211> 175
<212> PRT
<213> Homo sapiens
<308> AK024220
<400> 7540

Met Ala Ala Ala Asn Lys Gly Asn Lys Pro Arg Val Arg Ser Ile Arg 
  1               5                  10                  15
Phe Ala Ala Gly His Asp Ala Glu Gly Ser His Ser His Val His Phe 
             20                  25                  30
Asp Glu Lys Leu His Asp Ser Val Val Met Val Thr Gln Glu Ser Asp 
         35                  40                  45
Ser Ser Phe Leu Val Lys Val Gly Phe Leu Lys Ile Leu His Arg Tyr 
     50                  55                  60
Glu Ile Thr Phe Thr Leu Pro Pro Val His Arg Leu Ser Lys Asp Val 
 65                  70                  75                  80
Arg Glu Ala Pro Val Pro Ser Leu His Leu Lys Leu Leu Ser Val Val 
                 85                  90                  95
Pro Val Pro Glu Gly Tyr Ser Val Lys Cys Glu Tyr Ser Ala His Lys 
             100                105                110
Glu Gly Val Leu Lys Glu Glu Ile Leu Leu Ala Cys Glu Gly Gly Thr 
         115                120                125
Gly Thr Cys Val Arg Val Thr Val Gln Ala Arg Val Met Asp Arg His 
     130                135                140
His Gly Thr Pro Met Leu Leu Asp Gly Val Lys Cys Val Gly Ala Glu 
 145                150                155                160
Leu Glu Tyr Asp Ser Glu His Ser Asp Trp His Gly Phe Asp Ter 
                 165                170                175



<210> 7541
<211> 373
<212> DNA
<213> Rattus norvegicus
<308> H31897
<400> 7541

aattggaat  cactttaat  atttttaag  gacatatgg  actgtaagg  caggaagga  60
aaagtcaca  agtccacaa  ctcgtgaag  tgtcagctc  aaaggctag  agtcactgc  120
ctgttggnt  gacgctcac  gtaaacgtt  tgtaacgaa  gcatgttga  tttagtgtc  180
ttcattaca  agcagaggg  gtttctctt  tttggtcac  tgtttttca  ttaagaaat  240
ttttaaaaa  ggtattcac  ttttatttc  acacgttca  tgggcatct  caaaaccag  300
agcttctca  angaaatca  ccagggttg  aaacataag  tacaaggtt  tgactcccg  360
cactcaggt  tcg  373



<210> 7542
<211> 469
<212> DNA
<213> Homo sapiens
<308> AA033555
<400> 7542

aaaagaaca  tcgaaatga  caactcacc  taccctctg  ccctgatta  acaggatca  60
ttgtaaagt  agggcttct  catgacacc  tagttctgc  caatactgc  tttgggata  120
gaaattcta  acttggatg  ctcgcttca  aataaaaca  agcttaaaa  taaaataac  180
gaaagaaat  gaattcagc  aatagttat  ttttgcact  gaactgaaa  gtactgtac  240
gtanattat  actcatttt  agtgacctt  aaaatcaga  gtatttatt  tgcttgtgt  300
attatagaa  taaagaaat  ggtgacagg  ttaacctca  ctatgaatg  acagtatgt  360
gatttgtga  actgactgt  ggaagtcaa  aacttgtac  gtgtcttgt  tttacagtt  420
tgatttatt  ctttganaa  cctgctgtt  tgggaaatg  acagttgaa  469



<210> 7543
<211> 397
<212> DNA
<213> Rattus norvegicus
<308> H31914
<400> 7543

cttgcaaaa  gaganactt  aattattta  agcaaaggc  caagtaaac  ttttaggtt  60
tacagtgtt  caattaaga  aacccaaca  tacaatgaa  tacatttat  actttgcat  120
tccaatgta  taccgtgcc  cctcttctc  ggaaggaag  ggtatgtag  tccatgggt  180
taatgtaaa  agttggatt  taaatagca  ctgcctact  tactgtcaa  aagaaattt  240
aattaattt  agaattaat  agaaattaa  taaaaattg  ttgctcatc  agagtagca  300
taactttca  gctgaaact  actgcttta  tgagttact  actctgcat  cgntagcca  360
caatgtctt  ggtgttgtg  agtgaccat  cttgacc  397



<210> 7544
<211> 712
<212> PRT
<213> Rattus norvegicus
<308> P13383
<400> 7544

Val Lys Leu Ala Lys Ala Gly Lys Thr His Gly Glu Ser Lys Lys Met 
  1               5                  10                  15
Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu Met 
             20                  25                  30
Ser Glu Asp Glu Asp Asp Ser Ser Gly Glu Glu Glu Val Val Ile Pro 
         35                  40                  45
Gln Lys Lys Gly Lys Lys Ala Thr Thr Thr Pro Ala Lys Lys Val Val 
     50                  55                  60
Val Ser Gln Thr Lys Lys Ala Ala Val Pro Thr Pro Ala Lys Lys Ala 
 65                  70                  75                  80
Ala Val Thr Pro Gly Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys Ala 
                 85                  90                  95
Val Thr Pro Ala Lys Val Val Pro Thr Pro Gly Lys Lys Gly Ala Ala 
             100                105                110
Gln Ala Lys Ala Leu Val Pro Thr Pro Gly Lys Lys Gly Ala Val Thr 
         115                120                125
Pro Ala Lys Gly Ala Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp Ser 
     130                135                140
Asp Glu Asp Glu Asp Glu Glu Asp Glu Asp Asp Ser Asp Glu Asp Glu 
 145                150                155                160
Asp Glu Glu Asp Glu Phe Glu Pro Pro Val Val Lys Gly Val Lys Pro 
                 165                170                175
Ala Lys Ala Ala Pro Ala Ala Pro Ala Ser Glu Asp Glu Asp Glu Glu 
             180                185                190
Asp Asp Asp Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Glu Glu Glu 
         195                200                205
Glu Asp Asp Ser Glu Glu Glu Val Met Glu Ile Thr Pro Ala Lys Gly 
     210                215                220
Lys Lys Thr Pro Ala Lys Val Val Pro Val Lys Ala Lys Ser Val Ala 
 225                230                235                240
Glu Glu Glu Glu Asp Asp Glu Asp Asp Glu Asp Glu Glu Glu Asp Glu 
                 245                250                255
Asp Glu Glu Asp Glu Glu Asp Asp Glu Asp Glu Asp Glu Glu Glu Glu 
             260                265                270
Glu Glu Pro Val Lys Ala Ala Pro Gly Lys Arg Lys Lys Glu Met Thr 
         275                280                285
Lys Gln Lys Glu Ala Pro Glu Ala Lys Lys Gln Lys Ile Glu Gly Ser 
     290                295                300
Glu Pro Thr Thr Pro Phe Asn Leu Phe Ile Gly Asn Leu Asn Pro Asn 
 305                310                315                320
Lys Ser Val Ala Glu Leu Lys Val Ala Ile Ser Glu Leu Phe Ala Lys 
                 325                330                335
Asn Asp Leu Ala Ala Val Asp Val Arg Thr Gly Thr Asn Arg Lys Phe 
             340                345                350
Gly Tyr Val Asp Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala Leu Glu 
         355                360                365
Leu Thr Gly Leu Lys Val Phe Gly Asn Glu Ile Lys Leu Glu Lys Pro 
     370                375                380
Lys Gly Arg Asp Ser Lys Lys Val Arg Ala Ala Arg Thr Leu Leu Ala 
 385                390                395                400
Lys Asn Leu Ser Phe Asn Ile Thr Glu Asp Glu Leu Lys Glu Val Phe 
                 405                410                415
Glu Asp Ala Val Glu Ile Arg Leu Val Ser Gln Asp Gly Arg Ser Lys 
             420                425                430
Gly Ile Ala Tyr Ile Glu Phe Lys Ser Glu Ala Asp Ala Glu Lys Asn 
         435                440                445
Leu Glu Glu Lys Gln Gly Ala Glu Ile Asp Gly Arg Ser Val Ser Leu 
     450                455                460
Tyr Tyr Thr Gly Glu Lys Gly Gln Arg Gln Glu Arg Thr Gly Lys Asn 
 465                470                475                480
Ser Thr Trp Ser Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser 
                 485                490                495
Tyr Ser Ala Thr Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr 
             500                505                510
Phe Ile Lys Val Pro Gln Asn Pro His Gly Lys Ser Lys Gly Tyr Ala 
         515                520                525
Phe Ile Glu Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser 
     530                535                540
Cys Asn Lys Met Glu Ile Glu Gly Arg Thr Ile Arg Leu Glu Leu Gln 
 545                550                555                560
Gly Pro Arg Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu 
                 565                570                575
Phe Val Lys Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu 
             580                585                590
Ser Phe Glu Gly Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr 
         595                600                605
Gly Ser Ser Lys Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp 
     610                615                620
Ala Lys Ala Ala Lys Glu Ala Met Glu Asp Gly Glu Ile Asp Gly Asn 
 625                630                635                640
Lys Val Thr Leu Asp Trp Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly 
                 645                650                655
Gly Arg Gly Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg 
             660                665                670
Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly 
         675                680                685
Arg Gly Gly Phe Arg Gly Gly Arg Gly Gly Gly Gly Asp Phe Lys Pro 
     690                695                700
Gln Gly Lys Lys Thr Lys Phe Glu 
 705                710



<210> 7545
<211> 10942
<212> DNA
<213> Homo sapiens
<308> M60858
<400> 7545

attctgctg  agacataga  atgatgatc  tagctgact  tgatgatga  cccccgcga  60
cctgaaaga  gaaatgctc  ggtttgcta  gcccgcgaa  cgagtgaga  ccacccaca  120
agctaaccg  ggaagtcac  ggcggcctc  ttcgccctg  cagccgggg  acccatccg  180
tggctctcg  cctgctccc  ggccatctg  tgacactga  ttcgcagcc  ccaccttaa  240
tggcgcatt  gacccaaat  ataacctgg  aacctgtgg  cggtctaag  cccggctct  300
cggtcgccc  cccaggccc  tctccctgg  cctgtgagg  cagaaagtt  cttctccga  360
gccagttcc  catgtctga  aaatatctc  caacttgag  ttctgtggg  taggggagg  420
ttcgtgact  tctcacaga  aacctcgta  agaccccgc  actgccttt  ttaacagct  480
tcaggagac  gcctgcagg  ggggggtcg  tccggcccc  tgctcgcgg  caagcaggg  540
taagctgtg  ctccaaaag  gccaacggg  actccgcgg  ccctgaact  ccggtgctg  600
aggactcct  gctccaggg  caccaggag  cgcggcgtg  gtgcgtgcc  gaaccgagg  660
cggggtctc  gaggaactc  aaggctgcc  aagcctacg  acccagcca  attggcgaa  720
cggagaccg  ccgattcca  cacccccgc  ctcccctca  agccggcgc  aaaaacgcc  780
gtcccacga  gcaggccgg  acccgcgcg  ccacggccc  atcagcgcg  ccttgcaca  840
agcgagccc  gcccccacg  cgccgttgc  agcccctcc  cctcccgtg  cgcctcggc  900
cgcctactc  ccgccccgc  ccgttcacg  ttagaggct  gcgattggc  catggggac  960
gccgcgagc  ttggttggt  ggcgcggag  cacgaggcg  cgtcgtcgc  tttccacag  1020
cgttactgg  caggctcag  ctttcgcct  agtctcgag  tctcgctgg  ttcgggtgt  1080
cgtgctccg  gatcttcag  acccgcggc  gccatcgcc  tcgcttggc  tcttctgga  1140
tcatctgcg  cacttgtcc  cttcacact  cgccgccat  atggtgaag  tcgcgaagg  1200
aaacggcct  gagcgcgac  cagacgtgt  ggcctgctt  cgaggggcg  gcgcggcgc  1260
gcggggagg  gggcctgcg  gcagtcccg  gcgcgttct  gggcgccat  ctgcgggaa  1320
tctcgcgcg  ttagtgggg  ggtctcgcg  ttctggcta  ttggtggcg  ggtgaagag  1380
ttctgcagg  gctggggga  ggggcgctg  gcctcgggg  ggagagatg  gaccaaact  1440
ttgcgacgc  tacgagctg  gactgactc  gacgcacgt  cccgggagc  tgcctgcca  1500
gtgggccgg  gtaggtctg  aatctccag  gggaccggg  gccttgggc  gggaaatgg  1560
ggtatcggc  ctagtcgga  tcccggctg  gctcggatg  ctccgcccc  gcctggcaa  1620
ccgatacgt  gtgggcccc  gaaggtggc  ctgccgcgt  ccttttgcg  tgtgtttcg  1680
gcaagaggt  gtcctgcca  gtaccccca  gtggccgca  ccgcctctt  aaggggcgg  1740
gtagtgctg  ggaaaggca  aagcttcat  agaaaataa  gtagtattt  taagtgcct  1800
aatgatctt  accgttaat  tgattcaaa  aagggtggt  gataaagta  cgggatttg  1860
agtataaaa  cacggttgt  cttaactaa  gtaacggga  gagaaatca  ttcctcagg  1920
tgacttttt  ccttagggc  ggttttctg  tggtaaagc  tgggaggaa  aatgtgggc  1980
gttgagaag  agtccctct  gcattgcca  caggagtag  ttctatgtt  gttgtggtg  2040
ttggcacta  gagaaatga  ctgagacgg  gatgatggc  tatgaacac  aatggcaaa  2100
tatgaatgg  ctgaaatgt  gaggtggag  tgtaatgat  tatttgtgt  cattttagg  2160
aggtaaaaa  caaggtgac  ccaagaaaa  ggctcctcc  ccaaaggag  tagaagaag  2220
tagtgaaga  gaggaaatg  cagaagatg  agaagatga  agcagtgga  aagaggtaa  2280
tttatccaa  ttaatgcag  attatgtta  aactacaaa  tggagagtt  agacatgaa  2340
ttggatatc  gtggcaaaa  taagatttt  tcaggtatg  cttattgta  tggttgagt  2400
tttcacaag  tcttcattg  catgtcaag  tgtcatttg  ctagtattt  aatgtgagt  2460
ctaagacga  actgggaat  tcttttaca  gttcctctg  agggcttgg  gtgtgattt  2520
ttgtgttaa  tcattacat  tttccagtt  caacatgtt  gctcacccc  acatgtaga  2580
ctgggcatt  tattcagag  tgagaataa  cttaccaga  tcctttcct  tcctccgaa  2640
taaaattaa  tggtctcca  tccatatat  tataactgt  tcactactg  ttaagtact  2700
gggtgtaga  tgagggctg  cacctctct  tggtaccat  gaccctctt  agccacctc  2760
tggcctttt  tttgcctcc  ctataaaga  agctgagca  tgaattgtg  tcaggtttt  2820
gttgagaac  tgaatgaaa  ttttactct  cacacattg  cttgataaa  ctacgggat  2880
ttaatgtag  taaatgatg  cttttatca  actaccatg  acactcttt  atgtgtgat  2940
gttttgtaa  gaatattta  atttagcct  ttcattttt  gtctcaggt  ctaagaatt  3000
agcttcact  ggcttggtg  accgcaacc  cgagggccc  aatgattta  taagttaat  3060
cttggagcc  cctatgtgt  acgttctga  taatttaca  atagcaatt  atgacctta  3120
acatgtaag  atgatacta  taccatttt  agatgagaa  gttggggct  gggaaagta  3180
gaggtgtaa  aattcagag  gtctggttc  gaggtattt  cagtgttca  aagagttcc  3240
tatgtctgg  tattcacct  attataggg  ctctgactt  agacaacat  acagaagcc  3300
ggagtttta  catgtcata  gtgtcatgc  tatgtcttg  accagaggc  ttgccagag  3360
ctaacaact  attgggacc  tggttatct  tttgggtgt  gggctggac  tactggttt  3420
gttttcatt  atctcaagg  cgtcatacc  cagaagaaa  gcaagaagg  tgctgcaac  3480
tcagcaaag  aggtggtcg  ttccccaac  aaaaaggtt  cagttgcca  accagccaa  3540
aaagcagct  tcactccag  caaaaaggc  gcagcaaca  ctgccaaga  gacagttac  3600
ccagccaaa  cagttacca  acctggcaa  aagggagcc  caccaggca  agcattggt  3660
gcaactcct  gtaagaagg  tgctgccat  ccagccaag  gggcaaaga  tggcaagaa  3720
gccaagaag  aagacagtg  tgaagagga  gatgatgac  gtgaggagg  tgaggagga  3780
gacgaggac  aggatgagg  tgaagatga  attgaacca  cagcgatga  agcagcagc  3840
gctgcccct  cctcagagg  tgaggacga  gaggatgac  aagatgatg  ggatgacga  3900
gacgatgag  aagatggta  ggagttgtc  tggtagtta  tgggcttct  attacaagg  3960
atcttgaga  tctgggatc  catattcct  catcgtaca  cctggagat  agattagaa  4020
cttgtggga  ttctcttgg  ttgttgtgg  gtgctagac  taattaccc  tgaatgatt  4080
tgtcctctt  agaaaattt  aatagcaca  ctattagtg  tttttataa  gtaggattt  4140
cgtttctaa  tgatttttt  tttttttta  atttttttg  gatggagct  ttgctgttt  4200
ccaggcggg  gtgcaatgg  gcgctatct  ggcgcactg  agcctccat  tcctgggtt  4260
aagcagttc  gcctcagcc  cccgagtag  gggattaca  gtgcccacc  ccacaccct  4320
ctaattttg  attttagta  agacgacat  tcaccatgt  ggccaggct  gctctgaac  4380
ttgacctca  gtgatccac  caccttagg  tctcccaaa  tgctaggat  acaggtgag  4440
tatgctgcg  ccggcccca  gtgatctat  cttgccatg  ctgttaact  aacatggtg  4500
caggattcg  ttttcttta  attagattt  aaaaccgat  ttggttttg  gagattgct  4560
caattttta  gtgacttct  tttcagact  tgaagaaga  gctatggag  ctacaccag  4620
caaaggaaa  aaagctgca  aagttgttc  tgtgaaagc  aagaacgtg  ctgaggatg  4680
agatgaaga  gaggatgat  aggacgagg  tgacgacga  gacgaagat  atgaagatg  4740
tgatgatga  gatgatgag  aggaggaag  agaggagga  gaaggtact  aaattagat  4800
ctgacatac  acatgagtt  tgtttaaag  aggcactta  gtgtttgtg  ctactgatg  4860
gtgatacat  gtttgacat  ttgtccaga  cctgtcaaa  aagcacctg  aaaacgaaa  4920
aaggaaatg  ccaaacaga  agcagctcc  gaagccaag  aacagaaag  ggaaggtaa  4980
ttgcagaat  aggggatat  ggggagata  acagcacaa  tgatgaata  caaagggac  5040
taatactga  accagatgt  acattgtag  gtgctgatg  gctgtgtat  gaaattttg  5100
tttggaaac  aacttttta  cacactaca  gtagactga  ttgagcttt  tttgtgcag  5160
cacagaacc  actacggct  tcaatctct  tgttggaaa  ctaaacttt  acaaatctg  5220
tcctgaatt  aaaactggt  tcagcgatg  ttttgctaa  aatgatctt  ctgttgtgg  5280
tgtcagaat  ggtatgact  ggtagctgc  tcactgcac  ttacatacc  tgggtctgt  5340
aatttttcc  tcccctgtt  gcacagtta  tttagcctg  cactgttaa  catgaatac  5400
gtaaacact  caaggttag  attagtgaa  taagttaga  ttaaactgt  gatccccta  5460
gttgcaatt  ccataatca  tcgtaactt  gtatagcac  gaataattt  tagtaattt  5520
tttgttgtt  ttgttatgt  ttgagacgg  cgctggctt  tgttcaggc  ggagtacag  5580
ggcgcaatc  tggctcact  caacctctg  ctcccgggt  caagcgatt  tcctgccta  5640
cctcccaag  gactgggat  cgggtgcca  tcaccatgc  tggctaatt  ttgttttgt  5700
tttagtatc  atttcacca  gttggtcgg  tggttttga  ctcctgacc  caagtgatc  5760
acccacctc  gcctctcga  gtgctggta  agcgtcacc  ccctgccag  aagttttaa  5820
aatttggtg  taggtggga  aatgcttga  cctgggagg  agaggttgc  gtgagccaa  5880
ttcgcgcca  tgtactcca  cctgggcaa  agattgaga  accgtctca  tttaaaata  5940
tgtttattt  cttggaagt  ccttgaaac  attagacct  tctagtcat  atagtgaat  6000
cttttatcc  gacaggatt  tcctgtatt  gtgcttata  gtgttcttt  gtcagctgc  6060
actgtgaat  cttataagc  atttagctc  atgatgaag  cctcaaacg  gaatgtgca  6120
gtcatatct  catgctgag  cgtgttctg  agctgcagt  tgcagagcc  tgactttgt  6180
ttgctatac  aggggtgct  tttaaaatg  gatctttgt  tgcaccatc  catttgtct  6240
gatacagat  gtgattttg  tttgtgttt  cacctgttg  aattttgcc  tcctctcca  6300
ctgaaggaa  tttggttat  tggattttg  atctgctga  gacctggag  aagcgttgg  6360
actcactgg  ttgaaagtc  ttggcaatg  aattaaact  gagaaacca  aaggaaaag  6420
cagtaagaa  ggtatgtaa  gctttatga  ttatgcaat  aactcagga  ctagactgc  6480
agggaaaat  ctttgtaac  catttccct  tggtttcct  ttatttttt  taaatcatt  6540
ttttccttt  gtttcctct  aatgtggga  ttaaatgag  tacagtgtt  acaaggtac  6600
tggcactgc  tgtcagtgt  taggtaaat  cctgagtta  gcaagcaag  gcactctta  6660
acagaacaa  aaccattac  tgcacctaa  ttaagctaa  gatctttct  cactgaaac  6720
agttaggtc  ctaattact  cctatatac  gtgtaatgt  ttgaattgg  acattcact  6780
tttttgtta  gcgcgtcta  tctaggttg  actccagtg  acctaacag  gagtttgac  6840
tcaaggctg  gacaacatg  agggaccac  tgtgtgttg  cactgctat  tctccatat  6900
tagcaccga  ccttgtaca  ataggatct  aaattattt  ttgatagag  tatgtgtgt  6960
tttcccctc  ttttgttgt  gccccccac  tttggtttt  caggccaca  agctcattt  7020
tgttttttt  atctagagc  agatgcgag  acacttttg  ctaaaaatc  cccttacaa  7080
gtcactcag  atgaattga  agaagtgtt  gaagatgct  cggagatca  attagtcag  7140
aaggatggg  aaagtaaag  gtatgttct  ctattgaaa  gtaagggtt  tattaacat  7200
aatgcactt  ctgctttat  aaagaaata  tggtttgat  tccttaggc  tgtaacttg  7260
acagtttaa  ctgtaagtt  gtgcctcag  aacccatct  taccatggg  ataatgtac  7320
catagggtg  ttttaaaag  caaagctaa  acttacaaa  aagcaagtt  aatgcctat  7380
ttacataaa  actttgtaa  tagtagcag  tctttcagt  aggtgaggt  acatgaaaa  7440
attccaagt  tttgtaaaa  tagtgggaa  taagaggga  gctcgagtt  tgattgaaa  7500
gtggactaa  caagggcat  ttatgtact  agatctgaa  caagttctg  gttgctgag  7560
taaaagcat  tgtgttaat  tggttttaa  aaccatgag  tcttctccc  ccattgcag  7620
attgcttat  ttgaattta  gacagaagc  gatgcagag  aaacctttg  agaaaagca  7680
ggaacagag  tcgatgggc  atctatttc  ctgtactat  ctggagaga  aggtcaaaa  7740
caagactat  gaggtggaa  gaatagcac  tggagtggt  agaaattag  cttgttcca  7800
ggttttcag  attggttga  ggaactctt  tagtctttg  atttcataa  tttataaat  7860
ctttttaat  aaagttact  aaatgtagg  gaagatcaa  gacatgata  cccaagtca  7920
actcttatt  ggaatagta  tttccaatc  tgaaatgag  gctctaaat  attttgcat  7980
ggaatacag  aggcaaatc  agcttcctt  gtaggcatg  tttatactt  aaatgactt  8040
accatgtgc  ttttgaact  agatgattc  aggaaaaca  accagtcat  agcctatgt  8100
agaacaacc  gcaggacat  gcaacacgt  ctaggtact  aatatgttg  gtaacagaa  8160
tggatttag  ttacgtcat  agtatttgt  tataactca  gcactgaaa  tcttaggga  8220
tagatatta  tgttgtgac  gaagctggg  cactgtttc  gagtcttag  aatgtggct  8280
tctatttcg  ggtgaatca  aaactctgg  tttaagcaa  ctctcctac  gtgcaacag  8340
agaaactct  caggaagta  ttgagaaag  aacttttat  aaagtaccc  agaaccaaa  8400
tggcaaatc  aaagggtaa  ataatacct  tgtatcatc  gttataggc  tatatatgt  8460
ttagaggtc  aaggacgta  ggtcatgtg  cctgtagaa  aaagctaaa  aattttagc  8520
tagtaaatg  gtgtaaaat  agtatattt  ggtccaacc  tgagagaag  gccttggcc  8580
gatcatgtg  ccagtggta  agagagcat  tgcctggta  attactcta  gcattaact  8640
ttcatcctc  ggtatgcat  tatagagtt  gcttcattc  aagacgcta  agaagcttt  8700
aattcctgt  ataaaaggg  aattgaggg  agagcaatc  ggctggagt  gcaaggacc  8760
aggggatca  ctaatgcca  aagccgtaa  ttcacctgg  tagggtgct  tggttgggg  8820
tagcactct  ggtgctttg  ttatttttg  acaaattct  tgtttcctg  tcgctactg  8880
gtgaacaat  actggatat  gatgactga  tacctgaga  ataattgat  aaatctcaa  8940
aaaattcct  tagatagtc  agttctgat  cagctgtcg  caactcaga  tagcaagtt  9000
gcccatgat  tcctgcccc  tccactggg  cccacctgc  tgggttgct  tcccacttt  9060
catagaaga  tggggcagg  tatcaacta  gcaatggca  ttaaaaaat  taaacccag  9120
atagccttt  ctttaatta  ggactagtt  gcttagttg  ttttaactg  tttttcact  9180
taacaagta  cttggctag  agtcatact  ggcattgtg  aaattcagt  tacgaactg  9240
gaattcaca  aaatcgcaa  ttttttttt  cttcccaga  ccatccaaa  ctctgtttg  9300
caaaggcct  tctgaggat  ccactgaag  gacattaaa  gagtcattt  acggctccg  9360
tcgggcaag  atagttact  accgggaaa  tgggtcctc  aaagggtaa  ggaaggaag  9420
gtgagtgct  cttccactt  aaggggttt  tgttctgtg  agaccttga  tctaatgtg  9480
cttctcatt  agctccttc  gtctatcag  ggcagttta  ggattcgca  gagaagaag  9540
gagaattca  agaactagc  ttattttac  ttctgtctt  acagaggta  atttagctg  9600
attgtgaga  attctgggg  tcaagctgt  acaccagtt  gttttccat  gagagctac  9660
ctgctgcac  ggtatcttt  tcccaaata  acaaggcta  ttctgtggg  tggctcccc  9720
gcatgtaca  ttaacttgg  acatgtgta  taggtgctt  ttataatgg  caatttcat  9780
tggtgttct  ggtttggtt  tgtagactt  aacagtgag  aggatgcca  ggaggccat  9840
gaagacggt  aaattgatg  aaataaagt  accttggac  gggccaaac  taagggtga  9900
ggtggcttc  ggggtcgtg  tggaggcag  ggcggcttt  gaggacgag  tggtggtag  9960
ggaggccga  gaggatttg  tggcagagg  cggggaggc  ttggaggta  ggcacgcag  10020
gataatgac  ccacatagc  tgtgctctt  agaccctgt  ccctgtcac  gttcctaat  10080
actggggag  aggagcttt  tacccattc  tttaacagt  tcttgcctt  ctcctgtag  10140
gcgaggagg  ttccgagga  gcagaggag  aggaggtga  cacaagcca  aaggaaaga  10200
gacgaagtt  gaatagctt  tgtccctct  ctttccctt  tccatttga  agaaaggac  10260
ctggggttt  tactgttac  tgatcaatg  cagagcctt  tgaggacat  ccaagacag  10320
atacagtcc  gtggtctcc  tggaaatcc  tctagttaa  atttcaagg  caataccgt  10380
ttggttttg  ctggatatt  atataaact  tttaaagag  tgagtgata  agctaaccc  10440
tatctgtaa  ttttgaatt  atattgttt  atcccatgt  caaaaccat  ttttcctac  10500
aatagtttg  gttttgttg  tgttacttt  ttttttgtt  ttgtttttt  tttttttgc  10560
ttcgtgggg  tgtaaaaga  aagaaagca  aatgtttta  catggtttt  gcttcaccg  10620
tttaggaca  attaaaagt  aactctggt  ccagacgtg  tacttccta  agagtgttt  10680
ccctggaat  tcactggag  gcatggcaa  gccagctct  ccacttgct  cacccatcc  10740
aatggaaat  gcttagtgc  tgtttccag  atcccagcc  taactaact  ggttgaaat  10800
ctggtgagg  gacctgctc  tgcagccct  gtgctgact  gaaggctgc  gcagcttct  10860
ctactttta  caggtctcg  ggattatgt  tgaagacca  tctggaaag  ggtcgagga  10920
cagattagt  aggtttcct  gg  10942



<210> 7546
<211> 706
<212> PRT
<213> Homo sapiens
<308> P19338
<400> 7546

Val Lys Leu Ala Lys Ala Gly Lys Asn Gln Gly Asp Pro Lys Lys Met 
  1               5                  10                  15
Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu Met 
             20                  25                  30
Ser Glu Asp Glu Glu Asp Asp Ser Ser Gly Glu Glu Val Val Ile Pro 
         35                  40                  45
Gln Lys Lys Gly Lys Lys Ala Ala Ala Thr Ser Ala Lys Lys Val Val 
     50                  55                  60
Val Ser Pro Thr Lys Lys Val Ala Val Ala Thr Pro Ala Lys Lys Ala 
 65                  70                  75                  80
Ala Val Thr Pro Gly Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys Thr 
                 85                  90                  95
Val Thr Pro Ala Lys Ala Val Thr Thr Pro Gly Lys Lys Gly Ala Thr 
             100                105                110
Pro Gly Lys Ala Leu Val Ala Thr Pro Gly Lys Lys Gly Ala Ala Ile 
         115                120                125
Pro Ala Lys Gly Ala Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp Ser 
     130                135                140
Asp Glu Glu Glu Asp Asp Asp Ser Glu Glu Asp Glu Glu Asp Asp Glu 
 145                150                155                160
Asp Glu Asp Glu Asp Glu Asp Glu Ile Glu Pro Ala Ala Met Lys Ala 
                 165                170                175
Ala Ala Ala Ala Pro Ala Ser Glu Asp Glu Asp Asp Glu Asp Asp Glu 
             180                185                190
Asp Asp Glu Asp Asp Asp Asp Asp Glu Glu Asp Asp Ser Glu Glu Glu 
         195                200                205
Ala Met Glu Thr Thr Pro Ala Lys Gly Lys Lys Ala Ala Lys Val Val 
     210                215                220
Pro Val Lys Ala Lys Asn Val Ala Glu Asp Glu Asp Glu Glu Glu Asp 
 225                230                235                240
Asp Glu Asp Glu Asp Asp Asp Asp Asp Glu Asp Asp Glu Asp Asp Asp 
                 245                250                255
Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro Val 
             260                265                270
Lys Glu Ala Pro Gly Lys Arg Lys Lys Glu Met Ala Lys Gln Lys Ala 
         275                280                285
Ala Pro Glu Ala Lys Lys Gln Lys Val Glu Gly Thr Glu Pro Thr Thr 
     290                295                300
Ala Phe Asn Leu Phe Val Gly Asn Leu Asn Phe Asn Lys Ser Ala Pro 
 305                310                315                320
Glu Leu Lys Thr Gly Ile Ser Asp Val Phe Ala Lys Asn Asp Leu Ala 
                 325                330                335
Val Val Asp Val Arg Ile Gly Met Thr Arg Lys Phe Gly Tyr Val Asp 
             340                345                350
Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala Leu Glu Leu Thr Gly Leu 
         355                360                365
Lys Val Phe Gly Asn Glu Ile Lys Leu Glu Lys Pro Lys Gly Lys Asp 
     370                375                380
Ser Lys Lys Glu Arg Asp Ala Arg Thr Leu Leu Ala Lys Asn Leu Pro 
 385                390                395                400
Tyr Lys Val Thr Gln Asp Glu Leu Lys Glu Val Phe Glu Asp Ala Ala 
                 405                410                415
Glu Ile Arg Leu Val Ser Lys Asp Gly Lys Ser Lys Gly Ile Ala Tyr 
             420                425                430
Ile Glu Phe Lys Thr Glu Ala Asp Ala Glu Lys Thr Phe Glu Glu Lys 
         435                440                445
Gln Gly Thr Glu Ile Asp Gly Arg Ser Ile Ser Leu Tyr Tyr Thr Gly 
     450                455                460
Glu Lys Gly Gln Asn Gln Asp Tyr Arg Gly Gly Lys Asn Ser Thr Trp 
 465                470                475                480
Ser Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser Tyr Ser Ala 
                 485                490                495
Thr Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr Phe Ile Lys 
             500                505                510
Val Pro Gln Asn Gln Asn Gly Lys Ser Lys Gly Tyr Ala Phe Ile Glu 
         515                520                525
Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser Cys Asn Lys 
     530                535                540
Arg Glu Ile Glu Gly Arg Ala Ile Arg Leu Glu Leu Gln Gly Pro Arg 
 545                550                555                560
Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu Phe Val Lys 
                 565                570                575
Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu Ser Phe Asp 
             580                585                590
Gly Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr Gly Ser Ser 
         595                600                605
Lys Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp Ala Lys Glu 
     610                615                620
Ala Met Glu Asp Gly Glu Ile Asp Gly Asn Lys Val Thr Leu Asp Trp 
 625                630                635                640
Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg 
                 645                650                655
Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Gly Phe 
             660                665                670
Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Phe Arg Gly 
         675                680                685
Gly Arg Gly Gly Gly Gly Asp His Lys Pro Gln Gly Lys Lys Thr Lys 
     690                695                700
Phe Glu 
 705



<210> 7547
<211> 270
<212> DNA
<213> Rattus norvegicus
<308> H31955
<400> 7547

acaacttga  tacaaacat  tatttatca  atccaaaat  taaaaacaa  gacttgcaa  60
actgcccag  ctcattttg  actacagag  tcaagtgat  ctcccacac  agactcctg  120
gtagctggg  tcagagtaa  tatacatgc  ccactgggc  cagcaacaa  atcaacttc  180
tataaatcc  ctagagagc  aagtcaatg  ttctaagta  agaactgta  gccactaag  240
tcaaggcca  cctggnctc  acccagcaag  270



<210> 7548
<211> 219
<212> DNA
<213> Rattus norvegicus
<308> H31964
<400> 7548

agttttagg  catttaatt  acacttgat  tgcatatga  tgggaaaac  ggagcnagg  60
tggagggtg  ttccctgag  tggggaccc  gagagtgat  ctgacagat  ggacccttg  120
tagaaagac  cattcctga  ataagctgt  attcccatg  tgactgggt  ggtggagac  180
tctccaaga  cccagatgt  agcacagtc  gttgggatt  219



<210> 7549
<211> 2112
<212> DNA
<213> Homo sapiens
<308> AK025590
<400> 7549

ttgatgcga  ccaaagata  agcggtggg  tctctgctg  cagctctcc  agcccctca  60
cttcgcagc  tggcgcagc  tcctctgag  ccccggggc  tgttggggc  gggttggaa  120
agccgtctg  agctacttc  gaggagctg  ttatccctc  ccacgcggg  cagactctg  180
cgggtctcc  agcgtccga  agatggctt  tttttctac  gtatttaaa  tggatgcag  240
cctaactgc  aaagtcaga  aggctgaca  ggaccaatg  ttctttatc  ggtgctcag  300
tctcagtca  acgtgcagc  tggctgcag  gtggaccag  tgcctggca  tcaggccca  360
atgcctgca  ggctggggc  ctcgggaca  atgcaggga  gtgtgctgc  gggctgctg  420
gaggagagt  gtgggggcc  gagggctga  tgattctgt  accacctga  accttcacg  480
ttgctgccg  tgggggctc  ggctgcact  cccgggtca  ctgacctgc  gcccagggg  540
ttccagtcc  gtctgtgtg  actggcacc  gggctgctg  agaagtctc  tcccgttcg  600
accagcctc  gggctgcac  ttacctcag  aatgggccc  accatgaag  ggcccatct  660
tcagcagcg  cttctaggt  cccagctca  ggagccatc  ccagctcca  ttttctcat  720
cgaatatgc  cagttttaa  tcacgttgt  acactagcc  gccgatgag  cccagacac  780
ggcagacct  gcgctcttg  cccctgatt  cagtgagga  tggccctga  gagtccttg  840
agacctgct  cctgcccca  gacaggccc  aagatggac  ccccctggc  ttgtgacag  900
tccccaagt  ttctccggt  gagaaactg  agaggactg  tgggcgggg  tccccagcc  960
tcaccatcc  gtgtacaat  gctgtagac  tgtatatgg  tcctttaat  ttgtaaaga  1020
gctgatgta  aattgtcgt  catttgtgt  aacacattg  gttcccagt  catgccata  1080
atgatgctc  caagcaaaa  actggaggc  ctgtcctgt  cagaagcag  agccagact  1140
ccgcattcg  tgttgtgca  ggaggtttg  gggcggaac  gattcctcc  ttggatcct  1200
cagttccca  cgaggaata  cccgcagca  tggtggagg  aggtcagtg  ctgggtcct  1260
agcttggtg  tatttattg  atttgggtg  ctgtcccct  agggcagca  agattctga  1320
ttctgattc  cagtcccta  ccagatggg  actgggaaa  agacagaag  cgtctgggt  1380
cttttgaac  ctgtctcaa  tgtttggga  tttctctct  actattctt  ggttgggga  1440
gatgtcctc  ttagacccc  acgtaatgg  atgagaagg  ggcaggcag  ggctcagcc  1500
gccaggggg  accaagtca  gcagccagc  tgagacctg  agttcacct  agcacagaa  1560
gagatctca  tatgcctcc  tgtaaacag  ttcacatag  cctccaatt  caatgagac  1620
ttttgcatt  tttctcaaa  cccttatgt  ctaacccat  agaaccatt  tacctgccc  1680
ctaagggcc  ccagcttcg  cctgcctca  gggacagca  cacagacca  tggctccct  1740
tccaaggcc  cagagcaga  gccatccca  tgtacaatc  aatttgctg  acaaacttg  1800
taggtttct  tgcttagca  cgagcctat  gttagttgg  acatctgcg  tttggcatc  1860
gaggctccc  tctgagtgg  ggagaaagt  ttgtgttta  tagcaggaa  tcttgtgaa  1920
acagctcgc  gctgtgtat  tttatggat  tttctgata  aacagccag  atggttacc  1980
agtggtaga  attctcgaa  attctcaaa  tctcttttt  ggtaaatga  tgtgctaaa  2040
taaaattta  taataaaga  ggggaaaaa  gagtaactc  acctgaaaa  aaaaaaaaa  2100
aaaaaaaaa  aa  2112



<210> 7550
<211> 363
<212> DNA
<213> Rattus norvegicus
<308> H31982
<400> 7550

gtttgtnct  tttttcaga  ctggggacc  aacccaggg  cttgcgctt  ctaggcaag  60
gctctacca  tgagttaaa  ccccaaccc  aagactttc  tttaaaaag  cagtactct  120
cggattgaa  gattacaat  cttcaatcc  gatgaactc  ccatattac  ggaaccaca  180
actggagca  tactgggag  cagtgaagt  ggtgcctca  gatatgggg  tgttcccct  240
agccatggg  tatctgtga  tatgaccca  cacagtctg  atttatctg  gaagaaaaa  300
agctcataa  tctgtgtac  cacttaaca  accacagca  ttagactgc  ttaggtatt  360
ggg  363



<210> 7551
<211> 367
<212> DNA
<213> Rattus norvegicus
<308> H31990
<400> 7551

tttgaactc  gaattagac  gtttgtatt  taaaacaca  acaaatctg  accaattaa  60
tacaaagtc  aaagggaat  taaattaca  ttttngttt  caacggatg  tagtaaaac  120
ctaccgtca  ctcaccaca  acacaaaca  cagcttttc  atagagtct  ccaggcctc  180
ctcaccaat  ctaaggact  aaaaaataa  aagtacagc  ggctgcaca  gctctctca  240
ttcctcaca  tacacggat  gctgtacac  gaggtccat  gtacaggca  ctacagagt  300
agtacataa  atatatttg  aaaattctt  cacgcacga  cctacaatg  ctctcctcg  360
aggatac  367



<210> 7552
<211> 305
<212> DNA
<213> Homo sapiens
<308> AW016287
<400> 7552

ttttttttt  tttttttaa  acccgaatt  cacagtttg  attctaaaa  acatacaca  60
acacacaca  agaaatgtg  accaattaa  cacaataaa  ttcaaaggg  atataaatt  120
cagtttttc  ttttttaac  gacaatagt  aaatactac  gtcagctca  tatacacac  180
aatcatgaa  agcagcttt  cattaaggt  tccaatatc  tactcattt  ccaactcga  240
gtaatttaa  agaaaaaag  tacagcacg  tctacgcat  ctctctctc  tgctctcac  300
acaca  305



<210> 7553
<211> 396
<212> DNA
<213> Rattus norvegicus
<308> H32977
<400> 7553

aaaggtttg  cactttatt  aataagcnc  aaaattaca  acaaatcaa  agagtaaga  60
aaataaaca  tcagcaaaa  gtctctngg  agcatccag  accactgca  ttaaagtat  120
gcatagctg  ggtatcacc  tgctcgctc  ccccgtccc  aaggatggc  ggacaggga  180
atcagcttt  caaaccaaa  tgtcatcat  cattgctat  cctttcttt  ccatttaac  240
tacagngaa  acacttcaa  ggaatagac  aataagcca  gagctttat  gatgcagca  300
gcactttac  atgganccc  agagagcct  ccttctctg  gaagacagg  tgtctgtac  360
aactctcat  aggtttttt  cacttcaga  cccaag  396



<210> 7554
<211> 153
<212> PRT
<213> Rattus norvegicus
<308> BAB25561
<400> 7554

Met Ala Arg Asn Thr Leu Ser Ser Arg Phe Arg Arg Val Asp Ile Asp 
  1               5                  10                  15
Glu Phe Asp Glu Asn Lys Phe Val Asp Glu His Glu Glu Ala Ala Ala 
             20                  25                  30
Ala Ala Gly Glu Pro Gly Pro Asp Pro Cys Glu Val Asp Gly Leu Leu 
         35                  40                  45
Arg Gln Gly Asp Met Leu Arg Ala Phe His Ala Ala Leu Arg Asn Ser 
     50                  55                  60
Pro Ile Asn Thr Lys Asn Gln Ala Val Lys Glu Arg Ala Gln Gly Val 
 65                  70                  75                  80
Val Leu Lys Val Leu Thr Asn Phe Lys Ser Ser Glu Ile Glu Gln Ala 
                 85                  90                  95
Val Gln Ser Leu Asp Arg Asn Gly Ile Asp Leu Leu Met Lys Tyr Ile 
             100                105                110
Tyr Lys Gly Phe Glu Lys Pro Thr Glu Asn Ser Ser Ala Val Leu Leu 
         115                120                125
Gln Trp His Glu Lys Ala Leu Ala Val Gly Gly Leu Gly Ser Ile Ile 
     130                135                140
Arg Val Leu Thr Ala Arg Lys Thr Val 
 145                150



<210> 7555
<211> 347
<212> DNA
<213> Rattus norvegicus
<308> H33086
<400> 7555

gggaaaggg  tctncattg  acatttaat  gttcatgca  cacttggtg  cataaatag  60
ggatggggg  acagggcca  agaatccac  gatagtcca  agtgcaggc  agacacaca  120
ggccagggc  acacagcag  gagctgatg  tcagctgga  gggtcacct  gacgtgcac  180
gcggggcag  caaaggttg  tcacactgt  tcatgacat  ctggtcatc  agaggacac  240
gagcagttn  ggacactca  gtggccctc  ggcctggct  gctcatatc  cagtccact  300
ttgatggtt  agggatgtg  ggtcaagcc  ggtttcaat  cattatc  347



<210> 7556
<211> 351
<212> DNA
<213> Rattus norvegicus
<308> H33101
<400> 7556

cggagctgg  gactgaacc  agggccttg  gcttgcnag  caagcgctc  accactgag  60
taaatcccc  acccctaga  cagacactc  taagtggca  agtggtaac  gggctccta  120
agtgtcaga  ccctgacat  tttcttttc  gagacagag  gggccggat  gaggggaag  180
agcctctgc  ccttacctt  ctctgcaac  ctgagaaac  agaaaaaaa  acctgggac  240
atattaaga  tcccaaagt  aaactatat  gaagtgttt  ttttttaaa  tctagtacc  300
gagaacagg  cagacatga  agttactac  cacaagggg  agtgtccca  t  351



<210> 7557
<211> 381
<212> DNA
<213> Rattus norvegicus
<308> H33219
<400> 7557

cttttaaat  attttatta  tgtataagc  aaanggaaa  ttacacact  aaatctcaa  60
acccttggg  atgcatatt  acccgttag  ggttcttct  catgtctct  ctgcttcca  120
aggaattgc  ccaaacgtt  aaaacccac  gcttgtttt  ttgtttttt  actgtatat  180
cagcctaaa  catagcaat  taggattat  tcattttac  ctgtgcaaa  tcctcaaaa  240
atagtggta  gacagagca  aaagatctc  acaaatttc  ttttaagac  ttcatataa  300
tnggtcctt  tccaaatca  accaattaa  acaggcaca  tctctgtca  gcctccagt  360
acgncctga  agtgatccc  g  381



<210> 7558
<211> 422
<212> DNA
<213> Rattus norvegicus
<308> H33426
<400> 7558

aaagattta  tcatgcagt  tatgtatat  agtnctgtc  tcatacaca  cagaaggaa  60
cagacctca  agatggttg  nagccacta  ggggttgtt  ggaattgaa  ttaggacct  120
tggaagaac  actgggtgc  atcactcag  cccaggttt  tgggagaga  agtgtcctg  180
gtagcctat  actgattag  aatttgaat  tcttctgcc  ccacctacc  catgctggg  240
tgactgcta  gagttgtag  ttccagaaa  gatgaacat  aagaccttt  tgcttctgt  300
acagaagtt  aagaaccat  ggaacatta  tttggtttc  acaggatgg  gtttgttca  360
ggctgagag  ctcaagtga  caatttagc  gagtctgta  acaaacaga  ttaccactg  420
gg  422



<210> 7559
<211> 339
<212> PRT
<213> Rattus norvegicus
<308> NP_031824
<400> 7559

Met Trp Trp Ser Leu Ile Leu Leu Ser Cys Leu Leu Ala Leu Thr Ser 
  1               5                  10                  15
Ala His Asp Lys Pro Ser Phe His Pro Leu Ser Asp Asp Leu Ile Asn 
             20                  25                  30
Tyr Ile Asn Lys Gln Asn Thr Thr Trp Gln Ala Gly Arg Asn Phe Tyr 
         35                  40                  45
Asn Val Asp Ile Ser Tyr Leu Lys Lys Leu Cys Gly Thr Val Leu Gly 
     50                  55                  60
Gly Pro Lys Leu Pro Gly Arg Val Ala Phe Gly Glu Asp Ile Asp Leu 
 65                  70                  75                  80
Pro Glu Thr Phe Asp Ala Arg Glu Gln Trp Ser Asn Cys Pro Thr Ile 
                 85                  90                  95
Gly Gln Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
             100                105                110
Ala Val Glu Ala Ile Ser Asp Arg Thr Cys Ile His Thr Asn Gly Arg 
         115                120                125
Val Asn Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ile 
     130                135                140
Gln Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ser Gly Ala Trp Ser 
 145                150                155                160
Phe Trp Thr Lys Lys Gly Leu Val Ser Gly Gly Val Tyr Asn Ser His 
                 165                170                175
Val Gly Cys Leu Pro Tyr Thr Ile Pro Pro Cys Glu His His Val Asn 
             180                185                190
Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Arg Cys Asn 
         195                200                205
Lys Ser Cys Glu Ala Gly Tyr Ser Pro Ser Tyr Lys Glu Asp Lys His 
     210                215                220
Phe Gly Tyr Thr Ser Tyr Ser Val Ser Asn Ser Val Lys Glu Ile Met 
 225                230                235                240
Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Thr Val Phe 
                 245                250                255
Ser Asp Phe Leu Thr Tyr Lys Ser Gly Val Tyr Lys His Glu Ala Gly 
             260                265                270
Asp Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
         275                280                285
Asn Gly Val Pro Tyr Trp Leu Ala Ala Asn Ser Trp Asn Leu Asp Trp 
     290                295                300
Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Glu Asn His Cys Gly 
 305                310                315                320
Ile Glu Ser Glu Ile Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                 325                330                335
Gly Arg Phe 
             340



<210> 7560
<211> 1996
<212> DNA
<213> Homo sapiens
<308> NM_001908
<400> 7560

tccggcaac  ccaaccgct  cgctgcgcg  aggctgggc  gcaggctct  ggctgcagc  60
ctgggctgg  gtgcagtgg  gcgaccacg  ctcacggca  cctcagcca  ccagatgta  120
gcgatctgg  tcccacctc  gcctcccga  tagtggatc  aggatccgg  ttccaacat  180
tggcagctc  gggcctccc  ctgctgcct  ctggtgttg  ccaatgccc  gagcaggcc  240
tctttccat  ccctgtcgg  tgagctggt  aactatgtc  acaaacgga  taccacgtg  300
caggccggg  acaacttct  caacgtgga  atgagctac  tgaagaggc  atgtggtac  360
ttcctgggt  ggcccaagc  accccagag  gttatgttt  ccgaggacc  gaagctgcc  420
gcaagcttc  atgcacggg  acaatggcc  cagtgtccc  ccatcaaag  gatcagaga  480
cagggctcc  gtggctcct  ctgggcctt  ggggctgtg  aagccatct  tgaccggat  540
tgcatccac  ccaatgcgc  cgtcagcgt  gaggtgtcg  cggaggacc  gctcacatg  600
tgtggcagc  tgtgtgggg  cggctgtaa  ggtggctat  ctgctgaag  ttggaactt  660
tggacaaga  aaggcctgg  ttctggtgg  ctctatgaa  cccatgtag  gtgcagacc  720
tactccatc  ctccctgtg  gcaccacgt  aacggctcc  ggcccccat  cacggggga  780
ggagatacc  ccaagtgta  caagatctg  gagcctggc  acagcccga  ctacaaaca  840
gacaagcac  acggataca  ttcctacag  gtctccaat  gcgagaagg  catcatggc  900
gagatctac  aaaacggcc  cgtggaggg  gctttctct  tgtattcgg  cttcctgct  960
tacaagtca  gagtgtacc  acacgtcac  ggagagatg  tgggtggcc  tgccatccg  1020
atcctgggc  ggggagtgg  gaatggcac  ccctactgg  tggttgcca  ctcctggaa  1080
actgactgg  gtgacaatg  cttctttaa  atactcaga  gacaggatc  ctgtggaat  1140
gaatcagaa  tggtggctg  aattccacg  accgatcag  actgggaaa  gatctaatc  1200
gccgtgggc  tgtcgtgcc  gtcctgggg  cgagatcgg  gtagaaatg  attttattc  1260
ttaagttca  gtaagatac  agtttcagg  agggtctga  ggactggat  ggccaaaca  1320
cagacctgt  ttccaagga  accaagtcc  ggctacatc  cagcctgtg  ttacagtgc  1380
gacaggcca  gtgagccac  gctgccagc  cagagcgtc  ttccccctg  agactagtg  1440
cgtgggagt  cctgctgcc  agctgctgt  gccccctcc  tgatccatc  atctccagg  1500
agcaagaca  agacgcagg  tggaaagcg  agttcctaa  aggatgaaa  ttcccccat  1560
agttccccc  gtacctcca  gcaagtagc  ttccacatt  gtcacagaa  tcagaggag  1620
gatggtgtt  ggagccctt  ggagaacgc  agtctccag  tccccctgc  tctatcgag  1680
ttgcaatgt  acaacctct  tgatcttgt  ctcagcatg  ttctttaat  gaagtttta  1740
ttttcgtgc  ctctgctaa  catgtgggt  agccagtgg  acagcggga  cctgtgctg  1800
tttgcagat  gcctcctaa  gacgcggct  aaaaggaaa  caagtggtc  ggagttgtt  1860
ctgacccac  gatctctac  accacaagg  aaatagttt  ggagaaacc  gcttttact  1920
tttttgaaa  attacagct  caccctgtc  agttaacaa  gaatgcctg  gccaataaa  1980
ggtttctcc  acttga  1996



<210> 7561
<211> 339
<212> PRT
<213> Homo sapiens
<308> P07858
<400> 7561

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
  1               5                  10                  15
Ala Arg Ser Arg Pro Ser Phe His Pro Val Ser Asp Glu Leu Val Asn 
             20                  25                  30
Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
         35                  40                  45
Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
     50                  55                  60
Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
 65                  70                  75                  80
Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                 85                  90                  95
Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
             100                105                110
Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
         115                120                125
Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
     130                135                140
Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
 145                150                155                160
Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                 165                170                175
Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
             180                185                190
Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
         195                200                205
Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
     210                215                220
Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
 225                230                235                240
Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                 245                250                255
Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
             260                265                270
Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
         275                280                285
Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
     290                295                300
Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
 305                310                315                320
Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                 325                330                335
Glu Lys Ile 
             340



<210> 7562
<211> 422
<212> DNA
<213> Rattus norvegicus
<308> H33426
<400> 7562

aaagattta  tcatgcagt  tatgtatat  agtnctgtc  tcatacaca  cagaaggaa  60
cagacctca  agatggttg  nagccacta  ggggttgtt  ggaattgaa  ttaggacct  120
tggaagaac  actgggtgc  atcactcag  cccaggttt  tgggagaga  agtgtcctg  180
gtagcctat  actgattag  aatttgaat  tcttctgcc  ccacctacc  catgctggg  240
tgactgcta  gagttgtag  ttccagaaa  gatgaacat  aagaccttt  tgcttctgt  300
acagaagtt  aagaaccat  ggaacatta  tttggtttc  acaggatgg  gtttgttca  360
ggctgagag  ctcaagtga  caatttagc  gagtctgta  acaaacaga  ttaccactg  420
gg  422



<210> 7563
<211> 339
<212> PRT
<213> Rattus norvegicus
<308> NP_031824
<400> 7563

Met Trp Trp Ser Leu Ile Leu Leu Ser Cys Leu Leu Ala Leu Thr Ser 
  1               5                  10                  15
Ala His Asp Lys Pro Ser Phe His Pro Leu Ser Asp Asp Leu Ile Asn 
             20                  25                  30
Tyr Ile Asn Lys Gln Asn Thr Thr Trp Gln Ala Gly Arg Asn Phe Tyr 
         35                  40                  45
Asn Val Asp Ile Ser Tyr Leu Lys Lys Leu Cys Gly Thr Val Leu Gly 
     50                  55                  60
Gly Pro Lys Leu Pro Gly Arg Val Ala Phe Gly Glu Asp Ile Asp Leu 
 65                  70                  75                  80
Pro Glu Thr Phe Asp Ala Arg Glu Gln Trp Ser Asn Cys Pro Thr Ile 
                 85                  90                  95
Gly Gln Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
             100                105                110
Ala Val Glu Ala Ile Ser Asp Arg Thr Cys Ile His Thr Asn Gly Arg 
         115                120                125
Val Asn Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ile 
     130                135                140
Gln Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ser Gly Ala Trp Ser 
 145                150                155                160
Phe Trp Thr Lys Lys Gly Leu Val Ser Gly Gly Val Tyr Asn Ser His 
                 165                170                175
Val Gly Cys Leu Pro Tyr Thr Ile Pro Pro Cys Glu His His Val Asn 
             180                185                190
Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Arg Cys Asn 
         195                200                205
Lys Ser Cys Glu Ala Gly Tyr Ser Pro Ser Tyr Lys Glu Asp Lys His 
     210                215                220
Phe Gly Tyr Thr Ser Tyr Ser Val Ser Asn Ser Val Lys Glu Ile Met 
 225                230                235                240
Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Thr Val Phe 
                 245                250                255
Ser Asp Phe Leu Thr Tyr Lys Ser Gly Val Tyr Lys His Glu Ala Gly 
             260                265                270
Asp Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
         275                280                285
Asn Gly Val Pro Tyr Trp Leu Ala Ala Asn Ser Trp Asn Leu Asp Trp 
     290                295                300
Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Glu Asn His Cys Gly 
 305                310                315                320
Ile Glu Ser Glu Ile Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                 325                330                335
Gly Arg Phe 
             340



<210> 7564
<211> 1996
<212> DNA
<213> Homo sapiens
<308> NM_001908
<400> 7564

tccggcaac  ccaaccgct  cgctgcgcg  aggctgggc  gcaggctct  ggctgcagc  60
ctgggctgg  gtgcagtgg  gcgaccacg  ctcacggca  cctcagcca  ccagatgta  120
gcgatctgg  tcccacctc  gcctcccga  tagtggatc  aggatccgg  ttccaacat  180
tggcagctc  gggcctccc  ctgctgcct  ctggtgttg  ccaatgccc  gagcaggcc  240
tctttccat  ccctgtcgg  tgagctggt  aactatgtc  acaaacgga  taccacgtg  300
caggccggg  acaacttct  caacgtgga  atgagctac  tgaagaggc  atgtggtac  360
ttcctgggt  ggcccaagc  accccagag  gttatgttt  ccgaggacc  gaagctgcc  420
gcaagcttc  atgcacggg  acaatggcc  cagtgtccc  ccatcaaag  gatcagaga  480
cagggctcc  gtggctcct  ctgggcctt  ggggctgtg  aagccatct  tgaccggat  540
tgcatccac  ccaatgcgc  cgtcagcgt  gaggtgtcg  cggaggacc  gctcacatg  600
tgtggcagc  tgtgtgggg  cggctgtaa  ggtggctat  ctgctgaag  ttggaactt  660
tggacaaga  aaggcctgg  ttctggtgg  ctctatgaa  cccatgtag  gtgcagacc  720
tactccatc  ctccctgtg  gcaccacgt  aacggctcc  ggcccccat  cacggggga  780
ggagatacc  ccaagtgta  caagatctg  gagcctggc  acagcccga  ctacaaaca  840
gacaagcac  acggataca  ttcctacag  gtctccaat  gcgagaagg  catcatggc  900
gagatctac  aaaacggcc  cgtggaggg  gctttctct  tgtattcgg  cttcctgct  960
tacaagtca  gagtgtacc  acacgtcac  ggagagatg  tgggtggcc  tgccatccg  1020
atcctgggc  ggggagtgg  gaatggcac  ccctactgg  tggttgcca  ctcctggaa  1080
actgactgg  gtgacaatg  cttctttaa  atactcaga  gacaggatc  ctgtggaat  1140
gaatcagaa  tggtggctg  aattccacg  accgatcag  actgggaaa  gatctaatc  1200
gccgtgggc  tgtcgtgcc  gtcctgggg  cgagatcgg  gtagaaatg  attttattc  1260
ttaagttca  gtaagatac  agtttcagg  agggtctga  ggactggat  ggccaaaca  1320
cagacctgt  ttccaagga  accaagtcc  ggctacatc  cagcctgtg  ttacagtgc  1380
gacaggcca  gtgagccac  gctgccagc  cagagcgtc  ttccccctg  agactagtg  1440
cgtgggagt  cctgctgcc  agctgctgt  gccccctcc  tgatccatc  atctccagg  1500
agcaagaca  agacgcagg  tggaaagcg  agttcctaa  aggatgaaa  ttcccccat  1560
agttccccc  gtacctcca  gcaagtagc  ttccacatt  gtcacagaa  tcagaggag  1620
gatggtgtt  ggagccctt  ggagaacgc  agtctccag  tccccctgc  tctatcgag  1680
ttgcaatgt  acaacctct  tgatcttgt  ctcagcatg  ttctttaat  gaagtttta  1740
ttttcgtgc  ctctgctaa  catgtgggt  agccagtgg  acagcggga  cctgtgctg  1800
tttgcagat  gcctcctaa  gacgcggct  aaaaggaaa  caagtggtc  ggagttgtt  1860
ctgacccac  gatctctac  accacaagg  aaatagttt  ggagaaacc  gcttttact  1920
tttttgaaa  attacagct  caccctgtc  agttaacaa  gaatgcctg  gccaataaa  1980
ggtttctcc  acttga  1996



<210> 7565
<211> 339
<212> PRT
<213> Homo sapiens
<308> P07858
<400> 7565

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
  1               5                  10                  15
Ala Arg Ser Arg Pro Ser Phe His Pro Val Ser Asp Glu Leu Val Asn 
             20                  25                  30
Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
         35                  40                  45
Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
     50                  55                  60
Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
 65                  70                  75                  80
Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                 85                  90                  95
Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
             100                105                110
Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
         115                120                125
Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
     130                135                140
Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
 145                150                155                160
Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                 165                170                175
Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
             180                185                190
Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
         195                200                205
Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
     210                215                220
Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
 225                230                235                240
Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                 245                250                255
Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
             260                265                270
Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
         275                280                285
Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
     290                295                300
Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
 305                310                315                320
Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                 325                330                335
Glu Lys Ile 
             340



<210> 7566
<211> 419
<212> DNA
<213> Rattus norvegicus
<308> H33459
<400> 7566

gaacatgtt  ccttttatt  aaaagtgtt  ctagccctg  ctggggctc  tatacaaaa  60
caacacaca  cccaaatna  gctgnttcc  gtctctaga  tcggggaca  tgttggggt  120
tagcgagtg  aatgtgtgc  gaaggaggg  acccaggng  ctcctaccc  agtcctcag  180
atggcacca  ctgtcccgt  gcctttcta  ttaccacag  ggaaggaaa  gcagtnttt  240
gagatgctc  gtagaagtc  agcatggat  gcttcatca  caggctggg  cagtnttgg  300
aagacgcct  attcgcctt  tgttcctgt  ttgatcccg  ntcttcttc  ccatctcag  360
atccgtcan  gtctccagc  gggggcacc  ctggtcagc  tctccagta  ttcggatgg  419



<210> 7567
<211> 419
<212> DNA
<213> Rattus norvegicus
<308> H33459
<400> 7567

gaacatgtt  ccttttatt  aaaagtgtt  ctagccctg  ctggggctc  tatacaaaa  60
caacacaca  cccaaatna  gctgnttcc  gtctctaga  tcggggaca  tgttggggt  120
tagcgagtg  aatgtgtgc  gaaggaggg  acccaggng  ctcctaccc  agtcctcag  180
atggcacca  ctgtcccgt  gcctttcta  ttaccacag  ggaaggaaa  gcagtnttt  240
gagatgctc  gtagaagtc  agcatggat  gcttcatca  caggctggg  cagtnttgg  300
aagacgcct  attcgcctt  tgttcctgt  ttgatcccg  ntcttcttc  ccatctcag  360
atccgtcan  gtctccagc  gggggcacc  ctggtcagc  tctccagta  ttcggatgg  419



<210> 7568
<211> 551
<212> DNA
<213> Rattus norvegicus
<308> H33461
<400> 7568

gcattacat  aagctctga  atttaattg  tgaattgtt  ccacatggc  tattgttgg  60
ttcctacaa  aaagaatac  agtnctagt  tatnctatc  ttncatttt  gaggccact  120
gacagtaag  ttgcacatt  gccaagtct  ctgagttac  gtattgtct  cgatagtca  180
tgccctccg  taagagcag  tgctaatgg  aactaataa  atataccac  tagaaaaaa  240
cacgttttt  tttcaaaac  atttgcttc  ttttgagca  aaaacaaaa  aaaactaaa  300
tgtattggg  gagttggta  gcaacgagg  taaaacaag  gaactgtaa  acagtgtat  360
tggcacaat  ttgaagaaa  atgcaagtt  tagttttgt  cttatggta  tgccctatt  420
agctacaaa  atgtaaata  tattacttn  cttaatata  taaatccca  aggntcatn  480
aattcccct  ctcctctgg  aatttngta  cnctatctg  aaatccagt  gtggaaaca  540
gcggcccaa  c  551



<210> 7569
<211> 216
<212> PRT
<213> Rattus norvegicus
<308> AAK29401
<400> 7569

Met Ser Arg Leu Trp Tyr Gly Lys Lys Gly Arg Arg His Gln Gln Val 
  1               5                  10                  15
Asn His Lys Tyr Thr Leu Ile Thr Thr Arg Glu Asp Ile Asn Ser Lys 
             20                  25                  30
Gln Ala Ala Pro Ala Lys Ala Asp Leu Glu Pro Glu Ser Phe Arg Pro 
         35                  40                  45
Asn Leu Ser Asp Pro Ser Glu Leu Leu Leu Pro Asp Gln Ile Glu Lys 
     50                  55                  60
Leu Thr Lys His Leu Pro Pro Arg Thr Ile Gly Tyr Pro Trp Thr Leu 
 65                  70                  75                  80
Val Tyr Gly Thr Gly Lys His Gly Thr Ser Leu Lys Thr Leu Tyr Arg 
                 85                  90                  95
Thr Met Thr Gly Leu Asp Thr Pro Val Leu Met Val Ile Lys Asp Ser 
             100                105                110
Asp Gly Gln Val Phe Gly Ala Leu Ala Ser Glu Pro Phe Lys Val Ser 
         115                120                125
Asp Gly Phe Tyr Gly Thr Gly Glu Thr Phe Val Phe Thr Phe Cys Pro 
     130                135                140
Glu Phe Glu Val Phe Lys Trp Thr Gly Asp Asn Met Phe Phe Ile Lys 
 145                150                155                160
Gly Asp Met Asp Ser Leu Ala Phe Gly Gly Gly Gly Gly Glu Phe Ala 
                 165                170                175
Leu Trp Leu Asp Gly Asp Leu Tyr His Gly Arg Ser His Ser Cys Lys 
             180                185                190
Thr Phe Gly Asn His Thr Leu Ser Lys Lys Glu Asp Phe Phe Ile Gln 
         195                200                205
Asp Ile Glu Ile Trp Ala Phe Glu 
     210                215



<210> 7570
<211> 779
<212> DNA
<213> Homo sapiens
<308> BG718301
<400> 7570

agcgggcct  ttgggaggc  cgcggagcc  cctcccctg  gtcaggtct  atgggccgg  60
gggcgcgct  gtggtggcc  ccaccgccg  aaccgtcga  ctcctgggc  ccagttccg  120
gtccagccc  gcggcagca  ggactacct  acgacgttc  ccgagaaga  tgggcgcct  180
ctgcggggc  cggccaacc  cctgttggg  ttcgggggc  gcggcgaag  ccggcagac  240
ctggccaaa  gaagaccct  gacaagaaa  atggaagac  aatgtcttt  cagaaacct  300
aagggacta  tgagtatac  gttgaatca  gggattctt  gaatagcat  gccctgaag  360
ttgatacaa  acctaacga  cttgttcaa  taaataagt  attctcccg  gcagttgtt  420
ctggacagg  tctgtatgt  cctgatcct  aatatgtct  cagtgttga  agctctcca  480
ctctaagcc  cgtaagtcc  ctgtcacca  catcatctg  ggctgaatt  gataagacc  540
ctaatcctg  tgtccatcc  acagaagca  ctccctcat  tactttcac  ggtattcga  600
ctgcacgag  tgtatcttc  acttctgag  aggaggaag  atttactga  aaatttctt  660
aaattaatt  caaatatat  accagtggc  agggcacag  cagtggtgt  ctgctagtt  720
caccaaaat  atataagtg  ttgatccac  taaaaatga  cctttggtt  agagaatgg  779



<210> 7571
<211> 352
<212> DNA
<213> Rattus norvegicus
<308> H33467
<400> 7571

cacagtgaa  tgctttatt  ttaaattca  cccctccac  gtggacaac  tgacagttg  60
acatgatga  actcatcag  caaaggtct  tcagttagg  aagaagtcc  ctccacaag  120
ctgcttgaa  gtgaacact  gagagtgag  tgagatcct  acaacagat  cacaatatc  180
gacgaaacc  cacacactt  gaaatccta  tcactcctt  aatatgtaa  acaaaagca  240
aaaaatcac  tctagtgag  gatctgtcc  gtagtaatt  catcctcgt  gggcttgga  300
tccagggng  ccagagcgc  cccttcaga  gaattgtgc  tcactttca  cg  352



<210> 7572
<211> 569
<212> DNA
<213> Rattus norvegicus
<308> H33491
<400> 7572

ttcctggtt  tggacaggg  cttcccatc  tctcttcca  cctttctct  tggtccctg  60
cagtagctc  gcatgtncc  taccttttc  nactctggc  ctttgagtg  ggcaaatcc  120
atagctctg  ccctccaaa  ctgttcgag  agaaggagg  agaggagga  gaggattcg  180
gtcttctgg  aagcgggga  agcgcctcc  cagacaggt  tcagctcac  ctccgtctc  240
ttagttatg  ttgctctta  ttttcatga  tttgttgtc  agcatgctc  gagcgtttg  300
nagatgctt  atggcatca  acacaagga  gcccggtat  accaaccat  tggcattca  360
gataacgaa  taggaacca  aaataaagg  ggtgaccta  ctctccatg  tggaatcca  420
cgcggagtt  ggtcaggaa  tacagcaca  ccccatata  ctggcccac  gacaccaca  480
gctgtagga  aaagcggaa  ggtttgatg  cggagaaag  cgatcacca  ccataggct  540
agtgggtcc  cagagacaa  ctgtgacaa  569



<210> 7573
<211> 230
<212> PRT
<213> Rattus norvegicus
<308> Q9JJ46
<400> 7573

Met Thr Thr Asn Met Leu Pro Leu His Pro Tyr Trp Pro Arg His Leu 
  1               5                  10                  15
Arg Leu Asp Asn Phe Val Pro Asn Asp Leu Pro Thr Trp His Ile Leu 
             20                  25                  30
Val Gly Leu Phe Ser Phe Ser Gly Val Leu Ile Val Ile Thr Trp Leu 
         35                  40                  45
Leu Ser Ser Arg Val Ser Val Val Pro Leu Gly Thr Gly Arg Arg Leu 
     50                  55                  60
Ala Leu Cys Trp Phe Ala Val Cys Thr Phe Ile His Leu Val Ile Glu 
 65                  70                  75                  80
Gly Trp Phe Ser Phe Tyr His Glu Ile Leu Leu Glu Asp Gln Ala Phe 
                 85                  90                  95
Leu Ser Gln Leu Trp Lys Glu Tyr Ser Lys Gly Asp Ser Arg Tyr Ile 
             100                105                110
Leu Ser Asp Gly Phe Ile Val Cys Met Glu Ser Val Thr Ala Cys Leu 
         115                120                125
Trp Gly Pro Leu Ser Leu Trp Val Val Ile Ala Phe Leu Arg His Gln 
     130                135                140
Pro Phe Arg Phe Val Leu Gln Leu Val Val Ser Val Gly Gln Ile Tyr 
 145                150                155                160
Gly Asp Val Leu Tyr Phe Leu Thr Glu Leu Arg Asp Gly Phe Gln His 
                 165                170                175
Gly Glu Leu Gly His Pro Leu Tyr Phe Trp Phe Tyr Phe Val Ile Met 
             180                185                190
Asn Ala Ile Trp Leu Val Ile Pro Gly Ile Leu Val Phe Asp Ala Ile 
         195                200                205
Lys His Leu Thr Asn Ala Gln Ser Met Leu Asp Asn Lys Val Met Lys 
     210                215                220
Ile Lys Ser Lys His Asn 
 225                230



<210> 7574
<211> 1073
<212> DNA
<213> Homo sapiens
<308> Z37986
<400> 7574

cggagccag  gtgggaggc  gctgccgtc  cgcgccttg  tttttctgt  ccttttttt  60
ttttttttt  aacttcctg  ctatcacac  cagccatca  cccacaaag  catgactac  120
aacgcgggc  ccttgcacc  atactggcc  cagcaccta  gactggaca  ctttgtacc  180
aatgaccgc  ccacctggc  tatactggc  ggcctcttc  ctgtcacag  ggtcttagt  240
gtgaccaca  ggctgttgt  aggtcgtgc  gcggttgtc  cattgggga  ttggcggcg  300
ctgtccctg  gctggtttg  agtgtgtgg  ttcattcac  tggtgatcg  gggctggtt  360
gttctctac  acgaagacc  gcttggaga  caagccttc  tatctcaac  ctggaaaga  420
tatgccaag  gagacagcc  atacatcct  ggtgacaac  tcacagtgt  catggaaac  480
atcacagct  gcctgtggg  accactcag  ctgtgggtg  tgatcgcct  tctccgcca  540
catcccctc  gcttcattc  acagcttgt  gtctctgtg  gccagatct  tggggatgt  600
ctctacttc  tgacagagc  ccgcgacgg  ttccagcac  gagagctgg  ccaccctct  660
tacttctgg  tttactttg  cttcatgaa  gccctgtgg  tggtgctgc  tggagtcct  720
gtgcttgat  ctgtgaagc  cctcactca  gcccagagc  cgctggatg  caaggccac  780
aaagccaag  gcaagaaga  ctgaggagt  gtggaccag  ctcgaacac  ggccgagga  840
gagctctct  cctgccaga  gagtctagt  ctgctccca  agtttggag  gacaaagct  900
attgatctg  cacactcag  ctcatgggc  ggcacaaga  ggggaataa  ggggctgtg  960
gaaggcact  ctgggagcc  ttagaacac  gatacaaga  aagccagga  gtctatgat  1020
gtgacgatt  ttaaaatca  gaaataaaa  atcttgact  taaaaaaaa  aaa  1073



<210> 7575
<211> 230
<212> PRT
<213> Homo sapiens
<308> Q15125
<400> 7575

Met Thr Thr Asn Ala Gly Pro Leu His Pro Tyr Trp Pro Gln His Leu 
  1               5                  10                  15
Arg Leu Asp Asn Phe Val Pro Asn Asp Arg Pro Thr Trp His Ile Leu 
             20                  25                  30
Ala Gly Leu Phe Ser Val Thr Gly Val Leu Val Val Thr Thr Trp Leu 
         35                  40                  45
Leu Ser Gly Arg Ala Ala Val Val Pro Leu Gly Thr Trp Arg Arg Leu 
     50                  55                  60
Ser Leu Cys Trp Phe Ala Val Cys Gly Phe Ile His Leu Val Ile Glu 
 65                  70                  75                  80
Gly Trp Phe Val Leu Tyr Tyr Glu Asp Leu Leu Gly Asp Gln Ala Phe 
                 85                  90                  95
Leu Ser Gln Leu Trp Lys Glu Tyr Ala Lys Gly Asp Ser Arg Tyr Ile 
             100                105                110
Leu Gly Asp Asn Phe Thr Val Cys Met Glu Thr Ile Thr Ala Cys Leu 
         115                120                125
Trp Gly Pro Leu Ser Leu Trp Val Val Ile Ala Phe Leu Arg Gln His 
     130                135                140
Pro Leu Arg Phe Ile Leu Gln Leu Val Val Ser Val Gly Gln Ile Tyr 
 145                150                155                160
Gly Asp Val Leu Tyr Phe Leu Thr Glu His Arg Asp Gly Phe Gln His 
                 165                170                175
Gly Glu Leu Gly His Pro Leu Tyr Phe Trp Phe Tyr Phe Val Phe Met 
             180                185                190
Asn Ala Leu Trp Leu Val Leu Pro Gly Val Leu Val Leu Asp Ala Val 
         195                200                205
Lys His Leu Thr His Ala Gln Ser Thr Leu Asp Ala Lys Ala Thr Lys 
     210                215                220
Ala Lys Ser Lys Lys Asn 
 225                230



<210> 7576
<211> 224
<212> DNA
<213> Rattus norvegicus
<308> H33614
<400> 7576

agtgcaaac  tggctattt  tttctnaga  tctggaggc  tcagggagc  tcctctggg  60
ccttagtac  gacacttgt  gtggctagc  tctgtaatt  cagaaggat  tctgatggt  120
cgtggtcat  tctgtgttc  tcctgcttc  tcttaacct  ttggggaca  tagccagtt  180
taatggatt  attgcaact  cattttatt  ttttngctt  atac  224



<210> 7577
<211> 411
<212> DNA
<213> Rattus norvegicus
<308> H33636
<400> 7577

cactgcatt  tctttattg  atccggagc  agttggcca  accattcca  atttggaga  60
ggtttaaaa  aaaagccca  caatcttct  atcttacct  ccccccccc  accccttcc  120
cacaactgc  cagcaatgt  tgaacacat  tggtgacaa  aacaatttg  aaaagtggt  180
tagaaatta  attatgaat  gttccaaca  aagacacag  tggcttcct  ctgagtcag  240
tatttttac  taaactaca  ggatttttt  tattacatc  aagacaaca  antagattc  300
tcacaagaa  caacaggag  accaaggtt  catgcgagg  tttgtaagg  aacaagggt  360
gttgtcaca  atggctaga  ctaagtcaa  agtgagcag  tggcagcaa  g  411



<210> 7578
<211> 461
<212> PRT
<213> Rattus norvegicus
<308> AAB34938
<400> 7578

Met Tyr Asn Thr Val Trp Ser Met Asp Arg Asp Asp Ala Asp Trp Arg 
  1               5                  10                  15
Glu Val Met Met Pro Tyr Ser Thr Glu Leu Ile Phe Tyr Ile Glu Met 
             20                  25                  30
Asp Pro Pro Ala Leu Pro Pro Lys Pro Pro Lys Pro Met Thr Pro Ala 
         35                  40                  45
Val Thr Asn Gly Met Lys Asp Ser Phe Ile Ser Leu Gln Asp Ala Glu 
     50                  55                  60
Trp Tyr Trp Gly Asp Ile Ser Arg Glu Glu Val Asn Asp Lys Leu Arg 
 65                  70                  75                  80
Asp Met Pro Asp Gly Thr Phe Leu Val Arg Asp Ala Ser Thr Lys Met 
                 85                  90                  95
Gln Gly Asp Tyr Thr Leu Thr Leu Arg Lys Gly Gly Asn Asn Lys Leu 
             100                105                110
Ile Lys Ile Tyr His Arg Asp Gly Lys Tyr Gly Phe Ser Glu Pro Leu 
         115                120                125
Thr Phe Thr Ser Val Val Glu Leu Ile Asn His Tyr His His Glu Ser 
     130                135                140
Leu Ala Gln Tyr Asn Pro Lys Leu Asp Val Lys Leu Thr Tyr Pro Val 
 145                150                155                160
Ser Arg Phe Gln Gln Asp Gln Leu Val Lys Glu Asp Asn Ile Asp Ala 
                 165                170                175
Val Gly Lys Asn Leu Gln Glu Phe His Ser Gln Tyr Gln Glu Lys Ser 
             180                185                190
Lys Glu Tyr Asp Arg Leu Tyr Glu Glu Tyr Thr Arg Thr Ser Gln Glu 
         195                200                205
Ile Gln Met Lys Arg Thr Ala Ile Glu Ala Phe Asn Glu Thr Ile Lys 
     210                215                220
Ile Phe Glu Glu Gln Cys His Thr Gln Glu Gln His Ser Lys Asp Tyr 
 225                230                235                240
Ile Glu Arg Phe Arg Arg Glu Gly Asn Glu Lys Glu Ile Glu Arg Ile 
                 245                250                255
Met Met Asn Tyr Asp Lys Leu Lys Ser Arg Leu Gly Glu Ile His Asp 
             260                265                270
Ser Lys Leu Arg Leu Glu Gln Asp Leu Lys Lys Gln Ala Leu Asp Asn 
         275                280                285
Arg Glu Ile Asp Lys Lys Met Asn Ser Ile Lys Pro Asp Leu Ile Gln 
     290                295                300
Leu Arg Lys Ile Arg Asp Gln His Leu Val Trp Leu Asn His Arg Gly 
 305                310                315                320
Val Arg Gln Arg Arg Leu Asn Ala Trp Leu Gly Ile Lys Asn Glu Asp 
                 325                330                335
Ser Asp Glu Ser Tyr Phe Ile Asn Glu Glu Asp Glu Asn Leu Pro His 
             340                345                350
Tyr Asp Glu Lys Thr Trp Phe Val Glu Asp Ile Asn Arg Val Gln Ala 
         355                360                365
Glu Asp Leu Leu Tyr Gly Lys Pro Asp Gly Ala Phe Leu Ile Arg Glu 
     370                375                380
Ser Ser Lys Lys Gly Cys Tyr Ala Cys Ser Val Val Ala Asp Gly Glu 
 385                390                395                400
Val Lys His Cys Val Ile Tyr Ser Thr Ala Arg Gly Tyr Gly Phe Ala 
                 405                410                415
Glu Pro Tyr Asn Leu Tyr Ser Ser Leu Lys Glu Leu Val Leu His Tyr 
             420                425                430
Gln Gln Thr Ser Leu Val Gln His Asn Asp Ser Leu Asn Val Arg Leu 
         435                440                445
Ala Tyr Pro Val His Ala Gln Met Pro Thr Leu Cys Arg 
     450                455                460



<210> 7579
<211> 3371
<212> DNA
<213> Homo sapiens
<308> NM_003629
<400> 7579

tttctccca  cgtgttctt  tttttcctc  tcattctcc  tccttcgag  acacaaaag  60
ggcttccgc  gaaagattt  gaggcggtg  gagcttttc  ccccggaga  cgactgtgt  120
gaaaggatt  ttgggaagc  gctttttaa  acctctgct  tccgtcccc  aagcctctg  180
gtaatcctc  gaggagaaa  gcccatagc  tgaaagttc  ggggcattt  gttgtgttc  240
gtaggagag  gggggagga  cctgttcgg  tagtttggc  ggactggta  tggccgttg  300
aaaacccga  gtacatttc  gtgtggaac  tttgcagat  tatattttt  gatttttaa  360
taccagata  aaaatatat  ccttctata  atctcctgg  gacctgccc  tgacagcgc  420
atgtacaat  cggtgtgga  tatggaccg  gatgacgca  actggaggg  ggtgatgat  480
ccctattcg  cagaactga  attttatat  gaaatggat  ctccagctc  tccaccaaa  540
ccacctaag  caatgactt  agcagttcc  aatggaatg  aggacagtt  tgtttctct  600
caggatgca  aatggtact  gggggatat  tcaagggag  aggtaaatg  caaattgcg  660
gatatgcca  atgggacct  cttggtccg  gatgcctca  caaaaatgc  gggagatta  720
actttgact  tgcggaagg  aggcaataa  aagttaata  agatctatc  ccgggatgg  780
aaatatggc  tttctgatc  tctgacatt  aattccgtg  tggagctca  taaccacta  840
caccatgaa  ctcttgctc  gtacaatcc  aaacttgat  tgaagctga  gtacccagt  900
tccagatac  aacaggatc  gttggtaaa  gaagataat  ttgatgcag  aggtaaaaa  960
ctgcaagaa  accactctc  gtatcagga  aagagtaaa  agtatgata  gctgtatga  1020
gaatatact  gaacatccc  ggaaataca  atgaagagg  ctgcaatag  agcttttaa  1080
gaaacaatt  aaatatttg  agagcagtg  cacacacaa  aacaacata  caaagaata  1140
attgagcga  ttcgcagag  ggggaatga  aaggagatt  aacgaatta  gatgaatta  1200
gataaattg  aatcacgtc  gggtgagat  catgatagc  aaatgcgtc  agagcagga  1260
ttgaagaaa  aagctttgg  caaccgaga  atagataaa  aaatgaata  tatcaaacc  1320
gacctgatc  agctgcgaa  gatccgaga  caacacctt  tatggctca  tcacaaagg  1380
gtgagacag  aacgcctga  tgtctggct  ggaattaag  atgaggatg  tgatgagaa  1440
tattttatc  atgaggaag  tgaaaacct  ccccattat  atgagaaaa  ctggtttgt  1500
gaggatatc  atcgagtac  agcagagga  ttgctttat  ggaaacctg  tggtgcatt  1560
ttaattcgt  agagtagca  gaaaggatg  tatgcttgc  ctgtggtgg  cgatgggga  1620
gtgaagcac  gtgtgatct  cagcactgc  cggggctat  gctttgcag  gccctacaa  1680
ctgtacagc  ctctgaagg  gctagtgct  cattaccag  agacatcct  ggttcagca  1740
aacgactcc  tcaacgtca  gcttgccta  cctgttcat  cacagatgc  ctcgctttg  1800
agataaaga  gaagtggga  gagaggtgg  cttctggca  ttttttcta  agtttttat  1860
agactacga  gagggcatt  tttctacat  gactgcttg  tttgcacaa  aagtgattt  1920
gtgaatgtg  agtggagag  ccgaggagc  gccggccgg  atgggggca  tagaggcct  1980
aggttctct  ggactcagc  atgccgctg  actgacata  taagctgga  gcagatgtt  2040
tttttgaaa  tctgtttca  tggggtttt  gttttgttt  gccagacac  ctcaacaga  2100
tattaggct  gatggttat  gcgggtggg  ttgtatttg  aagcctctg  agagaccat  2160
tctttttaa  atctaactc  tgagagtgc  gcaggggca  ggctctgct  ggagttgtg  2220
tttgctttg  cagtctctc  tccccccac  aagaaggct  tttaggttt  gtgatagaa  2280
gggatttga  gaaaaagac  accaaagga  aatggggag  cttgggatt  catttaaat  2340
atctaagcc  agatgataa  aaaaacctt  aactgaagg  actttgttt  ttacaacat  2400
atttaggct  cagcatctc  ccagcccct  cctctgaag  agtattatg  tcagaagcc  2460
acaaaacag  ttgttgcca  accaatgtt  gatgggaaa  cgtggcact  atagttgaa  2520
gtatacttc  gtaccaaaa  ttgaacata  aagactaga  tttgtgagt  ttagcaaac  2580
ctaaattga  cactgtaac  aaccccttc  gtccttcct  cctgtttct  tgagatgag  2640
aatagcatt  tttttgtgg  gatggtgag  tttgaatca  aaaatgaag  tggtgcttg  2700
atggtgttt  cttagccta  agaatgatc  gttgtttga  acctttgta  cttgtttgt  2760
tgagtaaag  aaaggtgca  tgcagtgct  ttagatggc  tgatatacc  aataacaat  2820
tagacaaca  tattatatg  gcttcccca  gtttaaagg  cctgcagaa  tagtaaaca  2880
ggtttaatt  cccttcatt  ccccctcct  tgctggatg  ggttttggg  gctataggt  2940
gctaaggag  ggagtcaga  tgtggtcag  tgcctcagt  aatcacaga  ccaggggcc  3000
tgtggtcca  ggtgagagt  acaccacat  acacatgtg  ttccataca  tggtttctg  3060
agcttttgc  gggagagaa  atggcttag  gtttagact  ttagtagaa  ccatctgga  3120
gcttttctc  ttgcctttt  ttgtgatcc  gccattaag  ctatgtgca  tctgccctc  3180
tgctccagt  gccttgatt  taggccagg  atcttctgc  ccatgtggc  taagccttc  3240
agctgagtg  agctaggca  atggagtgg  ggcaggcat  tattcctgc  cccatcatg  3300
cccacaccc  tcagtcaac  ctcatttga  aaatagagt  cagctgcct  tgagccaat  3360
ctgggacct  a  3371



<210> 7580
<211> 461
<212> PRT
<213> Homo sapiens
<308> Q92569
<400> 7580

Met Tyr Asn Thr Val Trp Ser Met Asp Arg Asp Asp Ala Asp Trp Arg 
  1               5                  10                  15
Glu Val Met Met Pro Tyr Ser Thr Glu Leu Ile Phe Tyr Ile Glu Met 
             20                  25                  30
Asp Pro Pro Ala Leu Pro Pro Lys Pro Pro Lys Pro Met Thr Ser Ala 
         35                  40                  45
Val Pro Asn Gly Met Lys Asp Ser Ser Val Ser Leu Gln Asp Ala Glu 
     50                  55                  60
Trp Tyr Trp Gly Asp Ile Ser Arg Glu Glu Val Asn Asp Lys Leu Arg 
 65                  70                  75                  80
Asp Met Pro Asp Gly Thr Phe Leu Val Arg Asp Ala Ser Thr Lys Met 
                 85                  90                  95
Gln Gly Asp Tyr Thr Leu Thr Leu Arg Lys Gly Gly Asn Asn Lys Leu 
             100                105                110
Ile Lys Ile Tyr His Arg Asp Gly Lys Tyr Gly Phe Ser Asp Pro Leu 
         115                120                125
Thr Phe Asn Ser Val Val Glu Leu Ile Asn His Tyr His His Glu Ser 
     130                135                140
Leu Ala Gln Tyr Asn Pro Lys Leu Asp Val Lys Leu Met Tyr Pro Val 
 145                150                155                160
Ser Arg Tyr Gln Gln Asp Gln Leu Val Lys Glu Asp Asn Ile Asp Ala 
                 165                170                175
Val Gly Lys Lys Leu Gln Glu Tyr His Ser Gln Tyr Gln Glu Lys Ser 
             180                185                190
Lys Glu Tyr Asp Arg Leu Tyr Glu Glu Tyr Thr Arg Thr Ser Gln Glu 
         195                200                205
Ile Gln Met Lys Arg Thr Ala Ile Glu Ala Phe Asn Glu Thr Ile Lys 
     210                215                220
Ile Phe Glu Glu Gln Cys His Thr Gln Glu Gln His Ser Lys Glu Tyr 
 225                230                235                240
Ile Glu Arg Phe Arg Arg Glu Gly Asn Glu Lys Glu Ile Glu Arg Ile 
                 245                250                255
Met Met Asn Tyr Asp Lys Leu Lys Ser Arg Leu Gly Glu Ile His Asp 
             260                265                270
Ser Lys Met Arg Leu Glu Gln Asp Leu Lys Lys Gln Ala Leu Asp Asn 
         275                280                285
Arg Glu Ile Asp Lys Lys Met Asn Ser Ile Lys Pro Asp Leu Ile Gln 
     290                295                300
Leu Arg Lys Ile Arg Asp Gln His Leu Val Trp Leu Asn His Lys Gly 
 305                310                315                320
Val Arg Gln Lys Arg Leu Asn Val Trp Leu Gly Ile Lys Asn Glu Asp 
                 325                330                335
Ala Asp Glu Asn Tyr Phe Ile Asn Glu Glu Asp Glu Asn Leu Pro His 
             340                345                350
Tyr Asp Glu Lys Thr Trp Phe Val Glu Asp Ile Asn Arg Val Gln Ala 
         355                360                365
Glu Asp Leu Leu Tyr Gly Lys Pro Asp Gly Ala Phe Leu Ile Arg Glu 
     370                375                380
Ser Ser Lys Lys Gly Cys Tyr Ala Cys Ser Val Val Ala Asp Gly Glu 
 385                390                395                400
Val Lys His Cys Val Ile Tyr Ser Thr Ala Arg Gly Tyr Gly Phe Ala 
                 405                410                415
Glu Pro Tyr Asn Leu Tyr Ser Ser Leu Lys Glu Leu Val Leu His Tyr 
             420                425                430
Gln Gln Thr Ser Leu Val Gln His Asn Asp Ser Leu Asn Val Arg Leu 
         435                440                445
Ala Tyr Pro Val His Ala Gln Met Pro Ser Leu Cys Arg 
     450                455                460



<210> 7581
<211> 447
<212> DNA
<213> Rattus norvegicus
<308> H33651
<400> 7581

cttttcttt  tttcttatt  ttgtttctc  gtgtaatgg  cctggttgt  ctagaactt  60
atctgtaga  catgctggc  tcaaacaca  agagatctg  ctacctctg  ctccaaaga  120
tttattctg  ttaatggat  tctaatatt  tatggcaaa  ccagactta  aaaaaaata  180
agctgcaag  tgtggtagg  atcgtatgc  tgtncctgt  actctacca  tcaggaagc  240
caggcaaat  ttcaagttc  aggccagcc  gatctatat  atgggttcc  gacagtgag  300
gcctgtctc  aacaaaaaa  ataatagtg  tctactgca  gctagattc  agaaattca  360
tggtgaaga  catggatgt  gattcgtgt  atcaaagtt  ctaagataa  agagtttta  420
aataaacgg  caaatgatt  caagaac  447



<210> 7583
<211> 367
<212> PRT
<213> Rattus norvegicus
<308> AAA75174
<400> 7583

Met Tyr Pro Glu Ser Thr Thr Gly Ser Pro Ala Arg Leu Ser Leu Arg 
  1               5                  10                  15
Gln Thr Gly Ser Pro Gly Met Ile Tyr Ser Thr Arg Tyr Gly Ser Pro 
             20                  25                  30
Lys Arg Gln Leu Gln Phe Tyr Arg Asn Leu Gly Lys Ser Gly Leu Arg 
         35                  40                  45
Val Ser Cys Leu Gly Leu Gly Thr Trp Val Thr Phe Gly Gly Gln Ile 
     50                  55                  60
Thr Asp Glu Met Ala Glu His Leu Met Thr Leu Ala Tyr Asp Asn Gly 
 65                  70                  75                  80
Ile Asn Leu Phe Asp Thr Ala Glu Val Tyr Ala Ala Gly Lys Ala Glu 
                 85                  90                  95
Val Val Leu Gly Asn Ile Ile Lys Lys Lys Gly Trp Arg Arg Ser Ser 
             100                105                110
Leu Val Ile Thr Thr Lys Ile Phe Trp Gly Gly Lys Ala Glu Thr Glu 
         115                120                125
Arg Gly Leu Ser Arg Lys His Ile Ile Glu Gly Leu Lys Ala Ser Leu 
     130                135                140
Glu Arg Leu Gln Leu Glu Tyr Val Asp Val Val Phe Ala Asn Arg Pro 
 145                150                155                160
Asp Pro Asn Thr Pro Met Glu Glu Thr Val Arg Ala Met Thr His Val 
                 165                170                175
Ile Asn Gln Gly Met Ala Met Tyr Trp Gly Thr Ser Arg Trp Ser Ser 
             180                185                190
Met Glu Ile Met Glu Ala Tyr Ser Val Ala Arg Gln Phe Asn Leu Ile 
         195                200                205
Pro Pro Ile Cys Glu Gln Ala Glu Tyr His Met Phe Gln Arg Glu Lys 
     210                215                220
Val Glu Val Gln Leu Pro Glu Leu Phe His Lys Ile Gly Val Gly Ala 
 225                230                235                240
Met Thr Trp Ser Pro Leu Ala Cys Gly Ile Val Ser Gly Lys Tyr Asp 
                 245                250                255
Ser Gly Ile Pro Pro Tyr Ser Arg Ala Ser Leu Lys Gly Tyr Gln Trp 
             260                265                270
Leu Lys Asp Lys Ile Leu Ser Glu Glu Gly Arg Arg Gln Gln Ala Lys 
         275                280                285
Leu Lys Glu Leu Gln Ala Ile Ala Glu Arg Leu Gly Cys Thr Leu Pro 
     290                295                300
Gln Leu Ala Ile Ala Trp Cys Leu Arg Asn Glu Gly Val Ser Ser Val 
 305                310                315                320
Leu Leu Gly Ala Ser Asn Ala Glu Gln Leu Met Glu Asn Ile Gly Ala 
                 325                330                335
Ile Gln Val Leu Pro Lys Leu Ser Ser Ser Ile Val His Glu Ile Asp 
             340                345                350
Ser Ile Leu Gly Asn Lys Pro Tyr Ser Lys Lys Asp Tyr Arg Ser 
         355                360                365



<210> 7584
<211> 3019
<212> DNA
<213> Homo sapiens
<308> NM_003636
<400> 7584

caccgagca  gtctggata  gtgaggctg  ctccatgta  ccagaatca  cgacgggct  420
cccggctcg  ctctcgctg  ggcagacgg  ctcccccgg  atgatctac  gtactcggt  480
tgggagtcc  aaaagacag  tccagtttt  caggaacct  ggcaagtct  gcctgcggg  540
ctcctgcct  ggacttgga  catgggtga  cttcggagg  cagatcacc  atgagatgg  600
agagcagct  atgaccttg  cctatgata  tggcatcaa  ctcttcgat  cagcagaag  660
ctacgcagc  ggcaaggct  aagtggtac  gggaaacat  attaagaag  aaggatgga  720
gcggtccag  ctcgtcatc  ccaccaaga  cttctgggg  ggaaaggcg  agacggagc  780
gggcctgtc  aggaagcac  taatcgaag  tctgaaagc  tccctggag  gactgcagc  840
ggagtacgt  gatgtggtg  ttgccaacc  cccggaccc  aacaccccg  tggaagaga  900
cgtccgcgc  atgacccac  tcatcaacc  ggggatggc  atgtactgg  gcacgtcac  960
ctggagctc  atggagatc  tggaggcct  ctccgtggc  cggcagttc  acctgaccc  1020
gcccatctg  gagcaggct  agtaccaca  gttccagcg  gagaaagtg  aggtgcagc  1080
gccggagct  ttccacaag  taggagtgg  cgccatgac  tggtcccct  tggcctgtg  1140
cattgtttc  ggcaagtac  acagtggca  cccacccta  tcaagagcc  ccttgaagg  1200
ctaccagtg  ctgaaggac  agatcctca  tgaggaggg  cggcgccag  aagccaagc  1260
gaaggagct  caggccatc  ccgagcgcc  gggctgcac  ctgccccag  tggccatag  1320
ctggtgcct  aggaatgag  gagtcagct  cgtgctcct  ggggcctcc  atgcggacc  1380
gctcatgga  aacattggg  caatacagg  ccttccgaa  ctgtcgtct  ccattatcc  1440
cgagattga  agtattttg  gcaataaac  ctacagcaa  aaggactac  gatcctaag  1500
cgcccccgc  cgcctgctc  gacagtttc  gttccctcc  agtctctgt  cgctcgctt  1560
agctgtttt  aagcaagtg  agagtgtgg  ttgcatcca  gagaaaaca  cacactgtg  1620
tgtcatcgg  aaatgatct  ccaagtcgc  gccagacac  acccactgc  tcgccggac  1680
atgtcgaag  ccantctgt  ccggggaag  cactggtta  gaaggatgt  caaacggtc  1740
cacccaagc  tgtcacctc  gctcatcct  caagaccac  cagcttttt  ccagccaca  1800
ccaagattc  caaagtcaa  gcccaaaga  ttccaaggt  cccaaagtc  aggccaggc  1860
aaggcctgg  tgggtcctt  gggcgggca  ggccggcct  tcctctgct  agaatcccc  1920
cttggtgta  ggggagagg  aaagggtct  gcccatcga  ggccccttt  tgccaggcc  1980
ttggttgct  gggcaggcc  ccccactgg  ggtcttcct  cacctccca  tttccaagg  2040
ctccaggaa  ctggggcct  accacagat  cctctccca  ccttttctg  tccaacctg  2100
cccactggg  cacggcagg  gccatgcct  ccaagctcg  gctggccct  gacccccac  2160
cacccccac  cttgctggc  ggggcaggg  ccccagggg  attgactct  cagtttggg  2220
gccacaaaa  gcgtagcgg  cgtgatttc  agctcagcc  cccaccgtc  tcctcctac  2280
caccaatga  gagcctcat  ccagtgagg  ccggagcgc  tgggagggg  cccagtggg  2340
caggcccct  tgtctggcc  cccctctgt  ctggccccg  aaggccctg  ggtcatgtg  2400
tcctagctg  acggtggct  ctggcacac  acggcaagt  gcagcaggg  cggcctgtg  2460
acaaggatg  actcctctc  gccctgtag  atttctcta  agccgcccg  cagcccagg  2520
cgctgctct  caccgagct  gtgggcttg  gttttgtgg  gcgcatgct  ggacccttt  2580
agtaaggaa  ggtctttgg  attttctgt  cccatgact  gggggctgc  cccccacag  2640
acccccaca  tgtaggaaa  gacctcagg  aacctctcc  tggaaagac  ggcagggct  2700
gttagcccc  cccactgcc  gacacctgg  acaggctgg  cagagggga  agagggcag  2760
acaggccag  gtgacgccc  cgtgcagct  gggccggag  gcaagggat  ccagtaagt  2820
tgcaggtgc  gggtgccac  tacaggccc  ggcctgtgt  ccaagcagt  cccaggctt  2880
gcagaccac  cggggcagg  ctccactga  gccaccccc  cccctcgcc  gctagctcc  2940
tagggaagc  tgtgtctcc  gcccccagg  cgcaccctc  gtgcaggca  ctctgttcc  3000
gctttgccc  tggaggagc  3019



<210> 7585
<211> 367
<212> PRT
<213> Homo sapiens
<308> Q13303
<400> 7585

Met Tyr Pro Glu Ser Thr Thr Gly Ser Pro Ala Arg Leu Ser Leu Arg 
  1               5                  10                  15
Gln Thr Gly Ser Pro Gly Met Ile Tyr Ser Thr Arg Tyr Gly Ser Pro 
             20                  25                  30
Lys Arg Gln Leu Gln Phe Tyr Arg Asn Leu Gly Lys Ser Gly Leu Arg 
         35                  40                  45
Val Ser Cys Leu Gly Leu Gly Thr Trp Val Thr Phe Gly Gly Gln Ile 
     50                  55                  60
Thr Asp Glu Met Ala Glu Gln Leu Met Thr Leu Ala Tyr Asp Asn Gly 
 65                  70                  75                  80
Ile Asn Leu Phe Asp Thr Ala Glu Val Tyr Ala Ala Gly Lys Ala Glu 
                 85                  90                  95
Val Val Leu Gly Asn Ile Ile Lys Lys Lys Gly Trp Arg Arg Ser Ser 
             100                105                110
Leu Val Ile Thr Thr Lys Ile Phe Trp Gly Gly Lys Ala Glu Thr Glu 
         115                120                125
Arg Gly Leu Ser Arg Lys His Ile Ile Glu Gly Leu Lys Ala Ser Leu 
     130                135                140
Glu Arg Leu Gln Leu Glu Tyr Val Asp Val Val Phe Ala Asn Arg Pro 
 145                150                155                160
Asp Pro Asn Thr Pro Met Glu Glu Thr Val Arg Ala Met Thr His Val 
                 165                170                175
Ile Asn Gln Gly Met Ala Met Tyr Trp Gly Thr Ser Arg Trp Ser Ser 
             180                185                190
Met Glu Ile Met Glu Ala Tyr Ser Val Ala Arg Gln Phe Asn Leu Thr 
         195                200                205
Pro Pro Ile Cys Glu Gln Ala Glu Tyr His Met Phe Gln Arg Glu Lys 
     210                215                220
Val Glu Val Gln Leu Pro Glu Leu Phe His Lys Ile Gly Val Gly Ala 
 225                230                235                240
Met Thr Trp Ser Pro Leu Ala Cys Gly Ile Val Ser Gly Lys Tyr Asp 
                 245                250                255
Ser Gly Ile Pro Pro Tyr Ser Arg Ala Ser Leu Lys Gly Tyr Gln Trp 
             260                265                270
Leu Lys Asp Lys Ile Leu Ser Glu Glu Gly Arg Arg Gln Gln Ala Lys 
         275                280                285
Leu Lys Glu Leu Gln Ala Ile Ala Glu Arg Leu Gly Cys Thr Leu Pro 
     290                295                300
Gln Leu Ala Ile Ala Trp Cys Leu Arg Asn Glu Gly Val Ser Ser Val 
 305                310                315                320
Leu Leu Gly Ala Ser Asn Ala Asp Gln Leu Met Glu Asn Ile Gly Ala 
                 325                330                335
Ile Gln Val Leu Pro Lys Leu Ser Ser Ser Ile Ile His Glu Ile Asp 
             340                345                350
Ser Ile Leu Gly Asn Lys Pro Tyr Ser Lys Lys Asp Tyr Arg Ser 
         355                360                365



<210> 7586
<211> 389
<212> DNA
<213> Rattus norvegicus
<308> H33660
<400> 7586

aagagcttn  taaaactct  tattaatca  attgttaac  tttaataga  cttgagaca  60
aaatctaca  tttaaacag  tatcttatg  taataaaca  taatcctgt  agtnctgtg  120
agaagcagt  actccacat  tagagacct  ggtcaggaa  tggaaccaa  tagattact  180
agggaagga  ttttncgaa  ttagttttg  catgaccaa  ttcagtgtg  tctgaatac  240
tgtgttatt  ctctctact  tagaagaat  tctnccgct  gtttttcca  ttncttctg  300
ttcaagggg  aggagagta  gcgggttga  tagatttcg  ggttccccc  agatgccaa  360
tacgggcat  accacagac  ccagattcg  389



<210> 7587
<211> 1405
<212> DNA
<213> Homo sapiens
<308> AK058044
<400> 7587

agcgacgcc  cgccccgct  cgcgccccg  gcagccgtg  gcaggcgcc  gcgggcggt  60
tcctcggcg  cgccgtatg  ctgccaggg  gaggccatg  accgggtgc  cgagtttta  120
gcgaggagg  agcggttag  tgggcagac  ccttacttg  tggatcagt  gggattacg  180
ttagggatg  ggtactgga  agatgaaac  agaactctt  aattcagaa  gtttgccgc  240
gaagattct  tccagtggc  cctgaaaca  caccctcat  ttacacctg  agcagaagt  300
aaggaaaaa  gaaagaaag  caaagcagt  cactttgca  aaactgatg  tccagcttc  360
gacaggttg  cagataaaa  acttgctgc  aaagatgat  agtcagcta  agctgtaga  420
aaacgaggt  aacagggca  cattacact  gatgatgtt  aatttgtta  tttgctttt  480
ctacaagat  ctgagatgc  gcggatctg  tcttttaca  catttatga  gaataagaa  540
cttgataat  tcctcatgg  attattgta  tacttatcc  attacttgg  aaaaaactc  600
ctggaaaag  aacccaaaa  ctatatggt  ggccttgta  agaaaaaag  aatggaatt  660
gttttaagt  aattagaag  agcacagag  tacttggcg  agaagtact  tatccttgt  720
ctgggcttg  ccgtgccgg  taagcatca  atgtgctgt  gaaaggaga  aatatcaga  780
acacagaaa  actggaagt  ctttgagtc  ttttatact  tctgtacat  tgtggcttg  840
attgtcttc  gacgtcaac  cttgacaga  attgaagaa  aagtaggga  actctttcg  900
accaatatg  tcaacattc  tcgcaggag  cgtgaagat  aggaatcag  aggggaaaa  960
aaacgcatg  cttttgttc  gttcaggag  atgatggca  aacgcccag  aattaaaaa  1020
gctatcaac  tgcgttctc  agtcatgtc  actctgctg  catctctca  agaaaaagc  1080
caaaacgtc  ttgagaaaa  gtatcatca  gtagacgtc  gattcccag  cgagatgca  1140
aagcatgtg  gaactctgg  ctctgtgcc  atgccggta  ttggcatct  gggggagcc  1200
cgatgtcta  tcaacccac  tacgcttca  ccccttgat  cagaagaaa  cacaaaatc  1260
tttgggaga  atccttcct  gatggaaaa  aataacatg  ggattcagg  tacactgga  1320
ttggtcatg  aaacactgt  ctctcatac  tcatgccct  agtaacctg  tacattcca  1380
atctcaagt  aactacttt  acttt  1405



<210> 7588
<211> 423
<212> PRT
<213> Homo sapiens
<308> AK058044
<400> 7588

Met Tyr Arg Val Pro Glu Phe Tyr Ala Arg Arg Lys Arg Leu Gly Gly 
  1               5                  10                  15
Gln Thr Pro Tyr Leu Met Asp Gln Leu Gly Leu Arg Leu Gly Met Trp 
             20                  25                  30
Tyr Trp Lys Asp Glu Thr Arg Thr Leu Glu Phe Arg Arg Phe Ala Ala 
         35                  40                  45
Glu Asp Ser Val Gln Trp Leu Leu Lys His His Pro His Phe Thr Pro 
     50                  55                  60
Ala Ala Glu Val Lys Glu Lys Gly Lys Lys Gly Lys Ala Val His Phe 
 65                  70                  75                  80
Ala Glu Thr Asp Gly Pro Ala Ser Asp Arg Leu Thr Asp Lys Arg Leu 
                 85                  90                  95
Ala Ala Lys Asp Asp Lys Ser Ala Lys Ala Val Glu Lys Arg Gly Gln 
             100                105                110
Gln Gly Thr Ile Thr Leu Asp Asp Val Lys Phe Val Thr Leu Leu Leu 
         115                120                125
Leu Gln Asp Thr Glu Met Gln Arg Ile Cys Ser Phe Thr Thr Phe Met 
     130                135                140
Arg Asn Lys Asn Leu Asp Asn Phe Leu Met Ala Leu Leu Tyr Tyr Leu 
 145                150                155                160
Ser His Tyr Leu Glu Lys Asn Ser Leu Glu Lys Lys Pro Lys Ser Tyr 
                 165                170                175
Met Val Gly Leu Val Glu Lys Lys Glu Met Glu Leu Val Leu Ser Glu 
             180                185                190
Leu Glu Ala Ala Gln Arg Tyr Leu Ala Gln Lys Tyr Cys Ile Leu Val 
         195                200                205
Leu Gly Leu Ala Val Pro Asp Lys His His Met Cys Cys Gly Lys Glu 
     210                215                220
Lys Ile Ser Asp Thr Gln Lys Asp Trp Lys Phe Phe Glu Ser Phe Tyr 
 225                230                235                240
Thr Phe Cys Thr Tyr Val Ala Trp Ile Val Phe Arg Arg Gln His Leu 
                 245                250                255
Thr Glu Ile Glu Glu Glu Val Gly Arg Leu Phe Arg Thr Asn Met Phe 
             260                265                270
Asn Ile Pro Arg Arg Arg Arg Glu Asp Glu Glu Ser Gly Gly Glu Lys 
         275                280                285
Lys Arg Met Thr Phe Val Gln Phe Arg Arg Met Met Ala Lys Arg Pro 
     290                295                300
Ala Ile Lys Lys Ala Ile Asn Met Arg Ser Pro Val Met Ser Thr Leu 
 305                310                315                320
Leu Pro Ser Leu Arg Glu Lys Ala Gln Asn Val Phe Glu Lys Lys Tyr 
                 325                330                335
His Gln Val Asp Val Arg Phe Pro Ala Glu Met Gln Lys His Val Gly 
             340                345                350
Thr Leu Asp Ser Val Pro Met Pro Val Val Gly Ile Leu Gly Glu Pro 
         355                360                365
Arg Cys Leu Phe Asn Pro His Thr Leu His Pro Leu Asp Pro Glu Glu 
     370                375                380
Asn Thr Lys Ser Phe Gly Arg Tyr Pro Ser Leu Met Glu Asn Asn Asn 
 385                390                395                400
Met Arg Ile Gln Asp Thr Leu Asp Leu Val Met Lys Thr Leu Ser Ser 
                 405                410                415
His Thr Ser Cys Pro Lys Ter 
             420



<210> 7589
<211> 2524
<212> DNA
<213> Rattus norvegicus
<308> S45392
<400> 7589

ggcctaggc  tgccgtgcg  gtcggacgt  gtccgggcc  accctgctc  gtactacta  60
tcggctttc  cgtcaagat  cctgaggaa  tgcaccatg  agaggaaga  gtggagacc  120
tcgcctttc  ggcagaaat  gcccagctg  tgtccctca  catcaacac  ttttactca  180
acaaagaga  tttcctccg  gagttgatc  ctaatgctt  tgatgccct  gacaagatt  240
ggtatgaga  cctgactga  ccttccaag  tggacagcg  gaaagagct  aagattgac  300
tcatcccca  ccctcagga  gccacgctg  ctttggtgg  cacaggcat  ggcatgacc  360
aggctgacc  cataaataa  ttgggaacc  ttgctaagt  tggtacaaa  gcgttcatg  420
aggctctcc  ggctggtgc  gacatctcc  tgattgggc  gtttggtgt  ggcttctac  480
ctgcctacc  ggtggcaga  aaagtggtt  tgatcacga  gcacaacga  gatgagcag  540
atgcctggg  gtcttctgc  ggtggatcc  tcactgtcc  tgcagacca  ggtgagccc  600
ttggccggg  taccaaagt  atccttcac  tcaaagaag  ccagacaga  tacttagag  660
agaggaggg  caaggaggt  gtgaagaaa  actcacagt  cataggcta  cccatcacc  720
tctatctgg  gaaggaacg  gagaaggag  tcagtgatg  tgaggcaga  gaagagaaa  780
gggagaagg  ggaggaaga  aaggaggat  aggagaagc  taagattga  gatgtggga  840
ctgatgagg  ggatgacag  ggcaaagat  agaaaaaga  aacaaagaa  atcaaggag  900
agtacattg  ccaggaaga  ctgaataag  cgaagccca  ctggaccag  aatcctgat  960
acatcactc  agaggaata  ggtgaattc  acaagagcc  caccaatga  tgggaagac  1020
acttggcag  caagcactt  tctgtagaa  ggcagttgg  attcagggc  ttgctcttc  1080
ttccccggc  agctccctt  gacctcttt  agaacaaga  gaagaagaa  aacatcaaa  1140
tgtatgtcc  tcgtgtgtt  atcatggac  gctgtgatg  cctgatacc  gagtacctc  1200
acttcatcc  tggtgtggt  gattccgag  acctgcctc  gaacatctc  cgagaaatg  1260
tccagcaga  caagatcct  aaagtcatc  gcaaaaaca  tgtgaagaa  tgccttgag  1320
tcttctctg  gttggctga  gacaaagag  actacaaga  attttatga  gcattctct  1380
agaatttaa  gcttggaat  catgaggat  ccactaacc  tcgccgcct  tctgagctc  1440
ttcgctacc  tacctctca  tctggagat  agatgactt  cctgtcaga  tatgtgtct  1500
gcatgaagg  gacacagaa  tccatctac  atatcactg  tgagagcaa  gagcaggtg  1560
ccaactctg  cttcgtgga  cgtgtgcgg  aacggggct  tgaggtggt  tacatgact  1620
agcccattg  tgagtactg  gtacagcag  tcaaggagt  cgatggcaa  agcctggtc  1680
ccgtgacca  ggagggcct  gagctacca  aggatgagg  agagaagaa  aaaatggag  1740
agagcaagg  aaggtttga  aatctctgc  agctcatga  ggagatctt  gacaagaag  1800
ttgaaaaag  gactatctc  aataggctt  tgtcttccc  ctgctgcat  gtgaccagc  1860
cctacggct  gacagccaa  atggaacgg  ttatgaagg  ccaggcact  cgggacaac  1920
cgacaatgg  ctacatgat  gccaagaaa  acctagaga  caaccctga  caccccatt  1980
tggagactc  gcggcagaa  gctgaggca  acaaaaacg  caaagctgt  aaagacctg  2040
tggtgctgc  gtttgagac  gctctgtct  ctctcgctt  tcactttag  aggcccaaa  2100
cccactcca  ccgcatcta  cgcatgatt  aactaggcc  gggcattga  gaagatgag  2160
tcactgcag  agagcccag  gctgctgtt  ccgatgaga  ccccccact  gagggtgat  2220
aggatgcct  tcgcatgga  gaagtggat  aaaggctcc  gggaagccc  cgccctctg  2280
atagtatcc  tgtggctcc  ccaacagcc  tgactggcc  tgacccacc  gggctctct  2340
tgctcatgt  tacaagaat  tcttctatc  tgtccttgt  ccttaaggc  ggaagatcc  2400
ctcccacag  tagcagggt  gggtgttgt  tattgtgtt  ttttgtttg  tttattttg  2460
tctgaaatt  aaagtatgc  aaataaaga  gatgcagtt  taaaaaaaa  aaaaaaaaa  2520
aagg  2524



<210> 7590
<211> 723
<212> PRT
<213> Rattus norvegicus
<308> AAB23369
<400> 7590

Pro Glu Glu Val His His Gly Glu Glu Glu Val Glu Thr Phe Ala Phe 
  1               5                  10                  15
Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe Tyr 
             20                  25                  30
Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp 
         35                  40                  45
Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys Leu 
     50                  55                  60
Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile Pro Asn Pro Gln Glu 
 65                  70                  75                  80
Ala Thr Leu Thr Leu Val Asp Thr Gly Ile Gly Met Thr Lys Ala Asp 
                 85                  90                  95
Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala Phe 
             100                105                110
Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln Phe 
         115                120                125
Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Val Val 
     130                135                140
Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser Ala 
 145                150                155                160
Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly Glu Pro Ile Gly Arg 
                 165                170                175
Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr Leu 
             180                185                190
Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys His Ser Gln Phe Ile 
         195                200                205
Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu Arg Glu Lys Glu Ile 
     210                215                220
Ser Asp Asp Glu Ala Glu Glu Glu Lys Gly Glu Lys Glu Glu Glu Asp 
 225                230                235                240
Lys Glu Asp Glu Glu Lys Pro Lys Ile Glu Asp Val Gly Ser Asp Glu 
                 245                250                255
Glu Asp Asp Ser Gly Lys Asp Lys Lys Lys Lys Thr Lys Lys Ile Lys 
             260                265                270
Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile Trp 
         275                280                285
Thr Arg Asn Pro Asp Asp Ile Thr Gln Glu Glu Tyr Gly Glu Phe Tyr 
     290                295                300
Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His Phe 
 305                310                315                320
Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Ile Pro Arg 
                 325                330                335
Arg Ala Pro Phe Asp Leu Phe Glu Asn Lys Lys Lys Lys Asn Asn Ile 
             340                345                350
Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Ser Cys Asp Asp Leu 
         355                360                365
Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp Ser Glu Asp 
     370                375                380
Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser Lys Ile Leu 
 385                390                395                400
Lys Val Ile Arg Lys Asn Ile Val Lys Lys Cys Leu Glu Leu Phe Ser 
                 405                410                415
Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr Glu Ala Phe 
             420                425                430
Ser Lys Asn Leu Lys Leu Gly Ile His Glu Asp Ser Thr Asn Arg Arg 
         435                440                445
Arg Leu Ser Glu Leu Leu Arg Tyr His Thr Ser Gln Ser Gly Asp Glu 
     450                455                460
Met Thr Ser Leu Ser Glu Tyr Val Ser Arg Met Lys Glu Thr Gln Lys 
 465                470                475                480
Ser Ile Tyr Tyr Ile Thr Gly Glu Ser Lys Glu Gln Val Ala Asn Ser 
                 485                490                495
Ala Phe Val Glu Arg Val Arg Lys Arg Gly Phe Glu Val Val Tyr Met 
             500                505                510
Thr Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys Glu Phe Asp 
         515                520                525
Gly Lys Ser Leu Val Ser Val Thr Lys Glu Gly Leu Glu Leu Pro Glu 
     530                535                540
Asp Glu Glu Glu Lys Lys Lys Met Glu Glu Ser Lys Ala Arg Phe Glu 
 545                550                555                560
Asn Leu Cys Lys Leu Met Lys Glu Ile Leu Asp Lys Lys Val Glu Lys 
                 565                570                575
Val Thr Ile Ser Asn Arg Leu Val Ser Ser Pro Cys Cys Ile Val Thr 
             580                585                590
Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala Gln 
         595                600                605
Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Met Ala Lys Lys His 
     610                615                620
Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg Gln Lys 
 625                630                635                640
Ala Glu Ala Asp Lys Asn Asp Lys Ala Val Lys Asp Leu Val Val Leu 
                 645                650                655
Leu Phe Glu Thr Ala Leu Ser Ser Leu Ala Ser His Phe Arg Arg Pro 
             660                665                670
Lys Thr His Ser Asn Arg Ile Tyr Arg Met Ile Lys Leu Gly Leu Gly 
         675                680                685
Ile Asp Glu Asp Glu Val Thr Ala Glu Glu Pro Ser Ala Ala Val Pro 
     690                695                700
Asp Glu Ile Pro Pro Leu Glu Gly Asp Glu Asp Ala Ser Arg Met Glu 
 705                710                715                720
Glu Val Asp 
                 725



<210> 7591
<211> 2567
<212> DNA
<213> Homo sapiens
<308> NM_007355
<400> 7591

ctccggcgc  gtgttggga  tgtctgggt  tcggaaagc  agcctacgt  gctcactat  60
acgtataat  cttttcttt  caagatgcc  gaggaagtg  accatggag  ggaggaggt  120
gagactttt  cctttcagg  agaaattgc  caactcatg  ccctcatca  caatacctt  180
tattccaac  aggagattt  ccttcggga  ttgatctct  atgcttctg  tgccttgga  240
aagattcgc  atgagagcc  gacagaccc  tcgaagttg  acagtggta  agagctgaa  300
attgacatc  tccccaacc  tcaggaacg  accctgact  tggtagaca  aggcattgg  360
atgaccaaa  ctgatctca  aaataattt  ggaaccatt  ccaagtctg  tactaaagc  420
ttcatggag  ctcttcagg  tggtgcaga  atctccatg  ttgggcagt  tggtgttgg  480
ttttattct  cctacttgg  ggcagagaa  gtggttgtg  tcacaaagc  caacgatga  540
gaacagtat  cttgggagt  ttctgctgg  ggttccttc  ctgtgcgtg  tgaccatgg  600
gagcccatt  gcaggggta  caaagtgat  ctccatctt  aagaagatc  gacagagta  660
ctagaagag  ggcgggtca  agaagtagt  aagaagcat  ctcagttca  aggctatcc  720
atcaccctt  atttggaga  ggaacgaga  aaggaaatt  gtgatgatg  ggcagagga  780
gagaaaggt  agaaagaag  ggaagataa  gatgatgaa  aaaaaccca  gatcgaaga  840
gtgggttca  atgaggagg  tgacagcgg  aaggataag  agaagaaaa  taagaagat  900
aaagagaaa  acattgatc  ggaagaact  aacaagacc  agcctattt  gaccagaaa  960
cctgatgac  tcacccaag  ggagtatgg  gaattctac  agagcctca  taatgactg  1020
gaagaccac  tggcagtca  gcacttttc  gtagaaggt  agttggaat  cagggcatt  1080
ctatttatt  ctcgtcggg  tccctttga  ctttttgag  acaagaaga  aaagaacaa  1140
atcaaactc  atgtccgcc  tgtgttcat  atggacagc  gtgatgagt  gataccaga  1200
tatctcaat  ttatccgtg  tgtggttga  tctgaggat  tgcccctga  catctcccg  1260
gaaatgctc  agcagagca  aatcttgaa  gtcattcgc  aaaacattg  taagaagtg  1320
cttgagctc  tctctgagc  ggcagaaga  aaggagaat  acaagaaat  ctatgaggc  1380
ttctctaaa  atctcaagc  tggaatcca  gaagactcc  ctaaccgcc  ccgcctgtc  1440
gagctgctg  gctatcata  ctcccagtc  ggagatgag  tgacatctc  gtcagagta  1500
gtttctcgc  tgaaggaga  acagaagtc  atctattac  tcactggtg  gagcaaaga  1560
caggtggcc  actcagctt  tgtggagcg  gtgcggaaa  ggggcttcg  ggtggtata  1620
atgaccgag  ccattgacg  gtactgtgt  cagcagctc  aggaatttg  tgggaagag  1680
ctggtctca  ttaccaagg  gggtctgga  ctgcctgag  atgaggagg  gaagaagaa  1740
atggaagag  gcaaggcaa  gtttgagaa  ctctgcaag  tcatgaaag  aatcttaga  1800
aagaaggtt  agaaggtga  aatctccaa  agacttgtg  cttcacctt  ctgcattgt  1860
accagcacc  acggctgga  agccaatat  gagcggatc  tgaaagccc  ggcacttcg  1920
gacaactcc  ccatgggct  tatgatggc  aaaaagcac  tggagatca  ccctgacca  1980
cccattgtg  agacgctgc  gcagaaggc  gaggccgac  agaatgata  ggcagttaa  2040
gacctggtg  tgctgctgt  tgaaaccgc  ctgctatct  ctggctttt  ccttgagga  2100
ccccagacc  actccaacc  catctatcg  atgatcaag  taggtctag  tattgatga  2160
gatgaagtg  cagcagagg  acccaatgc  gcagttcct  atgagatcc  ccctctcga  2220
ggcgatgag  atgcgtctc  catggaaga  gtcgattag  ttaggagtt  atagttgga  2280
aacttgtgc  cttgtatag  gtccccatg  gctcccact  cagcctcga  tgcccctgt  2340
ccacctggc  ccccctgct  gtgtctagt  tttttttcc  tctcctgtc  ttgtgttga  2400
ggcagtaaa  taagggtgt  aagccccat  ccctctcta  tcttgacag  aggattgga  2460
gttgtgtat  gtggtttat  ttattttct  cattttgtt  tgaaattaa  gtatgcaaa  2520
taaagaata  gccgtttta  aaaaaaaaa  aaaaaaaaa  aaaaaaa  2567



<210> 7592
<211> 723
<212> PRT
<213> Homo sapiens
<308> P08238
<400> 7592

Pro Glu Glu Val His His Gly Glu Glu Glu Val Glu Thr Phe Ala Phe 
  1               5                  10                  15
Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe Tyr 
             20                  25                  30
Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp 
         35                  40                  45
Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys Leu 
     50                  55                  60
Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile Pro Asn Pro Gln Glu 
 65                  70                  75                  80
Arg Thr Leu Thr Leu Val Asp Thr Gly Ile Gly Met Thr Lys Ala Asp 
                 85                  90                  95
Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala Phe 
             100                105                110
Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln Phe 
         115                120                125
Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Val Val 
     130                135                140
Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser Ala 
 145                150                155                160
Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly Glu Pro Ile Gly Arg 
                 165                170                175
Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr Leu 
             180                185                190
Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys His Ser Gln Phe Ile 
         195                200                205
Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu Arg Glu Lys Glu Ile 
     210                215                220
Ser Asp Asp Glu Ala Glu Glu Glu Lys Gly Glu Lys Glu Glu Glu Asp 
 225                230                235                240
Lys Asp Asp Glu Glu Lys Pro Lys Ile Glu Asp Val Gly Ser Asp Glu 
                 245                250                255
Glu Asp Asp Ser Gly Lys Asp Lys Lys Lys Lys Thr Lys Lys Ile Lys 
             260                265                270
Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile Trp 
         275                280                285
Thr Arg Asn Pro Asp Asp Ile Thr Gln Glu Glu Tyr Gly Glu Phe Tyr 
     290                295                300
Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His Phe 
 305                310                315                320
Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Ile Pro Arg 
                 325                330                335
Arg Ala Pro Phe Asp Leu Phe Glu Asn Lys Lys Lys Lys Asn Asn Ile 
             340                345                350
Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Ser Cys Asp Glu Leu 
         355                360                365
Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp Ser Glu Asp 
     370                375                380
Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser Lys Ile Leu 
 385                390                395                400
Lys Val Ile Arg Lys Asn Ile Val Lys Lys Cys Leu Glu Leu Phe Ser 
                 405                410                415
Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr Glu Ala Phe 
             420                425                430
Ser Lys Asn Leu Lys Leu Gly Ile His Glu Asp Ser Thr Asn Arg Arg 
         435                440                445
Arg Leu Ser Glu Leu Leu Arg Tyr His Thr Ser Gln Ser Gly Asp Glu 
     450                455                460
Met Thr Ser Leu Ser Glu Tyr Val Ser Arg Met Lys Glu Thr Gln Lys 
 465                470                475                480
Ser Ile Tyr Tyr Ile Thr Gly Glu Ser Lys Glu Gln Val Ala Asn Ser 
                 485                490                495
Ala Phe Val Glu Arg Val Arg Lys Arg Gly Phe Glu Val Val Tyr Met 
             500                505                510
Thr Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys Glu Phe Asp 
         515                520                525
Gly Lys Ser Leu Val Ser Val Thr Lys Glu Gly Leu Glu Leu Pro Glu 
     530                535                540
Asp Glu Glu Glu Lys Lys Lys Met Glu Glu Ser Lys Ala Lys Phe Glu 
 545                550                555                560
Asn Leu Cys Lys Leu Met Lys Glu Ile Leu Asp Lys Lys Val Glu Lys 
                 565                570                575
Val Thr Ile Ser Asn Arg Leu Val Ser Ser Pro Cys Cys Ile Val Thr 
             580                585                590
Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala Gln 
         595                600                605
Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Met Ala Lys Lys His 
     610                615                620
Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg Gln Lys 
 625                630                635                640
Ala Glu Ala Asp Lys Asn Asp Lys Ala Val Lys Asp Leu Val Val Leu 
                 645                650                655
Leu Phe Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp Pro 
             660                665                670
Gln Thr His Ser Asn Arg Ile Tyr Arg Met Ile Lys Leu Gly Leu Gly 
         675                680                685
Ile Asp Glu Asp Glu Val Ala Ala Glu Glu Pro Asn Ala Ala Val Pro 
     690                695                700
Asp Glu Ile Pro Pro Leu Glu Gly Asp Glu Asp Ala Ser Arg Met Glu 
 705                710                715                720
Glu Val Asp 
                 725



<210> 7593
<211> 2104
<212> DNA
<213> Rattus norvegicus
<308> S45812
<400> 7593

gcccaatct  gcaggccac  tgttcgacg  agtcgtgat  ggaggcggc  tctcaggat  60
ggctgctgc  aaactgttg  ctgaataca  aattaatgt  ttggttttg  aagcccggg  120
tagagttgg  ggaagaaca  atactgtga  gaatgagca  gtcaaatgg  tagatgttg  180
tggagccta  gtgggacca  cccagaaca  aatcttacg  ttgtctaag  agctaggca  240
agagaccta  aaagtgaat  tcaatgagc  tctagttca  tatgtcaag  ggaaaactt  300
cccattccg  ggtgcattc  cacctgtgt  gaacccctt  gcatatttg  attacaaca  360
cctatggag  acaatggat  aaatgggaa  agagatccc  gttgatgca  cgtggcaag  420
aagacacgc  caggaatgg  acaagatga  catgaaaga  ctcattgat  aaatctgtt  480
gacaaaaac  gctcgggaa  ttgcgtatc  ttttgtgaa  attaatgtg  cttctgagc  540
tcatgaggt  tctgccctg  ggttcctgt  gtatgtgag  cagtgtggg  gcactgctc  600
gatattctc  gtcaccaat  gcggccagg  acggaaatt  gtaggtgga  ctggccaag  660
aagtgaaca  ataatgggt  tccttggag  taaagtgaa  ctgagctct  ctgttactt  720
tattgacca  acagatgac  acatcattg  agaaacact  aatcatgaa  actatgagt  780
caaatacgt  attagtgcc  tcccaccga  tttgactgc  aagatccac  ttaaaccag  840
gcttccacc  gagagaaac  aattaattc  gcgtcttcc  atgggggct  ttatcaagt  900
catggtgta  tacaaggaa  ccttctgga  gaaaaagga  tattgtggc  gcatgatca  960
tgaagatga  gaggctcca  tcgccatca  tctggatga  actaaacca  atgggtcac  1020
gcctgccat  atgggcttc  tacttgccc  gaaagctga  cgacttgct  aactacata  1080
agacataag  aagaggaaa  tctgtgagc  gtatgccaa  gttctggga  ctcaagaag  1140
attatatcc  gtccattat  aagagaaga  ctggtgtga  gagcagtac  ccgggggct  1200
gtacacagc  tacttccct  ctggtatca  gacccagta  ggaagggtg  ttcgccagc  1260
agtaggtag  atttacttt  caggcacag  gacagcaac  cagtggagt  gctacatgg  1320
aggagcagt  gaacgtgga  aacgagcag  tagagaggt  ttgaatgct  taggaaaag  1380
cgcgaagaa  gatatatgg  ttgaagaac  cgagtccaa  gatgttcca  ccattgaaa  1440
tacccacac  ttcttagag  ggaacctgc  ttccgtgcc  ggtctgctc  agatcactg  1500
tgtttccac  tctgtggct  ttctctgct  tgtattgta  aagattaag  agctcccat  1560
ctgaagttt  accctcagg  ctcctgcac  atcatcgca  gtgaaagaa  gtgtggata  1620
attacagcc  atggtttgg  ccatttaag  gcacttgat  taaccctca  cagtttaat  1680
tcagtcttt  taaagtgat  acaatccaa  gaatcacct  gctaatttc  ataagaaca  1740
gtttcatcc  gtttgttag  ctaatttgt  tgggttgag  gaataaaat  ttgagtgct  1800
aatttcaaa  agtgaagtg  ttctgagga  taatttctg  gttcttttg  tttcttttt  1860
cctttaatg  aaaatagct  attcagaaa  aaaacactt  acttactgt  acttttgtg  1920
agcgtccaa  gtgtacaga  gaaaatagt  gctgaagtg  tccctaggt  tcctcactg  1980
ctagctcca  gtgatacac  ctacccttg  cactttctt  tctggactg  atctagaca  2040
gcattgacc  ttgtcagta  cattctgtg  tcatttaag  aaattagca  tattttaat  2100
tagt  2104



<210> 7594
<211> 1949
<212> DNA
<213> Homo sapiens
<308> M68840
<400> 7594

catagaagg  tccttccca  cctttgccg  ccccactcc  gtgcctacg  cccaggagc  60
tgtcagcca  atcatggag  atcaagaga  ggcgagtat  gcgggccac  tgttcgacg  120
agtcgtgat  ggaggtggc  tttcaggac  atctgctgc  aaactcttg  ctgaatatg  180
cgttagtgt  ttggtttta  aagctcggg  cagggttgg  ggaagaaca  atactataa  240
gaatgagca  gttgattac  tagatgttg  tggagctta  gtgggacca  cccaaaaca  300
aatcttacg  ttgtctaag  agctgggca  agagactta  aaagtgaat  tcagtgagc  360
tctcgttca  tatgtcaag  ggaaaacat  tccatttcg  ggcgccttt  caccagtat  420
gaatcccat  gcatatttg  attacaata  tctgtggag  acaatagat  acatgggga  480
ggagattcc  actgatgca  cctgggagg  tcaacatgc  gacaaatgg  acaaaatga  540
catgaaaga  ctcattgac  aaatctgct  gacaaagac  gctaggcgg  ttgcttatc  600
ttttgtgaa  atcaatgtg  cctctgagc  tcacgaagt  tctgccctg  ggttcttgt  660
gtatgtgaa  cagtgcggg  gcaccactc  gatattctc  gtcaccaat  gtggccagg  720
acggaagtt  gtaggtgga  ctggtcaag  gagcgaacg  ataatggac  tcctcggag  780
ccaagtgaa  ctgaaccat  ctgtcactc  cgttgacca  tcaagtgac  acatcatca  840
agagacgct  aaccatgaa  attatgagt  caaatacgt  attaatgcg  tccctccga  900
cttgactgc  aagattcac  tcagaccag  gcttccagc  gagagaaac  agttaattc  960
gcggcttcc  atgggagct  tcattaagt  catgatgta  tacaaggag  ccttctgga  1020
gaagaagga  tactgtggc  gcatgatca  tgaagatga  gatgctcca  tttcaataa  1080
cttggatga  accaagcct  atgggtcac  gcctgccat  atgggcttc  ttcttgccc  1140
gaaagctga  cgacttgct  agctacata  ggaaataag  aagaagaaa  tctgtgagc  1200
ctatgccaa  gtgctggga  cccaagaag  tttacatcc  gtgcattat  aagagaaga  1260
ctggtgtga  gagcagtac  ctgggggct  ctacacggc  tacttccct  ctgggatca  1320
gactcaata  ggaagggtg  ttcgtcaac  cgtgggcag  attttcttt  cgggcacag  1380
gactgccac  aagtggagc  gctacatgg  aggggcagt  gaggctgga  aacgagcag  1440
tagggaggt  ttaaatggt  tcgggaagg  gaccgagaa  gatatctgg  tacaagaac  1500
tgaatcaaa  gacgttcca  cggtagaaa  cacccacac  ttctgggaa  ggaacctgc  1560
ctctgtttc  ggcctgctg  agatcattg  attttccac  tcagtaact  ccctggggt  1620
tgtgctgta  aaatacaag  tcctgccac  gtcttgaag  tctgttctt  tgctctctg  1680
tcactggtt  tcaatacca  caagaggaa  aatattgac  agtttaaag  ctgtgtcat  1740
gggccatgt  taagtgtac  ggatttaac  acctttggc  taattccaa  cattgttaa  1800
gtaaaaaca  ttcaaagaa  cacctaatt  atttcagta  atcaagctc  atcttattt  1860
tcagtgtag  tcactcatg  taattgata  aataaagcc  tgtgatcat  tctgaaatt  1920
acaagtaac  tgtatgtgc  catcagaac  1949



<210> 7595
<211> 527
<212> PRT
<213> Homo sapiens
<308> P21397
<400> 7595

Met Glu Asn Gln Glu Lys Ala Ser Ile Ala Gly His Met Phe Asp Val 
  1               5                  10                  15
Val Val Ile Gly Gly Gly Ile Ser Gly Leu Ser Ala Ala Lys Leu Leu 
             20                  25                  30
Thr Glu Tyr Gly Val Ser Val Leu Val Leu Glu Ala Arg Asp Arg Val 
         35                  40                  45
Gly Gly Arg Thr Tyr Thr Ile Arg Asn Glu His Val Asp Tyr Val Asp 
     50                  55                  60
Val Gly Gly Ala Tyr Val Gly Pro Thr Gln Asn Arg Ile Leu Arg Leu 
 65                  70                  75                  80
Ser Lys Glu Leu Gly Ile Glu Thr Tyr Lys Val Asn Val Ser Glu Arg 
                 85                  90                  95
Leu Val Gln Tyr Val Lys Gly Lys Thr Tyr Pro Phe Arg Gly Ala Phe 
             100                105                110
Pro Pro Val Trp Asn Pro Ile Ala Tyr Leu Asp Tyr Asn Asn Leu Trp 
         115                120                125
Arg Thr Ile Asp Asn Met Gly Lys Glu Ile Pro Thr Asp Ala Pro Trp 
     130                135                140
Glu Ala Gln His Ala Asp Lys Trp Asp Lys Met Thr Met Lys Glu Leu 
 145                150                155                160
Ile Asp Lys Ile Cys Trp Thr Lys Thr Ala Arg Arg Phe Ala Tyr Leu 
                 165                170                175
Phe Val Asn Ile Asn Val Thr Ser Glu Pro His Glu Val Ser Ala Leu 
             180                185                190
Trp Phe Leu Trp Tyr Val Lys Gln Cys Gly Gly Thr Thr Arg Ile Phe 
         195                200                205
Ser Val Thr Asn Gly Gly Gln Glu Arg Lys Phe Val Gly Gly Ser Gly 
     210                215                220
Gln Val Ser Glu Arg Ile Met Asp Leu Leu Gly Asp Gln Val Lys Leu 
 225                230                235                240
Asn His Pro Val Thr His Val Asp Gln Ser Ser Asp Asn Ile Ile Ile 
                 245                250                255
Glu Thr Leu Asn His Glu His Tyr Glu Cys Lys Tyr Val Ile Asn Ala 
             260                265                270
Ile Pro Pro Thr Leu Thr Ala Lys Ile His Phe Arg Pro Glu Leu Pro 
         275                280                285
Ala Glu Arg Asn Gln Leu Ile Gln Arg Leu Pro Met Gly Ala Val Ile 
     290                295                300
Lys Cys Met Met Tyr Tyr Lys Glu Ala Phe Trp Lys Lys Lys Asp Tyr 
 305                310                315                320
Cys Gly Cys Met Ile Ile Glu Asp Glu Asp Ala Pro Ile Ser Ile Thr 
                 325                330                335
Leu Asp Asp Thr Lys Pro Asp Gly Ser Leu Pro Ala Ile Met Gly Phe 
             340                345                350
Ile Leu Ala Arg Lys Ala Asp Arg Leu Ala Lys Leu His Lys Glu Ile 
         355                360                365
Arg Lys Lys Lys Ile Cys Glu Leu Tyr Ala Lys Val Leu Gly Ser Gln 
     370                375                380
Glu Ala Leu His Pro Val His Tyr Glu Glu Lys Asn Trp Cys Glu Glu 
 385                390                395                400
Gln Tyr Ser Gly Gly Cys Tyr Thr Ala Tyr Phe Pro Pro Gly Ile Met 
                 405                410                415
Thr Gln Tyr Gly Arg Val Ile Arg Gln Pro Val Gly Arg Ile Phe Phe 
             420                425                430
Ala Gly Thr Glu Thr Ala Thr Lys Trp Ser Gly Tyr Met Glu Gly Ala 
         435                440                445
Val Glu Ala Gly Glu Arg Ala Ala Arg Glu Val Leu Asn Gly Leu Gly 
     450                455                460
Lys Val Thr Glu Lys Asp Ile Trp Val Gln Glu Pro Glu Ser Lys Asp 
 465                470                475                480
Val Pro Ala Val Glu Ile Thr His Thr Phe Trp Glu Arg Asn Leu Pro 
                 485                490                495
Ser Val Ser Gly Leu Leu Lys Ile Ile Gly Phe Ser Thr Ser Val Thr 
             500                505                510
Ala Leu Gly Phe Val Leu Tyr Lys Tyr Lys Leu Leu Pro Arg Ser 
         515                520                525



<210> 7596
<211> 2190
<212> DNA
<213> Rattus norvegicus
<308> S46785
<400> 7596

gctgccagc  acaggcagt  gggaaatcc  cagggcagc  gctgtattg  agacggccc  60
tgctcactg  ctgcctgca  ccagctctg  acaaggaac  atggccctg  ggacaggag  120
cccagccct  gtggtgctt  tggctttct  ggtggcact  ggcccctgt  acctgcagg  180
gacagatcc  ggagcgtcg  cagatgccg  gggccccca  tgccccgtc  cctgtacct  240
cagccatga  gactacaca  atgagctca  cgtcttttg  agttcaaag  acctcacac  300
tctgcctga  gacatccca  tcagcacca  agccctgtg  cttgatggc  acaacctct  360
ttctatccc  tcagcggcc  tccagaacc  gtccagcct  gactttctc  acctgcagg  420
cagctggct  aggagcctg  agccacagg  actgctggg  ctgcagaac  tctactatc  480
gcacctgga  cggaaccgg  tccggaacc  cgccgtggg  ttgttcaca  acacaccga  540
tctggcttc  ctcagcctg  gcagcaacc  cttgggccg  ctggaggaa  ggctgttcc  600
gggcctcag  cacctttgg  acctcaacc  gggttggaa  agtctagtg  tcctgcctg  660
cacagtgtt  cagggactg  gcaacctcc  cgagctggt  ctggctggc  acaaactga  720
ttacctgca  cctgcgctc  tctgtggct  gggcgagct  cgggagctg  atctgagca  780
gaacgcact  cgaagcgtc  aagctaacg  ctttgtaca  ttgcccagg  tgcagaagc  840
gtacctgga  cggaacctc  ttacagccg  ggcccctgg  gcctttctg  gcatgaagg  900
cctgcgttg  ctggacctg  cgcacaacc  cgtggctgg  ctcatggag  acaccttcc  960
aggcctgct  ggcctgcac  tcctgcgcc  ggcacacaa  gcgatcgct  gcttgcggc  1020
gcgcacttt  aaagacctg  acttcctgg  ggaactgca  ctgggccac  atcgaatca  1080
gcagctcgg  gagaggaca  tcgagggcc  ggggcagct  gaggtgctg  cgctcaatg  1140
caaccagat  actgaggtc  gggtgggcg  cttctctgg  cttttcaat  tggcggtta  1200
gaatctctc  ggcaactgt  tgaggagcc  cccggagcg  gtgtttcag  gtctggaca  1260
actgcacag  ctgcaccta  agcacagct  cctgggtca  gtccgcctg  acacttttg  1320
tggcctctc  gggctgcgc  ggctcttcc  cagggacaa  agcatctcc  gcatcgaag  1380
acagagcct  gcagggctt  cggagctcc  ggaactgga  cttactacc  accgcctca  1440
acatctgcc  cgccagctc  tccagggcc  cggccacct  gagtacctg  ttctctcct  1500
caaccaact  acgacttta  ccgcggagg  cctgggccc  ctgcagcgg  ccttctggt  1560
ggatatctc  cacaaccac  tggagacgc  ggccgaagg  cttttctca  ctctggggc  1620
cgttcgcta  ctcagcctc  ggaataact  cttgcagac  ttttcacca  agcccggcc  1680
ggagcgcct  tggcttgat  ccaacccct  ggactgcag  tgtcccctc  aggcgcttc  1740
agactttgc  ctgcagaac  ctggtgttg  cccccgctt  gttcagact  tctgtgagg  1800
ggacgactg  cagccggtg  acacctaca  caatatcac  tgcgctggc  ccgccaacg  1860
ctcgggcct  gacctaaga  acgttagtg  aacacattt  gtgcactgc  gacactggc  1920
acttactgg  ccggtctgg  cgaacactg  ctcatggcc  ggacggtgt  tcattgtta  1980
cagaataag  tggctctca  attcctacc  atctctagg  gacaggtcc  ggctgctca  2040
ttcctggaa  caggctgta  tggaagcta  gtggcctag  aagggtggg  tcaggccaa  2100
tgtccaagg  cccaaagga  ggaggtgct  gctgaattt  agcatatta  tcagcggag  2160
aaaagaaac  aaccaggat  ccctcagtaa  2190



<210> 7597
<211> 603
<212> PRT
<213> Rattus norvegicus
<308> P35859
<400> 7597

Met Ala Leu Arg Thr Gly Gly Pro Ala Leu Val Val Leu Leu Ala Phe 
  1               5                  10                  15
Trp Val Ala Leu Gly Pro Cys His Leu Gln Gly Thr Asp Pro Gly Ala 
             20                  25                  30
Ser Ala Asp Ala Glu Gly Pro Gln Cys Pro Val Ala Cys Thr Cys Ser 
         35                  40                  45
His Asp Asp Tyr Thr Asp Glu Leu Ser Val Phe Cys Ser Ser Lys Asn 
     50                  55                  60
Leu Thr His Leu Pro Asp Asp Ile Pro Val Ser Thr Arg Ala Leu Trp 
 65                  70                  75                  80
Leu Asp Gly Asn Asn Leu Ser Ser Ile Pro Ser Ala Ala Phe Gln Asn 
                 85                  90                  95
Leu Ser Ser Leu Asp Phe Leu Asn Leu Gln Gly Ser Trp Leu Arg Ser 
             100                105                110
Leu Glu Pro Gln Ala Leu Leu Gly Leu Gln Asn Leu Tyr Tyr Leu His 
         115                120                125
Leu Glu Arg Asn Arg Leu Arg Asn Leu Ala Val Gly Leu Phe Thr His 
     130                135                140
Thr Pro Ser Leu Ala Ser Leu Ser Leu Ser Ser Asn Leu Leu Gly Arg 
 145                150                155                160
Leu Glu Glu Gly Leu Phe Gln Gly Leu Ser His Leu Trp Asp Leu Asn 
                 165                170                175
Leu Gly Trp Asn Ser Leu Val Val Leu Pro Asp Thr Val Phe Gln Gly 
             180                185                190
Leu Gly Asn Leu His Glu Leu Val Leu Ala Gly Asn Lys Leu Thr Tyr 
         195                200                205
Leu Gln Pro Ala Leu Phe Cys Gly Leu Gly Glu Leu Arg Glu Leu Asp 
     210                215                220
Leu Ser Arg Asn Ala Leu Arg Ser Val Lys Ala Asn Val Phe Val His 
 225                230                235                240
Leu Pro Arg Leu Gln Lys Leu Tyr Leu Asp Arg Asn Leu Ile Thr Ala 
                 245                250                255
Val Ala Pro Gly Ala Phe Leu Gly Met Lys Ala Leu Arg Trp Leu Asp 
             260                265                270
Leu Ser His Asn Arg Val Ala Gly Leu Met Glu Asp Thr Phe Pro Gly 
         275                280                285
Leu Leu Gly Leu His Val Leu Arg Leu Ala His Asn Ala Ile Ala Ser 
     290                295                300
Leu Arg Pro Arg Thr Phe Lys Asp Leu His Phe Leu Glu Glu Leu Gln 
 305                310                315                320
Leu Gly His Asn Arg Ile Arg Gln Leu Gly Glu Arg Thr Phe Glu Gly 
                 325                330                335
Leu Gly Gln Leu Glu Val Leu Thr Leu Asn Asp Asn Gln Ile Thr Glu 
             340                345                350
Val Arg Val Gly Ala Phe Ser Gly Leu Phe Asn Val Ala Val Met Asn 
         355                360                365
Leu Ser Gly Asn Cys Leu Arg Ser Leu Pro Glu Arg Val Phe Gln Gly 
     370                375                380
Leu Asp Lys Leu His Ser Leu His Leu Glu His Ser Cys Leu Gly His 
 385                390                395                400
Val Arg Leu His Thr Phe Ala Gly Leu Ser Gly Leu Arg Arg Leu Phe 
                 405                410                415
Leu Arg Asp Asn Ser Ile Ser Ser Ile Glu Glu Gln Ser Leu Ala Gly 
             420                425                430
Leu Ser Glu Leu Leu Glu Leu Asp Leu Thr Thr Asn Arg Leu Thr His 
         435                440                445
Leu Pro Arg Gln Leu Phe Gln Gly Leu Gly His Leu Glu Tyr Leu Leu 
     450                455                460
Leu Ser Tyr Asn Gln Leu Thr Thr Leu Ser Ala Glu Val Leu Gly Pro 
 465                470                475                480
Leu Gln Arg Ala Phe Trp Leu Asp Ile Ser His Asn His Leu Glu Thr 
                 485                490                495
Leu Ala Glu Gly Leu Phe Ser Ser Leu Gly Arg Val Arg Tyr Leu Ser 
             500                505                510
Leu Arg Asn Asn Ser Leu Gln Thr Phe Ser Pro Gln Pro Gly Leu Glu 
         515                520                525
Arg Leu Trp Leu Asp Ala Asn Pro Trp Asp Cys Ser Cys Pro Leu Lys 
     530                535                540
Ala Leu Arg Asp Phe Ala Leu Gln Asn Pro Gly Val Val Pro Arg Phe 
 545                550                555                560
Val Gln Thr Val Cys Glu Gly Asp Asp Cys Gln Pro Val Tyr Thr Tyr 
                 565                570                575
Asn Asn Ile Thr Cys Ala Gly Pro Ala Asn Val Ser Gly Leu Asp Leu 
             580                585                590
Arg Asp Val Ser Glu Thr His Phe Val His Cys 
         595                600



<210> 7598
<211> 2125
<212> DNA
<213> Homo sapiens
<308> M86826
<400> 7598

ggcacagca  acgtaccct  cctcgctgc  tgcctgcgg  ctgccctgc  tgcaggatg  60
ccctgagga  aggaggcct  gccctggcg  tgctgctgc  gtcctgggt  gcactgggc  120
cccgcagcc  ggagggagc  gaccccgga  cgccggggg  agccgaggg  ccagcgtgc  180
cggccgcct  tgtctgcag  tacgatgac  acgcggatg  gctcagcgt  ttctgcagc  240
ccaggaacc  cacgcgcct  cctgacgga  tcccgggcg  cacccaagc  ctgtggctg  300
acggcaaca  cctctcgtc  gtccccccg  cagccttcc  gaacctctc  agcctgggc  360
tcctcaacc  gcagggcgg  cagctgggc  gcctggagc  acaggcgct  ctgggccta  420
agaacctgt  ccacctgca  ctggagcgg  accagctgc  cagcctggc  ctcggcacg  480
ttgcacaca  gcccgcgct  gcctcgctc  gcctcagca  caaccgtct  agcaggctg  540
aggacgggc  cttcgaggg  ctcggcagc  tctgggacc  caacctcgg  tggaatagc  600
tggcggtgc  ccccgatgc  gcgttccgc  gcctgggca  cctgcgcga  ctggtgctg  660
cgggcaaca  gctggccta  ctgcagccc  cgctcttca  cggcctggc  gagctccgg  720
agctggacc  gagcaggaa  gcgctgcgg  ccatcaagg  aaacgtgtt  gtgcagctg  780
cccggctcc  gaaactcta  ctggaccgc  acctcatcg  tgccgtggc  ccgggcgcc  840
tcctgggcc  gaaggcgct  cgatggctg  acctgtccc  caaccgcgt  gctggcctc  900
tggaggaca  gttccccgg  ctgctgggc  tgcgtgtgc  gcggctgtc  cacaacgcc  960
tcgccagcc  gcggccccg  accttcaag  acctgcact  cctggagga  ctgcagctg  1020
gccacaacc  catccggca  ctggctgag  gcagctttg  gggcctggg  cagcttgag  1080
tgctcacgc  agaccacaa  cagctccag  aggtcaagg  gggcgcttt  ctcggcctc  1140
ccaacgtgg  ggtcatgaa  ctctctggg  actgtctcc  gaaccttcc  gagcaggtg  1200
tccggggcc  gggcaagct  cacagcctg  acctggagg  cagctgcct  ggacgcatc  1260
gcccgcaca  cttcaccgg  ctctcgggg  tccgccgac  cttcctcaa  gacaacggc  1320
tcgtgggca  tgaggagca  agcctgtgg  ggctggcgg  gctgctgga  ctcgacctg  1380
cctccaacc  gctcacgca  ctgccccac  gcctcttcc  gggcctggg  aagctggag  1440
acctgctgc  ctcccgcaa  cgcctggca  agctgccgg  ggacgccct  ggccccctg  1500
agcgggcct  ctggctgga  gtctcgcac  accgcctgg  ggcattgcc  aacagcctc  1560
tggcaccac  ggggcggct  cgctacctc  gcctcagga  caactcact  cggaccttc  1620
cgccgcagc  cccgggcct  gagcgcctg  ggctggagg  taacccctg  gactgtggc  1680
gccctctca  ggcgctgcg  gacttcgcc  tgcagaacc  cagtgctgt  ccccgcttc  1740
tccaggcca  ctgtgaggg  gacgattgc  agccgcccg  gtacaccta  aacaacatc  1800
cctgtgcca  cccgcccga  gtcgtgggg  tcgacctgc  ggacctcag  gaggcccac  1860
ttgctccct  ctgaccagg  ccccggact  aagccccgg  ctcaggccc  cacctggct  1920
accttgtgc  ggggacagg  cctcagtgt  ctcaggggc  tgcccagtg  acttgctgg  1980
agacgcaag  gcctgatgg  gtggaaggc  tggcggccc  cccagctgt  atcaattaa  2040
ggcaaaggc  atcgaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2100
aaaaaaaaa  aaaaaaaaa  aaaaa  2125



<210> 7599
<211> 605
<212> PRT
<213> Homo sapiens
<308> P35858
<400> 7599

Met Ala Leu Arg Lys Gly Gly Leu Ala Leu Ala Leu Leu Leu Leu Ser 
  1               5                  10                  15
Trp Val Ala Leu Gly Pro Arg Ser Leu Glu Gly Ala Asp Pro Gly Thr 
             20                  25                  30
Pro Gly Glu Ala Glu Gly Pro Ala Cys Pro Ala Ala Cys Val Cys Ser 
         35                  40                  45
Tyr Asp Asp Asp Ala Asp Glu Leu Ser Val Phe Cys Ser Ser Arg Asn 
     50                  55                  60
Leu Thr Arg Leu Pro Asp Gly Val Pro Gly Gly Thr Gln Ala Leu Trp 
 65                  70                  75                  80
Leu Asp Gly Asn Asn Leu Ser Ser Val Pro Pro Ala Ala Phe Gln Asn 
                 85                  90                  95
Leu Ser Ser Leu Gly Phe Leu Asn Leu Gln Gly Gly Gln Leu Gly Ser 
             100                105                110
Leu Glu Pro Gln Ala Leu Leu Gly Leu Glu Asn Leu Cys His Leu His 
         115                120                125
Leu Glu Arg Asn Gln Leu Arg Ser Leu Ala Leu Gly Thr Phe Ala His 
     130                135                140
Thr Pro Ala Leu Ala Ser Leu Gly Leu Ser Asn Asn Arg Leu Ser Arg 
 145                150                155                160
Leu Glu Asp Gly Leu Phe Glu Gly Leu Gly Ser Leu Trp Asp Leu Asn 
                 165                170                175
Leu Gly Trp Asn Ser Leu Ala Val Leu Pro Asp Ala Ala Phe Arg Gly 
             180                185                190
Leu Gly Ser Leu Arg Glu Leu Val Leu Ala Gly Asn Arg Leu Ala Tyr 
         195                200                205
Leu Gln Pro Ala Leu Phe Ser Gly Leu Ala Glu Leu Arg Glu Leu Asp 
     210                215                220
Leu Ser Arg Asn Ala Leu Arg Ala Ile Lys Ala Asn Val Phe Val Gln 
 225                230                235                240
Leu Pro Arg Leu Gln Lys Leu Tyr Leu Asp Arg Asn Leu Ile Ala Ala 
                 245                250                255
Val Ala Pro Gly Ala Phe Leu Gly Leu Lys Ala Leu Arg Trp Leu Asp 
             260                265                270
Leu Ser His Asn Arg Val Ala Gly Leu Leu Glu Asp Thr Phe Pro Gly 
         275                280                285
Leu Leu Gly Leu Arg Val Leu Arg Leu Ser His Asn Ala Ile Ala Ser 
     290                295                300
Leu Arg Pro Arg Thr Phe Lys Asp Leu His Phe Leu Glu Glu Leu Gln 
 305                310                315                320
Leu Gly His Asn Arg Ile Arg Gln Leu Ala Glu Arg Ser Phe Glu Gly 
                 325                330                335
Leu Gly Gln Leu Glu Val Leu Thr Leu Asp His Asn Gln Leu Gln Glu 
             340                345                350
Val Lys Ala Gly Ala Phe Leu Gly Leu Thr Asn Val Ala Val Met Asn 
         355                360                365
Leu Ser Gly Asn Cys Leu Arg Asn Leu Pro Glu Gln Val Phe Arg Gly 
     370                375                380
Leu Gly Lys Leu His Ser Leu His Leu Glu Gly Ser Cys Leu Gly Arg 
 385                390                395                400
Ile Arg Pro His Thr Phe Thr Gly Leu Ser Gly Leu Arg Arg Leu Phe 
                 405                410                415
Leu Lys Asp Asn Gly Leu Val Gly Ile Glu Glu Gln Ser Leu Trp Gly 
             420                425                430
Leu Ala Glu Leu Leu Glu Leu Asp Leu Thr Ser Asn Gln Leu Thr His 
         435                440                445
Leu Pro His Arg Leu Phe Gln Gly Leu Gly Lys Leu Glu Tyr Leu Leu 
     450                455                460
Leu Ser Arg Asn Arg Leu Ala Glu Leu Pro Ala Asp Ala Leu Gly Pro 
 465                470                475                480
Leu Gln Arg Ala Phe Trp Leu Asp Val Ser His Asn Arg Leu Glu Ala 
                 485                490                495
Leu Pro Asn Ser Leu Leu Ala Pro Leu Gly Arg Leu Arg Tyr Leu Ser 
             500                505                510
Leu Arg Asn Asn Ser Leu Arg Thr Phe Thr Pro Gln Pro Pro Gly Leu 
         515                520                525
Glu Arg Leu Trp Leu Glu Gly Asn Pro Trp Asp Cys Gly Cys Pro Leu 
     530                535                540
Lys Ala Leu Arg Asp Phe Ala Leu Gln Asn Pro Ser Ala Val Pro Arg 
 545                550                555                560
Phe Val Gln Ala Ile Cys Glu Gly Asp Asp Cys Gln Pro Pro Ala Tyr 
                 565                570                575
Thr Tyr Asn Asn Ile Thr Cys Ala Ser Pro Pro Glu Val Val Gly Leu 
             580                585                590
Asp Leu Arg Asp Leu Ser Glu Ala His Phe Ala Pro Cys 
         595                600                605



<210> 7600
<211> 2141
<212> DNA
<213> Rattus norvegicus
<308> S47609
<400> 7600

gctgcagct  tggaccgag  gctggccca  gcctgcatc  ctgctgagc  tgcccaagt  60
tggctgctc  caccatggg  tcctcggtg  acatcacgg  ggagctggc  atcgctgtg  120
tggccatcc  gggcaacgt  ctcgtgtgc  gggccgtgt  gatcaacag  aacctgcag  180
acgtcacca  cttctttgt  gtatcgctg  cggcggctg  cattgcagt  ggtgtgctc  240
ccatcccct  cgctatcac  atcagcacc  gcttctgcg  cgcctgcca  ggctgcctc  300
tcttcgcct  ttttgtcct  gtcctcacg  agagttcca  ctttagcct  ttggctatc  360
ccatcgacc  ctacatcgc  atccgaatt  cactccggt  caatggctt  gtgacaggt  420
tgagggcga  gggcatcat  gcaatttgc  gggtgctgt  gtttgccat  ggcctgacc  480
ccatgctgg  ctggaacaa  tgcagtcag  aagacggga  ctccacgaa  acctgcggc  540
agggccggg  gacctgtct  ttcgaggac  tggtgccca  gaattacat  gtttactac  600
acttctttg  gttcgtgtt  ctgcccctt  tgctcatgc  ggccatcta  ctacggatt  660
ttctggcgg  ccggagaca  ctgaagcag  tggagagcc  gcccctgcc  ggggagcgg  720
ctcggtcca  gctgcagaa  gaggtccac  ctgccaagt  cctggccat  atcgtcggg  780
tctttgctc  gtgctggtt  ccgctgcac  tcatcaact  tttcacctt  ttctgctcc  840
cgtgccggc  cgcccctcc  tggctcatg  acctggcca  catcctctc  cacagcaac  900
ccgtcgtca  ccccttcat  tacgcctac  ggatccggg  gttccgcca  accttccgg  960
agatcatcc  aacccacgt  ctgaggcgg  aggaaccct  ccaggcagg  ggttccagt  1020
cctgggccc  ggcagctca  agcactgag  gagagcagg  tagcctccg  cttaatggc  1080
accccctgg  ggtatgggc  aacggcagt  ccacccatt  cggacggcg  cccaatggc  1140
acactctgg  gctgggggg  ggagggagt  cccaaggct  tcctcggga  gtggagctt  1200
ctacccagg  gcgccagga  ggccaagag  accctggcc  aaggggtca  ctggtccag  1260
ctagagtag  agcttcctc  tggtcttca  agtttgccc  ttcctgagg  aaagacatt  1320
taatatttt  ggttggctg  accaatctc  ctaagggaa  agaaaccca  tgggcgcgt  1380
gctcccact  tgaactaca  agagggggc  tgaagttgg  gcagcatga  gcccagtaa  1440
aaaggcctg  ggtggagga  gcgatgctt  tgcttcgtg  tacggggcc  tgtgttagg  1500
cagggctgc  gtagcatct  caaaggcag  gcccagttc  cctgctcca  aagcgtcca  1560
aaagctgtc  tgtctctct  gagcggttg  ggcttagag  actggcctg  cccgatgct  1620
gaatatagg  gcttcagac  tcctgctgt  gtacactac  ctccccaga  tgtctaggg  1680
tcagggagc  gctggccta  aagtggcac  tggctattt  tttttcaag  agataaaaa  1740
gtgaggaaa  ccattctat  ttattgact  cccccctcc  ctgcctgct  ggtctgtgg  1800
cgatcctgc  gggaacccc  ccaaccaag  aattgaagg  ggtcttctt  ggctagccc  1860
agctaccat  cacttagtc  cagggctat  tctgaccaa  aaagctggc  tggaagaca  1920
caactatga  gggaaggat  ccagagcat  ggctcaggt  ccatgagag  gattagaga  1980
gtcaagcca  ggacctgaa  ctgggtagt  cagcgctac  ctgtctgag  ccctgacta  2040
tgcctttcc  tccagaggg  cttgtttgt  tgtttgttt  tggtttttt  tttccctga  2100
gtaaaataa  atgagccac  ctgtgtttt  aatttaaaa  a  2141



<210> 7601
<211> 410
<212> PRT
<213> Rattus norvegicus
<308> AAA11888
<400> 7601

Met Gly Ser Ser Val Tyr Ile Thr Val Glu Leu Ala Ile Ala Val Leu 
  1               5                  10                  15
Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp Ile Asn Ser 
             20                  25                  30
Asn Leu Gln Asn Val Thr Asn Phe Phe Val Val Ser Leu Ala Ala Ala 
         35                  40                  45
Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile Thr Ile Ser 
     50                  55                  60
Thr Gly Phe Cys Ala Ala Cys His Gly Cys Leu Phe Phe Ala Cys Phe 
 65                  70                  75                  80
Val Leu Val Leu Thr Gln Ser Ser Ile Phe Ser Leu Leu Ala Ile Ala 
                 85                  90                  95
Ile Asp Arg Tyr Ile Ala Ile Arg Ile Pro Leu Arg Tyr Asn Gly Leu 
             100                105                110
Val Thr Gly Val Arg Ala Lys Gly Ile Ile Ala Ile Cys Trp Val Leu 
         115                120                125
Ser Phe Ala Ile Gly Leu Thr Pro Met Leu Gly Trp Asn Asn Cys Ser 
     130                135                140
Gln Lys Asp Gly Asn Ser Thr Lys Thr Cys Gly Glu Gly Arg Val Thr 
 145                150                155                160
Cys Leu Phe Glu Asp Val Val Pro Met Asn Tyr Met Val Tyr Tyr Asn 
                 165                170                175
Phe Phe Ala Phe Val Leu Leu Pro Leu Leu Leu Met Leu Ala Ile Tyr 
             180                185                190
Leu Arg Ile Phe Leu Ala Ala Arg Arg Gln Leu Lys Gln Met Glu Ser 
         195                200                205
Gln Pro Leu Pro Gly Glu Arg Thr Arg Ser Thr Leu Gln Lys Glu Val 
     210                215                220
His Ala Ala Lys Ser Leu Ala Ile Ile Val Gly Leu Phe Ala Leu Cys 
 225                230                235                240
Trp Leu Pro Leu His Ile Ile Asn Cys Phe Thr Phe Phe Cys Ser Thr 
                 245                250                255
Cys Arg His Ala Pro Pro Trp Leu Met Tyr Leu Ala Ile Ile Leu Ser 
             260                265                270
His Ser Asn Ser Val Val Asn Pro Phe Ile Tyr Ala Tyr Arg Ile Arg 
         275                280                285
Glu Phe Arg Gln Thr Phe Arg Lys Ile Ile Arg Thr His Val Leu Arg 
     290                295                300
Arg Gln Glu Pro Phe Gln Ala Gly Gly Ser Ser Ala Trp Ala Leu Ala 
 305                310                315                320
Ala His Ser Thr Glu Gly Glu Gln Val Ser Leu Arg Leu Asn Gly His 
                 325                330                335
Pro Leu Gly Val Trp Ala Asn Gly Ser Ala Thr His Ser Gly Arg Arg 
             340                345                350
Pro Asn Gly Tyr Thr Leu Gly Leu Gly Gly Gly Gly Ser Ala Gln Gly 
         355                360                365
Ser Pro Arg Asp Val Glu Leu Pro Thr Gln Glu Arg Gln Glu Gly Gln 
     370                375                380
Glu His Pro Gly Leu Arg Gly His Leu Val Gln Ala Arg Val Gly Ala 
 385                390                395                400
Ser Ser Trp Ser Ser Glu Phe Ala Pro Ser 
                 405                410



<210> 7602
<211> 2572
<212> DNA
<213> Homo sapiens
<308> S46950
<400> 7602

aattttcag  tgttctttg  tcaataata  cttttttat  accaagata  ctctctaag  60
ttttgacat  ttcctcatt  gttttgata  aagttttct  attttctta  aaaaataag  120
tactaaaag  catatatca  tgtatatct  caaaatatt  cttaaaact  ggacttgta  180
ttaaatgtt  tttcttctt  aagacaatt  gcaggtgcc  tcaggaacc  tgaagctgg  240
ctgagccat  atgctgctg  cagaacccc  gcagagggc  tggtttcag  agactcaga  300
tcctctgtg  aaaagccct  ggagagcgc  ccagcaggg  tgcacttgg  tcctgtgag  360
aaggggctc  ggggtctgg  cccctccgc  tgggccggg  tgggagcca  gcgggcggc  420
gggctgcag  aatggaccg  gagctggcc  agcccgcgt  cgtgctgag  ctgcctgtc  480
tctgtggcc  tgcccatca  gggctcctc  gtgtacatc  cggtggagc  ggccattgc  540
gtgctggcc  tcctgggca  tgtgctggt  tgctgggcc  tgtggctca  cagcaacct  600
cagaacgtc  ccaactact  tgtggtgtc  ctggcggcg  ccgacatcg  agtgggtgt  660
ctcgccatc  cctttgcca  caccatcag  accgggttc  gcgctgcct  ccacggctg  720
ctcttcatt  cctgcttcg  cctggtcct  acgcagagc  ccatcttca  tctcctggc  780
atcgccatt  accgctaca  tgccatccg  atcccgctc  ggtacaatg  cttggtgac  840
ggcacgagg  ctaagggca  cattgccat  tgctgggtg  tgtcgtttg  catcggcct  900
actcccatg  taggttgga  caactgcgg  cagccaaag  agggcaaga  ccactccca  960
ggctgcggg  agggccaag  ggcctgtct  tttgaggat  tggtcccca  gaactacat  1020
gtgtacttc  acttctttg  ctgtgtgct  gtgcccctg  tgctcatgc  gggtgtcta  1080
ttgcggatc  tcctggcgg  gcgacgaca  ctgaagcag  tggagagcc  gcctctgcc  1140
ggggagcgg  cacggtcca  actgcagaa  gaggtccat  ctgccaagt  actggccat  1200
attgtgggg  tctttgccc  ctgctggct  cccctacac  tcatcaact  cttcacttt  1260
ttctgcccc  actgcagcc  cgcccctct  tggctcatg  acctggcca  cgtcctctc  1320
cacaccaat  cggttgtga  tcccttcat  tacgcctac  gtatccgcg  gttccgcca  1380
accttccgc  agatcattc  cagccacgt  ctgaggcag  aagaacctt  caaggcagc  1440
ggcaccagt  cccgggtct  ggcagctca  ggcagtgac  gagagcagg  cagcctccg  1500
ctcaacggc  acccgccag  agtgtgggc  aacggcagt  ctccccacc  tgagcggag  1560
cccaatggc  acgccctgg  gctggtgag  ggagggagt  cccaagagt  ccaggggaa  1620
acgggcctc  cagacgtgg  gctccttag  catgagctc  agagagtgt  cccagagcc  1680
cctggccta  atgaccccc  ggcccagga  ggagcagga  tgtcctgat  attcatgga  1740
tttgcccct  cctaaggga  ggagatctt  atctttctg  ttggcttga  cagtcacgt  1800
gggagaaga  agagagtgc  aggagaccc  gagggcagc  ggttcctac  ttggactga  1860
agaagggag  cccaggctg  agcagcatg  ggcccagca  gaagggctt  ggttctgag  1920
aagcagatg  ttcatgctg  gaggccttg  accaggtgg  ggccacagc  ccagcagca  1980
ctttgctgg  cagggccca  ccctccact  cagaagcat  tggaagcac  accttgtct  2040
cacagagca  cttgggcac  gcagactgg  ctggccctg  gactgggga  tggctccaa  2100
agcctcctg  cacccacac  ccactctcc  tagactctc  tagggttca  gagctgctg  2160
gcccagagg  gacatttga  tttttttcc  ggaaaaatg  aagtgtgag  aaacccttt  2220
tattttatt  cctttcact  tctggctgc  gggtctgcc  tcggtcctg  tgctaacct  2280
gcaccagag  ctctgcccg  ggagcctca  gcagtcctc  cctgctgtc  cagctgcca  2340
ccacttctc  gtcccaggg  catctcttg  agtgacaaa  ctgggatca  ggacaggga  2400
ttgtaacag  gcagtgcca  agcatgggc  caggtccca  gggagaggt  ggggctggc  2460
ggccactgg  atgtgctga  tagcgcaga  ctacccagt  agaggcctt  tctaactgc  2520
tttccttct  aagggaatg  ttttttctg  gataaaata  aaacgagcc  ca  2572



<210> 7603
<211> 412
<212> PRT
<213> Homo sapiens
<308> P29274
<400> 7603

Met Pro Ile Met Gly Ser Ser Val Tyr Ile Thr Val Glu Leu Ala Ile 
  1               5                  10                  15
Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp 
             20                  25                  30
Leu Asn Ser Asn Leu Gln Asn Val Thr Asn Tyr Phe Val Val Ser Leu 
         35                  40                  45
Ala Ala Ala Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile 
     50                  55                  60
Thr Ile Ser Thr Gly Phe Cys Ala Ala Cys His Gly Cys Leu Phe Ile 
 65                  70                  75                  80
Ala Cys Phe Val Leu Val Leu Thr Gln Ser Ser Ile Phe Ser Leu Leu 
                 85                  90                  95
Ala Ile Ala Ile Asp Arg Tyr Ile Ala Ile Arg Ile Pro Leu Arg Tyr 
             100                105                110
Asn Gly Leu Val Thr Gly Thr Arg Ala Lys Gly Ile Ile Ala Ile Cys 
         115                120                125
Trp Val Leu Ser Phe Ala Ile Gly Leu Thr Pro Met Leu Gly Trp Asn 
     130                135                140
Asn Cys Gly Gln Pro Lys Glu Gly Lys Asn His Ser Gln Gly Cys Gly 
 145                150                155                160
Glu Gly Gln Val Ala Cys Leu Phe Glu Asp Val Val Pro Met Asn Tyr 
                 165                170                175
Met Val Tyr Phe Asn Phe Phe Ala Cys Val Leu Val Pro Leu Leu Leu 
             180                185                190
Met Leu Gly Val Tyr Leu Arg Ile Phe Leu Ala Ala Arg Arg Gln Leu 
         195                200                205
Lys Gln Met Glu Ser Gln Pro Leu Pro Gly Glu Arg Ala Arg Ser Thr 
     210                215                220
Leu Gln Lys Glu Val His Ala Ala Lys Ser Leu Ala Ile Ile Val Gly 
 225                230                235                240
Leu Phe Ala Leu Cys Trp Leu Pro Leu His Ile Ile Asn Cys Phe Thr 
                 245                250                255
Phe Phe Cys Pro Asp Cys Ser His Ala Pro Leu Trp Leu Met Tyr Leu 
             260                265                270
Ala Ile Val Leu Ser His Thr Asn Ser Val Val Asn Pro Phe Ile Tyr 
         275                280                285
Ala Tyr Arg Ile Arg Glu Phe Arg Gln Thr Phe Arg Lys Ile Ile Arg 
     290                295                300
Ser His Val Leu Arg Gln Gln Glu Pro Phe Lys Ala Ala Gly Thr Ser 
 305                310                315                320
Ala Arg Val Leu Ala Ala His Gly Ser Asp Gly Glu Gln Val Ser Leu 
                 325                330                335
Arg Leu Asn Gly His Pro Pro Gly Val Trp Ala Asn Gly Ser Ala Pro 
             340                345                350
His Pro Glu Arg Arg Pro Asn Gly Tyr Ala Leu Gly Leu Val Ser Gly 
         355                360                365
Gly Ser Ala Gln Glu Ser Gln Gly Asn Thr Gly Leu Pro Asp Val Glu 
     370                375                380
Leu Leu Ser His Glu Leu Lys Gly Val Cys Pro Glu Pro Pro Gly Leu 
 385                390                395                400
Asp Asp Pro Leu Ala Gln Asp Gly Ala Gly Val Ser 
                 405                410



<210> 7604
<211> 2066
<212> DNA
<213> Rattus norvegicus
<308> S50879
<400> 7604

atgaggcct  cctggtatc  cctgcatac  ccctccctg  cttctccac  cctcttcct  60
ctcctctcc  tcctgggag  aggggcaag  gctgagggc  gggaagacc  tcagctgct  120
gtgagggtt  gagggggcc  gctgagggg  atccgcctg  aggcccctg  aggcccagt  180
tcagctttt  tgggcatcc  ctttgcaga  ccacctgtg  gctcacgta  atttatgcc  240
ccagagccc  agcgcccct  gtcaggaat  ttggatgct  ccaccttcc  aaatgtctg  300
taccaatac  tggacaccc  gtaccctgg  tttgagggt  ccgagatgt  gaaccccaa  360
cgagagctg  gtgaagact  cctttatct  aatgtgtgg  caccatacc  caggcctac  420
tctcccaca  ctgtcctca  ctggatcta  gggggtggt  tctacagtg  agcatcctc  480
ttggacgtg  atgacggcc  tttcctggc  caggttgag  gaaccgtgt  ggtatctat  540
aactaccga  tgggaacct  tggcttctt  gctctacca  gaagcagag  agcccctgg  600
aatgtaggc  tgctggatc  acggcttgc  ttgcaatgg  tacaagaaa  tatcgcagc  660
tttggggga  acccaatgt  agtgactct  tttggggag  gtgcaggtg  agcctcagt  720
ggcatgcac  ttctgtccc  gcccagcag  agcctcttc  acagggctg  cctgcagag  780
ggcacaccc  atgggccct  ggccactgt  agtgcggga  aggccaggc  cagggccac  840
ctgctggcc  gccttgtgg  ctgtccccc  ggtggcgct  gtggcaatg  caccgagct  900
atatcctgc  tgaggacaa  gcccgctca  gacctggtg  accacgagt  gcatgtgct  960
cctcaagaa  gtatcttcc  gttttcctt  gtgcctgtg  tggacgggg  tttcctcag  1020
gacacgccg  acgctctca  caatactgg  gattttcaa  acctgcagg  gctggtggg  1080
gtggtgaag  acgagggct  ctactttct  gtttacggg  tcccaggct  cagcaaaga  1140
aatgaatct  tcatcagcc  ggcccagtt  ctggctggg  tgcggatcg  tgtacccca  1200
gcgagtgac  tggcggccg  ggctgtggt  ctgcattat  cagactggc  gcaccctga  1260
gaccctgcc  acctgagag  tgccatgag  gcggtggta  gcgaccaca  cgttgtgtg  1320
cctgtggcc  agctggctg  gcgactggc  gcccaaggg  ctcgggtct  tgcctacat  1380
tttgaacac  gtgcctcca  attgacttg  cccctctgg  tgggggtgc  ccatggcta  1440
gaaatcgag  tcatctttg  gctccccct  gatccctca  tgaactaca  cgtggagga  1500
agaatcttt  ctcagcgac  tatgcaata  tggaccaat  ttgcccgca  aggggaccc  1560
aatgaccct  gagactcta  gtctccacg  tggccaccg  acaccactg  cgcgcagca  1620
tacgtgagc  tgaacctga  gcctttgga  gtgcggcgg  gactgcgcg  ccagacctg  1680
gccttctgg  atcgttttc  ccccaaatt  ctcagcgcc  cagacacgc  ggacgaggc  1740
gagcgccag  ggaaggccg  gttccaccg  tggagctcc  acatggtgc  ctggaagaa  1800
cagttcgac  actatagca  gcaggaacg  tgctcagac  tgtgacccc  tggggaccc  1860
ggtcctgcc  tcctgcccg  gcccctgat  gtatataca  tatttattt  agggctggg  1920
tataataca  ccgagcccc  aggccctgt  cacccctcc  cgacttcct  ccactaggg  1980
atcctcatc  tctgcatgt  ttaaactga  ctcccctcc  cgcggtgcc  tgccccctc  2040
gggccgcca  taaactgtt  cagctc  2066



<210> 7605
<211> 614
<212> PRT
<213> Rattus norvegicus
<308> AAB24586
<400> 7605

Met Arg Pro Pro Trp Tyr Pro Leu His Thr Pro Ser Leu Ala Ser Pro 
  1               5                  10                  15
Leu Leu Phe Leu Leu Leu Ser Leu Leu Gly Gly Gly Ala Arg Ala Glu 
             20                  25                  30
Gly Arg Glu Asp Pro Gln Leu Leu Val Arg Val Arg Gly Gly Gln Leu 
         35                  40                  45
Arg Gly Ile Arg Leu Lys Ala Pro Gly Gly Pro Val Ser Ala Phe Leu 
     50                  55                  60
Gly Ile Pro Phe Ala Glu Pro Pro Val Gly Ser Arg Arg Phe Met Pro 
 65                  70                  75                  80
Pro Glu Pro Lys Arg Pro Trp Ser Gly Ile Leu Asp Ala Thr Thr Phe 
                 85                  90                  95
Gln Asn Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
             100                105                110
Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
         115                120                125
Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
     130                135                140
Val Leu Ile Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
 145                150                155                160
Leu Asp Val Tyr Asp Gly Arg Phe Leu Ala Gln Val Glu Gly Thr Val 
                 165                170                175
Leu Val Ser Met Asn Tyr Arg Val Gly Thr Phe Gly Phe Leu Ala Leu 
             180                185                190
Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
         195                200                205
Leu Ala Leu Gln Trp Val Gln Glu Asn Ile Ala Ala Phe Gly Gly Asp 
     210                215                220
Pro Met Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
 225                230                235                240
Gly Met His Ile Leu Ser Leu Pro Ser Arg Ser Leu Phe His Arg Ala 
                 245                250                255
Val Leu Gln Ser Gly Thr Pro Asn Gly Pro Trp Ala Thr Val Ser Ala 
             260                265                270
Gly Glu Ala Arg Arg Arg Ala Thr Leu Leu Ala Arg Leu Val Gly Cys 
         275                280                285
Pro Pro Gly Gly Ala Gly Gly Asn Asp Thr Glu Leu Ile Ser Cys Leu 
     290                295                300
Arg Thr Arg Pro Ala Gln Asp Leu Val Asp His Glu Trp His Val Leu 
 305                310                315                320
Pro Gln Glu Ser Ile Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                 325                330                335
Asp Phe Leu Ser Asp Thr Pro Asp Ala Leu Ile Asn Thr Gly Asp Phe 
             340                345                350
Gln Asp Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
         355                360                365
Phe Leu Val Tyr Gly Val Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
     370                375                380
Ile Ser Arg Ala Gln Phe Leu Ala Gly Val Arg Ile Gly Val Pro Gln 
 385                390                395                400
Ala Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                 405                410                415
Leu His Pro Glu Asp Pro Ala His Leu Arg Asp Ala Met Ser Ala Val 
             420                425                430
Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
         435                440                445
Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Ile Phe Glu His Arg 
     450                455                460
Ala Ser Thr Leu Thr Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
 465                470                475                480
Glu Ile Glu Phe Ile Phe Gly Leu Pro Leu Asp Pro Ser Leu Asn Tyr 
                 485                490                495
Thr Val Glu Glu Arg Ile Phe Ala Gln Arg Leu Met Gln Tyr Trp Thr 
             500                505                510
Asn Phe Ala Arg Thr Gly Asp Pro Asn Asp Pro Arg Asp Ser Lys Ser 
         515                520                525
Pro Arg Trp Pro Pro Tyr Thr Thr Ala Ala Gln Gln Tyr Val Ser Leu 
     530                535                540
Asn Leu Lys Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Thr Cys 
 545                550                555                560
Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Asp Thr 
                 565                570                575
Leu Asp Glu Ala Glu Arg Gln Trp Lys Ala Glu Phe His Arg Trp Ser 
             580                585                590
Ser Tyr Met Val His Trp Lys Asn Gln Phe Asp His Tyr Ser Lys Gln 
         595                600                605
Glu Arg Cys Ser Asp Leu 
     610



<210> 7606
<211> 2156
<212> DNA
<213> Homo sapiens
<308> NM_000665
<400> 7606

cagcctgcg  cggggaaca  cggccgcct  cagctcccg  cgcggcccg  cccggcccg  60
ctcggccgc  tcagacgcc  cctgccctg  agccatgag  cccccgcag  gtctgctgc  120
cacgccttc  ctggcttcc  cactccttc  cctcctcct  tggctcctg  gtggaggag  180
gggggctga  ggccgggag  atgcagagc  gctggtgac  gtgcgtggg  gccggctgc  240
gggcattcg  ctgaagacc  ccgggggcc  tgtctctgc  ttcctgggc  tcccctttg  300
ggagccacc  atgggaccc  gtcgctttc  gccaccgga  cccaagcag  cttggtcag  360
ggtggtaga  gctacaacc  tccagagtg  ctgctacca  tatgtggac  ccctatacc  420
aggttttga  ggcaccgag  tgtggaacc  caaccgtga  ctgagcgag  actgcctgt  480
cctcaacgt  tggacacca  acccccggc  tacatcccc  acccctgtc  tcgtctgga  540
ctatggggg  ggcttctac  gtggggcct  ctccttgga  gtgtacgat  gccgcttct  600
ggtacaggc  gagaggact  tgctggtgt  catgaacta  cgggtggga  cctttggct  660
cctggccct  ccggggagc  gagaggccc  gggcaatgt  ggtctcctg  atcagaggc  720
ggccctgca  tgggtgcag  agaacgtgg  agccttcgg  ggtgacccg  catcagtga  780
gctgtttgg  gagagcgcg  gagccgcct  ggtgggcat  cacctgctg  ccccgccca  840
ccggggcct  ttccacagg  ccgtgctgc  gagcggtgc  cccaatgga  cctgggcca  900
ggtgggcat  ggagaggcc  gtcgcaggg  cacgcagct  gcccacctt  tgggctgtc  960
tccaggcgg  actggtggg  atgacacag  gctggtagc  tgccttcgg  cacgaccag  1020
gcaggtcct  gtgaaccac  aatggcacg  gctgcctca  gaaagcgtc  tccggttct  1080
cttcgtgcc  gtggtagat  gagacttcc  cagtgacac  ccagaggcc  tcatcaacg  1140
gggagactt  cacggcctg  aggtgctgg  gggtgtggt  aaggatgag  gctcgtatt  1200
tctggttta  ggggcccca  gcttcagca  agacaacga  tctctcatc  gccgggccg  1260
gttcctggc  ggggtgcgg  tcggggttc  ccaggtaag  gacctggca  ccgaggctg  1320
ggtcctgca  tacacagac  ggctgcatc  cgaggaccc  gcacgcctg  gggaggccc  1380
gagcgatgt  gtgggcgac  acaatgtcg  gtgccccgt  gcccagctg  ctgggcgac  1440
ggctgccca  ggtgcccgg  tctacgcct  cgtctttga  caccgtgct  ccacgctct  1500
ctggcccct  tggatgggg  tgccccacg  ctacgagat  gagttcatc  ttgggatcc  1560
cctggaccc  tctcgaaac  acacggcag  ggagaaaat  ttcgcccag  gactgatgc  1620
atactgggc  aactttgcc  gcacagggg  tcccaatga  ccccgagac  ccaaggccc  1680
acaatggcc  ccgtacacg  cgggggctc  gcagtacgt  agtctggac  tgcggccgc  1740
ggaggtgcg  cgggggctg  gcgcccagg  ctgcgcctt  tggaaccgc  tcctcccca  1800
attgctcag  gccaccgac  cgctcgacg  ggcggagcg  cagtggaag  ccgagttcc  1860
ccgctggag  tcctacatg  tgcactgga  gaaccagtt  gaccactac  gcaagcagg  1920
tcgctgctc  gacctgtga  cccggcggg  cccccatgt  ctccgctcc  cccggcccc  1980
tagctgtat  tactattta  ttcagggct  ggctataac  cagacgagc  ccagactct  2040
cccatcccc  ccccacccc  acgtccccc  gggctcccg  tcctctggc  tgtcttcag  2100
ctgagctcc  ccccgcgtg  cttcgccct  tggctgcaa  taaactgtt  caggcc  2156



<210> 7607
<211> 614
<212> PRT
<213> Homo sapiens
<308> P22303
<400> 7607

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
  1               5                  10                  15
Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
             20                  25                  30
Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
         35                  40                  45
Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
     50                  55                  60
Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
 65                  70                  75                  80
Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                 85                  90                  95
Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
             100                105                110
Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
         115                120                125
Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
     130                135                140
Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
 145                150                155                160
Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                 165                170                175
Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
             180                185                190
Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
         195                200                205
Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
     210                215                220
Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
 225                230                235                240
Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                 245                250                255
Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
             260                265                270
Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
         275                280                285
Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
     290                295                300
Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
 305                310                315                320
Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                 325                330                335
Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
             340                345                350
His Gly Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
         355                360                365
Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
     370                375                380
Ile Ser Arg Ala Glu Phe Leu Ala Gly Val Arg Val Gly Val Pro Gln 
 385                390                395                400
Val Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                 405                410                415
Leu His Pro Glu Asp Pro Ala Arg Leu Arg Glu Ala Leu Ser Asp Val 
             420                425                430
Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
         435                440                445
Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Val Phe Glu His Arg 
     450                455                460
Ala Ser Thr Leu Ser Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
 465                470                475                480
Glu Ile Glu Phe Ile Phe Gly Ile Pro Leu Asp Pro Ser Arg Asn Tyr 
                 485                490                495
Thr Ala Glu Glu Lys Ile Phe Ala Gln Arg Leu Met Arg Tyr Trp Ala 
             500                505                510
Asn Phe Ala Arg Thr Gly Asp Pro Asn Glu Pro Arg Asp Pro Lys Ala 
         515                520                525
Pro Gln Trp Pro Pro Tyr Thr Ala Gly Ala Gln Gln Tyr Val Ser Leu 
     530                535                540
Asp Leu Arg Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Ala Cys 
 545                550                555                560
Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Asp Thr 
                 565                570                575
Leu Asp Glu Ala Glu Arg Gln Trp Lys Ala Glu Phe His Arg Trp Ser 
             580                585                590
Ser Tyr Met Val His Trp Lys Asn Gln Phe Asp His Tyr Ser Lys Gln 
         595                600                605
Asp Arg Cys Ser Asp Leu 
     610



<210> 7608
<211> 2066
<212> DNA
<213> Rattus norvegicus
<308> S50879
<400> 7608

atgaggcct  cctggtatc  cctgcatac  ccctccctg  cttctccac  cctcttcct  60
ctcctctcc  tcctgggag  aggggcaag  gctgagggc  gggaagacc  tcagctgct  120
gtgagggtt  gagggggcc  gctgagggg  atccgcctg  aggcccctg  aggcccagt  180
tcagctttt  tgggcatcc  ctttgcaga  ccacctgtg  gctcacgta  atttatgcc  240
ccagagccc  agcgcccct  gtcaggaat  ttggatgct  ccaccttcc  aaatgtctg  300
taccaatac  tggacaccc  gtaccctgg  tttgagggt  ccgagatgt  gaaccccaa  360
cgagagctg  gtgaagact  cctttatct  aatgtgtgg  caccatacc  caggcctac  420
tctcccaca  ctgtcctca  ctggatcta  gggggtggt  tctacagtg  agcatcctc  480
ttggacgtg  atgacggcc  tttcctggc  caggttgag  gaaccgtgt  ggtatctat  540
aactaccga  tgggaacct  tggcttctt  gctctacca  gaagcagag  agcccctgg  600
aatgtaggc  tgctggatc  acggcttgc  ttgcaatgg  tacaagaaa  tatcgcagc  660
tttggggga  acccaatgt  agtgactct  tttggggag  gtgcaggtg  agcctcagt  720
ggcatgcac  ttctgtccc  gcccagcag  agcctcttc  acagggctg  cctgcagag  780
ggcacaccc  atgggccct  ggccactgt  agtgcggga  aggccaggc  cagggccac  840
ctgctggcc  gccttgtgg  ctgtccccc  ggtggcgct  gtggcaatg  caccgagct  900
atatcctgc  tgaggacaa  gcccgctca  gacctggtg  accacgagt  gcatgtgct  960
cctcaagaa  gtatcttcc  gttttcctt  gtgcctgtg  tggacgggg  tttcctcag  1020
gacacgccg  acgctctca  caatactgg  gattttcaa  acctgcagg  gctggtggg  1080
gtggtgaag  acgagggct  ctactttct  gtttacggg  tcccaggct  cagcaaaga  1140
aatgaatct  tcatcagcc  ggcccagtt  ctggctggg  tgcggatcg  tgtacccca  1200
gcgagtgac  tggcggccg  ggctgtggt  ctgcattat  cagactggc  gcaccctga  1260
gaccctgcc  acctgagag  tgccatgag  gcggtggta  gcgaccaca  cgttgtgtg  1320
cctgtggcc  agctggctg  gcgactggc  gcccaaggg  ctcgggtct  tgcctacat  1380
tttgaacac  gtgcctcca  attgacttg  cccctctgg  tgggggtgc  ccatggcta  1440
gaaatcgag  tcatctttg  gctccccct  gatccctca  tgaactaca  cgtggagga  1500
agaatcttt  ctcagcgac  tatgcaata  tggaccaat  ttgcccgca  aggggaccc  1560
aatgaccct  gagactcta  gtctccacg  tggccaccg  acaccactg  cgcgcagca  1620
tacgtgagc  tgaacctga  gcctttgga  gtgcggcgg  gactgcgcg  ccagacctg  1680
gccttctgg  atcgttttc  ccccaaatt  ctcagcgcc  cagacacgc  ggacgaggc  1740
gagcgccag  ggaaggccg  gttccaccg  tggagctcc  acatggtgc  ctggaagaa  1800
cagttcgac  actatagca  gcaggaacg  tgctcagac  tgtgacccc  tggggaccc  1860
ggtcctgcc  tcctgcccg  gcccctgat  gtatataca  tatttattt  agggctggg  1920
tataataca  ccgagcccc  aggccctgt  cacccctcc  cgacttcct  ccactaggg  1980
atcctcatc  tctgcatgt  ttaaactga  ctcccctcc  cgcggtgcc  tgccccctc  2040
gggccgcca  taaactgtt  cagctc  2066



<210> 7609
<211> 614
<212> PRT
<213> Rattus norvegicus
<308> AAB24586
<400> 7609

Met Arg Pro Pro Trp Tyr Pro Leu His Thr Pro Ser Leu Ala Ser Pro 
  1               5                  10                  15
Leu Leu Phe Leu Leu Leu Ser Leu Leu Gly Gly Gly Ala Arg Ala Glu 
             20                  25                  30
Gly Arg Glu Asp Pro Gln Leu Leu Val Arg Val Arg Gly Gly Gln Leu 
         35                  40                  45
Arg Gly Ile Arg Leu Lys Ala Pro Gly Gly Pro Val Ser Ala Phe Leu 
     50                  55                  60
Gly Ile Pro Phe Ala Glu Pro Pro Val Gly Ser Arg Arg Phe Met Pro 
 65                  70                  75                  80
Pro Glu Pro Lys Arg Pro Trp Ser Gly Ile Leu Asp Ala Thr Thr Phe 
                 85                  90                  95
Gln Asn Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
             100                105                110
Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
         115                120                125
Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
     130                135                140
Val Leu Ile Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
 145                150                155                160
Leu Asp Val Tyr Asp Gly Arg Phe Leu Ala Gln Val Glu Gly Thr Val 
                 165                170                175
Leu Val Ser Met Asn Tyr Arg Val Gly Thr Phe Gly Phe Leu Ala Leu 
             180                185                190
Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
         195                200                205
Leu Ala Leu Gln Trp Val Gln Glu Asn Ile Ala Ala Phe Gly Gly Asp 
     210                215                220
Pro Met Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
 225                230                235                240
Gly Met His Ile Leu Ser Leu Pro Ser Arg Ser Leu Phe His Arg Ala 
                 245                250                255
Val Leu Gln Ser Gly Thr Pro Asn Gly Pro Trp Ala Thr Val Ser Ala 
             260                265                270
Gly Glu Ala Arg Arg Arg Ala Thr Leu Leu Ala Arg Leu Val Gly Cys 
         275                280                285
Pro Pro Gly Gly Ala Gly Gly Asn Asp Thr Glu Leu Ile Ser Cys Leu 
     290                295                300
Arg Thr Arg Pro Ala Gln Asp Leu Val Asp His Glu Trp His Val Leu 
 305                310                315                320
Pro Gln Glu Ser Ile Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                 325                330                335
Asp Phe Leu Ser Asp Thr Pro Asp Ala Leu Ile Asn Thr Gly Asp Phe 
             340                345                350
Gln Asp Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
         355                360                365
Phe Leu Val Tyr Gly Val Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
     370                375                380
Ile Ser Arg Ala Gln Phe Leu Ala Gly Val Arg Ile Gly Val Pro Gln 
 385                390                395                400
Ala Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                 405                410                415
Leu His Pro Glu Asp Pro Ala His Leu Arg Asp Ala Met Ser Ala Val 
             420                425                430
Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
         435                440                445
Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Ile Phe Glu His Arg 
     450                455                460
Ala Ser Thr Leu Thr Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
 465                470                475                480
Glu Ile Glu Phe Ile Phe Gly Leu Pro Leu Asp Pro Ser Leu Asn Tyr 
                 485                490                495
Thr Val Glu Glu Arg Ile Phe Ala Gln Arg Leu Met Gln Tyr Trp Thr 
             500                505                510
Asn Phe Ala Arg Thr Gly Asp Pro Asn Asp Pro Arg Asp Ser Lys Ser 
         515                520                525
Pro Arg Trp Pro Pro Tyr Thr Thr Ala Ala Gln Gln Tyr Val Ser Leu 
     530                535                540
Asn Leu Lys Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Thr Cys 
 545                550                555                560
Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Asp Thr 
                 565                570                575
Leu Asp Glu Ala Glu Arg Gln Trp Lys Ala Glu Phe His Arg Trp Ser 
             580                585                590
Ser Tyr Met Val His Trp Lys Asn Gln Phe Asp His Tyr Ser Lys Gln 
         595                600                605
Glu Arg Cys Ser Asp Leu 
     610



<210> 7610
<211> 2156
<212> DNA
<213> Homo sapiens
<308> NM_000665
<400> 7610

cagcctgcg  cggggaaca  cggccgcct  cagctcccg  cgcggcccg  cccggcccg  60
ctcggccgc  tcagacgcc  cctgccctg  agccatgag  cccccgcag  gtctgctgc  120
cacgccttc  ctggcttcc  cactccttc  cctcctcct  tggctcctg  gtggaggag  180
gggggctga  ggccgggag  atgcagagc  gctggtgac  gtgcgtggg  gccggctgc  240
gggcattcg  ctgaagacc  ccgggggcc  tgtctctgc  ttcctgggc  tcccctttg  300
ggagccacc  atgggaccc  gtcgctttc  gccaccgga  cccaagcag  cttggtcag  360
ggtggtaga  gctacaacc  tccagagtg  ctgctacca  tatgtggac  ccctatacc  420
aggttttga  ggcaccgag  tgtggaacc  caaccgtga  ctgagcgag  actgcctgt  480
cctcaacgt  tggacacca  acccccggc  tacatcccc  acccctgtc  tcgtctgga  540
ctatggggg  ggcttctac  gtggggcct  ctccttgga  gtgtacgat  gccgcttct  600
ggtacaggc  gagaggact  tgctggtgt  catgaacta  cgggtggga  cctttggct  660
cctggccct  ccggggagc  gagaggccc  gggcaatgt  ggtctcctg  atcagaggc  720
ggccctgca  tgggtgcag  agaacgtgg  agccttcgg  ggtgacccg  catcagtga  780
gctgtttgg  gagagcgcg  gagccgcct  ggtgggcat  cacctgctg  ccccgccca  840
ccggggcct  ttccacagg  ccgtgctgc  gagcggtgc  cccaatgga  cctgggcca  900
ggtgggcat  ggagaggcc  gtcgcaggg  cacgcagct  gcccacctt  tgggctgtc  960
tccaggcgg  actggtggg  atgacacag  gctggtagc  tgccttcgg  cacgaccag  1020
gcaggtcct  gtgaaccac  aatggcacg  gctgcctca  gaaagcgtc  tccggttct  1080
cttcgtgcc  gtggtagat  gagacttcc  cagtgacac  ccagaggcc  tcatcaacg  1140
gggagactt  cacggcctg  aggtgctgg  gggtgtggt  aaggatgag  gctcgtatt  1200
tctggttta  ggggcccca  gcttcagca  agacaacga  tctctcatc  gccgggccg  1260
gttcctggc  ggggtgcgg  tcggggttc  ccaggtaag  gacctggca  ccgaggctg  1320
ggtcctgca  tacacagac  ggctgcatc  cgaggaccc  gcacgcctg  gggaggccc  1380
gagcgatgt  gtgggcgac  acaatgtcg  gtgccccgt  gcccagctg  ctgggcgac  1440
ggctgccca  ggtgcccgg  tctacgcct  cgtctttga  caccgtgct  ccacgctct  1500
ctggcccct  tggatgggg  tgccccacg  ctacgagat  gagttcatc  ttgggatcc  1560
cctggaccc  tctcgaaac  acacggcag  ggagaaaat  ttcgcccag  gactgatgc  1620
atactgggc  aactttgcc  gcacagggg  tcccaatga  ccccgagac  ccaaggccc  1680
acaatggcc  ccgtacacg  cgggggctc  gcagtacgt  agtctggac  tgcggccgc  1740
ggaggtgcg  cgggggctg  gcgcccagg  ctgcgcctt  tggaaccgc  tcctcccca  1800
attgctcag  gccaccgac  cgctcgacg  ggcggagcg  cagtggaag  ccgagttcc  1860
ccgctggag  tcctacatg  tgcactgga  gaaccagtt  gaccactac  gcaagcagg  1920
tcgctgctc  gacctgtga  cccggcggg  cccccatgt  ctccgctcc  cccggcccc  1980
tagctgtat  tactattta  ttcagggct  ggctataac  cagacgagc  ccagactct  2040
cccatcccc  ccccacccc  acgtccccc  gggctcccg  tcctctggc  tgtcttcag  2100
ctgagctcc  ccccgcgtg  cttcgccct  tggctgcaa  taaactgtt  caggcc  2156



<210> 7611
<211> 614
<212> PRT
<213> Homo sapiens
<308> P22303
<400> 7611

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
  1               5                  10                  15
Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
             20                  25                  30
Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
         35                  40                  45
Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
     50                  55                  60
Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
 65                  70                  75                  80
Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                 85                  90                  95
Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
             100                105                110
Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
         115                120                125
Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
     130                135                140
Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
 145                150                155                160
Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                 165                170                175
Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
             180                185                190
Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
         195                200                205
Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
     210                215                220
Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
 225                230                235                240
Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                 245                250                255
Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
             260                265                270
Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
         275                280                285
Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
     290                295                300
Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
 305                310                315                320
Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                 325                330                335
Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
             340                345                350
His Gly Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
         355                360                365
Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
     370                375                380
Ile Ser Arg Ala Glu Phe Leu Ala Gly Val Arg Val Gly Val Pro Gln 
 385                390                395                400
Val Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                 405                410                415
Leu His Pro Glu Asp Pro Ala Arg Leu Arg Glu Ala Leu Ser Asp Val 
             420                425                430
Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
         435                440                445
Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Val Phe Glu His Arg 
     450                455                460
Ala Ser Thr Leu Ser Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
 465                470                475                480
Glu Ile Glu Phe Ile Phe Gly Ile Pro Leu Asp Pro Ser Arg Asn Tyr 
                 485                490                495
Thr Ala Glu Glu Lys Ile Phe Ala Gln Arg Leu Met Arg Tyr Trp Ala 
             500                505                510
Asn Phe Ala Arg Thr Gly Asp Pro Asn Glu Pro Arg Asp Pro Lys Ala 
         515                520                525
Pro Gln Trp Pro Pro Tyr Thr Ala Gly Ala Gln Gln Tyr Val Ser Leu 
     530                535                540
Asp Leu Arg Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Ala Cys 
 545                550                555                560
Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Asp Thr 
                 565                570                575
Leu Asp Glu Ala Glu Arg Gln Trp Lys Ala Glu Phe His Arg Trp Ser 
             580                585                590
Ser Tyr Met Val His Trp Lys Asn Gln Phe Asp His Tyr Ser Lys Gln 
         595                600                605
Asp Arg Cys Ser Asp Leu 
     610



<210> 7612
<211> 2066
<212> DNA
<213> Rattus norvegicus
<308> S50879
<400> 7612

atgaggcct  cctggtatc  cctgcatac  ccctccctg  cttctccac  cctcttcct  60
ctcctctcc  tcctgggag  aggggcaag  gctgagggc  gggaagacc  tcagctgct  120
gtgagggtt  gagggggcc  gctgagggg  atccgcctg  aggcccctg  aggcccagt  180
tcagctttt  tgggcatcc  ctttgcaga  ccacctgtg  gctcacgta  atttatgcc  240
ccagagccc  agcgcccct  gtcaggaat  ttggatgct  ccaccttcc  aaatgtctg  300
taccaatac  tggacaccc  gtaccctgg  tttgagggt  ccgagatgt  gaaccccaa  360
cgagagctg  gtgaagact  cctttatct  aatgtgtgg  caccatacc  caggcctac  420
tctcccaca  ctgtcctca  ctggatcta  gggggtggt  tctacagtg  agcatcctc  480
ttggacgtg  atgacggcc  tttcctggc  caggttgag  gaaccgtgt  ggtatctat  540
aactaccga  tgggaacct  tggcttctt  gctctacca  gaagcagag  agcccctgg  600
aatgtaggc  tgctggatc  acggcttgc  ttgcaatgg  tacaagaaa  tatcgcagc  660
tttggggga  acccaatgt  agtgactct  tttggggag  gtgcaggtg  agcctcagt  720
ggcatgcac  ttctgtccc  gcccagcag  agcctcttc  acagggctg  cctgcagag  780
ggcacaccc  atgggccct  ggccactgt  agtgcggga  aggccaggc  cagggccac  840
ctgctggcc  gccttgtgg  ctgtccccc  ggtggcgct  gtggcaatg  caccgagct  900
atatcctgc  tgaggacaa  gcccgctca  gacctggtg  accacgagt  gcatgtgct  960
cctcaagaa  gtatcttcc  gttttcctt  gtgcctgtg  tggacgggg  tttcctcag  1020
gacacgccg  acgctctca  caatactgg  gattttcaa  acctgcagg  gctggtggg  1080
gtggtgaag  acgagggct  ctactttct  gtttacggg  tcccaggct  cagcaaaga  1140
aatgaatct  tcatcagcc  ggcccagtt  ctggctggg  tgcggatcg  tgtacccca  1200
gcgagtgac  tggcggccg  ggctgtggt  ctgcattat  cagactggc  gcaccctga  1260
gaccctgcc  acctgagag  tgccatgag  gcggtggta  gcgaccaca  cgttgtgtg  1320
cctgtggcc  agctggctg  gcgactggc  gcccaaggg  ctcgggtct  tgcctacat  1380
tttgaacac  gtgcctcca  attgacttg  cccctctgg  tgggggtgc  ccatggcta  1440
gaaatcgag  tcatctttg  gctccccct  gatccctca  tgaactaca  cgtggagga  1500
agaatcttt  ctcagcgac  tatgcaata  tggaccaat  ttgcccgca  aggggaccc  1560
aatgaccct  gagactcta  gtctccacg  tggccaccg  acaccactg  cgcgcagca  1620
tacgtgagc  tgaacctga  gcctttgga  gtgcggcgg  gactgcgcg  ccagacctg  1680
gccttctgg  atcgttttc  ccccaaatt  ctcagcgcc  cagacacgc  ggacgaggc  1740
gagcgccag  ggaaggccg  gttccaccg  tggagctcc  acatggtgc  ctggaagaa  1800
cagttcgac  actatagca  gcaggaacg  tgctcagac  tgtgacccc  tggggaccc  1860
ggtcctgcc  tcctgcccg  gcccctgat  gtatataca  tatttattt  agggctggg  1920
tataataca  ccgagcccc  aggccctgt  cacccctcc  cgacttcct  ccactaggg  1980
atcctcatc  tctgcatgt  ttaaactga  ctcccctcc  cgcggtgcc  tgccccctc  2040
gggccgcca  taaactgtt  cagctc  2066



<210> 7613
<211> 614
<212> PRT
<213> Rattus norvegicus
<308> AAB24586
<400> 7613

Met Arg Pro Pro Trp Tyr Pro Leu His Thr Pro Ser Leu Ala Ser Pro 
  1               5                  10                  15
Leu Leu Phe Leu Leu Leu Ser Leu Leu Gly Gly Gly Ala Arg Ala Glu 
             20                  25                  30
Gly Arg Glu Asp Pro Gln Leu Leu Val Arg Val Arg Gly Gly Gln Leu 
         35                  40                  45
Arg Gly Ile Arg Leu Lys Ala Pro Gly Gly Pro Val Ser Ala Phe Leu 
     50                  55                  60
Gly Ile Pro Phe Ala Glu Pro Pro Val Gly Ser Arg Arg Phe Met Pro 
 65                  70                  75                  80
Pro Glu Pro Lys Arg Pro Trp Ser Gly Ile Leu Asp Ala Thr Thr Phe 
                 85                  90                  95
Gln Asn Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
             100                105                110
Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
         115                120                125
Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
     130                135                140
Val Leu Ile Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
 145                150                155                160
Leu Asp Val Tyr Asp Gly Arg Phe Leu Ala Gln Val Glu Gly Thr Val 
                 165                170                175
Leu Val Ser Met Asn Tyr Arg Val Gly Thr Phe Gly Phe Leu Ala Leu 
             180                185                190
Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
         195                200                205
Leu Ala Leu Gln Trp Val Gln Glu Asn Ile Ala Ala Phe Gly Gly Asp 
     210                215                220
Pro Met Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
 225                230                235                240
Gly Met His Ile Leu Ser Leu Pro Ser Arg Ser Leu Phe His Arg Ala 
                 245                250                255
Val Leu Gln Ser Gly Thr Pro Asn Gly Pro Trp Ala Thr Val Ser Ala 
             260                265                270
Gly Glu Ala Arg Arg Arg Ala Thr Leu Leu Ala Arg Leu Val Gly Cys 
         275                280                285
Pro Pro Gly Gly Ala Gly Gly Asn Asp Thr Glu Leu Ile Ser Cys Leu 
     290                295                300
Arg Thr Arg Pro Ala Gln Asp Leu Val Asp His Glu Trp His Val Leu 
 305                310                315                320
Pro Gln Glu Ser Ile Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                 325                330                335
Asp Phe Leu Ser Asp Thr Pro Asp Ala Leu Ile Asn Thr Gly Asp Phe 
             340                345                350
Gln Asp Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
         355                360                365
Phe Leu Val Tyr Gly Val Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
     370                375                380
Ile Ser Arg Ala Gln Phe Leu Ala Gly Val Arg Ile Gly Val Pro Gln 
 385                390                395                400
Ala Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                 405                410                415
Leu His Pro Glu Asp Pro Ala His Leu Arg Asp Ala Met Ser Ala Val 
             420                425                430
Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
         435                440                445
Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Ile Phe Glu His Arg 
     450                455                460
Ala Ser Thr Leu Thr Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
 465                470                475                480
Glu Ile Glu Phe Ile Phe Gly Leu Pro Leu Asp Pro Ser Leu Asn Tyr 
                 485                490                495
Thr Val Glu Glu Arg Ile Phe Ala Gln Arg Leu Met Gln Tyr Trp Thr 
             500                505                510
Asn Phe Ala Arg Thr Gly Asp Pro Asn Asp Pro Arg Asp Ser Lys Ser 
         515                520                525
Pro Arg Trp Pro Pro Tyr Thr Thr Ala Ala Gln Gln Tyr Val Ser Leu 
     530                535                540
Asn Leu Lys Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Thr Cys 
 545                550                555                560
Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Asp Thr 
                 565                570                575
Leu Asp Glu Ala Glu Arg Gln Trp Lys Ala Glu Phe His Arg Trp Ser 
             580                585                590
Ser Tyr Met Val His Trp Lys Asn Gln Phe Asp His Tyr Ser Lys Gln 
         595                600                605
Glu Arg Cys Ser Asp Leu 
     610



<210> 7614
<211> 2156
<212> DNA
<213> Homo sapiens
<308> NM_000665
<400> 7614

cagcctgcg  cggggaaca  cggccgcct  cagctcccg  cgcggcccg  cccggcccg  60
ctcggccgc  tcagacgcc  cctgccctg  agccatgag  cccccgcag  gtctgctgc  120
cacgccttc  ctggcttcc  cactccttc  cctcctcct  tggctcctg  gtggaggag  180
gggggctga  ggccgggag  atgcagagc  gctggtgac  gtgcgtggg  gccggctgc  240
gggcattcg  ctgaagacc  ccgggggcc  tgtctctgc  ttcctgggc  tcccctttg  300
ggagccacc  atgggaccc  gtcgctttc  gccaccgga  cccaagcag  cttggtcag  360
ggtggtaga  gctacaacc  tccagagtg  ctgctacca  tatgtggac  ccctatacc  420
aggttttga  ggcaccgag  tgtggaacc  caaccgtga  ctgagcgag  actgcctgt  480
cctcaacgt  tggacacca  acccccggc  tacatcccc  acccctgtc  tcgtctgga  540
ctatggggg  ggcttctac  gtggggcct  ctccttgga  gtgtacgat  gccgcttct  600
ggtacaggc  gagaggact  tgctggtgt  catgaacta  cgggtggga  cctttggct  660
cctggccct  ccggggagc  gagaggccc  gggcaatgt  ggtctcctg  atcagaggc  720
ggccctgca  tgggtgcag  agaacgtgg  agccttcgg  ggtgacccg  catcagtga  780
gctgtttgg  gagagcgcg  gagccgcct  ggtgggcat  cacctgctg  ccccgccca  840
ccggggcct  ttccacagg  ccgtgctgc  gagcggtgc  cccaatgga  cctgggcca  900
ggtgggcat  ggagaggcc  gtcgcaggg  cacgcagct  gcccacctt  tgggctgtc  960
tccaggcgg  actggtggg  atgacacag  gctggtagc  tgccttcgg  cacgaccag  1020
gcaggtcct  gtgaaccac  aatggcacg  gctgcctca  gaaagcgtc  tccggttct  1080
cttcgtgcc  gtggtagat  gagacttcc  cagtgacac  ccagaggcc  tcatcaacg  1140
gggagactt  cacggcctg  aggtgctgg  gggtgtggt  aaggatgag  gctcgtatt  1200
tctggttta  ggggcccca  gcttcagca  agacaacga  tctctcatc  gccgggccg  1260
gttcctggc  ggggtgcgg  tcggggttc  ccaggtaag  gacctggca  ccgaggctg  1320
ggtcctgca  tacacagac  ggctgcatc  cgaggaccc  gcacgcctg  gggaggccc  1380
gagcgatgt  gtgggcgac  acaatgtcg  gtgccccgt  gcccagctg  ctgggcgac  1440
ggctgccca  ggtgcccgg  tctacgcct  cgtctttga  caccgtgct  ccacgctct  1500
ctggcccct  tggatgggg  tgccccacg  ctacgagat  gagttcatc  ttgggatcc  1560
cctggaccc  tctcgaaac  acacggcag  ggagaaaat  ttcgcccag  gactgatgc  1620
atactgggc  aactttgcc  gcacagggg  tcccaatga  ccccgagac  ccaaggccc  1680
acaatggcc  ccgtacacg  cgggggctc  gcagtacgt  agtctggac  tgcggccgc  1740
ggaggtgcg  cgggggctg  gcgcccagg  ctgcgcctt  tggaaccgc  tcctcccca  1800
attgctcag  gccaccgac  cgctcgacg  ggcggagcg  cagtggaag  ccgagttcc  1860
ccgctggag  tcctacatg  tgcactgga  gaaccagtt  gaccactac  gcaagcagg  1920
tcgctgctc  gacctgtga  cccggcggg  cccccatgt  ctccgctcc  cccggcccc  1980
tagctgtat  tactattta  ttcagggct  ggctataac  cagacgagc  ccagactct  2040
cccatcccc  ccccacccc  acgtccccc  gggctcccg  tcctctggc  tgtcttcag  2100
ctgagctcc  ccccgcgtg  cttcgccct  tggctgcaa  taaactgtt  caggcc  2156



<210> 7615
<211> 614
<212> PRT
<213> Homo sapiens
<308> P22303
<400> 7615

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
  1               5                  10                  15
Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
             20                  25                  30
Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
         35                  40                  45
Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
     50                  55                  60
Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
 65                  70                  75                  80
Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                 85                  90                  95
Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
             100                105                110
Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
         115                120                125
Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
     130                135                140
Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
 145                150                155                160
Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                 165                170                175
Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
             180                185                190
Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
         195                200                205
Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
     210                215                220
Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
 225                230                235                240
Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                 245                250                255
Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
             260                265                270
Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
         275                280                285
Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
     290                295                300
Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
 305                310                315                320
Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                 325                330                335
Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
             340                345                350
His Gly Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
         355                360                365
Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
     370                375                380
Ile Ser Arg Ala Glu Phe Leu Ala Gly Val Arg Val Gly Val Pro Gln 
 385                390                395                400
Val Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                 405                410                415
Leu His Pro Glu Asp Pro Ala Arg Leu Arg Glu Ala Leu Ser Asp Val 
             420                425                430
Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
         435                440                445
Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Val Phe Glu His Arg 
     450                455                460
Ala Ser Thr Leu Ser Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
 465                470                475                480
Glu Ile Glu Phe Ile Phe Gly Ile Pro Leu Asp Pro Ser Arg Asn Tyr 
                 485                490                495
Thr Ala Glu Glu Lys Ile Phe Ala Gln Arg Leu Met Arg Tyr Trp Ala 
             500                505                510
Asn Phe Ala Arg Thr Gly Asp Pro Asn Glu Pro Arg Asp Pro Lys Ala 
         515                520                525
Pro Gln Trp Pro Pro Tyr Thr Ala Gly Ala Gln Gln Tyr Val Ser Leu 
     530                535                540
Asp Leu Arg Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Ala Cys 
 545                550                555                560
Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Asp Thr 
                 565                570                575
Leu Asp Glu Ala Glu Arg Gln Trp Lys Ala Glu Phe His Arg Trp Ser 
             580                585                590
Ser Tyr Met Val His Trp Lys Asn Gln Phe Asp His Tyr Ser Lys Gln 
         595                600                605
Asp Arg Cys Ser Asp Leu 
     610



<210> 7616
<211> 2066
<212> DNA
<213> Rattus norvegicus
<308> S50879
<400> 7616

atgaggcct  cctggtatc  cctgcatac  ccctccctg  cttctccac  cctcttcct  60
ctcctctcc  tcctgggag  aggggcaag  gctgagggc  gggaagacc  tcagctgct  120
gtgagggtt  gagggggcc  gctgagggg  atccgcctg  aggcccctg  aggcccagt  180
tcagctttt  tgggcatcc  ctttgcaga  ccacctgtg  gctcacgta  atttatgcc  240
ccagagccc  agcgcccct  gtcaggaat  ttggatgct  ccaccttcc  aaatgtctg  300
taccaatac  tggacaccc  gtaccctgg  tttgagggt  ccgagatgt  gaaccccaa  360
cgagagctg  gtgaagact  cctttatct  aatgtgtgg  caccatacc  caggcctac  420
tctcccaca  ctgtcctca  ctggatcta  gggggtggt  tctacagtg  agcatcctc  480
ttggacgtg  atgacggcc  tttcctggc  caggttgag  gaaccgtgt  ggtatctat  540
aactaccga  tgggaacct  tggcttctt  gctctacca  gaagcagag  agcccctgg  600
aatgtaggc  tgctggatc  acggcttgc  ttgcaatgg  tacaagaaa  tatcgcagc  660
tttggggga  acccaatgt  agtgactct  tttggggag  gtgcaggtg  agcctcagt  720
ggcatgcac  ttctgtccc  gcccagcag  agcctcttc  acagggctg  cctgcagag  780
ggcacaccc  atgggccct  ggccactgt  agtgcggga  aggccaggc  cagggccac  840
ctgctggcc  gccttgtgg  ctgtccccc  ggtggcgct  gtggcaatg  caccgagct  900
atatcctgc  tgaggacaa  gcccgctca  gacctggtg  accacgagt  gcatgtgct  960
cctcaagaa  gtatcttcc  gttttcctt  gtgcctgtg  tggacgggg  tttcctcag  1020
gacacgccg  acgctctca  caatactgg  gattttcaa  acctgcagg  gctggtggg  1080
gtggtgaag  acgagggct  ctactttct  gtttacggg  tcccaggct  cagcaaaga  1140
aatgaatct  tcatcagcc  ggcccagtt  ctggctggg  tgcggatcg  tgtacccca  1200
gcgagtgac  tggcggccg  ggctgtggt  ctgcattat  cagactggc  gcaccctga  1260
gaccctgcc  acctgagag  tgccatgag  gcggtggta  gcgaccaca  cgttgtgtg  1320
cctgtggcc  agctggctg  gcgactggc  gcccaaggg  ctcgggtct  tgcctacat  1380
tttgaacac  gtgcctcca  attgacttg  cccctctgg  tgggggtgc  ccatggcta  1440
gaaatcgag  tcatctttg  gctccccct  gatccctca  tgaactaca  cgtggagga  1500
agaatcttt  ctcagcgac  tatgcaata  tggaccaat  ttgcccgca  aggggaccc  1560
aatgaccct  gagactcta  gtctccacg  tggccaccg  acaccactg  cgcgcagca  1620
tacgtgagc  tgaacctga  gcctttgga  gtgcggcgg  gactgcgcg  ccagacctg  1680
gccttctgg  atcgttttc  ccccaaatt  ctcagcgcc  cagacacgc  ggacgaggc  1740
gagcgccag  ggaaggccg  gttccaccg  tggagctcc  acatggtgc  ctggaagaa  1800
cagttcgac  actatagca  gcaggaacg  tgctcagac  tgtgacccc  tggggaccc  1860
ggtcctgcc  tcctgcccg  gcccctgat  gtatataca  tatttattt  agggctggg  1920
tataataca  ccgagcccc  aggccctgt  cacccctcc  cgacttcct  ccactaggg  1980
atcctcatc  tctgcatgt  ttaaactga  ctcccctcc  cgcggtgcc  tgccccctc  2040
gggccgcca  taaactgtt  cagctc  2066



<210> 7617
<211> 614
<212> PRT
<213> Rattus norvegicus
<308> AAB24586
<400> 7617

Met Arg Pro Pro Trp Tyr Pro Leu His Thr Pro Ser Leu Ala Ser Pro 
  1               5                  10                  15
Leu Leu Phe Leu Leu Leu Ser Leu Leu Gly Gly Gly Ala Arg Ala Glu 
             20                  25                  30
Gly Arg Glu Asp Pro Gln Leu Leu Val Arg Val Arg Gly Gly Gln Leu 
         35                  40                  45
Arg Gly Ile Arg Leu Lys Ala Pro Gly Gly Pro Val Ser Ala Phe Leu 
     50                  55                  60
Gly Ile Pro Phe Ala Glu Pro Pro Val Gly Ser Arg Arg Phe Met Pro 
 65                  70                  75                  80
Pro Glu Pro Lys Arg Pro Trp Ser Gly Ile Leu Asp Ala Thr Thr Phe 
                 85                  90                  95
Gln Asn Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
             100                105                110
Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
         115                120                125
Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
     130                135                140
Val Leu Ile Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
 145                150                155                160
Leu Asp Val Tyr Asp Gly Arg Phe Leu Ala Gln Val Glu Gly Thr Val 
                 165                170                175
Leu Val Ser Met Asn Tyr Arg Val Gly Thr Phe Gly Phe Leu Ala Leu 
             180                185                190
Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
         195                200                205
Leu Ala Leu Gln Trp Val Gln Glu Asn Ile Ala Ala Phe Gly Gly Asp 
     210                215                220
Pro Met Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
 225                230                235                240
Gly Met His Ile Leu Ser Leu Pro Ser Arg Ser Leu Phe His Arg Ala 
                 245                250                255
Val Leu Gln Ser Gly Thr Pro Asn Gly Pro Trp Ala Thr Val Ser Ala 
             260                265                270
Gly Glu Ala Arg Arg Arg Ala Thr Leu Leu Ala Arg Leu Val Gly Cys 
         275                280                285
Pro Pro Gly Gly Ala Gly Gly Asn Asp Thr Glu Leu Ile Ser Cys Leu 
     290                295                300
Arg Thr Arg Pro Ala Gln Asp Leu Val Asp His Glu Trp His Val Leu 
 305                310                315                320
Pro Gln Glu Ser Ile Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                 325                330                335
Asp Phe Leu Ser Asp Thr Pro Asp Ala Leu Ile Asn Thr Gly Asp Phe 
             340                345                350
Gln Asp Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
         355                360                365
Phe Leu Val Tyr Gly Val Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
     370                375                380
Ile Ser Arg Ala Gln Phe Leu Ala Gly Val Arg Ile Gly Val Pro Gln 
 385                390                395                400
Ala Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                 405                410                415
Leu His Pro Glu Asp Pro Ala His Leu Arg Asp Ala Met Ser Ala Val 
             420                425                430
Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
         435                440                445
Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Ile Phe Glu His Arg 
     450                455                460
Ala Ser Thr Leu Thr Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
 465                470                475                480
Glu Ile Glu Phe Ile Phe Gly Leu Pro Leu Asp Pro Ser Leu Asn Tyr 
                 485                490                495
Thr Val Glu Glu Arg Ile Phe Ala Gln Arg Leu Met Gln Tyr Trp Thr 
             500                505                510
Asn Phe Ala Arg Thr Gly Asp Pro Asn Asp Pro Arg Asp Ser Lys Ser 
         515                520                525
Pro Arg Trp Pro Pro Tyr Thr Thr Ala Ala Gln Gln Tyr Val Ser Leu 
     530                535                540
Asn Leu Lys Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Thr Cys 
 545                550                555                560
Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Asp Thr 
                 565                570                575
Leu Asp Glu Ala Glu Arg Gln Trp Lys Ala Glu Phe His Arg Trp Ser 
             580                585                590
Ser Tyr Met Val His Trp Lys Asn Gln Phe Asp His Tyr Ser Lys Gln 
         595                600                605
Glu Arg Cys Ser Asp Leu 
     610



<210> 7618
<211> 2156
<212> DNA
<213> Homo sapiens
<308> NM_000665
<400> 7618

cagcctgcg  cggggaaca  cggccgcct  cagctcccg  cgcggcccg  cccggcccg  60
ctcggccgc  tcagacgcc  cctgccctg  agccatgag  cccccgcag  gtctgctgc  120
cacgccttc  ctggcttcc  cactccttc  cctcctcct  tggctcctg  gtggaggag  180
gggggctga  ggccgggag  atgcagagc  gctggtgac  gtgcgtggg  gccggctgc  240
gggcattcg  ctgaagacc  ccgggggcc  tgtctctgc  ttcctgggc  tcccctttg  300
ggagccacc  atgggaccc  gtcgctttc  gccaccgga  cccaagcag  cttggtcag  360
ggtggtaga  gctacaacc  tccagagtg  ctgctacca  tatgtggac  ccctatacc  420
aggttttga  ggcaccgag  tgtggaacc  caaccgtga  ctgagcgag  actgcctgt  480
cctcaacgt  tggacacca  acccccggc  tacatcccc  acccctgtc  tcgtctgga  540
ctatggggg  ggcttctac  gtggggcct  ctccttgga  gtgtacgat  gccgcttct  600
ggtacaggc  gagaggact  tgctggtgt  catgaacta  cgggtggga  cctttggct  660
cctggccct  ccggggagc  gagaggccc  gggcaatgt  ggtctcctg  atcagaggc  720
ggccctgca  tgggtgcag  agaacgtgg  agccttcgg  ggtgacccg  catcagtga  780
gctgtttgg  gagagcgcg  gagccgcct  ggtgggcat  cacctgctg  ccccgccca  840
ccggggcct  ttccacagg  ccgtgctgc  gagcggtgc  cccaatgga  cctgggcca  900
ggtgggcat  ggagaggcc  gtcgcaggg  cacgcagct  gcccacctt  tgggctgtc  960
tccaggcgg  actggtggg  atgacacag  gctggtagc  tgccttcgg  cacgaccag  1020
gcaggtcct  gtgaaccac  aatggcacg  gctgcctca  gaaagcgtc  tccggttct  1080
cttcgtgcc  gtggtagat  gagacttcc  cagtgacac  ccagaggcc  tcatcaacg  1140
gggagactt  cacggcctg  aggtgctgg  gggtgtggt  aaggatgag  gctcgtatt  1200
tctggttta  ggggcccca  gcttcagca  agacaacga  tctctcatc  gccgggccg  1260
gttcctggc  ggggtgcgg  tcggggttc  ccaggtaag  gacctggca  ccgaggctg  1320
ggtcctgca  tacacagac  ggctgcatc  cgaggaccc  gcacgcctg  gggaggccc  1380
gagcgatgt  gtgggcgac  acaatgtcg  gtgccccgt  gcccagctg  ctgggcgac  1440
ggctgccca  ggtgcccgg  tctacgcct  cgtctttga  caccgtgct  ccacgctct  1500
ctggcccct  tggatgggg  tgccccacg  ctacgagat  gagttcatc  ttgggatcc  1560
cctggaccc  tctcgaaac  acacggcag  ggagaaaat  ttcgcccag  gactgatgc  1620
atactgggc  aactttgcc  gcacagggg  tcccaatga  ccccgagac  ccaaggccc  1680
acaatggcc  ccgtacacg  cgggggctc  gcagtacgt  agtctggac  tgcggccgc  1740
ggaggtgcg  cgggggctg  gcgcccagg  ctgcgcctt  tggaaccgc  tcctcccca  1800
attgctcag  gccaccgac  cgctcgacg  ggcggagcg  cagtggaag  ccgagttcc  1860
ccgctggag  tcctacatg  tgcactgga  gaaccagtt  gaccactac  gcaagcagg  1920
tcgctgctc  gacctgtga  cccggcggg  cccccatgt  ctccgctcc  cccggcccc  1980
tagctgtat  tactattta  ttcagggct  ggctataac  cagacgagc  ccagactct  2040
cccatcccc  ccccacccc  acgtccccc  gggctcccg  tcctctggc  tgtcttcag  2100
ctgagctcc  ccccgcgtg  cttcgccct  tggctgcaa  taaactgtt  caggcc  2156



<210> 7619
<211> 614
<212> PRT
<213> Homo sapiens
<308> P22303
<400> 7619

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
  1               5                  10                  15
Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
             20                  25                  30
Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
         35                  40                  45
Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
     50                  55                  60
Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
 65                  70                  75                  80
Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                 85                  90                  95
Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
             100                105                110
Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
         115                120                125
Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
     130                135                140
Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
 145                150                155                160
Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                 165                170                175
Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
             180                185                190
Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
         195                200                205
Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
     210                215                220
Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
 225                230                235                240
Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                 245                250                255
Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
             260                265                270
Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
         275                280                285
Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
     290                295                300
Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
 305                310                315                320
Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                 325                330                335
Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
             340                345                350
His Gly Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
         355                360                365
Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
     370                375                380
Ile Ser Arg Ala Glu Phe Leu Ala Gly Val Arg Val Gly Val Pro Gln 
 385                390                395                400
Val Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                 405                410                415
Leu His Pro Glu Asp Pro Ala Arg Leu Arg Glu Ala Leu Ser Asp Val 
             420                425                430
Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
         435                440                445
Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Val Phe Glu His Arg 
     450                455                460
Ala Ser Thr Leu Ser Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
 465                470                475                480
Glu Ile Glu Phe Ile Phe Gly Ile Pro Leu Asp Pro Ser Arg Asn Tyr 
                 485                490                495
Thr Ala Glu Glu Lys Ile Phe Ala Gln Arg Leu Met Arg Tyr Trp Ala 
             500                505                510
Asn Phe Ala Arg Thr Gly Asp Pro Asn Glu Pro Arg Asp Pro Lys Ala 
         515                520                525
Pro Gln Trp Pro Pro Tyr Thr Ala Gly Ala Gln Gln Tyr Val Ser Leu 
     530                535                540
Asp Leu Arg Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Ala Cys 
 545                550                555                560
Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Asp Thr 
                 565                570                575
Leu Asp Glu Ala Glu Arg Gln Trp Lys Ala Glu Phe His Arg Trp Ser 
             580                585                590
Ser Tyr Met Val His Trp Lys Asn Gln Phe Asp His Tyr Ser Lys Gln 
         595                600                605
Asp Arg Cys Ser Asp Leu 
     610



<210> 7621
<211> 822
<212> PRT
<213> Rattus norvegicus
<308> Q04589
<400> 7621

Met Trp Gly Trp Arg Gly Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
  1               5                  10                  15
Thr Leu Cys Thr Ala Arg Pro Ala Pro Thr Leu Pro Glu Gln Ala Gln 
             20                  25                  30
Pro Trp Gly Val Pro Val Glu Val Glu Ser Leu Leu Val His Pro Gly 
         35                  40                  45
Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
     50                  55                  60
Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
 65                  70                  75                  80
Ile Thr Gly Glu Glu Val Glu Val Arg Asp Ser Ile Pro Ala Asp Ser 
                 85                  90                  95
Gly Leu Tyr Ala Cys Val Thr Asn Ser Pro Ser Gly Ser Asp Thr Thr 
             100                105                110
Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
         115                120                125
Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
     130                135                140
Lys Pro Asn Arg Arg Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
 145                150                155                160
Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                 165                170                175
Lys Cys Pro Ser Ser Gly Thr Pro Ser Pro Thr Leu Arg Trp Leu Lys 
             180                185                190
Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
         195                200                205
Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
     210                215                220
Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
 225                230                235                240
His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                 245                250                255
Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
             260                265                270
Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
         275                280                285
Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
     290                295                300
Leu Pro Tyr Asp Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
 305                310                315                320
Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                 325                330                335
Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
             340                345                350
Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
         355                360                365
Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
     370                375                380
Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Ile Tyr Lys Met Lys 
 385                390                395                400
Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                 405                410                415
Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
             420                425                430
Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
         435                440                445
Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
     450                455                460
Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
 465                470                475                480
Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                 485                490                495
Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
             500                505                510
Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
         515                520                525
Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
     530                535                540
Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
 545                550                555                560
Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                 565                570                575
Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
             580                585                590
Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
         595                600                605
Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
     610                615                620
Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
 625                630                635                640
Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                 645                650                655
Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
             660                665                670
Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
         675                680                685
Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Asn Pro Gly Val 
     690                695                700
Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
 705                710                715                720
Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                 725                730                735
Trp Asn Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
             740                745                750
Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
         755                760                765
Leu Ser Met Pro Leu Asp Gln Asp Ser Pro Ser Phe Pro Asp Thr Arg 
     770                775                780
Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
 785                790                795                800
Phe Pro Glu Glu Pro Cys Leu Pro Arg His Pro Thr Gln Leu Ala Asn 
                 805                810                815
Gly Gly Leu Asn Arg Arg 
             820



<210> 7622
<211> 3328
<212> DNA
<213> Homo sapiens
<308> M37722
<400> 7622

ccggccgcg  agctcttgc  accccgcca  gacccgaac  gagcccggg  gcggcgggc  2580
ggagccggg  acgcgggca  acgcccgct  gcacaagcc  cggcggact  tcccgaggc  2640
gaacctcca  gccgagcga  ggtcagttt  aaaaggagg  tcgagctca  tgtggagta  2700
ccatggaga  gtggagcct  gtcaccaac  tctaactgc  gaactggga  gtggagctg  2760
aagtgcctc  tcttctggg  tgtgctggt  acagcaaca  tctgcaccg  taggccgtc  2820
ccgaccttg  ctgaacaag  tgctctccc  tcctcggag  atgatgatg  tgatgatga  2880
tcctcttca  aggagaaag  aacagataa  accaaacca  accccgtag  tccatattg  2940
acatcccca  aaaagatgg  aaagaaatt  catgcagtg  cggctgcca  gacagtgaa  3000
ttcaaatgc  cttccagtg  gaccccaaa  cccacactg  gctggttga  aaatggcaa  3060
gaattcaaa  ctgaccaca  aattggagg  tacaaggtc  gttatgcca  ctggagcat  3120
ataatggac  ctgtggtgc  ctctgacaa  ggcaactac  cctgcattg  ggagaatga  3180
tacggcagc  tcaaccaca  ataccagct  gatgtcgtg  agcggtccc  tcaccggcc  3240
atcctgcaa  cagggttgc  cgccaacaa  acagtggcc  tgggtagca  cgtggagtt  3300
atgtgtaag  tgtacagtg  cccgcagc  3328



<210> 7623
<211> 822
<212> PRT
<213> Homo sapiens
<308> P11362
<400> 7623

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
  1               5                  10                  15
Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
             20                  25                  30
Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
         35                  40                  45
Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
     50                  55                  60
Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
 65                  70                  75                  80
Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                 85                  90                  95
Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
             100                105                110
Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
         115                120                125
Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
     130                135                140
Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
 145                150                155                160
Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                 165                170                175
Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
             180                185                190
Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
         195                200                205
Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
     210                215                220
Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
 225                230                235                240
His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                 245                250                255
Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
             260                265                270
Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
         275                280                285
Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
     290                295                300
Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
 305                310                315                320
Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                 325                330                335
Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
             340                345                350
Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
         355                360                365
Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
     370                375                380
Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
 385                390                395                400
Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                 405                410                415
Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
             420                425                430
Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
         435                440                445
Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
     450                455                460
Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
 465                470                475                480
Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                 485                490                495
Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
             500                505                510
Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
         515                520                525
Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
     530                535                540
Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
 545                550                555                560
Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                 565                570                575
Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
             580                585                590
Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
         595                600                605
Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
     610                615                620
Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
 625                630                635                640
Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                 645                650                655
Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
             660                665                670
Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
         675                680                685
Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val 
     690                695                700
Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
 705                710                715                720
Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                 725                730                735
Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
             740                745                750
Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
         755                760                765
Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg 
     770                775                780
Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
 785                790                795                800
Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn 
                 805                810                815
Gly Gly Leu Lys Arg Arg 
             820



<210> 7624
<211> 1736
<212> DNA
<213> Rattus norvegicus
<308> S55427
<400> 7624

gggggaagc  agcaaccta  aggacgccc  cgagtttgt  cctgaggct  ctccgctct  60
agccggctg  ccctttgaa  tgaaagcac  gctccaccg  gcccgagcc  aactccagc  120
accatgctt  tactcttgt  ggggatcct  ttccttcac  tcgcggtgc  agtgttgct  180
ttcgtctcc  ccatcgtca  ccaatggct  gtgggcaat  gacacagga  tgatctctg  240
cagaactgt  ccacatccg  cttgggagc  gtccagcac  gctactcct  atctgtgag  300
gaatggctt  agtctgtcc  ggccaccat  atcctgtct  tcatcttca  cgtcctgtc  360
ctgttcctg  tcttctgcc  gctcttcac  ctcaccaaa  gcggccgct  ttacatcac  420
ggagtcttc  aaatccttg  tggtctgtg  gtgatgagt  cagcggcca  ctacacagt  480
agacacagt  agtggcatg  caacaacga  tactcctat  gctttgctt  catcctggc  540
tgggtggct  tcccgctgg  cctccttag  ggcatcatc  acgtgatcc  gcggaaacg  600
gaatgaggc  cccgacgca  catccgtct  ggctctgag  gtgcatagg  tacacaggg  660
gggaggaag  aaaccagaa  accaaacca  ccaacccaa  agagctagc  cccaaaccc  720
aacgcaagc  aaaccaaac  gaacacagt  gagtgggga  tgctgtcga  tgaagatgt  780
tataatatc  atggtttat  aaacctatt  ataacactt  ttacataca  gtacatagg  840
ttgtttgct  tttatgttg  ccgtcagcc  cgtgttgaa  cttaaacga  tctacatcc  900
aacactata  ccaagctca  tattttcgt  ttgtttcgt  tttttcatc  tttgttttg  960
tcagacata  aaaaaaaaa  aaaaatcca  gtggccccc  ttcatctga  agcagatcc  1020
tccctccca  tcaacctca  aggataacc  aagtgcggg  acaaacccc  gatggccag  1080
ggccttcac  ctatgggtg  cccagtgaa  ttagcagga  taatccgct  cccgaatca  1140
tgtgtgaag  cctaagcac  cacagacga  acgccctga  cagagccct  tgcgaaacc  1200
atagctggt  gctgcggaa  acttgaccc  gaaggcgga  tactggggc  catgtttaa  1260
tgagacgtc  gagacaagc  atctgtgaa  tggtgctat  gatttacca  tccttgtta  1320
tactaatca  ttaaaccac  cactggaaa  tcaattaac  gttttatga  ctacagcag  1380
acagagacc  gatacaaac  gttcgtaac  gctttcgta  atagctagg  tgttgttat  1440
actacaata  ataaatctc  aagccttcg  cactcccac  gttttctca  ggtcggagc  1500
tcaggacga  ggtctagac  cttgggact  gcaaattcc  tggctttct  ggtctagag  1560
gttctgtgc  tccaaggac  gtctagcga  gacttgtat  ggccaccaa  tgtagatgt  1620
tatacggtg  ccttctgat  ctaagactc  agacctttc  tggttttgc  ggctttttc  1680
gattttata  caactgtgt  gactaagat  cattaaaat  aacatcaga  taactc  1736



<210> 7625
<211> 160
<212> PRT
<213> Rattus norvegicus
<308> AAB25374
<400> 7625

Met Leu Leu Leu Leu Leu Gly Ile Leu Phe Leu His Ile Ala Val Leu 
  1               5                  10                  15
Val Leu Leu Phe Val Ser Thr Ile Val Ser Gln Trp Leu Val Gly Asn 
             20                  25                  30
Gly His Arg Thr Asp Leu Trp Gln Asn Cys Thr Thr Ser Ala Leu Gly 
         35                  40                  45
Ala Val Gln His Cys Tyr Ser Ser Ser Val Ser Glu Trp Leu Gln Ser 
     50                  55                  60
Val Gln Ala Thr Met Ile Leu Ser Val Ile Phe Ser Val Leu Ser Leu 
 65                  70                  75                  80
Phe Leu Phe Phe Cys Gln Leu Phe Thr Leu Thr Lys Gly Gly Arg Phe 
                 85                  90                  95
Tyr Ile Thr Gly Val Phe Gln Ile Leu Ala Gly Leu Cys Val Met Ser 
             100                105                110
Ala Ala Ala Ile Tyr Thr Val Arg His Ser Glu Trp His Val Asn Asn 
         115                120                125
Asp Tyr Ser Tyr Gly Phe Ala Tyr Ile Leu Ala Trp Val Ala Phe Pro 
     130                135                140
Leu Ala Leu Leu Ser Gly Ile Ile Tyr Val Ile Leu Arg Lys Arg Glu 
 145                150                155                160



<210> 7626
<211> 601
<212> DNA
<213> Homo sapiens
<308> S61788
<400> 7626

gcgctctcc  cgcaggcag  aactccgct  agcagaact  gccgccaga  tgctcctcc  60
gttgctgag  atcatcgtc  tccacgtcg  ggtgccggt  ctgctgttc  tctccacga  120
cgtcagcca  tggatcgtg  gcaatggac  cgcaactga  ctctggcag  actgtagca  180
ctcttcctc  ggaaatgtc  accactgtt  ctcatcatc  ccaaacgaa  ggctgcagt  240
tgtccaggc  accatgatc  tgtcgatca  cttcagcat  ctgtctctg  tcctgttct  300
ctgccaact  ttcaccctc  ccaaggggg  caggtttta  atcactgga  tcttccaaa  360
tcttgctgg  ctgtgcgtg  tgagtgctg  ggccatcta  acggtgagg  acccggagt  420
gcatctcaa  tcggattac  cctacggtt  cgcctacat  ctggcctgg  tggccttcc  480
cctggccct  ctcagcggt  tcatctatg  gatcttgcg  aaacgcgaa  gaggcgccc  540
gacggtctg  ctgaggctc  gagcgtaca  agggaaggg  ggaagggaa  acagaaagc  600
g  601



<210> 7627
<211> 160
<212> PRT
<213> Homo sapiens
<308> Q01453
<400> 7627

Met Leu Leu Leu Leu Leu Ser Ile Ile Val Leu His Val Ala Val Leu 
  1               5                  10                  15
Val Leu Leu Phe Val Ser Thr Ile Val Ser Gln Trp Ile Val Gly Asn 
             20                  25                  30
Gly His Ala Thr Asp Leu Trp Gln Asn Cys Ser Thr Ser Ser Ser Gly 
         35                  40                  45
Asn Val His His Cys Phe Ser Ser Ser Pro Asn Glu Trp Leu Gln Ser 
     50                  55                  60
Val Gln Ala Thr Met Ile Leu Ser Ile Ile Phe Ser Ile Leu Ser Leu 
 65                  70                  75                  80
Phe Leu Phe Phe Cys Gln Leu Phe Thr Leu Thr Lys Gly Gly Arg Phe 
                 85                  90                  95
Tyr Ile Thr Gly Ile Phe Gln Ile Leu Ala Gly Leu Cys Val Met Ser 
             100                105                110
Ala Ala Ala Ile Tyr Thr Val Arg His Pro Glu Trp His Leu Asn Ser 
         115                120                125
Asp Tyr Ser Tyr Gly Phe Ala Tyr Ile Leu Ala Trp Val Ala Phe Pro 
     130                135                140
Leu Ala Leu Leu Ser Gly Val Ile Tyr Val Ile Leu Arg Lys Arg Glu 
 145                150                155                160



<210> 7628
<211> 3208
<212> DNA
<213> Rattus norvegicus
<308> S56141
<400> 7628

gaattccgc  taagaatag  aaagtagta  agagagatt  ggatgatga  gtcattgaa  60
ctgtcaaag  cctcctgtc  aatgaagac  cagtggaag  tgtttctaa  aagagcgaa  120
taattgttg  tgttcaaga  gagaaagat  cagatgctg  agatggatc  gaagttgat  180
atgaaaggc  agcttggaa  agtaagctg  aatacatcc  ggcgcaagt  ggattttct  240
taggtctgg  gaatgtgtg  cggttccca  acctctgcc  aaagaatgg  ggtggtgca  300
atcttttgc  atatttaat  ctacttctg  tgataggaa  tccactctt  ttcttggaa  360
tttctgtgg  tcaaagaat  cggagaggc  gcatcgggg  ttggaatta  ataagccct  420
aactgggtg  gattggatt  gcaagctgt  tagtgtgct  ttttgtggc  ctctactac  480
atgtcatca  tggctggac  ttgttttac  tttctcagt  ttttcaaca  cctctccct  540
gggatcaat  ccccctggt  aaaaacgca  ctcatactt  tattgagcc  gaatgtgaa  600
aaagttctg  caccactta  tactggtac  gggaagcac  ggctatcag  agctccatc  660
ctgaaagtg  gggcttaaa  tggaagatg  ctggctgcc  gctggctgc  tgggtcatg  720
tttgtctgg  catgatcaa  ggcattcag  cctctggaa  aatcatgta  tttagttct  780
tgttcccct  cgtggtact  atatgcttc  taataagat  tctcctttt  aatggttca  840
ttgatggca  ccgacacat  ttcacccct  agcttgaaa  gatgctgga  cccaaggtt  900
ggagagagg  agcgactca  gtcttcttt  ccttgggtt  gggatttgg  ggagtcatc  960
cgttttcca  ttacaacaa  agagacaac  actgccact  cgacgctgt  ctcgtgtct  1020
ttatcaact  tttcacttc  gtcctggca  cactggtgg  gttcgcagt  ctggggttc  1080
aagccaata  cgtaaatga  aagtgcatt  cacaaaatt  tgagatgat  ttgaaactt  1140
tgaaaacgg  aaacgttag  tgggatgtc  ttccccgtc  catcaacct  tcagctgtc  1200
ctgcggaag  ttatcatgt  gtttacgac  tcattcaaa  agtgaagga  gaggagttt  1260
ctgttctcc  tctcaaagc  tgtcaaatt  aggatgagc  aaataaagc  gtgcagggc  1320
ctggcttgg  tttcattgc  tttacagag  ccatgacac  ttttcctgc  tctcccttc  1380
ggtcagtga  gtttttcct  atgctgata  atctcgggc  cggcagcat  tttggaacc  1440
ttgaaggaa  catcactcc  gttgtggac  cattcaaag  gaggaagga  atactcacc  1500
ttatctgtt  cctcctagc  ttttgtatc  gcttgatgt  tgtgcagcg  tctggaaat  1560
acttcgtta  aatgtttga  gattattct  ccacattgc  tctgttaat  gtggtcatc  1620
tggagaata  tgctgtaag  ttcgtttac  gcatagata  gtttctaga  gacctaaca  1680
acatgttag  atttgctcc  agcaaatat  actattaca  gtggaaata  atttctcct  1740
taatgctag  aacattgtt  atagctagc  ttgtgaata  gggattaag  cctccggga  1800
ataatgcat  gatcaagga  aaggcatcc  aagaatttc  gagctaccc  atgtggggg  1860
tggtggtct  tttctctct  atggtgctg  ctatacttc  tgtcccagt  gttttcgtc  1920
ttcgtcgct  caacctcat  gatgatagt  ctggtaact  ggcctctgt  acctataag  1980
gaggaagag  cctgaaaga  cccgtgaac  tagacggag  tgatgcaag  ctcattcac  2040
gaaagatac  aagtgaaat  tcgtctcca  attttggta  aaatatcta  cgaaaacag  2100
gtggttctc  gaccctgga  actgctccc  atggacgct  tgggattgg  tatttgatg  2160
cagatatgc  agatatgcc  gagtctgac  tgtagctga  tgaaagcaa  gggttgagc  2220
tggttcatt  ttatcaatg  gcattggtt  tactatgag  agcagtgag  ttcacttgt  2280
acaaggtga  ctcaggtgt  catagccgc  atctttaat  tcaacagtt  aagacagtt  2340
cagaagagc  atcctcagt  tacaattac  aagtaacaa  tgcagacaa  gcttacatt  2400
actggggtc  tttgccagg  tttttttaa  aagcacttt  acatacttt  aagtatttc  2460
atctcttaa  aaaaaggtg  tacctcagt  tctaatagt  tccggattt  atattattg  2520
cgatttgaa  aaaaatccc  gttatatct  acaattcat  attttgcct  cggagtaag  2580
tccagtatt  ccatgaaca  ttgtgtgtg  gcgggtgct  ctcagcaca  tgccatgag  2640
acgttctgt  gatagcctg  acttatctt  ggtagcatt  aaaccttag  cacttagtt  2700
gagaaaact  caaagtatt  tcttatatg  tagccgtct  gagcaatag  attaaagag  2760
aaaaaggca  tgatggtgg  tgagaggtt  agtccagat  tgatcgagg  tttcctgga  2820
tggccatat  ttttgtgta  aataggtgt  tgcaaatga  tgaagggac  ctcgagaat  2880
atgcagact  catttttct  atgccgtgt  cctaataaa  ctacttaat  tttattgtg  2940
ttttgagat  acttatagt  tatttatat  atatacttg  aatgtatag  gatgcgcat  3000
aggactctt  agtgctggt  tgaaaactt  aagcaagat  gcatctgat  tcatatgtt  3060
ctgttttgc  tcattttat  caaatacga  ttctttttt  taagtgatt  ttaaaactg  3120
atggcatta  attttaacc  acaaataaa  gaagtttan  aaaaaaaaa  aaaaaaaaa  3180
aaaaaaaaa  aaaaaaaaa  aggaattc  3208



<210> 7629
<211> 729
<212> PRT
<213> Rattus norvegicus
<308> AAA41729
<400> 7629

Met Pro Lys Asn Ser Lys Val Val Lys Arg Asp Leu Asp Asp Asp Val 
  1               5                  10                  15
Ile Glu Ser Val Lys Asp Leu Leu Ser Asn Glu Asp Ser Val Glu Asp 
             20                  25                  30
Val Ser Lys Lys Ser Glu Leu Ile Val Asp Val Gln Glu Glu Lys Asp 
         35                  40                  45
Thr Asp Ala Glu Asp Gly Ser Glu Val Asp Asp Glu Arg Pro Ala Trp 
     50                  55                  60
Asn Ser Lys Leu Gln Tyr Ile Leu Ala Gln Val Gly Phe Ser Val Gly 
 65                  70                  75                  80
Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gln Lys Asn Gly Gly 
                 85                  90                  95
Gly Ala Tyr Leu Leu Pro Tyr Leu Ile Leu Leu Leu Val Ile Gly Ile 
             100                105                110
Pro Leu Phe Phe Leu Glu Leu Ser Val Gly Gln Arg Ile Arg Arg Gly 
         115                120                125
Ser Ile Gly Val Trp Asn Tyr Ile Ser Pro Lys Leu Gly Gly Ile Gly 
     130                135                140
Phe Ala Ser Cys Val Val Cys Tyr Phe Val Ala Leu Tyr Tyr Asn Val 
 145                150                155                160
Ile Ile Gly Trp Thr Leu Phe Tyr Phe Ser Gln Ser Phe Gln Gln Pro 
                 165                170                175
Leu Pro Trp Asp Gln Cys Pro Leu Val Lys Asn Ala Ser His Thr Tyr 
             180                185                190
Ile Glu Pro Glu Cys Glu Lys Ser Ser Ala Thr Thr Tyr Tyr Trp Tyr 
         195                200                205
Arg Glu Ala Leu Ala Ile Ser Ser Ser Ile Ser Glu Ser Gly Gly Leu 
     210                215                220
Asn Trp Lys Met Thr Gly Cys Leu Leu Ala Ala Trp Val Met Val Cys 
 225                230                235                240
Leu Ala Met Ile Lys Gly Ile Gln Ser Ser Gly Lys Ile Met Tyr Phe 
                 245                250                255
Ser Ser Leu Phe Pro Tyr Val Val Leu Ile Cys Phe Leu Ile Arg Ser 
             260                265                270
Leu Leu Leu Asn Gly Ser Ile Asp Gly Ile Arg His Met Phe Thr Pro 
         275                280                285
Lys Leu Glu Met Met Leu Glu Pro Lys Val Trp Arg Glu Ala Ala Thr 
     290                295                300
Gln Val Phe Phe Ala Leu Gly Leu Gly Phe Gly Gly Val Ile Ala Phe 
 305                310                315                320
Ser Ser Tyr Asn Lys Arg Asp Asn Asn Cys His Phe Asp Ala Val Leu 
                 325                330                335
Val Ser Phe Ile Asn Phe Phe Thr Ser Val Leu Ala Thr Leu Val Val 
             340                345                350
Phe Ala Val Leu Gly Phe Lys Ala Asn Ile Val Asn Glu Lys Cys Ile 
         355                360                365
Ser Gln Asn Ser Glu Met Ile Leu Lys Leu Leu Lys Thr Gly Asn Val 
     370                375                380
Ser Trp Asp Val Ile Pro Arg His Ile Asn Leu Ser Ala Val Thr Ala 
 385                390                395                400
Glu Asp Tyr His Val Val Tyr Asp Ile Ile Gln Lys Val Lys Glu Glu 
                 405                410                415
Glu Phe Ala Val Leu His Leu Lys Ala Cys Gln Ile Glu Asp Glu Leu 
             420                425                430
Asn Lys Ala Val Gln Gly Thr Gly Leu Ala Phe Ile Ala Phe Thr Glu 
         435                440                445
Ala Met Thr His Phe Pro Ala Ser Pro Phe Trp Ser Val Met Phe Phe 
     450                455                460
Leu Met Leu Ile Asn Leu Gly Leu Gly Ser Met Phe Gly Thr Ile Glu 
 465                470                475                480
Gly Ile Ile Thr Pro Val Val Asp Thr Phe Lys Val Arg Lys Glu Ile 
                 485                490                495
Leu Thr Val Ile Cys Cys Leu Leu Ala Phe Cys Ile Gly Leu Met Phe 
             500                505                510
Val Gln Arg Ser Gly Asn Tyr Phe Val Thr Met Phe Asp Asp Tyr Ser 
         515                520                525
Ala Thr Leu Pro Leu Leu Ile Val Val Ile Leu Glu Asn Ile Ala Val 
     530                535                540
Ser Phe Val Tyr Gly Ile Asp Lys Phe Leu Glu Asp Leu Thr Asp Met 
 545                550                555                560
Leu Gly Phe Ala Pro Ser Lys Tyr Tyr Tyr Tyr Met Trp Lys Tyr Ile 
                 565                570                575
Ser Pro Leu Met Leu Val Thr Leu Leu Ile Ala Ser Ile Val Asn Met 
             580                585                590
Gly Leu Ser Pro Pro Gly Tyr Asn Ala Trp Ile Lys Glu Lys Ala Ser 
         595                600                605
Glu Glu Phe Leu Ser Tyr Pro Met Trp Gly Met Val Val Cys Phe Ser 
     610                615                620
Leu Met Val Leu Ala Ile Leu Pro Val Pro Val Val Phe Val Ile Arg 
 625                630                635                640
Arg Cys Asn Leu Ile Asp Asp Ser Ser Gly Asn Leu Ala Ser Val Thr 
                 645                650                655
Tyr Lys Arg Gly Arg Val Leu Lys Glu Pro Val Asn Leu Asp Gly Asp 
             660                665                670
Asp Ala Ser Leu Ile His Gly Lys Ile Pro Ser Glu Met Ser Ser Pro 
         675                680                685
Asn Phe Gly Lys Asn Ile Tyr Arg Lys Gln Ser Gly Ser Pro Thr Leu 
     690                695                700
Asp Thr Ala Pro Asn Gly Arg Tyr Gly Ile Gly Tyr Leu Met Ala Asp 
 705                710                715                720
Met Pro Asp Met Pro Glu Ser Asp Leu 
                 725



<210> 7630
<211> 2573
<212> DNA
<213> Rattus norvegicus
<308> S56508
<400> 7630

gccttccat  aagatgtgg  aacctcttt  cctgagcgc  acaggctct  gaaagagag  60
ctggttcta  caggatcaa  tccactcct  agtgcccgg  ggctgctgg  aagagattg  120
cctgtcact  ctggagaag  tgcagaccc  ggagatcct  aggatcctg  ggctgcccg  180
gctatcgga  ttgggccag  ttttccgca  cctctcagc  accaccctt  tgagtatgg  240
tgcactggc  gccatcctt  catactggc  cactcaccg  ccaaaggcc  tgcaaccac  300
atgcaacct  ctgatgcag  cggaagaag  agaggacag  ggtggagcc  ggcgatctg  360
gattgggga  tgcactcag  tgcttaccc  ctactatga  gatgcccgg  cgatgtacc  420
ggtgttccg  cgtgggctt  gcatctcag  gaatggacc  tgtcttggc  tccggaagc  480
agagcaacc  taccagtgg  tgtcctatc  agaggtggc  aaaagggct  aattcctgg  540
gtcaggact  ctccagcat  actgtaaag  gggcacaga  cagttcatt  gcgtttttg  600
acaaaatcg  ccagagtgg  tcattgctg  gctggcctg  tacacatat  ccatggtgg  660
ggtaccgct  tatgacaca  tgggcccag  gtctatccg  tacatcatc  atacagcgg  720
catctgcac  gtaatcgtg  ataagccgc  taaggctat  ctcctgcta  aacacgtgg  780
gaggaagga  actccgggc  tcaagctgg  catcctcat  gagccattt  acgatgccc  840
gagagagag  ggaaagaag  gcggggtgg  catcaagtc  atgcaggct  tagaggact  900
cggccaaga  aatcatcgt  tccccgtgc  cccacggcc  gatgacctc  ccattgtgt  960
tttcacgag  ggtacaaca  ggaacccca  aggtgcgat  ctcacccac  ggaacgtgg  1020
ggccgattt  tcgggcttt  tgaaagtca  agagagtca  tgggccccc  cttgtgcgg  1080
tgtacactt  tcctatttg  ctttagcac  catgtttga  cgaatggtg  agtctgttg  1140
ctactgcca  ggagggcgt  tgggcttct  ccagggaga  atccgcctc  tctcagacg  1200
catgaaagc  ctccgcccc  ccatcttcc  tgtggtccc  cggctgctg  atcggatgt  1260
tgacaagat  ttccaccag  cagacacct  actgaagcg  tggctcctg  agtttgcag  1320
aaagcgcaa  caggctgag  tccggagcg  aatcatcag  aacaatagt  tctgggatg  1380
actcttctt  aataagatt  aggccagtc  tggagggca  gtgagaatg  ttgttaccg  1440
agcagcccc  gcatcacca  cagtcctgg  attcctacg  gcagctctg  ggtgccagg  1500
ctatgaagg  tatgggcaa  ctgaatgca  agctgggtg  accttcaca  cgccagggg  1560
ctggacatc  gggcacgtg  gagcccctc  gccctgcaa  cacatcaag  tggtcgacg  1620
agaggaact  aactactgg  ccagcaaag  agaaggaga  atctgtgtg  aaggaccaa  1680
tgtgttcaa  ggctactta  aagacgagg  caggacaaa  gaggccctg  acagtgacg  1740
ctggcttca  acgggagac  ttggaaaat  gctgccgga  ggaacgctt  aaatcatcg  1800
tcggaaaaa  gacatattt  aacttgctc  gggggaata  gttgcgccc  agaagattg  1860
gaacatcta  atccgaagt  agcctgtgg  gcaaatcta  gtccatggg  acagcttaa  1920
ggcctttct  gttggcatt  ttgtgcctg  ccctgaagt  atgccttgc  gggctcaga  1980
gaaaggaat  gaagggaac  accaggaac  ctgcaaaag  aaggaattg  agaaagcca  2040
tctggatga  atggtgatg  tggggaaag  aagtggact  cattctttt  aacaggtta  2100
agccattta  atccattgt  acatgttct  agttcaaaa  ggcttgctg  caccaacac  2160
aaaggctaa  aggcccgag  tgagagagt  cttcaaaaa  caaatagaa  agctgtact  2220
aatctccat  tgaagctca  ggaggccct  ctcagccca  caaagtttg  agcaatatt  2280
taattattc  tgagagaaa  ggagtcaga  tgccacagc  cagagtgaa  gagcacctg  2340
ttttttttt  tttttgcaa  tgagccttt  ctgacctga  aagtctcta  caatatttt  2400
tctaccatc  ccaagtacc  ctttatttt  attaaatga  attgtagca  gctgctaaa  2460
aaaattatt  caaacggta  tgtaaaaac  aatcaagac  tttctcaag  actgtgtac  2520
actaaagta  tatattcgc  atgttcaca  aattccatt  aacataaaa  aaa  2573



<210> 7631
<211> 697
<212> PRT
<213> Rattus norvegicus
<308> AAB19809
<400> 7631

Met Gln Thr Gln Glu Ile Leu Arg Ile Leu Arg Leu Pro Glu Leu Ser 
  1               5                  10                  15
Asp Leu Gly Gln Phe Phe Arg Ser Leu Ser Ala Thr Thr Leu Val Ser 
             20                  25                  30
Met Gly Ala Leu Ala Ala Ile Leu Ala Tyr Trp Leu Thr His Arg Pro 
         35                  40                  45
Lys Ala Leu Gln Pro Pro Cys Asn Leu Leu Met Gln Ser Glu Glu Val 
     50                  55                  60
Glu Asp Ser Gly Gly Ala Arg Arg Ser Val Ile Gly Asp Cys Thr Gln 
 65                  70                  75                  80
Leu Leu Thr His Tyr Tyr Asp Asp Ala Arg Thr Met Tyr Gln Val Phe 
                 85                  90                  95
Arg Arg Gly Leu Ser Ile Ser Gly Asn Gly Pro Cys Leu Gly Phe Arg 
             100                105                110
Lys Pro Glu Gln Pro Tyr Gln Trp Leu Ser Tyr Gln Glu Val Ala Lys 
         115                120                125
Arg Ala Glu Phe Leu Gly Ser Gly Leu Leu Gln His Asp Cys Lys Val 
     130                135                140
Gly Thr Glu Gln Phe Ile Gly Val Phe Ala Gln Asn Arg Pro Glu Trp 
 145                150                155                160
Ile Ile Ala Glu Leu Ala Cys Tyr Thr Tyr Ser Met Val Val Val Pro 
                 165                170                175
Leu Tyr Asp Thr Leu Gly Pro Gly Ser Ile Arg Tyr Ile Ile Asn Thr 
             180                185                190
Ala Asp Ile Cys Thr Val Ile Val Asp Lys Pro His Lys Ala Ile Leu 
         195                200                205
Leu Leu Glu His Val Glu Arg Lys Glu Thr Pro Gly Leu Lys Leu Val 
     210                215                220
Ile Leu Met Glu Pro Phe Asp Asp Ala Leu Arg Glu Arg Gly Lys Lys 
 225                230                235                240
Cys Gly Val Asp Ile Lys Ser Met Gln Ala Ile Glu Asp Ser Gly Gln 
                 245                250                255
Glu Asn His Arg Val Pro Val Pro Pro Arg Pro Asp Asp Leu Ser Ile 
             260                265                270
Val Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Leu 
         275                280                285
Thr His Gly Asn Val Val Ala Asp Phe Ser Gly Phe Leu Lys Val Thr 
     290                295                300
Glu Ser Gln Trp Ala Pro Thr Cys Ala Asp Val His Phe Ser Tyr Leu 
 305                310                315                320
Pro Leu Ala His Met Phe Glu Arg Met Val Gln Ser Val Val Tyr Cys 
                 325                330                335
His Gly Gly Arg Val Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Ser 
             340                345                350
Asp Asp Met Lys Ala Leu Arg Pro Thr Ile Phe Pro Val Val Pro Arg 
         355                360                365
Leu Leu Asn Arg Met Tyr Asp Lys Ile Phe His Gln Ala Asp Thr Ser 
     370                375                380
Leu Lys Arg Trp Leu Leu Glu Phe Ala Ala Lys Arg Lys Gln Ala Glu 
 385                390                395                400
Val Arg Ser Gly Ile Ile Arg Asn Asn Ser Ile Trp Asp Glu Leu Phe 
                 405                410                415
Phe Asn Lys Ile Gln Ala Ser Leu Gly Gly His Val Arg Met Ile Val 
             420                425                430
Thr Gly Ala Ala Pro Ala Ser Pro Thr Val Leu Gly Phe Leu Arg Ala 
         435                440                445
Ala Leu Gly Cys Gln Val Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr 
     450                455                460
Ala Gly Cys Thr Phe Thr Thr Pro Gly Asp Trp Thr Ser Gly His Val 
 465                470                475                480
Gly Ala Pro Leu Pro Cys Asn His Ile Lys Leu Val Asp Ala Glu Glu 
                 485                490                495
Leu Asn Tyr Trp Thr Ser Lys Gly Glu Gly Glu Ile Cys Val Lys Gly 
             500                505                510
Pro Asn Val Phe Lys Gly Tyr Leu Lys Asp Glu Asp Arg Thr Lys Glu 
         515                520                525
Ala Leu Asp Ser Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys Trp 
     530                535                540
Leu Pro Glu Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe 
 545                550                555                560
Lys Leu Ala Gln Gly Glu Tyr Val Ala Pro Glu Lys Ile Glu Asn Ile 
                 565                570                575
Tyr Ile Arg Ser Glu Pro Val Ala Gln Ile Tyr Val His Gly Asp Ser 
             580                585                590
Leu Lys Ala Phe Leu Val Gly Ile Val Val Pro Asp Pro Glu Val Met 
         595                600                605
Pro Cys Trp Ala Gln Lys Lys Gly Ile Glu Gly Asn Tyr Gln Glu Leu 
     610                615                620
Cys Lys Ser Lys Glu Leu Lys Lys Ala Ile Leu Asp Asp Met Val Met 
 625                630                635                640
Leu Gly Lys Glu Ser Gly Leu His Ser Phe Glu Gln Val Lys Ala Ile 
                 645                650                655
Tyr Ile His Cys Asp Met Phe Ser Val Gln Asn Gly Leu Leu Thr Pro 
             660                665                670
Thr Leu Lys Ala Lys Arg Pro Glu Leu Arg Glu Tyr Phe Lys Lys Gln 
         675                680                685
Ile Glu Glu Leu Tyr Ser Ile Ser Met 
     690                695



<210> 7632
<211> 603
<212> DNA
<213> Rattus norvegicus
<308> S56937
<400> 7632

gcatctgtg  ggctgttcc  aggggactt  gtgtttgac  acccgaggc  catcatgcc  60
aatatggtc  tcattggag  cataaactg  gtcatcaag  agcccctct  tcaggaatt  120
gaagcctat  tcaacgcct  cggagaaca  ggcatcgtg  ttttctctt  gggatccat  180
gtctcagag  ttccagaga  gaaagcgat  gaaatcgct  aggctttgg  cagaattcc  240
cagacgctc  tgtggcgct  caccggaac  agaccatcg  accttgcaa  gaacactat  300
cttgtcaaa  ggctacccc  aaacgatct  cttggtcat  caaaggctc  ggcgttcat  360
acacactcc  gttcccatg  tatttatga  ggaatatgc  atggggttc  aatggtgat  420
atgcccttg  ttggtgatc  gatggacaa  gccaagcgc  tggaaactc  gggagctgg  480
gtgaccctg  atgtcctgg  aatgactgc  gatgatttg  aaaacgccc  taaaactgt  540
atcaataac  agagttaca  ggagaacat  atgcgcctc  ccagccttc  caaggaccg  600
cct  603



<210> 7633
<211> 533
<212> PRT
<213> Rattus norvegicus
<308> AAA42312
<400> 7633

Met Asp Thr Gly Leu Cys Ala Pro Leu Arg Gly Leu Ser Gly Leu Leu 
  1               5                  10                  15
Leu Leu Leu Cys Ala Leu Pro Trp Ala Glu Gly Gly Lys Val Leu Val 
             20                  25                  30
Phe Pro Met Glu Gly Ser His Trp Leu Ser Met Arg Asp Val Val Arg 
         35                  40                  45
Glu Leu His Ala Arg Gly His Gln Ala Val Val Leu Ala Pro Glu Val 
     50                  55                  60
Thr Val His Met Lys Gly Glu Asp Phe Phe Thr Leu Gln Thr Tyr Ala 
 65                  70                  75                  80
Phe Pro Tyr Thr Lys Glu Glu Tyr Gln Arg Glu Ile Leu Gly Asn Ala 
                 85                  90                  95
Lys Lys Gly Phe Glu Pro Gln His Phe Val Lys Thr Phe Phe Glu Thr 
             100                105                110
Met Ala Ser Ile Lys Lys Phe Phe Asp Leu Tyr Ala Asn Ser Cys Ala 
         115                120                125
Ala Leu Leu His Asn Lys Thr Leu Ile Gln Gln Leu Asn Ser Ser Ser 
     130                135                140
Phe Asp Val Val Leu Thr Asp Pro Val Phe Pro Cys Gly Ala Leu Leu 
 145                150                155                160
Ala Lys Tyr Leu Gln Ile Pro Ala Val Phe Phe Leu Arg Ser Val Pro 
                 165                170                175
Cys Gly Ile Asp Tyr Glu Ala Thr Gln Cys Pro Lys Pro Ser Ser Tyr 
             180                185                190
Ile Pro Asn Leu Leu Thr Met Leu Ser Asp His Met Thr Phe Leu Gln 
         195                200                205
Arg Val Lys Asn Met Leu Tyr Pro Leu Thr Leu Lys Tyr Ile Cys His 
     210                215                220
Leu Ser Ile Thr Pro Tyr Glu Ser Leu Ala Ser Glu Leu Leu Gln Arg 
 225                230                235                240
Glu Met Ser Leu Val Glu Val Leu Ser His Ala Ser Val Trp Leu Phe 
                 245                250                255
Arg Gly Asp Phe Val Phe Asp Tyr Pro Arg Pro Ile Met Pro Asn Met 
             260                265                270
Val Phe Ile Gly Gly Ile Asn Cys Val Ile Lys Lys Pro Leu Ser Gln 
         275                280                285
Glu Phe Glu Ala Tyr Val Asn Ala Ser Gly Glu His Gly Ile Val Val 
     290                295                300
Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met 
 305                310                315                320
Glu Ile Ala Glu Ala Leu Gly Arg Ile Pro Gln Thr Leu Leu Trp Arg 
                 325                330                335
Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Lys Asn Thr Ile Leu Val 
             340                345                350
Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Lys Ala Arg Ala 
         355                360                365
Phe Ile Thr His Ser Gly Ser His Gly Ile Tyr Glu Gly Ile Cys Asn 
     370                375                380
Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn 
 385                390                395                400
Ala Lys Arg Met Glu Thr Arg Gly Ala Gly Val Thr Leu Asn Val Leu 
                 405                410                415
Glu Met Thr Ala Asp Asp Leu Glu Asn Ala Leu Lys Thr Val Ile Asn 
             420                425                430
Asn Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys 
         435                440                445
Asp Arg Pro Ile Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Tyr 
     450                455                460
Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp 
 465                470                475                480
Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu 
                 485                490                495
Ala Ile Val Leu Thr Val Val Phe Ile Val Tyr Lys Ser Cys Ala Tyr 
             500                505                510
Gly Cys Arg Lys Cys Phe Gly Gly Lys Gly Arg Val Lys Lys Ser His 
         515                520                525
Lys Ser Lys Thr His 
     530



<210> 7634
<211> 1605
<212> DNA
<213> Homo sapiens
<308> NM_019093
<400> 7634

atggccaca  gactccagg  tcccctgcc  tggctggcc  caggactgc  gcttctcct  60
agtgtccag  cctgggctg  gagtggaaa  gtgttggtg  tgcccattg  tggcagcca  120
tggctcagc  tgcgggagg  cttgcggga  ctccatgcc  gaggccacc  ggcagtggt  180
ctcacccca  aggtgaata  gcacatcaa  gaagagaac  ttttcaccc  gacaaccta  240
gccatttcg  ggacccagg  tgaatttga  cgccatgtg  tgggccaca  tcaactgta  300
tttgaaaca  aacattttc  gaagaaatt  ttcagaagt  tggcaatgt  gaacaatat  360
tctttggtc  atcataggt  ttgtgtgga  ctactacat  atgaggccc  gatcaggca  420
ctgaatgct  cttcctttg  tgtggtttt  acagacccc  ttaacctct  cgcggcagt  480
ctggctaag  acctgtcga  tcctactgt  ttttttttg  ggaacattc  atgtgattt  540
gactttaag  gcacacagt  tccaaaccc  tcctcctat  ttcctagat  actaacaac  600
aattcagac  acatgacat  catgcaaag  gtcaagaac  tgctctacc  tctggccct  660
tcctacatt  gccatgctt  ttctgctcc  tatgcaagc  ttgcctctg  gctttttca  720
agagaggtg  cagtggtgg  tattctcag  catgcatct  tgtggctgt  ccgagggga  780
tttgtgatg  actacccca  gccaatcat  cccaacatg  tcttcattg  gggcatcaa  840
tgtgccaac  ggaagccac  atctcagga  tttgaagcc  acattaatg  ttctggaga  900
catggaatt  tggttttct  tttgggatc  atggtctca  aaattccag  gaagaaagc  960
atggcaatt  ctgatgctt  gggcaaaat  cctcagaca  tcctgtggc  gtacactgg  1020
acccgacca  cgaatcttg  gaacaacac  atacttgtt  agtggctac  ccaaaacga  1080
ctgcttggt  acccgatga  ccgtgcctt  atcacccat  ctggttccc  tggtgttta  1140
gaaagcata  gcaatggcg  tcccatggt  atgatgccc  tgtttggtg  tcagatgga  1200
aatgcaaag  gcatggaga  taagggagc  ggagtgacc  tgaatgttc  ggaaatgac  1260
tctgaagat  tagaaaatg  tctaaaagc  gtcatcaat  acaaaagtt  caaggagaa  1320
atcatgcgc  tctccagcc  tcacaagga  cgcccggtg  agccgctgg  cctggccgt  1380
ttctgggtg  agtttgtga  gaggcacaa  ggcgcgcca  acctgcgcc  cgcagccca  1440
gacctcacc  ggtaccagt  ccattcctt  gacgtgatt  gtttcctct  ggccgtcgt  1500
ctgacagtg  ccttcatca  ctttaaatg  tgtgcttat  gctaccgga  atgcttggg  1560
aaaaaaggg  gagttaaga  agcccacaa  tccaagacc  attga  1605



<210> 7635
<211> 534
<212> PRT
<213> Homo sapiens
<308> NP_061966
<400> 7635

Met Ala Thr Gly Leu Gln Val Pro Leu Pro Trp Leu Ala Thr Gly Leu 
  1               5                  10                  15
Leu Leu Leu Leu Ser Val Gln Pro Trp Ala Glu Ser Gly Lys Val Leu 
             20                  25                  30
Val Val Pro Ile Asp Gly Ser His Trp Leu Ser Met Arg Glu Val Leu 
         35                  40                  45
Arg Glu Leu His Ala Arg Gly His Gln Ala Val Val Leu Thr Pro Glu 
     50                  55                  60
Val Asn Met His Ile Lys Glu Glu Asn Phe Phe Thr Leu Thr Thr Tyr 
 65                  70                  75                  80
Ala Ile Ser Trp Thr Gln Asp Glu Phe Asp Arg His Val Leu Gly His 
                 85                  90                  95
Thr Gln Leu Tyr Phe Glu Thr Glu His Phe Leu Lys Lys Phe Phe Arg 
             100                105                110
Ser Met Ala Met Leu Asn Asn Met Ser Leu Val Tyr His Arg Ser Cys 
         115                120                125
Val Glu Leu Leu His Asn Glu Ala Leu Ile Arg His Leu Asn Ala Thr 
     130                135                140
Ser Phe Asp Val Val Leu Thr Asp Pro Val Asn Leu Cys Ala Ala Val 
 145                150                155                160
Leu Ala Lys Tyr Leu Ser Ile Pro Thr Val Phe Phe Leu Arg Asn Ile 
                 165                170                175
Pro Cys Asp Leu Asp Phe Lys Gly Thr Gln Cys Pro Asn Pro Ser Ser 
             180                185                190
Tyr Ile Pro Arg Leu Leu Thr Thr Asn Ser Asp His Met Thr Phe Met 
         195                200                205
Gln Arg Val Lys Asn Met Leu Tyr Pro Leu Ala Leu Ser Tyr Ile Cys 
     210                215                220
His Ala Phe Ser Ala Pro Tyr Ala Ser Leu Ala Ser Glu Leu Phe Gln 
 225                230                235                240
Arg Glu Val Ser Val Val Asp Ile Leu Ser His Ala Ser Val Trp Leu 
                 245                250                255
Phe Arg Gly Asp Phe Val Met Asp Tyr Pro Arg Pro Ile Met Pro Asn 
             260                265                270
Met Val Phe Ile Gly Gly Ile Asn Cys Ala Asn Arg Lys Pro Leu Ser 
         275                280                285
Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val 
     290                295                300
Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala 
 305                310                315                320
Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp 
                 325                330                335
Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu 
             340                345                350
Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg 
         355                360                365
Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys 
     370                375                380
Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp 
 385                390                395                400
Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val 
                 405                410                415
Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile 
             420                425                430
Asn Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His 
         435                440                445
Lys Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu 
     450                455                460
Phe Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His 
 465                470                475                480
Asp Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu 
                 485                490                495
Leu Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala 
             500                505                510
Tyr Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala 
         515                520                525
His Lys Ser Lys Thr His 
     530



<210> 7636
<211> 603
<212> DNA
<213> Rattus norvegicus
<308> S58644
<400> 7636

ttcttttcc  gtgcctggt  cttgggcgt  ctttgctct  gccttggcg  gtgtctctg  60
ggtgtttgc  tgtgcctcg  cggtttctt  ggggtcttt  gtttctgct  ttctgtctt  120
tgctcgtgc  gggccttgg  tgggctgtt  tgctgcgtc  gtggccgtt  cgtctgtgg  180
ctgtgcctg  gctctgtgc  tggtgcctt  ggggtgtcg  gtgtgttgt  cccttcctg  240
cctgttgct  gctgctcct  gtgtgtctg  gtggtttgc  cgctgcttc  cctggggtt  300
cctgtcttc  tgtcctgcc  cctcctgtg  tttgttgtg  tgttctcgt  ggttgtctg  360
ttcgtcttt  tcgtcctgg  tgctgtgct  tgcttcttc  tttctgctt  ggtctgcgt  420
ttgttgttc  gcttctctg  tctgccctt  ggtttgtct  tcttgtccg  cctctgggt  480
cctgtgtgt  gttgtgccc  ctttgcctt  tccttcctg  tggctgtgg  tggctgctt  540
ctcctggtt  gtttggctc  cctggcttt  tggtttctt  tcgtctcct  cctcgtccg  600
tgt  603



<210> 7637
<211> 200
<212> PRT
<213> Rattus norvegicus
<308> AAB26278
<400> 7637

Leu Phe Leu Cys Leu Val Leu Gly Arg Pro Leu Leu Trp Pro Trp Arg 
  1               5                  10                  15
Val Ser Leu Arg Cys Leu Leu Val Pro Arg Arg Phe Leu Trp Gly Leu 
             20                  25                  30
Leu Phe Leu Leu Phe Cys Leu Leu Leu Val Leu Gly Leu Gly Trp Ala 
         35                  40                  45
Val Leu Leu Arg Pro Trp Pro Leu Arg Leu Trp Ala Val Pro Val Leu 
     50                  55                  60
Cys Ala Trp Cys Leu Trp Gly Val Val Cys Val Val Pro Phe Leu Pro 
 65                  70                  75                  80
Cys Cys Leu Leu Leu Leu Val Cys Leu Cys Gly Leu Leu Ala Ala Ser 
                 85                  90                  95
Pro Gly Val Ser Cys Leu Pro Val Leu Pro Pro Pro Val Leu Cys Cys 
             100                105                110
Gly Val Leu Val Gly Cys Leu Leu Arg Leu Cys Arg Pro Gly Cys Cys 
         115                120                125
Ala Leu Leu Leu Leu Phe Cys Phe Gly Leu Arg Phe Val Val Leu Leu 
     130                135                140
Leu Cys Ser Ala Leu Trp Phe Val Phe Leu Val Arg Pro Leu Gly Ala 
 145                150                155                160
Cys Val Trp Leu Cys Pro Leu Cys Leu Val Leu Pro Ala Gly Cys Gly 
                 165                170                175
Trp Leu Leu Pro Pro Gly Trp Phe Gly Ser Pro Gly Phe Leu Val Ser 
             180                185                190
Ser Arg Leu Leu Pro Arg Pro Leu 
         195                200



<210> 7638
<211> 2256
<212> DNA
<213> Rattus norvegicus
<308> S59525
<400> 7638

aagagactc  actcttgaa  cccgtcctt  gagaaatat  gctaacaat  cgtctcttg  60
gcaggacca  aatcactgc  cagccatca  caacagcat  cccctgaca  agggcaagc  120
cccgactct  accttatct  gaaagatcc  agtgacggt  actttcttc  ttttcctac  180
ctctactgc  ttcaatgcc  ctttcttgg  aaagctgca  aggtggacc  agaagagga  240
gaaaggaaa  aagctctca  ggatgaagg  gcttttaaa  catttgacc  tagccaacc  300
ccttgagac  ctaatcgtc  tgccgctgg  tgggatgtg  aacatcact  ttcagtggt  360
tgctggaga  ttcctttgc  aagttctca  ctatctgaa  ctcttctct  tgtatgccc  420
agccttcat  atggtggtg  ttagcctgg  tcgctccct  gccgtcact  agcccttag  480
tgtccaaag  aagagcaag  ttgaacggt  tatgaccag  ctggcctgg  ttctcagca  540
tgtctttgc  ggaccacag  tatatatct  caggatgat  tacctagtc  acggctctg  600
gccagcagt  ttctcgcaa  gtgtgaccc  ctgcagctt  ccgcaatgg  ggcatgaag  660
cttctacaa  tttttcacc  tcagctgcc  gttcatcat  cctcttctc  tcatgctaa  720
ctgcaatgc  aaaatcatc  tcgccctca  acgagtcct  catcaggac  cacgcaaac  780
acagctgaa  caatccaag  ataatatcc  aagagcacg  ctgagaact  taaagatga  840
agtggcatt  ggcacctcc  ttgtcatct  ctggactcc  tactacgtc  taggaatct  900
gtactggtt  gatccggaa  tgttaaaca  ggtgtcaga  ccagtcaat  acttcttct  960
tctctttgg  tttctaaac  cgtgcttcg  cccacttat  tatgggtat  tctctttgt  1020
attgggaga  tacccaagc  cttgtgctg  aacccatat  cgggataac  tatgtcacc  1080
gttgagaat  agctcaaag  ttgcaacat  cctatgtgc  agcaaggca  ggtttgggc  1140
caggttagc  gccttgtcc  tatacagag  ttgttgtta  cgcttcgga  gaccttcca  1200
aataactga  atctgtcct  aatcataag  ttctaaact  gcctcagcc  tgtctcatg  1260
tttattgca  cccatttgg  attctttac  tcctcctta  ataataatg  atagatact  1320
taaatgact  catcctaag  taaaaagta  caaaaagta  gaccgggaa  gcccaacat  1380
ttcacaaca  cagcttagt  tggggagtt  gtttttttt  ctcaaaggg  gctgagcat  1440
tataacacc  catcccaac  cctagagcc  acagagagc  gaatcgctg  ccatagatc  1500
tcagcaaaa  cagatgctg  tccaagacc  aaagcccag  gacagaagg  tccctgtcc  1560
gaggttagc  ggaaatact  gctgacact  tcccagcct  aggcacaga  atattacgc  1620
ccctcactg  ccataggtc  gcagcagta  cagctgatg  tatctatcc  agcctagag  1680
acagacaga  gagaatcac  gtccatggg  caaatttta  ctgcaatga  tgaaagact  1740
aattttcta  tttacttta  aagcctttc  gattcttat  cagcaacaa  tccaccagc  1800
caccaggat  atttacatg  tacaaatta  tcccattta  atgctacat  gcgacacat  1860
cctacatag  gggggtatt  aaaagggat  ggttttttt  catgggctg  tagaatatt  1920
cacagacta  acaacatgt  gggtttatg  caactgact  ccatgaata  tgttttaat  1980
taattcaga  aatgcctat  ataattatc  tgcaagcat  atatacaat  cactttaac  2040
atatggtgg  acgtttgtc  atcttatct  gccgagtca  gccccacag  taaatgagg  2100
aagtcaata  aacagtaag  aaatatata  acaccaaga  gggctttga  gtattaaag  2160
agctcaagg  aggaagcca  acaatttcc  ctatataga  caacagcac  gaatattag  2220
gaggagaat  ataaaactg  acatgtgaa  aaaaaa  2256



<210> 7639
<211> 327
<212> PRT
<213> Rattus norvegicus
<308> AAB26420
<400> 7639

Met Ala Asn Asn Ala Ser Leu Glu Gln Asp Gln Asn His Cys Ser Ala 
  1               5                  10                  15
Ile Asn Asn Ser Ile Pro Leu Thr Gln Gly Lys Leu Pro Thr Leu Thr 
             20                  25                  30
Leu Ser Gly Lys Ile Arg Val Thr Val Thr Phe Phe Leu Phe Leu Leu 
         35                  40                  45
Ser Thr Ala Phe Asn Ala Ser Phe Leu Val Lys Leu Gln Arg Trp Thr 
     50                  55                  60
Gln Lys Arg Lys Lys Gly Lys Lys Leu Ser Arg Met Lys Val Leu Leu 
 65                  70                  75                  80
Lys His Leu Thr Leu Ala Asn Leu Leu Glu Thr Leu Ile Val Met Pro 
                 85                  90                  95
Leu Asp Gly Met Trp Asn Ile Thr Val Gln Trp Tyr Ala Gly Glu Phe 
             100                105                110
Leu Cys Lys Val Leu Ser Tyr Leu Lys Leu Phe Ser Met Tyr Ala Pro 
         115                120                125
Ala Phe Met Met Val Val Ile Ser Leu Asp Arg Ser Leu Ala Val Thr 
     130                135                140
Gln Pro Leu Ala Val Gln Ser Lys Ser Lys Leu Glu Arg Ser Met Thr 
 145                150                155                160
Ser Leu Ala Trp Ile Leu Ser Ile Val Phe Ala Gly Pro Gln Leu Tyr 
                 165                170                175
Ile Phe Arg Met Ile Tyr Leu Ala Asp Gly Ser Gly Pro Ala Val Phe 
             180                185                190
Ser Gln Cys Val Thr His Cys Ser Phe Pro Gln Trp Trp His Glu Ala 
         195                200                205
Phe Tyr Asn Phe Phe Thr Phe Ser Cys Leu Phe Ile Ile Pro Leu Leu 
     210                215                220
Ile Met Leu Ile Cys Asn Ala Lys Ile Ile Phe Ala Leu Thr Arg Val 
 225                230                235                240
Leu His Gln Asp Pro Arg Lys Leu Gln Leu Asn Gln Ser Lys Asn Asn 
                 245                250                255
Ile Pro Arg Ala Arg Leu Arg Thr Leu Lys Met Thr Val Ala Phe Gly 
             260                265                270
Thr Ser Phe Val Ile Cys Trp Thr Pro Tyr Tyr Val Leu Gly Ile Trp 
         275                280                285
Tyr Trp Phe Asp Pro Glu Met Leu Asn Arg Val Ser Glu Pro Val Asn 
     290                295                300
His Phe Phe Phe Leu Phe Ala Phe Leu Asn Pro Cys Phe Asp Pro Leu 
 305                310                315                320
Ile Tyr Gly Tyr Phe Ser Leu 
                 325



<210> 7640
<211> 2735
<212> DNA
<213> Homo sapiens
<308> NM_000406
<400> 7640

ttggttgct  gtccactta  aaacacttt  catatttgt  tgtctttcc  atggttatc  60
tgttttgtt  atttcaggc  tatggccct  atcagatta  ctgacatga  gtatatgca  120
agccttttg  gttcttcag  aaaataaat  atcttattc  agactgatt  cttataagg  180
acttattat  gctaatata  taggcacaa  tttttttgt  attctccta  atgagtcag  240
acttagttt  gatgtaggt  aaaatttta  ggtcacaaa  ctcaggtgt  agaaaatct  300
tttccttga  actctatat  aatagagga  ataaatatt  caagtctgg  agtagtgag  360
gaagctggt  attctggac  tatagtgac  gtcaaaaag  agctcaggt  caggactgg  420
ctaagctgc  caagattca  gagacagcc  gtacacaga  aagctgagg  aataataca  480
atatatcta  aacacttat  taaccttct  tggtaacaa  ctccttaaa  gggctggat  540
atgttgtgt  cacttttta  caccagcaa  ggctaagat  atgtatata  taaatattt  600
gtaaccatt  attaaataa  taaatattt  agacagaat  aacaagtat  ataaatgaa  660
caataagaa  gcaccatct  agtcaaaat  gccactttt  tccttaaca  tgtacctgc  720
ttggctgct  cagaagcaa  cttgttggc  ttagacaaa  caagctggt  atttaataa  780
ttccaatgt  agtcttacc  gtattgatg  ataactatc  agcactcac  atgaaagtt  840
aagaagcaa  acagaaaaa  ttcctaagt  gtcccaatt  gaaatgatc  gataaccta  900
aaaagaaca  attcatatt  tactaacat  aacacatat  aatgcactt  cagcagtta  960
acagtattc  cttcaataa  tagtttcct  atgcattaa  gtgtaataa  agcaactac  1020
atatttaga  aattataaa  accaaggca  taatttaaa  actgattaa  cgttttact  1080
taacttaag  atggattgg  tcagtaaga  tgattaata  atttgaatg  agtcagttg  1140
attgattct  atttaaagt  ttaatttgt  gtagaataa  tttaagtga  tatatttgt  1200
cagtgttcg  gtgctcaac  gtgtgtttg  aaaggaaaa  aaagaatgt  ttgagaatg  1260
gttaattcc  taagacaat  gattttaat  ggatctgtt  ttttcattt  tcttcatta  1320
cattataca  ctgtatgtt  gacagaaca  taacactaa  tagttttta  aaagtgttt  1380
ttgaagtta  ttaaatcat  atatcatga  tgacttttg  attcaaaat  aggctgtga  1440
tatccttct  cacttagga  gagtgttgt  aaagccaga  catctgctg  ggtgctaca  1500
ttacatgtg  ccctcagaa  gcgtttggc  tgctctgtt  tagcactct  ttggattac  1560
aatacacaa  acaagttaa  ctttgatct  tcacattaa  tatctcagg  acaaaattt  1620
acatacgtc  aaacctgtg  cgtttccat  taaagaagg  agaaataaa  catggactt  1680
agattcggt  acaataaaa  atcagatgc  ccagagaca  aaggcttga  gctctgtcc  1740
gggaaaata  ggcaaacag  gcctctcct  aacagaatc  aaatcactg  tcagccatc  1800
acaacagca  cccactgat  cagggcaac  tccccactc  gaccttgtc  ggaaagatc  1860
gagtgacgg  tactttctt  ctttttctg  tctctgcga  ctttaatgc  tctttcttg  1920
tgaaacttc  gaagtggac  cagaagaaa  agaaaggga  aaagctctc  agaatgaag  1980
tgctcttaa  acatctgac  ttagccaac  tgttggaga  tctgattgt  atgccactg  2040
atgggatgt  gaacattac  gtccaatgg  atgctggag  gttactctg  aaagttctc  2100
gttatctaa  gcttttctc  atgtatgcc  cagccttca  gatggtggt  atcagcctg  2160
accgctccc  ggctatcac  aggccccta  ctttgaaaa  caacagcaa  gtcggacag  2220
ccatggttg  cctggcctg  atcctcagt  gtgtctttg  aggaccaca  ttatacatc  2280
tcaggatga  tcatctagc  gacagctct  gacagacaa  agttttctc  caatgtgta  2340
cacactgca  tttttcaca  tggtggcat  aagcatttt  taacttttt  accttcagc  2400
gcctcttca  catccctct  ttcatcatg  tgatctgca  tgcaaaaat  atcttcacc  2460
tgacacggg  ccttcatca  gacccccac  aactacaac  gaatcagtc  aagaacaat  2520
taccaagag  acggctgaa  actctaaaa  tgacggttg  atttgccac  tcatttact  2580
tctgctgga  tccctacta  gtcctagga  tttggtatt  gtttgatcc  gaaatgtta  2640
acaggttgt  agacccagt  aatcacttc  tctttctct  tgccttttt  aacccatgc  2700
ttgatccac  tatctatgg  tatttttct  tgtga  2735



<210> 7641
<211> 328
<212> PRT
<213> Homo sapiens
<308> P30968
<400> 7641

Met Ala Asn Ser Ala Ser Pro Glu Gln Asn Gln Asn His Cys Ser Ala 
  1               5                  10                  15
Ile Asn Asn Ser Ile Pro Leu Met Gln Gly Asn Leu Pro Thr Leu Thr 
             20                  25                  30
Leu Ser Gly Lys Ile Arg Val Thr Val Thr Phe Phe Leu Phe Leu Leu 
         35                  40                  45
Ser Ala Thr Phe Asn Ala Ser Phe Leu Leu Lys Leu Gln Lys Trp Thr 
     50                  55                  60
Gln Lys Lys Glu Lys Gly Lys Lys Leu Ser Arg Met Lys Leu Leu Leu 
 65                  70                  75                  80
Lys His Leu Thr Leu Ala Asn Leu Leu Glu Thr Leu Ile Val Met Pro 
                 85                  90                  95
Leu Asp Gly Met Trp Asn Ile Thr Val Gln Trp Tyr Ala Gly Glu Leu 
             100                105                110
Leu Cys Lys Val Leu Ser Tyr Leu Lys Leu Phe Ser Met Tyr Ala Pro 
         115                120                125
Ala Phe Met Met Val Val Ile Ser Leu Asp Arg Ser Leu Ala Ile Thr 
     130                135                140
Arg Pro Leu Ala Leu Lys Ser Asn Ser Lys Val Gly Gln Ser Met Val 
 145                150                155                160
Gly Leu Ala Trp Ile Leu Ser Ser Val Phe Ala Gly Pro Gln Leu Tyr 
                 165                170                175
Ile Phe Arg Met Ile His Leu Ala Asp Ser Ser Gly Gln Thr Lys Val 
             180                185                190
Phe Ser Gln Cys Val Thr His Cys Ser Phe Ser Gln Trp Trp His Gln 
         195                200                205
Ala Phe Tyr Asn Phe Phe Thr Phe Ser Cys Leu Phe Ile Ile Pro Leu 
     210                215                220
Phe Ile Met Leu Ile Cys Asn Ala Lys Ile Ile Phe Thr Leu Thr Arg 
 225                230                235                240
Val Leu His Gln Asp Pro His Glu Leu Gln Leu Asn Gln Ser Lys Asn 
                 245                250                255
Asn Ile Pro Arg Ala Arg Leu Lys Thr Leu Lys Met Thr Val Ala Phe 
             260                265                270
Ala Thr Ser Phe Thr Val Cys Trp Thr Pro Tyr Tyr Val Leu Gly Ile 
         275                280                285
Trp Tyr Trp Phe Asp Pro Glu Met Leu Asn Arg Leu Ser Asp Pro Val 
     290                295                300
Asn His Phe Phe Phe Leu Phe Ala Phe Leu Asn Pro Cys Phe Asp Pro 
 305                310                315                320
Leu Ile Tyr Gly Tyr Phe Ser Leu 
                 325



<210> 7642
<211> 2672
<212> DNA
<213> Rattus norvegicus
<308> S62096
<400> 7642

ccggactac  tctggaccc  ctcccctgt  cccaacgct  agccgaaac  atgcatggg  60
gcctgaagg  gaagacgtc  gaagagcag  cagaggcca  aaggctaga  cgagagcag  120
agctaaagc  ctaccagtc  gccactcaa  ctgtcttcc  gaagcgtca  gctggtgag  180
tggatgaat  agtgctaga  ctgacaagc  agattctgg  agccaaccc  gattttgcc  240
ccctctgga  ctgtcgaag  gaagtactc  agcacctgg  aaccgagaa  tcccctgag  300
agtcagctg  tcttgtgaa  gcagaactg  gcttcctag  gagctgtct  cgtgtgaac  360
ctaagtcct  tggcacttg  caccaccgc  gctggctgc  gagtcgcct  cctgagccc  420
actgggccc  ggagctgga  ctatgcgct  gcttcctcg  ggccgatga  cggaacttt  480
attgctggg  ctatcggcg  tttgtagcc  cacaggctg  tgttgcccc  gcagaggaa  540
tagccttca  tgacagcct  atcacccgt  acttctcca  ctattcctc  tggcattat  600
gctcctgcc  cttgccaca  ctgcacccc  agccagact  tggcccaca  ggtcggctc  660
ctgaaaatg  actgctgaa  gagctggag  tggtgcaga  tgccttctt  actgacccc  720
acgatcaga  tgcctggtt  tatcaccgc  ggctcctgg  tcgggcgga  ccccacgat  780
ttctatgct  tgtgcatgt  agccgggag  aggcctgtc  gtcggtctg  ttttctcgt  840
ccctgacag  gggctccag  atggggacc  tgctactca  ggttgatga  gcacctttg  900
gtgtggagt  gaggactcc  gatggcagg  accggccca  ccatgtctg  ctctgtgac  960
tgcctgctg  ctctctcaa  gaccagttg  cccagcaca  gtttcgtgt  atctggaca  1020
gaagtgata  ccagaagga  tgtgtgctt  taaaagacc  cccagaatg  tggtgccga  1080
actcagcca  tgatgaaca  ctattcagg  gtgagctgt  agtggaaaa  tccacagtg  1140
tgcagtctg  gcttgaatc  tgtaaggag  tgcaggaac  agagcctga  aataaatgg  1200
gcctgctga  catcatcct  ctgatgcga  cactggacc  cctcctcta  gagaaggaa  1260
cactgcagt  cttcagtac  ctcaaagct  tggacccaa  gagagcagc  tacttggat  1320
acctgcgca  caagttctt  ctggagaac  gtgttctca  gatggagta  gctgatgta  1380
gcgtgctgc  cctggctca  aaggatctc  cagtgctct  ccacctgga  caactgctc  1440
tggtcactc  tcttgacct  tcccataat  gactccgag  cttaccccc  gccctggct  1500
ctctgcgct  tcttgaggt  ctgcaggcc  gtgacaatg  cctggagaa  gtggatggt  1560
tggctaacc  tccccggct  caagagctg  tactatgta  taaccgcct  caacagtct  1620
cagcaatcc  gcctcttgt  tcctgcccc  ggctagtcc  cctcaacct  cagggcaac  1680
cgctgtgcc  agaagaggg  atccaggag  gtttggctg  gatgctacc  tctgtcagc  1740
gcatcctca  ctaggaggc  ctgcctcat  ctcaccttt  acttactgg  actgaataa  1800
gtgtggaga  gcccctcta  cacttgacc  ctgccatga  aacactacc  ccattacca  1860
cactgtttt  aagaaagga  gggaggggc  ctgtggtga  ggtctactg  cctgtgata  1920
tctctaccc  gagcctctg  gttcatgtc  ggtcaggac  acagctgga  ttgagttca  1980
catcagttt  ggggctgtc  tgggagcct  gcttgagac  gggatagaa  tcgggctcg  2040
gttatgatt  gggctgagc  tcagaacag  tgtctctag  tggaagaga  tgtgaacct  2100
tctctcgtg  gtctgccaa  ttcagactt  gtgtcctga  ccctgcttc  ttcacaacg  2160
aataggctc  ggacctcag  gtttgagaa  gaatgtgtc  gggcatctt  ccccacctg  2220
ttaagatga  aatattggt  cttgtggat  acattctat  gttgaaaag  ccttgggaa  2280
ccttggtcc  gtttgatcc  catacactc  gggatggga  gattagaac  tttgaactg  2340
tgaagagac  gttctgacc  gcccagggt  actgagctc  gcatgcgga  gccagatac  2400
aaccacgtt  cttcagtga  ttagccctt  tcctgtttc  gtattaatg  agaatgatt  2460
aacagaggc  cggcctcaa  tcgccaagg  atttagata  gagcctact  ctgagttgc  2520
tccacaccc  accactcgg  gttgtgact  tgaaagctg  agggaacaa  gcctccagg  2580
agtggctca  gggtttggg  actgagtca  acttggcat  gtgagggaa  atggtgact  2640
attaaaacg  gaagagtgt  aaaaaaaaa  aa  2672



<210> 7643
<211> 567
<212> PRT
<213> Rattus norvegicus
<308> AAB27018
<400> 7643

Met His Gly Arg Leu Lys Val Lys Thr Ser Glu Glu Gln Ala Glu Ala 
  1               5                  10                  15
Lys Arg Leu Glu Arg Glu Gln Lys Leu Lys Leu Tyr Gln Ser Ala Thr 
             20                  25                  30
Gln Ala Val Phe Gln Lys Arg Gln Ala Gly Glu Leu Asp Glu Ser Val 
         35                  40                  45
Leu Glu Leu Thr Ser Gln Ile Leu Gly Ala Asn Pro Asp Phe Ala Thr 
     50                  55                  60
Leu Trp Asn Cys Arg Arg Glu Val Leu Gln His Leu Glu Thr Glu Lys 
 65                  70                  75                  80
Ser Pro Glu Glu Ser Ala Ala Leu Val Lys Ala Glu Leu Gly Phe Leu 
                 85                  90                  95
Glu Ser Cys Leu Arg Val Asn Pro Lys Ser Tyr Gly Thr Trp His His 
             100                105                110
Arg Cys Trp Leu Leu Ser Arg Leu Pro Glu Pro Asn Trp Ala Arg Glu 
         115                120                125
Leu Glu Leu Cys Ala Arg Phe Leu Glu Ala Asp Glu Arg Asn Phe His 
     130                135                140
Cys Trp Asp Tyr Arg Arg Phe Val Ala Ala Gln Ala Ala Val Ala Pro 
 145                150                155                160
Ala Glu Glu Leu Ala Phe Thr Asp Ser Leu Ile Thr Arg Asn Phe Ser 
                 165                170                175
Asn Tyr Ser Ser Trp His Tyr Arg Ser Cys Leu Leu Pro Gln Leu His 
             180                185                190
Pro Gln Pro Asp Ser Gly Pro Gln Gly Arg Leu Pro Glu Asn Val Leu 
         195                200                205
Leu Lys Glu Leu Glu Leu Val Gln Asn Ala Phe Phe Thr Asp Pro Asn 
     210                215                220
Asp Gln Ser Ala Trp Phe Tyr His Arg Trp Leu Leu Gly Arg Ala Glu 
 225                230                235                240
Pro His Asp Val Leu Cys Cys Val His Val Ser Arg Glu Glu Ala Cys 
                 245                250                255
Leu Ser Val Cys Phe Ser Arg Pro Leu Thr Val Gly Ser Arg Met Gly 
             260                265                270
Thr Leu Leu Leu Met Val Asp Glu Ala Pro Leu Ser Val Glu Trp Arg 
         275                280                285
Thr Pro Asp Gly Arg Asn Arg Pro Ser His Val Trp Leu Cys Asp Leu 
     290                295                300
Pro Ala Ala Ser Leu Asn Asp Gln Leu Pro Gln His Thr Phe Arg Val 
 305                310                315                320
Ile Trp Thr Gly Ser Asp Ser Gln Lys Glu Cys Val Leu Leu Lys Asp 
                 325                330                335
Arg Pro Glu Cys Trp Cys Arg Asp Ser Ala Thr Asp Glu Gln Leu Phe 
             340                345                350
Arg Cys Glu Leu Ser Val Glu Lys Ser Thr Val Leu Gln Ser Glu Leu 
         355                360                365
Glu Ser Cys Lys Glu Leu Gln Glu Leu Glu Pro Glu Asn Lys Trp Cys 
     370                375                380
Leu Leu Thr Ile Ile Leu Leu Met Arg Ala Leu Asp Pro Leu Leu Tyr 
 385                390                395                400
Glu Lys Glu Thr Leu Gln Tyr Phe Ser Thr Leu Lys Ala Val Asp Pro 
                 405                410                415
Met Arg Ala Ala Tyr Leu Asp Asp Leu Arg Ser Lys Phe Leu Leu Glu 
             420                425                430
Asn Ser Val Leu Lys Met Glu Tyr Ala Asp Val Arg Val Leu His Leu 
         435                440                445
Ala His Lys Asp Leu Thr Val Leu Cys His Leu Glu Gln Leu Leu Leu 
     450                455                460
Val Thr His Leu Asp Leu Ser His Asn Arg Leu Arg Ala Leu Pro Pro 
 465                470                475                480
Ala Leu Ala Ala Leu Arg Cys Leu Glu Val Leu Gln Ala Ser Asp Asn 
                 485                490                495
Ala Leu Glu Asn Val Asp Gly Val Ala Asn Leu Pro Arg Leu Gln Glu 
             500                505                510
Leu Leu Leu Cys Asn Asn Arg Leu Gln Gln Ser Ala Ala Ile Gln Pro 
         515                520                525
Leu Val Ser Cys Pro Arg Leu Val Leu Leu Asn Leu Gln Gly Asn Ser 
     530                535                540
Leu Cys Gln Glu Glu Gly Ile Gln Glu Arg Leu Ala Glu Met Leu Pro 
 545                550                555                560
Ser Val Ser Ser Ile Leu Thr 
                 565



<210> 7644
<211> 2067
<212> DNA
<213> Homo sapiens
<308> NM_004581
<400> 7644

gaattccct  gcgctctgg  ccgggcgaa  cgggntata  gaagggcca  acggatgga  60
gtcctagtc  gggtgctca  ctcttgtgg  acgtgcaaa  cctgtccca  gacctctct  120
cactctggg  gtctctgcc  aggcacgct  gctgcttcc  gacacagct  tgggcggag  180
tagtagggg  gggctacgt  attgacact  ctctcctca  acttcaagg  ctaccactg  240
acccttccc  tgtcttgaa  cctgagccg  caccatgca  ggacgcctg  aggtgaaga  300
gtcagaaga  caggcggag  ccaaaaggc  agagcgaga  cagaagctg  agctatacc  360
gtcagccac  caggccgta  tccagaagc  ccaggctgg  gagctggat  agtccgtgc  420
ggaactgac  agccagatt  tgggagcca  ccctgattt  gccaccctc  ggaactgcc  480
acgagaggt  ctccagcag  tggagactc  gaagtctcc  gaagagttg  ctgctctgg  540
gaaggcaga  ctgggcttc  tggagagct  cctgcgggt  aaccccaag  cttatggta  600
ctggcacca  cgatgctgg  tgctaggcc  cctgcctga  cccaactgg  cccgagagc  660
ggagctctg  gcccgtttc  tggaggtgg  tgagcggaa  tttcactgc  gggactatc  720
gcggtttgt  gccacacag  cagccgtgc  ccctgcaga  gagctagcc  tcactgaca  780
cctcatcac  cgaaacttc  ccaactact  ttcctggca  taccgctcc  gtctcttgc  840
ccagttgca  ccccagccg  attctggac  acaggggcg  ctccctgag  atgtgctgc  900
caaagagct  gagctggtg  agaatgcct  cttcactga  cccaatgac  agagtgcct  960
gttttatca  cggtggctc  taggtcgag  tgaccccca  gatgcactg  gctgtctgc  1020
tgtgagccg  gacgaggcc  gtctgactg  ctccttctc  cggcccctc  tagtgggct  1080
caggatgga  atcttgctg  tcatggttg  tgattctcc  ctgattgtg  agtggagga  1140
cccagatgg  aggaaccgg  ccagccatg  ctggctctg  gacctgcct  ctgcctccc  1200
caacgacca  ttgccccaa  atacatttc  cgtcatttg  acagcaggc  atgtccaga  1260
agaatgcgt  cttttaaaa  gccgccagg  gggctggtg  cgggactcc  cgacagacg  1320
gcagctatt  aggtgtgag  tgtcagtgg  gaagtccac  gtgctgcag  ctgagctgg  1380
atcctgtaa  gagctgcag  agctggagc  tgagaataa  tggtgcctg  ttaccatca  1440
cctgctgat  cgggcactg  accccctgc  gtatgagaa  gagaccctg  agtacttcc  1500
gaccctcaa  gccgtggac  ccatgcggg  aacgtatct  gatgacctg  gcagcaagt  1560
cttgctgga  aatagcgtg  tcaagatgg  gtatgccga  gtgcgtgtg  tgcacctgg  1620
tcacaagga  ctgacagtg  tctgccatc  ggaacagct  ctcttggtc  cccatcttg  1680
cttgtcaca  aatcgcctc  gaaccctgc  acctgcact  gctgccctg  gctgccttg  1740
ggtgctgca  gccagtgat  atgcaatag  gtccctgga  ggcgtcacc  acctacccc  1800
gctgcagga  ctgctactg  gcaacaacc  cctccagca  cctgcagtg  tccagcctc  1860
tgcctcctg  cccaggctg  tcctcctca  cctgcaggg  aacccgctg  gccaagcgg  1920
gggcatctt  gagcaactg  ctgaactgc  gccttcagt  agcagcgtc  tcacctaag  1980
ggccctgcc  cctaccctt  ccctttaac  tattgggac  gaataaaga  tggagaggc  2040
cctctcagg  taccaaaaa  aaaaaaa  2067



<210> 7645
<211> 567
<212> PRT
<213> Homo sapiens
<308> Q92696
<400> 7645

Met His Gly Arg Leu Lys Val Lys Thr Ser Glu Glu Gln Ala Glu Ala 
  1               5                  10                  15
Lys Arg Leu Glu Arg Glu Gln Lys Leu Lys Leu Tyr Gln Ser Ala Thr 
             20                  25                  30
Gln Ala Val Phe Gln Lys Arg Gln Ala Gly Glu Leu Asp Glu Ser Val 
         35                  40                  45
Leu Glu Leu Thr Ser Gln Ile Leu Gly Ala Asn Pro Asp Phe Ala Thr 
     50                  55                  60
Leu Trp Asn Cys Arg Arg Glu Val Leu Gln Gln Leu Glu Thr Gln Lys 
 65                  70                  75                  80
Ser Pro Glu Glu Leu Ala Ala Leu Val Lys Ala Glu Leu Gly Phe Leu 
                 85                  90                  95
Glu Ser Cys Leu Arg Val Asn Pro Lys Ser Tyr Gly Thr Trp His His 
             100                105                110
Arg Cys Trp Leu Leu Gly Arg Leu Pro Glu Pro Asn Trp Thr Arg Glu 
         115                120                125
Leu Glu Leu Cys Ala Arg Phe Leu Glu Val Asp Glu Arg Asn Phe His 
     130                135                140
Cys Trp Asp Tyr Arg Arg Phe Val Ala Thr Gln Ala Ala Val Pro Pro 
 145                150                155                160
Ala Glu Glu Leu Ala Phe Thr Asp Ser Leu Ile Thr Arg Asn Phe Ser 
                 165                170                175
Asn Tyr Ser Ser Trp His Tyr Arg Ser Cys Leu Leu Pro Gln Leu His 
             180                185                190
Pro Gln Pro Asp Ser Gly Pro Gln Gly Arg Leu Pro Glu Asp Val Leu 
         195                200                205
Leu Lys Glu Leu Glu Leu Val Gln Asn Ala Phe Phe Thr Asp Pro Asn 
     210                215                220
Asp Gln Ser Ala Trp Phe Tyr His Arg Trp Leu Leu Gly Arg Ala Asp 
 225                230                235                240
Pro Gln Asp Ala Leu Arg Cys Leu His Val Ser Arg Asp Glu Ala Cys 
                 245                250                255
Leu Thr Val Ser Phe Ser Arg Pro Leu Leu Val Gly Ser Arg Met Glu 
             260                265                270
Ile Leu Leu Leu Met Val Asp Asp Ser Pro Leu Ile Val Glu Trp Arg 
         275                280                285
Thr Pro Asp Gly Arg Asn Arg Pro Ser His Val Trp Leu Cys Asp Leu 
     290                295                300
Pro Ala Ala Ser Leu Asn Asp Gln Leu Pro Gln His Thr Phe Arg Val 
 305                310                315                320
Ile Trp Thr Ala Gly Asp Val Gln Lys Glu Cys Val Leu Leu Lys Gly 
                 325                330                335
Arg Gln Glu Gly Trp Cys Arg Asp Ser Thr Thr Asp Glu Gln Leu Phe 
             340                345                350
Arg Cys Glu Leu Ser Val Glu Lys Ser Thr Val Leu Gln Ser Glu Leu 
         355                360                365
Glu Ser Cys Lys Glu Leu Gln Glu Leu Glu Pro Glu Asn Lys Trp Cys 
     370                375                380
Leu Leu Thr Ile Ile Leu Leu Met Arg Ala Leu Asp Pro Leu Leu Tyr 
 385                390                395                400
Glu Lys Glu Thr Leu Gln Tyr Phe Gln Thr Leu Lys Ala Val Asp Pro 
                 405                410                415
Met Arg Ala Thr Tyr Leu Asp Asp Leu Arg Ser Lys Phe Leu Leu Glu 
             420                425                430
Asn Ser Val Leu Lys Met Glu Tyr Ala Glu Val Arg Val Leu His Leu 
         435                440                445
Ala His Lys Asp Leu Thr Val Leu Cys His Leu Glu Gln Leu Leu Leu 
     450                455                460
Val Thr His Leu Asp Leu Ser His Asn Arg Leu Arg Thr Leu Pro Pro 
 465                470                475                480
Ala Leu Ala Ala Leu Arg Cys Leu Glu Val Leu Gln Ala Ser Asp Asn 
                 485                490                495
Ala Ile Glu Ser Leu Asp Gly Val Thr Asn Leu Pro Arg Leu Gln Glu 
             500                505                510
Leu Leu Leu Cys Asn Asn Arg Leu Gln Gln Pro Ala Val Leu Gln Pro 
         515                520                525
Leu Ala Ser Cys Pro Arg Leu Val Leu Leu Asn Leu Gln Gly Asn Pro 
     530                535                540
Leu Cys Gln Ala Val Gly Ile Leu Glu Gln Leu Ala Glu Leu Leu Pro 
 545                550                555                560
Ser Val Ser Ser Val Leu Thr 
                 565



<210> 7646
<211> 1344
<212> DNA
<213> Rattus norvegicus
<308> S62097
<400> 7646

cggcacgag  acatgggca  acagcagaa  gacgtcacc  tcaagtcag  tgcgcctga  60
accctgctg  tcgagaagc  tgctgatta  atcgcctcg  acggctcaa  gaaagatga  120
tatgaatac  gcatgtccg  atacttgag  atgagcggc  tctactggg  cctgacagt  180
atggacctc  tggggcagc  tcatcggat  aataaagag  agatactgg  gtttatcaa  240
tcgtgccag  atgagtgtg  gggagtcag  gccagcatc  ggcacgacc  ccaccttct  300
tacacgctc  gtgctgtcc  gattctcac  ctgtatgat  gcatccatg  aatcaacgt  360
gacaaagtg  tagcctatg  tcagagtct  cagaaagaa  atggttcct  tgctggaga  420
atctgggga  aaatcgata  aagattctc  ttttgtgca  tggcaactt  ggctctctt  480
ggcaaactt  atgctatta  tgtggaaaa  gccattgaa  ttgttttgt  ctgtatgaa  540
tttgatggt  gatttgggt  cagaccagg  tctgaatct  acgccggac  gatctattg  600
tgcacagga  tcctggcca  aactagtca  ttgcatcaa  tgaactccg  cctacttgg  660
tggtggctt  gtgaacgac  gttgccctc  ggcggactc  atggaagac  cgagaagtt  720
ccagatgtg  gctattcct  gtgggtgtt  gcctcctta  agataatcg  gaggcttca  780
tggattgac  gagaaaagc  tcgaagctt  atcttggca  gtcaagatg  agagacagg  840
gggtttgca  acaggccag  agacatggt  gatcccttt  acaccttgt  tggcattgc  900
ggattgtca  ttctggggg  agagcagat  aagcctgtc  gccctgtct  ttgcatgcc  960
gaagaagtg  tacagaggg  gaatgtcca  cctgaacta  tgagctagt  cgaggggaa  1020
agccttcgg  gtgcagtat  agttactgt  gttatcaaa  ccagaagtg  cttaatatt  1080
tgtatatca  atgtcaatg  taaattata  aagtattgt  aaataaatg  catatttag  1140
tctttagtg  tctgagtac  gtttctgtc  atactgttt  ttaatgtct  acagcagca  1200
acttaaaaa  ctagtattt  actgccatc  ccctgtgtc  ttttgacct  taacaatga  1260
gggaaatga  ttctgttaa  aaagatgat  aaagtgagt  aaactcatg  tttaaataa  1320
agatgcata  aatcgagct  gtcc  1344



<210> 7647
<211> 331
<212> PRT
<213> Rattus norvegicus
<308> AAB27019
<400> 7647

Met Gly Thr Gln Gln Lys Asp Val Thr Ile Lys Ser Asp Ala Pro Asp 
  1               5                  10                  15
Thr Leu Leu Leu Glu Lys His Ala Asp Tyr Ile Ala Ser Tyr Gly Ser 
             20                  25                  30
Lys Lys Asp Asp Tyr Glu Tyr Cys Met Ser Glu Tyr Leu Arg Met Ser 
         35                  40                  45
Gly Val Tyr Trp Gly Leu Thr Val Met Asp Leu Met Gly Gln Leu His 
     50                  55                  60
Arg Met Asn Lys Glu Glu Ile Leu Val Phe Ile Lys Ser Cys Gln His 
 65                  70                  75                  80
Glu Cys Gly Gly Val Ser Ala Ser Ile Gly His Asp Pro His Leu Leu 
                 85                  90                  95
Tyr Thr Leu Ser Ala Val Gln Ile Leu Thr Leu Tyr Asp Ser Ile His 
             100                105                110
Val Ile Asn Val Asp Lys Val Val Ala Tyr Val Gln Ser Leu Gln Lys 
         115                120                125
Glu Asp Gly Ser Phe Ala Gly Asp Ile Trp Gly Glu Ile Asp Thr Arg 
     130                135                140
Phe Ser Phe Cys Ala Val Ala Thr Leu Ala Leu Leu Gly Lys Leu Asp 
 145                150                155                160
Ala Ile Asn Val Glu Lys Ala Ile Glu Phe Val Leu Ser Cys Met Asn 
                 165                170                175
Phe Asp Gly Gly Phe Gly Cys Arg Pro Gly Ser Glu Ser His Ala Gly 
             180                185                190
Gln Ile Tyr Cys Cys Thr Gly Phe Leu Ala Ile Thr Ser Gln Leu His 
         195                200                205
Gln Val Asn Ser Asp Leu Leu Gly Trp Trp Leu Cys Glu Arg Gln Leu 
     210                215                220
Pro Ser Gly Gly Leu Asn Gly Arg Pro Glu Lys Leu Pro Asp Val Cys 
 225                230                235                240
Tyr Ser Trp Trp Val Leu Ala Ser Leu Lys Ile Ile Gly Arg Leu His 
                 245                250                255
Trp Ile Asp Arg Glu Lys Leu Arg Ser Phe Ile Leu Ala Cys Gln Asp 
             260                265                270
Glu Glu Thr Gly Gly Phe Ala Asp Arg Pro Gly Asp Met Val Asp Pro 
         275                280                285
Phe His Thr Leu Phe Gly Ile Ala Gly Leu Ser Leu Leu Gly Glu Glu 
     290                295                300
Gln Ile Lys Pro Val Ser Pro Val Phe Cys Met Pro Glu Glu Val Leu 
 305                310                315                320
Gln Arg Val Asn Val Gln Pro Glu Leu Val Ser 
                 325                330



<210> 7648
<211> 1179
<212> DNA
<213> Homo sapiens
<308> X98001
<400> 7648

gaattcggc  cgaggcggt  agacatggg  actccacag  aggatgtta  tatcaagtc  60
gatgcaccg  acactttgt  attggagaa  catgcagat  atatcgcat  ctatggctc  120
aagaaagat  attatgaat  ctgtatgtc  gagtatttg  gaatgagtg  catctattg  180
ggtctgaca  taatggatc  catgggaca  cttcatcgc  tgaatagag  agagattct  240
gcatttatt  agtcttgcc  acatgaatg  ggtggaata  gtgctagta  cggacatga  300
cctcatctt  tatacactc  tagtgctgt  cagattctt  cgctgtatg  cagtattaa  360
gttattgac  taaataaag  tgtggaata  gttaaaggt  tacagaaag  agatggttc  420
tttgctgga  atatttggg  agaaattga  acaagattc  ctttttgtg  ggtggcaac  480
ttggctttg  tggggaagc  tgatgctat  aatgtggaa  aggcaatcg  atttgtttt  540
tcctgtatg  actttgacg  tggatttgg  tgcagacca  gttctgaat  ccatgctgg  600
cagatctat  gttgcacag  atttctggc  attacaagt  agttgcatc  agtaaattc  660
gatttactt  gctggtggc  ttgtgaacg  caattaccc  caggcgggc  caatggaag  720
ccggagaag  taccagatg  atgctactc  tggtgggtc  tggcttccc  aaagataat  780
ggaagactt  attggattg  tagagagaa  ctgcgtaat  tcattttag  atgtcaaga  840
gaagaaacg  ggggatttg  agacaggcc  ggagatatg  tggatcctt  tcatacctt  900
tttggaatt  ctggattgt  acttttggg  gaagaacag  ttaaacctg  taatcctgt  960
ttttgcatg  ctgaagaag  gcttcagag  gtgaatgtt  agcctgagc  agtgagcta  1020
attcattga  ttgaaagtt  catagtata  ttttgccat  ttaacattt  tgtatttga  1080
gtgcttatc  aatctaaaa  tgactactg  taatatttt  tatattgtg  taaattaat  1140
ttaataaat  atataatta  gcatattgt  aaataaaaa  1179



<210> 7649
<211> 331
<212> PRT
<213> Homo sapiens
<308> P53611
<400> 7649

Met Gly Thr Pro Gln Lys Asp Val Ile Ile Lys Ser Asp Ala Pro Asp 
  1               5                  10                  15
Thr Leu Leu Leu Glu Lys His Ala Asp Tyr Ile Ala Ser Tyr Gly Ser 
             20                  25                  30
Lys Lys Asp Asp Tyr Glu Tyr Cys Met Ser Glu Tyr Leu Arg Met Ser 
         35                  40                  45
Gly Ile Tyr Trp Gly Leu Thr Val Met Asp Leu Met Gly Gln Leu His 
     50                  55                  60
Arg Met Asn Arg Glu Glu Ile Leu Ala Phe Ile Lys Ser Cys Gln His 
 65                  70                  75                  80
Glu Cys Gly Gly Ile Ser Ala Ser Ile Gly His Asp Pro His Leu Leu 
                 85                  90                  95
Tyr Thr Leu Ser Ala Val Gln Ile Leu Thr Leu Tyr Asp Ser Ile Asn 
             100                105                110
Val Ile Asp Val Asn Lys Val Val Glu Tyr Val Lys Gly Leu Gln Lys 
         115                120                125
Glu Asp Gly Ser Phe Ala Gly Asp Ile Trp Gly Glu Ile Asp Thr Arg 
     130                135                140
Phe Ser Phe Cys Ala Val Ala Thr Leu Ala Leu Leu Gly Lys Leu Asp 
 145                150                155                160
Ala Ile Asn Val Glu Lys Ala Ile Glu Phe Val Leu Ser Cys Met Asn 
                 165                170                175
Phe Asp Gly Gly Phe Gly Cys Arg Pro Gly Ser Glu Ser His Ala Gly 
             180                185                190
Gln Ile Tyr Cys Cys Thr Gly Phe Leu Ala Ile Thr Ser Gln Leu His 
         195                200                205
Gln Val Asn Ser Asp Leu Leu Gly Trp Trp Leu Cys Glu Arg Gln Leu 
     210                215                220
Pro Ser Gly Gly Leu Asn Gly Arg Pro Glu Lys Leu Pro Asp Val Cys 
 225                230                235                240
Tyr Ser Trp Trp Val Leu Ala Ser Leu Lys Ile Ile Gly Arg Leu His 
                 245                250                255
Trp Ile Asp Arg Glu Lys Leu Arg Asn Phe Ile Leu Ala Cys Gln Asp 
             260                265                270
Glu Glu Thr Gly Gly Phe Ala Asp Arg Pro Gly Asp Met Val Asp Pro 
         275                280                285
Phe His Thr Leu Phe Gly Ile Ala Gly Leu Ser Leu Leu Gly Glu Glu 
     290                295                300
Gln Ile Lys Pro Val Asn Pro Val Phe Cys Met Pro Glu Glu Val Leu 
 305                310                315                320
Gln Arg Val Asn Val Gln Pro Glu Leu Val Ser 
                 325                330



<210> 7650
<211> 1343
<212> DNA
<213> Rattus norvegicus
<308> S63521
<400> 7650

gaattccaa  gattcagca  ttggtgaaa  agttcttca  tggcaagga  ccgtcccgt  60
gcatcaacc  agatgaggc  gtagcatat  gtgccgctg  ccaggctgg  gtcctctct  120
gtgatcaag  tacaggtga  ctggttctg  ttgatgtgt  tcctcttac  cttggtatt  180
aaactgtgg  aggtgtcat  acaaaactg  ttccgagga  cactgtggt  cccaccaag  240
agtctcaga  cttctccac  gcttctgat  atcagccca  cgtaacaat  aaggtctac  300
aaggtgaac  acccctgac  aaagacaat  accttctgg  tacatttga  ctgactgga  360
tccctcctg  tccccgtgg  gtaccccag  ttgaagtca  ctttgagat  gatgtgaat  420
gtattcttc  agtgacagc  gaagacaaa  ggacaggaa  caaaaacaa  atcaccatc  480
ccaatgacc  aaaccgcct  acccctgaa  aaattgaaa  gatggtcaa  gacgccgag  540
agtttgctg  ggaagacaa  aagctcaaa  agcgcattg  cacgaggaa  gaattggaa  600
gctatgctt  ctctcttaa  aaccagatc  gagataaag  gaagctggg  ggtaagctg  660
ctcctgaag  taaagagac  atggagaaa  ctgtagagg  aaagatcga  tggctggaa  720
gccaccagg  tgcagacat  gaagacttt  aagctaaaa  gaaggaact  gaagaaatt  780
ttcagccaa  tatcagcaa  ctctatgga  gtggaggcc  tcccccaac  ggtgaagag  840
atacatcag  aaaagatga  ttgtaggtg  actgatctg  tagagctgt  atattgtaa  900
tactggact  aggaacttt  gttgggaga  aattgagag  acttaagtc  cgaatgtaa  960
tggaatctt  acctcagag  ggagttgaa  atgctatag  ccaagtggc  gtttactgc  1020
tttcattag  agttgctca  gtgtcttgg  gtcagggag  ggaggaatt  gctatttta  1080
aattgggga  aagctgggt  agggtgtgt  ttcaccttg  atatgttct  tttaacggt  1140
gggtcatgc  catctggtg  aggaacttt  ttctaccat  agtgacacc  ataaatgtt  1200
gttatttac  ctggtctag  ttttgtgaa  agcttgtaa  tatatccat  ttttatttt  1260
gataactaa  atttaagac  ggaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1320
aaaaaaaaa  aaaaaaaaa  aaa  1343



<210> 7651
<211> 1343
<212> DNA
<213> Rattus norvegicus
<308> S63521
<400> 7651

gaattccaa  gattcagca  ttggtgaaa  agttcttca  tggcaagga  ccgtcccgt  60
gcatcaacc  agatgaggc  gtagcatat  gtgccgctg  ccaggctgg  gtcctctct  120
gtgatcaag  tacaggtga  ctggttctg  ttgatgtgt  tcctcttac  cttggtatt  180
aaactgtgg  aggtgtcat  acaaaactg  ttccgagga  cactgtggt  cccaccaag  240
agtctcaga  cttctccac  gcttctgat  atcagccca  cgtaacaat  aaggtctac  300
aaggtgaac  acccctgac  aaagacaat  accttctgg  tacatttga  ctgactgga  360
tccctcctg  tccccgtgg  gtaccccag  ttgaagtca  ctttgagat  gatgtgaat  420
gtattcttc  agtgacagc  gaagacaaa  ggacaggaa  caaaaacaa  atcaccatc  480
ccaatgacc  aaaccgcct  acccctgaa  aaattgaaa  gatggtcaa  gacgccgag  540
agtttgctg  ggaagacaa  aagctcaaa  agcgcattg  cacgaggaa  gaattggaa  600
gctatgctt  ctctcttaa  aaccagatc  gagataaag  gaagctggg  ggtaagctg  660
ctcctgaag  taaagagac  atggagaaa  ctgtagagg  aaagatcga  tggctggaa  720
gccaccagg  tgcagacat  gaagacttt  aagctaaaa  gaaggaact  gaagaaatt  780
ttcagccaa  tatcagcaa  ctctatgga  gtggaggcc  tcccccaac  ggtgaagag  840
atacatcag  aaaagatga  ttgtaggtg  actgatctg  tagagctgt  atattgtaa  900
tactggact  aggaacttt  gttgggaga  aattgagag  acttaagtc  cgaatgtaa  960
tggaatctt  acctcagag  ggagttgaa  atgctatag  ccaagtggc  gtttactgc  1020
tttcattag  agttgctca  gtgtcttgg  gtcagggag  ggaggaatt  gctatttta  1080
aattgggga  aagctgggt  agggtgtgt  ttcaccttg  atatgttct  tttaacggt  1140
gggtcatgc  catctggtg  aggaacttt  ttctaccat  agtgacacc  ataaatgtt  1200
gttatttac  ctggtctag  ttttgtgaa  agcttgtaa  tatatccat  ttttatttt  1260
gataactaa  atttaagac  ggaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1320
aaaaaaaaa  aaaaaaaaa  aaa  1343



<210> 7652
<211> 2018
<212> DNA
<213> Rattus norvegicus
<308> S65355
<400> 7652

ccccgagcg  actgctgag  atccgctgt  tggcattct  tcagccttt  gtccgagcc  60
gagctgcat  cagaggaga  aggcccgct  aggagcagc  ggactcctg  tgcgagccg  120
aagccccct  aggcagttg  ggacctggg  aggaggctc  ctgctggtg  cgcttctcc  180
ggtgcttcc  atccgtgcg  gactgaaaa  ggcggagcg  ctacgggac  ctcacagga  240
caagctgca  catgcaatc  tccgcaagc  ggtgcggac  cgccttggt  gcgctgctg  300
tggcctgtg  cttgttggg  gtatgggga  agaaaagag  attcccacc  gcccaggcc  360
caccatctc  tctcgggac  aaagaagtt  tgacgccac  cactaagac  tcctggact  420
gaggttcca  ctccagtct  atgcgttcc  ccgcacctg  ggaggtgac  aaaggaggg  480
gggtggctg  agtcccgcc  agatccttc  ctcctccgt  ccaacgaaa  attgagatc  540
acaagactt  taaatacat  aacacgatt  tatcatgcc  cgtgttcgt  ctaggcatc  600
tcgggaact  cacactgct  agaatcatc  acaagaaca  gtgcatgag  aatggtccc  660
atatcttga  cgccagcct  gctctggga  atctgctac  catcatcat  gacattccc  720
ttaatgcct  caagctgct  gcaggggac  ggccatttg  agctgagat  tgcaagctg  780
tgcccttca  acagaaggc  tctgtgggg  tcacagtgt  gagtctatg  gctctaagt  840
ttgacagat  tcgagctgt  gcttcttgg  gtcgaatta  aggaattgg  gttccaaaa  900
ggacagcag  agaaattgt  ttaatttgg  tggtctctg  ggttctggc  gtccctgaa  960
ccataggtt  tgatgtgat  acgtcggac  acaaaggaa  gcccctaag  gtctgcatg  1020
ttaatccct  tcagaaaac  gccttcatg  agttttaca  gacagccaa  gactggtgg  1080
tgttcagtt  ctacttctg  ttgccgcta  ccatcactg  gatctttta  accctaatg  1140
cctgtgaga  gctcagaaa  aaaagtggt  tgcagattg  cttgaatga  cacttaaag  1200
agagacgag  agtggccaa  acagtattc  gcctggtcc  cgtgtttgc  ctctgttgg  1260
ttccccttc  cctcagcag  attctgaag  tcacccttt  tgaccagag  aatcctcag  1320
ggtgtgaac  tctgagttt  ttgctggtt  tggactaca  tggtatcaa  atggcttct  1380
tgaattcct  cattaatcc  atcgctctg  atttggtga  caagagatt  aaaaactgc  1440
ttaagtcgt  tttgtgctg  tggtgccaa  cgtttgagg  aaaacagtc  ttagaggag  1500
agcaatcct  cttgaagtt  aaagctaac  atcacggat  cgacaactt  cgctccagc  1560
ataaataca  ctcatcttg  aggaaggaa  actcactga  tctcattgt  ctcatcgtg  1620
acagatagc  ttaaaacaa  atgaaacct  tgccaaacc  aaacggaaa  ccgtgcttg  1680
ggaaaggtg  gcacgcatg  gagagggat  gttttttaa  cgttctaac  ttccacacc  1740
gatatttca  gggctgttt  caacctaag  aagccatgg  aatgaatga  gcctcggga  1800
agcacttag  ttcttagtc  gcacttcag  acggctctt  aaagccctc  ctgcactca  1860
agcccactt  catttaaaa  caagaactc  aactctatt  aggggttta  tatccagtc  1920
tatgaatct  gatacagga  tgcatgaca  tgcaaaaca  ttcttaaag  aaagtttca  1980
ttgctcgat  tgagacaaa  aacaaaaca  aaaaaaaa  2018



<210> 7653
<211> 442
<212> PRT
<213> Rattus norvegicus
<308> AAB28172
<400> 7653

Met Gln Ser Ser Ala Ser Arg Cys Gly Arg Ala Leu Val Ala Leu Leu 
  1               5                  10                  15
Leu Ala Cys Gly Leu Leu Gly Val Trp Gly Glu Lys Arg Gly Phe Pro 
             20                  25                  30
Pro Ala Gln Ala Thr Pro Ser Leu Leu Gly Thr Lys Glu Val Met Thr 
         35                  40                  45
Pro Pro Thr Lys Thr Ser Trp Thr Arg Gly Ser Asn Ser Ser Leu Met 
     50                  55                  60
Arg Ser Ser Ala Pro Ala Glu Val Thr Lys Gly Gly Arg Val Ala Gly 
 65                  70                  75                  80
Val Pro Pro Arg Ser Phe Pro Pro Pro Cys Gln Arg Lys Ile Glu Ile 
                 85                  90                  95
Asn Lys Thr Phe Lys Tyr Ile Asn Thr Ile Val Ser Cys Leu Val Phe 
             100                105                110
Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
         115                120                125
Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
     130                135                140
Leu Gly Asp Leu Leu His Ile Ile Ile Asp Ile Pro Ile Asn Ala Tyr 
 145                150                155                160
Lys Leu Leu Ala Gly Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                 165                170                175
Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
             180                185                190
Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
         195                200                205
Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
     210                215                220
Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
 225                230                235                240
Asp Val Ile Thr Ser Asp Tyr Lys Gly Lys Pro Leu Arg Val Cys Met 
                 245                250                255
Leu Asn Pro Phe Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
             260                265                270
Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
         275                280                285
Thr Ala Ile Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
     290                295                300
Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
 305                310                315                320
Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                 325                330                335
Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asp Gln 
             340                345                350
Ser Asn Pro Gln Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
         355                360                365
Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
     370                375                380
Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
 385                390                395                400
Leu Cys Cys Trp Cys Gln Thr Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                 405                410                415
Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
             420                425                430
Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
         435                440



<210> 7654
<211> 4286
<212> DNA
<213> Homo sapiens
<308> NM_000115
<400> 7654

gagacattc  ggtggggga  tctggccag  ccgagcaac  tggatcctg  gagcactcc  60
aggtaggca  ttgccccgg  gggacgcct  gccagagca  tgtgtggca  gcccccgtg  120
aggatcaac  cagtggctg  acactggga  ggaactggt  cttggagtc  ggacatctg  180
aacttggct  tgaaactgc  cagcggcca  cggacgcct  ctggagcag  tagcagcat  240
cagccgcct  caagtctgt  cggacgcgc  ctggttgcg  tggttcttg  ctgcggcct  300
tcgcggatc  ggggagagg  gagaggctt  ccgcctgac  gggccactc  gcttttgca  360
accgcagag  taatgacgc  acccactaa  accttatgg  ccaagggtt  caacgccag  420
ctggcgcgg  cgttggcac  tgcggaggt  cctaaagga  acaggacgg  aggatctcc  480
ccacgcacc  tctcccctc  cccgtgcca  ggacccatc  agatcaagg  gactttcaa  540
tacatcaac  cggttgtgt  ctgccttgt  ttcgtgctg  ggatcatcg  gaactccac  600
cttctgaga  ttatctaca  gaacaagtg  atgcgaaac  gtcccaata  cttgatcgc  660
agcttggct  tgggagacc  gctgcacat  gtcattgac  tccctatca  tgtctacaa  720
ctgctggca  aggactggc  atttggagc  gagatgtgt  agctggtgc  tttcataca  780
aaagcctcc  tgggaatca  tgtgctgag  ctatgtgct  tgagtattg  cagatatcg  840
gctgttgct  cttggagta  aattaaagg  attggggtt  caaaatgga  agcagtaga  900
attgttttg  tttgggtgg  ctctgtggt  ctggctgtc  ctgaagcca  aggttttga  960
ataattacg  tggactaca  aggaagtta  ctgcgaatc  gcttgcttc  tcccgttca  1020
aagacagct  tcatgcagt  ttacaagac  gcaaaagat  ggtggctgt  cagtttcta  1080
ttctgcttg  cattggcca  cactgcatt  ttttataca  taatgacct  tgaaatgtt  1140
agaaagaaa  gtggcatgc  gattgcttt  aatgatcac  taaagcaga  acgggaagt  1200
gccaaaacc  tcttttgcc  ggtccttgt  tttgccctc  gctggcttc  ccttcacct  1260
agcaggatt  tgaagctca  tctttataa  cagaatgat  ccaatagat  tgaactttt  1320
agctttctg  tggtattgg  ctatattgg  atcaacatg  cttcactga  ttcctgcat  1380
aacccaatt  ctctgtatt  ggtgagcaa  agattcaaa  actgcttta  gtcatgctt  1440
tgctgctgg  gccagtcat  tgaagaaaa  cagtccttg  aggaaaagc  gtcgtgctt  1500
aagttcaaa  ctaatgatc  cggatatga  aacttccgt  ccagtaata  atacagctc  1560
tcttgaaag  agaactatt  actgtattt  attttcttt  tattggacc  aagtcatta  1620
aacaaaatg  aacatttgc  aaaacaaaa  aaaaaacta  gtatttgca  agcacacta  1680
taaaatatt  agtgtaatt  ttttaacac  cacagctac  tatgacatt  tatgagctg  1740
ttacggcat  gaaagaaaa  cagtgggaa  taagaaagc  tcgtcgtga  agcacttaa  1800
tttttacag  tagcacttc  acatagctc  taacaactt  caggatatt  acacaacac  1860
taggcttaa  aatgagctc  ctcagaatt  ctattcttt  taaaaagag  tttattttt  1920
aatcaatgg  actctgata  aaaggaaga  taagtcact  taaaacaga  cttttaaat  1980
aagcttaaa  tactcaatt  aaaatttta  aatccttta  aacaacttt  caattaata  2040
tatcacact  ttatcagat  gtaattaga  gcaaatgag  gagcagttt  gttgttgca  2100
ttttcggac  ctggaaaca  ttaaatgat  aggagggag  aacagaaag  gcaaggctg  2160
ttttgaaaa  cattacact  tcactagaa  cccaaacct  agcattctg  aatatgtaa  2220
caacatgtc  caaacaagc  gcatgtaac  gactggcac  tgtgccagc  gaatttaaa  2280
tataatact  ttaaaaaga  aattattac  tcctttaca  tcagttaag  tcaaacctc  2340
caaagagaa  tagaatgtt  gaaaggcta  cccaaaaga  ttttttgaa  ctgtcattc  2400
cataccctg  gaagacaat  ctatctaca  ttttttcag  attattaaa  tcttctttt  2460
tcactatcg  agcttaaac  ctgtttggt  ttgtcatct  taaatactt  cctacatac  2520
ctgcatgta  atgattaaa  gagggcagg  cctgtgctc  tagctttac  atggagaga  2580
gccagtgac  tcataataa  gactgtgaa  tgcctggtg  agtgtccac  tgacaaagg  2640
gcaggtagc  ccctctctc  cccatgctg  ggttaaaat  gtttctagc  tatgtataa  2700
gctatagtt  aaatactat  tttcaaaat  atacagatt  gtacattta  cagctacct  2760
taaagctta  tactaattt  tgtattatt  ttgtaaata  ccaatagaa  agtttgctt  2820
acatggtgc  tttctttca  ctagaggca  aactgcttt  tgagaccgt  agaacctct  2880
agctttgtg  gttcctgcc  aatttttat  tcttctaag  aaagtgcct  aggatagct  2940
gggatgaga  gtgtgtgaa  gtatgtaca  gagaaaacg  aagagagag  aaatgaggt  3000
gggttggag  aaacccatg  ggacagatt  ccattctta  cctaacgtt  gtcattgcc  3060
cgtcacatc  atgcaaaag  tcctgattt  gttccagca  aacacagtg  aatgttctc  3120
gagtgactt  cgaaataaa  tgggcccaa  agctttaac  cggtcttaa  atatgccca  3180
atttttact  tgtttttct  ttaataggc  gggccacat  ttggaaata  gctagtaat  3240
ttgttttct  tcaatattg  atgtgatgg  acagtaaac  aaaacccaa  aatgtggcc  3300
gaaagaaag  gcaataata  ttaattcac  caccatatg  attctattt  taaatcacc  3360
acaaacttg  tctttaatt  catcccaat  actttttca  aggcctgtt  tcatagaag  3420
cattttaga  tctcaattt  aaattaatt  tgaatcact  atattttca  agtttatta  3480
tatatttaa  ttctattta  attttagat  atttttatt  ccatgtact  aatttttac  3540
tcctgatac  ctttccttc  ccatgtcag  atcatgttc  ctaattatc  tgccaaatt  3600
tgaaactac  cacaaaaag  atacttgca  tatttataa  aaaattgca  tcagtggct  3660
tttaaaaaa  atgtttgat  caaaacttt  acatactga  aagtaagaa  caattataa  3720
ttctttaca  actcaaaac  aagatagaa  aaggtgcta  cgttcaact  caaaacatg  3780
ttcctagta  taaggactt  aatatagca  cagacaaaa  tattgttaa  atggatgtt  3840
cagctcaaa  gatttataa  agattttaa  ctattttct  ccttattat  cactgctaa  3900
gtggatgta  gttcaaaca  cttttagta  tgatagctt  catatggcc  aaggaatac  3960
gtttatagc  aaacatggg  atgctgtag  taactttat  aaagtgtaa  ataacaatg  4020
aaaaaatta  atatctggg  ggatttttt  gttgcctaa  gtggctata  ttactgatt  4080
tttattatg  aagcaaaac  aataaaaat  taagttttt  taacaacta  cttattttt  4140
actgtacag  cactaattc  ttaaatact  attgattgt  taaaagaaa  ataaatgtg  4200
caagtggac  ttatttatg  taaatatac  attatcaag  aagtatgaa  ttattcaat  4260
aaaatgcca  atttctggt  tctggg  4286



<210> 7655
<211> 442
<212> PRT
<213> Homo sapiens
<308> P24530
<400> 7655

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
  1               5                  10                  15
Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
             20                  25                  30
Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
         35                  40                  45
Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
     50                  55                  60
Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
 65                  70                  75                  80
Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                 85                  90                  95
Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
             100                105                110
Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
         115                120                125
Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
     130                135                140
Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
 145                150                155                160
Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                 165                170                175
Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
             180                185                190
Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
         195                200                205
Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
     210                215                220
Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
 225                230                235                240
Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                 245                250                255
Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
             260                265                270
Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
         275                280                285
Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
     290                295                300
Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
 305                310                315                320
Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                 325                330                335
Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
             340                345                350
Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
         355                360                365
Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
     370                375                380
Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
 385                390                395                400
Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                 405                410                415
Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
             420                425                430
Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
         435                440



<210> 7656
<211> 2018
<212> DNA
<213> Rattus norvegicus
<308> S65355
<400> 7656

ccccgagcg  actgctgag  atccgctgt  tggcattct  tcagccttt  gtccgagcc  60
gagctgcat  cagaggaga  aggcccgct  aggagcagc  ggactcctg  tgcgagccg  120
aagccccct  aggcagttg  ggacctggg  aggaggctc  ctgctggtg  cgcttctcc  180
ggtgcttcc  atccgtgcg  gactgaaaa  ggcggagcg  ctacgggac  ctcacagga  240
caagctgca  catgcaatc  tccgcaagc  ggtgcggac  cgccttggt  gcgctgctg  300
tggcctgtg  cttgttggg  gtatgggga  agaaaagag  attcccacc  gcccaggcc  360
caccatctc  tctcgggac  aaagaagtt  tgacgccac  cactaagac  tcctggact  420
gaggttcca  ctccagtct  atgcgttcc  ccgcacctg  ggaggtgac  aaaggaggg  480
gggtggctg  agtcccgcc  agatccttc  ctcctccgt  ccaacgaaa  attgagatc  540
acaagactt  taaatacat  aacacgatt  tatcatgcc  cgtgttcgt  ctaggcatc  600
tcgggaact  cacactgct  agaatcatc  acaagaaca  gtgcatgag  aatggtccc  660
atatcttga  cgccagcct  gctctggga  atctgctac  catcatcat  gacattccc  720
ttaatgcct  caagctgct  gcaggggac  ggccatttg  agctgagat  tgcaagctg  780
tgcccttca  acagaaggc  tctgtgggg  tcacagtgt  gagtctatg  gctctaagt  840
ttgacagat  tcgagctgt  gcttcttgg  gtcgaatta  aggaattgg  gttccaaaa  900
ggacagcag  agaaattgt  ttaatttgg  tggtctctg  ggttctggc  gtccctgaa  960
ccataggtt  tgatgtgat  acgtcggac  acaaaggaa  gcccctaag  gtctgcatg  1020
ttaatccct  tcagaaaac  gccttcatg  agttttaca  gacagccaa  gactggtgg  1080
tgttcagtt  ctacttctg  ttgccgcta  ccatcactg  gatctttta  accctaatg  1140
cctgtgaga  gctcagaaa  aaaagtggt  tgcagattg  cttgaatga  cacttaaag  1200
agagacgag  agtggccaa  acagtattc  gcctggtcc  cgtgtttgc  ctctgttgg  1260
ttccccttc  cctcagcag  attctgaag  tcacccttt  tgaccagag  aatcctcag  1320
ggtgtgaac  tctgagttt  ttgctggtt  tggactaca  tggtatcaa  atggcttct  1380
tgaattcct  cattaatcc  atcgctctg  atttggtga  caagagatt  aaaaactgc  1440
ttaagtcgt  tttgtgctg  tggtgccaa  cgtttgagg  aaaacagtc  ttagaggag  1500
agcaatcct  cttgaagtt  aaagctaac  atcacggat  cgacaactt  cgctccagc  1560
ataaataca  ctcatcttg  aggaaggaa  actcactga  tctcattgt  ctcatcgtg  1620
acagatagc  ttaaaacaa  atgaaacct  tgccaaacc  aaacggaaa  ccgtgcttg  1680
ggaaaggtg  gcacgcatg  gagagggat  gttttttaa  cgttctaac  ttccacacc  1740
gatatttca  gggctgttt  caacctaag  aagccatgg  aatgaatga  gcctcggga  1800
agcacttag  ttcttagtc  gcacttcag  acggctctt  aaagccctc  ctgcactca  1860
agcccactt  catttaaaa  caagaactc  aactctatt  aggggttta  tatccagtc  1920
tatgaatct  gatacagga  tgcatgaca  tgcaaaaca  ttcttaaag  aaagtttca  1980
ttgctcgat  tgagacaaa  aacaaaaca  aaaaaaaa  2018



<210> 7657
<211> 442
<212> PRT
<213> Rattus norvegicus
<308> AAB28172
<400> 7657

Met Gln Ser Ser Ala Ser Arg Cys Gly Arg Ala Leu Val Ala Leu Leu 
  1               5                  10                  15
Leu Ala Cys Gly Leu Leu Gly Val Trp Gly Glu Lys Arg Gly Phe Pro 
             20                  25                  30
Pro Ala Gln Ala Thr Pro Ser Leu Leu Gly Thr Lys Glu Val Met Thr 
         35                  40                  45
Pro Pro Thr Lys Thr Ser Trp Thr Arg Gly Ser Asn Ser Ser Leu Met 
     50                  55                  60
Arg Ser Ser Ala Pro Ala Glu Val Thr Lys Gly Gly Arg Val Ala Gly 
 65                  70                  75                  80
Val Pro Pro Arg Ser Phe Pro Pro Pro Cys Gln Arg Lys Ile Glu Ile 
                 85                  90                  95
Asn Lys Thr Phe Lys Tyr Ile Asn Thr Ile Val Ser Cys Leu Val Phe 
             100                105                110
Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
         115                120                125
Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
     130                135                140
Leu Gly Asp Leu Leu His Ile Ile Ile Asp Ile Pro Ile Asn Ala Tyr 
 145                150                155                160
Lys Leu Leu Ala Gly Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                 165                170                175
Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
             180                185                190
Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
         195                200                205
Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
     210                215                220
Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
 225                230                235                240
Asp Val Ile Thr Ser Asp Tyr Lys Gly Lys Pro Leu Arg Val Cys Met 
                 245                250                255
Leu Asn Pro Phe Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
             260                265                270
Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
         275                280                285
Thr Ala Ile Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
     290                295                300
Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
 305                310                315                320
Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                 325                330                335
Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asp Gln 
             340                345                350
Ser Asn Pro Gln Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
         355                360                365
Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
     370                375                380
Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
 385                390                395                400
Leu Cys Cys Trp Cys Gln Thr Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                 405                410                415
Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
             420                425                430
Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
         435                440



<210> 7658
<211> 4286
<212> DNA
<213> Homo sapiens
<308> NM_000115
<400> 7658

gagacattc  ggtggggga  tctggccag  ccgagcaac  tggatcctg  gagcactcc  60
aggtaggca  ttgccccgg  gggacgcct  gccagagca  tgtgtggca  gcccccgtg  120
aggatcaac  cagtggctg  acactggga  ggaactggt  cttggagtc  ggacatctg  180
aacttggct  tgaaactgc  cagcggcca  cggacgcct  ctggagcag  tagcagcat  240
cagccgcct  caagtctgt  cggacgcgc  ctggttgcg  tggttcttg  ctgcggcct  300
tcgcggatc  ggggagagg  gagaggctt  ccgcctgac  gggccactc  gcttttgca  360
accgcagag  taatgacgc  acccactaa  accttatgg  ccaagggtt  caacgccag  420
ctggcgcgg  cgttggcac  tgcggaggt  cctaaagga  acaggacgg  aggatctcc  480
ccacgcacc  tctcccctc  cccgtgcca  ggacccatc  agatcaagg  gactttcaa  540
tacatcaac  cggttgtgt  ctgccttgt  ttcgtgctg  ggatcatcg  gaactccac  600
cttctgaga  ttatctaca  gaacaagtg  atgcgaaac  gtcccaata  cttgatcgc  660
agcttggct  tgggagacc  gctgcacat  gtcattgac  tccctatca  tgtctacaa  720
ctgctggca  aggactggc  atttggagc  gagatgtgt  agctggtgc  tttcataca  780
aaagcctcc  tgggaatca  tgtgctgag  ctatgtgct  tgagtattg  cagatatcg  840
gctgttgct  cttggagta  aattaaagg  attggggtt  caaaatgga  agcagtaga  900
attgttttg  tttgggtgg  ctctgtggt  ctggctgtc  ctgaagcca  aggttttga  960
ataattacg  tggactaca  aggaagtta  ctgcgaatc  gcttgcttc  tcccgttca  1020
aagacagct  tcatgcagt  ttacaagac  gcaaaagat  ggtggctgt  cagtttcta  1080
ttctgcttg  cattggcca  cactgcatt  ttttataca  taatgacct  tgaaatgtt  1140
agaaagaaa  gtggcatgc  gattgcttt  aatgatcac  taaagcaga  acgggaagt  1200
gccaaaacc  tcttttgcc  ggtccttgt  tttgccctc  gctggcttc  ccttcacct  1260
agcaggatt  tgaagctca  tctttataa  cagaatgat  ccaatagat  tgaactttt  1320
agctttctg  tggtattgg  ctatattgg  atcaacatg  cttcactga  ttcctgcat  1380
aacccaatt  ctctgtatt  ggtgagcaa  agattcaaa  actgcttta  gtcatgctt  1440
tgctgctgg  gccagtcat  tgaagaaaa  cagtccttg  aggaaaagc  gtcgtgctt  1500
aagttcaaa  ctaatgatc  cggatatga  aacttccgt  ccagtaata  atacagctc  1560
tcttgaaag  agaactatt  actgtattt  attttcttt  tattggacc  aagtcatta  1620
aacaaaatg  aacatttgc  aaaacaaaa  aaaaaacta  gtatttgca  agcacacta  1680
taaaatatt  agtgtaatt  ttttaacac  cacagctac  tatgacatt  tatgagctg  1740
ttacggcat  gaaagaaaa  cagtgggaa  taagaaagc  tcgtcgtga  agcacttaa  1800
tttttacag  tagcacttc  acatagctc  taacaactt  caggatatt  acacaacac  1860
taggcttaa  aatgagctc  ctcagaatt  ctattcttt  taaaaagag  tttattttt  1920
aatcaatgg  actctgata  aaaggaaga  taagtcact  taaaacaga  cttttaaat  1980
aagcttaaa  tactcaatt  aaaatttta  aatccttta  aacaacttt  caattaata  2040
tatcacact  ttatcagat  gtaattaga  gcaaatgag  gagcagttt  gttgttgca  2100
ttttcggac  ctggaaaca  ttaaatgat  aggagggag  aacagaaag  gcaaggctg  2160
ttttgaaaa  cattacact  tcactagaa  cccaaacct  agcattctg  aatatgtaa  2220
caacatgtc  caaacaagc  gcatgtaac  gactggcac  tgtgccagc  gaatttaaa  2280
tataatact  ttaaaaaga  aattattac  tcctttaca  tcagttaag  tcaaacctc  2340
caaagagaa  tagaatgtt  gaaaggcta  cccaaaaga  ttttttgaa  ctgtcattc  2400
cataccctg  gaagacaat  ctatctaca  ttttttcag  attattaaa  tcttctttt  2460
tcactatcg  agcttaaac  ctgtttggt  ttgtcatct  taaatactt  cctacatac  2520
ctgcatgta  atgattaaa  gagggcagg  cctgtgctc  tagctttac  atggagaga  2580
gccagtgac  tcataataa  gactgtgaa  tgcctggtg  agtgtccac  tgacaaagg  2640
gcaggtagc  ccctctctc  cccatgctg  ggttaaaat  gtttctagc  tatgtataa  2700
gctatagtt  aaatactat  tttcaaaat  atacagatt  gtacattta  cagctacct  2760
taaagctta  tactaattt  tgtattatt  ttgtaaata  ccaatagaa  agtttgctt  2820
acatggtgc  tttctttca  ctagaggca  aactgcttt  tgagaccgt  agaacctct  2880
agctttgtg  gttcctgcc  aatttttat  tcttctaag  aaagtgcct  aggatagct  2940
gggatgaga  gtgtgtgaa  gtatgtaca  gagaaaacg  aagagagag  aaatgaggt  3000
gggttggag  aaacccatg  ggacagatt  ccattctta  cctaacgtt  gtcattgcc  3060
cgtcacatc  atgcaaaag  tcctgattt  gttccagca  aacacagtg  aatgttctc  3120
gagtgactt  cgaaataaa  tgggcccaa  agctttaac  cggtcttaa  atatgccca  3180
atttttact  tgtttttct  ttaataggc  gggccacat  ttggaaata  gctagtaat  3240
ttgttttct  tcaatattg  atgtgatgg  acagtaaac  aaaacccaa  aatgtggcc  3300
gaaagaaag  gcaataata  ttaattcac  caccatatg  attctattt  taaatcacc  3360
acaaacttg  tctttaatt  catcccaat  actttttca  aggcctgtt  tcatagaag  3420
cattttaga  tctcaattt  aaattaatt  tgaatcact  atattttca  agtttatta  3480
tatatttaa  ttctattta  attttagat  atttttatt  ccatgtact  aatttttac  3540
tcctgatac  ctttccttc  ccatgtcag  atcatgttc  ctaattatc  tgccaaatt  3600
tgaaactac  cacaaaaag  atacttgca  tatttataa  aaaattgca  tcagtggct  3660
tttaaaaaa  atgtttgat  caaaacttt  acatactga  aagtaagaa  caattataa  3720
ttctttaca  actcaaaac  aagatagaa  aaggtgcta  cgttcaact  caaaacatg  3780
ttcctagta  taaggactt  aatatagca  cagacaaaa  tattgttaa  atggatgtt  3840
cagctcaaa  gatttataa  agattttaa  ctattttct  ccttattat  cactgctaa  3900
gtggatgta  gttcaaaca  cttttagta  tgatagctt  catatggcc  aaggaatac  3960
gtttatagc  aaacatggg  atgctgtag  taactttat  aaagtgtaa  ataacaatg  4020
aaaaaatta  atatctggg  ggatttttt  gttgcctaa  gtggctata  ttactgatt  4080
tttattatg  aagcaaaac  aataaaaat  taagttttt  taacaacta  cttattttt  4140
actgtacag  cactaattc  ttaaatact  attgattgt  taaaagaaa  ataaatgtg  4200
caagtggac  ttatttatg  taaatatac  attatcaag  aagtatgaa  ttattcaat  4260
aaaatgcca  atttctggt  tctggg  4286



<210> 7659
<211> 442
<212> PRT
<213> Homo sapiens
<308> P24530
<400> 7659

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
  1               5                  10                  15
Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
             20                  25                  30
Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
         35                  40                  45
Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
     50                  55                  60
Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
 65                  70                  75                  80
Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                 85                  90                  95
Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
             100                105                110
Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
         115                120                125
Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
     130                135                140
Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
 145                150                155                160
Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                 165                170                175
Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
             180                185                190
Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
         195                200                205
Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
     210                215                220
Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
 225                230                235                240
Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                 245                250                255
Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
             260                265                270
Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
         275                280                285
Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
     290                295                300
Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
 305                310                315                320
Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                 325                330                335
Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
             340                345                350
Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
         355                360                365
Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
     370                375                380
Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
 385                390                395                400
Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                 405                410                415
Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
             420                425                430
Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
         435                440



<210> 7661
<211> 274
<212> PRT
<213> Rattus norvegicus
<308> AAB28225
<400> 7661

Met Gly Thr Asp Ser Arg Ala Ala Gly Ala Leu Leu Ala Arg Ala Ser 
  1               5                  10                  15
Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 
             20                  25                  30
Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu Arg Asp Cys Ile Gln 
         35                  40                  45
Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Ser Pro Asp Leu Val Arg 
     50                  55                  60
Glu Phe Pro Asp Val Leu Glu Cys Thr Met Ser His Ala Val Glu Lys 
 65                  70                  75                  80
Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 
                 85                  90                  95
Ile Val Gly Ser Asn Ser Ser Ser Ser Thr Arg Asn Ala Val Asp Met 
             100                105                110
Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Met Ala 
         115                120                125
Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 
     130                135                140
Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 
 145                150                155                160
Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 
                 165                170                175
Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 
             180                185                190
Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 
         195                200                205
Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 
     210                215                220
Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Glu Ala Gln 
 225                230                235                240
Glu Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 
                 245                250                255
Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Lys 
             260                265                270
Gly Ser 
         275



<210> 7662
<211> 1610
<212> DNA
<213> Homo sapiens
<308> NM_002061
<400> 7662

ggcacgagg  tgcggccgc  gtagccgga  ccggagccg  agccaccgg  gccttcctt  1440
cccgccgcc  cccagccgc  gtccggcct  cctcgggcc  gagcgcaga  caggctcca  1500
ccgcgcggc  ccggcagcc  cgcgctccc  ctcgggtct  tctcgggcc  cgggcaccg  1560
gtcctgtgg  cggccgcct  cctgcccgc  cgcccgcag  cccttgcctg  1610



<210> 7663
<211> 274
<212> PRT
<213> Homo sapiens
<308> P48507
<400> 7663

Met Gly Thr Asp Ser Arg Ala Ala Lys Ala Leu Leu Ala Arg Ala Arg 
  1               5                  10                  15
Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 
             20                  25                  30
Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu His Asp Cys Ile Gln 
         35                  40                  45
Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Asn Pro Asp Leu Val Arg 
     50                  55                  60
Glu Phe Pro Asp Val Leu Glu Cys Thr Val Ser His Ala Val Glu Lys 
 65                  70                  75                  80
Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 
                 85                  90                  95
Ile Val Glu Ser Asn Ser Ser Ser Ser Thr Arg Ser Ala Val Asp Met 
             100                105                110
Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Ile Ala 
         115                120                125
Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 
     130                135                140
Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 
 145                150                155                160
Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 
                 165                170                175
Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 
             180                185                190
Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 
         195                200                205
Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 
     210                215                220
Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Gln Ala His 
 225                230                235                240
Glu Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 
                 245                250                255
Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Arg 
             260                265                270
Gly Ser 
         275



<210> 7665
<211> 274
<212> PRT
<213> Rattus norvegicus
<308> AAB28225
<400> 7665

Met Gly Thr Asp Ser Arg Ala Ala Gly Ala Leu Leu Ala Arg Ala Ser 
  1               5                  10                  15
Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 
             20                  25                  30
Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu Arg Asp Cys Ile Gln 
         35                  40                  45
Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Ser Pro Asp Leu Val Arg 
     50                  55                  60
Glu Phe Pro Asp Val Leu Glu Cys Thr Met Ser His Ala Val Glu Lys 
 65                  70                  75                  80
Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 
                 85                  90                  95
Ile Val Gly Ser Asn Ser Ser Ser Ser Thr Arg Asn Ala Val Asp Met 
             100                105                110
Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Met Ala 
         115                120                125
Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 
     130                135                140
Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 
 145                150                155                160
Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 
                 165                170                175
Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 
             180                185                190
Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 
         195                200                205
Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 
     210                215                220
Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Glu Ala Gln 
 225                230                235                240
Glu Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 
                 245                250                255
Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Lys 
             260                265                270
Gly Ser 
         275



<210> 7666
<211> 1610
<212> DNA
<213> Homo sapiens
<308> NM_002061
<400> 7666

ggcacgagg  tgcggccgc  gtagccgga  ccggagccg  agccaccgg  gccttcctt  1440
cccgccgcc  cccagccgc  gtccggcct  cctcgggcc  gagcgcaga  caggctcca  1500
ccgcgcggc  ccggcagcc  cgcgctccc  ctcgggtct  tctcgggcc  cgggcaccg  1560
gtcctgtgg  cggccgcct  cctgcccgc  cgcccgcag  cccttgcctg  1610



<210> 7667
<211> 274
<212> PRT
<213> Homo sapiens
<308> P48507
<400> 7667

Met Gly Thr Asp Ser Arg Ala Ala Lys Ala Leu Leu Ala Arg Ala Arg 
  1               5                  10                  15
Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 
             20                  25                  30
Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu His Asp Cys Ile Gln 
         35                  40                  45
Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Asn Pro Asp Leu Val Arg 
     50                  55                  60
Glu Phe Pro Asp Val Leu Glu Cys Thr Val Ser His Ala Val Glu Lys 
 65                  70                  75                  80
Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 
                 85                  90                  95
Ile Val Glu Ser Asn Ser Ser Ser Ser Thr Arg Ser Ala Val Asp Met 
             100                105                110
Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Ile Ala 
         115                120                125
Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 
     130                135                140
Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 
 145                150                155                160
Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 
                 165                170                175
Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 
             180                185                190
Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 
         195                200                205
Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 
     210                215                220
Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Gln Ala His 
 225                230                235                240
Glu Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 
                 245                250                255
Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Arg 
             260                265                270
Gly Ser 
         275



<210> 7669
<211> 274
<212> PRT
<213> Rattus norvegicus
<308> AAB28225
<400> 7669

Met Gly Thr Asp Ser Arg Ala Ala Gly Ala Leu Leu Ala Arg Ala Ser 
  1               5                  10                  15
Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 
             20                  25                  30
Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu Arg Asp Cys Ile Gln 
         35                  40                  45
Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Ser Pro Asp Leu Val Arg 
     50                  55                  60
Glu Phe Pro Asp Val Leu Glu Cys Thr Met Ser His Ala Val Glu Lys 
 65                  70                  75                  80
Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 
                 85                  90                  95
Ile Val Gly Ser Asn Ser Ser Ser Ser Thr Arg Asn Ala Val Asp Met 
             100                105                110
Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Met Ala 
         115                120                125
Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 
     130                135                140
Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 
 145                150                155                160
Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 
                 165                170                175
Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 
             180                185                190
Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 
         195                200                205
Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 
     210                215                220
Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Glu Ala Gln 
 225                230                235                240
Glu Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 
                 245                250                255
Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Lys 
             260                265                270
Gly Ser 
         275



<210> 7670
<211> 1610
<212> DNA
<213> Homo sapiens
<308> NM_002061
<400> 7670

ggcacgagg  tgcggccgc  gtagccgga  ccggagccg  agccaccgg  gccttcctt  1440
cccgccgcc  cccagccgc  gtccggcct  cctcgggcc  gagcgcaga  caggctcca  1500
ccgcgcggc  ccggcagcc  cgcgctccc  ctcgggtct  tctcgggcc  cgggcaccg  1560
gtcctgtgg  cggccgcct  cctgcccgc  cgcccgcag  cccttgcctg  1610



<210> 7671
<211> 274
<212> PRT
<213> Homo sapiens
<308> P48507
<400> 7671

Met Gly Thr Asp Ser Arg Ala Ala Lys Ala Leu Leu Ala Arg Ala Arg 
  1               5                  10                  15
Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 
             20                  25                  30
Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu His Asp Cys Ile Gln 
         35                  40                  45
Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Asn Pro Asp Leu Val Arg 
     50                  55                  60
Glu Phe Pro Asp Val Leu Glu Cys Thr Val Ser His Ala Val Glu Lys 
 65                  70                  75                  80
Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 
                 85                  90                  95
Ile Val Glu Ser Asn Ser Ser Ser Ser Thr Arg Ser Ala Val Asp Met 
             100                105                110
Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Ile Ala 
         115                120                125
Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 
     130                135                140
Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 
 145                150                155                160
Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 
                 165                170                175
Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 
             180                185                190
Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 
         195                200                205
Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 
     210                215                220
Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Gln Ala His 
 225                230                235                240
Glu Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 
                 245                250                255
Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Arg 
             260                265                270
Gly Ser 
         275



<210> 7673
<211> 274
<212> PRT
<213> Rattus norvegicus
<308> AAB28225
<400> 7673

Met Gly Thr Asp Ser Arg Ala Ala Gly Ala Leu Leu Ala Arg Ala Ser 
  1               5                  10                  15
Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 
             20                  25                  30
Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu Arg Asp Cys Ile Gln 
         35                  40                  45
Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Ser Pro Asp Leu Val Arg 
     50                  55                  60
Glu Phe Pro Asp Val Leu Glu Cys Thr Met Ser His Ala Val Glu Lys 
 65                  70                  75                  80
Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 
                 85                  90                  95
Ile Val Gly Ser Asn Ser Ser Ser Ser Thr Arg Asn Ala Val Asp Met 
             100                105                110
Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Met Ala 
         115                120                125
Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 
     130                135                140
Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 
 145                150                155                160
Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 
                 165                170                175
Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 
             180                185                190
Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 
         195                200                205
Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 
     210                215                220
Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Glu Ala Gln 
 225                230                235                240
Glu Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 
                 245                250                255
Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Lys 
             260                265                270
Gly Ser 
         275



<210> 7674
<211> 1610
<212> DNA
<213> Homo sapiens
<308> NM_002061
<400> 7674

ggcacgagg  tgcggccgc  gtagccgga  ccggagccg  agccaccgg  gccttcctt  1440
cccgccgcc  cccagccgc  gtccggcct  cctcgggcc  gagcgcaga  caggctcca  1500
ccgcgcggc  ccggcagcc  cgcgctccc  ctcgggtct  tctcgggcc  cgggcaccg  1560
gtcctgtgg  cggccgcct  cctgcccgc  cgcccgcag  cccttgcctg  1610



<210> 7675
<211> 274
<212> PRT
<213> Homo sapiens
<308> P48507
<400> 7675

Met Gly Thr Asp Ser Arg Ala Ala Lys Ala Leu Leu Ala Arg Ala Arg 
  1               5                  10                  15
Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 
             20                  25                  30
Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu His Asp Cys Ile Gln 
         35                  40                  45
Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Asn Pro Asp Leu Val Arg 
     50                  55                  60
Glu Phe Pro Asp Val Leu Glu Cys Thr Val Ser His Ala Val Glu Lys 
 65                  70                  75                  80
Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 
                 85                  90                  95
Ile Val Glu Ser Asn Ser Ser Ser Ser Thr Arg Ser Ala Val Asp Met 
             100                105                110
Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Ile Ala 
         115                120                125
Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 
     130                135                140
Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 
 145                150                155                160
Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 
                 165                170                175
Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 
             180                185                190
Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 
         195                200                205
Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 
     210                215                220
Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Gln Ala His 
 225                230                235                240
Glu Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 
                 245                250                255
Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Arg 
             260                265                270
Gly Ser 
         275



<210> 7676
<211> 436
<212> DNA
<213> Rattus norvegicus
<308> S66024
<400> 7676

actttattt  ggactgtgg  acggccaac  agaccactc  gtatgcaaa  gcccaacat  60
gctgtaact  gagatgaaa  tgatgagga  actgacctt  ccccaagtc  catggctgc  120
gccacaggt  acatgccaa  ttaccagat  cgagctcct  ctactgctt  gccacaagg  180
gtggtgatg  ctgcctcac  aggaagcct  cacagtccc  agcaactag  agaagaagc  240
actcgcaag  gggagctga  gctgatgaa  aacagggaa  ctgctaaag  atgtcgacg  300
cgaaagaaa  agtatgtca  gtgtcttga  agtcgagtc  cagtgctgg  agttcagaa  360
aagaagctt  tagaggagc  tgaaacttt  aaagacatt  gctctccca  aacagatta  420
tagaaatat  taacta  436



<210> 7677
<211> 120
<212> PRT
<213> Rattus norvegicus
<308> AAB28273
<400> 7677

Met Ala Val Thr Gly Asp Glu Thr Asp Glu Glu Thr Asp Leu Ala Pro 
  1               5                  10                  15
Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg 
             20                  25                  30
Ala Pro Thr Thr Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
         35                  40                  45
Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys 
     50                  55                  60
Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg 
 65                  70                  75                  80
Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val 
                 85                  90                  95
Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu Lys 
             100                105                110
Asp Ile Cys Ser Pro Lys Thr Asp 
         115                120



<210> 7678
<211> 363
<212> DNA
<213> Homo sapiens
<308> U44836
<400> 7678

atggctgta  ctggagatg  aactgatga  gaaactgaa  ttgccccaa  tcacatggc  60
gctgccact  gtgacatgc  aacttaccg  atccgagct  ctactgctg  tttgccaca  120
ggagtggtg  tggctgcat  gcccggaag  ttgcacagt  cccagcagc  ggcagaaga  180
gcaacacgc  aacgagagc  gaggctaat  aaaaacagg  aagctgcca  agaatgtcg  240
cgtcgaaag  aagaatatg  aaaatgtct  gagagccga  ttgcagtgc  ggaagtcca  300
aacaagaag  ttatagagg  acttgaaac  ttgaaagac  tttgctctc  caaaacaga  360
tag  363



<210> 7679
<211> 120
<212> PRT
<213> Homo sapiens
<308> AAB03751
<400> 7679

Met Ala Val Thr Gly Asp Glu Thr Asp Glu Glu Thr Glu Leu Ala Pro 
  1               5                  10                  15
Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Arg Ile Arg 
             20                  25                  30
Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
         35                  40                  45
Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys 
     50                  55                  60
Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg 
 65                  70                  75                  80
Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val 
                 85                  90                  95
Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu Lys 
             100                105                110
Asp Ile Cys Ser Pro Lys Thr Asp 
         115                120



<210> 7680
<211> 436
<212> DNA
<213> Rattus norvegicus
<308> S66024
<400> 7680

actttattt  ggactgtgg  acggccaac  agaccactc  gtatgcaaa  gcccaacat  60
gctgtaact  gagatgaaa  tgatgagga  actgacctt  ccccaagtc  catggctgc  120
gccacaggt  acatgccaa  ttaccagat  cgagctcct  ctactgctt  gccacaagg  180
gtggtgatg  ctgcctcac  aggaagcct  cacagtccc  agcaactag  agaagaagc  240
actcgcaag  gggagctga  gctgatgaa  aacagggaa  ctgctaaag  atgtcgacg  300
cgaaagaaa  agtatgtca  gtgtcttga  agtcgagtc  cagtgctgg  agttcagaa  360
aagaagctt  tagaggagc  tgaaacttt  aaagacatt  gctctccca  aacagatta  420
tagaaatat  taacta  436



<210> 7681
<211> 120
<212> PRT
<213> Rattus norvegicus
<308> AAB28273
<400> 7681

Met Ala Val Thr Gly Asp Glu Thr Asp Glu Glu Thr Asp Leu Ala Pro 
  1               5                  10                  15
Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg 
             20                  25                  30
Ala Pro Thr Thr Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
         35                  40                  45
Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys 
     50                  55                  60
Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg 
 65                  70                  75                  80
Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val 
                 85                  90                  95
Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu Lys 
             100                105                110
Asp Ile Cys Ser Pro Lys Thr Asp 
         115                120



<210> 7682
<211> 363
<212> DNA
<213> Homo sapiens
<308> U44836
<400> 7682

atggctgta  ctggagatg  aactgatga  gaaactgaa  ttgccccaa  tcacatggc  60
gctgccact  gtgacatgc  aacttaccg  atccgagct  ctactgctg  tttgccaca  120
ggagtggtg  tggctgcat  gcccggaag  ttgcacagt  cccagcagc  ggcagaaga  180
gcaacacgc  aacgagagc  gaggctaat  aaaaacagg  aagctgcca  agaatgtcg  240
cgtcgaaag  aagaatatg  aaaatgtct  gagagccga  ttgcagtgc  ggaagtcca  300
aacaagaag  ttatagagg  acttgaaac  ttgaaagac  tttgctctc  caaaacaga  360
tag  363



<210> 7683
<211> 120
<212> PRT
<213> Homo sapiens
<308> AAB03751
<400> 7683

Met Ala Val Thr Gly Asp Glu Thr Asp Glu Glu Thr Glu Leu Ala Pro 
  1               5                  10                  15
Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Arg Ile Arg 
             20                  25                  30
Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
         35                  40                  45
Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys 
     50                  55                  60
Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg 
 65                  70                  75                  80
Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val 
                 85                  90                  95
Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu Lys 
             100                105                110
Asp Ile Cys Ser Pro Lys Thr Asp 
         115                120



<210> 7684
<211> 253
<212> DNA
<213> Rattus norvegicus
<308> S66184
<400> 7684

agatttggt  tgataattg  tgacaattc  ccccatgct  ctttttctg  ggncagaaa  60
gtctaatgt  acgatcttc  cattaccat  acgaggant  ncaacacag  aaaatcatt  120
cgatgacag  tgtgataga  ggagagcta  catgcaact  ccgagtgtt  cactgttag  180
cagaactaa  tcactgccc  cacagcaat  acaccatga  tctctaaca  cacaacctt  240
tttcaaata  tgt  253



<210> 7685
<211> 411
<212> PRT
<213> Rattus norvegicus
<308> NP_058757
<400> 7685

Met Arg Phe Ala Trp Thr Val Leu Phe Leu Gly Gln Leu Gln Phe Cys 
  1               5                  10                  15
Pro Leu Leu Arg Cys Ala Pro Gln Ala Pro Arg Glu Pro Pro Ala Ala 
             20                  25                  30
Pro Gly Ala Trp Arg Gln Thr Ile Gln Trp Glu Asn Asn Gly Gln Val 
         35                  40                  45
Phe Ser Leu Leu Ser Leu Gly Ala Gln Tyr Gln Pro Gln Arg Arg Arg 
     50                  55                  60
Asp Ser Ser Ala Thr Ala Pro Arg Ala Asp Gly Asn Ala Ala Ala Gln 
 65                  70                  75                  80
Pro Arg Thr Pro Ile Leu Leu Leu Arg Asp Asn Arg Thr Ala Ser Ala 
                 85                  90                  95
Arg Ala Arg Thr Pro Ser Pro Ser Gly Val Ala Ala Gly Arg Pro Arg 
             100                105                110
Pro Ala Ala Arg His Trp Phe Gln Val Gly Phe Ser Pro Ser Gly Ala 
         115                120                125
Gly Asp Gly Ala Ser Arg Arg Ala Ala Asn Arg Thr Ala Ser Pro Gln 
     130                135                140
Pro Pro Gln Leu Ser Asn Leu Arg Pro Pro Ser His Val Asp Arg Met 
 145                150                155                160
Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys Tyr Ser Asp Asp Asn Pro 
                 165                170                175
Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg Pro Arg Ser Gly Ser Arg 
             180                185                190
His Arg Pro Gly Tyr Gly Thr Gly Tyr Phe Gln Tyr Gly Leu Pro Asp 
         195                200                205
Leu Val Pro Asp Pro Tyr Tyr Ile Gln Ala Ser Thr Tyr Val Gln Lys 
     210                215                220
Met Ser Met Tyr Asn Leu Arg Cys Ala Ala Glu Glu Asn Cys Leu Ala 
 225                230                235                240
Ser Ser Ala Tyr Arg Ala Asp Val Arg Asp Tyr Asp His Arg Val Leu 
                 245                250                255
Leu Arg Phe Pro Gln Arg Val Lys Asn Gln Gly Thr Ser Asp Phe Leu 
             260                265                270
Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp His Ser Cys His Gln His 
         275                280                285
Tyr His Ser Met Asp Glu Phe Ser His Tyr Asp Leu Leu Asp Ala Ser 
     290                295                300
Thr Gln Arg Arg Val Ala Glu Gly His Lys Ala Ser Phe Cys Leu Glu 
 305                310                315                320
Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg Arg Phe Ala Cys Thr Ala 
                 325                330                335
His Thr Gln Gly Leu Ser Pro Gly Cys Tyr Asp Thr Tyr Ala Ala Asp 
             340                345                350
Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp Val Gln Pro Gly Asn Tyr 
         355                360                365
Ile Leu Lys Val Ser Val Asn Pro Ser Tyr Leu Val Pro Glu Ser Asp 
     370                375                380
Tyr Ser Asn Asn Val Val Arg Cys Glu Ile Arg Tyr Thr Gly His His 
 385                390                395                400
Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro Tyr 
                 405                410



<210> 7686
<211> 1946
<212> DNA
<213> Homo sapiens
<308> NM_002317
<400> 7686

agacactgc  cgctctccg  gactccgcg  cgctccccg  tgccttcca  gactgagaa  60
ggggaaagg  aagggtgcc  cgtccgagc  gccgccttg  ctggggaag  gtctgaatc  120
cacccttgg  attgcttgg  ggagactga  atacccgtg  tccgctcgc  tccttggtt  180
aagatttct  cttccctca  gtgatttga  ccccgtttt  attttctgt  agccacgtc  240
tcctcgagc  gggtcaatc  ggcaaaagg  gtgatgcgc  tcgcctgga  cgtgctcct  300
ctcgggcct  tgcagctct  cgcgctagt  cactgcgcc  ctcccgccg  cggccaaca  360
cagcccccg  gcgagccgc  ggcggctcc  ggcgcctgg  gccagcaga  ccaatggga  420
aacaacggg  aggtgttca  cttgctgag  ctgggctca  agtaccagc  tcagcgccg  480
cgggacccg  gcgccgccg  ccctggtgc  gccaacgcc  ccgcccagc  gccccgcac  540
ccgatcctg  tgatccgcg  caaccgcac  gccgcggcg  gaacgcgga  ggccggctc  600
tctggagtc  ccgctggcc  ccccaggcc  accgcccgt  actggttcc  agctggcta  660
tcgacatct  gagcccgcg  agctggcgc  tcgcgcgcg  agaaccaga  agcgccggg  720
gaagttcct  cgctcagta  cctgcggcc  cccagccgc  tggacggca  ggtgggcga  780
gacccttac  acccctaca  gtactctga  gacaaccct  attacaact  ctacgatac  840
tatgaaagg  ccagacctg  gggcaggta  cggcccgga  acggcactg  ctacttcca  900
tacggtctc  cagacctgg  ggccgaccc  tactacatc  aggcgtcca  gtacgtgca  960
aagatgtcc  tgtacaacc  gagatgcgc  gcggaggaa  actgtctgg  cagtacagc  1020
tacagggca  atgtcagag  ttatgatca  agggtgctg  tcagatttc  ccaaagagt  1080
aaaaaccaa  ggacatcag  tttcttacc  agccgacca  gatattcct  ggaatggca  1140
agttgtcat  aacattacc  cagtatgga  gagtttagc  actatgacc  gcttgatgc  1200
aacacccag  ggagagtgg  tgaaggcca  aaagcaagt  tctgtcttg  agacacatc  1260
tgtgactat  gctaccaca  gcgatttgc  tgtactgca  acacacagg  attgagtcc  1320
ggctgttat  atacctatg  tgcagacat  gactgccag  ggattgata  tacagatgt  1380
aaacctgga  actatatcc  aaaggtcag  gtaaacccc  gctacctgg  tcctgaatc  1440
gactatacc  acaatgttg  gcgctgtga  attcgctac  caggacatc  tgcgtatgc  1500
tcaggctgc  caatttcac  gtattagaa  gcaaagcaa  actcccaat  gataaatca  1560
tgcctggtg  tctgaagtg  gaaaaaata  actaacttc  gtaggattt  tgtattttg  1620
aaaagagaa  agaaaacaa  aaaagaatt  ttgtttgga  tgttttcaa  aacaaagca  1680
ataactgga  tttgaacgc  taagtcatc  ttacttggg  aatttttaa  gtttattat  1740
tacatcact  tgtgaatta  cacagtgtt  caattctgt  attacatat  tgactcttt  1800
aaagaaatc  aaatttctc  tgttccttt  gaaattgta  tgcaaaatg  tcagtatta  1860
ctaaatgaa  gagccaaaa  gactttgaa  tgaaacttt  ctaaagtgc  ggaacttta  1920
tgaaacata  taataatgg  tttata  1946



<210> 7687
<211> 417
<212> PRT
<213> Homo sapiens
<308> P28300
<400> 7687

Met Arg Phe Ala Trp Thr Val Leu Leu Leu Gly Pro Leu Gln Leu Cys 
  1               5                  10                  15
Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro 
             20                  25                  30
Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp 
         35                  40                  45
Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr 
     50                  55                  60
Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala 
 65                  70                  75                  80
Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp 
                 85                  90                  95
Asn Arg Thr Ala Ala Ala Arg Thr Arg Thr Ala Gly Ser Ser Gly Val 
             100                105                110
Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly 
         115                120                125
Tyr Ser Thr Ser Arg Ala Arg Glu Ala Gly Ala Ser Arg Ala Glu Asn 
     130                135                140
Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro 
 145                150                155                160
Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
                 165                170                175
Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg 
             180                185                190
Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe 
         195                200                205
Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala 
     210                215                220
Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala 
 225                230                235                240
Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp 
                 245                250                255
Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln 
             260                265                270
Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp 
         275                280                285
His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr 
     290                295                300
Asp Leu Leu Asp Ala Asn Thr Gln Arg Arg Val Ala Glu Gly His Lys 
 305                310                315                320
Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg 
                 325                330                335
Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Tyr 
             340                345                350
Asp Thr Tyr Gly Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp 
         355                360                365
Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser Tyr 
     370                375                380
Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn Val Val Arg Cys Asp Ile 
 385                390                395                400
Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro 
                 405                410                415
Tyr 
             420



<210> 7688
<211> 433
<212> DNA
<213> Rattus norvegicus
<308> S68809
<400> 7688

accctcatc  atgtgttcc  tgcccactc  ggcaaggaa  gggacaaat  taagctgag  60
aagaaggag  tgaaagacc  gctacaaac  gaactctcc  gcttcctgg  tgtccagaa  120
gatgcagat  ctgtggaca  gatcatgaa  gaactggat  agaatggag  tggggaagt  180
gacttccag  agtttgttg  gctggtggc  gctctcacg  tggcttgta  caacttctt  240
tgggagaac  gttgagcac  gtctcagta  gcagcgccc  ccctctttt  ctcctcatc  300
cacctgtat  tccctatgt  cccatcctt  cccaggctc  acatgcacc  aaggcgcaa  360
agtagcagt  ctgccacta  ttttaataa  gcttctctc  cccgaaaaa  aaaaaaaaa  420
aaaaaaaaa  aaa  433



<210> 7689
<211> 93
<212> PRT
<213> Rattus norvegicus
<308> AAB20539
<400> 7689

Gly Ser Glu Leu Glu Thr Ala Met Glu Thr Leu Ile Asn Val Phe His 
  1               5                  10                  15
Ala His Ser Gly Lys Glu Gly Asp Lys Tyr Lys Leu Ser Lys Lys Glu 
             20                  25                  30
Leu Lys Asp Leu Leu Gln Thr Glu Leu Ser Ser Phe Leu Asp Val Gln 
         35                  40                  45
Lys Asp Ala Asp Ala Val Asp Lys Ile Met Lys Glu Leu Asp Glu Asn 
     50                  55                  60
Gly Asp Gly Glu Val Asp Phe Gln Glu Phe Val Val Leu Val Ala Ala 
 65                  70                  75                  80
Leu Thr Val Ala Cys Asn Asn Phe Phe Trp Glu Asn Ser 
                 85                  90



<210> 7690
<211> 607
<212> DNA
<213> Homo sapiens
<308> NM_006271
<400> 7690

ggactgttg  agacaggtc  ccacacaca  ctccagcag  cacatttgc  accttggcc  60
tctgtccag  acctgctcc  acctcaggc  caggccaac  gtgcactgc  gcaatgggc  120
ctgagctgg  gacggcgat  gagaccctc  tcaacgtgt  ccacgccca  tcgggcaaa  180
agggggaca  gtacaagct  agcaagaag  agctgaaag  gctgctgca  acggagctc  240
ctggcttcc  ggatgccca  aaggatgtg  atgctgtgg  caaggtgat  aaggagcta  300
acgagaatg  agacgggga  gtggacttc  aggagtatg  ggtgcttgt  gctgctctc  360
cagtggcct  taacaattt  ttctgggag  acagttgag  agacagcca  attgggcag  420
gcccttcct  tccaccctc  cagacctgc  tcttccccc  gcttccacc  caccccact  480
atccctctc  ataacccca  ccttgccca  cccaccccc  cccccacca  gggcgcaag  540
gtagcggtc  aagcctgca  ctcatcttt  attaaaggc  tctctctca  cagcaaaaa  600
aaaaaaa  607



<210> 7691
<211> 93
<212> PRT
<213> Homo sapiens
<308> P23297
<400> 7691

Gly Ser Glu Leu Glu Thr Ala Met Glu Thr Leu Ile Asn Val Phe His 
  1               5                  10                  15
Ala His Ser Gly Lys Glu Gly Asp Lys Tyr Lys Leu Ser Lys Lys Glu 
             20                  25                  30
Leu Lys Glu Leu Leu Gln Thr Glu Leu Ser Gly Phe Leu Asp Ala Gln 
         35                  40                  45
Lys Asp Val Asp Ala Val Asp Lys Val Met Lys Glu Leu Asp Glu Asn 
     50                  55                  60
Gly Asp Gly Glu Val Asp Phe Gln Glu Tyr Val Val Leu Val Ala Ala 
 65                  70                  75                  80
Leu Thr Val Ala Cys Asn Asn Phe Phe Trp Glu Asn Ser 
                 85                  90



<210> 7692
<211> 195
<212> DNA
<213> Rattus norvegicus
<308> S69316
<400> 7692

actctcact  tgaatcctg  gtggagagg  aatgtgaca  tttaaagtt  tttcttttg  60
gagacttgt  ttggatgct  ccccaagcc  ccctctccc  tgcactgta  aatgttggg  120
ttatgggtc  caggaagaa  tggtttttt  agttgaatt  tttttttta  cattcctcc  180
gaatgtaaa  ttgta  195



<210> 7693
<211> 802
<212> PRT
<213> Rattus norvegicus
<308> AAH10445
<400> 7693

Met Arg Val Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
  1               5                  10                  15
Gly Phe Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
             20                  25                  30
Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
         35                  40                  45
Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
     50                  55                  60
Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
 65                  70                  75                  80
Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                 85                  90                  95
Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
             100                105                110
Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ala Gly 
         115                120                125
Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
     130                135                140
Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
 145                150                155                160
Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                 165                170                175
Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
             180                185                190
Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
         195                200                205
Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
     210                215                220
Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
 225                230                235                240
Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                 245                250                255
Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Arg Lys Tyr Ser 
             260                265                270
Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
         275                280                285
Val Glu Glu Pro Leu Glu Glu Asp Glu Ala Ala Lys Glu Glu Lys Glu 
     290                295                300
Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
 305                310                315                320
Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                 325                330                335
Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
             340                345                350
Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
         355                360                365
Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
     370                375                380
Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
 385                390                395                400
Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                 405                410                415
Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
             420                425                430
Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
         435                440                445
Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
     450                455                460
Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Glu Lys Tyr 
 465                470                475                480
Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                 485                490                495
Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
             500                505                510
Gln Ser Ser His His Ser Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
         515                520                525
Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
     530                535                540
Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
 545                550                555                560
Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                 565                570                575
Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
             580                585                590
Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
         595                600                605
Glu Ala Thr Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
     610                615                620
Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
 625                630                635                640
Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                 645                650                655
Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
             660                665                670
Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
         675                680                685
Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
     690                695                700
Glu Asp Asp Lys Thr Val Met Asp Leu Ala Val Val Leu Phe Glu Thr 
 705                710                715                720
Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                 725                730                735
Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Glu 
             740                745                750
Ala Gln Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Asp Thr Ser Glu 
         755                760                765
Glu Ala Glu Asp Ser Glu Gln Asp Glu Gly Glu Glu Met Asp Ala Gly 
     770                775                780
Thr Glu Glu Glu Glu Glu Glu Thr Glu Lys Glu Ser Thr Glu Lys Asp 
 785                790                795                800
Glu Leu 
                 805



<210> 7694
<211> 1060
<212> DNA
<213> Rattus norvegicus
<308> S69329
<400> 7694

cagatatgg  agacatggg  gatccacca  aaaaaaaac  tctgatttc  ctatgtgtt  60
gttgcggta  tcaaattca  gatcagtat  ttctgaggg  ttctccgga  ttggaatgg  120
atgcggcat  tttgaaatg  gcggagtgt  atcagtatt  ggacgaaag  tgtacctgc  180
ttgttaggg  cgggaaaac  tactgtaaa  gagattata  caggttgta  gggatcaaa  240
gcgccaagt  cagcatagg  ttcagcaag  acgacttcg  gatgcgcgc  cgctctaag  300
tgtaccaca  cgaatgttt  cgctgtgta  catgcagcc  acagctcat  ccgggagac  360
aattcgcgc  gcgggagga  gggcttttc  gccgcgcgg  ccacgatgt  gtggagagg  420
ccagcctag  agctggaga  cctctcagt  ccttgcatc  agcgcggcc  ctgcaaatg  480
cagccgagc  catctccgc  aggcagcca  ctctgcggc  gcacgtcca  aaacagccc  540
agaagacca  ccgagtgcg  actgtgctc  acgaaaagc  gctgcacac  ttgcggacc  600
gctacgcag  caaccctcg  ccagatgcg  tcatgaagg  gcaactagt  gagatgacc  660
gcctcagtc  ccgagtcat  cgggtctgg  ttcaaaaca  gaggtgcaa  gacaagaaa  720
gcagcatca  gatgaagca  ctccagcag  agcaaccca  cgacaaaac  aatatccag  780
ggatgacag  aactcccat  gtggctgct  gtccggaga  acatgatgg  ggtttacag  840
ctaacccag  tgaggtgca  agttaccag  cgccctgga  agtactgag  gacttcgcc  900
tgcaaagtg  catagatca  cctgctttt  agcaactgg  caatttttc  gaaggagga  960
caggctcta  ttccactgg  agtgaagta  catcgatgt  ctctcagct  ccagataca  1020
ccaacagca  ggtagccag  cctatagag  catgaggaac  1060



<210> 7695
<211> 349
<212> PRT
<213> Rattus norvegicus
<308> AAB30128
<400> 7695

Met Gly Asp Met Gly Asp Pro Pro Lys Lys Lys Arg Leu Ile Ser Leu 
  1               5                  10                  15
Cys Val Gly Cys Gly Asn Gln Ile His Asp Gln Tyr Ile Leu Arg Val 
             20                  25                  30
Ser Pro Asp Leu Glu Trp His Ala Ala Cys Leu Lys Cys Ala Glu Cys 
         35                  40                  45
Asn Gln Tyr Leu Asp Glu Ser Cys Thr Cys Phe Val Arg Asp Gly Lys 
     50                  55                  60
Thr Tyr Cys Lys Arg Asp Tyr Ile Arg Leu Tyr Gly Ile Lys Cys Ala 
 65                  70                  75                  80
Lys Cys Ser Ile Gly Phe Ser Lys Asn Asp Phe Val Met Arg Ala Arg 
                 85                  90                  95
Ser Lys Val Tyr His Ile Glu Cys Phe Arg Cys Val Ala Cys Ser Arg 
             100                105                110
Gln Leu Ile Pro Gly Asp Glu Phe Ala Leu Arg Glu Asp Gly Leu Phe 
         115                120                125
Cys Arg Ala Asp His Asp Val Val Glu Arg Ala Ser Leu Gly Ala Gly 
     130                135                140
Asp Pro Leu Ser Pro Leu His Pro Ala Arg Pro Leu Gln Met Ala Ala 
 145                150                155                160
Glu Pro Ile Ser Ala Arg Gln Pro Ala Leu Arg Pro His Val His Lys 
                 165                170                175
Gln Pro Glu Lys Thr Thr Arg Val Arg Thr Val Leu Asn Glu Lys Gln 
             180                185                190
Leu His Thr Leu Arg Thr Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala 
         195                200                205
Leu Met Lys Glu Gln Leu Val Glu Met Thr Gly Leu Ser Pro Arg Val 
     210                215                220
Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys Arg Ser 
 225                230                235                240
Ile Met Met Lys Gln Leu Gln Gln Gln Gln Pro Asn Asp Lys Thr Asn 
                 245                250                255
Ile Gln Gly Met Thr Gly Thr Pro Met Val Ala Ala Ser Pro Glu Arg 
             260                265                270
His Asp Gly Gly Leu Gln Ala Asn Pro Val Glu Val Gln Ser Tyr Gln 
         275                280                285
Pro Pro Trp Lys Val Leu Ser Asp Phe Ala Leu Gln Ser Asp Ile Asp 
     290                295                300
Gln Pro Ala Phe Gln Gln Leu Val Asn Phe Ser Glu Gly Gly Pro Gly 
 305                310                315                320
Ser Asn Ser Thr Gly Ser Glu Val Ala Ser Met Ser Ser Gln Leu Pro 
                 325                330                335
Asp Thr Pro Asn Ser Met Val Ala Ser Pro Ile Glu Ala 
             340                345



<210> 7696
<211> 1060
<212> DNA
<213> Rattus norvegicus
<308> S69329
<400> 7696

cagatatgg  agacatggg  gatccacca  aaaaaaaac  tctgatttc  ctatgtgtt  60
gttgcggta  tcaaattca  gatcagtat  ttctgaggg  ttctccgga  ttggaatgg  120
atgcggcat  tttgaaatg  gcggagtgt  atcagtatt  ggacgaaag  tgtacctgc  180
ttgttaggg  cgggaaaac  tactgtaaa  gagattata  caggttgta  gggatcaaa  240
gcgccaagt  cagcatagg  ttcagcaag  acgacttcg  gatgcgcgc  cgctctaag  300
tgtaccaca  cgaatgttt  cgctgtgta  catgcagcc  acagctcat  ccgggagac  360
aattcgcgc  gcgggagga  gggcttttc  gccgcgcgg  ccacgatgt  gtggagagg  420
ccagcctag  agctggaga  cctctcagt  ccttgcatc  agcgcggcc  ctgcaaatg  480
cagccgagc  catctccgc  aggcagcca  ctctgcggc  gcacgtcca  aaacagccc  540
agaagacca  ccgagtgcg  actgtgctc  acgaaaagc  gctgcacac  ttgcggacc  600
gctacgcag  caaccctcg  ccagatgcg  tcatgaagg  gcaactagt  gagatgacc  660
gcctcagtc  ccgagtcat  cgggtctgg  ttcaaaaca  gaggtgcaa  gacaagaaa  720
gcagcatca  gatgaagca  ctccagcag  agcaaccca  cgacaaaac  aatatccag  780
ggatgacag  aactcccat  gtggctgct  gtccggaga  acatgatgg  ggtttacag  840
ctaacccag  tgaggtgca  agttaccag  cgccctgga  agtactgag  gacttcgcc  900
tgcaaagtg  catagatca  cctgctttt  agcaactgg  caatttttc  gaaggagga  960
caggctcta  ttccactgg  agtgaagta  catcgatgt  ctctcagct  ccagataca  1020
ccaacagca  ggtagccag  cctatagag  catgaggaac  1060



<210> 7697
<211> 349
<212> PRT
<213> Rattus norvegicus
<308> AAB30128
<400> 7697

Met Gly Asp Met Gly Asp Pro Pro Lys Lys Lys Arg Leu Ile Ser Leu 
  1               5                  10                  15
Cys Val Gly Cys Gly Asn Gln Ile His Asp Gln Tyr Ile Leu Arg Val 
             20                  25                  30
Ser Pro Asp Leu Glu Trp His Ala Ala Cys Leu Lys Cys Ala Glu Cys 
         35                  40                  45
Asn Gln Tyr Leu Asp Glu Ser Cys Thr Cys Phe Val Arg Asp Gly Lys 
     50                  55                  60
Thr Tyr Cys Lys Arg Asp Tyr Ile Arg Leu Tyr Gly Ile Lys Cys Ala 
 65                  70                  75                  80
Lys Cys Ser Ile Gly Phe Ser Lys Asn Asp Phe Val Met Arg Ala Arg 
                 85                  90                  95
Ser Lys Val Tyr His Ile Glu Cys Phe Arg Cys Val Ala Cys Ser Arg 
             100                105                110
Gln Leu Ile Pro Gly Asp Glu Phe Ala Leu Arg Glu Asp Gly Leu Phe 
         115                120                125
Cys Arg Ala Asp His Asp Val Val Glu Arg Ala Ser Leu Gly Ala Gly 
     130                135                140
Asp Pro Leu Ser Pro Leu His Pro Ala Arg Pro Leu Gln Met Ala Ala 
 145                150                155                160
Glu Pro Ile Ser Ala Arg Gln Pro Ala Leu Arg Pro His Val His Lys 
                 165                170                175
Gln Pro Glu Lys Thr Thr Arg Val Arg Thr Val Leu Asn Glu Lys Gln 
             180                185                190
Leu His Thr Leu Arg Thr Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala 
         195                200                205
Leu Met Lys Glu Gln Leu Val Glu Met Thr Gly Leu Ser Pro Arg Val 
     210                215                220
Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys Arg Ser 
 225                230                235                240
Ile Met Met Lys Gln Leu Gln Gln Gln Gln Pro Asn Asp Lys Thr Asn 
                 245                250                255
Ile Gln Gly Met Thr Gly Thr Pro Met Val Ala Ala Ser Pro Glu Arg 
             260                265                270
His Asp Gly Gly Leu Gln Ala Asn Pro Val Glu Val Gln Ser Tyr Gln 
         275                280                285
Pro Pro Trp Lys Val Leu Ser Asp Phe Ala Leu Gln Ser Asp Ile Asp 
     290                295                300
Gln Pro Ala Phe Gln Gln Leu Val Asn Phe Ser Glu Gly Gly Pro Gly 
 305                310                315                320
Ser Asn Ser Thr Gly Ser Glu Val Ala Ser Met Ser Ser Gln Leu Pro 
                 325                330                335
Asp Thr Pro Asn Ser Met Val Ala Ser Pro Ile Glu Ala 
             340                345



<210> 7698
<211> 2986
<212> DNA
<213> Rattus norvegicus
<308> S70011
<400> 7698

gtgctcctg  gggcggcgc  cgggaccgt  gcgcttccg  cagcgggag  cggcacgga  60
cgggaccga  aggcgcggg  ggcggccgg  gaggcggat  tgggacaat  tctggggaa  120
tgccaccca  cattaacat  aaggagcct  gatgggacc  gagcacgtt  attggccga  180
ccagtcact  cttcacggt  actgatccc  aaaacatcc  tttaacgaa  gaacagcta  240
agaatgcga  gaaagtggt  cacgattac  ggcaaggaa  cgttcctgc  ggcctcacg  300
aaaatgagt  atggagagc  aagtacgcg  atgactcgg  cttccatcc  gacacgggt  360
aaaagatga  tctgatagg  agaatgtcg  ctcaggtcc  gatgaacat  accatcacg  420
gctgcatga  gaccttcta  cggaccaca  cggctgtgc  tttctggca  tggataaac  480
agtccttca  tgccgtggt  aactacacc  atagaagtg  tgacgctcc  cttactgta  540
atgagctgg  aacggctta  gtttctgca  caaccggcg  cgtggcgac  gcccttgga  600
tcaatgccc  aaccaagca  gtgtcgccg  tgataggac  ttttgttcc  ttcgctgct  660
tagctgctg  taactgcat  aacatcccg  tgatgagac  aagggaact  aaggttggt  720
ttcctgtca  tgatgagaa  ggcacacgc  tgggagaat  gaccaacgc  gcaaagcaa  780
ccatcacgc  ggtggtcat  tccaggatc  tcatggcgg  ccctggcat  gccatccct  840
cgtttatca  gaacacctt  gagaagaaa  cctttttga  gaggttccc  tggatgagc  900
caccaattc  agtcacgct  gttggcttt  gtttggtgt  cgccacccc  ctgtgctgt  960
ctctgtttc  tcagaagag  tccatgtct  tgacaagct  ggaggatga  ttgcaagcc  1020
gcatccaaa  gagtcatcc  gaattacgg  gtgtgtact  taacaaggg  ctgtgaagc  1080
aagatcaag  gctggaggc  cctcctgcc  tctgtgaac  tcctgaagc  aagcagtga  1140
gaaatacgt  tgctgggca  tccccgcta  aaaagcctc  gcaaaatct  tgttagagt  1200
aagctgcct  tcaggagcc  gacatttga  tcatgttgt  atttacaaa  aataccctt  1260
tggtagatt  taatgatgc  gttttttcc  aagccccca  cttgagctt  caaaagctc  1320
ggtgggcat  gcatatatg  tccagttac  cactcagca  acactggtt  tcaatcatt  1380
gaaaggtta  cagctcaac  atcacattc  gtttctact  ctctccact  ggtctcagc  1440
atgaattgg  aacacaaag  tctaagaca  atatccaaa  ttaaatact  aggaaacta  1500
atctccagt  tggcaatgg  ccagtccaa  gtagaacct  aattaaaaa  attgaggtt  1560
agagcataa  cactccata  accttcctg  agtcagcca  agaccaggg  aggatgcct  1620
ccctgccat  ctggattct  caactcttc  atgtgttta  tgttcttaa  atattaatt  1680
tacctcaca  gtactttat  tcatgaatt  ccatcaaat  cttaactga  atggtctat  1740
cagtaccag  acaatgtga  attgactgg  tgaccggtt  ttcagaagt  aaaccatag  1800
ccctatatg  ctttttccc  ccatccttg  agaatttct  tggctttca  gaagatata  1860
agaaaccac  caaactagt  cagcaactg  gcacattgt  ctgcgttcc  ccctgtttg  1920
agaccatga  gtcttgtgg  atgtcaaca  ttctatggt  attttacat  tgacatatt  1980
ggtgtagct  aggttgctt  ggaagtctg  ggctattcc  cgtcataga  aagccactt  2040
ttacgctga  tgaaaaatc  ttgttaatt  agatatttg  acgtggaaa  aaaccccac  2100
aaaatagag  ctatctagt  tctgtagat  ctttttccc  atgtttcca  attgaattt  2160
ctcataaag  aaatatggt  tgccttgtg  ctgtgcttc  ccttcctct  aaaggatgg  2220
tggatctga  gcccccagc  ctcccccat  ctgctagaa  cttctgtgg  gatgaccgc  2280
aaaccacct  aaatgcagt  gctccctgt  gcactctgg  ctcggacga  cctcactgc  2340
ttcagtgct  ctgttttaa  cggtggtga  agcctggag  tcaaggcag  gtccacagg  2400
gcttaaaga  cactttcag  agaagctga  ggcctcgag  tctgttcat  aagccaatc  2460
cagagtcct  gccccagtg  gtgtgtagc  ctgagaatg  gaagactca  ttggaagat  2520
gtccaactc  ccaagtgtc  gcccagtta  tgagaaacg  gcagtagac  tggagctgg  2580
ctcttttga  tttgttttg  gaagtgtcg  cctcttact  cttttgtat  gtgatactc  2640
ctgtgtggt  taatcatga  ttataaaaa  aaaagaagc  aatgaatga  aattggcaa  2700
ctttgctga  cttctaaaa  tactttttt  tcctgaaga  aaaagccac  tgaagtgca  2760
taatgttgt  cggtgactt  ctgatagtt  tctgacgag  gatagttat  tgtgtgtga  2820
tggctggca  atatcagta  tagcgaggt  tcttgccaa  atcagagtc  gtgtgtcat  2880
tcagtttaa  tggatgaac  gtcaaataa  tgcagaatg  aaataaacg  ctcttattt  2940
tccgtgaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaa  2986



<210> 7699
<211> 322
<212> PRT
<213> Rattus norvegicus
<308> AAB30258
<400> 7699

Met Ser Gly Glu Val Pro Pro Asn Ile Asn Ile Lys Glu Pro Arg Trp 
  1               5                  10                  15
Asp Gln Ser Thr Phe Ile Gly Arg Ala Ser His Phe Phe Thr Val Thr 
             20                  25                  30
Asp Pro Lys Asn Ile Leu Leu Thr Asn Glu Gln Leu Glu Asn Ala Arg 
         35                  40                  45
Lys Val Val His Asp Tyr Arg Gln Gly Ile Val Pro Ala Gly Leu Thr 
     50                  55                  60
Glu Asn Glu Leu Trp Arg Ala Lys Tyr Ala Tyr Asp Ser Ala Phe His 
 65                  70                  75                  80
Pro Asp Thr Gly Glu Lys Met Thr Leu Ile Gly Arg Met Ser Ala Gln 
                 85                  90                  95
Val Pro Met Asn Met Thr Ile Thr Gly Cys Met Met Thr Phe Tyr Arg 
             100                105                110
Thr Thr Pro Ala Val Leu Phe Trp Gln Trp Ile Asn Gln Ser Phe Asn 
         115                120                125
Ala Val Val Asn Tyr Thr Asn Arg Ser Gly Asp Ala Pro Leu Thr Val 
     130                135                140
Asn Glu Leu Gly Thr Ala Tyr Val Ser Ala Thr Thr Gly Ala Val Ala 
 145                150                155                160
Thr Ala Leu Gly Leu Asn Ala Leu Thr Lys His Val Ser Pro Leu Ile 
                 165                170                175
Gly Arg Phe Val Pro Phe Ala Ala Val Ala Ala Ala Asn Cys Ile Asn 
             180                185                190
Ile Pro Leu Met Arg Gln Arg Glu Leu Lys Val Gly Ile Pro Val Thr 
         195                200                205
Asp Glu Asn Gly Thr Arg Leu Gly Glu Ser Thr Asn Ala Ala Lys Gln 
     210                215                220
Ala Ile Thr Gln Val Val Ile Ser Arg Ile Leu Met Ala Ala Pro Gly 
 225                230                235                240
Met Ala Ile Pro Pro Phe Ile Met Asn Thr Leu Glu Lys Lys Ala Phe 
                 245                250                255
Leu Lys Arg Phe Pro Trp Met Ser Ala Pro Ile Gln Val Thr Leu Val 
             260                265                270
Gly Phe Cys Leu Val Phe Ala Thr Pro Leu Cys Cys Ala Leu Phe Pro 
         275                280                285
Gln Lys Ser Ser Met Ser Val Thr Ser Leu Glu Asp Asp Leu Gln Ala 
     290                295                300
Ser Ile Gln Lys Ser His Pro Glu Leu Arg Arg Val Tyr Phe Asn Lys 
 305                310                315                320
Gly Leu 
                 325



<210> 7700
<211> 2735
<212> DNA
<213> Homo sapiens
<308> NM_030971
<400> 7700

ggagggccc  gcggcgaca  cggaggcag  gaggaaggc  gttctgaga  cttcagaga  60
cgatggaaa  caaaatggg  gaattgcct  tagacatca  catccagga  cctcgctgg  120
accaaagta  tttcctggg  agagcccgg  actttttca  tgttactga  cctcgaaat  180
tgctgctgt  cggggcaca  ctggaagct  ctcggaaca  cgtgcagaa  tacagggcc  240
gcgtggtga  cccagggat  accgaggac  agctgtgga  ggccaagta  gtgtatgac  300
ccgccttcc  tccggacac  ggggagaag  tggtcctga  tggccgcat  tcagcccag  360
tgcccatga  catgaccat  actggctgc  tgctcacat  ctacaggaa  accccaacc  420
tggtgttct  gcagtgggt  aatcagtcc  tcaatgcca  tgttaacta  tccaaccgc  480
gtggtgaca  tcccatcac  gtgaggcag  tggggacag  ctatgtgag  gccaccact  540
gagctgtgg  cacggccct  ggactcaaa  ccctcacca  gcacctgcc  cccttggtc  600
gcagatttg  gccctttgc  gcagtggca  ctgccaact  catcaacat  cccctgatg  660
ggcagagag  gctgcaggt  ggcatcccg  tggctgatg  ggcaggtca  aggcttggc  720
actcggtga  tgcagccaa  cagggaatc  tccaggtgg  gatttcaag  atctgcatg  780
cgattcctg  catggccat  ccaccactg  tcatggaca  tctggagaa  aaagacttc  840
tgaagcgcc  cccctggct  ggggcaccc  tgcaggtgg  actggtggg  ttctgcctg  900
tatttgcaa  ccccctgtg  tgtgcccta  tcccccaga  gagctccat  cacataagc  960
acctggaac  agagctgag  gctcagatc  atgagcaaa  ccccagcgt  gaagtggtc  1020
actacaaca  ggggctttg  ggagggtca  cctctgtcc  ctccctcac  tccttgggc  1080
gctgcttta  tggagtcat  tcaccccta  cacttggct  tctgcctag  actgggcag  1140
ggccttggt  ggcagatgg  aattgaggg  agcaaccta  tagggtggg  gagggacct  1200
cataaggct  ttcctccct  ctctggttt  aaagatcag  gcacataac  cctcctgtg  1260
ttgagtgtc  atgcatata  atacatgat  cacatgtgt  tgtgtacat  gggtcctga  1320
agctagaag  aggcatgct  gcctagtat  ttctgacat  tggcttccc  tctcagcct  1380
atgtccacc  gcctgccag  caggctaca  gtgtgactt  cttctctaa  ctgttacac  1440
agccaagtt  tttttgatg  cacctcatc  cttctagaa  taggaggag  cccaggatc  1500
caggacaga  acttataga  actagtagg  caaagcggg  tgaatcctt  aggtttctg  1560
tacctagct  cccaagctg  ctgggctgg  agaggagaa  atgttgaga  aagggaggc  1620
ggggactta  gcatccctc  gtgccatcc  ttgtatcct  gaatagctc  atttcccct  1680
ctcctctct  ccagacaaa  gagtgcctg  gtcctgtac  gccctcgct  tctccccca  1740
caccctact  gacagcgtg  gcatcttca  gcacagcct  gggagttcc  ggtgtgctc  1800
gacatcatg  cctcaaatc  aaatcctcc  atcccaact  cctttccca  acaaaaagc  1860
acagaggca  agcaagcat  cccctttaa  agcttccac  gcaccccct  ccaagggac  1920
cagcggtag  aatggtgct  aaactccac  ggtatcaga  agggtgtaa  taggacatc  1980
tcaagggca  ctaggcccc  aatgtacaa  gttaagaca  ggaattttg  gttccattg  2040
ctttttttt  tttttttaa  ggagtttca  tattttgcc  aggctggag  gcgatggtg  2100
gatcttggc  cactgcaac  tctgcctcc  gggttcaag  gattctctt  cctcagtct  2160
ccgagtagt  gaaattaca  gtgtgtgct  ccacatctt  ctagttttg  atttttagc  2220
gagatgggg  tttcaccat  ttggccagg  tagtctcga  ctcctgacc  caggtgatc  2280
acctgcctt  gcctcccaa  gcactggga  tacaagcat  agccactgt  cccagcctg  2340
tccactgac  tttcttaga  attcagcaa  acccccacc  taacctctt  tctttcttg  2400
gggttggtc  tgtccccac  tccaccctc  caccccctg  aagaggaag  gcccgggca  2460
cagtggcta  tccaaataa  atatgggct  ggggatgga  tgggtggtg  taagttcac  2520
gagtgtagt  agatcccaa  tcccatgac  tctggcttc  gtggtgggt  gggcagggc  2580
gatgaaagg  cttcagtgg  aacctctga  agcattttc  tgttccccc  atcaaccgc  2640
cccagtgat  acatctgtg  agccagcca  tactcaata  actgcaaac  tgtctaaaa  2700
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  2735



<210> 7701
<211> 321
<212> PRT
<213> Homo sapiens
<308> Q9BWM7
<400> 7701

Met Gly Glu Leu Pro Leu Asp Ile Asn Ile Gln Glu Pro Arg Trp Asp 
  1               5                  10                  15
Gln Ser Thr Phe Leu Gly Arg Ala Arg His Phe Phe Thr Val Thr Asp 
             20                  25                  30
Pro Arg Asn Leu Leu Leu Ser Gly Ala Gln Leu Glu Ala Ser Arg Asn 
         35                  40                  45
Ile Val Gln Asn Tyr Arg Ala Gly Val Val Thr Pro Gly Ile Thr Glu 
     50                  55                  60
Asp Gln Leu Trp Arg Ala Lys Tyr Val Tyr Asp Ser Ala Phe His Pro 
 65                  70                  75                  80
Asp Thr Gly Glu Lys Val Val Leu Ile Gly Arg Met Ser Ala Gln Val 
                 85                  90                  95
Pro Met Asn Met Thr Ile Thr Gly Cys Met Leu Thr Phe Tyr Arg Lys 
             100                105                110
Thr Pro Thr Val Val Phe Trp Gln Trp Val Asn Gln Ser Phe Asn Ala 
         115                120                125
Ile Val Asn Tyr Ser Asn Arg Ser Gly Asp Thr Pro Ile Thr Val Arg 
     130                135                140
Gln Leu Gly Thr Ala Tyr Val Ser Ala Thr Thr Gly Ala Val Ala Thr 
 145                150                155                160
Ala Leu Gly Leu Lys Ser Leu Thr Lys His Leu Pro Pro Leu Val Gly 
                 165                170                175
Arg Phe Val Pro Phe Ala Ala Val Ala Ala Ala Asn Cys Ile Asn Ile 
             180                185                190
Pro Leu Met Arg Gln Arg Glu Leu Gln Val Gly Ile Pro Val Ala Asp 
         195                200                205
Glu Ala Gly Gln Arg Leu Gly Tyr Ser Val Thr Ala Ala Lys Gln Gly 
     210                215                220
Ile Phe Gln Val Val Ile Ser Arg Ile Cys Met Ala Ile Pro Ala Met 
 225                230                235                240
Ala Ile Pro Pro Leu Ile Met Asp Thr Leu Glu Lys Lys Asp Phe Leu 
                 245                250                255
Lys Arg Arg Pro Trp Leu Gly Ala Pro Leu Gln Val Gly Leu Val Gly 
             260                265                270
Phe Cys Leu Val Phe Ala Thr Pro Leu Cys Cys Ala Leu Phe Pro Gln 
         275                280                285
Lys Ser Ser Ile His Ile Ser Asn Leu Glu Pro Glu Leu Arg Ala Gln 
     290                295                300
Ile His Glu Gln Asn Pro Ser Val Glu Val Val Tyr Tyr Asn Lys Gly 
 305                310                315                320
Leu 
                 325



<210> 7702
<211> 2986
<212> DNA
<213> Rattus norvegicus
<308> S70011
<400> 7702

gtgctcctg  gggcggcgc  cgggaccgt  gcgcttccg  cagcgggag  cggcacgga  60
cgggaccga  aggcgcggg  ggcggccgg  gaggcggat  tgggacaat  tctggggaa  120
tgccaccca  cattaacat  aaggagcct  gatgggacc  gagcacgtt  attggccga  180
ccagtcact  cttcacggt  actgatccc  aaaacatcc  tttaacgaa  gaacagcta  240
agaatgcga  gaaagtggt  cacgattac  ggcaaggaa  cgttcctgc  ggcctcacg  300
aaaatgagt  atggagagc  aagtacgcg  atgactcgg  cttccatcc  gacacgggt  360
aaaagatga  tctgatagg  agaatgtcg  ctcaggtcc  gatgaacat  accatcacg  420
gctgcatga  gaccttcta  cggaccaca  cggctgtgc  tttctggca  tggataaac  480
agtccttca  tgccgtggt  aactacacc  atagaagtg  tgacgctcc  cttactgta  540
atgagctgg  aacggctta  gtttctgca  caaccggcg  cgtggcgac  gcccttgga  600
tcaatgccc  aaccaagca  gtgtcgccg  tgataggac  ttttgttcc  ttcgctgct  660
tagctgctg  taactgcat  aacatcccg  tgatgagac  aagggaact  aaggttggt  720
ttcctgtca  tgatgagaa  ggcacacgc  tgggagaat  gaccaacgc  gcaaagcaa  780
ccatcacgc  ggtggtcat  tccaggatc  tcatggcgg  ccctggcat  gccatccct  840
cgtttatca  gaacacctt  gagaagaaa  cctttttga  gaggttccc  tggatgagc  900
caccaattc  agtcacgct  gttggcttt  gtttggtgt  cgccacccc  ctgtgctgt  960
ctctgtttc  tcagaagag  tccatgtct  tgacaagct  ggaggatga  ttgcaagcc  1020
gcatccaaa  gagtcatcc  gaattacgg  gtgtgtact  taacaaggg  ctgtgaagc  1080
aagatcaag  gctggaggc  cctcctgcc  tctgtgaac  tcctgaagc  aagcagtga  1140
gaaatacgt  tgctgggca  tccccgcta  aaaagcctc  gcaaaatct  tgttagagt  1200
aagctgcct  tcaggagcc  gacatttga  tcatgttgt  atttacaaa  aataccctt  1260
tggtagatt  taatgatgc  gttttttcc  aagccccca  cttgagctt  caaaagctc  1320
ggtgggcat  gcatatatg  tccagttac  cactcagca  acactggtt  tcaatcatt  1380
gaaaggtta  cagctcaac  atcacattc  gtttctact  ctctccact  ggtctcagc  1440
atgaattgg  aacacaaag  tctaagaca  atatccaaa  ttaaatact  aggaaacta  1500
atctccagt  tggcaatgg  ccagtccaa  gtagaacct  aattaaaaa  attgaggtt  1560
agagcataa  cactccata  accttcctg  agtcagcca  agaccaggg  aggatgcct  1620
ccctgccat  ctggattct  caactcttc  atgtgttta  tgttcttaa  atattaatt  1680
tacctcaca  gtactttat  tcatgaatt  ccatcaaat  cttaactga  atggtctat  1740
cagtaccag  acaatgtga  attgactgg  tgaccggtt  ttcagaagt  aaaccatag  1800
ccctatatg  ctttttccc  ccatccttg  agaatttct  tggctttca  gaagatata  1860
agaaaccac  caaactagt  cagcaactg  gcacattgt  ctgcgttcc  ccctgtttg  1920
agaccatga  gtcttgtgg  atgtcaaca  ttctatggt  attttacat  tgacatatt  1980
ggtgtagct  aggttgctt  ggaagtctg  ggctattcc  cgtcataga  aagccactt  2040
ttacgctga  tgaaaaatc  ttgttaatt  agatatttg  acgtggaaa  aaaccccac  2100
aaaatagag  ctatctagt  tctgtagat  ctttttccc  atgtttcca  attgaattt  2160
ctcataaag  aaatatggt  tgccttgtg  ctgtgcttc  ccttcctct  aaaggatgg  2220
tggatctga  gcccccagc  ctcccccat  ctgctagaa  cttctgtgg  gatgaccgc  2280
aaaccacct  aaatgcagt  gctccctgt  gcactctgg  ctcggacga  cctcactgc  2340
ttcagtgct  ctgttttaa  cggtggtga  agcctggag  tcaaggcag  gtccacagg  2400
gcttaaaga  cactttcag  agaagctga  ggcctcgag  tctgttcat  aagccaatc  2460
cagagtcct  gccccagtg  gtgtgtagc  ctgagaatg  gaagactca  ttggaagat  2520
gtccaactc  ccaagtgtc  gcccagtta  tgagaaacg  gcagtagac  tggagctgg  2580
ctcttttga  tttgttttg  gaagtgtcg  cctcttact  cttttgtat  gtgatactc  2640
ctgtgtggt  taatcatga  ttataaaaa  aaaagaagc  aatgaatga  aattggcaa  2700
ctttgctga  cttctaaaa  tactttttt  tcctgaaga  aaaagccac  tgaagtgca  2760
taatgttgt  cggtgactt  ctgatagtt  tctgacgag  gatagttat  tgtgtgtga  2820
tggctggca  atatcagta  tagcgaggt  tcttgccaa  atcagagtc  gtgtgtcat  2880
tcagtttaa  tggatgaac  gtcaaataa  tgcagaatg  aaataaacg  ctcttattt  2940
tccgtgaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaa  2986



<210> 7703
<211> 322
<212> PRT
<213> Rattus norvegicus
<308> AAB30258
<400> 7703

Met Ser Gly Glu Val Pro Pro Asn Ile Asn Ile Lys Glu Pro Arg Trp 
  1               5                  10                  15
Asp Gln Ser Thr Phe Ile Gly Arg Ala Ser His Phe Phe Thr Val Thr 
             20                  25                  30
Asp Pro Lys Asn Ile Leu Leu Thr Asn Glu Gln Leu Glu Asn Ala Arg 
         35                  40                  45
Lys Val Val His Asp Tyr Arg Gln Gly Ile Val Pro Ala Gly Leu Thr 
     50                  55                  60
Glu Asn Glu Leu Trp Arg Ala Lys Tyr Ala Tyr Asp Ser Ala Phe His 
 65                  70                  75                  80
Pro Asp Thr Gly Glu Lys Met Thr Leu Ile Gly Arg Met Ser Ala Gln 
                 85                  90                  95
Val Pro Met Asn Met Thr Ile Thr Gly Cys Met Met Thr Phe Tyr Arg 
             100                105                110
Thr Thr Pro Ala Val Leu Phe Trp Gln Trp Ile Asn Gln Ser Phe Asn 
         115                120                125
Ala Val Val Asn Tyr Thr Asn Arg Ser Gly Asp Ala Pro Leu Thr Val 
     130                135                140
Asn Glu Leu Gly Thr Ala Tyr Val Ser Ala Thr Thr Gly Ala Val Ala 
 145                150                155                160
Thr Ala Leu Gly Leu Asn Ala Leu Thr Lys His Val Ser Pro Leu Ile 
                 165                170                175
Gly Arg Phe Val Pro Phe Ala Ala Val Ala Ala Ala Asn Cys Ile Asn 
             180                185                190
Ile Pro Leu Met Arg Gln Arg Glu Leu Lys Val Gly Ile Pro Val Thr 
         195                200                205
Asp Glu Asn Gly Thr Arg Leu Gly Glu Ser Thr Asn Ala Ala Lys Gln 
     210                215                220
Ala Ile Thr Gln Val Val Ile Ser Arg Ile Leu Met Ala Ala Pro Gly 
 225                230                235                240
Met Ala Ile Pro Pro Phe Ile Met Asn Thr Leu Glu Lys Lys Ala Phe 
                 245                250                255
Leu Lys Arg Phe Pro Trp Met Ser Ala Pro Ile Gln Val Thr Leu Val 
             260                265                270
Gly Phe Cys Leu Val Phe Ala Thr Pro Leu Cys Cys Ala Leu Phe Pro 
         275                280                285
Gln Lys Ser Ser Met Ser Val Thr Ser Leu Glu Asp Asp Leu Gln Ala 
     290                295                300
Ser Ile Gln Lys Ser His Pro Glu Leu Arg Arg Val Tyr Phe Asn Lys 
 305                310                315                320
Gly Leu 
                 325



<210> 7704
<211> 2735
<212> DNA
<213> Homo sapiens
<308> NM_030971
<400> 7704

ggagggccc  gcggcgaca  cggaggcag  gaggaaggc  gttctgaga  cttcagaga  60
cgatggaaa  caaaatggg  gaattgcct  tagacatca  catccagga  cctcgctgg  120
accaaagta  tttcctggg  agagcccgg  actttttca  tgttactga  cctcgaaat  180
tgctgctgt  cggggcaca  ctggaagct  ctcggaaca  cgtgcagaa  tacagggcc  240
gcgtggtga  cccagggat  accgaggac  agctgtgga  ggccaagta  gtgtatgac  300
ccgccttcc  tccggacac  ggggagaag  tggtcctga  tggccgcat  tcagcccag  360
tgcccatga  catgaccat  actggctgc  tgctcacat  ctacaggaa  accccaacc  420
tggtgttct  gcagtgggt  aatcagtcc  tcaatgcca  tgttaacta  tccaaccgc  480
gtggtgaca  tcccatcac  gtgaggcag  tggggacag  ctatgtgag  gccaccact  540
gagctgtgg  cacggccct  ggactcaaa  ccctcacca  gcacctgcc  cccttggtc  600
gcagatttg  gccctttgc  gcagtggca  ctgccaact  catcaacat  cccctgatg  660
ggcagagag  gctgcaggt  ggcatcccg  tggctgatg  ggcaggtca  aggcttggc  720
actcggtga  tgcagccaa  cagggaatc  tccaggtgg  gatttcaag  atctgcatg  780
cgattcctg  catggccat  ccaccactg  tcatggaca  tctggagaa  aaagacttc  840
tgaagcgcc  cccctggct  ggggcaccc  tgcaggtgg  actggtggg  ttctgcctg  900
tatttgcaa  ccccctgtg  tgtgcccta  tcccccaga  gagctccat  cacataagc  960
acctggaac  agagctgag  gctcagatc  atgagcaaa  ccccagcgt  gaagtggtc  1020
actacaaca  ggggctttg  ggagggtca  cctctgtcc  ctccctcac  tccttgggc  1080
gctgcttta  tggagtcat  tcaccccta  cacttggct  tctgcctag  actgggcag  1140
ggccttggt  ggcagatgg  aattgaggg  agcaaccta  tagggtggg  gagggacct  1200
cataaggct  ttcctccct  ctctggttt  aaagatcag  gcacataac  cctcctgtg  1260
ttgagtgtc  atgcatata  atacatgat  cacatgtgt  tgtgtacat  gggtcctga  1320
agctagaag  aggcatgct  gcctagtat  ttctgacat  tggcttccc  tctcagcct  1380
atgtccacc  gcctgccag  caggctaca  gtgtgactt  cttctctaa  ctgttacac  1440
agccaagtt  tttttgatg  cacctcatc  cttctagaa  taggaggag  cccaggatc  1500
caggacaga  acttataga  actagtagg  caaagcggg  tgaatcctt  aggtttctg  1560
tacctagct  cccaagctg  ctgggctgg  agaggagaa  atgttgaga  aagggaggc  1620
ggggactta  gcatccctc  gtgccatcc  ttgtatcct  gaatagctc  atttcccct  1680
ctcctctct  ccagacaaa  gagtgcctg  gtcctgtac  gccctcgct  tctccccca  1740
caccctact  gacagcgtg  gcatcttca  gcacagcct  gggagttcc  ggtgtgctc  1800
gacatcatg  cctcaaatc  aaatcctcc  atcccaact  cctttccca  acaaaaagc  1860
acagaggca  agcaagcat  cccctttaa  agcttccac  gcaccccct  ccaagggac  1920
cagcggtag  aatggtgct  aaactccac  ggtatcaga  agggtgtaa  taggacatc  1980
tcaagggca  ctaggcccc  aatgtacaa  gttaagaca  ggaattttg  gttccattg  2040
ctttttttt  tttttttaa  ggagtttca  tattttgcc  aggctggag  gcgatggtg  2100
gatcttggc  cactgcaac  tctgcctcc  gggttcaag  gattctctt  cctcagtct  2160
ccgagtagt  gaaattaca  gtgtgtgct  ccacatctt  ctagttttg  atttttagc  2220
gagatgggg  tttcaccat  ttggccagg  tagtctcga  ctcctgacc  caggtgatc  2280
acctgcctt  gcctcccaa  gcactggga  tacaagcat  agccactgt  cccagcctg  2340
tccactgac  tttcttaga  attcagcaa  acccccacc  taacctctt  tctttcttg  2400
gggttggtc  tgtccccac  tccaccctc  caccccctg  aagaggaag  gcccgggca  2460
cagtggcta  tccaaataa  atatgggct  ggggatgga  tgggtggtg  taagttcac  2520
gagtgtagt  agatcccaa  tcccatgac  tctggcttc  gtggtgggt  gggcagggc  2580
gatgaaagg  cttcagtgg  aacctctga  agcattttc  tgttccccc  atcaaccgc  2640
cccagtgat  acatctgtg  agccagcca  tactcaata  actgcaaac  tgtctaaaa  2700
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  2735



<210> 7705
<211> 321
<212> PRT
<213> Homo sapiens
<308> Q9BWM7
<400> 7705

Met Gly Glu Leu Pro Leu Asp Ile Asn Ile Gln Glu Pro Arg Trp Asp 
  1               5                  10                  15
Gln Ser Thr Phe Leu Gly Arg Ala Arg His Phe Phe Thr Val Thr Asp 
             20                  25                  30
Pro Arg Asn Leu Leu Leu Ser Gly Ala Gln Leu Glu Ala Ser Arg Asn 
         35                  40                  45
Ile Val Gln Asn Tyr Arg Ala Gly Val Val Thr Pro Gly Ile Thr Glu 
     50                  55                  60
Asp Gln Leu Trp Arg Ala Lys Tyr Val Tyr Asp Ser Ala Phe His Pro 
 65                  70                  75                  80
Asp Thr Gly Glu Lys Val Val Leu Ile Gly Arg Met Ser Ala Gln Val 
                 85                  90                  95
Pro Met Asn Met Thr Ile Thr Gly Cys Met Leu Thr Phe Tyr Arg Lys 
             100                105                110
Thr Pro Thr Val Val Phe Trp Gln Trp Val Asn Gln Ser Phe Asn Ala 
         115                120                125
Ile Val Asn Tyr Ser Asn Arg Ser Gly Asp Thr Pro Ile Thr Val Arg 
     130                135                140
Gln Leu Gly Thr Ala Tyr Val Ser Ala Thr Thr Gly Ala Val Ala Thr 
 145                150                155                160
Ala Leu Gly Leu Lys Ser Leu Thr Lys His Leu Pro Pro Leu Val Gly 
                 165                170                175
Arg Phe Val Pro Phe Ala Ala Val Ala Ala Ala Asn Cys Ile Asn Ile 
             180                185                190
Pro Leu Met Arg Gln Arg Glu Leu Gln Val Gly Ile Pro Val Ala Asp 
         195                200                205
Glu Ala Gly Gln Arg Leu Gly Tyr Ser Val Thr Ala Ala Lys Gln Gly 
     210                215                220
Ile Phe Gln Val Val Ile Ser Arg Ile Cys Met Ala Ile Pro Ala Met 
 225                230                235                240
Ala Ile Pro Pro Leu Ile Met Asp Thr Leu Glu Lys Lys Asp Phe Leu 
                 245                250                255
Lys Arg Arg Pro Trp Leu Gly Ala Pro Leu Gln Val Gly Leu Val Gly 
             260                265                270
Phe Cys Leu Val Phe Ala Thr Pro Leu Cys Cys Ala Leu Phe Pro Gln 
         275                280                285
Lys Ser Ser Ile His Ile Ser Asn Leu Glu Pro Glu Leu Arg Ala Gln 
     290                295                300
Ile His Glu Gln Asn Pro Ser Val Glu Val Val Tyr Tyr Asn Lys Gly 
 305                310                315                320
Leu 
                 325



<210> 7706
<211> 737
<212> DNA
<213> Rattus norvegicus
<308> S70803
<400> 7706

cgtcagcca  caacccccg  gtctgcacc  tcgtctgga  tcttaacac  gacctcaag  60
gccgcctgc  tcggtaccc  atccaccag  gccttgggc  accatgttt  aatttgcct  120
ttacctgcg  cacgtgttg  agagcctgg  cgcccgagc  gaccatgtt  cctcgccac  180
ctgcggcca  ggtcctgtc  acagcctct  gagccagaa  gtggaaatg  ttgggtttc  240
gctgcccat  aaggacttt  tgctaagca  gcccgtgcg  cctccttcc  tggctgtag  300
ttccactaa  ccacactgc  cggaacagg  ccctgagcg  ttgtggggt  gagtacctg  360
actcggggt  ccatactgg  ggagccggg  ctgtcttgc  tatgctgac  tacagctcc  420
gccttctgg  gaggagacc  ccgccatgc  tcactgggc  ccttagact  ggtcacaga  480
gactgggcc  gggtagggc  ggagaccat  ccgttgcaa  gtgaaggtg  ggaagccct  540
tagtccagg  tttgtacca  tagggaagg  gtctgggac  gttccatac  cactgtggg  600
atgtaaggc  gggggacag  attgccttc  tgcctctcc  cgccttctc  ggaaccttt  660
taataaatt  agccaatta  aaacacaaa  taaagaatc  aaatgcaaa  aaaaaaaca  720
aaaaaaaaa  aaaaaaa  737



<210> 7707
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> AAB30888
<400> 7707

His Arg Pro Gln Gly Pro Pro Ala Ser Val Pro His Pro Pro Glu Pro 
  1               5                  10                  15
Trp Ala Thr Met Phe Glu Phe Ala Phe Tyr Leu Arg His Val Leu Glu 
             20                  25                  30
Ser Leu Gly Ala Arg Ala Asp His Val Pro Ser Pro Pro Cys Gly Gln 
         35                  40                  45
Gly Pro Val His Ser Leu Trp Ser Gln Lys Val Glu Met Phe Gly Phe 
     50                  55                  60
Leu Leu Pro Met Lys Asp Phe Val Leu Ser Arg Pro Val Arg Pro Pro 
 65                  70                  75                  80
Ser Met Ala Val Ala Ser Thr Lys Pro His Cys Ser Glu Gln Gly Pro 
                 85                  90                  95
Glu Arg Leu Trp Gly 
             100



<210> 7708
<211> 737
<212> DNA
<213> Rattus norvegicus
<308> S70803
<400> 7708

cgtcagcca  caacccccg  gtctgcacc  tcgtctgga  tcttaacac  gacctcaag  60
gccgcctgc  tcggtaccc  atccaccag  gccttgggc  accatgttt  aatttgcct  120
ttacctgcg  cacgtgttg  agagcctgg  cgcccgagc  gaccatgtt  cctcgccac  180
ctgcggcca  ggtcctgtc  acagcctct  gagccagaa  gtggaaatg  ttgggtttc  240
gctgcccat  aaggacttt  tgctaagca  gcccgtgcg  cctccttcc  tggctgtag  300
ttccactaa  ccacactgc  cggaacagg  ccctgagcg  ttgtggggt  gagtacctg  360
actcggggt  ccatactgg  ggagccggg  ctgtcttgc  tatgctgac  tacagctcc  420
gccttctgg  gaggagacc  ccgccatgc  tcactgggc  ccttagact  ggtcacaga  480
gactgggcc  gggtagggc  ggagaccat  ccgttgcaa  gtgaaggtg  ggaagccct  540
tagtccagg  tttgtacca  tagggaagg  gtctgggac  gttccatac  cactgtggg  600
atgtaaggc  gggggacag  attgccttc  tgcctctcc  cgccttctc  ggaaccttt  660
taataaatt  agccaatta  aaacacaaa  taaagaatc  aaatgcaaa  aaaaaaaca  720
aaaaaaaaa  aaaaaaa  737



<210> 7709
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> AAB30888
<400> 7709

His Arg Pro Gln Gly Pro Pro Ala Ser Val Pro His Pro Pro Glu Pro 
  1               5                  10                  15
Trp Ala Thr Met Phe Glu Phe Ala Phe Tyr Leu Arg His Val Leu Glu 
             20                  25                  30
Ser Leu Gly Ala Arg Ala Asp His Val Pro Ser Pro Pro Cys Gly Gln 
         35                  40                  45
Gly Pro Val His Ser Leu Trp Ser Gln Lys Val Glu Met Phe Gly Phe 
     50                  55                  60
Leu Leu Pro Met Lys Asp Phe Val Leu Ser Arg Pro Val Arg Pro Pro 
 65                  70                  75                  80
Ser Met Ala Val Ala Ser Thr Lys Pro His Cys Ser Glu Gln Gly Pro 
                 85                  90                  95
Glu Arg Leu Trp Gly 
             100



<210> 7710
<211> 737
<212> DNA
<213> Rattus norvegicus
<308> S70803
<400> 7710

cgtcagcca  caacccccg  gtctgcacc  tcgtctgga  tcttaacac  gacctcaag  60
gccgcctgc  tcggtaccc  atccaccag  gccttgggc  accatgttt  aatttgcct  120
ttacctgcg  cacgtgttg  agagcctgg  cgcccgagc  gaccatgtt  cctcgccac  180
ctgcggcca  ggtcctgtc  acagcctct  gagccagaa  gtggaaatg  ttgggtttc  240
gctgcccat  aaggacttt  tgctaagca  gcccgtgcg  cctccttcc  tggctgtag  300
ttccactaa  ccacactgc  cggaacagg  ccctgagcg  ttgtggggt  gagtacctg  360
actcggggt  ccatactgg  ggagccggg  ctgtcttgc  tatgctgac  tacagctcc  420
gccttctgg  gaggagacc  ccgccatgc  tcactgggc  ccttagact  ggtcacaga  480
gactgggcc  gggtagggc  ggagaccat  ccgttgcaa  gtgaaggtg  ggaagccct  540
tagtccagg  tttgtacca  tagggaagg  gtctgggac  gttccatac  cactgtggg  600
atgtaaggc  gggggacag  attgccttc  tgcctctcc  cgccttctc  ggaaccttt  660
taataaatt  agccaatta  aaacacaaa  taaagaatc  aaatgcaaa  aaaaaaaca  720
aaaaaaaaa  aaaaaaa  737



<210> 7711
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> AAB30888
<400> 7711

His Arg Pro Gln Gly Pro Pro Ala Ser Val Pro His Pro Pro Glu Pro 
  1               5                  10                  15
Trp Ala Thr Met Phe Glu Phe Ala Phe Tyr Leu Arg His Val Leu Glu 
             20                  25                  30
Ser Leu Gly Ala Arg Ala Asp His Val Pro Ser Pro Pro Cys Gly Gln 
         35                  40                  45
Gly Pro Val His Ser Leu Trp Ser Gln Lys Val Glu Met Phe Gly Phe 
     50                  55                  60
Leu Leu Pro Met Lys Asp Phe Val Leu Ser Arg Pro Val Arg Pro Pro 
 65                  70                  75                  80
Ser Met Ala Val Ala Ser Thr Lys Pro His Cys Ser Glu Gln Gly Pro 
                 85                  90                  95
Glu Arg Leu Trp Gly 
             100



<210> 7712
<211> 737
<212> DNA
<213> Rattus norvegicus
<308> S70803
<400> 7712

cgtcagcca  caacccccg  gtctgcacc  tcgtctgga  tcttaacac  gacctcaag  60
gccgcctgc  tcggtaccc  atccaccag  gccttgggc  accatgttt  aatttgcct  120
ttacctgcg  cacgtgttg  agagcctgg  cgcccgagc  gaccatgtt  cctcgccac  180
ctgcggcca  ggtcctgtc  acagcctct  gagccagaa  gtggaaatg  ttgggtttc  240
gctgcccat  aaggacttt  tgctaagca  gcccgtgcg  cctccttcc  tggctgtag  300
ttccactaa  ccacactgc  cggaacagg  ccctgagcg  ttgtggggt  gagtacctg  360
actcggggt  ccatactgg  ggagccggg  ctgtcttgc  tatgctgac  tacagctcc  420
gccttctgg  gaggagacc  ccgccatgc  tcactgggc  ccttagact  ggtcacaga  480
gactgggcc  gggtagggc  ggagaccat  ccgttgcaa  gtgaaggtg  ggaagccct  540
tagtccagg  tttgtacca  tagggaagg  gtctgggac  gttccatac  cactgtggg  600
atgtaaggc  gggggacag  attgccttc  tgcctctcc  cgccttctc  ggaaccttt  660
taataaatt  agccaatta  aaacacaaa  taaagaatc  aaatgcaaa  aaaaaaaca  720
aaaaaaaaa  aaaaaaa  737



<210> 7713
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> AAB30888
<400> 7713

His Arg Pro Gln Gly Pro Pro Ala Ser Val Pro His Pro Pro Glu Pro 
  1               5                  10                  15
Trp Ala Thr Met Phe Glu Phe Ala Phe Tyr Leu Arg His Val Leu Glu 
             20                  25                  30
Ser Leu Gly Ala Arg Ala Asp His Val Pro Ser Pro Pro Cys Gly Gln 
         35                  40                  45
Gly Pro Val His Ser Leu Trp Ser Gln Lys Val Glu Met Phe Gly Phe 
     50                  55                  60
Leu Leu Pro Met Lys Asp Phe Val Leu Ser Arg Pro Val Arg Pro Pro 
 65                  70                  75                  80
Ser Met Ala Val Ala Ser Thr Lys Pro His Cys Ser Glu Gln Gly Pro 
                 85                  90                  95
Glu Arg Leu Trp Gly 
             100



<210> 7714
<211> 1764
<212> DNA
<213> Rattus norvegicus
<308> S71570
<400> 7714

atggagacc  ccgccacct  cacccgctt  accgacgac  accagcttt  cgaggagct  60
ggcaagggt  ccttctcgg  ggtccggag  tgcgtgaag  aaacgtcga  gcaggagta  120
gcagcaaaa  tcatcaata  caagaagtt  tctgcccga  atcatcaga  actagaacg  180
gaggcccgg  tatgccgac  tctgaaaca  ccaaacatc  tgcgtctcc  tgacagtat  240
tctgaagaa  ggtttcact  cctcgtgtt  gaccttgtt  cgggagggg  gttgtttga  300
gacatcgtg  ccagagaat  ctacagcga  gctgatgcc  gccactgta  acatcagat  360
ctggagagc  tcaaccaca  ccaccagca  gacatcgtc  accgggacc  gaagcccga  420
aacttgctg  tggcgagta  atgcaaggg  gctgcggtc  agctagctg  ttttggcct  480
gccatcgaa  tgcagggag  gcagcaggc  tggtttggt  ttgctggca  cccaggtta  540
ttgtcccct  aggtcttga  gaaagatcc  tatggaaaa  ctgtggata  ctgggcctg  600
ggggtcatc  tgtatatcc  cctggtggg  taccctccc  tctgggatg  ggatcagca  660
aagctctat  agcagatca  agctggagc  tacgatttc  catcaccag  atgggacac  720
gtcactcct  aagctaaga  cttgatcaa  cagatgttg  ccataaacc  tgcaaagcg  780
atcacagct  accaggctc  caagcaccc  tgggtctgt  aacggtcaa  agtggcatc  840
atgatgcat  gccaagaga  agtggagtg  ttacgcaag  tcaacgccc  gagaaaact  900
aagggtgcc  tcctcacaa  catgcttgt  tccaggaac  tttcagctg  caagagcct  960
ttgaacaag  agtcagatg  cggcgtcaa  ccagagcaa  aacaaaaac  gtctcgtaa  1020
cccagccca  gagcccgcg  tcccttgca  acggccatg  agccacaaa  caccgtggt  1080
cataatgct  cagatggga  caagggctc  acagagagc  gcaacacca  cacagaaga  1140
gaagatctc  aagtgcgaa  acaggagat  attaagatc  cagaacagc  gatagaagc  1200
atcaacaat  gggactttg  ggcctacac  aagatttgt  acccaggcc  cacttcctt  1260
gagccagaa  cccttggta  cctcgtgga  gggatggat  tccataagt  ttactttga  1320
aatctcctg  ccaagaaca  caagcctat  cacaccacc  tcctaaacc  acatgtcca  1380
gtcatcggc  aggacgcag  ttgcatcgc  tacatccgg  tcacccagt  catcgatgg  1440
cagggtcgg  ctcgcacca  tcagtcaga  gagacccgg  tgtggcacc  ccgggatgg  1500
aagtggctc  atgtccact  tcactgctc  ggagcccct  ctgcaccgc  gcagtgagc  1560
caggcacag  ggcattagg  gattccagc  ggaggctga  ccttcgaag  cagtgactc  1620
ggagggcct  agtgacagc  gcggtcctg  ccatttgag  tttaaacaa  tacattaca  1680
agcgcagca  ccaatgacg  ccctgcatg  agccctccc  cccgccctt  gtgtctgtc  1740
ctgctgtac  gaggtgttt  ttac  1764



<210> 7715
<211> 527
<212> PRT
<213> Rattus norvegicus
<308> AAB30670
<400> 7715

Met Ala Thr Thr Ala Thr Cys Thr Arg Phe Thr Asp Asp Tyr Gln Leu 
  1               5                  10                  15
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
             20                  25                  30
Lys Lys Thr Ser Thr Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
         115                120                125
Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
             180                185                190
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala Asp Gln Ala Leu Lys His Pro Trp Val 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Val Ser Arg Asn Phe Ser Val Gly Arg Gln Ser 
 305                310                315                320
Ser Ala Pro Ala Ser Pro Ala Ala Ser Ala Ala Gly Leu Ala Gly Gln 
                 325                330                335
Ala Ala Lys Ser Leu Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Lys 
             340                345                350
Arg Lys Ser Ser Ser Ser Val His Leu Met Glu Pro Gln Thr Thr Val 
         355                360                365
Val His Asn Ala Thr Asp Gly Ile Lys Gly Ser Thr Glu Ser Cys Asn 
     370                375                380
Thr Thr Thr Glu Asp Glu Asp Leu Lys Val Arg Lys Gln Glu Ile Ile 
 385                390                395                400
Lys Ile Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu 
                 405                410                415
Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu 
             420                425                430
Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe 
         435                440                445
Glu Asn Leu Leu Ser Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu 
     450                455                460
Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr 
 465                470                475                480
Ile Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser 
                 485                490                495
Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu 
             500                505                510
Asn Val His Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln 
         515                520                525



<210> 7716
<211> 1764
<212> DNA
<213> Rattus norvegicus
<308> S71570
<400> 7716

atggagacc  ccgccacct  cacccgctt  accgacgac  accagcttt  cgaggagct  60
ggcaagggt  ccttctcgg  ggtccggag  tgcgtgaag  aaacgtcga  gcaggagta  120
gcagcaaaa  tcatcaata  caagaagtt  tctgcccga  atcatcaga  actagaacg  180
gaggcccgg  tatgccgac  tctgaaaca  ccaaacatc  tgcgtctcc  tgacagtat  240
tctgaagaa  ggtttcact  cctcgtgtt  gaccttgtt  cgggagggg  gttgtttga  300
gacatcgtg  ccagagaat  ctacagcga  gctgatgcc  gccactgta  acatcagat  360
ctggagagc  tcaaccaca  ccaccagca  gacatcgtc  accgggacc  gaagcccga  420
aacttgctg  tggcgagta  atgcaaggg  gctgcggtc  agctagctg  ttttggcct  480
gccatcgaa  tgcagggag  gcagcaggc  tggtttggt  ttgctggca  cccaggtta  540
ttgtcccct  aggtcttga  gaaagatcc  tatggaaaa  ctgtggata  ctgggcctg  600
ggggtcatc  tgtatatcc  cctggtggg  taccctccc  tctgggatg  ggatcagca  660
aagctctat  agcagatca  agctggagc  tacgatttc  catcaccag  atgggacac  720
gtcactcct  aagctaaga  cttgatcaa  cagatgttg  ccataaacc  tgcaaagcg  780
atcacagct  accaggctc  caagcaccc  tgggtctgt  aacggtcaa  agtggcatc  840
atgatgcat  gccaagaga  agtggagtg  ttacgcaag  tcaacgccc  gagaaaact  900
aagggtgcc  tcctcacaa  catgcttgt  tccaggaac  tttcagctg  caagagcct  960
ttgaacaag  agtcagatg  cggcgtcaa  ccagagcaa  aacaaaaac  gtctcgtaa  1020
cccagccca  gagcccgcg  tcccttgca  acggccatg  agccacaaa  caccgtggt  1080
cataatgct  cagatggga  caagggctc  acagagagc  gcaacacca  cacagaaga  1140
gaagatctc  aagtgcgaa  acaggagat  attaagatc  cagaacagc  gatagaagc  1200
atcaacaat  gggactttg  ggcctacac  aagatttgt  acccaggcc  cacttcctt  1260
gagccagaa  cccttggta  cctcgtgga  gggatggat  tccataagt  ttactttga  1320
aatctcctg  ccaagaaca  caagcctat  cacaccacc  tcctaaacc  acatgtcca  1380
gtcatcggc  aggacgcag  ttgcatcgc  tacatccgg  tcacccagt  catcgatgg  1440
cagggtcgg  ctcgcacca  tcagtcaga  gagacccgg  tgtggcacc  ccgggatgg  1500
aagtggctc  atgtccact  tcactgctc  ggagcccct  ctgcaccgc  gcagtgagc  1560
caggcacag  ggcattagg  gattccagc  ggaggctga  ccttcgaag  cagtgactc  1620
ggagggcct  agtgacagc  gcggtcctg  ccatttgag  tttaaacaa  tacattaca  1680
agcgcagca  ccaatgacg  ccctgcatg  agccctccc  cccgccctt  gtgtctgtc  1740
ctgctgtac  gaggtgttt  ttac  1764



<210> 7717
<211> 527
<212> PRT
<213> Rattus norvegicus
<308> AAB30670
<400> 7717

Met Ala Thr Thr Ala Thr Cys Thr Arg Phe Thr Asp Asp Tyr Gln Leu 
  1               5                  10                  15
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
             20                  25                  30
Lys Lys Thr Ser Thr Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
         35                  40                  45
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
     50                  55                  60
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
 65                  70                  75                  80
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                 85                  90                  95
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
             100                105                110
Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
         115                120                125
Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
     130                135                140
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
 145                150                155                160
Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                 165                170                175
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
             180                185                190
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
         195                200                205
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
     210                215                220
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
 225                230                235                240
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                 245                250                255
Pro Ala Lys Arg Ile Thr Ala Asp Gln Ala Leu Lys His Pro Trp Val 
             260                265                270
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
         275                280                285
Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
     290                295                300
Leu Thr Thr Met Leu Val Ser Arg Asn Phe Ser Val Gly Arg Gln Ser 
 305                310                315                320
Ser Ala Pro Ala Ser Pro Ala Ala Ser Ala Ala Gly Leu Ala Gly Gln 
                 325                330                335
Ala Ala Lys Ser Leu Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Lys 
             340                345                350
Arg Lys Ser Ser Ser Ser Val His Leu Met Glu Pro Gln Thr Thr Val 
         355                360                365
Val His Asn Ala Thr Asp Gly Ile Lys Gly Ser Thr Glu Ser Cys Asn 
     370                375                380
Thr Thr Thr Glu Asp Glu Asp Leu Lys Val Arg Lys Gln Glu Ile Ile 
 385                390                395                400
Lys Ile Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu 
                 405                410                415
Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu 
             420                425                430
Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe 
         435                440                445
Glu Asn Leu Leu Ser Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu 
     450                455                460
Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr 
 465                470                475                480
Ile Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser 
                 485                490                495
Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu 
             500                505                510
Asn Val His Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln 
         515                520                525



<210> 7718
<211> 444
<212> DNA
<213> Rattus norvegicus
<308> S72407
<400> 7718

aaagtatct  tgtcttcag  ggtgactgt  ttcgaacat  caagccaga  atcaagaaa  60
gaagctaca  taatatcgt  gtccatgtc  agaccgctg  tgctgacaa  ctccttttc  120
accttggga  tgcaaaatt  attgacttt  tggctatag  aatgcgtaa  gggaaagtc  180
gcttcctct  ggatgttgg  tctggagtt  gccgagtag  gtatccgga  ttgaccatc  240
acgactcat  ttggtaccg  attgaagca  caagaaccg  gagaaatgg  cttatttct  300
tgagagctt  ggatgggcc  aaagccagt  tggtgccca  cacccacca  tcagattct  360
ctcctgggt  cactatcct  gatgtggat  caaatgcaa  gctgtttgt  ggcggcctg  420
ctggaaaat  aaagaaggc  gacg  444



<210> 7719
<211> 3106
<212> PRT
<213> Rattus norvegicus
<308> AAC52165
<400> 7719

Met Pro Ala Ala Thr Ala Gly Ile Leu Leu Leu Leu Leu Leu Gly Thr 
  1               5                  10                  15
Leu Glu Gly Ser Gln Thr Gln Arg Arg Gln Ser Gln Ala His Gln Gln 
             20                  25                  30
Arg Gly Leu Phe Pro Ala Val Leu Asn Leu Ala Ser Asn Ala Leu Ile 
         35                  40                  45
Thr Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu Met Tyr Cys Lys 
     50                  55                  60
Leu Val Glu His Val Pro Gly Gln Pro Val Arg Asn Pro Gln Cys Arg 
 65                  70                  75                  80
Ile Cys Asn Gln Asn Ser Ser Asn Pro Tyr Gln Arg His Pro Ile Thr 
                 85                  90                  95
Asn Ala Ile Asp Gly Lys Asn Thr Trp Trp Gln Ser Pro Ser Ile Lys 
             100                105                110
Asn Gly Val Glu Tyr His Tyr Val Thr Ile Thr Leu Asp Leu Gln Gln 
         115                120                125
Val Phe Gln Ile Ala Tyr Val Ile Val Lys Ala Ala Asn Ser Pro Arg 
     130                135                140
Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Asp Val Glu Tyr Lys 
 145                150                155                160
Pro Trp Gln Tyr His Ala Val Thr Asp Thr Glu Cys Leu Thr Leu Tyr 
                 165                170                175
Asn Ile Tyr Pro Arg Thr Gly Pro Pro Ser Tyr Ala Lys Asp Asp Glu 
             180                185                190
Val Ile Cys Thr Ser Phe Tyr Ser Lys Ile His Pro Leu Glu Asn Gly 
         195                200                205
Glu Ile His Ile Ser Leu Ile Asn Gly Arg Pro Ser Ala Asp Asp Pro 
     210                215                220
Ser Pro Glu Leu Leu Glu Phe Thr Ser Ala Arg Tyr Ile Arg Leu Arg 
 225                230                235                240
Phe Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met Met Phe Ala His 
                 245                250                255
Lys Asp Pro Arg Glu Ile Asp Pro Ile Val Thr Arg Arg Tyr Tyr Tyr 
             260                265                270
Ser Val Lys Asp Ile Ser Val Gly Gly Met Cys Ile Cys Tyr Gly His 
         275                280                285
Ala Arg Ala Cys Pro Leu Asp Pro Ala Thr Asn Lys Ser Arg Cys Glu 
     290                295                300
Cys Glu His Asn Thr Cys Gly Glu Ser Cys Asp Arg Cys Cys Pro Gly 
 305                310                315                320
Phe His Gln Lys Pro Trp Arg Ala Gly Thr Phe Leu Thr Lys Ser Glu 
                 325                330                335
Cys Glu Ala Cys Asn Cys His Gly Lys Ala Glu Glu Cys Tyr Tyr Asp 
             340                345                350
Glu Thr Val Ala Ser Arg Asn Leu Ser Leu Asn Ile His Gly Lys Tyr 
         355                360                365
Ile Gly Gly Gly Val Cys Ile Asn Cys Thr His Asn Thr Ala Gly Ile 
     370                375                380
Asn Cys Glu Thr Cys Val Asp Gly Phe Phe Arg Pro Lys Gly Val Ser 
 385                390                395                400
Pro Asn Tyr Pro Arg Pro Cys Gln Pro Cys His Cys Asp Pro Thr Gly 
                 405                410                415
Ser Leu Ser Glu Val Cys Val Lys Asp Glu Lys Tyr Ala Gln Arg Gly 
             420                425                430
Leu Lys Pro Gly Ser Cys His Cys Lys Thr Gly Phe Gly Gly Val Asn 
         435                440                445
Cys Asp Arg Cys Val Arg Gly Tyr His Gly Tyr Pro Asp Cys Gln Pro 
     450                455                460
Cys Asn Cys Ser Gly Leu Gly Ser Thr Asn Glu Asp Pro Cys Val Gly 
 465                470                475                480
Pro Cys Ser Cys Lys Glu Asn Val Glu Gly Glu Asp Cys Ser Arg Cys 
                 485                490                495
Lys Ser Gly Phe Phe Asn Leu Gln Glu Asp Asn Gln Lys Gly Cys Glu 
             500                505                510
Glu Cys Phe Cys Ser Gly Val Ser Asn Arg Cys Gln Ser Ser Tyr Trp 
         515                520                525
Thr Tyr Gly Asn Ile Gln Asp Met Arg Gly Trp Tyr Leu Thr Asp Leu 
     530                535                540
Ser Gly Arg Ile Arg Met Ala Pro Gln Leu Asp Asn Pro Asp Ser Pro 
 545                550                555                560
Gln Gln Ile Ser Ile Ser Asn Ser Glu Ala Arg Lys Ser Leu Leu Asp 
                 565                570                575
Gly Tyr Tyr Trp Ser Ala Pro Pro Pro Tyr Leu Gly Asn Arg Leu Pro 
             580                585                590
Ala Val Gly Gly Gln Leu Ser Phe Thr Ile Ser Tyr Asp Leu Glu Glu 
         595                600                605
Glu Glu Asp Asp Thr Glu Lys Leu Leu Gln Leu Met Ile Ile Phe Glu 
     610                615                620
Gly Asn Asp Leu Arg Ile Ser Thr Ala Tyr Lys Glu Val Tyr Leu Glu 
 625                630                635                640
Pro Ser Glu Glu His Val Glu Glu Val Ser Leu Lys Glu Glu Ala Phe 
                 645                650                655
Thr Ile His Gly Thr Asn Leu Pro Val Thr Arg Lys Asp Phe Met Ile 
             660                665                670
Val Leu Thr Asn Leu Gly Glu Ile Leu Ile Gln Ile Thr Tyr Asn Leu 
         675                680                685
Gly Met Asp Ala Ile Phe Arg Leu Ser Ser Val Asn Leu Glu Ser Pro 
     690                695                700
Val Pro Tyr Pro Thr Asp Arg Arg Ile Ala Thr Asp Val Glu Val Cys 
 705                710                715                720
Gln Cys Pro Pro Gly Tyr Ser Gly Ser Ser Cys Glu Thr Cys Trp Pro 
                 725                730                735
Arg His Arg Arg Val Asn Gly Thr Ile Phe Gly Gly Ile Cys Glu Pro 
             740                745                750
Cys Gln Cys Phe Ala His Ala Glu Ala Cys Asp Asp Ile Thr Gly Glu 
         755                760                765
Cys Leu Asn Cys Lys Asp His Thr Gly Gly Pro Tyr Cys Asn Glu Cys 
     770                775                780
Leu Pro Gly Phe Tyr Gly Asp Pro Thr Arg Gly Ser Pro Glu Asp Cys 
 785                790                795                800
Gln Pro Cys Ala Cys Pro Leu Asn Ile Pro Ser Asn Asn Phe Ser Pro 
                 805                810                815
Thr Cys His Leu Asp Arg Ser Leu Gly Leu Ile Cys Asp Glu Cys Pro 
             820                825                830
Ile Gly Tyr Thr Gly Pro Arg Cys Glu Arg Cys Ala Glu Gly Tyr Phe 
         835                840                845
Gly Gln Pro Ser Val Pro Gly Gly Ser Cys Gln Pro Cys Gln Cys Asn 
     850                855                860
Asp Asn Leu Asp Tyr Ser Ile Pro Gly Ser Cys Asp Ser Leu Ser Gly 
 865                870                875                880
Ser Cys Leu Ile Cys Lys Pro Gly Thr Thr Gly Arg Tyr Cys Glu Leu 
                 885                890                895
Cys Ala Asp Gly Tyr Phe Gly Asp Ala Val Asn Thr Lys Asn Cys Gln 
             900                905                910
Pro Cys Arg Cys Asp Ile Asn Gly Ser Phe Ser Glu Asp Cys His Thr 
         915                920                925
Arg Thr Gly Gln Cys Glu Cys Arg Pro Asn Val Gln Gly Arg His Cys 
     930                935                940
Asp Glu Cys Lys Pro Glu Thr Phe Gly Leu Gln Leu Gly Arg Gly Cys 
 945                950                955                960
Leu Pro Cys Asn Cys Asn Ser Phe Gly Ser Lys Ser Phe Asp Cys Glu 
                 965                970                975
Ala Ser Gly Gln Cys Trp Cys Gln Pro Gly Val Ala Gly Lys Lys Cys 
             980                985                990
Asp Arg Cys Ala His Gly Tyr Phe Asn Phe Gln Glu Gly Gly Cys Ile 
         995                1000                1005
Ala Cys Asp Cys Ser His Leu Gly Asn Asn Cys Asp Pro Lys Thr Gly 
     1010                1015                1020
Gln Cys Ile Cys Pro Pro Asn Thr Thr Gly Glu Lys Cys Ser Glu Cys 
 1025                1030                1035                1040
Leu Pro Asn Thr Trp Gly His Ser Ile Val Thr Gly Cys Lys Val Cys 
                 1045                1050                1055
Asn Cys Ser Thr Val Gly Ser Leu Ala Ser Gln Cys Asn Val Asn Thr 
             1060                1065                1070
Gly Gln Cys Ser Cys His Pro Lys Phe Ser Gly Met Lys Cys Ser Glu 
         1075                1080                1085
Cys Ser Arg Gly His Trp Asn Tyr Pro Leu Cys Thr Leu Cys Asp Cys 
     1090                1095                1100
Phe Leu Pro Gly Thr Asp Ala Thr Thr Cys Asp Leu Glu Thr Arg Lys 
 1105                1110                1115                1120
Cys Ser Cys Ser Asp Gln Thr Gly Gln Cys Ser Cys Lys Val Asn Val 
                 1125                1130                1135
Glu Gly Val His Cys Asp Arg Cys Arg Pro Gly Lys Phe Gly Leu Asp 
             1140                1145                1150
Ala Lys Asn Pro Leu Gly Cys Ser Ser Cys Tyr Cys Phe Gly Val Thr 
         1155                1160                1165
Ser Gln Cys Ser Glu Ala Lys Gly Leu Ile Arg Thr Trp Val Thr Leu 
     1170                1175                1180
Ser Asp Glu Gln Thr Ile Leu Pro Leu Val Asp Glu Ala Leu Gln His 
 1185                1190                1195                1200
Thr Thr Thr Lys Gly Ile Ala Phe Gln Lys Pro Glu Ile Val Ala Lys 
                 1205                1210                1215
Met Asp Glu Val Arg Gln Glu Leu His Leu Glu Pro Phe Tyr Trp Lys 
             1220                1225                1230
Leu Pro Gln Gln Phe Glu Gly Lys Lys Leu Met Ala Tyr Gly Gly Lys 
         1235                1240                1245
Leu Lys Tyr Ala Ile Tyr Phe Glu Ala Arg Asp Glu Thr Gly Phe Ala 
     1250                1255                1260
Thr Tyr Lys Pro Gln Val Ile Ile Arg Gly Gly Thr Pro Thr His Ala 
 1265                1270                1275                1280
Arg Ile Ile Thr Arg His Met Ala Ala Pro Leu Ile Gly Gln Leu Thr 
                 1285                1290                1295
Arg His Glu Ile Glu Met Thr Glu Lys Glu Trp Lys Tyr Tyr Gly Asp 
             1300                1305                1310
Asp Pro Arg Ile Ser Arg Thr Val Thr Arg Glu Asp Phe Leu Asp Ile 
         1315                1320                1325
Leu Tyr Asp Ile His Tyr Ile Leu Ile Lys Ala Thr Tyr Gly Asn Val 
     1330                1335                1340
Val Arg Gln Ser Arg Ile Ser Glu Ile Ser Met Glu Val Ala Glu Pro 
 1345                1350                1355                1360
Gly His Val Leu Ala Gly Ser Pro Pro Ala His Leu Ile Glu Arg Cys 
                 1365                1370                1375
Asp Cys Pro Pro Gly Tyr Ser Gly Leu Ser Cys Glu Thr Cys Ala Pro 
             1380                1385                1390
Gly Phe Tyr Arg Leu Arg Ser Glu Pro Gly Gly Arg Thr Pro Gly Pro 
         1395                1400                1405
Thr Leu Gly Thr Cys Val Pro Cys Gln Cys Asn Gly His Ser Ser Gln 
     1410                1415                1420
Cys Asp Pro Glu Thr Ser Val Cys Gln Asn Cys Gln His His Thr Ala 
 1425                1430                1435                1440
Gly Asp Phe Cys Glu Arg Cys Ala Leu Gly Tyr Tyr Gly Ile Val Arg 
                 1445                1450                1455
Gly Leu Pro Asn Asp Cys Gln Pro Cys Ala Cys Pro Leu Ile Ser Pro 
             1460                1465                1470
Ser Asn Asn Phe Ser Pro Ser Cys Val Leu Glu Gly Leu Glu Asp Tyr 
         1475                1480                1485
Arg Cys Thr Ala Cys Pro Arg Gly Tyr Glu Gly Gln Tyr Cys Glu Arg 
     1490                1495                1500
Cys Ala Pro Gly Tyr Thr Gly Ser Pro Ser Ser Pro Gly Gly Ser Cys 
 1505                1510                1515                1520
Gln Glu Cys Glu Cys Asp Pro Tyr Gly Ser Leu Pro Val Pro Cys Asp 
                 1525                1530                1535
Arg Val Thr Gly Leu Cys Thr Cys Arg Pro Gly Ala Thr Gly Arg Lys 
             1540                1545                1550
Cys Asp Gly Cys Glu His Trp His Ala Arg Glu Gly Ala Glu Cys Val 
         1555                1560                1565
Phe Cys Gly Asp Glu Cys Thr Gly Leu Leu Leu Gly Asp Leu Ala Arg 
     1570                1575                1580
Leu Glu Gln Met Thr Met Asn Ile Asn Leu Thr Gly Pro Leu Pro Ala 
 1585                1590                1595                1600
Pro Tyr Lys Ile Leu Tyr Gly Leu Glu Asn Thr Thr Gln Glu Leu Lys 
                 1605                1610                1615
His Leu Leu Ser Pro Gln Arg Ala Pro Glu Arg Leu Ile Gln Leu Ala 
             1620                1625                1630
Glu Gly Asn Val Asn Thr Leu Val Met Glu Thr Asn Glu Leu Leu Thr 
         1635                1640                1645
Arg Ala Thr Lys Val Thr Ala Asp Gly Glu Gln Thr Gly Gln Asp Ala 
     1650                1655                1660
Glu Arg Thr Asn Ser Arg Ala Glu Ser Leu Glu Glu Phe Ile Lys Gly 
 1665                1670                1675                1680
Leu Val Gln Asp Ala Glu Ala Ile Asn Glu Lys Ala Val Lys Leu Asn 
                 1685                1690                1695
Glu Thr Leu Gly Asn Gln Asp Lys Thr Ala Glu Arg Asn Leu Glu Glu 
             1700                1705                1710
Leu Gln Lys Glu Ile Asp Arg Met Leu Lys Glu Leu Arg Ser Lys Asp 
         1715                1720                1725
Leu Gln Thr Gln Lys Glu Val Ala Glu Asp Glu Leu Val Ala Ala Glu 
     1730                1735                1740
Gly Leu Leu Lys Arg Val Asn Lys Leu Phe Gly Glu Pro Arg Ala Gln 
 1745                1750                1755                1760
Asn Glu Asp Met Glu Lys Asp Leu Gln Gln Lys Leu Ala Glu Tyr Lys 
                 1765                1770                1775
Asn Lys Leu Asp Asp Ala Trp Asp Leu Leu Arg Glu Ala Thr Asp Lys 
             1780                1785                1790
Thr Arg Asp Ala Asn Arg Leu Ser Ala Ala Asn Gln Lys Asn Met Thr 
         1795                1800                1805
Ile Leu Glu Thr Lys Lys Glu Ala Ile Glu Gly Ser Lys Arg Gln Ile 
     1810                1815                1820
Glu Asn Thr Leu Lys Glu Gly Asn Asp Ile Leu Asp Glu Ala Asn Gln 
 1825                1830                1835                1840
Leu Leu Gly Glu Ile Asn Ser Val Ile Asp Tyr Val Asp Asp Ile Lys 
                 1845                1850                1855
Thr Lys Leu Pro Pro Met Ser Glu Glu Leu Ser Asp Lys Ile Asp Asp 
             1860                1865                1870
Leu Ala Gln Glu Ile Lys Asp Arg Arg Leu Ala Glu Lys Val Phe Gln 
         1875                1880                1885
Ala Glu Ser His Ala Ala Gln Leu Asn Asp Ser Ser Ala Val Leu Asp 
     1890                1895                1900
Gly Ile Leu Asp Glu Ala Lys Asn Ile Ser Phe Asn Ala Thr Ala Ala 
 1905                1910                1915                1920
Phe Arg Ala Tyr Ser Asn Ile Lys Asp Tyr Ile Asp Glu Ala Glu Lys 
                 1925                1930                1935
Val Ala Arg Glu Ala Lys Glu Leu Ala Gln Gly Ala Thr Lys Leu Ala 
             1940                1945                1950
Thr Ser Pro Gln Gly Leu Leu Lys Glu Asp Ala Lys Gly Ser Leu Gln 
         1955                1960                1965
Lys Ser Phe Arg Ile Leu Asn Glu Ala Lys Lys Leu Ala Asn Asp Val 
     1970                1975                1980
Lys Gly Asn His Asn Asp Leu Asn Asp Leu Lys Thr Arg Leu Glu Thr 
 1985                1990                1995                2000
Ala Asp Leu Arg Asn Ser Gly Leu Leu Gly Ala Leu Asn Asp Thr Met 
                 2005                2010                2015
Asp Lys Leu Ser Ala Ile Thr Asn Asp Thr Ala Ala Lys Leu Gln Ala 
             2020                2025                2030
Val Lys Glu Lys Ala Arg Glu Ala Asn Asp Thr Ala Lys Ala Val Leu 
         2035                2040                2045
Ala Gln Val Lys Asp Leu His Gln Asn Leu Asp Gly Leu Lys Gln Asn 
     2050                2055                2060
Tyr Asn Lys Leu Ala Asp Ser Val Ala Lys Thr Asn Ala Val Val Lys 
 2065                2070                2075                2080
Asp Pro Ser Lys Asn Lys Ile Ile Ala Asp Ala Gly Thr Ser Val Arg 
                 2085                2090                2095
Asn Leu Glu Gln Glu Ala Asp Arg Leu Ile Asp Lys Leu Lys Pro Ile 
             2100                2105                2110
Lys Glu Leu Glu Asp Asn Leu Lys Lys Asn Ile Ser Glu Ile Lys Glu 
         2115                2120                2125
Leu Ile Asn Gln Ala Arg Lys Gln Ala Asn Ser Ile Lys Val Ser Val 
     2130                2135                2140
Ser Ser Gly Gly Asp Cys Val Arg Thr Tyr Arg Pro Glu Ile Lys Lys 
 2145                2150                2155                2160
Gly Ser Tyr Asn Asn Ile Val Val His Val Lys Thr Ala Val Ala Asp 
                 2165                2170                2175
Asn Leu Leu Phe Tyr Leu Gly Ser Ala Lys Phe Ile Asp Phe Leu Ala 
             2180                2185                2190
Ile Glu Met Arg Lys Gly Lys Val Ser Phe Leu Trp Ile Val Gly Ser 
         2195                2200                2205
Gly Val Gly Arg Val Gly Phe Pro Asp Leu Thr Ile Asp Asp Ser Tyr 
     2210                2215                2220
Trp Tyr Arg Ile Glu Ala Ser Arg Thr Gly Arg Asn Gly Ser Ile Ser 
 2225                2230                2235                2240
Val Arg Ala Leu Asp Gly Pro Lys Ala Ser Met Val Pro Ser Thr Tyr 
                 2245                2250                2255
His Ser Val Ser Pro Pro Gly Tyr Thr Ile Leu Asp Val Asp Ala Asn 
             2260                2265                2270
Ala Met Leu Phe Val Gly Gly Leu Thr Gly Lys Ile Lys Lys Ala Asp 
         2275                2280                2285
Ala Val Arg Val Ile Thr Phe Thr Gly Cys Met Gly Glu Thr Tyr Phe 
     2290                2295                2300
Asp Asn Lys Pro Ile Gly Leu Trp Asn Phe Arg Glu Lys Glu Gly Asp 
 2305                2310                2315                2320
Cys Lys Gly Cys Thr Val Ser Pro Gln Val Glu Asp Ser Glu Gly Thr 
                 2325                2330                2335
Ile Gln Phe Asp Gly Glu Gly Tyr Ala Leu Val Ser Arg Pro Ile Arg 
             2340                2345                2350
Trp Tyr Pro Asn Ile Ser Thr Val Met Phe Lys Phe Arg Thr Phe Ser 
         2355                2360                2365
Ser Ser Ala Leu Leu Met Tyr Leu Ala Thr Arg Asp Leu Lys Asp Phe 
     2370                2375                2380
Met Ser Val Glu Leu Ser Asp Gly His Val Lys Val Ser Tyr Asp Leu 
 2385                2390                2395                2400
Gly Ser Gly Met Thr Ser Val Val Ser Asn Gln Asn His Asn Asp Gly 
                 2405                2410                2415
Lys Trp Lys Ala Phe Thr Leu Ser Arg Ile Gln Lys Gln Ala Asn Ile 
             2420                2425                2430
Ser Ile Val Asp Ile Asp Ser Asn Gln Glu Glu Asn Val Ala Thr Ser 
         2435                2440                2445
Ser Ser Gly Asn Asn Phe Gly Leu Asp Leu Lys Ala Asp Asp Lys Ile 
     2450                2455                2460
Tyr Phe Gly Gly Leu Pro Thr Leu Arg Asn Leu Ser Met Lys Ala Arg 
 2465                2470                2475                2480
Pro Glu Val Asn Val Lys Lys Tyr Ser Gly Cys Leu Lys Asp Ile Glu 
                 2485                2490                2495
Ile Ser Arg Thr Pro Tyr Asn Ile Leu Ser Ser Pro Asp Tyr Val Gly 
             2500                2505                2510
Val Thr Lys Gly Cys Ser Leu Glu Asn Val Asn Thr Val Ser Phe Pro 
         2515                2520                2525
Lys Pro Gly Phe Val Glu Leu Ala Ala Val Ser Ile Asp Val Gly Thr 
     2530                2535                2540
Glu Ile Asn Leu Ser Phe Ser Thr Arg Asn Glu Ser Gly Ile Ile Leu 
 2545                2550                2555                2560
Leu Gly Ser Gly Gly Thr Leu Thr Pro Pro Arg Arg Lys Arg Arg Gln 
                 2565                2570                2575
Thr Thr Gln Ala Tyr Tyr Ala Ile Phe Leu Asn Lys Gly Arg Leu Glu 
             2580                2585                2590
Val His Leu Ser Ser Gly Thr Arg Thr Met Arg Lys Ile Val Ile Lys 
         2595                2600                2605
Pro Glu Pro Asn Leu Phe His Asp Gly Arg Glu His Ser Val His Val 
     2610                2615                2620
Glu Arg Thr Arg Gly Ile Phe Thr Val Gln Ile Asp Glu Asp Arg Arg 
 2625                2630                2635                2640
His Ile Gln Asn Leu Thr Glu Glu Gln Pro Ile Glu Val Lys Lys Leu 
                 2645                2650                2655
Phe Val Gly Gly Ala Pro Pro Glu Phe Gln Pro Ser Pro Leu Arg Asn 
             2660                2665                2670
Ile Pro Ala Phe Gln Gly Cys Val Trp Asn Leu Val Ile Asn Ser Ile 
         2675                2680                2685
Pro Met Asp Phe Ala Gln Pro Ile Ala Phe Lys Asn Ala Asp Ile Gly 
     2690                2695                2700
Arg Cys Thr Tyr Gln Lys Pro Arg Glu Asp Glu Ser Glu Ala Val Pro 
 2705                2710                2715                2720
Ala Glu Val Ile Val Gln Pro Gln Ser Val Pro Thr Pro Ala Phe Pro 
                 2725                2730                2735
Phe Pro Val Pro Thr Met Val His Gly Pro Cys Val Ala Glu Ser Glu 
             2740                2745                2750
Pro Ala Leu Leu Thr Gly Ser Lys Gln Phe Gly Leu Ser Arg Asn Ser 
         2755                2760                2765
His Ile Ala Ile Val Phe Asp Asp Thr Lys Val Lys Asn Arg Leu Thr 
     2770                2775                2780
Ile Glu Leu Glu Val Arg Thr Glu Ala Glu Ser Gly Leu Leu Phe Tyr 
 2785                2790                2795                2800
Met Gly Arg Ile Asn His Ala Asp Phe Gly Thr Val Gln Leu Arg Asn 
                 2805                2810                2815
Gly Phe Pro Phe Phe Ser Tyr Asp Leu Gly Ser Gly Ser Thr Arg Thr 
             2820                2825                2830
Met Ile Pro Thr Lys Ile Asn Asp Gly Gln Trp His Lys Ile Lys Ile 
         2835                2840                2845
Val Arg Val Lys Gln Glu Gly Ile Leu Tyr Val Asp Asp Ala Ser Ser 
     2850                2855                2860
Gln Thr Ile Ser Pro Lys Lys Ala Asp Ile Leu Asp Val Gly Gly Ile 
 2865                2870                2875                2880
Leu Tyr Val Gly Gly Leu Pro Ile Asn Tyr Thr Thr Arg Arg Ile Gly 
                 2885                2890                2895
Pro Val Thr Tyr Ser Leu Asp Gly Cys Val Arg Asn Leu His Met Glu 
             2900                2905                2910
Gln Ala Pro Val Asp Leu Asp Gln Pro Thr Ser Ser Phe His Val Gly 
         2915                2920                2925
Thr Cys Phe Ala Asn Ala Glu Ser Gly Thr Tyr Phe Asp Gly Thr Gly 
     2930                2935                2940
Phe Gly Lys Ala Val Gly Gly Phe Ile Val Gly Leu Asp Leu Leu Val 
 2945                2950                2955                2960
Glu Phe Glu Phe Arg Thr Thr Arg Pro Thr Gly Val Leu Leu Gly Ile 
                 2965                2970                2975
Ser Ser Gln Lys Met Asp Gly Met Gly Ile Glu Met Ile Asp Glu Lys 
             2980                2985                2990
Leu Met Phe His Val Asp Asn Gly Ala Gly Arg Phe Thr Ala Ile Tyr 
         2995                3000                3005
Asp Ala Glu Ile Pro Gly His Met Cys Asn Gly Gln Trp Tyr Lys Val 
     3010                3015                3020
Thr Ala Lys Lys Ile Lys Asn Arg Leu Glu Leu Val Val Asp Gly Asn 
 3025                3030                3035                3040
Gln Val Asp Ala Gln Ser Pro Asn Ser Ala Ser Thr Ser Ala Asp Thr 
                 3045                3050                3055
Asn Asp Pro Val Phe Val Gly Gly Phe Pro Gly Gly Leu Asn Gln Phe 
             3060                3065                3070
Gly Leu Thr Thr Asn Ile Arg Phe Arg Gly Cys Ile Arg Ser Leu Lys 
         3075                3080                3085
Leu Thr Lys Gly Thr Ala Asn Arg Trp Arg Leu Ile Leu Pro Arg Pro 
     3090                3095                3100
Trp Asn 
 3105



<210> 7720
<211> 9535
<212> DNA
<213> Homo sapiens
<308> XM_011387
<400> 7720

cagcgactc  tctggctcc  gagaagtgg  tccggtcgc  gccactacg  tgccgggag  60
cgccggggt  ctcctcctt  tgctgctct  cggaggcct  gggggcgta  aggcgcagc  120
gccgcagca  cagcggcag  cacaggcac  tcagcaaag  ggtttattc  ctgctgtcc  180
gaatcttgc  tctaatgct  ttatcacga  caatgcaac  tgtggagaa  aaggacctg  240
aatgtactg  aaattggta  aacatgtcc  tgggcagcc  gtgaggaac  cgcagtgtc  300
aatctgcaa  caaaacagc  gcaatccaa  ccagagaca  ccgattaca  atgctattg  360
tggaaagaa  acttggtgg  agagtccca  tattaagaa  ggaatcgaa  accattatg  420
gacaattac  ctggattta  agcaggtgt  ccagatcgc  tatgtgatt  tgaaggcag  480
taactcccc  cggcctgga  actggattt  ggaacgctc  cttgatgat  ttgaataca  540
gccctggca  tatcatgct  tgacagaca  ggagtgcct  acgctttac  atatttatc  600
ccgcactgg  ccaccgtca  atgccaaag  tgatgaggt  atctgcact  cattttact  660
caagataca  cccttagaa  atggagaga  tcacatctc  ttaatcaat  ggagaccaa  720
tgccgatga  ccttctcca  aactgctag  atttacctc  gctcgctat  ttcgcctga  780
atttcagag  atccgcaca  tgaatgctg  cttgatgat  tttgctcac  aagacccaa  840
agaaattga  cccattgtc  ccagaagat  ttactactc  gtcaaggat  tttcagttg  900
agggatgtg  atctgctat  gtcatgcca  ggcttgtcc  cttgatcca  cgacaaata  960
atctcgctg  gagtgtgag  ataacacat  tggcgatag  tgtgatcag  gctgtccag  1020
attccatca  aaaccctgg  gagctggaa  ttttctaac  aaaactgaa  gtgaagcat  1080
caattgtca  ggaaaagct  aagaatgct  ttatgatga  aatgttgcc  gaagaaatc  1140
gagtttgaa  atacgtgga  agtacattg  agggggtgt  tgcattaat  gtacccaaa  1200
cactgctgg  ataaactgc  agacatgta  tgatggctt  ttcagaccc  aaggggtat  1260
tccaaatta  ccaaggcca  gccagccat  tcattgcga  ccaattggt  ccttaaatg  1320
agtctgtgt  aaggatgag  aacatgctc  acgaggttt  gcacctgga  cctgtcatt  1380
caaaactgg  tttggaggt  tgagctgtg  tcggtgtgc  aggggctac  ctggctacc  1440
ggactgcaa  gcctgtaac  gcagtgggt  agggagcaa  aatgaggat  cttgttttg  1500
cccctgtat  tgcaaggaa  atgttgaag  aggagactg  agtcgttgc  aatccggct  1560
cttcaattt  caagaggat  attggaaag  ctgcgatga  tgtttctgt  caggggttt  1620
aaacagatg  cagagttcc  actggacct  tggcaaaat  caagatatg  gtggctggt  1680
tctgactga  cttcctggc  gcattcgag  ggctcccca  caggacgac  tggactcac  1740
tcagcagat  agcatcagt  acgcggagg  ccggcaagc  ctgccgcac  gctactact  1800
gagcgcgcc  gctccctat  tgggaaaca  actcccagc  gtaggagga  agttgacat  1860
taccatatc  tatgacctt  aagaagagg  agaagatac  gaacgtgtt  tccagctta  1920
gattatctt  gagggtaat  acttgagca  cagcacagc  caagatgag  tgtacctgc  1980
cccatctga  gaacatact  atgtattgt  acttaaaga  gaatcattt  ccatacatg  2040
cacacattt  ccagtccgt  gaaaggaat  tatgacagt  cttgcgaat  tgaagagag  2100
cctcctaca  atcacatac  gctttggga  ggatgccat  ttcaggttg  gctctgtta  2160
ccttgaatc  gctgtctcc  atcctactg  tggaagcat  gcagcagct  tagaagtgt  2220
tcagtgccc  ccagggtat  ctggctcct  ttgtgaatc  tgttggcct  ggcacaggc  2280
agttaacgg  actattttt  gtggcatct  tgagccatg  cagtgcttt  gtcatgcgg  2340
gtcctgtga  gacgtcact  gagaatgcc  gaactgtaa  gatcacaca  gtggcccat  2400
ttgtgataa  tgtcttcct  gtttctatg  cgagcctac  aaaggaacc  ctgaagact  2460
tcaaccctg  gcctgtcca  tcaatatcc  atccaataa  tttagccca  cgtgccatt  2520
agaccggag  cttggattg  tctgtgatg  atgccctgt  gggtacaca  gaccacgct  2580
tgagaggtg  gcagaaggc  attttggac  accctctgt  cctggagga  catgtcagc  2640
atgccaatg  aatgacaac  ttgacttct  catccctgg  agctgtgac  gcttgtctg  2700
ctcctgtct  atatgtaaa  caggtacaa  aggccggta  tgtgagctc  gtgctgatg  2760
atattttgg  gatgcagtt  atgcgaaga  ctgtcagcc  tgtcgctgt  atgccggtg  2820
ctctttctc  gaggtttgc  acagtcaaa  tggacagtg  gagtgcaga  ccaacgttc  2880
gggtcagag  tgtgacaaa  gcaaggctg  gacctttgg  ctacaatca  caaggggct  2940
tgttccctg  aactgcaat  cttttgggt  taagtcatt  gactgtgaa  agagtggac  3000
atgttggtg  caacctgga  tcacaggga  gaaatgtga  cgctgtgcc  acggctatt  3060
caacttcca  gaaggaggc  gcacagctt  tgaatgttc  catctgggt  ataattgtg  3120
cccaaagac  gggcgatgc  tttgccctc  caataccat  ggagagaaa  gttctaaat  3180
tgcacccaa  acctggggc  acagcatta  cactggttg  aaggcttgt  actgcagca  3240
agtgggatc  ttggatttc  aatgcaatg  aaatacagg  caatgcaac  gtcatccaa  3300
attctctgg  gcaaaatgt  cagagtgca  tcgaggtca  tggaactac  ctcgctgca  3360
tctctgtga  tgcttcctc  ctgggacag  tgccacaac  tgtgattca  agactaaaa  3420
atgctcctg  agtgatcaa  ctgggcagt  cacttgtaa  gtgaatgtg  aaggcatcc  3480
ctgtgacag  tgccggcct  gcaaattcg  actcgatgc  aagaatcca  ttggctgca  3540
cagctgcta  tgcttcggc  ctactaccc  gtgctctga  gcaaaagga  tgatccgga  3600
gtgggtgac  ctgaaggct  agcagacca  tctacccct  gtagatgag  ctctgcagc  3660
cacgaccac  aagggcatt  tttttcaac  tccagagat  gttgcccac  tggacctga  3720
gagagaaga  ctccatttg  aaccttttt  ttggaaact  ccagaacaa  ttgaaggaa  3780
gaagttgat  gcctatggg  gcaaactca  gtatgcaat  tatttcgag  ctcgggaag  3840
aacaggttt  tctacatat  atcctcaag  gatcattcg  ggtgggaca  ctactcatg  3900
tagaattat  gtcaggcat  tggctgctc  tctgattgg  caattgaca  ggcatgaaa  3960
tgaaatgac  gagaaagaa  ggaaatatt  tggggatga  cctcgagtc  atagaactg  4020
gacccgaga  gacttcttg  atatactat  tgatattca  tacattctt  tcaaagcta  4080
ttatggaaa  ttcatgcga  aaagcagga  ttctgaaat  tcaatggag  tagctgaac  4140
aggacgtgg  acaacaatg  ctcctccag  tgacttgat  gaaaaatgt  attgtcccc  4200
gggctattc  ggcctgtcc  gtgaggcat  cttgccggg  ttttatcga  tgcgttctc  4260
accaggtgg  cgcacccct  gaccaaccc  gggcacctg  gttccatgt  aatgtaatg  4320
acacagcag  ctgtgtgac  ctgaaacat  gatatgcca  aattgtcaa  atcacactg  4380
tggtgactt  tgtgaacga  gtgctcttg  atactatgg  attgtcaag  gattgccaa  4440
tgactgtca  caatgtgcc  gccctctga  ttcttccag  aacaatttc  gcccctctt  4500
tgtcgcaga  ggacttgac  actaccgct  cacggcttg  ccacgggga  atgaaggcc  4560
gtactgtga  aggtgtgcc  ctggctata  tggcagtcc  ggcaaccct  gaggctcct  4620
ccaagaatg  gagtgtgat  cctatggct  actgcctgt  ccctgtgac  ctgtcacag  4680
attctgcac  tgccgacct  gagccacgg  aaggaagtg  gacggctgc  agcactggc  4740
tgcacgcga  ggctgggag  gtgtttttt  tggagatga  tgcactggc  ttcttctcg  4800
tgacttggc  cgcctggag  agatggtca  gagcatcaa  ctcactggt  cgctgcctg  4860
gccatataa  atgctgtat  gtcttgaaa  tatgactca  gagctaaag  acttgctgt  4920
acctcagcg  gccccagag  ggcttattc  gctggcaga  ggcaatctg  atacactcg  4980
gaccgaaat  aacgagctg  tgaccaggg  taccaaagt  acagcagat  gcgagcaga  5040
cggacagga  gctgagagg  ccaacacaa  agcaaagtc  ctgggagaa  tcattaagg  5100
gcttgcccg  gatgcagaa  ctgtaaatg  aaaagctat  aaactaaat  aaactctag  5160
aactcgaga  gaggccttt  agagaaatt  ggaagggct  cagaaagag  ttgaccaga  5220
gattaaaga  ctgaggagg  aaaatctag  gacacaaaa  gaaattgct  aagatgagt  5280
ggtagctgc  gaagccctt  tgaaaaaag  gaagaagct  tttggagag  cccgggggg  5340
aaatgaaga  atggagaag  atctccggg  aaaactggc  gactacaaa  acaaagttg  5400
tgatgcttg  gaccttttg  gagaagcca  agataaaat  agagaagct  atcgcctat  5460
tgcagtaaa  cagaaaaac  tgactgcat  ggagaaaaa  aaggaggct  ttgaaagcg  5520
caaacgaca  attgagaac  ctttaaaag  gggcaatga  atactcgat  aagccaacc  5580
tcttgcaga  gaaatcaac  ccatcatag  ctatgttga  gacatccaa  ctaaattgc  5640
acctatgtc  gaggagctt  atgataaaa  agatgacct  tcccaagaa  taaaggaca  5700
gaagcttgc  gagaaggtg  cccaggctg  gagccacgc  gctcagttg  atgactcat  5760
tgctgtcct  gatggaatc  ttgatgagg  taaaaacat  tccttcaat  ccactgcag  5820
cttcaaagc  tacagcaat  ttaaggact  tattgatga  gctgagaaa  ttgccaaag  5880
agccaaaga  cttgcacat  aagctacaa  actggcaac  ggtcctcgg  gtttattaa  5940
ggaagatgc  aaaggctgt  ttcagaaaa  cttcaggat  cttaacgaa  ccaagaagt  6000
agcaaatga  gtaaaagaa  atgaagacc  tctaaatgg  ttaaaaacc  ggatagaaa  6060
tgctgatgc  agaaatggg  atctcttga  aactttgaa  gacactttg  gaaagttat  6120
agctattcc  aatgataca  ctgctaaac  gcaagctgt  aaggacaaa  ccagacaag  6180
caacgacac  gctaaagat  tactggcac  gattacaga  ctccaccag  acctcgatg  6240
cctgaagaa  aattacaat  aactagcag  cagcgtcgc  aaaacgaat  ctgtggtta  6300
agatccttc  aagaacagt  agattgccg  tgcagatgc  actgtcaaa  atttagaac  6360
ggaagctga  cggctaata  ataaactca  acccatcaa  gaacttgag  ataacctaa  6420
gaaaaacat  tctgagata  aggaattga  aaaccaagc  cggaaacaa  ccaattcta  6480
caaagtatc  gtgtcttca  gaggtgact  cattcgaac  tacaaacca  aaatcaaga  6540
aggaagtta  aataatatt  ttgtcaacg  aaagacagc  gttgctgat  acctcctct  6600
ttatcttgg  agtgccaaa  ttattgact  tctggctat  gaaatgcgt  aaggcaaag  6660
cagcttcct  tgggatgtt  gatctggag  tggacgtgt  gagtaccca  atttgacta  6720
tgatgactc  tattggtac  gtatcgtag  atcaagaac  gggagaaat  gaactattt  6780
tgtgagagc  ctggatgga  ccaaagcca  cattgtgcc  agcacacac  attcgacgt  6840
tcctccagg  tacacgatt  tagatgtgg  tgcaaatgc  atgctgttt  ttggtggcc  6900
gactgggaa  ttaaagaag  ctgatgctg  acgtgtgat  acattcact  gctgcatgg  6960
agaaacata  tttgacaac  aacctatag  tttgtggaa  ttccgagaa  aagaaggtg  7020
ctgcaaagg  tgcactgtc  gtcctcagg  ggaagatag  gaggggact  ttcaatttg  7080
tggagaagg  tatgcattg  tcagccgtc  cattcgctg  taccccaac  tctccactg  7140
catgttcaa  ttcagaaca  tttcttcga  tgctcttct  atgtatctt  ccacacgag  7200
cctgagaga  ttcatgagt  tggagctca  tgatgggca  ataaaagtc  gttacgatc  7260
gggctcagg  atggcttcc  ttgtcagca  tcaaaacca  aatgatggg  aatggaaat  7320
attcactct  tcaagaatt  aaaaacaag  caatatatc  attgtagat  tagatacta  7380
tcaggagga  aatatagca  cttcgtctt  tggaaacaa  tttggtctt  acttgaaag  7440
agatgacaa  atatatttt  gtggcctgc  aacgctgag  aacttgagt  tgaaagcaa  7500
gccagaagt  aatctgaag  aatattccg  ctgcctcaa  gatattgaa  tttcaagaa  7560
tccgtacaa  atactcagt  gtcccgatt  tgttggtgt  accaaagga  gttccctgg  7620
gaatgttta  acagttagc  ttcctaagc  tggttttgt  gagctctcc  ctgtgccaa  7680
tgatgtagg  acagaaatc  acctgtcat  cagcaccaa  aatgagtcc  gcatcattc  7740
tttgggaag  ggagggaca  cagcaccac  taggagaaa  cgaaggcag  ctggacagg  7800
ctattatgc  atactcctc  acaggggcc  tctggaagt  catctctcc  caggggcac  7860
aacaatgag  aaaattgtg  tcagaccag  gccgaatct  tttcatgat  gaagagaac  7920
ttccgttca  gtagagcga  ctagaggca  ctttacagt  caagtggat  aaaacagaa  7980
atacatgca  aacctgaca  ttgaacagc  tatcgaagt  aaaaagctt  tcgttgggg  8040
tgctccacc  gaatttcaa  cttccccac  cagaaatat  cctcctttt  aaggctgca  8100
atggaatct  gttattaac  ctgtcccca  ggactttgc  aggcctgtg  ccttcaaaa  8160
tgctgacat  ggtcgctgt  cccatcaga  actccgtga  gatgaagat  gagcagctc  8220
agctgaaat  gttatccag  ctgagccag  tcccacccc  gcctttcct  cgcccaccc  8280
agttctgac  catggtcct  gtgctgcag  atcagaacc  gctcttttg  tagggagca  8340
gcagttcgg  ctttcaaga  acagtcaca  tgcaattgc  tttgatgac  ccaaagtta  8400
aaaccgtct  acaattgag  tggaagtaa  aaccgaagc  gaatccggc  tgctttttt  8460
catggctcg  atcaatcat  ctgattttg  aacagttca  ctgagaaat  gattgccct  8520
cttcagcta  gacttgggg  gtggggaca  ccacaccat  atccccacc  aaatcaatg  8580
tggccagtg  cacaagatt  agataatga  aagtaagca  gaaggaatt  tttatgtag  8640
tggggcttc  aacagaacc  tcagtccca  aaaagccga  atcctggat  tcgtgggaa  8700
gctgtatgt  ggtgggtta  ccatcaact  cactacccg  agaattggt  cagtgacct  8760
tagcattga  ggctgcgtc  ggaatctcc  catggcaga  gcccctgcc  atctggaac  8820
acccacctc  agcttccat  ttgggacat  ttttgcaaa  gctcagagg  gaacatatt  8880
tgacggaac  ggttttgcc  aagcagttg  tggattcaa  gtgggattg  accttcttg  8940
agaatttga  ttccgcaca  ctacaacga  tggagttct  ctggggatc  gtagtcaaa  9000
aatggatgg  atgggtatt  aaatgattg  tgaaaagtt  atgtttcat  tggacaatg  9060
tgcgggcag  ttcactgct  tctatgatg  tggggttcc  gggcatttg  gtgatggac  9120
atggcataa  gtcactgcc  acaagatca  acaccgcat  gagctcaca  tcgatggga  9180
ccaggtgga  gcccaaagc  caaacccag  atctacatc  gctgacaca  atgaccctg  9240
gtttgttgg  ggcttccca  atgacctca  gcagtttgg  ctaacaacc  gtattccgt  9300
ccgaggttg  atcagatcc  tgaagctca  caaaggcac  ggcaagcca  tggaggtta  9360
ttttgccaa  gccctggaa  tgaggggcg  tcaacctgt  tcatgccca  ccaactaat  9420
aaaataagt  taaccccag  aagagtctg  caaaacaag  atatcaagt  aaacaaaca  9480
atatatttt  cctatatat  ttaattaaa  taatttgtg  atgtacata  aattc  9535



<210> 7721
<211> 3122
<212> PRT
<213> Homo sapiens
<308> XP_011387
<400> 7721

Met Pro Gly Ala Ala Gly Val Leu Leu Leu Leu Leu Leu Ser Gly Gly 
  1               5                  10                  15
Leu Gly Gly Val Gln Ala Gln Arg Pro Gln Gln Gln Arg Gln Ser Gln 
             20                  25                  30
Ala His Gln Gln Arg Gly Leu Phe Pro Ala Val Leu Asn Leu Ala Ser 
         35                  40                  45
Asn Ala Leu Ile Thr Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu 
     50                  55                  60
Met Tyr Cys Lys Leu Val Glu His Val Pro Gly Gln Pro Val Arg Asn 
 65                  70                  75                  80
Pro Gln Cys Arg Ile Cys Asn Gln Asn Ser Ser Asn Pro Asn Gln Arg 
                 85                  90                  95
His Pro Ile Thr Asn Ala Ile Asp Gly Lys Asn Thr Trp Trp Gln Ser 
             100                105                110
Pro Ser Ile Lys Asn Gly Ile Glu Tyr His Tyr Val Thr Ile Thr Leu 
         115                120                125
Asp Leu Gln Gln Val Phe Gln Ile Ala Tyr Val Ile Val Lys Ala Ala 
     130                135                140
Asn Ser Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Asp 
 145                150                155                160
Val Glu Tyr Lys Pro Trp Gln Tyr His Ala Val Thr Asp Thr Glu Cys 
                 165                170                175
Leu Thr Leu Tyr Asn Ile Tyr Pro Arg Thr Gly Pro Pro Ser Tyr Ala 
             180                185                190
Lys Asp Asp Glu Val Ile Cys Thr Ser Phe Tyr Ser Lys Ile His Pro 
         195                200                205
Leu Glu Asn Gly Glu Ile His Ile Ser Leu Ile Asn Gly Arg Pro Ser 
     210                215                220
Ala Asp Asp Pro Ser Pro Glu Leu Leu Glu Phe Thr Ser Ala Arg Tyr 
 225                230                235                240
Ile Arg Leu Arg Phe Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met 
                 245                250                255
Met Phe Ala His Lys Asp Pro Arg Glu Ile Asp Pro Ile Val Thr Arg 
             260                265                270
Arg Tyr Tyr Tyr Ser Val Lys Asp Ile Ser Val Gly Gly Met Cys Ile 
         275                280                285
Cys Tyr Gly His Ala Arg Ala Cys Pro Leu Asp Pro Ala Thr Asn Lys 
     290                295                300
Ser Arg Cys Glu Cys Glu His Asn Thr Cys Gly Asp Ser Cys Asp Gln 
 305                310                315                320
Cys Cys Pro Gly Phe His Gln Lys Pro Trp Arg Ala Gly Thr Phe Leu 
                 325                330                335
Thr Lys Thr Glu Cys Glu Ala Cys Asn Cys His Gly Lys Ala Glu Glu 
             340                345                350
Cys Tyr Tyr Asp Glu Asn Val Ala Arg Arg Asn Leu Ser Leu Asn Ile 
         355                360                365
Arg Gly Lys Tyr Ile Gly Gly Gly Val Cys Ile Asn Cys Thr Gln Asn 
     370                375                380
Thr Ala Gly Ile Asn Cys Glu Thr Cys Thr Asp Gly Phe Phe Arg Pro 
 385                390                395                400
Lys Gly Val Ser Pro Asn Tyr Pro Arg Pro Cys Gln Pro Cys His Cys 
                 405                410                415
Asp Pro Ile Gly Ser Leu Asn Glu Val Cys Val Lys Asp Glu Lys His 
             420                425                430
Ala Arg Arg Gly Leu Ala Pro Gly Ser Cys His Cys Lys Thr Gly Phe 
         435                440                445
Gly Gly Val Ser Cys Asp Arg Cys Ala Arg Gly Tyr Thr Gly Tyr Pro 
     450                455                460
Asp Cys Lys Ala Cys Asn Cys Ser Gly Leu Gly Ser Lys Asn Glu Asp 
 465                470                475                480
Pro Cys Phe Gly Pro Cys Ile Cys Lys Glu Asn Val Glu Gly Gly Asp 
                 485                490                495
Cys Ser Arg Cys Lys Ser Gly Phe Phe Asn Leu Gln Glu Asp Asn Trp 
             500                505                510
Lys Gly Cys Asp Glu Cys Phe Cys Ser Gly Val Ser Asn Arg Cys Gln 
         515                520                525
Ser Ser Tyr Trp Thr Tyr Gly Lys Ile Gln Asp Met Ser Gly Trp Tyr 
     530                535                540
Leu Thr Asp Leu Pro Gly Arg Ile Arg Val Ala Pro Gln Gln Asp Asp 
 545                550                555                560
Leu Asp Ser Pro Gln Gln Ile Ser Ile Ser Asn Ala Glu Ala Arg Gln 
                 565                570                575
Ala Leu Pro His Ser Tyr Tyr Trp Ser Ala Pro Ala Pro Tyr Leu Gly 
             580                585                590
Asn Lys Leu Pro Ala Val Gly Gly Gln Leu Thr Phe Thr Ile Ser Tyr 
         595                600                605
Asp Leu Glu Glu Glu Glu Glu Asp Thr Glu Arg Val Leu Gln Leu Met 
     610                615                620
Ile Ile Leu Glu Gly Asn Asp Leu Ser Ile Ser Thr Ala Gln Asp Glu 
 625                630                635                640
Val Tyr Leu His Pro Ser Glu Glu His Thr Asn Val Leu Leu Leu Lys 
                 645                650                655
Glu Glu Ser Phe Thr Ile His Gly Thr His Phe Pro Val Arg Arg Lys 
             660                665                670
Glu Phe Met Thr Val Leu Ala Asn Leu Lys Arg Val Leu Leu Gln Ile 
         675                680                685
Thr Tyr Ser Phe Gly Met Asp Ala Ile Phe Arg Leu Ser Ser Val Asn 
     690                695                700
Leu Glu Ser Ala Val Ser Tyr Pro Thr Asp Gly Ser Ile Ala Ala Ala 
 705                710                715                720
Val Glu Val Cys Gln Cys Pro Pro Gly Tyr Thr Gly Ser Ser Cys Glu 
                 725                730                735
Ser Cys Trp Pro Arg His Arg Arg Val Asn Gly Thr Ile Phe Gly Gly 
             740                745                750
Ile Cys Glu Pro Cys Gln Cys Phe Gly His Ala Glu Ser Cys Asp Asp 
         755                760                765
Val Thr Gly Glu Cys Leu Asn Cys Lys Asp His Thr Gly Gly Pro Tyr 
     770                775                780
Cys Asp Lys Cys Leu Pro Gly Phe Tyr Gly Glu Pro Thr Lys Gly Thr 
 785                790                795                800
Ser Glu Asp Cys Gln Pro Cys Ala Cys Pro Leu Asn Ile Pro Ser Asn 
                 805                810                815
Asn Phe Ser Pro Thr Cys His Leu Asp Arg Ser Leu Gly Leu Ile Cys 
             820                825                830
Asp Gly Cys Pro Val Gly Tyr Thr Gly Pro Arg Cys Glu Arg Cys Ala 
         835                840                845
Glu Gly Tyr Phe Gly Gln Pro Ser Val Pro Gly Gly Ser Cys Gln Pro 
     850                855                860
Cys Gln Cys Asn Asp Asn Leu Asp Phe Ser Ile Pro Gly Ser Cys Asp 
 865                870                875                880
Ser Leu Ser Gly Ser Cys Leu Ile Cys Lys Pro Gly Thr Thr Gly Arg 
                 885                890                895
Tyr Cys Glu Leu Cys Ala Asp Gly Tyr Phe Gly Asp Ala Val Asp Ala 
             900                905                910
Lys Asn Cys Gln Pro Cys Arg Cys Asn Ala Gly Gly Ser Phe Ser Glu 
         915                920                925
Val Cys His Ser Gln Thr Gly Gln Cys Glu Cys Arg Ala Asn Val Gln 
     930                935                940
Gly Gln Arg Cys Asp Lys Cys Lys Ala Gly Thr Phe Gly Leu Gln Ser 
 945                950                955                960
Ala Arg Gly Cys Val Pro Cys Asn Cys Asn Ser Phe Gly Ser Lys Ser 
                 965                970                975
Phe Asp Cys Glu Glu Ser Gly Gln Cys Trp Cys Gln Pro Gly Val Thr 
             980                985                990
Gly Lys Lys Cys Asp Arg Cys Ala His Gly Tyr Phe Asn Phe Gln Glu 
         995                1000                1005
Gly Gly Cys Thr Ala Cys Glu Cys Ser His Leu Gly Asn Asn Cys Asp 
     1010                1015                1020
Pro Lys Thr Gly Arg Cys Ile Cys Pro Pro Asn Thr Ile Gly Glu Lys 
 1025                1030                1035                1040
Cys Ser Lys Cys Ala Pro Asn Thr Trp Gly His Ser Ile Thr Thr Gly 
                 1045                1050                1055
Cys Lys Ala Cys Asn Cys Ser Thr Val Gly Ser Leu Asp Phe Gln Cys 
             1060                1065                1070
Asn Val Asn Thr Gly Gln Cys Asn Cys His Pro Lys Phe Ser Gly Ala 
         1075                1080                1085
Lys Cys Thr Glu Cys Ser Arg Gly His Trp Asn Tyr Pro Arg Cys Asn 
     1090                1095                1100
Leu Cys Asp Cys Phe Leu Pro Gly Thr Asp Ala Thr Thr Cys Asp Ser 
 1105                1110                1115                1120
Glu Thr Lys Lys Cys Ser Cys Ser Asp Gln Thr Gly Gln Cys Thr Cys 
                 1125                1130                1135
Lys Val Asn Val Glu Gly Ile His Cys Asp Arg Cys Arg Pro Gly Lys 
             1140                1145                1150
Phe Gly Leu Asp Ala Lys Asn Pro Leu Gly Cys Ser Ser Cys Tyr Cys 
         1155                1160                1165
Phe Gly Thr Thr Thr Gln Cys Ser Glu Ala Lys Gly Leu Ile Arg Thr 
     1170                1175                1180
Trp Val Thr Leu Lys Ala Glu Gln Thr Ile Leu Pro Leu Val Asp Glu 
 1185                1190                1195                1200
Ala Leu Gln His Thr Thr Thr Lys Gly Ile Val Phe Gln His Pro Glu 
                 1205                1210                1215
Ile Val Ala His Met Asp Leu Met Arg Glu Asp Leu His Leu Glu Pro 
             1220                1225                1230
Phe Tyr Trp Lys Leu Pro Glu Gln Phe Glu Gly Lys Lys Leu Met Ala 
         1235                1240                1245
Tyr Gly Gly Lys Leu Lys Tyr Ala Ile Tyr Phe Glu Ala Arg Glu Glu 
     1250                1255                1260
Thr Gly Phe Ser Thr Tyr Asn Pro Gln Val Ile Ile Arg Gly Gly Thr 
 1265                1270                1275                1280
Pro Thr His Ala Arg Ile Ile Val Arg His Met Ala Ala Pro Leu Ile 
                 1285                1290                1295
Gly Gln Leu Thr Arg His Glu Ile Glu Met Thr Glu Lys Glu Trp Lys 
             1300                1305                1310
Tyr Tyr Gly Asp Asp Pro Arg Val His Arg Thr Val Thr Arg Glu Asp 
         1315                1320                1325
Phe Leu Asp Ile Leu Tyr Asp Ile His Tyr Ile Leu Ile Lys Ala Thr 
     1330                1335                1340
Tyr Gly Asn Phe Met Arg Gln Ser Arg Ile Ser Glu Ile Ser Met Glu 
 1345                1350                1355                1360
Val Ala Glu Gln Gly Arg Gly Thr Thr Met Thr Pro Pro Ala Asp Leu 
                 1365                1370                1375
Ile Glu Lys Cys Asp Cys Pro Leu Gly Tyr Ser Gly Leu Ser Cys Glu 
             1380                1385                1390
Ala Cys Leu Pro Gly Phe Tyr Arg Leu Arg Ser Gln Pro Gly Gly Arg 
         1395                1400                1405
Thr Pro Gly Pro Thr Leu Gly Thr Cys Val Pro Cys Gln Cys Asn Gly 
     1410                1415                1420
His Ser Ser Leu Cys Asp Pro Glu Thr Ser Ile Cys Gln Asn Cys Gln 
 1425                1430                1435                1440
His His Thr Ala Gly Asp Phe Cys Glu Arg Cys Ala Leu Gly Tyr Tyr 
                 1445                1450                1455
Gly Ile Val Lys Gly Leu Pro Asn Asp Cys Gln Gln Cys Ala Cys Pro 
             1460                1465                1470
Leu Ile Ser Ser Ser Asn Asn Phe Ser Pro Ser Cys Val Ala Glu Gly 
         1475                1480                1485
Leu Asp Asp Tyr Arg Cys Thr Ala Cys Pro Arg Gly Tyr Glu Gly Gln 
     1490                1495                1500
Tyr Cys Glu Arg Cys Ala Pro Gly Tyr Thr Gly Ser Pro Gly Asn Pro 
 1505                1510                1515                1520
Gly Gly Ser Cys Gln Glu Cys Glu Cys Asp Pro Tyr Gly Ser Leu Pro 
                 1525                1530                1535
Val Pro Cys Asp Pro Val Thr Gly Phe Cys Thr Cys Arg Pro Gly Ala 
             1540                1545                1550
Thr Gly Arg Lys Cys Asp Gly Cys Lys His Trp His Ala Arg Glu Gly 
         1555                1560                1565
Trp Glu Cys Val Phe Cys Gly Asp Glu Cys Thr Gly Leu Leu Leu Gly 
     1570                1575                1580
Asp Leu Ala Arg Leu Glu Gln Met Val Met Ser Ile Asn Leu Thr Gly 
 1585                1590                1595                1600
Pro Leu Pro Ala Pro Tyr Lys Met Leu Tyr Gly Leu Glu Asn Met Thr 
                 1605                1610                1615
Gln Glu Leu Lys His Leu Leu Ser Pro Gln Arg Ala Pro Glu Arg Leu 
             1620                1625                1630
Ile Gln Leu Ala Glu Gly Asn Leu Asn Thr Leu Val Thr Glu Met Asn 
         1635                1640                1645
Glu Leu Leu Thr Arg Ala Thr Lys Val Thr Ala Asp Gly Glu Gln Thr 
     1650                1655                1660
Gly Gln Asp Ala Glu Arg Thr Asn Thr Arg Ala Lys Ser Leu Gly Glu 
 1665                1670                1675                1680
Phe Ile Lys Glu Leu Ala Arg Asp Ala Glu Ala Val Asn Glu Lys Ala 
                 1685                1690                1695
Ile Lys Leu Asn Glu Thr Leu Gly Thr Arg Asp Glu Ala Phe Glu Arg 
             1700                1705                1710
Asn Leu Glu Gly Leu Gln Lys Glu Ile Asp Gln Met Ile Lys Glu Leu 
         1715                1720                1725
Arg Arg Lys Asn Leu Glu Thr Gln Lys Glu Ile Ala Glu Asp Glu Leu 
     1730                1735                1740
Val Ala Ala Glu Ala Leu Leu Lys Lys Val Lys Lys Leu Phe Gly Glu 
 1745                1750                1755                1760
Ser Arg Gly Glu Asn Glu Glu Met Glu Lys Asp Leu Arg Glu Lys Leu 
                 1765                1770                1775
Ala Asp Tyr Lys Asn Lys Val Asp Asp Ala Trp Asp Leu Leu Arg Glu 
             1780                1785                1790
Ala Thr Asp Lys Ile Arg Glu Ala Asn Arg Leu Phe Ala Val Asn Gln 
         1795                1800                1805
Lys Asn Met Thr Ala Leu Glu Lys Lys Lys Glu Ala Val Glu Ser Gly 
     1810                1815                1820
Lys Arg Gln Ile Glu Asn Thr Leu Lys Glu Gly Asn Asp Ile Leu Asp 
 1825                1830                1835                1840
Glu Ala Asn Arg Leu Ala Asp Glu Ile Asn Ser Ile Ile Asp Tyr Val 
                 1845                1850                1855
Glu Asp Ile Gln Thr Lys Leu Pro Pro Met Ser Glu Glu Leu Asn Asp 
             1860                1865                1870
Lys Ile Asp Asp Leu Ser Gln Glu Ile Lys Asp Arg Lys Leu Ala Glu 
         1875                1880                1885
Lys Val Ser Gln Ala Glu Ser His Ala Ala Gln Leu Asn Asp Ser Ser 
     1890                1895                1900
Ala Val Leu Asp Gly Ile Leu Asp Glu Ala Lys Asn Ile Ser Phe Asn 
 1905                1910                1915                1920
Ala Thr Ala Ala Phe Lys Ala Tyr Ser Asn Ile Lys Asp Tyr Ile Asp 
                 1925                1930                1935
Glu Ala Glu Lys Val Ala Lys Glu Ala Lys Asp Leu Ala His Glu Ala 
             1940                1945                1950
Thr Lys Leu Ala Thr Gly Pro Arg Gly Leu Leu Lys Glu Asp Ala Lys 
         1955                1960                1965
Gly Cys Leu Gln Lys Ser Phe Arg Ile Leu Asn Glu Ala Lys Lys Leu 
     1970                1975                1980
Ala Asn Asp Val Lys Glu Asn Glu Asp His Leu Asn Gly Leu Lys Thr 
 1985                1990                1995                2000
Arg Ile Glu Asn Ala Asp Ala Arg Asn Gly Asp Leu Leu Arg Thr Leu 
                 2005                2010                2015
Asn Asp Thr Leu Gly Lys Leu Ser Ala Ile Pro Asn Asp Thr Ala Ala 
             2020                2025                2030
Lys Leu Gln Ala Val Lys Asp Lys Ala Arg Gln Ala Asn Asp Thr Ala 
         2035                2040                2045
Lys Asp Val Leu Ala Gln Ile Thr Glu Leu His Gln Asn Leu Asp Gly 
     2050                2055                2060
Leu Lys Lys Asn Tyr Asn Lys Leu Ala Asp Ser Val Ala Lys Thr Asn 
 2065                2070                2075                2080
Ala Val Val Lys Asp Pro Ser Lys Asn Ser Lys Ile Ala Asp Ala Asp 
                 2085                2090                2095
Ala Thr Val Lys Asn Leu Glu Gln Glu Ala Asp Arg Leu Ile Asp Lys 
             2100                2105                2110
Leu Lys Pro Ile Lys Glu Leu Glu Asp Asn Leu Lys Lys Asn Ile Ser 
         2115                2120                2125
Glu Ile Lys Glu Leu Ile Asn Gln Ala Arg Lys Gln Ala Asn Ser Ile 
     2130                2135                2140
Lys Val Ser Val Ser Ser Gly Gly Asp Cys Ile Arg Thr Tyr Lys Pro 
 2145                2150                2155                2160
Glu Ile Lys Lys Gly Ser Tyr Asn Asn Ile Val Val Asn Val Lys Thr 
                 2165                2170                2175
Ala Val Ala Asp Asn Leu Leu Phe Tyr Leu Gly Ser Ala Lys Phe Ile 
             2180                2185                2190
Asp Phe Leu Ala Ile Glu Met Arg Lys Gly Lys Val Ser Phe Leu Trp 
         2195                2200                2205
Asp Val Gly Ser Gly Val Gly Arg Val Glu Tyr Pro Asp Leu Thr Ile 
     2210                2215                2220
Asp Asp Ser Tyr Trp Tyr Arg Ile Val Ala Ser Arg Thr Gly Arg Asn 
 2225                2230                2235                2240
Gly Thr Ile Ser Val Arg Ala Leu Asp Gly Pro Lys Ala Ser Ile Val 
                 2245                2250                2255
Pro Ser Thr His His Ser Thr Ser Pro Pro Gly Tyr Thr Ile Leu Asp 
             2260                2265                2270
Val Asp Ala Asn Ala Met Leu Phe Val Gly Gly Leu Thr Gly Lys Leu 
         2275                2280                2285
Lys Lys Ala Asp Ala Val Arg Val Ile Thr Phe Thr Gly Cys Met Gly 
     2290                2295                2300
Glu Thr Tyr Phe Asp Asn Lys Pro Ile Gly Leu Trp Asn Phe Arg Glu 
 2305                2310                2315                2320
Lys Glu Gly Asp Cys Lys Gly Cys Thr Val Ser Pro Gln Val Glu Asp 
                 2325                2330                2335
Ser Glu Gly Thr Ile Gln Phe Asp Gly Glu Gly Tyr Ala Leu Val Ser 
             2340                2345                2350
Arg Pro Ile Arg Trp Tyr Pro Asn Ile Ser Thr Val Met Phe Lys Phe 
         2355                2360                2365
Arg Thr Phe Ser Ser Ser Ala Leu Leu Met Tyr Leu Ala Thr Arg Asp 
     2370                2375                2380
Leu Arg Asp Phe Met Ser Val Glu Leu Thr Asp Gly His Ile Lys Val 
 2385                2390                2395                2400
Ser Tyr Asp Leu Gly Ser Gly Met Ala Ser Val Val Ser Asn Gln Asn 
                 2405                2410                2415
His Asn Asp Gly Lys Trp Lys Ser Phe Thr Leu Ser Arg Ile Gln Lys 
             2420                2425                2430
Gln Ala Asn Ile Ser Ile Val Asp Ile Asp Thr Asn Gln Glu Glu Asn 
         2435                2440                2445
Ile Ala Thr Ser Ser Ser Gly Asn Asn Phe Gly Leu Asp Leu Lys Ala 
     2450                2455                2460
Asp Asp Lys Ile Tyr Phe Gly Gly Leu Pro Thr Leu Arg Asn Leu Ser 
 2465                2470                2475                2480
Met Lys Ala Arg Pro Glu Val Asn Leu Lys Lys Tyr Ser Gly Cys Leu 
                 2485                2490                2495
Lys Asp Ile Glu Ile Ser Arg Thr Pro Tyr Asn Ile Leu Ser Ser Pro 
             2500                2505                2510
Asp Tyr Val Gly Val Thr Lys Gly Cys Ser Leu Glu Asn Val Tyr Thr 
         2515                2520                2525
Val Ser Phe Pro Lys Pro Gly Phe Val Glu Leu Ser Pro Val Pro Ile 
     2530                2535                2540
Asp Val Gly Thr Glu Ile Asn Leu Ser Phe Ser Thr Lys Asn Glu Ser 
 2545                2550                2555                2560
Gly Ile Ile Leu Leu Gly Ser Gly Gly Thr Pro Ala Pro Pro Arg Arg 
                 2565                2570                2575
Lys Arg Arg Gln Thr Gly Gln Ala Tyr Tyr Ala Ile Leu Leu Asn Arg 
             2580                2585                2590
Gly Arg Leu Glu Val His Leu Ser Thr Gly Ala Arg Thr Met Arg Lys 
         2595                2600                2605
Ile Val Ile Arg Pro Glu Pro Asn Leu Phe His Asp Gly Arg Glu His 
     2610                2615                2620
Ser Val His Val Glu Arg Thr Arg Gly Ile Phe Thr Val Gln Val Asp 
 2625                2630                2635                2640
Glu Asn Arg Arg Tyr Met Gln Asn Leu Thr Val Glu Gln Pro Ile Glu 
                 2645                2650                2655
Val Lys Lys Leu Phe Val Gly Gly Ala Pro Pro Glu Phe Gln Pro Ser 
             2660                2665                2670
Pro Leu Arg Asn Ile Pro Pro Phe Glu Gly Cys Ile Trp Asn Leu Val 
         2675                2680                2685
Ile Asn Ser Val Pro Met Asp Phe Ala Arg Pro Val Ser Phe Lys Asn 
     2690                2695                2700
Ala Asp Ile Gly Arg Cys Ala His Gln Lys Leu Arg Glu Asp Glu Asp 
 2705                2710                2715                2720
Gly Ala Ala Pro Ala Glu Ile Val Ile Gln Pro Glu Pro Val Pro Thr 
                 2725                2730                2735
Pro Ala Phe Pro Thr Pro Thr Pro Val Leu Thr His Gly Pro Cys Ala 
             2740                2745                2750
Ala Glu Ser Glu Pro Ala Leu Leu Ile Gly Ser Lys Gln Phe Gly Leu 
         2755                2760                2765
Ser Arg Asn Ser His Ile Ala Ile Ala Phe Asp Asp Thr Lys Val Lys 
     2770                2775                2780
Asn Arg Leu Thr Ile Glu Leu Glu Val Arg Thr Glu Ala Glu Ser Gly 
 2785                2790                2795                2800
Leu Leu Phe Tyr Met Ala Arg Ile Asn His Ala Asp Phe Ala Thr Val 
                 2805                2810                2815
Gln Leu Arg Asn Gly Leu Pro Tyr Phe Ser Tyr Asp Leu Gly Ser Gly 
             2820                2825                2830
Asp Thr His Thr Met Ile Pro Thr Lys Ile Asn Asp Gly Gln Trp His 
         2835                2840                2845
Lys Ile Lys Ile Met Arg Ser Lys Gln Glu Gly Ile Leu Tyr Val Asp 
     2850                2855                2860
Gly Ala Ser Asn Arg Thr Ile Ser Pro Lys Lys Ala Asp Ile Leu Asp 
 2865                2870                2875                2880
Val Val Gly Met Leu Tyr Val Gly Gly Leu Pro Ile Asn Tyr Thr Thr 
                 2885                2890                2895
Arg Arg Ile Gly Pro Val Thr Tyr Ser Ile Asp Gly Cys Val Arg Asn 
             2900                2905                2910
Leu His Met Ala Glu Ala Pro Ala Asp Leu Glu Gln Pro Thr Ser Ser 
         2915                2920                2925
Phe His Val Gly Thr Cys Phe Ala Asn Ala Gln Arg Gly Thr Tyr Phe 
     2930                2935                2940
Asp Gly Thr Gly Phe Ala Lys Ala Val Gly Gly Phe Lys Val Gly Leu 
 2945                2950                2955                2960
Asp Leu Leu Val Glu Phe Glu Phe Arg Thr Thr Thr Thr Thr Gly Val 
                 2965                2970                2975
Leu Leu Gly Ile Ser Ser Gln Lys Met Asp Gly Met Gly Ile Glu Met 
             2980                2985                2990
Ile Asp Glu Lys Leu Met Phe His Val Asp Asn Gly Ala Gly Arg Phe 
         2995                3000                3005
Thr Ala Val Tyr Asp Ala Gly Val Pro Gly His Leu Cys Asp Gly Gln 
     3010                3015                3020
Trp His Lys Val Thr Ala Asn Lys Ile Lys His Arg Ile Glu Leu Thr 
 3025                3030                3035                3040
Val Asp Gly Asn Gln Val Glu Ala Gln Ser Pro Asn Pro Ala Ser Thr 
                 3045                3050                3055
Ser Ala Asp Thr Asn Asp Pro Val Phe Val Gly Gly Phe Pro Asp Asp 
             3060                3065                3070
Leu Lys Gln Phe Gly Leu Thr Thr Ser Ile Pro Phe Arg Gly Cys Ile 
         3075                3080                3085
Arg Ser Leu Lys Leu Thr Lys Gly Thr Gly Lys Pro Leu Glu Val Asn 
     3090                3095                3100
Phe Ala Lys Ala Leu Glu Leu Arg Gly Val Gln Pro Val Ser Cys Pro 
 3105                3110                3115                3120
Ala Asn 
                 3125



<210> 7722
<211> 695
<212> DNA
<213> Rattus norvegicus
<308> S73007
<400> 7722

accccagtc  acgaaatta  attggggaa  acaggagga  tcagagttc  gcggaagcc  60
agagagccg  gtggagcaa  gatacatct  tagccatgg  tgtgttcat  aaaggactt  120
caaaggcca  ggagggagt  gtggctgct  ctgagaaaa  caagcaggg  gtggcagag  180
cagctggga  gacaaaaga  ggcgtcctc  atgtaggtt  caaaactaa  gagggagtc  240
ttcatggag  gacaacagt  gctgagaag  ccaaagagc  agtgacaaa  gttggaggg  300
cagtggtga  tggtgtgac  gcagtcgct  agaagacag  ggagggagc  gggaacatt  360
ctgctgcca  tggttttgt  aagaaggac  agatgggca  gggtgaaga  gggtaccca  420
aagagggaa  cctggaaga  atgcctgtg  accctagca  tgaggctta  gaaatgcct  480
cagaggaag  ctaccaaga  tatgagcct  aagcctaag  atgtcgttg  acctactgt  540
ctaagatct  cccaggtgt  cttccatgg  gtacaagtg  tcagttcca  cgtgctgat  600
tttcaaagc  tttagattg  acagattat  aaaactgga  gaggaaacg  tgccatccc  660
cttcacctt  gtttaccag  tgttcttgt  acatt  695



<210> 7723
<211> 140
<212> PRT
<213> Rattus norvegicus
<308> AAB20688
<400> 7723

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
  1               5                  10                  15
Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
             20                  25                  30
Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
         35                  40                  45
Val His Gly Val Thr Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
     50                  55                  60
Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
 65                  70                  75                  80
Thr Val Glu Gly Ala Gly Asn Ile Ala Ala Ala Thr Gly Phe Val Lys 
                 85                  90                  95
Lys Asp Gln Met Gly Lys Gly Glu Glu Gly Tyr Pro Gln Glu Gly Ile 
             100                105                110
Leu Glu Asp Met Pro Val Asp Pro Ser Ser Glu Ala Tyr Glu Met Pro 
         115                120                125
Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
     130                135                140



<210> 7724
<211> 1543
<212> DNA
<213> Homo sapiens
<308> NM_000345
<400> 7724

ggagtggcc  ttcgacgac  gtgtggtgt  aaggaattc  ttagccatg  atgtattca  60
gaaaggact  tcaaaggcc  aggagggag  tgtggctgc  gctgagaaa  ccaaacagg  120
tgtggcaga  gcagcagga  agacaaaag  gggtgttct  tatgtaggc  ccaaaacca  180
ggagggagt  gtgcatggt  tggcaacag  ggctgagaa  accaaagag  aagtgacaa  240
tgttggagg  gcagtggtg  cgggtgtga  agcagtagc  cagaagaca  tggagggag  300
agggagcat  gcagcagcc  ctggctttg  caaaaagga  cagttgggc  agaatgaag  360
aggagcccc  caggaagga  ttctggaag  tatgcctgt  gatcctgac  atgaggctt  420
tgaaatgcc  tctgaggaa  ggtatcaag  ctacgaacc  gaagcctaa  aaatatctt  480
gctcccagt  tcttgagat  tgctgacag  tgttccatc  tgtacaagt  ctcagttcc  540
atgtgccca  tcatgacat  tctcaaagt  tttacagtg  atctcgaag  cttccatca  600
cagtgattg  agtatctgt  cctgccccc  ctcagcatt  cggtgcttc  ctttcactg  660
agtgaatac  tggtagcag  gtctttgtg  gctgtggat  ttgtggctt  aatctacga  720
gttaaaaca  attaaaaac  cctaagtga  taccactta  ttctaaatc  tcactattt  780
tttgttgct  ttgttcaga  gttgttagt  atttgctat  atatattat  agattttta  840
gtgtctttt  atgatactg  ctaagaata  tgacgtatt  tgaaatttg  taatatata  900
aatacttaa  aatatgtga  catgaaact  tgcacctat  aatactaaa  atgaaattt  960
accattttg  gatgtgttt  attcacttg  gtttgtata  aaatggtga  aattaaaat  1020
aaacgttat  tcattgcaa  aatatttta  ttttatccc  tctcacttt  ataataaaa  1080
tcatgctta  aagcaacat  aattaagaa  tgacacaaa  gacaaaaat  taaagttat  1140
aatagccat  tgaagaagg  ggaatttta  aagaggtag  gaaaatgga  cattaaccc  1200
acactcgga  ttccctgaa  caacactgc  agaagtgtg  tttggtatg  actggttcc  1260
taagtggct  tgattaatt  ttgaaagtg  ggtgttgaa  accccaact  ctattgtag  1320
gtggtctat  tctcccttc  atcctgtca  tgtttgctt  atgtatttt  gggaactgt  1380
gtttgatgt  tatgtgttt  taattgtta  acattttta  ttgagcctt  tattaacat  1440
tattgttat  tttgtctcg  aataatttt  tagttaaaa  ctattttgt  tgatattgg  1500
gtgaatgct  tacctttct  acaataaat  atattcgac  atg  1543



<210> 7725
<211> 140
<212> PRT
<213> Homo sapiens
<308> P37840
<400> 7725

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
  1               5                  10                  15
Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
             20                  25                  30
Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
         35                  40                  45
Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
     50                  55                  60
Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
 65                  70                  75                  80
Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                 85                  90                  95
Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
             100                105                110
Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
         115                120                125
Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
     130                135                140



<210> 7726
<211> 525
<212> DNA
<213> Rattus norvegicus
<308> S73424
<400> 7726

cgcgcttta  accgtcctc  ggccgtcgc  cgcagtctc  ccgccacca  gcctatgtt  60
atcgtgaac  ccaatgttc  ccgcgcctc  gtgccagag  ggtttctct  cgagctcac  120
cagcagctg  cgcaggcca  cggcaagcc  gcacagtac  tcgcagtgc  cgtggtccc  180
gaccagctc  tgactttta  tggcacgag  gacccctgc  ccctctgca  cctgcacag  240
atcggcaag  tcggtggcg  ccagaaccg  aactacagc  agctgctgt  cggcctgct  300
tccgatcgc  tgcacatca  cccggaccg  gtctacatc  actattacg  catgaacgc  360
gccaacgtg  gctggaacg  ttccacctt  gcttgagcc  gggcctcac  tacctgcac  420
gctgttctt  gagtcttgc  gcacgcccc  ttctgtgtt  atccacccg  aatgatggc  480
accttccgg  cgggagaaa  aaatggttt  agaccaaaa  aaaaa  525



<210> 7727
<211> 114
<212> PRT
<213> Rattus norvegicus
<308> AAB32392
<400> 7727

Pro Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro Glu 
  1               5                  10                  15
Gly Phe Leu Ser Glu Leu Thr Gln Gln Leu Ala Gln Ala Thr Gly Lys 
             20                  25                  30
Pro Ala Gln Tyr Ile Ala Val His Val Val Pro Asp Gln Leu Met Thr 
         35                  40                  45
Phe Ser Gly Thr Ser Asp Pro Cys Ala Leu Cys Ser Leu His Ser Ile 
     50                  55                  60
Gly Lys Ile Gly Gly Ala Gln Asn Arg Asn Tyr Ser Lys Leu Leu Cys 
 65                  70                  75                  80
Gly Leu Leu Ser Asp Arg Leu His Ile Ser Pro Asp Arg Val Tyr Ile 
                 85                  90                  95
Asn Tyr Tyr Asp Met Asn Ala Ala Asn Val Gly Trp Asn Gly Ser Thr 
             100                105                110
Phe Ala 
         115



<210> 7728
<211> 561
<212> DNA
<213> Homo sapiens
<308> NM_002415
<400> 7728

accacagtg  tgtccgaga  gtcaggcac  tagctcagc  gcggccgcg  cgcgtgcgt  60
tgtgcctct  cgcgggtct  ctggtcctt  tgccatcat  ccgatgttc  tcgtaaaca  120
caacgtgcc  cgcgcctcc  tgccggacg  gttcctctc  gagctcacc  agcagctgg  180
gcaggccac  ggcaagccc  cccagtaca  cgcggtgca  gtggtcccg  accagctca  240
ggccttcgg  ggctccagc  agccgtgcg  gctctgcag  ctgcacagc  tcggcaaga  300
cggcggcgc  cagaaccgc  cctacagca  gctgctgtg  ggcctgctg  ccgagcgcc  360
gcgcatcag  ccggacagg  tctacatca  ctattacga  atgaacgcg  ccaatgtgg  420
ctggaacaa  tccaccttc  cctaagagc  gcagggacc  acgctgtct  cgctggctc  480
acccgggaa  ccgccgcac  ctgtgttct  ggcccgccc  ccccaacct  ctggtgggg  540
gaaataaac  gtttagaga  t  561



<210> 7729
<211> 114
<212> PRT
<213> Homo sapiens
<308> P14174
<400> 7729

Pro Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro Asp 
  1               5                  10                  15
Gly Phe Leu Ser Glu Leu Thr Gln Gln Leu Ala Gln Ala Thr Gly Lys 
             20                  25                  30
Pro Pro Gln Tyr Ile Ala Val His Val Val Pro Asp Gln Leu Met Ala 
         35                  40                  45
Phe Gly Gly Ser Ser Glu Pro Cys Ala Leu Cys Ser Leu His Ser Ile 
     50                  55                  60
Gly Lys Ile Gly Gly Ala Gln Asn Arg Ser Tyr Ser Lys Leu Leu Cys 
 65                  70                  75                  80
Gly Leu Leu Ala Glu Arg Leu Arg Ile Ser Pro Asp Arg Val Tyr Ile 
                 85                  90                  95
Asn Tyr Tyr Asp Met Asn Ala Ala Asn Val Gly Trp Asn Asn Ser Thr 
             100                105                110
Phe Ala 
         115



<210> 7730
<211> 1503
<212> DNA
<213> Rattus norvegicus
<308> S74572
<400> 7730

ctaaacatg  gtgcatttt  ggataaacc  aaaactgaa  agcacaatg  tcacggtgc  60
gggaacggt  tgcgttacg  tctgagcag  atgcaagga  ggagagtag  aatggaaga  120
gcacacact  ctgttgtgg  aattcctca  ggcttggag  actggtcgt  ttttgcagt  180
tatgatggt  atgctggat  ccgagtggc  aattactgt  caacacatc  attagaaca  240
atcactacc  atgaagact  tagggctgc  gacaaatca  gctttgctc  tgagccgtc  300
gtggaaaat  ttaagactg  tatccgaac  ggctttttg  aaattgatg  atatatgcg  360
aacttttca  acctgagga  cgggatgga  aggagcggc  ctaccgcag  gggcgtgat  420
atttcaccg  cacacatct  ctttatcaa  tgcggtgac  cgagagctg  tctatgtag  480
aatggacaa  tctgctttt  aacccagga  cacaaacct  gtaatccaa  ggaaaagga  540
cgcatccaa  atgcaggag  cagtgtaat  atacagcgt  tgaatgggt  gttagcagt  600
tctcgtgct  tgggggact  tgattacaa  tgtgttgat  gcaagggcc  cacagagca  660
cttgtttct  cagagcctg  ggtttatga  attctaaga  cagaagagg  tgaatttgt  720
gtcctggct  gtgatggga  ctgggatgt  atgagcaat  aggagctct  tgagtttgt  780
aactctagg  ttgaggtgt  agacgacct  gagaatgtg  gcaattggg  agtggacac  840
tgtttacat  agggaagtc  agataacat  agtattgtg  tagtttgct  tgcaaatgc  900
cccaaggtc  cagatgaag  cgtgaaaag  gatttagag  tggacaagc  cttggaatc  960
cgggtggaa  aaatcatgc  gaagtctgg  gaggaagga  tgcctgatc  tgcccatgt  1020
atgcgcatt  tgtctgcag  aaatatccc  aatttacct  ccgggggag  cctcgctgg  1080
aagcgcaat  ttattgaag  tgtttatag  agacttaat  caaacaaag  caatgatgg  1140
ttttaccaa  cttcaactc  atacagtga  aatgtttcc  attatgaat  gcagacttg  1200
gcacgtcta  ttgtaaagc  agctgagaa  tctggtgac  cagcagagg  tgatcaacc  1260
accaagagc  cggaagtac  aagaagaac  aaagttttg  tttgttttt  taaactcga  1320
agaaaaaaa  aagtccagc  ttacgtcag  gcggtatct  ttcgctgtg  gcggtaacc  1380
tctagccca  cagcgaagg  ggaggagag  tcccacctt  ccttacaaa  cttgctttt  1440
catgttcat  caataaaca  gtttggctt  ttggtaaaa  accgaattg  gctgcagga  1500
ttc  1503



<210> 7731
<211> 390
<212> PRT
<213> Rattus norvegicus
<308> AAB33430
<400> 7731

Met Gly Ala Phe Leu Asp Lys Pro Lys Thr Glu Lys His Asn Ala His 
  1               5                  10                  15
Gly Ala Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
             20                  25                  30
Arg Val Glu Met Glu Asp Ala His Thr Ala Val Val Gly Ile Pro His 
         35                  40                  45
Gly Leu Glu Asp Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
     50                  55                  60
Ser Arg Val Ala Asn Tyr Cys Ser Thr His Leu Leu Glu His Ile Thr 
 65                  70                  75                  80
Thr Asn Glu Asp Phe Arg Ala Ala Asp Lys Ser Gly Phe Ala Leu Glu 
                 85                  90                  95
Pro Ser Val Glu Asn Val Lys Thr Gly Ile Arg Thr Gly Phe Leu Lys 
             100                105                110
Ile Asp Glu Tyr Met Arg Asn Phe Ser Asp Leu Arg Asn Gly Met Asp 
         115                120                125
Arg Ser Gly Ser Thr Ala Val Gly Val Met Ile Ser Pro Thr His Ile 
     130                135                140
Tyr Phe Ile Asn Cys Gly Asp Ser Arg Ala Val Leu Cys Arg Asn Gly 
 145                150                155                160
Gln Val Cys Phe Ser Thr Gln Asp His Lys Pro Cys Asn Pro Met Glu 
                 165                170                175
Lys Glu Arg Ile Gln Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val 
             180                185                190
Asn Gly Ser Leu Ala Val Ser Arg Ala Leu Gly Asp Tyr Asp Tyr Lys 
         195                200                205
Cys Val Asp Gly Lys Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro 
     210                215                220
Glu Val Tyr Glu Ile Leu Arg Ala Glu Glu Asp Glu Phe Val Val Leu 
 225                230                235                240
Ala Cys Asp Gly Ile Trp Asp Val Met Ser Asn Glu Glu Leu Cys Glu 
                 245                250                255
Phe Val Asn Ser Arg Leu Glu Val Ser Asp Asp Leu Glu Asn Val Cys 
             260                265                270
Asn Trp Val Val Asp Thr Cys Leu His Lys Gly Ser Arg Asp Asn Met 
         275                280                285
Ser Ile Val Leu Val Cys Phe Ala Asn Ala Pro Lys Val Ser Asp Glu 
     290                295                300
Ala Val Lys Arg Asp Leu Glu Leu Asp Lys His Leu Glu Ser Arg Val 
 305                310                315                320
Glu Glu Ile Met Gln Lys Ser Gly Glu Glu Gly Met Pro Asp Leu Ala 
                 325                330                335
His Val Met Arg Ile Leu Ser Ala Glu Asn Ile Pro Asn Leu Pro Pro 
             340                345                350
Gly Gly Gly Leu Ala Gly Lys Arg Asn Val Ile Glu Ala Val Tyr Ser 
         355                360                365
Arg Leu Asn Pro Asn Lys Asp Asn Asp Gly Gly Ala Gly Asp Leu Glu 
     370                375                380
Asp Ser Leu Val Ala Leu 
 385                390



<210> 7732
<211> 1503
<212> DNA
<213> Rattus norvegicus
<308> S74572
<400> 7732

ctaaacatg  gtgcatttt  ggataaacc  aaaactgaa  agcacaatg  tcacggtgc  60
gggaacggt  tgcgttacg  tctgagcag  atgcaagga  ggagagtag  aatggaaga  120
gcacacact  ctgttgtgg  aattcctca  ggcttggag  actggtcgt  ttttgcagt  180
tatgatggt  atgctggat  ccgagtggc  aattactgt  caacacatc  attagaaca  240
atcactacc  atgaagact  tagggctgc  gacaaatca  gctttgctc  tgagccgtc  300
gtggaaaat  ttaagactg  tatccgaac  ggctttttg  aaattgatg  atatatgcg  360
aacttttca  acctgagga  cgggatgga  aggagcggc  ctaccgcag  gggcgtgat  420
atttcaccg  cacacatct  ctttatcaa  tgcggtgac  cgagagctg  tctatgtag  480
aatggacaa  tctgctttt  aacccagga  cacaaacct  gtaatccaa  ggaaaagga  540
cgcatccaa  atgcaggag  cagtgtaat  atacagcgt  tgaatgggt  gttagcagt  600
tctcgtgct  tgggggact  tgattacaa  tgtgttgat  gcaagggcc  cacagagca  660
cttgtttct  cagagcctg  ggtttatga  attctaaga  cagaagagg  tgaatttgt  720
gtcctggct  gtgatggga  ctgggatgt  atgagcaat  aggagctct  tgagtttgt  780
aactctagg  ttgaggtgt  agacgacct  gagaatgtg  gcaattggg  agtggacac  840
tgtttacat  agggaagtc  agataacat  agtattgtg  tagtttgct  tgcaaatgc  900
cccaaggtc  cagatgaag  cgtgaaaag  gatttagag  tggacaagc  cttggaatc  960
cgggtggaa  aaatcatgc  gaagtctgg  gaggaagga  tgcctgatc  tgcccatgt  1020
atgcgcatt  tgtctgcag  aaatatccc  aatttacct  ccgggggag  cctcgctgg  1080
aagcgcaat  ttattgaag  tgtttatag  agacttaat  caaacaaag  caatgatgg  1140
ttttaccaa  cttcaactc  atacagtga  aatgtttcc  attatgaat  gcagacttg  1200
gcacgtcta  ttgtaaagc  agctgagaa  tctggtgac  cagcagagg  tgatcaacc  1260
accaagagc  cggaagtac  aagaagaac  aaagttttg  tttgttttt  taaactcga  1320
agaaaaaaa  aagtccagc  ttacgtcag  gcggtatct  ttcgctgtg  gcggtaacc  1380
tctagccca  cagcgaagg  ggaggagag  tcccacctt  ccttacaaa  cttgctttt  1440
catgttcat  caataaaca  gtttggctt  ttggtaaaa  accgaattg  gctgcagga  1500
ttc  1503



<210> 7733
<211> 390
<212> PRT
<213> Rattus norvegicus
<308> AAB33430
<400> 7733

Met Gly Ala Phe Leu Asp Lys Pro Lys Thr Glu Lys His Asn Ala His 
  1               5                  10                  15
Gly Ala Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
             20                  25                  30
Arg Val Glu Met Glu Asp Ala His Thr Ala Val Val Gly Ile Pro His 
         35                  40                  45
Gly Leu Glu Asp Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
     50                  55                  60
Ser Arg Val Ala Asn Tyr Cys Ser Thr His Leu Leu Glu His Ile Thr 
 65                  70                  75                  80
Thr Asn Glu Asp Phe Arg Ala Ala Asp Lys Ser Gly Phe Ala Leu Glu 
                 85                  90                  95
Pro Ser Val Glu Asn Val Lys Thr Gly Ile Arg Thr Gly Phe Leu Lys 
             100                105                110
Ile Asp Glu Tyr Met Arg Asn Phe Ser Asp Leu Arg Asn Gly Met Asp 
         115                120                125
Arg Ser Gly Ser Thr Ala Val Gly Val Met Ile Ser Pro Thr His Ile 
     130                135                140
Tyr Phe Ile Asn Cys Gly Asp Ser Arg Ala Val Leu Cys Arg Asn Gly 
 145                150                155                160
Gln Val Cys Phe Ser Thr Gln Asp His Lys Pro Cys Asn Pro Met Glu 
                 165                170                175
Lys Glu Arg Ile Gln Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val 
             180                185                190
Asn Gly Ser Leu Ala Val Ser Arg Ala Leu Gly Asp Tyr Asp Tyr Lys 
         195                200                205
Cys Val Asp Gly Lys Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro 
     210                215                220
Glu Val Tyr Glu Ile Leu Arg Ala Glu Glu Asp Glu Phe Val Val Leu 
 225                230                235                240
Ala Cys Asp Gly Ile Trp Asp Val Met Ser Asn Glu Glu Leu Cys Glu 
                 245                250                255
Phe Val Asn Ser Arg Leu Glu Val Ser Asp Asp Leu Glu Asn Val Cys 
             260                265                270
Asn Trp Val Val Asp Thr Cys Leu His Lys Gly Ser Arg Asp Asn Met 
         275                280                285
Ser Ile Val Leu Val Cys Phe Ala Asn Ala Pro Lys Val Ser Asp Glu 
     290                295                300
Ala Val Lys Arg Asp Leu Glu Leu Asp Lys His Leu Glu Ser Arg Val 
 305                310                315                320
Glu Glu Ile Met Gln Lys Ser Gly Glu Glu Gly Met Pro Asp Leu Ala 
                 325                330                335
His Val Met Arg Ile Leu Ser Ala Glu Asn Ile Pro Asn Leu Pro Pro 
             340                345                350
Gly Gly Gly Leu Ala Gly Lys Arg Asn Val Ile Glu Ala Val Tyr Ser 
         355                360                365
Arg Leu Asn Pro Asn Lys Asp Asn Asp Gly Gly Ala Gly Asp Leu Glu 
     370                375                380
Asp Ser Leu Val Ala Leu 
 385                390



<210> 7734
<211> 1503
<212> DNA
<213> Rattus norvegicus
<308> S74572
<400> 7734

ctaaacatg  gtgcatttt  ggataaacc  aaaactgaa  agcacaatg  tcacggtgc  60
gggaacggt  tgcgttacg  tctgagcag  atgcaagga  ggagagtag  aatggaaga  120
gcacacact  ctgttgtgg  aattcctca  ggcttggag  actggtcgt  ttttgcagt  180
tatgatggt  atgctggat  ccgagtggc  aattactgt  caacacatc  attagaaca  240
atcactacc  atgaagact  tagggctgc  gacaaatca  gctttgctc  tgagccgtc  300
gtggaaaat  ttaagactg  tatccgaac  ggctttttg  aaattgatg  atatatgcg  360
aacttttca  acctgagga  cgggatgga  aggagcggc  ctaccgcag  gggcgtgat  420
atttcaccg  cacacatct  ctttatcaa  tgcggtgac  cgagagctg  tctatgtag  480
aatggacaa  tctgctttt  aacccagga  cacaaacct  gtaatccaa  ggaaaagga  540
cgcatccaa  atgcaggag  cagtgtaat  atacagcgt  tgaatgggt  gttagcagt  600
tctcgtgct  tgggggact  tgattacaa  tgtgttgat  gcaagggcc  cacagagca  660
cttgtttct  cagagcctg  ggtttatga  attctaaga  cagaagagg  tgaatttgt  720
gtcctggct  gtgatggga  ctgggatgt  atgagcaat  aggagctct  tgagtttgt  780
aactctagg  ttgaggtgt  agacgacct  gagaatgtg  gcaattggg  agtggacac  840
tgtttacat  agggaagtc  agataacat  agtattgtg  tagtttgct  tgcaaatgc  900
cccaaggtc  cagatgaag  cgtgaaaag  gatttagag  tggacaagc  cttggaatc  960
cgggtggaa  aaatcatgc  gaagtctgg  gaggaagga  tgcctgatc  tgcccatgt  1020
atgcgcatt  tgtctgcag  aaatatccc  aatttacct  ccgggggag  cctcgctgg  1080
aagcgcaat  ttattgaag  tgtttatag  agacttaat  caaacaaag  caatgatgg  1140
ttttaccaa  cttcaactc  atacagtga  aatgtttcc  attatgaat  gcagacttg  1200
gcacgtcta  ttgtaaagc  agctgagaa  tctggtgac  cagcagagg  tgatcaacc  1260
accaagagc  cggaagtac  aagaagaac  aaagttttg  tttgttttt  taaactcga  1320
agaaaaaaa  aagtccagc  ttacgtcag  gcggtatct  ttcgctgtg  gcggtaacc  1380
tctagccca  cagcgaagg  ggaggagag  tcccacctt  ccttacaaa  cttgctttt  1440
catgttcat  caataaaca  gtttggctt  ttggtaaaa  accgaattg  gctgcagga  1500
ttc  1503



<210> 7735
<211> 390
<212> PRT
<213> Rattus norvegicus
<308> AAB33430
<400> 7735

Met Gly Ala Phe Leu Asp Lys Pro Lys Thr Glu Lys His Asn Ala His 
  1               5                  10                  15
Gly Ala Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
             20                  25                  30
Arg Val Glu Met Glu Asp Ala His Thr Ala Val Val Gly Ile Pro His 
         35                  40                  45
Gly Leu Glu Asp Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
     50                  55                  60
Ser Arg Val Ala Asn Tyr Cys Ser Thr His Leu Leu Glu His Ile Thr 
 65                  70                  75                  80
Thr Asn Glu Asp Phe Arg Ala Ala Asp Lys Ser Gly Phe Ala Leu Glu 
                 85                  90                  95
Pro Ser Val Glu Asn Val Lys Thr Gly Ile Arg Thr Gly Phe Leu Lys 
             100                105                110
Ile Asp Glu Tyr Met Arg Asn Phe Ser Asp Leu Arg Asn Gly Met Asp 
         115                120                125
Arg Ser Gly Ser Thr Ala Val Gly Val Met Ile Ser Pro Thr His Ile 
     130                135                140
Tyr Phe Ile Asn Cys Gly Asp Ser Arg Ala Val Leu Cys Arg Asn Gly 
 145                150                155                160
Gln Val Cys Phe Ser Thr Gln Asp His Lys Pro Cys Asn Pro Met Glu 
                 165                170                175
Lys Glu Arg Ile Gln Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val 
             180                185                190
Asn Gly Ser Leu Ala Val Ser Arg Ala Leu Gly Asp Tyr Asp Tyr Lys 
         195                200                205
Cys Val Asp Gly Lys Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro 
     210                215                220
Glu Val Tyr Glu Ile Leu Arg Ala Glu Glu Asp Glu Phe Val Val Leu 
 225                230                235                240
Ala Cys Asp Gly Ile Trp Asp Val Met Ser Asn Glu Glu Leu Cys Glu 
                 245                250                255
Phe Val Asn Ser Arg Leu Glu Val Ser Asp Asp Leu Glu Asn Val Cys 
             260                265                270
Asn Trp Val Val Asp Thr Cys Leu His Lys Gly Ser Arg Asp Asn Met 
         275                280                285
Ser Ile Val Leu Val Cys Phe Ala Asn Ala Pro Lys Val Ser Asp Glu 
     290                295                300
Ala Val Lys Arg Asp Leu Glu Leu Asp Lys His Leu Glu Ser Arg Val 
 305                310                315                320
Glu Glu Ile Met Gln Lys Ser Gly Glu Glu Gly Met Pro Asp Leu Ala 
                 325                330                335
His Val Met Arg Ile Leu Ser Ala Glu Asn Ile Pro Asn Leu Pro Pro 
             340                345                350
Gly Gly Gly Leu Ala Gly Lys Arg Asn Val Ile Glu Ala Val Tyr Ser 
         355                360                365
Arg Leu Asn Pro Asn Lys Asp Asn Asp Gly Gly Ala Gly Asp Leu Glu 
     370                375                380
Asp Ser Leu Val Ala Leu 
 385                390



<210> 7736
<211> 1503
<212> DNA
<213> Rattus norvegicus
<308> S74572
<400> 7736

ctaaacatg  gtgcatttt  ggataaacc  aaaactgaa  agcacaatg  tcacggtgc  60
gggaacggt  tgcgttacg  tctgagcag  atgcaagga  ggagagtag  aatggaaga  120
gcacacact  ctgttgtgg  aattcctca  ggcttggag  actggtcgt  ttttgcagt  180
tatgatggt  atgctggat  ccgagtggc  aattactgt  caacacatc  attagaaca  240
atcactacc  atgaagact  tagggctgc  gacaaatca  gctttgctc  tgagccgtc  300
gtggaaaat  ttaagactg  tatccgaac  ggctttttg  aaattgatg  atatatgcg  360
aacttttca  acctgagga  cgggatgga  aggagcggc  ctaccgcag  gggcgtgat  420
atttcaccg  cacacatct  ctttatcaa  tgcggtgac  cgagagctg  tctatgtag  480
aatggacaa  tctgctttt  aacccagga  cacaaacct  gtaatccaa  ggaaaagga  540
cgcatccaa  atgcaggag  cagtgtaat  atacagcgt  tgaatgggt  gttagcagt  600
tctcgtgct  tgggggact  tgattacaa  tgtgttgat  gcaagggcc  cacagagca  660
cttgtttct  cagagcctg  ggtttatga  attctaaga  cagaagagg  tgaatttgt  720
gtcctggct  gtgatggga  ctgggatgt  atgagcaat  aggagctct  tgagtttgt  780
aactctagg  ttgaggtgt  agacgacct  gagaatgtg  gcaattggg  agtggacac  840
tgtttacat  agggaagtc  agataacat  agtattgtg  tagtttgct  tgcaaatgc  900
cccaaggtc  cagatgaag  cgtgaaaag  gatttagag  tggacaagc  cttggaatc  960
cgggtggaa  aaatcatgc  gaagtctgg  gaggaagga  tgcctgatc  tgcccatgt  1020
atgcgcatt  tgtctgcag  aaatatccc  aatttacct  ccgggggag  cctcgctgg  1080
aagcgcaat  ttattgaag  tgtttatag  agacttaat  caaacaaag  caatgatgg  1140
ttttaccaa  cttcaactc  atacagtga  aatgtttcc  attatgaat  gcagacttg  1200
gcacgtcta  ttgtaaagc  agctgagaa  tctggtgac  cagcagagg  tgatcaacc  1260
accaagagc  cggaagtac  aagaagaac  aaagttttg  tttgttttt  taaactcga  1320
agaaaaaaa  aagtccagc  ttacgtcag  gcggtatct  ttcgctgtg  gcggtaacc  1380
tctagccca  cagcgaagg  ggaggagag  tcccacctt  ccttacaaa  cttgctttt  1440
catgttcat  caataaaca  gtttggctt  ttggtaaaa  accgaattg  gctgcagga  1500
ttc  1503



<210> 7737
<211> 390
<212> PRT
<213> Rattus norvegicus
<308> AAB33430
<400> 7737

Met Gly Ala Phe Leu Asp Lys Pro Lys Thr Glu Lys His Asn Ala His 
  1               5                  10                  15
Gly Ala Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
             20                  25                  30
Arg Val Glu Met Glu Asp Ala His Thr Ala Val Val Gly Ile Pro His 
         35                  40                  45
Gly Leu Glu Asp Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
     50                  55                  60
Ser Arg Val Ala Asn Tyr Cys Ser Thr His Leu Leu Glu His Ile Thr 
 65                  70                  75                  80
Thr Asn Glu Asp Phe Arg Ala Ala Asp Lys Ser Gly Phe Ala Leu Glu 
                 85                  90                  95
Pro Ser Val Glu Asn Val Lys Thr Gly Ile Arg Thr Gly Phe Leu Lys 
             100                105                110
Ile Asp Glu Tyr Met Arg Asn Phe Ser Asp Leu Arg Asn Gly Met Asp 
         115                120                125
Arg Ser Gly Ser Thr Ala Val Gly Val Met Ile Ser Pro Thr His Ile 
     130                135                140
Tyr Phe Ile Asn Cys Gly Asp Ser Arg Ala Val Leu Cys Arg Asn Gly 
 145                150                155                160
Gln Val Cys Phe Ser Thr Gln Asp His Lys Pro Cys Asn Pro Met Glu 
                 165                170                175
Lys Glu Arg Ile Gln Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val 
             180                185                190
Asn Gly Ser Leu Ala Val Ser Arg Ala Leu Gly Asp Tyr Asp Tyr Lys 
         195                200                205
Cys Val Asp Gly Lys Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro 
     210                215                220
Glu Val Tyr Glu Ile Leu Arg Ala Glu Glu Asp Glu Phe Val Val Leu 
 225                230                235                240
Ala Cys Asp Gly Ile Trp Asp Val Met Ser Asn Glu Glu Leu Cys Glu 
                 245                250                255
Phe Val Asn Ser Arg Leu Glu Val Ser Asp Asp Leu Glu Asn Val Cys 
             260                265                270
Asn Trp Val Val Asp Thr Cys Leu His Lys Gly Ser Arg Asp Asn Met 
         275                280                285
Ser Ile Val Leu Val Cys Phe Ala Asn Ala Pro Lys Val Ser Asp Glu 
     290                295                300
Ala Val Lys Arg Asp Leu Glu Leu Asp Lys His Leu Glu Ser Arg Val 
 305                310                315                320
Glu Glu Ile Met Gln Lys Ser Gly Glu Glu Gly Met Pro Asp Leu Ala 
                 325                330                335
His Val Met Arg Ile Leu Ser Ala Glu Asn Ile Pro Asn Leu Pro Pro 
             340                345                350
Gly Gly Gly Leu Ala Gly Lys Arg Asn Val Ile Glu Ala Val Tyr Ser 
         355                360                365
Arg Leu Asn Pro Asn Lys Asp Asn Asp Gly Gly Ala Gly Asp Leu Glu 
     370                375                380
Asp Ser Leu Val Ala Leu 
 385                390



<210> 7739
<211> 976
<212> PRT
<213> Rattus norvegicus
<308> AAB32731
<400> 7739

Met Lys Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg 
  1               5                  10                  15
Trp Ile Gly Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Gln 
             20                  25                  30
Lys Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys 
         35                  40                  45
Ser Ser Gly Asp Thr Asp Glu Val Leu Lys Leu Leu His Arg Gly Ala 
     50                  55                  60
Asp Ile Asn Tyr Ala Asn Val Asp Gly Leu Thr Ala Leu His Gln Ala 
 65                  70                  75                  80
Cys Ile Asp Asp Asn Val Asp Met Val Lys Phe Leu Val Glu Asn Gly 
                 85                  90                  95
Ala Asn Ile Asn Gln Pro Asp Asn Glu Gly Trp Ile Pro Leu His Ala 
             100                105                110
Ala Ala Ser Cys Gly Tyr Leu Asp Ile Ala Glu Phe Leu Ile Gly Gln 
         115                120                125
Gly Ala His Val Gly Ala Val Asn Ser Glu Gly Asp Thr Pro Leu Asp 
     130                135                140
Ile Ala Glu Glu Glu Ala Met Glu Glu Leu Leu Gln Asn Glu Val Asn 
 145                150                155                160
Arg Gln Gly Val Asp Ile Glu Ala Ala Arg Lys Glu Glu Glu Arg Ile 
                 165                170                175
Met Leu Arg Asp Ala Arg Gln Trp Leu Asn Ser Gly His Ile Ser Asp 
             180                185                190
Val Arg His Ala Lys Ser Gly Gly Thr Ala Leu His Val Ala Ala Ala 
         195                200                205
Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu Ile Gln Ala Gly Tyr Asp 
     210                215                220
Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr Pro Leu His Ala Ala Ala 
 225                230                235                240
His Trp Gly Lys Glu Glu Ala Cys Arg Ile Leu Val Asp Asn Leu Cys 
                 245                250                255
Asp Met Glu Thr Val Asn Lys Val Gly Gln Thr Ala Phe Asp Val Ala 
             260                265                270
Asp Glu Asp Ile Leu Gly Tyr Leu Glu Glu Leu Gln Lys Lys Gln Asn 
         275                280                285
Leu Leu His Ser Glu Lys Arg Asp Lys Lys Ser Pro Leu Ile Glu Ser 
     290                295                300
Thr Ala Asn Met Glu Asn Asn Gln Pro Gln Lys Thr Phe Lys Asn Lys 
 305                310                315                320
Glu Thr Leu Ile Ile Glu Pro Glu Lys Asn Ala Ser Arg Ile Glu Ser 
                 325                330                335
Leu Glu Gln Glu Lys Ala Asp Glu Glu Glu Glu Gly Lys Lys Asp Glu 
             340                345                350
Ser Ser Cys Ser Ser Glu Glu Asp Glu Glu Asp Asp Ser Glu Ser Glu 
         355                360                365
Ala Glu Thr Asp Lys Thr Lys Pro Met Ala Ser Val Thr Asn Ala His 
     370                375                380
Thr Ala Ser Thr Gln Ala Ala Pro Ala Ala Val Thr Thr Pro Thr Leu 
 385                390                395                400
Ser Ser Asn Gln Gly Thr Pro Thr Ser Pro Val Lys Lys Phe Pro Thr 
                 405                410                415
Ser Thr Thr Lys Ile Ser Pro Lys Glu Glu Glu Arg Lys Asp Glu Ser 
             420                425                430
Pro Ala Ser Trp Arg Leu Gly Leu Arg Lys Thr Gly Ser Tyr Gly Ala 
         435                440                445
Leu Ala Glu Ile Thr Ala Ser Lys Glu Ala Gln Lys Glu Lys Asp Thr 
     450                455                460
Ala Gly Val Ile Arg Ser Ala Ser Ser Pro Arg Leu Ser Ser Ser Leu 
 465                470                475                480
Asp Asn Lys Glu Lys Glu Lys Asp Asn Lys Gly Thr Arg Leu Ala Tyr 
                 485                490                495
Val Ala Pro Thr Ile Pro Arg Arg Leu Gly Ser Thr Ser Asp Ile Glu 
             500                505                510
Glu Lys Glu Asn Arg Glu Ser Ser Asn Leu Arg Thr Ser Ser Ser Tyr 
         515                520                525
Thr Arg Arg Lys Trp Glu Asp Asp Leu Lys Lys Asn Ser Ser Ile Asn 
     530                535                540
Glu Gly Ser Thr Tyr His Arg Ser Thr Ser Asn Arg Leu Trp Ala Glu 
 545                550                555                560
Asp Ser Thr Glu Lys Glu Lys Asp Ser Ala Pro Thr Ala Ala Thr Ile 
                 565                570                575
Leu Val Ala Pro Thr Val Val Ser Ala Ala Ala Ser Ser Thr Thr Ala 
             580                585                590
Leu Thr Thr Thr Thr Ala Gly Thr Leu Ser Ser Thr Ser Glu Val Arg 
         595                600                605
Glu Arg Arg Arg Ser Tyr Leu Thr Pro Val Arg Asp Glu Glu Ser Glu 
     610                615                620
Ser Gln Arg Lys Ala Arg Ser Arg Gln Ala Arg Gln Ser Arg Arg Ser 
 625                630                635                640
Thr Gln Gly Val Thr Leu Thr Asp Leu Gln Glu Ala Glu Lys Thr Ile 
                 645                650                655
Gly Arg Ser Arg Ser Thr Arg Thr Arg Glu Gln Glu Asn Glu Glu Lys 
             660                665                670
Asp Lys Glu Glu Lys Glu Lys Gln Asp Lys Glu Lys Gln Glu Glu Lys 
         675                680                685
Lys Glu Ser Glu Val Ser Arg Glu Asp Glu Tyr Lys Gln Lys Tyr Ser 
     690                695                700
Arg Thr Tyr Asp Glu Thr Tyr Ala Arg Tyr Arg Pro Val Ser Thr Ser 
 705                710                715                720
Ser Ser Ser Thr Pro Ser Ser Ser Ser Leu Ser Thr Leu Gly Ser Ser 
                 725                730                735
Leu Tyr Ala Ser Ser Gln Leu Asn Arg Pro Asn Ser Leu Val Gly Ile 
             740                745                750
Thr Ser Ala Tyr Ser Arg Gly Leu Thr Lys Asp Asn Glu Arg Glu Gly 
         755                760                765
Glu Lys Lys Glu Glu Glu Lys Glu Gly Glu Asp Lys Ser Gln Pro Lys 
     770                775                780
Ser Ile Arg Glu Arg Arg Arg Pro Arg Glu Lys Arg Arg Ser Thr Gly 
 785                790                795                800
Val Ser Phe Trp Thr Gln Asp Ser Asp Glu Asn Glu Gln Glu Arg Gln 
                 805                810                815
Ser Asp Thr Glu Asp Gly Ser Ser Lys Arg Asp Thr Gln Thr Asp Ser 
             820                825                830
Val Ser Arg Tyr Asp Ser Ser Ser Thr Ser Ser Ser Asp Arg Tyr Asp 
         835                840                845
Ser Leu Leu Gly Arg Ser Ala Ser Tyr Ser Tyr Leu Glu Glu Arg Lys 
     850                855                860
Pro Tyr Gly Ser Arg Leu Glu Lys Asp Asp Ser Thr Asp Phe Lys Lys 
 865                870                875                880
Leu Tyr Glu Gln Ile Leu Ala Glu Asn Glu Lys Leu Lys Ala Gln Leu 
                 885                890                895
His Asp Thr Asn Met Glu Leu Thr Asp Leu Lys Leu Gln Leu Glu Lys 
             900                905                910
Ala Thr Gln Arg Gln Glu Arg Phe Ala Asp Arg Ser Leu Leu Glu Met 
         915                920                925
Glu Lys Arg Glu Arg Arg Ala Leu Glu Arg Arg Ile Ser Glu Met Glu 
     930                935                940
Glu Glu Leu Lys Met Leu Pro Asp Leu Lys Ala Asp Asn Gln Arg Leu 
 945                950                955                960
Lys Asp Glu Asn Gly Ala Leu Ile Arg Val Ile Ser Lys Leu Ser Lys 
                 965                970                975



<210> 7740
<211> 4616
<212> DNA
<213> Homo sapiens
<308> XM_006578
<400> 7740

atgaagatg  cggacgcga  gcagaagcg  aacgagcag  tgaaacgct  gatcggctc  3360
gagacggac  tcgagcctc  ggtggtgaa  cgccagaag  ccaaggtga  gttcgacga  3420
ggcgccgtc  tcctggctg  ttgctccag  ggcgacacg  acgaggtcc  caagctgct  3480
caccgcggc  ccgacatca  ttacgccaa  gtggacgga  tcactgccc  gcaccaggc  3540
tgcattgat  acaatgttg  tatggtgaa  tttctggta  aaaatggag  aaatattaa  3600
caacctgat  atgaaggct  gataccact  catgcagca  cttcctgtg  atatcttga  3660
attgcagag  ttttgattg  tcaaggagc  catgtaggg  ctgtcaaca  tgaaggaga  3720
acaccttta  atattgcgg  ggaggaggc  atggaagag  tacttcaaa  tgaagttaa  3780
cggcaaggg  ttgatatag  agcagctcg  aaggaagaa  aacggatca  gcttagaga  3840
gccaggcag  ggctaaata  tggtcatat  aatgatgtc  ggcatgcaa  atctggagg  3900
acagcactt  acgttgcag  tgctaaagg  tatacggaa  ttttaaaac  tttaataca  3960
gcaggctat  atgttaata  taaagacta  gatggctgg  cacctcttc  tgctgcagc  4020
cattggggt  aagaagaag  atgtcgaat  ttagtggac  atctgtgtg  tatggagat  4080
gtcaacaaa  tgggccaaa  agcctttga  gtagcagat  aagacattt  aggatattt  4140
gaagagttg  aaaagaaac  aaatctgct  catagtgaa  aacgggaca  gaaatctcc  4200
ctaattgaa  caacagcaa  tatggacaa  aatcagtca  agaagacct  taaaaacaa  4260
gagacgttg  ttattgaac  agagaaaaa  gcatcccgt  ttgaatctc  ggaacaaga  4320
aaggttgat  aagaagaag  aggaaagaa  gatgagtct  gctgctcta  tgaagaaga  4380
gaggaagat  actcggaat  agaagctga  acagataag  caaaacccc  ggcttctgt  4440
actaatgcc  acacttcta  tacacaagc  gctcctgta  ctgttacaa  acctactgt  4500
tcatcaggt  aagcaacac  tacatcacc  attaaaaag  ttccaacca  agctacaaa  4560
atttctccc  aagaagaag  gagaaaaga  gagtctcct  caacttgga  gttagg  4616



<210> 7741
<211> 1030
<212> PRT
<213> Homo sapiens
<308> XP_006578
<400> 7741

Met Lys Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg 
  1               5                  10                  15
Trp Ile Gly Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Gln 
             20                  25                  30
Lys Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys 
         35                  40                  45
Ser Ser Gly Asp Thr Asp Glu Val Leu Lys Leu Leu His Arg Gly Ala 
     50                  55                  60
Asp Ile Asn Tyr Ala Asn Val Asp Gly Leu Thr Ala Leu His Gln Ala 
 65                  70                  75                  80
Cys Ile Asp Asp Asn Val Asp Met Val Lys Phe Leu Val Glu Asn Gly 
                 85                  90                  95
Ala Asn Ile Asn Gln Pro Asp Asn Glu Gly Trp Ile Pro Leu His Ala 
             100                105                110
Ala Ala Ser Cys Gly Tyr Leu Asp Ile Ala Glu Phe Leu Ile Gly Gln 
         115                120                125
Gly Ala His Val Gly Ala Val Asn Ser Glu Gly Asp Thr Pro Leu Asp 
     130                135                140
Ile Ala Glu Glu Glu Ala Met Glu Glu Leu Leu Gln Asn Glu Val Asn 
 145                150                155                160
Arg Gln Gly Val Asp Ile Glu Ala Ala Arg Lys Glu Glu Glu Arg Ile 
                 165                170                175
Met Leu Arg Asp Ala Arg Gln Trp Leu Asn Ser Gly His Ile Asn Asp 
             180                185                190
Val Arg His Ala Lys Ser Gly Gly Thr Ala Leu His Val Ala Ala Ala 
         195                200                205
Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu Ile Gln Ala Gly Tyr Asp 
     210                215                220
Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr Pro Leu His Ala Ala Ala 
 225                230                235                240
His Trp Gly Lys Glu Glu Ala Cys Arg Ile Leu Val Asp Asn Leu Cys 
                 245                250                255
Asp Met Glu Met Val Asn Lys Val Gly Gln Thr Ala Phe Asp Val Ala 
             260                265                270
Asp Glu Asp Ile Leu Gly Tyr Leu Glu Glu Leu Gln Lys Lys Gln Asn 
         275                280                285
Leu Leu His Ser Glu Lys Arg Asp Lys Lys Ser Pro Leu Ile Glu Ser 
     290                295                300
Thr Ala Asn Met Asp Asn Asn Gln Ser Gln Lys Thr Phe Lys Asn Lys 
 305                310                315                320
Glu Thr Leu Ile Ile Glu Pro Glu Lys Asn Ala Ser Arg Ile Glu Ser 
                 325                330                335
Leu Glu Gln Glu Lys Val Asp Glu Glu Glu Glu Gly Lys Lys Asp Glu 
             340                345                350
Ser Ser Cys Ser Ser Glu Glu Asp Glu Glu Asp Asp Ser Glu Ser Glu 
         355                360                365
Ala Glu Thr Asp Lys Thr Lys Pro Leu Ala Ser Val Thr Asn Ala Asn 
     370                375                380
Thr Ser Ser Thr Gln Ala Ala Pro Val Ala Val Thr Thr Pro Thr Val 
 385                390                395                400
Ser Ser Gly Gln Ala Thr Pro Thr Ser Pro Ile Lys Lys Phe Pro Thr 
                 405                410                415
Thr Ala Thr Lys Ile Ser Pro Lys Glu Glu Glu Arg Lys Asp Glu Ser 
             420                425                430
Pro Ala Thr Trp Arg Leu Gly Leu Arg Lys Thr Gly Ser Tyr Gly Ala 
         435                440                445
Leu Ala Glu Ile Thr Ala Ser Lys Glu Gly Gln Lys Glu Lys Asp Thr 
     450                455                460
Ala Gly Val Thr Arg Ser Ala Ser Ser Pro Arg Leu Ser Ser Ser Leu 
 465                470                475                480
Asp Asn Lys Glu Lys Glu Lys Asp Ser Lys Gly Thr Arg Leu Ala Tyr 
                 485                490                495
Val Ala Pro Thr Ile Pro Arg Arg Leu Ala Ser Thr Ser Asp Ile Glu 
             500                505                510
Glu Lys Glu Asn Arg Asp Ser Ser Ser Leu Arg Thr Ser Ser Ser Tyr 
         515                520                525
Thr Arg Arg Lys Trp Glu Asp Asp Leu Lys Lys Asn Ser Ser Val Asn 
     530                535                540
Glu Gly Ser Thr Tyr His Lys Ser Cys Ser Phe Gly Arg Arg Gln Asp 
 545                550                555                560
Asp Leu Ile Ser Ser Ser Val Pro Ser Thr Thr Ser Thr Pro Thr Val 
                 565                570                575
Thr Ser Ala Ala Gly Leu Gln Lys Ser Leu Leu Ser Ser Thr Ser Thr 
             580                585                590
Thr Thr Lys Ile Thr Thr Gly Ser Ser Ser Ala Gly Thr Gln Ser Ser 
         595                600                605
Thr Ser Asn Arg Leu Trp Ala Glu Asp Ser Thr Glu Lys Glu Lys Asp 
     610                615                620
Ser Val Pro Thr Ala Val Thr Ile Pro Val Ala Pro Thr Val Val Asn 
 625                630                635                640
Ala Ala Ala Ser Thr Thr Thr Leu Thr Thr Thr Thr Ala Gly Thr Val 
                 645                650                655
Ser Ser Thr Thr Glu Val Arg Glu Arg Arg Arg Ser Tyr Leu Thr Pro 
             660                665                670
Val Arg Asp Glu Glu Ser Glu Ser Gln Arg Lys Ala Arg Ser Arg Gln 
         675                680                685
Ala Arg Gln Ser Arg Arg Ser Thr Gln Gly Val Thr Leu Thr Asp Leu 
     690                695                700
Gln Glu Ala Glu Lys Thr Ile Gly Arg Ser Arg Ser Thr Arg Thr Arg 
 705                710                715                720
Glu Gln Glu Asn Glu Glu Lys Glu Lys Glu Glu Lys Glu Lys Gln Asp 
                 725                730                735
Lys Glu Lys Gln Glu Glu Lys Lys Glu Ser Glu Thr Ser Arg Glu Asp 
             740                745                750
Glu Tyr Lys Gln Lys Tyr Ser Arg Thr Tyr Asp Glu Thr Tyr Gln Arg 
         755                760                765
Tyr Arg Pro Val Ser Thr Ser Ser Ser Thr Thr Pro Ser Ser Ser Leu 
     770                775                780
Ser Thr Met Ser Ser Ser Leu Tyr Ala Ser Ser Gln Leu Asn Arg Pro 
 785                790                795                800
Asn Ser Leu Val Gly Ile Thr Ser Ala Tyr Ser Arg Gly Ile Thr Lys 
                 805                810                815
Glu Asn Glu Arg Glu Gly Glu Lys Arg Glu Glu Glu Lys Glu Gly Glu 
             820                825                830
Asp Lys Ser Gln Pro Lys Ser Ile Arg Glu Arg Arg Arg Pro Arg Glu 
         835                840                845
Lys Arg Arg Ser Thr Gly Val Ser Phe Trp Thr Gln Asp Ser Asp Glu 
     850                855                860
Asn Glu Gln Glu Gln Gln Ser Asp Thr Glu Glu Gly Ser Asn Lys Lys 
 865                870                875                880
Glu Thr Gln Thr Asp Ser Ile Ser Arg Tyr Glu Thr Ser Ser Thr Ser 
                 885                890                895
Ala Gly Asp Arg Tyr Asp Ser Leu Leu Gly Arg Ser Gly Ser Tyr Ser 
             900                905                910
Tyr Leu Glu Glu Arg Lys Pro Tyr Ser Ser Arg Leu Glu Lys Asp Asp 
         915                920                925
Ser Thr Asp Phe Lys Lys Leu Tyr Glu Gln Ile Leu Ala Glu Asn Glu 
     930                935                940
Lys Leu Lys Ala Gln Leu His Asp Thr Asn Met Glu Leu Thr Asp Leu 
 945                950                955                960
Lys Leu Gln Leu Glu Lys Ala Thr Gln Arg Gln Glu Arg Phe Ala Asp 
                 965                970                975
Arg Ser Leu Leu Glu Met Glu Lys Arg Glu Arg Arg Ala Leu Glu Arg 
             980                985                990
Arg Ile Ser Glu Met Glu Glu Glu Leu Lys Met Leu Pro Asp Leu Lys 
         995                1000                1005
Ala Asp Asn Gln Arg Leu Lys Asp Glu Asn Gly Ala Leu Ile Arg Val 
     1010                1015                1020
Ile Ser Lys Leu Ser Lys 
 1025                1030



<210> 7742
<211> 3167
<212> DNA
<213> Rattus norvegicus
<308> S75359
<400> 7742

gaattcatg  gatggaaac  taggtcaaa  ctgtttgga  aaattggaa  tacagtttt  60
tctagccac  tctctgaga  gtctgaaga  agcagcagg  gaaagtcat  gtcaagtga  120
tttgttctt  tgtaaggaa  cctcgttca  taaggccgt  tacttcagt  aaacagcag  180
accagtaat  aaggtggcc  ggacaggac  cgtgcgaat  ggacaatga  tcagctata  240
acttacatc  gattactgg  agcctgtct  ttcatcatt  ctcatgttc  agggcagaa  300
ctagatagt  tgctccatg  tactggtat  aaatcagac  tggaccaga  gaagccgga  360
aatggagtg  cgttagcac  agaggacac  ttacctttc  taaaatgct  ttgctcagg  420
cactgccca  atgacgcta  taataacac  tgcataact  atggccatt  ctttgccat  480
atagaagaa  atgatcagg  agaaaccac  ttaacttct  ggtgtatga  gtatgaagg  540
tctgatttt  aatgcaagg  ttcaccaaa  gcccagcta  gcaggacaa  agaatgttg  600
cggaccaat  tgtgcaacc  atatttgca  cctacactg  cccctgtcg  tataggccc  660
ttctttgat  gcagcgtcc  atggctggc  gtgctcatc  ctatggctg  ctgtattgt  720
gccatgatc  tcttctcca  ctgcttctg  tacaaacat  actgtaaga  tatctcaag  780
agaggtcgt  acaaccgtg  cttggaaca  gatgaagca  ttattccag  aggagaatc  840
ctgaaagac  tgattgacc  gtcacaaag  tctggtagt  gatctggat  acctttatt  900
gttcagcga  ctattgcca  acagattca  atggttcgg  aggttggta  aggccggta  960
ggagaagta  ggatgggta  atggcgtgg  gaaaaagtg  ctgtcaaag  attttttac  1020
actgaagaa  ctagctggt  tagagaaac  gaaatctac  agacggtgt  aatgcgtca  1080
gaaaatata  ttggtttta  agctgcaga  attaaaggc  ccggttcct  gactcagct  1140
tatttgatt  ctgattacc  tgagaatgg  tctctctat  acttcctga  atgtgccac  1200
ctggacacc  gagccctac  caagttagc  tattctgct  cctgtggtc  gtgccacct  1260
cacacagaa  tttatggca  gcaaggcaa  cctgcaatt  ctcatcgag  cctgaagag  1320
aaaaacatc  ttattaaga  aaatggtag  tgctgtatt  ctgacctgg  cctagctgt  1380
aaattcaac  gtgacacaa  tgaagttga  atacccttg  acaccaggg  gggcaccag  1440
cggtacatg  ctccagaag  gctggacga  agcctgagt  aaaaccatt  ccagcccta  1500
atcatggct  acatctaca  ctttggttt  atcatttgg  agatggccc  tcgctgtat  1560
acaggagga  tcgtggagg  atatcaatt  ccatattac  acatggtgc  tagtgaccc  1620
tcttatgaa  acatgcgtg  ggtcgtgtg  gtgaaacgc  tgcggccaa  cgtctctaa  1680
cgctggaac  gtgatgaat  tcttcgagc  gttttgaag  tgatgtcag  atgctgggc  1740
cataatcca  catccagac  cacagcttt  agaatcaag  agacgctcg  aaagatggt  1800
gaatcccag  atgtaaaga  ttgacaaac  gttttgaga  agaatttag  ctgcaagaa  1860
ttcacccga  gaagggtgg  gttagcatg  actaggatg  cggcttggt  tccagactc  1920
ctcctctac  tcttcacag  ctgctaaca  taaactttc  ggactctgc  gaatgcagg  1980
ttggagctt  agacatagg  cttcagaca  gctgttctt  gcgtatgga  agctttgtt  2040
taaatgtgg  cttttgatg  ctttttggt  tttatgaat  gcatcaaga  tccaatcct  2100
ataagaagt  tctggtcaa  ctctggtta  tcactatcc  gtccataaa  tggtgcttt  2160
tgtgaaagc  ttaaggaaa  tagtgagct  agcagagat  gagaaaggc  tatttgccc  2220
ctacagaga  aatatctgt  tgtgttctg  ctctgtaaa  agcctggac  atgatctct  2280
tgggatgct  cctggttga  gatggtgca  catgcctct  atatgcata  cagacttcc  2340
ctgctgcca  gggcttaca  gacaagaat  tgaaggttg  acaggacgg  atttgtggc  2400
agtggttta  atatgcaat  tctaatcga  attcgccaa  ctcataaaa  ccatctacc  2460
tgtaactga  gtaacttct  taccaactt  atttttagc  taatagttg  aaaggccaa  2520
ctatgtata  agtgtccat  gactcgaac  gttttcctc  agtcaccat  ttgttttcc  2580
tttggtaat  atttttgtt  tataattcc  cctatccag  attggcgct  actgtcttg  2640
accatactt  gaaagaaat  cctcttcct  gagtctgcc  tactgcatc  gatcaccat  2700
tgcatacct  tgatcaaat  ctggagtct  tgttctcgg  acctcttaa  aagggaaat  2760
gtgtatcat  tgtagtgtg  ttttatttt  aaaatcttc  tagccttta  tctagccat  2820
tttacctac  tactcattc  gtacaaaac  gctcactcg  tctcacggc  gatcctcag  2880
ggaaatgat  taaagtaga  ctgtgtacg  atttcagaa  tcatgtatt  aaaaacttc  2940
cactaacac  ttactaaga  attgtctca  atcttttat  aggatgtca  ctgattttc  3000
atgactata  atgtatctt  gctatctaa  tcttttgaa  tttggtttt  taatttctg  3060
tccctaact  gtgaagaca  agaggcaga  gtacccagt  taccacatt  acactgtac  3120
ttattaaat  aaaaaatgt  tattttaaa  aaaaaaaaa  aaaaaaa  3167



<210> 7743
<211> 532
<212> PRT
<213> Rattus norvegicus
<308> AAB33865
<400> 7743

Met Thr Gln Leu Tyr Thr Tyr Ile Arg Leu Leu Gly Ala Cys Leu Phe 
  1               5                  10                  15
Ile Ile Ser His Val Gln Gly Gln Asn Leu Asp Ser Met Leu His Gly 
             20                  25                  30
Thr Gly Met Lys Ser Asp Val Asp Gln Lys Lys Pro Glu Asn Gly Val 
         35                  40                  45
Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser 
     50                  55                  60
Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly 
 65                  70                  75                  80
His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu 
                 85                  90                  95
Thr Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp 
             100                105                110
Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn 
         115                120                125
Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile Gly 
     130                135                140
Pro Phe Phe Asp Gly Ser Val Arg Trp Leu Ala Val Leu Ile Ser Met 
 145                150                155                160
Ala Val Cys Ile Val Ala Met Ile Val Phe Ser Ser Cys Phe Cys Tyr 
                 165                170                175
Lys His Tyr Cys Lys Ser Ile Ser Ser Arg Gly Arg Tyr Asn Arg Asp 
             180                185                190
Leu Glu Gln Asp Glu Ala Phe Ile Pro Val Gly Glu Ser Leu Lys Asp 
         195                200                205
Leu Ile Asp Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu 
     210                215                220
Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val 
 225                230                235                240
Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu 
                 245                250                255
Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe 
             260                265                270
Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile 
         275                280                285
Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln 
     290                295                300
Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe 
 305                310                315                320
Leu Lys Cys Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr 
                 325                330                335
Ser Ala Ala Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr 
             340                345                350
Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile 
         355                360                365
Leu Ile Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala 
     370                375                380
Val Lys Phe Asn Ser Asp Thr Asn Glu Val Asp Ile Pro Leu Asn Thr 
 385                390                395                400
Arg Val Gly Thr Arg Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser 
                 405                410                415
Leu Ser Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser 
             420                425                430
Phe Gly Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly 
         435                440                445
Ile Val Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp 
     450                455                460
Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg 
 465                470                475                480
Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Cys Leu Arg Ala Val 
                 485                490                495
Leu Lys Leu Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu 
             500                505                510
Thr Ala Leu Arg Ile Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln 
         515                520                525
Asp Val Lys Ile 
     530



<210> 7744
<211> 2932
<212> DNA
<213> Homo sapiens
<308> NM_004329
<400> 7744

gctccgcgc  gagggctgg  ggatgcgtt  cctggggtc  ggacttatg  aaatatgca  60
cagtttaat  ctgtcttgg  attcatgag  tggaagcat  ggtcaaagc  gtttggaga  120
aatcagaag  acagtttta  ctagccaca  cttggagga  tcgtaagaa  gcagtggga  180
ttgaagtca  tgtcaagtg  ttgcgatct  ttacaagaa  atctcactg  atgatagtc  240
tttaaattg  tgaagtagc  agaccaatt  ttaaaggtg  cagtacaca  gaaacatta  300
aattgaaca  tgactcagc  atacattta  atcagatta  tgggagcct  tttgttcat  360
atttctcgt  ttcaaggac  gaatctgga  agtatgctt  atggcactg  gatgaaatc  420
gactccgac  agaaaaagt  agaaaatgg  gtaacctta  caccagagg  taccttgcc  480
tttttaaag  gctattgct  agggcactg  ccagatgat  ctattaata  cacatgcat  540
actaatgga  attgctttg  catcataga  gaagatgac  agggagaaa  cacattagc  600
tcagggtgt  tgaaatatg  aggatctga  tttcagtgc  aagattctc  aaaagccca  660
ctacgccgg  caatagaat  ttgtcggac  aatttatgt  accagtatt  gcaacccac  720
ctgccccct  ttgtcatag  tccgttttt  gatggcagc  ttcgatggc  ggttttgct  780
atttctatg  ctgtctgca  aattgctat  atcatcttc  ccagctgct  ttgttacaa  840
cattattgc  agagcatct  aagcagacg  cgttacaat  gtgatttgg  acaggatga  900
gcatttatt  cagttggag  atcactaaa  gaccttatt  accagtcac  aagttctgg  960
agtgggtct  gactacctt  attggttca  cgaactatt  ccaaacaga  tcagatggt  1020
cggcaagtt  gtaaaggcc  atatggaga  gtatggatg  gcaaatggc  tggcgaaaa  1080
gtggcggtg  aagtattct  taccactga  gaagccagc  ggtttcgag  aacagaaat  1140
taccaaact  tgctaatgc  ccatgaaaa  atacttggt  tcatagcgg  agacattaa  1200
ggtacaggt  cctggactc  gctctattt  attactgat  accatgaaa  tggatctct  1260
tatgacttc  tgaaatgtg  tacactgga  accagagcc  tgcttaaat  ggcttattc  1320
gctgcctgt  gtctgtgcc  cctgcacac  gaaatttat  gcacccaag  aaagcccgc  1380
attgctcat  gagacctaa  gagcaaaaa  atcctcatc  agaaaaatg  gagttgctg  1440
attgctgac  tgggccttg  tgttaaatt  aacagtgac  caaatgaag  tgatgtgcc  1500
ttgaatacc  gggtgggca  caaacgcta  atggctccc  aagtgctgg  cgaaagcct  1560
aacaaaaac  acttccagc  ctacatcat  gctgacatc  acagcttcg  cctaatcat  1620
tgggagatg  ctcgtcgtt  tatcacagg  gggatcgtg  aagaatacc  attgccata  1680
tacaacatg  taccgagtg  tccgtcata  gaagatatg  gtgaggttg  gtgtgtcaa  1740
cgtttgcgg  caattgtgt  taatcggtg  aacagtgat  aatgtctac  agcagtttt  1800
aagctaatg  cagaatgct  ggcccacaa  ccagcctcc  gactcacag  attgagaat  1860
aagaagacg  ttgccaaga  ggttgaatc  caagatgta  aaatctgat  gttaaacca  1920
cggaggaga  actctagac  gcaagaact  tttttaccc  tggcatggg  ggaattaga  1980
tggaataag  atgttaact  ggttctcag  ctctttctt  actacgtgt  cacaggctg  2040
taatattaa  cctttcagt  ctcttatta  gatacaagc  gggaacttc  aaacacttc  2100
ttctttata  atggacagc  ttattttaa  tgtggtttt  gatgccttt  tttaagtgg  2160
tttttatga  ctgcatcaa  acttcaatc  tgattagtg  ctccagtca  gctctgggt  2220
ctgaattgc  tgttcataa  acggtgctt  ctgtgaaag  cttaagaag  taaatgagc  2280
cagcagaga  ggagaaata  actttgcct  ttacctgag  cattcagtt  gtttgtatt  2340
tacctttgt  aaacagcct  tagatgatg  tgtgtttgg  atactgctt  ttttatgat  2400
gtttgtcct  tgtccttag  gatgtgtgt  tgtctccat  cacatgcac  ccgggattc  2460
tctgctgcc  tttgaatta  aagaaaata  tttatatgc  tgcacagga  gatattggt  2520
gccggtggt  ttgtgcttt  aaaatgcaa  atctgacca  gattcgcca  tctcataca  2580
gccatttac  ttgcaagtg  gatagcttc  ccaccagct  tatttttta  catgaaagc  2640
gatgccaag  ccaaaagaa  tttaaagca  ctgtaaatt  ggactgttt  ccttcaacc  2700
ccatttttt  tgtggttat  atttttgtc  cggaaagca  cctctccaa  gttggagct  2760
ctattgcca  gaaccatgc  tacaaagaa  gcacttctt  ttgaagtga  ttcctgcat  2820
tgatagcaa  gtaagtgcc  ataaccatg  tctatattc  ttattctca  taactttta  2880
aagggaagt  atttatatt  tgtgtataa  gtgctttat  tgcaaatca  cc  2932



<210> 7745
<211> 532
<212> PRT
<213> Homo sapiens
<308> P36894
<400> 7745

Met Thr Gln Leu Tyr Ile Tyr Ile Arg Leu Leu Gly Ala Tyr Leu Phe 
  1               5                  10                  15
Ile Ile Ser Arg Val Gln Gly Gln Asn Leu Asp Ser Met Leu His Gly 
             20                  25                  30
Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly Val 
         35                  40                  45
Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser 
     50                  55                  60
Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly 
 65                  70                  75                  80
His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu 
                 85                  90                  95
Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp 
             100                105                110
Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn 
         115                120                125
Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile Gly 
     130                135                140
Pro Phe Phe Asp Gly Ser Ile Arg Trp Leu Val Leu Leu Ile Ser Met 
 145                150                155                160
Ala Val Cys Ile Ile Ala Met Ile Ile Phe Ser Ser Cys Phe Cys Tyr 
                 165                170                175
Lys His Tyr Cys Lys Ser Ile Ser Ser Arg Arg Arg Tyr Asn Arg Asp 
             180                185                190
Leu Glu Gln Asp Glu Ala Phe Ile Pro Val Gly Glu Ser Leu Lys Asp 
         195                200                205
Leu Ile Asp Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu 
     210                215                220
Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val 
 225                230                235                240
Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu 
                 245                250                255
Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe 
             260                265                270
Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile 
         275                280                285
Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln 
     290                295                300
Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe 
 305                310                315                320
Leu Lys Cys Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr 
                 325                330                335
Ser Ala Ala Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr 
             340                345                350
Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile 
         355                360                365
Leu Ile Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala 
     370                375                380
Val Lys Phe Asn Ser Asp Thr Asn Glu Val Asp Val Pro Leu Asn Thr 
 385                390                395                400
Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser 
                 405                410                415
Leu Asn Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser 
             420                425                430
Phe Gly Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly 
         435                440                445
Ile Val Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp 
     450                455                460
Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg 
 465                470                475                480
Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Cys Leu Arg Ala Val 
                 485                490                495
Leu Lys Leu Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu 
             500                505                510
Thr Ala Leu Arg Ile Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln 
         515                520                525
Asp Val Lys Ile 
     530



<210> 7746
<211> 3167
<212> DNA
<213> Rattus norvegicus
<308> S75359
<400> 7746

gaattcatg  gatggaaac  taggtcaaa  ctgtttgga  aaattggaa  tacagtttt  60
tctagccac  tctctgaga  gtctgaaga  agcagcagg  gaaagtcat  gtcaagtga  120
tttgttctt  tgtaaggaa  cctcgttca  taaggccgt  tacttcagt  aaacagcag  180
accagtaat  aaggtggcc  ggacaggac  cgtgcgaat  ggacaatga  tcagctata  240
acttacatc  gattactgg  agcctgtct  ttcatcatt  ctcatgttc  agggcagaa  300
ctagatagt  tgctccatg  tactggtat  aaatcagac  tggaccaga  gaagccgga  360
aatggagtg  cgttagcac  agaggacac  ttacctttc  taaaatgct  ttgctcagg  420
cactgccca  atgacgcta  taataacac  tgcataact  atggccatt  ctttgccat  480
atagaagaa  atgatcagg  agaaaccac  ttaacttct  ggtgtatga  gtatgaagg  540
tctgatttt  aatgcaagg  ttcaccaaa  gcccagcta  gcaggacaa  agaatgttg  600
cggaccaat  tgtgcaacc  atatttgca  cctacactg  cccctgtcg  tataggccc  660
ttctttgat  gcagcgtcc  atggctggc  gtgctcatc  ctatggctg  ctgtattgt  720
gccatgatc  tcttctcca  ctgcttctg  tacaaacat  actgtaaga  tatctcaag  780
agaggtcgt  acaaccgtg  cttggaaca  gatgaagca  ttattccag  aggagaatc  840
ctgaaagac  tgattgacc  gtcacaaag  tctggtagt  gatctggat  acctttatt  900
gttcagcga  ctattgcca  acagattca  atggttcgg  aggttggta  aggccggta  960
ggagaagta  ggatgggta  atggcgtgg  gaaaaagtg  ctgtcaaag  attttttac  1020
actgaagaa  ctagctggt  tagagaaac  gaaatctac  agacggtgt  aatgcgtca  1080
gaaaatata  ttggtttta  agctgcaga  attaaaggc  ccggttcct  gactcagct  1140
tatttgatt  ctgattacc  tgagaatgg  tctctctat  acttcctga  atgtgccac  1200
ctggacacc  gagccctac  caagttagc  tattctgct  cctgtggtc  gtgccacct  1260
cacacagaa  tttatggca  gcaaggcaa  cctgcaatt  ctcatcgag  cctgaagag  1320
aaaaacatc  ttattaaga  aaatggtag  tgctgtatt  ctgacctgg  cctagctgt  1380
aaattcaac  gtgacacaa  tgaagttga  atacccttg  acaccaggg  gggcaccag  1440
cggtacatg  ctccagaag  gctggacga  agcctgagt  aaaaccatt  ccagcccta  1500
atcatggct  acatctaca  ctttggttt  atcatttgg  agatggccc  tcgctgtat  1560
acaggagga  tcgtggagg  atatcaatt  ccatattac  acatggtgc  tagtgaccc  1620
tcttatgaa  acatgcgtg  ggtcgtgtg  gtgaaacgc  tgcggccaa  cgtctctaa  1680
cgctggaac  gtgatgaat  tcttcgagc  gttttgaag  tgatgtcag  atgctgggc  1740
cataatcca  catccagac  cacagcttt  agaatcaag  agacgctcg  aaagatggt  1800
gaatcccag  atgtaaaga  ttgacaaac  gttttgaga  agaatttag  ctgcaagaa  1860
ttcacccga  gaagggtgg  gttagcatg  actaggatg  cggcttggt  tccagactc  1920
ctcctctac  tcttcacag  ctgctaaca  taaactttc  ggactctgc  gaatgcagg  1980
ttggagctt  agacatagg  cttcagaca  gctgttctt  gcgtatgga  agctttgtt  2040
taaatgtgg  cttttgatg  ctttttggt  tttatgaat  gcatcaaga  tccaatcct  2100
ataagaagt  tctggtcaa  ctctggtta  tcactatcc  gtccataaa  tggtgcttt  2160
tgtgaaagc  ttaaggaaa  tagtgagct  agcagagat  gagaaaggc  tatttgccc  2220
ctacagaga  aatatctgt  tgtgttctg  ctctgtaaa  agcctggac  atgatctct  2280
tgggatgct  cctggttga  gatggtgca  catgcctct  atatgcata  cagacttcc  2340
ctgctgcca  gggcttaca  gacaagaat  tgaaggttg  acaggacgg  atttgtggc  2400
agtggttta  atatgcaat  tctaatcga  attcgccaa  ctcataaaa  ccatctacc  2460
tgtaactga  gtaacttct  taccaactt  atttttagc  taatagttg  aaaggccaa  2520
ctatgtata  agtgtccat  gactcgaac  gttttcctc  agtcaccat  ttgttttcc  2580
tttggtaat  atttttgtt  tataattcc  cctatccag  attggcgct  actgtcttg  2640
accatactt  gaaagaaat  cctcttcct  gagtctgcc  tactgcatc  gatcaccat  2700
tgcatacct  tgatcaaat  ctggagtct  tgttctcgg  acctcttaa  aagggaaat  2760
gtgtatcat  tgtagtgtg  ttttatttt  aaaatcttc  tagccttta  tctagccat  2820
tttacctac  tactcattc  gtacaaaac  gctcactcg  tctcacggc  gatcctcag  2880
ggaaatgat  taaagtaga  ctgtgtacg  atttcagaa  tcatgtatt  aaaaacttc  2940
cactaacac  ttactaaga  attgtctca  atcttttat  aggatgtca  ctgattttc  3000
atgactata  atgtatctt  gctatctaa  tcttttgaa  tttggtttt  taatttctg  3060
tccctaact  gtgaagaca  agaggcaga  gtacccagt  taccacatt  acactgtac  3120
ttattaaat  aaaaaatgt  tattttaaa  aaaaaaaaa  aaaaaaa  3167



<210> 7747
<211> 532
<212> PRT
<213> Rattus norvegicus
<308> AAB33865
<400> 7747

Met Thr Gln Leu Tyr Thr Tyr Ile Arg Leu Leu Gly Ala Cys Leu Phe 
  1               5                  10                  15
Ile Ile Ser His Val Gln Gly Gln Asn Leu Asp Ser Met Leu His Gly 
             20                  25                  30
Thr Gly Met Lys Ser Asp Val Asp Gln Lys Lys Pro Glu Asn Gly Val 
         35                  40                  45
Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser 
     50                  55                  60
Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly 
 65                  70                  75                  80
His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu 
                 85                  90                  95
Thr Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp 
             100                105                110
Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn 
         115                120                125
Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile Gly 
     130                135                140
Pro Phe Phe Asp Gly Ser Val Arg Trp Leu Ala Val Leu Ile Ser Met 
 145                150                155                160
Ala Val Cys Ile Val Ala Met Ile Val Phe Ser Ser Cys Phe Cys Tyr 
                 165                170                175
Lys His Tyr Cys Lys Ser Ile Ser Ser Arg Gly Arg Tyr Asn Arg Asp 
             180                185                190
Leu Glu Gln Asp Glu Ala Phe Ile Pro Val Gly Glu Ser Leu Lys Asp 
         195                200                205
Leu Ile Asp Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu 
     210                215                220
Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val 
 225                230                235                240
Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu 
                 245                250                255
Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe 
             260                265                270
Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile 
         275                280                285
Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln 
     290                295                300
Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe 
 305                310                315                320
Leu Lys Cys Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr 
                 325                330                335
Ser Ala Ala Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr 
             340                345                350
Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile 
         355                360                365
Leu Ile Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala 
     370                375                380
Val Lys Phe Asn Ser Asp Thr Asn Glu Val Asp Ile Pro Leu Asn Thr 
 385                390                395                400
Arg Val Gly Thr Arg Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser 
                 405                410                415
Leu Ser Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser 
             420                425                430
Phe Gly Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly 
         435                440                445
Ile Val Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp 
     450                455                460
Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg 
 465                470                475                480
Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Cys Leu Arg Ala Val 
                 485                490                495
Leu Lys Leu Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu 
             500                505                510
Thr Ala Leu Arg Ile Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln 
         515                520                525
Asp Val Lys Ile 
     530



<210> 7748
<211> 2932
<212> DNA
<213> Homo sapiens
<308> NM_004329
<400> 7748

gctccgcgc  gagggctgg  ggatgcgtt  cctggggtc  ggacttatg  aaatatgca  60
cagtttaat  ctgtcttgg  attcatgag  tggaagcat  ggtcaaagc  gtttggaga  120
aatcagaag  acagtttta  ctagccaca  cttggagga  tcgtaagaa  gcagtggga  180
ttgaagtca  tgtcaagtg  ttgcgatct  ttacaagaa  atctcactg  atgatagtc  240
tttaaattg  tgaagtagc  agaccaatt  ttaaaggtg  cagtacaca  gaaacatta  300
aattgaaca  tgactcagc  atacattta  atcagatta  tgggagcct  tttgttcat  360
atttctcgt  ttcaaggac  gaatctgga  agtatgctt  atggcactg  gatgaaatc  420
gactccgac  agaaaaagt  agaaaatgg  gtaacctta  caccagagg  taccttgcc  480
tttttaaag  gctattgct  agggcactg  ccagatgat  ctattaata  cacatgcat  540
actaatgga  attgctttg  catcataga  gaagatgac  agggagaaa  cacattagc  600
tcagggtgt  tgaaatatg  aggatctga  tttcagtgc  aagattctc  aaaagccca  660
ctacgccgg  caatagaat  ttgtcggac  aatttatgt  accagtatt  gcaacccac  720
ctgccccct  ttgtcatag  tccgttttt  gatggcagc  ttcgatggc  ggttttgct  780
atttctatg  ctgtctgca  aattgctat  atcatcttc  ccagctgct  ttgttacaa  840
cattattgc  agagcatct  aagcagacg  cgttacaat  gtgatttgg  acaggatga  900
gcatttatt  cagttggag  atcactaaa  gaccttatt  accagtcac  aagttctgg  960
agtgggtct  gactacctt  attggttca  cgaactatt  ccaaacaga  tcagatggt  1020
cggcaagtt  gtaaaggcc  atatggaga  gtatggatg  gcaaatggc  tggcgaaaa  1080
gtggcggtg  aagtattct  taccactga  gaagccagc  ggtttcgag  aacagaaat  1140
taccaaact  tgctaatgc  ccatgaaaa  atacttggt  tcatagcgg  agacattaa  1200
ggtacaggt  cctggactc  gctctattt  attactgat  accatgaaa  tggatctct  1260
tatgacttc  tgaaatgtg  tacactgga  accagagcc  tgcttaaat  ggcttattc  1320
gctgcctgt  gtctgtgcc  cctgcacac  gaaatttat  gcacccaag  aaagcccgc  1380
attgctcat  gagacctaa  gagcaaaaa  atcctcatc  agaaaaatg  gagttgctg  1440
attgctgac  tgggccttg  tgttaaatt  aacagtgac  caaatgaag  tgatgtgcc  1500
ttgaatacc  gggtgggca  caaacgcta  atggctccc  aagtgctgg  cgaaagcct  1560
aacaaaaac  acttccagc  ctacatcat  gctgacatc  acagcttcg  cctaatcat  1620
tgggagatg  ctcgtcgtt  tatcacagg  gggatcgtg  aagaatacc  attgccata  1680
tacaacatg  taccgagtg  tccgtcata  gaagatatg  gtgaggttg  gtgtgtcaa  1740
cgtttgcgg  caattgtgt  taatcggtg  aacagtgat  aatgtctac  agcagtttt  1800
aagctaatg  cagaatgct  ggcccacaa  ccagcctcc  gactcacag  attgagaat  1860
aagaagacg  ttgccaaga  ggttgaatc  caagatgta  aaatctgat  gttaaacca  1920
cggaggaga  actctagac  gcaagaact  tttttaccc  tggcatggg  ggaattaga  1980
tggaataag  atgttaact  ggttctcag  ctctttctt  actacgtgt  cacaggctg  2040
taatattaa  cctttcagt  ctcttatta  gatacaagc  gggaacttc  aaacacttc  2100
ttctttata  atggacagc  ttattttaa  tgtggtttt  gatgccttt  tttaagtgg  2160
tttttatga  ctgcatcaa  acttcaatc  tgattagtg  ctccagtca  gctctgggt  2220
ctgaattgc  tgttcataa  acggtgctt  ctgtgaaag  cttaagaag  taaatgagc  2280
cagcagaga  ggagaaata  actttgcct  ttacctgag  cattcagtt  gtttgtatt  2340
tacctttgt  aaacagcct  tagatgatg  tgtgtttgg  atactgctt  ttttatgat  2400
gtttgtcct  tgtccttag  gatgtgtgt  tgtctccat  cacatgcac  ccgggattc  2460
tctgctgcc  tttgaatta  aagaaaata  tttatatgc  tgcacagga  gatattggt  2520
gccggtggt  ttgtgcttt  aaaatgcaa  atctgacca  gattcgcca  tctcataca  2580
gccatttac  ttgcaagtg  gatagcttc  ccaccagct  tatttttta  catgaaagc  2640
gatgccaag  ccaaaagaa  tttaaagca  ctgtaaatt  ggactgttt  ccttcaacc  2700
ccatttttt  tgtggttat  atttttgtc  cggaaagca  cctctccaa  gttggagct  2760
ctattgcca  gaaccatgc  tacaaagaa  gcacttctt  ttgaagtga  ttcctgcat  2820
tgatagcaa  gtaagtgcc  ataaccatg  tctatattc  ttattctca  taactttta  2880
aagggaagt  atttatatt  tgtgtataa  gtgctttat  tgcaaatca  cc  2932



<210> 7749
<211> 532
<212> PRT
<213> Homo sapiens
<308> P36894
<400> 7749

Met Thr Gln Leu Tyr Ile Tyr Ile Arg Leu Leu Gly Ala Tyr Leu Phe 
  1               5                  10                  15
Ile Ile Ser Arg Val Gln Gly Gln Asn Leu Asp Ser Met Leu His Gly 
             20                  25                  30
Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly Val 
         35                  40                  45
Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser 
     50                  55                  60
Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly 
 65                  70                  75                  80
His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu 
                 85                  90                  95
Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp 
             100                105                110
Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn 
         115                120                125
Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile Gly 
     130                135                140
Pro Phe Phe Asp Gly Ser Ile Arg Trp Leu Val Leu Leu Ile Ser Met 
 145                150                155                160
Ala Val Cys Ile Ile Ala Met Ile Ile Phe Ser Ser Cys Phe Cys Tyr 
                 165                170                175
Lys His Tyr Cys Lys Ser Ile Ser Ser Arg Arg Arg Tyr Asn Arg Asp 
             180                185                190
Leu Glu Gln Asp Glu Ala Phe Ile Pro Val Gly Glu Ser Leu Lys Asp 
         195                200                205
Leu Ile Asp Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu 
     210                215                220
Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val 
 225                230                235                240
Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu 
                 245                250                255
Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe 
             260                265                270
Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile 
         275                280                285
Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln 
     290                295                300
Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe 
 305                310                315                320
Leu Lys Cys Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr 
                 325                330                335
Ser Ala Ala Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr 
             340                345                350
Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile 
         355                360                365
Leu Ile Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala 
     370                375                380
Val Lys Phe Asn Ser Asp Thr Asn Glu Val Asp Val Pro Leu Asn Thr 
 385                390                395                400
Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser 
                 405                410                415
Leu Asn Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser 
             420                425                430
Phe Gly Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly 
         435                440                445
Ile Val Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp 
     450                455                460
Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg 
 465                470                475                480
Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Cys Leu Arg Ala Val 
                 485                490                495
Leu Lys Leu Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu 
             500                505                510
Thr Ala Leu Arg Ile Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln 
         515                520                525
Asp Val Lys Ile 
     530



<210> 7750
<211> 1483
<212> DNA
<213> Rattus norvegicus
<308> S75435
<400> 7750

ggaagaaca  ccacaactt  cgacactga  ctgaccaac  tgtgttggc  aggaaactc  60
gaaccgctc  taactacag  agaccatga  gaaccctgg  tcacaagcc  tctttcctt  120
acatcttcc  tggaaagcc  gcctggcag  tgggaatcc  ctcctgaaa  tagtcatat  180
ttcatgcct  ttgaccttt  gacgtggga  gttggagca  cctgaaata  caatatcca  240
agccagaga  gagactgct  aaatatcct  taaaggttt  gttgaaagc  ttcaaagtg  300
agccataca  tggtaccgg  agaaaccaa  ccaaggttt  gagtttcta  tatatgtcc  360
cgcaactcc  actgagact  tcttaaata  gaagtacaa  aaaatgaag  caagtaaaa  420
ttctagtgc  tctacgtcg  tattgacaa  atattcctt  gaggaagaa  acgaagcta  480
ctactactg  tcctacggc  atagctcgg  ctggagcaa  gtatttgca  aaggaacta  540
actcatagt  gttcctgct  acaaaagct  taatgcaga  atttccccc  agcccacca  600
ttttcttcc  tcttctgct  aaacaaatc  ccacaagac  gggacatac  tttgcctcc  660
tgaaaagtt  ttccccgat  tcataaggg  gtattggaa  gaaaaggac  gcaatacga  720
cctggactc  caggaaggg  agacgctga  gactaacga  acatacatg  agtttagct  780
gcttactgt  cctgaaggg  caatgggta  agagcacag  tgtattgtc  aacacgaga  840
caacaaagg  ggagcagac  aagagattt  ctttccttc  ataaagaaa  ttgctctga  900
tacccagcc  acaacttgc  ggcaagata  aaacgatgt  ctgcagctc  agttcacgg  960
cacctctgc  tactatact  acctgctcc  gctcctcaa  agcgtgctc  acttggcca  1020
catcagctt  tttctgctt  gaagaacag  ttcctgtgg  aataagaag  gatcctaag  1080
aaataaacg  tggaccagc  agtccattg  ttttcatcc  tactgtcat  aaggtgact  1140
atgggggtc  agctgcctt  tcttgctgg  tttgacttc  gtaaagtca  atgcacagc  1200
ttctgttat  gtgcaaaca  ttttctcac  tttgtaagc  atttcagca  cttctctct  1260
actgagctc  ccttcctga  tccatcctc  ccagcagtc  cctccccca  aagcccaaa  1320
tatcaaagc  ctggtacgc  taggctgca  gatttccct  gttgctctt  aaccagtca  1380
ctctctgaa  gcctccgct  tagacaacc  gaagagcct  ctttattgt  ggattctgt  1440
ccttgtatt  catattaga  acaataaat  ttttttaaa  atc  1483



<210> 7751
<211> 331
<212> PRT
<213> Rattus norvegicus
<308> S75435
<400> 7751

Met Lys Asn Pro Gly Ser Gln Ala Leu Phe Pro Leu His Leu Pro Trp 
  1               5                  10                  15
Lys Ala Ser Leu Ala Asp Gly Asn Pro Leu Leu Lys Val Val Ile Phe 
             20                  25                  30
Ser Cys Leu Leu Thr Phe Gly Arg Gly Lys Leu Glu Gln Pro Glu Ile 
         35                  40                  45
Ser Ile Ser Arg Ala Arg Asp Glu Thr Ala Glu Ile Ser Cys Lys Gly 
     50                  55                  60
Phe Val Glu Ser Phe Gln Ser Val Ala Ile His Trp Tyr Arg Gln Lys 
 65                  70                  75                  80
Pro Asn Gln Gly Leu Glu Phe Leu Leu Tyr Val Leu Ala Thr Pro Thr 
                 85                  90                  95
Glu Thr Phe Leu Asn Lys Lys Tyr Lys Lys Met Lys Ala Ser Lys Asn 
             100                105                110
Ser Ser Ala Ser Thr Ser Ile Leu Thr Ile Tyr Ser Leu Glu Glu Glu 
         115                120                125
Asp Glu Ala Ile Tyr Tyr Cys Ser Tyr Gly Tyr Ser Ser Gly Trp Ser 
     130                135                140
Lys Val Phe Ala Glu Gly Thr Lys Leu Ile Val Val Pro Ala Asp Lys 
 145                150                155                160
Ser Phe Asn Ala Asp Ile Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser 
                 165                170                175
Ser Ala Glu Thr Asn Leu His Lys Thr Gly Thr Tyr Leu Cys Leu Leu 
             180                185                190
Glu Lys Phe Phe Pro Asp Val Ile Arg Val Tyr Trp Lys Glu Lys Asp 
         195                200                205
Ser Asn Thr Ile Leu Asp Ser Gln Glu Gly Glu Thr Leu Lys Thr Asn 
     210                215                220
Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Gly Ser Met 
 225                230                235                240
Gly Lys Glu His Arg Cys Ile Val Lys His Glu Asn Asn Lys Gly Gly 
                 245                250                255
Ala Asp Gln Glu Ile Phe Phe Pro Ser Ile Lys Lys Val Ala Leu Ser 
             260                265                270
Thr Gln Pro Thr Thr Cys Trp Gln Asp Lys Asn Asp Val Leu Gln Leu 
         275                280                285
Gln Phe Thr Gly Thr Ser Ala Tyr Tyr Thr Tyr Leu Leu Leu Leu Leu 
     290                295                300
Lys Ser Val Leu Tyr Leu Ala Ile Ile Ser Phe Phe Leu Leu Arg Arg 
 305                310                315                320
Thr Ala Ser Cys Gly Asn Lys Lys Arg Ser Ter 
                 325                330



<210> 7752
<211> 1530
<212> DNA
<213> Homo sapiens
<308> M16768
<400> 7752

gtgaggaca  cgctttaca  cgatgcagg  ggccccatg  caccctcac  catgggaag  60
ttgacttgg  ggactcagc  aagccacag  ggtctaacg  ttctctgcg  tgatttcag  120
ctgccctgg  agaaagcac  gtgcctgca  acatgctgt  actgctcca  gcatcaacg  180
tggcagtcc  tggggctct  tgtgtatat  gtgcaggtc  cctagagca  cctcaaatt  240
ccagtacta  aacgctgtc  aaaacagcc  gcctggaat  tgtggtgtc  ggaataaca  300
tttctgcaa  atctgtata  tggtatcga  agagacctg  tgaagtcat  cagttcctg  360
tgtccattt  atatgacgg  actgtcaga  aggaatccg  cattccgtc  ggcaaattt  420
aggtggata  gatacctga  acgtctaca  ccactctca  cattcacaa  gtagagaaa  480
aggacatag  tacctacta  tgtgccttg  tggagggaa  ttataagaa  ctctttggc  540
gtggaacaa  acttgttgt  acagataaa  aacttgatg  agatgtttc  cccaagccc  600
ctatttttc  tccttcaat  gctgaaaca  agctccaga  ggctggaac  tacctttgt  660
ttcttgaga  atttttccc  gatgttatt  agatacatt  gcaagaaaa  aagagcaac  720
cgattctgg  atcccagga  gggaacacc  tgaagacta  cgacacata  atgaaattt  780
gctggttaa  ggtgccaga  aagtcactg  acaaagaac  cagatgtat  gtcagacat  840
agaataata  aaacggagt  gatcaagaa  ttatctttc  tccaataaa  acagatgtc  900
tcacaatgg  tcccaaaga  aattgttca  aagatgcaa  tgatacact  ctgctgcag  960
tcacaaaca  ctctgcata  tacatgtac  tcctcctgc  cctcaagag  gtggtctat  1020
ttgccatca  cacctgctg  ctgcttaga  gaacggctt  ctgctgcaa  ggagagaaa  1080
cataacaga  ggtggcaca  ggaggccat  ttttcctca  cggttattg  ccctagaag  1140
gtcttctga  gatctagtt  ggctttctt  ctgggtttg  gccatttca  ttctcatgt  1200
tgtactatt  tatcattat  gtataacgg  tttcaaacc  gtgggcaca  agagaacct  1260
actctgtaa  aacaatgag  aatagccac  gcgatctcc  gcaccaatc  ctccatgtt  1320
tccacagct  ctccagcca  cccaaatag  gcctgctat  gtgtagaca  cctgcggct  1380
ctagccttg  ccctctctt  gtgttcttt  atcagataa  tgcctggaa  cctttcatt  1440
tacacgccc  gaagcagtc  tctttgcta  ttgaattat  tggtgtgtt  ttccgtaat  1500
agcaaaata  atttaaaaa  atgaaaagtt  1530



<210> 7753
<211> 311
<212> PRT
<213> Homo sapiens
<308> M16768
<400> 7753

Met Leu Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala Leu 
  1               5                  10                  15
Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr 
             20                  25                  30
Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile 
         35                  40                  45
Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu 
     50                  55                  60
Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys 
 65                  70                  75                  80
Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu 
                 85                  90                  95
Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile 
             100                105                110
Ala Thr Tyr Tyr Cys Ala Leu Leu Glu Gly Asn Tyr Lys Lys Leu Phe 
         115                120                125
Gly Ser Gly Thr Thr Leu Val Val Thr Asp Lys Gln Leu Asp Ala Asp 
     130                135                140
Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr Lys 
 145                150                155                160
Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe Phe Pro 
                 165                170                175
Asp Val Ile Lys Ile His Trp Gln Glu Lys Lys Ser Asn Thr Ile Leu 
             180                185                190
Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys 
         195                200                205
Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu Asp Lys Glu His Arg 
     210                215                220
Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val Asp Gln Glu Ile 
 225                230                235                240
Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp 
                 245                250                255
Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn 
             260                265                270
Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val 
         275                280                285
Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys 
     290                295                300
Cys Asn Gly Glu Lys Ser Ter 
 305                310



<210> 7754
<211> 1483
<212> DNA
<213> Rattus norvegicus
<308> S75435
<400> 7754

ggaagaaca  ccacaactt  cgacactga  ctgaccaac  tgtgttggc  aggaaactc  60
gaaccgctc  taactacag  agaccatga  gaaccctgg  tcacaagcc  tctttcctt  120
acatcttcc  tggaaagcc  gcctggcag  tgggaatcc  ctcctgaaa  tagtcatat  180
ttcatgcct  ttgaccttt  gacgtggga  gttggagca  cctgaaata  caatatcca  240
agccagaga  gagactgct  aaatatcct  taaaggttt  gttgaaagc  ttcaaagtg  300
agccataca  tggtaccgg  agaaaccaa  ccaaggttt  gagtttcta  tatatgtcc  360
cgcaactcc  actgagact  tcttaaata  gaagtacaa  aaaatgaag  caagtaaaa  420
ttctagtgc  tctacgtcg  tattgacaa  atattcctt  gaggaagaa  acgaagcta  480
ctactactg  tcctacggc  atagctcgg  ctggagcaa  gtatttgca  aaggaacta  540
actcatagt  gttcctgct  acaaaagct  taatgcaga  atttccccc  agcccacca  600
ttttcttcc  tcttctgct  aaacaaatc  ccacaagac  gggacatac  tttgcctcc  660
tgaaaagtt  ttccccgat  tcataaggg  gtattggaa  gaaaaggac  gcaatacga  720
cctggactc  caggaaggg  agacgctga  gactaacga  acatacatg  agtttagct  780
gcttactgt  cctgaaggg  caatgggta  agagcacag  tgtattgtc  aacacgaga  840
caacaaagg  ggagcagac  aagagattt  ctttccttc  ataaagaaa  ttgctctga  900
tacccagcc  acaacttgc  ggcaagata  aaacgatgt  ctgcagctc  agttcacgg  960
cacctctgc  tactatact  acctgctcc  gctcctcaa  agcgtgctc  acttggcca  1020
catcagctt  tttctgctt  gaagaacag  ttcctgtgg  aataagaag  gatcctaag  1080
aaataaacg  tggaccagc  agtccattg  ttttcatcc  tactgtcat  aaggtgact  1140
atgggggtc  agctgcctt  tcttgctgg  tttgacttc  gtaaagtca  atgcacagc  1200
ttctgttat  gtgcaaaca  ttttctcac  tttgtaagc  atttcagca  cttctctct  1260
actgagctc  ccttcctga  tccatcctc  ccagcagtc  cctccccca  aagcccaaa  1320
tatcaaagc  ctggtacgc  taggctgca  gatttccct  gttgctctt  aaccagtca  1380
ctctctgaa  gcctccgct  tagacaacc  gaagagcct  ctttattgt  ggattctgt  1440
ccttgtatt  catattaga  acaataaat  ttttttaaa  atc  1483



<210> 7755
<211> 331
<212> PRT
<213> Rattus norvegicus
<308> S75435
<400> 7755

Met Lys Asn Pro Gly Ser Gln Ala Leu Phe Pro Leu His Leu Pro Trp 
  1               5                  10                  15
Lys Ala Ser Leu Ala Asp Gly Asn Pro Leu Leu Lys Val Val Ile Phe 
             20                  25                  30
Ser Cys Leu Leu Thr Phe Gly Arg Gly Lys Leu Glu Gln Pro Glu Ile 
         35                  40                  45
Ser Ile Ser Arg Ala Arg Asp Glu Thr Ala Glu Ile Ser Cys Lys Gly 
     50                  55                  60
Phe Val Glu Ser Phe Gln Ser Val Ala Ile His Trp Tyr Arg Gln Lys 
 65                  70                  75                  80
Pro Asn Gln Gly Leu Glu Phe Leu Leu Tyr Val Leu Ala Thr Pro Thr 
                 85                  90                  95
Glu Thr Phe Leu Asn Lys Lys Tyr Lys Lys Met Lys Ala Ser Lys Asn 
             100                105                110
Ser Ser Ala Ser Thr Ser Ile Leu Thr Ile Tyr Ser Leu Glu Glu Glu 
         115                120                125
Asp Glu Ala Ile Tyr Tyr Cys Ser Tyr Gly Tyr Ser Ser Gly Trp Ser 
     130                135                140
Lys Val Phe Ala Glu Gly Thr Lys Leu Ile Val Val Pro Ala Asp Lys 
 145                150                155                160
Ser Phe Asn Ala Asp Ile Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser 
                 165                170                175
Ser Ala Glu Thr Asn Leu His Lys Thr Gly Thr Tyr Leu Cys Leu Leu 
             180                185                190
Glu Lys Phe Phe Pro Asp Val Ile Arg Val Tyr Trp Lys Glu Lys Asp 
         195                200                205
Ser Asn Thr Ile Leu Asp Ser Gln Glu Gly Glu Thr Leu Lys Thr Asn 
     210                215                220
Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Gly Ser Met 
 225                230                235                240
Gly Lys Glu His Arg Cys Ile Val Lys His Glu Asn Asn Lys Gly Gly 
                 245                250                255
Ala Asp Gln Glu Ile Phe Phe Pro Ser Ile Lys Lys Val Ala Leu Ser 
             260                265                270
Thr Gln Pro Thr Thr Cys Trp Gln Asp Lys Asn Asp Val Leu Gln Leu 
         275                280                285
Gln Phe Thr Gly Thr Ser Ala Tyr Tyr Thr Tyr Leu Leu Leu Leu Leu 
     290                295                300
Lys Ser Val Leu Tyr Leu Ala Ile Ile Ser Phe Phe Leu Leu Arg Arg 
 305                310                315                320
Thr Ala Ser Cys Gly Asn Lys Lys Arg Ser Ter 
                 325                330



<210> 7756
<211> 825
<212> DNA
<213> Homo sapiens
<308> X72500
<400> 7756

atgctgtca  tgctccacg  atcaacgct  gcagtcctt  gggctctgt  tgtatatgg  60
gcaggtcac  tagagcaac  tcaaatttc  agtactaaa  cgctgtcaa  aacagcccg  120
ctggaatgt  tggtgtctg  aataacaat  tctgcaaca  ctgtatatt  gtatcgaga  180
agacctggt  aagtcatac  gttcctggt  tccatttca  atgacggca  tgtcagaaa  240
gaatccggc  ttccgtcag  caaatttga  gtggatagg  tacctgaaa  gtctacatc  300
actctcacc  ttcacaatg  agagaaaca  gacatagct  cctactact  tgccttgtg  360
gaggcccag  aagagttgg  caaaaaaat  aaggtattt  gtcccggaa  aaagcttat  420
attacagat  aacaacttg  tgcagatgt  tcccccaag  ccactattt  tcttccttc  480
attgctgaa  caaagctcc  gaaggctgg  acatacctt  gtcttcttg  gaaattttt  540
cctgatgtt  ttaagatac  ttgggaaga  aagaagagc  acacgattc  gggatccca  600
gaggggaac  ccatgaaga  taatgacac  tacatgaaa  ttagctggt  aacggtgcc  660
gaaaagtca  tggacaaag  acacagatg  atcgtcaga  atgagaata  taaaaacgg  720
gttgatcaa  aaattatct  tcctccaat  aagacagat  tcatcacaa  ggatcccaa  780
gacaattgt  caaaagatg  aaatgatac  ctactgctg  agtaa  825



<210> 7757
<211> 275
<212> PRT
<213> Homo sapiens
<308> X72500
<400> 7757

Met Leu Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala Leu 
  1               5                  10                  15
Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr 
             20                  25                  30
Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile 
         35                  40                  45
Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu 
     50                  55                  60
Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys 
 65                  70                  75                  80
Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu 
                 85                  90                  95
Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile 
             100                105                110
Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Ala Gln Gln Glu Leu Gly Lys 
         115                120                125
Lys Ile Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys 
     130                135                140
Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser 
 145                150                155                160
Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu 
                 165                170                175
Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu Glu Lys Lys 
             180                185                190
Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn 
         195                200                205
Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu 
     210                215                220
Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly 
 225                230                235                240
Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr 
                 245                250                255
Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu 
             260                265                270
Leu Gln Ter 
         275



<210> 7758
<211> 1134
<212> DNA
<213> Rattus norvegicus
<308> S75997
<400> 7758

caagcggag  aagagctac  agcagctgc  acgaagact  cctttcttc  tccttgcct  60
tctcactca  tggccctgt  aaacaagat  gtgagtttc  ggaaaaaaa  aaaaaaaaa  120
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  acaggtgac  180
atgccaagt  tgtgagcag  cagtattct  tgaaggtaa  gaagctgga  catgaggct  240
agcaggcaa  ggtggagct  gactttatc  tgtcacagc  gaaggagct  gaagacctt  300
tgagcccgt  agaggagtc  gtgaaggag  aaagtggca  catctacct  cagcatgct  360
atgaggagc  tgagaagac  tacaagctg  ctgagaaca  cgatgctca  ctcaagcgc  420
tggcccagg  cctcaagga  attattgag  acctgaaca  ggctggtgg  cctgcagac  480
ccagtgacc  actgcagca  atctgcaag  tcctcaatg  acacatgga  tcccttcag  540
gggtggacc  gagctctgc  ctgctgcag  ggagggtgg  ggaggccag  cgtgtgtgt  600
agagccggc  caaggaaca  gaacgcagc  tgcgcattg  ctttgacta  ccatacatg  660
gttgggggt  ggggtacct  ttttgttgt  gggctgctg  ctttggggt  gttgtattg  720
tgagaaaaa  gctctttgg  ttggttccc  gttatcaga  gtggtttgc  aaggcatga  780
gtcatggat  taataacct  tgtgctctg  agacaggtg  gaaggtcac  gaactctag  840
ccagcattt  aagaacaag  gcaaactca  cctttagcc  ctccaatac  actgtgaca  900
tgggtcact  gtgtctgca  ggccaccag  catgttcag  tgctcaata  tgtccttga  960
gtcctgggc  atgcgcttg  gctgagcat  gatgttctc  gccagcttg  aggtcttct  1020
acgctcctc  tcagcatgc  gaaggtaga  ggtgccact  tgctccttc  ctgactcct  1080
taacgggct  agaaggtct  ccagctcct  cagctgctt  cgggtttcg  gccg  1134



<210> 7759
<211> 215
<212> PRT
<213> Rattus norvegicus
<308> AAB33384
<400> 7759

Ser Gly Gly Arg Ala Thr Ser Ser Cys Asp Glu Asp Cys Leu Ser Ser 
  1               5                  10                  15
Ser Leu Pro Phe Ser Leu Ser Gly Pro Val Lys Gln Asp Cys Glu Phe 
             20                  25                  30
Leu Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
         35                  40                  45
Lys Lys Lys Lys Lys Lys Lys Lys Thr Gly Asp Asn Ala Lys Ser Val 
     50                  55                  60
Ser Arg Gln Tyr Ser Leu Lys Val Thr Lys Leu Glu His Glu Ala Glu 
 65                  70                  75                  80
Gln Ala Lys Val Glu Leu Asp Phe Ile Leu Ser Gln Gln Lys Glu Leu 
                 85                  90                  95
Glu Asp Leu Leu Ser Pro Leu Glu Glu Ser Val Lys Glu Gln Ser Gly 
             100                105                110
Thr Ile Tyr Leu Gln His Ala Asp Glu Glu Arg Glu Lys Thr Tyr Lys 
         115                120                125
Leu Ala Glu Asn Ile Asp Ala Gln Leu Lys Arg Met Ala Gln Asp Leu 
     130                135                140
Lys Asp Ile Ile Glu His Leu Asn Met Ala Gly Gly Pro Ala Asp Thr 
 145                150                155                160
Ser Asp Pro Leu Gln Gln Ile Cys Lys Ile Leu Asn Ala His Met Asp 
                 165                170                175
Ser Leu Gln Trp Val Asp Gln Ser Ser Ala Leu Leu Gln Arg Arg Val 
             180                185                190
Glu Glu Ala Ser Arg Val Cys Glu Ser Arg Arg Lys Glu Gln Glu Arg 
         195                200                205
Ser Leu Arg Ile Ala Phe Asp 
     210                215



<210> 7760
<211> 3200
<212> DNA
<213> Homo sapiens
<308> NM_016553
<400> 7760

gagctgcga  agggcggga  aggcagttg  agaagaggt  agcggttac  cactccatg  60
ctgcagcaa  gagaggcgg  ggcggcctc  gctgaagaa  gaaggtggg  gcggagagc  120
caggcgtga  atcttccca  ggctgcaga  accgacgga  ttgctttgg  agccagagt  180
gctgccgcc  ccagagtcc  gagccatga  cgggtttaa  tttggaggc  ctggggccc  240
tacaggcgg  ttcacgttt  gcactgcaa  gacggcaac  accacacct  ctacagggt  300
ttctttctc  acctctggc  ctggagggt  taattttgg  gctcccttc  aaccagcca  360
aagtacccc  tccaccggc  tgttctcac  tgccaccca  actccggcc  cacagacga  420
aggcttcac  tttggaaca  cgactcttg  ttcgggggg  actggattt  ctttgggga  480
cggtgcttc  aagctcaac  tgagcaaca  agctgccac  ccagccatg  caaacccca  540
cggctttgg  ctgggcagc  gcaacctca  taatgccat  tcgagcacc  tcacctcca  600
ccagggcac  gcacccacc  gctttgtgt  tggcccctc  accacctct  tggctccag  660
taccacatc  ggaggcttc  cattcactg  tggaagcac  gcccaaccc  ccggtttca  720
cattggctc  gcagggaat  cagcccagc  cacggcacc  gccacgttg  ccttcactc  780
ggccacgcc  gcagccacc  cagcaggtg  cacacagcc  gctgctccc  cacccacag  840
caccatcac  agtactggg  ccagcctct  tgcgtcaat  gcaactgct  caacctcat  900
tgccaccac  ggactctcc  tctgtaccc  tgtgaccac  gcgggcgcc  ccactgctg  960
gacacaggg  ttcagctta  aggcacctg  agcagcttc  ggcacctcc  caacaacat  1020
caccgctgc  accgccacc  ccaccacca  caccagcag  agcaccacc  gctttgcct  1080
gaatttaaa  ccactggcg  cagccggga  ccccagcaa  acagcagct  ccgtgaccg  1140
tccacctgg  cctggcgca  ctgcagggg  ggctgccag  tccgccatg  cctacgcgc  1200
gctggagag  ctgatcaac  aatggagcc  ggagctaga  gaccaggag  ggcacttcc  1260
ccagcaggc  acccaggtc  acgcctggg  ccgcacgct  atcgagaat  gagaaaaga  1320
caccagcct  caccgcgag  tggagaagg  gaagctgga  cagaagagg  tggaccagg  1380
gctcgactt  atcctgtcc  agcagaagg  gctggaaga  ctgctgagc  cactggagg  1440
gttggtcaa  gagcagagc  ggaccatct  cctgcagca  gcggatgag  agcgtgaga  1500
aacctacaa  ctggctgag  acatcgacg  acagctcaa  cgcatggcc  aggatctca  1560
ggacatcat  gagcacctg  acacgtccg  ggcccccgc  gacaccagt  acccactgc  1620
gcagatctg  aagatcctc  atgcgcaca  ggactcact  cagtggatc  accagaact  1680
ggccctgct  cagaggaag  tggaggagg  gaccaaggt  tgcgagggc  ggcgcaagg  1740
gcaggagcg  agcttccgg  tcacctttg  ctgagcgac  gcagccctg  ggcccgcag  1800
tccctaggg  gttcatgag  ggaatgcgc  ctgttgtct  tagtttggg  ttgtggcaa  1860
atacttgtt  gtttgtttc  ttctttcac  tgactgccc  tgacatgat  gctgtgtgc  1920
ttgcgtttt  ccatttagg  gggtattct  ggccttctg  ccaggcagc  gcctcatgg  1980
tgtggcttc  gtggctttc  tttgagtat  tttggcccc  tttcaccta  tgcgaccac  2040
cacctcatc  tggctcagc  tggtgatgg  gaagtgctg  tggtcttgg  cccagccag  2100
gtcgtgggg  cagccactc  ctccaaagc  tagtcatgg  tgtcatgaa  aaataccaa  2160
tgtaagaga  cctccaagt  agggcgcag  ggctcaccc  tgtaatctc  gcactttgg  2220
tggccaagg  gggcagatg  cttgaggtc  ggagttcga  accagcctg  ccaacatgg  2280
gaaaccccg  ctctactaa  aatacaaaa  ttagtcagg  gtggtggac  cctgtgatc  2340
caatctcag  tactcggga  gctgaggca  gagaatcac  tgaacccag  aggtgttgc  2400
gtgaaccaa  atcacacca  tgcactcca  cctaggcaa  agagactct  tctcaaaaa  2460
aaaaaaaaa  aaaagaaac  cccaggaga  agcagccta  ttttcgagt  tgagcttgt  2520
cttgtgaaa  ctaaccatg  taaccacca  ggcaaagca  cacagtgtg  atagaacag  2580
gcgggatca  gaatttcac  gaagacagg  cagctgagg  gcctgcaca  acagggtgt  2640
gaggaacca  agatgggcg  cgagaggcc  gccttttgc  tggcccagg  tcaccccca  2700
cttgggcct  acctcctct  ggaagcctt  ccagctacc  gaagctcag  tggccttct  2760
gcaggtccc  gtagcaccc  gagcctgta  cttgggtgg  acttgttat  ctatcctgt  2820
ctagccgtt  gtgcctcgt  tcgctgtta  attgtgagt  cccatgggc  gagacccac  2880
gtcgttccc  gtgtgtccc  agcccggtc  ctgtcacat  tgttaaatg  aagaacaat  2940
aagcccagt  taacgtcag  ccacagaaa  agccacagc  tccagtggt  gccgtagac  3000
tggctcgga  cttagtggc  ccagagtaa  tctagtcag  tacagtaaa  tccactgtg  3060
gtggaaggc  gaagctagc  gttgtatcc  aagcatctt  tgtatttgt  tttatactt  3120
gctgaattc  ctgaaatac  tattactgt  tgtggcttt  ctaaataaa  gtattgtga  3180
actaaaaaa  aaaaaaaaaa  3200



<210> 7761
<211> 522
<212> PRT
<213> Homo sapiens
<308> P37198
<400> 7761

Met Ser Gly Phe Asn Phe Gly Gly Thr Gly Ala Pro Thr Gly Gly Phe 
  1               5                  10                  15
Thr Phe Gly Thr Ala Lys Thr Ala Thr Thr Thr Pro Ala Thr Gly Phe 
             20                  25                  30
Ser Phe Ser Thr Ser Gly Thr Gly Gly Phe Asn Phe Gly Ala Pro Phe 
         35                  40                  45
Gln Pro Ala Thr Ser Thr Pro Ser Thr Gly Leu Phe Ser Leu Ala Thr 
     50                  55                  60
Gln Thr Pro Ala Thr Gln Thr Thr Gly Phe Thr Phe Gly Thr Ala Thr 
 65                  70                  75                  80
Leu Ala Ser Gly Gly Thr Gly Phe Ser Leu Gly Ile Gly Ala Ser Lys 
                 85                  90                  95
Leu Asn Leu Ser Asn Thr Ala Ala Thr Pro Ala Met Ala Asn Pro Ser 
             100                105                110
Gly Phe Gly Leu Gly Ser Ser Asn Leu Thr Asn Ala Ile Ser Ser Thr 
         115                120                125
Val Thr Ser Ser Gln Gly Thr Ala Pro Thr Gly Phe Val Phe Gly Pro 
     130                135                140
Ser Thr Thr Ser Val Ala Pro Ala Thr Thr Ser Gly Gly Phe Ser Phe 
 145                150                155                160
Thr Gly Gly Ser Thr Ala Gln Pro Ser Gly Phe Asn Ile Gly Ser Ala 
                 165                170                175
Gly Asn Ser Ala Gln Pro Thr Ala Pro Ala Thr Leu Pro Phe Thr Pro 
             180                185                190
Ala Thr Pro Ala Ala Thr Thr Ala Gly Ala Thr Gln Pro Ala Ala Pro 
         195                200                205
Thr Pro Thr Ala Thr Ile Thr Ser Thr Gly Pro Ser Leu Phe Ala Ser 
     210                215                220
Ile Ala Thr Ala Pro Thr Ser Ser Ala Thr Thr Gly Leu Ser Leu Cys 
 225                230                235                240
Thr Pro Val Thr Thr Ala Gly Ala Pro Thr Ala Gly Thr Gln Gly Phe 
                 245                250                255
Ser Leu Lys Ala Pro Gly Ala Ala Ser Gly Thr Ser Thr Thr Thr Ser 
             260                265                270
Thr Ala Ala Thr Ala Thr Ala Thr Thr Thr Thr Ser Ser Ser Thr Thr 
         275                280                285
Gly Phe Ala Leu Asn Leu Lys Pro Leu Ala Pro Ala Gly Ile Pro Ser 
     290                295                300
Asn Thr Ala Ala Ala Val Thr Ala Pro Pro Gly Pro Gly Ala Ala Ala 
 305                310                315                320
Gly Ala Ala Ala Ser Ser Ala Met Thr Tyr Ala Gln Leu Glu Ser Leu 
                 325                330                335
Ile Asn Lys Trp Ser Leu Glu Leu Glu Asp Gln Glu Arg His Phe Leu 
             340                345                350
Gln Gln Ala Thr Gln Val Asn Ala Trp Asp Arg Thr Leu Ile Glu Asn 
         355                360                365
Gly Glu Lys Ile Thr Ser Leu His Arg Glu Val Glu Lys Val Lys Leu 
     370                375                380
Asp Gln Lys Arg Leu Asp Gln Glu Leu Asp Phe Ile Leu Ser Gln Gln 
 385                390                395                400
Lys Glu Leu Glu Asp Leu Leu Ser Pro Leu Glu Glu Leu Val Lys Glu 
                 405                410                415
Gln Ser Gly Thr Ile Tyr Leu Gln His Ala Asp Glu Glu Arg Glu Lys 
             420                425                430
Thr Tyr Lys Leu Ala Glu Asn Ile Asp Ala Gln Leu Lys Arg Met Ala 
         435                440                445
Gln Asp Leu Lys Asp Ile Ile Glu His Leu Asn Thr Ser Gly Ala Pro 
     450                455                460
Ala Asp Thr Ser Asp Pro Leu Gln Gln Ile Cys Lys Ile Leu Asn Ala 
 465                470                475                480
His Met Asp Ser Leu Gln Trp Ile Asp Gln Asn Ser Ala Leu Leu Gln 
                 485                490                495
Arg Lys Val Glu Glu Val Thr Lys Val Cys Glu Gly Arg Arg Lys Glu 
             500                505                510
Gln Glu Arg Ser Phe Arg Ile Thr Phe Asp 
         515                520



<210> 7762
<211> 1950
<212> DNA
<213> Rattus norvegicus
<308> S76742
<400> 7762

ggcagggtg  ggctcaccg  tccccactt  ccggcctcg  ccctctcgt  cgcgttaat  60
agattagca  ttaaaaggc  ggcgagccg  ggccagaga  caggccctg  cgagaagcg  120
gcgcgggac  tggagaagg  acggcctca  tggggcaat  cgctgcagt  cgttttcgc  180
tgtatctcc  acgccgtgg  tttgggcaa  gtgtggcgc  tcccctacc  gtgccagat  240
tacggcgga  ggagtttcc  ggtccccta  ctcatcatg  tcattgtgg  ggggatgcc  300
ctcttgtac  tggagctgg  tgtggggca  cgcatgcgg  agggcagca  tggtgcctg  360
aggaccatc  gcccctacc  tagtggtgt  ggtgttgcc  gtgtggtgg  ctccttctt  420
ctctccatg  actacaatg  catcaatgc  tggggcttc  ggtacctct  ccactcctt  480
caggatccc  tgccgtggt  tgtctgccc  ctgaatagt  accgcacag  ctatgatga  540
gagtgtgag  aggcttcgt  gacacagta  ttctggtac  ggaaaacac  caacatctc  600
ccgtccatc  aggagaatg  aggagtgca  tgggagcca  ccctgtgcc  caccctggc  660
tggctgatg  tatatctgt  catcctgag  ggcaccgaa  ctactggca  ggtggtcta  720
ttcaccgca  tgatgcctt  ctgtgttct  attatctac  tggtccgtg  cctcacact  780
catggagcc  ccaatggcc  gatgtacat  ttcacacct  agattgagc  gctagccaa  840
cccaaggcc  ggatcaatg  agccacgca  atcttcttc  cactgggct  gggttttgg  900
agcctgatc  cttttgcca  ctacaatga  ccctccaac  actgccaga  gcatgctgt  960
attgtgtct  tcatcaaca  ctccacctc  atatttgcc  gcattgtca  cttctccat  1020
tatggcttc  aggccacct  caactatga  aactgctta  acaaggtga  tctgctgct  1080
accaattct  ttgaccttg  agatggctt  ctgacagcc  gcaacctgg  ggaggtgaa  1140
gactacctg  catctactt  cccaaacaa  tacagtgaa  tgttcccac  cattagaaa  1200
tgcagcttg  aatcagagc  gaacacggc  gtccaaggc  caggcctgg  cttcatcgt  1260
tacgctgag  ccattaaaa  catggaagt  tcccagctc  ggtcagtgc  ctacttctt  1320
atgctgctg  tgctgggaa  ggggagcat  cttggaaat  cagcggcca  cctcacccc  1380
ctgactgac  gcaaggtca  ctccagcta  ctgcccaag  aggccattt  aggtctggt  1440
tgcctcatt  actgtgctg  tggcatggt  ttcaccatg  aggctggga  ctactggtt  1500
gacatattc  atgactatg  agccacgct  tctctgctg  tcattgtgc  ggtggagac  1560
atagctgtg  gctacgtgt  tgggctgag  agatttgaa  gtgatcttc  ggccatgac  1620
ggccggccc  tcaactggt  ctggaaggc  atgtgggct  ttgtgagcc  actgctcat  1680
atcggcctc  ttatcttct  cctgagtga  tacatcctc  cgggaacgc  gcagtacca  1740
gcctgggat  ctactcagg  gcagctggt  accaaggat  accctccac  tgcactagc  1800
gtcatcggt  tgctggtgg  ttcatctac  atgtgcatc  ccctggtgg  cctggggac  1860
ttcatcagg  atcgcctca  gaggggagg  tcttcccca  tggcctaag  atggacctc  1920
caaagaccg  agtcagcca  tctgtttcac  1950



<210> 7763
<211> 616
<212> PRT
<213> Rattus norvegicus
<308> AAB32806
<400> 7763

Met Arg Leu Ala Ile Lys Arg Arg Ala Ser Arg Gly Gln Arg Pro Gly 
  1               5                  10                  15
Pro Asp Glu Lys Arg Ala Arg Asp Met Glu Lys Ala Arg Pro Gln Trp 
             20                  25                  30
Gly Asn Pro Leu Gln Phe Val Phe Ala Cys Ile Ser Tyr Ala Val Gly 
         35                  40                  45
Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gln Met Tyr Gly Gly 
     50                  55                  60
Gly Ser Phe Leu Val Pro Tyr Leu Ile Met Leu Ile Val Glu Gly Met 
 65                  70                  75                  80
Pro Leu Leu Tyr Leu Glu Leu Ala Val Gly Gln Arg Met Arg Gln Gly 
                 85                  90                  95
Ser Ile Gly Ala Trp Arg Thr Ile Ser Pro Tyr Leu Ser Gly Val Gly 
             100                105                110
Val Ala Ser Val Val Val Ser Phe Phe Leu Ser Met Tyr Tyr Asn Val 
         115                120                125
Ile Asn Ala Trp Gly Phe Trp Tyr Leu Phe His Ser Phe Gln Asp Pro 
     130                135                140
Leu Pro Trp Ser Val Cys Pro Leu Asn Ser Asn Arg Thr Gly Tyr Asp 
 145                150                155                160
Glu Glu Cys Glu Lys Ala Ser Ser Thr Gln Tyr Phe Trp Tyr Arg Lys 
                 165                170                175
Thr Leu Asn Ile Ser Pro Ser Ile Gln Glu Asn Gly Gly Val Gln Trp 
             180                185                190
Glu Pro Ala Leu Cys Leu Thr Leu Ala Trp Leu Met Val Tyr Leu Cys 
         195                200                205
Ile Leu Arg Gly Thr Glu Ser Thr Gly Lys Val Val Tyr Phe Thr Ala 
     210                215                220
Leu Met Pro Tyr Cys Val Leu Ile Ile Tyr Leu Val Arg Gly Leu Thr 
 225                230                235                240
Leu His Gly Ala Thr Asn Gly Leu Met Tyr Met Phe Thr Pro Lys Ile 
                 245                250                255
Glu Gln Leu Ala Asn Pro Lys Ala Trp Ile Asn Ala Ala Thr Gln Ile 
             260                265                270
Phe Phe Ser Leu Gly Leu Gly Phe Gly Ser Leu Ile Ala Phe Ala Ser 
         275                280                285
Tyr Asn Glu Pro Ser Asn Asp Cys Gln Lys His Ala Val Ile Val Ser 
     290                295                300
Val Ile Asn Ser Ser Thr Ser Ile Phe Ala Ser Ile Val Thr Phe Ser 
 305                310                315                320
Ile Tyr Gly Phe Lys Ala Thr Phe Asn Tyr Glu Asn Cys Leu Asn Lys 
                 325                330                335
Val Ile Leu Leu Leu Thr Asn Ser Phe Asp Leu Glu Asp Gly Phe Leu 
             340                345                350
Thr Ala Ser Asn Leu Glu Glu Val Lys Asp Tyr Leu Ala Ser Thr Tyr 
         355                360                365
Pro Asn Lys Tyr Ser Glu Val Phe Pro His Ile Arg Asn Cys Ser Leu 
     370                375                380
Glu Ser Glu Leu Asn Thr Ala Val Gln Gly Thr Gly Leu Ala Phe Ile 
 385                390                395                400
Val Tyr Ala Glu Ala Ile Lys Asn Met Glu Val Ser Gln Leu Trp Ser 
                 405                410                415
Val Leu Tyr Phe Phe Met Leu Leu Met Leu Gly Met Gly Ser Met Leu 
             420                425                430
Gly Asn Thr Ala Ala Ile Leu Thr Pro Leu Thr Asp Ser Lys Val Ile 
         435                440                445
Ser Ser Tyr Leu Pro Lys Glu Ala Ile Ser Gly Leu Val Cys Leu Ile 
     450                455                460
Asn Cys Ala Val Gly Met Val Phe Thr Met Glu Ala Gly Asn Tyr Trp 
 465                470                475                480
Phe Asp Ile Phe Asn Asp Tyr Ala Ala Thr Leu Ser Leu Leu Leu Ile 
                 485                490                495
Val Leu Val Glu Thr Ile Ala Val Cys Tyr Val Tyr Gly Leu Arg Arg 
             500                505                510
Phe Glu Ser Asp Leu Arg Ala Met Thr Gly Arg Pro Leu Asn Trp Tyr 
         515                520                525
Trp Lys Ala Met Trp Ala Phe Val Ser Pro Leu Leu Ile Ile Gly Leu 
     530                535                540
Phe Ile Phe Tyr Leu Ser Asp Tyr Ile Leu Thr Gly Thr Leu Gln Tyr 
 545                550                555                560
Gln Ala Trp Asp Ala Thr Gln Gly Gln Leu Val Thr Lys Asp Tyr Pro 
                 565                570                575
Pro His Ala Leu Ala Val Ile Gly Leu Leu Val Ala Ser Ser Thr Met 
             580                585                590
Cys Ile Pro Leu Val Ala Leu Gly Thr Phe Ile Arg Asn Arg Leu Lys 
         595                600                605
Arg Gly Gly Ser Ser Pro Val Ala 
     610                615



<210> 7764
<211> 5350
<212> DNA
<213> Homo sapiens
<308> NM_020208
<400> 7764

actgccgtg  cggaccccc  agccggagc  gagcgcgcc  aggccgggg  catggagaa  60
gcgcggccg  tgtgggcca  ctcgctaca  ttcgtgttc  cctgcatct  gtacgccgt  120
ggcctgggc  acgtgtggc  attcccgta  ctgtgccag  tgtacggcg  aggtagttt  180
ctggtcccc  acatcatca  gcttatcgt  gagggaatg  cgctcttgt  cctggaact  240
gctgtgggg  agcgcatgc  gcagggcag  atcggcgcc  ggaggacca  cagcccgta  300
ctcagtggt  tcggggtcg  cagcgtggt  gtctctttc  tcctctcca  gtactacaa  360
gtcatcaac  cctgggcct  ctggtacct  ttccactcc  tccaggatc  cctgccgtg  420
tctgtctgc  cactgaatg  taaccacac  ggctacgat  aggagtgcg  gaaggcgtc  480
tccacacag  acttctggt  caggaaaac  ctcaatatc  cgccgtccc  ccaggagaa  540
gggggtgtg  agtgggagc  ggcgctgtg  ctcctcctg  cctggctgg  ggtgtacct  600
tgcatcctg  gtggcaccg  gtccactgg  aaggtggtg  atttcacgg  gtcactgcc  660
tattgcgtg  tcatcatct  cctcatcag  ggcctcacg  tccacggag  caccaatgg  720
ctcatgtac  tgttcactc  caagataga  cagctggcc  accccaagg  ctggatcaa  780
gcagccacc  agatcttct  ctcacttgg  ctgggcttc  gcagcctga  cgccttcgc  840
agctacaat  agccatcca  caactgcca  aagcacgcc  tcatcgtgt  cctcatcaa  900
agcttcacc  ccatatttg  cagcattgt  accttctcc  tctatggct  caaggccac  960
ttcaattat  aaaactgct  gaagaaggt  agtctgctg  tgaccaaca  ttttgacct  1020
gaagatggc  ttttgacag  cagcaacct  gagcaggtg  agggctacc  cgcatctgc  1080
tacccaagc  aatacagcg  gatgttccc  caaatcaaa  actgcagct  ggaatcgga  1140
ctagacacg  ccgtccagg  cactggcct  gcattcatc  tctacacag  ggccattaa  1200
aacatggag  tgtcccagc  gtggtcggt  ctctacttc  tcatgctgc  gatgctggg  1260
attgggagc  tgctgggga  cacagcggc  atcctcacc  ctctgacag  cagcaagat  1320
atctccagc  acctgccca  ggaggccat  tcaggtctg  tgtgccttg  caactgtgc  1380
attggcatg  tgttcacga  ggaggctgg  aactactgg  ttgacatat  caacgacta  1440
gcggccaca  tgtccctgc  gctcatcgt  ctggtggag  cgattgccg  gtgctacgt  1500
tacgggctg  ggagatttg  aagtgacct  aaggccatg  ccggccgag  tgtgagctg  1560
tactggaag  tgatgtggg  tggcgtaag  ccactgctg  ttgtcagcc  ctttgtctt  1620
tacctgagc  actacatcc  cacggggac  ctgaagtat  aagcctggg  cgcctccca  1680
ggccagctc  tgaccaaag  ttacccggc  tatgcactg  ctgtcatcg  gctgcttgt  1740
gcctcctcc  ccatgtgca  ccccctggc  gccctgggg  cttttgttc  gcgtcgcct  1800
aagagggga  acgcagacc  cgtggcctg  gatgtgggc  tcccagccg  tcacggttt  1860
acagatact  tttacaggc  gaaactcct  ggctgcttt  tcaaatgct  aagccagga  1920
tgctcagcc  atcaacttc  tgagtgtct  aagaagatg  ggaaggtgt  caggaagaa  1980
actcccttg  gagaacgca  accctcccg  ggtggctgt  cctccctgt  acctgcctc  2040
tcatcatgg  agggggtgg  ctatgaaag  cggtctcaa  gataactgc  tccttcatt  2100
caggaaagc  ctagaatta  ggcacattg  aaactgaaa  atgactata  ttcttatgg  2160
accaaattt  agcaatttt  gtttttggc  gaagagaca  caaaatatt  gaggacaaa  2220
atttttaga  ccatttaag  agttttgaa  tgcctaaga  gacctattt  tcagtggtg  2280
aaaattaat  ctcttcttt  ttgagttgt  gtgaatatg  aatttctgt  ttccccttc  2340
accctttaa  tcttaggat  acaagttat  aagaaagaa  atctttgtc  gggaccccc  2400
aagggatcc  ttctctaag  tctctgaca  tgggtccag  accagacct  tctacaaaa  2460
attgcccca  ctacagttt  caaccccaa  ccacattag  agtctgtgc  gacatccct  2520
cgtggtgtg  gtcttggtg  attggaaaa  gagtcagga  ccactgtga  gtgagaatg  2580
aagtggatc  cagctgggc  cggtggctc  cgcctgtaa  cctagcacc  tgggggtca  2640
ggtgggtgg  tcacttgag  tcaggagtt  gaggccagc  tggccaaca  ggcgaaacc  2700
catttctac  aaaaataca  aaaaattag  tgggagtgg  ggcataggc  tgtaattcc  2760
gctactctg  ctgctgagg  acaagaatc  tttgaacct  ggaggtggc  gttgctgtg  2820
gccaagatc  tgccactcc  ctccagtct  ggcgacaga  caagactct  actcaaaaa  2880
aaaaaaaag  ggctctgac  ttcccatag  cttaatatt  catttggac  tcgtggcca  2940
ctctatcaa  accacaaat  ccacttaca  ttaatttta  attattcat  tgtacatag  3000
tttctaaaa  gtatataat  caaacagag  atcttgtaa  tgaagacac  ccatatcta  3060
gatatcgca  tagtccatg  ggggaaaag  aagatcaga  tgttactgt  tctgtgtag  3120
aaaggaaga  ataagaaac  ccattttga  ctgtactaa  aaaaattgt  tctgctttg  3180
gatgttgtt  gcctataac  ttagcccca  ctctgtgct  acagaaaca  gcgctgtaa  3240
gaatcaaag  ttaatggat  tagggctgt  caggatgtg  cttgttaac  atatgtttg  3300
aggctgtat  cttggtaga  gtcatcgcc  ttctccatt  tcgattaac  agggacaca  3360
tgcacagca  aaagctgca  ggacctctg  ccaagaaag  ctgggtatt  tccaaggtt  3420
cccccccac  gagacagcc  gagatatgg  ctcatggga  gggaaagac  tgactgtcc  3480
ccagcccga  acctgtaaa  ggtcggtgc  gaggaggaa  agtgaagga  ggaggcctc  3540
ttgcagttg  gataagagg  aggcttctg  ctcctgctt  tccctggta  tggaatgtc  3600
cggtgtaaa  ctgaccatt  ccattcgtt  tattctgag  taggagaaa  ccgccctgt  3660
gctggaggt  agatatgct  gcagcaata  tgctctgtt  ctccttgct  cactgagat  3720
tttgggtaa  gagaaacat  aatctagcc  acgtgcaca  ctgggcaca  tacctttcc  3780
tgaacttat  cgtgataca  attcctttg  tcacatgtt  ccctgctga  cttcttccc  3840
cctgttgcc  tgctacact  ccctcgcta  gacagtaaa  ataatgatc  ataaatact  3900
agggaactc  gaggccagc  ccggtgcgg  tcctccaca  gctgagcgc  ggtcctggg  3960
ccactgttc  ttctctata  tttgtctct  tgtcttatt  cttttctca  aaaaatttt  4020
cttttttta  ctgcaataa  gtaggtcgt  acccctaaa  tgagcgagt  ccttcctgc  4080
ctaacgtcc  gtgcttcct  gagatcatg  aattctgga  agtttctgt  gatatattt  4140
cacagatat  tttgaagac  caaacactc  cctgggacg  tggccggag  tgtcttttt  4200
tttttgtgc  gtaaaattc  cttacagca  aaataggct  tagaaaggt  ttctactgt  4260
ttcagcaac  atctcatct  ccagcttca  ctgattgtc  agttatcat  catttgact  4320
tcaaatgta  gaaccagca  gtaccccat  gatttaatc  tatctaccc  gtggattca  4380
tcttcttat  agaaggttc  tttatgtca  aaaacctgc  gtcaaggct  gaagagccg  4440
cacactcaa  ggcaaacac  gcaccgagt  tgctctgaa  cctggagga  ctggccctc  4500
tctcaaccc  cactcacag  caccgtctt  caactcagg  ccacctggg  tcagtcatc  4560
gtcagggtg  gtaagcctt  aataccagg  agccgcagg  gtgaaaaga  aaatgtcct  4620
gatcattac  ttattcagt  tccccacct  gcagcgcat  ccaaccacc  gggagcatt  4680
aaaactcca  atgcccaca  cacaccctg  ggccaccca  cagaccttc  ggaagcaag  4740
cctgggcct  catggcccc  aaaactccc  aggtgatcc  atgtgcagc  aaatttgag  4800
ggccccatt  aaaaaagaa  gaacatggg  ggtacattg  ggagtattt  cattttata  4860
aatgactta  aaatttgaa  gcatttttg  gcatttcca  ttatatgga  gagttactt  4920
tacggaata  tttttgctc  tggaactca  acagatgaa  caccactgt  acagaataa  4980
gtgctccag  tgaaaatgt  tcgtttctg  gaatttcat  aagagcaga  catttctca  5040
gaatcctct  gagccagta  tcaatcctg  ctcaaaaaa  gttctttgc  atttcctag  5100
tactgcaca  aagtggcca  gtcgacatt  gtccaccca  cctccaata  gctggagcg  5160
caaagggac  ttccatccc  gtaccctta  tggtagcca  gacacgatg  ccagatcat  5220
gactccgga  agctttctg  ttttactgg  aacatagca  accttgatt  agctccaag  5280
aattgagta  ggaaatatt  gttttttag  aattgtcat  gtaaataaa  ctctaagca  5340
atgtgtgtac  5350



<210> 7765
<211> 592
<212> PRT
<213> Homo sapiens
<308> NP_064593
<400> 7765

Met Glu Lys Ala Arg Pro Leu Trp Ala Asn Ser Leu Gln Phe Val Phe 
  1               5                  10                  15
Ala Cys Ile Ser Tyr Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro 
             20                  25                  30
Tyr Leu Cys Gln Met Tyr Gly Gly Gly Ser Phe Leu Val Pro Tyr Ile 
         35                  40                  45
Ile Met Leu Ile Val Glu Gly Met Pro Leu Leu Tyr Leu Glu Leu Ala 
     50                  55                  60
Val Gly Gln Arg Met Arg Gln Gly Ser Ile Gly Ala Trp Arg Thr Ile 
 65                  70                  75                  80
Ser Pro Tyr Leu Ser Gly Val Gly Val Ala Ser Val Val Val Ser Phe 
                 85                  90                  95
Phe Leu Ser Met Tyr Tyr Asn Val Ile Asn Ala Trp Ala Phe Trp Tyr 
             100                105                110
Leu Phe His Ser Phe Gln Asp Pro Leu Pro Trp Ser Val Cys Pro Leu 
         115                120                125
Asn Gly Asn His Thr Gly Tyr Asp Glu Glu Cys Glu Lys Ala Ser Ser 
     130                135                140
Thr Gln Tyr Phe Trp Tyr Arg Lys Thr Leu Asn Ile Ser Pro Ser Leu 
 145                150                155                160
Gln Glu Asn Gly Gly Val Gln Trp Glu Pro Ala Leu Cys Leu Leu Leu 
                 165                170                175
Ala Trp Leu Val Val Tyr Leu Cys Ile Leu Arg Gly Thr Glu Ser Thr 
             180                185                190
Gly Lys Val Val Tyr Phe Thr Ala Ser Leu Pro Tyr Cys Val Leu Ile 
         195                200                205
Ile Tyr Leu Ile Arg Gly Leu Thr Leu His Gly Ala Thr Asn Gly Leu 
     210                215                220
Met Tyr Met Phe Thr Pro Lys Ile Glu Gln Leu Ala Asn Pro Lys Ala 
 225                230                235                240
Trp Ile Asn Ala Ala Thr Gln Ile Phe Phe Ser Leu Gly Leu Gly Phe 
                 245                250                255
Gly Ser Leu Ile Ala Phe Ala Ser Tyr Asn Glu Pro Ser Asn Asn Cys 
             260                265                270
Gln Lys His Ala Ile Ile Val Ser Leu Ile Asn Ser Phe Thr Ser Ile 
         275                280                285
Phe Ala Ser Ile Val Thr Phe Ser Ile Tyr Gly Phe Lys Ala Thr Phe 
     290                295                300
Asn Tyr Glu Asn Cys Leu Lys Lys Val Ser Leu Leu Leu Thr Asn Thr 
 305                310                315                320
Phe Asp Leu Glu Asp Gly Phe Leu Thr Ala Ser Asn Leu Glu Gln Val 
                 325                330                335
Lys Gly Tyr Leu Ala Ser Ala Tyr Pro Ser Lys Tyr Ser Glu Met Phe 
             340                345                350
Pro Gln Ile Lys Asn Cys Ser Leu Glu Ser Glu Leu Asp Thr Ala Val 
         355                360                365
Gln Gly Thr Gly Leu Ala Phe Ile Val Tyr Thr Glu Ala Ile Lys Asn 
     370                375                380
Met Glu Val Ser Gln Leu Trp Ser Val Leu Tyr Phe Phe Met Leu Leu 
 385                390                395                400
Met Leu Gly Ile Gly Ser Met Leu Gly Asn Thr Ala Ala Ile Leu Thr 
                 405                410                415
Pro Leu Thr Asp Ser Lys Ile Ile Ser Ser His Leu Pro Lys Glu Ala 
             420                425                430
Ile Ser Gly Leu Val Cys Leu Val Asn Cys Ala Ile Gly Met Val Phe 
         435                440                445
Thr Met Glu Ala Gly Asn Tyr Trp Phe Asp Ile Phe Asn Asp Tyr Ala 
     450                455                460
Ala Thr Leu Ser Leu Leu Leu Ile Val Leu Val Glu Thr Ile Ala Val 
 465                470                475                480
Cys Tyr Val Tyr Gly Leu Arg Arg Phe Glu Ser Asp Leu Lys Ala Met 
                 485                490                495
Thr Gly Arg Ala Val Ser Trp Tyr Trp Lys Val Met Trp Ala Gly Val 
             500                505                510
Ser Pro Leu Leu Ile Val Ser Leu Phe Val Phe Tyr Leu Ser Asp Tyr 
         515                520                525
Ile Leu Thr Gly Thr Leu Lys Tyr Gln Ala Trp Asp Ala Ser Gln Gly 
     530                535                540
Gln Leu Val Thr Lys Asp Tyr Pro Ala Tyr Ala Leu Ala Val Ile Gly 
 545                550                555                560
Leu Leu Val Ala Ser Ser Thr Met Cys Ile Pro Leu Ala Ala Leu Gly 
                 565                570                575
Thr Phe Val Gln Arg Arg Leu Lys Arg Gly Asp Ala Asp Pro Val Ala 
             580                585                590



<210> 7766
<211> 711
<212> DNA
<213> Rattus norvegicus
<308> S76758
<400> 7766

taaagcggt  gccggctgg  gcaggaaag  aacaagttc  ccagcggtc  tcccgccct  60
gcctgacaa  ccgaagctt  tcttacctg  cgacaggga  atctcctga  ccgagctca  120
ctttgccac  gccccaggt  tgacctgag  agtgggcaa  ggagcggcg  gcaaattgg  180
ttatttgta  gggggtact  tgaaactcc  tcacttttt  tgggaactt  ttgtgctag  240
gcgcagtga  aggcgttga  aaagctgct  caggaaacg  ccgctatat  gcagggcag  300
tggacagtc  ttggtaacc  cgctcattc  ttagaatca  gtaagaact  aaagggaaa  360
gtgtctctc  gaatgaggg  gtttgcgta  atctatagg  ttttcaaca  cgatgccag  420
tgctttgtc  tctgtaatc  ccaaggtgg  tgagagttg  agcttgcga  attgctttg  480
gttattaga  tcataagtc  caccaagtg  tgggcgatc  actgagcaa  gccaacttc  540
cacatgatg  cttcaaaca  gacacatta  cttccagca  ctgttgggg  gacgagatt  600
taagacact  agtctccag  acagcaaag  cacaatgtt  caccaggtg  gaagggtga  660
gaccatcct  ttccttact  tggttattt  atacttcgg  tgcatgaag  c  711



<210> 7767
<211> 479
<212> DNA
<213> Homo sapiens
<308> AB038670
<400> 7767

tcattcatt  gaatcacgt  agaactcaa  aggaaacgt  tctctcgga  tgagggcgt  60
tgcgtaaat  tataggttt  tcgacatcg  tgccagttg  tttgtcttc  gtagtcgcc  120
aggtggttg  gagtttaag  ttgcggata  tgcaaaggg  tattagatt  ataagtcac  180
ccaagtggt  ggcgatcca  tgagcaaag  cgaacttct  acatgatga  ttcaaacaa  240
acacattac  ttccagcat  tgttgggga  acgagattt  aagacactt  agtctccag  300
acagcaaag  cacaatgtt  caccaggtg  gaagagtga  gaccatcct  ttccttact  360
tggttattt  atactttgg  tgcatgaag  ctgccccca  gaaagaagc  aacatccga  420
gacaaggtg  cttggccta  ccaggtgtg  ggacccatg  gactctgga  agcgtgaat  479



<210> 7768
<211> 47
<212> PRT
<213> Homo sapiens
<308> BAB55545
<400> 7768

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
  1               5                  10                  15
Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
             20                  25                  30
Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn 
         35                  40                  45



<210> 7770
<211> 649
<212> PRT
<213> Rattus norvegicus
<308> AAB21103
<400> 7770

Met Met Asn Gln Ser Gln Arg Met Ala Pro Val Gly Ser Asp Lys Glu 
  1               5                  10                  15
Leu Ser Asp Leu Leu Asp Phe Ser Met Met Phe Pro Leu Pro Val Ala 
             20                  25                  30
Asn Gly Lys Gly Arg Pro Ala Ser Leu Ala Gly Thr Gln Phe Ala Gly 
         35                  40                  45
Ser Gly Leu Glu Asp Arg Pro Ser Ser Glu Ser Trp Gly Asn Ser Glu 
     50                  55                  60
Gln Asn Ser Ser Ser Phe Asp Pro Ser Arg Ala Tyr Ser Glu Gly Ala 
 65                  70                  75                  80
His Phe Ser Asp Ser His Ser Ser Leu Pro Pro Ser Thr Phe Leu Gly 
                 85                  90                  95
Ala Gly Leu Gly Gly Lys Gly Ser Glu Arg Asn Ala Tyr Ala Thr Phe 
             100                105                110
Gly Arg Asp Thr Ser Val Gly Thr Leu Ser Gln Ala Gly Phe Leu Pro 
         115                120                125
Gly Glu Leu Gly Leu Ser Ser Pro Gly Pro Leu Ser Pro Ser Gly Val 
     130                135                140
Lys Ser Ser Ser Gln Tyr Tyr Thr Ser Phe Pro Ser Asn Pro Arg Arg 
 145                150                155                160
Arg Ala Ala Asp Gly Gly Leu Asp Thr Gln Pro Lys Lys Val Arg Lys 
                 165                170                175
Val Pro Pro Gly Leu Pro Ser Ser Val Tyr Pro Ser Ser Ser Gly Asp 
             180                185                190
Asn Tyr Ser Arg Asp Ala Thr Ala Tyr Pro Ser Ala Lys Thr Pro Ser 
         195                200                205
Ser Ala Tyr Pro Ser Pro Phe Tyr Val Ala Asp Gly Ser Leu His Pro 
     210                215                220
Ser Ala Glu Leu Trp Ser Pro Pro Gly Gln Val Gly Phe Gly Pro Met 
 225                230                235                240
Leu Gly Asp Gly Ser Ala Pro Leu Pro Leu Ala Pro Gly Ser Ser Ser 
                 245                250                255
Val Ser Ser Gly Ala Phe Gly Gly Leu Gln Gln Gln Asp Arg Met Gly 
             260                265                270
Tyr Gln Leu His Gly Ser Glu Val Asn Gly Thr Leu Pro Ala Val Ser 
         275                280                285
Ser Phe Ser Ala Ala Pro Gly Thr Tyr Ser Gly Thr Ser Gly His Thr 
     290                295                300
Pro Pro Val Ser Gly Ala Asp Ser Leu Leu Gly Thr Arg Gly Thr Thr 
 305                310                315                320
Ala Ser Ser Ser Gly Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr 
                 325                330                335
Ser Pro Asp His Ser Ser Asn Asn Phe Ser Pro Ser Pro Ser Thr Pro 
             340                345                350
Val Gly Ser Pro Gln Gly Leu Pro Gly Thr Ser Gln Trp Pro Arg Ala 
         355                360                365
Gly Ala Pro Ser Ala Leu Ser Pro Asn Tyr Asp Ala Gly Leu His Gly 
     370                375                380
Leu Ser Lys Met Glu Asp Arg Leu Asp Glu Ala Ile His Val Leu Arg 
 385                390                395                400
Ser His Ala Val Gly Thr Ala Ser Glu Leu His Gly Leu Leu Pro Gly 
                 405                410                415
His Ser Thr Leu Thr Thr Ser Phe Ala Gly Pro Met Ser Leu Gly Gly 
             420                425                430
Arg His Ala Gly Leu Val Ser Gly Ser His Pro Glu Asp Gly Leu Thr 
         435                440                445
Ser Gly Ala Ser Leu Leu His Asn His Ala Ser Leu Pro Ser Gln Pro 
     450                455                460
Ser Ser Leu Pro Asp Leu Ser Gln Arg Pro Pro Asp Ser Phe Ser Gly 
 465                470                475                480
Leu Gly Arg Ala Gly Val Thr Ala Gly Ala Ser Glu Ile Lys Arg Glu 
                 485                490                495
Glu Lys Glu Asp Glu Glu Val Thr Ser Val Ala Asp Ala Glu Glu Asp 
             500                505                510
Lys Lys Asp Leu Lys Val Pro Arg Thr Arg Thr Ser Pro Asp Glu Asp 
         515                520                525
Glu Asp Asp Leu Leu Pro Pro Glu Gln Lys Ala Glu Arg Glu Lys Glu 
     530                535                540
Arg Arg Val Ala Asn Asn Ala Arg Glu Arg Leu Arg Val Arg Asp Ile 
 545                550                555                560
Asn Glu Ala Phe Lys Glu Leu Gly Arg Met Cys Gln Leu His Leu Ser 
                 565                570                575
Thr Glu Lys Pro Gln Thr Lys Leu Leu Ile Leu His Gln Ala Val Ala 
             580                585                590
Val Ile Leu Ser Leu Glu Gln Gln Val Arg Glu Arg Asn Leu Asn Pro 
         595                600                605
Lys Ala Ala Cys Leu Lys Arg Arg Glu Glu Glu Lys Val Ser Gly Val 
     610                615                620
Val Gly Asp Pro Gln Leu Ala Leu Ser Ala Ala His Pro Gly Leu Gly 
 625                630                635                640
Glu Ala His Asn Pro Ala Gly His Leu 
                 645



<210> 7771
<211> 2954
<212> DNA
<213> Homo sapiens
<308> M31222
<400> 7771

acgcgccgc  tgcccggcc  cgcccagca  ggtttccag  cctgaggtg  ccgccctgg  1020
cccaggaga  tgaaccagc  gcagaggat  gcgcctgtg  gcacagaca  ggagctcag  1080
gacctcctg  acttcagca  gatgttccc  ctgcctgtc  ccaacggga  gggccggcc  1140
gcctccctg  ccggggcgc  gttcggagg  tcaggtctt  aggaccggc  cagctcagg  1200
tcctggggc  gcggcgacc  gagcagctc  tcctttgac  ccagccgga  cttcagcga  1260
ggcacccac  tcactgagt  gcacagcag  ctctcttca  ccacattcc  gggaccggg  1320
ctcggaggc  agagcggtg  gcggggcgc  tatgcctcc  tcgggagag  cgcaggcgt  1380
ggcggcctg  ctcaggctg  cttcctgtc  ggcgagctg  ccctcaaca  ccccgggcc  1440
ctgtcccct  cgggcatga  ggggacctc  cagtactac  cctcctact  cggcagctc  1500
cggcggaga  cggcagacg  cagcctaga  acgcagccc  agaaggtcc  gaaggtccc  1560
ccgggtctt  catcctcgg  gtacccacc  agctcaggt  aggactacg  cagggatgc  1620
accgcctac  cgtccgcca  gacccccag  agcacctat  ccgccccct  ctacgtggc  1680
gatggcagc  tgcacccct  agccgagct  tggagtccc  cgggccagg  gggcttcgg  1740
cccatgctg  gtgggggct  atccccgct  cccctcccg  ccggtagcg  cccggtggg  1800
agcagtgga  gcagcagca  gtttggtgg  ctgcaccag  acgagcgta  gggctacca  1860
ctgcatgga  cagaggtga  cggtgggct  ccatctgca  cctccttct  ctcagcccc  1920
ggagccacg  acggcggcg  ctccagcca  acgccgcct  tcagcgggg  cgacagcct  1980
ctgggctcc  gagggacca  agctggcag  tccggggat  ccctcggca  agcactggc  2040
tcgatctac  ccccggatc  ctcaagcaa  aacttctcg  ccagccctt  tacccccgt  2100
ggctccccc  agggcctgg  aggaacgtc  cagtggcct  gagcaggag  ccccggtgc  2160
ttatcgccc  gctacgacg  gggtctcca  ggcctgcag  gtaagatag  agaccacct  2220
gacgaggcc  tccacgtgc  ccgcagcca  gccgtgggc  cagccggcg  catgcacac  2280
ctgctgcct  gccacgggg  gctggcctc  ggtttcacc  gccccatgt  actgggcgg  2340
cggcacgca  gcctggttg  aggcagcca  cccgaggac  gcctcgcag  cagcaccag  2400
ctcatgcac  accacgcgg  cctccccag  cagccaggc  ccctccctg  cctgtctcg  2460
cctcccgac  cctacagtg  gctagggcg  gcaggtgcc  cggcggccg  cagcgagat  2520
aagcgggag  agaaggagg  cgaggagaa  acgtcagcg  ctgaccact  ggaggagga  2580
aagaaggag  tgaaggccc  ccgggcccg  accagccca  acgaggacg  ggacgacct  2640
ctcccccca  agcagaagg  cgagcggga  aaggagcgc  gggtggcca  taacgcccg  2700
gagcggctg  gggtccgtg  catcaacga  gcctttaag  agctggggc  catgtgcca  2760
ctgcacctc  acagcgaga  gccccagac  aaactgctc  tcctgcacc  ggctgtctc  2820
gtcatcctg  acttggagc  gcaagtgcg  gagcggaac  tgaatccca  agcagcctg  2880
ttgaaacgg  gagaagagg  aaaggtgtc  ggtgtggtt  gagaccccc  gatggtgct  2940
tcagctccc  accc  2954



<210> 7772
<211> 654
<212> PRT
<213> Homo sapiens
<308> P15923
<400> 7772

Met Asn Gln Pro Gln Arg Met Ala Pro Val Gly Thr Asp Lys Glu Leu 
  1               5                  10                  15
Ser Asp Leu Leu Asp Phe Ser Met Met Phe Pro Leu Pro Val Thr Asn 
             20                  25                  30
Gly Lys Gly Arg Pro Ala Ser Leu Ala Gly Ala Gln Phe Gly Gly Ser 
         35                  40                  45
Gly Leu Glu Asp Arg Pro Ser Ser Gly Ser Trp Gly Ser Gly Asp Gln 
     50                  55                  60
Ser Ser Ser Ser Phe Asp Pro Ser Arg Thr Phe Ser Glu Gly Thr His 
 65                  70                  75                  80
Phe Thr Glu Ser His Ser Ser Leu Ser Ser Ser Thr Phe Leu Gly Pro 
                 85                  90                  95
Gly Leu Gly Gly Lys Ser Gly Glu Arg Gly Ala Tyr Ala Ser Phe Gly 
             100                105                110
Arg Asp Ala Gly Val Gly Gly Leu Thr Gln Ala Gly Phe Leu Ser Gly 
         115                120                125
Glu Leu Ala Leu Asn Ser Pro Gly Pro Leu Ser Pro Ser Gly Met Lys 
     130                135                140
Gly Thr Ser Gln Tyr Tyr Pro Ser Tyr Ser Gly Ser Ser Arg Arg Arg 
 145                150                155                160
Ala Ala Asp Gly Ser Leu Asp Thr Gln Pro Lys Lys Val Arg Lys Val 
                 165                170                175
Pro Pro Gly Leu Pro Ser Ser Val Tyr Pro Pro Ser Ser Gly Glu Asp 
             180                185                190
Tyr Gly Arg Asp Ala Thr Ala Tyr Pro Ser Ala Lys Thr Pro Ser Ser 
         195                200                205
Thr Tyr Pro Ala Pro Phe Tyr Val Ala Asp Gly Ser Leu His Pro Ser 
     210                215                220
Ala Glu Leu Trp Ser Pro Pro Gly Gln Ala Gly Phe Gly Pro Met Leu 
 225                230                235                240
Gly Gly Gly Ser Ser Pro Leu Pro Leu Pro Pro Gly Ser Gly Pro Val 
                 245                250                255
Gly Ser Ser Gly Ser Ser Ser Thr Phe Gly Gly Leu His Gln His Glu 
             260                265                270
Arg Met Gly Tyr Gln Leu His Gly Ala Glu Val Asn Gly Gly Leu Pro 
         275                280                285
Ser Ala Ser Ser Phe Ser Ser Ala Pro Gly Ala Thr Tyr Gly Gly Val 
     290                295                300
Ser Ser His Thr Pro Pro Val Ser Gly Ala Asp Ser Leu Leu Gly Ser 
 305                310                315                320
Arg Gly Thr Thr Ala Gly Ser Ser Gly Asp Ala Leu Gly Lys Ala Leu 
                 325                330                335
Ala Ser Ile Tyr Ser Pro Asp His Ser Ser Asn Asn Phe Ser Ser Ser 
             340                345                350
Pro Ser Thr Pro Val Gly Ser Pro Gln Gly Leu Ala Gly Thr Ser Gln 
         355                360                365
Trp Pro Arg Ala Gly Ala Pro Gly Ala Leu Ser Pro Ser Tyr Asp Gly 
     370                375                380
Gly Leu His Gly Leu Gln Ser Lys Ile Glu Asp His Leu Asp Glu Ala 
 385                390                395                400
Ile His Val Leu Arg Ser His Ala Val Gly Thr Ala Gly Asp Met His 
                 405                410                415
Thr Leu Leu Pro Gly His Gly Ala Leu Ala Ser Gly Phe Thr Gly Pro 
             420                425                430
Met Ser Leu Gly Gly Arg His Ala Gly Leu Val Gly Gly Ser His Pro 
         435                440                445
Glu Asp Gly Leu Ala Gly Ser Thr Ser Leu Met His Asn His Ala Ala 
     450                455                460
Leu Pro Ser Gln Pro Gly Thr Leu Pro Asp Leu Ser Arg Pro Pro Asp 
 465                470                475                480
Ser Tyr Ser Gly Leu Gly Arg Ala Gly Ala Thr Ala Ala Ala Ser Glu 
                 485                490                495
Ile Lys Arg Glu Glu Lys Glu Asp Glu Glu Asn Thr Ser Ala Ala Asp 
             500                505                510
His Ser Glu Glu Glu Lys Lys Glu Leu Lys Ala Pro Arg Ala Arg Thr 
         515                520                525
Ser Pro Asp Glu Asp Glu Asp Asp Leu Leu Pro Pro Glu Gln Lys Ala 
     530                535                540
Glu Arg Glu Lys Glu Arg Arg Val Ala Asn Asn Ala Arg Glu Arg Leu 
 545                550                555                560
Arg Val Arg Asp Ile Asn Glu Ala Phe Lys Glu Leu Gly Arg Met Cys 
                 565                570                575
Gln Leu His Leu Asn Ser Glu Lys Pro Gln Thr Lys Leu Leu Ile Leu 
             580                585                590
His Gln Ala Val Ser Val Ile Leu Asn Leu Glu Gln Gln Val Arg Glu 
         595                600                605
Arg Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys Arg Arg Glu Glu Glu 
     610                615                620
Lys Val Ser Gly Val Val Gly Asp Pro Gln Met Val Leu Ser Ala Pro 
 625                630                635                640
His Pro Gly Leu Ser Glu Ala His Asn Pro Ala Gly His Met 
                 645                650



<210> 7773
<211> 613
<212> DNA
<213> Rattus norvegicus
<308> S77858
<400> 7773

gcagcagcc  agatgtgtg  cttcaccga  gaccagacc  cagaattca  ggaggcttt  60
cagctgttt  accgaacag  cgatggcaa  atcctgtac  gccagtgtg  ggatgtgat  120
cgggccctg  gccagaacc  taccaacgc  gaggtgctc  aggtcctgg  gaaccccaa  180
agcgatgag  tgaatgtga  ggtgctgga  tttgagcac  tcctgccca  gctgcagac  240
gtggccaag  acaaggacc  aggaaccta  gaggattat  ttgaaggcc  tcgtgtgtt  300
gacaaagaa  ggaatggca  tgtcatggg  gctgaaatc  gtcatgtcc  agtcacact  360
ggggagaag  tgacagagg  agaagtcga  atgctagtg  cggggcatg  ggacagcaa  420
ggttgcatt  actatgaag  gcttctccg  atggtgctg  atggctgag  acatttacg  480
gtctcgagc  tgctccttg  ccagtgtga  attcctgtg  ggccccaga  gctccctaa  540
cacagcacc  tgcctgtct  gtttctttt  gatgatgtt  gccttcacc  aataaaact  600
gctctctgt  ctc  613



<210> 7774
<211> 150
<212> PRT
<213> Rattus norvegicus
<308> AAB34126
<400> 7774

Cys Asp Phe Thr Glu Asp Gln Thr Ala Glu Phe Lys Glu Ala Phe Gln 
  1               5                  10                  15
Leu Phe Asp Arg Thr Gly Asp Gly Lys Ile Leu Tyr Ser Gln Cys Gly 
             20                  25                  30
Asp Val Met Arg Ala Leu Gly Gln Asn Pro Thr Asn Ala Glu Val Leu 
         35                  40                  45
Lys Val Leu Gly Asn Pro Lys Ser Asp Glu Met Asn Val Lys Val Leu 
     50                  55                  60
Asp Phe Glu His Phe Leu Pro Met Leu Gln Thr Val Ala Lys Asn Lys 
 65                  70                  75                  80
Asp Gln Gly Thr Tyr Glu Asp Tyr Val Glu Gly Leu Arg Val Phe Asp 
                 85                  90                  95
Lys Glu Gly Asn Gly Thr Val Met Gly Ala Glu Ile Arg His Val Leu 
             100                105                110
Val Thr Leu Gly Glu Lys Met Thr Glu Glu Glu Val Glu Met Leu Val 
         115                120                125
Ala Gly His Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Glu Leu Leu 
     130                135                140
Arg Met Val Leu Asn Gly 
 145                150



<210> 7775
<211> 4039
<212> DNA
<213> Homo sapiens
<308> M22919
<400> 7775

ctgcaggta  ggccctccc  ccccttcgc  gcgccttac  aggcaagtc  cccgccctt  60
tctcagcca  catagaaaa  cagcggagt  cattctgct  tccggttgc  gcacgggct  120
cagcgcttc  caactttgg  ttttttcca  agatccagt  gggtccgga  atgggcccc  180
caggcgaaa  gaacgttcc  gccaccagg  ggccacctn  ttgtttcaa  aataaagac  240
ggttcctct  ttggtttca  actgctatt  ttttcatgg  tggggatca  cgggagacg  300
ggaggtgct  ggaggagag  gcgggaaaa  agggctctc  cctcttcca  tcctctgat  360
ttcctgtgt  gggagggtc  gattactgt  ccccagccc  cgtcccccc  cgacccccg  420
acccccacc  ccccccacg  cccccccca  ctccgagcg  gttctgtgc  caggtggcg  480
tggagaaag  aacagcgga  cccgcccaa  tcattacta  tgtagcaat  gtcttgcat  540
aacccaggc  acggttcct  ttggctgaa  tcctctgag  tgacgtcat  gggacgtac  600
aagactagg  ttgggccga  agtcggagc  attactgca  gaaaaggtc  cggagagct  660
agcagtcaa  atggtgggg  ccaggtctt  ggagacggg  aggattggg  acgagaggc  720
ggaagagac  ggtcggggg  cgaggagaa  gcaggggta  gaggcaaag  gaatctgag  780
acccgaaag  tggaggtgg  gttggaaag  ctggggccc  gcggggcaa  cgagtctgc  840
gcctgaaac  ggagctttg  gggtcagag  ttgtgggtc  gagtttgtg  ggctgggat  900
gaaactggg  gattggcgt  cagatgctg  ccacttccc  cttctctga  cagtgtgac  960
tcaccgaag  ccagaccgc  ggtaggtta  ctctgatcc  taccgaggt  cacccttag  1020
gagagggac  ccctccccc  agcacctat  ctctaatct  aatctgtca  ctctttagc  1080
cccccatga  attaccccc  ggattattt  ctcttcttc  ggatcctcc  ttttctttt  1140
tcactttct  cctccctcc  cttccactc  agatctgat  ccaagcact  ggtgagttt  1200
aggtggtgt  ggtatgaaa  aacttggtc  cttaatgcc  gctgtgtgt  gggtctggg  1260
gggtgtata  agctgcctg  tttcctttg  cctttaatc  gctacttct  cctcttttc  1320
cctcttgtg  taactgtcc  cgccctccc  gcttcgagc  cgttgtgaa  attgtagag  1380
agtgacctg  tattgtgtc  gatggggca  agacagggg  gtttgctaa  gataatgac  1440
gtagctata  ctctggaag  tctcttata  actggaggg  tgcgaagtg  ctggttggg  1500
tgtccctag  cccaggctg  tgctcccac  tccttataa  gacaggact  agactgggc  1560
gtggcgaat  ccagccctg  gaagtgtag  agcagcagt  gagattggc  ggcctccgc  1620
caggaagtg  gagttgtgt  aatggatgt  accaggctg  cagaagggg  ggaagcctc  1680
atatagaac  ctttgagtt  ggaggaaga  aaatagagc  ctcttaagt  gactttggt  1740
tacagtttg  tgcagatat  tcgtttcct  agcatgatc  aagttgaat  ggcacgaga  1800
ctctgaggt  gggtttgga  taaccctca  atcctgtgt  gacattcat  tgaatccta  1860
agttcaagg  ggccttcca  ctgtttgac  gaacaggtg  tggcaagat  ctgtacagc  1920
agtgtgggg  tgtgatgag  gccctgggc  agaacccta  caacgcgga  gtgctcaag  1980
tcctgggga  ccccaagag  gatggtgag  ggcctaaag  acaactcct  attgtcatg  2040
gcccacatt  ttcagctaa  agcttccct  tatcttcat  ggccccaaa  tcaagcaag  2100
ctggattac  aaatcccat  gatttcctt  cttttagtg  ggagtcatc  gtcatctct  2160
tgttcagtt  aggtctcta  aatcccctg  cctgagaac  tgtgttact  ctctggcct  2220
acacttcac  tcctttatg  cagagatga  tgtgaaggt  ctggacttt  agcactttc  2280
gcccatgct  cagacagtg  ccaagaaca  ggaccaggg  acctatgag  attatgtcg  2340
aggacttcg  gtgtttgac  aggaaggaa  tggcaccgt  atgggtgct  aaatccggc  2400
tgttcttgt  acactgggt  aggttctgt  tccttgtcc  tgagctgag  tggcaccct  2460
ggtacctca  ttgtcaccc  attccaaaa  tgctttctt  ccccctgca  gtgagaaga  2520
gacagagga  gaagtagag  tgctggtgg  agggcatga  gacagcaat  gttgtatca  2580
ctatgaagg  aagaggtga  ctgcgcttt  tcagagaaa  cagccatat  gggcaggtc  2640
agtatagtg  ctggggctt  ccctatccc  ggacttggg  tccaaaaag  gccaggagg  2700
aaggtgcag  gccctgcca  cccagccca  gagtgggag  tcagggcgg  ataacagga  2760
aggaagggg  tagtagtgt  gagggtggg  aggaatgag  agtgaaata  tggaatgtc  2820
gtcccactg  ctgacccct  accccatgt  tttgtactt  tcttcaacc  ttaatgtct  2880
ttccttcct  cagcgtttg  gaggcatat  ctgtcgggg  gacgggccc  tggggcggt  2940
cggctcctc  cagcctctc  tctagttga  ctccccagt  tttcttttt  ccccaacct  3000
tgctcttta  cccctgccc  taccctact  cnatctgac  tcntcctgg  atgtttctg  3060
atggagctg  ctagggagg  gagggattc  caaagagga  gaccaacct  ggggtacag  3120
acctcctta  tctagaatg  gccctgagg  tttacttat  cggccctgg  tgctggtgt  3180
tgggaacct  accagcctg  ataccagtc  tgctttagg  tgaccttct  gccctggag  3240
atgggtagc  ggcatagag  ggtatgggt  gcctgcccc  ttctgctgc  atagctgaa  3300
agtcctttc  ccttccctc  ctgggcagc  tggcaggta  cctaaccca  aactctgtc  3360
tctcctccc  ccagtggct  acagtagct  taggtgtag  ggagaactt  tctgcctct  3420
ctgtgttct  gctgcttag  tttgggtgg  ggactaaca  ctgctggga  gggagctag  3480
ggcatggag  actggtcag  ctcaaggtg  ctcctctgc  aactgaccc  agggttggt  3540
gctgtgggc  tgttcccgc  tatgctacc  ttgcagtct  gtagtcccc  ggcccttgg  3600
gtacccctc  acagccctg  tccctggct  atcccacct  tcctttcca  agagctcgt  3660
cgcatggtg  tgaatggct  aggaccttc  cagtctccc  agagtccgt  cctttccct  3720
tgtgaattt  gtatctagc  taaagtttc  ctaggcttt  ttgtctcag  aactttccc  3780
tcttgtctc  cttggatga  gtttgccgt  agcattcac  aaataaact  gctctctgg  3840
ccctcggtt  ggttctttc  ttcctgaac  gggtaaagg  gaagaaggt  agatggtga  3900
gatttctgc  ctgaggcag  gtccaaggt  aatcaatgg  gcaggggtt  aggaaagct  3960
ggggaggcc  tgtactagc  atctgggct  catttaaaa  ctactggcc  cattcatcc  4020
tcttacaca  ctacctctt  4039



<210> 7776
<211> 150
<212> PRT
<213> Homo sapiens
<308> AAA59893
<400> 7776

Cys Asp Phe Thr Glu Asp Gln Thr Ala Glu Phe Lys Glu Ala Phe Gln 
  1               5                  10                  15
Leu Phe Asp Arg Thr Gly Asp Gly Lys Ile Leu Tyr Ser Gln Cys Gly 
             20                  25                  30
Asp Val Met Arg Ala Leu Gly Gln Asn Pro Thr Asn Ala Glu Val Leu 
         35                  40                  45
Lys Val Leu Gly Asn Pro Lys Ser Asp Glu Met Asn Val Lys Val Leu 
     50                  55                  60
Asp Phe Glu His Phe Leu Pro Met Leu Gln Thr Val Ala Lys Asn Lys 
 65                  70                  75                  80
Asp Gln Gly Thr Tyr Glu Asp Tyr Val Glu Gly Leu Arg Val Phe Asp 
                 85                  90                  95
Lys Glu Gly Asn Gly Thr Val Met Gly Ala Glu Ile Arg His Val Leu 
             100                105                110
Val Thr Leu Gly Glu Lys Met Thr Glu Glu Glu Val Glu Met Leu Val 
         115                120                125
Ala Gly His Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Glu Leu Val 
     130                135                140
Arg Met Val Leu Asn Gly 
 145                150



<210> 7777
<211> 1008
<212> DNA
<213> Rattus norvegicus
<308> S77900
<400> 7777

acacccaaa  ccaagatgt  cagcaagag  gccaaggcc  agaccacca  gaagaggcc  60
cagagcgct  cgtccaatg  cttcgctat  tttgaccag  cccagatcc  ggagtttaa  120
gaggccttc  acatgattg  tcagaaccg  gatggcttc  ttgacaagg  ggacctaca  180
gacatgctg  cctccctgg  gaagaaccc  acggatgag  acctggagg  tatgatgaa  240
gaggccccg  gacctatca  cttcaccat  ttcctcact  tgtttgggg  gaagctgaa  300
ggcacagac  ccgaggacg  gatccgcaa  gcctttgcc  gctttgatg  ggaagcctc  360
gggttcatc  acgaggacc  cctgcggga  ctgctcacc  ccatgggcg  ccgattcac  420
gatgaggag  tggacgaga  gtaccgtga  cgcattgat  agaagggca  cttcaacta  480
gtggagttc  ctcgcatcc  caagcacgg  gccaaggac  aagacgact  ggctcttct  540
agctgtccc  atgcctaca  cccatccca  tcacctcct  aacaacaca  acactctac  600
ctccccatg  ggagttagg  tcccggctc  cagggcagg  aatgagcca  taagacgca  660
agggtgagg  taggggttc  accacggac  caggcacta  aggaagggc  acagtgggg  720
ggtgagcca  gggtggggc  agctagcac  aaagtgaag  aagccactg  agatggcca  780
cctcagcca  gccctccca  tccagggct  ccctgagga  gaaaacacc  atgttctgg  840
gttggacac  aattcccag  atccccaca  aggtacaca  ccattcacc  tgtcccttc  900
gaggatgac  gtctgcact  cacctatgg  gttgtccca  cacacccag  atgcataga  960
ggacgctgc  tgagggaca  attctctaa  acaaggctg  gcacaaaa  1008



<210> 7778
<211> 170
<212> PRT
<213> Rattus norvegicus
<308> AAB34127
<400> 7778

Ser Ser Lys Arg Ala Lys Ala Lys Thr Thr Lys Lys Arg Pro Gln Ser 
  1               5                  10                  15
Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln Glu 
             20                  25                  30
Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe Ile 
         35                  40                  45
Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn Pro 
     50                  55                  60
Thr Asp Glu Xaa Leu Glu Gly Met Met Asn Glu Ala Pro Gly Pro Ile 
 65                  70                  75                  80
Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly Thr 
                 85                  90                  95
Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu Glu 
             100                105                110
Ala Ser Gly Phe Ile His Glu Asp His Leu Arg Glu Leu Leu Thr Thr 
         115                120                125
Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Met Tyr Arg Glu 
     130                135                140
Arg Ile Asp Lys Lys Gly Asn Phe Asn Tyr Val Glu Phe Thr Arg Ile 
 145                150                155                160
Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
                 165                170



<210> 7779
<211> 1116
<212> DNA
<213> Homo sapiens
<308> XM_009501
<400> 7779

ggaagcccc  cccaccaga  gccaagatg  ccagcaagc  ggccaaagc  aagaccacc  60
agaagcggc  acagcgggc  acatccaat  tcttcgcaa  gtttgacca  tcccagatc  120
aggagttta  ggaggcttt  aacatgatt  accagaacc  tgatggctt  attgacaag  180
aggacctgc  cgacatgct  gcctcgctg  ggaagaacc  cacagacga  tacctggag  240
gcatgatga  cgaggcccc  gggcccatc  acttcacca  gttcctcac  atgtttggg  300
agaagctga  cggcacgga  cccgaggat  tgattcgca  cgcctttgc  tgcttcgac  360
aggaagcct  aggtttcat  catgaggac  acctccggg  gctgctcac  accatgggt  420
accgcttca  agatgagga  gtggacgag  tgtaccggg  ggcacccat  gataagaaa  480
gcaacttca  ctacgtgga  ttcacccgc  tcctcaaac  tggcgccaa  gataaagac  540
actaggcca  cccagcccc  tgacacccc  gcccccgcc  gtcacccct  cccgcacac  600
cccgtccat  ccagctccc  gcccatgac  ctcgctcag  gatccccct  tgaggggtt  660
gggtcccag  tcccagtgg  agaaacagg  caggagaag  gcgtgccga  ctgaggcag  720
tgttcccac  gtgacccca  agccctggg  tatagtctc  gacccctcc  aggaaagac  780
accttctgg  gacatgggc  ggagggcag  acctagagg  accaaggga  ggccccatt  840
cggggctgt  ccccgagga  gaagggaag  ggctctgtg  gccccccag  aggaagagg  900
cctgagtcc  gggatcaga  accccttca  gtgtatccc  acacaaatg  aagctcacc  960
aggtcccct  tcagtcccc  tccctacac  ctgaccggc  actgccgca  acccaccca  1020
agcacgcca  ccgccatgg  agtgtgctc  ggagtcgcg  gcagcgtgg  catctgtcc  1080
agagggggc  gaatctcca  tagaggact  agcact  1116



<210> 7780
<211> 172
<212> PRT
<213> Homo sapiens
<308> XP_009501
<400> 7780

Met Ser Ser Lys Arg Ala Lys Ala Lys Thr Thr Lys Lys Arg Pro Gln 
  1               5                  10                  15
Arg Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln 
             20                  25                  30
Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe 
         35                  40                  45
Ile Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn 
     50                  55                  60
Pro Thr Asp Glu Tyr Leu Glu Gly Met Met Ser Glu Ala Pro Gly Pro 
 65                  70                  75                  80
Ile Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly 
                 85                  90                  95
Thr Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu 
             100                105                110
Glu Ala Ser Gly Phe Ile His Glu Asp His Leu Arg Glu Leu Leu Thr 
         115                120                125
Thr Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Met Tyr Arg 
     130                135                140
Glu Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Val Glu Phe Thr 
 145                150                155                160
Arg Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
                 165                170



<210> 7781
<211> 1008
<212> DNA
<213> Rattus norvegicus
<308> S77900
<400> 7781

acacccaaa  ccaagatgt  cagcaagag  gccaaggcc  agaccacca  gaagaggcc  60
cagagcgct  cgtccaatg  cttcgctat  tttgaccag  cccagatcc  ggagtttaa  120
gaggccttc  acatgattg  tcagaaccg  gatggcttc  ttgacaagg  ggacctaca  180
gacatgctg  cctccctgg  gaagaaccc  acggatgag  acctggagg  tatgatgaa  240
gaggccccg  gacctatca  cttcaccat  ttcctcact  tgtttgggg  gaagctgaa  300
ggcacagac  ccgaggacg  gatccgcaa  gcctttgcc  gctttgatg  ggaagcctc  360
gggttcatc  acgaggacc  cctgcggga  ctgctcacc  ccatgggcg  ccgattcac  420
gatgaggag  tggacgaga  gtaccgtga  cgcattgat  agaagggca  cttcaacta  480
gtggagttc  ctcgcatcc  caagcacgg  gccaaggac  aagacgact  ggctcttct  540
agctgtccc  atgcctaca  cccatccca  tcacctcct  aacaacaca  acactctac  600
ctccccatg  ggagttagg  tcccggctc  cagggcagg  aatgagcca  taagacgca  660
agggtgagg  taggggttc  accacggac  caggcacta  aggaagggc  acagtgggg  720
ggtgagcca  gggtggggc  agctagcac  aaagtgaag  aagccactg  agatggcca  780
cctcagcca  gccctccca  tccagggct  ccctgagga  gaaaacacc  atgttctgg  840
gttggacac  aattcccag  atccccaca  aggtacaca  ccattcacc  tgtcccttc  900
gaggatgac  gtctgcact  cacctatgg  gttgtccca  cacacccag  atgcataga  960
ggacgctgc  tgagggaca  attctctaa  acaaggctg  gcacaaaa  1008



<210> 7782
<211> 170
<212> PRT
<213> Rattus norvegicus
<308> AAB34127
<400> 7782

Ser Ser Lys Arg Ala Lys Ala Lys Thr Thr Lys Lys Arg Pro Gln Ser 
  1               5                  10                  15
Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln Glu 
             20                  25                  30
Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe Ile 
         35                  40                  45
Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn Pro 
     50                  55                  60
Thr Asp Glu Xaa Leu Glu Gly Met Met Asn Glu Ala Pro Gly Pro Ile 
 65                  70                  75                  80
Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly Thr 
                 85                  90                  95
Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu Glu 
             100                105                110
Ala Ser Gly Phe Ile His Glu Asp His Leu Arg Glu Leu Leu Thr Thr 
         115                120                125
Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Met Tyr Arg Glu 
     130                135                140
Arg Ile Asp Lys Lys Gly Asn Phe Asn Tyr Val Glu Phe Thr Arg Ile 
 145                150                155                160
Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
                 165                170



<210> 7783
<211> 1116
<212> DNA
<213> Homo sapiens
<308> XM_009501
<400> 7783

ggaagcccc  cccaccaga  gccaagatg  ccagcaagc  ggccaaagc  aagaccacc  60
agaagcggc  acagcgggc  acatccaat  tcttcgcaa  gtttgacca  tcccagatc  120
aggagttta  ggaggcttt  aacatgatt  accagaacc  tgatggctt  attgacaag  180
aggacctgc  cgacatgct  gcctcgctg  ggaagaacc  cacagacga  tacctggag  240
gcatgatga  cgaggcccc  gggcccatc  acttcacca  gttcctcac  atgtttggg  300
agaagctga  cggcacgga  cccgaggat  tgattcgca  cgcctttgc  tgcttcgac  360
aggaagcct  aggtttcat  catgaggac  acctccggg  gctgctcac  accatgggt  420
accgcttca  agatgagga  gtggacgag  tgtaccggg  ggcacccat  gataagaaa  480
gcaacttca  ctacgtgga  ttcacccgc  tcctcaaac  tggcgccaa  gataaagac  540
actaggcca  cccagcccc  tgacacccc  gcccccgcc  gtcacccct  cccgcacac  600
cccgtccat  ccagctccc  gcccatgac  ctcgctcag  gatccccct  tgaggggtt  660
gggtcccag  tcccagtgg  agaaacagg  caggagaag  gcgtgccga  ctgaggcag  720
tgttcccac  gtgacccca  agccctggg  tatagtctc  gacccctcc  aggaaagac  780
accttctgg  gacatgggc  ggagggcag  acctagagg  accaaggga  ggccccatt  840
cggggctgt  ccccgagga  gaagggaag  ggctctgtg  gccccccag  aggaagagg  900
cctgagtcc  gggatcaga  accccttca  gtgtatccc  acacaaatg  aagctcacc  960
aggtcccct  tcagtcccc  tccctacac  ctgaccggc  actgccgca  acccaccca  1020
agcacgcca  ccgccatgg  agtgtgctc  ggagtcgcg  gcagcgtgg  catctgtcc  1080
agagggggc  gaatctcca  tagaggact  agcact  1116



<210> 7784
<211> 172
<212> PRT
<213> Homo sapiens
<308> XP_009501
<400> 7784

Met Ser Ser Lys Arg Ala Lys Ala Lys Thr Thr Lys Lys Arg Pro Gln 
  1               5                  10                  15
Arg Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln 
             20                  25                  30
Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe 
         35                  40                  45
Ile Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn 
     50                  55                  60
Pro Thr Asp Glu Tyr Leu Glu Gly Met Met Ser Glu Ala Pro Gly Pro 
 65                  70                  75                  80
Ile Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly 
                 85                  90                  95
Thr Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu 
             100                105                110
Glu Ala Ser Gly Phe Ile His Glu Asp His Leu Arg Glu Leu Leu Thr 
         115                120                125
Thr Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Met Tyr Arg 
     130                135                140
Glu Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Val Glu Phe Thr 
 145                150                155                160
Arg Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
                 165                170



<210> 7785
<211> 1508
<212> DNA
<213> Rattus norvegicus
<308> S78217
<400> 7785

aaagatgtc  taggctggg  tgaaaatga  agaggagtg  ccttcacat  tggtgcaga  60
gtggttgca  aatttctcc  taagcatga  ttggatctt  tatgtagag  ccatcaggt  120
gttgaagat  gatatgagt  ttttgcaaa  aggcagtta  tcactctgt  ttctgcacc  180
aactactgt  gcgagtttg  caatgcggg  gccatgatg  gtgtggatg  gaccctcat  240
tgctccttc  agattttaa  gcctgcaga  aaaaagaag  ccaatgcca  gagacctgt  300
acaccgcca  ggggtatga  cacaaagca  gcaaagaaa  agatgtcac  tgacactgc  360
tagtgggac  tgtaacata  cgtacataa  cttcctttt  aaactgtat  tgtgctggt  420
agcttgccc  ggtagacct  tcgggccct  ccttctcca  tttgattat  gctggcact  480
gctggttat  gcagcaagt  aagcatttc  ttctcaaga  agcgtttgt  tttgtttgt  540
tttaacctc  gttcccttt  tggacagct  tgatgatgg  gttaagctg  acaccttgg  600
agtttatcc  gtcccaagt  aagcatttc  ttctcaaga  agcgtttgt  tttgtttgt  660
tttaacctc  gttcccttt  tggacagct  ggatataaa  agagcccta  ggtgcgtga  720
tctgtacat  taattgtca  aaatgcatt  tgttgatac  aaccactgt  aacagtttt  780
ccaagtttg  ttgacaggg  ctgctttcc  tcactgtct  atcctgtac  aactagtgt  840
tgcagctgt  gcagcagga  caacctgcc  ccctgccac  cacactgcc  aggctgtct  900
aagcacact  cctcccact  cacacttaa  tgacgatta  agccattct  ttcaatgtc  960
gtgattcct  cctaaagcc  aagtttctg  tggactgta  tggcacacc  tggacatga  1020
gtggccagg  caccaaggc  gctggcaca  gccgcctcc  tggggactc  gaaagaagc  1080
ggttatttt  actagcaat  gtgatgtag  gctgggtaa  ctattaatg  tggaagtta  1140
tgagacatt  tacagtgcc  atatagtct  ttcactgag  aatcttttt  cagttggat  1200
aggcctgaa  ccgtccatt  agaaagctt  aaattatag  aacaacact  tcctatacg  1260
gtgatcgat  atgctttct  tggctacat  ctttattct  cggtgacat  gaggcttat  1320
aatcaaaag  aactaactt  ccgtccacc  gtttataca  aactcacag  atctatgac  1380
tttttaaac  acgacctgt  aaaatgaat  tgtttccac  gatgccgtg  acaatgcca  1440
gtgctaaga  tgatttcag  cttattaaa  gcgagcttg  taacctgtc  aaaaaaaaa  1500
aaaaaaaa  1508



<210> 7786
<211> 113
<212> PRT
<213> Rattus norvegicus
<308> AAB34334
<400> 7786

Lys Asp Val Leu Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe Thr 
  1               5                  10                  15
Phe Gly Ala Glu Val Val Ala Lys Phe Leu His Lys His Asp Leu Asp 
             20                  25                  30
Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe Phe 
         35                  40                  45
Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys Gly 
     50                  55                  60
Glu Phe Asp Asn Ala Gly Ala Met Met Ser Val Asp Glu Thr Leu Met 
 65                  70                  75                  80
Cys Ser Phe Gln Ile Leu Lys Pro Ala Glu Lys Lys Lys Pro Asn Ala 
                 85                  90                  95
Thr Arg Pro Val Thr Pro Pro Arg Gly Met Ile Thr Lys Gln Ala Lys 
             100                105                110
Lys 
         115



<210> 7787
<211> 2263
<212> DNA
<213> Homo sapiens
<308> NM_002710
<400> 7787

aggaagtag  gagcggggt  gcagggggg  gacccgccg  ggctgctgc  accgccgcc  60
ccaccgcct  tgctcgtgg  gtgggaaag  aggtgtgag  cccgggcgc  agccgcggc  120
gcgccgctg  gggagggtc  gcggtggga  ggcgatggc  gatttagat  aactcaaca  180
cgacagcat  atccaacgg  tgctggaag  gagagggtc  aagcctggt  agaatgtcc  240
gcttcagga  aatgaaatc  gaggactgt  cttaaagtc  cgtgaaatc  ttctcagtc  300
gcctatcct  ctagaactt  aagcaccac  caaaatatg  ggtgacatc  atggacaat  360
ctatgattt  ctgcgactt  ttgagtacg  tggtttccc  ccagaaagc  actacctgt  420
tcttgggga  tatgtggac  ggggaaagc  gtcattgga  acgatctgc  tcttactgg  480
ctacaaaat  aaatatcct  agaattttt  tcttctcag  gggaaccat  aatgtgcca  540
catcaacag  atttatgga  tttatgatg  atgtaaaag  agatacaac  ttaaactat  600
gaaaacttt  acagactgt  ttaactgtt  accgatagc  gccatcgtg  atgagaaga  660
attctgctg  catggaggt  tatcaccag  tcttcaatc  atggagcag  ttcggcgaa  720
tatgcgacc  actgatgta  cagatcaag  tcttctttg  gatcttttg  ggtctgacc  780
cgataaaga  gtcttaggc  ggggtgaaa  tgacagagg  gtgtccttc  catttggtg  840
agaagtggt  gcaaaattt  tccataagc  tgatttgga  cttatatgt  gagcccatc  900
ggtggttga  gatggatat  aattttttg  aaagaggca  ttggtcact  tgttttctg  960
gcccaatta  tgcggagag  ttgacaatg  aggtgccat  atgagtgtg  atgaaacac  1020
aatgtgttc  tttcagatt  taaagcctg  agagaaaaa  aagccaaat  ccacgagac  1080
tgtaacgcc  ccaaggggt  tgatcacaa  gcaagcaaa  aaatagatg  cgttttgac  1140
ctgcctagt  gggacttgt  acatagagt  tataacctt  atttttaag  ctgtaatgt  1200
tactggtca  cttgctcag  tagatctgt  tttgtgggg  cccttcctt  catttttga  1260
ttagtgaat  gcatttgct  gttataaca  caaatgaaa  actcttcac  ccaaaaaga  1320
aagtgtttt  ttttttaat  ctctgttcc  tttgcaaac  attttaatg  tggtgttaa  1380
gctgtacac  ccaggacag  ttatcctgt  tgaggagta  gtgtacaat  gatcttttt  1440
aattcagta  aacccataa  catgtaaat  ctcattttc  ttaggacat  aagagagcc  1500
tagggtgct  tgaatctgt  catgttctt  tcataaaat  catactgtt  atacaaacc  1560
ctgtgaaca  tttttattt  agaattttg  ttcaaaggg  ttgcttttt  ctctcattg  1620
cttgttatg  acaaactag  ttttatagc  atcaacatt  ggagtaact  tcaaccttg  1680
cagcatcac  ggtatgatg  atatttaat  aaagcacac  tttccccga  cgtatactt  1740
aaatgacaa  gccattctt  taaatattt  tgactcttt  ctaaagcca  agtttctgt  1800
gaattatgt  ttgacacac  cctaagtac  aggtggtat  gttgtatac  catgctgcc  1860
tcttgggga  tcaaaaaca  gtttttgat  ttgaatagc  attagtgat  tagtgctgt  1920
taagctact  acgataaaa  gtaataaca  tttatacaa  ttccatata  tctattcat  1980
aagtaatct  tttacagtt  catcaggcc  gaacccgtc  attcagaaa  cttcaaatt  2040
tagaaacaa  actgttcta  acgagtgac  gattatgct  tctttggcc  acattcttt  2100
ttctgcggt  aagttgagg  ttataagtt  aaacaaagg  actaactta  tgtccacca  2160
tttatacag  actcacagt  cctatgact  ttttaaact  agatctgtt  aaaaagaaa  2220
ctgtttcaa  agatgaccg  gtacaatac  gtgtggtga  aat  2263



<210> 7788
<211> 323
<212> PRT
<213> Homo sapiens
<308> P36873
<400> 7788

Met Ala Asp Leu Asp Lys Leu Asn Ile Asp Ser Ile Ile Gln Arg Leu 
  1               5                  10                  15
Leu Glu Val Arg Gly Ser Lys Pro Gly Lys Asn Val Gln Leu Gln Glu 
             20                  25                  30
Asn Glu Ile Arg Gly Leu Cys Leu Lys Ser Arg Glu Ile Phe Leu Ser 
         35                  40                  45
Gln Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp 
     50                  55                  60
Ile His Gly Gln Tyr Tyr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly 
 65                  70                  75                  80
Phe Pro Pro Glu Ser Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg 
                 85                  90                  95
Gly Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile 
             100                105                110
Lys Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala 
         115                120                125
Ser Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Tyr 
     130                135                140
Asn Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro 
 145                150                155                160
Ile Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu 
                 165                170                175
Ser Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro 
             180                185                190
Thr Asp Val Pro Asp Gln Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp 
         195                200                205
Pro Asp Lys Asp Val Leu Gly Trp Gly Glu Asn Asp Arg Gly Val Ser 
     210                215                220
Phe Thr Phe Gly Ala Glu Val Val Ala Lys Phe Leu His Lys His Asp 
 225                230                235                240
Leu Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu 
                 245                250                255
Phe Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr 
             260                265                270
Cys Gly Glu Phe Asp Asn Ala Gly Ala Met Met Ser Val Asp Glu Thr 
         275                280                285
Leu Met Cys Ser Phe Gln Ile Leu Lys Pro Ala Glu Lys Lys Lys Pro 
     290                295                300
Asn Ala Thr Arg Pro Val Thr Pro Pro Arg Gly Met Ile Thr Lys Gln 
 305                310                315                320
Ala Lys Lys 
                 325



<210> 7789
<211> 2668
<212> DNA
<213> Rattus norvegicus
<308> S78218
<400> 7789

gctgcgggg  ggagagtct  gtgcctaca  gatggcgga  ggggagctg  acgtggaca  60
cctcatcac  cgcctgctg  aggtacgag  atgtcgtcc  ggaaaaatt  tgcagatga  120
tgaagcaga  gtccgagga  tgtgtatca  gtctcgtga  atctttctt  gccagccta  180
tcttttgga  ttggaagcg  cactgaaga  ttgtggaga  attcatgga  agtatacag  240
cttactgag  ttatttgaa  atggaggtt  tccaccaga  gccaactat  ttttcttag  300
agattatgt  gacagagga  agcagtctt  ggaaaccat  tgtttgcta  tggcttaca  360
aatcaaata  ccagagaac  tctttcttc  acgaggaaa  catgagtgt  ctagcatca  420
ccgcattta  ggattctat  atgagtgca  acgaagatt  aatattaaa  tgtggaaga  480
attcactga  tgttttaat  gtctgccta  agctgctat  gttgatgag  aaatcttct  540
ctgtcatgg  ggactgtca  cagacctac  gtctatgga  cagattcgg  gaattatga  600
acccactga  gtacctgat  caggtttgc  ttgtgattt  ctgtggtcc  acccagata  660
ggatgtaca  ggctgggga  aaaatgatc  tggtgtttc  tttactttt  gagctgatg  720
agtcagtaa  tttctgaat  gtcatgatt  ggacttgat  tgtcgagcc  atcaggtgg  780
agaagatgg  tatgaattt  ttgctaaac  acaattggt  actttattt  ctgccccaa  840
ttactgcgg  gagtttgac  atgctggtg  tatgatgag  gtggatgaa  ctttgatgt  900
ttcattcca  atattgaaa  catctgaaa  gaaagctaa  taccagtat  gtgggctga  960
ttctggacg  cctgtcact  cgcctcgaa  agctaatcc  ccgaagaaa  ggtgaagac  1020
ggaattccg  aaagagaaa  catcagatt  gttaaggac  tacttcata  tatataagt  1080
tgcactgta  aaccatcca  ccattcgac  ccctttatg  tgtcacacc  ttaacttaa  1140
gagacgggt  aaggatctt  aattttttt  taatagaaa  atgtgctac  ctgtattgt  1200
ataagtata  tctgttata  tattcaaca  agttaaatc  aaattcaaa  gtatccatt  1260
aagttctat  ttctcatat  acagttttt  aagttgaaa  catcccagt  aaactagct  1320
cgttagtta  ccagatgag  gcatgaaga  ccatctgtg  aatgtggct  tagtgttgc  1380
tggttgttt  tttattttg  gcttgtttt  ttttgtttg  ttttgctag  ataatggca  1440
ctacttttc  tatttttcc  taaccattt  aaaaagtga  aatgggaag  gctttaaag  1500
cattcacca  ctattcttt  ccttcactt  tctacttaa  gaactgttg  atcttacta  1560
gaaaactta  gcctcataa  aaaaaggaa  tttagaggc  gataggttt  aaaaatata  1620
aaactattt  atccaatga  tttaatcaa  cagtttgac  gggcaaact  tgcagctga  1680
aatgactat  tcgcttttt  caaattgcc  ctgatttgg  tttgtgcac  ctaaccttt  1740
atttattga  gctctattg  gcagtagca  ttcatttaa  ataaggctc  tatagtact  1800
tccaaaatt  gttggtaat  tgattatgt  gtaccttgg  tttaggttt  aattcgcac  1860
aaacacctt  tggcatgct  aactttctg  tattatcct  acctgcatt  gttttgttt  1920
ttggggttt  tgttgttgt  tgtttgttt  tttttagat  cacagaaca  gagaatcct  1980
tttgacaag  cttggaaag  tggctcttc  ttccctctc  atgtgaagg  tgtatttaa  2040
tgaacactg  tcagtggga  attgtcagc  ctgagtatt  ggtgcttca  tgtctaata  2100
ttgccatgt  aatgttgtt  ttgactgta  ggctatgtc  ctaaagatt  ttactctgc  2160
ttttcataa  caaaggtca  gatgtgtat  gacatgctt  gtagtgaag  atagtagca  2220
taatttctg  acatgatca  gagtttatt  cagcatttc  ttccctgtt  tctcttttt  2280
aagggttag  attaacaaa  gtcaaggaa  agcaaagtc  acaaagact  taggaggtg  2340
aattaagaa  acacagatt  gtgatcttt  gatgtgaca  ttattggat  ttattctaa  2400
gtcttattg  acattgtca  atttgtaag  ttcatgggg  tggacataa  gtttatata  2460
tgcccttct  atgtgttac  atagatgtg  aaccttata  tgtctttga  aatgttaaa  2520
tgagaactc  gttaacatt  tatggattg  cacattata  tactgcaag  aacatttga  2580
tttgagcac  gtgcaaaag  tctttaaaa  gcatatgtc  ttttttcta  ttcaatttt  2640
tttaaagca  attttaaat  tagttttc  2668



<210> 7790
<211> 327
<212> PRT
<213> Rattus norvegicus
<308> AAB34335
<400> 7790

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
  1               5                  10                  15
Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
             20                  25                  30
Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
         35                  40                  45
Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
     50                  55                  60
His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
 65                  70                  75                  80
Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                 85                  90                  95
Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
             100                105                110
Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
         115                120                125
Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
     130                135                140
Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
 145                150                155                160
Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                 165                170                175
Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
             180                185                190
Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
         195                200                205
Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
     210                215                220
Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
 225                230                235                240
Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                 245                250                255
Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
             260                265                270
Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
         275                280                285
Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
     290                295                300
Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
 305                310                315                320
Ala Asn Pro Pro Lys Lys Arg 
                 325



<210> 7791
<211> 3590
<212> DNA
<213> Homo sapiens
<308> NM_002709
<400> 7791

cctgggtct  acgcggccc  gttcgaggg  gcctctctt  tttatttat  tattttccg  60
gggtgcctc  gagtgtgcg  gcgctctcg  tacccggcg  ggagggggt  gggggaggg  120
ccgggaaaa  ggggagttg  agccggggt  gaaacgccg  gtgacttgt  ggtgagaga  180
cgccgagcc  tcgccgcag  ctccgccgc  gagaagccc  tgttcccgc  gctgggaag  240
agagtctgt  ccgacaaga  ggcggacgg  gagctgaac  tggacagcc  catcacccg  300
ctgctggag  tacgaggat  tcgtccagg  aagattgtg  agatgactg  agcagaagt  360
cgaggctta  gtatcaagt  tcgggagat  tttctcagc  agcctattc  tttggaatt  420
gaagcaccg  tgaaaattt  tggagatat  catggacaa  atacagatt  actgagatt  480
tttgaatat  gaggtttcc  accagaagc  aactatctt  tcttaggag  ttatgtgga  540
agaggaaag  agtctttgg  aaccatttg  ttgctattg  cttataaaa  caaatatcc  600
gagaacttc  ttctcttaa  aggaaacca  gagtgtgct  gcatcaatc  catttatgg  660
ttctatgat  aatgcaaac  aagatttaa  attaaattg  ggaagacct  cactgattg  720
tttaactgt  tgcctatag  agccattgt  gatgagaag  tcttctgtt  tcatggagg  780
ttgtcacca  acctgcaat  tatggagca  attcggaga  ttatgagac  tactgatgt  840
cctgataca  gtttgctct  tgatttgct  tggtctgat  cagataagg  tgtgcaagg  900
tggggagaa  atgatcgtg  tgtttcctt  acttttgga  ctgatgtag  cagtaaatt  960
ctgaatcgt  atgatttag  tttgatttg  cgagctcat  aggtggtgg  agatggata  1020
gaatttttt  ctaaacgac  gttggtaac  ttattttca  ccccaaatt  ctgtggcga  1080
tttgataat  ctggtggaa  gatgagtgt  gatgaaact  tgatgtgtt  atttcagat  1140
ttgaaacca  ctgaaaaga  agctaaata  cagtatggt  gactgaatt  tggacgtcc  1200
gtcactcca  ctcgaacag  taatccgcc  aagaaaagg  gaagaaagg  attctgtaa  1260
gaaaccatc  gatttgtta  ggacatact  cataatata  aagtgtgca  tgtaaaacc  1320
tccagccat  tgacaccct  tatgatgtc  cacctttaa  ttaaggaga  gggtaaagg  1380
tcttaaatt  ttttctaat  gaaagatgt  ctacactgt  ttgtaataa  tatactctg  1440
tatagtcaa  aaagttaaa  ccaaattca  aattatcca  taaagttac  tcttcatgt  1500
tcacaattt  taaagttga  aagcatccc  gttaaacta  atgtgatag  taaaccaga  1560
gaaagcatg  tgatccatc  gtgtaatgt  gttttagtg  tgcttggtt  tttaattat  1620
ttgagcttg  tttgttttt  tttgttttc  ctagaataa  ggcaaatac  tctaatttt  1680
ttccctaaa  atttttaaa  gtgaaatat  ggaagagct  tacagacat  caccaacta  1740
tattttccc  tgtttatct  cttagatat  tgtttaatc  tactaagaa  actttcgcc  1800
cattacatt  aaaaggaat  ttagagatt  attgtttta  aaaaaaata  gcacattgt  1860
caatccagt  attttaatc  tacagtttg  ctgggcaaa  tttacagct  atagtgaat  1920
ttttgcttt  tacaggaat  gacactgat  tggatttgt  cactctaat  tttaactta  1980
tgatgctct  ttgtgcagt  gcatttcat  taagataag  ctcatatag  attacccaa  2040
tagttggta  tgtgattat  tggtacctt  gctttaggt  ttcattcgc  cggaacacc  2100
tttggcatg  ttaacttcc  ggtaacacc  tcacctgca  tggttttct  tttcttttt  2160
ctttctttt  ttttttttt  ttttttttg  gttgttgtt  gtttttaga  ccacagtac  2220
tgagaatcc  tttttgaca  gccttggaa  gctgacact  tctcttttt  ctccctcta  2280
acgaaggat  tatttaaat  aatgctggt  agtgggaca  tttgtcaac  atgggtatt  2340
ggtgcttaa  tgtctaata  tgccatgtg  atgttgtat  cgattgtaa  gcttatgtc  2400
ctaaagatt  ttattctga  tttttcata  tcaaaggtc  tatgatact  tatagacaa  2460
ctttgtagt  aagtatagt  gcaataatt  ctgtacctg  tcaagttta  tgcagcctt  2520
cttttccta  ttctttttt  taagggtta  tattaacaa  tggcaatga  tagaaaagt  2580
aacatgaag  ttttagaag  agagaactt  caggacaca  atttgtgat  ctttgactg  2640
gacactatt  gatgtgatt  taaaagctt  tattgagca  tgtcaaatt  gtaagcttc  2700
tagggatgg  catcatatc  ataatgccc  tctatatgt  ctaccatag  tgtgacatt  2760
ttgacctta  tatcgtctt  gaaaatgtt  aattgagaa  cctgttaac  tacatttta  2820
gaattggca  attgtatta  ttactgcaa  agatatttc  ttttcagca  agtgcaaaa  2880
ttctttaaa  tgcatatgt  tttttttct  attccgttt  gttttaaag  acattttaa  2940
tgtagtttt  tcatttagt  aaagttgtc  aattgatat  aagcctgac  gattttttt  3000
ttccttaca  tgagacatt  aagcacaca  tttattcac  tagatacta  gtccttgac  3060
tattgaaat  attcttttc  gaaagtatt  atgatctgc  tatgatgta  taggttagg  3120
cacaaaggt  ttatctgag  tgatttaaa  aacttcctg  ttggagtgt  taagctgag  3180
gatttctaa  aaaatttta  ttgtacact  ttagtagtc  tagtgaagc  ggtctagaa  3240
ataagcctt  ggcagggaa  aagggcaat  ttgattaat  tcagtatta  accacatta  3300
tctgtatcc  attgtctgg  ttttgtaaa  tcatccagg  caagactaa  tatgttggt  3360
aataggaat  ctttttttt  tttaaagac  aaatgtgaa  aaataatca  tacttaagc  3420
aattaatat  ggtcattaa  tttaaagga  ggaaattta  catgtttaa  aattattca  3480
gcactctta  aaccactta  acagcctcc  gtcataaaa  tgtgttctt  acaaatatt  3540
gcttggcaa  acgacttga  ataaataaa  ctttgtttc  taggagaaaa  3590



<210> 7792
<211> 327
<212> PRT
<213> Homo sapiens
<308> P37140
<400> 7792

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
  1               5                  10                  15
Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
             20                  25                  30
Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
         35                  40                  45
Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
     50                  55                  60
His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
 65                  70                  75                  80
Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                 85                  90                  95
Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
             100                105                110
Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
         115                120                125
Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
     130                135                140
Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
 145                150                155                160
Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                 165                170                175
Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
             180                185                190
Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
         195                200                205
Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
     210                215                220
Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
 225                230                235                240
Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                 245                250                255
Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
             260                265                270
Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
         275                280                285
Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
     290                295                300
Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
 305                310                315                320
Ala Asn Pro Pro Lys Lys Arg 
                 325



<210> 7793
<211> 2668
<212> DNA
<213> Rattus norvegicus
<308> S78218
<400> 7793

gctgcgggg  ggagagtct  gtgcctaca  gatggcgga  ggggagctg  acgtggaca  60
cctcatcac  cgcctgctg  aggtacgag  atgtcgtcc  ggaaaaatt  tgcagatga  120
tgaagcaga  gtccgagga  tgtgtatca  gtctcgtga  atctttctt  gccagccta  180
tcttttgga  ttggaagcg  cactgaaga  ttgtggaga  attcatgga  agtatacag  240
cttactgag  ttatttgaa  atggaggtt  tccaccaga  gccaactat  ttttcttag  300
agattatgt  gacagagga  agcagtctt  ggaaaccat  tgtttgcta  tggcttaca  360
aatcaaata  ccagagaac  tctttcttc  acgaggaaa  catgagtgt  ctagcatca  420
ccgcattta  ggattctat  atgagtgca  acgaagatt  aatattaaa  tgtggaaga  480
attcactga  tgttttaat  gtctgccta  agctgctat  gttgatgag  aaatcttct  540
ctgtcatgg  ggactgtca  cagacctac  gtctatgga  cagattcgg  gaattatga  600
acccactga  gtacctgat  caggtttgc  ttgtgattt  ctgtggtcc  acccagata  660
ggatgtaca  ggctgggga  aaaatgatc  tggtgtttc  tttactttt  gagctgatg  720
agtcagtaa  tttctgaat  gtcatgatt  ggacttgat  tgtcgagcc  atcaggtgg  780
agaagatgg  tatgaattt  ttgctaaac  acaattggt  actttattt  ctgccccaa  840
ttactgcgg  gagtttgac  atgctggtg  tatgatgag  gtggatgaa  ctttgatgt  900
ttcattcca  atattgaaa  catctgaaa  gaaagctaa  taccagtat  gtgggctga  960
ttctggacg  cctgtcact  cgcctcgaa  agctaatcc  ccgaagaaa  ggtgaagac  1020
ggaattccg  aaagagaaa  catcagatt  gttaaggac  tacttcata  tatataagt  1080
tgcactgta  aaccatcca  ccattcgac  ccctttatg  tgtcacacc  ttaacttaa  1140
gagacgggt  aaggatctt  aattttttt  taatagaaa  atgtgctac  ctgtattgt  1200
ataagtata  tctgttata  tattcaaca  agttaaatc  aaattcaaa  gtatccatt  1260
aagttctat  ttctcatat  acagttttt  aagttgaaa  catcccagt  aaactagct  1320
cgttagtta  ccagatgag  gcatgaaga  ccatctgtg  aatgtggct  tagtgttgc  1380
tggttgttt  tttattttg  gcttgtttt  ttttgtttg  ttttgctag  ataatggca  1440
ctacttttc  tatttttcc  taaccattt  aaaaagtga  aatgggaag  gctttaaag  1500
cattcacca  ctattcttt  ccttcactt  tctacttaa  gaactgttg  atcttacta  1560
gaaaactta  gcctcataa  aaaaaggaa  tttagaggc  gataggttt  aaaaatata  1620
aaactattt  atccaatga  tttaatcaa  cagtttgac  gggcaaact  tgcagctga  1680
aatgactat  tcgcttttt  caaattgcc  ctgatttgg  tttgtgcac  ctaaccttt  1740
atttattga  gctctattg  gcagtagca  ttcatttaa  ataaggctc  tatagtact  1800
tccaaaatt  gttggtaat  tgattatgt  gtaccttgg  tttaggttt  aattcgcac  1860
aaacacctt  tggcatgct  aactttctg  tattatcct  acctgcatt  gttttgttt  1920
ttggggttt  tgttgttgt  tgtttgttt  tttttagat  cacagaaca  gagaatcct  1980
tttgacaag  cttggaaag  tggctcttc  ttccctctc  atgtgaagg  tgtatttaa  2040
tgaacactg  tcagtggga  attgtcagc  ctgagtatt  ggtgcttca  tgtctaata  2100
ttgccatgt  aatgttgtt  ttgactgta  ggctatgtc  ctaaagatt  ttactctgc  2160
ttttcataa  caaaggtca  gatgtgtat  gacatgctt  gtagtgaag  atagtagca  2220
taatttctg  acatgatca  gagtttatt  cagcatttc  ttccctgtt  tctcttttt  2280
aagggttag  attaacaaa  gtcaaggaa  agcaaagtc  acaaagact  taggaggtg  2340
aattaagaa  acacagatt  gtgatcttt  gatgtgaca  ttattggat  ttattctaa  2400
gtcttattg  acattgtca  atttgtaag  ttcatgggg  tggacataa  gtttatata  2460
tgcccttct  atgtgttac  atagatgtg  aaccttata  tgtctttga  aatgttaaa  2520
tgagaactc  gttaacatt  tatggattg  cacattata  tactgcaag  aacatttga  2580
tttgagcac  gtgcaaaag  tctttaaaa  gcatatgtc  ttttttcta  ttcaatttt  2640
tttaaagca  attttaaat  tagttttc  2668



<210> 7794
<211> 327
<212> PRT
<213> Rattus norvegicus
<308> AAB34335
<400> 7794

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
  1               5                  10                  15
Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
             20                  25                  30
Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
         35                  40                  45
Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
     50                  55                  60
His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
 65                  70                  75                  80
Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                 85                  90                  95
Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
             100                105                110
Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
         115                120                125
Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
     130                135                140
Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
 145                150                155                160
Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                 165                170                175
Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
             180                185                190
Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
         195                200                205
Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
     210                215                220
Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
 225                230                235                240
Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                 245                250                255
Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
             260                265                270
Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
         275                280                285
Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
     290                295                300
Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
 305                310                315                320
Ala Asn Pro Pro Lys Lys Arg 
                 325



<210> 7795
<211> 3590
<212> DNA
<213> Homo sapiens
<308> NM_002709
<400> 7795

cctgggtct  acgcggccc  gttcgaggg  gcctctctt  tttatttat  tattttccg  60
gggtgcctc  gagtgtgcg  gcgctctcg  tacccggcg  ggagggggt  gggggaggg  120
ccgggaaaa  ggggagttg  agccggggt  gaaacgccg  gtgacttgt  ggtgagaga  180
cgccgagcc  tcgccgcag  ctccgccgc  gagaagccc  tgttcccgc  gctgggaag  240
agagtctgt  ccgacaaga  ggcggacgg  gagctgaac  tggacagcc  catcacccg  300
ctgctggag  tacgaggat  tcgtccagg  aagattgtg  agatgactg  agcagaagt  360
cgaggctta  gtatcaagt  tcgggagat  tttctcagc  agcctattc  tttggaatt  420
gaagcaccg  tgaaaattt  tggagatat  catggacaa  atacagatt  actgagatt  480
tttgaatat  gaggtttcc  accagaagc  aactatctt  tcttaggag  ttatgtgga  540
agaggaaag  agtctttgg  aaccatttg  ttgctattg  cttataaaa  caaatatcc  600
gagaacttc  ttctcttaa  aggaaacca  gagtgtgct  gcatcaatc  catttatgg  660
ttctatgat  aatgcaaac  aagatttaa  attaaattg  ggaagacct  cactgattg  720
tttaactgt  tgcctatag  agccattgt  gatgagaag  tcttctgtt  tcatggagg  780
ttgtcacca  acctgcaat  tatggagca  attcggaga  ttatgagac  tactgatgt  840
cctgataca  gtttgctct  tgatttgct  tggtctgat  cagataagg  tgtgcaagg  900
tggggagaa  atgatcgtg  tgtttcctt  acttttgga  ctgatgtag  cagtaaatt  960
ctgaatcgt  atgatttag  tttgatttg  cgagctcat  aggtggtgg  agatggata  1020
gaatttttt  ctaaacgac  gttggtaac  ttattttca  ccccaaatt  ctgtggcga  1080
tttgataat  ctggtggaa  gatgagtgt  gatgaaact  tgatgtgtt  atttcagat  1140
ttgaaacca  ctgaaaaga  agctaaata  cagtatggt  gactgaatt  tggacgtcc  1200
gtcactcca  ctcgaacag  taatccgcc  aagaaaagg  gaagaaagg  attctgtaa  1260
gaaaccatc  gatttgtta  ggacatact  cataatata  aagtgtgca  tgtaaaacc  1320
tccagccat  tgacaccct  tatgatgtc  cacctttaa  ttaaggaga  gggtaaagg  1380
tcttaaatt  ttttctaat  gaaagatgt  ctacactgt  ttgtaataa  tatactctg  1440
tatagtcaa  aaagttaaa  ccaaattca  aattatcca  taaagttac  tcttcatgt  1500
tcacaattt  taaagttga  aagcatccc  gttaaacta  atgtgatag  taaaccaga  1560
gaaagcatg  tgatccatc  gtgtaatgt  gttttagtg  tgcttggtt  tttaattat  1620
ttgagcttg  tttgttttt  tttgttttc  ctagaataa  ggcaaatac  tctaatttt  1680
ttccctaaa  atttttaaa  gtgaaatat  ggaagagct  tacagacat  caccaacta  1740
tattttccc  tgtttatct  cttagatat  tgtttaatc  tactaagaa  actttcgcc  1800
cattacatt  aaaaggaat  ttagagatt  attgtttta  aaaaaaata  gcacattgt  1860
caatccagt  attttaatc  tacagtttg  ctgggcaaa  tttacagct  atagtgaat  1920
ttttgcttt  tacaggaat  gacactgat  tggatttgt  cactctaat  tttaactta  1980
tgatgctct  ttgtgcagt  gcatttcat  taagataag  ctcatatag  attacccaa  2040
tagttggta  tgtgattat  tggtacctt  gctttaggt  ttcattcgc  cggaacacc  2100
tttggcatg  ttaacttcc  ggtaacacc  tcacctgca  tggttttct  tttcttttt  2160
ctttctttt  ttttttttt  ttttttttg  gttgttgtt  gtttttaga  ccacagtac  2220
tgagaatcc  tttttgaca  gccttggaa  gctgacact  tctcttttt  ctccctcta  2280
acgaaggat  tatttaaat  aatgctggt  agtgggaca  tttgtcaac  atgggtatt  2340
ggtgcttaa  tgtctaata  tgccatgtg  atgttgtat  cgattgtaa  gcttatgtc  2400
ctaaagatt  ttattctga  tttttcata  tcaaaggtc  tatgatact  tatagacaa  2460
ctttgtagt  aagtatagt  gcaataatt  ctgtacctg  tcaagttta  tgcagcctt  2520
cttttccta  ttctttttt  taagggtta  tattaacaa  tggcaatga  tagaaaagt  2580
aacatgaag  ttttagaag  agagaactt  caggacaca  atttgtgat  ctttgactg  2640
gacactatt  gatgtgatt  taaaagctt  tattgagca  tgtcaaatt  gtaagcttc  2700
tagggatgg  catcatatc  ataatgccc  tctatatgt  ctaccatag  tgtgacatt  2760
ttgacctta  tatcgtctt  gaaaatgtt  aattgagaa  cctgttaac  tacatttta  2820
gaattggca  attgtatta  ttactgcaa  agatatttc  ttttcagca  agtgcaaaa  2880
ttctttaaa  tgcatatgt  tttttttct  attccgttt  gttttaaag  acattttaa  2940
tgtagtttt  tcatttagt  aaagttgtc  aattgatat  aagcctgac  gattttttt  3000
ttccttaca  tgagacatt  aagcacaca  tttattcac  tagatacta  gtccttgac  3060
tattgaaat  attcttttc  gaaagtatt  atgatctgc  tatgatgta  taggttagg  3120
cacaaaggt  ttatctgag  tgatttaaa  aacttcctg  ttggagtgt  taagctgag  3180
gatttctaa  aaaatttta  ttgtacact  ttagtagtc  tagtgaagc  ggtctagaa  3240
ataagcctt  ggcagggaa  aagggcaat  ttgattaat  tcagtatta  accacatta  3300
tctgtatcc  attgtctgg  ttttgtaaa  tcatccagg  caagactaa  tatgttggt  3360
aataggaat  ctttttttt  tttaaagac  aaatgtgaa  aaataatca  tacttaagc  3420
aattaatat  ggtcattaa  tttaaagga  ggaaattta  catgtttaa  aattattca  3480
gcactctta  aaccactta  acagcctcc  gtcataaaa  tgtgttctt  acaaatatt  3540
gcttggcaa  acgacttga  ataaataaa  ctttgtttc  taggagaaaa  3590



<210> 7796
<211> 327
<212> PRT
<213> Homo sapiens
<308> P37140
<400> 7796

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
  1               5                  10                  15
Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
             20                  25                  30
Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
         35                  40                  45
Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
     50                  55                  60
His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
 65                  70                  75                  80
Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                 85                  90                  95
Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
             100                105                110
Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
         115                120                125
Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
     130                135                140
Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
 145                150                155                160
Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                 165                170                175
Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
             180                185                190
Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
         195                200                205
Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
     210                215                220
Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
 225                230                235                240
Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                 245                250                255
Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
             260                265                270
Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
         275                280                285
Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
     290                295                300
Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
 305                310                315                320
Ala Asn Pro Pro Lys Lys Arg 
                 325



<210> 7797
<211> 2668
<212> DNA
<213> Rattus norvegicus
<308> S78218
<400> 7797

gctgcgggg  ggagagtct  gtgcctaca  gatggcgga  ggggagctg  acgtggaca  60
cctcatcac  cgcctgctg  aggtacgag  atgtcgtcc  ggaaaaatt  tgcagatga  120
tgaagcaga  gtccgagga  tgtgtatca  gtctcgtga  atctttctt  gccagccta  180
tcttttgga  ttggaagcg  cactgaaga  ttgtggaga  attcatgga  agtatacag  240
cttactgag  ttatttgaa  atggaggtt  tccaccaga  gccaactat  ttttcttag  300
agattatgt  gacagagga  agcagtctt  ggaaaccat  tgtttgcta  tggcttaca  360
aatcaaata  ccagagaac  tctttcttc  acgaggaaa  catgagtgt  ctagcatca  420
ccgcattta  ggattctat  atgagtgca  acgaagatt  aatattaaa  tgtggaaga  480
attcactga  tgttttaat  gtctgccta  agctgctat  gttgatgag  aaatcttct  540
ctgtcatgg  ggactgtca  cagacctac  gtctatgga  cagattcgg  gaattatga  600
acccactga  gtacctgat  caggtttgc  ttgtgattt  ctgtggtcc  acccagata  660
ggatgtaca  ggctgggga  aaaatgatc  tggtgtttc  tttactttt  gagctgatg  720
agtcagtaa  tttctgaat  gtcatgatt  ggacttgat  tgtcgagcc  atcaggtgg  780
agaagatgg  tatgaattt  ttgctaaac  acaattggt  actttattt  ctgccccaa  840
ttactgcgg  gagtttgac  atgctggtg  tatgatgag  gtggatgaa  ctttgatgt  900
ttcattcca  atattgaaa  catctgaaa  gaaagctaa  taccagtat  gtgggctga  960
ttctggacg  cctgtcact  cgcctcgaa  agctaatcc  ccgaagaaa  ggtgaagac  1020
ggaattccg  aaagagaaa  catcagatt  gttaaggac  tacttcata  tatataagt  1080
tgcactgta  aaccatcca  ccattcgac  ccctttatg  tgtcacacc  ttaacttaa  1140
gagacgggt  aaggatctt  aattttttt  taatagaaa  atgtgctac  ctgtattgt  1200
ataagtata  tctgttata  tattcaaca  agttaaatc  aaattcaaa  gtatccatt  1260
aagttctat  ttctcatat  acagttttt  aagttgaaa  catcccagt  aaactagct  1320
cgttagtta  ccagatgag  gcatgaaga  ccatctgtg  aatgtggct  tagtgttgc  1380
tggttgttt  tttattttg  gcttgtttt  ttttgtttg  ttttgctag  ataatggca  1440
ctacttttc  tatttttcc  taaccattt  aaaaagtga  aatgggaag  gctttaaag  1500
cattcacca  ctattcttt  ccttcactt  tctacttaa  gaactgttg  atcttacta  1560
gaaaactta  gcctcataa  aaaaaggaa  tttagaggc  gataggttt  aaaaatata  1620
aaactattt  atccaatga  tttaatcaa  cagtttgac  gggcaaact  tgcagctga  1680
aatgactat  tcgcttttt  caaattgcc  ctgatttgg  tttgtgcac  ctaaccttt  1740
atttattga  gctctattg  gcagtagca  ttcatttaa  ataaggctc  tatagtact  1800
tccaaaatt  gttggtaat  tgattatgt  gtaccttgg  tttaggttt  aattcgcac  1860
aaacacctt  tggcatgct  aactttctg  tattatcct  acctgcatt  gttttgttt  1920
ttggggttt  tgttgttgt  tgtttgttt  tttttagat  cacagaaca  gagaatcct  1980
tttgacaag  cttggaaag  tggctcttc  ttccctctc  atgtgaagg  tgtatttaa  2040
tgaacactg  tcagtggga  attgtcagc  ctgagtatt  ggtgcttca  tgtctaata  2100
ttgccatgt  aatgttgtt  ttgactgta  ggctatgtc  ctaaagatt  ttactctgc  2160
ttttcataa  caaaggtca  gatgtgtat  gacatgctt  gtagtgaag  atagtagca  2220
taatttctg  acatgatca  gagtttatt  cagcatttc  ttccctgtt  tctcttttt  2280
aagggttag  attaacaaa  gtcaaggaa  agcaaagtc  acaaagact  taggaggtg  2340
aattaagaa  acacagatt  gtgatcttt  gatgtgaca  ttattggat  ttattctaa  2400
gtcttattg  acattgtca  atttgtaag  ttcatgggg  tggacataa  gtttatata  2460
tgcccttct  atgtgttac  atagatgtg  aaccttata  tgtctttga  aatgttaaa  2520
tgagaactc  gttaacatt  tatggattg  cacattata  tactgcaag  aacatttga  2580
tttgagcac  gtgcaaaag  tctttaaaa  gcatatgtc  ttttttcta  ttcaatttt  2640
tttaaagca  attttaaat  tagttttc  2668



<210> 7798
<211> 327
<212> PRT
<213> Rattus norvegicus
<308> AAB34335
<400> 7798

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
  1               5                  10                  15
Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
             20                  25                  30
Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
         35                  40                  45
Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
     50                  55                  60
His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
 65                  70                  75                  80
Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                 85                  90                  95
Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
             100                105                110
Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
         115                120                125
Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
     130                135                140
Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
 145                150                155                160
Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                 165                170                175
Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
             180                185                190
Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
         195                200                205
Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
     210                215                220
Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
 225                230                235                240
Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                 245                250                255
Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
             260                265                270
Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
         275                280                285
Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
     290                295                300
Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
 305                310                315                320
Ala Asn Pro Pro Lys Lys Arg 
                 325



<210> 7799
<211> 3590
<212> DNA
<213> Homo sapiens
<308> NM_002709
<400> 7799

cctgggtct  acgcggccc  gttcgaggg  gcctctctt  tttatttat  tattttccg  60
gggtgcctc  gagtgtgcg  gcgctctcg  tacccggcg  ggagggggt  gggggaggg  120
ccgggaaaa  ggggagttg  agccggggt  gaaacgccg  gtgacttgt  ggtgagaga  180
cgccgagcc  tcgccgcag  ctccgccgc  gagaagccc  tgttcccgc  gctgggaag  240
agagtctgt  ccgacaaga  ggcggacgg  gagctgaac  tggacagcc  catcacccg  300
ctgctggag  tacgaggat  tcgtccagg  aagattgtg  agatgactg  agcagaagt  360
cgaggctta  gtatcaagt  tcgggagat  tttctcagc  agcctattc  tttggaatt  420
gaagcaccg  tgaaaattt  tggagatat  catggacaa  atacagatt  actgagatt  480
tttgaatat  gaggtttcc  accagaagc  aactatctt  tcttaggag  ttatgtgga  540
agaggaaag  agtctttgg  aaccatttg  ttgctattg  cttataaaa  caaatatcc  600
gagaacttc  ttctcttaa  aggaaacca  gagtgtgct  gcatcaatc  catttatgg  660
ttctatgat  aatgcaaac  aagatttaa  attaaattg  ggaagacct  cactgattg  720
tttaactgt  tgcctatag  agccattgt  gatgagaag  tcttctgtt  tcatggagg  780
ttgtcacca  acctgcaat  tatggagca  attcggaga  ttatgagac  tactgatgt  840
cctgataca  gtttgctct  tgatttgct  tggtctgat  cagataagg  tgtgcaagg  900
tggggagaa  atgatcgtg  tgtttcctt  acttttgga  ctgatgtag  cagtaaatt  960
ctgaatcgt  atgatttag  tttgatttg  cgagctcat  aggtggtgg  agatggata  1020
gaatttttt  ctaaacgac  gttggtaac  ttattttca  ccccaaatt  ctgtggcga  1080
tttgataat  ctggtggaa  gatgagtgt  gatgaaact  tgatgtgtt  atttcagat  1140
ttgaaacca  ctgaaaaga  agctaaata  cagtatggt  gactgaatt  tggacgtcc  1200
gtcactcca  ctcgaacag  taatccgcc  aagaaaagg  gaagaaagg  attctgtaa  1260
gaaaccatc  gatttgtta  ggacatact  cataatata  aagtgtgca  tgtaaaacc  1320
tccagccat  tgacaccct  tatgatgtc  cacctttaa  ttaaggaga  gggtaaagg  1380
tcttaaatt  ttttctaat  gaaagatgt  ctacactgt  ttgtaataa  tatactctg  1440
tatagtcaa  aaagttaaa  ccaaattca  aattatcca  taaagttac  tcttcatgt  1500
tcacaattt  taaagttga  aagcatccc  gttaaacta  atgtgatag  taaaccaga  1560
gaaagcatg  tgatccatc  gtgtaatgt  gttttagtg  tgcttggtt  tttaattat  1620
ttgagcttg  tttgttttt  tttgttttc  ctagaataa  ggcaaatac  tctaatttt  1680
ttccctaaa  atttttaaa  gtgaaatat  ggaagagct  tacagacat  caccaacta  1740
tattttccc  tgtttatct  cttagatat  tgtttaatc  tactaagaa  actttcgcc  1800
cattacatt  aaaaggaat  ttagagatt  attgtttta  aaaaaaata  gcacattgt  1860
caatccagt  attttaatc  tacagtttg  ctgggcaaa  tttacagct  atagtgaat  1920
ttttgcttt  tacaggaat  gacactgat  tggatttgt  cactctaat  tttaactta  1980
tgatgctct  ttgtgcagt  gcatttcat  taagataag  ctcatatag  attacccaa  2040
tagttggta  tgtgattat  tggtacctt  gctttaggt  ttcattcgc  cggaacacc  2100
tttggcatg  ttaacttcc  ggtaacacc  tcacctgca  tggttttct  tttcttttt  2160
ctttctttt  ttttttttt  ttttttttg  gttgttgtt  gtttttaga  ccacagtac  2220
tgagaatcc  tttttgaca  gccttggaa  gctgacact  tctcttttt  ctccctcta  2280
acgaaggat  tatttaaat  aatgctggt  agtgggaca  tttgtcaac  atgggtatt  2340
ggtgcttaa  tgtctaata  tgccatgtg  atgttgtat  cgattgtaa  gcttatgtc  2400
ctaaagatt  ttattctga  tttttcata  tcaaaggtc  tatgatact  tatagacaa  2460
ctttgtagt  aagtatagt  gcaataatt  ctgtacctg  tcaagttta  tgcagcctt  2520
cttttccta  ttctttttt  taagggtta  tattaacaa  tggcaatga  tagaaaagt  2580
aacatgaag  ttttagaag  agagaactt  caggacaca  atttgtgat  ctttgactg  2640
gacactatt  gatgtgatt  taaaagctt  tattgagca  tgtcaaatt  gtaagcttc  2700
tagggatgg  catcatatc  ataatgccc  tctatatgt  ctaccatag  tgtgacatt  2760
ttgacctta  tatcgtctt  gaaaatgtt  aattgagaa  cctgttaac  tacatttta  2820
gaattggca  attgtatta  ttactgcaa  agatatttc  ttttcagca  agtgcaaaa  2880
ttctttaaa  tgcatatgt  tttttttct  attccgttt  gttttaaag  acattttaa  2940
tgtagtttt  tcatttagt  aaagttgtc  aattgatat  aagcctgac  gattttttt  3000
ttccttaca  tgagacatt  aagcacaca  tttattcac  tagatacta  gtccttgac  3060
tattgaaat  attcttttc  gaaagtatt  atgatctgc  tatgatgta  taggttagg  3120
cacaaaggt  ttatctgag  tgatttaaa  aacttcctg  ttggagtgt  taagctgag  3180
gatttctaa  aaaatttta  ttgtacact  ttagtagtc  tagtgaagc  ggtctagaa  3240
ataagcctt  ggcagggaa  aagggcaat  ttgattaat  tcagtatta  accacatta  3300
tctgtatcc  attgtctgg  ttttgtaaa  tcatccagg  caagactaa  tatgttggt  3360
aataggaat  ctttttttt  tttaaagac  aaatgtgaa  aaataatca  tacttaagc  3420
aattaatat  ggtcattaa  tttaaagga  ggaaattta  catgtttaa  aattattca  3480
gcactctta  aaccactta  acagcctcc  gtcataaaa  tgtgttctt  acaaatatt  3540
gcttggcaa  acgacttga  ataaataaa  ctttgtttc  taggagaaaa  3590



<210> 7800
<211> 327
<212> PRT
<213> Homo sapiens
<308> P37140
<400> 7800

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
  1               5                  10                  15
Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
             20                  25                  30
Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
         35                  40                  45
Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
     50                  55                  60
His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
 65                  70                  75                  80
Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                 85                  90                  95
Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
             100                105                110
Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
         115                120                125
Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
     130                135                140
Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
 145                150                155                160
Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                 165                170                175
Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
             180                185                190
Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
         195                200                205
Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
     210                215                220
Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
 225                230                235                240
Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                 245                250                255
Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
             260                265                270
Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
         275                280                285
Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
     290                295                300
Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
 305                310                315                320
Ala Asn Pro Pro Lys Lys Arg 
                 325



<210> 7801
<211> 2668
<212> DNA
<213> Rattus norvegicus
<308> S78218
<400> 7801

gctgcgggg  ggagagtct  gtgcctaca  gatggcgga  ggggagctg  acgtggaca  60
cctcatcac  cgcctgctg  aggtacgag  atgtcgtcc  ggaaaaatt  tgcagatga  120
tgaagcaga  gtccgagga  tgtgtatca  gtctcgtga  atctttctt  gccagccta  180
tcttttgga  ttggaagcg  cactgaaga  ttgtggaga  attcatgga  agtatacag  240
cttactgag  ttatttgaa  atggaggtt  tccaccaga  gccaactat  ttttcttag  300
agattatgt  gacagagga  agcagtctt  ggaaaccat  tgtttgcta  tggcttaca  360
aatcaaata  ccagagaac  tctttcttc  acgaggaaa  catgagtgt  ctagcatca  420
ccgcattta  ggattctat  atgagtgca  acgaagatt  aatattaaa  tgtggaaga  480
attcactga  tgttttaat  gtctgccta  agctgctat  gttgatgag  aaatcttct  540
ctgtcatgg  ggactgtca  cagacctac  gtctatgga  cagattcgg  gaattatga  600
acccactga  gtacctgat  caggtttgc  ttgtgattt  ctgtggtcc  acccagata  660
ggatgtaca  ggctgggga  aaaatgatc  tggtgtttc  tttactttt  gagctgatg  720
agtcagtaa  tttctgaat  gtcatgatt  ggacttgat  tgtcgagcc  atcaggtgg  780
agaagatgg  tatgaattt  ttgctaaac  acaattggt  actttattt  ctgccccaa  840
ttactgcgg  gagtttgac  atgctggtg  tatgatgag  gtggatgaa  ctttgatgt  900
ttcattcca  atattgaaa  catctgaaa  gaaagctaa  taccagtat  gtgggctga  960
ttctggacg  cctgtcact  cgcctcgaa  agctaatcc  ccgaagaaa  ggtgaagac  1020
ggaattccg  aaagagaaa  catcagatt  gttaaggac  tacttcata  tatataagt  1080
tgcactgta  aaccatcca  ccattcgac  ccctttatg  tgtcacacc  ttaacttaa  1140
gagacgggt  aaggatctt  aattttttt  taatagaaa  atgtgctac  ctgtattgt  1200
ataagtata  tctgttata  tattcaaca  agttaaatc  aaattcaaa  gtatccatt  1260
aagttctat  ttctcatat  acagttttt  aagttgaaa  catcccagt  aaactagct  1320
cgttagtta  ccagatgag  gcatgaaga  ccatctgtg  aatgtggct  tagtgttgc  1380
tggttgttt  tttattttg  gcttgtttt  ttttgtttg  ttttgctag  ataatggca  1440
ctacttttc  tatttttcc  taaccattt  aaaaagtga  aatgggaag  gctttaaag  1500
cattcacca  ctattcttt  ccttcactt  tctacttaa  gaactgttg  atcttacta  1560
gaaaactta  gcctcataa  aaaaaggaa  tttagaggc  gataggttt  aaaaatata  1620
aaactattt  atccaatga  tttaatcaa  cagtttgac  gggcaaact  tgcagctga  1680
aatgactat  tcgcttttt  caaattgcc  ctgatttgg  tttgtgcac  ctaaccttt  1740
atttattga  gctctattg  gcagtagca  ttcatttaa  ataaggctc  tatagtact  1800
tccaaaatt  gttggtaat  tgattatgt  gtaccttgg  tttaggttt  aattcgcac  1860
aaacacctt  tggcatgct  aactttctg  tattatcct  acctgcatt  gttttgttt  1920
ttggggttt  tgttgttgt  tgtttgttt  tttttagat  cacagaaca  gagaatcct  1980
tttgacaag  cttggaaag  tggctcttc  ttccctctc  atgtgaagg  tgtatttaa  2040
tgaacactg  tcagtggga  attgtcagc  ctgagtatt  ggtgcttca  tgtctaata  2100
ttgccatgt  aatgttgtt  ttgactgta  ggctatgtc  ctaaagatt  ttactctgc  2160
ttttcataa  caaaggtca  gatgtgtat  gacatgctt  gtagtgaag  atagtagca  2220
taatttctg  acatgatca  gagtttatt  cagcatttc  ttccctgtt  tctcttttt  2280
aagggttag  attaacaaa  gtcaaggaa  agcaaagtc  acaaagact  taggaggtg  2340
aattaagaa  acacagatt  gtgatcttt  gatgtgaca  ttattggat  ttattctaa  2400
gtcttattg  acattgtca  atttgtaag  ttcatgggg  tggacataa  gtttatata  2460
tgcccttct  atgtgttac  atagatgtg  aaccttata  tgtctttga  aatgttaaa  2520
tgagaactc  gttaacatt  tatggattg  cacattata  tactgcaag  aacatttga  2580
tttgagcac  gtgcaaaag  tctttaaaa  gcatatgtc  ttttttcta  ttcaatttt  2640
tttaaagca  attttaaat  tagttttc  2668



<210> 7802
<211> 327
<212> PRT
<213> Rattus norvegicus
<308> AAB34335
<400> 7802

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
  1               5                  10                  15
Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
             20                  25                  30
Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
         35                  40                  45
Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
     50                  55                  60
His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
 65                  70                  75                  80
Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                 85                  90                  95
Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
             100                105                110
Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
         115                120                125
Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
     130                135                140
Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
 145                150                155                160
Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                 165                170                175
Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
             180                185                190
Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
         195                200                205
Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
     210                215                220
Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
 225                230                235                240
Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                 245                250                255
Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
             260                265                270
Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
         275                280                285
Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
     290                295                300
Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
 305                310                315                320
Ala Asn Pro Pro Lys Lys Arg 
                 325



<210> 7803
<211> 3590
<212> DNA
<213> Homo sapiens
<308> NM_002709
<400> 7803

cctgggtct  acgcggccc  gttcgaggg  gcctctctt  tttatttat  tattttccg  60
gggtgcctc  gagtgtgcg  gcgctctcg  tacccggcg  ggagggggt  gggggaggg  120
ccgggaaaa  ggggagttg  agccggggt  gaaacgccg  gtgacttgt  ggtgagaga  180
cgccgagcc  tcgccgcag  ctccgccgc  gagaagccc  tgttcccgc  gctgggaag  240
agagtctgt  ccgacaaga  ggcggacgg  gagctgaac  tggacagcc  catcacccg  300
ctgctggag  tacgaggat  tcgtccagg  aagattgtg  agatgactg  agcagaagt  360
cgaggctta  gtatcaagt  tcgggagat  tttctcagc  agcctattc  tttggaatt  420
gaagcaccg  tgaaaattt  tggagatat  catggacaa  atacagatt  actgagatt  480
tttgaatat  gaggtttcc  accagaagc  aactatctt  tcttaggag  ttatgtgga  540
agaggaaag  agtctttgg  aaccatttg  ttgctattg  cttataaaa  caaatatcc  600
gagaacttc  ttctcttaa  aggaaacca  gagtgtgct  gcatcaatc  catttatgg  660
ttctatgat  aatgcaaac  aagatttaa  attaaattg  ggaagacct  cactgattg  720
tttaactgt  tgcctatag  agccattgt  gatgagaag  tcttctgtt  tcatggagg  780
ttgtcacca  acctgcaat  tatggagca  attcggaga  ttatgagac  tactgatgt  840
cctgataca  gtttgctct  tgatttgct  tggtctgat  cagataagg  tgtgcaagg  900
tggggagaa  atgatcgtg  tgtttcctt  acttttgga  ctgatgtag  cagtaaatt  960
ctgaatcgt  atgatttag  tttgatttg  cgagctcat  aggtggtgg  agatggata  1020
gaatttttt  ctaaacgac  gttggtaac  ttattttca  ccccaaatt  ctgtggcga  1080
tttgataat  ctggtggaa  gatgagtgt  gatgaaact  tgatgtgtt  atttcagat  1140
ttgaaacca  ctgaaaaga  agctaaata  cagtatggt  gactgaatt  tggacgtcc  1200
gtcactcca  ctcgaacag  taatccgcc  aagaaaagg  gaagaaagg  attctgtaa  1260
gaaaccatc  gatttgtta  ggacatact  cataatata  aagtgtgca  tgtaaaacc  1320
tccagccat  tgacaccct  tatgatgtc  cacctttaa  ttaaggaga  gggtaaagg  1380
tcttaaatt  ttttctaat  gaaagatgt  ctacactgt  ttgtaataa  tatactctg  1440
tatagtcaa  aaagttaaa  ccaaattca  aattatcca  taaagttac  tcttcatgt  1500
tcacaattt  taaagttga  aagcatccc  gttaaacta  atgtgatag  taaaccaga  1560
gaaagcatg  tgatccatc  gtgtaatgt  gttttagtg  tgcttggtt  tttaattat  1620
ttgagcttg  tttgttttt  tttgttttc  ctagaataa  ggcaaatac  tctaatttt  1680
ttccctaaa  atttttaaa  gtgaaatat  ggaagagct  tacagacat  caccaacta  1740
tattttccc  tgtttatct  cttagatat  tgtttaatc  tactaagaa  actttcgcc  1800
cattacatt  aaaaggaat  ttagagatt  attgtttta  aaaaaaata  gcacattgt  1860
caatccagt  attttaatc  tacagtttg  ctgggcaaa  tttacagct  atagtgaat  1920
ttttgcttt  tacaggaat  gacactgat  tggatttgt  cactctaat  tttaactta  1980
tgatgctct  ttgtgcagt  gcatttcat  taagataag  ctcatatag  attacccaa  2040
tagttggta  tgtgattat  tggtacctt  gctttaggt  ttcattcgc  cggaacacc  2100
tttggcatg  ttaacttcc  ggtaacacc  tcacctgca  tggttttct  tttcttttt  2160
ctttctttt  ttttttttt  ttttttttg  gttgttgtt  gtttttaga  ccacagtac  2220
tgagaatcc  tttttgaca  gccttggaa  gctgacact  tctcttttt  ctccctcta  2280
acgaaggat  tatttaaat  aatgctggt  agtgggaca  tttgtcaac  atgggtatt  2340
ggtgcttaa  tgtctaata  tgccatgtg  atgttgtat  cgattgtaa  gcttatgtc  2400
ctaaagatt  ttattctga  tttttcata  tcaaaggtc  tatgatact  tatagacaa  2460
ctttgtagt  aagtatagt  gcaataatt  ctgtacctg  tcaagttta  tgcagcctt  2520
cttttccta  ttctttttt  taagggtta  tattaacaa  tggcaatga  tagaaaagt  2580
aacatgaag  ttttagaag  agagaactt  caggacaca  atttgtgat  ctttgactg  2640
gacactatt  gatgtgatt  taaaagctt  tattgagca  tgtcaaatt  gtaagcttc  2700
tagggatgg  catcatatc  ataatgccc  tctatatgt  ctaccatag  tgtgacatt  2760
ttgacctta  tatcgtctt  gaaaatgtt  aattgagaa  cctgttaac  tacatttta  2820
gaattggca  attgtatta  ttactgcaa  agatatttc  ttttcagca  agtgcaaaa  2880
ttctttaaa  tgcatatgt  tttttttct  attccgttt  gttttaaag  acattttaa  2940
tgtagtttt  tcatttagt  aaagttgtc  aattgatat  aagcctgac  gattttttt  3000
ttccttaca  tgagacatt  aagcacaca  tttattcac  tagatacta  gtccttgac  3060
tattgaaat  attcttttc  gaaagtatt  atgatctgc  tatgatgta  taggttagg  3120
cacaaaggt  ttatctgag  tgatttaaa  aacttcctg  ttggagtgt  taagctgag  3180
gatttctaa  aaaatttta  ttgtacact  ttagtagtc  tagtgaagc  ggtctagaa  3240
ataagcctt  ggcagggaa  aagggcaat  ttgattaat  tcagtatta  accacatta  3300
tctgtatcc  attgtctgg  ttttgtaaa  tcatccagg  caagactaa  tatgttggt  3360
aataggaat  ctttttttt  tttaaagac  aaatgtgaa  aaataatca  tacttaagc  3420
aattaatat  ggtcattaa  tttaaagga  ggaaattta  catgtttaa  aattattca  3480
gcactctta  aaccactta  acagcctcc  gtcataaaa  tgtgttctt  acaaatatt  3540
gcttggcaa  acgacttga  ataaataaa  ctttgtttc  taggagaaaa  3590



<210> 7804
<211> 327
<212> PRT
<213> Homo sapiens
<308> P37140
<400> 7804

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
  1               5                  10                  15
Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
             20                  25                  30
Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
         35                  40                  45
Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
     50                  55                  60
His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
 65                  70                  75                  80
Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                 85                  90                  95
Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
             100                105                110
Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
         115                120                125
Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
     130                135                140
Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
 145                150                155                160
Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                 165                170                175
Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
             180                185                190
Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
         195                200                205
Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
     210                215                220
Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
 225                230                235                240
Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                 245                250                255
Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
             260                265                270
Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
         275                280                285
Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
     290                295                300
Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
 305                310                315                320
Ala Asn Pro Pro Lys Lys Arg 
                 325



<210> 7805
<211> 3001
<212> DNA
<213> Rattus norvegicus
<308> S78556
<400> 7805

cggcacgag  gttcttgcc  tcgtagccc  ctgtccagc  gccatgata  gcgccagca  60
agccgcggc  gcgcgtctc  tgggcacca  agcgtcccg  agtcccgcc  ccgcccgtc  120
ccaggatgg  tggaatggc  ttagtcatg  ggcttttag  tttgtttca  gaagggatt  180
tgcgtcaga  gcaatcaag  gtgcagttg  tggaattga  ttgggtact  ctaactcct  240
tgtggctgt  atggagggc  aacaagcca  ggtcctgga  aacgccgaa  gtgccagaa  300
taccccttc  gtggttgcc  ttacaccag  tggggagcg  cttgttggt  tgccagcaa  360
acgacaagc  gtcaccaat  caaacaata  cttctatgc  acaaagcgt  ttattggac  420
acgatatga  gaccctgaa  tacagaaag  cactaagaa  gttcccttt  aaattgtcc  480
tgcctccaa  ggtgatgcc  gggtggagg  tcatggaaa  ctctattct  cgagtcaga  540
tggagcgtt  gtgttgatg  agatgaaag  gactgcaga  aattacttg  gccatacag  600
aaaaaatgc  gtgatcaca  tccctgctt  tttcaatga  tcacagcga  aggccacta  660
ggatgctgg  cagatatct  ggctaaatg  gctccgagt  atcaacgag  ctacagctg  720
agctctggc  tacggtctg  acaaatccg  agacaaagt  attgctgta  atgatttag  780
tggaggaac  tttgacatt  ctatcctgg  aattcagaa  ggagtgttt  aggtgaaat  840
caccaatgg  gacactttc  taggaggtg  agactttga  caagctttg  tacggcaca  900
tgtcaagga  ttcaagagg  agacagggg  tgatttgac  aaagacaac  tggcgcttc  960
gagggttcg  gaagctgct  agaaggcta  atgtgagct  tcctcatct  tacagactg  1020
catcaactt  ccatacctt  caatggatg  ttctggacc  aagcatttg  atatgaagt  1080
gactcgagc  cagtttgaa  gcattgtca  agatctaat  aagagaact  ttgctccgt  1140
tcagaaagc  atgcaggat  cagaagtca  caagagtga  ataggagaa  tgatcctgg  1200
tggtggcat  acgaggatg  ccaaggttc  gcagactgt  caagatctt  ttggcagag  1260
cccaagtaa  gctgttaat  ctgatgagg  tgtagccat  ggagctgcc  ttcaaggag  1320
tgtgttggc  ggtgatgtt  cagatgtgc  actcttgga  gtcactccc  tctctctag  1380
tattgagac  cttggaggt  tctttacca  gcttattaa  aggaacacc  ctattccaa  1440
caaaaagag  caggtattt  ctactgctg  tgatggaca  actcaagta  agattaaag  1500
gtgtcaggg  gaaagagag  tggccggag  caacaaact  ctaggacag  tcactttga  1560
tggaattcc  ccagcccct  gtggagtgc  tcagattga  gttacattt  acattgatg  1620
caatgggat  gtgcacgtt  ctgccaaag  taaagggac  ggacgtgag  aacagattg  1680
aatccagtc  tctggtgga  taagcaaag  tgatattga  aacatggtt  aaaatgcag  1740
gaagtacgc  gaagaagac  ggaggaaga  ggaacgtgt  gaagcagtt  atatggctg  1800
aggaattat  catgacaca  aaaccaaga  ggaagaatt  aaggaccag  tgcctgctg  1860
cgagtgcaa  aagctaaag  aagagattt  caaaatgag  gaactcctt  ctcgaaagg  1920
cagtgaaac  ggagaaaac  ttaggcagg  ggcatcttc  cttcagcag  catcattga  1980
actctttga  atggcatat  aaaagatgg  atctgaacg  gaaggttct  gaagttcta  2040
cactgggga  cagaaggaa  atcagaagg  agagaaaca  taatagtgg  agtgcattg  2100
ggagctagg  cgacatact  tgaagcttg  gagtaaagg  acttcctga  cagaaaagg  2160
gcaaacttc  gtcttttta  tgtattttt  cagtattct  tatataatt  ccttaatat  2220
taaatccag  gacaatata  aaatccagt  acaatagct  taactcatt  aatggtaat  2280
aagtcagca  tagcaggtt  acacttcta  aactagcct  ctgttttca  ctgcacgta  2340
aggggtggg  tggggctgt  taccaatca  tattaggta  atctggttt  tgctgaagt  2400
gctatgttt  cgagatgga  gcccatttc  catgcagta  aggtaatct  tcatggacc  2460
tgaattgag  ttcatatgc  gatgcttgt  gaccaagag  actgctata  atgacctgt  2520
tgtacattt  ctccttcaa  tgatgcctt  caagactaa  ctctctgtg  catggtcta  2580
aggtacaga  gttaggtca  tggataaca  ctgtgttag  catagctta  agtgatcta  2640
caagaatta  acaagcctc  catgggcct  aggcatact  ctccagcta  cctcttggg  2700
ggccaatgt  tgacatcta  attcttgat  attgttcct  tttcatcca  tctggattt  2760
ttttttttt  aataaaatt  tgaaagcct  ttgatctcc  ttgtgaatg  tagtagctc  2820
aggactatg  ctgtaccat  aggtttgtg  gtagaggta  aaaatcaac  ctggctaaa  2880
ggttgaaca  attaaacat  gtgagggac  aaataacat  ttggcatgt  tgctggatg  2940
ggaagccca  tcaggaagc  gtgtgaagc  aggcggggc  acacaatga  acaccccgt  3000
t  3001



<210> 7806
<211> 679
<212> PRT
<213> Rattus norvegicus
<308> AAB34982
<400> 7806

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Thr Thr 
  1               5                  10                  15
Ala Ser Arg Ser Pro Ala Ala Ala Arg His Gln Asp Gly Trp Asn Gly 
             20                  25                  30
Leu Ser His Glu Val Phe Arg Phe Val Ser Arg Arg Asp Tyr Ala Ser 
         35                  40                  45
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
     50                  55                  60
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
 65                  70                  75                  80
Ser Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Pro Asp 
                 85                  90                  95
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
             100                105                110
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
         115                120                125
Asp Asp Pro Glu Val Gln Lys Asp Thr Lys Asn Val Pro Phe Lys Ile 
     130                135                140
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
 145                150                155                160
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                 165                170                175
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
             180                185                190
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
         195                200                205
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
     210                215                220
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
 225                230                235                240
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                 245                250                255
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
             260                265                270
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
         275                280                285
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
     290                295                300
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
 305                310                315                320
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ala 
                 325                330                335
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
             340                345                350
Gly Ile Val Thr Asp Leu Ile Lys Arg Thr Ile Ala Pro Cys Gln Lys 
         355                360                365
Ala Met Gln Asp Arg Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
     370                375                380
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
 385                390                395                400
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                 405                410                415
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
             420                425                430
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
         435                440                445
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
     450                455                460
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
 465                470                475                480
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                 485                490                495
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
             500                505                510
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
         515                520                525
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
     530                535                540
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
 545                550                555                560
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                 565                570                575
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Val His Asp Thr 
             580                585                590
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
         595                600                605
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
     610                615                620
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
 625                630                635                640
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                 645                650                655
Ser Glu Arg Glu Gly Ser Gly Ser Ser Ser Thr Gly Glu Gln Lys Glu 
             660                665                670
Asp Gln Lys Glu Glu Lys Gln 
         675



<210> 7807
<211> 2811
<212> DNA
<213> Homo sapiens
<308> NM_004134
<400> 7807

ggcacgagg  gagcgcttg  ttgctgcct  gtactcctc  atttatccg  catgataag  60
gccagccga  ctgcagcag  ccgtctcgt  ggcgccgca  cctcccggg  ccctacggc  120
gcccgccac  aggatagct  gaatggcct  agtcatgag  cttttagac  tgtttcaag  180
cgggattat  catcagaag  aatcaaggg  gcagttgtt  gtattgatt  gggtactac  240
aactcctgc  tggcagtta  ggaaggtaa  cgagcaaag  tgctggaga  tgccgaagg  300
gccagaacc  ccccttcag  tgtggcctt  acagcagat  gtgagcgac  tgttggaat  360
ccggccaag  gacaggctg  caccaaccc  aacaataca  tttatgcta  caagcgtct  420
attggccgg  gatatgatg  tcctgaagt  cagaaagac  ttaaaaatg  tccctttaa  480
attgtccgt  cctccaatg  tgatgcctg  gttgaggct  atgggaaat  gtattctcc  540
agtcagatt  gagcatttg  gttgatgaa  atgaaagag  ctgcagaaa  ttacttggg  600
cgcacagca  aaaatgctg  gatcacagt  ccagcttat  tcaatgact  gcagagaca  660
gccactaaa  atgctggcc  gatatctgg  ctgaatgtg  ttcgggtga  taatgagcc  720
acagctgct  ctcttgcct  tggtctaga  aaatcagaa  acaaagtca  tgctgtata  780
gatttaggt  gtggaactt  tgatatttc  atcctggaa  ttcagaaag  agtatttga  840
gtgaaatcc  caaatgggg  taccttctt  ggtggggaa  actttgacc  ggccttgct  900
cggcacatt  tgaaggagt  caagagaga  acaggggtt  atttgacta  agacaacat  960
gcacttcag  gggtacggg  agctgctga  aaggctaag  gtgaactct  ctcatctgt  1020
cagactgac  tcaatttgc  ctatcttac  atggattct  ctggaccca  gcatttgaa  1080
atgaagttg  cccgtgctc  atttgaagg  attgtcact  atctaatca  aaggactat  1140
gctccatgc  aaaaagcta  gcaagatgc  gaagtcagc  agagtgaca  aggagaagt  1200
attcttgtg  gtggcatga  taggatgcc  aaggttcag  agactgtac  ggatctttt  1260
ggcagagcc  caagtaaag  tgtcaatcc  gatgaggct  tggccattg  agctgccat  1320
cagggaggt  tgttggccg  cgatgtcac  gatgtgctg  tccttgatg  cactcccct  1380
tctctgggt  ttgaaactc  aggaggtgt  tttaccaaa  ttattaata  gaataccac  1440
attccaacc  agaagagcc  ggtattctc  actgccgct  atggtcaaa  gcaagtgga  1500
attaaagtg  gtcagggtg  aagagagat  gctggagac  acaaactcc  tggacagtt  1560
actttgatt  gaattccac  agcccctcg  ggagttcct  agattgaag  tacatttga  1620
attgatgcc  atgggatag  acatgtttc  gctaaagat  aaggcacag  acgtgagca  1680
cagattgta  tccagtctt  tggtggatt  agcaaagat  atattgaaa  tatggttaa  1740
aatgcagag  aatatgctg  agaagaccg  cgaaagaag  aacgagttg  agcagttaa  1800
atggctgaa  gaatcattc  cgacacaga  accaagatg  aagaattca  ggaccaatt  1860
cctgctgat  agtgcaaca  gctgaaaga  gagatttcc  aaatgaggg  gctcctggc  1920
agaaaagac  gcgaaacag  agaaaatat  agacaggca  catcctctc  tcagcaggc  1980
tcattgaag  tgttcgaaa  ggcatacaa  aagatggca  ctgagcgag  aggctctgg  2040
agttctggc  ctggggaac  aaaggaaga  caaaaggag  aaaaacagt  ataatagca  2100
aaattttga  gccagaagg  caacatatg  agcttagga  tgaagagac  tcctgagca  2160
aaatgggcg  acttcagtc  ttttactgt  tttttgcag  attctatat  taatttcct  2220
aatttgtaa  tttagtgac  attagctag  gatcattta  tggacagtg  ttctaacag  2280
ataaagttc  caatattct  tgtccctag  ctgtcattt  tcagctgca  gtaaaagga  2340
gtaggatga  ttgatcatt  taaagattt  actatttta  gctgaagtg  ccatatttt  2400
aaggggtga  accatctcg  acacagcaa  gaaggtagt  atccataga  ttgaaatga  2460
accacatat  gggatgaga  ccttctagt  agcctagta  tgctgtact  gcctgtatg  2520
acatggggt  cttcaactg  ggccttgca  gtcaagctg  ctgtgccat  tttgtagat  2580
gggcagagg  atctagaac  atgggaaac  tagctattt  tattaggta  agctattaa  2640
acaaggtag  aatgaggct  gacctttaa  ttccctaag  catactttt  tagctacct  2700
ctgccctgt  tctggcacc  acatccttg  tgattgttc  cttacccat  ctggaattt  2760
ttttttttt  aaataaata  agaaagcat  ttgaaaaaa  aaaaaaaaa  a  2811



<210> 7808
<211> 679
<212> PRT
<213> Homo sapiens
<308> P38646
<400> 7808

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
  1               5                  10                  15
Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
             20                  25                  30
Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
         35                  40                  45
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
     50                  55                  60
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
 65                  70                  75                  80
Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                 85                  90                  95
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
             100                105                110
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
         115                120                125
Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
     130                135                140
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
 145                150                155                160
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                 165                170                175
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
             180                185                190
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
         195                200                205
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
     210                215                220
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
 225                230                235                240
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                 245                250                255
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
             260                265                270
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
         275                280                285
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
     290                295                300
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
 305                310                315                320
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                 325                330                335
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
             340                345                350
Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
         355                360                365
Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
     370                375                380
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
 385                390                395                400
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                 405                410                415
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
             420                425                430
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
         435                440                445
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
     450                455                460
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
 465                470                475                480
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                 485                490                495
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
             500                505                510
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
         515                520                525
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
     530                535                540
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
 545                550                555                560
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                 565                570                575
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
             580                585                590
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
         595                600                605
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
     610                615                620
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
 625                630                635                640
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                 645                650                655
Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
             660                665                670
Asp Gln Lys Glu Glu Lys Gln 
         675



<210> 7809
<211> 3001
<212> DNA
<213> Rattus norvegicus
<308> S78556
<400> 7809

cggcacgag  gttcttgcc  tcgtagccc  ctgtccagc  gccatgata  gcgccagca  60
agccgcggc  gcgcgtctc  tgggcacca  agcgtcccg  agtcccgcc  ccgcccgtc  120
ccaggatgg  tggaatggc  ttagtcatg  ggcttttag  tttgtttca  gaagggatt  180
tgcgtcaga  gcaatcaag  gtgcagttg  tggaattga  ttgggtact  ctaactcct  240
tgtggctgt  atggagggc  aacaagcca  ggtcctgga  aacgccgaa  gtgccagaa  300
taccccttc  gtggttgcc  ttacaccag  tggggagcg  cttgttggt  tgccagcaa  360
acgacaagc  gtcaccaat  caaacaata  cttctatgc  acaaagcgt  ttattggac  420
acgatatga  gaccctgaa  tacagaaag  cactaagaa  gttcccttt  aaattgtcc  480
tgcctccaa  ggtgatgcc  gggtggagg  tcatggaaa  ctctattct  cgagtcaga  540
tggagcgtt  gtgttgatg  agatgaaag  gactgcaga  aattacttg  gccatacag  600
aaaaaatgc  gtgatcaca  tccctgctt  tttcaatga  tcacagcga  aggccacta  660
ggatgctgg  cagatatct  ggctaaatg  gctccgagt  atcaacgag  ctacagctg  720
agctctggc  tacggtctg  acaaatccg  agacaaagt  attgctgta  atgatttag  780
tggaggaac  tttgacatt  ctatcctgg  aattcagaa  ggagtgttt  aggtgaaat  840
caccaatgg  gacactttc  taggaggtg  agactttga  caagctttg  tacggcaca  900
tgtcaagga  ttcaagagg  agacagggg  tgatttgac  aaagacaac  tggcgcttc  960
gagggttcg  gaagctgct  agaaggcta  atgtgagct  tcctcatct  tacagactg  1020
catcaactt  ccatacctt  caatggatg  ttctggacc  aagcatttg  atatgaagt  1080
gactcgagc  cagtttgaa  gcattgtca  agatctaat  aagagaact  ttgctccgt  1140
tcagaaagc  atgcaggat  cagaagtca  caagagtga  ataggagaa  tgatcctgg  1200
tggtggcat  acgaggatg  ccaaggttc  gcagactgt  caagatctt  ttggcagag  1260
cccaagtaa  gctgttaat  ctgatgagg  tgtagccat  ggagctgcc  ttcaaggag  1320
tgtgttggc  ggtgatgtt  cagatgtgc  actcttgga  gtcactccc  tctctctag  1380
tattgagac  cttggaggt  tctttacca  gcttattaa  aggaacacc  ctattccaa  1440
caaaaagag  caggtattt  ctactgctg  tgatggaca  actcaagta  agattaaag  1500
gtgtcaggg  gaaagagag  tggccggag  caacaaact  ctaggacag  tcactttga  1560
tggaattcc  ccagcccct  gtggagtgc  tcagattga  gttacattt  acattgatg  1620
caatgggat  gtgcacgtt  ctgccaaag  taaagggac  ggacgtgag  aacagattg  1680
aatccagtc  tctggtgga  taagcaaag  tgatattga  aacatggtt  aaaatgcag  1740
gaagtacgc  gaagaagac  ggaggaaga  ggaacgtgt  gaagcagtt  atatggctg  1800
aggaattat  catgacaca  aaaccaaga  ggaagaatt  aaggaccag  tgcctgctg  1860
cgagtgcaa  aagctaaag  aagagattt  caaaatgag  gaactcctt  ctcgaaagg  1920
cagtgaaac  ggagaaaac  ttaggcagg  ggcatcttc  cttcagcag  catcattga  1980
actctttga  atggcatat  aaaagatgg  atctgaacg  gaaggttct  gaagttcta  2040
cactgggga  cagaaggaa  atcagaagg  agagaaaca  taatagtgg  agtgcattg  2100
ggagctagg  cgacatact  tgaagcttg  gagtaaagg  acttcctga  cagaaaagg  2160
gcaaacttc  gtcttttta  tgtattttt  cagtattct  tatataatt  ccttaatat  2220
taaatccag  gacaatata  aaatccagt  acaatagct  taactcatt  aatggtaat  2280
aagtcagca  tagcaggtt  acacttcta  aactagcct  ctgttttca  ctgcacgta  2340
aggggtggg  tggggctgt  taccaatca  tattaggta  atctggttt  tgctgaagt  2400
gctatgttt  cgagatgga  gcccatttc  catgcagta  aggtaatct  tcatggacc  2460
tgaattgag  ttcatatgc  gatgcttgt  gaccaagag  actgctata  atgacctgt  2520
tgtacattt  ctccttcaa  tgatgcctt  caagactaa  ctctctgtg  catggtcta  2580
aggtacaga  gttaggtca  tggataaca  ctgtgttag  catagctta  agtgatcta  2640
caagaatta  acaagcctc  catgggcct  aggcatact  ctccagcta  cctcttggg  2700
ggccaatgt  tgacatcta  attcttgat  attgttcct  tttcatcca  tctggattt  2760
ttttttttt  aataaaatt  tgaaagcct  ttgatctcc  ttgtgaatg  tagtagctc  2820
aggactatg  ctgtaccat  aggtttgtg  gtagaggta  aaaatcaac  ctggctaaa  2880
ggttgaaca  attaaacat  gtgagggac  aaataacat  ttggcatgt  tgctggatg  2940
ggaagccca  tcaggaagc  gtgtgaagc  aggcggggc  acacaatga  acaccccgt  3000
t  3001



<210> 7810
<211> 679
<212> PRT
<213> Rattus norvegicus
<308> AAB34982
<400> 7810

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Thr Thr 
  1               5                  10                  15
Ala Ser Arg Ser Pro Ala Ala Ala Arg His Gln Asp Gly Trp Asn Gly 
             20                  25                  30
Leu Ser His Glu Val Phe Arg Phe Val Ser Arg Arg Asp Tyr Ala Ser 
         35                  40                  45
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
     50                  55                  60
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
 65                  70                  75                  80
Ser Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Pro Asp 
                 85                  90                  95
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
             100                105                110
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
         115                120                125
Asp Asp Pro Glu Val Gln Lys Asp Thr Lys Asn Val Pro Phe Lys Ile 
     130                135                140
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
 145                150                155                160
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                 165                170                175
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
             180                185                190
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
         195                200                205
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
     210                215                220
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
 225                230                235                240
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                 245                250                255
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
             260                265                270
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
         275                280                285
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
     290                295                300
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
 305                310                315                320
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ala 
                 325                330                335
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
             340                345                350
Gly Ile Val Thr Asp Leu Ile Lys Arg Thr Ile Ala Pro Cys Gln Lys 
         355                360                365
Ala Met Gln Asp Arg Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
     370                375                380
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
 385                390                395                400
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                 405                410                415
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
             420                425                430
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
         435                440                445
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
     450                455                460
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
 465                470                475                480
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                 485                490                495
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
             500                505                510
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
         515                520                525
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
     530                535                540
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
 545                550                555                560
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                 565                570                575
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Val His Asp Thr 
             580                585                590
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
         595                600                605
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
     610                615                620
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
 625                630                635                640
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                 645                650                655
Ser Glu Arg Glu Gly Ser Gly Ser Ser Ser Thr Gly Glu Gln Lys Glu 
             660                665                670
Asp Gln Lys Glu Glu Lys Gln 
         675



<210> 7811
<211> 2811
<212> DNA
<213> Homo sapiens
<308> NM_004134
<400> 7811

ggcacgagg  gagcgcttg  ttgctgcct  gtactcctc  atttatccg  catgataag  60
gccagccga  ctgcagcag  ccgtctcgt  ggcgccgca  cctcccggg  ccctacggc  120
gcccgccac  aggatagct  gaatggcct  agtcatgag  cttttagac  tgtttcaag  180
cgggattat  catcagaag  aatcaaggg  gcagttgtt  gtattgatt  gggtactac  240
aactcctgc  tggcagtta  ggaaggtaa  cgagcaaag  tgctggaga  tgccgaagg  300
gccagaacc  ccccttcag  tgtggcctt  acagcagat  gtgagcgac  tgttggaat  360
ccggccaag  gacaggctg  caccaaccc  aacaataca  tttatgcta  caagcgtct  420
attggccgg  gatatgatg  tcctgaagt  cagaaagac  ttaaaaatg  tccctttaa  480
attgtccgt  cctccaatg  tgatgcctg  gttgaggct  atgggaaat  gtattctcc  540
agtcagatt  gagcatttg  gttgatgaa  atgaaagag  ctgcagaaa  ttacttggg  600
cgcacagca  aaaatgctg  gatcacagt  ccagcttat  tcaatgact  gcagagaca  660
gccactaaa  atgctggcc  gatatctgg  ctgaatgtg  ttcgggtga  taatgagcc  720
acagctgct  ctcttgcct  tggtctaga  aaatcagaa  acaaagtca  tgctgtata  780
gatttaggt  gtggaactt  tgatatttc  atcctggaa  ttcagaaag  agtatttga  840
gtgaaatcc  caaatgggg  taccttctt  ggtggggaa  actttgacc  ggccttgct  900
cggcacatt  tgaaggagt  caagagaga  acaggggtt  atttgacta  agacaacat  960
gcacttcag  gggtacggg  agctgctga  aaggctaag  gtgaactct  ctcatctgt  1020
cagactgac  tcaatttgc  ctatcttac  atggattct  ctggaccca  gcatttgaa  1080
atgaagttg  cccgtgctc  atttgaagg  attgtcact  atctaatca  aaggactat  1140
gctccatgc  aaaaagcta  gcaagatgc  gaagtcagc  agagtgaca  aggagaagt  1200
attcttgtg  gtggcatga  taggatgcc  aaggttcag  agactgtac  ggatctttt  1260
ggcagagcc  caagtaaag  tgtcaatcc  gatgaggct  tggccattg  agctgccat  1320
cagggaggt  tgttggccg  cgatgtcac  gatgtgctg  tccttgatg  cactcccct  1380
tctctgggt  ttgaaactc  aggaggtgt  tttaccaaa  ttattaata  gaataccac  1440
attccaacc  agaagagcc  ggtattctc  actgccgct  atggtcaaa  gcaagtgga  1500
attaaagtg  gtcagggtg  aagagagat  gctggagac  acaaactcc  tggacagtt  1560
actttgatt  gaattccac  agcccctcg  ggagttcct  agattgaag  tacatttga  1620
attgatgcc  atgggatag  acatgtttc  gctaaagat  aaggcacag  acgtgagca  1680
cagattgta  tccagtctt  tggtggatt  agcaaagat  atattgaaa  tatggttaa  1740
aatgcagag  aatatgctg  agaagaccg  cgaaagaag  aacgagttg  agcagttaa  1800
atggctgaa  gaatcattc  cgacacaga  accaagatg  aagaattca  ggaccaatt  1860
cctgctgat  agtgcaaca  gctgaaaga  gagatttcc  aaatgaggg  gctcctggc  1920
agaaaagac  gcgaaacag  agaaaatat  agacaggca  catcctctc  tcagcaggc  1980
tcattgaag  tgttcgaaa  ggcatacaa  aagatggca  ctgagcgag  aggctctgg  2040
agttctggc  ctggggaac  aaaggaaga  caaaaggag  aaaaacagt  ataatagca  2100
aaattttga  gccagaagg  caacatatg  agcttagga  tgaagagac  tcctgagca  2160
aaatgggcg  acttcagtc  ttttactgt  tttttgcag  attctatat  taatttcct  2220
aatttgtaa  tttagtgac  attagctag  gatcattta  tggacagtg  ttctaacag  2280
ataaagttc  caatattct  tgtccctag  ctgtcattt  tcagctgca  gtaaaagga  2340
gtaggatga  ttgatcatt  taaagattt  actatttta  gctgaagtg  ccatatttt  2400
aaggggtga  accatctcg  acacagcaa  gaaggtagt  atccataga  ttgaaatga  2460
accacatat  gggatgaga  ccttctagt  agcctagta  tgctgtact  gcctgtatg  2520
acatggggt  cttcaactg  ggccttgca  gtcaagctg  ctgtgccat  tttgtagat  2580
gggcagagg  atctagaac  atgggaaac  tagctattt  tattaggta  agctattaa  2640
acaaggtag  aatgaggct  gacctttaa  ttccctaag  catactttt  tagctacct  2700
ctgccctgt  tctggcacc  acatccttg  tgattgttc  cttacccat  ctggaattt  2760
ttttttttt  aaataaata  agaaagcat  ttgaaaaaa  aaaaaaaaa  a  2811



<210> 7812
<211> 679
<212> PRT
<213> Homo sapiens
<308> P38646
<400> 7812

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
  1               5                  10                  15
Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
             20                  25                  30
Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
         35                  40                  45
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
     50                  55                  60
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
 65                  70                  75                  80
Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                 85                  90                  95
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
             100                105                110
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
         115                120                125
Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
     130                135                140
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
 145                150                155                160
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                 165                170                175
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
             180                185                190
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
         195                200                205
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
     210                215                220
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
 225                230                235                240
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                 245                250                255
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
             260                265                270
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
         275                280                285
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
     290                295                300
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
 305                310                315                320
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                 325                330                335
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
             340                345                350
Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
         355                360                365
Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
     370                375                380
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
 385                390                395                400
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                 405                410                415
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
             420                425                430
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
         435                440                445
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
     450                455                460
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
 465                470                475                480
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                 485                490                495
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
             500                505                510
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
         515                520                525
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
     530                535                540
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
 545                550                555                560
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                 565                570                575
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
             580                585                590
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
         595                600                605
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
     610                615                620
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
 625                630                635                640
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                 645                650                655
Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
             660                665                670
Asp Gln Lys Glu Glu Lys Gln 
         675



<210> 7813
<211> 3001
<212> DNA
<213> Rattus norvegicus
<308> S78556
<400> 7813

cggcacgag  gttcttgcc  tcgtagccc  ctgtccagc  gccatgata  gcgccagca  60
agccgcggc  gcgcgtctc  tgggcacca  agcgtcccg  agtcccgcc  ccgcccgtc  120
ccaggatgg  tggaatggc  ttagtcatg  ggcttttag  tttgtttca  gaagggatt  180
tgcgtcaga  gcaatcaag  gtgcagttg  tggaattga  ttgggtact  ctaactcct  240
tgtggctgt  atggagggc  aacaagcca  ggtcctgga  aacgccgaa  gtgccagaa  300
taccccttc  gtggttgcc  ttacaccag  tggggagcg  cttgttggt  tgccagcaa  360
acgacaagc  gtcaccaat  caaacaata  cttctatgc  acaaagcgt  ttattggac  420
acgatatga  gaccctgaa  tacagaaag  cactaagaa  gttcccttt  aaattgtcc  480
tgcctccaa  ggtgatgcc  gggtggagg  tcatggaaa  ctctattct  cgagtcaga  540
tggagcgtt  gtgttgatg  agatgaaag  gactgcaga  aattacttg  gccatacag  600
aaaaaatgc  gtgatcaca  tccctgctt  tttcaatga  tcacagcga  aggccacta  660
ggatgctgg  cagatatct  ggctaaatg  gctccgagt  atcaacgag  ctacagctg  720
agctctggc  tacggtctg  acaaatccg  agacaaagt  attgctgta  atgatttag  780
tggaggaac  tttgacatt  ctatcctgg  aattcagaa  ggagtgttt  aggtgaaat  840
caccaatgg  gacactttc  taggaggtg  agactttga  caagctttg  tacggcaca  900
tgtcaagga  ttcaagagg  agacagggg  tgatttgac  aaagacaac  tggcgcttc  960
gagggttcg  gaagctgct  agaaggcta  atgtgagct  tcctcatct  tacagactg  1020
catcaactt  ccatacctt  caatggatg  ttctggacc  aagcatttg  atatgaagt  1080
gactcgagc  cagtttgaa  gcattgtca  agatctaat  aagagaact  ttgctccgt  1140
tcagaaagc  atgcaggat  cagaagtca  caagagtga  ataggagaa  tgatcctgg  1200
tggtggcat  acgaggatg  ccaaggttc  gcagactgt  caagatctt  ttggcagag  1260
cccaagtaa  gctgttaat  ctgatgagg  tgtagccat  ggagctgcc  ttcaaggag  1320
tgtgttggc  ggtgatgtt  cagatgtgc  actcttgga  gtcactccc  tctctctag  1380
tattgagac  cttggaggt  tctttacca  gcttattaa  aggaacacc  ctattccaa  1440
caaaaagag  caggtattt  ctactgctg  tgatggaca  actcaagta  agattaaag  1500
gtgtcaggg  gaaagagag  tggccggag  caacaaact  ctaggacag  tcactttga  1560
tggaattcc  ccagcccct  gtggagtgc  tcagattga  gttacattt  acattgatg  1620
caatgggat  gtgcacgtt  ctgccaaag  taaagggac  ggacgtgag  aacagattg  1680
aatccagtc  tctggtgga  taagcaaag  tgatattga  aacatggtt  aaaatgcag  1740
gaagtacgc  gaagaagac  ggaggaaga  ggaacgtgt  gaagcagtt  atatggctg  1800
aggaattat  catgacaca  aaaccaaga  ggaagaatt  aaggaccag  tgcctgctg  1860
cgagtgcaa  aagctaaag  aagagattt  caaaatgag  gaactcctt  ctcgaaagg  1920
cagtgaaac  ggagaaaac  ttaggcagg  ggcatcttc  cttcagcag  catcattga  1980
actctttga  atggcatat  aaaagatgg  atctgaacg  gaaggttct  gaagttcta  2040
cactgggga  cagaaggaa  atcagaagg  agagaaaca  taatagtgg  agtgcattg  2100
ggagctagg  cgacatact  tgaagcttg  gagtaaagg  acttcctga  cagaaaagg  2160
gcaaacttc  gtcttttta  tgtattttt  cagtattct  tatataatt  ccttaatat  2220
taaatccag  gacaatata  aaatccagt  acaatagct  taactcatt  aatggtaat  2280
aagtcagca  tagcaggtt  acacttcta  aactagcct  ctgttttca  ctgcacgta  2340
aggggtggg  tggggctgt  taccaatca  tattaggta  atctggttt  tgctgaagt  2400
gctatgttt  cgagatgga  gcccatttc  catgcagta  aggtaatct  tcatggacc  2460
tgaattgag  ttcatatgc  gatgcttgt  gaccaagag  actgctata  atgacctgt  2520
tgtacattt  ctccttcaa  tgatgcctt  caagactaa  ctctctgtg  catggtcta  2580
aggtacaga  gttaggtca  tggataaca  ctgtgttag  catagctta  agtgatcta  2640
caagaatta  acaagcctc  catgggcct  aggcatact  ctccagcta  cctcttggg  2700
ggccaatgt  tgacatcta  attcttgat  attgttcct  tttcatcca  tctggattt  2760
ttttttttt  aataaaatt  tgaaagcct  ttgatctcc  ttgtgaatg  tagtagctc  2820
aggactatg  ctgtaccat  aggtttgtg  gtagaggta  aaaatcaac  ctggctaaa  2880
ggttgaaca  attaaacat  gtgagggac  aaataacat  ttggcatgt  tgctggatg  2940
ggaagccca  tcaggaagc  gtgtgaagc  aggcggggc  acacaatga  acaccccgt  3000
t  3001



<210> 7814
<211> 679
<212> PRT
<213> Rattus norvegicus
<308> AAB34982
<400> 7814

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Thr Thr 
  1               5                  10                  15
Ala Ser Arg Ser Pro Ala Ala Ala Arg His Gln Asp Gly Trp Asn Gly 
             20                  25                  30
Leu Ser His Glu Val Phe Arg Phe Val Ser Arg Arg Asp Tyr Ala Ser 
         35                  40                  45
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
     50                  55                  60
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
 65                  70                  75                  80
Ser Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Pro Asp 
                 85                  90                  95
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
             100                105                110
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
         115                120                125
Asp Asp Pro Glu Val Gln Lys Asp Thr Lys Asn Val Pro Phe Lys Ile 
     130                135                140
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
 145                150                155                160
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                 165                170                175
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
             180                185                190
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
         195                200                205
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
     210                215                220
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
 225                230                235                240
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                 245                250                255
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
             260                265                270
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
         275                280                285
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
     290                295                300
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
 305                310                315                320
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ala 
                 325                330                335
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
             340                345                350
Gly Ile Val Thr Asp Leu Ile Lys Arg Thr Ile Ala Pro Cys Gln Lys 
         355                360                365
Ala Met Gln Asp Arg Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
     370                375                380
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
 385                390                395                400
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                 405                410                415
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
             420                425                430
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
         435                440                445
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
     450                455                460
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
 465                470                475                480
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                 485                490                495
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
             500                505                510
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
         515                520                525
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
     530                535                540
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
 545                550                555                560
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                 565                570                575
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Val His Asp Thr 
             580                585                590
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
         595                600                605
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
     610                615                620
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
 625                630                635                640
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                 645                650                655
Ser Glu Arg Glu Gly Ser Gly Ser Ser Ser Thr Gly Glu Gln Lys Glu 
             660                665                670
Asp Gln Lys Glu Glu Lys Gln 
         675



<210> 7815
<211> 2811
<212> DNA
<213> Homo sapiens
<308> NM_004134
<400> 7815

ggcacgagg  gagcgcttg  ttgctgcct  gtactcctc  atttatccg  catgataag  60
gccagccga  ctgcagcag  ccgtctcgt  ggcgccgca  cctcccggg  ccctacggc  120
gcccgccac  aggatagct  gaatggcct  agtcatgag  cttttagac  tgtttcaag  180
cgggattat  catcagaag  aatcaaggg  gcagttgtt  gtattgatt  gggtactac  240
aactcctgc  tggcagtta  ggaaggtaa  cgagcaaag  tgctggaga  tgccgaagg  300
gccagaacc  ccccttcag  tgtggcctt  acagcagat  gtgagcgac  tgttggaat  360
ccggccaag  gacaggctg  caccaaccc  aacaataca  tttatgcta  caagcgtct  420
attggccgg  gatatgatg  tcctgaagt  cagaaagac  ttaaaaatg  tccctttaa  480
attgtccgt  cctccaatg  tgatgcctg  gttgaggct  atgggaaat  gtattctcc  540
agtcagatt  gagcatttg  gttgatgaa  atgaaagag  ctgcagaaa  ttacttggg  600
cgcacagca  aaaatgctg  gatcacagt  ccagcttat  tcaatgact  gcagagaca  660
gccactaaa  atgctggcc  gatatctgg  ctgaatgtg  ttcgggtga  taatgagcc  720
acagctgct  ctcttgcct  tggtctaga  aaatcagaa  acaaagtca  tgctgtata  780
gatttaggt  gtggaactt  tgatatttc  atcctggaa  ttcagaaag  agtatttga  840
gtgaaatcc  caaatgggg  taccttctt  ggtggggaa  actttgacc  ggccttgct  900
cggcacatt  tgaaggagt  caagagaga  acaggggtt  atttgacta  agacaacat  960
gcacttcag  gggtacggg  agctgctga  aaggctaag  gtgaactct  ctcatctgt  1020
cagactgac  tcaatttgc  ctatcttac  atggattct  ctggaccca  gcatttgaa  1080
atgaagttg  cccgtgctc  atttgaagg  attgtcact  atctaatca  aaggactat  1140
gctccatgc  aaaaagcta  gcaagatgc  gaagtcagc  agagtgaca  aggagaagt  1200
attcttgtg  gtggcatga  taggatgcc  aaggttcag  agactgtac  ggatctttt  1260
ggcagagcc  caagtaaag  tgtcaatcc  gatgaggct  tggccattg  agctgccat  1320
cagggaggt  tgttggccg  cgatgtcac  gatgtgctg  tccttgatg  cactcccct  1380
tctctgggt  ttgaaactc  aggaggtgt  tttaccaaa  ttattaata  gaataccac  1440
attccaacc  agaagagcc  ggtattctc  actgccgct  atggtcaaa  gcaagtgga  1500
attaaagtg  gtcagggtg  aagagagat  gctggagac  acaaactcc  tggacagtt  1560
actttgatt  gaattccac  agcccctcg  ggagttcct  agattgaag  tacatttga  1620
attgatgcc  atgggatag  acatgtttc  gctaaagat  aaggcacag  acgtgagca  1680
cagattgta  tccagtctt  tggtggatt  agcaaagat  atattgaaa  tatggttaa  1740
aatgcagag  aatatgctg  agaagaccg  cgaaagaag  aacgagttg  agcagttaa  1800
atggctgaa  gaatcattc  cgacacaga  accaagatg  aagaattca  ggaccaatt  1860
cctgctgat  agtgcaaca  gctgaaaga  gagatttcc  aaatgaggg  gctcctggc  1920
agaaaagac  gcgaaacag  agaaaatat  agacaggca  catcctctc  tcagcaggc  1980
tcattgaag  tgttcgaaa  ggcatacaa  aagatggca  ctgagcgag  aggctctgg  2040
agttctggc  ctggggaac  aaaggaaga  caaaaggag  aaaaacagt  ataatagca  2100
aaattttga  gccagaagg  caacatatg  agcttagga  tgaagagac  tcctgagca  2160
aaatgggcg  acttcagtc  ttttactgt  tttttgcag  attctatat  taatttcct  2220
aatttgtaa  tttagtgac  attagctag  gatcattta  tggacagtg  ttctaacag  2280
ataaagttc  caatattct  tgtccctag  ctgtcattt  tcagctgca  gtaaaagga  2340
gtaggatga  ttgatcatt  taaagattt  actatttta  gctgaagtg  ccatatttt  2400
aaggggtga  accatctcg  acacagcaa  gaaggtagt  atccataga  ttgaaatga  2460
accacatat  gggatgaga  ccttctagt  agcctagta  tgctgtact  gcctgtatg  2520
acatggggt  cttcaactg  ggccttgca  gtcaagctg  ctgtgccat  tttgtagat  2580
gggcagagg  atctagaac  atgggaaac  tagctattt  tattaggta  agctattaa  2640
acaaggtag  aatgaggct  gacctttaa  ttccctaag  catactttt  tagctacct  2700
ctgccctgt  tctggcacc  acatccttg  tgattgttc  cttacccat  ctggaattt  2760
ttttttttt  aaataaata  agaaagcat  ttgaaaaaa  aaaaaaaaa  a  2811



<210> 7816
<211> 679
<212> PRT
<213> Homo sapiens
<308> P38646
<400> 7816

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
  1               5                  10                  15
Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
             20                  25                  30
Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
         35                  40                  45
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
     50                  55                  60
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
 65                  70                  75                  80
Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                 85                  90                  95
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
             100                105                110
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
         115                120                125
Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
     130                135                140
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
 145                150                155                160
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                 165                170                175
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
             180                185                190
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
         195                200                205
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
     210                215                220
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
 225                230                235                240
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                 245                250                255
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
             260                265                270
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
         275                280                285
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
     290                295                300
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
 305                310                315                320
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                 325                330                335
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
             340                345                350
Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
         355                360                365
Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
     370                375                380
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
 385                390                395                400
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                 405                410                415
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
             420                425                430
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
         435                440                445
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
     450                455                460
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
 465                470                475                480
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                 485                490                495
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
             500                505                510
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
         515                520                525
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
     530                535                540
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
 545                550                555                560
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                 565                570                575
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
             580                585                590
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
         595                600                605
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
     610                615                620
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
 625                630                635                640
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                 645                650                655
Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
             660                665                670
Asp Gln Lys Glu Glu Lys Gln 
         675



<210> 7817
<211> 3001
<212> DNA
<213> Rattus norvegicus
<308> S78556
<400> 7817

cggcacgag  gttcttgcc  tcgtagccc  ctgtccagc  gccatgata  gcgccagca  60
agccgcggc  gcgcgtctc  tgggcacca  agcgtcccg  agtcccgcc  ccgcccgtc  120
ccaggatgg  tggaatggc  ttagtcatg  ggcttttag  tttgtttca  gaagggatt  180
tgcgtcaga  gcaatcaag  gtgcagttg  tggaattga  ttgggtact  ctaactcct  240
tgtggctgt  atggagggc  aacaagcca  ggtcctgga  aacgccgaa  gtgccagaa  300
taccccttc  gtggttgcc  ttacaccag  tggggagcg  cttgttggt  tgccagcaa  360
acgacaagc  gtcaccaat  caaacaata  cttctatgc  acaaagcgt  ttattggac  420
acgatatga  gaccctgaa  tacagaaag  cactaagaa  gttcccttt  aaattgtcc  480
tgcctccaa  ggtgatgcc  gggtggagg  tcatggaaa  ctctattct  cgagtcaga  540
tggagcgtt  gtgttgatg  agatgaaag  gactgcaga  aattacttg  gccatacag  600
aaaaaatgc  gtgatcaca  tccctgctt  tttcaatga  tcacagcga  aggccacta  660
ggatgctgg  cagatatct  ggctaaatg  gctccgagt  atcaacgag  ctacagctg  720
agctctggc  tacggtctg  acaaatccg  agacaaagt  attgctgta  atgatttag  780
tggaggaac  tttgacatt  ctatcctgg  aattcagaa  ggagtgttt  aggtgaaat  840
caccaatgg  gacactttc  taggaggtg  agactttga  caagctttg  tacggcaca  900
tgtcaagga  ttcaagagg  agacagggg  tgatttgac  aaagacaac  tggcgcttc  960
gagggttcg  gaagctgct  agaaggcta  atgtgagct  tcctcatct  tacagactg  1020
catcaactt  ccatacctt  caatggatg  ttctggacc  aagcatttg  atatgaagt  1080
gactcgagc  cagtttgaa  gcattgtca  agatctaat  aagagaact  ttgctccgt  1140
tcagaaagc  atgcaggat  cagaagtca  caagagtga  ataggagaa  tgatcctgg  1200
tggtggcat  acgaggatg  ccaaggttc  gcagactgt  caagatctt  ttggcagag  1260
cccaagtaa  gctgttaat  ctgatgagg  tgtagccat  ggagctgcc  ttcaaggag  1320
tgtgttggc  ggtgatgtt  cagatgtgc  actcttgga  gtcactccc  tctctctag  1380
tattgagac  cttggaggt  tctttacca  gcttattaa  aggaacacc  ctattccaa  1440
caaaaagag  caggtattt  ctactgctg  tgatggaca  actcaagta  agattaaag  1500
gtgtcaggg  gaaagagag  tggccggag  caacaaact  ctaggacag  tcactttga  1560
tggaattcc  ccagcccct  gtggagtgc  tcagattga  gttacattt  acattgatg  1620
caatgggat  gtgcacgtt  ctgccaaag  taaagggac  ggacgtgag  aacagattg  1680
aatccagtc  tctggtgga  taagcaaag  tgatattga  aacatggtt  aaaatgcag  1740
gaagtacgc  gaagaagac  ggaggaaga  ggaacgtgt  gaagcagtt  atatggctg  1800
aggaattat  catgacaca  aaaccaaga  ggaagaatt  aaggaccag  tgcctgctg  1860
cgagtgcaa  aagctaaag  aagagattt  caaaatgag  gaactcctt  ctcgaaagg  1920
cagtgaaac  ggagaaaac  ttaggcagg  ggcatcttc  cttcagcag  catcattga  1980
actctttga  atggcatat  aaaagatgg  atctgaacg  gaaggttct  gaagttcta  2040
cactgggga  cagaaggaa  atcagaagg  agagaaaca  taatagtgg  agtgcattg  2100
ggagctagg  cgacatact  tgaagcttg  gagtaaagg  acttcctga  cagaaaagg  2160
gcaaacttc  gtcttttta  tgtattttt  cagtattct  tatataatt  ccttaatat  2220
taaatccag  gacaatata  aaatccagt  acaatagct  taactcatt  aatggtaat  2280
aagtcagca  tagcaggtt  acacttcta  aactagcct  ctgttttca  ctgcacgta  2340
aggggtggg  tggggctgt  taccaatca  tattaggta  atctggttt  tgctgaagt  2400
gctatgttt  cgagatgga  gcccatttc  catgcagta  aggtaatct  tcatggacc  2460
tgaattgag  ttcatatgc  gatgcttgt  gaccaagag  actgctata  atgacctgt  2520
tgtacattt  ctccttcaa  tgatgcctt  caagactaa  ctctctgtg  catggtcta  2580
aggtacaga  gttaggtca  tggataaca  ctgtgttag  catagctta  agtgatcta  2640
caagaatta  acaagcctc  catgggcct  aggcatact  ctccagcta  cctcttggg  2700
ggccaatgt  tgacatcta  attcttgat  attgttcct  tttcatcca  tctggattt  2760
ttttttttt  aataaaatt  tgaaagcct  ttgatctcc  ttgtgaatg  tagtagctc  2820
aggactatg  ctgtaccat  aggtttgtg  gtagaggta  aaaatcaac  ctggctaaa  2880
ggttgaaca  attaaacat  gtgagggac  aaataacat  ttggcatgt  tgctggatg  2940
ggaagccca  tcaggaagc  gtgtgaagc  aggcggggc  acacaatga  acaccccgt  3000
t  3001



<210> 7818
<211> 679
<212> PRT
<213> Rattus norvegicus
<308> AAB34982
<400> 7818

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Thr Thr 
  1               5                  10                  15
Ala Ser Arg Ser Pro Ala Ala Ala Arg His Gln Asp Gly Trp Asn Gly 
             20                  25                  30
Leu Ser His Glu Val Phe Arg Phe Val Ser Arg Arg Asp Tyr Ala Ser 
         35                  40                  45
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
     50                  55                  60
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
 65                  70                  75                  80
Ser Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Pro Asp 
                 85                  90                  95
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
             100                105                110
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
         115                120                125
Asp Asp Pro Glu Val Gln Lys Asp Thr Lys Asn Val Pro Phe Lys Ile 
     130                135                140
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
 145                150                155                160
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                 165                170                175
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
             180                185                190
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
         195                200                205
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
     210                215                220
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
 225                230                235                240
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                 245                250                255
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
             260                265                270
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
         275                280                285
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
     290                295                300
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
 305                310                315                320
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ala 
                 325                330                335
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
             340                345                350
Gly Ile Val Thr Asp Leu Ile Lys Arg Thr Ile Ala Pro Cys Gln Lys 
         355                360                365
Ala Met Gln Asp Arg Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
     370                375                380
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
 385                390                395                400
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                 405                410                415
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
             420                425                430
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
         435                440                445
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
     450                455                460
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
 465                470                475                480
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                 485                490                495
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
             500                505                510
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
         515                520                525
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
     530                535                540
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
 545                550                555                560
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                 565                570                575
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Val His Asp Thr 
             580                585                590
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
         595                600                605
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
     610                615                620
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
 625                630                635                640
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                 645                650                655
Ser Glu Arg Glu Gly Ser Gly Ser Ser Ser Thr Gly Glu Gln Lys Glu 
             660                665                670
Asp Gln Lys Glu Glu Lys Gln 
         675



<210> 7819
<211> 2811
<212> DNA
<213> Homo sapiens
<308> NM_004134
<400> 7819

ggcacgagg  gagcgcttg  ttgctgcct  gtactcctc  atttatccg  catgataag  60
gccagccga  ctgcagcag  ccgtctcgt  ggcgccgca  cctcccggg  ccctacggc  120
gcccgccac  aggatagct  gaatggcct  agtcatgag  cttttagac  tgtttcaag  180
cgggattat  catcagaag  aatcaaggg  gcagttgtt  gtattgatt  gggtactac  240
aactcctgc  tggcagtta  ggaaggtaa  cgagcaaag  tgctggaga  tgccgaagg  300
gccagaacc  ccccttcag  tgtggcctt  acagcagat  gtgagcgac  tgttggaat  360
ccggccaag  gacaggctg  caccaaccc  aacaataca  tttatgcta  caagcgtct  420
attggccgg  gatatgatg  tcctgaagt  cagaaagac  ttaaaaatg  tccctttaa  480
attgtccgt  cctccaatg  tgatgcctg  gttgaggct  atgggaaat  gtattctcc  540
agtcagatt  gagcatttg  gttgatgaa  atgaaagag  ctgcagaaa  ttacttggg  600
cgcacagca  aaaatgctg  gatcacagt  ccagcttat  tcaatgact  gcagagaca  660
gccactaaa  atgctggcc  gatatctgg  ctgaatgtg  ttcgggtga  taatgagcc  720
acagctgct  ctcttgcct  tggtctaga  aaatcagaa  acaaagtca  tgctgtata  780
gatttaggt  gtggaactt  tgatatttc  atcctggaa  ttcagaaag  agtatttga  840
gtgaaatcc  caaatgggg  taccttctt  ggtggggaa  actttgacc  ggccttgct  900
cggcacatt  tgaaggagt  caagagaga  acaggggtt  atttgacta  agacaacat  960
gcacttcag  gggtacggg  agctgctga  aaggctaag  gtgaactct  ctcatctgt  1020
cagactgac  tcaatttgc  ctatcttac  atggattct  ctggaccca  gcatttgaa  1080
atgaagttg  cccgtgctc  atttgaagg  attgtcact  atctaatca  aaggactat  1140
gctccatgc  aaaaagcta  gcaagatgc  gaagtcagc  agagtgaca  aggagaagt  1200
attcttgtg  gtggcatga  taggatgcc  aaggttcag  agactgtac  ggatctttt  1260
ggcagagcc  caagtaaag  tgtcaatcc  gatgaggct  tggccattg  agctgccat  1320
cagggaggt  tgttggccg  cgatgtcac  gatgtgctg  tccttgatg  cactcccct  1380
tctctgggt  ttgaaactc  aggaggtgt  tttaccaaa  ttattaata  gaataccac  1440
attccaacc  agaagagcc  ggtattctc  actgccgct  atggtcaaa  gcaagtgga  1500
attaaagtg  gtcagggtg  aagagagat  gctggagac  acaaactcc  tggacagtt  1560
actttgatt  gaattccac  agcccctcg  ggagttcct  agattgaag  tacatttga  1620
attgatgcc  atgggatag  acatgtttc  gctaaagat  aaggcacag  acgtgagca  1680
cagattgta  tccagtctt  tggtggatt  agcaaagat  atattgaaa  tatggttaa  1740
aatgcagag  aatatgctg  agaagaccg  cgaaagaag  aacgagttg  agcagttaa  1800
atggctgaa  gaatcattc  cgacacaga  accaagatg  aagaattca  ggaccaatt  1860
cctgctgat  agtgcaaca  gctgaaaga  gagatttcc  aaatgaggg  gctcctggc  1920
agaaaagac  gcgaaacag  agaaaatat  agacaggca  catcctctc  tcagcaggc  1980
tcattgaag  tgttcgaaa  ggcatacaa  aagatggca  ctgagcgag  aggctctgg  2040
agttctggc  ctggggaac  aaaggaaga  caaaaggag  aaaaacagt  ataatagca  2100
aaattttga  gccagaagg  caacatatg  agcttagga  tgaagagac  tcctgagca  2160
aaatgggcg  acttcagtc  ttttactgt  tttttgcag  attctatat  taatttcct  2220
aatttgtaa  tttagtgac  attagctag  gatcattta  tggacagtg  ttctaacag  2280
ataaagttc  caatattct  tgtccctag  ctgtcattt  tcagctgca  gtaaaagga  2340
gtaggatga  ttgatcatt  taaagattt  actatttta  gctgaagtg  ccatatttt  2400
aaggggtga  accatctcg  acacagcaa  gaaggtagt  atccataga  ttgaaatga  2460
accacatat  gggatgaga  ccttctagt  agcctagta  tgctgtact  gcctgtatg  2520
acatggggt  cttcaactg  ggccttgca  gtcaagctg  ctgtgccat  tttgtagat  2580
gggcagagg  atctagaac  atgggaaac  tagctattt  tattaggta  agctattaa  2640
acaaggtag  aatgaggct  gacctttaa  ttccctaag  catactttt  tagctacct  2700
ctgccctgt  tctggcacc  acatccttg  tgattgttc  cttacccat  ctggaattt  2760
ttttttttt  aaataaata  agaaagcat  ttgaaaaaa  aaaaaaaaa  a  2811



<210> 7820
<211> 679
<212> PRT
<213> Homo sapiens
<308> P38646
<400> 7820

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
  1               5                  10                  15
Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
             20                  25                  30
Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
         35                  40                  45
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
     50                  55                  60
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
 65                  70                  75                  80
Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                 85                  90                  95
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
             100                105                110
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
         115                120                125
Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
     130                135                140
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
 145                150                155                160
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                 165                170                175
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
             180                185                190
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
         195                200                205
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
     210                215                220
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
 225                230                235                240
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                 245                250                255
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
             260                265                270
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
         275                280                285
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
     290                295                300
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
 305                310                315                320
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                 325                330                335
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
             340                345                350
Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
         355                360                365
Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
     370                375                380
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
 385                390                395                400
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                 405                410                415
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
             420                425                430
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
         435                440                445
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
     450                455                460
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
 465                470                475                480
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                 485                490                495
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
             500                505                510
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
         515                520                525
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
     530                535                540
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
 545                550                555                560
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                 565                570                575
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
             580                585                590
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
         595                600                605
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
     610                615                620
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
 625                630                635                640
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                 645                650                655
Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
             660                665                670
Asp Gln Lys Glu Glu Lys Gln 
         675



<210> 7821
<211> 3001
<212> DNA
<213> Rattus norvegicus
<308> S78556
<400> 7821

cggcacgag  gttcttgcc  tcgtagccc  ctgtccagc  gccatgata  gcgccagca  60
agccgcggc  gcgcgtctc  tgggcacca  agcgtcccg  agtcccgcc  ccgcccgtc  120
ccaggatgg  tggaatggc  ttagtcatg  ggcttttag  tttgtttca  gaagggatt  180
tgcgtcaga  gcaatcaag  gtgcagttg  tggaattga  ttgggtact  ctaactcct  240
tgtggctgt  atggagggc  aacaagcca  ggtcctgga  aacgccgaa  gtgccagaa  300
taccccttc  gtggttgcc  ttacaccag  tggggagcg  cttgttggt  tgccagcaa  360
acgacaagc  gtcaccaat  caaacaata  cttctatgc  acaaagcgt  ttattggac  420
acgatatga  gaccctgaa  tacagaaag  cactaagaa  gttcccttt  aaattgtcc  480
tgcctccaa  ggtgatgcc  gggtggagg  tcatggaaa  ctctattct  cgagtcaga  540
tggagcgtt  gtgttgatg  agatgaaag  gactgcaga  aattacttg  gccatacag  600
aaaaaatgc  gtgatcaca  tccctgctt  tttcaatga  tcacagcga  aggccacta  660
ggatgctgg  cagatatct  ggctaaatg  gctccgagt  atcaacgag  ctacagctg  720
agctctggc  tacggtctg  acaaatccg  agacaaagt  attgctgta  atgatttag  780
tggaggaac  tttgacatt  ctatcctgg  aattcagaa  ggagtgttt  aggtgaaat  840
caccaatgg  gacactttc  taggaggtg  agactttga  caagctttg  tacggcaca  900
tgtcaagga  ttcaagagg  agacagggg  tgatttgac  aaagacaac  tggcgcttc  960
gagggttcg  gaagctgct  agaaggcta  atgtgagct  tcctcatct  tacagactg  1020
catcaactt  ccatacctt  caatggatg  ttctggacc  aagcatttg  atatgaagt  1080
gactcgagc  cagtttgaa  gcattgtca  agatctaat  aagagaact  ttgctccgt  1140
tcagaaagc  atgcaggat  cagaagtca  caagagtga  ataggagaa  tgatcctgg  1200
tggtggcat  acgaggatg  ccaaggttc  gcagactgt  caagatctt  ttggcagag  1260
cccaagtaa  gctgttaat  ctgatgagg  tgtagccat  ggagctgcc  ttcaaggag  1320
tgtgttggc  ggtgatgtt  cagatgtgc  actcttgga  gtcactccc  tctctctag  1380
tattgagac  cttggaggt  tctttacca  gcttattaa  aggaacacc  ctattccaa  1440
caaaaagag  caggtattt  ctactgctg  tgatggaca  actcaagta  agattaaag  1500
gtgtcaggg  gaaagagag  tggccggag  caacaaact  ctaggacag  tcactttga  1560
tggaattcc  ccagcccct  gtggagtgc  tcagattga  gttacattt  acattgatg  1620
caatgggat  gtgcacgtt  ctgccaaag  taaagggac  ggacgtgag  aacagattg  1680
aatccagtc  tctggtgga  taagcaaag  tgatattga  aacatggtt  aaaatgcag  1740
gaagtacgc  gaagaagac  ggaggaaga  ggaacgtgt  gaagcagtt  atatggctg  1800
aggaattat  catgacaca  aaaccaaga  ggaagaatt  aaggaccag  tgcctgctg  1860
cgagtgcaa  aagctaaag  aagagattt  caaaatgag  gaactcctt  ctcgaaagg  1920
cagtgaaac  ggagaaaac  ttaggcagg  ggcatcttc  cttcagcag  catcattga  1980
actctttga  atggcatat  aaaagatgg  atctgaacg  gaaggttct  gaagttcta  2040
cactgggga  cagaaggaa  atcagaagg  agagaaaca  taatagtgg  agtgcattg  2100
ggagctagg  cgacatact  tgaagcttg  gagtaaagg  acttcctga  cagaaaagg  2160
gcaaacttc  gtcttttta  tgtattttt  cagtattct  tatataatt  ccttaatat  2220
taaatccag  gacaatata  aaatccagt  acaatagct  taactcatt  aatggtaat  2280
aagtcagca  tagcaggtt  acacttcta  aactagcct  ctgttttca  ctgcacgta  2340
aggggtggg  tggggctgt  taccaatca  tattaggta  atctggttt  tgctgaagt  2400
gctatgttt  cgagatgga  gcccatttc  catgcagta  aggtaatct  tcatggacc  2460
tgaattgag  ttcatatgc  gatgcttgt  gaccaagag  actgctata  atgacctgt  2520
tgtacattt  ctccttcaa  tgatgcctt  caagactaa  ctctctgtg  catggtcta  2580
aggtacaga  gttaggtca  tggataaca  ctgtgttag  catagctta  agtgatcta  2640
caagaatta  acaagcctc  catgggcct  aggcatact  ctccagcta  cctcttggg  2700
ggccaatgt  tgacatcta  attcttgat  attgttcct  tttcatcca  tctggattt  2760
ttttttttt  aataaaatt  tgaaagcct  ttgatctcc  ttgtgaatg  tagtagctc  2820
aggactatg  ctgtaccat  aggtttgtg  gtagaggta  aaaatcaac  ctggctaaa  2880
ggttgaaca  attaaacat  gtgagggac  aaataacat  ttggcatgt  tgctggatg  2940
ggaagccca  tcaggaagc  gtgtgaagc  aggcggggc  acacaatga  acaccccgt  3000
t  3001



<210> 7822
<211> 679
<212> PRT
<213> Rattus norvegicus
<308> AAB34982
<400> 7822

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Thr Thr 
  1               5                  10                  15
Ala Ser Arg Ser Pro Ala Ala Ala Arg His Gln Asp Gly Trp Asn Gly 
             20                  25                  30
Leu Ser His Glu Val Phe Arg Phe Val Ser Arg Arg Asp Tyr Ala Ser 
         35                  40                  45
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
     50                  55                  60
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
 65                  70                  75                  80
Ser Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Pro Asp 
                 85                  90                  95
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
             100                105                110
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
         115                120                125
Asp Asp Pro Glu Val Gln Lys Asp Thr Lys Asn Val Pro Phe Lys Ile 
     130                135                140
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
 145                150                155                160
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                 165                170                175
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
             180                185                190
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
         195                200                205
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
     210                215                220
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
 225                230                235                240
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                 245                250                255
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
             260                265                270
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
         275                280                285
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
     290                295                300
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
 305                310                315                320
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ala 
                 325                330                335
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
             340                345                350
Gly Ile Val Thr Asp Leu Ile Lys Arg Thr Ile Ala Pro Cys Gln Lys 
         355                360                365
Ala Met Gln Asp Arg Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
     370                375                380
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
 385                390                395                400
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                 405                410                415
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
             420                425                430
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
         435                440                445
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
     450                455                460
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
 465                470                475                480
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                 485                490                495
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
             500                505                510
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
         515                520                525
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
     530                535                540
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
 545                550                555                560
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                 565                570                575
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Val His Asp Thr 
             580                585                590
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
         595                600                605
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
     610                615                620
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
 625                630                635                640
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                 645                650                655
Ser Glu Arg Glu Gly Ser Gly Ser Ser Ser Thr Gly Glu Gln Lys Glu 
             660                665                670
Asp Gln Lys Glu Glu Lys Gln 
         675



<210> 7823
<211> 2811
<212> DNA
<213> Homo sapiens
<308> NM_004134
<400> 7823

ggcacgagg  gagcgcttg  ttgctgcct  gtactcctc  atttatccg  catgataag  60
gccagccga  ctgcagcag  ccgtctcgt  ggcgccgca  cctcccggg  ccctacggc  120
gcccgccac  aggatagct  gaatggcct  agtcatgag  cttttagac  tgtttcaag  180
cgggattat  catcagaag  aatcaaggg  gcagttgtt  gtattgatt  gggtactac  240
aactcctgc  tggcagtta  ggaaggtaa  cgagcaaag  tgctggaga  tgccgaagg  300
gccagaacc  ccccttcag  tgtggcctt  acagcagat  gtgagcgac  tgttggaat  360
ccggccaag  gacaggctg  caccaaccc  aacaataca  tttatgcta  caagcgtct  420
attggccgg  gatatgatg  tcctgaagt  cagaaagac  ttaaaaatg  tccctttaa  480
attgtccgt  cctccaatg  tgatgcctg  gttgaggct  atgggaaat  gtattctcc  540
agtcagatt  gagcatttg  gttgatgaa  atgaaagag  ctgcagaaa  ttacttggg  600
cgcacagca  aaaatgctg  gatcacagt  ccagcttat  tcaatgact  gcagagaca  660
gccactaaa  atgctggcc  gatatctgg  ctgaatgtg  ttcgggtga  taatgagcc  720
acagctgct  ctcttgcct  tggtctaga  aaatcagaa  acaaagtca  tgctgtata  780
gatttaggt  gtggaactt  tgatatttc  atcctggaa  ttcagaaag  agtatttga  840
gtgaaatcc  caaatgggg  taccttctt  ggtggggaa  actttgacc  ggccttgct  900
cggcacatt  tgaaggagt  caagagaga  acaggggtt  atttgacta  agacaacat  960
gcacttcag  gggtacggg  agctgctga  aaggctaag  gtgaactct  ctcatctgt  1020
cagactgac  tcaatttgc  ctatcttac  atggattct  ctggaccca  gcatttgaa  1080
atgaagttg  cccgtgctc  atttgaagg  attgtcact  atctaatca  aaggactat  1140
gctccatgc  aaaaagcta  gcaagatgc  gaagtcagc  agagtgaca  aggagaagt  1200
attcttgtg  gtggcatga  taggatgcc  aaggttcag  agactgtac  ggatctttt  1260
ggcagagcc  caagtaaag  tgtcaatcc  gatgaggct  tggccattg  agctgccat  1320
cagggaggt  tgttggccg  cgatgtcac  gatgtgctg  tccttgatg  cactcccct  1380
tctctgggt  ttgaaactc  aggaggtgt  tttaccaaa  ttattaata  gaataccac  1440
attccaacc  agaagagcc  ggtattctc  actgccgct  atggtcaaa  gcaagtgga  1500
attaaagtg  gtcagggtg  aagagagat  gctggagac  acaaactcc  tggacagtt  1560
actttgatt  gaattccac  agcccctcg  ggagttcct  agattgaag  tacatttga  1620
attgatgcc  atgggatag  acatgtttc  gctaaagat  aaggcacag  acgtgagca  1680
cagattgta  tccagtctt  tggtggatt  agcaaagat  atattgaaa  tatggttaa  1740
aatgcagag  aatatgctg  agaagaccg  cgaaagaag  aacgagttg  agcagttaa  1800
atggctgaa  gaatcattc  cgacacaga  accaagatg  aagaattca  ggaccaatt  1860
cctgctgat  agtgcaaca  gctgaaaga  gagatttcc  aaatgaggg  gctcctggc  1920
agaaaagac  gcgaaacag  agaaaatat  agacaggca  catcctctc  tcagcaggc  1980
tcattgaag  tgttcgaaa  ggcatacaa  aagatggca  ctgagcgag  aggctctgg  2040
agttctggc  ctggggaac  aaaggaaga  caaaaggag  aaaaacagt  ataatagca  2100
aaattttga  gccagaagg  caacatatg  agcttagga  tgaagagac  tcctgagca  2160
aaatgggcg  acttcagtc  ttttactgt  tttttgcag  attctatat  taatttcct  2220
aatttgtaa  tttagtgac  attagctag  gatcattta  tggacagtg  ttctaacag  2280
ataaagttc  caatattct  tgtccctag  ctgtcattt  tcagctgca  gtaaaagga  2340
gtaggatga  ttgatcatt  taaagattt  actatttta  gctgaagtg  ccatatttt  2400
aaggggtga  accatctcg  acacagcaa  gaaggtagt  atccataga  ttgaaatga  2460
accacatat  gggatgaga  ccttctagt  agcctagta  tgctgtact  gcctgtatg  2520
acatggggt  cttcaactg  ggccttgca  gtcaagctg  ctgtgccat  tttgtagat  2580
gggcagagg  atctagaac  atgggaaac  tagctattt  tattaggta  agctattaa  2640
acaaggtag  aatgaggct  gacctttaa  ttccctaag  catactttt  tagctacct  2700
ctgccctgt  tctggcacc  acatccttg  tgattgttc  cttacccat  ctggaattt  2760
ttttttttt  aaataaata  agaaagcat  ttgaaaaaa  aaaaaaaaa  a  2811



<210> 7824
<211> 679
<212> PRT
<213> Homo sapiens
<308> P38646
<400> 7824

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
  1               5                  10                  15
Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
             20                  25                  30
Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
         35                  40                  45
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
     50                  55                  60
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
 65                  70                  75                  80
Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                 85                  90                  95
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
             100                105                110
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
         115                120                125
Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
     130                135                140
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
 145                150                155                160
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                 165                170                175
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
             180                185                190
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
         195                200                205
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
     210                215                220
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
 225                230                235                240
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                 245                250                255
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
             260                265                270
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
         275                280                285
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
     290                295                300
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
 305                310                315                320
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                 325                330                335
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
             340                345                350
Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
         355                360                365
Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
     370                375                380
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
 385                390                395                400
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                 405                410                415
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
             420                425                430
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
         435                440                445
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
     450                455                460
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
 465                470                475                480
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                 485                490                495
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
             500                505                510
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
         515                520                525
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
     530                535                540
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
 545                550                555                560
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                 565                570                575
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
             580                585                590
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
         595                600                605
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
     610                615                620
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
 625                630                635                640
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                 645                650                655
Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
             660                665                670
Asp Gln Lys Glu Glu Lys Gln 
         675



<210> 7825
<211> 3001
<212> DNA
<213> Rattus norvegicus
<308> S78556
<400> 7825

cggcacgag  gttcttgcc  tcgtagccc  ctgtccagc  gccatgata  gcgccagca  60
agccgcggc  gcgcgtctc  tgggcacca  agcgtcccg  agtcccgcc  ccgcccgtc  120
ccaggatgg  tggaatggc  ttagtcatg  ggcttttag  tttgtttca  gaagggatt  180
tgcgtcaga  gcaatcaag  gtgcagttg  tggaattga  ttgggtact  ctaactcct  240
tgtggctgt  atggagggc  aacaagcca  ggtcctgga  aacgccgaa  gtgccagaa  300
taccccttc  gtggttgcc  ttacaccag  tggggagcg  cttgttggt  tgccagcaa  360
acgacaagc  gtcaccaat  caaacaata  cttctatgc  acaaagcgt  ttattggac  420
acgatatga  gaccctgaa  tacagaaag  cactaagaa  gttcccttt  aaattgtcc  480
tgcctccaa  ggtgatgcc  gggtggagg  tcatggaaa  ctctattct  cgagtcaga  540
tggagcgtt  gtgttgatg  agatgaaag  gactgcaga  aattacttg  gccatacag  600
aaaaaatgc  gtgatcaca  tccctgctt  tttcaatga  tcacagcga  aggccacta  660
ggatgctgg  cagatatct  ggctaaatg  gctccgagt  atcaacgag  ctacagctg  720
agctctggc  tacggtctg  acaaatccg  agacaaagt  attgctgta  atgatttag  780
tggaggaac  tttgacatt  ctatcctgg  aattcagaa  ggagtgttt  aggtgaaat  840
caccaatgg  gacactttc  taggaggtg  agactttga  caagctttg  tacggcaca  900
tgtcaagga  ttcaagagg  agacagggg  tgatttgac  aaagacaac  tggcgcttc  960
gagggttcg  gaagctgct  agaaggcta  atgtgagct  tcctcatct  tacagactg  1020
catcaactt  ccatacctt  caatggatg  ttctggacc  aagcatttg  atatgaagt  1080
gactcgagc  cagtttgaa  gcattgtca  agatctaat  aagagaact  ttgctccgt  1140
tcagaaagc  atgcaggat  cagaagtca  caagagtga  ataggagaa  tgatcctgg  1200
tggtggcat  acgaggatg  ccaaggttc  gcagactgt  caagatctt  ttggcagag  1260
cccaagtaa  gctgttaat  ctgatgagg  tgtagccat  ggagctgcc  ttcaaggag  1320
tgtgttggc  ggtgatgtt  cagatgtgc  actcttgga  gtcactccc  tctctctag  1380
tattgagac  cttggaggt  tctttacca  gcttattaa  aggaacacc  ctattccaa  1440
caaaaagag  caggtattt  ctactgctg  tgatggaca  actcaagta  agattaaag  1500
gtgtcaggg  gaaagagag  tggccggag  caacaaact  ctaggacag  tcactttga  1560
tggaattcc  ccagcccct  gtggagtgc  tcagattga  gttacattt  acattgatg  1620
caatgggat  gtgcacgtt  ctgccaaag  taaagggac  ggacgtgag  aacagattg  1680
aatccagtc  tctggtgga  taagcaaag  tgatattga  aacatggtt  aaaatgcag  1740
gaagtacgc  gaagaagac  ggaggaaga  ggaacgtgt  gaagcagtt  atatggctg  1800
aggaattat  catgacaca  aaaccaaga  ggaagaatt  aaggaccag  tgcctgctg  1860
cgagtgcaa  aagctaaag  aagagattt  caaaatgag  gaactcctt  ctcgaaagg  1920
cagtgaaac  ggagaaaac  ttaggcagg  ggcatcttc  cttcagcag  catcattga  1980
actctttga  atggcatat  aaaagatgg  atctgaacg  gaaggttct  gaagttcta  2040
cactgggga  cagaaggaa  atcagaagg  agagaaaca  taatagtgg  agtgcattg  2100
ggagctagg  cgacatact  tgaagcttg  gagtaaagg  acttcctga  cagaaaagg  2160
gcaaacttc  gtcttttta  tgtattttt  cagtattct  tatataatt  ccttaatat  2220
taaatccag  gacaatata  aaatccagt  acaatagct  taactcatt  aatggtaat  2280
aagtcagca  tagcaggtt  acacttcta  aactagcct  ctgttttca  ctgcacgta  2340
aggggtggg  tggggctgt  taccaatca  tattaggta  atctggttt  tgctgaagt  2400
gctatgttt  cgagatgga  gcccatttc  catgcagta  aggtaatct  tcatggacc  2460
tgaattgag  ttcatatgc  gatgcttgt  gaccaagag  actgctata  atgacctgt  2520
tgtacattt  ctccttcaa  tgatgcctt  caagactaa  ctctctgtg  catggtcta  2580
aggtacaga  gttaggtca  tggataaca  ctgtgttag  catagctta  agtgatcta  2640
caagaatta  acaagcctc  catgggcct  aggcatact  ctccagcta  cctcttggg  2700
ggccaatgt  tgacatcta  attcttgat  attgttcct  tttcatcca  tctggattt  2760
ttttttttt  aataaaatt  tgaaagcct  ttgatctcc  ttgtgaatg  tagtagctc  2820
aggactatg  ctgtaccat  aggtttgtg  gtagaggta  aaaatcaac  ctggctaaa  2880
ggttgaaca  attaaacat  gtgagggac  aaataacat  ttggcatgt  tgctggatg  2940
ggaagccca  tcaggaagc  gtgtgaagc  aggcggggc  acacaatga  acaccccgt  3000
t  3001



<210> 7826
<211> 679
<212> PRT
<213> Rattus norvegicus
<308> AAB34982
<400> 7826

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Thr Thr 
  1               5                  10                  15
Ala Ser Arg Ser Pro Ala Ala Ala Arg His Gln Asp Gly Trp Asn Gly 
             20                  25                  30
Leu Ser His Glu Val Phe Arg Phe Val Ser Arg Arg Asp Tyr Ala Ser 
         35                  40                  45
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
     50                  55                  60
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
 65                  70                  75                  80
Ser Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Pro Asp 
                 85                  90                  95
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
             100                105                110
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
         115                120                125
Asp Asp Pro Glu Val Gln Lys Asp Thr Lys Asn Val Pro Phe Lys Ile 
     130                135                140
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
 145                150                155                160
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                 165                170                175
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
             180                185                190
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
         195                200                205
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
     210                215                220
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
 225                230                235                240
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                 245                250                255
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
             260                265                270
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
         275                280                285
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
     290                295                300
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
 305                310                315                320
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ala 
                 325                330                335
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
             340                345                350
Gly Ile Val Thr Asp Leu Ile Lys Arg Thr Ile Ala Pro Cys Gln Lys 
         355                360                365
Ala Met Gln Asp Arg Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
     370                375                380
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
 385                390                395                400
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                 405                410                415
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
             420                425                430
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
         435                440                445
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
     450                455                460
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
 465                470                475                480
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                 485                490                495
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
             500                505                510
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
         515                520                525
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
     530                535                540
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
 545                550                555                560
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                 565                570                575
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Val His Asp Thr 
             580                585                590
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
         595                600                605
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
     610                615                620
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
 625                630                635                640
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                 645                650                655
Ser Glu Arg Glu Gly Ser Gly Ser Ser Ser Thr Gly Glu Gln Lys Glu 
             660                665                670
Asp Gln Lys Glu Glu Lys Gln 
         675



<210> 7827
<211> 2811
<212> DNA
<213> Homo sapiens
<308> NM_004134
<400> 7827

ggcacgagg  gagcgcttg  ttgctgcct  gtactcctc  atttatccg  catgataag  60
gccagccga  ctgcagcag  ccgtctcgt  ggcgccgca  cctcccggg  ccctacggc  120
gcccgccac  aggatagct  gaatggcct  agtcatgag  cttttagac  tgtttcaag  180
cgggattat  catcagaag  aatcaaggg  gcagttgtt  gtattgatt  gggtactac  240
aactcctgc  tggcagtta  ggaaggtaa  cgagcaaag  tgctggaga  tgccgaagg  300
gccagaacc  ccccttcag  tgtggcctt  acagcagat  gtgagcgac  tgttggaat  360
ccggccaag  gacaggctg  caccaaccc  aacaataca  tttatgcta  caagcgtct  420
attggccgg  gatatgatg  tcctgaagt  cagaaagac  ttaaaaatg  tccctttaa  480
attgtccgt  cctccaatg  tgatgcctg  gttgaggct  atgggaaat  gtattctcc  540
agtcagatt  gagcatttg  gttgatgaa  atgaaagag  ctgcagaaa  ttacttggg  600
cgcacagca  aaaatgctg  gatcacagt  ccagcttat  tcaatgact  gcagagaca  660
gccactaaa  atgctggcc  gatatctgg  ctgaatgtg  ttcgggtga  taatgagcc  720
acagctgct  ctcttgcct  tggtctaga  aaatcagaa  acaaagtca  tgctgtata  780
gatttaggt  gtggaactt  tgatatttc  atcctggaa  ttcagaaag  agtatttga  840
gtgaaatcc  caaatgggg  taccttctt  ggtggggaa  actttgacc  ggccttgct  900
cggcacatt  tgaaggagt  caagagaga  acaggggtt  atttgacta  agacaacat  960
gcacttcag  gggtacggg  agctgctga  aaggctaag  gtgaactct  ctcatctgt  1020
cagactgac  tcaatttgc  ctatcttac  atggattct  ctggaccca  gcatttgaa  1080
atgaagttg  cccgtgctc  atttgaagg  attgtcact  atctaatca  aaggactat  1140
gctccatgc  aaaaagcta  gcaagatgc  gaagtcagc  agagtgaca  aggagaagt  1200
attcttgtg  gtggcatga  taggatgcc  aaggttcag  agactgtac  ggatctttt  1260
ggcagagcc  caagtaaag  tgtcaatcc  gatgaggct  tggccattg  agctgccat  1320
cagggaggt  tgttggccg  cgatgtcac  gatgtgctg  tccttgatg  cactcccct  1380
tctctgggt  ttgaaactc  aggaggtgt  tttaccaaa  ttattaata  gaataccac  1440
attccaacc  agaagagcc  ggtattctc  actgccgct  atggtcaaa  gcaagtgga  1500
attaaagtg  gtcagggtg  aagagagat  gctggagac  acaaactcc  tggacagtt  1560
actttgatt  gaattccac  agcccctcg  ggagttcct  agattgaag  tacatttga  1620
attgatgcc  atgggatag  acatgtttc  gctaaagat  aaggcacag  acgtgagca  1680
cagattgta  tccagtctt  tggtggatt  agcaaagat  atattgaaa  tatggttaa  1740
aatgcagag  aatatgctg  agaagaccg  cgaaagaag  aacgagttg  agcagttaa  1800
atggctgaa  gaatcattc  cgacacaga  accaagatg  aagaattca  ggaccaatt  1860
cctgctgat  agtgcaaca  gctgaaaga  gagatttcc  aaatgaggg  gctcctggc  1920
agaaaagac  gcgaaacag  agaaaatat  agacaggca  catcctctc  tcagcaggc  1980
tcattgaag  tgttcgaaa  ggcatacaa  aagatggca  ctgagcgag  aggctctgg  2040
agttctggc  ctggggaac  aaaggaaga  caaaaggag  aaaaacagt  ataatagca  2100
aaattttga  gccagaagg  caacatatg  agcttagga  tgaagagac  tcctgagca  2160
aaatgggcg  acttcagtc  ttttactgt  tttttgcag  attctatat  taatttcct  2220
aatttgtaa  tttagtgac  attagctag  gatcattta  tggacagtg  ttctaacag  2280
ataaagttc  caatattct  tgtccctag  ctgtcattt  tcagctgca  gtaaaagga  2340
gtaggatga  ttgatcatt  taaagattt  actatttta  gctgaagtg  ccatatttt  2400
aaggggtga  accatctcg  acacagcaa  gaaggtagt  atccataga  ttgaaatga  2460
accacatat  gggatgaga  ccttctagt  agcctagta  tgctgtact  gcctgtatg  2520
acatggggt  cttcaactg  ggccttgca  gtcaagctg  ctgtgccat  tttgtagat  2580
gggcagagg  atctagaac  atgggaaac  tagctattt  tattaggta  agctattaa  2640
acaaggtag  aatgaggct  gacctttaa  ttccctaag  catactttt  tagctacct  2700
ctgccctgt  tctggcacc  acatccttg  tgattgttc  cttacccat  ctggaattt  2760
ttttttttt  aaataaata  agaaagcat  ttgaaaaaa  aaaaaaaaa  a  2811



<210> 7828
<211> 679
<212> PRT
<213> Homo sapiens
<308> P38646
<400> 7828

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
  1               5                  10                  15
Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
             20                  25                  30
Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
         35                  40                  45
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
     50                  55                  60
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
 65                  70                  75                  80
Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                 85                  90                  95
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
             100                105                110
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
         115                120                125
Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
     130                135                140
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
 145                150                155                160
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                 165                170                175
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
             180                185                190
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
         195                200                205
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
     210                215                220
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
 225                230                235                240
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                 245                250                255
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
             260                265                270
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
         275                280                285
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
     290                295                300
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
 305                310                315                320
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                 325                330                335
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
             340                345                350
Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
         355                360                365
Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
     370                375                380
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
 385                390                395                400
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                 405                410                415
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
             420                425                430
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
         435                440                445
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
     450                455                460
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
 465                470                475                480
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                 485                490                495
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
             500                505                510
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
         515                520                525
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
     530                535                540
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
 545                550                555                560
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                 565                570                575
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
             580                585                590
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
         595                600                605
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
     610                615                620
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
 625                630                635                640
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                 645                650                655
Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
             660                665                670
Asp Gln Lys Glu Glu Lys Gln 
         675



<210> 7829
<211> 987
<212> DNA
<213> Rattus norvegicus
<308> S79304
<400> 7829

gaattccct  tcttcgacc  cgctggagg  ggagaccca  ttctttatc  acacctatt  60
tgattcttc  gccacccag  agtgtacat  ttaattctt  cagggtttg  aattatttc  120
catgtagtt  cctattact  tggaaaaaa  gaacccttc  gatatatag  tatggtatg  180
gccataata  ctattggct  cctaggatt  attgtatga  cacatcaca  attcacagt  240
ggcctagat  tagacaccc  agcctactt  acatctgcc  ctataatta  cgcaattcc  300
acaggcgta  aagtattca  ctgactcgc  acactacat  gaggaaata  caaatgatc  360
cccgccata  tatgagcct  agggtttat  ttcttattc  cagtagggg  cctaacagg  420
atcgtacta  ctaactcat  ccttgacat  gtacttcat  atacatact  cgtagtagc  480
cacttccac  atgtcttat  tataggagc  gtattcgcc  tcatagctt  cttcgtcca  540
tgattccca  tattctcag  ctataccct  aatgacaca  gagcaaaag  ccactttgc  600
attatattt  taggtgtaa  cataacatt  tttcctcaa  acttcctag  attagcagg  660
atacctcgt  gttactctg  ttatccaga  gcttatacc  catgaaata  agtctcctc  720
ataggctca  tcatctcac  tacggccgt  cttgtaatg  tcttcatga  ttgagaagc  780
ttcgcatca  aacgagaag  gctctcaat  tcctactct  caactaacc  agaatgact  840
catggatgc  ccccacctt  ccacacatt  gaagaacct  cctatgtaa  agttaaata  900
gaaaggaag  attcgaacc  cctacaact  gtttcaagc  aatttcata  ccattatgt  960
tttctcaat  aaaaaaaaa  ggaattc  987



<210> 7830
<211> 514
<212> PRT
<213> Rattus norvegicus
<308> AAB21298
<400> 7830

Met Phe Val Asn Arg Trp Leu Phe Ser Thr Asn His Lys Asp Ile Gly 
  1               5                  10                  15
Thr Leu Tyr Leu Leu Phe Gly Ala Trp Ala Gly Met Val Gly Thr Ala 
             20                  25                  30
Leu Ser Ile Leu Ile Arg Ala Glu Leu Gly Gln Pro Gly Ala Leu Leu 
         35                  40                  45
Gly Asp Asp Gln Ile Tyr Asn Val Ile Val Thr Ala His Ala Phe Val 
     50                  55                  60
Met Ile Phe Phe Met Val Met Pro Met Met Ile Gly Gly Phe Gly Asn 
 65                  70                  75                  80
Trp Leu Val Pro Leu Met Ile Gly Ala Pro Asp Met Ala Phe Pro Arg 
                 85                  90                  95
Met Asn Asn Met Ser Phe Trp Leu Leu Pro Pro Ser Phe Leu Leu Leu 
             100                105                110
Leu Ala Ser Ser Met Val Glu Ala Gly Ala Gly Thr Gly Trp Thr Val 
         115                120                125
Tyr Pro Pro Leu Ala Gly Asn Leu Ala His Ala Gly Val Ser Val Asp 
     130                135                140
Leu Thr Ile Phe Ser Leu His Leu Ala Gly Val Ser Ser Ile Leu Gly 
 145                150                155                160
Ala Ile Asn Phe Ile Thr Thr Ile Ile Asn Met Lys Pro Pro Ala Met 
                 165                170                175
Thr Gln Tyr Gln Thr Pro Leu Phe Val Trp Ser Val Leu Ile Thr Ala 
             180                185                190
Val Leu Leu Leu Leu Ser Leu Pro Val Leu Ala Ala Gly Ile Thr Met 
         195                200                205
Leu Leu Thr Asp Arg Asn Leu Asn Thr Thr Phe Phe Asp Pro Ala Gly 
     210                215                220
Gly Gly Asp Pro Ile Leu Tyr Gln His Leu Phe Trp Phe Phe Gly His 
 225                230                235                240
Pro Glu Val Tyr Ile Leu Ile Leu Pro Gly Phe Gly Ile Ile Ser His 
                 245                250                255
Val Val Thr Tyr Tyr Ser Gly Lys Lys Glu Pro Phe Gly Tyr Met Gly 
             260                265                270
Met Val Trp Thr Met Met Ser Ile Gly Phe Leu Gly Phe Ile Val Trp 
         275                280                285
Ala His His Met Phe Thr Val Gly Leu Asp Val Asp Thr Arg Ala Tyr 
     290                295                300
Phe Thr Ser Ala Thr Met Ile Ile Ala Ile Pro Thr Gly Val Lys Val 
 305                310                315                320
Phe Ser Trp Leu Ala Thr Leu His Gly Gly Asn Ile Lys Trp Ser Pro 
                 325                330                335
Ala Met Leu Trp Ala Leu Gly Phe Ile Phe Leu Phe Thr Val Gly Gly 
             340                345                350
Leu Thr Gly Ile Val Leu Ser Asn Ser Ser Leu Asp Ile Val Leu His 
         355                360                365
Asp Thr Tyr Tyr Val Val Ala His Phe His Tyr Val Leu Ser Met Gly 
     370                375                380
Ala Val Phe Ala Ile Met Ala Gly Phe Val His Trp Phe Pro Leu Phe 
 385                390                395                400
Ser Gly Tyr Thr Leu Asn Asp Thr Trp Ala Lys Ala His Phe Ala Ile 
                 405                410                415
Met Phe Val Gly Val Asn Met Thr Phe Phe Pro Gln His Phe Leu Gly 
             420                425                430
Leu Ala Gly Met Pro Arg Arg Tyr Ser Asp Tyr Pro Asp Ala Tyr Thr 
         435                440                445
Thr Trp Asn Thr Val Ser Ser Met Gly Ser Phe Ile Ser Leu Thr Ala 
     450                455                460
Val Leu Val Met Ile Phe Met Ile Trp Glu Ala Phe Ala Ser Lys Arg 
 465                470                475                480
Glu Val Leu Ser Ile Ser Tyr Ser Ser Thr Asn Leu Glu Trp Leu His 
                 485                490                495
Gly Cys Pro Pro Pro Tyr His Thr Phe Glu Glu Pro Ser Tyr Val Lys 
             500                505                510
Val Lys 
         515



<210> 7831
<211> 1580
<212> DNA
<213> Rattus norvegicus
<308> S79523
<400> 7831

acattcttc  tgagtgcag  acaccctcc  tgtgcaaga  cacagcgcc  caggtgcag  60
agactgagg  ccgcagaag  acttacaga  gagacccag  aagccatgg  gtttccatg  120
agatgtcag  gtgctcagc  gggctcctg  agcttcctg  agctgtgga  ctggacact  180
ctgtgttgt  atctcctgc  acaccatgg  actcactgt  ggacttacc  ttattctga  240
agatccatg  actgggaaa  tgctagaaa  ttctgcaag  acaattaca  agatttagt  300
gctatacaa  ataagagag  aattgagta  ttggaaaag  cattaccca  aaaccctac  360
tactactgg  taggaatca  gaaaatcgg  aaaacgtgg  catgggtgg  aaccaacaa  420
accctcacc  aagaagcag  gaactgggg  actggggag  ccaacaaca  gaagtctaa  480
gaagactgc  tggagatct  tatcaagag  gaacgagac  ctgggaagt  gaatgacga  540
gcctgccac  aacgaaagg  agctctctg  tacacagcc  cctgccaac  agaatcttg  600
aaccgccat  gagaatgtg  ggaaactat  aacaataac  cctgcatct  tgacccagg  660
tattatggg  cccagtgtc  gtatgtgat  caatgtgag  ctttgaagg  ccctgagct  720
ggtaccatg  actgtattc  ccccttggg  gacttcagc  tccagtcac  gtgtgcttt  780
aactgttct  agggaagcg  gctacttgg  aatgcaaaa  cagagtgtg  agcatctgg  840
aactggaca  atctagagc  aatctgtca  gtgattcag  gcatgcctc  agcagcacc  900
gatctgggc  ctatggaat  cagtcaccc  ctcgccaac  tcagtttta  ttctgcttg  960
accttcacc  gctcagaag  aactgactt  attggggag  gaaaaactg  ctgcagatc  1020
tctggctcc  ggtctagtc  tagtccaat  tgtcaaaag  caaagagaa  tttctcaaa  1080
atcaaggaa  gcgactata  ccccctctt  attccagta  ctgtcatgg  cactgcatt  1140
tcagggctg  catttatca  ttggctggc  aggcggcta  aaaaaggca  gaaatcgca  1200
gaaaggatg  atgatcctt  ctgattgat  ctttgtgag  ggaaagtca  aaggtacta  1260
caaccgcca  caaaaacca  tggaagaca  cttcaacac  tcctgttaa  attttgcac  1320
cgggcatct  ccacgttag  gatgcagtg  ttgctcagt  taactgagt  cggatttca  1380
cacgaccaa  agctcctcc  aatttcctc  cactcactc  tcctataaa  ctattccat  1440
acttgtgct  atacagatc  gtattttat  atcttttct  tgaaagaac  aataagaca  1500
ttgagcaaa  gagttactg  aggatataa  gatacctgc  tttactctt  cccaactct  1560
gtttcctct  tcagtgccaa  1580



<210> 7832
<211> 372
<212> PRT
<213> Rattus norvegicus
<308> P30836
<400> 7832

Met Val Phe Pro Trp Arg Cys Gln Ser Ala Gln Arg Gly Ser Trp Ser 
  1               5                  10                  15
Phe Leu Lys Leu Trp Ile Arg Thr Leu Leu Cys Cys Asp Leu Leu Pro 
             20                  25                  30
His His Gly Thr His Cys Trp Thr Tyr His Tyr Ser Glu Arg Ser Met 
         35                  40                  45
Asn Trp Glu Asn Ala Arg Lys Phe Cys Lys His Asn Tyr Thr Asp Leu 
     50                  55                  60
Val Ala Ile Gln Asn Lys Arg Glu Ile Glu Tyr Leu Glu Lys Thr Leu 
 65                  70                  75                  80
Pro Lys Asn Pro Thr Tyr Tyr Trp Ile Gly Ile Arg Lys Ile Gly Lys 
                 85                  90                  95
Thr Trp Thr Trp Val Gly Thr Asn Lys Thr Leu Thr Lys Glu Ala Glu 
             100                105                110
Asn Trp Gly Thr Gly Glu Pro Asn Asn Lys Lys Ser Lys Glu Asp Cys 
         115                120                125
Val Glu Ile Tyr Ile Lys Arg Glu Arg Asp Ser Gly Lys Trp Asn Asp 
     130                135                140
Asp Ala Cys His Lys Arg Lys Ala Ala Leu Cys Tyr Thr Ala Ser Cys 
 145                150                155                160
Gln Pro Glu Ser Cys Asn Arg His Gly Glu Cys Val Glu Thr Ile Asn 
                 165                170                175
Asn Asn Thr Cys Ile Cys Asp Pro Gly Tyr Tyr Gly Pro Gln Cys Gln 
             180                185                190
Tyr Val Ile Gln Cys Glu Pro Leu Lys Ala Pro Glu Leu Gly Thr Met 
         195                200                205
Asn Cys Ile His Pro Leu Gly Asp Phe Ser Phe Gln Ser Gln Cys Ala 
     210                215                220
Phe Asn Cys Ser Glu Gly Ser Glu Leu Leu Gly Asn Ala Lys Thr Glu 
 225                230                235                240
Cys Gly Ala Ser Gly Asn Trp Thr Tyr Leu Glu Pro Ile Cys Gln Val 
                 245                250                255
Ile Gln Cys Met Pro Leu Ala Ala Pro Asp Leu Gly Thr Met Glu Cys 
             260                265                270
Ser His Pro Leu Ala Asn Phe Ser Phe Thr Ser Ala Cys Thr Phe Thr 
         275                280                285
Cys Ser Glu Glu Thr Asp Leu Ile Gly Glu Arg Lys Thr Val Cys Arg 
     290                295                300
Ser Ser Gly Ser Trp Ser Ser Pro Ser Pro Ile Cys Gln Lys Thr Lys 
 305                310                315                320
Arg Ser Phe Ser Lys Ile Lys Glu Gly Asp Tyr Asn Pro Leu Phe Ile 
                 325                330                335
Pro Val Ala Val Met Val Thr Ala Phe Ser Gly Leu Ala Phe Ile Ile 
             340                345                350
Trp Leu Ala Arg Arg Leu Lys Lys Gly Lys Lys Ser Gln Glu Arg Met 
         355                360                365
Asp Asp Pro Tyr 
     370



<210> 7833
<211> 1924
<212> DNA
<213> Rattus norvegicus
<308> S80376
<400> 7833

gagcctcct  gagtacctc  tccctgata  aatatgcgt  atccgagtc  tcactcgcc  60
gggagcctg  aggtcgtcg  agctgtgcg  ggagcgcgt  cccatacgc  ctggggcgc  120
gggtgcaag  aagccacgc  ggtcagcgt  taagcaagc  ccccttgtc  ctcctctga  180
tcatcaggt  agggaaacg  tcctctgag  ccccaagcc  acccctacc  cagttccca  240
ctccttcca  gagagcggg  cccgcaagg  gcgcgcaca  cagacagca  agcaacgag  300
cggcccaca  tcgccttgt  gggactctt  ggtacgaac  ctggccctt  gtgctgtgc  360
tagccacta  gaggggcag  accctgctt  tggttgcgc  ccaactccc  ctcagcatc  420
ccgtggggc  gtgctgagc  aggagctgg  tgagcccgg  cacagcgcc  ccccgctgt  480
tccagcaga  cccggcgcc  ggggggttc  gtcgctgtg  gctgtttcc  cagcaggtt  540
ctaagacga  ctgccttta  ggagcgttt  cctgggcgc  cctcgctcc  ggcgccgtt  600
gccgggagc  tgcggtggg  aagggaggg  gaagccggt  cgatcgtag  tccccggga  660
acctggccg  ctctttcag  atcagacag  ggagaagcc  tcgcgggag  cacttatcg  720
ggtctcgct  gctctggtg  gccttccta  ttgcctgat  ggagtgcga  ccagcaggc  780
tggggtgtt  gggcaacag  agcaagacc  cggaagatc  gggcgtgga  gaaaaggaa  840
gccgggagg  caacaaaaa  atcgagaag  agttgcaga  agagcgcct  gcttacaaa  900
cgacccacc  cctgctgct  ctgggggct  gtgagtccg  gaaaagcac  atagtcaaa  960
agatgagga  cctacacgt  aatggctcc  accccgagg  aaagaagca  aaaattctg  1020
acatcagga  aaatgtcaa  gatgctatt  tgacaatcg  ttcagcaat  agtaccata  1080
tacctccag  tccactggc  aaccctgag  accagtttc  gtcagatta  atcaagagc  1140
tagccccta  cactgactt  gaatattcc  aggagttct  tgaccacgt  aagaagctg  1200
gggatgatg  aggagtgaa  gcctgcttt  agagatcca  cgagtacca  ctgatcgac  1260
gtgcacaat  cttcctgga  aggattgac  gcgtgagtc  ggttgacta  acacccaca  1320
accaggacc  actcagatg  agagtgctg  catcaggga  ctttgagac  cgattccaa  1380
tggacaaag  gaactttca  atgtttgac  ttggaggcc  gagggatga  agaagaaaa  1440
ggatccagt  ttttaacga  gtcactgcc  tcatctatg  ggcagcctg  agcagctac  1500
acatggtga  ccgggaaga  aacaacacc  acagactcc  ggagtcgct  gacctgttt  1560
aaagcatct  gaataacag  tggttacga  ccatttcca  catcctgtt  ttgaacaaa  1620
aagatatgc  ggcagaaaa  gtcttggcc  ggaagtcaa  aattgaaga  tatttcccg  1680
agtatgcca  ctatactgt  cctgaagat  caacaccag  tgcaggaga  gatcccaaa  1740
ttacaagag  caagttctt  atccgggat  tgttcttga  gatcagcac  gccacgggt  1800
atggcaaac  ttactgcta  cctcacttc  cctgcgccg  ggacacaga  aacatccgc  1860
gagtgttca  cgattgtcg  gacatcatc  agagaatgc  cctcaagca  tacgaactc  1920
tgtg  1924



<210> 7834
<211> 381
<212> PRT
<213> Rattus norvegicus
<308> P38406
<400> 7834

Met Gly Cys Leu Gly Asn Ser Ser Lys Thr Ala Glu Asp Gln Gly Val 
  1               5                  10                  15
Asp Glu Lys Glu Arg Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu 
             20                  25                  30
Gln Lys Glu Arg Leu Ala Tyr Lys Ala Thr His Arg Leu Leu Leu Leu 
         35                  40                  45
Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile 
     50                  55                  60
Leu His Val Asn Gly Ser Asn Pro Glu Glu Lys Lys Gln Lys Ile Leu 
 65                  70                  75                  80
Asp Ile Arg Lys Asn Val Lys Asp Ala Ile Val Thr Ile Val Ser Ala 
                 85                  90                  95
Met Ser Thr Ile Ile Pro Pro Val Pro Leu Ala Asn Pro Glu Asn Gln 
             100                105                110
Phe Arg Ser Asp Tyr Ile Lys Ser Ile Ala Pro Ile Thr Asp Phe Glu 
         115                120                125
Tyr Ser Gln Glu Phe Phe Asp His Val Lys Lys Leu Trp Asp Asp Glu 
     130                135                140
Gly Val Lys Ala Cys Phe Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp 
 145                150                155                160
Cys Ala Gln Tyr Phe Leu Glu Arg Ile Asp Ser Val Ser Leu Val Asp 
                 165                170                175
Tyr Thr Pro Thr Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser 
             180                185                190
Gly Ile Phe Glu Thr Arg Phe Gln Val Asp Lys Val Asn Phe His Met 
         195                200                205
Phe Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys 
     210                215                220
Phe Asn Asp Val Thr Ala Ile Ile Tyr Val Ala Ala Cys Ser Ser Tyr 
 225                230                235                240
Asn Met Val Ile Arg Glu Asp Asn Asn Thr Asn Arg Leu Arg Glu Ser 
                 245                250                255
Leu Asp Leu Phe Glu Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile 
             260                265                270
Ser Ile Ile Leu Phe Leu Asn Lys Gln Asp Met Leu Ala Glu Lys Val 
         275                280                285
Leu Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Tyr Ala Asn 
     290                295                300
Tyr Thr Val Pro Glu Asp Ala Thr Pro Asp Ala Gly Glu Asp Pro Lys 
 305                310                315                320
Val Thr Arg Ala Lys Phe Phe Ile Arg Asp Leu Phe Leu Arg Ile Ser 
                 325                330                335
Thr Ala Thr Gly Asp Gly Lys His Tyr Cys Tyr Pro His Phe Thr Cys 
             340                345                350
Ala Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp 
         355                360                365
Ile Ile Gln Arg Met His Leu Lys Gln Tyr Glu Leu Leu 
     370                375                380



<210> 7835
<211> 2092
<212> DNA
<213> Homo sapiens
<308> L10665
<400> 7835

ctctaaagc  attctcgtg  aaaaaggca  tttactccg  gcgtcttcc  tacagccat  60
tagttggga  tttgcggtg  gcaggggga  ggagaagaa  cgcctgctc  gaatcggaa  120
acaccgaag  gaccagacc  tctctttca  cagcaggaa  gagaggagc  gtcgcagga  180
ccgcacacg  ctccaactc  ctattgctt  ttgcgcaca  tcctaactt  ctgacgtcc  240
tcccagcgg  caggcatgg  gtgtttggg  ggcaacagc  agacgacgg  agaccaggg  300
gtcgatgaa  aagaacgac  cgaggccaa  aaaaagatc  agaagcagt  gcagaaaga  360
cgcctggct  acaaggcta  ccaccgcct  ctgctcctg  gggctggtg  gtctgggaa  420
agcaccatc  tcaaacaga  gaggatcct  cacgtcaat  ggtttaatc  cgaggaaaa  480
aaacagaaa  ttctggaca  ccggaaaaa  gttaaagat  ctatcgtga  aattgtttc  540
gcaatgagt  ctataatac  tccagttcc  ctggccaac  ctgaaaacc  atttcgatc  600
gactacatc  agagcatag  ccctatcac  gactttgaa  attcccagg  attctttga  660
catgtgaaa  aactttggg  cgatgaagg  gtgaaggca  gctttgaga  atccaacga  720
taccagctg  ttgactgtg  acaatactt  ctggaaaga  tcgacagcg  cagcttggt  780
gactacaca  ccacagacc  ggacctcct  agatgcaga  ttctgacat  tgggatttt  840
gagacacga  tccaagtgg  caaagtaaa  ttccacatg  ttgatgttg  tggccagag  900
gatgagagg  gaaaatgga  ccagtgctt  aacgatgtc  cagctatca  ttacgtcgc  960
gcctgcagt  gctacaaca  ggtgattcg  gaagataac  acaccaaca  gctgagaga  1020
tccctggat  tttttgaaa  catctggaa  aacaggtgg  tacggacca  ttctatcat  1080
ttgttcttg  acaaacaag  tatgctggc  gaaaaagtc  tggcaggga  atcaaaaat  1140
gaagactat  tcccagaat  tgcaaatta  actgttcct  aagacgcaa  accagatgc  1200
ggagaagat  ccaaagtta  aagagccaa  ttctttatc  gggacctgt  tttgaggat  1260
agcacggcc  ccggtgacg  caaacatta  tgctacccg  acttcacct  cgccgtgga  1320
acagagaac  tccgcaggg  gttcaacga  tgccgcgac  tcatccagc  gatgcacct  1380
aagcagtat  agctcttgt  aggacttgg  cgccaccct  cgacggagc  gcgcccccg  1440
actgcctga  tgccagccc  atgccatgg  aggaggcag  gtctctagt  ccatctcgc  1500
gccgtctgt  ccgttctgt  tcgaccacc  agcctctgg  tacctctgt  ccctcaggt  1560
tggttgtgt  gcttctgtt  tcattgaat  cggcttccc  cagcatccc  cccccaaac  1620
accgactct  attgccgac  ctgcagcag  atctctccg  gtgggagcc  aattattca  1680
tctcccttt  ttgattcat  gaggagaac  tggtagatg  ggagaaaaa  acagttggt  1740
tttttttcc  cgttatcaa  cgtgactgc  agagcgttc  tgcatgccc  gagccacgg  1800
cgtctctga  tctcccttt  tgaagctgc  ggctgacga  agatggtcc  ttcccattg  1860
cttagccca  gacttggag  cgaccccaa  cgacagagt  accagaaac  cttttacag  1920
cacattcag  gtcgctgct  gcctcaggc  tttgaatta  agctacttt  agcctctta  1980
gcagaaaac  taccacatt  actactgca  aatgtgtcc  gtctaaaaa  gattctcta  2040
actttccct  tacttaggc  tagtcttct  tcttagatt  tctttgttg  tg  2092



<210> 7836
<211> 381
<212> PRT
<213> Homo sapiens
<308> P38405
<400> 7836

Met Gly Cys Leu Gly Gly Asn Ser Lys Thr Thr Glu Asp Gln Gly Val 
  1               5                  10                  15
Asp Glu Lys Glu Arg Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu 
             20                  25                  30
Gln Lys Glu Arg Leu Ala Tyr Lys Ala Thr His Arg Leu Leu Leu Leu 
         35                  40                  45
Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile 
     50                  55                  60
Leu His Val Asn Gly Phe Asn Pro Glu Glu Lys Lys Gln Lys Ile Leu 
 65                  70                  75                  80
Asp Ile Arg Lys Asn Val Lys Asp Ala Ile Val Thr Ile Val Ser Ala 
                 85                  90                  95
Met Ser Thr Ile Ile Pro Pro Val Pro Leu Ala Asn Pro Glu Asn Gln 
             100                105                110
Phe Arg Ser Asp Tyr Ile Lys Ser Ile Ala Pro Ile Thr Asp Phe Glu 
         115                120                125
Tyr Ser Gln Glu Phe Phe Asp His Val Lys Lys Leu Trp Asp Asp Glu 
     130                135                140
Gly Val Lys Ala Cys Phe Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp 
 145                150                155                160
Cys Ala Gln Tyr Phe Leu Glu Arg Ile Asp Ser Val Ser Leu Val Asp 
                 165                170                175
Tyr Thr Pro Thr Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser 
             180                185                190
Gly Ile Phe Glu Thr Arg Phe Gln Val Asp Lys Val Asn Phe His Met 
         195                200                205
Phe Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys 
     210                215                220
Phe Asn Asp Val Thr Ala Ile Ile Tyr Val Ala Ala Cys Ser Ser Tyr 
 225                230                235                240
Asn Met Val Ile Arg Glu Asp Asn Asn Thr Asn Arg Leu Arg Glu Ser 
                 245                250                255
Leu Asp Leu Phe Glu Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile 
             260                265                270
Ser Ile Ile Leu Phe Leu Asn Lys Gln Asp Met Leu Ala Glu Lys Val 
         275                280                285
Leu Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Tyr Ala Asn 
     290                295                300
Tyr Thr Val Pro Glu Asp Ala Thr Pro Asp Ala Gly Glu Asp Pro Lys 
 305                310                315                320
Val Thr Arg Ala Lys Phe Phe Ile Arg Asp Leu Phe Leu Arg Ile Ser 
                 325                330                335
Thr Ala Thr Gly Asp Gly Lys His Tyr Cys Tyr Pro His Phe Thr Cys 
             340                345                350
Ala Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp 
         355                360                365
Ile Ile Gln Arg Met His Leu Lys Gln Tyr Glu Leu Leu 
     370                375                380



<210> 7837
<211> 3144
<212> DNA
<213> Rattus norvegicus
<308> S81497
<400> 7837

ccgtgactg  agaagccat  gccaagggt  tcgcaggat  gttgctgtc  caggtgctg  60
agactgagg  tgaaggact  ccccggaga  ggctgcagt  gttcggttc  tgtctcttc  120
gtgtaggat  tgatttctc  taaacttgg  ttaagactt  taaagaagg  cctaattta  180
cgaggcctg  ttgtgaagt  aaattcggc  ggctactct  aacggaaga  agatgcaac  240
gctaggccg  gtgatctgt  tcgtcgttg  gatcctgct  tctgggggc  caacgggga  300
catatcagc  gtggaccct  aagcaaaca  gaatgtgac  gagataatc  tgcactggg  360
atatccaga  cactcagta  agacaggag  tggctacat  ctgggtgtt  accgaatcc  420
gcatgggcg  aagaaccag  ttgataaag  tcccaaacc  gttgtgtat  ttcagtggc  480
acatggctt  ctggcagat  ctagtaact  ggtcacaaa  attgacaac  acagcctgg  540
cttcatcct  gcagatgct  gctttgatg  gtggatggg  aacagcaga  gaaacacct  600
gtctcggaa  cacaagact  tgtcagttt  tcaggatga  tactgggcc  tcagttttg  660
tgagatggc  aaatatgac  tccctgctt  aattaacta  attttgaat  aaactggcc  720
agaacagct  tataatgtg  gccactctc  aggctgcac  ataggtttt  tagcatttt  780
acagatgcc  gaactggca  agaaggtta  aatgttttt  gccctggct  ctgtgttgt  840
tctcaattt  gcttcgggc  cgatggtca  attgggacg  ttgccggat  tgcttcttg  900
ggacttgtt  gggcagaag  aatttcttc  tcagagtgc  atggtgaaa  ggctaagca  960
tcacatttg  acgcacgtc  tcatgaagg  gctttgcgc  aacatcttc  ttctgatat  1020
tggcttcaa  gagaagaat  taaacatgt  tagagtgga  gtgtataca  cacactgtc  1080
tgcgggaac  tctgtgcaa  acatggtac  ctggaccca  gttgttaaa  accataagc  1140
tcaagcttt  gactgggga  gcagtgaca  gaattattt  cattacaat  agagttatc  1200
acccttgta  agcataaaa  acatgcaac  acccactgc  ttatggagc  ggggcaagg  1260
ctggctggc  gacaccagt  acatcaata  cttactgac  gaaatcccc  cgttagtgt  1320
ccacaagaa  attcccgag  gggaccatc  ggattttat  tggggtttg  atgccccct  1380
gaggctgta  aatgaagta  tcagtctaa  gaagaaata  cagtgagtg  caagacttg  1440
gatgcttcc  cttcactag  ggaaaaaag  acagatgtt  gcttaattc  tgcaaaata  1500
tgtgttttc  tggtctaga  catttgtat  ttttatgtg  aagaaaacg  tgatgttga  1560
gacatacat  ggtctggtc  gtaagaagc  cgctggctg  cttctgctt  attctgact  1620
acaagccag  gtcacaacc  gtgatgcct  tgaagtttt  agaaagtat  ggtgttacg  1680
gaaagaagc  attgcaacc  cttgtttac  ttttacggt  gttttcggt  tctgcatgc  1740
gtgcatata  atgcctatg  gtgtgccct  tgctggcca  agcctcctt  tgtggaggt  1800
atggctcac  tcagggtat  ttccctcag  cactggtct  tcgacgaac  agtcagtag  1860
ttgctattc  agttagact  gctgaccag  gagcctcca  aatctgtcc  tctctacct  1920
ccctcacca  gtctacgga  ggtgatgtc  cagccagca  tttacactg  ttctaggga  1980
aggaactca  gttctcatg  ttgatagca  gccctttct  caccaaacc  ttgcctcaa  2040
ccctctgtg  tcgaaaagc  gctcaatta  ctttatgtt  ccacccaat  caagtgaac  2100
agcacaaga  atttcaagc  gttgtttgt  agctaaaaa  caatctgcc  gtgacttga  2160
catgctagg  agaaactcc  ggccctgag  ttgacaaac  tgcagtcca  gttctccag  2220
gattgagac  gggaggctg  tgttacatt  agggttcat  tggagagtg  gactttgtc  2280
ctacaaaac  aaagacaaa  gagaagaag  aaaaaaaaa  cctaaagta  tcagttctc  2340
tctgttagc  tcagagggc  tagagagtt  ctgtgttta  ctatccgaa  aacattttc  2400
tgtctttat  cagtagcta  ctagtgaaa  ccagtgtta  cccagcttc  ccaggcgta  2460
acattctct  ttcaatctc  tcagacctc  gtagcaagc  tttagtgaa  atttagatt  2520
ttcaggcca  gccaagaca  aaatgaata  aataaaaga  aaaagagcc  agactcttg  2580
aagcggttt  cactgattt  aaaataaaa  aaaagaatc  tgaagaatg  catgataaa  2640
tgtgttggt  ccgcatgtg  agtcggatc  cttttctgt  gagaacgtt  tgtggaggg  2700
caaaccact  atttgcccc  agtgaatgt  gctgtagtg  cagcgacag  gcctctgat  2760
ctgagaagc  gggctggct  ccggtgaca  gcatcccag  tcctttccc  agagatgaa  2820
aggatgttt  cagacagag  tcggctcag  gaatttcgc  tggagaatc  gtggtttat  2880
tgcacaatg  tttagtgag  ctgctctgc  cctgatatg  ggaagccct  gactgttca  2940
cgggctcgt  ggcgacggc  gccgtcagc  ggacagtgg  taagttttc  gagtagtca  3000
cacagattc  gggatatcg  tttgtgtcg  ctcctaagg  aggcaggac  atatgactt  3060
gtaacattg  aaaggttca  atttaaact  ttcaataaa  ctcagcctc  caggcctga  3120
catcaaaaa  aaaaaaaaa  aaaa  3144



<210> 7838
<211> 397
<212> PRT
<213> Rattus norvegicus
<308> AAB36043
<400> 7838

Met Gln Leu Leu Gly Arg Val Ile Cys Phe Val Val Gly Ile Leu Leu 
  1               5                  10                  15
Ser Gly Gly Pro Thr Gly Thr Ile Ser Ala Val Asp Pro Glu Ala Asn 
             20                  25                  30
Met Asn Val Thr Glu Ile Ile Met His Trp Gly Tyr Pro Glu His Ser 
         35                  40                  45
Val Gln Thr Gly Asp Gly Tyr Ile Leu Gly Val His Arg Ile Pro His 
     50                  55                  60
Gly Arg Lys Asn Gln Phe Asp Lys Gly Pro Lys Pro Val Val Tyr Leu 
 65                  70                  75                  80
Gln Trp Arg His Gly Phe Leu Ala Asp Ser Ser Asn Trp Val Thr Asn 
                 85                  90                  95
Ile Asp Asn Asn Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp 
             100                105                110
Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys 
         115                120                125
Thr Leu Ser Val Ser Gln Asp Glu Tyr Trp Ala Phe Ser Phe Asp Glu 
     130                135                140
Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Tyr Ile Leu Asn Lys 
 145                150                155                160
Thr Gly Gln Glu Gln Leu Tyr Asn Val Gly His Ser Gln Gly Cys Thr 
                 165                170                175
Ile Gly Phe Ile Ala Phe Ser Gln Met Pro Glu Leu Ala Lys Lys Val 
             180                185                190
Lys Met Phe Phe Ala Leu Ala Pro Val Leu Ser Leu Asn Phe Ala Ser 
         195                200                205
Gly Pro Met Val Lys Leu Gly Arg Leu Pro Asp Leu Leu Leu Glu Asp 
     210                215                220
Leu Phe Gly Gln Lys Gln Phe Leu Pro Gln Ser Ala Met Val Lys Trp 
 225                230                235                240
Leu Ser Thr His Ile Cys Thr His Val Ile Met Lys Glu Leu Cys Ala 
                 245                250                255
Asn Ile Phe Phe Leu Ile Cys Gly Phe Asn Glu Lys Asn Leu Asn Met 
             260                265                270
Ser Arg Val Asp Val Tyr Thr Thr His Cys Pro Ala Gly Thr Ser Val 
         275                280                285
Gln Asn Met Val His Trp Thr Gln Val Val Lys Tyr His Lys Leu Gln 
     290                295                300
Ala Phe Asp Trp Gly Ser Ser Asp Lys Asn Tyr Phe His Tyr Asn Gln 
 305                310                315                320
Ser Tyr Pro Pro Leu Tyr Ser Ile Lys Asp Met Gln Leu Pro Thr Ala 
                 325                330                335
Leu Trp Ser Gly Gly Lys Asp Trp Leu Ala Asp Thr Ser Asp Ile Asn 
             340                345                350
Ile Leu Leu Thr Glu Ile Pro Thr Leu Val Tyr His Lys Asn Ile Pro 
         355                360                365
Glu Trp Asp His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg 
     370                375                380
Leu Tyr Asn Glu Val Val Ser Leu Met Lys Lys Tyr Gln 
 385                390                395



<210> 7839
<211> 2481
<212> DNA
<213> Homo sapiens
<308> U08464
<400> 7839

ggcacgaga  cggcccggc  ggacagctc  agaatgaaa  tgcggttct  ggggttggt  60
gtctgtttg  ttctctgga  cctgcattc  gaggggtct  gagggaaac  gacagctgt  120
gatcctgaa  caaacatga  tgtgagtga  attatctct  actggggat  ccctagtga  180
gaataccta  ttgagacag  agatggata  attctgtgc  ttaaccgaa  tcctcatgg  240
aggaagaac  attctgaca  aggtcccaa  ccagttgtc  tcctgcaac  tggcttgct  300
gcagattct  gtaactggg  cacaaacct  gccaacagc  gcctgggct  cattcttgc  360
gatgctggt  ttgacgtgt  gatgggcaa  agcagagga  atacctggt  tcggaaaca  420
aagacactc  cagtttctc  ggatgaatt  tgggctttc  gttatgatg  gatggcaaa  480
tatgaccta  cagcttcca  taacttcat  ctgaataaa  ctggccaag  acaagtgta  540
tatgtgggt  attctcaag  caccactat  ggttttata  cattttcac  gatccctga  600
ctggctaaa  ggattaaaa  gttttttgc  ctgggtcct  tggcttccg  cgccttctg  660
actagccct  tggccaaat  aggacgatt  ccagatcat  tcattaagg  cttatttgg  720
gacaaagaa  ttcttcccc  gagtgcgtt  ttgaagtgg  tgggtaccc  cgtttgcac  780
catgtcata  tgaaggagc  ctgtggaaa  ctctgtttt  ttctgtgtg  atttaatga  840
agaaattta  atatgtcta  agtggatgt  tatacaaca  attctcctg  tggaacttc  900
gtgcaaaac  tgttacact  gagccaggc  gttaaattc  aaaagtttc  agcctttga  960
tggggaagc  gtgccaaga  ttattttca  tacaaccag  gttatcctc  cacatacaa  1020
gtgaaggac  tgcttgtgc  gactgcagt  tggagcggg  gtcacgact  gcttgcaga  1080
gtctacgac  tcaatatct  actgactca  atcaccaac  tggtgttcc  tgagagcat  1140
ccggaatgg  agcatcttg  cttcatttg  ggcctggat  ccccttgga  gctttataa  1200
aaaattatt  atctaatga  gaaatatca  tgaaagctg  acttgagct  tgtaccacc  1260
agtcaatga  tatgtcatg  gaaaatgtg  ttgcttcat  tctgtaaaa  acttgtttt  1320
ctttcccag  tcttttgtt  ttttatatc  aagaaaatg  taactttga  gatgcccag  1380
tcactctag  ttcaattag  aacatacta  ctatttttt  tttaattag  gctggaata  1440
gaagccagt  tctcaacca  agtattgtc  ctttaagtc  tttaaatat  actgatgtg  1500
aaaaaggtc  ttatatcca  tctgttttt  aaatttaaa  tatattgac  ttttgccct  1560
cataggaca  agtaatata  gtgttggaa  tttaaaatt  tgttgtcat  ggtaaatct  1620
tcactgact  aagcgaggt  taaaagtac  cagttttca  gtccttgcc  taaagagct  1680
tctagtcta  cggtcttgt  gttagagat  taaatgaca  tttatcatg  tttcctgca  1740
caggtgcat  gtcaaatcc  gaaatatca  agctgtgcc  gtaataagg  tgctaacaa  1800
taattttat  aaacctaac  gtgacagct  tgatttgac  cgttttaat  gctcaggtt  1860
aatgaaata  ttttccggc  tcttcaaaa  caaattgca  tgataaaac  aaaacaaaa  1920
tatgtttta  atgctttga  gactgatac  ctcaaccat  tatattcat  agctctcaa  1980
ttcatggca  gccatagtt  tacttatct  agaagcaaa  ccctgtgga  actatacca  2040
tattttttc  gagattaat  tactcttgg  gcccgctac  gtcgttatt  atcacatct  2100
tgtgaagcc  aagccccgt  gttgcccat  agaagtgtc  ttgttcatt  tcacccaaa  2160
gaagtgtga  cgtgatgtt  tcggatgca  actcagctc  gggattcat  ttgtgtctt  2220
gttttatat  catccttat  tttaataca  ctgcttcac  tccctatgt  gggaagtcc  2280
tatttgtct  cttttcttg  agcatcatt  ccttacaat  ctgtccggt  gacaaaatg  2340
caattgata  gtttttctg  tataattac  ttagctgca  taacagtac  atgcttgtt  2400
atggttaat  taggcaggg  gaatactac  ttgtaactt  taaagtctt  aacttttca  2460
taaaattga  tgagactta  a  2481



<210> 7840
<211> 399
<212> PRT
<213> Homo sapiens
<308> P38571
<400> 7840

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Pro 
  1               5                  10                  15
Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
             20                  25                  30
Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
         35                  40                  45
Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
     50                  55                  60
Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
 65                  70                  75                  80
Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
                 85                  90                  95
Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
             100                105                110
Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
         115                120                125
His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
     130                135                140
Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
 145                150                155                160
Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                 165                170                175
Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
             180                185                190
Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
         195                200                205
Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
     210                215                220
Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
 225                230                235                240
Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
                 245                250                255
Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
             260                265                270
Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
         275                280                285
Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
     290                295                300
Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
 305                310                315                320
Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
                 325                330                335
Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
             340                345                350
Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
         355                360                365
Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
     370                375                380
Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
 385                390                395



<210> 7841
<211> 3144
<212> DNA
<213> Rattus norvegicus
<308> S81497
<400> 7841

ccgtgactg  agaagccat  gccaagggt  tcgcaggat  gttgctgtc  caggtgctg  60
agactgagg  tgaaggact  ccccggaga  ggctgcagt  gttcggttc  tgtctcttc  120
gtgtaggat  tgatttctc  taaacttgg  ttaagactt  taaagaagg  cctaattta  180
cgaggcctg  ttgtgaagt  aaattcggc  ggctactct  aacggaaga  agatgcaac  240
gctaggccg  gtgatctgt  tcgtcgttg  gatcctgct  tctgggggc  caacgggga  300
catatcagc  gtggaccct  aagcaaaca  gaatgtgac  gagataatc  tgcactggg  360
atatccaga  cactcagta  agacaggag  tggctacat  ctgggtgtt  accgaatcc  420
gcatgggcg  aagaaccag  ttgataaag  tcccaaacc  gttgtgtat  ttcagtggc  480
acatggctt  ctggcagat  ctagtaact  ggtcacaaa  attgacaac  acagcctgg  540
cttcatcct  gcagatgct  gctttgatg  gtggatggg  aacagcaga  gaaacacct  600
gtctcggaa  cacaagact  tgtcagttt  tcaggatga  tactgggcc  tcagttttg  660
tgagatggc  aaatatgac  tccctgctt  aattaacta  attttgaat  aaactggcc  720
agaacagct  tataatgtg  gccactctc  aggctgcac  ataggtttt  tagcatttt  780
acagatgcc  gaactggca  agaaggtta  aatgttttt  gccctggct  ctgtgttgt  840
tctcaattt  gcttcgggc  cgatggtca  attgggacg  ttgccggat  tgcttcttg  900
ggacttgtt  gggcagaag  aatttcttc  tcagagtgc  atggtgaaa  ggctaagca  960
tcacatttg  acgcacgtc  tcatgaagg  gctttgcgc  aacatcttc  ttctgatat  1020
tggcttcaa  gagaagaat  taaacatgt  tagagtgga  gtgtataca  cacactgtc  1080
tgcgggaac  tctgtgcaa  acatggtac  ctggaccca  gttgttaaa  accataagc  1140
tcaagcttt  gactgggga  gcagtgaca  gaattattt  cattacaat  agagttatc  1200
acccttgta  agcataaaa  acatgcaac  acccactgc  ttatggagc  ggggcaagg  1260
ctggctggc  gacaccagt  acatcaata  cttactgac  gaaatcccc  cgttagtgt  1320
ccacaagaa  attcccgag  gggaccatc  ggattttat  tggggtttg  atgccccct  1380
gaggctgta  aatgaagta  tcagtctaa  gaagaaata  cagtgagtg  caagacttg  1440
gatgcttcc  cttcactag  ggaaaaaag  acagatgtt  gcttaattc  tgcaaaata  1500
tgtgttttc  tggtctaga  catttgtat  ttttatgtg  aagaaaacg  tgatgttga  1560
gacatacat  ggtctggtc  gtaagaagc  cgctggctg  cttctgctt  attctgact  1620
acaagccag  gtcacaacc  gtgatgcct  tgaagtttt  agaaagtat  ggtgttacg  1680
gaaagaagc  attgcaacc  cttgtttac  ttttacggt  gttttcggt  tctgcatgc  1740
gtgcatata  atgcctatg  gtgtgccct  tgctggcca  agcctcctt  tgtggaggt  1800
atggctcac  tcagggtat  ttccctcag  cactggtct  tcgacgaac  agtcagtag  1860
ttgctattc  agttagact  gctgaccag  gagcctcca  aatctgtcc  tctctacct  1920
ccctcacca  gtctacgga  ggtgatgtc  cagccagca  tttacactg  ttctaggga  1980
aggaactca  gttctcatg  ttgatagca  gccctttct  caccaaacc  ttgcctcaa  2040
ccctctgtg  tcgaaaagc  gctcaatta  ctttatgtt  ccacccaat  caagtgaac  2100
agcacaaga  atttcaagc  gttgtttgt  agctaaaaa  caatctgcc  gtgacttga  2160
catgctagg  agaaactcc  ggccctgag  ttgacaaac  tgcagtcca  gttctccag  2220
gattgagac  gggaggctg  tgttacatt  agggttcat  tggagagtg  gactttgtc  2280
ctacaaaac  aaagacaaa  gagaagaag  aaaaaaaaa  cctaaagta  tcagttctc  2340
tctgttagc  tcagagggc  tagagagtt  ctgtgttta  ctatccgaa  aacattttc  2400
tgtctttat  cagtagcta  ctagtgaaa  ccagtgtta  cccagcttc  ccaggcgta  2460
acattctct  ttcaatctc  tcagacctc  gtagcaagc  tttagtgaa  atttagatt  2520
ttcaggcca  gccaagaca  aaatgaata  aataaaaga  aaaagagcc  agactcttg  2580
aagcggttt  cactgattt  aaaataaaa  aaaagaatc  tgaagaatg  catgataaa  2640
tgtgttggt  ccgcatgtg  agtcggatc  cttttctgt  gagaacgtt  tgtggaggg  2700
caaaccact  atttgcccc  agtgaatgt  gctgtagtg  cagcgacag  gcctctgat  2760
ctgagaagc  gggctggct  ccggtgaca  gcatcccag  tcctttccc  agagatgaa  2820
aggatgttt  cagacagag  tcggctcag  gaatttcgc  tggagaatc  gtggtttat  2880
tgcacaatg  tttagtgag  ctgctctgc  cctgatatg  ggaagccct  gactgttca  2940
cgggctcgt  ggcgacggc  gccgtcagc  ggacagtgg  taagttttc  gagtagtca  3000
cacagattc  gggatatcg  tttgtgtcg  ctcctaagg  aggcaggac  atatgactt  3060
gtaacattg  aaaggttca  atttaaact  ttcaataaa  ctcagcctc  caggcctga  3120
catcaaaaa  aaaaaaaaa  aaaa  3144



<210> 7842
<211> 397
<212> PRT
<213> Rattus norvegicus
<308> AAB36043
<400> 7842

Met Gln Leu Leu Gly Arg Val Ile Cys Phe Val Val Gly Ile Leu Leu 
  1               5                  10                  15
Ser Gly Gly Pro Thr Gly Thr Ile Ser Ala Val Asp Pro Glu Ala Asn 
             20                  25                  30
Met Asn Val Thr Glu Ile Ile Met His Trp Gly Tyr Pro Glu His Ser 
         35                  40                  45
Val Gln Thr Gly Asp Gly Tyr Ile Leu Gly Val His Arg Ile Pro His 
     50                  55                  60
Gly Arg Lys Asn Gln Phe Asp Lys Gly Pro Lys Pro Val Val Tyr Leu 
 65                  70                  75                  80
Gln Trp Arg His Gly Phe Leu Ala Asp Ser Ser Asn Trp Val Thr Asn 
                 85                  90                  95
Ile Asp Asn Asn Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp 
             100                105                110
Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys 
         115                120                125
Thr Leu Ser Val Ser Gln Asp Glu Tyr Trp Ala Phe Ser Phe Asp Glu 
     130                135                140
Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Tyr Ile Leu Asn Lys 
 145                150                155                160
Thr Gly Gln Glu Gln Leu Tyr Asn Val Gly His Ser Gln Gly Cys Thr 
                 165                170                175
Ile Gly Phe Ile Ala Phe Ser Gln Met Pro Glu Leu Ala Lys Lys Val 
             180                185                190
Lys Met Phe Phe Ala Leu Ala Pro Val Leu Ser Leu Asn Phe Ala Ser 
         195                200                205
Gly Pro Met Val Lys Leu Gly Arg Leu Pro Asp Leu Leu Leu Glu Asp 
     210                215                220
Leu Phe Gly Gln Lys Gln Phe Leu Pro Gln Ser Ala Met Val Lys Trp 
 225                230                235                240
Leu Ser Thr His Ile Cys Thr His Val Ile Met Lys Glu Leu Cys Ala 
                 245                250                255
Asn Ile Phe Phe Leu Ile Cys Gly Phe Asn Glu Lys Asn Leu Asn Met 
             260                265                270
Ser Arg Val Asp Val Tyr Thr Thr His Cys Pro Ala Gly Thr Ser Val 
         275                280                285
Gln Asn Met Val His Trp Thr Gln Val Val Lys Tyr His Lys Leu Gln 
     290                295                300
Ala Phe Asp Trp Gly Ser Ser Asp Lys Asn Tyr Phe His Tyr Asn Gln 
 305                310                315                320
Ser Tyr Pro Pro Leu Tyr Ser Ile Lys Asp Met Gln Leu Pro Thr Ala 
                 325                330                335
Leu Trp Ser Gly Gly Lys Asp Trp Leu Ala Asp Thr Ser Asp Ile Asn 
             340                345                350
Ile Leu Leu Thr Glu Ile Pro Thr Leu Val Tyr His Lys Asn Ile Pro 
         355                360                365
Glu Trp Asp His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg 
     370                375                380
Leu Tyr Asn Glu Val Val Ser Leu Met Lys Lys Tyr Gln 
 385                390                395



<210> 7843
<211> 2481
<212> DNA
<213> Homo sapiens
<308> U08464
<400> 7843

ggcacgaga  cggcccggc  ggacagctc  agaatgaaa  tgcggttct  ggggttggt  60
gtctgtttg  ttctctgga  cctgcattc  gaggggtct  gagggaaac  gacagctgt  120
gatcctgaa  caaacatga  tgtgagtga  attatctct  actggggat  ccctagtga  180
gaataccta  ttgagacag  agatggata  attctgtgc  ttaaccgaa  tcctcatgg  240
aggaagaac  attctgaca  aggtcccaa  ccagttgtc  tcctgcaac  tggcttgct  300
gcagattct  gtaactggg  cacaaacct  gccaacagc  gcctgggct  cattcttgc  360
gatgctggt  ttgacgtgt  gatgggcaa  agcagagga  atacctggt  tcggaaaca  420
aagacactc  cagtttctc  ggatgaatt  tgggctttc  gttatgatg  gatggcaaa  480
tatgaccta  cagcttcca  taacttcat  ctgaataaa  ctggccaag  acaagtgta  540
tatgtgggt  attctcaag  caccactat  ggttttata  cattttcac  gatccctga  600
ctggctaaa  ggattaaaa  gttttttgc  ctgggtcct  tggcttccg  cgccttctg  660
actagccct  tggccaaat  aggacgatt  ccagatcat  tcattaagg  cttatttgg  720
gacaaagaa  ttcttcccc  gagtgcgtt  ttgaagtgg  tgggtaccc  cgtttgcac  780
catgtcata  tgaaggagc  ctgtggaaa  ctctgtttt  ttctgtgtg  atttaatga  840
agaaattta  atatgtcta  agtggatgt  tatacaaca  attctcctg  tggaacttc  900
gtgcaaaac  tgttacact  gagccaggc  gttaaattc  aaaagtttc  agcctttga  960
tggggaagc  gtgccaaga  ttattttca  tacaaccag  gttatcctc  cacatacaa  1020
gtgaaggac  tgcttgtgc  gactgcagt  tggagcggg  gtcacgact  gcttgcaga  1080
gtctacgac  tcaatatct  actgactca  atcaccaac  tggtgttcc  tgagagcat  1140
ccggaatgg  agcatcttg  cttcatttg  ggcctggat  ccccttgga  gctttataa  1200
aaaattatt  atctaatga  gaaatatca  tgaaagctg  acttgagct  tgtaccacc  1260
agtcaatga  tatgtcatg  gaaaatgtg  ttgcttcat  tctgtaaaa  acttgtttt  1320
ctttcccag  tcttttgtt  ttttatatc  aagaaaatg  taactttga  gatgcccag  1380
tcactctag  ttcaattag  aacatacta  ctatttttt  tttaattag  gctggaata  1440
gaagccagt  tctcaacca  agtattgtc  ctttaagtc  tttaaatat  actgatgtg  1500
aaaaaggtc  ttatatcca  tctgttttt  aaatttaaa  tatattgac  ttttgccct  1560
cataggaca  agtaatata  gtgttggaa  tttaaaatt  tgttgtcat  ggtaaatct  1620
tcactgact  aagcgaggt  taaaagtac  cagttttca  gtccttgcc  taaagagct  1680
tctagtcta  cggtcttgt  gttagagat  taaatgaca  tttatcatg  tttcctgca  1740
caggtgcat  gtcaaatcc  gaaatatca  agctgtgcc  gtaataagg  tgctaacaa  1800
taattttat  aaacctaac  gtgacagct  tgatttgac  cgttttaat  gctcaggtt  1860
aatgaaata  ttttccggc  tcttcaaaa  caaattgca  tgataaaac  aaaacaaaa  1920
tatgtttta  atgctttga  gactgatac  ctcaaccat  tatattcat  agctctcaa  1980
ttcatggca  gccatagtt  tacttatct  agaagcaaa  ccctgtgga  actatacca  2040
tattttttc  gagattaat  tactcttgg  gcccgctac  gtcgttatt  atcacatct  2100
tgtgaagcc  aagccccgt  gttgcccat  agaagtgtc  ttgttcatt  tcacccaaa  2160
gaagtgtga  cgtgatgtt  tcggatgca  actcagctc  gggattcat  ttgtgtctt  2220
gttttatat  catccttat  tttaataca  ctgcttcac  tccctatgt  gggaagtcc  2280
tatttgtct  cttttcttg  agcatcatt  ccttacaat  ctgtccggt  gacaaaatg  2340
caattgata  gtttttctg  tataattac  ttagctgca  taacagtac  atgcttgtt  2400
atggttaat  taggcaggg  gaatactac  ttgtaactt  taaagtctt  aacttttca  2460
taaaattga  tgagactta  a  2481



<210> 7844
<211> 399
<212> PRT
<213> Homo sapiens
<308> P38571
<400> 7844

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Pro 
  1               5                  10                  15
Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
             20                  25                  30
Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
         35                  40                  45
Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
     50                  55                  60
Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
 65                  70                  75                  80
Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
                 85                  90                  95
Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
             100                105                110
Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
         115                120                125
His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
     130                135                140
Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
 145                150                155                160
Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                 165                170                175
Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
             180                185                190
Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
         195                200                205
Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
     210                215                220
Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
 225                230                235                240
Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
                 245                250                255
Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
             260                265                270
Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
         275                280                285
Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
     290                295                300
Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
 305                310                315                320
Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
                 325                330                335
Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
             340                345                350
Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
         355                360                365
Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
     370                375                380
Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
 385                390                395



<210> 7845
<211> 3144
<212> DNA
<213> Rattus norvegicus
<308> S81497
<400> 7845

ccgtgactg  agaagccat  gccaagggt  tcgcaggat  gttgctgtc  caggtgctg  60
agactgagg  tgaaggact  ccccggaga  ggctgcagt  gttcggttc  tgtctcttc  120
gtgtaggat  tgatttctc  taaacttgg  ttaagactt  taaagaagg  cctaattta  180
cgaggcctg  ttgtgaagt  aaattcggc  ggctactct  aacggaaga  agatgcaac  240
gctaggccg  gtgatctgt  tcgtcgttg  gatcctgct  tctgggggc  caacgggga  300
catatcagc  gtggaccct  aagcaaaca  gaatgtgac  gagataatc  tgcactggg  360
atatccaga  cactcagta  agacaggag  tggctacat  ctgggtgtt  accgaatcc  420
gcatgggcg  aagaaccag  ttgataaag  tcccaaacc  gttgtgtat  ttcagtggc  480
acatggctt  ctggcagat  ctagtaact  ggtcacaaa  attgacaac  acagcctgg  540
cttcatcct  gcagatgct  gctttgatg  gtggatggg  aacagcaga  gaaacacct  600
gtctcggaa  cacaagact  tgtcagttt  tcaggatga  tactgggcc  tcagttttg  660
tgagatggc  aaatatgac  tccctgctt  aattaacta  attttgaat  aaactggcc  720
agaacagct  tataatgtg  gccactctc  aggctgcac  ataggtttt  tagcatttt  780
acagatgcc  gaactggca  agaaggtta  aatgttttt  gccctggct  ctgtgttgt  840
tctcaattt  gcttcgggc  cgatggtca  attgggacg  ttgccggat  tgcttcttg  900
ggacttgtt  gggcagaag  aatttcttc  tcagagtgc  atggtgaaa  ggctaagca  960
tcacatttg  acgcacgtc  tcatgaagg  gctttgcgc  aacatcttc  ttctgatat  1020
tggcttcaa  gagaagaat  taaacatgt  tagagtgga  gtgtataca  cacactgtc  1080
tgcgggaac  tctgtgcaa  acatggtac  ctggaccca  gttgttaaa  accataagc  1140
tcaagcttt  gactgggga  gcagtgaca  gaattattt  cattacaat  agagttatc  1200
acccttgta  agcataaaa  acatgcaac  acccactgc  ttatggagc  ggggcaagg  1260
ctggctggc  gacaccagt  acatcaata  cttactgac  gaaatcccc  cgttagtgt  1320
ccacaagaa  attcccgag  gggaccatc  ggattttat  tggggtttg  atgccccct  1380
gaggctgta  aatgaagta  tcagtctaa  gaagaaata  cagtgagtg  caagacttg  1440
gatgcttcc  cttcactag  ggaaaaaag  acagatgtt  gcttaattc  tgcaaaata  1500
tgtgttttc  tggtctaga  catttgtat  ttttatgtg  aagaaaacg  tgatgttga  1560
gacatacat  ggtctggtc  gtaagaagc  cgctggctg  cttctgctt  attctgact  1620
acaagccag  gtcacaacc  gtgatgcct  tgaagtttt  agaaagtat  ggtgttacg  1680
gaaagaagc  attgcaacc  cttgtttac  ttttacggt  gttttcggt  tctgcatgc  1740
gtgcatata  atgcctatg  gtgtgccct  tgctggcca  agcctcctt  tgtggaggt  1800
atggctcac  tcagggtat  ttccctcag  cactggtct  tcgacgaac  agtcagtag  1860
ttgctattc  agttagact  gctgaccag  gagcctcca  aatctgtcc  tctctacct  1920
ccctcacca  gtctacgga  ggtgatgtc  cagccagca  tttacactg  ttctaggga  1980
aggaactca  gttctcatg  ttgatagca  gccctttct  caccaaacc  ttgcctcaa  2040
ccctctgtg  tcgaaaagc  gctcaatta  ctttatgtt  ccacccaat  caagtgaac  2100
agcacaaga  atttcaagc  gttgtttgt  agctaaaaa  caatctgcc  gtgacttga  2160
catgctagg  agaaactcc  ggccctgag  ttgacaaac  tgcagtcca  gttctccag  2220
gattgagac  gggaggctg  tgttacatt  agggttcat  tggagagtg  gactttgtc  2280
ctacaaaac  aaagacaaa  gagaagaag  aaaaaaaaa  cctaaagta  tcagttctc  2340
tctgttagc  tcagagggc  tagagagtt  ctgtgttta  ctatccgaa  aacattttc  2400
tgtctttat  cagtagcta  ctagtgaaa  ccagtgtta  cccagcttc  ccaggcgta  2460
acattctct  ttcaatctc  tcagacctc  gtagcaagc  tttagtgaa  atttagatt  2520
ttcaggcca  gccaagaca  aaatgaata  aataaaaga  aaaagagcc  agactcttg  2580
aagcggttt  cactgattt  aaaataaaa  aaaagaatc  tgaagaatg  catgataaa  2640
tgtgttggt  ccgcatgtg  agtcggatc  cttttctgt  gagaacgtt  tgtggaggg  2700
caaaccact  atttgcccc  agtgaatgt  gctgtagtg  cagcgacag  gcctctgat  2760
ctgagaagc  gggctggct  ccggtgaca  gcatcccag  tcctttccc  agagatgaa  2820
aggatgttt  cagacagag  tcggctcag  gaatttcgc  tggagaatc  gtggtttat  2880
tgcacaatg  tttagtgag  ctgctctgc  cctgatatg  ggaagccct  gactgttca  2940
cgggctcgt  ggcgacggc  gccgtcagc  ggacagtgg  taagttttc  gagtagtca  3000
cacagattc  gggatatcg  tttgtgtcg  ctcctaagg  aggcaggac  atatgactt  3060
gtaacattg  aaaggttca  atttaaact  ttcaataaa  ctcagcctc  caggcctga  3120
catcaaaaa  aaaaaaaaa  aaaa  3144



<210> 7846
<211> 397
<212> PRT
<213> Rattus norvegicus
<308> AAB36043
<400> 7846

Met Gln Leu Leu Gly Arg Val Ile Cys Phe Val Val Gly Ile Leu Leu 
  1               5                  10                  15
Ser Gly Gly Pro Thr Gly Thr Ile Ser Ala Val Asp Pro Glu Ala Asn 
             20                  25                  30
Met Asn Val Thr Glu Ile Ile Met His Trp Gly Tyr Pro Glu His Ser 
         35                  40                  45
Val Gln Thr Gly Asp Gly Tyr Ile Leu Gly Val His Arg Ile Pro His 
     50                  55                  60
Gly Arg Lys Asn Gln Phe Asp Lys Gly Pro Lys Pro Val Val Tyr Leu 
 65                  70                  75                  80
Gln Trp Arg His Gly Phe Leu Ala Asp Ser Ser Asn Trp Val Thr Asn 
                 85                  90                  95
Ile Asp Asn Asn Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp 
             100                105                110
Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys 
         115                120                125
Thr Leu Ser Val Ser Gln Asp Glu Tyr Trp Ala Phe Ser Phe Asp Glu 
     130                135                140
Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Tyr Ile Leu Asn Lys 
 145                150                155                160
Thr Gly Gln Glu Gln Leu Tyr Asn Val Gly His Ser Gln Gly Cys Thr 
                 165                170                175
Ile Gly Phe Ile Ala Phe Ser Gln Met Pro Glu Leu Ala Lys Lys Val 
             180                185                190
Lys Met Phe Phe Ala Leu Ala Pro Val Leu Ser Leu Asn Phe Ala Ser 
         195                200                205
Gly Pro Met Val Lys Leu Gly Arg Leu Pro Asp Leu Leu Leu Glu Asp 
     210                215                220
Leu Phe Gly Gln Lys Gln Phe Leu Pro Gln Ser Ala Met Val Lys Trp 
 225                230                235                240
Leu Ser Thr His Ile Cys Thr His Val Ile Met Lys Glu Leu Cys Ala 
                 245                250                255
Asn Ile Phe Phe Leu Ile Cys Gly Phe Asn Glu Lys Asn Leu Asn Met 
             260                265                270
Ser Arg Val Asp Val Tyr Thr Thr His Cys Pro Ala Gly Thr Ser Val 
         275                280                285
Gln Asn Met Val His Trp Thr Gln Val Val Lys Tyr His Lys Leu Gln 
     290                295                300
Ala Phe Asp Trp Gly Ser Ser Asp Lys Asn Tyr Phe His Tyr Asn Gln 
 305                310                315                320
Ser Tyr Pro Pro Leu Tyr Ser Ile Lys Asp Met Gln Leu Pro Thr Ala 
                 325                330                335
Leu Trp Ser Gly Gly Lys Asp Trp Leu Ala Asp Thr Ser Asp Ile Asn 
             340                345                350
Ile Leu Leu Thr Glu Ile Pro Thr Leu Val Tyr His Lys Asn Ile Pro 
         355                360                365
Glu Trp Asp His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg 
     370                375                380
Leu Tyr Asn Glu Val Val Ser Leu Met Lys Lys Tyr Gln 
 385                390                395



<210> 7847
<211> 2481
<212> DNA
<213> Homo sapiens
<308> U08464
<400> 7847

ggcacgaga  cggcccggc  ggacagctc  agaatgaaa  tgcggttct  ggggttggt  60
gtctgtttg  ttctctgga  cctgcattc  gaggggtct  gagggaaac  gacagctgt  120
gatcctgaa  caaacatga  tgtgagtga  attatctct  actggggat  ccctagtga  180
gaataccta  ttgagacag  agatggata  attctgtgc  ttaaccgaa  tcctcatgg  240
aggaagaac  attctgaca  aggtcccaa  ccagttgtc  tcctgcaac  tggcttgct  300
gcagattct  gtaactggg  cacaaacct  gccaacagc  gcctgggct  cattcttgc  360
gatgctggt  ttgacgtgt  gatgggcaa  agcagagga  atacctggt  tcggaaaca  420
aagacactc  cagtttctc  ggatgaatt  tgggctttc  gttatgatg  gatggcaaa  480
tatgaccta  cagcttcca  taacttcat  ctgaataaa  ctggccaag  acaagtgta  540
tatgtgggt  attctcaag  caccactat  ggttttata  cattttcac  gatccctga  600
ctggctaaa  ggattaaaa  gttttttgc  ctgggtcct  tggcttccg  cgccttctg  660
actagccct  tggccaaat  aggacgatt  ccagatcat  tcattaagg  cttatttgg  720
gacaaagaa  ttcttcccc  gagtgcgtt  ttgaagtgg  tgggtaccc  cgtttgcac  780
catgtcata  tgaaggagc  ctgtggaaa  ctctgtttt  ttctgtgtg  atttaatga  840
agaaattta  atatgtcta  agtggatgt  tatacaaca  attctcctg  tggaacttc  900
gtgcaaaac  tgttacact  gagccaggc  gttaaattc  aaaagtttc  agcctttga  960
tggggaagc  gtgccaaga  ttattttca  tacaaccag  gttatcctc  cacatacaa  1020
gtgaaggac  tgcttgtgc  gactgcagt  tggagcggg  gtcacgact  gcttgcaga  1080
gtctacgac  tcaatatct  actgactca  atcaccaac  tggtgttcc  tgagagcat  1140
ccggaatgg  agcatcttg  cttcatttg  ggcctggat  ccccttgga  gctttataa  1200
aaaattatt  atctaatga  gaaatatca  tgaaagctg  acttgagct  tgtaccacc  1260
agtcaatga  tatgtcatg  gaaaatgtg  ttgcttcat  tctgtaaaa  acttgtttt  1320
ctttcccag  tcttttgtt  ttttatatc  aagaaaatg  taactttga  gatgcccag  1380
tcactctag  ttcaattag  aacatacta  ctatttttt  tttaattag  gctggaata  1440
gaagccagt  tctcaacca  agtattgtc  ctttaagtc  tttaaatat  actgatgtg  1500
aaaaaggtc  ttatatcca  tctgttttt  aaatttaaa  tatattgac  ttttgccct  1560
cataggaca  agtaatata  gtgttggaa  tttaaaatt  tgttgtcat  ggtaaatct  1620
tcactgact  aagcgaggt  taaaagtac  cagttttca  gtccttgcc  taaagagct  1680
tctagtcta  cggtcttgt  gttagagat  taaatgaca  tttatcatg  tttcctgca  1740
caggtgcat  gtcaaatcc  gaaatatca  agctgtgcc  gtaataagg  tgctaacaa  1800
taattttat  aaacctaac  gtgacagct  tgatttgac  cgttttaat  gctcaggtt  1860
aatgaaata  ttttccggc  tcttcaaaa  caaattgca  tgataaaac  aaaacaaaa  1920
tatgtttta  atgctttga  gactgatac  ctcaaccat  tatattcat  agctctcaa  1980
ttcatggca  gccatagtt  tacttatct  agaagcaaa  ccctgtgga  actatacca  2040
tattttttc  gagattaat  tactcttgg  gcccgctac  gtcgttatt  atcacatct  2100
tgtgaagcc  aagccccgt  gttgcccat  agaagtgtc  ttgttcatt  tcacccaaa  2160
gaagtgtga  cgtgatgtt  tcggatgca  actcagctc  gggattcat  ttgtgtctt  2220
gttttatat  catccttat  tttaataca  ctgcttcac  tccctatgt  gggaagtcc  2280
tatttgtct  cttttcttg  agcatcatt  ccttacaat  ctgtccggt  gacaaaatg  2340
caattgata  gtttttctg  tataattac  ttagctgca  taacagtac  atgcttgtt  2400
atggttaat  taggcaggg  gaatactac  ttgtaactt  taaagtctt  aacttttca  2460
taaaattga  tgagactta  a  2481



<210> 7848
<211> 399
<212> PRT
<213> Homo sapiens
<308> P38571
<400> 7848

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Pro 
  1               5                  10                  15
Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
             20                  25                  30
Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
         35                  40                  45
Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
     50                  55                  60
Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
 65                  70                  75                  80
Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
                 85                  90                  95
Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
             100                105                110
Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
         115                120                125
His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
     130                135                140
Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
 145                150                155                160
Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                 165                170                175
Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
             180                185                190
Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
         195                200                205
Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
     210                215                220
Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
 225                230                235                240
Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
                 245                250                255
Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
             260                265                270
Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
         275                280                285
Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
     290                295                300
Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
 305                310                315                320
Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
                 325                330                335
Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
             340                345                350
Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
         355                360                365
Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
     370                375                380
Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
 385                390                395



<210> 7849
<211> 3144
<212> DNA
<213> Rattus norvegicus
<308> S81497
<400> 7849

ccgtgactg  agaagccat  gccaagggt  tcgcaggat  gttgctgtc  caggtgctg  60
agactgagg  tgaaggact  ccccggaga  ggctgcagt  gttcggttc  tgtctcttc  120
gtgtaggat  tgatttctc  taaacttgg  ttaagactt  taaagaagg  cctaattta  180
cgaggcctg  ttgtgaagt  aaattcggc  ggctactct  aacggaaga  agatgcaac  240
gctaggccg  gtgatctgt  tcgtcgttg  gatcctgct  tctgggggc  caacgggga  300
catatcagc  gtggaccct  aagcaaaca  gaatgtgac  gagataatc  tgcactggg  360
atatccaga  cactcagta  agacaggag  tggctacat  ctgggtgtt  accgaatcc  420
gcatgggcg  aagaaccag  ttgataaag  tcccaaacc  gttgtgtat  ttcagtggc  480
acatggctt  ctggcagat  ctagtaact  ggtcacaaa  attgacaac  acagcctgg  540
cttcatcct  gcagatgct  gctttgatg  gtggatggg  aacagcaga  gaaacacct  600
gtctcggaa  cacaagact  tgtcagttt  tcaggatga  tactgggcc  tcagttttg  660
tgagatggc  aaatatgac  tccctgctt  aattaacta  attttgaat  aaactggcc  720
agaacagct  tataatgtg  gccactctc  aggctgcac  ataggtttt  tagcatttt  780
acagatgcc  gaactggca  agaaggtta  aatgttttt  gccctggct  ctgtgttgt  840
tctcaattt  gcttcgggc  cgatggtca  attgggacg  ttgccggat  tgcttcttg  900
ggacttgtt  gggcagaag  aatttcttc  tcagagtgc  atggtgaaa  ggctaagca  960
tcacatttg  acgcacgtc  tcatgaagg  gctttgcgc  aacatcttc  ttctgatat  1020
tggcttcaa  gagaagaat  taaacatgt  tagagtgga  gtgtataca  cacactgtc  1080
tgcgggaac  tctgtgcaa  acatggtac  ctggaccca  gttgttaaa  accataagc  1140
tcaagcttt  gactgggga  gcagtgaca  gaattattt  cattacaat  agagttatc  1200
acccttgta  agcataaaa  acatgcaac  acccactgc  ttatggagc  ggggcaagg  1260
ctggctggc  gacaccagt  acatcaata  cttactgac  gaaatcccc  cgttagtgt  1320
ccacaagaa  attcccgag  gggaccatc  ggattttat  tggggtttg  atgccccct  1380
gaggctgta  aatgaagta  tcagtctaa  gaagaaata  cagtgagtg  caagacttg  1440
gatgcttcc  cttcactag  ggaaaaaag  acagatgtt  gcttaattc  tgcaaaata  1500
tgtgttttc  tggtctaga  catttgtat  ttttatgtg  aagaaaacg  tgatgttga  1560
gacatacat  ggtctggtc  gtaagaagc  cgctggctg  cttctgctt  attctgact  1620
acaagccag  gtcacaacc  gtgatgcct  tgaagtttt  agaaagtat  ggtgttacg  1680
gaaagaagc  attgcaacc  cttgtttac  ttttacggt  gttttcggt  tctgcatgc  1740
gtgcatata  atgcctatg  gtgtgccct  tgctggcca  agcctcctt  tgtggaggt  1800
atggctcac  tcagggtat  ttccctcag  cactggtct  tcgacgaac  agtcagtag  1860
ttgctattc  agttagact  gctgaccag  gagcctcca  aatctgtcc  tctctacct  1920
ccctcacca  gtctacgga  ggtgatgtc  cagccagca  tttacactg  ttctaggga  1980
aggaactca  gttctcatg  ttgatagca  gccctttct  caccaaacc  ttgcctcaa  2040
ccctctgtg  tcgaaaagc  gctcaatta  ctttatgtt  ccacccaat  caagtgaac  2100
agcacaaga  atttcaagc  gttgtttgt  agctaaaaa  caatctgcc  gtgacttga  2160
catgctagg  agaaactcc  ggccctgag  ttgacaaac  tgcagtcca  gttctccag  2220
gattgagac  gggaggctg  tgttacatt  agggttcat  tggagagtg  gactttgtc  2280
ctacaaaac  aaagacaaa  gagaagaag  aaaaaaaaa  cctaaagta  tcagttctc  2340
tctgttagc  tcagagggc  tagagagtt  ctgtgttta  ctatccgaa  aacattttc  2400
tgtctttat  cagtagcta  ctagtgaaa  ccagtgtta  cccagcttc  ccaggcgta  2460
acattctct  ttcaatctc  tcagacctc  gtagcaagc  tttagtgaa  atttagatt  2520
ttcaggcca  gccaagaca  aaatgaata  aataaaaga  aaaagagcc  agactcttg  2580
aagcggttt  cactgattt  aaaataaaa  aaaagaatc  tgaagaatg  catgataaa  2640
tgtgttggt  ccgcatgtg  agtcggatc  cttttctgt  gagaacgtt  tgtggaggg  2700
caaaccact  atttgcccc  agtgaatgt  gctgtagtg  cagcgacag  gcctctgat  2760
ctgagaagc  gggctggct  ccggtgaca  gcatcccag  tcctttccc  agagatgaa  2820
aggatgttt  cagacagag  tcggctcag  gaatttcgc  tggagaatc  gtggtttat  2880
tgcacaatg  tttagtgag  ctgctctgc  cctgatatg  ggaagccct  gactgttca  2940
cgggctcgt  ggcgacggc  gccgtcagc  ggacagtgg  taagttttc  gagtagtca  3000
cacagattc  gggatatcg  tttgtgtcg  ctcctaagg  aggcaggac  atatgactt  3060
gtaacattg  aaaggttca  atttaaact  ttcaataaa  ctcagcctc  caggcctga  3120
catcaaaaa  aaaaaaaaa  aaaa  3144



<210> 7850
<211> 397
<212> PRT
<213> Rattus norvegicus
<308> AAB36043
<400> 7850

Met Gln Leu Leu Gly Arg Val Ile Cys Phe Val Val Gly Ile Leu Leu 
  1               5                  10                  15
Ser Gly Gly Pro Thr Gly Thr Ile Ser Ala Val Asp Pro Glu Ala Asn 
             20                  25                  30
Met Asn Val Thr Glu Ile Ile Met His Trp Gly Tyr Pro Glu His Ser 
         35                  40                  45
Val Gln Thr Gly Asp Gly Tyr Ile Leu Gly Val His Arg Ile Pro His 
     50                  55                  60
Gly Arg Lys Asn Gln Phe Asp Lys Gly Pro Lys Pro Val Val Tyr Leu 
 65                  70                  75                  80
Gln Trp Arg His Gly Phe Leu Ala Asp Ser Ser Asn Trp Val Thr Asn 
                 85                  90                  95
Ile Asp Asn Asn Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp 
             100                105                110
Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys 
         115                120                125
Thr Leu Ser Val Ser Gln Asp Glu Tyr Trp Ala Phe Ser Phe Asp Glu 
     130                135                140
Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Tyr Ile Leu Asn Lys 
 145                150                155                160
Thr Gly Gln Glu Gln Leu Tyr Asn Val Gly His Ser Gln Gly Cys Thr 
                 165                170                175
Ile Gly Phe Ile Ala Phe Ser Gln Met Pro Glu Leu Ala Lys Lys Val 
             180                185                190
Lys Met Phe Phe Ala Leu Ala Pro Val Leu Ser Leu Asn Phe Ala Ser 
         195                200                205
Gly Pro Met Val Lys Leu Gly Arg Leu Pro Asp Leu Leu Leu Glu Asp 
     210                215                220
Leu Phe Gly Gln Lys Gln Phe Leu Pro Gln Ser Ala Met Val Lys Trp 
 225                230                235                240
Leu Ser Thr His Ile Cys Thr His Val Ile Met Lys Glu Leu Cys Ala 
                 245                250                255
Asn Ile Phe Phe Leu Ile Cys Gly Phe Asn Glu Lys Asn Leu Asn Met 
             260                265                270
Ser Arg Val Asp Val Tyr Thr Thr His Cys Pro Ala Gly Thr Ser Val 
         275                280                285
Gln Asn Met Val His Trp Thr Gln Val Val Lys Tyr His Lys Leu Gln 
     290                295                300
Ala Phe Asp Trp Gly Ser Ser Asp Lys Asn Tyr Phe His Tyr Asn Gln 
 305                310                315                320
Ser Tyr Pro Pro Leu Tyr Ser Ile Lys Asp Met Gln Leu Pro Thr Ala 
                 325                330                335
Leu Trp Ser Gly Gly Lys Asp Trp Leu Ala Asp Thr Ser Asp Ile Asn 
             340                345                350
Ile Leu Leu Thr Glu Ile Pro Thr Leu Val Tyr His Lys Asn Ile Pro 
         355                360                365
Glu Trp Asp His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg 
     370                375                380
Leu Tyr Asn Glu Val Val Ser Leu Met Lys Lys Tyr Gln 
 385                390                395



<210> 7851
<211> 2481
<212> DNA
<213> Homo sapiens
<308> U08464
<400> 7851

ggcacgaga  cggcccggc  ggacagctc  agaatgaaa  tgcggttct  ggggttggt  60
gtctgtttg  ttctctgga  cctgcattc  gaggggtct  gagggaaac  gacagctgt  120
gatcctgaa  caaacatga  tgtgagtga  attatctct  actggggat  ccctagtga  180
gaataccta  ttgagacag  agatggata  attctgtgc  ttaaccgaa  tcctcatgg  240
aggaagaac  attctgaca  aggtcccaa  ccagttgtc  tcctgcaac  tggcttgct  300
gcagattct  gtaactggg  cacaaacct  gccaacagc  gcctgggct  cattcttgc  360
gatgctggt  ttgacgtgt  gatgggcaa  agcagagga  atacctggt  tcggaaaca  420
aagacactc  cagtttctc  ggatgaatt  tgggctttc  gttatgatg  gatggcaaa  480
tatgaccta  cagcttcca  taacttcat  ctgaataaa  ctggccaag  acaagtgta  540
tatgtgggt  attctcaag  caccactat  ggttttata  cattttcac  gatccctga  600
ctggctaaa  ggattaaaa  gttttttgc  ctgggtcct  tggcttccg  cgccttctg  660
actagccct  tggccaaat  aggacgatt  ccagatcat  tcattaagg  cttatttgg  720
gacaaagaa  ttcttcccc  gagtgcgtt  ttgaagtgg  tgggtaccc  cgtttgcac  780
catgtcata  tgaaggagc  ctgtggaaa  ctctgtttt  ttctgtgtg  atttaatga  840
agaaattta  atatgtcta  agtggatgt  tatacaaca  attctcctg  tggaacttc  900
gtgcaaaac  tgttacact  gagccaggc  gttaaattc  aaaagtttc  agcctttga  960
tggggaagc  gtgccaaga  ttattttca  tacaaccag  gttatcctc  cacatacaa  1020
gtgaaggac  tgcttgtgc  gactgcagt  tggagcggg  gtcacgact  gcttgcaga  1080
gtctacgac  tcaatatct  actgactca  atcaccaac  tggtgttcc  tgagagcat  1140
ccggaatgg  agcatcttg  cttcatttg  ggcctggat  ccccttgga  gctttataa  1200
aaaattatt  atctaatga  gaaatatca  tgaaagctg  acttgagct  tgtaccacc  1260
agtcaatga  tatgtcatg  gaaaatgtg  ttgcttcat  tctgtaaaa  acttgtttt  1320
ctttcccag  tcttttgtt  ttttatatc  aagaaaatg  taactttga  gatgcccag  1380
tcactctag  ttcaattag  aacatacta  ctatttttt  tttaattag  gctggaata  1440
gaagccagt  tctcaacca  agtattgtc  ctttaagtc  tttaaatat  actgatgtg  1500
aaaaaggtc  ttatatcca  tctgttttt  aaatttaaa  tatattgac  ttttgccct  1560
cataggaca  agtaatata  gtgttggaa  tttaaaatt  tgttgtcat  ggtaaatct  1620
tcactgact  aagcgaggt  taaaagtac  cagttttca  gtccttgcc  taaagagct  1680
tctagtcta  cggtcttgt  gttagagat  taaatgaca  tttatcatg  tttcctgca  1740
caggtgcat  gtcaaatcc  gaaatatca  agctgtgcc  gtaataagg  tgctaacaa  1800
taattttat  aaacctaac  gtgacagct  tgatttgac  cgttttaat  gctcaggtt  1860
aatgaaata  ttttccggc  tcttcaaaa  caaattgca  tgataaaac  aaaacaaaa  1920
tatgtttta  atgctttga  gactgatac  ctcaaccat  tatattcat  agctctcaa  1980
ttcatggca  gccatagtt  tacttatct  agaagcaaa  ccctgtgga  actatacca  2040
tattttttc  gagattaat  tactcttgg  gcccgctac  gtcgttatt  atcacatct  2100
tgtgaagcc  aagccccgt  gttgcccat  agaagtgtc  ttgttcatt  tcacccaaa  2160
gaagtgtga  cgtgatgtt  tcggatgca  actcagctc  gggattcat  ttgtgtctt  2220
gttttatat  catccttat  tttaataca  ctgcttcac  tccctatgt  gggaagtcc  2280
tatttgtct  cttttcttg  agcatcatt  ccttacaat  ctgtccggt  gacaaaatg  2340
caattgata  gtttttctg  tataattac  ttagctgca  taacagtac  atgcttgtt  2400
atggttaat  taggcaggg  gaatactac  ttgtaactt  taaagtctt  aacttttca  2460
taaaattga  tgagactta  a  2481



<210> 7852
<211> 399
<212> PRT
<213> Homo sapiens
<308> P38571
<400> 7852

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Pro 
  1               5                  10                  15
Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
             20                  25                  30
Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
         35                  40                  45
Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
     50                  55                  60
Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
 65                  70                  75                  80
Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
                 85                  90                  95
Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
             100                105                110
Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
         115                120                125
His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
     130                135                140
Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
 145                150                155                160
Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                 165                170                175
Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
             180                185                190
Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
         195                200                205
Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
     210                215                220
Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
 225                230                235                240
Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
                 245                250                255
Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
             260                265                270
Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
         275                280                285
Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
     290                295                300
Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
 305                310                315                320
Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
                 325                330                335
Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
             340                345                350
Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
         355                360                365
Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
     370                375                380
Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
 385                390                395



<210> 7853
<211> 3144
<212> DNA
<213> Rattus norvegicus
<308> S81497
<400> 7853

ccgtgactg  agaagccat  gccaagggt  tcgcaggat  gttgctgtc  caggtgctg  60
agactgagg  tgaaggact  ccccggaga  ggctgcagt  gttcggttc  tgtctcttc  120
gtgtaggat  tgatttctc  taaacttgg  ttaagactt  taaagaagg  cctaattta  180
cgaggcctg  ttgtgaagt  aaattcggc  ggctactct  aacggaaga  agatgcaac  240
gctaggccg  gtgatctgt  tcgtcgttg  gatcctgct  tctgggggc  caacgggga  300
catatcagc  gtggaccct  aagcaaaca  gaatgtgac  gagataatc  tgcactggg  360
atatccaga  cactcagta  agacaggag  tggctacat  ctgggtgtt  accgaatcc  420
gcatgggcg  aagaaccag  ttgataaag  tcccaaacc  gttgtgtat  ttcagtggc  480
acatggctt  ctggcagat  ctagtaact  ggtcacaaa  attgacaac  acagcctgg  540
cttcatcct  gcagatgct  gctttgatg  gtggatggg  aacagcaga  gaaacacct  600
gtctcggaa  cacaagact  tgtcagttt  tcaggatga  tactgggcc  tcagttttg  660
tgagatggc  aaatatgac  tccctgctt  aattaacta  attttgaat  aaactggcc  720
agaacagct  tataatgtg  gccactctc  aggctgcac  ataggtttt  tagcatttt  780
acagatgcc  gaactggca  agaaggtta  aatgttttt  gccctggct  ctgtgttgt  840
tctcaattt  gcttcgggc  cgatggtca  attgggacg  ttgccggat  tgcttcttg  900
ggacttgtt  gggcagaag  aatttcttc  tcagagtgc  atggtgaaa  ggctaagca  960
tcacatttg  acgcacgtc  tcatgaagg  gctttgcgc  aacatcttc  ttctgatat  1020
tggcttcaa  gagaagaat  taaacatgt  tagagtgga  gtgtataca  cacactgtc  1080
tgcgggaac  tctgtgcaa  acatggtac  ctggaccca  gttgttaaa  accataagc  1140
tcaagcttt  gactgggga  gcagtgaca  gaattattt  cattacaat  agagttatc  1200
acccttgta  agcataaaa  acatgcaac  acccactgc  ttatggagc  ggggcaagg  1260
ctggctggc  gacaccagt  acatcaata  cttactgac  gaaatcccc  cgttagtgt  1320
ccacaagaa  attcccgag  gggaccatc  ggattttat  tggggtttg  atgccccct  1380
gaggctgta  aatgaagta  tcagtctaa  gaagaaata  cagtgagtg  caagacttg  1440
gatgcttcc  cttcactag  ggaaaaaag  acagatgtt  gcttaattc  tgcaaaata  1500
tgtgttttc  tggtctaga  catttgtat  ttttatgtg  aagaaaacg  tgatgttga  1560
gacatacat  ggtctggtc  gtaagaagc  cgctggctg  cttctgctt  attctgact  1620
acaagccag  gtcacaacc  gtgatgcct  tgaagtttt  agaaagtat  ggtgttacg  1680
gaaagaagc  attgcaacc  cttgtttac  ttttacggt  gttttcggt  tctgcatgc  1740
gtgcatata  atgcctatg  gtgtgccct  tgctggcca  agcctcctt  tgtggaggt  1800
atggctcac  tcagggtat  ttccctcag  cactggtct  tcgacgaac  agtcagtag  1860
ttgctattc  agttagact  gctgaccag  gagcctcca  aatctgtcc  tctctacct  1920
ccctcacca  gtctacgga  ggtgatgtc  cagccagca  tttacactg  ttctaggga  1980
aggaactca  gttctcatg  ttgatagca  gccctttct  caccaaacc  ttgcctcaa  2040
ccctctgtg  tcgaaaagc  gctcaatta  ctttatgtt  ccacccaat  caagtgaac  2100
agcacaaga  atttcaagc  gttgtttgt  agctaaaaa  caatctgcc  gtgacttga  2160
catgctagg  agaaactcc  ggccctgag  ttgacaaac  tgcagtcca  gttctccag  2220
gattgagac  gggaggctg  tgttacatt  agggttcat  tggagagtg  gactttgtc  2280
ctacaaaac  aaagacaaa  gagaagaag  aaaaaaaaa  cctaaagta  tcagttctc  2340
tctgttagc  tcagagggc  tagagagtt  ctgtgttta  ctatccgaa  aacattttc  2400
tgtctttat  cagtagcta  ctagtgaaa  ccagtgtta  cccagcttc  ccaggcgta  2460
acattctct  ttcaatctc  tcagacctc  gtagcaagc  tttagtgaa  atttagatt  2520
ttcaggcca  gccaagaca  aaatgaata  aataaaaga  aaaagagcc  agactcttg  2580
aagcggttt  cactgattt  aaaataaaa  aaaagaatc  tgaagaatg  catgataaa  2640
tgtgttggt  ccgcatgtg  agtcggatc  cttttctgt  gagaacgtt  tgtggaggg  2700
caaaccact  atttgcccc  agtgaatgt  gctgtagtg  cagcgacag  gcctctgat  2760
ctgagaagc  gggctggct  ccggtgaca  gcatcccag  tcctttccc  agagatgaa  2820
aggatgttt  cagacagag  tcggctcag  gaatttcgc  tggagaatc  gtggtttat  2880
tgcacaatg  tttagtgag  ctgctctgc  cctgatatg  ggaagccct  gactgttca  2940
cgggctcgt  ggcgacggc  gccgtcagc  ggacagtgg  taagttttc  gagtagtca  3000
cacagattc  gggatatcg  tttgtgtcg  ctcctaagg  aggcaggac  atatgactt  3060
gtaacattg  aaaggttca  atttaaact  ttcaataaa  ctcagcctc  caggcctga  3120
catcaaaaa  aaaaaaaaa  aaaa  3144



<210> 7854
<211> 397
<212> PRT
<213> Rattus norvegicus
<308> AAB36043
<400> 7854

Met Gln Leu Leu Gly Arg Val Ile Cys Phe Val Val Gly Ile Leu Leu 
  1               5                  10                  15
Ser Gly Gly Pro Thr Gly Thr Ile Ser Ala Val Asp Pro Glu Ala Asn 
             20                  25                  30
Met Asn Val Thr Glu Ile Ile Met His Trp Gly Tyr Pro Glu His Ser 
         35                  40                  45
Val Gln Thr Gly Asp Gly Tyr Ile Leu Gly Val His Arg Ile Pro His 
     50                  55                  60
Gly Arg Lys Asn Gln Phe Asp Lys Gly Pro Lys Pro Val Val Tyr Leu 
 65                  70                  75                  80
Gln Trp Arg His Gly Phe Leu Ala Asp Ser Ser Asn Trp Val Thr Asn 
                 85                  90                  95
Ile Asp Asn Asn Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp 
             100                105                110
Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys 
         115                120                125
Thr Leu Ser Val Ser Gln Asp Glu Tyr Trp Ala Phe Ser Phe Asp Glu 
     130                135                140
Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Tyr Ile Leu Asn Lys 
 145                150                155                160
Thr Gly Gln Glu Gln Leu Tyr Asn Val Gly His Ser Gln Gly Cys Thr 
                 165                170                175
Ile Gly Phe Ile Ala Phe Ser Gln Met Pro Glu Leu Ala Lys Lys Val 
             180                185                190
Lys Met Phe Phe Ala Leu Ala Pro Val Leu Ser Leu Asn Phe Ala Ser 
         195                200                205
Gly Pro Met Val Lys Leu Gly Arg Leu Pro Asp Leu Leu Leu Glu Asp 
     210                215                220
Leu Phe Gly Gln Lys Gln Phe Leu Pro Gln Ser Ala Met Val Lys Trp 
 225                230                235                240
Leu Ser Thr His Ile Cys Thr His Val Ile Met Lys Glu Leu Cys Ala 
                 245                250                255
Asn Ile Phe Phe Leu Ile Cys Gly Phe Asn Glu Lys Asn Leu Asn Met 
             260                265                270
Ser Arg Val Asp Val Tyr Thr Thr His Cys Pro Ala Gly Thr Ser Val 
         275                280                285
Gln Asn Met Val His Trp Thr Gln Val Val Lys Tyr His Lys Leu Gln 
     290                295                300
Ala Phe Asp Trp Gly Ser Ser Asp Lys Asn Tyr Phe His Tyr Asn Gln 
 305                310                315                320
Ser Tyr Pro Pro Leu Tyr Ser Ile Lys Asp Met Gln Leu Pro Thr Ala 
                 325                330                335
Leu Trp Ser Gly Gly Lys Asp Trp Leu Ala Asp Thr Ser Asp Ile Asn 
             340                345                350
Ile Leu Leu Thr Glu Ile Pro Thr Leu Val Tyr His Lys Asn Ile Pro 
         355                360                365
Glu Trp Asp His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg 
     370                375                380
Leu Tyr Asn Glu Val Val Ser Leu Met Lys Lys Tyr Gln 
 385                390                395



<210> 7855
<211> 2481
<212> DNA
<213> Homo sapiens
<308> U08464
<400> 7855

ggcacgaga  cggcccggc  ggacagctc  agaatgaaa  tgcggttct  ggggttggt  60
gtctgtttg  ttctctgga  cctgcattc  gaggggtct  gagggaaac  gacagctgt  120
gatcctgaa  caaacatga  tgtgagtga  attatctct  actggggat  ccctagtga  180
gaataccta  ttgagacag  agatggata  attctgtgc  ttaaccgaa  tcctcatgg  240
aggaagaac  attctgaca  aggtcccaa  ccagttgtc  tcctgcaac  tggcttgct  300
gcagattct  gtaactggg  cacaaacct  gccaacagc  gcctgggct  cattcttgc  360
gatgctggt  ttgacgtgt  gatgggcaa  agcagagga  atacctggt  tcggaaaca  420
aagacactc  cagtttctc  ggatgaatt  tgggctttc  gttatgatg  gatggcaaa  480
tatgaccta  cagcttcca  taacttcat  ctgaataaa  ctggccaag  acaagtgta  540
tatgtgggt  attctcaag  caccactat  ggttttata  cattttcac  gatccctga  600
ctggctaaa  ggattaaaa  gttttttgc  ctgggtcct  tggcttccg  cgccttctg  660
actagccct  tggccaaat  aggacgatt  ccagatcat  tcattaagg  cttatttgg  720
gacaaagaa  ttcttcccc  gagtgcgtt  ttgaagtgg  tgggtaccc  cgtttgcac  780
catgtcata  tgaaggagc  ctgtggaaa  ctctgtttt  ttctgtgtg  atttaatga  840
agaaattta  atatgtcta  agtggatgt  tatacaaca  attctcctg  tggaacttc  900
gtgcaaaac  tgttacact  gagccaggc  gttaaattc  aaaagtttc  agcctttga  960
tggggaagc  gtgccaaga  ttattttca  tacaaccag  gttatcctc  cacatacaa  1020
gtgaaggac  tgcttgtgc  gactgcagt  tggagcggg  gtcacgact  gcttgcaga  1080
gtctacgac  tcaatatct  actgactca  atcaccaac  tggtgttcc  tgagagcat  1140
ccggaatgg  agcatcttg  cttcatttg  ggcctggat  ccccttgga  gctttataa  1200
aaaattatt  atctaatga  gaaatatca  tgaaagctg  acttgagct  tgtaccacc  1260
agtcaatga  tatgtcatg  gaaaatgtg  ttgcttcat  tctgtaaaa  acttgtttt  1320
ctttcccag  tcttttgtt  ttttatatc  aagaaaatg  taactttga  gatgcccag  1380
tcactctag  ttcaattag  aacatacta  ctatttttt  tttaattag  gctggaata  1440
gaagccagt  tctcaacca  agtattgtc  ctttaagtc  tttaaatat  actgatgtg  1500
aaaaaggtc  ttatatcca  tctgttttt  aaatttaaa  tatattgac  ttttgccct  1560
cataggaca  agtaatata  gtgttggaa  tttaaaatt  tgttgtcat  ggtaaatct  1620
tcactgact  aagcgaggt  taaaagtac  cagttttca  gtccttgcc  taaagagct  1680
tctagtcta  cggtcttgt  gttagagat  taaatgaca  tttatcatg  tttcctgca  1740
caggtgcat  gtcaaatcc  gaaatatca  agctgtgcc  gtaataagg  tgctaacaa  1800
taattttat  aaacctaac  gtgacagct  tgatttgac  cgttttaat  gctcaggtt  1860
aatgaaata  ttttccggc  tcttcaaaa  caaattgca  tgataaaac  aaaacaaaa  1920
tatgtttta  atgctttga  gactgatac  ctcaaccat  tatattcat  agctctcaa  1980
ttcatggca  gccatagtt  tacttatct  agaagcaaa  ccctgtgga  actatacca  2040
tattttttc  gagattaat  tactcttgg  gcccgctac  gtcgttatt  atcacatct  2100
tgtgaagcc  aagccccgt  gttgcccat  agaagtgtc  ttgttcatt  tcacccaaa  2160
gaagtgtga  cgtgatgtt  tcggatgca  actcagctc  gggattcat  ttgtgtctt  2220
gttttatat  catccttat  tttaataca  ctgcttcac  tccctatgt  gggaagtcc  2280
tatttgtct  cttttcttg  agcatcatt  ccttacaat  ctgtccggt  gacaaaatg  2340
caattgata  gtttttctg  tataattac  ttagctgca  taacagtac  atgcttgtt  2400
atggttaat  taggcaggg  gaatactac  ttgtaactt  taaagtctt  aacttttca  2460
taaaattga  tgagactta  a  2481



<210> 7856
<211> 399
<212> PRT
<213> Homo sapiens
<308> P38571
<400> 7856

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Pro 
  1               5                  10                  15
Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
             20                  25                  30
Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
         35                  40                  45
Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
     50                  55                  60
Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
 65                  70                  75                  80
Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
                 85                  90                  95
Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
             100                105                110
Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
         115                120                125
His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
     130                135                140
Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
 145                150                155                160
Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                 165                170                175
Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
             180                185                190
Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
         195                200                205
Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
     210                215                220
Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
 225                230                235                240
Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
                 245                250                255
Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
             260                265                270
Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
         275                280                285
Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
     290                295                300
Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
 305                310                315                320
Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
                 325                330                335
Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
             340                345                350
Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
         355                360                365
Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
     370                375                380
Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
 385                390                395



<210> 7857
<211> 3144
<212> DNA
<213> Rattus norvegicus
<308> S81497
<400> 7857

ccgtgactg  agaagccat  gccaagggt  tcgcaggat  gttgctgtc  caggtgctg  60
agactgagg  tgaaggact  ccccggaga  ggctgcagt  gttcggttc  tgtctcttc  120
gtgtaggat  tgatttctc  taaacttgg  ttaagactt  taaagaagg  cctaattta  180
cgaggcctg  ttgtgaagt  aaattcggc  ggctactct  aacggaaga  agatgcaac  240
gctaggccg  gtgatctgt  tcgtcgttg  gatcctgct  tctgggggc  caacgggga  300
catatcagc  gtggaccct  aagcaaaca  gaatgtgac  gagataatc  tgcactggg  360
atatccaga  cactcagta  agacaggag  tggctacat  ctgggtgtt  accgaatcc  420
gcatgggcg  aagaaccag  ttgataaag  tcccaaacc  gttgtgtat  ttcagtggc  480
acatggctt  ctggcagat  ctagtaact  ggtcacaaa  attgacaac  acagcctgg  540
cttcatcct  gcagatgct  gctttgatg  gtggatggg  aacagcaga  gaaacacct  600
gtctcggaa  cacaagact  tgtcagttt  tcaggatga  tactgggcc  tcagttttg  660
tgagatggc  aaatatgac  tccctgctt  aattaacta  attttgaat  aaactggcc  720
agaacagct  tataatgtg  gccactctc  aggctgcac  ataggtttt  tagcatttt  780
acagatgcc  gaactggca  agaaggtta  aatgttttt  gccctggct  ctgtgttgt  840
tctcaattt  gcttcgggc  cgatggtca  attgggacg  ttgccggat  tgcttcttg  900
ggacttgtt  gggcagaag  aatttcttc  tcagagtgc  atggtgaaa  ggctaagca  960
tcacatttg  acgcacgtc  tcatgaagg  gctttgcgc  aacatcttc  ttctgatat  1020
tggcttcaa  gagaagaat  taaacatgt  tagagtgga  gtgtataca  cacactgtc  1080
tgcgggaac  tctgtgcaa  acatggtac  ctggaccca  gttgttaaa  accataagc  1140
tcaagcttt  gactgggga  gcagtgaca  gaattattt  cattacaat  agagttatc  1200
acccttgta  agcataaaa  acatgcaac  acccactgc  ttatggagc  ggggcaagg  1260
ctggctggc  gacaccagt  acatcaata  cttactgac  gaaatcccc  cgttagtgt  1320
ccacaagaa  attcccgag  gggaccatc  ggattttat  tggggtttg  atgccccct  1380
gaggctgta  aatgaagta  tcagtctaa  gaagaaata  cagtgagtg  caagacttg  1440
gatgcttcc  cttcactag  ggaaaaaag  acagatgtt  gcttaattc  tgcaaaata  1500
tgtgttttc  tggtctaga  catttgtat  ttttatgtg  aagaaaacg  tgatgttga  1560
gacatacat  ggtctggtc  gtaagaagc  cgctggctg  cttctgctt  attctgact  1620
acaagccag  gtcacaacc  gtgatgcct  tgaagtttt  agaaagtat  ggtgttacg  1680
gaaagaagc  attgcaacc  cttgtttac  ttttacggt  gttttcggt  tctgcatgc  1740
gtgcatata  atgcctatg  gtgtgccct  tgctggcca  agcctcctt  tgtggaggt  1800
atggctcac  tcagggtat  ttccctcag  cactggtct  tcgacgaac  agtcagtag  1860
ttgctattc  agttagact  gctgaccag  gagcctcca  aatctgtcc  tctctacct  1920
ccctcacca  gtctacgga  ggtgatgtc  cagccagca  tttacactg  ttctaggga  1980
aggaactca  gttctcatg  ttgatagca  gccctttct  caccaaacc  ttgcctcaa  2040
ccctctgtg  tcgaaaagc  gctcaatta  ctttatgtt  ccacccaat  caagtgaac  2100
agcacaaga  atttcaagc  gttgtttgt  agctaaaaa  caatctgcc  gtgacttga  2160
catgctagg  agaaactcc  ggccctgag  ttgacaaac  tgcagtcca  gttctccag  2220
gattgagac  gggaggctg  tgttacatt  agggttcat  tggagagtg  gactttgtc  2280
ctacaaaac  aaagacaaa  gagaagaag  aaaaaaaaa  cctaaagta  tcagttctc  2340
tctgttagc  tcagagggc  tagagagtt  ctgtgttta  ctatccgaa  aacattttc  2400
tgtctttat  cagtagcta  ctagtgaaa  ccagtgtta  cccagcttc  ccaggcgta  2460
acattctct  ttcaatctc  tcagacctc  gtagcaagc  tttagtgaa  atttagatt  2520
ttcaggcca  gccaagaca  aaatgaata  aataaaaga  aaaagagcc  agactcttg  2580
aagcggttt  cactgattt  aaaataaaa  aaaagaatc  tgaagaatg  catgataaa  2640
tgtgttggt  ccgcatgtg  agtcggatc  cttttctgt  gagaacgtt  tgtggaggg  2700
caaaccact  atttgcccc  agtgaatgt  gctgtagtg  cagcgacag  gcctctgat  2760
ctgagaagc  gggctggct  ccggtgaca  gcatcccag  tcctttccc  agagatgaa  2820
aggatgttt  cagacagag  tcggctcag  gaatttcgc  tggagaatc  gtggtttat  2880
tgcacaatg  tttagtgag  ctgctctgc  cctgatatg  ggaagccct  gactgttca  2940
cgggctcgt  ggcgacggc  gccgtcagc  ggacagtgg  taagttttc  gagtagtca  3000
cacagattc  gggatatcg  tttgtgtcg  ctcctaagg  aggcaggac  atatgactt  3060
gtaacattg  aaaggttca  atttaaact  ttcaataaa  ctcagcctc  caggcctga  3120
catcaaaaa  aaaaaaaaa  aaaa  3144



<210> 7858
<211> 397
<212> PRT
<213> Rattus norvegicus
<308> AAB36043
<400> 7858

Met Gln Leu Leu Gly Arg Val Ile Cys Phe Val Val Gly Ile Leu Leu 
  1               5                  10                  15
Ser Gly Gly Pro Thr Gly Thr Ile Ser Ala Val Asp Pro Glu Ala Asn 
             20                  25                  30
Met Asn Val Thr Glu Ile Ile Met His Trp Gly Tyr Pro Glu His Ser 
         35                  40                  45
Val Gln Thr Gly Asp Gly Tyr Ile Leu Gly Val His Arg Ile Pro His 
     50                  55                  60
Gly Arg Lys Asn Gln Phe Asp Lys Gly Pro Lys Pro Val Val Tyr Leu 
 65                  70                  75                  80
Gln Trp Arg His Gly Phe Leu Ala Asp Ser Ser Asn Trp Val Thr Asn 
                 85                  90                  95
Ile Asp Asn Asn Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp 
             100                105                110
Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys 
         115                120                125
Thr Leu Ser Val Ser Gln Asp Glu Tyr Trp Ala Phe Ser Phe Asp Glu 
     130                135                140
Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Tyr Ile Leu Asn Lys 
 145                150                155                160
Thr Gly Gln Glu Gln Leu Tyr Asn Val Gly His Ser Gln Gly Cys Thr 
                 165                170                175
Ile Gly Phe Ile Ala Phe Ser Gln Met Pro Glu Leu Ala Lys Lys Val 
             180                185                190
Lys Met Phe Phe Ala Leu Ala Pro Val Leu Ser Leu Asn Phe Ala Ser 
         195                200                205
Gly Pro Met Val Lys Leu Gly Arg Leu Pro Asp Leu Leu Leu Glu Asp 
     210                215                220
Leu Phe Gly Gln Lys Gln Phe Leu Pro Gln Ser Ala Met Val Lys Trp 
 225                230                235                240
Leu Ser Thr His Ile Cys Thr His Val Ile Met Lys Glu Leu Cys Ala 
                 245                250                255
Asn Ile Phe Phe Leu Ile Cys Gly Phe Asn Glu Lys Asn Leu Asn Met 
             260                265                270
Ser Arg Val Asp Val Tyr Thr Thr His Cys Pro Ala Gly Thr Ser Val 
         275                280                285
Gln Asn Met Val His Trp Thr Gln Val Val Lys Tyr His Lys Leu Gln 
     290                295                300
Ala Phe Asp Trp Gly Ser Ser Asp Lys Asn Tyr Phe His Tyr Asn Gln 
 305                310                315                320
Ser Tyr Pro Pro Leu Tyr Ser Ile Lys Asp Met Gln Leu Pro Thr Ala 
                 325                330                335
Leu Trp Ser Gly Gly Lys Asp Trp Leu Ala Asp Thr Ser Asp Ile Asn 
             340                345                350
Ile Leu Leu Thr Glu Ile Pro Thr Leu Val Tyr His Lys Asn Ile Pro 
         355                360                365
Glu Trp Asp His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg 
     370                375                380
Leu Tyr Asn Glu Val Val Ser Leu Met Lys Lys Tyr Gln 
 385                390                395



<210> 7859
<211> 2481
<212> DNA
<213> Homo sapiens
<308> U08464
<400> 7859

ggcacgaga  cggcccggc  ggacagctc  agaatgaaa  tgcggttct  ggggttggt  60
gtctgtttg  ttctctgga  cctgcattc  gaggggtct  gagggaaac  gacagctgt  120
gatcctgaa  caaacatga  tgtgagtga  attatctct  actggggat  ccctagtga  180
gaataccta  ttgagacag  agatggata  attctgtgc  ttaaccgaa  tcctcatgg  240
aggaagaac  attctgaca  aggtcccaa  ccagttgtc  tcctgcaac  tggcttgct  300
gcagattct  gtaactggg  cacaaacct  gccaacagc  gcctgggct  cattcttgc  360
gatgctggt  ttgacgtgt  gatgggcaa  agcagagga  atacctggt  tcggaaaca  420
aagacactc  cagtttctc  ggatgaatt  tgggctttc  gttatgatg  gatggcaaa  480
tatgaccta  cagcttcca  taacttcat  ctgaataaa  ctggccaag  acaagtgta  540
tatgtgggt  attctcaag  caccactat  ggttttata  cattttcac  gatccctga  600
ctggctaaa  ggattaaaa  gttttttgc  ctgggtcct  tggcttccg  cgccttctg  660
actagccct  tggccaaat  aggacgatt  ccagatcat  tcattaagg  cttatttgg  720
gacaaagaa  ttcttcccc  gagtgcgtt  ttgaagtgg  tgggtaccc  cgtttgcac  780
catgtcata  tgaaggagc  ctgtggaaa  ctctgtttt  ttctgtgtg  atttaatga  840
agaaattta  atatgtcta  agtggatgt  tatacaaca  attctcctg  tggaacttc  900
gtgcaaaac  tgttacact  gagccaggc  gttaaattc  aaaagtttc  agcctttga  960
tggggaagc  gtgccaaga  ttattttca  tacaaccag  gttatcctc  cacatacaa  1020
gtgaaggac  tgcttgtgc  gactgcagt  tggagcggg  gtcacgact  gcttgcaga  1080
gtctacgac  tcaatatct  actgactca  atcaccaac  tggtgttcc  tgagagcat  1140
ccggaatgg  agcatcttg  cttcatttg  ggcctggat  ccccttgga  gctttataa  1200
aaaattatt  atctaatga  gaaatatca  tgaaagctg  acttgagct  tgtaccacc  1260
agtcaatga  tatgtcatg  gaaaatgtg  ttgcttcat  tctgtaaaa  acttgtttt  1320
ctttcccag  tcttttgtt  ttttatatc  aagaaaatg  taactttga  gatgcccag  1380
tcactctag  ttcaattag  aacatacta  ctatttttt  tttaattag  gctggaata  1440
gaagccagt  tctcaacca  agtattgtc  ctttaagtc  tttaaatat  actgatgtg  1500
aaaaaggtc  ttatatcca  tctgttttt  aaatttaaa  tatattgac  ttttgccct  1560
cataggaca  agtaatata  gtgttggaa  tttaaaatt  tgttgtcat  ggtaaatct  1620
tcactgact  aagcgaggt  taaaagtac  cagttttca  gtccttgcc  taaagagct  1680
tctagtcta  cggtcttgt  gttagagat  taaatgaca  tttatcatg  tttcctgca  1740
caggtgcat  gtcaaatcc  gaaatatca  agctgtgcc  gtaataagg  tgctaacaa  1800
taattttat  aaacctaac  gtgacagct  tgatttgac  cgttttaat  gctcaggtt  1860
aatgaaata  ttttccggc  tcttcaaaa  caaattgca  tgataaaac  aaaacaaaa  1920
tatgtttta  atgctttga  gactgatac  ctcaaccat  tatattcat  agctctcaa  1980
ttcatggca  gccatagtt  tacttatct  agaagcaaa  ccctgtgga  actatacca  2040
tattttttc  gagattaat  tactcttgg  gcccgctac  gtcgttatt  atcacatct  2100
tgtgaagcc  aagccccgt  gttgcccat  agaagtgtc  ttgttcatt  tcacccaaa  2160
gaagtgtga  cgtgatgtt  tcggatgca  actcagctc  gggattcat  ttgtgtctt  2220
gttttatat  catccttat  tttaataca  ctgcttcac  tccctatgt  gggaagtcc  2280
tatttgtct  cttttcttg  agcatcatt  ccttacaat  ctgtccggt  gacaaaatg  2340
caattgata  gtttttctg  tataattac  ttagctgca  taacagtac  atgcttgtt  2400
atggttaat  taggcaggg  gaatactac  ttgtaactt  taaagtctt  aacttttca  2460
taaaattga  tgagactta  a  2481



<210> 7860
<211> 399
<212> PRT
<213> Homo sapiens
<308> P38571
<400> 7860

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Pro 
  1               5                  10                  15
Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
             20                  25                  30
Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
         35                  40                  45
Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
     50                  55                  60
Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
 65                  70                  75                  80
Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
                 85                  90                  95
Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
             100                105                110
Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
         115                120                125
His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
     130                135                140
Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
 145                150                155                160
Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                 165                170                175
Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
             180                185                190
Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
         195                200                205
Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
     210                215                220
Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
 225                230                235                240
Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
                 245                250                255
Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
             260                265                270
Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
         275                280                285
Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
     290                295                300
Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
 305                310                315                320
Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
                 325                330                335
Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
             340                345                350
Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
         355                360                365
Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
     370                375                380
Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
 385                390                395



<210> 7861
<211> 1375
<212> DNA
<213> Rattus norvegicus
<308> S82911
<400> 7861

ctttttttt  ttttctttc  gatttaagc  tagcgtgtt  gtttgtttg  tttggtttt  60
aaacttttt  tggtgtgga  tatctctct  gaccacgcc  gacttggct  cagcgaacg  120
accgaagct  ggagaaagt  acttgagct  aaagttctg  acttcagaa  ggggtttct  180
tctctctct  tctctctct  tctctctct  tctctcctc  actcccccc  ctttcttcc  240
cactcggct  ctctccccc  tcacgccca  agcgtttgg  gttgattcg  gcgttaaga  300
gggggtggg  gggattgga  ggaagacca  gacctccag  tacgggcac  ttctggagc  360
gcaaccggc  ctgggcggc  gcttggata  ccctggcaa  ctcgacacc  tgcaggcga  420
aaagaactt  tccgtcagt  acctgctag  cctggagga  gccggggac  tggtggcgg  480
acaggcgga  gaaagcgtg  gcgaggcgg  ccggagcct  ctggagtca  cgggactga  540
cagtggcag  gacacccct  agcaggaca  tgatcagct  aactctgag  agaagaaga  600
gagaaagca  cggagaaac  ggacaacct  caatagcag  cagctgcag  ccttggagc  660
tgtcttcga  aggacccat  acccggatg  ttttgtacg  gaagatctt  cacgtcggg  720
gaacctcac  gaggccaga  tgcaggtgt  gtttcagaa  cgaagagcc  agttccgca  780
gaatgagcg  gccatgctg  ccaataaaa  cgcttctct  ctcaagtcc  actcaggag  840
cgtgactgc  gtggaacaa  ccattgtac  tcgtcctgc  cccagaccc  ccgattatc  900
ctcctgggg  acagcctct  cgtacagcg  catggctac  tattctgcc  catgtgcca  960
caatagccc  gcgcagggt  tcaacatgg  caacagcat  gccaacctg  gactgaagg  1020
caaggaata  agtttacag  ggaaccagg  gccaacagt  aactgagga  aaaaataat  1080
aaacaggcc  aagaagaaa  caaaaacca  aagacacct  tcctgttct  tcatttctt  1140
atccgctgg  aaaaaaaga  aaaagcaaa  aaacaaagc  agaactaaa  tattgggac  1200
atggcggag  aaagcagga  aggaacaaa  tgaaaatta  ttaacaaat  tttcttctt  1260
ctcttggat  ccatcacca  ttgttgtgt  tgtattttt  ttccttcta  ccatgcttt  1320
ctaagtata  ttcaggctt  ttctattag  ctcaaccca  ccattccta  aattg  1375



<210> 7862
<211> 245
<212> PRT
<213> Rattus norvegicus
<308> AAB46839
<400> 7862

Met Thr Ser Ser Tyr Gly His Val Leu Glu Arg Gln Pro Ala Leu Gly 
  1               5                  10                  15
Gly Arg Leu Asp Ser Pro Gly Asn Leu Asp Thr Leu Gln Ala Lys Lys 
             20                  25                  30
Asn Phe Ser Val Ser His Leu Leu Asp Leu Glu Glu Ala Gly Asp Met 
         35                  40                  45
Val Ala Ala Gln Ala Asp Glu Ser Val Gly Glu Ala Gly Arg Ser Leu 
     50                  55                  60
Leu Glu Ser Pro Gly Leu Thr Ser Gly Ser Asp Thr Pro Gln Gln Asp 
 65                  70                  75                  80
Asn Asp Gln Leu Asn Ser Glu Glu Lys Lys Lys Arg Lys Gln Arg Arg 
                 85                  90                  95
Asn Arg Thr Thr Phe Asn Ser Ser Gln Leu Gln Ala Leu Glu Arg Val 
             100                105                110
Phe Glu Arg Thr His Tyr Pro Asp Ala Phe Val Arg Glu Asp Leu Ala 
         115                120                125
Arg Arg Val Asn Leu Thr Glu Ala Arg Val Gln Val Trp Phe Gln Asn 
     130                135                140
Arg Arg Ala Lys Phe Arg Arg Asn Glu Arg Ala Met Leu Ala Asn Lys 
 145                150                155                160
Asn Ala Ser Leu Leu Lys Ser Tyr Ser Gly Asp Val Thr Ala Val Glu 
                 165                170                175
Gln Pro Ile Val Pro Arg Pro Ala Pro Arg Pro Thr Asp Tyr Leu Ser 
             180                185                190
Trp Gly Thr Ala Ser Pro Tyr Ser Ala Met Ala Thr Tyr Ser Ala Thr 
         195                200                205
Cys Ala Asn Asn Ser Pro Ala Gln Gly Ile Asn Met Ala Asn Ser Ile 
     210                215                220
Ala Asn Leu Arg Leu Lys Ala Lys Glu Tyr Ser Leu Gln Arg Asn Gln 
 225                230                235                240
Val Pro Thr Val Asn 
                 245



<210> 7863
<211> 3428
<212> DNA
<213> Homo sapiens
<308> NM_022716
<400> 7863

ggaaaggag  aagaaggag  ttgtgatgg  gaaaggggg  ctgtgaaac  tcaggcaca  60
cacaaaggc  ttgccacgt  attacaggc  cctattaag  cgagatctg  cctcccagg  120
gtctccaat  ttcttgtat  ccctacaaa  cctcctctg  atgccagtt  gtgcctttt  180
aagtgccag  gagcttctt  atccaactg  gaaggaaaa  ggagcccag  aagaagagg  240
ggagagaga  aaggggaaa  gggggaacc  accagcacc  tccgtcgga  tcttgaagc  300
ttttttttt  aattcttaa  ttttttttt  actctttac  aaaagtaaa  tgagaatcc  360
gctctctaa  acatctgca  gacatcacc  tctcctcct  aaactttag  cactcctga  420
aatccacag  agtgcagag  ggggggaac  cgttttctt  aagatgttt  aaagctgga  480
caagccttc  tctgttggt  cttgaactc  tgcctggga  taacttttt  aacctttaa  540
aaaaccatt  actttgatt  ttctctccc  ccccttctt  tctcttctt  tgtttgcct  600
actcccccg  cctgctggc  tccgctttc  tctctcccc  ttgttatta  ttttagtct  660
tgcgtgtgg  cacttttgg  gagttggaa  ggatttttt  ctcctgact  gaacatagg  720
tgacttttt  atattgtat  ttactgtgg  ttatctctt  ggaccgcgc  ggacttggc  780
tcaggaaat  aaccaatgc  gcggaaggc  gctggtgca  aacgctctg  tctacagaa  840
ggggtcccc  accctcttt  ccaattttt  ttttttggc  ttcctctcc  tccctccct  900
ttcctccct  tctctctct  tctctccac  acccccctc  ttcttcccc  ctcggctcc  960
ctcccccct  gcgcccaca  cgtttggtg  tgattcgag  gggaagagg  gggtgggtg  1020
gatcggtgg  ggagaccat  acctccagc  acgggcacg  tctggagcg  caaccggcg  1080
tgggcggcc  cttggacag  ccgggcaac  tcgacaccc  gcaggcgaa  aagaacttc  1140
ccgtcagtc  cctgctaga  ctggaggaa  ccggggaca  ggtggcggc  caggcggat  1200
agaacgtgg  cgaggctgg  cggagcctg  tggagtcgc  gggactcac  agcggcagc  1260
acaccccgc  gcaggacaa  gaccagctg  actcagaag  aaaaaagaa  agaaagcag  1320
gaaggaata  gacaacctt  aatagcagc  agctgcagg  tttggagcg  gtctttgag  1380
ggacacact  tcctgatgc  tttgtgcga  aagaccttg  ccgccgggt  aacctcacc  1440
aggcgagag  gcaggtgtg  tttcagaac  gaagagcca  gttccgcag  aatgagaga  1500
ccatgctag  caataaaaa  gcttccctc  tcaaatcct  ctcaggaga  gtgactgct  1560
tggagcagc  catcgtacc  cgtcctgct  cgagaccca  cgattatct  tcctggggg  1620
cagcgtctc  gtacagcgc  atggctact  attctgcca  atgtgccaa  aatagccct  1680
cacagggca  caacatggc  aacagcatt  ccaacctga  actgaaggc  aaggaatat  1740
gtttacaga  gaaccaggt  ccaacagtc  actgaggaa  aaaaataat  aaacaggcc  1800
aagaagaaa  caaaaacca  aagacacct  tcctgctct  ttatttctt  atctgctgg  1860
gggaaaaag  aaattacaa  caaacaaac  aagcagaac  aaaatattg  gaccatggc  1920
gagaaaagc  ggagaggag  aaaatgaaa  ttagttaac  aatgttcct  ctccctctg  1980
gataccacc  ccacttgtt  ctgtgtgtg  ttattttgt  tttctttca  tcatgcttt  2040
cttaatgta  tccaggctt  ttcagatag  ttcagccca  ccaccccca  gattgtatg  2100
agttttaaa  aaaactaca  cagccaaag  aactatata  atatatata  atatatata  2160
ccagaatga  tgcctctac  gtcctcatt  acttgtttg  accttagtg  cttaccctg  2220
cctcttccc  gttctcttt  tagaagctc  aggagcttt  gaaaagcca  agtctttct  2280
aagaatctg  gctggacag  cataattcc  tttctcatt  tctccatct  tgttggtca  2340
ggtaaggtt  ttccatcag  ctctgaaaa  atagttgtg  acaacatct  ctcactgga  2400
tgtctgatc  aatgtaatt  gctgcgtct  gctaattct  agcactaaa  tctacatct  2460
agctataga  ttaagcttg  agctacaga  tatatcact  tcaccacca  ccctcaccc  2520
atgcaatca  tcaatcaat  atcttaagt  aaagatatt  gttgtcttt  aatgatttg  2580
tgtcacaga  tatttggta  aagaaatat  tttcacctg  gagaggaag  gaaatttct  2640
tagtaacac  aagagtgag  tctaaaagg  atgcccaca  ctctttcgt  ccttaagga  2700
agtgagatg  acacttata  atatactgt  tatatttat  tatttatat  tatatttca  2760
atatatata  aatattgca  gcttaagtt  gcaatttcc  aaacaatac  aaaagcaaa  2820
tacacaccc  caccactgt  cttatctct  tagtgatga  acattaatt  gggatcttg  2880
tgcttttct  tttctacac  aagttttca  taaagccac  gaataattg  tagggcagc  2940
gtttgagaa  aggtcccat  ttcacatta  ggctttaaa  gaattagaa  ctatttgag  3000
ctataaaaa  gtccttgag  ttggagcct  agctctggt  aaatgctga  acatctgat  3060
tatcatggg  attgcagtt  gagagagta  ggaatacca  ttagtcatc  atccgttct  3120
cacttagca  gaatatgaa  gaaaggcac  tgtttaaga  gaataccta  aggtttttc  3180
aaattccaa  atttaaaag  caattgtgg  ctattttta  tttttaata  tttgaaata  3240
agtttagtg  ctagggctg  gagccagga  tgatcttcc  tttcttttt  tttgttccc  3300
gccatgctt  tgtaacttg  caggtggac  tgaccaact  cattaccat  ctgtgcctc  3360
gtttaccca  ttgtaaaat  ggattaata  tacttacct  cctcacagg  gtgttgtga  3420
gctctatt  3428



<210> 7864
<211> 245
<212> PRT
<213> Homo sapiens
<308> P54821
<400> 7864

Met Thr Ser Ser Tyr Gly His Val Leu Glu Arg Gln Pro Ala Leu Gly 
  1               5                  10                  15
Gly Arg Leu Asp Ser Pro Gly Asn Leu Asp Thr Leu Gln Ala Lys Lys 
             20                  25                  30
Asn Phe Ser Val Ser His Leu Leu Asp Leu Glu Glu Ala Gly Asp Met 
         35                  40                  45
Val Ala Ala Gln Ala Asp Glu Asn Val Gly Glu Ala Gly Arg Ser Leu 
     50                  55                  60
Leu Glu Ser Pro Gly Leu Thr Ser Gly Ser Asp Thr Pro Gln Gln Asp 
 65                  70                  75                  80
Asn Asp Gln Leu Asn Ser Glu Glu Lys Lys Lys Arg Lys Gln Arg Arg 
                 85                  90                  95
Asn Arg Thr Thr Phe Asn Ser Ser Gln Leu Gln Ala Leu Glu Arg Val 
             100                105                110
Phe Glu Arg Thr His Tyr Pro Asp Ala Phe Val Arg Glu Asp Leu Ala 
         115                120                125
Arg Arg Val Asn Leu Thr Glu Ala Arg Val Gln Val Trp Phe Gln Asn 
     130                135                140
Arg Arg Ala Lys Phe Arg Arg Asn Glu Arg Ala Met Leu Ala Asn Lys 
 145                150                155                160
Asn Ala Ser Leu Leu Lys Ser Tyr Ser Gly Asp Val Thr Ala Val Glu 
                 165                170                175
Gln Pro Ile Val Pro Arg Pro Ala Pro Arg Pro Thr Asp Tyr Leu Ser 
             180                185                190
Trp Gly Thr Ala Ser Pro Tyr Ser Ala Met Ala Thr Tyr Ser Ala Thr 
         195                200                205
Cys Ala Asn Asn Ser Pro Ala Gln Gly Ile Asn Met Ala Asn Ser Ile 
     210                215                220
Ala Asn Leu Arg Leu Lys Ala Lys Glu Tyr Ser Leu Gln Arg Asn Gln 
 225                230                235                240
Val Pro Thr Val Asn 
                 245



<210> 7865
<211> 3429
<212> DNA
<213> Rattus norvegicus
<308> S83194
<400> 7865

aagcgggca  ggcggggcg  gcccagcgg  agcgagccc  gcgcccacc  cagagactg  60
cgcctggtg  ctaggttcc  aacaggaat  tccacggac  gaagtgatg  agcgcagtc  120
agccgtctg  tgccaagac  ctcgagcgg  actggtaga  cgggtggca  ccatcagtg  180
ggcccacct  gaagaggca  aggagggcc  agagcctgc  agcaatggt  tggaccccc  240
accccgggc  agagctgcc  ctgtgatcc  tggcagtgc  tcaagaccc  caccagtgc  300
tcccagcct  tctgctaga  agttctccc  gcaggaaag  ccagcggga  gctgtctag  360
ggctcaggt  gggccttac  ctacaggac  tgccagtca  atgtctcct  gggcttggc  420
gagacccac  atcgagtcc  accatgtgg  catctcaga  acagaggac  gtgtgcaac  480
gaaccagta  aagctgcag  gtgagattg  caagggtgc  tatggtgtg  tgaggctgg  540
ctacaatga  agggaagac  gacactatg  aatgaaagt  ctttccaaa  agaagttac  600
gaagcagta  ggctttcct  gccgtcctc  cccgagagg  tcccaagct  ctcagggag  660
gccagccaa  cagctgctg  ccctggagc  tgtatacca  gagattgcc  ttttaaaga  720
actggacca  gtgaatgta  tcaagttga  cgaggtcct  gatgatcct  ctgaagaca  780
tctctattt  gtgtttgac  tcctgagaa  gggaccagt  atggaagtg  cctgcgaca  840
gcccttccc  gaggagcaa  ctcgcctct  cctccggga  atcatcctg  gcctcgagt  900
cttgcactg  cagaagatt  tgcacaggg  catcaagcc  tccaatctg  tccttgggg  960
cgatgggca  gtgaagatc  ccgactttg  tgtcagcaa  cagtttgag  ggaatgatg  1020
tcagctgtc  agtacggca  ggaccccag  attcatggc  ccggaggcc  tttctgaca  1080
cggccagag  ttcagtggg  aggccttgg  tgtatgggc  actggggtt  cactgtatt  1140
ttttgtcta  gggaagtgc  cattcattg  tgagtacat  ctggccctg  acagaaaga  1200
caagaatga  gccgtggtg  tccctgagg  gccggaggt  agcgaggaa  tcaaagacc  1260
gatcctgaa  atgctagac  agaatcctg  aacaagaat  ggggtgtct  atatcaagt  1320
acacccttg  gtgaccaag  atggagagg  gcccctccc  tcagaggag  aacactgca  1380
tgtggtaga  gtgactgag  aggaggtga  gaactcagt  aagctcatc  ccagctgga  1440
cactgtgat  ctggtcaag  ctatgctga  aaagcgttc  tttggaaac  catttgagc  1500
ccaagcacg  agggaagaa  gatctatgt  tgcgccagg  aacttactg  tgaaagaag  1560
atgtggaga  gggggcaaa  gcccagagc  tcccggagt  caggaagat  aggctgcat  1620
ctgagtccc  gcatgtgcc  agggccatc  gcagcatgc  cattccgct  ctccagagg  1680
ccaccgccc  catgcaatc  tcgcccctg  aggcagggg  ctggggact  cagcccctc  1740
cctggcccc  ctcacccat  gtgctgcat  acctgcgca  aggcatatc  agggacagg  1800
ttggaatgt  tatcatttg  ggctcgggg  tcccggttg  ttctctctg  tctgatcta  1860
cttgtgggg  atattagaa  ccctacctg  ctggctggt  aggcccagg  cagaaggca  1920
gagaccaaa  tagcaggtg  agacctggt  ggctgcttc  cagagaact  ccatagtga  1980
cggtggcct  cccagctgc  gcacacgag  agtgattgt  tcacttctg  gtggaaggt  2040
ctgagtgct  gagtcctca  atctctagt  tggatgcta  aagtaatga  gcgtgcctg  2100
gagaagact  atcttggag  atccagatt  ctctcattg  cttttacct  agggcttgg  2160
tgggagcgg  tgttatgga  agcatcttc  ggctttggg  agtccgtgg  acactgtac  2220
gcagtcacg  ggatctgac  ttcatagac  gtgttttac  cttggcact  gctggagaa  2280
ggaccaaag  gaatccagc  tagagcata  acctgagcc  ggagcagtg  acttctcct  2340
ccaacctcc  ttcctctct  acggatctc  agaatgaag  ttacagaac  ccaggagtg  2400
caaggaggg  cacggactc  cagcactgt  gccctgcag  tgtggaagt  actgggatc  2460
aggcgctga  ccgacactg  cttactcac  acatgctct  atggaggag  ctcagccag  2520
tgagggacc  tacaagacg  actcctgtc  ggctggtgg  ccttctgtc  gttgcttca  2580
tacaggaca  cagacagtc  gcccacaca  gtcagagct  cacagttgg  acacacgtg  2640
acactgccc  ttcagaaca  atgtcagct  tctggattc  gtggtcgtc  ggctattct  2700
atgtttact  ataatgctc  tagggattg  tccccaaag  gagatgagc  ggactcagg  2760
agccctctc  gaaagcctc  cataagaga  cctggctgc  cacatgggt  tcaagaatg  2820
aggagggct  ggctagaaa  gagagaggc  gtgcgggag  gctggttcc  actcttatc  2880
ctgtgccca  gggtgtaca  tgctccttc  tgtgcacat  cgtgtgtgt  cccatctgc  2940
gtatacagc  cacttgcat  tctcatact  gcacatgca  ctgtaatat  gtttctatg  3000
caacttatg  ctaggagca  aaggtagcc  attgtcaaa  ggctcccat  tcaacccaa  3060
tcctctgca  taaggcagc  agtgtaacc  agggcttga  aacaaataa  ctaatccta  3120
ctctaagaa  acttttata  agtgaatag  aggcaagtt  tgccaacca  taaatagca  3180
agagtcagg  agcttcacc  atgggaccc  cacaggaaa  gctcggagt  gggtggctg  3240
ctcattgtc  ccagcagag  caggaaggc  tgctcactg  cacctgttg  tgagagctt  3300
ggttggctt  ggttttgaa  gtagcacaa  tgaacaaac  ccataagag  gtttataaa  3360
attaacttc  taggaagtg  attaaaaac  ataaaagcc  tttgttgag  taaaaaaaa  3420
aaaaaaaaa  3429



<210> 7866
<211> 505
<212> PRT
<213> Rattus norvegicus
<308> AAB46910
<400> 7866

Met Glu Arg Ser Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
  1               5                  10                  15
Val Glu Arg Val Ala Ala Ile Ser Val Ala His Leu Glu Glu Ala Glu 
             20                  25                  30
Glu Gly Pro Glu Pro Ala Ser Asn Gly Val Asp Pro Pro Pro Arg Ala 
         35                  40                  45
Arg Ala Ala Ser Val Ile Pro Gly Ser Ala Ser Arg Pro Thr Pro Val 
     50                  55                  60
Arg Pro Ser Leu Ser Ala Arg Lys Phe Ser Leu Gln Glu Arg Pro Ala 
 65                  70                  75                  80
Gly Ser Cys Leu Glu Ala Gln Val Gly Pro Tyr Ser Thr Gly Pro Ala 
                 85                  90                  95
Ser His Met Ser Pro Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His 
             100                105                110
His Val Ala Ile Ser Asp Thr Glu Asp Cys Val Gln Leu Asn Gln Tyr 
         115                120                125
Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
     130                135                140
Ala Tyr Asn Glu Arg Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
 145                150                155                160
Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                 165                170                175
Arg Gly Ser Gln Ala Pro Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
             180                185                190
Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
         195                200                205
Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
     210                215                220
Asn Leu Tyr Leu Val Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu 
 225                230                235                240
Val Pro Cys Asp Lys Pro Phe Pro Glu Glu Gln Ala Arg Leu Tyr Leu 
                 245                250                255
Arg Asp Ile Ile Leu Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val 
             260                265                270
His Arg Asp Ile Lys Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His 
         275                280                285
Val Lys Ile Ala Asp Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp 
     290                295                300
Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu 
 305                310                315                320
Ala Ile Ser Asp Thr Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val 
                 325                330                335
Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro 
             340                345                350
Phe Ile Asp Glu Tyr Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu 
         355                360                365
Ala Val Val Phe Pro Glu Glu Pro Glu Val Ser Glu Glu Leu Lys Asp 
     370                375                380
Leu Ile Leu Lys Met Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val 
 385                390                395                400
Ser Asp Ile Lys Leu His Pro Trp Val Thr Lys His Gly Glu Glu Pro 
                 405                410                415
Leu Pro Ser Glu Glu Glu His Cys Ser Val Val Glu Val Thr Glu Glu 
             420                425                430
Glu Val Lys Asn Ser Val Lys Leu Ile Pro Ser Trp Thr Thr Val Ile 
         435                440                445
Leu Val Lys Ser Met Leu Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu 
     450                455                460
Pro Gln Ala Arg Arg Glu Glu Arg Ser Met Ser Ala Pro Gly Asn Leu 
 465                470                475                480
Leu Leu Lys Glu Gly Cys Gly Glu Gly Gly Lys Ser Pro Glu Leu Pro 
                 485                490                495
Gly Val Gln Glu Asp Glu Ala Ala Ser 
             500                505



<210> 7867
<211> 3583
<212> DNA
<213> Homo sapiens
<308> NM_032294
<400> 7867

ctgggcccc  gcgaggcgg  ggggcgggg  ggggcgggg  ggggcgcgc  gcaggagcg  60
gtggggccg  ccgccgggc  gcggacact  tcgcccggc  cccaggttc  caacaaggc  120
acgcagaag  acccccttg  ctgaagcaa  ggagggggg  ccagctgtc  gctgccagg  180
tcctcgggc  gagctggta  aacgggtgg  agccatcga  gtgactcac  tggaggagg  240
agatggtgg  ccagagcct  ctagaaacg  tgtggaccc  ccaccacgg  ccagagctg  300
ctctgtgat  cctggcagt  cttcaagac  gctcccagc  cggcctagc  tctcagcca  360
gaagctttc  ctacaggag  ggccagcag  aagctatct  gaggcgcag  ctgggcctt  420
tgccacggg  cctgccagc  acatctccc  ccgggcctg  cggaggccc  ccatcgagt  480
ccaccacgt  gccatctca  atgcagagg  ctgcgtgca  ctgaaccag  acaagctgc  540
gagtgagat  ggcaagggt  cctacggtg  ggtgaggct  gcctacaac  aaagtgaag  600
cagacacta  gcaatgaaa  tcctttcca  aaagaagtt  ctgaagcag  atggctttc  660
acgtcgccc  cccccgaga  ggtcccagg  tgcccaggg  ggaccagcc  agcagctgc  720
gcccctgga  cgggtgtac  aggagattg  catcctgaa  aagctggac  acgtgaatg  780
ggtcaaact  atcgaggtc  tggatgacc  agctgagga  aacctctat  tggtgtttg  840
cctcctgag  aaggggccc  tcatggaag  gccctgtga  aagcccttc  cggaggagc  900
agctcgcct  tacctgcgg  acgtcatcc  gggcctcga  tacttgcac  gccagaaga  960
cgtccacag  gacatcaag  catccaacc  gctcctggg  gatgatggg  acgtgaaga  1020
cgccgactt  ggcgtcagc  accagtttg  ggggaacga  gctcagctg  ccagcacgg  1080
gggaacccc  gcattcatg  cccccgagg  catttctga  tccggccag  gcttcagtg  1140
gaaggcctt  gatgtatgg  ccactggcg  cacgttgta  tgctttgtc  atgggaagt  1200
cccattcat  gacgatttc  tcctggccc  ccacaggaa  atcaagaat  agcccgtgg  1260
gtttcctga  gagccagaa  tcagcgagg  gctcaagga  ctgatcctg  agatgttag  1320
caagaatcc  gagacgaga  ttggggtgc  agacatcaa  ttgcaccct  gggtgacca  1380
gaacgggga  gagcccctt  cttcggagg  ggagcactg  agcgtggtg  aggtgacag  1440
ggaggaggt  aagaactca  tcaggctca  ccccagctg  accacggtg  tcctggtga  1500
gtccatgct  aggaagcgt  cctttggga  cccgtttga  ccccaagca  ggagggaag  1560
gcgatccat  tctgctcca  gaaacctac  ggtgaaaga  gggtttggt  aagggggca  1620
gagcccaga  ctccccggc  tccaggaag  cgaggctgc  tcctgagcc  ctgcatgca  1680
ccagggcca  ccggcagca  actcatccc  cgcctccag  ggcccaccc  tcatgcaac  1740
gccgccccc  caggcaggg  gctggggac  gcagcccca  tcccgcccc  cccccatcg  1800
gctgcatga  ctccacgca  gcacgtcca  ggacagact  gaatgtatg  catttgggg  1860
cttgggggc  gggctccca  gaggccatc  tcctcttct  ggccctcct  ggcctgacc  1920
attctgtgg  gaaaccggg  gcccatgga  cctcagaaa  gccacccgg  tggttggca  1980
ggcctgggg  aggaggcag  ggcaggaga  caagatggc  ggtggaggc  aggcttacc  2040
caacggaag  gacctcccg  tggggccgg  caggcctgg  tcagctgcc  caggcatat  2100
gtggagagg  gggtaccct  cccaccttg  ggtggtggc  ccagagctc  tgtctattc  2160
gacgctggt  tgggggctc  gacccctca  tggggacag  gccagtgtt  gagaattct  2220
attcctttt  tgttgtctt  tacttttgt  tttaacctg  gggttcggg  agaggccct  2280
cttgggaac  tctcacgag  tttcctaca  cttccgtgg  tcccagcac  gcccaagat  2340
atttggcag  caagtggat  gaactaact  tcctggact  tgtttcgca  tcggcgtta  2400
ctggaaagt  gactgaacg  aatcaagct  tgagcagag  cctgaagcg  aagcaccac  2460
tcgtccctg  ccatctcac  ctctccctt  atgatgccc  tagagctga  gctggagaa  2520
acaccaggg  tgactttga  cgagggcca  ggacgcgac  ggcctgtgg  cctgcgcat  2580
ctgaaataa  tggaaccca  cctctcctc  tacaccggc  tacccatct  ggcccaaga  2640
ctgcactca  actcctaca  cgaaggaca  actgtccag  tcggaggga  cacgagaca  2700
agaacctgg  ggggtgtgc  cgctggcag  tggcctctg  ggcaattgc  tcaccctga  2760
gacatcagc  gtcagcctg  tcagagcgg  ggtgctgga  cgcgtgcag  cacagctct  2820
ccggagcag  cttcacctt  tctctggga  cagtgtccg  ctggccgac  tggcatttg  2880
tgaccgaat  ctcatagag  ttgaccccc  cagggtcac  caggactcg  acactgccc  2940
ggaaacatg  atggacaag  gcttttggc  acaggtgtg  gtgtcctgt  ggaggaggg  3000
ttgtttgga  aagggaggc  ggctggggg  gaaacccgg  tcccgctgc  tctccgcgc  3060
tgtgggtgc  tgtcgcgtg  tcatctgtt  cacacagct  actcgtatg  cctgcactg  3120
tacatgcat  tgtaataca  tttctacgt  tatttaagg  taggagccg  atgtgcccc  3180
ttgtcagtg  gtccacgtt  ctccccggc  cctctgggc  aaggcagtg  ggcccgagg  3240
ttaaaaagt  actcggtac  gtttttaag  acactttta  agagttagt  gaaggcaag  3300
taagagcca  tcactgatc  ccaagtgtt  cttgagcat  tggtctggg  ggaccactt  3360
gatcggacc  acccttgga  agctcaggg  taggcccag  tgggatgct  accctgtca  3420
tgagggttt  ggttggcat  gttgttttt  aatgtagca  aagcgatga  caaactcta  3480
aagagtgtt  taaaaatta  cttcccagg  agtgagtta  aaacaataa  agccctttc  3540
tgagttaaa  agaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaa  3583



<210> 7868
<211> 505
<212> PRT
<213> Homo sapiens
<308> NP_115670
<400> 7868

Met Glu Gly Gly Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
  1               5                  10                  15
Val Glu Arg Val Ala Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp 
             20                  25                  30
Gly Gly Pro Glu Pro Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala 
         35                  40                  45
Arg Ala Ala Ser Val Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala 
     50                  55                  60
Arg Pro Ser Leu Ser Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala 
 65                  70                  75                  80
Gly Ser Tyr Leu Glu Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala 
                 85                  90                  95
Ser His Ile Ser Pro Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His 
             100                105                110
His Val Ala Ile Ser Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr 
         115                120                125
Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
     130                135                140
Ala Tyr Asn Glu Ser Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
 145                150                155                160
Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                 165                170                175
Arg Gly Ser Gln Ala Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
             180                185                190
Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
         195                200                205
Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
     210                215                220
Asn Leu Tyr Leu Val Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu 
 225                230                235                240
Val Pro Cys Asp Lys Pro Phe Ser Glu Glu Gln Ala Arg Leu Tyr Leu 
                 245                250                255
Arg Asp Val Ile Leu Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val 
             260                265                270
His Arg Asp Ile Lys Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His 
         275                280                285
Val Lys Ile Ala Asp Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp 
     290                295                300
Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu 
 305                310                315                320
Ala Ile Ser Asp Ser Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val 
                 325                330                335
Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro 
             340                345                350
Phe Ile Asp Asp Phe Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu 
         355                360                365
Pro Val Val Phe Pro Glu Glu Pro Glu Ile Ser Glu Glu Leu Lys Asp 
     370                375                380
Leu Ile Leu Lys Met Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val 
 385                390                395                400
Pro Asp Ile Lys Leu His Pro Trp Val Thr Lys Asn Gly Glu Glu Pro 
                 405                410                415
Leu Pro Ser Glu Glu Glu His Cys Ser Val Val Glu Val Thr Glu Glu 
             420                425                430
Glu Val Lys Asn Ser Val Arg Leu Ile Pro Ser Trp Thr Thr Val Ile 
         435                440                445
Leu Val Lys Ser Met Leu Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu 
     450                455                460
Pro Gln Ala Arg Arg Glu Glu Arg Ser Met Ser Ala Pro Gly Asn Leu 
 465                470                475                480
Leu Val Lys Glu Gly Phe Gly Glu Gly Gly Lys Ser Pro Glu Leu Pro 
                 485                490                495
Gly Val Gln Glu Asp Glu Ala Ala Ser 
             500                505



<210> 7869
<211> 3429
<212> DNA
<213> Rattus norvegicus
<308> S83194
<400> 7869

aagcgggca  ggcggggcg  gcccagcgg  agcgagccc  gcgcccacc  cagagactg  60
cgcctggtg  ctaggttcc  aacaggaat  tccacggac  gaagtgatg  agcgcagtc  120
agccgtctg  tgccaagac  ctcgagcgg  actggtaga  cgggtggca  ccatcagtg  180
ggcccacct  gaagaggca  aggagggcc  agagcctgc  agcaatggt  tggaccccc  240
accccgggc  agagctgcc  ctgtgatcc  tggcagtgc  tcaagaccc  caccagtgc  300
tcccagcct  tctgctaga  agttctccc  gcaggaaag  ccagcggga  gctgtctag  360
ggctcaggt  gggccttac  ctacaggac  tgccagtca  atgtctcct  gggcttggc  420
gagacccac  atcgagtcc  accatgtgg  catctcaga  acagaggac  gtgtgcaac  480
gaaccagta  aagctgcag  gtgagattg  caagggtgc  tatggtgtg  tgaggctgg  540
ctacaatga  agggaagac  gacactatg  aatgaaagt  ctttccaaa  agaagttac  600
gaagcagta  ggctttcct  gccgtcctc  cccgagagg  tcccaagct  ctcagggag  660
gccagccaa  cagctgctg  ccctggagc  tgtatacca  gagattgcc  ttttaaaga  720
actggacca  gtgaatgta  tcaagttga  cgaggtcct  gatgatcct  ctgaagaca  780
tctctattt  gtgtttgac  tcctgagaa  gggaccagt  atggaagtg  cctgcgaca  840
gcccttccc  gaggagcaa  ctcgcctct  cctccggga  atcatcctg  gcctcgagt  900
cttgcactg  cagaagatt  tgcacaggg  catcaagcc  tccaatctg  tccttgggg  960
cgatgggca  gtgaagatc  ccgactttg  tgtcagcaa  cagtttgag  ggaatgatg  1020
tcagctgtc  agtacggca  ggaccccag  attcatggc  ccggaggcc  tttctgaca  1080
cggccagag  ttcagtggg  aggccttgg  tgtatgggc  actggggtt  cactgtatt  1140
ttttgtcta  gggaagtgc  cattcattg  tgagtacat  ctggccctg  acagaaaga  1200
caagaatga  gccgtggtg  tccctgagg  gccggaggt  agcgaggaa  tcaaagacc  1260
gatcctgaa  atgctagac  agaatcctg  aacaagaat  ggggtgtct  atatcaagt  1320
acacccttg  gtgaccaag  atggagagg  gcccctccc  tcagaggag  aacactgca  1380
tgtggtaga  gtgactgag  aggaggtga  gaactcagt  aagctcatc  ccagctgga  1440
cactgtgat  ctggtcaag  ctatgctga  aaagcgttc  tttggaaac  catttgagc  1500
ccaagcacg  agggaagaa  gatctatgt  tgcgccagg  aacttactg  tgaaagaag  1560
atgtggaga  gggggcaaa  gcccagagc  tcccggagt  caggaagat  aggctgcat  1620
ctgagtccc  gcatgtgcc  agggccatc  gcagcatgc  cattccgct  ctccagagg  1680
ccaccgccc  catgcaatc  tcgcccctg  aggcagggg  ctggggact  cagcccctc  1740
cctggcccc  ctcacccat  gtgctgcat  acctgcgca  aggcatatc  agggacagg  1800
ttggaatgt  tatcatttg  ggctcgggg  tcccggttg  ttctctctg  tctgatcta  1860
cttgtgggg  atattagaa  ccctacctg  ctggctggt  aggcccagg  cagaaggca  1920
gagaccaaa  tagcaggtg  agacctggt  ggctgcttc  cagagaact  ccatagtga  1980
cggtggcct  cccagctgc  gcacacgag  agtgattgt  tcacttctg  gtggaaggt  2040
ctgagtgct  gagtcctca  atctctagt  tggatgcta  aagtaatga  gcgtgcctg  2100
gagaagact  atcttggag  atccagatt  ctctcattg  cttttacct  agggcttgg  2160
tgggagcgg  tgttatgga  agcatcttc  ggctttggg  agtccgtgg  acactgtac  2220
gcagtcacg  ggatctgac  ttcatagac  gtgttttac  cttggcact  gctggagaa  2280
ggaccaaag  gaatccagc  tagagcata  acctgagcc  ggagcagtg  acttctcct  2340
ccaacctcc  ttcctctct  acggatctc  agaatgaag  ttacagaac  ccaggagtg  2400
caaggaggg  cacggactc  cagcactgt  gccctgcag  tgtggaagt  actgggatc  2460
aggcgctga  ccgacactg  cttactcac  acatgctct  atggaggag  ctcagccag  2520
tgagggacc  tacaagacg  actcctgtc  ggctggtgg  ccttctgtc  gttgcttca  2580
tacaggaca  cagacagtc  gcccacaca  gtcagagct  cacagttgg  acacacgtg  2640
acactgccc  ttcagaaca  atgtcagct  tctggattc  gtggtcgtc  ggctattct  2700
atgtttact  ataatgctc  tagggattg  tccccaaag  gagatgagc  ggactcagg  2760
agccctctc  gaaagcctc  cataagaga  cctggctgc  cacatgggt  tcaagaatg  2820
aggagggct  ggctagaaa  gagagaggc  gtgcgggag  gctggttcc  actcttatc  2880
ctgtgccca  gggtgtaca  tgctccttc  tgtgcacat  cgtgtgtgt  cccatctgc  2940
gtatacagc  cacttgcat  tctcatact  gcacatgca  ctgtaatat  gtttctatg  3000
caacttatg  ctaggagca  aaggtagcc  attgtcaaa  ggctcccat  tcaacccaa  3060
tcctctgca  taaggcagc  agtgtaacc  agggcttga  aacaaataa  ctaatccta  3120
ctctaagaa  acttttata  agtgaatag  aggcaagtt  tgccaacca  taaatagca  3180
agagtcagg  agcttcacc  atgggaccc  cacaggaaa  gctcggagt  gggtggctg  3240
ctcattgtc  ccagcagag  caggaaggc  tgctcactg  cacctgttg  tgagagctt  3300
ggttggctt  ggttttgaa  gtagcacaa  tgaacaaac  ccataagag  gtttataaa  3360
attaacttc  taggaagtg  attaaaaac  ataaaagcc  tttgttgag  taaaaaaaa  3420
aaaaaaaaa  3429



<210> 7870
<211> 505
<212> PRT
<213> Rattus norvegicus
<308> AAB46910
<400> 7870

Met Glu Arg Ser Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
  1               5                  10                  15
Val Glu Arg Val Ala Ala Ile Ser Val Ala His Leu Glu Glu Ala Glu 
             20                  25                  30
Glu Gly Pro Glu Pro Ala Ser Asn Gly Val Asp Pro Pro Pro Arg Ala 
         35                  40                  45
Arg Ala Ala Ser Val Ile Pro Gly Ser Ala Ser Arg Pro Thr Pro Val 
     50                  55                  60
Arg Pro Ser Leu Ser Ala Arg Lys Phe Ser Leu Gln Glu Arg Pro Ala 
 65                  70                  75                  80
Gly Ser Cys Leu Glu Ala Gln Val Gly Pro Tyr Ser Thr Gly Pro Ala 
                 85                  90                  95
Ser His Met Ser Pro Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His 
             100                105                110
His Val Ala Ile Ser Asp Thr Glu Asp Cys Val Gln Leu Asn Gln Tyr 
         115                120                125
Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
     130                135                140
Ala Tyr Asn Glu Arg Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
 145                150                155                160
Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                 165                170                175
Arg Gly Ser Gln Ala Pro Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
             180                185                190
Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
         195                200                205
Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
     210                215                220
Asn Leu Tyr Leu Val Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu 
 225                230                235                240
Val Pro Cys Asp Lys Pro Phe Pro Glu Glu Gln Ala Arg Leu Tyr Leu 
                 245                250                255
Arg Asp Ile Ile Leu Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val 
             260                265                270
His Arg Asp Ile Lys Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His 
         275                280                285
Val Lys Ile Ala Asp Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp 
     290                295                300
Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu 
 305                310                315                320
Ala Ile Ser Asp Thr Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val 
                 325                330                335
Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro 
             340                345                350
Phe Ile Asp Glu Tyr Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu 
         355                360                365
Ala Val Val Phe Pro Glu Glu Pro Glu Val Ser Glu Glu Leu Lys Asp 
     370                375                380
Leu Ile Leu Lys Met Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val 
 385                390                395                400
Ser Asp Ile Lys Leu His Pro Trp Val Thr Lys His Gly Glu Glu Pro 
                 405                410                415
Leu Pro Ser Glu Glu Glu His Cys Ser Val Val Glu Val Thr Glu Glu 
             420                425                430
Glu Val Lys Asn Ser Val Lys Leu Ile Pro Ser Trp Thr Thr Val Ile 
         435                440                445
Leu Val Lys Ser Met Leu Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu 
     450                455                460
Pro Gln Ala Arg Arg Glu Glu Arg Ser Met Ser Ala Pro Gly Asn Leu 
 465                470                475                480
Leu Leu Lys Glu Gly Cys Gly Glu Gly Gly Lys Ser Pro Glu Leu Pro 
                 485                490                495
Gly Val Gln Glu Asp Glu Ala Ala Ser 
             500                505



<210> 7871
<211> 3583
<212> DNA
<213> Homo sapiens
<308> NM_032294
<400> 7871

ctgggcccc  gcgaggcgg  ggggcgggg  ggggcgggg  ggggcgcgc  gcaggagcg  60
gtggggccg  ccgccgggc  gcggacact  tcgcccggc  cccaggttc  caacaaggc  120
acgcagaag  acccccttg  ctgaagcaa  ggagggggg  ccagctgtc  gctgccagg  180
tcctcgggc  gagctggta  aacgggtgg  agccatcga  gtgactcac  tggaggagg  240
agatggtgg  ccagagcct  ctagaaacg  tgtggaccc  ccaccacgg  ccagagctg  300
ctctgtgat  cctggcagt  cttcaagac  gctcccagc  cggcctagc  tctcagcca  360
gaagctttc  ctacaggag  ggccagcag  aagctatct  gaggcgcag  ctgggcctt  420
tgccacggg  cctgccagc  acatctccc  ccgggcctg  cggaggccc  ccatcgagt  480
ccaccacgt  gccatctca  atgcagagg  ctgcgtgca  ctgaaccag  acaagctgc  540
gagtgagat  ggcaagggt  cctacggtg  ggtgaggct  gcctacaac  aaagtgaag  600
cagacacta  gcaatgaaa  tcctttcca  aaagaagtt  ctgaagcag  atggctttc  660
acgtcgccc  cccccgaga  ggtcccagg  tgcccaggg  ggaccagcc  agcagctgc  720
gcccctgga  cgggtgtac  aggagattg  catcctgaa  aagctggac  acgtgaatg  780
ggtcaaact  atcgaggtc  tggatgacc  agctgagga  aacctctat  tggtgtttg  840
cctcctgag  aaggggccc  tcatggaag  gccctgtga  aagcccttc  cggaggagc  900
agctcgcct  tacctgcgg  acgtcatcc  gggcctcga  tacttgcac  gccagaaga  960
cgtccacag  gacatcaag  catccaacc  gctcctggg  gatgatggg  acgtgaaga  1020
cgccgactt  ggcgtcagc  accagtttg  ggggaacga  gctcagctg  ccagcacgg  1080
gggaacccc  gcattcatg  cccccgagg  catttctga  tccggccag  gcttcagtg  1140
gaaggcctt  gatgtatgg  ccactggcg  cacgttgta  tgctttgtc  atgggaagt  1200
cccattcat  gacgatttc  tcctggccc  ccacaggaa  atcaagaat  agcccgtgg  1260
gtttcctga  gagccagaa  tcagcgagg  gctcaagga  ctgatcctg  agatgttag  1320
caagaatcc  gagacgaga  ttggggtgc  agacatcaa  ttgcaccct  gggtgacca  1380
gaacgggga  gagcccctt  cttcggagg  ggagcactg  agcgtggtg  aggtgacag  1440
ggaggaggt  aagaactca  tcaggctca  ccccagctg  accacggtg  tcctggtga  1500
gtccatgct  aggaagcgt  cctttggga  cccgtttga  ccccaagca  ggagggaag  1560
gcgatccat  tctgctcca  gaaacctac  ggtgaaaga  gggtttggt  aagggggca  1620
gagcccaga  ctccccggc  tccaggaag  cgaggctgc  tcctgagcc  ctgcatgca  1680
ccagggcca  ccggcagca  actcatccc  cgcctccag  ggcccaccc  tcatgcaac  1740
gccgccccc  caggcaggg  gctggggac  gcagcccca  tcccgcccc  cccccatcg  1800
gctgcatga  ctccacgca  gcacgtcca  ggacagact  gaatgtatg  catttgggg  1860
cttgggggc  gggctccca  gaggccatc  tcctcttct  ggccctcct  ggcctgacc  1920
attctgtgg  gaaaccggg  gcccatgga  cctcagaaa  gccacccgg  tggttggca  1980
ggcctgggg  aggaggcag  ggcaggaga  caagatggc  ggtggaggc  aggcttacc  2040
caacggaag  gacctcccg  tggggccgg  caggcctgg  tcagctgcc  caggcatat  2100
gtggagagg  gggtaccct  cccaccttg  ggtggtggc  ccagagctc  tgtctattc  2160
gacgctggt  tgggggctc  gacccctca  tggggacag  gccagtgtt  gagaattct  2220
attcctttt  tgttgtctt  tacttttgt  tttaacctg  gggttcggg  agaggccct  2280
cttgggaac  tctcacgag  tttcctaca  cttccgtgg  tcccagcac  gcccaagat  2340
atttggcag  caagtggat  gaactaact  tcctggact  tgtttcgca  tcggcgtta  2400
ctggaaagt  gactgaacg  aatcaagct  tgagcagag  cctgaagcg  aagcaccac  2460
tcgtccctg  ccatctcac  ctctccctt  atgatgccc  tagagctga  gctggagaa  2520
acaccaggg  tgactttga  cgagggcca  ggacgcgac  ggcctgtgg  cctgcgcat  2580
ctgaaataa  tggaaccca  cctctcctc  tacaccggc  tacccatct  ggcccaaga  2640
ctgcactca  actcctaca  cgaaggaca  actgtccag  tcggaggga  cacgagaca  2700
agaacctgg  ggggtgtgc  cgctggcag  tggcctctg  ggcaattgc  tcaccctga  2760
gacatcagc  gtcagcctg  tcagagcgg  ggtgctgga  cgcgtgcag  cacagctct  2820
ccggagcag  cttcacctt  tctctggga  cagtgtccg  ctggccgac  tggcatttg  2880
tgaccgaat  ctcatagag  ttgaccccc  cagggtcac  caggactcg  acactgccc  2940
ggaaacatg  atggacaag  gcttttggc  acaggtgtg  gtgtcctgt  ggaggaggg  3000
ttgtttgga  aagggaggc  ggctggggg  gaaacccgg  tcccgctgc  tctccgcgc  3060
tgtgggtgc  tgtcgcgtg  tcatctgtt  cacacagct  actcgtatg  cctgcactg  3120
tacatgcat  tgtaataca  tttctacgt  tatttaagg  taggagccg  atgtgcccc  3180
ttgtcagtg  gtccacgtt  ctccccggc  cctctgggc  aaggcagtg  ggcccgagg  3240
ttaaaaagt  actcggtac  gtttttaag  acactttta  agagttagt  gaaggcaag  3300
taagagcca  tcactgatc  ccaagtgtt  cttgagcat  tggtctggg  ggaccactt  3360
gatcggacc  acccttgga  agctcaggg  taggcccag  tgggatgct  accctgtca  3420
tgagggttt  ggttggcat  gttgttttt  aatgtagca  aagcgatga  caaactcta  3480
aagagtgtt  taaaaatta  cttcccagg  agtgagtta  aaacaataa  agccctttc  3540
tgagttaaa  agaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaa  3583



<210> 7872
<211> 505
<212> PRT
<213> Homo sapiens
<308> NP_115670
<400> 7872

Met Glu Gly Gly Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
  1               5                  10                  15
Val Glu Arg Val Ala Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp 
             20                  25                  30
Gly Gly Pro Glu Pro Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala 
         35                  40                  45
Arg Ala Ala Ser Val Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala 
     50                  55                  60
Arg Pro Ser Leu Ser Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala 
 65                  70                  75                  80
Gly Ser Tyr Leu Glu Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala 
                 85                  90                  95
Ser His Ile Ser Pro Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His 
             100                105                110
His Val Ala Ile Ser Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr 
         115                120                125
Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
     130                135                140
Ala Tyr Asn Glu Ser Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
 145                150                155                160
Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                 165                170                175
Arg Gly Ser Gln Ala Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
             180                185                190
Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
         195                200                205
Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
     210                215                220
Asn Leu Tyr Leu Val Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu 
 225                230                235                240
Val Pro Cys Asp Lys Pro Phe Ser Glu Glu Gln Ala Arg Leu Tyr Leu 
                 245                250                255
Arg Asp Val Ile Leu Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val 
             260                265                270
His Arg Asp Ile Lys Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His 
         275                280                285
Val Lys Ile Ala Asp Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp 
     290                295                300
Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu 
 305                310                315                320
Ala Ile Ser Asp Ser Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val 
                 325                330                335
Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro 
             340                345                350
Phe Ile Asp Asp Phe Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu 
         355                360                365
Pro Val Val Phe Pro Glu Glu Pro Glu Ile Ser Glu Glu Leu Lys Asp 
     370                375                380
Leu Ile Leu Lys Met Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val 
 385                390                395                400
Pro Asp Ile Lys Leu His Pro Trp Val Thr Lys Asn Gly Glu Glu Pro 
                 405                410                415
Leu Pro Ser Glu Glu Glu His Cys Ser Val Val Glu Val Thr Glu Glu 
             420                425                430
Glu Val Lys Asn Ser Val Arg Leu Ile Pro Ser Trp Thr Thr Val Ile 
         435                440                445
Leu Val Lys Ser Met Leu Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu 
     450                455                460
Pro Gln Ala Arg Arg Glu Glu Arg Ser Met Ser Ala Pro Gly Asn Leu 
 465                470                475                480
Leu Val Lys Glu Gly Phe Gly Glu Gly Gly Lys Ser Pro Glu Leu Pro 
                 485                490                495
Gly Val Gln Glu Asp Glu Ala Ala Ser 
             500                505



<210> 7873
<211> 2480
<212> DNA
<213> Rattus norvegicus
<308> S83279
<400> 7873

gaattcggc  cgagtagac  catggcttc  cctctgagg  tcgacgggc  tgtggtcct  60
gtcaccggc  ccgggggag  gttgggcag  gcttatgcc  tggcttttg  agaaagagg  120
gcattagtt  ttgtgaatg  cttaggagg  gacttcaaa  gcgttggga  aggctcttc  180
gccgcagac  aggtcgtgg  agaaataag  aggagaggc  ggaaagcgg  ggccaatta  240
gattcagtc  aagcaggcg  gaagcttgt  aagacagca  tggacacat  cggcagaat  300
gatgttgtg  tgaacaatg  tgggatcct  agggaccgt  ccttctcta  gataagtga  360
gaagactgg  atataattc  aagagttca  ttgcggggc  ccttccaag  gacccgggc  420
gcatgggat  atatgaaga  gcagaatta  ggaagaatc  ttatgacgg  ctcagcttc  480
ggaatatac  gcaactttg  ccaggcaaa  tatagtgct  caaagctgg  ccttctggg  540
ctcgccaat  ctctcgtga  tgaaggcag  aagaacaac  ttcattgta  caccattgc  600
ccaaacgct  ggtcacgga  gacagagac  gtgatgcca  aagacctcg  tgaagccct  660
aagccagag  atgtggcac  gctggtcct  tggctttgc  atgagagct  tgaggaaaa  720
ggtggcttg  ttgaggttg  agcaggatg  attggaaaa  tgcgctggg  gaggaccct  780
ggagccatt  tcaggaagc  gaatcagcc  atgactccc  aggcagtga  ggacaactg  840
gtgaagatc  gtgacttca  caatgccag  aagccgaag  gcattcaag  gtccacagg  900
ggtataatc  aagttttac  taaaataga  tcagaagga  tctcacaaa  tcacaccgg  960
caagtggca  ctgcagatg  atcaggatt  gctggcgtc  ttggccaca  acttccttc  1020
ttttcttct  catatacgg  actgcagtg  attatgtat  ccctcggag  aggagcttc  1080
gtcaaaaat  caaaggact  gaagtttgt  tatgaaggg  gtgctgact  ctcctgttt  1140
cctacattt  gagtcattg  cgctcagaa  tccttgatg  gtggaggct  agcagaggt  1200
cctgggctg  caatcaact  tgcaaaggt  cttcatggg  agcagtact  ggagttgta  1260
aagccactt  cccgatcag  ggaattaaa  tgtgaagca  ttattgctg  catcctgga  1320
aaaggctct  gcatagtga  tgttatgga  gtctattct  attctggca  ggaacttat  1380
tgctataat  agttctctg  cttcgttgt  ggctctgga  gctttggtg  aaaacggac  1440
tcagaaaaa  tcaaagcag  tgtagccgt  ccaagtcgg  ctccagatg  tgtactgag  1500
gataccact  cactgaatc  ggccgctct  taccgcctc  gtggagact  gaatccttt  1560
cacattgac  cgagctttg  gagcattgc  ggttttgag  aacccatat  acacggatt  1620
tgtactttt  ggttttctg  aaggcatgt  ttacagcag  ttgcggata  tgatgtgtc  1680
agattcaag  ccattaagg  tcgttttgc  aaaccagtg  atccaggac  aactctaca  1740
actgagatg  ggaaggaag  aaacagaat  cattttcaa  ccaaggtcc  agagactgg  1800
gacattgtc  tttccaatg  atatgtgga  cttgttcct  catctggag  ttccgctca  1860
acaccttct  agggtggag  actgcagag  gctcttgta  ttggggaaa  aggtcgacg  1920
ctcaaggat  ttggacgtg  ggtggtaaa  aaagtaaat  ctgtatttg  atggcatat  1980
acgaaaaat  ggaatgttg  agccaagtg  accattgac  tgaagaacg  ctctggaga  2040
gtttaccaa  gccctgcca  aggctctgc  gacacgacc  tcacaattt  tgatgagga  2100
ttcatggaa  tggtcctgg  caagcttaa  ccacagaat  ccttcttca  tggcagact  2160
aaggcccga  gaaacatca  gctgagcca  aagctacag  tgattctga  agactatgc  2220
aagctctga  ggacccact  cgtgcttta  taaaaccag  atcattacg  tctgtctac  2280
cagtcatgc  ccagccttc  ttgaaacga  ccacggtaa  gtgcagcag  aattgctta  2340
cattttcag  ttcagataa  tttcagatt  tcattttct  ctaattttt  acatattat  2400
tttacaagg  actgtaatc  agctagcaa  taattgttc  gttcataga  ctgtatctt  2460
ataaaaaaa  aaaaaaaaaa  2480



<210> 7874
<211> 735
<212> PRT
<213> Rattus norvegicus
<308> AAB49519
<400> 7874

Met Ala Ser Pro Leu Arg Phe Asp Gly Arg Val Val Leu Val Thr Gly 
  1               5                  10                  15
Ala Gly Gly Gly Leu Gly Arg Ala Tyr Ala Leu Ala Phe Ala Glu Arg 
             20                  25                  30
Gly Ala Leu Val Val Val Asn Asp Leu Gly Gly Asp Phe Lys Gly Val 
         35                  40                  45
Gly Lys Gly Ser Ser Ala Ala Asp Lys Val Val Glu Glu Ile Arg Arg 
     50                  55                  60
Arg Gly Gly Lys Ala Val Ala Asn Tyr Asp Ser Val Glu Ala Gly Glu 
 65                  70                  75                  80
Lys Leu Val Lys Thr Ala Leu Asp Thr Phe Gly Arg Ile Asp Val Val 
                 85                  90                  95
Val Asn Asn Ala Gly Ile Leu Arg Asp Arg Ser Phe Ser Arg Ile Ser 
             100                105                110
Asp Glu Asp Trp Asp Ile Ile Gln Arg Val His Leu Arg Gly Ser Phe 
         115                120                125
Gln Val Thr Arg Ala Ala Trp Asp His Met Lys Lys Gln Asn Tyr Gly 
     130                135                140
Arg Ile Ile Met Thr Ala Ser Ala Ser Gly Ile Tyr Gly Asn Phe Gly 
 145                150                155                160
Gln Ala Asn Tyr Ser Ala Ala Lys Leu Gly Leu Leu Gly Leu Ala Asn 
                 165                170                175
Thr Leu Val Ile Glu Gly Arg Lys Asn Asn Ile His Cys Asn Thr Ile 
             180                185                190
Ala Pro Asn Ala Gly Ser Arg Met Thr Glu Thr Val Met Pro Glu Asp 
         195                200                205
Leu Val Glu Ala Leu Lys Pro Glu Tyr Val Ala Pro Leu Val Leu Trp 
     210                215                220
Leu Cys His Glu Ser Cys Glu Glu Asn Gly Gly Leu Phe Glu Val Gly 
 225                230                235                240
Ala Gly Trp Ile Gly Lys Leu Arg Trp Glu Arg Thr Leu Gly Ala Ile 
                 245                250                255
Val Arg Lys Arg Asn Gln Pro Met Thr Pro Glu Ala Val Arg Asp Asn 
             260                265                270
Trp Val Lys Ile Cys Asp Phe Ser Asn Ala Ser Lys Pro Lys Ser Ile 
         275                280                285
Gln Glu Ser Thr Gly Gly Ile Ile Glu Val Leu His Lys Ile Asp Ser 
     290                295                300
Glu Gly Ile Ser Gln Asn His Thr Gly Gln Val Ala Ser Ala Asp Ala 
 305                310                315                320
Ser Gly Phe Ala Gly Val Val Gly His Lys Leu Pro Ser Phe Ser Ser 
                 325                330                335
Ser Tyr Thr Glu Leu Gln Cys Ile Met Tyr Ala Leu Gly Val Gly Ala 
             340                345                350
Ser Val Lys Asn Pro Lys Asp Leu Lys Phe Val Tyr Glu Gly Ser Ala 
         355                360                365
Asp Phe Ser Cys Leu Pro Thr Phe Gly Val Ile Val Ala Gln Lys Ser 
     370                375                380
Leu Met Ser Gly Gly Leu Ala Glu Val Pro Gly Leu Ser Ile Asn Phe 
 385                390                395                400
Ala Lys Val Leu His Gly Glu Gln Tyr Leu Glu Leu Tyr Lys Pro Leu 
                 405                410                415
Pro Arg Ser Gly Glu Leu Lys Cys Glu Ala Val Ile Ala Asp Ile Leu 
             420                425                430
Asp Lys Gly Ser Gly Ile Val Ile Val Met Asp Val Tyr Ser Tyr Ser 
         435                440                445
Gly Lys Glu Leu Ile Cys Tyr Asn Gln Phe Ser Val Phe Val Val Gly 
     450                455                460
Ser Gly Gly Phe Gly Gly Lys Arg Thr Ser Glu Lys Leu Lys Ala Ala 
 465                470                475                480
Val Ala Val Pro Ser Arg Pro Pro Asp Ala Val Leu Arg Asp Thr Thr 
                 485                490                495
Ser Leu Asn Gln Ala Ala Leu Tyr Arg Leu Ser Gly Asp Ser Asn Pro 
             500                505                510
Leu His Ile Asp Pro Ser Phe Ala Ser Ile Ala Gly Phe Glu Lys Pro 
         515                520                525
Ile Leu His Gly Leu Cys Thr Phe Gly Phe Ser Ala Arg His Val Leu 
     530                535                540
Gln Gln Phe Ala Asp Asn Asp Val Ser Arg Phe Lys Ala Ile Lys Val 
 545                550                555                560
Arg Phe Ala Lys Pro Val Tyr Pro Gly Gln Thr Leu Gln Thr Glu Met 
                 565                570                575
Trp Lys Glu Gly Asn Arg Ile His Phe Gln Thr Lys Val Gln Glu Thr 
             580                585                590
Gly Asp Ile Val Ile Ser Asn Ala Tyr Val Asp Leu Val Pro Thr Ser 
         595                600                605
Gly Val Ser Ala Gln Thr Pro Ser Glu Gly Gly Ala Leu Gln Ser Ala 
     610                615                620
Leu Val Phe Gly Glu Ile Gly Arg Arg Leu Lys Asp Val Gly Arg Glu 
 625                630                635                640
Val Val Lys Lys Val Asn Ala Val Phe Glu Trp His Ile Thr Lys Asn 
                 645                650                655
Gly Asn Val Ala Ala Lys Trp Thr Ile Asp Leu Lys Asn Gly Ser Gly 
             660                665                670
Glu Val Tyr Gln Gly Pro Ala Lys Gly Ser Ala Asp Thr Thr Ile Thr 
         675                680                685
Ile Ser Asp Glu Asp Phe Met Glu Val Val Leu Gly Lys Leu Asn Pro 
     690                695                700
Gln Asn Ala Phe Phe Ser Gly Arg Leu Lys Ala Arg Gly Asn Ile Met 
 705                710                715                720
Leu Ser Gln Lys Leu Gln Met Ile Leu Lys Asp Tyr Ala Lys Leu 
                 725                730                735



<210> 7875
<211> 2593
<212> DNA
<213> Homo sapiens
<308> NM_000414
<400> 7875

ggccagcgc  tctgcttgt  cgtgtgtgt  tcgttgcag  ccttattca  gggctcacc  60
ctgaggttc  acgggcggg  ggtactggt  accggcgcg  gggcaggat  gggccgagc  120
tatgccctg  cttttgcag  aagaggagc  ttagttgtt  tgaatgatt  gggagggga  180
ttcaaagga  ttggtaaag  ctccttagc  gctgataag  ttgttgaag  aataagaag  240
agaggtgga  aagcagtgg  caactatga  tcagtggaa  aaggagaga  ggttgtgaa  300
acagccctg  atgcttttg  aagaataga  gttgtggtc  acaatgctg  aattctgag  360
gatcgttcc  ttgctagga  aagtgatga  gactgggat  taatccaca  agttcattt  420
cggggttca  tccaagtga  acgggcagc  tgggaacac  tgaagaaac  gaagtatgg  480
aggattatt  tgacttcat  agcttcagg  atatatggc  actttggcc  ggccaatta  540
agtgctgca  agttgggtc  tctgggcct  gcaaattct  ttgcaattg  aggcaggaa  600
agcaacatt  attgtaaca  cattgctcc  aatgcggga  cacggatga  tcagacagt  660
atgcctgaa  atcttgtgg  agccctgaa  ccagagtat  tggcacctc  tgtcctttg  720
ctttgtcac  agagttgtg  ggagaatgg  ggcttgttt  aggttggag  aggatggat  780
ggaaaatta  gctgggagc  gactcttgg  gctattgta  gacaaaaga  tcacccaat  840
actcctgag  cagtcaagg  taactggaa  aagatctgt  actttgaga  tgccagcaa  900
cctcagagt  tccaagaat  aactggcag  ataattgaa  ttctgagta  aatagattc  960
gaaggagga  tttcagcaa  tcatactag  cgtgcaacg  ctacagcaa  atcaggatt  1020
gctggagct  ttggccaga  actccctcc  ttttcttat  cttatacgg  actggaagc  1080
attatgtat  cccttggag  gggagcgtc  atcaaggat  caaaagatt  gaaatttat  1140
tatgaagga  gttctgatt  ctcctgttt  cccaccttc  gagttatca  aggtcagaa  1200
tctatgatg  gtggaggat  agcagaaat  cctggactt  caatcaact  tgcaaaggt  1260
cttcatgga  agcagtact  agagttata  aaaccactt  ccagagcag  aaaattaaa  1320
tgtgaagca  ttgttgctg  tgtcctaga  aaaggatcc  gtgtagtga  tattatgga  1380
gtctattct  attctgaga  ggaacttat  tgccacaat  agttctctc  ctttcttgt  1440
ggctctgga  gctttggtg  aaaacggac  tcagacaaa  tcaaggtag  tgtagccat  1500
cctaataga  ctcctgatg  tgtacttac  gataccacc  ctcttaatc  ggctgcttt  1560
taccgcctc  gtggagact  gaatccctt  cacattgat  ctaactttg  tagtctagc  1620
ggttttgac  agcccatat  acatggatt  tgtacattt  gattttctg  caggcgtgt  1680
ttacagcag  ttgcagata  tgatgtgtc  agattcaag  caattaagg  tcgttttgc  1740
aaaccagta  atccaggac  aactctaca  actgagatg  ggaaggaag  aaacagaat  1800
cattttcaa  ccaaggtcc  agaaactgg  gacattgtc  tttcaaatg  atatgtgga  1860
cttgcacca  catctggta  ttcagctaa  acaccctct  agggcggga  gcttcagag  1920
acctttgta  ttgaggaaa  aggacgccg  ctaaaggat  ttgggcctg  ggtggtgaa  1980
aaagtaaat  ctgtatttg  gtggcatat  accaaaggc  gaaatattg  ggctaagtg  2040
actattgac  tgaaaagtg  ttctggaaa  gtgtaccaa  gccctgcaa  aggtgctgc  2100
gatacaaca  tcatacttt  agatgaaga  ttcatggag  tggtcctgg  caagcttga  2160
cctcagaag  cattcttta  tggcaggct  aaggccaga  ggaacatca  gctgagcca  2220
aaacttcag  tgattctta  agactacgc  aagctctga  gggcacact  cactattaa  2280
aaaaatgga  tcattaaat  ctctcttca  ccaaatatg  ttgattatt  tgcaaaagt  2340
attagaact  agatgcagg  gaaattgct  aacattttc  gatatcaga  aactgcaga  2400
tttcatttt  tactaattt  catgtatca  tatttttac  aggaactat  tataagcta  2460
cacatgatt  tccttctgt  cttagatct  tatcttcat  ataaaaaat  ttgcccaag  2520
cctgtttcc  tagaatttg  gatagcatt  ataagttga  aggaaaatt  aatcaataa  2580
ggcctttga  acc  2593



<210> 7876
<211> 736
<212> PRT
<213> Homo sapiens
<308> P51659
<400> 7876

Met Gly Ser Pro Leu Arg Phe Asp Gly Arg Val Val Leu Val Thr Gly 
  1               5                  10                  15
Ala Gly Ala Gly Leu Gly Arg Ala Tyr Ala Leu Ala Phe Ala Glu Arg 
             20                  25                  30
Gly Ala Leu Val Val Val Asn Asp Leu Gly Gly Asp Phe Lys Gly Val 
         35                  40                  45
Gly Lys Gly Ser Leu Ala Ala Asp Lys Val Val Glu Glu Ile Arg Arg 
     50                  55                  60
Arg Gly Gly Lys Ala Val Ala Asn Tyr Asp Ser Val Glu Glu Gly Glu 
 65                  70                  75                  80
Lys Val Val Lys Thr Ala Leu Asp Ala Phe Gly Arg Ile Asp Val Val 
                 85                  90                  95
Val Asn Asn Ala Gly Ile Leu Arg Asp Arg Ser Phe Ala Arg Ile Ser 
             100                105                110
Asp Glu Asp Trp Asp Ile Ile His Arg Val His Leu Arg Gly Ser Phe 
         115                120                125
Gln Val Thr Arg Ala Ala Trp Glu His Met Lys Lys Gln Lys Tyr Gly 
     130                135                140
Arg Ile Ile Met Thr Ser Ser Ala Ser Gly Ile Tyr Gly Asn Phe Gly 
 145                150                155                160
Gln Ala Asn Tyr Ser Ala Ala Lys Leu Gly Leu Leu Gly Leu Ala Asn 
                 165                170                175
Ser Leu Ala Ile Glu Gly Arg Lys Ser Asn Ile His Cys Asn Thr Ile 
             180                185                190
Ala Pro Asn Ala Gly Ser Arg Met Thr Gln Thr Val Met Pro Glu Asp 
         195                200                205
Leu Val Glu Ala Leu Lys Pro Glu Tyr Val Ala Pro Leu Val Leu Trp 
     210                215                220
Leu Cys His Glu Ser Cys Glu Glu Asn Gly Gly Leu Phe Glu Val Gly 
 225                230                235                240
Ala Gly Trp Ile Gly Lys Leu Arg Trp Glu Arg Thr Leu Gly Ala Ile 
                 245                250                255
Val Arg Gln Lys Asn His Pro Met Thr Pro Glu Ala Val Lys Ala Asn 
             260                265                270
Trp Lys Lys Ile Cys Asp Phe Glu Asn Ala Ser Lys Pro Gln Ser Ile 
         275                280                285
Gln Glu Ser Thr Gly Ser Ile Ile Glu Val Leu Ser Lys Ile Asp Ser 
     290                295                300
Glu Gly Gly Val Ser Ala Asn His Thr Ser Arg Ala Thr Ser Thr Ala 
 305                310                315                320
Thr Ser Gly Phe Ala Gly Ala Ile Gly Gln Lys Leu Pro Pro Phe Ser 
                 325                330                335
Tyr Ala Tyr Thr Glu Leu Glu Ala Ile Met Tyr Ala Leu Gly Val Gly 
             340                345                350
Ala Ser Ile Lys Asp Pro Lys Asp Leu Lys Phe Ile Tyr Glu Gly Ser 
         355                360                365
Ser Asp Phe Ser Cys Leu Pro Thr Phe Gly Val Ile Ile Gly Gln Lys 
     370                375                380
Ser Met Met Gly Gly Gly Leu Ala Glu Ile Pro Gly Leu Ser Ile Asn 
 385                390                395                400
Phe Ala Lys Val Leu His Gly Glu Gln Tyr Leu Glu Leu Tyr Lys Pro 
                 405                410                415
Leu Pro Arg Ala Gly Lys Leu Lys Cys Glu Ala Val Val Ala Asp Val 
             420                425                430
Leu Asp Lys Gly Ser Gly Val Val Ile Ile Met Asp Val Tyr Ser Tyr 
         435                440                445
Ser Glu Lys Glu Leu Ile Cys His Asn Gln Phe Ser Leu Phe Leu Val 
     450                455                460
Gly Ser Gly Gly Phe Gly Gly Lys Arg Thr Ser Asp Lys Val Lys Val 
 465                470                475                480
Ala Val Ala Ile Pro Asn Arg Pro Pro Asp Ala Val Leu Thr Asp Thr 
                 485                490                495
Thr Ser Leu Asn Gln Ala Ala Leu Tyr Arg Leu Ser Gly Asp Trp Asn 
             500                505                510
Pro Leu His Ile Asp Pro Asn Phe Ala Ser Leu Ala Gly Phe Asp Lys 
         515                520                525
Pro Ile Leu His Gly Leu Cys Thr Phe Gly Phe Ser Ala Arg Arg Val 
     530                535                540
Leu Gln Gln Phe Ala Asp Asn Asp Val Ser Arg Phe Lys Ala Ile Lys 
 545                550                555                560
Ala Arg Phe Ala Lys Pro Val Tyr Pro Gly Gln Thr Leu Gln Thr Glu 
                 565                570                575
Met Trp Lys Glu Gly Asn Arg Ile His Phe Gln Thr Lys Val Gln Glu 
             580                585                590
Thr Gly Asp Ile Val Ile Ser Asn Ala Tyr Val Asp Leu Ala Pro Thr 
         595                600                605
Ser Gly Thr Ser Ala Lys Thr Pro Ser Glu Gly Gly Lys Leu Gln Ser 
     610                615                620
Thr Phe Val Phe Glu Glu Ile Gly Arg Arg Leu Lys Asp Ile Gly Pro 
 625                630                635                640
Glu Val Val Lys Lys Val Asn Ala Val Phe Glu Trp His Ile Thr Lys 
                 645                650                655
Gly Gly Asn Ile Gly Ala Lys Trp Thr Ile Asp Leu Lys Ser Gly Ser 
             660                665                670
Gly Lys Val Tyr Gln Gly Pro Ala Lys Gly Ala Ala Asp Thr Thr Ile 
         675                680                685
Ile Leu Ser Asp Glu Asp Phe Met Glu Val Val Leu Gly Lys Leu Asp 
     690                695                700
Pro Gln Lys Ala Phe Phe Ser Gly Arg Leu Lys Ala Arg Gly Asn Ile 
 705                710                715                720
Met Leu Ser Gln Lys Leu Gln Met Ile Leu Lys Asp Tyr Ala Lys Leu 
                 725                730                735



<210> 7877
<211> 2480
<212> DNA
<213> Rattus norvegicus
<308> S83279
<400> 7877

gaattcggc  cgagtagac  catggcttc  cctctgagg  tcgacgggc  tgtggtcct  60
gtcaccggc  ccgggggag  gttgggcag  gcttatgcc  tggcttttg  agaaagagg  120
gcattagtt  ttgtgaatg  cttaggagg  gacttcaaa  gcgttggga  aggctcttc  180
gccgcagac  aggtcgtgg  agaaataag  aggagaggc  ggaaagcgg  ggccaatta  240
gattcagtc  aagcaggcg  gaagcttgt  aagacagca  tggacacat  cggcagaat  300
gatgttgtg  tgaacaatg  tgggatcct  agggaccgt  ccttctcta  gataagtga  360
gaagactgg  atataattc  aagagttca  ttgcggggc  ccttccaag  gacccgggc  420
gcatgggat  atatgaaga  gcagaatta  ggaagaatc  ttatgacgg  ctcagcttc  480
ggaatatac  gcaactttg  ccaggcaaa  tatagtgct  caaagctgg  ccttctggg  540
ctcgccaat  ctctcgtga  tgaaggcag  aagaacaac  ttcattgta  caccattgc  600
ccaaacgct  ggtcacgga  gacagagac  gtgatgcca  aagacctcg  tgaagccct  660
aagccagag  atgtggcac  gctggtcct  tggctttgc  atgagagct  tgaggaaaa  720
ggtggcttg  ttgaggttg  agcaggatg  attggaaaa  tgcgctggg  gaggaccct  780
ggagccatt  tcaggaagc  gaatcagcc  atgactccc  aggcagtga  ggacaactg  840
gtgaagatc  gtgacttca  caatgccag  aagccgaag  gcattcaag  gtccacagg  900
ggtataatc  aagttttac  taaaataga  tcagaagga  tctcacaaa  tcacaccgg  960
caagtggca  ctgcagatg  atcaggatt  gctggcgtc  ttggccaca  acttccttc  1020
ttttcttct  catatacgg  actgcagtg  attatgtat  ccctcggag  aggagcttc  1080
gtcaaaaat  caaaggact  gaagtttgt  tatgaaggg  gtgctgact  ctcctgttt  1140
cctacattt  gagtcattg  cgctcagaa  tccttgatg  gtggaggct  agcagaggt  1200
cctgggctg  caatcaact  tgcaaaggt  cttcatggg  agcagtact  ggagttgta  1260
aagccactt  cccgatcag  ggaattaaa  tgtgaagca  ttattgctg  catcctgga  1320
aaaggctct  gcatagtga  tgttatgga  gtctattct  attctggca  ggaacttat  1380
tgctataat  agttctctg  cttcgttgt  ggctctgga  gctttggtg  aaaacggac  1440
tcagaaaaa  tcaaagcag  tgtagccgt  ccaagtcgg  ctccagatg  tgtactgag  1500
gataccact  cactgaatc  ggccgctct  taccgcctc  gtggagact  gaatccttt  1560
cacattgac  cgagctttg  gagcattgc  ggttttgag  aacccatat  acacggatt  1620
tgtactttt  ggttttctg  aaggcatgt  ttacagcag  ttgcggata  tgatgtgtc  1680
agattcaag  ccattaagg  tcgttttgc  aaaccagtg  atccaggac  aactctaca  1740
actgagatg  ggaaggaag  aaacagaat  cattttcaa  ccaaggtcc  agagactgg  1800
gacattgtc  tttccaatg  atatgtgga  cttgttcct  catctggag  ttccgctca  1860
acaccttct  agggtggag  actgcagag  gctcttgta  ttggggaaa  aggtcgacg  1920
ctcaaggat  ttggacgtg  ggtggtaaa  aaagtaaat  ctgtatttg  atggcatat  1980
acgaaaaat  ggaatgttg  agccaagtg  accattgac  tgaagaacg  ctctggaga  2040
gtttaccaa  gccctgcca  aggctctgc  gacacgacc  tcacaattt  tgatgagga  2100
ttcatggaa  tggtcctgg  caagcttaa  ccacagaat  ccttcttca  tggcagact  2160
aaggcccga  gaaacatca  gctgagcca  aagctacag  tgattctga  agactatgc  2220
aagctctga  ggacccact  cgtgcttta  taaaaccag  atcattacg  tctgtctac  2280
cagtcatgc  ccagccttc  ttgaaacga  ccacggtaa  gtgcagcag  aattgctta  2340
cattttcag  ttcagataa  tttcagatt  tcattttct  ctaattttt  acatattat  2400
tttacaagg  actgtaatc  agctagcaa  taattgttc  gttcataga  ctgtatctt  2460
ataaaaaaa  aaaaaaaaaa  2480



<210> 7878
<211> 735
<212> PRT
<213> Rattus norvegicus
<308> AAB49519
<400> 7878

Met Ala Ser Pro Leu Arg Phe Asp Gly Arg Val Val Leu Val Thr Gly 
  1               5                  10                  15
Ala Gly Gly Gly Leu Gly Arg Ala Tyr Ala Leu Ala Phe Ala Glu Arg 
             20                  25                  30
Gly Ala Leu Val Val Val Asn Asp Leu Gly Gly Asp Phe Lys Gly Val 
         35                  40                  45
Gly Lys Gly Ser Ser Ala Ala Asp Lys Val Val Glu Glu Ile Arg Arg 
     50                  55                  60
Arg Gly Gly Lys Ala Val Ala Asn Tyr Asp Ser Val Glu Ala Gly Glu 
 65                  70                  75                  80
Lys Leu Val Lys Thr Ala Leu Asp Thr Phe Gly Arg Ile Asp Val Val 
                 85                  90                  95
Val Asn Asn Ala Gly Ile Leu Arg Asp Arg Ser Phe Ser Arg Ile Ser 
             100                105                110
Asp Glu Asp Trp Asp Ile Ile Gln Arg Val His Leu Arg Gly Ser Phe 
         115                120                125
Gln Val Thr Arg Ala Ala Trp Asp His Met Lys Lys Gln Asn Tyr Gly 
     130                135                140
Arg Ile Ile Met Thr Ala Ser Ala Ser Gly Ile Tyr Gly Asn Phe Gly 
 145                150                155                160
Gln Ala Asn Tyr Ser Ala Ala Lys Leu Gly Leu Leu Gly Leu Ala Asn 
                 165                170                175
Thr Leu Val Ile Glu Gly Arg Lys Asn Asn Ile His Cys Asn Thr Ile 
             180                185                190
Ala Pro Asn Ala Gly Ser Arg Met Thr Glu Thr Val Met Pro Glu Asp 
         195                200                205
Leu Val Glu Ala Leu Lys Pro Glu Tyr Val Ala Pro Leu Val Leu Trp 
     210                215                220
Leu Cys His Glu Ser Cys Glu Glu Asn Gly Gly Leu Phe Glu Val Gly 
 225                230                235                240
Ala Gly Trp Ile Gly Lys Leu Arg Trp Glu Arg Thr Leu Gly Ala Ile 
                 245                250                255
Val Arg Lys Arg Asn Gln Pro Met Thr Pro Glu Ala Val Arg Asp Asn 
             260                265                270
Trp Val Lys Ile Cys Asp Phe Ser Asn Ala Ser Lys Pro Lys Ser Ile 
         275                280                285
Gln Glu Ser Thr Gly Gly Ile Ile Glu Val Leu His Lys Ile Asp Ser 
     290                295                300
Glu Gly Ile Ser Gln Asn His Thr Gly Gln Val Ala Ser Ala Asp Ala 
 305                310                315                320
Ser Gly Phe Ala Gly Val Val Gly His Lys Leu Pro Ser Phe Ser Ser 
                 325                330                335
Ser Tyr Thr Glu Leu Gln Cys Ile Met Tyr Ala Leu Gly Val Gly Ala 
             340                345                350
Ser Val Lys Asn Pro Lys Asp Leu Lys Phe Val Tyr Glu Gly Ser Ala 
         355                360                365
Asp Phe Ser Cys Leu Pro Thr Phe Gly Val Ile Val Ala Gln Lys Ser 
     370                375                380
Leu Met Ser Gly Gly Leu Ala Glu Val Pro Gly Leu Ser Ile Asn Phe 
 385                390                395                400
Ala Lys Val Leu His Gly Glu Gln Tyr Leu Glu Leu Tyr Lys Pro Leu 
                 405                410                415
Pro Arg Ser Gly Glu Leu Lys Cys Glu Ala Val Ile Ala Asp Ile Leu 
             420                425                430
Asp Lys Gly Ser Gly Ile Val Ile Val Met Asp Val Tyr Ser Tyr Ser 
         435                440                445
Gly Lys Glu Leu Ile Cys Tyr Asn Gln Phe Ser Val Phe Val Val Gly 
     450                455                460
Ser Gly Gly Phe Gly Gly Lys Arg Thr Ser Glu Lys Leu Lys Ala Ala 
 465                470                475                480
Val Ala Val Pro Ser Arg Pro Pro Asp Ala Val Leu Arg Asp Thr Thr 
                 485                490                495
Ser Leu Asn Gln Ala Ala Leu Tyr Arg Leu Ser Gly Asp Ser Asn Pro 
             500                505                510
Leu His Ile Asp Pro Ser Phe Ala Ser Ile Ala Gly Phe Glu Lys Pro 
         515                520                525
Ile Leu His Gly Leu Cys Thr Phe Gly Phe Ser Ala Arg His Val Leu 
     530                535                540
Gln Gln Phe Ala Asp Asn Asp Val Ser Arg Phe Lys Ala Ile Lys Val 
 545                550                555                560
Arg Phe Ala Lys Pro Val Tyr Pro Gly Gln Thr Leu Gln Thr Glu Met 
                 565                570                575
Trp Lys Glu Gly Asn Arg Ile His Phe Gln Thr Lys Val Gln Glu Thr 
             580                585                590
Gly Asp Ile Val Ile Ser Asn Ala Tyr Val Asp Leu Val Pro Thr Ser 
         595                600                605
Gly Val Ser Ala Gln Thr Pro Ser Glu Gly Gly Ala Leu Gln Ser Ala 
     610                615                620
Leu Val Phe Gly Glu Ile Gly Arg Arg Leu Lys Asp Val Gly Arg Glu 
 625                630                635                640
Val Val Lys Lys Val Asn Ala Val Phe Glu Trp His Ile Thr Lys Asn 
                 645                650                655
Gly Asn Val Ala Ala Lys Trp Thr Ile Asp Leu Lys Asn Gly Ser Gly 
             660                665                670
Glu Val Tyr Gln Gly Pro Ala Lys Gly Ser Ala Asp Thr Thr Ile Thr 
         675                680                685
Ile Ser Asp Glu Asp Phe Met Glu Val Val Leu Gly Lys Leu Asn Pro 
     690                695                700
Gln Asn Ala Phe Phe Ser Gly Arg Leu Lys Ala Arg Gly Asn Ile Met 
 705                710                715                720
Leu Ser Gln Lys Leu Gln Met Ile Leu Lys Asp Tyr Ala Lys Leu 
                 725                730                735



<210> 7879
<211> 2593
<212> DNA
<213> Homo sapiens
<308> NM_000414
<400> 7879

ggccagcgc  tctgcttgt  cgtgtgtgt  tcgttgcag  ccttattca  gggctcacc  60
ctgaggttc  acgggcggg  ggtactggt  accggcgcg  gggcaggat  gggccgagc  120
tatgccctg  cttttgcag  aagaggagc  ttagttgtt  tgaatgatt  gggagggga  180
ttcaaagga  ttggtaaag  ctccttagc  gctgataag  ttgttgaag  aataagaag  240
agaggtgga  aagcagtgg  caactatga  tcagtggaa  aaggagaga  ggttgtgaa  300
acagccctg  atgcttttg  aagaataga  gttgtggtc  acaatgctg  aattctgag  360
gatcgttcc  ttgctagga  aagtgatga  gactgggat  taatccaca  agttcattt  420
cggggttca  tccaagtga  acgggcagc  tgggaacac  tgaagaaac  gaagtatgg  480
aggattatt  tgacttcat  agcttcagg  atatatggc  actttggcc  ggccaatta  540
agtgctgca  agttgggtc  tctgggcct  gcaaattct  ttgcaattg  aggcaggaa  600
agcaacatt  attgtaaca  cattgctcc  aatgcggga  cacggatga  tcagacagt  660
atgcctgaa  atcttgtgg  agccctgaa  ccagagtat  tggcacctc  tgtcctttg  720
ctttgtcac  agagttgtg  ggagaatgg  ggcttgttt  aggttggag  aggatggat  780
ggaaaatta  gctgggagc  gactcttgg  gctattgta  gacaaaaga  tcacccaat  840
actcctgag  cagtcaagg  taactggaa  aagatctgt  actttgaga  tgccagcaa  900
cctcagagt  tccaagaat  aactggcag  ataattgaa  ttctgagta  aatagattc  960
gaaggagga  tttcagcaa  tcatactag  cgtgcaacg  ctacagcaa  atcaggatt  1020
gctggagct  ttggccaga  actccctcc  ttttcttat  cttatacgg  actggaagc  1080
attatgtat  cccttggag  gggagcgtc  atcaaggat  caaaagatt  gaaatttat  1140
tatgaagga  gttctgatt  ctcctgttt  cccaccttc  gagttatca  aggtcagaa  1200
tctatgatg  gtggaggat  agcagaaat  cctggactt  caatcaact  tgcaaaggt  1260
cttcatgga  agcagtact  agagttata  aaaccactt  ccagagcag  aaaattaaa  1320
tgtgaagca  ttgttgctg  tgtcctaga  aaaggatcc  gtgtagtga  tattatgga  1380
gtctattct  attctgaga  ggaacttat  tgccacaat  agttctctc  ctttcttgt  1440
ggctctgga  gctttggtg  aaaacggac  tcagacaaa  tcaaggtag  tgtagccat  1500
cctaataga  ctcctgatg  tgtacttac  gataccacc  ctcttaatc  ggctgcttt  1560
taccgcctc  gtggagact  gaatccctt  cacattgat  ctaactttg  tagtctagc  1620
ggttttgac  agcccatat  acatggatt  tgtacattt  gattttctg  caggcgtgt  1680
ttacagcag  ttgcagata  tgatgtgtc  agattcaag  caattaagg  tcgttttgc  1740
aaaccagta  atccaggac  aactctaca  actgagatg  ggaaggaag  aaacagaat  1800
cattttcaa  ccaaggtcc  agaaactgg  gacattgtc  tttcaaatg  atatgtgga  1860
cttgcacca  catctggta  ttcagctaa  acaccctct  agggcggga  gcttcagag  1920
acctttgta  ttgaggaaa  aggacgccg  ctaaaggat  ttgggcctg  ggtggtgaa  1980
aaagtaaat  ctgtatttg  gtggcatat  accaaaggc  gaaatattg  ggctaagtg  2040
actattgac  tgaaaagtg  ttctggaaa  gtgtaccaa  gccctgcaa  aggtgctgc  2100
gatacaaca  tcatacttt  agatgaaga  ttcatggag  tggtcctgg  caagcttga  2160
cctcagaag  cattcttta  tggcaggct  aaggccaga  ggaacatca  gctgagcca  2220
aaacttcag  tgattctta  agactacgc  aagctctga  gggcacact  cactattaa  2280
aaaaatgga  tcattaaat  ctctcttca  ccaaatatg  ttgattatt  tgcaaaagt  2340
attagaact  agatgcagg  gaaattgct  aacattttc  gatatcaga  aactgcaga  2400
tttcatttt  tactaattt  catgtatca  tatttttac  aggaactat  tataagcta  2460
cacatgatt  tccttctgt  cttagatct  tatcttcat  ataaaaaat  ttgcccaag  2520
cctgtttcc  tagaatttg  gatagcatt  ataagttga  aggaaaatt  aatcaataa  2580
ggcctttga  acc  2593



<210> 7880
<211> 736
<212> PRT
<213> Homo sapiens
<308> P51659
<400> 7880

Met Gly Ser Pro Leu Arg Phe Asp Gly Arg Val Val Leu Val Thr Gly 
  1               5                  10                  15
Ala Gly Ala Gly Leu Gly Arg Ala Tyr Ala Leu Ala Phe Ala Glu Arg 
             20                  25                  30
Gly Ala Leu Val Val Val Asn Asp Leu Gly Gly Asp Phe Lys Gly Val 
         35                  40                  45
Gly Lys Gly Ser Leu Ala Ala Asp Lys Val Val Glu Glu Ile Arg Arg 
     50                  55                  60
Arg Gly Gly Lys Ala Val Ala Asn Tyr Asp Ser Val Glu Glu Gly Glu 
 65                  70                  75                  80
Lys Val Val Lys Thr Ala Leu Asp Ala Phe Gly Arg Ile Asp Val Val 
                 85                  90                  95
Val Asn Asn Ala Gly Ile Leu Arg Asp Arg Ser Phe Ala Arg Ile Ser 
             100                105                110
Asp Glu Asp Trp Asp Ile Ile His Arg Val His Leu Arg Gly Ser Phe 
         115                120                125
Gln Val Thr Arg Ala Ala Trp Glu His Met Lys Lys Gln Lys Tyr Gly 
     130                135                140
Arg Ile Ile Met Thr Ser Ser Ala Ser Gly Ile Tyr Gly Asn Phe Gly 
 145                150                155                160
Gln Ala Asn Tyr Ser Ala Ala Lys Leu Gly Leu Leu Gly Leu Ala Asn 
                 165                170                175
Ser Leu Ala Ile Glu Gly Arg Lys Ser Asn Ile His Cys Asn Thr Ile 
             180                185                190
Ala Pro Asn Ala Gly Ser Arg Met Thr Gln Thr Val Met Pro Glu Asp 
         195                200                205
Leu Val Glu Ala Leu Lys Pro Glu Tyr Val Ala Pro Leu Val Leu Trp 
     210                215                220
Leu Cys His Glu Ser Cys Glu Glu Asn Gly Gly Leu Phe Glu Val Gly 
 225                230                235                240
Ala Gly Trp Ile Gly Lys Leu Arg Trp Glu Arg Thr Leu Gly Ala Ile 
                 245                250                255
Val Arg Gln Lys Asn His Pro Met Thr Pro Glu Ala Val Lys Ala Asn 
             260                265                270
Trp Lys Lys Ile Cys Asp Phe Glu Asn Ala Ser Lys Pro Gln Ser Ile 
         275                280                285
Gln Glu Ser Thr Gly Ser Ile Ile Glu Val Leu Ser Lys Ile Asp Ser 
     290                295                300
Glu Gly Gly Val Ser Ala Asn His Thr Ser Arg Ala Thr Ser Thr Ala 
 305                310                315                320
Thr Ser Gly Phe Ala Gly Ala Ile Gly Gln Lys Leu Pro Pro Phe Ser 
                 325                330                335
Tyr Ala Tyr Thr Glu Leu Glu Ala Ile Met Tyr Ala Leu Gly Val Gly 
             340                345                350
Ala Ser Ile Lys Asp Pro Lys Asp Leu Lys Phe Ile Tyr Glu Gly Ser 
         355                360                365
Ser Asp Phe Ser Cys Leu Pro Thr Phe Gly Val Ile Ile Gly Gln Lys 
     370                375                380
Ser Met Met Gly Gly Gly Leu Ala Glu Ile Pro Gly Leu Ser Ile Asn 
 385                390                395                400
Phe Ala Lys Val Leu His Gly Glu Gln Tyr Leu Glu Leu Tyr Lys Pro 
                 405                410                415
Leu Pro Arg Ala Gly Lys Leu Lys Cys Glu Ala Val Val Ala Asp Val 
             420                425                430
Leu Asp Lys Gly Ser Gly Val Val Ile Ile Met Asp Val Tyr Ser Tyr 
         435                440                445
Ser Glu Lys Glu Leu Ile Cys His Asn Gln Phe Ser Leu Phe Leu Val 
     450                455                460
Gly Ser Gly Gly Phe Gly Gly Lys Arg Thr Ser Asp Lys Val Lys Val 
 465                470                475                480
Ala Val Ala Ile Pro Asn Arg Pro Pro Asp Ala Val Leu Thr Asp Thr 
                 485                490                495
Thr Ser Leu Asn Gln Ala Ala Leu Tyr Arg Leu Ser Gly Asp Trp Asn 
             500                505                510
Pro Leu His Ile Asp Pro Asn Phe Ala Ser Leu Ala Gly Phe Asp Lys 
         515                520                525
Pro Ile Leu His Gly Leu Cys Thr Phe Gly Phe Ser Ala Arg Arg Val 
     530                535                540
Leu Gln Gln Phe Ala Asp Asn Asp Val Ser Arg Phe Lys Ala Ile Lys 
 545                550                555                560
Ala Arg Phe Ala Lys Pro Val Tyr Pro Gly Gln Thr Leu Gln Thr Glu 
                 565                570                575
Met Trp Lys Glu Gly Asn Arg Ile His Phe Gln Thr Lys Val Gln Glu 
             580                585                590
Thr Gly Asp Ile Val Ile Ser Asn Ala Tyr Val Asp Leu Ala Pro Thr 
         595                600                605
Ser Gly Thr Ser Ala Lys Thr Pro Ser Glu Gly Gly Lys Leu Gln Ser 
     610                615                620
Thr Phe Val Phe Glu Glu Ile Gly Arg Arg Leu Lys Asp Ile Gly Pro 
 625                630                635                640
Glu Val Val Lys Lys Val Asn Ala Val Phe Glu Trp His Ile Thr Lys 
                 645                650                655
Gly Gly Asn Ile Gly Ala Lys Trp Thr Ile Asp Leu Lys Ser Gly Ser 
             660                665                670
Gly Lys Val Tyr Gln Gly Pro Ala Lys Gly Ala Ala Asp Thr Thr Ile 
         675                680                685
Ile Leu Ser Asp Glu Asp Phe Met Glu Val Val Leu Gly Lys Leu Asp 
     690                695                700
Pro Gln Lys Ala Phe Phe Ser Gly Arg Leu Lys Ala Arg Gly Asn Ile 
 705                710                715                720
Met Leu Ser Gln Lys Leu Gln Met Ile Leu Lys Asp Tyr Ala Lys Leu 
                 725                730                735



<210> 7881
<211> 1444
<212> DNA
<213> Rattus norvegicus
<308> S83320
<400> 7881

agcagctct  taagaaggg  atgtcggct  ttacataac  ttcctctct  cttttgaca  60
actgtgtga  ggtccatct  ctgatcaca  atggagtgg  atggcttga  gatgataat  120
agcaccatg  agcctcagg  gtcaaatgg  ccgacatcc  atacaagca  tggaccctc  180
agcaacaac  gaaactgtc  ttctcccat  cagacaggc  ccgccacag  cgacagcaa  240
accaacctc  tcgtcaact  tttacccca  aatatgacc  aagaggaat  caggagtct  300
tttgggagc  ttggtgaaa  cgaatcctg  aaactcgtg  gagacaaaa  tacaggaca  360
agtttaggg  atggatttg  taactatat  gatccaaag  atgcagaga  agccatcaa  420
actttaaat  gactcagac  ccagaccaa  accataaag  tgtcgtacg  ccgtccgag  480
tcggcctca  tcagggatg  taacctgta  gttagtggc  ttcccaaga  catgaccca  540
aaggagctg  agcagcttt  ctctcagta  ggtcgcatc  tcacctcac  catcctggt  600
gatcaagtc  caggagtct  tagaggggt  ggattcatc  gctttgata  gaggattga  660
gcagaagaa  ccatcaaag  gctgaatgg  cagaagccc  gcggtgcta  agaaccgat  720
actgtgaag  ttgccaaca  ccccagcca  aagtccagc  aggccctgc  ctcccagct  780
taccagtcc  ccaacaggc  ataccctgg  cctctccac  accaggctc  aagattcag  840
ctggacaat  tgcttaata  ggcctatgg  gtaaagaga  tgatgtctg  accagtccc  900
ccttctgct  gtcccccca  gttctcccc  atcaccatt  acgggatga  aagtcttgt  960
ggaatgaac  tccctggtc  cacagggac  ggctggtgc  tcttcgtct  taacctgtc  1020
cctgattct  atgagagtg  cctctggca  ctctttggc  cctttggcg  agtgaacaa  1080
gtcaaggtc  tccgtgact  caacaccaa  aaatgcaag  gattcggct  tgtcaccat  1140
accaactac  atgaggcag  catggccat  gccagcctc  atggttacc  cctgggaga  1200
agagtgttg  aagtttcct  taaaaccaa  aaagcccac  agtcctgaa  ttctcaccc  1260
tacttatta  aaaatatat  taaatatat  cgaacaaaa  atgcgtgca  acacataca  1320
aaaagagag  gacaaactt  ccaaggctt  tattcaacc  tggacttta  aagcccgcg  1380
tgcctaagt  ttaaaacat  ggattatcc  gaggtgtac  aggaaagga  tttataatg  1440
ttag  1444



<210> 7882
<211> 373
<212> PRT
<213> Rattus norvegicus
<308> AAB50733
<400> 7882

Met Glu Pro Gln Val Ser Asn Gly Pro Thr Ser Asn Thr Ser Asn Gly 
  1               5                  10                  15
Pro Ser Ser Asn Asn Arg Asn Cys Pro Ser Pro Met Gln Thr Gly Ala 
             20                  25                  30
Ala Thr Asp Asp Ser Lys Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln 
         35                  40                  45
Asn Met Thr Gln Glu Glu Phe Arg Ser Leu Phe Gly Ser Ile Gly Glu 
     50                  55                  60
Ile Glu Ser Cys Lys Leu Val Arg Asp Lys Ile Thr Gly Gln Ser Leu 
 65                  70                  75                  80
Gly Tyr Gly Phe Val Asn Tyr Ile Asp Pro Lys Asp Ala Glu Lys Ala 
                 85                  90                  95
Ile Asn Thr Leu Asn Gly Leu Arg Leu Gln Thr Lys Thr Ile Lys Val 
             100                105                110
Ser Tyr Ala Arg Pro Ser Ser Ala Ser Ile Arg Asp Ala Asn Leu Tyr 
         115                120                125
Val Ser Gly Leu Pro Lys Thr Met Thr Gln Lys Glu Leu Glu Gln Leu 
     130                135                140
Phe Ser Gln Tyr Gly Arg Ile Ile Thr Ser Arg Ile Leu Val Asp Gln 
 145                150                155                160
Val Thr Gly Val Ser Arg Gly Val Gly Phe Ile Arg Phe Asp Lys Arg 
                 165                170                175
Ile Glu Ala Glu Glu Ala Ile Lys Gly Leu Asn Gly Gln Lys Pro Ser 
             180                185                190
Gly Ala Thr Glu Pro Ile Thr Val Lys Phe Ala Asn Asn Pro Ser Gln 
         195                200                205
Lys Ser Ser Gln Ala Leu Leu Ser Gln Leu Tyr Gln Ser Pro Asn Arg 
     210                215                220
Arg Tyr Pro Gly Pro Leu His His Gln Ala Gln Arg Phe Arg Leu Asp 
 225                230                235                240
Asn Leu Leu Asn Met Ala Tyr Gly Val Lys Arg Leu Met Ser Gly Pro 
                 245                250                255
Val Pro Pro Ser Ala Cys Pro Pro Arg Phe Ser Pro Ile Thr Ile Asp 
             260                265                270
Gly Met Thr Ser Leu Val Gly Met Asn Ile Pro Gly His Thr Gly Thr 
         275                280                285
Gly Trp Cys Ile Phe Val Tyr Asn Leu Ser Pro Asp Ser Asp Glu Ser 
     290                295                300
Val Leu Trp Gln Leu Phe Gly Pro Phe Gly Ala Val Asn Asn Val Lys 
 305                310                315                320
Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys Gly Phe Gly Phe Val 
                 325                330                335
Thr Met Thr Asn Tyr Asp Glu Ala Ala Met Ala Ile Ala Ser Leu Asn 
             340                345                350
Gly Tyr Arg Leu Gly Asp Arg Val Leu Gln Val Ser Phe Lys Thr Asn 
         355                360                365
Lys Ala His Lys Ser 
     370



<210> 7883
<211> 1591
<212> DNA
<213> Homo sapiens
<308> NM_021952
<400> 7883

tagaatcgg  ggtttcagc  cactgctcc  tttcttttt  ttctttctc  cccccgccc  60
cccccccaa  aataattga  ttgctttac  atcatccac  ctgtgtttt  tggatcttt  120
attatatat  acaatagta  tcattttaa  tatatattc  gaaatcttt  caaatttta  180
cagaagagt  gaagctctg  gagacccaa  atttgccaa  aagaatggt  atgataatt  240
gcaccatgg  gcctcaggt  tcaaatggt  cgacatcca  tacaagcaa  ggaccctcc  300
gcaacaaca  aaactgtcc  tctcccatg  aaacagggg  aaccacaga  gacagcaaa  360
ccaacctca  cgtcaacta  ttaccccag  atatgaccc  agaagaatt  aggagtctc  420
tcgggagca  tggtgaaat  gaatcctgc  aacttgtga  agacaaaat  acaggacag  480
gtttagggt  tggatttgt  aactatatt  atccaaagg  tgcagagaa  gccatcaac  540
ctttaaatg  actcagact  cagaccaaa  ccataaagg  ctcatatgc  cgtccgagc  600
ctgcctcaa  cagggatgc  aacctctat  ttagcggcc  tcccaaaac  atgacccag  660
aggaactgg  gcaactttt  tcgcaatac  gccgtatca  cacctcacg  atcctggtt  720
atcaagtca  aggagtgtc  agaggggtg  gattcatcc  ctttgataa  aggattgag  780
cagaagaag  catcaaagg  ctgaatggc  agaagccca  cggtgctac  gaaccgatt  840
ctgtgaagt  tgccaacaa  cccagccag  agtccagcc  ggccctgct  tcccagctc  900
accagtccc  taaccggcg  tacccaggt  cacttcacc  ccaggctca  aggttcagg  960
tggacaatt  gcttaatat  gcctatggc  taaagagac  gatgtctgg  ccagtcccc  1020
cttctgctt  ttcccccag  ttctcccca  ttaccattg  tggaatgac  agccttgtg  1080
gaatgaaca  ccctggtca  acaggaact  ggtggtgca  ctttgtcta  aacctgtcc  1140
ccgattccg  tgagagtgt  ctctggcag  tctttggcc  ctttggagc  gtgaacaac  1200
taaaggtga  tcgtgactt  aacaccaac  agtgcaagg  attcggctt  gtcaccatg  1260
ccaactatg  tgaggcggc  atggccatc  ccagcctca  cgggtaccg  ctgggagac  1320
gagtgttgc  agtttcctt  aaaaccaac  aagcccaca  gtcctgaat  tcccattct  1380
acttactaa  atatatata  aaatatata  gaacaaaac  cacgcgcgc  cacacacac  1440
tacacgaaa  agagagaaa  aaacttttc  aggcttata  tcaaccatg  actttataa  1500
ccagtgttg  ctaagtatt  aaacattgg  ttatcctga  gtgtaccag  aaaggattt  1560
ataatgctt  gaaaaaaaa  aaaaaaaaa  a  1591



<210> 7884
<211> 380
<212> PRT
<213> Homo sapiens
<308> P26378
<400> 7884

Met Val Met Ile Ile Ser Thr Met Glu Pro Gln Val Ser Asn Gly Pro 
  1               5                  10                  15
Thr Ser Asn Thr Ser Asn Gly Pro Ser Ser Asn Asn Arg Asn Cys Pro 
             20                  25                  30
Ser Pro Met Gln Thr Gly Ala Thr Thr Asp Asp Ser Lys Thr Asn Leu 
         35                  40                  45
Ile Val Asn Tyr Leu Pro Gln Asn Met Thr Gln Glu Glu Phe Arg Ser 
     50                  55                  60
Leu Phe Gly Ser Ile Gly Glu Ile Glu Ser Cys Lys Leu Val Arg Asp 
 65                  70                  75                  80
Lys Ile Thr Gly Gln Ser Leu Gly Tyr Gly Phe Val Asn Tyr Ile Asp 
                 85                  90                  95
Pro Lys Asp Ala Glu Lys Ala Ile Asn Thr Leu Asn Gly Leu Arg Leu 
             100                105                110
Gln Thr Lys Thr Ile Lys Val Ser Tyr Ala Arg Pro Ser Ser Ala Ser 
         115                120                125
Ile Arg Asp Ala Asn Leu Tyr Val Ser Gly Leu Pro Lys Thr Met Thr 
     130                135                140
Gln Lys Glu Leu Glu Gln Leu Phe Ser Gln Tyr Gly Arg Ile Ile Thr 
 145                150                155                160
Ser Arg Ile Leu Val Asp Gln Val Thr Gly Val Ser Arg Gly Val Gly 
                 165                170                175
Phe Ile Arg Phe Asp Lys Arg Ile Glu Ala Glu Glu Ala Ile Lys Gly 
             180                185                190
Leu Asn Gly Gln Lys Pro Ser Gly Ala Thr Glu Pro Ile Thr Val Lys 
         195                200                205
Phe Ala Asn Asn Pro Ser Gln Lys Ser Ser Gln Ala Leu Leu Ser Gln 
     210                215                220
Leu Tyr Gln Ser Pro Asn Arg Arg Tyr Pro Gly Pro Leu His His Gln 
 225                230                235                240
Ala Gln Arg Phe Arg Leu Asp Asn Leu Leu Asn Met Ala Tyr Gly Val 
                 245                250                255
Lys Arg Leu Met Ser Gly Pro Val Pro Pro Ser Ala Cys Ser Pro Arg 
             260                265                270
Phe Ser Pro Ile Thr Ile Asp Gly Met Thr Ser Leu Val Gly Met Asn 
         275                280                285
Ile Pro Gly His Thr Gly Thr Gly Trp Cys Ile Phe Val Tyr Asn Leu 
     290                295                300
Ser Pro Asp Ser Asp Glu Ser Val Leu Trp Gln Leu Phe Gly Pro Phe 
 305                310                315                320
Gly Ala Val Asn Asn Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys 
                 325                330                335
Cys Lys Gly Phe Gly Phe Val Thr Met Thr Asn Tyr Asp Glu Ala Ala 
             340                345                350
Met Ala Ile Ala Ser Leu Asn Gly Tyr Arg Leu Gly Asp Arg Val Leu 
         355                360                365
Gln Val Ser Phe Lys Thr Asn Lys Ala His Lys Ser 
     370                375                380



<210> 7885
<211> 1444
<212> DNA
<213> Rattus norvegicus
<308> S83320
<400> 7885

agcagctct  taagaaggg  atgtcggct  ttacataac  ttcctctct  cttttgaca  60
actgtgtga  ggtccatct  ctgatcaca  atggagtgg  atggcttga  gatgataat  120
agcaccatg  agcctcagg  gtcaaatgg  ccgacatcc  atacaagca  tggaccctc  180
agcaacaac  gaaactgtc  ttctcccat  cagacaggc  ccgccacag  cgacagcaa  240
accaacctc  tcgtcaact  tttacccca  aatatgacc  aagaggaat  caggagtct  300
tttgggagc  ttggtgaaa  cgaatcctg  aaactcgtg  gagacaaaa  tacaggaca  360
agtttaggg  atggatttg  taactatat  gatccaaag  atgcagaga  agccatcaa  420
actttaaat  gactcagac  ccagaccaa  accataaag  tgtcgtacg  ccgtccgag  480
tcggcctca  tcagggatg  taacctgta  gttagtggc  ttcccaaga  catgaccca  540
aaggagctg  agcagcttt  ctctcagta  ggtcgcatc  tcacctcac  catcctggt  600
gatcaagtc  caggagtct  tagaggggt  ggattcatc  gctttgata  gaggattga  660
gcagaagaa  ccatcaaag  gctgaatgg  cagaagccc  gcggtgcta  agaaccgat  720
actgtgaag  ttgccaaca  ccccagcca  aagtccagc  aggccctgc  ctcccagct  780
taccagtcc  ccaacaggc  ataccctgg  cctctccac  accaggctc  aagattcag  840
ctggacaat  tgcttaata  ggcctatgg  gtaaagaga  tgatgtctg  accagtccc  900
ccttctgct  gtcccccca  gttctcccc  atcaccatt  acgggatga  aagtcttgt  960
ggaatgaac  tccctggtc  cacagggac  ggctggtgc  tcttcgtct  taacctgtc  1020
cctgattct  atgagagtg  cctctggca  ctctttggc  cctttggcg  agtgaacaa  1080
gtcaaggtc  tccgtgact  caacaccaa  aaatgcaag  gattcggct  tgtcaccat  1140
accaactac  atgaggcag  catggccat  gccagcctc  atggttacc  cctgggaga  1200
agagtgttg  aagtttcct  taaaaccaa  aaagcccac  agtcctgaa  ttctcaccc  1260
tacttatta  aaaatatat  taaatatat  cgaacaaaa  atgcgtgca  acacataca  1320
aaaagagag  gacaaactt  ccaaggctt  tattcaacc  tggacttta  aagcccgcg  1380
tgcctaagt  ttaaaacat  ggattatcc  gaggtgtac  aggaaagga  tttataatg  1440
ttag  1444



<210> 7886
<211> 373
<212> PRT
<213> Rattus norvegicus
<308> AAB50733
<400> 7886

Met Glu Pro Gln Val Ser Asn Gly Pro Thr Ser Asn Thr Ser Asn Gly 
  1               5                  10                  15
Pro Ser Ser Asn Asn Arg Asn Cys Pro Ser Pro Met Gln Thr Gly Ala 
             20                  25                  30
Ala Thr Asp Asp Ser Lys Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln 
         35                  40                  45
Asn Met Thr Gln Glu Glu Phe Arg Ser Leu Phe Gly Ser Ile Gly Glu 
     50                  55                  60
Ile Glu Ser Cys Lys Leu Val Arg Asp Lys Ile Thr Gly Gln Ser Leu 
 65                  70                  75                  80
Gly Tyr Gly Phe Val Asn Tyr Ile Asp Pro Lys Asp Ala Glu Lys Ala 
                 85                  90                  95
Ile Asn Thr Leu Asn Gly Leu Arg Leu Gln Thr Lys Thr Ile Lys Val 
             100                105                110
Ser Tyr Ala Arg Pro Ser Ser Ala Ser Ile Arg Asp Ala Asn Leu Tyr 
         115                120                125
Val Ser Gly Leu Pro Lys Thr Met Thr Gln Lys Glu Leu Glu Gln Leu 
     130                135                140
Phe Ser Gln Tyr Gly Arg Ile Ile Thr Ser Arg Ile Leu Val Asp Gln 
 145                150                155                160
Val Thr Gly Val Ser Arg Gly Val Gly Phe Ile Arg Phe Asp Lys Arg 
                 165                170                175
Ile Glu Ala Glu Glu Ala Ile Lys Gly Leu Asn Gly Gln Lys Pro Ser 
             180                185                190
Gly Ala Thr Glu Pro Ile Thr Val Lys Phe Ala Asn Asn Pro Ser Gln 
         195                200                205
Lys Ser Ser Gln Ala Leu Leu Ser Gln Leu Tyr Gln Ser Pro Asn Arg 
     210                215                220
Arg Tyr Pro Gly Pro Leu His His Gln Ala Gln Arg Phe Arg Leu Asp 
 225                230                235                240
Asn Leu Leu Asn Met Ala Tyr Gly Val Lys Arg Leu Met Ser Gly Pro 
                 245                250                255
Val Pro Pro Ser Ala Cys Pro Pro Arg Phe Ser Pro Ile Thr Ile Asp 
             260                265                270
Gly Met Thr Ser Leu Val Gly Met Asn Ile Pro Gly His Thr Gly Thr 
         275                280                285
Gly Trp Cys Ile Phe Val Tyr Asn Leu Ser Pro Asp Ser Asp Glu Ser 
     290                295                300
Val Leu Trp Gln Leu Phe Gly Pro Phe Gly Ala Val Asn Asn Val Lys 
 305                310                315                320
Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys Gly Phe Gly Phe Val 
                 325                330                335
Thr Met Thr Asn Tyr Asp Glu Ala Ala Met Ala Ile Ala Ser Leu Asn 
             340                345                350
Gly Tyr Arg Leu Gly Asp Arg Val Leu Gln Val Ser Phe Lys Thr Asn 
         355                360                365
Lys Ala His Lys Ser 
     370



<210> 7887
<211> 1591
<212> DNA
<213> Homo sapiens
<308> NM_021952
<400> 7887

tagaatcgg  ggtttcagc  cactgctcc  tttcttttt  ttctttctc  cccccgccc  60
cccccccaa  aataattga  ttgctttac  atcatccac  ctgtgtttt  tggatcttt  120
attatatat  acaatagta  tcattttaa  tatatattc  gaaatcttt  caaatttta  180
cagaagagt  gaagctctg  gagacccaa  atttgccaa  aagaatggt  atgataatt  240
gcaccatgg  gcctcaggt  tcaaatggt  cgacatcca  tacaagcaa  ggaccctcc  300
gcaacaaca  aaactgtcc  tctcccatg  aaacagggg  aaccacaga  gacagcaaa  360
ccaacctca  cgtcaacta  ttaccccag  atatgaccc  agaagaatt  aggagtctc  420
tcgggagca  tggtgaaat  gaatcctgc  aacttgtga  agacaaaat  acaggacag  480
gtttagggt  tggatttgt  aactatatt  atccaaagg  tgcagagaa  gccatcaac  540
ctttaaatg  actcagact  cagaccaaa  ccataaagg  ctcatatgc  cgtccgagc  600
ctgcctcaa  cagggatgc  aacctctat  ttagcggcc  tcccaaaac  atgacccag  660
aggaactgg  gcaactttt  tcgcaatac  gccgtatca  cacctcacg  atcctggtt  720
atcaagtca  aggagtgtc  agaggggtg  gattcatcc  ctttgataa  aggattgag  780
cagaagaag  catcaaagg  ctgaatggc  agaagccca  cggtgctac  gaaccgatt  840
ctgtgaagt  tgccaacaa  cccagccag  agtccagcc  ggccctgct  tcccagctc  900
accagtccc  taaccggcg  tacccaggt  cacttcacc  ccaggctca  aggttcagg  960
tggacaatt  gcttaatat  gcctatggc  taaagagac  gatgtctgg  ccagtcccc  1020
cttctgctt  ttcccccag  ttctcccca  ttaccattg  tggaatgac  agccttgtg  1080
gaatgaaca  ccctggtca  acaggaact  ggtggtgca  ctttgtcta  aacctgtcc  1140
ccgattccg  tgagagtgt  ctctggcag  tctttggcc  ctttggagc  gtgaacaac  1200
taaaggtga  tcgtgactt  aacaccaac  agtgcaagg  attcggctt  gtcaccatg  1260
ccaactatg  tgaggcggc  atggccatc  ccagcctca  cgggtaccg  ctgggagac  1320
gagtgttgc  agtttcctt  aaaaccaac  aagcccaca  gtcctgaat  tcccattct  1380
acttactaa  atatatata  aaatatata  gaacaaaac  cacgcgcgc  cacacacac  1440
tacacgaaa  agagagaaa  aaacttttc  aggcttata  tcaaccatg  actttataa  1500
ccagtgttg  ctaagtatt  aaacattgg  ttatcctga  gtgtaccag  aaaggattt  1560
ataatgctt  gaaaaaaaa  aaaaaaaaa  a  1591



<210> 7888
<211> 380
<212> PRT
<213> Homo sapiens
<308> P26378
<400> 7888

Met Val Met Ile Ile Ser Thr Met Glu Pro Gln Val Ser Asn Gly Pro 
  1               5                  10                  15
Thr Ser Asn Thr Ser Asn Gly Pro Ser Ser Asn Asn Arg Asn Cys Pro 
             20                  25                  30
Ser Pro Met Gln Thr Gly Ala Thr Thr Asp Asp Ser Lys Thr Asn Leu 
         35                  40                  45
Ile Val Asn Tyr Leu Pro Gln Asn Met Thr Gln Glu Glu Phe Arg Ser 
     50                  55                  60
Leu Phe Gly Ser Ile Gly Glu Ile Glu Ser Cys Lys Leu Val Arg Asp 
 65                  70                  75                  80
Lys Ile Thr Gly Gln Ser Leu Gly Tyr Gly Phe Val Asn Tyr Ile Asp 
                 85                  90                  95
Pro Lys Asp Ala Glu Lys Ala Ile Asn Thr Leu Asn Gly Leu Arg Leu 
             100                105                110
Gln Thr Lys Thr Ile Lys Val Ser Tyr Ala Arg Pro Ser Ser Ala Ser 
         115                120                125
Ile Arg Asp Ala Asn Leu Tyr Val Ser Gly Leu Pro Lys Thr Met Thr 
     130                135                140
Gln Lys Glu Leu Glu Gln Leu Phe Ser Gln Tyr Gly Arg Ile Ile Thr 
 145                150                155                160
Ser Arg Ile Leu Val Asp Gln Val Thr Gly Val Ser Arg Gly Val Gly 
                 165                170                175
Phe Ile Arg Phe Asp Lys Arg Ile Glu Ala Glu Glu Ala Ile Lys Gly 
             180                185                190
Leu Asn Gly Gln Lys Pro Ser Gly Ala Thr Glu Pro Ile Thr Val Lys 
         195                200                205
Phe Ala Asn Asn Pro Ser Gln Lys Ser Ser Gln Ala Leu Leu Ser Gln 
     210                215                220
Leu Tyr Gln Ser Pro Asn Arg Arg Tyr Pro Gly Pro Leu His His Gln 
 225                230                235                240
Ala Gln Arg Phe Arg Leu Asp Asn Leu Leu Asn Met Ala Tyr Gly Val 
                 245                250                255
Lys Arg Leu Met Ser Gly Pro Val Pro Pro Ser Ala Cys Ser Pro Arg 
             260                265                270
Phe Ser Pro Ile Thr Ile Asp Gly Met Thr Ser Leu Val Gly Met Asn 
         275                280                285
Ile Pro Gly His Thr Gly Thr Gly Trp Cys Ile Phe Val Tyr Asn Leu 
     290                295                300
Ser Pro Asp Ser Asp Glu Ser Val Leu Trp Gln Leu Phe Gly Pro Phe 
 305                310                315                320
Gly Ala Val Asn Asn Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys 
                 325                330                335
Cys Lys Gly Phe Gly Phe Val Thr Met Thr Asn Tyr Asp Glu Ala Ala 
             340                345                350
Met Ala Ile Ala Ser Leu Asn Gly Tyr Arg Leu Gly Asp Arg Val Leu 
         355                360                365
Gln Val Ser Phe Lys Thr Asn Lys Ala His Lys Ser 
     370                375                380



<210> 7889
<211> 1444
<212> DNA
<213> Rattus norvegicus
<308> S83320
<400> 7889

agcagctct  taagaaggg  atgtcggct  ttacataac  ttcctctct  cttttgaca  60
actgtgtga  ggtccatct  ctgatcaca  atggagtgg  atggcttga  gatgataat  120
agcaccatg  agcctcagg  gtcaaatgg  ccgacatcc  atacaagca  tggaccctc  180
agcaacaac  gaaactgtc  ttctcccat  cagacaggc  ccgccacag  cgacagcaa  240
accaacctc  tcgtcaact  tttacccca  aatatgacc  aagaggaat  caggagtct  300
tttgggagc  ttggtgaaa  cgaatcctg  aaactcgtg  gagacaaaa  tacaggaca  360
agtttaggg  atggatttg  taactatat  gatccaaag  atgcagaga  agccatcaa  420
actttaaat  gactcagac  ccagaccaa  accataaag  tgtcgtacg  ccgtccgag  480
tcggcctca  tcagggatg  taacctgta  gttagtggc  ttcccaaga  catgaccca  540
aaggagctg  agcagcttt  ctctcagta  ggtcgcatc  tcacctcac  catcctggt  600
gatcaagtc  caggagtct  tagaggggt  ggattcatc  gctttgata  gaggattga  660
gcagaagaa  ccatcaaag  gctgaatgg  cagaagccc  gcggtgcta  agaaccgat  720
actgtgaag  ttgccaaca  ccccagcca  aagtccagc  aggccctgc  ctcccagct  780
taccagtcc  ccaacaggc  ataccctgg  cctctccac  accaggctc  aagattcag  840
ctggacaat  tgcttaata  ggcctatgg  gtaaagaga  tgatgtctg  accagtccc  900
ccttctgct  gtcccccca  gttctcccc  atcaccatt  acgggatga  aagtcttgt  960
ggaatgaac  tccctggtc  cacagggac  ggctggtgc  tcttcgtct  taacctgtc  1020
cctgattct  atgagagtg  cctctggca  ctctttggc  cctttggcg  agtgaacaa  1080
gtcaaggtc  tccgtgact  caacaccaa  aaatgcaag  gattcggct  tgtcaccat  1140
accaactac  atgaggcag  catggccat  gccagcctc  atggttacc  cctgggaga  1200
agagtgttg  aagtttcct  taaaaccaa  aaagcccac  agtcctgaa  ttctcaccc  1260
tacttatta  aaaatatat  taaatatat  cgaacaaaa  atgcgtgca  acacataca  1320
aaaagagag  gacaaactt  ccaaggctt  tattcaacc  tggacttta  aagcccgcg  1380
tgcctaagt  ttaaaacat  ggattatcc  gaggtgtac  aggaaagga  tttataatg  1440
ttag  1444



<210> 7890
<211> 373
<212> PRT
<213> Rattus norvegicus
<308> AAB50733
<400> 7890

Met Glu Pro Gln Val Ser Asn Gly Pro Thr Ser Asn Thr Ser Asn Gly 
  1               5                  10                  15
Pro Ser Ser Asn Asn Arg Asn Cys Pro Ser Pro Met Gln Thr Gly Ala 
             20                  25                  30
Ala Thr Asp Asp Ser Lys Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln 
         35                  40                  45
Asn Met Thr Gln Glu Glu Phe Arg Ser Leu Phe Gly Ser Ile Gly Glu 
     50                  55                  60
Ile Glu Ser Cys Lys Leu Val Arg Asp Lys Ile Thr Gly Gln Ser Leu 
 65                  70                  75                  80
Gly Tyr Gly Phe Val Asn Tyr Ile Asp Pro Lys Asp Ala Glu Lys Ala 
                 85                  90                  95
Ile Asn Thr Leu Asn Gly Leu Arg Leu Gln Thr Lys Thr Ile Lys Val 
             100                105                110
Ser Tyr Ala Arg Pro Ser Ser Ala Ser Ile Arg Asp Ala Asn Leu Tyr 
         115                120                125
Val Ser Gly Leu Pro Lys Thr Met Thr Gln Lys Glu Leu Glu Gln Leu 
     130                135                140
Phe Ser Gln Tyr Gly Arg Ile Ile Thr Ser Arg Ile Leu Val Asp Gln 
 145                150                155                160
Val Thr Gly Val Ser Arg Gly Val Gly Phe Ile Arg Phe Asp Lys Arg 
                 165                170                175
Ile Glu Ala Glu Glu Ala Ile Lys Gly Leu Asn Gly Gln Lys Pro Ser 
             180                185                190
Gly Ala Thr Glu Pro Ile Thr Val Lys Phe Ala Asn Asn Pro Ser Gln 
         195                200                205
Lys Ser Ser Gln Ala Leu Leu Ser Gln Leu Tyr Gln Ser Pro Asn Arg 
     210                215                220
Arg Tyr Pro Gly Pro Leu His His Gln Ala Gln Arg Phe Arg Leu Asp 
 225                230                235                240
Asn Leu Leu Asn Met Ala Tyr Gly Val Lys Arg Leu Met Ser Gly Pro 
                 245                250                255
Val Pro Pro Ser Ala Cys Pro Pro Arg Phe Ser Pro Ile Thr Ile Asp 
             260                265                270
Gly Met Thr Ser Leu Val Gly Met Asn Ile Pro Gly His Thr Gly Thr 
         275                280                285
Gly Trp Cys Ile Phe Val Tyr Asn Leu Ser Pro Asp Ser Asp Glu Ser 
     290                295                300
Val Leu Trp Gln Leu Phe Gly Pro Phe Gly Ala Val Asn Asn Val Lys 
 305                310                315                320
Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys Gly Phe Gly Phe Val 
                 325                330                335
Thr Met Thr Asn Tyr Asp Glu Ala Ala Met Ala Ile Ala Ser Leu Asn 
             340                345                350
Gly Tyr Arg Leu Gly Asp Arg Val Leu Gln Val Ser Phe Lys Thr Asn 
         355                360                365
Lys Ala His Lys Ser 
     370



<210> 7891
<211> 1591
<212> DNA
<213> Homo sapiens
<308> NM_021952
<400> 7891

tagaatcgg  ggtttcagc  cactgctcc  tttcttttt  ttctttctc  cccccgccc  60
cccccccaa  aataattga  ttgctttac  atcatccac  ctgtgtttt  tggatcttt  120
attatatat  acaatagta  tcattttaa  tatatattc  gaaatcttt  caaatttta  180
cagaagagt  gaagctctg  gagacccaa  atttgccaa  aagaatggt  atgataatt  240
gcaccatgg  gcctcaggt  tcaaatggt  cgacatcca  tacaagcaa  ggaccctcc  300
gcaacaaca  aaactgtcc  tctcccatg  aaacagggg  aaccacaga  gacagcaaa  360
ccaacctca  cgtcaacta  ttaccccag  atatgaccc  agaagaatt  aggagtctc  420
tcgggagca  tggtgaaat  gaatcctgc  aacttgtga  agacaaaat  acaggacag  480
gtttagggt  tggatttgt  aactatatt  atccaaagg  tgcagagaa  gccatcaac  540
ctttaaatg  actcagact  cagaccaaa  ccataaagg  ctcatatgc  cgtccgagc  600
ctgcctcaa  cagggatgc  aacctctat  ttagcggcc  tcccaaaac  atgacccag  660
aggaactgg  gcaactttt  tcgcaatac  gccgtatca  cacctcacg  atcctggtt  720
atcaagtca  aggagtgtc  agaggggtg  gattcatcc  ctttgataa  aggattgag  780
cagaagaag  catcaaagg  ctgaatggc  agaagccca  cggtgctac  gaaccgatt  840
ctgtgaagt  tgccaacaa  cccagccag  agtccagcc  ggccctgct  tcccagctc  900
accagtccc  taaccggcg  tacccaggt  cacttcacc  ccaggctca  aggttcagg  960
tggacaatt  gcttaatat  gcctatggc  taaagagac  gatgtctgg  ccagtcccc  1020
cttctgctt  ttcccccag  ttctcccca  ttaccattg  tggaatgac  agccttgtg  1080
gaatgaaca  ccctggtca  acaggaact  ggtggtgca  ctttgtcta  aacctgtcc  1140
ccgattccg  tgagagtgt  ctctggcag  tctttggcc  ctttggagc  gtgaacaac  1200
taaaggtga  tcgtgactt  aacaccaac  agtgcaagg  attcggctt  gtcaccatg  1260
ccaactatg  tgaggcggc  atggccatc  ccagcctca  cgggtaccg  ctgggagac  1320
gagtgttgc  agtttcctt  aaaaccaac  aagcccaca  gtcctgaat  tcccattct  1380
acttactaa  atatatata  aaatatata  gaacaaaac  cacgcgcgc  cacacacac  1440
tacacgaaa  agagagaaa  aaacttttc  aggcttata  tcaaccatg  actttataa  1500
ccagtgttg  ctaagtatt  aaacattgg  ttatcctga  gtgtaccag  aaaggattt  1560
ataatgctt  gaaaaaaaa  aaaaaaaaa  a  1591



<210> 7892
<211> 380
<212> PRT
<213> Homo sapiens
<308> P26378
<400> 7892

Met Val Met Ile Ile Ser Thr Met Glu Pro Gln Val Ser Asn Gly Pro 
  1               5                  10                  15
Thr Ser Asn Thr Ser Asn Gly Pro Ser Ser Asn Asn Arg Asn Cys Pro 
             20                  25                  30
Ser Pro Met Gln Thr Gly Ala Thr Thr Asp Asp Ser Lys Thr Asn Leu 
         35                  40                  45
Ile Val Asn Tyr Leu Pro Gln Asn Met Thr Gln Glu Glu Phe Arg Ser 
     50                  55                  60
Leu Phe Gly Ser Ile Gly Glu Ile Glu Ser Cys Lys Leu Val Arg Asp 
 65                  70                  75                  80
Lys Ile Thr Gly Gln Ser Leu Gly Tyr Gly Phe Val Asn Tyr Ile Asp 
                 85                  90                  95
Pro Lys Asp Ala Glu Lys Ala Ile Asn Thr Leu Asn Gly Leu Arg Leu 
             100                105                110
Gln Thr Lys Thr Ile Lys Val Ser Tyr Ala Arg Pro Ser Ser Ala Ser 
         115                120                125
Ile Arg Asp Ala Asn Leu Tyr Val Ser Gly Leu Pro Lys Thr Met Thr 
     130                135                140
Gln Lys Glu Leu Glu Gln Leu Phe Ser Gln Tyr Gly Arg Ile Ile Thr 
 145                150                155                160
Ser Arg Ile Leu Val Asp Gln Val Thr Gly Val Ser Arg Gly Val Gly 
                 165                170                175
Phe Ile Arg Phe Asp Lys Arg Ile Glu Ala Glu Glu Ala Ile Lys Gly 
             180                185                190
Leu Asn Gly Gln Lys Pro Ser Gly Ala Thr Glu Pro Ile Thr Val Lys 
         195                200                205
Phe Ala Asn Asn Pro Ser Gln Lys Ser Ser Gln Ala Leu Leu Ser Gln 
     210                215                220
Leu Tyr Gln Ser Pro Asn Arg Arg Tyr Pro Gly Pro Leu His His Gln 
 225                230                235                240
Ala Gln Arg Phe Arg Leu Asp Asn Leu Leu Asn Met Ala Tyr Gly Val 
                 245                250                255
Lys Arg Leu Met Ser Gly Pro Val Pro Pro Ser Ala Cys Ser Pro Arg 
             260                265                270
Phe Ser Pro Ile Thr Ile Asp Gly Met Thr Ser Leu Val Gly Met Asn 
         275                280                285
Ile Pro Gly His Thr Gly Thr Gly Trp Cys Ile Phe Val Tyr Asn Leu 
     290                295                300
Ser Pro Asp Ser Asp Glu Ser Val Leu Trp Gln Leu Phe Gly Pro Phe 
 305                310                315                320
Gly Ala Val Asn Asn Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys 
                 325                330                335
Cys Lys Gly Phe Gly Phe Val Thr Met Thr Asn Tyr Asp Glu Ala Ala 
             340                345                350
Met Ala Ile Ala Ser Leu Asn Gly Tyr Arg Leu Gly Asp Arg Val Leu 
         355                360                365
Gln Val Ser Phe Lys Thr Asn Lys Ala His Lys Ser 
     370                375                380



<210> 7893
<211> 1444
<212> DNA
<213> Rattus norvegicus
<308> S83320
<400> 7893

agcagctct  taagaaggg  atgtcggct  ttacataac  ttcctctct  cttttgaca  60
actgtgtga  ggtccatct  ctgatcaca  atggagtgg  atggcttga  gatgataat  120
agcaccatg  agcctcagg  gtcaaatgg  ccgacatcc  atacaagca  tggaccctc  180
agcaacaac  gaaactgtc  ttctcccat  cagacaggc  ccgccacag  cgacagcaa  240
accaacctc  tcgtcaact  tttacccca  aatatgacc  aagaggaat  caggagtct  300
tttgggagc  ttggtgaaa  cgaatcctg  aaactcgtg  gagacaaaa  tacaggaca  360
agtttaggg  atggatttg  taactatat  gatccaaag  atgcagaga  agccatcaa  420
actttaaat  gactcagac  ccagaccaa  accataaag  tgtcgtacg  ccgtccgag  480
tcggcctca  tcagggatg  taacctgta  gttagtggc  ttcccaaga  catgaccca  540
aaggagctg  agcagcttt  ctctcagta  ggtcgcatc  tcacctcac  catcctggt  600
gatcaagtc  caggagtct  tagaggggt  ggattcatc  gctttgata  gaggattga  660
gcagaagaa  ccatcaaag  gctgaatgg  cagaagccc  gcggtgcta  agaaccgat  720
actgtgaag  ttgccaaca  ccccagcca  aagtccagc  aggccctgc  ctcccagct  780
taccagtcc  ccaacaggc  ataccctgg  cctctccac  accaggctc  aagattcag  840
ctggacaat  tgcttaata  ggcctatgg  gtaaagaga  tgatgtctg  accagtccc  900
ccttctgct  gtcccccca  gttctcccc  atcaccatt  acgggatga  aagtcttgt  960
ggaatgaac  tccctggtc  cacagggac  ggctggtgc  tcttcgtct  taacctgtc  1020
cctgattct  atgagagtg  cctctggca  ctctttggc  cctttggcg  agtgaacaa  1080
gtcaaggtc  tccgtgact  caacaccaa  aaatgcaag  gattcggct  tgtcaccat  1140
accaactac  atgaggcag  catggccat  gccagcctc  atggttacc  cctgggaga  1200
agagtgttg  aagtttcct  taaaaccaa  aaagcccac  agtcctgaa  ttctcaccc  1260
tacttatta  aaaatatat  taaatatat  cgaacaaaa  atgcgtgca  acacataca  1320
aaaagagag  gacaaactt  ccaaggctt  tattcaacc  tggacttta  aagcccgcg  1380
tgcctaagt  ttaaaacat  ggattatcc  gaggtgtac  aggaaagga  tttataatg  1440
ttag  1444



<210> 7894
<211> 373
<212> PRT
<213> Rattus norvegicus
<308> AAB50733
<400> 7894

Met Glu Pro Gln Val Ser Asn Gly Pro Thr Ser Asn Thr Ser Asn Gly 
  1               5                  10                  15
Pro Ser Ser Asn Asn Arg Asn Cys Pro Ser Pro Met Gln Thr Gly Ala 
             20                  25                  30
Ala Thr Asp Asp Ser Lys Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln 
         35                  40                  45
Asn Met Thr Gln Glu Glu Phe Arg Ser Leu Phe Gly Ser Ile Gly Glu 
     50                  55                  60
Ile Glu Ser Cys Lys Leu Val Arg Asp Lys Ile Thr Gly Gln Ser Leu 
 65                  70                  75                  80
Gly Tyr Gly Phe Val Asn Tyr Ile Asp Pro Lys Asp Ala Glu Lys Ala 
                 85                  90                  95
Ile Asn Thr Leu Asn Gly Leu Arg Leu Gln Thr Lys Thr Ile Lys Val 
             100                105                110
Ser Tyr Ala Arg Pro Ser Ser Ala Ser Ile Arg Asp Ala Asn Leu Tyr 
         115                120                125
Val Ser Gly Leu Pro Lys Thr Met Thr Gln Lys Glu Leu Glu Gln Leu 
     130                135                140
Phe Ser Gln Tyr Gly Arg Ile Ile Thr Ser Arg Ile Leu Val Asp Gln 
 145                150                155                160
Val Thr Gly Val Ser Arg Gly Val Gly Phe Ile Arg Phe Asp Lys Arg 
                 165                170                175
Ile Glu Ala Glu Glu Ala Ile Lys Gly Leu Asn Gly Gln Lys Pro Ser 
             180                185                190
Gly Ala Thr Glu Pro Ile Thr Val Lys Phe Ala Asn Asn Pro Ser Gln 
         195                200                205
Lys Ser Ser Gln Ala Leu Leu Ser Gln Leu Tyr Gln Ser Pro Asn Arg 
     210                215                220
Arg Tyr Pro Gly Pro Leu His His Gln Ala Gln Arg Phe Arg Leu Asp 
 225                230                235                240
Asn Leu Leu Asn Met Ala Tyr Gly Val Lys Arg Leu Met Ser Gly Pro 
                 245                250                255
Val Pro Pro Ser Ala Cys Pro Pro Arg Phe Ser Pro Ile Thr Ile Asp 
             260                265                270
Gly Met Thr Ser Leu Val Gly Met Asn Ile Pro Gly His Thr Gly Thr 
         275                280                285
Gly Trp Cys Ile Phe Val Tyr Asn Leu Ser Pro Asp Ser Asp Glu Ser 
     290                295                300
Val Leu Trp Gln Leu Phe Gly Pro Phe Gly Ala Val Asn Asn Val Lys 
 305                310                315                320
Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys Gly Phe Gly Phe Val 
                 325                330                335
Thr Met Thr Asn Tyr Asp Glu Ala Ala Met Ala Ile Ala Ser Leu Asn 
             340                345                350
Gly Tyr Arg Leu Gly Asp Arg Val Leu Gln Val Ser Phe Lys Thr Asn 
         355                360                365
Lys Ala His Lys Ser 
     370



<210> 7895
<211> 1591
<212> DNA
<213> Homo sapiens
<308> NM_021952
<400> 7895

tagaatcgg  ggtttcagc  cactgctcc  tttcttttt  ttctttctc  cccccgccc  60
cccccccaa  aataattga  ttgctttac  atcatccac  ctgtgtttt  tggatcttt  120
attatatat  acaatagta  tcattttaa  tatatattc  gaaatcttt  caaatttta  180
cagaagagt  gaagctctg  gagacccaa  atttgccaa  aagaatggt  atgataatt  240
gcaccatgg  gcctcaggt  tcaaatggt  cgacatcca  tacaagcaa  ggaccctcc  300
gcaacaaca  aaactgtcc  tctcccatg  aaacagggg  aaccacaga  gacagcaaa  360
ccaacctca  cgtcaacta  ttaccccag  atatgaccc  agaagaatt  aggagtctc  420
tcgggagca  tggtgaaat  gaatcctgc  aacttgtga  agacaaaat  acaggacag  480
gtttagggt  tggatttgt  aactatatt  atccaaagg  tgcagagaa  gccatcaac  540
ctttaaatg  actcagact  cagaccaaa  ccataaagg  ctcatatgc  cgtccgagc  600
ctgcctcaa  cagggatgc  aacctctat  ttagcggcc  tcccaaaac  atgacccag  660
aggaactgg  gcaactttt  tcgcaatac  gccgtatca  cacctcacg  atcctggtt  720
atcaagtca  aggagtgtc  agaggggtg  gattcatcc  ctttgataa  aggattgag  780
cagaagaag  catcaaagg  ctgaatggc  agaagccca  cggtgctac  gaaccgatt  840
ctgtgaagt  tgccaacaa  cccagccag  agtccagcc  ggccctgct  tcccagctc  900
accagtccc  taaccggcg  tacccaggt  cacttcacc  ccaggctca  aggttcagg  960
tggacaatt  gcttaatat  gcctatggc  taaagagac  gatgtctgg  ccagtcccc  1020
cttctgctt  ttcccccag  ttctcccca  ttaccattg  tggaatgac  agccttgtg  1080
gaatgaaca  ccctggtca  acaggaact  ggtggtgca  ctttgtcta  aacctgtcc  1140
ccgattccg  tgagagtgt  ctctggcag  tctttggcc  ctttggagc  gtgaacaac  1200
taaaggtga  tcgtgactt  aacaccaac  agtgcaagg  attcggctt  gtcaccatg  1260
ccaactatg  tgaggcggc  atggccatc  ccagcctca  cgggtaccg  ctgggagac  1320
gagtgttgc  agtttcctt  aaaaccaac  aagcccaca  gtcctgaat  tcccattct  1380
acttactaa  atatatata  aaatatata  gaacaaaac  cacgcgcgc  cacacacac  1440
tacacgaaa  agagagaaa  aaacttttc  aggcttata  tcaaccatg  actttataa  1500
ccagtgttg  ctaagtatt  aaacattgg  ttatcctga  gtgtaccag  aaaggattt  1560
ataatgctt  gaaaaaaaa  aaaaaaaaa  a  1591



<210> 7896
<211> 380
<212> PRT
<213> Homo sapiens
<308> P26378
<400> 7896

Met Val Met Ile Ile Ser Thr Met Glu Pro Gln Val Ser Asn Gly Pro 
  1               5                  10                  15
Thr Ser Asn Thr Ser Asn Gly Pro Ser Ser Asn Asn Arg Asn Cys Pro 
             20                  25                  30
Ser Pro Met Gln Thr Gly Ala Thr Thr Asp Asp Ser Lys Thr Asn Leu 
         35                  40                  45
Ile Val Asn Tyr Leu Pro Gln Asn Met Thr Gln Glu Glu Phe Arg Ser 
     50                  55                  60
Leu Phe Gly Ser Ile Gly Glu Ile Glu Ser Cys Lys Leu Val Arg Asp 
 65                  70                  75                  80
Lys Ile Thr Gly Gln Ser Leu Gly Tyr Gly Phe Val Asn Tyr Ile Asp 
                 85                  90                  95
Pro Lys Asp Ala Glu Lys Ala Ile Asn Thr Leu Asn Gly Leu Arg Leu 
             100                105                110
Gln Thr Lys Thr Ile Lys Val Ser Tyr Ala Arg Pro Ser Ser Ala Ser 
         115                120                125
Ile Arg Asp Ala Asn Leu Tyr Val Ser Gly Leu Pro Lys Thr Met Thr 
     130                135                140
Gln Lys Glu Leu Glu Gln Leu Phe Ser Gln Tyr Gly Arg Ile Ile Thr 
 145                150                155                160
Ser Arg Ile Leu Val Asp Gln Val Thr Gly Val Ser Arg Gly Val Gly 
                 165                170                175
Phe Ile Arg Phe Asp Lys Arg Ile Glu Ala Glu Glu Ala Ile Lys Gly 
             180                185                190
Leu Asn Gly Gln Lys Pro Ser Gly Ala Thr Glu Pro Ile Thr Val Lys 
         195                200                205
Phe Ala Asn Asn Pro Ser Gln Lys Ser Ser Gln Ala Leu Leu Ser Gln 
     210                215                220
Leu Tyr Gln Ser Pro Asn Arg Arg Tyr Pro Gly Pro Leu His His Gln 
 225                230                235                240
Ala Gln Arg Phe Arg Leu Asp Asn Leu Leu Asn Met Ala Tyr Gly Val 
                 245                250                255
Lys Arg Leu Met Ser Gly Pro Val Pro Pro Ser Ala Cys Ser Pro Arg 
             260                265                270
Phe Ser Pro Ile Thr Ile Asp Gly Met Thr Ser Leu Val Gly Met Asn 
         275                280                285
Ile Pro Gly His Thr Gly Thr Gly Trp Cys Ile Phe Val Tyr Asn Leu 
     290                295                300
Ser Pro Asp Ser Asp Glu Ser Val Leu Trp Gln Leu Phe Gly Pro Phe 
 305                310                315                320
Gly Ala Val Asn Asn Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys 
                 325                330                335
Cys Lys Gly Phe Gly Phe Val Thr Met Thr Asn Tyr Asp Glu Ala Ala 
             340                345                350
Met Ala Ile Ala Ser Leu Asn Gly Tyr Arg Leu Gly Asp Arg Val Leu 
         355                360                365
Gln Val Ser Phe Lys Thr Asn Lys Ala His Lys Ser 
     370                375                380



<210> 7897
<211> 1444
<212> DNA
<213> Rattus norvegicus
<308> S83320
<400> 7897

agcagctct  taagaaggg  atgtcggct  ttacataac  ttcctctct  cttttgaca  60
actgtgtga  ggtccatct  ctgatcaca  atggagtgg  atggcttga  gatgataat  120
agcaccatg  agcctcagg  gtcaaatgg  ccgacatcc  atacaagca  tggaccctc  180
agcaacaac  gaaactgtc  ttctcccat  cagacaggc  ccgccacag  cgacagcaa  240
accaacctc  tcgtcaact  tttacccca  aatatgacc  aagaggaat  caggagtct  300
tttgggagc  ttggtgaaa  cgaatcctg  aaactcgtg  gagacaaaa  tacaggaca  360
agtttaggg  atggatttg  taactatat  gatccaaag  atgcagaga  agccatcaa  420
actttaaat  gactcagac  ccagaccaa  accataaag  tgtcgtacg  ccgtccgag  480
tcggcctca  tcagggatg  taacctgta  gttagtggc  ttcccaaga  catgaccca  540
aaggagctg  agcagcttt  ctctcagta  ggtcgcatc  tcacctcac  catcctggt  600
gatcaagtc  caggagtct  tagaggggt  ggattcatc  gctttgata  gaggattga  660
gcagaagaa  ccatcaaag  gctgaatgg  cagaagccc  gcggtgcta  agaaccgat  720
actgtgaag  ttgccaaca  ccccagcca  aagtccagc  aggccctgc  ctcccagct  780
taccagtcc  ccaacaggc  ataccctgg  cctctccac  accaggctc  aagattcag  840
ctggacaat  tgcttaata  ggcctatgg  gtaaagaga  tgatgtctg  accagtccc  900
ccttctgct  gtcccccca  gttctcccc  atcaccatt  acgggatga  aagtcttgt  960
ggaatgaac  tccctggtc  cacagggac  ggctggtgc  tcttcgtct  taacctgtc  1020
cctgattct  atgagagtg  cctctggca  ctctttggc  cctttggcg  agtgaacaa  1080
gtcaaggtc  tccgtgact  caacaccaa  aaatgcaag  gattcggct  tgtcaccat  1140
accaactac  atgaggcag  catggccat  gccagcctc  atggttacc  cctgggaga  1200
agagtgttg  aagtttcct  taaaaccaa  aaagcccac  agtcctgaa  ttctcaccc  1260
tacttatta  aaaatatat  taaatatat  cgaacaaaa  atgcgtgca  acacataca  1320
aaaagagag  gacaaactt  ccaaggctt  tattcaacc  tggacttta  aagcccgcg  1380
tgcctaagt  ttaaaacat  ggattatcc  gaggtgtac  aggaaagga  tttataatg  1440
ttag  1444



<210> 7898
<211> 373
<212> PRT
<213> Rattus norvegicus
<308> AAB50733
<400> 7898

Met Glu Pro Gln Val Ser Asn Gly Pro Thr Ser Asn Thr Ser Asn Gly 
  1               5                  10                  15
Pro Ser Ser Asn Asn Arg Asn Cys Pro Ser Pro Met Gln Thr Gly Ala 
             20                  25                  30
Ala Thr Asp Asp Ser Lys Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln 
         35                  40                  45
Asn Met Thr Gln Glu Glu Phe Arg Ser Leu Phe Gly Ser Ile Gly Glu 
     50                  55                  60
Ile Glu Ser Cys Lys Leu Val Arg Asp Lys Ile Thr Gly Gln Ser Leu 
 65                  70                  75                  80
Gly Tyr Gly Phe Val Asn Tyr Ile Asp Pro Lys Asp Ala Glu Lys Ala 
                 85                  90                  95
Ile Asn Thr Leu Asn Gly Leu Arg Leu Gln Thr Lys Thr Ile Lys Val 
             100                105                110
Ser Tyr Ala Arg Pro Ser Ser Ala Ser Ile Arg Asp Ala Asn Leu Tyr 
         115                120                125
Val Ser Gly Leu Pro Lys Thr Met Thr Gln Lys Glu Leu Glu Gln Leu 
     130                135                140
Phe Ser Gln Tyr Gly Arg Ile Ile Thr Ser Arg Ile Leu Val Asp Gln 
 145                150                155                160
Val Thr Gly Val Ser Arg Gly Val Gly Phe Ile Arg Phe Asp Lys Arg 
                 165                170                175
Ile Glu Ala Glu Glu Ala Ile Lys Gly Leu Asn Gly Gln Lys Pro Ser 
             180                185                190
Gly Ala Thr Glu Pro Ile Thr Val Lys Phe Ala Asn Asn Pro Ser Gln 
         195                200                205
Lys Ser Ser Gln Ala Leu Leu Ser Gln Leu Tyr Gln Ser Pro Asn Arg 
     210                215                220
Arg Tyr Pro Gly Pro Leu His His Gln Ala Gln Arg Phe Arg Leu Asp 
 225                230                235                240
Asn Leu Leu Asn Met Ala Tyr Gly Val Lys Arg Leu Met Ser Gly Pro 
                 245                250                255
Val Pro Pro Ser Ala Cys Pro Pro Arg Phe Ser Pro Ile Thr Ile Asp 
             260                265                270
Gly Met Thr Ser Leu Val Gly Met Asn Ile Pro Gly His Thr Gly Thr 
         275                280                285
Gly Trp Cys Ile Phe Val Tyr Asn Leu Ser Pro Asp Ser Asp Glu Ser 
     290                295                300
Val Leu Trp Gln Leu Phe Gly Pro Phe Gly Ala Val Asn Asn Val Lys 
 305                310                315                320
Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys Gly Phe Gly Phe Val 
                 325                330                335
Thr Met Thr Asn Tyr Asp Glu Ala Ala Met Ala Ile Ala Ser Leu Asn 
             340                345                350
Gly Tyr Arg Leu Gly Asp Arg Val Leu Gln Val Ser Phe Lys Thr Asn 
         355                360                365
Lys Ala His Lys Ser 
     370



<210> 7899
<211> 1591
<212> DNA
<213> Homo sapiens
<308> NM_021952
<400> 7899

tagaatcgg  ggtttcagc  cactgctcc  tttcttttt  ttctttctc  cccccgccc  60
cccccccaa  aataattga  ttgctttac  atcatccac  ctgtgtttt  tggatcttt  120
attatatat  acaatagta  tcattttaa  tatatattc  gaaatcttt  caaatttta  180
cagaagagt  gaagctctg  gagacccaa  atttgccaa  aagaatggt  atgataatt  240
gcaccatgg  gcctcaggt  tcaaatggt  cgacatcca  tacaagcaa  ggaccctcc  300
gcaacaaca  aaactgtcc  tctcccatg  aaacagggg  aaccacaga  gacagcaaa  360
ccaacctca  cgtcaacta  ttaccccag  atatgaccc  agaagaatt  aggagtctc  420
tcgggagca  tggtgaaat  gaatcctgc  aacttgtga  agacaaaat  acaggacag  480
gtttagggt  tggatttgt  aactatatt  atccaaagg  tgcagagaa  gccatcaac  540
ctttaaatg  actcagact  cagaccaaa  ccataaagg  ctcatatgc  cgtccgagc  600
ctgcctcaa  cagggatgc  aacctctat  ttagcggcc  tcccaaaac  atgacccag  660
aggaactgg  gcaactttt  tcgcaatac  gccgtatca  cacctcacg  atcctggtt  720
atcaagtca  aggagtgtc  agaggggtg  gattcatcc  ctttgataa  aggattgag  780
cagaagaag  catcaaagg  ctgaatggc  agaagccca  cggtgctac  gaaccgatt  840
ctgtgaagt  tgccaacaa  cccagccag  agtccagcc  ggccctgct  tcccagctc  900
accagtccc  taaccggcg  tacccaggt  cacttcacc  ccaggctca  aggttcagg  960
tggacaatt  gcttaatat  gcctatggc  taaagagac  gatgtctgg  ccagtcccc  1020
cttctgctt  ttcccccag  ttctcccca  ttaccattg  tggaatgac  agccttgtg  1080
gaatgaaca  ccctggtca  acaggaact  ggtggtgca  ctttgtcta  aacctgtcc  1140
ccgattccg  tgagagtgt  ctctggcag  tctttggcc  ctttggagc  gtgaacaac  1200
taaaggtga  tcgtgactt  aacaccaac  agtgcaagg  attcggctt  gtcaccatg  1260
ccaactatg  tgaggcggc  atggccatc  ccagcctca  cgggtaccg  ctgggagac  1320
gagtgttgc  agtttcctt  aaaaccaac  aagcccaca  gtcctgaat  tcccattct  1380
acttactaa  atatatata  aaatatata  gaacaaaac  cacgcgcgc  cacacacac  1440
tacacgaaa  agagagaaa  aaacttttc  aggcttata  tcaaccatg  actttataa  1500
ccagtgttg  ctaagtatt  aaacattgg  ttatcctga  gtgtaccag  aaaggattt  1560
ataatgctt  gaaaaaaaa  aaaaaaaaa  a  1591



<210> 7900
<211> 380
<212> PRT
<213> Homo sapiens
<308> P26378
<400> 7900

Met Val Met Ile Ile Ser Thr Met Glu Pro Gln Val Ser Asn Gly Pro 
  1               5                  10                  15
Thr Ser Asn Thr Ser Asn Gly Pro Ser Ser Asn Asn Arg Asn Cys Pro 
             20                  25                  30
Ser Pro Met Gln Thr Gly Ala Thr Thr Asp Asp Ser Lys Thr Asn Leu 
         35                  40                  45
Ile Val Asn Tyr Leu Pro Gln Asn Met Thr Gln Glu Glu Phe Arg Ser 
     50                  55                  60
Leu Phe Gly Ser Ile Gly Glu Ile Glu Ser Cys Lys Leu Val Arg Asp 
 65                  70                  75                  80
Lys Ile Thr Gly Gln Ser Leu Gly Tyr Gly Phe Val Asn Tyr Ile Asp 
                 85                  90                  95
Pro Lys Asp Ala Glu Lys Ala Ile Asn Thr Leu Asn Gly Leu Arg Leu 
             100                105                110
Gln Thr Lys Thr Ile Lys Val Ser Tyr Ala Arg Pro Ser Ser Ala Ser 
         115                120                125
Ile Arg Asp Ala Asn Leu Tyr Val Ser Gly Leu Pro Lys Thr Met Thr 
     130                135                140
Gln Lys Glu Leu Glu Gln Leu Phe Ser Gln Tyr Gly Arg Ile Ile Thr 
 145                150                155                160
Ser Arg Ile Leu Val Asp Gln Val Thr Gly Val Ser Arg Gly Val Gly 
                 165                170                175
Phe Ile Arg Phe Asp Lys Arg Ile Glu Ala Glu Glu Ala Ile Lys Gly 
             180                185                190
Leu Asn Gly Gln Lys Pro Ser Gly Ala Thr Glu Pro Ile Thr Val Lys 
         195                200                205
Phe Ala Asn Asn Pro Ser Gln Lys Ser Ser Gln Ala Leu Leu Ser Gln 
     210                215                220
Leu Tyr Gln Ser Pro Asn Arg Arg Tyr Pro Gly Pro Leu His His Gln 
 225                230                235                240
Ala Gln Arg Phe Arg Leu Asp Asn Leu Leu Asn Met Ala Tyr Gly Val 
                 245                250                255
Lys Arg Leu Met Ser Gly Pro Val Pro Pro Ser Ala Cys Ser Pro Arg 
             260                265                270
Phe Ser Pro Ile Thr Ile Asp Gly Met Thr Ser Leu Val Gly Met Asn 
         275                280                285
Ile Pro Gly His Thr Gly Thr Gly Trp Cys Ile Phe Val Tyr Asn Leu 
     290                295                300
Ser Pro Asp Ser Asp Glu Ser Val Leu Trp Gln Leu Phe Gly Pro Phe 
 305                310                315                320
Gly Ala Val Asn Asn Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys 
                 325                330                335
Cys Lys Gly Phe Gly Phe Val Thr Met Thr Asn Tyr Asp Glu Ala Ala 
             340                345                350
Met Ala Ile Ala Ser Leu Asn Gly Tyr Arg Leu Gly Asp Arg Val Leu 
         355                360                365
Gln Val Ser Phe Lys Thr Asn Lys Ala His Lys Ser 
     370                375                380



<210> 7901
<211> 1444
<212> DNA
<213> Rattus norvegicus
<308> S83320
<400> 7901

agcagctct  taagaaggg  atgtcggct  ttacataac  ttcctctct  cttttgaca  60
actgtgtga  ggtccatct  ctgatcaca  atggagtgg  atggcttga  gatgataat  120
agcaccatg  agcctcagg  gtcaaatgg  ccgacatcc  atacaagca  tggaccctc  180
agcaacaac  gaaactgtc  ttctcccat  cagacaggc  ccgccacag  cgacagcaa  240
accaacctc  tcgtcaact  tttacccca  aatatgacc  aagaggaat  caggagtct  300
tttgggagc  ttggtgaaa  cgaatcctg  aaactcgtg  gagacaaaa  tacaggaca  360
agtttaggg  atggatttg  taactatat  gatccaaag  atgcagaga  agccatcaa  420
actttaaat  gactcagac  ccagaccaa  accataaag  tgtcgtacg  ccgtccgag  480
tcggcctca  tcagggatg  taacctgta  gttagtggc  ttcccaaga  catgaccca  540
aaggagctg  agcagcttt  ctctcagta  ggtcgcatc  tcacctcac  catcctggt  600
gatcaagtc  caggagtct  tagaggggt  ggattcatc  gctttgata  gaggattga  660
gcagaagaa  ccatcaaag  gctgaatgg  cagaagccc  gcggtgcta  agaaccgat  720
actgtgaag  ttgccaaca  ccccagcca  aagtccagc  aggccctgc  ctcccagct  780
taccagtcc  ccaacaggc  ataccctgg  cctctccac  accaggctc  aagattcag  840
ctggacaat  tgcttaata  ggcctatgg  gtaaagaga  tgatgtctg  accagtccc  900
ccttctgct  gtcccccca  gttctcccc  atcaccatt  acgggatga  aagtcttgt  960
ggaatgaac  tccctggtc  cacagggac  ggctggtgc  tcttcgtct  taacctgtc  1020
cctgattct  atgagagtg  cctctggca  ctctttggc  cctttggcg  agtgaacaa  1080
gtcaaggtc  tccgtgact  caacaccaa  aaatgcaag  gattcggct  tgtcaccat  1140
accaactac  atgaggcag  catggccat  gccagcctc  atggttacc  cctgggaga  1200
agagtgttg  aagtttcct  taaaaccaa  aaagcccac  agtcctgaa  ttctcaccc  1260
tacttatta  aaaatatat  taaatatat  cgaacaaaa  atgcgtgca  acacataca  1320
aaaagagag  gacaaactt  ccaaggctt  tattcaacc  tggacttta  aagcccgcg  1380
tgcctaagt  ttaaaacat  ggattatcc  gaggtgtac  aggaaagga  tttataatg  1440
ttag  1444



<210> 7902
<211> 373
<212> PRT
<213> Rattus norvegicus
<308> AAB50733
<400> 7902

Met Glu Pro Gln Val Ser Asn Gly Pro Thr Ser Asn Thr Ser Asn Gly 
  1               5                  10                  15
Pro Ser Ser Asn Asn Arg Asn Cys Pro Ser Pro Met Gln Thr Gly Ala 
             20                  25                  30
Ala Thr Asp Asp Ser Lys Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln 
         35                  40                  45
Asn Met Thr Gln Glu Glu Phe Arg Ser Leu Phe Gly Ser Ile Gly Glu 
     50                  55                  60
Ile Glu Ser Cys Lys Leu Val Arg Asp Lys Ile Thr Gly Gln Ser Leu 
 65                  70                  75                  80
Gly Tyr Gly Phe Val Asn Tyr Ile Asp Pro Lys Asp Ala Glu Lys Ala 
                 85                  90                  95
Ile Asn Thr Leu Asn Gly Leu Arg Leu Gln Thr Lys Thr Ile Lys Val 
             100                105                110
Ser Tyr Ala Arg Pro Ser Ser Ala Ser Ile Arg Asp Ala Asn Leu Tyr 
         115                120                125
Val Ser Gly Leu Pro Lys Thr Met Thr Gln Lys Glu Leu Glu Gln Leu 
     130                135                140
Phe Ser Gln Tyr Gly Arg Ile Ile Thr Ser Arg Ile Leu Val Asp Gln 
 145                150                155                160
Val Thr Gly Val Ser Arg Gly Val Gly Phe Ile Arg Phe Asp Lys Arg 
                 165                170                175
Ile Glu Ala Glu Glu Ala Ile Lys Gly Leu Asn Gly Gln Lys Pro Ser 
             180                185                190
Gly Ala Thr Glu Pro Ile Thr Val Lys Phe Ala Asn Asn Pro Ser Gln 
         195                200                205
Lys Ser Ser Gln Ala Leu Leu Ser Gln Leu Tyr Gln Ser Pro Asn Arg 
     210                215                220
Arg Tyr Pro Gly Pro Leu His His Gln Ala Gln Arg Phe Arg Leu Asp 
 225                230                235                240
Asn Leu Leu Asn Met Ala Tyr Gly Val Lys Arg Leu Met Ser Gly Pro 
                 245                250                255
Val Pro Pro Ser Ala Cys Pro Pro Arg Phe Ser Pro Ile Thr Ile Asp 
             260                265                270
Gly Met Thr Ser Leu Val Gly Met Asn Ile Pro Gly His Thr Gly Thr 
         275                280                285
Gly Trp Cys Ile Phe Val Tyr Asn Leu Ser Pro Asp Ser Asp Glu Ser 
     290                295                300
Val Leu Trp Gln Leu Phe Gly Pro Phe Gly Ala Val Asn Asn Val Lys 
 305                310                315                320
Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys Gly Phe Gly Phe Val 
                 325                330                335
Thr Met Thr Asn Tyr Asp Glu Ala Ala Met Ala Ile Ala Ser Leu Asn 
             340                345                350
Gly Tyr Arg Leu Gly Asp Arg Val Leu Gln Val Ser Phe Lys Thr Asn 
         355                360                365
Lys Ala His Lys Ser 
     370



<210> 7903
<211> 1591
<212> DNA
<213> Homo sapiens
<308> NM_021952
<400> 7903

tagaatcgg  ggtttcagc  cactgctcc  tttcttttt  ttctttctc  cccccgccc  60
cccccccaa  aataattga  ttgctttac  atcatccac  ctgtgtttt  tggatcttt  120
attatatat  acaatagta  tcattttaa  tatatattc  gaaatcttt  caaatttta  180
cagaagagt  gaagctctg  gagacccaa  atttgccaa  aagaatggt  atgataatt  240
gcaccatgg  gcctcaggt  tcaaatggt  cgacatcca  tacaagcaa  ggaccctcc  300
gcaacaaca  aaactgtcc  tctcccatg  aaacagggg  aaccacaga  gacagcaaa  360
ccaacctca  cgtcaacta  ttaccccag  atatgaccc  agaagaatt  aggagtctc  420
tcgggagca  tggtgaaat  gaatcctgc  aacttgtga  agacaaaat  acaggacag  480
gtttagggt  tggatttgt  aactatatt  atccaaagg  tgcagagaa  gccatcaac  540
ctttaaatg  actcagact  cagaccaaa  ccataaagg  ctcatatgc  cgtccgagc  600
ctgcctcaa  cagggatgc  aacctctat  ttagcggcc  tcccaaaac  atgacccag  660
aggaactgg  gcaactttt  tcgcaatac  gccgtatca  cacctcacg  atcctggtt  720
atcaagtca  aggagtgtc  agaggggtg  gattcatcc  ctttgataa  aggattgag  780
cagaagaag  catcaaagg  ctgaatggc  agaagccca  cggtgctac  gaaccgatt  840
ctgtgaagt  tgccaacaa  cccagccag  agtccagcc  ggccctgct  tcccagctc  900
accagtccc  taaccggcg  tacccaggt  cacttcacc  ccaggctca  aggttcagg  960
tggacaatt  gcttaatat  gcctatggc  taaagagac  gatgtctgg  ccagtcccc  1020
cttctgctt  ttcccccag  ttctcccca  ttaccattg  tggaatgac  agccttgtg  1080
gaatgaaca  ccctggtca  acaggaact  ggtggtgca  ctttgtcta  aacctgtcc  1140
ccgattccg  tgagagtgt  ctctggcag  tctttggcc  ctttggagc  gtgaacaac  1200
taaaggtga  tcgtgactt  aacaccaac  agtgcaagg  attcggctt  gtcaccatg  1260
ccaactatg  tgaggcggc  atggccatc  ccagcctca  cgggtaccg  ctgggagac  1320
gagtgttgc  agtttcctt  aaaaccaac  aagcccaca  gtcctgaat  tcccattct  1380
acttactaa  atatatata  aaatatata  gaacaaaac  cacgcgcgc  cacacacac  1440
tacacgaaa  agagagaaa  aaacttttc  aggcttata  tcaaccatg  actttataa  1500
ccagtgttg  ctaagtatt  aaacattgg  ttatcctga  gtgtaccag  aaaggattt  1560
ataatgctt  gaaaaaaaa  aaaaaaaaa  a  1591



<210> 7904
<211> 380
<212> PRT
<213> Homo sapiens
<308> P26378
<400> 7904

Met Val Met Ile Ile Ser Thr Met Glu Pro Gln Val Ser Asn Gly Pro 
  1               5                  10                  15
Thr Ser Asn Thr Ser Asn Gly Pro Ser Ser Asn Asn Arg Asn Cys Pro 
             20                  25                  30
Ser Pro Met Gln Thr Gly Ala Thr Thr Asp Asp Ser Lys Thr Asn Leu 
         35                  40                  45
Ile Val Asn Tyr Leu Pro Gln Asn Met Thr Gln Glu Glu Phe Arg Ser 
     50                  55                  60
Leu Phe Gly Ser Ile Gly Glu Ile Glu Ser Cys Lys Leu Val Arg Asp 
 65                  70                  75                  80
Lys Ile Thr Gly Gln Ser Leu Gly Tyr Gly Phe Val Asn Tyr Ile Asp 
                 85                  90                  95
Pro Lys Asp Ala Glu Lys Ala Ile Asn Thr Leu Asn Gly Leu Arg Leu 
             100                105                110
Gln Thr Lys Thr Ile Lys Val Ser Tyr Ala Arg Pro Ser Ser Ala Ser 
         115                120                125
Ile Arg Asp Ala Asn Leu Tyr Val Ser Gly Leu Pro Lys Thr Met Thr 
     130                135                140
Gln Lys Glu Leu Glu Gln Leu Phe Ser Gln Tyr Gly Arg Ile Ile Thr 
 145                150                155                160
Ser Arg Ile Leu Val Asp Gln Val Thr Gly Val Ser Arg Gly Val Gly 
                 165                170                175
Phe Ile Arg Phe Asp Lys Arg Ile Glu Ala Glu Glu Ala Ile Lys Gly 
             180                185                190
Leu Asn Gly Gln Lys Pro Ser Gly Ala Thr Glu Pro Ile Thr Val Lys 
         195                200                205
Phe Ala Asn Asn Pro Ser Gln Lys Ser Ser Gln Ala Leu Leu Ser Gln 
     210                215                220
Leu Tyr Gln Ser Pro Asn Arg Arg Tyr Pro Gly Pro Leu His His Gln 
 225                230                235                240
Ala Gln Arg Phe Arg Leu Asp Asn Leu Leu Asn Met Ala Tyr Gly Val 
                 245                250                255
Lys Arg Leu Met Ser Gly Pro Val Pro Pro Ser Ala Cys Ser Pro Arg 
             260                265                270
Phe Ser Pro Ile Thr Ile Asp Gly Met Thr Ser Leu Val Gly Met Asn 
         275                280                285
Ile Pro Gly His Thr Gly Thr Gly Trp Cys Ile Phe Val Tyr Asn Leu 
     290                295                300
Ser Pro Asp Ser Asp Glu Ser Val Leu Trp Gln Leu Phe Gly Pro Phe 
 305                310                315                320
Gly Ala Val Asn Asn Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys 
                 325                330                335
Cys Lys Gly Phe Gly Phe Val Thr Met Thr Asn Tyr Asp Glu Ala Ala 
             340                345                350
Met Ala Ile Ala Ser Leu Asn Gly Tyr Arg Leu Gly Asp Arg Val Leu 
         355                360                365
Gln Val Ser Phe Lys Thr Asn Lys Ala His Lys Ser 
     370                375                380



<210> 7905
<211> 4541
<212> DNA
<213> Rattus norvegicus
<308> S83358
<400> 7905

taggaaccc  gatccatgg  gtctcatga  tagctggtt  tatcctgtt  attggctta  60
tctggccag  acggtctgt  tttcagatt  cggaagcag  agattcagt  actgagagg  120
caccgtgga  ctgctggaa  ctgttacag  aggagcacc  ctcaaaccg  gcttcaggc  180
ctgaaaaaa  ggagcacag  ggaagctta  tcttgcttt  gatccaagc  aatgctgtc  240
gagcgatga  ctgggactt  gtgtgcgga  tcctggctt  atcttgata  gattgggtg  300
atgttgttg  aacgggcag  ccaagaggc  tgagatcta  aggtgccgt  tatatggag  360
aaagcggct  tagtccatt  ccagtgtgt  gggctaaag  atatgacag  tacctagca  420
ctagcaaaa  aatggcagc  gcttatctt  acccaaact  gaatcacac  ccaagttcg  480
gtactaaga  tcacctggg  actggcacg  aacggtccc  tggtgcaat  gaacgagta  540
taaaggtct  tcattattt  gaaagcagt  atgagccaa  cacctgggc  agtattatc  600
ggcatggag  cgctactga  gtcagggga  tcattcaga  gatagtgga  agtcacaaa  660
taaagcacg  ggcctgcta  ggatttcgc  tcagtcacc  gcgatcgga  gaggtgcac  720
ggctgcatg  ggacatggg  gtctccagt  tgagggaga  atacgaact  gcccaccca  780
cagaggagt  gaaatatga  ttgagaatt  gttatttgc  aaaaggatt  ctaaaccag  840
ttactgaag  taagccaac  ttgaatttc  tctatcaac  ggtgaagag  gactacatg  900
tagaaatag  tgatcaagt  gaccaagac  tagctttga  gttgggttg  ttggaaatt  960
ggcgatcct  ctgggagat  aggggcaac  ccctagaga  gaagtccaa  tatgaagtg  1020
tagagaaag  tgttggttt  aagcgattt  ttcccaaga  tttactgga  tccgtgaag  1080
ccaaaacac  aagaaagct  atccagcaa  cattcaggc  gtttgccaa  cttaataga  1140
aagaaagca  cctgaaatt  tttgagatt  tctctccag  gtacagatt  gacaaagag  1200
gcttcaagt  tgcccttgg  tcaagttgg  ttatttctg  ggaactggc  atcggccca  1260
aagaaggga  cagttacct  acagacaag  gctgcaatc  cacacacct  gcggacttc  1320
accaagtgc  gaccatcca  tactcaaac  gtgaagaca  agacaggaa  ggaatgcta  1380
aactcaaaa  cgctggtgc  cctgagcct  tgacagtga  ggccccatc  ctaaccatt  1440
cagagaaca  ggctgacct  atcgatgga  actgccggc  ggtgaacgg  gccacgcag  1500
ccttcatca  cagacccca  aaagaaggt  aacgggcat  gccatcaat  ccaaagttg  1560
ccaacaatg  aaagcaagg  atgcggaca  atgcagtct  tgtgtcaga  acagatgac  1620
atgccgaga  catcgatga  gaagacaca  acaccatgc  ctcaaccag  gattatgag  1680
ttcagagag  aaggataga  cttggacgc  gtattggag  aggccagtt  ggagatgta  1740
atcaaggcg  gtacctgag  ccagagaat  cagctttgg  tgttgcaat  aaaacatgt  1800
aaaactgta  ttcggacag  gtgagagag  agttccttc  agaagcctt  acaatgcgc  1860
agtttgacc  tcctcacat  gtgaagctg  ttggagtca  tacagagaa  ccagtttgg  1920
taatcatgg  gttgtgcac  cttggagag  tgaggtcat  tttgcaagt  aggaaatac  1980
gcttggatc  agcatcttt  atcttatat  cctatcagc  tagtacagc  ctcgcgtat  2040
tggagagca  aagatttgt  cacagggac  ttgctgcac  gaatgttct  gtgtcttca  2100
atgattgtg  aaaattagg  gactttgga  tatctcgat  tatggaaga  agtacttac  2160
ataaagctt  caaaggaaa  ttacctatt  aatggatgg  tccagagtc  atcaatttt  2220
gacgtttta  ctcagctag  gacgtgtgg  tgtttggtg  gtgtatgtg  gagatactg  2280
tgcatggcg  gaagccttt  caaggagtg  agaacaatg  tgtgatcgg  cgaattgaa  2340
atggggaaa  attaccaat  cctccaaat  gtcctccca  cctctacag  cttatgacg  2400
aatgttggg  ctatgaccc  agcagacgg  ccaggttta  tgaactaaa  gctcagctc  2460
gcacaatcc  ggaggaaga  aaggtgcag  aagaagaac  gatgaggat  gaatccaga  2520
gacaggcaa  agtgtcctg  gactctgga  ggtctgatg  agcaccacc  aagcccagc  2580
gacctggtt  tcctagccc  aggtccagt  aaggatttt  tcccagccc  cagcacatg  2640
tccagacca  tcactatca  atctctggc  acccaggtt  ccatggaat  ccagccatg  2700
ctggcagca  ttacccagg  caggcatct  ttctggacc  gacagaatt  tggaatcac  2760
gacctcagg  gatgtccat  tggcagccc  gtgtggagg  ctcagcagc  ttagatctt  2820
gagggatgg  acaggtgct  cctcctcac  tgatggaag  gcggctaat  cgacagcag  2880
aggaaatgg  ggaagacca  cgctggctg  aaaaggaag  gcgattcct  aaacctgat  2940
tgaggctct  tcgaggcag  atcgacagg  aggacggga  ttttcaggg  ccgactgga  3000
accaacaca  ctatcagcc  gtgggaaaa  cagatcctg  agctccacc  aagaaacca  3060
ctcgccctg  agcacctgg  cacctaagc  acttgtcca  catcagcag  cctgcagaa  3120
gctacaatg  gggtgtcaa  ccgtggagg  ttcagcccc  ggaaatcag  ccccctccc  3180
ctgccaacc  tgaccgatc  aatgacaag  tatatgaaa  tgtgacggg  ctagtgaag  3240
ctgtcattg  gatgtccag  aaaatccaa  cagctcctc  agaagagta  gtccctatg  3300
tgaaggaag  tggcctggc  ctgcggacc  tactggcaa  tgtggatga  accattccc  3360
tccttccag  cagcaccca  cgagagatc  agatggcac  gaagctgct  aactccgac  3420
tgggtgagc  catcagcaa  atgaagctg  cgcagcagt  tgtcatgac  agccttcag  3480
aggagtaca  gaagcagat  ctgacagct  ctcacgccc  ggctgtgga  gccaagaat  3540
tacttgatg  tattgatca  gcgagactg  aaatgctag  gcagacacg  ccacactga  3600
ccactggcc  ttgaacatg  ctttctgcc  tttgggaga  cttctctag  attccacca  3660
cagcgagga  gtaaccttg  cctcggtcg  ccgcactca  agctccaac  gatgacagc  3720
agctgaaag  ctctcttgt  taagtttaa  tacttatac  tggttttga  tctgttatt  3780
ttctaaata  tgttcagaa  actctggat  caaaatgtg  catttttct  agaatgaag  3840
ttgtacatt  agaagcttt  aaaatatac  tggtgttca  attgggatg  atgttccta  3900
aagtggtaa  tcatactga  catgacttc  aattggaag  gaagtgtct  aggagggag  3960
gctcccaag  cactgagac  ggctatcct  cctgccaga  ttcctgtcc  gactgaatt  4020
caatatgct  atctcatta  agagaagtg  ataaaagct  tattttgaa  aatgagtgg  4080
ttcaaaaga  aacttctgc  ctccctgtc  tcaccttct  tcctgtgga  cctgaagca  4140
tgggttgca  actatctct  gaactgaca  aaacttgtc  ttcctcctc  gaattctgt  4200
ccagttttg  accagagca  tcccaactg  atcaagaag  tccaggacc  tccctgttc  4260
ccattttta  ataatttat  agaatgatt  aagccatgt  gactcttac  gccactgag  4320
taactgatc  catgcgtct  tcttcccag  gaggatccc  cagacaaac  gggatgtgg  4380
tttctttag  tgtccagtt  ttacaccat  cattctgtt  ggtggtttt  agagcatac  4440
ttcccttta  tttgttggg  atataaatt  ttctcagga  gaatataat  aattgtaca  4500
ttactctga  ctattaaaa  ggagctcgt  caaaaaaaa  a  4541



<210> 7906
<211> 1055
<212> PRT
<213> Rattus norvegicus
<308> AAB72203
<400> 7906

Met Ala Ala Ala Tyr Leu Asp Pro Asn Leu Asn His Thr Pro Ser Ser 
  1               5                  10                  15
Ser Thr Lys Thr His Leu Gly Thr Gly Thr Glu Arg Ser Pro Gly Ala 
             20                  25                  30
Met Glu Arg Val Leu Lys Val Phe His Tyr Phe Glu Ser Ser Asn Glu 
         35                  40                  45
Pro Thr Thr Trp Ala Ser Ile Ile Arg His Gly Asp Ala Thr Asp Val 
     50                  55                  60
Arg Gly Ile Ile Gln Lys Ile Val Asp Ser His Lys Val Lys His Val 
 65                  70                  75                  80
Ala Cys Tyr Gly Phe Arg Leu Ser His Leu Arg Ser Glu Glu Val His 
                 85                  90                  95
Trp Leu His Val Asp Met Gly Val Ser Ser Val Arg Glu Lys Tyr Glu 
             100                105                110
Leu Ala His Pro Pro Glu Glu Trp Lys Tyr Glu Leu Arg Ile Arg Tyr 
         115                120                125
Leu Pro Lys Gly Phe Leu Asn Gln Phe Thr Glu Asp Lys Pro Thr Leu 
     130                135                140
Asn Phe Phe Tyr Gln Gln Val Lys Ser Asp Tyr Met Leu Glu Ile Ala 
 145                150                155                160
Asp Gln Val Asp Gln Asp Ile Ala Leu Lys Leu Gly Cys Leu Glu Ile 
                 165                170                175
Arg Arg Ser Tyr Trp Glu Met Arg Gly Asn Ala Leu Glu Lys Lys Ser 
             180                185                190
Asn Tyr Glu Val Leu Glu Lys Asp Val Gly Leu Lys Arg Phe Phe Pro 
         195                200                205
Lys Ser Leu Leu Asp Ser Val Lys Ala Lys Thr Leu Arg Lys Leu Ile 
     210                215                220
Gln Gln Thr Phe Arg Gln Phe Ala Asn Leu Asn Arg Glu Glu Ser Ile 
 225                230                235                240
Leu Lys Phe Phe Glu Ile Leu Ser Pro Val Tyr Arg Phe Asp Lys Glu 
                 245                250                255
Cys Phe Lys Cys Ala Leu Gly Ser Ser Trp Ile Ile Ser Val Glu Leu 
             260                265                270
Ala Ile Gly Pro Glu Glu Gly Ile Ser Tyr Leu Thr Asp Lys Gly Cys 
         275                280                285
Asn Pro Thr His Leu Ala Asp Phe Asn Gln Val Gln Thr Ile Gln Tyr 
     290                295                300
Ser Asn Ser Glu Asp Lys Asp Arg Lys Gly Met Leu Gln Leu Lys Ile 
 305                310                315                320
Ala Gly Ala Pro Glu Pro Leu Thr Val Thr Ala Pro Ser Leu Thr Ile 
                 325                330                335
Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys Arg Leu Val Asn 
             340                345                350
Gly Ala Thr Gln Ser Phe Ile Ile Arg Pro Gln Lys Glu Gly Glu Arg 
         355                360                365
Ala Leu Pro Ser Ile Pro Lys Leu Ala Asn Asn Glu Lys Gln Gly Met 
     370                375                380
Arg Thr His Ala Val Ser Val Ser Glu Thr Asp Asp Tyr Ala Glu Ile 
 385                390                395                400
Ile Asp Glu Glu Asp Thr Tyr Thr Met Pro Ser Thr Arg Asp Tyr Glu 
                 405                410                415
Ile Gln Arg Glu Arg Ile Glu Leu Gly Arg Cys Ile Gly Glu Gly Gln 
             420                425                430
Phe Gly Asp Val His Gln Gly Val Tyr Leu Ser Pro Glu Asn Pro Ala 
         435                440                445
Leu Ala Val Ala Ile Lys Thr Cys Lys Asn Cys Thr Ser Asp Ser Val 
     450                455                460
Arg Glu Lys Phe Leu Gln Glu Ala Leu Thr Met Arg Gln Phe Asp His 
 465                470                475                480
Pro His Ile Val Lys Leu Ile Gly Val Ile Thr Glu Asn Pro Val Trp 
                 485                490                495
Ile Ile Met Glu Leu Cys Thr Leu Gly Glu Leu Arg Ser Phe Leu Gln 
             500                505                510
Val Arg Lys Tyr Ser Leu Asp Leu Ala Ser Leu Ile Leu Tyr Ala Tyr 
         515                520                525
Gln Leu Ser Thr Ala Leu Ala Tyr Leu Glu Ser Lys Arg Phe Val His 
     530                535                540
Arg Asp Ile Ala Ala Arg Asn Val Leu Val Ser Ser Asn Asp Cys Val 
 545                550                555                560
Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Met Glu Asp Ser Thr Tyr 
                 565                570                575
Tyr Lys Ala Ser Lys Gly Lys Leu Pro Ile Lys Trp Met Ala Pro Glu 
             580                585                590
Ser Ile Asn Phe Arg Arg Phe Thr Ser Ala Ser Asp Val Trp Met Phe 
         595                600                605
Gly Val Cys Met Trp Glu Ile Leu Met His Gly Val Lys Pro Phe Gln 
     610                615                620
Gly Val Lys Asn Asn Asp Val Ile Gly Arg Ile Glu Asn Gly Glu Arg 
 625                630                635                640
Leu Pro Met Pro Pro Asn Cys Pro Pro Thr Leu Tyr Ser Leu Met Thr 
                 645                650                655
Lys Cys Trp Ala Tyr Asp Pro Ser Arg Arg Pro Arg Phe Thr Glu Leu 
             660                665                670
Lys Ala Gln Leu Ser Thr Ile Leu Glu Glu Glu Lys Val Gln Gln Glu 
         675                680                685
Glu Arg Met Arg Met Glu Ser Arg Arg Gln Ala Thr Val Ser Trp Asp 
     690                695                700
Ser Gly Gly Ser Asp Glu Ala Pro Pro Lys Pro Ser Arg Pro Gly Tyr 
 705                710                715                720
Pro Ser Pro Arg Ser Ser Glu Gly Phe Tyr Pro Ser Pro Gln His Met 
                 725                730                735
Val Gln Thr Asn His Tyr Gln Ile Ser Gly Tyr Pro Gly Ser His Gly 
             740                745                750
Ile Pro Ala Met Ala Gly Ser Ile Tyr Pro Gly Gln Ala Ser Leu Leu 
         755                760                765
Asp Gln Thr Glu Leu Trp Asn His Arg Pro Gln Glu Met Ser Met Trp 
     770                775                780
Gln Pro Ser Val Glu Asp Ser Ala Ala Leu Asp Leu Arg Gly Met Gly 
 785                790                795                800
Gln Val Leu Pro Pro His Leu Met Glu Glu Arg Leu Ile Arg Gln Gln 
                 805                810                815
Gln Glu Met Glu Glu Asp Gln Arg Trp Leu Glu Lys Glu Glu Arg Phe 
             820                825                830
Leu Lys Pro Asp Val Arg Leu Ser Arg Gly Ser Ile Asp Arg Glu Asp 
         835                840                845
Gly Ser Phe Gln Gly Pro Thr Gly Asn Gln His Ile Tyr Gln Pro Val 
     850                855                860
Gly Lys Pro Asp Pro Ala Ala Pro Pro Lys Lys Pro Pro Arg Pro Gly 
 865                870                875                880
Ala Pro Gly His Leu Ser Asn Leu Ser Ser Ile Ser Ser Pro Ala Glu 
                 885                890                895
Ser Tyr Asn Glu Gly Val Lys Pro Trp Arg Leu Gln Pro Gln Glu Ile 
             900                905                910
Ser Pro Pro Pro Thr Ala Asn Leu Asp Arg Ser Asn Asp Lys Val Tyr 
         915                920                925
Glu Asn Val Thr Gly Leu Val Lys Ala Val Ile Glu Met Ser Ser Lys 
     930                935                940
Ile Gln Pro Ala Pro Pro Glu Glu Tyr Val Pro Met Val Lys Glu Val 
 945                950                955                960
Gly Leu Ala Leu Arg Thr Leu Leu Ala Thr Val Asp Glu Thr Ile Pro 
                 965                970                975
Ile Leu Pro Ala Ser Thr His Arg Glu Ile Glu Met Ala Gln Lys Leu 
             980                985                990
Leu Asn Ser Asp Leu Gly Glu Leu Ile Ser Lys Met Lys Leu Ala Gln 
         995                1000                1005
Gln Tyr Val Met Thr Ser Leu Gln Gln Glu Tyr Lys Lys Gln Met Leu 
     1010                1015                1020
Thr Ala Ala His Ala Leu Ala Val Asp Ala Lys Asn Leu Leu Asp Val 
 1025                1030                1035                1040
Ile Asp Gln Ala Arg Leu Lys Met Leu Gly Gln Thr Arg Pro His 
                 1045                1050                1055



<210> 7907
<211> 3791
<212> DNA
<213> Homo sapiens
<308> L13616
<400> 7907

cgaccactg  gagcccgcg  cgtgaggcg  cgggaggaa  cgcggctgc  gtcgcccag  60
gccgccccg  cgtcgtctg  cttcgcttc  cggcgccga  ccgcggtcc  agcagaact  120
gggctccct  gcatcttcc  gttacaaat  cagtgcctt  tgcagtttc  ccagagctc  180
tcaagaata  cggaaggga  aatatgaca  atacctagc  tctagcaaa  taatggcag  240
tgcttacct  gaccccaac  tgaatcaca  accaaattc  agtactaag  ctcacctgg  300
tactggtat  gaacgttct  ctggtgcaa  ggagcgagt  ttaaaggtc  ttcattatt  360
tgaaagcaa  agtgagcca  ccacctggg  cagtattat  aggcatgga  atgctactg  420
tgtcagggg  atcattcag  agatagtgg  cagtcacaa  gtaaagcat  tggcctgct  480
tggattccg  ctcagtcac  tgcggtcag  ggaggttca  tggcttcac  tggatatgg  540
cgtctccag  gtgagggag  agtatgagc  tgctcaccc  ccagaggag  ggaaatatg  600
attgagaat  cgttatttg  caaaaggat  tctaaacca  tttactgaa  ataagccaa  660
tttgaattt  ttctatcaa  aggtgaaga  cgattatat  ttagagata  ctgatcaag  720
ggaccagga  attgctttg  agttgggtt  tctagaaat  cggcgatca  actgggaga  780
gcggggcaa  gcactagaa  agaagtcta  ctatgaagt  ttagaaaaa  atgttggtt  840
aaagcgatt  tttcctaag  gtttactgg  ttctgtcaa  gccaaaaca  taagaaaac  900
gatccaaca  acatttaga  aatttgcca  ccttaatag  gaagaaagt  ttctgaaat  960
ctttgagat  ctgtctcca  tctacagat  tgataagga  tgcttcaag  gtgctcttg  1020
ttcaagctg  attatttca  tggaactgg  aatcggccc  gaagaagga  tcagttacc  1080
aacggacaa  ggctgcaat  ccacacatc  tgctgactt  actcaagtg  aaaccattc  1140
gtattcaaa  agtgaagac  aggacagaa  aggaatgct  caactaaaa  tagcaggtg  1200
acccgagcc  ctgacagtg  cggcaccat  cctaaccat  gcggagaat  tggctgacc  1260
aatagatgg  tactgccgg  tggtgaatg  aacctcgca  tcatttatc  tcagacctc  1320
gaaagaagg  gaacgggct  tgccatcaa  accaaagtt  gccaacagc  aaaagcaag  1380
catgcggac  cacgccgtc  ctgtgtcag  aacagatga  tatgctgag  ttatagatg  1440
agaagatac  tacaccatg  cctcaacca  ggattatga  attcaaaga  aaagaatag  1500
acttggacg  tgtattgga  aaggccaat  tggagatgt  catcaaggc  tttatatga  1560
tccagagaa  ccagctttg  cggttgcaa  taaaacatg  aaaaactgt  cttcggaca  1620
cgtgagaga  aaatttctt  aagaagcct  aacaatgcg  cagtttgac  atcctcata  1680
tgtgaagct  attggagtc  tcacagaga  tcctgtctg  ataatcatg  agctgtgca  1740
acttggaga  ctgaggtca  ttttgcaag  aaggaaata  agtttggat  tagcatctt  1800
gatcctgta  gcctatcag  ttagtacag  tcttgcata  ctagagagc  aaagatttg  1860
acacaggga  attgctgct  ggaatgttc  ggtgtcctc  aatgattgt  taaaattag  1920
agactttgg  ttatcccga  atatggaag  tagtactta  tacaaagct  ccaaaggaa  1980
attgcctat  aaatggatg  ctccagagt  aatcaattt  cgacgtttt  cctcagcta  2040
tgacgtatg  atgtttggt  tgtgtatgt  ggagatact  atgcatggt  tgaagcctt  2100
tcaaggagt  aagaacaat  atgtaatcg  tcgaattga  aatggggaa  gattaccaa  2160
gcctccaaa  tgtcctcct  ccctctaca  ccttatgac  aaatgctgg  cctatgacc  2220
cagcaggcg  cccaggttt  ctgaactta  agctcagct  agcacaatc  tggaggaag  2280
gaaggctca  caagaagag  gcatgagga  ggagtccag  agacaggcc  cagtgtcct  2340
ggactccgg  gggtctgat  aagcaccgc  caagcccag  agaccgggt  atcccagtc  2400
gaggtccag  gaaggattt  atcccagcc  acagcacat  gtacaaacc  atcattacc  2460
ggtttctgg  taccctggt  cacatggaa  cacagccat  gctggcagc  tctatccag  2520
tcaggcatc  cttttggac  aaacagatt  atggaatca  agacctcag  agatagcaa  2580
gtggcagcc  aatgtggag  actctacag  attggacct  cgagggatt  ggcaagtgt  2640
gccaaccca  ctgatggaa  agcgtctaa  ccgacagca  caggaaatg  aagaagatc  2700
gcgctggct  gaaaaagag  aaagatttc  gaaacctga  gtgagactc  ctcgaggca  2760
tattgacag  gaggatgga  gtcttcagg  tccgattgg  aaccaacat  tatatcagc  2820
tgtgggtaa  ccagatcct  cagctccac  aaagaaacc  cctcgccct  gagctcccg  2880
tcatctggg  agccttgcc  gcctcagca  ccctgctga  agctacaac  agggtgtca  2940
gcttcagcc  caggaaatc  gcccccctc  tactgccaa  ctggaccgg  cgaatgata  3000
ggtgtacga  aatgtgacg  gcctggtga  agctgtcat  gagatgtcc  gtaaaatcc  3060
gccagcccc  ccagaggag  atgtcccta  ggtgaagga  gtcggcttg  ccctgagga  3120
attattggc  actgtggat  agaccattc  cctcctacc  gccagcacc  accgagaga  3180
tgagatggc  cagaagcta  tgaactctg  cctgggtga  ctcatcaac  agatgaaac  3240
ggcccagca  tatgtcatg  ccagcctcc  gcaagagta  aaaaagcaa  tgctgactg  3300
tgctcacgc  ctggctgtg  atgccaaaa  cttactcga  gtcattgac  aagcaagac  3360
gaaaatgct  gggcagacg  gaccacact  agcctcccc  aggagcacg  cttgctacc  3420
tcttttgaa  atgttctct  gccttccac  agcagcgag  aattaaccc  gtgtcctca  3480
tcgccagca  ttacagctc  aactttttt  aatgaccat  tggttgaaa  atctttctc  3540
tataagttt  accacactt  gatttgggt  cattttttg  tttgttttt  tcaatcatg  3600
tattcagaa  aatccagga  ccaaaatgt  gcgtttttc  aagaatgaa  attatatgt  3660
agcttttaa  catcatgaa  aacaattta  gttcacatt  agatacgtt  taaaggggg  3720
tggccaagg  gtgacatct  aattcctaa  ctaccttag  tgcatagtg  aagaggaga  3780
ctagaagca  a  3791



<210> 7908
<211> 1052
<212> PRT
<213> Homo sapiens
<308> Q05397
<400> 7908

Met Ala Ala Ala Tyr Leu Asp Pro Asn Leu Asn His Thr Pro Asn Ser 
  1               5                  10                  15
Ser Thr Lys Thr His Leu Gly Thr Gly Met Glu Arg Ser Pro Gly Ala 
             20                  25                  30
Met Glu Arg Val Leu Lys Val Phe His Tyr Phe Glu Ser Asn Ser Glu 
         35                  40                  45
Pro Thr Thr Trp Ala Ser Ile Ile Arg His Gly Asp Ala Thr Asp Val 
     50                  55                  60
Arg Gly Ile Ile Gln Lys Ile Val Asp Ser His Lys Val Lys His Val 
 65                  70                  75                  80
Ala Cys Tyr Gly Phe Arg Leu Ser His Leu Arg Ser Glu Glu Val His 
                 85                  90                  95
Trp Leu His Val Asp Met Gly Val Ser Ser Val Arg Glu Lys Tyr Glu 
             100                105                110
Leu Ala His Pro Pro Glu Glu Trp Lys Tyr Glu Leu Arg Ile Arg Tyr 
         115                120                125
Leu Pro Lys Gly Phe Leu Asn Gln Phe Thr Glu Asp Lys Pro Thr Leu 
     130                135                140
Asn Phe Phe Tyr Gln Gln Val Lys Ser Asp Tyr Met Leu Glu Ile Ala 
 145                150                155                160
Asp Gln Val Asp Gln Glu Ile Ala Leu Lys Leu Gly Cys Leu Glu Ile 
                 165                170                175
Arg Arg Ser Tyr Trp Glu Met Arg Gly Asn Ala Leu Glu Lys Lys Ser 
             180                185                190
Asn Tyr Glu Val Leu Glu Lys Asp Val Gly Leu Lys Arg Phe Phe Pro 
         195                200                205
Lys Ser Leu Leu Asp Ser Val Lys Ala Lys Thr Leu Arg Lys Leu Ile 
     210                215                220
Gln Gln Thr Phe Arg Gln Phe Ala Asn Leu Asn Arg Glu Glu Ser Ile 
 225                230                235                240
Leu Lys Phe Phe Glu Ile Leu Ser Pro Val Tyr Arg Phe Asp Lys Glu 
                 245                250                255
Cys Phe Lys Cys Ala Leu Gly Ser Ser Trp Ile Ile Ser Val Glu Leu 
             260                265                270
Ala Ile Gly Pro Glu Glu Gly Ile Ser Tyr Leu Thr Asp Lys Gly Cys 
         275                280                285
Asn Pro Thr His Leu Ala Asp Phe Thr Gln Val Gln Thr Ile Gln Tyr 
     290                295                300
Ser Asn Ser Glu Asp Lys Asp Arg Lys Gly Met Leu Gln Leu Lys Ile 
 305                310                315                320
Ala Gly Ala Pro Glu Pro Leu Thr Val Thr Ala Pro Ser Leu Thr Ile 
                 325                330                335
Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys Arg Leu Val Asn 
             340                345                350
Gly Thr Ser Gln Ser Phe Ile Ile Arg Pro Gln Lys Glu Gly Glu Arg 
         355                360                365
Ala Leu Pro Ser Ile Pro Lys Leu Ala Asn Ser Glu Lys Gln Gly Met 
     370                375                380
Arg Thr His Ala Val Ser Val Ser Glu Thr Asp Asp Tyr Ala Glu Ile 
 385                390                395                400
Ile Asp Glu Glu Asp Thr Tyr Thr Met Pro Ser Thr Arg Asp Tyr Glu 
                 405                410                415
Ile Gln Arg Glu Arg Ile Glu Leu Gly Arg Cys Ile Gly Glu Gly Gln 
             420                425                430
Phe Gly Asp Val His Gln Gly Ile Tyr Met Ser Pro Glu Asn Pro Ala 
         435                440                445
Leu Ala Val Ala Ile Lys Thr Cys Lys Asn Cys Thr Ser Asp Ser Val 
     450                455                460
Arg Glu Lys Phe Leu Gln Glu Ala Leu Thr Met Arg Gln Phe Asp His 
 465                470                475                480
Pro His Ile Val Lys Leu Ile Gly Val Ile Thr Glu Asn Pro Val Trp 
                 485                490                495
Ile Ile Met Glu Leu Cys Thr Leu Gly Glu Leu Arg Ser Phe Leu Gln 
             500                505                510
Val Arg Lys Tyr Ser Leu Asp Leu Ala Ser Leu Ile Leu Tyr Ala Tyr 
         515                520                525
Gln Leu Ser Thr Ala Leu Ala Tyr Leu Glu Ser Lys Arg Phe Val His 
     530                535                540
Arg Asp Ile Ala Ala Arg Asn Val Leu Val Ser Ser Asn Asp Cys Val 
 545                550                555                560
Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Met Glu Asp Ser Thr Tyr 
                 565                570                575
Tyr Lys Ala Ser Lys Gly Lys Leu Pro Ile Lys Trp Met Ala Pro Glu 
             580                585                590
Ser Ile Asn Phe Arg Arg Phe Thr Ser Ala Ser Asp Val Trp Met Phe 
         595                600                605
Gly Val Cys Met Trp Glu Ile Leu Met His Gly Val Lys Pro Phe Gln 
     610                615                620
Gly Val Lys Asn Asn Asp Val Ile Gly Arg Ile Glu Asn Gly Glu Arg 
 625                630                635                640
Leu Pro Met Pro Pro Asn Cys Pro Pro Thr Leu Tyr Ser Leu Met Thr 
                 645                650                655
Lys Cys Trp Ala Tyr Asp Pro Ser Arg Arg Pro Arg Phe Thr Glu Leu 
             660                665                670
Lys Ala Gln Leu Ser Thr Ile Leu Glu Glu Glu Lys Ala Gln Gln Glu 
         675                680                685
Glu Arg Met Arg Met Glu Ser Arg Arg Gln Ala Thr Val Ser Trp Asp 
     690                695                700
Ser Gly Gly Ser Asp Glu Ala Pro Pro Lys Pro Ser Arg Pro Gly Tyr 
 705                710                715                720
Pro Ser Pro Arg Ser Ser Glu Gly Phe Tyr Pro Ser Pro Gln His Met 
                 725                730                735
Val Gln Thr Asn His Tyr Gln Val Ser Gly Tyr Pro Gly Ser His Gly 
             740                745                750
Ile Thr Ala Met Ala Gly Ser Ile Tyr Pro Gly Gln Ala Ser Leu Leu 
         755                760                765
Asp Gln Thr Asp Ser Trp Asn His Arg Pro Gln Glu Ile Ala Met Trp 
     770                775                780
Gln Pro Asn Val Glu Asp Ser Thr Val Leu Asp Leu Arg Gly Ile Gly 
 785                790                795                800
Gln Val Leu Pro Thr His Leu Met Glu Glu Arg Leu Ile Arg Gln Gln 
                 805                810                815
Gln Glu Met Glu Glu Asp Gln Arg Trp Leu Glu Lys Glu Glu Arg Phe 
             820                825                830
Leu Lys Pro Asp Val Arg Leu Ser Arg Gly Ser Ile Asp Arg Glu Asp 
         835                840                845
Gly Ser Leu Gln Gly Pro Ile Gly Asn Gln His Ile Tyr Gln Pro Val 
     850                855                860
Gly Lys Pro Asp Pro Ala Ala Pro Pro Lys Lys Pro Pro Arg Pro Gly 
 865                870                875                880
Ala Pro Gly His Leu Gly Ser Leu Ala Ser Leu Ser Ser Pro Ala Asp 
                 885                890                895
Ser Tyr Asn Glu Gly Val Lys Leu Gln Pro Gln Glu Ile Ser Pro Pro 
             900                905                910
Pro Thr Ala Asn Leu Asp Arg Ser Asn Asp Lys Val Tyr Glu Asn Val 
         915                920                925
Thr Gly Leu Val Lys Ala Val Ile Glu Met Ser Ser Lys Ile Gln Pro 
     930                935                940
Ala Pro Pro Glu Glu Tyr Val Pro Met Val Lys Glu Val Gly Leu Ala 
 945                950                955                960
Leu Arg Thr Leu Leu Ala Thr Val Asp Glu Thr Ile Pro Leu Leu Pro 
                 965                970                975
Ala Ser Thr His Arg Glu Ile Glu Met Ala Gln Lys Leu Leu Asn Ser 
             980                985                990
Asp Leu Gly Glu Leu Ile Asn Lys Met Lys Leu Ala Gln Gln Tyr Val 
         995                1000                1005
Met Thr Ser Leu Gln Gln Glu Tyr Lys Lys Gln Met Leu Thr Ala Ala 
     1010                1015                1020
His Ala Leu Ala Val Asp Ala Lys Asn Leu Leu Asp Val Ile Asp Gln 
 1025                1030                1035                1040
Ala Arg Leu Lys Met Leu Gly Gln Thr Arg Pro His 
                 1045                1050



<210> 7909
<211> 1790
<212> DNA
<213> Rattus norvegicus
<308> S85184
<400> 7909

aattcaggc  gatagtgaa  ggctatcgc  accagaagc  caagaaggg  aggttattt  60
aggaacctc  gatgctgca  atccccaag  ctgtggact  gagagaaaa  ggttgtgtg  120
ctcctgtga  gaatcaggg  cagtgtggt  cttgctggg  ttttagcgc  tcgggttgc  180
tagaaggac  gatgttcct  aagactggc  aactgatct  actgagtga  cagaacctt  240
tggactgtt  tcacgatca  ggcaatcag  gctgtaatg  aggcctgat  gattttgct  300
tccagtaca  taaggaaaa  ggaggtctg  actcagagg  gtcttatcc  tatgaagca  360
aggatggat  ttgtaaata  agagctgag  atgctgtgg  taacgacac  gggtttgtg  420
atatccctc  gcaagagaa  gccctcatg  aggctgtag  gacggtggg  cctatttct  480
ttgccatgg  tgcaagcca  ccgtctctc  agttctata  ttcaggtat  tactatgaa  540
ccaactgta  cagcaagga  ctcgaccat  gggttctgg  ggttggcta  ggttatgaa  600
gaacagatt  aaataagga  aaatactgg  ttgtcaaaa  cagctgggg  aaagaatgg  660
gtatggatg  ctacatcaa  atagccaaa  accggaaca  ccactgcgg  cttgccacc  720
cagccagct  tcctatcgt  aattgatgg  cagcgataa  aaggactta  ggacactac  780
tccgaagga  ttcatctta  aactgacca  acccgtctc  gagtgagac  atggtactt  840
aatcgttca  gatccaagt  acgatttaa  ttctgttga  atttttaca  gggttaaat  900
ttaccacta  ttaaaactc  tgttataaa  agctttata  tattggaca  ttaatgctt  960
attctgatt  tggaatatt  gttttataa  agttgtata  aactttctt  accttttaa  1020
aataaattt  agctcagtg  atgtgtgtg  gtatgggtt  ggggaactt  ctgtgtgaa  1080
tgtgttcac  aatgtttga  actaaagac  gactgattc  agatgtccg  actgattcg  1140
gtgtcagtg  tagacctgg  gaaaggtga  aggtgctct  gatggagcc  tctgatttt  1200
cctcagcgt  ctgtcaggt  aggtatgtg  aagtaaatc  agcttatgg  gtaattgtt  1260
tttctttat  tgtgtgagt  tgtgtgtgt  gaggtcaga  aacaactca  ttctacagt  1320
ttgatccta  cgatcaaaa  caggttgtc  ggctggacc  caggtgcct  ttactactg  1380
ggtatcttg  cagccccac  ggttttaag  gacgtataa  tacatatgt  tatgtagta  1440
aatataatg  gttgtgata  gtgtatact  tgaaatgat  tgatagttc  cctcaaata  1500
tttattact  tgttgaact  ttctagctg  ttctaaaat  cacagtata  tatcattgg  1560
cctgtcttg  taatgtagc  caggctggc  ttaagccat  atcttcctt  tcagccttc  1620
gtgagctaa  ataaaaaaa  aaaatcatg  aatgttata  ccagtctca  gtcttatat  1680
tggcaaacc  tgacagtcc  gaagaacta  agtaaattg  ttgacagtc  tctcaactt  1740
cctaattct  tgacctttc  atatagttc  tcctgttgt  accccaaaaa  1790



<210> 7910
<211> 334
<212> PRT
<213> Rattus norvegicus
<308> AAB21516
<400> 7910

Met Thr Pro Leu Leu Leu Leu Ala Val Leu Cys Leu Gly Thr Ala Leu 
  1               5                  10                  15
Ala Thr Pro Lys Phe Asp Gln Thr Phe Asn Ala Gln Trp His Gln Trp 
             20                  25                  30
Lys Ser Thr His Arg Arg Leu Tyr Gly Thr Asn Glu Glu Glu Trp Arg 
         35                  40                  45
Arg Ala Val Trp Glu Lys Asn Met Arg Met Ile Gln Leu His Asn Gly 
     50                  55                  60
Glu Tyr Ser Asn Gly Lys His Gly Phe Thr Met Glu Met Asn Ala Phe 
 65                  70                  75                  80
Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Ile Val Asn Gly Tyr Arg 
                 85                  90                  95
His Gln Lys His Lys Lys Gly Arg Leu Phe Gln Glu Pro Leu Met Leu 
             100                105                110
Gln Ile Pro Lys Thr Val Asp Trp Arg Glu Lys Gly Cys Val Thr Pro 
         115                120                125
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Ser 
     130                135                140
Gly Cys Leu Glu Gly Gln Met Phe Leu Lys Thr Gly Lys Leu Ile Ser 
 145                150                155                160
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser His Asp Gln Gly Asn Gln 
                 165                170                175
Gly Cys Asn Gly Gly Leu Met Asp Phe Ala Phe Gln Tyr Ile Lys Glu 
             180                185                190
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Lys Asp 
         195                200                205
Gly Ser Cys Lys Tyr Arg Ala Glu Tyr Ala Val Ala Asn Asp Thr Gly 
     210                215                220
Phe Val Asp Ile Pro Gln Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
 225                230                235                240
Thr Val Gly Pro Ile Ser Val Ala Met Asp Ala Ser His Pro Ser Leu 
                 245                250                255
Gln Phe Tyr Ser Ser Gly Ile Tyr Tyr Glu Pro Asn Cys Ser Ser Lys 
             260                265                270
Asp Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Tyr Glu Gly Thr 
         275                280                285
Asp Ser Asn Lys Asp Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Lys 
     290                295                300
Glu Trp Gly Met Asp Gly Tyr Ile Lys Ile Ala Lys Asp Arg Asn Asn 
 305                310                315                320
His Cys Gly Leu Ala Thr Ala Ala Ser Tyr Pro Ile Val Asn 
                 325                330



<210> 7911
<211> 1575
<212> DNA
<213> Homo sapiens
<308> NM_001912
<400> 7911

agaaccgcg  cctccgcaa  cttgagcgg  atccgtgga  tgcgcctgc  gctacgacc  60
cagcaggaa  gcgccgccg  ccaggccca  ctgtggccg  acagggact  gaagagagg  120
cgcggtcga  taggtgtgc  ccagccctg  caacgagag  gtctacccc  aactctgct  180
gccttgagg  ggggaagcc  gggagggca  ttgaggacc  cgcggaggc  cgtgactgg  240
tgagcgggc  ggccagcct  cgagccggg  ggacacagg  tttaaaaca  gaatcctac  300
ctcatcctt  ctgcctttt  cctgggaat  gcctcagct  ctctaacat  tgatcacag  360
ttagaggca  agtggacca  gtggaaggc  atgcacaac  gattatacg  catgaatga  420
gaaggatgg  ggagagcag  gtgggagaa  aacatgaag  tgattgaac  gcacaatca  480
gaatacagg  aagggaaac  cagcttcac  atggccatg  acgcctttg  agacatgac  540
agtgaagaa  tcaggcagg  gatgaatgg  tttcaaaac  gtaagccca  gaaggggaa  600
gtgttccag  aacctctgt  ttatgaggc  cccagatct  tggattgga  agagaaagg  660
tacgtgact  ctgtgaaga  tcagggtca  tgtggttct  gttgggctt  tagtgctac  720
ggtgctctt  aaggacaga  gttccggaa  actgggagg  ttatctcac  gagtgagca  780
aatctggta  actgctctg  gcctcaagg  aatgaaggc  gcaatggtg  cctaatgga  840
tatgctttc  agtatgttc  ggataatgg  ggcctggac  ctgaggaat  ctatccata  900
gaggcaaca  aagaatcct  taagtacaa  cccaagtat  ctgttgcta  tgacaccgg  960
tttgtggac  tccctaagc  ggagaaggc  ctgatgaag  cagttgcaa  tgtggggcc  1020
atttctgtt  ctattgatg  aggtcatga  tccttcctg  tctataaag  aggcattta  1080
tttgagcca  actgtagca  tgaagacat  gatcatggt  tgctggtgg  tggctacgg  1140
tttgaaagc  cagaatcag  taacaataa  tattggctg  tgaagaaca  ctggggtga  1200
gaatggggc  tgggtggct  cgtaaagat  gccaaagac  ggagaaacc  ttgtggaat  1260
gcctcagca  ccagctacc  cactgtgtg  gctggtgga  ggtgatgag  aaggacttg  1320
ctggggatg  cgcatgcat  ggaggaatt  atcttcagt  taccagccc  cgctgtgtc  1380
gatacacac  cgaatcatt  aagatccga  tgtgatttg  attctgtga  attttcaca  1440
tggtaaatg  tacctctat  ttaattact  ctataaata  gtttatatt  ttgattcac  1500
tactgactt  gcattttcg  ttttaaaag  atgtataaa  ttttacctg  ttaaataaa  1560
tttaatttc  aatgt  1575



<210> 7912
<211> 333
<212> PRT
<213> Homo sapiens
<308> P07711
<400> 7912

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
  1               5                  10                  15
Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
             20                  25                  30
Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
         35                  40                  45
Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
     50                  55                  60
Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
 65                  70                  75                  80
Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                 85                  90                  95
Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
             100                105                110
Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
         115                120                125
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
     130                135                140
Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
 145                150                155                160
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                 165                170                175
Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
             180                185                190
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 
         195                200                205
Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 
     210                215                220
Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
 225                230                235                240
Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                 245                250                255
Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
             260                265                270
Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 
         275                280                285
Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
     290                295                300
Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
 305                310                315                320
His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
                 325                330



<210> 7913
<211> 1790
<212> DNA
<213> Rattus norvegicus
<308> S85184
<400> 7913

aattcaggc  gatagtgaa  ggctatcgc  accagaagc  caagaaggg  aggttattt  60
aggaacctc  gatgctgca  atccccaag  ctgtggact  gagagaaaa  ggttgtgtg  120
ctcctgtga  gaatcaggg  cagtgtggt  cttgctggg  ttttagcgc  tcgggttgc  180
tagaaggac  gatgttcct  aagactggc  aactgatct  actgagtga  cagaacctt  240
tggactgtt  tcacgatca  ggcaatcag  gctgtaatg  aggcctgat  gattttgct  300
tccagtaca  taaggaaaa  ggaggtctg  actcagagg  gtcttatcc  tatgaagca  360
aggatggat  ttgtaaata  agagctgag  atgctgtgg  taacgacac  gggtttgtg  420
atatccctc  gcaagagaa  gccctcatg  aggctgtag  gacggtggg  cctatttct  480
ttgccatgg  tgcaagcca  ccgtctctc  agttctata  ttcaggtat  tactatgaa  540
ccaactgta  cagcaagga  ctcgaccat  gggttctgg  ggttggcta  ggttatgaa  600
gaacagatt  aaataagga  aaatactgg  ttgtcaaaa  cagctgggg  aaagaatgg  660
gtatggatg  ctacatcaa  atagccaaa  accggaaca  ccactgcgg  cttgccacc  720
cagccagct  tcctatcgt  aattgatgg  cagcgataa  aaggactta  ggacactac  780
tccgaagga  ttcatctta  aactgacca  acccgtctc  gagtgagac  atggtactt  840
aatcgttca  gatccaagt  acgatttaa  ttctgttga  atttttaca  gggttaaat  900
ttaccacta  ttaaaactc  tgttataaa  agctttata  tattggaca  ttaatgctt  960
attctgatt  tggaatatt  gttttataa  agttgtata  aactttctt  accttttaa  1020
aataaattt  agctcagtg  atgtgtgtg  gtatgggtt  ggggaactt  ctgtgtgaa  1080
tgtgttcac  aatgtttga  actaaagac  gactgattc  agatgtccg  actgattcg  1140
gtgtcagtg  tagacctgg  gaaaggtga  aggtgctct  gatggagcc  tctgatttt  1200
cctcagcgt  ctgtcaggt  aggtatgtg  aagtaaatc  agcttatgg  gtaattgtt  1260
tttctttat  tgtgtgagt  tgtgtgtgt  gaggtcaga  aacaactca  ttctacagt  1320
ttgatccta  cgatcaaaa  caggttgtc  ggctggacc  caggtgcct  ttactactg  1380
ggtatcttg  cagccccac  ggttttaag  gacgtataa  tacatatgt  tatgtagta  1440
aatataatg  gttgtgata  gtgtatact  tgaaatgat  tgatagttc  cctcaaata  1500
tttattact  tgttgaact  ttctagctg  ttctaaaat  cacagtata  tatcattgg  1560
cctgtcttg  taatgtagc  caggctggc  ttaagccat  atcttcctt  tcagccttc  1620
gtgagctaa  ataaaaaaa  aaaatcatg  aatgttata  ccagtctca  gtcttatat  1680
tggcaaacc  tgacagtcc  gaagaacta  agtaaattg  ttgacagtc  tctcaactt  1740
cctaattct  tgacctttc  atatagttc  tcctgttgt  accccaaaaa  1790



<210> 7914
<211> 334
<212> PRT
<213> Rattus norvegicus
<308> AAB21516
<400> 7914

Met Thr Pro Leu Leu Leu Leu Ala Val Leu Cys Leu Gly Thr Ala Leu 
  1               5                  10                  15
Ala Thr Pro Lys Phe Asp Gln Thr Phe Asn Ala Gln Trp His Gln Trp 
             20                  25                  30
Lys Ser Thr His Arg Arg Leu Tyr Gly Thr Asn Glu Glu Glu Trp Arg 
         35                  40                  45
Arg Ala Val Trp Glu Lys Asn Met Arg Met Ile Gln Leu His Asn Gly 
     50                  55                  60
Glu Tyr Ser Asn Gly Lys His Gly Phe Thr Met Glu Met Asn Ala Phe 
 65                  70                  75                  80
Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Ile Val Asn Gly Tyr Arg 
                 85                  90                  95
His Gln Lys His Lys Lys Gly Arg Leu Phe Gln Glu Pro Leu Met Leu 
             100                105                110
Gln Ile Pro Lys Thr Val Asp Trp Arg Glu Lys Gly Cys Val Thr Pro 
         115                120                125
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Ser 
     130                135                140
Gly Cys Leu Glu Gly Gln Met Phe Leu Lys Thr Gly Lys Leu Ile Ser 
 145                150                155                160
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser His Asp Gln Gly Asn Gln 
                 165                170                175
Gly Cys Asn Gly Gly Leu Met Asp Phe Ala Phe Gln Tyr Ile Lys Glu 
             180                185                190
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Lys Asp 
         195                200                205
Gly Ser Cys Lys Tyr Arg Ala Glu Tyr Ala Val Ala Asn Asp Thr Gly 
     210                215                220
Phe Val Asp Ile Pro Gln Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
 225                230                235                240
Thr Val Gly Pro Ile Ser Val Ala Met Asp Ala Ser His Pro Ser Leu 
                 245                250                255
Gln Phe Tyr Ser Ser Gly Ile Tyr Tyr Glu Pro Asn Cys Ser Ser Lys 
             260                265                270
Asp Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Tyr Glu Gly Thr 
         275                280                285
Asp Ser Asn Lys Asp Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Lys 
     290                295                300
Glu Trp Gly Met Asp Gly Tyr Ile Lys Ile Ala Lys Asp Arg Asn Asn 
 305                310                315                320
His Cys Gly Leu Ala Thr Ala Ala Ser Tyr Pro Ile Val Asn 
                 325                330



<210> 7915
<211> 1575
<212> DNA
<213> Homo sapiens
<308> NM_001912
<400> 7915

agaaccgcg  cctccgcaa  cttgagcgg  atccgtgga  tgcgcctgc  gctacgacc  60
cagcaggaa  gcgccgccg  ccaggccca  ctgtggccg  acagggact  gaagagagg  120
cgcggtcga  taggtgtgc  ccagccctg  caacgagag  gtctacccc  aactctgct  180
gccttgagg  ggggaagcc  gggagggca  ttgaggacc  cgcggaggc  cgtgactgg  240
tgagcgggc  ggccagcct  cgagccggg  ggacacagg  tttaaaaca  gaatcctac  300
ctcatcctt  ctgcctttt  cctgggaat  gcctcagct  ctctaacat  tgatcacag  360
ttagaggca  agtggacca  gtggaaggc  atgcacaac  gattatacg  catgaatga  420
gaaggatgg  ggagagcag  gtgggagaa  aacatgaag  tgattgaac  gcacaatca  480
gaatacagg  aagggaaac  cagcttcac  atggccatg  acgcctttg  agacatgac  540
agtgaagaa  tcaggcagg  gatgaatgg  tttcaaaac  gtaagccca  gaaggggaa  600
gtgttccag  aacctctgt  ttatgaggc  cccagatct  tggattgga  agagaaagg  660
tacgtgact  ctgtgaaga  tcagggtca  tgtggttct  gttgggctt  tagtgctac  720
ggtgctctt  aaggacaga  gttccggaa  actgggagg  ttatctcac  gagtgagca  780
aatctggta  actgctctg  gcctcaagg  aatgaaggc  gcaatggtg  cctaatgga  840
tatgctttc  agtatgttc  ggataatgg  ggcctggac  ctgaggaat  ctatccata  900
gaggcaaca  aagaatcct  taagtacaa  cccaagtat  ctgttgcta  tgacaccgg  960
tttgtggac  tccctaagc  ggagaaggc  ctgatgaag  cagttgcaa  tgtggggcc  1020
atttctgtt  ctattgatg  aggtcatga  tccttcctg  tctataaag  aggcattta  1080
tttgagcca  actgtagca  tgaagacat  gatcatggt  tgctggtgg  tggctacgg  1140
tttgaaagc  cagaatcag  taacaataa  tattggctg  tgaagaaca  ctggggtga  1200
gaatggggc  tgggtggct  cgtaaagat  gccaaagac  ggagaaacc  ttgtggaat  1260
gcctcagca  ccagctacc  cactgtgtg  gctggtgga  ggtgatgag  aaggacttg  1320
ctggggatg  cgcatgcat  ggaggaatt  atcttcagt  taccagccc  cgctgtgtc  1380
gatacacac  cgaatcatt  aagatccga  tgtgatttg  attctgtga  attttcaca  1440
tggtaaatg  tacctctat  ttaattact  ctataaata  gtttatatt  ttgattcac  1500
tactgactt  gcattttcg  ttttaaaag  atgtataaa  ttttacctg  ttaaataaa  1560
tttaatttc  aatgt  1575



<210> 7916
<211> 333
<212> PRT
<213> Homo sapiens
<308> P07711
<400> 7916

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
  1               5                  10                  15
Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
             20                  25                  30
Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
         35                  40                  45
Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
     50                  55                  60
Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
 65                  70                  75                  80
Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                 85                  90                  95
Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
             100                105                110
Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
         115                120                125
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
     130                135                140
Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
 145                150                155                160
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                 165                170                175
Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
             180                185                190
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 
         195                200                205
Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 
     210                215                220
Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
 225                230                235                240
Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                 245                250                255
Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
             260                265                270
Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 
         275                280                285
Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
     290                295                300
Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
 305                310                315                320
His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
                 325                330



<210> 7917
<211> 1950
<212> DNA
<213> Rattus norvegicus
<308> S90449
<400> 7917

gaattccgt  taatgagca  attcgtatt  gcaaatatg  aactgccac  gagaggagg  60
gcaggactg  gaccacggg  tgagggtca  gaagactaa  aagaaccaa  tacttaaga  120
accagggtg  agaacaggg  ggaccaaag  cagaggacg  gagctgtgg  cctgcaaag  180
agaaggcag  gcactgagg  cagacaaca  aattcaaaa  agtttggcc  taaaatata  240
acacgctat  ttcctacca  ggggtaaga  aggaggaaa  gggtgtaag  gttaagagg  300
tgtttgggg  atggcggaa  agccgctgg  actctgacc  cctggtaaa  aatggcagt  360
gcgggggag  ttcctgccg  cgcggctgg  gtctctgtt  ctctgtgtc  ggtggctgg  420
agatgctcc  gagagatca  gctgcggcg  aggaggtgg  ggcggccga  tcggcagcg  480
cgctgggtt  gagagaagg  ggcggcggc  gcgtgaggg  ccggacggt  taaacagct  540
gggcggcgg  ggtggccga  cccccgagg  cgaagcggc  gcggaggcg  tgtcgcgtc  600
cgggagaaa  ccgggggcc  cgggcggct  tgcggcggg  aagcccgcg  gaccttgcc  660
tccaccttc  ccccagatt  gttactaaa  atgggtgca  ttttggata  acccaaaac  720
gaaaagcac  atgctcacg  tgcagggaa  ggtctgcgt  acggtctga  cagtatgca  780
ggatggaga  tagaaatgg  agacgcaca  actgctgtt  tgggaattc  tcacggctt  840
gaggactgg  cgttttttg  agtctatga  ggtcatgct  gatcccgag  ggcaaatta  900
tgttcaaca  atctattag  acacatcac  accaatgaa  actttaggg  agctgacaa  960
tcaggcttt  ctcttgagc  gtcagtgga  aatgttaag  ctggtatcc  aactggctt  1020
ttgaaaatt  atgaatata  gcgtaactt  tcagacctg  ggaacggga  ggacaggag  1080
ggctctacc  cagtgggcg  gatgatttc  ccgacacac  tctacttta  caactgcgg  1140
gactcgaga  ctgttctat  taggaatgg  caagtctgc  tttctaccc  ggatcacaa  1200
ccttgtaat  caatggaaa  ggagcgcat  caaaatgca  gaggcagtg  aatgataca  1260
cgtgtgaat  ggtcgttag  agtgtctcg  gctctgggg  actatgatt  caagtgtgt  1320
gatggcaag  gccccacag  gcagcttgt  tctccagag  ctgaggttt  tgagattct  1380
agagcagaa  aggatgaat  tgtcgtcct  gcttgtgat  ggatctggg  tgtgatgag  1440
aatgaggag  tctgtgagt  tgttaactc  aggcttgag  tgtcagacg  cctggagaa  1500
gtgtgcaat  gggtagtgg  cacttgttt  cataaggga  gtcgagata  catgagtat  1560
gtgttagtt  gctttgcaa  tgcccccaa  gtctcagat  aagccgtga  aagagattt  1620
gagttggac  agcacttgg  atcacgggt  gaagaaatc  tgcagaagt  tggagagga  1680
ggaatgcct  atcttgccc  tgtgatgcg  attttgtct  cagaaaata  cccaaattt  1740
cctcccggg  gaggcctcg  tggcaagcg  aatgttatt  aagctgttt  tagtagact  1800
aatccaaac  aagacaatg  tgggggcgc  ggcgatcta  aagactcat  ggtagcctt  1860
taaccttct  aatgctttt  attctgaaa  ttgggggaa  acttttaat  atattttct  1920
caatacaag  ggaactatt  ttgtgaattc  1950



<210> 7918
<211> 390
<212> PRT
<213> Rattus norvegicus
<308> AAB21898
<400> 7918

Met Gly Ala Phe Leu Asp Lys Pro Lys Thr Glu Lys His Asn Ala His 
  1               5                  10                  15
Gly Ala Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
             20                  25                  30
Arg Val Glu Met Glu Asp Ala His Thr Ala Val Val Gly Ile Pro His 
         35                  40                  45
Gly Leu Glu Asp Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
     50                  55                  60
Ser Arg Val Ala Asn Tyr Cys Ser Thr His Leu Leu Glu His Ile Thr 
 65                  70                  75                  80
Thr Asn Glu Asp Phe Arg Ala Ala Asp Lys Ser Gly Phe Ala Leu Glu 
                 85                  90                  95
Pro Ser Val Glu Asn Val Lys Thr Gly Ile Arg Thr Gly Phe Leu Lys 
             100                105                110
Ile Asp Glu Tyr Met Arg Asn Phe Ser Asp Leu Arg Asn Gly Met Asp 
         115                120                125
Arg Ser Gly Ser Thr Ala Val Gly Val Met Ile Ser Pro Thr His Ile 
     130                135                140
Tyr Phe Ile Asn Cys Gly Asp Ser Arg Ala Val Leu Cys Arg Asn Gly 
 145                150                155                160
Gln Val Cys Phe Ser Thr Gln Asp His Lys Pro Cys Asn Pro Met Glu 
                 165                170                175
Lys Glu Arg Ile Gln Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val 
             180                185                190
Asn Gly Ser Leu Ala Val Ser Arg Ala Leu Gly Asp Tyr Asp Tyr Lys 
         195                200                205
Cys Val Asp Gly Lys Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro 
     210                215                220
Glu Val Tyr Glu Ile Leu Arg Ala Glu Glu Asp Glu Phe Val Val Leu 
 225                230                235                240
Ala Cys Asp Gly Ile Trp Asp Val Met Ser Asn Glu Glu Leu Cys Glu 
                 245                250                255
Phe Val Asn Ser Arg Leu Glu Val Ser Asp Asp Leu Glu Asn Val Cys 
             260                265                270
Asn Trp Val Val Asp Thr Cys Leu His Lys Gly Ser Arg Asp Asn Met 
         275                280                285
Ser Ile Val Leu Val Cys Phe Ala Asn Ala Pro Lys Val Ser Asp Glu 
     290                295                300
Ala Val Lys Arg Asp Leu Glu Leu Asp Lys His Leu Glu Ser Arg Val 
 305                310                315                320
Glu Glu Ile Met Gln Lys Ser Gly Glu Glu Gly Met Pro Asp Leu Ala 
                 325                330                335
His Val Met Arg Ile Leu Ser Ala Glu Asn Ile Pro Asn Leu Pro Pro 
             340                345                350
Gly Gly Gly Leu Ala Gly Lys Arg Asn Val Ile Glu Ala Val Tyr Ser 
         355                360                365
Arg Leu Asn Pro Asn Lys Asp Asn Asp Gly Gly Ala Gly Asp Leu Glu 
     370                375                380
Asp Ser Leu Val Ala Leu 
 385                390



<210> 7919
<211> 1753
<212> DNA
<213> Rattus norvegicus
<308> U01227
<400> 7919

ggaaaggca  ccggaggag  gccacccag  cccacagca  cacccagcc  gctctgctg  60
ggctgtcag  tcacctcct  gctaactac  agaaggggg  gcggcctgt  cgggactgg  120
ggaagccca  cctggtctc  atcgatgtc  tcatgtatg  catcctcaa  gtggatgag  180
agaaccagg  tctgacaac  tacatatgg  accggcagt  ctggaccga  gagtttcta  240
agtggactc  tgaggactt  gacaatgtc  ccaaattgt  catccccac  gacagcatc  300
gggtccctg  catcctcat  aatgagttt  tggacgtgg  gaagtctcc  agcattcct  360
atgtgtatg  gcaccatca  ggtgaagtc  agaactaca  gcccctaca  ctggtgacc  420
cctgtagcc  tgacatcta  aacttcccg  tcgatgtgc  gaactgctc  ctgaccttc  480
ccagctggc  gcataccat  caggacatc  acatttccc  gtggcgaac  ccagaagaa  540
tgaggtcgg  caagagcat  ttcataaat  agggcgagt  ggagctgct  ggggtgttc  600
ccaaatttc  ggagttcag  atagaaacc  gtaacagct  tgcggaaat  aagttctac  660
tggtcatcc  ccggcggcc  ttattctac  cagtcagcc  cttgctgcc  agtatcttc  720
tcatggtcg  ggacattgt  ggcttttgt  tgcccccgg  cagtggtga  agagtgtct  780
tcaagatca  gctccttct  ggatactca  tctttctca  catcgtgtc  gacacactg  840
ctgcaacgg  catccgcac  cccctcatt  gtgtctact  tgtagtgtg  atggctctg  900
tggtgataa  cctcgctga  accatcttc  ttgtgcagc  ggtgcataa  caggattta  960
agcgccctg  acctgactg  ctgaggcac  tggtcctag  cagaatagc  tggctgctc  1020
gcctagggg  gcagcccat  gcccatagg  ccccagcca  cttccaagc  aacaagact  1080
atgactgct  agccatggg  aaccactgc  gccatgtcg  aagccctca  gacttggag  1140
agacctcga  gagcagaga  agccctctt  caccaccaa  ggaggcctc  ctggctgtg  1200
gtggcctct  gcaagagct  tcctccatc  gccactccc  ggagaagcg  gatgagatg  1260
gggaggtgg  aagggactg  ttgcgggtg  gatatgtgc  ggacaggct  ctgtttcgc  1320
tctacctgc  ggccgtgct  gcttacagc  tcaccctgg  cacgctctg  tccatttgg  1380
attattcct  agtgggtac  gcctggcag  gaggggatg  gagtcctgc  tcctgtttc  1440
aacaccaat  catctgagc  accccagtc  ccttgtccc  taaacttag  actgaagac  1500
cggtcagac  ccccgactt  gctatcatg  ctttaaagc  tgatatcct  ttccagtac  1560
tctgtgatt  tggcccttg  gatggctca  ttccacagt  tttttttcc  ttttgatca  1620
aggaaagca  attctcttg  ctaggtgcc  gagacgtct  tgcctgttt  atccaggcc  1680
cagtggctt  ttcttcagc  cacttgtgg  tacttccct  gcgctcagc  tcatcaacc  1740
acgggggga  ggg  1753



<210> 7920
<211> 483
<212> PRT
<213> Rattus norvegicus
<308> AAA52182
<400> 7920

Met Pro Leu Cys Ile Pro Gln Val Leu Leu Ala Leu Phe Leu Ser Val 
  1               5                  10                  15
Leu Ile Ala Gln Gly Glu Gly Ser Arg Arg Arg Ala Thr Gln Ala His 
             20                  25                  30
Ser Thr Thr Gln Pro Ala Leu Leu Arg Leu Ser Asp His Leu Leu Ala 
         35                  40                  45
Asn Tyr Lys Lys Gly Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr 
     50                  55                  60
Leu Val Ser Ile Asp Val Ile Met Tyr Ala Ile Leu Asn Val Asp Glu 
 65                  70                  75                  80
Lys Asn Gln Val Leu Thr Thr Tyr Ile Trp Tyr Arg Gln Phe Trp Thr 
                 85                  90                  95
Asp Glu Phe Leu Gln Trp Thr Pro Glu Asp Phe Asp Asn Val Thr Lys 
             100                105                110
Leu Ser Ile Pro Thr Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn 
         115                120                125
Glu Phe Val Asp Val Gly Lys Ser Pro Ser Ile Pro Tyr Val Tyr Val 
     130                135                140
His His Gln Gly Glu Val Gln Asn Tyr Lys Pro Leu Gln Leu Val Thr 
 145                150                155                160
Ala Cys Ser Leu Asp Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys 
                 165                170                175
Ser Leu Thr Phe Thr Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile 
             180                185                190
Ser Leu Trp Arg Thr Pro Glu Glu Val Arg Ser Asp Lys Ser Ile Phe 
         195                200                205
Ile Asn Gln Gly Glu Trp Glu Leu Leu Gly Val Phe Thr Lys Phe Gln 
     210                215                220
Glu Phe Ser Ile Glu Thr Ser Asn Ser Tyr Ala Glu Met Lys Phe Tyr 
 225                230                235                240
Val Val Ile Arg Arg Arg Pro Leu Phe Tyr Ala Val Ser Leu Leu Leu 
                 245                250                255
Pro Ser Ile Phe Leu Met Val Val Asp Ile Val Gly Phe Cys Leu Pro 
             260                265                270
Pro Asp Ser Gly Glu Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly 
         275                280                285
Tyr Ser Val Phe Leu Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala 
     290                295                300
Ile Gly Thr Pro Leu Ile Gly Val Tyr Phe Val Val Cys Met Ala Leu 
 305                310                315                320
Leu Val Ile Ser Leu Ala Glu Thr Ile Phe Ile Val Gln Leu Val His 
                 325                330                335
Lys Gln Asp Leu Gln Arg Pro Val Pro Asp Trp Leu Arg His Leu Val 
             340                345                350
Leu Asp Arg Ile Ala Trp Leu Leu Cys Leu Gly Glu Gln Pro Met Ala 
         355                360                365
His Arg Pro Pro Ala Thr Phe Gln Ala Asn Lys Thr Asp Asp Cys Ser 
     370                375                380
Ala Met Gly Asn His Cys Ser His Val Gly Ser Pro Gln Asp Leu Glu 
 385                390                395                400
Lys Thr Ser Arg Ser Arg Asp Ser Pro Leu Pro Pro Pro Arg Glu Ala 
                 405                410                415
Ser Leu Ala Val Arg Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg His 
             420                425                430
Ser Leu Glu Lys Arg Asp Glu Met Arg Glu Val Ala Arg Asp Trp Leu 
         435                440                445
Arg Val Gly Tyr Val Leu Asp Arg Leu Leu Phe Arg Ile Tyr Leu Leu 
     450                455                460
Ala Val Leu Ala Tyr Ser Ile Thr Leu Val Thr Leu Trp Ser Ile Trp 
 465                470                475                480
His Tyr Ser 
                 485



<210> 7921
<211> 2202
<212> DNA
<213> Homo sapiens
<308> NM_000869
<400> 7921

ggaaacatg  tccagctga  ggactgatt  caggaaaac  tggcagctc  ccaaccttg  60
tggcccagg  agtgtgagg  tgcagcctc  gaaggtgtg  gcagtggcc  cgagaggca  120
gctggctgg  acatgaggt  ggcagaggg  aggcaagct  gcccttggt  ggcctcgcc  180
tgagcactc  gaggcactc  tatgcttgg  aagctcgct  tgctgctgt  ggtccagca  240
gcgctgctc  ccttgctcc  ccccacact  ctggcacag  gagaagcca  gaggagccg  300
aacaccacc  ggcccgctc  gctgaggct  tcggattac  ttttgacca  ctacaggaa  360
ggtgtgcgc  ccgtgaggg  ctggaggaa  ccaaccacc  tatccattg  cgtcattgt  420
tatgccatc  tcaacgtgg  tgagaagaa  caggtgctg  ccacctaca  ctggtaccg  480
cagtactgg  ctgatgagt  tctccagtg  aaccctgag  actttgaca  catcaccaa  540
ttgtccatc  ccacggaca  catctgggt  ccggacatt  tcatcaatg  gttcgtgga  600
gtggggaag  ctccaaata  cccgtacgt  tatattcgg  atcaaggcg  agttcagaa  660
tacaagccc  ttcaggtgg  gactgcctg  agcctcgac  tctacaact  ccccttcga  720
gtccagaac  gctcgctga  cttcaccag  tggctgcac  ccatccagg  catcaacat  780
tctttgtgg  gcttgccag  aaaggtgaa  tccgacagg  gtgtcttca  gaaccaggg  840
gagtgggag  tgctggggg  gctgcccta  tttcgggag  tcagcatgg  aagcagtaa  900
tactatgca  aaatgaagt  ctatgtggt  atccgccgg  ggcccctct  ctatgtggt  960
agcctgcta  tgcccagca  cttcctcat  gtcatggac  tcgtgggct  ctacctgcc  1020
cccaacagt  gcgagaggg  ctctttcaa  attacactc  tcctgggct  ctcggtctt  1080
ctgatcatc  tttctgaca  gctgccggc  actgccatc  gcactcctc  cattggtgt  1140
tactttgtg  tgtgcatgg  tctgctggt  ataagtttg  ccgagacca  cttcattgt  1200
cggctggtg  acaagcaag  cctgcagca  cccgtgcct  cttggctgc  tcacctggt  1260
ctggagaga  tcgcctggc  actttgcct  agggagcag  caacttccc  gaggccccc  1320
gccacctcc  aagccacca  gactgatga  tgctcagcc  tgggaaacc  ctgcagcca  1380
atgggagga  cccaggact  cgagaagag  ccgagggac  gatgtagcc  tcccccacc  1440
cctcgggag  cctcgctgg  ggtgtgtgg  ctgctgcag  agctgtcct  catccggca  1500
ttcctggaa  agcgggatg  gatccgaga  gtggcccga  actggctgc  cgtgggctc  1560
gtgctggac  agctgctat  ccacattta  ctgctagcg  tgctggcct  cagcatcac  1620
ctggttatg  tctggtcca  ctggcagta  gcttgagtg  gtacagccc  gtggaggag  1680
gggtacagt  ctggttagg  ggggacaga  gatttctgc  taggcccct  aggacccag  1740
gaatgccag  gacattttc  agacacaga  aaagtcccg  gccctgttt  caatgccaa  1800
tcatctcag  aatcacaag  caaggtctg  acccttcca  caaaaactg  gtgttcaag  1860
cccttacac  cttgtccca  ccccagcag  tcaccatgg  tttaaaaca  gctctctta  1920
atcaggaga  actcgggca  tccctaagt  cactctagt  gtggacttt  ccccattga  1980
cctcacctg  ataagggac  ttggaattc  gcttctctt  cacaacttt  cttttaggt  2040
gaaggcaaa  ccaactctc  actacacag  cctgataac  ctgtacgag  cttctctaa  2100
ccctagtgt  ttttttttc  tcacctcac  tgtggcagc  tccctgaac  ctcatcccc  2160
atcagatga  gggagtggg  agaataaaa  gcagtgaaa  cc  2202



<210> 7922
<211> 478
<212> PRT
<213> Homo sapiens
<308> P46098
<400> 7922

Met Leu Leu Trp Val Gln Gln Ala Leu Leu Ala Leu Leu Leu Pro Thr 
  1               5                  10                  15
Leu Leu Ala Gln Gly Glu Ala Arg Arg Ser Arg Asn Thr Thr Arg Pro 
             20                  25                  30
Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu Thr Asn Tyr Arg Lys Gly 
         35                  40                  45
Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr Thr Val Ser Ile Asp 
     50                  55                  60
Val Ile Val Tyr Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val Leu 
 65                  70                  75                  80
Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp Thr Asp Glu Phe Leu Gln 
                 85                  90                  95
Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr Lys Leu Ser Ile Pro Thr 
             100                105                110
Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn Glu Phe Val Asp Val 
         115                120                125
Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr Ile Arg His Gln Gly Glu 
     130                135                140
Val Gln Asn Tyr Lys Pro Leu Gln Val Val Thr Ala Cys Ser Leu Asp 
 145                150                155                160
Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Thr 
                 165                170                175
Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile Ser Leu Trp Arg Leu 
             180                185                190
Pro Glu Lys Val Lys Ser Asp Arg Ser Val Phe Met Asn Gln Gly Glu 
         195                200                205
Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe Arg Glu Phe Ser Met Glu 
     210                215                220
Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe Tyr Val Val Ile Arg Arg 
 225                230                235                240
Arg Pro Leu Phe Tyr Val Val Ser Leu Leu Leu Pro Ser Ile Phe Leu 
                 245                250                255
Met Val Met Asp Ile Val Gly Phe Tyr Leu Pro Pro Asn Ser Gly Glu 
             260                265                270
Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly Tyr Ser Val Phe Leu 
         275                280                285
Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala Ile Gly Thr Pro Leu 
     290                295                300
Ile Gly Val Tyr Phe Val Val Cys Met Ala Leu Leu Val Ile Ser Leu 
 305                310                315                320
Ala Glu Thr Ile Phe Ile Val Arg Leu Val His Lys Gln Asp Leu Gln 
                 325                330                335
Gln Pro Val Pro Ala Trp Leu Arg His Leu Val Leu Glu Arg Ile Ala 
             340                345                350
Trp Leu Leu Cys Leu Arg Glu Gln Ser Thr Ser Gln Arg Pro Pro Ala 
         355                360                365
Thr Ser Gln Ala Thr Lys Thr Asp Asp Cys Ser Ala Met Gly Asn His 
     370                375                380
Cys Ser His Met Gly Gly Pro Gln Asp Phe Glu Lys Ser Pro Arg Asp 
 385                390                395                400
Arg Cys Ser Pro Pro Pro Pro Pro Arg Glu Ala Ser Leu Ala Val Cys 
                 405                410                415
Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg Gln Phe Leu Glu Lys Arg 
             420                425                430
Asp Glu Ile Arg Glu Val Ala Arg Asp Trp Leu Arg Val Gly Ser Val 
         435                440                445
Leu Asp Lys Leu Leu Phe His Ile Tyr Leu Leu Ala Val Leu Ala Tyr 
     450                455                460
Ser Ile Thr Leu Val Met Leu Trp Ser Ile Trp Gln Tyr Ala 
 465                470                475



<210> 7923
<211> 1753
<212> DNA
<213> Rattus norvegicus
<308> U01227
<400> 7923

ggaaaggca  ccggaggag  gccacccag  cccacagca  cacccagcc  gctctgctg  60
ggctgtcag  tcacctcct  gctaactac  agaaggggg  gcggcctgt  cgggactgg  120
ggaagccca  cctggtctc  atcgatgtc  tcatgtatg  catcctcaa  gtggatgag  180
agaaccagg  tctgacaac  tacatatgg  accggcagt  ctggaccga  gagtttcta  240
agtggactc  tgaggactt  gacaatgtc  ccaaattgt  catccccac  gacagcatc  300
gggtccctg  catcctcat  aatgagttt  tggacgtgg  gaagtctcc  agcattcct  360
atgtgtatg  gcaccatca  ggtgaagtc  agaactaca  gcccctaca  ctggtgacc  420
cctgtagcc  tgacatcta  aacttcccg  tcgatgtgc  gaactgctc  ctgaccttc  480
ccagctggc  gcataccat  caggacatc  acatttccc  gtggcgaac  ccagaagaa  540
tgaggtcgg  caagagcat  ttcataaat  agggcgagt  ggagctgct  ggggtgttc  600
ccaaatttc  ggagttcag  atagaaacc  gtaacagct  tgcggaaat  aagttctac  660
tggtcatcc  ccggcggcc  ttattctac  cagtcagcc  cttgctgcc  agtatcttc  720
tcatggtcg  ggacattgt  ggcttttgt  tgcccccgg  cagtggtga  agagtgtct  780
tcaagatca  gctccttct  ggatactca  tctttctca  catcgtgtc  gacacactg  840
ctgcaacgg  catccgcac  cccctcatt  gtgtctact  tgtagtgtg  atggctctg  900
tggtgataa  cctcgctga  accatcttc  ttgtgcagc  ggtgcataa  caggattta  960
agcgccctg  acctgactg  ctgaggcac  tggtcctag  cagaatagc  tggctgctc  1020
gcctagggg  gcagcccat  gcccatagg  ccccagcca  cttccaagc  aacaagact  1080
atgactgct  agccatggg  aaccactgc  gccatgtcg  aagccctca  gacttggag  1140
agacctcga  gagcagaga  agccctctt  caccaccaa  ggaggcctc  ctggctgtg  1200
gtggcctct  gcaagagct  tcctccatc  gccactccc  ggagaagcg  gatgagatg  1260
gggaggtgg  aagggactg  ttgcgggtg  gatatgtgc  ggacaggct  ctgtttcgc  1320
tctacctgc  ggccgtgct  gcttacagc  tcaccctgg  cacgctctg  tccatttgg  1380
attattcct  agtgggtac  gcctggcag  gaggggatg  gagtcctgc  tcctgtttc  1440
aacaccaat  catctgagc  accccagtc  ccttgtccc  taaacttag  actgaagac  1500
cggtcagac  ccccgactt  gctatcatg  ctttaaagc  tgatatcct  ttccagtac  1560
tctgtgatt  tggcccttg  gatggctca  ttccacagt  tttttttcc  ttttgatca  1620
aggaaagca  attctcttg  ctaggtgcc  gagacgtct  tgcctgttt  atccaggcc  1680
cagtggctt  ttcttcagc  cacttgtgg  tacttccct  gcgctcagc  tcatcaacc  1740
acgggggga  ggg  1753



<210> 7924
<211> 483
<212> PRT
<213> Rattus norvegicus
<308> AAA52182
<400> 7924

Met Pro Leu Cys Ile Pro Gln Val Leu Leu Ala Leu Phe Leu Ser Val 
  1               5                  10                  15
Leu Ile Ala Gln Gly Glu Gly Ser Arg Arg Arg Ala Thr Gln Ala His 
             20                  25                  30
Ser Thr Thr Gln Pro Ala Leu Leu Arg Leu Ser Asp His Leu Leu Ala 
         35                  40                  45
Asn Tyr Lys Lys Gly Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr 
     50                  55                  60
Leu Val Ser Ile Asp Val Ile Met Tyr Ala Ile Leu Asn Val Asp Glu 
 65                  70                  75                  80
Lys Asn Gln Val Leu Thr Thr Tyr Ile Trp Tyr Arg Gln Phe Trp Thr 
                 85                  90                  95
Asp Glu Phe Leu Gln Trp Thr Pro Glu Asp Phe Asp Asn Val Thr Lys 
             100                105                110
Leu Ser Ile Pro Thr Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn 
         115                120                125
Glu Phe Val Asp Val Gly Lys Ser Pro Ser Ile Pro Tyr Val Tyr Val 
     130                135                140
His His Gln Gly Glu Val Gln Asn Tyr Lys Pro Leu Gln Leu Val Thr 
 145                150                155                160
Ala Cys Ser Leu Asp Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys 
                 165                170                175
Ser Leu Thr Phe Thr Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile 
             180                185                190
Ser Leu Trp Arg Thr Pro Glu Glu Val Arg Ser Asp Lys Ser Ile Phe 
         195                200                205
Ile Asn Gln Gly Glu Trp Glu Leu Leu Gly Val Phe Thr Lys Phe Gln 
     210                215                220
Glu Phe Ser Ile Glu Thr Ser Asn Ser Tyr Ala Glu Met Lys Phe Tyr 
 225                230                235                240
Val Val Ile Arg Arg Arg Pro Leu Phe Tyr Ala Val Ser Leu Leu Leu 
                 245                250                255
Pro Ser Ile Phe Leu Met Val Val Asp Ile Val Gly Phe Cys Leu Pro 
             260                265                270
Pro Asp Ser Gly Glu Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly 
         275                280                285
Tyr Ser Val Phe Leu Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala 
     290                295                300
Ile Gly Thr Pro Leu Ile Gly Val Tyr Phe Val Val Cys Met Ala Leu 
 305                310                315                320
Leu Val Ile Ser Leu Ala Glu Thr Ile Phe Ile Val Gln Leu Val His 
                 325                330                335
Lys Gln Asp Leu Gln Arg Pro Val Pro Asp Trp Leu Arg His Leu Val 
             340                345                350
Leu Asp Arg Ile Ala Trp Leu Leu Cys Leu Gly Glu Gln Pro Met Ala 
         355                360                365
His Arg Pro Pro Ala Thr Phe Gln Ala Asn Lys Thr Asp Asp Cys Ser 
     370                375                380
Ala Met Gly Asn His Cys Ser His Val Gly Ser Pro Gln Asp Leu Glu 
 385                390                395                400
Lys Thr Ser Arg Ser Arg Asp Ser Pro Leu Pro Pro Pro Arg Glu Ala 
                 405                410                415
Ser Leu Ala Val Arg Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg His 
             420                425                430
Ser Leu Glu Lys Arg Asp Glu Met Arg Glu Val Ala Arg Asp Trp Leu 
         435                440                445
Arg Val Gly Tyr Val Leu Asp Arg Leu Leu Phe Arg Ile Tyr Leu Leu 
     450                455                460
Ala Val Leu Ala Tyr Ser Ile Thr Leu Val Thr Leu Trp Ser Ile Trp 
 465                470                475                480
His Tyr Ser 
                 485



<210> 7925
<211> 2202
<212> DNA
<213> Homo sapiens
<308> NM_000869
<400> 7925

ggaaacatg  tccagctga  ggactgatt  caggaaaac  tggcagctc  ccaaccttg  60
tggcccagg  agtgtgagg  tgcagcctc  gaaggtgtg  gcagtggcc  cgagaggca  120
gctggctgg  acatgaggt  ggcagaggg  aggcaagct  gcccttggt  ggcctcgcc  180
tgagcactc  gaggcactc  tatgcttgg  aagctcgct  tgctgctgt  ggtccagca  240
gcgctgctc  ccttgctcc  ccccacact  ctggcacag  gagaagcca  gaggagccg  300
aacaccacc  ggcccgctc  gctgaggct  tcggattac  ttttgacca  ctacaggaa  360
ggtgtgcgc  ccgtgaggg  ctggaggaa  ccaaccacc  tatccattg  cgtcattgt  420
tatgccatc  tcaacgtgg  tgagaagaa  caggtgctg  ccacctaca  ctggtaccg  480
cagtactgg  ctgatgagt  tctccagtg  aaccctgag  actttgaca  catcaccaa  540
ttgtccatc  ccacggaca  catctgggt  ccggacatt  tcatcaatg  gttcgtgga  600
gtggggaag  ctccaaata  cccgtacgt  tatattcgg  atcaaggcg  agttcagaa  660
tacaagccc  ttcaggtgg  gactgcctg  agcctcgac  tctacaact  ccccttcga  720
gtccagaac  gctcgctga  cttcaccag  tggctgcac  ccatccagg  catcaacat  780
tctttgtgg  gcttgccag  aaaggtgaa  tccgacagg  gtgtcttca  gaaccaggg  840
gagtgggag  tgctggggg  gctgcccta  tttcgggag  tcagcatgg  aagcagtaa  900
tactatgca  aaatgaagt  ctatgtggt  atccgccgg  ggcccctct  ctatgtggt  960
agcctgcta  tgcccagca  cttcctcat  gtcatggac  tcgtgggct  ctacctgcc  1020
cccaacagt  gcgagaggg  ctctttcaa  attacactc  tcctgggct  ctcggtctt  1080
ctgatcatc  tttctgaca  gctgccggc  actgccatc  gcactcctc  cattggtgt  1140
tactttgtg  tgtgcatgg  tctgctggt  ataagtttg  ccgagacca  cttcattgt  1200
cggctggtg  acaagcaag  cctgcagca  cccgtgcct  cttggctgc  tcacctggt  1260
ctggagaga  tcgcctggc  actttgcct  agggagcag  caacttccc  gaggccccc  1320
gccacctcc  aagccacca  gactgatga  tgctcagcc  tgggaaacc  ctgcagcca  1380
atgggagga  cccaggact  cgagaagag  ccgagggac  gatgtagcc  tcccccacc  1440
cctcgggag  cctcgctgg  ggtgtgtgg  ctgctgcag  agctgtcct  catccggca  1500
ttcctggaa  agcgggatg  gatccgaga  gtggcccga  actggctgc  cgtgggctc  1560
gtgctggac  agctgctat  ccacattta  ctgctagcg  tgctggcct  cagcatcac  1620
ctggttatg  tctggtcca  ctggcagta  gcttgagtg  gtacagccc  gtggaggag  1680
gggtacagt  ctggttagg  ggggacaga  gatttctgc  taggcccct  aggacccag  1740
gaatgccag  gacattttc  agacacaga  aaagtcccg  gccctgttt  caatgccaa  1800
tcatctcag  aatcacaag  caaggtctg  acccttcca  caaaaactg  gtgttcaag  1860
cccttacac  cttgtccca  ccccagcag  tcaccatgg  tttaaaaca  gctctctta  1920
atcaggaga  actcgggca  tccctaagt  cactctagt  gtggacttt  ccccattga  1980
cctcacctg  ataagggac  ttggaattc  gcttctctt  cacaacttt  cttttaggt  2040
gaaggcaaa  ccaactctc  actacacag  cctgataac  ctgtacgag  cttctctaa  2100
ccctagtgt  ttttttttc  tcacctcac  tgtggcagc  tccctgaac  ctcatcccc  2160
atcagatga  gggagtggg  agaataaaa  gcagtgaaa  cc  2202



<210> 7926
<211> 478
<212> PRT
<213> Homo sapiens
<308> P46098
<400> 7926

Met Leu Leu Trp Val Gln Gln Ala Leu Leu Ala Leu Leu Leu Pro Thr 
  1               5                  10                  15
Leu Leu Ala Gln Gly Glu Ala Arg Arg Ser Arg Asn Thr Thr Arg Pro 
             20                  25                  30
Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu Thr Asn Tyr Arg Lys Gly 
         35                  40                  45
Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr Thr Val Ser Ile Asp 
     50                  55                  60
Val Ile Val Tyr Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val Leu 
 65                  70                  75                  80
Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp Thr Asp Glu Phe Leu Gln 
                 85                  90                  95
Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr Lys Leu Ser Ile Pro Thr 
             100                105                110
Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn Glu Phe Val Asp Val 
         115                120                125
Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr Ile Arg His Gln Gly Glu 
     130                135                140
Val Gln Asn Tyr Lys Pro Leu Gln Val Val Thr Ala Cys Ser Leu Asp 
 145                150                155                160
Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Thr 
                 165                170                175
Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile Ser Leu Trp Arg Leu 
             180                185                190
Pro Glu Lys Val Lys Ser Asp Arg Ser Val Phe Met Asn Gln Gly Glu 
         195                200                205
Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe Arg Glu Phe Ser Met Glu 
     210                215                220
Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe Tyr Val Val Ile Arg Arg 
 225                230                235                240
Arg Pro Leu Phe Tyr Val Val Ser Leu Leu Leu Pro Ser Ile Phe Leu 
                 245                250                255
Met Val Met Asp Ile Val Gly Phe Tyr Leu Pro Pro Asn Ser Gly Glu 
             260                265                270
Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly Tyr Ser Val Phe Leu 
         275                280                285
Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala Ile Gly Thr Pro Leu 
     290                295                300
Ile Gly Val Tyr Phe Val Val Cys Met Ala Leu Leu Val Ile Ser Leu 
 305                310                315                320
Ala Glu Thr Ile Phe Ile Val Arg Leu Val His Lys Gln Asp Leu Gln 
                 325                330                335
Gln Pro Val Pro Ala Trp Leu Arg His Leu Val Leu Glu Arg Ile Ala 
             340                345                350
Trp Leu Leu Cys Leu Arg Glu Gln Ser Thr Ser Gln Arg Pro Pro Ala 
         355                360                365
Thr Ser Gln Ala Thr Lys Thr Asp Asp Cys Ser Ala Met Gly Asn His 
     370                375                380
Cys Ser His Met Gly Gly Pro Gln Asp Phe Glu Lys Ser Pro Arg Asp 
 385                390                395                400
Arg Cys Ser Pro Pro Pro Pro Pro Arg Glu Ala Ser Leu Ala Val Cys 
                 405                410                415
Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg Gln Phe Leu Glu Lys Arg 
             420                425                430
Asp Glu Ile Arg Glu Val Ala Arg Asp Trp Leu Arg Val Gly Ser Val 
         435                440                445
Leu Asp Lys Leu Leu Phe His Ile Tyr Leu Leu Ala Val Leu Ala Tyr 
     450                455                460
Ser Ile Thr Leu Val Met Leu Trp Ser Ile Trp Gln Tyr Ala 
 465                470                475



<210> 7927
<211> 2533
<212> DNA
<213> Rattus norvegicus
<308> U01344
<400> 7927

ggagaggag  ggagaggga  agccagcca  gaacacatg  agagagggg  ggggatgtg  60
aaagaggga  aaggcgcag  gagtaagag  gcaagggcg  caaacagcc  ctttaagag  120
aagccaggc  tgcctggct  atgccaggt  actgtgggg  cagagccta  aggggatgc  180
aacagagct  atctcagtc  actcttctc  cccagtctg  cccagtcac  ctgtctttg  240
atccacccc  tctgctagg  aacaccatc  tcacacatc  gtggagctc  ctgtctgtc  300
tccttcgga  gcaagtgtg  ctttcttca  ccatattag  tcccatcaa  actctcctt  360
tacctctct  ttttagtta  cctgtggac  gctactaca  ttctctttt  tgtttttaa  420
ttacttatg  attatttta  tacccactg  aatgcaaga  tttggaggg  aagaaagca  480
agcaagtat  taaaggatg  tcagtgaag  gatgacttg  tcaatcagt  tagctcatt  540
agtaaggag  ctcatagag  acccagtgc  gtgatgaat  ggtcactcg  catggcatt  600
tctagtgtg  aagtctccc  tttttgtga  taactgttt  aaagattat  ttggcaata  660
ctacctttc  tcaccaagg  aaccacatc  aatctctct  ttgactggt  atttagcct  720
attttctac  tcaaaaact  gaaagatac  aggaataac  aaactttcc  ctaaggctc  780
ctgagagta  ttaatgaac  gcaggtaaa  gcaagccag  ctgtagagg  gacatgatt  840
cctaggagc  atgtagagg  atctttcat  tatacacgt  aacaacaca  tcgaactac  900
gttagctga  tctgggaca  ccagaagaa  tgatgtcat  tttgtctgc  ttcatcctg  960
ttgccttag  gagccatgg  catcgaagc  tacttcgaa  ggattggtt  caagaactc  1020
gtgaataag  tggacttgg  cacattaac  gaagttctt  aacaccaga  gcgagcagt  1080
ccttttgag  atcttagta  gcactgtgg  gaagccatg  gtctgggct  agaggccac  1140
tttgaccac  tagtaagga  aaagcgggg  gggtggtgt  tccaggtta  tcatctgct  1200
tactgggct  tgaccaaaa  gggttttga  accacaatg  tgggaggat  tgtttacat  1260
actccagtc  acaaatata  cagtgaaat  gtccacctt  tagtacaag  gaccatcag  1320
gacaggaac  acattgtgg  ttctgccta  ggaagctcc  accagatgt  ggagcctct  1380
gaattaacc  cagggaagg  tcagcctca  gtgcctgcc  tctttcgtt  gacagaaga  1440
aatggaacc  ggtacttgg  ccaaatcag  agagagcag  atgttccaa  ccaagagtt  1500
gttaactcg  acctccttg  aaagagcaa  tatcgaaaa  tctattcct  tactcttga  1560
ccccgcact  ttgaggatt  tgaatatgt  aatacctac  ttcagacat  gccagcctc  1620
gtgtttgta  gcacatcgt  ctgttcctt  cagacctca  aaggggttt  ctgtttaat  1680
ggttccacc  ttacaagta  gagattcag  tataaggac  atgtagatc  ggttgagtt  1740
aagagtctg  ctgaggaag  aatagaaga  gtactgaaa  ccacatttg  catttcttt  1800
gagaaaaag  ttgtgccca  acatggcga  ctcgttttt  ctatttagg  taaattgtt  1860
tccattatt  tctcagtct  aaacattct  aaaatatgc  aatacatat  cataacaga  1920
atcgcacag  tcaatattg  tcaactaat  acctgtatc  tctatttcc  acattttat  1980
caaaacgaa  cccagttgt  ctgtcattt  accaataaa  ataccgcca  ttataatga  2040
ataaacctg  tcatggatg  aacgacaat  ctctcaaca  taatcaaca  aaattactt  2100
tcgaagagg  ggcgatctt  ggagccata  tcatttaca  acctcccaa  atcatttta  2160
ggttgaact  agatgaaaa  tgaatgaat  tgaatgatc  gagaacagc  ggaagtaaa  2220
tcaggcaga  taaatctga  gtccaaggt  tacaagaaa  cacctgtac  acttaggat  2280
agaataaag  aaagaagaa  gaaccatca  tacaggtcc  ggtaacttc  cagtcctca  2340
aacagaact  acgccagtg  acctgggct  tgggattag  tgccaagac  atgacacgg  2400
ttagaaggc  tagaatttc  tccagagat  attttgcag  cacagttct  tttgtatct  2460
atttttttt  actatgaga  tactggtat  aagtgattt  taccttata  ataataatc  2520
ttgtagcct  taa  2533



<210> 7928
<211> 290
<212> PRT
<213> Rattus norvegicus
<308> P50297
<400> 7928

Met Asp Ile Glu Ala Tyr Phe Glu Arg Ile Gly Tyr Lys Asn Ser Val 
  1               5                  10                  15
Asn Lys Leu Asp Leu Ala Thr Leu Thr Glu Val Leu Gln His Gln Met 
             20                  25                  30
Arg Ala Val Pro Phe Glu Asn Leu Ser Met His Cys Gly Glu Ala Met 
         35                  40                  45
Cys Leu Gly Leu Glu Ala Thr Phe Asp His Ile Val Arg Lys Lys Arg 
     50                  55                  60
Gly Gly Trp Cys Leu Gln Val Asn His Leu Leu Tyr Trp Ala Leu Thr 
 65                  70                  75                  80
Lys Met Gly Phe Glu Thr Thr Met Leu Gly Gly Tyr Val Tyr Ile Thr 
                 85                  90                  95
Pro Val Asn Lys Tyr Ser Ser Glu Met Val His Leu Leu Val Gln Val 
             100                105                110
Thr Ile Ser Asp Arg Asn Tyr Ile Val Asp Ser Ala Tyr Gly Ser Ser 
         115                120                125
Tyr Gln Met Trp Glu Pro Leu Glu Leu Thr Ser Gly Lys Asp Gln Pro 
     130                135                140
Gln Val Pro Ala Ile Phe Arg Leu Thr Glu Glu Asn Gly Thr Trp Tyr 
 145                150                155                160
Leu Asp Gln Ile Arg Arg Glu Gln Asp Val Pro Asn Gln Glu Phe Val 
                 165                170                175
Asn Ser Asp Leu Leu Glu Lys Ser Lys Tyr Arg Lys Ile Tyr Ser Phe 
             180                185                190
Thr Leu Glu Pro Arg Thr Ile Glu Asp Phe Glu Tyr Val Asn Thr Tyr 
         195                200                205
Leu Gln Thr Ser Pro Ala Ser Val Phe Val Ser Thr Ser Phe Cys Ser 
     210                215                220
Leu Gln Thr Ser Glu Gly Val Cys Cys Leu Ile Gly Ser Thr Leu Thr 
 225                230                235                240
Ser Arg Arg Phe Ser Tyr Lys Asp Asn Val Asp Leu Val Glu Phe Lys 
                 245                250                255
Ser Leu Thr Glu Glu Glu Ile Glu Asp Val Leu Lys Thr Thr Phe Gly 
             260                265                270
Ile Ser Leu Glu Lys Lys Phe Val Pro Lys His Gly Glu Leu Val Phe 
         275                280                285
Thr Ile 
     290



<210> 7929
<211> 1606
<212> DNA
<213> Homo sapiens
<308> U80835
<400> 7929

ctttgtata  ggctcagct  aaagggaaa  tgagtgggt  aggtaccac  gatactata  60
actctattg  atgattctc  tgcctacat  agaagatgt  tataagcct  ttttaaagg  120
taccagttg  aatctctct  ttattaatc  ccaagagaa  catgaacaa  ctgtttatc  180
tttgactca  catttaatc  tgatttcca  cttctcaca  ttgaaagaa  acataatac  240
tttctcaca  gattctggg  ctattaact  aacttatgt  tgtaaaagg  attcataca  300
tgaaagcac  agaaataat  attatactt  taaccattg  atttttaca  gtttaaaat  360
tagccataa  tagcctact  aaatccaag  gtaaaagta  tatgatttg  tttcgtttt  420
ttttccttg  ttaggggat  atggacatt  aagcatatc  tgaaagaat  ggctataag  480
agtctagga  caaattgga  ttggaaaca  taactgaca  tcttcaaca  cagatccga  540
ctgttccct  tgagaacct  aacatccat  gtggggatg  catggactt  ggcttagag  600
ccatttttg  tcaagttgt  agaagaaat  ggggtggat  gtgtctcca  gtcaatcat  660
ttctgtact  ggctctgac  actattggt  ttgagacca  gatgttggg  gggtatgtt  720
acagcactc  agccaaaaa  tacagcact  gcatgattc  ccttctcct  caggtgacc  780
ttgatggca  gaactacat  gtcgatgct  ggtttggac  ctcatacca  atgtggcag  840
ctctggagt  aatttctgg  aaggatcag  ctcaggtgc  ttgtatctt  cgtttgaca  900
aagagaatg  attctggta  ctagaccaa  tcagaaggg  acagtacat  ccaaatgaa  960
aatttcttc  ttctgatct  ctagaagac  gcaaatacc  aaaaatcta  tcctttact  1020
ttaagcctc  aacaattga  gattttgag  ctatgaata  atacctgca  acatctcca  1080
catctgtgt  tactagtaa  tcattttgt  ccttgcaga  cccagatgg  gttcactgt  1140
tggtgggct  caccctcac  cataggaga  tcaattata  ggacaatac  gatctaata  1200
agttcaaga  tctgagtga  gaagaaata  aaaaagtgc  gaaaaatat  tttaatatt  1260
ccttgcaga  aaagcttgt  cccaaacat  gtgatagat  ttttactat  tagaataag  1320
agtaaaaca  tcttgtcta  ttgtcatcc  gctcaccag  tatcaactg  cgacctatc  1380
tgtatcttc  gtaccctta  cttattttg  agaaaatcc  agacatcaa  tcatttcac  1440
tataaaaat  tcatcatat  taattaaac  gctttttaa  gaaacataa  cacaaacct  1500
ttcaaataa  aataataat  aatgtattt  aaagatggc  tgtggttat  ttggaaatt  1560
gtgatttat  ctagaaagc  tttaatgtt  gtttattgt  gaattc  1606



<210> 7930
<211> 291
<212> PRT
<213> Homo sapiens
<308> U80835
<400> 7930

Met Asp Ile Glu Ala Tyr Leu Glu Arg Ile Gly Tyr Lys Lys Ser Arg 
  1               5                  10                  15
Asn Lys Leu Asp Leu Glu Thr Leu Thr Asp Ile Leu Gln His Gln Ile 
             20                  25                  30
Arg Ala Val Pro Phe Glu Asn Leu Asn Ile His Cys Gly Asp Ala Met 
         35                  40                  45
Asp Leu Gly Leu Glu Ala Ile Phe Asp Gln Val Val Arg Arg Asn Arg 
     50                  55                  60
Gly Gly Trp Cys Leu Gln Val Asn His Leu Leu Tyr Trp Ala Leu Thr 
 65                  70                  75                  80
Thr Ile Gly Phe Glu Thr Thr Met Leu Gly Gly Tyr Val Tyr Ser Thr 
                 85                  90                  95
Pro Ala Lys Lys Tyr Ser Thr Gly Met Ile His Leu Leu Leu Gln Val 
             100                105                110
Thr Ile Asp Gly Arg Asn Tyr Ile Val Asp Ala Gly Phe Gly Arg Ser 
         115                120                125
Tyr Gln Met Trp Gln Pro Leu Glu Leu Ile Ser Gly Lys Asp Gln Pro 
     130                135                140
Gln Val Pro Cys Ile Phe Arg Leu Thr Glu Glu Asn Gly Phe Trp Tyr 
 145                150                155                160
Leu Asp Gln Ile Arg Arg Glu Gln Tyr Ile Pro Asn Glu Glu Phe Leu 
                 165                170                175
His Ser Asp Leu Leu Glu Asp Ser Lys Tyr Arg Lys Ile Tyr Ser Phe 
             180                185                190
Thr Leu Lys Pro Arg Thr Ile Glu Asp Phe Glu Ser Met Asn Thr Tyr 
         195                200                205
Leu Gln Thr Ser Pro Ala Ser Val Phe Thr Ser Lys Ser Phe Cys Ser 
     210                215                220
Leu Gln Thr Pro Asp Gly Val His Cys Leu Val Gly Phe Thr Leu Thr 
 225                230                235                240
His Arg Arg Phe Asn Tyr Lys Asp Asn Thr Asp Leu Ile Glu Phe Lys 
                 245                250                255
Thr Leu Ser Glu Glu Glu Ile Glu Lys Val Leu Lys Asn Ile Phe Asn 
             260                265                270
Ile Ser Leu Gln Arg Lys Leu Val Pro Lys His Gly Asp Arg Phe Phe 
         275                280                285
Thr Ile Ter 
     290



<210> 7931
<211> 1043
<212> DNA
<213> Rattus norvegicus
<308> U02315
<400> 7931

ggaagggca  gaagaagga  cggggatcc  gcgggaagc  cgggcccgc  gagggcgac  60
cgagcccag  actgcctcc  agattgaaa  aaatgaaga  ccaggagtc  gctgcaggc  120
ccaagctag  gctccggtg  gaaaccagc  ccgagtact  ctcactcag  ttcaaatgg  180
tcaagaatg  gaacgagct  aaccgcaaa  ataaaccag  aaacatcaa  atacagaag  240
agccaggga  gtcagagct  cgaattaac  aagcatccc  ggctgactc  ggagagtat  300
tgtgcaaag  gatcagcaa  ttaggaaat  acagtgcct  tgccaacat  accattgtt  360
agtcaaacg  gttcatcac  ggcatgcca  cctcgactg  gacagccta  gtgtcctca  420
agtctccca  tagaatctc  gtttcaaca  aaggcgcaa  cacttcttc  tccacatca  480
catccacga  tgggaccag  catctcata  agtgtgcgg  gaaggagaa  actttctgt  540
tgaatgggg  cgagtgctt  acggtgaag  acctgtcaa  cccgtcaag  tacttgtgc  600
agtgcccaa  tgagtttac  ggtgatcgt  gccaaaact  cgtaatggc  agcttctac  660
gtacgtcca  tccctttct  tctctgcct  agtaggagc  tgctcagtc  atgctgctt  720
cttgttgct  catctcccc  cagagtcac  tagagccta  aaccttcta  caggtctaa  780
attgactgc  tctgcctgt  gcatgagaa  attaacaag  ccgctgtgt  acttctctg  840
ttgtgacta  tcggctcag  gttactaaa  aggtgtgtg  ggccccaga  gtttctgaa  900
atggtcccg  agaaggtga  gcaaatcga  agtcaacat  ccaagagtg  aataataat  960
ataataata  taataataa  aataataat  aaggcgttt  aaactcgca  ttgtattgg  1020
aaaataaaa  cattccaac  agt  1043



<210> 7932
<211> 662
<212> PRT
<213> Rattus norvegicus
<308> P43322
<400> 7932

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
  1               5                  10                  15
Asp Arg Gly Ser Arg Gly Lys Pro Gly Pro Ala Glu Gly Asp Pro Ser 
             20                  25                  30
Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
         35                  40                  45
Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
     50                  55                  60
Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
 65                  70                  75                  80
Asn Lys Pro Glu Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                 85                  90                  95
Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
             100                105                110
Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
         115                120                125
Ile Val Glu Ser Asn Glu Phe Ile Thr Gly Met Pro Ala Ser Thr Glu 
     130                135                140
Thr Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
 145                150                155                160
Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                 165                170                175
Ser His Leu Ile Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
             180                185                190
Gly Gly Glu Cys Phe Thr Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
         195                200                205
Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
     210                215                220
Val Met Ala Ser Phe Tyr Met Thr Ser Arg Arg Lys Arg Gln Glu Thr 
 225                230                235                240
Glu Lys Pro Leu Glu Arg Lys Leu Asp His Ser Leu Val Lys Glu Ser 
                 245                250                255
Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile 
             260                265                270
Cys Ile Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys 
         275                280                285
Lys Thr Lys Lys Gln Arg Gln Lys Leu His Asp Arg Leu Arg Gln Ser 
     290                295                300
Leu Arg Ser Glu Arg Ser Asn Leu Val Asn Ile Ala Asn Gly Pro His 
 305                310                315                320
His Pro Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val 
                 325                330                335
Ser Lys Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Val Glu 
             340                345                350
Thr Ser Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr 
         355                360                365
Thr Val Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu 
     370                375                380
Ser Val Ile Ser Glu Ser Asn Ser Val Ile Met Met Ser Ser Val Glu 
 385                390                395                400
Asn Ser Arg His Ser Ser Pro Ala Gly Gly Pro Arg Gly Arg Leu His 
                 405                410                415
Gly Leu Gly Gly Pro Arg Asp Asn Ser Phe Leu Arg His Ala Arg Glu 
             420                425                430
Thr Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser 
         435                440                445
Ala Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro 
     450                455                460
Ser Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser 
 465                470                475                480
Met Thr Val Ser Met Pro Ser Val Ala Val Ser Pro Phe Val Glu Glu 
                 485                490                495
Glu Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys 
             500                505                510
Tyr Asp His His Pro Gln Gln Leu Asn Ser Phe His His Asn Pro Ala 
         515                520                525
His Gln Ser Thr Ser Leu Pro Pro Ser Pro Leu Arg Ile Val Glu Asp 
     530                535                540
Glu Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Ser Val Gln Glu Pro Val 
 545                550                555                560
Lys Lys Val Thr Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly 
                 565                570                575
His Ile Ala Asn Arg Leu Glu Met Asp Ser Asn Thr Ser Ser Val Ser 
             580                585                590
Ser Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr 
         595                600                605
Pro Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Val Ala 
     610                615                620
Pro Ala Phe Arg Leu Ala Glu Ser Arg Thr Asn Pro Ala Gly Arg Phe 
 625                630                635                640
Ser Thr Gln Glu Glu Leu Gln Ala Arg Leu Ser Ser Val Ile Ala Asn 
                 645                650                655
Gln Asp Pro Ile Ala Val 
             660



<210> 7933
<211> 886
<212> DNA
<213> Homo sapiens
<308> U02327
<400> 7933

gtgcctctg  caatatcac  atcgtggaa  caaacgaga  catcactgg  atgccagcc  60
caactgaag  agcatatgt  tcttcagag  ctcccatta  aatatcagt  tccacagaa  120
gagcaaata  ttcttcatc  acatctaca  ccaccactg  gacaagcca  cttgtaaaa  180
gtgcggaga  ggagaaaac  ttctgtgtg  atggagggg  gtgcttcat  gtgaaagac  240
tttcaaacc  ctcgagata  ttgtgcaag  gccaacctg  attcactgg  gcaagatgt  300
ctgagaatg  gcccatgaa  gtccaaaac  aagaaagtg  ccaaatgag  ttactggtg  360
tcgctgcca  aactacgta  tggccagct  ctacagtac  tccactccc  ttctgtctc  420
gcctgaata  gagcatgct  agttggtgc  gctttcttg  tgctgcatc  cccctcaga  480
tccacctag  gctagatgt  tcttaccag  tctaatatt  actgcctct  cctgtcgca  540
gagaacatt  acaaaagca  ttgtattac  tcctctgtt  gcgactagt  ggctctgag  600
tactaatag  tgtgtgagg  tccggatgt  tctggaatt  atattgaat  atgtgatac  660
aattgatag  caatatcaa  cagtgaaat  tgataataa  ggcatttca  agtctcact  720
ttattgata  aataaaaat  attctactg  acagtccat  ttctttata  aatgaccac  780
tcctgaaaa  ggtgttgct  agctgtaac  gatatgcac  tgaaatgat  gtaagttaa  840
tttgattca  aatgtgtta  ttgtcacaa  taaacataa  aaaagg  886



<210> 7934
<211> 639
<212> PRT
<213> Homo sapiens
<308> Q12784
<400> 7934

Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys Glu 
  1               5                  10                  15
Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser Pro 
             20                  25                  30
Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala 
         35                  40                  45
Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser 
     50                  55                  60
Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn 
 65                  70                  75                  80
Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu 
                 85                  90                  95
Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys 
             100                105                110
Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile 
         115                120                125
Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly 
     130                135                140
Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu 
 145                150                155                160
Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser 
                 165                170                175
His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly 
             180                185                190
Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu 
         195                200                205
Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn Val 
     210                215                220
Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln Lys 
 225                230                235                240
Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly 
                 245                250                255
Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys 
             260                265                270
Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met 
         275                280                285
Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn 
     290                295                300
Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu 
 305                310                315                320
His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr 
                 325                330                335
Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His 
             340                345                350
Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser 
         355                360                365
Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr 
     370                375                380
Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys 
 385                390                395                400
Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp 
                 405                410                415
Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg 
             420                425                430
Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro 
         435                440                445
Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser 
     450                455                460
Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val 
 465                470                475                480
Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln 
                 485                490                495
Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro 
             500                505                510
Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln 
         515                520                525
Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg 
     530                535                540
Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu 
 545                550                555                560
Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr 
                 565                570                575
Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn 
             580                585                590
Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp 
         595                600                605
Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln 
     610                615                620
Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
 625                630                635



<210> 7935
<211> 1043
<212> DNA
<213> Rattus norvegicus
<308> U02315
<400> 7935

ggaagggca  gaagaagga  cggggatcc  gcgggaagc  cgggcccgc  gagggcgac  60
cgagcccag  actgcctcc  agattgaaa  aaatgaaga  ccaggagtc  gctgcaggc  120
ccaagctag  gctccggtg  gaaaccagc  ccgagtact  ctcactcag  ttcaaatgg  180
tcaagaatg  gaacgagct  aaccgcaaa  ataaaccag  aaacatcaa  atacagaag  240
agccaggga  gtcagagct  cgaattaac  aagcatccc  ggctgactc  ggagagtat  300
tgtgcaaag  gatcagcaa  ttaggaaat  acagtgcct  tgccaacat  accattgtt  360
agtcaaacg  gttcatcac  ggcatgcca  cctcgactg  gacagccta  gtgtcctca  420
agtctccca  tagaatctc  gtttcaaca  aaggcgcaa  cacttcttc  tccacatca  480
catccacga  tgggaccag  catctcata  agtgtgcgg  gaaggagaa  actttctgt  540
tgaatgggg  cgagtgctt  acggtgaag  acctgtcaa  cccgtcaag  tacttgtgc  600
agtgcccaa  tgagtttac  ggtgatcgt  gccaaaact  cgtaatggc  agcttctac  660
gtacgtcca  tccctttct  tctctgcct  agtaggagc  tgctcagtc  atgctgctt  720
cttgttgct  catctcccc  cagagtcac  tagagccta  aaccttcta  caggtctaa  780
attgactgc  tctgcctgt  gcatgagaa  attaacaag  ccgctgtgt  acttctctg  840
ttgtgacta  tcggctcag  gttactaaa  aggtgtgtg  ggccccaga  gtttctgaa  900
atggtcccg  agaaggtga  gcaaatcga  agtcaacat  ccaagagtg  aataataat  960
ataataata  taataataa  aataataat  aaggcgttt  aaactcgca  ttgtattgg  1020
aaaataaaa  cattccaac  agt  1043



<210> 7936
<211> 662
<212> PRT
<213> Rattus norvegicus
<308> P43322
<400> 7936

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
  1               5                  10                  15
Asp Arg Gly Ser Arg Gly Lys Pro Gly Pro Ala Glu Gly Asp Pro Ser 
             20                  25                  30
Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
         35                  40                  45
Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
     50                  55                  60
Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
 65                  70                  75                  80
Asn Lys Pro Glu Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                 85                  90                  95
Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
             100                105                110
Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
         115                120                125
Ile Val Glu Ser Asn Glu Phe Ile Thr Gly Met Pro Ala Ser Thr Glu 
     130                135                140
Thr Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
 145                150                155                160
Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                 165                170                175
Ser His Leu Ile Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
             180                185                190
Gly Gly Glu Cys Phe Thr Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
         195                200                205
Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
     210                215                220
Val Met Ala Ser Phe Tyr Met Thr Ser Arg Arg Lys Arg Gln Glu Thr 
 225                230                235                240
Glu Lys Pro Leu Glu Arg Lys Leu Asp His Ser Leu Val Lys Glu Ser 
                 245                250                255
Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile 
             260                265                270
Cys Ile Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys 
         275                280                285
Lys Thr Lys Lys Gln Arg Gln Lys Leu His Asp Arg Leu Arg Gln Ser 
     290                295                300
Leu Arg Ser Glu Arg Ser Asn Leu Val Asn Ile Ala Asn Gly Pro His 
 305                310                315                320
His Pro Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val 
                 325                330                335
Ser Lys Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Val Glu 
             340                345                350
Thr Ser Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr 
         355                360                365
Thr Val Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu 
     370                375                380
Ser Val Ile Ser Glu Ser Asn Ser Val Ile Met Met Ser Ser Val Glu 
 385                390                395                400
Asn Ser Arg His Ser Ser Pro Ala Gly Gly Pro Arg Gly Arg Leu His 
                 405                410                415
Gly Leu Gly Gly Pro Arg Asp Asn Ser Phe Leu Arg His Ala Arg Glu 
             420                425                430
Thr Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser 
         435                440                445
Ala Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro 
     450                455                460
Ser Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser 
 465                470                475                480
Met Thr Val Ser Met Pro Ser Val Ala Val Ser Pro Phe Val Glu Glu 
                 485                490                495
Glu Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys 
             500                505                510
Tyr Asp His His Pro Gln Gln Leu Asn Ser Phe His His Asn Pro Ala 
         515                520                525
His Gln Ser Thr Ser Leu Pro Pro Ser Pro Leu Arg Ile Val Glu Asp 
     530                535                540
Glu Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Ser Val Gln Glu Pro Val 
 545                550                555                560
Lys Lys Val Thr Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly 
                 565                570                575
His Ile Ala Asn Arg Leu Glu Met Asp Ser Asn Thr Ser Ser Val Ser 
             580                585                590
Ser Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr 
         595                600                605
Pro Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Val Ala 
     610                615                620
Pro Ala Phe Arg Leu Ala Glu Ser Arg Thr Asn Pro Ala Gly Arg Phe 
 625                630                635                640
Ser Thr Gln Glu Glu Leu Gln Ala Arg Leu Ser Ser Val Ile Ala Asn 
                 645                650                655
Gln Asp Pro Ile Ala Val 
             660



<210> 7937
<211> 886
<212> DNA
<213> Homo sapiens
<308> U02327
<400> 7937

gtgcctctg  caatatcac  atcgtggaa  caaacgaga  catcactgg  atgccagcc  60
caactgaag  agcatatgt  tcttcagag  ctcccatta  aatatcagt  tccacagaa  120
gagcaaata  ttcttcatc  acatctaca  ccaccactg  gacaagcca  cttgtaaaa  180
gtgcggaga  ggagaaaac  ttctgtgtg  atggagggg  gtgcttcat  gtgaaagac  240
tttcaaacc  ctcgagata  ttgtgcaag  gccaacctg  attcactgg  gcaagatgt  300
ctgagaatg  gcccatgaa  gtccaaaac  aagaaagtg  ccaaatgag  ttactggtg  360
tcgctgcca  aactacgta  tggccagct  ctacagtac  tccactccc  ttctgtctc  420
gcctgaata  gagcatgct  agttggtgc  gctttcttg  tgctgcatc  cccctcaga  480
tccacctag  gctagatgt  tcttaccag  tctaatatt  actgcctct  cctgtcgca  540
gagaacatt  acaaaagca  ttgtattac  tcctctgtt  gcgactagt  ggctctgag  600
tactaatag  tgtgtgagg  tccggatgt  tctggaatt  atattgaat  atgtgatac  660
aattgatag  caatatcaa  cagtgaaat  tgataataa  ggcatttca  agtctcact  720
ttattgata  aataaaaat  attctactg  acagtccat  ttctttata  aatgaccac  780
tcctgaaaa  ggtgttgct  agctgtaac  gatatgcac  tgaaatgat  gtaagttaa  840
tttgattca  aatgtgtta  ttgtcacaa  taaacataa  aaaagg  886



<210> 7938
<211> 639
<212> PRT
<213> Homo sapiens
<308> Q12784
<400> 7938

Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys Glu 
  1               5                  10                  15
Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser Pro 
             20                  25                  30
Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala 
         35                  40                  45
Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser 
     50                  55                  60
Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn 
 65                  70                  75                  80
Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu 
                 85                  90                  95
Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys 
             100                105                110
Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile 
         115                120                125
Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly 
     130                135                140
Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu 
 145                150                155                160
Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser 
                 165                170                175
His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly 
             180                185                190
Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu 
         195                200                205
Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn Val 
     210                215                220
Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln Lys 
 225                230                235                240
Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly 
                 245                250                255
Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys 
             260                265                270
Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met 
         275                280                285
Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn 
     290                295                300
Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu 
 305                310                315                320
His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr 
                 325                330                335
Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His 
             340                345                350
Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser 
         355                360                365
Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr 
     370                375                380
Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys 
 385                390                395                400
Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp 
                 405                410                415
Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg 
             420                425                430
Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro 
         435                440                445
Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser 
     450                455                460
Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val 
 465                470                475                480
Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln 
                 485                490                495
Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro 
             500                505                510
Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln 
         515                520                525
Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg 
     530                535                540
Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu 
 545                550                555                560
Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr 
                 565                570                575
Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn 
             580                585                590
Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp 
         595                600                605
Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln 
     610                615                620
Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
 625                630                635



<210> 7939
<211> 1255
<212> DNA
<213> Rattus norvegicus
<308> U02320
<400> 7939

gcggccgca  ctgccggga  atgcgagcg  agaccggat  gtgatcacc  ttccctctt  60
gggctgtaa  agagcgaga  aagccaccg  agcgaggcc  ctccagagc  ggcagcgga  120
ggacccggg  cactagagc  gctccgagc  actccagac  gagcggacg  tccaggtga  180
cgagtccac  ctgcttcct  caggcgaca  gcgacgcct  ccgagcagc  cggccactg  240
ctcttcccc  cctgggaca  acttttctg  aagcccttg  accaaactt  tcgcgcgtc  300
ccgtcaccc  accgggtcc  cgtagagcg  tcatcttcg  cgagatgtc  gagcgcaaa  360
aaggcagag  caaggggaa  ggcaagaag  aggaccggg  atcccgcgg  aagcccggg  420
ccgccgagg  cgacccgag  ccagcactg  ctcccagat  gaaagaaat  aagagccag  480
agtcagctg  aggctccaa  ctagtgctc  ggtgcgaaa  cagctccga  tactcctca  540
tcagattca  atggttcaa  aatgggaac  agctgaacc  caaaaataa  ccagaaaac  600
tcaagatac  gaagaagcc  gggaagtca  agcttcgaa  taacaaagc  tccctggct  660
actctggag  gtatatgtg  aaagtgatc  gcaagttag  aaatgacag  gcctctgcc  720
acatcacca  tgttgagtc  aacgagttc  tcactggca  gccagcctc  actgagaca  780
cctatgtgt  ctcagagtc  cccattaga  tctcagttt  aacagaagg  gcaaacact  840
cttcatcca  atcaacatc  acgactggg  ccagccatc  cataaagtg  gcggagaag  900
agaaaactt  ctgtgtgaa  gggggcgag  gcttcacgg  gaaggacct  tcaaacccg  960
caagatact  gtgcaagtg  ccaaatgag  ttactggtg  tcgttgcca  aactacgta  1020
tggccagct  ctacaaagc  gaggaactc  accagaaga  ggtgctgac  attactggc  1080
tctgtatcg  cctgctggt  gtcggcatc  tgtgtgtgg  ggcctactg  aaaaccaag  1140
agcagcggc  gaagcttca  gatcggctt  ggcagagtc  tcggtcaga  cggagcaac  1200
tggtgaaca  agcgaatgg  cctcaccac  caaacccac  cgtccggac  cgtgg  1255



<210> 7940
<211> 662
<212> PRT
<213> Rattus norvegicus
<308> AAA19945
<400> 7940

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
  1               5                  10                  15
Asp Arg Gly Ser Arg Gly Lys Pro Gly Pro Ala Glu Gly Asp Pro Ser 
             20                  25                  30
Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
         35                  40                  45
Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
     50                  55                  60
Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
 65                  70                  75                  80
Asn Lys Pro Glu Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                 85                  90                  95
Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
             100                105                110
Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
         115                120                125
Ile Val Glu Ser Asn Glu Phe Ile Thr Gly Met Pro Ala Ser Thr Glu 
     130                135                140
Thr Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
 145                150                155                160
Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                 165                170                175
Ser His Leu Ile Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
             180                185                190
Gly Gly Glu Cys Phe Thr Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
         195                200                205
Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
     210                215                220
Val Met Ala Ser Phe Tyr Met Thr Ser Arg Arg Lys Arg Gln Glu Thr 
 225                230                235                240
Glu Lys Pro Leu Glu Arg Lys Leu Asp His Ser Leu Val Lys Glu Ser 
                 245                250                255
Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile 
             260                265                270
Cys Ile Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys 
         275                280                285
Lys Thr Lys Lys Gln Arg Gln Lys Leu His Asp Arg Leu Arg Gln Ser 
     290                295                300
Leu Arg Ser Glu Arg Ser Asn Leu Val Asn Ile Ala Asn Gly Pro His 
 305                310                315                320
His Pro Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val 
                 325                330                335
Ser Lys Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Val Glu 
             340                345                350
Thr Ser Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr 
         355                360                365
Thr Val Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu 
     370                375                380
Ser Val Ile Ser Glu Ser Asn Ser Val Ile Met Met Ser Ser Val Glu 
 385                390                395                400
Asn Ser Arg His Ser Ser Pro Ala Gly Gly Pro Arg Gly Arg Leu His 
                 405                410                415
Gly Leu Gly Gly Pro Arg Asp Asn Ser Phe Leu Arg His Ala Arg Glu 
             420                425                430
Thr Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser 
         435                440                445
Ala Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro 
     450                455                460
Ser Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser 
 465                470                475                480
Met Thr Val Ser Met Pro Ser Val Ala Val Ser Pro Phe Val Glu Glu 
                 485                490                495
Glu Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys 
             500                505                510
Tyr Asp His His Pro Gln Gln Leu Asn Ser Phe His His Asn Pro Ala 
         515                520                525
His Gln Ser Thr Ser Leu Pro Pro Ser Pro Leu Arg Ile Val Glu Asp 
     530                535                540
Glu Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Ser Val Gln Glu Pro Val 
 545                550                555                560
Lys Lys Val Thr Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly 
                 565                570                575
His Ile Ala Asn Arg Leu Glu Met Asp Ser Asn Thr Ser Ser Val Ser 
             580                585                590
Ser Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr 
         595                600                605
Pro Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Val Ala 
     610                615                620
Pro Ala Phe Arg Leu Ala Glu Ser Arg Thr Asn Pro Ala Gly Arg Phe 
 625                630                635                640
Ser Thr Gln Glu Glu Leu Gln Ala Arg Leu Ser Ser Val Ile Ala Asn 
                 645                650                655
Gln Asp Pro Ile Ala Val 
             660



<210> 7941
<211> 2490
<212> DNA
<213> Homo sapiens
<308> NM_013957
<400> 7941

gtggctgcg  ggcaattga  aaagagccg  cgaggagtt  cccgaaact  gttggaact  60
cgggctcgc  cggaggcca  gagctgagc  gcggcggct  ccggacgat  ggagcgtga  120
caggacggt  ataacctct  cccgatcgg  ttgcgaggg  gccgggcag  ggccaggac  180
cgagccgcc  gcggcggga  ccatcgacg  cttcccggg  cgacaggag  agccccgag  240
gccagggcg  gcgcccgtt  caggtggcc  gaccgcccg  cgcgtccgc  ccgcgctcc  300
tgcaggcaa  gggagacgc  cccgcgcag  gcgagcgcc  cagcgcggc  gctcgctct  360
cccatcgag  gacaaactt  tcccaaacc  gatccgagc  cttggacca  actcgcctg  420
gccgagagc  gtccgcgta  agcgctccg  ctccggcga  atgtccgag  gcaaagaag  480
cagaggcaa  gggaagggc  agaagaagg  gcgaggctc  ggcaagaag  cggagtccg  540
ggcgggcag  cagagccca  ccttgcctc  ccaattgaa  gagatgaaa  gccaggaat  600
ggctgcagg  tccaaacta  tccttcggt  tgaaaccag  tctgaatac  cctctctca  660
attcaagtg  ttcaagaat  ggaatgaat  gaatcgaaa  aacaaacca  aaaatatca  720
gatacaaaa  aagccaggg  agtcagaac  tcgcattaa  aaagcatca  tggctgatt  780
tggagagta  atgtgcaaa  tgatcagca  attaggaaa  gacagtgcc  ctgccaata  840
caccatcgt  gaatcaaac  agatcatca  tggtatgcc  gcctcaact  aaggagcat  900
tgtgtcttc  gagtctccc  ttagaatat  agtatccac  gaaggagca  atacttctt  960
atctacatc  acatccacc  ctgggacaa  ccatcttgt  aaatgtgcg  agaaggaga  1020
aactttctg  gtgaatgga  gggagtgct  catggtgaa  gacctttca  acccctcga  1080
atacttgtg  aagtgccca  atgagttta  tggtgatcg  tgccaaaac  acgtaatgg  1140
cagcttcta  aaggcggag  agctgtacc  gaagagagt  ctgaccata  ccggcatct  1200
catcgccct  cttgtggtc  gcatcatgt  tgtggtggc  tactgcaaa  ccaagaaac  1260
gcggaaaaa  ctgcatgac  gtcttcggc  gagccttcg  tctgaacga  acaatatga  1320
gaacattgc  aatgggcct  accatccta  cccaccccc  gagaatgtc  agctggtga  1380
tcaatacgt  tctaaaaac  tcatctcca  tgagcatat  gttgagaga  aagcagaga  1440
atccttttc  accagtcac  atacttcca  agcccatca  tccactact  tcacccaga  1500
tcctagcca  agctggagc  acggacaca  tgaaagcat  ctttccgaa  gccactctg  1560
aatcgtgat  tcatccgta  aaaacagta  gcacagcag  ccaactggg  gcccaagag  1620
acgtcttaa  ggcacagga  gccctcgtg  atgtaacag  ttcctcagg  atgccagag  1680
aacccctga  tcctaccga  actctcctc  tagtgaaag  tatgtgtca  ccatgacca  1740
cccggctcg  atgtcacct  tagatttcc  cacgccaag  tcccccaaa  cgccccctt  1800
ggaaatgtc  ccacccgtg  ccagcatga  ggtgtccaa  ccttccatg  cggtcagcc  1860
cttcatgga  gaagagaga  ctctacttc  cgtgacacc  ccaaggctg  gggagaaga  1920
gtttgacca  caccctcag  agttcagct  cttccacca  aaccccgcg  atgacagta  1980
cagcctccc  gctagcccc  tgaggatag  ggaggatga  gagtatgaa  cgacccaag  2040
gtacgagcc  gcccaagag  ctgttaaga  actcgccaa  agccggcgg  ccaaaagaa  2100
caagcccaa  ggccacatt  ctaacagat  ggaagtgga  agcaacaca  gctcccaga  2160
cagtaactc  gagagtgaa  cagaagatg  aagagtagg  gaagatacg  ctttcctgg  2220
catacagaa  cccctggca  ccagtcttg  ggcaacacc  gccttccgc  tggctgaca  2280
caggactaa  ccagcaggc  gcttctcga  acaggaaga  atccaggcc  ggctgtcta  2340
tgtaattgc  aaccaagac  ctattgctg  ataaaacct  aataaacac  tagattcac  2400
tgtaaaact  tattttata  aataaagta  tccacctta  attaaacaa  ttattttat  2460
ttagcagtt  tgcaaataa  aaaaaaaaaa  2490



<210> 7942
<211> 639
<212> PRT
<213> Homo sapiens
<308> Q12784
<400> 7942

Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys Glu 
  1               5                  10                  15
Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser Pro 
             20                  25                  30
Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala 
         35                  40                  45
Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser 
     50                  55                  60
Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn 
 65                  70                  75                  80
Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu 
                 85                  90                  95
Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys 
             100                105                110
Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile 
         115                120                125
Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly 
     130                135                140
Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu 
 145                150                155                160
Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser 
                 165                170                175
His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly 
             180                185                190
Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu 
         195                200                205
Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn Val 
     210                215                220
Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln Lys 
 225                230                235                240
Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly 
                 245                250                255
Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys 
             260                265                270
Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met 
         275                280                285
Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn 
     290                295                300
Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu 
 305                310                315                320
His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr 
                 325                330                335
Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His 
             340                345                350
Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser 
         355                360                365
Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr 
     370                375                380
Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys 
 385                390                395                400
Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp 
                 405                410                415
Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg 
             420                425                430
Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro 
         435                440                445
Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser 
     450                455                460
Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val 
 465                470                475                480
Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln 
                 485                490                495
Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro 
             500                505                510
Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln 
         515                520                525
Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg 
     530                535                540
Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu 
 545                550                555                560
Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr 
                 565                570                575
Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn 
             580                585                590
Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp 
         595                600                605
Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln 
     610                615                620
Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
 625                630                635



<210> 7943
<211> 1255
<212> DNA
<213> Rattus norvegicus
<308> U02320
<400> 7943

gcggccgca  ctgccggga  atgcgagcg  agaccggat  gtgatcacc  ttccctctt  60
gggctgtaa  agagcgaga  aagccaccg  agcgaggcc  ctccagagc  ggcagcgga  120
ggacccggg  cactagagc  gctccgagc  actccagac  gagcggacg  tccaggtga  180
cgagtccac  ctgcttcct  caggcgaca  gcgacgcct  ccgagcagc  cggccactg  240
ctcttcccc  cctgggaca  acttttctg  aagcccttg  accaaactt  tcgcgcgtc  300
ccgtcaccc  accgggtcc  cgtagagcg  tcatcttcg  cgagatgtc  gagcgcaaa  360
aaggcagag  caaggggaa  ggcaagaag  aggaccggg  atcccgcgg  aagcccggg  420
ccgccgagg  cgacccgag  ccagcactg  ctcccagat  gaaagaaat  aagagccag  480
agtcagctg  aggctccaa  ctagtgctc  ggtgcgaaa  cagctccga  tactcctca  540
tcagattca  atggttcaa  aatgggaac  agctgaacc  caaaaataa  ccagaaaac  600
tcaagatac  gaagaagcc  gggaagtca  agcttcgaa  taacaaagc  tccctggct  660
actctggag  gtatatgtg  aaagtgatc  gcaagttag  aaatgacag  gcctctgcc  720
acatcacca  tgttgagtc  aacgagttc  tcactggca  gccagcctc  actgagaca  780
cctatgtgt  ctcagagtc  cccattaga  tctcagttt  aacagaagg  gcaaacact  840
cttcatcca  atcaacatc  acgactggg  ccagccatc  cataaagtg  gcggagaag  900
agaaaactt  ctgtgtgaa  gggggcgag  gcttcacgg  gaaggacct  tcaaacccg  960
caagatact  gtgcaagtg  ccaaatgag  ttactggtg  tcgttgcca  aactacgta  1020
tggccagct  ctacaaagc  gaggaactc  accagaaga  ggtgctgac  attactggc  1080
tctgtatcg  cctgctggt  gtcggcatc  tgtgtgtgg  ggcctactg  aaaaccaag  1140
agcagcggc  gaagcttca  gatcggctt  ggcagagtc  tcggtcaga  cggagcaac  1200
tggtgaaca  agcgaatgg  cctcaccac  caaacccac  cgtccggac  cgtgg  1255



<210> 7944
<211> 662
<212> PRT
<213> Rattus norvegicus
<308> AAA19945
<400> 7944

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
  1               5                  10                  15
Asp Arg Gly Ser Arg Gly Lys Pro Gly Pro Ala Glu Gly Asp Pro Ser 
             20                  25                  30
Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
         35                  40                  45
Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
     50                  55                  60
Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
 65                  70                  75                  80
Asn Lys Pro Glu Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                 85                  90                  95
Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
             100                105                110
Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
         115                120                125
Ile Val Glu Ser Asn Glu Phe Ile Thr Gly Met Pro Ala Ser Thr Glu 
     130                135                140
Thr Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
 145                150                155                160
Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                 165                170                175
Ser His Leu Ile Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
             180                185                190
Gly Gly Glu Cys Phe Thr Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
         195                200                205
Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
     210                215                220
Val Met Ala Ser Phe Tyr Met Thr Ser Arg Arg Lys Arg Gln Glu Thr 
 225                230                235                240
Glu Lys Pro Leu Glu Arg Lys Leu Asp His Ser Leu Val Lys Glu Ser 
                 245                250                255
Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile 
             260                265                270
Cys Ile Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys 
         275                280                285
Lys Thr Lys Lys Gln Arg Gln Lys Leu His Asp Arg Leu Arg Gln Ser 
     290                295                300
Leu Arg Ser Glu Arg Ser Asn Leu Val Asn Ile Ala Asn Gly Pro His 
 305                310                315                320
His Pro Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val 
                 325                330                335
Ser Lys Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Val Glu 
             340                345                350
Thr Ser Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr 
         355                360                365
Thr Val Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu 
     370                375                380
Ser Val Ile Ser Glu Ser Asn Ser Val Ile Met Met Ser Ser Val Glu 
 385                390                395                400
Asn Ser Arg His Ser Ser Pro Ala Gly Gly Pro Arg Gly Arg Leu His 
                 405                410                415
Gly Leu Gly Gly Pro Arg Asp Asn Ser Phe Leu Arg His Ala Arg Glu 
             420                425                430
Thr Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser 
         435                440                445
Ala Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro 
     450                455                460
Ser Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser 
 465                470                475                480
Met Thr Val Ser Met Pro Ser Val Ala Val Ser Pro Phe Val Glu Glu 
                 485                490                495
Glu Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys 
             500                505                510
Tyr Asp His His Pro Gln Gln Leu Asn Ser Phe His His Asn Pro Ala 
         515                520                525
His Gln Ser Thr Ser Leu Pro Pro Ser Pro Leu Arg Ile Val Glu Asp 
     530                535                540
Glu Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Ser Val Gln Glu Pro Val 
 545                550                555                560
Lys Lys Val Thr Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly 
                 565                570                575
His Ile Ala Asn Arg Leu Glu Met Asp Ser Asn Thr Ser Ser Val Ser 
             580                585                590
Ser Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr 
         595                600                605
Pro Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Val Ala 
     610                615                620
Pro Ala Phe Arg Leu Ala Glu Ser Arg Thr Asn Pro Ala Gly Arg Phe 
 625                630                635                640
Ser Thr Gln Glu Glu Leu Gln Ala Arg Leu Ser Ser Val Ile Ala Asn 
                 645                650                655
Gln Asp Pro Ile Ala Val 
             660



<210> 7945
<211> 2490
<212> DNA
<213> Homo sapiens
<308> NM_013957
<400> 7945

gtggctgcg  ggcaattga  aaagagccg  cgaggagtt  cccgaaact  gttggaact  60
cgggctcgc  cggaggcca  gagctgagc  gcggcggct  ccggacgat  ggagcgtga  120
caggacggt  ataacctct  cccgatcgg  ttgcgaggg  gccgggcag  ggccaggac  180
cgagccgcc  gcggcggga  ccatcgacg  cttcccggg  cgacaggag  agccccgag  240
gccagggcg  gcgcccgtt  caggtggcc  gaccgcccg  cgcgtccgc  ccgcgctcc  300
tgcaggcaa  gggagacgc  cccgcgcag  gcgagcgcc  cagcgcggc  gctcgctct  360
cccatcgag  gacaaactt  tcccaaacc  gatccgagc  cttggacca  actcgcctg  420
gccgagagc  gtccgcgta  agcgctccg  ctccggcga  atgtccgag  gcaaagaag  480
cagaggcaa  gggaagggc  agaagaagg  gcgaggctc  ggcaagaag  cggagtccg  540
ggcgggcag  cagagccca  ccttgcctc  ccaattgaa  gagatgaaa  gccaggaat  600
ggctgcagg  tccaaacta  tccttcggt  tgaaaccag  tctgaatac  cctctctca  660
attcaagtg  ttcaagaat  ggaatgaat  gaatcgaaa  aacaaacca  aaaatatca  720
gatacaaaa  aagccaggg  agtcagaac  tcgcattaa  aaagcatca  tggctgatt  780
tggagagta  atgtgcaaa  tgatcagca  attaggaaa  gacagtgcc  ctgccaata  840
caccatcgt  gaatcaaac  agatcatca  tggtatgcc  gcctcaact  aaggagcat  900
tgtgtcttc  gagtctccc  ttagaatat  agtatccac  gaaggagca  atacttctt  960
atctacatc  acatccacc  ctgggacaa  ccatcttgt  aaatgtgcg  agaaggaga  1020
aactttctg  gtgaatgga  gggagtgct  catggtgaa  gacctttca  acccctcga  1080
atacttgtg  aagtgccca  atgagttta  tggtgatcg  tgccaaaac  acgtaatgg  1140
cagcttcta  aaggcggag  agctgtacc  gaagagagt  ctgaccata  ccggcatct  1200
catcgccct  cttgtggtc  gcatcatgt  tgtggtggc  tactgcaaa  ccaagaaac  1260
gcggaaaaa  ctgcatgac  gtcttcggc  gagccttcg  tctgaacga  acaatatga  1320
gaacattgc  aatgggcct  accatccta  cccaccccc  gagaatgtc  agctggtga  1380
tcaatacgt  tctaaaaac  tcatctcca  tgagcatat  gttgagaga  aagcagaga  1440
atccttttc  accagtcac  atacttcca  agcccatca  tccactact  tcacccaga  1500
tcctagcca  agctggagc  acggacaca  tgaaagcat  ctttccgaa  gccactctg  1560
aatcgtgat  tcatccgta  aaaacagta  gcacagcag  ccaactggg  gcccaagag  1620
acgtcttaa  ggcacagga  gccctcgtg  atgtaacag  ttcctcagg  atgccagag  1680
aacccctga  tcctaccga  actctcctc  tagtgaaag  tatgtgtca  ccatgacca  1740
cccggctcg  atgtcacct  tagatttcc  cacgccaag  tcccccaaa  cgccccctt  1800
ggaaatgtc  ccacccgtg  ccagcatga  ggtgtccaa  ccttccatg  cggtcagcc  1860
cttcatgga  gaagagaga  ctctacttc  cgtgacacc  ccaaggctg  gggagaaga  1920
gtttgacca  caccctcag  agttcagct  cttccacca  aaccccgcg  atgacagta  1980
cagcctccc  gctagcccc  tgaggatag  ggaggatga  gagtatgaa  cgacccaag  2040
gtacgagcc  gcccaagag  ctgttaaga  actcgccaa  agccggcgg  ccaaaagaa  2100
caagcccaa  ggccacatt  ctaacagat  ggaagtgga  agcaacaca  gctcccaga  2160
cagtaactc  gagagtgaa  cagaagatg  aagagtagg  gaagatacg  ctttcctgg  2220
catacagaa  cccctggca  ccagtcttg  ggcaacacc  gccttccgc  tggctgaca  2280
caggactaa  ccagcaggc  gcttctcga  acaggaaga  atccaggcc  ggctgtcta  2340
tgtaattgc  aaccaagac  ctattgctg  ataaaacct  aataaacac  tagattcac  2400
tgtaaaact  tattttata  aataaagta  tccacctta  attaaacaa  ttattttat  2460
ttagcagtt  tgcaaataa  aaaaaaaaaa  2490



<210> 7946
<211> 639
<212> PRT
<213> Homo sapiens
<308> Q12784
<400> 7946

Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys Glu 
  1               5                  10                  15
Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser Pro 
             20                  25                  30
Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala 
         35                  40                  45
Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser 
     50                  55                  60
Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn 
 65                  70                  75                  80
Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu 
                 85                  90                  95
Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys 
             100                105                110
Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile 
         115                120                125
Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly 
     130                135                140
Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu 
 145                150                155                160
Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser 
                 165                170                175
His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly 
             180                185                190
Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu 
         195                200                205
Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn Val 
     210                215                220
Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln Lys 
 225                230                235                240
Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly 
                 245                250                255
Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys 
             260                265                270
Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met 
         275                280                285
Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn 
     290                295                300
Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu 
 305                310                315                320
His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr 
                 325                330                335
Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His 
             340                345                350
Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser 
         355                360                365
Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr 
     370                375                380
Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys 
 385                390                395                400
Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp 
                 405                410                415
Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg 
             420                425                430
Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro 
         435                440                445
Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser 
     450                455                460
Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val 
 465                470                475                480
Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln 
                 485                490                495
Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro 
             500                505                510
Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln 
         515                520                525
Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg 
     530                535                540
Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu 
 545                550                555                560
Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr 
                 565                570                575
Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn 
             580                585                590
Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp 
         595                600                605
Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln 
     610                615                620
Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
 625                630                635



<210> 7947
<211> 2402
<212> DNA
<213> Rattus norvegicus
<308> U02322
<400> 7947

gcggccgca  ctgccggga  atgcgagcg  agaccggat  gtgatcacc  ttccctctt  60
gggctgtaa  agagcgaga  aagccaccg  agcgaggcc  ctccagagc  ggcagcgga  120
ggacccggg  cactagagc  gctccgagc  actccagac  gagcggacg  tccaggtga  180
cgagtccac  ctgcttcct  caggcgaca  gcgacgcct  ccgagcagc  cggccactg  240
ctcttcccc  cctgggaca  acttttctg  aagcccttg  accaaactt  tcgcgcgtc  300
ccgtcaccc  accgggtcc  cgtagagcg  tcatcttcg  cgagatgtc  gagcgcaaa  360
aaggcagag  caaggggaa  ggcaagaag  aggaccggg  atcccgcgg  aagcccggg  420
ccgccgagg  cgacccgag  ccagcactg  ctcccagat  gaaagaaat  aagagccag  480
agtcagctg  aggctccaa  ctagtgctc  ggtgcgaaa  cagctccga  tactcctca  540
tcagattca  atggttcaa  aatgggaac  agctgaacc  caaaaataa  ccagaaaac  600
tcaagatac  gaagaagcc  gggaagtca  agcttcgaa  taacaaagc  tccctggct  660
actctggag  gtatatgtg  aaagtgatc  gcaagttag  aaatgacag  gcctctgcc  720
acatcacca  tgttgagtc  aacgagttc  tcactggca  gccagcctc  actgagaca  780
cctatgtgt  ctcagagtc  cccattaga  tctcagttt  aacagaagg  gcaaacact  840
cttcatcca  atcaacatc  acgactggg  ccagccatc  cataaagtg  gcggagaag  900
agaaaactt  ctgtgtgaa  gggggcgag  gcttcacgg  gaaggacct  tcaaacccg  960
caagatact  gtgcaagtg  ccaaatgag  ttactggtg  tcgttgcca  aactacgta  1020
tggccagct  ctacatgac  tctaggagg  aaaggcaag  aacagagaa  cctctagaa  1080
gaaaattgg  tcatagcct  gtgaaagaa  cgaaagcgg  ggaactcta  cagaagagg  1140
tgctgacaa  tactggcat  tgtatcgcc  tgctggtgg  cggcatcat  tgtgtggtg  1200
cctactgca  aaccaagaa  cagcggcag  agcttcatg  tcggcttcg  cagagtctt  1260
ggtcagaac  gagcaacct  gtgaacata  cgaatgggc  tcaccaccc  aacccaccg  1320
cagagaacg  gcagctggt  aatcaatac  tatctaaaa  cgtcatctc  agtgagcat  1380
ttgttgaga  agaagtgga  acttccttt  ccaccagtc  ttacacttc  acagcccat  1440
actccacga  tgtcaccca  actcctagt  acagctgga  taatgggca  acggagagc  1500
tcatttcag  aagcaactc  gtaatcatg  tgtcttcgg  agagaacag  aggcacagc  1560
gtcccgccg  gggcccacg  ggacgtctt  atggcctgg  aggccctcg  gataacagc  1620
tcctcaggc  tgccagaga  acccctgac  cctacagag  ctctcctca  agcgaaagg  1680
atgtatcag  catgaccac  ccggctcgt  tgtcacctg  agatttcca  acgccaagc  1740
cccctaaat  gcccccttc  gaaatgtct  cacccgtgt  cagcatgac  gtgtccatg  1800
cctctgtgg  agtcagccc  tttgtggaa  aagagaggc  tctgctgct  gtgacgcca  1860
caaggctac  ggagaagaa  tatgatcat  acccccagc  actcaactc  tttcatcac  1920
accctgcac  tcagagtac  agcctcccc  ctagcccac  gaggatagt  gaggatgag  1980
agtacgaga  gacccagga  tatgagtca  ttcaagagc  cgttaagaa  gtcaccaat  2040
gccggcggg  caaaagaac  aagcccaat  gccacattg  caataggtt  gaaatggac  2100
gcaacacaa  ttctgtgag  agtaactca  aaagtgaga  agaagacga  agagtaggt  2160
aagacacac  attcctggg  atacagaac  ccctggcag  cagccttga  gtggcccct  2220
ccttccgtc  ggctgagag  aggactaac  cagcaggcc  cttctccac  caggaggaa  2280
tacaggcca  gctgtctag  gtaatcgct  accaagacc  tattgctgt  taaaaccta  2340
ataaacaca  agattcacc  gtaaaactt  attttatat  ataaagtat  tcaccttaa  2400
tt  2402



<210> 7948
<211> 662
<212> PRT
<213> Rattus norvegicus
<308> P43322
<400> 7948

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
  1               5                  10                  15
Asp Arg Gly Ser Arg Gly Lys Pro Gly Pro Ala Glu Gly Asp Pro Ser 
             20                  25                  30
Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
         35                  40                  45
Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
     50                  55                  60
Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
 65                  70                  75                  80
Asn Lys Pro Glu Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                 85                  90                  95
Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
             100                105                110
Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
         115                120                125
Ile Val Glu Ser Asn Glu Phe Ile Thr Gly Met Pro Ala Ser Thr Glu 
     130                135                140
Thr Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
 145                150                155                160
Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                 165                170                175
Ser His Leu Ile Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
             180                185                190
Gly Gly Glu Cys Phe Thr Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
         195                200                205
Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
     210                215                220
Val Met Ala Ser Phe Tyr Met Thr Ser Arg Arg Lys Arg Gln Glu Thr 
 225                230                235                240
Glu Lys Pro Leu Glu Arg Lys Leu Asp His Ser Leu Val Lys Glu Ser 
                 245                250                255
Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile 
             260                265                270
Cys Ile Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys 
         275                280                285
Lys Thr Lys Lys Gln Arg Gln Lys Leu His Asp Arg Leu Arg Gln Ser 
     290                295                300
Leu Arg Ser Glu Arg Ser Asn Leu Val Asn Ile Ala Asn Gly Pro His 
 305                310                315                320
His Pro Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val 
                 325                330                335
Ser Lys Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Val Glu 
             340                345                350
Thr Ser Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr 
         355                360                365
Thr Val Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu 
     370                375                380
Ser Val Ile Ser Glu Ser Asn Ser Val Ile Met Met Ser Ser Val Glu 
 385                390                395                400
Asn Ser Arg His Ser Ser Pro Ala Gly Gly Pro Arg Gly Arg Leu His 
                 405                410                415
Gly Leu Gly Gly Pro Arg Asp Asn Ser Phe Leu Arg His Ala Arg Glu 
             420                425                430
Thr Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser 
         435                440                445
Ala Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro 
     450                455                460
Ser Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser 
 465                470                475                480
Met Thr Val Ser Met Pro Ser Val Ala Val Ser Pro Phe Val Glu Glu 
                 485                490                495
Glu Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys 
             500                505                510
Tyr Asp His His Pro Gln Gln Leu Asn Ser Phe His His Asn Pro Ala 
         515                520                525
His Gln Ser Thr Ser Leu Pro Pro Ser Pro Leu Arg Ile Val Glu Asp 
     530                535                540
Glu Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Ser Val Gln Glu Pro Val 
 545                550                555                560
Lys Lys Val Thr Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly 
                 565                570                575
His Ile Ala Asn Arg Leu Glu Met Asp Ser Asn Thr Ser Ser Val Ser 
             580                585                590
Ser Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr 
         595                600                605
Pro Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Val Ala 
     610                615                620
Pro Ala Phe Arg Leu Ala Glu Ser Arg Thr Asn Pro Ala Gly Arg Phe 
 625                630                635                640
Ser Thr Gln Glu Glu Leu Gln Ala Arg Leu Ser Ser Val Ile Ala Asn 
                 645                650                655
Gln Asp Pro Ile Ala Val 
             660



<210> 7949
<211> 886
<212> DNA
<213> Homo sapiens
<308> U02327
<400> 7949

gtgcctctg  caatatcac  atcgtggaa  caaacgaga  catcactgg  atgccagcc  60
caactgaag  agcatatgt  tcttcagag  ctcccatta  aatatcagt  tccacagaa  120
gagcaaata  ttcttcatc  acatctaca  ccaccactg  gacaagcca  cttgtaaaa  180
gtgcggaga  ggagaaaac  ttctgtgtg  atggagggg  gtgcttcat  gtgaaagac  240
tttcaaacc  ctcgagata  ttgtgcaag  gccaacctg  attcactgg  gcaagatgt  300
ctgagaatg  gcccatgaa  gtccaaaac  aagaaagtg  ccaaatgag  ttactggtg  360
tcgctgcca  aactacgta  tggccagct  ctacagtac  tccactccc  ttctgtctc  420
gcctgaata  gagcatgct  agttggtgc  gctttcttg  tgctgcatc  cccctcaga  480
tccacctag  gctagatgt  tcttaccag  tctaatatt  actgcctct  cctgtcgca  540
gagaacatt  acaaaagca  ttgtattac  tcctctgtt  gcgactagt  ggctctgag  600
tactaatag  tgtgtgagg  tccggatgt  tctggaatt  atattgaat  atgtgatac  660
aattgatag  caatatcaa  cagtgaaat  tgataataa  ggcatttca  agtctcact  720
ttattgata  aataaaaat  attctactg  acagtccat  ttctttata  aatgaccac  780
tcctgaaaa  ggtgttgct  agctgtaac  gatatgcac  tgaaatgat  gtaagttaa  840
tttgattca  aatgtgtta  ttgtcacaa  taaacataa  aaaagg  886



<210> 7950
<211> 639
<212> PRT
<213> Homo sapiens
<308> Q12784
<400> 7950

Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys Glu 
  1               5                  10                  15
Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser Pro 
             20                  25                  30
Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala 
         35                  40                  45
Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser 
     50                  55                  60
Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn 
 65                  70                  75                  80
Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu 
                 85                  90                  95
Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys 
             100                105                110
Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile 
         115                120                125
Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly 
     130                135                140
Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu 
 145                150                155                160
Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser 
                 165                170                175
His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly 
             180                185                190
Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu 
         195                200                205
Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn Val 
     210                215                220
Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln Lys 
 225                230                235                240
Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly 
                 245                250                255
Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys 
             260                265                270
Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met 
         275                280                285
Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn 
     290                295                300
Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu 
 305                310                315                320
His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr 
                 325                330                335
Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His 
             340                345                350
Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser 
         355                360                365
Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr 
     370                375                380
Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys 
 385                390                395                400
Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp 
                 405                410                415
Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg 
             420                425                430
Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro 
         435                440                445
Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser 
     450                455                460
Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val 
 465                470                475                480
Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln 
                 485                490                495
Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro 
             500                505                510
Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln 
         515                520                525
Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg 
     530                535                540
Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu 
 545                550                555                560
Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr 
                 565                570                575
Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn 
             580                585                590
Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp 
         595                600                605
Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln 
     610                615                620
Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
 625                630                635



<210> 7951
<211> 648
<212> DNA
<213> Rattus norvegicus
<308> U02506
<400> 7951

aatcccaat  ttaagaggt  aaaaaatag  accagaagt  taaagtaat  cttggctac  60
tagtgagtg  aaggccagc  tggaatcaa  aagagttgg  ttcaaagaa  caggaggag  120
aggaggaac  ggaacagga  gaggagcag  gggaggaga  aaaggagga  gaggaggag  180
aggaagagg  ggaggagga  gaggaggag  aggaggagg  ggaggagga  gaggaggag  240
agaagaaga  gaagaagaa  aagaagaag  agaagaaga  gaagaagaa  aagaagaag  300
agaagaaga  gaagaagaa  aagaagaag  agaagaaga  gaagaagaa  ttagaagaa  360
aaaagaaga  ggacaaatg  ctcttttct  gtctcacct  ttcccttcc  gtcactcat  420
tggacctca  ataagagca  agatactct  gacctctta  atttggaga  ttttgagca  480
acaggaaga  gacggagcc  gggagcagc  gttctccaa  agtcaaatt  agactgttc  540
tctctgagc  ctgtacttc  accagcacc  ttaggcaga  gccatcaaa  cagaaatgt  600
tgttaataa  taaagtcta  gattgccac  aaaaaaaaa  aaaaaaaa  648



<210> 7952
<211> 2741
<212> DNA
<213> Rattus norvegicus
<308> U02522
<400> 7952

ccgccggcg  ccccgcgcc  gcccccgcc  cggcccgcg  ccggcccgc  gcccgcgcc  60
gcgccccgc  cccgcggcc  cgccgccgg  ccggacatg  ccgccaaca  gtacagggt  120
ggagactat  tctactttg  gaactcctc  agcaacccg  acctgatcc  caggattga  180
gagctgaat  agacagcca  cgggaatgt  gaggccaaa  tggtgtgtt  ctacagaag  240
cgggacatt  ccagcagcc  catcgcgct  gctgacaag  atgcaaccc  gtcagtctg  300
tatagagcc  gaccggggg  ggacaccgg  gaggaaggg  aagtggagg  ggaggtaga  360
aacccagag  tggtagacc  gcctgagaa  cttaagcac  agctgcggc  tcgggaact  420
ttcctctct  ggcagttgg  gtctctgcc  gccacccac  tcaggggca  gtgcagtgt  480
accctgctc  atgagaccg  gtcactcaa  tcctacctg  agcgtgagg  tttcttctt  540
tactctcta  tctacgacc  acagcagaa  accctcctg  ctgataaag  cgaaattcg  600
gtagggaac  ggtaccagg  tgacatcac  gatttgctg  aagacggtg  ggaggacgg  660
cgcgatcag  cgaagctgg  gaccaaggt  tgggaagcc  acaatccac  tgtagataa  720
cagattgac  agtttctgg  ggtggcccg  tctgtgggt  cctttgcac  ggccctgga  780
tgcagcagc  ccgtgcggc  gcctagcct  cacatgagt  ccgccgcag  ctcccgaga  840
atcaccctg  ttcatgcca  ggacacgct  cacaagaac  tctacgaca  ctccaaggc  900
atctctgcc  ttgtgcctc  gggtgggcc  gtgctctgc  gggatgaga  ggaggagtg  960
tcagcatca  aagccaacc  ttttgagga  gctctggaa  aatatggga  agatttcac  1020
gacattcag  aagactttc  cccatggaa  tcgctcacc  gcatcattg  gtattacta  1080
atgtggaag  ccaccgaca  atacgtcca  cagaaacgt  tgaaagcag  tgaagcaga  1140
agcaagtta  agcaggttt  tattcccaa  tataacaag  caaacccaa  ccagatcag  1200
gtcaacagt  tcaaggcca  tgtagtgaa  ggcacaggg  caccaggcc  gagccccgg  1260
gccggtcgg  cctgcgaga  ctgttacac  acacagtct  accagtggt  ttcttgggg  1320
ccccctaac  tgcagtgtc  cctctgcgc  tcttgttgg  catattgga  gaaatatgg  1380
ggcttgaaa  tgccaaccc  gttagatgg  gagaggccg  gaccaaacc  caataacat  1440
agtccccat  gcatcccag  tcggagcag  gggagcccc  agtttgcca  gaagacaag  1500
caggccttc  acctgcata  taccaagtt  acacgcatt  cccggcgct  gtgccgtga  1560
atcctacgc  catggcatg  cgcacgcca  ccctacatg  ccatcaaca  tgcagcaat  1620
aaggctgaa  gcacagcac  gctgcccga  gcttcccag  gcccactgg  gctgaagca  1680
gtagtacgg  agcccctgg  ggctgtgct  cggtatctt  agactcatc  ccgcccgcc  1740
aagcccgac  ctgtgaaga  ctcatccag  gtgctcagc  gtctgaccc  tgccaagtc  1800
gcccctgtc  tcaacaatg  ctcccctac  atcttgggc  agaggagct  tgagcagca  1860
aatggggta  atggtctgg  aaaccatgg  cagaccagg  acatgggac  aagtcggaa  1920
ctcctgctc  atgggaagt  ctaccccac  aaagtgcgc  taatccgag  cggctccct  1980
cctccagtc  agcggcggc  gatgaactg  attgacgcc  cagatgatg  attttacat  2040
gccaccgag  agaccagga  aatccgaaa  ctgctctca  cttcagaaa  caagcgtgc  2100
gcccgccgg  cctacaagc  tattgccct  cgccagagc  aggccctgc  gctgcggcc  2160
cccccacct  caccagtca  tgatgagcc  attgttatt  aggactagg  ggtcaccca  2220
agtggcctg  ctgggcccc  ccatcagcc  cagagtatc  agtgaggcc  gcagaggcc  2280
agcggcctc  ctcccccac  agactgctg  ccaccccac  ctctgtttc  gtagtgccc  2340
aactcccgc  ctcacatgc  gagaaactg  tcctctggt  gacatgcgg  ggaagaagt  2400
tggtctaac  tattccaag  caccgagga  tctttttta  ctttgtgtt  actttctgg  2460
tggagcaga  atgaggagt  ccctgggcc  tgggctgca  ggcttctca  ctggggtgg  2520
ctctaaggt  ttgttgtgt  ctgttgaag  tgccatttt  aattttatt  ttattactt  2580
tttgtagat  aacttgagc  ctgtaactt  cacctggaa  gttaggatt  gtgcagcca  2640
cagcggcca  gctgcctgg  agggttggt  ccttgtctt  tcaagtaat  ttcatatta  2700
acaaaaaca  agaaaaaaa  ctcataaaa  ggaaaaccc  a  2741



<210> 7953
<211> 703
<212> PRT
<213> Rattus norvegicus
<308> Q62599
<400> 7953

Met Ala Ala Asn Met Tyr Arg Val Gly Asp Tyr Val Tyr Phe Glu Asn 
  1               5                  10                  15
Ser Ser Ser Asn Pro Tyr Leu Ile Arg Arg Ile Glu Glu Leu Asn Lys 
             20                  25                  30
Thr Ala Asn Gly Asn Val Glu Ala Lys Val Val Cys Phe Tyr Arg Arg 
         35                  40                  45
Arg Asp Ile Ser Ser Ser Leu Ile Ala Leu Ala Asp Lys His Ala Thr 
     50                  55                  60
Leu Ser Val Cys Tyr Arg Ala Gly Pro Gly Ala Asp Thr Gly Glu Glu 
 65                  70                  75                  80
Gly Glu Val Glu Glu Glu Val Glu Asn Pro Glu Met Val Asp Leu Pro 
                 85                  90                  95
Glu Lys Leu Lys His Gln Leu Arg His Arg Glu Leu Phe Leu Ser Arg 
             100                105                110
Gln Leu Glu Ser Leu Pro Ala Thr His Ile Arg Gly Lys Cys Ser Val 
         115                120                125
Thr Leu Leu Asn Glu Thr Glu Ser Leu Lys Ser Tyr Leu Glu Arg Glu 
     130                135                140
Asp Phe Phe Phe Tyr Ser Leu Val Tyr Asp Pro Gln Gln Lys Thr Leu 
 145                150                155                160
Leu Ala Asp Lys Gly Glu Ile Arg Val Gly Asn Arg Tyr Gln Ala Asp 
                 165                170                175
Ile Thr Asp Leu Leu Lys Asp Gly Glu Glu Asp Gly Arg Asp Gln Ser 
             180                185                190
Lys Leu Glu Thr Lys Val Trp Glu Ala His Asn Pro Leu Val Asp Lys 
         195                200                205
Gln Ile Asp Gln Phe Leu Val Val Ala Arg Ser Val Gly Thr Phe Ala 
     210                215                220
Arg Ala Leu Asp Cys Ser Ser Ser Val Arg Gln Pro Ser Leu His Met 
 225                230                235                240
Ser Ala Ala Ala Ala Ser Arg Asp Ile Thr Leu Phe His Ala Met Asp 
                 245                250                255
Thr Leu His Lys Asn Ile Tyr Asp Ile Ser Lys Ala Ile Ser Ala Leu 
             260                265                270
Val Pro Gln Gly Gly Pro Val Leu Cys Arg Asp Glu Met Glu Glu Trp 
         275                280                285
Ser Ala Ser Glu Ala Asn Leu Phe Glu Glu Ala Leu Glu Lys Tyr Gly 
     290                295                300
Lys Asp Phe Thr Asp Ile Gln Gln Asp Phe Leu Pro Trp Lys Ser Leu 
 305                310                315                320
Thr Ser Ile Ile Glu Tyr Tyr Tyr Met Trp Lys Thr Thr Asp Arg Tyr 
                 325                330                335
Val Gln Gln Lys Arg Leu Lys Ala Ala Glu Ala Glu Ser Lys Leu Lys 
             340                345                350
Gln Val Tyr Ile Pro Asn Tyr Asn Lys Pro Asn Pro Asn Gln Ile Ser 
         355                360                365
Val Asn Ser Val Lys Ala Ser Val Val Asn Gly Thr Gly Thr Pro Gly 
     370                375                380
Gln Ser Pro Gly Ala Gly Arg Ala Cys Glu Ser Cys Tyr Thr Thr Gln 
 385                390                395                400
Ser Tyr Gln Trp Tyr Ser Trp Gly Pro Pro Asn Met Gln Cys Arg Leu 
                 405                410                415
Cys Ala Ser Cys Trp Thr Tyr Trp Lys Lys Tyr Gly Gly Leu Lys Met 
             420                425                430
Pro Thr Arg Leu Asp Gly Glu Arg Pro Gly Pro Asn Arg Asn Asn Met 
         435                440                445
Ser Pro His Gly Ile Pro Ala Arg Ser Ser Gly Ser Pro Lys Phe Ala 
     450                455                460
Met Lys Thr Arg Gln Ala Phe Tyr Leu His Thr Thr Lys Leu Thr Arg 
 465                470                475                480
Ile Ala Arg Arg Leu Cys Arg Glu Ile Leu Arg Pro Trp His Ala Ala 
                 485                490                495
Arg His Pro Tyr Met Pro Ile Asn Ser Ala Ala Ile Lys Ala Glu Cys 
             500                505                510
Thr Ala Arg Leu Pro Glu Ala Ser Gln Ser Pro Leu Val Leu Lys Gln 
         515                520                525
Val Val Arg Lys Pro Leu Glu Ala Val Leu Arg Tyr Leu Glu Thr His 
     530                535                540
Pro Arg Pro Pro Lys Pro Asp Pro Val Lys Ser Ser Ser Ser Val Leu 
 545                550                555                560
Ser Ser Leu Thr Pro Ala Lys Ser Ala Pro Val Ile Asn Asn Gly Ser 
                 565                570                575
Pro Thr Ile Leu Gly Lys Arg Ser Tyr Glu Gln His Asn Gly Val Asp 
             580                585                590
Gly Leu Ala Asn His Gly Gln Thr Arg His Met Gly Pro Ser Arg Asn 
         595                600                605
Leu Leu Leu Asn Gly Lys Ser Tyr Pro Thr Lys Val Arg Leu Ile Arg 
     610                615                620
Gly Gly Ser Leu Pro Pro Val Lys Arg Arg Arg Met Asn Trp Ile Asp 
 625                630                635                640
Ala Pro Asp Asp Val Phe Tyr Met Ala Thr Glu Glu Thr Arg Lys Ile 
                 645                650                655
Arg Lys Leu Leu Ser Ser Ser Glu Thr Lys Arg Ala Ala Arg Arg Pro 
             660                665                670
Tyr Lys Pro Ile Ala Leu Arg Gln Ser Gln Ala Leu Pro Leu Arg Pro 
         675                680                685
Pro Pro Pro Ala Pro Val Asn Asp Glu Pro Ile Val Ile Glu Asp 
     690                695                700



<210> 7954
<211> 2662
<212> DNA
<213> Homo sapiens
<308> NM_004689
<400> 7954

cccggacat  gccgccaac  tgtacaggg  cggagacta  gtctacttt  agaactcct  60
cagcaaccc  tacctgatc  ggagaatcg  ggagctcaa  aagacggcc  atgggaacg  120
ggaggccaa  gtggtgtgc  tctaccgga  gcgggacat  tccagcacc  tcatcgccc  180
ggccgacaa  cacgcaacc  tgtcagtct  ctataaggc  ggaccgggg  cggacaacg  240
cgaggaagg  gaaatagaa  aggaaatgg  gaatccgga  atggtggac  tgcccgaga  300
actaaagca  cagctgcgg  atcgggagc  gttcctctc  cggcagctg  agtctctgc  360
cgccacgca  atcaggggc  agtgcagcg  caccctgct  aacgagacc  agtcgctca  420
gtcctacct  gagcgggag  atttcttct  ctattctct  gtctacgac  cacagcaga  480
gaccctgct  gcagataaa  gagagattc  agtaggaaa  cggtaccag  cagacatca  540
cgacttgtt  aaagaaggc  aggaggatg  ccgagacca  tccaggttg  agacccagg  600
gtgggaggc  cacaaccca  tcacagaca  gcagatcga  cagttcctg  tggtggccc  660
ctctgtggg  accttcgca  gggccctgg  ctgcagcag  tccgtccga  agcccagcc  720
gcacatgag  gccgcagct  cctcccgag  catcaccct  ttccacgcc  tggatactc  780
ccacaagaa  atctacgac  tctccaagg  catctcggc  ctggtgccg  agggcgggc  840
cgtgctctg  agggacgag  tggaggagt  gtctgcatc  gaggccaac  ttttcgagg  900
agccctgga  aaatatggg  aggatttca  ggacattca  caagatttt  tcccgtgga  960
gtcgctgac  agcatcatt  agtactact  catgtggaa  accaccgac  gatacgtgc  1020
gcagaaacg  ttgaaagca  ctgaagctg  gagcaagtt  aagcaagtt  atattccca  1080
ctataacaa  ccaaatccg  accaaatca  cgtcaacaa  gtcaaggcc  gtgtggtga  1140
cggcacggg  gcgccgggc  agagccctg  ggctggccg  gcctgcgag  gctgttaca  1200
cacacagtc  taccagtgg  attcttggg  tccccctaa  atgcagtgt  gtctctgcg  1260
atcttgttg  acatattgg  agaaatatg  tggcttgaa  atgccaacc  ggttagatg  1320
agagaggcc  ggaccaaac  gcagtaaca  gagtcccca  ggcctccca  cccggagca  1380
cgggagccc  aagtttgcc  tgaagacca  gcaggcttt  tatctgcac  cgacgaagc  1440
gacgcggat  gcccggcgc  tgtgccgtg  gatcctgcg  ccgtggcac  ctgcgcgga  1500
cccctacct  cccatcaac  gcgcggcca  caaggccga  tgcacggcg  ggctgcccg  1560
agcctccca  agcccgctg  tgctgaagc  ggcggtacg  aagccgctg  aagccgtgc  1620
tcggtatct  gagacccac  cccgccccc  caagcctga  cccgtgaaa  gcgtgtcca  1680
cgtgctcag  agcctgacg  ccgccaagg  ggcccccgt  atcaacaac  gctccccca  1740
catcctggg  aagcgcagc  acgagcagc  caacggggt  gacggcaac  tgaagaagc  1800
cctcttgat  cccagtagg  gtctggcaa  ccacggaca  accaggcac  tgggaccaa  1860
ccggaacct  ctgctcaac  ggaagtcct  ccccaccaa  gtgcgcctg  tccgggggg  1920
ctccctgcc  ccagtcaag  ggcggcgga  gaactggat  gacgccccg  gtgacgtgt  1980
ctacatgcc  aaagaggag  ccaggaaga  ccgcaagct  ctctcatcc  cggaaacca  2040
gcgtgctgc  cgccggccc  acaagccca  cgccctgcg  cagagccag  ccctgccgc  2100
gcggccacc  ccacctgcg  ccgtcaacg  cgagcccat  gtcatcgag  actaggggc  2160
gcccccacc  gcggccgcc  cccgcccct  gcccgccca  acggcccct  cccagccag  2220
ccgccgccc  cccctcagt  tggtagtgc  ccacctccc  ccctcacct  aagagaaac  2280
cgctccttg  cggacactg  gggaggaga  gaagaagcg  ggctaactt  ttccgagaa  2340
gccgaggag  tgtcgtttt  agctttgtg  ttacttttt  gctggagcg  agatgaggg  2400
ccaccccgt  cccctgtgc  gcggggcct  ttgcccgga  gccgggccc  aaggttttg  2460
tgtgttctg  tgaaggtgc  attttaaat  ttattttta  tactttttt  gtagatgaa  2520
ttgagctct  taacttaca  ctggaatgt  aggatcgtg  ggccgcggc  ggccgagct  2580
cctggcggg  ttggccctt  tcttttcaa  taattttca  attaaacaa  aacaaagaa  2640
aaaaatctt  taaaaagga  aa  2662



<210> 7955
<211> 715
<212> PRT
<213> Homo sapiens
<308> Q13330
<400> 7955

Met Ala Ala Asn Met Tyr Arg Val Gly Asp Tyr Val Tyr Phe Glu Asn 
  1               5                  10                  15
Ser Ser Ser Asn Pro Tyr Leu Ile Arg Arg Ile Glu Glu Leu Asn Lys 
             20                  25                  30
Thr Ala Asn Gly Asn Val Glu Ala Lys Val Val Cys Phe Tyr Arg Arg 
         35                  40                  45
Arg Asp Ile Ser Ser Thr Leu Ile Ala Leu Ala Asp Lys His Ala Thr 
     50                  55                  60
Leu Ser Val Cys Tyr Lys Ala Gly Pro Gly Ala Asp Asn Gly Glu Glu 
 65                  70                  75                  80
Gly Glu Ile Glu Glu Glu Met Glu Asn Pro Glu Met Val Asp Leu Pro 
                 85                  90                  95
Glu Lys Leu Lys His Gln Leu Arg His Arg Glu Leu Phe Leu Ser Arg 
             100                105                110
Gln Leu Glu Ser Leu Pro Ala Thr His Ile Arg Gly Lys Cys Ser Val 
         115                120                125
Thr Leu Leu Asn Glu Thr Glu Ser Leu Lys Ser Tyr Leu Glu Arg Glu 
     130                135                140
Asp Phe Phe Phe Tyr Ser Leu Val Tyr Asp Pro Gln Gln Lys Thr Leu 
 145                150                155                160
Leu Ala Asp Lys Gly Glu Ile Arg Val Gly Asn Arg Tyr Gln Ala Asp 
                 165                170                175
Ile Thr Asp Leu Leu Lys Glu Gly Glu Glu Asp Gly Arg Asp Gln Ser 
             180                185                190
Arg Leu Glu Thr Gln Val Trp Glu Ala His Asn Pro Leu Thr Asp Lys 
         195                200                205
Gln Ile Asp Gln Phe Leu Val Val Ala Arg Ser Val Gly Thr Phe Ala 
     210                215                220
Arg Ala Leu Asp Cys Ser Ser Ser Val Arg Gln Pro Ser Leu His Met 
 225                230                235                240
Ser Ala Ala Ala Ala Ser Arg Asp Ile Thr Leu Phe His Ala Met Asp 
                 245                250                255
Thr Leu His Lys Asn Ile Tyr Asp Ile Ser Lys Ala Ile Ser Ala Leu 
             260                265                270
Val Pro Gln Gly Gly Pro Val Leu Cys Arg Asp Glu Met Glu Glu Trp 
         275                280                285
Ser Ala Ser Glu Ala Asn Leu Phe Glu Glu Ala Leu Glu Lys Tyr Gly 
     290                295                300
Lys Asp Phe Thr Asp Ile Gln Gln Asp Phe Leu Pro Trp Lys Ser Leu 
 305                310                315                320
Thr Ser Ile Ile Glu Tyr Tyr Tyr Met Trp Lys Thr Thr Asp Arg Tyr 
                 325                330                335
Val Gln Gln Lys Arg Leu Lys Ala Ala Glu Ala Glu Ser Lys Leu Lys 
             340                345                350
Gln Val Tyr Ile Pro Asn Tyr Asn Lys Pro Asn Pro Asn Gln Ile Ser 
         355                360                365
Val Asn Asn Val Lys Ala Gly Val Val Asn Gly Thr Gly Ala Pro Gly 
     370                375                380
Gln Ser Pro Gly Ala Gly Arg Ala Cys Glu Ser Cys Tyr Thr Thr Gln 
 385                390                395                400
Ser Tyr Gln Trp Tyr Ser Trp Gly Pro Pro Asn Met Gln Cys Arg Leu 
                 405                410                415
Cys Ala Ser Cys Trp Thr Tyr Trp Lys Lys Tyr Gly Gly Leu Lys Met 
             420                425                430
Pro Thr Arg Leu Asp Gly Glu Arg Pro Gly Pro Asn Arg Ser Asn Met 
         435                440                445
Ser Pro His Gly Leu Pro Ala Arg Ser Ser Gly Ser Pro Lys Phe Ala 
     450                455                460
Met Lys Thr Arg Gln Ala Phe Tyr Leu His Thr Thr Lys Leu Thr Arg 
 465                470                475                480
Ile Ala Arg Arg Leu Cys Arg Glu Ile Leu Arg Pro Trp His Ala Ala 
                 485                490                495
Arg Asn Pro Tyr Leu Pro Ile Asn Ser Ala Ala Ile Lys Ala Glu Cys 
             500                505                510
Thr Ala Arg Leu Pro Glu Ala Ser Gln Ser Pro Leu Val Leu Lys Gln 
         515                520                525
Ala Val Arg Lys Pro Leu Glu Ala Val Leu Arg Tyr Leu Glu Thr His 
     530                535                540
Pro Arg Pro Pro Lys Pro Asp Pro Val Lys Ser Val Ser Ser Val Leu 
 545                550                555                560
Ser Ser Leu Thr Pro Ala Lys Val Ala Pro Val Ile Asn Asn Gly Ser 
                 565                570                575
Pro Thr Ile Leu Gly Lys Arg Ser Tyr Glu Gln His Asn Gly Val Asp 
             580                585                590
Gly Asn Met Lys Lys Arg Leu Leu Met Pro Ser Arg Gly Leu Ala Asn 
         595                600                605
His Gly Gln Thr Arg His Met Gly Pro Ser Arg Asn Leu Leu Leu Asn 
     610                615                620
Gly Lys Ser Tyr Pro Thr Lys Val Arg Leu Ile Arg Gly Gly Ser Leu 
 625                630                635                640
Pro Pro Val Lys Arg Arg Arg Met Asn Trp Ile Asp Ala Pro Gly Asp 
                 645                650                655
Val Phe Tyr Met Pro Lys Glu Glu Thr Arg Lys Ile Arg Lys Leu Leu 
             660                665                670
Ser Ser Ser Glu Thr Lys Arg Ala Ala Arg Arg Pro Tyr Lys Pro Ile 
         675                680                685
Ala Leu Arg Gln Ser Gln Ala Leu Pro Pro Arg Pro Pro Pro Pro Ala 
     690                695                700
Pro Val Asn Asp Glu Pro Ile Val Ile Glu Asp 
 705                710                715



<210> 7956
<211> 938
<212> DNA
<213> Rattus norvegicus
<308> U03414
<400> 7956

ccagccctg  ccgagaggc  gtcgcgccg  aaccggtac  ataaatatg  agagcggag  60
ctcagcgca  cagagcccg  gcgccgccc  ccccggctg  taagcaggc  ccgccggag  120
ccgagccgc  gccggagcc  cagccccaa  cacagccgg  agcgcgtcc  cgtccccgc  180
gccgccgac  gccagcacc  aggccctgc  cgctaggac  tcggagtgg  cgcgagaca  240
gcaaccggc  cggaagctc  tcagcctcc  ggtcctcct  gtgatgggc  ccgaactca  300
ccaagtgtt  cccaccaac  ccgaggaga  ctggcaggt  tacagctct  cccaggaca  360
tgagggcag  tgtatctgc  cggtggtcg  cccccagca  accatgtgt  cacgggatg  420
ccgcacaaa  cagctgagg  agctactgg  gaaggtgca  aacatgtct  aatccatag  480
agtcttgga  aggcggact  agagagacc  gcagtacgt  gagaagatg  agaaccaga  540
gaaaggcct  gagtccaag  tcaggcagg  ggaggagag  cataagcag  atctggcca  600
gcagttcaa  ggctaactt  aagagtttt  tcaatgcgc  agtgactga  gaagcagtc  660
ccccatgta  ccatgagag  gccagagag  tttttgcac  atgcatttt  tgattcttt  720
ccaatcctt  gcgccattt  actaaggaa  cttgaatcc  gccaggatc  tccttttgc  780
tgcgactct  gatgcatcc  atgaatagt  tgaaccctt  cttgtcaat  cactttttg  840
aagagaaag  aaaaaaaac  cacaaactt  gtgtatgtg  cctaaagca  gtaacttta  900
gatgctgca  tctcaactg  ctaataaag  cctttccc  938



<210> 7957
<211> 485
<212> PRT
<213> Rattus norvegicus
<308> Q62609
<400> 7957

Met Ser Val Pro Leu Leu Lys Ile Gly Val Val Leu Ser Thr Met Ala 
  1               5                  10                  15
Met Ile Thr Asn Trp Met Ser Gln Thr Leu Pro Ser Leu Val Gly Leu 
             20                  25                  30
Asn Thr Thr Arg Leu Ser Ala Ala Ser Gly Gly Thr Leu Asp Arg Ser 
         35                  40                  45
Thr Gly Val Leu Pro Thr Asn Pro Glu Glu Ser Trp Gln Val Tyr Ser 
     50                  55                  60
Ser Ala Gln Asp Ser Glu Gly Arg Cys Ile Cys Thr Val Val Ala Pro 
 65                  70                  75                  80
Gln Gln Thr Met Cys Ser Arg Asp Ala Arg Thr Lys Gln Leu Arg Gln 
                 85                  90                  95
Leu Leu Glu Lys Val Gln Asn Met Ser Gln Ser Ile Glu Val Leu Asp 
             100                105                110
Arg Arg Thr Gln Arg Asp Leu Gln Tyr Val Glu Lys Met Glu Asn Gln 
         115                120                125
Met Lys Gly Leu Glu Ser Lys Phe Arg Gln Val Glu Glu Ser His Lys 
     130                135                140
Gln His Leu Ala Arg Gln Phe Lys Ala Ile Lys Ala Lys Met Asp Glu 
 145                150                155                160
Leu Arg Pro Leu Ile Pro Val Leu Glu Glu Tyr Lys Ala Asp Ala Lys 
                 165                170                175
Leu Val Leu Gln Phe Lys Glu Glu Val Gln Asn Leu Thr Ser Val Leu 
             180                185                190
Asn Glu Leu Gln Glu Glu Ile Gly Ala Tyr Asp Tyr Asp Glu Leu Gln 
         195                200                205
Ser Arg Val Ser Asn Leu Glu Glu Arg Leu Arg Ala Cys Met Gln Lys 
     210                215                220
Leu Ala Cys Gly Lys Leu Thr Gly Ile Ser Asp Pro Val Thr Val Lys 
 225                230                235                240
Thr Ser Gly Ser Arg Phe Gly Ser Trp Met Thr Asp Pro Leu Ala Pro 
                 245                250                255
Glu Gly Asp Asn Arg Val Trp Tyr Met Asp Gly Tyr His Asn Asn Arg 
             260                265                270
Phe Val Arg Glu Tyr Lys Ser Met Val Asp Phe Met Asn Thr Asp Asn 
         275                280                285
Phe Thr Ser His Arg Leu Pro His Pro Trp Ser Gly Thr Gly Gln Val 
     290                295                300
Val Tyr Asn Gly Ser Ile Tyr Phe Asn Lys Phe Gln Ser His Ile Ile 
 305                310                315                320
Ile Arg Phe Asp Leu Lys Thr Glu Thr Ile Leu Lys Thr Arg Ser Leu 
                 325                330                335
Asp Tyr Ala Gly Tyr Asn Asn Met Tyr His Tyr Ala Trp Gly Gly His 
             340                345                350
Ser Asp Ile Asp Leu Met Val Asp Glu Asn Gly Leu Trp Ala Val Tyr 
         355                360                365
Ala Thr Asn Gln Asn Ala Gly Asn Ile Val Ile Ser Lys Leu Asp Pro 
     370                375                380
Val Ser Leu Gln Ile Leu Gln Thr Trp Asn Thr Ser Tyr Pro Lys Arg 
 385                390                395                400
Ser Ala Gly Glu Ala Phe Ile Ile Cys Gly Thr Leu Tyr Val Thr Asn 
                 405                410                415
Gly Tyr Ser Gly Gly Thr Lys Val His Tyr Ala Tyr Gln Thr Asn Ala 
             420                425                430
Ser Thr Tyr Glu Tyr Ile Asp Ile Pro Phe Gln Asn Lys Tyr Ser His 
         435                440                445
Ile Ser Met Leu Asp Tyr Asn Pro Lys Asp Arg Ala Leu Tyr Ala Trp 
     450                455                460
Asn Asn Gly His Gln Thr Leu Tyr Asn Val Thr Leu Phe His Val Ile 
 465                470                475                480
Arg Ser Asp Glu Leu 
                 485



<210> 7958
<211> 1009
<212> DNA
<213> Homo sapiens
<308> D82343
<400> 7958

gcgcggggg  gccattagg  ggcgaggag  gaggagggc  cagctcccg  ccagcccag  60
cctgcccag  cctgcccgg  ggcagacgc  ccggaaccg  gacgcgata  atatgcaga  120
cggaggctt  gcgcagcag  gcccgcgcg  cgcccgctc  gggtgctga  tccaggcgt  180
gggacacga  ccaggcgcc  ccgccggag  cagcggagc  ggggccaga  ccggagcgc  240
tccgcgtcc  cgcagccgc  ggccggcca  cacccaggg  cctgcatgc  aggtcgttg  300
aggtggcag  gagacatgc  cccggcccg  aagctcctc  gcctcctct  cctcatcct  360
atgggcact  aactcactc  agtgctgcc  accaaccct  aggagagct  gcaggtgta  420
agctctgcc  aggacagcg  gggcaggtg  atctgcaca  tggtcgccc  acagcagac  480
atgtgttca  gggatgccc  cacaaaaca  ctgaggcag  tactggaga  ggtgcagaa  540
atgtctcaa  ccatagagg  cttggacag  cggacccag  gagacttgc  gtacgtgga  600
aagatggag  accaaatga  aggactgga  tccaagttc  aacaggtgg  ggagagtca  660
aagcaacac  tggccaggc  gtttaaggg  taacttaaa  gagtttttt  aatgctgca  720
tgactgaag  agcagtcca  tcccatgta  ccatgaaag  gagccagag  gctttttgc  780
ccatgcatt  ttactatta  tttccaata  ttagcacca  ttcactaag  aaccttgaa  840
acaaccagg  tcctccttt  catgcgact  tagctgcat  tcatgaata  tttgaaccc  900
tgtcaatgc  ttttttgaa  aagaaagaa  aaaaaaact  cgtgtatgt  actcaaagc  960
tgtaacctt  agatgttgc  ttctaaact  acaataaag  cctttcccc  1009



<210> 7959
<211> 485
<212> PRT
<213> Homo sapiens
<308> Q99784
<400> 7959

Met Ser Val Pro Leu Leu Lys Ile Gly Val Val Leu Ser Thr Met Ala 
  1               5                  10                  15
Met Ile Thr Asn Trp Met Ser Gln Thr Leu Pro Ser Leu Val Gly Leu 
             20                  25                  30
Asn Thr Thr Arg Leu Ser Ala Ala Ser Gly Gly Thr Leu Asp Arg Ser 
         35                  40                  45
Thr Gly Val Leu Pro Thr Asn Pro Glu Glu Ser Trp Gln Val Tyr Ser 
     50                  55                  60
Ser Ala Gln Asp Ser Glu Gly Arg Cys Ile Cys Thr Val Val Ala Pro 
 65                  70                  75                  80
Gln Gln Thr Met Cys Ser Arg Asp Ala Arg Thr Lys Gln Leu Arg Gln 
                 85                  90                  95
Leu Leu Glu Lys Val Gln Asn Met Ser Gln Ser Ile Glu Val Leu Asp 
             100                105                110
Arg Arg Thr Gln Arg Asp Leu Gln Tyr Val Glu Lys Met Glu Asn Gln 
         115                120                125
Met Lys Gly Leu Glu Ser Lys Phe Lys Gln Val Glu Glu Ser His Lys 
     130                135                140
Gln His Leu Ala Arg Gln Phe Lys Ala Ile Lys Ala Lys Met Asp Glu 
 145                150                155                160
Leu Arg Pro Leu Ile Pro Val Leu Glu Glu Tyr Lys Ala Asp Ala Lys 
                 165                170                175
Leu Val Leu Gln Phe Lys Glu Glu Val Gln Asn Leu Thr Ser Val Leu 
             180                185                190
Asn Glu Leu Gln Glu Glu Ile Gly Ala Tyr Asp Tyr Asp Glu Leu Gln 
         195                200                205
Ser Arg Val Ser Asn Leu Glu Glu Arg Leu Arg Ala Cys Met Gln Lys 
     210                215                220
Leu Ala Cys Gly Lys Leu Thr Gly Ile Ser Asp Pro Val Thr Val Lys 
 225                230                235                240
Thr Ser Gly Ser Arg Phe Gly Ser Trp Met Thr Asp Pro Leu Ala Pro 
                 245                250                255
Glu Gly Asp Asn Arg Val Trp Tyr Met Asp Gly Tyr His Asn Asn Arg 
             260                265                270
Phe Val Arg Glu Tyr Lys Ser Met Val Asp Phe Met Asn Thr Asp Asn 
         275                280                285
Phe Thr Ser His Arg Leu Pro His Pro Trp Ser Gly Thr Gly Gln Val 
     290                295                300
Val Tyr Asn Gly Ser Ile Tyr Phe Asn Lys Phe Gln Ser His Ile Ile 
 305                310                315                320
Ile Arg Phe Asp Leu Lys Thr Glu Thr Ile Leu Lys Thr Arg Ser Leu 
                 325                330                335
Asp Tyr Ala Gly Tyr Asn Asn Met Tyr His Tyr Ala Trp Gly Gly His 
             340                345                350
Ser Asp Ile Asp Leu Met Val Asp Glu Ser Gly Leu Trp Ala Val Tyr 
         355                360                365
Ala Thr Asn Gln Asn Ala Gly Asn Ile Val Val Ser Arg Leu Asp Pro 
     370                375                380
Val Ser Leu Gln Thr Leu Gln Thr Trp Asn Thr Ser Tyr Pro Lys Arg 
 385                390                395                400
Ser Ala Gly Glu Ala Phe Ile Ile Cys Gly Thr Leu Tyr Val Thr Asn 
                 405                410                415
Gly Tyr Ser Gly Gly Thr Lys Val His Tyr Ala Tyr Gln Thr Asn Ala 
             420                425                430
Ser Thr Tyr Glu Tyr Ile Asp Ile Pro Phe Gln Asn Lys Tyr Ser His 
         435                440                445
Ile Ser Met Leu Asp Tyr Asn Pro Lys Asp Arg Ala Leu Tyr Ala Trp 
     450                455                460
Asn Asn Gly His Gln Ile Leu Tyr Asn Val Thr Leu Phe His Val Ile 
 465                470                475                480
Arg Ser Asp Glu Leu 
                 485



<210> 7960
<211> 2065
<212> DNA
<213> Rattus norvegicus
<308> U04317
<400> 7960

aggagaaaa  actgggata  gctagcttg  tagctccag  aagcggcgg  atgcgcggt  60
tttaaaata  acagacata  aggctttgg  ggagaggaa  aagtgcctg  gatgaagaa  120
agatgcacc  acccggcag  ggtgaaatc  caagctaca  tgatttctc  tttggaccc  180
acatcagac  gcacacatc  accgcctag  ggactcacc  ttaccttcc  gtgccattg  240
catcggaga  atctcggcc  tcaatcact  gcacatgat  ggcaaatgg  gaatggggc  300
ttgggcttt  gcaattctg  cagttccca  gtatttcat  gtgacagag  gcagaaaaa  360
atcctgggg  ctagaaaac  aggctttaa  tgtcagatg  ccccaaaga  gaggtgcga  420
taaccctgt  gaatggtat  attcaaata  aaatgaaag  attcctact  aaaagagaa  480
tcggatctt  gtctcaaga  atcgtctga  gtttctacc  gccaaagtg  aagactctg  540
gatttatac  tgtgttatc  gaagccctg  atcgattaa  accggatct  tgaatgtca  600
catatataa  agaccacca  actgcaaaa  ccctgatta  atgatgtac  cgacagtag  660
tggatcaga  aaaaattcc  agataacat  tccaacaat  gccttgtat  attggacag  720
gcctgttca  tggtttaag  actgcaaag  tctccaagg  ccaaggttc  gggcacaca  780
gtcctattt  ttcattgac  aagtgagtc  tgttgatga  ggtgactac  catgtcgat  840
cactcacac  gagaacgga  ccaattaca  tgtgactgc  accagatca  tcacagttg  900
agaaaaagg  ttctctaca  ttccagtaa  tacaaaccc  ccacacaac  acacagtgg  960
agtggaaat  ggaaaaaca  caaacattg  ctgctcagc  tgctttggc  cagcctctc  1020
gttcgttgc  gtcctgtgg  agattaaca  aacgagaat  ggatctttt  gcaaagcaa  1080
aattcaaga  gagaaaggc  caaataaaa  ttccagcaa  ggcatgatt  gcttaacct  1140
actgttaag  ataactggt  tgaccgaca  ggacttctc  ctgaaatat  actgtgtgg  1200
catgaacca  cacggagtg  taaggcacc  cgtaagact  agaaggaaa  aaccaattg  1260
ccaccaaag  acctactac  tagttgccg  atgtagttt  ttgctaatg  ttatcaatg  1320
cttggtgat  gtcttaaaa  tgttctgga  tgaggttgc  ctgttctgg  gagatataa  1380
ggcacctta  aaaacccag  atgatggaa  gctctatga  gcttacatc  tttaccctc  1440
ggtcttccg  ggcagcgca  cagggaccg  ctctgtgga  tactttgtt  actacactc  1500
gcccgacgt  ctcgaaaat  aatgtggct  caagttgtg  atttacggg  gagacctgc  1560
gcctgggca  gatgcggcc  ctgtggtgg  aagcagtat  cagaatagt  gacggcaag  1620
gtttgtcct  gcccctcac  tgatgcaca  caaagagtt  gcctatgag  aggagatcg  1680
cctgcacag  gccctcatc  agaacaact  caaggtgat  ctgattgaa  tggagccta  1740
gggtgaggc  agccgactg  agcttgggg  tctgcaaga  tctctccag  atcttgtga  1800
aatgcaggg  accatcaag  ggagggaag  ccacgtggc  gacaaacag  ctctaagct  1860
caaattctg  aagcatgtg  gataccaaa  gccagtccc  aaaagaccc  ccaagatgg  1920
atctgttgc  gctccgttg  gtggcaagg  gtgcttgga  ctgaaacac  tttgagtcg  1980
ggacttgcc  actcagagc  ggggaatcc  agcagtagg  cccagaagt  aaggtgtga  2040
gacttgaaa  gccaagggt  gggcc  2065



<210> 7961
<211> 566
<212> PRT
<213> Rattus norvegicus
<308> AAA18480
<400> 7961

Met Ile Gly Lys Trp Arg Met Gly Leu Trp Ala Leu Ala Ile Leu Thr 
  1               5                  10                  15
Val Pro Met Tyr Phe Ile Val Thr Glu Gly Arg Lys Thr Ser Trp Gly 
             20                  25                  30
Leu Glu Asn Glu Ala Leu Ile Val Arg Cys Pro Gln Arg Gly Gly Ala 
         35                  40                  45
Ile Asn Pro Val Glu Trp Tyr Tyr Ser Asn Thr Asn Glu Arg Ile Pro 
     50                  55                  60
Thr Gln Lys Arg Asn Arg Ile Phe Val Ser Arg Asp Arg Leu Lys Phe 
 65                  70                  75                  80
Leu Pro Ala Lys Val Glu Asp Ser Gly Ile Tyr Thr Cys Val Ile Arg 
                 85                  90                  95
Ser Pro Glu Ser Ile Lys Thr Gly Ser Leu Asn Val Thr Ile Tyr Lys 
             100                105                110
Arg Pro Pro Asn Cys Lys Ile Pro Asp Tyr Met Met Tyr Ser Thr Val 
         115                120                125
Asp Gly Ser Asp Lys Asn Ser Lys Ile Thr Cys Pro Thr Ile Ala Leu 
     130                135                140
Tyr Asn Trp Thr Ala Pro Val Gln Trp Phe Lys Asn Cys Lys Ala Leu 
 145                150                155                160
Gln Gly Pro Arg Phe Arg Ala His Met Ser Tyr Leu Phe Ile Asp Lys 
                 165                170                175
Val Ser His Val Asp Glu Gly Asp Tyr Thr Cys Arg Phe Thr His Thr 
             180                185                190
Glu Asn Gly Thr Asn Tyr Ile Val Thr Ala Thr Arg Ser Phe Thr Val 
         195                200                205
Glu Glu Lys Gly Phe Ser Thr Phe Pro Val Ile Thr Asn Pro Pro His 
     210                215                220
Asn Tyr Thr Val Glu Val Glu Ile Gly Lys Thr Ala Asn Ile Ala Cys 
 225                230                235                240
Ser Ala Cys Phe Gly Thr Ala Ser Gln Phe Val Ala Val Leu Trp Gln 
                 245                250                255
Ile Asn Lys Thr Arg Ile Gly Ser Phe Gly Lys Ala Arg Ile Gln Glu 
             260                265                270
Glu Lys Gly Pro Asn Lys Ser Ser Ser Asn Gly Met Ile Cys Leu Thr 
         275                280                285
Ser Leu Leu Arg Ile Thr Gly Val Thr Asp Lys Asp Phe Ser Leu Lys 
     290                295                300
Tyr Asp Cys Val Ala Met Asn His His Gly Val Ile Arg His Pro Val 
 305                310                315                320
Arg Leu Arg Arg Lys Gln Pro Ile Asp His Gln Ser Thr Tyr Tyr Ile 
                 325                330                335
Val Ala Gly Cys Ser Leu Leu Leu Met Phe Ile Asn Val Leu Val Ile 
             340                345                350
Val Leu Lys Val Phe Trp Ile Glu Val Ala Leu Phe Trp Arg Asp Ile 
         355                360                365
Met Ala Pro Tyr Lys Thr Gln Asn Asp Gly Lys Leu Tyr Asp Ala Tyr 
     370                375                380
Ile Ile Tyr Pro Arg Val Phe Arg Gly Ser Ala Ala Gly Thr Gly Ser 
 385                390                395                400
Val Glu Tyr Phe Val His Tyr Thr Leu Pro Asp Val Leu Glu Asn Lys 
                 405                410                415
Cys Gly Tyr Lys Leu Cys Ile Tyr Gly Arg Asp Leu Leu Pro Gly Gln 
             420                425                430
Asp Ala Ala Thr Val Val Glu Ser Ser Ile Gln Asn Ser Arg Arg Gln 
         435                440                445
Val Phe Val Leu Ala Pro His Met Met His Ser Lys Glu Phe Ala Tyr 
     450                455                460
Glu Gln Glu Ile Ala Leu His Ser Ala Leu Ile Gln Asn Asn Ser Lys 
 465                470                475                480
Val Ile Leu Ile Glu Met Glu Pro Met Gly Glu Ala Ser Arg Leu Gln 
                 485                490                495
Leu Gly Asp Leu Gln Asp Ser Leu Gln His Leu Val Lys Met Gln Gly 
             500                505                510
Thr Ile Lys Trp Arg Glu Asp His Val Ala Asp Lys Gln Ser Leu Ser 
         515                520                525
Ser Lys Phe Trp Lys His Val Arg Tyr Gln Met Pro Val Pro Lys Arg 
     530                535                540
Pro Pro Lys Met Ala Ser Val Ala Ala Pro Leu Ser Gly Lys Val Cys 
 545                550                555                560
Leu Asp Leu Lys His Phe 
                 565



<210> 7962
<211> 2058
<212> DNA
<213> Homo sapiens
<308> AB012701
<400> 7962

aaagagagg  tggctgttg  atttagtaa  gctataaag  tgtaagaga  attggcttt  60
tgagttgtg  aactgtggg  agaaagttg  ggaagaaag  actcaagta  aacccaatg  120
ggttgagat  taggctact  ttcccaact  agtcttgaa  agtatcacc  actgcctca  180
gtgtggtga  cttcactgt  gtatgccag  gactcatct  gagtaatct  aacaacgag  240
taccaatac  tgctcttga  tgataaaca  aatggggtt  tggatctta  caattctca  300
aattctcat  tattccaca  cagcaaagt  tagtaaaca  tcatggggc  tggaaaatg  360
ggctttaat  gtaagatgt  ctagacaag  aaaacctag  tacaccgtg  attggtatt  420
ctcacaaac  aacaaaagt  ttcccactc  ggaaagaaa  cgtgtgttt  cctcaggcc  480
acttctgaa  tttctacca  ctgaagttg  tgattctgg  atttatacc  gtattgtca  540
aagtcccac  ttcaatagg  ctggatatg  gaatgtcac  atatataaa  aacaatcag  600
ttgcaatgt  ccagattat  tgatgtatt  aacagtatc  ggatcagaa  aaaattcca  660
aatttattg  cctaccatt  acctctaca  ctggacagc  cctcttgag  ggtttaaga  720
ttgtcaggc  cttcaagga  caaggtaca  ggcgcacaa  tcatttttg  tcattgata  780
tgtgatgac  gaggacgca  gtgattaca  ctgtaaatt  atacacaat  aaaatggag  840
caattatag  gtgacggcg  ccaggtcct  cacggtcaa  gatgagcaa  gcttttctc  900
gtttccagt  atcggagcc  ctgcacaaa  tgaaataaa  gaagtggaa  ttggaaaaa  960
cgcaaacct  acttgctct  cttgttttg  aaaaggcac  cagttcttg  ctgccgtcc  1020
gtggcagct  aatggaaca  aaattacag  ctttggtga  ccaagaatt  aacaagagg  1080
agggcaaaa  caaagtttc  gcaatgggc  ggcttgtct  gacatggtt  taagaatag  1140
tgacgtgaa  gaagaggat  tattgctgc  gtacgactg  ctggccctg  atttgcatg  1200
cttgagaag  cacaccgta  gactaagta  gaaaaatcc  attgatcat  atagcatct  1260
ctgcataat  gcagtatgt  gtgtatttt  aatgctaat  aatgtcctg  ttatcatcc  1320
aaaaatgtt  tggattgag  ccactctgc  ctggagaga  atagctaaa  cttacaaga  1380
taggaatga  ggaaagctc  atgatgctt  tgttgtcta  ccacggaac  acaaatcca  1440
tacagatgg  gccagtcgt  tagagcact  tgttcacca  attctgcct  atgttcttg  1500
aaataaatg  ggctatacc  tatgcattt  tgggagaga  atgctacct  gagaagatg  1560
agtcactgc  gtggaaacc  acatacgaa  gagcaggcg  cacattttc  tcctgaccc  1620
tcagatcac  cacaataag  agtttgcct  cgagcagga  gttgccctg  actgtgccc  1680
catccagaa  gacgccaag  tgatactta  tgagatgga  gctctgagc  agctggaca  1740
gctgcaggc  gaggcgctt  aggactccc  ccagcatct  atgaaagta  aggggacca  1800
caagtggag  gaggaccac  ttgccaata  aaggtccct  aattccaaa  tctggaagc  1860
cgtgaggta  caaatgcct  tgccaagca  aattcccag  aaggcctct  gtttgactc  1920
cttggctgc  cagaagcaa  agtgcctgc  gtgatgtgc  aagggatct  ggtttgaag  1980
tttcctgac  tctcctagc  ggcttatgc  cctgcactg  agtgtgagg  gcgggaata  2040
taaagggat  caggccac  2058



<210> 7963
<211> 328
<212> PRT
<213> Homo sapiens
<308> Q01638
<400> 7963

Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
  1               5                  10                  15
Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
             20                  25                  30
Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp 
         35                  40                  45
Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg 
     50                  55                  60
Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Glu Val Ala 
 65                  70                  75                  80
Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg 
                 85                  90                  95
Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn 
             100                105                110
Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn 
         115                120                125
Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro 
     130                135                140
Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg 
 145                150                155                160
Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala 
                 165                170                175
Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr 
             180                185                190
Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe 
         195                200                205
Ser Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu 
     210                215                220
Val Glu Ile Gly Lys Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly 
 225                230                235                240
Lys Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr 
                 245                250                255
Lys Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln 
             260                265                270
Asn Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg 
         275                280                285
Ile Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu 
     290                295                300
Ala Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg 
 305                310                315                320
Lys Asn Pro Ser Lys Glu Cys Phe 
                 325



<210> 7964
<211> 6801
<212> DNA
<213> Rattus norvegicus
<308> U04998
<400> 7964

cctagaccc  ggccagtca  cggcgtccc  tgtctcggt  ttcccactc  ctgcaccct  60
agctgtacc  ctgcggctg  cgaggggcc  cggacccgg  tggagatgc  aatcctgca  120
agcttcctc  cgtgcgttc  gctactgtg  gtgtgtcgc  tggactggg  ttatggata  180
tacagacaa  agagaaaac  tgttgaaga  attggctgg  cctatacag  agcactaaa  240
caaaaaaat  ggggaaaga  atatccaat  tgtaatagc  caaagcagt  tcctattaa  300
attgatgaa  atcttacac  agtaaatgt  aatcttaag  aactgaaat  tcagggttg  360
gaaaaacca  ccttggaaa  cacgtttat  cacaacact  ggaaaacag  ggaaataaa  420
ctcaccaat  actactatc  cagtggagg  ctttcagaa  aggtcttca  ggcaagcaa  480
atgactttt  actggggga  atgcaatgt  tcatcggaa  gatcggaac  cagcttaga  540
gggcagaag  ttccactcg  gatgcaaat  tactgcttc  atgcggacc  attttcaag  600
tttgaggaa  cagttaaag  aaaaggaag  ttaagggct  tatccattt  atttgagat  660
ggagttgaa  aaaatttgg  ttacaaagc  attattgat  ggactgaaa  tgttagtcg  720
tttggaaag  aggctgcct  agatccgtt  atcttgcag  acctcctgc  aaactccac  780
gacaagtac  acatttaca  cggatcact  acatcccct  cctgcacag  caccgtcga  840
tggattgtt  ttaaggata  agttagcat  tctgaaagc  agctggctg  attttgtga  900
gttctcaca  tgcaacagt  cgggtatgt  atgttgatg  attacttac  aaacaattt  960
cgagaacaa  agtacaagt  ttccaggca  gtgttttct  cgtacactg  gaaggaaga  1020
attcatgaa  cagtgtgca  ttcagaacc  gaaaatgtg  aagctgacc  tgagaatta  1080
accagcctt  tgatcacat  ggaaaggcc  cgggttgtt  atgacacaa  gattgagaa  1140
tttgcggtt  tgtaccagc  actggaggg  aacgaccaa  ccaagcatg  gtttttaac  1200
gatggctat  aggacttgg  tgccattct  aataactta  tacctaaca  gagttatgt  1260
ctccaaata  tggccatat  ctctaatgg  ctttatgga  agtacagtg  ccaattgat  1320
gtcgacatg  ctactgagg  tgctgaact  gacctcttt  ctgaattaa  tggaactga  1380
gaaataatc  aggaggaaa  ctatggaaa  ggcaatgaa  aagacactg  cttgaatcc  1440
ggtagagac  gtgccacaa  ccaaataag  aaaaaggaa  cccaggttt  taccacaac  1500
cactataat  acatgggga  taaatataa  gaagccaag  ctaaccgat  tccaacgag  1560
ggatctgaa  tctctggaa  gagtgatgt  ctcaacaca  ccctgaatc  tacttccca  1620
caggttgct  aattcaatc  agaaagaga  atgtccttg  cttctcaga  tggaactaa  1680
ctgccacca  acagtgtgg  aggcacctc  gcctcctta  acagtggct  taaaactct  1740
cttgtcttc  cacagatga  cttgtctgg  actgcagaa  ccttaaata  ggtttccat  1800
acagagtac  aagaggtgt  tgctgacct  agtgaggaa  aaaacttac  gactgattt  1860
aagctcgat  gtggagcag  tgattcgtc  ggctctagc  ctgcatcct  cactgtccc  1920
ttttccaca  ataatctat  ccatggata  acgtcttct  cagacacgc  cgaggcggt  1980
acgtatgat  tccttaggc  agaatctac  agaaatgct  tagaggatt  ggctccatc  2040
ggttcagaa  aatcactaa  ggatccctc  cttgaaggg  gtgtgtggt  ccctggatc  2100
acagaccta  caacacagt  tgagactgg  tctgggaga  agggctttc  ccaagttaa  2160
tccacggac  tccaagttg  tgaatcgag  gagacaact  agacatttt  tccagatgc  2220
accgcgtcc  ggggtcctt  ggtcacaga  atggaaatg  cacattatt  tacctttgc  2280
taccccccg  ctgaagtaa  atcacatgc  ttcactccg  cctccagac  acttgattt  2340
gctcccact  gcaacatcc  ccattcgca  acaactcaa  cagtataca  tggtgagac  2400
cctcttcaa  cttcctaca  tagtgaagt  tttcctcta  tcacccctt  gttgcttga  2460
aatcagacc  tcaacacta  ccctgctgc  tcaagtagt  attcggcct  gcatgctac  2520
cctgtattc  ccagtgttg  tgtgtcatt  gactccatc  tgtcttcct  tgatgatgc  2580
cctctgctc  cattttcct  tgcttcctt  agtagtgac  tgtttcacc  tctgcatac  2640
gtttctcaa  cccttccgc  agttacttc  gctgctgag  gggatgagc  gtctttgca  2700
gcttctctg  tggtggctg  gggtgattt  ctgttagag  ccagccttg  tcagtattc  2760
gatgtgatg  cacatcagg  cactattca  gctgcttcg  acacattgg  atttggtag  2820
gagtctgct  tcctttata  aacgtctat  gtttctcaa  tcgaatcac  cagcagtga  2880
gtcgttatg  atgcatatt  gtcagggcc  gaaacttct  atgccattg  gggctccca  2940
cacgtgctc  ctgtttctt  cagttctgc  atacctgtg  atgattctg  cggtgtagc  3000
gatcagggg  ccttactta  caatcctag  catatatca  tgcctgagt  ctcatttat  3060
actccaact  catcattac  gcagcttcc  cctgccctc  ctggtgatg  ggagtggtc  3120
ggagcctcc  ctgatagtg  attgctttt  cctgacaca  atgggctga  aactcttaa  3180
atgtcttca  ctgtttctg  agctgattt  acatacacg  catctgtgt  tggcgatga  3240
attaagccg  tttctaaag  tgaaatgat  tatggaaat  agaccgaac  gaaaatgtc  3300
tctttcagt  acatggcat  cccttctaa  agcacagtc  tgccaaaga  gtctgatat  3360
gtaaataag  ggagtgaat  tttaaaaga  acctctgtt  ccgtatcta  cataaacag  3420
gtgtttaca  agtctcttg  ttatcccat  actaaggtt  ttgatcagg  gattagtcg  3480
gttccagag  ttatcttcc  agttaaacc  acacacaca  catctcaag  atctggtga  3540
acttggctt  aacccgggc  tagcacaaa  tcagagcct  cgctctctg  cactgcttc  3600
agtgaagta  cacaccctt  aacacagcc  ttgctctat  aggccgcat  tccttttaa  3660
acggaagca  tgctgcaac  ttcctttcc  gcttctgat  ttgacacct  gcttaaaac  3720
gcccttccc  ctgggcctc  tgatccagt  ctgactgaa  cccccatgg  tgagcaaag  3780
agctcttcc  tatctcttc  cctggcatc  gagtctgct  caagcaaaa  cacgctgca  3840
tttacatct  taccagttc  caatatgtc  ccttctgat  tgcacccca  ttcacttca  3900
cgcttaaca  ttcctcact  gagggagga  tattttgaa  aaggtttgc  taagagcaa  3960
agtccccag  aagtcctgc  gtccttgca  agccatgac  agtttttcc  aactgcaca  4020
ctggacatt  gccaggcct  ccctccaaa  ggaaggcat  catttgcta  tcctatttt  4080
tcaatcaat  aaccacaaa  tacacttat  aacaggctt  tgtattctg  ggacatttt  4140
atgcaccct  aaatttcta  tactgataa  gcacttact  gtctaccaa  gaccgtttc  4200
gatgtactt  tagctactg  ccattctgt  ccattagga  gtgggccca  ttccatgac  4260
actgtttct  ccaacagag  tgattctgt  accacaacc  agttgcttc  tccttctaa  4320
gctacttct  agccgactc  tagtgccag  tctgatgcc  atttagtag  aggtggtga  4380
gatggtgat  actatgatg  tgatgatta  gatgacata  atagtgatc  ctttcccgt  4440
aataagtgt  tgtcatgtt  accctatag  gaatcacag  aaaaggtaa  gaatgactc  4500
gacacccaa  aaagcagtc  tgtggatca  agtgaccca  tttcacatt  gctctctga  4560
aataccgaa  aagaaaatg  aggcacggg  gtaactagg  tggataaaa  tcctgataa  4620
tcaccacca  caagtatgc  accccagaa  cacaatgat  gaagagagg  ccgtgacat  4680
cagatgggt  gtgctgtcc  tcctcacac  ccaggatct  aagcatggg  agttttgac  4740
agtgatgaa  agagtgggt  agggcaagg  acctcagat  gccttaatg  taatgagac  4800
tccacagat  tcagtttcc  agatgttaa  gaaaaggat  ctgatggtg  cctggaagc  4860
gatgacaca  gcatagctc  gggatctcc  cggtcctcc  caccatctg  tactagtgg  4920
cattcagga  tatccaaca  ttcagaggc  ggttagtta  gagcaaagg  atagaacga  4980
atgtgctga  tttcttgct  tgaaagtaa  aatagaaga  tcacggaag  aaagaattc  5040
ggtccacca  cagatcttc  ctttctaat  agaacgttc  atacattta  agctcttat  5100
aatatggtt  tactcatga  ttcgaatga  tatccaaca  attttggtt  ttgattttt  5160
ttatcttca  aatgcattg  gtgctgtta  taatcccta  tcctattgt  tgtagtatc  5220
actatgtat  cataatacg  cattagaat  ttacaacgc  gtgtgctgt  ttaagacag  5280
ttaaatgtt  atacttgta  tctgaaaca  gttgtacac  aactctatt  gatttaaaa  5340
ctcagtaat  tgctataag  acccatcca  caatggtgg  cacttcaca  gtgcacaac  5400
gcttggaga  cttctcaaa  gaactacag  gctaagatt  gatagctaa  gaaggtttt  5460
ataaacatc  tactgcttt  aaactatcc  tgagcttct  ttttgttgc  taaagaggg  5520
agtataaac  accaaaata  attctactt  gtgtttgtt  cagtattcc  acttactaa  5580
cgacatgaa  atgcagaag  tgcataggt  ttgtatgac  agatgtaaa  gaaaaagcc  5640
acagccttt  ctgtagaga  gcatttcat  gttaatata  tttatgcaa  tgggtttat  5700
agccagatg  ttcttggag  agactgcaa  ctagaatac  gatgtgtgc  ttaaatgtc  5760
atggtaaca  aattcgaaa  tccattaag  gtttaaaaa  aaaactagg  gattccatt  5820
aattcacgg  aagaatttt  taatttgct  tgattaagt  atgaggttt  tttttaatg  5880
acaaggaaa  tatttaaat  ttagcaagt  aaaagataa  ataatgtat  atgtgacat  5940
gggtaataa  tgcacagag  ttaatatta  aaatccaca  tatagagcc  atctcatta  6000
aatatatat  ctctttgtt  ttttcatca  tcacattag  tgtaaactc  ttagtatgg  6060
agcaattaa  agattatat  tttagataa  acagtttct  tcttttctg  attctgacg  6120
gatctccac  taacgttga  tttcagctt  aatatatga  ctgatgtgt  agaaggagt  6180
atgagtcca  gggtcactg  agtcaggaa  gttgttaca  atgtgaatt  ttatctgtc  6240
tcaattata  cacttgttt  tctttctat  tttttagat  tatctgaaa  ggaaagatc  6300
tgaacatac  ctaatggac  gaccatgca  atacatata  cccaaagca  tatatctag  6360
attatcgaa  aaagttatt  ctcttagat  tactaatta  atttattta  ctgttaaga  6420
taagttccc  cactaatga  aacacagca  tatggataa  acatccatc  tcaggaaat  6480
atacagtta  tgaagggag  aggatcaaa  agaattagg  aaaacaatt  ttacctgtt  6540
ttaaagctg  atctgtaaa  ctaattcaa  gtcagtctt  tccaattat  gaatattcc  6600
tagtctgaa  ctcatcatt  atggtactt  taaattgta  aaaaactga  atgatgttt  6660
ctaaactaa  ataaatagg  caaatatag  tgagagtga  caaagactg  aagatactt  6720
ctctggttc  cataaagag  ccatccaaa  ctaaccctg  gaatgtatt  ttagtgtct  6780
tctcttaga  catgcttac  t  6801



<210> 7965
<211> 2316
<212> PRT
<213> Rattus norvegicus
<308> Q62656
<400> 7965

Met Arg Ile Leu Gln Ser Phe Leu Ala Cys Val Gln Leu Leu Cys Val 
  1               5                  10                  15
Cys Arg Leu Asp Trp Ala Tyr Gly Tyr Tyr Arg Gln Gln Arg Lys Leu 
             20                  25                  30
Val Glu Glu Ile Gly Trp Ser Tyr Thr Gly Ala Leu Asn Gln Lys Asn 
         35                  40                  45
Trp Gly Lys Lys Tyr Pro Ile Cys Asn Ser Pro Lys Gln Ser Pro Ile 
     50                  55                  60
Asn Ile Asp Glu Asp Leu Thr Gln Val Asn Val Asn Leu Lys Lys Leu 
 65                  70                  75                  80
Lys Phe Gln Gly Trp Glu Lys Pro Ser Leu Glu Asn Thr Phe Ile His 
                 85                  90                  95
Asn Thr Gly Lys Thr Val Glu Ile Asn Leu Thr Asn Asp Tyr Tyr Leu 
             100                105                110
Ser Gly Gly Leu Ser Glu Lys Val Phe Lys Ala Ser Lys Met Thr Phe 
         115                120                125
His Trp Gly Lys Cys Asn Val Ser Ser Glu Gly Ser Glu His Ser Leu 
     130                135                140
Glu Gly Gln Lys Phe Pro Leu Glu Met Gln Ile Tyr Cys Phe Asp Ala 
 145                150                155                160
Asp Arg Phe Ser Ser Phe Glu Glu Thr Val Lys Gly Lys Gly Arg Leu 
                 165                170                175
Arg Ala Leu Ser Ile Leu Phe Glu Ile Gly Val Glu Glu Asn Leu Asp 
             180                185                190
Tyr Lys Ala Ile Ile Asp Gly Thr Glu Ser Val Ser Arg Phe Gly Lys 
         195                200                205
Gln Ala Ala Leu Asp Pro Phe Ile Leu Gln Asn Leu Leu Pro Asn Ser 
     210                215                220
Thr Asp Lys Tyr Tyr Ile Tyr Asn Gly Ser Leu Thr Ser Pro Pro Cys 
 225                230                235                240
Thr Asp Thr Val Glu Trp Ile Val Phe Lys Asp Thr Val Ser Ile Ser 
                 245                250                255
Glu Ser Gln Leu Ala Val Phe Cys Glu Val Leu Thr Met Gln Gln Ser 
             260                265                270
Gly Tyr Val Met Leu Met Asp Tyr Leu Gln Asn Asn Phe Arg Glu Gln 
         275                280                285
Gln Tyr Lys Phe Ser Arg Gln Val Phe Ser Ser Tyr Thr Gly Lys Glu 
     290                295                300
Glu Ile His Glu Ala Val Cys Ser Ser Glu Pro Glu Asn Val Gln Ala 
 305                310                315                320
Asp Pro Glu Asn Tyr Thr Ser Leu Leu Ile Thr Trp Glu Arg Pro Arg 
                 325                330                335
Val Val Tyr Asp Thr Met Ile Glu Lys Phe Ala Val Leu Tyr Gln Pro 
             340                345                350
Leu Glu Gly Asn Asp Gln Thr Lys His Glu Phe Leu Thr Asp Gly Tyr 
         355                360                365
Gln Asp Leu Gly Ala Ile Leu Asn Asn Leu Ile Pro Asn Met Ser Tyr 
     370                375                380
Val Leu Gln Ile Val Ala Ile Cys Ser Asn Gly Leu Tyr Gly Lys Tyr 
 385                390                395                400
Ser Asp Gln Leu Ile Val Asp Met Pro Thr Glu Asp Ala Glu Leu Asp 
                 405                410                415
Leu Phe Pro Glu Leu Ile Gly Thr Glu Glu Ile Ile Lys Glu Glu Asn 
             420                425                430
Tyr Gly Lys Gly Asn Glu Glu Asp Thr Gly Leu Asn Pro Gly Arg Asp 
         435                440                445
Ser Ala Thr Asn Gln Ile Arg Lys Lys Glu Pro Gln Val Ser Thr Thr 
     450                455                460
Thr His Tyr Asn His Met Gly Thr Lys Tyr Asn Glu Ala Lys Thr Asn 
 465                470                475                480
Arg Ser Pro Thr Arg Gly Ser Glu Phe Ser Gly Lys Ser Asp Val Leu 
                 485                490                495
Asn Thr Ser Leu Asn Pro Thr Ser Gln Gln Val Ala Glu Phe Asn Pro 
             500                505                510
Glu Arg Glu Met Ser Leu Pro Ser Gln Ile Gly Thr Asn Leu Pro Pro 
         515                520                525
His Ser Val Glu Gly Thr Ser Ala Ser Leu Asn Ser Gly Ser Lys Thr 
     530                535                540
Leu Leu Val Phe Pro Gln Met Asn Leu Ser Gly Thr Ala Glu Ser Leu 
 545                550                555                560
Asn Met Val Ser Ile Thr Glu Tyr Lys Glu Val Ser Ala Asp Leu Ser 
                 565                570                575
Glu Glu Glu Asn Leu Leu Thr Asp Phe Lys Leu Asp Ser Gly Ala Asp 
             580                585                590
Asp Ser Ser Gly Ser Ser Pro Ala Ser Ser Thr Val Pro Phe Ser Thr 
         595                600                605
Asp Asn Leu Ser His Gly Tyr Thr Ser Ser Ser Asp Thr Pro Glu Ala 
     610                615                620
Val Thr Tyr Asp Val Leu Arg Pro Glu Ser Thr Arg Asn Ala Leu Glu 
 625                630                635                640
Asp Ser Ala Pro Ser Gly Ser Glu Glu Ser Leu Lys Asp Pro Ser Leu 
                 645                650                655
Glu Gly Ser Val Trp Phe Pro Gly Ser Thr Asp Leu Thr Thr Gln Ser 
             660                665                670
Glu Thr Gly Ser Gly Arg Glu Gly Phe Leu Gln Val Asn Ser Thr Asp 
         675                680                685
Phe Gln Val Asp Glu Ser Arg Glu Thr Thr Glu Thr Phe Ser Pro Asp 
     690                695                700
Ala Thr Ala Ser Arg Gly Pro Ser Val Thr Asp Met Glu Met Pro His 
 705                710                715                720
Tyr Ser Thr Phe Ala Tyr Pro Pro Thr Glu Val Thr Ser His Ala Phe 
                 725                730                735
Thr Pro Ser Ser Arg Pro Leu Asp Leu Ala Pro Thr Ser Asn Ile Leu 
             740                745                750
His Ser Gln Thr Thr Gln Pro Val Tyr Asn Gly Glu Thr Pro Leu Gln 
         755                760                765
Pro Ser Tyr Ser Ser Glu Val Phe Pro Leu Val Thr Pro Leu Leu Leu 
     770                775                780
Asp Asn Gln Thr Leu Asn Thr Thr Pro Ala Ala Ser Ser Ser Asp Ser 
 785                790                795                800
Ala Leu His Ala Thr Pro Val Phe Pro Ser Val Gly Val Ser Phe Asp 
                 805                810                815
Ser Ile Leu Ser Ser Tyr Asp Asp Ala Pro Leu Leu Pro Phe Ser Ser 
             820                825                830
Ala Ser Phe Ser Ser Asp Leu Phe His His Leu His Thr Val Ser Gln 
         835                840                845
Thr Leu Pro Gln Val Thr Ser Ala Ala Glu Arg Asp Glu Leu Ser Leu 
     850                855                860
His Ala Ser Leu Leu Val Ala Gly Gly Asp Leu Leu Leu Glu Pro Ser 
 865                870                875                880
Leu Val Gln Tyr Ser Asp Val Met Ser His Gln Val Thr Ile His Ala 
                 885                890                895
Ala Ser Asp Thr Leu Glu Phe Gly Ser Glu Ser Ala Val Leu Tyr Lys 
             900                905                910
Thr Ser Met Val Ser Gln Ile Glu Ser Pro Ser Ser Asp Val Val Met 
         915                920                925
His Ala Tyr Ser Ser Gly Pro Glu Thr Ser Tyr Ala Ile Glu Gly Ser 
     930                935                940
His His Val Leu Thr Val Ser Ser Ser Ser Ala Ile Pro Val His Asp 
 945                950                955                960
Ser Val Gly Val Ala Asp Gln Gly Ser Leu Leu Ile Asn Pro Ser His 
                 965                970                975
Ile Ser Leu Pro Glu Ser Ser Phe Ile Thr Pro Thr Ala Ser Leu Leu 
             980                985                990
Gln Leu Pro Pro Ala Leu Ser Gly Asp Gly Glu Trp Ser Gly Ala Ser 
         995                1000                1005
Ser Asp Ser Glu Leu Leu Leu Pro Asp Thr Asp Gly Leu Arg Thr Leu 
     1010                1015                1020
Asn Met Ser Ser Pro Val Ser Val Ala Asp Phe Thr Tyr Thr Thr Ser 
 1025                1030                1035                1040
Val Ser Gly Asp Asp Ile Lys Pro Leu Ser Lys Gly Glu Met Met Tyr 
                 1045                1050                1055
Gly Asn Glu Thr Glu Leu Lys Met Ser Ser Phe Ser Asp Met Ala Tyr 
             1060                1065                1070
Pro Ser Lys Ser Thr Val Val Pro Lys Met Ser Asp Ile Val Asn Lys 
         1075                1080                1085
Trp Ser Glu Ser Leu Lys Glu Thr Ser Val Ser Val Ser Ser Ile Asn 
     1090                1095                1100
Ser Val Phe Thr Glu Ser Leu Val Tyr Pro Ile Thr Lys Val Phe Asp 
 1105                1110                1115                1120
Gln Glu Ile Ser Arg Val Pro Glu Ile Ile Phe Pro Val Lys Pro Thr 
                 1125                1130                1135
His Thr Ala Ser Gln Ala Ser Gly Asp Thr Trp Leu Lys Pro Gly Leu 
             1140                1145                1150
Ser Thr Asn Ser Glu Pro Ala Leu Ser Asp Thr Ala Ser Ser Glu Val 
         1155                1160                1165
Ser His Pro Ser Thr Gln Pro Leu Leu Tyr Glu Ala Ala Ser Pro Phe 
     1170                1175                1180
Asn Thr Glu Ala Leu Leu Gln Pro Ser Phe Pro Ala Ser Asp Val Asp 
 1185                1190                1195                1200
Thr Leu Leu Lys Thr Ala Leu Pro Ser Gly Pro Arg Asp Pro Val Leu 
                 1205                1210                1215
Thr Glu Thr Pro Met Val Glu Gln Ser Ser Ser Ser Val Ser Leu Pro 
             1220                1225                1230
Leu Ala Ser Glu Ser Ala Ser Ser Lys Ser Thr Leu His Phe Thr Ser 
         1235                1240                1245
Val Pro Val Leu Asn Met Ser Pro Ser Asp Val His Pro Thr Ser Leu 
     1250                1255                1260
Gln Arg Leu Thr Val Pro His Ser Arg Glu Glu Tyr Phe Glu Gln Gly 
 1265                1270                1275                1280
Leu Leu Lys Ser Lys Ser Pro Gln Gln Val Leu Pro Ser Leu His Ser 
                 1285                1290                1295
His Asp Glu Phe Phe Gln Thr Ala His Leu Asp Ile Ser Gln Ala Tyr 
             1300                1305                1310
Pro Pro Lys Gly Arg His Ala Phe Ala Thr Pro Ile Leu Ser Ile Asn 
         1315                1320                1325
Glu Pro Gln Asn Thr Leu Ile Asn Arg Leu Val Tyr Ser Glu Asp Ile 
     1330                1335                1340
Phe Met His Pro Glu Ile Ser Ile Thr Asp Lys Ala Leu Thr Gly Leu 
 1345                1350                1355                1360
Pro Thr Thr Val Ser Asp Val Leu Ile Ala Thr Asp His Ser Val Pro 
                 1365                1370                1375
Leu Gly Ser Gly Pro Ile Ser Met Thr Thr Val Ser Pro Asn Arg Asp 
             1380                1385                1390
Asp Ser Val Thr Thr Thr Lys Leu Leu Leu Pro Ser Lys Ala Thr Ser 
         1395                1400                1405
Lys Pro Thr His Ser Ala Arg Ser Asp Ala Asp Leu Val Gly Gly Gly 
     1410                1415                1420
Glu Asp Gly Asp Asp Tyr Asp Asp Asp Asp Tyr Asp Asp Ile Asp Ser 
 1425                1430                1435                1440
Asp Arg Phe Pro Val Asn Lys Cys Met Ser Cys Ser Pro Tyr Arg Glu 
                 1445                1450                1455
Ser Gln Glu Lys Val Met Asn Asp Ser Asp Thr Gln Glu Ser Ser Leu 
             1460                1465                1470
Val Asp Gln Ser Asp Pro Ile Ser His Leu Leu Ser Glu Asn Thr Glu 
         1475                1480                1485
Glu Glu Asn Gly Gly Thr Gly Val Thr Arg Val Asp Lys Ser Pro Asp 
     1490                1495                1500
Lys Ser Pro Pro Pro Ser Met Leu Pro Gln Lys His Asn Asp Gly Arg 
 1505                1510                1515                1520
Glu Asp Arg Asp Ile Gln Met Gly Ser Ala Val Leu Pro His Thr Pro 
                 1525                1530                1535
Gly Ser Lys Ala Trp Ala Val Leu Thr Ser Asp Glu Glu Ser Gly Ser 
             1540                1545                1550
Gly Gln Gly Thr Ser Asp Ser Leu Asn Asp Asn Glu Thr Ser Thr Asp 
         1555                1560                1565
Phe Ser Phe Pro Asp Val Asn Glu Lys Asp Ala Asp Gly Val Leu Glu 
     1570                1575                1580
Ala Asp Asp Thr Gly Ile Ala Pro Gly Ser Pro Arg Ser Ser Thr Pro 
 1585                1590                1595                1600
Ser Val Thr Ser Gly His Ser Gly Val Ser Asn Ser Ser Glu Ala Glu 
                 1605                1610                1615
Ala Ser Asn Ser Ser His Glu Ser Arg Ile Gly Leu Ala Glu Gly Leu 
             1620                1625                1630
Glu Ser Glu Lys Lys Ala Val Ile Pro Leu Val Ile Val Ser Ala Leu 
         1635                1640                1645
Thr Phe Ile Cys Leu Val Val Leu Val Gly Ile Leu Ile Tyr Trp Arg 
     1650                1655                1660
Lys Cys Phe Gln Thr Ala His Phe Tyr Leu Glu Asp Asn Thr Ser Pro 
 1665                1670                1675                1680
Arg Val Ile Ser Thr Pro Pro Thr Pro Ile Phe Pro Ile Ser Asp Asp 
                 1685                1690                1695
Ile Gly Ala Ile Pro Ile Lys His Phe Pro Lys His Val Ala Asp Leu 
             1700                1705                1710
His Ala Ser Asn Gly Phe Thr Glu Glu Phe Glu Thr Leu Lys Glu Phe 
         1715                1720                1725
Tyr Gln Glu Val Gln Ser Cys Thr Val Asp Leu Gly Ile Thr Ala Asp 
     1730                1735                1740
Ser Ser Asn His Pro Asp Asn Lys His Lys Asn Arg Tyr Val Asn Ile 
 1745                1750                1755                1760
Val Ala Tyr Asp His Ser Arg Val Lys Leu Thr Gln Leu Ala Glu Lys 
                 1765                1770                1775
Asp Gly Lys Leu Thr Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr 
             1780                1785                1790
Asn Arg Pro Lys Ala Tyr Ile Ala Ala Gln Gly Pro Leu Lys Ser Thr 
         1795                1800                1805
Ala Glu Asp Phe Trp Arg Met Ile Trp Glu His Asn Val Glu Val Ile 
     1810                1815                1820
Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys Cys Asp Gln 
 1825                1830                1835                1840
Tyr Trp Pro Thr Asp Gly Ser Glu Glu Tyr Gly Ser Phe Leu Val Asn 
                 1845                1850                1855
Gln Lys Asn Val Gln Val Leu Ala Tyr Tyr Thr Val Arg Asn Phe Thr 
             1860                1865                1870
Leu Arg Asn Thr Lys Ile Lys Lys Gly Ser Gln Lys Gly Arg Ser Ser 
         1875                1880                1885
Gly Arg Leu Val Thr Gln Tyr His Tyr Thr Gln Trp Pro Asp Met Gly 
     1890                1895                1900
Val Pro Glu Tyr Ser Leu Pro Val Leu Ala Phe Val Arg Lys Thr Ala 
 1905                1910                1915                1920
Gln Ala Lys Arg His Ala Val Gly Pro Val Val Val His Cys Ser Ala 
                 1925                1930                1935
Gly Val Gly Arg Thr Gly Thr Tyr Ile Val Leu Asp Ser Met Leu Gln 
             1940                1945                1950
Gln Ile Gln His Glu Gly Thr Val Asn Ile Phe Gly Phe Leu Lys His 
         1955                1960                1965
Ile Arg Ser Gln Arg Asn Tyr Leu Val Gln Thr Glu Glu Gln Tyr Val 
     1970                1975                1980
Phe Ile His Asp Thr Leu Val Glu Ala Ile Leu Ser Lys Glu Thr Glu 
 1985                1990                1995                2000
Val Pro Asp Ser His Ile His Ser Tyr Val Asn Thr Leu Leu Ile Pro 
                 2005                2010                2015
Gly Pro Ser Gly Lys Thr Lys Leu Glu Lys Gln Phe Gln Leu Leu Ser 
             2020                2025                2030
Gln Ser Asn Ile Leu Gln Ser Asp Tyr Ser Thr Ala Leu Lys Gln Cys 
         2035                2040                2045
Asn Arg Glu Lys Asn Arg Thr Ser Ser Ile Ile Pro Val Glu Arg Ser 
     2050                2055                2060
Arg Val Gly Ile Ser Ser Leu Ser Gly Glu Gly Thr Asp Tyr Ile Asn 
 2065                2070                2075                2080
Ala Ser Tyr Ile Met Gly Tyr Tyr Gln Ser Asn Glu Phe Ile Ile Thr 
                 2085                2090                2095
Gln His Pro Leu Leu His Thr Ile Lys Asp Phe Trp Arg Met Ile Trp 
             2100                2105                2110
Asp His Asn Ala Gln Leu Val Val Met Ile Pro Asp Gly Gln Asn Met 
         2115                2120                2125
Ala Glu Asp Glu Phe Val Tyr Trp Pro Asn Lys Asp Glu Pro Ile Asn 
     2130                2135                2140
Cys Glu Ser Phe Lys Val Thr Leu Met Ser Glu Glu His Lys Cys Leu 
 2145                2150                2155                2160
Ser Asn Glu Glu Lys Leu Ile Val Gln Asp Phe Ile Leu Glu Ala Thr 
                 2165                2170                2175
Gln Asp Asp Tyr Val Leu Glu Val Arg His Phe Gln Cys Pro Lys Trp 
             2180                2185                2190
Pro Asn Pro Asp Ser Pro Ile Ser Lys Thr Phe Glu Leu Ile Ser Ile 
         2195                2200                2205
Ile Lys Glu Glu Ala Ala Asn Arg Asp Gly Pro Met Ile Val His Asp 
     2210                2215                2220
Glu His Gly Gly Val Thr Ala Gly Thr Phe Cys Ala Leu Thr Thr Leu 
 2225                2230                2235                2240
Met His Gln Leu Glu Lys Glu Asn Ser Met Asp Val Tyr Gln Val Ala 
                 2245                2250                2255
Lys Met Ile Asn Leu Met Arg Pro Gly Val Phe Thr Asp Ile Glu Gln 
             2260                2265                2270
Tyr Gln Phe Leu Tyr Lys Val Val Leu Ser Leu Val Ser Thr Arg Gln 
         2275                2280                2285
Glu Glu Asn Pro Ser Thr Ser Leu Asp Ser Asn Gly Ala Ala Leu Pro 
     2290                2295                2300
Asp Gly Asn Ile Ala Glu Ser Leu Glu Ser Leu Val 
 2305                2310                2315



<210> 7966
<211> 7941
<212> DNA
<213> Homo sapiens
<308> M93426
<400> 7966

cacacatac  cacgcacga  ctcacttcg  tctatacac  ggaggatta  aacaaacaa  60
caaaaaaaa  atttccttc  ctccccctc  ctctccact  tgagaagca  aggagccgc  120
cggcgaggg  ccgcagacc  tctggaaat  cgaatccta  agcgtttcc  cgcttgcat  180
cagctcctc  gtgtttgcc  cctggattg  gctaatgga  actacagac  acagagaaa  240
cttgttgaa  agattggct  gtcctatac  ggagcactg  atcaaaaaa  ttggggaaa  300
aaatatcca  catgtaata  cccaaaaca  tctcctatc  atattgatg  agatcttac  360
caagtaaat  tgaatctta  gaaacttaa  tttcagggt  gggataaaa  atcattgga  420
aacacattc  ttcataaca  tgggaaaac  gtggaaatt  atctcacta  tgactaccg  480
gtcagcgga  gagtttcag  aatggtgtt  aaagcaagc  agataactt  tcactgggg  540
aaatgcaat  tgtcatctg  tggatcaga  catagttta  aaggacaaa  atttccact  600
gagatgcaa  tctactgct  tgatgcgga  cgattttca  gttttgagg  agcagtcaa  660
ggaaaaggg  agttaagag  tttatccat  ttgtttgag  ttgggacag  agaaaattt  720
gatttcaaa  cgattattg  tggagtcga  agtgttagt  gttttggga  gcaggctgc  780
ttagatcca  tcatactgt  gaaccttct  ccaaactca  ctgacaagt  ttacattta  840
aatggctca  tgacatctc  tccctgcac  gacacagtt  actggattg  ttttaaaga  900
acagttagc  tctctgaaa  ccagttggc  gttttttgt  aagttctta  aatgcaaca  960
tctggttat  tcatgctga  ggactactt  caaaacaat  ttcgagagc  acagtacaa  1020
ttctctaga  aggtgtttt  ctcatacac  ggaaaggaa  agattcatg  agcagtttg  1080
agttcagaa  cagaaaatg  tcaggctga  ccagagaat  ataccagcc  tcttgttac  1140
tgggaaaga  ctcgagtcg  ttatgatac  atgattgag  agtttgcag  tttgtacca  1200
cagttggat  gagaggacc  aaccaagca  gaatttttg  cagatggct  tcaagactt  1260
ggtgctatt  tcaataatt  gctacccaa  atgagttat  ttcttcaga  agtagccat  1320
tgcactaat  gcttatatg  aaaatacag  gaccaactg  ttgtcgaca  gcctactga  1380
aatcctgaa  ttgatcttt  ccctgaatt  attggaact  aagaaataa  caaggagga  1440
gaagaggga  aagacattg  agaaggcgc  attgtgaat  ctggtagag  cagtgctac  1500
aaccaaatc  ggaaaaagg  accccagat  tctaccaca  cacactaca  tcgcatagg  1560
acgaaatac  atgaagcca  gactaaccg  tccccaaca  gaggaagtg  attctctgg  1620
aagggtgat  ttcccaata  atctttaaa  tccacttcc  aaccagtca  taaattagc  1680
acagaaaaa  atatttcct  gacttctca  actgtgact  aactgccac  tcacactgt  1740
gaaggtact  cagcctctt  aaatgatgg  tctaaaact  ttcttagat  tccacatat  1800
aacttgtcg  ggactgcag  atccttaaa  acagtttct  taacagaat  tgaggagga  1860
agtttattg  ccagtttca  gcttgatac  ggagctgaa  attcttcag  ctccagtcc  1920
gcaacttct  ctatcccat  catctctga  aacatatcc  aagggtata  attttcctc  1980
gaaaaccca  agacaataa  atatgatgt  cttatacca  aatctgcta  aaatgcttc  2040
gaagattca  cttcatcag  ttcagaaga  tcactaaag  atccttcta  ggagggaaa  2100
gtgtggttt  ctagctcta  agacataac  gcacagccc  atgttggat  aggcagaga  2160
agctttctc  agactaatt  cactgagat  cgtgttgat  aatctgaga  gacaaccaa  2220
tccttttct  caggcccag  gatgtcaca  ggtccctca  ttacagatc  ggaaatgcc  2280
cattattct  cctttgcct  cttcccaac  gaggtaaca  ctcatgctt  taccccatc  2340
tccagacaa  aggatttgg  ctccacggt  aacgtggta  actcgcaga  aacccaacc  2400
gtatacaat  gtgagacac  tcttcaacc  tcctacagt  gtgaagtct  tcctctagt  2460
acccctttg  tgcttgaca  tcagatcct  aacactacc  ctgctgctt  aagtagtga  2520
tcggccttg  atgctacgc  tgtatttcc  agtgtcgat  tgtcatttg  atccatcct  2580
tcttcctat  atggtgcac  tttgcttcc  ttttcctct  cttccttca  tagtgaatt  2640
tttcgccat  tgcatacag  ttctcaaat  cttccacaa  ttacttcag  taccgagag  2700
gataaggtg  ccttgcatg  ttctctgcc  gtggctggg  gtgatttgc  attagagcc  2760
agccttgct  agtattctg  tgtgctgtc  actactcat  ctgcttcag  gacgctgga  2820
tttggtagt  aatctggtg  tctttataa  acgcttatg  tttctcaag  tgaaccacc  2880
agcagtgat  ccatgatgc  tgcacgttc  tcagggcct  aaccttctt  tgccttgtc  2940
gataatgag  gctcccaac  catcttcac  gtttcttac  gttctgcaa  acctgtgca  3000
gattctgtg  gtgtaactt  tcagggttc  ttatttagc  gccctagcc  tataccaat  3060
cctaagtct  cgttaataa  cccaactgc  tcattactg  agcctactc  tgccctctc  3120
ggtgatggg  aatggtctg  agcctcttc  gatagtgaa  ttcttttac  tgacacaga  3180
gggctgaca  cccttaaca  ttcttcacc  gtttctgta  ctgaattta  atatacaac  3240
tctgtgttt  gtgatgata  taaggcgct  tctaaaagt  aaataatat  tggaaatga  3300
actgaactg  aaattcctt  tttcaatga  atggtttac  cttctgaaa  cacagtcat  3360
cccaacatg  atgataatg  aaataagtt  aatgcgtct  tacaagaaa  ctctgtttc  3420
atttctagc  ccaagggca  gtttccagg  tcccttgct  ataccacca  taaggtttt  3480
gatcatgag  ttagtcaag  tccagaaaa  aacttttca  ttcaaccta  acatactgt  3540
tctcaagca  ctggtgaca  ttcgcttaa  cctgtgctt  gtgcaaact  agagccagc  3600
tcctctgac  ctgcttcta  tgaaatgtt  tctccttca  ctcagctct  attttatga  3660
acctcagct  cttttagta  tgaagtatt  ctacaacct  cctttcagg  ttctgatgt  3720
gacaccttg  ttaaaactg  tcttccagc  gtgcccagt  atccaatat  ggttgaaac  3780
cccaaagtt  ataaaatta  ttctacaat  ttgcatctc  ttgtatcaa  ttctgcttc  3840
agtgaaaac  tgctgcact  tacatctgt  ccagttttt  atgtgtcgc  tacttctca  3900
atgcactct  cttcacttc  aggtttgac  atttcctat  caagtgaga  atatgaacc  3960
gttttgtta  aaagtgaaa  ttcccacca  gtggtacct  ctttgtaca  taatgatga  4020
ttgttccaa  cggccaatt  ggagattaa  caggcccat  ccccaaaag  aaggcatgt  4080
tttgctaca  ctgttttat  aattgatga  ccattaaat  cactaataa  taagcttat  4140
cattccgat  aaattttaa  ctccaccaa  agttctgtt  ctggtaagg  atttgctgg  4200
attccaaca  ttgcttctg  tacatttgt  tctactgat  attctgttc  tataggaaa  4260
gggcatgtt  ccattacag  tgtttctcc  cacagagat  gttctgtaa  ctcaacaaa  4320
ttgctgttt  cttctaagg  aacttctga  ctgagtcat  gtgccaaat  tgatgccgg  4380
ttagtgggt  gtggtgaag  tggtgacac  gatgatgat  gtgatgatg  tgatgacag  4440
gatagtgat  gcttatcca  tcataagtg  atgtcatgc  catcctata  agaatcaca  4500
gaaaaggta  tgaatgatt  agacaccca  gaaaacagt  ttatggatc  gaataatcc  4560
atctcatac  cactatctg  gaattctga  gaagataat  gagtcacaa  tgtatcctc  4620
gacagtcaa  ctggtatgg  cagaagtcc  ggtaaatca  catcagcaa  tgggctatc  4680
caaaagcac  atgatggaa  agaggaaaa  gacattcag  ctggtagtg  tctgcttcc  4740
ctcagccct  aatctaaag  atgggcagt  ctgacaagt  atgaagaaa  tggatcagg  4800
caaggtacc  cagatagcc  taatgagaa  gagacttcc  cagatttca  ttttgcaga  4860
actaatgaa  aagatgctg  tgggatcct  gcagcaggt  actcagaaa  aactcctgg  4920
ttcccacag  ccccaacat  atctgttac  agcgagaac  cagaagtgt  ccacgtttc  4980
gaggcagag  ccagtaata  tagccatga  tctcgtatt  gtctagctg  ggggttgga  5040
tccgagaag  aggcagtta  accccttgt  atcgtgtca  ccctgactt  tatctgtct  5100
gtggttctt  tgggtattc  catctactg  aggaaatgc  tccagactg  acactttta  5160
ttagaggac  gtacatccc  tagagttat  tccacacct  caacaccta  ctttccaat  5220
tcagatgat  tcggagcaa  tccaataaa  cactttcca  agcatgttg  agatttaca  5280
gcaagtagt  ggtttactg  agaatttga  acactgaaa  agttttacc  ggaagtgca  5340
agctgtact  ttgacttag  tattacagc  gacagctcc  accacccag  caacaagca  5400
aagaatcga  acataaata  cgttgccta  gatcatagc  gggttaagc  agcacagct  5460
gctgaaaag  atggcaaac  gactgatta  atcaatgcc  attatgttg  tggctacaa  5520
agaccaaaa  cttatattg  tgcccaagg  ccactgaaa  ccacagctg  agatttctg  5580
agaatgata  gggaacata  tgtggaagt  attgtcatg  taacaaacc  cgtggagaa  5640
ggaaggaga  aatgtgatc  gtactggcc  gccgatggg  gtgaggagt  cgggaactt  5700
ctggtcact  agaagagtg  gcaagtgct  gcctattat  ctgtgagga  ttttactct  5760
agaaacaca  aaataaaaa  gggctccca  aaaggaaga  ccagtggac  tgtggtcac  5820
cagtatcac  acacgcagt  gcctgacat  ggagtacca  agtactccc  gccagtgct  5880
acctttgtg  gaaaggcag  ctatgccaa  cgccatgca  tggggcctg  tgtcgtcca  5940
tgcagtgct  gagttggaa  aacaggcac  tatattgtg  tagacagta  gttgcagca  6000
attcaacac  aaggaactg  caacatatt  ggcttctta  aacacatcc  ttcacaaag  6060
aattatttg  tacaaactg  ggagcaata  gtcttcatt  atgatacac  ggttgaggc  6120
atacttagt  aagaaactg  ggtgctgga  agtcatatt  atgcctatg  taatgcact  6180
ctcattcct  gaccagcag  caaaacaaa  ctagagaaa  aattccagc  cctgagcca  6240
tcaaatata  agcagagtg  ctattctgc  gccctaaag  aatgcaaca  ggaaaagaa  6300
cgaacttct  ctatcatcc  tgtggaaag  tcaagggtt  gcatttcat  cctgagtgg  6360
gaaggcaca  actacatca  tgcctccta  atcatgggc  attaccaga  caatgaatt  6420
atcattacc  agcaccctc  ccttcatac  atcaaggat  tctggagga  gatatggga  6480
cataatgcc  aactggtgg  tatgattcc  gatggccaa  acatggcag  agatgaatt  6540
gtttactgg  caaataaag  tgagcctat  aattgtgag  gctttaagg  cactcttat  6600
gctgaagaa  acaaatgtc  atctaatga  gaaaaactt  taattcagg  ctttatctt  6660
gaagctaca  aggatgatt  tgtacttga  gtgaggcac  ttcagtgtc  taaatggcc  6720
aatccagat  gccccatta  taaaacttt  gaacttata  gtgttataa  agaagaagc  6780
gccaatagg  atgggccta  gattgttca  gatgagcat  gaggagtga  ggcaggaac  6840
ttctgtgct  tgacaaccc  tatgcacca  ctagaaaaa  aaaattccg  ggatgttta  6900
caggtagcc  agatgatca  tctgatgag  ccaggagtc  ttgctgaca  tgagcagta  6960
cagtttctc  acaaagtga  cctcagcct  gtgagcaca  ggcaggaag  gaatccatc  7020
acctctctg  acagtaatg  tgcagcatt  cctgatgga  atatagctg  gagcttaga  7080
tctttagtt  aacacagaa  ggggtgggg  gactcacat  tgagcattg  tttcctctt  7140
ctaaaatta  gcaggaaaa  cagtctagt  ctgttatct  ttgatttcc  atcacctga  7200
agtaacttt  atgacatag  attctgccg  caaatttat  tcattaaca  tgtgtgcct  7260
tttgcaaga  ttgtaattt  cttattatg  ttgaactaa  atgattgaa  tttacagta  7320
ttctaagaa  ggaattgtg  tattttttt  tgtattgat  ttaacagaa  atttcaatt  7380
atagaggtt  ggaattcca  actacagaa  atgtttgtt  ttagtgtca  atttttagc  7440
gtatttgta  caattatca  gtttgctag  aatataact  ttaatacag  agcctgtaa  7500
taaaacact  ttccatatg  tattcaaca  tttacaact  cagtattca  ctaaagtag  7560
aataatctg  tacttattg  aaatactgc  ctagtgtct  catggacca  atttatatt  7620
ataattgta  atttttata  tttactact  agtcaagtt  tctagttct  tgtaattgt  7680
tagtttaat  acgtagttc  ttagctggt  ttactctac  agttttctg  cattgtatt  7740
tgttaccta  gtcattaac  ttgtttcag  atgtaattt  aacttttgt  gaaaataga  7800
ataccttca  tttgaaaga  gtttttatg  gaataacac  ttaccaaac  ttgttcaaa  7860
ggtttttat  caaggaatt  caaaaataa  tataaatat  gccattaaa  aaaaaaaaa  7920
aaaaaaaaa  aaaaaaaaa  a  7941



<210> 7967
<211> 2314
<212> PRT
<213> Homo sapiens
<308> P23471
<400> 7967

Met Arg Ile Leu Lys Arg Phe Leu Ala Cys Ile Gln Leu Leu Cys Val 
  1               5                  10                  15
Cys Arg Leu Asp Trp Ala Asn Gly Tyr Tyr Arg Gln Gln Arg Lys Leu 
             20                  25                  30
Val Glu Glu Ile Gly Trp Ser Tyr Thr Gly Ala Leu Asn Gln Lys Asn 
         35                  40                  45
Trp Gly Lys Lys Tyr Pro Thr Cys Asn Ser Pro Lys Gln Ser Pro Ile 
     50                  55                  60
Asn Ile Asp Glu Asp Leu Thr Gln Val Asn Val Asn Leu Lys Lys Leu 
 65                  70                  75                  80
Lys Phe Gln Gly Trp Asp Lys Thr Ser Leu Glu Asn Thr Phe Ile His 
                 85                  90                  95
Asn Thr Gly Lys Thr Val Glu Ile Asn Leu Thr Asn Asp Tyr Arg Val 
             100                105                110
Ser Gly Gly Val Ser Glu Met Val Phe Lys Ala Ser Lys Ile Thr Phe 
         115                120                125
His Trp Gly Lys Cys Asn Met Ser Ser Asp Gly Ser Glu His Ser Leu 
     130                135                140
Glu Gly Gln Lys Phe Pro Leu Glu Met Gln Ile Tyr Cys Phe Asp Ala 
 145                150                155                160
Asp Arg Phe Ser Ser Phe Glu Glu Ala Val Lys Gly Lys Gly Lys Leu 
                 165                170                175
Arg Ala Leu Ser Ile Leu Phe Glu Val Gly Thr Glu Glu Asn Leu Asp 
             180                185                190
Phe Lys Ala Ile Ile Asp Gly Val Glu Ser Val Ser Arg Phe Gly Lys 
         195                200                205
Gln Ala Ala Leu Asp Pro Phe Ile Leu Leu Asn Leu Leu Pro Asn Ser 
     210                215                220
Thr Asp Lys Tyr Tyr Ile Tyr Asn Gly Ser Leu Thr Ser Pro Pro Cys 
 225                230                235                240
Thr Asp Thr Val Asp Trp Ile Val Phe Lys Asp Thr Val Ser Ile Ser 
                 245                250                255
Glu Ser Gln Leu Ala Val Phe Cys Glu Val Leu Thr Met Gln Gln Ser 
             260                265                270
Gly Tyr Val Met Leu Met Asp Tyr Leu Gln Asn Asn Phe Arg Glu Gln 
         275                280                285
Gln Tyr Lys Phe Ser Arg Gln Val Phe Ser Ser Tyr Thr Gly Lys Glu 
     290                295                300
Glu Ile His Glu Ala Val Cys Ser Ser Glu Pro Glu Asn Val Gln Ala 
 305                310                315                320
Asp Pro Glu Asn Tyr Thr Ser Leu Leu Val Thr Trp Glu Arg Pro Arg 
                 325                330                335
Val Val Tyr Asp Thr Met Ile Glu Lys Phe Ala Val Leu Tyr Gln Gln 
             340                345                350
Leu Asp Gly Glu Asp Gln Thr Lys His Glu Phe Leu Thr Asp Gly Tyr 
         355                360                365
Gln Asp Leu Gly Ala Ile Leu Asn Asn Leu Leu Pro Asn Met Ser Tyr 
     370                375                380
Val Leu Gln Ile Val Ala Ile Cys Thr Asn Gly Leu Tyr Gly Lys Tyr 
 385                390                395                400
Ser Asp Gln Leu Ile Val Asp Met Pro Thr Asp Asn Pro Glu Leu Asp 
                 405                410                415
Leu Phe Pro Glu Leu Ile Gly Thr Glu Glu Ile Ile Lys Glu Glu Glu 
             420                425                430
Glu Gly Lys Asp Ile Glu Glu Gly Ala Ile Val Asn Pro Gly Arg Asp 
         435                440                445
Ser Ala Thr Asn Gln Ile Arg Lys Lys Glu Pro Gln Ile Ser Thr Thr 
     450                455                460
Thr His Tyr Asn Arg Ile Gly Thr Lys Tyr Asn Glu Ala Lys Thr Asn 
 465                470                475                480
Arg Ser Pro Thr Arg Gly Ser Glu Phe Ser Gly Lys Gly Asp Val Pro 
                 485                490                495
Asn Thr Ser Leu Asn Ser Thr Ser Gln Pro Val Thr Lys Leu Ala Thr 
             500                505                510
Glu Lys Asp Ile Ser Leu Thr Ser Gln Thr Val Thr Glu Leu Pro Pro 
         515                520                525
His Thr Val Glu Gly Thr Ser Ala Ser Leu Asn Asp Gly Ser Lys Thr 
     530                535                540
Val Leu Arg Ser Pro His Met Asn Leu Ser Gly Thr Ala Glu Ser Leu 
 545                550                555                560
Asn Thr Val Ser Ile Thr Glu Tyr Glu Glu Glu Ser Leu Leu Thr Ser 
                 565                570                575
Phe Lys Leu Asp Thr Gly Ala Glu Asp Ser Ser Gly Ser Ser Pro Ala 
             580                585                590
Thr Ser Ala Ile Pro Phe Ile Ser Glu Asn Ile Ser Gln Gly Tyr Ile 
         595                600                605
Phe Ser Ser Glu Asn Pro Glu Thr Ile Thr Tyr Asp Val Leu Ile Pro 
     610                615                620
Glu Ser Ala Arg Asn Ala Ser Glu Asp Ser Thr Ser Ser Gly Ser Glu 
 625                630                635                640
Glu Ser Leu Lys Asp Pro Ser Met Glu Gly Asn Val Trp Phe Pro Ser 
                 645                650                655
Ser Thr Asp Ile Thr Ala Gln Pro Asp Val Gly Ser Gly Arg Glu Ser 
             660                665                670
Phe Leu Gln Thr Asn Tyr Thr Glu Ile Arg Val Asp Glu Ser Glu Lys 
         675                680                685
Thr Thr Lys Ser Phe Ser Ala Gly Pro Val Met Ser Gln Gly Pro Ser 
     690                695                700
Val Thr Asp Leu Glu Met Pro His Tyr Ser Thr Phe Ala Tyr Phe Pro 
 705                710                715                720
Thr Glu Val Thr Pro His Ala Phe Thr Pro Ser Ser Arg Gln Gln Asp 
                 725                730                735
Leu Val Ser Thr Val Asn Val Val Tyr Ser Gln Thr Thr Gln Pro Val 
             740                745                750
Tyr Asn Gly Glu Thr Pro Leu Gln Pro Ser Tyr Ser Ser Glu Val Phe 
         755                760                765
Pro Leu Val Thr Pro Leu Leu Leu Asp Asn Gln Ile Leu Asn Thr Thr 
     770                775                780
Pro Ala Ala Ser Ser Ser Asp Ser Ala Leu His Ala Thr Pro Val Phe 
 785                790                795                800
Pro Ser Val Asp Val Ser Phe Glu Ser Ile Leu Ser Ser Tyr Asp Gly 
                 805                810                815
Ala Pro Leu Leu Pro Phe Ser Ser Ala Ser Phe Ser Ser Glu Leu Phe 
             820                825                830
Arg His Leu His Thr Val Ser Gln Ile Leu Pro Gln Val Thr Ser Ala 
         835                840                845
Thr Glu Ser Asp Lys Val Pro Leu His Ala Ser Leu Pro Val Ala Gly 
     850                855                860
Gly Asp Leu Leu Leu Glu Pro Ser Leu Ala Gln Tyr Ser Asp Val Leu 
 865                870                875                880
Ser Thr Thr His Ala Ala Ser Glu Thr Leu Glu Phe Gly Ser Glu Ser 
                 885                890                895
Gly Val Leu Tyr Lys Thr Leu Met Phe Ser Gln Val Glu Pro Pro Ser 
             900                905                910
Ser Asp Ala Met Met His Ala Arg Ser Ser Gly Pro Glu Pro Ser Tyr 
         915                920                925
Ala Leu Ser Asp Asn Glu Gly Ser Gln His Ile Phe Thr Val Ser Tyr 
     930                935                940
Ser Ser Ala Ile Pro Val His Asp Ser Val Gly Val Thr Tyr Gln Gly 
 945                950                955                960
Ser Leu Phe Ser Gly Pro Ser His Ile Pro Ile Pro Lys Ser Ser Leu 
                 965                970                975
Ile Thr Pro Thr Ala Ser Leu Leu Gln Pro Thr His Ala Leu Ser Gly 
             980                985                990
Asp Gly Glu Trp Ser Gly Ala Ser Ser Asp Ser Glu Phe Leu Leu Pro 
         995                1000                1005
Asp Thr Asp Gly Leu Thr Ala Leu Asn Ile Ser Ser Pro Val Ser Val 
     1010                1015                1020
Ala Glu Phe Thr Tyr Thr Thr Ser Val Phe Gly Asp Asp Asn Lys Ala 
 1025                1030                1035                1040
Leu Ser Lys Ser Glu Ile Ile Tyr Gly Asn Glu Thr Glu Leu Gln Ile 
                 1045                1050                1055
Pro Ser Phe Asn Glu Met Val Tyr Pro Ser Glu Ser Thr Val Met Pro 
             1060                1065                1070
Asn Met Tyr Asp Asn Val Asn Lys Leu Asn Ala Ser Leu Gln Glu Thr 
         1075                1080                1085
Ser Val Ser Ile Ser Ser Thr Lys Gly Met Phe Pro Gly Ser Leu Ala 
     1090                1095                1100
His Thr Thr Thr Lys Val Phe Asp His Glu Ile Ser Gln Val Pro Glu 
 1105                1110                1115                1120
Asn Asn Phe Ser Val Gln Pro Thr His Thr Val Ser Gln Ala Ser Gly 
                 1125                1130                1135
Asp Thr Ser Leu Lys Pro Val Leu Ser Ala Asn Ser Glu Pro Ala Ser 
             1140                1145                1150
Ser Asp Pro Ala Ser Ser Glu Met Leu Ser Pro Ser Thr Gln Leu Leu 
         1155                1160                1165
Phe Tyr Glu Thr Ser Ala Ser Phe Ser Thr Glu Val Leu Leu Gln Pro 
     1170                1175                1180
Ser Phe Gln Ala Ser Asp Val Asp Thr Leu Leu Lys Thr Val Leu Pro 
 1185                1190                1195                1200
Ala Val Pro Ser Asp Pro Ile Leu Val Glu Thr Pro Lys Val Asp Lys 
                 1205                1210                1215
Ile Ser Ser Thr Met Leu His Leu Ile Val Ser Asn Ser Ala Ser Ser 
             1220                1225                1230
Glu Asn Met Leu His Ser Thr Ser Val Pro Val Phe Asp Val Ser Pro 
         1235                1240                1245
Thr Ser His Met His Ser Ala Ser Leu Gln Gly Leu Thr Ile Ser Tyr 
     1250                1255                1260
Ala Ser Glu Lys Tyr Glu Pro Val Leu Leu Lys Ser Glu Ser Ser His 
 1265                1270                1275                1280
Gln Val Val Pro Ser Leu Tyr Ser Asn Asp Glu Leu Phe Gln Thr Ala 
                 1285                1290                1295
Asn Leu Glu Ile Asn Gln Ala His Pro Pro Lys Gly Arg His Val Phe 
             1300                1305                1310
Ala Thr Pro Val Leu Ser Ile Asp Glu Pro Leu Asn Thr Leu Ile Asn 
         1315                1320                1325
Lys Leu Ile His Ser Asp Glu Ile Leu Thr Ser Thr Lys Ser Ser Val 
     1330                1335                1340
Thr Gly Lys Val Phe Ala Gly Ile Pro Thr Val Ala Ser Asp Thr Phe 
 1345                1350                1355                1360
Val Ser Thr Asp His Ser Val Pro Ile Gly Asn Gly His Val Ala Ile 
                 1365                1370                1375
Thr Ala Val Ser Pro His Arg Asp Gly Ser Val Thr Ser Thr Lys Leu 
             1380                1385                1390
Leu Phe Pro Ser Lys Ala Thr Ser Glu Leu Ser His Ser Ala Lys Ser 
         1395                1400                1405
Asp Ala Gly Leu Val Gly Gly Gly Glu Asp Gly Asp Thr Asp Asp Asp 
     1410                1415                1420
Gly Asp Asp Asp Asp Asp Arg Asp Ser Asp Gly Leu Ser Ile His Lys 
 1425                1430                1435                1440
Cys Met Ser Cys Ser Ser Tyr Arg Glu Ser Gln Glu Lys Val Met Asn 
                 1445                1450                1455
Asp Ser Asp Thr His Glu Asn Ser Leu Met Asp Gln Asn Asn Pro Ile 
             1460                1465                1470
Ser Tyr Ser Leu Ser Glu Asn Ser Glu Glu Asp Asn Arg Val Thr Ser 
         1475                1480                1485
Val Ser Ser Asp Ser Gln Thr Gly Met Asp Arg Ser Pro Gly Lys Ser 
     1490                1495                1500
Pro Ser Ala Asn Gly Leu Ser Gln Lys His Asn Asp Gly Lys Glu Glu 
 1505                1510                1515                1520
Asn Asp Ile Gln Thr Gly Ser Ala Leu Leu Pro Leu Ser Pro Glu Ser 
                 1525                1530                1535
Lys Ala Trp Ala Val Leu Thr Ser Asp Glu Glu Ser Gly Ser Gly Gln 
             1540                1545                1550
Gly Thr Ser Asp Ser Leu Asn Glu Asn Glu Thr Ser Thr Asp Phe Ser 
         1555                1560                1565
Phe Ala Asp Thr Asn Glu Lys Asp Ala Asp Gly Ile Leu Ala Ala Gly 
     1570                1575                1580
Asp Ser Glu Ile Thr Pro Gly Phe Pro Gln Ser Pro Thr Ser Ser Val 
 1585                1590                1595                1600
Thr Ser Glu Asn Ser Glu Val Phe His Val Ser Glu Ala Glu Ala Ser 
                 1605                1610                1615
Asn Ser Ser His Glu Ser Arg Ile Gly Leu Ala Glu Gly Leu Glu Ser 
             1620                1625                1630
Glu Lys Lys Ala Val Ile Pro Leu Val Ile Val Ser Ala Leu Thr Phe 
         1635                1640                1645
Ile Cys Leu Val Val Leu Val Gly Ile Leu Ile Tyr Trp Arg Lys Cys 
     1650                1655                1660
Phe Gln Thr Ala His Phe Tyr Leu Glu Asp Ser Thr Ser Pro Arg Val 
 1665                1670                1675                1680
Ile Ser Thr Pro Pro Thr Pro Ile Phe Pro Ile Ser Asp Asp Val Gly 
                 1685                1690                1695
Ala Ile Pro Ile Lys His Phe Pro Lys His Val Ala Asp Leu His Ala 
             1700                1705                1710
Ser Ser Gly Phe Thr Glu Glu Phe Glu Thr Leu Lys Glu Phe Tyr Gln 
         1715                1720                1725
Glu Val Gln Ser Cys Thr Val Asp Leu Gly Ile Thr Ala Asp Ser Ser 
     1730                1735                1740
Asn His Pro Asp Asn Lys His Lys Asn Arg Tyr Ile Asn Ile Val Ala 
 1745                1750                1755                1760
Tyr Asp His Ser Arg Val Lys Leu Ala Gln Leu Ala Glu Lys Asp Gly 
                 1765                1770                1775
Lys Leu Thr Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr Asn Arg 
             1780                1785                1790
Pro Lys Ala Tyr Ile Ala Ala Gln Gly Pro Leu Lys Ser Thr Ala Glu 
         1795                1800                1805
Asp Phe Trp Arg Met Ile Trp Glu His Asn Val Glu Val Ile Val Met 
     1810                1815                1820
Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys Cys Asp Gln Tyr Trp 
 1825                1830                1835                1840
Pro Ala Asp Gly Ser Glu Glu Tyr Gly Asn Phe Leu Val Thr Gln Lys 
                 1845                1850                1855
Ser Val Gln Val Leu Ala Tyr Tyr Thr Val Arg Asn Phe Thr Leu Arg 
             1860                1865                1870
Asn Thr Lys Ile Lys Lys Gly Ser Gln Lys Gly Arg Pro Ser Gly Arg 
         1875                1880                1885
Val Val Thr Gln Tyr His Tyr Thr Gln Trp Pro Asp Met Gly Val Pro 
     1890                1895                1900
Glu Tyr Ser Leu Pro Val Leu Thr Phe Val Arg Lys Ala Ala Tyr Ala 
 1905                1910                1915                1920
Lys Arg His Ala Val Gly Pro Val Val Val His Cys Ser Ala Gly Val 
                 1925                1930                1935
Gly Arg Thr Gly Thr Tyr Ile Val Leu Asp Ser Met Leu Gln Gln Ile 
             1940                1945                1950
Gln His Glu Gly Thr Val Asn Ile Phe Gly Phe Leu Lys His Ile Arg 
         1955                1960                1965
Ser Gln Arg Asn Tyr Leu Val Gln Thr Glu Glu Gln Tyr Val Phe Ile 
     1970                1975                1980
His Asp Thr Leu Val Glu Ala Ile Leu Ser Lys Glu Thr Glu Val Leu 
 1985                1990                1995                2000
Asp Ser His Ile His Ala Tyr Val Asn Ala Leu Leu Ile Pro Gly Pro 
                 2005                2010                2015
Ala Gly Lys Thr Lys Leu Glu Lys Gln Phe Gln Leu Leu Ser Gln Ser 
             2020                2025                2030
Asn Ile Gln Gln Ser Asp Tyr Ser Ala Ala Leu Lys Gln Cys Asn Arg 
         2035                2040                2045
Glu Lys Asn Arg Thr Ser Ser Ile Ile Pro Val Glu Arg Ser Arg Val 
     2050                2055                2060
Gly Ile Ser Ser Leu Ser Gly Glu Gly Thr Asp Tyr Ile Asn Ala Ser 
 2065                2070                2075                2080
Tyr Ile Met Gly Tyr Tyr Gln Ser Asn Glu Phe Ile Ile Thr Gln His 
                 2085                2090                2095
Pro Leu Leu His Thr Ile Lys Asp Phe Trp Arg Met Ile Trp Asp His 
             2100                2105                2110
Asn Ala Gln Leu Val Val Met Ile Pro Asp Gly Gln Asn Met Ala Glu 
         2115                2120                2125
Asp Glu Phe Val Tyr Trp Pro Asn Lys Asp Glu Pro Ile Asn Cys Glu 
     2130                2135                2140
Ser Phe Lys Val Thr Leu Met Ala Glu Glu His Lys Cys Leu Ser Asn 
 2145                2150                2155                2160
Glu Glu Lys Leu Ile Ile Gln Asp Phe Ile Leu Glu Ala Thr Gln Asp 
                 2165                2170                2175
Asp Tyr Val Leu Glu Val Arg His Phe Gln Cys Pro Lys Trp Pro Asn 
             2180                2185                2190
Pro Asp Ser Pro Ile Ser Lys Thr Phe Glu Leu Ile Ser Val Ile Lys 
         2195                2200                2205
Glu Glu Ala Ala Asn Arg Asp Gly Pro Met Ile Val His Asp Glu His 
     2210                2215                2220
Gly Gly Val Thr Ala Gly Thr Phe Cys Ala Leu Thr Thr Leu Met His 
 2225                2230                2235                2240
Gln Leu Glu Lys Glu Asn Ser Val Asp Val Tyr Gln Val Ala Lys Met 
                 2245                2250                2255
Ile Asn Leu Met Arg Pro Gly Val Phe Ala Asp Ile Glu Gln Tyr Gln 
             2260                2265                2270
Phe Leu Tyr Lys Val Ile Leu Ser Leu Val Ser Thr Arg Gln Glu Glu 
         2275                2280                2285
Asn Pro Ser Thr Ser Leu Asp Ser Asn Gly Ala Ala Leu Pro Asp Gly 
     2290                2295                2300
Asn Ile Ala Glu Ser Leu Glu Ser Leu Val 
 2305                2310



<210> 7968
<211> 6801
<212> DNA
<213> Rattus norvegicus
<308> U04998
<400> 7968

cctagaccc  ggccagtca  cggcgtccc  tgtctcggt  ttcccactc  ctgcaccct  60
agctgtacc  ctgcggctg  cgaggggcc  cggacccgg  tggagatgc  aatcctgca  120
agcttcctc  cgtgcgttc  gctactgtg  gtgtgtcgc  tggactggg  ttatggata  180
tacagacaa  agagaaaac  tgttgaaga  attggctgg  cctatacag  agcactaaa  240
caaaaaaat  ggggaaaga  atatccaat  tgtaatagc  caaagcagt  tcctattaa  300
attgatgaa  atcttacac  agtaaatgt  aatcttaag  aactgaaat  tcagggttg  360
gaaaaacca  ccttggaaa  cacgtttat  cacaacact  ggaaaacag  ggaaataaa  420
ctcaccaat  actactatc  cagtggagg  ctttcagaa  aggtcttca  ggcaagcaa  480
atgactttt  actggggga  atgcaatgt  tcatcggaa  gatcggaac  cagcttaga  540
gggcagaag  ttccactcg  gatgcaaat  tactgcttc  atgcggacc  attttcaag  600
tttgaggaa  cagttaaag  aaaaggaag  ttaagggct  tatccattt  atttgagat  660
ggagttgaa  aaaatttgg  ttacaaagc  attattgat  ggactgaaa  tgttagtcg  720
tttggaaag  aggctgcct  agatccgtt  atcttgcag  acctcctgc  aaactccac  780
gacaagtac  acatttaca  cggatcact  acatcccct  cctgcacag  caccgtcga  840
tggattgtt  ttaaggata  agttagcat  tctgaaagc  agctggctg  attttgtga  900
gttctcaca  tgcaacagt  cgggtatgt  atgttgatg  attacttac  aaacaattt  960
cgagaacaa  agtacaagt  ttccaggca  gtgttttct  cgtacactg  gaaggaaga  1020
attcatgaa  cagtgtgca  ttcagaacc  gaaaatgtg  aagctgacc  tgagaatta  1080
accagcctt  tgatcacat  ggaaaggcc  cgggttgtt  atgacacaa  gattgagaa  1140
tttgcggtt  tgtaccagc  actggaggg  aacgaccaa  ccaagcatg  gtttttaac  1200
gatggctat  aggacttgg  tgccattct  aataactta  tacctaaca  gagttatgt  1260
ctccaaata  tggccatat  ctctaatgg  ctttatgga  agtacagtg  ccaattgat  1320
gtcgacatg  ctactgagg  tgctgaact  gacctcttt  ctgaattaa  tggaactga  1380
gaaataatc  aggaggaaa  ctatggaaa  ggcaatgaa  aagacactg  cttgaatcc  1440
ggtagagac  gtgccacaa  ccaaataag  aaaaaggaa  cccaggttt  taccacaac  1500
cactataat  acatgggga  taaatataa  gaagccaag  ctaaccgat  tccaacgag  1560
ggatctgaa  tctctggaa  gagtgatgt  ctcaacaca  ccctgaatc  tacttccca  1620
caggttgct  aattcaatc  agaaagaga  atgtccttg  cttctcaga  tggaactaa  1680
ctgccacca  acagtgtgg  aggcacctc  gcctcctta  acagtggct  taaaactct  1740
cttgtcttc  cacagatga  cttgtctgg  actgcagaa  ccttaaata  ggtttccat  1800
acagagtac  aagaggtgt  tgctgacct  agtgaggaa  aaaacttac  gactgattt  1860
aagctcgat  gtggagcag  tgattcgtc  ggctctagc  ctgcatcct  cactgtccc  1920
ttttccaca  ataatctat  ccatggata  acgtcttct  cagacacgc  cgaggcggt  1980
acgtatgat  tccttaggc  agaatctac  agaaatgct  tagaggatt  ggctccatc  2040
ggttcagaa  aatcactaa  ggatccctc  cttgaaggg  gtgtgtggt  ccctggatc  2100
acagaccta  caacacagt  tgagactgg  tctgggaga  agggctttc  ccaagttaa  2160
tccacggac  tccaagttg  tgaatcgag  gagacaact  agacatttt  tccagatgc  2220
accgcgtcc  ggggtcctt  ggtcacaga  atggaaatg  cacattatt  tacctttgc  2280
taccccccg  ctgaagtaa  atcacatgc  ttcactccg  cctccagac  acttgattt  2340
gctcccact  gcaacatcc  ccattcgca  acaactcaa  cagtataca  tggtgagac  2400
cctcttcaa  cttcctaca  tagtgaagt  tttcctcta  tcacccctt  gttgcttga  2460
aatcagacc  tcaacacta  ccctgctgc  tcaagtagt  attcggcct  gcatgctac  2520
cctgtattc  ccagtgttg  tgtgtcatt  gactccatc  tgtcttcct  tgatgatgc  2580
cctctgctc  cattttcct  tgcttcctt  agtagtgac  tgtttcacc  tctgcatac  2640
gtttctcaa  cccttccgc  agttacttc  gctgctgag  gggatgagc  gtctttgca  2700
gcttctctg  tggtggctg  gggtgattt  ctgttagag  ccagccttg  tcagtattc  2760
gatgtgatg  cacatcagg  cactattca  gctgcttcg  acacattgg  atttggtag  2820
gagtctgct  tcctttata  aacgtctat  gtttctcaa  tcgaatcac  cagcagtga  2880
gtcgttatg  atgcatatt  gtcagggcc  gaaacttct  atgccattg  gggctccca  2940
cacgtgctc  ctgtttctt  cagttctgc  atacctgtg  atgattctg  cggtgtagc  3000
gatcagggg  ccttactta  caatcctag  catatatca  tgcctgagt  ctcatttat  3060
actccaact  catcattac  gcagcttcc  cctgccctc  ctggtgatg  ggagtggtc  3120
ggagcctcc  ctgatagtg  attgctttt  cctgacaca  atgggctga  aactcttaa  3180
atgtcttca  ctgtttctg  agctgattt  acatacacg  catctgtgt  tggcgatga  3240
attaagccg  tttctaaag  tgaaatgat  tatggaaat  agaccgaac  gaaaatgtc  3300
tctttcagt  acatggcat  cccttctaa  agcacagtc  tgccaaaga  gtctgatat  3360
gtaaataag  ggagtgaat  tttaaaaga  acctctgtt  ccgtatcta  cataaacag  3420
gtgtttaca  agtctcttg  ttatcccat  actaaggtt  ttgatcagg  gattagtcg  3480
gttccagag  ttatcttcc  agttaaacc  acacacaca  catctcaag  atctggtga  3540
acttggctt  aacccgggc  tagcacaaa  tcagagcct  cgctctctg  cactgcttc  3600
agtgaagta  cacaccctt  aacacagcc  ttgctctat  aggccgcat  tccttttaa  3660
acggaagca  tgctgcaac  ttcctttcc  gcttctgat  ttgacacct  gcttaaaac  3720
gcccttccc  ctgggcctc  tgatccagt  ctgactgaa  cccccatgg  tgagcaaag  3780
agctcttcc  tatctcttc  cctggcatc  gagtctgct  caagcaaaa  cacgctgca  3840
tttacatct  taccagttc  caatatgtc  ccttctgat  tgcacccca  ttcacttca  3900
cgcttaaca  ttcctcact  gagggagga  tattttgaa  aaggtttgc  taagagcaa  3960
agtccccag  aagtcctgc  gtccttgca  agccatgac  agtttttcc  aactgcaca  4020
ctggacatt  gccaggcct  ccctccaaa  ggaaggcat  catttgcta  tcctatttt  4080
tcaatcaat  aaccacaaa  tacacttat  aacaggctt  tgtattctg  ggacatttt  4140
atgcaccct  aaatttcta  tactgataa  gcacttact  gtctaccaa  gaccgtttc  4200
gatgtactt  tagctactg  ccattctgt  ccattagga  gtgggccca  ttccatgac  4260
actgtttct  ccaacagag  tgattctgt  accacaacc  agttgcttc  tccttctaa  4320
gctacttct  agccgactc  tagtgccag  tctgatgcc  atttagtag  aggtggtga  4380
gatggtgat  actatgatg  tgatgatta  gatgacata  atagtgatc  ctttcccgt  4440
aataagtgt  tgtcatgtt  accctatag  gaatcacag  aaaaggtaa  gaatgactc  4500
gacacccaa  aaagcagtc  tgtggatca  agtgaccca  tttcacatt  gctctctga  4560
aataccgaa  aagaaaatg  aggcacggg  gtaactagg  tggataaaa  tcctgataa  4620
tcaccacca  caagtatgc  accccagaa  cacaatgat  gaagagagg  ccgtgacat  4680
cagatgggt  gtgctgtcc  tcctcacac  ccaggatct  aagcatggg  agttttgac  4740
agtgatgaa  agagtgggt  agggcaagg  acctcagat  gccttaatg  taatgagac  4800
tccacagat  tcagtttcc  agatgttaa  gaaaaggat  ctgatggtg  cctggaagc  4860
gatgacaca  gcatagctc  gggatctcc  cggtcctcc  caccatctg  tactagtgg  4920
cattcagga  tatccaaca  ttcagaggc  ggttagtta  gagcaaagg  atagaacga  4980
atgtgctga  tttcttgct  tgaaagtaa  aatagaaga  tcacggaag  aaagaattc  5040
ggtccacca  cagatcttc  ctttctaat  agaacgttc  atacattta  agctcttat  5100
aatatggtt  tactcatga  ttcgaatga  tatccaaca  attttggtt  ttgattttt  5160
ttatcttca  aatgcattg  gtgctgtta  taatcccta  tcctattgt  tgtagtatc  5220
actatgtat  cataatacg  cattagaat  ttacaacgc  gtgtgctgt  ttaagacag  5280
ttaaatgtt  atacttgta  tctgaaaca  gttgtacac  aactctatt  gatttaaaa  5340
ctcagtaat  tgctataag  acccatcca  caatggtgg  cacttcaca  gtgcacaac  5400
gcttggaga  cttctcaaa  gaactacag  gctaagatt  gatagctaa  gaaggtttt  5460
ataaacatc  tactgcttt  aaactatcc  tgagcttct  ttttgttgc  taaagaggg  5520
agtataaac  accaaaata  attctactt  gtgtttgtt  cagtattcc  acttactaa  5580
cgacatgaa  atgcagaag  tgcataggt  ttgtatgac  agatgtaaa  gaaaaagcc  5640
acagccttt  ctgtagaga  gcatttcat  gttaatata  tttatgcaa  tgggtttat  5700
agccagatg  ttcttggag  agactgcaa  ctagaatac  gatgtgtgc  ttaaatgtc  5760
atggtaaca  aattcgaaa  tccattaag  gtttaaaaa  aaaactagg  gattccatt  5820
aattcacgg  aagaatttt  taatttgct  tgattaagt  atgaggttt  tttttaatg  5880
acaaggaaa  tatttaaat  ttagcaagt  aaaagataa  ataatgtat  atgtgacat  5940
gggtaataa  tgcacagag  ttaatatta  aaatccaca  tatagagcc  atctcatta  6000
aatatatat  ctctttgtt  ttttcatca  tcacattag  tgtaaactc  ttagtatgg  6060
agcaattaa  agattatat  tttagataa  acagtttct  tcttttctg  attctgacg  6120
gatctccac  taacgttga  tttcagctt  aatatatga  ctgatgtgt  agaaggagt  6180
atgagtcca  gggtcactg  agtcaggaa  gttgttaca  atgtgaatt  ttatctgtc  6240
tcaattata  cacttgttt  tctttctat  tttttagat  tatctgaaa  ggaaagatc  6300
tgaacatac  ctaatggac  gaccatgca  atacatata  cccaaagca  tatatctag  6360
attatcgaa  aaagttatt  ctcttagat  tactaatta  atttattta  ctgttaaga  6420
taagttccc  cactaatga  aacacagca  tatggataa  acatccatc  tcaggaaat  6480
atacagtta  tgaagggag  aggatcaaa  agaattagg  aaaacaatt  ttacctgtt  6540
ttaaagctg  atctgtaaa  ctaattcaa  gtcagtctt  tccaattat  gaatattcc  6600
tagtctgaa  ctcatcatt  atggtactt  taaattgta  aaaaactga  atgatgttt  6660
ctaaactaa  ataaatagg  caaatatag  tgagagtga  caaagactg  aagatactt  6720
ctctggttc  cataaagag  ccatccaaa  ctaaccctg  gaatgtatt  ttagtgtct  6780
tctcttaga  catgcttac  t  6801



<210> 7969
<211> 2316
<212> PRT
<213> Rattus norvegicus
<308> Q62656
<400> 7969

Met Arg Ile Leu Gln Ser Phe Leu Ala Cys Val Gln Leu Leu Cys Val 
  1               5                  10                  15
Cys Arg Leu Asp Trp Ala Tyr Gly Tyr Tyr Arg Gln Gln Arg Lys Leu 
             20                  25                  30
Val Glu Glu Ile Gly Trp Ser Tyr Thr Gly Ala Leu Asn Gln Lys Asn 
         35                  40                  45
Trp Gly Lys Lys Tyr Pro Ile Cys Asn Ser Pro Lys Gln Ser Pro Ile 
     50                  55                  60
Asn Ile Asp Glu Asp Leu Thr Gln Val Asn Val Asn Leu Lys Lys Leu 
 65                  70                  75                  80
Lys Phe Gln Gly Trp Glu Lys Pro Ser Leu Glu Asn Thr Phe Ile His 
                 85                  90                  95
Asn Thr Gly Lys Thr Val Glu Ile Asn Leu Thr Asn Asp Tyr Tyr Leu 
             100                105                110
Ser Gly Gly Leu Ser Glu Lys Val Phe Lys Ala Ser Lys Met Thr Phe 
         115                120                125
His Trp Gly Lys Cys Asn Val Ser Ser Glu Gly Ser Glu His Ser Leu 
     130                135                140
Glu Gly Gln Lys Phe Pro Leu Glu Met Gln Ile Tyr Cys Phe Asp Ala 
 145                150                155                160
Asp Arg Phe Ser Ser Phe Glu Glu Thr Val Lys Gly Lys Gly Arg Leu 
                 165                170                175
Arg Ala Leu Ser Ile Leu Phe Glu Ile Gly Val Glu Glu Asn Leu Asp 
             180                185                190
Tyr Lys Ala Ile Ile Asp Gly Thr Glu Ser Val Ser Arg Phe Gly Lys 
         195                200                205
Gln Ala Ala Leu Asp Pro Phe Ile Leu Gln Asn Leu Leu Pro Asn Ser 
     210                215                220
Thr Asp Lys Tyr Tyr Ile Tyr Asn Gly Ser Leu Thr Ser Pro Pro Cys 
 225                230                235                240
Thr Asp Thr Val Glu Trp Ile Val Phe Lys Asp Thr Val Ser Ile Ser 
                 245                250                255
Glu Ser Gln Leu Ala Val Phe Cys Glu Val Leu Thr Met Gln Gln Ser 
             260                265                270
Gly Tyr Val Met Leu Met Asp Tyr Leu Gln Asn Asn Phe Arg Glu Gln 
         275                280                285
Gln Tyr Lys Phe Ser Arg Gln Val Phe Ser Ser Tyr Thr Gly Lys Glu 
     290                295                300
Glu Ile His Glu Ala Val Cys Ser Ser Glu Pro Glu Asn Val Gln Ala 
 305                310                315                320
Asp Pro Glu Asn Tyr Thr Ser Leu Leu Ile Thr Trp Glu Arg Pro Arg 
                 325                330                335
Val Val Tyr Asp Thr Met Ile Glu Lys Phe Ala Val Leu Tyr Gln Pro 
             340                345                350
Leu Glu Gly Asn Asp Gln Thr Lys His Glu Phe Leu Thr Asp Gly Tyr 
         355                360                365
Gln Asp Leu Gly Ala Ile Leu Asn Asn Leu Ile Pro Asn Met Ser Tyr 
     370                375                380
Val Leu Gln Ile Val Ala Ile Cys Ser Asn Gly Leu Tyr Gly Lys Tyr 
 385                390                395                400
Ser Asp Gln Leu Ile Val Asp Met Pro Thr Glu Asp Ala Glu Leu Asp 
                 405                410                415
Leu Phe Pro Glu Leu Ile Gly Thr Glu Glu Ile Ile Lys Glu Glu Asn 
             420                425                430
Tyr Gly Lys Gly Asn Glu Glu Asp Thr Gly Leu Asn Pro Gly Arg Asp 
         435                440                445
Ser Ala Thr Asn Gln Ile Arg Lys Lys Glu Pro Gln Val Ser Thr Thr 
     450                455                460
Thr His Tyr Asn His Met Gly Thr Lys Tyr Asn Glu Ala Lys Thr Asn 
 465                470                475                480
Arg Ser Pro Thr Arg Gly Ser Glu Phe Ser Gly Lys Ser Asp Val Leu 
                 485                490                495
Asn Thr Ser Leu Asn Pro Thr Ser Gln Gln Val Ala Glu Phe Asn Pro 
             500                505                510
Glu Arg Glu Met Ser Leu Pro Ser Gln Ile Gly Thr Asn Leu Pro Pro 
         515                520                525
His Ser Val Glu Gly Thr Ser Ala Ser Leu Asn Ser Gly Ser Lys Thr 
     530                535                540
Leu Leu Val Phe Pro Gln Met Asn Leu Ser Gly Thr Ala Glu Ser Leu 
 545                550                555                560
Asn Met Val Ser Ile Thr Glu Tyr Lys Glu Val Ser Ala Asp Leu Ser 
                 565                570                575
Glu Glu Glu Asn Leu Leu Thr Asp Phe Lys Leu Asp Ser Gly Ala Asp 
             580                585                590
Asp Ser Ser Gly Ser Ser Pro Ala Ser Ser Thr Val Pro Phe Ser Thr 
         595                600                605
Asp Asn Leu Ser His Gly Tyr Thr Ser Ser Ser Asp Thr Pro Glu Ala 
     610                615                620
Val Thr Tyr Asp Val Leu Arg Pro Glu Ser Thr Arg Asn Ala Leu Glu 
 625                630                635                640
Asp Ser Ala Pro Ser Gly Ser Glu Glu Ser Leu Lys Asp Pro Ser Leu 
                 645                650                655
Glu Gly Ser Val Trp Phe Pro Gly Ser Thr Asp Leu Thr Thr Gln Ser 
             660                665                670
Glu Thr Gly Ser Gly Arg Glu Gly Phe Leu Gln Val Asn Ser Thr Asp 
         675                680                685
Phe Gln Val Asp Glu Ser Arg Glu Thr Thr Glu Thr Phe Ser Pro Asp 
     690                695                700
Ala Thr Ala Ser Arg Gly Pro Ser Val Thr Asp Met Glu Met Pro His 
 705                710                715                720
Tyr Ser Thr Phe Ala Tyr Pro Pro Thr Glu Val Thr Ser His Ala Phe 
                 725                730                735
Thr Pro Ser Ser Arg Pro Leu Asp Leu Ala Pro Thr Ser Asn Ile Leu 
             740                745                750
His Ser Gln Thr Thr Gln Pro Val Tyr Asn Gly Glu Thr Pro Leu Gln 
         755                760                765
Pro Ser Tyr Ser Ser Glu Val Phe Pro Leu Val Thr Pro Leu Leu Leu 
     770                775                780
Asp Asn Gln Thr Leu Asn Thr Thr Pro Ala Ala Ser Ser Ser Asp Ser 
 785                790                795                800
Ala Leu His Ala Thr Pro Val Phe Pro Ser Val Gly Val Ser Phe Asp 
                 805                810                815
Ser Ile Leu Ser Ser Tyr Asp Asp Ala Pro Leu Leu Pro Phe Ser Ser 
             820                825                830
Ala Ser Phe Ser Ser Asp Leu Phe His His Leu His Thr Val Ser Gln 
         835                840                845
Thr Leu Pro Gln Val Thr Ser Ala Ala Glu Arg Asp Glu Leu Ser Leu 
     850                855                860
His Ala Ser Leu Leu Val Ala Gly Gly Asp Leu Leu Leu Glu Pro Ser 
 865                870                875                880
Leu Val Gln Tyr Ser Asp Val Met Ser His Gln Val Thr Ile His Ala 
                 885                890                895
Ala Ser Asp Thr Leu Glu Phe Gly Ser Glu Ser Ala Val Leu Tyr Lys 
             900                905                910
Thr Ser Met Val Ser Gln Ile Glu Ser Pro Ser Ser Asp Val Val Met 
         915                920                925
His Ala Tyr Ser Ser Gly Pro Glu Thr Ser Tyr Ala Ile Glu Gly Ser 
     930                935                940
His His Val Leu Thr Val Ser Ser Ser Ser Ala Ile Pro Val His Asp 
 945                950                955                960
Ser Val Gly Val Ala Asp Gln Gly Ser Leu Leu Ile Asn Pro Ser His 
                 965                970                975
Ile Ser Leu Pro Glu Ser Ser Phe Ile Thr Pro Thr Ala Ser Leu Leu 
             980                985                990
Gln Leu Pro Pro Ala Leu Ser Gly Asp Gly Glu Trp Ser Gly Ala Ser 
         995                1000                1005
Ser Asp Ser Glu Leu Leu Leu Pro Asp Thr Asp Gly Leu Arg Thr Leu 
     1010                1015                1020
Asn Met Ser Ser Pro Val Ser Val Ala Asp Phe Thr Tyr Thr Thr Ser 
 1025                1030                1035                1040
Val Ser Gly Asp Asp Ile Lys Pro Leu Ser Lys Gly Glu Met Met Tyr 
                 1045                1050                1055
Gly Asn Glu Thr Glu Leu Lys Met Ser Ser Phe Ser Asp Met Ala Tyr 
             1060                1065                1070
Pro Ser Lys Ser Thr Val Val Pro Lys Met Ser Asp Ile Val Asn Lys 
         1075                1080                1085
Trp Ser Glu Ser Leu Lys Glu Thr Ser Val Ser Val Ser Ser Ile Asn 
     1090                1095                1100
Ser Val Phe Thr Glu Ser Leu Val Tyr Pro Ile Thr Lys Val Phe Asp 
 1105                1110                1115                1120
Gln Glu Ile Ser Arg Val Pro Glu Ile Ile Phe Pro Val Lys Pro Thr 
                 1125                1130                1135
His Thr Ala Ser Gln Ala Ser Gly Asp Thr Trp Leu Lys Pro Gly Leu 
             1140                1145                1150
Ser Thr Asn Ser Glu Pro Ala Leu Ser Asp Thr Ala Ser Ser Glu Val 
         1155                1160                1165
Ser His Pro Ser Thr Gln Pro Leu Leu Tyr Glu Ala Ala Ser Pro Phe 
     1170                1175                1180
Asn Thr Glu Ala Leu Leu Gln Pro Ser Phe Pro Ala Ser Asp Val Asp 
 1185                1190                1195                1200
Thr Leu Leu Lys Thr Ala Leu Pro Ser Gly Pro Arg Asp Pro Val Leu 
                 1205                1210                1215
Thr Glu Thr Pro Met Val Glu Gln Ser Ser Ser Ser Val Ser Leu Pro 
             1220                1225                1230
Leu Ala Ser Glu Ser Ala Ser Ser Lys Ser Thr Leu His Phe Thr Ser 
         1235                1240                1245
Val Pro Val Leu Asn Met Ser Pro Ser Asp Val His Pro Thr Ser Leu 
     1250                1255                1260
Gln Arg Leu Thr Val Pro His Ser Arg Glu Glu Tyr Phe Glu Gln Gly 
 1265                1270                1275                1280
Leu Leu Lys Ser Lys Ser Pro Gln Gln Val Leu Pro Ser Leu His Ser 
                 1285                1290                1295
His Asp Glu Phe Phe Gln Thr Ala His Leu Asp Ile Ser Gln Ala Tyr 
             1300                1305                1310
Pro Pro Lys Gly Arg His Ala Phe Ala Thr Pro Ile Leu Ser Ile Asn 
         1315                1320                1325
Glu Pro Gln Asn Thr Leu Ile Asn Arg Leu Val Tyr Ser Glu Asp Ile 
     1330                1335                1340
Phe Met His Pro Glu Ile Ser Ile Thr Asp Lys Ala Leu Thr Gly Leu 
 1345                1350                1355                1360
Pro Thr Thr Val Ser Asp Val Leu Ile Ala Thr Asp His Ser Val Pro 
                 1365                1370                1375
Leu Gly Ser Gly Pro Ile Ser Met Thr Thr Val Ser Pro Asn Arg Asp 
             1380                1385                1390
Asp Ser Val Thr Thr Thr Lys Leu Leu Leu Pro Ser Lys Ala Thr Ser 
         1395                1400                1405
Lys Pro Thr His Ser Ala Arg Ser Asp Ala Asp Leu Val Gly Gly Gly 
     1410                1415                1420
Glu Asp Gly Asp Asp Tyr Asp Asp Asp Asp Tyr Asp Asp Ile Asp Ser 
 1425                1430                1435                1440
Asp Arg Phe Pro Val Asn Lys Cys Met Ser Cys Ser Pro Tyr Arg Glu 
                 1445                1450                1455
Ser Gln Glu Lys Val Met Asn Asp Ser Asp Thr Gln Glu Ser Ser Leu 
             1460                1465                1470
Val Asp Gln Ser Asp Pro Ile Ser His Leu Leu Ser Glu Asn Thr Glu 
         1475                1480                1485
Glu Glu Asn Gly Gly Thr Gly Val Thr Arg Val Asp Lys Ser Pro Asp 
     1490                1495                1500
Lys Ser Pro Pro Pro Ser Met Leu Pro Gln Lys His Asn Asp Gly Arg 
 1505                1510                1515                1520
Glu Asp Arg Asp Ile Gln Met Gly Ser Ala Val Leu Pro His Thr Pro 
                 1525                1530                1535
Gly Ser Lys Ala Trp Ala Val Leu Thr Ser Asp Glu Glu Ser Gly Ser 
             1540                1545                1550
Gly Gln Gly Thr Ser Asp Ser Leu Asn Asp Asn Glu Thr Ser Thr Asp 
         1555                1560                1565
Phe Ser Phe Pro Asp Val Asn Glu Lys Asp Ala Asp Gly Val Leu Glu 
     1570                1575                1580
Ala Asp Asp Thr Gly Ile Ala Pro Gly Ser Pro Arg Ser Ser Thr Pro 
 1585                1590                1595                1600
Ser Val Thr Ser Gly His Ser Gly Val Ser Asn Ser Ser Glu Ala Glu 
                 1605                1610                1615
Ala Ser Asn Ser Ser His Glu Ser Arg Ile Gly Leu Ala Glu Gly Leu 
             1620                1625                1630
Glu Ser Glu Lys Lys Ala Val Ile Pro Leu Val Ile Val Ser Ala Leu 
         1635                1640                1645
Thr Phe Ile Cys Leu Val Val Leu Val Gly Ile Leu Ile Tyr Trp Arg 
     1650                1655                1660
Lys Cys Phe Gln Thr Ala His Phe Tyr Leu Glu Asp Asn Thr Ser Pro 
 1665                1670                1675                1680
Arg Val Ile Ser Thr Pro Pro Thr Pro Ile Phe Pro Ile Ser Asp Asp 
                 1685                1690                1695
Ile Gly Ala Ile Pro Ile Lys His Phe Pro Lys His Val Ala Asp Leu 
             1700                1705                1710
His Ala Ser Asn Gly Phe Thr Glu Glu Phe Glu Thr Leu Lys Glu Phe 
         1715                1720                1725
Tyr Gln Glu Val Gln Ser Cys Thr Val Asp Leu Gly Ile Thr Ala Asp 
     1730                1735                1740
Ser Ser Asn His Pro Asp Asn Lys His Lys Asn Arg Tyr Val Asn Ile 
 1745                1750                1755                1760
Val Ala Tyr Asp His Ser Arg Val Lys Leu Thr Gln Leu Ala Glu Lys 
                 1765                1770                1775
Asp Gly Lys Leu Thr Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr 
             1780                1785                1790
Asn Arg Pro Lys Ala Tyr Ile Ala Ala Gln Gly Pro Leu Lys Ser Thr 
         1795                1800                1805
Ala Glu Asp Phe Trp Arg Met Ile Trp Glu His Asn Val Glu Val Ile 
     1810                1815                1820
Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys Cys Asp Gln 
 1825                1830                1835                1840
Tyr Trp Pro Thr Asp Gly Ser Glu Glu Tyr Gly Ser Phe Leu Val Asn 
                 1845                1850                1855
Gln Lys Asn Val Gln Val Leu Ala Tyr Tyr Thr Val Arg Asn Phe Thr 
             1860                1865                1870
Leu Arg Asn Thr Lys Ile Lys Lys Gly Ser Gln Lys Gly Arg Ser Ser 
         1875                1880                1885
Gly Arg Leu Val Thr Gln Tyr His Tyr Thr Gln Trp Pro Asp Met Gly 
     1890                1895                1900
Val Pro Glu Tyr Ser Leu Pro Val Leu Ala Phe Val Arg Lys Thr Ala 
 1905                1910                1915                1920
Gln Ala Lys Arg His Ala Val Gly Pro Val Val Val His Cys Ser Ala 
                 1925                1930                1935
Gly Val Gly Arg Thr Gly Thr Tyr Ile Val Leu Asp Ser Met Leu Gln 
             1940                1945                1950
Gln Ile Gln His Glu Gly Thr Val Asn Ile Phe Gly Phe Leu Lys His 
         1955                1960                1965
Ile Arg Ser Gln Arg Asn Tyr Leu Val Gln Thr Glu Glu Gln Tyr Val 
     1970                1975                1980
Phe Ile His Asp Thr Leu Val Glu Ala Ile Leu Ser Lys Glu Thr Glu 
 1985                1990                1995                2000
Val Pro Asp Ser His Ile His Ser Tyr Val Asn Thr Leu Leu Ile Pro 
                 2005                2010                2015
Gly Pro Ser Gly Lys Thr Lys Leu Glu Lys Gln Phe Gln Leu Leu Ser 
             2020                2025                2030
Gln Ser Asn Ile Leu Gln Ser Asp Tyr Ser Thr Ala Leu Lys Gln Cys 
         2035                2040                2045
Asn Arg Glu Lys Asn Arg Thr Ser Ser Ile Ile Pro Val Glu Arg Ser 
     2050                2055                2060
Arg Val Gly Ile Ser Ser Leu Ser Gly Glu Gly Thr Asp Tyr Ile Asn 
 2065                2070                2075                2080
Ala Ser Tyr Ile Met Gly Tyr Tyr Gln Ser Asn Glu Phe Ile Ile Thr 
                 2085                2090                2095
Gln His Pro Leu Leu His Thr Ile Lys Asp Phe Trp Arg Met Ile Trp 
             2100                2105                2110
Asp His Asn Ala Gln Leu Val Val Met Ile Pro Asp Gly Gln Asn Met 
         2115                2120                2125
Ala Glu Asp Glu Phe Val Tyr Trp Pro Asn Lys Asp Glu Pro Ile Asn 
     2130                2135                2140
Cys Glu Ser Phe Lys Val Thr Leu Met Ser Glu Glu His Lys Cys Leu 
 2145                2150                2155                2160
Ser Asn Glu Glu Lys Leu Ile Val Gln Asp Phe Ile Leu Glu Ala Thr 
                 2165                2170                2175
Gln Asp Asp Tyr Val Leu Glu Val Arg His Phe Gln Cys Pro Lys Trp 
             2180                2185                2190
Pro Asn Pro Asp Ser Pro Ile Ser Lys Thr Phe Glu Leu Ile Ser Ile 
         2195                2200                2205
Ile Lys Glu Glu Ala Ala Asn Arg Asp Gly Pro Met Ile Val His Asp 
     2210                2215                2220
Glu His Gly Gly Val Thr Ala Gly Thr Phe Cys Ala Leu Thr Thr Leu 
 2225                2230                2235                2240
Met His Gln Leu Glu Lys Glu Asn Ser Met Asp Val Tyr Gln Val Ala 
                 2245                2250                2255
Lys Met Ile Asn Leu Met Arg Pro Gly Val Phe Thr Asp Ile Glu Gln 
             2260                2265                2270
Tyr Gln Phe Leu Tyr Lys Val Val Leu Ser Leu Val Ser Thr Arg Gln 
         2275                2280                2285
Glu Glu Asn Pro Ser Thr Ser Leu Asp Ser Asn Gly Ala Ala Leu Pro 
     2290                2295                2300
Asp Gly Asn Ile Ala Glu Ser Leu Glu Ser Leu Val 
 2305                2310                2315



<210> 7970
<211> 7941
<212> DNA
<213> Homo sapiens
<308> M93426
<400> 7970

cacacatac  cacgcacga  ctcacttcg  tctatacac  ggaggatta  aacaaacaa  60
caaaaaaaa  atttccttc  ctccccctc  ctctccact  tgagaagca  aggagccgc  120
cggcgaggg  ccgcagacc  tctggaaat  cgaatccta  agcgtttcc  cgcttgcat  180
cagctcctc  gtgtttgcc  cctggattg  gctaatgga  actacagac  acagagaaa  240
cttgttgaa  agattggct  gtcctatac  ggagcactg  atcaaaaaa  ttggggaaa  300
aaatatcca  catgtaata  cccaaaaca  tctcctatc  atattgatg  agatcttac  360
caagtaaat  tgaatctta  gaaacttaa  tttcagggt  gggataaaa  atcattgga  420
aacacattc  ttcataaca  tgggaaaac  gtggaaatt  atctcacta  tgactaccg  480
gtcagcgga  gagtttcag  aatggtgtt  aaagcaagc  agataactt  tcactgggg  540
aaatgcaat  tgtcatctg  tggatcaga  catagttta  aaggacaaa  atttccact  600
gagatgcaa  tctactgct  tgatgcgga  cgattttca  gttttgagg  agcagtcaa  660
ggaaaaggg  agttaagag  tttatccat  ttgtttgag  ttgggacag  agaaaattt  720
gatttcaaa  cgattattg  tggagtcga  agtgttagt  gttttggga  gcaggctgc  780
ttagatcca  tcatactgt  gaaccttct  ccaaactca  ctgacaagt  ttacattta  840
aatggctca  tgacatctc  tccctgcac  gacacagtt  actggattg  ttttaaaga  900
acagttagc  tctctgaaa  ccagttggc  gttttttgt  aagttctta  aatgcaaca  960
tctggttat  tcatgctga  ggactactt  caaaacaat  ttcgagagc  acagtacaa  1020
ttctctaga  aggtgtttt  ctcatacac  ggaaaggaa  agattcatg  agcagtttg  1080
agttcagaa  cagaaaatg  tcaggctga  ccagagaat  ataccagcc  tcttgttac  1140
tgggaaaga  ctcgagtcg  ttatgatac  atgattgag  agtttgcag  tttgtacca  1200
cagttggat  gagaggacc  aaccaagca  gaatttttg  cagatggct  tcaagactt  1260
ggtgctatt  tcaataatt  gctacccaa  atgagttat  ttcttcaga  agtagccat  1320
tgcactaat  gcttatatg  aaaatacag  gaccaactg  ttgtcgaca  gcctactga  1380
aatcctgaa  ttgatcttt  ccctgaatt  attggaact  aagaaataa  caaggagga  1440
gaagaggga  aagacattg  agaaggcgc  attgtgaat  ctggtagag  cagtgctac  1500
aaccaaatc  ggaaaaagg  accccagat  tctaccaca  cacactaca  tcgcatagg  1560
acgaaatac  atgaagcca  gactaaccg  tccccaaca  gaggaagtg  attctctgg  1620
aagggtgat  ttcccaata  atctttaaa  tccacttcc  aaccagtca  taaattagc  1680
acagaaaaa  atatttcct  gacttctca  actgtgact  aactgccac  tcacactgt  1740
gaaggtact  cagcctctt  aaatgatgg  tctaaaact  ttcttagat  tccacatat  1800
aacttgtcg  ggactgcag  atccttaaa  acagtttct  taacagaat  tgaggagga  1860
agtttattg  ccagtttca  gcttgatac  ggagctgaa  attcttcag  ctccagtcc  1920
gcaacttct  ctatcccat  catctctga  aacatatcc  aagggtata  attttcctc  1980
gaaaaccca  agacaataa  atatgatgt  cttatacca  aatctgcta  aaatgcttc  2040
gaagattca  cttcatcag  ttcagaaga  tcactaaag  atccttcta  ggagggaaa  2100
gtgtggttt  ctagctcta  agacataac  gcacagccc  atgttggat  aggcagaga  2160
agctttctc  agactaatt  cactgagat  cgtgttgat  aatctgaga  gacaaccaa  2220
tccttttct  caggcccag  gatgtcaca  ggtccctca  ttacagatc  ggaaatgcc  2280
cattattct  cctttgcct  cttcccaac  gaggtaaca  ctcatgctt  taccccatc  2340
tccagacaa  aggatttgg  ctccacggt  aacgtggta  actcgcaga  aacccaacc  2400
gtatacaat  gtgagacac  tcttcaacc  tcctacagt  gtgaagtct  tcctctagt  2460
acccctttg  tgcttgaca  tcagatcct  aacactacc  ctgctgctt  aagtagtga  2520
tcggccttg  atgctacgc  tgtatttcc  agtgtcgat  tgtcatttg  atccatcct  2580
tcttcctat  atggtgcac  tttgcttcc  ttttcctct  cttccttca  tagtgaatt  2640
tttcgccat  tgcatacag  ttctcaaat  cttccacaa  ttacttcag  taccgagag  2700
gataaggtg  ccttgcatg  ttctctgcc  gtggctggg  gtgatttgc  attagagcc  2760
agccttgct  agtattctg  tgtgctgtc  actactcat  ctgcttcag  gacgctgga  2820
tttggtagt  aatctggtg  tctttataa  acgcttatg  tttctcaag  tgaaccacc  2880
agcagtgat  ccatgatgc  tgcacgttc  tcagggcct  aaccttctt  tgccttgtc  2940
gataatgag  gctcccaac  catcttcac  gtttcttac  gttctgcaa  acctgtgca  3000
gattctgtg  gtgtaactt  tcagggttc  ttatttagc  gccctagcc  tataccaat  3060
cctaagtct  cgttaataa  cccaactgc  tcattactg  agcctactc  tgccctctc  3120
ggtgatggg  aatggtctg  agcctcttc  gatagtgaa  ttcttttac  tgacacaga  3180
gggctgaca  cccttaaca  ttcttcacc  gtttctgta  ctgaattta  atatacaac  3240
tctgtgttt  gtgatgata  taaggcgct  tctaaaagt  aaataatat  tggaaatga  3300
actgaactg  aaattcctt  tttcaatga  atggtttac  cttctgaaa  cacagtcat  3360
cccaacatg  atgataatg  aaataagtt  aatgcgtct  tacaagaaa  ctctgtttc  3420
atttctagc  ccaagggca  gtttccagg  tcccttgct  ataccacca  taaggtttt  3480
gatcatgag  ttagtcaag  tccagaaaa  aacttttca  ttcaaccta  acatactgt  3540
tctcaagca  ctggtgaca  ttcgcttaa  cctgtgctt  gtgcaaact  agagccagc  3600
tcctctgac  ctgcttcta  tgaaatgtt  tctccttca  ctcagctct  attttatga  3660
acctcagct  cttttagta  tgaagtatt  ctacaacct  cctttcagg  ttctgatgt  3720
gacaccttg  ttaaaactg  tcttccagc  gtgcccagt  atccaatat  ggttgaaac  3780
cccaaagtt  ataaaatta  ttctacaat  ttgcatctc  ttgtatcaa  ttctgcttc  3840
agtgaaaac  tgctgcact  tacatctgt  ccagttttt  atgtgtcgc  tacttctca  3900
atgcactct  cttcacttc  aggtttgac  atttcctat  caagtgaga  atatgaacc  3960
gttttgtta  aaagtgaaa  ttcccacca  gtggtacct  ctttgtaca  taatgatga  4020
ttgttccaa  cggccaatt  ggagattaa  caggcccat  ccccaaaag  aaggcatgt  4080
tttgctaca  ctgttttat  aattgatga  ccattaaat  cactaataa  taagcttat  4140
cattccgat  aaattttaa  ctccaccaa  agttctgtt  ctggtaagg  atttgctgg  4200
attccaaca  ttgcttctg  tacatttgt  tctactgat  attctgttc  tataggaaa  4260
gggcatgtt  ccattacag  tgtttctcc  cacagagat  gttctgtaa  ctcaacaaa  4320
ttgctgttt  cttctaagg  aacttctga  ctgagtcat  gtgccaaat  tgatgccgg  4380
ttagtgggt  gtggtgaag  tggtgacac  gatgatgat  gtgatgatg  tgatgacag  4440
gatagtgat  gcttatcca  tcataagtg  atgtcatgc  catcctata  agaatcaca  4500
gaaaaggta  tgaatgatt  agacaccca  gaaaacagt  ttatggatc  gaataatcc  4560
atctcatac  cactatctg  gaattctga  gaagataat  gagtcacaa  tgtatcctc  4620
gacagtcaa  ctggtatgg  cagaagtcc  ggtaaatca  catcagcaa  tgggctatc  4680
caaaagcac  atgatggaa  agaggaaaa  gacattcag  ctggtagtg  tctgcttcc  4740
ctcagccct  aatctaaag  atgggcagt  ctgacaagt  atgaagaaa  tggatcagg  4800
caaggtacc  cagatagcc  taatgagaa  gagacttcc  cagatttca  ttttgcaga  4860
actaatgaa  aagatgctg  tgggatcct  gcagcaggt  actcagaaa  aactcctgg  4920
ttcccacag  ccccaacat  atctgttac  agcgagaac  cagaagtgt  ccacgtttc  4980
gaggcagag  ccagtaata  tagccatga  tctcgtatt  gtctagctg  ggggttgga  5040
tccgagaag  aggcagtta  accccttgt  atcgtgtca  ccctgactt  tatctgtct  5100
gtggttctt  tgggtattc  catctactg  aggaaatgc  tccagactg  acactttta  5160
ttagaggac  gtacatccc  tagagttat  tccacacct  caacaccta  ctttccaat  5220
tcagatgat  tcggagcaa  tccaataaa  cactttcca  agcatgttg  agatttaca  5280
gcaagtagt  ggtttactg  agaatttga  acactgaaa  agttttacc  ggaagtgca  5340
agctgtact  ttgacttag  tattacagc  gacagctcc  accacccag  caacaagca  5400
aagaatcga  acataaata  cgttgccta  gatcatagc  gggttaagc  agcacagct  5460
gctgaaaag  atggcaaac  gactgatta  atcaatgcc  attatgttg  tggctacaa  5520
agaccaaaa  cttatattg  tgcccaagg  ccactgaaa  ccacagctg  agatttctg  5580
agaatgata  gggaacata  tgtggaagt  attgtcatg  taacaaacc  cgtggagaa  5640
ggaaggaga  aatgtgatc  gtactggcc  gccgatggg  gtgaggagt  cgggaactt  5700
ctggtcact  agaagagtg  gcaagtgct  gcctattat  ctgtgagga  ttttactct  5760
agaaacaca  aaataaaaa  gggctccca  aaaggaaga  ccagtggac  tgtggtcac  5820
cagtatcac  acacgcagt  gcctgacat  ggagtacca  agtactccc  gccagtgct  5880
acctttgtg  gaaaggcag  ctatgccaa  cgccatgca  tggggcctg  tgtcgtcca  5940
tgcagtgct  gagttggaa  aacaggcac  tatattgtg  tagacagta  gttgcagca  6000
attcaacac  aaggaactg  caacatatt  ggcttctta  aacacatcc  ttcacaaag  6060
aattatttg  tacaaactg  ggagcaata  gtcttcatt  atgatacac  ggttgaggc  6120
atacttagt  aagaaactg  ggtgctgga  agtcatatt  atgcctatg  taatgcact  6180
ctcattcct  gaccagcag  caaaacaaa  ctagagaaa  aattccagc  cctgagcca  6240
tcaaatata  agcagagtg  ctattctgc  gccctaaag  aatgcaaca  ggaaaagaa  6300
cgaacttct  ctatcatcc  tgtggaaag  tcaagggtt  gcatttcat  cctgagtgg  6360
gaaggcaca  actacatca  tgcctccta  atcatgggc  attaccaga  caatgaatt  6420
atcattacc  agcaccctc  ccttcatac  atcaaggat  tctggagga  gatatggga  6480
cataatgcc  aactggtgg  tatgattcc  gatggccaa  acatggcag  agatgaatt  6540
gtttactgg  caaataaag  tgagcctat  aattgtgag  gctttaagg  cactcttat  6600
gctgaagaa  acaaatgtc  atctaatga  gaaaaactt  taattcagg  ctttatctt  6660
gaagctaca  aggatgatt  tgtacttga  gtgaggcac  ttcagtgtc  taaatggcc  6720
aatccagat  gccccatta  taaaacttt  gaacttata  gtgttataa  agaagaagc  6780
gccaatagg  atgggccta  gattgttca  gatgagcat  gaggagtga  ggcaggaac  6840
ttctgtgct  tgacaaccc  tatgcacca  ctagaaaaa  aaaattccg  ggatgttta  6900
caggtagcc  agatgatca  tctgatgag  ccaggagtc  ttgctgaca  tgagcagta  6960
cagtttctc  acaaagtga  cctcagcct  gtgagcaca  ggcaggaag  gaatccatc  7020
acctctctg  acagtaatg  tgcagcatt  cctgatgga  atatagctg  gagcttaga  7080
tctttagtt  aacacagaa  ggggtgggg  gactcacat  tgagcattg  tttcctctt  7140
ctaaaatta  gcaggaaaa  cagtctagt  ctgttatct  ttgatttcc  atcacctga  7200
agtaacttt  atgacatag  attctgccg  caaatttat  tcattaaca  tgtgtgcct  7260
tttgcaaga  ttgtaattt  cttattatg  ttgaactaa  atgattgaa  tttacagta  7320
ttctaagaa  ggaattgtg  tattttttt  tgtattgat  ttaacagaa  atttcaatt  7380
atagaggtt  ggaattcca  actacagaa  atgtttgtt  ttagtgtca  atttttagc  7440
gtatttgta  caattatca  gtttgctag  aatataact  ttaatacag  agcctgtaa  7500
taaaacact  ttccatatg  tattcaaca  tttacaact  cagtattca  ctaaagtag  7560
aataatctg  tacttattg  aaatactgc  ctagtgtct  catggacca  atttatatt  7620
ataattgta  atttttata  tttactact  agtcaagtt  tctagttct  tgtaattgt  7680
tagtttaat  acgtagttc  ttagctggt  ttactctac  agttttctg  cattgtatt  7740
tgttaccta  gtcattaac  ttgtttcag  atgtaattt  aacttttgt  gaaaataga  7800
ataccttca  tttgaaaga  gtttttatg  gaataacac  ttaccaaac  ttgttcaaa  7860
ggtttttat  caaggaatt  caaaaataa  tataaatat  gccattaaa  aaaaaaaaa  7920
aaaaaaaaa  aaaaaaaaa  a  7941



<210> 7971
<211> 2314
<212> PRT
<213> Homo sapiens
<308> P23471
<400> 7971

Met Arg Ile Leu Lys Arg Phe Leu Ala Cys Ile Gln Leu Leu Cys Val 
  1               5                  10                  15
Cys Arg Leu Asp Trp Ala Asn Gly Tyr Tyr Arg Gln Gln Arg Lys Leu 
             20                  25                  30
Val Glu Glu Ile Gly Trp Ser Tyr Thr Gly Ala Leu Asn Gln Lys Asn 
         35                  40                  45
Trp Gly Lys Lys Tyr Pro Thr Cys Asn Ser Pro Lys Gln Ser Pro Ile 
     50                  55                  60
Asn Ile Asp Glu Asp Leu Thr Gln Val Asn Val Asn Leu Lys Lys Leu 
 65                  70                  75                  80
Lys Phe Gln Gly Trp Asp Lys Thr Ser Leu Glu Asn Thr Phe Ile His 
                 85                  90                  95
Asn Thr Gly Lys Thr Val Glu Ile Asn Leu Thr Asn Asp Tyr Arg Val 
             100                105                110
Ser Gly Gly Val Ser Glu Met Val Phe Lys Ala Ser Lys Ile Thr Phe 
         115                120                125
His Trp Gly Lys Cys Asn Met Ser Ser Asp Gly Ser Glu His Ser Leu 
     130                135                140
Glu Gly Gln Lys Phe Pro Leu Glu Met Gln Ile Tyr Cys Phe Asp Ala 
 145                150                155                160
Asp Arg Phe Ser Ser Phe Glu Glu Ala Val Lys Gly Lys Gly Lys Leu 
                 165                170                175
Arg Ala Leu Ser Ile Leu Phe Glu Val Gly Thr Glu Glu Asn Leu Asp 
             180                185                190
Phe Lys Ala Ile Ile Asp Gly Val Glu Ser Val Ser Arg Phe Gly Lys 
         195                200                205
Gln Ala Ala Leu Asp Pro Phe Ile Leu Leu Asn Leu Leu Pro Asn Ser 
     210                215                220
Thr Asp Lys Tyr Tyr Ile Tyr Asn Gly Ser Leu Thr Ser Pro Pro Cys 
 225                230                235                240
Thr Asp Thr Val Asp Trp Ile Val Phe Lys Asp Thr Val Ser Ile Ser 
                 245                250                255
Glu Ser Gln Leu Ala Val Phe Cys Glu Val Leu Thr Met Gln Gln Ser 
             260                265                270
Gly Tyr Val Met Leu Met Asp Tyr Leu Gln Asn Asn Phe Arg Glu Gln 
         275                280                285
Gln Tyr Lys Phe Ser Arg Gln Val Phe Ser Ser Tyr Thr Gly Lys Glu 
     290                295                300
Glu Ile His Glu Ala Val Cys Ser Ser Glu Pro Glu Asn Val Gln Ala 
 305                310                315                320
Asp Pro Glu Asn Tyr Thr Ser Leu Leu Val Thr Trp Glu Arg Pro Arg 
                 325                330                335
Val Val Tyr Asp Thr Met Ile Glu Lys Phe Ala Val Leu Tyr Gln Gln 
             340                345                350
Leu Asp Gly Glu Asp Gln Thr Lys His Glu Phe Leu Thr Asp Gly Tyr 
         355                360                365
Gln Asp Leu Gly Ala Ile Leu Asn Asn Leu Leu Pro Asn Met Ser Tyr 
     370                375                380
Val Leu Gln Ile Val Ala Ile Cys Thr Asn Gly Leu Tyr Gly Lys Tyr 
 385                390                395                400
Ser Asp Gln Leu Ile Val Asp Met Pro Thr Asp Asn Pro Glu Leu Asp 
                 405                410                415
Leu Phe Pro Glu Leu Ile Gly Thr Glu Glu Ile Ile Lys Glu Glu Glu 
             420                425                430
Glu Gly Lys Asp Ile Glu Glu Gly Ala Ile Val Asn Pro Gly Arg Asp 
         435                440                445
Ser Ala Thr Asn Gln Ile Arg Lys Lys Glu Pro Gln Ile Ser Thr Thr 
     450                455                460
Thr His Tyr Asn Arg Ile Gly Thr Lys Tyr Asn Glu Ala Lys Thr Asn 
 465                470                475                480
Arg Ser Pro Thr Arg Gly Ser Glu Phe Ser Gly Lys Gly Asp Val Pro 
                 485                490                495
Asn Thr Ser Leu Asn Ser Thr Ser Gln Pro Val Thr Lys Leu Ala Thr 
             500                505                510
Glu Lys Asp Ile Ser Leu Thr Ser Gln Thr Val Thr Glu Leu Pro Pro 
         515                520                525
His Thr Val Glu Gly Thr Ser Ala Ser Leu Asn Asp Gly Ser Lys Thr 
     530                535                540
Val Leu Arg Ser Pro His Met Asn Leu Ser Gly Thr Ala Glu Ser Leu 
 545                550                555                560
Asn Thr Val Ser Ile Thr Glu Tyr Glu Glu Glu Ser Leu Leu Thr Ser 
                 565                570                575
Phe Lys Leu Asp Thr Gly Ala Glu Asp Ser Ser Gly Ser Ser Pro Ala 
             580                585                590
Thr Ser Ala Ile Pro Phe Ile Ser Glu Asn Ile Ser Gln Gly Tyr Ile 
         595                600                605
Phe Ser Ser Glu Asn Pro Glu Thr Ile Thr Tyr Asp Val Leu Ile Pro 
     610                615                620
Glu Ser Ala Arg Asn Ala Ser Glu Asp Ser Thr Ser Ser Gly Ser Glu 
 625                630                635                640
Glu Ser Leu Lys Asp Pro Ser Met Glu Gly Asn Val Trp Phe Pro Ser 
                 645                650                655
Ser Thr Asp Ile Thr Ala Gln Pro Asp Val Gly Ser Gly Arg Glu Ser 
             660                665                670
Phe Leu Gln Thr Asn Tyr Thr Glu Ile Arg Val Asp Glu Ser Glu Lys 
         675                680                685
Thr Thr Lys Ser Phe Ser Ala Gly Pro Val Met Ser Gln Gly Pro Ser 
     690                695                700
Val Thr Asp Leu Glu Met Pro His Tyr Ser Thr Phe Ala Tyr Phe Pro 
 705                710                715                720
Thr Glu Val Thr Pro His Ala Phe Thr Pro Ser Ser Arg Gln Gln Asp 
                 725                730                735
Leu Val Ser Thr Val Asn Val Val Tyr Ser Gln Thr Thr Gln Pro Val 
             740                745                750
Tyr Asn Gly Glu Thr Pro Leu Gln Pro Ser Tyr Ser Ser Glu Val Phe 
         755                760                765
Pro Leu Val Thr Pro Leu Leu Leu Asp Asn Gln Ile Leu Asn Thr Thr 
     770                775                780
Pro Ala Ala Ser Ser Ser Asp Ser Ala Leu His Ala Thr Pro Val Phe 
 785                790                795                800
Pro Ser Val Asp Val Ser Phe Glu Ser Ile Leu Ser Ser Tyr Asp Gly 
                 805                810                815
Ala Pro Leu Leu Pro Phe Ser Ser Ala Ser Phe Ser Ser Glu Leu Phe 
             820                825                830
Arg His Leu His Thr Val Ser Gln Ile Leu Pro Gln Val Thr Ser Ala 
         835                840                845
Thr Glu Ser Asp Lys Val Pro Leu His Ala Ser Leu Pro Val Ala Gly 
     850                855                860
Gly Asp Leu Leu Leu Glu Pro Ser Leu Ala Gln Tyr Ser Asp Val Leu 
 865                870                875                880
Ser Thr Thr His Ala Ala Ser Glu Thr Leu Glu Phe Gly Ser Glu Ser 
                 885                890                895
Gly Val Leu Tyr Lys Thr Leu Met Phe Ser Gln Val Glu Pro Pro Ser 
             900                905                910
Ser Asp Ala Met Met His Ala Arg Ser Ser Gly Pro Glu Pro Ser Tyr 
         915                920                925
Ala Leu Ser Asp Asn Glu Gly Ser Gln His Ile Phe Thr Val Ser Tyr 
     930                935                940
Ser Ser Ala Ile Pro Val His Asp Ser Val Gly Val Thr Tyr Gln Gly 
 945                950                955                960
Ser Leu Phe Ser Gly Pro Ser His Ile Pro Ile Pro Lys Ser Ser Leu 
                 965                970                975
Ile Thr Pro Thr Ala Ser Leu Leu Gln Pro Thr His Ala Leu Ser Gly 
             980                985                990
Asp Gly Glu Trp Ser Gly Ala Ser Ser Asp Ser Glu Phe Leu Leu Pro 
         995                1000                1005
Asp Thr Asp Gly Leu Thr Ala Leu Asn Ile Ser Ser Pro Val Ser Val 
     1010                1015                1020
Ala Glu Phe Thr Tyr Thr Thr Ser Val Phe Gly Asp Asp Asn Lys Ala 
 1025                1030                1035                1040
Leu Ser Lys Ser Glu Ile Ile Tyr Gly Asn Glu Thr Glu Leu Gln Ile 
                 1045                1050                1055
Pro Ser Phe Asn Glu Met Val Tyr Pro Ser Glu Ser Thr Val Met Pro 
             1060                1065                1070
Asn Met Tyr Asp Asn Val Asn Lys Leu Asn Ala Ser Leu Gln Glu Thr 
         1075                1080                1085
Ser Val Ser Ile Ser Ser Thr Lys Gly Met Phe Pro Gly Ser Leu Ala 
     1090                1095                1100
His Thr Thr Thr Lys Val Phe Asp His Glu Ile Ser Gln Val Pro Glu 
 1105                1110                1115                1120
Asn Asn Phe Ser Val Gln Pro Thr His Thr Val Ser Gln Ala Ser Gly 
                 1125                1130                1135
Asp Thr Ser Leu Lys Pro Val Leu Ser Ala Asn Ser Glu Pro Ala Ser 
             1140                1145                1150
Ser Asp Pro Ala Ser Ser Glu Met Leu Ser Pro Ser Thr Gln Leu Leu 
         1155                1160                1165
Phe Tyr Glu Thr Ser Ala Ser Phe Ser Thr Glu Val Leu Leu Gln Pro 
     1170                1175                1180
Ser Phe Gln Ala Ser Asp Val Asp Thr Leu Leu Lys Thr Val Leu Pro 
 1185                1190                1195                1200
Ala Val Pro Ser Asp Pro Ile Leu Val Glu Thr Pro Lys Val Asp Lys 
                 1205                1210                1215
Ile Ser Ser Thr Met Leu His Leu Ile Val Ser Asn Ser Ala Ser Ser 
             1220                1225                1230
Glu Asn Met Leu His Ser Thr Ser Val Pro Val Phe Asp Val Ser Pro 
         1235                1240                1245
Thr Ser His Met His Ser Ala Ser Leu Gln Gly Leu Thr Ile Ser Tyr 
     1250                1255                1260
Ala Ser Glu Lys Tyr Glu Pro Val Leu Leu Lys Ser Glu Ser Ser His 
 1265                1270                1275                1280
Gln Val Val Pro Ser Leu Tyr Ser Asn Asp Glu Leu Phe Gln Thr Ala 
                 1285                1290                1295
Asn Leu Glu Ile Asn Gln Ala His Pro Pro Lys Gly Arg His Val Phe 
             1300                1305                1310
Ala Thr Pro Val Leu Ser Ile Asp Glu Pro Leu Asn Thr Leu Ile Asn 
         1315                1320                1325
Lys Leu Ile His Ser Asp Glu Ile Leu Thr Ser Thr Lys Ser Ser Val 
     1330                1335                1340
Thr Gly Lys Val Phe Ala Gly Ile Pro Thr Val Ala Ser Asp Thr Phe 
 1345                1350                1355                1360
Val Ser Thr Asp His Ser Val Pro Ile Gly Asn Gly His Val Ala Ile 
                 1365                1370                1375
Thr Ala Val Ser Pro His Arg Asp Gly Ser Val Thr Ser Thr Lys Leu 
             1380                1385                1390
Leu Phe Pro Ser Lys Ala Thr Ser Glu Leu Ser His Ser Ala Lys Ser 
         1395                1400                1405
Asp Ala Gly Leu Val Gly Gly Gly Glu Asp Gly Asp Thr Asp Asp Asp 
     1410                1415                1420
Gly Asp Asp Asp Asp Asp Arg Asp Ser Asp Gly Leu Ser Ile His Lys 
 1425                1430                1435                1440
Cys Met Ser Cys Ser Ser Tyr Arg Glu Ser Gln Glu Lys Val Met Asn 
                 1445                1450                1455
Asp Ser Asp Thr His Glu Asn Ser Leu Met Asp Gln Asn Asn Pro Ile 
             1460                1465                1470
Ser Tyr Ser Leu Ser Glu Asn Ser Glu Glu Asp Asn Arg Val Thr Ser 
         1475                1480                1485
Val Ser Ser Asp Ser Gln Thr Gly Met Asp Arg Ser Pro Gly Lys Ser 
     1490                1495                1500
Pro Ser Ala Asn Gly Leu Ser Gln Lys His Asn Asp Gly Lys Glu Glu 
 1505                1510                1515                1520
Asn Asp Ile Gln Thr Gly Ser Ala Leu Leu Pro Leu Ser Pro Glu Ser 
                 1525                1530                1535
Lys Ala Trp Ala Val Leu Thr Ser Asp Glu Glu Ser Gly Ser Gly Gln 
             1540                1545                1550
Gly Thr Ser Asp Ser Leu Asn Glu Asn Glu Thr Ser Thr Asp Phe Ser 
         1555                1560                1565
Phe Ala Asp Thr Asn Glu Lys Asp Ala Asp Gly Ile Leu Ala Ala Gly 
     1570                1575                1580
Asp Ser Glu Ile Thr Pro Gly Phe Pro Gln Ser Pro Thr Ser Ser Val 
 1585                1590                1595                1600
Thr Ser Glu Asn Ser Glu Val Phe His Val Ser Glu Ala Glu Ala Ser 
                 1605                1610                1615
Asn Ser Ser His Glu Ser Arg Ile Gly Leu Ala Glu Gly Leu Glu Ser 
             1620                1625                1630
Glu Lys Lys Ala Val Ile Pro Leu Val Ile Val Ser Ala Leu Thr Phe 
         1635                1640                1645
Ile Cys Leu Val Val Leu Val Gly Ile Leu Ile Tyr Trp Arg Lys Cys 
     1650                1655                1660
Phe Gln Thr Ala His Phe Tyr Leu Glu Asp Ser Thr Ser Pro Arg Val 
 1665                1670                1675                1680
Ile Ser Thr Pro Pro Thr Pro Ile Phe Pro Ile Ser Asp Asp Val Gly 
                 1685                1690                1695
Ala Ile Pro Ile Lys His Phe Pro Lys His Val Ala Asp Leu His Ala 
             1700                1705                1710
Ser Ser Gly Phe Thr Glu Glu Phe Glu Thr Leu Lys Glu Phe Tyr Gln 
         1715                1720                1725
Glu Val Gln Ser Cys Thr Val Asp Leu Gly Ile Thr Ala Asp Ser Ser 
     1730                1735                1740
Asn His Pro Asp Asn Lys His Lys Asn Arg Tyr Ile Asn Ile Val Ala 
 1745                1750                1755                1760
Tyr Asp His Ser Arg Val Lys Leu Ala Gln Leu Ala Glu Lys Asp Gly 
                 1765                1770                1775
Lys Leu Thr Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr Asn Arg 
             1780                1785                1790
Pro Lys Ala Tyr Ile Ala Ala Gln Gly Pro Leu Lys Ser Thr Ala Glu 
         1795                1800                1805
Asp Phe Trp Arg Met Ile Trp Glu His Asn Val Glu Val Ile Val Met 
     1810                1815                1820
Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys Cys Asp Gln Tyr Trp 
 1825                1830                1835                1840
Pro Ala Asp Gly Ser Glu Glu Tyr Gly Asn Phe Leu Val Thr Gln Lys 
                 1845                1850                1855
Ser Val Gln Val Leu Ala Tyr Tyr Thr Val Arg Asn Phe Thr Leu Arg 
             1860                1865                1870
Asn Thr Lys Ile Lys Lys Gly Ser Gln Lys Gly Arg Pro Ser Gly Arg 
         1875                1880                1885
Val Val Thr Gln Tyr His Tyr Thr Gln Trp Pro Asp Met Gly Val Pro 
     1890                1895                1900
Glu Tyr Ser Leu Pro Val Leu Thr Phe Val Arg Lys Ala Ala Tyr Ala 
 1905                1910                1915                1920
Lys Arg His Ala Val Gly Pro Val Val Val His Cys Ser Ala Gly Val 
                 1925                1930                1935
Gly Arg Thr Gly Thr Tyr Ile Val Leu Asp Ser Met Leu Gln Gln Ile 
             1940                1945                1950
Gln His Glu Gly Thr Val Asn Ile Phe Gly Phe Leu Lys His Ile Arg 
         1955                1960                1965
Ser Gln Arg Asn Tyr Leu Val Gln Thr Glu Glu Gln Tyr Val Phe Ile 
     1970                1975                1980
His Asp Thr Leu Val Glu Ala Ile Leu Ser Lys Glu Thr Glu Val Leu 
 1985                1990                1995                2000
Asp Ser His Ile His Ala Tyr Val Asn Ala Leu Leu Ile Pro Gly Pro 
                 2005                2010                2015
Ala Gly Lys Thr Lys Leu Glu Lys Gln Phe Gln Leu Leu Ser Gln Ser 
             2020                2025                2030
Asn Ile Gln Gln Ser Asp Tyr Ser Ala Ala Leu Lys Gln Cys Asn Arg 
         2035                2040                2045
Glu Lys Asn Arg Thr Ser Ser Ile Ile Pro Val Glu Arg Ser Arg Val 
     2050                2055                2060
Gly Ile Ser Ser Leu Ser Gly Glu Gly Thr Asp Tyr Ile Asn Ala Ser 
 2065                2070                2075                2080
Tyr Ile Met Gly Tyr Tyr Gln Ser Asn Glu Phe Ile Ile Thr Gln His 
                 2085                2090                2095
Pro Leu Leu His Thr Ile Lys Asp Phe Trp Arg Met Ile Trp Asp His 
             2100                2105                2110
Asn Ala Gln Leu Val Val Met Ile Pro Asp Gly Gln Asn Met Ala Glu 
         2115                2120                2125
Asp Glu Phe Val Tyr Trp Pro Asn Lys Asp Glu Pro Ile Asn Cys Glu 
     2130                2135                2140
Ser Phe Lys Val Thr Leu Met Ala Glu Glu His Lys Cys Leu Ser Asn 
 2145                2150                2155                2160
Glu Glu Lys Leu Ile Ile Gln Asp Phe Ile Leu Glu Ala Thr Gln Asp 
                 2165                2170                2175
Asp Tyr Val Leu Glu Val Arg His Phe Gln Cys Pro Lys Trp Pro Asn 
             2180                2185                2190
Pro Asp Ser Pro Ile Ser Lys Thr Phe Glu Leu Ile Ser Val Ile Lys 
         2195                2200                2205
Glu Glu Ala Ala Asn Arg Asp Gly Pro Met Ile Val His Asp Glu His 
     2210                2215                2220
Gly Gly Val Thr Ala Gly Thr Phe Cys Ala Leu Thr Thr Leu Met His 
 2225                2230                2235                2240
Gln Leu Glu Lys Glu Asn Ser Val Asp Val Tyr Gln Val Ala Lys Met 
                 2245                2250                2255
Ile Asn Leu Met Arg Pro Gly Val Phe Ala Asp Ile Glu Gln Tyr Gln 
             2260                2265                2270
Phe Leu Tyr Lys Val Ile Leu Ser Leu Val Ser Thr Arg Gln Glu Glu 
         2275                2280                2285
Asn Pro Ser Thr Ser Leu Asp Ser Asn Gly Ala Ala Leu Pro Asp Gly 
     2290                2295                2300
Asn Ile Ala Glu Ser Leu Glu Ser Leu Val 
 2305                2310



<210> 7972
<211> 14984
<212> DNA
<213> Rattus norvegicus
<308> U05013
<400> 7972

aagcttgtg  tttaactat  gccacatcc  tgtgatgcc  cttgtctgg  gtagccagt  60
ggcttctct  ttgttgacc  atctgttag  ttttgtcaa  tgcttgata  tgttgaggc  120
catctctca  taccccgtc  gtggagctc  tcctcagta  cccatgtct  gcctcttgt  180
tgttgtgat  gcacacatg  tggactgct  tcgagaagg  gtctgggca  atctgctgt  240
agagctgct  aactcattt  ccagagact  cagatggag  agactcgct  caggccgta  300
atagtgtag  gtgatacaa  cgctgaaat  tgtacctaa  tcaatagtc  agactactc  360
tgtaaatgg  agatggctg  ggggttgga  agactatat  tgggaatct  ccacttagg  420
aaataacac  aaatttctg  tgtagatca  gtaaatgca  ggcagcagc  gtttcttct  480
cctctcaat  cttggaagt  acatcgagg  gcctagtgc  aagttctgc  aagtaatca  540
tgtcactat  gggtttgtt  ttttttaat  tttaaatat  attacgagg  atattgcaa  600
tactttatg  taacagtgg  tgattatga  tttatctta  aaatttgac  atacataga  660
catttgata  gatggttgt  ttatataca  aaggttctg  tttcagtcc  cagcaaaaa  720
aaaaaaagg  tgattgtat  aaagtacat  cctgtatat  ggtctgcat  gagtgttgc  780
ttgagtgtt  ttaaaccca  tcagtcacc  acccaccca  atcacacac  cagctccat  840
cacacaggg  ttctctgtg  agttctggc  gtcctggga  ttactcgga  tccaggttg  900
cctcaaact  agagatcca  ctgcttctg  ttcccaagt  ctgggatta  aggctctca  960
caccactgt  ccgaatctt  tttttaatt  tgtgtgtat  catctgagt  ttggtgtgg  1020
gcctgcaga  gccaggaga  ggcgtcaga  tcccaggag  tagagttat  ggtggctgt  1080
aatactgaa  agagtgaat  agtttctca  caagaacag  ctgtgctct  aattgctga  1140
ccatctctc  agctccaga  ctttttgtc  tagaagaaa  ttgatgagt  tgtacttgg  1200
tgtcttcct  tgggacata  ttgtctgta  gtaaatcaa  ccttatttg  tgagaacac  1260
gttgaagac  cccactcct  gagattcct  gtgccttgc  cattaaggt  gaaaagtat  1320
agatgaagt  agtctgaca  cccctcaag  ataggctgt  ctaagaaat  cagccgttt  1380
attctcatc  gtcagctgt  ctttattct  aactgccat  gctaccaag  tgtgtaaac  1440
taaaacagc  attggaagt  cttgatctt  tcaggaatg  cactgttag  aagtctcga  1500
taatcccat  ctctgaagg  ccctaggaa  tcatgtacg  nccttgcaa  aactagatg  1560
atgtagaag  taccagttg  taaagtctt  ttctgtgaa  gttgctgat  ttacagaac  1620
tttctctca  ccctcttac  ctaccattt  caaacatac  ttttcttaa  aaaatttaa  1680
attaggttt  ttcattttt  ttttagttt  atgtgtata  atatgtatg  gtaccattt  1740
cattcctgg  gcccacagg  gttcagaat  gggcattgg  ttcccctgg  ctggagtta  1800
agatggtgt  aactaccat  tgtgcactg  gaaatgaac  caggccctc  gtaagagag  1860
aagtgctct  agccccatc  gtatatata  attttcaga  gcaggtagg  ctgcttaga  1920
ttttaagta  tcactacac  gttgacaca  agatggttc  ctccctccc  ctctctcac  1980
tagctctgc  tgcctgttt  ccaactact  ggattaaaa  ccttcaacc  ccacctccc  2040
gatacacac  gagatccct  gagctcacc  agagttctc  ttctcagaa  caccactcc  2100
gagtgattc  tgtaactag  tctttgttt  tctcaatca  tatggcaac  agtgctata  2160
agatgtgga  accctattg  gacctcttt  gtgttggtt  gctctgatt  tattatcca  2220
taaggcctg  taagtctgg  tatttctct  caggcacgg  gtgttgggg  gtgccatct  2280
ccctttggg  ccaccttgg  ttgccctct  agcaaagtt  gccttacca  ggagcagtc  2340
tcttggatt  tataatttg  atgagccaa  gtaggtgtt  gagagacag  aagtaacaa  2400
tctgtgtgt  tgtgtgtgt  tgtgtgtgt  cgcgcggcg  gcatgtgca  gcccaagtg  2460
ctgcaagca  atgagacca  aghacactg  gtgccttct  agtcttggg  cacacttag  2520
tgttgaaac  ggtttctca  taaatttgt  gctcattga  gtggttagc  ggctggtta  2580
tgagctcca  ggatctgcc  ttctcctca  cctcagaac  gaagccata  atatgccac  2640
gtttctatg  gggtcatga  atctgaatg  aggtccttg  tgtttttac  caccaagct  2700
tgtcctcag  ccccagcaa  gcatttata  ctcagaaat  atagggtca  gcttttcat  2760
ctgaaacaa  ctatagttt  ttaccttcc  gtaggaata  atagtgtag  ctggcagtg  2820
acctcagtt  ctgtgtagc  tggagtgtg  ggtaacact  actcacacg  gtgaaccag  2880
gaaaactgt  ggggacaca  gaagaacct  ttaccttct  aatgactcg  gtttagttc  2940
aacttgact  ttaggtgtt  catgtagcc  aagctggcc  cttatttac  ttgtagcca  3000
gaatgacct  gaagttttg  tcttccggc  tctccctcc  ccctcagag  gctaggatt  3060
tgtaccaga  tgtaccagc  tgctccata  gcagtgctg  ggatttaac  caggacttt  3120
tcttatgct  ggcaaacac  gtacagctg  gccacagcc  aaccgaatc  aattttagt  3180
catcttccc  ctcttaagt  gactaagga  caacgccag  cctctgcgc  tgttcatta  3240
cgtcttctc  tagattatt  tgtgtcatt  tatagatct  tcatgctat  ccttgtggt  3300
ctctcgtcg  tttccccta  agaagaata  cttctcaac  cgtttttag  gttactgga  3360
aggaaagta  ctgggagct  ggttgcatt  gagcatcta  tcgctgact  tttccctcc  3420
actagaaat  gtgattctt  tagggacca  tatcagctc  ggacacccc  agaccaggt  3480
ctcagcaca  agatgtatt  gccctagag  tctaggaat  agagacaaa  ataggagag  3540
ggatgagga  aagagagag  gggaaggga  atttgtcat  ggggacaaa  gacagcctc  3600
ggatagaga  gacacagat  tagctcata  gcaaatcgt  ttaggatga  gtgtttaat  3660
ttaactgag  atgttaatt  agtgagcca  agaggtttt  attgattac  gacttcaat  3720
ctttgatag  tggaagttg  tattcagct  aggaagaga  gtggcctaa  gagggaatg  3780
tgatatcac  cacacacac  cacacacac  cacacacac  cacacacac  cacacacac  3840
cacacgtac  ttaacatac  tgtagggag  aggaggagt  tgctgttga  ttcatttat  3900
gtaggaatg  ctacactcc  tccctccct  ccccctggt  tgtgatgat  agtaagctt  3960
ttgtttaac  gggggtggt  acatagggc  agatggtgc  agttctata  aggagtaaa  4020
tcttgaact  tagacagcc  tctaggaag  aggcaggga  tcacaatgt  gataagtct  4080
atactgagc  gaaatctat  cagagggaa  tatgatcaa  tcttggtga  gaatgctta  4140
aacagccac  tagcctccc  tcccatatg  gaataacgg  gacttgtac  gtggacata  4200
actcattgt  gctgggtgc  actacttaa  gagtcaggc  tacaacgtt  gtctcattc  4260
agggagcag  taactctga  agtcctttt  cgtgtctcg  acctgctcc  ttccttcag  4320
tagaatgat  caagaagtc  ttattattc  tagatcatc  gattgagaa  tgaaccatg  4380
tatagtcct  agttacatt  cgctagcag  agtgctctg  attacccgg  cttgtgaaa  4440
ttttggagc  agtctccac  aaggagagt  tctttgaat  acatgttat  tcagaaagt  4500
atggtgcct  tgaggtgga  gttctatct  ctaggtggg  ctctaggaa  ctcttctgg  4560
agcttctgt  aatggaact  gctgcttca  tcattcagg  gttagcatg  gacagcagc  4620
gattggaaa  acagctggc  gtctgagga  gtgagtgga  tagcagtca  tgttttaaa  4680
ggggagggg  acagaagtg  ctttctgga  cttgtgata  cagaagggt  aaggactga  4740
ttccttgtt  ttagttgag  acatatctt  tttcttttt  ttttttttt  ttttttttt  4800
tggttcttt  tttcggtgc  ggggaccga  cccaggacc  tgcgcttcc  aggcaagag  4860
tctaccact  agctaaatc  ccaacccct  gttgaggac  tatcttaac  agttttttg  4920
ttacaccat  ctaattcaa  tcctatctg  gtttcctct  taccctttc  ttcctgatt  4980
gtgtcctac  cttttttct  cctatagaa  cacgctaca  aaaagagac  accagttgg  5040
taagctgtc  aacagaagc  gactgaaga  ctttcccgt  tcctgtcgt  gtgacgtgg  5100
tacatgctg  tgcagtcca  gctggcgac  aggtgcacc  ccacaccgc  ccccgggcc  5160
gcagttttc  gttagagag  tgtggtcag  gtttggctt  tcgtgtgtg  gtgtgtgtg  5220
gtgtgtgtg  gtgcgcaca  ccacagctt  ggtagcttg  catagctgt  ctagccctc  5280
actagttta  tgtcctttg  ggagcttag  gtccttggc  gtttgactg  atttatctt  5340
tagtgtgac  gtatataat  ttgtacaga  tgctatgac  ttttaaagg  gtatatgct  5400
gagtaaaca  atcagcgag  ggtcccgga  atgtagctt  tcagaggtt  aagataatt  5460
tttctactg  ggcaaggta  cctcttagt  ttaccctat  tggttactc  cttgaggaa  5520
ggacacata  tgtttccct  agcagtaga  tatgttggt  gaaagtgat  ctgagcctt  5580
ccagctaag  gagctttca  accctttaa  gactcagta  tcttcgaag  gaaataaat  5640
agtaaattg  acttgtagt  tagaaaact  aaaatgaca  acagcaggt  attagtatt  5700
ttttattgt  ttaaaatac  tattgtaaa  tagatgcgg  gatacgtgc  tgtgatcct  5760
gtaagctga  gtgaggctg  aggattgag  ttgaaagtc  tctgggtta  ctttaaagg  5820
cgggcaggg  ttggggatt  agctcagtg  tagagcgtt  cctagcaag  acaaggccc  5880
gggttcggt  cccagctct  aaaaaaaga  aaggggggg  aaaaaaagg  cgggcaaat  5940
gatctctgt  agttcaagg  catacatgg  tccaggatg  cagaggtac  gtgtaagac  6000
ctctctctg  gagagagag  gagagagag  gagagagag  gagagagag  gagagagag  6060
gggggaggg  gaggaagga  ggaaggaag  aaatagcat  gcctagagc  agcatggct  6120
gaccctact  tatagctca  gctattttc  atctcaagg  atgatacat  ctggttgat  6180
tatttaact  cttccctcc  tccctaccc  tttataggc  ttgaacttt  tttagccag  6240
gataacctt  aactcctgt  tttactccc  aagtactag  attacaggc  tgcgcagta  6300
rcaccttgc  ccctccccc  ctctcttct  tccttcttc  cttcctacc  acctaccta  6360
ctacctacc  acctaccta  ctacctacc  agtttagag  gtgttttgt  taacatcag  6420
aaggatttc  agaaagccc  gtgttccct  tcctggagc  aaatagttg  aaagacagt  6480
gtagccatt  tactggctg  gaagactga  gtaggggct  gcagatggt  aaattgaaa  6540
ggatgtatg  gaggatggc  cggggtggg  gctgacaca  acaaattaa  tgactcaga  6600
tgtgaaact  gtgattggg  accatgaaa  ccaactctt  cttttcttt  gtatttttt  6660
taaccataa  cagctttat  aaagatgct  ttcataaac  atcatggta  ttcaggcaa  6720
acatgggca  acagtcaac  atatacagg  acttccaaa  tcccttctt  tatagacta  6780
caaaatcag  aatccacta  aaaacccaa  gaagtcttc  ttcagtgct  tgaaagggg  6840
agtagctta  agtgagggt  gacatttca  gttaaggag  ttgtttaac  actttccac  6900
agccgaccc  gactgtcag  actgaacat  gcagaatct  aagatccac  gtcttttac  6960
aaaggaacc  gtgctcttc  gagaacact  aaagtcact  caaagtcca  gtgcccaat  7020
gactagaaa  ccaattttg  gggtgaggc  ccaacgggt  tctggtttt  agggaatta  7080
gtctgtgtt  atggtacgg  gggagggaa  aggatatag  aatgaattt  gagtttcca  7140
agaccacag  ccttggtgg  tacccacgc  agaccaggt  gtccttttg  aattatcag  7200
gaaaggggt  ttctgtcct  aattcagct  gggtgatat  ttgttggtg  cacatgatc  7260
ttcccccca  ccccaacaa  gaagtgttc  tgtgctaac  atatagtta  aaaaaaaaa  7320
gtaaaacaa  attctgcat  tttataaaa  ttgataaaa  atagtattt  aaactgtgc  7380
gtcaccaga  gtacagagt  ttcaaaaat  cacacacgt  tcttggcct  tccagcacc  7440
tcagctttc  gtgcctggt  tgtgttggc  tctccgttg  ccgcatggt  accggcatt  7500
gctctcccc  tctctccct  ctctgcagg  ccgttttag  cctgggcta  ggctttgga  7560
gagcaggtt  ggcagaccc  ccttgcaga  ccctggggc  cctccttca  cttggcttt  7620
tctccttta  cgtcccctt  agcctttct  ttgggcatg  cagtggcag  ggatgtcgg  7680
gctgagcac  ggtttacag  ggccgacgg  tttggtcca  tccggggtc  tcctcgctg  7740
ttcttcaca  tgctcttct  ttgtatttt  aaaagatga  aagggcctt  ttgttcaag  7800
aaattgcac  cccagaatg  gcacttagt  ccagataaa  cagcgacta  attttagtc  7860
ctgctgttc  ctgtaataa  tggggtaca  gtatcattc  cagaactat  gaagtgata  7920
attacatta  tattacttt  ctcttttat  tacctcact  catggtaac  tttgtgact  7980
tgcttgtcc  tgccattgt  atgctgtac  ttgaaaagc  ggggatctg  aattctaag  8040
tgtcacagt  cagcttaga  gctctggga  actttaccg  attgtactc  tctcttctg  8100
gtaaccggg  ctctcatgt  gtactcttt  ccttgttgc  atctgtcac  gagagacca  8160
aaacatttc  tgtctatta  ggtcccaga  gtgtgggat  gcctccttc  actttcact  8220
ctcctcccc  accccacct  ctttcctgc  ctttctttg  gcatttggt  ttttgtttg  8280
ttgttttca  ggtcttaat  agaggccaa  cctactctg  cttggtacc  gcctacatc  8340
aaaaaaaaa  aaaaaacct  agaacttga  ctgcagctg  acccaagct  ctctcaaat  8400
ccagggagg  cctcatggc  tgtcattag  ccatacccc  gagttactc  ctagcaaca  8460
ttaatcaaa  atcagtctg  ttgtttctt  gtgagacca  ttgtgattg  tcagtctta  8520
ttcaggaca  ctacctgta  gtgcttgcc  ggctgaaca  cccctatgt  agggttggg  8580
tgaaggaga  cccaagccc  agctttaat  aagagacct  aatgtgatt  cattggaaa  8640
ggccccttg  tgtctttgg  attcacgaa  acttctggg  ataacatta  taggtacgc  8700
aatgggctg  aactcgtta  agacttagc  ttatagatc  ggccttgaa  ttgcagtga  8760
cctcttgct  ctgtaaatc  acattaatt  tttgcaaac  cttagaagg  ccatgtagg  8820
gtcatccta  acctgacaa  gcttgcctc  gccattcct  agaaacacg  cacggcagc  8880
ttgcactac  ttactgctg  accacatcc  aactctgag  ccttgcgtt  ttgacggtt  8940
ttctagaag  ctcctccat  tttgatggc  atctgcctt  acattctga  gggcagttg  9000
gtcccatag  tctgaagta  gtatgcttt  gagtcaagc  aatgttgtt  gtactatgt  9060
agtttcatt  aacctcaat  ggaatgcaa  tagaagacc  agcttgttg  cacatgtct  9120
taaccagta  tcaggaggc  gaggcatta  gattagcac  agtttagtt  gggctatag  9180
tctacttca  aaaaggctt  ggaagtgca  gatgtgtgt  aaaaaaaaa  ttgaagggg  9240
tggagagat  gctcagtag  agaatactt  gtgctctta  atcttataa  gaactaggg  9300
tcagttctc  acacccaca  aggtctcac  actctagtt  caaggcatt  tctacacca  9360
cttttgact  ttctggaca  caggcatgc  catgacaca  aaatgcatg  aggtaaaat  9420
ggtatatat  aggttaaaa  aaatccgct  aaatttttt  taaaaactg  ggactgtgc  9480
gagcaaacc  cacacatag  ctaaaaacg  aaagatggc  gctgggtcc  tagagcatg  9540
actaatgtg  ttctgtagg  gagatatgt  ttatggtat  ttttgtttt  gttttctcc  9600
tttccaaga  cttgctttt  ctttttttc  tttcctttt  ttccttttt  tgggggggt  9660
ggggtgggg  caaggtttc  ctgtgtact  tttactgtc  tggaacttg  tctgtagac  9720
aggctgcct  aaactcaga  gtctatctg  ttctgcctc  caaggactg  ttaaaagag  9780
tgccatcac  gcctggctc  aaggagttt  cacagtgct  gacatttga  caaaggtct  9840
acacatgtt  gccaagcac  ttagcctga  ctacataca  tcactttat  ggcacctaa  9900
tgtctccct  gtggaaaat  ctcaataag  aagtgctaa  tgaggtaga  aattgtgtt  9960
tccttggcc  agtttagcc  gataaggct  cagagctgg  attcttgtc  ttatgaatg  10020
ctttcttag  tggcgctgt  gtgccacac  gctcttcta  aagtccgag  ggacaccct  10080
tatatcgcc  agtagcgtc  caggatgag  tggtgtcat  atgttatgg  ttgtacttc  10140
cttgttgac  aaagctcag  cttgaagca  gcatgggaa  taatcagct  gcttattgt  10200
ccctgcacc  gcagagcac  gactaggcg  gggacagtt  gctgggcga  ttaatgggt  10260
gttctgttc  acagtggag  cgtcagaca  agcctggcc  aactaaact  tggtcagta  10320
tgttctcat  cctgtcacc  ggcaggaac  aactgtgtg  taaaatgga  gctttgctt  10380
cttactaag  tgagagctc  tgaaccttt  atctttttt  tttttaatg  agctttctt  10440
tatatcttt  gtagctttt  atttatata  caatctcaa  cacgcagaa  aaaaggtaa  10500
tctagtgca  agaacttct  taccccttt  agccagact  tcggcactt  tgcttgcct  10560
acatcccca  atacagctt  cgtgctgac  gtagttgca  acagcatcc  atgtacttc  10620
aaatgccag  gtgtattgc  caagaacaa  agcattatt  taaccccct  tccatcttc  10680
gatctgtcc  tgttctgaa  gtctcccgc  atggcagaa  tttgaggtg  aggggtgtc  10740
gttatattg  cttaaatga  aaaaggtta  gcagtcatc  gttccttgt  tctgtacag  10800
accgaagtg  gggcagcac  aacaactca  caacaatgt  ttcagaggt  gagacctcg  10860
agggcgtcg  tgagtcaga  aacaactct  cggcaccag  aaaggaaaa  cataccaag  10920
gagtgacgg  agctggcct  tgctgtcag  aggcctcgc  cagcacctg  cctcacccc  10980
gtcatcgtg  ttggttcag  ctgatgcga  aagggaatg  tcgtcagca  taagggccc  11040
gctgcacaa  ttccttagc  tctcattag  gtcctgtca  tggctaagt  atttcctat  11100
tcttactat  tttgctaat  aaccagttc  taggatgtg  ggtgataca  aataatttc  11160
ttaaaaaaa  aaaatactg  tagagacta  accacaaga  aaccagatt  tttctcatt  11220
taacagatg  agtgtgtga  tacacagga  ccttcctag  ttccattgt  cttatgatg  11280
tatttttct  ccttatcca  ttattgatg  aactttatc  tgtgtaatt  tgttaaata  11340
aaaactggg  ggcagaagc  ggtggtgga  ctctgagtt  aaggcatcc  gtctacaga  11400
tgagttcca  gacagccag  gctacacag  aaccccgtc  caaagacaa  aagaaaaag  11460
aaccaacca  gatcttggt  tgtctctca  ctatctcat  ttcccacaa  taggcccat  11520
cacatatca  ctgggagga  ggcagctct  tctgggata  attaagtat  ggttcttcc  11580
agctaggtg  ctacaaagc  aagcgtcat  attggtgct  gctaacaga  accaatgca  11640
gcactcttg  ggagaccag  gtaagtgtc  tgtcactga  ttcttgtgt  agattgtcc  11700
atcttgccc  gtgctcact  acaggctca  ttactcaca  tggactgga  tagtgtctg  11760
gcagctcct  tttcctgct  catcgtggg  cttttagtc  tttctggag  actggaaag  11820
gctactgtc  cacccaaaa  tcatctccc  cagaatggc  gacctttct  agctcctga  11880
ggaagggac  aaggaagca  atgaccggg  agaaaatac  cagtttgtc  aagacttct  11940
gaaaggaaa  attaagaag  agctattta  gtttgtgcc  ctcagtcag  tggggttgg  12000
ttctaactt  aataagggg  gggaagtgg  gtggcttag  cagttgagg  agttgtcat  12060
caaccactc  aggaagaag  tgctgggtc  tttctactt  tttcttgga  acagtctgg  12120
tggatatat  gatggatat  tatatatat  tccgtccac  atcccagcc  tatatttgt  12180
ttcctggtg  taagcctat  ctagctaga  ggagtaaca  aaatatatt  gcaaatatt  12240
actagaagc  tcctaggtg  attaagtag  taatatatt  aaaaaggac  acagttgga  12300
ctttgggaa  tggacaagt  gcttttgtc  tgagctact  ttaaaactg  tggtgatgg  12360
ggtggggac  ggagagttg  ctcagtggt  aagagtact  actgctctt  agaggtcct  12420
gttcaattc  taggaacac  tagtggctc  caaccatct  taatgggat  tgatgccct  12480
ttttggcat  cagataaag  actcatata  atataataa  ctttaaaaa  aaaaaaaac  12540
aagcttagt  ggttctaga  ctgctgctg  cttatagct  tttcccaca  tcttccatc  12600
cactcacag  tggccacca  tgcacttta  ttcacatac  cagcccttg  ggaggaaat  12660
gatcgcaac  aggaccacc  agccttcgc  cccttatat  tccccacgg  actacaccg  12720
aaggaagca  tgatcaagg  catggagta  ttctttggt  aaaactggg  ggagcaggt  12780
aagtgctcc  aggctgccc  gaagtatgt  gatcggatt  actacgtag  acagaatga  12840
ccagagctg  tggtggccc  tgcttacac  cgttacatg  gggaccttt  gggaggcca  12900
gtgctgaag  aggtggctc  gcgggcact  aaactcccc  gcactgggg  agggaccca  12960
ttctacctg  tcgagcatg  ggacaatgc  cagcaattc  agcagttct  ccgcgccag  13020
atgaatgcc  tggacctga  tatgaagac  aaagagagg  ttgtggagg  ggccaacaa  13080
gcctttgaa  ataatatgc  ggtattact  ggcactgac  atggaacct  acccatgcg  13140
ttataacct  ggatgcatg  gtagtagag  caaagccag  agtttgttg  gaggctatt  13200
gtagtgtga  aaatgagtt  ctacatgcc  tagaaaaaa  tgagggaac  agttagcca  13260
cagggatca  gggagcagt  gatggctcc  aggcctggc  ggaggcatg  ctagggctg  13320
agcagccgc  ttgagtctg  atagactca  tccctctat  ttaccacag  tattagatt  13380
aggaatgga  agtttcatt  tgtagcaag  attgatata  aaatatcac  taataggag  13440
cagattcat  gggaagtag  ataaagagg  tttacaagt  tcaggtagg  ctgatctta  13500
agaagccat  tctgtcccc  gtacctcag  gttgggaga  aatagctgt  gcactcaag  13560
agagtccaa  gcagcagcc  ccagagctc  cactaagat  tgcagggcg  tgttcagtt  13620
tctggcttg  tgttcatct  gttttcagt  ctgatgagg  gtttctgga  tctagcttc  13680
ccatgggtc  tctgtagag  gtaaattct  agtctccct  gtttaggga  agcctctaa  13740
gattgtttt  gctcctcag  tattcagtg  actggacca  gctggctcc  tgctaacaa  13800
agaaaccct  gaggatggg  tcccagtac  tgatgggaa  ggagatgta  gtaaatgcc  13860
cttttatgc  gctcagcca  acaaaggta  cctgggagg  agcaactgc  ccttccgga  13920
agccatggc  gtgctgagg  agcctagcc  gcagctcat  ctggctgcc  gtgtggcct  13980
ggtagctgg  ctcttggcc  ggtactaca  gtgaaggac  tgtcatgtt  tttgcatcc  14040
atcccaagt  acctcttcc  tccccatct  cacctctgc  caaaactac  acctcaggt  14100
acttttcta  tgctgggtt  gagaaaaca  gcaaccaat  aaagccaga  actagcacc  14160
ctgcctgcc  gcatcttct  tgccaacca  gtacatacc  gacagcggc  gtcgctctg  14220
taacagcca  tgcccgact  cagttcagt  atggacttc  catctggca  tgctccagg  14280
cgtttgcca  ttgggaggc  tgggtacac  gttttctta  cagtacttg  aatagtcat  14340
gccatgctg  gagtgagct  cccacaccc  ggttttgtg  aaaacggtc  tgccagctg  14400
tgggtcagt  ttccaggcc  tttggagta  aagctgtgt  ttcctgcct  aaagcctac  14460
gagcttatc  tgcataacc  ggatctccc  aagaagtct  gttagcctg  tctgtctcc  14520
ctgactaca  ctgccacag  actctaaaa  caaactcca  acactcccc  ccttcctgg  14580
acagtacag  gtcctcaga  acagtggca  gttgcatac  aatggacat  ctctttgat  14640
acactcctt  cccacttcc  agcaccttc  atttccttg  attcatgct  aacaccata  14700
aagatcctt  acatctctg  ttggacctg  gatttttct  actcaaatt  tttgaggtt  14760
cttatttca  aagtacata  ttaaattta  gcaattcat  ctctaaaat  gaaatgtga  14820
gttaaatgt  tttattagt  ggaatctat  ctataaagt  tttgtgtga  aatggtaga  14880
cagcaggga  actcaaaag  cttgagctc  ccacttcac  gttcagaag  ttgatttac  14940
gactgagtg  gagacttca  gtgtgtcat  agatatagc  agtc  14984



<210> 7973
<211> 315
<212> PRT
<213> Rattus norvegicus
<308> P23711
<400> 7973

Met Ser Ser Glu Val Glu Thr Ser Glu Gly Val Asp Glu Ser Glu Asn 
  1               5                  10                  15
Asn Ser Thr Ala Pro Glu Lys Glu Asn His Thr Lys Met Ala Asp Leu 
             20                  25                  30
Ser Glu Leu Leu Lys Glu Gly Thr Lys Glu Ala His Asp Arg Ala Glu 
         35                  40                  45
Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys Glu 
     50                  55                  60
Leu Phe Lys Leu Ala Thr Thr Ala Leu Tyr Phe Thr Tyr Ser Ala Leu 
 65                  70                  75                  80
Glu Glu Glu Met Asp Arg Asn Lys Asp His Pro Ala Phe Ala Pro Leu 
                 85                  90                  95
Tyr Phe Pro Thr Glu Leu His Arg Lys Glu Ala Leu Ile Lys Asp Met 
             100                105                110
Glu Tyr Phe Phe Gly Glu Asn Trp Glu Glu Gln Val Lys Cys Ser Glu 
         115                120                125
Ala Ala Gln Lys Tyr Val Asp Arg Ile His Tyr Val Gly Gln Asn Glu 
     130                135                140
Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Met Gly Asp Leu 
 145                150                155                160
Ser Gly Gly Gln Val Leu Lys Lys Val Ala Gln Arg Ala Leu Lys Leu 
                 165                170                175
Pro Ser Thr Gly Glu Gly Thr Gln Phe Tyr Leu Phe Glu His Val Asp 
             180                185                190
Asn Ala Gln Gln Phe Lys Gln Phe Tyr Arg Ala Arg Met Asn Ala Leu 
         195                200                205
Asp Leu Ser Met Lys Thr Lys Glu Arg Ile Val Glu Glu Ala Asn Lys 
     210                215                220
Ala Phe Glu Tyr Asn Met Gln Ile Phe Ser Glu Leu Asp Gln Ala Gly 
 225                230                235                240
Ser Met Leu Thr Lys Glu Thr Leu Glu Asp Gly Leu Pro Val His Asp 
                 245                250                255
Gly Lys Gly Asp Val Arg Lys Cys Pro Phe Tyr Ala Ala Gln Pro Asp 
             260                265                270
Lys Gly Thr Leu Gly Gly Ser Asn Cys Pro Phe Arg Thr Ala Met Ala 
         275                280                285
Val Leu Arg Lys Pro Ser Leu Gln Leu Ile Leu Ala Ala Ser Val Ala 
     290                295                300
Leu Val Ala Gly Leu Leu Ala Trp Tyr Tyr Met 
 305                310                315



<210> 7974
<211> 977
<212> DNA
<213> Homo sapiens
<308> D21243
<400> 7974

atgtcagcg  aagtggaaa  ctcagaggg  gtagacgag  cagaaaaaa  gaactctgg  60
gccctagaa  aggagaacc  aatgagaat  gctgacctc  cggagctcc  gaaggaagg  120
accaaggaa  cacacgacc  ggcagaaaa  acccagttt  tcaaggact  cttgaaagg  180
aacattaag  aggagctgt  taagctggc  accacggca  tttacttca  atactcagc  240
ctcgaggag  aaatggagc  caacaagga  catccagcc  ttgcccctt  gtacttccc  300
atggagctg  accggaagg  ggcgctgac  aaggacatg  agtatttct  tggtgaaaa  360
tgggaggag  aggtgcagt  ccccaaggc  gcccagaag  acgtggagc  gatccacta  420
atagggcag  acgagccgg  gctactggt  gcccatgca  acacccgct  catggggga  480
ctctcgggg  gccaggtgc  gaagaaggt  gcccagcga  cactgaaac  ccccagcac  540
ggggaaggg  cccagttct  cctgtttga  aatgtggac  atgcccagc  gttcaagca  600
ctctaccgg  ccaggatga  cgccctgga  ctgaacatg  agaccaaag  gaggatcgt  660
gaggaggcc  acaaggctt  tgagtataa  atgcagata  tcaatgaac  ggaccaggc  720
ggctccaca  tggccagag  gaccttgga  gatgggttc  ctgtacacg  tgggaaagg  780
gacatgcgt  aatgccctt  ctacgctgc  gaacaagac  aaggtgccc  ggagggcag  840
agctgtccc  tccgaacag  tatggctgt  ctgaggaag  ccagcctcc  gttcatcct  900
gccgctggt  tggccctag  tgctggact  ttggcctgg  actacatgt  aagcaccca  960
catgccaca  cggtacc  977



<210> 7975
<211> 316
<212> PRT
<213> Homo sapiens
<308> P30519
<400> 7975

Met Ser Ala Glu Val Glu Thr Ser Glu Gly Val Asp Glu Ser Glu Lys 
  1               5                  10                  15
Lys Asn Ser Gly Ala Leu Glu Lys Glu Asn Gln Met Arg Met Ala Asp 
             20                  25                  30
Leu Ser Glu Leu Leu Lys Glu Gly Thr Lys Glu Ala His Asp Arg Ala 
         35                  40                  45
Glu Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys 
     50                  55                  60
Glu Leu Phe Lys Leu Ala Thr Thr Ala Leu Tyr Phe Thr Tyr Ser Ala 
 65                  70                  75                  80
Leu Glu Glu Glu Met Glu Arg Asn Lys Asp His Pro Ala Phe Ala Pro 
                 85                  90                  95
Leu Tyr Phe Pro Met Glu Leu His Arg Lys Glu Ala Leu Thr Lys Asp 
             100                105                110
Met Glu Tyr Phe Phe Gly Glu Asn Trp Glu Glu Gln Val Gln Cys Pro 
         115                120                125
Lys Ala Ala Gln Lys Tyr Val Glu Arg Ile His Tyr Ile Gly Gln Asn 
     130                135                140
Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Met Gly Asp 
 145                150                155                160
Leu Ser Gly Gly Gln Val Leu Lys Lys Val Ala Gln Arg Ala Leu Lys 
                 165                170                175
Leu Pro Ser Thr Gly Glu Gly Thr Gln Phe Tyr Leu Phe Glu Asn Val 
             180                185                190
Asp Asn Ala Gln Gln Phe Lys Gln Leu Tyr Arg Ala Arg Met Asn Ala 
         195                200                205
Leu Asp Leu Asn Met Lys Thr Lys Glu Arg Ile Val Glu Glu Ala Asn 
     210                215                220
Lys Ala Phe Glu Tyr Asn Met Gln Ile Phe Asn Glu Leu Asp Gln Ala 
 225                230                235                240
Gly Ser Thr Leu Ala Arg Glu Thr Leu Glu Asp Gly Phe Pro Val His 
                 245                250                255
Asp Gly Lys Gly Asp Met Arg Lys Cys Pro Phe Tyr Ala Ala Glu Gln 
             260                265                270
Asp Lys Gly Ala Leu Glu Gly Ser Ser Cys Pro Phe Arg Thr Ala Met 
         275                280                285
Ala Val Leu Arg Lys Pro Ser Leu Gln Phe Ile Leu Ala Ala Gly Val 
     290                295                300
Ala Leu Ala Ala Gly Leu Leu Ala Trp Tyr Tyr Met 
 305                310                315



<210> 7976
<211> 14984
<212> DNA
<213> Rattus norvegicus
<308> U05013
<400> 7976

aagcttgtg  tttaactat  gccacatcc  tgtgatgcc  cttgtctgg  gtagccagt  60
ggcttctct  ttgttgacc  atctgttag  ttttgtcaa  tgcttgata  tgttgaggc  120
catctctca  taccccgtc  gtggagctc  tcctcagta  cccatgtct  gcctcttgt  180
tgttgtgat  gcacacatg  tggactgct  tcgagaagg  gtctgggca  atctgctgt  240
agagctgct  aactcattt  ccagagact  cagatggag  agactcgct  caggccgta  300
atagtgtag  gtgatacaa  cgctgaaat  tgtacctaa  tcaatagtc  agactactc  360
tgtaaatgg  agatggctg  ggggttgga  agactatat  tgggaatct  ccacttagg  420
aaataacac  aaatttctg  tgtagatca  gtaaatgca  ggcagcagc  gtttcttct  480
cctctcaat  cttggaagt  acatcgagg  gcctagtgc  aagttctgc  aagtaatca  540
tgtcactat  gggtttgtt  ttttttaat  tttaaatat  attacgagg  atattgcaa  600
tactttatg  taacagtgg  tgattatga  tttatctta  aaatttgac  atacataga  660
catttgata  gatggttgt  ttatataca  aaggttctg  tttcagtcc  cagcaaaaa  720
aaaaaaagg  tgattgtat  aaagtacat  cctgtatat  ggtctgcat  gagtgttgc  780
ttgagtgtt  ttaaaccca  tcagtcacc  acccaccca  atcacacac  cagctccat  840
cacacaggg  ttctctgtg  agttctggc  gtcctggga  ttactcgga  tccaggttg  900
cctcaaact  agagatcca  ctgcttctg  ttcccaagt  ctgggatta  aggctctca  960
caccactgt  ccgaatctt  tttttaatt  tgtgtgtat  catctgagt  ttggtgtgg  1020
gcctgcaga  gccaggaga  ggcgtcaga  tcccaggag  tagagttat  ggtggctgt  1080
aatactgaa  agagtgaat  agtttctca  caagaacag  ctgtgctct  aattgctga  1140
ccatctctc  agctccaga  ctttttgtc  tagaagaaa  ttgatgagt  tgtacttgg  1200
tgtcttcct  tgggacata  ttgtctgta  gtaaatcaa  ccttatttg  tgagaacac  1260
gttgaagac  cccactcct  gagattcct  gtgccttgc  cattaaggt  gaaaagtat  1320
agatgaagt  agtctgaca  cccctcaag  ataggctgt  ctaagaaat  cagccgttt  1380
attctcatc  gtcagctgt  ctttattct  aactgccat  gctaccaag  tgtgtaaac  1440
taaaacagc  attggaagt  cttgatctt  tcaggaatg  cactgttag  aagtctcga  1500
taatcccat  ctctgaagg  ccctaggaa  tcatgtacg  nccttgcaa  aactagatg  1560
atgtagaag  taccagttg  taaagtctt  ttctgtgaa  gttgctgat  ttacagaac  1620
tttctctca  ccctcttac  ctaccattt  caaacatac  ttttcttaa  aaaatttaa  1680
attaggttt  ttcattttt  ttttagttt  atgtgtata  atatgtatg  gtaccattt  1740
cattcctgg  gcccacagg  gttcagaat  gggcattgg  ttcccctgg  ctggagtta  1800
agatggtgt  aactaccat  tgtgcactg  gaaatgaac  caggccctc  gtaagagag  1860
aagtgctct  agccccatc  gtatatata  attttcaga  gcaggtagg  ctgcttaga  1920
ttttaagta  tcactacac  gttgacaca  agatggttc  ctccctccc  ctctctcac  1980
tagctctgc  tgcctgttt  ccaactact  ggattaaaa  ccttcaacc  ccacctccc  2040
gatacacac  gagatccct  gagctcacc  agagttctc  ttctcagaa  caccactcc  2100
gagtgattc  tgtaactag  tctttgttt  tctcaatca  tatggcaac  agtgctata  2160
agatgtgga  accctattg  gacctcttt  gtgttggtt  gctctgatt  tattatcca  2220
taaggcctg  taagtctgg  tatttctct  caggcacgg  gtgttgggg  gtgccatct  2280
ccctttggg  ccaccttgg  ttgccctct  agcaaagtt  gccttacca  ggagcagtc  2340
tcttggatt  tataatttg  atgagccaa  gtaggtgtt  gagagacag  aagtaacaa  2400
tctgtgtgt  tgtgtgtgt  tgtgtgtgt  cgcgcggcg  gcatgtgca  gcccaagtg  2460
ctgcaagca  atgagacca  aghacactg  gtgccttct  agtcttggg  cacacttag  2520
tgttgaaac  ggtttctca  taaatttgt  gctcattga  gtggttagc  ggctggtta  2580
tgagctcca  ggatctgcc  ttctcctca  cctcagaac  gaagccata  atatgccac  2640
gtttctatg  gggtcatga  atctgaatg  aggtccttg  tgtttttac  caccaagct  2700
tgtcctcag  ccccagcaa  gcatttata  ctcagaaat  atagggtca  gcttttcat  2760
ctgaaacaa  ctatagttt  ttaccttcc  gtaggaata  atagtgtag  ctggcagtg  2820
acctcagtt  ctgtgtagc  tggagtgtg  ggtaacact  actcacacg  gtgaaccag  2880
gaaaactgt  ggggacaca  gaagaacct  ttaccttct  aatgactcg  gtttagttc  2940
aacttgact  ttaggtgtt  catgtagcc  aagctggcc  cttatttac  ttgtagcca  3000
gaatgacct  gaagttttg  tcttccggc  tctccctcc  ccctcagag  gctaggatt  3060
tgtaccaga  tgtaccagc  tgctccata  gcagtgctg  ggatttaac  caggacttt  3120
tcttatgct  ggcaaacac  gtacagctg  gccacagcc  aaccgaatc  aattttagt  3180
catcttccc  ctcttaagt  gactaagga  caacgccag  cctctgcgc  tgttcatta  3240
cgtcttctc  tagattatt  tgtgtcatt  tatagatct  tcatgctat  ccttgtggt  3300
ctctcgtcg  tttccccta  agaagaata  cttctcaac  cgtttttag  gttactgga  3360
aggaaagta  ctgggagct  ggttgcatt  gagcatcta  tcgctgact  tttccctcc  3420
actagaaat  gtgattctt  tagggacca  tatcagctc  ggacacccc  agaccaggt  3480
ctcagcaca  agatgtatt  gccctagag  tctaggaat  agagacaaa  ataggagag  3540
ggatgagga  aagagagag  gggaaggga  atttgtcat  ggggacaaa  gacagcctc  3600
ggatagaga  gacacagat  tagctcata  gcaaatcgt  ttaggatga  gtgtttaat  3660
ttaactgag  atgttaatt  agtgagcca  agaggtttt  attgattac  gacttcaat  3720
ctttgatag  tggaagttg  tattcagct  aggaagaga  gtggcctaa  gagggaatg  3780
tgatatcac  cacacacac  cacacacac  cacacacac  cacacacac  cacacacac  3840
cacacgtac  ttaacatac  tgtagggag  aggaggagt  tgctgttga  ttcatttat  3900
gtaggaatg  ctacactcc  tccctccct  ccccctggt  tgtgatgat  agtaagctt  3960
ttgtttaac  gggggtggt  acatagggc  agatggtgc  agttctata  aggagtaaa  4020
tcttgaact  tagacagcc  tctaggaag  aggcaggga  tcacaatgt  gataagtct  4080
atactgagc  gaaatctat  cagagggaa  tatgatcaa  tcttggtga  gaatgctta  4140
aacagccac  tagcctccc  tcccatatg  gaataacgg  gacttgtac  gtggacata  4200
actcattgt  gctgggtgc  actacttaa  gagtcaggc  tacaacgtt  gtctcattc  4260
agggagcag  taactctga  agtcctttt  cgtgtctcg  acctgctcc  ttccttcag  4320
tagaatgat  caagaagtc  ttattattc  tagatcatc  gattgagaa  tgaaccatg  4380
tatagtcct  agttacatt  cgctagcag  agtgctctg  attacccgg  cttgtgaaa  4440
ttttggagc  agtctccac  aaggagagt  tctttgaat  acatgttat  tcagaaagt  4500
atggtgcct  tgaggtgga  gttctatct  ctaggtggg  ctctaggaa  ctcttctgg  4560
agcttctgt  aatggaact  gctgcttca  tcattcagg  gttagcatg  gacagcagc  4620
gattggaaa  acagctggc  gtctgagga  gtgagtgga  tagcagtca  tgttttaaa  4680
ggggagggg  acagaagtg  ctttctgga  cttgtgata  cagaagggt  aaggactga  4740
ttccttgtt  ttagttgag  acatatctt  tttcttttt  ttttttttt  ttttttttt  4800
tggttcttt  tttcggtgc  ggggaccga  cccaggacc  tgcgcttcc  aggcaagag  4860
tctaccact  agctaaatc  ccaacccct  gttgaggac  tatcttaac  agttttttg  4920
ttacaccat  ctaattcaa  tcctatctg  gtttcctct  taccctttc  ttcctgatt  4980
gtgtcctac  cttttttct  cctatagaa  cacgctaca  aaaagagac  accagttgg  5040
taagctgtc  aacagaagc  gactgaaga  ctttcccgt  tcctgtcgt  gtgacgtgg  5100
tacatgctg  tgcagtcca  gctggcgac  aggtgcacc  ccacaccgc  ccccgggcc  5160
gcagttttc  gttagagag  tgtggtcag  gtttggctt  tcgtgtgtg  gtgtgtgtg  5220
gtgtgtgtg  gtgcgcaca  ccacagctt  ggtagcttg  catagctgt  ctagccctc  5280
actagttta  tgtcctttg  ggagcttag  gtccttggc  gtttgactg  atttatctt  5340
tagtgtgac  gtatataat  ttgtacaga  tgctatgac  ttttaaagg  gtatatgct  5400
gagtaaaca  atcagcgag  ggtcccgga  atgtagctt  tcagaggtt  aagataatt  5460
tttctactg  ggcaaggta  cctcttagt  ttaccctat  tggttactc  cttgaggaa  5520
ggacacata  tgtttccct  agcagtaga  tatgttggt  gaaagtgat  ctgagcctt  5580
ccagctaag  gagctttca  accctttaa  gactcagta  tcttcgaag  gaaataaat  5640
agtaaattg  acttgtagt  tagaaaact  aaaatgaca  acagcaggt  attagtatt  5700
ttttattgt  ttaaaatac  tattgtaaa  tagatgcgg  gatacgtgc  tgtgatcct  5760
gtaagctga  gtgaggctg  aggattgag  ttgaaagtc  tctgggtta  ctttaaagg  5820
cgggcaggg  ttggggatt  agctcagtg  tagagcgtt  cctagcaag  acaaggccc  5880
gggttcggt  cccagctct  aaaaaaaga  aaggggggg  aaaaaaagg  cgggcaaat  5940
gatctctgt  agttcaagg  catacatgg  tccaggatg  cagaggtac  gtgtaagac  6000
ctctctctg  gagagagag  gagagagag  gagagagag  gagagagag  gagagagag  6060
gggggaggg  gaggaagga  ggaaggaag  aaatagcat  gcctagagc  agcatggct  6120
gaccctact  tatagctca  gctattttc  atctcaagg  atgatacat  ctggttgat  6180
tatttaact  cttccctcc  tccctaccc  tttataggc  ttgaacttt  tttagccag  6240
gataacctt  aactcctgt  tttactccc  aagtactag  attacaggc  tgcgcagta  6300
rcaccttgc  ccctccccc  ctctcttct  tccttcttc  cttcctacc  acctaccta  6360
ctacctacc  acctaccta  ctacctacc  agtttagag  gtgttttgt  taacatcag  6420
aaggatttc  agaaagccc  gtgttccct  tcctggagc  aaatagttg  aaagacagt  6480
gtagccatt  tactggctg  gaagactga  gtaggggct  gcagatggt  aaattgaaa  6540
ggatgtatg  gaggatggc  cggggtggg  gctgacaca  acaaattaa  tgactcaga  6600
tgtgaaact  gtgattggg  accatgaaa  ccaactctt  cttttcttt  gtatttttt  6660
taaccataa  cagctttat  aaagatgct  ttcataaac  atcatggta  ttcaggcaa  6720
acatgggca  acagtcaac  atatacagg  acttccaaa  tcccttctt  tatagacta  6780
caaaatcag  aatccacta  aaaacccaa  gaagtcttc  ttcagtgct  tgaaagggg  6840
agtagctta  agtgagggt  gacatttca  gttaaggag  ttgtttaac  actttccac  6900
agccgaccc  gactgtcag  actgaacat  gcagaatct  aagatccac  gtcttttac  6960
aaaggaacc  gtgctcttc  gagaacact  aaagtcact  caaagtcca  gtgcccaat  7020
gactagaaa  ccaattttg  gggtgaggc  ccaacgggt  tctggtttt  agggaatta  7080
gtctgtgtt  atggtacgg  gggagggaa  aggatatag  aatgaattt  gagtttcca  7140
agaccacag  ccttggtgg  tacccacgc  agaccaggt  gtccttttg  aattatcag  7200
gaaaggggt  ttctgtcct  aattcagct  gggtgatat  ttgttggtg  cacatgatc  7260
ttcccccca  ccccaacaa  gaagtgttc  tgtgctaac  atatagtta  aaaaaaaaa  7320
gtaaaacaa  attctgcat  tttataaaa  ttgataaaa  atagtattt  aaactgtgc  7380
gtcaccaga  gtacagagt  ttcaaaaat  cacacacgt  tcttggcct  tccagcacc  7440
tcagctttc  gtgcctggt  tgtgttggc  tctccgttg  ccgcatggt  accggcatt  7500
gctctcccc  tctctccct  ctctgcagg  ccgttttag  cctgggcta  ggctttgga  7560
gagcaggtt  ggcagaccc  ccttgcaga  ccctggggc  cctccttca  cttggcttt  7620
tctccttta  cgtcccctt  agcctttct  ttgggcatg  cagtggcag  ggatgtcgg  7680
gctgagcac  ggtttacag  ggccgacgg  tttggtcca  tccggggtc  tcctcgctg  7740
ttcttcaca  tgctcttct  ttgtatttt  aaaagatga  aagggcctt  ttgttcaag  7800
aaattgcac  cccagaatg  gcacttagt  ccagataaa  cagcgacta  attttagtc  7860
ctgctgttc  ctgtaataa  tggggtaca  gtatcattc  cagaactat  gaagtgata  7920
attacatta  tattacttt  ctcttttat  tacctcact  catggtaac  tttgtgact  7980
tgcttgtcc  tgccattgt  atgctgtac  ttgaaaagc  ggggatctg  aattctaag  8040
tgtcacagt  cagcttaga  gctctggga  actttaccg  attgtactc  tctcttctg  8100
gtaaccggg  ctctcatgt  gtactcttt  ccttgttgc  atctgtcac  gagagacca  8160
aaacatttc  tgtctatta  ggtcccaga  gtgtgggat  gcctccttc  actttcact  8220
ctcctcccc  accccacct  ctttcctgc  ctttctttg  gcatttggt  ttttgtttg  8280
ttgttttca  ggtcttaat  agaggccaa  cctactctg  cttggtacc  gcctacatc  8340
aaaaaaaaa  aaaaaacct  agaacttga  ctgcagctg  acccaagct  ctctcaaat  8400
ccagggagg  cctcatggc  tgtcattag  ccatacccc  gagttactc  ctagcaaca  8460
ttaatcaaa  atcagtctg  ttgtttctt  gtgagacca  ttgtgattg  tcagtctta  8520
ttcaggaca  ctacctgta  gtgcttgcc  ggctgaaca  cccctatgt  agggttggg  8580
tgaaggaga  cccaagccc  agctttaat  aagagacct  aatgtgatt  cattggaaa  8640
ggccccttg  tgtctttgg  attcacgaa  acttctggg  ataacatta  taggtacgc  8700
aatgggctg  aactcgtta  agacttagc  ttatagatc  ggccttgaa  ttgcagtga  8760
cctcttgct  ctgtaaatc  acattaatt  tttgcaaac  cttagaagg  ccatgtagg  8820
gtcatccta  acctgacaa  gcttgcctc  gccattcct  agaaacacg  cacggcagc  8880
ttgcactac  ttactgctg  accacatcc  aactctgag  ccttgcgtt  ttgacggtt  8940
ttctagaag  ctcctccat  tttgatggc  atctgcctt  acattctga  gggcagttg  9000
gtcccatag  tctgaagta  gtatgcttt  gagtcaagc  aatgttgtt  gtactatgt  9060
agtttcatt  aacctcaat  ggaatgcaa  tagaagacc  agcttgttg  cacatgtct  9120
taaccagta  tcaggaggc  gaggcatta  gattagcac  agtttagtt  gggctatag  9180
tctacttca  aaaaggctt  ggaagtgca  gatgtgtgt  aaaaaaaaa  ttgaagggg  9240
tggagagat  gctcagtag  agaatactt  gtgctctta  atcttataa  gaactaggg  9300
tcagttctc  acacccaca  aggtctcac  actctagtt  caaggcatt  tctacacca  9360
cttttgact  ttctggaca  caggcatgc  catgacaca  aaatgcatg  aggtaaaat  9420
ggtatatat  aggttaaaa  aaatccgct  aaatttttt  taaaaactg  ggactgtgc  9480
gagcaaacc  cacacatag  ctaaaaacg  aaagatggc  gctgggtcc  tagagcatg  9540
actaatgtg  ttctgtagg  gagatatgt  ttatggtat  ttttgtttt  gttttctcc  9600
tttccaaga  cttgctttt  ctttttttc  tttcctttt  ttccttttt  tgggggggt  9660
ggggtgggg  caaggtttc  ctgtgtact  tttactgtc  tggaacttg  tctgtagac  9720
aggctgcct  aaactcaga  gtctatctg  ttctgcctc  caaggactg  ttaaaagag  9780
tgccatcac  gcctggctc  aaggagttt  cacagtgct  gacatttga  caaaggtct  9840
acacatgtt  gccaagcac  ttagcctga  ctacataca  tcactttat  ggcacctaa  9900
tgtctccct  gtggaaaat  ctcaataag  aagtgctaa  tgaggtaga  aattgtgtt  9960
tccttggcc  agtttagcc  gataaggct  cagagctgg  attcttgtc  ttatgaatg  10020
ctttcttag  tggcgctgt  gtgccacac  gctcttcta  aagtccgag  ggacaccct  10080
tatatcgcc  agtagcgtc  caggatgag  tggtgtcat  atgttatgg  ttgtacttc  10140
cttgttgac  aaagctcag  cttgaagca  gcatgggaa  taatcagct  gcttattgt  10200
ccctgcacc  gcagagcac  gactaggcg  gggacagtt  gctgggcga  ttaatgggt  10260
gttctgttc  acagtggag  cgtcagaca  agcctggcc  aactaaact  tggtcagta  10320
tgttctcat  cctgtcacc  ggcaggaac  aactgtgtg  taaaatgga  gctttgctt  10380
cttactaag  tgagagctc  tgaaccttt  atctttttt  tttttaatg  agctttctt  10440
tatatcttt  gtagctttt  atttatata  caatctcaa  cacgcagaa  aaaaggtaa  10500
tctagtgca  agaacttct  taccccttt  agccagact  tcggcactt  tgcttgcct  10560
acatcccca  atacagctt  cgtgctgac  gtagttgca  acagcatcc  atgtacttc  10620
aaatgccag  gtgtattgc  caagaacaa  agcattatt  taaccccct  tccatcttc  10680
gatctgtcc  tgttctgaa  gtctcccgc  atggcagaa  tttgaggtg  aggggtgtc  10740
gttatattg  cttaaatga  aaaaggtta  gcagtcatc  gttccttgt  tctgtacag  10800
accgaagtg  gggcagcac  aacaactca  caacaatgt  ttcagaggt  gagacctcg  10860
agggcgtcg  tgagtcaga  aacaactct  cggcaccag  aaaggaaaa  cataccaag  10920
gagtgacgg  agctggcct  tgctgtcag  aggcctcgc  cagcacctg  cctcacccc  10980
gtcatcgtg  ttggttcag  ctgatgcga  aagggaatg  tcgtcagca  taagggccc  11040
gctgcacaa  ttccttagc  tctcattag  gtcctgtca  tggctaagt  atttcctat  11100
tcttactat  tttgctaat  aaccagttc  taggatgtg  ggtgataca  aataatttc  11160
ttaaaaaaa  aaaatactg  tagagacta  accacaaga  aaccagatt  tttctcatt  11220
taacagatg  agtgtgtga  tacacagga  ccttcctag  ttccattgt  cttatgatg  11280
tatttttct  ccttatcca  ttattgatg  aactttatc  tgtgtaatt  tgttaaata  11340
aaaactggg  ggcagaagc  ggtggtgga  ctctgagtt  aaggcatcc  gtctacaga  11400
tgagttcca  gacagccag  gctacacag  aaccccgtc  caaagacaa  aagaaaaag  11460
aaccaacca  gatcttggt  tgtctctca  ctatctcat  ttcccacaa  taggcccat  11520
cacatatca  ctgggagga  ggcagctct  tctgggata  attaagtat  ggttcttcc  11580
agctaggtg  ctacaaagc  aagcgtcat  attggtgct  gctaacaga  accaatgca  11640
gcactcttg  ggagaccag  gtaagtgtc  tgtcactga  ttcttgtgt  agattgtcc  11700
atcttgccc  gtgctcact  acaggctca  ttactcaca  tggactgga  tagtgtctg  11760
gcagctcct  tttcctgct  catcgtggg  cttttagtc  tttctggag  actggaaag  11820
gctactgtc  cacccaaaa  tcatctccc  cagaatggc  gacctttct  agctcctga  11880
ggaagggac  aaggaagca  atgaccggg  agaaaatac  cagtttgtc  aagacttct  11940
gaaaggaaa  attaagaag  agctattta  gtttgtgcc  ctcagtcag  tggggttgg  12000
ttctaactt  aataagggg  gggaagtgg  gtggcttag  cagttgagg  agttgtcat  12060
caaccactc  aggaagaag  tgctgggtc  tttctactt  tttcttgga  acagtctgg  12120
tggatatat  gatggatat  tatatatat  tccgtccac  atcccagcc  tatatttgt  12180
ttcctggtg  taagcctat  ctagctaga  ggagtaaca  aaatatatt  gcaaatatt  12240
actagaagc  tcctaggtg  attaagtag  taatatatt  aaaaaggac  acagttgga  12300
ctttgggaa  tggacaagt  gcttttgtc  tgagctact  ttaaaactg  tggtgatgg  12360
ggtggggac  ggagagttg  ctcagtggt  aagagtact  actgctctt  agaggtcct  12420
gttcaattc  taggaacac  tagtggctc  caaccatct  taatgggat  tgatgccct  12480
ttttggcat  cagataaag  actcatata  atataataa  ctttaaaaa  aaaaaaaac  12540
aagcttagt  ggttctaga  ctgctgctg  cttatagct  tttcccaca  tcttccatc  12600
cactcacag  tggccacca  tgcacttta  ttcacatac  cagcccttg  ggaggaaat  12660
gatcgcaac  aggaccacc  agccttcgc  cccttatat  tccccacgg  actacaccg  12720
aaggaagca  tgatcaagg  catggagta  ttctttggt  aaaactggg  ggagcaggt  12780
aagtgctcc  aggctgccc  gaagtatgt  gatcggatt  actacgtag  acagaatga  12840
ccagagctg  tggtggccc  tgcttacac  cgttacatg  gggaccttt  gggaggcca  12900
gtgctgaag  aggtggctc  gcgggcact  aaactcccc  gcactgggg  agggaccca  12960
ttctacctg  tcgagcatg  ggacaatgc  cagcaattc  agcagttct  ccgcgccag  13020
atgaatgcc  tggacctga  tatgaagac  aaagagagg  ttgtggagg  ggccaacaa  13080
gcctttgaa  ataatatgc  ggtattact  ggcactgac  atggaacct  acccatgcg  13140
ttataacct  ggatgcatg  gtagtagag  caaagccag  agtttgttg  gaggctatt  13200
gtagtgtga  aaatgagtt  ctacatgcc  tagaaaaaa  tgagggaac  agttagcca  13260
cagggatca  gggagcagt  gatggctcc  aggcctggc  ggaggcatg  ctagggctg  13320
agcagccgc  ttgagtctg  atagactca  tccctctat  ttaccacag  tattagatt  13380
aggaatgga  agtttcatt  tgtagcaag  attgatata  aaatatcac  taataggag  13440
cagattcat  gggaagtag  ataaagagg  tttacaagt  tcaggtagg  ctgatctta  13500
agaagccat  tctgtcccc  gtacctcag  gttgggaga  aatagctgt  gcactcaag  13560
agagtccaa  gcagcagcc  ccagagctc  cactaagat  tgcagggcg  tgttcagtt  13620
tctggcttg  tgttcatct  gttttcagt  ctgatgagg  gtttctgga  tctagcttc  13680
ccatgggtc  tctgtagag  gtaaattct  agtctccct  gtttaggga  agcctctaa  13740
gattgtttt  gctcctcag  tattcagtg  actggacca  gctggctcc  tgctaacaa  13800
agaaaccct  gaggatggg  tcccagtac  tgatgggaa  ggagatgta  gtaaatgcc  13860
cttttatgc  gctcagcca  acaaaggta  cctgggagg  agcaactgc  ccttccgga  13920
agccatggc  gtgctgagg  agcctagcc  gcagctcat  ctggctgcc  gtgtggcct  13980
ggtagctgg  ctcttggcc  ggtactaca  gtgaaggac  tgtcatgtt  tttgcatcc  14040
atcccaagt  acctcttcc  tccccatct  cacctctgc  caaaactac  acctcaggt  14100
acttttcta  tgctgggtt  gagaaaaca  gcaaccaat  aaagccaga  actagcacc  14160
ctgcctgcc  gcatcttct  tgccaacca  gtacatacc  gacagcggc  gtcgctctg  14220
taacagcca  tgcccgact  cagttcagt  atggacttc  catctggca  tgctccagg  14280
cgtttgcca  ttgggaggc  tgggtacac  gttttctta  cagtacttg  aatagtcat  14340
gccatgctg  gagtgagct  cccacaccc  ggttttgtg  aaaacggtc  tgccagctg  14400
tgggtcagt  ttccaggcc  tttggagta  aagctgtgt  ttcctgcct  aaagcctac  14460
gagcttatc  tgcataacc  ggatctccc  aagaagtct  gttagcctg  tctgtctcc  14520
ctgactaca  ctgccacag  actctaaaa  caaactcca  acactcccc  ccttcctgg  14580
acagtacag  gtcctcaga  acagtggca  gttgcatac  aatggacat  ctctttgat  14640
acactcctt  cccacttcc  agcaccttc  atttccttg  attcatgct  aacaccata  14700
aagatcctt  acatctctg  ttggacctg  gatttttct  actcaaatt  tttgaggtt  14760
cttatttca  aagtacata  ttaaattta  gcaattcat  ctctaaaat  gaaatgtga  14820
gttaaatgt  tttattagt  ggaatctat  ctataaagt  tttgtgtga  aatggtaga  14880
cagcaggga  actcaaaag  cttgagctc  ccacttcac  gttcagaag  ttgatttac  14940
gactgagtg  gagacttca  gtgtgtcat  agatatagc  agtc  14984



<210> 7977
<211> 315
<212> PRT
<213> Rattus norvegicus
<308> P23711
<400> 7977

Met Ser Ser Glu Val Glu Thr Ser Glu Gly Val Asp Glu Ser Glu Asn 
  1               5                  10                  15
Asn Ser Thr Ala Pro Glu Lys Glu Asn His Thr Lys Met Ala Asp Leu 
             20                  25                  30
Ser Glu Leu Leu Lys Glu Gly Thr Lys Glu Ala His Asp Arg Ala Glu 
         35                  40                  45
Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys Glu 
     50                  55                  60
Leu Phe Lys Leu Ala Thr Thr Ala Leu Tyr Phe Thr Tyr Ser Ala Leu 
 65                  70                  75                  80
Glu Glu Glu Met Asp Arg Asn Lys Asp His Pro Ala Phe Ala Pro Leu 
                 85                  90                  95
Tyr Phe Pro Thr Glu Leu His Arg Lys Glu Ala Leu Ile Lys Asp Met 
             100                105                110
Glu Tyr Phe Phe Gly Glu Asn Trp Glu Glu Gln Val Lys Cys Ser Glu 
         115                120                125
Ala Ala Gln Lys Tyr Val Asp Arg Ile His Tyr Val Gly Gln Asn Glu 
     130                135                140
Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Met Gly Asp Leu 
 145                150                155                160
Ser Gly Gly Gln Val Leu Lys Lys Val Ala Gln Arg Ala Leu Lys Leu 
                 165                170                175
Pro Ser Thr Gly Glu Gly Thr Gln Phe Tyr Leu Phe Glu His Val Asp 
             180                185                190
Asn Ala Gln Gln Phe Lys Gln Phe Tyr Arg Ala Arg Met Asn Ala Leu 
         195                200                205
Asp Leu Ser Met Lys Thr Lys Glu Arg Ile Val Glu Glu Ala Asn Lys 
     210                215                220
Ala Phe Glu Tyr Asn Met Gln Ile Phe Ser Glu Leu Asp Gln Ala Gly 
 225                230                235                240
Ser Met Leu Thr Lys Glu Thr Leu Glu Asp Gly Leu Pro Val His Asp 
                 245                250                255
Gly Lys Gly Asp Val Arg Lys Cys Pro Phe Tyr Ala Ala Gln Pro Asp 
             260                265                270
Lys Gly Thr Leu Gly Gly Ser Asn Cys Pro Phe Arg Thr Ala Met Ala 
         275                280                285
Val Leu Arg Lys Pro Ser Leu Gln Leu Ile Leu Ala Ala Ser Val Ala 
     290                295                300
Leu Val Ala Gly Leu Leu Ala Trp Tyr Tyr Met 
 305                310                315



<210> 7978
<211> 977
<212> DNA
<213> Homo sapiens
<308> D21243
<400> 7978

atgtcagcg  aagtggaaa  ctcagaggg  gtagacgag  cagaaaaaa  gaactctgg  60
gccctagaa  aggagaacc  aatgagaat  gctgacctc  cggagctcc  gaaggaagg  120
accaaggaa  cacacgacc  ggcagaaaa  acccagttt  tcaaggact  cttgaaagg  180
aacattaag  aggagctgt  taagctggc  accacggca  tttacttca  atactcagc  240
ctcgaggag  aaatggagc  caacaagga  catccagcc  ttgcccctt  gtacttccc  300
atggagctg  accggaagg  ggcgctgac  aaggacatg  agtatttct  tggtgaaaa  360
tgggaggag  aggtgcagt  ccccaaggc  gcccagaag  acgtggagc  gatccacta  420
atagggcag  acgagccgg  gctactggt  gcccatgca  acacccgct  catggggga  480
ctctcgggg  gccaggtgc  gaagaaggt  gcccagcga  cactgaaac  ccccagcac  540
ggggaaggg  cccagttct  cctgtttga  aatgtggac  atgcccagc  gttcaagca  600
ctctaccgg  ccaggatga  cgccctgga  ctgaacatg  agaccaaag  gaggatcgt  660
gaggaggcc  acaaggctt  tgagtataa  atgcagata  tcaatgaac  ggaccaggc  720
ggctccaca  tggccagag  gaccttgga  gatgggttc  ctgtacacg  tgggaaagg  780
gacatgcgt  aatgccctt  ctacgctgc  gaacaagac  aaggtgccc  ggagggcag  840
agctgtccc  tccgaacag  tatggctgt  ctgaggaag  ccagcctcc  gttcatcct  900
gccgctggt  tggccctag  tgctggact  ttggcctgg  actacatgt  aagcaccca  960
catgccaca  cggtacc  977



<210> 7979
<211> 316
<212> PRT
<213> Homo sapiens
<308> P30519
<400> 7979

Met Ser Ala Glu Val Glu Thr Ser Glu Gly Val Asp Glu Ser Glu Lys 
  1               5                  10                  15
Lys Asn Ser Gly Ala Leu Glu Lys Glu Asn Gln Met Arg Met Ala Asp 
             20                  25                  30
Leu Ser Glu Leu Leu Lys Glu Gly Thr Lys Glu Ala His Asp Arg Ala 
         35                  40                  45
Glu Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys 
     50                  55                  60
Glu Leu Phe Lys Leu Ala Thr Thr Ala Leu Tyr Phe Thr Tyr Ser Ala 
 65                  70                  75                  80
Leu Glu Glu Glu Met Glu Arg Asn Lys Asp His Pro Ala Phe Ala Pro 
                 85                  90                  95
Leu Tyr Phe Pro Met Glu Leu His Arg Lys Glu Ala Leu Thr Lys Asp 
             100                105                110
Met Glu Tyr Phe Phe Gly Glu Asn Trp Glu Glu Gln Val Gln Cys Pro 
         115                120                125
Lys Ala Ala Gln Lys Tyr Val Glu Arg Ile His Tyr Ile Gly Gln Asn 
     130                135                140
Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Met Gly Asp 
 145                150                155                160
Leu Ser Gly Gly Gln Val Leu Lys Lys Val Ala Gln Arg Ala Leu Lys 
                 165                170                175
Leu Pro Ser Thr Gly Glu Gly Thr Gln Phe Tyr Leu Phe Glu Asn Val 
             180                185                190
Asp Asn Ala Gln Gln Phe Lys Gln Leu Tyr Arg Ala Arg Met Asn Ala 
         195                200                205
Leu Asp Leu Asn Met Lys Thr Lys Glu Arg Ile Val Glu Glu Ala Asn 
     210                215                220
Lys Ala Phe Glu Tyr Asn Met Gln Ile Phe Asn Glu Leu Asp Gln Ala 
 225                230                235                240
Gly Ser Thr Leu Ala Arg Glu Thr Leu Glu Asp Gly Phe Pro Val His 
                 245                250                255
Asp Gly Lys Gly Asp Met Arg Lys Cys Pro Phe Tyr Ala Ala Glu Gln 
             260                265                270
Asp Lys Gly Ala Leu Glu Gly Ser Ser Cys Pro Phe Arg Thr Ala Met 
         275                280                285
Ala Val Leu Arg Lys Pro Ser Leu Gln Phe Ile Leu Ala Ala Gly Val 
     290                295                300
Ala Leu Ala Ala Gly Leu Leu Ala Trp Tyr Tyr Met 
 305                310                315



<210> 7980
<211> 843
<212> DNA
<213> Rattus norvegicus
<308> U05014
<400> 7980

gggccgagg  gccgcgggg  tgctggagg  tcgtgggcg  cgtgcagga  acatgtcgg  60
gggcagcag  tgcagccag  ctcccagcc  ggctatccc  actcgccgc  tagccctcg  120
cgacggcgt  cagctcccg  ccggggact  cagcaccac  cccggcggc  cgctcttca  180
caccacccc  ggaggaacc  gaatcatct  tgaccggaa  ttcctgatg  agtgtcgga  240
ctcgcctgt  gccaaaaca  ccccaaagg  cctgccaac  attccaggg  tcactagcc  300
taccagcga  gagcctccc  tgcaggcca  ccagagcca  ctgcacagc  gcccggaag  360
taagcgggc  ggtggtgaa  agtcacagt  tgagatgga  atttaaggg  ccagccata  420
gacgcagtg  tgcttctgg  cccctgggg  ccttgggag  agagccaca  cagtcaggc  480
ttgtacccg  cagacactg  gtgtggatc  gccacccag  cctgctcct  actcagggc  540
cctgctctg  cttccattt  gtgaatacc  gcacatacc  ccttgtgcc  ctgttgata  600
tgagctgct  ctccagggt  atgactctc  cctacaccc  ccctgcatc  agcgccagc  660
agtggacac  gaggagtct  tcggaatga  ctggcaatt  tagccccaa  ctctggagc  720
cacccacct  accttaggt  ggggtacct  ggaaagcca  cctttactt  tttccctga  780
aggaaataa  agccacatt  accctaggc  cacagccgg  ccctgtctg  aaaaaaaaa  840
aaa  843



<210> 7981
<211> 117
<212> PRT
<213> Rattus norvegicus
<308> AAA86938
<400> 7981

Met Ser Ala Gly Ser Ser Cys Ser Gln Thr Pro Ser Arg Ala Ile Pro 
  1               5                  10                  15
Thr Arg Arg Val Ala Leu Gly Asp Gly Val Gln Leu Pro Pro Gly Asp 
             20                  25                  30
Tyr Ser Thr Thr Pro Gly Gly Thr Leu Phe Ser Thr Thr Pro Gly Gly 
         35                  40                  45
Thr Arg Ile Ile Tyr Asp Arg Lys Phe Leu Met Glu Cys Arg Asn Ser 
     50                  55                  60
Pro Val Ala Lys Thr Pro Pro Lys Asp Leu Pro Thr Ile Pro Gly Val 
 65                  70                  75                  80
Thr Ser Pro Thr Ser Asp Glu Pro Pro Met Gln Ala Ser Gln Ser His 
                 85                  90                  95
Leu His Ser Ser Pro Glu Asp Lys Arg Ala Gly Gly Glu Glu Ser Gln 
             100                105                110
Phe Glu Met Asp Ile 
         115



<210> 7982
<211> 895
<212> DNA
<213> Homo sapiens
<308> NM_004095
<400> 7982

gcggagcga  gctggaggc  cgggagggc  gcgagaggt  cgcgggtgc  gcgcacagg  60
gaccatgtc  gggggcagc  gctgcagcc  gaccccaag  cgggccatc  ccgccactc  120
ccgggtggt  ctcggcgac  gcgtgcagc  cccgcccgg  gactacagc  cgacccccg  180
cggcacgct  ttcagcacc  ccccgggag  taccaggat  atctatgac  ggaaattcc  240
gatggagtg  cggaactca  ctgtgacca  aacaccccc  agggatctg  ccaccattc  300
gggggtcac  agcccttcc  gtgatgagc  ccccatgga  gccagccag  gccacctgc  360
caatagccc  gaagataag  gggcgggcg  tgaagagtc  cagtttgag  tggacattt  420
aagcaccag  catcgtgtg  agcactacc  aggggcccc  cagggcctt  ctgggagga  480
tcccaccag  caggcctta  gaaagtgat  atactgggc  ggcgttggc  tggggtcgg  540
caccccagc  ctttctccc  cactcaggg  acctgcccc  tcctcttcg  gaacaccag  600
agatacctc  ttgtgcctc  actgatgca  gagctgcca  cccaagggg  gtgacccct  660
ccagcacac  ctgcagcca  gggccagga  gtggacaag  acgaaccct  ccttccgaa  720
gatcagcag  tccagcccc  cgctgctgg  ggcgcaacc  ccccttcct  aggttgatg  780
gcttgggaa  gctccctcc  cctccttcc  caagagagg  aataaaagc  accttcgcc  840
taggaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  895



<210> 7983
<211> 118
<212> PRT
<213> Homo sapiens
<308> NP_004086
<400> 7983

Met Ser Gly Gly Ser Ser Cys Ser Gln Thr Pro Ser Arg Ala Ile Pro 
  1               5                  10                  15
Ala Thr Arg Arg Val Val Leu Gly Asp Gly Val Gln Leu Pro Pro Gly 
             20                  25                  30
Asp Tyr Ser Thr Thr Pro Gly Gly Thr Leu Phe Ser Thr Thr Pro Gly 
         35                  40                  45
Gly Thr Arg Ile Ile Tyr Asp Arg Lys Phe Leu Met Glu Cys Arg Asn 
     50                  55                  60
Ser Pro Val Thr Lys Thr Pro Pro Arg Asp Leu Pro Thr Ile Pro Gly 
 65                  70                  75                  80
Val Thr Ser Pro Ser Ser Asp Glu Pro Pro Met Glu Ala Ser Gln Ser 
                 85                  90                  95
His Leu Arg Asn Ser Pro Glu Asp Lys Arg Ala Gly Gly Glu Glu Ser 
             100                105                110
Gln Phe Glu Met Asp Ile 
         115



<210> 7984
<211> 843
<212> DNA
<213> Rattus norvegicus
<308> U05014
<400> 7984

gggccgagg  gccgcgggg  tgctggagg  tcgtgggcg  cgtgcagga  acatgtcgg  60
gggcagcag  tgcagccag  ctcccagcc  ggctatccc  actcgccgc  tagccctcg  120
cgacggcgt  cagctcccg  ccggggact  cagcaccac  cccggcggc  cgctcttca  180
caccacccc  ggaggaacc  gaatcatct  tgaccggaa  ttcctgatg  agtgtcgga  240
ctcgcctgt  gccaaaaca  ccccaaagg  cctgccaac  attccaggg  tcactagcc  300
taccagcga  gagcctccc  tgcaggcca  ccagagcca  ctgcacagc  gcccggaag  360
taagcgggc  ggtggtgaa  agtcacagt  tgagatgga  atttaaggg  ccagccata  420
gacgcagtg  tgcttctgg  cccctgggg  ccttgggag  agagccaca  cagtcaggc  480
ttgtacccg  cagacactg  gtgtggatc  gccacccag  cctgctcct  actcagggc  540
cctgctctg  cttccattt  gtgaatacc  gcacatacc  ccttgtgcc  ctgttgata  600
tgagctgct  ctccagggt  atgactctc  cctacaccc  ccctgcatc  agcgccagc  660
agtggacac  gaggagtct  tcggaatga  ctggcaatt  tagccccaa  ctctggagc  720
cacccacct  accttaggt  ggggtacct  ggaaagcca  cctttactt  tttccctga  780
aggaaataa  agccacatt  accctaggc  cacagccgg  ccctgtctg  aaaaaaaaa  840
aaa  843



<210> 7985
<211> 117
<212> PRT
<213> Rattus norvegicus
<308> AAA86938
<400> 7985

Met Ser Ala Gly Ser Ser Cys Ser Gln Thr Pro Ser Arg Ala Ile Pro 
  1               5                  10                  15
Thr Arg Arg Val Ala Leu Gly Asp Gly Val Gln Leu Pro Pro Gly Asp 
             20                  25                  30
Tyr Ser Thr Thr Pro Gly Gly Thr Leu Phe Ser Thr Thr Pro Gly Gly 
         35                  40                  45
Thr Arg Ile Ile Tyr Asp Arg Lys Phe Leu Met Glu Cys Arg Asn Ser 
     50                  55                  60
Pro Val Ala Lys Thr Pro Pro Lys Asp Leu Pro Thr Ile Pro Gly Val 
 65                  70                  75                  80
Thr Ser Pro Thr Ser Asp Glu Pro Pro Met Gln Ala Ser Gln Ser His 
                 85                  90                  95
Leu His Ser Ser Pro Glu Asp Lys Arg Ala Gly Gly Glu Glu Ser Gln 
             100                105                110
Phe Glu Met Asp Ile 
         115



<210> 7986
<211> 895
<212> DNA
<213> Homo sapiens
<308> NM_004095
<400> 7986

gcggagcga  gctggaggc  cgggagggc  gcgagaggt  cgcgggtgc  gcgcacagg  60
gaccatgtc  gggggcagc  gctgcagcc  gaccccaag  cgggccatc  ccgccactc  120
ccgggtggt  ctcggcgac  gcgtgcagc  cccgcccgg  gactacagc  cgacccccg  180
cggcacgct  ttcagcacc  ccccgggag  taccaggat  atctatgac  ggaaattcc  240
gatggagtg  cggaactca  ctgtgacca  aacaccccc  agggatctg  ccaccattc  300
gggggtcac  agcccttcc  gtgatgagc  ccccatgga  gccagccag  gccacctgc  360
caatagccc  gaagataag  gggcgggcg  tgaagagtc  cagtttgag  tggacattt  420
aagcaccag  catcgtgtg  agcactacc  aggggcccc  cagggcctt  ctgggagga  480
tcccaccag  caggcctta  gaaagtgat  atactgggc  ggcgttggc  tggggtcgg  540
caccccagc  ctttctccc  cactcaggg  acctgcccc  tcctcttcg  gaacaccag  600
agatacctc  ttgtgcctc  actgatgca  gagctgcca  cccaagggg  gtgacccct  660
ccagcacac  ctgcagcca  gggccagga  gtggacaag  acgaaccct  ccttccgaa  720
gatcagcag  tccagcccc  cgctgctgg  ggcgcaacc  ccccttcct  aggttgatg  780
gcttgggaa  gctccctcc  cctccttcc  caagagagg  aataaaagc  accttcgcc  840
taggaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  895



<210> 7987
<211> 118
<212> PRT
<213> Homo sapiens
<308> NP_004086
<400> 7987

Met Ser Gly Gly Ser Ser Cys Ser Gln Thr Pro Ser Arg Ala Ile Pro 
  1               5                  10                  15
Ala Thr Arg Arg Val Val Leu Gly Asp Gly Val Gln Leu Pro Pro Gly 
             20                  25                  30
Asp Tyr Ser Thr Thr Pro Gly Gly Thr Leu Phe Ser Thr Thr Pro Gly 
         35                  40                  45
Gly Thr Arg Ile Ile Tyr Asp Arg Lys Phe Leu Met Glu Cys Arg Asn 
     50                  55                  60
Ser Pro Val Thr Lys Thr Pro Pro Arg Asp Leu Pro Thr Ile Pro Gly 
 65                  70                  75                  80
Val Thr Ser Pro Ser Ser Asp Glu Pro Pro Met Glu Ala Ser Gln Ser 
                 85                  90                  95
His Leu Arg Asn Ser Pro Glu Asp Lys Arg Ala Gly Gly Glu Glu Ser 
             100                105                110
Gln Phe Glu Met Asp Ile 
         115



<210> 7988
<211> 861
<212> DNA
<213> Rattus norvegicus
<308> U05784
<400> 7988

ggcacgagc  aggaccccc  cgcgccatg  cgtccgaga  gaccttcaa  cagcgccgg  60
gcttcgaac  aagagtgga  gatgtccgg  tcatccggg  gcagcaccc  accaagatc  120
cagtgatta  agagcgata  aagggtgag  agcagctgc  cgtcctgga  aagaccaag  180
tccttgtac  tgatcacgt  aatatgagc  aactcatca  gataattag  aggcgcctg  240
agctcaatg  taaccaagc  ttcttcctc  tggtgaatg  gcacagcat  gtgagtgtg  300
ccacaccca  ctctgaagt  tacgagagc  agagagatg  agacggctt  ctgtacatg  360
tctatgcct  ccaggagac  ttcgggaca  cactggctg  tacatacat  tcagctctg  420
aggcaacag  aacaggaag  gagccatgc  tgtgacaga  atacagcca  ttccaacta  480
agcaagcct  tgcttcctg  tacctgcat  gagcccact  tgacactca  accatcccc  540
gtcactcac  cgtgtctga  aatctcagt  agagctgcc  ctgtcacgg  ccggaagcc  600
acacagcca  ctctcgacc  gctccccac  gcacccacc  tccctgcat  caagctgtc  660
ctgctaacc  ccaatgtta  gttacactg  gtaaatccc  actgctgcc  tgtgtgggt  720
gtgtacgtc  tcatgtccc  ggtttataa  tatggtgcg  tcgggaagg  ttcctgtaa  780
gctgctcta  ggatctggc  caggcagcc  ttgtaggac  cctgtactc  gatgcacta  840
gtccaataa  ggcacaact  g  861



<210> 7989
<211> 141
<212> PRT
<213> Rattus norvegicus
<308> Q62625
<400> 7989

Pro Ser Glu Lys Thr Phe Lys Gln Arg Arg Ser Phe Glu Gln Arg Val 
  1               5                  10                  15
Glu Asp Val Arg Leu Ile Arg Glu Gln His Pro Thr Lys Ile Pro Val 
             20                  25                  30
Ile Ile Glu Arg Tyr Lys Gly Glu Lys Gln Leu Pro Val Leu Asp Lys 
         35                  40                  45
Thr Lys Phe Leu Val Pro Asp His Val Asn Met Ser Glu Leu Ile Lys 
     50                  55                  60
Ile Ile Arg Arg Arg Leu Gln Leu Asn Ala Asn Gln Ala Phe Phe Leu 
 65                  70                  75                  80
Leu Val Asn Gly His Ser Met Val Ser Val Ser Thr Pro Ile Ser Glu 
                 85                  90                  95
Val Tyr Glu Ser Glu Arg Asp Glu Asp Gly Phe Leu Tyr Met Val Tyr 
             100                105                110
Ala Ser Gln Glu Thr Phe Gly Thr Ala Leu Ala Val Thr Tyr Met Ser 
         115                120                125
Ala Leu Lys Ala Thr Ala Thr Gly Arg Glu Pro Cys Leu 
     130                135                140



<210> 7990
<211> 460
<212> DNA
<213> Homo sapiens
<308> H28835
<400> 7990

gaacggaca  agcatggtc  gcgtctcca  accaatctc  gaggtgtat  agagtgaga  60
agatgaaga  ggattcctg  acatggtct  tgcctccca  gagacgttc  ggatgaaat  120
gtcagtgta  aaccagaaa  aatgcatct  ttctagaat  gtttaaacc  ttaccaagg  180
aaaaaaagg  gtgttacca  ctgagatcg  tcagttcat  caatcacag  tcatgaaac  240
gtagtgttc  cacctagga  tgttaggaa  ttgtgtttg  gtttcaagc  gaaaaactt  300
agctccaag  gagcacatt  agctttggg  aactatatt  tttaaatgt  aggcttagc  360
ttgtttttc  antttttaa  agttttaaa  antaaanta  ttttgcatt  taaggtttg  420
ccantaaan  aggaccntt  aagttattt  taatggcccc  460



<210> 7991
<211> 125
<212> PRT
<213> Homo sapiens
<308> NP_073729
<400> 7991

Met Pro Ser Glu Lys Thr Phe Lys Gln Arg Arg Thr Phe Glu Gln Arg 
  1               5                  10                  15
Val Glu Asp Val Arg Leu Ile Arg Glu Gln His Pro Thr Lys Ile Pro 
             20                  25                  30
Val Ile Ile Glu Arg Tyr Lys Gly Glu Lys Gln Leu Pro Val Leu Asp 
         35                  40                  45
Lys Thr Lys Phe Leu Val Pro Asp His Val Asn Met Ser Glu Leu Ile 
     50                  55                  60
Lys Ile Ile Arg Arg Arg Leu Gln Leu Asn Ala Asn Gln Ala Phe Phe 
 65                  70                  75                  80
Leu Leu Val Asn Gly His Ser Met Val Ser Val Ser Thr Pro Ile Ser 
                 85                  90                  95
Glu Val Tyr Glu Ser Glu Lys Asp Glu Asp Gly Phe Leu Tyr Met Val 
             100                105                110
Tyr Ala Ser Gln Glu Thr Phe Gly Met Lys Leu Ser Val 
         115                120                125



<210> 7992
<211> 1589
<212> DNA
<213> Rattus norvegicus
<308> U06230
<400> 7992

aattggctt  aaaccagtt  tagggggtt  gaatcagaa  ctctcgatc  ctcaaattg  60
ctcctgatt  cacttcgtg  agggaagat  gaagttcag  ttaagaatg  gttttcaac  120
caaatcaca  ctggaggca  tgttattaa  aatggtata  ggaatatgg  gtctgtgga  180
gaattagac  acagtgtta  cattaaaat  gctaaggag  ccgtgatga  tattaataa  240
cttgggagt  tttttaaac  taccgatgg  tttctggac  ccaaaatat  ctttgcagg  300
ttacctcgg  aggtggaaa  tgcactcat  aagccgatt  atcctcgtc  ggatggatg  360
atacgaggc  ggaacttga  gaaacaagg  gctttgggt  caaaggaaa  agttgaagg  420
aaacaaaat  aacattgct  cctcactgt  gagaagggc  cctactacc  tggttcagg  480
attgctcag  tcagcatag  ctacaataa  gtaactaat  cagaggatt  gcaaataaa  540
gtgaccttg  atattcgcc  gttcactgg  actggggtc  tgcttgctt  agtttctgg  600
gacacagtg  cctttgcct  gtccttggt  gattctggc  ctggaactt  tcaggacat  660
ctggtattt  ttgaaaatt  agtagcagc  cacttagaa  ccataactc  gtgctcgga  720
cagccatcc  agctgaaat  taacattaa  agaaatgga  tggaactgt  gaccccagt  780
agaaaagac  tcatttact  taaagatct  caaaggcaa  tcgccatct  ggacaaaac  840
atgaaagga  ccgtggcca  ttacctggg  ggcgttcca  atatttcct  cagtgccac  900
ccagtgaat  ctttttaca  cggctgcat  gaagtgaac  tcaacgggg  acagttgga  960
ctggatgaa  ccatttcca  acataatga  attagagct  actcctgtc  gtcagtgag  1020
aaaatccag  agaacttct  aagtctgtt  cctgggctt  taatctctc  tttcatatt  1080
taattatgc  cttgttcat  tttccatca  caaatggca  gattacatg  gttatatgc  1140
tgtttaaat  tgatgtggt  ctttgtcct  cagattttt  ttatataag  cgcattttt  1200
aaaagtctt  tactcactg  tgtctagaa  ttaaataac  aaacacatg  aacatttaa  1260
tttcaattt  tttcctata  atcttccag  gcgtcacag  caacataat  tgctccatt  1320
tctttggag  gcgctttga  tacagagac  gccagttcc  gcgcttgct  gacctgttg  1380
ataggacct  ttccctcat  agctcattc  ccagccaga  gtttgaggt  tactctgac  1440
tcctgaagt  ctttcctgg  gtccacaga  aaatctaca  aaacctgaa  gaagtcctc  1500
actacattg  tcatagtgt  gagaaccac  gggccactt  ggaccccaa  gctccccga  1560
actttatcg  tactttcct  ctggaattc  1589



<210> 7993
<211> 3309
<212> DNA
<213> Homo sapiens
<308> M15036
<400> 7993

ctgcagggg  ggggggggg  ggggggggg  ggggggggc  cagcacggc  cagaccgag  60
cgcacaggc  cgcagctcc  ggcgcctag  gcccggtcc  cgccgcgac  cgccaccgt  120
cctgccggc  cctccgcgc  ttcgaaatg  gggtcctgg  tgggcgctg  ggggcgccg  180
tggcgtgtc  cctcctagt  cttcccgtc  cagaggcaa  ccttctgtc  aagcaacag  240
cttcacaag  cctggttag  aagcgtcgt  caaattctt  acttgaaga  accaaacag  300
gtaatcttg  aagagaatg  atcgaagaa  tgtgcaata  agaagaagc  agggaggtc  360
ttgaaaatg  cccggaaac  gattatttt  atccaaaat  cttagtttg  cttcgctct  420
ttcaaactg  gttattcac  gctgcacgt  agtcaacta  tgcttatcc  gacctaaga  480
gctgtgtca  tgccattcc  gaccagtgt  gtcctctgc  atgcaatga  gatggatat  540
tgagctgca  agatggaaa  gcttctttt  cttgcactt  taaaccagg  tggcaagga  600
aaaagtgtg  atttgacat  aatgaatgc  aagatccct  aaatataaa  ggaggttgc  660
gtcaaattt  tgataatac  cctggaagt  accactgtt  ctgtaaaaa  ggttttgtt  720
tgctttcaa  taagaaaga  tgtaaagat  tggatgaat  ctctttgaa  ccaagcatt  780
gtggcacag  tgtgtgcaa  aacatccca  gagattttg  atgtgaatg  cccgaaggc  840
acagatata  tctcaaatc  aagtcttgt  aagatatag  tgaatgctc  gagaacatg  900
gtgctcagc  ttgtgtcaa  taccctgga  gttacactt  ctattgtga  gggaagaaa  960
gattcaaac  tgcccaaga  cagaagagt  gtgaggttg  ttcagtgtg  cttcccttg  1020
accttgaca  aaagtatga  ttactttac  tggcggagc  gtttgcagg  gttgtttta  1080
atttaaaat  tcgtttgcc  gaaatcagc  gattttcag  agaatttga  ttccggaca  1140
atgattcag  aggcgtgat  ctgtacgca  aatctatcg  tcactcagc  tggctcctg  1200
ttgcacttc  tggtggaaa  attgaagtt  agcttaaga  tgaacatac  tccaaaatc  1260
caactggag  tgatgttat  aataatggt  tatggaata  ggtgtctgt  gaagaatta  1320
aacatagta  tagcattaa  atagctaaa  aagctgtga  ggatataaa  aaacctgga  1380
cccttttta  gccggaaaa  ggattgctg  aaaccaaag  atactttgc  ggattccct  1440
ggaaagtgg  aagtgaact  attaaaccg  ttaaccctc  tctagatgg  tgtatacga  1500
gctggaatt  gatgaagca  ggagcttct  gaataaagg  aattattca  gaaaaacaa  1560
ataagcatt  cctggttac  gtggagaag  gctcctact  tcctggttc  ggaattgct  1620
aatttcaca  agattataa  aatgtatcc  gtgctgagg  ttggcatgt  aatgtgacc  1680
tgaatattc  tccatccac  ggcactggt  ttatgcttg  cttggtttc  ggtaacaac  1740
cagtgccct  tgctgtgtc  ttggtggac  ccacctctg  aaaatcaca  gatattctg  1800
tatctgttg  aaatactgt  atatatcgg  tacaggccc  aagtctatg  tccgatcaa  1860
aatctcatc  ggaatttag  gtcaacaga  acaatctgg  gttgtcgac  ccacttaaa  1920
tagaaacca  ctcccatga  gaccttcaa  gacaacttg  cgtcttgga  aaagcaatg  1980
aagcaaaag  ggccacata  ctgggtggc  ttccagatg  tccattcag  gccacacca  2040
tgaatgcct  ttataatgg  tgcatggaa  tgaatatta  tggtgtaca  ttggatctg  2100
atgaagcca  ttctaaaca  aatgatatt  gagctcact  atgtccatc  gtttggaaa  2160
agacaaaga  ttcttaagg  atcttttct  tgcttataa  accttttcc  tgtgtgtaa  2220
tatacttat  tttcaataa  agctgaagg  ttttattta  aatgtgcag  ctttgatta  2280
tttgtggtc  tttcctggg  tttttaaaa  gtcctttgt  aaggaaaaa  attctgttg  2340
gatataaat  acagtaaag  aattcttac  tctcttgct  tctaagaat  gtgaaaaat  2400
acaatttta  atttgaatt  ttttcctac  aatgacagt  tcaattttt  tttgtaaaa  2460
taaatttta  ttttatcat  atgaactag  gtctaaata  ctatgtttt  ttcagaaag  2520
aaggaagta  actcaaaca  aagtgcgtg  aattaaata  tattaatca  aggcagata  2580
tattttgtt  atgtttttg  ttttttcct  atgaaggca  aagagatgg  ggtctatta  2640
atatgaatt  aatggaggg  cctaatgcc  tatttcaaa  caattcctc  gggggacca  2700
ctttggctt  atctttctc  tgtgtggct  cacatttaa  ccagtatct  tattgaatt  2760
gaaaacaag  gggacatat  ttcctgaga  cagcacagg  atcttcttc  tggcagctg  2820
agtctgtca  gatgagata  cagattagg  tggataggt  gggaaatct  aagtgggta  2880
attttttaa  ttttgctgt  tgggtcaca  aaggtctac  ttacaaaag  cagaattca  2940
ggatggaaa  gagaatgaa  aaatgtggg  gttcatagt  ttccttgaa  ccaactttt  3000
attaccaga  taagttgcc  aaatgtgat  gttgaagta  aaaaggaac  atgaaaacc  3060
gaacaaatt  taacaaaag  acaaccaca  agggatata  tgaatatcg  atcattgta  3120
tcaaagaag  aaggaggta  gattgccac  tgcctgctg  tactgtgat  catttcaag  3180
ggcagtttt  tcacgtttg  atctaccat  catagccag  tgtgtatca  atgtttcac  3240
gacagtttt  aacaataaa  tcttttcac  gtattttat  tcacttata  taaatcggt  3300
tataatttt  3309



<210> 7994
<211> 676
<212> PRT
<213> Homo sapiens
<308> P07225
<400> 7994

Met Arg Val Leu Gly Gly Arg Cys Gly Ala Leu Leu Ala Cys Leu Leu 
  1               5                  10                  15
Leu Val Leu Pro Val Ser Glu Ala Asn Phe Leu Ser Lys Gln Gln Ala 
             20                  25                  30
Ser Gln Val Leu Val Arg Lys Arg Arg Ala Asn Ser Leu Leu Glu Glu 
         35                  40                  45
Thr Lys Gln Gly Asn Leu Glu Arg Glu Cys Ile Glu Glu Leu Cys Asn 
     50                  55                  60
Lys Glu Glu Ala Arg Glu Val Phe Glu Asn Asp Pro Glu Thr Asp Tyr 
 65                  70                  75                  80
Phe Tyr Pro Lys Tyr Leu Val Cys Leu Arg Ser Phe Gln Thr Gly Leu 
                 85                  90                  95
Phe Thr Ala Ala Arg Gln Ser Thr Asn Ala Tyr Pro Asp Leu Arg Ser 
             100                105                110
Cys Val Asn Ala Ile Pro Asp Gln Cys Ser Pro Leu Pro Cys Asn Glu 
         115                120                125
Asp Gly Tyr Met Ser Cys Lys Asp Gly Lys Ala Ser Phe Thr Cys Thr 
     130                135                140
Cys Lys Pro Gly Trp Gln Gly Glu Lys Cys Glu Phe Asp Ile Asn Glu 
 145                150                155                160
Cys Lys Asp Pro Ser Asn Ile Asn Gly Gly Cys Ser Gln Ile Cys Asp 
                 165                170                175
Asn Thr Pro Gly Ser Tyr His Cys Ser Cys Lys Asn Gly Phe Val Met 
             180                185                190
Leu Ser Asn Lys Lys Asp Cys Lys Asp Val Asp Glu Cys Ser Leu Lys 
         195                200                205
Pro Ser Ile Cys Gly Thr Ala Val Cys Lys Asn Ile Pro Gly Asp Phe 
     210                215                220
Glu Cys Glu Cys Pro Glu Gly Tyr Arg Tyr Asn Leu Lys Ser Lys Ser 
 225                230                235                240
Cys Glu Asp Ile Asp Glu Cys Ser Glu Asn Met Cys Ala Gln Leu Cys 
                 245                250                255
Val Asn Tyr Pro Gly Gly Tyr Thr Cys Tyr Cys Asp Gly Lys Lys Gly 
             260                265                270
Phe Lys Leu Ala Gln Asp Gln Lys Ser Cys Glu Val Val Ser Val Cys 
         275                280                285
Leu Pro Leu Asn Leu Asp Thr Lys Tyr Glu Leu Leu Tyr Leu Ala Glu 
     290                295                300
Gln Phe Ala Gly Val Val Leu Tyr Leu Lys Phe Arg Leu Pro Glu Ile 
 305                310                315                320
Ser Arg Phe Ser Ala Glu Phe Asp Phe Arg Thr Tyr Asp Ser Glu Gly 
                 325                330                335
Val Ile Leu Tyr Ala Glu Ser Ile Asp His Ser Ala Trp Leu Leu Ile 
             340                345                350
Ala Leu Arg Gly Gly Lys Ile Glu Val Gln Leu Lys Asn Glu His Thr 
         355                360                365
Ser Lys Ile Thr Thr Gly Gly Asp Val Ile Asn Asn Gly Leu Trp Asn 
     370                375                380
Met Val Ser Val Glu Glu Leu Glu His Ser Ile Ser Ile Lys Ile Ala 
 385                390                395                400
Lys Glu Ala Val Met Asp Ile Asn Lys Pro Gly Pro Leu Phe Lys Pro 
                 405                410                415
Glu Asn Gly Leu Leu Glu Thr Lys Val Tyr Phe Ala Gly Phe Pro Arg 
             420                425                430
Lys Val Glu Ser Glu Leu Ile Lys Pro Ile Asn Pro Arg Leu Asp Gly 
         435                440                445
Cys Ile Arg Ser Trp Asn Leu Met Lys Gln Gly Ala Ser Gly Ile Lys 
     450                455                460
Glu Ile Ile Gln Glu Lys Gln Asn Lys His Cys Leu Val Thr Val Glu 
 465                470                475                480
Lys Gly Ser Tyr Tyr Pro Gly Ser Gly Ile Ala Gln Phe His Ile Asp 
                 485                490                495
Tyr Asn Asn Val Ser Ser Ala Glu Gly Trp His Val Asn Val Thr Leu 
             500                505                510
Asn Ile Arg Pro Ser Thr Gly Thr Gly Val Met Leu Ala Leu Val Ser 
         515                520                525
Gly Asn Asn Thr Val Pro Phe Ala Val Ser Leu Val Asp Ser Thr Ser 
     530                535                540
Glu Lys Ser Gln Asp Ile Leu Leu Ser Val Glu Asn Thr Val Ile Tyr 
 545                550                555                560
Arg Ile Gln Ala Leu Ser Leu Cys Ser Asp Gln Gln Ser His Leu Glu 
                 565                570                575
Phe Arg Val Asn Arg Asn Asn Leu Glu Leu Ser Thr Pro Leu Lys Ile 
             580                585                590
Glu Thr Ile Ser His Glu Asp Leu Gln Arg Gln Leu Ala Val Leu Asp 
         595                600                605
Lys Ala Met Lys Ala Lys Val Ala Thr Tyr Leu Gly Gly Leu Pro Asp 
     610                615                620
Val Pro Phe Ser Ala Thr Pro Val Asn Ala Phe Tyr Asn Gly Cys Met 
 625                630                635                640
Glu Val Asn Ile Asn Gly Val Gln Leu Asp Leu Asp Glu Ala Ile Ser 
                 645                650                655
Lys His Asn Asp Ile Arg Ala His Ser Cys Pro Ser Val Trp Lys Lys 
             660                665                670
Thr Lys Asn Ser 
         675



<210> 7995
<211> 2825
<212> DNA
<213> Rattus norvegicus
<308> U06713
<400> 7995

ggatccagg  tttcaagtt  gttagggga  ttaatgcaa  tcaatatgc  aacagagag  60
attgtaaaa  aaaaaatcc  gtcctttct  cggtcacac  caggttagc  aatgtggag  120
tcgcccaga  gctctgcag  accagctca  ggggaaggg  caggaggag  gcagtcccg  180
gggcgggac  atgacgttg  ggtcaaggc  gggcttcct  tcgttcctc  ccgggctgc  240
gccgccgcg  cggtggctc  gcatctcca  aaggggccc  ccgacttct  actgggcca  300
tccggcgct  ggtggcaga  ctctacact  ctcctgccg  tctcagagc  ggactccct  360
ctcttcaga  tttcaagca  ctttccccg  ctttgcagc  aaagtggct  ggggaccgt  420
gctgccgca  gtggtagag  ccccggccc  gctctctgc  tctccgctg  gcgttcgct  480
tgggcaagc  ctcggtgcg  gcaccctgg  ggtcccccg  ctcggctct  tgagcgaga  540
gcctctggg  cacatcatg  ggctggatc  ggagaagat  gccctggag  acatcgtgc  600
ctgtctgca  gaggtcggt  tctgctacc  ggacaactt  ctaggcgag  tggtgggcg  660
ctgcgtact  gagcgagtc  agcagctgc  ttacaacgg  gccctgcgt  acggccagc  720
ggcggggcc  cgcgccggc  tctccaagc  gcacctgcg  ggcgaccag  tcacgtgga  780
cgggggcaa  gaggagggc  gcgaggcca  caacttcct  ctgtccctc  tcgacaggc  840
ggtcctgta  tgcgggagc  gcctgggca  atactatgt  aaggagcgg  ccaaggcga  900
ggtggcttg  tatccagga  atggaacag  ttatgttcg  catgtggac  accccaatg  960
tgatggccg  tgtatcacc  gtatctact  cctgaataa  aattgggac  ccaagttac  1020
tggaggggt  ctgcggata  ttccagaag  aaaatcatt  gtagcagac  tggagccca  1080
ttttgatag  ctcctgttc  cctggtcag  ccgcaggaa  ccacatgaa  ttcagccct  1140
ctatgccac  aggtacgcc  tgactgtct  gtacttcga  gctgaagaa  gggcagaag  1200
caaaaagaa  ttcaggaat  taactagaa  aactgaatc  gctcttgct  aagactgac  1260
gtggtgtga  gtccgctgg  cgcattcgt  tagtgacag  tcctgaaat  ttaagtgtc  1320
agatccaaa  actctgtcc  atcccctgc  taccgcctg  atcgtttgg  tccctacct  1380
gtttgtggt  cttcgtgtt  tcttgctgg  aatgcgttg  cctccagac  ctctctttg  1440
cggatgaac  catttgcta  ctccagaaa  acctgcaga  atcctagct  gccagcggt  1500
taacggata  atctgggaa  ggatagata  gggaatgca  ctgttcagc  caggattgc  1560
tcgtgttcg  actttatgc  tacttcctg  tctgatagg  ggaggtttg  gaagaaata  1620
actggtgac  gatgccaca  agaggcacc  ttgaaaccc  aacagcaag  aagagaaag  1680
tctgaacta  ttccagatg  tgttaaccc  agactggac  attacggac  acctgatga  1740
attatcgcc  ctagaaagg  ctgctgtca  agcgatcga  ttataagtg  cccacggtg  1800
atgctcctt  ttcctggtc  tacaacctg  tctttttga  ggtcattgc  aaattgatg  1860
tctcttgtc  aagacgacc  cagcctgta  gctccattt  tacttctta  ttggggatc  1920
taattatcc  gagaataaa  ctcaccagg  agtttgggt  gttttttct  gtactgaaa  1980
tttgaagtt  aatgagagg  acaggaagc  tcctggtaa  ttagcttct  ctaactctg  2040
gggaagagc  aagcctagc  gtatgcgat  accatgcat  cggtgagca  ttcgagagg  2100
agatgtggt  ggaagtgca  acagccccc  ttcatcatg  tccctttag  tgttcttcg  2160
tcatggcta  gaacagcat  ttgtactct  aaaagatat  gaaataaaa  gacctcaaa  2220
ctatcgagt  ctcccacat  gtctgctct  ccagcctcg  tttagccgt  ttgatcctt  2280
agagcaact  gttggaagt  catccagtg  tgtggaatt  cctagaact  tgggaggtt  2340
ctcctgcag  atgcaggtg  cgcttcccc  agaactctg  acgaaacac  cattttacg  2400
aagttagcc  tcctagttt  cgctgctac  tccccatct  tcgaacctc  ttaatttcc  2460
tgttagaat  ccacaagca  cacagaccc  agagtgttt  atttcatcg  gttcagcca  2520
gcagacttt  caagcaaag  agttgatac  tctttcttc  ttcgggaaa  tgtccagga  2580
gaactgtca  tcctccccc  atggctctg  tttgtttta  ttcccacct  ctaacttac  2640
acgtcattt  cttatttat  atgtttatt  tcttgtagc  tatgatgtc  agagtgtta  2700
acacaacga  ggcagggat  tgtacgttt  tgatccatg  agcatgttc  cagcaccta  2760
gctaacata  agtaagcaa  ggcttacca  acacatgtt  aataaactc  gtctcctct  2820
taaaa  2825



<210> 7996
<211> 356
<212> PRT
<213> Rattus norvegicus
<308> U06713
<400> 7996

Met Thr Leu Arg Ser Arg Arg Gly Phe Leu Ser Phe Leu Pro Gly Leu 
  1               5                  10                  15
Arg Pro Pro Arg Arg Trp Leu Arg Ile Ser Lys Arg Gly Pro Pro Thr 
             20                  25                  30
Ser His Trp Ala Ser Pro Ala Leu Gly Gly Arg Thr Leu His Tyr Ser 
         35                  40                  45
Cys Arg Ser Gln Ser Gly Thr Pro Phe Ser Ser Glu Phe Gln Ala Thr 
     50                  55                  60
Phe Pro Ala Phe Ala Ala Lys Val Ala Arg Gly Pro Trp Leu Pro Gln 
 65                  70                  75                  80
Val Val Glu Pro Pro Ala Arg Leu Ser Ala Ser Pro Leu Cys Val Arg 
                 85                  90                  95
Ser Gly Gln Ala Leu Gly Ala Cys Thr Leu Gly Val Pro Arg Leu Gly 
             100                105                110
Ser Val Ser Glu Met Pro Leu Gly His Ile Met Arg Leu Asp Leu Glu 
         115                120                125
Lys Ile Ala Leu Glu Tyr Ile Val Pro Cys Leu His Glu Val Gly Phe 
     130                135                140
Cys Tyr Leu Asp Asn Phe Leu Gly Glu Val Val Gly Asp Cys Val Leu 
 145                150                155                160
Glu Arg Val Lys Gln Leu His Tyr Asn Gly Ala Leu Arg Asp Gly Gln 
                 165                170                175
Leu Ala Gly Pro Arg Ala Gly Val Ser Lys Arg His Leu Arg Gly Asp 
             180                185                190
Gln Ile Thr Trp Ile Gly Gly Asn Glu Glu Gly Cys Glu Ala Ile Asn 
         195                200                205
Phe Leu Leu Ser Leu Ile Asp Arg Leu Val Leu Tyr Cys Gly Ser Arg 
     210                215                220
Leu Gly Lys Tyr Tyr Val Lys Glu Arg Ser Lys Ala Met Val Ala Cys 
 225                230                235                240
Tyr Pro Gly Asn Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn 
                 245                250                255
Gly Asp Gly Arg Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Lys Asn Trp 
             260                265                270
Asp Ala Lys Leu His Gly Gly Val Leu Arg Ile Phe Pro Glu Gly Lys 
         275                280                285
Ser Phe Val Ala Asp Val Glu Pro Ile Phe Asp Arg Leu Leu Phe Ser 
     290                295                300
Trp Ser Asp Arg Arg Asn Pro His Glu Val Gln Pro Ser Tyr Ala Thr 
 305                310                315                320
Arg Tyr Ala Met Thr Val Trp Tyr Phe Asp Ala Glu Glu Arg Ala Glu 
                 325                330                335
Ala Lys Lys Lys Phe Arg Asn Leu Thr Arg Lys Thr Glu Ser Ala Leu 
             340                345                350
Ala Lys Asp Ter 
         355



<210> 7997
<211> 2770
<212> DNA
<213> Homo sapiens
<308> AK025273
<400> 7997

gagtctggc  gcagtcgcg  cagtggtgg  ttcccatcc  caaaaggcg  cctccgact  60
cttgcgccg  actgctcgc  gggccagtc  ggaaacggg  cgtggagct  cgcaccact  120
ccgctggtt  ccgaaggca  atcccttct  ccgagagtt  cgagaaact  tcccttgtc  180
ccgacgctg  agcggctcg  gtaccgtgg  agccgcagg  ttctgaacc  cgggccacg  240
tccccgcgc  tcggcttcg  gctcgtgta  atcgttccc  ctctggttg  acgctgggg  300
tcccggacc  cgattctgc  ggcgagatg  ccctgggac  catcatgag  ctggacctg  360
agaaaattg  cctggagta  atcgtgccc  gtctgcacg  ggtgggctt  tgctacctg  420
acaacttcc  gggcgaggt  gtgggcgac  gcgtcctgg  gcgcgtcaa  cagctgcac  480
gcaccgggg  cctgcggga  ggccagctg  cggggccgc  cgccggcgt  tccaagcga  540
acctgcggg  cgaccagat  acgtggatc  ggggcaacg  ggagggctg  gaggccatc  600
gcttcctcc  gtccctcat  gacaggctg  tcctctact  cgggagccg  ctgggcaaa  660
actacgtca  ggagaggtc  aaggcaatg  tggcttgct  tccgggaaa  ggaacaggt  720
atgttcgcc  cgtggacaa  cccaacggt  atggtcgct  catcacctg  atctactat  780
tgaacaaga  ttgggatgc  aagctacat  gtgggatcc  gcggatatt  ccagagggg  840
aatcattca  agcagatgt  gagcccatt  ttgacagac  cctgttctt  tggtcagat  900
gtaggaacc  acacgaagt  cagccctct  acgcaacca  atatgctat  actgtctgg  960
actttgatg  tgaagaaag  gcagaagcc  aaaagaaat  caggaattt  actaggaaa  1020
ctgaatctg  cctcactga  gactgaccg  gctctgaaa  ctgctggcc  tgttcattt  1080
agtaacggt  cctgaattc  cttaaattc  ttgagatcc  aagatggcc  cttcagtga  1140
aacaatctc  ctgctactt  ttgcatcct  cacatccct  tcttgtgtg  ggtacttca  1200
gttttcttg  caagactgt  ttgatcttc  gatactctc  ttgccagat  aagttattt  1260
ctaactcca  aaattcctg  agacatcct  ctcggccag  ggtttacct  atagattcg  1320
taatactat  aagagaaga  cctaggagc  cagcgaggg  atgaacctt  cttgcactt  1380
atgtatact  cctgatttg  aaggaggag  tttgaaaag  aaaaaatgg  ggtggtaga  1440
gccacagag  ggcatcacg  aagccttaa  agcaggaaa  agagaaatt  gtgtcatct  1500
aacaatttc  agatgttct  aatccaggg  tgttggggt  tctggagaa  tatcacaac  1560
taatgacat  aatacctct  gaaagggct  ctgtcatag  gaacaattt  taagtgtcc  1620
atggggcag  cactccttt  ttcccagtc  tgcaacctg  attttctgc  tcagctcca  1680
tttgctgaa  ataatgact  tctgaataa  gatggcaac  caatttttt  tccattttc  1740
gttcttacc  gggaaccta  ttccccaga  gctaaaaaa  tagacatta  ttgttttgg  1800
tgctttgtt  gaatggaat  taaatttaa  tgaaaggaa  aatatatcc  tggtagttt  1860
gtgttaacc  ctgataact  tggaaagag  taggtctac  gatatacaa  aaacatgtg  1920
gcatcttga  caatttgag  ggggaggtg  agttggaaa  gtgggtgtt  ctgtttttt  1980
ttttttttt  ttttttttt  agttttcct  tttaatgag  tcacccttt  acacaaaaa  2040
agcagggtg  tgtatttta  aaaaggaag  ggaaataaa  aaatctcaa  gctatttga  2100
ttctcgtct  tccctagca  tctttcttc  gctcacttg  ctctctaga  ccactgtgg  2160
tggcagtat  accagaatc  tggaacttg  tagaactgt  gaagcttct  ctcctgcag  2220
aagcacaga  cgcactgcc  caataactt  gtattgagc  cgtattttg  aaaagctac  2280
tttcctagt  ttcagtatt  ctttcatgt  ttaaaaatc  ctttaattt  ttgcttgaa  2340
atcccatga  cattaaaga  ccagaaata  tttcctttg  tatgtacgg  tatatatat  2400
tatatagtc  tccaagata  aagtttact  tttcctctt  tggttttgg  aaatttcca  2460
ataagacat  tcaccatta  ttctcaacg  ctgctctat  ttgttgtac  gtaatagtt  2520
tcaccttct  aattactat  taatttact  acttattat  tttattgtc  tgtatcctt  2580
ctctggagt  taagcacaa  gaagacagg  attttgtat  tttttaacc  atgcaacat  2640
ctctcagca  ctaaaatag  gccgggaac  tagtaaggg  tcagtaaat  cttgttgaa  2700
aaactcagt  tcctacatt  gcattctaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2760
aaaaaaaaag  2770



<210> 7998
<211> 240
<212> PRT
<213> Homo sapiens
<308> AK025273
<400> 7998

Met Pro Leu Gly His Ile Met Arg Leu Asp Leu Glu Lys Ile Ala Leu 
  1               5                  10                  15
Glu Tyr Ile Val Pro Cys Leu His Glu Val Gly Phe Cys Tyr Leu Asp 
             20                  25                  30
Asn Phe Leu Gly Glu Val Val Gly Asp Cys Val Leu Glu Arg Val Lys 
         35                  40                  45
Gln Leu His Cys Thr Gly Ala Leu Arg Asp Gly Gln Leu Ala Gly Pro 
     50                  55                  60
Arg Ala Gly Val Ser Lys Arg His Leu Arg Gly Asp Gln Ile Thr Trp 
 65                  70                  75                  80
Ile Gly Gly Asn Glu Glu Gly Cys Glu Ala Ile Ser Phe Leu Leu Ser 
                 85                  90                  95
Leu Ile Asp Arg Leu Val Leu Tyr Cys Gly Ser Arg Leu Gly Lys Tyr 
             100                105                110
Tyr Val Lys Glu Arg Ser Lys Ala Met Val Ala Cys Tyr Pro Gly Asn 
         115                120                125
Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp Gly Arg 
     130                135                140
Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Lys Asn Trp Asp Ala Lys Leu 
 145                150                155                160
His Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ser Phe Ile Ala 
                 165                170                175
Asp Val Glu Pro Ile Phe Asp Arg Leu Leu Phe Phe Trp Ser Asp Arg 
             180                185                190
Arg Asn Pro His Glu Val Gln Pro Ser Tyr Ala Thr Arg Tyr Ala Met 
         195                200                205
Thr Val Trp Tyr Phe Asp Ala Glu Glu Arg Ala Glu Ala Lys Lys Lys 
     210                215                220
Phe Arg Asn Leu Thr Arg Lys Thr Glu Ser Ala Leu Thr Glu Asp Ter 
 225                230                235                240



<210> 7999
<211> 2825
<212> DNA
<213> Rattus norvegicus
<308> U06713
<400> 7999

ggatccagg  tttcaagtt  gttagggga  ttaatgcaa  tcaatatgc  aacagagag  60
attgtaaaa  aaaaaatcc  gtcctttct  cggtcacac  caggttagc  aatgtggag  120
tcgcccaga  gctctgcag  accagctca  ggggaaggg  caggaggag  gcagtcccg  180
gggcgggac  atgacgttg  ggtcaaggc  gggcttcct  tcgttcctc  ccgggctgc  240
gccgccgcg  cggtggctc  gcatctcca  aaggggccc  ccgacttct  actgggcca  300
tccggcgct  ggtggcaga  ctctacact  ctcctgccg  tctcagagc  ggactccct  360
ctcttcaga  tttcaagca  ctttccccg  ctttgcagc  aaagtggct  ggggaccgt  420
gctgccgca  gtggtagag  ccccggccc  gctctctgc  tctccgctg  gcgttcgct  480
tgggcaagc  ctcggtgcg  gcaccctgg  ggtcccccg  ctcggctct  tgagcgaga  540
gcctctggg  cacatcatg  ggctggatc  ggagaagat  gccctggag  acatcgtgc  600
ctgtctgca  gaggtcggt  tctgctacc  ggacaactt  ctaggcgag  tggtgggcg  660
ctgcgtact  gagcgagtc  agcagctgc  ttacaacgg  gccctgcgt  acggccagc  720
ggcggggcc  cgcgccggc  tctccaagc  gcacctgcg  ggcgaccag  tcacgtgga  780
cgggggcaa  gaggagggc  gcgaggcca  caacttcct  ctgtccctc  tcgacaggc  840
ggtcctgta  tgcgggagc  gcctgggca  atactatgt  aaggagcgg  ccaaggcga  900
ggtggcttg  tatccagga  atggaacag  ttatgttcg  catgtggac  accccaatg  960
tgatggccg  tgtatcacc  gtatctact  cctgaataa  aattgggac  ccaagttac  1020
tggaggggt  ctgcggata  ttccagaag  aaaatcatt  gtagcagac  tggagccca  1080
ttttgatag  ctcctgttc  cctggtcag  ccgcaggaa  ccacatgaa  ttcagccct  1140
ctatgccac  aggtacgcc  tgactgtct  gtacttcga  gctgaagaa  gggcagaag  1200
caaaaagaa  ttcaggaat  taactagaa  aactgaatc  gctcttgct  aagactgac  1260
gtggtgtga  gtccgctgg  cgcattcgt  tagtgacag  tcctgaaat  ttaagtgtc  1320
agatccaaa  actctgtcc  atcccctgc  taccgcctg  atcgtttgg  tccctacct  1380
gtttgtggt  cttcgtgtt  tcttgctgg  aatgcgttg  cctccagac  ctctctttg  1440
cggatgaac  catttgcta  ctccagaaa  acctgcaga  atcctagct  gccagcggt  1500
taacggata  atctgggaa  ggatagata  gggaatgca  ctgttcagc  caggattgc  1560
tcgtgttcg  actttatgc  tacttcctg  tctgatagg  ggaggtttg  gaagaaata  1620
actggtgac  gatgccaca  agaggcacc  ttgaaaccc  aacagcaag  aagagaaag  1680
tctgaacta  ttccagatg  tgttaaccc  agactggac  attacggac  acctgatga  1740
attatcgcc  ctagaaagg  ctgctgtca  agcgatcga  ttataagtg  cccacggtg  1800
atgctcctt  ttcctggtc  tacaacctg  tctttttga  ggtcattgc  aaattgatg  1860
tctcttgtc  aagacgacc  cagcctgta  gctccattt  tacttctta  ttggggatc  1920
taattatcc  gagaataaa  ctcaccagg  agtttgggt  gttttttct  gtactgaaa  1980
tttgaagtt  aatgagagg  acaggaagc  tcctggtaa  ttagcttct  ctaactctg  2040
gggaagagc  aagcctagc  gtatgcgat  accatgcat  cggtgagca  ttcgagagg  2100
agatgtggt  ggaagtgca  acagccccc  ttcatcatg  tccctttag  tgttcttcg  2160
tcatggcta  gaacagcat  ttgtactct  aaaagatat  gaaataaaa  gacctcaaa  2220
ctatcgagt  ctcccacat  gtctgctct  ccagcctcg  tttagccgt  ttgatcctt  2280
agagcaact  gttggaagt  catccagtg  tgtggaatt  cctagaact  tgggaggtt  2340
ctcctgcag  atgcaggtg  cgcttcccc  agaactctg  acgaaacac  cattttacg  2400
aagttagcc  tcctagttt  cgctgctac  tccccatct  tcgaacctc  ttaatttcc  2460
tgttagaat  ccacaagca  cacagaccc  agagtgttt  atttcatcg  gttcagcca  2520
gcagacttt  caagcaaag  agttgatac  tctttcttc  ttcgggaaa  tgtccagga  2580
gaactgtca  tcctccccc  atggctctg  tttgtttta  ttcccacct  ctaacttac  2640
acgtcattt  cttatttat  atgtttatt  tcttgtagc  tatgatgtc  agagtgtta  2700
acacaacga  ggcagggat  tgtacgttt  tgatccatg  agcatgttc  cagcaccta  2760
gctaacata  agtaagcaa  ggcttacca  acacatgtt  aataaactc  gtctcctct  2820
taaaa  2825



<210> 8000
<211> 356
<212> PRT
<213> Rattus norvegicus
<308> U06713
<400> 8000

Met Thr Leu Arg Ser Arg Arg Gly Phe Leu Ser Phe Leu Pro Gly Leu 
  1               5                  10                  15
Arg Pro Pro Arg Arg Trp Leu Arg Ile Ser Lys Arg Gly Pro Pro Thr 
             20                  25                  30
Ser His Trp Ala Ser Pro Ala Leu Gly Gly Arg Thr Leu His Tyr Ser 
         35                  40                  45
Cys Arg Ser Gln Ser Gly Thr Pro Phe Ser Ser Glu Phe Gln Ala Thr 
     50                  55                  60
Phe Pro Ala Phe Ala Ala Lys Val Ala Arg Gly Pro Trp Leu Pro Gln 
 65                  70                  75                  80
Val Val Glu Pro Pro Ala Arg Leu Ser Ala Ser Pro Leu Cys Val Arg 
                 85                  90                  95
Ser Gly Gln Ala Leu Gly Ala Cys Thr Leu Gly Val Pro Arg Leu Gly 
             100                105                110
Ser Val Ser Glu Met Pro Leu Gly His Ile Met Arg Leu Asp Leu Glu 
         115                120                125
Lys Ile Ala Leu Glu Tyr Ile Val Pro Cys Leu His Glu Val Gly Phe 
     130                135                140
Cys Tyr Leu Asp Asn Phe Leu Gly Glu Val Val Gly Asp Cys Val Leu 
 145                150                155                160
Glu Arg Val Lys Gln Leu His Tyr Asn Gly Ala Leu Arg Asp Gly Gln 
                 165                170                175
Leu Ala Gly Pro Arg Ala Gly Val Ser Lys Arg His Leu Arg Gly Asp 
             180                185                190
Gln Ile Thr Trp Ile Gly Gly Asn Glu Glu Gly Cys Glu Ala Ile Asn 
         195                200                205
Phe Leu Leu Ser Leu Ile Asp Arg Leu Val Leu Tyr Cys Gly Ser Arg 
     210                215                220
Leu Gly Lys Tyr Tyr Val Lys Glu Arg Ser Lys Ala Met Val Ala Cys 
 225                230                235                240
Tyr Pro Gly Asn Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn 
                 245                250                255
Gly Asp Gly Arg Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Lys Asn Trp 
             260                265                270
Asp Ala Lys Leu His Gly Gly Val Leu Arg Ile Phe Pro Glu Gly Lys 
         275                280                285
Ser Phe Val Ala Asp Val Glu Pro Ile Phe Asp Arg Leu Leu Phe Ser 
     290                295                300
Trp Ser Asp Arg Arg Asn Pro His Glu Val Gln Pro Ser Tyr Ala Thr 
 305                310                315                320
Arg Tyr Ala Met Thr Val Trp Tyr Phe Asp Ala Glu Glu Arg Ala Glu 
                 325                330                335
Ala Lys Lys Lys Phe Arg Asn Leu Thr Arg Lys Thr Glu Ser Ala Leu 
             340                345                350
Ala Lys Asp Ter 
         355



<210> 8001
<211> 2770
<212> DNA
<213> Homo sapiens
<308> AK025273
<400> 8001

gagtctggc  gcagtcgcg  cagtggtgg  ttcccatcc  caaaaggcg  cctccgact  60
cttgcgccg  actgctcgc  gggccagtc  ggaaacggg  cgtggagct  cgcaccact  120
ccgctggtt  ccgaaggca  atcccttct  ccgagagtt  cgagaaact  tcccttgtc  180
ccgacgctg  agcggctcg  gtaccgtgg  agccgcagg  ttctgaacc  cgggccacg  240
tccccgcgc  tcggcttcg  gctcgtgta  atcgttccc  ctctggttg  acgctgggg  300
tcccggacc  cgattctgc  ggcgagatg  ccctgggac  catcatgag  ctggacctg  360
agaaaattg  cctggagta  atcgtgccc  gtctgcacg  ggtgggctt  tgctacctg  420
acaacttcc  gggcgaggt  gtgggcgac  gcgtcctgg  gcgcgtcaa  cagctgcac  480
gcaccgggg  cctgcggga  ggccagctg  cggggccgc  cgccggcgt  tccaagcga  540
acctgcggg  cgaccagat  acgtggatc  ggggcaacg  ggagggctg  gaggccatc  600
gcttcctcc  gtccctcat  gacaggctg  tcctctact  cgggagccg  ctgggcaaa  660
actacgtca  ggagaggtc  aaggcaatg  tggcttgct  tccgggaaa  ggaacaggt  720
atgttcgcc  cgtggacaa  cccaacggt  atggtcgct  catcacctg  atctactat  780
tgaacaaga  ttgggatgc  aagctacat  gtgggatcc  gcggatatt  ccagagggg  840
aatcattca  agcagatgt  gagcccatt  ttgacagac  cctgttctt  tggtcagat  900
gtaggaacc  acacgaagt  cagccctct  acgcaacca  atatgctat  actgtctgg  960
actttgatg  tgaagaaag  gcagaagcc  aaaagaaat  caggaattt  actaggaaa  1020
ctgaatctg  cctcactga  gactgaccg  gctctgaaa  ctgctggcc  tgttcattt  1080
agtaacggt  cctgaattc  cttaaattc  ttgagatcc  aagatggcc  cttcagtga  1140
aacaatctc  ctgctactt  ttgcatcct  cacatccct  tcttgtgtg  ggtacttca  1200
gttttcttg  caagactgt  ttgatcttc  gatactctc  ttgccagat  aagttattt  1260
ctaactcca  aaattcctg  agacatcct  ctcggccag  ggtttacct  atagattcg  1320
taatactat  aagagaaga  cctaggagc  cagcgaggg  atgaacctt  cttgcactt  1380
atgtatact  cctgatttg  aaggaggag  tttgaaaag  aaaaaatgg  ggtggtaga  1440
gccacagag  ggcatcacg  aagccttaa  agcaggaaa  agagaaatt  gtgtcatct  1500
aacaatttc  agatgttct  aatccaggg  tgttggggt  tctggagaa  tatcacaac  1560
taatgacat  aatacctct  gaaagggct  ctgtcatag  gaacaattt  taagtgtcc  1620
atggggcag  cactccttt  ttcccagtc  tgcaacctg  attttctgc  tcagctcca  1680
tttgctgaa  ataatgact  tctgaataa  gatggcaac  caatttttt  tccattttc  1740
gttcttacc  gggaaccta  ttccccaga  gctaaaaaa  tagacatta  ttgttttgg  1800
tgctttgtt  gaatggaat  taaatttaa  tgaaaggaa  aatatatcc  tggtagttt  1860
gtgttaacc  ctgataact  tggaaagag  taggtctac  gatatacaa  aaacatgtg  1920
gcatcttga  caatttgag  ggggaggtg  agttggaaa  gtgggtgtt  ctgtttttt  1980
ttttttttt  ttttttttt  agttttcct  tttaatgag  tcacccttt  acacaaaaa  2040
agcagggtg  tgtatttta  aaaaggaag  ggaaataaa  aaatctcaa  gctatttga  2100
ttctcgtct  tccctagca  tctttcttc  gctcacttg  ctctctaga  ccactgtgg  2160
tggcagtat  accagaatc  tggaacttg  tagaactgt  gaagcttct  ctcctgcag  2220
aagcacaga  cgcactgcc  caataactt  gtattgagc  cgtattttg  aaaagctac  2280
tttcctagt  ttcagtatt  ctttcatgt  ttaaaaatc  ctttaattt  ttgcttgaa  2340
atcccatga  cattaaaga  ccagaaata  tttcctttg  tatgtacgg  tatatatat  2400
tatatagtc  tccaagata  aagtttact  tttcctctt  tggttttgg  aaatttcca  2460
ataagacat  tcaccatta  ttctcaacg  ctgctctat  ttgttgtac  gtaatagtt  2520
tcaccttct  aattactat  taatttact  acttattat  tttattgtc  tgtatcctt  2580
ctctggagt  taagcacaa  gaagacagg  attttgtat  tttttaacc  atgcaacat  2640
ctctcagca  ctaaaatag  gccgggaac  tagtaaggg  tcagtaaat  cttgttgaa  2700
aaactcagt  tcctacatt  gcattctaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2760
aaaaaaaaag  2770



<210> 8002
<211> 240
<212> PRT
<213> Homo sapiens
<308> AK025273
<400> 8002

Met Pro Leu Gly His Ile Met Arg Leu Asp Leu Glu Lys Ile Ala Leu 
  1               5                  10                  15
Glu Tyr Ile Val Pro Cys Leu His Glu Val Gly Phe Cys Tyr Leu Asp 
             20                  25                  30
Asn Phe Leu Gly Glu Val Val Gly Asp Cys Val Leu Glu Arg Val Lys 
         35                  40                  45
Gln Leu His Cys Thr Gly Ala Leu Arg Asp Gly Gln Leu Ala Gly Pro 
     50                  55                  60
Arg Ala Gly Val Ser Lys Arg His Leu Arg Gly Asp Gln Ile Thr Trp 
 65                  70                  75                  80
Ile Gly Gly Asn Glu Glu Gly Cys Glu Ala Ile Ser Phe Leu Leu Ser 
                 85                  90                  95
Leu Ile Asp Arg Leu Val Leu Tyr Cys Gly Ser Arg Leu Gly Lys Tyr 
             100                105                110
Tyr Val Lys Glu Arg Ser Lys Ala Met Val Ala Cys Tyr Pro Gly Asn 
         115                120                125
Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp Gly Arg 
     130                135                140
Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Lys Asn Trp Asp Ala Lys Leu 
 145                150                155                160
His Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ser Phe Ile Ala 
                 165                170                175
Asp Val Glu Pro Ile Phe Asp Arg Leu Leu Phe Phe Trp Ser Asp Arg 
             180                185                190
Arg Asn Pro His Glu Val Gln Pro Ser Tyr Ala Thr Arg Tyr Ala Met 
         195                200                205
Thr Val Trp Tyr Phe Asp Ala Glu Glu Arg Ala Glu Ala Lys Lys Lys 
     210                215                220
Phe Arg Asn Leu Thr Arg Lys Thr Glu Ser Ala Leu Thr Glu Asp Ter 
 225                230                235                240



<210> 8003
<211> 5795
<212> DNA
<213> Rattus norvegicus
<308> U06752
<400> 8003

ttaacatct  ctcagagcc  acacactgg  agcatgaag  ccacccaca  tcctcaaac  60
accagaaac  cagaggtga  tacaactct  tctgcctcc  caagtgacc  agttcaggt  120
gagacaact  cccagacaa  actatccga  gcaacaacg  cctcacatg  tcccagaga  180
agcagctca  ctccaagta  atcagatat  ttaaccacc  tggcctcca  agaaggcac  240
tcaggagac  caggacaca  aatggcagt  actactcaa  gttccacac  tgccaccac  300
gagatctca  tgacacctt  aacccagaa  atgtcacct  tgtcaacat  cagcacttc  360
acacaggaa  taacaacac  ttcccaaag  caacacact  gaggcatga  gaccacccg  420
aatcctcaa  ccaccggaa  cacagaggt  actacaact  tttcagcct  ctcaagtga  480
caagttcag  cagagacaa  ttcccagac  acactatct  ctgatacaa  aaccacctc  540
catgctccc  gagagagca  ctcacctcc  agtacttca  acatgttaa  caccacggc  600
tccacagaa  gcacctcag  agacacagg  cacacaacg  cagtaacta  tcagggttc  660
atacctgct  ccacacagt  atcaacaac  ttcgcatct  aaaaaatgt  aacagtgtc  720
acacccacc  cctcctcaa  tcaggaatt  tcaacactt  ctcagagcc  acacactgg  780
agcatggag  tcagtagca  acctcaaac  acctcagtc  catcaactc  ttcatcctc  840
ccaagtggc  caactcctg  acagactcg  tccgtgaca  catcctcag  tgaaagaac  900
aacccaact  cttctggtg  cagtaacac  tccccagct  caacagaag  gctcacccc  960
acatcctct  cagagtcta  tccaggaaa  acagctccg  ggacaactg  gacctctac  1020
acaaccacg  caaaagtct  aatgacatc  ttacaacag  aactaccaa  agggtcaac  1080
ctcggcact  ctacaccca  agaggtgac  acaactctt  cagcctcct  aagtgacca  1140
gttcaggta  agacaactt  ccagacaac  ctatctcct  atgcaacaa  cacctcaca  1200
gctcccaga  agagcagct  acctccaag  acatcagtt  tattaacca  catggcctc  1260
acagaaggc  cctcaggag  cacaggaca  acaacagca  taactgacc  aggttccac  1320
cctgccacc  cagagatct  agtgacacc  tcaacccag  aaatgtcaa  tgtgtcaac  1380
cttgtcact  ctactcaag  attaacttc  tctcagagc  aacgcactg  aagcatggg  1440
accagcagc  aacctcaag  caccacacc  acagaggtg  ccacatcca  tctttcatc  1500
ttttcaagg  gatccttat  ttctgcgcg  aactgctgc  tgcaaacaa  aaaaccacc  1560
ctaccagcg  tggtttgtt  gccggatcc  agctcggta  caagcttga  gcatagcag  1620
aaacctcaa  ccaccacac  gacagaggt  accacatcc  ctctttcat  attttcaag  1680
ggatccact  aaacccaga  agtttcttg  gaaacatcc  cctcaggaa  aataactgc  1740
ccatctact  ccagtagga  gaccccatc  gtagccaca  cagacatat  caccaccac  1800
gactccacc  caggaaacg  ggggcacac  cttttaacg  gaagccaca  tgtgatcac  1860
tcaagagtc  caagcacaa  tctaggccg  ttgtcaact  tagcgcaca  acagtctac  1920
cagcgatca  ctacacatt  tcagagtta  ttgactgaa  gcatggggg  atccagcac  1980
tctgaaacc  gcctcctca  agaggctac  acagagacg  gtttatgcc  cttcacctg  2040
acccactgt  acagagacc  tctctcgtg  acgtcctct  caggattga  cacgaaaac  2100
gacaatgac  gaagtacag  actctcagc  acctccttg  cccttccgg  tcccagcac  2160
tccacagcc  ccaggtcca  agtgcctcc  gcccctctt  caccagatc  gggtatttc  2220
ctctttcag  ttggctttc  cctcggctc  ctctgcggg  ttccttcta  tttacagat  2280
acggtcaga  cattttccc  gagtcagac  acgatgtct  ctcctaccc  aacccacct  2340
aaagaggct  cacaggaag  gagcgtgtg  catagtggc  attctgggg  gatgctgat  2400
tctctagct  caggggaac  atattttag  accactaca  cacatttta  gatgagcag  2460
accagccta  ttcggaagg  ggagtctct  attaatgag  ttacaagtg  ctggagctt  2520
aagccaagt  acactgaag  cacctgggt  aatgttcct  cctatccag  ccaggggag  2580
actttggga  ccaatacct  ccaagccat  ctctccaca  atgggagca  gtcctacgc  2640
ctgtttctc  accagagcg  tggcatgag  tgggatgtg  cccagggac  gtacaaccg  2700
gtgctcatg  gcttctcca  tggagatgg  tattttgaa  acagcccgc  gatattccg  2760
ccagcagtg  agaagtacc  tccagatcg  ttcctaact  caaattacg  atccgggga  2820
tcgaggtct  caggctaca  agggaggtg  ggcccaact  caggctcaa  tgtctgcag  2880
ggttggaaa  tcagcctca  cagcccagc  ggggctgga  caagatttc  tgcccttgc  2940
cctggcagc  gggacttcg  ttctggctc  tcaacacag  tctgtgggg  aggcagcta  3000
gcagcttct  tccgggcag  gcgtgtgct  tacgtatgg  acctgggtg  gtttcgaga  3060
ggctggaga  tgcacagtc  ttggcagtt  gatgaggac  aaggaaggc  cagaactgg  3120
ttggccgct  gaacgacaa  ccctctttc  gcgtccagt  ccagctcag  cggccccga  3180
ttagttgtg  tgggtacca  gcccccccg  cccgcttgg  catttggtg  tccccacat  3240
accactttg  ataacgcca  atacacctt  aacgggcta  gatacttcc  gctggttca  3300
gcccaggac  gaaattctt  cttcctgct  gagggccgc  ctgcccaga  tgattctgc  3360
aatgccacg  acttcattg  ctttgcggc  caatacaac  ccagcagcc  gaagtctcc  3420
atcacagtt  agtggtttc  tgagcccaa  gacacaatc  gagttgtac  caataacca  3480
acggtggcc  ttaacacca  cgacactga  gacttgccc  tattcaatg  cactggtgt  3540
ctactgatc  aaaatggct  ccaagtctc  gccaacttt  atgggacag  gaccatctc  3600
gtgattgct  tctccaaca  ccttcacgc  tcctccagc  tgtcagagg  gtaccgcaa  3660
cacacaaag  gccttctgg  agtctggaa  gacaatcca  aagatgact  cagaatgcc  3720
aatggctcc  ccatcccct  caacacgtc  gaggagact  ttttccact  tggaatgac  3780
tcggaaact  acgggatag  cctccttgg  gtgaggaca  accctctgc  ttctgagtt  3840
actcccatc  tcttgtccc  actgtggaa  aagagcggc  ccggtgaag  cttgatctc  3900
gggtgcaac  aggacgcac  gtgcaagtt  gacatcctg  ccacaggaa  cagagacat  3960
ggacaaagc  ccaactcaa  ccttagaac  ttccggcac  tgaatggca  gctcaacca  4020
tacccaccc  ctatccact  cagcagcaa  attcaagcc  acaaggggc  agaacagtg  4080
ccattgaga  caccagcaa  tctaaggat  tcgtattca  cctctccaa  aagtgcagt  4140
gcctttgag  tctttgaaa  cgggagttt  cacgtggac  ccaacatcc  cagaagaac  4200
tacctggag  ttctagcaa  ggatgtcaa  actaacttg  catcggtac  ccagcctga  4260
acggtggct  gcttctgta  taaggagga  cagtgtttg  acaacgaga  cagcaaaga  4320
ggcaactct  ccactgagg  gaccagctg  aagtgcgat  ggaactcct  cggccgctt  4380
tgtgaacac  ctaaggacc  ctgcactga  ccatgcttc  ctaatgtgg  ctgcattcc  4440
gggaagggc  gtcaggcct  ccctccaaa  atgactgga  atgggcgtc  ttgtgtagc  4500
gtggagatc  ctgaattct  ccagaacca  tcctgtcct  tgaattact  ctataacca  4560
ggccattgc  acatctctg  gcctccaga  tgccagccc  cttgcacct  cgcccctgc  4620
ttcactggt  accgctgct  cctggccgg  aacaatttc  ctcccatca  ctataaaga  4680
cttcccttg  ggaccatca  gctctctct  agggaggac  aaaacgcct  taacgctga  4740
gtcaatgcc  cggtggcaa  cgtactaga  aacttggac  tgcgggctt  tctctccaa  4800
agcttagtg  agctgatac  aacctctcc  ggagcacca  tccttggca  gcccattca  4860
cactggaag  tcgtctccc  cttcaagta  cgtcccagg  gacccctca  ccactatct  4920
aacaaccaa  tgataagcg  cgtgatgga  gccttcctc  tccaggctc  gcaggagag  4980
cggaagagg  gtggagaag  caggaagaa  gtccgcttc  tccccatct  gagggcaga  5040
gtccaggac  ggatggccc  gaacctaag  atgctggac  agtacttca  gtgcgatgg  5100
tacaaaggc  accacttgg  ctacagccc  caggatggc  tcacctgtg  gtccccatg  5160
agtgagggc  actgtcaca  tggaggcca  tgcaagcac  tgccagatg  gccccagtg  5220
acgtgcgca  ccttcagca  ctacacatc  tggggcgaa  gctgtgagc  tctaagcgt  5280
aaacttggg  cattcttcg  gatcctctt  ggagccctg  gtgccctct  gctactggc  5340
atcttagca  gtgtggtct  tcacttctg  ggctgctcc  tgaacaagt  ctcctaccc  5400
ctggactca  aactgtgag  cctcgtccc  gatgggcag  tgcacctag  atacctcag  5460
acccgccca  cggtctgcc  ctgctctag  gagactgga  agggccgac  cgatgaaga  5520
gatttgaga  tcttcaagc  tgaataaag  gagtgaaac  agactctac  attttagta  5580
gccatgggt  taggttttc  ggagatgag  aaatgtaga  atggatgga  tcctataca  5640
cacatggga  aggatattg  ctatgtaca  acacacaca  acacacacc  gagttaatg  5700
atgactggc  ttatattca  caaaatgtt  ttacttata  aaccagcat  cttctcatt  5760
aaatctatt  aaatataaa  aaaaaaccg  aattc  5795



<210> 8004
<211> 1805
<212> PRT
<213> Rattus norvegicus
<308> AAA85523
<400> 8004

Leu Thr Ser Ser Gln Ser Gln His Thr Gly Ser Met Lys Thr Thr His 
  1               5                  10                  15
Asn Pro Gln Thr Thr Arg Asn Thr Glu Val Thr Thr Thr Leu Ser Ala 
             20                  25                  30
Ser Ser Ser Asp Gln Val Gln Val Glu Thr Thr Ser Gln Thr Thr Leu 
         35                  40                  45
Ser Asp Ala Thr Thr Thr Ser His Ala Pro Arg Glu Ser Ser Ser Pro 
     50                  55                  60
Pro Ser Thr Ser Asp Ile Leu Thr Thr Met Ala Ser Thr Glu Gly Thr 
 65                  70                  75                  80
Ser Gly Asp Thr Gly His Thr Met Ala Val Thr Thr Gln Gly Ser Thr 
                 85                  90                  95
Pro Ala Thr Thr Glu Ile Ser Val Thr Pro Ser Thr Gln Lys Met Ser 
             100                105                110
Pro Val Ser Thr Phe Ser Thr Ser Thr Gln Glu Ile Thr Thr Leu Ser 
         115                120                125
Gln Ser Gln His Thr Gly Gly Met Lys Thr Thr Arg Asn Pro Gln Thr 
     130                135                140
Thr Gly Thr Thr Glu Val Thr Thr Thr Leu Ser Ala Ser Ser Ser Asp 
 145                150                155                160
Gln Val Gln Ala Glu Thr Ser Ser Gln Thr Thr Leu Ser Pro Asp Thr 
                 165                170                175
Thr Thr Thr Ser His Ala Pro Arg Glu Ser Ser Ser Pro Pro Ser Thr 
             180                185                190
Ser Asp Met Leu Thr Thr Thr Ala Ser Thr Glu Gly Thr Ser Gly Asp 
         195                200                205
Thr Gly His Thr Thr Ala Val Thr Thr Gln Gly Ser Ile Pro Ala Thr 
     210                215                220
Thr Gln Leu Ser Thr Thr Phe Ala Ser Gln Lys Met Ser Thr Val Ser 
 225                230                235                240
Thr Pro Thr Thr Ser Ser Ile Gln Glu Leu Ser Thr Leu Pro Gln Ser 
                 245                250                255
Gln His Thr Gly Ser Met Glu Ile Ser Ser Arg Pro Gln Thr Thr Ser 
             260                265                270
Val Thr Ser Thr Leu Ser Ser Ser Pro Ser Gly Ser Thr Pro Val Gln 
         275                280                285
Thr Arg Ser Val Thr Ser Ser Ser Asp Glu Arg Thr Asn Pro Thr Ser 
     290                295                300
Ser Gly Val Ser Asn Thr Ser Pro Ala Thr Thr Glu Val Leu Thr Pro 
 305                310                315                320
Thr Ser Ser Pro Glu Ser Thr Pro Gly Asn Thr Ala Pro Arg Thr Thr 
                 325                330                335
Glu Thr Ser Thr Thr Thr Thr Thr Lys Val Leu Met Thr Ser Leu Gln 
             340                345                350
Gln Lys Leu Pro Thr Gly Ser Thr Leu Gly Thr Ser Thr Pro Thr Glu 
         355                360                365
Val Thr Thr Thr Leu Ser Ala Ser Ser Ser Asp Gln Val Gln Val Glu 
     370                375                380
Thr Thr Ser Gln Thr Thr Leu Ser Pro Asp Ala Thr Thr Thr Ser His 
 385                390                395                400
Ala Pro Arg Glu Ser Ser Ser Pro Pro Ser Thr Ser Val Ile Leu Thr 
                 405                410                415
Thr Met Ala Ser Thr Glu Gly Thr Ser Gly Asp Thr Gly His Thr Thr 
             420                425                430
Ala Val Thr Asp Gln Gly Ser Thr Pro Ala Thr Thr Glu Ile Ser Val 
         435                440                445
Thr Pro Ser Thr Gln Lys Met Ser Thr Val Ser Thr Leu Val Thr Ser 
     450                455                460
Thr Gln Glu Leu Thr Ser Ser Gln Ser Gln Arg Thr Gly Ser Met Gly 
 465                470                475                480
Thr Ser Ser Lys Pro Gln Ala Thr Thr Pro Thr Glu Val Thr Thr Ser 
                 485                490                495
Thr Leu Ser Ser Phe Ser Arg Gly Ser Leu Phe Ser Ala Arg Asn Cys 
             500                505                510
Cys Leu Gln Thr Lys Lys Pro Pro Leu Pro Ala Val Val Cys Leu Pro 
         515                520                525
Asp Pro Ser Ser Val Pro Ser Leu Met His Ser Ser Lys Pro Gln Ala 
     530                535                540
Thr Thr Pro Thr Glu Val Thr Thr Ser Thr Leu Ser Ser Phe Ser Arg 
 545                550                555                560
Gly Ser Thr Gln Thr Gln Thr Val Ser Trp Glu Thr Ser Ser Ser Gly 
                 565                570                575
Lys Ile Thr Ala Pro Ser Thr Ser Ser Arg Arg Thr Pro Ser Val Ala 
             580                585                590
Thr Ser Asp Ile Phe Thr Thr Thr Asp Ser Thr Ser Gly Asn Ala Gly 
         595                600                605
His Thr Leu Leu Thr Gly Ser His Ser Val Ile Thr Ser Arg Val Ala 
     610                615                620
Ser Thr Thr Leu Gly Arg Leu Ser Thr Val Ala His Arg Gln Ser Thr 
 625                630                635                640
Gln Arg Ser Ser Thr His Ser Gln Ser Tyr Leu Thr Glu Ser Met Gly 
                 645                650                655
Ala Ser Ser Thr Ser Glu Thr Ser Leu Leu Thr Glu Ala Thr Thr Glu 
             660                665                670
Thr Ser Leu Cys Leu Phe Thr Trp Thr His Cys Asp Arg Asp Leu Leu 
         675                680                685
Ser Trp Thr Ser Ser Ser Gly Leu Thr Thr Lys Thr Asp Asn Asp Arg 
     690                695                700
Ser Thr Ala Leu Ser Ala Thr Ser Leu Thr Leu Pro Ala Pro Ser Thr 
 705                710                715                720
Ser Thr Ala Ser Arg Ser Thr Val Pro Pro Ala Pro Leu Pro Pro Asp 
                 725                730                735
Gln Gly Ile Ser Leu Phe Gln Ile Gly Phe Pro Leu Gly Ser Leu Cys 
             740                745                750
Gly Ile Pro Ser Ile Leu Gln Ile Thr Val Arg Ser Phe Ser Pro Ser 
         755                760                765
Gln Thr Thr Met Ser Ser Pro Thr Pro Thr His Leu Lys Glu Ala Ser 
     770                775                780
Gln Glu Gly Ser Val Cys His Ser Gly His Ser Gly Val Met Leu Ile 
 785                790                795                800
Ser Leu Ala Pro Gly Glu Pro Tyr Phe Arg Thr Thr Thr Ser His Phe 
                 805                810                815
Thr Met Ser Ser Thr Ser Leu Ile Arg Lys Val Glu Ser Leu Ile Asn 
             820                825                830
Glu Phe Thr Ser Asp Trp Ser Phe Lys Pro Ser Asp Thr Glu Val Thr 
         835                840                845
Trp Val Asn Val Pro Ala Tyr Pro Ala Gln Gly Arg Thr Leu Gly Ala 
     850                855                860
Asn Thr Tyr Gln Ala Ile Leu Ser Thr Asp Gly Ser Arg Ser Tyr Ala 
 865                870                875                880
Leu Phe Leu Tyr Gln Ser Gly Gly Met Arg Trp Asp Val Thr Gln Gly 
                 885                890                895
Leu Tyr Asn Arg Val Leu Met Gly Phe Ser Ser Gly Asp Gly Tyr Phe 
             900                905                910
Glu Asn Ser Pro Leu Ile Phe Arg Pro Ala Val Glu Lys Tyr Arg Pro 
         915                920                925
Asp Arg Phe Leu Thr Pro Asn Tyr Gly Ser Gly Asp Ser Arg Ser Thr 
     930                935                940
Gly Tyr Thr Gly Arg Cys Gly Pro Thr Thr Gly Ser Ser Val Cys Ser 
 945                950                955                960
Gly Trp Lys Val Ser Leu Ser Ser Pro Ala Gly Ala Gly Thr Arg Phe 
                 965                970                975
Pro Ala Leu Ala Pro Gly Ser Arg Asp Phe Gly Ser Gly Ser Ser Thr 
             980                985                990
Gln Val Cys Gly Ala Gly Ser Tyr Ala Ala Ser Leu Arg Ala Gly Arg 
         995                1000                1005
Val Leu Tyr Val Trp His Leu Gly Glu Phe Arg Glu Gly Trp Arg Met 
     1010                1015                1020
His Ser Pro Trp Gln Phe Asp Glu Asp Glu Gly Arg His Arg Thr Gly 
 1025                1030                1035                1040
Leu Ala Ala Gly Thr Thr Ser Pro Leu Ser Ala Ser Ser Thr Ser Ser 
                 1045                1050                1055
Gly Gly Pro Glu Leu Val Val Leu Gly Thr Arg Pro Pro Arg Pro Ala 
             1060                1065                1070
Trp Thr Phe Gly Asp Pro His Ile Thr Thr Leu Asp Asn Ala Lys Tyr 
         1075                1080                1085
Thr Phe Asn Gly Leu Gly Tyr Phe Leu Leu Val Gln Ala Gln Asp Arg 
     1090                1095                1100
Asn Ser Ser Phe Leu Leu Glu Gly Arg Thr Ala Gln Thr Asp Ser Ala 
 1105                1110                1115                1120
Asn Ala Thr Asn Phe Ile Ala Phe Ala Ala Gln Tyr Asn Thr Ser Ser 
                 1125                1130                1135
Leu Lys Ser Pro Ile Thr Val Gln Trp Phe Leu Glu Pro Asn Asp Thr 
             1140                1145                1150
Ile Arg Val Val His Asn Asn Gln Thr Val Ala Phe Asn Thr Ser Asp 
         1155                1160                1165
Thr Glu Asp Leu Pro Val Phe Asn Ala Thr Gly Val Leu Leu Ile Gln 
     1170                1175                1180
Asn Gly Ser Gln Val Ser Ala Asn Phe Asp Gly Thr Val Thr Ile Ser 
 1185                1190                1195                1200
Val Ile Ala Leu Ser Asn Ile Leu His Ala Ser Ser Ser Leu Ser Glu 
                 1205                1210                1215
Glu Tyr Arg Asn His Thr Lys Gly Leu Leu Gly Val Trp Asn Asp Asn 
             1220                1225                1230
Pro Glu Asp Asp Phe Arg Met Pro Asn Gly Ser Thr Ile Pro Ser Asn 
         1235                1240                1245
Thr Ser Glu Glu Thr Leu Phe His Tyr Gly Met Thr Ser Glu Thr Asn 
     1250                1255                1260
Gly Ile Gly Leu Leu Gly Val Arg Thr Asp Pro Leu Pro Ser Glu Phe 
 1265                1270                1275                1280
Thr Pro Ile Phe Leu Ser Gln Leu Trp Asn Lys Ser Gly Ala Gly Glu 
                 1285                1290                1295
Asp Leu Ile Ser Gly Cys Asn Glu Asp Ala Gln Cys Lys Phe Asp Ile 
             1300                1305                1310
Leu Ala Thr Gly Asn Arg Asp Ile Gly Gln Ser Thr Asn Ser Ile Leu 
         1315                1320                1325
Arg Thr Phe Arg His Val Asn Gly Thr Leu Asn Gln Tyr Pro Pro Pro 
     1330                1335                1340
Ile His Tyr Ser Ser Lys Ile Gln Ala Tyr Lys Gly Arg Glu Gln Trp 
 1345                1350                1355                1360
Pro Leu Arg Ser Pro Ala Thr Leu Arg Met Ser Tyr Ser Ala Ser Pro 
                 1365                1370                1375
Thr Ser Ala Val Ala Phe Glu Leu Phe Glu Asn Gly Ser Leu His Val 
             1380                1385                1390
Asp Thr Asn Ile Pro Arg Arg Thr Tyr Leu Glu Ile Leu Ala Arg Asp 
         1395                1400                1405
Val Lys Thr Asn Leu Ser Ser Val Leu Gln Pro Glu Thr Val Ala Cys 
     1410                1415                1420
Phe Cys Ser Lys Glu Glu Gln Cys Leu Tyr Asn Glu Thr Ser Lys Glu 
 1425                1430                1435                1440
Gly Asn Ser Ser Thr Glu Val Thr Ser Cys Lys Cys Asp Gly Asn Ser 
                 1445                1450                1455
Phe Gly Arg Leu Cys Glu His Ser Lys Asp Leu Cys Thr Glu Pro Cys 
             1460                1465                1470
Phe Pro Asn Val Asp Cys Ile Pro Gly Lys Gly Cys Gln Ala Cys Pro 
         1475                1480                1485
Pro Asn Met Thr Gly Asp Gly Arg His Cys Val Ala Val Glu Ile Ser 
     1490                1495                1500
Glu Phe Cys Gln Asn His Ser Cys Pro Val Asn Tyr Cys Tyr Asn His 
 1505                1510                1515                1520
Gly His Cys Asp Ile Ser Gly Pro Pro Asp Cys Gln Pro Thr Cys Thr 
                 1525                1530                1535
Cys Ala Pro Ala Phe Thr Gly Asn Arg Cys Phe Leu Ala Gly Asn Asn 
             1540                1545                1550
Phe Thr Pro Ile Ile Tyr Lys Glu Leu Pro Leu Arg Thr Ile Thr Leu 
         1555                1560                1565
Ser Leu Arg Glu Asp Glu Asn Ala Ser Asn Ala Asp Val Asn Ala Ser 
     1570                1575                1580
Val Ala Asn Val Leu Glu Asn Leu Asp Met Arg Ala Phe Leu Ser Asn 
 1585                1590                1595                1600
Ser Leu Val Glu Leu Ile Arg Thr Ser Pro Gly Ala Pro Val Leu Gly 
                 1605                1610                1615
Lys Pro Ile His His Trp Lys Val Val Ser His Phe Lys Tyr Arg Pro 
             1620                1625                1630
Arg Gly Pro Leu Ile His Tyr Leu Asn Asn Gln Leu Ile Ser Ala Val 
         1635                1640                1645
Met Glu Ala Phe Leu Leu Gln Ala Arg Gln Glu Arg Arg Lys Arg Ser 
     1650                1655                1660
Gly Glu Ala Arg Lys Asn Val Arg Phe Phe Pro Ile Ser Arg Ala Asp 
 1665                1670                1675                1680
Val Gln Asp Gly Met Ala Leu Asn Leu Ser Met Leu Asp Glu Tyr Phe 
                 1685                1690                1695
Thr Cys Asp Gly Tyr Lys Gly Tyr His Leu Val Tyr Ser Pro Gln Asp 
             1700                1705                1710
Gly Val Thr Cys Val Ser Pro Cys Ser Glu Gly Tyr Cys His Asn Gly 
         1715                1720                1725
Gly Gln Cys Lys His Leu Pro Asp Gly Pro Gln Cys Thr Cys Ala Thr 
     1730                1735                1740
Phe Ser Ile Tyr Thr Ser Trp Gly Glu Arg Cys Glu His Leu Ser Val 
 1745                1750                1755                1760
Lys Leu Gly Ala Phe Phe Gly Ile Leu Phe Gly Ala Leu Gly Ala Leu 
                 1765                1770                1775
Leu Leu Leu Ala Ile Leu Ala Cys Val Val Phe His Phe Cys Gly Cys 
             1780                1785                1790
Ser Met Asn Lys Phe Ser Tyr Pro Leu Asp Ser Glu Leu 
         1795                1800                1805



<210> 8005
<211> 3815
<212> DNA
<213> Homo sapiens
<308> AJ242542
<400> 8005

cctctgaag  tggaaacat  aggaatgac  acaccgtca  tgaagacag  cggtgggag  60
cgcacagcc  catcaccac  ccccacaac  tcccagacc  tcatttcca  cattcccag  120
actgccatg  acacccgct  cacagctgc  cccatcccc  tcctgcctg  gagaggtga  180
gccatacag  agtttccct  ttcccctat  gggcagacg  cggggacct  gagttcgtc  240
ggaggaccg  ggacttcac  tccccactc  tcaagccgg  gactggctt  ccccttggc  300
cctctctcc  tgattccct  tacttcaca  acaatggcc  gatcatctt  ccagagtca  360
actaccaga  tttctccta  cccaaccca  tcccaacag  cttcacagg  cgggaccct  420
tggccctgg  ggctccgtt  tgggacgat  ctgacttct  cactggtcg  gggaccaca  480
tttatcagg  atacgagac  ttctatggt  aacacagcc  gctagtcca  caggccgag  540
cttggatta  aaagatcac  aacaacggg  gctacaagg  caggtgggc  ctaaaggtc  600
cgtgggtca  tgcccacgc  tatcctgcc  agtggaccc  cgggagcaa  acctaccaa  660
ccatcctct  cacggacgg  agcaggtcc  atgccctgt  tctctacca  agcggtggg  720
tgcagtggg  cgtggccca  cgctcaggc  acccggtgc  catgggctt  tctaggcct  780
caagggctg  agttctaca  gctacaccg  gaagaaagg  ccaactacc  tctcgagtg  840
ctgcagtgg  tgaagagcc  gcctcggtg  cccagctgg  gctggaacc  ggtctcctg  900
ccttgttcc  ggcagcagg  acgacggga  ttacgattc  aacccgtca  cataggtcg  960
tggggcctc  gcagtaggc  gctgtgcag  ttcacctct  ggcgaggag  cgtgtgctg  1020
agctacggg  cctggggag  gtttcgtga  ggctggcac  tgcagcgtc  ttggcagtt  1080
gcccaggaa  tggagccac  gagctggtg  tgccgctgg  atgacaagc  ctacctctg  1140
gccctgtac  agcagaggc  gccccacgt  ggctgtgct  catacaggc  cccacagcc  1200
gcctggatg  tcggggacc  ccacatcac  accttggat  gtgtcagtt  caccttcaa  1260
gggctgggg  acttcctgc  ggtcggggc  caagacggg  actcctcct  cctgcttca  1320
ggccgcacc  cccagactg  ctcagccca  gccaccaac  tcatcgcct  tgcggctca  1380
taccgctcc  gcagcctgg  ccccgtcac  gtccaatgg  tccttgagc  tcacgacgc  1440
atccgtgtc  tgctggata  ccagactgt  acatttcag  ctgaccatg  agacggcgg  1500
ggccaggag  cgttcaacg  caccggagt  ctcctgagc  gcaacggct  tgaggtctc  1560
gccagcttc  acggctggg  caccgtctc  gtgatcgcg  tctccaaca  cctccacgc  1620
tccgccagc  tcccgcccg  gtaccagaa  cgcacggag  ggctcctgg  ggtctggaa  1680
aacaatcca  aggacgact  caggatgcc  aatggctcc  ccattcccc  agggagccc  1740
gaggagatg  ttttccact  tggaatgac  tggcagatc  acgggacag  cctccttgg  1800
aagaggaat  accagctgc  ttccaactt  acccctgtt  tctactcac  actgcaaaa  1860
aacagctcc  gggctgaac  tttgatctc  aactgtgac  gagatagct  atgcatcta  1920
gacaccctg  ccctgcgca  cgcaagcat  ggacttcac  cgagggaag  cagtaaaaa  1980
tacgagcag  cgaacgcca  cctcaatca  tacccgccc  ccatcaatg  tggtcgtgt  2040
attgaagcc  acaaggggc  gaccacgct  attcagtac  ccagcaatg  tgaggatgc  2100
aacttcacg  tcagagaca  ctgcaccga  ttggagctc  ttgagaatg  gacgttgct  2160
tggacaccc  agtcgctgg  gccattcac  ctggagatt  tagcaagaa  tgccaagat  2220
ggcttggca  ctgcactcc  gcccaggac  gtggtctgc  attgcaatg  agagagcca  2280
tgtttgtac  atcagacca  cagggtggg  aactcctcc  tggaggtgg  tggctgcaa  2340
tgtgacggg  gcaccttcg  ccgctactg  gagggctcc  aggatgcct  tgaggagcc  2400
tgcttcccg  gtgtccact  cgttcctgg  aagggctgc  aggcctgcc  tccaaacct  2460
actggggat  ggcggcact  tgcggctct  gggagctct  tcctgtgtc  gaaccagtc  2520
tgccctgtg  attactgct  caatcaagg  cactgctac  tctcccaga  tctgggctg  2580
cagcccatg  gcacctgcc  cccagcctt  actgacagc  gctgcttcc  ggctgggaa  2640
aacttcagt  caactgtca  cctagaact  cccttaaga  tcatccagc  cttgctcag  2700
gaagaggaa  atgcctcca  ggcagaggt  aacgcctcg  tggcataca  actggggac  2760
ctggacatg  gggcctttc  ccgcaacag  caagtggaa  gaatcgatt  tgcagcacc  2820
gcctcggga  gccccatcc  acactggat  gtcatctcg  agttccagt  ccgccctcg  2880
ggcccggtc  ttgacttcc  gaacaacca  ctgctggcc  cggtggtgg  ggcgttctt  2940
taccacgtt  cacggagga  tgaggagcc  aggaacgac  tggtcttcc  gcccatctc  3000
gaggaagac  tgcgcgatg  gacagccct  aacgtgagc  cgctgaagg  ttacttcag  3060
tgcgatggc  acaagggct  cgacctggt  tacagcccc  agagcggct  cacctgcgt  3120
tccccgtgc  gtaggggct  ctgtgacca  ggaggccag  gccaacacc  gcccagtgg  3180
ccccgctgc  gctgtgtgt  cttctccat  tacacggcc  ggggcgagc  ctgtgagca  3240
ctgagcatg  aactcgacg  gttcttcgg  atcttcttt  gggccctgg  cggcctctt  3300
ctgctgggg  tcgggacgt  cgtggtcct  cgcttctgg  gttgctccg  ggccaggtt  3360
tcctatttc  tgaactcag  tgaggcctt  ccttgaagg  gcagctgtg  cctaggcta  3420
ctcaagact  acctcatcc  taccgcaca  ttaaggcgc  attgctttt  ggagactgg  3480
aaagggaag  tgactgaag  ctgtcagga  tcttcaagg  gaatgaata  tgggaatca  3540
gacaggact  taccttatc  ataggcgca  gtgcacagg  ggaggccat  aagatcaaa  3600
atgcatgga  gggtcctca  gcagacaca  ccacagaag  acactagcc  ggcgcgcgt  3660
cacacacac  cacacacac  cgagttcat  atgtggtga  ggccctaag  taagcaaaa  3720
gcttctgca  acaaaactc  ctggtttac  tcaaattaa  tctatttaa  taaagtctc  3780
ctgactttt  gtgtctcca  aaaaaaaaa  aaaaa  3815



<210> 8006
<211> 1125
<212> PRT
<213> Homo sapiens
<308> CAB85606
<400> 8006

Met Lys Gly Ala Arg Trp Arg Arg Val Pro Trp Val Ser Leu Ser Cys 
  1               5                  10                  15
Leu Cys Leu Cys Leu Leu Pro His Val Val Pro Gly Val Ser Leu Phe 
             20                  25                  30
Pro Tyr Gly Ala Asp Ala Gly Asp Leu Glu Phe Val Arg Arg Thr Val 
         35                  40                  45
Asp Phe Thr Ser Pro Leu Phe Lys Pro Ala Thr Gly Phe Pro Leu Gly 
     50                  55                  60
Ser Ser Leu Arg Asp Ser Leu Tyr Phe Thr Asp Asn Gly Gln Ile Ile 
 65                  70                  75                  80
Phe Pro Glu Ser Asp Tyr Gln Ile Phe Ser Tyr Pro Asn Pro Leu Pro 
                 85                  90                  95
Thr Gly Phe Thr Gly Arg Asp Pro Val Ala Leu Val Ala Pro Phe Trp 
             100                105                110
Asp Asp Ala Asp Phe Ser Thr Gly Arg Gly Thr Thr Phe Tyr Gln Glu 
         115                120                125
Tyr Glu Thr Phe Tyr Gly Glu His Ser Leu Leu Val Gln Gln Ala Glu 
     130                135                140
Ser Trp Ile Arg Lys Ile Thr Asn Asn Gly Gly Tyr Lys Ala Arg Trp 
 145                150                155                160
Ala Leu Lys Val Thr Trp Val Asn Ala His Ala Tyr Pro Ala Gln Trp 
                 165                170                175
Thr Leu Gly Ser Asn Thr Tyr Gln Ala Ile Leu Ser Thr Asp Gly Ser 
             180                185                190
Arg Ser Tyr Ala Leu Phe Leu Tyr Gln Ser Gly Gly Met Gln Trp Asp 
         195                200                205
Val Ala Gln Arg Ser Gly Asn Pro Val Leu Met Gly Phe Ser Ser Gly 
     210                215                220
Asp Gly Tyr Phe Glu Asn Ser Pro Leu Met Ser Gln Pro Val Trp Glu 
 225                230                235                240
Arg Tyr Arg Pro Asp Arg Phe Leu Asn Ser Asn Ser Gly Leu Gln Gly 
                 245                250                255
Leu Gln Phe Tyr Arg Leu His Arg Glu Glu Arg Pro Asn Tyr Arg Leu 
             260                265                270
Glu Cys Leu Gln Trp Leu Lys Ser Gln Pro Arg Trp Pro Ser Trp Gly 
         275                280                285
Trp Asn Gln Val Ser Cys Pro Cys Ser Trp Gln Gln Gly Arg Arg Asp 
     290                295                300
Leu Arg Phe Gln Pro Val Ser Ile Gly Arg Trp Gly Leu Gly Ser Arg 
 305                310                315                320
Gln Leu Cys Ser Phe Thr Ser Trp Arg Gly Gly Val Cys Cys Ser Tyr 
                 325                330                335
Gly Pro Trp Gly Glu Phe Arg Glu Gly Trp His Val Gln Arg Pro Trp 
             340                345                350
Gln Leu Ala Gln Glu Leu Glu Pro Gln Ser Trp Cys Cys Arg Trp Asn 
         355                360                365
Asp Lys Pro Tyr Leu Cys Ala Leu Tyr Gln Gln Arg Arg Pro His Val 
     370                375                380
Gly Cys Ala Thr Tyr Arg Pro Pro Gln Pro Ala Trp Met Phe Gly Asp 
 385                390                395                400
Pro His Ile Thr Thr Leu Asp Gly Val Ser Tyr Thr Phe Asn Gly Leu 
                 405                410                415
Gly Asp Phe Leu Leu Val Gly Ala Gln Asp Gly Asn Ser Ser Phe Leu 
             420                425                430
Leu Gln Gly Arg Thr Ala Gln Thr Gly Ser Ala Gln Ala Thr Asn Phe 
         435                440                445
Ile Ala Phe Ala Ala Gln Tyr Arg Ser Ser Ser Leu Gly Pro Val Thr 
     450                455                460
Val Gln Trp Leu Leu Glu Pro His Asp Ala Ile Arg Val Leu Leu Asp 
 465                470                475                480
Asn Gln Thr Val Thr Phe Gln Pro Asp His Glu Asp Gly Gly Gly Gln 
                 485                490                495
Glu Thr Phe Asn Ala Thr Gly Val Leu Leu Ser Arg Asn Gly Ser Glu 
             500                505                510
Val Ser Ala Ser Phe Asp Gly Trp Ala Thr Val Ser Val Ile Ala Leu 
         515                520                525
Ser Asn Ile Leu His Ala Ser Ala Ser Leu Pro Pro Glu Tyr Gln Asn 
     530                535                540
Arg Thr Glu Gly Leu Leu Gly Val Trp Asn Asn Asn Pro Glu Asp Asp 
 545                550                555                560
Phe Arg Met Pro Asn Gly Ser Thr Ile Pro Pro Gly Ser Pro Glu Glu 
                 565                570                575
Met Leu Phe His Phe Gly Met Thr Trp Gln Ile Asn Gly Thr Gly Leu 
             580                585                590
Leu Gly Lys Arg Asn Asp Gln Leu Pro Ser Asn Phe Thr Pro Val Phe 
         595                600                605
Tyr Ser Gln Leu Gln Lys Asn Ser Ser Trp Ala Glu His Leu Ile Ser 
     610                615                620
Asn Cys Asp Gly Asp Ser Ser Cys Ile Tyr Asp Thr Leu Ala Leu Arg 
 625                630                635                640
Asn Ala Ser Ile Gly Leu His Thr Arg Glu Val Ser Lys Asn Tyr Glu 
                 645                650                655
Gln Ala Asn Ala Thr Leu Asn Gln Tyr Pro Pro Ser Ile Asn Gly Gly 
             660                665                670
Arg Val Ile Glu Ala Tyr Lys Gly Gln Thr Thr Leu Ile Gln Tyr Thr 
         675                680                685
Ser Asn Ala Glu Asp Ala Asn Phe Thr Leu Arg Asp Ser Cys Thr Asp 
     690                695                700
Leu Glu Leu Phe Glu Asn Gly Thr Leu Leu Trp Thr Pro Lys Ser Leu 
 705                710                715                720
Glu Pro Phe Thr Leu Glu Ile Leu Ala Arg Ser Ala Lys Ile Gly Leu 
                 725                730                735
Ala Ser Ala Leu Gln Pro Arg Thr Val Val Cys His Cys Asn Ala Glu 
             740                745                750
Ser Gln Cys Leu Tyr Asn Gln Thr Ser Arg Val Gly Asn Ser Ser Leu 
         755                760                765
Glu Val Ala Gly Cys Lys Cys Asp Gly Gly Thr Phe Gly Arg Tyr Cys 
     770                775                780
Glu Gly Ser Glu Asp Ala Cys Glu Glu Pro Cys Phe Pro Ser Val His 
 785                790                795                800
Cys Val Pro Gly Lys Gly Cys Glu Ala Cys Pro Pro Asn Leu Thr Gly 
                 805                810                815
Asp Gly Arg His Cys Ala Ala Leu Gly Ser Ser Phe Leu Cys Gln Asn 
             820                825                830
Gln Ser Cys Pro Val Asn Tyr Cys Tyr Asn Gln Gly His Cys Tyr Ile 
         835                840                845
Ser Gln Thr Leu Gly Cys Gln Pro Met Cys Thr Cys Pro Pro Ala Phe 
     850                855                860
Thr Asp Ser Arg Cys Phe Leu Ala Gly Asn Asn Phe Ser Pro Thr Val 
 865                870                875                880
Asn Leu Glu Leu Pro Leu Arg Val Ile Gln Leu Leu Leu Ser Glu Glu 
                 885                890                895
Glu Asn Ala Ser Met Ala Glu Val Asn Ala Ser Val Ala Tyr Arg Leu 
             900                905                910
Gly Thr Leu Asp Met Arg Ala Phe Leu Arg Asn Ser Gln Val Glu Arg 
         915                920                925
Ile Asp Ser Ala Ala Pro Ala Ser Gly Ser Pro Ile Gln His Trp Met 
     930                935                940
Val Ile Ser Glu Phe Gln Tyr Arg Pro Arg Gly Pro Val Ile Asp Phe 
 945                950                955                960
Leu Asn Asn Gln Leu Leu Ala Ala Val Val Glu Ala Phe Leu Tyr His 
                 965                970                975
Val Pro Arg Arg Ser Glu Glu Pro Arg Asn Asp Val Val Phe Gln Pro 
             980                985                990
Ile Ser Glu Glu Asp Val Arg Asp Val Thr Ala Leu Asn Val Ser Thr 
         995                1000                1005
Leu Lys Ala Tyr Phe Arg Cys Asp Gly Tyr Lys Gly Tyr Asp Leu Val 
     1010                1015                1020
Tyr Ser Pro Gln Ser Gly Phe Thr Cys Val Ser Pro Cys Ser Arg Gly 
 1025                1030                1035                1040
Tyr Cys Asp His Gly Gly Gln Cys Gln His Leu Pro Ser Gly Pro Arg 
                 1045                1050                1055
Cys Ser Cys Val Ser Phe Ser Ile Tyr Thr Ala Trp Gly Glu His Cys 
             1060                1065                1070
Glu His Leu Ser Met Lys Leu Asp Ala Phe Phe Gly Ile Phe Phe Gly 
         1075                1080                1085
Ala Leu Gly Gly Leu Leu Leu Leu Gly Val Gly Thr Phe Val Val Leu 
     1090                1095                1100
Arg Phe Trp Gly Cys Ser Gly Ala Arg Phe Ser Tyr Phe Leu Asn Ser 
 1105                1110                1115                1120
Ala Glu Ala Leu Pro 
                 1125



<210> 8007
<211> 1217
<212> DNA
<213> Rattus norvegicus
<308> U07181
<400> 8007

cagagcctc  tcttgtctg  acaagatgg  aacccttaa  gaaaagctc  ttgcgccag  60
cgcagacga  gagactgcc  tcccgaaca  caagattac  gtagtaggc  ttggacaag  120
tggaatggc  tgtgctatc  gcattctgg  gaagtctct  gctgatgag  ttgccctgg  180
ggatgtctt  gaagacaag  tcaaaggag  aatgatgga  ctgcagcac  ggagcttat  240
tctccagac  ccgaaaatc  tggctgata  agattactc  gtgacagcc  attctaaga  300
tgtggtggt  accgcggga  tccgccagc  ggaggggga  agtcggctc  acctggtgc  360
gagaaacgt  aatgtattc  agttcatta  tcctcagat  gtcaagtac  gccccgact  420
caccatcat  gtggtttcc  acccagtgg  tattcttac  tatgtcacc  ggaagctga  480
cgggctacc  aagcaccgc  tgattggaa  tggatgcaa  ctggattct  ctcggtttc  540
ttacctcat  gccgaaaag  ttggtattc  tcccagcag  tgccacggc  ggatcctgg  600
cgagcacgg  gactccagt  tggcagtgt  gagcggggt  aatgtggca  gagtctccc  660
ccaggaact  aacccagag  tgggaacgg  caatgacag  gagaactgg  aggaggtgc  720
taagatggt  gtggacagt  cctatgaag  catcaagct  aaaggctac  ccaactggg  780
catcggcct  agtgtggct  acctcatcg  atccatgct  aaaaacctc  ctcggattc  840
ccccgtgtc  acaatggtg  agggaatgt  cggcatcga  aacgaagtc  tcctcagtc  900
cccgtgcat  cttaatgct  ggggactga  cagcgtcat  aaccagaag  tgaaggacg  960
tgaggtcgc  cagctcagg  agagtgcgg  caccctgtg  gatatccag  aagacctca  1020
ggacctgtg  ctgccaggc  ccaggctgt  gaaatccaa  cctccaatg  gactaagtg  1080
acctttagt  ttcggcctt  tacgtaggt  acagtttgc  tcttcccta  catgtgata  1140
tgagctcac  gatcaaaac  aggagtgtt  gatgtttgc  ctaggagct  ctgaacaaa  1200
aaagtttag  aattgca  1217



<210> 8008
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> P42123
<400> 8008

Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Asp Asp Glu Thr 
  1               5                  10                  15
Ala Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val Gly 
             20                  25                  30
Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu Leu 
         35                  40                  45
Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met Asp 
     50                  55                  60
Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala Asp 
 65                  70                  75                  80
Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr Ala 
                 85                  90                  95
Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg 
             100                105                110
Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr Ser 
         115                120                125
Pro Asp Cys Thr Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu Thr 
     130                135                140
Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile Gly 
 145                150                155                160
Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala Glu 
                 165                170                175
Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly Glu 
             180                185                190
His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala Gly 
         195                200                205
Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp Ser 
     210                215                220
Glu Asn Trp Lys Glu Val His Lys Met Val Val Asp Ser Ala Tyr Glu 
 225                230                235                240
Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser Val 
                 245                250                255
Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His Pro 
             260                265                270
Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val Phe 
         275                280                285
Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val Ile 
     290                295                300
Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Arg Lys Ser Ala 
 305                310                315                320
Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu 
                 325                330



<210> 8009
<211> 321
<212> DNA
<213> Homo sapiens
<308> BF913405
<400> 8009

cagggcaat  tctgaagga  caactcatc  caccagctg  ggaagaaga  gcaacaggt  60
ccaaacaag  aagatcact  tagggggtg  cggacaagt  ggtatggcg  gtgctatca  120
cattctggg  aagtctctg  ctgatgaac  tgctctggt  gagtgtttt  gaaggcagt  180
tttaagaca  aacacggga  atgatcaga  ttcctgaat  gagaaagct  atgtgcttc  240
ttacattgg  gaacaactg  agagattct  gactcaacc  tttagagct  agtccatgt  300
gcaacgaga  atgggcttt  g  321



<210> 8010
<211> 334
<212> PRT
<213> Homo sapiens
<308> NP_002291
<400> 8010

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu 
  1               5                  10                  15
Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
             20                  25                  30
Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
         35                  40                  45
Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
     50                  55                  60
Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
 65                  70                  75                  80
Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                 85                  90                  95
Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
             100                105                110
Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr 
         115                120                125
Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu 
     130                135                140
Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile 
 145                150                155                160
Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala 
                 165                170                175
Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly 
             180                185                190
Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala 
         195                200                205
Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp 
     210                215                220
Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr 
 225                230                235                240
Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser 
                 245                250                255
Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His 
             260                265                270
Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val 
         275                280                285
Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val 
     290                295                300
Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser 
 305                310                315                320
Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu 
                 325                330



<210> 8011
<211> 1217
<212> DNA
<213> Rattus norvegicus
<308> U07181
<400> 8011

cagagcctc  tcttgtctg  acaagatgg  aacccttaa  gaaaagctc  ttgcgccag  60
cgcagacga  gagactgcc  tcccgaaca  caagattac  gtagtaggc  ttggacaag  120
tggaatggc  tgtgctatc  gcattctgg  gaagtctct  gctgatgag  ttgccctgg  180
ggatgtctt  gaagacaag  tcaaaggag  aatgatgga  ctgcagcac  ggagcttat  240
tctccagac  ccgaaaatc  tggctgata  agattactc  gtgacagcc  attctaaga  300
tgtggtggt  accgcggga  tccgccagc  ggaggggga  agtcggctc  acctggtgc  360
gagaaacgt  aatgtattc  agttcatta  tcctcagat  gtcaagtac  gccccgact  420
caccatcat  gtggtttcc  acccagtgg  tattcttac  tatgtcacc  ggaagctga  480
cgggctacc  aagcaccgc  tgattggaa  tggatgcaa  ctggattct  ctcggtttc  540
ttacctcat  gccgaaaag  ttggtattc  tcccagcag  tgccacggc  ggatcctgg  600
cgagcacgg  gactccagt  tggcagtgt  gagcggggt  aatgtggca  gagtctccc  660
ccaggaact  aacccagag  tgggaacgg  caatgacag  gagaactgg  aggaggtgc  720
taagatggt  gtggacagt  cctatgaag  catcaagct  aaaggctac  ccaactggg  780
catcggcct  agtgtggct  acctcatcg  atccatgct  aaaaacctc  ctcggattc  840
ccccgtgtc  acaatggtg  agggaatgt  cggcatcga  aacgaagtc  tcctcagtc  900
cccgtgcat  cttaatgct  ggggactga  cagcgtcat  aaccagaag  tgaaggacg  960
tgaggtcgc  cagctcagg  agagtgcgg  caccctgtg  gatatccag  aagacctca  1020
ggacctgtg  ctgccaggc  ccaggctgt  gaaatccaa  cctccaatg  gactaagtg  1080
acctttagt  ttcggcctt  tacgtaggt  acagtttgc  tcttcccta  catgtgata  1140
tgagctcac  gatcaaaac  aggagtgtt  gatgtttgc  ctaggagct  ctgaacaaa  1200
aaagtttag  aattgca  1217



<210> 8012
<211> 333
<212> PRT
<213> Rattus norvegicus
<308> P42123
<400> 8012

Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Asp Asp Glu Thr 
  1               5                  10                  15
Ala Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val Gly 
             20                  25                  30
Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu Leu 
         35                  40                  45
Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met Asp 
     50                  55                  60
Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala Asp 
 65                  70                  75                  80
Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr Ala 
                 85                  90                  95
Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg 
             100                105                110
Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr Ser 
         115                120                125
Pro Asp Cys Thr Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu Thr 
     130                135                140
Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile Gly 
 145                150                155                160
Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala Glu 
                 165                170                175
Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly Glu 
             180                185                190
His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala Gly 
         195                200                205
Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp Ser 
     210                215                220
Glu Asn Trp Lys Glu Val His Lys Met Val Val Asp Ser Ala Tyr Glu 
 225                230                235                240
Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser Val 
                 245                250                255
Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His Pro 
             260                265                270
Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val Phe 
         275                280                285
Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val Ile 
     290                295                300
Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Arg Lys Ser Ala 
 305                310                315                320
Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu 
                 325                330



<210> 8013
<211> 321
<212> DNA
<213> Homo sapiens
<308> BF913405
<400> 8013

cagggcaat  tctgaagga  caactcatc  caccagctg  ggaagaaga  gcaacaggt  60
ccaaacaag  aagatcact  tagggggtg  cggacaagt  ggtatggcg  gtgctatca  120
cattctggg  aagtctctg  ctgatgaac  tgctctggt  gagtgtttt  gaaggcagt  180
tttaagaca  aacacggga  atgatcaga  ttcctgaat  gagaaagct  atgtgcttc  240
ttacattgg  gaacaactg  agagattct  gactcaacc  tttagagct  agtccatgt  300
gcaacgaga  atgggcttt  g  321



<210> 8014
<211> 334
<212> PRT
<213> Homo sapiens
<308> NP_002291
<400> 8014

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu 
  1               5                  10                  15
Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
             20                  25                  30
Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
         35                  40                  45
Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
     50                  55                  60
Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
 65                  70                  75                  80
Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                 85                  90                  95
Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
             100                105                110
Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr 
         115                120                125
Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu 
     130                135                140
Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile 
 145                150                155                160
Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala 
                 165                170                175
Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly 
             180                185                190
Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala 
         195                200                205
Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp 
     210                215                220
Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr 
 225                230                235                240
Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser 
                 245                250                255
Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His 
             260                265                270
Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val 
         275                280                285
Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val 
     290                295                300
Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser 
 305                310                315                320
Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu 
                 325                330



<210> 8015
<211> 2370
<212> DNA
<213> Rattus norvegicus
<308> U08214
<400> 8015

gtggaattc  tagagccaa  tgtgaatga  agcaataat  tatacattc  agtagccag  60
gaggacaag  tttgccatg  aagatccag  ttacaaaac  ctaatgcag  tcaaactca  120
aatgatgac  cattccaac  ttcaatcag  aagggctac  aagacccta  ctaaaaaaa  180
aagaaacaa  aaccaaatc  agtcaataa  ccaaagtac  actatagga  gatttgtaa  240
tgttaaatt  ttttaccaa  gatctttat  tttaaaata  gcccaactt  aatcaaagt  300
aagttttta  tgttaattc  ttatacaaa  caatcttta  agtgacagt  ctgagtttc  360
ctgtgtcac  ttggctgtc  tccaacaga  gttgacctg  ctctgcctg  ccgagtgct  420
cgattgaag  ccgtgccac  aacgctcga  gccttaaag  tgataacct  caaaattct  480
ctttaaaga  tattctatt  tgacgtaag  ctgtaaatc  taccacttg  gaggtctct  540
atataatta  atcacaagt  taaggtcag  ttgtgtcac  cagttcaag  ctagactga  600
cttcttcac  gcaagacct  atctcaaaa  caagcaaaa  cataaacaa  aaaggaaaa  660
aagaaaaaa  aaaaaaacc  acccaacta  aataagatc  caactcaag  attttaagt  720
taacaaaca  acttaagac  tctcccaaa  aaaaaaaag  atattccca  aaatataga  780
actctctat  tcaatgatt  tgtatatat  cttagagaa  aaacatttt  ttggcacag  840
ggcagagct  aaacaatgt  ttactatgt  agacattct  tcgtgccga  ttcggcacg  900
gagaagaag  gcaggatgc  gggggtcta  tgcgagagt  gtacatgat  atctctcga  960
agatgttca  ccctatgta  gccttgttc  gtacctcac  tggtgaccg  gtcactaca  1020
gatcaatcc  tcttcccac  gtaacccca  ccacctcag  tacttcaag  ttagctgga  1080
gatatgtag  caaagctgt  atgacaacc  ccctcctgg  gtgctactt  actaggtct  1140
tctacaaac  catcttggg  aaatctgtc  ggtatacag  tatggagag  gaggattac  1200
acttctacc  gggtctagt  tatctgctt  aaaatgatg  ctctacatt  ggttatgac  1260
tcaccttca  cactgaggt  caagaattt  gagtatgtg  ggttcgtga  ctcaaaccc  1320
atggagcca  catcttagt  acagaggag  acaagaagg  atatgtaca  ctggtttgc  1380
agatgagaa  gacaggagc  atccgcaaa  agctggcag  cttcttaga  ggcttctat  1440
aaatcattc  aaagcgcct  atatccatc  ttactgagc  ggagttaga  ctgctctat  1500
cagggctgc  taccatcga  atagatgac  taaaatcta  cactgagta  cacaagtac  1560
agtccaact  cattcagat  caatggttc  ggagagcat  gcgttcctt  gaccaagca  1620
accgtgcca  gttcctcca  tttgtcaca  gtacttcca  ggtgcccct  caaggattt  1680
ctgcccttg  aggcatgaa  ggcattcag  agtttcaga  tcatcgaga  gacagatcc  1740
cagatcgcc  gccttcagc  cacacatgt  ttaatcaac  ggacctgcc  gcctatgag  1800
gctttgaga  gctccgcca  atgctacta  tggccatcc  ggagtgctc  gaaggcttt  1860
ggctggcta  taaataagg  cctgcctac  tctgtgggg  ttttctacc  tttttggac  1920
tggggaggg  ggggggttt  aaagatcca  aaagaaaat  tcaaaatcc  ataaatgaa  1980
ttcaccaac  caccatgtg  gtgtccagc  gcccatctt  ctagtgcat  cctgttcgc  2040
tctcattct  tttcctcta  cctttcctt  cctttccct  ttccatgcc  tccatgatc  2100
ccaccccat  tgttaagaa  gcagttgct  tgcagggac  tgtttgtcc  actgaacag  2160
gtgctcctc  gattctgtg  tcagaagga  ttgctgcat  gagacttga  acctttggt  2220
aggggaaaa  tatatatat  tatattttt  tgttctgtt  gcatttctt  atttgtgct  2280
ggaatgtgt  gatgtgcac  gctaatgat  caatgcgag  caagattgg  atctgtgtt  2340
tggaggttc  aataaagag  actcttcata  2370



<210> 8016
<211> 310
<212> PRT
<213> Rattus norvegicus
<308> AAA81950
<400> 8016

Met Ile Ile Ser Arg Glu Met Phe Asn Pro Met Tyr Ala Leu Phe Arg 
  1               5                  10                  15
Thr Ser Pro Gly Asp Arg Val Thr Thr Arg Ser Ile His Leu Pro Thr 
             20                  25                  30
Val Thr Pro Thr Thr Ser Ala Thr Ser Ser Leu Ala Gly Arg Tyr Val 
         35                  40                  45
Ala Lys Ala Val Met Thr Thr Ala Leu Leu Glu Cys Tyr Phe Thr Arg 
     50                  55                  60
Ser Phe Tyr Lys His Ile Leu Gly Lys Ser Val Arg Tyr Thr Asp Met 
 65                  70                  75                  80
Glu Ser Glu Asp Tyr His Phe Tyr Gln Gly Leu Val Tyr Leu Leu Glu 
                 85                  90                  95
Asn Asp Val Ser Thr Leu Gly Tyr Asp Leu Thr Phe Ser Thr Glu Val 
             100                105                110
Gln Glu Phe Gly Val Cys Glu Val Arg Asp Leu Lys Pro Asn Gly Ala 
         115                120                125
Asn Ile Leu Val Thr Glu Glu Asn Lys Lys Glu Tyr Val His Leu Val 
     130                135                140
Cys Gln Met Arg Met Thr Gly Ala Ile Arg Lys Gln Leu Ala Ala Phe 
 145                150                155                160
Leu Glu Gly Phe Tyr Glu Ile Ile Pro Lys Arg Leu Ile Ser Ile Phe 
                 165                170                175
Thr Glu Gln Glu Leu Glu Leu Leu Tyr Thr Gly Leu Pro Thr Ile Asp 
             180                185                190
Ile Asp Asp Leu Lys Ser Asn Thr Glu Tyr His Lys Tyr Gln Ser Asn 
         195                200                205
Ser Ile Gln Ile Gln Trp Phe Trp Arg Ala Leu Arg Ser Phe Asp Gln 
     210                215                220
Ala Asp Arg Ala Lys Phe Leu Gln Phe Val Thr Gly Thr Ser Lys Val 
 225                230                235                240
Pro Leu Gln Gly Phe Ala Ala Leu Glu Gly Met Asn Gly Ile Gln Lys 
                 245                250                255
Phe Gln Ile His Arg Asp Asp Arg Ser Thr Asp Arg Leu Pro Ser Ala 
             260                265                270
His Thr Cys Phe Asn Gln Leu Asp Leu Pro Ala Tyr Glu Ser Phe Glu 
         275                280                285
Lys Leu Arg His Met Leu Leu Leu Ala Ile Gln Glu Cys Ser Glu Gly 
     290                295                300
Phe Gly Leu Ala Asn Lys 
 305                310



<210> 8017
<211> 3312
<212> DNA
<213> Rattus norvegicus
<308> U08257
<400> 8017

cttttctgg  tcttgttgt  ccggagcgt  atgtcatgc  cagaccagc  gagggctcc  60
tgaggagtt  tagaagatg  cccgtgtct  tgctcctct  gtgctgctt  ctgcttggc  120
cttgatggt  gcctgtagc  cacactccc  gaggatcgc  gctatcttg  atgacccca  180
ggagtgcag  agaggggaa  ggctctcca  caccctggc  aagaaccgc  tcaaccgcg  240
accagagag  ctgggcaag  caaaagtcg  agtggacat  tttgagctt  tcagagaca  300
cgagtacga  actgcagaa  ccatgtgtc  gatcctccc  aagggagtg  tcgctgtcc  360
gggaccgtc  tccagccca  cctccagct  catcatcag  aacatctgt  gagagaagg  420
ggtccctca  ttcaaagtg  ccccagagg  gtttgtcag  ttccaactc  agagattca  480
caccctgaa  cttcacccc  gcaacaccg  catcagcgt  gctgtggct  ggatcctga  540
cttcttcaa  tgcaccacc  cctgcctca  ctgtgccaa  gcagaatgc  ttttaaacc  600
ggagaagct  ctccggcaa  tccttatct  caaggacac  ctgtcggtc  ggatgctgg  660
tgacacacg  gaccccact  cgctcctca  ggagatccg  gatgacaag  cagctacta  720
catcatcca  gccaacgcc  ccatgtcgc  caccatcct  ctgaaggca  ctgaactgg  780
gatggtgtc  gcctattac  cctacatct  caccaatct  gagttctcc  tccagagaa  840
ggacagcct  gtggatgat  gagtcaaca  cttaggatt  tccattttc  accaatccc  900
tgctttctt  caagagttc  cccagagcc  caaccaatc  tggcaggag  actgtgacc  960
cgtgccctt  accggccct  cgttgtcct  agccctact  tttgacgct  tctacgctg  1020
ggtgacagc  gtacaggaa  tgaaccgga  ccaggaaat  ggcgtgaag  ccctgtcct  1080
tggctcggc  cagatctgg  agcatggca  cagcctcat  aactacctg  gcatggtag  1140
attggaagg  cttaccggc  acattgaat  caacagcaa  ggccagagg  ccaactatg  1200
cttgaaaat  ttacagttc  ccaggaatg  gtttcggca  attggccag  ggcatgtgg  1260
agagggcct  agcatggac  gccgcctct  cgcctccaa  atctctgac  gtctcttca  1320
caccaccct  gtcgtcacc  ccatcctgg  aaacccata  ctaatgctg  aggggaacc  1380
ccaggacat  gaaggcaat  accggtacg  gggattctg  gtggacatg  tcaaggagt  1440
ggctgagat  ctacggttc  actacaaga  ccgcctcgt  ggggatggt  tttacggcg  1500
acctgaggc  aacggcacc  ggacgggca  ggttgggga  ctgatcgct  ggaaagcag  1560
tctggctgt  gcgggcctc  ccatcacag  tgaacgtga  aaagtgatt  atttctcca  1620
gccgttcat  acgctggga  ttagtattc  ttacagagt  catatggga  gcagaccgg  1680
ctatttctc  tttctggac  ccttttctc  aggagtctg  ctcttcatg  ttctagctt  1740
tctggctgt  agctgtgtc  tcttcctgg  ggctcggtt  actccttat  agtggtaca  1800
tccacatcc  tgtgcacag  gccggtgta  tctcctggt  aaccagtac  ctctgggca  1860
cagcctctg  tttccagtg  gaggcttca  gcagcaagg  tccaccatc  ccccgcggg  1920
tttgtccac  cgctgcgtc  gtggtgtct  gtgggcctt  acgttgatc  tcatctcat  1980
gtacacagc  aacctggca  ccttcctga  ggtgcagcg  atggaagtg  ccatcgagt  2040
tgtggatga  ctggctgac  agaccgcca  tgagtatgg  acgattcac  gaggctcca  2100
catgacctt  ttccaaaat  cccgctacc  gacctacca  cgcatgtgg  attacatgt  2160
ctccaagca  cccagtgtg  ttgtgaaga  cacagagga  ggaattgcc  gggtgttga  2220
ttccaacta  gccttcctg  tggagtcca  catgaacga  tactaccgg  agaggaact  2280
caacctcac  cagattggg  gcctgctgg  caccaaggg  tatgggatt  gcatgccag  2340
cggctcagt  ttccgggat  agttcgacc  ggccattct  cagctgcag  agaacaacc  2400
cctggagat  ctgaagcgg  agtggtggg  agggggaaa  tgtcccaag  aggaggacc  2460
cagagccaa  ggcctggga  tggagaata  tggtggaat  tttgtggtt  ttatttgtg  2520
cttaatagt  gccattttt  tggctatgc  ggagttttt  tggactctc  gacactcag  2580
agcatcaga  gtgtctgtg  gtcaggaga  gatgactga  ctgcgcagc  tcatcctgt  2640
ccaggacaa  atccatccc  ggaggcggc  ctctggagg  ctgccaccc  agcccccgg  2700
cctggagga  cgccggccc  ggggtacag  gacgctcag  aatggcaag  tatgtggcg  2760
cggggagcc  gaccaactg  cgcagagac  ggctcagga  gccgccctg  tggcccgag  2820
ctgcacgca  atccgcgtg  gcccggagt  ccgccgctt  cagggcctg  gggctcgac  2880
gtcgccagc  cgcagcgag  agagcctgg  gtgggacaa  accaccaac  gcagcgagc  2940
tgagtagtg  cggcgaagg  ccgtggagc  aggcgggga  gcgggaggg  taatgttac  3000
acctccttc  ctccgattg  agattcagt  actttacaa  gtcactgat  gcccagcta  3060
ggcggatcc  gccctatct  agacttgca  acacgtggc  gagacattg  ccctcttgg  3120
cacaaggac  catctcctc  agagggtct  tccctcaca  tcaaaaaca  ggattctgg  3180
tagtggggc  ctgctgaga  agcagtcca  gaaattgat  gtatcatca  ttggattac  3240
ccctaggaa  gggccattg  accctgggt  tagttctta  aggaaaaaa  aaattaaac  3300
caacaggga  gg  3312



<210> 8018
<211> 956
<212> PRT
<213> Rattus norvegicus
<308> Q01812
<400> 8018

Met Pro Arg Val Ser Ala Pro Leu Val Leu Leu Pro Ala Trp Leu Leu 
  1               5                  10                  15
Met Val Ala Cys Ser Pro His Ser Leu Arg Ile Ala Ala Ile Leu Asp 
             20                  25                  30
Asp Pro Met Glu Cys Ser Arg Gly Glu Arg Leu Ser Ile Thr Leu Ala 
         35                  40                  45
Lys Asn Arg Ile Asn Arg Ala Pro Glu Arg Leu Gly Lys Ala Lys Val 
     50                  55                  60
Glu Val Asp Ile Phe Glu Leu Leu Arg Asp Ser Glu Tyr Glu Thr Ala 
 65                  70                  75                  80
Glu Thr Met Cys Gln Ile Leu Pro Lys Gly Val Val Ala Val Leu Gly 
                 85                  90                  95
Pro Ser Ser Ser Pro Ala Ser Ser Ser Ile Ile Ser Asn Ile Cys Gly 
             100                105                110
Glu Lys Glu Val Pro His Phe Lys Val Ala Pro Glu Glu Phe Val Arg 
         115                120                125
Phe Gln Leu Gln Arg Phe Thr Thr Leu Asn Leu His Pro Ser Asn Thr 
     130                135                140
Asp Ile Ser Val Ala Val Ala Gly Ile Leu Asn Phe Phe Asn Cys Thr 
 145                150                155                160
Thr Ala Cys Leu Ile Cys Ala Lys Ala Glu Cys Leu Leu Asn Leu Glu 
                 165                170                175
Lys Leu Leu Arg Gln Phe Leu Ile Ser Lys Asp Thr Leu Ser Val Arg 
             180                185                190
Met Leu Asp Asp Thr Arg Asp Pro Thr Pro Leu Leu Lys Glu Ile Arg 
         195                200                205
Asp Asp Lys Thr Ala Thr Ile Ile Ile His Ala Asn Ala Ser Met Ser 
     210                215                220
His Thr Ile Leu Leu Lys Ala Ala Glu Leu Gly Met Val Ser Ala Tyr 
 225                230                235                240
Tyr Thr Tyr Ile Phe Thr Asn Leu Glu Phe Ser Leu Gln Arg Met Asp 
                 245                250                255
Ser Leu Val Asp Asp Arg Val Asn Ile Leu Gly Phe Ser Ile Phe Asn 
             260                265                270
Gln Ser His Ala Phe Phe Gln Glu Phe Ser Gln Ser Leu Asn Gln Ser 
         275                280                285
Trp Gln Glu Asn Cys Asp His Val Pro Phe Thr Gly Pro Ala Leu Ser 
     290                295                300
Ser Ala Leu Leu Phe Asp Ala Val Tyr Ala Val Val Thr Ala Val Gln 
 305                310                315                320
Glu Leu Asn Arg Ser Gln Glu Ile Gly Val Lys Pro Leu Ser Cys Gly 
                 325                330                335
Ser Ala Gln Ile Trp Gln His Gly Thr Ser Leu Met Asn Tyr Leu Arg 
             340                345                350
Met Val Glu Leu Glu Gly Leu Thr Gly His Ile Glu Phe Asn Ser Lys 
         355                360                365
Gly Gln Arg Ser Asn Tyr Ala Leu Lys Ile Leu Gln Phe Thr Arg Asn 
     370                375                380
Gly Phe Arg Gln Ile Gly Gln Trp His Val Ala Glu Gly Leu Ser Met 
 385                390                395                400
Asp Ser Arg Leu Tyr Ala Ser Asn Ile Ser Asp Ser Leu Phe Asn Thr 
                 405                410                415
Thr Leu Val Val Thr Thr Ile Leu Glu Asn Pro Tyr Leu Met Leu Lys 
             420                425                430
Gly Asn His Gln Asp Met Glu Gly Asn Asp Arg Tyr Glu Gly Phe Cys 
         435                440                445
Val Asp Met Leu Lys Glu Leu Ala Glu Ile Leu Arg Phe Asn Tyr Lys 
     450                455                460
Ile Arg Leu Val Gly Asp Gly Val Tyr Gly Val Pro Glu Ala Asn Gly 
 465                470                475                480
Thr Trp Thr Gly Met Val Gly Glu Leu Ile Ala Arg Lys Ala Asp Leu 
                 485                490                495
Ala Val Ala Gly Leu Thr Ile Thr Ala Glu Arg Glu Lys Val Ile Asp 
             500                505                510
Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Val 
         515                520                525
His Met Gly Arg Arg Pro Gly Tyr Phe Ser Ser Leu Asp Pro Phe Ser 
     530                535                540
Pro Gly Val Trp Leu Phe Met Leu Leu Ala Tyr Leu Ala Val Ser Cys 
 545                550                555                560
Val Leu Phe Leu Val Ala Arg Leu Thr Pro Tyr Glu Trp Tyr Ser Pro 
                 565                570                575
His Pro Cys Ala Gln Gly Arg Cys Asn Leu Leu Val Asn Gln Tyr Ser 
             580                585                590
Leu Gly Asn Ser Leu Trp Phe Pro Val Gly Gly Phe Met Gln Gln Gly 
         595                600                605
Ser Thr Ile Ala Pro Arg Ala Leu Ser Thr Arg Cys Val Ser Gly Val 
     610                615                620
Trp Trp Ala Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu 
 625                630                635                640
Ala Ala Phe Leu Thr Val Gln Arg Met Glu Val Pro Ile Glu Ser Val 
                 645                650                655
Asp Asp Leu Ala Asp Gln Thr Ala Ile Glu Tyr Gly Thr Ile His Gly 
             660                665                670
Gly Ser Ser Met Thr Phe Phe Gln Asn Ser Arg Tyr Gln Thr Tyr Gln 
         675                680                685
Arg Met Trp Asn Tyr Met Tyr Ser Lys Gln Pro Ser Val Phe Val Lys 
     690                695                700
Ser Thr Glu Glu Gly Ile Ala Arg Val Leu Asn Ser Asn Tyr Ala Phe 
 705                710                715                720
Leu Leu Glu Ser Thr Met Asn Glu Tyr Tyr Arg Gln Arg Asn Cys Asn 
                 725                730                735
Leu Thr Gln Ile Gly Gly Leu Leu Asp Thr Lys Gly Tyr Gly Ile Gly 
             740                745                750
Met Pro Val Gly Ser Val Phe Arg Asp Glu Phe Asp Leu Ala Ile Leu 
         755                760                765
Gln Leu Gln Glu Asn Asn Arg Leu Glu Ile Leu Lys Arg Lys Trp Trp 
     770                775                780
Glu Gly Gly Lys Cys Pro Lys Glu Glu Asp His Arg Ala Lys Gly Leu 
 785                790                795                800
Gly Met Glu Asn Ile Gly Gly Ile Phe Val Val Leu Ile Cys Gly Leu 
                 805                810                815
Ile Val Ala Ile Phe Met Ala Met Leu Glu Phe Leu Trp Thr Leu Arg 
             820                825                830
His Ser Glu Ala Ser Glu Val Ser Val Cys Gln Glu Met Met Thr Glu 
         835                840                845
Leu Arg Ser Ile Ile Leu Cys Gln Asp Asn Ile His Pro Arg Arg Arg 
     850                855                860
Arg Ser Gly Gly Leu Pro Pro Gln Pro Pro Val Leu Glu Glu Arg Arg 
 865                870                875                880
Pro Arg Gly Thr Ala Thr Leu Ser Asn Gly Lys Leu Cys Gly Ala Gly 
                 885                890                895
Glu Pro Asp Gln Leu Ala Gln Arg Leu Ala Gln Glu Ala Ala Leu Val 
             900                905                910
Ala Arg Gly Cys Thr His Ile Arg Val Cys Pro Glu Cys Arg Arg Phe 
         915                920                925
Gln Gly Leu Arg Ala Arg Pro Ser Pro Ala Arg Ser Glu Glu Ser Leu 
     930                935                940
Glu Trp Asp Lys Thr Thr Asn Ser Ser Glu Pro Glu 
 945                950                955



<210> 8019
<211> 2871
<212> DNA
<213> Homo sapiens
<308> S67803
<400> 8019

atgccccgc  tctcggcgc  tttggtgct  cttcctgcg  ggctcgtga  ggtcgcctg  60
agcccgcac  ccttgagga  cgctgctat  ttggacgac  ccatggagt  cagcagagg  120
gagcggctc  ccatcaccc  ggccaagaa  cgcatcaac  gcgctcctg  gaggctggg  180
aaggccaag  tcgaagtgg  catctttga  cttctcaga  acagcgagt  cgagactgc  240
gaaaccatg  gtcagatcc  ccccaaggg  gtggtcgct  tcctcggac  atcgtccag  300
ccagcctcc  gctccatca  cagcaacat  tgtggagag  aggaggtcc  tcacttcaa  360
gtggcccca  aggagttcg  caagttcca  ttccagaga  tcacaaccc  gaacctcca  420
cccagcaac  ctgacatca  cgtggctgt  gctgggatc  tgaacttct  caactgcac  480
accgcctgc  tcatctgtg  caaagcaga  tgcctttta  acctagaga  gctgctccg  540
caattcctt  tctccaagg  cacgctgtc  gtccgcatg  tggatgaca  ccgggaccc  600
accccgctc  tcaaggaga  ccgggacga  aagaccgcc  ccatcatca  ccacgccaa  660
gcctccatg  cccacacca  cctcctgaa  gcagccgaa  ttgggatgg  gtcagccta  720
tacacatac  tcttcacta  tctggagtt  tcactccag  gaacggaca  ccttgtgga  780
gatcgtgtc  acatcctgg  attttccat  ttcaaccaa  cccatgctt  cttccaaga  840
tttgcccag  gcctcaacc  gtcctggca  gagaactgt  accatgtgc  cttcactgg  900
cctgcgctc  cctcggccc  gctgtttga  gctgtctat  ctgtggtga  tgcggtgca  960
gaactgaac  ggagccaag  gatcggcgt  aagcccttg  cctgcggct  ggcccagat  1020
tggcagcac  gcaccagcc  catgaacta  ctgcgcatg  tagaattgg  aggtcttac  1080
ggccacatt  aattcaaca  caaaggcca  aggtccaac  acgctttga  aatcttaca  1140
ttcacaagg  atggttttc  gcagatcgg  cagtggcac  tggcagagg  cctcagcat  1200
gacagccac  tctatgcct  caacatctc  gacactctc  tcaacacca  cctggtcgt  1260
accaccatc  tggaaaacc  atatttaat  ctgaagggg  accaccagg  gatggaagg  1320
aatgaccgc  acgagggct  ctgtgtgga  atgctcaag  agctggcag  gatcctccg  1380
ttcaactac  agatccgcc  ggttgggga  ggcgtgtac  gcgttcccg  ggccaacgg  1440
acctggacg  gaatggtcg  ggagctgat  gctaggaaa  cagatctgg  tgtggcagg  1500
ctcaccatt  cagctgaac  ggagaaggt  attgatttc  ctaagccat  catgactct  1560
ggaattagc  ttctttacc  cattcatat  ggacgcaaa  ccggctatt  ctccttcct  1620
gacccattt  ctccgggcg  ctggctctt  atgcttcta  cctatctgg  cgtcagctg  1680
gtcctcttc  tggtggctc  gttgacgcc  tacgagtgg  acagcccac  cccatgtgc  1740
cagggccgg  gcaacctcc  ggtgaacca  tactccctg  gcaacagcc  ctggtttcc  1800
gtcgggggg  tcatgcagc  gggctccac  atcgcccct  gcgccttat  cacccgctg  1860
gtcagtggc  tctggtggg  attcacgct  atcatcatc  catcctaca  ggccaacct  1920
gcagccttc  tgaccgtgc  gcgcatgga  gtgcccatt  agtcagtgg  tgacctggc  1980
gaccagacc  ccattgaat  tggcacaat  cacggaggc  ccagcatga  cttcttcca  2040
aattcccgc  accagacct  ccaacgcat  tggaattac  tgtattcca  gcagcccag  2100
gtgttcgtg  agagcacag  ggagggaat  gccagggtg  tgaattcca  ctacgcctt  2160
ctcctggaa  ccaccatga  cgagtacta  cggcagcga  actgcaacc  cactcagat  2220
gggggcctg  tggacacca  gggctatgg  attggcatg  cagtcggct  ggttttccg  2280
gacgagttt  atctggcca  tctccagct  caggagaac  accgcctgg  gatcctgaa  2340
cgcaaatgg  gggaaggag  gaagtgccc  aaggaggaa  atcacagag  taaaggcct  2400
ggaatggag  atattggtg  aatctttgt  gttcttatt  gtggcttaa  cgtggccat  2460
tttatggct  tgttggagt  tttatggac  ctcagacac  cagaagcaa  tgaggtgtc  2520
gtctgccag  agatggtga  cgagctgcg  agcattatc  tgtgtcagg  cagtatcca  2580
ccccgccgg  ggcgcgccg  agtcccgcc  ccccggccc  ccatccccg  ggagcgccg  2640
ccgcggggc  cggcgacgc  cagcaacgg  aagctgtgc  gggcagggg  gcccgacca  2700
ctcgcgcag  gactggcgc  ggaggccgc  ctggtggcc  gcggctgca  gcacatccg  2760
gtctgcccc  agtgccgcc  cttccaggg  ctgcgggca  ggccgtcgc  cgcccgcag  2820
gaggagagc  tggagtggg  gaaaaccac  aacagcagc  agcccgagt  g  2871



<210> 8020
<211> 956
<212> PRT
<213> Homo sapiens
<308> Q16099
<400> 8020

Met Pro Arg Val Ser Ala Pro Leu Val Leu Leu Pro Ala Trp Leu Val 
  1               5                  10                  15
Met Val Ala Cys Ser Pro His Ser Leu Arg Ile Ala Ala Ile Leu Asp 
             20                  25                  30
Asp Pro Met Glu Cys Ser Arg Gly Glu Arg Leu Ser Ile Thr Leu Ala 
         35                  40                  45
Lys Asn Arg Ile Asn Arg Ala Pro Glu Arg Leu Gly Lys Ala Lys Val 
     50                  55                  60
Glu Val Asp Ile Phe Glu Leu Leu Arg Asp Ser Glu Tyr Glu Thr Ala 
 65                  70                  75                  80
Glu Thr Met Cys Gln Ile Leu Pro Lys Gly Val Val Ala Val Leu Gly 
                 85                  90                  95
Pro Ser Ser Ser Pro Ala Ser Ser Ser Ile Ile Ser Asn Ile Cys Gly 
             100                105                110
Glu Lys Glu Val Pro His Phe Lys Val Ala Pro Glu Glu Phe Val Lys 
         115                120                125
Phe Gln Phe Gln Arg Phe Thr Thr Leu Asn Leu His Pro Ser Asn Thr 
     130                135                140
Asp Ile Ser Val Ala Val Ala Gly Ile Leu Asn Phe Phe Asn Cys Thr 
 145                150                155                160
Thr Ala Cys Leu Ile Cys Ala Lys Ala Glu Cys Leu Leu Asn Leu Glu 
                 165                170                175
Lys Leu Leu Arg Gln Phe Leu Ile Ser Lys Asp Thr Leu Ser Val Arg 
             180                185                190
Met Leu Asp Asp Thr Arg Asp Pro Thr Pro Leu Leu Lys Glu Ile Arg 
         195                200                205
Asp Asp Lys Thr Ala Thr Ile Ile Ile His Ala Asn Ala Ser Met Ser 
     210                215                220
His Thr Ile Leu Leu Lys Ala Ala Glu Leu Gly Met Val Ser Ala Tyr 
 225                230                235                240
Tyr Thr Tyr Ile Phe Thr Asn Leu Glu Phe Ser Leu Gln Arg Thr Asp 
                 245                250                255
Ser Leu Val Asp Asp Arg Val Asn Ile Leu Gly Phe Ser Ile Phe Asn 
             260                265                270
Gln Ser His Ala Phe Phe Gln Glu Phe Ala Gln Ser Leu Asn Gln Ser 
         275                280                285
Trp Gln Glu Asn Cys Asp His Val Pro Phe Thr Gly Pro Ala Leu Ser 
     290                295                300
Ser Ala Leu Leu Phe Asp Ala Val Tyr Ala Val Val Thr Ala Val Gln 
 305                310                315                320
Glu Leu Asn Arg Ser Gln Glu Ile Gly Val Lys Pro Leu Ser Cys Gly 
                 325                330                335
Ser Ala Gln Ile Trp Gln His Gly Thr Ser Leu Met Asn Tyr Leu Arg 
             340                345                350
Met Val Glu Leu Glu Gly Leu Thr Gly His Ile Glu Phe Asn Ser Lys 
         355                360                365
Gly Gln Arg Ser Asn Tyr Ala Leu Lys Ile Leu Gln Phe Thr Arg Asn 
     370                375                380
Gly Phe Arg Gln Ile Gly Gln Trp His Val Ala Glu Gly Leu Ser Met 
 385                390                395                400
Asp Ser His Leu Tyr Ala Ser Asn Ile Ser Asp Thr Leu Phe Asn Thr 
                 405                410                415
Thr Leu Val Val Thr Thr Ile Leu Glu Asn Pro Tyr Leu Met Leu Lys 
             420                425                430
Gly Asn His Gln Glu Met Glu Gly Asn Asp Arg Tyr Glu Gly Phe Cys 
         435                440                445
Val Asp Met Leu Lys Glu Leu Ala Glu Ile Leu Arg Phe Asn Tyr Lys 
     450                455                460
Ile Arg Leu Val Gly Asp Gly Val Tyr Gly Val Pro Glu Ala Asn Gly 
 465                470                475                480
Thr Trp Thr Gly Met Val Gly Glu Leu Ile Ala Arg Lys Ala Asp Leu 
                 485                490                495
Ala Val Ala Gly Leu Thr Ile Thr Ala Glu Arg Glu Lys Val Ile Asp 
             500                505                510
Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Ile 
         515                520                525
His Met Gly Arg Lys Pro Gly Tyr Phe Ser Phe Leu Asp Pro Phe Ser 
     530                535                540
Pro Gly Val Trp Leu Phe Met Leu Leu Ala Tyr Leu Ala Val Ser Cys 
 545                550                555                560
Val Leu Phe Leu Val Ala Arg Leu Thr Pro Tyr Glu Trp Tyr Ser Pro 
                 565                570                575
His Pro Cys Ala Gln Gly Arg Cys Asn Leu Leu Val Asn Gln Tyr Ser 
             580                585                590
Leu Gly Asn Ser Leu Trp Phe Pro Val Gly Gly Phe Met Gln Gln Gly 
         595                600                605
Ser Thr Ile Ala Pro Arg Ala Leu Ser Thr Arg Cys Val Ser Gly Val 
     610                615                620
Trp Trp Ala Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu 
 625                630                635                640
Ala Ala Phe Leu Thr Val Gln Arg Met Asp Val Pro Ile Glu Ser Val 
                 645                650                655
Asp Asp Leu Ala Asp Gln Thr Ala Ile Glu Tyr Gly Thr Ile His Gly 
             660                665                670
Gly Ser Ser Met Thr Phe Phe Gln Asn Ser Arg Tyr Gln Thr Tyr Gln 
         675                680                685
Arg Met Trp Asn Tyr Met Tyr Ser Lys Gln Pro Ser Val Phe Val Lys 
     690                695                700
Ser Thr Glu Glu Gly Ile Ala Arg Val Leu Asn Ser Asn Tyr Ala Phe 
 705                710                715                720
Leu Leu Glu Ser Thr Met Asn Glu Tyr Tyr Arg Gln Arg Asn Cys Asn 
                 725                730                735
Leu Thr Gln Ile Gly Gly Leu Leu Asp Thr Lys Gly Tyr Gly Ile Gly 
             740                745                750
Met Pro Val Gly Ser Val Phe Arg Asp Glu Phe Asp Leu Ala Ile Leu 
         755                760                765
Gln Leu Gln Glu Asn Asn Arg Leu Glu Ile Leu Lys Arg Lys Trp Trp 
     770                775                780
Glu Gly Gly Lys Cys Pro Lys Glu Glu Asp His Arg Ala Lys Gly Leu 
 785                790                795                800
Gly Met Glu Asn Ile Gly Gly Ile Phe Val Val Leu Ile Cys Gly Leu 
                 805                810                815
Ile Val Ala Ile Phe Met Ala Met Leu Glu Phe Leu Trp Thr Leu Arg 
             820                825                830
His Ser Glu Ala Thr Glu Val Ser Val Cys Gln Glu Met Val Thr Glu 
         835                840                845
Leu Arg Ser Ile Ile Leu Cys Gln Asp Ser Ile His Pro Arg Arg Arg 
     850                855                860
Arg Ala Ala Val Pro Pro Pro Arg Pro Pro Ile Pro Glu Glu Arg Arg 
 865                870                875                880
Pro Arg Gly Thr Ala Thr Leu Ser Asn Gly Lys Leu Cys Gly Ala Gly 
                 885                890                895
Glu Pro Asp Gln Leu Ala Gln Arg Leu Ala Gln Glu Ala Ala Leu Val 
             900                905                910
Ala Arg Gly Cys Thr His Ile Arg Val Cys Pro Glu Cys Arg Arg Phe 
         915                920                925
Gln Gly Leu Arg Ala Arg Pro Ser Pro Ala Arg Ser Glu Glu Ser Leu 
     930                935                940
Glu Trp Glu Lys Thr Thr Asn Ser Ser Glu Pro Glu 
 945                950                955



<210> 8021
<211> 1178
<212> DNA
<213> Rattus norvegicus
<308> U08290
<400> 8021

gcgaaccct  gctctcgac  acccaccca  tttcggaac  atggccgca  tggcagcag  60
ctcggcaga  ctgctcatc  tcggctggt  catcttccg  gtgctgctg  aggtgttcc  120
ggaatgctg  atttactgg  taggattcg  ttttcgaaa  cctccaggg  cacagccca  180
tgcgagaag  gaggtgttc  ggtactccc  gcagaagct  gcgcacacg  tgtcccgga  240
cgggcggca  gtgctgggg  agcgcaggc  ccgagcccc  aactgaggc  ccatctccc  300
gccctgggc  gccgtgtca  caggtgctc  tgtgcttct  gaccagcat  ggagccaat  360
ccgcgcagg  atggggggt  ccctgtgct  cctcgtcag  ggagcactt  ccaaggtca  420
tgaggggcc  gtaggtccc  agaaaagca  caccgacaa  gatgaagac  tcagttcct  480
tcccagccc  ccccccctt  gcccctgtc  catggccgg  gggtgggag  ggatggggg  540
agaggggag  aaccctcga  atatgggcg  aggcaccac  ttctgatct  gaccaagtt  600
gaacagcac  atctcagcc  cacagatcc  accatggag  gctaacacc  caccaacca  660
cagaatgga  attctgaca  caccagctg  aaccctgaa  ctcggtgca  aagagaaag  720
gtcaactgc  tgcagcact  ggggagtgg  gggtgtggg  ggtggagga  gagggttaa  780
aaaactagt  gggccctct  gctgtccct  gcctatggc  cgcatattc  tgccttgct  840
cctcactcc  cctctcccc  gccttccaa  gccccaccc  ccaaaaatg  gtcacttga  900
tcggaccta  tcaaccagt  attggatcc  acctttacc  aaacaccgt  tctgacccc  960
ggcccttca  tgatcttgc  tatccctgg  ctcacgcag  agttgtggt  gctattgtg  1020
tagtcgcta  ttgtactag  ttacgtgtg  attagttgt  tctccccgg  tagattgta  1080
gctcctgga  acagggacc  cctccacaa  aaataaaaa  acggacctc  cctgtcttg  1140
agtgtgcta  gaccctgca  ggcagtggg  gtgcacca  1178



<210> 8022
<211> 81
<212> PRT
<213> Rattus norvegicus
<308> Q62649
<400> 8022

Met Ala Ala Val Ala Ala Ala Ser Ala Glu Leu Leu Ile Ile Gly Trp 
  1               5                  10                  15
Tyr Ile Phe Arg Val Leu Leu Gln Val Phe Leu Glu Cys Cys Ile Tyr 
             20                  25                  30
Trp Val Gly Phe Ala Phe Arg Asn Pro Pro Gly Thr Gln Pro Ile Ala 
         35                  40                  45
Arg Ser Glu Val Phe Arg Tyr Ser Leu Gln Lys Leu Ala His Thr Val 
     50                  55                  60
Ser Arg Thr Gly Arg Gln Val Leu Gly Glu Arg Arg His Arg Ala Pro 
 65                  70                  75                  80
Asn 
                 85



<210> 8023
<211> 1212
<212> DNA
<213> Homo sapiens
<308> AB002392
<400> 8023

accctcttt  tcgaccacc  acctaccat  cttggaacc  tggcggcag  ggcggcggc  60
tcggctgaa  tgctcatca  cggctggta  atcttccgc  tgctgctgc  ggtgttcct  120
gaatgctgc  tttactggg  aggattcgc  tttcgaaat  ctccaggga  acagcccat  180
gcgagaagt  aggtgttca  gtactccct  cagaagctg  catacacgg  gtcgcggac  240
gggcggcag  tgttggggg  gcgcaggca  cgagccccc  actgaggcc  cagctccca  300
ccctgggcg  ccgtatcat  aggtgctcc  gtgcatctc  gccagcacg  gagccagtg  360
cgcgcagga  tgtggggtc  cctgtgttc  ctcgccaga  gagcacttg  caaggtcag  420
gaggggcca  tagaccccc  gagaagcag  accgacaat  acgaagata  cagatccct  480
cccaacccc  ttgcaccgg  cccactaag  ggcagggtc  agagaggag  ggggatagg  540
ggagcagac  cctgagatc  gggcatagg  accgcattc  gatctggac  aagtcggga  600
agcaccatc  cagccccga  gccagggcc  tgccagcag  ccccaccat  gaaatcaaa  660
caccgcacc  gccagcaga  tggacattc  gacatcgcc  gccgacgcc  tgaatcttg  720
tgcagcacc  accgcgtgc  tgtgtggcg  gactggagg  cacagttga  gaaggaggg  780
ggttaagaa  tacagtggg  ccctctcgc  gtcccttgc  cagggcact  gcattccag  840
ctcgctgca  ttgctctct  gattcccct  tcctcctca  tgcctccca  gcccaccct  900
ctccaaaat  atgtgtcac  tgatttgga  ctattcaag  agtaaaagt  aatgaatcc  960
acctttact  aaacacttt  tctgaaccc  ccttgcccc  cactgatct  gcttttccc  1020
ggtctcatg  agttgtggt  aatattgtg  taatcgcta  ttgtactga  tgtttaagt  1080
tgcattagt  gtgtctccc  agctagatt  taagctcct  gaggacagg  accacctct  1140
caaaaaata  aaaaagtac  tcccctgtc  cgcacagtg  cccaggacc  tgcggtgca  1200
tagaggcgc  cc  1212



<210> 8024
<211> 81
<212> PRT
<213> Homo sapiens
<308> Q16517
<400> 8024

Met Ala Ala Val Ala Ala Ala Ser Ala Glu Leu Leu Ile Ile Gly Trp 
  1               5                  10                  15
Tyr Ile Phe Arg Val Leu Leu Gln Val Phe Leu Glu Cys Cys Ile Tyr 
             20                  25                  30
Trp Val Gly Phe Ala Phe Arg Asn Pro Pro Gly Thr Gln Pro Ile Ala 
         35                  40                  45
Arg Ser Glu Val Phe Arg Tyr Ser Leu Gln Lys Leu Ala Tyr Thr Val 
     50                  55                  60
Ser Arg Thr Gly Arg Gln Val Leu Gly Glu Arg Arg Gln Arg Ala Pro 
 65                  70                  75                  80
Asn 
                 85



<210> 8025
<211> 1097
<212> DNA
<213> Rattus norvegicus
<308> U08976
<400> 8025

agctccaga  atggctacc  cgatgacag  ttccagcaa  ctcctcggc  tgctgatgc  60
gcagctgag  ggtacccgc  agctgtact  caacgtcag  cttcgatct  tgagctcct  120
tgcacaaga  gcgtccaaa  gaatccctg  ggaagtctc  gaccacaac  acgagtcta  180
tcaagtaac  tctgcccag  agcatgttc  gcatgtaca  ctaaaccgg  cggagaaga  240
gaatgccat  aacagggct  tctggaggg  gttggtgga  tgcttccaa  agatatcta  300
agactccga  tgtcgggct  ttgtggtct  tggtgcagg  aagatgttc  cttcaggta  360
tgacctcat  gacatggca  cagacatcc  gcagccccc  ggagacgat  tggcccgca  420
agcctggta  ctccgagac  tcatcagcc  ataccaaaa  actttcact  tcattgaga  480
gtgccccaa  ccggtgatc  ccgcaattc  cggaggctg  attggtgga  gcgtggatc  540
tatttctgc  tgtgacatt  gctactgca  tcaggatgc  ttcttccaa  tcaaggagg  600
ggatgtggg  ctggctgct  atgtaggaa  gctgcagcg  ctgcccaag  tcattggga  660
ccggagcct  gtcaacgag  tgaccttca  cgcccgcaa  atgatggct  acgaggccc  720
ggacagtgg  ctggtcagc  gcgtgttcc  agataagga  gtcatgctg  atgcagcct  780
tgccctggc  gccgatatt  ccagcaaga  tcctgtggc  gtgcagggg  caaaaatca  840
tttaatcta  tcccgagac  attctgtgg  cgagagcct  gactatatg  ccacttgga  900
catgagcat  ctgcagacc  aggacatca  caagtcagt  caggcagcc  tggagaaga  960
ggactcaaa  agcatcacc  tctccaagc  ctgagtgcc  tcctgaccc  ggtcccctc  1020
gtgcctcct  ccggtgtat  actttatga  ttagttctt  agttcccgg  gccttatct  1080
cactgtgaa  aataaag  1097



<210> 8026
<211> 327
<212> PRT
<213> Rattus norvegicus
<308> Q62651
<400> 8026

Met Ala Thr Ala Met Thr Val Ser Ser Lys Leu Leu Gly Leu Leu Met 
  1               5                  10                  15
Gln Gln Leu Arg Gly Thr Arg Gln Leu Tyr Phe Asn Val Ser Leu Arg 
             20                  25                  30
Ser Leu Ser Ser Ser Ala Gln Glu Ala Ser Lys Arg Ile Pro Glu Glu 
         35                  40                  45
Val Ser Asp His Asn Tyr Glu Ser Ile Gln Val Thr Ser Ala Gln Lys 
     50                  55                  60
His Val Leu His Val Gln Leu Asn Arg Pro Glu Lys Arg Asn Ala Met 
 65                  70                  75                  80
Asn Arg Ala Phe Trp Arg Glu Leu Val Glu Cys Phe Gln Lys Ile Ser 
                 85                  90                  95
Lys Asp Ser Asp Cys Arg Ala Val Val Val Ser Gly Ala Gly Lys Met 
             100                105                110
Phe Thr Ser Gly Ile Asp Leu Met Asp Met Ala Ser Asp Ile Leu Gln 
         115                120                125
Pro Pro Gly Asp Asp Val Ala Arg Ile Ala Trp Tyr Leu Arg Asp Leu 
     130                135                140
Ile Ser Arg Tyr Gln Lys Thr Phe Thr Val Ile Glu Lys Cys Pro Lys 
 145                150                155                160
Pro Val Ile Ala Ala Ile His Gly Gly Cys Ile Gly Gly Gly Val Asp 
                 165                170                175
Leu Ile Ser Ala Cys Asp Ile Arg Tyr Cys Thr Gln Asp Ala Phe Phe 
             180                185                190
Gln Val Lys Glu Val Asp Val Gly Leu Ala Ala Asp Val Gly Thr Leu 
         195                200                205
Gln Arg Leu Pro Lys Val Ile Gly Asn Arg Ser Leu Val Asn Glu Leu 
     210                215                220
Thr Phe Thr Ala Arg Lys Met Met Ala Asp Glu Ala Leu Asp Ser Gly 
 225                230                235                240
Leu Val Ser Arg Val Phe Pro Asp Lys Asp Val Met Leu Asn Ala Ala 
                 245                250                255
Phe Ala Leu Ala Ala Asp Ile Ser Ser Lys Ser Pro Val Ala Val Gln 
             260                265                270
Gly Ser Lys Ile Asn Leu Ile Tyr Ser Arg Asp His Ser Val Asp Glu 
         275                280                285
Ser Leu Asp Tyr Met Ala Thr Trp Asn Met Ser Met Leu Gln Thr Gln 
     290                295                300
Asp Ile Ile Lys Ser Val Gln Ala Ala Met Glu Lys Lys Asp Ser Lys 
 305                310                315                320
Ser Ile Thr Phe Ser Lys Leu 
                 325



<210> 8027
<211> 1196
<212> DNA
<213> Homo sapiens
<308> U16660
<400> 8027

ggaactcag  agacgaagg  ggcggcgat  gcggcgggg  tagtggctt  tcgcagact  60
cgcgaccta  tgacccggc  actgacagg  tccaactac  cgggactca  tattagcct  120
cgcctcact  gctcctctg  acaagagga  gcttccgga  tagccctcg  tgaagcccc  180
gaccacagc  atgagtccc  tcgtgtgac  tctgcgcag  aacatgttc  gcatgtcca  240
ctcaaccgg  ccaacaaga  gaatgccat  aacaaggtc  tctggagag  gatggtaga  300
tgcttcaac  agatttcga  agacgctga  tgtcgggcg  tggtgatct  tggtgcagg  360
aaaatgttc  ctgcaggta  tgacctgat  gacatggct  cggacatcc  gcagcccaa  420
ggagatgat  tggcccgga  cagctggta  ctccgtgac  tcatcactc  ataccagga  480
accttcaac  tcatcgaga  gtgccccaa  cccgtgatt  ctgccgtcc  tgggggctg  540
attggcgga  gtgtggacc  tgtcaccgc  tgtgacatc  ggtactgtg  ccaggatgc  600
ttcttccag  tgaaggagg  ggacgtggg  ttggctgcc  atgtaggaa  actggagcg  660
ctgcccaag  tcatcggga  ccagagcct  gtcaacgag  tggccttca  cgcccacaa  720
atgatggct  acgaggccc  ggacagtgg  ctggtcagc  gggtgttcc  agacaaaga  780
gtcatgctg  atgctgcct  acccctggc  cccgagatt  ccagcaaga  caccgtgtt  840
gtgcagagc  ccaaggtca  cctgctgta  tcccgcgac  attcggtgg  cgagagcct  900
aactacgtg  cgtcctgga  catgagcat  ctgcagacc  aagacctcg  gaagtcggt  960
cagcccacg  ctgagaaca  ggaactgaa  accgtcacc  tctccaagc  ctgagagcc  1020
tcgcgtccc  gccccagcc  gggggccgg  cttgtcccg  ctcatccac  gaaagggag  1080
atgggcgat  acagttgtt  ctatgcctt  tgacccagt  tcccagttt  taactttat  1140
acaatgagt  tctcaagcc  aaggcctta  cttcacccc  caaacaata  agcaaa  1196



<210> 8028
<211> 328
<212> PRT
<213> Homo sapiens
<308> Q13011
<400> 8028

Met Ala Ala Gly Ile Val Ala Ser Arg Arg Leu Arg Asp Leu Leu Thr 
  1               5                  10                  15
Arg Arg Leu Thr Gly Ser Asn Tyr Pro Gly Leu Ser Ile Ser Leu Arg 
             20                  25                  30
Leu Thr Gly Ser Ser Ala Gln Glu Glu Ala Ser Gly Val Ala Leu Gly 
         35                  40                  45
Glu Ala Pro Asp His Ser Tyr Glu Ser Leu Arg Val Thr Ser Ala Gln 
     50                  55                  60
Lys His Val Leu His Val Gln Leu Asn Arg Pro Asn Lys Arg Asn Ala 
 65                  70                  75                  80
Met Asn Lys Val Phe Trp Arg Glu Met Val Glu Cys Phe Asn Lys Ile 
                 85                  90                  95
Ser Arg Asp Ala Asp Cys Arg Ala Val Val Ile Ser Gly Ala Gly Lys 
             100                105                110
Met Phe Thr Ala Gly Ile Asp Leu Met Asp Met Ala Ser Asp Ile Leu 
         115                120                125
Gln Pro Lys Gly Asp Asp Val Ala Arg Ile Ser Trp Tyr Leu Arg Asp 
     130                135                140
Ile Ile Thr Arg Tyr Gln Glu Thr Phe Asn Val Ile Glu Arg Cys Pro 
 145                150                155                160
Lys Pro Val Ile Ala Ala Val His Gly Gly Cys Ile Gly Gly Gly Val 
                 165                170                175
Asp Leu Val Thr Ala Cys Asp Ile Arg Tyr Cys Ala Gln Asp Ala Phe 
             180                185                190
Phe Gln Val Lys Glu Val Asp Val Gly Leu Ala Ala Asp Val Gly Thr 
         195                200                205
Leu Glu Arg Leu Pro Lys Val Ile Gly Asn Gln Ser Leu Val Asn Glu 
     210                215                220
Leu Ala Phe Thr Ala His Lys Met Met Ala Asp Glu Ala Leu Asp Ser 
 225                230                235                240
Gly Leu Val Ser Arg Val Phe Pro Asp Lys Glu Val Met Leu Asp Ala 
                 245                250                255
Ala Leu Pro Leu Ala Pro Glu Ile Ser Ser Lys Thr Thr Val Leu Val 
             260                265                270
Gln Ser Thr Lys Val Asn Leu Leu Tyr Ser Arg Asp His Ser Val Ala 
         275                280                285
Glu Ser Leu Asn Tyr Val Ala Ser Trp Asn Met Ser Met Leu Gln Thr 
     290                295                300
Gln Asp Leu Val Lys Ser Val Gln Pro Thr Thr Glu Asn Lys Glu Leu 
 305                310                315                320
Lys Thr Val Thr Phe Ser Lys Leu 
                 325



<210> 8029
<211> 2858
<212> DNA
<213> Rattus norvegicus
<308> U09211
<400> 8029

ggcagcgcg  ctcacctcg  gggctccgt  cccgctgtg  gccgaagtc  aggctgagg  60
ggaggtcta  agcccccgg  tctcccgtc  cccaccagg  tgcggggaa  tggctgccg  120
acccctcct  caagtgggg  tagaacgga  tctcacccc  ataggtccc  gaactaagg  180
gaacatagg  ccggttcct  ccactgctc  gccatcccc  ggggcttgt  taggactat  240
gctctccaa  tcccccttc  cctggcttc  atcctgggc  catctcaga  gcggacccc  300
gcccggacg  gccccgccc  cggcccccg  cccgacgac  tcctattag  atgagcgac  360
ccagtggcc  gggcaccac  cgggggccg  gactcaccg  gtcatagcc  caagtggag  420
gagaaagaa  aaaaaagag  cggcggtgg  ggaagaggc  agagcggac  cgcggggag  480
gctggagag  cggcgggcg  cggcagcat  cccctgggc  ggtgcacac  gcctctctg  540
accgcaggg  ctgcttctg  tctctctgg  caccacgcg  ccagtctcc  gcctcagcc  600
ctcggcttg  cggcctttg  ggttgcgct  gaaacatcg  ccactggtc  ccgaagcat  660
taagagcag  ggcgccgcg  gggacaatc  ttgcttttt  ctgagctcg  ggatatgag  720
cccacagcc  cctgaagcg  agggggcgc  acgcggcta  gaccgcgcc  ccgaagtac  780
ttatcctag  ctctgcact  cgggacgcc  acacccgac  ccggtggag  catcttagg  840
aaagcagcc  gtaggggca  ggaacccac  gcgccaacc  gtcaggccc  ggcggcggc  900
accaaactg  cggaagcgg  gggagccgc  ctacaagag  cccagaggc  gcggcgcct  960
gtgctggtc  tcgtgtgcg  tgcactgtt  ctggacaac  tgttgtaca  ggtcatcgt  1020
cccattgtt  ccgactata  cgcccacat  cgcgggggc  gcgagggcc  gaccctggt  1080
tctgaggtg  gggaaccca  tctgccgcc  cccactctg  ctaatgcca  tgcctactt  1140
gccaacacg  cggcgtccc  gacggctgc  gggtcggct  ggtcaatcc  gcgacctcg  1200
taccccaca  aaagcgaag  tgtgaagat  ggtgtgctg  ttgcctcca  ggctatcct  1260
cagcttctg  tgaacccct  aagcgggcc  ttcattgat  gcatgagct  cgacgtgcc  1320
ctgcttata  gcctgggcg  catgttcgc  tccacagtc  tgtttgcct  tgcagaaga  1380
tatgccacg  tcttcgctg  gcgcagtct  caaggcctg  gctcggcct  cgcggacac  1440
tctggcatt  ccatgatcg  cgacaagta  cccgaggag  ctgagcgca  tcgtgccct  1500
ggcgtggcg  tagccttta  tagctttgg  agcctagtg  cgccaccgt  tgggggcat  1560
ctctacgag  tcgcgggca  gcgtgtacc  tttctagtg  tcgccgctg  gtccctttt  1620
gacgcgctc  tgctcctgg  ggtggctaa  cccttctcg  ctgcggctc  ggcgcgagc  1680
aacctgccg  tgggcacac  tatccatcg  ctcatgcta  acccttaca  cgctgtggt  1740
gccggcgcg  tcaccactt  taacattcc  cttgcgttc  tcgagccca  catagccac  1800
tggatgaag  acacaatgg  cgcatccga  tgggagatg  gcatggttt  gctgccggc  1860
ttcgtgcca  acgtgttag  cgtctacct  accgtgcgc  tggcggcgc  ttatccaca  1920
ctgcagtgg  tgtacggcg  tctcgggct  gcggtaatt  gagtgagct  ttgcgtcgt  1980
cctgcctgt  gctcattcg  gccgttagt  gtctcgctc  gcggactct  cttcggcat  2040
gcgttagtg  acacagcgc  cctacccac  ctcgccttt  tggtggacg  gcgccacgt  2100
tccgtctat  gcagtgtct  tgccatagc  gacatctcc  attctgtgg  ctacgcgct  2160
gggcccata  tggcaggcc  catcgttca  tctcttggc  ttgagcagc  cagcctggg  2220
atgggcctg  ccaacctgc  ctacgcacc  gtccttctt  ttttgcgca  tgtaggcct  2280
cttacacgc  cgcgttcgg  gcgcgatgt  ttgcttgat  aaccgccgc  gggtctgta  2340
gacgcggtg  gcctgcgtg  ggtgcaggg  aaggatggc  gcgaacctt  tagcccacc  2400
ggccctttt  acgggtgcg  ggacgacta  aactattac  cccgcagct  gcagacccg  2460
ttctcctcc  ggccaccta  ccgccccat  taggtcaag  tggtcattc  gcaagagca  2520
tgtccaact  tggcttggg  cccacctcc  ctaatgaat  ccctagccc  tcgcccgtc  2580
tgaattcct  tgctggaat  ccttctcca  gacccctcc  agtctaggc  cctccccaa  2640
cacactcgt  ttcattggg  aaatggagc  gggaggcag  agaagctgt  gggctcttg  2700
cagaggtga  gaggtgtgc  ggtgatcgc  aatcaccta  tgagagccc  caaatagag  2760
catgcatct  tttgtcctt  ctgcggatc  ttccagtgc  aaacttggt  tctgcactc  2820
ggtgcctcc  gcctgaatt  ataaaccat  tctatctg  2858



<210> 8030
<211> 530
<212> PRT
<213> Rattus norvegicus
<308> AAA20498
<400> 8030

Met Glu Pro Thr Ala Pro Thr Gly Gln Ala Arg Ala Ala Ala Thr Lys 
  1               5                  10                  15
Leu Ser Glu Ala Val Gly Ala Ala Leu Gln Glu Pro Gln Arg Gln Arg 
             20                  25                  30
Arg Leu Val Leu Val Ile Val Cys Val Ala Leu Leu Leu Asp Asn Met 
         35                  40                  45
Leu Tyr Met Val Ile Val Pro Ile Val Pro Asp Tyr Ile Ala His Met 
     50                  55                  60
Arg Gly Gly Ser Glu Gly Pro Thr Leu Val Ser Glu Val Trp Glu Pro 
 65                  70                  75                  80
Thr Leu Pro Pro Pro Thr Leu Ala Asn Ala Ser Thr Tyr Leu Ala Asn 
                 85                  90                  95
Thr Ser Ala Ser Pro Thr Ala Ala Gly Ser Ala Arg Ser Ile Leu Arg 
             100                105                110
Pro Arg Tyr Pro Thr Glu Ser Glu Asp Val Lys Ile Gly Val Leu Phe 
         115                120                125
Ala Ser Lys Ala Ile Leu Gln Leu Leu Val Asn Pro Leu Ser Gly Pro 
     130                135                140
Phe Ile Asp Arg Met Ser Tyr Asp Val Pro Leu Leu Ile Gly Leu Gly 
 145                150                155                160
Val Met Phe Ala Ser Thr Val Met Phe Ala Phe Ala Glu Asp Tyr Ala 
                 165                170                175
Thr Leu Phe Ala Ala Arg Ser Leu Gln Gly Leu Gly Ser Ala Phe Ala 
             180                185                190
Asp Thr Ser Gly Ile Ala Met Ile Ala Asp Lys Tyr Pro Glu Glu Pro 
         195                200                205
Glu Arg Ser Arg Ala Leu Gly Val Ala Leu Ala Phe Ile Ser Phe Gly 
     210                215                220
Ser Leu Val Ala Pro Pro Phe Gly Gly Ile Leu Tyr Glu Phe Ala Gly 
 225                230                235                240
Lys Arg Val Pro Phe Leu Val Leu Ala Ala Val Ser Leu Phe Asp Ala 
                 245                250                255
Leu Leu Leu Leu Ala Val Ala Lys Pro Phe Ser Ala Ala Ala Arg Ala 
             260                265                270
Arg Ala Asn Leu Pro Val Gly Thr Pro Ile His Arg Leu Met Leu Asp 
         275                280                285
Pro Tyr Ile Ala Val Val Ala Gly Ala Leu Thr Thr Cys Asn Ile Pro 
     290                295                300
Leu Ala Phe Leu Glu Pro Thr Ile Ala Thr Trp Met Lys His Thr Met 
 305                310                315                320
Ala Ala Ser Glu Trp Glu Met Gly Met Val Trp Leu Pro Ala Phe Val 
                 325                330                335
Pro His Val Leu Gly Val Tyr Leu Thr Val Arg Leu Ala Ala Arg Tyr 
             340                345                350
Pro His Leu Gln Trp Leu Tyr Gly Ala Leu Gly Leu Ala Val Ile Gly 
         355                360                365
Val Ser Ser Cys Val Val Pro Ala Cys Arg Ser Phe Ala Pro Leu Val 
     370                375                380
Val Ser Leu Cys Gly Leu Cys Phe Gly Ile Ala Leu Val Asp Thr Ala 
 385                390                395                400
Leu Leu Pro Thr Leu Ala Phe Leu Val Asp Val Arg His Val Ser Val 
                 405                410                415
Tyr Gly Ser Val Tyr Ala Ile Ala Asp Ile Ser Tyr Ser Val Ala Tyr 
             420                425                430
Ala Leu Gly Pro Ile Val Ala Gly His Ile Val His Ser Leu Gly Phe 
         435                440                445
Glu Gln Leu Ser Leu Gly Met Gly Leu Ala Asn Leu Leu Tyr Ala Pro 
     450                455                460
Val Leu Leu Leu Leu Arg Asn Val Gly Leu Leu Thr Arg Ser Arg Ser 
 465                470                475                480
Glu Arg Asp Val Leu Leu Asp Glu Pro Pro Gln Gly Leu Tyr Asp Ala 
                 485                490                495
Val Arg Leu Arg Glu Val Gln Gly Lys Asp Gly Gly Glu Pro Cys Ser 
             500                505                510
Pro Pro Gly Pro Phe Asp Gly Cys Glu Asp Asp Tyr Asn Tyr Tyr Ser 
         515                520                525
Arg Ser 
     530



<210> 8031
<211> 2421
<212> DNA
<213> Homo sapiens
<308> U09210
<400> 8031

ggaggaggc  agagccgac  cgaggggag  ggagcgcag  ggcggggct  acgggcggg  60
aagcgggcg  gcggcaaca  catgtccct  ggccagcgc  ggcggcctc  tagcgcggc  120
ggggctgct  tgggcgcgc  ccgggcgaa  tgcgcccag  ctccggccc  ggcccctcg  180
cgcgcccga  ttcccggcc  cccctgagc  cagcagccg  gggtcccgg  atcggctaa  240
agtagctgc  acgcctcgc  ggacggagt  ctttccttt  ccgggacgc  gggccatga  300
ctccgcggc  cacctgagg  acaggggag  ctgctcggc  aggacagcc  ccccgaagt  360
ccgctgccc  cgcctctgc  ctgcgggac  ccagcgctc  gccctggcg  aggcgtctt  420
ggaagagca  cggggtggg  gcatggaat  cgcggaacc  gcgggccag  cccgggcgg  480
ggccaccaa  ctgtcggag  ctgtgggcg  ggcgctgca  gagccccgg  ggcagaggc  540
cctggtgct  gttatcgtg  gcgtggcgc  gttactgga  aacatgctg  acatggtca  600
cgtgcccat  gtgcccgac  acatcgccc  catgcgcgg  ggcggcgag  gccccaccc  660
gactcccga  gtgtgggag  ccaccctgc  gctgcccac  ccggccaat  ccagcgcct  720
cacggccaa  acctcggcg  ccccgacag  tgcgtggcc  gcgggctca  cccttcggc  780
ccgctaccc  acggagagc  aagacgtga  gatcggggt  ctgtttgct  ccaaggcta  840
cctgcagct  ctagtgaac  ccttgagcg  gcccttcat  gaccgcatg  gctacgacg  900
gccgctgct  atcggcctg  gcgtcatgt  cgcctctac  gtcctgttc  ccttcgccg  960
ggactacgc  acgctgttc  cggcgcgca  cctgcaggg  ctgggctca  ccttcgccg  1020
cacgtctgg  atagccatg  tcgccgata  gtacccgga  gagccggag  gcagtcgtg  1080
actgggcgt  gcgctggcc  tcattagct  cggaagcct  gtggccccg  ccttcgggg  1140
catcctcta  gagttcgcc  gcaagcgcg  gcccttctt  gtgctagct  ccgtgtcgc  1200
ctttgacgc  ctgttgctg  tggcagtgg  caaaccctt  tcggcggct  cacgggctc  1260
ggccaacct  ccagtgggc  ctcccatcc  ccgcctcat  ctagacccc  acattgccg  1320
ggtggccgg  gcgctcacc  cctgtaaca  tcccctcgc  ttcctcgaa  ccaccattg  1380
cacgtggat  aagcatacg  tggcggctt  cgagtggga  atgggcatg  cctggctgc  1440
ggccttcgt  cctcatgtg  tgggcgtct  cctcaccgt  cgcctggcg  cgcgctacc  1500
acacctgca  tggctgtac  gcgcgcttg  gctggctgt  atcggcgcc  gctcgtgca  1560
cgtgcccgc  tgccgctcc  tcgcgccgc  agtggtctc  ctatgcggc  tctgttttg  1620
catagccct  gtcgacaca  cactgctgc  cacgctcgc  ttcctggtg  acgtgcgcc  1680
tgtctcagt  tatggcagc  tctacgcca  cgccgacat  tcctattcg  tggcctacg  1740
gctcgggcc  atagtggca  gccacattg  gcactcgct  ggctttgag  agctcagcc  1800
tggcatggg  ctggccaac  tgctctatg  tcccgtctt  ctgctgctc  gcaacgtgg  1860
cctcctgac  cgctcccgt  ccgagcgcg  tgtgctgct  gatgagcca  cgcaaggtc  1920
gtacgatgc  gtgcgcctg  gtgagcgtc  tgtgtctgg  caggacggc  agcctcgca  1980
cccgcctgg  ccttttgat  agtgcgagg  cgactacaa  tactactac  cccgcagct  2040
gcatcccca  tcctcctcc  gcccaccca  ccgccttgg  tcaaggggg  tgctctgca  2100
gcccactgg  cagctctgg  tcagggccc  cctcctcca  cgagtaccc  agccactcc  2160
caaccttga  ttctgccca  atcccctcc  tgtgacccg  tccatatcc  tttctctct  2220
gtccaatgg  gcttggagc  ccgaggcca  cgaagccat  gcgctcctt  cggaggtga  2280
gaggaccct  agtccccac  tgcggctcc  ctgtgtaga  cctgcatct  tctgtcctt  2340
cttccattg  tcccagtgc  aaacttggg  cgctgcacc  cggcgcctc  gcccaaatc  2400
ataaactgt  tctgtccca  g  2421



<210> 8032
<211> 532
<212> PRT
<213> Homo sapiens
<308> NP_003046
<400> 8032

Met Glu Ser Ala Glu Pro Ala Gly Gln Ala Arg Ala Ala Ala Thr Lys 
  1               5                  10                  15
Leu Ser Glu Ala Val Gly Ala Ala Leu Gln Glu Pro Arg Arg Gln Arg 
             20                  25                  30
Arg Leu Val Leu Val Ile Val Cys Val Ala Leu Leu Leu Asp Asn Met 
         35                  40                  45
Leu Tyr Met Val Ile Val Pro Ile Val Pro Asp Tyr Ile Ala His Met 
     50                  55                  60
Arg Gly Gly Gly Glu Gly Pro Thr Arg Thr Pro Glu Val Trp Glu Pro 
 65                  70                  75                  80
Thr Leu Pro Leu Pro Thr Pro Ala Asn Ala Ser Ala Tyr Thr Ala Asn 
                 85                  90                  95
Thr Ser Ala Ser Pro Thr Ala Ala Trp Pro Ala Gly Ser Ala Leu Arg 
             100                105                110
Pro Arg Tyr Pro Thr Glu Ser Glu Asp Val Lys Ile Gly Val Leu Phe 
         115                120                125
Ala Ser Lys Ala Ile Leu Gln Leu Leu Val Asn Pro Leu Ser Gly Pro 
     130                135                140
Phe Ile Asp Arg Met Ser Tyr Asp Val Pro Leu Leu Ile Gly Leu Gly 
 145                150                155                160
Val Met Phe Ala Ser Thr Val Leu Phe Ala Phe Ala Glu Asp Tyr Ala 
                 165                170                175
Thr Leu Phe Ala Ala Arg Ser Leu Gln Gly Leu Gly Ser Ala Phe Ala 
             180                185                190
Asp Thr Ser Gly Ile Ala Met Ile Ala Asp Lys Tyr Pro Glu Glu Pro 
         195                200                205
Glu Arg Ser Arg Ala Leu Gly Val Ala Leu Ala Phe Ile Ser Phe Gly 
     210                215                220
Ser Leu Val Ala Pro Pro Phe Gly Gly Ile Leu Tyr Glu Phe Ala Gly 
 225                230                235                240
Lys Arg Val Pro Phe Leu Val Leu Ala Ala Val Ser Leu Phe Asp Ala 
                 245                250                255
Leu Leu Leu Leu Ala Val Ala Lys Pro Phe Ser Ala Ala Ala Arg Ala 
             260                265                270
Arg Ala Asn Leu Pro Val Gly Thr Pro Ile His Arg Leu Met Leu Asp 
         275                280                285
Pro Tyr Ile Ala Val Val Ala Gly Ala Leu Thr Thr Cys Asn Ile Pro 
     290                295                300
Leu Ala Phe Leu Glu Pro Thr Ile Ala Thr Trp Met Lys His Thr Met 
 305                310                315                320
Ala Ala Ser Glu Trp Glu Met Gly Met Ala Trp Leu Pro Ala Phe Val 
                 325                330                335
Pro His Val Leu Gly Val Tyr Leu Thr Val Arg Leu Ala Ala Arg Tyr 
             340                345                350
Pro His Leu Gln Trp Leu Tyr Gly Ala Leu Gly Leu Ala Val Ile Gly 
         355                360                365
Ala Ser Ser Cys Ile Val Pro Ala Cys Arg Ser Phe Ala Pro Leu Val 
     370                375                380
Val Ser Leu Cys Gly Leu Cys Phe Gly Ile Ala Leu Val Asp Thr Ala 
 385                390                395                400
Leu Leu Pro Thr Leu Ala Phe Leu Val Asp Val Arg His Val Ser Val 
                 405                410                415
Tyr Gly Ser Val Tyr Ala Ile Ala Asp Ile Ser Tyr Ser Val Ala Tyr 
             420                425                430
Ala Leu Gly Pro Ile Val Ala Gly His Ile Val His Ser Leu Gly Phe 
         435                440                445
Glu Gln Leu Ser Leu Gly Met Gly Leu Ala Asn Leu Leu Tyr Ala Pro 
     450                455                460
Val Leu Leu Leu Leu Arg Asn Val Gly Leu Leu Thr Arg Ser Arg Ser 
 465                470                475                480
Glu Arg Asp Val Leu Leu Asp Glu Pro Pro Gln Gly Leu Tyr Asp Ala 
                 485                490                495
Val Arg Leu Arg Glu Arg Pro Val Ser Gly Gln Asp Gly Glu Pro Arg 
             500                505                510
Ser Pro Pro Gly Pro Phe Asp Glu Cys Glu Asp Asp Tyr Asn Tyr Tyr 
         515                520                525
Tyr Thr Arg Ser 
     530



<210> 8033
<211> 1494
<212> DNA
<213> Rattus norvegicus
<308> U09228
<400> 8033

ggcaactct  atatcccac  gtctagcag  tactgtagc  tgcatccac  tgaacgtct  60
agctatcca  cgcactcct  ggcagacat  aactccagt  ttcctccga  gtccacgtt  120
catcgaagt  gcacaaacc  ttacagcac  tcttcctgc  cacctcctg  caacggaac  180
gacagtata  tggcaaaca  aggaactgg  gcagcaggc  gctcccaga  tggagacgc  240
ctggggaaa  ccctggctt  gatctattc  cctgatcac  cgaacaaca  cttctcctc  300
aacccttca  ctcctgttg  ctcccctcc  tcactctca  caggcacag  tgtttggtc  360
cgaaacgga  gacaggcct  gtcatctcc  aattacgaa  gacccttgc  ctccttgca  420
agccgaatt  aagaccgtt  agaaagact  gacgacgcg  ttcatgttc  ccggaacca  480
gcggtgggc  catccacag  tgtgcccgg  ggccatggg  acatgcatg  gatcatcgg  540
ccctctcac  atggagcaa  gggcagtct  ggctcagga  atggaactg  ccttctctc  600
gccaacaga  attcactca  ggtcggggc  caccgtgaa  atggcgtgg  actgagagg  660
agccattct  tcctgccaa  ccaggttcc  gttccacag  ttccggtcc  gtctgcaac  720
tcccctgac  tgaacccac  ccaagaccc  tacagaggg  tgccaccag  cctccaggg  780
cagagtgtg  cttccggca  ctctgagat  aagtccgac  acgagggcg  tgagaacct  840
caggacaca  aatcttccg  ggacaagaa  ctagacgac  acaagaagg  tatcaaatc  900
attactagg  caagatcta  caataacga  gatgaggac  tgaccccgg  gcagaaggc  960
gagcgtgag  aggagcgga  gatggccaa  aacgcccgt  agcgcctga  ggtccgtga  1020
atcaacgag  ctttcaagg  gctgggccg  atggtacag  tccacctga  gagcgacaa  1080
ccccagacc  agctcctga  tctccacca  gcagtggct  tcatcctca  cctggagca  1140
caagtgcga  aaaggaacc  gaacccaaa  gctgcctgt  tgaaaagaa  ggaggaaga  1200
aaggtgtcc  cagagcctc  cccgctctc  ttggctggc  cacaccctg  gatgggaga  1260
gcagcgaat  acatgggtc  gatgtgaaa  ggtccaagt  gccaccttg  ttcattaaa  1320
caagagacc  cttccttaa  agctgtatt  tcctaaacc  acataaaca  tgctcctta  1380
ccccgtttt  tttgtaata  aagacaagt  tgagtagtt  tgaatcgca  acgcaagag  1440
tttcagcat  cccaattat  aaaaaacag  aaaacaaac  caaaaaaaa  aaaa  1494



<210> 8034
<211> 428
<212> PRT
<213> Rattus norvegicus
<308> Q62655
<400> 8034

Gly Asn Ser His Ile Pro Gln Ser Ser Ser Tyr Cys Ser Leu His Pro 
  1               5                  10                  15
His Glu Arg Leu Ser Tyr Pro Ser His Ser Ser Ala Asp Ile Asn Ser 
             20                  25                  30
Ser Leu Pro Pro Met Ser Thr Phe His Arg Ser Gly Thr Asn His Tyr 
         35                  40                  45
Ser Thr Ser Ser Cys Thr Pro Pro Ala Asn Gly Thr Asp Ser Ile Met 
     50                  55                  60
Ala Asn Arg Gly Thr Gly Ala Ala Gly Ser Ser Gln Thr Gly Asp Ala 
 65                  70                  75                  80
Leu Gly Lys Ala Leu Ala Ser Ile Tyr Ser Pro Asp His Thr Asn Asn 
                 85                  90                  95
Ser Phe Ser Ser Asn Pro Ser Thr Pro Val Gly Ser Pro Pro Ser Leu 
             100                105                110
Ser Ala Gly Thr Ala Val Trp Ser Arg Asn Gly Gly Gln Ala Ser Ser 
         115                120                125
Ser Pro Asn Tyr Glu Gly Pro Leu His Ser Leu Gln Ser Arg Ile Glu 
     130                135                140
Asp Arg Leu Glu Arg Leu Asp Asp Ala Ile His Val Leu Arg Asn His 
 145                150                155                160
Ala Val Gly Pro Ser Thr Ala Val Pro Gly Gly His Gly Asp Met His 
                 165                170                175
Gly Ile Ile Gly Pro Ser His Asn Gly Ala Met Gly Ser Leu Gly Ser 
             180                185                190
Gly Tyr Gly Thr Gly Leu Leu Ser Ala Asn Arg His Ser Leu Met Val 
         195                200                205
Gly Ala His Arg Glu Asp Gly Val Ala Leu Arg Gly Ser His Ser Leu 
     210                215                220
Leu Pro Asn Gln Val Pro Val Pro Gln Leu Pro Val Gln Ser Ala Thr 
 225                230                235                240
Ser Pro Asp Leu Asn Pro Pro Gln Asp Pro Tyr Arg Gly Met Pro Pro 
                 245                250                255
Gly Leu Gln Gly Gln Ser Val Ser Ser Gly Ser Ser Glu Ile Lys Ser 
             260                265                270
Asp Asp Glu Gly Asp Glu Asn Leu Gln Asp Thr Lys Ser Ser Glu Asp 
         275                280                285
Lys Lys Leu Asp Asp Asp Lys Lys Asp Ile Lys Ser Ile Thr Arg Ser 
     290                295                300
Arg Ser Ser Asn Asn Asp Asp Glu Asp Leu Thr Pro Glu Gln Lys Ala 
 305                310                315                320
Glu Arg Glu Lys Glu Arg Arg Met Ala Asn Asn Ala Arg Glu Arg Leu 
                 325                330                335
Arg Val Arg Asp Ile Asn Glu Ala Phe Lys Glu Leu Gly Arg Met Val 
             340                345                350
Gln Leu His Leu Lys Ser Asp Lys Pro Gln Thr Lys Leu Leu Ile Leu 
         355                360                365
His Gln Ala Val Ala Val Ile Leu Ser Leu Glu Gln Gln Val Arg Glu 
     370                375                380
Arg Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys Arg Arg Glu Glu Glu 
 385                390                395                400
Lys Val Ser Ser Glu Pro Pro Pro Leu Ser Leu Ala Gly Pro His Pro 
                 405                410                415
Gly Met Gly Asp Ala Ala Asn His Met Gly Gln Met 
             420                425



<210> 8035
<211> 1958
<212> DNA
<213> Homo sapiens
<308> AK026674
<400> 8035

agctttata  cacgtgctg  tctgccttc  tgagacaag  cgtcgtgca  acttctctt  60
tttacatga  agcccttgg  atatttgaa  cctgctgct  tgacgactt  ctcatatga  120
atgctttcc  ggtggctca  catcctctt  gccttccat  caaaagttt  taatttgtc  180
ctgtaacac  cagaaatgg  cagaaccga  cttatcttt  cagactatt  tgggcccgg  240
cgtgcattt  ttatgaatc  tggaatatt  tggttttca  aattagaaa  taccttttg  300
ctttttttt  ttttttttt  gtaagagac  gagtctggc  gtgttgccc  ggctggagt  360
cagtggcct  atcacatct  actgtagcc  ccacctcct  gattcaagt  agcctccca  420
ctcagcctc  tgagtagct  agaccgcag  tgtgcatca  tgtgcccag  taatttttt  480
ttatttttt  tagagacga  gtctcacta  atcgtccag  ctggggtta  aggcatgag  540
cactgcacc  agctttctg  cttcatttt  gactcacaa  gaggtcatg  tcattcata  600
gctgcaggt  tttggtttg  tgaatcgtt  tgcatgact  atatcagtt  aggtttccc  660
aacttgttc  gtggatcat  aacatctat  agattaaag  ccatggaag  catgttttt  720
taacttttt  tttaataca  agagaaaat  agactcaca  agtgggttg  ccaggcctt  780
aaagcaagg  aatggggac  cctgaataa  agcctcact  tcttcactc  cattgctct  840
gtgtcttac  tataggcct  tcttcttac  cctgttaag  tgccttgta  ttttttgac  900
tatcaaaat  atttttcaa  tacttgttt  ccctagatt  cagatgtca  ggtatgaaa  960
gttttatat  tatttaaaa  ataaagtat  aacataaag  ctttttgaa  cgtggttat  1020
caacatatg  taggcgtaa  ttggtgaat  cctgctttg  agagtgtaa  cccattgaa  1080
aaaaaaagc  ttgttttcc  tttctgccc  cctgtatca  tatgggcac  ccctgcact  1140
taactttaa  ctacgtcac  ctcacctgt  tggtttggg  ttaatgtct  tgagaaaac  1200
aaatatctt  tgtattgtg  actgtcaaa  ccatctaaa  caatcccaa  gtcaagtgg  1260
tataaaaat  ctgccaaaa  catggcata  gatggaaaa  ttccctgaa  actctggaa  1320
aaaacaaag  aatgtagac  ccttctttt  ccccacacc  ttagaaaat  ttgcatccc  1380
tttgtccca  agcaataat  acgatgagg  cctgacacc  gagcagaag  cagagcgtg  1440
gaaggagcg  aggatggcc  acaatgccc  agagcgtct  cgggtccgt  acatcaacg  1500
ggctttcaa  gagctcggc  gcatggtgc  gctccacct  aagagtgac  agccccaga  1560
caagctcct  atcctccac  aggcggtgg  cgtcatcct  agtctggag  agcaagtcc  1620
agaaaggaa  ctgaatccg  aagctgcgt  tctgaaaag  agggaggaa  agaaggtgt  1680
ctcggagcc  ccccctctc  ccttggccg  cccacaccc  ggaatggga  acgcatcga  1740
tcacatggg  cagatgtaa  agggtccaa  ttgccacat  gcttcatta  aacaagaga  1800
cacttcctt  acagctgta  tatcttaaa  ccacataaa  acttctcct  aacccccat  1860
tttgtaata  aagacaagt  tgagtagtt  tgaatcgca  acgcaagag  tttcagcat  1920
cccaattat  aaaaaacag  aaaacaaaa  aaaaaaaa  1958



<210> 8036
<211> 667
<212> PRT
<213> Homo sapiens
<308> AAA60310
<400> 8036

Met His His Gln Gln Arg Met Ala Ala Leu Gly Thr Asp Lys Glu Leu 
  1               5                  10                  15
Ser Asp Leu Leu Asp Phe Ser Ala Met Phe Ser Pro Pro Val Ser Ser 
             20                  25                  30
Gly Lys Asn Gly Pro Thr Ser Leu Ala Ser Gly His Phe Thr Gly Ser 
         35                  40                  45
Asn Val Glu Asp Arg Ser Ser Ser Gly Ser Trp Gly Asn Gly Gly His 
     50                  55                  60
Pro Ser Pro Ser Arg Asn Tyr Gly Asp Gly Thr Pro Tyr Asp His Met 
 65                  70                  75                  80
Thr Ser Arg Asp Leu Gly Ser His Asp Asn Leu Ser Pro Pro Phe Val 
                 85                  90                  95
Asn Ser Arg Ile Gln Ser Lys Thr Glu Arg Gly Ser Tyr Ser Ser Tyr 
             100                105                110
Gly Arg Glu Ser Asn Leu Gln Gly Cys His Gln Gln Ser Leu Leu Gly 
         115                120                125
Gly Asp Met Asp Met Gly Asn Pro Gly Thr Leu Ser Pro Thr Lys Pro 
     130                135                140
Gly Ser Gln Tyr Tyr Gln Tyr Ser Ser Asn Asn Pro Arg Arg Arg Pro 
 145                150                155                160
Leu His Ser Ser Ala Met Glu Val Gln Thr Lys Lys Val Arg Lys Val 
                 165                170                175
Pro Pro Gly Leu Pro Ser Ser Val Tyr Ala Pro Ser Ala Ser Thr Ala 
             180                185                190
Asp Tyr Asn Arg Asp Ser Pro Gly Tyr Pro Ser Ser Lys Pro Ala Thr 
         195                200                205
Ser Thr Phe Pro Ser Ser Phe Phe Met Gln Asp Gly His His Ser Ser 
     210                215                220
Asp Pro Trp Ser Ser Ser Ser Gly Met Asn Gln Pro Gly Tyr Ala Gly 
 225                230                235                240
Met Leu Gly Asn Ser Ser His Ile Pro Gln Ser Ser Ser Tyr Cys Ser 
                 245                250                255
Leu His Pro His Glu Arg Leu Ser Tyr Pro Ser His Ser Ser Ala Asp 
             260                265                270
Ile Asn Ser Ser Leu Pro Pro Met Ser Thr Phe His Arg Ser Gly Thr 
         275                280                285
Asn His Tyr Ser Thr Ser Ser Cys Thr Pro Pro Ala Asn Gly Thr Asp 
     290                295                300
Ser Ile Met Ala Asn Arg Gly Ser Gly Ala Ala Gly Ser Ser Gln Thr 
 305                310                315                320
Gly Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr Ser Pro Asp His 
                 325                330                335
Thr Asn Asn Ser Phe Ser Ser Asn Pro Ser Thr Pro Val Gly Ser Pro 
             340                345                350
Pro Ser Leu Ser Ala Gly Thr Ala Val Trp Ser Arg Asn Gly Gly Gln 
         355                360                365
Ala Ser Ser Ser Pro Asn Tyr Glu Gly Pro Leu His Ser Leu Gln Ser 
     370                375                380
Arg Ile Glu Asp Arg Leu Glu Arg Leu Asp Asp Ala Ile His Val Leu 
 385                390                395                400
Arg Asn His Ala Val Gly Pro Ser Thr Ala Met Pro Gly Gly His Gly 
                 405                410                415
Asp Met His Gly Ile Ile Gly Pro Ser His Asn Gly Ala Met Gly Gly 
             420                425                430
Leu Gly Ser Gly Tyr Gly Thr Gly Leu Leu Ser Ala Asn Arg His Ser 
         435                440                445
Leu Met Val Gly Thr His Arg Glu Asp Gly Val Ala Leu Arg Gly Ser 
     450                455                460
His Ser Leu Leu Pro Asn Gln Val Pro Val Pro Gln Leu Pro Val Gln 
 465                470                475                480
Ser Ala Thr Ser Pro Asp Leu Asn Pro Pro Gln Asp Pro Tyr Arg Gly 
                 485                490                495
Met Pro Pro Gly Leu Gln Gly Gln Ser Val Ser Ser Gly Ser Ser Glu 
             500                505                510
Ile Lys Ser Asp Asp Glu Gly Asp Glu Asn Leu Gln Asp Thr Lys Ser 
         515                520                525
Ser Glu Asp Lys Lys Leu Asp Asp Asp Lys Lys Asp Ile Lys Ser Ile 
     530                535                540
Thr Ser Asn Asn Asp Asp Glu Asp Leu Thr Pro Glu Gln Lys Ala Glu 
 545                550                555                560
Arg Glu Lys Glu Arg Arg Met Ala Asn Asn Ala Arg Glu Arg Leu Arg 
                 565                570                575
Val Arg Asp Ile Asn Glu Ala Phe Lys Glu Leu Gly Arg Met Val Gln 
             580                585                590
Leu His Leu Lys Ser Asp Lys Pro Gln Thr Lys Leu Leu Ile Leu His 
         595                600                605
Gln Ala Val Ala Val Ile Leu Ser Leu Glu Gln Gln Val Arg Glu Arg 
     610                615                620
Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys Arg Arg Glu Glu Glu Lys 
 625                630                635                640
Val Ser Ser Glu Pro Pro Pro Leu Ser Leu Ala Gly Pro His Pro Gly 
                 645                650                655
Met Gly Asp Ala Ser Asn His Met Gly Gln Met 
             660                665



<210> 8037
<211> 7851
<212> DNA
<213> Rattus norvegicus
<308> U09357
<400> 8037

cctagaccc  ggccagtca  cggcgtccc  tgtctcggt  ttcccactc  ctgcaccct  60
agctgtacc  ctgcggctg  cgaggggcc  cggacccgg  tggagatgc  aatcctgca  120
agcttcctc  cgtgcgttc  gctactgtg  gtgtgtcgc  tggactggg  ttatggata  180
tacagacaa  agagaaaac  tgttgaaga  attggctgg  cctatacag  agcactaaa  240
caaaaaaat  ggggaaaga  atatccaat  tgtaatagc  caaagcagt  tcctattaa  300
attgatgaa  atcttacac  agtaaatgt  aatcttaag  aactgaaat  tcagggttg  360
gaaaaacca  ccttggaaa  cacgtttat  cacaacact  ggaaaacag  ggaaataaa  420
ctcaccaat  actactatc  cagtggagg  ctttcagaa  aggtcttca  ggcaagcaa  480
atgactttt  actggggga  atgcaatgt  tcatcggaa  gatcggaac  cagcttaga  540
gggcagaag  ttccactcg  gatgcaaat  tactgcttc  atgcggacc  attttcaag  600
tttgaggaa  cagttaaag  aaaaggaag  ttaagggct  tatccattt  atttgagat  660
ggagttgaa  aaaatttgg  ttacaaagc  attattgat  ggactgaaa  tgttagtcg  720
tttggaaag  aggctgcct  agatccgtt  atcttgcag  acctcctgc  aaactccac  780
gacaagtac  acatttaca  cggatcact  acatcccct  cctgcacag  caccgtcga  840
tggattgtt  ttaaggata  agttagcat  tctgaaagc  agctggctg  attttgtga  900
gttctcaca  tgcaacagt  cgggtatgt  atgttgatg  attacttac  aaacaattt  960
cgagaacaa  agtacaagt  ttccaggca  gtgttttct  cgtacactg  gaaggaaga  1020
attcatgaa  cagtgtgca  ttcagaacc  gaaaatgtg  aagctgacc  tgagaatta  1080
accagcctt  tgatcacat  ggaaaggcc  cgggttgtt  atgacacaa  gattgagaa  1140
tttgcggtt  tgtaccagc  actggaggg  aacgaccaa  ccaagcatg  gtttttaac  1200
gatggctat  aggacttgg  tgccattct  aataactta  tacctaaca  gagttatgt  1260
ctccaaata  tggccatat  ctctaatgg  ctttatgga  agtacagtg  ccaattgat  1320
gtcgacatg  ctactgagg  tgctgaact  gacctcttt  ctgaattaa  tggaactga  1380
gaaataatc  aggaggaaa  ctatggaaa  ggcaatgaa  aagacactg  cttgaatcc  1440
ggtagagac  gtgccacaa  ccaaataag  aaaaaggaa  cccaggttt  taccacaac  1500
cactataat  acatgggga  taaatataa  gaagccaag  ctaaccgat  tccaacgag  1560
ggatctgaa  tctctggaa  gagtgatgt  ctcaacaca  ccctgaatc  tacttccca  1620
caggttgct  aattcaatc  agaaagaga  atgtccttg  cttctcaga  tggaactaa  1680
ctgccacca  acagtgtgg  aggcacctc  gcctcctta  acagtggct  taaaactct  1740
cttgtcttc  cacagatga  cttgtctgg  actgcagaa  ccttaaata  ggtttccat  1800
acagagtac  aagaggtgt  tgctgacct  agtgaggaa  aaaacttac  gactgattt  1860
aagctcgat  gtggagcag  tgattcgtc  ggctctagc  ctgcatcct  cactgtccc  1920
ttttccaca  ataatctat  ccatggata  acgtcttct  cagacacgc  cgaggcggt  1980
acgtatgat  tccttaggc  agaatctac  agaaatgct  tagaggatt  ggctccatc  2040
ggttcagaa  aatcactaa  ggatccctc  cttgaaggg  gtgtgtggt  ccctggatc  2100
acagaccta  caacacagt  tgagactgg  tctgggaga  agggctttc  ccaagttaa  2160
tccacggac  tccaagttg  tgaatcgag  gagacaact  agacatttt  tccagatgc  2220
accgcgtcc  ggggtcctt  ggtcacaga  atggaaatg  cacattatt  tacctttgc  2280
taccccccg  ctgaagtaa  atcacatgc  ttcactccg  cctccagac  acttgattt  2340
gctcccact  gcaacatcc  ccattcgca  acaactcaa  cagtataca  tggtgagac  2400
cctcttcaa  cttcctaca  tagtgaagt  tttcctcta  tcacccctt  gttgcttga  2460
aatcagacc  tcaacacta  ccctgctgc  tcaagtagt  attcggcct  gcatgctac  2520
cctgtattc  ccagtgttg  tgtgtcatt  gactccatc  tgtcttcct  tgatgatgc  2580
cctctgctc  cattttcct  tgcttcctt  agtagtgac  tgtttcacc  tctgcatac  2640
gtttctcaa  cccttccgc  agttacttc  gctgctgag  gggatgagc  gtctttgca  2700
gcttctctg  tggtggctg  gggtgattt  ctgttagag  ccagccttg  tcagtattc  2760
gatgtgatg  cacatcagg  cactattca  gctgcttcg  acacattgg  atttggtag  2820
gagtctgct  tcctttata  aacgtctat  gtttctcaa  tcgaatcac  cagcagtga  2880
gtcgttatg  atgcatatt  gtcagggcc  gaaacttct  atgccattg  gggctccca  2940
cacgtgctc  ctgtttctt  cagttctgc  atacctgtg  atgattctg  cggtgtagc  3000
gatcagggg  ccttactta  caatcctag  catatatca  tgcctgagt  ctcatttat  3060
actccaact  catcattac  gcagcttcc  cctgccctc  ctggtgatg  ggagtggtc  3120
ggagcctcc  ctgatagtg  attgctttt  cctgacaca  atgggctga  aactcttaa  3180
atgtcttca  ctgtttctg  agctgattt  acatacacg  catctgtgt  tggcgatga  3240
attaagccg  tttctaaag  tgaaatgat  tatggaaat  agaccgaac  gaaaatgtc  3300
tctttcagt  acatggcat  cccttctaa  agcacagtc  tgccaaaga  gtctgatat  3360
gtaaataag  ggagtgaat  tttaaaaga  acctctgtt  ccgtatcta  cataaacag  3420
gtgtttaca  agtctcttg  ttatcccat  actaaggtt  ttgatcagg  gattagtcg  3480
gttccagag  ttatcttcc  agttaaacc  acacacaca  catctcaag  atctggtga  3540
acttggctt  aacccgggc  tagcacaaa  tcagagcct  cgctctctg  cactgcttc  3600
agtgaagta  cacaccctt  aacacagcc  ttgctctat  aggccgcat  tccttttaa  3660
acggaagca  tgctgcaac  ttcctttcc  gcttctgat  ttgacacct  gcttaaaac  3720
gcccttccc  ctgggcctc  tgatccagt  ctgactgaa  cccccatgg  tgagcaaag  3780
agctcttcc  tatctcttc  cctggcatc  gagtctgct  caagcaaaa  cacgctgca  3840
tttacatct  taccagttc  caatatgtc  ccttctgat  tgcacccca  ttcacttca  3900
cgcttaaca  ttcctcact  gagggagga  tattttgaa  aaggtttgc  taagagcaa  3960
agtccccag  aagtcctgc  gtccttgca  agccatgac  agtttttcc  aactgcaca  4020
ctggacatt  gccaggcct  ccctccaaa  ggaaggcat  catttgcta  tcctatttt  4080
tcaatcaat  aaccacaaa  tacacttat  aacaggctt  tgtattctg  ggacatttt  4140
atgcaccct  aaatttcta  tactgataa  gcacttact  gtctaccaa  gaccgtttc  4200
gatgtactt  tagctactg  ccattctgt  ccattagga  gtgggccca  ttccatgac  4260
actgtttct  ccaacagag  tgattctgt  accacaacc  agttgcttc  tccttctaa  4320
gctacttct  agccgactc  tagtgccag  tctgatgcc  atttagtag  aggtggtga  4380
gatggtgat  actatgatg  tgatgatta  gatgacata  atagtgatc  ctttcccgt  4440
aataagtgt  tgtcatgtt  accctatag  gaatcacag  aaaaggtaa  gaatgactc  4500
gacacccaa  aaagcagtc  tgtggatca  agtgaccca  tttcacatt  gctctctga  4560
aataccgaa  aagaaaatg  aggcacggg  gtaactagg  tggataaaa  tcctgataa  4620
tcaccacca  caagtatgc  accccagaa  cacaatgat  gaagagagg  ccgtgacat  4680
cagatgggt  gtgctgtcc  tcctcacac  ccaggatct  aagcatggg  agttttgac  4740
agtgatgaa  agagtgggt  agggcaagg  acctcagat  gccttaatg  taatgagac  4800
tccacagat  tcagtttcc  agatgttaa  gaaaaggat  ctgatggtg  cctggaagc  4860
gatgacaca  gcatagctc  gggatctcc  cggtcctcc  caccatctg  tactagtgg  4920
cattcagga  tatccaaca  ttcagaggc  gaggccagt  atagtagcc  tgagtctcg  4980
attggtcta  ctgaggggt  ggagtctga  aagaaggcg  ttatacccc  tgtgatcgt  5040
tctgccctg  cttttatct  tctagtggt  cttgttggt  ttctcatct  ctggagaaa  5100
tgcttccag  cggctcact  ttatttaga  gacaataca  cccctcgag  aatatctac  5160
ccaccaaca  ccatctttc  aatttcaga  gatattgga  caattccaa  aaagcattt  5220
ccaaagcac  tagcagact  acatgcaag  aatgggttc  ctgaagaat  tgagacact  5280
aaagagttt  accaggaag  gcagagctg  actgttgac  taggtatta  agcagacag  5340
tccaatcac  cagacaaca  gcacaagaa  agatatgtc  acatcgtag  ctatgatca  5400
agcagggtt  agctcacac  acttgctga  aaagatgga  aactgactg  ttacatcaa  5460
gccaattat  ttgatggtt  caacaggcc  aaggcttac  ttgctgccc  gggtccact  5520
aagtccaca  cagaagatt  ctggagaat  atatgggag  ataatgtgg  agtcatcgt  5580
atgataaca  acctcgtgg  gaaaggaag  agaaaatgt  accagtact  gcctactga  5640
ggcagtgaa  aatacggga  cttcctggt  aaccagaag  atgttcagg  gcttgctta  5700
tatactgtg  ggaatttca  cctaagaaa  acaaagata  aaaagggct  tcagaaagg  5760
agatccagt  gacgcctag  cactcagta  cattacacc  agtggcctg  tatgggtgt  5820
cccgagtac  ccctacccg  gctggcctt  gtgaggaag  ctgctcagg  caagcgaca  5880
gcagtcggg  cagttgttg  ccactgcag  gctggcgtg  ggagaacgg  cacatacat  5940
gtactagac  gtatgctac  gcagattca  cacgaagga  ccgtcaaca  atttggttt  6000
ttaaaacac  ttcgttctc  aaggaatta  ttggtgcaa  cagaggagc  atacgtctt  6060
attcacgac  cactggttg  ggccatact  agcaaagag  cagaggtgc  tgacagcca  6120
atccattcc  atgttaata  actcctcat  cccggacca  caggcaaga  aaaactaga  6180
aaacaattc  agcttctga  tcagtcaaa  attcttcag  gtgactact  cacggccct  6240
aagcagtgt  acagggaga  gaacagaac  tcctccatc  tccccgtgg  aagatcgag  6300
gtgggcatt  catccctga  tggggaagg  acagactac  tcaatgcat  ctatattat  6360
ggttattac  agagcaatg  attcatcat  acccagcac  cccttctac  caccatcaa  6420
gacttctgg  gaatgatat  ggatcataa  gcccagctg  tggttatga  tccagatgg  6480
caaaacatg  cagaggatg  atttgttta  tggccaaat  aagatgagc  cataaattg  6540
gagagcttc  aagtcacgc  tatgtctga  gaacacaaa  gtctttcga  tgaggaaaa  6600
ctgatagtt  aagacttca  cttggaagc  acacaggat  attatgtgc  ggaagtaag  6660
cattttcag  gcccgaaat  gccaaatcc  gatagtccc  ttagtaaaa  atttgaact  6720
ataagtatt  tcaaagaag  agctgctaa  agagatggg  ccatgattg  tcacgatga  6780
catggagga  taacagcag  gacattttg  gctctcaca  cccttatgc  ccaactaga  6840
aaagaaaac  ccatggatg  ttaccaagt  gccaagatg  tcaatttga  gaggccggg  6900
gtcttcact  acattgagc  gtaccagtt  ctctacaaa  tggtcctca  cctggtcag  6960
acaaggcag  aagagaatc  atccacctc  ctggatagt  atggtgcag  tttgcctga  7020
ggaaatata  ctgaaagcc  ggagtcttt  gtctgacgc  gaaagggtg  aggaccacc  7080
tcatccaag  agtgtctct  tctaaactt  gaaaaatga  tccagttct  ttatctgtt  7140
acttcccat  acctgacgg  aactcattc  gctgccaaa  tgacaccat  aacaacgtg  7200
gcctttttg  aagacttct  gtaatccac  tattatgtt  gaactaaaa  gattgaatt  7260
tacaatgtt  ctaagaatt  aattgtggc  tttttttcc  tattgattt  aacaacaac  7320
acaaaaaaa  tttgtagat  ataggaaac  ccaaccttg  gagatattt  ttcttaagt  7380
tcaaatttt  agctgtatt  gtagcaatc  tcaggtttg  tagaaatat  acttttaat  7440
tagtagatt  taagtaaac  actttatcc  cgatgatat  caacatttt  caactgcag  7500
attcacctg  agtaggagt  acagtaact  atgtaaata  tgccctggt  tctccatgg  7560
ccaaattta  atttataat  gtagatttt  atattttac  actgtgtga  ttttctagt  7620
gtgtacttg  gtttaatta  cttactctc  ggtcttaac  tactctaaa  gtcttctaa  7680
actgtactg  gttatccaa  aaactaacc  tctttctgc  tgtcatttt  acttttgtg  7740
aaataggaa  ccacttgtt  taaaagatg  ttttatgag  ataacacct  accaaacat  7800
ccttaaatg  tttttatct  agaagttgc  aaaataaat  taaatattg  c  7851



<210> 8038
<211> 2316
<212> PRT
<213> Rattus norvegicus
<308> Q62656
<400> 8038

Met Arg Ile Leu Gln Ser Phe Leu Ala Cys Val Gln Leu Leu Cys Val 
  1               5                  10                  15
Cys Arg Leu Asp Trp Ala Tyr Gly Tyr Tyr Arg Gln Gln Arg Lys Leu 
             20                  25                  30
Val Glu Glu Ile Gly Trp Ser Tyr Thr Gly Ala Leu Asn Gln Lys Asn 
         35                  40                  45
Trp Gly Lys Lys Tyr Pro Ile Cys Asn Ser Pro Lys Gln Ser Pro Ile 
     50                  55                  60
Asn Ile Asp Glu Asp Leu Thr Gln Val Asn Val Asn Leu Lys Lys Leu 
 65                  70                  75                  80
Lys Phe Gln Gly Trp Glu Lys Pro Ser Leu Glu Asn Thr Phe Ile His 
                 85                  90                  95
Asn Thr Gly Lys Thr Val Glu Ile Asn Leu Thr Asn Asp Tyr Tyr Leu 
             100                105                110
Ser Gly Gly Leu Ser Glu Lys Val Phe Lys Ala Ser Lys Met Thr Phe 
         115                120                125
His Trp Gly Lys Cys Asn Val Ser Ser Glu Gly Ser Glu His Ser Leu 
     130                135                140
Glu Gly Gln Lys Phe Pro Leu Glu Met Gln Ile Tyr Cys Phe Asp Ala 
 145                150                155                160
Asp Arg Phe Ser Ser Phe Glu Glu Thr Val Lys Gly Lys Gly Arg Leu 
                 165                170                175
Arg Ala Leu Ser Ile Leu Phe Glu Ile Gly Val Glu Glu Asn Leu Asp 
             180                185                190
Tyr Lys Ala Ile Ile Asp Gly Thr Glu Ser Val Ser Arg Phe Gly Lys 
         195                200                205
Gln Ala Ala Leu Asp Pro Phe Ile Leu Gln Asn Leu Leu Pro Asn Ser 
     210                215                220
Thr Asp Lys Tyr Tyr Ile Tyr Asn Gly Ser Leu Thr Ser Pro Pro Cys 
 225                230                235                240
Thr Asp Thr Val Glu Trp Ile Val Phe Lys Asp Thr Val Ser Ile Ser 
                 245                250                255
Glu Ser Gln Leu Ala Val Phe Cys Glu Val Leu Thr Met Gln Gln Ser 
             260                265                270
Gly Tyr Val Met Leu Met Asp Tyr Leu Gln Asn Asn Phe Arg Glu Gln 
         275                280                285
Gln Tyr Lys Phe Ser Arg Gln Val Phe Ser Ser Tyr Thr Gly Lys Glu 
     290                295                300
Glu Ile His Glu Ala Val Cys Ser Ser Glu Pro Glu Asn Val Gln Ala 
 305                310                315                320
Asp Pro Glu Asn Tyr Thr Ser Leu Leu Ile Thr Trp Glu Arg Pro Arg 
                 325                330                335
Val Val Tyr Asp Thr Met Ile Glu Lys Phe Ala Val Leu Tyr Gln Pro 
             340                345                350
Leu Glu Gly Asn Asp Gln Thr Lys His Glu Phe Leu Thr Asp Gly Tyr 
         355                360                365
Gln Asp Leu Gly Ala Ile Leu Asn Asn Leu Ile Pro Asn Met Ser Tyr 
     370                375                380
Val Leu Gln Ile Val Ala Ile Cys Ser Asn Gly Leu Tyr Gly Lys Tyr 
 385                390                395                400
Ser Asp Gln Leu Ile Val Asp Met Pro Thr Glu Asp Ala Glu Leu Asp 
                 405                410                415
Leu Phe Pro Glu Leu Ile Gly Thr Glu Glu Ile Ile Lys Glu Glu Asn 
             420                425                430
Tyr Gly Lys Gly Asn Glu Glu Asp Thr Gly Leu Asn Pro Gly Arg Asp 
         435                440                445
Ser Ala Thr Asn Gln Ile Arg Lys Lys Glu Pro Gln Val Ser Thr Thr 
     450                455                460
Thr His Tyr Asn His Met Gly Thr Lys Tyr Asn Glu Ala Lys Thr Asn 
 465                470                475                480
Arg Ser Pro Thr Arg Gly Ser Glu Phe Ser Gly Lys Ser Asp Val Leu 
                 485                490                495
Asn Thr Ser Leu Asn Pro Thr Ser Gln Gln Val Ala Glu Phe Asn Pro 
             500                505                510
Glu Arg Glu Met Ser Leu Pro Ser Gln Ile Gly Thr Asn Leu Pro Pro 
         515                520                525
His Ser Val Glu Gly Thr Ser Ala Ser Leu Asn Ser Gly Ser Lys Thr 
     530                535                540
Leu Leu Val Phe Pro Gln Met Asn Leu Ser Gly Thr Ala Glu Ser Leu 
 545                550                555                560
Asn Met Val Ser Ile Thr Glu Tyr Lys Glu Val Ser Ala Asp Leu Ser 
                 565                570                575
Glu Glu Glu Asn Leu Leu Thr Asp Phe Lys Leu Asp Ser Gly Ala Asp 
             580                585                590
Asp Ser Ser Gly Ser Ser Pro Ala Ser Ser Thr Val Pro Phe Ser Thr 
         595                600                605
Asp Asn Leu Ser His Gly Tyr Thr Ser Ser Ser Asp Thr Pro Glu Ala 
     610                615                620
Val Thr Tyr Asp Val Leu Arg Pro Glu Ser Thr Arg Asn Ala Leu Glu 
 625                630                635                640
Asp Ser Ala Pro Ser Gly Ser Glu Glu Ser Leu Lys Asp Pro Ser Leu 
                 645                650                655
Glu Gly Ser Val Trp Phe Pro Gly Ser Thr Asp Leu Thr Thr Gln Ser 
             660                665                670
Glu Thr Gly Ser Gly Arg Glu Gly Phe Leu Gln Val Asn Ser Thr Asp 
         675                680                685
Phe Gln Val Asp Glu Ser Arg Glu Thr Thr Glu Thr Phe Ser Pro Asp 
     690                695                700
Ala Thr Ala Ser Arg Gly Pro Ser Val Thr Asp Met Glu Met Pro His 
 705                710                715                720
Tyr Ser Thr Phe Ala Tyr Pro Pro Thr Glu Val Thr Ser His Ala Phe 
                 725                730                735
Thr Pro Ser Ser Arg Pro Leu Asp Leu Ala Pro Thr Ser Asn Ile Leu 
             740                745                750
His Ser Gln Thr Thr Gln Pro Val Tyr Asn Gly Glu Thr Pro Leu Gln 
         755                760                765
Pro Ser Tyr Ser Ser Glu Val Phe Pro Leu Val Thr Pro Leu Leu Leu 
     770                775                780
Asp Asn Gln Thr Leu Asn Thr Thr Pro Ala Ala Ser Ser Ser Asp Ser 
 785                790                795                800
Ala Leu His Ala Thr Pro Val Phe Pro Ser Val Gly Val Ser Phe Asp 
                 805                810                815
Ser Ile Leu Ser Ser Tyr Asp Asp Ala Pro Leu Leu Pro Phe Ser Ser 
             820                825                830
Ala Ser Phe Ser Ser Asp Leu Phe His His Leu His Thr Val Ser Gln 
         835                840                845
Thr Leu Pro Gln Val Thr Ser Ala Ala Glu Arg Asp Glu Leu Ser Leu 
     850                855                860
His Ala Ser Leu Leu Val Ala Gly Gly Asp Leu Leu Leu Glu Pro Ser 
 865                870                875                880
Leu Val Gln Tyr Ser Asp Val Met Ser His Gln Val Thr Ile His Ala 
                 885                890                895
Ala Ser Asp Thr Leu Glu Phe Gly Ser Glu Ser Ala Val Leu Tyr Lys 
             900                905                910
Thr Ser Met Val Ser Gln Ile Glu Ser Pro Ser Ser Asp Val Val Met 
         915                920                925
His Ala Tyr Ser Ser Gly Pro Glu Thr Ser Tyr Ala Ile Glu Gly Ser 
     930                935                940
His His Val Leu Thr Val Ser Ser Ser Ser Ala Ile Pro Val His Asp 
 945                950                955                960
Ser Val Gly Val Ala Asp Gln Gly Ser Leu Leu Ile Asn Pro Ser His 
                 965                970                975
Ile Ser Leu Pro Glu Ser Ser Phe Ile Thr Pro Thr Ala Ser Leu Leu 
             980                985                990
Gln Leu Pro Pro Ala Leu Ser Gly Asp Gly Glu Trp Ser Gly Ala Ser 
         995                1000                1005
Ser Asp Ser Glu Leu Leu Leu Pro Asp Thr Asp Gly Leu Arg Thr Leu 
     1010                1015                1020
Asn Met Ser Ser Pro Val Ser Val Ala Asp Phe Thr Tyr Thr Thr Ser 
 1025                1030                1035                1040
Val Ser Gly Asp Asp Ile Lys Pro Leu Ser Lys Gly Glu Met Met Tyr 
                 1045                1050                1055
Gly Asn Glu Thr Glu Leu Lys Met Ser Ser Phe Ser Asp Met Ala Tyr 
             1060                1065                1070
Pro Ser Lys Ser Thr Val Val Pro Lys Met Ser Asp Ile Val Asn Lys 
         1075                1080                1085
Trp Ser Glu Ser Leu Lys Glu Thr Ser Val Ser Val Ser Ser Ile Asn 
     1090                1095                1100
Ser Val Phe Thr Glu Ser Leu Val Tyr Pro Ile Thr Lys Val Phe Asp 
 1105                1110                1115                1120
Gln Glu Ile Ser Arg Val Pro Glu Ile Ile Phe Pro Val Lys Pro Thr 
                 1125                1130                1135
His Thr Ala Ser Gln Ala Ser Gly Asp Thr Trp Leu Lys Pro Gly Leu 
             1140                1145                1150
Ser Thr Asn Ser Glu Pro Ala Leu Ser Asp Thr Ala Ser Ser Glu Val 
         1155                1160                1165
Ser His Pro Ser Thr Gln Pro Leu Leu Tyr Glu Ala Ala Ser Pro Phe 
     1170                1175                1180
Asn Thr Glu Ala Leu Leu Gln Pro Ser Phe Pro Ala Ser Asp Val Asp 
 1185                1190                1195                1200
Thr Leu Leu Lys Thr Ala Leu Pro Ser Gly Pro Arg Asp Pro Val Leu 
                 1205                1210                1215
Thr Glu Thr Pro Met Val Glu Gln Ser Ser Ser Ser Val Ser Leu Pro 
             1220                1225                1230
Leu Ala Ser Glu Ser Ala Ser Ser Lys Ser Thr Leu His Phe Thr Ser 
         1235                1240                1245
Val Pro Val Leu Asn Met Ser Pro Ser Asp Val His Pro Thr Ser Leu 
     1250                1255                1260
Gln Arg Leu Thr Val Pro His Ser Arg Glu Glu Tyr Phe Glu Gln Gly 
 1265                1270                1275                1280
Leu Leu Lys Ser Lys Ser Pro Gln Gln Val Leu Pro Ser Leu His Ser 
                 1285                1290                1295
His Asp Glu Phe Phe Gln Thr Ala His Leu Asp Ile Ser Gln Ala Tyr 
             1300                1305                1310
Pro Pro Lys Gly Arg His Ala Phe Ala Thr Pro Ile Leu Ser Ile Asn 
         1315                1320                1325
Glu Pro Gln Asn Thr Leu Ile Asn Arg Leu Val Tyr Ser Glu Asp Ile 
     1330                1335                1340
Phe Met His Pro Glu Ile Ser Ile Thr Asp Lys Ala Leu Thr Gly Leu 
 1345                1350                1355                1360
Pro Thr Thr Val Ser Asp Val Leu Ile Ala Thr Asp His Ser Val Pro 
                 1365                1370                1375
Leu Gly Ser Gly Pro Ile Ser Met Thr Thr Val Ser Pro Asn Arg Asp 
             1380                1385                1390
Asp Ser Val Thr Thr Thr Lys Leu Leu Leu Pro Ser Lys Ala Thr Ser 
         1395                1400                1405
Lys Pro Thr His Ser Ala Arg Ser Asp Ala Asp Leu Val Gly Gly Gly 
     1410                1415                1420
Glu Asp Gly Asp Asp Tyr Asp Asp Asp Asp Tyr Asp Asp Ile Asp Ser 
 1425                1430                1435                1440
Asp Arg Phe Pro Val Asn Lys Cys Met Ser Cys Ser Pro Tyr Arg Glu 
                 1445                1450                1455
Ser Gln Glu Lys Val Met Asn Asp Ser Asp Thr Gln Glu Ser Ser Leu 
             1460                1465                1470
Val Asp Gln Ser Asp Pro Ile Ser His Leu Leu Ser Glu Asn Thr Glu 
         1475                1480                1485
Glu Glu Asn Gly Gly Thr Gly Val Thr Arg Val Asp Lys Ser Pro Asp 
     1490                1495                1500
Lys Ser Pro Pro Pro Ser Met Leu Pro Gln Lys His Asn Asp Gly Arg 
 1505                1510                1515                1520
Glu Asp Arg Asp Ile Gln Met Gly Ser Ala Val Leu Pro His Thr Pro 
                 1525                1530                1535
Gly Ser Lys Ala Trp Ala Val Leu Thr Ser Asp Glu Glu Ser Gly Ser 
             1540                1545                1550
Gly Gln Gly Thr Ser Asp Ser Leu Asn Asp Asn Glu Thr Ser Thr Asp 
         1555                1560                1565
Phe Ser Phe Pro Asp Val Asn Glu Lys Asp Ala Asp Gly Val Leu Glu 
     1570                1575                1580
Ala Asp Asp Thr Gly Ile Ala Pro Gly Ser Pro Arg Ser Ser Thr Pro 
 1585                1590                1595                1600
Ser Val Thr Ser Gly His Ser Gly Val Ser Asn Ser Ser Glu Ala Glu 
                 1605                1610                1615
Ala Ser Asn Ser Ser His Glu Ser Arg Ile Gly Leu Ala Glu Gly Leu 
             1620                1625                1630
Glu Ser Glu Lys Lys Ala Val Ile Pro Leu Val Ile Val Ser Ala Leu 
         1635                1640                1645
Thr Phe Ile Cys Leu Val Val Leu Val Gly Ile Leu Ile Tyr Trp Arg 
     1650                1655                1660
Lys Cys Phe Gln Thr Ala His Phe Tyr Leu Glu Asp Asn Thr Ser Pro 
 1665                1670                1675                1680
Arg Val Ile Ser Thr Pro Pro Thr Pro Ile Phe Pro Ile Ser Asp Asp 
                 1685                1690                1695
Ile Gly Ala Ile Pro Ile Lys His Phe Pro Lys His Val Ala Asp Leu 
             1700                1705                1710
His Ala Ser Asn Gly Phe Thr Glu Glu Phe Glu Thr Leu Lys Glu Phe 
         1715                1720                1725
Tyr Gln Glu Val Gln Ser Cys Thr Val Asp Leu Gly Ile Thr Ala Asp 
     1730                1735                1740
Ser Ser Asn His Pro Asp Asn Lys His Lys Asn Arg Tyr Val Asn Ile 
 1745                1750                1755                1760
Val Ala Tyr Asp His Ser Arg Val Lys Leu Thr Gln Leu Ala Glu Lys 
                 1765                1770                1775
Asp Gly Lys Leu Thr Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr 
             1780                1785                1790
Asn Arg Pro Lys Ala Tyr Ile Ala Ala Gln Gly Pro Leu Lys Ser Thr 
         1795                1800                1805
Ala Glu Asp Phe Trp Arg Met Ile Trp Glu His Asn Val Glu Val Ile 
     1810                1815                1820
Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys Cys Asp Gln 
 1825                1830                1835                1840
Tyr Trp Pro Thr Asp Gly Ser Glu Glu Tyr Gly Ser Phe Leu Val Asn 
                 1845                1850                1855
Gln Lys Asn Val Gln Val Leu Ala Tyr Tyr Thr Val Arg Asn Phe Thr 
             1860                1865                1870
Leu Arg Asn Thr Lys Ile Lys Lys Gly Ser Gln Lys Gly Arg Ser Ser 
         1875                1880                1885
Gly Arg Leu Val Thr Gln Tyr His Tyr Thr Gln Trp Pro Asp Met Gly 
     1890                1895                1900
Val Pro Glu Tyr Ser Leu Pro Val Leu Ala Phe Val Arg Lys Thr Ala 
 1905                1910                1915                1920
Gln Ala Lys Arg His Ala Val Gly Pro Val Val Val His Cys Ser Ala 
                 1925                1930                1935
Gly Val Gly Arg Thr Gly Thr Tyr Ile Val Leu Asp Ser Met Leu Gln 
             1940                1945                1950
Gln Ile Gln His Glu Gly Thr Val Asn Ile Phe Gly Phe Leu Lys His 
         1955                1960                1965
Ile Arg Ser Gln Arg Asn Tyr Leu Val Gln Thr Glu Glu Gln Tyr Val 
     1970                1975                1980
Phe Ile His Asp Thr Leu Val Glu Ala Ile Leu Ser Lys Glu Thr Glu 
 1985                1990                1995                2000
Val Pro Asp Ser His Ile His Ser Tyr Val Asn Thr Leu Leu Ile Pro 
                 2005                2010                2015
Gly Pro Ser Gly Lys Thr Lys Leu Glu Lys Gln Phe Gln Leu Leu Ser 
             2020                2025                2030
Gln Ser Asn Ile Leu Gln Ser Asp Tyr Ser Thr Ala Leu Lys Gln Cys 
         2035                2040                2045
Asn Arg Glu Lys Asn Arg Thr Ser Ser Ile Ile Pro Val Glu Arg Ser 
     2050                2055                2060
Arg Val Gly Ile Ser Ser Leu Ser Gly Glu Gly Thr Asp Tyr Ile Asn 
 2065                2070                2075                2080
Ala Ser Tyr Ile Met Gly Tyr Tyr Gln Ser Asn Glu Phe Ile Ile Thr 
                 2085                2090                2095
Gln His Pro Leu Leu His Thr Ile Lys Asp Phe Trp Arg Met Ile Trp 
             2100                2105                2110
Asp His Asn Ala Gln Leu Val Val Met Ile Pro Asp Gly Gln Asn Met 
         2115                2120                2125
Ala Glu Asp Glu Phe Val Tyr Trp Pro Asn Lys Asp Glu Pro Ile Asn 
     2130                2135                2140
Cys Glu Ser Phe Lys Val Thr Leu Met Ser Glu Glu His Lys Cys Leu 
 2145                2150                2155                2160
Ser Asn Glu Glu Lys Leu Ile Val Gln Asp Phe Ile Leu Glu Ala Thr 
                 2165                2170                2175
Gln Asp Asp Tyr Val Leu Glu Val Arg His Phe Gln Cys Pro Lys Trp 
             2180                2185                2190
Pro Asn Pro Asp Ser Pro Ile Ser Lys Thr Phe Glu Leu Ile Ser Ile 
         2195                2200                2205
Ile Lys Glu Glu Ala Ala Asn Arg Asp Gly Pro Met Ile Val His Asp 
     2210                2215                2220
Glu His Gly Gly Val Thr Ala Gly Thr Phe Cys Ala Leu Thr Thr Leu 
 2225                2230                2235                2240
Met His Gln Leu Glu Lys Glu Asn Ser Met Asp Val Tyr Gln Val Ala 
                 2245                2250                2255
Lys Met Ile Asn Leu Met Arg Pro Gly Val Phe Thr Asp Ile Glu Gln 
             2260                2265                2270
Tyr Gln Phe Leu Tyr Lys Val Val Leu Ser Leu Val Ser Thr Arg Gln 
         2275                2280                2285
Glu Glu Asn Pro Ser Thr Ser Leu Asp Ser Asn Gly Ala Ala Leu Pro 
     2290                2295                2300
Asp Gly Asn Ile Ala Glu Ser Leu Glu Ser Leu Val 
 2305                2310                2315



<210> 8039
<211> 7941
<212> DNA
<213> Homo sapiens
<308> M93426
<400> 8039

cacacatac  cacgcacga  ctcacttcg  tctatacac  ggaggatta  aacaaacaa  60
caaaaaaaa  atttccttc  ctccccctc  ctctccact  tgagaagca  aggagccgc  120
cggcgaggg  ccgcagacc  tctggaaat  cgaatccta  agcgtttcc  cgcttgcat  180
cagctcctc  gtgtttgcc  cctggattg  gctaatgga  actacagac  acagagaaa  240
cttgttgaa  agattggct  gtcctatac  ggagcactg  atcaaaaaa  ttggggaaa  300
aaatatcca  catgtaata  cccaaaaca  tctcctatc  atattgatg  agatcttac  360
caagtaaat  tgaatctta  gaaacttaa  tttcagggt  gggataaaa  atcattgga  420
aacacattc  ttcataaca  tgggaaaac  gtggaaatt  atctcacta  tgactaccg  480
gtcagcgga  gagtttcag  aatggtgtt  aaagcaagc  agataactt  tcactgggg  540
aaatgcaat  tgtcatctg  tggatcaga  catagttta  aaggacaaa  atttccact  600
gagatgcaa  tctactgct  tgatgcgga  cgattttca  gttttgagg  agcagtcaa  660
ggaaaaggg  agttaagag  tttatccat  ttgtttgag  ttgggacag  agaaaattt  720
gatttcaaa  cgattattg  tggagtcga  agtgttagt  gttttggga  gcaggctgc  780
ttagatcca  tcatactgt  gaaccttct  ccaaactca  ctgacaagt  ttacattta  840
aatggctca  tgacatctc  tccctgcac  gacacagtt  actggattg  ttttaaaga  900
acagttagc  tctctgaaa  ccagttggc  gttttttgt  aagttctta  aatgcaaca  960
tctggttat  tcatgctga  ggactactt  caaaacaat  ttcgagagc  acagtacaa  1020
ttctctaga  aggtgtttt  ctcatacac  ggaaaggaa  agattcatg  agcagtttg  1080
agttcagaa  cagaaaatg  tcaggctga  ccagagaat  ataccagcc  tcttgttac  1140
tgggaaaga  ctcgagtcg  ttatgatac  atgattgag  agtttgcag  tttgtacca  1200
cagttggat  gagaggacc  aaccaagca  gaatttttg  cagatggct  tcaagactt  1260
ggtgctatt  tcaataatt  gctacccaa  atgagttat  ttcttcaga  agtagccat  1320
tgcactaat  gcttatatg  aaaatacag  gaccaactg  ttgtcgaca  gcctactga  1380
aatcctgaa  ttgatcttt  ccctgaatt  attggaact  aagaaataa  caaggagga  1440
gaagaggga  aagacattg  agaaggcgc  attgtgaat  ctggtagag  cagtgctac  1500
aaccaaatc  ggaaaaagg  accccagat  tctaccaca  cacactaca  tcgcatagg  1560
acgaaatac  atgaagcca  gactaaccg  tccccaaca  gaggaagtg  attctctgg  1620
aagggtgat  ttcccaata  atctttaaa  tccacttcc  aaccagtca  taaattagc  1680
acagaaaaa  atatttcct  gacttctca  actgtgact  aactgccac  tcacactgt  1740
gaaggtact  cagcctctt  aaatgatgg  tctaaaact  ttcttagat  tccacatat  1800
aacttgtcg  ggactgcag  atccttaaa  acagtttct  taacagaat  tgaggagga  1860
agtttattg  ccagtttca  gcttgatac  ggagctgaa  attcttcag  ctccagtcc  1920
gcaacttct  ctatcccat  catctctga  aacatatcc  aagggtata  attttcctc  1980
gaaaaccca  agacaataa  atatgatgt  cttatacca  aatctgcta  aaatgcttc  2040
gaagattca  cttcatcag  ttcagaaga  tcactaaag  atccttcta  ggagggaaa  2100
gtgtggttt  ctagctcta  agacataac  gcacagccc  atgttggat  aggcagaga  2160
agctttctc  agactaatt  cactgagat  cgtgttgat  aatctgaga  gacaaccaa  2220
tccttttct  caggcccag  gatgtcaca  ggtccctca  ttacagatc  ggaaatgcc  2280
cattattct  cctttgcct  cttcccaac  gaggtaaca  ctcatgctt  taccccatc  2340
tccagacaa  aggatttgg  ctccacggt  aacgtggta  actcgcaga  aacccaacc  2400
gtatacaat  gtgagacac  tcttcaacc  tcctacagt  gtgaagtct  tcctctagt  2460
acccctttg  tgcttgaca  tcagatcct  aacactacc  ctgctgctt  aagtagtga  2520
tcggccttg  atgctacgc  tgtatttcc  agtgtcgat  tgtcatttg  atccatcct  2580
tcttcctat  atggtgcac  tttgcttcc  ttttcctct  cttccttca  tagtgaatt  2640
tttcgccat  tgcatacag  ttctcaaat  cttccacaa  ttacttcag  taccgagag  2700
gataaggtg  ccttgcatg  ttctctgcc  gtggctggg  gtgatttgc  attagagcc  2760
agccttgct  agtattctg  tgtgctgtc  actactcat  ctgcttcag  gacgctgga  2820
tttggtagt  aatctggtg  tctttataa  acgcttatg  tttctcaag  tgaaccacc  2880
agcagtgat  ccatgatgc  tgcacgttc  tcagggcct  aaccttctt  tgccttgtc  2940
gataatgag  gctcccaac  catcttcac  gtttcttac  gttctgcaa  acctgtgca  3000
gattctgtg  gtgtaactt  tcagggttc  ttatttagc  gccctagcc  tataccaat  3060
cctaagtct  cgttaataa  cccaactgc  tcattactg  agcctactc  tgccctctc  3120
ggtgatggg  aatggtctg  agcctcttc  gatagtgaa  ttcttttac  tgacacaga  3180
gggctgaca  cccttaaca  ttcttcacc  gtttctgta  ctgaattta  atatacaac  3240
tctgtgttt  gtgatgata  taaggcgct  tctaaaagt  aaataatat  tggaaatga  3300
actgaactg  aaattcctt  tttcaatga  atggtttac  cttctgaaa  cacagtcat  3360
cccaacatg  atgataatg  aaataagtt  aatgcgtct  tacaagaaa  ctctgtttc  3420
atttctagc  ccaagggca  gtttccagg  tcccttgct  ataccacca  taaggtttt  3480
gatcatgag  ttagtcaag  tccagaaaa  aacttttca  ttcaaccta  acatactgt  3540
tctcaagca  ctggtgaca  ttcgcttaa  cctgtgctt  gtgcaaact  agagccagc  3600
tcctctgac  ctgcttcta  tgaaatgtt  tctccttca  ctcagctct  attttatga  3660
acctcagct  cttttagta  tgaagtatt  ctacaacct  cctttcagg  ttctgatgt  3720
gacaccttg  ttaaaactg  tcttccagc  gtgcccagt  atccaatat  ggttgaaac  3780
cccaaagtt  ataaaatta  ttctacaat  ttgcatctc  ttgtatcaa  ttctgcttc  3840
agtgaaaac  tgctgcact  tacatctgt  ccagttttt  atgtgtcgc  tacttctca  3900
atgcactct  cttcacttc  aggtttgac  atttcctat  caagtgaga  atatgaacc  3960
gttttgtta  aaagtgaaa  ttcccacca  gtggtacct  ctttgtaca  taatgatga  4020
ttgttccaa  cggccaatt  ggagattaa  caggcccat  ccccaaaag  aaggcatgt  4080
tttgctaca  ctgttttat  aattgatga  ccattaaat  cactaataa  taagcttat  4140
cattccgat  aaattttaa  ctccaccaa  agttctgtt  ctggtaagg  atttgctgg  4200
attccaaca  ttgcttctg  tacatttgt  tctactgat  attctgttc  tataggaaa  4260
gggcatgtt  ccattacag  tgtttctcc  cacagagat  gttctgtaa  ctcaacaaa  4320
ttgctgttt  cttctaagg  aacttctga  ctgagtcat  gtgccaaat  tgatgccgg  4380
ttagtgggt  gtggtgaag  tggtgacac  gatgatgat  gtgatgatg  tgatgacag  4440
gatagtgat  gcttatcca  tcataagtg  atgtcatgc  catcctata  agaatcaca  4500
gaaaaggta  tgaatgatt  agacaccca  gaaaacagt  ttatggatc  gaataatcc  4560
atctcatac  cactatctg  gaattctga  gaagataat  gagtcacaa  tgtatcctc  4620
gacagtcaa  ctggtatgg  cagaagtcc  ggtaaatca  catcagcaa  tgggctatc  4680
caaaagcac  atgatggaa  agaggaaaa  gacattcag  ctggtagtg  tctgcttcc  4740
ctcagccct  aatctaaag  atgggcagt  ctgacaagt  atgaagaaa  tggatcagg  4800
caaggtacc  cagatagcc  taatgagaa  gagacttcc  cagatttca  ttttgcaga  4860
actaatgaa  aagatgctg  tgggatcct  gcagcaggt  actcagaaa  aactcctgg  4920
ttcccacag  ccccaacat  atctgttac  agcgagaac  cagaagtgt  ccacgtttc  4980
gaggcagag  ccagtaata  tagccatga  tctcgtatt  gtctagctg  ggggttgga  5040
tccgagaag  aggcagtta  accccttgt  atcgtgtca  ccctgactt  tatctgtct  5100
gtggttctt  tgggtattc  catctactg  aggaaatgc  tccagactg  acactttta  5160
ttagaggac  gtacatccc  tagagttat  tccacacct  caacaccta  ctttccaat  5220
tcagatgat  tcggagcaa  tccaataaa  cactttcca  agcatgttg  agatttaca  5280
gcaagtagt  ggtttactg  agaatttga  acactgaaa  agttttacc  ggaagtgca  5340
agctgtact  ttgacttag  tattacagc  gacagctcc  accacccag  caacaagca  5400
aagaatcga  acataaata  cgttgccta  gatcatagc  gggttaagc  agcacagct  5460
gctgaaaag  atggcaaac  gactgatta  atcaatgcc  attatgttg  tggctacaa  5520
agaccaaaa  cttatattg  tgcccaagg  ccactgaaa  ccacagctg  agatttctg  5580
agaatgata  gggaacata  tgtggaagt  attgtcatg  taacaaacc  cgtggagaa  5640
ggaaggaga  aatgtgatc  gtactggcc  gccgatggg  gtgaggagt  cgggaactt  5700
ctggtcact  agaagagtg  gcaagtgct  gcctattat  ctgtgagga  ttttactct  5760
agaaacaca  aaataaaaa  gggctccca  aaaggaaga  ccagtggac  tgtggtcac  5820
cagtatcac  acacgcagt  gcctgacat  ggagtacca  agtactccc  gccagtgct  5880
acctttgtg  gaaaggcag  ctatgccaa  cgccatgca  tggggcctg  tgtcgtcca  5940
tgcagtgct  gagttggaa  aacaggcac  tatattgtg  tagacagta  gttgcagca  6000
attcaacac  aaggaactg  caacatatt  ggcttctta  aacacatcc  ttcacaaag  6060
aattatttg  tacaaactg  ggagcaata  gtcttcatt  atgatacac  ggttgaggc  6120
atacttagt  aagaaactg  ggtgctgga  agtcatatt  atgcctatg  taatgcact  6180
ctcattcct  gaccagcag  caaaacaaa  ctagagaaa  aattccagc  cctgagcca  6240
tcaaatata  agcagagtg  ctattctgc  gccctaaag  aatgcaaca  ggaaaagaa  6300
cgaacttct  ctatcatcc  tgtggaaag  tcaagggtt  gcatttcat  cctgagtgg  6360
gaaggcaca  actacatca  tgcctccta  atcatgggc  attaccaga  caatgaatt  6420
atcattacc  agcaccctc  ccttcatac  atcaaggat  tctggagga  gatatggga  6480
cataatgcc  aactggtgg  tatgattcc  gatggccaa  acatggcag  agatgaatt  6540
gtttactgg  caaataaag  tgagcctat  aattgtgag  gctttaagg  cactcttat  6600
gctgaagaa  acaaatgtc  atctaatga  gaaaaactt  taattcagg  ctttatctt  6660
gaagctaca  aggatgatt  tgtacttga  gtgaggcac  ttcagtgtc  taaatggcc  6720
aatccagat  gccccatta  taaaacttt  gaacttata  gtgttataa  agaagaagc  6780
gccaatagg  atgggccta  gattgttca  gatgagcat  gaggagtga  ggcaggaac  6840
ttctgtgct  tgacaaccc  tatgcacca  ctagaaaaa  aaaattccg  ggatgttta  6900
caggtagcc  agatgatca  tctgatgag  ccaggagtc  ttgctgaca  tgagcagta  6960
cagtttctc  acaaagtga  cctcagcct  gtgagcaca  ggcaggaag  gaatccatc  7020
acctctctg  acagtaatg  tgcagcatt  cctgatgga  atatagctg  gagcttaga  7080
tctttagtt  aacacagaa  ggggtgggg  gactcacat  tgagcattg  tttcctctt  7140
ctaaaatta  gcaggaaaa  cagtctagt  ctgttatct  ttgatttcc  atcacctga  7200
agtaacttt  atgacatag  attctgccg  caaatttat  tcattaaca  tgtgtgcct  7260
tttgcaaga  ttgtaattt  cttattatg  ttgaactaa  atgattgaa  tttacagta  7320
ttctaagaa  ggaattgtg  tattttttt  tgtattgat  ttaacagaa  atttcaatt  7380
atagaggtt  ggaattcca  actacagaa  atgtttgtt  ttagtgtca  atttttagc  7440
gtatttgta  caattatca  gtttgctag  aatataact  ttaatacag  agcctgtaa  7500
taaaacact  ttccatatg  tattcaaca  tttacaact  cagtattca  ctaaagtag  7560
aataatctg  tacttattg  aaatactgc  ctagtgtct  catggacca  atttatatt  7620
ataattgta  atttttata  tttactact  agtcaagtt  tctagttct  tgtaattgt  7680
tagtttaat  acgtagttc  ttagctggt  ttactctac  agttttctg  cattgtatt  7740
tgttaccta  gtcattaac  ttgtttcag  atgtaattt  aacttttgt  gaaaataga  7800
ataccttca  tttgaaaga  gtttttatg  gaataacac  ttaccaaac  ttgttcaaa  7860
ggtttttat  caaggaatt  caaaaataa  tataaatat  gccattaaa  aaaaaaaaa  7920
aaaaaaaaa  aaaaaaaaa  a  7941



<210> 8040
<211> 2314
<212> PRT
<213> Homo sapiens
<308> P23471
<400> 8040

Met Arg Ile Leu Lys Arg Phe Leu Ala Cys Ile Gln Leu Leu Cys Val 
  1               5                  10                  15
Cys Arg Leu Asp Trp Ala Asn Gly Tyr Tyr Arg Gln Gln Arg Lys Leu 
             20                  25                  30
Val Glu Glu Ile Gly Trp Ser Tyr Thr Gly Ala Leu Asn Gln Lys Asn 
         35                  40                  45
Trp Gly Lys Lys Tyr Pro Thr Cys Asn Ser Pro Lys Gln Ser Pro Ile 
     50                  55                  60
Asn Ile Asp Glu Asp Leu Thr Gln Val Asn Val Asn Leu Lys Lys Leu 
 65                  70                  75                  80
Lys Phe Gln Gly Trp Asp Lys Thr Ser Leu Glu Asn Thr Phe Ile His 
                 85                  90                  95
Asn Thr Gly Lys Thr Val Glu Ile Asn Leu Thr Asn Asp Tyr Arg Val 
             100                105                110
Ser Gly Gly Val Ser Glu Met Val Phe Lys Ala Ser Lys Ile Thr Phe 
         115                120                125
His Trp Gly Lys Cys Asn Met Ser Ser Asp Gly Ser Glu His Ser Leu 
     130                135                140
Glu Gly Gln Lys Phe Pro Leu Glu Met Gln Ile Tyr Cys Phe Asp Ala 
 145                150                155                160
Asp Arg Phe Ser Ser Phe Glu Glu Ala Val Lys Gly Lys Gly Lys Leu 
                 165                170                175
Arg Ala Leu Ser Ile Leu Phe Glu Val Gly Thr Glu Glu Asn Leu Asp 
             180                185                190
Phe Lys Ala Ile Ile Asp Gly Val Glu Ser Val Ser Arg Phe Gly Lys 
         195                200                205
Gln Ala Ala Leu Asp Pro Phe Ile Leu Leu Asn Leu Leu Pro Asn Ser 
     210                215                220
Thr Asp Lys Tyr Tyr Ile Tyr Asn Gly Ser Leu Thr Ser Pro Pro Cys 
 225                230                235                240
Thr Asp Thr Val Asp Trp Ile Val Phe Lys Asp Thr Val Ser Ile Ser 
                 245                250                255
Glu Ser Gln Leu Ala Val Phe Cys Glu Val Leu Thr Met Gln Gln Ser 
             260                265                270
Gly Tyr Val Met Leu Met Asp Tyr Leu Gln Asn Asn Phe Arg Glu Gln 
         275                280                285
Gln Tyr Lys Phe Ser Arg Gln Val Phe Ser Ser Tyr Thr Gly Lys Glu 
     290                295                300
Glu Ile His Glu Ala Val Cys Ser Ser Glu Pro Glu Asn Val Gln Ala 
 305                310                315                320
Asp Pro Glu Asn Tyr Thr Ser Leu Leu Val Thr Trp Glu Arg Pro Arg 
                 325                330                335
Val Val Tyr Asp Thr Met Ile Glu Lys Phe Ala Val Leu Tyr Gln Gln 
             340                345                350
Leu Asp Gly Glu Asp Gln Thr Lys His Glu Phe Leu Thr Asp Gly Tyr 
         355                360                365
Gln Asp Leu Gly Ala Ile Leu Asn Asn Leu Leu Pro Asn Met Ser Tyr 
     370                375                380
Val Leu Gln Ile Val Ala Ile Cys Thr Asn Gly Leu Tyr Gly Lys Tyr 
 385                390                395                400
Ser Asp Gln Leu Ile Val Asp Met Pro Thr Asp Asn Pro Glu Leu Asp 
                 405                410                415
Leu Phe Pro Glu Leu Ile Gly Thr Glu Glu Ile Ile Lys Glu Glu Glu 
             420                425                430
Glu Gly Lys Asp Ile Glu Glu Gly Ala Ile Val Asn Pro Gly Arg Asp 
         435                440                445
Ser Ala Thr Asn Gln Ile Arg Lys Lys Glu Pro Gln Ile Ser Thr Thr 
     450                455                460
Thr His Tyr Asn Arg Ile Gly Thr Lys Tyr Asn Glu Ala Lys Thr Asn 
 465                470                475                480
Arg Ser Pro Thr Arg Gly Ser Glu Phe Ser Gly Lys Gly Asp Val Pro 
                 485                490                495
Asn Thr Ser Leu Asn Ser Thr Ser Gln Pro Val Thr Lys Leu Ala Thr 
             500                505                510
Glu Lys Asp Ile Ser Leu Thr Ser Gln Thr Val Thr Glu Leu Pro Pro 
         515                520                525
His Thr Val Glu Gly Thr Ser Ala Ser Leu Asn Asp Gly Ser Lys Thr 
     530                535                540
Val Leu Arg Ser Pro His Met Asn Leu Ser Gly Thr Ala Glu Ser Leu 
 545                550                555                560
Asn Thr Val Ser Ile Thr Glu Tyr Glu Glu Glu Ser Leu Leu Thr Ser 
                 565                570                575
Phe Lys Leu Asp Thr Gly Ala Glu Asp Ser Ser Gly Ser Ser Pro Ala 
             580                585                590
Thr Ser Ala Ile Pro Phe Ile Ser Glu Asn Ile Ser Gln Gly Tyr Ile 
         595                600                605
Phe Ser Ser Glu Asn Pro Glu Thr Ile Thr Tyr Asp Val Leu Ile Pro 
     610                615                620
Glu Ser Ala Arg Asn Ala Ser Glu Asp Ser Thr Ser Ser Gly Ser Glu 
 625                630                635                640
Glu Ser Leu Lys Asp Pro Ser Met Glu Gly Asn Val Trp Phe Pro Ser 
                 645                650                655
Ser Thr Asp Ile Thr Ala Gln Pro Asp Val Gly Ser Gly Arg Glu Ser 
             660                665                670
Phe Leu Gln Thr Asn Tyr Thr Glu Ile Arg Val Asp Glu Ser Glu Lys 
         675                680                685
Thr Thr Lys Ser Phe Ser Ala Gly Pro Val Met Ser Gln Gly Pro Ser 
     690                695                700
Val Thr Asp Leu Glu Met Pro His Tyr Ser Thr Phe Ala Tyr Phe Pro 
 705                710                715                720
Thr Glu Val Thr Pro His Ala Phe Thr Pro Ser Ser Arg Gln Gln Asp 
                 725                730                735
Leu Val Ser Thr Val Asn Val Val Tyr Ser Gln Thr Thr Gln Pro Val 
             740                745                750
Tyr Asn Gly Glu Thr Pro Leu Gln Pro Ser Tyr Ser Ser Glu Val Phe 
         755                760                765
Pro Leu Val Thr Pro Leu Leu Leu Asp Asn Gln Ile Leu Asn Thr Thr 
     770                775                780
Pro Ala Ala Ser Ser Ser Asp Ser Ala Leu His Ala Thr Pro Val Phe 
 785                790                795                800
Pro Ser Val Asp Val Ser Phe Glu Ser Ile Leu Ser Ser Tyr Asp Gly 
                 805                810                815
Ala Pro Leu Leu Pro Phe Ser Ser Ala Ser Phe Ser Ser Glu Leu Phe 
             820                825                830
Arg His Leu His Thr Val Ser Gln Ile Leu Pro Gln Val Thr Ser Ala 
         835                840                845
Thr Glu Ser Asp Lys Val Pro Leu His Ala Ser Leu Pro Val Ala Gly 
     850                855                860
Gly Asp Leu Leu Leu Glu Pro Ser Leu Ala Gln Tyr Ser Asp Val Leu 
 865                870                875                880
Ser Thr Thr His Ala Ala Ser Glu Thr Leu Glu Phe Gly Ser Glu Ser 
                 885                890                895
Gly Val Leu Tyr Lys Thr Leu Met Phe Ser Gln Val Glu Pro Pro Ser 
             900                905                910
Ser Asp Ala Met Met His Ala Arg Ser Ser Gly Pro Glu Pro Ser Tyr 
         915                920                925
Ala Leu Ser Asp Asn Glu Gly Ser Gln His Ile Phe Thr Val Ser Tyr 
     930                935                940
Ser Ser Ala Ile Pro Val His Asp Ser Val Gly Val Thr Tyr Gln Gly 
 945                950                955                960
Ser Leu Phe Ser Gly Pro Ser His Ile Pro Ile Pro Lys Ser Ser Leu 
                 965                970                975
Ile Thr Pro Thr Ala Ser Leu Leu Gln Pro Thr His Ala Leu Ser Gly 
             980                985                990
Asp Gly Glu Trp Ser Gly Ala Ser Ser Asp Ser Glu Phe Leu Leu Pro 
         995                1000                1005
Asp Thr Asp Gly Leu Thr Ala Leu Asn Ile Ser Ser Pro Val Ser Val 
     1010                1015                1020
Ala Glu Phe Thr Tyr Thr Thr Ser Val Phe Gly Asp Asp Asn Lys Ala 
 1025                1030                1035                1040
Leu Ser Lys Ser Glu Ile Ile Tyr Gly Asn Glu Thr Glu Leu Gln Ile 
                 1045                1050                1055
Pro Ser Phe Asn Glu Met Val Tyr Pro Ser Glu Ser Thr Val Met Pro 
             1060                1065                1070
Asn Met Tyr Asp Asn Val Asn Lys Leu Asn Ala Ser Leu Gln Glu Thr 
         1075                1080                1085
Ser Val Ser Ile Ser Ser Thr Lys Gly Met Phe Pro Gly Ser Leu Ala 
     1090                1095                1100
His Thr Thr Thr Lys Val Phe Asp His Glu Ile Ser Gln Val Pro Glu 
 1105                1110                1115                1120
Asn Asn Phe Ser Val Gln Pro Thr His Thr Val Ser Gln Ala Ser Gly 
                 1125                1130                1135
Asp Thr Ser Leu Lys Pro Val Leu Ser Ala Asn Ser Glu Pro Ala Ser 
             1140                1145                1150
Ser Asp Pro Ala Ser Ser Glu Met Leu Ser Pro Ser Thr Gln Leu Leu 
         1155                1160                1165
Phe Tyr Glu Thr Ser Ala Ser Phe Ser Thr Glu Val Leu Leu Gln Pro 
     1170                1175                1180
Ser Phe Gln Ala Ser Asp Val Asp Thr Leu Leu Lys Thr Val Leu Pro 
 1185                1190                1195                1200
Ala Val Pro Ser Asp Pro Ile Leu Val Glu Thr Pro Lys Val Asp Lys 
                 1205                1210                1215
Ile Ser Ser Thr Met Leu His Leu Ile Val Ser Asn Ser Ala Ser Ser 
             1220                1225                1230
Glu Asn Met Leu His Ser Thr Ser Val Pro Val Phe Asp Val Ser Pro 
         1235                1240                1245
Thr Ser His Met His Ser Ala Ser Leu Gln Gly Leu Thr Ile Ser Tyr 
     1250                1255                1260
Ala Ser Glu Lys Tyr Glu Pro Val Leu Leu Lys Ser Glu Ser Ser His 
 1265                1270                1275                1280
Gln Val Val Pro Ser Leu Tyr Ser Asn Asp Glu Leu Phe Gln Thr Ala 
                 1285                1290                1295
Asn Leu Glu Ile Asn Gln Ala His Pro Pro Lys Gly Arg His Val Phe 
             1300                1305                1310
Ala Thr Pro Val Leu Ser Ile Asp Glu Pro Leu Asn Thr Leu Ile Asn 
         1315                1320                1325
Lys Leu Ile His Ser Asp Glu Ile Leu Thr Ser Thr Lys Ser Ser Val 
     1330                1335                1340
Thr Gly Lys Val Phe Ala Gly Ile Pro Thr Val Ala Ser Asp Thr Phe 
 1345                1350                1355                1360
Val Ser Thr Asp His Ser Val Pro Ile Gly Asn Gly His Val Ala Ile 
                 1365                1370                1375
Thr Ala Val Ser Pro His Arg Asp Gly Ser Val Thr Ser Thr Lys Leu 
             1380                1385                1390
Leu Phe Pro Ser Lys Ala Thr Ser Glu Leu Ser His Ser Ala Lys Ser 
         1395                1400                1405
Asp Ala Gly Leu Val Gly Gly Gly Glu Asp Gly Asp Thr Asp Asp Asp 
     1410                1415                1420
Gly Asp Asp Asp Asp Asp Arg Asp Ser Asp Gly Leu Ser Ile His Lys 
 1425                1430                1435                1440
Cys Met Ser Cys Ser Ser Tyr Arg Glu Ser Gln Glu Lys Val Met Asn 
                 1445                1450                1455
Asp Ser Asp Thr His Glu Asn Ser Leu Met Asp Gln Asn Asn Pro Ile 
             1460                1465                1470
Ser Tyr Ser Leu Ser Glu Asn Ser Glu Glu Asp Asn Arg Val Thr Ser 
         1475                1480                1485
Val Ser Ser Asp Ser Gln Thr Gly Met Asp Arg Ser Pro Gly Lys Ser 
     1490                1495                1500
Pro Ser Ala Asn Gly Leu Ser Gln Lys His Asn Asp Gly Lys Glu Glu 
 1505                1510                1515                1520
Asn Asp Ile Gln Thr Gly Ser Ala Leu Leu Pro Leu Ser Pro Glu Ser 
                 1525                1530                1535
Lys Ala Trp Ala Val Leu Thr Ser Asp Glu Glu Ser Gly Ser Gly Gln 
             1540                1545                1550
Gly Thr Ser Asp Ser Leu Asn Glu Asn Glu Thr Ser Thr Asp Phe Ser 
         1555                1560                1565
Phe Ala Asp Thr Asn Glu Lys Asp Ala Asp Gly Ile Leu Ala Ala Gly 
     1570                1575                1580
Asp Ser Glu Ile Thr Pro Gly Phe Pro Gln Ser Pro Thr Ser Ser Val 
 1585                1590                1595                1600
Thr Ser Glu Asn Ser Glu Val Phe His Val Ser Glu Ala Glu Ala Ser 
                 1605                1610                1615
Asn Ser Ser His Glu Ser Arg Ile Gly Leu Ala Glu Gly Leu Glu Ser 
             1620                1625                1630
Glu Lys Lys Ala Val Ile Pro Leu Val Ile Val Ser Ala Leu Thr Phe 
         1635                1640                1645
Ile Cys Leu Val Val Leu Val Gly Ile Leu Ile Tyr Trp Arg Lys Cys 
     1650                1655                1660
Phe Gln Thr Ala His Phe Tyr Leu Glu Asp Ser Thr Ser Pro Arg Val 
 1665                1670                1675                1680
Ile Ser Thr Pro Pro Thr Pro Ile Phe Pro Ile Ser Asp Asp Val Gly 
                 1685                1690                1695
Ala Ile Pro Ile Lys His Phe Pro Lys His Val Ala Asp Leu His Ala 
             1700                1705                1710
Ser Ser Gly Phe Thr Glu Glu Phe Glu Thr Leu Lys Glu Phe Tyr Gln 
         1715                1720                1725
Glu Val Gln Ser Cys Thr Val Asp Leu Gly Ile Thr Ala Asp Ser Ser 
     1730                1735                1740
Asn His Pro Asp Asn Lys His Lys Asn Arg Tyr Ile Asn Ile Val Ala 
 1745                1750                1755                1760
Tyr Asp His Ser Arg Val Lys Leu Ala Gln Leu Ala Glu Lys Asp Gly 
                 1765                1770                1775
Lys Leu Thr Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr Asn Arg 
             1780                1785                1790
Pro Lys Ala Tyr Ile Ala Ala Gln Gly Pro Leu Lys Ser Thr Ala Glu 
         1795                1800                1805
Asp Phe Trp Arg Met Ile Trp Glu His Asn Val Glu Val Ile Val Met 
     1810                1815                1820
Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys Cys Asp Gln Tyr Trp 
 1825                1830                1835                1840
Pro Ala Asp Gly Ser Glu Glu Tyr Gly Asn Phe Leu Val Thr Gln Lys 
                 1845                1850                1855
Ser Val Gln Val Leu Ala Tyr Tyr Thr Val Arg Asn Phe Thr Leu Arg 
             1860                1865                1870
Asn Thr Lys Ile Lys Lys Gly Ser Gln Lys Gly Arg Pro Ser Gly Arg 
         1875                1880                1885
Val Val Thr Gln Tyr His Tyr Thr Gln Trp Pro Asp Met Gly Val Pro 
     1890                1895                1900
Glu Tyr Ser Leu Pro Val Leu Thr Phe Val Arg Lys Ala Ala Tyr Ala 
 1905                1910                1915                1920
Lys Arg His Ala Val Gly Pro Val Val Val His Cys Ser Ala Gly Val 
                 1925                1930                1935
Gly Arg Thr Gly Thr Tyr Ile Val Leu Asp Ser Met Leu Gln Gln Ile 
             1940                1945                1950
Gln His Glu Gly Thr Val Asn Ile Phe Gly Phe Leu Lys His Ile Arg 
         1955                1960                1965
Ser Gln Arg Asn Tyr Leu Val Gln Thr Glu Glu Gln Tyr Val Phe Ile 
     1970                1975                1980
His Asp Thr Leu Val Glu Ala Ile Leu Ser Lys Glu Thr Glu Val Leu 
 1985                1990                1995                2000
Asp Ser His Ile His Ala Tyr Val Asn Ala Leu Leu Ile Pro Gly Pro 
                 2005                2010                2015
Ala Gly Lys Thr Lys Leu Glu Lys Gln Phe Gln Leu Leu Ser Gln Ser 
             2020                2025                2030
Asn Ile Gln Gln Ser Asp Tyr Ser Ala Ala Leu Lys Gln Cys Asn Arg 
         2035                2040                2045
Glu Lys Asn Arg Thr Ser Ser Ile Ile Pro Val Glu Arg Ser Arg Val 
     2050                2055                2060
Gly Ile Ser Ser Leu Ser Gly Glu Gly Thr Asp Tyr Ile Asn Ala Ser 
 2065                2070                2075                2080
Tyr Ile Met Gly Tyr Tyr Gln Ser Asn Glu Phe Ile Ile Thr Gln His 
                 2085                2090                2095
Pro Leu Leu His Thr Ile Lys Asp Phe Trp Arg Met Ile Trp Asp His 
             2100                2105                2110
Asn Ala Gln Leu Val Val Met Ile Pro Asp Gly Gln Asn Met Ala Glu 
         2115                2120                2125
Asp Glu Phe Val Tyr Trp Pro Asn Lys Asp Glu Pro Ile Asn Cys Glu 
     2130                2135                2140
Ser Phe Lys Val Thr Leu Met Ala Glu Glu His Lys Cys Leu Ser Asn 
 2145                2150                2155                2160
Glu Glu Lys Leu Ile Ile Gln Asp Phe Ile Leu Glu Ala Thr Gln Asp 
                 2165                2170                2175
Asp Tyr Val Leu Glu Val Arg His Phe Gln Cys Pro Lys Trp Pro Asn 
             2180                2185                2190
Pro Asp Ser Pro Ile Ser Lys Thr Phe Glu Leu Ile Ser Val Ile Lys 
         2195                2200                2205
Glu Glu Ala Ala Asn Arg Asp Gly Pro Met Ile Val His Asp Glu His 
     2210                2215                2220
Gly Gly Val Thr Ala Gly Thr Phe Cys Ala Leu Thr Thr Leu Met His 
 2225                2230                2235                2240
Gln Leu Glu Lys Glu Asn Ser Val Asp Val Tyr Gln Val Ala Lys Met 
                 2245                2250                2255
Ile Asn Leu Met Arg Pro Gly Val Phe Ala Asp Ile Glu Gln Tyr Gln 
             2260                2265                2270
Phe Leu Tyr Lys Val Ile Leu Ser Leu Val Ser Thr Arg Gln Glu Glu 
         2275                2280                2285
Asn Pro Ser Thr Ser Leu Asp Ser Asn Gly Ala Ala Leu Pro Asp Gly 
     2290                2295                2300
Asn Ile Ala Glu Ser Leu Glu Ser Leu Val 
 2305                2310



<210> 8041
<211> 4964
<212> DNA
<213> Rattus norvegicus
<308> U09540
<400> 8041

gttgcagac  cctctgcga  gccagcttg  aagccgccg  cgggctggg  tttagctcc  60
ctttatcaa  tcccaaccc  tcacccatc  caaccgcaa  tccaactct  tgagaaagt  120
ctgactttg  ggagcccca  gtgcactgg  gctcagcaa  cttgagaca  ttcccccct  180
tcctccatc  taatctaag  ttaggttct  actgagcca  gagtgggtg  taaagcagc  240
ggcctcagg  gtctaggac  ccgggtcct  ggggactct  aggttgaag  cttgcagag  300
ctgggcaga  gctccagag  ttctcccag  ccccactgc  ctacaccgc  ggaaccgcg  360
ttcatcgca  catggccac  agccttagt  cagacagtc  acagcagct  agctcgctg  420
ctacccaac  gaccattct  ctgctactc  tttcggtcc  ggccatcgt  cacttaggc  480
agtggctgc  gcgccagtg  cgacggaaa  cgtggtcct  gcccccggg  ccctttcct  540
ggccattga  cggaaacgc  gcgtctgtt  gccgggcat  gcacttgta  ttcgctcgc  600
ttgcgaggc  ctatggcga  gtttttcag  tccgtctgg  cagctgtcc  gtggtggtg  660
tgaatggcg  gagtgccat  catcaggct  tggtgcagc  gggcggcgt  tttgcggac  720
ggcctccct  cgcctcttt  cgtgtggtg  ctggtggcc  cagcctggc  ttcggccac  780
actcagagc  ctggaagga  cggcgacgt  cagcctatg  cacgatgcg  gccttctcc  840
cccgccacc  gcgcagccg  ggtctcctc  agggccacg  gctgggaga  gctcgagag  900
tggtggcag  gttggtgcg  cgctgcgcc  gtggcgcct  cctcgatcc  acgcagccg  960
tcatagtgg  ggtggctaa  gtcatgagc  ctgtatgct  cggctgtcg  tacaaccac  1020
acgatgccg  gttcctgga  ctgctcagc  acaacgagg  gttcgggcg  accgtgggc  1080
cgggcagcc  ggtggacgt  atgccctgg  tgcagcttt  tcccaaccc  gtgcgcacc  1140
tcttccgcg  gttcgagca  atcaaccgc  acttcagca  cttcgtcct  gacaagttc  1200
tgaggcacc  agaaagcct  gtgcccggg  ctgctcctc  agacatgat  gacgccttc  1260
tcctctccg  cgaaaagaa  gcgactggg  accctggtg  cagtccctc  gggctggat  1320
tggaggatg  gcctgccac  attacagac  tctttggag  cagccagga  accctttcc  1380
ccgcgctgc  gtggctgct  atcctcttt  ccagatacc  ggatgtgca  gcccgcgtg  1440
aggccgagt  ggaccaggt  gtggggagg  accgcctgc  ctgcatgag  gaccaaccc  1500
acttaccat  cgtcatggc  tttctttat  aatccatgc  attcaccag  tttttgcct  1560
tcacccttc  acatgccac  actgccaac  cctttgttt  aggctacta  atccccaaa  1620
acacggtag  ttttgttaa  cagtggtct  tgaatcatg  cccagcaaa  tggtctaac  1680
cagaggact  tgatccggc  cgcttcctg  acaaggacg  cttcattaa  aaggcacta  1740
ccagcagcg  gatgatatt  tcagtgggc  aacgacggt  catcggcga  gagttgtct  1800
agacgcttc  gtttctctt  atctccatc  tcgctcatc  gtgcaattt  aaggctaac  1860
aaaacgagc  ctcaaacat  agtttcagt  acggcctga  cattaagcc  aagtcgttt  1920
aaatccatg  gtctctcag  gagtccatg  agctccttg  tagtgctgt  gagaagctg  1980
aagctgagg  agcttgcca  tgagagagg  agaggccgg  ggtaactga  atgttcaaa  2040
aaaaccatc  cattaactg  agaggaaaa  acagatttt  ttttctcca  cttcatttt  2100
gcctcagtt  tcaagaatg  gcggaaacc  agtggcctg  aggtgaggc  ggcttacca  2160
ttcatggct  ctcaccggc  agcagctgg  gatcctgaa  tattttgaa  ttgaagagt  2220
atagggtcc  aggaatttg  atactgttc  cccctcacc  ccattaaac  catgcacac  2280
aatcagcat  tgtgtacag  tatccaaca  aatatttca  taactctgc  tttttgggt  2340
gatttgaaa  ggaacttct  ttgcagaaa  tggccccat  ggaaaccac  gtaagcaga  2400
gcttaggat  tatatatat  tatatatat  ttcaagatt  aaagaagtg  tttaagtgt  2460
aaatataaa  agcagaaat  taccaagag  caaatgagc  ctcccttgt  gccctggac  2520
aggttttct  tctgcctgt  gatgtgcct  ccactctag  acggaccat  aagccgttt  2580
gctccccct  aatttatgg  tagtttaat  accacagta  gttttagag  ttagtgaat  2640
caaaggtaa  ttgtttgaa  ggcaaaagg  ttttgtaag  taaaactgt  tgtcattca  2700
ctgttcaaa  gaagcattc  agttatgag  gagaaaaag  tttgccagt  taacgtaag  2760
tttcaactt  gggatcgta  caaactgat  tgagtaata  gtcggataa  gtaaaaaat  2820
aaaaagcct  atgtcacca  atagcattc  ataaatttt  cataattat  cacaagcat  2880
atatgaata  taactattt  acaggaaag  acttgaata  tacatttct  atgtcatct  2940
gcaaaccaa  aagtataat  agttgggtg  aatttgccc  aatccagga  acgatcctg  3000
caaaatcga  ctgattaat  tcagggaag  aagtaacag  acgatcctt  cctttctta  3060
ttacagccc  tacacgaga  aaatctcaa  actaaacca  caaaaccat  ctctgatct  3120
gtaattgta  ttacaacgc  cttttcttt  ggaattgac  cctttcggt  gcgttaaga  3180
tccaaactc  tggctggct  tgattttaa  ttagtttaa  atccacctt  attattttg  3240
ttcggttga  gctggagaa  gtatggtta  tatctcaca  aaggtgaga  acctaacct  3300
tatctaagg  caaatgtca  aggcaacaa  caatcaaac  aacaaacaa  gccatgagt  3360
ctctgggtg  tcttattag  cgccctctg  caagaaact  agtaccact  gtagttggt  3420
gtttctttt  atgtgctat  actatggtt  ttgtaggtg  tttttaaat  gagtattaa  3480
gtctgcggt  ttgtgtttt  ttttaagtc  gaatctgaa  attgtcttg  gaggttgtt  3540
agcgactgc  tggggagac  gcagagacg  ctaaaattg  ctcttattt  ggatggcag  3600
ctgagcagc  gccttcctg  tagctgaga  aggagaaat  tatgtattt  gattgtgta  3660
acaatccga  acctgttaa  aagggttgg  tgagtggaa  agtagggac  gggcgcgtg  3720
ggggtttcc  atttctgtt  tcactgcaa  ttagacgga  caaaagaag  ccacggcac  3780
cagagagct  atggttggc  ctgtttcat  aggcttctt  gaattttcc  atcaaaatt  3840
caaaggaag  agtgtgtga  attcttgtg  gcagaggcc  gaagctgac  gacagagag  3900
gcatgagca  gagagaaat  tttaaatgg  ccccattca  tccaaatta  tctcttgac  3960
tgtaacatt  gaggcatga  gtttagaaa  aaaggagtt  caagggtca  gtcttacct  4020
caagtgtct  ttaagactg  ctggagacc  agccctcac  ctctctctc  cccatccac  4080
tctattttg  agttggaga  tgaattata  aaaatataa  gtaatcctt  tttaaattt  4140
tcacaacag  accccttga  tgtgaaaca  aggttgtgt  agtattttc  aggccttga  4200
ttcaactac  aaaattaac  ctgtaaaca  ttttaagtt  ttcagacat  ttaaaagca  4260
gcacctcag  aaggtcggg  cagtgattt  agcctccat  gcctcttta  tatgagaaa  4320
ttgtaagag  gaaaagtct  catgaacca  tctggactc  tcattaagc  aaccagacc  4380
agatgtttt  tgaacgtag  ggtcatgtt  gtctgatgc  ttcagcaaa  gggaaagaa  4440
ggggctact  tgtatatat  tagacccag  gaaaggaag  aggatacaa  tcaggaaag  4500
gtaacaatt  tcatattcg  aagctaata  attactggc  tagttggaa  gcctgcctt  4560
ttctgctac  gagggattt  ttttgctgg  caccatctt  atcagagta  ccacctcct  4620
tcagggcag  caaaaagta  gtttttatt  aatgtctcc  ttgcacagt  aagcttgga  4680
tatgtcaga  cgttgcttt  ttttttaaa  caaaaaata  gcctcaggt  tgttttatg  4740
attactcaa  agagttcat  ccccagaac  tagcctgta  ctgtgaaat  ttatcatgc  4800
ccttatgta  tcacaccag  gctgtgcta  attaaatag  gatcatcac  atggtatgc  4860
aattactgt  tttagcagt  acacagttg  gtgacagaa  gtgtatgtt  ccaggtgat  4920
ataacccag  aataattcc  tatttaacc  ctaaaaaaa  aaaa  4964



<210> 8042
<211> 543
<212> PRT
<213> Rattus norvegicus
<308> Q64678
<400> 8042

Met Ala Thr Ser Leu Ser Ala Asp Ser Pro Gln Gln Leu Ser Ser Leu 
  1               5                  10                  15
Ser Thr Gln Gln Thr Ile Leu Leu Leu Leu Val Ser Val Leu Ala Ile 
             20                  25                  30
Val His Leu Gly Gln Trp Leu Leu Arg Gln Trp Arg Arg Lys Pro Trp 
         35                  40                  45
Ser Ser Pro Pro Gly Pro Phe Pro Trp Pro Leu Ile Gly Asn Ala Ala 
     50                  55                  60
Ser Val Gly Arg Ala Ser His Leu Tyr Phe Ala Arg Leu Ala Arg Arg 
 65                  70                  75                  80
Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Val Val Val 
                 85                  90                  95
Leu Asn Gly Glu Ser Ala Ile His Gln Ala Leu Val Gln Gln Gly Gly 
             100                105                110
Val Phe Ala Asp Arg Pro Pro Phe Ala Ser Phe Arg Val Val Ser Gly 
         115                120                125
Gly Arg Ser Leu Ala Phe Gly His Tyr Ser Glu Arg Trp Lys Glu Arg 
     130                135                140
Arg Arg Ala Ala Tyr Gly Thr Met Arg Ala Phe Ser Thr Arg His Pro 
 145                150                155                160
Arg Ser Arg Gly Leu Leu Glu Gly His Ala Leu Gly Glu Ala Arg Glu 
                 165                170                175
Leu Val Ala Val Leu Val Arg Arg Cys Ala Gly Gly Ala Cys Leu Asp 
             180                185                190
Pro Thr Gln Pro Ile Ile Val Ala Val Ala Asn Val Met Ser Ala Val 
         195                200                205
Cys Phe Gly Cys Arg Tyr Asn His Asp Asp Ala Glu Phe Leu Glu Leu 
     210                215                220
Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
 225                230                235                240
Val Asp Val Met Pro Trp Leu Gln Leu Phe Pro Asn Pro Val Arg Thr 
                 245                250                255
Ile Phe Arg Glu Phe Glu Gln Ile Asn Arg Asn Phe Ser Asn Phe Val 
             260                265                270
Leu Asp Lys Phe Leu Arg His Arg Glu Ser Leu Val Pro Gly Ala Ala 
         275                280                285
Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
     290                295                300
Thr Gly Asp Pro Gly Asp Ser Pro Ser Gly Leu Asp Leu Glu Asp Val 
 305                310                315                320
Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                 325                330                335
Thr Ala Leu Leu Trp Leu Leu Ile Leu Phe Thr Arg Tyr Pro Asp Val 
             340                345                350
Gln Ala Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
         355                360                365
Leu Pro Cys Met Ser Asp Gln Pro Asn Leu Pro Tyr Val Met Ala Phe 
     370                375                380
Leu Tyr Glu Ser Met Arg Phe Thr Ser Phe Leu Pro Val Thr Leu Pro 
 385                390                395                400
His Ala Thr Thr Ala Asn Thr Phe Val Leu Gly Tyr Tyr Ile Pro Lys 
                 405                410                415
Asn Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Ala 
             420                425                430
Lys Trp Ser Asn Pro Glu Asp Phe Asp Pro Ala Arg Phe Leu Asp Lys 
         435                440                445
Asp Gly Phe Ile Asn Lys Ala Leu Ala Ser Ser Val Met Ile Phe Ser 
     450                455                460
Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Thr Leu Leu 
 465                470                475                480
Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asn Phe Lys Ala Asn 
                 485                490                495
Gln Asn Glu Pro Ser Asn Met Ser Phe Ser Tyr Gly Leu Ser Ile Lys 
             500                505                510
Pro Lys Ser Phe Lys Ile His Val Ser Leu Arg Glu Ser Met Lys Leu 
         515                520                525
Leu Asp Ser Ala Val Glu Lys Leu Gln Ala Glu Glu Ala Cys Gln 
     530                535                540



<210> 8043
<211> 5102
<212> DNA
<213> Homo sapiens
<308> U03688
<400> 8043

gcttctgcg  ctccagttg  gagagccgc  agggcatgg  aattgacgc  actcaccga  60
ccccagtct  aatctcaac  ctgtgagga  acctcgact  tgccaggtc  ccaagggca  120
cggggctcg  cgagcgagg  acccttctc  gtccccatc  caatccaag  gctcctggc  180
ctgacgacg  caagagact  gagtgggag  taaagcttc  agtgagggc  gcaggtgtc  240
aggccgggc  tgcgggttc  tgttgacgt  ttgccctag  caaaggtcc  agttccttc  300
cggagccgg  tgtcccgcg  cactggaaa  cgcacctcc  cgcagcatg  gcaccagcc  360
cagcccgaa  gacccttgg  cgctaaacc  gctgtccat  cagcagacc  cgctcctgc  420
actcctgtc  gtgctggcc  ctgtgcatg  gggccagcg  ctgctgagg  aacggaggc  480
gcagctccg  tccgcgccc  cgggcccgt  tgcgtggcc  ctgatcgga  acgcggcgg  540
ggtgggcca  gcggctcac  tctcgttcg  tcgcctggc  cggcgctac  gcgacgttt  600
ccagatccg  ctgggcagc  gccccatag  ggtgctgaa  ggcgagcgc  ccatccacc  660
ggccctggt  cagcagggc  cggccttcg  cgaccggcc  gccttcgcc  ccttccgtg  720
ggtgtccgg  ggccgcagc  tggctttcg  ccactactc  gagcactgg  aggtgcagc  780
gcgcgcagc  cacagcatg  tgcgcaact  cttcacgcg  cagccgcgc  gccgccaag  840
cctcgaggg  cacgtgctg  gcgaggcgc  cgagctggt  gcgctgctg  tgcgcggca  900
cgcggacgg  gccttcctc  acccgaggc  gctgaccgt  gtggccgtg  ccaacgtca  960
gagtgccgt  tgtttcggc  gccgctaca  ccacgacga  cccgagttc  gtgagctgc  1020
cagccacaa  gaagagttc  ggcgcacgg  gggcgcggg  agcctggtg  acgtgatgc  1080
ctggctgca  tacttcccc  acccggtgc  caccgtttt  cgcgaattc  agcagctca  1140
ccgcaactt  agcaacttc  tcctggaca  gttcttgag  cactgcgaa  gccttcggc  1200
cggggccgc  ccccgcgac  tgatggacg  ctttatcct  tctgcggaa  agaaggcgg  1260
cggggactc  cacggtggt  gcgcgcggc  ggatttgga  aacgtaccg  ccactatca  1320
tgacatctt  ggcgccagc  aggacaccc  gtccaccgc  ctgcagtgg  tgctcctcc  1380
cttcaccag  tatcctgat  tgcagactc  agtgcaggc  gaattggat  aggtcgtgg  1440
gagggaccg  ctgccttgt  tgggtgacc  gcccaacct  ccctatgtc  tggccttcc  1500
ttatgaagc  atgcgcttc  ccagctttg  gcctgtcac  attcctcat  ccaccactg  1560
caacacctc  gtcttgggc  accacattc  caaggacac  gtggttttt  tcaaccagt  1620
gtctgtgaa  catgaccca  tgaagtggc  taacccgga  aactttgat  cagctcgat  1680
cttggacaa  gatggcctc  tcaacaagg  cctgaccag  agagtgatg  ttttttcag  1740
gggcaaaag  cggtgcatt  gcgaagaac  ttctaagat  cagcttttt  tcttcatct  1800
catcctggc  caccagtgc  atttcaggg  caacccaaa  gagcctgcg  aaatgaatt  1860
cagttatgg  ctaaccatt  aacccaagt  atttaaagt  aatgtcact  tcagagagt  1920
catggagct  cttgatagt  ctgtccaaa  tttacaagc  aaggaaact  gccaataag  1980
agcaagagg  aagctgaaa  tttagaaat  ttcacatct  cggagatga  gagtaaaat  2040
cagtttttt  ccagttcct  ttttgtgct  cttctcaat  agcgtttaa  gtgagcata  2100
atcaactgt  catcaggtg  ggtgtgctc  atacccagc  gttcttcat  agtagtggg  2160
tatgcagga  cttctggga  atttttttg  gtcaaagac  taaagggcc  aatgaatta  2220
tatatacat  ctgcatctt  gttatttct  aaggtagca  tctttggag  taaaatgca  2280
atatagaca  atacaccca  acacttaca  caaactact  aatgaagaa  tattttggt  2340
accaggcca  ttttggtgg  aatccaaga  tggtctccc  tatgcagaa  tagacaaaa  2400
gtatattaa  caaagtttc  gagtatatt  ttgaagaga  agagacaag  aatttcagt  2460
taaagtgtg  gattgaagg  gataaggga  aagataaag  ccagaaatt  ccttttcac  2520
ttttcagga  aataactta  actctagta  ttatgggtg  atttatcct  ttgccttct  2580
gtatacttc  ttactttta  ggataaatc  taaagtcag  tgctcaaaa  gaaatcaat  2640
gttgaatta  tgagtatag  ggggttcca  gagttatca  gaattttaa  gtatgcatt  2700
ttaaattgt  aaactccaa  gtgatgttg  acctctttt  cttgccaaa  tacagaatt  2760
gaattatca  caaagaaaa  aaaaaaagc  agccaagct  taaattatg  gaccataat  2820
tactgattt  agtaagtct  ataggttaa  aaaaaaagt  accaaatag  gtgaaatat  2880
ttacttaac  gtccgtaag  agtatatta  tattatctt  ttcaggaaa  ggttgaata  2940
tatatgcct  gtgtaatat  gaaaattga  aagtacaac  aacgcaacc  agtgtgcta  3000
aaatgagct  gattaaatc  accacctat  tttgacatg  aaatgaagc  gggtttctt  3060
tcttcactc  aattttggc  aatctcaaa  ttagatcct  agatgtgtt  ttattttta  3120
aacatcttt  ttgaaattc  atttataat  cagaatctt  ttttgaaaa  aacctaatt  3180
atatattaa  attccaaat  catggcatg  ttaaatttt  actaaattt  aaagccatt  3240
tgattattg  gttccagtt  aagttagtg  aaatctgaa  attctcctg  ggaaggcag  3300
gaaatctaa  ctgtgtctg  ccaatgaat  atggaaaat  ccatgaatt  cctggatgt  3360
ctttttacg  ggtgacaag  gttggggac  gaactccca  tacaactga  caagtttct  3420
ttctagatg  ttttttgaa  gttaacatt  atgcctgct  tttggaaag  cagaatcag  3480
agatagtct  ggaagctgt  tggaaaaga  agtggagat  aggtcagtt  tgtttttta  3540
gatggcaat  actttggta  ctgggaaag  ataaagctc  aatgaaatg  atgcattca  3600
atttagaaa  gtgaattga  gtttcaagt  ttaaagttc  ttgcaatta  acttccaaa  3660
aaagttcta  agtgtccta  gtgctaagt  cttattaca  tttattaag  tttttggaa  3720
ctttgtacc  aaattttaa  aaagggagt  tttgatagt  gtgtgtatg  gtgtgtggg  3780
tggggggat  gtaagagaa  agagagaaa  actgaaaag  aggaaagat  gttaaacat  3840
ttcccactc  ttctgaatt  attaatttg  agcacaaaa  tcaaagcat  gacatttag  3900
agaaagatg  ttggcgtag  agagttaaa  ctcaaatag  ctattaaaa  agtctacaa  3960
atagcagat  tgttttgtg  tttggaata  taaaaaact  catgtaatt  tattttaaa  4020
tttcatagc  gtacttctt  aatataaaa  atcatgcca  tatttttaa  ggcattaga  4080
tcaactaca  aaagcaggc  tgcccagta  atttaaatt  tttggcact  gccattcca  4140
aatattatg  cccaccaag  ctgagacag  gaatttggg  tgctgtagc  tattttttt  4200
gattgagaa  tgtgtagct  caaaaataa  catgaacca  tctggatgc  tcattatgt  4260
aaccaggtc  agatgtgct  taatctgtt  ttacgtatg  aggcccagt  gtcatcaga  4320
gcttgcggc  aaagaaagc  gtgtttata  ggaagaaag  aaggtgctt  gagtttacc  4380
ggcttattt  atatgctta  aacctagtt  aagaaagga  aagaaaaca  aaaacgaat  4440
aaaataact  aatttggag  ctggagtaa  cagattact  ctttaatca  aaaccctca  4500
tgtgtttct  ccggagaga  aatgtattt  ctgacaacc  ttaaagtca  aagttttac  4560
ccaggttat  gcaataaag  ataatgttt  ttaaatgct  catttgtat  tcaaagctt  4620
gactctata  gcaaattgc  tttttccaa  acaaaaaga  gtctcaggt  tgttttgtg  4680
attttctaa  agctttcat  tcccagaac  tagccttta  ctgtgaagt  ttactacag  4740
cttaatatt  tcctagtag  tctatatta  atcaaatag  tgcatagca  tatatgtta  4800
tttgtgtgt  tttagctgt  acacaactg  gtgattaaa  ggtatactt  agtagacat  4860
tataactca  ggatacctt  ttatttaat  ttttcttat  tttgtactt  atcatgaat  4920
cttttagtg  gtgcataat  gctacagtg  atagttgta  acaaagtac  ttctgggga  4980
acaacattt  tatgtagcc  ttactgttt  atataccaa  ttaaaaaaa  attgtatct  5040
attacttat  ctgggacac  attaccaaa  taataaaaa  cactttcat  atcttgaaa  5100
aa  5102



<210> 8044
<211> 543
<212> PRT
<213> Homo sapiens
<308> Q16678
<400> 8044

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
  1               5                  10                  15
Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
             20                  25                  30
Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
         35                  40                  45
Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
     50                  55                  60
Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
 65                  70                  75                  80
Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                 85                  90                  95
Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
             100                105                110
Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
         115                120                125
Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
     130                135                140
Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
 145                150                155                160
Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                 165                170                175
Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
             180                185                190
Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
         195                200                205
Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
     210                215                220
Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
 225                230                235                240
Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                 245                250                255
Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
             260                265                270
Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
         275                280                285
Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
     290                295                300
Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
 305                310                315                320
Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                 325                330                335
Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
             340                345                350
Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
         355                360                365
Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
     370                375                380
Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
 385                390                395                400
His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                 405                410                415
Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Val 
             420                425                430
Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
         435                440                445
Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
     450                455                460
Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
 465                470                475                480
Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                 485                490                495
Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
             500                505                510
Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
         515                520                525
Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
     530                535                540



<210> 8045
<211> 4964
<212> DNA
<213> Rattus norvegicus
<308> U09540
<400> 8045

gttgcagac  cctctgcga  gccagcttg  aagccgccg  cgggctggg  tttagctcc  60
ctttatcaa  tcccaaccc  tcacccatc  caaccgcaa  tccaactct  tgagaaagt  120
ctgactttg  ggagcccca  gtgcactgg  gctcagcaa  cttgagaca  ttcccccct  180
tcctccatc  taatctaag  ttaggttct  actgagcca  gagtgggtg  taaagcagc  240
ggcctcagg  gtctaggac  ccgggtcct  ggggactct  aggttgaag  cttgcagag  300
ctgggcaga  gctccagag  ttctcccag  ccccactgc  ctacaccgc  ggaaccgcg  360
ttcatcgca  catggccac  agccttagt  cagacagtc  acagcagct  agctcgctg  420
ctacccaac  gaccattct  ctgctactc  tttcggtcc  ggccatcgt  cacttaggc  480
agtggctgc  gcgccagtg  cgacggaaa  cgtggtcct  gcccccggg  ccctttcct  540
ggccattga  cggaaacgc  gcgtctgtt  gccgggcat  gcacttgta  ttcgctcgc  600
ttgcgaggc  ctatggcga  gtttttcag  tccgtctgg  cagctgtcc  gtggtggtg  660
tgaatggcg  gagtgccat  catcaggct  tggtgcagc  gggcggcgt  tttgcggac  720
ggcctccct  cgcctcttt  cgtgtggtg  ctggtggcc  cagcctggc  ttcggccac  780
actcagagc  ctggaagga  cggcgacgt  cagcctatg  cacgatgcg  gccttctcc  840
cccgccacc  gcgcagccg  ggtctcctc  agggccacg  gctgggaga  gctcgagag  900
tggtggcag  gttggtgcg  cgctgcgcc  gtggcgcct  cctcgatcc  acgcagccg  960
tcatagtgg  ggtggctaa  gtcatgagc  ctgtatgct  cggctgtcg  tacaaccac  1020
acgatgccg  gttcctgga  ctgctcagc  acaacgagg  gttcgggcg  accgtgggc  1080
cgggcagcc  ggtggacgt  atgccctgg  tgcagcttt  tcccaaccc  gtgcgcacc  1140
tcttccgcg  gttcgagca  atcaaccgc  acttcagca  cttcgtcct  gacaagttc  1200
tgaggcacc  agaaagcct  gtgcccggg  ctgctcctc  agacatgat  gacgccttc  1260
tcctctccg  cgaaaagaa  gcgactggg  accctggtg  cagtccctc  gggctggat  1320
tggaggatg  gcctgccac  attacagac  tctttggag  cagccagga  accctttcc  1380
ccgcgctgc  gtggctgct  atcctcttt  ccagatacc  ggatgtgca  gcccgcgtg  1440
aggccgagt  ggaccaggt  gtggggagg  accgcctgc  ctgcatgag  gaccaaccc  1500
acttaccat  cgtcatggc  tttctttat  aatccatgc  attcaccag  tttttgcct  1560
tcacccttc  acatgccac  actgccaac  cctttgttt  aggctacta  atccccaaa  1620
acacggtag  ttttgttaa  cagtggtct  tgaatcatg  cccagcaaa  tggtctaac  1680
cagaggact  tgatccggc  cgcttcctg  acaaggacg  cttcattaa  aaggcacta  1740
ccagcagcg  gatgatatt  tcagtgggc  aacgacggt  catcggcga  gagttgtct  1800
agacgcttc  gtttctctt  atctccatc  tcgctcatc  gtgcaattt  aaggctaac  1860
aaaacgagc  ctcaaacat  agtttcagt  acggcctga  cattaagcc  aagtcgttt  1920
aaatccatg  gtctctcag  gagtccatg  agctccttg  tagtgctgt  gagaagctg  1980
aagctgagg  agcttgcca  tgagagagg  agaggccgg  ggtaactga  atgttcaaa  2040
aaaaccatc  cattaactg  agaggaaaa  acagatttt  ttttctcca  cttcatttt  2100
gcctcagtt  tcaagaatg  gcggaaacc  agtggcctg  aggtgaggc  ggcttacca  2160
ttcatggct  ctcaccggc  agcagctgg  gatcctgaa  tattttgaa  ttgaagagt  2220
atagggtcc  aggaatttg  atactgttc  cccctcacc  ccattaaac  catgcacac  2280
aatcagcat  tgtgtacag  tatccaaca  aatatttca  taactctgc  tttttgggt  2340
gatttgaaa  ggaacttct  ttgcagaaa  tggccccat  ggaaaccac  gtaagcaga  2400
gcttaggat  tatatatat  tatatatat  ttcaagatt  aaagaagtg  tttaagtgt  2460
aaatataaa  agcagaaat  taccaagag  caaatgagc  ctcccttgt  gccctggac  2520
aggttttct  tctgcctgt  gatgtgcct  ccactctag  acggaccat  aagccgttt  2580
gctccccct  aatttatgg  tagtttaat  accacagta  gttttagag  ttagtgaat  2640
caaaggtaa  ttgtttgaa  ggcaaaagg  ttttgtaag  taaaactgt  tgtcattca  2700
ctgttcaaa  gaagcattc  agttatgag  gagaaaaag  tttgccagt  taacgtaag  2760
tttcaactt  gggatcgta  caaactgat  tgagtaata  gtcggataa  gtaaaaaat  2820
aaaaagcct  atgtcacca  atagcattc  ataaatttt  cataattat  cacaagcat  2880
atatgaata  taactattt  acaggaaag  acttgaata  tacatttct  atgtcatct  2940
gcaaaccaa  aagtataat  agttgggtg  aatttgccc  aatccagga  acgatcctg  3000
caaaatcga  ctgattaat  tcagggaag  aagtaacag  acgatcctt  cctttctta  3060
ttacagccc  tacacgaga  aaatctcaa  actaaacca  caaaaccat  ctctgatct  3120
gtaattgta  ttacaacgc  cttttcttt  ggaattgac  cctttcggt  gcgttaaga  3180
tccaaactc  tggctggct  tgattttaa  ttagtttaa  atccacctt  attattttg  3240
ttcggttga  gctggagaa  gtatggtta  tatctcaca  aaggtgaga  acctaacct  3300
tatctaagg  caaatgtca  aggcaacaa  caatcaaac  aacaaacaa  gccatgagt  3360
ctctgggtg  tcttattag  cgccctctg  caagaaact  agtaccact  gtagttggt  3420
gtttctttt  atgtgctat  actatggtt  ttgtaggtg  tttttaaat  gagtattaa  3480
gtctgcggt  ttgtgtttt  ttttaagtc  gaatctgaa  attgtcttg  gaggttgtt  3540
agcgactgc  tggggagac  gcagagacg  ctaaaattg  ctcttattt  ggatggcag  3600
ctgagcagc  gccttcctg  tagctgaga  aggagaaat  tatgtattt  gattgtgta  3660
acaatccga  acctgttaa  aagggttgg  tgagtggaa  agtagggac  gggcgcgtg  3720
ggggtttcc  atttctgtt  tcactgcaa  ttagacgga  caaaagaag  ccacggcac  3780
cagagagct  atggttggc  ctgtttcat  aggcttctt  gaattttcc  atcaaaatt  3840
caaaggaag  agtgtgtga  attcttgtg  gcagaggcc  gaagctgac  gacagagag  3900
gcatgagca  gagagaaat  tttaaatgg  ccccattca  tccaaatta  tctcttgac  3960
tgtaacatt  gaggcatga  gtttagaaa  aaaggagtt  caagggtca  gtcttacct  4020
caagtgtct  ttaagactg  ctggagacc  agccctcac  ctctctctc  cccatccac  4080
tctattttg  agttggaga  tgaattata  aaaatataa  gtaatcctt  tttaaattt  4140
tcacaacag  accccttga  tgtgaaaca  aggttgtgt  agtattttc  aggccttga  4200
ttcaactac  aaaattaac  ctgtaaaca  ttttaagtt  ttcagacat  ttaaaagca  4260
gcacctcag  aaggtcggg  cagtgattt  agcctccat  gcctcttta  tatgagaaa  4320
ttgtaagag  gaaaagtct  catgaacca  tctggactc  tcattaagc  aaccagacc  4380
agatgtttt  tgaacgtag  ggtcatgtt  gtctgatgc  ttcagcaaa  gggaaagaa  4440
ggggctact  tgtatatat  tagacccag  gaaaggaag  aggatacaa  tcaggaaag  4500
gtaacaatt  tcatattcg  aagctaata  attactggc  tagttggaa  gcctgcctt  4560
ttctgctac  gagggattt  ttttgctgg  caccatctt  atcagagta  ccacctcct  4620
tcagggcag  caaaaagta  gtttttatt  aatgtctcc  ttgcacagt  aagcttgga  4680
tatgtcaga  cgttgcttt  ttttttaaa  caaaaaata  gcctcaggt  tgttttatg  4740
attactcaa  agagttcat  ccccagaac  tagcctgta  ctgtgaaat  ttatcatgc  4800
ccttatgta  tcacaccag  gctgtgcta  attaaatag  gatcatcac  atggtatgc  4860
aattactgt  tttagcagt  acacagttg  gtgacagaa  gtgtatgtt  ccaggtgat  4920
ataacccag  aataattcc  tatttaacc  ctaaaaaaa  aaaa  4964



<210> 8046
<211> 543
<212> PRT
<213> Rattus norvegicus
<308> Q64678
<400> 8046

Met Ala Thr Ser Leu Ser Ala Asp Ser Pro Gln Gln Leu Ser Ser Leu 
  1               5                  10                  15
Ser Thr Gln Gln Thr Ile Leu Leu Leu Leu Val Ser Val Leu Ala Ile 
             20                  25                  30
Val His Leu Gly Gln Trp Leu Leu Arg Gln Trp Arg Arg Lys Pro Trp 
         35                  40                  45
Ser Ser Pro Pro Gly Pro Phe Pro Trp Pro Leu Ile Gly Asn Ala Ala 
     50                  55                  60
Ser Val Gly Arg Ala Ser His Leu Tyr Phe Ala Arg Leu Ala Arg Arg 
 65                  70                  75                  80
Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Val Val Val 
                 85                  90                  95
Leu Asn Gly Glu Ser Ala Ile His Gln Ala Leu Val Gln Gln Gly Gly 
             100                105                110
Val Phe Ala Asp Arg Pro Pro Phe Ala Ser Phe Arg Val Val Ser Gly 
         115                120                125
Gly Arg Ser Leu Ala Phe Gly His Tyr Ser Glu Arg Trp Lys Glu Arg 
     130                135                140
Arg Arg Ala Ala Tyr Gly Thr Met Arg Ala Phe Ser Thr Arg His Pro 
 145                150                155                160
Arg Ser Arg Gly Leu Leu Glu Gly His Ala Leu Gly Glu Ala Arg Glu 
                 165                170                175
Leu Val Ala Val Leu Val Arg Arg Cys Ala Gly Gly Ala Cys Leu Asp 
             180                185                190
Pro Thr Gln Pro Ile Ile Val Ala Val Ala Asn Val Met Ser Ala Val 
         195                200                205
Cys Phe Gly Cys Arg Tyr Asn His Asp Asp Ala Glu Phe Leu Glu Leu 
     210                215                220
Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
 225                230                235                240
Val Asp Val Met Pro Trp Leu Gln Leu Phe Pro Asn Pro Val Arg Thr 
                 245                250                255
Ile Phe Arg Glu Phe Glu Gln Ile Asn Arg Asn Phe Ser Asn Phe Val 
             260                265                270
Leu Asp Lys Phe Leu Arg His Arg Glu Ser Leu Val Pro Gly Ala Ala 
         275                280                285
Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
     290                295                300
Thr Gly Asp Pro Gly Asp Ser Pro Ser Gly Leu Asp Leu Glu Asp Val 
 305                310                315                320
Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                 325                330                335
Thr Ala Leu Leu Trp Leu Leu Ile Leu Phe Thr Arg Tyr Pro Asp Val 
             340                345                350
Gln Ala Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
         355                360                365
Leu Pro Cys Met Ser Asp Gln Pro Asn Leu Pro Tyr Val Met Ala Phe 
     370                375                380
Leu Tyr Glu Ser Met Arg Phe Thr Ser Phe Leu Pro Val Thr Leu Pro 
 385                390                395                400
His Ala Thr Thr Ala Asn Thr Phe Val Leu Gly Tyr Tyr Ile Pro Lys 
                 405                410                415
Asn Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Ala 
             420                425                430
Lys Trp Ser Asn Pro Glu Asp Phe Asp Pro Ala Arg Phe Leu Asp Lys 
         435                440                445
Asp Gly Phe Ile Asn Lys Ala Leu Ala Ser Ser Val Met Ile Phe Ser 
     450                455                460
Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Thr Leu Leu 
 465                470                475                480
Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asn Phe Lys Ala Asn 
                 485                490                495
Gln Asn Glu Pro Ser Asn Met Ser Phe Ser Tyr Gly Leu Ser Ile Lys 
             500                505                510
Pro Lys Ser Phe Lys Ile His Val Ser Leu Arg Glu Ser Met Lys Leu 
         515                520                525
Leu Asp Ser Ala Val Glu Lys Leu Gln Ala Glu Glu Ala Cys Gln 
     530                535                540



<210> 8047
<211> 5102
<212> DNA
<213> Homo sapiens
<308> U03688
<400> 8047

gcttctgcg  ctccagttg  gagagccgc  agggcatgg  aattgacgc  actcaccga  60
ccccagtct  aatctcaac  ctgtgagga  acctcgact  tgccaggtc  ccaagggca  120
cggggctcg  cgagcgagg  acccttctc  gtccccatc  caatccaag  gctcctggc  180
ctgacgacg  caagagact  gagtgggag  taaagcttc  agtgagggc  gcaggtgtc  240
aggccgggc  tgcgggttc  tgttgacgt  ttgccctag  caaaggtcc  agttccttc  300
cggagccgg  tgtcccgcg  cactggaaa  cgcacctcc  cgcagcatg  gcaccagcc  360
cagcccgaa  gacccttgg  cgctaaacc  gctgtccat  cagcagacc  cgctcctgc  420
actcctgtc  gtgctggcc  ctgtgcatg  gggccagcg  ctgctgagg  aacggaggc  480
gcagctccg  tccgcgccc  cgggcccgt  tgcgtggcc  ctgatcgga  acgcggcgg  540
ggtgggcca  gcggctcac  tctcgttcg  tcgcctggc  cggcgctac  gcgacgttt  600
ccagatccg  ctgggcagc  gccccatag  ggtgctgaa  ggcgagcgc  ccatccacc  660
ggccctggt  cagcagggc  cggccttcg  cgaccggcc  gccttcgcc  ccttccgtg  720
ggtgtccgg  ggccgcagc  tggctttcg  ccactactc  gagcactgg  aggtgcagc  780
gcgcgcagc  cacagcatg  tgcgcaact  cttcacgcg  cagccgcgc  gccgccaag  840
cctcgaggg  cacgtgctg  gcgaggcgc  cgagctggt  gcgctgctg  tgcgcggca  900
cgcggacgg  gccttcctc  acccgaggc  gctgaccgt  gtggccgtg  ccaacgtca  960
gagtgccgt  tgtttcggc  gccgctaca  ccacgacga  cccgagttc  gtgagctgc  1020
cagccacaa  gaagagttc  ggcgcacgg  gggcgcggg  agcctggtg  acgtgatgc  1080
ctggctgca  tacttcccc  acccggtgc  caccgtttt  cgcgaattc  agcagctca  1140
ccgcaactt  agcaacttc  tcctggaca  gttcttgag  cactgcgaa  gccttcggc  1200
cggggccgc  ccccgcgac  tgatggacg  ctttatcct  tctgcggaa  agaaggcgg  1260
cggggactc  cacggtggt  gcgcgcggc  ggatttgga  aacgtaccg  ccactatca  1320
tgacatctt  ggcgccagc  aggacaccc  gtccaccgc  ctgcagtgg  tgctcctcc  1380
cttcaccag  tatcctgat  tgcagactc  agtgcaggc  gaattggat  aggtcgtgg  1440
gagggaccg  ctgccttgt  tgggtgacc  gcccaacct  ccctatgtc  tggccttcc  1500
ttatgaagc  atgcgcttc  ccagctttg  gcctgtcac  attcctcat  ccaccactg  1560
caacacctc  gtcttgggc  accacattc  caaggacac  gtggttttt  tcaaccagt  1620
gtctgtgaa  catgaccca  tgaagtggc  taacccgga  aactttgat  cagctcgat  1680
cttggacaa  gatggcctc  tcaacaagg  cctgaccag  agagtgatg  ttttttcag  1740
gggcaaaag  cggtgcatt  gcgaagaac  ttctaagat  cagcttttt  tcttcatct  1800
catcctggc  caccagtgc  atttcaggg  caacccaaa  gagcctgcg  aaatgaatt  1860
cagttatgg  ctaaccatt  aacccaagt  atttaaagt  aatgtcact  tcagagagt  1920
catggagct  cttgatagt  ctgtccaaa  tttacaagc  aaggaaact  gccaataag  1980
agcaagagg  aagctgaaa  tttagaaat  ttcacatct  cggagatga  gagtaaaat  2040
cagtttttt  ccagttcct  ttttgtgct  cttctcaat  agcgtttaa  gtgagcata  2100
atcaactgt  catcaggtg  ggtgtgctc  atacccagc  gttcttcat  agtagtggg  2160
tatgcagga  cttctggga  atttttttg  gtcaaagac  taaagggcc  aatgaatta  2220
tatatacat  ctgcatctt  gttatttct  aaggtagca  tctttggag  taaaatgca  2280
atatagaca  atacaccca  acacttaca  caaactact  aatgaagaa  tattttggt  2340
accaggcca  ttttggtgg  aatccaaga  tggtctccc  tatgcagaa  tagacaaaa  2400
gtatattaa  caaagtttc  gagtatatt  ttgaagaga  agagacaag  aatttcagt  2460
taaagtgtg  gattgaagg  gataaggga  aagataaag  ccagaaatt  ccttttcac  2520
ttttcagga  aataactta  actctagta  ttatgggtg  atttatcct  ttgccttct  2580
gtatacttc  ttactttta  ggataaatc  taaagtcag  tgctcaaaa  gaaatcaat  2640
gttgaatta  tgagtatag  ggggttcca  gagttatca  gaattttaa  gtatgcatt  2700
ttaaattgt  aaactccaa  gtgatgttg  acctctttt  cttgccaaa  tacagaatt  2760
gaattatca  caaagaaaa  aaaaaaagc  agccaagct  taaattatg  gaccataat  2820
tactgattt  agtaagtct  ataggttaa  aaaaaaagt  accaaatag  gtgaaatat  2880
ttacttaac  gtccgtaag  agtatatta  tattatctt  ttcaggaaa  ggttgaata  2940
tatatgcct  gtgtaatat  gaaaattga  aagtacaac  aacgcaacc  agtgtgcta  3000
aaatgagct  gattaaatc  accacctat  tttgacatg  aaatgaagc  gggtttctt  3060
tcttcactc  aattttggc  aatctcaaa  ttagatcct  agatgtgtt  ttattttta  3120
aacatcttt  ttgaaattc  atttataat  cagaatctt  ttttgaaaa  aacctaatt  3180
atatattaa  attccaaat  catggcatg  ttaaatttt  actaaattt  aaagccatt  3240
tgattattg  gttccagtt  aagttagtg  aaatctgaa  attctcctg  ggaaggcag  3300
gaaatctaa  ctgtgtctg  ccaatgaat  atggaaaat  ccatgaatt  cctggatgt  3360
ctttttacg  ggtgacaag  gttggggac  gaactccca  tacaactga  caagtttct  3420
ttctagatg  ttttttgaa  gttaacatt  atgcctgct  tttggaaag  cagaatcag  3480
agatagtct  ggaagctgt  tggaaaaga  agtggagat  aggtcagtt  tgtttttta  3540
gatggcaat  actttggta  ctgggaaag  ataaagctc  aatgaaatg  atgcattca  3600
atttagaaa  gtgaattga  gtttcaagt  ttaaagttc  ttgcaatta  acttccaaa  3660
aaagttcta  agtgtccta  gtgctaagt  cttattaca  tttattaag  tttttggaa  3720
ctttgtacc  aaattttaa  aaagggagt  tttgatagt  gtgtgtatg  gtgtgtggg  3780
tggggggat  gtaagagaa  agagagaaa  actgaaaag  aggaaagat  gttaaacat  3840
ttcccactc  ttctgaatt  attaatttg  agcacaaaa  tcaaagcat  gacatttag  3900
agaaagatg  ttggcgtag  agagttaaa  ctcaaatag  ctattaaaa  agtctacaa  3960
atagcagat  tgttttgtg  tttggaata  taaaaaact  catgtaatt  tattttaaa  4020
tttcatagc  gtacttctt  aatataaaa  atcatgcca  tatttttaa  ggcattaga  4080
tcaactaca  aaagcaggc  tgcccagta  atttaaatt  tttggcact  gccattcca  4140
aatattatg  cccaccaag  ctgagacag  gaatttggg  tgctgtagc  tattttttt  4200
gattgagaa  tgtgtagct  caaaaataa  catgaacca  tctggatgc  tcattatgt  4260
aaccaggtc  agatgtgct  taatctgtt  ttacgtatg  aggcccagt  gtcatcaga  4320
gcttgcggc  aaagaaagc  gtgtttata  ggaagaaag  aaggtgctt  gagtttacc  4380
ggcttattt  atatgctta  aacctagtt  aagaaagga  aagaaaaca  aaaacgaat  4440
aaaataact  aatttggag  ctggagtaa  cagattact  ctttaatca  aaaccctca  4500
tgtgtttct  ccggagaga  aatgtattt  ctgacaacc  ttaaagtca  aagttttac  4560
ccaggttat  gcaataaag  ataatgttt  ttaaatgct  catttgtat  tcaaagctt  4620
gactctata  gcaaattgc  tttttccaa  acaaaaaga  gtctcaggt  tgttttgtg  4680
attttctaa  agctttcat  tcccagaac  tagccttta  ctgtgaagt  ttactacag  4740
cttaatatt  tcctagtag  tctatatta  atcaaatag  tgcatagca  tatatgtta  4800
tttgtgtgt  tttagctgt  acacaactg  gtgattaaa  ggtatactt  agtagacat  4860
tataactca  ggatacctt  ttatttaat  ttttcttat  tttgtactt  atcatgaat  4920
cttttagtg  gtgcataat  gctacagtg  atagttgta  acaaagtac  ttctgggga  4980
acaacattt  tatgtagcc  ttactgttt  atataccaa  ttaaaaaaa  attgtatct  5040
attacttat  ctgggacac  attaccaaa  taataaaaa  cactttcat  atcttgaaa  5100
aa  5102



<210> 8048
<211> 543
<212> PRT
<213> Homo sapiens
<308> Q16678
<400> 8048

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
  1               5                  10                  15
Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
             20                  25                  30
Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
         35                  40                  45
Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
     50                  55                  60
Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
 65                  70                  75                  80
Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                 85                  90                  95
Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
             100                105                110
Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
         115                120                125
Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
     130                135                140
Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
 145                150                155                160
Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                 165                170                175
Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
             180                185                190
Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
         195                200                205
Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
     210                215                220
Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
 225                230                235                240
Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                 245                250                255
Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
             260                265                270
Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
         275                280                285
Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
     290                295                300
Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
 305                310                315                320
Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                 325                330                335
Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
             340                345                350
Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
         355                360                365
Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
     370                375                380
Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
 385                390                395                400
His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                 405                410                415
Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Val 
             420                425                430
Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
         435                440                445
Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
     450                455                460
Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
 465                470                475                480
Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                 485                490                495
Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
             500                505                510
Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
         515                520                525
Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
     530                535                540



<210> 8049
<211> 4964
<212> DNA
<213> Rattus norvegicus
<308> U09540
<400> 8049

gttgcagac  cctctgcga  gccagcttg  aagccgccg  cgggctggg  tttagctcc  60
ctttatcaa  tcccaaccc  tcacccatc  caaccgcaa  tccaactct  tgagaaagt  120
ctgactttg  ggagcccca  gtgcactgg  gctcagcaa  cttgagaca  ttcccccct  180
tcctccatc  taatctaag  ttaggttct  actgagcca  gagtgggtg  taaagcagc  240
ggcctcagg  gtctaggac  ccgggtcct  ggggactct  aggttgaag  cttgcagag  300
ctgggcaga  gctccagag  ttctcccag  ccccactgc  ctacaccgc  ggaaccgcg  360
ttcatcgca  catggccac  agccttagt  cagacagtc  acagcagct  agctcgctg  420
ctacccaac  gaccattct  ctgctactc  tttcggtcc  ggccatcgt  cacttaggc  480
agtggctgc  gcgccagtg  cgacggaaa  cgtggtcct  gcccccggg  ccctttcct  540
ggccattga  cggaaacgc  gcgtctgtt  gccgggcat  gcacttgta  ttcgctcgc  600
ttgcgaggc  ctatggcga  gtttttcag  tccgtctgg  cagctgtcc  gtggtggtg  660
tgaatggcg  gagtgccat  catcaggct  tggtgcagc  gggcggcgt  tttgcggac  720
ggcctccct  cgcctcttt  cgtgtggtg  ctggtggcc  cagcctggc  ttcggccac  780
actcagagc  ctggaagga  cggcgacgt  cagcctatg  cacgatgcg  gccttctcc  840
cccgccacc  gcgcagccg  ggtctcctc  agggccacg  gctgggaga  gctcgagag  900
tggtggcag  gttggtgcg  cgctgcgcc  gtggcgcct  cctcgatcc  acgcagccg  960
tcatagtgg  ggtggctaa  gtcatgagc  ctgtatgct  cggctgtcg  tacaaccac  1020
acgatgccg  gttcctgga  ctgctcagc  acaacgagg  gttcgggcg  accgtgggc  1080
cgggcagcc  ggtggacgt  atgccctgg  tgcagcttt  tcccaaccc  gtgcgcacc  1140
tcttccgcg  gttcgagca  atcaaccgc  acttcagca  cttcgtcct  gacaagttc  1200
tgaggcacc  agaaagcct  gtgcccggg  ctgctcctc  agacatgat  gacgccttc  1260
tcctctccg  cgaaaagaa  gcgactggg  accctggtg  cagtccctc  gggctggat  1320
tggaggatg  gcctgccac  attacagac  tctttggag  cagccagga  accctttcc  1380
ccgcgctgc  gtggctgct  atcctcttt  ccagatacc  ggatgtgca  gcccgcgtg  1440
aggccgagt  ggaccaggt  gtggggagg  accgcctgc  ctgcatgag  gaccaaccc  1500
acttaccat  cgtcatggc  tttctttat  aatccatgc  attcaccag  tttttgcct  1560
tcacccttc  acatgccac  actgccaac  cctttgttt  aggctacta  atccccaaa  1620
acacggtag  ttttgttaa  cagtggtct  tgaatcatg  cccagcaaa  tggtctaac  1680
cagaggact  tgatccggc  cgcttcctg  acaaggacg  cttcattaa  aaggcacta  1740
ccagcagcg  gatgatatt  tcagtgggc  aacgacggt  catcggcga  gagttgtct  1800
agacgcttc  gtttctctt  atctccatc  tcgctcatc  gtgcaattt  aaggctaac  1860
aaaacgagc  ctcaaacat  agtttcagt  acggcctga  cattaagcc  aagtcgttt  1920
aaatccatg  gtctctcag  gagtccatg  agctccttg  tagtgctgt  gagaagctg  1980
aagctgagg  agcttgcca  tgagagagg  agaggccgg  ggtaactga  atgttcaaa  2040
aaaaccatc  cattaactg  agaggaaaa  acagatttt  ttttctcca  cttcatttt  2100
gcctcagtt  tcaagaatg  gcggaaacc  agtggcctg  aggtgaggc  ggcttacca  2160
ttcatggct  ctcaccggc  agcagctgg  gatcctgaa  tattttgaa  ttgaagagt  2220
atagggtcc  aggaatttg  atactgttc  cccctcacc  ccattaaac  catgcacac  2280
aatcagcat  tgtgtacag  tatccaaca  aatatttca  taactctgc  tttttgggt  2340
gatttgaaa  ggaacttct  ttgcagaaa  tggccccat  ggaaaccac  gtaagcaga  2400
gcttaggat  tatatatat  tatatatat  ttcaagatt  aaagaagtg  tttaagtgt  2460
aaatataaa  agcagaaat  taccaagag  caaatgagc  ctcccttgt  gccctggac  2520
aggttttct  tctgcctgt  gatgtgcct  ccactctag  acggaccat  aagccgttt  2580
gctccccct  aatttatgg  tagtttaat  accacagta  gttttagag  ttagtgaat  2640
caaaggtaa  ttgtttgaa  ggcaaaagg  ttttgtaag  taaaactgt  tgtcattca  2700
ctgttcaaa  gaagcattc  agttatgag  gagaaaaag  tttgccagt  taacgtaag  2760
tttcaactt  gggatcgta  caaactgat  tgagtaata  gtcggataa  gtaaaaaat  2820
aaaaagcct  atgtcacca  atagcattc  ataaatttt  cataattat  cacaagcat  2880
atatgaata  taactattt  acaggaaag  acttgaata  tacatttct  atgtcatct  2940
gcaaaccaa  aagtataat  agttgggtg  aatttgccc  aatccagga  acgatcctg  3000
caaaatcga  ctgattaat  tcagggaag  aagtaacag  acgatcctt  cctttctta  3060
ttacagccc  tacacgaga  aaatctcaa  actaaacca  caaaaccat  ctctgatct  3120
gtaattgta  ttacaacgc  cttttcttt  ggaattgac  cctttcggt  gcgttaaga  3180
tccaaactc  tggctggct  tgattttaa  ttagtttaa  atccacctt  attattttg  3240
ttcggttga  gctggagaa  gtatggtta  tatctcaca  aaggtgaga  acctaacct  3300
tatctaagg  caaatgtca  aggcaacaa  caatcaaac  aacaaacaa  gccatgagt  3360
ctctgggtg  tcttattag  cgccctctg  caagaaact  agtaccact  gtagttggt  3420
gtttctttt  atgtgctat  actatggtt  ttgtaggtg  tttttaaat  gagtattaa  3480
gtctgcggt  ttgtgtttt  ttttaagtc  gaatctgaa  attgtcttg  gaggttgtt  3540
agcgactgc  tggggagac  gcagagacg  ctaaaattg  ctcttattt  ggatggcag  3600
ctgagcagc  gccttcctg  tagctgaga  aggagaaat  tatgtattt  gattgtgta  3660
acaatccga  acctgttaa  aagggttgg  tgagtggaa  agtagggac  gggcgcgtg  3720
ggggtttcc  atttctgtt  tcactgcaa  ttagacgga  caaaagaag  ccacggcac  3780
cagagagct  atggttggc  ctgtttcat  aggcttctt  gaattttcc  atcaaaatt  3840
caaaggaag  agtgtgtga  attcttgtg  gcagaggcc  gaagctgac  gacagagag  3900
gcatgagca  gagagaaat  tttaaatgg  ccccattca  tccaaatta  tctcttgac  3960
tgtaacatt  gaggcatga  gtttagaaa  aaaggagtt  caagggtca  gtcttacct  4020
caagtgtct  ttaagactg  ctggagacc  agccctcac  ctctctctc  cccatccac  4080
tctattttg  agttggaga  tgaattata  aaaatataa  gtaatcctt  tttaaattt  4140
tcacaacag  accccttga  tgtgaaaca  aggttgtgt  agtattttc  aggccttga  4200
ttcaactac  aaaattaac  ctgtaaaca  ttttaagtt  ttcagacat  ttaaaagca  4260
gcacctcag  aaggtcggg  cagtgattt  agcctccat  gcctcttta  tatgagaaa  4320
ttgtaagag  gaaaagtct  catgaacca  tctggactc  tcattaagc  aaccagacc  4380
agatgtttt  tgaacgtag  ggtcatgtt  gtctgatgc  ttcagcaaa  gggaaagaa  4440
ggggctact  tgtatatat  tagacccag  gaaaggaag  aggatacaa  tcaggaaag  4500
gtaacaatt  tcatattcg  aagctaata  attactggc  tagttggaa  gcctgcctt  4560
ttctgctac  gagggattt  ttttgctgg  caccatctt  atcagagta  ccacctcct  4620
tcagggcag  caaaaagta  gtttttatt  aatgtctcc  ttgcacagt  aagcttgga  4680
tatgtcaga  cgttgcttt  ttttttaaa  caaaaaata  gcctcaggt  tgttttatg  4740
attactcaa  agagttcat  ccccagaac  tagcctgta  ctgtgaaat  ttatcatgc  4800
ccttatgta  tcacaccag  gctgtgcta  attaaatag  gatcatcac  atggtatgc  4860
aattactgt  tttagcagt  acacagttg  gtgacagaa  gtgtatgtt  ccaggtgat  4920
ataacccag  aataattcc  tatttaacc  ctaaaaaaa  aaaa  4964



<210> 8050
<211> 543
<212> PRT
<213> Rattus norvegicus
<308> Q64678
<400> 8050

Met Ala Thr Ser Leu Ser Ala Asp Ser Pro Gln Gln Leu Ser Ser Leu 
  1               5                  10                  15
Ser Thr Gln Gln Thr Ile Leu Leu Leu Leu Val Ser Val Leu Ala Ile 
             20                  25                  30
Val His Leu Gly Gln Trp Leu Leu Arg Gln Trp Arg Arg Lys Pro Trp 
         35                  40                  45
Ser Ser Pro Pro Gly Pro Phe Pro Trp Pro Leu Ile Gly Asn Ala Ala 
     50                  55                  60
Ser Val Gly Arg Ala Ser His Leu Tyr Phe Ala Arg Leu Ala Arg Arg 
 65                  70                  75                  80
Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Val Val Val 
                 85                  90                  95
Leu Asn Gly Glu Ser Ala Ile His Gln Ala Leu Val Gln Gln Gly Gly 
             100                105                110
Val Phe Ala Asp Arg Pro Pro Phe Ala Ser Phe Arg Val Val Ser Gly 
         115                120                125
Gly Arg Ser Leu Ala Phe Gly His Tyr Ser Glu Arg Trp Lys Glu Arg 
     130                135                140
Arg Arg Ala Ala Tyr Gly Thr Met Arg Ala Phe Ser Thr Arg His Pro 
 145                150                155                160
Arg Ser Arg Gly Leu Leu Glu Gly His Ala Leu Gly Glu Ala Arg Glu 
                 165                170                175
Leu Val Ala Val Leu Val Arg Arg Cys Ala Gly Gly Ala Cys Leu Asp 
             180                185                190
Pro Thr Gln Pro Ile Ile Val Ala Val Ala Asn Val Met Ser Ala Val 
         195                200                205
Cys Phe Gly Cys Arg Tyr Asn His Asp Asp Ala Glu Phe Leu Glu Leu 
     210                215                220
Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
 225                230                235                240
Val Asp Val Met Pro Trp Leu Gln Leu Phe Pro Asn Pro Val Arg Thr 
                 245                250                255
Ile Phe Arg Glu Phe Glu Gln Ile Asn Arg Asn Phe Ser Asn Phe Val 
             260                265                270
Leu Asp Lys Phe Leu Arg His Arg Glu Ser Leu Val Pro Gly Ala Ala 
         275                280                285
Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
     290                295                300
Thr Gly Asp Pro Gly Asp Ser Pro Ser Gly Leu Asp Leu Glu Asp Val 
 305                310                315                320
Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                 325                330                335
Thr Ala Leu Leu Trp Leu Leu Ile Leu Phe Thr Arg Tyr Pro Asp Val 
             340                345                350
Gln Ala Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
         355                360                365
Leu Pro Cys Met Ser Asp Gln Pro Asn Leu Pro Tyr Val Met Ala Phe 
     370                375                380
Leu Tyr Glu Ser Met Arg Phe Thr Ser Phe Leu Pro Val Thr Leu Pro 
 385                390                395                400
His Ala Thr Thr Ala Asn Thr Phe Val Leu Gly Tyr Tyr Ile Pro Lys 
                 405                410                415
Asn Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Ala 
             420                425                430
Lys Trp Ser Asn Pro Glu Asp Phe Asp Pro Ala Arg Phe Leu Asp Lys 
         435                440                445
Asp Gly Phe Ile Asn Lys Ala Leu Ala Ser Ser Val Met Ile Phe Ser 
     450                455                460
Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Thr Leu Leu 
 465                470                475                480
Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asn Phe Lys Ala Asn 
                 485                490                495
Gln Asn Glu Pro Ser Asn Met Ser Phe Ser Tyr Gly Leu Ser Ile Lys 
             500                505                510
Pro Lys Ser Phe Lys Ile His Val Ser Leu Arg Glu Ser Met Lys Leu 
         515                520                525
Leu Asp Ser Ala Val Glu Lys Leu Gln Ala Glu Glu Ala Cys Gln 
     530                535                540



<210> 8051
<211> 5102
<212> DNA
<213> Homo sapiens
<308> U03688
<400> 8051

gcttctgcg  ctccagttg  gagagccgc  agggcatgg  aattgacgc  actcaccga  60
ccccagtct  aatctcaac  ctgtgagga  acctcgact  tgccaggtc  ccaagggca  120
cggggctcg  cgagcgagg  acccttctc  gtccccatc  caatccaag  gctcctggc  180
ctgacgacg  caagagact  gagtgggag  taaagcttc  agtgagggc  gcaggtgtc  240
aggccgggc  tgcgggttc  tgttgacgt  ttgccctag  caaaggtcc  agttccttc  300
cggagccgg  tgtcccgcg  cactggaaa  cgcacctcc  cgcagcatg  gcaccagcc  360
cagcccgaa  gacccttgg  cgctaaacc  gctgtccat  cagcagacc  cgctcctgc  420
actcctgtc  gtgctggcc  ctgtgcatg  gggccagcg  ctgctgagg  aacggaggc  480
gcagctccg  tccgcgccc  cgggcccgt  tgcgtggcc  ctgatcgga  acgcggcgg  540
ggtgggcca  gcggctcac  tctcgttcg  tcgcctggc  cggcgctac  gcgacgttt  600
ccagatccg  ctgggcagc  gccccatag  ggtgctgaa  ggcgagcgc  ccatccacc  660
ggccctggt  cagcagggc  cggccttcg  cgaccggcc  gccttcgcc  ccttccgtg  720
ggtgtccgg  ggccgcagc  tggctttcg  ccactactc  gagcactgg  aggtgcagc  780
gcgcgcagc  cacagcatg  tgcgcaact  cttcacgcg  cagccgcgc  gccgccaag  840
cctcgaggg  cacgtgctg  gcgaggcgc  cgagctggt  gcgctgctg  tgcgcggca  900
cgcggacgg  gccttcctc  acccgaggc  gctgaccgt  gtggccgtg  ccaacgtca  960
gagtgccgt  tgtttcggc  gccgctaca  ccacgacga  cccgagttc  gtgagctgc  1020
cagccacaa  gaagagttc  ggcgcacgg  gggcgcggg  agcctggtg  acgtgatgc  1080
ctggctgca  tacttcccc  acccggtgc  caccgtttt  cgcgaattc  agcagctca  1140
ccgcaactt  agcaacttc  tcctggaca  gttcttgag  cactgcgaa  gccttcggc  1200
cggggccgc  ccccgcgac  tgatggacg  ctttatcct  tctgcggaa  agaaggcgg  1260
cggggactc  cacggtggt  gcgcgcggc  ggatttgga  aacgtaccg  ccactatca  1320
tgacatctt  ggcgccagc  aggacaccc  gtccaccgc  ctgcagtgg  tgctcctcc  1380
cttcaccag  tatcctgat  tgcagactc  agtgcaggc  gaattggat  aggtcgtgg  1440
gagggaccg  ctgccttgt  tgggtgacc  gcccaacct  ccctatgtc  tggccttcc  1500
ttatgaagc  atgcgcttc  ccagctttg  gcctgtcac  attcctcat  ccaccactg  1560
caacacctc  gtcttgggc  accacattc  caaggacac  gtggttttt  tcaaccagt  1620
gtctgtgaa  catgaccca  tgaagtggc  taacccgga  aactttgat  cagctcgat  1680
cttggacaa  gatggcctc  tcaacaagg  cctgaccag  agagtgatg  ttttttcag  1740
gggcaaaag  cggtgcatt  gcgaagaac  ttctaagat  cagcttttt  tcttcatct  1800
catcctggc  caccagtgc  atttcaggg  caacccaaa  gagcctgcg  aaatgaatt  1860
cagttatgg  ctaaccatt  aacccaagt  atttaaagt  aatgtcact  tcagagagt  1920
catggagct  cttgatagt  ctgtccaaa  tttacaagc  aaggaaact  gccaataag  1980
agcaagagg  aagctgaaa  tttagaaat  ttcacatct  cggagatga  gagtaaaat  2040
cagtttttt  ccagttcct  ttttgtgct  cttctcaat  agcgtttaa  gtgagcata  2100
atcaactgt  catcaggtg  ggtgtgctc  atacccagc  gttcttcat  agtagtggg  2160
tatgcagga  cttctggga  atttttttg  gtcaaagac  taaagggcc  aatgaatta  2220
tatatacat  ctgcatctt  gttatttct  aaggtagca  tctttggag  taaaatgca  2280
atatagaca  atacaccca  acacttaca  caaactact  aatgaagaa  tattttggt  2340
accaggcca  ttttggtgg  aatccaaga  tggtctccc  tatgcagaa  tagacaaaa  2400
gtatattaa  caaagtttc  gagtatatt  ttgaagaga  agagacaag  aatttcagt  2460
taaagtgtg  gattgaagg  gataaggga  aagataaag  ccagaaatt  ccttttcac  2520
ttttcagga  aataactta  actctagta  ttatgggtg  atttatcct  ttgccttct  2580
gtatacttc  ttactttta  ggataaatc  taaagtcag  tgctcaaaa  gaaatcaat  2640
gttgaatta  tgagtatag  ggggttcca  gagttatca  gaattttaa  gtatgcatt  2700
ttaaattgt  aaactccaa  gtgatgttg  acctctttt  cttgccaaa  tacagaatt  2760
gaattatca  caaagaaaa  aaaaaaagc  agccaagct  taaattatg  gaccataat  2820
tactgattt  agtaagtct  ataggttaa  aaaaaaagt  accaaatag  gtgaaatat  2880
ttacttaac  gtccgtaag  agtatatta  tattatctt  ttcaggaaa  ggttgaata  2940
tatatgcct  gtgtaatat  gaaaattga  aagtacaac  aacgcaacc  agtgtgcta  3000
aaatgagct  gattaaatc  accacctat  tttgacatg  aaatgaagc  gggtttctt  3060
tcttcactc  aattttggc  aatctcaaa  ttagatcct  agatgtgtt  ttattttta  3120
aacatcttt  ttgaaattc  atttataat  cagaatctt  ttttgaaaa  aacctaatt  3180
atatattaa  attccaaat  catggcatg  ttaaatttt  actaaattt  aaagccatt  3240
tgattattg  gttccagtt  aagttagtg  aaatctgaa  attctcctg  ggaaggcag  3300
gaaatctaa  ctgtgtctg  ccaatgaat  atggaaaat  ccatgaatt  cctggatgt  3360
ctttttacg  ggtgacaag  gttggggac  gaactccca  tacaactga  caagtttct  3420
ttctagatg  ttttttgaa  gttaacatt  atgcctgct  tttggaaag  cagaatcag  3480
agatagtct  ggaagctgt  tggaaaaga  agtggagat  aggtcagtt  tgtttttta  3540
gatggcaat  actttggta  ctgggaaag  ataaagctc  aatgaaatg  atgcattca  3600
atttagaaa  gtgaattga  gtttcaagt  ttaaagttc  ttgcaatta  acttccaaa  3660
aaagttcta  agtgtccta  gtgctaagt  cttattaca  tttattaag  tttttggaa  3720
ctttgtacc  aaattttaa  aaagggagt  tttgatagt  gtgtgtatg  gtgtgtggg  3780
tggggggat  gtaagagaa  agagagaaa  actgaaaag  aggaaagat  gttaaacat  3840
ttcccactc  ttctgaatt  attaatttg  agcacaaaa  tcaaagcat  gacatttag  3900
agaaagatg  ttggcgtag  agagttaaa  ctcaaatag  ctattaaaa  agtctacaa  3960
atagcagat  tgttttgtg  tttggaata  taaaaaact  catgtaatt  tattttaaa  4020
tttcatagc  gtacttctt  aatataaaa  atcatgcca  tatttttaa  ggcattaga  4080
tcaactaca  aaagcaggc  tgcccagta  atttaaatt  tttggcact  gccattcca  4140
aatattatg  cccaccaag  ctgagacag  gaatttggg  tgctgtagc  tattttttt  4200
gattgagaa  tgtgtagct  caaaaataa  catgaacca  tctggatgc  tcattatgt  4260
aaccaggtc  agatgtgct  taatctgtt  ttacgtatg  aggcccagt  gtcatcaga  4320
gcttgcggc  aaagaaagc  gtgtttata  ggaagaaag  aaggtgctt  gagtttacc  4380
ggcttattt  atatgctta  aacctagtt  aagaaagga  aagaaaaca  aaaacgaat  4440
aaaataact  aatttggag  ctggagtaa  cagattact  ctttaatca  aaaccctca  4500
tgtgtttct  ccggagaga  aatgtattt  ctgacaacc  ttaaagtca  aagttttac  4560
ccaggttat  gcaataaag  ataatgttt  ttaaatgct  catttgtat  tcaaagctt  4620
gactctata  gcaaattgc  tttttccaa  acaaaaaga  gtctcaggt  tgttttgtg  4680
attttctaa  agctttcat  tcccagaac  tagccttta  ctgtgaagt  ttactacag  4740
cttaatatt  tcctagtag  tctatatta  atcaaatag  tgcatagca  tatatgtta  4800
tttgtgtgt  tttagctgt  acacaactg  gtgattaaa  ggtatactt  agtagacat  4860
tataactca  ggatacctt  ttatttaat  ttttcttat  tttgtactt  atcatgaat  4920
cttttagtg  gtgcataat  gctacagtg  atagttgta  acaaagtac  ttctgggga  4980
acaacattt  tatgtagcc  ttactgttt  atataccaa  ttaaaaaaa  attgtatct  5040
attacttat  ctgggacac  attaccaaa  taataaaaa  cactttcat  atcttgaaa  5100
aa  5102



<210> 8052
<211> 543
<212> PRT
<213> Homo sapiens
<308> Q16678
<400> 8052

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
  1               5                  10                  15
Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
             20                  25                  30
Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
         35                  40                  45
Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
     50                  55                  60
Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
 65                  70                  75                  80
Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                 85                  90                  95
Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
             100                105                110
Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
         115                120                125
Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
     130                135                140
Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
 145                150                155                160
Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                 165                170                175
Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
             180                185                190
Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
         195                200                205
Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
     210                215                220
Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
 225                230                235                240
Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                 245                250                255
Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
             260                265                270
Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
         275                280                285
Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
     290                295                300
Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
 305                310                315                320
Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                 325                330                335
Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
             340                345                350
Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
         355                360                365
Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
     370                375                380
Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
 385                390                395                400
His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                 405                410                415
Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Val 
             420                425                430
Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
         435                440                445
Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
     450                455                460
Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
 465                470                475                480
Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                 485                490                495
Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
             500                505                510
Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
         515                520                525
Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
     530                535                540



<210> 8053
<211> 4964
<212> DNA
<213> Rattus norvegicus
<308> U09540
<400> 8053

gttgcagac  cctctgcga  gccagcttg  aagccgccg  cgggctggg  tttagctcc  60
ctttatcaa  tcccaaccc  tcacccatc  caaccgcaa  tccaactct  tgagaaagt  120
ctgactttg  ggagcccca  gtgcactgg  gctcagcaa  cttgagaca  ttcccccct  180
tcctccatc  taatctaag  ttaggttct  actgagcca  gagtgggtg  taaagcagc  240
ggcctcagg  gtctaggac  ccgggtcct  ggggactct  aggttgaag  cttgcagag  300
ctgggcaga  gctccagag  ttctcccag  ccccactgc  ctacaccgc  ggaaccgcg  360
ttcatcgca  catggccac  agccttagt  cagacagtc  acagcagct  agctcgctg  420
ctacccaac  gaccattct  ctgctactc  tttcggtcc  ggccatcgt  cacttaggc  480
agtggctgc  gcgccagtg  cgacggaaa  cgtggtcct  gcccccggg  ccctttcct  540
ggccattga  cggaaacgc  gcgtctgtt  gccgggcat  gcacttgta  ttcgctcgc  600
ttgcgaggc  ctatggcga  gtttttcag  tccgtctgg  cagctgtcc  gtggtggtg  660
tgaatggcg  gagtgccat  catcaggct  tggtgcagc  gggcggcgt  tttgcggac  720
ggcctccct  cgcctcttt  cgtgtggtg  ctggtggcc  cagcctggc  ttcggccac  780
actcagagc  ctggaagga  cggcgacgt  cagcctatg  cacgatgcg  gccttctcc  840
cccgccacc  gcgcagccg  ggtctcctc  agggccacg  gctgggaga  gctcgagag  900
tggtggcag  gttggtgcg  cgctgcgcc  gtggcgcct  cctcgatcc  acgcagccg  960
tcatagtgg  ggtggctaa  gtcatgagc  ctgtatgct  cggctgtcg  tacaaccac  1020
acgatgccg  gttcctgga  ctgctcagc  acaacgagg  gttcgggcg  accgtgggc  1080
cgggcagcc  ggtggacgt  atgccctgg  tgcagcttt  tcccaaccc  gtgcgcacc  1140
tcttccgcg  gttcgagca  atcaaccgc  acttcagca  cttcgtcct  gacaagttc  1200
tgaggcacc  agaaagcct  gtgcccggg  ctgctcctc  agacatgat  gacgccttc  1260
tcctctccg  cgaaaagaa  gcgactggg  accctggtg  cagtccctc  gggctggat  1320
tggaggatg  gcctgccac  attacagac  tctttggag  cagccagga  accctttcc  1380
ccgcgctgc  gtggctgct  atcctcttt  ccagatacc  ggatgtgca  gcccgcgtg  1440
aggccgagt  ggaccaggt  gtggggagg  accgcctgc  ctgcatgag  gaccaaccc  1500
acttaccat  cgtcatggc  tttctttat  aatccatgc  attcaccag  tttttgcct  1560
tcacccttc  acatgccac  actgccaac  cctttgttt  aggctacta  atccccaaa  1620
acacggtag  ttttgttaa  cagtggtct  tgaatcatg  cccagcaaa  tggtctaac  1680
cagaggact  tgatccggc  cgcttcctg  acaaggacg  cttcattaa  aaggcacta  1740
ccagcagcg  gatgatatt  tcagtgggc  aacgacggt  catcggcga  gagttgtct  1800
agacgcttc  gtttctctt  atctccatc  tcgctcatc  gtgcaattt  aaggctaac  1860
aaaacgagc  ctcaaacat  agtttcagt  acggcctga  cattaagcc  aagtcgttt  1920
aaatccatg  gtctctcag  gagtccatg  agctccttg  tagtgctgt  gagaagctg  1980
aagctgagg  agcttgcca  tgagagagg  agaggccgg  ggtaactga  atgttcaaa  2040
aaaaccatc  cattaactg  agaggaaaa  acagatttt  ttttctcca  cttcatttt  2100
gcctcagtt  tcaagaatg  gcggaaacc  agtggcctg  aggtgaggc  ggcttacca  2160
ttcatggct  ctcaccggc  agcagctgg  gatcctgaa  tattttgaa  ttgaagagt  2220
atagggtcc  aggaatttg  atactgttc  cccctcacc  ccattaaac  catgcacac  2280
aatcagcat  tgtgtacag  tatccaaca  aatatttca  taactctgc  tttttgggt  2340
gatttgaaa  ggaacttct  ttgcagaaa  tggccccat  ggaaaccac  gtaagcaga  2400
gcttaggat  tatatatat  tatatatat  ttcaagatt  aaagaagtg  tttaagtgt  2460
aaatataaa  agcagaaat  taccaagag  caaatgagc  ctcccttgt  gccctggac  2520
aggttttct  tctgcctgt  gatgtgcct  ccactctag  acggaccat  aagccgttt  2580
gctccccct  aatttatgg  tagtttaat  accacagta  gttttagag  ttagtgaat  2640
caaaggtaa  ttgtttgaa  ggcaaaagg  ttttgtaag  taaaactgt  tgtcattca  2700
ctgttcaaa  gaagcattc  agttatgag  gagaaaaag  tttgccagt  taacgtaag  2760
tttcaactt  gggatcgta  caaactgat  tgagtaata  gtcggataa  gtaaaaaat  2820
aaaaagcct  atgtcacca  atagcattc  ataaatttt  cataattat  cacaagcat  2880
atatgaata  taactattt  acaggaaag  acttgaata  tacatttct  atgtcatct  2940
gcaaaccaa  aagtataat  agttgggtg  aatttgccc  aatccagga  acgatcctg  3000
caaaatcga  ctgattaat  tcagggaag  aagtaacag  acgatcctt  cctttctta  3060
ttacagccc  tacacgaga  aaatctcaa  actaaacca  caaaaccat  ctctgatct  3120
gtaattgta  ttacaacgc  cttttcttt  ggaattgac  cctttcggt  gcgttaaga  3180
tccaaactc  tggctggct  tgattttaa  ttagtttaa  atccacctt  attattttg  3240
ttcggttga  gctggagaa  gtatggtta  tatctcaca  aaggtgaga  acctaacct  3300
tatctaagg  caaatgtca  aggcaacaa  caatcaaac  aacaaacaa  gccatgagt  3360
ctctgggtg  tcttattag  cgccctctg  caagaaact  agtaccact  gtagttggt  3420
gtttctttt  atgtgctat  actatggtt  ttgtaggtg  tttttaaat  gagtattaa  3480
gtctgcggt  ttgtgtttt  ttttaagtc  gaatctgaa  attgtcttg  gaggttgtt  3540
agcgactgc  tggggagac  gcagagacg  ctaaaattg  ctcttattt  ggatggcag  3600
ctgagcagc  gccttcctg  tagctgaga  aggagaaat  tatgtattt  gattgtgta  3660
acaatccga  acctgttaa  aagggttgg  tgagtggaa  agtagggac  gggcgcgtg  3720
ggggtttcc  atttctgtt  tcactgcaa  ttagacgga  caaaagaag  ccacggcac  3780
cagagagct  atggttggc  ctgtttcat  aggcttctt  gaattttcc  atcaaaatt  3840
caaaggaag  agtgtgtga  attcttgtg  gcagaggcc  gaagctgac  gacagagag  3900
gcatgagca  gagagaaat  tttaaatgg  ccccattca  tccaaatta  tctcttgac  3960
tgtaacatt  gaggcatga  gtttagaaa  aaaggagtt  caagggtca  gtcttacct  4020
caagtgtct  ttaagactg  ctggagacc  agccctcac  ctctctctc  cccatccac  4080
tctattttg  agttggaga  tgaattata  aaaatataa  gtaatcctt  tttaaattt  4140
tcacaacag  accccttga  tgtgaaaca  aggttgtgt  agtattttc  aggccttga  4200
ttcaactac  aaaattaac  ctgtaaaca  ttttaagtt  ttcagacat  ttaaaagca  4260
gcacctcag  aaggtcggg  cagtgattt  agcctccat  gcctcttta  tatgagaaa  4320
ttgtaagag  gaaaagtct  catgaacca  tctggactc  tcattaagc  aaccagacc  4380
agatgtttt  tgaacgtag  ggtcatgtt  gtctgatgc  ttcagcaaa  gggaaagaa  4440
ggggctact  tgtatatat  tagacccag  gaaaggaag  aggatacaa  tcaggaaag  4500
gtaacaatt  tcatattcg  aagctaata  attactggc  tagttggaa  gcctgcctt  4560
ttctgctac  gagggattt  ttttgctgg  caccatctt  atcagagta  ccacctcct  4620
tcagggcag  caaaaagta  gtttttatt  aatgtctcc  ttgcacagt  aagcttgga  4680
tatgtcaga  cgttgcttt  ttttttaaa  caaaaaata  gcctcaggt  tgttttatg  4740
attactcaa  agagttcat  ccccagaac  tagcctgta  ctgtgaaat  ttatcatgc  4800
ccttatgta  tcacaccag  gctgtgcta  attaaatag  gatcatcac  atggtatgc  4860
aattactgt  tttagcagt  acacagttg  gtgacagaa  gtgtatgtt  ccaggtgat  4920
ataacccag  aataattcc  tatttaacc  ctaaaaaaa  aaaa  4964



<210> 8054
<211> 543
<212> PRT
<213> Rattus norvegicus
<308> Q64678
<400> 8054

Met Ala Thr Ser Leu Ser Ala Asp Ser Pro Gln Gln Leu Ser Ser Leu 
  1               5                  10                  15
Ser Thr Gln Gln Thr Ile Leu Leu Leu Leu Val Ser Val Leu Ala Ile 
             20                  25                  30
Val His Leu Gly Gln Trp Leu Leu Arg Gln Trp Arg Arg Lys Pro Trp 
         35                  40                  45
Ser Ser Pro Pro Gly Pro Phe Pro Trp Pro Leu Ile Gly Asn Ala Ala 
     50                  55                  60
Ser Val Gly Arg Ala Ser His Leu Tyr Phe Ala Arg Leu Ala Arg Arg 
 65                  70                  75                  80
Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Val Val Val 
                 85                  90                  95
Leu Asn Gly Glu Ser Ala Ile His Gln Ala Leu Val Gln Gln Gly Gly 
             100                105                110
Val Phe Ala Asp Arg Pro Pro Phe Ala Ser Phe Arg Val Val Ser Gly 
         115                120                125
Gly Arg Ser Leu Ala Phe Gly His Tyr Ser Glu Arg Trp Lys Glu Arg 
     130                135                140
Arg Arg Ala Ala Tyr Gly Thr Met Arg Ala Phe Ser Thr Arg His Pro 
 145                150                155                160
Arg Ser Arg Gly Leu Leu Glu Gly His Ala Leu Gly Glu Ala Arg Glu 
                 165                170                175
Leu Val Ala Val Leu Val Arg Arg Cys Ala Gly Gly Ala Cys Leu Asp 
             180                185                190
Pro Thr Gln Pro Ile Ile Val Ala Val Ala Asn Val Met Ser Ala Val 
         195                200                205
Cys Phe Gly Cys Arg Tyr Asn His Asp Asp Ala Glu Phe Leu Glu Leu 
     210                215                220
Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
 225                230                235                240
Val Asp Val Met Pro Trp Leu Gln Leu Phe Pro Asn Pro Val Arg Thr 
                 245                250                255
Ile Phe Arg Glu Phe Glu Gln Ile Asn Arg Asn Phe Ser Asn Phe Val 
             260                265                270
Leu Asp Lys Phe Leu Arg His Arg Glu Ser Leu Val Pro Gly Ala Ala 
         275                280                285
Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
     290                295                300
Thr Gly Asp Pro Gly Asp Ser Pro Ser Gly Leu Asp Leu Glu Asp Val 
 305                310                315                320
Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                 325                330                335
Thr Ala Leu Leu Trp Leu Leu Ile Leu Phe Thr Arg Tyr Pro Asp Val 
             340                345                350
Gln Ala Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
         355                360                365
Leu Pro Cys Met Ser Asp Gln Pro Asn Leu Pro Tyr Val Met Ala Phe 
     370                375                380
Leu Tyr Glu Ser Met Arg Phe Thr Ser Phe Leu Pro Val Thr Leu Pro 
 385                390                395                400
His Ala Thr Thr Ala Asn Thr Phe Val Leu Gly Tyr Tyr Ile Pro Lys 
                 405                410                415
Asn Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Ala 
             420                425                430
Lys Trp Ser Asn Pro Glu Asp Phe Asp Pro Ala Arg Phe Leu Asp Lys 
         435                440                445
Asp Gly Phe Ile Asn Lys Ala Leu Ala Ser Ser Val Met Ile Phe Ser 
     450                455                460
Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Thr Leu Leu 
 465                470                475                480
Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asn Phe Lys Ala Asn 
                 485                490                495
Gln Asn Glu Pro Ser Asn Met Ser Phe Ser Tyr Gly Leu Ser Ile Lys 
             500                505                510
Pro Lys Ser Phe Lys Ile His Val Ser Leu Arg Glu Ser Met Lys Leu 
         515                520                525
Leu Asp Ser Ala Val Glu Lys Leu Gln Ala Glu Glu Ala Cys Gln 
     530                535                540



<210> 8055
<211> 5102
<212> DNA
<213> Homo sapiens
<308> U03688
<400> 8055

gcttctgcg  ctccagttg  gagagccgc  agggcatgg  aattgacgc  actcaccga  60
ccccagtct  aatctcaac  ctgtgagga  acctcgact  tgccaggtc  ccaagggca  120
cggggctcg  cgagcgagg  acccttctc  gtccccatc  caatccaag  gctcctggc  180
ctgacgacg  caagagact  gagtgggag  taaagcttc  agtgagggc  gcaggtgtc  240
aggccgggc  tgcgggttc  tgttgacgt  ttgccctag  caaaggtcc  agttccttc  300
cggagccgg  tgtcccgcg  cactggaaa  cgcacctcc  cgcagcatg  gcaccagcc  360
cagcccgaa  gacccttgg  cgctaaacc  gctgtccat  cagcagacc  cgctcctgc  420
actcctgtc  gtgctggcc  ctgtgcatg  gggccagcg  ctgctgagg  aacggaggc  480
gcagctccg  tccgcgccc  cgggcccgt  tgcgtggcc  ctgatcgga  acgcggcgg  540
ggtgggcca  gcggctcac  tctcgttcg  tcgcctggc  cggcgctac  gcgacgttt  600
ccagatccg  ctgggcagc  gccccatag  ggtgctgaa  ggcgagcgc  ccatccacc  660
ggccctggt  cagcagggc  cggccttcg  cgaccggcc  gccttcgcc  ccttccgtg  720
ggtgtccgg  ggccgcagc  tggctttcg  ccactactc  gagcactgg  aggtgcagc  780
gcgcgcagc  cacagcatg  tgcgcaact  cttcacgcg  cagccgcgc  gccgccaag  840
cctcgaggg  cacgtgctg  gcgaggcgc  cgagctggt  gcgctgctg  tgcgcggca  900
cgcggacgg  gccttcctc  acccgaggc  gctgaccgt  gtggccgtg  ccaacgtca  960
gagtgccgt  tgtttcggc  gccgctaca  ccacgacga  cccgagttc  gtgagctgc  1020
cagccacaa  gaagagttc  ggcgcacgg  gggcgcggg  agcctggtg  acgtgatgc  1080
ctggctgca  tacttcccc  acccggtgc  caccgtttt  cgcgaattc  agcagctca  1140
ccgcaactt  agcaacttc  tcctggaca  gttcttgag  cactgcgaa  gccttcggc  1200
cggggccgc  ccccgcgac  tgatggacg  ctttatcct  tctgcggaa  agaaggcgg  1260
cggggactc  cacggtggt  gcgcgcggc  ggatttgga  aacgtaccg  ccactatca  1320
tgacatctt  ggcgccagc  aggacaccc  gtccaccgc  ctgcagtgg  tgctcctcc  1380
cttcaccag  tatcctgat  tgcagactc  agtgcaggc  gaattggat  aggtcgtgg  1440
gagggaccg  ctgccttgt  tgggtgacc  gcccaacct  ccctatgtc  tggccttcc  1500
ttatgaagc  atgcgcttc  ccagctttg  gcctgtcac  attcctcat  ccaccactg  1560
caacacctc  gtcttgggc  accacattc  caaggacac  gtggttttt  tcaaccagt  1620
gtctgtgaa  catgaccca  tgaagtggc  taacccgga  aactttgat  cagctcgat  1680
cttggacaa  gatggcctc  tcaacaagg  cctgaccag  agagtgatg  ttttttcag  1740
gggcaaaag  cggtgcatt  gcgaagaac  ttctaagat  cagcttttt  tcttcatct  1800
catcctggc  caccagtgc  atttcaggg  caacccaaa  gagcctgcg  aaatgaatt  1860
cagttatgg  ctaaccatt  aacccaagt  atttaaagt  aatgtcact  tcagagagt  1920
catggagct  cttgatagt  ctgtccaaa  tttacaagc  aaggaaact  gccaataag  1980
agcaagagg  aagctgaaa  tttagaaat  ttcacatct  cggagatga  gagtaaaat  2040
cagtttttt  ccagttcct  ttttgtgct  cttctcaat  agcgtttaa  gtgagcata  2100
atcaactgt  catcaggtg  ggtgtgctc  atacccagc  gttcttcat  agtagtggg  2160
tatgcagga  cttctggga  atttttttg  gtcaaagac  taaagggcc  aatgaatta  2220
tatatacat  ctgcatctt  gttatttct  aaggtagca  tctttggag  taaaatgca  2280
atatagaca  atacaccca  acacttaca  caaactact  aatgaagaa  tattttggt  2340
accaggcca  ttttggtgg  aatccaaga  tggtctccc  tatgcagaa  tagacaaaa  2400
gtatattaa  caaagtttc  gagtatatt  ttgaagaga  agagacaag  aatttcagt  2460
taaagtgtg  gattgaagg  gataaggga  aagataaag  ccagaaatt  ccttttcac  2520
ttttcagga  aataactta  actctagta  ttatgggtg  atttatcct  ttgccttct  2580
gtatacttc  ttactttta  ggataaatc  taaagtcag  tgctcaaaa  gaaatcaat  2640
gttgaatta  tgagtatag  ggggttcca  gagttatca  gaattttaa  gtatgcatt  2700
ttaaattgt  aaactccaa  gtgatgttg  acctctttt  cttgccaaa  tacagaatt  2760
gaattatca  caaagaaaa  aaaaaaagc  agccaagct  taaattatg  gaccataat  2820
tactgattt  agtaagtct  ataggttaa  aaaaaaagt  accaaatag  gtgaaatat  2880
ttacttaac  gtccgtaag  agtatatta  tattatctt  ttcaggaaa  ggttgaata  2940
tatatgcct  gtgtaatat  gaaaattga  aagtacaac  aacgcaacc  agtgtgcta  3000
aaatgagct  gattaaatc  accacctat  tttgacatg  aaatgaagc  gggtttctt  3060
tcttcactc  aattttggc  aatctcaaa  ttagatcct  agatgtgtt  ttattttta  3120
aacatcttt  ttgaaattc  atttataat  cagaatctt  ttttgaaaa  aacctaatt  3180
atatattaa  attccaaat  catggcatg  ttaaatttt  actaaattt  aaagccatt  3240
tgattattg  gttccagtt  aagttagtg  aaatctgaa  attctcctg  ggaaggcag  3300
gaaatctaa  ctgtgtctg  ccaatgaat  atggaaaat  ccatgaatt  cctggatgt  3360
ctttttacg  ggtgacaag  gttggggac  gaactccca  tacaactga  caagtttct  3420
ttctagatg  ttttttgaa  gttaacatt  atgcctgct  tttggaaag  cagaatcag  3480
agatagtct  ggaagctgt  tggaaaaga  agtggagat  aggtcagtt  tgtttttta  3540
gatggcaat  actttggta  ctgggaaag  ataaagctc  aatgaaatg  atgcattca  3600
atttagaaa  gtgaattga  gtttcaagt  ttaaagttc  ttgcaatta  acttccaaa  3660
aaagttcta  agtgtccta  gtgctaagt  cttattaca  tttattaag  tttttggaa  3720
ctttgtacc  aaattttaa  aaagggagt  tttgatagt  gtgtgtatg  gtgtgtggg  3780
tggggggat  gtaagagaa  agagagaaa  actgaaaag  aggaaagat  gttaaacat  3840
ttcccactc  ttctgaatt  attaatttg  agcacaaaa  tcaaagcat  gacatttag  3900
agaaagatg  ttggcgtag  agagttaaa  ctcaaatag  ctattaaaa  agtctacaa  3960
atagcagat  tgttttgtg  tttggaata  taaaaaact  catgtaatt  tattttaaa  4020
tttcatagc  gtacttctt  aatataaaa  atcatgcca  tatttttaa  ggcattaga  4080
tcaactaca  aaagcaggc  tgcccagta  atttaaatt  tttggcact  gccattcca  4140
aatattatg  cccaccaag  ctgagacag  gaatttggg  tgctgtagc  tattttttt  4200
gattgagaa  tgtgtagct  caaaaataa  catgaacca  tctggatgc  tcattatgt  4260
aaccaggtc  agatgtgct  taatctgtt  ttacgtatg  aggcccagt  gtcatcaga  4320
gcttgcggc  aaagaaagc  gtgtttata  ggaagaaag  aaggtgctt  gagtttacc  4380
ggcttattt  atatgctta  aacctagtt  aagaaagga  aagaaaaca  aaaacgaat  4440
aaaataact  aatttggag  ctggagtaa  cagattact  ctttaatca  aaaccctca  4500
tgtgtttct  ccggagaga  aatgtattt  ctgacaacc  ttaaagtca  aagttttac  4560
ccaggttat  gcaataaag  ataatgttt  ttaaatgct  catttgtat  tcaaagctt  4620
gactctata  gcaaattgc  tttttccaa  acaaaaaga  gtctcaggt  tgttttgtg  4680
attttctaa  agctttcat  tcccagaac  tagccttta  ctgtgaagt  ttactacag  4740
cttaatatt  tcctagtag  tctatatta  atcaaatag  tgcatagca  tatatgtta  4800
tttgtgtgt  tttagctgt  acacaactg  gtgattaaa  ggtatactt  agtagacat  4860
tataactca  ggatacctt  ttatttaat  ttttcttat  tttgtactt  atcatgaat  4920
cttttagtg  gtgcataat  gctacagtg  atagttgta  acaaagtac  ttctgggga  4980
acaacattt  tatgtagcc  ttactgttt  atataccaa  ttaaaaaaa  attgtatct  5040
attacttat  ctgggacac  attaccaaa  taataaaaa  cactttcat  atcttgaaa  5100
aa  5102



<210> 8056
<211> 543
<212> PRT
<213> Homo sapiens
<308> Q16678
<400> 8056

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
  1               5                  10                  15
Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
             20                  25                  30
Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
         35                  40                  45
Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
     50                  55                  60
Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
 65                  70                  75                  80
Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                 85                  90                  95
Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
             100                105                110
Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
         115                120                125
Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
     130                135                140
Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
 145                150                155                160
Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                 165                170                175
Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
             180                185                190
Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
         195                200                205
Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
     210                215                220
Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
 225                230                235                240
Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                 245                250                255
Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
             260                265                270
Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
         275                280                285
Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
     290                295                300
Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
 305                310                315                320
Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                 325                330                335
Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
             340                345                350
Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
         355                360                365
Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
     370                375                380
Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
 385                390                395                400
His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                 405                410                415
Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Val 
             420                425                430
Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
         435                440                445
Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
     450                455                460
Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
 465                470                475                480
Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                 485                490                495
Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
             500                505                510
Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
         515                520                525
Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
     530                535                540



<210> 8057
<211> 2642
<212> DNA
<213> Rattus norvegicus
<308> U09551
<400> 8057

agtgtgctc  aaaggcgac  ggtttgtcg  agcaccata  tatggtgtg  gaagtgaag  60
cgaaccaga  gcctcatgc  gtacagaga  tcctgctgg  gatggacga  agagctaca  120
gagtgagtg  ctcattgga  ttgctgcag  gtaatgaga  tgtgccgtc  tctccagga  180
acaactcct  tgatgagca  atggagctt  atgaccttc  tgaacttca  gctgttcaa  240
gtgacccta  ccaatctgc  atataccag  tcagttcag  tgtatctca  caagaatat  300
caagaccat  ttggagcca  aatacctca  acataccgg  aaatactca  cgtgaagat  360
aggtggact  gctaacaga  ttagcaaat  ttgccacta  tccacaaag  ccactaatg  420
agtgctcat  ttataacag  tcatctcct  tacacatca  agctactag  aacagttta  480
attcctatg  acgcccacc  ccagtgtcc  ctgcaaaga  cggaccagc  ttccctcat  540
accactgga  ggaagaaac  ccagtaaga  atgaaaggg  aaacagtga  tcagagtca  600
gaattttct  catgtcctc  ctgtcagat  atgatgatc  gggctggtg  aattcctgg  660
catcaaccg  ttggcattg  tttctcaaa  gcacacgac  gtgcttcca  aaggaaagc  720
aaaaggagt  gcaagatgt  gaagacttt  ctagagccg  cacctgtga  gaggaggag  780
tccaaatgg  cactcacaa  ggctatggg  ctgatggtc  aaagttgtt  tcccatgaa  840
agagtgtgt  attcggtga  tctgtactg  agttgacat  tgatcctgg  acagtagaa  900
atggcttgc  tactgtgga  tgcaagctg  accaccctt  ctatgttaa  aataaaggc  960
ggtcatcat  ttatccaag  ttgactgtg  tacagcacg  cattccatg  tgtgagatt  1020
atattggtg  cgtatgtct  cctcctgga  accctgatg  cattaattt  gatgattca  1080
gtgtttttg  tacatttaa  agctatgac  tcacaccta  ggactcttc  gcagtctac  1140
ttttgagta  tatggctcg  cagcgccgc  catctttgt  ttgtggagg  cctggtact  1200
gtcaagagt  tgcaggatc  gaattcagt  aaagctgtg  ttcaccagg  tcatcacag  1260
tctcctcta  ttctttata  actaaagct  tcaaaagcc  cagctcagg  actgtgagt  1320
ccacttctc  taataagtg  aaaagacca  tgaatgcct  catgctttt  gccaaaaaa  1380
acagagttg  atatactca  atgtatcca  ggaaagata  cagagccat  agtgtgatc  1440
ttggtgaca  gtggaaaaa  atgaagaac  aggaaagga  gatgtatac  ttagaagca  1500
aggctttgg  tgaagaaca  aagcgttta  atcccgact  ctggaaaag  aaaagaacc  1560
attcaggct  tcaacagca  taaacctga  gcttctgtc  gtaagtctg  accttgcat  1620
agtactgac  ctgtacctg  ataaggact  actctggac  gaaaagctt  gaagacctt  1680
gtctcacca  ttgtcctac  tttgtgtga  cataaaatg  tgggagcat  gagttttgt  1740
atgatttaa  gggtgagga  gatctgctt  ctccattag  gcattaagt  agctaaaac  1800
atcaacatt  taaaccaaa  tgccttatt  tccttccaa  cttcatata  gtctatcag  1860
taatatagg  ttgaaaatt  atatcctgt  gtgctaaag  acagtagaa  gagagatgt  1920
tatacatgt  ttattttaa  ttgtacgaa  gggaattta  aaatatgta  ctgctgttt  1980
tacatcagc  ccttactgc  tattaatct  tattgtacc  acgatatca  gaatgaagt  2040
gaagctggc  tttccatga  tagccacca  atggcccag  gtctctgcc  aacacagtt  2100
cttctagtc  ggccagtgc  aagagacaa  ataacatgg  aggtggatg  tgtcattgt  2160
tcagctgag  gccacctgc  tcagatacc  tgggcgtgt  ctgagtgga  gcaccaggg  2220
gcagcacag  tccatgatt  ccagtgggg  ccaagccag  ctaaggtgc  gtcagttag  2280
attgggaca  tcattgtaa  ggtgctgtt  tcagttgaa  ccatgctcc  tgtctcctc  2340
gccacatcc  ctccgtctc  gctgtcatc  tctctgtgg  ggggcagac  ttgcactta  2400
tgcagtgca  cacttgcac  ttacccctc  ggcttctac  gtagagcaa  tccttcggc  2460
gccctgctg  tttcgctct  cgctacaat  atggcttct  atgttactt  ccaagtggt  2520
tttttggtt  ggaatcaca  ctgtaaagt  gatttcagt  cattacact  cttaaacat  2580
ttgcccctc  attttgcac  ctatattct  gtatattat  tcaaataaa  tgaaaaaag  2640
ct  2642



<210> 8058
<211> 513
<212> PRT
<213> Rattus norvegicus
<308> AAA53240
<400> 8058

Met Val Trp Glu Val Lys Thr Asn Gln Arg Pro His Ala Val Gln Arg 
  1               5                  10                  15
Leu Leu Leu Val Met Asp Glu Arg Ala Thr Gly Val Ser Asp Ser Leu 
             20                  25                  30
Glu Leu Leu Gln Cys Asn Glu Asn Val Pro Ser Ser Pro Gly Tyr Asn 
         35                  40                  45
Ser Cys Asp Glu His Met Glu Leu Asp Asp Leu Pro Glu Leu Gln Ala 
     50                  55                  60
Val Gln Ser Asp Pro Thr Gln Ser Ala Ile Tyr Gln Leu Ser Ser Asp 
 65                  70                  75                  80
Val Ser His Gln Glu Tyr Pro Arg Pro Ser Trp Ser Gln Asn Thr Ser 
                 85                  90                  95
Asp Ile Pro Glu Asn Thr His Arg Glu Asp Glu Val Asp Trp Leu Thr 
             100                105                110
Glu Leu Ala Asn Ile Ala Thr Ser Pro Gln Ser Pro Leu Met Gln Cys 
         115                120                125
Ser Phe Tyr Asn Arg Ser Ser Pro Val His Ile Ile Ala Thr Ser Asn 
     130                135                140
Ser Leu His Ser Tyr Ala Arg Pro Pro Pro Val Ser Ser Ala Lys Ser 
 145                150                155                160
Gly Pro Ala Phe Pro His Asp His Trp Lys Glu Glu Thr Pro Val Arg 
                 165                170                175
His Glu Arg Ala Asn Ser Glu Ser Glu Ser Gly Ile Phe Cys Met Ser 
             180                185                190
Ser Leu Ser Asp Asp Asp Asp Leu Gly Trp Cys Asn Ser Trp Pro Ser 
         195                200                205
Thr Val Trp His Cys Phe Leu Lys Gly Thr Arg Leu Cys Phe His Lys 
     210                215                220
Glu Ser Lys Lys Glu Trp Gln Asp Val Glu Asp Phe Ala Arg Ala Ala 
 225                230                235                240
Thr Cys Asp Glu Glu Glu Ile Gln Met Gly Thr His Lys Gly Tyr Gly 
                 245                250                255
Ser Asp Gly Leu Lys Leu Leu Ser His Glu Glu Ser Val Ser Phe Gly 
             260                265                270
Glu Ser Val Leu Lys Leu Thr Phe Asp Pro Gly Thr Val Glu Asp Gly 
         275                280                285
Leu Leu Thr Val Glu Cys Lys Leu Asp His Pro Phe Tyr Val Lys Asn 
     290                295                300
Lys Gly Trp Ser Ser Phe Tyr Pro Ser Leu Thr Val Val Gln His Gly 
 305                310                315                320
Ile Pro Cys Cys Glu Ile His Ile Gly Asp Val Cys Leu Pro Pro Gly 
                 325                330                335
His Pro Asp Ala Ile Asn Phe Asp Asp Ser Gly Val Phe Asp Thr Phe 
             340                345                350
Lys Ser Tyr Asp Phe Thr Pro Met Asp Ser Ser Ala Val Tyr Val Leu 
         355                360                365
Ser Ser Met Ala Arg Gln Arg Arg Ala Ser Leu Ser Cys Gly Gly Pro 
     370                375                380
Gly Thr Gly Gln Glu Phe Ala Gly Ser Glu Phe Ser Lys Ser Cys Gly 
 385                390                395                400
Ser Pro Gly Ser Ser Gln Leu Ser Ser Ser Ser Leu Tyr Thr Lys Ala 
                 405                410                415
Val Lys Ser His Ser Ser Gly Thr Val Ser Ala Thr Ser Pro Asn Lys 
             420                425                430
Cys Lys Arg Pro Met Asn Ala Phe Met Leu Phe Ala Lys Lys Tyr Arg 
         435                440                445
Val Glu Tyr Thr Gln Met Tyr Pro Gly Lys Asp Asn Arg Ala Ile Ser 
     450                455                460
Val Ile Leu Gly Asp Arg Trp Lys Lys Met Lys Asn Glu Glu Arg Arg 
 465                470                475                480
Met Tyr Thr Leu Glu Ala Lys Ala Leu Ala Glu Glu Gln Lys Arg Leu 
                 485                490                495
Asn Pro Asp Cys Trp Lys Arg Lys Arg Thr Asn Ser Gly Ser Gln Gln 
             500                505                510
His 
         515



<210> 8059
<211> 2704
<212> DNA
<213> Homo sapiens
<308> BC022329
<400> 8059

agacttggt  atggcgacg  gtttgtcag  gcaccataa  atggtgtgg  aagtgaaga  60
aaatcagat  cctaatgca  tacagaaac  cctgttggt  atggacaag  gagcctcag  120
aatgaatga  tcattggag  tgctgcagt  taatgagaa  ttgccatct  cacctggat  180
taactcctg  gatgaacac  tggagcttg  tgaccttcc  gaacttcag  cagttcaaa  240
tgatcctac  caatctggc  tgtaccagc  gagttcaga  gtttcacat  aagaatacc  300
aagatcatc  tggaaccaa  atacctcag  cataccaga  actacttac  gtgaaaatg  360
ggtggactg  ctaacagaa  tggcaaata  cgcgaccag  ccacaaagt  cactgatgc  420
gtgctcatt  tacaataga  catctcctg  acacatcat  gccactagc  aaagtttac  480
ttcctatgc  cgccctcca  cagtgtcct  ttcttcgaa  agtgaacca  ccttccctc  540
tcaccattg  aaggaggaa  caccagtaa  acacgaaag  gcaaatagt  agtcagaat  600
tggcatttt  tgcatgtcc  ccctgtcag  tgatgatga  ttgggatgg  gcaattcct  660
gccttcaac  gtctggcac  gttttttga  aggcacacg  ctgtgcttt  ataagggaa  720
caataagga  tggcaagat  ttgaagatt  tgctagagc  gaaggctgt  ataatgagg  780
agatcttca  atgggcatt  acaagggct  tggttctga  ggtctaaag  tgttatcac  840
tgaagaaag  gtatcattt  gcgagtctg  actgaagtt  acttttgat  ctggtacag  900
agaagatgg  ttacttacc  tagagtgta  gctggacca  cctttctat  ttaaaaata  960
aggttggtc  tcattttat  caagcttga  tgtggtaca  catggcatt  catgttgtg  1020
agttcatat  ggcgatgta  gtctacctc  tggacaccc  gatgccatt  attttgatg  1080
tccaggtgt  tttgataca  ttaaaagct  tgacttcac  cctatggat  cttctgcag  1140
ttatgtgtt  agtagtatg  ctcgccagc  tcgtgcatc  ttgtcttgt  gaggacctg  1200
tggtcaaga  tttgcaaga  ctggattca  taaaaactg  ggctcacct  gatcatcac  1260
gctctcttc  aattctttg  atgctaaag  tgtcaaaaa  cacagctca  ggactgtga  1320
tgccacttc  cctaataag  gcaaaagac  aatgaatgc  ttcatgctt  ttgccaaaa  1380
atacagagt  gaatatact  agatgtatc  agggaaaga  aacagagcc  taagtgtga  1440
ccttggtga  aggtggaag  aaatgaaga  tgaagagag  agaatgtac  cattagaag  1500
aaaggcttt  gctgaagaa  agaaacgtt  aaatcctga  tgttggaag  ggaaaagaa  1560
caattcagg  tcacaacaa  attaaacca  gatgcttat  ttcttaagt  tatatttgc  1620
tatacattg  ctcttgatg  aaagactta  gaagatcaa  gtctcacca  ttgtcctca  1680
ttcgtgtga  cataagata  tgatagcat  gagtcttga  atgatttaa  aatatgagt  1740
aggatttgc  ttctccatt  gagcattaa  ctaaaacta  caacatttt  aaccaaatt  1800
ccttatttt  cttccaaac  tcatatatg  ctatcaggt  ataataggc  tgaaaattg  1860
tatcctgtg  tgctaaagt  cagtagaaa  agaggagaa  tgtatacat  ttttatttt  1920
aattgtacg  aaggggaat  taaaaaata  gtaactgct  tttatacat  ggctcctta  1980
tgcttatta  tccgtattg  acacatgat  aaatgaagc  gaagctggg  gtcggcctt  2040
cctctagta  ccaccacat  gctcagcat  tgtgccaaa  ataggcgct  ctagtctgg  2100
cagtgccaa  aggctacca  aacatgggg  aggtggctg  tgttggtgt  ccagcctaa  2160
agccacctg  tgcagttac  atggcatgc  gagttgatg  accaggtgg  agcagccat  2220
cgttattat  tccaatgga  acctagccc  ggccaaggt  aagttagtt  atagcattg  2280
gatatagtc  ctgtaatgg  gctattaac  aacagtcaa  accattgta  tttttaact  2340
cgtgttctg  atctcctca  ccatgtatc  taaatatat  ttgtcatca  aatctttat  2400
gtgggggca  actttgcac  tactgcagt  caacacttg  actttaatt  tcctccaac  2460
gtctaaaat  agagcaaat  cattggcaa  acagctgct  ttgctctga  ctacaatca  2520
ggcttttca  gttacttac  aagtggtgt  tctggttag  aatcacagt  gtaaaattg  2580
tttcagttc  tcacacttc  tcatgatgt  gcccctaaa  tttgcacac  atattcttg  2640
atattattt  aaataaatg  gaaaaaaag  taccaaaaa  aaaaaaaaa  aaaaaaaaa  2700
aaaa  2704



<210> 8060
<211> 515
<212> PRT
<213> Homo sapiens
<308> BC022329
<400> 8060

Met Val Trp Glu Val Lys Thr Asn Gln Met Pro Asn Ala Val Gln Lys 
  1               5                  10                  15
Leu Leu Leu Val Met Asp Lys Arg Ala Ser Gly Met Asn Asp Ser Leu 
             20                  25                  30
Glu Leu Leu Gln Cys Asn Glu Asn Leu Pro Ser Ser Pro Gly Tyr Asn 
         35                  40                  45
Ser Cys Asp Glu His Met Glu Leu Asp Asp Leu Pro Glu Leu Gln Ala 
     50                  55                  60
Val Gln Ser Asp Pro Thr Gln Ser Gly Met Tyr Gln Leu Ser Ser Asp 
 65                  70                  75                  80
Val Ser His Gln Glu Tyr Pro Arg Ser Ser Trp Asn Gln Asn Thr Ser 
                 85                  90                  95
Asp Ile Pro Glu Thr Thr Tyr Arg Glu Asn Glu Val Asp Trp Leu Thr 
             100                105                110
Glu Leu Ala Asn Ile Ala Thr Ser Pro Gln Ser Pro Leu Met Leu Cys 
         115                120                125
Ser Phe Tyr Asn Arg Ser Ser Pro Val His Ile Ile Ala Thr Ser Lys 
     130                135                140
Ser Leu His Ser Tyr Ala Arg Pro Pro Pro Val Ser Ser Ser Ser Lys 
 145                150                155                160
Ser Glu Pro Ala Phe Pro His His His Trp Lys Glu Glu Thr Pro Val 
                 165                170                175
Arg His Glu Arg Ala Asn Ser Glu Ser Glu Ser Gly Ile Phe Cys Met 
             180                185                190
Ser Ser Leu Ser Asp Asp Asp Asp Leu Gly Trp Cys Asn Ser Trp Pro 
         195                200                205
Ser Thr Val Trp His Cys Phe Leu Lys Gly Thr Arg Leu Cys Phe His 
     210                215                220
Lys Gly Ser Asn Lys Glu Trp Gln Asp Val Glu Asp Phe Ala Arg Ala 
 225                230                235                240
Glu Gly Cys Asp Asn Glu Glu Asp Leu Gln Met Gly Ile His Lys Gly 
                 245                250                255
Tyr Gly Ser Asp Gly Leu Lys Leu Leu Ser His Glu Glu Ser Val Ser 
             260                265                270
Phe Gly Glu Ser Val Leu Lys Leu Thr Phe Asp Pro Gly Thr Val Glu 
         275                280                285
Asp Gly Leu Leu Thr Val Glu Cys Lys Leu Asp His Pro Phe Tyr Val 
     290                295                300
Lys Asn Lys Gly Trp Ser Ser Phe Tyr Pro Ser Leu Thr Val Val Gln 
 305                310                315                320
His Gly Ile Pro Cys Cys Glu Val His Ile Gly Asp Val Cys Leu Pro 
                 325                330                335
Pro Gly His Pro Asp Ala Ile Asn Phe Asp Asp Pro Gly Val Phe Asp 
             340                345                350
Thr Phe Lys Ser Tyr Asp Phe Thr Pro Met Asp Ser Ser Ala Val Tyr 
         355                360                365
Val Leu Ser Ser Met Ala Arg Gln Arg Arg Ala Ser Leu Ser Cys Gly 
     370                375                380
Gly Pro Gly Gly Gln Asp Phe Ala Arg Ser Gly Phe Ser Lys Asn Cys 
 385                390                395                400
Gly Ser Pro Gly Ser Ser Gln Leu Ser Ser Asn Ser Leu Tyr Ala Lys 
                 405                410                415
Ala Val Lys Asn His Ser Ser Gly Thr Val Ser Ala Thr Ser Pro Asn 
             420                425                430
Lys Cys Lys Arg Pro Met Asn Ala Phe Met Leu Phe Ala Lys Lys Tyr 
         435                440                445
Arg Val Glu Tyr Thr Gln Met Tyr Pro Gly Lys Asp Asn Arg Ala Ile 
     450                455                460
Ser Val Ile Leu Gly Asp Arg Trp Lys Lys Met Lys Asn Glu Glu Arg 
 465                470                475                480
Arg Met Tyr Thr Leu Glu Ala Lys Ala Leu Ala Glu Glu Gln Lys Arg 
                 485                490                495
Leu Asn Pro Asp Cys Trp Lys Arg Lys Arg Thr Asn Ser Gly Ser Gln 
             500                505                510
Gln His Ter 
         515



<210> 8061
<211> 2642
<212> DNA
<213> Rattus norvegicus
<308> U09551
<400> 8061

agtgtgctc  aaaggcgac  ggtttgtcg  agcaccata  tatggtgtg  gaagtgaag  60
cgaaccaga  gcctcatgc  gtacagaga  tcctgctgg  gatggacga  agagctaca  120
gagtgagtg  ctcattgga  ttgctgcag  gtaatgaga  tgtgccgtc  tctccagga  180
acaactcct  tgatgagca  atggagctt  atgaccttc  tgaacttca  gctgttcaa  240
gtgacccta  ccaatctgc  atataccag  tcagttcag  tgtatctca  caagaatat  300
caagaccat  ttggagcca  aatacctca  acataccgg  aaatactca  cgtgaagat  360
aggtggact  gctaacaga  ttagcaaat  ttgccacta  tccacaaag  ccactaatg  420
agtgctcat  ttataacag  tcatctcct  tacacatca  agctactag  aacagttta  480
attcctatg  acgcccacc  ccagtgtcc  ctgcaaaga  cggaccagc  ttccctcat  540
accactgga  ggaagaaac  ccagtaaga  atgaaaggg  aaacagtga  tcagagtca  600
gaattttct  catgtcctc  ctgtcagat  atgatgatc  gggctggtg  aattcctgg  660
catcaaccg  ttggcattg  tttctcaaa  gcacacgac  gtgcttcca  aaggaaagc  720
aaaaggagt  gcaagatgt  gaagacttt  ctagagccg  cacctgtga  gaggaggag  780
tccaaatgg  cactcacaa  ggctatggg  ctgatggtc  aaagttgtt  tcccatgaa  840
agagtgtgt  attcggtga  tctgtactg  agttgacat  tgatcctgg  acagtagaa  900
atggcttgc  tactgtgga  tgcaagctg  accaccctt  ctatgttaa  aataaaggc  960
ggtcatcat  ttatccaag  ttgactgtg  tacagcacg  cattccatg  tgtgagatt  1020
atattggtg  cgtatgtct  cctcctgga  accctgatg  cattaattt  gatgattca  1080
gtgtttttg  tacatttaa  agctatgac  tcacaccta  ggactcttc  gcagtctac  1140
ttttgagta  tatggctcg  cagcgccgc  catctttgt  ttgtggagg  cctggtact  1200
gtcaagagt  tgcaggatc  gaattcagt  aaagctgtg  ttcaccagg  tcatcacag  1260
tctcctcta  ttctttata  actaaagct  tcaaaagcc  cagctcagg  actgtgagt  1320
ccacttctc  taataagtg  aaaagacca  tgaatgcct  catgctttt  gccaaaaaa  1380
acagagttg  atatactca  atgtatcca  ggaaagata  cagagccat  agtgtgatc  1440
ttggtgaca  gtggaaaaa  atgaagaac  aggaaagga  gatgtatac  ttagaagca  1500
aggctttgg  tgaagaaca  aagcgttta  atcccgact  ctggaaaag  aaaagaacc  1560
attcaggct  tcaacagca  taaacctga  gcttctgtc  gtaagtctg  accttgcat  1620
agtactgac  ctgtacctg  ataaggact  actctggac  gaaaagctt  gaagacctt  1680
gtctcacca  ttgtcctac  tttgtgtga  cataaaatg  tgggagcat  gagttttgt  1740
atgatttaa  gggtgagga  gatctgctt  ctccattag  gcattaagt  agctaaaac  1800
atcaacatt  taaaccaaa  tgccttatt  tccttccaa  cttcatata  gtctatcag  1860
taatatagg  ttgaaaatt  atatcctgt  gtgctaaag  acagtagaa  gagagatgt  1920
tatacatgt  ttattttaa  ttgtacgaa  gggaattta  aaatatgta  ctgctgttt  1980
tacatcagc  ccttactgc  tattaatct  tattgtacc  acgatatca  gaatgaagt  2040
gaagctggc  tttccatga  tagccacca  atggcccag  gtctctgcc  aacacagtt  2100
cttctagtc  ggccagtgc  aagagacaa  ataacatgg  aggtggatg  tgtcattgt  2160
tcagctgag  gccacctgc  tcagatacc  tgggcgtgt  ctgagtgga  gcaccaggg  2220
gcagcacag  tccatgatt  ccagtgggg  ccaagccag  ctaaggtgc  gtcagttag  2280
attgggaca  tcattgtaa  ggtgctgtt  tcagttgaa  ccatgctcc  tgtctcctc  2340
gccacatcc  ctccgtctc  gctgtcatc  tctctgtgg  ggggcagac  ttgcactta  2400
tgcagtgca  cacttgcac  ttacccctc  ggcttctac  gtagagcaa  tccttcggc  2460
gccctgctg  tttcgctct  cgctacaat  atggcttct  atgttactt  ccaagtggt  2520
tttttggtt  ggaatcaca  ctgtaaagt  gatttcagt  cattacact  cttaaacat  2580
ttgcccctc  attttgcac  ctatattct  gtatattat  tcaaataaa  tgaaaaaag  2640
ct  2642



<210> 8062
<211> 513
<212> PRT
<213> Rattus norvegicus
<308> AAA53240
<400> 8062

Met Val Trp Glu Val Lys Thr Asn Gln Arg Pro His Ala Val Gln Arg 
  1               5                  10                  15
Leu Leu Leu Val Met Asp Glu Arg Ala Thr Gly Val Ser Asp Ser Leu 
             20                  25                  30
Glu Leu Leu Gln Cys Asn Glu Asn Val Pro Ser Ser Pro Gly Tyr Asn 
         35                  40                  45
Ser Cys Asp Glu His Met Glu Leu Asp Asp Leu Pro Glu Leu Gln Ala 
     50                  55                  60
Val Gln Ser Asp Pro Thr Gln Ser Ala Ile Tyr Gln Leu Ser Ser Asp 
 65                  70                  75                  80
Val Ser His Gln Glu Tyr Pro Arg Pro Ser Trp Ser Gln Asn Thr Ser 
                 85                  90                  95
Asp Ile Pro Glu Asn Thr His Arg Glu Asp Glu Val Asp Trp Leu Thr 
             100                105                110
Glu Leu Ala Asn Ile Ala Thr Ser Pro Gln Ser Pro Leu Met Gln Cys 
         115                120                125
Ser Phe Tyr Asn Arg Ser Ser Pro Val His Ile Ile Ala Thr Ser Asn 
     130                135                140
Ser Leu His Ser Tyr Ala Arg Pro Pro Pro Val Ser Ser Ala Lys Ser 
 145                150                155                160
Gly Pro Ala Phe Pro His Asp His Trp Lys Glu Glu Thr Pro Val Arg 
                 165                170                175
His Glu Arg Ala Asn Ser Glu Ser Glu Ser Gly Ile Phe Cys Met Ser 
             180                185                190
Ser Leu Ser Asp Asp Asp Asp Leu Gly Trp Cys Asn Ser Trp Pro Ser 
         195                200                205
Thr Val Trp His Cys Phe Leu Lys Gly Thr Arg Leu Cys Phe His Lys 
     210                215                220
Glu Ser Lys Lys Glu Trp Gln Asp Val Glu Asp Phe Ala Arg Ala Ala 
 225                230                235                240
Thr Cys Asp Glu Glu Glu Ile Gln Met Gly Thr His Lys Gly Tyr Gly 
                 245                250                255
Ser Asp Gly Leu Lys Leu Leu Ser His Glu Glu Ser Val Ser Phe Gly 
             260                265                270
Glu Ser Val Leu Lys Leu Thr Phe Asp Pro Gly Thr Val Glu Asp Gly 
         275                280                285
Leu Leu Thr Val Glu Cys Lys Leu Asp His Pro Phe Tyr Val Lys Asn 
     290                295                300
Lys Gly Trp Ser Ser Phe Tyr Pro Ser Leu Thr Val Val Gln His Gly 
 305                310                315                320
Ile Pro Cys Cys Glu Ile His Ile Gly Asp Val Cys Leu Pro Pro Gly 
                 325                330                335
His Pro Asp Ala Ile Asn Phe Asp Asp Ser Gly Val Phe Asp Thr Phe 
             340                345                350
Lys Ser Tyr Asp Phe Thr Pro Met Asp Ser Ser Ala Val Tyr Val Leu 
         355                360                365
Ser Ser Met Ala Arg Gln Arg Arg Ala Ser Leu Ser Cys Gly Gly Pro 
     370                375                380
Gly Thr Gly Gln Glu Phe Ala Gly Ser Glu Phe Ser Lys Ser Cys Gly 
 385                390                395                400
Ser Pro Gly Ser Ser Gln Leu Ser Ser Ser Ser Leu Tyr Thr Lys Ala 
                 405                410                415
Val Lys Ser His Ser Ser Gly Thr Val Ser Ala Thr Ser Pro Asn Lys 
             420                425                430
Cys Lys Arg Pro Met Asn Ala Phe Met Leu Phe Ala Lys Lys Tyr Arg 
         435                440                445
Val Glu Tyr Thr Gln Met Tyr Pro Gly Lys Asp Asn Arg Ala Ile Ser 
     450                455                460
Val Ile Leu Gly Asp Arg Trp Lys Lys Met Lys Asn Glu Glu Arg Arg 
 465                470                475                480
Met Tyr Thr Leu Glu Ala Lys Ala Leu Ala Glu Glu Gln Lys Arg Leu 
                 485                490                495
Asn Pro Asp Cys Trp Lys Arg Lys Arg Thr Asn Ser Gly Ser Gln Gln 
             500                505                510
His 
         515



<210> 8063
<211> 2704
<212> DNA
<213> Homo sapiens
<308> BC022329
<400> 8063

agacttggt  atggcgacg  gtttgtcag  gcaccataa  atggtgtgg  aagtgaaga  60
aaatcagat  cctaatgca  tacagaaac  cctgttggt  atggacaag  gagcctcag  120
aatgaatga  tcattggag  tgctgcagt  taatgagaa  ttgccatct  cacctggat  180
taactcctg  gatgaacac  tggagcttg  tgaccttcc  gaacttcag  cagttcaaa  240
tgatcctac  caatctggc  tgtaccagc  gagttcaga  gtttcacat  aagaatacc  300
aagatcatc  tggaaccaa  atacctcag  cataccaga  actacttac  gtgaaaatg  360
ggtggactg  ctaacagaa  tggcaaata  cgcgaccag  ccacaaagt  cactgatgc  420
gtgctcatt  tacaataga  catctcctg  acacatcat  gccactagc  aaagtttac  480
ttcctatgc  cgccctcca  cagtgtcct  ttcttcgaa  agtgaacca  ccttccctc  540
tcaccattg  aaggaggaa  caccagtaa  acacgaaag  gcaaatagt  agtcagaat  600
tggcatttt  tgcatgtcc  ccctgtcag  tgatgatga  ttgggatgg  gcaattcct  660
gccttcaac  gtctggcac  gttttttga  aggcacacg  ctgtgcttt  ataagggaa  720
caataagga  tggcaagat  ttgaagatt  tgctagagc  gaaggctgt  ataatgagg  780
agatcttca  atgggcatt  acaagggct  tggttctga  ggtctaaag  tgttatcac  840
tgaagaaag  gtatcattt  gcgagtctg  actgaagtt  acttttgat  ctggtacag  900
agaagatgg  ttacttacc  tagagtgta  gctggacca  cctttctat  ttaaaaata  960
aggttggtc  tcattttat  caagcttga  tgtggtaca  catggcatt  catgttgtg  1020
agttcatat  ggcgatgta  gtctacctc  tggacaccc  gatgccatt  attttgatg  1080
tccaggtgt  tttgataca  ttaaaagct  tgacttcac  cctatggat  cttctgcag  1140
ttatgtgtt  agtagtatg  ctcgccagc  tcgtgcatc  ttgtcttgt  gaggacctg  1200
tggtcaaga  tttgcaaga  ctggattca  taaaaactg  ggctcacct  gatcatcac  1260
gctctcttc  aattctttg  atgctaaag  tgtcaaaaa  cacagctca  ggactgtga  1320
tgccacttc  cctaataag  gcaaaagac  aatgaatgc  ttcatgctt  ttgccaaaa  1380
atacagagt  gaatatact  agatgtatc  agggaaaga  aacagagcc  taagtgtga  1440
ccttggtga  aggtggaag  aaatgaaga  tgaagagag  agaatgtac  cattagaag  1500
aaaggcttt  gctgaagaa  agaaacgtt  aaatcctga  tgttggaag  ggaaaagaa  1560
caattcagg  tcacaacaa  attaaacca  gatgcttat  ttcttaagt  tatatttgc  1620
tatacattg  ctcttgatg  aaagactta  gaagatcaa  gtctcacca  ttgtcctca  1680
ttcgtgtga  cataagata  tgatagcat  gagtcttga  atgatttaa  aatatgagt  1740
aggatttgc  ttctccatt  gagcattaa  ctaaaacta  caacatttt  aaccaaatt  1800
ccttatttt  cttccaaac  tcatatatg  ctatcaggt  ataataggc  tgaaaattg  1860
tatcctgtg  tgctaaagt  cagtagaaa  agaggagaa  tgtatacat  ttttatttt  1920
aattgtacg  aaggggaat  taaaaaata  gtaactgct  tttatacat  ggctcctta  1980
tgcttatta  tccgtattg  acacatgat  aaatgaagc  gaagctggg  gtcggcctt  2040
cctctagta  ccaccacat  gctcagcat  tgtgccaaa  ataggcgct  ctagtctgg  2100
cagtgccaa  aggctacca  aacatgggg  aggtggctg  tgttggtgt  ccagcctaa  2160
agccacctg  tgcagttac  atggcatgc  gagttgatg  accaggtgg  agcagccat  2220
cgttattat  tccaatgga  acctagccc  ggccaaggt  aagttagtt  atagcattg  2280
gatatagtc  ctgtaatgg  gctattaac  aacagtcaa  accattgta  tttttaact  2340
cgtgttctg  atctcctca  ccatgtatc  taaatatat  ttgtcatca  aatctttat  2400
gtgggggca  actttgcac  tactgcagt  caacacttg  actttaatt  tcctccaac  2460
gtctaaaat  agagcaaat  cattggcaa  acagctgct  ttgctctga  ctacaatca  2520
ggcttttca  gttacttac  aagtggtgt  tctggttag  aatcacagt  gtaaaattg  2580
tttcagttc  tcacacttc  tcatgatgt  gcccctaaa  tttgcacac  atattcttg  2640
atattattt  aaataaatg  gaaaaaaag  taccaaaaa  aaaaaaaaa  aaaaaaaaa  2700
aaaa  2704



<210> 8064
<211> 515
<212> PRT
<213> Homo sapiens
<308> BC022329
<400> 8064

Met Val Trp Glu Val Lys Thr Asn Gln Met Pro Asn Ala Val Gln Lys 
  1               5                  10                  15
Leu Leu Leu Val Met Asp Lys Arg Ala Ser Gly Met Asn Asp Ser Leu 
             20                  25                  30
Glu Leu Leu Gln Cys Asn Glu Asn Leu Pro Ser Ser Pro Gly Tyr Asn 
         35                  40                  45
Ser Cys Asp Glu His Met Glu Leu Asp Asp Leu Pro Glu Leu Gln Ala 
     50                  55                  60
Val Gln Ser Asp Pro Thr Gln Ser Gly Met Tyr Gln Leu Ser Ser Asp 
 65                  70                  75                  80
Val Ser His Gln Glu Tyr Pro Arg Ser Ser Trp Asn Gln Asn Thr Ser 
                 85                  90                  95
Asp Ile Pro Glu Thr Thr Tyr Arg Glu Asn Glu Val Asp Trp Leu Thr 
             100                105                110
Glu Leu Ala Asn Ile Ala Thr Ser Pro Gln Ser Pro Leu Met Leu Cys 
         115                120                125
Ser Phe Tyr Asn Arg Ser Ser Pro Val His Ile Ile Ala Thr Ser Lys 
     130                135                140
Ser Leu His Ser Tyr Ala Arg Pro Pro Pro Val Ser Ser Ser Ser Lys 
 145                150                155                160
Ser Glu Pro Ala Phe Pro His His His Trp Lys Glu Glu Thr Pro Val 
                 165                170                175
Arg His Glu Arg Ala Asn Ser Glu Ser Glu Ser Gly Ile Phe Cys Met 
             180                185                190
Ser Ser Leu Ser Asp Asp Asp Asp Leu Gly Trp Cys Asn Ser Trp Pro 
         195                200                205
Ser Thr Val Trp His Cys Phe Leu Lys Gly Thr Arg Leu Cys Phe His 
     210                215                220
Lys Gly Ser Asn Lys Glu Trp Gln Asp Val Glu Asp Phe Ala Arg Ala 
 225                230                235                240
Glu Gly Cys Asp Asn Glu Glu Asp Leu Gln Met Gly Ile His Lys Gly 
                 245                250                255
Tyr Gly Ser Asp Gly Leu Lys Leu Leu Ser His Glu Glu Ser Val Ser 
             260                265                270
Phe Gly Glu Ser Val Leu Lys Leu Thr Phe Asp Pro Gly Thr Val Glu 
         275                280                285
Asp Gly Leu Leu Thr Val Glu Cys Lys Leu Asp His Pro Phe Tyr Val 
     290                295                300
Lys Asn Lys Gly Trp Ser Ser Phe Tyr Pro Ser Leu Thr Val Val Gln 
 305                310                315                320
His Gly Ile Pro Cys Cys Glu Val His Ile Gly Asp Val Cys Leu Pro 
                 325                330                335
Pro Gly His Pro Asp Ala Ile Asn Phe Asp Asp Pro Gly Val Phe Asp 
             340                345                350
Thr Phe Lys Ser Tyr Asp Phe Thr Pro Met Asp Ser Ser Ala Val Tyr 
         355                360                365
Val Leu Ser Ser Met Ala Arg Gln Arg Arg Ala Ser Leu Ser Cys Gly 
     370                375                380
Gly Pro Gly Gly Gln Asp Phe Ala Arg Ser Gly Phe Ser Lys Asn Cys 
 385                390                395                400
Gly Ser Pro Gly Ser Ser Gln Leu Ser Ser Asn Ser Leu Tyr Ala Lys 
                 405                410                415
Ala Val Lys Asn His Ser Ser Gly Thr Val Ser Ala Thr Ser Pro Asn 
             420                425                430
Lys Cys Lys Arg Pro Met Asn Ala Phe Met Leu Phe Ala Lys Lys Tyr 
         435                440                445
Arg Val Glu Tyr Thr Gln Met Tyr Pro Gly Lys Asp Asn Arg Ala Ile 
     450                455                460
Ser Val Ile Leu Gly Asp Arg Trp Lys Lys Met Lys Asn Glu Glu Arg 
 465                470                475                480
Arg Met Tyr Thr Leu Glu Ala Lys Ala Leu Ala Glu Glu Gln Lys Arg 
                 485                490                495
Leu Asn Pro Asp Cys Trp Lys Arg Lys Arg Thr Asn Ser Gly Ser Gln 
             500                505                510
Gln His Ter 
         515



<210> 8065
<211> 661
<212> DNA
<213> Rattus norvegicus
<308> U09793
<400> 8065

atgactgag  ataaacttg  ggtagttgg  gctggtggc  taggcaaga  tgccttgac  60
atacagcta  ttcagaatc  ctttgtgga  gaatatgat  ctacgatag  ggactccta  120
aggaaacaa  tagtaattg  tggagaaac  tgtctcttg  atattctcg  cacagcagg  180
caagaggag  acagtgcaa  gagggacca  tacatgaga  ctggggagg  ctttctttg  240
gtatttgcc  taaataata  taaatcatt  gaagatatt  accattata  agaacaaat  300
aaaagagta  aggactctg  agatgtgcc  atggtccta  tagggaata  gtgtgactt  360
ccttctaga  cagtagaca  gaaacaggc  caggagtta  caaggagtt  tgggattcc  420
ttcattgag  cctcagcga  gacaagaca  ggtgttgac  atgccttct  tacattagt  480
cgagaaatt  gaaaacata  agaaaagat  agcaaagat  ggaaaaaga  gaagaagaa  540
tcaaggaca  ggtgtatag  catgtgaat  gtttgtact  tttcttaag  cacacttaa  600
taaagtgtg  tttttgtac  ttacactaa  ttattagca  ttgttttag  attacctaa  660
c  661



<210> 8066
<211> 188
<212> PRT
<213> Rattus norvegicus
<308> P46203
<400> 8066

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
  1               5                  10                  15
Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
             20                  25                  30
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
         35                  40                  45
Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
     50                  55                  60
Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
 65                  70                  75                  80
Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                 85                  90                  95
Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
             100                105                110
Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
         115                120                125
Gln Ala Gln Glu Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
     130                135                140
Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
 145                150                155                160
Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                 165                170                175
Lys Lys Lys Lys Ser Arg Thr Arg Cys Ile Val Met 
             180                185



<210> 8067
<211> 1362
<212> DNA
<213> Homo sapiens
<308> NM_004985
<400> 8067

ggccgcggc  gcggaggca  cagcggcgg  ggcagtggc  gcggcgaag  tggcggcgg  60
tcggccagt  ctcccggcc  ccgccattt  ggactggga  cgagcgcgg  gcaggcact  120
aaggcggcg  cggggccag  ggctcagcg  ctcccaggt  cgggagaga  gcctgctga  180
aatgactga  tataaactt  tggtagttg  agctggtgg  gtaggcaag  gtgccttga  240
gatacagct  attcagaat  attttgtgg  cgaatatga  ccaacaata  aggattcct  300
caggaagca  gtagtaatt  atggagaaa  ctgtctctt  gatattctc  acacagcag  360
tcaagagga  tacagtgca  tgagggacc  gtacatgag  actggggag  gctttcttt  420
tgtatttgc  ataaataat  ctaaatcat  tgaagatat  caccattat  gagaacaaa  480
taaaagagt  aaggactct  aagatgtac  tatggtcct  gtaggaaat  aatgtgatt  540
gccttctag  acagtagac  caaaacagg  tcaggactt  gcaagaagt  atggaattc  600
ttttattga  acatcagca  agacaagac  gggtgttga  gatgccttc  atacattag  660
tcgagaaat  cgaaaacat  aagaaaaga  gagcaaaga  ggtaaaaag  agaaaaaga  720
gtcaaagac  aagtgtgta  ttatgtaaa  acaatttgt  cttttttct  aaggcatac  780
agtacaagt  gtaattttt  tacattaca  taaattatt  gcatttgtt  tagcattac  840
taatttttt  cctgctcca  gcagactgt  agcttttac  ttaaatgct  attttaaaa  900
gacagtgga  gtttttttt  cctcgaagt  ccagtattc  cagagtttt  gtttttgaa  960
tagcaatgc  tgtgaaaaa  aaactgaat  cctaagatt  ctgtcttgg  gtttttggt  1020
catgcagtt  attacttct  atttttctt  ccaagtgtg  atgttggtg  gaaacaaat  1080
aatgaagct  ttgaatcat  cctattctg  gttttatct  gtcacataa  tggattaat  1140
actaatttc  gttgagacc  tctaattgg  ttttactga  acattgagg  aacacaaat  1200
tatgggctt  ctgatgatg  ttcttctag  catcatgtc  tatagtttg  catccctga  1260
gaatgtaaa  ttacactgt  cacaaaggt  ttgtctcct  tccactgct  ttagtcatg  1320
tcactctcc  caaaatatt  tattttttc  ataaaaaaa  aa  1362



<210> 8068
<211> 188
<212> PRT
<213> Homo sapiens
<308> P01118
<400> 8068

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
  1               5                  10                  15
Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
             20                  25                  30
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
         35                  40                  45
Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
     50                  55                  60
Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
 65                  70                  75                  80
Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                 85                  90                  95
Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
             100                105                110
Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
         115                120                125
Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
     130                135                140
Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
 145                150                155                160
Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                 165                170                175
Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
             180                185



<210> 8069
<211> 4113
<212> DNA
<213> Rattus norvegicus
<308> U10354
<400> 8069

cgggactct  caggccggc  caggcaccg  actgtaggt  tatttggag  gatttggag  60
ctggagacc  caggaagca  gcaggcggg  gcaggcaag  ggcggagcc  cgggcccgg  120
caaggtggc  gtcagaggg  ctgcgggga  gcagtagct  gacccaagg  gaccaggga  180
cttcagacg  tagcacgcc  ctcaaacaa  ttaacttga  atcgcaagc  gggcgggct  240
gtacgacat  ctgacttca  catccagct  ttcctgggc  gacagaggg  caacaggtg  300
tcctgtgga  gaagccagg  caaggactc  agaaaacat  tcgggcagc  tctacatga  360
gtcacttct  aggactcga  gaccagcca  cctacacct  tactacaga  aaggcagaa  420
tggagaccc  aaggccatc  ctcctgctc  gtcactaac  actctgtaa  catgtctcc  480
caccagaag  tgtgaaccg  accagggcc  tggagttct  gggctccca  tccactgac  540
cctttacct  tcccctgaa  agaaggcaa  gctatggca  cgtacagct  ctgtttggc  600
ctattggct  ttgcctggc  ctcctctgc  tatgggcct  accagcgag  ccaaaagaa  660
ggggacatt  tcctaggag  tctctttcc  atccatttt  gagtagcag  caaagatca  720
gatctgaag  caagaccag  gtctgtgga  tgcattagg  ataacttcc  tggattccg  780
tggttacaa  ccatgatat  cgccataga  gagataaac  gcagcccct  ccttcttcc  840
aacatgaca  tgggatata  gatatttga  acctgtaac  ccgtctcca  ggcgctgga  900
gccaccttg  gttttgttg  ccagaacaa  atcgattct  tgaacctgg  cgagttctg  960
aactgctct  agcacatcc  ttcgaccat  gccgtggtg  gagccaccg  ctccggtgt  1020
tccacggcg  tagccaacc  gctgggact  ttctacatc  cccaggtga  ctacgcctc  1080
tccagcagg  tcctcagca  taagaacca  tacaaatcc  tcctccgca  cattcccaa  1140
gacgaacac  aggcaaccg  gatggccga  atcatcgag  acttccgct  gaactgggt  1200
ggcacaatt  cagctgatg  cgactatgg  agacctggc  ttgagaagt  ccgagagga  1260
gccgaagag  gggatatct  cattgattt  agcgagctc  tctcccagt  ctctgacga  1320
gaagagatc  agcaggtgg  cgaagtgat  caaaactct  cggccaagg  cattgtcgt  1380
ttctccagc  gcccggacc  agaacctct  atcaaggag  ttgtgcggc  taacatcac  1440
ggcaggatc  ggctggcta  cgaggcctg  gccagttcc  cgctgattg  tatgcctga  1500
tatttccat  tagtcgggg  caccattgg  ttcggtctg  aggctgggc  gattccagg  1560
ttcagagaa  tcctacaga  agttcatcc  aggaagtct  tccacaatg  ttttgccaa  1620
gagttttgg  aagaaactt  taattgcca  ctccaagaa  gcgcaaaag  acctttacc  1680
gtggacacc  tcgtgagaa  tcacgaaga  ggtggcaac  ggttactca  tagctctac  1740
gccttccga  ccctctgca  aggggatga  aacatcaac  gtgtggaga  cccttacat  1800
gattacgaa  atttacgga  atcctacaa  gtgtactta  ccgtctact  cattgcgca  1860
gccctacaa  atatataca  ctgcttacc  ggaagaggg  ttttcacca  cgggtcctg  1920
gcagacatc  agaaggttg  ggcctggca  gtcttgaag  acctacggc  cctgaactt  1980
accaacaac  tgggggagc  ggtgacctt  gatgagtgt  gtgatctgg  ggggaacta  2040
tctatcatc  actggcacc  ctccccaga  gacggctcc  ttgtgttca  ggaagttgg  2100
tactacaat  tgtatgcca  gaagggaga  agactcttc  tcaatgagg  gaagatctt  2160
tggagtggg  tctccagag  ggtgccttt  tccaattgc  gccgggact  tcaggcagg  2220
accaggaag  ggatcatcg  gggagagcc  acctgctgc  ttgagtgtg  ggagtgtcc  2280
gatggagag  acagtggag  gacagatgc  agtgcctgt  acaagtgcc  ggatgactt  2340
tggtccaat  agaaccaca  ttcttgcat  gccaaggag  ttgagtttc  ggcgtggac  2400
gagcccttt  gaatcgctc  cactctctt  gcggtgctg  gcattttcc  gaccgcctt  2460
gtgctgggt  tcttcatca  gttccgaaa  acacctatc  tcaaggcca  caaccgaga  2520
ctgtcctac  tcctgctct  ctccctact  tgctgcttc  ccagctcct  gttcttcat  2580
ggggagccc  aggactgga  gtgccgcct  cgacagcct  ctttcggca  cagctttgt  2640
ctctgtatc  cgtgcatct  ggtgaagac  aatcgcgtc  tcctggtat  tgaagccaa  2700
atacccacc  gcttccacc  gaagtggtg  gggctcaac  tgcagttcc  gctggtttt  2760
ctctgcacc  tcatgcaga  cctcatctg  atcatctgg  tctacacgg  gcccccctc  2820
agctaccgc  accatgagc  ggaagacga  atcatcttc  tcacgtgcc  tgagggctc  2880
ctcatggca  ttggctccc  gatcggcta  acctgcctg  tggctgcca  ctgcttctt  2940
tttgccttc  agtccagga  gttaccaga  aacttcaac  aagccaagt  cattacctt  3000
agcatgctc  tcttcttca  cgtctggat  tccttcatt  cagcctatg  cagcaccta  3060
ggcaagttt  tctctgccg  agaggtgat  gccattttg  cagccagct  tggcttact  3120
gcctgcatc  tcttcaaca  ggtctacat  atcctcttc  agccttccc  gaacaccat  3180
gaggaagtc  gctccagca  cgcagcaca  gctttcaaa  tagcagccc  cgccactct  3240
cgccgtccc  acatctccc  gaagcggtc  agcagcctt  gaggctcca  cggctccat  3300
ccctcctcc  ccatcagca  caaaagcaa  agcgaagac  ggttcccgc  gccagagag  3360
cagaagcaa  agcaaccgc  gtccctgac  cagcaagaa  agcagcagc  gcccctgac  3420
ctccaccca  agcaacagc  gcagccaca  cagccgaga  gcaaacaga  ggtcatctt  3480
ggcagtggt  cggtcacct  ctctctgag  tttgacgag  ctcagaaga  tgccatggc  3540
cacaggaac  ccatgcgtc  gaactccct  gaggcccag  ggagcaacg  caccttggg  3600
agacaccag  ccctgcttc  cctacagtg  gcagatgcg  actcagaaa  gaccattca  3660
gaaacgggc  tgcaagggc  catggtggg  gaccaccag  cagaaatgg  aagctcaga  3720
gaaatgtcc  cagcgctgg  catgtccac  tctcggagc  tcgtcatta  tggtggagg  3780
agctctgtg  cggaaaacg  attacactc  taatggagg  aaaggctat  cagttgaga  3840
gtttttctt  gagccctga  caaaaggat  ggtccttcc  ttcttccca  gaagccagg  3900
agagtaggt  cgtcaaagc  tgtactcag  tgcactgct  tgaatgaca  tgaactgac  3960
ggtgtgctc  ttagagtta  aagaagagc  atgttttgg  gtcgttttc  agagctcag  4020
atcacacct  ggtttgctg  agtcttttc  tctgctcta  ccaccatca  ttcagacga  4080
agcaaggct  taagctacc  atctgcttc  ctc  4113



<210> 8070
<211> 1079
<212> PRT
<213> Rattus norvegicus
<308> P48442
<400> 8070

Met Ala Ser Tyr Ser Cys Cys Leu Ala Leu Leu Ala Leu Ala Trp His 
  1               5                  10                  15
Ser Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
             20                  25                  30
Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp 
         35                  40                  45
Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn 
     50                  55                  60
Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu 
 65                  70                  75                  80
Ile Asn Ser Ser Pro Ser Leu Leu Pro Asn Met Thr Leu Gly Tyr Arg 
                 85                  90                  95
Ile Phe Asp Thr Cys Asn Thr Val Ser Lys Ala Leu Glu Ala Thr Leu 
             100                105                110
Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe 
         115                120                125
Cys Asn Cys Ser Glu His Ile Pro Ser Thr Ile Ala Val Val Gly Ala 
     130                135                140
Thr Gly Ser Gly Val Ser Thr Ala Val Ala Asn Leu Leu Gly Leu Phe 
 145                150                155                160
Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn 
                 165                170                175
Lys Asn Gln Tyr Lys Ser Phe Leu Arg Thr Ile Pro Asn Asp Glu His 
             180                185                190
Gln Ala Thr Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp 
         195                200                205
Val Gly Thr Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu 
     210                215                220
Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser 
 225                230                235                240
Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln Gln Val Val 
                 245                250                255
Glu Val Ile Gln Asn Ser Thr Ala Lys Val Ile Val Val Phe Ser Ser 
             260                265                270
Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile 
         275                280                285
Thr Gly Arg Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu 
     290                295                300
Ile Ala Met Pro Glu Tyr Phe His Val Val Gly Gly Thr Ile Gly Phe 
 305                310                315                320
Gly Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Gln Lys 
                 325                330                335
Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp 
             340                345                350
Glu Glu Thr Phe Asn Cys His Leu Gln Glu Gly Ala Lys Gly Pro Leu 
         355                360                365
Pro Val Asp Thr Phe Val Arg Ser His Glu Glu Gly Gly Asn Arg Leu 
     370                375                380
Leu Asn Ser Ser Thr Ala Phe Arg Pro Leu Cys Thr Gly Asp Glu Asn 
 385                390                395                400
Ile Asn Ser Val Glu Thr Pro Tyr Met Asp Tyr Glu His Leu Arg Ile 
                 405                410                415
Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln 
             420                425                430
Asp Ile Tyr Thr Cys Leu Pro Gly Arg Gly Leu Phe Thr Asn Gly Ser 
         435                440                445
Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu 
     450                455                460
Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu Gln Val Thr Phe Asp 
 465                470                475                480
Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu 
                 485                490                495
Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn 
             500                505                510
Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys Ile 
         515                520                525
Leu Trp Ser Gly Phe Ser Arg Glu Val Pro Phe Ser Asn Cys Ser Arg 
     530                535                540
Asp Cys Gln Ala Gly Thr Arg Lys Gly Ile Ile Glu Gly Glu Pro Thr 
 545                550                555                560
Cys Cys Phe Glu Cys Val Glu Cys Pro Asp Gly Glu Tyr Ser Gly Glu 
                 565                570                575
Thr Asp Ala Ser Ala Cys Asp Lys Cys Pro Asp Asp Phe Trp Ser Asn 
             580                585                590
Glu Asn His Thr Ser Cys Ile Ala Lys Glu Ile Glu Phe Leu Ala Trp 
         595                600                605
Thr Glu Pro Phe Gly Ile Ala Leu Thr Leu Phe Ala Val Leu Gly Ile 
     610                615                620
Phe Leu Thr Ala Phe Val Leu Gly Val Phe Ile Lys Phe Arg Asn Thr 
 625                630                635                640
Pro Ile Val Lys Ala Thr Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe 
                 645                650                655
Ser Leu Leu Cys Cys Phe Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro 
             660                665                670
Gln Asp Trp Thr Cys Arg Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe 
         675                680                685
Val Leu Cys Ile Ser Cys Ile Leu Val Lys Thr Asn Arg Val Leu Leu 
     690                695                700
Val Phe Glu Ala Lys Ile Pro Thr Ser Phe His Arg Lys Trp Trp Gly 
 705                710                715                720
Leu Asn Leu Gln Phe Leu Leu Val Phe Leu Cys Thr Phe Met Gln Ile 
                 725                730                735
Leu Ile Cys Ile Ile Trp Leu Tyr Thr Ala Pro Pro Ser Ser Tyr Arg 
             740                745                750
Asn His Glu Leu Glu Asp Glu Ile Ile Phe Ile Thr Cys His Glu Gly 
         755                760                765
Ser Leu Met Ala Leu Gly Ser Leu Ile Gly Tyr Thr Cys Leu Leu Ala 
     770                775                780
Ala Ile Cys Phe Phe Phe Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn 
 785                790                795                800
Phe Asn Glu Ala Lys Phe Ile Thr Phe Ser Met Leu Ile Phe Phe Ile 
                 805                810                815
Val Trp Ile Ser Phe Ile Pro Ala Tyr Ala Ser Thr Tyr Gly Lys Phe 
             820                825                830
Val Ser Ala Val Glu Val Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu 
         835                840                845
Leu Ala Cys Ile Phe Phe Asn Lys Val Tyr Ile Ile Leu Phe Lys Pro 
     850                855                860
Ser Arg Asn Thr Ile Glu Glu Val Arg Ser Ser Thr Ala Ala His Ala 
 865                870                875                880
Phe Lys Val Ala Ala Arg Ala Thr Leu Arg Arg Pro Asn Ile Ser Arg 
                 885                890                895
Lys Arg Ser Ser Ser Leu Gly Gly Ser Thr Gly Ser Ile Pro Ser Ser 
             900                905                910
Ser Ile Ser Ser Lys Ser Asn Ser Glu Asp Arg Phe Pro Gln Pro Glu 
         915                920                925
Arg Gln Lys Gln Gln Gln Pro Leu Ser Leu Thr Gln Gln Glu Gln Gln 
     930                935                940
Gln Gln Pro Leu Thr Leu His Pro Gln Gln Gln Gln Gln Pro Gln Gln 
 945                950                955                960
Pro Arg Cys Lys Gln Lys Val Ile Phe Gly Ser Gly Thr Val Thr Phe 
                 965                970                975
Ser Leu Ser Phe Asp Glu Pro Gln Lys Asn Ala Met Ala His Arg Asn 
             980                985                990
Ser Met Arg Gln Asn Ser Leu Glu Ala Gln Arg Ser Asn Asp Thr Leu 
         995                1000                1005
Gly Arg His Gln Ala Leu Leu Pro Leu Gln Cys Ala Asp Ala Asp Ser 
     1010                1015                1020
Glu Met Thr Ile Gln Glu Thr Gly Leu Gln Gly Pro Met Val Gly Asp 
 1025                1030                1035                1040
His Gln Pro Glu Met Glu Ser Ser Asp Glu Met Ser Pro Ala Leu Val 
                 1045                1050                1055
Met Ser Thr Ser Arg Ser Phe Val Ile Ser Gly Gly Gly Ser Ser Val 
             1060                1065                1070
Thr Glu Asn Val Leu His Ser 
         1075



<210> 8071
<211> 5009
<212> DNA
<213> Homo sapiens
<308> U20760
<400> 8071

ggggctgct  tggccggac  cgaaggcgg  cgccgggag  gcagcgagc  agacgcgcc  60
ctccaagac  gtgaccttg  catagggag  ggggctgcg  gcagtcctg  gatcagacc  120
gagctcatc  tcgtggaga  ccacggccg  ggggccgga  ctgcctctg  gcgagggag  180
cctggccgc  gcgcagaag  catcacagg  ggcctctgc  tgatgtggc  tccaaagac  240
caaggacca  ccacattac  agtctggat  gaggaaggc  gaaatggag  ttcaaacac  300
acgtcttct  ttattttat  aatcaatct  tagacatgt  tccccactg  agggagtga  360
ctgctccaa  ggagaaact  ctgggagcc  ccaaactcc  agctgtctc  tcccttgcc  420
tggagagac  gcagaacca  ggcatttta  agctgctgc  gggtcctct  ggcactcac  480
tggcacacc  ctgcctacg  gccagacca  cgagcccaa  agaaggggg  cattatcct  540
ggggggctc  ttcctattc  ttttggagt  gcagctaaa  atcaagatc  caaatcaag  600
ccggagtct  tggaatgta  caggtataa  ttccgtggg  ttcgctggt  acaggctat  660
atatttgcc  tagaggaga  aaacagcag  ccagccctt  ttcccaact  gacgctggg  720
tacaggata  ttgacactt  caacaccgt  tctaaggcc  tggaagcca  cctgagttt  780
gttgctcaa  acaaaattg  ttctttgaa  cttgatgag  tctgcaact  ctcagagca  840
attccctct  cgattgctg  ggtgggagc  actggctca  gcgtctcca  ggcagtggc  900
aatctgctg  ggctcttct  cattcccca  gtcagttat  cctcctcca  cagactcct  960
agcaacaag  atcaattca  gtctttcct  cgaaccatc  ccaatgatg  gcaccaggc  1020
actgccatg  cagacatca  cgagtattt  cgctggaac  gggtgggca  aattgcagc  1080
gatgacgac  atgggcggc  ggggattga  aaattccga  aggaagctg  ggaaaggga  1140
atctgcatc  acttcagtg  actcatctc  cagtactct  atgaggaag  gatccagca  1200
gtggtagag  tgattcaaa  ttccacggc  aaagtcatc  tggttttct  cagtggccc  1260
gatcttgag  ccctcatca  ggagattgt  cggcgcaat  tcacgggca  gatctggct  1320
gccagcgag  cctgggcca  ctcctccct  atcgccatg  ctcagtact  ccacgtggt  1380
ggcggcacc  ttggattcg  tctgaaggc  gggcagatc  caggcttcc  ggaattcct  1440
aagaaggtc  atcccagga  gtctgtcca  aatggtttt  ccaaggagt  ttgggaaga  1500
acatttaac  gccacctcc  agaaggtgc  aaaggacct  tacctgtgg  cacctttct  1560
agaggtcac  aagaaagtg  cgacaggtt  agcaacagc  cgacagcct  ccgacccct  1620
tgtacaggg  atgagaaca  cagcagtgt  gagacccct  acatagatt  cacgcattt  1680
cggatatcc  acaatgtgt  cttagcagt  tactccatt  cccacgcct  gcaagatat  1740
tatacctgc  tacctggga  agggctctt  accaatggc  cctgtgcag  catcaagaa  1800
gttgaggcg  ggcaggtcc  gaagcacct  cggcatcta  actttacaa  caatatggg  1860
gagcaggtg  cctttgatg  gtgtggtga  ctggtgggg  actattcca  catcaactg  1920
cacctctcc  cagaggatg  ctccatcgt  tttaaggaa  tcgggtatt  caacgtcta  1980
gccaagaag  gagaaagac  cttcatcaa  gaggagaaa  tcctgtgga  tgggttctc  2040
agggagcca  tcacctttg  gctgtctgt  ctccaggtg  ccttctcca  ctgcagccg  2100
gactgcctg  cagggacca  gaaagggat  attgagggg  agcccacct  ctgctttga  2160
tgtgtggag  gtcctgatg  ggagtatag  gatgagaca  atgccagtg  ctgtaacaa  2220
tgcccagat  acttctggt  caatgagaa  cacacctcc  gcattgcca  ggagatcga  2280
tttctgtcg  ggacggagc  ctttgggat  gcactcacc  tctttgccg  gctgggcat  2340
ttcctgaca  cctttgtgc  gggtgtgtt  atcaagttc  gcaacacac  cattgtcaa  2400
gccaccaac  gagagctct  ctacctcct  ctcttctcc  tgctctgct  cttctccag  2460
tccctgttc  tcatcgggg  gccccagga  tggacgtgc  gcctgcgcc  gccggcctt  2520
ggcatcagc  tcgtgctct  catctcatg  atcctggtg  aaaccaacc  tgtcctcct  2580
gtgtttgag  ccaagatcc  caccagctt  caccgcaag  ggtgggggc  caacctgca  2640
ttcctgctg  ttttcctct  caccttcat  cagattgtc  tctgtgtga  ctggctcta  2700
accgcgccc  cctcaagct  ccgcaacca  gagctggag  atgagatca  cttcatcac  2760
tgccacgag  gctccctca  ggccctggg  ttcctgatc  gctacacct  cctgctggc  2820
gccatctgc  tcttctttg  cttcaagtc  cggaagctg  cggagaact  caatgaagc  2880
aagttcatc  ccttcagca  gctcatctt  ttcatcgtc  ggatctcct  cattccagc  2940
tatgccagc  cctatggca  gtttgtctc  gccgtagag  tgattgcca  cctggcagc  3000
agctttggc  tgctggcgt  catcttctt  aacaagatc  acatcattc  cttcaagcc  3060
tcccgcaac  ccatcgagg  ggtgcgttg  agcaccgca  ctcacgctt  caaggtggc  3120
gcccgggcc  cgctgcgcc  cagcaacgt  tcccgcaag  ggtccagca  ccttggagg  3180
tccacggga  ccaccccct  ctcctccat  agcagcaag  gcaacagcg  agacccatt  3240
ccacggccc  agaggcaga  gcagcagca  ccgctggcc  taacccagc  agagcagca  3300
cagcagccc  tgaccctcc  acagcagca  cgatctcag  agcagccca  atgcaagca  3360
aaggtcatc  ttggcagcg  cacggtcac  ttctcactg  gctttgatg  gcctcagaa  3420
aacgccatg  cccacagga  ttctacgca  cagaactcc  tggaggccc  gaaaagcag  3480
gatacgctg  cccgacacc  gccattact  ccgctgcag  gcggggaaa  ggacttaga  3540
ctgaccgtc  aggaaacag  tctgcaagg  cctgtgggt  gagaccagc  gccagaggt  3600
gaggaccct  aagagttgt  cccagcact  gtagtgtcc  gttcacaga  ctttgtcat  3660
agtggtgga  gcagcactg  tacagaaaa  gtagtgaat  cataaaatg  aaggagaag  3720
ctgggctag  gagaatgca  agaggtttc  tggggtccc  gggatgagg  atcgcccca  3780
actcctttc  tctgaggaa  aagggataa  agacacatc  aatgccccg  atttagtca  3840
accatctta  atgacagtg  attgaccca  gttcccttt  aaattaaaa  aaagaagag  3900
cttgtgttt  tgtggttgc  tttgtcaaa  cattgagat  tccacggtc  gatttgctg  3960
tcacccaca  ctaatgtct  ttcctctgt  ctatcccac  caacagctc  gagatgaaa  4020
tatggcttt  aactaccct  cagagtgtg  agactgatg  gacatcaaa  ttgccacca  4080
tagagctga  agtctgaaa  acagaatgt  accagtcct  cccaatgcc  tgacaacag  4140
ctgaatttt  aatgttcac  acataagga  aatgtatct  ctcctattt  tgaaaacca  4200
atgatattt  gtctcctac  tgctgctgc  attatgtaa  atccagaag  tttgcaccc  4260
tcctatacc  tatgtctgg  tctgtccag  acatgatac  gatgccatg  ttagattcc  4320
ggatcacaa  aatcacctc  aattgttag  aagggactg  ataaaccaa  gagctgtat  4380
tgtaattaa  attcctata  gtagcttta  ccttaggaa  atgcttctg  tgtaatagt  4440
catggacaa  ataaactga  aaatgtcag  ctggtttat  taaggcagt  ttattgagc  4500
ctatttccc  accccacta  cctcactcc  ataagctaa  ccttatgtg  gccccttca  4560
ggactcaag  gtccagaag  ccctcccat  tctacccca  agaattcct  aagccagat  4620
caccctatc  ctgtacaga  taagttctc  attattggc  tgctaatag  tgctagggt  4680
ggaaagcgt  gttccaaga  agatccacc  tcaaatgtc  gagctatgt  ccctccagc  4740
gtggtatta  tactgccgg  cacccaggc  ctggagcca  agagacaga  cggggttca  4800
gccatggct  cgtcatttg  aagctgagt  actgtaggc  gggaacctt  acctctcta  4860
gccacagct  cttcatctt  aaaataagg  taataatca  tccttcccc  cagagctct  4920
atgtggatt  aacgagata  tgtatataa  gtactttag  ctggtacct  gcacacaat  4980
agcattcaa  aaatattag  taatattat  5009



<210> 8072
<211> 1078
<212> PRT
<213> Homo sapiens
<308> P41180
<400> 8072

Met Ala Phe Tyr Ser Cys Cys Trp Val Leu Leu Ala Leu Thr Trp His 
  1               5                  10                  15
Thr Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
             20                  25                  30
Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp 
         35                  40                  45
Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn 
     50                  55                  60
Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu 
 65                  70                  75                  80
Ile Asn Ser Ser Pro Ala Leu Leu Pro Asn Leu Thr Leu Gly Tyr Arg 
                 85                  90                  95
Ile Phe Asp Thr Cys Asn Thr Val Ser Lys Ala Leu Glu Ala Thr Leu 
             100                105                110
Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe 
         115                120                125
Cys Asn Cys Ser Glu His Ile Pro Ser Thr Ile Ala Val Val Gly Ala 
     130                135                140
Thr Gly Ser Gly Val Ser Thr Ala Val Ala Asn Leu Leu Gly Leu Phe 
 145                150                155                160
Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn 
                 165                170                175
Lys Asn Gln Phe Lys Ser Phe Leu Arg Thr Ile Pro Asn Asp Glu His 
             180                185                190
Gln Ala Thr Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp 
         195                200                205
Val Gly Thr Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu 
     210                215                220
Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser 
 225                230                235                240
Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln His Val Val 
                 245                250                255
Glu Val Ile Gln Asn Ser Thr Ala Lys Val Ile Val Val Phe Ser Ser 
             260                265                270
Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile 
         275                280                285
Thr Gly Lys Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu 
     290                295                300
Ile Ala Met Pro Gln Tyr Phe His Val Val Gly Gly Thr Ile Gly Phe 
 305                310                315                320
Ala Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Lys Lys 
                 325                330                335
Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp 
             340                345                350
Glu Glu Thr Phe Asn Cys His Leu Gln Glu Gly Ala Lys Gly Pro Leu 
         355                360                365
Pro Val Asp Thr Phe Leu Arg Gly His Glu Glu Ser Gly Asp Arg Phe 
     370                375                380
Ser Asn Ser Ser Thr Ala Phe Arg Pro Leu Cys Thr Gly Asp Glu Asn 
 385                390                395                400
Ile Ser Ser Val Glu Thr Pro Tyr Ile Asp Tyr Thr His Leu Arg Ile 
                 405                410                415
Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln 
             420                425                430
Asp Ile Tyr Thr Cys Leu Pro Gly Arg Gly Leu Phe Thr Asn Gly Ser 
         435                440                445
Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu 
     450                455                460
Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu Gln Val Thr Phe Asp 
 465                470                475                480
Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu 
                 485                490                495
Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn 
             500                505                510
Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys Ile 
         515                520                525
Leu Trp Ser Gly Phe Ser Arg Glu Val Pro Phe Ser Asn Cys Ser Arg 
     530                535                540
Asp Cys Leu Ala Gly Thr Arg Lys Gly Ile Ile Glu Gly Glu Pro Thr 
 545                550                555                560
Cys Cys Phe Glu Cys Val Glu Cys Pro Asp Gly Glu Tyr Ser Asp Glu 
                 565                570                575
Thr Asp Ala Ser Ala Cys Asn Lys Cys Pro Asp Asp Phe Trp Ser Asn 
             580                585                590
Glu Asn His Thr Ser Cys Ile Ala Lys Glu Ile Glu Phe Leu Ser Trp 
         595                600                605
Thr Glu Pro Phe Gly Ile Ala Leu Thr Leu Phe Ala Val Leu Gly Ile 
     610                615                620
Phe Leu Thr Ala Phe Val Leu Gly Val Phe Ile Lys Phe Arg Asn Thr 
 625                630                635                640
Pro Ile Val Lys Ala Thr Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe 
                 645                650                655
Ser Leu Leu Cys Cys Phe Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro 
             660                665                670
Gln Asp Trp Thr Cys Arg Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe 
         675                680                685
Val Leu Cys Ile Ser Cys Ile Leu Val Lys Thr Asn Arg Val Leu Leu 
     690                695                700
Val Phe Glu Ala Lys Ile Pro Thr Ser Phe His Arg Lys Trp Trp Gly 
 705                710                715                720
Leu Asn Leu Gln Phe Leu Leu Val Phe Leu Cys Thr Phe Met Gln Ile 
                 725                730                735
Val Ile Cys Val Ile Trp Leu Tyr Thr Ala Pro Pro Ser Ser Tyr Arg 
             740                745                750
Asn Gln Glu Leu Glu Asp Glu Ile Ile Phe Ile Thr Cys His Glu Gly 
         755                760                765
Ser Leu Met Ala Leu Gly Phe Leu Ile Gly Tyr Thr Cys Leu Leu Ala 
     770                775                780
Ala Ile Cys Phe Phe Phe Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn 
 785                790                795                800
Phe Asn Glu Ala Lys Phe Ile Thr Phe Ser Met Leu Ile Phe Phe Ile 
                 805                810                815
Val Trp Ile Ser Phe Ile Pro Ala Tyr Ala Ser Thr Tyr Gly Lys Phe 
             820                825                830
Val Ser Ala Val Glu Val Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu 
         835                840                845
Leu Ala Cys Ile Phe Phe Asn Lys Ile Tyr Ile Ile Leu Phe Lys Pro 
     850                855                860
Ser Arg Asn Thr Ile Glu Glu Val Arg Cys Ser Thr Ala Ala His Ala 
 865                870                875                880
Phe Lys Val Ala Ala Arg Ala Thr Leu Arg Arg Ser Asn Val Ser Arg 
                 885                890                895
Lys Arg Ser Ser Ser Leu Gly Gly Ser Thr Gly Ser Thr Pro Ser Ser 
             900                905                910
Ser Ile Ser Ser Lys Ser Asn Ser Glu Asp Pro Phe Pro Gln Pro Glu 
         915                920                925
Arg Gln Lys Gln Gln Gln Pro Leu Ala Leu Thr Gln Gln Glu Gln Gln 
     930                935                940
Gln Gln Pro Leu Thr Leu Pro Gln Gln Gln Arg Ser Gln Gln Gln Pro 
 945                950                955                960
Arg Cys Lys Gln Lys Val Ile Phe Gly Ser Gly Thr Val Thr Phe Ser 
                 965                970                975
Leu Ser Phe Asp Glu Pro Gln Lys Asn Ala Met Ala His Arg Asn Ser 
             980                985                990
Thr His Gln Asn Ser Leu Glu Ala Gln Lys Ser Ser Asp Thr Leu Thr 
         995                1000                1005
Arg His Gln Pro Leu Leu Pro Leu Gln Cys Gly Glu Thr Asp Leu Asp 
     1010                1015                1020
Leu Thr Val Gln Glu Thr Gly Leu Gln Gly Pro Val Gly Gly Asp Gln 
 1025                1030                1035                1040
Arg Pro Glu Val Glu Asp Pro Glu Glu Leu Ser Pro Ala Leu Val Val 
                 1045                1050                1055
Ser Ser Ser Gln Ser Phe Val Ile Ser Gly Gly Gly Ser Thr Val Thr 
             1060                1065                1070
Glu Asn Val Val Asn Ser 
         1075



<210> 8073
<211> 4113
<212> DNA
<213> Rattus norvegicus
<308> U10354
<400> 8073

cgggactct  caggccggc  caggcaccg  actgtaggt  tatttggag  gatttggag  60
ctggagacc  caggaagca  gcaggcggg  gcaggcaag  ggcggagcc  cgggcccgg  120
caaggtggc  gtcagaggg  ctgcgggga  gcagtagct  gacccaagg  gaccaggga  180
cttcagacg  tagcacgcc  ctcaaacaa  ttaacttga  atcgcaagc  gggcgggct  240
gtacgacat  ctgacttca  catccagct  ttcctgggc  gacagaggg  caacaggtg  300
tcctgtgga  gaagccagg  caaggactc  agaaaacat  tcgggcagc  tctacatga  360
gtcacttct  aggactcga  gaccagcca  cctacacct  tactacaga  aaggcagaa  420
tggagaccc  aaggccatc  ctcctgctc  gtcactaac  actctgtaa  catgtctcc  480
caccagaag  tgtgaaccg  accagggcc  tggagttct  gggctccca  tccactgac  540
cctttacct  tcccctgaa  agaaggcaa  gctatggca  cgtacagct  ctgtttggc  600
ctattggct  ttgcctggc  ctcctctgc  tatgggcct  accagcgag  ccaaaagaa  660
ggggacatt  tcctaggag  tctctttcc  atccatttt  gagtagcag  caaagatca  720
gatctgaag  caagaccag  gtctgtgga  tgcattagg  ataacttcc  tggattccg  780
tggttacaa  ccatgatat  cgccataga  gagataaac  gcagcccct  ccttcttcc  840
aacatgaca  tgggatata  gatatttga  acctgtaac  ccgtctcca  ggcgctgga  900
gccaccttg  gttttgttg  ccagaacaa  atcgattct  tgaacctgg  cgagttctg  960
aactgctct  agcacatcc  ttcgaccat  gccgtggtg  gagccaccg  ctccggtgt  1020
tccacggcg  tagccaacc  gctgggact  ttctacatc  cccaggtga  ctacgcctc  1080
tccagcagg  tcctcagca  taagaacca  tacaaatcc  tcctccgca  cattcccaa  1140
gacgaacac  aggcaaccg  gatggccga  atcatcgag  acttccgct  gaactgggt  1200
ggcacaatt  cagctgatg  cgactatgg  agacctggc  ttgagaagt  ccgagagga  1260
gccgaagag  gggatatct  cattgattt  agcgagctc  tctcccagt  ctctgacga  1320
gaagagatc  agcaggtgg  cgaagtgat  caaaactct  cggccaagg  cattgtcgt  1380
ttctccagc  gcccggacc  agaacctct  atcaaggag  ttgtgcggc  taacatcac  1440
ggcaggatc  ggctggcta  cgaggcctg  gccagttcc  cgctgattg  tatgcctga  1500
tatttccat  tagtcgggg  caccattgg  ttcggtctg  aggctgggc  gattccagg  1560
ttcagagaa  tcctacaga  agttcatcc  aggaagtct  tccacaatg  ttttgccaa  1620
gagttttgg  aagaaactt  taattgcca  ctccaagaa  gcgcaaaag  acctttacc  1680
gtggacacc  tcgtgagaa  tcacgaaga  ggtggcaac  ggttactca  tagctctac  1740
gccttccga  ccctctgca  aggggatga  aacatcaac  gtgtggaga  cccttacat  1800
gattacgaa  atttacgga  atcctacaa  gtgtactta  ccgtctact  cattgcgca  1860
gccctacaa  atatataca  ctgcttacc  ggaagaggg  ttttcacca  cgggtcctg  1920
gcagacatc  agaaggttg  ggcctggca  gtcttgaag  acctacggc  cctgaactt  1980
accaacaac  tgggggagc  ggtgacctt  gatgagtgt  gtgatctgg  ggggaacta  2040
tctatcatc  actggcacc  ctccccaga  gacggctcc  ttgtgttca  ggaagttgg  2100
tactacaat  tgtatgcca  gaagggaga  agactcttc  tcaatgagg  gaagatctt  2160
tggagtggg  tctccagag  ggtgccttt  tccaattgc  gccgggact  tcaggcagg  2220
accaggaag  ggatcatcg  gggagagcc  acctgctgc  ttgagtgtg  ggagtgtcc  2280
gatggagag  acagtggag  gacagatgc  agtgcctgt  acaagtgcc  ggatgactt  2340
tggtccaat  agaaccaca  ttcttgcat  gccaaggag  ttgagtttc  ggcgtggac  2400
gagcccttt  gaatcgctc  cactctctt  gcggtgctg  gcattttcc  gaccgcctt  2460
gtgctgggt  tcttcatca  gttccgaaa  acacctatc  tcaaggcca  caaccgaga  2520
ctgtcctac  tcctgctct  ctccctact  tgctgcttc  ccagctcct  gttcttcat  2580
ggggagccc  aggactgga  gtgccgcct  cgacagcct  ctttcggca  cagctttgt  2640
ctctgtatc  cgtgcatct  ggtgaagac  aatcgcgtc  tcctggtat  tgaagccaa  2700
atacccacc  gcttccacc  gaagtggtg  gggctcaac  tgcagttcc  gctggtttt  2760
ctctgcacc  tcatgcaga  cctcatctg  atcatctgg  tctacacgg  gcccccctc  2820
agctaccgc  accatgagc  ggaagacga  atcatcttc  tcacgtgcc  tgagggctc  2880
ctcatggca  ttggctccc  gatcggcta  acctgcctg  tggctgcca  ctgcttctt  2940
tttgccttc  agtccagga  gttaccaga  aacttcaac  aagccaagt  cattacctt  3000
agcatgctc  tcttcttca  cgtctggat  tccttcatt  cagcctatg  cagcaccta  3060
ggcaagttt  tctctgccg  agaggtgat  gccattttg  cagccagct  tggcttact  3120
gcctgcatc  tcttcaaca  ggtctacat  atcctcttc  agccttccc  gaacaccat  3180
gaggaagtc  gctccagca  cgcagcaca  gctttcaaa  tagcagccc  cgccactct  3240
cgccgtccc  acatctccc  gaagcggtc  agcagcctt  gaggctcca  cggctccat  3300
ccctcctcc  ccatcagca  caaaagcaa  agcgaagac  ggttcccgc  gccagagag  3360
cagaagcaa  agcaaccgc  gtccctgac  cagcaagaa  agcagcagc  gcccctgac  3420
ctccaccca  agcaacagc  gcagccaca  cagccgaga  gcaaacaga  ggtcatctt  3480
ggcagtggt  cggtcacct  ctctctgag  tttgacgag  ctcagaaga  tgccatggc  3540
cacaggaac  ccatgcgtc  gaactccct  gaggcccag  ggagcaacg  caccttggg  3600
agacaccag  ccctgcttc  cctacagtg  gcagatgcg  actcagaaa  gaccattca  3660
gaaacgggc  tgcaagggc  catggtggg  gaccaccag  cagaaatgg  aagctcaga  3720
gaaatgtcc  cagcgctgg  catgtccac  tctcggagc  tcgtcatta  tggtggagg  3780
agctctgtg  cggaaaacg  attacactc  taatggagg  aaaggctat  cagttgaga  3840
gtttttctt  gagccctga  caaaaggat  ggtccttcc  ttcttccca  gaagccagg  3900
agagtaggt  cgtcaaagc  tgtactcag  tgcactgct  tgaatgaca  tgaactgac  3960
ggtgtgctc  ttagagtta  aagaagagc  atgttttgg  gtcgttttc  agagctcag  4020
atcacacct  ggtttgctg  agtcttttc  tctgctcta  ccaccatca  ttcagacga  4080
agcaaggct  taagctacc  atctgcttc  ctc  4113



<210> 8074
<211> 1079
<212> PRT
<213> Rattus norvegicus
<308> P48442
<400> 8074

Met Ala Ser Tyr Ser Cys Cys Leu Ala Leu Leu Ala Leu Ala Trp His 
  1               5                  10                  15
Ser Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
             20                  25                  30
Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp 
         35                  40                  45
Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn 
     50                  55                  60
Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu 
 65                  70                  75                  80
Ile Asn Ser Ser Pro Ser Leu Leu Pro Asn Met Thr Leu Gly Tyr Arg 
                 85                  90                  95
Ile Phe Asp Thr Cys Asn Thr Val Ser Lys Ala Leu Glu Ala Thr Leu 
             100                105                110
Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe 
         115                120                125
Cys Asn Cys Ser Glu His Ile Pro Ser Thr Ile Ala Val Val Gly Ala 
     130                135                140
Thr Gly Ser Gly Val Ser Thr Ala Val Ala Asn Leu Leu Gly Leu Phe 
 145                150                155                160
Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn 
                 165                170                175
Lys Asn Gln Tyr Lys Ser Phe Leu Arg Thr Ile Pro Asn Asp Glu His 
             180                185                190
Gln Ala Thr Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp 
         195                200                205
Val Gly Thr Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu 
     210                215                220
Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser 
 225                230                235                240
Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln Gln Val Val 
                 245                250                255
Glu Val Ile Gln Asn Ser Thr Ala Lys Val Ile Val Val Phe Ser Ser 
             260                265                270
Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile 
         275                280                285
Thr Gly Arg Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu 
     290                295                300
Ile Ala Met Pro Glu Tyr Phe His Val Val Gly Gly Thr Ile Gly Phe 
 305                310                315                320
Gly Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Gln Lys 
                 325                330                335
Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp 
             340                345                350
Glu Glu Thr Phe Asn Cys His Leu Gln Glu Gly Ala Lys Gly Pro Leu 
         355                360                365
Pro Val Asp Thr Phe Val Arg Ser His Glu Glu Gly Gly Asn Arg Leu 
     370                375                380
Leu Asn Ser Ser Thr Ala Phe Arg Pro Leu Cys Thr Gly Asp Glu Asn 
 385                390                395                400
Ile Asn Ser Val Glu Thr Pro Tyr Met Asp Tyr Glu His Leu Arg Ile 
                 405                410                415
Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln 
             420                425                430
Asp Ile Tyr Thr Cys Leu Pro Gly Arg Gly Leu Phe Thr Asn Gly Ser 
         435                440                445
Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu 
     450                455                460
Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu Gln Val Thr Phe Asp 
 465                470                475                480
Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu 
                 485                490                495
Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn 
             500                505                510
Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys Ile 
         515                520                525
Leu Trp Ser Gly Phe Ser Arg Glu Val Pro Phe Ser Asn Cys Ser Arg 
     530                535                540
Asp Cys Gln Ala Gly Thr Arg Lys Gly Ile Ile Glu Gly Glu Pro Thr 
 545                550                555                560
Cys Cys Phe Glu Cys Val Glu Cys Pro Asp Gly Glu Tyr Ser Gly Glu 
                 565                570                575
Thr Asp Ala Ser Ala Cys Asp Lys Cys Pro Asp Asp Phe Trp Ser Asn 
             580                585                590
Glu Asn His Thr Ser Cys Ile Ala Lys Glu Ile Glu Phe Leu Ala Trp 
         595                600                605
Thr Glu Pro Phe Gly Ile Ala Leu Thr Leu Phe Ala Val Leu Gly Ile 
     610                615                620
Phe Leu Thr Ala Phe Val Leu Gly Val Phe Ile Lys Phe Arg Asn Thr 
 625                630                635                640
Pro Ile Val Lys Ala Thr Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe 
                 645                650                655
Ser Leu Leu Cys Cys Phe Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro 
             660                665                670
Gln Asp Trp Thr Cys Arg Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe 
         675                680                685
Val Leu Cys Ile Ser Cys Ile Leu Val Lys Thr Asn Arg Val Leu Leu 
     690                695                700
Val Phe Glu Ala Lys Ile Pro Thr Ser Phe His Arg Lys Trp Trp Gly 
 705                710                715                720
Leu Asn Leu Gln Phe Leu Leu Val Phe Leu Cys Thr Phe Met Gln Ile 
                 725                730                735
Leu Ile Cys Ile Ile Trp Leu Tyr Thr Ala Pro Pro Ser Ser Tyr Arg 
             740                745                750
Asn His Glu Leu Glu Asp Glu Ile Ile Phe Ile Thr Cys His Glu Gly 
         755                760                765
Ser Leu Met Ala Leu Gly Ser Leu Ile Gly Tyr Thr Cys Leu Leu Ala 
     770                775                780
Ala Ile Cys Phe Phe Phe Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn 
 785                790                795                800
Phe Asn Glu Ala Lys Phe Ile Thr Phe Ser Met Leu Ile Phe Phe Ile 
                 805                810                815
Val Trp Ile Ser Phe Ile Pro Ala Tyr Ala Ser Thr Tyr Gly Lys Phe 
             820                825                830
Val Ser Ala Val Glu Val Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu 
         835                840                845
Leu Ala Cys Ile Phe Phe Asn Lys Val Tyr Ile Ile Leu Phe Lys Pro 
     850                855                860
Ser Arg Asn Thr Ile Glu Glu Val Arg Ser Ser Thr Ala Ala His Ala 
 865                870                875                880
Phe Lys Val Ala Ala Arg Ala Thr Leu Arg Arg Pro Asn Ile Ser Arg 
                 885                890                895
Lys Arg Ser Ser Ser Leu Gly Gly Ser Thr Gly Ser Ile Pro Ser Ser 
             900                905                910
Ser Ile Ser Ser Lys Ser Asn Ser Glu Asp Arg Phe Pro Gln Pro Glu 
         915                920                925
Arg Gln Lys Gln Gln Gln Pro Leu Ser Leu Thr Gln Gln Glu Gln Gln 
     930                935                940
Gln Gln Pro Leu Thr Leu His Pro Gln Gln Gln Gln Gln Pro Gln Gln 
 945                950                955                960
Pro Arg Cys Lys Gln Lys Val Ile Phe Gly Ser Gly Thr Val Thr Phe 
                 965                970                975
Ser Leu Ser Phe Asp Glu Pro Gln Lys Asn Ala Met Ala His Arg Asn 
             980                985                990
Ser Met Arg Gln Asn Ser Leu Glu Ala Gln Arg Ser Asn Asp Thr Leu 
         995                1000                1005
Gly Arg His Gln Ala Leu Leu Pro Leu Gln Cys Ala Asp Ala Asp Ser 
     1010                1015                1020
Glu Met Thr Ile Gln Glu Thr Gly Leu Gln Gly Pro Met Val Gly Asp 
 1025                1030                1035                1040
His Gln Pro Glu Met Glu Ser Ser Asp Glu Met Ser Pro Ala Leu Val 
                 1045                1050                1055
Met Ser Thr Ser Arg Ser Phe Val Ile Ser Gly Gly Gly Ser Ser Val 
             1060                1065                1070
Thr Glu Asn Val Leu His Ser 
         1075



<210> 8075
<211> 5009
<212> DNA
<213> Homo sapiens
<308> U20760
<400> 8075

ggggctgct  tggccggac  cgaaggcgg  cgccgggag  gcagcgagc  agacgcgcc  60
ctccaagac  gtgaccttg  catagggag  ggggctgcg  gcagtcctg  gatcagacc  120
gagctcatc  tcgtggaga  ccacggccg  ggggccgga  ctgcctctg  gcgagggag  180
cctggccgc  gcgcagaag  catcacagg  ggcctctgc  tgatgtggc  tccaaagac  240
caaggacca  ccacattac  agtctggat  gaggaaggc  gaaatggag  ttcaaacac  300
acgtcttct  ttattttat  aatcaatct  tagacatgt  tccccactg  agggagtga  360
ctgctccaa  ggagaaact  ctgggagcc  ccaaactcc  agctgtctc  tcccttgcc  420
tggagagac  gcagaacca  ggcatttta  agctgctgc  gggtcctct  ggcactcac  480
tggcacacc  ctgcctacg  gccagacca  cgagcccaa  agaaggggg  cattatcct  540
ggggggctc  ttcctattc  ttttggagt  gcagctaaa  atcaagatc  caaatcaag  600
ccggagtct  tggaatgta  caggtataa  ttccgtggg  ttcgctggt  acaggctat  660
atatttgcc  tagaggaga  aaacagcag  ccagccctt  ttcccaact  gacgctggg  720
tacaggata  ttgacactt  caacaccgt  tctaaggcc  tggaagcca  cctgagttt  780
gttgctcaa  acaaaattg  ttctttgaa  cttgatgag  tctgcaact  ctcagagca  840
attccctct  cgattgctg  ggtgggagc  actggctca  gcgtctcca  ggcagtggc  900
aatctgctg  ggctcttct  cattcccca  gtcagttat  cctcctcca  cagactcct  960
agcaacaag  atcaattca  gtctttcct  cgaaccatc  ccaatgatg  gcaccaggc  1020
actgccatg  cagacatca  cgagtattt  cgctggaac  gggtgggca  aattgcagc  1080
gatgacgac  atgggcggc  ggggattga  aaattccga  aggaagctg  ggaaaggga  1140
atctgcatc  acttcagtg  actcatctc  cagtactct  atgaggaag  gatccagca  1200
gtggtagag  tgattcaaa  ttccacggc  aaagtcatc  tggttttct  cagtggccc  1260
gatcttgag  ccctcatca  ggagattgt  cggcgcaat  tcacgggca  gatctggct  1320
gccagcgag  cctgggcca  ctcctccct  atcgccatg  ctcagtact  ccacgtggt  1380
ggcggcacc  ttggattcg  tctgaaggc  gggcagatc  caggcttcc  ggaattcct  1440
aagaaggtc  atcccagga  gtctgtcca  aatggtttt  ccaaggagt  ttgggaaga  1500
acatttaac  gccacctcc  agaaggtgc  aaaggacct  tacctgtgg  cacctttct  1560
agaggtcac  aagaaagtg  cgacaggtt  agcaacagc  cgacagcct  ccgacccct  1620
tgtacaggg  atgagaaca  cagcagtgt  gagacccct  acatagatt  cacgcattt  1680
cggatatcc  acaatgtgt  cttagcagt  tactccatt  cccacgcct  gcaagatat  1740
tatacctgc  tacctggga  agggctctt  accaatggc  cctgtgcag  catcaagaa  1800
gttgaggcg  ggcaggtcc  gaagcacct  cggcatcta  actttacaa  caatatggg  1860
gagcaggtg  cctttgatg  gtgtggtga  ctggtgggg  actattcca  catcaactg  1920
cacctctcc  cagaggatg  ctccatcgt  tttaaggaa  tcgggtatt  caacgtcta  1980
gccaagaag  gagaaagac  cttcatcaa  gaggagaaa  tcctgtgga  tgggttctc  2040
agggagcca  tcacctttg  gctgtctgt  ctccaggtg  ccttctcca  ctgcagccg  2100
gactgcctg  cagggacca  gaaagggat  attgagggg  agcccacct  ctgctttga  2160
tgtgtggag  gtcctgatg  ggagtatag  gatgagaca  atgccagtg  ctgtaacaa  2220
tgcccagat  acttctggt  caatgagaa  cacacctcc  gcattgcca  ggagatcga  2280
tttctgtcg  ggacggagc  ctttgggat  gcactcacc  tctttgccg  gctgggcat  2340
ttcctgaca  cctttgtgc  gggtgtgtt  atcaagttc  gcaacacac  cattgtcaa  2400
gccaccaac  gagagctct  ctacctcct  ctcttctcc  tgctctgct  cttctccag  2460
tccctgttc  tcatcgggg  gccccagga  tggacgtgc  gcctgcgcc  gccggcctt  2520
ggcatcagc  tcgtgctct  catctcatg  atcctggtg  aaaccaacc  tgtcctcct  2580
gtgtttgag  ccaagatcc  caccagctt  caccgcaag  ggtgggggc  caacctgca  2640
ttcctgctg  ttttcctct  caccttcat  cagattgtc  tctgtgtga  ctggctcta  2700
accgcgccc  cctcaagct  ccgcaacca  gagctggag  atgagatca  cttcatcac  2760
tgccacgag  gctccctca  ggccctggg  ttcctgatc  gctacacct  cctgctggc  2820
gccatctgc  tcttctttg  cttcaagtc  cggaagctg  cggagaact  caatgaagc  2880
aagttcatc  ccttcagca  gctcatctt  ttcatcgtc  ggatctcct  cattccagc  2940
tatgccagc  cctatggca  gtttgtctc  gccgtagag  tgattgcca  cctggcagc  3000
agctttggc  tgctggcgt  catcttctt  aacaagatc  acatcattc  cttcaagcc  3060
tcccgcaac  ccatcgagg  ggtgcgttg  agcaccgca  ctcacgctt  caaggtggc  3120
gcccgggcc  cgctgcgcc  cagcaacgt  tcccgcaag  ggtccagca  ccttggagg  3180
tccacggga  ccaccccct  ctcctccat  agcagcaag  gcaacagcg  agacccatt  3240
ccacggccc  agaggcaga  gcagcagca  ccgctggcc  taacccagc  agagcagca  3300
cagcagccc  tgaccctcc  acagcagca  cgatctcag  agcagccca  atgcaagca  3360
aaggtcatc  ttggcagcg  cacggtcac  ttctcactg  gctttgatg  gcctcagaa  3420
aacgccatg  cccacagga  ttctacgca  cagaactcc  tggaggccc  gaaaagcag  3480
gatacgctg  cccgacacc  gccattact  ccgctgcag  gcggggaaa  ggacttaga  3540
ctgaccgtc  aggaaacag  tctgcaagg  cctgtgggt  gagaccagc  gccagaggt  3600
gaggaccct  aagagttgt  cccagcact  gtagtgtcc  gttcacaga  ctttgtcat  3660
agtggtgga  gcagcactg  tacagaaaa  gtagtgaat  cataaaatg  aaggagaag  3720
ctgggctag  gagaatgca  agaggtttc  tggggtccc  gggatgagg  atcgcccca  3780
actcctttc  tctgaggaa  aagggataa  agacacatc  aatgccccg  atttagtca  3840
accatctta  atgacagtg  attgaccca  gttcccttt  aaattaaaa  aaagaagag  3900
cttgtgttt  tgtggttgc  tttgtcaaa  cattgagat  tccacggtc  gatttgctg  3960
tcacccaca  ctaatgtct  ttcctctgt  ctatcccac  caacagctc  gagatgaaa  4020
tatggcttt  aactaccct  cagagtgtg  agactgatg  gacatcaaa  ttgccacca  4080
tagagctga  agtctgaaa  acagaatgt  accagtcct  cccaatgcc  tgacaacag  4140
ctgaatttt  aatgttcac  acataagga  aatgtatct  ctcctattt  tgaaaacca  4200
atgatattt  gtctcctac  tgctgctgc  attatgtaa  atccagaag  tttgcaccc  4260
tcctatacc  tatgtctgg  tctgtccag  acatgatac  gatgccatg  ttagattcc  4320
ggatcacaa  aatcacctc  aattgttag  aagggactg  ataaaccaa  gagctgtat  4380
tgtaattaa  attcctata  gtagcttta  ccttaggaa  atgcttctg  tgtaatagt  4440
catggacaa  ataaactga  aaatgtcag  ctggtttat  taaggcagt  ttattgagc  4500
ctatttccc  accccacta  cctcactcc  ataagctaa  ccttatgtg  gccccttca  4560
ggactcaag  gtccagaag  ccctcccat  tctacccca  agaattcct  aagccagat  4620
caccctatc  ctgtacaga  taagttctc  attattggc  tgctaatag  tgctagggt  4680
ggaaagcgt  gttccaaga  agatccacc  tcaaatgtc  gagctatgt  ccctccagc  4740
gtggtatta  tactgccgg  cacccaggc  ctggagcca  agagacaga  cggggttca  4800
gccatggct  cgtcatttg  aagctgagt  actgtaggc  gggaacctt  acctctcta  4860
gccacagct  cttcatctt  aaaataagg  taataatca  tccttcccc  cagagctct  4920
atgtggatt  aacgagata  tgtatataa  gtactttag  ctggtacct  gcacacaat  4980
agcattcaa  aaatattag  taatattat  5009



<210> 8076
<211> 1078
<212> PRT
<213> Homo sapiens
<308> P41180
<400> 8076

Met Ala Phe Tyr Ser Cys Cys Trp Val Leu Leu Ala Leu Thr Trp His 
  1               5                  10                  15
Thr Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
             20                  25                  30
Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp 
         35                  40                  45
Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn 
     50                  55                  60
Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu 
 65                  70                  75                  80
Ile Asn Ser Ser Pro Ala Leu Leu Pro Asn Leu Thr Leu Gly Tyr Arg 
                 85                  90                  95
Ile Phe Asp Thr Cys Asn Thr Val Ser Lys Ala Leu Glu Ala Thr Leu 
             100                105                110
Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe 
         115                120                125
Cys Asn Cys Ser Glu His Ile Pro Ser Thr Ile Ala Val Val Gly Ala 
     130                135                140
Thr Gly Ser Gly Val Ser Thr Ala Val Ala Asn Leu Leu Gly Leu Phe 
 145                150                155                160
Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn 
                 165                170                175
Lys Asn Gln Phe Lys Ser Phe Leu Arg Thr Ile Pro Asn Asp Glu His 
             180                185                190
Gln Ala Thr Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp 
         195                200                205
Val Gly Thr Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu 
     210                215                220
Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser 
 225                230                235                240
Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln His Val Val 
                 245                250                255
Glu Val Ile Gln Asn Ser Thr Ala Lys Val Ile Val Val Phe Ser Ser 
             260                265                270
Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile 
         275                280                285
Thr Gly Lys Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu 
     290                295                300
Ile Ala Met Pro Gln Tyr Phe His Val Val Gly Gly Thr Ile Gly Phe 
 305                310                315                320
Ala Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Lys Lys 
                 325                330                335
Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp 
             340                345                350
Glu Glu Thr Phe Asn Cys His Leu Gln Glu Gly Ala Lys Gly Pro Leu 
         355                360                365
Pro Val Asp Thr Phe Leu Arg Gly His Glu Glu Ser Gly Asp Arg Phe 
     370                375                380
Ser Asn Ser Ser Thr Ala Phe Arg Pro Leu Cys Thr Gly Asp Glu Asn 
 385                390                395                400
Ile Ser Ser Val Glu Thr Pro Tyr Ile Asp Tyr Thr His Leu Arg Ile 
                 405                410                415
Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln 
             420                425                430
Asp Ile Tyr Thr Cys Leu Pro Gly Arg Gly Leu Phe Thr Asn Gly Ser 
         435                440                445
Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu 
     450                455                460
Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu Gln Val Thr Phe Asp 
 465                470                475                480
Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu 
                 485                490                495
Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn 
             500                505                510
Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys Ile 
         515                520                525
Leu Trp Ser Gly Phe Ser Arg Glu Val Pro Phe Ser Asn Cys Ser Arg 
     530                535                540
Asp Cys Leu Ala Gly Thr Arg Lys Gly Ile Ile Glu Gly Glu Pro Thr 
 545                550                555                560
Cys Cys Phe Glu Cys Val Glu Cys Pro Asp Gly Glu Tyr Ser Asp Glu 
                 565                570                575
Thr Asp Ala Ser Ala Cys Asn Lys Cys Pro Asp Asp Phe Trp Ser Asn 
             580                585                590
Glu Asn His Thr Ser Cys Ile Ala Lys Glu Ile Glu Phe Leu Ser Trp 
         595                600                605
Thr Glu Pro Phe Gly Ile Ala Leu Thr Leu Phe Ala Val Leu Gly Ile 
     610                615                620
Phe Leu Thr Ala Phe Val Leu Gly Val Phe Ile Lys Phe Arg Asn Thr 
 625                630                635                640
Pro Ile Val Lys Ala Thr Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe 
                 645                650                655
Ser Leu Leu Cys Cys Phe Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro 
             660                665                670
Gln Asp Trp Thr Cys Arg Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe 
         675                680                685
Val Leu Cys Ile Ser Cys Ile Leu Val Lys Thr Asn Arg Val Leu Leu 
     690                695                700
Val Phe Glu Ala Lys Ile Pro Thr Ser Phe His Arg Lys Trp Trp Gly 
 705                710                715                720
Leu Asn Leu Gln Phe Leu Leu Val Phe Leu Cys Thr Phe Met Gln Ile 
                 725                730                735
Val Ile Cys Val Ile Trp Leu Tyr Thr Ala Pro Pro Ser Ser Tyr Arg 
             740                745                750
Asn Gln Glu Leu Glu Asp Glu Ile Ile Phe Ile Thr Cys His Glu Gly 
         755                760                765
Ser Leu Met Ala Leu Gly Phe Leu Ile Gly Tyr Thr Cys Leu Leu Ala 
     770                775                780
Ala Ile Cys Phe Phe Phe Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn 
 785                790                795                800
Phe Asn Glu Ala Lys Phe Ile Thr Phe Ser Met Leu Ile Phe Phe Ile 
                 805                810                815
Val Trp Ile Ser Phe Ile Pro Ala Tyr Ala Ser Thr Tyr Gly Lys Phe 
             820                825                830
Val Ser Ala Val Glu Val Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu 
         835                840                845
Leu Ala Cys Ile Phe Phe Asn Lys Ile Tyr Ile Ile Leu Phe Lys Pro 
     850                855                860
Ser Arg Asn Thr Ile Glu Glu Val Arg Cys Ser Thr Ala Ala His Ala 
 865                870                875                880
Phe Lys Val Ala Ala Arg Ala Thr Leu Arg Arg Ser Asn Val Ser Arg 
                 885                890                895
Lys Arg Ser Ser Ser Leu Gly Gly Ser Thr Gly Ser Thr Pro Ser Ser 
             900                905                910
Ser Ile Ser Ser Lys Ser Asn Ser Glu Asp Pro Phe Pro Gln Pro Glu 
         915                920                925
Arg Gln Lys Gln Gln Gln Pro Leu Ala Leu Thr Gln Gln Glu Gln Gln 
     930                935                940
Gln Gln Pro Leu Thr Leu Pro Gln Gln Gln Arg Ser Gln Gln Gln Pro 
 945                950                955                960
Arg Cys Lys Gln Lys Val Ile Phe Gly Ser Gly Thr Val Thr Phe Ser 
                 965                970                975
Leu Ser Phe Asp Glu Pro Gln Lys Asn Ala Met Ala His Arg Asn Ser 
             980                985                990
Thr His Gln Asn Ser Leu Glu Ala Gln Lys Ser Ser Asp Thr Leu Thr 
         995                1000                1005
Arg His Gln Pro Leu Leu Pro Leu Gln Cys Gly Glu Thr Asp Leu Asp 
     1010                1015                1020
Leu Thr Val Gln Glu Thr Gly Leu Gln Gly Pro Val Gly Gly Asp Gln 
 1025                1030                1035                1040
Arg Pro Glu Val Glu Asp Pro Glu Glu Leu Ser Pro Ala Leu Val Val 
                 1045                1050                1055
Ser Ser Ser Gln Ser Phe Val Ile Ser Gly Gly Gly Ser Thr Val Thr 
             1060                1065                1070
Glu Asn Val Val Asn Ser 
         1075



<210> 8077
<211> 2207
<212> DNA
<213> Rattus norvegicus
<308> U10357
<400> 8077

gtctcccgg  tgtgcttgg  cgtgcggag  gccggtgcc  gcacctcca  ctccgggac  60
gcagcggga  ccaagcccg  gccgcaggc  tcgtcgcca  gcgctggtt  cgggcgctg  120
tgaagaatg  gtccctggc  ggggcgccc  agtacatcg  gcacttcag  aagttctcc  180
cgtccccgc  gtccatgaa  cagtttcta  acttcggat  cagcaatgc  tgcgagaaa  240
cttcattca  cttcctccg  caggagctg  ccgtgcgcc  ggccaacat  atgaaagag  300
tcaacctgc  tcctgaccg  gtgctgagc  ccccctcag  gcaactggt  cagagctgg  360
atgtccaga  tctgctgga  atcatggaa  tcctggaca  ggaccccga  gaccaccgg  420
ccctaagcc  gttcactga  gccctggtc  ccatccgga  ccggcacaa  gacgtagtg  480
ccaccatgg  acagggagt  ttggagtac  aggacacct  tggtgatga  ccagtctcc  540
accagaaca  ccagtactt  ttggaccgc  tctacctca  ccgcatctc  atccgcatg  600
tcattaacc  gcacaccct  atctttgat  gcagcacca  cccagccca  cccaaacac  660
ttggcagca  tgatcccaa  tgcagcgtg  ctgatgtgg  gaaagatgc  tatgacatg  720
ctaagctcc  gtgtgacaa  tattacatg  cttcccctg  cctggagat  caggaagtc  780
atgccacca  cgccaccca  cccattcac  tggtctacg  cccctccca  ctctaccac  840
tgctctttg  actcttcaa  aatgccatg  gggccacag  ggaaagcca  gagtccagc  900
tcactctcc  tcccatcaa  atcatggtg  ccctcggtg  agaagatct  tccatcaaa  960
tgagtgacc  aggcggggg  gtccccttg  ggaagatcg  gaggctctt  agctacatg  1020
actctacag  tcctacacc  cagcctggc  ctgggggta  cccgctggc  ggctttggg  1080
atggactcc  catttcccg  ctctacgcc  agtacttcc  gggggactt  cagctcttc  1140
ctatggagg  ctttgggac  gatgctgtc  tctatctga  ggccctgtc  acggactca  1200
tggagcgcc  gcctgtcta  aacaagtct  cctggcgcc  ctaccagac  atccaggag  1260
ccggtgact  gtgcgtgcc  agcacagag  ccaagaaca  atcgacgta  cgggtcagc  1320
aggggcctt  tcttcctgg  acctgggag  atgctgcca  ctctgaatc  agccaccac  1380
gggacttcc  tatctatcc  ctggggtac  ggggtgaaa  tgggtctcc  cgatggcca  1440
atctgtctt  gtagaaatc  cagtggccc  tctgtggcg  tccctaagt  ccaatctgt  1500
tctatggag  aacctaggg  gtttccctg  agcctggtc  ccatggtga  gatgcttga  1560
ggttgggga  ggctctacc  ggtggggtg  ccccagaga  acttctccc  agaccagag  1620
tgtctgttt  ctaccagaa  ccctgggtc  ccctcactg  ctgcatagt  ctggtctcc  1680
acgtggctg  ctcgcttgc  ttatgccca  accctgtac  ggcacattg  gctggtttc  1740
tcgtcagta  taagaaaga  ggagagaga  tggggaaac  ggggccaac  ttgtctctg  1800
tcctgcagc  tctctccat  tccactctg  acactaaag  tgccactgg  aacttgaga  1860
tgggtggcc  ttctcaccc  aggcccacc  agaaggcct  agagtaacc  gtccccaag  1920
cgatcttag  aatgtttct  ccgcttcct  gcctggcat  tcctcacgt  tatacctcc  1980
ctgcccagt  tacgctcac  ctatccctg  ttgagcttt  gaccccaga  ttcctatgc  2040
cactatgtg  gcacagacg  ctcaaaccc  ggatgcccc  tgtacatag  cagttttgt  2100
atctcagat  cctcaccct  gccctccgc  cacaggggt  aaagccgtg  gcccctccc  2160
gtggctggg  tggtgacag  gacatccac  gtaaataga  gaaatga  2207



<210> 8078
<211> 407
<212> PRT
<213> Rattus norvegicus
<308> Q64536
<400> 8078

Met Arg Trp Phe Arg Ala Leu Leu Lys Asn Ala Ser Leu Ala Gly Ala 
  1               5                  10                  15
Pro Lys Tyr Ile Glu His Phe Ser Lys Phe Ser Pro Ser Pro Leu Ser 
             20                  25                  30
Met Lys Gln Phe Leu Asp Phe Gly Ser Ser Asn Ala Cys Glu Lys Thr 
         35                  40                  45
Ser Phe Thr Phe Leu Arg Gln Glu Leu Pro Val Arg Leu Ala Asn Ile 
     50                  55                  60
Met Lys Glu Ile Asn Leu Leu Pro Asp Arg Val Leu Ser Thr Pro Ser 
 65                  70                  75                  80
Val Gln Leu Val Gln Ser Trp Tyr Val Gln Ser Leu Leu Asp Ile Met 
                 85                  90                  95
Glu Phe Leu Asp Lys Asp Pro Glu Asp His Arg Thr Leu Ser Gln Phe 
             100                105                110
Thr Asp Ala Leu Val Thr Ile Arg Asn Arg His Asn Asp Val Val Pro 
         115                120                125
Thr Met Ala Gln Gly Val Leu Glu Tyr Lys Asp Thr Tyr Gly Asp Asp 
     130                135                140
Pro Val Ser Asn Gln Asn Ile Gln Tyr Phe Leu Asp Arg Phe Tyr Leu 
 145                150                155                160
Ser Arg Ile Ser Ile Arg Met Leu Ile Asn Gln His Thr Leu Ile Phe 
                 165                170                175
Asp Gly Ser Thr Asn Pro Ala His Pro Lys His Ile Gly Ser Ile Asp 
             180                185                190
Pro Asn Cys Ser Val Ser Asp Val Val Lys Asp Ala Tyr Asp Met Ala 
         195                200                205
Lys Leu Leu Cys Asp Lys Tyr Tyr Met Ala Ser Pro Asp Leu Glu Ile 
     210                215                220
Gln Glu Val Asn Ala Thr Asn Ala Thr Gln Pro Ile His Met Val Tyr 
 225                230                235                240
Val Pro Ser His Leu Tyr His Met Leu Phe Glu Leu Phe Lys Asn Ala 
                 245                250                255
Met Arg Ala Thr Val Glu Ser His Glu Ser Ser Leu Thr Leu Pro Pro 
             260                265                270
Ile Lys Ile Met Val Ala Leu Gly Glu Glu Asp Leu Ser Ile Lys Met 
         275                280                285
Ser Asp Arg Gly Gly Gly Val Pro Leu Arg Lys Ile Glu Arg Leu Phe 
     290                295                300
Ser Tyr Met Tyr Ser Thr Ala Pro Thr Pro Gln Pro Gly Thr Gly Gly 
 305                310                315                320
Thr Pro Leu Ala Gly Phe Gly Tyr Gly Leu Pro Ile Ser Arg Leu Tyr 
                 325                330                335
Ala Lys Tyr Phe Gln Gly Asp Leu Gln Leu Phe Ser Met Glu Gly Phe 
             340                345                350
Gly Thr Asp Ala Val Ile Tyr Leu Lys Ala Leu Ser Thr Asp Ser Val 
         355                360                365
Glu Arg Leu Pro Val Tyr Asn Lys Ser Ala Trp Arg His Tyr Gln Thr 
     370                375                380
Ile Gln Glu Ala Gly Asp Trp Cys Val Pro Ser Thr Glu Pro Lys Asn 
 385                390                395                400
Thr Ser Thr Tyr Arg Val Ser 
                 405



<210> 8079
<211> 2260
<212> DNA
<213> Homo sapiens
<308> NM_002611
<400> 8079

ggcacgagg  agcgctgcc  gcgcgggga  cacaaccca  gtcgcggcc  ccgcagcca  60
gcgctgggt  tgggcgctg  tgaagaatg  gtccctggc  ggggcgccc  agtacatag  120
gcacttcag  aagttctcc  cgtccccgc  gtccatgaa  cagtttctg  acttcggat  180
cagcaatgc  tgtgagaaa  cctccttca  cttcctcag  caggagctg  ctgtgcgcc  240
ggccaacat  atgaaagag  tcaacctgc  tcccgaccg  gtgctgagc  caccctccg  300
gcagctggt  cagagctgg  atgtccaga  cctcctgga  atcatggag  tcctggaca  360
ggatcccga  gaccatcgc  ccctgagcc  gttcactga  gccctggtc  ccatccgga  420
ccggcacaa  gacgtggtg  ccaccatgg  acaaggcgt  cttgagtac  aggacacct  480
cggcgatga  cccgtctcc  accagaaca  ccagtactt  ctggaccgc  tctacctca  540
ccgcatctc  atccgcatg  tcatcaacc  gcacaccct  atctttgat  gcagcacca  600
cccagccca  cccaaacac  tcggcagca  cgaccccaa  tgcaacgtc  ctgaggtgg  660
caaagatgc  tacgacatg  ctaagctcc  gtgtgacaa  tattacatg  cctcacctg  720
cctggagat  caggagatc  atgcagcca  ctccaaaca  ccgattcac  tggtctacg  780
cccctccca  ctctaccac  tgctctttg  gctcttcaa  aatgccatg  gggcgactg  840
ggaaagcca  gagtccagc  tcattctcc  acccatcaa  gtcatggtg  ccttgggtg  900
ggaagatct  tccatcaag  tgagtgacc  aggtggggg  gttcccttg  ggaagattg  960
gcgactctt  agctacatg  actccacag  acccacccc  cagcctggc  ccgggggaa  1020
gccgctggc  ggctttggt  atgggctcc  catttcccg  ctctacgcc  agtacttcc  1080
gggagacct  cagctcttc  ccatggaag  ctttgggac  gatgctgtc  tctatctca  1140
ggccctgtc  acggactcg  tggagcgcc  gcctgtcta  aacaagtca  cctggcgcc  1200
ctaccagac  atccaggag  ccggcgact  gtgtgtgcc  agcacggag  ccaagaaca  1260
gtccacgta  cgcgtcagc  aagggccgc  gtgcatctg  acctgagag  acggactgc  1320
gcctctggg  ccccccacc  tggtgcccc  caccatcct  ctgggggag  agggggtgg  1380
ttctccctg  tgaccaggt  ctgtctcta  gcaagtcac  gcggtgata  gtctgtgat  1440
gtccctaag  gccagtcca  ctctgtgga  acccctcgg  ggcctccct  tctctgtgg  1500
cgatgcctg  gggttaggg  tgtctccac  ctgatgggg  gtcccagag  cattttccc  1560
tggcagtcc  cctctctga  accagggct  tcacttttc  gccaggggt  ctgggtccc  1620
ctcagcacc  tccacagca  aggccttcc  agtggatgt  ccgttgcct  attccccca  1680
cccacaaag  caccctggc  ttggtctgc  gaagtgtta  gaagagggt  ggtgccctc  1740
agacctggg  actgagtgg  gaaaggagt  acacccgtg  gtggggaat  aggctggtc  1800
tgcagcctc  ccctccgct  agggcttga  ggtcggtgg  ggagggggt  gctctcaca  1860
ggcccaact  taaagtgga  gaaccttgt  agaccgaga  cttgccatc  agccaagct  1920
ctcgaggcc  tgcagtggc  ttggcaatg  ctgtgccac  tcctgagcc  tcccagcat  1980
tcctcacat  ctcatgccc  cccgctcct  cacaagcct  gtccatcct  cctgagctc  2040
agcccccag  ccccactgt  cccagacat  tgtgctcag  gtggctttc  ccctaggac  2100
ttctgtgta  atagttagt  ttataaccc  gaatgcccc  acccttccc  taagcacac  2160
ggggttaaa  ctgtgtgtc  ctcccagtg  ctgtggcag  gacagtgac  cccacaccc  2220
cagtaaaga  gagactgaa  gaaaaaaaa  aaaaaaaaaa  2260



<210> 8080
<211> 407
<212> PRT
<213> Homo sapiens
<308> Q15119
<400> 8080

Met Arg Trp Val Trp Ala Leu Leu Lys Asn Ala Ser Leu Ala Gly Ala 
  1               5                  10                  15
Pro Lys Tyr Ile Glu His Phe Ser Lys Phe Ser Pro Ser Pro Leu Ser 
             20                  25                  30
Met Lys Gln Phe Leu Asp Phe Gly Ser Ser Asn Ala Cys Glu Lys Thr 
         35                  40                  45
Ser Phe Thr Phe Leu Arg Gln Glu Leu Pro Val Arg Leu Ala Asn Ile 
     50                  55                  60
Met Lys Glu Ile Asn Leu Leu Pro Asp Arg Val Leu Ser Thr Pro Ser 
 65                  70                  75                  80
Val Gln Leu Val Gln Ser Trp Tyr Val Gln Ser Leu Leu Asp Ile Met 
                 85                  90                  95
Glu Phe Leu Asp Lys Asp Pro Glu Asp His Arg Thr Leu Ser Gln Phe 
             100                105                110
Thr Asp Ala Leu Val Thr Ile Arg Asn Arg His Asn Asp Val Val Pro 
         115                120                125
Thr Met Ala Gln Gly Val Leu Glu Tyr Lys Asp Thr Tyr Gly Asp Asp 
     130                135                140
Pro Val Ser Asn Gln Asn Ile Gln Tyr Phe Leu Asp Arg Phe Tyr Leu 
 145                150                155                160
Ser Arg Ile Ser Ile Arg Met Leu Ile Asn Gln His Thr Leu Ile Phe 
                 165                170                175
Asp Gly Ser Thr Asn Pro Ala His Pro Lys His Ile Gly Ser Ile Asp 
             180                185                190
Pro Asn Cys Asn Val Ser Glu Val Val Lys Asp Ala Tyr Asp Met Ala 
         195                200                205
Lys Leu Leu Cys Asp Lys Tyr Tyr Met Ala Ser Pro Asp Leu Glu Ile 
     210                215                220
Gln Glu Ile Asn Ala Ala Asn Ser Lys Gln Pro Ile His Met Val Tyr 
 225                230                235                240
Val Pro Ser His Leu Tyr His Met Leu Phe Glu Leu Phe Lys Asn Ala 
                 245                250                255
Met Arg Ala Thr Val Glu Ser His Glu Ser Ser Leu Ile Leu Pro Pro 
             260                265                270
Ile Lys Val Met Val Ala Leu Gly Glu Glu Asp Leu Ser Ile Lys Met 
         275                280                285
Ser Asp Arg Gly Gly Gly Val Pro Leu Arg Lys Ile Glu Arg Leu Phe 
     290                295                300
Ser Tyr Met Tyr Ser Thr Ala Pro Thr Pro Gln Pro Gly Thr Gly Gly 
 305                310                315                320
Thr Pro Leu Ala Gly Phe Gly Tyr Gly Leu Pro Ile Ser Arg Leu Tyr 
                 325                330                335
Ala Lys Tyr Phe Gln Gly Asp Leu Gln Leu Phe Ser Met Glu Gly Phe 
             340                345                350
Gly Thr Asp Ala Val Ile Tyr Leu Lys Ala Leu Ser Thr Asp Ser Val 
         355                360                365
Glu Arg Leu Pro Val Tyr Asn Lys Ser Ala Trp Arg His Tyr Gln Thr 
     370                375                380
Ile Gln Glu Ala Gly Asp Trp Cys Val Pro Ser Thr Glu Pro Lys Asn 
 385                390                395                400
Thr Ser Thr Tyr Arg Val Ser 
                 405



<210> 8081
<211> 2207
<212> DNA
<213> Rattus norvegicus
<308> U10357
<400> 8081

gtctcccgg  tgtgcttgg  cgtgcggag  gccggtgcc  gcacctcca  ctccgggac  60
gcagcggga  ccaagcccg  gccgcaggc  tcgtcgcca  gcgctggtt  cgggcgctg  120
tgaagaatg  gtccctggc  ggggcgccc  agtacatcg  gcacttcag  aagttctcc  180
cgtccccgc  gtccatgaa  cagtttcta  acttcggat  cagcaatgc  tgcgagaaa  240
cttcattca  cttcctccg  caggagctg  ccgtgcgcc  ggccaacat  atgaaagag  300
tcaacctgc  tcctgaccg  gtgctgagc  ccccctcag  gcaactggt  cagagctgg  360
atgtccaga  tctgctgga  atcatggaa  tcctggaca  ggaccccga  gaccaccgg  420
ccctaagcc  gttcactga  gccctggtc  ccatccgga  ccggcacaa  gacgtagtg  480
ccaccatgg  acagggagt  ttggagtac  aggacacct  tggtgatga  ccagtctcc  540
accagaaca  ccagtactt  ttggaccgc  tctacctca  ccgcatctc  atccgcatg  600
tcattaacc  gcacaccct  atctttgat  gcagcacca  cccagccca  cccaaacac  660
ttggcagca  tgatcccaa  tgcagcgtg  ctgatgtgg  gaaagatgc  tatgacatg  720
ctaagctcc  gtgtgacaa  tattacatg  cttcccctg  cctggagat  caggaagtc  780
atgccacca  cgccaccca  cccattcac  tggtctacg  cccctccca  ctctaccac  840
tgctctttg  actcttcaa  aatgccatg  gggccacag  ggaaagcca  gagtccagc  900
tcactctcc  tcccatcaa  atcatggtg  ccctcggtg  agaagatct  tccatcaaa  960
tgagtgacc  aggcggggg  gtccccttg  ggaagatcg  gaggctctt  agctacatg  1020
actctacag  tcctacacc  cagcctggc  ctgggggta  cccgctggc  ggctttggg  1080
atggactcc  catttcccg  ctctacgcc  agtacttcc  gggggactt  cagctcttc  1140
ctatggagg  ctttgggac  gatgctgtc  tctatctga  ggccctgtc  acggactca  1200
tggagcgcc  gcctgtcta  aacaagtct  cctggcgcc  ctaccagac  atccaggag  1260
ccggtgact  gtgcgtgcc  agcacagag  ccaagaaca  atcgacgta  cgggtcagc  1320
aggggcctt  tcttcctgg  acctgggag  atgctgcca  ctctgaatc  agccaccac  1380
gggacttcc  tatctatcc  ctggggtac  ggggtgaaa  tgggtctcc  cgatggcca  1440
atctgtctt  gtagaaatc  cagtggccc  tctgtggcg  tccctaagt  ccaatctgt  1500
tctatggag  aacctaggg  gtttccctg  agcctggtc  ccatggtga  gatgcttga  1560
ggttgggga  ggctctacc  ggtggggtg  ccccagaga  acttctccc  agaccagag  1620
tgtctgttt  ctaccagaa  ccctgggtc  ccctcactg  ctgcatagt  ctggtctcc  1680
acgtggctg  ctcgcttgc  ttatgccca  accctgtac  ggcacattg  gctggtttc  1740
tcgtcagta  taagaaaga  ggagagaga  tggggaaac  ggggccaac  ttgtctctg  1800
tcctgcagc  tctctccat  tccactctg  acactaaag  tgccactgg  aacttgaga  1860
tgggtggcc  ttctcaccc  aggcccacc  agaaggcct  agagtaacc  gtccccaag  1920
cgatcttag  aatgtttct  ccgcttcct  gcctggcat  tcctcacgt  tatacctcc  1980
ctgcccagt  tacgctcac  ctatccctg  ttgagcttt  gaccccaga  ttcctatgc  2040
cactatgtg  gcacagacg  ctcaaaccc  ggatgcccc  tgtacatag  cagttttgt  2100
atctcagat  cctcaccct  gccctccgc  cacaggggt  aaagccgtg  gcccctccc  2160
gtggctggg  tggtgacag  gacatccac  gtaaataga  gaaatga  2207



<210> 8082
<211> 407
<212> PRT
<213> Rattus norvegicus
<308> Q64536
<400> 8082

Met Arg Trp Phe Arg Ala Leu Leu Lys Asn Ala Ser Leu Ala Gly Ala 
  1               5                  10                  15
Pro Lys Tyr Ile Glu His Phe Ser Lys Phe Ser Pro Ser Pro Leu Ser 
             20                  25                  30
Met Lys Gln Phe Leu Asp Phe Gly Ser Ser Asn Ala Cys Glu Lys Thr 
         35                  40                  45
Ser Phe Thr Phe Leu Arg Gln Glu Leu Pro Val Arg Leu Ala Asn Ile 
     50                  55                  60
Met Lys Glu Ile Asn Leu Leu Pro Asp Arg Val Leu Ser Thr Pro Ser 
 65                  70                  75                  80
Val Gln Leu Val Gln Ser Trp Tyr Val Gln Ser Leu Leu Asp Ile Met 
                 85                  90                  95
Glu Phe Leu Asp Lys Asp Pro Glu Asp His Arg Thr Leu Ser Gln Phe 
             100                105                110
Thr Asp Ala Leu Val Thr Ile Arg Asn Arg His Asn Asp Val Val Pro 
         115                120                125
Thr Met Ala Gln Gly Val Leu Glu Tyr Lys Asp Thr Tyr Gly Asp Asp 
     130                135                140
Pro Val Ser Asn Gln Asn Ile Gln Tyr Phe Leu Asp Arg Phe Tyr Leu 
 145                150                155                160
Ser Arg Ile Ser Ile Arg Met Leu Ile Asn Gln His Thr Leu Ile Phe 
                 165                170                175
Asp Gly Ser Thr Asn Pro Ala His Pro Lys His Ile Gly Ser Ile Asp 
             180                185                190
Pro Asn Cys Ser Val Ser Asp Val Val Lys Asp Ala Tyr Asp Met Ala 
         195                200                205
Lys Leu Leu Cys Asp Lys Tyr Tyr Met Ala Ser Pro Asp Leu Glu Ile 
     210                215                220
Gln Glu Val Asn Ala Thr Asn Ala Thr Gln Pro Ile His Met Val Tyr 
 225                230                235                240
Val Pro Ser His Leu Tyr His Met Leu Phe Glu Leu Phe Lys Asn Ala 
                 245                250                255
Met Arg Ala Thr Val Glu Ser His Glu Ser Ser Leu Thr Leu Pro Pro 
             260                265                270
Ile Lys Ile Met Val Ala Leu Gly Glu Glu Asp Leu Ser Ile Lys Met 
         275                280                285
Ser Asp Arg Gly Gly Gly Val Pro Leu Arg Lys Ile Glu Arg Leu Phe 
     290                295                300
Ser Tyr Met Tyr Ser Thr Ala Pro Thr Pro Gln Pro Gly Thr Gly Gly 
 305                310                315                320
Thr Pro Leu Ala Gly Phe Gly Tyr Gly Leu Pro Ile Ser Arg Leu Tyr 
                 325                330                335
Ala Lys Tyr Phe Gln Gly Asp Leu Gln Leu Phe Ser Met Glu Gly Phe 
             340                345                350
Gly Thr Asp Ala Val Ile Tyr Leu Lys Ala Leu Ser Thr Asp Ser Val 
         355                360                365
Glu Arg Leu Pro Val Tyr Asn Lys Ser Ala Trp Arg His Tyr Gln Thr 
     370                375                380
Ile Gln Glu Ala Gly Asp Trp Cys Val Pro Ser Thr Glu Pro Lys Asn 
 385                390                395                400
Thr Ser Thr Tyr Arg Val Ser 
                 405



<210> 8083
<211> 2260
<212> DNA
<213> Homo sapiens
<308> NM_002611
<400> 8083

ggcacgagg  agcgctgcc  gcgcgggga  cacaaccca  gtcgcggcc  ccgcagcca  60
gcgctgggt  tgggcgctg  tgaagaatg  gtccctggc  ggggcgccc  agtacatag  120
gcacttcag  aagttctcc  cgtccccgc  gtccatgaa  cagtttctg  acttcggat  180
cagcaatgc  tgtgagaaa  cctccttca  cttcctcag  caggagctg  ctgtgcgcc  240
ggccaacat  atgaaagag  tcaacctgc  tcccgaccg  gtgctgagc  caccctccg  300
gcagctggt  cagagctgg  atgtccaga  cctcctgga  atcatggag  tcctggaca  360
ggatcccga  gaccatcgc  ccctgagcc  gttcactga  gccctggtc  ccatccgga  420
ccggcacaa  gacgtggtg  ccaccatgg  acaaggcgt  cttgagtac  aggacacct  480
cggcgatga  cccgtctcc  accagaaca  ccagtactt  ctggaccgc  tctacctca  540
ccgcatctc  atccgcatg  tcatcaacc  gcacaccct  atctttgat  gcagcacca  600
cccagccca  cccaaacac  tcggcagca  cgaccccaa  tgcaacgtc  ctgaggtgg  660
caaagatgc  tacgacatg  ctaagctcc  gtgtgacaa  tattacatg  cctcacctg  720
cctggagat  caggagatc  atgcagcca  ctccaaaca  ccgattcac  tggtctacg  780
cccctccca  ctctaccac  tgctctttg  gctcttcaa  aatgccatg  gggcgactg  840
ggaaagcca  gagtccagc  tcattctcc  acccatcaa  gtcatggtg  ccttgggtg  900
ggaagatct  tccatcaag  tgagtgacc  aggtggggg  gttcccttg  ggaagattg  960
gcgactctt  agctacatg  actccacag  acccacccc  cagcctggc  ccgggggaa  1020
gccgctggc  ggctttggt  atgggctcc  catttcccg  ctctacgcc  agtacttcc  1080
gggagacct  cagctcttc  ccatggaag  ctttgggac  gatgctgtc  tctatctca  1140
ggccctgtc  acggactcg  tggagcgcc  gcctgtcta  aacaagtca  cctggcgcc  1200
ctaccagac  atccaggag  ccggcgact  gtgtgtgcc  agcacggag  ccaagaaca  1260
gtccacgta  cgcgtcagc  aagggccgc  gtgcatctg  acctgagag  acggactgc  1320
gcctctggg  ccccccacc  tggtgcccc  caccatcct  ctgggggag  agggggtgg  1380
ttctccctg  tgaccaggt  ctgtctcta  gcaagtcac  gcggtgata  gtctgtgat  1440
gtccctaag  gccagtcca  ctctgtgga  acccctcgg  ggcctccct  tctctgtgg  1500
cgatgcctg  gggttaggg  tgtctccac  ctgatgggg  gtcccagag  cattttccc  1560
tggcagtcc  cctctctga  accagggct  tcacttttc  gccaggggt  ctgggtccc  1620
ctcagcacc  tccacagca  aggccttcc  agtggatgt  ccgttgcct  attccccca  1680
cccacaaag  caccctggc  ttggtctgc  gaagtgtta  gaagagggt  ggtgccctc  1740
agacctggg  actgagtgg  gaaaggagt  acacccgtg  gtggggaat  aggctggtc  1800
tgcagcctc  ccctccgct  agggcttga  ggtcggtgg  ggagggggt  gctctcaca  1860
ggcccaact  taaagtgga  gaaccttgt  agaccgaga  cttgccatc  agccaagct  1920
ctcgaggcc  tgcagtggc  ttggcaatg  ctgtgccac  tcctgagcc  tcccagcat  1980
tcctcacat  ctcatgccc  cccgctcct  cacaagcct  gtccatcct  cctgagctc  2040
agcccccag  ccccactgt  cccagacat  tgtgctcag  gtggctttc  ccctaggac  2100
ttctgtgta  atagttagt  ttataaccc  gaatgcccc  acccttccc  taagcacac  2160
ggggttaaa  ctgtgtgtc  ctcccagtg  ctgtggcag  gacagtgac  cccacaccc  2220
cagtaaaga  gagactgaa  gaaaaaaaa  aaaaaaaaaa  2260



<210> 8084
<211> 407
<212> PRT
<213> Homo sapiens
<308> Q15119
<400> 8084

Met Arg Trp Val Trp Ala Leu Leu Lys Asn Ala Ser Leu Ala Gly Ala 
  1               5                  10                  15
Pro Lys Tyr Ile Glu His Phe Ser Lys Phe Ser Pro Ser Pro Leu Ser 
             20                  25                  30
Met Lys Gln Phe Leu Asp Phe Gly Ser Ser Asn Ala Cys Glu Lys Thr 
         35                  40                  45
Ser Phe Thr Phe Leu Arg Gln Glu Leu Pro Val Arg Leu Ala Asn Ile 
     50                  55                  60
Met Lys Glu Ile Asn Leu Leu Pro Asp Arg Val Leu Ser Thr Pro Ser 
 65                  70                  75                  80
Val Gln Leu Val Gln Ser Trp Tyr Val Gln Ser Leu Leu Asp Ile Met 
                 85                  90                  95
Glu Phe Leu Asp Lys Asp Pro Glu Asp His Arg Thr Leu Ser Gln Phe 
             100                105                110
Thr Asp Ala Leu Val Thr Ile Arg Asn Arg His Asn Asp Val Val Pro 
         115                120                125
Thr Met Ala Gln Gly Val Leu Glu Tyr Lys Asp Thr Tyr Gly Asp Asp 
     130                135                140
Pro Val Ser Asn Gln Asn Ile Gln Tyr Phe Leu Asp Arg Phe Tyr Leu 
 145                150                155                160
Ser Arg Ile Ser Ile Arg Met Leu Ile Asn Gln His Thr Leu Ile Phe 
                 165                170                175
Asp Gly Ser Thr Asn Pro Ala His Pro Lys His Ile Gly Ser Ile Asp 
             180                185                190
Pro Asn Cys Asn Val Ser Glu Val Val Lys Asp Ala Tyr Asp Met Ala 
         195                200                205
Lys Leu Leu Cys Asp Lys Tyr Tyr Met Ala Ser Pro Asp Leu Glu Ile 
     210                215                220
Gln Glu Ile Asn Ala Ala Asn Ser Lys Gln Pro Ile His Met Val Tyr 
 225                230                235                240
Val Pro Ser His Leu Tyr His Met Leu Phe Glu Leu Phe Lys Asn Ala 
                 245                250                255
Met Arg Ala Thr Val Glu Ser His Glu Ser Ser Leu Ile Leu Pro Pro 
             260                265                270
Ile Lys Val Met Val Ala Leu Gly Glu Glu Asp Leu Ser Ile Lys Met 
         275                280                285
Ser Asp Arg Gly Gly Gly Val Pro Leu Arg Lys Ile Glu Arg Leu Phe 
     290                295                300
Ser Tyr Met Tyr Ser Thr Ala Pro Thr Pro Gln Pro Gly Thr Gly Gly 
 305                310                315                320
Thr Pro Leu Ala Gly Phe Gly Tyr Gly Leu Pro Ile Ser Arg Leu Tyr 
                 325                330                335
Ala Lys Tyr Phe Gln Gly Asp Leu Gln Leu Phe Ser Met Glu Gly Phe 
             340                345                350
Gly Thr Asp Ala Val Ile Tyr Leu Lys Ala Leu Ser Thr Asp Ser Val 
         355                360                365
Glu Arg Leu Pro Val Tyr Asn Lys Ser Ala Trp Arg His Tyr Gln Thr 
     370                375                380
Ile Gln Glu Ala Gly Asp Trp Cys Val Pro Ser Thr Glu Pro Lys Asn 
 385                390                395                400
Thr Ser Thr Tyr Arg Val Ser 
                 405



<210> 8085
<211> 2514
<212> DNA
<213> Rattus norvegicus
<308> U10995
<400> 8085

cgccgcctg  gccatttct  attttgcaa  ttggggaag  agaaaaaag  gagagaagg  60
agctcgctc  ccggggggt  gggaggggg  agagagagc  cggcccccc  aggaacgga  120
cgcgggggg  agcgggcga  gggagcagg  gtgttgggg  ggagcctga  agcctgggg  180
ggctgcaaa  agagagaaa  aaaacagca  gaaccacaa  aaaactcca  cagggcggg  240
gggctccgc  gcagcagcg  ggcggccga  gcagtacgg  agcggcggc  gcggcggag  300
cagcggccg  tgtccggct  gggctcggc  cctgcgacc  cggggcgcc  ggcgggccc  360
ccgccccct  cccctcccc  cttcccctt  cccttcccc  cccagcgcg  ccgcgcgcc  420
cgccgccct  ggcgagcag  tcggctccc  ccagcgctc  ccgggccca  agatatggc  480
atggtagtt  gcagctggc  agatccgca  gacgacgtg  ccgggggca  ccccggcgg  540
cccaacccc  cagcgcagg  agcccgcgg  ggcggcggc  gcgagcaac  gcaggcggg  600
tccggcgcg  cgcacacgc  gcagacccc  ggccagccc  gagcgcccg  cacccccgg  660
acggcaggg  acaagggcc  gggcccgcc  ggttcaggc  agagccagc  gcacatcga  720
tgcgtggtg  gcggggaca  gtcgagcgg  aagcactac  gccaattca  ctgcgaggg  780
tgcaaaagt  tcttcaaga  gagcgtccg  aggaactta  cttacacat  ccgtgccaa  840
aggaactgt  ccatcgacc  gcaccaccg  aaccagtgc  aatactgcc  cctcaagaa  900
tgcctcaaa  tgggcatga  gcgggaagc  gttcagcga  gaagaatgc  tccaaccca  960
cccaatcca  gccagtacg  actcacaaa  ggggatccc  tcaatggcc  ctgctacct  1020
tccggctac  tctccctgc  gctgcgagc  gagccctac  ccacgtcgc  ttatggcag  1080
cagtgcatg  agcccaaca  catcatggg  atcgagaac  tctgcgagc  ggcagcccg  1140
ctcctcttc  gcgccgtcg  gtgggcccg  aacatcccg  tcttcccgg  tctgcagat  1200
accgaccag  tgtccctcc  acgcctcac  tggagcgag  tgttcgtgc  caacgcggc  1260
cagtgctcc  tgcccctgc  cgtggccgt  ctggcagca  ccggcctac  cgcctcgcc  1320
atgtccgcg  accgggtcg  ggccttcat  gaccacatc  gcatctttc  ggaacaggt  1380
gagaagctc  aggcgctgc  cgtcgactc  gccgagtac  gctgcctca  agccatcgt  1440
ctgttcacg  cagatgctt  tggcctgtc  gatgctgca  acatcgaaa  cctgcagga  1500
aaatcgcag  gtgcactgg  ggaatacgt  aggagccag  accccaacc  gcccagccg  1560
tttggcaaa  tgctgctgc  attgccctc  cttcgcaca  tgtcctctt  tgtcataga  1620
cagctcttc  tcgtccgtt  ggtaggtaa  acccccatc  aaactctca  ccgagacat  1680
ttgttgtca  ggagcagtt  caactggcc  tacatgtcc  tccagtgct  ctagacctt  1740
ggtgtttcc  acctgcccc  gcaccccct  acgccctag  gactaagcg  actcaccct  1800
taccaagga  tcaaaagcc  ttggggatg  tggtatcag  gcaggcagg  cggagggga  1860
gagggccga  gagaggccc  ctctgcaga  atacaatcc  agctacaaa  catgggaaa  1920
agagactct  ttaggatca  atctgtgag  acgttggcg  ggaaaaaca  aacaaacaa  1980
aaaaagaac  ttgtgtctg  ctggtgaaa  aaagaaaaa  aaattggaa  agaggacca  2040
gagaatttt  ataaaacag  aggaaacta  tggaccttc  aggatttat  gtggacgga  2100
gtggatata  tctgtacag  aacaacaca  atggaagtg  actgaagcc  atgtagaaa  2160
acacacaca  tgaacattg  tattcattt  gtaaaatac  agtctttat  ttgcatttt  2220
cgtaaaatt  aaacatcgt  tgcgcataa  caaaaatga  caagaatta  gcggaaata  2280
cattttcca  ataattata  aatataaat  acattttcc  aataattat  aaatatttg  2340
cctgtgtct  tgtatctat  tctgttttg  atttttttc  ggttccaaa  cagatttcc  2400
gtgattcta  actaataat  tttgatata  ccctttgct  cttataatg  gtgcgatat  2460
tgttgtcga  gctgttctt  aagaattaa  attgaagtg  aaatttaaa  aaaa  2514



<210> 8086
<211> 419
<212> PRT
<213> Rattus norvegicus
<308> AAA83437
<400> 8086

Met Ala Met Val Val Ser Ser Trp Arg Asp Pro Gln Asp Asp Val Ala 
  1               5                  10                  15
Gly Gly Asn Pro Gly Gly Pro Asn Pro Ala Ala Gln Ala Ala Arg Gly 
             20                  25                  30
Gly Gly Gly Gly Glu Gln Gln Gln Ala Gly Ser Gly Ala Pro His Thr 
         35                  40                  45
Pro Gln Thr Pro Gly Gln Pro Gly Ala Pro Ala Thr Pro Gly Thr Ala 
     50                  55                  60
Gly Asp Lys Gly Gln Gly Pro Pro Gly Ser Gly Gln Ser Gln Gln His 
 65                  70                  75                  80
Ile Glu Cys Val Val Cys Gly Asp Lys Ser Ser Gly Lys His Tyr Gly 
                 85                  90                  95
Gln Phe Thr Cys Glu Gly Cys Lys Ser Phe Phe Lys Arg Ser Val Arg 
             100                105                110
Arg Asn Leu Thr Tyr Thr Cys Arg Ala Asn Arg Asn Cys Pro Ile Asp 
         115                120                125
Gln His His Arg Asn Gln Cys Gln Tyr Cys Arg Leu Lys Lys Cys Leu 
     130                135                140
Lys Val Gly Met Arg Arg Glu Ala Val Gln Arg Gly Arg Met Pro Pro 
 145                150                155                160
Thr Gln Pro Asn Pro Gly Gln Tyr Ala Leu Thr Asn Gly Asp Pro Leu 
                 165                170                175
Asn Gly His Cys Tyr Leu Ser Gly Tyr Ile Ser Leu Leu Leu Arg Ala 
             180                185                190
Glu Pro Tyr Pro Thr Ser Arg Tyr Gly Ser Gln Cys Met Gln Pro Asn 
         195                200                205
Asn Ile Met Gly Ile Glu Asn Ile Cys Glu Leu Ala Ala Arg Leu Leu 
     210                215                220
Phe Ser Ala Val Glu Trp Ala Arg Asn Ile Pro Phe Phe Pro Asp Leu 
 225                230                235                240
Gln Ile Thr Asp Gln Val Ser Leu Leu Arg Leu Thr Trp Ser Glu Leu 
                 245                250                255
Phe Val Leu Asn Ala Ala Gln Cys Ser Met Pro Leu His Val Ala Val 
             260                265                270
Leu Ala Ala Ala Gly Leu His Ala Ser Pro Met Ser Ala Asp Arg Val 
         275                280                285
Val Ala Phe Met Asp His Ile Arg Ile Phe Gln Glu Gln Val Glu Lys 
     290                295                300
Leu Lys Ala Leu His Val Asp Ser Ala Glu Tyr Ser Cys Leu Lys Ala 
 305                310                315                320
Ile Val Leu Phe Thr Ser Asp Ala Cys Gly Leu Ser Asp Ala Ala His 
                 325                330                335
Ile Glu Ser Leu Gln Glu Lys Ser Gln Cys Ala Leu Glu Glu Tyr Val 
             340                345                350
Arg Ser Gln Tyr Pro Asn Gln Pro Ser Arg Phe Gly Lys Leu Leu Leu 
         355                360                365
Arg Leu Pro Ser Leu Arg Thr Val Ser Ser Ser Val Ile Glu Gln Leu 
     370                375                380
Phe Phe Val Arg Leu Val Gly Lys Thr Pro Ile Glu Thr Leu Ile Arg 
 385                390                395                400
Asp Met Leu Leu Ser Gly Ser Ser Phe Asn Trp Pro Tyr Met Ser Ile 
                 405                410                415
Gln Cys Ser 
             420



<210> 8087
<211> 784
<212> DNA
<213> Homo sapiens
<308> BG701915
<400> 8087

agcggagtg  cgccggggg  ggaaggcag  cgggagaag  aaagctggg  cgggccggg  60
ccacaggag  cccagcccc  cacagcaac  acccgggcg  gaaagaaag  aagagccag  120
gaggcgggc  aagcgcggg  agagaagca  agaagaaat  ttcaccttc  cgcctcatg  180
ccactttga  gcacttctt  aggcggcag  attggcact  gttgcggtg  tgctggtcg  240
tgggacagt  cctgttggc  cggcatgtg  aagttaagt  cctgcggac  ctcctcttg  300
agaaacttt  gcagccctc  cagcaggta  atgaaactc  agagaaaag  tgtggataa  360
tgaaactag  ccatgatga  cctgttttc  ccgtgacca  aatattaac  aggatgaat  420
gcggtggca  tgggcctgc  tcacaggtt  cagcagatg  tctcaatat  tctattaaa  480
tttccttat  tccatatgc  agaggagcc  cagagctgc  tccttatgg  agctaccat  540
ccgtgatgt  agctgccat  cactgggga  cttggcaat  gaattggct  gatcaggaa  600
cctatgtca  ctatggaac  acaacttgc  gctcatctc  attgatgtt  tttcttcca  660
tgacatctt  aacccctca  tcatccatg  ggcttggaa  caacttctt  caaaactcc  720
gctcatgtg  tattttgat  tccttttat  aaacatgga  gtttaatag  tcttacatg  780
gaaa  784



<210> 8088
<211> 423
<212> PRT
<213> Homo sapiens
<308> NP_005645
<400> 8088

Met Ala Met Val Val Ser Ser Trp Arg Asp Pro Gln Asp Asp Val Ala 
  1               5                  10                  15
Gly Gly Asn Pro Gly Gly Pro Asn Pro Ala Ala Gln Ala Ala Arg Gly 
             20                  25                  30
Gly Gly Gly Gly Ala Gly Glu Gln Gln Gln Gln Ala Gly Ser Gly Ala 
         35                  40                  45
Pro His Thr Pro Gln Thr Pro Gly Gln Pro Gly Ala Pro Ala Thr Pro 
     50                  55                  60
Gly Thr Ala Gly Asp Lys Gly Gln Gly Pro Pro Gly Ser Gly Gln Ser 
 65                  70                  75                  80
Gln Gln His Ile Glu Cys Val Val Cys Gly Asp Lys Ser Ser Gly Lys 
                 85                  90                  95
His Tyr Gly Gln Phe Thr Cys Glu Gly Cys Lys Ser Phe Phe Lys Arg 
             100                105                110
Ser Val Arg Arg Asn Leu Thr Tyr Thr Cys Arg Ala Asn Arg Asn Cys 
         115                120                125
Pro Ile Asp Gln His His Arg Asn Gln Cys Gln Tyr Cys Arg Leu Lys 
     130                135                140
Lys Cys Leu Lys Val Gly Met Arg Arg Glu Ala Val Gln Arg Gly Arg 
 145                150                155                160
Met Pro Pro Thr Gln Pro Asn Pro Gly Gln Tyr Ala Leu Thr Asn Gly 
                 165                170                175
Asp Pro Leu Asn Gly His Cys Tyr Leu Ser Gly Tyr Ile Ser Leu Leu 
             180                185                190
Leu Arg Ala Glu Pro Tyr Pro Thr Ser Arg Tyr Gly Ser Gln Cys Met 
         195                200                205
Gln Pro Asn Asn Ile Met Gly Ile Glu Asn Ile Cys Glu Leu Ala Ala 
     210                215                220
Arg Leu Leu Phe Ser Ala Val Glu Trp Ala Arg Asn Ile Pro Phe Phe 
 225                230                235                240
Pro Asp Leu Gln Ile Thr Asp Gln Val Ser Leu Leu Arg Leu Thr Trp 
                 245                250                255
Ser Glu Leu Phe Val Leu Asn Ala Ala Gln Cys Ser Met Pro Leu His 
             260                265                270
Val Ala Pro Leu Leu Ala Ala Ala Gly Leu His Ala Ser Pro Met Ser 
         275                280                285
Ala Asp Arg Val Val Ala Phe Met Asp His Ile Arg Ile Phe Gln Glu 
     290                295                300
Gln Val Glu Lys Leu Lys Ala Leu His Val Asp Ser Ala Glu Tyr Ser 
 305                310                315                320
Cys Leu Lys Ala Ile Val Leu Phe Thr Ser Asp Ala Cys Gly Leu Ser 
                 325                330                335
Asp Ala Ala His Ile Glu Ser Leu Gln Glu Lys Ser Gln Cys Ala Leu 
             340                345                350
Glu Glu Tyr Val Arg Ser Gln Tyr Pro Asn Gln Pro Ser Arg Phe Gly 
         355                360                365
Lys Leu Leu Leu Arg Leu Pro Ser Leu Arg Thr Val Ser Ser Ser Val 
     370                375                380
Ile Glu Gln Leu Phe Phe Val Arg Leu Val Gly Lys Thr Pro Ile Glu 
 385                390                395                400
Thr Leu Ile Arg Asp Met Leu Leu Ser Gly Ser Ser Phe Asn Trp Pro 
                 405                410                415
Tyr Met Ser Ile Gln Cys Ser 
             420



<210> 8089
<211> 2514
<212> DNA
<213> Rattus norvegicus
<308> U10995
<400> 8089

cgccgcctg  gccatttct  attttgcaa  ttggggaag  agaaaaaag  gagagaagg  60
agctcgctc  ccggggggt  gggaggggg  agagagagc  cggcccccc  aggaacgga  120
cgcgggggg  agcgggcga  gggagcagg  gtgttgggg  ggagcctga  agcctgggg  180
ggctgcaaa  agagagaaa  aaaacagca  gaaccacaa  aaaactcca  cagggcggg  240
gggctccgc  gcagcagcg  ggcggccga  gcagtacgg  agcggcggc  gcggcggag  300
cagcggccg  tgtccggct  gggctcggc  cctgcgacc  cggggcgcc  ggcgggccc  360
ccgccccct  cccctcccc  cttcccctt  cccttcccc  cccagcgcg  ccgcgcgcc  420
cgccgccct  ggcgagcag  tcggctccc  ccagcgctc  ccgggccca  agatatggc  480
atggtagtt  gcagctggc  agatccgca  gacgacgtg  ccgggggca  ccccggcgg  540
cccaacccc  cagcgcagg  agcccgcgg  ggcggcggc  gcgagcaac  gcaggcggg  600
tccggcgcg  cgcacacgc  gcagacccc  ggccagccc  gagcgcccg  cacccccgg  660
acggcaggg  acaagggcc  gggcccgcc  ggttcaggc  agagccagc  gcacatcga  720
tgcgtggtg  gcggggaca  gtcgagcgg  aagcactac  gccaattca  ctgcgaggg  780
tgcaaaagt  tcttcaaga  gagcgtccg  aggaactta  cttacacat  ccgtgccaa  840
aggaactgt  ccatcgacc  gcaccaccg  aaccagtgc  aatactgcc  cctcaagaa  900
tgcctcaaa  tgggcatga  gcgggaagc  gttcagcga  gaagaatgc  tccaaccca  960
cccaatcca  gccagtacg  actcacaaa  ggggatccc  tcaatggcc  ctgctacct  1020
tccggctac  tctccctgc  gctgcgagc  gagccctac  ccacgtcgc  ttatggcag  1080
cagtgcatg  agcccaaca  catcatggg  atcgagaac  tctgcgagc  ggcagcccg  1140
ctcctcttc  gcgccgtcg  gtgggcccg  aacatcccg  tcttcccgg  tctgcagat  1200
accgaccag  tgtccctcc  acgcctcac  tggagcgag  tgttcgtgc  caacgcggc  1260
cagtgctcc  tgcccctgc  cgtggccgt  ctggcagca  ccggcctac  cgcctcgcc  1320
atgtccgcg  accgggtcg  ggccttcat  gaccacatc  gcatctttc  ggaacaggt  1380
gagaagctc  aggcgctgc  cgtcgactc  gccgagtac  gctgcctca  agccatcgt  1440
ctgttcacg  cagatgctt  tggcctgtc  gatgctgca  acatcgaaa  cctgcagga  1500
aaatcgcag  gtgcactgg  ggaatacgt  aggagccag  accccaacc  gcccagccg  1560
tttggcaaa  tgctgctgc  attgccctc  cttcgcaca  tgtcctctt  tgtcataga  1620
cagctcttc  tcgtccgtt  ggtaggtaa  acccccatc  aaactctca  ccgagacat  1680
ttgttgtca  ggagcagtt  caactggcc  tacatgtcc  tccagtgct  ctagacctt  1740
ggtgtttcc  acctgcccc  gcaccccct  acgccctag  gactaagcg  actcaccct  1800
taccaagga  tcaaaagcc  ttggggatg  tggtatcag  gcaggcagg  cggagggga  1860
gagggccga  gagaggccc  ctctgcaga  atacaatcc  agctacaaa  catgggaaa  1920
agagactct  ttaggatca  atctgtgag  acgttggcg  ggaaaaaca  aacaaacaa  1980
aaaaagaac  ttgtgtctg  ctggtgaaa  aaagaaaaa  aaattggaa  agaggacca  2040
gagaatttt  ataaaacag  aggaaacta  tggaccttc  aggatttat  gtggacgga  2100
gtggatata  tctgtacag  aacaacaca  atggaagtg  actgaagcc  atgtagaaa  2160
acacacaca  tgaacattg  tattcattt  gtaaaatac  agtctttat  ttgcatttt  2220
cgtaaaatt  aaacatcgt  tgcgcataa  caaaaatga  caagaatta  gcggaaata  2280
cattttcca  ataattata  aatataaat  acattttcc  aataattat  aaatatttg  2340
cctgtgtct  tgtatctat  tctgttttg  atttttttc  ggttccaaa  cagatttcc  2400
gtgattcta  actaataat  tttgatata  ccctttgct  cttataatg  gtgcgatat  2460
tgttgtcga  gctgttctt  aagaattaa  attgaagtg  aaatttaaa  aaaa  2514



<210> 8090
<211> 419
<212> PRT
<213> Rattus norvegicus
<308> AAA83437
<400> 8090

Met Ala Met Val Val Ser Ser Trp Arg Asp Pro Gln Asp Asp Val Ala 
  1               5                  10                  15
Gly Gly Asn Pro Gly Gly Pro Asn Pro Ala Ala Gln Ala Ala Arg Gly 
             20                  25                  30
Gly Gly Gly Gly Glu Gln Gln Gln Ala Gly Ser Gly Ala Pro His Thr 
         35                  40                  45
Pro Gln Thr Pro Gly Gln Pro Gly Ala Pro Ala Thr Pro Gly Thr Ala 
     50                  55                  60
Gly Asp Lys Gly Gln Gly Pro Pro Gly Ser Gly Gln Ser Gln Gln His 
 65                  70                  75                  80
Ile Glu Cys Val Val Cys Gly Asp Lys Ser Ser Gly Lys His Tyr Gly 
                 85                  90                  95
Gln Phe Thr Cys Glu Gly Cys Lys Ser Phe Phe Lys Arg Ser Val Arg 
             100                105                110
Arg Asn Leu Thr Tyr Thr Cys Arg Ala Asn Arg Asn Cys Pro Ile Asp 
         115                120                125
Gln His His Arg Asn Gln Cys Gln Tyr Cys Arg Leu Lys Lys Cys Leu 
     130                135                140
Lys Val Gly Met Arg Arg Glu Ala Val Gln Arg Gly Arg Met Pro Pro 
 145                150                155                160
Thr Gln Pro Asn Pro Gly Gln Tyr Ala Leu Thr Asn Gly Asp Pro Leu 
                 165                170                175
Asn Gly His Cys Tyr Leu Ser Gly Tyr Ile Ser Leu Leu Leu Arg Ala 
             180                185                190
Glu Pro Tyr Pro Thr Ser Arg Tyr Gly Ser Gln Cys Met Gln Pro Asn 
         195                200                205
Asn Ile Met Gly Ile Glu Asn Ile Cys Glu Leu Ala Ala Arg Leu Leu 
     210                215                220
Phe Ser Ala Val Glu Trp Ala Arg Asn Ile Pro Phe Phe Pro Asp Leu 
 225                230                235                240
Gln Ile Thr Asp Gln Val Ser Leu Leu Arg Leu Thr Trp Ser Glu Leu 
                 245                250                255
Phe Val Leu Asn Ala Ala Gln Cys Ser Met Pro Leu His Val Ala Val 
             260                265                270
Leu Ala Ala Ala Gly Leu His Ala Ser Pro Met Ser Ala Asp Arg Val 
         275                280                285
Val Ala Phe Met Asp His Ile Arg Ile Phe Gln Glu Gln Val Glu Lys 
     290                295                300
Leu Lys Ala Leu His Val Asp Ser Ala Glu Tyr Ser Cys Leu Lys Ala 
 305                310                315                320
Ile Val Leu Phe Thr Ser Asp Ala Cys Gly Leu Ser Asp Ala Ala His 
                 325                330                335
Ile Glu Ser Leu Gln Glu Lys Ser Gln Cys Ala Leu Glu Glu Tyr Val 
             340                345                350
Arg Ser Gln Tyr Pro Asn Gln Pro Ser Arg Phe Gly Lys Leu Leu Leu 
         355                360                365
Arg Leu Pro Ser Leu Arg Thr Val Ser Ser Ser Val Ile Glu Gln Leu 
     370                375                380
Phe Phe Val Arg Leu Val Gly Lys Thr Pro Ile Glu Thr Leu Ile Arg 
 385                390                395                400
Asp Met Leu Leu Ser Gly Ser Ser Phe Asn Trp Pro Tyr Met Ser Ile 
                 405                410                415
Gln Cys Ser 
             420



<210> 8091
<211> 784
<212> DNA
<213> Homo sapiens
<308> BG701915
<400> 8091

agcggagtg  cgccggggg  ggaaggcag  cgggagaag  aaagctggg  cgggccggg  60
ccacaggag  cccagcccc  cacagcaac  acccgggcg  gaaagaaag  aagagccag  120
gaggcgggc  aagcgcggg  agagaagca  agaagaaat  ttcaccttc  cgcctcatg  180
ccactttga  gcacttctt  aggcggcag  attggcact  gttgcggtg  tgctggtcg  240
tgggacagt  cctgttggc  cggcatgtg  aagttaagt  cctgcggac  ctcctcttg  300
agaaacttt  gcagccctc  cagcaggta  atgaaactc  agagaaaag  tgtggataa  360
tgaaactag  ccatgatga  cctgttttc  ccgtgacca  aatattaac  aggatgaat  420
gcggtggca  tgggcctgc  tcacaggtt  cagcagatg  tctcaatat  tctattaaa  480
tttccttat  tccatatgc  agaggagcc  cagagctgc  tccttatgg  agctaccat  540
ccgtgatgt  agctgccat  cactgggga  cttggcaat  gaattggct  gatcaggaa  600
cctatgtca  ctatggaac  acaacttgc  gctcatctc  attgatgtt  tttcttcca  660
tgacatctt  aacccctca  tcatccatg  ggcttggaa  caacttctt  caaaactcc  720
gctcatgtg  tattttgat  tccttttat  aaacatgga  gtttaatag  tcttacatg  780
gaaa  784



<210> 8092
<211> 423
<212> PRT
<213> Homo sapiens
<308> NP_005645
<400> 8092

Met Ala Met Val Val Ser Ser Trp Arg Asp Pro Gln Asp Asp Val Ala 
  1               5                  10                  15
Gly Gly Asn Pro Gly Gly Pro Asn Pro Ala Ala Gln Ala Ala Arg Gly 
             20                  25                  30
Gly Gly Gly Gly Ala Gly Glu Gln Gln Gln Gln Ala Gly Ser Gly Ala 
         35                  40                  45
Pro His Thr Pro Gln Thr Pro Gly Gln Pro Gly Ala Pro Ala Thr Pro 
     50                  55                  60
Gly Thr Ala Gly Asp Lys Gly Gln Gly Pro Pro Gly Ser Gly Gln Ser 
 65                  70                  75                  80
Gln Gln His Ile Glu Cys Val Val Cys Gly Asp Lys Ser Ser Gly Lys 
                 85                  90                  95
His Tyr Gly Gln Phe Thr Cys Glu Gly Cys Lys Ser Phe Phe Lys Arg 
             100                105                110
Ser Val Arg Arg Asn Leu Thr Tyr Thr Cys Arg Ala Asn Arg Asn Cys 
         115                120                125
Pro Ile Asp Gln His His Arg Asn Gln Cys Gln Tyr Cys Arg Leu Lys 
     130                135                140
Lys Cys Leu Lys Val Gly Met Arg Arg Glu Ala Val Gln Arg Gly Arg 
 145                150                155                160
Met Pro Pro Thr Gln Pro Asn Pro Gly Gln Tyr Ala Leu Thr Asn Gly 
                 165                170                175
Asp Pro Leu Asn Gly His Cys Tyr Leu Ser Gly Tyr Ile Ser Leu Leu 
             180                185                190
Leu Arg Ala Glu Pro Tyr Pro Thr Ser Arg Tyr Gly Ser Gln Cys Met 
         195                200                205
Gln Pro Asn Asn Ile Met Gly Ile Glu Asn Ile Cys Glu Leu Ala Ala 
     210                215                220
Arg Leu Leu Phe Ser Ala Val Glu Trp Ala Arg Asn Ile Pro Phe Phe 
 225                230                235                240
Pro Asp Leu Gln Ile Thr Asp Gln Val Ser Leu Leu Arg Leu Thr Trp 
                 245                250                255
Ser Glu Leu Phe Val Leu Asn Ala Ala Gln Cys Ser Met Pro Leu His 
             260                265                270
Val Ala Pro Leu Leu Ala Ala Ala Gly Leu His Ala Ser Pro Met Ser 
         275                280                285
Ala Asp Arg Val Val Ala Phe Met Asp His Ile Arg Ile Phe Gln Glu 
     290                295                300
Gln Val Glu Lys Leu Lys Ala Leu His Val Asp Ser Ala Glu Tyr Ser 
 305                310                315                320
Cys Leu Lys Ala Ile Val Leu Phe Thr Ser Asp Ala Cys Gly Leu Ser 
                 325                330                335
Asp Ala Ala His Ile Glu Ser Leu Gln Glu Lys Ser Gln Cys Ala Leu 
             340                345                350
Glu Glu Tyr Val Arg Ser Gln Tyr Pro Asn Gln Pro Ser Arg Phe Gly 
         355                360                365
Lys Leu Leu Leu Arg Leu Pro Ser Leu Arg Thr Val Ser Ser Ser Val 
     370                375                380
Ile Glu Gln Leu Phe Phe Val Arg Leu Val Gly Lys Thr Pro Ile Glu 
 385                390                395                400
Thr Leu Ile Arg Asp Met Leu Leu Ser Gly Ser Ser Phe Asn Trp Pro 
                 405                410                415
Tyr Met Ser Ile Gln Cys Ser 
             420



<210> 8093
<211> 147
<212> DNA
<213> Rattus norvegicus
<308> U11071
<400> 8093

ttttggatc  gagttacat  ccctagaat  cttgttaaa  actggggca  gggggggtt  60
gggatttag  tcagtggta  agcgcttgc  taggaaggc  aggccctgg  aacagtccc  120
agctccgaa  aaaagaagg  aaaaaaa  147



<210> 8094
<211> 5259
<212> DNA
<213> Rattus norvegicus
<308> U11419
<400> 8094

gctgaagac  ccttaaata  atatatata  atatatatt  gggctacta  cctcacatg  60
acatgggat  atgactctg  attctgcat  gtgagctgc  ctccacacc  tgagatccc  120
tcttacatt  cattttttc  tttgaattt  catctcgtc  agacacaag  ttaaaacca  180
atttacact  cactggatt  taaattttc  tccgttcct  tatcctccg  ctttcttat  240
tggatatgc  agcgagaag  ggaccctgg  tattcccaa  atgctctct  ccttaatct  300
tccgcctag  ggtttggcg  ctacaaacc  agagagccg  ctagctgaa  atgaagccc  360
gcgcagagt  ctgttcccc  aagttctgg  tggtgttgg  cgtcttggc  gtatcaggc  420
gcaaagctc  ttcccaaaa  agccccccc  gcatcggca  cgctgtcat  ctcgtgggc  480
cttcagacg  agtggccat  aaagacgcc  acgagaaag  tgacttcca  catctctca  540
tagttcccc  ggtggagct  gtagccatg  acgaaactg  cccaaagag  atcatcacc  600
gtatctgcg  tcttatgtc  gaccggaag  tccaggggg  ggtgttcgc  gatgacacc  660
accaagaag  catcgctca  atcctcgac  tcatttctg  tcagactct  acccccatc  720
tgggcatcc  tgggggctc  tctatgata  tggcggata  ggatgagtc  tccatgttc  780
tccagtttg  cccgtctat  gaacagcaa  cttccgtca  gctcaacat  atggaagaa  840
atgactggt  catcttttc  atcgtcacc  cctacttcc  tggctacca  gactttgtg  900
acaagatcc  cagtaccat  gagaacagc  tcgtgggct  ggagctcga  gaagtcctc  960
tgctagaca  gtctctgga  gatggcgac  ctaagattc  gaatcagct  aagaagctc  1020
aaagcccca  cattctcct  tattgcacg  aggaggaag  cacctacat  tttgaagta  1080
ctaactcag  tgggctgac  ggctacggc  acacgtgga  tgtgccgag  ctggtggcc  1140
gggatacgg  cacggtgcc  tcagagttc  ccacggggc  tatctctgt  tcttatgat  1200
aatgggact  tggccttcc  gccagagtg  gagatggaa  tgccatcat  accactgct  1260
cctcggaca  gctgtccga  cacagtttc  tccctgagc  caagagcag  tgctacaac  1320
cccacgaga  gaggatcta  cagtctaac  tgttgaata  gtatctgat  aatgtcact  1380
ttgaaggga  aaacctgtc  ttcagcgaa  atggctacc  gatgcatcc  aagctggtg  1440
taatccttc  gaacaagga  aggaagtgg  agagggtgg  gaaatggaa  gacaagtcc  1500
tgcagatga  gtattatgt  tggcctcgg  tgtgtcctg  gactgagga  caagaggat  1560
accatctga  cattgtcac  ttggaggag  cgccatttg  cattgtgga  agcgtggac  1620
ctctcagtg  aacctgcat  aggaataca  tcccgtgcc  gaagcgcat  atctctgag  1680
ataaaacag  tgaggaacc  ggctacatc  aaaaatgct  caaggggtt  tgtattgac  1740
tccttaaga  aatttctaa  tctgtgaag  tcacctatg  cctttacct  gtgaccaat  1800
gcaagcacg  gaagaagat  aatgggacc  ggaatggca  gatcggtga  gtggtcatg  1860
agagggcct  catggcagt  ggatcacta  ctatcaatg  agaacggtc  gaggtggtt  1920
acttctctg  acccttcat  gaaactggc  tcagtgtca  ggtatctcg  agcaatggg  1980
ctgtgtcac  ttctgcctt  ttagagcca  tcagcgctg  cgtgtgggt  atgatgttt  2040
tgatgctgc  cattgtttc  gcggtggct  tctttgtct  tgaatactt  agccctgtg  2100
gttacaaca  gtgcctagc  gatggcaga  agccaggag  cccatcttt  accatcggc  2160
aagcaattt  gttactctg  ggtctggtg  ttaacaact  cgtacctgt  cagaaccca  2220
aggggacca  ctccaagat  atggtgtca  tgtgggcct  ctttgctgt  attttcctg  2280
ccagctaca  tgccaactt  gcagccttc  tgatccaag  ggagtatgt  gaccaggtt  2340
ctggcctga  tgacaagaa  ttccagaga  ctaatgact  ctcaccccc  ttccgcttt  2400
ggactgtgc  caatggcag  acagagagg  atatccgta  taactatgc  gaaatgcat  2460
cctacatgg  aaagttcaa  caaaggggt  tagatgatg  attgctctc  ctgaaaaca  2520
ggaagcttg  tgcattcat  tatgatgca  ctgtgctca  ctacatggc  ggaagggac  2580
aaggctgca  actggtgac  attggcagt  gcaaggtct  tgcttctac  ggctatggc  2640
ttgctatcc  aaaggactc  gggtggaag  gccaggtgg  cctggctat  ctgcagctg  2700
ttggagatg  ggagatgga  gaactggaa  ctctctggc  cactggcat  tgccacaat  2760
agaagaatg  ggtgatgag  agccagctg  acatcgaca  tatggcagg  gtcttctat  2820
tgttggggg  agccatggc  ctcagcctc  tcaccttca  ctgtgagca  ctgttctat  2880
ggcagttcc  gcattgctt  atgggtgtc  gttctggca  gcctggcat  gtcttctcc  2940
tcagcagag  tatctacag  tgtatccat  gggtagcca  agaggagcg  caatccgtg  3000
tgaactccc  cactgccac  atgaacaac  cccactcca  catcctacg  ttgctccgc  3060
cggccaaga  catggccaa  ctgtctgga  taaacggct  ccctcagag  gccctggac  3120
tcatccgcc  agagtcctc  gtctacgac  tctctgagc  tcgtcgcag  ttcacgcat  3180
cagactgca  gtcttacaa  aacccaccc  gtgaggaaa  cctgttcag  gactacatt  3240
gcgaggtag  gagaacatt  ggtaacctg  agctgaagg  cagcaatgt  taccaagac  3300
actatcacc  tcaccaccg  ccacacagc  tcggcagca  cagctccat  gatgggctc  3360
atgactgtg  caacccacc  ttcaccacc  agcccaggt  aatcagcaa  aaacccctg  3420
acatcggcc  gccctcctc  aaacatagc  agctcagcg  cctgtatgg  aagttctct  3480
tcaagagtg  ccgctacag  ggccacgac  acttgattc  atcggatgt  tccgacatc  3540
ccacgcaca  tgtcaccta  gggaacatc  agggcaacg  agccaagag  aggaaacag  3600
agtataagg  cagtctaaa  aagcggcca  cctcggcca  atcgaggag  gagtttgat  3660
aaatcgagc  ggcctaccg  cgccgacca  cccgctccc  ggaccacaa  cgctacttc  3720
gggacaaag  agggctccg  gacttctac  tggaccagt  ccgaacaaa  gagaactcg  3780
ctcactggg  gcacgtgga  ttgactgac  tttacaaag  acgcagtga  gacttcaag  3840
gagattcgg  cagtggagg  gggccctgt  ccaacaggt  tcacctcaa  cacggaacg  3900
gcgagaagc  cggagtggt  ggcggggtg  ctgctcctt  ggagaagaa  ctgaccaat  3960
tggattggg  ggaccggtc  gggggcaac  tctgccgca  ctgtccttc  aagctgcac  4020
attactcct  gacggtggc  gggcagaac  cgggccggc  ggcctgcat  agatgtgag  4080
cctgtaaga  ggctggtaa  ctgtacgac  tcagcaagg  caactccct  caggaactg  4140
accagccgg  tgcccccgt  gctgtgaca  ccaacgcct  cagcaccaa  taccctcaa  4200
gcccgacta  ttccaaggc  cagaagaag  atcggaaca  actgcgccg  cagcattcc  4260
acgacacct  cgtggacct  cagaaggag  aggccgcct  ggccccacg  agcgtgagc  4320
tgaaagaca  gggccgatt  atggatggg  gcccctacg  ccatatgtt  gagatgcca  4380
ctggtgaga  ctcctttgc  aacaagtcc  cagtgccca  tgccggaca  caccacaac  4440
accccggca  cggctacat  ctcagcaag  cgctctacc  tgaccgggt  acgcaaaac  4500
ctttcatcc  cacttttgg  gatgaccag  gcttgcttc  cggcagcaa  tcctacttc  4560
tcaggcagc  cacggtggc  ggggcgtca  aaacaaggc  ggacttccg  gcccttgtc  4620
ccaataagc  agtggtgtc  gcccttcat  gggctgtgc  aggtcgttt  cagaaggac  4680
tttgtatag  gaaccagtc  aacccctgt  tgcctaaca  caaaaaccc  agggctttc  4740
atggctcca  caatggaca  gtttatgag  aactttcta  tattgagtc  gatgtctga  4800
tgagggaag  gagagaggt  aaggtgggt  cgggaggga  agggctgtg  gccgcgtgg  4860
gcgcatgtc  tggaaagag  cgggggtga  cttggctcc  attcgcttt  tcttcttct  4920
ttaatttct  tatgggatc  tggagttct  gttccttac  gaaggcaac  ctcgtggcc  4980
gcaccattt  tcctccctc  cgcagttct  tccttcccg  atctgtcca  cattcctgt  5040
tccatgaga  aatagaacg  ggcctcagt  tgggaggat  gagaggaga  caaagcgct  5100
cctgtgtgc  tctttctag  gcagaaggg  tcttagcag  tcactttga  cgaggcttt  5160
ctgatgctg  tctctttgt  caggtgagg  agcgaaggt  ttctgagga  ggccattga  5220
cctcctgtt  ataagagag  agaggcttt  actgaattc  5259



<210> 8095
<211> 1482
<212> PRT
<213> Rattus norvegicus
<308> Q00960
<400> 8095

Met Lys Pro Ser Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
  1               5                  10                  15
Ala Val Leu Ala Val Ser Gly Ser Lys Ala Arg Ser Gln Lys Ser Pro 
             20                  25                  30
Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
         35                  40                  45
Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
     50                  55                  60
Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
 65                  70                  75                  80
Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                 85                  90                  95
Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
             100                105                110
Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
         115                120                125
Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
     130                135                140
Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
 145                150                155                160
Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                 165                170                175
Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
             180                185                190
Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
         195                200                205
Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
     210                215                220
Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
 225                230                235                240
Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                 245                250                255
Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ser Glu 
             260                265                270
Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
         275                280                285
Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
     290                295                300
Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
 305                310                315                320
Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                 325                330                335
Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
             340                345                350
Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
         355                360                365
Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
     370                375                380
Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
 385                390                395                400
Gln Glu Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                 405                410                415
Val Ile Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn 
             420                425                430
Thr Val Pro Cys Gln Lys Arg Ile Ile Ser Glu Asn Lys Thr Asp Glu 
         435                440                445
Glu Pro Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile 
     450                455                460
Leu Lys Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu 
 465                470                475                480
Val Thr Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly 
                 485                490                495
Met Ile Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser 
             500                505                510
Leu Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro 
         515                520                525
Phe Ile Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr 
     530                535                540
Val Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Asp Val Trp Val 
 545                550                555                560
Met Met Phe Val Met Leu Leu Ile Val Ser Ala Val Ala Val Phe Val 
                 565                570                575
Phe Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Cys Leu Ala Asp Gly 
             580                585                590
Arg Glu Pro Gly Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu 
         595                600                605
Leu Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys 
     610                615                620
Gly Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val 
 625                630                635                640
Ile Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln 
                 645                650                655
Glu Glu Tyr Val Asp Gln Val Ser Gly Leu Ser Asp Lys Lys Phe Gln 
             660                665                670
Arg Pro Asn Asp Phe Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn 
         675                680                685
Gly Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Ala Glu Met His Ala 
     690                695                700
Tyr Met Gly Lys Phe Asn Gln Arg Gly Val Asp Asp Ala Leu Leu Ser 
 705                710                715                720
Leu Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu 
                 725                730                735
Asn Tyr Met Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly 
             740                745                750
Ser Gly Lys Val Phe Ala Ser Thr Gly Tyr Gly Ile Ala Ile Gln Lys 
         755                760                765
Asp Ser Gly Trp Lys Arg Gln Val Asp Leu Ala Ile Leu Gln Leu Phe 
     770                775                780
Gly Asp Gly Glu Met Glu Glu Leu Glu Ala Leu Trp Leu Thr Gly Ile 
 785                790                795                800
Cys His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp 
                 805                810                815
Asn Met Ala Gly Val Phe Tyr Met Leu Gly Ala Ala Met Ala Leu Ser 
             820                825                830
Leu Ile Thr Phe Ile Cys Glu His Leu Phe Tyr Trp Gln Phe Arg His 
         835                840                845
Cys Phe Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile 
     850                855                860
Ser Arg Gly Ile Tyr Ser Cys Ile His Gly Val Ala Ile Glu Glu Arg 
 865                870                875                880
Gln Ser Val Met Asn Ser Pro Thr Ala Thr Met Asn Asn Thr His Ser 
                 885                890                895
Asn Ile Leu Arg Leu Leu Arg Thr Ala Lys Asn Met Ala Asn Leu Ser 
             900                905                910
Gly Val Asn Gly Ser Pro Gln Ser Ala Leu Asp Phe Ile Arg Arg Glu 
         915                920                925
Ser Ser Val Tyr Asp Ile Ser Glu His Arg Arg Ser Phe Thr His Ser 
     930                935                940
Asp Cys Lys Ser Tyr Asn Asn Pro Pro Cys Glu Glu Asn Leu Phe Ser 
 945                950                955                960
Asp Tyr Ile Ser Glu Val Glu Arg Thr Phe Gly Asn Leu Gln Leu Lys 
                 965                970                975
Asp Ser Asn Val Tyr Gln Asp His Tyr His His His His Arg Pro His 
             980                985                990
Ser Ile Gly Ser Thr Ser Ser Ile Asp Gly Leu Tyr Asp Cys Asp Asn 
         995                1000                1005
Pro Pro Phe Thr Thr Gln Pro Arg Ser Ile Ser Lys Lys Pro Leu Asp 
     1010                1015                1020
Ile Gly Leu Pro Ser Ser Lys His Ser Gln Leu Ser Asp Leu Tyr Gly 
 1025                1030                1035                1040
Lys Phe Ser Phe Lys Ser Asp Arg Tyr Ser Gly His Asp Asp Leu Ile 
                 1045                1050                1055
Arg Ser Asp Val Ser Asp Ile Ser Thr His Thr Val Thr Tyr Gly Asn 
             1060                1065                1070
Ile Glu Gly Asn Ala Ala Lys Arg Arg Lys Gln Gln Tyr Lys Asp Ser 
         1075                1080                1085
Leu Lys Lys Arg Pro Ala Ser Ala Lys Ser Arg Arg Glu Phe Asp Glu 
     1090                1095                1100
Ile Glu Leu Ala Tyr Arg Arg Arg Pro Pro Arg Ser Pro Asp His Lys 
 1105                1110                1115                1120
Arg Tyr Phe Arg Asp Lys Glu Gly Leu Arg Asp Phe Tyr Leu Asp Gln 
                 1125                1130                1135
Phe Arg Thr Lys Glu Asn Ser Pro His Trp Glu His Val Asp Leu Thr 
             1140                1145                1150
Asp Ile Tyr Lys Glu Arg Ser Asp Asp Phe Lys Arg Asp Ser Val Ser 
         1155                1160                1165
Gly Gly Gly Pro Cys Thr Asn Arg Ser His Leu Lys His Gly Thr Gly 
     1170                1175                1180
Glu Lys His Gly Val Val Gly Gly Val Pro Ala Pro Trp Glu Lys Asn 
 1185                1190                1195                1200
Leu Thr Asn Val Asp Trp Glu Asp Arg Ser Gly Gly Asn Phe Cys Arg 
                 1205                1210                1215
Ser Cys Pro Ser Lys Leu His Asn Tyr Ser Ser Thr Val Ala Gly Gln 
             1220                1225                1230
Asn Ser Gly Arg Gln Ala Cys Ile Arg Cys Glu Ala Cys Lys Lys Ala 
         1235                1240                1245
Gly Asn Leu Tyr Asp Ile Ser Glu Asp Asn Ser Leu Gln Glu Leu Asp 
     1250                1255                1260
Gln Pro Ala Ala Pro Val Ala Val Thr Ser Asn Ala Ser Ser Thr Lys 
 1265                1270                1275                1280
Tyr Pro Gln Ser Pro Thr Asn Ser Lys Ala Gln Lys Lys Asn Arg Asn 
                 1285                1290                1295
Lys Leu Arg Arg Gln His Ser Tyr Asp Thr Phe Val Asp Leu Gln Lys 
             1300                1305                1310
Glu Glu Ala Ala Leu Ala Pro Arg Ser Val Ser Leu Lys Asp Lys Gly 
         1315                1320                1325
Arg Phe Met Asp Gly Ser Pro Tyr Ala His Met Phe Glu Met Pro Ala 
     1330                1335                1340
Gly Glu Ser Ser Phe Ala Asn Lys Ser Ser Val Pro Thr Ala Gly His 
 1345                1350                1355                1360
His His Asn Asn Pro Gly Ser Gly Tyr Met Leu Ser Lys Ser Leu Tyr 
                 1365                1370                1375
Pro Asp Arg Val Thr Gln Asn Pro Phe Ile Pro Thr Phe Gly Asp Asp 
             1380                1385                1390
Gln Cys Leu Leu His Gly Ser Lys Ser Tyr Phe Phe Arg Gln Pro Thr 
         1395                1400                1405
Val Ala Gly Ala Ser Lys Thr Arg Pro Asp Phe Arg Ala Leu Val Thr 
     1410                1415                1420
Asn Lys Pro Val Val Val Thr Leu His Gly Ala Val Pro Gly Arg Phe 
 1425                1430                1435                1440
Gln Lys Asp Ile Cys Ile Gly Asn Gln Ser Asn Pro Cys Val Pro Asn 
                 1445                1450                1455
Asn Lys Asn Pro Arg Ala Phe Asn Gly Ser Ser Asn Gly His Val Tyr 
             1460                1465                1470
Glu Lys Leu Ser Ser Ile Glu Ser Asp Val 
         1475                1480



<210> 8096
<211> 5969
<212> DNA
<213> Homo sapiens
<308> U11287
<400> 8096

tttgaattt  catctcttc  agacacaag  ttaaaacaa  atttacgct  aattggatt  60
taaattatc  tccgttcat  tatccttcg  ctttcttat  tggatatgc  agcgagaag  120
agggactgg  cattcccaa  atgctcact  ccttaatct  tccgtctag  ggtttggct  180
ctacaaacc  agggagtcg  cgagttgaa  atgaagccc  gagcggagt  ctgttctcc  240
aagttctgg  tggtgttgg  cgtcctggc  gtgtcaggc  gcagagctc  ttctcagaa  300
agccccccc  gcattggca  tgctgtcat  ctcgtgggc  cttccgacg  ggtggccat  360
aaggatgcc  acgagaaag  tgatttcca  catctctcc  tggtacccc  ggtggaact  420
gtagccatg  atgagaccg  cccaaagag  atcatcacc  gcatctgtg  tctcatgtc  480
gaccggaag  tccaggggg  ggtgtttgc  gatgacaca  accaggaag  catcgccca  540
atcctcgat  tcatttcag  acagactct  accccgatc  tgggcatcc  cgggggctc  600
tctatgata  tggcagata  ggatgaatc  tccatgttc  tccagtttg  cccatcaat  660
gaacagcaa  cttccgtaa  gctcaacat  atggaagaa  atgactggt  catcttttc  720
atcgtcacc  cctatttcc  tggctacca  gactttgta  acaagatcc  cagcaccat  780
gagaatagc  ttgtgggct  ggagctaga  gaggtcctc  tactggaca  gtccctgga  840
gatggagat  ctaagatcc  gaatcagct  aagaaactt  aaagcccca  cattcttct  900
tactgtacc  aggaagaag  cacctacat  tttgaagtg  ccaactcag  agggctgac  960
ggctatggc  acacgtgga  cgtgcccag  ctggtggca  gggatacag  cacagtgcc  1020
gcggagttc  ccactgggc  catctctgt  tcatatgat  aatgggact  tggcctccc  1080
gccagagtg  gagatggaa  tgccataat  accactgct  cttctgaca  gctgtctga  1140
cacagcttc  tccctgagc  caaaagcag  tgttacaac  cccacgaga  gagaatcta  1200
cagtccaat  tgctaaata  gtatctgat  aatgtcact  ttgagggga  gaatttgtc  1260
ttcagtgaa  atggctacc  gatgcaccc  aaactggtg  taattcttc  gaacaagga  1320
aggaagtgg  aaagggtgg  gaagtggaa  gacaagtcc  tgcagatga  gtactatgt  1380
tggccccga  tgtgtccag  gactgaaga  caggaggat  accatctga  cattgtgac  1440
ctggaggag  caccatttg  cattgtgga  agtgtggac  ctctgagtg  aacctgcat  1500
aggaacaca  tcccctgcc  aaaacgcat  gtcactgag  ataaaacag  cgaggagcc  1560
ggttacatc  aaaaatgct  caaggggtt  tgtattgac  tccttaaga  aatttctaa  1620
tctgtgaag  tcacctatg  cctttacct  gttaccaat  gcaagcatg  gaagaaaat  1680
aatggaacc  ggaatggta  gattggaga  gtggtcatg  agagggcct  catggcagt  1740
ggctcactc  ccatcaatg  ggaacgatc  gaggtggtc  acttctctg  gcccttcat  1800
gagacaggc  tcagtgtca  ggtgtcacg  agcaatggg  ctgtctcac  ttctgcctt  1860
ttagagcca  tcagcgctg  cgtatgggt  atgatgttt  tgatgctgc  catcgtctc  1920
gccgtggct  tctttgtct  tgagtactt  agccctgtg  gttataaca  gtgcctcgc  1980
gatggcaga  agcctggtg  accctcttt  accatcggc  aagctattt  gttgctctg  2040
ggtctggtg  ttaacaact  cgtacctgt  cagaaccca  aggggacca  ctccaagat  2100
atggtgtca  tgtgggcct  ctttgctgt  atcttcctg  ccagctaca  tgccaactt  2160
gctgccttc  tgatccaag  ggaatatgt  gaccaggtt  ctggcctga  cgacaaaaa  2220
ttccagaga  ctaatgact  ctcaccccc  ttccgcttt  ggaccgtgc  caacggcag  2280
acagagaga  atattcgca  taactatgc  gaaatgcat  cctacatgg  aaagttcaa  2340
cagaggggt  tagatgatg  attgctctc  ctgaaaaca  ggaaactgg  tgccttcat  2400
tatgatgca  cagtgctga  ctatatggc  ggcagagat  aaggctgca  gctggtgac  2460
attggcagt  ggaaggtct  tgcttccac  ggctatggc  ttgccatcc  aaaagattc  2520
gggtggaag  gccaggtgg  ccttgctat  ctgcagctc  ttggagatg  ggagatgga  2580
gaactggaa  ctctctggc  cactggcat  tgtcacaat  agaagaatg  ggtcatgag  2640
agccagctg  acattgaca  catggcagg  gtcttctac  tgttggggg  ggccatggc  2700
ctcagcctc  tcaccttca  ctgcgaaca  cttttctat  ggcagttcc  acattgctt  2760
atgggtgtc  gttctggca  gcctggcat  gtcttctcc  tcagcagag  tatctacag  2820
tgcatccat  gggtggcga  cgaggagcg  cagtctgta  tgaactccc  caccgcaac  2880
atgaacaac  cacactcca  catcctgcg  ctgctgcgc  cggccaaga  catggctaa  2940
ctgtctggt  tgaatggct  accgcagag  cccctggac  tcatccgac  ggagtcatc  3000
gtctatgac  tctcagagc  ccgccgcag  ttcacgcat  ctgactgca  atcctacaa  3060
aacccgccc  gtgaggaga  cctcttcag  gactacatc  gtgaggtag  gagaacgtt  3120
gggaacctg  agctgaagg  cagcaacgt  taccaagat  actaccacc  tcaccaccg  3180
ccccatagt  ttggcagtg  cagctccat  gatgggctc  acgactgtg  caacccacc  3240
ttcaccacc  agtccaggt  catcagcaa  aagcccctg  acatcggcc  cccctcctc  3300
aagcacagc  agctcagtg  cctgtacgg  aaattctcc  tcaagagcg  ccgctacag  3360
ggccacgac  acttgatcc  ctccgatgt  tctgacatc  caacccaca  cgtcaccta  3420
gggaacatc  agggcaatg  cgccaagag  cgtaagcag  aatataagg  cagcctgaa  3480
aagcggcct  cctcggcca  gtcccgcag  gagtttgac  agatcgagc  ggcctaccg  3540
cgccgaccg  cccgctccc  tgaccacaa  cgctacttc  gggacaagg  agggctacg  3600
gacttctac  tggaccagt  ccgaacaaa  gagaactca  cccactggg  gcacgtaga  3660
ctgaccgac  tctacaagg  gcggagtga  gactttaag  gcgactccg  cagcggagg  3720
gggccctgt  ccaacaggt  tcacatcaa  cacgggacg  gcgacaaac  cggcgtggt  3780
agcggggta  ctgcacctt  ggagaagaa  ctgaccaac  tggagtggg  ggaccggtc  3840
gggggcaac  tctgccgca  ctgtccctc  aagctgcac  actactcca  gacggtgac  3900
ggtcagaac  cgggcaggc  ggcgtgcat  cggtgtgag  cttgcaaga  agcaggcaa  3960
ctgtatgac  tcagtgagg  caactccct  caggaactg  accagccgg  tgccccagt  4020
gcggtgacg  caaacgcct  caccactaa  taccctcag  gcccgacta  ttccaaggc  4080
cagaagaag  accggaaca  actgcgccg  cagcactcc  acgacacct  cgtggacct  4140
cagaaggaa  aagccgccc  ggccccgcg  agcgtaagc  tgaaagaca  gggccgatt  4200
atggatggg  gcccctacg  ccacatgtt  gagatgtca  ctggcgaga  cacctttgc  4260
aacaacaag  cctcagtgc  cactgccgg  catcaccac  acaacaacc  cggcggcgg  4320
tacatgctc  gcaagtcgc  ctaccctga  cgggtcacg  aaaaccctt  catccccac  4380
tttggggac  accagtgct  gctccatgg  agcaaatcc  acttcttca  gcagcccac  4440
gtggcgggg  cgtcgaaag  caggccgga  ttccgggcc  ttgtcacca  caagccggt  4500
gtctcggcc  ttcatgggg  cgtgccagc  cgtttccag  aggacatct  tatagggaa  4560
cagtccaac  cctgtgtgc  taacaacaa  aaccccagg  ctttcaatg  ctccagcaa  4620
gggcatgtt  atgagaaac  ttctagtat  gagtctgat  tctgagtga  ggaacagag  4680
ggttaaggt  ggtacggga  ggtaaggct  tgggtcgcg  gatgcgcat  tcacggagg  4740
tgacggggg  gaacttggt  cccatttgc  cctttcttg  tttaattta  ttatgggga  4800
cctggagtt  tggttccta  tgggggcaa  cctggtgac  agcaccatc  ctcctcctt  4860
tcacagttc  ctccttctt  cccccgctg  cagccattc  tgttcccat  agatgatgc  4920
atgggtctc  gcaggggag  gtagagcgg  gaaaggaag  gcagcatgc  ggcttcctc  4980
tggtgtgga  gagctcctt  atatcctct  tgagtgaag  tgggagaac  aaaaagagg  5040
tatgtgagc  caaaggtag  ttttcccaa  ctgatcttt  catttaggt  aggaagcaa  5100
agcatctat  tgagaccat  tagcacact  cttgtgaaa  gaaagaggc  ctggctaaa  5160
tcatgctgc  tagatgaca  ctgtctagg  atcatgtgc  aagcagagg  tgggaggcc  5220
tttgtgttt  tatataagc  aaaaaatgc  tgcttcaac  ccatgagac  cgatagtgg  5280
ggtgaacag  acaaaaggt  attggtggc  gagtggatt  ttgaacaaa  tggaaagta  5340
gttatgata  tgtcccacg  tgccttggg  acaagagca  gtggattgt  cgtgcatgt  5400
tgttcatgc  cacttgcac  catgtgtag  caggtgcct  aagagaagg  aaccttgac  5460
ctttctatt  tttctttca  tatccccaa  cagtgtgat  gtttggctt  tatacagac  5520
gagatggcc  tgtattacc  gaattttgg  tgtgtctcc  ttcatcctt  tggaataag  5580
agaatgaaa  ttcttgata  agaagattc  gtggtctaa  caaaaaaag  cggtgagca  5640
tcctgcaag  gcaaggtac  taaacaagt  ctcagtggt  ggcaactgt  tcaacctgt  5700
tgaaccaag  accttccag  aaggctaaa  ggaaaccga  tttcacagc  atgattctt  5760
tgcccacac  tgggagcaa  agattctac  aagctcttt  gagcattta  actctcgac  5820
ggccaaggt  tggggaaga  cgaagccac  tttgaagaa  taaggagtc  tgtatggta  5880
ggtaagtga  agaggggga  gtttccaat  ctttgatcc  ttcttactt  acctgaagc  5940
agacgagca  gcttcttcc  cccaaaact  5969



<210> 8097
<211> 1484
<212> PRT
<213> Homo sapiens
<308> Q13224
<400> 8097

Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
  1               5                  10                  15
Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
             20                  25                  30
Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
         35                  40                  45
Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
     50                  55                  60
Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
 65                  70                  75                  80
Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                 85                  90                  95
Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
             100                105                110
Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
         115                120                125
Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
     130                135                140
Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
 145                150                155                160
Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                 165                170                175
Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
             180                185                190
Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
         195                200                205
Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
     210                215                220
Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
 225                230                235                240
Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                 245                250                255
Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
             260                265                270
Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
         275                280                285
Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
     290                295                300
Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
 305                310                315                320
Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                 325                330                335
Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
             340                345                350
Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
         355                360                365
Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
     370                375                380
Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
 385                390                395                400
Gln Glu Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                 405                410                415
Val Ile Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn 
             420                425                430
Thr Val Pro Cys Gln Lys Arg Ile Val Thr Glu Asn Lys Thr Asp Glu 
         435                440                445
Glu Pro Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile 
     450                455                460
Leu Lys Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu 
 465                470                475                480
Val Thr Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly 
                 485                490                495
Met Ile Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser 
             500                505                510
Leu Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro 
         515                520                525
Phe Ile Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr 
     530                535                540
Val Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Asp Val Trp Val 
 545                550                555                560
Met Met Phe Val Met Leu Leu Ile Val Ser Ala Val Ala Val Phe Val 
                 565                570                575
Phe Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Cys Leu Ala Asp Gly 
             580                585                590
Arg Glu Pro Gly Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu 
         595                600                605
Leu Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys 
     610                615                620
Gly Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val 
 625                630                635                640
Ile Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln 
                 645                650                655
Glu Glu Tyr Val Asp Gln Val Ser Gly Leu Ser Asp Lys Lys Phe Gln 
             660                665                670
Arg Pro Asn Asp Phe Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn 
         675                680                685
Gly Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Ala Glu Met His Ala 
     690                695                700
Tyr Met Gly Lys Phe Asn Gln Arg Gly Val Asp Asp Ala Leu Leu Ser 
 705                710                715                720
Leu Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu 
                 725                730                735
Asn Tyr Met Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly 
             740                745                750
Ser Gly Lys Val Phe Ala Ser Thr Gly Tyr Gly Ile Ala Ile Gln Lys 
         755                760                765
Asp Ser Gly Trp Lys Arg Gln Val Asp Leu Ala Ile Leu Gln Leu Phe 
     770                775                780
Gly Asp Gly Glu Met Glu Glu Leu Glu Ala Leu Trp Leu Thr Gly Ile 
 785                790                795                800
Cys His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp 
                 805                810                815
Asn Met Ala Gly Val Phe Tyr Met Leu Gly Ala Ala Met Ala Leu Ser 
             820                825                830
Leu Ile Thr Phe Ile Cys Glu His Leu Phe Tyr Trp Gln Phe Arg His 
         835                840                845
Cys Phe Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile 
     850                855                860
Ser Arg Gly Ile Tyr Ser Cys Ile His Gly Val Ala Ile Glu Glu Arg 
 865                870                875                880
Gln Ser Val Met Asn Ser Pro Thr Ala Thr Met Asn Asn Thr His Ser 
                 885                890                895
Asn Ile Leu Arg Leu Leu Arg Thr Ala Lys Asn Met Ala Asn Leu Ser 
             900                905                910
Gly Val Asn Gly Ser Pro Gln Ser Ala Leu Asp Phe Ile Arg Arg Glu 
         915                920                925
Ser Ser Val Tyr Asp Ile Ser Glu His Arg Arg Ser Phe Thr His Ser 
     930                935                940
Asp Cys Lys Ser Tyr Asn Asn Pro Pro Cys Glu Glu Asn Leu Phe Ser 
 945                950                955                960
Asp Tyr Ile Ser Glu Val Glu Arg Thr Phe Gly Asn Leu Gln Leu Lys 
                 965                970                975
Asp Ser Asn Val Tyr Gln Asp His Tyr His His His His Arg Pro His 
             980                985                990
Ser Ile Gly Ser Ala Ser Ser Ile Asp Gly Leu Tyr Asp Cys Asp Asn 
         995                1000                1005
Pro Pro Phe Thr Thr Gln Ser Arg Ser Ile Ser Lys Lys Pro Leu Asp 
     1010                1015                1020
Ile Gly Leu Pro Ser Ser Lys His Ser Gln Leu Ser Asp Leu Tyr Gly 
 1025                1030                1035                1040
Lys Phe Ser Phe Lys Ser Asp Arg Tyr Ser Gly His Asp Asp Leu Ile 
                 1045                1050                1055
Arg Ser Asp Val Ser Asp Ile Ser Thr His Thr Val Thr Tyr Gly Asn 
             1060                1065                1070
Ile Glu Gly Asn Ala Ala Lys Arg Arg Lys Gln Gln Tyr Lys Asp Ser 
         1075                1080                1085
Leu Lys Lys Arg Pro Ala Ser Ala Lys Ser Arg Arg Glu Phe Asp Glu 
     1090                1095                1100
Ile Glu Leu Ala Tyr Arg Arg Arg Pro Pro Arg Ser Pro Asp His Lys 
 1105                1110                1115                1120
Arg Tyr Phe Arg Asp Lys Glu Gly Leu Arg Asp Phe Tyr Leu Asp Gln 
                 1125                1130                1135
Phe Arg Thr Lys Glu Asn Ser Pro His Trp Glu His Val Asp Leu Thr 
             1140                1145                1150
Asp Ile Tyr Lys Glu Arg Ser Asp Asp Phe Lys Arg Asp Ser Val Ser 
         1155                1160                1165
Gly Gly Gly Pro Cys Thr Asn Arg Ser His Ile Lys His Gly Thr Gly 
     1170                1175                1180
Asp Lys His Gly Val Val Ser Gly Val Pro Ala Pro Trp Glu Lys Asn 
 1185                1190                1195                1200
Leu Thr Asn Val Glu Trp Glu Asp Arg Ser Gly Gly Asn Phe Cys Arg 
                 1205                1210                1215
Ser Cys Pro Ser Lys Leu His Asn Tyr Ser Thr Thr Val Thr Gly Gln 
             1220                1225                1230
Asn Ser Gly Arg Gln Ala Cys Ile Arg Cys Glu Ala Cys Lys Lys Ala 
         1235                1240                1245
Gly Asn Leu Tyr Asp Ile Ser Glu Asp Asn Ser Leu Gln Glu Leu Asp 
     1250                1255                1260
Gln Pro Ala Ala Pro Val Ala Val Thr Ser Asn Ala Ser Thr Thr Lys 
 1265                1270                1275                1280
Tyr Pro Gln Ser Pro Thr Asn Ser Lys Ala Gln Lys Lys Asn Arg Asn 
                 1285                1290                1295
Lys Leu Arg Arg Gln His Ser Tyr Asp Thr Phe Val Asp Leu Gln Lys 
             1300                1305                1310
Glu Glu Ala Ala Leu Ala Pro Arg Ser Val Ser Leu Lys Asp Lys Gly 
         1315                1320                1325
Arg Phe Met Asp Gly Ser Pro Tyr Ala His Met Phe Glu Met Ser Ala 
     1330                1335                1340
Gly Glu Ser Thr Phe Ala Asn Asn Lys Ser Ser Val Pro Thr Ala Gly 
 1345                1350                1355                1360
His His His His Asn Asn Pro Gly Gly Gly Tyr Met Leu Ser Lys Ser 
                 1365                1370                1375
Leu Tyr Pro Asp Arg Val Thr Gln Asn Pro Phe Ile Pro Thr Phe Gly 
             1380                1385                1390
Asp Asp Gln Cys Leu Leu His Gly Ser Lys Ser Tyr Phe Phe Arg Gln 
         1395                1400                1405
Pro Thr Val Ala Gly Ala Ser Lys Ala Arg Pro Asp Phe Arg Ala Leu 
     1410                1415                1420
Val Thr Asn Lys Pro Val Val Ser Ala Leu His Gly Ala Val Pro Ala 
 1425                1430                1435                1440
Arg Phe Gln Lys Asp Ile Cys Ile Gly Asn Gln Ser Asn Pro Cys Val 
                 1445                1450                1455
Pro Asn Asn Lys Asn Pro Arg Ala Phe Asn Gly Ser Ser Asn Gly His 
             1460                1465                1470
Val Tyr Glu Lys Leu Ser Ser Ile Glu Ser Asp Val 
         1475                1480



<210> 8098
<211> 8554
<212> DNA
<213> Rattus norvegicus
<308> U11681
<400> 8098

ggcacgagc  gcacgaggc  gtagctgag  cggtggccg  agccgcgcg  acctcaggg  60
aagatgctt  ggacaggcc  tgccacggc  accgccggt  ccgccacat  tagcaacgt  120
agcgttctg  agcagttcg  cagtgggct  aagagccgg  atgaggaga  cagggccaa  180
gcagccaag  agctccagc  ctatgtcac  atggaactt  gagagatga  tcaggagga  240
tctactcgc  tctatgacc  gctgaacca  cacattttt  aactggttt  cagctcaga  300
gccaatgag  ggaagggtg  catcttggc  attgccagc  tcattggag  ggaaggtgg  360
aattccacc  ggattggca  atttgccaa  taccttcgg  acctcctcc  ctcaagtga  420
ccagttgtc  tggagatgg  atccaaggc  attggccgc  ttgcaatgg  aggggacac  480
ttcactgct  agtatgtgg  gtttgaagt  aagcgagcc  tggagtggc  gggtgctga  540
cgaaatgag  gccggagac  tgcagctgt  ctcgttctc  gtgagctgg  catcagcgt  600
cccaccttc  tcttccagc  agttcagcc  ttctttgac  acatttttg  ggctgtgtg  660
gaccccaag  aggccatcc  tgaaggagc  gtggctgcc  ttcgtgcct  tctgattct  720
accacgcag  gggagccga  ggagatgca  aagcctcag  ggtacaggc  cacatttga  780
gaagcagag  aaggttttg  tgagaccct  gccaaagag  agggtatga  ccgagatga  840
cgaatccac  gggccttgc  gatcctcaa  gagctcgtc  gaatcagca  catggaggg  900
gagcgtctg  gagaggaga  ggaggaaat  acccagcag  agctggtac  tgacaagta  960
tgcaaagac  taatgggct  tgggacaaa  cctcggcac  tcactccct  caccagctt  1020
caggctgtg  agccccagc  gtcaaacgc  ttggtggga  tgctggggt  cagctccca  1080
caaggccta  tggggtttg  ggcttcccc  agccctaca  agtccactc  ggtggaaag  1140
cgttgttgc  gagacttga  ggaagagaa  tttgatcag  tgtgccagt  ggtgctgaa  1200
tgtaggagc  gcaagaact  actgatcca  atgacaatc  ttaatctgt  gccccgctt  1260
gctgcattc  gaccgtctg  cttcacaga  acccagtac  tgcaagaca  catgaacca  1320
gtcctgagc  gtgtcaaga  ggaaaagga  cggaccgca  cgttccagg  cctagggct  1380
ctttctgtg  cggtgaggt  cgagtttaa  gtctacctg  cccgagtac  tgacatcat  1440
cgagcagcc  tgcctccaa  ggactttgc  cacaagagg  agaaaactg  gcaggtgga  1500
gccacagtg  tcacgtgca  cagcatgct  gcgcgggcc  tggggccag  catccagca  1560
gacatcaag  agctgctgg  gcccatgtt  gcagtgggc  tgagccctg  gctcactgc  1620
gtgctctat  acctgagcc  gcagattcc  cagctgaag  aagatattc  ggacgggct  1680
ctgaagatg  tgtccctgg  ccttatgca  aaacccctg  ggcacccgg  catgcccaa  1740
ggcctggcc  accagctgg  ctccccagg  cttaccacc  tccctgagg  cagcgacgt  1800
gccagcatc  ctcttgccc  tcgaactct  ggcagcttt  aatttgaag  ccactctct  1860
acccagttc  tccgacact  cgcagatca  ttcctgaac  gtgagcaca  ggagatccg  1920
atggaagca  cccgcacct  ctcccgcct  ctcacaccc  ccatccacc  catcagcgg  1980
catgcccat  tggttagcc  gaccgcagt  caagtggta  cagatgtgc  cagcaagct  2040
cttgtggtc  gcataacag  tcctgatcc  gatatccgc  actgtgtct  ggcctccct  2100
gatgagcgc  tcgatgccc  cttggccca  gcagaaaac  tacaagctc  gtttgtggc  2160
ctgaatgac  aggtctttg  gatccgaga  ctggccatc  gcactgtgg  ccgactcag  2220
agcatgaac  cagcctttg  catgccttt  ctgcgcaag  tgctcatcc  gattttgac  2280
gagctggag  acagtggca  tgggagaat  aaggagcag  gtgcccgca  gctggggca  2340
ctggtctcc  atgcccccc  cctcatccg  ccctatatg  agcctattc  gaaggcttt  2400
attttgaaa  tcaaagatc  agaccctga  ccaaacccg  gcgtgatca  taacgtgtt  2460
gccactata  gagaactgg  tcaggttag  ggcctggag  tgaggaagt  ggtggacga  2520
ctctttgtc  tcatcatgg  catgctgca  gactcctct  ttctggcca  aagacaggt  2580
gctttgtgg  ccctgggac  gttggtggc  agtactggc  acgtggtgg  gccctacag  2640
aagtacccc  ctctgcttg  agtgctgct  aattttctg  agacggagc  gaaccaggg  2700
actcggaga  aggccatcc  agtgttagg  ctcctcggg  ctttggacc  ctacaagca  2760
aaagtgaac  tcggcatga  tgaccagtc  cgagatgct  ctgctgtca  cctgtcaga  2820
tccaagtca  gtcaagatt  ctctgacta  agcaccagt  aaatgctgg  caacatggg  2880
aacctgcca  tggacgagt  ctaccccgc  gtgtccatg  tggccttga  gcggatctt  2940
cgagaccag  ccctctctc  ccaccacac  atggtggtt  aggccatca  cttcatctt  3000
aagtccctg  ggctcaagt  tgtgcagtt  ctgccccag  tcatgccca  gttccttaa  3060
gtcatccga  tctgtgatg  ggccatccg  gaatttctg  tccagcagc  gggaatgct  3120
gtgtccttt  tgaagagcc  catccgtcc  tacatggat  aaatagtca  cctcatgag  3180
gaattttgg  tcatgaaca  ctcaatcca  agcacaatc  ttcttctca  tgagcaaat  3240
gtggtggct  ttggaggtg  atttaagct  tacctgccc  agctgatcc  acacatgct  3300
cgtgtcttc  tgcatgaca  cagccaggg  cgcatagtc  ccatcaagc  gttagcagc  3360
atccagctg  ttggcgcca  cctggatga  tatctgcac  tgttgttgc  tccgatcgt  3420
aaattgttt  atgcccctg  agttccact  ccgtcgaga  aggcagcgt  ggagacagt  3480
gaccgcctg  cagagtccc  ggatttcac  gactatgcc  cccgcatca  tcacccgat  3540
gttcgcacg  tagaccaga  cccagagct  cgctccaca  ccatggaca  cctgtcttc  3600
cttgtgttt  aactaggga  gaagtacca  atcttcatt  caatggtga  taaagtcct  3660
gtgcgacac  ggatcaatc  ccagcgcta  gacgtgctg  tctgcagaa  cgtcaaggg  3720
tacacgctt  ctgatgaag  agaagaccc  ttgatttac  agcatcgaa  gctaaggag  3780
agccaggga  atgccctgg  cagtggacc  gttgaaaca  gacccatga  gaaactgca  3840
gtcagcacc  tcaacctcc  aaaggcctg  ggagctgcc  gaagggtct  caaggacga  3900
tggctggag  ggctgcgac  cttgagtct  gagctgctg  aggattcct  atcaccttc  3960
ctgcgctca  gctgggccc  ggcccaggc  tacaacccc  tggccaggg  tctcttcaa  4020
gctgcgttt  tgtcctgct  gtctgaact  aatgaagac  aacaagatg  gctcatcag  4080
agcattgag  tggctctca  ttctcaaga  attgctgaa  tcacacaaa  cctcttgaa  4140
ttggctgag  tcatggagc  cagtgacaa  ggcccccta  cactgagag  tgacaatgg  4200
atcgtgctg  tgggtgaga  agctgccaa  tgccgggca  atgccaaag  actacacta  4260
aaagagctg  agttccaga  ggggcccac  cctgccata  ttgagtccc  catcagcat  4320
aataataaa  tgcagcagc  tgaggcagc  tccggggtg  tagagtacg  catgaaaca  4380
ttcggagag  tggagatcc  ggccacctg  tatgagaag  tgcatgagt  ggaggacgc  4440
cttgtggcc  acgacaaga  gatggacac  aacaaggat  acccagagc  gatgctggg  4500
cgcatgcgc  gtctcgagg  cttgggaga  tggggccag  ttcatcagc  gtgctgtga  4560
aagtggact  tggttaatg  cgagaccca  gctaagatg  cccggatgg  tgctgcagc  4620
gcatggggt  taggtcagt  ggacagcat  gaggagtac  cctgtatga  tcctcggga  4680
actcacgat  gagcattct  cagagcagt  ttggcactg  atcaggatc  cttctcctt  4740
gctcaacag  gcattgaca  ggccaggga  ctgctggac  ccgagctga  tgccatggc  4800
ggggagagc  acagccgag  ctatggggc  atggtttct  gccacatgc  gtccgagct  4860
gaggaggtt  tccagtaca  actcgtccc  gagcgacgg  agatcatcc  ccagatctg  4920
tgggagaga  tgcagggct  ccagcgtat  gtagaggac  ggcagaaaa  cctcatggt  4980
cggtccctt  tggtcagcc  tcacgagga  atgagaacc  ggctcaagt  cgcaagcct  5040
tgtggcaag  gcggcagac  ggctcttgc  cataaaacc  tagtgttgc  cttgggagt  5100
gatccatct  ggcaacttg  ccatcctct  ccaacagtt  accctcaag  gacctatgc  5160
tacatgaaa  acatgtgga  aagcgctcg  aagattgat  ccttccagc  catgcagca  5220
tttgtgcag  ccatgcagc  gcaggccca  cacgccatt  ccacagagg  ccagcagca  5280
aagcaggag  tgcataagc  catggccag  tgttttctg  aacttgggg  gtggcagct  5340
aacctccag  gcatcaacg  gagcaccat  cccaaggtg  tacagtact  cagtgctgc  5400
acagagcat  accgcagct  gtataaggc  tggcacgca  gggcagtga  gaactttga  5460
gccgtgcta  actacaaac  tcagaacca  gcccgcgat  agaagaaga  actgcgcca  5520
gccagcggg  ccaacatca  caatgccac  accactgcc  ccaccgctg  ctccgctgc  5580
gctgccacc  gcacagagg  cagcaacag  gaaagtgaa  ccgagagca  tgagagcag  5640
cccaccccg  cccctctgc  gaagaaggt  actgaggat  tgtccaaaa  cctcttgtt  5700
tacactgtc  ctgctgtcc  aggcttctt  cgttctatc  ccttgtcga  aggcaacaa  5760
ctccaggat  cactcagag  cctcacctt  tggtttgat  atggtcact  gccagatgt  5820
aatgaagcc  tggtggaag  ggtgaaggc  atacagatt  acacttggt  acaggttat  5880
cctcagctc  ttgcaagaa  tgacacgcc  agacccttg  tgggccggc  cattcacca  5940
ctcctcaca  atattggtc  gtaccaccc  caggccctc  tctaccccc  gacggtggc  6000
tctaagtct  ccaccacag  ccgtcacaa  gcagccaac  agatcctga  gaacatgtg  6060
gagcacagc  acacgctag  ccagcaggc  atgatggtg  gtgaagagc  gattcgagt  6120
gccatcctc  ggcatgaga  gtggcatga  ggcctagaa  aggcctctc  cttgtactt  6180
ggggagagg  acgtcaaag  catgtttga  gtgctggag  ccctgcatg  tatgatgga  6240
cgcggtccc  agaccctga  ggaaacgtc  tttaatcag  catatggtc  agatttaat  6300
gaggcacaa  aatggtgcc  aaagtacat  aaatcaggg  acgtcaagg  cctcaccca  6360
gcctgggac  tctactatc  cgtgttcag  cggatctcc  agcagctac  acagctcac  6420
tccctggag  tgcagtatg  gtcccccaa  cttttgatg  gcagagacc  tgaattggc  6480
gtgccagga  catatgacc  caaccagcc  atcattcgc  ttcagtcca  agccccgtc  6540
ttgcaagtc  tcacatcca  gcagaggcc  cggaagctg  ccctgatgg  cagcaatgg  6600
cacgagttt  ttttcctcc  gaaaggcca  gaagatctg  ggcaggacg  gcgagtgat  6660
cagctcttt  gcctggtga  cacactcct  gccaatgac  caacttctc  tcgaaagaa  6720
ctcagcatc  agagatacg  cgtcattcc  ctgtccacc  actcgggcc  gattggctg  6780
gtgccccac  gtgacacgc  gcatgccct  atccgggac  acagagaga  gaagaagat  6840
ctgctgaac  tcgagcacc  catcatgct  cggatggct  ctgactatg  ccacctgac  6900
ctgatgcag  aggtggagg  gtttgagca  gctgtcaac  acacagccg  ggatgacct  6960
gccaagctg  tgtggctga  aagccccag  tcagaggtg  ggtttgacc  aagaaccaa  7020
tatactcgc  ccctggctg  catgtccat  gttggatac  ttttaggcc  tggagacag  7080
cacccatcc  acctgatgc  ggaccggct  agtggaaag  tcctgcaca  tgactttgg  7140
gactgcttt  aggttgcta  gaccagaga  aaatttcca  aaaagattc  atttagact  7200
acaagaatg  tgaccaatg  tatggaggt  accggtctc  atggcaact  tagaaccac  7260
tgccacaca  tgatggagg  gcttcggga  cacaaggac  gtgtcatgg  tgtgctaga  7320
gcctttgtc  atgaccctc  gctgaattg  aggctgatg  acacaaatg  caaaggcaa  7380
aagcggtcc  gaaccagga  agactccta  tctgcaggc  agtcagtag  aattttgga  7440
ggtgtagaa  ttggagaac  agcccataa  aaaacaggg  ccactgtgc  agaatccat  7500
cattctttc  ttggagatg  tttggtgaa  ccagaagcc  taaacaaga  agctattca  7560
attattaac  gggttcgag  taagctcac  ggtcgggat  tctctcatg  tgacacttt  7620
gatgttcca  cccaagtgg  actgcttat  aagcaagcg  catctcatg  gaacctctg  7680
cagtgctac  ttggctggt  tcctttctg  taaccaagg  ctggcaaag  aaatcatct  7740
ctccgatgc  tttgtacct  ggtctgtgc  tccagtgga  tgaaaccat  gtcataaag  7800
tggactttg  taatatttt  aaatgtata  gaaaagaac  actgtatat  caaagttgg  7860
ttatgccaa  ctcctagct  ctgttgaaa  gacactgtc  gaaacacaa  gcttgattc  7920
gttcccagg  cagtgaaac  cagtaatcc  acagaaacc  agcctttga  tttgggaga  7980
cagaagatg  gtaactgac  aagaaatac  ggtttggac  taacttaca  aagaactca  8040
catacgcat  tgctgaccg  ataatctag  tgatcctct  aaccagggg  ttcaacagc  8100
aggacacag  tgtcagcac  ccaccatcc  gttacctca  ccgtccctg  atgcagtgg  8160
aacatctgc  ggatgggcc  ccgtgtgtg  aagaagatc  gtcttccac  tgatcccat  8220
atgctgaac  tcacagagc  ggccttcca  gaaggacgt  tgctcagac  cctggccac  8280
gaggatgag  aggtgtgcc  ggatctcag  gcagggtcc  cgctggccc  gctgctgtg  8340
tcagtgagg  atggatatg  tgtgtttgc  gcagggact  agaacacaa  tgcttttgt  8400
gaagtgctg  tctcagagg  acactagcg  aggttgtga  ttaagagca  agtaaatat  8460
caactaaac  caaagtata  gtgaagcca  atctagaca  cattgtatc  gagtaattt  8520
tgtgccaat  aatgacatc  gaattttaa  agta  8554



<210> 8099
<211> 2549
<212> PRT
<213> Rattus norvegicus
<308> P42346
<400> 8099

Met Leu Gly Thr Gly Pro Ala Thr Ala Thr Ala Gly Ala Ala Thr Ser 
  1               5                  10                  15
Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 
             20                  25                  30
Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 
         35                  40                  45
Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 
     50                  55                  60
Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 
 65                  70                  75                  80
Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 
                 85                  90                  95
Glu Gly Gly Asn Ser Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 
             100                105                110
Asn Leu Leu Pro Ser Ser Asp Pro Val Val Met Glu Met Ala Ser Lys 
         115                120                125
Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 
     130                135                140
Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 
 145                150                155                160
Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 
                 165                170                175
Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 
             180                185                190
Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 
         195                200                205
Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 
     210                215                220
Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 
 225                230                235                240
Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 
                 245                250                255
Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 
             260                265                270
Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 
         275                280                285
Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 
     290                295                300
Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 
 305                310                315                320
Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 
                 325                330                335
Ser Ser His Gln Gly Leu Met Gly Phe Gly Ala Ser Pro Ser Pro Thr 
             340                345                350
Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 
         355                360                365
Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Ser Ser Lys 
     370                375                380
Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 
 385                390                395                400
Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 
                 405                410                415
Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 
             420                425                430
Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 
         435                440                445
Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 
     450                455                460
Pro Lys Asp Phe Ala His Lys Arg Gln Lys Thr Val Gln Val Asp Ala 
 465                470                475                480
Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 
                 485                490                495
Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 
             500                505                510
Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 
         515                520                525
Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 
     530                535                540
Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 
 545                550                555                560
Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 
                 565                570                575
Ser Asp Val Ala Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 
             580                585                590
Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 
         595                600                605
His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 
     610                615                620
Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 
 625                630                635                640
Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 
                 645                650                655
Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 
             660                665                670
Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 
         675                680                685
Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 
     690                695                700
Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 
 705                710                715                720
Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 
                 725                730                735
Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 
             740                745                750
Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 
         755                760                765
Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 
     770                775                780
Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 
 785                790                795                800
Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 
                 805                810                815
Val Asp Glu Leu Phe Val Ile Ile Met Asp Met Leu Gln Asp Ser Ser 
             820                825                830
Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 
         835                840                845
Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 
     850                855                860
Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 
 865                870                875                880
Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 
                 885                890                895
Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 
             900                905                910
Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 
         915                920                925
Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 
     930                935                940
Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 
 945                950                955                960
Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 
                 965                970                975
Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 
             980                985                990
Val Met Pro Thr Phe Leu Asn Val Ile Arg Val Cys Asp Gly Ala Ile 
         995                1000                1005
Arg Glu Phe Leu Phe Gln Gln Leu Gly Met Leu Val Ser Phe Val Lys 
     1010                1015                1020
Ser His Ile Arg Pro Tyr Met Asp Glu Ile Val Thr Leu Met Arg Glu 
 1025                1030                1035                1040
Phe Trp Val Met Asn Thr Ser Ile Gln Ser Thr Ile Ile Leu Leu Ile 
                 1045                1050                1055
Glu Gln Ile Val Val Ala Leu Gly Gly Glu Phe Lys Leu Tyr Leu Pro 
             1060                1065                1070
Gln Leu Ile Pro His Met Leu Arg Val Phe Met His Asp Asn Ser Gln 
         1075                1080                1085
Gly Arg Ile Val Ser Ile Lys Leu Leu Ala Ala Ile Gln Leu Phe Gly 
     1090                1095                1100
Ala Asn Leu Asp Asp Tyr Leu His Leu Leu Leu Pro Pro Ile Val Lys 
 1105                1110                1115                1120
Leu Phe Asp Ala Pro Glu Val Pro Leu Pro Ser Arg Lys Ala Ala Leu 
                 1125                1130                1135
Glu Thr Val Asp Arg Leu Thr Glu Ser Leu Asp Phe Thr Asp Tyr Ala 
             1140                1145                1150
Ser Arg Ile Ile His Pro Ile Val Arg Thr Leu Asp Gln Ser Pro Glu 
         1155                1160                1165
Leu Arg Ser Thr Ala Met Asp Thr Leu Ser Ser Leu Val Phe Gln Leu 
     1170                1175                1180
Gly Lys Lys Tyr Gln Ile Phe Ile Pro Met Val Asn Lys Val Leu Val 
 1185                1190                1195                1200
Arg His Arg Ile Asn His Gln Arg Tyr Asp Val Leu Ile Cys Arg Ile 
                 1205                1210                1215
Val Lys Gly Tyr Thr Leu Ala Asp Glu Glu Glu Asp Pro Leu Ile Tyr 
             1220                1225                1230
Gln His Arg Met Leu Arg Ser Ser Gln Gly Asp Ala Leu Ala Ser Gly 
         1235                1240                1245
Pro Val Glu Thr Gly Pro Met Lys Lys Leu His Val Ser Thr Ile Asn 
     1250                1255                1260
Leu Gln Lys Ala Trp Gly Ala Ala Arg Arg Val Ser Lys Asp Asp Trp 
 1265                1270                1275                1280
Leu Glu Trp Leu Arg Arg Leu Ser Leu Glu Leu Leu Lys Asp Ser Ser 
                 1285                1290                1295
Ser Pro Ser Leu Arg Ser Cys Trp Ala Leu Ala Gln Ala Tyr Asn Pro 
             1300                1305                1310
Met Ala Arg Asp Leu Phe Asn Ala Ala Phe Val Ser Cys Trp Ser Glu 
         1315                1320                1325
Leu Asn Glu Asp Gln Gln Asp Glu Leu Ile Arg Ser Ile Glu Leu Ala 
     1330                1335                1340
Leu Thr Ser Gln Asp Ile Ala Glu Val Thr Gln Thr Leu Leu Asn Leu 
 1345                1350                1355                1360
Ala Glu Phe Met Glu His Ser Asp Lys Gly Pro Leu Pro Leu Arg Asp 
                 1365                1370                1375
Asp Asn Gly Ile Val Leu Leu Gly Glu Arg Ala Ala Lys Cys Arg Ala 
             1380                1385                1390
Tyr Ala Lys Ala Leu His Tyr Lys Glu Leu Glu Phe Gln Lys Gly Pro 
         1395                1400                1405
Thr Pro Ala Ile Leu Glu Ser Leu Ile Ser Ile Asn Asn Lys Leu Gln 
     1410                1415                1420
Gln Pro Glu Ala Ala Ser Gly Val Leu Glu Tyr Ala Met Lys His Phe 
 1425                1430                1435                1440
Gly Glu Leu Glu Ile Gln Ala Thr Trp Tyr Glu Lys Leu His Glu Trp 
                 1445                1450                1455
Glu Asp Ala Leu Val Ala Tyr Asp Lys Lys Met Asp Thr Asn Lys Asp 
             1460                1465                1470
Asp Pro Glu Leu Met Leu Gly Arg Met Arg Cys Leu Glu Ala Leu Gly 
         1475                1480                1485
Glu Trp Gly Gln Leu His Gln Gln Cys Cys Glu Lys Trp Thr Leu Val 
     1490                1495                1500
Asn Asp Glu Thr Gln Ala Lys Met Ala Arg Met Ala Ala Ala Ala Ala 
 1505                1510                1515                1520
Trp Gly Leu Gly Gln Trp Asp Ser Met Glu Glu Tyr Thr Cys Met Ile 
                 1525                1530                1535
Pro Arg Asp Thr His Asp Gly Ala Phe Tyr Arg Ala Val Leu Ala Leu 
             1540                1545                1550
His Gln Asp Leu Phe Ser Leu Ala Gln Gln Cys Ile Asp Lys Ala Arg 
         1555                1560                1565
Asp Leu Leu Asp Ala Glu Leu Thr Ala Met Ala Gly Glu Ser Tyr Ser 
     1570                1575                1580
Arg Ala Tyr Gly Ala Met Val Ser Cys His Met Leu Ser Glu Leu Glu 
 1585                1590                1595                1600
Glu Val Ile Gln Tyr Lys Leu Val Pro Glu Arg Arg Glu Ile Ile Arg 
                 1605                1610                1615
Gln Ile Trp Trp Glu Arg Leu Gln Gly Cys Gln Arg Ile Val Glu Asp 
             1620                1625                1630
Trp Gln Lys Ile Leu Met Val Arg Ser Leu Val Val Ser Pro His Glu 
         1635                1640                1645
Asp Met Arg Thr Trp Leu Lys Tyr Ala Ser Leu Cys Gly Lys Ser Gly 
     1650                1655                1660
Arg Leu Ala Leu Ala His Lys Thr Leu Val Leu Leu Leu Gly Val Asp 
 1665                1670                1675                1680
Pro Ser Arg Gln Leu Asp His Pro Leu Pro Thr Val His Pro Gln Val 
                 1685                1690                1695
Thr Tyr Ala Tyr Met Lys Asn Met Trp Lys Ser Ala Arg Lys Ile Asp 
             1700                1705                1710
Ala Phe Gln His Met Gln His Phe Val Gln Thr Met Gln Gln Gln Ala 
         1715                1720                1725
Gln His Ala Ile Ala Thr Glu Asp Gln Gln His Lys Gln Glu Leu His 
     1730                1735                1740
Lys Leu Met Ala Arg Cys Phe Leu Lys Leu Gly Glu Trp Gln Leu Asn 
 1745                1750                1755                1760
Leu Gln Gly Ile Asn Glu Ser Thr Ile Pro Lys Val Leu Gln Tyr Tyr 
                 1765                1770                1775
Ser Ala Ala Thr Glu His Asp Arg Ser Trp Tyr Lys Ala Trp His Ala 
             1780                1785                1790
Trp Ala Val Met Asn Phe Glu Ala Val Leu His Tyr Lys His Gln Asn 
         1795                1800                1805
Gln Ala Arg Asp Glu Lys Lys Lys Leu Arg His Ala Ser Gly Ala Asn 
     1810                1815                1820
Ile Thr Asn Ala Thr Thr Thr Ala Thr Thr Ala Ala Ser Ala Ala Ala 
 1825                1830                1835                1840
Ala Thr Ser Thr Glu Gly Ser Asn Ser Glu Ser Glu Ala Glu Ser Asn 
                 1845                1850                1855
Glu Ser Ser Pro Thr Pro Ser Pro Leu Gln Lys Lys Val Thr Glu Asp 
             1860                1865                1870
Leu Ser Lys Thr Leu Leu Leu Tyr Thr Val Pro Ala Val Gln Gly Phe 
         1875                1880                1885
Phe Arg Ser Ile Ser Leu Ser Arg Gly Asn Asn Leu Gln Asp Thr Leu 
     1890                1895                1900
Arg Val Leu Thr Leu Trp Phe Asp Tyr Gly His Trp Pro Asp Val Asn 
 1905                1910                1915                1920
Glu Ala Leu Val Glu Gly Val Lys Ala Ile Gln Ile Asp Thr Trp Leu 
                 1925                1930                1935
Gln Val Ile Pro Gln Leu Ile Ala Arg Ile Asp Thr Pro Arg Pro Leu 
             1940                1945                1950
Val Gly Arg Leu Ile His Gln Leu Leu Thr Asp Ile Gly Arg Tyr His 
         1955                1960                1965
Pro Gln Ala Leu Ile Tyr Pro Leu Thr Val Ala Ser Lys Ser Thr Thr 
     1970                1975                1980
Thr Ala Arg His Asn Ala Ala Asn Lys Ile Leu Lys Asn Met Cys Glu 
 1985                1990                1995                2000
His Ser Asn Thr Leu Val Gln Gln Ala Met Met Val Ser Glu Glu Leu 
                 2005                2010                2015
Ile Arg Val Ala Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
             2020                2025                2030
Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
         2035                2040                2045
Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
     2050                2055                2060
Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
 2065                2070                2075                2080
Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
                 2085                2090                2095
Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
             2100                2105                2110
Lys Gln Leu Pro Gln Leu Thr Ser Leu Glu Leu Gln Tyr Val Ser Pro 
         2115                2120                2125
Lys Leu Leu Met Cys Arg Asp Leu Glu Leu Ala Val Pro Gly Thr Tyr 
     2130                2135                2140
Asp Pro Asn Gln Pro Ile Ile Arg Ile Gln Ser Ile Ala Pro Ser Leu 
 2145                2150                2155                2160
Gln Val Ile Thr Ser Lys Gln Arg Pro Arg Lys Leu Thr Leu Met Gly 
                 2165                2170                2175
Ser Asn Gly His Glu Phe Val Phe Leu Leu Lys Gly His Glu Asp Leu 
             2180                2185                2190
Arg Gln Asp Glu Arg Val Met Gln Leu Phe Gly Leu Val Asn Thr Leu 
         2195                2200                2205
Leu Ala Asn Asp Pro Thr Ser Leu Arg Lys Asn Leu Ser Ile Gln Arg 
     2210                2215                2220
Tyr Ala Val Ile Pro Leu Ser Thr Asn Ser Gly Leu Ile Gly Trp Val 
 2225                2230                2235                2240
Pro His Cys Asp Thr Leu His Ala Leu Ile Arg Asp Tyr Arg Glu Lys 
                 2245                2250                2255
Lys Lys Ile Leu Leu Asn Ile Glu His Arg Ile Met Leu Arg Met Ala 
             2260                2265                2270
Pro Asp Tyr Asp His Leu Thr Leu Met Gln Lys Val Glu Val Phe Glu 
         2275                2280                2285
His Ala Val Asn Asn Thr Ala Gly Asp Asp Leu Ala Lys Leu Leu Trp 
     2290                2295                2300
Leu Lys Ser Pro Ser Ser Glu Val Trp Phe Asp Arg Arg Thr Asn Tyr 
 2305                2310                2315                2320
Thr Arg Ser Leu Ala Val Met Ser Met Val Gly Tyr Ile Leu Gly Leu 
                 2325                2330                2335
Gly Asp Arg His Pro Ser Asn Leu Met Leu Asp Arg Leu Ser Gly Lys 
             2340                2345                2350
Ile Leu His Ile Asp Phe Gly Asp Cys Phe Glu Val Ala Met Thr Arg 
         2355                2360                2365
Glu Lys Phe Pro Glu Lys Ile Pro Phe Arg Leu Thr Arg Met Leu Thr 
     2370                2375                2380
Asn Ala Met Glu Val Thr Gly Leu Asp Gly Asn Tyr Arg Thr Thr Cys 
 2385                2390                2395                2400
His Thr Val Met Glu Val Leu Arg Glu His Lys Asp Ser Val Met Ala 
                 2405                2410                2415
Val Leu Glu Ala Phe Val Tyr Asp Pro Leu Leu Asn Trp Arg Leu Met 
             2420                2425                2430
Asp Thr Asn Ala Lys Gly Asn Lys Arg Ser Arg Thr Arg Thr Asp Ser 
         2435                2440                2445
Tyr Ser Ala Gly Gln Ser Val Glu Ile Leu Asp Gly Val Glu Leu Gly 
     2450                2455                2460
Glu Pro Ala His Lys Lys Thr Gly Thr Thr Val Pro Glu Ser Ile His 
 2465                2470                2475                2480
Ser Phe Ile Gly Asp Gly Leu Val Lys Pro Glu Ala Leu Asn Lys Lys 
                 2485                2490                2495
Ala Ile Gln Ile Ile Asn Arg Val Arg Asp Lys Leu Thr Gly Arg Asp 
             2500                2505                2510
Phe Ser His Asp Asp Thr Leu Asp Val Pro Thr Gln Val Glu Leu Leu 
         2515                2520                2525
Ile Lys Gln Ala Thr Ser His Glu Asn Leu Cys Gln Cys Tyr Ile Gly 
     2530                2535                2540
Trp Cys Pro Phe Trp 
 2545



<210> 8100
<211> 6210
<212> DNA
<213> Homo sapiens
<308> AK024393
<400> 8100

ctaaggaag  tgggctcgg  cccagtgtc  agtgtccat  ttttcttta  tttctttta  60
aaactaaag  gaagggaat  aaccatttc  gagcatcaa  cgaaacaag  taaaagaat  120
gatctttgc  tagaagaat  actagttgt  tcaagtctc  tatgctaca  actgtgtct  180
tttgaatac  aggttatac  tcagctcat  gcaagaatt  atacgccca  acccttggt  240
ggacgtctc  ttcaccagc  tctcacaga  attggtcgg  accaccccc  ggtatgtgg  300
gactctggg  agtttctca  ctaaccact  gtttggtgg  cagcctttc  aaaagctgc  360
ctggcgaca  aagcgcagg  actgggagc  atgtgttcc  tcctggccc  ggagggtct  420
tccagccag  cgtcccaga  ggcccggga  ccttgctaa  aagaaagcg  tccctcgaa  480
actgagccc  ttcctggta  tctcaagca  atgttaatg  cacactcac  acttgtttt  540
ttattctcc  taaaattca  accagctct  ccccaaccc  catttcctt  atagatgtt  600
cttctgttt  tccctcagg  cctcatcta  ccactgaca  tggcttcta  gtctaccac  660
acagcccgg  acaatgcag  caacaagat  ctgaagaac  tgtgtgagc  cagcaacac  720
ctggtccag  aggccatga  ggtgggtcg  agccactgt  gggcttcat  gaccctggt  780
ccttagctg  tgggcgcaa  tgggattgt  tttcttcct  gcattggtg  tgtgcactt  840
ctctgactg  tggaaatag  acctcctgt  tctccaaaa  agacctttc  gaggttagc  900
gattcttgg  gcttctctc  ttcttctct  ggcttcagg  gagcgagga  ctgatccga  960
tggccatcc  ctggcatga  atgtggcat  aaggcctgg  agaggcatc  cgtttgtac  1020
ttggggaaa  gaacgtgaa  ggcatgttt  aggtgctgg  gcccttgca  gctatgatg  1080
aacggggcc  ccagactct  aaggaaaca  cctttaatc  ggtatgggg  aaaaaaaca  1140
gaaaggaca  aaccctgta  aaatattct  ccactaaaa  aaaatgaaa  gagaaaagt  1200
tttatagaa  gaaaggacg  gacccaagg  ctttgtcag  tttcttttc  tctggcctt  1260
ccactgact  taataaaac  agctctgat  gaggtcaca  agcataaaa  atcagaaat  1320
agttacagg  acccttctg  attttaact  gaaaagccc  agatttctc  agaggtcat  1380
tcgtctctc  tctcaccct  ccttcccta  aagccatgc  gctggtttg  aagctccag  1440
gttggaggc  tgcacctat  ctcttgctt  ctccagccc  ctgccagtg  tttcaggcc  1500
cagcgggct  ctgaggaat  tctgcagtc  gcctgggga  tttgcctcc  gggttggtt  1560
agactttga  aacttgaaa  cgtgcctgc  ttctctctc  ggcctatgg  cgagattta  1620
tggaggccc  agagtggtg  aggaagtac  tgaaatcag  gaatgtcaa  gacctcacc  1680
aagcctggg  cctctatta  catgtgttc  gacgaatct  aaagcagct  cctcaggta  1740
gatcttcag  ctcctggca  ggttaactg  cattatagt  ctttctgtt  tactgtcta  1800
gaatgttct  acactcatt  caaagcatc  ggttttact  ctgctttgg  acaagtaat  1860
gttattagc  atccactga  aaatactta  attgcgttt  aattcttcc  tggaggcag  1920
acactaaat  ctttggtaa  tatttacag  tcacatcct  agagctgca  tatgtttcc  1980
caaaacttc  gatgtgccg  gaccttgaa  tggctgtgc  aggaacata  gaccccaac  2040
agccaatca  tcgcattca  tccatagca  cgtctttgc  agtcatcac  tccaagcag  2100
ggccccgga  attgacact  atgggtaag  accattgtg  acttctgtc  cccacttct  2160
cctcctaca  tggctgaga  cccttccct  ttctgaaat  actgcttgc  attcccact  2220
ctcacctat  atagctaca  ctctcccat  ctcattgag  ggaaaatag  gggcaagca  2280
atttctcat  atgtcctca  gacttagtt  attcatgta  ttgggctta  gtgaagcat  2340
atcacacat  aagggaatg  caaaggcat  caaggcaga  aagtaacag  ggaaggcag  2400
tgttggaga  tgatgaggc  agggaggag  cagctgggt  caagcaggg  aggtgctag  2460
tcctctgaa  tgggggctt  tggctcttg  aattttttt  ttttttttt  taccatcat  2520
gtctctgtg  taaatgatt  tgtaaaatg  acaagtgga  tctcacagt  agatttgtt  2580
agcaagtgg  ctctggaat  tcccttggg  tagagtgtt  cttatgggg  atgttttag  2640
gaggcctga  tgctgtggt  gcactttga  gcctctcgc  ttttttttt  ttttttgag  2700
cagagtttt  ctcttgttg  ccaggctgg  gtataatgg  gcaatcttg  ctcactgca  2760
cctccacct  ccaggttca  gcaattctc  tgtctcagc  tcccgcgta  ctgggatta  2820
aggcacgca  caccacacc  agctaattt  tgtattttt  atagagttg  ggtttcacc  2880
tgttggcca  gctggtctc  aactctgac  tcaagtgat  agcctgtct  agccttcca  2940
agtgctggg  ttacaggtg  gaaccactg  gcccagcca  ctcttgctc  ttttttttt  3000
ttttcccca  gacagagtc  cactctgtt  cccaggctg  agtgaggtg  tgtgttctc  3060
gctcactgc  tccccacct  ctgagttca  gcgattctc  tgcctcagc  tccctaata  3120
ctgagatta  aggcgcatg  cacacaatc  gctaatttt  atattttta  tagagatgg  3180
atttcacca  gttggccag  ctggtctca  actcccgac  tgaggtgat  cgcccagct  3240
ggcctccca  aatgttagg  ttacaggtg  gagccaccg  gcccagcct  acctctcgc  3300
cttaataat  ctcaatgtt  cttaaatgc  gtgattatt  accaacacc  attaatcat  3360
gtccacagg  gattatctc  gcatgagct  ttgtcttct  atacaaaat  tgggtcagg  3420
tggttcttg  ggtgtttaa  taaagagag  ttaaggaag  aattgtttc  agaggtgta  3480
gcaaagcta  gagaatcaa  aaggagcgc  catgaacaa  cacaagtga  aaattgtta  3540
tcagccctc  cccaccccc  cactccaga  ctgaaagag  aaggagccc  gctagaacc  3600
tcaccatgc  agagaggcc  tctagcaga  tctacagtc  agagagagt  gtagcttct  3660
gaactgggg  caggctggt  atgggggac  cataccctg  cctctccct  tacccatcc  3720
ctgacctcc  gccagtacc  ttccaccat  ggccacgcc  aagtgggat  ccaggtgat  3780
cggcttgta  gagtcaggc  tctcagaac  gaggaggac  gagtgggtc  gaaaacagg  3840
atgatcatt  ccatgccta  ccgttcctg  tcctcaaaa  cagattttg  tttgtttta  3900
tttgaacaa  actggtcat  gagaaccat  aaaggcaaa  ccactcttt  cattaattc  3960
aaagattgt  ttttctttt  gtgaggaac  tgtgattag  taaggcata  gtagtctgt  4020
ggatctctt  aatgcagtg  tgctctcag  tgaagagct  aggacctct  atgtacact  4080
accgctccc  ctgttcctt  caggcagca  cggacatga  tttgttttc  ttctaaaag  4140
ccaagaaga  ctgcgccag  atgagcgtg  gatgcagct  ttcggcctg  ttaacaccc  4200
tctggccaa  gacccaaca  ctcttcgga  aaacctcag  tattcagaa  ccctgaaat  4260
gcaacaatt  gagaagtct  ctggttttt  cctacattt  tctcgtgta  tcatgtatt  4320
tatcttaac  aaaaactat  aaattaggg  gccaggcat  gtaactcat  cctgtagtc  4380
cagaaactc  agaggttga  gcaggggga  ggcttgagc  caggagttc  aggctgcag  4440
gagctgtga  tgtgccact  ccctccagc  tgggtaata  agcaagact  tctctttag  4500
agaaaaagg  tgggcatgg  ggctcgcac  tataatcct  atattttgt  atgccaagg  4560
aggaggatc  cttgagccc  ggaattcaa  accagccta  acaacatag  gagacccca  4620
cactattta  ttaaaaaaa  taaaaaggt  accgggcac  gtggcccat  cctataatc  4680
cagcacttt  ggaggccca  gcaggtgga  cacttgagg  caggagttc  agaccagcc  4740
ggccaacat  gtgaaaccc  gtgtctact  aaaatacaa  aattagctg  gcgtggtgg  4800
ggccacctg  aatcccggc  actcaggag  ctgaggcac  agaattgct  gaacctggg  4860
ggcggaggt  gcagtgagc  aagattgca  cattgtact  caggctggg  aacaagagt  4920
aaactccat  tcaaaaata  ataactaaa  taaggaaaa  aaaaattaa  tggccaggc  4980
tggtggctc  catgtaatc  cgacacttt  gaaggctac  gcaggagga  tgcttgaga  5040
caggagttc  agaccatcc  ggacaaaaa  gtgagaccc  gtctctaca  aaaataaaa  5100
aatcagctg  gcatggtgg  tcatgcctg  tgtcccagc  ccttgggag  tggaggcag  5160
agaatcatc  tagcccagt  ggttgaggc  gcagtgaga  aaggttgtg  ctctacact  5220
tagcctggg  agcagagca  gaccctttc  ctcaaaaaa  aaagatagg  tgggcacag  5280
gactcacgc  tgtaatccc  gtctctaca  aaaaaaaaa  aaaaaaagc  gggcacagt  5340
tagtcccag  tactcaggg  gctgaggca  gagaatcac  tgagcccag  aggtcgagg  5400
tacagtgag  tgtgatggg  caactgtgc  cgagcctag  taacagcga  accctatct  5460
aaaaagtaa  taatatttt  taaatgttt  aaaaatgaa  aattaagtt  taaaatttt  5520
taatttata  ccaagttct  ccagagttt  tagggtatt  tcattggga  atgccttta  5580
caacctcca  agaatccag  agggagcaa  ttgtggcgg  tagactgga  agtctacag  5640
tgggatggg  ctgacccct  gtgggatga  agccaaacc  ttcccatcg  ccgtattct  5700
gcactcctc  tcctgttaa  accatgaga  ttcacttga  aggtatttt  gtcacttga  5760
tgttccccc  aagccatga  tttcttggg  aggttgagg  gacctgtgt  gctttcact  5820
caccatcag  gcactgtct  tctgtgatg  cttattctt  acaaagcat  cctcaacac  5880
cacttcaca  cagcctgct  cggcggggg  tcattaaaa  tagtcaggg  cgccgggcg  5940
ggtggctca  gcctgtaat  ccagcactt  gggaggcca  ggagggtgg  tcacgaggt  6000
aggagttcg  gaccagtct  gccaacata  tgaaacccc  tctctacta  aaatacaaa  6060
aattagccg  gtgtggtgt  gtgcatctg  aatcccagc  actcgggag  ctgacgcag  6120
agaatcgct  gaacccagg  ggcagaggt  gcagtgaac  aaaatagtg  cactgcatt  6180
cagcctggg  aacagaaca  gactccatct  6210



<210> 8101
<211> 1417
<212> PRT
<213> Homo sapiens
<308> CAB44736
<400> 8101

Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser 
  1               5                  10                  15
Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 
             20                  25                  30
Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 
         35                  40                  45
Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 
     50                  55                  60
Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 
 65                  70                  75                  80
Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 
                 85                  90                  95
Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 
             100                105                110
Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys 
         115                120                125
Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 
     130                135                140
Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 
 145                150                155                160
Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 
                 165                170                175
Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 
             180                185                190
Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 
         195                200                205
Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 
     210                215                220
Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 
 225                230                235                240
Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 
                 245                250                255
Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 
             260                265                270
Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 
         275                280                285
Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 
     290                295                300
Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 
 305                310                315                320
Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 
                 325                330                335
Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 
             340                345                350
Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 
         355                360                365
Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys 
     370                375                380
Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 
 385                390                395                400
Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 
                 405                410                415
Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 
             420                425                430
Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 
         435                440                445
Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 
     450                455                460
Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala 
 465                470                475                480
Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 
                 485                490                495
Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 
             500                505                510
Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 
         515                520                525
Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 
     530                535                540
Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 
 545                550                555                560
Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 
                 565                570                575
Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 
             580                585                590
Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 
         595                600                605
His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 
     610                615                620
Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 
 625                630                635                640
Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 
                 645                650                655
Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 
             660                665                670
Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 
         675                680                685
Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 
     690                695                700
Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 
 705                710                715                720
Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 
                 725                730                735
Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 
             740                745                750
Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 
         755                760                765
Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 
     770                775                780
Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 
 785                790                795                800
Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 
                 805                810                815
Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 
             820                825                830
Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 
         835                840                845
Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 
     850                855                860
Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 
 865                870                875                880
Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 
                 885                890                895
Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 
             900                905                910
Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 
         915                920                925
Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 
     930                935                940
Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 
 945                950                955                960
Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 
                 965                970                975
Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 
             980                985                990
Val Met Pro Thr Phe Leu Asn Val Ile Arg Val Cys Asp Gly Ala Ile 
         995                1000                1005
Arg Glu Phe Leu Phe Gln Gln Leu Gly Met Leu Val Ser Phe Val Lys 
     1010                1015                1020
Ser His Ile Arg Pro Tyr Met Asp Glu Ile Val Thr Leu Met Arg Glu 
 1025                1030                1035                1040
Phe Trp Val Met Asn Thr Ser Ile Gln Ser Thr Ile Ile Leu Leu Ile 
                 1045                1050                1055
Glu Gln Ile Val Val Ala Leu Gly Gly Glu Phe Lys Leu Tyr Leu Pro 
             1060                1065                1070
Gln Leu Ile Pro His Met Leu Arg Val Phe Met His Asp Asn Ser Pro 
         1075                1080                1085
Gly Arg Ile Val Ser Ile Lys Leu Leu Ala Ala Ile Gln Leu Phe Gly 
     1090                1095                1100
Ala Asn Leu Asp Asp Tyr Leu His Leu Leu Leu Pro Pro Ile Val Lys 
 1105                1110                1115                1120
Leu Phe Asp Ala Pro Glu Ala Pro Leu Pro Ser Arg Lys Ala Ala Leu 
                 1125                1130                1135
Glu Thr Val Asp Arg Leu Thr Glu Ser Leu Asp Phe Thr Asp Tyr Ala 
             1140                1145                1150
Ser Arg Ile Ile His Pro Ile Val Arg Thr Leu Asp Gln Ser Pro Glu 
         1155                1160                1165
Leu Arg Ser Thr Ala Met Asp Thr Leu Ser Ser Leu Val Phe Gln Leu 
     1170                1175                1180
Gly Lys Lys Tyr Gln Ile Phe Ile Pro Met Val Asn Lys Val Leu Val 
 1185                1190                1195                1200
Arg His Arg Ile Asn His Gln Arg Tyr Asp Val Leu Ile Cys Arg Ile 
                 1205                1210                1215
Val Lys Gly Tyr Thr Leu Ala Asp Glu Glu Glu Asp Pro Leu Ile Tyr 
             1220                1225                1230
Gln His Arg Met Leu Arg Ser Gly Gln Gly Asp Ala Leu Ala Ser Gly 
         1235                1240                1245
Pro Val Glu Thr Gly Pro Met Lys Lys Leu His Val Ser Thr Ile Asn 
     1250                1255                1260
Leu Gln Lys Ala Trp Gly Ala Ala Arg Arg Val Ser Lys Asp Asp Trp 
 1265                1270                1275                1280
Leu Glu Trp Leu Arg Arg Leu Ser Leu Glu Leu Leu Lys Asp Ser Ser 
                 1285                1290                1295
Ser Pro Ser Leu Arg Ser Cys Trp Ala Leu Ala Gln Ala Tyr Asn Pro 
             1300                1305                1310
Met Ala Arg Asp Leu Phe Asn Ala Ala Phe Val Ser Cys Trp Ser Glu 
         1315                1320                1325
Leu Asn Glu Asp Gln Gln Asp Glu Leu Ile Arg Ser Ile Glu Leu Ala 
     1330                1335                1340
Leu Thr Ser Gln Asp Ile Ala Glu Val Thr Gln Thr Leu Leu Asn Leu 
 1345                1350                1355                1360
Ala Glu Phe Met Glu His Ser Asp Lys Gly Pro Leu Pro Leu Arg Asp 
                 1365                1370                1375
Asp Asn Gly Ile Val Leu Leu Gly Glu Arg Ala Ala Lys Cys Arg Ala 
             1380                1385                1390
Tyr Ala Lys Ala Leu His Tyr Lys Glu Leu Glu Phe Gln Lys Gly Pro 
         1395                1400                1405
Thr Pro Ala Ile Leu Glu Ser Leu Ile 
     1410                1415



<210> 8102
<211> 1723
<212> DNA
<213> Rattus norvegicus
<308> U11685
<400> 8102

taatgtcca  ggctccagg  agagatgtc  ttgtggctg  aggccgcag  gcctgatgt  60
tctcctgac  ctgcaacgg  gttgtggaa  acagaacct  aagatgcag  agaccaggg  120
ggcaacact  gcatcctta  ggaggaagc  aggatgccc  aatcaactg  gggtgcttt  180
aggataggg  tggagtcat  cgagcctac  gccctgctc  ccagggcag  gaccctccc  240
gagcctaca  aacttcgtc  acagaagcg  aaaaagggg  cagccccca  aatgctggg  300
aacgagcta  gcagtgtat  tggggacaa  gcctctgcg  tccattaca  tgtgctgag  360
tgcgagggc  gcaagggat  cttccgccg  agtgtcatc  agggagcac  ctacatttg  420
catagcggt  gccactgcc  catggacac  tacatgcgg  ggaaatgcc  ggagtgtcg  480
cttcgcaaa  gccgccacg  aggcatgag  gaggagtgt  tcttatcag  agaacagat  540
cgcttgaag  aactgaagc  tcaagaaga  gagcaggct  aagccacat  ggtgtcccc  600
agggtttcc  caccgcccc  ggtcctgcc  cagctcagc  cagaacaac  gggcatgat  660
gagaagttg  tggctgccc  gcaacagtg  aacaggcgc  ccttctctg  ccgacttcg  720
gtcacgcct  ggcccattg  acccgaccc  cagagccgg  aagcccgcc  acagcgctt  780
gcccacttt  ctgagctgg  catcgtgtc  gtgcaggag  ttgttgact  tgccaaaca  840
ctccctggc  tcctacagc  gagcaggga  gaccagatc  ccttgctga  gacctctgc  900
atcgaggtg  tgcttctgg  gacatcgcg  aggtacaac  ctgggagtg  gagcatcac  960
ttcctcaag  atttcagtt  caaccggga  gactttgcc  aagcagggc  gcaggtgga  1020
ttcattaac  ccatctttg  gttctccag  tccatgaat  aactgcaac  caatgatgc  1080
gaatttgct  tgctcatag  catcagcat  ttctctgca  accggccca  cgtgcagga  1140
cagctccaa  tagagagac  gcaacacac  tatgtggag  ccctgcatg  ctatgtctc  1200
atcaaccac  cccacgacc  actgatgtt  ccacggatg  taatgaagc  ggtgagcct  1260
cggactttg  gcagcgtcc  ttcagagca  gtgtttgca  ttcgcctgc  ggacaaaaa  1320
cttccccct  tgctctccg  gatctggga  gtccacgaa  gactgtttc  ccgtgtcct  1380
tgtgttggc  acgcagctg  agcttactg  ctgcttcct  gaggtggag  agactgagg  1440
gggcaaaca  tcctgggcg  tgggtgaaa  agacccttg  atggcacta  agagagtca  1500
agggttggg  gttttgtgg  tgctgggca  ttggggacc  actaacgtt  tatgccatc  1560
gaaggcctt  ttgacccaa  caaataaac  agccaggag  gccactttg  gcagggttc  1620
tcaggccct  cccaaaaaa  aaaaaaaaa  acgactaac  ttgtatgcc  tctgaaggc  1680
ttgttgacc  aaccaaata  actagccag  agagccact  tgt  1723



<210> 8103
<211> 445
<212> PRT
<213> Rattus norvegicus
<308> Q62685
<400> 8103

Met Ser Leu Trp Leu Glu Ala Ala Val Pro Asp Val Ser Pro Asp Ser 
  1               5                  10                  15
Ala Thr Glu Leu Trp Lys Thr Glu Pro Gln Asp Ala Gly Asp Gln Gly 
             20                  25                  30
Gly Asn Thr Cys Ile Leu Arg Glu Glu Ala Arg Met Pro Gln Ser Thr 
         35                  40                  45
Gly Gly Ala Leu Arg Ile Gly Leu Glu Ser Ser Glu Pro Thr Ala Leu 
     50                  55                  60
Leu Pro Arg Ala Glu Thr Leu Pro Glu Pro Thr Glu Leu Arg Pro Gln 
 65                  70                  75                  80
Lys Arg Lys Lys Gly Pro Ala Pro Lys Met Leu Gly Asn Glu Leu Cys 
                 85                  90                  95
Ser Val Cys Gly Asp Lys Ala Ser Ala Phe His Tyr Asn Val Leu Ser 
             100                105                110
Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Val Ile Lys Gly Ala 
         115                120                125
Arg Tyr Ile Cys His Ser Gly Gly His Cys Pro Met Asp Thr Tyr Met 
     130                135                140
Arg Arg Lys Cys Gln Glu Cys Arg Leu Arg Lys Cys Arg His Ala Gly 
 145                150                155                160
Met Arg Glu Glu Cys Val Leu Ser Glu Glu Gln Ile Arg Leu Lys Lys 
                 165                170                175
Leu Lys Arg Gln Glu Glu Glu Gln Ala Gln Ala Thr Ser Val Ser Pro 
             180                185                190
Arg Val Ser Ser Pro Pro Gln Val Leu Pro Gln Leu Ser Pro Glu Gln 
         195                200                205
Leu Gly Met Ile Glu Lys Leu Val Ala Ala Gln Gln Gln Cys Asn Arg 
     210                215                220
Arg Ser Phe Ser Asp Arg Leu Arg Val Thr Pro Trp Pro Ile Ala Pro 
 225                230                235                240
Asp Pro Gln Ser Arg Glu Ala Arg Gln Gln Arg Phe Ala His Phe Thr 
                 245                250                255
Glu Leu Ala Ile Val Ser Val Gln Glu Ile Val Asp Phe Ala Lys Gln 
             260                265                270
Leu Pro Gly Phe Leu Gln Leu Ser Arg Glu Asp Gln Ile Ala Leu Leu 
         275                280                285
Lys Thr Ser Ala Ile Glu Val Met Leu Leu Glu Thr Ser Arg Arg Tyr 
     290                295                300
Asn Pro Gly Ser Glu Ser Ile Thr Phe Leu Lys Asp Phe Ser Tyr Asn 
 305                310                315                320
Arg Glu Asp Phe Ala Lys Ala Gly Leu Gln Val Glu Phe Ile Asn Pro 
                 325                330                335
Ile Phe Glu Phe Ser Arg Ser Met Asn Glu Leu Gln Leu Asn Asp Ala 
             340                345                350
Glu Phe Ala Leu Leu Ile Ala Ile Ser Ile Phe Ser Ala Asp Arg Pro 
         355                360                365
Asn Val Gln Asp Gln Leu Gln Val Glu Arg Leu Gln His Thr Tyr Val 
     370                375                380
Glu Ala Leu His Ala Tyr Val Ser Ile Asn His Pro His Asp Arg Leu 
 385                390                395                400
Met Phe Pro Arg Met Leu Met Lys Leu Val Ser Leu Arg Thr Leu Ser 
                 405                410                415
Ser Val His Ser Glu Gln Val Phe Ala Leu Arg Leu Gln Asp Lys Lys 
             420                425                430
Leu Pro Pro Leu Leu Ser Glu Ile Trp Asp Val His Glu 
         435                440                445



<210> 8104
<211> 1524
<212> DNA
<213> Homo sapiens
<308> BC008819
<400> 8104

ggcacgagg  ctgcttgtg  tcagctcca  ctcactggc  ggccaccga  acttctgga  60
aggaaactg  accatcctc  tctcccagc  agggggctc  agagactgc  cacccagga  120
gtctggtgg  ctggggatt  ggacagtgc  ttggtaatg  ccagggctc  aggaagaga  180
gtccttgtg  ctgggggcc  ctgtgcctg  cattcctcc  gactctgcg  tggagctgt  240
gaagccagg  gcacaggat  caagcagcc  ggcccaggg  ggcagcagc  gcatcctca  300
agaggaagc  aggatgccc  actctgctg  gggtactgc  ggggtgggg  tggaggctg  360
agagcccac  gccctgctc  ccagggcag  gcccccttc  gaacccaca  agatccgtc  420
acaaaagcg  aaaaagggg  cagccccca  aatgctggg  aacgagcta  gcagcgtgt  480
tggggacaa  gcctcgggc  tccactaca  tgttctgag  tgcgagggc  gcaagggat  540
cttccgccg  agcgtcatc  agggagcgc  ctacatctg  cacagtggc  gccactgcc  600
catggacac  tacatgcgt  gcaagtgcc  ggagtgtcg  cttcgcaaa  gccgtcagg  660
tggcatgcg  gaggagtgt  tcctgtcag  agaacagat  cgcctgaag  aactgaagc  720
gcaagagga  gaacaggct  atgccacat  cttgccccc  agggcttcc  caccccccc  780
aatcctgcc  cagctcagc  cggaacaac  gggcatgat  gagaagctc  tcgctgccc  840
gcaacagtg  aaccggcgc  ccttttctg  ccggcttcg  gtcacggtg  tgcttctgg  900
gacatctcg  aggtacaac  ctgggagtg  gagtatcac  ttcctcaag  atttcagtt  960
taaccggga  gactttgcc  aagcagggc  gcaagtgga  ttcatcaac  ccatcttcg  1020
gttctccag  gccatgaat  agctgcaac  caatgatgc  gagtttgcc  tgctcattg  1080
tatcagcat  ttctctgca  accggccca  cgtgcagga  cagctccag  tagagaggc  1140
gcagcacac  tatgtggaa  ccctgcatg  ctacgtctc  atccaccat  cccatgacc  1200
actgatgtt  ccacggatg  taatgaaac  ggtgagcct  cggaccctg  gcagcgtcc  1260
ctcagagca  gtgtttgca  tgcgtctgc  ggacaaaaa  ctcccaccg  tgctctctg  1320
gatctggga  gtgcacgaa  gactgttct  tccccatat  ttctgtttt  ttggccgga  1380
ggctgaggc  tggtggctg  ctcctagaa  tggaacaga  tgagaaggg  aaacattcc  1440
gggagctgg  caaggagat  ctcccgtgg  attaaaaga  agtcaaagg  aaaaaaaaa  1500
aaaaaaaaa  aaaaaaaaa  aaaa  1524



<210> 8105
<211> 447
<212> PRT
<213> Homo sapiens
<308> Q13133
<400> 8105

Met Ser Leu Trp Leu Gly Ala Pro Val Pro Asp Ile Pro Pro Asp Ser 
  1               5                  10                  15
Ala Val Glu Leu Trp Lys Pro Gly Ala Gln Asp Ala Ser Ser Gln Ala 
             20                  25                  30
Gln Gly Gly Ser Ser Cys Ile Leu Arg Glu Glu Ala Arg Met Pro His 
         35                  40                  45
Ser Ala Gly Gly Thr Ala Gly Val Gly Leu Glu Ala Ala Glu Pro Thr 
     50                  55                  60
Ala Leu Leu Thr Arg Ala Glu Pro Pro Ser Glu Pro Thr Glu Ile Arg 
 65                  70                  75                  80
Pro Gln Lys Arg Lys Lys Gly Pro Ala Pro Lys Met Leu Gly Asn Glu 
                 85                  90                  95
Leu Cys Ser Val Cys Gly Asp Lys Ala Ser Gly Phe His Tyr Asn Val 
             100                105                110
Leu Ser Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Val Ile Lys 
         115                120                125
Gly Ala His Tyr Ile Cys His Ser Gly Gly His Cys Pro Met Asp Thr 
     130                135                140
Tyr Met Arg Arg Lys Cys Gln Glu Cys Arg Leu Arg Lys Cys Arg Gln 
 145                150                155                160
Ala Gly Met Arg Glu Glu Cys Val Leu Ser Glu Glu Gln Ile Arg Leu 
                 165                170                175
Lys Lys Leu Lys Arg Gln Glu Glu Glu Gln Ala His Ala Thr Ser Leu 
             180                185                190
Pro Pro Arg Arg Ser Ser Pro Pro Gln Ile Leu Pro Gln Leu Ser Pro 
         195                200                205
Glu Gln Leu Gly Met Ile Glu Lys Leu Val Ala Ala Gln Gln Gln Cys 
     210                215                220
Asn Arg Arg Ser Phe Ser Asp Arg Leu Arg Val Thr Pro Trp Pro Met 
 225                230                235                240
Ala Pro Asp Pro His Ser Arg Glu Ala Arg Gln Gln Arg Phe Ala His 
                 245                250                255
Phe Thr Glu Leu Ala Ile Val Ser Val Gln Glu Ile Val Asp Phe Ala 
             260                265                270
Lys Gln Leu Pro Gly Phe Leu Gln Leu Ser Arg Glu Asp Gln Ile Ala 
         275                280                285
Leu Leu Lys Thr Ser Ala Ile Glu Val Met Leu Leu Glu Thr Ser Arg 
     290                295                300
Arg Tyr Asn Pro Gly Ser Glu Ser Ile Thr Phe Leu Lys Asp Phe Ser 
 305                310                315                320
Tyr Asn Arg Glu Asp Phe Ala Lys Ala Gly Leu Gln Val Glu Phe Ile 
                 325                330                335
Asn Pro Ile Phe Glu Phe Ser Arg Ala Met Asn Glu Leu Gln Leu Asn 
             340                345                350
Asp Ala Glu Phe Ala Leu Leu Ile Ala Ile Ser Ile Phe Ser Ala Asp 
         355                360                365
Arg Pro Asn Val Gln Asp Gln Leu Gln Val Glu Arg Leu Gln His Thr 
     370                375                380
Tyr Val Glu Ala Leu His Ala Tyr Val Ser Ile His His Pro His Asp 
 385                390                395                400
Arg Leu Met Phe Pro Arg Met Leu Met Lys Leu Val Ser Leu Arg Thr 
                 405                410                415
Leu Ser Ser Val His Ser Glu Gln Val Phe Ala Leu Arg Leu Gln Asp 
             420                425                430
Lys Lys Leu Pro Pro Leu Leu Ser Glu Ile Trp Asp Val His Glu 
         435                440                445



<210> 8106
<211> 783
<212> DNA
<213> Rattus norvegicus
<308> U12568
<400> 8106

ctcggcttg  ggatgggct  gctctctat  ttgcgcaaa  tgaaaagtg  accagacca  60
gaggtgcga  tcctcctcc  gggcttgga  aacgctggc  agacgaccc  gctgaagca  120
cttgcatct  aagacatca  ccacatcac  cctacacag  gatttaaca  caaaagtgt  180
cagtcacaa  gttttaaac  gaatgtatg  gacattggc  gacagagga  aatcagacc  240
tactggaga  gctattttg  aaacactga  attcttata  acgtaattg  cagtgcaga  300
agaaaaaga  ttgaagaga  gggtcagga  ctaacggaa  tgctggagg  agaaaagct  360
agctgtgtg  cagtgctcg  ctttgctaa  aagcaggat  tgctcacgg  ggccccagc  420
gcagagatc  cagaagggc  aaacctaca  accattcgg  accgcgtct  gcagatcca  480
tcctgctca  cgctcacag  cgagggcgt  caggacggc  tgaactggg  ctgcaagaa  540
gtcaacgca  agaagaagt  agatgccga  ggaggcgcg  agctcggga  ctggtcccg  600
cctgagaaa  aaacactgc  tgcgctttc  gaccaaagg  tttcccatc  gcacggcca  660
agctgtgtg  tgggcgggg  cagcagctt  agaggaacc  ccattccag  agtagattt  720
aactgatct  agaggttca  tatcgtttt  caaataaag  aattatatt  tttcctctg  780
ata  783



<210> 8107
<211> 182
<212> PRT
<213> Rattus norvegicus
<308> P37996
<400> 8107

Met Gly Leu Leu Ser Ile Leu Arg Lys Leu Lys Ser Ala Pro Asp Gln 
  1               5                  10                  15
Glu Val Arg Ile Leu Leu Leu Gly Leu Asp Asn Ala Gly Lys Thr Thr 
             20                  25                  30
Leu Leu Lys Gln Leu Ala Ser Glu Asp Ile Ser His Ile Thr Pro Thr 
         35                  40                  45
Gln Gly Phe Asn Ile Lys Ser Val Gln Ser Gln Gly Phe Lys Leu Asn 
     50                  55                  60
Val Trp Asp Ile Gly Gly Gln Arg Lys Ile Arg Pro Tyr Trp Arg Ser 
 65                  70                  75                  80
Tyr Phe Glu Asn Thr Asp Ile Leu Ile Tyr Val Ile Asp Ser Ala Asp 
                 85                  90                  95
Arg Lys Arg Phe Glu Glu Thr Gly Gln Glu Leu Thr Glu Leu Leu Glu 
             100                105                110
Glu Glu Lys Leu Ser Cys Val Pro Val Leu Val Phe Ala Asn Lys Gln 
         115                120                125
Asp Leu Leu Thr Ala Ala Pro Ala Ala Glu Ile Ala Glu Gly Leu Asn 
     130                135                140
Leu His Thr Ile Arg Asp Arg Val Trp Gln Ile Gln Ser Cys Ser Ala 
 145                150                155                160
Leu Thr Gly Glu Gly Val Gln Asp Gly Met Asn Trp Val Cys Lys Asn 
                 165                170                175
Val Asn Ala Lys Lys Lys 
             180



<210> 8108
<211> 870
<212> DNA
<213> Homo sapiens
<308> BC009841
<400> 8108

ggcacgagg  tggtaacgg  ggaggcagc  ggaggagga  gaggaggag  gactcggcg  60
gaggatggg  ttgctctca  ttttgcgca  gttgaaaag  gcaccagac  aggaggtga  120
aatacttct  ctgggcttg  ataatgctg  caagaccac  cttctgaag  agcttgcat  180
tgaagacat  agccacatc  cacctacac  gggtttcaa  atcaaaagt  tacaatcac  240
aggttttaa  ctgaatgta  gggacattg  tggacagag  aaaatcaga  catactgga  300
gaattattt  gaaaatacc  atattctta  atatgtaat  gacagtgca  acagaaaaa  360
atttgaaga  acgggtcag  aactagcgg  attactgga  gaagaaaaa  taagttgtg  420
gccagtgct  atctttgct  ataagcagg  tttgctcac  gcagcccct  cctctgaaa  480
tgcagaagg  ctgaacctg  ataccatcc  cgaccgagt  tggcagatc  agtcttgct  540
agctctcac  ggagagggc  ttcaggatg  catgaactg  gtctgcaaa  atgtcaatg  600
aaagaagaa  taaaatcta  acgaatgga  atgcaggag  tgcgggagc  gaattcggt  660
ctgaaaaac  ctaatttgc  gctttctga  caaatgttt  tccatctgt  tacagctcc  720
gctgtttga  gagagggaa  aacatggtt  agaaagaat  cccattcca  cagtagatt  780
aactgatct  tgaggttca  tatcatttt  caaataaag  aattatatt  tttcctctg  840
ataaaaaaa  aaaaaaaaa  aaaaaaaaaa  870



<210> 8109
<211> 182
<212> PRT
<213> Homo sapiens
<308> P36405
<400> 8109

Met Gly Leu Leu Ser Ile Leu Arg Lys Leu Lys Ser Ala Pro Asp Gln 
  1               5                  10                  15
Glu Val Arg Ile Leu Leu Leu Gly Leu Asp Asn Ala Gly Lys Thr Thr 
             20                  25                  30
Leu Leu Lys Gln Leu Ala Ser Glu Asp Ile Ser His Ile Thr Pro Thr 
         35                  40                  45
Gln Gly Phe Asn Ile Lys Ser Val Gln Ser Gln Gly Phe Lys Leu Asn 
     50                  55                  60
Val Trp Asp Ile Gly Gly Gln Arg Lys Ile Arg Pro Tyr Trp Lys Asn 
 65                  70                  75                  80
Tyr Phe Glu Asn Thr Asp Ile Leu Ile Tyr Val Ile Asp Ser Ala Asp 
                 85                  90                  95
Arg Lys Arg Phe Glu Glu Thr Gly Gln Glu Leu Ala Glu Leu Leu Glu 
             100                105                110
Glu Glu Lys Leu Ser Cys Val Pro Val Leu Ile Phe Ala Asn Lys Gln 
         115                120                125
Asp Leu Leu Thr Ala Ala Pro Ala Ser Glu Ile Ala Glu Gly Leu Asn 
     130                135                140
Leu His Thr Ile Arg Asp Arg Val Trp Gln Ile Gln Ser Cys Ser Ala 
 145                150                155                160
Leu Thr Gly Glu Gly Val Gln Asp Gly Met Asn Trp Val Cys Lys Asn 
                 165                170                175
Val Asn Ala Lys Lys Lys 
             180



<210> 8110
<211> 915
<212> DNA
<213> Rattus norvegicus
<308> U13176
<400> 8110

aattccgcg  cggcccctt  cccgtccct  ccccgtccc  gtccccgcc  ggccagccg  60
caccgtttc  caccatggc  ctgaagaga  tccacaagg  attgaatga  ctggctcga  120
atcctccag  acagtgttc  gcaggtcct  ttggagatg  tatgtttca  tggcaggct  180
caataatgg  gccaaatga  agcccctat  agggtggag  atttttctt  actattcat  240
tcccaacag  ttacccctt  aaaccgcct  aggttgcat  tacaacaag  atttatcat  300
caaatatta  cagtaatgg  agcatttgt  ttgatattc  acggtcaca  tggtctcca  360
cactaacta  ttcaaaagt  cttttgtcc  tctgttctc  gttgtgtga  cccaatcca  420
atgatcctt  agtgcctga  attgctcgg  tctacaaaa  agatagaga  aagtacaac  480
gaatagctc  ggaatggac  cagaagtat  ccatgtaat  aaagaaatt  ttggataac  540
tctacaaat  aagctagga  aactctgaa  gagagaaag  ccttttgat  tccatttga  600
tgctttcta  gagcccacc  cctcatctt  ccctgtgca  atgtttacc  gacacagca  660
tgctgcgtt  ttgtacata  ttggaacaa  aaactagaa  tactgtact  ctgtaccaa  720
attgcctcc  agcagagaa  tgtgtgtgt  agaagccag  tctccgggc  taacctagg  780
ctatttcga  gtaagggtg  acattcatt  gatggaaac  cttgtgtat  tttaaagac  840
cagtgcttc  tctggagct  gtacgttca  gaatgatta  tctgtgtaa  aaactgatt  900
ctacagtca  tacgg  915



<210> 8111
<211> 147
<212> PRT
<213> Rattus norvegicus
<308> P51669
<400> 8111

Met Ala Leu Lys Arg Ile His Lys Glu Leu Asn Asp Leu Ala Arg Asp 
  1               5                  10                  15
Pro Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Met Phe His 
             20                  25                  30
Trp Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly 
         35                  40                  45
Val Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
     50                  55                  60
Pro Lys Val Ala Phe Thr Thr Arg Ile Tyr His Pro Asn Ile Asn Ser 
 65                  70                  75                  80
Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                 85                  90                  95
Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
             100                105                110
Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Arg Ile Tyr Lys 
         115                120                125
Thr Asp Arg Glu Lys Tyr Asn Arg Ile Ala Arg Glu Trp Thr Gln Lys 
     130                135                140
Tyr Ala Met 
 145



<210> 8112
<211> 2011
<212> DNA
<213> Homo sapiens
<308> AF317220
<400> 8112

cccggtcct  ttggagatg  tatgttcca  tggcaagct  caataatgg  gccaaatga  60
agtccctat  agggtggag  atttttctt  acaattcat  tcccaacag  ttacccctt  120
aaaccacct  aggttgcat  tacaacaag  atttatcat  caaatatta  cagtaatgg  180
agcatttgt  ttgatattc  acgatcaca  tggtctcca  cactaacta  ttcaaaagt  240
ctcttgtcc  tctgttctc  gttgtgtga  cccaatcca  atgatcctt  agtgcctga  300
attgctcgg  tctacaaaa  agatagaga  aagtacaac  gaatagctc  ggaatggac  360
cagaagtat  cgatgtaat  aaagaaatt  ttggataac  tctacaaat  aagataggg  420
aactctgaa  gagaaagtc  ttttgattt  catttgact  ctttctatg  gcccacgcc  480
catcttccc  tgtgcacat  tttacctga  acagcagtg  tgcgtgttg  acatacttg  540
aacaacaaa  tagaaatac  gtacttctg  accaacatt  cctcctagc  gagaagtgt  600
tgtgtgaca  gccagttct  caggcatta  ctaggtgtg  gactaaaag  ttttcttat  660
gacttaaat  tggataaca  caaggtgtg  ggggggtgg  gggtatggt  tgtgcttgg  720
tgggaaaga  aaggctcca  tcacctata  gagattatt  ttaagtgga  tccatttaa  780
ctcaaaaca  ttatgaaaa  caaggtgaa  aacatgaag  tgtgtctgt  ttcatttta  840
tccgaagga  ctacgtctt  ggtgaaagt  atgaccaac  agattaaac  ctacccaca  900
cctgcattt  aaggtctaa  tttaactgg  caacattta  atggattgg  gctattagt  960
catcaagtg  gatgggctt  gttcccaac  cttttacat  tccctaccc  ttcaacctt  1020
ggcctttca  cccttcttt  tctcttcca  attctttgg  ttgtatgtg  tttctcagt  1080
aatacatag  taatagctc  tatttttct  atgttttta  ccgcttagg  ctatttgga  1140
gtaagggtg  aaattcatt  gatggaaat  cttgtgtat  tttaaagac  caattgctc  1200
tctggagct  gtactttca  gaatgatta  tctgtgtaa  aaactggtt  ctacagtca  1260
tacatataa  tttgtgtga  taggctttt  catttttaa  aagttgtta  taaataggg  1320
gattttttc  ccttttgaa  gttcattaa  ggggcattt  taagatcat  aaacaattc  1380
agttacatt  taaaaagga  atcttacga  taattttat  gaacaagtt  gaggcataa  1440
cttaagagc  tttccatga  acaacacat  cagcattcc  ggaacttga  tgttaaatt  1500
aataagaaa  ttgctttat  aatgaaact  agctgcatt  catcaaaac  ttgtgacat  1560
cccttggta  ataggacat  aaacacaga  gcattgcta  ttggtaagt  aagcttctg  1620
gattgtaat  ataaaagag  aacattgac  aaacctggg  aacaagagc  cagtcttgt  1680
tggagagtc  acataatta  tttgcacta  catttgcag  atgttcaca  aattttaaa  1740
tgtactgta  gtggctttt  gaagtcttc  cttgaccct  gtaaaatat  gcttgaaac  1800
tgtaaacaa  tgtgtttgc  agaaacatc  ttcatgtga  ctaggcaag  taccttttt  1860
ccccccttc  tttcctaat  gtaaactag  ccaacctga  agccatggc  gatgctcta  1920
ccatcaggt  ctttcaaat  catctttac  ctcttgcac  aaagttaag  aataaatgt  1980
cactgcttt  ggttttaaa  aaaaaaaaa  a  2011



<210> 8113
<211> 147
<212> PRT
<213> Homo sapiens
<308> P51669
<400> 8113

Met Ala Leu Lys Arg Ile His Lys Glu Leu Asn Asp Leu Ala Arg Asp 
  1               5                  10                  15
Pro Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Met Phe His 
             20                  25                  30
Trp Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly 
         35                  40                  45
Val Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
     50                  55                  60
Pro Lys Val Ala Phe Thr Thr Arg Ile Tyr His Pro Asn Ile Asn Ser 
 65                  70                  75                  80
Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                 85                  90                  95
Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
             100                105                110
Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Arg Ile Tyr Lys 
         115                120                125
Thr Asp Arg Glu Lys Tyr Asn Arg Ile Ala Arg Glu Trp Thr Gln Lys 
     130                135                140
Tyr Ala Met 
 145



<210> 8114
<211> 901
<212> DNA
<213> Rattus norvegicus
<308> U13177
<400> 8114

tccgatgcc  tttcaggtc  ggaatcagc  gggtcctct  agccttggc  gtgctgatc  60
gctcgtttg  aaaggcgcc  gtgtctcag  gccggtgtg  gaagaagag  gaatccttc  120
cgccgccgg  agtaatcaa  agttttggc  ggacctttg  gtacacatc  ggatagtga  180
aagcccggc  aaaagcaca  actatggcg  tgaaacgga  taataagga  cttagtgat  240
tggcccgtg  ccctccagc  caatgttct  caggtccag  tggagatga  atgtttcat  300
ggcaagcca  aattatggg  cctaatgac  gcccatatc  aggtggtgt  ttctttttg  360
caattcatt  tcctacaga  taccccttc  aaccaccta  ggttgcatt  acaacaaga  420
tttatcatc  aaatattaa  agtaatggc  gcatttgtc  tgatattct  agatcacag  480
ggtctcctg  tttaactat  tctaaagtt  ttttatcca  ttgttcact  ctatgtgat  540
caaacccag  tgaccccct  gtgccagag  ttgcacgga  ctataaaac  gacagagac  600
agtacaaca  aatatctcg  gaatggact  agaagtatg  catgtgatg  taccttaaa  660
tcagaataa  ctgcattat  gctggaata  actttaaat  acttttgag  tttataatc  720
ttattgagc  tctgttaca  aaggggtgt  acatttgcc  ttatggtga  ttagtctgg  780
tgcgtgttc  cagcccgaa  gagaagtaa  atcttaaca  agcacagaa  agaaaggac  840
ttggggatc  cttagccca  cccattatt  tcatggagg  aatgaaacc  aagaaagga  900
a  901



<210> 8115
<211> 147
<212> PRT
<213> Rattus norvegicus
<308> P47986
<400> 8115

Met Ala Leu Lys Arg Ile Asn Lys Glu Leu Ser Asp Leu Ala Arg Asp 
  1               5                  10                  15
Pro Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Met Phe His 
             20                  25                  30
Trp Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly 
         35                  40                  45
Val Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
     50                  55                  60
Pro Lys Val Ala Phe Thr Thr Arg Ile Tyr His Pro Asn Ile Asn Ser 
 65                  70                  75                  80
Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                 85                  90                  95
Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
             100                105                110
Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Arg Ile Tyr Lys 
         115                120                125
Thr Asp Arg Asp Lys Tyr Asn Arg Ile Ser Arg Glu Trp Thr Gln Lys 
     130                135                140
Tyr Ala Met 
 145



<210> 8116
<211> 724
<212> DNA
<213> Homo sapiens
<308> U39318
<400> 8116

gagcataca  cgagagagt  aggagccag  cgacaagca  acactatgg  gctgaaacg  60
attaataag  aacttagtg  tttggcccg  gaccctcca  cacaatgtt  tgcaggtcc  120
gttggggat  atatgtttc  ttggcaagc  acaattatg  gacctaatg  cagcccata  180
caaggcggt  tattctttt  gacaattca  tttcctaca  actacccct  caaaccacc  240
aaggttgca  ttacaacaa  aatttatca  ccaaatatt  acagtaatg  cagcatttg  300
ctcgatatt  taagatcac  gtggtcgcc  gctttaaca  tttctaaag  tcttttatc  360
atttgttca  tgctatgtg  tccaaaccc  gatgacccc  tagtgccag  gattgcacg  420
atctataaa  cagacagag  taagtacaa  agaatatct  gggaatgga  tcagaagta  480
gccatgtga  gctacctta  agtcagaat  acctgcatt  tagctggaa  aaactttaa  540
ttactgttc  ttttttgat  ttcttatcc  gctgctccc  tgatcagac  tcatctttt  600
taattttat  ttttgttta  ctccctcca  tcattcaca  gctcatctg  gaagactta  660
gttcttcca  ctttgacaa  aactgcttt  agaaactgt  aagtagtta  aagagaaca  720
ttgg  724



<210> 8117
<211> 147
<212> PRT
<213> Homo sapiens
<308> P47986
<400> 8117

Met Ala Leu Lys Arg Ile Asn Lys Glu Leu Ser Asp Leu Ala Arg Asp 
  1               5                  10                  15
Pro Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Met Phe His 
             20                  25                  30
Trp Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly 
         35                  40                  45
Val Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
     50                  55                  60
Pro Lys Val Ala Phe Thr Thr Arg Ile Tyr His Pro Asn Ile Asn Ser 
 65                  70                  75                  80
Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                 85                  90                  95
Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
             100                105                110
Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Arg Ile Tyr Lys 
         115                120                125
Thr Asp Arg Asp Lys Tyr Asn Arg Ile Ser Arg Glu Trp Thr Gln Lys 
     130                135                140
Tyr Ala Met 
 145



<210> 8118
<211> 429
<212> DNA
<213> Rattus norvegicus
<308> U13895
<400> 8118

aagaggatg  gaaggacga  aagcccatc  gagctctgg  tgaagggga  atcgccttg  60
tgaaaactt  tggccagag  acttattcg  ggcagatca  gcaggttga  gatgacatt  120
agcaacttc  taaaaaaat  aatgagctc  ctggtatca  agagtccga  actgggctg  180
cccctccag  actctggga  ttggctgca  acaaacaga  acttcagag  gaacagcct  240
tacaggttg  aagatgtac  aagataatc  acgccgatt  agaggaccc  aaatacatc  300
tcaacgtga  gcagtttgc  aagttcgtg  tggatctca  tgatcaggt  gcacctact  360
acattgagg  agggatgag  gtcggcgtg  acagaaata  ataccaaat  cacattcca  420
tgcctccta  429



<210> 8119
<211> 142
<212> PRT
<213> Rattus norvegicus
<308> AAC53589
<400> 8119

Glu Asp Glu Lys Asp Asp Lys Pro Ile Arg Ala Leu Asp Glu Gly Asp 
  1               5                  10                  15
Ile Ala Leu Leu Lys Thr Tyr Gly Gln Ser Thr Tyr Ser Arg Gln Ile 
             20                  25                  30
Lys Gln Val Glu Asp Asp Ile Gln Gln Leu Leu Lys Lys Ile Asn Glu 
         35                  40                  45
Leu Thr Gly Ile Lys Glu Ser Asp Thr Gly Leu Ala Pro Pro Ala Leu 
     50                  55                  60
Trp Asp Leu Ala Ala Asp Lys Gln Thr Leu Gln Ser Glu Gln Pro Leu 
 65                  70                  75                  80
Gln Val Ala Arg Cys Thr Lys Ile Ile Asn Ala Asp Ser Glu Asp Pro 
                 85                  90                  95
Lys Tyr Ile Ile Asn Val Lys Gln Phe Ala Lys Phe Val Val Asp Leu 
             100                105                110
Ser Asp Gln Val Ala Pro Thr Asp Ile Glu Glu Gly Met Arg Val Gly 
         115                120                125
Val Asp Arg Asn Lys Tyr Gln Ile His Ile Pro Leu Pro Pro 
     130                135                140



<210> 8120
<211> 1478
<212> DNA
<213> Homo sapiens
<308> NM_002803
<400> 8120

ccattgtgc  ctaaaggga  ggtgctgtg  aatcattaa  gagcggagg  ttttggagc  60
gctaaaatg  cggattacc  cggtgccga  cagcggaag  ccaaagagg  tgagaagga  120
gacaagccc  tccgagctc  ggatgaggg  gatattgcc  tgttgaaaa  ttatggtca  180
agcacttac  ctaggcaga  caagcaagt  gaagatgac  ttcagcaac  tctcaagaa  240
attaatgag  tcactggta  taaagaatc  gacactggc  tggccccac  agcactctg  300
gatttggct  cagataagc  gacactcca  agtgaacag  ctttacagg  tgccaggtg  360
acaaagata  tcaatgctg  ttcggagga  ccaaaatac  ttatcaacg  aaagcagtt  420
gccaagttt  tggtggacc  tagtgatca  gtggcacct  ctgacattg  agaagggat  480
agagtgggc  tggatagaa  taaatatca  attcacatt  cattgcctc  taagattga  540
ccaacagtt  ccatgatgc  ggtggaaga  aaacctgat  tcacataca  tgatgttgg  600
ggctgtaag  aacagattg  gaaactgcg  gaagtagtt  aaaccccat  acttcatcc  660
gagaggttt  tgaaccttg  cattgagcc  cccaagggc  tgctgctct  tggtccacc  720
ggtacaggc  agacactct  tgcgcgggc  gttgctaat  ggactgatg  gtgcttcat  780
cgagttatt  gatctgagc  tgtacagaa  tacgtcggt  agggggctc  aatggttcg  840
gaactcttt  aaatggcca  aacaaaaaa  gcctgcctt  tcttctttg  tgaaattga  900
gctattgga  gggctcgtt  tgatgatgg  gctggaggt  acaatgaag  gcagagaac  960
atgttggaa  tgatcaatc  gcttgatgg  tttgatcct  gaggcaata  taaagtgct  1020
atggccact  acagacctg  tactttgga  ccagcactg  tgaggccag  gagattgga  1080
agaaaaatt  aatttagct  gcccgatct  gagggtcgg  cccacatat  taagattca  1140
gctcgttca  tgagtgttg  aagagatat  agatttgaa  tgttagcac  actgtgtcc  1200
aatagcact  gtgctgaga  tagaagcgt  tgcacagag  ctggtatgt  tgccatcag  1260
gcacggcga  aaattgcta  cgagaagga  ttcttggaa  ctgtaaata  ggtcattaa  1320
tcttatgcc  aattcagtg  tactcctcg  tacatgaca  acaactgaa  cctgaaggc  1380
ttcaagtga  aactttaaa  tggaatcct  accttatat  gacttgtta  taaccaatt  1440
ataaacaaa  aaatggctt  aactttaga  cacaatgg  1478



<210> 8121
<211> 433
<212> PRT
<213> Homo sapiens
<308> P35998
<400> 8121

Met Pro Asp Tyr Leu Gly Ala Asp Gln Arg Lys Thr Lys Glu Asp Glu 
  1               5                  10                  15
Lys Asp Asp Lys Pro Ile Arg Ala Leu Asp Glu Gly Asp Ile Ala Leu 
             20                  25                  30
Leu Lys Thr Tyr Gly Gln Ser Thr Tyr Ser Arg Gln Ile Lys Gln Val 
         35                  40                  45
Glu Asp Asp Ile Gln Gln Leu Leu Lys Lys Ile Asn Glu Leu Thr Gly 
     50                  55                  60
Ile Lys Glu Ser Asp Thr Gly Leu Ala Pro Pro Ala Leu Trp Asp Leu 
 65                  70                  75                  80
Ala Ala Asp Lys Gln Thr Leu Gln Ser Glu Gln Pro Leu Gln Val Ala 
                 85                  90                  95
Arg Cys Thr Lys Ile Ile Asn Ala Asp Ser Glu Asp Pro Lys Tyr Ile 
             100                105                110
Ile Asn Val Lys Gln Phe Ala Lys Phe Val Val Asp Leu Ser Asp Gln 
         115                120                125
Val Ala Pro Thr Asp Ile Glu Glu Gly Met Arg Val Gly Val Asp Arg 
     130                135                140
Asn Lys Tyr Gln Ile His Ile Pro Leu Pro Pro Lys Ile Asp Pro Thr 
 145                150                155                160
Val Thr Met Met Gln Val Glu Glu Lys Pro Asp Val Thr Tyr Ser Asp 
                 165                170                175
Val Gly Gly Cys Lys Glu Gln Ile Glu Lys Leu Arg Glu Val Val Glu 
             180                185                190
Thr Pro Leu Leu His Pro Glu Arg Phe Val Asn Leu Gly Ile Glu Pro 
         195                200                205
Pro Lys Gly Val Leu Leu Phe Gly Pro Pro Gly Thr Gly Lys Thr Leu 
     210                215                220
Cys Ala Arg Ala Val Ala Asn Arg Thr Asp Ala Cys Phe Ile Arg Val 
 225                230                235                240
Ile Gly Ser Glu Leu Val Gln Lys Tyr Val Gly Glu Gly Ala Arg Met 
                 245                250                255
Val Arg Glu Leu Phe Glu Met Ala Arg Thr Lys Lys Ala Cys Leu Ile 
             260                265                270
Phe Phe Asp Glu Ile Asp Ala Ile Gly Gly Ala Arg Phe Asp Asp Gly 
         275                280                285
Ala Gly Gly Asp Asn Glu Val Gln Arg Thr Met Leu Glu Leu Ile Asn 
     290                295                300
Gln Leu Asp Gly Phe Asp Pro Arg Gly Asn Ile Lys Val Leu Met Ala 
 305                310                315                320
Thr Asn Arg Pro Asp Thr Leu Asp Pro Ala Leu Met Arg Pro Gly Arg 
                 325                330                335
Leu Asp Arg Lys Ile Glu Phe Ser Leu Pro Asp Leu Glu Gly Arg Thr 
             340                345                350
His Ile Phe Lys Ile His Ala Arg Ser Met Ser Val Glu Arg Asp Ile 
         355                360                365
Arg Phe Glu Leu Leu Ala Arg Leu Cys Pro Asn Ser Thr Gly Ala Glu 
     370                375                380
Ile Arg Ser Val Cys Thr Glu Ala Gly Met Phe Ala Ile Arg Ala Arg 
 385                390                395                400
Arg Lys Ile Ala Thr Glu Lys Asp Phe Leu Glu Ala Val Asn Lys Val 
                 405                410                415
Ile Lys Ser Tyr Ala Lys Phe Ser Ala Thr Pro Arg Tyr Met Thr Tyr 
             420                425                430
Asn 
         435



<210> 8122
<211> 4056
<212> DNA
<213> Rattus norvegicus
<308> U14005
<400> 8122

ggatccccc  tgcaacaat  agagatgct  agtgtgtcg  ctttgagca  ggagtacct  60
cccagaaac  tttattttc  taattcacg  tgagccttt  gctttaaag  cgctgttct  120
aaacgttct  aaactcagt  ggaacaagc  gatccgaac  aaggcaaat  aatcgaatc  180
tgcaaagta  caaagcaga  gccttttcc  aacagccag  acaaagcta  atgaaaaat  240
tcagtcatc  actagatac  gtatttccc  cactagaca  gagctgggg  ctgtagatc  300
cccctcccc  aaacaggag  ccgagaagg  acaaaacaa  gtattcatt  ctaaacgag  360
catcacttc  agctgcacc  tctacctct  cgcactcgc  gtttgaaag  cctcggctg  420
tacttctct  tacctgcct  caaacacac  tggaggtgg  ggcgagagg  agggagccc  480
ccgccacgt  tgcataagg  gagggagga  gggattggg  ctgagggca  ttccctgag  540
acagttagt  ctgcctaaa  tgcaaggct  ccccattcc  ctgtacccc  aaactggag  600
aaacagtgt  ggggcctgg  gacgcctgt  cacggtcca  gcagagccc  ggaaccctg  660
gctttgatg  tgcagcagc  atcgcctgt  ggcacctgg  tttctgggg  gcggggcct  720
ccccaggtg  gcggagagc  aaggccacc  gagccagcc  agaggaccc  aggagcctc  780
tccggggga  acggtacaa  agagcggct  gtcggtgcc  ccagcagca  gcaccgggc  840
ccacgggcc  ggctccggg  aggggcgcc  gcgcggcgg  accgagggg  ttaaccggg  900
ggcccgcgg  cgnagcgcg  ttaaccctc  gtcagccgc  ccagcccgg  ggtggcggc  960
tccgagtcg  gcgccgtgg  gcccggggg  cgcgtgggc  gcaggccgg  agctggggc  1020
cggcgcggc  ggtgggagg  ccgggcgcg  gggggaggg  gggggacgg  ggcggcggg  1080
gcgcagcgt  gccaggacg  anccggcgt  cagcgcggc  cggcgggcg  ggagcgggc  1140
ggcgggcgg  cgagcgcct  cgtccccgg  tgtgagctc  ggctgcccg  ggtcccgag  1200
cagcggcgg  gcgggcggc  acggcggcg  cggggcacc  ggcaccggg  cgggcgggc  1260
gacgggcgg  atggggggc  cgtcgagcg  ccccggcgg  cgggcgggc  ccaccgcgg  1320
gtccctccg  tagaggagg  gaccaagcc  attctcctt  gcagcaaaa  aagagaaaa  1380
agaaaaaaa  gaaaaattt  cttgtatat  ttactaaga  aatatatac  tctgatttt  1440
ttttttaca  aaagtttat  ttgctccat  tttcaaaaa  agaaggagc  tgggtggca  1500
gcggttttt  taaattatt  ttattttga  tatttgtct  tgtccttcc  caccccctg  1560
tgaagcgaa  atagggcag  gaccgcggc  cctacctat  agtaacctc  catacccgt  1620
cctccccct  cctaacgct  agcatagtg  cctgcacac  gtaggcgct  aataaatgt  1680
cgtggatga  gatgatgat  atgatgaaa  aaatgcagc  tcaacggca  cagcaagag  1740
accacgcga  cggtgagca  ccagagccc  ggtacccgc  gccaaacct  atcctatca  1800
gatcctact  ttcccactc  ccaaccccc  tctccgatg  gttgggtgg  ttgaggggg  1860
tggagatga  gcttttggc  tggtgtcat  tacatagaa  ggggtgatg  gcggcagct  1920
cttcgttct  ctcttcagg  cctgaatgt  agagttaat  ctgcatttg  tggggtggg  1980
cggccattg  gtgtgtgga  tactgtgca  ccaaggggc  agagtgagg  gattcgggt  2040
caagtgccc  cgggctcaa  ttttctctt  cattgcccc  gagcgatgg  agaggtgtt  2100
gtcttcagc  tgaacccct  ttccagcct  cccccccac  cccacgcct  tggttgact  2160
agaggaagg  ctttagtag  atcaggaaa  ttctaggat  gctccgctt  tactcgttg  2220
gtcacttgg  aaagtgcac  tccatcatc  catgggaga  gccccccgg  cttgggatc  2280
gggggaaca  ggtcaggtg  agcgagtat  cccgctcgc  ccctgtgcc  cctgtgcac  2340
cgtcgtcgg  aacctagca  tgcccagag  gttgctgcc  ctgtggggc  ctgcaactc  2400
gccctggcc  tggcaccac  tgcagtttc  acaccagcg  ggctgggtc  gagaaggtt  2460
ggttgcttt  ggctaggtt  cctccgtgg  ggtcgttgg  atctcccaa  cctgttttc  2520
tgaagcctt  tccggtgag  acttctcaa  gggaaagct  ggcaaaatt  gttcctgat  2580
tcagattga  tgccacctg  ctgctttgc  gctgtccca  gctcatagg  cagtggggc  2640
ggagacctg  gcttgcttt  actctttgc  tagtgataa  tagctttgc  aacgcctgg  2700
tctccaacc  ctctccacc  ttctcactt  gacatctgc  tcagcagag  tgatgatgg  2760
ggcccaacg  gggcacctg  gagaccgtc  gagggatgg  cagacccat  gtgaggcgg  2820
ctccgcaca  gaagagacc  gaccccccc  ccccccccc  cgccccacc  ttgagtatt  2880
tgccttgtg  gtacctgga  gctactcta  gccgagata  ttcttgaat  ggccttgag  2940
ttccctggc  taacgcacc  tgtctctta  gtgtagggg  gcaggctgg  ttggctgct  3000
ctgctgcaa  taaaaaaaa  aaaaaagcc  taaagatgt  tttctgttt  cggaagctt  3060
tggaggaaa  gagtcccaa  caccatgaa  tttcatttg  aggaagtgt  agtgcataa  3120
ctagatatt  gttatgggg  ttttgctat  gcctggtgc  agtgaggag  ttgtttttt  3180
tttcttcta  gtagaaaaa  tgcatttat  gctgtggag  gctgttgga  ggacaccct  3240
aaaatggtt  agactgttg  atttattgg  tctgtgtgt  tgtgtgtgt  tgtgtgtgt  3300
tgtgtgttg  taataaatt  tagagaaag  cagctgtat  gatgtatct  ttaagccat  3360
agagatacg  gtgttttca  agtcaggaa  agacacagg  taaattcga  aatagcccc  3420
gtttgtcag  agagaggca  tcatggctt  cctttgaag  cacaggtat  ggagagtac  3480
agtgtggct  ggtgtggtg  agcaacgca  gtctagtgc  cagggcaga  ctctgctga  3540
ttctgcatt  cctggccaa  ccccactac  tgtgacaca  ggttcaaaa  gggaaacac  3600
agatgggag  cacttttgc  tttttaaaa  gatagtata  atcaaggtc  ttctttttt  3660
tttttttct  ccccaaaga  aaataatct  ttttctcct  ctcctcaga  gcaaactat  3720
caagaggca  cagactccc  atttctggt  aaggaccaa  ttctcagcc  aacagctcc  3780
agcaaaccg  cctgtcttg  caagctgca  ttgatgctg  tagacaggc  aaggccgcc  3840
agaccatga  cacgtctgc  cccccacct  taggatctc  ctcccaaag  aaacgtcag  3900
aatacgcca  gagcaaaaa  cagggtaac  cgtctaaca  ccgacctgc  cgtgccctc  3960
tctgtttat  cctcaataa  cccatccga  gagcctgca  tagtatagt  gattggaag  4020
atccttttt  tgtgggaaa  tctttcaaa  ggatcc  4056



<210> 8123
<211> 2203
<212> PRT
<213> Rattus norvegicus
<308> AAB60515
<400> 8123

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
  1               5                  10                  15
Gln Glu Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
             20                  25                  30
Pro Ile Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
         35                  40                  45
Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
     50                  55                  60
Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
 65                  70                  75                  80
Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                 85                  90                  95
Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
             100                105                110
Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Asp Trp Lys Pro Phe 
         115                120                125
Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
     130                135                140
Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
 145                150                155                160
Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                 165                170                175
Phe Leu Lys Ile Ile Ala Ser Gly Leu Leu Leu His Pro Asn Ala Ser 
             180                185                190
Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
         195                200                205
Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
     210                215                220
Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
 225                230                235                240
Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                 245                250                255
Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
             260                265                270
His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
         275                280                285
Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
     290                295                300
Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
 305                310                315                320
Gly Asn Gly Arg Gln Cys Ala Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                 325                330                335
Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
             340                345                350
Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
         355                360                365
Val Leu Tyr Trp Val Asn Asp Ala Ile Gly Trp Glu Trp Pro Trp Val 
     370                375                380
Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser Phe Phe Val Leu Asn Leu 
 385                390                395                400
Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                 405                410                415
Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
             420                425                430
Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
         435                440                445
Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
     450                455                460
Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
 465                470                475                480
Gly Glu Gly Glu Thr Gln Gly Cys Cys Gly Ser Leu Trp Cys Trp Trp 
                 485                490                495
Lys Arg Arg Gly Ala Ala Lys Thr Gly Pro Ser Gly Cys Arg Arg Trp 
             500                505                510
Gly Gln Ala Ile Ser Lys Ser Lys Leu Arg Ser His Gly Ala Arg Glu 
         515                520                525
Ala Leu Cys Val Cys Arg Cys Ser Leu Glu Ser Leu Val Lys Leu Trp 
     530                535                540
Thr Ser Arg Phe Ser Ala His Leu Gln Ala Ala Tyr Val Arg Pro Tyr 
 545                550                555                560
Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn Arg Arg Arg Cys Arg 
                 565                570                575
Ala Ala Val Lys Ser Val Thr Phe Tyr Trp Leu Val Ile Val Leu Val 
             580                585                590
Phe Leu Asn Thr Leu Thr Ile Ser Ser Glu His Tyr Asn Gln Pro Asp 
         595                600                605
Trp Leu Thr Gln Ile Gln Asp Ile Ala Asn Lys Val Leu Leu Ala Leu 
     610                615                620
Phe Thr Cys Glu Met Leu Val Lys Met Tyr Ser Leu Gly Leu Gln Ala 
 625                630                635                640
Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly 
                 645                650                655
Gly Ile Thr Glu Thr Ile Leu Val Glu Leu Glu Leu Met Ser Pro Leu 
             660                665                670
Gly Val Ser Val Phe Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val 
         675                680                685
Thr Arg His Trp Thr Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn 
     690                695                700
Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile 
 705                710                715                720
Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn 
                 725                730                735
Phe Asp Glu Thr Gln Thr Lys Arg Ser Thr Phe Asp Asn Phe Pro Gln 
             740                745                750
Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Ala 
         755                760                765
Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly Pro Ser Ser Ser Gly 
     770                775                780
Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr 
 785                790                795                800
Ile Leu Leu Lys Leu Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asp 
                 805                810                815
Ala Glu Ser Leu Asn Thr Ala Gln Lys Glu Glu Ala Glu Glu Lys Glu 
             820                825                830
Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu Asn Lys Lys Asn Asn 
         835                840                845
Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp Asn Lys Val Thr Ile 
     850                855                860
Asp Asp Tyr Gln Glu Glu Ala Glu Asp Lys Asp Pro Tyr Pro Pro Cys 
 865                870                875                880
Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Pro 
                 885                890                895
Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile Ser Glu Leu Asn Met 
             900                905                910
Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser Ala Phe Phe Ile Leu 
         915                920                925
Ser Lys Thr Asn Pro Ile Arg Val Gly Cys His Lys Leu Ile Asn His 
     930                935                940
His Ile Phe Thr Asn Leu Ile Leu Val Phe Ile Met Leu Ser Ser Ala 
 945                950                955                960
Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His Ser Phe Arg Asn Thr 
                 965                970                975
Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr Ala Ile Phe Thr Val Glu 
             980                985                990
Ile Leu Leu Lys Met Thr Thr Phe Gly Ala Phe Leu His Lys Gly Ala 
         995                1000                1005
Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met Leu Val Val Gly Val 
     1010                1015                1020
Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala Ile Ser Val Val Lys 
 1025                1030                1035                1040
Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg 
                 1045                1050                1055
Ala Lys Gly Leu Lys His Val Val Gln Cys Val Phe Val Ala Ile Arg 
             1060                1065                1070
Thr Ile Gly Asn Ile Met Ile Val Thr Thr Leu Leu Gln Phe Met Phe 
         1075                1080                1085
Ala Cys Ile Gly Val Gln Leu Phe Lys Gly Lys Phe Tyr Arg Cys Thr 
     1090                1095                1100
Asp Glu Ala Lys Ser Asn Pro Glu Glu Cys Arg Gly Leu Phe Ile Leu 
 1105                1110                1115                1120
Tyr Lys Asp Gly Asp Val Asp Ser Pro Val Val Arg Glu Arg Ile Trp 
                 1125                1130                1135
Gln Asn Ser Asp Phe Asn Phe Asp Asn Val Leu Ser Ala Met Met Ala 
             1140                1145                1150
Leu Phe Thr Val Ser Thr Phe Glu Gly Trp Pro Ala Leu Leu Tyr Lys 
         1155                1160                1165
Ala Ile Asp Ser Asn Gly Glu Asn Val Gly Pro Val Tyr Asn Tyr Arg 
     1170                1175                1180
Val Glu Ile Ser Ile Phe Phe Ile Ile Tyr Ile Ile Ile Val Ala Phe 
 1185                1190                1195                1200
Phe Met Met Asn Ile Phe Val Gly Phe Val Ile Val Thr Phe Gln Glu 
                 1205                1210                1215
Gln Gly Glu Lys Glu Tyr Lys Asn Cys Glu Leu Asp Lys Asn Gln Arg 
             1220                1225                1230
Gln Cys Val Glu Tyr Ala Leu Lys Ala Arg Pro Leu Arg Arg Tyr Ile 
         1235                1240                1245
Pro Lys Asn Pro Tyr Gln Tyr Lys Phe Trp Tyr Val Val Asn Ser Ser 
     1250                1255                1260
Pro Phe Glu Tyr Met Met Phe Val Leu Ile Met Leu Asn Thr Leu Cys 
 1265                1270                1275                1280
Leu Ala Met Gln His Tyr Glu Gln Ser Lys Met Phe Asn Asp Ala Met 
                 1285                1290                1295
Asp Ile Leu Asn Met Val Phe Thr Gly Val Phe Thr Val Glu Met Val 
             1300                1305                1310
Leu Lys Val Ile Ala Phe Lys Pro Lys Gly Tyr Phe Ser Asp Ala Trp 
         1315                1320                1325
Asn Thr Phe Asp Ser Leu Ile Val Ile Gly Ser Ile Ile Asp Val Ala 
     1330                1335                1340
Leu Ser Glu Ala Asp Asn Ser Glu Glu Ser Asn Arg Ile Ser Ile Thr 
 1345                1350                1355                1360
Phe Phe Arg Leu Phe Arg Val Met Arg Leu Val Lys Leu Leu Ser Arg 
                 1365                1370                1375
Gly Glu Gly Ile Arg Thr Leu Leu Trp Thr Phe Ile Lys Ser Phe Gln 
             1380                1385                1390
Ala Leu Pro Tyr Val Ala Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr 
         1395                1400                1405
Ala Val Ile Gly Met Gln Met Phe Gly Lys Val Ala Met Arg Asp Asn 
     1410                1415                1420
Asn Gln Ile Asn Arg Asn Asn Asn Phe Gln Thr Phe Pro Gln Ala Val 
 1425                1430                1435                1440
Leu Leu Leu Phe Arg Cys Ala Thr Gly Glu Ala Trp Gln Glu Ile Met 
                 1445                1450                1455
Leu Ala Cys Leu Pro Gly Lys Leu Cys Asp Pro Asp Ser Asp Tyr Asn 
             1460                1465                1470
Pro Gly Glu Glu Tyr Thr Cys Gly Ser Asn Phe Ala Ile Val Tyr Phe 
         1475                1480                1485
Ile Ser Phe Tyr Met Leu Cys Ala Phe Leu Ile Ile Asn Leu Phe Val 
     1490                1495                1500
Ala Val Ile Met Asp Asn Phe Asp Tyr Leu Thr Arg Asp Trp Ser Ile 
 1505                1510                1515                1520
Leu Gly Pro His His Leu Asp Glu Phe Lys Arg Ile Trp Ser Glu Tyr 
                 1525                1530                1535
Asp Pro Glu Ala Lys Gly Arg Ile Lys His Leu Asp Val Val Thr Leu 
             1540                1545                1550
Leu Arg Arg Ile Gln Pro Pro Leu Gly Phe Gly Lys Leu Cys Pro His 
         1555                1560                1565
Arg Val Ala Cys Lys Arg Leu Val Ala Met Asn Met Pro Leu Asn Ser 
     1570                1575                1580
Asp Gly Thr Val Met Phe Asn Ala Thr Leu Phe Ala Leu Val Arg Thr 
 1585                1590                1595                1600
Ala Leu Lys Ile Lys Thr Glu Gly Asn Leu Glu Gln Ala Asn Glu Glu 
                 1605                1610                1615
Leu Arg Ala Val Ile Lys Lys Ile Trp Lys Lys Thr Ser Met Lys Leu 
             1620                1625                1630
Leu Asp Gln Val Val Pro Pro Ala Gly Asp Asp Glu Val Thr Val Gly 
         1635                1640                1645
Lys Phe Tyr Ala Thr Phe Leu Ile Gln Asp Tyr Phe Arg Lys Phe Lys 
     1650                1655                1660
Lys Arg Lys Glu Gln Gly Leu Val Gly Lys Tyr Pro Ala Lys Asn Thr 
 1665                1670                1675                1680
Thr Ile Ala Leu Gln Ala Gly Leu Arg Thr Leu His Asp Ile Gly Pro 
                 1685                1690                1695
Glu Ile Arg Arg Ala Ile Ser Cys Asp Leu Gln Asp Asp Glu Pro Glu 
             1700                1705                1710
Asp Ser Lys Pro Glu Glu Glu Asp Val Phe Lys Arg Asn Gly Ala Leu 
         1715                1720                1725
Leu Gly Asn Tyr Val Asn His Val Asn Ser Asp Arg Arg Glu Ser Leu 
     1730                1735                1740
Gln Gln Thr Asn Thr Thr His Arg Pro Leu His Val Gln Arg Pro Ser 
 1745                1750                1755                1760
Ile Pro Pro Ala Ser Asp Thr Glu Lys Pro Leu Phe Pro Pro Ala Gly 
                 1765                1770                1775
Asn Ser Val Cys His Asn His His Asn His Asn Ser Ile Gly Lys Gln 
             1780                1785                1790
Val Pro Thr Ser Thr Asn Ala Asn Leu Asn Asn Ala Asn Met Ser Lys 
         1795                1800                1805
Ala Ala His Gly Lys Arg Pro Ser Ile Gly Asp Leu Glu His Val Ser 
     1810                1815                1820
Glu Asn Gly His Tyr Ser Tyr Lys His Asp Arg Glu Leu Gln Arg Arg 
 1825                1830                1835                1840
Ser Ser Ile Lys Arg Thr Arg Tyr Tyr Glu Thr Tyr Ile Arg Ser Glu 
                 1845                1850                1855
Ser Gly Asp Glu Gln Leu Pro Thr Ile Phe Arg Glu Asp Pro Glu Ile 
             1860                1865                1870
His Gly Tyr Phe Arg Asp Pro Arg Cys Phe Gly Glu Gln Glu Tyr Phe 
         1875                1880                1885
Ser Ser Glu Glu Cys Cys Glu Asp Asp Ser Ser Pro Thr Trp Ser Arg 
     1890                1895                1900
Gln Asn Tyr Ser Tyr Tyr Asn Arg Tyr Pro Gly Ser Ser Met Asp Phe 
 1905                1910                1915                1920
Glu Arg Pro Arg Gly Tyr His His Pro Gln Gly Phe Leu Glu Asp Asp 
                 1925                1930                1935
Asp Ser Pro Ile Gly Tyr Asp Ser Arg Arg Ser Pro Arg Arg Arg Leu 
             1940                1945                1950
Leu Pro Pro Thr Pro Pro Ser His Arg Arg Ser Ser Phe Asn Phe Glu 
         1955                1960                1965
Cys Leu Arg Arg Gln Asn Ser Gln Asp Asp Val Leu Pro Ser Pro Ala 
     1970                1975                1980
Leu Pro His Arg Ala Ala Leu Pro Leu His Leu Met Gln Gln Gln Ile 
 1985                1990                1995                2000
Met Ala Val Ala Gly Leu Asp Ser Ser Lys Ala Gln Lys Tyr Ser Pro 
                 2005                2010                2015
Ser His Ser Thr Arg Ser Trp Ala Thr Pro Pro Ala Thr Pro Pro Tyr 
             2020                2025                2030
Arg Asp Trp Thr Pro Cys Tyr Thr Pro Leu Ile Gln Val Asp Arg Ser 
         2035                2040                2045
Glu Ser Met Asp Gln Val Asn Gly Ser Leu Pro Ser Leu His Arg Ser 
     2050                2055                2060
Ser Trp Tyr Thr Asp Glu Pro Asp Ile Ser Tyr Arg Thr Phe Thr Pro 
 2065                2070                2075                2080
Ala Ser Leu Thr Val Pro Ser Ser Phe Arg Asn Lys Asn Ser Asp Lys 
                 2085                2090                2095
Gln Arg Ser Ala Asp Ser Leu Val Glu Ala Val Leu Ile Ser Glu Gly 
             2100                2105                2110
Leu Gly Arg Tyr Ala Arg Asp Pro Lys Phe Val Ser Ala Thr Lys His 
         2115                2120                2125
Glu Ile Ala Asp Ala Cys Asp Leu Thr Ile Asp Glu Met Glu Ser Ala 
     2130                2135                2140
Ala Ser Thr Leu Leu Asn Gly Ser Val Cys Pro Arg Ala Asn Gly Asp 
 2145                2150                2155                2160
Met Gly Pro Ile Ser His Arg Gln Asp Tyr Glu Leu Gln Asp Phe Gly 
                 2165                2170                2175
Pro Gly Tyr Ser Asp Glu Glu Pro Asp Pro Gly Arg Glu Glu Glu Asp 
             2180                2185                2190
Leu Ala Asp Glu Met Ile Cys Ile Thr Thr Leu 
         2195                2200



<210> 8124
<211> 7635
<212> DNA
<213> Homo sapiens
<308> M76558
<400> 8124

gggcgagcg  ctccgtccc  ggatgtgag  tccggctgc  cgcggtccc  agccagcgg  60
gcgcgggcg  cggcggcgg  caccgggca  cgcggcggg  gggcagacg  gcgggcatg  120
ggggagcgc  gagcggccc  ggcggccgg  ccggcatca  cgcggcgtc  ctccgctag  180
ggaggggac  agccagttc  cctttgcag  aaaaaatta  atgtatata  tattaagat  240
atatataca  tggatttta  ttttttaaa  agtttattt  gctccattt  tgaaaaaga  300
agagcttgg  tggcgagcg  ttttttttt  aaatcaatt  tccttattt  ctgttattt  360
tccccgtcc  tccccaccc  cctgctgaa  cgagaataa  ggcagggac  gcggctcct  420
cctcttggt  atccccttc  ccattccgc  cccgcccca  cgcccagca  agtgccctg  480
acacagtag  cgctcaata  atgttcgtg  atgatgatg  tgatgatga  gaaaaaaat  540
cagcatcaa  ggcagcagc  agcggacca  gcgaacgag  caaactatg  aagaggcac  600
agacttcct  tttctggtg  aggaccaac  tctcagccg  atagctcca  gcaaactgt  660
ctgtcttgg  aagctgcaa  cgatgctgc  agacaggcc  aggctgccc  aactatgag  720
acctctgca  ccccacctg  aggatctct  tcccaaaga  aacgtcagc  atacgccaa  780
agcaaaaaa  agggtaact  gtccaacag  cgacctgcc  gcgcccttt  ctgtttatc  840
ctcaataac  ccatccgaa  agcctgcat  agtatagtg  aatggaaac  atttgacat  900
tttatatta  tggctattt  tgccaattg  gtggcctta  ctatttaca  cccattccc  960
gaagatgat  ctaattcaa  aaatcataa  ttggaaaaa  tagaatatg  cttcctgat  1020
atttttaca  tcgagacat  tttgaagat  atagcgtat  gattattgc  acatcctaa  1080
gcttatgtt  ggaatggat  gaatttact  gattttgtt  tagtaatag  aggattgtt  1140
agtgtaatt  tggaacaat  aaccaaaga  acagaaggc  ggaaccact  aagcggcaa  1200
tctggaggc  ttgatgtca  agccctccg  gcctttcga  tgttgcgac  acttcgact  1260
gtgtcagga  tgcccagtt  acaagttgt  ctgaactcc  ttataaaag  catggttcc  1320
ctccttcac  tagcccttt  ggtattatt  gtaatcata  tctatgcta  tataggatt  1380
gaacttttt  ttggaaaaa  gcacaaaac  tgttttttt  ctgactcag  tatcgtagc  1440
gaagaggac  cagctccat  tgcgttctc  gggaatgga  gccagtgta  tgccaatgg  1500
acggaatgt  ggagtggct  ggttggccc  aacggaggc  tcaccaact  tgataactt  1560
gcctttgcc  tgcttactg  gtttcagtg  atcaccatg  agggctgga  agacgtgct  1620
tactggatg  atgatgcta  gggatttga  ttgccctgg  tgtattttg  cagtctcgt  1680
atctttggg  catttttcg  actaaatct  gtacttggt  tattgagcg  agaattctc  1740
aaggaaaga  agaaggcaa  agcacgggg  gatttccag  agctccggg  gaagcagca  1800
ctggaggag  atctaaagg  ctacttgga  tggatcacc  aagctgagg  catcgatcc  1860
gagaatgag  aagaaggag  agaggaagg  aaacgaaat  ctagcatgc  caccagcga  1920
actgagtct  tgaacacag  gaacgtcag  ggtgaaggc  agaaccgag  ctgctgtgg  1980
agtctctgt  aagccatct  aaaatccaa  ctcagccga  gctggcgtc  ctggaaccg  2040
ttcaatcgc  gaagatgta  ggccgccgt  aagtctgtc  cgttttact  gctggttat  2100
gtcctggtg  ttctgaaca  cttaaccat  tcctctgag  actacaatc  gccagattg  2160
ttgacacag  ttcaagata  tgccaacaa  gtcctcttg  ctctgttca  ctgcgagat  2220
ctggtaaaa  tgtacagct  gggcctcca  gcatatttc  tctctcttt  caaccggtt  2280
gattgcttc  tggtgtgtg  tggaatcac  gagacgatc  tggtggaac  ggaaatcat  2340
tctcccctg  ggatctctg  gtttcggtg  gtgcgcctc  taagaatct  caaagtgac  2400
aggcactgg  cttccctgt  caacttagt  gcatcctta  taaactcca  gaagtccag  2460
gcttcgctg  tgcttctgc  ttttctctt  attatcatc  tttccttgc  tgggatgca  2520
ctgtttggc  gcaagttta  ttttgatga  acgcaaacc  agcggagca  ctttgacaa  2580
ttccctcaa  cacttctca  agtgttcca  atcctgaca  gcgaagact  gaatgctgt  2640
atgtacgat  gcatcatgg  ttacggggg  ccatcctct  caggaatga  cgtctgcat  2700
tacttcatc  tcctcttca  ttgtggtaa  tatattcta  tgaatgtct  cttggccat  2760
gctgtagac  atttggctg  tgctgaaag  ctgaacact  ctcagaaag  agaagcgga  2820
gaaaaggag  ggaaaaaga  tgccagaaa  gagagccta  aaaataaaa  gaacaacaa  2880
ccagaagtc  accagatag  caacagtga  aacaaggtt  caattgatg  ctatagaga  2940
gaggatgaa  acaaggacc  ctatccgcc  tgcgatgtg  cagtagggg  agaggaaga  3000
gaagaggag  aggatgaac  tgaggttcc  gccggaccc  gtcctcgaa  gatctcgga  3060
ttgaacatg  aggaaaaaa  tgcccccat  cctgaaggg  gcgctttct  cattcttag  3120
aagaccaac  cgatccgcg  aggctgcca  aagctcatc  accaccaca  cttcaccaa  3180
ctcatcctt  tcttcatca  gctgagcag  gctgccctg  ccgcagagg  ccccatccg  3240
agccactcc  tccggaaca  gatactggg  tactttgac  atgccttca  agccatctt  3300
actgttgag  tcctgttga  gatgacaac  tttggagct  tcctccaca  aggggcctt  3360
tgcaggaac  acttcaatt  gctggatat  ctggtggtt  gggtgtctc  ggtgtcatt  3420
gggattcaa  ccagtgcca  ctccgttgt  aagattctg  gggtcttaa  ggtcctgcg  3480
cccctcagg  ccatcaaca  agcaaaagg  cttaagcac  tggtccagt  cgtcttcgt  3540
gccatccgg  ccatcggca  catcatgat  gtcaccacc  tcctgcagt  catgtttgc  3600
tgtatcggg  tccagttgt  caaggggaa  ttctatcgc  gtacggatg  agccaaaag  3660
aaccctgaa  aatgcaggg  acttttcat  ctctacaag  atggggatg  tgacagtcc  3720
gtggtccgt  aacggatct  gcaaaacag  gatttcaac  tcgacaacg  cctctctgc  3780
atgatggcg  tcttcacag  ctccacgtt  gagggctgg  ctgcgttgc  gtataaagc  3840
atcgactcg  atggagaga  catcggccc  atctacaac  accgcgtgg  gatctccat  3900
ttcttcatc  tctacatca  cattgtagc  ttcttcatg  tgaacatct  tgtgggctt  3960
gtcatcgtt  catttcagg  acaaggaga  aaagagtat  agaactgtg  gctggacaa  4020
aatcagcgt  agtgtgttg  atacgcctt  aaagcacgt  ccttgcgga  atacatccc  4080
aaaaacccc  accagtaca  gttctggta  gtggtgaac  cttcgcctt  cgaatacat  4140
atgtttgtc  tcatcatgc  caacacact  tgcttggcc  tgcagcact  cgagcagtc  4200
aagatgttc  atgatgcca  ggacattct  aacatggtc  tcaccgggg  gttcaccgt  4260
gagatggtt  tgaaagtca  cgcatttaa  cctaagggg  attttagtg  cgcctggaa  4320
acgtttgac  ccctcatcg  aatcggcag  attatagac  tggccctca  cgaagcaga  4380
ccaactgaa  gtgaaaatg  ccctgtccc  actgctaca  ctgggaact  tgaagagag  4440
aatagaatc  ccatcacct  tttccgtct  ttccgagtg  tgcgattgg  gaagcttct  4500
agcaggggg  aaggcatcc  gacattgct  tggactttt  ttaagttct  tcaggcgct  4560
ccgtatgtg  ccctcctca  agccatgct  ttcttcatc  atgcggtca  tggcatgca  4620
atgtttggg  aagttgcca  gagagataa  aaccagatc  ataggaaca  taacttcca  4680
acgtttccc  aggcggtgc  gctgctctt  aggtgtgca  caggtgagg  ctggcagga  4740
atcatgctg  cctgtctcc  agggaagct  tgtgaccct  agtcagatt  caaccccgg  4800
gaggagcat  catgtggga  caactttgc  attgtctat  tcatcagtt  ttacatgct  4860
tgtgcattt  tgatcatca  tctgtttgt  gctgtcatc  tggataatt  cgactatct  4920
acccgggac  ggtctattt  ggggcctca  catttagat  aattcaaaa  aatatggtc  4980
gaatatgac  ctgaggcaa  gggaaggat  aaacacctt  atgtggtca  tctgcttcg  5040
cgcatccag  ctcccctgg  gtttgggaa  ttatgtcca  acagggtag  gtgcaagag  5100
ttagttgcc  tgaacatgc  tctcaacag  gacgggaca  tcatgttta  tgcaaccct  5160
tttgctttg  ttcgaacgg  tcttaagat  aagaccgaa  ggaacctgg  gcaagctaa  5220
gaagaactt  gggctgtga  aaagaaaat  tggaagaaa  ccagcatga  attacttga  5280
caagttgtc  ctccagctg  tgatgatga  gtaaccgtg  ggaagttct  tgccacttt  5340
ctgatacag  actacttta  gaaattcaa  aaacggaaa  aacaaggac  ggtgggaaa  5400
taccctgcg  agaacacca  aattgccct  caggcggga  taaggacac  gcatgacat  5460
gggccagaa  tccggcgtg  tatatcgtg  gatttgcaa  atgacgagc  tgaggaaac  5520
aaacgagaa  aagaagatg  tgtgttcaa  agaaatggt  ccctgcttg  aaaccatgt  5580
aatcatgtt  atagtgata  gagagattc  cttcagcag  ccaatacca  ccaccgtcc  5640
ctgcatgtc  aaaggcctt  aattccacc  gcaagtgat  ctgagaaac  gctgtttcc  5700
ccagcagga  attcggtgt  tcataacca  cataaccat  attccatag  aaagcaagt  5760
cccacctca  caaatgcca  tctcaataa  gccaatatg  ccaaagctg  ccatggaaa  5820
cggcccagc  ttgggaacc  tgagcatgt  tctgaaaat  ggcatcatt  ttcccacaa  5880
catgaccgg  agcctcaga  aaggtccag  gtgaaaaga  cccgctatt  tgaaactta  5940
attaggtcc  actcaggag  tgaacagct  ccaactatt  gccgggaag  cccagagat  6000
catggctat  tcagggacc  ccactgctt  ggggagcag  agtatttca  tagtgagga  6060
tgctacgag  atgacagct  gcccacctg  agcaggcaa  actatggct  ctacagcag  6120
tacccaggc  gaaacatcg  ctctgagag  ccccgaggc  accatcatc  ccaaggatt  6180
ttggaggac  atgactcgc  cgtttgcta  gattcacgg  gatctccaa  gagacgcct  6240
ctacctccc  ccccagcat  ccaccggag  tcctccttc  actttgagt  cctgcgccg  6300
cagagcagc  aggaagagg  cccgtcgtc  cccatcttc  cccatcgca  ggccctgcc  6360
ctgcatcta  tgcagcaac  gatcatggc  gttgccggc  tagattcaa  taaagccca  6420
aagtactca  cgagtcact  gacccggtc  tgggccacc  ctccagcaa  ccctcccta  6480
cgggactgg  caccgtgct  cacccccct  atccaagtg  agcagtcag  ggccctgga  6540
caggtgaac  gcagcctgc  gtccctgca  cgcagctcc  ggtacacag  cgagcccga  6600
atctcctac  ggactttca  accagccag  ctgactgtc  ccagcagct  ccggaacaa  6660
aacagcgac  agcagagga  tgcggacag  ttggtggag  cagtcctga  atccgaagg  6720
ttgggacgc  atgcaaggg  cccaaaatt  gtgtcagca  caaaacacg  aatcgctga  6780
gcctgtgac  tcaccatcg  cgagatgga  agtgcagcc  gcaccctgc  taatgggaa  6840
gtgcgtccc  gagccaacg  ggatgtggg  cccctctca  accggcagg  ctatgagct  6900
caggacttt  gtcctggct  cagcgacga  gagccagac  ctgggaggg  tgaggagga  6960
ctggcggat  aaatgatat  catcaccac  ttgtagccc  cagcgaggg  cagactggc  7020
ctggcctca  gtggggcgc  ggagagcca  gggaaaagt  cctcatagt  aggaaagtt  7080
aggcactag  tgggagtaa  attcaatta  ttagacttt  gtataagag  tgtcatgcc  7140
caagaaagc  ataaacctg  taggaacag  tcccaagcg  ttgagcctg  cagagtacc  7200
tgcgctcgg  cccagctgc  ggaaacagc  ggccccgcc  tctcacaga  gatgggtga  7260
gaggccaga  ctgccctgc  ccattgtcc  gatgggcac  gctgtggag  ctgcttctc  7320
catgtacca  ggcaccagg  ccacccaac  gaaggcatg  cggcggggt  caggggaaa  7380
ttaaaggtg  tgacgatca  cacacctgt  tcgttacct  agccatcgg  ctagcatat  7440
agtcactgg  cccaacata  ccattttta  accctttcc  ccaaataca  tgcgtcctg  7500
ttcctgttt  gctgttctg  aatacggtg  gtaagtaag  cagaaccca  ctaccagtg  7560
ttattgcga  ggcaatggg  cctcataaa  aaggttttc  gtgatgtga  gccagttta  7620
ataagagaa  atcac  7635



<210> 8125
<211> 2161
<212> PRT
<213> Homo sapiens
<308> Q01668
<400> 8125

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
  1               5                  10                  15
Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
             20                  25                  30
Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
         35                  40                  45
Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
     50                  55                  60
Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
 65                  70                  75                  80
Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                 85                  90                  95
Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
             100                105                110
Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
         115                120                125
Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
     130                135                140
Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
 145                150                155                160
Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                 165                170                175
Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
             180                185                190
Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
         195                200                205
Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
     210                215                220
Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
 225                230                235                240
Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                 245                250                255
Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
             260                265                270
His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
         275                280                285
Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
     290                295                300
Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
 305                310                315                320
Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                 325                330                335
Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
             340                345                350
Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
         355                360                365
Val Leu Tyr Trp Met Asn Asp Ala Met Gly Phe Glu Leu Pro Trp Val 
     370                375                380
Tyr Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu 
 385                390                395                400
Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                 405                410                415
Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
             420                425                430
Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
         435                440                445
Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
     450                455                460
Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
 465                470                475                480
Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile 
                 485                490                495
Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn 
             500                505                510
Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr Phe Tyr Trp Leu 
         515                520                525
Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile Ser Ser Glu His 
     530                535                540
Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp Ile Ala Asn Lys 
 545                550                555                560
Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val Lys Met Tyr Ser 
                 565                570                575
Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys 
             580                585                590
Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu Val Glu Leu Glu 
         595                600                605
Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu 
     610                615                620
Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu Cys Asn Leu Val 
 625                630                635                640
Ala Ser Leu Leu Asn Ser Met Lys Ser Ser Ala Ser Leu Leu Leu Leu 
                 645                650                655
Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe 
             660                665                670
Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys Arg Ser Thr Phe 
         675                680                685
Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly 
     690                695                700
Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly 
 705                710                715                720
Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe 
                 725                730                735
Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
             740                745                750
Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala Gln Lys Glu Glu 
         755                760                765
Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu 
     770                775                780
Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp 
 785                790                795                800
Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp 
                 805                810                815
Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu 
             820                825                830
Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile 
         835                840                845
Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser 
     850                855                860
Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg Val Gly Cys His 
 865                870                875                880
Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile Leu Val Phe Ile 
                 885                890                895
Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His 
             900                905                910
Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr Ala 
         915                920                925
Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr Phe Gly Ala Phe 
     930                935                940
Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met 
 945                950                955                960
Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala 
                 965                970                975
Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
             980                985                990
Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys Val 
         995                1000                1005
Phe Val Ala Ile Arg Thr Ile Gly Asn Ile Met Ile Val Thr Thr Leu 
     1010                1015                1020
Leu Gln Phe Met Phe Ala Cys Ile Gly Val Gln Leu Phe Lys Gly Lys 
 1025                1030                1035                1040
Phe Tyr Arg Cys Thr Asp Glu Ala Lys Ser Asn Pro Glu Glu Cys Arg 
                 1045                1050                1055
Gly Leu Phe Ile Leu Tyr Lys Asp Gly Asp Val Asp Ser Pro Val Val 
             1060                1065                1070
Arg Glu Arg Ile Trp Gln Asn Ser Asp Phe Asn Phe Asp Asn Val Leu 
         1075                1080                1085
Ser Ala Met Met Ala Leu Phe Thr Val Ser Thr Phe Glu Gly Trp Pro 
     1090                1095                1100
Ala Leu Leu Tyr Lys Ala Ile Asp Ser Asn Gly Glu Asn Ile Gly Pro 
 1105                1110                1115                1120
Ile Tyr Asn His Arg Val Glu Ile Ser Ile Phe Phe Ile Ile Tyr Ile 
                 1125                1130                1135
Ile Ile Val Ala Phe Phe Met Met Asn Ile Phe Val Gly Phe Val Ile 
             1140                1145                1150
Val Thr Phe Gln Glu Gln Gly Glu Lys Glu Tyr Lys Asn Cys Glu Leu 
         1155                1160                1165
Asp Lys Asn Gln Arg Gln Cys Val Glu Tyr Ala Leu Lys Ala Arg Pro 
     1170                1175                1180
Leu Arg Arg Tyr Ile Pro Lys Asn Pro Tyr Gln Tyr Lys Phe Trp Tyr 
 1185                1190                1195                1200
Val Val Asn Ser Ser Pro Phe Glu Tyr Met Met Phe Val Leu Ile Met 
                 1205                1210                1215
Leu Asn Thr Leu Cys Leu Ala Met Gln His Tyr Glu Gln Ser Lys Met 
             1220                1225                1230
Phe Asn Asp Ala Met Asp Ile Leu Asn Met Val Phe Thr Gly Val Phe 
         1235                1240                1245
Thr Val Glu Met Val Leu Lys Val Ile Ala Phe Lys Pro Lys Gly Tyr 
     1250                1255                1260
Phe Ser Asp Ala Trp Asn Thr Phe Asp Ser Leu Ile Val Ile Gly Ser 
 1265                1270                1275                1280
Ile Ile Asp Val Ala Leu Ser Glu Ala Asp Pro Thr Glu Ser Glu Asn 
                 1285                1290                1295
Val Pro Val Pro Thr Ala Thr Pro Gly Asn Ser Glu Glu Ser Asn Arg 
             1300                1305                1310
Ile Ser Ile Thr Phe Phe Arg Leu Phe Arg Val Met Arg Leu Val Lys 
         1315                1320                1325
Leu Leu Ser Arg Gly Glu Gly Ile Arg Thr Leu Leu Trp Thr Phe Ile 
     1330                1335                1340
Lys Phe Phe Gln Ala Leu Pro Tyr Val Ala Leu Leu Ile Ala Met Leu 
 1345                1350                1355                1360
Phe Phe Ile Tyr Ala Val Ile Gly Met Gln Met Phe Gly Lys Val Ala 
                 1365                1370                1375
Met Arg Asp Asn Asn Gln Ile Asn Arg Asn Asn Asn Phe Gln Thr Phe 
             1380                1385                1390
Pro Gln Ala Val Leu Leu Leu Phe Arg Cys Ala Thr Gly Glu Ala Trp 
         1395                1400                1405
Gln Glu Ile Met Leu Ala Cys Leu Pro Gly Lys Leu Cys Asp Pro Glu 
     1410                1415                1420
Ser Asp Tyr Asn Pro Gly Glu Glu His Thr Cys Gly Ser Asn Phe Ala 
 1425                1430                1435                1440
Ile Val Tyr Phe Ile Ser Phe Tyr Met Leu Cys Ala Phe Leu Ile Ile 
                 1445                1450                1455
Asn Leu Phe Val Ala Val Ile Met Asp Asn Phe Asp Tyr Leu Thr Arg 
             1460                1465                1470
Asp Trp Ser Ile Leu Gly Pro His His Leu Asp Glu Phe Lys Arg Ile 
         1475                1480                1485
Trp Ser Glu Tyr Asp Pro Glu Ala Lys Gly Arg Ile Lys His Leu Asp 
     1490                1495                1500
Val Val Thr Leu Leu Arg Arg Ile Gln Pro Pro Leu Gly Phe Gly Lys 
 1505                1510                1515                1520
Leu Cys Pro His Arg Val Ala Cys Lys Arg Leu Val Ala Met Asn Met 
                 1525                1530                1535
Pro Leu Asn Ser Asp Gly Thr Val Met Phe Asn Ala Thr Leu Phe Ala 
             1540                1545                1550
Leu Val Arg Thr Ala Leu Lys Ile Lys Thr Glu Gly Asn Leu Glu Gln 
         1555                1560                1565
Ala Asn Glu Glu Leu Arg Ala Val Ile Lys Lys Ile Trp Lys Lys Thr 
     1570                1575                1580
Ser Met Lys Leu Leu Asp Gln Val Val Pro Pro Ala Gly Asp Asp Glu 
 1585                1590                1595                1600
Val Thr Val Gly Lys Phe Tyr Ala Thr Phe Leu Ile Gln Asp Tyr Phe 
                 1605                1610                1615
Arg Lys Phe Lys Lys Arg Lys Glu Gln Gly Leu Val Gly Lys Tyr Pro 
             1620                1625                1630
Ala Lys Asn Thr Thr Ile Ala Leu Gln Ala Gly Leu Arg Thr Leu His 
         1635                1640                1645
Asp Ile Gly Pro Glu Ile Arg Arg Ala Ile Ser Cys Asp Leu Gln Asp 
     1650                1655                1660
Asp Glu Pro Glu Glu Thr Lys Arg Glu Glu Glu Asp Asp Val Phe Lys 
 1665                1670                1675                1680
Arg Asn Gly Ala Leu Leu Gly Asn His Val Asn His Val Asn Ser Asp 
                 1685                1690                1695
Arg Arg Asp Ser Leu Gln Gln Thr Asn Thr Thr His Arg Pro Leu His 
             1700                1705                1710
Val Gln Arg Pro Ser Ile Pro Pro Ala Ser Asp Thr Glu Lys Pro Leu 
         1715                1720                1725
Phe Pro Pro Ala Gly Asn Ser Val Cys His Asn His His Asn His Asn 
     1730                1735                1740
Ser Ile Gly Lys Gln Val Pro Thr Ser Thr Asn Ala Asn Leu Asn Asn 
 1745                1750                1755                1760
Ala Asn Met Ser Lys Ala Ala His Gly Lys Arg Pro Ser Ile Gly Asn 
                 1765                1770                1775
Leu Glu His Val Ser Glu Asn Gly His His Ser Ser His Lys His Asp 
             1780                1785                1790
Arg Glu Pro Gln Arg Arg Ser Ser Val Lys Arg Thr Arg Tyr Tyr Glu 
         1795                1800                1805
Thr Tyr Ile Arg Ser Asp Ser Gly Asp Glu Gln Leu Pro Thr Ile Cys 
     1810                1815                1820
Arg Glu Asp Pro Glu Ile His Gly Tyr Phe Arg Asp Pro His Cys Leu 
 1825                1830                1835                1840
Gly Glu Gln Glu Tyr Phe Ser Ser Glu Glu Cys Tyr Glu Asp Asp Ser 
                 1845                1850                1855
Ser Pro Thr Trp Ser Arg Gln Asn Tyr Gly Tyr Tyr Ser Arg Tyr Pro 
             1860                1865                1870
Gly Arg Asn Ile Asp Ser Glu Arg Pro Arg Gly Tyr His His Pro Gln 
         1875                1880                1885
Gly Phe Leu Glu Asp Asp Asp Ser Pro Val Cys Tyr Asp Ser Arg Arg 
     1890                1895                1900
Ser Pro Arg Arg Arg Leu Leu Pro Pro Thr Pro Ala Ser His Arg Arg 
 1905                1910                1915                1920
Ser Ser Phe Asn Phe Glu Cys Leu Arg Arg Gln Ser Ser Gln Glu Glu 
                 1925                1930                1935
Val Pro Ser Ser Pro Ile Phe Pro His Arg Thr Ala Leu Pro Leu His 
             1940                1945                1950
Leu Met Gln Gln Gln Ile Met Ala Val Ala Gly Leu Asp Ser Ser Lys 
         1955                1960                1965
Ala Gln Lys Tyr Ser Pro Ser His Ser Thr Arg Ser Trp Ala Thr Pro 
     1970                1975                1980
Pro Ala Thr Pro Pro Tyr Arg Asp Trp Thr Pro Cys Tyr Thr Pro Leu 
 1985                1990                1995                2000
Ile Gln Val Glu Gln Ser Glu Ala Leu Asp Gln Val Asn Gly Ser Leu 
                 2005                2010                2015
Pro Ser Leu His Arg Ser Ser Trp Tyr Thr Asp Glu Pro Asp Ile Ser 
             2020                2025                2030
Tyr Arg Thr Phe Thr Pro Ala Ser Leu Thr Val Pro Ser Ser Phe Arg 
         2035                2040                2045
Asn Lys Asn Ser Asp Lys Gln Arg Ser Ala Asp Ser Leu Val Glu Ala 
     2050                2055                2060
Val Leu Ile Ser Glu Gly Leu Gly Arg Tyr Ala Arg Asp Pro Lys Phe 
 2065                2070                2075                2080
Val Ser Ala Thr Lys His Glu Ile Ala Asp Ala Cys Asp Leu Thr Ile 
                 2085                2090                2095
Asp Glu Met Glu Ser Ala Ala Ser Thr Leu Leu Asn Gly Asn Val Arg 
             2100                2105                2110
Pro Arg Ala Asn Gly Asp Val Gly Pro Leu Ser His Arg Gln Asp Tyr 
         2115                2120                2125
Glu Leu Gln Asp Phe Gly Pro Gly Tyr Ser Asp Glu Glu Pro Asp Pro 
     2130                2135                2140
Gly Arg Asp Glu Glu Asp Leu Ala Asp Glu Met Ile Cys Ile Thr Thr 
 2145                2150                2155                2160
Leu 
                 2165



<210> 8126
<211> 4056
<212> DNA
<213> Rattus norvegicus
<308> U14005
<400> 8126

ggatccccc  tgcaacaat  agagatgct  agtgtgtcg  ctttgagca  ggagtacct  60
cccagaaac  tttattttc  taattcacg  tgagccttt  gctttaaag  cgctgttct  120
aaacgttct  aaactcagt  ggaacaagc  gatccgaac  aaggcaaat  aatcgaatc  180
tgcaaagta  caaagcaga  gccttttcc  aacagccag  acaaagcta  atgaaaaat  240
tcagtcatc  actagatac  gtatttccc  cactagaca  gagctgggg  ctgtagatc  300
cccctcccc  aaacaggag  ccgagaagg  acaaaacaa  gtattcatt  ctaaacgag  360
catcacttc  agctgcacc  tctacctct  cgcactcgc  gtttgaaag  cctcggctg  420
tacttctct  tacctgcct  caaacacac  tggaggtgg  ggcgagagg  agggagccc  480
ccgccacgt  tgcataagg  gagggagga  gggattggg  ctgagggca  ttccctgag  540
acagttagt  ctgcctaaa  tgcaaggct  ccccattcc  ctgtacccc  aaactggag  600
aaacagtgt  ggggcctgg  gacgcctgt  cacggtcca  gcagagccc  ggaaccctg  660
gctttgatg  tgcagcagc  atcgcctgt  ggcacctgg  tttctgggg  gcggggcct  720
ccccaggtg  gcggagagc  aaggccacc  gagccagcc  agaggaccc  aggagcctc  780
tccggggga  acggtacaa  agagcggct  gtcggtgcc  ccagcagca  gcaccgggc  840
ccacgggcc  ggctccggg  aggggcgcc  gcgcggcgg  accgagggg  ttaaccggg  900
ggcccgcgg  cgnagcgcg  ttaaccctc  gtcagccgc  ccagcccgg  ggtggcggc  960
tccgagtcg  gcgccgtgg  gcccggggg  cgcgtgggc  gcaggccgg  agctggggc  1020
cggcgcggc  ggtgggagg  ccgggcgcg  gggggaggg  gggggacgg  ggcggcggg  1080
gcgcagcgt  gccaggacg  anccggcgt  cagcgcggc  cggcgggcg  ggagcgggc  1140
ggcgggcgg  cgagcgcct  cgtccccgg  tgtgagctc  ggctgcccg  ggtcccgag  1200
cagcggcgg  gcgggcggc  acggcggcg  cggggcacc  ggcaccggg  cgggcgggc  1260
gacgggcgg  atggggggc  cgtcgagcg  ccccggcgg  cgggcgggc  ccaccgcgg  1320
gtccctccg  tagaggagg  gaccaagcc  attctcctt  gcagcaaaa  aagagaaaa  1380
agaaaaaaa  gaaaaattt  cttgtatat  ttactaaga  aatatatac  tctgatttt  1440
ttttttaca  aaagtttat  ttgctccat  tttcaaaaa  agaaggagc  tgggtggca  1500
gcggttttt  taaattatt  ttattttga  tatttgtct  tgtccttcc  caccccctg  1560
tgaagcgaa  atagggcag  gaccgcggc  cctacctat  agtaacctc  catacccgt  1620
cctccccct  cctaacgct  agcatagtg  cctgcacac  gtaggcgct  aataaatgt  1680
cgtggatga  gatgatgat  atgatgaaa  aaatgcagc  tcaacggca  cagcaagag  1740
accacgcga  cggtgagca  ccagagccc  ggtacccgc  gccaaacct  atcctatca  1800
gatcctact  ttcccactc  ccaaccccc  tctccgatg  gttgggtgg  ttgaggggg  1860
tggagatga  gcttttggc  tggtgtcat  tacatagaa  ggggtgatg  gcggcagct  1920
cttcgttct  ctcttcagg  cctgaatgt  agagttaat  ctgcatttg  tggggtggg  1980
cggccattg  gtgtgtgga  tactgtgca  ccaaggggc  agagtgagg  gattcgggt  2040
caagtgccc  cgggctcaa  ttttctctt  cattgcccc  gagcgatgg  agaggtgtt  2100
gtcttcagc  tgaacccct  ttccagcct  cccccccac  cccacgcct  tggttgact  2160
agaggaagg  ctttagtag  atcaggaaa  ttctaggat  gctccgctt  tactcgttg  2220
gtcacttgg  aaagtgcac  tccatcatc  catgggaga  gccccccgg  cttgggatc  2280
gggggaaca  ggtcaggtg  agcgagtat  cccgctcgc  ccctgtgcc  cctgtgcac  2340
cgtcgtcgg  aacctagca  tgcccagag  gttgctgcc  ctgtggggc  ctgcaactc  2400
gccctggcc  tggcaccac  tgcagtttc  acaccagcg  ggctgggtc  gagaaggtt  2460
ggttgcttt  ggctaggtt  cctccgtgg  ggtcgttgg  atctcccaa  cctgttttc  2520
tgaagcctt  tccggtgag  acttctcaa  gggaaagct  ggcaaaatt  gttcctgat  2580
tcagattga  tgccacctg  ctgctttgc  gctgtccca  gctcatagg  cagtggggc  2640
ggagacctg  gcttgcttt  actctttgc  tagtgataa  tagctttgc  aacgcctgg  2700
tctccaacc  ctctccacc  ttctcactt  gacatctgc  tcagcagag  tgatgatgg  2760
ggcccaacg  gggcacctg  gagaccgtc  gagggatgg  cagacccat  gtgaggcgg  2820
ctccgcaca  gaagagacc  gaccccccc  ccccccccc  cgccccacc  ttgagtatt  2880
tgccttgtg  gtacctgga  gctactcta  gccgagata  ttcttgaat  ggccttgag  2940
ttccctggc  taacgcacc  tgtctctta  gtgtagggg  gcaggctgg  ttggctgct  3000
ctgctgcaa  taaaaaaaa  aaaaaagcc  taaagatgt  tttctgttt  cggaagctt  3060
tggaggaaa  gagtcccaa  caccatgaa  tttcatttg  aggaagtgt  agtgcataa  3120
ctagatatt  gttatgggg  ttttgctat  gcctggtgc  agtgaggag  ttgtttttt  3180
tttcttcta  gtagaaaaa  tgcatttat  gctgtggag  gctgttgga  ggacaccct  3240
aaaatggtt  agactgttg  atttattgg  tctgtgtgt  tgtgtgtgt  tgtgtgtgt  3300
tgtgtgttg  taataaatt  tagagaaag  cagctgtat  gatgtatct  ttaagccat  3360
agagatacg  gtgttttca  agtcaggaa  agacacagg  taaattcga  aatagcccc  3420
gtttgtcag  agagaggca  tcatggctt  cctttgaag  cacaggtat  ggagagtac  3480
agtgtggct  ggtgtggtg  agcaacgca  gtctagtgc  cagggcaga  ctctgctga  3540
ttctgcatt  cctggccaa  ccccactac  tgtgacaca  ggttcaaaa  gggaaacac  3600
agatgggag  cacttttgc  tttttaaaa  gatagtata  atcaaggtc  ttctttttt  3660
tttttttct  ccccaaaga  aaataatct  ttttctcct  ctcctcaga  gcaaactat  3720
caagaggca  cagactccc  atttctggt  aaggaccaa  ttctcagcc  aacagctcc  3780
agcaaaccg  cctgtcttg  caagctgca  ttgatgctg  tagacaggc  aaggccgcc  3840
agaccatga  cacgtctgc  cccccacct  taggatctc  ctcccaaag  aaacgtcag  3900
aatacgcca  gagcaaaaa  cagggtaac  cgtctaaca  ccgacctgc  cgtgccctc  3960
tctgtttat  cctcaataa  cccatccga  gagcctgca  tagtatagt  gattggaag  4020
atccttttt  tgtgggaaa  tctttcaaa  ggatcc  4056



<210> 8127
<211> 2203
<212> PRT
<213> Rattus norvegicus
<308> AAB60515
<400> 8127

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
  1               5                  10                  15
Gln Glu Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
             20                  25                  30
Pro Ile Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
         35                  40                  45
Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
     50                  55                  60
Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
 65                  70                  75                  80
Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                 85                  90                  95
Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
             100                105                110
Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Asp Trp Lys Pro Phe 
         115                120                125
Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
     130                135                140
Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
 145                150                155                160
Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                 165                170                175
Phe Leu Lys Ile Ile Ala Ser Gly Leu Leu Leu His Pro Asn Ala Ser 
             180                185                190
Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
         195                200                205
Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
     210                215                220
Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
 225                230                235                240
Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                 245                250                255
Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
             260                265                270
His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
         275                280                285
Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
     290                295                300
Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
 305                310                315                320
Gly Asn Gly Arg Gln Cys Ala Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                 325                330                335
Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
             340                345                350
Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
         355                360                365
Val Leu Tyr Trp Val Asn Asp Ala Ile Gly Trp Glu Trp Pro Trp Val 
     370                375                380
Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser Phe Phe Val Leu Asn Leu 
 385                390                395                400
Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                 405                410                415
Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
             420                425                430
Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
         435                440                445
Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
     450                455                460
Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
 465                470                475                480
Gly Glu Gly Glu Thr Gln Gly Cys Cys Gly Ser Leu Trp Cys Trp Trp 
                 485                490                495
Lys Arg Arg Gly Ala Ala Lys Thr Gly Pro Ser Gly Cys Arg Arg Trp 
             500                505                510
Gly Gln Ala Ile Ser Lys Ser Lys Leu Arg Ser His Gly Ala Arg Glu 
         515                520                525
Ala Leu Cys Val Cys Arg Cys Ser Leu Glu Ser Leu Val Lys Leu Trp 
     530                535                540
Thr Ser Arg Phe Ser Ala His Leu Gln Ala Ala Tyr Val Arg Pro Tyr 
 545                550                555                560
Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn Arg Arg Arg Cys Arg 
                 565                570                575
Ala Ala Val Lys Ser Val Thr Phe Tyr Trp Leu Val Ile Val Leu Val 
             580                585                590
Phe Leu Asn Thr Leu Thr Ile Ser Ser Glu His Tyr Asn Gln Pro Asp 
         595                600                605
Trp Leu Thr Gln Ile Gln Asp Ile Ala Asn Lys Val Leu Leu Ala Leu 
     610                615                620
Phe Thr Cys Glu Met Leu Val Lys Met Tyr Ser Leu Gly Leu Gln Ala 
 625                630                635                640
Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly 
                 645                650                655
Gly Ile Thr Glu Thr Ile Leu Val Glu Leu Glu Leu Met Ser Pro Leu 
             660                665                670
Gly Val Ser Val Phe Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val 
         675                680                685
Thr Arg His Trp Thr Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn 
     690                695                700
Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile 
 705                710                715                720
Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn 
                 725                730                735
Phe Asp Glu Thr Gln Thr Lys Arg Ser Thr Phe Asp Asn Phe Pro Gln 
             740                745                750
Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Ala 
         755                760                765
Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly Pro Ser Ser Ser Gly 
     770                775                780
Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr 
 785                790                795                800
Ile Leu Leu Lys Leu Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asp 
                 805                810                815
Ala Glu Ser Leu Asn Thr Ala Gln Lys Glu Glu Ala Glu Glu Lys Glu 
             820                825                830
Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu Asn Lys Lys Asn Asn 
         835                840                845
Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp Asn Lys Val Thr Ile 
     850                855                860
Asp Asp Tyr Gln Glu Glu Ala Glu Asp Lys Asp Pro Tyr Pro Pro Cys 
 865                870                875                880
Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Pro 
                 885                890                895
Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile Ser Glu Leu Asn Met 
             900                905                910
Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser Ala Phe Phe Ile Leu 
         915                920                925
Ser Lys Thr Asn Pro Ile Arg Val Gly Cys His Lys Leu Ile Asn His 
     930                935                940
His Ile Phe Thr Asn Leu Ile Leu Val Phe Ile Met Leu Ser Ser Ala 
 945                950                955                960
Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His Ser Phe Arg Asn Thr 
                 965                970                975
Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr Ala Ile Phe Thr Val Glu 
             980                985                990
Ile Leu Leu Lys Met Thr Thr Phe Gly Ala Phe Leu His Lys Gly Ala 
         995                1000                1005
Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met Leu Val Val Gly Val 
     1010                1015                1020
Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala Ile Ser Val Val Lys 
 1025                1030                1035                1040
Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg 
                 1045                1050                1055
Ala Lys Gly Leu Lys His Val Val Gln Cys Val Phe Val Ala Ile Arg 
             1060                1065                1070
Thr Ile Gly Asn Ile Met Ile Val Thr Thr Leu Leu Gln Phe Met Phe 
         1075                1080                1085
Ala Cys Ile Gly Val Gln Leu Phe Lys Gly Lys Phe Tyr Arg Cys Thr 
     1090                1095                1100
Asp Glu Ala Lys Ser Asn Pro Glu Glu Cys Arg Gly Leu Phe Ile Leu 
 1105                1110                1115                1120
Tyr Lys Asp Gly Asp Val Asp Ser Pro Val Val Arg Glu Arg Ile Trp 
                 1125                1130                1135
Gln Asn Ser Asp Phe Asn Phe Asp Asn Val Leu Ser Ala Met Met Ala 
             1140                1145                1150
Leu Phe Thr Val Ser Thr Phe Glu Gly Trp Pro Ala Leu Leu Tyr Lys 
         1155                1160                1165
Ala Ile Asp Ser Asn Gly Glu Asn Val Gly Pro Val Tyr Asn Tyr Arg 
     1170                1175                1180
Val Glu Ile Ser Ile Phe Phe Ile Ile Tyr Ile Ile Ile Val Ala Phe 
 1185                1190                1195                1200
Phe Met Met Asn Ile Phe Val Gly Phe Val Ile Val Thr Phe Gln Glu 
                 1205                1210                1215
Gln Gly Glu Lys Glu Tyr Lys Asn Cys Glu Leu Asp Lys Asn Gln Arg 
             1220                1225                1230
Gln Cys Val Glu Tyr Ala Leu Lys Ala Arg Pro Leu Arg Arg Tyr Ile 
         1235                1240                1245
Pro Lys Asn Pro Tyr Gln Tyr Lys Phe Trp Tyr Val Val Asn Ser Ser 
     1250                1255                1260
Pro Phe Glu Tyr Met Met Phe Val Leu Ile Met Leu Asn Thr Leu Cys 
 1265                1270                1275                1280
Leu Ala Met Gln His Tyr Glu Gln Ser Lys Met Phe Asn Asp Ala Met 
                 1285                1290                1295
Asp Ile Leu Asn Met Val Phe Thr Gly Val Phe Thr Val Glu Met Val 
             1300                1305                1310
Leu Lys Val Ile Ala Phe Lys Pro Lys Gly Tyr Phe Ser Asp Ala Trp 
         1315                1320                1325
Asn Thr Phe Asp Ser Leu Ile Val Ile Gly Ser Ile Ile Asp Val Ala 
     1330                1335                1340
Leu Ser Glu Ala Asp Asn Ser Glu Glu Ser Asn Arg Ile Ser Ile Thr 
 1345                1350                1355                1360
Phe Phe Arg Leu Phe Arg Val Met Arg Leu Val Lys Leu Leu Ser Arg 
                 1365                1370                1375
Gly Glu Gly Ile Arg Thr Leu Leu Trp Thr Phe Ile Lys Ser Phe Gln 
             1380                1385                1390
Ala Leu Pro Tyr Val Ala Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr 
         1395                1400                1405
Ala Val Ile Gly Met Gln Met Phe Gly Lys Val Ala Met Arg Asp Asn 
     1410                1415                1420
Asn Gln Ile Asn Arg Asn Asn Asn Phe Gln Thr Phe Pro Gln Ala Val 
 1425                1430                1435                1440
Leu Leu Leu Phe Arg Cys Ala Thr Gly Glu Ala Trp Gln Glu Ile Met 
                 1445                1450                1455
Leu Ala Cys Leu Pro Gly Lys Leu Cys Asp Pro Asp Ser Asp Tyr Asn 
             1460                1465                1470
Pro Gly Glu Glu Tyr Thr Cys Gly Ser Asn Phe Ala Ile Val Tyr Phe 
         1475                1480                1485
Ile Ser Phe Tyr Met Leu Cys Ala Phe Leu Ile Ile Asn Leu Phe Val 
     1490                1495                1500
Ala Val Ile Met Asp Asn Phe Asp Tyr Leu Thr Arg Asp Trp Ser Ile 
 1505                1510                1515                1520
Leu Gly Pro His His Leu Asp Glu Phe Lys Arg Ile Trp Ser Glu Tyr 
                 1525                1530                1535
Asp Pro Glu Ala Lys Gly Arg Ile Lys His Leu Asp Val Val Thr Leu 
             1540                1545                1550
Leu Arg Arg Ile Gln Pro Pro Leu Gly Phe Gly Lys Leu Cys Pro His 
         1555                1560                1565
Arg Val Ala Cys Lys Arg Leu Val Ala Met Asn Met Pro Leu Asn Ser 
     1570                1575                1580
Asp Gly Thr Val Met Phe Asn Ala Thr Leu Phe Ala Leu Val Arg Thr 
 1585                1590                1595                1600
Ala Leu Lys Ile Lys Thr Glu Gly Asn Leu Glu Gln Ala Asn Glu Glu 
                 1605                1610                1615
Leu Arg Ala Val Ile Lys Lys Ile Trp Lys Lys Thr Ser Met Lys Leu 
             1620                1625                1630
Leu Asp Gln Val Val Pro Pro Ala Gly Asp Asp Glu Val Thr Val Gly 
         1635                1640                1645
Lys Phe Tyr Ala Thr Phe Leu Ile Gln Asp Tyr Phe Arg Lys Phe Lys 
     1650                1655                1660
Lys Arg Lys Glu Gln Gly Leu Val Gly Lys Tyr Pro Ala Lys Asn Thr 
 1665                1670                1675                1680
Thr Ile Ala Leu Gln Ala Gly Leu Arg Thr Leu His Asp Ile Gly Pro 
                 1685                1690                1695
Glu Ile Arg Arg Ala Ile Ser Cys Asp Leu Gln Asp Asp Glu Pro Glu 
             1700                1705                1710
Asp Ser Lys Pro Glu Glu Glu Asp Val Phe Lys Arg Asn Gly Ala Leu 
         1715                1720                1725
Leu Gly Asn Tyr Val Asn His Val Asn Ser Asp Arg Arg Glu Ser Leu 
     1730                1735                1740
Gln Gln Thr Asn Thr Thr His Arg Pro Leu His Val Gln Arg Pro Ser 
 1745                1750                1755                1760
Ile Pro Pro Ala Ser Asp Thr Glu Lys Pro Leu Phe Pro Pro Ala Gly 
                 1765                1770                1775
Asn Ser Val Cys His Asn His His Asn His Asn Ser Ile Gly Lys Gln 
             1780                1785                1790
Val Pro Thr Ser Thr Asn Ala Asn Leu Asn Asn Ala Asn Met Ser Lys 
         1795                1800                1805
Ala Ala His Gly Lys Arg Pro Ser Ile Gly Asp Leu Glu His Val Ser 
     1810                1815                1820
Glu Asn Gly His Tyr Ser Tyr Lys His Asp Arg Glu Leu Gln Arg Arg 
 1825                1830                1835                1840
Ser Ser Ile Lys Arg Thr Arg Tyr Tyr Glu Thr Tyr Ile Arg Ser Glu 
                 1845                1850                1855
Ser Gly Asp Glu Gln Leu Pro Thr Ile Phe Arg Glu Asp Pro Glu Ile 
             1860                1865                1870
His Gly Tyr Phe Arg Asp Pro Arg Cys Phe Gly Glu Gln Glu Tyr Phe 
         1875                1880                1885
Ser Ser Glu Glu Cys Cys Glu Asp Asp Ser Ser Pro Thr Trp Ser Arg 
     1890                1895                1900
Gln Asn Tyr Ser Tyr Tyr Asn Arg Tyr Pro Gly Ser Ser Met Asp Phe 
 1905                1910                1915                1920
Glu Arg Pro Arg Gly Tyr His His Pro Gln Gly Phe Leu Glu Asp Asp 
                 1925                1930                1935
Asp Ser Pro Ile Gly Tyr Asp Ser Arg Arg Ser Pro Arg Arg Arg Leu 
             1940                1945                1950
Leu Pro Pro Thr Pro Pro Ser His Arg Arg Ser Ser Phe Asn Phe Glu 
         1955                1960                1965
Cys Leu Arg Arg Gln Asn Ser Gln Asp Asp Val Leu Pro Ser Pro Ala 
     1970                1975                1980
Leu Pro His Arg Ala Ala Leu Pro Leu His Leu Met Gln Gln Gln Ile 
 1985                1990                1995                2000
Met Ala Val Ala Gly Leu Asp Ser Ser Lys Ala Gln Lys Tyr Ser Pro 
                 2005                2010                2015
Ser His Ser Thr Arg Ser Trp Ala Thr Pro Pro Ala Thr Pro Pro Tyr 
             2020                2025                2030
Arg Asp Trp Thr Pro Cys Tyr Thr Pro Leu Ile Gln Val Asp Arg Ser 
         2035                2040                2045
Glu Ser Met Asp Gln Val Asn Gly Ser Leu Pro Ser Leu His Arg Ser 
     2050                2055                2060
Ser Trp Tyr Thr Asp Glu Pro Asp Ile Ser Tyr Arg Thr Phe Thr Pro 
 2065                2070                2075                2080
Ala Ser Leu Thr Val Pro Ser Ser Phe Arg Asn Lys Asn Ser Asp Lys 
                 2085                2090                2095
Gln Arg Ser Ala Asp Ser Leu Val Glu Ala Val Leu Ile Ser Glu Gly 
             2100                2105                2110
Leu Gly Arg Tyr Ala Arg Asp Pro Lys Phe Val Ser Ala Thr Lys His 
         2115                2120                2125
Glu Ile Ala Asp Ala Cys Asp Leu Thr Ile Asp Glu Met Glu Ser Ala 
     2130                2135                2140
Ala Ser Thr Leu Leu Asn Gly Ser Val Cys Pro Arg Ala Asn Gly Asp 
 2145                2150                2155                2160
Met Gly Pro Ile Ser His Arg Gln Asp Tyr Glu Leu Gln Asp Phe Gly 
                 2165                2170                2175
Pro Gly Tyr Ser Asp Glu Glu Pro Asp Pro Gly Arg Glu Glu Glu Asp 
             2180                2185                2190
Leu Ala Asp Glu Met Ile Cys Ile Thr Thr Leu 
         2195                2200



<210> 8128
<211> 7635
<212> DNA
<213> Homo sapiens
<308> M76558
<400> 8128

gggcgagcg  ctccgtccc  ggatgtgag  tccggctgc  cgcggtccc  agccagcgg  60
gcgcgggcg  cggcggcgg  caccgggca  cgcggcggg  gggcagacg  gcgggcatg  120
ggggagcgc  gagcggccc  ggcggccgg  ccggcatca  cgcggcgtc  ctccgctag  180
ggaggggac  agccagttc  cctttgcag  aaaaaatta  atgtatata  tattaagat  240
atatataca  tggatttta  ttttttaaa  agtttattt  gctccattt  tgaaaaaga  300
agagcttgg  tggcgagcg  ttttttttt  aaatcaatt  tccttattt  ctgttattt  360
tccccgtcc  tccccaccc  cctgctgaa  cgagaataa  ggcagggac  gcggctcct  420
cctcttggt  atccccttc  ccattccgc  cccgcccca  cgcccagca  agtgccctg  480
acacagtag  cgctcaata  atgttcgtg  atgatgatg  tgatgatga  gaaaaaaat  540
cagcatcaa  ggcagcagc  agcggacca  gcgaacgag  caaactatg  aagaggcac  600
agacttcct  tttctggtg  aggaccaac  tctcagccg  atagctcca  gcaaactgt  660
ctgtcttgg  aagctgcaa  cgatgctgc  agacaggcc  aggctgccc  aactatgag  720
acctctgca  ccccacctg  aggatctct  tcccaaaga  aacgtcagc  atacgccaa  780
agcaaaaaa  agggtaact  gtccaacag  cgacctgcc  gcgcccttt  ctgtttatc  840
ctcaataac  ccatccgaa  agcctgcat  agtatagtg  aatggaaac  atttgacat  900
tttatatta  tggctattt  tgccaattg  gtggcctta  ctatttaca  cccattccc  960
gaagatgat  ctaattcaa  aaatcataa  ttggaaaaa  tagaatatg  cttcctgat  1020
atttttaca  tcgagacat  tttgaagat  atagcgtat  gattattgc  acatcctaa  1080
gcttatgtt  ggaatggat  gaatttact  gattttgtt  tagtaatag  aggattgtt  1140
agtgtaatt  tggaacaat  aaccaaaga  acagaaggc  ggaaccact  aagcggcaa  1200
tctggaggc  ttgatgtca  agccctccg  gcctttcga  tgttgcgac  acttcgact  1260
gtgtcagga  tgcccagtt  acaagttgt  ctgaactcc  ttataaaag  catggttcc  1320
ctccttcac  tagcccttt  ggtattatt  gtaatcata  tctatgcta  tataggatt  1380
gaacttttt  ttggaaaaa  gcacaaaac  tgttttttt  ctgactcag  tatcgtagc  1440
gaagaggac  cagctccat  tgcgttctc  gggaatgga  gccagtgta  tgccaatgg  1500
acggaatgt  ggagtggct  ggttggccc  aacggaggc  tcaccaact  tgataactt  1560
gcctttgcc  tgcttactg  gtttcagtg  atcaccatg  agggctgga  agacgtgct  1620
tactggatg  atgatgcta  gggatttga  ttgccctgg  tgtattttg  cagtctcgt  1680
atctttggg  catttttcg  actaaatct  gtacttggt  tattgagcg  agaattctc  1740
aaggaaaga  agaaggcaa  agcacgggg  gatttccag  agctccggg  gaagcagca  1800
ctggaggag  atctaaagg  ctacttgga  tggatcacc  aagctgagg  catcgatcc  1860
gagaatgag  aagaaggag  agaggaagg  aaacgaaat  ctagcatgc  caccagcga  1920
actgagtct  tgaacacag  gaacgtcag  ggtgaaggc  agaaccgag  ctgctgtgg  1980
agtctctgt  aagccatct  aaaatccaa  ctcagccga  gctggcgtc  ctggaaccg  2040
ttcaatcgc  gaagatgta  ggccgccgt  aagtctgtc  cgttttact  gctggttat  2100
gtcctggtg  ttctgaaca  cttaaccat  tcctctgag  actacaatc  gccagattg  2160
ttgacacag  ttcaagata  tgccaacaa  gtcctcttg  ctctgttca  ctgcgagat  2220
ctggtaaaa  tgtacagct  gggcctcca  gcatatttc  tctctcttt  caaccggtt  2280
gattgcttc  tggtgtgtg  tggaatcac  gagacgatc  tggtggaac  ggaaatcat  2340
tctcccctg  ggatctctg  gtttcggtg  gtgcgcctc  taagaatct  caaagtgac  2400
aggcactgg  cttccctgt  caacttagt  gcatcctta  taaactcca  gaagtccag  2460
gcttcgctg  tgcttctgc  ttttctctt  attatcatc  tttccttgc  tgggatgca  2520
ctgtttggc  gcaagttta  ttttgatga  acgcaaacc  agcggagca  ctttgacaa  2580
ttccctcaa  cacttctca  agtgttcca  atcctgaca  gcgaagact  gaatgctgt  2640
atgtacgat  gcatcatgg  ttacggggg  ccatcctct  caggaatga  cgtctgcat  2700
tacttcatc  tcctcttca  ttgtggtaa  tatattcta  tgaatgtct  cttggccat  2760
gctgtagac  atttggctg  tgctgaaag  ctgaacact  ctcagaaag  agaagcgga  2820
gaaaaggag  ggaaaaaga  tgccagaaa  gagagccta  aaaataaaa  gaacaacaa  2880
ccagaagtc  accagatag  caacagtga  aacaaggtt  caattgatg  ctatagaga  2940
gaggatgaa  acaaggacc  ctatccgcc  tgcgatgtg  cagtagggg  agaggaaga  3000
gaagaggag  aggatgaac  tgaggttcc  gccggaccc  gtcctcgaa  gatctcgga  3060
ttgaacatg  aggaaaaaa  tgcccccat  cctgaaggg  gcgctttct  cattcttag  3120
aagaccaac  cgatccgcg  aggctgcca  aagctcatc  accaccaca  cttcaccaa  3180
ctcatcctt  tcttcatca  gctgagcag  gctgccctg  ccgcagagg  ccccatccg  3240
agccactcc  tccggaaca  gatactggg  tactttgac  atgccttca  agccatctt  3300
actgttgag  tcctgttga  gatgacaac  tttggagct  tcctccaca  aggggcctt  3360
tgcaggaac  acttcaatt  gctggatat  ctggtggtt  gggtgtctc  ggtgtcatt  3420
gggattcaa  ccagtgcca  ctccgttgt  aagattctg  gggtcttaa  ggtcctgcg  3480
cccctcagg  ccatcaaca  agcaaaagg  cttaagcac  tggtccagt  cgtcttcgt  3540
gccatccgg  ccatcggca  catcatgat  gtcaccacc  tcctgcagt  catgtttgc  3600
tgtatcggg  tccagttgt  caaggggaa  ttctatcgc  gtacggatg  agccaaaag  3660
aaccctgaa  aatgcaggg  acttttcat  ctctacaag  atggggatg  tgacagtcc  3720
gtggtccgt  aacggatct  gcaaaacag  gatttcaac  tcgacaacg  cctctctgc  3780
atgatggcg  tcttcacag  ctccacgtt  gagggctgg  ctgcgttgc  gtataaagc  3840
atcgactcg  atggagaga  catcggccc  atctacaac  accgcgtgg  gatctccat  3900
ttcttcatc  tctacatca  cattgtagc  ttcttcatg  tgaacatct  tgtgggctt  3960
gtcatcgtt  catttcagg  acaaggaga  aaagagtat  agaactgtg  gctggacaa  4020
aatcagcgt  agtgtgttg  atacgcctt  aaagcacgt  ccttgcgga  atacatccc  4080
aaaaacccc  accagtaca  gttctggta  gtggtgaac  cttcgcctt  cgaatacat  4140
atgtttgtc  tcatcatgc  caacacact  tgcttggcc  tgcagcact  cgagcagtc  4200
aagatgttc  atgatgcca  ggacattct  aacatggtc  tcaccgggg  gttcaccgt  4260
gagatggtt  tgaaagtca  cgcatttaa  cctaagggg  attttagtg  cgcctggaa  4320
acgtttgac  ccctcatcg  aatcggcag  attatagac  tggccctca  cgaagcaga  4380
ccaactgaa  gtgaaaatg  ccctgtccc  actgctaca  ctgggaact  tgaagagag  4440
aatagaatc  ccatcacct  tttccgtct  ttccgagtg  tgcgattgg  gaagcttct  4500
agcaggggg  aaggcatcc  gacattgct  tggactttt  ttaagttct  tcaggcgct  4560
ccgtatgtg  ccctcctca  agccatgct  ttcttcatc  atgcggtca  tggcatgca  4620
atgtttggg  aagttgcca  gagagataa  aaccagatc  ataggaaca  taacttcca  4680
acgtttccc  aggcggtgc  gctgctctt  aggtgtgca  caggtgagg  ctggcagga  4740
atcatgctg  cctgtctcc  agggaagct  tgtgaccct  agtcagatt  caaccccgg  4800
gaggagcat  catgtggga  caactttgc  attgtctat  tcatcagtt  ttacatgct  4860
tgtgcattt  tgatcatca  tctgtttgt  gctgtcatc  tggataatt  cgactatct  4920
acccgggac  ggtctattt  ggggcctca  catttagat  aattcaaaa  aatatggtc  4980
gaatatgac  ctgaggcaa  gggaaggat  aaacacctt  atgtggtca  tctgcttcg  5040
cgcatccag  ctcccctgg  gtttgggaa  ttatgtcca  acagggtag  gtgcaagag  5100
ttagttgcc  tgaacatgc  tctcaacag  gacgggaca  tcatgttta  tgcaaccct  5160
tttgctttg  ttcgaacgg  tcttaagat  aagaccgaa  ggaacctgg  gcaagctaa  5220
gaagaactt  gggctgtga  aaagaaaat  tggaagaaa  ccagcatga  attacttga  5280
caagttgtc  ctccagctg  tgatgatga  gtaaccgtg  ggaagttct  tgccacttt  5340
ctgatacag  actacttta  gaaattcaa  aaacggaaa  aacaaggac  ggtgggaaa  5400
taccctgcg  agaacacca  aattgccct  caggcggga  taaggacac  gcatgacat  5460
gggccagaa  tccggcgtg  tatatcgtg  gatttgcaa  atgacgagc  tgaggaaac  5520
aaacgagaa  aagaagatg  tgtgttcaa  agaaatggt  ccctgcttg  aaaccatgt  5580
aatcatgtt  atagtgata  gagagattc  cttcagcag  ccaatacca  ccaccgtcc  5640
ctgcatgtc  aaaggcctt  aattccacc  gcaagtgat  ctgagaaac  gctgtttcc  5700
ccagcagga  attcggtgt  tcataacca  cataaccat  attccatag  aaagcaagt  5760
cccacctca  caaatgcca  tctcaataa  gccaatatg  ccaaagctg  ccatggaaa  5820
cggcccagc  ttgggaacc  tgagcatgt  tctgaaaat  ggcatcatt  ttcccacaa  5880
catgaccgg  agcctcaga  aaggtccag  gtgaaaaga  cccgctatt  tgaaactta  5940
attaggtcc  actcaggag  tgaacagct  ccaactatt  gccgggaag  cccagagat  6000
catggctat  tcagggacc  ccactgctt  ggggagcag  agtatttca  tagtgagga  6060
tgctacgag  atgacagct  gcccacctg  agcaggcaa  actatggct  ctacagcag  6120
tacccaggc  gaaacatcg  ctctgagag  ccccgaggc  accatcatc  ccaaggatt  6180
ttggaggac  atgactcgc  cgtttgcta  gattcacgg  gatctccaa  gagacgcct  6240
ctacctccc  ccccagcat  ccaccggag  tcctccttc  actttgagt  cctgcgccg  6300
cagagcagc  aggaagagg  cccgtcgtc  cccatcttc  cccatcgca  ggccctgcc  6360
ctgcatcta  tgcagcaac  gatcatggc  gttgccggc  tagattcaa  taaagccca  6420
aagtactca  cgagtcact  gacccggtc  tgggccacc  ctccagcaa  ccctcccta  6480
cgggactgg  caccgtgct  cacccccct  atccaagtg  agcagtcag  ggccctgga  6540
caggtgaac  gcagcctgc  gtccctgca  cgcagctcc  ggtacacag  cgagcccga  6600
atctcctac  ggactttca  accagccag  ctgactgtc  ccagcagct  ccggaacaa  6660
aacagcgac  agcagagga  tgcggacag  ttggtggag  cagtcctga  atccgaagg  6720
ttgggacgc  atgcaaggg  cccaaaatt  gtgtcagca  caaaacacg  aatcgctga  6780
gcctgtgac  tcaccatcg  cgagatgga  agtgcagcc  gcaccctgc  taatgggaa  6840
gtgcgtccc  gagccaacg  ggatgtggg  cccctctca  accggcagg  ctatgagct  6900
caggacttt  gtcctggct  cagcgacga  gagccagac  ctgggaggg  tgaggagga  6960
ctggcggat  aaatgatat  catcaccac  ttgtagccc  cagcgaggg  cagactggc  7020
ctggcctca  gtggggcgc  ggagagcca  gggaaaagt  cctcatagt  aggaaagtt  7080
aggcactag  tgggagtaa  attcaatta  ttagacttt  gtataagag  tgtcatgcc  7140
caagaaagc  ataaacctg  taggaacag  tcccaagcg  ttgagcctg  cagagtacc  7200
tgcgctcgg  cccagctgc  ggaaacagc  ggccccgcc  tctcacaga  gatgggtga  7260
gaggccaga  ctgccctgc  ccattgtcc  gatgggcac  gctgtggag  ctgcttctc  7320
catgtacca  ggcaccagg  ccacccaac  gaaggcatg  cggcggggt  caggggaaa  7380
ttaaaggtg  tgacgatca  cacacctgt  tcgttacct  agccatcgg  ctagcatat  7440
agtcactgg  cccaacata  ccattttta  accctttcc  ccaaataca  tgcgtcctg  7500
ttcctgttt  gctgttctg  aatacggtg  gtaagtaag  cagaaccca  ctaccagtg  7560
ttattgcga  ggcaatggg  cctcataaa  aaggttttc  gtgatgtga  gccagttta  7620
ataagagaa  atcac  7635



<210> 8129
<211> 2161
<212> PRT
<213> Homo sapiens
<308> Q01668
<400> 8129

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
  1               5                  10                  15
Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
             20                  25                  30
Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
         35                  40                  45
Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
     50                  55                  60
Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
 65                  70                  75                  80
Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                 85                  90                  95
Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
             100                105                110
Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
         115                120                125
Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
     130                135                140
Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
 145                150                155                160
Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                 165                170                175
Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
             180                185                190
Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
         195                200                205
Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
     210                215                220
Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
 225                230                235                240
Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                 245                250                255
Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
             260                265                270
His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
         275                280                285
Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
     290                295                300
Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
 305                310                315                320
Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                 325                330                335
Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
             340                345                350
Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
         355                360                365
Val Leu Tyr Trp Met Asn Asp Ala Met Gly Phe Glu Leu Pro Trp Val 
     370                375                380
Tyr Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu 
 385                390                395                400
Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                 405                410                415
Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
             420                425                430
Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
         435                440                445
Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
     450                455                460
Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
 465                470                475                480
Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile 
                 485                490                495
Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn 
             500                505                510
Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr Phe Tyr Trp Leu 
         515                520                525
Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile Ser Ser Glu His 
     530                535                540
Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp Ile Ala Asn Lys 
 545                550                555                560
Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val Lys Met Tyr Ser 
                 565                570                575
Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys 
             580                585                590
Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu Val Glu Leu Glu 
         595                600                605
Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu 
     610                615                620
Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu Cys Asn Leu Val 
 625                630                635                640
Ala Ser Leu Leu Asn Ser Met Lys Ser Ser Ala Ser Leu Leu Leu Leu 
                 645                650                655
Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe 
             660                665                670
Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys Arg Ser Thr Phe 
         675                680                685
Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly 
     690                695                700
Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly 
 705                710                715                720
Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe 
                 725                730                735
Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
             740                745                750
Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala Gln Lys Glu Glu 
         755                760                765
Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu 
     770                775                780
Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp 
 785                790                795                800
Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp 
                 805                810                815
Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu 
             820                825                830
Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile 
         835                840                845
Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser 
     850                855                860
Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg Val Gly Cys His 
 865                870                875                880
Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile Leu Val Phe Ile 
                 885                890                895
Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His 
             900                905                910
Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr Ala 
         915                920                925
Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr Phe Gly Ala Phe 
     930                935                940
Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met 
 945                950                955                960
Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala 
                 965                970                975
Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
             980                985                990
Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys Val 
         995                1000                1005
Phe Val Ala Ile Arg Thr Ile Gly Asn Ile Met Ile Val Thr Thr Leu 
     1010                1015                1020
Leu Gln Phe Met Phe Ala Cys Ile Gly Val Gln Leu Phe Lys Gly Lys 
 1025                1030                1035                1040
Phe Tyr Arg Cys Thr Asp Glu Ala Lys Ser Asn Pro Glu Glu Cys Arg 
                 1045                1050                1055
Gly Leu Phe Ile Leu Tyr Lys Asp Gly Asp Val Asp Ser Pro Val Val 
             1060                1065                1070
Arg Glu Arg Ile Trp Gln Asn Ser Asp Phe Asn Phe Asp Asn Val Leu 
         1075                1080                1085
Ser Ala Met Met Ala Leu Phe Thr Val Ser Thr Phe Glu Gly Trp Pro 
     1090                1095                1100
Ala Leu Leu Tyr Lys Ala Ile Asp Ser Asn Gly Glu Asn Ile Gly Pro 
 1105                1110                1115                1120
Ile Tyr Asn His Arg Val Glu Ile Ser Ile Phe Phe Ile Ile Tyr Ile 
                 1125                1130                1135
Ile Ile Val Ala Phe Phe Met Met Asn Ile Phe Val Gly Phe Val Ile 
             1140                1145                1150
Val Thr Phe Gln Glu Gln Gly Glu Lys Glu Tyr Lys Asn Cys Glu Leu 
         1155                1160                1165
Asp Lys Asn Gln Arg Gln Cys Val Glu Tyr Ala Leu Lys Ala Arg Pro 
     1170                1175                1180
Leu Arg Arg Tyr Ile Pro Lys Asn Pro Tyr Gln Tyr Lys Phe Trp Tyr 
 1185                1190                1195                1200
Val Val Asn Ser Ser Pro Phe Glu Tyr Met Met Phe Val Leu Ile Met 
                 1205                1210                1215
Leu Asn Thr Leu Cys Leu Ala Met Gln His Tyr Glu Gln Ser Lys Met 
             1220                1225                1230
Phe Asn Asp Ala Met Asp Ile Leu Asn Met Val Phe Thr Gly Val Phe 
         1235                1240                1245
Thr Val Glu Met Val Leu Lys Val Ile Ala Phe Lys Pro Lys Gly Tyr 
     1250                1255                1260
Phe Ser Asp Ala Trp Asn Thr Phe Asp Ser Leu Ile Val Ile Gly Ser 
 1265                1270                1275                1280
Ile Ile Asp Val Ala Leu Ser Glu Ala Asp Pro Thr Glu Ser Glu Asn 
                 1285                1290                1295
Val Pro Val Pro Thr Ala Thr Pro Gly Asn Ser Glu Glu Ser Asn Arg 
             1300                1305                1310
Ile Ser Ile Thr Phe Phe Arg Leu Phe Arg Val Met Arg Leu Val Lys 
         1315                1320                1325
Leu Leu Ser Arg Gly Glu Gly Ile Arg Thr Leu Leu Trp Thr Phe Ile 
     1330                1335                1340
Lys Phe Phe Gln Ala Leu Pro Tyr Val Ala Leu Leu Ile Ala Met Leu 
 1345                1350                1355                1360
Phe Phe Ile Tyr Ala Val Ile Gly Met Gln Met Phe Gly Lys Val Ala 
                 1365                1370                1375
Met Arg Asp Asn Asn Gln Ile Asn Arg Asn Asn Asn Phe Gln Thr Phe 
             1380                1385                1390
Pro Gln Ala Val Leu Leu Leu Phe Arg Cys Ala Thr Gly Glu Ala Trp 
         1395                1400                1405
Gln Glu Ile Met Leu Ala Cys Leu Pro Gly Lys Leu Cys Asp Pro Glu 
     1410                1415                1420
Ser Asp Tyr Asn Pro Gly Glu Glu His Thr Cys Gly Ser Asn Phe Ala 
 1425                1430                1435                1440
Ile Val Tyr Phe Ile Ser Phe Tyr Met Leu Cys Ala Phe Leu Ile Ile 
                 1445                1450                1455
Asn Leu Phe Val Ala Val Ile Met Asp Asn Phe Asp Tyr Leu Thr Arg 
             1460                1465                1470
Asp Trp Ser Ile Leu Gly Pro His His Leu Asp Glu Phe Lys Arg Ile 
         1475                1480                1485
Trp Ser Glu Tyr Asp Pro Glu Ala Lys Gly Arg Ile Lys His Leu Asp 
     1490                1495                1500
Val Val Thr Leu Leu Arg Arg Ile Gln Pro Pro Leu Gly Phe Gly Lys 
 1505                1510                1515                1520
Leu Cys Pro His Arg Val Ala Cys Lys Arg Leu Val Ala Met Asn Met 
                 1525                1530                1535
Pro Leu Asn Ser Asp Gly Thr Val Met Phe Asn Ala Thr Leu Phe Ala 
             1540                1545                1550
Leu Val Arg Thr Ala Leu Lys Ile Lys Thr Glu Gly Asn Leu Glu Gln 
         1555                1560                1565
Ala Asn Glu Glu Leu Arg Ala Val Ile Lys Lys Ile Trp Lys Lys Thr 
     1570                1575                1580
Ser Met Lys Leu Leu Asp Gln Val Val Pro Pro Ala Gly Asp Asp Glu 
 1585                1590                1595                1600
Val Thr Val Gly Lys Phe Tyr Ala Thr Phe Leu Ile Gln Asp Tyr Phe 
                 1605                1610                1615
Arg Lys Phe Lys Lys Arg Lys Glu Gln Gly Leu Val Gly Lys Tyr Pro 
             1620                1625                1630
Ala Lys Asn Thr Thr Ile Ala Leu Gln Ala Gly Leu Arg Thr Leu His 
         1635                1640                1645
Asp Ile Gly Pro Glu Ile Arg Arg Ala Ile Ser Cys Asp Leu Gln Asp 
     1650                1655                1660
Asp Glu Pro Glu Glu Thr Lys Arg Glu Glu Glu Asp Asp Val Phe Lys 
 1665                1670                1675                1680
Arg Asn Gly Ala Leu Leu Gly Asn His Val Asn His Val Asn Ser Asp 
                 1685                1690                1695
Arg Arg Asp Ser Leu Gln Gln Thr Asn Thr Thr His Arg Pro Leu His 
             1700                1705                1710
Val Gln Arg Pro Ser Ile Pro Pro Ala Ser Asp Thr Glu Lys Pro Leu 
         1715                1720                1725
Phe Pro Pro Ala Gly Asn Ser Val Cys His Asn His His Asn His Asn 
     1730                1735                1740
Ser Ile Gly Lys Gln Val Pro Thr Ser Thr Asn Ala Asn Leu Asn Asn 
 1745                1750                1755                1760
Ala Asn Met Ser Lys Ala Ala His Gly Lys Arg Pro Ser Ile Gly Asn 
                 1765                1770                1775
Leu Glu His Val Ser Glu Asn Gly His His Ser Ser His Lys His Asp 
             1780                1785                1790
Arg Glu Pro Gln Arg Arg Ser Ser Val Lys Arg Thr Arg Tyr Tyr Glu 
         1795                1800                1805
Thr Tyr Ile Arg Ser Asp Ser Gly Asp Glu Gln Leu Pro Thr Ile Cys 
     1810                1815                1820
Arg Glu Asp Pro Glu Ile His Gly Tyr Phe Arg Asp Pro His Cys Leu 
 1825                1830                1835                1840
Gly Glu Gln Glu Tyr Phe Ser Ser Glu Glu Cys Tyr Glu Asp Asp Ser 
                 1845                1850                1855
Ser Pro Thr Trp Ser Arg Gln Asn Tyr Gly Tyr Tyr Ser Arg Tyr Pro 
             1860                1865                1870
Gly Arg Asn Ile Asp Ser Glu Arg Pro Arg Gly Tyr His His Pro Gln 
         1875                1880                1885
Gly Phe Leu Glu Asp Asp Asp Ser Pro Val Cys Tyr Asp Ser Arg Arg 
     1890                1895                1900
Ser Pro Arg Arg Arg Leu Leu Pro Pro Thr Pro Ala Ser His Arg Arg 
 1905                1910                1915                1920
Ser Ser Phe Asn Phe Glu Cys Leu Arg Arg Gln Ser Ser Gln Glu Glu 
                 1925                1930                1935
Val Pro Ser Ser Pro Ile Phe Pro His Arg Thr Ala Leu Pro Leu His 
             1940                1945                1950
Leu Met Gln Gln Gln Ile Met Ala Val Ala Gly Leu Asp Ser Ser Lys 
         1955                1960                1965
Ala Gln Lys Tyr Ser Pro Ser His Ser Thr Arg Ser Trp Ala Thr Pro 
     1970                1975                1980
Pro Ala Thr Pro Pro Tyr Arg Asp Trp Thr Pro Cys Tyr Thr Pro Leu 
 1985                1990                1995                2000
Ile Gln Val Glu Gln Ser Glu Ala Leu Asp Gln Val Asn Gly Ser Leu 
                 2005                2010                2015
Pro Ser Leu His Arg Ser Ser Trp Tyr Thr Asp Glu Pro Asp Ile Ser 
             2020                2025                2030
Tyr Arg Thr Phe Thr Pro Ala Ser Leu Thr Val Pro Ser Ser Phe Arg 
         2035                2040                2045
Asn Lys Asn Ser Asp Lys Gln Arg Ser Ala Asp Ser Leu Val Glu Ala 
     2050                2055                2060
Val Leu Ile Ser Glu Gly Leu Gly Arg Tyr Ala Arg Asp Pro Lys Phe 
 2065                2070                2075                2080
Val Ser Ala Thr Lys His Glu Ile Ala Asp Ala Cys Asp Leu Thr Ile 
                 2085                2090                2095
Asp Glu Met Glu Ser Ala Ala Ser Thr Leu Leu Asn Gly Asn Val Arg 
             2100                2105                2110
Pro Arg Ala Asn Gly Asp Val Gly Pro Leu Ser His Arg Gln Asp Tyr 
         2115                2120                2125
Glu Leu Gln Asp Phe Gly Pro Gly Tyr Ser Asp Glu Glu Pro Asp Pro 
     2130                2135                2140
Gly Arg Asp Glu Glu Asp Leu Ala Asp Glu Met Ile Cys Ile Thr Thr 
 2145                2150                2155                2160
Leu 
                 2165



<210> 8130
<211> 2060
<212> DNA
<213> Rattus norvegicus
<308> U14398
<400> 8130

gctgcagga  ttccctctt  ctttcaatc  gtgaaattg  ccttccggt  aagaggctg  60
aatctccca  taagacgag  agacccaac  ggaacaggg  agggtggca  attgctgat  120
gagagcgcg  accttcctc  agcccctcc  gctgccgct  ccggtcccc  gatcccccg  180
gtttcccct  gaagccttg  ttcagggtc  ttccaggtg  atctgcctg  agttctttc  240
gcacctcgg  cagagcacg  agaaaacat  gctcctatc  ccaccagcc  cgtggaatt  300
gatgaaatt  ccacagtgg  gggcatctt  agtgctttt  gcctggtct  cactgtgtc  360
ctctttgcc  ggatctgct  ccagagaag  tccgctaag  ccaacaaga  tcctccata  420
aagtttgtg  acgtgctta  aggagttga  atctaccca  aaaacctaa  tagcaaaaa  480
aagtttgga  gagatgaca  gagtgaagc  aagcgtaaa  cagctttgc  taacctttc  540
ctgcacctt  atctcgaga  gcgagacct  aatggcaat  tccccaaaa  caaccccaa  600
gctggcagc  cttctgatc  ggaaaatgt  accccaaag  tctttccgg  gacggaaaa  660
gaggccgtc  cccctgaga  cttgaagtc  agcacttcc  tcacttcag  ggagaaaca  720
gagaagctg  gcactctct  cttgtctct  gagtacaac  tcgagaaga  agcatttgt  780
gtgaacatc  aggaagccc  gggcttacc  gccatggat  aacaatcca  gacctctga  840
ccatacatc  agatgacaa  cttaccaga  aagaagcac  aagtgaaaa  cagagtgct  900
aggaagacg  tggaccccg  gtttgacga  accttcaca  tctatgggg  cccttatcc  960
cacatccaa  agctgtccc  gcacttcac  gtcctgagt  ttgacaggt  ctcaagaga  1020
gatgtcatt  gagaagtcc  cgttcctct  tcagggatt  aattgtcag  cgggaaaat  1080
ttaatgacc  gagagatca  caagagaaa  gctaagaag  cttctggac  gggtgaact  1140
ctggtctcc  tctgttatc  gtccactac  aacacgctc  ctgtggttg  cttaaaagc  1200
cggcaccta  cgaaatctg  tgtgtctgg  ctttcagat  cctacgtca  agtgaacct  1260
taccatgcc  agaagagaa  ctctaaaaa  aagactcac  tgaaaaagt  cactcccaa  1320
gcagtgttc  acgaactgt  tgtctttga  attccttgt  agagtcttg  agaaataag  1380
gttgaattt  tagttttgg  ttctgaaag  ggatcccga  atgaggtga  cgggcggtt  1440
gtcctgggt  ccacagcag  aggaagtgg  ggggggcac  ggaaggaga  ctgtgactt  1500
cccaggaga  aaattgcta  gtggcatat  ctctgtgat  gttagcttc  tggccacca  1560
ctacaactt  aaggttttt  ctaggcgag  agcaatttt  tttcttata  gcgattgta  1620
gcttgtggc  cagcaagct  ctttactat  tatttgttt  ggttagaag  ggattaaat  1680
agtagacca  aagatagct  taaatgtgt  ttatgataa  ttcctcttt  attagaggc  1740
ttggccaag  tttcataag  tactgtttc  ctctgtgtg  attaagtgg  ccaaccaag  1800
ctgttatga  cattctagc  taacctcaa  tcacagatg  gtgttgtgg  tgatttcat  1860
ttttgcctt  gtagtggaa  tcaggtgat  gttaagagt  aaaagtggg  aaaaaaaca  1920
acctaagct  gaatttcag  taggaatac  gttgttttt  atataaaaa  ctatcagtg  1980
acaagtgta  tttcaagat  gtctttccc  ctcacagtg  acatggcca  ctaagtttt  2040
taacttact  tttcccaggc  2060



<210> 8131
<211> 425
<212> PRT
<213> Rattus norvegicus
<308> P50232
<400> 8131

Met Ala Pro Ile Thr Thr Ser Arg Val Glu Phe Asp Glu Ile Pro Thr 
  1               5                  10                  15
Val Val Gly Ile Phe Ser Ala Phe Gly Leu Val Phe Thr Val Ser Leu 
             20                  25                  30
Phe Ala Trp Ile Cys Cys Gln Arg Arg Ser Ala Lys Ser Asn Lys Thr 
         35                  40                  45
Pro Pro Tyr Lys Phe Val His Val Leu Lys Gly Val Asp Ile Tyr Pro 
     50                  55                  60
Glu Asn Leu Ser Ser Lys Lys Lys Phe Gly Gly Asp Asp Lys Ser Glu 
 65                  70                  75                  80
Ala Lys Arg Lys Ala Ala Leu Pro Asn Leu Ser Leu His Leu Asp Leu 
                 85                  90                  95
Glu Lys Arg Asp Leu Asn Gly Asn Phe Pro Lys Thr Asn Pro Lys Ala 
             100                105                110
Gly Ser Ser Ser Asp Leu Glu Asn Val Thr Pro Lys Leu Phe Pro Glu 
         115                120                125
Thr Glu Lys Glu Ala Val Ser Pro Glu Ser Leu Lys Ser Ser Thr Ser 
     130                135                140
Leu Thr Ser Glu Glu Lys Gln Glu Lys Leu Gly Thr Leu Phe Leu Ser 
 145                150                155                160
Leu Glu Tyr Asn Phe Glu Lys Lys Ala Phe Val Val Asn Ile Lys Glu 
                 165                170                175
Ala Gln Gly Leu Pro Ala Met Asp Glu Gln Ser Met Thr Ser Asp Pro 
             180                185                190
Tyr Ile Lys Met Thr Ile Leu Pro Glu Lys Lys His Lys Val Lys Thr 
         195                200                205
Arg Val Leu Arg Lys Thr Leu Asp Pro Val Phe Asp Glu Thr Phe Thr 
     210                215                220
Phe Tyr Gly Val Pro Tyr Pro His Ile Gln Glu Leu Ser Leu His Phe 
 225                230                235                240
Thr Val Leu Ser Phe Asp Arg Phe Ser Arg Asp Asp Val Ile Gly Glu 
                 245                250                255
Val Leu Val Pro Leu Ser Gly Ile Glu Leu Ser Asp Gly Lys Met Leu 
             260                265                270
Met Thr Arg Glu Ile Ile Lys Arg Asn Ala Lys Lys Ser Ser Gly Arg 
         275                280                285
Gly Glu Leu Leu Val Ser Leu Cys Tyr Gln Ser Thr Thr Asn Thr Leu 
     290                295                300
Thr Val Val Val Leu Lys Ala Arg His Leu Pro Lys Ser Asp Val Ser 
 305                310                315                320
Gly Leu Ser Asp Pro Tyr Val Lys Val Asn Leu Tyr His Ala Lys Lys 
                 325                330                335
Arg Ile Ser Lys Lys Lys Thr His Val Lys Lys Cys Thr Pro Asn Ala 
             340                345                350
Val Phe Asn Glu Leu Phe Val Phe Asp Ile Pro Cys Glu Ser Leu Glu 
         355                360                365
Glu Ile Ser Val Glu Phe Leu Val Leu Asp Ser Glu Arg Gly Ser Arg 
     370                375                380
Asn Glu Val Ile Gly Arg Leu Val Leu Gly Ala Thr Ala Glu Gly Ser 
 385                390                395                400
Gly Gly Gly His Trp Lys Glu Ile Cys Asp Phe Pro Arg Arg Gln Ile 
                 405                410                415
Ala Lys Trp His Met Leu Cys Asp Gly 
             420                425



<210> 8132
<211> 6471
<212> DNA
<213> Homo sapiens
<308> X96783
<400> 8132

ggcccaggc  ccggtgggc  ccggagcga  cctgccccg  cgggactcc  cgtctgtgc  60
tcagccccg  ccgttgtcc  ggcaacaac  cgttgcccg  gcaaccagc  ttgctctta  120
cccgcttga  aggagcccg  ctgttgctc  gggcaacgc  gtctgctgg  tcccacgtc  180
gccttcgcc  gcttccggt  cagaccctg  ggaggggcg  ggacgaggc  gaagtcagc  240
ggatgcctg  ggggccgtg  aggaagagg  tatcccttt  ggatggaac  aggtcctgg  300
caccccctc  caagtgcgg  gaggctgat  ctacaactc  cagcatgac  cgcggtggc  360
gtccggttt  tgcgcggct  ttcgcgcaa  ggcctcatg  gagttggag  tctttgttg  420
gcgtggggc  caaaggacg  ctggggtgg  aatggggga  tagggtgct  gagtgtctc  480
gcagaaaag  ctccaggac  ccgccacca  gttcccgga  cccccaacc  cggggcctc  540
atcgcccga  acgcctccc  actccagtc  catcagcca  ggcccaggt  agcaagacc  600
gggggtggg  ggccgagca  agagaaagc  tggccagga  tccgagggg  gggattcgg  660
cgggtgtac  cgggcaggc  ggctggaaa  tccggctgg  atcccgggt  gtcatcctg  720
actggaatg  gaacgaaat  gggtaaaag  aaggaacag  tttgcaaaa  aaaaaaaaa  780
aaaaaaaaa  aaaatcgaa  ccggatcaa  gggtgttgc  tggaatggg  tcttagaat  840
ggaaggtcc  cctagctct  cttttacag  taaggaaac  ggcccgatg  ggagcaggg  900
ttcttgtaa  agcatcagg  gttgagcag  aatgggggg  ggggtcggg  aaggaaagg  960
agaactaac  agcaagcaa  yccagatgg  gtcagcctg  gttggggca  cgaatctct  1020
tataggcca  attaggtgg  agaaaaaca  aggaagaaa  gcaatgaaa  tggctggag  1080
gaaaaggag  ccagcattc  agcttccac  tgtaatcag  actgaatca  cctgcgtgc  1140
gcccaggcc  caatgtgtg  tgtctccac  cctctgcag  gcccccctg  gccctggcc  1200
ccatcgtrc  ggtctcagg  ctcctcatc  tcagctgct  tttctgtct  taccggaag  1260
gctgtcgga  gcggacagg  aagaagagc  aggcccaag  ccaggtcca  cttcaggaa  1320
tgaaggggc  gggccagag  tacatagac  aggtgtggc  cagcccagc  cctccacct  1380
gccccttcc  gcaccctgc  cctctcaat  gcccagctg  tcccagtcc  tgctccctt  1440
tgtcctata  gaacccacc  tactggctc  tcctccctg  gtgtctagc  ctcaactgg  1500
ctctgggga  ccagagatg  aacagaact  gttgctatt  ccaagaact  cccagtctg  1560
tgggagagt  aggcactga  acagacact  accacacag  gtaatatgt  ccatactac  1620
gggtctcat  ggagcacag  aaaggcatc  cactgtata  aaacctaca  aaacatata  1680
atatttggc  ctgggccgg  tgcggtggc  cacgcctgt  atcctagca  ttgggaggc  1740
gaggtggac  gattgcctg  ggtcatgaa  tcaagacta  cctgggcaa  atgatgaaa  1800
cctgtctct  ctaaaaata  aaaagccar  catggtggt  tggtataat  ccagctact  1860
gagaggctg  ggcactgaa  ccgggaggt  gaggctgca  tgagctgtg  tcgcgccac  1920
gcactccag  ctgggtgac  gagcgagac  ctgtctcca  taaatagat  aataaataa  1980
tggctctga  agctgaaaa  cagctttgt  ccagaatac  ttaaaatat  ctgattttt  2040
tcagaaaat  ggacatatt  acagtagga  aargtttaa  acagagggt  agacagagg  2100
ggcttcgtg  tggaggtga  ttctgcact  agacctgag  gacagagtt  actgagacc  2160
gagagaagg  cattctagt  caagttgga  catgtgtwg  ggccccata  ccagattca  2220
gccccatat  cagattcyg  ggcttattt  gggaacaaa  agtcatttc  cacaatagc  2280
gcactctgg  gtgaagtgt  tggagaact  agcagtatc  atgtcatga  ggtgatgaa  2340
gctacaaat  tgttttgag  atgagaggg  cagggtcag  tggtgttag  atgactcct  2400
tggaaccct  tgtaggaca  atctgcggc  agggatcca  ggacgaggc  agtgcagca  2460
cagcctgga  aggataaaa  acatttgca  tggatgagg  cgttggaat  gaaagtggt  2520
actgcaggg  ctgaaaatt  agtctctca  tgcagagtg  agtggttgc  tgggagcca  2580
acagcccta  gtttccaac  aagaaggac  atttcctgg  tgtgtgacc  tggagaact  2640
actgtccct  tctgagcct  aagtctgtg  tcactaact  ggtatttcc  ctccttcct  2700
ctcaataag  agctgttca  ttagcatcc  taaaggatg  tatttaggg  cctggtgtc  2760
agccccatc  ctgtccctt  aaccagtga  gttcaaaga  cgtctgcag  agaatcaca  2820
tgggtactt  ttgaaatgc  aattctggc  ctagcacct  acctatcaa  tcagaatcc  2880
tgaagaggt  acctcagac  ttttgccac  ggattcagg  gaattcagg  tcacattga  2940
ttttaagaa  tgctggcct  ggttaagga  acaccttct  ctttttcat  caactttag  3000
atggcaagt  cacagtaaa  atgccattt  tcctccatg  tttgctgtg  taagatcac  3060
agtaaacat  gcagtttgg  ctagcaccc  agtacatcc  ttagcatgt  aaataaaac  3120
tgcattatt  ctgtgggca  tgggacact  tcagcactt  ttttaatct  agcatgaca  3180
gcacatgtc  agttcctgc  catagcaga  accactaat  aaaccttca  aaacatact  3240
catctgtgt  accacgtct  tttcctgcc  gtggcagac  gcactagtc  aatactgaa  3300
ctgcttagc  tgtgagagc  caggtatag  ccaagggac  tgtgagcct  ccttggctt  3360
tgagcctga  ggatactgc  atcagggga  gacttcacc  acccttacc  ctggctcct  3420
aaggtgcag  cagaagtag  ggagctgga  ccagcacca  ccgggccag  gcagcaggt  3480
scagacaag  atgagctag  acgactgca  tactccctg  attatgact  ccagagtgg  3540
caggtgggt  tggaggaag  ggaagcttt  gagggagga  cccgggggt  ccaacccct  3600
ctgaaagga  ccatggaag  gaggctaag  ctagtgttc  ccacctccc  cactgtgcc  3660
gggccctgc  gctgctggt  ggcattctg  aagcaatgg  attggcagc  ttggatctt  3720
gtggctcct  ggaccccta  gtgcgggtc  acctgctgm  ggacaaacg  aggcggtac  3780
agaccaagg  gcatcggca  acgctgaac  ctcactttg  ggagacctt  gccttcaag  3840
tgagctctg  ttcaggccc  gtgttccat  gcctgtgcc  agtccctgg  acactaggg  3900
ccgacccct  ccgcttttc  tggaggcag  cacagctca  gtggcagct  ccagctctg  3960
ggctattcc  ctggaccct  ggcactact  actcctggg  tgtagcctg  tccttgggc  4020
gtacgattt  ggttccact  acccgtgat  tttttccgc  tggatccct  gactttccc  4080
tttgagttc  cccaactgt  cgcttcgac  ctcgctgcc  cactccacg  cttccttct  4140
gttgtgctg  gcctcaccc  atctctgac  tcctgctct  tactgcgga  tctctgtgc  4200
ctccaggtm  cctacgtgg  gctgggggg  agggtgctg  tcatggcgg  gtacgactt  4260
gaccgcttc  ctcgcaatg  cgccatcgg  gaggtgcgg  tccctatga  ctccgtgga  4320
ctggggcgg  cagtgcagg  ctggcggga  ctgcaggcg  ctccgcggg  ggaggtgag  4380
atgcgcggt  gcgccccga  ccacgcccc  aggcccagt  ccgcccaca  catcctgag  4440
caatcagat  ataggcttt  cagaccctc  gggcggcgt  gattgtacc  ctgaggagg  4500
atggatgtg  agccggggc  ctggtgatg  gcccctctc  tttcagcag  agaagcttg  4560
ggacatctg  ttctccctc  gctatgtcc  cacggccgg  aagctcacc  tcatcgtcc  4620
ggaggctaa  aacctgaag  agatggacg  aggaggact  tcaggtgtg  gggaagcaa  4680
ggagtgggg  gtgagggga  ggcgtgggg  gggttctcg  tctgacagt  tctgagcct  4740
gagggtttc  tcggggaca  ggaggacct  gctgctgtg  aaggcatgg  ttttggcat  4800
gagctaggg  gacccgaag  gtgtaggca  tgtttctat  ttggtccaa  aacccagca  4860
tggggagct  taagactcc  ccttcctct  cccagatcc  tacgtcaag  tccacctgc  4920
gcagggcgg  aaaaaggtg  ggaagaaga  aaccaccat  aagaagaac  ctctgaacc  4980
ctattacaa  gaagctttc  gcttcgagg  gccctgtga  caagtccag  tgagctcaa  5040
cctgccctt  tccaagagc  cagaccttt  gtaatcgcc  ttgctaggc  gagggagac  5100
ttttagcat  tccctagaa  ccaggtgag  gggtctgag  ttatgctct  agtctgttt  5160
ctcctatga  gaccaggaa  cctcttcca  tccaggaag  gactcctta  aattgggtg  5220
gggtgtcct  tctgctcta  gcgggaccg  gatgctcca  ccctaagcg  aaccaggat  5280
tcccacccc  aagcagtac  agatgctcc  ccctaagca  gatcagtat  ccccgcccc  5340
ccaagcgga  ccaggatgc  ccgccccca  gcaggacca  gatgccccg  ccccaagca  5400
gaccaggat  ccccgcccc  aagcgggac  aggatgccc  actcctaag  gggaccaga  5460
tccccaccc  aagcaggac  aggatgccc  gccctcctc  ggaacgtgg  tctaagaaa  5520
agagacctc  cctcacttc  ttagggacg  cgcctaccc  agcccggcc  ctgttaaag  5580
tctgcagct  tgcggctct  aggaggctg  tcccccagg  ggcgccgaa  acacccgct  5640
cgcaaccga  tcctgaggg  tcatttcct  agaaacctg  ctgcgcagg  agaaaggcg  5700
cagagcctc  tcctcgccg  aggctccgt  cctctcgtc  cccaccccc  cccccgtcc  5760
gagctccgg  gccccgagc  ctcgggtgg  agcgagagg  accctcagc  gtgaaaacg  5820
acaccgccc  ttccggggc  tcctcccct  acgctcctc  ctcctcttc  tcccgcgcc  5880
accccagaa  gtgcaggtg  agctgaccg  gctggacta  gacaagctg  gcaagaacg  5940
ggccatcgg  agggtggcc  tgggggcgg  cgccggcgg  gctggcctg  ggcactggg  6000
ggacatgct  gccaacccg  ggcggccca  tgcccagtg  cactcgctg  ggcccccgg  6060
ccgagtgag  ctgctgcct  cgccctgac  cccacccca  gcccccggc  aagcctgga  6120
tctagcccc  gaccccaga  tcccgagac  ggccaaagc  aagccagcc  cacccttaa  6180
cttcctctg  cggttaccc  ccccccacc  tccacccca  ccatctgaa  cattcctgt  6240
ttctcaccc  caacgatgc  aatcacgac  actttccag  acactcccc  gaccctcgc  6300
gacacaccc  gatgcccca  ggaccccgg  aagggaagg  agcctggtt  ctcctgccc  6360
cgggtcctg  cccctgctt  gacaatcag  catcctcgt  tgctctcct  tctcttcca  6420
cacagccca  ccctgcact  ctcctgagg  caaataaat  ttcagcagc  c  6471



<210> 8133
<211> 386
<212> PRT
<213> Homo sapiens
<308> O00445
<400> 8133

Met Phe Pro Glu Pro Pro Thr Pro Gly Pro Pro Ser Pro Asp Thr Pro 
  1               5                  10                  15
Pro Asp Ser Ser Arg Ile Ser His Gly Pro Val Pro Pro Trp Ala Leu 
             20                  25                  30
Ala Thr Ile Val Leu Val Ser Gly Leu Leu Ile Phe Ser Cys Cys Phe 
         35                  40                  45
Cys Leu Tyr Arg Lys Ser Cys Arg Arg Arg Thr Gly Lys Lys Ser Gln 
     50                  55                  60
Ala Gln Ala Gln Val His Leu Gln Glu Val Lys Gly Leu Gly Gln Ser 
 65                  70                  75                  80
Tyr Ile Asp Lys Val Gln Pro Glu Val Glu Glu Leu Glu Pro Ala Pro 
                 85                  90                  95
Ser Gly Pro Gly Gln Gln Val Xaa Asp Lys His Glu Leu Gly Arg Leu 
             100                105                110
Gln Tyr Ser Leu Asp Tyr Asp Phe Gln Ser Gly Gln Leu Leu Val Gly 
         115                120                125
Ile Leu Gln Ala Met Gly Leu Ala Ala Leu Asp Leu Gly Gly Ser Ser 
     130                135                140
Asp Pro Tyr Val Arg Val Tyr Leu Leu Xaa Asp Lys Arg Arg Arg Tyr 
 145                150                155                160
Glu Thr Lys Val His Arg Gln Thr Leu Asn Pro His Phe Gly Glu Thr 
                 165                170                175
Phe Ala Phe Lys Val Pro Tyr Val Glu Leu Gly Gly Arg Val Leu Val 
             180                185                190
Met Ala Val Tyr Asp Phe Asp Arg Phe Ser Arg Asn Asp Ala Ile Gly 
         195                200                205
Glu Val Arg Val Pro Met Ser Ser Val Asp Leu Gly Arg Pro Val Gln 
     210                215                220
Ala Trp Arg Glu Leu Gln Ala Ala Pro Arg Glu Glu Gln Glu Lys Leu 
 225                230                235                240
Gly Asp Ile Cys Phe Ser Leu Arg Tyr Val Pro Thr Ala Gly Lys Leu 
                 245                250                255
Thr Val Ile Val Leu Glu Ala Lys Asn Leu Lys Lys Met Asp Val Gly 
             260                265                270
Gly Leu Ser Asp Pro Tyr Val Lys Val His Leu Leu Gln Gly Gly Lys 
         275                280                285
Lys Val Arg Lys Lys Lys Thr Thr Ile Lys Lys Asn Thr Leu Asn Pro 
     290                295                300
Tyr Tyr Asn Glu Ala Phe Ser Phe Glu Val Pro Cys Asp Gln Val Gln 
 305                310                315                320
Lys Val Gln Val Glu Leu Thr Val Leu Asp Tyr Asp Lys Leu Gly Lys 
                 325                330                335
Asn Glu Ala Ile Gly Arg Val Ala Val Gly Ala Ala Ala Gly Gly Ala 
             340                345                350
Gly Leu Arg His Trp Ala Asp Met Leu Ala Asn Pro Arg Arg Pro Ile 
         355                360                365
Ala Gln Trp His Ser Leu Arg Pro Pro Asp Arg Val Arg Leu Leu Pro 
     370                375                380
Ala Pro 
 385



<210> 8134
<211> 2060
<212> DNA
<213> Rattus norvegicus
<308> U14398
<400> 8134

gctgcagga  ttccctctt  ctttcaatc  gtgaaattg  ccttccggt  aagaggctg  60
aatctccca  taagacgag  agacccaac  ggaacaggg  agggtggca  attgctgat  120
gagagcgcg  accttcctc  agcccctcc  gctgccgct  ccggtcccc  gatcccccg  180
gtttcccct  gaagccttg  ttcagggtc  ttccaggtg  atctgcctg  agttctttc  240
gcacctcgg  cagagcacg  agaaaacat  gctcctatc  ccaccagcc  cgtggaatt  300
gatgaaatt  ccacagtgg  gggcatctt  agtgctttt  gcctggtct  cactgtgtc  360
ctctttgcc  ggatctgct  ccagagaag  tccgctaag  ccaacaaga  tcctccata  420
aagtttgtg  acgtgctta  aggagttga  atctaccca  aaaacctaa  tagcaaaaa  480
aagtttgga  gagatgaca  gagtgaagc  aagcgtaaa  cagctttgc  taacctttc  540
ctgcacctt  atctcgaga  gcgagacct  aatggcaat  tccccaaaa  caaccccaa  600
gctggcagc  cttctgatc  ggaaaatgt  accccaaag  tctttccgg  gacggaaaa  660
gaggccgtc  cccctgaga  cttgaagtc  agcacttcc  tcacttcag  ggagaaaca  720
gagaagctg  gcactctct  cttgtctct  gagtacaac  tcgagaaga  agcatttgt  780
gtgaacatc  aggaagccc  gggcttacc  gccatggat  aacaatcca  gacctctga  840
ccatacatc  agatgacaa  cttaccaga  aagaagcac  aagtgaaaa  cagagtgct  900
aggaagacg  tggaccccg  gtttgacga  accttcaca  tctatgggg  cccttatcc  960
cacatccaa  agctgtccc  gcacttcac  gtcctgagt  ttgacaggt  ctcaagaga  1020
gatgtcatt  gagaagtcc  cgttcctct  tcagggatt  aattgtcag  cgggaaaat  1080
ttaatgacc  gagagatca  caagagaaa  gctaagaag  cttctggac  gggtgaact  1140
ctggtctcc  tctgttatc  gtccactac  aacacgctc  ctgtggttg  cttaaaagc  1200
cggcaccta  cgaaatctg  tgtgtctgg  ctttcagat  cctacgtca  agtgaacct  1260
taccatgcc  agaagagaa  ctctaaaaa  aagactcac  tgaaaaagt  cactcccaa  1320
gcagtgttc  acgaactgt  tgtctttga  attccttgt  agagtcttg  agaaataag  1380
gttgaattt  tagttttgg  ttctgaaag  ggatcccga  atgaggtga  cgggcggtt  1440
gtcctgggt  ccacagcag  aggaagtgg  ggggggcac  ggaaggaga  ctgtgactt  1500
cccaggaga  aaattgcta  gtggcatat  ctctgtgat  gttagcttc  tggccacca  1560
ctacaactt  aaggttttt  ctaggcgag  agcaatttt  tttcttata  gcgattgta  1620
gcttgtggc  cagcaagct  ctttactat  tatttgttt  ggttagaag  ggattaaat  1680
agtagacca  aagatagct  taaatgtgt  ttatgataa  ttcctcttt  attagaggc  1740
ttggccaag  tttcataag  tactgtttc  ctctgtgtg  attaagtgg  ccaaccaag  1800
ctgttatga  cattctagc  taacctcaa  tcacagatg  gtgttgtgg  tgatttcat  1860
ttttgcctt  gtagtggaa  tcaggtgat  gttaagagt  aaaagtggg  aaaaaaaca  1920
acctaagct  gaatttcag  taggaatac  gttgttttt  atataaaaa  ctatcagtg  1980
acaagtgta  tttcaagat  gtctttccc  ctcacagtg  acatggcca  ctaagtttt  2040
taacttact  tttcccaggc  2060



<210> 8135
<211> 425
<212> PRT
<213> Rattus norvegicus
<308> P50232
<400> 8135

Met Ala Pro Ile Thr Thr Ser Arg Val Glu Phe Asp Glu Ile Pro Thr 
  1               5                  10                  15
Val Val Gly Ile Phe Ser Ala Phe Gly Leu Val Phe Thr Val Ser Leu 
             20                  25                  30
Phe Ala Trp Ile Cys Cys Gln Arg Arg Ser Ala Lys Ser Asn Lys Thr 
         35                  40                  45
Pro Pro Tyr Lys Phe Val His Val Leu Lys Gly Val Asp Ile Tyr Pro 
     50                  55                  60
Glu Asn Leu Ser Ser Lys Lys Lys Phe Gly Gly Asp Asp Lys Ser Glu 
 65                  70                  75                  80
Ala Lys Arg Lys Ala Ala Leu Pro Asn Leu Ser Leu His Leu Asp Leu 
                 85                  90                  95
Glu Lys Arg Asp Leu Asn Gly Asn Phe Pro Lys Thr Asn Pro Lys Ala 
             100                105                110
Gly Ser Ser Ser Asp Leu Glu Asn Val Thr Pro Lys Leu Phe Pro Glu 
         115                120                125
Thr Glu Lys Glu Ala Val Ser Pro Glu Ser Leu Lys Ser Ser Thr Ser 
     130                135                140
Leu Thr Ser Glu Glu Lys Gln Glu Lys Leu Gly Thr Leu Phe Leu Ser 
 145                150                155                160
Leu Glu Tyr Asn Phe Glu Lys Lys Ala Phe Val Val Asn Ile Lys Glu 
                 165                170                175
Ala Gln Gly Leu Pro Ala Met Asp Glu Gln Ser Met Thr Ser Asp Pro 
             180                185                190
Tyr Ile Lys Met Thr Ile Leu Pro Glu Lys Lys His Lys Val Lys Thr 
         195                200                205
Arg Val Leu Arg Lys Thr Leu Asp Pro Val Phe Asp Glu Thr Phe Thr 
     210                215                220
Phe Tyr Gly Val Pro Tyr Pro His Ile Gln Glu Leu Ser Leu His Phe 
 225                230                235                240
Thr Val Leu Ser Phe Asp Arg Phe Ser Arg Asp Asp Val Ile Gly Glu 
                 245                250                255
Val Leu Val Pro Leu Ser Gly Ile Glu Leu Ser Asp Gly Lys Met Leu 
             260                265                270
Met Thr Arg Glu Ile Ile Lys Arg Asn Ala Lys Lys Ser Ser Gly Arg 
         275                280                285
Gly Glu Leu Leu Val Ser Leu Cys Tyr Gln Ser Thr Thr Asn Thr Leu 
     290                295                300
Thr Val Val Val Leu Lys Ala Arg His Leu Pro Lys Ser Asp Val Ser 
 305                310                315                320
Gly Leu Ser Asp Pro Tyr Val Lys Val Asn Leu Tyr His Ala Lys Lys 
                 325                330                335
Arg Ile Ser Lys Lys Lys Thr His Val Lys Lys Cys Thr Pro Asn Ala 
             340                345                350
Val Phe Asn Glu Leu Phe Val Phe Asp Ile Pro Cys Glu Ser Leu Glu 
         355                360                365
Glu Ile Ser Val Glu Phe Leu Val Leu Asp Ser Glu Arg Gly Ser Arg 
     370                375                380
Asn Glu Val Ile Gly Arg Leu Val Leu Gly Ala Thr Ala Glu Gly Ser 
 385                390                395                400
Gly Gly Gly His Trp Lys Glu Ile Cys Asp Phe Pro Arg Arg Gln Ile 
                 405                410                415
Ala Lys Trp His Met Leu Cys Asp Gly 
             420                425



<210> 8136
<211> 6471
<212> DNA
<213> Homo sapiens
<308> X96783
<400> 8136

ggcccaggc  ccggtgggc  ccggagcga  cctgccccg  cgggactcc  cgtctgtgc  60
tcagccccg  ccgttgtcc  ggcaacaac  cgttgcccg  gcaaccagc  ttgctctta  120
cccgcttga  aggagcccg  ctgttgctc  gggcaacgc  gtctgctgg  tcccacgtc  180
gccttcgcc  gcttccggt  cagaccctg  ggaggggcg  ggacgaggc  gaagtcagc  240
ggatgcctg  ggggccgtg  aggaagagg  tatcccttt  ggatggaac  aggtcctgg  300
caccccctc  caagtgcgg  gaggctgat  ctacaactc  cagcatgac  cgcggtggc  360
gtccggttt  tgcgcggct  ttcgcgcaa  ggcctcatg  gagttggag  tctttgttg  420
gcgtggggc  caaaggacg  ctggggtgg  aatggggga  tagggtgct  gagtgtctc  480
gcagaaaag  ctccaggac  ccgccacca  gttcccgga  cccccaacc  cggggcctc  540
atcgcccga  acgcctccc  actccagtc  catcagcca  ggcccaggt  agcaagacc  600
gggggtggg  ggccgagca  agagaaagc  tggccagga  tccgagggg  gggattcgg  660
cgggtgtac  cgggcaggc  ggctggaaa  tccggctgg  atcccgggt  gtcatcctg  720
actggaatg  gaacgaaat  gggtaaaag  aaggaacag  tttgcaaaa  aaaaaaaaa  780
aaaaaaaaa  aaaatcgaa  ccggatcaa  gggtgttgc  tggaatggg  tcttagaat  840
ggaaggtcc  cctagctct  cttttacag  taaggaaac  ggcccgatg  ggagcaggg  900
ttcttgtaa  agcatcagg  gttgagcag  aatgggggg  ggggtcggg  aaggaaagg  960
agaactaac  agcaagcaa  yccagatgg  gtcagcctg  gttggggca  cgaatctct  1020
tataggcca  attaggtgg  agaaaaaca  aggaagaaa  gcaatgaaa  tggctggag  1080
gaaaaggag  ccagcattc  agcttccac  tgtaatcag  actgaatca  cctgcgtgc  1140
gcccaggcc  caatgtgtg  tgtctccac  cctctgcag  gcccccctg  gccctggcc  1200
ccatcgtrc  ggtctcagg  ctcctcatc  tcagctgct  tttctgtct  taccggaag  1260
gctgtcgga  gcggacagg  aagaagagc  aggcccaag  ccaggtcca  cttcaggaa  1320
tgaaggggc  gggccagag  tacatagac  aggtgtggc  cagcccagc  cctccacct  1380
gccccttcc  gcaccctgc  cctctcaat  gcccagctg  tcccagtcc  tgctccctt  1440
tgtcctata  gaacccacc  tactggctc  tcctccctg  gtgtctagc  ctcaactgg  1500
ctctgggga  ccagagatg  aacagaact  gttgctatt  ccaagaact  cccagtctg  1560
tgggagagt  aggcactga  acagacact  accacacag  gtaatatgt  ccatactac  1620
gggtctcat  ggagcacag  aaaggcatc  cactgtata  aaacctaca  aaacatata  1680
atatttggc  ctgggccgg  tgcggtggc  cacgcctgt  atcctagca  ttgggaggc  1740
gaggtggac  gattgcctg  ggtcatgaa  tcaagacta  cctgggcaa  atgatgaaa  1800
cctgtctct  ctaaaaata  aaaagccar  catggtggt  tggtataat  ccagctact  1860
gagaggctg  ggcactgaa  ccgggaggt  gaggctgca  tgagctgtg  tcgcgccac  1920
gcactccag  ctgggtgac  gagcgagac  ctgtctcca  taaatagat  aataaataa  1980
tggctctga  agctgaaaa  cagctttgt  ccagaatac  ttaaaatat  ctgattttt  2040
tcagaaaat  ggacatatt  acagtagga  aargtttaa  acagagggt  agacagagg  2100
ggcttcgtg  tggaggtga  ttctgcact  agacctgag  gacagagtt  actgagacc  2160
gagagaagg  cattctagt  caagttgga  catgtgtwg  ggccccata  ccagattca  2220
gccccatat  cagattcyg  ggcttattt  gggaacaaa  agtcatttc  cacaatagc  2280
gcactctgg  gtgaagtgt  tggagaact  agcagtatc  atgtcatga  ggtgatgaa  2340
gctacaaat  tgttttgag  atgagaggg  cagggtcag  tggtgttag  atgactcct  2400
tggaaccct  tgtaggaca  atctgcggc  agggatcca  ggacgaggc  agtgcagca  2460
cagcctgga  aggataaaa  acatttgca  tggatgagg  cgttggaat  gaaagtggt  2520
actgcaggg  ctgaaaatt  agtctctca  tgcagagtg  agtggttgc  tgggagcca  2580
acagcccta  gtttccaac  aagaaggac  atttcctgg  tgtgtgacc  tggagaact  2640
actgtccct  tctgagcct  aagtctgtg  tcactaact  ggtatttcc  ctccttcct  2700
ctcaataag  agctgttca  ttagcatcc  taaaggatg  tatttaggg  cctggtgtc  2760
agccccatc  ctgtccctt  aaccagtga  gttcaaaga  cgtctgcag  agaatcaca  2820
tgggtactt  ttgaaatgc  aattctggc  ctagcacct  acctatcaa  tcagaatcc  2880
tgaagaggt  acctcagac  ttttgccac  ggattcagg  gaattcagg  tcacattga  2940
ttttaagaa  tgctggcct  ggttaagga  acaccttct  ctttttcat  caactttag  3000
atggcaagt  cacagtaaa  atgccattt  tcctccatg  tttgctgtg  taagatcac  3060
agtaaacat  gcagtttgg  ctagcaccc  agtacatcc  ttagcatgt  aaataaaac  3120
tgcattatt  ctgtgggca  tgggacact  tcagcactt  ttttaatct  agcatgaca  3180
gcacatgtc  agttcctgc  catagcaga  accactaat  aaaccttca  aaacatact  3240
catctgtgt  accacgtct  tttcctgcc  gtggcagac  gcactagtc  aatactgaa  3300
ctgcttagc  tgtgagagc  caggtatag  ccaagggac  tgtgagcct  ccttggctt  3360
tgagcctga  ggatactgc  atcagggga  gacttcacc  acccttacc  ctggctcct  3420
aaggtgcag  cagaagtag  ggagctgga  ccagcacca  ccgggccag  gcagcaggt  3480
scagacaag  atgagctag  acgactgca  tactccctg  attatgact  ccagagtgg  3540
caggtgggt  tggaggaag  ggaagcttt  gagggagga  cccgggggt  ccaacccct  3600
ctgaaagga  ccatggaag  gaggctaag  ctagtgttc  ccacctccc  cactgtgcc  3660
gggccctgc  gctgctggt  ggcattctg  aagcaatgg  attggcagc  ttggatctt  3720
gtggctcct  ggaccccta  gtgcgggtc  acctgctgm  ggacaaacg  aggcggtac  3780
agaccaagg  gcatcggca  acgctgaac  ctcactttg  ggagacctt  gccttcaag  3840
tgagctctg  ttcaggccc  gtgttccat  gcctgtgcc  agtccctgg  acactaggg  3900
ccgacccct  ccgcttttc  tggaggcag  cacagctca  gtggcagct  ccagctctg  3960
ggctattcc  ctggaccct  ggcactact  actcctggg  tgtagcctg  tccttgggc  4020
gtacgattt  ggttccact  acccgtgat  tttttccgc  tggatccct  gactttccc  4080
tttgagttc  cccaactgt  cgcttcgac  ctcgctgcc  cactccacg  cttccttct  4140
gttgtgctg  gcctcaccc  atctctgac  tcctgctct  tactgcgga  tctctgtgc  4200
ctccaggtm  cctacgtgg  gctgggggg  agggtgctg  tcatggcgg  gtacgactt  4260
gaccgcttc  ctcgcaatg  cgccatcgg  gaggtgcgg  tccctatga  ctccgtgga  4320
ctggggcgg  cagtgcagg  ctggcggga  ctgcaggcg  ctccgcggg  ggaggtgag  4380
atgcgcggt  gcgccccga  ccacgcccc  aggcccagt  ccgcccaca  catcctgag  4440
caatcagat  ataggcttt  cagaccctc  gggcggcgt  gattgtacc  ctgaggagg  4500
atggatgtg  agccggggc  ctggtgatg  gcccctctc  tttcagcag  agaagcttg  4560
ggacatctg  ttctccctc  gctatgtcc  cacggccgg  aagctcacc  tcatcgtcc  4620
ggaggctaa  aacctgaag  agatggacg  aggaggact  tcaggtgtg  gggaagcaa  4680
ggagtgggg  gtgagggga  ggcgtgggg  gggttctcg  tctgacagt  tctgagcct  4740
gagggtttc  tcggggaca  ggaggacct  gctgctgtg  aaggcatgg  ttttggcat  4800
gagctaggg  gacccgaag  gtgtaggca  tgtttctat  ttggtccaa  aacccagca  4860
tggggagct  taagactcc  ccttcctct  cccagatcc  tacgtcaag  tccacctgc  4920
gcagggcgg  aaaaaggtg  ggaagaaga  aaccaccat  aagaagaac  ctctgaacc  4980
ctattacaa  gaagctttc  gcttcgagg  gccctgtga  caagtccag  tgagctcaa  5040
cctgccctt  tccaagagc  cagaccttt  gtaatcgcc  ttgctaggc  gagggagac  5100
ttttagcat  tccctagaa  ccaggtgag  gggtctgag  ttatgctct  agtctgttt  5160
ctcctatga  gaccaggaa  cctcttcca  tccaggaag  gactcctta  aattgggtg  5220
gggtgtcct  tctgctcta  gcgggaccg  gatgctcca  ccctaagcg  aaccaggat  5280
tcccacccc  aagcagtac  agatgctcc  ccctaagca  gatcagtat  ccccgcccc  5340
ccaagcgga  ccaggatgc  ccgccccca  gcaggacca  gatgccccg  ccccaagca  5400
gaccaggat  ccccgcccc  aagcgggac  aggatgccc  actcctaag  gggaccaga  5460
tccccaccc  aagcaggac  aggatgccc  gccctcctc  ggaacgtgg  tctaagaaa  5520
agagacctc  cctcacttc  ttagggacg  cgcctaccc  agcccggcc  ctgttaaag  5580
tctgcagct  tgcggctct  aggaggctg  tcccccagg  ggcgccgaa  acacccgct  5640
cgcaaccga  tcctgaggg  tcatttcct  agaaacctg  ctgcgcagg  agaaaggcg  5700
cagagcctc  tcctcgccg  aggctccgt  cctctcgtc  cccaccccc  cccccgtcc  5760
gagctccgg  gccccgagc  ctcgggtgg  agcgagagg  accctcagc  gtgaaaacg  5820
acaccgccc  ttccggggc  tcctcccct  acgctcctc  ctcctcttc  tcccgcgcc  5880
accccagaa  gtgcaggtg  agctgaccg  gctggacta  gacaagctg  gcaagaacg  5940
ggccatcgg  agggtggcc  tgggggcgg  cgccggcgg  gctggcctg  ggcactggg  6000
ggacatgct  gccaacccg  ggcggccca  tgcccagtg  cactcgctg  ggcccccgg  6060
ccgagtgag  ctgctgcct  cgccctgac  cccacccca  gcccccggc  aagcctgga  6120
tctagcccc  gaccccaga  tcccgagac  ggccaaagc  aagccagcc  cacccttaa  6180
cttcctctg  cggttaccc  ccccccacc  tccacccca  ccatctgaa  cattcctgt  6240
ttctcaccc  caacgatgc  aatcacgac  actttccag  acactcccc  gaccctcgc  6300
gacacaccc  gatgcccca  ggaccccgg  aagggaagg  agcctggtt  ctcctgccc  6360
cgggtcctg  cccctgctt  gacaatcag  catcctcgt  tgctctcct  tctcttcca  6420
cacagccca  ccctgcact  ctcctgagg  caaataaat  ttcagcagc  c  6471



<210> 8137
<211> 386
<212> PRT
<213> Homo sapiens
<308> O00445
<400> 8137

Met Phe Pro Glu Pro Pro Thr Pro Gly Pro Pro Ser Pro Asp Thr Pro 
  1               5                  10                  15
Pro Asp Ser Ser Arg Ile Ser His Gly Pro Val Pro Pro Trp Ala Leu 
             20                  25                  30
Ala Thr Ile Val Leu Val Ser Gly Leu Leu Ile Phe Ser Cys Cys Phe 
         35                  40                  45
Cys Leu Tyr Arg Lys Ser Cys Arg Arg Arg Thr Gly Lys Lys Ser Gln 
     50                  55                  60
Ala Gln Ala Gln Val His Leu Gln Glu Val Lys Gly Leu Gly Gln Ser 
 65                  70                  75                  80
Tyr Ile Asp Lys Val Gln Pro Glu Val Glu Glu Leu Glu Pro Ala Pro 
                 85                  90                  95
Ser Gly Pro Gly Gln Gln Val Xaa Asp Lys His Glu Leu Gly Arg Leu 
             100                105                110
Gln Tyr Ser Leu Asp Tyr Asp Phe Gln Ser Gly Gln Leu Leu Val Gly 
         115                120                125
Ile Leu Gln Ala Met Gly Leu Ala Ala Leu Asp Leu Gly Gly Ser Ser 
     130                135                140
Asp Pro Tyr Val Arg Val Tyr Leu Leu Xaa Asp Lys Arg Arg Arg Tyr 
 145                150                155                160
Glu Thr Lys Val His Arg Gln Thr Leu Asn Pro His Phe Gly Glu Thr 
                 165                170                175
Phe Ala Phe Lys Val Pro Tyr Val Glu Leu Gly Gly Arg Val Leu Val 
             180                185                190
Met Ala Val Tyr Asp Phe Asp Arg Phe Ser Arg Asn Asp Ala Ile Gly 
         195                200                205
Glu Val Arg Val Pro Met Ser Ser Val Asp Leu Gly Arg Pro Val Gln 
     210                215                220
Ala Trp Arg Glu Leu Gln Ala Ala Pro Arg Glu Glu Gln Glu Lys Leu 
 225                230                235                240
Gly Asp Ile Cys Phe Ser Leu Arg Tyr Val Pro Thr Ala Gly Lys Leu 
                 245                250                255
Thr Val Ile Val Leu Glu Ala Lys Asn Leu Lys Lys Met Asp Val Gly 
             260                265                270
Gly Leu Ser Asp Pro Tyr Val Lys Val His Leu Leu Gln Gly Gly Lys 
         275                280                285
Lys Val Arg Lys Lys Lys Thr Thr Ile Lys Lys Asn Thr Leu Asn Pro 
     290                295                300
Tyr Tyr Asn Glu Ala Phe Ser Phe Glu Val Pro Cys Asp Gln Val Gln 
 305                310                315                320
Lys Val Gln Val Glu Leu Thr Val Leu Asp Tyr Asp Lys Leu Gly Lys 
                 325                330                335
Asn Glu Ala Ile Gly Arg Val Ala Val Gly Ala Ala Ala Gly Gly Ala 
             340                345                350
Gly Leu Arg His Trp Ala Asp Met Leu Ala Asn Pro Arg Arg Pro Ile 
         355                360                365
Ala Gln Trp His Ser Leu Arg Pro Pro Asp Arg Val Arg Leu Leu Pro 
     370                375                380
Ala Pro 
 385



<210> 8138
<211> 2060
<212> DNA
<213> Rattus norvegicus
<308> U14398
<400> 8138

gctgcagga  ttccctctt  ctttcaatc  gtgaaattg  ccttccggt  aagaggctg  60
aatctccca  taagacgag  agacccaac  ggaacaggg  agggtggca  attgctgat  120
gagagcgcg  accttcctc  agcccctcc  gctgccgct  ccggtcccc  gatcccccg  180
gtttcccct  gaagccttg  ttcagggtc  ttccaggtg  atctgcctg  agttctttc  240
gcacctcgg  cagagcacg  agaaaacat  gctcctatc  ccaccagcc  cgtggaatt  300
gatgaaatt  ccacagtgg  gggcatctt  agtgctttt  gcctggtct  cactgtgtc  360
ctctttgcc  ggatctgct  ccagagaag  tccgctaag  ccaacaaga  tcctccata  420
aagtttgtg  acgtgctta  aggagttga  atctaccca  aaaacctaa  tagcaaaaa  480
aagtttgga  gagatgaca  gagtgaagc  aagcgtaaa  cagctttgc  taacctttc  540
ctgcacctt  atctcgaga  gcgagacct  aatggcaat  tccccaaaa  caaccccaa  600
gctggcagc  cttctgatc  ggaaaatgt  accccaaag  tctttccgg  gacggaaaa  660
gaggccgtc  cccctgaga  cttgaagtc  agcacttcc  tcacttcag  ggagaaaca  720
gagaagctg  gcactctct  cttgtctct  gagtacaac  tcgagaaga  agcatttgt  780
gtgaacatc  aggaagccc  gggcttacc  gccatggat  aacaatcca  gacctctga  840
ccatacatc  agatgacaa  cttaccaga  aagaagcac  aagtgaaaa  cagagtgct  900
aggaagacg  tggaccccg  gtttgacga  accttcaca  tctatgggg  cccttatcc  960
cacatccaa  agctgtccc  gcacttcac  gtcctgagt  ttgacaggt  ctcaagaga  1020
gatgtcatt  gagaagtcc  cgttcctct  tcagggatt  aattgtcag  cgggaaaat  1080
ttaatgacc  gagagatca  caagagaaa  gctaagaag  cttctggac  gggtgaact  1140
ctggtctcc  tctgttatc  gtccactac  aacacgctc  ctgtggttg  cttaaaagc  1200
cggcaccta  cgaaatctg  tgtgtctgg  ctttcagat  cctacgtca  agtgaacct  1260
taccatgcc  agaagagaa  ctctaaaaa  aagactcac  tgaaaaagt  cactcccaa  1320
gcagtgttc  acgaactgt  tgtctttga  attccttgt  agagtcttg  agaaataag  1380
gttgaattt  tagttttgg  ttctgaaag  ggatcccga  atgaggtga  cgggcggtt  1440
gtcctgggt  ccacagcag  aggaagtgg  ggggggcac  ggaaggaga  ctgtgactt  1500
cccaggaga  aaattgcta  gtggcatat  ctctgtgat  gttagcttc  tggccacca  1560
ctacaactt  aaggttttt  ctaggcgag  agcaatttt  tttcttata  gcgattgta  1620
gcttgtggc  cagcaagct  ctttactat  tatttgttt  ggttagaag  ggattaaat  1680
agtagacca  aagatagct  taaatgtgt  ttatgataa  ttcctcttt  attagaggc  1740
ttggccaag  tttcataag  tactgtttc  ctctgtgtg  attaagtgg  ccaaccaag  1800
ctgttatga  cattctagc  taacctcaa  tcacagatg  gtgttgtgg  tgatttcat  1860
ttttgcctt  gtagtggaa  tcaggtgat  gttaagagt  aaaagtggg  aaaaaaaca  1920
acctaagct  gaatttcag  taggaatac  gttgttttt  atataaaaa  ctatcagtg  1980
acaagtgta  tttcaagat  gtctttccc  ctcacagtg  acatggcca  ctaagtttt  2040
taacttact  tttcccaggc  2060



<210> 8139
<211> 425
<212> PRT
<213> Rattus norvegicus
<308> P50232
<400> 8139

Met Ala Pro Ile Thr Thr Ser Arg Val Glu Phe Asp Glu Ile Pro Thr 
  1               5                  10                  15
Val Val Gly Ile Phe Ser Ala Phe Gly Leu Val Phe Thr Val Ser Leu 
             20                  25                  30
Phe Ala Trp Ile Cys Cys Gln Arg Arg Ser Ala Lys Ser Asn Lys Thr 
         35                  40                  45
Pro Pro Tyr Lys Phe Val His Val Leu Lys Gly Val Asp Ile Tyr Pro 
     50                  55                  60
Glu Asn Leu Ser Ser Lys Lys Lys Phe Gly Gly Asp Asp Lys Ser Glu 
 65                  70                  75                  80
Ala Lys Arg Lys Ala Ala Leu Pro Asn Leu Ser Leu His Leu Asp Leu 
                 85                  90                  95
Glu Lys Arg Asp Leu Asn Gly Asn Phe Pro Lys Thr Asn Pro Lys Ala 
             100                105                110
Gly Ser Ser Ser Asp Leu Glu Asn Val Thr Pro Lys Leu Phe Pro Glu 
         115                120                125
Thr Glu Lys Glu Ala Val Ser Pro Glu Ser Leu Lys Ser Ser Thr Ser 
     130                135                140
Leu Thr Ser Glu Glu Lys Gln Glu Lys Leu Gly Thr Leu Phe Leu Ser 
 145                150                155                160
Leu Glu Tyr Asn Phe Glu Lys Lys Ala Phe Val Val Asn Ile Lys Glu 
                 165                170                175
Ala Gln Gly Leu Pro Ala Met Asp Glu Gln Ser Met Thr Ser Asp Pro 
             180                185                190
Tyr Ile Lys Met Thr Ile Leu Pro Glu Lys Lys His Lys Val Lys Thr 
         195                200                205
Arg Val Leu Arg Lys Thr Leu Asp Pro Val Phe Asp Glu Thr Phe Thr 
     210                215                220
Phe Tyr Gly Val Pro Tyr Pro His Ile Gln Glu Leu Ser Leu His Phe 
 225                230                235                240
Thr Val Leu Ser Phe Asp Arg Phe Ser Arg Asp Asp Val Ile Gly Glu 
                 245                250                255
Val Leu Val Pro Leu Ser Gly Ile Glu Leu Ser Asp Gly Lys Met Leu 
             260                265                270
Met Thr Arg Glu Ile Ile Lys Arg Asn Ala Lys Lys Ser Ser Gly Arg 
         275                280                285
Gly Glu Leu Leu Val Ser Leu Cys Tyr Gln Ser Thr Thr Asn Thr Leu 
     290                295                300
Thr Val Val Val Leu Lys Ala Arg His Leu Pro Lys Ser Asp Val Ser 
 305                310                315                320
Gly Leu Ser Asp Pro Tyr Val Lys Val Asn Leu Tyr His Ala Lys Lys 
                 325                330                335
Arg Ile Ser Lys Lys Lys Thr His Val Lys Lys Cys Thr Pro Asn Ala 
             340                345                350
Val Phe Asn Glu Leu Phe Val Phe Asp Ile Pro Cys Glu Ser Leu Glu 
         355                360                365
Glu Ile Ser Val Glu Phe Leu Val Leu Asp Ser Glu Arg Gly Ser Arg 
     370                375                380
Asn Glu Val Ile Gly Arg Leu Val Leu Gly Ala Thr Ala Glu Gly Ser 
 385                390                395                400
Gly Gly Gly His Trp Lys Glu Ile Cys Asp Phe Pro Arg Arg Gln Ile 
                 405                410                415
Ala Lys Trp His Met Leu Cys Asp Gly 
             420                425



<210> 8140
<211> 6471
<212> DNA
<213> Homo sapiens
<308> X96783
<400> 8140

ggcccaggc  ccggtgggc  ccggagcga  cctgccccg  cgggactcc  cgtctgtgc  60
tcagccccg  ccgttgtcc  ggcaacaac  cgttgcccg  gcaaccagc  ttgctctta  120
cccgcttga  aggagcccg  ctgttgctc  gggcaacgc  gtctgctgg  tcccacgtc  180
gccttcgcc  gcttccggt  cagaccctg  ggaggggcg  ggacgaggc  gaagtcagc  240
ggatgcctg  ggggccgtg  aggaagagg  tatcccttt  ggatggaac  aggtcctgg  300
caccccctc  caagtgcgg  gaggctgat  ctacaactc  cagcatgac  cgcggtggc  360
gtccggttt  tgcgcggct  ttcgcgcaa  ggcctcatg  gagttggag  tctttgttg  420
gcgtggggc  caaaggacg  ctggggtgg  aatggggga  tagggtgct  gagtgtctc  480
gcagaaaag  ctccaggac  ccgccacca  gttcccgga  cccccaacc  cggggcctc  540
atcgcccga  acgcctccc  actccagtc  catcagcca  ggcccaggt  agcaagacc  600
gggggtggg  ggccgagca  agagaaagc  tggccagga  tccgagggg  gggattcgg  660
cgggtgtac  cgggcaggc  ggctggaaa  tccggctgg  atcccgggt  gtcatcctg  720
actggaatg  gaacgaaat  gggtaaaag  aaggaacag  tttgcaaaa  aaaaaaaaa  780
aaaaaaaaa  aaaatcgaa  ccggatcaa  gggtgttgc  tggaatggg  tcttagaat  840
ggaaggtcc  cctagctct  cttttacag  taaggaaac  ggcccgatg  ggagcaggg  900
ttcttgtaa  agcatcagg  gttgagcag  aatgggggg  ggggtcggg  aaggaaagg  960
agaactaac  agcaagcaa  yccagatgg  gtcagcctg  gttggggca  cgaatctct  1020
tataggcca  attaggtgg  agaaaaaca  aggaagaaa  gcaatgaaa  tggctggag  1080
gaaaaggag  ccagcattc  agcttccac  tgtaatcag  actgaatca  cctgcgtgc  1140
gcccaggcc  caatgtgtg  tgtctccac  cctctgcag  gcccccctg  gccctggcc  1200
ccatcgtrc  ggtctcagg  ctcctcatc  tcagctgct  tttctgtct  taccggaag  1260
gctgtcgga  gcggacagg  aagaagagc  aggcccaag  ccaggtcca  cttcaggaa  1320
tgaaggggc  gggccagag  tacatagac  aggtgtggc  cagcccagc  cctccacct  1380
gccccttcc  gcaccctgc  cctctcaat  gcccagctg  tcccagtcc  tgctccctt  1440
tgtcctata  gaacccacc  tactggctc  tcctccctg  gtgtctagc  ctcaactgg  1500
ctctgggga  ccagagatg  aacagaact  gttgctatt  ccaagaact  cccagtctg  1560
tgggagagt  aggcactga  acagacact  accacacag  gtaatatgt  ccatactac  1620
gggtctcat  ggagcacag  aaaggcatc  cactgtata  aaacctaca  aaacatata  1680
atatttggc  ctgggccgg  tgcggtggc  cacgcctgt  atcctagca  ttgggaggc  1740
gaggtggac  gattgcctg  ggtcatgaa  tcaagacta  cctgggcaa  atgatgaaa  1800
cctgtctct  ctaaaaata  aaaagccar  catggtggt  tggtataat  ccagctact  1860
gagaggctg  ggcactgaa  ccgggaggt  gaggctgca  tgagctgtg  tcgcgccac  1920
gcactccag  ctgggtgac  gagcgagac  ctgtctcca  taaatagat  aataaataa  1980
tggctctga  agctgaaaa  cagctttgt  ccagaatac  ttaaaatat  ctgattttt  2040
tcagaaaat  ggacatatt  acagtagga  aargtttaa  acagagggt  agacagagg  2100
ggcttcgtg  tggaggtga  ttctgcact  agacctgag  gacagagtt  actgagacc  2160
gagagaagg  cattctagt  caagttgga  catgtgtwg  ggccccata  ccagattca  2220
gccccatat  cagattcyg  ggcttattt  gggaacaaa  agtcatttc  cacaatagc  2280
gcactctgg  gtgaagtgt  tggagaact  agcagtatc  atgtcatga  ggtgatgaa  2340
gctacaaat  tgttttgag  atgagaggg  cagggtcag  tggtgttag  atgactcct  2400
tggaaccct  tgtaggaca  atctgcggc  agggatcca  ggacgaggc  agtgcagca  2460
cagcctgga  aggataaaa  acatttgca  tggatgagg  cgttggaat  gaaagtggt  2520
actgcaggg  ctgaaaatt  agtctctca  tgcagagtg  agtggttgc  tgggagcca  2580
acagcccta  gtttccaac  aagaaggac  atttcctgg  tgtgtgacc  tggagaact  2640
actgtccct  tctgagcct  aagtctgtg  tcactaact  ggtatttcc  ctccttcct  2700
ctcaataag  agctgttca  ttagcatcc  taaaggatg  tatttaggg  cctggtgtc  2760
agccccatc  ctgtccctt  aaccagtga  gttcaaaga  cgtctgcag  agaatcaca  2820
tgggtactt  ttgaaatgc  aattctggc  ctagcacct  acctatcaa  tcagaatcc  2880
tgaagaggt  acctcagac  ttttgccac  ggattcagg  gaattcagg  tcacattga  2940
ttttaagaa  tgctggcct  ggttaagga  acaccttct  ctttttcat  caactttag  3000
atggcaagt  cacagtaaa  atgccattt  tcctccatg  tttgctgtg  taagatcac  3060
agtaaacat  gcagtttgg  ctagcaccc  agtacatcc  ttagcatgt  aaataaaac  3120
tgcattatt  ctgtgggca  tgggacact  tcagcactt  ttttaatct  agcatgaca  3180
gcacatgtc  agttcctgc  catagcaga  accactaat  aaaccttca  aaacatact  3240
catctgtgt  accacgtct  tttcctgcc  gtggcagac  gcactagtc  aatactgaa  3300
ctgcttagc  tgtgagagc  caggtatag  ccaagggac  tgtgagcct  ccttggctt  3360
tgagcctga  ggatactgc  atcagggga  gacttcacc  acccttacc  ctggctcct  3420
aaggtgcag  cagaagtag  ggagctgga  ccagcacca  ccgggccag  gcagcaggt  3480
scagacaag  atgagctag  acgactgca  tactccctg  attatgact  ccagagtgg  3540
caggtgggt  tggaggaag  ggaagcttt  gagggagga  cccgggggt  ccaacccct  3600
ctgaaagga  ccatggaag  gaggctaag  ctagtgttc  ccacctccc  cactgtgcc  3660
gggccctgc  gctgctggt  ggcattctg  aagcaatgg  attggcagc  ttggatctt  3720
gtggctcct  ggaccccta  gtgcgggtc  acctgctgm  ggacaaacg  aggcggtac  3780
agaccaagg  gcatcggca  acgctgaac  ctcactttg  ggagacctt  gccttcaag  3840
tgagctctg  ttcaggccc  gtgttccat  gcctgtgcc  agtccctgg  acactaggg  3900
ccgacccct  ccgcttttc  tggaggcag  cacagctca  gtggcagct  ccagctctg  3960
ggctattcc  ctggaccct  ggcactact  actcctggg  tgtagcctg  tccttgggc  4020
gtacgattt  ggttccact  acccgtgat  tttttccgc  tggatccct  gactttccc  4080
tttgagttc  cccaactgt  cgcttcgac  ctcgctgcc  cactccacg  cttccttct  4140
gttgtgctg  gcctcaccc  atctctgac  tcctgctct  tactgcgga  tctctgtgc  4200
ctccaggtm  cctacgtgg  gctgggggg  agggtgctg  tcatggcgg  gtacgactt  4260
gaccgcttc  ctcgcaatg  cgccatcgg  gaggtgcgg  tccctatga  ctccgtgga  4320
ctggggcgg  cagtgcagg  ctggcggga  ctgcaggcg  ctccgcggg  ggaggtgag  4380
atgcgcggt  gcgccccga  ccacgcccc  aggcccagt  ccgcccaca  catcctgag  4440
caatcagat  ataggcttt  cagaccctc  gggcggcgt  gattgtacc  ctgaggagg  4500
atggatgtg  agccggggc  ctggtgatg  gcccctctc  tttcagcag  agaagcttg  4560
ggacatctg  ttctccctc  gctatgtcc  cacggccgg  aagctcacc  tcatcgtcc  4620
ggaggctaa  aacctgaag  agatggacg  aggaggact  tcaggtgtg  gggaagcaa  4680
ggagtgggg  gtgagggga  ggcgtgggg  gggttctcg  tctgacagt  tctgagcct  4740
gagggtttc  tcggggaca  ggaggacct  gctgctgtg  aaggcatgg  ttttggcat  4800
gagctaggg  gacccgaag  gtgtaggca  tgtttctat  ttggtccaa  aacccagca  4860
tggggagct  taagactcc  ccttcctct  cccagatcc  tacgtcaag  tccacctgc  4920
gcagggcgg  aaaaaggtg  ggaagaaga  aaccaccat  aagaagaac  ctctgaacc  4980
ctattacaa  gaagctttc  gcttcgagg  gccctgtga  caagtccag  tgagctcaa  5040
cctgccctt  tccaagagc  cagaccttt  gtaatcgcc  ttgctaggc  gagggagac  5100
ttttagcat  tccctagaa  ccaggtgag  gggtctgag  ttatgctct  agtctgttt  5160
ctcctatga  gaccaggaa  cctcttcca  tccaggaag  gactcctta  aattgggtg  5220
gggtgtcct  tctgctcta  gcgggaccg  gatgctcca  ccctaagcg  aaccaggat  5280
tcccacccc  aagcagtac  agatgctcc  ccctaagca  gatcagtat  ccccgcccc  5340
ccaagcgga  ccaggatgc  ccgccccca  gcaggacca  gatgccccg  ccccaagca  5400
gaccaggat  ccccgcccc  aagcgggac  aggatgccc  actcctaag  gggaccaga  5460
tccccaccc  aagcaggac  aggatgccc  gccctcctc  ggaacgtgg  tctaagaaa  5520
agagacctc  cctcacttc  ttagggacg  cgcctaccc  agcccggcc  ctgttaaag  5580
tctgcagct  tgcggctct  aggaggctg  tcccccagg  ggcgccgaa  acacccgct  5640
cgcaaccga  tcctgaggg  tcatttcct  agaaacctg  ctgcgcagg  agaaaggcg  5700
cagagcctc  tcctcgccg  aggctccgt  cctctcgtc  cccaccccc  cccccgtcc  5760
gagctccgg  gccccgagc  ctcgggtgg  agcgagagg  accctcagc  gtgaaaacg  5820
acaccgccc  ttccggggc  tcctcccct  acgctcctc  ctcctcttc  tcccgcgcc  5880
accccagaa  gtgcaggtg  agctgaccg  gctggacta  gacaagctg  gcaagaacg  5940
ggccatcgg  agggtggcc  tgggggcgg  cgccggcgg  gctggcctg  ggcactggg  6000
ggacatgct  gccaacccg  ggcggccca  tgcccagtg  cactcgctg  ggcccccgg  6060
ccgagtgag  ctgctgcct  cgccctgac  cccacccca  gcccccggc  aagcctgga  6120
tctagcccc  gaccccaga  tcccgagac  ggccaaagc  aagccagcc  cacccttaa  6180
cttcctctg  cggttaccc  ccccccacc  tccacccca  ccatctgaa  cattcctgt  6240
ttctcaccc  caacgatgc  aatcacgac  actttccag  acactcccc  gaccctcgc  6300
gacacaccc  gatgcccca  ggaccccgg  aagggaagg  agcctggtt  ctcctgccc  6360
cgggtcctg  cccctgctt  gacaatcag  catcctcgt  tgctctcct  tctcttcca  6420
cacagccca  ccctgcact  ctcctgagg  caaataaat  ttcagcagc  c  6471



<210> 8141
<211> 386
<212> PRT
<213> Homo sapiens
<308> O00445
<400> 8141

Met Phe Pro Glu Pro Pro Thr Pro Gly Pro Pro Ser Pro Asp Thr Pro 
  1               5                  10                  15
Pro Asp Ser Ser Arg Ile Ser His Gly Pro Val Pro Pro Trp Ala Leu 
             20                  25                  30
Ala Thr Ile Val Leu Val Ser Gly Leu Leu Ile Phe Ser Cys Cys Phe 
         35                  40                  45
Cys Leu Tyr Arg Lys Ser Cys Arg Arg Arg Thr Gly Lys Lys Ser Gln 
     50                  55                  60
Ala Gln Ala Gln Val His Leu Gln Glu Val Lys Gly Leu Gly Gln Ser 
 65                  70                  75                  80
Tyr Ile Asp Lys Val Gln Pro Glu Val Glu Glu Leu Glu Pro Ala Pro 
                 85                  90                  95
Ser Gly Pro Gly Gln Gln Val Xaa Asp Lys His Glu Leu Gly Arg Leu 
             100                105                110
Gln Tyr Ser Leu Asp Tyr Asp Phe Gln Ser Gly Gln Leu Leu Val Gly 
         115                120                125
Ile Leu Gln Ala Met Gly Leu Ala Ala Leu Asp Leu Gly Gly Ser Ser 
     130                135                140
Asp Pro Tyr Val Arg Val Tyr Leu Leu Xaa Asp Lys Arg Arg Arg Tyr 
 145                150                155                160
Glu Thr Lys Val His Arg Gln Thr Leu Asn Pro His Phe Gly Glu Thr 
                 165                170                175
Phe Ala Phe Lys Val Pro Tyr Val Glu Leu Gly Gly Arg Val Leu Val 
             180                185                190
Met Ala Val Tyr Asp Phe Asp Arg Phe Ser Arg Asn Asp Ala Ile Gly 
         195                200                205
Glu Val Arg Val Pro Met Ser Ser Val Asp Leu Gly Arg Pro Val Gln 
     210                215                220
Ala Trp Arg Glu Leu Gln Ala Ala Pro Arg Glu Glu Gln Glu Lys Leu 
 225                230                235                240
Gly Asp Ile Cys Phe Ser Leu Arg Tyr Val Pro Thr Ala Gly Lys Leu 
                 245                250                255
Thr Val Ile Val Leu Glu Ala Lys Asn Leu Lys Lys Met Asp Val Gly 
             260                265                270
Gly Leu Ser Asp Pro Tyr Val Lys Val His Leu Leu Gln Gly Gly Lys 
         275                280                285
Lys Val Arg Lys Lys Lys Thr Thr Ile Lys Lys Asn Thr Leu Asn Pro 
     290                295                300
Tyr Tyr Asn Glu Ala Phe Ser Phe Glu Val Pro Cys Asp Gln Val Gln 
 305                310                315                320
Lys Val Gln Val Glu Leu Thr Val Leu Asp Tyr Asp Lys Leu Gly Lys 
                 325                330                335
Asn Glu Ala Ile Gly Arg Val Ala Val Gly Ala Ala Ala Gly Gly Ala 
             340                345                350
Gly Leu Arg His Trp Ala Asp Met Leu Ala Asn Pro Arg Arg Pro Ile 
         355                360                365
Ala Gln Trp His Ser Leu Arg Pro Pro Asp Arg Val Arg Leu Leu Pro 
     370                375                380
Ala Pro 
 385



<210> 8142
<211> 2060
<212> DNA
<213> Rattus norvegicus
<308> U14398
<400> 8142

gctgcagga  ttccctctt  ctttcaatc  gtgaaattg  ccttccggt  aagaggctg  60
aatctccca  taagacgag  agacccaac  ggaacaggg  agggtggca  attgctgat  120
gagagcgcg  accttcctc  agcccctcc  gctgccgct  ccggtcccc  gatcccccg  180
gtttcccct  gaagccttg  ttcagggtc  ttccaggtg  atctgcctg  agttctttc  240
gcacctcgg  cagagcacg  agaaaacat  gctcctatc  ccaccagcc  cgtggaatt  300
gatgaaatt  ccacagtgg  gggcatctt  agtgctttt  gcctggtct  cactgtgtc  360
ctctttgcc  ggatctgct  ccagagaag  tccgctaag  ccaacaaga  tcctccata  420
aagtttgtg  acgtgctta  aggagttga  atctaccca  aaaacctaa  tagcaaaaa  480
aagtttgga  gagatgaca  gagtgaagc  aagcgtaaa  cagctttgc  taacctttc  540
ctgcacctt  atctcgaga  gcgagacct  aatggcaat  tccccaaaa  caaccccaa  600
gctggcagc  cttctgatc  ggaaaatgt  accccaaag  tctttccgg  gacggaaaa  660
gaggccgtc  cccctgaga  cttgaagtc  agcacttcc  tcacttcag  ggagaaaca  720
gagaagctg  gcactctct  cttgtctct  gagtacaac  tcgagaaga  agcatttgt  780
gtgaacatc  aggaagccc  gggcttacc  gccatggat  aacaatcca  gacctctga  840
ccatacatc  agatgacaa  cttaccaga  aagaagcac  aagtgaaaa  cagagtgct  900
aggaagacg  tggaccccg  gtttgacga  accttcaca  tctatgggg  cccttatcc  960
cacatccaa  agctgtccc  gcacttcac  gtcctgagt  ttgacaggt  ctcaagaga  1020
gatgtcatt  gagaagtcc  cgttcctct  tcagggatt  aattgtcag  cgggaaaat  1080
ttaatgacc  gagagatca  caagagaaa  gctaagaag  cttctggac  gggtgaact  1140
ctggtctcc  tctgttatc  gtccactac  aacacgctc  ctgtggttg  cttaaaagc  1200
cggcaccta  cgaaatctg  tgtgtctgg  ctttcagat  cctacgtca  agtgaacct  1260
taccatgcc  agaagagaa  ctctaaaaa  aagactcac  tgaaaaagt  cactcccaa  1320
gcagtgttc  acgaactgt  tgtctttga  attccttgt  agagtcttg  agaaataag  1380
gttgaattt  tagttttgg  ttctgaaag  ggatcccga  atgaggtga  cgggcggtt  1440
gtcctgggt  ccacagcag  aggaagtgg  ggggggcac  ggaaggaga  ctgtgactt  1500
cccaggaga  aaattgcta  gtggcatat  ctctgtgat  gttagcttc  tggccacca  1560
ctacaactt  aaggttttt  ctaggcgag  agcaatttt  tttcttata  gcgattgta  1620
gcttgtggc  cagcaagct  ctttactat  tatttgttt  ggttagaag  ggattaaat  1680
agtagacca  aagatagct  taaatgtgt  ttatgataa  ttcctcttt  attagaggc  1740
ttggccaag  tttcataag  tactgtttc  ctctgtgtg  attaagtgg  ccaaccaag  1800
ctgttatga  cattctagc  taacctcaa  tcacagatg  gtgttgtgg  tgatttcat  1860
ttttgcctt  gtagtggaa  tcaggtgat  gttaagagt  aaaagtggg  aaaaaaaca  1920
acctaagct  gaatttcag  taggaatac  gttgttttt  atataaaaa  ctatcagtg  1980
acaagtgta  tttcaagat  gtctttccc  ctcacagtg  acatggcca  ctaagtttt  2040
taacttact  tttcccaggc  2060



<210> 8143
<211> 425
<212> PRT
<213> Rattus norvegicus
<308> P50232
<400> 8143

Met Ala Pro Ile Thr Thr Ser Arg Val Glu Phe Asp Glu Ile Pro Thr 
  1               5                  10                  15
Val Val Gly Ile Phe Ser Ala Phe Gly Leu Val Phe Thr Val Ser Leu 
             20                  25                  30
Phe Ala Trp Ile Cys Cys Gln Arg Arg Ser Ala Lys Ser Asn Lys Thr 
         35                  40                  45
Pro Pro Tyr Lys Phe Val His Val Leu Lys Gly Val Asp Ile Tyr Pro 
     50                  55                  60
Glu Asn Leu Ser Ser Lys Lys Lys Phe Gly Gly Asp Asp Lys Ser Glu 
 65                  70                  75                  80
Ala Lys Arg Lys Ala Ala Leu Pro Asn Leu Ser Leu His Leu Asp Leu 
                 85                  90                  95
Glu Lys Arg Asp Leu Asn Gly Asn Phe Pro Lys Thr Asn Pro Lys Ala 
             100                105                110
Gly Ser Ser Ser Asp Leu Glu Asn Val Thr Pro Lys Leu Phe Pro Glu 
         115                120                125
Thr Glu Lys Glu Ala Val Ser Pro Glu Ser Leu Lys Ser Ser Thr Ser 
     130                135                140
Leu Thr Ser Glu Glu Lys Gln Glu Lys Leu Gly Thr Leu Phe Leu Ser 
 145                150                155                160
Leu Glu Tyr Asn Phe Glu Lys Lys Ala Phe Val Val Asn Ile Lys Glu 
                 165                170                175
Ala Gln Gly Leu Pro Ala Met Asp Glu Gln Ser Met Thr Ser Asp Pro 
             180                185                190
Tyr Ile Lys Met Thr Ile Leu Pro Glu Lys Lys His Lys Val Lys Thr 
         195                200                205
Arg Val Leu Arg Lys Thr Leu Asp Pro Val Phe Asp Glu Thr Phe Thr 
     210                215                220
Phe Tyr Gly Val Pro Tyr Pro His Ile Gln Glu Leu Ser Leu His Phe 
 225                230                235                240
Thr Val Leu Ser Phe Asp Arg Phe Ser Arg Asp Asp Val Ile Gly Glu 
                 245                250                255
Val Leu Val Pro Leu Ser Gly Ile Glu Leu Ser Asp Gly Lys Met Leu 
             260                265                270
Met Thr Arg Glu Ile Ile Lys Arg Asn Ala Lys Lys Ser Ser Gly Arg 
         275                280                285
Gly Glu Leu Leu Val Ser Leu Cys Tyr Gln Ser Thr Thr Asn Thr Leu 
     290                295                300
Thr Val Val Val Leu Lys Ala Arg His Leu Pro Lys Ser Asp Val Ser 
 305                310                315                320
Gly Leu Ser Asp Pro Tyr Val Lys Val Asn Leu Tyr His Ala Lys Lys 
                 325                330                335
Arg Ile Ser Lys Lys Lys Thr His Val Lys Lys Cys Thr Pro Asn Ala 
             340                345                350
Val Phe Asn Glu Leu Phe Val Phe Asp Ile Pro Cys Glu Ser Leu Glu 
         355                360                365
Glu Ile Ser Val Glu Phe Leu Val Leu Asp Ser Glu Arg Gly Ser Arg 
     370                375                380
Asn Glu Val Ile Gly Arg Leu Val Leu Gly Ala Thr Ala Glu Gly Ser 
 385                390                395                400
Gly Gly Gly His Trp Lys Glu Ile Cys Asp Phe Pro Arg Arg Gln Ile 
                 405                410                415
Ala Lys Trp His Met Leu Cys Asp Gly 
             420                425



<210> 8144
<211> 6471
<212> DNA
<213> Homo sapiens
<308> X96783
<400> 8144

ggcccaggc  ccggtgggc  ccggagcga  cctgccccg  cgggactcc  cgtctgtgc  60
tcagccccg  ccgttgtcc  ggcaacaac  cgttgcccg  gcaaccagc  ttgctctta  120
cccgcttga  aggagcccg  ctgttgctc  gggcaacgc  gtctgctgg  tcccacgtc  180
gccttcgcc  gcttccggt  cagaccctg  ggaggggcg  ggacgaggc  gaagtcagc  240
ggatgcctg  ggggccgtg  aggaagagg  tatcccttt  ggatggaac  aggtcctgg  300
caccccctc  caagtgcgg  gaggctgat  ctacaactc  cagcatgac  cgcggtggc  360
gtccggttt  tgcgcggct  ttcgcgcaa  ggcctcatg  gagttggag  tctttgttg  420
gcgtggggc  caaaggacg  ctggggtgg  aatggggga  tagggtgct  gagtgtctc  480
gcagaaaag  ctccaggac  ccgccacca  gttcccgga  cccccaacc  cggggcctc  540
atcgcccga  acgcctccc  actccagtc  catcagcca  ggcccaggt  agcaagacc  600
gggggtggg  ggccgagca  agagaaagc  tggccagga  tccgagggg  gggattcgg  660
cgggtgtac  cgggcaggc  ggctggaaa  tccggctgg  atcccgggt  gtcatcctg  720
actggaatg  gaacgaaat  gggtaaaag  aaggaacag  tttgcaaaa  aaaaaaaaa  780
aaaaaaaaa  aaaatcgaa  ccggatcaa  gggtgttgc  tggaatggg  tcttagaat  840
ggaaggtcc  cctagctct  cttttacag  taaggaaac  ggcccgatg  ggagcaggg  900
ttcttgtaa  agcatcagg  gttgagcag  aatgggggg  ggggtcggg  aaggaaagg  960
agaactaac  agcaagcaa  yccagatgg  gtcagcctg  gttggggca  cgaatctct  1020
tataggcca  attaggtgg  agaaaaaca  aggaagaaa  gcaatgaaa  tggctggag  1080
gaaaaggag  ccagcattc  agcttccac  tgtaatcag  actgaatca  cctgcgtgc  1140
gcccaggcc  caatgtgtg  tgtctccac  cctctgcag  gcccccctg  gccctggcc  1200
ccatcgtrc  ggtctcagg  ctcctcatc  tcagctgct  tttctgtct  taccggaag  1260
gctgtcgga  gcggacagg  aagaagagc  aggcccaag  ccaggtcca  cttcaggaa  1320
tgaaggggc  gggccagag  tacatagac  aggtgtggc  cagcccagc  cctccacct  1380
gccccttcc  gcaccctgc  cctctcaat  gcccagctg  tcccagtcc  tgctccctt  1440
tgtcctata  gaacccacc  tactggctc  tcctccctg  gtgtctagc  ctcaactgg  1500
ctctgggga  ccagagatg  aacagaact  gttgctatt  ccaagaact  cccagtctg  1560
tgggagagt  aggcactga  acagacact  accacacag  gtaatatgt  ccatactac  1620
gggtctcat  ggagcacag  aaaggcatc  cactgtata  aaacctaca  aaacatata  1680
atatttggc  ctgggccgg  tgcggtggc  cacgcctgt  atcctagca  ttgggaggc  1740
gaggtggac  gattgcctg  ggtcatgaa  tcaagacta  cctgggcaa  atgatgaaa  1800
cctgtctct  ctaaaaata  aaaagccar  catggtggt  tggtataat  ccagctact  1860
gagaggctg  ggcactgaa  ccgggaggt  gaggctgca  tgagctgtg  tcgcgccac  1920
gcactccag  ctgggtgac  gagcgagac  ctgtctcca  taaatagat  aataaataa  1980
tggctctga  agctgaaaa  cagctttgt  ccagaatac  ttaaaatat  ctgattttt  2040
tcagaaaat  ggacatatt  acagtagga  aargtttaa  acagagggt  agacagagg  2100
ggcttcgtg  tggaggtga  ttctgcact  agacctgag  gacagagtt  actgagacc  2160
gagagaagg  cattctagt  caagttgga  catgtgtwg  ggccccata  ccagattca  2220
gccccatat  cagattcyg  ggcttattt  gggaacaaa  agtcatttc  cacaatagc  2280
gcactctgg  gtgaagtgt  tggagaact  agcagtatc  atgtcatga  ggtgatgaa  2340
gctacaaat  tgttttgag  atgagaggg  cagggtcag  tggtgttag  atgactcct  2400
tggaaccct  tgtaggaca  atctgcggc  agggatcca  ggacgaggc  agtgcagca  2460
cagcctgga  aggataaaa  acatttgca  tggatgagg  cgttggaat  gaaagtggt  2520
actgcaggg  ctgaaaatt  agtctctca  tgcagagtg  agtggttgc  tgggagcca  2580
acagcccta  gtttccaac  aagaaggac  atttcctgg  tgtgtgacc  tggagaact  2640
actgtccct  tctgagcct  aagtctgtg  tcactaact  ggtatttcc  ctccttcct  2700
ctcaataag  agctgttca  ttagcatcc  taaaggatg  tatttaggg  cctggtgtc  2760
agccccatc  ctgtccctt  aaccagtga  gttcaaaga  cgtctgcag  agaatcaca  2820
tgggtactt  ttgaaatgc  aattctggc  ctagcacct  acctatcaa  tcagaatcc  2880
tgaagaggt  acctcagac  ttttgccac  ggattcagg  gaattcagg  tcacattga  2940
ttttaagaa  tgctggcct  ggttaagga  acaccttct  ctttttcat  caactttag  3000
atggcaagt  cacagtaaa  atgccattt  tcctccatg  tttgctgtg  taagatcac  3060
agtaaacat  gcagtttgg  ctagcaccc  agtacatcc  ttagcatgt  aaataaaac  3120
tgcattatt  ctgtgggca  tgggacact  tcagcactt  ttttaatct  agcatgaca  3180
gcacatgtc  agttcctgc  catagcaga  accactaat  aaaccttca  aaacatact  3240
catctgtgt  accacgtct  tttcctgcc  gtggcagac  gcactagtc  aatactgaa  3300
ctgcttagc  tgtgagagc  caggtatag  ccaagggac  tgtgagcct  ccttggctt  3360
tgagcctga  ggatactgc  atcagggga  gacttcacc  acccttacc  ctggctcct  3420
aaggtgcag  cagaagtag  ggagctgga  ccagcacca  ccgggccag  gcagcaggt  3480
scagacaag  atgagctag  acgactgca  tactccctg  attatgact  ccagagtgg  3540
caggtgggt  tggaggaag  ggaagcttt  gagggagga  cccgggggt  ccaacccct  3600
ctgaaagga  ccatggaag  gaggctaag  ctagtgttc  ccacctccc  cactgtgcc  3660
gggccctgc  gctgctggt  ggcattctg  aagcaatgg  attggcagc  ttggatctt  3720
gtggctcct  ggaccccta  gtgcgggtc  acctgctgm  ggacaaacg  aggcggtac  3780
agaccaagg  gcatcggca  acgctgaac  ctcactttg  ggagacctt  gccttcaag  3840
tgagctctg  ttcaggccc  gtgttccat  gcctgtgcc  agtccctgg  acactaggg  3900
ccgacccct  ccgcttttc  tggaggcag  cacagctca  gtggcagct  ccagctctg  3960
ggctattcc  ctggaccct  ggcactact  actcctggg  tgtagcctg  tccttgggc  4020
gtacgattt  ggttccact  acccgtgat  tttttccgc  tggatccct  gactttccc  4080
tttgagttc  cccaactgt  cgcttcgac  ctcgctgcc  cactccacg  cttccttct  4140
gttgtgctg  gcctcaccc  atctctgac  tcctgctct  tactgcgga  tctctgtgc  4200
ctccaggtm  cctacgtgg  gctgggggg  agggtgctg  tcatggcgg  gtacgactt  4260
gaccgcttc  ctcgcaatg  cgccatcgg  gaggtgcgg  tccctatga  ctccgtgga  4320
ctggggcgg  cagtgcagg  ctggcggga  ctgcaggcg  ctccgcggg  ggaggtgag  4380
atgcgcggt  gcgccccga  ccacgcccc  aggcccagt  ccgcccaca  catcctgag  4440
caatcagat  ataggcttt  cagaccctc  gggcggcgt  gattgtacc  ctgaggagg  4500
atggatgtg  agccggggc  ctggtgatg  gcccctctc  tttcagcag  agaagcttg  4560
ggacatctg  ttctccctc  gctatgtcc  cacggccgg  aagctcacc  tcatcgtcc  4620
ggaggctaa  aacctgaag  agatggacg  aggaggact  tcaggtgtg  gggaagcaa  4680
ggagtgggg  gtgagggga  ggcgtgggg  gggttctcg  tctgacagt  tctgagcct  4740
gagggtttc  tcggggaca  ggaggacct  gctgctgtg  aaggcatgg  ttttggcat  4800
gagctaggg  gacccgaag  gtgtaggca  tgtttctat  ttggtccaa  aacccagca  4860
tggggagct  taagactcc  ccttcctct  cccagatcc  tacgtcaag  tccacctgc  4920
gcagggcgg  aaaaaggtg  ggaagaaga  aaccaccat  aagaagaac  ctctgaacc  4980
ctattacaa  gaagctttc  gcttcgagg  gccctgtga  caagtccag  tgagctcaa  5040
cctgccctt  tccaagagc  cagaccttt  gtaatcgcc  ttgctaggc  gagggagac  5100
ttttagcat  tccctagaa  ccaggtgag  gggtctgag  ttatgctct  agtctgttt  5160
ctcctatga  gaccaggaa  cctcttcca  tccaggaag  gactcctta  aattgggtg  5220
gggtgtcct  tctgctcta  gcgggaccg  gatgctcca  ccctaagcg  aaccaggat  5280
tcccacccc  aagcagtac  agatgctcc  ccctaagca  gatcagtat  ccccgcccc  5340
ccaagcgga  ccaggatgc  ccgccccca  gcaggacca  gatgccccg  ccccaagca  5400
gaccaggat  ccccgcccc  aagcgggac  aggatgccc  actcctaag  gggaccaga  5460
tccccaccc  aagcaggac  aggatgccc  gccctcctc  ggaacgtgg  tctaagaaa  5520
agagacctc  cctcacttc  ttagggacg  cgcctaccc  agcccggcc  ctgttaaag  5580
tctgcagct  tgcggctct  aggaggctg  tcccccagg  ggcgccgaa  acacccgct  5640
cgcaaccga  tcctgaggg  tcatttcct  agaaacctg  ctgcgcagg  agaaaggcg  5700
cagagcctc  tcctcgccg  aggctccgt  cctctcgtc  cccaccccc  cccccgtcc  5760
gagctccgg  gccccgagc  ctcgggtgg  agcgagagg  accctcagc  gtgaaaacg  5820
acaccgccc  ttccggggc  tcctcccct  acgctcctc  ctcctcttc  tcccgcgcc  5880
accccagaa  gtgcaggtg  agctgaccg  gctggacta  gacaagctg  gcaagaacg  5940
ggccatcgg  agggtggcc  tgggggcgg  cgccggcgg  gctggcctg  ggcactggg  6000
ggacatgct  gccaacccg  ggcggccca  tgcccagtg  cactcgctg  ggcccccgg  6060
ccgagtgag  ctgctgcct  cgccctgac  cccacccca  gcccccggc  aagcctgga  6120
tctagcccc  gaccccaga  tcccgagac  ggccaaagc  aagccagcc  cacccttaa  6180
cttcctctg  cggttaccc  ccccccacc  tccacccca  ccatctgaa  cattcctgt  6240
ttctcaccc  caacgatgc  aatcacgac  actttccag  acactcccc  gaccctcgc  6300
gacacaccc  gatgcccca  ggaccccgg  aagggaagg  agcctggtt  ctcctgccc  6360
cgggtcctg  cccctgctt  gacaatcag  catcctcgt  tgctctcct  tctcttcca  6420
cacagccca  ccctgcact  ctcctgagg  caaataaat  ttcagcagc  c  6471



<210> 8145
<211> 386
<212> PRT
<213> Homo sapiens
<308> O00445
<400> 8145

Met Phe Pro Glu Pro Pro Thr Pro Gly Pro Pro Ser Pro Asp Thr Pro 
  1               5                  10                  15
Pro Asp Ser Ser Arg Ile Ser His Gly Pro Val Pro Pro Trp Ala Leu 
             20                  25                  30
Ala Thr Ile Val Leu Val Ser Gly Leu Leu Ile Phe Ser Cys Cys Phe 
         35                  40                  45
Cys Leu Tyr Arg Lys Ser Cys Arg Arg Arg Thr Gly Lys Lys Ser Gln 
     50                  55                  60
Ala Gln Ala Gln Val His Leu Gln Glu Val Lys Gly Leu Gly Gln Ser 
 65                  70                  75                  80
Tyr Ile Asp Lys Val Gln Pro Glu Val Glu Glu Leu Glu Pro Ala Pro 
                 85                  90                  95
Ser Gly Pro Gly Gln Gln Val Xaa Asp Lys His Glu Leu Gly Arg Leu 
             100                105                110
Gln Tyr Ser Leu Asp Tyr Asp Phe Gln Ser Gly Gln Leu Leu Val Gly 
         115                120                125
Ile Leu Gln Ala Met Gly Leu Ala Ala Leu Asp Leu Gly Gly Ser Ser 
     130                135                140
Asp Pro Tyr Val Arg Val Tyr Leu Leu Xaa Asp Lys Arg Arg Arg Tyr 
 145                150                155                160
Glu Thr Lys Val His Arg Gln Thr Leu Asn Pro His Phe Gly Glu Thr 
                 165                170                175
Phe Ala Phe Lys Val Pro Tyr Val Glu Leu Gly Gly Arg Val Leu Val 
             180                185                190
Met Ala Val Tyr Asp Phe Asp Arg Phe Ser Arg Asn Asp Ala Ile Gly 
         195                200                205
Glu Val Arg Val Pro Met Ser Ser Val Asp Leu Gly Arg Pro Val Gln 
     210                215                220
Ala Trp Arg Glu Leu Gln Ala Ala Pro Arg Glu Glu Gln Glu Lys Leu 
 225                230                235                240
Gly Asp Ile Cys Phe Ser Leu Arg Tyr Val Pro Thr Ala Gly Lys Leu 
                 245                250                255
Thr Val Ile Val Leu Glu Ala Lys Asn Leu Lys Lys Met Asp Val Gly 
             260                265                270
Gly Leu Ser Asp Pro Tyr Val Lys Val His Leu Leu Gln Gly Gly Lys 
         275                280                285
Lys Val Arg Lys Lys Lys Thr Thr Ile Lys Lys Asn Thr Leu Asn Pro 
     290                295                300
Tyr Tyr Asn Glu Ala Phe Ser Phe Glu Val Pro Cys Asp Gln Val Gln 
 305                310                315                320
Lys Val Gln Val Glu Leu Thr Val Leu Asp Tyr Asp Lys Leu Gly Lys 
                 325                330                335
Asn Glu Ala Ile Gly Arg Val Ala Val Gly Ala Ala Ala Gly Gly Ala 
             340                345                350
Gly Leu Arg His Trp Ala Asp Met Leu Ala Asn Pro Arg Arg Pro Ile 
         355                360                365
Ala Gln Trp His Ser Leu Arg Pro Pro Asp Arg Val Arg Leu Leu Pro 
     370                375                380
Ala Pro 
 385



<210> 8146
<211> 2807
<212> DNA
<213> Rattus norvegicus
<308> U14746
<400> 8146

ccgcgttaa  gccggacgg  gtacttcta  tgctggcag  cctgccccg  agcgcgtaa  60
cccgcacgc  cgcgccgcc  acgtccagc  cgcgaatcc  gaggcgtcc  gttccaata  120
tgccccgga  ggcagctag  ccagaggag  cagaaagga  gccgggctc  gaagagata  180
aggctgggc  gccgcggcc  gttttacgc  ctgtgaact  gcgcgaacc  tctcaggtc  240
tcttctgca  ccgcagccc  cgcgtcgtg  tgcctttgt  gctcaactt  gatggtgag  300
ctcagccct  cccgacctt  ccaccgggc  ccggccgcc  catccacag  taccgaggt  360
acctttggc  cttcaggga  gcggggacc  atgatggac  tctggttaa  caaacggaa  420
tgtttgtgc  atccctcaa  gttgatgga  agcctattt  tgccaacat  acattgcca  480
tgtataccc  gaaagagcg  tgccttcag  ttgtacgga  cctggtcaa  cctgagaac  540
acaggaggc  ggacatcgt  aggtcgctc  atgaagact  ggaagacca  ccaaatgtg  600
ggaaagaca  acagcggct  acccaagag  acctcgaga  tcaggccct  ggagaggag  660
ctgaaggag  ccactgaga  tacttggtc  tgaatttcg  ccttgatgg  ctgaaatcg  720
tctacacat  ggacaggtc  ctttctttc  gttttaaaa  ggttcattc  tggagtaaa  780
tatccatca  gtaaaagaa  gttaactaa  atcactgag  tttgtagtg  ttaagacta  840
acctgcaaa  tgccaccga  tctgccctt  ctagagcat  catcagaag  agctgtttt  900
agttttgct  cctagtaag  ctggatgtt  agcataagg  tgttagtgt  agcgattcg  960
gaggagttg  tctgtgtcc  ctaatctga  gaatacagc  tcgtatgaa  agagcccca  1020
cgctcactt  gggaaggct  agaaggccc  aatgctggg  tggacatcc  gtagaggcc  1080
agtgcctaa  gtgtgtgga  tcttcagtc  gtgttggag  aacaaacca  tgggtactt  1140
gtgggagag  tggagggcc  ggctctctg  ctgaggaaa  cttaagtgt  cacgtaaag  1200
aacaactta  cagcttctg  ttagaaaga  ctttctctt  agtttccat  tctcagcac  1260
ttctttcta  tttgttagt  tattttatt  tatttttga  acttgtgta  cccaggtca  1320
cctcagtca  tccggaggg  atgctggtc  tgaattccg  atcctctgg  agtgtgtca  1380
cattgggag  acatgggtc  accacagtc  gctctgttc  tgcttttcc  attttgaga  1440
gggctcata  tgtagccct  cctggcctc  agctagagt  agccctgtc  ccccaccca  1500
tctggctgc  tagactggg  gggcttccc  tattcactg  cccagacag  agagacgag  1560
tgtccttgt  tttaggtct  gttttgaga  ttccttctc  gaggaagct  ctggcagga  1620
cagggtttc  gttccttcc  gtcagcccc  agcattcca  ctgggcgcc  cactctgct  1680
tggcaggcg  tagttatgc  tcgatggga  aggggagtg  agctccctc  gccacacac  1740
ccaaaccat  ggtcccaga  cagtctgca  tgagtagta  tttgtgggc  gtcacagct  1800
ttcttacat  ttcaaatat  gatgttcac  acttctatc  aacattttg  agaacataa  1860
tttttattt  tttttaatt  ctcagcaga  aaaaatgag  gaagcttgg  cattgtgtg  1920
ggcacacac  agaaaggac  gtcagctga  agggtgcag  aaggctctt  tgcgctggc  1980
ctcagctgc  tgtagtcct  taacccagt  ttctctcta  tacacattt  aattggtta  2040
agcactttg  cctggccga  atcataagg  atatacagt  ttgtggcct  atttttcat  2100
gaacttcat  gttttgttt  cccctcttt  tcgtttttg  ttttgtttt  ggtttgttt  2160
ttgcttttt  ttttatcaa  atagagttt  tctgtgtag  ccaggctgt  ctggaactc  2220
ctttgtaga  caaacaact  attactggc  tcaaacgga  atctgtctg  ctctgcctc  2280
ccagtgctg  gattgaagt  tgcctaatc  tcatctaac  tagtaactt  tcttttcca  2340
gttactgca  acactgtct  aattccggt  tgctagcct  tccctttga  ggtgactgt  2400
gggagtatt  gtctcagtc  tgggctcct  gagtgcagt  tgatgctct  agatcagca  2460
aatcactga  cttaatact  acactcctg  cgccctctc  gcgtctctc  ttagtctgc  2520
gcattccgt  agtgaagcg  cacaggcca  tgtggagcc  gtgtgtggg  agtcagcag  2580
tgccgagct  ttgcaacat  ggttttatt  tttaagcct  tctctgtct  taaaagatg  2640
aatgtttgt  ttatttaac  ggaagtttg  atactgttc  ctgtgcctt  ggacatgag  2700
cacttgtcc  tgcacatcc  gtaagtgtg  tcctcagac  ttgtactct  ctttgagtt  2760
tctgaaaaa  ctgaccttt  gtacaataa  cggtgctaa  tgaagga  2807



<210> 8147
<211> 185
<212> PRT
<213> Rattus norvegicus
<308> AAA86874
<400> 8147

Met Pro Arg Lys Ala Ala Ser Pro Glu Glu Ala Glu Arg Met Pro Gly 
  1               5                  10                  15
Ser Glu Glu Ile Glu Ala Gly Arg Pro Arg Pro Val Leu Arg Ser Val 
             20                  25                  30
Asn Ser Arg Glu Pro Ser Gln Val Ile Phe Cys Asn Arg Ser Pro Arg 
         35                  40                  45
Val Val Leu Pro Leu Trp Leu Asn Phe Asp Gly Glu Pro Gln Pro Tyr 
     50                  55                  60
Pro Thr Leu Pro Pro Gly Thr Gly Arg Arg Ile His Ser Tyr Arg Gly 
 65                  70                  75                  80
His Leu Trp Leu Phe Arg Asp Ala Gly Thr His Asp Gly Leu Leu Val 
                 85                  90                  95
Asn Gln Thr Glu Leu Phe Val Pro Ser Leu Asn Val Asp Gly Gln Pro 
             100                105                110
Ile Phe Ala Asn Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu Arg Cys 
         115                120                125
Leu Gln Val Val Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg Arg Leu 
     130                135                140
Asp Ile Val Arg Ser Leu Tyr Glu Asp Leu Glu Asp His Pro Asn Val 
 145                150                155                160
Arg Lys Asp Ile Gln Arg Leu Thr Gln Glu His Leu Glu Asn Gln Ala 
                 165                170                175
Leu Gly Glu Glu Pro Glu Gly Val His 
             180                185



<210> 8148
<211> 1810
<212> DNA
<213> Homo sapiens
<308> L15409
<400> 8148

cctcgcctc  gttacaaca  cctacggtg  tggaggatc  ttctgcgca  gcgcacagc  60
tccggccgg  tatttccgc  agcgcgttc  atcctctac  gagcgcgcg  gaagactac  120
gaggtcgac  cgggagcgc  cacgcagct  cgccccgcg  ccgacccgc  gatcccgcg  180
cgtccggcc  gggtggtct  gatcgcgga  ggaatgccc  ggagggcgg  gaactggga  240
gaggccgag  taggcgcgg  ggaggcagg  gtcgaagag  acggccctg  agaagacgg  300
ggggaggag  cgggcgccg  ggagtccgg  ccggaagag  ccggcccgg  ggaactggg  360
gccgaggag  agatggagg  cgggcggcc  cggcccgtg  tgcgctcgg  gaactcgcg  420
gagccctcc  aggtcatct  ctgcaatcg  agtccgcgc  tcgtgctgc  cgtatggct  480
aacttcgac  gcgagccgc  gccctaccc  acgctgccg  ctggcacgg  ccgccgcat  540
cacagctac  gaggtcacc  ttggctctt  agagatgca  ggacacacg  tgggcttct  600
gttaaccaa  ctgaattat  tgtgccatc  ctcaatgtt  acggacagc  tatttttgc  660
aatatcaca  tgccagtgt  tactctgaa  gagcgatgc  tccaggttg  ccggagcct  720
gtcaagcct  agaattaca  gagactgga  atcgtcagg  cgctctacg  agatctgga  780
gaccaccca  atgtgcaga  agacctgga  cggctgaca  aggagcgca  tgcacatca  840
cggatggga  attgaagat  tctgttgaa  cttacactg  ttcatctca  cttttgatg  900
tactgatga  tcttgatct  gatacagga  tggttcctt  cttagtttc  aagtgtctc  960
ttctcagag  aaaataggc  ccattgctt  aaagaaagt  aactgactt  actaggcat  1020
gtgatgttt  ggggcaaac  tcacaaaat  taatttaat  cctgcccat  agagaagta  1080
ttatcagga  aaggtggtg  catttttgc  tcctagtaa  tcaggacag  ttgtatgta  1140
ggaggttta  ataagtaat  cagtgggaa  tgcagcata  cgtttaatt  taagaaggc  1200
ttggcatct  cttttaatg  atgtataat  catccattc  acatccgta  cggttggtg  1260
cttgtctgc  tcctgcttt  ggaagactg  ggcatccgt  aggcaggga  aagtctttc  1320
cctctttga  accccagtg  ctgcacatc  tgagccttc  gtcagggtt  gtcagagga  1380
caaaccagg  gacactttg  tagaaagtg  ttagaggtt  tgcctctat  tttgttggg  1440
ggtgggaga  gggacctta  aatgtgtac  gtgaacaaa  gtcttaaag  gaatcattt  1500
tgtaggaag  attttttat  attttctaa  tcgtgcact  tctcggtcc  ctcttgttg  1560
agtgctgtt  tattactgt  tctaaacta  gattgacat  ctacagttg  gataatagc  1620
tttttgtaa  ttgccatcc  cacagaaaa  acgagaaaa  ctgcatgtt  gattatagt  1680
ttaatggac  aataagttt  tgctaaatg  gagtatttc  gttcctttt  gtaaatatg  1740
gacattcct  attgatttg  gtttttttg  tgttgttgt  ttgttttgt  ttgtttttt  1800
gggatggagg  1810



<210> 8149
<211> 213
<212> PRT
<213> Homo sapiens
<308> P40337
<400> 8149

Met Pro Arg Arg Ala Glu Asn Trp Asp Glu Ala Glu Val Gly Ala Glu 
  1               5                  10                  15
Glu Ala Gly Val Glu Glu Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu 
             20                  25                  30
Ser Gly Ala Glu Glu Ser Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu 
         35                  40                  45
Gly Ala Glu Glu Glu Met Glu Ala Gly Arg Pro Arg Pro Val Leu Arg 
     50                  55                  60
Ser Val Asn Ser Arg Glu Pro Ser Gln Val Ile Phe Cys Asn Arg Ser 
 65                  70                  75                  80
Pro Arg Val Val Leu Pro Val Trp Leu Asn Phe Asp Gly Glu Pro Gln 
                 85                  90                  95
Pro Tyr Pro Thr Leu Pro Pro Gly Thr Gly Arg Arg Ile His Ser Tyr 
             100                105                110
Arg Gly His Leu Trp Leu Phe Arg Asp Ala Gly Thr His Asp Gly Leu 
         115                120                125
Leu Val Asn Gln Thr Glu Leu Phe Val Pro Ser Leu Asn Val Asp Gly 
     130                135                140
Gln Pro Ile Phe Ala Asn Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu 
 145                150                155                160
Arg Cys Leu Gln Val Val Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg 
                 165                170                175
Arg Leu Asp Ile Val Arg Ser Leu Tyr Glu Asp Leu Glu Asp His Pro 
             180                185                190
Asn Val Gln Lys Asp Leu Glu Arg Leu Thr Gln Glu Arg Ile Ala His 
         195                200                205
Gln Arg Met Gly Asp 
     210



<210> 8150
<211> 1856
<212> DNA
<213> Rattus norvegicus
<308> U15550
<400> 8150

aattccgag  tccctcaac  gggaggctt  tccgtgact  aggtcagct  ggacagcct  60
acactcaac  ggaccacag  tgatctggc  tataagcac  ttatcattc  ggtgcagga  120
gccaacaat  tagaggctg  tcagaacct  acagtatct  gtagcctca  agttgtgga  180
atcccaggc  tcaaggctg  tacccctta  agagtctcc  tctatgggg  gatccaggg  240
tatagaaca  caatgctct  tgctgatgt  tccacacgc  aagaacctg  aattggaaa  300
ttaaatatt  ctgatgtaa  tcctgagag  ttcaatctc  cctggacag  taccgaccg  360
atcttcgac  tgtttacta  cgaaattat  gattctaat  ggttgctgc  gacagcaga  420
cataatata  ctggtgctg  acgaactgc  cacatctcg  gccttccac  tagtactga  480
ttcattgtc  acctctctg  aattgctcc  agcatccgt  ccaaaacca  cagtaccac  540
gccaccaca  aagctgaac  ggaagttga  aaccttcta  tttcagatg  tactccaga  600
ggtttctgt  tgtcctgga  tgctgatga  ggcatattc  acagttttg  tatcaggat  660
agagatacc  aaaagcaat  tgaaccaca  gaaataacc  tcccttccc  cgaccgtac  720
agggacata  caggtctca  agaggccac  gagtacgaa  ttgaactct  tggaataag  780
cgtggaagg  gatcccagc  agtcagtgc  atagcaaca  cagccatgg  ctctccgaa  840
gaaatcatg  tctcagaca  cactgaaaa  gcagccaca  tcagctgga  ggcaccgac  900
gctcaggtg  agagtttcc  gattactta  gtgcctgta  caggaggtc  cccatccat  960
gtgaccgtg  atgggacgg  tactgagac  cgactggtg  ggctcaccc  tggagtgga  1020
taccacgtc  gtgtgattg  catgaaggg  tttgaagaa  gtgatccgg  ctcggggtc  1080
ctaatcaca  ctctcgatg  tccatctgg  cttctgaca  ccaacatca  agactcaga  1140
gccttggcc  tgtggcagc  ggccattgc  actgtggac  gttatgtca  ctcctacac  1200
ggggagaga  tgccagaaa  tacccgcac  gtgtctggg  atacagtgg  gttggaact  1260
catgacctg  agcctgcca  agagtacac  ctgagtgtc  ttgcagaga  aggtcacca  1320
aagagttct  ccactgcta  gaaatttac  acagacctg  attccccaa  agaattgac  1380
gctactgag  ttcagtcag  aactgcctt  ctcacctgg  gacctcccc  ggcatcggt  1440
actggatac  tcctggtct  tgagtctgt  gatggtaca  tcaaggaag  cattgtggg  1500
cctgacacc  cctcctaca  cctggcaga  ctgagccca  ccacccact  cacagcaag  1560
atccaggca  tgagtgggt  cctgaggag  aaactgatc  aaaccatct  caccacaat  1620
ggactccta  atccattcc  tagggattg  tctcaagca  tgttgaatg  cgacaccac  1680
tctggcctc  ataccatct  tataaatgg  gacaagact  aagcactgg  agtctactg  1740
gatatgacc  ctgatggag  tggatggat  gttttcctg  gacgcaaaa  tggacgtga  1800
gacttctat  gaaactgga  ggcctatgc  actgggttt  gagaccgca  agaagg  1856



<210> 8151
<211> 619
<212> PRT
<213> Rattus norvegicus
<308> AAA50761
<400> 8151

Asn Ser Glu Ile Pro Gln Leu Gly Gly Leu Ser Val Thr Glu Val Ser 
  1               5                  10                  15
Trp Asp Ser Leu Thr Leu Asn Trp Thr Thr Asp Asp Leu Ala Tyr Lys 
             20                  25                  30
His Phe Ile Ile Gln Val Gln Glu Ala Asn Asn Val Glu Ala Ala Gln 
         35                  40                  45
Asn Leu Thr Val Ser Gly Ser Leu Arg Val Val Asp Ile Pro Gly Leu 
     50                  55                  60
Lys Ala Asp Thr Pro Tyr Arg Val Ser Ile Tyr Gly Val Ile Gln Gly 
 65                  70                  75                  80
Tyr Arg Thr Pro Met Leu Ser Ala Asp Val Ser Thr Arg Lys Glu Pro 
                 85                  90                  95
Glu Ile Gly Asn Leu Asn Ile Ser Asp Val Thr Pro Glu Ser Phe Asn 
             100                105                110
Leu Ser Trp Thr Ala Thr Asp Arg Ile Phe Asp Met Phe Thr Ile Glu 
         115                120                125
Ile Ile Asp Ser Asn Arg Leu Leu Gln Thr Ala Glu His Asn Ile Ser 
     130                135                140
Gly Ala Glu Arg Thr Ala His Ile Ser Gly Leu Pro Pro Ser Thr Asp 
 145                150                155                160
Phe Ile Val Tyr Leu Ser Gly Ile Ala Pro Ser Ile Arg Thr Lys Thr 
                 165                170                175
Ile Ser Thr Thr Ala Thr Thr Glu Ala Glu Pro Glu Val Asp Asn Leu 
             180                185                190
Leu Val Ser Asp Ala Thr Pro Asp Gly Phe Cys Leu Ser Trp Thr Ala 
         195                200                205
Asp Glu Gly Ile Phe Asp Ser Phe Val Ile Arg Ile Arg Asp Thr Lys 
     210                215                220
Lys Gln Ser Glu Pro Gln Glu Ile Thr Leu Pro Ser Pro Asp Arg Thr 
 225                230                235                240
Arg Asp Ile Thr Gly Leu Arg Glu Ala Thr Glu Tyr Glu Ile Glu Leu 
                 245                250                255
Tyr Gly Ile Ser Arg Gly Arg Arg Ser Gln Pro Val Ser Ala Ile Ala 
             260                265                270
Thr Thr Ala Met Gly Ser Pro Lys Glu Ile Met Phe Ser Asp Ile Thr 
         275                280                285
Glu Asn Ala Ala Thr Val Ser Trp Arg Ala Pro Thr Ala Gln Val Glu 
     290                295                300
Ser Phe Arg Ile Thr Tyr Val Pro Val Thr Gly Gly Pro Pro Ser Met 
 305                310                315                320
Val Thr Val Asp Gly Thr Asp Thr Glu Thr Arg Leu Val Arg Leu Thr 
                 325                330                335
Pro Gly Val Glu Tyr His Val Ser Val Ile Ala Met Lys Gly Phe Glu 
             340                345                350
Glu Ser Asp Pro Val Ser Gly Ser Leu Ile Thr Ala Leu Asp Gly Pro 
         355                360                365
Ser Gly Leu Leu Thr Ala Asn Ile Thr Asp Ser Glu Ala Leu Ala Met 
     370                375                380
Trp Gln Pro Ala Ile Ala Thr Val Asp Ser Tyr Val Ile Ser Tyr Thr 
 385                390                395                400
Gly Glu Arg Val Pro Glu Ile Thr Arg Thr Val Ser Gly Asn Thr Val 
                 405                410                415
Glu Leu Glu Leu His Asp Leu Glu Pro Ala Thr Glu Tyr Thr Leu Ser 
             420                425                430
Val Phe Ala Glu Lys Gly His Gln Lys Ser Ser Thr Thr Ala Thr Lys 
         435                440                445
Phe Thr Thr Asp Leu Asp Ser Pro Arg Glu Leu Thr Ala Thr Glu Val 
     450                455                460
Gln Ser Glu Thr Ala Phe Leu Thr Trp Arg Pro Pro Arg Ala Ser Val 
 465                470                475                480
Thr Gly Tyr Leu Leu Val Tyr Glu Ser Val Asp Gly Thr Val Lys Glu 
                 485                490                495
Val Ile Val Gly Pro Asp Thr Thr Ser Tyr Ser Leu Ala Asp Leu Ser 
             500                505                510
Pro Ser Thr His Tyr Thr Ala Arg Ile Gln Ala Leu Ser Gly Ser Leu 
         515                520                525
Arg Ser Lys Leu Ile Gln Thr Ile Phe Thr Thr Ile Gly Leu Leu Tyr 
     530                535                540
Pro Phe Pro Arg Asp Cys Ser Gln Ala Met Leu Asn Gly Asp Thr Thr 
 545                550                555                560
Ser Gly Leu Tyr Thr Ile Tyr Ile Asn Gly Asp Lys Thr Gln Ala Leu 
                 565                570                575
Glu Val Tyr Cys Asp Met Thr Ser Asp Gly Gly Gly Trp Ile Val Phe 
             580                585                590
Leu Arg Arg Lys Asn Gly Arg Glu Asp Phe Tyr Arg Asn Trp Lys Ala 
         595                600                605
Tyr Ala Thr Gly Phe Gly Asp Arg Arg Glu Gly 
     610                615



<210> 8152
<211> 7286
<212> DNA
<213> Homo sapiens
<308> X56160
<400> 8152

gaattcgct  gagccctag  gccccagca  cacccagcc  aacccacct  caccatggg  60
gccatgact  agctgttgg  aggtgtctt  cttgctttc  ttgccctcg  taccgaagg  120
ggggtcctc  agaaagtca  ccggcacaa  cgacagagt  gggtgaacg  caccctgcc  180
gaagagaac  agccagtgg  gtttaacca  gtttacaac  tcaagctgc  agtgggatc  240
cagtgttcg  tggatctgg  gtcagccag  ggggagaaa  acctggcac  gccttcaga  300
cccagcgaa  gctttcagg  gcacacagt  gatggggaa  accagattg  cttcacaca  360
cgcatcaac  tcccccgcc  ggcctgtgg  tgtgccgca  cccctgatg  taaggagct  420
ctgagcaga  tggaggagc  ggagaacct  gtgtcttcc  tgagggagc  atgtactgc  480
ggagcaggc  gctgtctcc  gcctgccac  ggccgcttg  acaccaggc  cttctgtag  540
ggtcggggc  acttcagca  tgaaggatg  ggctgtgtc  gcgaacctg  ctggaaagg  600
cccaactgc  ctgagcccg  atgtccagg  aactgtcac  ttcgaggcc  gtgcattga  660
gggcagtgc  tctgtgacg  cggcttcac  ggcgaggac  gcagccagc  ggcttgccc  720
agcgactgc  atgaccagg  caagtgcgt  aatggagtc  gcatctgtt  cgaaggcta  780
gcggctgac  gcagccgtg  aatctgccc  gtgccctgc  gtgaggagc  cggcacatg  840
gtagatggc  tgtgtgtgt  ccacgatgg  tttgcaggc  atgactgca  caagcctct  900
tgtctcaac  attgctaca  ccgtggacg  tgcgtggag  atgagtgcg  gtgtgatga  960
ggtttcacg  gcgaagact  cagtgagct  atctgcccc  atgactgct  cgaccgggg  1020
cgctgcatc  atggcacct  ctactgcga  gaaggcttc  caggtgaag  ctgcgggaa  1080
cccacctgc  cacatgcct  ccacaccca  ggccggtgt  aggaggggc  gtgtgtatg  1140
gatgagggc  ttgccggtg  ggactgcag  gagaagagg  gtcctgctg  ctgtcacaa  1200
cgtggccgc  gtgtagacg  gcggtgtga  tgtgatgat  gtttcactg  agctgactg  1260
ggggagctc  agtgtccca  tggctgcag  ggccatggc  gctgtgtca  tgggcagtg  1320
gtgtgtgat  agggctata  tggggagga  tgcagccag  tacggtgcc  caatgactg  1380
cacagtcgg  gccgctgtg  cgagggcaa  tgtgtatgt  agcaaggct  caagggcta  1440
gactgcagt  acatgagct  ccctaatga  tgtcaccag  acggccgct  tgtgaatgg  1500
atgtgtgtt  gtgatgacg  ctacacagg  gaagactgc  gggatcgcc  atgccccag  1560
gactgcagc  acaggggcc  ctgtgtgga  ggacagtgc  tctgtgagg  cggcttcac  1620
ggccctgac  gtgcagaac  ctcctgtcc  aatgactgc  atggccagg  tcgctgtgt  1680
aatgggcag  gcgtgtgcc  tgaaggatt  atgggcaaa  actgcaagg  gcaaagatg  1740
cccagtgac  gtcatggcc  gggccgctg  gtggacggc  agtgcatct  ccacgaggg  1800
ttcacaggc  tggactgtg  ccagcactc  tgccccagt  actgcaaca  cttaggaca  1860
tgcgtctcg  gccgctgca  ctgcaacga  ggctacagc  gagaagact  ctcagaggt  1920
tctcctccc  aagacctcg  tgtgacaga  gtgacggaa  agacggtca  cctggcctg  1980
gacaatgag  tgcgggtca  agagtacct  gtcgtgtac  cgcccaccc  cgagggtgg  2040
ctggaaatg  agttccgtg  gcctgggga  cagacgtcc  ccatcatcc  ggagctgga  2100
cctggtgtg  agtacttta  ccgtgtatt  gccatcctg  agaacaaga  gagcattcc  2160
gtcagcgcc  gggtggcca  gtacttacc  gcacctgaa  gcctgaaat  caagtccat  2220
aaggagaca  ctgtggaag  ggagtggga  cctctagac  ttgcttttg  aacctggga  2280
atcatcttc  ggaatatga  taaagaaga  gagggagag  tcaccaaaa  cctgaggag  2340
ccagagacc  cttaccggc  aactggtct  gctcctggg  aagagtatg  gatatctct  2400
cacatagtg  aaaacaata  ccggggccc  ggcctgaag  gggtgacca  cacacgctt  2460
gatgccccc  gccagatcg  ggtgaaaga  gtcacagac  ccactgcct  gatcacctg  2520
ttcaagccc  tggctgaga  cgatggcat  gagctgacc  acggcatca  agacgtgcc  2580
ggagaccgt  ccaccatcg  tctcacaga  gacgagaac  agtactcca  cgggaacct  2640
aagcctgac  ctgagtacg  ggtgtccct  atctcccgc  gaggtgaca  gtcaagcaa  2700
ccagccaaa  agaccttca  aacaggcct  gatgctccc  ggaatcttc  acgtgtttc  2760
cagacagat  acagcatca  cctggaatg  aggaatggc  aggcagcta  tgacagtta  2820
agaattaag  atgccccca  ctctggagg  gaccacgct  aggttgatg  tccaaagag  2880
caacaagcc  caaccaaaa  cacactcac  ggtctgagg  cgggaactg  atatgggat  2940
ggagtttct  ctgtgaagg  agacaagga  agcaatcca  cgaccatca  cgcagccac  3000
gagttggac  cgcccaagg  ccttcaggt  tctgaaact  cagagacca  cctgaccct  3060
ctctggaag  caccgttgg  caaatttga  cgctaccgc  tcaattaca  tctccccac  3120
ggccagtgg  tgggagtgc  gcttccaag  aacaccact  cctatgtcc  gagaggcct  3180
gaaccagga  aggagtaca  tgtcctcct  acagccgag  aaggcagac  caagagcaa  3240
cccgcacgt  tgaaggcat  cactgaaca  gcccctgag  tggaaaacc  caccgtgac  3300
gaggttggc  gggatggcc  cagactcaa  tggaccgcg  ctgaccagg  ctatgagca  3360
tttatcatt  aggtgcagg  ggccaacaa  gtggaggca  ctcggaacc  caccgtgcc  3420
ggcagcctt  gggctgtgg  cataccggg  ctcaaggct  ctacgcctt  tacagtctc  3480
atctatggg  tgatccagg  ctatagaac  ccagtgctc  ctgctgagg  ctccacagg  3540
gaaactccc  atttgggag  ggtcgtggt  gccgaggtg  gctgggatg  cctcaaact  3600
aactggact  ctccagaag  ggcctatga  tactttttc  ttcaggtgc  ggaggctga  3660
acagtagag  cagcccaga  cctcaccgt  ccaggagga  tgaggtcca  agacctgcc  3720
gggctcaaa  cagccactc  ttataccat  accatccgc  gggtcactc  ggacttcag  3780
acaacccct  tctctgttg  agtcttgac  gaggaggtt  cagatatgg  aaacctcac  3840
gtgaccgag  ttagctggg  tgctctcag  ctgaactgg  ccacgccag  tggaaccta  3900
gaccagttt  ctattcagg  ccaggaggc  gaccaggtg  aagaggctc  caatctcac  3960
gttcctggc  gcctgcgtt  catggaaat  ccaggcctc  gggctggca  tccttacac  4020
gtcaccctg  acggcgagg  caggggcca  agcactcga  cccttgctg  agaggtcgt  4080
acagaggat  tcccacagc  gggagattt  gccgtgtct  aggttggct  ggatggcct  4140
agactcaac  ggaccgcag  tgacaatgc  tatgagcac  ttgtcattc  ggtgcagga  4200
gtcaacaaa  tggaggcag  ccagaacct  acgttgcct  gcagcctca  ggctgtgga  4260
atcccgggc  tcgaggctg  cacgcctta  agagtctcc  tctatgggg  gatccgggg  4320
tatagaaca  cagtactct  tgctgaggc  tccacagcc  aagaacctg  aattggaaa  4380
ttaaatgtt  ctgacataa  tcccgagag  ttcaatctc  cctggatgg  taccgatgg  4440
atcttcgag  cctttacca  tgaaattat  gattccaat  ggttgctgg  gactgtgga  4500
tataatatc  ctggtgctg  acgaactgc  catatctca  ggctacccc  tagtactga  4560
tttattgtc  acctctctg  acttgctcc  agcatccgg  ccaaaacca  cagtgccac  4620
gccacgaca  aggccctgc  ccttctgga  aacctaacc  tttccgaca  taatcccta  4680
gggttcaca  tttcctgga  ggcatcgga  aatgccttt  acagctttc  agtaacggt  4740
gtggattct  ggaagctgc  ggaccccca  gaattcaca  tttcaggaa  ccagaggaa  4800
ctggagctt  gaggcctca  aactggcat  ggctatgag  ttatggtct  tggcttcac  4860
caagggcat  aaaccaagc  cttgagggc  gagattgtt  cagaagccg  accggaagt  4920
gacaacctt  tggtttcag  tgccacccc  gacggtttc  gtctgtcct  gacagctga  4980
gaaggggtc  tcgacaatt  tgttctcaa  atcagagat  ccaaaaagc  gtctgagcc  5040
ctggaaata  ccctacttg  ccccgaacg  accagggac  taacaggtc  cagagaggc  5100
actgaatac  aaattgaac  ctatggaat  agcaaagga  ggcgatccc  gacagtcag  5160
gctatagca  caacagcca  gggctcccc  aaggaagtc  ttttctcag  catcactga  5220
aattcggct  ctgtcagct  gagggcacc  acggcccaa  tggagagct  ccggattac  5280
tatgtgccc  ttacaggag  tacaccctc  atggtaact  tggacggaa  caagactca  5340
accaggctg  tgaaactca  acctggcgt  gagtacctt  tcagcatca  cgccatgaa  5400
ggctttgag  aaagtgaac  tgtctcagg  tcattcacc  cagctctgg  tggcccatc  5460
ggcctggtg  cagccaaca  cactgactc  gaagccttg  ccaggtggc  gccagccat  5520
gccactgtg  acagttatg  catctccta  acaggcgag  aagtgccag  aattacacg  5580
acggtgtcc  ggaacacag  ggagtatgc  ctgaccgac  tcgagcctg  cacggaata  5640
acactgaga  tctttgcag  gaaagggcc  cagaagagc  caaccatca  tgccaagtt  5700
acaacagac  tcgattctc  aagagactt  actgctact  aggttcagt  ggaaactgc  5760
ctccttacc  ggcgacccc  ccgggcatc  gtcaccggt  acctgctgg  ctatgaatc  5820
gtggatggc  cagtcaagg  agtcattgt  ggtccagat  ccacctcct  cagcctggc  5880
gacctgagc  catccaccc  ctacacagc  aagatccag  cactcaatg  gcccctgag  5940
agcaatatg  tccagacca  cttcaccac  attggactc  tgtacccct  ccccaagga  6000
tgctcccaa  caatgctga  tggagacac  acctctggc  tctacacca  ttatctgaa  6060
ggtgataag  ctcaggcgc  ggaagtctt  tgtgacatg  cctctgatg  gggtggatg  6120
attgtgttc  tgagacgca  aaacggacg  gagaacttc  accaaaact  gaaggcata  6180
gctgctgga  ttggggacc  cagagaaga  ttctggctt  ggctggaca  cctgaacaa  6240
atcacagcc  aggggcagt  cgagctccg  gtggacctg  gggaccatg  ggagacagc  6300
tttgctgtc  atgacaagt  cagcgtggg  gatgccaag  ctcgctaca  gctgaaggt  6360
gaggggtac  gtgggacag  aggtgactc  atggcctac  acaatggca  atccttctc  6420
acctttgac  aggacacag  ttcagccat  accaactgt  ctctgtcta  aaggggctt  6480
tggtacagg  actgtcacc  tgtcaacct  atggggaga  atggggaca  taaccacag  6540
cagggcgtt  actggttcc  ctggaaggg  cacgaacac  caatccagt  tgctgagat  6600
aagctgaga  caagcaact  cagaaatct  gaaggcagg  gcaaacggg  ataaattgg  6660
gggaccact  ggtgagaga  gaataaggc  gcccagagc  aggaaagga  tttaccaaa  6720
catcaatac  accagccca  ccatcggtc  acacctggg  atttggtga  aatcaaagc  6780
gaccatgga  ccctggggc  aacggcaac  gcatgggcc  cacctcctc  gtgatttct  6840
tctttgcac  aaagacatc  gtctccaac  tgtttctgt  ttgttgttt  attcagcaa  6900
aatctccca  tgacaacat  gcaatagtt  tttacttct  ttaggtggc  ctgggatgg  6960
agaggggta  gatgtacag  ggtagtttg  tttagaacc  gccgtattt  acatgaagc  7020
gtataatta  ttgtcatta  ttttgttag  aaagattaa  tgtgtcatt  gaagccatc  7080
cttttttta  atttcatac  acagaaacc  gaaaagcaa  actgtttcc  ttttaagga  7140
atgattaat  ttattaata  aataatgat  atgatgatg  tgaaaacta  ggatttttc  7200
agagatctt  ctttccaaa  catttctgg  cagtacctg  ttgtatttt  tttttaaat  7260
aaagcacaa  tacttttga  aaaaaa  7286



<210> 8153
<211> 2201
<212> PRT
<213> Homo sapiens
<308> P24821
<400> 8153

Met Gly Ala Met Thr Gln Leu Leu Ala Gly Val Phe Leu Ala Phe Leu 
  1               5                  10                  15
Ala Leu Ala Thr Glu Gly Gly Val Leu Lys Lys Val Ile Arg His Lys 
             20                  25                  30
Arg Gln Ser Gly Val Asn Ala Thr Leu Pro Glu Glu Asn Gln Pro Val 
         35                  40                  45
Val Phe Asn His Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys 
     50                  55                  60
Ser Val Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro 
 65                  70                  75                  80
Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn 
                 85                  90                  95
Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly 
             100                105                110
Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu 
         115                120                125
Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Ala Gly Ala 
     130                135                140
Gly Cys Cys Leu Gln Pro Ala Thr Gly Arg Leu Asp Thr Arg Pro Phe 
 145                150                155                160
Cys Ser Gly Arg Gly Asn Phe Ser Thr Glu Gly Cys Gly Cys Val Cys 
                 165                170                175
Glu Pro Gly Trp Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly 
             180                185                190
Asn Cys His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp 
         195                200                205
Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp 
     210                215                220
Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe Glu 
 225                230                235                240
Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys Pro Val Pro Cys 
                 245                250                255
Ser Glu Glu His Gly Thr Cys Val Asp Gly Leu Cys Val Cys His Asp 
             260                265                270
Gly Phe Ala Gly Asp Asp Cys Asn Lys Pro Leu Cys Leu Asn Asn Cys 
         275                280                285
Tyr Asn Arg Gly Arg Cys Val Glu Asn Glu Cys Val Cys Asp Glu Gly 
     290                295                300
Phe Thr Gly Glu Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe 
 305                310                315                320
Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe 
                 325                330                335
Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr 
             340                345                350
Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu Gly Phe Ala 
         355                360                365
Gly Leu Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp Cys His Asn Arg 
     370                375                380
Gly Arg Cys Val Asp Gly Arg Cys Glu Cys Asp Asp Gly Phe Thr Gly 
 385                390                395                400
Ala Asp Cys Gly Glu Leu Lys Cys Pro Asn Gly Cys Ser Gly His Gly 
                 405                410                415
Arg Cys Val Asn Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu 
             420                425                430
Asp Cys Ser Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg 
         435                440                445
Cys Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp 
     450                455                460
Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys 
 465                470                475                480
Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr Gly Glu Asp Cys 
                 485                490                495
Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser Asn Arg Gly Leu Cys Val 
             500                505                510
Asp Gly Gln Cys Val Cys Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala 
         515                520                525
Glu Leu Ser Cys Pro Asn Asp Cys His Gly Gln Gly Arg Cys Val Asn 
     530                535                540
Gly Gln Cys Val Cys His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu 
 545                550                555                560
Gln Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly 
                 565                570                575
Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His 
             580                585                590
Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser Gly Arg 
         595                600                605
Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys Ser Glu Val Ser 
     610                615                620
Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val Asn 
 625                630                635                640
Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val Tyr 
                 645                650                655
Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly 
             660                665                670
Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr 
         675                680                685
Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val 
     690                695                700
Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe 
 705                710                715                720
Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp 
                 725                730                735
Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu 
             740                745                750
Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr 
         755                760                765
Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His 
     770                775                780
Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr 
 785                790                795                800
Thr Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp 
                 805                810                815
Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly 
             820                825                830
Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
         835                840                845
Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys 
     850                855                860
Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met 
 865                870                875                880
Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Leu Asp Ala Pro 
                 885                890                895
Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu 
             900                905                910
Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala 
         915                920                925
Pro Ile Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln 
     930                935                940
Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu 
 945                950                955                960
Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser Asn Pro 
                 965                970                975
Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys Asp Leu Gln 
             980                985                990
Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu Leu Trp Lys Thr Pro 
         995                1000                1005
Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr Ser Leu Pro Thr Gly 
     1010                1015                1020
Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr Thr Ser Tyr Val Leu 
 1025                1030                1035                1040
Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val Leu Leu Thr Ala Glu 
                 1045                1050                1055
Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val Lys Ala Ser Thr Glu 
             1060                1065                1070
Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr Glu Val Gly Trp Asp 
         1075                1080                1085
Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp Gln Ala Tyr Glu His Phe 
     1090                1095                1100
Ile Ile Gln Val Gln Glu Ala Asn Lys Val Glu Ala Ala Arg Asn Leu 
 1105                1110                1115                1120
Thr Val Pro Gly Ser Leu Arg Ala Val Asp Ile Pro Gly Leu Lys Ala 
                 1125                1130                1135
Ala Thr Pro Tyr Thr Val Ser Ile Tyr Gly Val Ile Gln Gly Tyr Arg 
             1140                1145                1150
Thr Pro Val Leu Ser Ala Glu Ala Ser Thr Gly Glu Thr Pro Asn Leu 
         1155                1160                1165
Gly Glu Val Val Val Ala Glu Val Gly Trp Asp Ala Leu Lys Leu Asn 
     1170                1175                1180
Trp Thr Ala Pro Glu Gly Ala Tyr Glu Tyr Phe Phe Ile Gln Val Gln 
 1185                1190                1195                1200
Glu Ala Asp Thr Val Glu Ala Ala Gln Asn Leu Thr Val Pro Gly Gly 
                 1205                1210                1215
Leu Arg Ser Thr Asp Leu Pro Gly Leu Lys Ala Ala Thr His Tyr Thr 
             1220                1225                1230
Ile Thr Ile Arg Gly Val Thr Gln Asp Phe Ser Thr Thr Pro Leu Ser 
         1235                1240                1245
Val Glu Val Leu Thr Glu Glu Val Pro Asp Met Gly Asn Leu Thr Val 
     1250                1255                1260
Thr Glu Val Ser Trp Asp Ala Leu Arg Leu Asn Trp Thr Thr Pro Asp 
 1265                1270                1275                1280
Gly Thr Tyr Asp Gln Phe Thr Ile Gln Val Gln Glu Ala Asp Gln Val 
                 1285                1290                1295
Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser Leu Arg Ser Met Glu 
             1300                1305                1310
Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr Val Thr Leu His Gly 
         1315                1320                1325
Glu Val Arg Gly His Ser Thr Arg Pro Leu Ala Val Glu Val Val Thr 
     1330                1335                1340
Glu Asp Leu Pro Gln Leu Gly Asp Leu Ala Val Ser Glu Val Gly Trp 
 1345                1350                1355                1360
Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp Asn Ala Tyr Glu His 
                 1365                1370                1375
Phe Val Ile Gln Val Gln Glu Val Asn Lys Val Glu Ala Ala Gln Asn 
             1380                1385                1390
Leu Thr Leu Pro Gly Ser Leu Arg Ala Val Asp Ile Pro Gly Leu Glu 
         1395                1400                1405
Ala Ala Thr Pro Tyr Arg Val Ser Ile Tyr Gly Val Ile Arg Gly Tyr 
     1410                1415                1420
Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr Ala Lys Glu Pro Glu 
 1425                1430                1435                1440
Ile Gly Asn Leu Asn Val Ser Asp Ile Thr Pro Glu Ser Phe Asn Leu 
                 1445                1450                1455
Ser Trp Met Ala Thr Asp Gly Ile Phe Glu Thr Phe Thr Ile Glu Ile 
             1460                1465                1470
Ile Asp Ser Asn Arg Leu Leu Glu Thr Val Glu Tyr Asn Ile Ser Gly 
         1475                1480                1485
Ala Glu Arg Thr Ala His Ile Ser Gly Leu Pro Pro Ser Thr Asp Phe 
     1490                1495                1500
Ile Val Tyr Leu Ser Gly Leu Ala Pro Ser Ile Arg Thr Lys Thr Ile 
 1505                1510                1515                1520
Ser Ala Thr Ala Thr Thr Glu Ala Leu Pro Leu Leu Glu Asn Leu Thr 
                 1525                1530                1535
Ile Ser Asp Ile Asn Pro Tyr Gly Phe Thr Val Ser Trp Met Ala Ser 
             1540                1545                1550
Glu Asn Ala Phe Asp Ser Phe Leu Val Thr Val Val Asp Ser Gly Lys 
         1555                1560                1565
Leu Leu Asp Pro Gln Glu Phe Thr Leu Ser Gly Thr Gln Arg Lys Leu 
     1570                1575                1580
Glu Leu Arg Gly Leu Ile Thr Gly Ile Gly Tyr Glu Val Met Val Ser 
 1585                1590                1595                1600
Gly Phe Thr Gln Gly His Gln Thr Lys Pro Leu Arg Ala Glu Ile Val 
                 1605                1610                1615
Thr Glu Ala Glu Pro Glu Val Asp Asn Leu Leu Val Ser Asp Ala Thr 
             1620                1625                1630
Pro Asp Gly Phe Arg Leu Ser Trp Thr Ala Asp Glu Gly Val Phe Asp 
         1635                1640                1645
Asn Phe Val Leu Lys Ile Arg Asp Thr Lys Lys Gln Ser Glu Pro Leu 
     1650                1655                1660
Glu Ile Thr Leu Leu Ala Pro Glu Arg Thr Arg Asp Leu Thr Gly Leu 
 1665                1670                1675                1680
Arg Glu Ala Thr Glu Tyr Glu Ile Glu Leu Tyr Gly Ile Ser Lys Gly 
                 1685                1690                1695
Arg Arg Ser Gln Thr Val Ser Ala Ile Ala Thr Thr Ala Met Gly Ser 
             1700                1705                1710
Pro Lys Glu Val Ile Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr Val 
         1715                1720                1725
Ser Trp Arg Ala Pro Thr Ala Gln Val Glu Ser Phe Arg Ile Thr Tyr 
     1730                1735                1740
Val Pro Ile Thr Gly Gly Thr Pro Ser Met Val Thr Val Asp Gly Thr 
 1745                1750                1755                1760
Lys Thr Gln Thr Arg Leu Val Lys Leu Ile Pro Gly Val Glu Tyr Leu 
                 1765                1770                1775
Val Ser Ile Ile Ala Met Lys Gly Phe Glu Glu Ser Glu Pro Val Ser 
             1780                1785                1790
Gly Ser Phe Thr Thr Ala Leu Asp Gly Pro Ser Gly Leu Val Thr Ala 
         1795                1800                1805
Asn Ile Thr Asp Ser Glu Ala Leu Ala Arg Trp Gln Pro Ala Ile Ala 
     1810                1815                1820
Thr Val Asp Ser Tyr Val Ile Ser Tyr Thr Gly Glu Lys Val Pro Glu 
 1825                1830                1835                1840
Ile Thr Arg Thr Val Ser Gly Asn Thr Val Glu Tyr Ala Leu Thr Asp 
                 1845                1850                1855
Leu Glu Pro Ala Thr Glu Tyr Thr Leu Arg Ile Phe Ala Glu Lys Gly 
             1860                1865                1870
Pro Gln Lys Ser Ser Thr Ile Thr Ala Lys Phe Thr Thr Asp Leu Asp 
         1875                1880                1885
Ser Pro Arg Asp Leu Thr Ala Thr Glu Val Gln Ser Glu Thr Ala Leu 
     1890                1895                1900
Leu Thr Trp Arg Pro Pro Arg Ala Ser Val Thr Gly Tyr Leu Leu Val 
 1905                1910                1915                1920
Tyr Glu Ser Val Asp Gly Thr Val Lys Glu Val Ile Val Gly Pro Asp 
                 1925                1930                1935
Thr Thr Ser Tyr Ser Leu Ala Asp Leu Ser Pro Ser Thr His Tyr Thr 
             1940                1945                1950
Ala Lys Ile Gln Ala Leu Asn Gly Pro Leu Arg Ser Asn Met Ile Gln 
         1955                1960                1965
Thr Ile Phe Thr Thr Ile Gly Leu Leu Tyr Pro Phe Pro Lys Asp Cys 
     1970                1975                1980
Ser Gln Ala Met Leu Asn Gly Asp Thr Thr Ser Gly Leu Tyr Thr Ile 
 1985                1990                1995                2000
Tyr Leu Asn Gly Asp Lys Ala Gln Ala Leu Glu Val Phe Cys Asp Met 
                 2005                2010                2015
Thr Ser Asp Gly Gly Gly Trp Ile Val Phe Leu Arg Arg Lys Asn Gly 
             2020                2025                2030
Arg Glu Asn Phe Tyr Gln Asn Trp Lys Ala Tyr Ala Ala Gly Phe Gly 
         2035                2040                2045
Asp Arg Arg Glu Glu Phe Trp Leu Gly Leu Asp Asn Leu Asn Lys Ile 
     2050                2055                2060
Thr Ala Gln Gly Gln Tyr Glu Leu Arg Val Asp Leu Arg Asp His Gly 
 2065                2070                2075                2080
Glu Thr Ala Phe Ala Val Tyr Asp Lys Phe Ser Val Gly Asp Ala Lys 
                 2085                2090                2095
Thr Arg Tyr Lys Leu Lys Val Glu Gly Tyr Ser Gly Thr Ala Gly Asp 
             2100                2105                2110
Ser Met Ala Tyr His Asn Gly Arg Ser Phe Ser Thr Phe Asp Lys Asp 
         2115                2120                2125
Thr Asp Ser Ala Ile Thr Asn Cys Ala Leu Ser Tyr Lys Gly Ala Phe 
     2130                2135                2140
Trp Tyr Arg Asn Cys His Arg Val Asn Leu Met Gly Arg Tyr Gly Asp 
 2145                2150                2155                2160
Asn Asn His Ser Gln Gly Val Asn Trp Phe His Trp Lys Gly His Glu 
                 2165                2170                2175
His Ser Ile Gln Phe Ala Glu Met Lys Leu Arg Pro Ser Asn Phe Arg 
             2180                2185                2190
Asn Leu Glu Gly Arg Arg Lys Arg Ala 
         2195                2200



<210> 8154
<211> 2019
<212> DNA
<213> Rattus norvegicus
<308> U15734
<400> 8154

cgctccgcc  acgcgacag  ggggcggcg  gcatgtggg  aacgcagta  tcgccagac  60
tcaggctgt  actgtggcg  cccggccgt  gccaccgca  ccgctgacg  cccccgctc  120
ccacatgca  cgccgcccc  ctgtggcct  cggtgaagc  aggctgcca  gcccgggct  180
cgcctgcct  cctcctcgc  gctttccgc  tcctcggcg  gcgggcgcg  tgcggctgg  240
cccaaggcc  gcggtgctg  ggctgctgc  gctgctgta  gccgcggtg  ccggcgcca  300
caaggcgga  gagctgcat  acccgcagg  cgagcaccg  gcggactac  accgcgaag  360
gctgctagg  gtccaggaa  acgtcgacg  gtatgttaa  cttggccac  aagagcagc  420
aagacgatt  cagtcgatc  taaagaaaa  tgactcgga  tctgatggc  ttctcactg  480
aaatgaact  agtcagtgg  ttcagatgt  gtttaagca  tacgccatg  aagaagcca  540
gcagcagtt  gtggagtat  acaagaaca  cgacggcac  gtgacgtgg  atgagtaca  600
cgtccagat  tatgaccgc  tgattgact  tgacgagaa  actgctctg  atgacaccg  660
ggaggagtc  tttaggcag  tccatctaa  ggataagaa  cgatttgaa  aagctaacc  720
ggattctgg  cctggtctg  atcttgaag  gtttattgc  tttgaacac  cagaagaag  780
tgactatat  acggagttc  tcattcagg  ggctttgga  gagcatgac  aaaatggtg  840
tgggtttgt  agtctggaa  aatttcttg  cgattacag  cgggatcca  ctgcaaatg  900
agacccaga  tggatactt  ttgaaaagg  cagatttgt  aatgattat  acaaagaca  960
cgatggccg  cttgatccc  aagagctgt  gtcctgggt  gtgcccaat  accagggca  1020
tgcccaaga  gaagctctt  atctgattg  tgagatgga  ttgaatagt  acaaaaagc  1080
ctcggaaga  gagattctg  aaaaccaag  cttgtttct  accagcgaa  ccacggatt  1140
tggcagaca  ctccacgat  actatttct  tcacgatga  ctttaaagc  ggaagggcc  1200
tttgtagtt  gctaccagc  ttacattta  gataaaata  ggatgttgt  ttttacact  1260
ctaagtctt  ccacatcag  tgacctaaa  atagattat  acttttggc  ttttagaag  1320
aaaacaaga  cttgtcatt  atttcaaga  gtattgaag  agtaaacat  gatattgtg  1380
catatgacc  cacagtctc  cctaagtac  ccatctatg  agtgctgtg  tgtggaatg  1440
ttgagccct  tttccatac  tgaagacat  gaggacttt  aacatgtct  aacaatagt  1500
tttaagtag  acgtgatga  gctgtcagt  ttcgttctt  tactcgtag  cttcctttt  1560
aaactgacg  aggacagtg  gtttagctt  agtgttata  cttaaaacc  ttaaaggaa  1620
cttcagaag  acttaaacc  cacatagat  tcgagaagg  tctactaat  taaaatggt  1680
tctaaaaag  gttttgttg  atgaaatag  actttatat  tttgcatat  tataaatag  1740
aattatatt  aatgtataa  aatagcatt  tggtgagtg  gaattgaca  tgtccagaa  1800
tcttcaatt  tgattgatt  aaaataaac  gtcctatct  tttatatgt  tgggttttt  1860
ttaattttt  cagataaat  ttaaattca  catgggttt  attatattc  acattattc  1920
ttcctttat  aggtagtga  tgttcttga  attgttaat  attgttggt  catagtctt  1980
cttgccttt  tttttttaa  taaaaagaa  tatgctata  2019



<210> 8155
<211> 318
<212> PRT
<213> Rattus norvegicus
<308> Q62703
<400> 8155

Met Arg Leu Gly Pro Arg Pro Ala Val Leu Gly Leu Leu Leu Leu Leu 
  1               5                  10                  15
Tyr Ala Ala Val Ala Gly Ala Ser Lys Ala Glu Glu Leu His Tyr Pro 
             20                  25                  30
Gln Gly Glu His Arg Ala Asp Tyr Asp Arg Glu Ala Leu Leu Gly Val 
         35                  40                  45
Gln Glu Asp Val Asp Glu Tyr Val Lys Leu Gly His Glu Glu Gln Gln 
     50                  55                  60
Arg Arg Leu Gln Ser Ile Ile Lys Lys Ile Asp Ser Asp Ser Asp Gly 
 65                  70                  75                  80
Phe Leu Thr Glu Asn Glu Leu Ser Gln Trp Ile Gln Met Ser Phe Lys 
                 85                  90                  95
His Tyr Ala Met Gln Glu Ala Lys Gln Gln Phe Val Glu Tyr Asp Lys 
             100                105                110
Asn Ser Asp Gly Thr Val Thr Trp Asp Glu Tyr Asn Val Gln Met Tyr 
         115                120                125
Asp Arg Val Ile Asp Phe Asp Glu Asn Thr Ala Leu Asp Asp Thr Glu 
     130                135                140
Glu Glu Ser Phe Arg Gln Leu His Leu Lys Asp Lys Lys Arg Phe Glu 
 145                150                155                160
Lys Ala Asn Gln Asp Ser Gly Pro Gly Leu Asn Leu Glu Glu Phe Ile 
                 165                170                175
Ala Phe Glu His Pro Glu Glu Val Asp Tyr Met Thr Glu Phe Val Ile 
             180                185                190
Gln Glu Ala Leu Glu Glu His Asp Lys Asn Gly Asp Gly Phe Val Ser 
         195                200                205
Leu Glu Glu Phe Leu Gly Asp Tyr Arg Arg Asp Pro Thr Ala Asn Glu 
     210                215                220
Asp Pro Glu Trp Ile Leu Val Glu Lys Asp Arg Phe Val Asn Asp Tyr 
 225                230                235                240
Asp Lys Asp Ser Asp Gly Arg Leu Asp Pro Gln Glu Leu Leu Ser Trp 
                 245                250                255
Val Val Pro Asn Asn Gln Gly Ile Ala Gln Glu Glu Ala Leu His Leu 
             260                265                270
Ile Asp Glu Met Asp Leu Asn Ser Asp Lys Lys Leu Ser Glu Glu Glu 
         275                280                285
Ile Leu Glu Asn Gln Asp Leu Phe Leu Thr Ser Glu Ala Thr Asp Tyr 
     290                295                300
Gly Arg Gln Leu His Asp Asp Tyr Phe Tyr His Asp Glu Leu 
 305                310                315



<210> 8156
<211> 1700
<212> DNA
<213> Homo sapiens
<308> X78669
<400> 8156

gcagccgcc  gggcccccg  cagcctccc  cctcgcgtc  ctcggtgtc  tccgcgggc  60
ggcgcgatg  ggctgggcc  gaggaccgc  gcgttgggg  tgctgctgc  gtgcgccgc  120
gcggccggc  ccggcaagg  cgaggagct  cactacccg  tgggcgagc  ccgcagcga  180
tacgaccgc  aggcgctgc  gggcgtcca  gaagatgtg  atgaatatg  taaactcgg  240
cacgaagag  agcaaaaaa  actgcaggc  atcataaag  aaatcgact  ggactcaga  300
ggctttctc  ctgaaagtg  actcagttc  tggattcag  tgtctttta  gcattatgc  360
atgcaagaa  caaaacaac  gtttgttga  tatgataaa  acagtgatg  tactgtgac  420
tgggatgaa  ataacattc  gatgtatga  cgtgtgatt  actttgatg  gaacactgc  480
ctggatgat  cagaagagg  gtcctttag  aagcttcac  taaaggaca  gaagcgatt  540
gaaaaagct  accaggatt  aggtcccgg  ttgagtctt  aagaattta  tgcttttga  600
catcctgaa  aagttgatt  tatgacgga  tttgtcatt  aagaagctt  agaagaaca  660
gacaaaaat  gtgatggat  tgttagttt  gaagaattt  ttggtgatt  caggtggga  720
ccaactgca  atgaagatc  agaatggat  cttgttgag  aagacagat  cgtgaatga  780
tatgacaaa  ataacgatg  caggcttga  ccccaagag  tgttacctt  ggtagtacc  840
aataatcag  gcattgcac  agaggaggc  cttcatcta  ttgatgaaa  ggatttgaa  900
ggtgacaaa  agctctctg  agaagagat  ctggaaaac  cggacttgt  tctcaccag  960
gaagccaca  attatggca  acagctcca  gatgactat  tctatcatg  tgagcttta  1020
tctccgagc  tgtctcagt  gagtactgg  tccttttat  atttgttac  agctttact  1080
ttgtgataa  atattgatg  tgtatttta  actcttaag  cttaaccac  gtcagaatt  1140
tcttaatgt  gaattataa  tttggctct  ttaggaaaa  acaaaatct  atatttttc  1200
aaacgtatt  agcaacaaa  tattaatat  gtgccatat  acaacaaag  ctttcctaa  1260
tactccatc  gtttagtac  gtattgtgg  atatttgag  tctatttcc  gacttgaaa  1320
catggagga  tttagagat  cctgaacaa  attatttaa  tagtatgtg  ccgagctat  1380
aattttttg  ttttgttct  agtagattt  atttgggaa  tgacaggac  atgttttta  1440
gtttagcat  ttgtttaaa  acctttaaa  aaaccttta  aaggactta  acctcacat  1500
ttaatgttg  gaagttctg  ttaatttta  aatggtttc  ataaagggt  ttattgtat  1560
aaatagaac  ttatatttt  gcatatgta  agaggataa  tatatttaa  gtataacta  1620
agcattatg  tgagtggaa  ttgacattg  ccaaacctt  ttcattttt  agtgattaa  1680
aatgaaatg  cctttgtaaa  1700



<210> 8157
<211> 317
<212> PRT
<213> Homo sapiens
<308> Q14257
<400> 8157

Met Arg Leu Gly Pro Arg Thr Ala Ala Leu Gly Leu Leu Leu Leu Cys 
  1               5                  10                  15
Ala Ala Ala Ala Gly Ala Gly Lys Ala Glu Glu Leu His Tyr Pro Leu 
             20                  25                  30
Gly Glu Arg Arg Ser Asp Tyr Asp Arg Glu Ala Leu Leu Gly Val Gln 
         35                  40                  45
Glu Asp Val Asp Glu Tyr Val Lys Leu Gly His Glu Glu Gln Gln Lys 
     50                  55                  60
Arg Leu Gln Ala Ile Ile Lys Lys Ile Asp Leu Asp Ser Asp Gly Phe 
 65                  70                  75                  80
Leu Thr Glu Ser Glu Leu Ser Ser Trp Ile Gln Met Ser Phe Lys His 
                 85                  90                  95
Tyr Ala Met Gln Glu Ala Lys Gln Gln Phe Val Glu Tyr Asp Lys Asn 
             100                105                110
Ser Asp Asp Thr Val Thr Trp Asp Glu Tyr Asn Ile Gln Met Tyr Asp 
         115                120                125
Arg Val Ile Asp Phe Asp Glu Asn Thr Ala Leu Asp Asp Ala Glu Glu 
     130                135                140
Glu Ser Phe Arg Lys Leu His Leu Lys Asp Lys Lys Arg Phe Glu Lys 
 145                150                155                160
Ala Asn Gln Asp Ser Gly Pro Gly Leu Ser Leu Glu Glu Phe Ile Ala 
                 165                170                175
Phe Glu His Pro Glu Glu Val Asp Tyr Met Thr Glu Phe Val Ile Gln 
             180                185                190
Glu Ala Leu Glu Glu His Asp Lys Asn Gly Asp Gly Phe Val Ser Leu 
         195                200                205
Glu Glu Phe Leu Gly Asp Tyr Arg Trp Asp Pro Thr Ala Asn Glu Asp 
     210                215                220
Pro Glu Trp Ile Leu Val Glu Lys Asp Arg Phe Val Asn Asp Tyr Asp 
 225                230                235                240
Lys Asp Asn Asp Gly Arg Leu Asp Pro Gln Glu Leu Leu Pro Trp Val 
                 245                250                255
Val Pro Asn Asn Gln Gly Ile Ala Gln Glu Glu Ala Leu His Leu Ile 
             260                265                270
Asp Glu Met Asp Leu Asn Gly Asp Lys Lys Leu Ser Glu Glu Glu Ile 
         275                280                285
Leu Glu Asn Pro Asp Leu Phe Leu Thr Ser Glu Ala Thr Asp Tyr Gly 
     290                295                300
Arg Gln Leu His Asp Asp Tyr Phe Tyr His Asp Glu Leu 
 305                310                315



<210> 8158
<211> 1426
<212> DNA
<213> Rattus norvegicus
<308> U16245
<400> 8158

ggcacgagg  accgcgcgc  gagccccgc  gacagacgc  cgccgctac  agcgccgcc  60
cgacggccg  cccgcaacc  tcccgctgc  accgggccc  caaggcacc  tgaaaaagg  120
ggtgtgctc  cttgccttc  tcaaggcgg  gttcgcaga  ttcctggcc  ccctcatct  180
cgtcttctt  ggcctgggc  cagcactca  gtggccctc  gctctgccc  ccattctgc  240
aatctcaat  gcctttggc  tggccatag  taccttagc  caagctctg  gacctgtga  300
tggtggcca  atcaatcca  ccattactc  ggccctctt  ataggaaac  agatctcgc  360
gctccgagc  gtcttctac  tggcagccc  gctggtggg  gccattgct  gggcaggca  420
cctgtactg  ctggcgcca  tcaatgccc  gggtaacct  gccgtcaat  cgctgaaca  480
caacacaac  cctggcaag  ccatggtgg  ggagttaat  ttgactttc  agctagccc  540
ctgcatctt  tcctccacc  actctcgcc  aaccagccc  gtgggctcc  cagccttat  600
cattggctt  tctgtcaca  tgggccatc  tgtggggat  tacttcacc  gctgttcca  660
gaacccagc  cgatctttc  gccctgcgg  ggtcatgaa  cggttcagc  cctctcact  720
ggtcttctg  gtagggcct  ttgtggggg  catgctggc  gccatcctc  atttctacc  780
gctcttccc  tcctctctg  gcctccatg  tcgcgtggc  gtcgtcaaa  gcacatatg  840
gccggagga  gactgggaa  atcatcgag  ggagaggaa  aagaccatc  agctgacgg  900
acactgact  gtgccggac  ggggccagt  cctcagccc  tggaccact  gagaaaagg  960
agacgaaga  tttgaagca  ccctcccca  catcctctc  gctggggaa  aggcattgg  1020
tccccatgc  gctgcacag  gacaggagc  gaagcccat  atgggacac  tgggtgtgg  1080
ccaagggct  gagtctgac  gggtcaggg  catagccgc  ttggaatca  gcagaatgt  1140
tgccacagc  cagacctca  agattcgtg  atgcggtgc  aagctcaca  gcggtccag  1200
accacacca  aaagggacg  cagcttgct  atctctccc  acccagtat  tcaagtgcc  1260
aagccggcc  ccaggtgga  agaggggac  tttccccca  agctcttca  gagagggat  1320
gatggctca  ggagtgcta  tttatttat  tctggtcaa  gatgggggt  gggtggggc  1380
gctggtgtt  gagctggcg  ttcccaata  accacctat  ttcaaa  1426



<210> 8159
<211> 265
<212> PRT
<213> Rattus norvegicus
<308> P47864
<400> 8159

Met Lys Lys Glu Val Cys Ser Leu Ala Phe Phe Lys Ala Val Phe Ala 
  1               5                  10                  15
Glu Phe Leu Ala Thr Leu Ile Phe Val Phe Phe Gly Leu Gly Ser Ala 
             20                  25                  30
Leu Lys Trp Pro Ser Ala Leu Pro Thr Ile Leu Gln Ile Ser Ile Ala 
         35                  40                  45
Phe Gly Leu Ala Ile Gly Thr Leu Ala Gln Ala Leu Gly Pro Val Ser 
     50                  55                  60
Gly Gly His Ile Asn Pro Ala Ile Thr Leu Ala Leu Leu Ile Gly Asn 
 65                  70                  75                  80
Gln Ile Ser Leu Leu Arg Ala Val Phe Tyr Val Ala Ala Gln Leu Val 
                 85                  90                  95
Gly Ala Ile Ala Gly Ala Gly Ile Leu Tyr Trp Leu Ala Pro Leu Asn 
             100                105                110
Ala Arg Gly Asn Leu Ala Val Asn Ala Leu Asn Asn Asn Thr Thr Pro 
         115                120                125
Gly Lys Ala Met Val Val Glu Leu Ile Leu Thr Phe Gln Leu Ala Leu 
     130                135                140
Cys Ile Phe Ser Ser Thr Asp Ser Arg Arg Thr Ser Pro Val Gly Ser 
 145                150                155                160
Pro Ala Leu Ser Ile Gly Leu Ser Val Thr Leu Gly His Leu Val Gly 
                 165                170                175
Ile Tyr Phe Thr Gly Cys Ser Met Asn Pro Ala Arg Ser Phe Gly Pro 
             180                185                190
Ala Val Val Met Asn Arg Phe Ser Pro Ser His Trp Val Phe Trp Val 
         195                200                205
Gly Pro Ile Val Gly Ala Met Leu Ala Ala Ile Leu Tyr Phe Tyr Leu 
     210                215                220
Leu Phe Pro Ser Ser Leu Ser Leu His Asp Arg Val Ala Val Val Lys 
 225                230                235                240
Gly Thr Tyr Glu Pro Glu Glu Asp Trp Glu Asp His Arg Glu Glu Arg 
                 245                250                255
Lys Lys Thr Ile Glu Leu Thr Ala His 
             260                265



<210> 8160
<211> 1316
<212> DNA
<213> Homo sapiens
<308> NM_001651
<400> 8160

agctagacg  cccgaggtc  gagtgaagc  ccgggaccg  gccccgtct  ccagggagt  60
cggggcgca  ggcaccgag  agagcgcgg  agccaacct  ggcgcatca  gcgcagggc  120
cgggacgct  ggccggtct  caccgccgc  tgggtcacg  ggcccggac  ggccggcgg  180
tgccccggc  ggggggcgg  ggtcgcgcc  gggttgcgc  ggacgacgg  gagcggcgg  240
cccgcagcg  cctggagcc  cccaacccg  gccgcgctg  ccctcgagc  taggagccg  300
cccctgccc  cccgcgccg  ccccgcgcc  ggccgcccg  cccctatat  gcgcgcccc  360
gcagggccc  cgccaggcc  ccagcctcg  agtgggcgc  ggacagtgc  cggcgcccc  420
cagccaggc  cccgccccc  ccgcatcca  ctcctccgc  gcctgcgac  caacgggcg  480
cccccgccg  cagctcgcg  cgggccccc  cggccacca  gaagaagga  gtgtgctcc  540
tggccttcc  caaggccgt  ttcgcagag  tcttggcca  cctcatctt  gtcttcttt  600
gcctgggct  ggccctcaa  tggccgtcg  cgctgccta  catcctgca  atcgcgctg  660
cgtttggcc  ggccatagg  acgctggcc  aggccctgg  acccgtgag  ggcggccac  720
tcaaccccg  catcaccct  gccctcttg  tgggcaacc  gatctcgct  ctccgggct  780
tcttctacg  ggcggccca  ctggtgggc  ccattgccg  ggctggcat  ctctacggt  840
tggcaccgc  caatgcccg  ggcaatctg  ccgtcaacg  gctcaacaa  aacacaacg  900
agggccagg  catggtggt  gagctgatt  tgaccttcc  gctggcact  tgcatcttc  960
cctccactg  ctcccgccg  accagccct  tgggctccc  agccctgtc  attggcctg  1020
ctgtcaccc  gggccacct  gtcggaatc  acttcactg  ctgctccat  aacccagcc  1080
gctcttttg  ccctgcggt  gtcatgaat  ggttcagcc  cgctcactg  gttttctgg  1140
tagggccca  cgtgggggc  gtcctggct  ccatccttt  cttctacct  ctcttcccc  1200
actccctga  cctgagtga  cgtgtggcc  tcatcaaag  cacgtatga  cctgacgag  1260
actgggagg  gcagcggga  gagcggaag  agaccatgg  gctgaccac  cgctga  1316



<210> 8161
<211> 265
<212> PRT
<213> Homo sapiens
<308> NP_001642
<400> 8161

Met Lys Lys Glu Val Cys Ser Val Ala Phe Leu Lys Ala Val Phe Ala 
  1               5                  10                  15
Glu Phe Leu Ala Thr Leu Ile Phe Val Phe Phe Gly Leu Gly Ser Ala 
             20                  25                  30
Leu Lys Trp Pro Ser Ala Leu Pro Thr Ile Leu Gln Ile Ala Leu Ala 
         35                  40                  45
Phe Gly Leu Ala Ile Gly Thr Leu Ala Gln Ala Leu Gly Pro Val Ser 
     50                  55                  60
Gly Gly His Ile Asn Pro Ala Ile Thr Leu Ala Leu Leu Val Gly Asn 
 65                  70                  75                  80
Gln Ile Ser Leu Leu Arg Ala Phe Phe Tyr Val Ala Ala Gln Leu Val 
                 85                  90                  95
Gly Ala Ile Ala Gly Ala Gly Ile Leu Tyr Gly Val Ala Pro Leu Asn 
             100                105                110
Ala Arg Gly Asn Leu Ala Val Asn Ala Leu Asn Asn Asn Thr Thr Gln 
         115                120                125
Gly Gln Ala Met Val Val Glu Leu Ile Leu Thr Phe Gln Leu Ala Leu 
     130                135                140
Cys Ile Phe Ala Ser Thr Asp Ser Arg Arg Thr Ser Pro Val Gly Ser 
 145                150                155                160
Pro Ala Leu Ser Ile Gly Leu Ser Val Thr Leu Gly His Leu Val Gly 
                 165                170                175
Ile Tyr Phe Thr Gly Cys Ser Met Asn Pro Ala Arg Ser Phe Gly Pro 
             180                185                190
Ala Val Val Met Asn Arg Phe Ser Pro Ala His Trp Val Phe Trp Val 
         195                200                205
Gly Pro Ile Val Gly Ala Val Leu Ala Ala Ile Leu Tyr Phe Tyr Leu 
     210                215                220
Leu Phe Pro Asn Ser Leu Ser Leu Ser Glu Arg Val Ala Ile Ile Lys 
 225                230                235                240
Gly Thr Tyr Glu Pro Asp Glu Asp Trp Glu Glu Gln Arg Glu Glu Arg 
                 245                250                255
Lys Lys Thr Met Glu Leu Thr Thr Arg 
             260                265



<210> 8162
<211> 2696
<212> DNA
<213> Rattus norvegicus
<308> U16655
<400> 8162

gaagcagtc  agtgcaaag  agaaaagga  tcttctcat  ctcagtgga  agcattgtg  60
agctcggga  acgacgctc  cagacacag  attactatc  tacccacgg  gactctggc  120
ccagctggt  gagcagtgg  ggatggcat  tcagattca  aagctactg  ccactaatc  180
ggacctgct  ctgatgcaa  aaggaacga  gatgcgcaa  gtgaggacc  aaagctgga  240
gaagctaag  tacttcaga  ttcaggatg  cggcatgac  gtctggcat  ggcggcacc  300
tgaaagcat  tccaagccc  ctttttcaa  ctctgatgt  gagaggatc  gtaagggcc  360
ggattctga  ctgttgcgc  atctggtgg  agagttccc  ctggagcaa  gcttcacca  420
tgtctttaa  gggcgccgc  ccaacctgg  cctagtggc  aacagtgtt  aagaggccc  480
gacttggat  cgaggactc  agctgttgg  ggatctcgt  gccagaatg  actaccagg  540
gcagctgga  caaatgttg  gagaatggt  ccaacaagc  gacagaaac  aggacagcc  600
gatgagttt  agagaagct  aacggctgc  gcttctgat  aatgtggaa  tggatgaag  660
atatgcctt  agtcttttt  aggaagcag  tgtttccca  tctaatact  tggattcag  720
agaatttgt  cagttctat  aggccctga  taagcgcac  gagattgaa  aactatttg  780
gaacttttc  tctgacaaa  agaagctga  cttgctgga  tttgtagat  tccttagag  840
ggaacagaa  gaaagcgac  attcctctg  ccttgctct  aaactcatt  accgctatg  900
gccttctga  aatggcaga  tgctacgtg  gctgagcaa  gatggcttc  tcagctacc  960
ctgctcagc  gatggaaac  tcttcaacc  cgactgcct  cctatctat  aggatatga  1020
tcagcctct  agtcactac  acatcaact  ctctcacaa  acctaccta  tgggtgacc  1080
gttttgtgg  cagagcagc  ttgaaggat  catacgggc  ttgaaacgg  ggtgccgct  1140
tgtggaggt  gatacatgg  acggacctg  cggagagcc  gttgtttat  atgggcgta  1200
actgacctc  cgtatcctg  tcaaagatg  tttggcaac  ttagcacaa  atgccttcc  1260
gtcgtcaga  tacccactc  tcttatctc  ggataacca  tgcacttgg  aacagcaga  1320
gaccatggc  caccatctg  ttgcgatcc  gggagagca  ctgctgagt  ccaccctag  1380
ggaacaact  attgatata  tgccctcgc  agagcagct  cgggggaag  tcttggtaa  1440
aggaaagaa  ttgagaaca  ttgaggttg  tgagtctga  aaggaggaa  aagagctgg  1500
gaaagatga  gggtcagat  tggacccag  ctccgctga  cttgacatg  agtctcagc  1560
cgagtccca  gagcaggcc  ctgggaaca  gagcaagaa  aagaagaag  ttcttctcc  1620
gagttccac  accatccta  gcccagacc  atctgccct  gttgtctac  tgaggactg  1680
tcccttctg  agcttcact  actccaaag  aaactacca  atctacgac  tttcatcct  1740
ttctgagtc  aaggccaag  acctcatca  ggaggcagg  aatgagttt  tacagcaca  1800
tgccagaca  ctatgccgt  tatacccca  tggtctgag  acagattca  cgaactata  1860
cccccagga  cactggaat  ttggctgcc  aatggtggc  atgaacatg  agactgcag  1920
aagtgcaat  gacatctgt  atgggctct  ccgccagaa  gggggctct  gctatgtgc  1980
gaagccaga  ttcctgaga  atacccaga  ttccttcaa  cccatgaag  ccgttagtc  2040
ttataaagc  cagatcctt  tagtccagg  gatcagtgg  caaagactc  ccaaagtgg  2100
caaaaccaa  gagacaacc  ttgtggatc  actggtgag  gtagagctc  atggtgttc  2160
tgaagacac  aagcagcaa  agaccagct  tgtggagaa  aatggtatt  atccatact  2220
gggggagac  ttctatttc  agatccagg  gcctgaact  gctatgctg  gttttgtgg  2280
aaaggatta  agcaggaca  cccgaaata  ctttatagg  caatacacc  tgccttgga  2340
ctgcatgaa  catggctac  gacatgtat  cttgctctc  aaagacggc  ctagcctcc  2400
tccagcctc  atctttgtg  acacctgca  gcaagaaga  ctggatatg  atgagccct  2460
agaaacaca  ggagggtct  gaagcagga  aatctacag  tgcactctt  tccaaccta  2520
aacttcctc  gcatccaga  ccagccaaa  gatcagtgg  ggaccaagg  tcccaggtg  2580
aggttgagg  agaatcctg  cccagaact  tgactctag  gaacagtgc  cagccgagt  2640
cccactgga  tgctgctcc  tagctggtc  aaatagagc  tctctgtcc  acttga  2696



<210> 8163
<211> 772
<212> PRT
<213> Rattus norvegicus
<308> AAC52346
<400> 8163

Met Ala Ser Gln Ile Gln Lys Leu Leu Thr Thr Asn Gln Asp Leu Leu 
  1               5                  10                  15
Leu Met Gln Lys Gly Thr Met Met Arg Lys Val Arg Thr Lys Ser Trp 
             20                  25                  30
Lys Lys Leu Arg Tyr Phe Arg Leu Gln Asp Asp Gly Met Thr Val Trp 
         35                  40                  45
His Gly Arg His Leu Glu Ser Ile Ser Lys Pro Thr Phe Ser Ile Ser 
     50                  55                  60
Asp Val Glu Arg Ile Arg Lys Gly Gln Asp Ser Glu Leu Leu Arg Tyr 
 65                  70                  75                  80
Leu Val Glu Glu Phe Pro Leu Glu Gln Gly Phe Thr Ile Val Phe Asn 
                 85                  90                  95
Gly Arg Arg Pro Asn Leu Asp Leu Val Ala Asn Ser Val Glu Glu Ala 
             100                105                110
Gln Thr Trp Met Arg Gly Leu Gln Leu Leu Val Asp Leu Val Ala Arg 
         115                120                125
Met Asn Tyr Gln Glu Gln Leu Asp Gln Met Leu Arg Glu Trp Phe Gln 
     130                135                140
Gln Ala Asp Arg Asn Gln Asp Ser Arg Met Ser Phe Arg Glu Ala Gln 
 145                150                155                160
Arg Leu Leu Leu Leu Met Asn Val Glu Met Asp Glu Glu Tyr Ala Phe 
                 165                170                175
Ser Leu Phe Gln Glu Ala Asp Val Ser Gln Ser Asn Thr Leu Asp Ser 
             180                185                190
Glu Glu Phe Val Gln Phe Tyr Lys Ala Leu Thr Lys Arg Thr Glu Ile 
         195                200                205
Glu Glu Leu Phe Glu Asn Phe Ser Ser Asp Lys Gln Lys Leu Thr Leu 
     210                215                220
Leu Glu Phe Val Asp Phe Leu Arg Glu Glu Gln Lys Glu Ser Asp His 
 225                230                235                240
Ser Ser Asp Leu Ala Leu Lys Leu Ile Asp Arg Tyr Glu Pro Ser Glu 
                 245                250                255
Asn Gly Arg Leu Leu Arg Val Leu Ser Lys Asp Gly Phe Leu Ser Tyr 
             260                265                270
Leu Cys Ser Ala Asp Gly Asn Ile Phe Asn Pro Asp Cys Leu Pro Ile 
         275                280                285
Tyr Gln Asp Met Thr Gln Pro Leu Ser His Tyr Tyr Ile Asn Ser Ser 
     290                295                300
His Asn Thr Tyr Leu Leu Gly Asp Gln Phe Cys Gly Gln Ser Ser Val 
 305                310                315                320
Glu Gly Tyr Ile Arg Ala Leu Lys Arg Gly Cys Arg Cys Val Glu Val 
                 325                330                335
Asp Thr Trp Asp Gly Pro Asp Gly Glu Pro Val Val Tyr His Gly Arg 
             340                345                350
Thr Leu Thr Ser Arg Ile Leu Phe Lys Asp Val Leu Ala Thr Leu Ala 
         355                360                365
Gln Tyr Ala Phe Gln Ser Ser Asp Tyr Pro Leu Ile Leu Ser Leu Asp 
     370                375                380
Asn His Cys Thr Trp Glu Gln Gln Lys Thr Met Ala His His Leu Ile 
 385                390                395                400
Ala Ile Leu Gly Glu Gln Leu Leu Ser Thr Thr Leu Glu Glu Gln Leu 
                 405                410                415
Ile Asp Ile Met Pro Ser Pro Glu Gln Leu Arg Gly Lys Ile Leu Val 
             420                425                430
Lys Gly Lys Lys Leu Arg Thr Ile Glu Val Val Glu Ser Asp Lys Glu 
         435                440                445
Glu Glu Glu Leu Glu Lys Asp Glu Gly Ser Asp Leu Asp Pro Ala Ser 
     450                455                460
Ala Glu Leu Asp Met Gln Ser Gln Pro Glu Ser Gln Glu Gln Ala Ser 
 465                470                475                480
Gly Asn Lys Ser Lys Asn Lys Lys Lys Phe Leu Leu Gln Ser Ser Thr 
                 485                490                495
Thr Ile Leu Cys Pro Asp Leu Ser Ala Leu Val Val Tyr Leu Arg Thr 
             500                505                510
Ala Pro Phe Cys Ser Phe Thr His Ser Lys Glu Asn Tyr His Ile Tyr 
         515                520                525
Asp Ile Ser Ser Phe Ser Glu Ser Lys Ala Lys Asn Leu Ile Arg Glu 
     530                535                540
Ala Gly Asn Glu Phe Val Gln His Asn Ala Arg Gln Leu Cys Arg Val 
 545                550                555                560
Tyr Pro Ser Gly Leu Arg Thr Asp Ser Ser Asn Tyr Asn Pro Gln Glu 
                 565                570                575
His Trp Asn Val Gly Cys Gln Met Val Ala Met Asn Met Gln Thr Ala 
             580                585                590
Gly Ser Ala Met Asp Ile Cys Asp Gly Leu Phe Arg Gln Asn Gly Gly 
         595                600                605
Ser Gly Tyr Val Leu Lys Pro Glu Phe Leu Arg Asp Thr Gln Ser Ser 
     610                615                620
Phe Asn Pro Met Lys Pro Val Ser Leu Tyr Lys Ala Gln Ile Leu Val 
 625                630                635                640
Val Gln Val Ile Ser Gly Gln Arg Leu Pro Lys Val Asp Lys Thr Lys 
                 645                650                655
Glu Thr Thr Val Val Asp Pro Leu Val Arg Val Glu Leu Tyr Gly Val 
             660                665                670
Pro Glu Asp Thr Lys Gln Gln Glu Thr Ser Tyr Val Glu Asn Asn Gly 
         675                680                685
Ile Asn Pro Tyr Trp Gly Glu Thr Phe Tyr Phe Gln Ile Gln Val Pro 
     690                695                700
Glu Leu Ala Met Leu Arg Phe Val Val Lys Asp Tyr Ser Arg Thr Ser 
 705                710                715                720
Arg Asn Asn Phe Ile Gly Gln Tyr Thr Leu Pro Trp Thr Cys Met Lys 
                 725                730                735
His Gly Tyr Arg His Val Ser Leu Leu Ser Lys Asp Gly Thr Ser Leu 
             740                745                750
His Pro Ala Ser Ile Phe Val Tyr Thr Cys Met Gln Glu Asp Leu Asp 
         755                760                765
Met Asp Glu Pro 
     770



<210> 8164
<211> 3263
<212> DNA
<213> Homo sapiens
<308> AK023083
<400> 8164

gctgtagaa  aggggagga  acaagccag  gcaagggga  caaaagaga  aaggagcca  60
gctgggctt  ctgatccca  agcatcgca  agctcggga  gcacagctc  cagacacag  120
aaacacagg  ctgctattc  gctctcctg  ccacggtga  ctggtgcca  ctggtggaa  180
agtgggtga  ggcgtccct  ctgcaagac  agctgacca  tgatcagga  ttgctgctg  240
tgcaggaag  catgccgat  cgcaagtct  aatctctga  gtggagaca  tacgtaatg  300
ccatgattc  gagttgctg  gtagcctgg  agaggagct  cccctggag  agggcttca  360
cattgtctt  catggccgc  gctccaacc  ggacctgat  gccaacagt  ttgaggagg  420
ccagatatg  atgcgaggg  tccagctgt  ggtggatct  gtcaccagc  tggaccatc  480
ggagcgcct  gaccagtat  ggcaggatg  agtcagggt  ggggtgagg  atcacgcta  540
ccctgaagg  gccagatgc  acaggttta  gaaaggcag  agacacgtc  cagtctgga  600
ccctggaag  agaagaatt  gtacagttc  ataaggcat  gactaaacg  gctgaggtg  660
aggaactgt  tgaaagttt  tcagctgat  ggcagaagc  gactctgct  gaatttttg  720
atttcctcc  agaggagca  aaggagaga  actgcacct  tgagcttgc  ctggaactc  780
ttgaccgct  tgaaccttc  gacagtggc  aactgcggc  tgtgctgag  atggatggc  840
tcctcagct  cctctgctc  aaggatgga  acaccttca  cccagcctg  ctccccatc  900
atcaggata  gactcaacc  ctgaaccac  acttcatct  ctcttctca  aacacctac  960
tagtggggg  ccagctttg  ggccagagc  gcgtcgagg  atatatacg  gccctgaag  1020
gggggtgcc  ctgcgtgga  gtggatgta  gggatggac  tagcgggga  cctgtcgtt  1080
accacggac  caccctgac  tcccgcatc  tgttcaaag  tgtcgtggc  acagtagca  1140
agtatgcct  ccagacatc  gactaccca  tcatcttgt  cctggagac  cactgcagc  1200
gggagcagc  gcagaccat  gcccgtcat  tgactgaga  cctggggga  cagctgctg  1260
gcaccacct  ggatggggt  ctgcccact  agctgccct  gcctgagga  cttcggagg  1320
agatcctgg  gaaggggaa  aagttaaca  ttgaggaag  cctggaata  gaggaagag  1380
aagcagaac  tgagttgga  gagtcagaa  tggcgctgg  gtcccagtt  gagactgag  1440
ctgagcccc  ggagcagaa  cttcagaat  aggacaaaa  gaagaaatc  aagcccatc  1500
tgtgtccag  cctctcttc  ctggttatc  acttgaagt  tgtctcatt  cgcagcttc  1560
cacattcaa  ggagcacta  cacttctac  agatatcat  tttctctga  accaaggcc  1620
agcgcctca  caaggaggc  ggtcaggac  aaaatggag  gatggggag  gaagtggga  1680
ggataggtt  aggcctgat  gactggcag  taagtccca  gaaaaaaga  aaggtagct  1740
aggagagat  aaggagttc  gaaactcct  agagcagac  agggcagag  agttatgaa  1800
agtggctca  gggtctagg  gcaggaaag  tggtctgga  ggacagagt  gagaggcac  1860
gtgaaactt  ctggagcca  cttcagatg  tggagagaa  ggtgaagag  aggcagggt  1920
cttgggact  gggaagtgg  agattccac  ccacttcca  ctccctctc  atacccttt  1980
acaggcaat  agtttgtgc  gcacaatac  tggcagtta  gccgtgtgt  tcccagcgg  2040
ctgaggaca  actcttcca  ctacaaccc  caggaactc  ggaatgcag  ctgccagat  2100
gtggccatg  atatgcaga  tgcagggct  gaaatggac  tctgtgatg  gcatttccg  2160
cagaatggc  gctgtggct  tgtgctgaa  ccagacttc  tgcgtgata  ccagagttc  2220
ttccaccct  agaagccca  cagcccttt  aaagcccag  ctctcttaa  ccaggtgat  2280
agcggtcag  aactcccca  agtggacaa  accaaagag  ggtccattg  ggatccact  2340
gtgaaagtg  agatctttg  cgttcgtct  gacacagca  ggcaggaga  caactatgt  2400
gagaacaat  gttttaatc  atactgggg  cagacacta  gtttccggg  gctggtgcc  2460
gaacttgcc  tgctgcgtt  tgtggtaat  gattatgac  ggaaatccc  aaatgactt  2520
attggtcag  acaccctgc  ttggacctg  atgcaacaa  gttaccgcc  cattcacct  2580
ctgtccaaa  atggcatca  cctccgccc  gcttccatc  ttgtgtata  ctgcatcca  2640
gaaggcctg  agggggatg  gtcctgagg  gggcatttc  cgggaaggg  tggtatgct  2700
gctttagac  gggagaaac  tctggaagg  tgctcgaga  aacaaatgg  ggtggtgaa  2760
atcaagctt  ggattgtgc  ttcctaggc  caaaattac  tcattcttc  taacaagca  2820
tctgggacc  gattttcca  cttttttct  ttttcttcc  ttcctttgt  ttcataagc  2880
tttggtatc  ttcctgccc  tttcctttg  gtactctat  ctggagttc  cttcttcct  2940
ttgctgtag  ctcaatccc  taccgacat  tacaactaa  ctttcccat  aactctgtg  3000
gaaggcagg  tgcaactag  aattcagag  ggcttggaa  agagaaacc  aaagaagca  3060
catcccctc  atccccaac  tcctcaaag  ccaaagcca  gggaaggat  aatcaaggc  3120
caaggcttc  ccagcaaag  ttagggaaa  agacttgac  ccaggactg  actacgact  3180
ttaagagaa  actgcacag  actcaaagt  ccccactgg  ctgcttcct  cttagcccc  3240
ctggtataa  tacatctct  tcc  3263



<210> 8165
<211> 762
<212> PRT
<213> Homo sapiens
<308> NP_116115
<400> 8165

Met Ala Ser Leu Leu Gln Asp Gln Leu Thr Thr Asp Gln Asp Leu Leu 
  1               5                  10                  15
Leu Met Gln Glu Gly Met Pro Met Arg Lys Val Arg Ser Lys Ser Trp 
             20                  25                  30
Lys Lys Leu Arg Tyr Phe Arg Leu Gln Asn Asp Gly Met Thr Val Trp 
         35                  40                  45
His Ala Arg Gln Ala Arg Gly Ser Ala Lys Pro Ser Phe Ser Ile Ser 
     50                  55                  60
Asp Val Glu Thr Ile Arg Asn Gly His Asp Ser Glu Leu Leu Arg Ser 
 65                  70                  75                  80
Leu Ala Glu Glu Leu Pro Leu Glu Gln Gly Phe Thr Ile Val Phe His 
                 85                  90                  95
Gly Arg Arg Ser Asn Leu Asp Leu Met Ala Asn Ser Val Glu Glu Ala 
             100                105                110
Gln Ile Trp Met Arg Gly Leu Gln Leu Leu Val Asp Leu Val Thr Ser 
         115                120                125
Met Asp His Gln Glu Arg Leu Asp Gln Trp Leu Ser Asp Trp Phe Gln 
     130                135                140
Arg Gly Asp Lys Asn Gln Asp Gly Lys Met Ser Phe Gln Glu Val Gln 
 145                150                155                160
Arg Leu Leu His Leu Met Asn Val Glu Met Asp Gln Glu Tyr Ala Phe 
                 165                170                175
Ser Leu Phe Gln Ala Ala Asp Thr Ser Gln Ser Gly Thr Leu Glu Gly 
             180                185                190
Glu Glu Phe Val Gln Phe Tyr Lys Ala Leu Thr Lys Arg Ala Glu Val 
         195                200                205
Gln Glu Leu Phe Glu Ser Phe Ser Ala Asp Gly Gln Lys Leu Thr Leu 
     210                215                220
Leu Glu Phe Leu Asp Phe Leu Gln Glu Glu Gln Lys Glu Arg Asp Cys 
 225                230                235                240
Thr Ser Glu Leu Ala Leu Glu Leu Ile Asp Arg Tyr Glu Pro Ser Asp 
                 245                250                255
Ser Gly Lys Leu Arg His Val Leu Ser Met Asp Gly Phe Leu Ser Tyr 
             260                265                270
Leu Cys Ser Lys Asp Gly Asp Ile Phe Asn Pro Ala Cys Leu Pro Ile 
         275                280                285
Tyr Gln Asp Met Thr Gln Pro Leu Asn His Tyr Phe Ile Cys Ser Ser 
     290                295                300
His Asn Thr Tyr Leu Val Gly Asp Gln Leu Cys Gly Gln Ser Ser Val 
 305                310                315                320
Glu Gly Tyr Ile Arg Ala Leu Lys Arg Gly Cys Arg Cys Val Glu Val 
                 325                330                335
Asp Val Trp Asp Gly Pro Ser Gly Glu Pro Val Val Tyr His Gly His 
             340                345                350
Thr Leu Thr Ser Arg Ile Leu Phe Lys Asp Val Val Ala Thr Val Ala 
         355                360                365
Gln Tyr Ala Phe Gln Thr Ser Asp Tyr Pro Val Ile Leu Ser Leu Glu 
     370                375                380
Thr His Cys Ser Trp Glu Gln Gln Gln Thr Met Ala Arg His Leu Thr 
 385                390                395                400
Glu Ile Leu Gly Glu Gln Leu Leu Ser Thr Thr Leu Asp Gly Val Leu 
                 405                410                415
Pro Thr Gln Leu Pro Ser Pro Glu Glu Leu Arg Arg Lys Ile Leu Val 
             420                425                430
Lys Gly Lys Lys Leu Thr Leu Glu Glu Asp Leu Glu Tyr Glu Glu Glu 
         435                440                445
Glu Ala Glu Pro Glu Leu Glu Glu Ser Glu Leu Ala Leu Glu Ser Gln 
     450                455                460
Phe Glu Thr Glu Pro Glu Pro Gln Glu Gln Asn Leu Gln Asn Lys Asp 
 465                470                475                480
Lys Lys Lys Lys Ser Lys Pro Ile Leu Cys Pro Ala Leu Ser Ser Leu 
                 485                490                495
Val Ile Tyr Leu Lys Ser Val Ser Phe Arg Ser Phe Thr His Ser Lys 
             500                505                510
Glu His Tyr His Phe Tyr Glu Ile Ser Ser Phe Ser Glu Thr Lys Ala 
         515                520                525
Lys Arg Leu Ile Lys Glu Ala Gly Asn Glu Phe Val Gln His Asn Thr 
     530                535                540
Trp Gln Leu Ser Arg Val Tyr Pro Ser Gly Leu Arg Thr Asp Ser Ser 
 545                550                555                560
Asn Tyr Asn Pro Gln Glu Leu Trp Asn Ala Gly Cys Gln Met Val Ala 
                 565                570                575
Met Asn Met Gln Thr Ala Gly Leu Glu Met Asp Ile Cys Asp Gly His 
             580                585                590
Phe Arg Gln Asn Gly Gly Cys Gly Tyr Val Leu Lys Pro Asp Phe Leu 
         595                600                605
Arg Asp Ile Gln Ser Ser Phe His Pro Glu Lys Pro Ile Ser Pro Phe 
     610                615                620
Lys Ala Gln Thr Leu Leu Ile Gln Val Ile Ser Gly Gln Gln Leu Pro 
 625                630                635                640
Lys Val Asp Lys Thr Lys Glu Gly Ser Ile Val Asp Pro Leu Val Lys 
                 645                650                655
Val Gln Ile Phe Gly Val Arg Leu Asp Thr Ala Arg Gln Glu Thr Asn 
             660                665                670
Tyr Val Glu Asn Asn Gly Phe Asn Pro Tyr Trp Gly Gln Thr Leu Cys 
         675                680                685
Phe Arg Val Leu Val Pro Glu Leu Ala Met Leu Arg Phe Val Val Met 
     690                695                700
Asp Tyr Asp Trp Lys Ser Arg Asn Asp Phe Ile Gly Gln Tyr Thr Leu 
 705                710                715                720
Pro Trp Thr Cys Met Gln Gln Gly Tyr Arg His Ile His Leu Leu Ser 
                 725                730                735
Lys Asp Gly Ile Ser Leu Arg Pro Ala Ser Ile Phe Val Tyr Ile Cys 
             740                745                750
Ile Gln Glu Gly Leu Glu Gly Asp Glu Ser 
         755                760



<210> 8166
<211> 485
<212> DNA
<213> Rattus norvegicus
<308> U16686
<400> 8166

caggtctgg  cagaagagt  ctgtctctc  tgctctgct  tccgtgatt  ctctcaaag  60
tctgagacc  acagccatg  ggacgctca  tctgcttac  gcccttctc  tgctggccc  120
ccacaccca  gcaaaatct  cccaaggaa  cgctgagga  gctccagac  aggagcagc  180
ggtcatgga  gaccaggat  tttccatat  ctttggagg  gataaaggc  ctgctctcc  240
agatgcaga  gtgaaggca  gcgtgacct  ctattgcag  cgcacacgc  gtggtttta  300
agaacggct  tctggggcc  gtggttacc  tggccgcat  tacagactg  gctgccgct  360
agcactccg  ccaagaaga  tccatttgt  aaatgatct  agatcttga  cgagactgc  420
atttgtcag  tgttatgtc  ttgagtttc  tcttccttt  cactcaaat  aagttctta  480
acagc  485



<210> 8167
<211> 94
<212> PRT
<213> Rattus norvegicus
<308> Q62716
<400> 8167

Met Arg Thr Leu Thr Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu His 
  1               5                  10                  15
Thr Gln Ala Lys Ser Pro Gln Gly Thr Ala Glu Glu Ala Pro Asp Gln 
             20                  25                  30
Glu Gln Leu Val Met Glu Asp Gln Asp Ile Ser Ile Ser Phe Gly Gly 
         35                  40                  45
Asp Lys Gly Thr Ala Leu Gln Asp Ala Asp Val Lys Ala Gly Val Thr 
     50                  55                  60
Cys Tyr Cys Arg Arg Thr Arg Cys Gly Phe Arg Glu Arg Leu Ser Gly 
 65                  70                  75                  80
Ala Cys Gly Tyr Arg Gly Arg Ile Tyr Arg Leu Cys Cys Arg 
                 85                  90



<210> 8168
<211> 449
<212> DNA
<213> Homo sapiens
<308> NM_021010
<400> 8168

atatccact  ctgctctcc  tcctgcagg  gaccccagc  atgaggacc  tcgccatcc  60
tgctgccat  ctcctggtg  ccctgcagg  ccaggctga  tcactccag  aaagagctg  120
tgaggctac  acccagaag  agtctgggg  agacaacca  gaccttgct  tctcctttg  180
aggaaatgg  ctctctgct  ttagaacct  aggttctca  gcaagagcc  cctgctatt  240
ccgaaccgg  cgttgtgct  cccgtgagt  cctctccgg  gtgtgtgaa  tcagtggcc  300
cctctacag  ctctgctgt  gctgagctt  ctagataga  accaaagca  tgcaagatt  360
agttcaagg  cctgaaaaa  gaaaaacat  ttactctgt  taccttgtg  ctttctaaa  420
ttctctctc  aaaataaag  tcaagcatt  449



<210> 8169
<211> 94
<212> PRT
<213> Homo sapiens
<308> NP_066290
<400> 8169

Met Arg Thr Ile Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
  1               5                  10                  15
Ala Gln Ala Glu Ser Leu Gln Glu Arg Ala Asp Glu Ala Thr Thr Gln 
             20                  25                  30
Lys Gln Ser Gly Glu Asp Asn Gln Asp Leu Ala Ile Ser Phe Ala Gly 
         35                  40                  45
Asn Gly Leu Ser Ala Leu Arg Thr Ser Gly Ser Gln Ala Arg Ala Thr 
     50                  55                  60
Cys Tyr Cys Arg Thr Gly Arg Cys Ala Thr Arg Glu Ser Leu Ser Gly 
 65                  70                  75                  80
Val Cys Glu Ile Ser Gly Arg Leu Tyr Arg Leu Cys Cys Arg 
                 85                  90



<210> 8170
<211> 2157
<212> DNA
<213> Rattus norvegicus
<308> U17013
<400> 8170

ctgacacca  cccagcaac  gcttttact  cagcaggcc  aggcccagg  ccagctcct  60
gctgctgca  tgcagcaac  ctccgccag  caacagcac  gtgctgctg  ggccaccat  120
tcagcctcc  ctgccacac  catgacgca  atccccctg  ctcagccca  acagattgc  180
caggatctt  aacaattgc  acagcttca  cagcaaaat  tcaacttgc  acagttcgt  240
ttggtgcac  caaccacca  cttgcaacc  gcacagttt  tcatctctc  gacccccca  300
ggccagcag  gtctcctgc  agcgcaaaa  cttttaacg  aactacctc  gcaaagcca  360
gccaacctc  tacagccac  gccaagcat  accctcacg  cccagccta  caccccaac  420
cgcacaata  cagcaaccc  aattcagac  cttccacag  gccagacaa  accaaagcg  480
attgatact  ccagcttgg  ggagcccag  gaccttgag  agcttgagc  atttgccaa  540
acttttaaa  aaagacgaa  caaacttgg  ttcactcag  gtgatgttg  gcttgctat  600
gggaaatta  atggaaatg  cttcagcca  accaccatc  ctcgctttg  agccttgaa  660
ctcagcttt  agaacatgt  caagttaaa  cccctttta  agaagtggc  aaatgacgc  720
gagaacctc  catctgatt  tacagcatc  agcccaagt  ctttgaatt  tccagggtt  780
ggggctgag  gcttgaatc  taggaggaa  aaacgcacc  gcatagaga  caacatccg  840
gtggcctta  aaaagagtt  catggagaa  caaaagcct  cctcggaag  tatcacctt  900
attgctgaa  agctcaata  ggagaagga  gtgattcgt  tttggtttt  taaccgccg  960
cagaaggag  aaagaatca  cccgccaag  agtggtggg  ccagcagct  accaatcaa  1020
gcaattttc  ccagcccaa  ctcactggt  gcaaccact  caagccttg  gacaagcag  1080
acagcaact  ccctcacag  caaccctgt  ctcccctta  ccagtgctg  catgactaa  1140
ctttctctt  caggcacta  agactccac  tccaacaac  cggccaccg  gatttccac  1200
gcaccccct  cttcctcag  agtcacatc  ccctccttg  gtccctctc  ttctgcctc  1260
gcctccacc  ctgaggcct  tagtgccag  gagaccagc  caacacaga  cacctccac  1320
cctctcccc  cccctcttg  agccagcca  gtgatggtg  cagcctctg  cttacagac  1380
gcagccgcc  ctgctctcc  aggagctgc  cagttgcca  caaatgcca  tcttgctgc  1440
atggctgct  ctgcaggac  caatccagg  ctgatggca  cctcacagt  tgctgctgg  1500
ggtgcctta  tcagtctca  tccggggac  ctgggtggg  ctctcagcc  ggccctgat  1560
agcaacagt  cactggcaa  cattcaagc  cttgcttct  gtggctctc  tccaataac  1620
tctctggat  caactggga  cctggtatt  gccaatgca  gaggagccc  caacatcgt  1680
actgcccct  tgttcctga  ccctcagaa  ctctctctg  tcaccagca  cccagtaag  1740
ttggtttct  ccgctgcag  ctccacagg  aactccgca  ctacagcca  ccttcatgc  1800
tcctccacc  caactgagt  catccagaa  tctctgttc  cagtggcct  tgccagcgg  1860
gctgcctcc  ccaccacag  tgcctccaa  gcacagtga  ctggacgca  agctggggc  1920
ttcctcact  cagggtgat  ggctggcta  cagctggct  aaacatgac  cctgtcatt  1980
gcttcctcc  accatgttg  gaggatgag  aagacatgg  gagaagaaa  aaattacac  2040
taacaacaa  aaaaaagaa  ggagacagg  caacgtttg  ctaatttta  aataaaaac  2100
atgtctttt  aggattgct  catggattg  agaactttc  aaccaaaaa  tttaaaa  2157



<210> 8171
<211> 632
<212> PRT
<213> Rattus norvegicus
<308> AAA53185
<400> 8171

Leu Thr Pro Ala Gln Gln Gln Leu Leu Leu Gln Gln Ala Gln Ala Gln 
  1               5                  10                  15
Ala Gln Leu Leu Ala Ala Ala Val Gln Gln His Ser Ala Ser Gln Gln 
             20                  25                  30
His Ser Ala Ala Gly Ala Thr Ile Ser Ala Ser Ala Ala Thr Pro Met 
         35                  40                  45
Thr Gln Ile Pro Leu Ser Gln Pro Ile Gln Ile Ala Gln Asp Leu Gln 
     50                  55                  60
Gln Leu Gln Gln Leu Gln Gln Gln Asn Leu Asn Leu Gln Gln Phe Val 
 65                  70                  75                  80
Leu Val His Pro Thr Thr Asn Leu Gln Pro Ala Gln Phe Ile Ile Ser 
                 85                  90                  95
Gln Thr Pro Gln Gly Gln Gln Gly Leu Leu Gln Ala Gln Asn Leu Leu 
             100                105                110
Thr Gln Leu Pro Gln Gln Ser Gln Ala Asn Leu Leu Gln Pro Gln Pro 
         115                120                125
Ser Ile Thr Leu Thr Ser Gln Pro Thr Thr Pro Thr Arg Thr Ile Ala 
     130                135                140
Ala Thr Pro Ile Gln Thr Leu Pro Gln Ser Gln Thr Thr Pro Lys Arg 
 145                150                155                160
Ile Asp Thr Pro Ser Leu Glu Glu Pro Ser Asp Leu Glu Glu Leu Glu 
                 165                170                175
Gln Phe Ala Lys Thr Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr 
             180                185                190
Gln Gly Asp Val Gly Leu Ala Met Gly Lys Leu Tyr Gly Asn Asp Phe 
         195                200                205
Ser Gln Thr Thr Ile Ser Arg Phe Glu Ala Leu Asn Leu Ser Phe Lys 
     210                215                220
Asn Met Cys Lys Leu Lys Pro Leu Leu Glu Lys Trp Leu Asn Asp Ala 
 225                230                235                240
Glu Asn Leu Ser Ser Asp Ser Thr Ala Ser Ser Pro Ser Ala Leu Asn 
                 245                250                255
Ser Pro Gly Leu Gly Ala Glu Gly Leu Asn Arg Arg Arg Lys Lys Arg 
             260                265                270
Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Met 
         275                280                285
Glu Asn Gln Lys Pro Thr Ser Glu Asp Ile Thr Leu Ile Ala Glu Gln 
     290                295                300
Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
 305                310                315                320
Gln Lys Glu Lys Arg Ile Asn Pro Pro Ser Ser Gly Gly Thr Ser Ser 
                 325                330                335
Ser Pro Ile Lys Ala Ile Phe Pro Ser Pro Thr Ser Leu Val Ala Thr 
             340                345                350
Thr Pro Ser Leu Val Thr Ser Ser Thr Ala Thr Thr Leu Thr Val Asn 
         355                360                365
Pro Val Leu Pro Leu Thr Ser Ala Ala Met Thr Asn Leu Ser Leu Thr 
     370                375                380
Gly Thr Thr Asp Ser Thr Ser Asn Asn Thr Ala Thr Val Ile Ser Thr 
 385                390                395                400
Ala Pro Pro Ala Ser Ser Ala Val Thr Ser Pro Ser Leu Ser Pro Ser 
                 405                410                415
Pro Ser Ala Ser Ala Ser Thr Ser Glu Ala Ser Ser Ala Ser Glu Thr 
             420                425                430
Ser Thr Thr Gln Thr Thr Ser Thr Pro Leu Pro Ser Pro Leu Gly Ala 
         435                440                445
Ser Gln Val Met Val Thr Ala Ser Gly Leu Gln Thr Ala Ala Ala Ala 
     450                455                460
Ala Leu Gln Gly Ala Ala Gln Leu Pro Ala Asn Ala Ser Leu Ala Ala 
 465                470                475                480
Met Ala Ala Ala Ala Gly Leu Asn Pro Gly Leu Met Ala Pro Ser Gln 
                 485                490                495
Phe Ala Ala Gly Gly Ala Leu Leu Ser Leu Asn Pro Gly Thr Leu Gly 
             500                505                510
Gly Ala Leu Ser Pro Ala Leu Met Ser Asn Ser Thr Leu Ala Thr Ile 
         515                520                525
Gln Ala Leu Ala Ser Ser Gly Ser Leu Pro Ile Thr Ser Leu Asp Ala 
     530                535                540
Thr Gly Asn Leu Val Phe Ala Asn Ala Gly Gly Ala Pro Asn Ile Val 
 545                550                555                560
Thr Ala Pro Leu Phe Leu Asn Pro Gln Asn Leu Ser Leu Leu Thr Ser 
                 565                570                575
Asn Pro Val Ser Leu Val Ser Ala Ala Ala Ala Ser Thr Gly Asn Ser 
             580                585                590
Ala Pro Thr Ala Ser Leu His Ala Ser Ser Thr Ser Thr Glu Ser Ile 
         595                600                605
Gln Asn Ser Leu Phe Thr Val Ala Ser Ala Ser Gly Ala Ala Ser Thr 
     610                615                620
Thr Thr Ala Ala Ser Lys Ala Gln 
 625                630



<210> 8172
<211> 2584
<212> DNA
<213> Homo sapiens
<308> NM_002697
<400> 8172

gaggagcag  gagtcaaga  gagagttca  ccgcggcgg  agcagcagc  gactcaaga  60
tgaacaatc  gtcagaaac  agtaaacca  ctatggaga  tggagatgg  aacacaggc  120
cacaaacca  tggtctgga  tttcagaag  agcctgtgc  tgtaggagg  gcaatctca  180
cagcccagg  gcaggcttt  cttggacat  tccatcagg  ccaactcgc  ggaacaagt  240
tacaggctg  tgctcagtc  ttaaatgta  agtctaaat  taatgaaga  tcgggggat  300
cgcagcagc  aagccagcc  tcccagcag  cttcagtgc  ggcagccat  ccccagacc  360
agcttatgc  agctggagg  cagataact  ggcttactt  gacgcctgc  cagcaacag  420
tactactcc  gcaggcaca  gcacaggca  agctgctgg  tgctgcagt  cagcagcac  480
ccgccagcc  gcagcacag  gctgctgga  ccaccatct  cgcctctgc  gccacgccc  540
tgacgcaga  ccccctgtc  cagcccata  agatcgcac  ggatcttca  caactgcaa  600
agcttcaac  gcagaatct  aacctgcaa  agtttgtgt  ggtgcatcc  accaccaat  660
tgcagccag  gcagtttat  atctcacag  cgccccagg  ccagcaggg  ctcctgcaa  720
cgcaaaatc  tcaaacgca  ctacctcag  aaagccaag  caacctcct  cagtcgcag  780
caagcatca  cctcacctc  cagccagca  ccccaacac  cacaatagc  gcaacccca  840
ttcagacac  tccacagag  cagtcaaca  caaagcgaa  tgatactcc  agcttggag  900
agcccagtg  ccttgagga  cttgagcag  ttgccaaga  cttcaaaca  agacgaatc  960
aacttggat  cactcaggg  gatgttggg  tcgctatgg  gaaactata  ggaaatgac  1020
tcagccaaa  taccatctc  cgatttgaa  ccttgaacc  cagctttaa  aacatgtgc  1080
agttgaagc  acttttaga  aagtggcta  atgatgcag  gaacctctc  tctgattcg  1140
ccctctcca  cccaagtgc  ctgaattct  caggaattg  gggcttgag  cgtaggagg  1200
agaaacgca  cagcataga  accaacatc  gtgtggcct  agagaagag  ttcttggag  1260
atcaaaagc  tacctcgga  gagatcact  tgattgctg  tcagctcaa  atggaaaaa  1320
aggtgattc  tgtttggtt  tgtaaccgc  gccagaaag  aaaaagaat  aacccacca  1380
gcagtggtg  gaccagcag  tcacctatt  aagcaattt  ccccagccc  acttcactg  1440
tggcgacca  accaagcct  gtgactagc  gtgcagcaa  taccctcac  gtcagccct  1500
tcctccctc  gaccagtgc  gctgtgacg  atctttcag  tacaggcac  tcagacacc  1560
cctccaaca  cacagcaac  gtgatttcc  cagcgcctc  agcttcctc  gcagtcacg  1620
ccccctctc  gagtccctc  ccttctgcc  cagcctcca  ctccgaggc  tccagtgcc  1680
gtgagacca  cacaacaca  accacctcc  ctcctttgt  ctcccctct  gggaccagc  1740
aggtgatgg  gacagcatc  ggtttgcaa  cagcagcag  tgctgccct  caaggagct  1800
cacagttgc  agcaaatgc  agtcttgct  ccatggcag  tgctgcagg  ctaaaccca  1860
gcctgatgg  accctcaca  tttgcggct  gaggtgcct  actcagtct  aatccaggg  1920
ccctgagcg  tgctctcag  ccagctcta  tgagcaaca  tacactggc  actattcaa  1980
ctcttgctt  tggtggctc  cttccaata  catcacttg  tgcaactgg  aacctggta  2040
ttgccaatg  gggaggagc  cccaacatc  tgactgccc  tctgttcct  aaccctcag  2100
acctctctc  gctcaccag  aaccctgtt  gcttggtct  tgccgccgc  gcatctgca  2160
ggaactctg  acctgtagc  agccttcac  ccacctcca  ctctgctga  tccatccag  2220
actctctct  cacagtggc  tctgccagc  gggctgcgt  caccaccac  accgcctcc  2280
aggcacagt  agctgggca  agctgggct  ccagaagcc  ttttcactc  gcagtgtga  2340
tggactgcc  gccaggtta  taaactgaa  aatgtgatt  gcttcctct  gccgtgttg  2400
gagggcaaa  gagagaagg  agaaaaaaa  aaaaaaaac  acacacacc  atacacaat  2460
taccagaaa  ggaaggaag  atggagacg  aacatttgc  taatttgta  taaaacact  2520
tcttttcag  gttgcttca  gggttggag  actttctaa  caaaaatta  aaaaaaaaa  2580
aaaa  2584



<210> 8173
<211> 743
<212> PRT
<213> Homo sapiens
<308> P14859
<400> 8173

Met Asn Asn Pro Ser Glu Thr Ser Lys Pro Ser Met Glu Ser Gly Asp 
  1               5                  10                  15
Gly Asn Thr Gly Thr Gln Thr Asn Gly Leu Asp Phe Gln Lys Gln Pro 
             20                  25                  30
Val Pro Val Gly Gly Ala Ile Ser Thr Ala Gln Ala Gln Ala Phe Leu 
         35                  40                  45
Gly His Leu His Gln Val Gln Leu Ala Gly Thr Ser Leu Gln Ala Ala 
     50                  55                  60
Ala Gln Ser Leu Asn Val Gln Ser Lys Ser Asn Glu Glu Ser Gly Asp 
 65                  70                  75                  80
Ser Gln Gln Pro Ser Gln Pro Ser Gln Gln Pro Ser Val Gln Ala Ala 
                 85                  90                  95
Ile Pro Gln Thr Gln Leu Met Leu Ala Gly Gly Gln Ile Thr Gly Leu 
             100                105                110
Thr Leu Thr Pro Ala Gln Gln Gln Leu Leu Leu Gln Gln Ala Gln Ala 
         115                120                125
Gln Ala Gln Leu Leu Ala Ala Ala Val Gln Gln His Ser Ala Ser Gln 
     130                135                140
Gln His Ser Ala Ala Gly Ala Thr Ile Ser Ala Ser Ala Ala Thr Pro 
 145                150                155                160
Met Thr Gln Ile Pro Leu Ser Gln Pro Ile Gln Ile Ala Gln Asp Leu 
                 165                170                175
Gln Gln Leu Gln Gln Leu Gln Gln Gln Asn Leu Asn Leu Gln Gln Phe 
             180                185                190
Val Leu Val His Pro Thr Thr Asn Leu Gln Pro Ala Gln Phe Ile Ile 
         195                200                205
Ser Gln Thr Pro Gln Gly Gln Gln Gly Leu Leu Gln Ala Gln Asn Leu 
     210                215                220
Gln Thr Gln Leu Pro Gln Gln Ser Gln Ala Asn Leu Leu Gln Ser Gln 
 225                230                235                240
Pro Ser Ile Thr Leu Thr Ser Gln Pro Ala Thr Pro Thr Arg Thr Ile 
                 245                250                255
Ala Ala Thr Pro Ile Gln Thr Leu Pro Gln Ser Gln Ser Thr Pro Lys 
             260                265                270
Arg Ile Asp Thr Pro Ser Leu Glu Glu Pro Ser Asp Leu Glu Glu Leu 
         275                280                285
Glu Gln Phe Ala Lys Thr Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe 
     290                295                300
Thr Gln Gly Asp Val Gly Leu Ala Met Gly Lys Leu Tyr Gly Asn Asp 
 305                310                315                320
Phe Ser Gln Thr Thr Ile Ser Arg Phe Glu Ala Leu Asn Leu Ser Phe 
                 325                330                335
Lys Asn Met Cys Lys Leu Lys Pro Leu Leu Glu Lys Trp Leu Asn Asp 
             340                345                350
Ala Glu Asn Leu Ser Ser Asp Ser Ser Leu Ser Ser Pro Ser Ala Leu 
         355                360                365
Asn Ser Pro Gly Ile Glu Gly Leu Ser Arg Arg Arg Lys Lys Arg Thr 
     370                375                380
Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu Glu 
 385                390                395                400
Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln Leu 
                 405                410                415
Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln 
             420                425                430
Lys Glu Lys Arg Ile Asn Pro Pro Ser Ser Gly Gly Thr Ser Ser Ser 
         435                440                445
Pro Ile Lys Ala Ile Phe Pro Ser Pro Thr Ser Leu Val Ala Thr Thr 
     450                455                460
Pro Ser Leu Val Thr Ser Ser Ala Ala Thr Thr Leu Thr Val Ser Pro 
 465                470                475                480
Val Leu Pro Leu Thr Ser Ala Ala Val Thr Asn Leu Ser Val Thr Gly 
                 485                490                495
Thr Ser Asp Thr Thr Ser Asn Asn Thr Ala Thr Val Ile Ser Thr Ala 
             500                505                510
Pro Pro Ala Ser Ser Ala Val Thr Ser Pro Ser Leu Ser Pro Ser Pro 
         515                520                525
Ser Ala Ser Ala Ser Thr Ser Glu Ala Ser Ser Ala Ser Glu Thr Ser 
     530                535                540
Thr Thr Gln Thr Thr Ser Thr Pro Leu Ser Ser Pro Leu Gly Thr Ser 
 545                550                555                560
Gln Val Met Val Thr Ala Ser Gly Leu Gln Thr Ala Ala Ala Ala Ala 
                 565                570                575
Leu Gln Gly Ala Ala Gln Leu Pro Ala Asn Ala Ser Leu Ala Ala Met 
             580                585                590
Ala Ala Ala Ala Gly Leu Asn Pro Ser Leu Met Ala Pro Ser Gln Phe 
         595                600                605
Ala Ala Gly Gly Ala Leu Leu Ser Leu Asn Pro Gly Thr Leu Ser Gly 
     610                615                620
Ala Leu Ser Pro Ala Leu Met Ser Asn Ser Thr Leu Ala Thr Ile Gln 
 625                630                635                640
Ala Leu Ala Ser Gly Gly Ser Leu Pro Ile Thr Ser Leu Asp Ala Thr 
                 645                650                655
Gly Asn Leu Val Phe Ala Asn Ala Gly Gly Ala Pro Asn Ile Val Thr 
             660                665                670
Ala Pro Leu Phe Leu Asn Pro Gln Asn Leu Ser Leu Leu Thr Ser Asn 
         675                680                685
Pro Val Ser Leu Val Ser Ala Ala Ala Ala Ser Ala Gly Asn Ser Ala 
     690                695                700
Pro Val Ala Ser Leu His Ala Thr Ser Thr Ser Ala Glu Ser Ile Gln 
 705                710                715                720
Asn Ser Leu Phe Thr Val Ala Ser Ala Ser Gly Ala Ala Ser Thr Thr 
                 725                730                735
Thr Thr Ala Ser Lys Ala Gln 
             740



<210> 8174
<211> 2415
<212> DNA
<213> Rattus norvegicus
<308> U17253
<400> 8174

ggcacgagg  aagtcacac  agggccatc  ttattctct  ttacaatat  aacatgctg  60
tgtggggtg  gcgttctgt  tgccctcag  aggagcagg  agcgatcca  cgtttcatc  120
ctagcgctc  acaaatggt  cttgagttc  cacagcagt  aaaactctg  ccttctctt  180
acagggata  ggaggaagg  ctcgtgagt  acctcccct  atgatgatg  ggagagggg  240
gggaaggca  ccccactcc  ccctgcagt  gacctgcta  gtctagctg  tgcttctcc  300
gaaaacatc  gtccagggg  ttcttgacc  cagcagcca  tgagaaaac  catggcctt  360
tgtcaacgc  tccctcgtg  ctcagcatt  agatatatt  tctctacac  gcggccagg  420
cacttaaac  tgttcaaga  aatcctaat  tttagggaa  gcattttaa  cgcacgccc  480
ccacgtccc  gcccccctc  atgggcgcg  gggcgtccc  gccgccgca  ccgccgcag  540
agcccggca  agccgttgt  gcggatcgc  ccgcagccg  gggccgcgt  aagcccatc  600
acagtaatg  ccacagcct  acctaggac  ctgggagag  tgcagctgt  tcgaatatt  660
cagaaagct  atctgcttt  ttactttga  gcctttatc  aacaaggtg  tgatgatgt  720
cagcaactg  gcgaagctg  agaagaaga  tttttggaa  tcatggcac  ggtgggcat  780
gcaagcaag  cccttcatg  tagacggct  cagaaggct  tgagagatt  ggttacaaa  840
cctggcctt  tcaaccagc  attgacttc  cttcctgtc  gtagcatac  catctataa  900
ttaccagag  gatcaccaa  atggctggg  atatcctgc  atagttatg  aaggagtag  960
agtgcccga  agccacatt  aaaggtccc  aaatgcgct  ccaccacct  tgttcagag  1020
ttgggtcag  gcaagtcag  ggtgggaag  ctagcactg  agagtgtca  tgaatccag  1080
ctctggcaa  gacaccaca  cactgaaag  gagcatagt  tctccccag  agacctggg  1140
tccccagcc  ccccaaagg  aagcagtga  gccctggat  ctgccgccg  gctctctgt  1200
gccgagtgt  tggagcgga  ggcccccac  ctgcccaaa  gtgacttga  tgaagtgaa  1260
gagctgctg  agaacaata  gaagttggc  aaaatgatt  gtcacatct  cgagatgag  1320
gacgaggat  cacacaagg  ggaggagat  agaaagtac  gcgccatct  tgggcgatt  1380
gactccaaa  gaaaggatg  taaacacct  acattgcat  agctcacgg  taacgaggc  1440
gctgctcag  tgtgtgtga  ggacaatgc  ctgctgacg  gaagagatg  gcttttcgc  1500
ctggccagg  aggtttctc  agaagttac  tacaaatac  cttacagga  caccaggtt  1560
aaatgtggt  aaagagatg  attgtctcc  aagagaatt  aaatggagg  tggatttcc  1620
gacttccag  aatctgtgc  aacactctt  cagcaggcc  gagccaaaa  tgaagagct  1680
gcaggtctc  gttcacagg  tgagaaggg  atggcaaag  aaatggagc  cctgtgtgc  1740
caggccggc  atgagaggc  gcagcagga  aggagactc  tggccgggc  ctacaggca  1800
agctctgga  agcagagcc  tgatggcgg  cttccttct  atggctccg  tggacaagg  1860
gaaaggcct  tgaatctcc  aattcctag  gtgcagaac  gacagcccc  tcattttgt  1920
gtggatggg  agctcagta  actttactc  aacgaggtg  agtcccact  atcagagag  1980
cttgggatt  taaaagact  tcctcactc  gcattcacc  tggaaaaga  agttattaa  2040
acagagccc  aagactcaa  atagctgag  ttctccccc  gctctctgg  aatgacacc  2100
gatccgagg  tatgctcca  cgtagatta  gccttaata  ccagtgttg  ctcattcag  2160
tcccagacc  tagccaaag  gtaagaact  acacagtcg  ctgtgggca  caggacaaa  2220
caacagcca  agaagaggg  accgagata  cactgcaaa  taacgggca  cgaccggtt  2280
ccttcctgt  taagttgct  gtgtggaaa  gctcaatac  gtaggcatt  actatttaa  2340
aatgtacaa  gtgtctgta  tttatagaa  caaatctag  tgttgatac  ttgcagtct  2400
atagacgtg  atccc  2415



<210> 8175
<211> 485
<212> PRT
<213> Rattus norvegicus
<308> Q62722
<400> 8175

Met Ala Thr Ala Leu Pro Arg Thr Leu Gly Glu Leu Gln Leu Tyr Arg 
  1               5                  10                  15
Ile Leu Gln Lys Ala Asn Leu Leu Ser Tyr Phe Asp Ala Phe Ile Gln 
             20                  25                  30
Gln Gly Gly Asp Asp Val Gln Gln Leu Cys Glu Ala Gly Glu Glu Glu 
         35                  40                  45
Phe Leu Glu Ile Met Ala Leu Val Gly Met Ala Ser Lys Pro Leu His 
     50                  55                  60
Val Arg Arg Leu Gln Lys Ala Leu Arg Asp Trp Val Thr Asn Pro Gly 
 65                  70                  75                  80
Leu Phe Asn Gln Pro Leu Thr Ser Leu Pro Val Ser Ser Ile Pro Ile 
                 85                  90                  95
Tyr Lys Leu Pro Glu Gly Ser Pro Thr Trp Leu Gly Ile Ser Cys Asn 
             100                105                110
Ser Tyr Glu Arg Ser Ser Ser Ala Arg Glu Pro His Leu Lys Val Pro 
         115                120                125
Lys Cys Ala Ala Thr Thr Cys Val Gln Ser Leu Gly Gln Gly Lys Ser 
     130                135                140
Glu Val Gly Ser Leu Ala Leu Gln Ser Val Ser Glu Ser Arg Leu Trp 
 145                150                155                160
Gln Gly His His Thr Thr Glu Ser Glu His Ser Leu Ser Pro Ala Asp 
                 165                170                175
Leu Gly Ser Pro Ala Ser Pro Lys Glu Ser Ser Glu Ala Leu Asp Ala 
             180                185                190
Ala Ala Ala Leu Ser Val Ala Glu Cys Val Glu Arg Met Ala Pro Thr 
         195                200                205
Leu Pro Lys Ser Asp Leu Asn Glu Val Lys Glu Leu Leu Lys Asn Asn 
     210                215                220
Lys Lys Leu Ala Lys Met Ile Gly His Ile Phe Glu Met Ser Asp Glu 
 225                230                235                240
Asp Pro His Lys Glu Glu Glu Ile Arg Lys Tyr Ser Ala Ile Tyr Gly 
                 245                250                255
Arg Phe Asp Ser Lys Arg Lys Asp Gly Lys His Leu Thr Leu His Glu 
             260                265                270
Leu Thr Val Asn Glu Ala Ala Ala Gln Leu Cys Val Lys Asp Asn Ala 
         275                280                285
Leu Leu Thr Arg Arg Asp Glu Leu Phe Ala Leu Ala Arg Gln Val Ser 
     290                295                300
Arg Glu Val Thr Tyr Lys Tyr Thr Tyr Arg Thr Thr Arg Leu Lys Cys 
 305                310                315                320
Gly Glu Arg Asp Glu Leu Ser Pro Lys Arg Ile Lys Met Glu Asp Gly 
                 325                330                335
Phe Pro Asp Phe Gln Glu Ser Val Pro Thr Leu Phe Gln Gln Ala Arg 
             340                345                350
Ala Lys Ser Glu Glu Leu Ala Gly Leu Ser Ser Gln Ala Glu Lys Gly 
         355                360                365
Met Ala Lys Gln Met Glu Leu Leu Cys Ala Gln Ala Gly Tyr Glu Arg 
     370                375                380
Leu Gln Gln Glu Arg Arg Leu Met Ala Gly Leu Tyr Arg Gln Ser Ser 
 385                390                395                400
Gly Glu Gln Ser Pro Asp Gly Gly Leu Pro Ser Asp Gly Ser Asp Gly 
                 405                410                415
Gln Gly Glu Arg Pro Leu Asn Leu Arg Ile Pro Ser Val Gln Asn Arg 
             420                425                430
Gln Pro His His Phe Val Val Asp Gly Glu Leu Ser Arg Leu Tyr Ser 
         435                440                445
Asn Glu Val Lys Ser His Ser Ser Glu Ser Leu Gly Ile Leu Lys Asp 
     450                455                460
Tyr Pro His Ser Ala Phe Thr Leu Glu Lys Lys Val Ile Lys Thr Glu 
 465                470                475                480
Pro Glu Asp Ser Arg 
                 485



<210> 8176
<211> 1476
<212> DNA
<213> Homo sapiens
<308> AF045452
<400> 8176

gttaaaccc  tccagagta  tggctgcgg  cttacccag  accctgggg  agttgcagc  60
gtatagaat  ttacaaaaa  ccaatctac  ttcttattt  gatgccttt  tccaacaag  120
tggtgatga  gtccagcaa  tctgtgaag  aggagaaga  gagtttttg  aaatcatgg  180
actcgtggg  atggctagc  agccccttc  tgttagaag  ctgcagaag  ctttgagag  240
ctgggtcac  aaccctggg  ttttcaatc  gccactgac  tcccttcct  tcagtagca  300
acccatcta  aaattacca  agggatcac  aacatggct  ggaatatcc  gcagtagtt  360
tgaaaggag  agcaatgcc  gggaacctc  tttaaaaat  cccaaatgt  ctgccacca  420
ctgtgtgca  agcttggga  aggggaagt  agatgtggt  gggagccta  cactgcaga  480
tgttggtga  tccagactc  ggcaaggcc  ccatgccac  gagagcgag  acagcctct  540
cccagcaga  ctgggctcc  ccgcgtccc  aaaggagag  agtgaggcg  tggatgctg  600
tgctgcgct  tctgtggct  agtgtgtgg  gcggatggc  cccacactg  caaaaagtg  660
cttgaatga  gtgaaagag  tgctaaaaa  caacaagaa  ttggccaaa  tgattggtc  720
catctttga  atgaacgat  atgatccac  caaagagga  gaaattcgg  aatacagtg  780
aatatatgg  agatttgac  caaagagga  ggatgggaa  catctcaca  ttcatgagc  840
cactgttaa  gaagcggct  ctcaactct  tgtgaagga  aatgccctg  tgacaagaa  900
agatgagct  tttgccttg  ctcgacaga  ttctcgaga  gtcacctat  aatatactt  960
cagaaccac  aagtcaaaa  gtggagaaa  agatgaatt  tccccaaag  gaattaaag  1020
ggagcagca  cctgaaaag  tgatggcaa  gcagatgga  ttcctttgc  accaagctg  1080
ctatgagag  ctgcagcat  ccgagagga  gttgtctgc  gggctttac  ggcagagct  1140
agaagagca  agtcctaac  gcttgactt  cgataactc  gatggacaa  gagaaagac  1200
tttgaatct  cgaatgcct  atttacaga  cagacaacc  catcatttt  tggtggatg  1260
ggagctgag  agactttac  ccagtgagg  aaagtccca  tcatcagag  gccttggga  1320
tttaaaaga  taccctcat  cagctttta  cttagaaaa  aaagtcatc  aaacagagc  1380
tgaagattc  agatagctg  gatttctct  accgttctc  ggaaatggc  tcagattta  1440
ggataatac  ccatcatag  aataagcct  aataac  1476



<210> 8177
<211> 486
<212> PRT
<213> Homo sapiens
<308> Q13506
<400> 8177

Met Ala Ala Ala Leu Pro Arg Thr Leu Gly Glu Leu Gln Leu Tyr Arg 
  1               5                  10                  15
Ile Leu Gln Lys Ala Asn Leu Leu Ser Tyr Phe Asp Ala Phe Ile Gln 
             20                  25                  30
Gln Gly Gly Asp Asp Val Gln Gln Leu Cys Glu Ala Gly Glu Glu Glu 
         35                  40                  45
Phe Leu Glu Ile Met Ala Leu Val Gly Met Ala Ser Lys Pro Leu His 
     50                  55                  60
Val Arg Arg Leu Gln Lys Ala Leu Arg Asp Trp Val Thr Asn Pro Gly 
 65                  70                  75                  80
Leu Phe Asn Gln Pro Leu Thr Ser Leu Pro Val Ser Ser Ile Pro Ile 
                 85                  90                  95
Tyr Lys Leu Pro Glu Gly Ser Pro Thr Trp Leu Gly Ile Ser Cys Ser 
             100                105                110
Ser Tyr Glu Arg Ser Ser Asn Ala Arg Glu Pro His Leu Lys Ile Pro 
         115                120                125
Asn Cys Ala Ala Thr Thr Cys Val Gln Ser Leu Gly Gln Gly Lys Ser 
     130                135                140
Asp Val Val Gly Ser Leu Ala Leu Gln Ser Val Gly Glu Ser Arg Leu 
 145                150                155                160
Trp Gln Gly His His Ala Thr Glu Ser Glu His Ser Leu Ser Pro Ala 
                 165                170                175
Asp Leu Gly Ser Pro Ala Ser Pro Lys Glu Ser Ser Glu Ala Leu Asp 
             180                185                190
Ala Ala Ala Ala Leu Ser Val Ala Glu Cys Val Glu Arg Met Ala Pro 
         195                200                205
Thr Leu Pro Lys Ser Asp Leu Asn Glu Val Lys Glu Leu Leu Lys Thr 
     210                215                220
Asn Lys Lys Leu Ala Lys Met Ile Gly His Ile Phe Glu Met Asn Asp 
 225                230                235                240
Asp Asp Pro His Lys Glu Glu Glu Ile Arg Lys Tyr Ser Ala Ile Tyr 
                 245                250                255
Gly Arg Phe Asp Ser Lys Arg Lys Asp Gly Lys His Leu Thr Leu His 
             260                265                270
Glu Leu Thr Val Asn Glu Ala Ala Ala Gln Leu Cys Val Lys Asp Asn 
         275                280                285
Ala Leu Leu Thr Arg Arg Asp Glu Leu Phe Ala Leu Ala Arg Gln Ile 
     290                295                300
Ser Arg Glu Val Thr Tyr Lys Tyr Thr Tyr Arg Thr Thr Lys Ser Lys 
 305                310                315                320
Cys Gly Glu Arg Asp Glu Leu Ser Pro Lys Arg Ile Lys Val Glu Asp 
                 325                330                335
Gly Phe Pro Asp Phe Gln Asp Ser Val Gln Thr Leu Phe Gln Gln Ala 
             340                345                350
Arg Ala Lys Ser Glu Glu Leu Ala Ala Leu Ser Ser Gln Pro Glu Lys 
         355                360                365
Val Met Ala Lys Gln Met Glu Phe Leu Cys Asn Gln Ala Gly Tyr Glu 
     370                375                380
Arg Leu Gln His Ala Glu Arg Arg Leu Ser Ala Gly Leu Tyr Arg Gln 
 385                390                395                400
Ser Ser Glu Glu His Ser Pro Asn Gly Leu Thr Ser Asp Asn Ser Asp 
                 405                410                415
Gly Gln Gly Glu Arg Pro Leu Asn Leu Arg Met Pro Asn Leu Gln Asn 
             420                425                430
Arg Gln Pro His His Phe Val Val Asp Gly Glu Leu Ser Arg Leu Tyr 
         435                440                445
Pro Ser Glu Ala Lys Ser His Ser Ser Glu Ser Leu Gly Ile Leu Lys 
     450                455                460
Asp Tyr Pro His Ser Ala Phe Thr Leu Glu Lys Lys Val Ile Lys Thr 
 465                470                475                480
Glu Pro Glu Asp Ser Arg 
                 485



<210> 8178
<211> 2488
<212> DNA
<213> Rattus norvegicus
<308> U17254
<400> 8178

gcgaaagtt  gggtagtgt  cgagaagga  tgcagagcg  acgcggaac  agactgcga  60
tgggtcctg  gtcgctggt  ccggccacg  ggagcggga  ccggccgga  atgccctgt  120
tccaagctc  atatggaac  ccagcaacc  gcccaggac  gcgtgacca  ctgacaggt  180
accccctgg  ccttgagtt  agcaagccc  ccatggacc  ggccagccc  gagacggcg  240
ccaccgcac  tgccaccct  cccagtttc  gcaccttca  ggacggcgg  tacaccgga  300
agtttgaca  cttcctata  cagctgccg  ggacagccc  gccgtgctc  tcggcctcc  360
ccacatctt  ttcctcgtc  tcggccacc  ctcccgcgt  ggcttcctt  aagtttgag  420
actttcagg  gtatggctg  taccctggc  ccctgagcg  cccattaga  gagaccctg  480
cctccagtg  ctctgatta  tatggaagc  cctgctcag  cccgtcacc  cctacaccc  540
acttccagc  atcccagct  tccccttgg  atggttcat  tggccactt  tcccccagc  600
agacttatg  aggccttcg  gtatggact  agcagttgc  caaggcttc  gggcctccg  660
cacctccaa  cttcttctc  ttcagtcct  ccaccggtc  cagccccag  ctggcccag  720
gttccctga  gttgttccc  gcaccagcc  cccaccagc  aggggaggg  gagagctat  780
ccgtgccag  cgctttccc  ggcttggca  ccacctctc  gaactgtga  acttccggc  840
ttctggacg  acccgtaac  tccaccaag  cccgcagtg  gtcttcagg  ggcagtgag  900
gccgctgtg  tgtctgtgg  gacaacgct  cgtgccagc  ttatggggt  cgcacctgt  960
agggctgca  aggcttctt  aagcgcaca  tacagaaaa  tgccaagta  atctgcctg  1020
caaacaagg  ctgccctgt  gacaagagg  ggcggaacc  ctgccagtt  tgtcgcttc  1080
agaagtgcc  ggctgtggg  atggtgaag  aagttgtcc  gacagacag  ctaaagggg  1140
ggcggggcc  gctaccttc  aaacccaag  agcccccag  tgcctcccc  accaatctc  1200
tcacgtccc  cattcgagc  catttggac  ccgggccta  cactgccaa  ttggactat  1260
ccaagttcc  ggaactggt  ctgccccgc  ttggaaagg  agatgccgg  gacgtgcag  1320
aattttatg  cttgctctc  ggctccctg  acgtcatcc  gaagtgggc  gaaaagatc  1380
cgggcttca  tgagctttc  ccaggagac  aagacctgt  gctagagtc  gcctttctg  1440
agctcttta  cctccgcct  gcctaccga  ctaagcccg  tgaggggaa  ctcatcttc  1500
gctcaggcc  ggtgctaca  cggctgcag  gtgcccgcg  ctttggtga  tggatagac  1560
acattctag  cttctcacg  tccctgcac  gcttgggtg  tgatgttcc  gcctttgcc  1620
gcctgtctg  tctggtcct  atcactgat  gacatggcc  ccaggaccc  cggcgggtg  1680
aggagctgc  gaaccgcat  gctagctgt  tgaaggaac  catggccgc  gtggcagga  1740
acccacagc  ggccagctg  ctgtcacgt  tgctgggca  actgcctga  ctccggact  1800
tgtgcaccc  aggcctaca  cgcatcttt  gcctcaagc  ggaggactt  gtgccccct  1860
cacctatcg  ggacaagat  tttatggac  ccttgtctt  ctgaccctg  cccgaacac  1920
cgtgcacac  cacgtgcat  ttcttcttg  cacccacgt  cctttaagc  catagccca  1980
ggaccccca  accacccca  cccccagcc  gttttttga  ctaagactg  tgtatctcc  2040
cattccaga  gatggacag  gagagagag  gagctcaag  cctgggggg  agggtgtgt  2100
ttcacgggg  tgaccccac  atttctctt  tccctccca  ctcagacct  gccttccgc  2160
tgtttttgt  agataaacc  tttttaaca  ataccactc  gctgtatat  agctgacgc  2220
gctgtaaat  cagaaagga  gaggtcggg  tgggggttt  agaggaagg  tgggccccc  2280
aaccccgcc  gctgggcaa  cctctcgag  ctccaactt  agatctctt  cgctctcct  2340
ccatgtgta  atagctgtc  ctcaagaag  tgattgaca  attctgatt  atatttgtg  2400
atttttttc  tggatttat  ggatgtgac  ttttctgat  aatatattt  atatattaa  2460
taaaaacta  acatgtagc  gaaaaaaa  2488



<210> 8179
<211> 597
<212> PRT
<213> Rattus norvegicus
<308> P22829
<400> 8179

Met Pro Cys Ile Gln Ala Gln Tyr Gly Thr Pro Ala Thr Ser Pro Gly 
  1               5                  10                  15
Pro Arg Asp His Leu Thr Gly Asp Pro Leu Ala Leu Glu Phe Ser Lys 
             20                  25                  30
Pro Thr Met Asp Leu Ala Ser Pro Glu Thr Ala Pro Thr Ala Pro Ala 
         35                  40                  45
Thr Leu Pro Ser Phe Ser Thr Phe Met Asp Gly Gly Tyr Thr Gly Glu 
     50                  55                  60
Phe Asp Thr Phe Leu Tyr Gln Leu Pro Gly Thr Ala Gln Pro Cys Ser 
 65                  70                  75                  80
Ser Ala Ser Ser Thr Ser Ser Ser Ser Ser Ser Ala Thr Ser Pro Ala 
                 85                  90                  95
Ser Ala Ser Phe Lys Phe Glu Asp Phe Gln Val Tyr Gly Cys Tyr Pro 
             100                105                110
Gly Thr Leu Ser Gly Pro Leu Asp Glu Thr Leu Ser Ser Ser Gly Ser 
         115                120                125
Asp Tyr Tyr Gly Ser Pro Cys Ser Ala Pro Ser Pro Pro Thr Pro Asn 
     130                135                140
Phe Gln Pro Ser Gln Leu Ser Pro Trp Asp Gly Ser Phe Gly His Phe 
 145                150                155                160
Ser Pro Ser Gln Thr Tyr Glu Gly Leu Arg Val Trp Thr Glu Gln Leu 
                 165                170                175
Pro Lys Ala Ser Gly Pro Pro Pro Pro Pro Thr Phe Phe Ser Phe Ser 
             180                185                190
Pro Pro Thr Gly Pro Ser Pro Ser Leu Ala Gln Ser Ser Leu Lys Leu 
         195                200                205
Phe Pro Ala Pro Ala Thr His Gln Leu Gly Glu Gly Glu Ser Tyr Ser 
     210                215                220
Val Pro Ala Ala Phe Pro Gly Leu Ala Pro Thr Ser Pro Asn Cys Asp 
 225                230                235                240
Thr Ser Gly Ile Leu Asp Ala Pro Val Thr Ser Thr Lys Ala Arg Ser 
                 245                250                255
Gly Ser Ser Gly Gly Ser Glu Gly Arg Cys Ala Val Cys Gly Asp Asn 
             260                265                270
Ala Ser Cys Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly 
         275                280                285
Phe Phe Lys Arg Thr Val Gln Lys Ser Ala Lys Tyr Ile Cys Leu Ala 
     290                295                300
Asn Lys Asp Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Phe 
 305                310                315                320
Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val 
                 325                330                335
Arg Thr Asp Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro 
             340                345                350
Lys Gln Pro Pro Asp Ala Ser Pro Thr Asn Leu Leu Thr Ser Leu Ile 
         355                360                365
Arg Ala His Leu Asp Ser Gly Pro Asn Thr Ala Lys Leu Asp Tyr Ser 
     370                375                380
Lys Phe Gln Glu Leu Val Leu Pro Arg Phe Gly Lys Glu Asp Ala Gly 
 385                390                395                400
Asp Val Gln Gln Phe Tyr Asp Leu Leu Ser Gly Ser Leu Asp Val Ile 
                 405                410                415
Arg Lys Trp Ala Glu Lys Ile Pro Gly Phe Ile Glu Leu Ser Pro Gly 
             420                425                430
Asp Gln Asp Leu Leu Leu Glu Ser Ala Phe Leu Glu Leu Phe Ile Leu 
         435                440                445
Arg Leu Ala Tyr Arg Ser Lys Pro Gly Glu Gly Lys Leu Ile Phe Cys 
     450                455                460
Ser Gly Leu Val Leu His Arg Leu Gln Cys Ala Arg Gly Phe Gly Asp 
 465                470                475                480
Trp Ile Asp Asn Ile Leu Ala Phe Ser Arg Ser Leu His Ser Leu Gly 
                 485                490                495
Val Asp Val Pro Ala Phe Ala Cys Leu Ser Ala Leu Val Leu Ile Thr 
             500                505                510
Asp Arg His Gly Leu Gln Asp Pro Arg Arg Val Glu Glu Leu Gln Asn 
         515                520                525
Arg Ile Ala Ser Cys Leu Lys Glu His Met Ala Ala Val Ala Gly Asp 
     530                535                540
Pro Gln Pro Ala Ser Cys Leu Ser Arg Leu Leu Gly Lys Leu Pro Glu 
 545                550                555                560
Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Cys Leu Lys 
                 565                570                575
Leu Glu Asp Leu Val Pro Pro Pro Pro Ile Val Asp Lys Ile Phe Met 
             580                585                590
Asp Thr Leu Ser Phe 
         595



<210> 8180
<211> 2481
<212> DNA
<213> Homo sapiens
<308> D49728
<400> 8180

cgaacttgg  gggagtgca  agaagaact  cgggagcgc  cgcgggacc  gggaccagg  60
tgagactcg  ggcgccagt  cgggcaggg  cagcgggag  cggccggag  tgccctgta  120
ccaagccca  tatgggaca  cagcaccga  tccgggacc  cgtgaccac  tggcaagcg  180
ccccctgac  cctgagttc  tcaagccca  catggacct  gccagcccc  aggcagccc  240
cgctgcccc  actgccctg  ccagcttca  caccttcat  gacggctac  caggagagt  300
tgacacctt  ctctaccag  tgccaggaa  agtccagcc  tgctcctca  cctcctcct  360
ggcctcctc  acatcctcg  cctcagcca  ctcccctgc  tctgcttcc  tcaagttcg  420
ggacttcca  gtgtacggc  gctaccccg  ccccctgag  ggcccagtg  atgaggccc  480
gtcctccag  ggctctgac  actatggca  cccctgctc  gccccgtcg  cctccacgc  540
cagcttcca  ccgccccag  tctctccct  ggatggctc  ttcggccac  tctcgccca  600
ccagactta  gaaggcctg  gggcatgga  agagcagct  cccaaagcc  ctgggcccc  660
acagcctcc  gccttcttt  ccttcagtc  tcccaccgg  cccagcccc  gcctggccc  720
gagccccct  aagttgttc  cctcacagg  cacccacca  ctgggggag  gagagagct  780
ttccatgcc  acggccttc  caggtttgg  acccacttc  ccacacctt  agggctcgg  840
gatactgga  acacccgtg  cctcaacca  ggcccggag  ggggcccca  gtggaagtg  900
aggccgctg  gctgtgtgt  gggacaacg  ttcatgcca  cattatggt  tccgcacat  960
tgagggctg  aagggcttc  tcaagcgca  agtgcagaa  aacgccaag  acatctgcc  1020
ggctaacaa  gactgccct  tggacaaga  gcggcgaaa  cgctgccag  tctgccgct  1080
ccagaagtg  ctggcggtg  gcatggtga  ggaagttgt  cgaacagac  gcctgaagg  1140
gcggcgggg  cggctacct  caaaaccca  gcagccccc  gatgcctcc  ctgccaatc  1200
cctcacttc  ctggtccgt  cacacctgg  ctcagggcc  agcactgcc  aactggact  1260
ctccaagtt  caggagctg  tgctgcccc  ctttgggaa  gaagatgct  gggatgtac  1320
gcagttcta  gacctgctc  ccggttctc  ggaggtcat  cgcaagtgg  cggagaaga  1380
ccctggctt  gctgagctg  caccggctg  ccaggacct  ttgctggag  cggccttcc  1440
ggagctctt  atcctccgc  tggcgtaca  gtctaagcc  ggcgagggc  agctcatct  1500
ctgctcagg  ctggtgcta  accggctgc  gtgtgcccg  ggcttcggg  actggattg  1560
cagtatcct  gccttctca  ggtccctgc  cagcttgct  gtcgatgtc  ctgccttcg  1620
ctgcctctc  gcccttgtc  tcatcaccg  ccggcatgg  ctgcaggag  cgcggcggg  1680
ggaggagct  cagaaccgc  tcgccagct  cctgaagga  cacgtggca  ctgtggcgg  1740
cgagcccca  ccagccagc  gcctgtcac  tctgttggg  aaactgccc  agctgcgga  1800
cctgtgcac  cagggcctg  agcgcatct  ctacctcaa  ctggaggac  tggtgcccc  1860
tccacccat  attgacaag  tcttcatgg  cacgctgcc  ttctgaccc  tgcctgcct  1920
ggaacacgt  tgcacatgc  cactctctc  tatgccacc  catgtgcct  tagtccacg  1980
accccagag  acccccaag  ctgggctta  ctgcagaac  gagggacct  ctcacctgc  2040
caaagggga  gaagggagg  aggctcaag  cccttgggg  agggggatg  cttcatggg  2100
gtgacccac  atgtgttct  atccccccc  cctggccac  ggcctttat  ttttttgta  2160
gataaaccg  ttttaacac  tagcgccgt  ctgtaaata  gcccagtac  gctgtaaat  2220
caggaagaa  gagcttgag  tgggagcgg  ctgggagga  gggatgggc  ccggccttc  2280
tgggcagcc  ttccagcct  ctgctgggc  ctctcttcc  accctcctt  cacatgtac  2340
tgtacataa  ctgtcactc  aggaagaag  caaatgaca  attctgacc  tttatattt  2400
tgtattttc  aggatttat  gtatgtgac  tttctgatt  atatattta  tatattgaa  2460
aaaaaatag  catgtagtt  g  2481



<210> 8181
<211> 598
<212> PRT
<213> Homo sapiens
<308> P22736
<400> 8181

Met Pro Cys Ile Gln Ala Gln Tyr Gly Thr Pro Ala Pro Ser Pro Gly 
  1               5                  10                  15
Pro Arg Asp His Leu Ala Ser Asp Pro Leu Thr Pro Glu Phe Ile Lys 
             20                  25                  30
Pro Thr Met Asp Leu Ala Ser Pro Glu Ala Ala Pro Ala Ala Pro Thr 
         35                  40                  45
Ala Leu Pro Ser Phe Ser Thr Phe Met Asp Gly Tyr Thr Gly Glu Phe 
     50                  55                  60
Asp Thr Phe Leu Tyr Gln Leu Pro Gly Thr Val Gln Pro Cys Ser Ser 
 65                  70                  75                  80
Ala Ser Ser Ser Ala Ser Ser Thr Ser Ser Ser Ser Ala Thr Ser Pro 
                 85                  90                  95
Ala Ser Ala Ser Phe Lys Phe Glu Asp Phe Gln Val Tyr Gly Cys Tyr 
             100                105                110
Pro Gly Pro Leu Ser Gly Pro Val Asp Glu Ala Leu Ser Ser Ser Gly 
         115                120                125
Ser Asp Tyr Tyr Gly Ser Pro Cys Ser Ala Pro Ser Pro Ser Thr Pro 
     130                135                140
Ser Phe Gln Pro Pro Gln Leu Ser Pro Trp Asp Gly Ser Phe Gly His 
 145                150                155                160
Phe Ser Pro Ser Gln Thr Tyr Glu Gly Leu Arg Ala Trp Thr Glu Gln 
                 165                170                175
Leu Pro Lys Ala Ser Gly Pro Pro Gln Pro Pro Ala Phe Phe Ser Phe 
             180                185                190
Ser Pro Pro Thr Gly Pro Ser Pro Ser Leu Ala Gln Ser Pro Leu Lys 
         195                200                205
Leu Phe Pro Ser Gln Ala Thr His Gln Leu Gly Glu Gly Glu Ser Tyr 
     210                215                220
Ser Met Pro Thr Ala Phe Pro Gly Leu Ala Pro Thr Ser Pro His Leu 
 225                230                235                240
Glu Gly Ser Gly Ile Leu Asp Thr Pro Val Thr Ser Thr Lys Ala Arg 
                 245                250                255
Ser Gly Ala Pro Gly Gly Ser Glu Gly Arg Cys Ala Val Cys Gly Asp 
             260                265                270
Asn Ala Ser Cys Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys 
         275                280                285
Gly Phe Phe Lys Arg Thr Val Gln Lys Asn Ala Lys Tyr Ile Cys Leu 
     290                295                300
Ala Asn Lys Asp Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln 
 305                310                315                320
Phe Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val 
                 325                330                335
Val Arg Thr Asp Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys 
             340                345                350
Pro Lys Gln Pro Pro Asp Ala Ser Pro Ala Asn Leu Leu Thr Ser Leu 
         355                360                365
Val Arg Ala His Leu Asp Ser Gly Pro Ser Thr Ala Lys Leu Asp Tyr 
     370                375                380
Ser Lys Phe Gln Glu Leu Val Leu Pro His Phe Gly Lys Glu Asp Ala 
 385                390                395                400
Gly Asp Val Gln Gln Phe Tyr Asp Leu Leu Ser Gly Ser Leu Glu Val 
                 405                410                415
Ile Arg Lys Trp Ala Glu Lys Ile Pro Gly Phe Ala Glu Leu Ser Pro 
             420                425                430
Ala Asp Gln Asp Leu Leu Leu Glu Ser Ala Phe Leu Glu Leu Phe Ile 
         435                440                445
Leu Arg Leu Ala Tyr Arg Ser Lys Pro Gly Glu Gly Lys Leu Ile Phe 
     450                455                460
Cys Ser Gly Leu Val Leu His Arg Leu Gln Cys Ala Arg Gly Phe Gly 
 465                470                475                480
Asp Trp Ile Asp Ser Ile Leu Ala Phe Ser Arg Ser Leu His Ser Leu 
                 485                490                495
Leu Val Asp Val Pro Ala Phe Ala Cys Leu Ser Ala Leu Val Leu Ile 
             500                505                510
Thr Asp Arg His Gly Leu Gln Glu Pro Arg Arg Val Glu Glu Leu Gln 
         515                520                525
Asn Arg Ile Ala Ser Cys Leu Lys Glu His Val Ala Ala Val Ala Gly 
     530                535                540
Glu Pro Gln Pro Ala Ser Cys Leu Ser Arg Leu Leu Gly Lys Leu Pro 
 545                550                555                560
Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                 565                570                575
Lys Leu Glu Asp Leu Val Pro Pro Pro Pro Ile Ile Asp Lys Ile Phe 
             580                585                590
Met Asp Thr Leu Pro Phe 
         595



<210> 8182
<211> 2488
<212> DNA
<213> Rattus norvegicus
<308> U17254
<400> 8182

gcgaaagtt  gggtagtgt  cgagaagga  tgcagagcg  acgcggaac  agactgcga  60
tgggtcctg  gtcgctggt  ccggccacg  ggagcggga  ccggccgga  atgccctgt  120
tccaagctc  atatggaac  ccagcaacc  gcccaggac  gcgtgacca  ctgacaggt  180
accccctgg  ccttgagtt  agcaagccc  ccatggacc  ggccagccc  gagacggcg  240
ccaccgcac  tgccaccct  cccagtttc  gcaccttca  ggacggcgg  tacaccgga  300
agtttgaca  cttcctata  cagctgccg  ggacagccc  gccgtgctc  tcggcctcc  360
ccacatctt  ttcctcgtc  tcggccacc  ctcccgcgt  ggcttcctt  aagtttgag  420
actttcagg  gtatggctg  taccctggc  ccctgagcg  cccattaga  gagaccctg  480
cctccagtg  ctctgatta  tatggaagc  cctgctcag  cccgtcacc  cctacaccc  540
acttccagc  atcccagct  tccccttgg  atggttcat  tggccactt  tcccccagc  600
agacttatg  aggccttcg  gtatggact  agcagttgc  caaggcttc  gggcctccg  660
cacctccaa  cttcttctc  ttcagtcct  ccaccggtc  cagccccag  ctggcccag  720
gttccctga  gttgttccc  gcaccagcc  cccaccagc  aggggaggg  gagagctat  780
ccgtgccag  cgctttccc  ggcttggca  ccacctctc  gaactgtga  acttccggc  840
ttctggacg  acccgtaac  tccaccaag  cccgcagtg  gtcttcagg  ggcagtgag  900
gccgctgtg  tgtctgtgg  gacaacgct  cgtgccagc  ttatggggt  cgcacctgt  960
agggctgca  aggcttctt  aagcgcaca  tacagaaaa  tgccaagta  atctgcctg  1020
caaacaagg  ctgccctgt  gacaagagg  ggcggaacc  ctgccagtt  tgtcgcttc  1080
agaagtgcc  ggctgtggg  atggtgaag  aagttgtcc  gacagacag  ctaaagggg  1140
ggcggggcc  gctaccttc  aaacccaag  agcccccag  tgcctcccc  accaatctc  1200
tcacgtccc  cattcgagc  catttggac  ccgggccta  cactgccaa  ttggactat  1260
ccaagttcc  ggaactggt  ctgccccgc  ttggaaagg  agatgccgg  gacgtgcag  1320
aattttatg  cttgctctc  ggctccctg  acgtcatcc  gaagtgggc  gaaaagatc  1380
cgggcttca  tgagctttc  ccaggagac  aagacctgt  gctagagtc  gcctttctg  1440
agctcttta  cctccgcct  gcctaccga  ctaagcccg  tgaggggaa  ctcatcttc  1500
gctcaggcc  ggtgctaca  cggctgcag  gtgcccgcg  ctttggtga  tggatagac  1560
acattctag  cttctcacg  tccctgcac  gcttgggtg  tgatgttcc  gcctttgcc  1620
gcctgtctg  tctggtcct  atcactgat  gacatggcc  ccaggaccc  cggcgggtg  1680
aggagctgc  gaaccgcat  gctagctgt  tgaaggaac  catggccgc  gtggcagga  1740
acccacagc  ggccagctg  ctgtcacgt  tgctgggca  actgcctga  ctccggact  1800
tgtgcaccc  aggcctaca  cgcatcttt  gcctcaagc  ggaggactt  gtgccccct  1860
cacctatcg  ggacaagat  tttatggac  ccttgtctt  ctgaccctg  cccgaacac  1920
cgtgcacac  cacgtgcat  ttcttcttg  cacccacgt  cctttaagc  catagccca  1980
ggaccccca  accacccca  cccccagcc  gttttttga  ctaagactg  tgtatctcc  2040
cattccaga  gatggacag  gagagagag  gagctcaag  cctgggggg  agggtgtgt  2100
ttcacgggg  tgaccccac  atttctctt  tccctccca  ctcagacct  gccttccgc  2160
tgtttttgt  agataaacc  tttttaaca  ataccactc  gctgtatat  agctgacgc  2220
gctgtaaat  cagaaagga  gaggtcggg  tgggggttt  agaggaagg  tgggccccc  2280
aaccccgcc  gctgggcaa  cctctcgag  ctccaactt  agatctctt  cgctctcct  2340
ccatgtgta  atagctgtc  ctcaagaag  tgattgaca  attctgatt  atatttgtg  2400
atttttttc  tggatttat  ggatgtgac  ttttctgat  aatatattt  atatattaa  2460
taaaaacta  acatgtagc  gaaaaaaa  2488



<210> 8183
<211> 597
<212> PRT
<213> Rattus norvegicus
<308> P22829
<400> 8183

Met Pro Cys Ile Gln Ala Gln Tyr Gly Thr Pro Ala Thr Ser Pro Gly 
  1               5                  10                  15
Pro Arg Asp His Leu Thr Gly Asp Pro Leu Ala Leu Glu Phe Ser Lys 
             20                  25                  30
Pro Thr Met Asp Leu Ala Ser Pro Glu Thr Ala Pro Thr Ala Pro Ala 
         35                  40                  45
Thr Leu Pro Ser Phe Ser Thr Phe Met Asp Gly Gly Tyr Thr Gly Glu 
     50                  55                  60
Phe Asp Thr Phe Leu Tyr Gln Leu Pro Gly Thr Ala Gln Pro Cys Ser 
 65                  70                  75                  80
Ser Ala Ser Ser Thr Ser Ser Ser Ser Ser Ser Ala Thr Ser Pro Ala 
                 85                  90                  95
Ser Ala Ser Phe Lys Phe Glu Asp Phe Gln Val Tyr Gly Cys Tyr Pro 
             100                105                110
Gly Thr Leu Ser Gly Pro Leu Asp Glu Thr Leu Ser Ser Ser Gly Ser 
         115                120                125
Asp Tyr Tyr Gly Ser Pro Cys Ser Ala Pro Ser Pro Pro Thr Pro Asn 
     130                135                140
Phe Gln Pro Ser Gln Leu Ser Pro Trp Asp Gly Ser Phe Gly His Phe 
 145                150                155                160
Ser Pro Ser Gln Thr Tyr Glu Gly Leu Arg Val Trp Thr Glu Gln Leu 
                 165                170                175
Pro Lys Ala Ser Gly Pro Pro Pro Pro Pro Thr Phe Phe Ser Phe Ser 
             180                185                190
Pro Pro Thr Gly Pro Ser Pro Ser Leu Ala Gln Ser Ser Leu Lys Leu 
         195                200                205
Phe Pro Ala Pro Ala Thr His Gln Leu Gly Glu Gly Glu Ser Tyr Ser 
     210                215                220
Val Pro Ala Ala Phe Pro Gly Leu Ala Pro Thr Ser Pro Asn Cys Asp 
 225                230                235                240
Thr Ser Gly Ile Leu Asp Ala Pro Val Thr Ser Thr Lys Ala Arg Ser 
                 245                250                255
Gly Ser Ser Gly Gly Ser Glu Gly Arg Cys Ala Val Cys Gly Asp Asn 
             260                265                270
Ala Ser Cys Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly 
         275                280                285
Phe Phe Lys Arg Thr Val Gln Lys Ser Ala Lys Tyr Ile Cys Leu Ala 
     290                295                300
Asn Lys Asp Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Phe 
 305                310                315                320
Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val 
                 325                330                335
Arg Thr Asp Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro 
             340                345                350
Lys Gln Pro Pro Asp Ala Ser Pro Thr Asn Leu Leu Thr Ser Leu Ile 
         355                360                365
Arg Ala His Leu Asp Ser Gly Pro Asn Thr Ala Lys Leu Asp Tyr Ser 
     370                375                380
Lys Phe Gln Glu Leu Val Leu Pro Arg Phe Gly Lys Glu Asp Ala Gly 
 385                390                395                400
Asp Val Gln Gln Phe Tyr Asp Leu Leu Ser Gly Ser Leu Asp Val Ile 
                 405                410                415
Arg Lys Trp Ala Glu Lys Ile Pro Gly Phe Ile Glu Leu Ser Pro Gly 
             420                425                430
Asp Gln Asp Leu Leu Leu Glu Ser Ala Phe Leu Glu Leu Phe Ile Leu 
         435                440                445
Arg Leu Ala Tyr Arg Ser Lys Pro Gly Glu Gly Lys Leu Ile Phe Cys 
     450                455                460
Ser Gly Leu Val Leu His Arg Leu Gln Cys Ala Arg Gly Phe Gly Asp 
 465                470                475                480
Trp Ile Asp Asn Ile Leu Ala Phe Ser Arg Ser Leu His Ser Leu Gly 
                 485                490                495
Val Asp Val Pro Ala Phe Ala Cys Leu Ser Ala Leu Val Leu Ile Thr 
             500                505                510
Asp Arg His Gly Leu Gln Asp Pro Arg Arg Val Glu Glu Leu Gln Asn 
         515                520                525
Arg Ile Ala Ser Cys Leu Lys Glu His Met Ala Ala Val Ala Gly Asp 
     530                535                540
Pro Gln Pro Ala Ser Cys Leu Ser Arg Leu Leu Gly Lys Leu Pro Glu 
 545                550                555                560
Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Cys Leu Lys 
                 565                570                575
Leu Glu Asp Leu Val Pro Pro Pro Pro Ile Val Asp Lys Ile Phe Met 
             580                585                590
Asp Thr Leu Ser Phe 
         595



<210> 8184
<211> 2481
<212> DNA
<213> Homo sapiens
<308> D49728
<400> 8184

cgaacttgg  gggagtgca  agaagaact  cgggagcgc  cgcgggacc  gggaccagg  60
tgagactcg  ggcgccagt  cgggcaggg  cagcgggag  cggccggag  tgccctgta  120
ccaagccca  tatgggaca  cagcaccga  tccgggacc  cgtgaccac  tggcaagcg  180
ccccctgac  cctgagttc  tcaagccca  catggacct  gccagcccc  aggcagccc  240
cgctgcccc  actgccctg  ccagcttca  caccttcat  gacggctac  caggagagt  300
tgacacctt  ctctaccag  tgccaggaa  agtccagcc  tgctcctca  cctcctcct  360
ggcctcctc  acatcctcg  cctcagcca  ctcccctgc  tctgcttcc  tcaagttcg  420
ggacttcca  gtgtacggc  gctaccccg  ccccctgag  ggcccagtg  atgaggccc  480
gtcctccag  ggctctgac  actatggca  cccctgctc  gccccgtcg  cctccacgc  540
cagcttcca  ccgccccag  tctctccct  ggatggctc  ttcggccac  tctcgccca  600
ccagactta  gaaggcctg  gggcatgga  agagcagct  cccaaagcc  ctgggcccc  660
acagcctcc  gccttcttt  ccttcagtc  tcccaccgg  cccagcccc  gcctggccc  720
gagccccct  aagttgttc  cctcacagg  cacccacca  ctgggggag  gagagagct  780
ttccatgcc  acggccttc  caggtttgg  acccacttc  ccacacctt  agggctcgg  840
gatactgga  acacccgtg  cctcaacca  ggcccggag  ggggcccca  gtggaagtg  900
aggccgctg  gctgtgtgt  gggacaacg  ttcatgcca  cattatggt  tccgcacat  960
tgagggctg  aagggcttc  tcaagcgca  agtgcagaa  aacgccaag  acatctgcc  1020
ggctaacaa  gactgccct  tggacaaga  gcggcgaaa  cgctgccag  tctgccgct  1080
ccagaagtg  ctggcggtg  gcatggtga  ggaagttgt  cgaacagac  gcctgaagg  1140
gcggcgggg  cggctacct  caaaaccca  gcagccccc  gatgcctcc  ctgccaatc  1200
cctcacttc  ctggtccgt  cacacctgg  ctcagggcc  agcactgcc  aactggact  1260
ctccaagtt  caggagctg  tgctgcccc  ctttgggaa  gaagatgct  gggatgtac  1320
gcagttcta  gacctgctc  ccggttctc  ggaggtcat  cgcaagtgg  cggagaaga  1380
ccctggctt  gctgagctg  caccggctg  ccaggacct  ttgctggag  cggccttcc  1440
ggagctctt  atcctccgc  tggcgtaca  gtctaagcc  ggcgagggc  agctcatct  1500
ctgctcagg  ctggtgcta  accggctgc  gtgtgcccg  ggcttcggg  actggattg  1560
cagtatcct  gccttctca  ggtccctgc  cagcttgct  gtcgatgtc  ctgccttcg  1620
ctgcctctc  gcccttgtc  tcatcaccg  ccggcatgg  ctgcaggag  cgcggcggg  1680
ggaggagct  cagaaccgc  tcgccagct  cctgaagga  cacgtggca  ctgtggcgg  1740
cgagcccca  ccagccagc  gcctgtcac  tctgttggg  aaactgccc  agctgcgga  1800
cctgtgcac  cagggcctg  agcgcatct  ctacctcaa  ctggaggac  tggtgcccc  1860
tccacccat  attgacaag  tcttcatgg  cacgctgcc  ttctgaccc  tgcctgcct  1920
ggaacacgt  tgcacatgc  cactctctc  tatgccacc  catgtgcct  tagtccacg  1980
accccagag  acccccaag  ctgggctta  ctgcagaac  gagggacct  ctcacctgc  2040
caaagggga  gaagggagg  aggctcaag  cccttgggg  agggggatg  cttcatggg  2100
gtgacccac  atgtgttct  atccccccc  cctggccac  ggcctttat  ttttttgta  2160
gataaaccg  ttttaacac  tagcgccgt  ctgtaaata  gcccagtac  gctgtaaat  2220
caggaagaa  gagcttgag  tgggagcgg  ctgggagga  gggatgggc  ccggccttc  2280
tgggcagcc  ttccagcct  ctgctgggc  ctctcttcc  accctcctt  cacatgtac  2340
tgtacataa  ctgtcactc  aggaagaag  caaatgaca  attctgacc  tttatattt  2400
tgtattttc  aggatttat  gtatgtgac  tttctgatt  atatattta  tatattgaa  2460
aaaaaatag  catgtagtt  g  2481



<210> 8185
<211> 598
<212> PRT
<213> Homo sapiens
<308> P22736
<400> 8185

Met Pro Cys Ile Gln Ala Gln Tyr Gly Thr Pro Ala Pro Ser Pro Gly 
  1               5                  10                  15
Pro Arg Asp His Leu Ala Ser Asp Pro Leu Thr Pro Glu Phe Ile Lys 
             20                  25                  30
Pro Thr Met Asp Leu Ala Ser Pro Glu Ala Ala Pro Ala Ala Pro Thr 
         35                  40                  45
Ala Leu Pro Ser Phe Ser Thr Phe Met Asp Gly Tyr Thr Gly Glu Phe 
     50                  55                  60
Asp Thr Phe Leu Tyr Gln Leu Pro Gly Thr Val Gln Pro Cys Ser Ser 
 65                  70                  75                  80
Ala Ser Ser Ser Ala Ser Ser Thr Ser Ser Ser Ser Ala Thr Ser Pro 
                 85                  90                  95
Ala Ser Ala Ser Phe Lys Phe Glu Asp Phe Gln Val Tyr Gly Cys Tyr 
             100                105                110
Pro Gly Pro Leu Ser Gly Pro Val Asp Glu Ala Leu Ser Ser Ser Gly 
         115                120                125
Ser Asp Tyr Tyr Gly Ser Pro Cys Ser Ala Pro Ser Pro Ser Thr Pro 
     130                135                140
Ser Phe Gln Pro Pro Gln Leu Ser Pro Trp Asp Gly Ser Phe Gly His 
 145                150                155                160
Phe Ser Pro Ser Gln Thr Tyr Glu Gly Leu Arg Ala Trp Thr Glu Gln 
                 165                170                175
Leu Pro Lys Ala Ser Gly Pro Pro Gln Pro Pro Ala Phe Phe Ser Phe 
             180                185                190
Ser Pro Pro Thr Gly Pro Ser Pro Ser Leu Ala Gln Ser Pro Leu Lys 
         195                200                205
Leu Phe Pro Ser Gln Ala Thr His Gln Leu Gly Glu Gly Glu Ser Tyr 
     210                215                220
Ser Met Pro Thr Ala Phe Pro Gly Leu Ala Pro Thr Ser Pro His Leu 
 225                230                235                240
Glu Gly Ser Gly Ile Leu Asp Thr Pro Val Thr Ser Thr Lys Ala Arg 
                 245                250                255
Ser Gly Ala Pro Gly Gly Ser Glu Gly Arg Cys Ala Val Cys Gly Asp 
             260                265                270
Asn Ala Ser Cys Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys 
         275                280                285
Gly Phe Phe Lys Arg Thr Val Gln Lys Asn Ala Lys Tyr Ile Cys Leu 
     290                295                300
Ala Asn Lys Asp Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln 
 305                310                315                320
Phe Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val 
                 325                330                335
Val Arg Thr Asp Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys 
             340                345                350
Pro Lys Gln Pro Pro Asp Ala Ser Pro Ala Asn Leu Leu Thr Ser Leu 
         355                360                365
Val Arg Ala His Leu Asp Ser Gly Pro Ser Thr Ala Lys Leu Asp Tyr 
     370                375                380
Ser Lys Phe Gln Glu Leu Val Leu Pro His Phe Gly Lys Glu Asp Ala 
 385                390                395                400
Gly Asp Val Gln Gln Phe Tyr Asp Leu Leu Ser Gly Ser Leu Glu Val 
                 405                410                415
Ile Arg Lys Trp Ala Glu Lys Ile Pro Gly Phe Ala Glu Leu Ser Pro 
             420                425                430
Ala Asp Gln Asp Leu Leu Leu Glu Ser Ala Phe Leu Glu Leu Phe Ile 
         435                440                445
Leu Arg Leu Ala Tyr Arg Ser Lys Pro Gly Glu Gly Lys Leu Ile Phe 
     450                455                460
Cys Ser Gly Leu Val Leu His Arg Leu Gln Cys Ala Arg Gly Phe Gly 
 465                470                475                480
Asp Trp Ile Asp Ser Ile Leu Ala Phe Ser Arg Ser Leu His Ser Leu 
                 485                490                495
Leu Val Asp Val Pro Ala Phe Ala Cys Leu Ser Ala Leu Val Leu Ile 
             500                505                510
Thr Asp Arg His Gly Leu Gln Glu Pro Arg Arg Val Glu Glu Leu Gln 
         515                520                525
Asn Arg Ile Ala Ser Cys Leu Lys Glu His Val Ala Ala Val Ala Gly 
     530                535                540
Glu Pro Gln Pro Ala Ser Cys Leu Ser Arg Leu Leu Gly Lys Leu Pro 
 545                550                555                560
Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                 565                570                575
Lys Leu Glu Asp Leu Val Pro Pro Pro Pro Ile Ile Asp Lys Ile Phe 
             580                585                590
Met Asp Thr Leu Pro Phe 
         595



<210> 8186
<211> 1812
<212> DNA
<213> Rattus norvegicus
<308> U17565
<400> 8186

ctcagagat  aggagcaga  agctgagag  attaagaac  aaatgacgg  gaaggaatg  60
gaaaaggtg  ttgaaatga  tcaggacca  aacctgtac  acaatctct  cactagcct  120
ttccctacg  tccacggca  tgatgaagt  aaacgtggc  tcttgctga  gctgttcgg  180
ggcgttccc  agacaacag  ggaaggaac  tctcttcgt  gggatataa  tgtttgcat  240
gttggggat  caagtacag  taagagcca  tttctcaag  atgtggatg  gttcagtcc  300
agagctgtg  ataccagtg  caaggcctc  agtgcttcc  gcttgacag  agctgtggt  360
agagatgag  aatctcacg  gtttgtcat  gaggctgga  cgttgatgc  ggctgataa  420
ggtgtctgt  gcattgatg  gtttgataa  atggacatg  gggaccaag  tgctattca  480
gaagctatg  agcagcaga  catatctat  actaaagcc  gagtgaagg  aactctgaa  540
gccaggaca  ccattttag  tgcagcaaa  cctgtcagc  gacactacg  caggtcaaa  600
tctctgaaa  agaacatca  tctgtcagc  cccatcatg  cccgctttg  cctcttctt  660
attttggtg  atgagtgca  tgaggtgac  gattatgct  ttgccaggc  catagtaga  720
ttgcattcg  ggatcgaag  atcgataga  cgggtttat  cccttgatg  tataagaag  780
tatcttctc  tcgcccgac  gtttaagcc  aagatttcc  aagagtcag  ggacttcat  840
gtggagcag  acaaacgcc  ccgccagag  gatggctct  ggatcacca  gtcgtcgtg  900
agaatcact  tgagacagc  tgagagcat  atccgactc  cagaatcga  ggcccgcat  960
cactgctgt  atgaggtcc  gcctaaaca  gtgaaggaa  cttttcgat  actgaataa  1020
tcgatcatc  gtgtagaaa  gcctgacgt  aatctagat  aagaggaag  gatccagat  1080
gagacggat  agggaccag  aggcatcaa  ggtcatgct  acagccctg  ccctgtgaa  1140
gggttcaat  gctctggtg  agatgccag  caggagacc  ttcccaagc  ctcccttag  1200
ttggccttt  ctgaatact  ccgaatctc  aacctcatc  tgcttcacc  caggaaaat  1260
gaagaagag  aggatgagt  agccctaaa  aggagcgag  tggtcaact  gtacctgaa  1320
gaaatcgag  cggaaatcg  ctctgaaga  gagctcata  ataagaaga  gatcataga  1380
aaggttgtt  atcgtctca  acactacga  cacgttctg  ttgagctca  ccaggctgg  1440
ctgaaaggc  ccagtgaag  aagcgagag  tatgaggaa  atccttacc  ggtagtcaa  1500
ccgaactac  tgcttgaag  ttgagatat  gaaggtgac  tacggccag  aaccggggg  1560
ggcctacct  agccgggac  tgggcatgc  ctgagaccg  ttctggagc  atgcttggg  1620
gacagttga  aagagacag  tgaacagtg  gtaatgccg  gatttcatg  tggacatgc  1680
tgggtactt  gtgcttttc  tacacatga  ataaaaagt  tttcagaaa  catgattgg  1740
atccaactt  aacaggaca  gacaaagtg  ccacgcatg  gccagcatt  aatccacgg  1800
catgaactc  gc  1812



<210> 8187
<211> 507
<212> PRT
<213> Rattus norvegicus
<308> Q62724
<400> 8187

Leu Arg Asp Glu Glu Gln Thr Ala Glu Ser Ile Lys Asn Gln Met Thr 
  1               5                  10                  15
Val Lys Glu Trp Glu Lys Val Phe Glu Met Ser Gln Asp Gln Asn Leu 
             20                  25                  30
Tyr His Asn Leu Cys Thr Ser Leu Phe Pro Thr Ile His Gly Asn Asp 
         35                  40                  45
Glu Val Lys Arg Gly Val Leu Leu Met Leu Phe Gly Gly Val Pro Lys 
     50                  55                  60
Thr Thr Gly Glu Gly Thr Ser Leu Arg Gly Asp Ile Asn Val Cys Ile 
 65                  70                  75                  80
Val Gly Asp Pro Ser Thr Ala Lys Ser Gln Phe Leu Lys His Val Asp 
                 85                  90                  95
Glu Phe Ser Pro Arg Ala Val Tyr Thr Ser Gly Lys Ala Ser Ser Ala 
             100                105                110
Ser Gly Leu Thr Ala Ala Val Val Arg Asp Glu Glu Ser His Glu Phe 
         115                120                125
Val Ile Glu Ala Gly Ala Leu Met Leu Ala Asp Asn Gly Val Cys Cys 
     130                135                140
Ile Asp Glu Phe Asp Lys Met Asp Met Arg Asp Gln Val Ala Ile His 
 145                150                155                160
Glu Ala Met Glu Gln Gln Thr Ile Ser Ile Thr Lys Ala Gly Val Lys 
                 165                170                175
Ala Thr Leu Asn Ala Arg Thr Ser Ile Leu Ala Ala Ala Asn Pro Val 
             180                185                190
Ser Gly His Tyr Asp Arg Ser Lys Ser Leu Lys Gln Asn Ile Asn Leu 
         195                200                205
Ser Ala Pro Ile Met Ser Arg Phe Asp Leu Phe Phe Ile Leu Val Asp 
     210                215                220
Glu Cys Asn Glu Val Thr Asp Tyr Ala Ile Ala Arg Arg Ile Val Asp 
 225                230                235                240
Leu His Ser Arg Ile Glu Glu Ser Ile Asp Arg Val Tyr Ser Leu Asp 
                 245                250                255
Asp Ile Arg Arg Tyr Leu Leu Phe Ala Arg Gln Phe Lys Pro Lys Ile 
             260                265                270
Ser Lys Glu Ser Glu Asp Phe Ile Val Glu Gln Tyr Lys Arg Leu Arg 
         275                280                285
Gln Arg Asp Gly Ser Gly Ile Thr Lys Ser Ser Trp Arg Ile Thr Val 
     290                295                300
Arg Gln Leu Glu Ser Met Ile Arg Leu Ser Glu Ser Met Ala Arg Met 
 305                310                315                320
His Cys Cys Asp Glu Val Gln Pro Lys His Val Lys Glu Ala Phe Arg 
                 325                330                335
Leu Leu Asn Lys Ser Ile Ile Arg Val Glu Thr Pro Asp Val Asn Leu 
             340                345                350
Asp Gln Glu Glu Glu Ile Gln Met Glu Thr Asp Glu Gly Pro Gly Gly 
         355                360                365
Ile Asn Gly His Ala Asp Ser Pro Ala Pro Val Asn Gly Phe Asn Gly 
     370                375                380
Ser Gly Glu Asp Ala Ser Gln Glu Thr Val Pro Lys Pro Ser Leu Arg 
 385                390                395                400
Leu Ala Phe Ala Glu Tyr Cys Arg Ile Ser Asn Leu Ile Val Leu His 
                 405                410                415
Leu Arg Lys Met Glu Glu Glu Glu Asp Glu Ser Ala Leu Lys Arg Ser 
             420                425                430
Glu Leu Val Asn Trp Tyr Leu Lys Glu Ile Glu Ser Glu Ile Asp Ser 
         435                440                445
Glu Glu Glu Leu Ile Asn Lys Lys Arg Ile Ile Glu Lys Val Val His 
     450                455                460
Arg Leu Thr His Tyr Asp His Val Leu Ile Glu Leu Thr Gln Ala Gly 
 465                470                475                480
Leu Lys Gly Ser Ser Glu Gly Ser Glu Ser Tyr Glu Glu Asp Pro Tyr 
                 485                490                495
Leu Val Val Asn Pro Asn Tyr Leu Leu Glu Asp 
             500                505



<210> 8188
<211> 2917
<212> DNA
<213> Homo sapiens
<308> D84557
<400> 8188

ggaaaaaag  gacttgtgg  ggtcgagcg  ggcgcaggc  aatcctcgg  actaagcaa  60
tatggacct  gcggcggca  cggagccgg  cgccggcag  cagcacctg  aggtccgcg  120
cgaggtggc  gagaagtgc  agaaactgt  cctggactt  ttggaggag  ttcagagca  180
cgatggaga  attaaatac  tgcaattag  agaggaact  attcgtcct  agagaaaca  240
attggttgt  agttttgtg  acctggaac  atttaacca  caactttcc  ccaccattc  300
agaggagtt  tatagagtt  acccttacc  gtgtcgggc  ttgaaaaca  tcgtcaaag  360
ccgtaaaga  atccctctt  ccaaggatt  ttatgttgc  ttccaagac  tgcctacca  420
acacaagat  cgagagctc  cctcatcca  aattggttt  ctcactcgc  tcagtgggc  480
ggtggtgcg  actcaccca  ttcacccag  gcttgtgag  ggaactttt  tgtgcttgg  540
ctgtcagac  gtgatcagg  atgtagaac  gcagttcaa  tacacacag  caaacatct  600
ccgaaatcc  gtttgtgcc  acaggagga  attcttact  gatacaaat  aatcaagat  660
tgttgattt  caaaaggtt  gtattcaag  gacccaagc  gagcttcct  gagggagta  720
cccccgcag  ttagaagta  ttttaaggg  tgaagctgt  gaatcagct  aagctggtg  780
caagtgtga  tttacaggg  cactgattg  tgtgcctga  gtctccaag  ttagcacac  840
aggagcacg  gcagaaact  attcccgtg  cagtggtgt  gatggatat  agacagaag  900
cattcgagg  ctccgggcc  ttggtgtta  ggacctttc  tataggctg  tctttcttg  960
ctgctgtgt  gcgccaacc  acccaaggt  tggggggaa  gagctcaga  atgaggaac  1020
gacagctga  agcattaag  accaaatga  tgtgaaaga  tgggagaaa  tgtttgaga  1080
gagtcaaga  aaaaatcta  accacaatc  ttgtaccag  ctgttccct  ctatacatg  1140
caatgatga  gtaaaacgg  gtgtcctgc  gatgctctt  ggtggcgtt  caaagacaa  1200
aggagaagg  acctctctt  gaggggaca  aaatgtttg  attgttggt  acccaagta  1260
agctaagag  caatttctc  agcacgtgg  ggagttcag  cccagagct  tctacacca  1320
tggtaaagc  tccagtgct  ctggcttaa  agcagctgt  gtgagagat  aagaatctc  1380
tgagtttgt  attgaggct  gagctttga  gttggctga  aatggtgtg  gttgtattg  1440
tgaatttga  aagatggac  tgcgggatc  agttgctat  catgaagct  tggaacagc  1500
gaccatatc  atcactaaa  caggagtga  ggctactct  aacgcccgg  cgtccattt  1560
ggcagcagc  aacccaatc  gtggacact  tgacagatc  aaatcattg  aacagaata  1620
aaatttgtc  gctcccatc  tgtcccgat  cgatctctt  tttatcctt  tggatgaat  1680
taatgaggt  acagattat  ccattgcca  gcgcatagt  gatttgcat  caagaattg  1740
ggaatcaat  gatcgtgtc  attccctcg  tgatatcag  agatatctt  tctttgcaa  1800
acagtttaa  cccaagatt  ccaaagagt  agaggactt  attgtggag  aatataaac  1860
tctccgcca  agagatggt  ctggagtga  caagtcttc  tggaggatt  cagtgcgac  1920
gcttgagag  atgattcgt  tctctgaag  tatggctcg  atgcactgc  gtgatgagg  1980
ccaacctaa  catgtgaag  aagctttcc  gttactgaa  aaatcaatc  tccgtgtgg  2040
aacacctga  gtcaatcta  atcaagagg  agagatcca  atggaggta  atgagggtg  2100
tggtggcat  aatggtcat  ctgacagcc  tgctcctgt  aacgggatc  atggctaca  2160
tgaagacat  aatcaagag  ctgctccca  agcctcctt  aggctgggc  tctctgagt  2220
ctgccgaat  tctaacctt  ttgtgcttc  cctcagaaa  gtggaagaa  aagaggacg  2280
gtcagcatt  aagaggagc  agcttgtta  ctggtactt  aaggaaatc  aatcagaga  2340
agactctga  gaagaactt  taaataaaa  aagaatcat  gagaaagtt  ttcatcgac  2400
cacacacta  gatcatgtt  taattgagc  cacccaggc  ggattgaaa  gctccacag  2460
gggaagtga  agctatgaa  aagatccct  cttggtagt  aaccctaac  acttgctcg  2520
agattgaga  agtgaaagt  actgaccag  gctgaggaa  tgtggcaca  cacctcgtg  2580
cctggagcc  ggctggagc  ctgctaggg  cagaagtgt  tctggaagt  atgcttcca  2640
gatttgttt  cagaaacaa  aattgagtt  atggtccta  gtgtcacat  catcacagg  2700
ttcatacca  cacaggctt  agcacttcc  ttggtgtgt  tcctgtccc  gtgaagttg  2760
aaccaaata  tgtgtagtc  ctataacca  tacctttgt  ttcatgtgt  agaaaaggc  2820
cattacttt  aaggtatgt  ctgtcctat  gagcaaata  ctttttttc  attgccagc  2880
actgctttt  ttcatcaaa  taaaataac  tgttctg  2917



<210> 8189
<211> 821
<212> PRT
<213> Homo sapiens
<308> Q14566
<400> 8189

Met Asp Leu Ala Ala Ala Ala Glu Pro Gly Ala Gly Ser Gln His Leu 
  1               5                  10                  15
Glu Val Arg Asp Glu Val Ala Glu Lys Cys Gln Lys Leu Phe Leu Asp 
             20                  25                  30
Phe Leu Glu Glu Phe Gln Ser Ser Asp Gly Glu Ile Lys Tyr Leu Gln 
         35                  40                  45
Leu Ala Glu Glu Leu Ile Arg Pro Glu Arg Asn Thr Leu Val Val Ser 
     50                  55                  60
Phe Val Asp Leu Glu Gln Phe Asn Gln Gln Leu Ser Thr Thr Ile Gln 
 65                  70                  75                  80
Glu Glu Phe Tyr Arg Val Tyr Pro Tyr Leu Cys Arg Ala Leu Lys Thr 
                 85                  90                  95
Phe Val Lys Asp Arg Lys Glu Ile Pro Leu Ala Lys Asp Phe Tyr Val 
             100                105                110
Ala Phe Gln Asp Leu Pro Thr Arg His Lys Ile Arg Glu Leu Thr Ser 
         115                120                125
Ser Arg Ile Gly Leu Leu Thr Arg Ile Ser Gly Gln Val Val Arg Thr 
     130                135                140
His Pro Val His Pro Glu Leu Val Ser Gly Thr Phe Leu Cys Leu Asp 
 145                150                155                160
Cys Gln Thr Val Ile Arg Asp Val Glu Gln Gln Phe Lys Tyr Thr Gln 
                 165                170                175
Pro Asn Ile Cys Arg Asn Pro Val Cys Ala Asn Arg Arg Arg Phe Leu 
             180                185                190
Leu Asp Thr Asn Lys Ser Arg Phe Val Asp Phe Gln Lys Val Arg Ile 
         195                200                205
Gln Glu Thr Gln Ala Glu Leu Pro Arg Gly Ser Ile Pro Arg Ser Leu 
     210                215                220
Glu Val Ile Leu Arg Ala Glu Ala Val Glu Ser Ala Gln Ala Gly Asp 
 225                230                235                240
Lys Cys Asp Phe Thr Gly Thr Leu Ile Val Val Pro Asp Val Ser Lys 
                 245                250                255
Leu Ser Thr Pro Gly Ala Arg Ala Glu Thr Asn Ser Arg Val Ser Gly 
             260                265                270
Val Asp Gly Tyr Glu Thr Glu Gly Ile Arg Gly Leu Arg Ala Leu Gly 
         275                280                285
Val Arg Asp Leu Ser Tyr Arg Leu Val Phe Leu Ala Cys Cys Val Ala 
     290                295                300
Pro Thr Asn Pro Arg Phe Gly Gly Lys Glu Leu Arg Asp Glu Glu Gln 
 305                310                315                320
Thr Ala Glu Ser Ile Lys Asn Gln Met Thr Val Lys Glu Trp Glu Lys 
                 325                330                335
Val Phe Glu Met Ser Gln Asp Lys Asn Leu Tyr His Asn Leu Cys Thr 
             340                345                350
Ser Leu Phe Pro Thr Ile His Gly Asn Asp Glu Val Lys Arg Gly Val 
         355                360                365
Leu Leu Met Leu Phe Gly Gly Val Pro Lys Thr Thr Gly Glu Gly Thr 
     370                375                380
Ser Leu Arg Gly Asp Ile Asn Val Cys Ile Val Gly Asp Pro Ser Thr 
 385                390                395                400
Ala Lys Ser Gln Phe Leu Lys His Val Glu Glu Phe Ser Pro Arg Ala 
                 405                410                415
Val Tyr Thr Ser Gly Lys Ala Ser Ser Ala Ala Gly Leu Thr Ala Ala 
             420                425                430
Val Val Arg Asp Glu Glu Ser His Glu Phe Val Ile Glu Ala Gly Ala 
         435                440                445
Leu Met Leu Ala Asp Asn Gly Val Cys Cys Ile Asp Glu Phe Asp Lys 
     450                455                460
Met Asp Val Arg Asp Gln Val Ala Ile His Glu Ala Met Glu Gln Gln 
 465                470                475                480
Thr Ile Ser Ile Thr Lys Ala Gly Val Lys Ala Thr Leu Asn Ala Arg 
                 485                490                495
Thr Ser Ile Leu Ala Ala Ala Asn Pro Ile Ser Gly His Tyr Asp Arg 
             500                505                510
Ser Lys Ser Leu Lys Gln Asn Ile Asn Leu Ser Ala Pro Ile Met Ser 
         515                520                525
Arg Phe Asp Leu Phe Phe Ile Leu Val Asp Glu Cys Asn Glu Val Thr 
     530                535                540
Asp Tyr Ala Ile Ala Arg Arg Ile Val Asp Leu His Ser Arg Ile Glu 
 545                550                555                560
Glu Ser Ile Asp Arg Val Tyr Ser Leu Asp Asp Ile Arg Arg Tyr Leu 
                 565                570                575
Leu Phe Ala Arg Gln Phe Lys Pro Lys Ile Ser Lys Glu Ser Glu Asp 
             580                585                590
Phe Ile Val Glu Gln Tyr Lys His Leu Arg Gln Arg Asp Gly Ser Gly 
         595                600                605
Val Thr Lys Ser Ser Trp Arg Ile Thr Val Arg Gln Leu Glu Ser Met 
     610                615                620
Ile Arg Leu Ser Glu Ala Met Ala Arg Met His Cys Cys Asp Glu Val 
 625                630                635                640
Gln Pro Lys His Val Lys Glu Ala Phe Arg Leu Leu Asn Lys Ser Ile 
                 645                650                655
Ile Arg Val Glu Thr Pro Asp Val Asn Leu Asp Gln Glu Glu Glu Ile 
             660                665                670
Gln Met Glu Val Asp Glu Gly Ala Gly Gly Ile Asn Gly His Ala Asp 
         675                680                685
Ser Pro Ala Pro Val Asn Gly Ile Asn Gly Tyr Asn Glu Asp Ile Asn 
     690                695                700
Gln Glu Ser Ala Pro Lys Ala Ser Leu Arg Leu Gly Phe Ser Glu Tyr 
 705                710                715                720
Cys Arg Ile Ser Asn Leu Ile Val Leu His Leu Arg Lys Val Glu Glu 
                 725                730                735
Glu Glu Asp Glu Ser Ala Leu Lys Arg Ser Glu Leu Val Asn Trp Tyr 
             740                745                750
Leu Lys Glu Ile Glu Ser Glu Ile Asp Ser Glu Glu Glu Leu Ile Asn 
         755                760                765
Lys Lys Arg Ile Ile Glu Lys Val Ile His Arg Leu Thr His Tyr Asp 
     770                775                780
His Val Leu Ile Glu Leu Thr Gln Ala Gly Leu Lys Gly Ser Thr Glu 
 785                790                795                800
Gly Ser Glu Ser Tyr Glu Glu Asp Pro Tyr Leu Val Val Asn Pro Asn 
                 805                810                815
Tyr Leu Leu Glu Asp 
             820



<210> 8190
<211> 1203
<212> DNA
<213> Rattus norvegicus
<308> U17607
<400> 8190

gggggatag  agtgactta  attctccct  tccgaggag  tataaataa  tccatgtaa  60
attaatgca  ttctcggtg  caaaatgtc  acagaagga  ggtttggca  taccagcag  120
agtgatgcc  agcaaagcc  ccagtcctt  tggcccaga  tcatggaag  aatccgaaa  180
ttaacagtg  aagatttcc  agtacaaga  ctaccactg  ctcgtatta  gaagattat  240
aaactggat  aagatgtga  gatgatcag  gcagaagcc  ctgtgctgt  tgctaaggc  300
gcccagatc  tcatcacag  gctgactct  cgagcctgg  tccacacag  ggataacaa  360
cgtcgtact  ttcagagga  tgatattgc  atggcaatt  caaaatttg  tcagtttga  420
tttctcatc  acattgttc  aagagatga  ctgaaacct  caaagcgcc  ggaggaggt  480
cgccagtct  tgactcccg  ggagcctgt  cagtactac  tcacgctgg  tcagcagcc  540
actgctgtc  aggtccagg  acagcagca  ggccagcag  ccaccagtt  tacgaccac  600
atccagcct  gccagatca  cattgcgca  cctcaacag  gtcagacca  acccgtgac  660
atgcaggtt  gagaaggtc  gcaggtgca  attgtgcag  cccaacctc  gggtcaggc  720
cagcaggcc  agagtggta  tggacagac  atgcaggtg  tgcagcaga  cattaccaa  780
acaggagag  tccaacaga  cccggtgca  ctgaatgcc  gccagttgc  gtatatccg  840
ttagcccag  ctgtatcag  cacccaagt  gtgcaggga  agatccaga  ccttgctac  900
aatgcccaa  agatcacac  gacagaggt  caacaagga  agcagcagt  cagccagtt  960
acagacgga  agcagctgt  ccagatcca  caagtcacc  tgcctgcag  ccaagacct  1020
gcccagccc  tgtttattc  gtcagccaa  cagccctct  atgggcaga  cccccaggt  1080
actggagac  gaggcctga  ctgcaaagc  aaggaaccc  aacacaata  ttgccatag  1140
gcccccagg  gatggggac  caccttccc  caccagagg  cccgggact  cattgcctc  1200
tgc  1203



<210> 8191
<211> 335
<212> PRT
<213> Rattus norvegicus
<308> Q62725
<400> 8191

Met Ser Thr Glu Gly Gly Phe Gly Ser Thr Ser Ser Ser Asp Ala Gln 
  1               5                  10                  15
Gln Ser Leu Gln Ser Phe Trp Pro Arg Val Met Glu Glu Ile Arg Asn 
             20                  25                  30
Leu Thr Val Lys Asp Phe Arg Val Gln Glu Leu Pro Leu Ala Arg Ile 
         35                  40                  45
Lys Lys Ile Met Lys Leu Asp Glu Asp Val Lys Met Ile Ser Ala Glu 
     50                  55                  60
Ala Pro Val Leu Phe Ala Lys Ala Ala Gln Ile Phe Ile Thr Glu Leu 
 65                  70                  75                  80
Thr Leu Arg Ala Trp Ile His Thr Glu Asp Asn Lys Arg Arg Thr Leu 
                 85                  90                  95
Gln Arg Asn Asp Ile Ala Met Ala Ile Thr Lys Phe Asp Gln Phe Asp 
             100                105                110
Phe Leu Ile Asp Ile Val Pro Arg Asp Glu Leu Lys Pro Pro Lys Arg 
         115                120                125
Gln Glu Glu Val Arg Gln Ser Val Thr Pro Ala Glu Pro Val Gln Tyr 
     130                135                140
Tyr Phe Thr Leu Ala Gln Gln Pro Thr Ala Val Gln Val Gln Gly Gln 
 145                150                155                160
Gln Gln Gly Gln Gln Thr Thr Ser Ser Thr Thr Thr Ile Gln Pro Gly 
                 165                170                175
Gln Ile Ile Ile Ala Gln Pro Gln Gln Gly Gln Thr Thr Pro Val Thr 
             180                185                190
Met Gln Val Gly Glu Gly Gln Gln Val Gln Ile Val Gln Ala Gln Pro 
         195                200                205
Gln Gly Gln Ala Gln Gln Ala Gln Ser Gly Thr Gly Gln Thr Met Gln 
     210                215                220
Val Met Gln Gln Ile Ile Thr Asn Thr Gly Glu Ile Gln Gln Ile Pro 
 225                230                235                240
Val Gln Leu Asn Ala Gly Gln Leu Gln Tyr Ile Arg Leu Ala Gln Pro 
                 245                250                255
Val Ser Gly Thr Gln Val Val Gln Gly Gln Ile Gln Thr Leu Ala Thr 
             260                265                270
Asn Ala Gln Gln Ile Thr Gln Thr Glu Val Gln Gln Gly Gln Gln Gln 
         275                280                285
Phe Ser Gln Phe Thr Asp Gly Gln Gln Leu Tyr Gln Ile Gln Gln Val 
     290                295                300
Thr Met Pro Ala Gly Gln Asp Leu Ala Gln Pro Met Phe Ile Gln Ser 
 305                310                315                320
Ala Asn Gln Pro Ser Asp Gly Gln Thr Pro Gln Val Thr Gly Asp 
                 325                330                335



<210> 8192
<211> 2684
<212> DNA
<213> Homo sapiens
<308> AK055329
<400> 8192

ttttaatgg  tttagattg  gtgtccctc  atcttgcct  aagtgggca  ttctggaat  60
gtctaccat  aacttgaga  gtcgttttt  cttggtagt  caaattctg  gaggctgga  120
gtctcagag  agcattttg  ttgaacact  cgtgcagga  tgcagcttc  tcccattag  180
attttcctc  tggaagagt  ctgcagtga  gttagctct  gaaggccag  gggaaattt  240
ctccagagc  gaggcaata  ttgcctgtt  gccacaaga  gcttcccct  gcaacaaag  300
caggctggg  agccagggc  ggtggtttc  ggaccccgc  gatagagac  tagtctatc  360
atgctccca  aaccccttt  atttcctct  aattgaggg  gtgaatgtc  gcagtcctc  420
tctgctgac  atcatcttt  ctgagctac  gttctctga  gtggtaacc  ccttggtcc  480
cttttcatc  ccagctcaa  acactaata  tttcatggt  cactggagc  ttaagagcc  540
gagttaagg  ttttagcac  caattaaat  cagcatgtg  tattattgt  ttatctgag  600
tttaatcgt  agcatgaga  actctaagg  cgctttcgt  gctttggtt  cccatgatg  660
ggttttcta  gaaaggttt  ttgattctg  ttccccttg  gaggtgttt  gccagaagc  720
agtgctgaa  accaaagat  ctaaaagcc  cacagaccc  ccatccagc  tggctcttg  780
ggacagaga  ggttaagca  tccagcttt  gcctccaaa  tgtgcagca  ggggcaggg  840
agtgtgagg  ctatgatgc  gaatgatgg  tgtttgctt  gggatcctg  cagatgctg  900
atctcttta  agatgggag  gaaagaggc  cacacttaa  gtacaggca  tctgatgat  960
tcagtcaga  aaattccta  gataagctg  gatcatgta  ctaagagct  gcaaataat  1020
agcatgcag  catgctgtt  tcacctttg  gacaggatc  tctgggagt  ttttctgaa  1080
tccattcag  gaatatatt  tcttctgtg  tgtgtgact  gtgggatgt  gatgttctg  1140
ttttgcttg  tttgacctc  gtttaaaag  gactttttt  agggcaggc  tctttggag  1200
gcttgaggg  tagggggca  tcaacatct  cggtcatgg  aagtttgcc  gtttgagat  1260
atactcaat  tcttatggt  tctttgtct  tgcccctgc  ctaggtgca  ctgaatgcc  1320
gccagctgc  gtatatccg  ttagcccag  ctgtatcag  cactcaagt  gtgcaggga  1380
agatccaga  acttgccac  aatgctcaa  aggtatgtg  cccagagac  caaggcctg  1440
gttggagac  aggagcaga  ggcttctga  aggaaagga  cgctcagca  acagctgtc  1500
tgccacctc  tccttcaac  agaagcacc  cccccacac  ctccatatc  ttctgcacc  1560
aagaggcat  ggtggtaat  ggaacatta  attcaaagt  ttttctctt  ccatcttgt  1620
ctcaagggg  aaagaaatg  aagtcaggg  aagcctcga  ggtgcctga  agaaacctt  1680
caggtgtgc  cacccatca  acctgggaa  tgttcgaca  atcgcctga  cgtcaggct  1740
tttccatct  taaacccaa  tggctgttg  gttctggca  ctcctgtgc  ctttggaaa  1800
cttacttag  ttttacccc  acctcctct  gcatcccta  ccagaaaaa  tgcccttct  1860
ctctcctct  gtgccctac  atattgatg  ctatgagtc  cagatggtg  gggggctgc  1920
tccctgggc  tgggggtgt  gagggacat  ggtattact  gcagaagat  gggggtgct  1980
gtcaagggg  ggcattgtt  atggattct  ttgcctcag  cccaaaaaa  gcagcgatc  2040
tttaagagc  ggacccgtc  ggcccagct  catttctgg  gatgtatct  ttgacagtg  2100
tgacagagc  gagtttgta  agcaggtct  caaagatct  atttgggaa  atacgagga  2160
tgagccaaa  gcaaggctt  tgagttcca  atagtctct  ggatcatta  gggctgttt  2220
tgtgcccac  ccccggctt  cctaaggac  cggcttttc  gtaactgat  ctgactcac  2280
cccttcccc  agcccctct  tttaacctc  taagattct  ccctgggat  caaaaaaca  2340
aacggcatg  gagtgggag  aaatgagaa  gaagcttct  ggttcctca  aagtcagtt  2400
ggggctggg  acagtgggt  acgcctgta  tcccagcac  ttgggaggg  ggctgaggc  2460
ggtgatcac  tgaggtcgg  agtttgaga  cagcctggc  aacatggca  aaccgtttc  2520
actaaaaat  caaaattag  tgggcgtgg  ggtgcatgc  tgtcatccc  gctacttgg  2580
aggctgaga  acaagaatc  cttgaaccc  ggaggtgga  gttgcagtg  gctgagatt  2640
tgccactgc  ctccagcct  ggcgacaga  tgagactct  tctc  2684



<210> 8193
<211> 458
<212> PRT
<213> Homo sapiens
<308> BAA12818
<400> 8193

Met Ser Thr Glu Gly Gly Phe Gly Gly Thr Ser Ser Ser Asp Ala Gln 
  1               5                  10                  15
Gln Ser Leu Gln Ser Phe Trp Pro Arg Val Met Glu Glu Ile Arg Asn 
             20                  25                  30
Leu Thr Val Lys Asp Phe Arg Val Gln Glu Leu Pro Leu Ala Arg Ile 
         35                  40                  45
Lys Lys Ile Met Lys Leu Asp Glu Asp Val Lys Met Ile Ser Ala Glu 
     50                  55                  60
Ala Pro Val Leu Phe Ala Lys Ala Ala Gln Ile Phe Ile Thr Glu Leu 
 65                  70                  75                  80
Thr Leu Arg Ala Trp Ile His Thr Glu Asp Asn Lys Arg Arg Thr Leu 
                 85                  90                  95
Gln Arg Asn Asp Ile Ala Met Ala Ile Thr Lys Phe Asp Gln Phe Asp 
             100                105                110
Phe Leu Ile Asp Ile Val Pro Arg Asp Glu Leu Lys Pro Pro Lys Arg 
         115                120                125
Gln Glu Glu Val Arg Gln Ser Val Thr Pro Ala Glu Pro Val Gln Tyr 
     130                135                140
Tyr Phe Thr Leu Ala Gln Gln Pro Thr Ala Val Gln Val Gln Gly Gln 
 145                150                155                160
Gln Gln Gly Gln Gln Thr Thr Ser Ser Thr Thr Thr Ile Gln Pro Gly 
                 165                170                175
Gln Ile Ile Ile Ala Gln Pro Gln Gln Gly Gln Thr Thr Pro Val Thr 
             180                185                190
Met Gln Val Gly Glu Gly Gln Gln Val Gln Ile Val Gln Ala Gln Pro 
         195                200                205
Gln Gly Gln Ala Gln Gln Ala Gln Ser Gly Thr Gly Gln Thr Met Gln 
     210                215                220
Val Met Gln Gln Ile Ile Thr Asn Thr Gly Glu Ile Gln Gln Ile Pro 
 225                230                235                240
Val Gln Leu Asn Ala Gly Gln Leu Gln Tyr Ile Arg Leu Ala Gln Pro 
                 245                250                255
Val Ser Gly Thr Gln Val Val Gln Gly Gln Ile Gln Thr Leu Ala Thr 
             260                265                270
Asn Ala Gln Gln Gly Gln Arg Asn Ala Ser Gln Gly Lys Pro Arg Arg 
         275                280                285
Cys Leu Lys Glu Thr Leu Gln Ile Thr Gln Thr Glu Val Gln Gln Gly 
     290                295                300
Gln Gln Gln Phe Ser Gln Phe Thr Asp Gly Gln Arg Asn Ser Val Gln 
 305                310                315                320
Gln Ala Arg Val Ser Glu Leu Thr Gly Glu Ala Glu Pro Arg Glu Val 
                 325                330                335
Lys Ala Thr Gly Asn Ser Thr Pro Cys Thr Ser Ser Leu Pro Thr Thr 
             340                345                350
His Pro Pro Ser His Arg Ala Gly Ala Ser Cys Val Cys Cys Ser Gln 
         355                360                365
Pro Gln Gln Ser Ser Thr Ser Pro Pro Pro Ser Asp Ala Leu Gln Trp 
     370                375                380
Val Val Val Glu Val Ser Gly Thr Pro Asn Gln Leu Glu Thr His Arg 
 385                390                395                400
Glu Leu His Ala Pro Leu Pro Gly Met Thr Ser Leu Ser Pro Leu His 
                 405                410                415
Pro Ser Gln Gln Leu Tyr Gln Ile Gln Gln Val Thr Met Pro Ala Gly 
             420                425                430
Gln Asp Leu Ala Gln Pro Met Phe Ile Gln Ser Ala Asn Gln Pro Ser 
         435                440                445
Asp Gly Gln Ala Pro Gln Val Thr Gly Asp 
     450                455



<210> 8194
<211> 2383
<212> DNA
<213> Rattus norvegicus
<308> U17697
<400> 8194

gctaataag  gtgtccttt  ctgacggta  cgagaaacc  cgccccgtc  gtacgtcct  60
gtggcgcgc  ggccggctg  gggtgtggg  agggcccgg  tcagtcgac  cccggaagg  120
cggggccgc  tcccgacgc  cacctacta  cttctccag  tccatcttt  ccgagaagc  180
gcagggacc  ccggcctcc  gcttaccgg  cggatcgaa  cagcggtcg  gatgtactg  240
tgggcttgc  gcagtcagg  ggctcggtg  tcgggcagg  gatggagca  gtgacagga  300
gcaacctgc  ttccacgct  ctcatcgcc  gcgccttca  gcttagcct  gtctacctg  360
tccgcctcg  agtgggcca  atggtccag  tgcccgctg  agcgaaaag  ccgccatat  420
tttactctc  aattccgtt  cttggccac  cgatagcat  tgggaaaag  ccaattgag  480
tcctggaaa  tgcatatga  aagtacgga  ctgtgttta  ctttaccat  gtgggcaag  540
ctttcactt  ccttttggg  agtgacgca  ccgccctgc  cttcaacag  aagaacgaa  600
acctgaatg  ggaagaggt  tacggtcgg  tgacaacgc  cgtgtttgg  aagggagtt  660
catacgacg  gccaaatgc  gttttcctg  aacagaaga  aatactaaa  agcggcctt  720
acatagccc  cttcaagca  tatgtttct  tcattgaaa  agaagcgaa  aagtacttt  780
aaagttggg  agaaagcgg  gaaagaaat  tgtttgaag  gctgtctga  ctcataatt  840
taacagcta  ccattgctt  catggaaag  aaattagaa  tcagctcaa  gagaaggtg  900
ctcagctgt  cgcagacct  gatggaggc  ttagccatg  cgcctggct  ttgccaggc  960
ggctgcccc  gccgagttt  aggcgcagg  acagagccc  tcgagagat  aagaatatt  1020
tctacaagg  catccagaa  cgtaggctg  caaaagaac  agccgagga  attcttcaa  1080
ctttactgg  ttctacata  aaggatggg  gtcctctga  ggacgacga  atcgcaggg  1140
tgctcatcg  actgctgct  gccggacag  acacatcct  caccaccag  gcctggatg  1200
gcttctttc  ggccagaga  aaaccactt  aagacaaat  ctacttaga  cagaaaacg  1260
tgtgcgggg  ggatctgcc  cccttaact  atgagcagt  gaaggatct  aatttactt  1320
atagatgca  aaaagaaac  ctaagactg  ggcctccta  aatgaccat  atgagaatg  1380
ccaagaccc  tcagactgt  gctgggtac  ccattcctc  aggacatca  gtgtgtgtt  1440
ctccaactg  caatcaaag  ctgaaagac  cctgggtag  acgcttgga  ttcaatcct  1500
accgctacc  acaggacaa  ccagcgtcg  gagagaagt  tgcctatgt  ccgtttgga  1560
ccgggcgcc  tcgttgtat  ggagaaaat  ttgcctatg  tcaaattaa  acaatttgg  1620
ccactatgc  tcgtttata  gaatttgac  tcatcaatg  atattttcc  agtgtgaat  1680
atacaacaa  gattcatac  ccagaaaac  cagtaatcc  ttacaaacg  agatcaaaa  1740
gaagaaagg  acaaggagc  agtgtggag  cgggactgc  agctgcagc  tggcagaga  1800
tgaagcttt  acacagctt  catactgta  tgtttttta  gtgtgtggt  ctgaaagcc  1860
gtttgattt  aatgtttta  taactcggt  atttttgtc  gacctaatg  catttgaaa  1920
agttataat  gttctgata  gatttcagg  aagccaagt  tatgttaga  atcgtttag  1980
ggagcctcg  tattcagag  tgatacaga  tatagcatc  aggtaacta  cttcagaag  2040
acacgttgc  gtagggaga  tccggcttg  aactagttt  ggaagtttt  agcctggtc  2100
gatgctaca  aggcaatgg  tcattggtg  ggttgggcc  cttctgtgc  taaagatgt  2160
agagggtga  ggataagtt  tctgcgaac  tctagatgg  gtgagtgcc  tttgtagtg  2220
taactgaga  caccactcc  gcgagatgg  agcaatctt  gaccttatc  tgataacct  2280
atttcctaa  aataataaa  actaaagag  acttatgtt  ttggttcca  aaaaatcca  2340
aatcaaatc  ttgtggaat  tttaatttt  attaaactc  tgc  2383



<210> 8195
<211> 503
<212> PRT
<213> Rattus norvegicus
<308> Q64654
<400> 8195

Met Val Leu Leu Gly Leu Leu Gln Ser Gly Gly Ser Val Leu Gly Gln 
  1               5                  10                  15
Ala Met Glu Gln Val Thr Gly Gly Asn Leu Leu Ser Thr Leu Leu Ile 
             20                  25                  30
Ala Cys Ala Phe Thr Leu Ser Leu Val Tyr Leu Phe Arg Leu Ala Val 
         35                  40                  45
Gly His Met Val Gln Leu Pro Ala Gly Ala Lys Ser Pro Pro Tyr Ile 
     50                  55                  60
Tyr Ser Pro Ile Pro Phe Leu Gly His Ala Ile Ala Phe Gly Lys Ser 
 65                  70                  75                  80
Pro Ile Glu Phe Leu Glu Asn Ala Tyr Glu Lys Tyr Gly Pro Val Phe 
                 85                  90                  95
Ser Phe Thr Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp 
             100                105                110
Ala Ala Ala Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu 
         115                120                125
Glu Val Tyr Gly Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala 
     130                135                140
Tyr Asp Val Pro Asn Ala Val Phe Leu Glu Gln Lys Lys Ile Leu Lys 
 145                150                155                160
Ser Gly Leu Asn Ile Ala His Phe Lys Gln Tyr Val Ser Ile Ile Glu 
                 165                170                175
Lys Glu Ala Lys Glu Tyr Phe Lys Ser Trp Gly Glu Ser Gly Glu Arg 
             180                185                190
Asn Val Phe Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His 
         195                200                205
Cys Leu His Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala 
     210                215                220
Gln Leu Tyr Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu 
 225                230                235                240
Leu Pro Gly Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala 
                 245                250                255
His Arg Glu Ile Lys Asn Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg 
             260                265                270
Leu Ser Lys Glu Pro Ala Glu Asp Ile Leu Gln Thr Leu Leu Asp Ser 
         275                280                285
Thr Tyr Lys Asp Gly Arg Pro Leu Thr Asp Asp Glu Ile Ala Gly Met 
     290                295                300
Leu Ile Gly Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser 
 305                310                315                320
Ala Trp Met Gly Phe Phe Leu Ala Arg Asp Lys Pro Leu Gln Asp Lys 
                 325                330                335
Cys Tyr Leu Glu Gln Lys Thr Val Cys Gly Glu Asp Leu Pro Pro Leu 
             340                345                350
Thr Tyr Glu Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys 
         355                360                365
Glu Thr Leu Arg Leu Arg Pro Pro Ile Met Thr Met Met Arg Met Ala 
     370                375                380
Lys Thr Pro Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln 
 385                390                395                400
Val Cys Val Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val 
                 405                410                415
Glu Arg Leu Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala 
             420                425                430
Ser Gly Glu Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg 
         435                440                445
Cys Ile Gly Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser 
     450                455                460
Thr Met Leu Arg Leu Tyr Glu Phe Asp Leu Ile Asn Gly Tyr Phe Pro 
 465                470                475                480
Ser Val Asn Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile 
                 485                490                495
Arg Tyr Lys Arg Arg Ser Lys 
             500



<210> 8196
<211> 798
<212> DNA
<213> Homo sapiens
<308> BG567904
<400> 8196

gttcaaatt  agacaattt  gtccactat  cttcgttta  atgaatttg  tctcattga  60
ggatacttt  ccactgtga  ttatacaac  atgattcac  cccctgaaa  cccagttat  120
cgttacaaa  gaagatcaa  atgaaaaag  ttgcaagga  cgaatatat  tgattatca  180
tgtaagcca  aaaggcatt  gaagagaat  aagtgtaca  aacaactct  gtagtttac  240
gttttttta  gtgtgtaat  ctaaaagcc  gtttatgat  taggattgt  ttaactgaa  300
ggttctatc  aatataata  catttgaaa  attttctaa  agttatgat  cttatacat  360
tgctttcag  aagttcctt  gtgaaacaa  tgttcaggg  ggatctagg  aattggcag  420
ttctaaata  tataatttc  agatagtaa  tttaagagt  ctcatcgct  ttgccaaat  480
agttcaggg  attcaaatc  tggactagt  ctgcaaggg  acaaaagaa  aaaaatccc  540
gtgagatac  tggaaacca  agtttatta  tatttatct  ggcaattat  tgtgtgtga  600
gatggaagg  tagggaata  tcgaacatc  aaagccttg  ataagagaa  actaattgt  660
gggtatgat  atactcaga  attggagat  ttataggga  aaagaaatc  ttgggaatt  720
taactaaaa  tcactgata  gagaacatt  ggagatcca  ggacatata  ggataagaa  780
ttctaaaat  atggtaat  798



<210> 8197
<211> 503
<212> PRT
<213> Homo sapiens
<308> Q16850
<400> 8197

Met Leu Leu Leu Gly Leu Leu Gln Ala Gly Gly Ser Val Leu Gly Gln 
  1               5                  10                  15
Ala Met Glu Lys Val Thr Gly Gly Asn Leu Leu Ser Met Leu Leu Ile 
             20                  25                  30
Ala Cys Ala Phe Thr Leu Ser Leu Val Tyr Leu Ile Arg Leu Ala Ala 
         35                  40                  45
Gly His Leu Val Gln Leu Pro Ala Gly Val Lys Ser Pro Pro Tyr Ile 
     50                  55                  60
Phe Ser Pro Ile Pro Phe Leu Gly His Ala Ile Ala Phe Gly Lys Ser 
 65                  70                  75                  80
Pro Ile Glu Phe Leu Glu Asn Ala Tyr Glu Lys Tyr Gly Pro Val Phe 
                 85                  90                  95
Ser Phe Thr Met Val Gly Lys Thr Phe Thr Tyr Leu Leu Gly Ser Asp 
             100                105                110
Ala Ala Ala Leu Leu Phe Asn Ser Lys Asn Glu Asp Leu Asn Ala Glu 
         115                120                125
Asp Val Tyr Ser Arg Leu Thr Thr Pro Val Phe Gly Lys Gly Val Ala 
     130                135                140
Tyr Asp Val Pro Asn Pro Val Phe Leu Glu Gln Lys Lys Met Leu Lys 
 145                150                155                160
Ser Gly Leu Asn Ile Ala His Phe Lys Gln His Val Ser Ile Ile Glu 
                 165                170                175
Lys Glu Thr Lys Glu Tyr Phe Glu Ser Trp Gly Glu Ser Gly Glu Lys 
             180                185                190
Asn Val Phe Glu Ala Leu Ser Glu Leu Ile Ile Leu Thr Ala Ser His 
         195                200                205
Cys Leu His Gly Lys Glu Ile Arg Ser Gln Leu Asn Glu Lys Val Ala 
     210                215                220
Gln Leu Tyr Ala Asp Leu Asp Gly Gly Phe Ser His Ala Ala Trp Leu 
 225                230                235                240
Leu Pro Gly Trp Leu Pro Leu Pro Ser Phe Arg Arg Arg Asp Arg Ala 
                 245                250                255
His Arg Glu Ile Lys Asp Ile Phe Tyr Lys Ala Ile Gln Lys Arg Arg 
             260                265                270
Gln Ser Gln Glu Lys Ile Asp Asp Ile Leu Gln Thr Leu Leu Asp Ala 
         275                280                285
Thr Tyr Lys Asp Gly Arg Pro Leu Thr Asp Asp Glu Val Ala Gly Met 
     290                295                300
Leu Ile Gly Leu Leu Leu Ala Gly Gln His Thr Ser Ser Thr Thr Ser 
 305                310                315                320
Ala Trp Met Gly Phe Phe Leu Ala Arg Asp Lys Thr Leu Gln Lys Lys 
                 325                330                335
Cys Tyr Leu Glu Gln Lys Thr Val Cys Gly Glu Asn Leu Pro Pro Leu 
             340                345                350
Thr Tyr Asp Gln Leu Lys Asp Leu Asn Leu Leu Asp Arg Cys Ile Lys 
         355                360                365
Glu Thr Leu Arg Leu Arg Pro Pro Ile Met Ile Met Met Arg Met Ala 
     370                375                380
Arg Thr Pro Gln Thr Val Ala Gly Tyr Thr Ile Pro Pro Gly His Gln 
 385                390                395                400
Val Cys Val Ser Pro Thr Val Asn Gln Arg Leu Lys Asp Ser Trp Val 
                 405                410                415
Glu Arg Leu Asp Phe Asn Pro Asp Arg Tyr Leu Gln Asp Asn Pro Ala 
             420                425                430
Ser Gly Glu Lys Phe Ala Tyr Val Pro Phe Gly Ala Gly Arg His Arg 
         435                440                445
Cys Ile Gly Glu Asn Phe Ala Tyr Val Gln Ile Lys Thr Ile Trp Ser 
     450                455                460
Thr Met Leu Arg Leu Tyr Glu Phe Asp Leu Ile Asp Gly Tyr Phe Pro 
 465                470                475                480
Thr Val Asn Tyr Thr Thr Met Ile His Thr Pro Glu Asn Pro Val Ile 
                 485                490                495
Arg Tyr Lys Arg Arg Ser Lys 
             500



<210> 8198
<211> 2446
<212> DNA
<213> Rattus norvegicus
<308> U17834
<400> 8198

ccaggagtg  gcagctgct  ccggttggc  ctgacggac  gacaaaccg  cagcctgac  60
tcctagtcc  ccaactaac  agcctgtac  tggctgctt  cccctcccc  ggaacattg  120
ccatgcgtc  cctgtggct  ctcaccttg  tgctggctc  gagccaggc  ttgcccttt  180
agcagaagg  cttctggga  ttcaccttg  atgatgggc  gctcatgat  aatgatgag  240
aggcttcag  ctcagacac  acttcaggt  tccctgacc  ggactctct  acacctacc  300
tcagtgcca  gtgtccttt  ggctgccac  gccacctgc  ggttgttca  tgctctgac  360
tgggtctga  gactgtgcc  aaggagatc  cacctgata  cacactgct  gacctgcag  420
acaatgaca  ctctgaact  cgcaaggat  acttcaaag  cctccagca  ctctatgct  480
tggtcctgg  aaacaataa  atctccaag  tccatgaga  ggcctttag  cctctgcgg  540
agctgcaga  actctacat  tccaagaac  acctggtgg  gattcctcc  aacctgccc  600
gctccctgg  agagctacg  atccatgac  accgtatcc  caaagtgcc  aagggcgtg  660
tcagtgggc  ccggaacat  aactgcatt  agatgggtg  gaatcccct  gagaacagt  720
gctttgaac  cggagcctt  gatggcctg  agctcaact  cctgcgcat  tcagaggcc  780
agctcactg  catccccaa  gatctccct  agaccctga  tgaacttca  ttggaccac  840
acaaaatcc  ggctatcga  ttggaggat  tacttcgct  ctccaagct  tacaggctg  900
gcttaggac  caatcagat  cgaatgatt  agaatggga  cctgagttt  ctgcctacc  960
tgagggaac  tcacttgga  aacaacaag  tgtcccggg  gcctgctgg  ctcccagat  1020
tcaaactcc  ccaggttgt  tatctgcac  ccaacaaca  caccaaggt  ggcatcaac  1080
atttctgcc  catgggctt  ggagtcaag  gggcctact  taatggcat  agcctcttc  1140
acaaccctg  gccctactg  gaagtgcag  ctgccacct  ccgctgcgt  actgaccgc  1200
tggccatcc  atttggaaa  tataagaag  agaagcagt  gtagccacc  tggctcgtt  1260
gtgagagtc  ctgaggaac  tagccagtt  ttccacagg  gaaggggaa  aaagaagca  1320
cacctttgt  ccccaatat  aactcactg  ccaccacag  ttcctctgg  tcctaagca  1380
gcacatatg  acatggcct  gcctctccc  ttcccctca  cctttgaga  ttaacactc  1440
cccaccatg  ccactcaga  actccctat  aatcttttt  cttgctcat  ctgaaactc  1500
gatgtttgt  ggaagaatg  acagagcac  tggccacag  tactgttcc  tccgggcat  1560
tattcctcc  cttccttac  catgtctga  ttctagctc  cctgggctc  gctgctgcc  1620
ttatcctct  gtgatctct  ttcaacaag  tcactacct  tccatccaa  ccgccacct  1680
gctctacta  ctcctggat  cttccctct  tccaactct  ttatgcttc  tggcacttt  1740
cttccttct  gggttatag  tctgtccct  ccatctctg  acctggttc  tatctttct  1800
tctttgtct  tttctgtat  tctttgcct  tatctctgt  tgtctctat  tctgtttct  1860
tctctctgt  tttatatct  cctctctct  tctctctct  tctctctct  tctctctct  1920
tctctcaca  acacacaca  acacacaca  acacacaaa  acaaacaca  acacacaca  1980
acacacaca  acacacaca  acacacaca  acacacacc  tcttctcca  gctgctttc  2040
gtttcacag  tctctggcc  gtccctgca  aaacaaata  agggaaact  ttttcctga  2100
tgccctacc  ggcacttga  ctcccatcc  tggaggaag  tggaagctg  aggcccaga  2160
tcctatcca  attgtccag  aaagggtcc  tactctgtt  tcaagatga  gatcaggaa  2220
cttcctagc  cctggagag  ctcagcagg  caccagagg  ccccacccc  aaccagttt  2280
cattggccc  tgccctctc  ccaagatgg  taggtcccc  ccctcaccc  tgggtccct  2340
ctgtggcag  aggtggtgg  cagttgtac  cagcaggag  gagtgctgc  tatgaggtc  2400
gttgtctct  aattaaaga  acactgtgc  ataaaaaaa  aaaaaa  2446



<210> 8199
<211> 369
<212> PRT
<213> Rattus norvegicus
<308> P47853
<400> 8199

Met Arg Pro Leu Trp Leu Leu Thr Leu Leu Leu Ala Leu Ser Gln Ala 
  1               5                  10                  15
Leu Pro Phe Glu Gln Lys Gly Phe Trp Asp Phe Thr Leu Asp Asp Gly 
             20                  25                  30
Leu Leu Met Met Asn Asp Glu Glu Ala Ser Gly Ser Asp Thr Thr Ser 
         35                  40                  45
Gly Val Pro Asp Leu Asp Ser Leu Thr Pro Thr Phe Ser Ala Met Cys 
     50                  55                  60
Pro Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu 
 65                  70                  75                  80
Gly Leu Lys Thr Val Pro Lys Glu Ile Ser Pro Asp Thr Thr Leu Leu 
                 85                  90                  95
Asp Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp Phe Lys 
             100                105                110
Gly Leu Gln His Leu Tyr Ala Leu Val Leu Val Asn Asn Lys Ile Ser 
         115                120                125
Lys Ile His Glu Lys Ala Phe Ser Pro Leu Arg Lys Leu Gln Lys Leu 
     130                135                140
Tyr Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro Ser 
 145                150                155                160
Ser Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro 
                 165                170                175
Lys Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly 
             180                185                190
Gly Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly 
         195                200                205
Leu Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Thr Gly Ile 
     210                215                220
Pro Lys Asp Leu Pro Glu Thr Leu Asn Glu Leu His Leu Asp His Asn 
 225                230                235                240
Lys Ile Gln Ala Ile Glu Leu Glu Asp Leu Leu Arg Tyr Ser Lys Leu 
                 245                250                255
Tyr Arg Leu Gly Leu Gly His Asn Gln Ile Arg Met Ile Glu Asn Gly 
             260                265                270
Ser Leu Ser Phe Leu Pro Thr Leu Arg Glu Leu His Leu Asp Asn Asn 
         275                280                285
Lys Leu Ser Arg Val Pro Ala Gly Leu Pro Asp Leu Lys Leu Leu Gln 
     290                295                300
Val Val Tyr Leu His Ser Asn Asn Ile Thr Lys Val Gly Ile Asn Asp 
 305                310                315                320
Phe Cys Pro Met Gly Phe Gly Val Lys Arg Ala Tyr Tyr Asn Gly Ile 
                 325                330                335
Ser Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu Val Gln Pro Ala Thr 
             340                345                350
Phe Arg Cys Val Thr Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys 
         355                360                365
Lys 
     370



<210> 8200
<211> 875
<212> DNA
<213> Homo sapiens
<308> BC001754
<400> 8200

cgggattcg  atgggggcg  gtgggggac  ctgcagctg  ggccatttg  ggggagccc  60
tggggcctg  aaggcatct  tcaggcgcc  ctgcccgga  ggcaacagt  gttctagga  120
gagacacca  gggccctga  cgtatcttc  ccaatcaga  tgaggaact  ggacatcag  180
gcccttcag  aggcactgg  gattggagc  gtgaggagc  tgaggaaga  caggaggaa  240
cggggtcgg  cccagctgg  tactcctac  agcccctga  ccaagatcc  gaacaagag  300
aggtggaac  ggcaccagt  ggggatgga  atgtagttg  tgacatcca  gatcgaatc  360
aggccctgg  gcttcattt  ccagaccca  cattagaga  tgaagatga  gatgaggag  420
gagctacag  gttgaacaa  cacagctct  ttcccatgg  cccagaaca  gtagagctg  480
tgaaaagga  aatggctgg  gtaagcctg  ctgcgccag  ggttcctgc  tgggctcgg  540
agatatcgg  tgcccagtg  gaagatgtg  tacagaaag  cctccaagc  cggcaggca  600
cccctgcct  gaagtgacc  cagtgagag  tgccttata  tcctacatt  caggccaga  660
ccagcacag  actgaacac  tccctggtt  taatgtcca  ttccatctt  cccgtctcc  720
tttccacat  aaggcacat  agacttctc  gagacccac  ttattcagt  ctgtacata  780
ggggacatc  gtccaagcc  aacccacct  agcatgtat  actctgtgg  gaataaagc  840
ccctatgta  acaaaaaaa  aaaaaaaaa  aaaaa  875



<210> 8201
<211> 172
<212> PRT
<213> Homo sapiens
<308> Q16626
<400> 8201

Met Ala Thr Val Val Leu Gly Gly Asp Thr Met Gly Pro Glu Arg Ile 
  1               5                  10                  15
Phe Pro Asn Gln Thr Glu Glu Leu Gly His Gln Gly Pro Ser Glu Gly 
             20                  25                  30
Thr Gly Asp Trp Ser Ser Glu Glu Pro Glu Glu Glu Gln Glu Glu Thr 
         35                  40                  45
Gly Ser Gly Pro Ala Gly Tyr Ser Tyr Gln Pro Leu Asn Gln Asp Pro 
     50                  55                  60
Glu Gln Glu Glu Val Glu Leu Ala Pro Val Gly Asp Gly Asp Val Val 
 65                  70                  75                  80
Ala Asp Ile Gln Asp Arg Ile Gln Ala Leu Gly Leu His Leu Pro Asp 
                 85                  90                  95
Pro Pro Leu Glu Ser Glu Asp Glu Asp Glu Glu Gly Ala Thr Ala Leu 
             100                105                110
Asn Asn His Ser Ser Ile Pro Met Asp Pro Glu His Val Glu Leu Val 
         115                120                125
Lys Arg Thr Met Ala Gly Val Ser Leu Pro Ala Pro Gly Val Pro Ala 
     130                135                140
Trp Ala Arg Glu Ile Ser Asp Ala Gln Trp Glu Asp Val Val Gln Lys 
 145                150                155                160
Ala Leu Gln Ala Arg Gln Ala Ser Pro Ala Trp Lys 
                 165                170



<210> 8202
<211> 627
<212> DNA
<213> Rattus norvegicus
<308> U17919
<400> 8202

gaggagcca  ccaacacac  gcagcctca  cgtcatctc  ccacctaag  ccaccagcg  60
ctgaggagc  atgagccag  gcaaggatt  gcagggagg  aaagctttt  gactgctga  120
agcccagca  gaagagagg  tggatggga  caacaagca  ttcctcgat  atcccaagt  180
cagcagtga  gaggatctg  agtccaaac  ggaggcctt  aagacgaag  acatggagt  240
tgatctgaa  ggcaatgga  atatcgata  tatgtcctt  aagcgaatg  tggagaaac  300
tggggttcc  aagacccat  tagagctga  gaaattaat  agagaggtg  ccagtggct  360
cgaggagac  ttcagttac  ctgactttc  cagaatgat  ctgggcaag  gatctgcca  420
cttgagaat  attctgatg  atgaggaga  aaacaaaga  caccagaag  caactggtc  480
cccagccaa  aaagctatt  ctgagttgc  ctaattgga  gtggatata  cacggtggg  540
ccgaggacc  tctaatgac  gcagcatgg  aaaagaaga  gcagttgtg  gccagagtc  600
aactaaata  ataatgctc  ctagtgc  627



<210> 8203
<211> 147
<212> PRT
<213> Rattus norvegicus
<308> P55009
<400> 8203

Met Ser Gln Ser Lys Asp Leu Gln Gly Gly Lys Ala Phe Gly Leu Leu 
  1               5                  10                  15
Lys Ala Gln Gln Glu Glu Arg Leu Asp Gly Ile Asn Lys His Phe Leu 
             20                  25                  30
Asp Asp Pro Lys Tyr Ser Ser Asp Glu Asp Leu Gln Ser Lys Leu Glu 
         35                  40                  45
Ala Phe Lys Thr Lys Tyr Met Glu Phe Asp Leu Asn Gly Asn Gly Asp 
     50                  55                  60
Ile Asp Ile Met Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro 
 65                  70                  75                  80
Lys Thr His Leu Glu Leu Lys Lys Leu Ile Arg Glu Val Ser Ser Gly 
                 85                  90                  95
Ser Glu Glu Thr Phe Ser Tyr Ser Asp Phe Leu Arg Met Met Leu Gly 
             100                105                110
Lys Arg Ser Ala Ile Leu Arg Met Ile Leu Met Tyr Glu Glu Lys Asn 
         115                120                125
Lys Glu His Gln Lys Pro Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser 
     130                135                140
Glu Leu Pro 
 145



<210> 8204
<211> 1235
<212> DNA
<213> Homo sapiens
<308> U95213
<400> 8204

gaggaaaag  tttcggact  ctgaaggcc  agcaggaag  gaggctgga  gagatcaac  60
aggcaattc  tagacgatc  caaatatag  agtgatgag  atctgccct  caaactgga  120
ggcttcaaa  gtgaggggg  aactgtagg  ggtggagac  gggctgggg  taggagggt  180
aggatttcc  caagaacaa  gcaggaaca  cagagataa  aagtttact  ttgtggtag  240
aaaagggga  cctgccttt  ttgccctcc  gccacactg  ggtcccttt  ccgggcctg  300
ctctctcag  atcccctct  gctccttac  acctagcgg  gccctcaac  cccaacccc  360
cttcctctg  ctgcccctc  tcctccttc  acgttgtct  ctccaccta  cagttggtt  420
gcaacccct  cctcacctc  cccagagaa  tacatggag  ttgacctta  tggaaatgg  480
gatattggt  agaaacggg  gatttgcgg  ggcagggtg  tgtgcaggc  taagaagac  540
gaggtctct  ctacatgct  cattcctca  gatttggga  ggggcccac  taccacagt  600
ggaggaagg  gaatgggga  gcggaagtg  gagaggaga  agagggtct  cccaccttc  660
ccccatccc  atcctctgc  cccagatat  atgtccctg  aacgaatgc  ggagaaact  720
ggagtcccc  agactcacc  agagctaaa  aaattaatt  gagaggtgt  cagtggctc  780
ggggagacg  tcagctacc  tgactttct  aggatgatg  tgggcaaga  atctgccat  840
ctaaaaatg  gagtgtcaa  ttccaacct  ccctgtact  acctgtttt  tcctccccc  900
tccctaccc  tgtccacag  ctcaacatt  ctacacgtt  cccatcatc  cttcttcca  960
ccttagagg  acccttcca  ggtcccgac  ccatcccta  ccatagtcc  ggtccccag  1020
aactccaac  cctgccctt  ctcttcccc  ttccaccct  acatcccca  ccccttcta  1080
cctttccta  caccctatg  tttattccc  tgagaggag  gttccctga  ccctgtgcc  1140
cttcccatc  caaccagga  cctgatgta  gaggaaaaa  cgagagaaa  ggaaaagcc  1200
acaggcccc  cagccaaga  agctatctc  gagtt  1235



<210> 8205
<211> 147
<212> PRT
<213> Homo sapiens
<308> P55008
<400> 8205

Met Ser Gln Thr Arg Asp Leu Gln Gly Gly Lys Ala Phe Gly Leu Leu 
  1               5                  10                  15
Lys Ala Gln Gln Glu Glu Arg Leu Asp Glu Ile Asn Lys Gln Phe Leu 
             20                  25                  30
Asp Asp Pro Lys Tyr Ser Ser Asp Glu Asp Leu Pro Ser Lys Leu Glu 
         35                  40                  45
Gly Phe Lys Glu Lys Tyr Met Glu Phe Asp Leu Asn Gly Asn Gly Asp 
     50                  55                  60
Ile Asp Ile Met Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro 
 65                  70                  75                  80
Lys Thr His Leu Glu Leu Lys Lys Leu Ile Gly Glu Val Ser Ser Gly 
                 85                  90                  95
Ser Gly Glu Thr Phe Ser Tyr Pro Asp Phe Leu Arg Met Met Leu Gly 
             100                105                110
Lys Arg Ser Ala Ile Leu Lys Met Ile Leu Met Tyr Glu Glu Lys Ala 
         115                120                125
Arg Glu Lys Glu Lys Pro Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser 
     130                135                140
Glu Leu Pro 
 145



<210> 8206
<211> 1098
<212> DNA
<213> Rattus norvegicus
<308> U18771
<400> 8206

gatagtgaa  tcgtgttgc  ttcaaggtc  tgctggtgg  ggattccgg  gtggggaag  60
cgtgcctgc  cgtgcgctt  aaggatggg  ccttcctgg  tggtacctt  atctccact  120
tgggcatcg  cttccggaa  aaagttctg  atgtggatg  catgaaggt  aagctgcag  180
tctgggaca  ggctggtca  gagcggttc  gaagtgtca  ccatgccta  taccgggat  240
ctcacgcac  gttgctgct  tacgacatc  ccaacaaag  ttccttcga  aacatccag  300
cctggttga  agaaatcca  gaatatgcc  agcaggacg  ggtgctcat  ctgttgggg  360
acaaggttg  ctctactca  gaacgagtg  taaagaggg  agatgggga  aaattagcc  420
aggagtatg  gctgccatt  atggagacc  gcgccaaga  cggcctcaa  gtggacttg  480
cttttacag  catagcaaa  gagctgaaa  aaagatcca  caaggctcc  agtgagccg  540
gcttcaggc  gcatgacta  gtgaagagg  agggccgag  ggtctcctg  tgtcgactc  600
gaacctagc  gaatttcgg  tctacgctg  aggcagctg  ttgggatac  ataggtgat  660
gatgccaga  tgtcttcct  ttcaagaca  ctgaggctg  tgctcttca  ccccttggc  720
tcaggggcc  tcacagaaa  catacaaac  acactatgg  ctgtggctg  cctcttctg  780
gcactccca  caggaagga  ggcaccaca  tcgtgcctc  tatgaaaag  catgcttac  840
gcacacggc  tgggaagga  cccacacac  accaaaggc  acaagaatc  tgttgtcca  900
ttgttgggt  gcttccaag  caactagta  gctctgatg  aggaaacca  aggaagatt  960
ggctgatag  accaggtca  tacttagca  gctggccca  tccttccca  cttgtacta  1020
agtcaccag  ctacaaatg  tgtgtgaaa  cctgtcccc  ttaataaag  tgtttctgc  1080
cgggaattc  cggtcacc  1098



<210> 8207
<211> 190
<212> PRT
<213> Rattus norvegicus
<308> P51156
<400> 8207

Met Leu Val Gly Asp Ser Gly Val Gly Lys Thr Cys Leu Leu Val Arg 
  1               5                  10                  15
Phe Lys Asp Gly Ala Phe Leu Ala Gly Thr Phe Ile Ser Thr Val Gly 
             20                  25                  30
Ile Asp Phe Arg Asn Lys Val Leu Asp Val Asp Gly Met Lys Val Lys 
         35                  40                  45
Leu Gln Ile Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Val Thr 
     50                  55                  60
His Ala Tyr Tyr Arg Asp Ala His Ala Leu Leu Leu Leu Tyr Asp Ile 
 65                  70                  75                  80
Thr Asn Lys Asp Ser Phe Asp Asn Ile Gln Ala Trp Leu Thr Glu Ile 
                 85                  90                  95
Gln Glu Tyr Ala Gln Gln Asp Val Val Leu Met Leu Leu Gly Asn Lys 
             100                105                110
Val Asp Ser Thr Gln Glu Arg Val Val Lys Arg Glu Asp Gly Glu Lys 
         115                120                125
Leu Ala Lys Glu Tyr Gly Leu Pro Phe Met Glu Thr Ser Ala Lys Ser 
     130                135                140
Gly Leu Asn Val Asp Leu Ala Phe Thr Ala Ile Ala Lys Glu Leu Lys 
 145                150                155                160
Gln Arg Ser Thr Lys Ala Pro Ser Glu Pro Arg Phe Arg Leu His Asp 
                 165                170                175
Tyr Val Lys Arg Glu Gly Arg Gly Val Ser Cys Cys Arg Leu 
             180                185                190



<210> 8208
<211> 1513
<212> DNA
<213> Homo sapiens
<308> BC007681
<400> 8208

ggcacgagg  aagagcaaa  gggccagca  ccccgctgc  tccacgctg  ccaccgcca  60
cggggcccg  ccggcgcgc  ccgggactg  gctttccgg  cccgacgcg  cgcccaacg  120
gccttgcag  ccggccggc  ctcgcttgg  ggcggtgtc  acttctacg  cgtcgcctt  180
aaggtcatg  tggtggggg  ctcgggtgt  gggaagacc  gtctgctgg  gcgattcaa  240
gatggtgct  tcctggcgg  gaccttcat  tccaccgta  gcattgact  ccggaacaa  300
gttctggac  tggatggtg  gaaggtgaa  ctgcagatg  gggacacag  tggtcagga  360
cggttccgc  gtgttaccc  tgcctacta  cgggatgct  atgctctgc  gctgctcta  420
gatgtcacc  acaaggcct  ctttgacaa  atccaggcc  ggctgaccg  gatccacga  480
tacgcccag  acgacgtgg  gctcatgct  ctggggaac  aggtggact  tgcccatga  540
cgtgtggtg  agagggagg  cggggagaa  ctggccaag  agtatggac  gcccttcat  600
gagaccagc  ccaagacgg  cctcaacgt  gacttggcc  tcacagcca  agcaaagga  660
ttgaagcag  gctccatga  ggctcccag  gagccgcgc  tccggctgc  tgattacgt  720
aagagggag  gtcgagggg  ctcctgctg  cgcccttga  cctggctga  ctcagtcct  780
tggaggaag  cgcccagtc  ctagaaggc  ggacagagg  tctccaggc  cttctgact  840
tgttgccca  tggccaacg  ccgagtgtc  gttttcagg  gccccaggt  aagccttgt  900
ccttcctcc  cccagcaac  gtcccaaca  gcaggcttc  gagagcccg  ggccgcaca  960
tggccgcca  ggaaaagca  tcttctgca  gggacgggg  gcggcaagt  gacagactt  1020
gccacggtg  tctgctgcc  cctcctggg  acgtccagg  gagggaggg  tggggctgg  1080
accacgcac  gtgcctaac  ctagaaaag  catgtcttc  gccgcacat  ctcaggcag  1140
taagggagg  cgcctgccc  cgcctggga  agaaggctt  actgctaat  acatcgtgc  1200
tctgtgtgt  ctgggagct  cctgctccc  gcccaccct  taggaggct  tggctcaaa  1260
agcaatagg  tcttcctca  tgaccttgg  ggatgcctg  ggccttgtg  taaaatgtg  1320
gaaatcaca  aaaacacca  aaacaacaa  tgccagccc  gcctggcca  aggtgaggt  1380
tgtgatttc  gagcacgct  caccttgca  tcaacttgg  cttttgatt  cacaagcct  1440
tgttttcag  cctagtgaa  aaagttgtg  tttctggaa  aaaaaaaaa  aaaaaaaaa  1500
aaaaaaaaa  aaa  1513



<210> 8209
<211> 190
<212> PRT
<213> Homo sapiens
<308> Q9ULW5
<400> 8209

Met Leu Val Gly Asp Ser Gly Val Gly Lys Thr Cys Leu Leu Val Arg 
  1               5                  10                  15
Phe Lys Asp Gly Ala Phe Leu Ala Gly Thr Phe Ile Ser Thr Val Gly 
             20                  25                  30
Ile Asp Phe Arg Asn Lys Val Leu Asp Val Asp Gly Val Lys Val Lys 
         35                  40                  45
Leu Gln Met Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Val Thr 
     50                  55                  60
His Ala Tyr Tyr Arg Asp Ala His Ala Leu Leu Leu Leu Tyr Asp Val 
 65                  70                  75                  80
Thr Asn Lys Ala Ser Phe Asp Asn Ile Gln Ala Trp Leu Thr Glu Ile 
                 85                  90                  95
His Glu Tyr Ala Gln His Asp Val Ala Leu Met Leu Leu Gly Asn Lys 
             100                105                110
Val Asp Ser Ala His Glu Arg Val Val Lys Arg Glu Asp Gly Glu Lys 
         115                120                125
Leu Ala Lys Glu Tyr Gly Leu Pro Phe Met Glu Thr Ser Ala Lys Thr 
     130                135                140
Gly Leu Asn Val Asp Leu Ala Phe Thr Ala Ile Ala Lys Glu Leu Lys 
 145                150                155                160
Gln Arg Ser Met Lys Ala Pro Ser Glu Pro Arg Phe Arg Leu His Asp 
                 165                170                175
Tyr Val Lys Arg Glu Gly Arg Gly Ala Ser Cys Cys Arg Pro 
             180                185                190



<210> 8210
<211> 2310
<212> DNA
<213> Rattus norvegicus
<308> U19614
<400> 8210

tagaatcga  ccgcggaaa  tccatcgtc  ctatcgacc  acagctacg  aaacaacta  60
ggcgggaga  aggtggcgg  ccgaggggc  gggagaagg  tgggccatc  acgtcacac  120
cagagcccc  atccgggag  gaaggcgga  gctcgccac  caaaatggc  acgggagtg  180
cgcgcctgc  tacgaaact  atccgtcgc  ccacggacg  cgggaagtg  ggttttcag  240
agagccgcc  gaagtgtac  gcgacttcg  gccccgggc  gccaaagaa  ggtctccgg  300
ggaaagacg  accccgcca  aaaagttcc  gtcggattc  gcgaaagag  aagtgagag  360
aagcgctta  aatcttcgg  ctcgacaac  gaggcagcg  ggaccccag  aagccgagg  420
gatgaagac  cggaggtct  ctcgtctgg  gcagcactc  cagcaggcg  agcagcagc  480
gtcaccggc  acgagcggg  gaggattac  ggacgctca  tccttaagt  aggaccgcg  540
agaggatga  ccttcttcc  aacctgtta  aagccaaac  gtctcaaag  aaactgtca  600
gacaccaga  acttcagtg  tgagtgaag  tcctatcag  aacttatgc  gacccccat  660
aagaagccc  agacctgac  cttccattg  ccaacacat  aaccccttt  aggaagatg  720
agccgcagt  gcagccggt  accatccag  ctcactgtg  gggttacca  acagtcggg  780
ggacttcac  gctcatgag  atcaaccct  actgctgcc  acaggatgt  aaaaaaacc  840
tcaagagtg  gttgaacaa  ctgtgagaa  gaggactag  atggcatat  acaacattc  900
gaaatcaga  tttggaaac  aatctccat  aacctccag  caacaagca  ctgtacaac  960
cccagatga  tcttctgtc  agataaaat  gtggctgct  atacttgtt  ctgctctgg  1020
catgggaat  tattggttc  ttcatactc  tgtagtaga  atcactgca  ctcaggatg  1080
tgcggaagt  ctcaagtgt  tgagtgaac  gatcgccga  gcctactct  ccttccgca  1140
tgtccgtgc  atccggatc  acggagcag  caaagctgc  caagacagt  acctcgtta  1200
gcacgaagt  gatcaggaa  tgacagatg  atttagaaa  ggccagaat  cagctgtgg  1260
ccaccgctt  gaatccctg  ctgcaggct  aaccttgat  ttctataaa  actgtgacc  1320
tgaaaacgc  gccttcaaa  atgtggccc  cgtcttgac  gtactgttg  aggagcaga  1380
gctggaagc  agtctaggc  taaaggaaa  tgaggagaa  gtgagggat  tccttaaag  1440
caagttcac  agctctgac  cggccaact  ctacaacca  atggaccca  acaagctca  1500
tggactctg  agccgcatc  cccacctcg  gctgcccgt  cagcctgag  atgctctga  1560
agcaggcag  tgcttatga  ggaaagaag  ggaaatcct  tctcgagtt  gaaccattt  1620
cagactttg  aaccagaga  ggattttgg  gcagttttt  aaaactggt  tctttttaa  1680
ggaagtaaa  ttcatacat  aaggtggaa  aactaaatc  tttatgcag  ctacttctc  1740
gtgatttgg  agaatcgtt  ttctatttc  acctagaac  atgttaaag  tatttagca  1800
agtgcacag  atatgcagt  cccgagtgt  tgctacctt  attctggcc  aatcattct  1860
gctgtgtga  cagcgagaa  ggctaggtt  ctctctcaa  caatcagct  tctattgaa  1920
tttggattt  tgtttgtga  cttattaat  tctgacaac  ccctaattg  agctatgga  1980
ttccctgtt  cttcttctc  cataccatt  aaatgtgtg  tccttagtt  ctacctata  2040
aaataaaac  gggtgtgca  tttagccag  ccctccccc  ctggtttgt  gagagggag  2100
caagggtgt  ggaggtaga  agagaagag  aattgttta  tagggaagg  aaggaagga  2160
ggtaaaaag  tgttgcaag  tgggcatgg  aagccagcc  gttatccca  tattgtccc  2220
gtagtcagg  ggagcagag  ttcaaggtc  gcctcatct  tagagtgag  tttctgcca  2280
ctggactac  tgagacact  tcttaaaaac  2310



<210> 8211
<211> 507
<212> PRT
<213> Rattus norvegicus
<308> U19614
<400> 8211

Met Ala Gly Glu Arg Trp Arg Ala Glu Gly Leu Gly Glu Gly Trp Ala 
  1               5                  10                  15
Ile Tyr Val Thr Pro Arg Ala Pro Ile Arg Glu Gly Arg Arg Arg Leu 
             20                  25                  30
Ala Thr Gln Asn Gly Asp Gly Ser Asp Ala Pro Ala Tyr Glu Thr His 
         35                  40                  45
Pro Ser Arg His Gly Arg Arg Glu Val Arg Phe Ser Glu Glu Pro Pro 
     50                  55                  60
Glu Val Tyr Gly Asp Phe Glu Pro Arg Ala Ala Lys Glu Arg Ser Pro 
 65                  70                  75                  80
Gly Glu Arg Arg Thr Pro Pro Glu Lys Phe Arg Ser Asp Ser Ala Lys 
                 85                  90                  95
Glu Glu Val Arg Glu Ser Ala Tyr Asn Leu Arg Ser Arg Gln Arg Arg 
             100                105                110
Gln Arg Gly Pro Gln Glu Ala Glu Glu Met Lys Thr Arg Arg Ser Thr 
         115                120                125
Arg Leu Glu Gln His Ser Gln Gln Ala Gln Gln Gln Leu Ser Pro Ala 
     130                135                140
Thr Ser Gly Arg Gly Leu Arg Asp Ala Gln Ser Leu Ser Glu Asp Arg 
 145                150                155                160
Gly Glu Asp Glu Pro Ser Ser Gln Pro Val Thr Ser Gln Thr Val Ser 
                 165                170                175
Lys Lys Thr Val Arg Thr Pro Glu Thr Ser Val Met Ser Glu Asp Pro 
             180                185                190
Ile Ser Asn Leu Cys Arg Pro Pro Leu Arg Ser Pro Arg Pro Asp Ala 
         195                200                205
Ser Ile Val Gln His Ile Asn Pro Phe Glu Glu Asp Glu Ala Ala Val 
     210                215                220
Ala Ala Gly His His Pro Asp Ser Leu Trp Gly Leu Pro His Ser Arg 
 225                230                235                240
Gly Asp Phe Thr Ala His Glu Asn Gln Pro Ser Leu Leu Pro Thr Gly 
                 245                250                255
Cys Gln Lys Asn Pro Gln Glu Trp Val Glu Gln Ala Val Arg Met Arg 
             260                265                270
Thr Arg Met Ala Tyr Asn Asn Ile Gln Lys Ser Asp Phe Gly Asn Gln 
         275                280                285
Ser Pro Ser Thr Ser Arg Gln Gln Ala Ala Val Gln Pro Pro Asp Glu 
     290                295                300
Ser Ser Val Lys Ile Lys Trp Trp Leu Leu Ile Leu Val Ala Ala Leu 
 305                310                315                320
Ala Met Gly Ile Tyr Trp Phe Phe His Thr Pro Val Val Glu Ile Thr 
                 325                330                335
Ala Ala Gln Asp Ala Ala Glu Val Leu Lys Cys Leu Ser Glu Gln Ile 
             340                345                350
Ala Asp Ala Tyr Ser Ser Phe Arg Ser Val Arg Ala Ile Arg Ile Asp 
         355                360                365
Gly Ala Gly Lys Ala Ala Gln Asp Ser Asp Leu Val Lys His Glu Val 
     370                375                380
Asp Gln Glu Leu Thr Asp Gly Phe Arg Asn Gly Gln Asn Ala Ala Val 
 385                390                395                400
Val His Arg Phe Glu Ser Leu Pro Ala Gly Ser Thr Leu Ile Phe Tyr 
                 405                410                415
Lys Tyr Cys Asp His Glu Asn Ala Ala Phe Lys Asp Val Ala Leu Val 
             420                425                430
Leu Thr Val Leu Leu Glu Glu Gln Thr Leu Glu Ala Ser Leu Gly Leu 
         435                440                445
Lys Glu Ile Glu Glu Lys Val Arg Asp Phe Leu Lys Val Lys Phe Thr 
     450                455                460
Ser Ser Asp Thr Ala Asn Ser Tyr Asn His Met Asp Pro Asp Lys Leu 
 465                470                475                480
Asn Gly Leu Trp Ser Arg Ile Ser His Leu Val Leu Pro Val Gln Pro 
                 485                490                495
Glu Asn Ala Leu Lys Ala Gly Ser Cys Leu Ter 
             500                505



<210> 8212
<211> 1653
<212> DNA
<213> Homo sapiens
<308> AK021613
<400> 8212

ctagaagag  tccggtccg  ttctgcgaa  gaggaagtg  gagaaagcg  gtactacct  60
cggtctagg  agcggaggc  gccgcgacc  caggaaacc  aggaaatga  gacgcgaag  120
actacccgc  ttcagcagc  gcactcaga  cagcctccg  tacagccgt  tcctgttat  180
accaggaga  ggctgcggg  ctctcattc  tctgaagag  ttgaagcat  ttcccaaac  240
gatttaagc  aaacgatct  aaagaaaac  gtcaggagc  tacaagagg  tccagtgag  300
gaagatctt  taatcaggt  acgtcgacc  cctctaaga  acccaagat  tgaagccac  360
agtgtccaa  agaaggtca  tttctctga  gaaggagaa  ctgaagaag  tgatcaaga  420
agctctcac  gcagtgtca  tactgttaa  gccagatcc  gggattctg  tgaatctgg  480
gataaaacc  ccagatcat  tagtcaata  atagaatca  tttggcagt  atcacaaag  540
caaaacttc  cagctcatg  taagcaacc  tcagtgcta  gctcaggat  tcaaaaaac  600
ccccaggaa  gggccccac  aactgcaag  ataaggacc  ggatgcaaa  tgacagcat  660
ctgaaatca  agcttggaa  ccagtcacc  tcaacctcc  gccgacaag  gactggaca  720
ccccaaaat  catcttttg  caagaggaa  cggtggtgg  tacttcctc  gatagctgc  780
cttgcctct  ggagttttt  gttctttag  actcctgag  tagaaacca  tgctgttca  840
gagttccag  accagatga  tcaacttaa  aataagtac  aaggtcaag  tgagaagct  900
tggaaaagg  gccaaacat  cctggaaaa  catcttaat  gctcccatc  tcggtctca  960
cctgctatc  tactgctca  tgctgcccg  gatgctgaa  aagcactta  gtgtctgag  1020
gaacaaatt  ctgatgcct  ttcttcttt  cgtagtgtc  gtgccatcc  gattgatgg  1080
acagataaa  ctactcaag  cagtgatac  gtcaaacta  aggtagacc  agaactgag  1140
aatgggttt  agaatggcc  gaatgcagc  gtggtacac  gctttgagt  atttcccgc  1200
ggctctact  tgatcttct  caaatattg  gaccatgaa  acgcagcct  caaagatgt  1260
gccttagtc  tgactgtct  attggagga  gagacactt  gaacaagtc  aggcctaaa  1320
gaagttgaa  aaaaagtaa  agattttct  aaagtcaag  tcaccaatt  taacacacc  1380
aactcctac  atcatatgg  cccagacaa  ctgaatggc  tctggagcc  tatttctca  1440
ttagttctg  ctgtgcaac  tgaaaatgc  ctgaaaagg  gcatctgct  ataagaagt  1500
agagagaag  aaaatcatg  cccaagttc  gagaattgt  cacactttc  aaccagaga  1560
agaattcag  gctcttttt  aaagaacta  tttcttttt  aagaagtta  gtgcttaca  1620
aaacatgga  catataaat  attcattca  cct  1653



<210> 8213
<211> 180
<212> PRT
<213> Homo sapiens
<308> CAB43282
<400> 8213

Arg Ser Gln Pro Ala Ile Leu Leu Leu Thr Ala Ala Arg Asp Ala Glu 
  1               5                  10                  15
Glu Ala Leu Arg Cys Leu Ser Glu Gln Ile Ala Asp Ala Tyr Ser Ser 
             20                  25                  30
Phe Arg Ser Val Arg Ala Ile Arg Ile Asp Gly Thr Asp Lys Ala Thr 
         35                  40                  45
Gln Asp Ser Asp Thr Val Lys Leu Glu Val Asp Gln Glu Leu Ser Asn 
     50                  55                  60
Gly Phe Lys Asn Gly Gln Asn Ala Ala Val Val His Arg Phe Glu Ser 
 65                  70                  75                  80
Phe Pro Ala Gly Ser Thr Leu Ile Phe Tyr Lys Tyr Cys Asp His Glu 
                 85                  90                  95
Asn Ala Ala Phe Lys Asp Val Ala Leu Val Leu Thr Val Leu Leu Glu 
             100                105                110
Glu Glu Thr Leu Gly Thr Ser Leu Gly Leu Lys Glu Val Glu Glu Lys 
         115                120                125
Val Arg Asp Phe Leu Lys Val Lys Phe Thr Asn Ser Asn Thr Pro Asn 
     130                135                140
Ser Tyr Asn His Met Asp Pro Asp Lys Leu Asn Gly Leu Trp Ser Arg 
 145                150                155                160
Ile Ser His Leu Val Leu Pro Val Gln Pro Glu Asn Ala Leu Lys Arg 
                 165                170                175
Gly Ile Cys Leu 
             180



<210> 8214
<211> 2310
<212> DNA
<213> Rattus norvegicus
<308> U19614
<400> 8214

tagaatcga  ccgcggaaa  tccatcgtc  ctatcgacc  acagctacg  aaacaacta  60
ggcgggaga  aggtggcgg  ccgaggggc  gggagaagg  tgggccatc  acgtcacac  120
cagagcccc  atccgggag  gaaggcgga  gctcgccac  caaaatggc  acgggagtg  180
cgcgcctgc  tacgaaact  atccgtcgc  ccacggacg  cgggaagtg  ggttttcag  240
agagccgcc  gaagtgtac  gcgacttcg  gccccgggc  gccaaagaa  ggtctccgg  300
ggaaagacg  accccgcca  aaaagttcc  gtcggattc  gcgaaagag  aagtgagag  360
aagcgctta  aatcttcgg  ctcgacaac  gaggcagcg  ggaccccag  aagccgagg  420
gatgaagac  cggaggtct  ctcgtctgg  gcagcactc  cagcaggcg  agcagcagc  480
gtcaccggc  acgagcggg  gaggattac  ggacgctca  tccttaagt  aggaccgcg  540
agaggatga  ccttcttcc  aacctgtta  aagccaaac  gtctcaaag  aaactgtca  600
gacaccaga  acttcagtg  tgagtgaag  tcctatcag  aacttatgc  gacccccat  660
aagaagccc  agacctgac  cttccattg  ccaacacat  aaccccttt  aggaagatg  720
agccgcagt  gcagccggt  accatccag  ctcactgtg  gggttacca  acagtcggg  780
ggacttcac  gctcatgag  atcaaccct  actgctgcc  acaggatgt  aaaaaaacc  840
tcaagagtg  gttgaacaa  ctgtgagaa  gaggactag  atggcatat  acaacattc  900
gaaatcaga  tttggaaac  aatctccat  aacctccag  caacaagca  ctgtacaac  960
cccagatga  tcttctgtc  agataaaat  gtggctgct  atacttgtt  ctgctctgg  1020
catgggaat  tattggttc  ttcatactc  tgtagtaga  atcactgca  ctcaggatg  1080
tgcggaagt  ctcaagtgt  tgagtgaac  gatcgccga  gcctactct  ccttccgca  1140
tgtccgtgc  atccggatc  acggagcag  caaagctgc  caagacagt  acctcgtta  1200
gcacgaagt  gatcaggaa  tgacagatg  atttagaaa  ggccagaat  cagctgtgg  1260
ccaccgctt  gaatccctg  ctgcaggct  aaccttgat  ttctataaa  actgtgacc  1320
tgaaaacgc  gccttcaaa  atgtggccc  cgtcttgac  gtactgttg  aggagcaga  1380
gctggaagc  agtctaggc  taaaggaaa  tgaggagaa  gtgagggat  tccttaaag  1440
caagttcac  agctctgac  cggccaact  ctacaacca  atggaccca  acaagctca  1500
tggactctg  agccgcatc  cccacctcg  gctgcccgt  cagcctgag  atgctctga  1560
agcaggcag  tgcttatga  ggaaagaag  ggaaatcct  tctcgagtt  gaaccattt  1620
cagactttg  aaccagaga  ggattttgg  gcagttttt  aaaactggt  tctttttaa  1680
ggaagtaaa  ttcatacat  aaggtggaa  aactaaatc  tttatgcag  ctacttctc  1740
gtgatttgg  agaatcgtt  ttctatttc  acctagaac  atgttaaag  tatttagca  1800
agtgcacag  atatgcagt  cccgagtgt  tgctacctt  attctggcc  aatcattct  1860
gctgtgtga  cagcgagaa  ggctaggtt  ctctctcaa  caatcagct  tctattgaa  1920
tttggattt  tgtttgtga  cttattaat  tctgacaac  ccctaattg  agctatgga  1980
ttccctgtt  cttcttctc  cataccatt  aaatgtgtg  tccttagtt  ctacctata  2040
aaataaaac  gggtgtgca  tttagccag  ccctccccc  ctggtttgt  gagagggag  2100
caagggtgt  ggaggtaga  agagaagag  aattgttta  tagggaagg  aaggaagga  2160
ggtaaaaag  tgttgcaag  tgggcatgg  aagccagcc  gttatccca  tattgtccc  2220
gtagtcagg  ggagcagag  ttcaaggtc  gcctcatct  tagagtgag  tttctgcca  2280
ctggactac  tgagacact  tcttaaaaac  2310



<210> 8215
<211> 507
<212> PRT
<213> Rattus norvegicus
<308> U19614
<400> 8215

Met Ala Gly Glu Arg Trp Arg Ala Glu Gly Leu Gly Glu Gly Trp Ala 
  1               5                  10                  15
Ile Tyr Val Thr Pro Arg Ala Pro Ile Arg Glu Gly Arg Arg Arg Leu 
             20                  25                  30
Ala Thr Gln Asn Gly Asp Gly Ser Asp Ala Pro Ala Tyr Glu Thr His 
         35                  40                  45
Pro Ser Arg His Gly Arg Arg Glu Val Arg Phe Ser Glu Glu Pro Pro 
     50                  55                  60
Glu Val Tyr Gly Asp Phe Glu Pro Arg Ala Ala Lys Glu Arg Ser Pro 
 65                  70                  75                  80
Gly Glu Arg Arg Thr Pro Pro Glu Lys Phe Arg Ser Asp Ser Ala Lys 
                 85                  90                  95
Glu Glu Val Arg Glu Ser Ala Tyr Asn Leu Arg Ser Arg Gln Arg Arg 
             100                105                110
Gln Arg Gly Pro Gln Glu Ala Glu Glu Met Lys Thr Arg Arg Ser Thr 
         115                120                125
Arg Leu Glu Gln His Ser Gln Gln Ala Gln Gln Gln Leu Ser Pro Ala 
     130                135                140
Thr Ser Gly Arg Gly Leu Arg Asp Ala Gln Ser Leu Ser Glu Asp Arg 
 145                150                155                160
Gly Glu Asp Glu Pro Ser Ser Gln Pro Val Thr Ser Gln Thr Val Ser 
                 165                170                175
Lys Lys Thr Val Arg Thr Pro Glu Thr Ser Val Met Ser Glu Asp Pro 
             180                185                190
Ile Ser Asn Leu Cys Arg Pro Pro Leu Arg Ser Pro Arg Pro Asp Ala 
         195                200                205
Ser Ile Val Gln His Ile Asn Pro Phe Glu Glu Asp Glu Ala Ala Val 
     210                215                220
Ala Ala Gly His His Pro Asp Ser Leu Trp Gly Leu Pro His Ser Arg 
 225                230                235                240
Gly Asp Phe Thr Ala His Glu Asn Gln Pro Ser Leu Leu Pro Thr Gly 
                 245                250                255
Cys Gln Lys Asn Pro Gln Glu Trp Val Glu Gln Ala Val Arg Met Arg 
             260                265                270
Thr Arg Met Ala Tyr Asn Asn Ile Gln Lys Ser Asp Phe Gly Asn Gln 
         275                280                285
Ser Pro Ser Thr Ser Arg Gln Gln Ala Ala Val Gln Pro Pro Asp Glu 
     290                295                300
Ser Ser Val Lys Ile Lys Trp Trp Leu Leu Ile Leu Val Ala Ala Leu 
 305                310                315                320
Ala Met Gly Ile Tyr Trp Phe Phe His Thr Pro Val Val Glu Ile Thr 
                 325                330                335
Ala Ala Gln Asp Ala Ala Glu Val Leu Lys Cys Leu Ser Glu Gln Ile 
             340                345                350
Ala Asp Ala Tyr Ser Ser Phe Arg Ser Val Arg Ala Ile Arg Ile Asp 
         355                360                365
Gly Ala Gly Lys Ala Ala Gln Asp Ser Asp Leu Val Lys His Glu Val 
     370                375                380
Asp Gln Glu Leu Thr Asp Gly Phe Arg Asn Gly Gln Asn Ala Ala Val 
 385                390                395                400
Val His Arg Phe Glu Ser Leu Pro Ala Gly Ser Thr Leu Ile Phe Tyr 
                 405                410                415
Lys Tyr Cys Asp His Glu Asn Ala Ala Phe Lys Asp Val Ala Leu Val 
             420                425                430
Leu Thr Val Leu Leu Glu Glu Gln Thr Leu Glu Ala Ser Leu Gly Leu 
         435                440                445
Lys Glu Ile Glu Glu Lys Val Arg Asp Phe Leu Lys Val Lys Phe Thr 
     450                455                460
Ser Ser Asp Thr Ala Asn Ser Tyr Asn His Met Asp Pro Asp Lys Leu 
 465                470                475                480
Asn Gly Leu Trp Ser Arg Ile Ser His Leu Val Leu Pro Val Gln Pro 
                 485                490                495
Glu Asn Ala Leu Lys Ala Gly Ser Cys Leu Ter 
             500                505



<210> 8216
<211> 1653
<212> DNA
<213> Homo sapiens
<308> AK021613
<400> 8216

ctagaagag  tccggtccg  ttctgcgaa  gaggaagtg  gagaaagcg  gtactacct  60
cggtctagg  agcggaggc  gccgcgacc  caggaaacc  aggaaatga  gacgcgaag  120
actacccgc  ttcagcagc  gcactcaga  cagcctccg  tacagccgt  tcctgttat  180
accaggaga  ggctgcggg  ctctcattc  tctgaagag  ttgaagcat  ttcccaaac  240
gatttaagc  aaacgatct  aaagaaaac  gtcaggagc  tacaagagg  tccagtgag  300
gaagatctt  taatcaggt  acgtcgacc  cctctaaga  acccaagat  tgaagccac  360
agtgtccaa  agaaggtca  tttctctga  gaaggagaa  ctgaagaag  tgatcaaga  420
agctctcac  gcagtgtca  tactgttaa  gccagatcc  gggattctg  tgaatctgg  480
gataaaacc  ccagatcat  tagtcaata  atagaatca  tttggcagt  atcacaaag  540
caaaacttc  cagctcatg  taagcaacc  tcagtgcta  gctcaggat  tcaaaaaac  600
ccccaggaa  gggccccac  aactgcaag  ataaggacc  ggatgcaaa  tgacagcat  660
ctgaaatca  agcttggaa  ccagtcacc  tcaacctcc  gccgacaag  gactggaca  720
ccccaaaat  catcttttg  caagaggaa  cggtggtgg  tacttcctc  gatagctgc  780
cttgcctct  ggagttttt  gttctttag  actcctgag  tagaaacca  tgctgttca  840
gagttccag  accagatga  tcaacttaa  aataagtac  aaggtcaag  tgagaagct  900
tggaaaagg  gccaaacat  cctggaaaa  catcttaat  gctcccatc  tcggtctca  960
cctgctatc  tactgctca  tgctgcccg  gatgctgaa  aagcactta  gtgtctgag  1020
gaacaaatt  ctgatgcct  ttcttcttt  cgtagtgtc  gtgccatcc  gattgatgg  1080
acagataaa  ctactcaag  cagtgatac  gtcaaacta  aggtagacc  agaactgag  1140
aatgggttt  agaatggcc  gaatgcagc  gtggtacac  gctttgagt  atttcccgc  1200
ggctctact  tgatcttct  caaatattg  gaccatgaa  acgcagcct  caaagatgt  1260
gccttagtc  tgactgtct  attggagga  gagacactt  gaacaagtc  aggcctaaa  1320
gaagttgaa  aaaaagtaa  agattttct  aaagtcaag  tcaccaatt  taacacacc  1380
aactcctac  atcatatgg  cccagacaa  ctgaatggc  tctggagcc  tatttctca  1440
ttagttctg  ctgtgcaac  tgaaaatgc  ctgaaaagg  gcatctgct  ataagaagt  1500
agagagaag  aaaatcatg  cccaagttc  gagaattgt  cacactttc  aaccagaga  1560
agaattcag  gctcttttt  aaagaacta  tttcttttt  aagaagtta  gtgcttaca  1620
aaacatgga  catataaat  attcattca  cct  1653



<210> 8217
<211> 180
<212> PRT
<213> Homo sapiens
<308> CAB43282
<400> 8217

Arg Ser Gln Pro Ala Ile Leu Leu Leu Thr Ala Ala Arg Asp Ala Glu 
  1               5                  10                  15
Glu Ala Leu Arg Cys Leu Ser Glu Gln Ile Ala Asp Ala Tyr Ser Ser 
             20                  25                  30
Phe Arg Ser Val Arg Ala Ile Arg Ile Asp Gly Thr Asp Lys Ala Thr 
         35                  40                  45
Gln Asp Ser Asp Thr Val Lys Leu Glu Val Asp Gln Glu Leu Ser Asn 
     50                  55                  60
Gly Phe Lys Asn Gly Gln Asn Ala Ala Val Val His Arg Phe Glu Ser 
 65                  70                  75                  80
Phe Pro Ala Gly Ser Thr Leu Ile Phe Tyr Lys Tyr Cys Asp His Glu 
                 85                  90                  95
Asn Ala Ala Phe Lys Asp Val Ala Leu Val Leu Thr Val Leu Leu Glu 
             100                105                110
Glu Glu Thr Leu Gly Thr Ser Leu Gly Leu Lys Glu Val Glu Glu Lys 
         115                120                125
Val Arg Asp Phe Leu Lys Val Lys Phe Thr Asn Ser Asn Thr Pro Asn 
     130                135                140
Ser Tyr Asn His Met Asp Pro Asp Lys Leu Asn Gly Leu Trp Ser Arg 
 145                150                155                160
Ile Ser His Leu Val Leu Pro Val Gln Pro Glu Asn Ala Leu Lys Arg 
                 165                170                175
Gly Ile Cys Leu 
             180



<210> 8218
<211> 2310
<212> DNA
<213> Rattus norvegicus
<308> U19614
<400> 8218

tagaatcga  ccgcggaaa  tccatcgtc  ctatcgacc  acagctacg  aaacaacta  60
ggcgggaga  aggtggcgg  ccgaggggc  gggagaagg  tgggccatc  acgtcacac  120
cagagcccc  atccgggag  gaaggcgga  gctcgccac  caaaatggc  acgggagtg  180
cgcgcctgc  tacgaaact  atccgtcgc  ccacggacg  cgggaagtg  ggttttcag  240
agagccgcc  gaagtgtac  gcgacttcg  gccccgggc  gccaaagaa  ggtctccgg  300
ggaaagacg  accccgcca  aaaagttcc  gtcggattc  gcgaaagag  aagtgagag  360
aagcgctta  aatcttcgg  ctcgacaac  gaggcagcg  ggaccccag  aagccgagg  420
gatgaagac  cggaggtct  ctcgtctgg  gcagcactc  cagcaggcg  agcagcagc  480
gtcaccggc  acgagcggg  gaggattac  ggacgctca  tccttaagt  aggaccgcg  540
agaggatga  ccttcttcc  aacctgtta  aagccaaac  gtctcaaag  aaactgtca  600
gacaccaga  acttcagtg  tgagtgaag  tcctatcag  aacttatgc  gacccccat  660
aagaagccc  agacctgac  cttccattg  ccaacacat  aaccccttt  aggaagatg  720
agccgcagt  gcagccggt  accatccag  ctcactgtg  gggttacca  acagtcggg  780
ggacttcac  gctcatgag  atcaaccct  actgctgcc  acaggatgt  aaaaaaacc  840
tcaagagtg  gttgaacaa  ctgtgagaa  gaggactag  atggcatat  acaacattc  900
gaaatcaga  tttggaaac  aatctccat  aacctccag  caacaagca  ctgtacaac  960
cccagatga  tcttctgtc  agataaaat  gtggctgct  atacttgtt  ctgctctgg  1020
catgggaat  tattggttc  ttcatactc  tgtagtaga  atcactgca  ctcaggatg  1080
tgcggaagt  ctcaagtgt  tgagtgaac  gatcgccga  gcctactct  ccttccgca  1140
tgtccgtgc  atccggatc  acggagcag  caaagctgc  caagacagt  acctcgtta  1200
gcacgaagt  gatcaggaa  tgacagatg  atttagaaa  ggccagaat  cagctgtgg  1260
ccaccgctt  gaatccctg  ctgcaggct  aaccttgat  ttctataaa  actgtgacc  1320
tgaaaacgc  gccttcaaa  atgtggccc  cgtcttgac  gtactgttg  aggagcaga  1380
gctggaagc  agtctaggc  taaaggaaa  tgaggagaa  gtgagggat  tccttaaag  1440
caagttcac  agctctgac  cggccaact  ctacaacca  atggaccca  acaagctca  1500
tggactctg  agccgcatc  cccacctcg  gctgcccgt  cagcctgag  atgctctga  1560
agcaggcag  tgcttatga  ggaaagaag  ggaaatcct  tctcgagtt  gaaccattt  1620
cagactttg  aaccagaga  ggattttgg  gcagttttt  aaaactggt  tctttttaa  1680
ggaagtaaa  ttcatacat  aaggtggaa  aactaaatc  tttatgcag  ctacttctc  1740
gtgatttgg  agaatcgtt  ttctatttc  acctagaac  atgttaaag  tatttagca  1800
agtgcacag  atatgcagt  cccgagtgt  tgctacctt  attctggcc  aatcattct  1860
gctgtgtga  cagcgagaa  ggctaggtt  ctctctcaa  caatcagct  tctattgaa  1920
tttggattt  tgtttgtga  cttattaat  tctgacaac  ccctaattg  agctatgga  1980
ttccctgtt  cttcttctc  cataccatt  aaatgtgtg  tccttagtt  ctacctata  2040
aaataaaac  gggtgtgca  tttagccag  ccctccccc  ctggtttgt  gagagggag  2100
caagggtgt  ggaggtaga  agagaagag  aattgttta  tagggaagg  aaggaagga  2160
ggtaaaaag  tgttgcaag  tgggcatgg  aagccagcc  gttatccca  tattgtccc  2220
gtagtcagg  ggagcagag  ttcaaggtc  gcctcatct  tagagtgag  tttctgcca  2280
ctggactac  tgagacact  tcttaaaaac  2310



<210> 8219
<211> 507
<212> PRT
<213> Rattus norvegicus
<308> U19614
<400> 8219

Met Ala Gly Glu Arg Trp Arg Ala Glu Gly Leu Gly Glu Gly Trp Ala 
  1               5                  10                  15
Ile Tyr Val Thr Pro Arg Ala Pro Ile Arg Glu Gly Arg Arg Arg Leu 
             20                  25                  30
Ala Thr Gln Asn Gly Asp Gly Ser Asp Ala Pro Ala Tyr Glu Thr His 
         35                  40                  45
Pro Ser Arg His Gly Arg Arg Glu Val Arg Phe Ser Glu Glu Pro Pro 
     50                  55                  60
Glu Val Tyr Gly Asp Phe Glu Pro Arg Ala Ala Lys Glu Arg Ser Pro 
 65                  70                  75                  80
Gly Glu Arg Arg Thr Pro Pro Glu Lys Phe Arg Ser Asp Ser Ala Lys 
                 85                  90                  95
Glu Glu Val Arg Glu Ser Ala Tyr Asn Leu Arg Ser Arg Gln Arg Arg 
             100                105                110
Gln Arg Gly Pro Gln Glu Ala Glu Glu Met Lys Thr Arg Arg Ser Thr 
         115                120                125
Arg Leu Glu Gln His Ser Gln Gln Ala Gln Gln Gln Leu Ser Pro Ala 
     130                135                140
Thr Ser Gly Arg Gly Leu Arg Asp Ala Gln Ser Leu Ser Glu Asp Arg 
 145                150                155                160
Gly Glu Asp Glu Pro Ser Ser Gln Pro Val Thr Ser Gln Thr Val Ser 
                 165                170                175
Lys Lys Thr Val Arg Thr Pro Glu Thr Ser Val Met Ser Glu Asp Pro 
             180                185                190
Ile Ser Asn Leu Cys Arg Pro Pro Leu Arg Ser Pro Arg Pro Asp Ala 
         195                200                205
Ser Ile Val Gln His Ile Asn Pro Phe Glu Glu Asp Glu Ala Ala Val 
     210                215                220
Ala Ala Gly His His Pro Asp Ser Leu Trp Gly Leu Pro His Ser Arg 
 225                230                235                240
Gly Asp Phe Thr Ala His Glu Asn Gln Pro Ser Leu Leu Pro Thr Gly 
                 245                250                255
Cys Gln Lys Asn Pro Gln Glu Trp Val Glu Gln Ala Val Arg Met Arg 
             260                265                270
Thr Arg Met Ala Tyr Asn Asn Ile Gln Lys Ser Asp Phe Gly Asn Gln 
         275                280                285
Ser Pro Ser Thr Ser Arg Gln Gln Ala Ala Val Gln Pro Pro Asp Glu 
     290                295                300
Ser Ser Val Lys Ile Lys Trp Trp Leu Leu Ile Leu Val Ala Ala Leu 
 305                310                315                320
Ala Met Gly Ile Tyr Trp Phe Phe His Thr Pro Val Val Glu Ile Thr 
                 325                330                335
Ala Ala Gln Asp Ala Ala Glu Val Leu Lys Cys Leu Ser Glu Gln Ile 
             340                345                350
Ala Asp Ala Tyr Ser Ser Phe Arg Ser Val Arg Ala Ile Arg Ile Asp 
         355                360                365
Gly Ala Gly Lys Ala Ala Gln Asp Ser Asp Leu Val Lys His Glu Val 
     370                375                380
Asp Gln Glu Leu Thr Asp Gly Phe Arg Asn Gly Gln Asn Ala Ala Val 
 385                390                395                400
Val His Arg Phe Glu Ser Leu Pro Ala Gly Ser Thr Leu Ile Phe Tyr 
                 405                410                415
Lys Tyr Cys Asp His Glu Asn Ala Ala Phe Lys Asp Val Ala Leu Val 
             420                425                430
Leu Thr Val Leu Leu Glu Glu Gln Thr Leu Glu Ala Ser Leu Gly Leu 
         435                440                445
Lys Glu Ile Glu Glu Lys Val Arg Asp Phe Leu Lys Val Lys Phe Thr 
     450                455                460
Ser Ser Asp Thr Ala Asn Ser Tyr Asn His Met Asp Pro Asp Lys Leu 
 465                470                475                480
Asn Gly Leu Trp Ser Arg Ile Ser His Leu Val Leu Pro Val Gln Pro 
                 485                490                495
Glu Asn Ala Leu Lys Ala Gly Ser Cys Leu Ter 
             500                505



<210> 8220
<211> 1653
<212> DNA
<213> Homo sapiens
<308> AK021613
<400> 8220

ctagaagag  tccggtccg  ttctgcgaa  gaggaagtg  gagaaagcg  gtactacct  60
cggtctagg  agcggaggc  gccgcgacc  caggaaacc  aggaaatga  gacgcgaag  120
actacccgc  ttcagcagc  gcactcaga  cagcctccg  tacagccgt  tcctgttat  180
accaggaga  ggctgcggg  ctctcattc  tctgaagag  ttgaagcat  ttcccaaac  240
gatttaagc  aaacgatct  aaagaaaac  gtcaggagc  tacaagagg  tccagtgag  300
gaagatctt  taatcaggt  acgtcgacc  cctctaaga  acccaagat  tgaagccac  360
agtgtccaa  agaaggtca  tttctctga  gaaggagaa  ctgaagaag  tgatcaaga  420
agctctcac  gcagtgtca  tactgttaa  gccagatcc  gggattctg  tgaatctgg  480
gataaaacc  ccagatcat  tagtcaata  atagaatca  tttggcagt  atcacaaag  540
caaaacttc  cagctcatg  taagcaacc  tcagtgcta  gctcaggat  tcaaaaaac  600
ccccaggaa  gggccccac  aactgcaag  ataaggacc  ggatgcaaa  tgacagcat  660
ctgaaatca  agcttggaa  ccagtcacc  tcaacctcc  gccgacaag  gactggaca  720
ccccaaaat  catcttttg  caagaggaa  cggtggtgg  tacttcctc  gatagctgc  780
cttgcctct  ggagttttt  gttctttag  actcctgag  tagaaacca  tgctgttca  840
gagttccag  accagatga  tcaacttaa  aataagtac  aaggtcaag  tgagaagct  900
tggaaaagg  gccaaacat  cctggaaaa  catcttaat  gctcccatc  tcggtctca  960
cctgctatc  tactgctca  tgctgcccg  gatgctgaa  aagcactta  gtgtctgag  1020
gaacaaatt  ctgatgcct  ttcttcttt  cgtagtgtc  gtgccatcc  gattgatgg  1080
acagataaa  ctactcaag  cagtgatac  gtcaaacta  aggtagacc  agaactgag  1140
aatgggttt  agaatggcc  gaatgcagc  gtggtacac  gctttgagt  atttcccgc  1200
ggctctact  tgatcttct  caaatattg  gaccatgaa  acgcagcct  caaagatgt  1260
gccttagtc  tgactgtct  attggagga  gagacactt  gaacaagtc  aggcctaaa  1320
gaagttgaa  aaaaagtaa  agattttct  aaagtcaag  tcaccaatt  taacacacc  1380
aactcctac  atcatatgg  cccagacaa  ctgaatggc  tctggagcc  tatttctca  1440
ttagttctg  ctgtgcaac  tgaaaatgc  ctgaaaagg  gcatctgct  ataagaagt  1500
agagagaag  aaaatcatg  cccaagttc  gagaattgt  cacactttc  aaccagaga  1560
agaattcag  gctcttttt  aaagaacta  tttcttttt  aagaagtta  gtgcttaca  1620
aaacatgga  catataaat  attcattca  cct  1653



<210> 8221
<211> 180
<212> PRT
<213> Homo sapiens
<308> CAB43282
<400> 8221

Arg Ser Gln Pro Ala Ile Leu Leu Leu Thr Ala Ala Arg Asp Ala Glu 
  1               5                  10                  15
Glu Ala Leu Arg Cys Leu Ser Glu Gln Ile Ala Asp Ala Tyr Ser Ser 
             20                  25                  30
Phe Arg Ser Val Arg Ala Ile Arg Ile Asp Gly Thr Asp Lys Ala Thr 
         35                  40                  45
Gln Asp Ser Asp Thr Val Lys Leu Glu Val Asp Gln Glu Leu Ser Asn 
     50                  55                  60
Gly Phe Lys Asn Gly Gln Asn Ala Ala Val Val His Arg Phe Glu Ser 
 65                  70                  75                  80
Phe Pro Ala Gly Ser Thr Leu Ile Phe Tyr Lys Tyr Cys Asp His Glu 
                 85                  90                  95
Asn Ala Ala Phe Lys Asp Val Ala Leu Val Leu Thr Val Leu Leu Glu 
             100                105                110
Glu Glu Thr Leu Gly Thr Ser Leu Gly Leu Lys Glu Val Glu Glu Lys 
         115                120                125
Val Arg Asp Phe Leu Lys Val Lys Phe Thr Asn Ser Asn Thr Pro Asn 
     130                135                140
Ser Tyr Asn His Met Asp Pro Asp Lys Leu Asn Gly Leu Trp Ser Arg 
 145                150                155                160
Ile Ser His Leu Val Leu Pro Val Gln Pro Glu Asn Ala Leu Lys Arg 
                 165                170                175
Gly Ile Cys Leu 
             180



<210> 8222
<211> 2310
<212> DNA
<213> Rattus norvegicus
<308> U19614
<400> 8222

tagaatcga  ccgcggaaa  tccatcgtc  ctatcgacc  acagctacg  aaacaacta  60
ggcgggaga  aggtggcgg  ccgaggggc  gggagaagg  tgggccatc  acgtcacac  120
cagagcccc  atccgggag  gaaggcgga  gctcgccac  caaaatggc  acgggagtg  180
cgcgcctgc  tacgaaact  atccgtcgc  ccacggacg  cgggaagtg  ggttttcag  240
agagccgcc  gaagtgtac  gcgacttcg  gccccgggc  gccaaagaa  ggtctccgg  300
ggaaagacg  accccgcca  aaaagttcc  gtcggattc  gcgaaagag  aagtgagag  360
aagcgctta  aatcttcgg  ctcgacaac  gaggcagcg  ggaccccag  aagccgagg  420
gatgaagac  cggaggtct  ctcgtctgg  gcagcactc  cagcaggcg  agcagcagc  480
gtcaccggc  acgagcggg  gaggattac  ggacgctca  tccttaagt  aggaccgcg  540
agaggatga  ccttcttcc  aacctgtta  aagccaaac  gtctcaaag  aaactgtca  600
gacaccaga  acttcagtg  tgagtgaag  tcctatcag  aacttatgc  gacccccat  660
aagaagccc  agacctgac  cttccattg  ccaacacat  aaccccttt  aggaagatg  720
agccgcagt  gcagccggt  accatccag  ctcactgtg  gggttacca  acagtcggg  780
ggacttcac  gctcatgag  atcaaccct  actgctgcc  acaggatgt  aaaaaaacc  840
tcaagagtg  gttgaacaa  ctgtgagaa  gaggactag  atggcatat  acaacattc  900
gaaatcaga  tttggaaac  aatctccat  aacctccag  caacaagca  ctgtacaac  960
cccagatga  tcttctgtc  agataaaat  gtggctgct  atacttgtt  ctgctctgg  1020
catgggaat  tattggttc  ttcatactc  tgtagtaga  atcactgca  ctcaggatg  1080
tgcggaagt  ctcaagtgt  tgagtgaac  gatcgccga  gcctactct  ccttccgca  1140
tgtccgtgc  atccggatc  acggagcag  caaagctgc  caagacagt  acctcgtta  1200
gcacgaagt  gatcaggaa  tgacagatg  atttagaaa  ggccagaat  cagctgtgg  1260
ccaccgctt  gaatccctg  ctgcaggct  aaccttgat  ttctataaa  actgtgacc  1320
tgaaaacgc  gccttcaaa  atgtggccc  cgtcttgac  gtactgttg  aggagcaga  1380
gctggaagc  agtctaggc  taaaggaaa  tgaggagaa  gtgagggat  tccttaaag  1440
caagttcac  agctctgac  cggccaact  ctacaacca  atggaccca  acaagctca  1500
tggactctg  agccgcatc  cccacctcg  gctgcccgt  cagcctgag  atgctctga  1560
agcaggcag  tgcttatga  ggaaagaag  ggaaatcct  tctcgagtt  gaaccattt  1620
cagactttg  aaccagaga  ggattttgg  gcagttttt  aaaactggt  tctttttaa  1680
ggaagtaaa  ttcatacat  aaggtggaa  aactaaatc  tttatgcag  ctacttctc  1740
gtgatttgg  agaatcgtt  ttctatttc  acctagaac  atgttaaag  tatttagca  1800
agtgcacag  atatgcagt  cccgagtgt  tgctacctt  attctggcc  aatcattct  1860
gctgtgtga  cagcgagaa  ggctaggtt  ctctctcaa  caatcagct  tctattgaa  1920
tttggattt  tgtttgtga  cttattaat  tctgacaac  ccctaattg  agctatgga  1980
ttccctgtt  cttcttctc  cataccatt  aaatgtgtg  tccttagtt  ctacctata  2040
aaataaaac  gggtgtgca  tttagccag  ccctccccc  ctggtttgt  gagagggag  2100
caagggtgt  ggaggtaga  agagaagag  aattgttta  tagggaagg  aaggaagga  2160
ggtaaaaag  tgttgcaag  tgggcatgg  aagccagcc  gttatccca  tattgtccc  2220
gtagtcagg  ggagcagag  ttcaaggtc  gcctcatct  tagagtgag  tttctgcca  2280
ctggactac  tgagacact  tcttaaaaac  2310



<210> 8223
<211> 507
<212> PRT
<213> Rattus norvegicus
<308> U19614
<400> 8223

Met Ala Gly Glu Arg Trp Arg Ala Glu Gly Leu Gly Glu Gly Trp Ala 
  1               5                  10                  15
Ile Tyr Val Thr Pro Arg Ala Pro Ile Arg Glu Gly Arg Arg Arg Leu 
             20                  25                  30
Ala Thr Gln Asn Gly Asp Gly Ser Asp Ala Pro Ala Tyr Glu Thr His 
         35                  40                  45
Pro Ser Arg His Gly Arg Arg Glu Val Arg Phe Ser Glu Glu Pro Pro 
     50                  55                  60
Glu Val Tyr Gly Asp Phe Glu Pro Arg Ala Ala Lys Glu Arg Ser Pro 
 65                  70                  75                  80
Gly Glu Arg Arg Thr Pro Pro Glu Lys Phe Arg Ser Asp Ser Ala Lys 
                 85                  90                  95
Glu Glu Val Arg Glu Ser Ala Tyr Asn Leu Arg Ser Arg Gln Arg Arg 
             100                105                110
Gln Arg Gly Pro Gln Glu Ala Glu Glu Met Lys Thr Arg Arg Ser Thr 
         115                120                125
Arg Leu Glu Gln His Ser Gln Gln Ala Gln Gln Gln Leu Ser Pro Ala 
     130                135                140
Thr Ser Gly Arg Gly Leu Arg Asp Ala Gln Ser Leu Ser Glu Asp Arg 
 145                150                155                160
Gly Glu Asp Glu Pro Ser Ser Gln Pro Val Thr Ser Gln Thr Val Ser 
                 165                170                175
Lys Lys Thr Val Arg Thr Pro Glu Thr Ser Val Met Ser Glu Asp Pro 
             180                185                190
Ile Ser Asn Leu Cys Arg Pro Pro Leu Arg Ser Pro Arg Pro Asp Ala 
         195                200                205
Ser Ile Val Gln His Ile Asn Pro Phe Glu Glu Asp Glu Ala Ala Val 
     210                215                220
Ala Ala Gly His His Pro Asp Ser Leu Trp Gly Leu Pro His Ser Arg 
 225                230                235                240
Gly Asp Phe Thr Ala His Glu Asn Gln Pro Ser Leu Leu Pro Thr Gly 
                 245                250                255
Cys Gln Lys Asn Pro Gln Glu Trp Val Glu Gln Ala Val Arg Met Arg 
             260                265                270
Thr Arg Met Ala Tyr Asn Asn Ile Gln Lys Ser Asp Phe Gly Asn Gln 
         275                280                285
Ser Pro Ser Thr Ser Arg Gln Gln Ala Ala Val Gln Pro Pro Asp Glu 
     290                295                300
Ser Ser Val Lys Ile Lys Trp Trp Leu Leu Ile Leu Val Ala Ala Leu 
 305                310                315                320
Ala Met Gly Ile Tyr Trp Phe Phe His Thr Pro Val Val Glu Ile Thr 
                 325                330                335
Ala Ala Gln Asp Ala Ala Glu Val Leu Lys Cys Leu Ser Glu Gln Ile 
             340                345                350
Ala Asp Ala Tyr Ser Ser Phe Arg Ser Val Arg Ala Ile Arg Ile Asp 
         355                360                365
Gly Ala Gly Lys Ala Ala Gln Asp Ser Asp Leu Val Lys His Glu Val 
     370                375                380
Asp Gln Glu Leu Thr Asp Gly Phe Arg Asn Gly Gln Asn Ala Ala Val 
 385                390                395                400
Val His Arg Phe Glu Ser Leu Pro Ala Gly Ser Thr Leu Ile Phe Tyr 
                 405                410                415
Lys Tyr Cys Asp His Glu Asn Ala Ala Phe Lys Asp Val Ala Leu Val 
             420                425                430
Leu Thr Val Leu Leu Glu Glu Gln Thr Leu Glu Ala Ser Leu Gly Leu 
         435                440                445
Lys Glu Ile Glu Glu Lys Val Arg Asp Phe Leu Lys Val Lys Phe Thr 
     450                455                460
Ser Ser Asp Thr Ala Asn Ser Tyr Asn His Met Asp Pro Asp Lys Leu 
 465                470                475                480
Asn Gly Leu Trp Ser Arg Ile Ser His Leu Val Leu Pro Val Gln Pro 
                 485                490                495
Glu Asn Ala Leu Lys Ala Gly Ser Cys Leu Ter 
             500                505



<210> 8224
<211> 1653
<212> DNA
<213> Homo sapiens
<308> AK021613
<400> 8224

ctagaagag  tccggtccg  ttctgcgaa  gaggaagtg  gagaaagcg  gtactacct  60
cggtctagg  agcggaggc  gccgcgacc  caggaaacc  aggaaatga  gacgcgaag  120
actacccgc  ttcagcagc  gcactcaga  cagcctccg  tacagccgt  tcctgttat  180
accaggaga  ggctgcggg  ctctcattc  tctgaagag  ttgaagcat  ttcccaaac  240
gatttaagc  aaacgatct  aaagaaaac  gtcaggagc  tacaagagg  tccagtgag  300
gaagatctt  taatcaggt  acgtcgacc  cctctaaga  acccaagat  tgaagccac  360
agtgtccaa  agaaggtca  tttctctga  gaaggagaa  ctgaagaag  tgatcaaga  420
agctctcac  gcagtgtca  tactgttaa  gccagatcc  gggattctg  tgaatctgg  480
gataaaacc  ccagatcat  tagtcaata  atagaatca  tttggcagt  atcacaaag  540
caaaacttc  cagctcatg  taagcaacc  tcagtgcta  gctcaggat  tcaaaaaac  600
ccccaggaa  gggccccac  aactgcaag  ataaggacc  ggatgcaaa  tgacagcat  660
ctgaaatca  agcttggaa  ccagtcacc  tcaacctcc  gccgacaag  gactggaca  720
ccccaaaat  catcttttg  caagaggaa  cggtggtgg  tacttcctc  gatagctgc  780
cttgcctct  ggagttttt  gttctttag  actcctgag  tagaaacca  tgctgttca  840
gagttccag  accagatga  tcaacttaa  aataagtac  aaggtcaag  tgagaagct  900
tggaaaagg  gccaaacat  cctggaaaa  catcttaat  gctcccatc  tcggtctca  960
cctgctatc  tactgctca  tgctgcccg  gatgctgaa  aagcactta  gtgtctgag  1020
gaacaaatt  ctgatgcct  ttcttcttt  cgtagtgtc  gtgccatcc  gattgatgg  1080
acagataaa  ctactcaag  cagtgatac  gtcaaacta  aggtagacc  agaactgag  1140
aatgggttt  agaatggcc  gaatgcagc  gtggtacac  gctttgagt  atttcccgc  1200
ggctctact  tgatcttct  caaatattg  gaccatgaa  acgcagcct  caaagatgt  1260
gccttagtc  tgactgtct  attggagga  gagacactt  gaacaagtc  aggcctaaa  1320
gaagttgaa  aaaaagtaa  agattttct  aaagtcaag  tcaccaatt  taacacacc  1380
aactcctac  atcatatgg  cccagacaa  ctgaatggc  tctggagcc  tatttctca  1440
ttagttctg  ctgtgcaac  tgaaaatgc  ctgaaaagg  gcatctgct  ataagaagt  1500
agagagaag  aaaatcatg  cccaagttc  gagaattgt  cacactttc  aaccagaga  1560
agaattcag  gctcttttt  aaagaacta  tttcttttt  aagaagtta  gtgcttaca  1620
aaacatgga  catataaat  attcattca  cct  1653



<210> 8225
<211> 180
<212> PRT
<213> Homo sapiens
<308> CAB43282
<400> 8225

Arg Ser Gln Pro Ala Ile Leu Leu Leu Thr Ala Ala Arg Asp Ala Glu 
  1               5                  10                  15
Glu Ala Leu Arg Cys Leu Ser Glu Gln Ile Ala Asp Ala Tyr Ser Ser 
             20                  25                  30
Phe Arg Ser Val Arg Ala Ile Arg Ile Asp Gly Thr Asp Lys Ala Thr 
         35                  40                  45
Gln Asp Ser Asp Thr Val Lys Leu Glu Val Asp Gln Glu Leu Ser Asn 
     50                  55                  60
Gly Phe Lys Asn Gly Gln Asn Ala Ala Val Val His Arg Phe Glu Ser 
 65                  70                  75                  80
Phe Pro Ala Gly Ser Thr Leu Ile Phe Tyr Lys Tyr Cys Asp His Glu 
                 85                  90                  95
Asn Ala Ala Phe Lys Asp Val Ala Leu Val Leu Thr Val Leu Leu Glu 
             100                105                110
Glu Glu Thr Leu Gly Thr Ser Leu Gly Leu Lys Glu Val Glu Glu Lys 
         115                120                125
Val Arg Asp Phe Leu Lys Val Lys Phe Thr Asn Ser Asn Thr Pro Asn 
     130                135                140
Ser Tyr Asn His Met Asp Pro Asp Lys Leu Asn Gly Leu Trp Ser Arg 
 145                150                155                160
Ile Ser His Leu Val Leu Pro Val Gln Pro Glu Asn Ala Leu Lys Arg 
                 165                170                175
Gly Ile Cys Leu 
             180



<210> 8226
<211> 3032
<212> DNA
<213> Rattus norvegicus
<308> U19866
<400> 8226

agtgctctg  cgagtagtc  tccctcagc  gcagtctct  ggcctcttc  gcttgagcg  60
cggcgagcc  gccacactc  ctaagctcc  ccggcaccg  gcacttgcc  ctgccactg  120
cgcttcgcg  ccgctgcag  cgccggctc  gaatccttc  ggcttccgc  tcagaggag  180
tcttagcct  tcccgaacc  taaccccgg  gagcagatg  agctggacc  tatgacgac  240
ggcggcctc  acgcctacc  tgccccgcg  ggtgggccg  ccgccaaac  caatgtgat  300
ctgcagatt  gtaagtgcc  agctgagat  ctggagcac  tacggagga  ccaccggca  360
ctgttgacc  aagtgtcca  gcaggtgga  cgagagctg  aagggttgc  caggtcggt  420
ggcaagctg  agaacaact  ggacggcta  gtgcccacg  gcgactcac  gcgctggaa  480
aagtccatc  aggcctgtc  ctgccgctg  caggagacc  tcgccaacc  ggagcgctg  540
gtcaagcgt  agatgcacg  gtggaggga  gtcttctac  gtctggaga  gtgggccga  600
cgcctggag  ccatgggcg  caagtaccc  gtgggcagc  agccggccc  ccacactgt  660
tctgtaggt  tggggggtc  agagcccta  tgccaggaa  ctgatggct  cgactacac  720
gttagcccc  atgccatca  cccgccacc  gccgcagga  agctgcctg  gcaggagtc  780
gttggggct  agcaatacc  gtcttgggt  ccaggtgag  atgggcaac  aagcccagg  840
ctggatacc  agatctttg  ggacccacg  gagttcctg  gccacctgg  agagtacct  900
cggcaggtg  gtggctctg  agaatattg  ctgtcccag  tccagaacc  catgaatgg  960
ccagccaag  agtggtggg  gttcaaaca  ggctcggtg  agaactggg  ggagttcaa  1020
aaggagttt  tgcagtaca  tgagggtac  ctctcccgc  aagccattc  gcgggagct  1080
gacctgcca  agaagcagg  tgagccact  gaccagttc  tctggcgta  gcgggacct  1140
taccagaca  tgtatgtgg  cgctgagga  gaggagatc  ttcagtatg  ggtgggcac  1200
ctgcagccc  agttcaagc  ctttctgcg  cacccactt  ccaagaccc  ggagcagct  1260
atccagagg  gcatggaag  tcaggacgg  ctggagcag  cagctgagc  ttctgtcac  1320
cctctgccc  cagaggatg  gactgaggc  ctcacgcct  ctcttacca  cgagtcagt  1380
gccagtgac  ggacccagc  tgaatagag  ggccagccc  gggtcccca  cctgcctgc  1440
acacccagt  tgtggcttt  gtcaactag  acttgattg  gctggggct  acacccaag  1500
ggatgccct  tccagccag  caccttctc  cccactggc  tgactcaca  ctgccacac  1560
accatgatt  atggacatc  agaagcccc  ctcccatag  gctcccacc  gccacctac  1620
cctcacctg  ctgccctag  cctggccct  tctccagtg  cctcaccct  tacactctc  1680
gaccatcac  gaacacctt  ggcttcctc  ttctgcatc  gtgtccagg  ccctttggg  1740
agtcaagaa  tcaagtgtc  gaaaggcaa  gaaaagtag  caccaaacc  aaggggcat  1800
ccagggcag  tgctaaagc  gaatcagag  tggccgaag  aacctctac  tccggggat  1860
cagcccgct  ctacagaca  agcagatcc  gctggtgcc  tacctgcct  ccagagcaa  1920
tggccagtc  tgggcagca  agctcccct  tcagggtga  ctgaagcag  agacctgac  1980
cgctggcgc  tcctggccc  cagcagtga  tcataccag  gaagaaaag  agacttcgg  2040
tccatgact  agccatgcc  ggcggaggg  cccagaggg  ctgagtcct  agccccagc  2100
gaggcagca  ctggagtct  cagagccag  tgaatgaca  caggtctca  gctgctgag  2160
agtctttcc  gccatgtct  gaaggggta  caccccagc  ccagcaccg  cccctcctc  2220
cttgaagct  cctgcacag  ggttccaag  cactttcaa  gcagagaaa  taggattac  2280
aagaggagg  gccttggca  agggcagca  ccagctcag  ctcagagct  aaggtgaag  2340
caagccagc  tgaaacccc  ggtctgcca  gaatgcccg  tccgctggc  actcaccag  2400
tgcctgcca  aagccactg  agcttgagc  gggtctgtg  cctctcagc  cagagccca  2460
ttcgctgcg  ggcctttgg  ccccgccag  accttgcag  agccttaag  ttcgggccc  2520
agcccagcc  gaccttacc  gctgtgccc  gcctgctgg  caagtccag  cccaggaga  2580
cccatgcct  ggctcctag  ctgttccag  cacttccct  acctgccgg  tgattgccc  2640
gctggaacc  catccacac  ccagcacca  ccacctcgt  ttggtaact  ctcgtgtct  2700
tagtctgag  aggccatgt  gaggttcct  catctgcct  gtccattgg  gttctgaga  2760
cagttccac  gctgttctg  cagatcccc  accctgtgc  cctgccagc  cccacaggt  2820
tatttttgc  cataaacca  gacccatac  aatttggct  gctctgggg  ctagggaga  2880
cctggagat  tcaagagtg  ggctatccc  tattttcac  aagccttca  tatccagcc  2940
ggccatctg  cccacacca  cttacctca  agacagaca  atatatata  atacatata  3000
atgattttg  taataaaac  atgaaattt  aa  3032



<210> 8227
<211> 396
<212> PRT
<213> Rattus norvegicus
<308> AAA68695
<400> 8227

Met Glu Leu Asp His Met Thr Thr Gly Gly Leu His Ala Tyr Pro Ala 
  1               5                  10                  15
Pro Arg Gly Gly Pro Ala Ala Lys Pro Asn Val Ile Leu Gln Ile Gly 
             20                  25                  30
Lys Cys Arg Ala Glu Met Leu Glu His Val Arg Arg Thr His Arg His 
         35                  40                  45
Leu Leu Thr Glu Val Ser Lys Gln Val Glu Arg Glu Leu Lys Gly Leu 
     50                  55                  60
His Arg Ser Val Gly Lys Leu Glu Asn Asn Leu Asp Gly Tyr Val Pro 
 65                  70                  75                  80
Thr Gly Asp Ser Gln Arg Trp Lys Lys Ser Ile Lys Ala Cys Leu Cys 
                 85                  90                  95
Arg Cys Gln Glu Thr Ile Ala Asn Leu Glu Arg Trp Val Lys Arg Glu 
             100                105                110
Met His Val Trp Arg Glu Val Phe Tyr Arg Leu Glu Arg Trp Ala Asp 
         115                120                125
Arg Leu Glu Ser Met Gly Gly Lys Tyr Pro Val Gly Ser Glu Pro Ala 
     130                135                140
Arg His Thr Val Ser Val Gly Val Gly Gly Pro Glu Pro Tyr Cys Gln 
 145                150                155                160
Glu Ala Asp Gly Tyr Asp Tyr Thr Val Ser Pro Tyr Ala Ile Thr Pro 
                 165                170                175
Pro Pro Ala Ala Gly Glu Leu Pro Glu Gln Glu Ser Val Gly Ala Gln 
             180                185                190
Gln Tyr Gln Ser Trp Val Pro Gly Glu Asp Gly Gln Pro Ser Pro Gly 
         195                200                205
Leu Asp Thr Gln Ile Phe Glu Asp Pro Arg Glu Phe Leu Ser His Leu 
     210                215                220
Glu Glu Tyr Leu Arg Gln Val Gly Gly Ser Glu Glu Tyr Trp Leu Ser 
 225                230                235                240
Gln Ile Gln Asn His Met Asn Gly Pro Ala Lys Lys Trp Trp Glu Phe 
                 245                250                255
Lys Gln Gly Ser Val Lys Asn Trp Val Glu Phe Lys Lys Glu Phe Leu 
             260                265                270
Gln Tyr Ser Glu Gly Thr Leu Ser Arg Glu Ala Ile Gln Arg Glu Leu 
         275                280                285
Asp Leu Pro Gln Lys Gln Gly Glu Pro Leu Asp Gln Phe Leu Trp Arg 
     290                295                300
Lys Arg Asp Leu Tyr Gln Thr Leu Tyr Val Asp Ala Glu Glu Glu Glu 
 305                310                315                320
Ile Ile Gln Tyr Val Val Gly Thr Leu Gln Pro Lys Phe Lys Arg Phe 
                 325                330                335
Leu Arg His Pro Leu Pro Lys Thr Leu Glu Gln Leu Ile Gln Arg Gly 
             340                345                350
Met Glu Val Gln Asp Gly Leu Glu Gln Ala Ala Glu Pro Ser Val Thr 
         355                360                365
Pro Leu Pro Thr Glu Asp Glu Thr Glu Ala Leu Thr Pro Ala Leu Thr 
     370                375                380
Ser Glu Ser Val Ala Ser Asp Arg Thr Gln Pro Glu 
 385                390                395



<210> 8228
<211> 2935
<212> DNA
<213> Homo sapiens
<308> D87468
<400> 8228

cggacgcgt  ggccgcagc  gccgagccg  acctgcctc  ccgggcgtg  tccgccggc  60
ccgccgccg  cccgcagcg  cagacaggc  ctccccgca  ctccgcacg  gacccaggc  120
gccggaccc  agcgccgga  caccgtccg  ccgccccga  gagtttgcc  cctgccgga  180
cacctgcgc  cagatggag  tggaccacc  gaccagcgg  gggctccac  cctaccccg  240
gccgcgggg  gggcaggtg  ccaagccca  cgtgatcct  cagatcggg  agtgccggg  300
cgagatgct  gagcacgtg  ggcggacgc  ccggcacct  ctggccgag  tgtccaagc  360
ggtggagcg  gagctgaag  ggctgcacc  gtcggtcgg  aagctggag  gcaacctgg  420
cggctacgt  cccacgagc  actcgcagc  ctggaagaa  tccatcaag  cctgcctgt  480
ccgctgcca  gagaccatc  ccaacctgg  gcgctgggt  aagcgcgag  tgcacgtgt  540
gcgcgaggt  ttctaccgc  tggagcgct  ggccgaccg  ctggagtcc  cgggcggca  600
gtacccggt  ggcagcgag  cagcccgcc  caccgtttc  gtgggcgtg  ggggtcccg  660
gagctactg  cacgaggca  acggctacg  ctacaccgt  agcccctac  ccatcaccc  720
gcccccagc  gctggcgag  tgcccgggc  ggagcccgc  gaggcccag  agtaccagc  780
gtgggtccc  ggcgaggac  ggcagccca  ccccggcgt  gacacgcag  tcttcgagg  840
ccctcgaga  ttcctgagc  acctagagg  gtacttgcg  caggtgggc  gctctgagg  900
gtactggct  tcccagatc  agaatcaca  gaacgggcc  gccaagaag  ggtgggagt  960
caagcaggg  tccgtgaag  actgggtgg  gttcaagaa  gagttcctg  agtacagcg  1020
gggcacgct  tcccgagag  ccatccagc  ggagctgga  ctgccgcag  agcagggcg  1080
gccgctgga  cagttcctg  ggcgcaagc  ggacctgta  cagacgctc  acgtggacg  1140
ggacgagga  gagatcatc  agtacgtgg  gggcaccct  cagcccaag  tcaagcgtt  1200
cctgcgcca  cccctgccc  agaccctgg  gcagctcat  cagaggggc  tggaggtgc  1260
ggatgacct  gagcaggcg  ccgagccgg  cggccccca  ctcccggtg  aggatgagg  1320
ggagaccct  acgcccgcc  ccaacagcg  gtccgtggc  agtgaccgg  cccagcccg  1380
gtagagggc  tcccggagc  cccagcctg  ccactacat  cagcctgtg  ctttgccca  1440
caggacttt  gagctgggg  tgactcctg  aggggaagc  ctggtccag  tgggtgccc  1500
ctcgagctc  gggcggact  gcacacact  gtgtcatcc  gatgtgagc  ccgcaccca  1560
cggcaaaga  ccctccccc  tgcagggct  cacccatca  cctccctcc  tctgtcttt  1620
cggcctgga  cccaccctc  acactctca  gccatcaca  aacacccca  cttcctcat  1680
ctgctacaa  acccaggcc  tctggacat  cagaaaacc  agtgtccgg  tggcagggg  1740
cagcggcca  caagctcat  ggacaccca  agcagaagc  agggcagag  caatgctga  1800
ggagcctcg  cttccggcg  cgccgccct  tcccggcat  cgcagagcc  gctgacgcc  1860
tccctgcct  ccagggcag  tggccagcc  cgggcagcg  ggccccctc  tcccagggg  1920
gagtagaag  cgcacacgc  gcagagcag  cctgatgtc  cggtgcttc  tggcccctc  1980
gctccagtg  ttcacgccc  cctggagaa  aatcagagc  cagctcatg  ctcacccat  2040
gcaggcgga  ggtcccaga  gggctgagt  ctcaaatcc  gctgaggca  cagctggca  2100
catcagagc  aggagagtg  caacaggtc  caaggttcc  acaaagtct  tgctgctgt  2160
ctgggcacc  cccacccct  accttgcag  ctgcctgcg  gggaggcga  gtcccagga  2220
agcccagag  ggggctaca  agaggagtc  gctgcagca  agggcagga  ccccagctt  2280
gccctgagc  ccagcgcga  gaccagggc  tgccactaa  cccgccccg  tggccgcca  2340
ctgcccgtc  ccagagcca  tgcagcagg  gtcgggccc  gcctccctc  cagcaggga  2400
accccgccc  ctgccaggc  atcctctct  ccagaggct  tcatgagcc  caaggctgg  2460
gccacagct  ctacccctg  ccagcagcc  tgagctcag  tgcaggaag  acatcccag  2520
agccatggc  cctggggcg  ttccaggca  tctgccctg  cccaacacc  gaaccctgg  2580
gctggtggg  cactagcgt  tgcagccta  gcaggtgct  gctcagggt  catcgttct  2640
ccttgtcca  tgggggacc  gccctgcag  ccactctga  aagtcttca  cccacaccc  2700
gccagcccc  cagatttta  ttttgcaca  aagccataa  caatcctca  ggctggcac  2760
ggctttggg  aagccctgg  gcctgtgaa  accctggaa  cctcatgag  ctgtggcca  2820
cccctgccc  ttgccccac  cagaccagg  cttaaatgt  ggtccaggc  ctgtgcacc  2880
taccccaga  acagactct  tttgtaaga  tttgttaat  aaacactga  acttc  2935



<210> 8229
<211> 396
<212> PRT
<213> Homo sapiens
<308> NP_056008
<400> 8229

Met Glu Leu Asp His Arg Thr Ser Gly Gly Leu His Ala Tyr Pro Gly 
  1               5                  10                  15
Pro Arg Gly Gly Gln Val Ala Lys Pro Asn Val Ile Leu Gln Ile Gly 
             20                  25                  30
Lys Cys Arg Ala Glu Met Leu Glu His Val Arg Arg Thr His Arg His 
         35                  40                  45
Leu Leu Ala Glu Val Ser Lys Gln Val Glu Arg Glu Leu Lys Gly Leu 
     50                  55                  60
His Arg Ser Val Gly Lys Leu Glu Ser Asn Leu Asp Gly Tyr Val Pro 
 65                  70                  75                  80
Thr Ser Asp Ser Gln Arg Trp Lys Lys Ser Ile Lys Ala Cys Leu Cys 
                 85                  90                  95
Arg Cys Gln Glu Thr Ile Ala Asn Leu Glu Arg Trp Val Lys Arg Glu 
             100                105                110
Met His Val Trp Arg Glu Val Phe Tyr Arg Leu Glu Arg Trp Ala Asp 
         115                120                125
Arg Leu Glu Ser Thr Gly Gly Lys Tyr Pro Val Gly Ser Glu Ser Ala 
     130                135                140
Arg His Thr Val Ser Val Gly Val Gly Gly Pro Glu Ser Tyr Cys His 
 145                150                155                160
Glu Ala Asp Gly Tyr Asp Tyr Thr Val Ser Pro Tyr Ala Ile Thr Pro 
                 165                170                175
Pro Pro Ala Ala Gly Glu Leu Pro Gly Gln Glu Pro Ala Glu Ala Gln 
             180                185                190
Gln Tyr Gln Pro Trp Val Pro Gly Glu Asp Gly Gln Pro Ser Pro Gly 
         195                200                205
Val Asp Thr Gln Ile Phe Glu Asp Pro Arg Glu Phe Leu Ser His Leu 
     210                215                220
Glu Glu Tyr Leu Arg Gln Val Gly Gly Ser Glu Glu Tyr Trp Leu Ser 
 225                230                235                240
Gln Ile Gln Asn His Met Asn Gly Pro Ala Lys Lys Trp Trp Glu Phe 
                 245                250                255
Lys Gln Gly Ser Val Lys Asn Trp Val Glu Phe Lys Lys Glu Phe Leu 
             260                265                270
Gln Tyr Ser Glu Gly Thr Leu Ser Arg Glu Ala Ile Gln Arg Glu Leu 
         275                280                285
Asp Leu Pro Gln Lys Gln Gly Glu Pro Leu Asp Gln Phe Leu Trp Arg 
     290                295                300
Lys Arg Asp Leu Tyr Gln Thr Leu Tyr Val Asp Ala Asp Glu Glu Glu 
 305                310                315                320
Ile Ile Gln Tyr Val Val Gly Thr Leu Gln Pro Lys Leu Lys Arg Phe 
                 325                330                335
Leu Arg His Pro Leu Pro Lys Thr Leu Glu Gln Leu Ile Gln Arg Gly 
             340                345                350
Met Glu Val Gln Asp Asp Leu Glu Gln Ala Ala Glu Pro Ala Gly Pro 
         355                360                365
His Leu Pro Val Glu Asp Glu Ala Glu Thr Leu Thr Pro Ala Pro Asn 
     370                375                380
Ser Glu Ser Val Ala Ser Asp Arg Thr Gln Pro Glu 
 385                390                395



<210> 8230
<211> 2996
<212> DNA
<213> Rattus norvegicus
<308> U19893
<400> 8230

gtggggcgg  ctgaaagca  ctgaagcgg  ggccgagtc  taggctccg  cataggggc  60
gcagctgag  ggtagcgga  cggctggcg  gctacgaaa  gacgaggga  ggtggacta  120
cacgccgcg  accaggcgt  ccagtacgg  ccaagcagc  gcggcaatg  acacgggcg  180
cggcggagg  atgggcgac  acatgcgcc  aggaggaga  tgggaccgg  acctgctgt  240
ggacccggc  tgggagaag  agcagcgca  gaccttcac  gcctggtgc  actcccatc  300
gcggaaggc  ggcactcag  tcgagaaca  cgatgagga  ttccgggat  gcttaaact  360
catgcttct  ctggaggtc  tttcagggg  gcggttgcc  aagccagag  gggggaaga  420
gcgagtgca  aagatcaac  atgtaaaca  agccctgga  ttcatcgcc  gcaagggag  480
caagctggt  tccattggg  cagaagaga  cgtggatgg  aatgcaaag  tgaccctgg  540
aatgatctg  accatcatc  tcaggttcg  catccaaga  atctctgtg  aagagacct  600
tgccaagga  ggactcctc  tctggtgcc  gagaaagac  gccccgtat  aaaacgtca  660
cgtccagaa  ttccatatc  gctggaagg  tggtctggc  ttcaacgcg  tcatccacc  720
gcacagacc  gagctgatt  agtatgaca  actgaggaa  gatgatcca  tcaccaacc  780
aaacaatgc  tttgaagtg  ctgagaaat  ccttgatat  cccaagatg  tggatgctg  840
agacatcgt  aacacaggc  ggcccgacg  gaaggccat  atgacatat  tgtccagct  900
ttaccatgc  ttttcagga  cgcagaagg  gagactggt  ccaaccggc  tcttgaagg  960
gctggttgt  aaccaggaa  atgcgcacc  gatggaaga  tacgagcgg  tggcagtgg  1020
tcttctaga  tggatccgg  gcaccatcc  ctggctgga  gaccgtgtg  ctcagaaga  1080
catccagga  atgcagcag  agctggagg  cttccgaga  tataggcgt  tgcacaagc  1140
ccccaaggt  caggagaag  gtcagctgg  gatcaactt  aacaccctg  agaccaagc  1200
gcgggtgag  aaccggcct  ccttcatgc  ctccgaggg  aggatggtc  cggacatca  1260
caatgggtg  caacatctg  agcaggctg  gaagggcta  gaagaatgg  tcttgaatg  1320
aatcccgag  ctggaacga  tgatcaacc  ggcagagaa  tcccggcag  aggcttcca  1380
ccatgaagg  tggaccgat  ggaaggagg  cattctgca  caccgggac  atgagacag  1440
caccctgtc  gacatcaaa  ctctgatcc  aaaacatga  gcctttgag  gtgacctgg  1500
ggcgcacca  gaccgcgtg  agcagatcg  ggctattgc  caggagctc  acgaactgg  1560
ctactatga  tcccacaac  tcaacacac  gtgccagaa  atctgtgac  agtgggata  1620
cctgggctc  ctgacccac  gtcgcaggg  agccttgga  aaaacagag  aacagctgg  1680
gaccatcga  cagctacac  tggagtatg  taagcgggc  gcgcccttc  acaactgga  1740
ggagagtgc  atggaggac  tgcaggaca  gttcatcgt  cacaccatc  aggagatcg  1800
gggcctgat  tcagcccac  accagttca  gtccaccct  ccagatgcc  acagggagc  1860
tgaggccat  ctggccatc  acaaagagg  ccaaaggat  gctgagagc  atcacatca  1920
gctgtcggg  agcaacccc  acaccagcg  tacacccca  atcatcaac  ccaaatggg  1980
gaaggtgca  cagctggtg  cgaagcggg  ccacgcact  ctggaagag  agagcaagc  2040
gcaatccaa  gagcacctt  gccgacagt  tgccagcca  gccaatatg  tggggccct  2100
gatccagac  aagatggag  agattgggc  catctccat  gagatgaac  ggactctgg  2160
agaccagct  agtcacttg  agcagtacg  gcgcagcat  gtggactac  agcccaacc  2220
ggacttgct  gagcagcag  accagctca  ccaggaggc  ctcatcttc  acaacaagc  2280
caccaacta  acaatggag  acctccgtg  gggctggga  cagctgctc  ccaccattg  2340
ccgcaccat  aacgaggta  agaatcaga  cctcacccg  gatgccaag  gcatcagcc  2400
ggagcaaat  caggagttc  gagcctcct  caaccactt  gacaaggac  atggcgggg  2460
actggggcc  gaggagttc  agggctgcc  catcagcct  ggctacgac  tggagaatg  2520
ccggcaggg  gatgctgag  tcaaccgga  catgagtgt  gtcgacccc  accatagtg  2580
cctcgtgac  ttccaagcc  tcattgact  catgtcaaa  gagaccaca  acacagaca  2640
cgccgatca  gtcatcggc  ccttcaagg  cctggccgg  gacaagaac  tcatcactg  2700
tgaggaact  cggagagag  tgccccctg  ccaggctga  tattgcatc  cccgcatgg  2760
cgcctacca  ggccctgat  ctgctccag  cgcccttga  tacaagtcc  tctctacag  2820
cctctatgg  gagagcgac  tgtgagccc  cagccaccc  gaacagact  ccttggcct  2880
cggagggct  aggagccct  ccccaccct  actcagtat  tatgctaag  gctctttgt  2940
gtctctagg  tcagaggca  ggaggggct  ggcaggcct  ttttctcag  ctggta  2996



<210> 8231
<211> 911
<212> PRT
<213> Rattus norvegicus
<308> Q9QXQ0
<400> 8231

Met Val Asp Tyr His Ala Ala Asn Gln Ala Tyr Gln Tyr Gly Pro Ser 
  1               5                  10                  15
Ser Gly Gly Asn Gly Thr Gly Gly Gly Gly Gly Met Gly Asp Tyr Met 
             20                  25                  30
Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp 
         35                  40                  45
Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu 
     50                  55                  60
Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp 
 65                  70                  75                  80
Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu 
                 85                  90                  95
Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val 
             100                105                110
Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser 
         115                120                125
Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Thr Leu Gly 
     130                135                140
Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val 
 145                150                155                160
Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys 
                 165                170                175
Thr Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp 
             180                185                190
Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu 
         195                200                205
Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Thr Asn Leu 
     210                215                220
Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met 
 225                230                235                240
Leu Asp Ala Glu Asp Ile Val Asn Thr Gly Arg Pro Asp Glu Lys Ala 
                 245                250                255
Ile Met Thr Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln 
             260                265                270
Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn 
         275                280                285
Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Arg Leu Ala Ser Asp 
     290                295                300
Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asp Arg Val 
 305                310                315                320
Pro Gln Lys Thr Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg 
                 325                330                335
Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln 
             340                345                350
Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn 
         355                360                365
Arg Pro Ala Phe Met Pro Ser Glu Gly Arg Met Val Ser Asp Ile Asn 
     370                375                380
Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys Gly Tyr Glu Glu Trp 
 385                390                395                400
Leu Leu Asn Glu Ile Pro Arg Leu Glu Arg Leu Asp His Leu Ala Glu 
                 405                410                415
Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys 
             420                425                430
Glu Ala Met Leu Lys His Arg Asp Tyr Glu Thr Ala Thr Leu Ser Asp 
         435                440                445
Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe Glu Ser Asp Leu Ala 
     450                455                460
Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu 
 465                470                475                480
Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val Asn Thr Arg Cys Gln 
                 485                490                495
Lys Ile Cys Asp Gln Trp Asp Asn Leu Gly Ser Leu Thr His Ser Arg 
             500                505                510
Arg Glu Ala Leu Glu Lys Thr Glu Lys Gln Leu Glu Thr Ile Asp Gln 
         515                520                525
Leu His Leu Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met 
     530                535                540
Glu Ser Ala Met Glu Asp Leu Gln Asp Met Phe Ile Val His Thr Ile 
 545                550                555                560
Glu Glu Ile Glu Gly Leu Ile Ser Ala His Asp Gln Phe Lys Ser Thr 
                 565                570                575
Leu Pro Asp Ala Asp Arg Glu Arg Glu Ala Ile Leu Ala Ile His Lys 
             580                585                590
Glu Ala Gln Arg Ile Ala Glu Ser Asn His Ile Lys Leu Ser Gly Ser 
         595                600                605
Asn Pro Tyr Thr Ser Val Thr Pro Gln Ile Ile Asn Ser Lys Trp Glu 
     610                615                620
Lys Val Gln Gln Leu Val Pro Lys Arg Asp His Ala Leu Leu Glu Glu 
 625                630                635                640
Gln Ser Lys Gln Gln Ser Asn Glu His Leu Arg Arg Gln Phe Ala Ser 
                 645                650                655
Gln Ala Asn Met Val Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile 
             660                665                670
Gly Arg Ile Ser Ile Glu Met Asn Gly Thr Leu Glu Asp Gln Leu Ser 
         675                680                685
His Leu Lys Gln Tyr Glu Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu 
     690                695                700
Asp Leu Leu Glu Gln Gln His Gln Leu Ile Gln Glu Ala Leu Ile Phe 
 705                710                715                720
Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Leu Arg Val Gly Trp 
                 725                730                735
Glu Gln Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn 
             740                745                750
Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Gln 
         755                760                765
Glu Phe Arg Ala Ser Phe Asn His Phe Asp Lys Asp His Gly Gly Ala 
     770                775                780
Leu Gly Pro Glu Glu Phe Lys Gly Cys Leu Ile Ser Leu Gly Tyr Asp 
 785                790                795                800
Val Glu Asn Asp Arg Gln Gly Asp Ala Glu Phe Asn Arg Ile Met Ser 
                 805                810                815
Val Val Asp Pro Asn His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile 
             820                825                830
Asp Phe Met Ser Lys Glu Thr Thr Asp Thr Asp Thr Ala Asp Gln Val 
         835                840                845
Ile Gly Ser Phe Lys Val Leu Ala Gly Asp Lys Asn Phe Ile Thr Val 
     850                855                860
Glu Glu Leu Arg Lys Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile 
 865                870                875                880
Ala Arg Met Ala Pro Tyr Gln Gly Pro Asp Ala Ala Pro Gly Ala Leu 
                 885                890                895
Asp Tyr Lys Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu 
             900                905                910



<210> 8232
<211> 2996
<212> DNA
<213> Rattus norvegicus
<308> U19893
<400> 8232

gtggggcgg  ctgaaagca  ctgaagcgg  ggccgagtc  taggctccg  cataggggc  60
gcagctgag  ggtagcgga  cggctggcg  gctacgaaa  gacgaggga  ggtggacta  120
cacgccgcg  accaggcgt  ccagtacgg  ccaagcagc  gcggcaatg  acacgggcg  180
cggcggagg  atgggcgac  acatgcgcc  aggaggaga  tgggaccgg  acctgctgt  240
ggacccggc  tgggagaag  agcagcgca  gaccttcac  gcctggtgc  actcccatc  300
gcggaaggc  ggcactcag  tcgagaaca  cgatgagga  ttccgggat  gcttaaact  360
catgcttct  ctggaggtc  tttcagggg  gcggttgcc  aagccagag  gggggaaga  420
gcgagtgca  aagatcaac  atgtaaaca  agccctgga  ttcatcgcc  gcaagggag  480
caagctggt  tccattggg  cagaagaga  cgtggatgg  aatgcaaag  tgaccctgg  540
aatgatctg  accatcatc  tcaggttcg  catccaaga  atctctgtg  aagagacct  600
tgccaagga  ggactcctc  tctggtgcc  gagaaagac  gccccgtat  aaaacgtca  660
cgtccagaa  ttccatatc  gctggaagg  tggtctggc  ttcaacgcg  tcatccacc  720
gcacagacc  gagctgatt  agtatgaca  actgaggaa  gatgatcca  tcaccaacc  780
aaacaatgc  tttgaagtg  ctgagaaat  ccttgatat  cccaagatg  tggatgctg  840
agacatcgt  aacacaggc  ggcccgacg  gaaggccat  atgacatat  tgtccagct  900
ttaccatgc  ttttcagga  cgcagaagg  gagactggt  ccaaccggc  tcttgaagg  960
gctggttgt  aaccaggaa  atgcgcacc  gatggaaga  tacgagcgg  tggcagtgg  1020
tcttctaga  tggatccgg  gcaccatcc  ctggctgga  gaccgtgtg  ctcagaaga  1080
catccagga  atgcagcag  agctggagg  cttccgaga  tataggcgt  tgcacaagc  1140
ccccaaggt  caggagaag  gtcagctgg  gatcaactt  aacaccctg  agaccaagc  1200
gcgggtgag  aaccggcct  ccttcatgc  ctccgaggg  aggatggtc  cggacatca  1260
caatgggtg  caacatctg  agcaggctg  gaagggcta  gaagaatgg  tcttgaatg  1320
aatcccgag  ctggaacga  tgatcaacc  ggcagagaa  tcccggcag  aggcttcca  1380
ccatgaagg  tggaccgat  ggaaggagg  cattctgca  caccgggac  atgagacag  1440
caccctgtc  gacatcaaa  ctctgatcc  aaaacatga  gcctttgag  gtgacctgg  1500
ggcgcacca  gaccgcgtg  agcagatcg  ggctattgc  caggagctc  acgaactgg  1560
ctactatga  tcccacaac  tcaacacac  gtgccagaa  atctgtgac  agtgggata  1620
cctgggctc  ctgacccac  gtcgcaggg  agccttgga  aaaacagag  aacagctgg  1680
gaccatcga  cagctacac  tggagtatg  taagcgggc  gcgcccttc  acaactgga  1740
ggagagtgc  atggaggac  tgcaggaca  gttcatcgt  cacaccatc  aggagatcg  1800
gggcctgat  tcagcccac  accagttca  gtccaccct  ccagatgcc  acagggagc  1860
tgaggccat  ctggccatc  acaaagagg  ccaaaggat  gctgagagc  atcacatca  1920
gctgtcggg  agcaacccc  acaccagcg  tacacccca  atcatcaac  ccaaatggg  1980
gaaggtgca  cagctggtg  cgaagcggg  ccacgcact  ctggaagag  agagcaagc  2040
gcaatccaa  gagcacctt  gccgacagt  tgccagcca  gccaatatg  tggggccct  2100
gatccagac  aagatggag  agattgggc  catctccat  gagatgaac  ggactctgg  2160
agaccagct  agtcacttg  agcagtacg  gcgcagcat  gtggactac  agcccaacc  2220
ggacttgct  gagcagcag  accagctca  ccaggaggc  ctcatcttc  acaacaagc  2280
caccaacta  acaatggag  acctccgtg  gggctggga  cagctgctc  ccaccattg  2340
ccgcaccat  aacgaggta  agaatcaga  cctcacccg  gatgccaag  gcatcagcc  2400
ggagcaaat  caggagttc  gagcctcct  caaccactt  gacaaggac  atggcgggg  2460
actggggcc  gaggagttc  agggctgcc  catcagcct  ggctacgac  tggagaatg  2520
ccggcaggg  gatgctgag  tcaaccgga  catgagtgt  gtcgacccc  accatagtg  2580
cctcgtgac  ttccaagcc  tcattgact  catgtcaaa  gagaccaca  acacagaca  2640
cgccgatca  gtcatcggc  ccttcaagg  cctggccgg  gacaagaac  tcatcactg  2700
tgaggaact  cggagagag  tgccccctg  ccaggctga  tattgcatc  cccgcatgg  2760
cgcctacca  ggccctgat  ctgctccag  cgcccttga  tacaagtcc  tctctacag  2820
cctctatgg  gagagcgac  tgtgagccc  cagccaccc  gaacagact  ccttggcct  2880
cggagggct  aggagccct  ccccaccct  actcagtat  tatgctaag  gctctttgt  2940
gtctctagg  tcagaggca  ggaggggct  ggcaggcct  ttttctcag  ctggta  2996



<210> 8233
<211> 911
<212> PRT
<213> Rattus norvegicus
<308> Q9QXQ0
<400> 8233

Met Val Asp Tyr His Ala Ala Asn Gln Ala Tyr Gln Tyr Gly Pro Ser 
  1               5                  10                  15
Ser Gly Gly Asn Gly Thr Gly Gly Gly Gly Gly Met Gly Asp Tyr Met 
             20                  25                  30
Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp 
         35                  40                  45
Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu 
     50                  55                  60
Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp 
 65                  70                  75                  80
Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu 
                 85                  90                  95
Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val 
             100                105                110
Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser 
         115                120                125
Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Thr Leu Gly 
     130                135                140
Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val 
 145                150                155                160
Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys 
                 165                170                175
Thr Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp 
             180                185                190
Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu 
         195                200                205
Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Thr Asn Leu 
     210                215                220
Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met 
 225                230                235                240
Leu Asp Ala Glu Asp Ile Val Asn Thr Gly Arg Pro Asp Glu Lys Ala 
                 245                250                255
Ile Met Thr Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln 
             260                265                270
Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn 
         275                280                285
Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Arg Leu Ala Ser Asp 
     290                295                300
Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asp Arg Val 
 305                310                315                320
Pro Gln Lys Thr Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg 
                 325                330                335
Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln 
             340                345                350
Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn 
         355                360                365
Arg Pro Ala Phe Met Pro Ser Glu Gly Arg Met Val Ser Asp Ile Asn 
     370                375                380
Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys Gly Tyr Glu Glu Trp 
 385                390                395                400
Leu Leu Asn Glu Ile Pro Arg Leu Glu Arg Leu Asp His Leu Ala Glu 
                 405                410                415
Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys 
             420                425                430
Glu Ala Met Leu Lys His Arg Asp Tyr Glu Thr Ala Thr Leu Ser Asp 
         435                440                445
Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe Glu Ser Asp Leu Ala 
     450                455                460
Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu 
 465                470                475                480
Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val Asn Thr Arg Cys Gln 
                 485                490                495
Lys Ile Cys Asp Gln Trp Asp Asn Leu Gly Ser Leu Thr His Ser Arg 
             500                505                510
Arg Glu Ala Leu Glu Lys Thr Glu Lys Gln Leu Glu Thr Ile Asp Gln 
         515                520                525
Leu His Leu Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met 
     530                535                540
Glu Ser Ala Met Glu Asp Leu Gln Asp Met Phe Ile Val His Thr Ile 
 545                550                555                560
Glu Glu Ile Glu Gly Leu Ile Ser Ala His Asp Gln Phe Lys Ser Thr 
                 565                570                575
Leu Pro Asp Ala Asp Arg Glu Arg Glu Ala Ile Leu Ala Ile His Lys 
             580                585                590
Glu Ala Gln Arg Ile Ala Glu Ser Asn His Ile Lys Leu Ser Gly Ser 
         595                600                605
Asn Pro Tyr Thr Ser Val Thr Pro Gln Ile Ile Asn Ser Lys Trp Glu 
     610                615                620
Lys Val Gln Gln Leu Val Pro Lys Arg Asp His Ala Leu Leu Glu Glu 
 625                630                635                640
Gln Ser Lys Gln Gln Ser Asn Glu His Leu Arg Arg Gln Phe Ala Ser 
                 645                650                655
Gln Ala Asn Met Val Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile 
             660                665                670
Gly Arg Ile Ser Ile Glu Met Asn Gly Thr Leu Glu Asp Gln Leu Ser 
         675                680                685
His Leu Lys Gln Tyr Glu Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu 
     690                695                700
Asp Leu Leu Glu Gln Gln His Gln Leu Ile Gln Glu Ala Leu Ile Phe 
 705                710                715                720
Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Leu Arg Val Gly Trp 
                 725                730                735
Glu Gln Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn 
             740                745                750
Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Gln 
         755                760                765
Glu Phe Arg Ala Ser Phe Asn His Phe Asp Lys Asp His Gly Gly Ala 
     770                775                780
Leu Gly Pro Glu Glu Phe Lys Gly Cys Leu Ile Ser Leu Gly Tyr Asp 
 785                790                795                800
Val Glu Asn Asp Arg Gln Gly Asp Ala Glu Phe Asn Arg Ile Met Ser 
                 805                810                815
Val Val Asp Pro Asn His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile 
             820                825                830
Asp Phe Met Ser Lys Glu Thr Thr Asp Thr Asp Thr Ala Asp Gln Val 
         835                840                845
Ile Gly Ser Phe Lys Val Leu Ala Gly Asp Lys Asn Phe Ile Thr Val 
     850                855                860
Glu Glu Leu Arg Lys Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile 
 865                870                875                880
Ala Arg Met Ala Pro Tyr Gln Gly Pro Asp Ala Ala Pro Gly Ala Leu 
                 885                890                895
Asp Tyr Lys Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu 
             900                905                910



<210> 8234
<211> 567
<212> DNA
<213> Rattus norvegicus
<308> U20195
<400> 8234

ccagggggg  ccaatggag  ttttggaat  aaattcaat  tttctaatg  gggtcctgc  60
ccagaagca  tcactgata  aattttcca  atcagcaag  caatcgaag  atatgccat  120
tgccctgac  tgaaggtag  cctcagtgt  ctggggaag  agcagtttg  cttggaaaa  180
aagttcaag  ccttcacag  ggagatcgt  gactcagtc  aggcctatg  cacaatgct  240
agaaacatc  ttgatttca  cgcactgaa  gagctactc  ctggcccaa  cagactgaa  300
atccgcatc  acgccatgc  cggagttgt  ggaccgtac  caaagaaga  cctctgtga  360
gaacttggt  cccccgcaa  ctcagctgt  aactgtgtt  ccctggagg  ttttggagg  420
caccaccct  accccaacc  cacctacgc  gctgaccta  tggaaacca  gaagtcagg  480
gagcatgat  tcggggctg  ctttgatgg  gatggggat  ggaacatga  tctgggcaa  540
cacgggttc  ttgtgaacc  ttctgac  567



<210> 8235
<211> 189
<212> PRT
<213> Rattus norvegicus
<308> AAA82891
<400> 8235

Pro Gly Gly Pro Asn Gly Asp Phe Gly Ile Lys Phe Asn Ile Ser Asn 
  1               5                  10                  15
Gly Gly Pro Ala Pro Glu Ala Ile Thr Asp Lys Ile Phe Gln Ile Ser 
             20                  25                  30
Lys Thr Ile Glu Glu Tyr Ala Ile Cys Pro Asp Leu Lys Val Asp Leu 
         35                  40                  45
Ser Val Leu Gly Lys Gln Gln Phe Asp Leu Glu Asn Lys Phe Lys Pro 
     50                  55                  60
Phe Thr Val Glu Ile Val Asp Ser Val Glu Ala Tyr Ala Thr Met Leu 
 65                  70                  75                  80
Arg Asn Ile Phe Asp Phe Asn Ala Leu Lys Glu Leu Leu Ser Gly Pro 
                 85                  90                  95
Asn Arg Leu Lys Ile Arg Ile Asp Ala Met His Gly Val Val Gly Pro 
             100                105                110
Tyr Ala Lys Lys Ile Leu Cys Glu Glu Leu Gly Ala Pro Ala Asn Ser 
         115                120                125
Ala Val Asn Cys Val Pro Leu Glu Asp Phe Gly Gly His His Pro Asp 
     130                135                140
Pro Asn Leu Thr Tyr Ala Ala Asp Leu Val Glu Thr Met Lys Ser Gly 
 145                150                155                160
Glu His Asp Phe Gly Ala Ala Phe Asp Gly Asp Gly Asp Arg Asn Met 
                 165                170                175
Ile Leu Gly Lys His Gly Phe Phe Val Asn Pro Ser Asp 
             180                185



<210> 8236
<211> 3628
<212> DNA
<213> Rattus norvegicus
<308> U20796
<400> 8236

cgctccaac  gtgatgcca  cggcaaccc  aagaacacg  atgtctcta  cattgacgg  60
gttctcaag  gcgaccgca  agactgtcc  gtgaaaaca  gcaaacctg  tgcccctgg  120
atgaccaag  gtcacagcg  aatgacaaa  tttagtggc  tggttctgc  atgtaaagt  180
tgtggggat  tggcctcag  attccacta  ggagttcat  cttgtgaag  ctgtaaggg  240
ttcttcagg  ggagcattc  gcagaacat  cagtacaag  agtgcctga  gaacgagaa  300
tgctccatc  tgaggatga  caggaaccg  tgccagcag  gccgcttca  gaagtgtct  360
tccgtggga  tgtcgcggg  cgctgttcg  tttgggcgg  ttcccaagc  tgaaaaaca  420
agaatgcta  ttgagatgc  aagtgcaat  aagaccatg  tgagcaccc  gttcggtgg  480
cacctgcag  gtgacacct  agcagagcc  catgagcag  cagtaccac  ggctcagga  540
cagctgcgg  ccaagcccc  gctggagca  gaaaacatc  aaagcaccc  tcctccttc  600
gattttgca  aggaggaag  gattggcat  gtgaccaga  cccacaagg  tacctttct  660
tataatcag  aacatcgag  aaactcatc  gagagcatg  caccccata  aggagaacg  720
attcccagg  atgtggagc  atataattt  aatcatgac  atcgtggcg  tgggcttca  780
agccacttc  cctgtagtg  gagccagca  catctcagt  gacagtaca  agggaggaa  840
atgatgcac  acccaaacg  gcataccgt  tgtatttcg  atggacact  tgtgaactt  900
tccagtgct  accctcaaa  agtctgtga  aggattcca  taggtggat  ttctcagac  960
gagagcagg  atagctacc  gtgcagcac  ggagggagg  tgcatctgg  ttgtcctat  1020
agcaagtct  catatgtgg  tcctcagaa  tctggacat  aaatctggg  agaattttc  1080
atgagtttt  ccccagcag  aaaagaggt  gtagaattt  caaaacgta  tcctggctt  1140
cgagatctg  ctcagcatg  tcaggtcaa  ctgttaaaa  ctgggactt  tgaggtttt  1200
atggtgcga  ttgcttcgt  atttgatgc  aaggagcgg  ctgtcacct  cctgagtgg  1260
aagaagtac  gtgtggatg  cctgcactc  atgggagca  gcgatctgc  cagctctat  1320
tttgagttc  gcgagaagc  gaatggcct  cagctcagc  acgaggaaa  gagcttgtt  1380
acagctgtt  ttctggtgt  tgcagatcg  tctggaatt  aaaatgtca  ctcagtgga  1440
gctctgcag  aaacactca  ccgtgcact  aggacctta  taatgaaaa  ccatccaaa  1500
gaggcctcc  tttttacaa  attacttct  aagttgcca  atcttcgat  tttaaacaa  1560
atgcactct  aggaactct  ggcctttaa  gttcatcct  aaggccttt  aacatgaac  1620
gatgctaat  tacatttta  gctgagatg  ttatttata  gtgtatacc  tattgtgaa  1680
atagaaaag  acttagcgc  aggtcctgg  ctgtctgta  tcagtcacc  gtagctgtt  1740
agatgagaa  tcattgtct  gttagacat  ggcccaccc  ccctgtaga  caaccagct  1800
tgttgcact  agactggag  agttacact  aattataat  acactgaat  ttagacttt  1860
tcatctgcc  aagccaaaa  accatgttg  tctccccgg  gtataaatc  agcgcacat  1920
ggagatata  ggaggactt  aacattacc  ctgtgtgac  ggattcggg  gccccacaa  1980
attgatatg  ggtaaagga  actgagaga  aagaggtgt  ctctggcac  gacaaagaa  2040
atggtcctg  gagtcccct  ggttgtggg  aatgataat  gatagtgtc  ccaatgtcc  2100
gcctcacag  gatactgaa  aaatgtcca  aaagcgtct  tacctcttg  gagataggc  2160
ctatgtaaa  aaggtgaag  ttttattat  attgctcat  ataatattc  tgtcttatc  2220
ctaagcatt  ctgggaaac  ttgagagtc  acaccaatt  attcagggt  ccagctcaa  2280
tggggttcc  tactgataa  cacatattc  aggtttatg  acacgtcag  tagtatgtg  2340
acatagtgt  tatgtgaat  taattatat  taaaatctt  cttcacaat  ttttaaact  2400
tgaagaact  tatcataca  taaacttaa  caagaggtg  caaggaccc  aattaggtg  2460
attttacct  ttgctgctg  tgtataacc  ttgctttat  atgtttaga  ggtagaata  2520
tgaagttaa  tctcatatt  ttgtttaag  aacatttaa  gtaaaagtg  aatgagcag  2580
caaatccag  tcagaaaaa  catggattt  agaatacat  tttgataca  tctgcagtt  2640
aaggtaata  atgtttcag  gtttcagat  tctaccttg  gctattaat  gaggtggtg  2700
tgctgcttc  tacctgctg  aggtggatg  cagatttgg  ttctgtgtg  aggatgttt  2760
gtttgggga  aacctttgt  acctattgg  atgtctgtg  ccaagtcca  ttttctttc  2820
ttcccttaa  taacactac  gggattttg  caatttaga  ttaatataa  ttgaaaaac  2880
tttaataag  gacctacct  caggcttag  gatcgtggt  ggagaggta  ccaaagtta  2940
agattcgtg  acaacaccc  tgttccccc  tgagctgta  ttcattgta  tttgggggc  3000
aaattattt  ctgtgtaat  ctagattat  tgaaattgt  aagacatta  gaacatgct  3060
tactattta  agcatgcct  ttactttta  gacatgtaa  cagaatgcc  tattttgta  3120
ttctaactt  ttgctacag  atttgaact  ctgtggtac  gttaagaga  cttgaaaaa  3180
ataaacccc  gttgtcgaa  aagaaagct  atggtgcgt  tgttatgca  tagggacca  3240
aactgctgt  tacattcag  gggtatggc  ttcgtggga  acacagcta  ggtttgtga  3300
ttctttaca  gatagcatt  tcattttat  tttttttca  ggataaacc  atgcatagt  3360
ttcttctat  ggggataga  agctttgtg  agtaatact  aaaacctca  aggttatgt  3420
gattcttca  ttttgcctt  ttcataagt  tctttataa  atgtatctt  aaagcagtt  3480
gcgtctttg  aaatatgta  ccagagctg  tagtgttgc  tgtgatgct  gagttaggg  3540
cagtatata  atgtacaca  ctagataga  gcatgtaga  ttgtatttt  tctcgtaaa  3600
ttttatttc  ataaattct  cctgaagt  3628



<210> 8237
<211> 578
<212> PRT
<213> Rattus norvegicus
<308> Q63504
<400> 8237

Met Glu Leu Asn Ala Gly Gly Val Ile Ala Tyr Ile Ser Ser Ser Ser 
  1               5                  10                  15
Ser Ala Ser Ser Pro Ala Ser Cys His Ser Glu Gly Ser Glu Asn Ser 
             20                  25                  30
Phe Gln Ser Ser Ser Ser Ser Val Pro Ser Ser Pro Asn Ser Ser Asn 
         35                  40                  45
Cys Asp Ala Asn Gly Asn Pro Lys Asn Thr Asp Val Ser Ser Ile Asp 
     50                  55                  60
Gly Val Leu Lys Ser Asp Arg Thr Asp Cys Pro Val Lys Thr Gly Lys 
 65                  70                  75                  80
Pro Gly Ala Pro Gly Met Thr Lys Ser His Ser Gly Met Thr Lys Phe 
                 85                  90                  95
Ser Gly Met Val Leu Leu Cys Lys Val Cys Gly Asp Val Ala Ser Gly 
             100                105                110
Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg 
         115                120                125
Arg Ser Ile Gln Gln Asn Ile Gln Tyr Lys Lys Cys Leu Lys Asn Glu 
     130                135                140
Asn Cys Ser Ile Met Arg Met Asn Arg Asn Arg Cys Gln Gln Cys Arg 
 145                150                155                160
Phe Lys Lys Cys Leu Ser Val Gly Met Ser Arg Asp Ala Val Arg Phe 
                 165                170                175
Gly Arg Ile Pro Lys Arg Glu Lys Gln Arg Met Leu Ile Glu Met Gln 
             180                185                190
Ser Ala Met Lys Thr Met Met Ser Thr Gln Phe Gly Gly His Leu Gln 
         195                200                205
Ser Asp Thr Leu Ala Glu Pro His Glu Gln Ser Val Pro Pro Ala Gln 
     210                215                220
Glu Gln Leu Arg Pro Lys Pro Gln Leu Glu Gln Glu Asn Ile Lys Ser 
 225                230                235                240
Thr Pro Pro Pro Ser Asp Phe Ala Lys Glu Glu Val Ile Gly Met Val 
                 245                250                255
Thr Arg Ala His Lys Asp Thr Phe Leu Tyr Asn Gln Glu His Arg Glu 
             260                265                270
Asn Ser Ser Glu Ser Met Pro Pro His Arg Gly Glu Arg Ile Pro Arg 
         275                280                285
Asn Val Glu Gln Tyr Asn Leu Asn His Asp His Arg Gly Gly Gly Leu 
     290                295                300
His Ser His Phe Pro Cys Ser Glu Ser Gln Gln His Leu Ser Gly Gln 
 305                310                315                320
Tyr Lys Gly Arg Asn Met Met His Tyr Pro Asn Gly His Thr Val Cys 
                 325                330                335
Ile Ser Asn Gly His Cys Val Asn Phe Ser Ser Ala Tyr Pro Gln Arg 
             340                345                350
Val Cys Asp Arg Ile Pro Val Gly Gly Cys Ser Gln Thr Glu Ser Arg 
         355                360                365
Asn Ser Tyr Leu Cys Ser Thr Gly Gly Arg Met His Leu Val Cys Pro 
     370                375                380
Met Ser Lys Ser Pro Tyr Val Asp Pro Gln Lys Ser Gly His Glu Ile 
 385                390                395                400
Trp Glu Glu Phe Ser Met Ser Phe Thr Pro Ala Val Lys Glu Val Val 
                 405                410                415
Glu Phe Ala Lys Arg Ile Pro Gly Phe Arg Asp Leu Ser Gln His Asp 
             420                425                430
Gln Val Asn Leu Leu Lys Ala Gly Thr Phe Glu Val Leu Met Val Arg 
         435                440                445
Phe Ala Ser Leu Phe Asp Ala Lys Glu Arg Thr Val Thr Phe Leu Ser 
     450                455                460
Gly Lys Lys Tyr Ser Val Asp Asp Leu His Ser Met Gly Ala Gly Asp 
 465                470                475                480
Leu Leu Ser Ser Met Phe Glu Phe Ser Glu Lys Leu Asn Gly Leu Gln 
                 485                490                495
Leu Ser Asp Glu Glu Met Ser Leu Phe Thr Ala Val Val Leu Val Ser 
             500                505                510
Ala Asp Arg Ser Gly Ile Glu Asn Val Asn Ser Val Glu Ala Leu Gln 
         515                520                525
Glu Thr Leu Ile Arg Ala Leu Arg Thr Leu Ile Met Lys Asn His Pro 
     530                535                540
Asn Glu Ala Ser Ile Phe Thr Lys Leu Leu Leu Lys Leu Pro Asp Leu 
 545                550                555                560
Arg Ser Leu Asn Asn Met His Ser Glu Glu Leu Leu Ala Phe Lys Val 
                 565                570                575
His Pro 
             580



<210> 8238
<211> 2017
<212> DNA
<213> Homo sapiens
<308> L31785
<400> 8238

ggaggtgaa  gcaggaggt  tgattgcct  tatcagttc  tccagctca  cctcaagcc  60
tgcctcttg  cacagtgag  gttctgaga  tagtttcca  tcctcctcc  cttctgttc  120
atcttctcc  aatagctct  attctgata  caatggtaa  cccaagaat  gtgatctcg  180
caatattga  ggcatcttg  agaatgatc  aatagattg  tctatgaaa  caagcaaat  240
gagtgcacc  gggatgaca  aaagtcata  tggtgtgac  aaatttagt  gcatggttc  300
actgtgtaa  gtctgtggg  atgtggcgt  aggattcca  tatggagtt  atgcttgcg  360
aggctgtaa  ggtttcttt  ggagaagta  tcaacaaaa  atccagtac  agaagtgcc  420
gaagaatga  aactgttct  taatgagaa  gaataggaa  agatgtcag  aatgtcgct  480
caaaaagtg  ctgtctgtt  gaatgtcaa  agatgctgt  cggtttggt  gtattccta  540
gcgtgaaaa  cagaggatg  taattgaaa  gcaaagtgc  atgaagacc  tgatgaaca  600
ccagttcag  ggtcacttg  aaaatgaca  attagtaga  catcatgaa  agacagcct  660
gccagccca  gaacagctg  gacccaagc  ccaactgga  caagaaaac  tcaaaagct  720
ttctcctcc  tcttctgat  ttgcaaagg  agaagtgat  ggcatggtg  ccagagctc  780
caaggatac  tttatgtat  atcaagagc  gcaagaaaa  tcagctgag  gcatgcagc  840
ccagagagg  gaacggatt  ccaagaaca  ggagcaata  aatttaaat  atgatcatt  900
cggcaatgg  cttagcagc  attttccct  tagtgagag  cagcagcat  tcaatggac  960
gttcaaagg  aggaatata  tgcattacc  aaatggtca  gccatttgt  ttgcaaatg  1020
acattgtat  aacttctcc  atgcttata  tcaaagagt  tgtgataga  ttccgatag  1080
tggattttc  cagaatgag  acaagaata  ttacctgtg  aacactgga  gaagaatgc  1140
tctggtttg  ccaatgagt  agtctccat  tgtggatcc  cataaatca  gacatgaaa  1200
ctgggaaga  ttttcgatg  gcttcactc  agcagtgaa  gaagtggtg  aatttgcaa  1260
gcgtattcc  gggttcaga  atctctctc  gcatgacca  gtcaacctt  taaaggctg  1320
gacttttga  gttttaatg  tacggttcg  atcattatt  gatgcaaag  aacgaactg  1380
caccttttt  agtggaaag  aatatagtg  ggatgattt  cactcaatg  gagcagggg  1440
tctgctaaa  tctatgttt  aatttagtg  gaagctaaa  gccctccaa  ttagtgatg  1500
agagatgag  ttgtttaca  ctgttgtcc  ggtatctgc  gatcgatct  gaaatagaa  1560
aaacgtcaa  tctgtggag  ctttgcagg  aactctcat  cgtgcacta  ggaccttaa  1620
aatgaaaaa  catccaaat  aggcctcta  ttttacaaa  ctgcttcta  agttgccag  1680
tcttcgatc  ttaaacaac  tgcactctg  ggagctctt  gcctttaaa  ttcaccctt  1740
aggcctttg  ttatttaaa  atgaactga  ggtaactgt  cattttgtg  taaaatgca  1800
atttatatg  gtataccat  tgtggagat  gaaaagacc  ttaagcaat  aaagattgt  1860
ggctatctc  gtaatcatg  aatagctgt  cggattgag  actcttcag  catgattag  1920
cgttgactg  atctccctg  tagaccaat  agctgtgtc  cacttaaac  ggagaagtt  1980
cactgaagt  taatcacac  gaatgttag  ccttttc  2017



<210> 8239
<211> 579
<212> PRT
<213> Homo sapiens
<308> Q14995
<400> 8239

Met Glu Val Asn Ala Gly Gly Val Ile Ala Tyr Ile Ser Ser Ser Ser 
  1               5                  10                  15
Ser Ala Ser Ser Pro Ala Ser Cys His Ser Glu Gly Ser Glu Asn Ser 
             20                  25                  30
Phe Gln Ser Ser Ser Ser Ser Val Pro Ser Ser Pro Asn Ser Ser Asn 
         35                  40                  45
Ser Asp Thr Asn Gly Asn Pro Lys Asn Gly Asp Leu Ala Asn Ile Glu 
     50                  55                  60
Gly Ile Leu Lys Asn Asp Arg Ile Asp Cys Ser Met Lys Thr Ser Lys 
 65                  70                  75                  80
Ser Ser Ala Pro Gly Met Thr Lys Ser His Ser Gly Val Thr Lys Phe 
                 85                  90                  95
Ser Gly Met Val Leu Leu Cys Lys Val Cys Gly Asp Val Ala Ser Gly 
             100                105                110
Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg 
         115                120                125
Arg Ser Ile Gln Gln Asn Ile Gln Tyr Lys Lys Cys Leu Lys Asn Glu 
     130                135                140
Asn Cys Ser Ile Met Arg Met Asn Arg Asn Arg Cys Gln Gln Cys Arg 
 145                150                155                160
Phe Lys Lys Cys Leu Ser Val Gly Met Ser Arg Asp Ala Val Arg Phe 
                 165                170                175
Gly Arg Ile Pro Lys Arg Glu Lys Gln Arg Met Leu Ile Glu Met Gln 
             180                185                190
Ser Ala Met Lys Thr Met Met Asn Ser Gln Phe Ser Gly His Leu Gln 
         195                200                205
Asn Asp Thr Leu Val Glu His His Glu Gln Thr Ala Leu Pro Ala Gln 
     210                215                220
Glu Gln Leu Arg Pro Lys Pro Gln Leu Glu Gln Glu Asn Ile Lys Ser 
 225                230                235                240
Ser Ser Pro Pro Ser Ser Asp Phe Ala Lys Glu Glu Val Ile Gly Met 
                 245                250                255
Val Thr Arg Ala His Lys Asp Thr Phe Met Tyr Asn Gln Glu Gln Gln 
             260                265                270
Glu Asn Ser Ala Glu Ser Met Gln Pro Gln Arg Gly Glu Arg Ile Pro 
         275                280                285
Lys Asn Met Glu Gln Tyr Asn Leu Asn His Asp His Cys Gly Asn Gly 
     290                295                300
Leu Ser Ser His Phe Pro Cys Ser Glu Ser Gln Gln His Leu Asn Gly 
 305                310                315                320
Gln Phe Lys Gly Arg Asn Ile Met His Tyr Pro Asn Gly His Ala Ile 
                 325                330                335
Cys Ile Ala Asn Gly His Cys Met Asn Phe Ser Asn Ala Tyr Thr Gln 
             340                345                350
Arg Val Cys Asp Arg Val Pro Ile Asp Gly Phe Ser Gln Asn Glu Asn 
         355                360                365
Lys Asn Ser Tyr Leu Cys Asn Thr Gly Gly Arg Met His Leu Val Cys 
     370                375                380
Pro Met Ser Lys Ser Pro Tyr Val Asp Pro His Lys Ser Gly His Glu 
 385                390                395                400
Ile Trp Glu Glu Phe Ser Met Ser Phe Thr Pro Ala Val Lys Glu Val 
                 405                410                415
Val Glu Phe Ala Lys Arg Ile Pro Gly Phe Arg Asp Leu Ser Gln His 
             420                425                430
Asp Gln Val Asn Leu Leu Lys Ala Gly Thr Phe Glu Val Leu Met Val 
         435                440                445
Arg Phe Ala Ser Leu Phe Asp Ala Lys Glu Arg Thr Val Thr Phe Leu 
     450                455                460
Ser Gly Lys Lys Tyr Ser Val Asp Asp Leu His Ser Met Gly Ala Gly 
 465                470                475                480
Asp Leu Leu Asn Ser Met Phe Glu Phe Ser Glu Lys Leu Asn Ala Leu 
                 485                490                495
Gln Leu Ser Asp Glu Glu Met Ser Leu Phe Thr Ala Val Val Leu Val 
             500                505                510
Ser Ala Asp Arg Ser Gly Ile Glu Asn Val Asn Ser Val Glu Ala Leu 
         515                520                525
Gln Glu Thr Leu Ile Arg Ala Leu Arg Thr Leu Ile Met Lys Asn His 
     530                535                540
Pro Asn Glu Ala Ser Ile Phe Thr Lys Leu Leu Leu Lys Leu Pro Asp 
 545                550                555                560
Leu Arg Ser Leu Asn Asn Met His Ser Glu Glu Leu Leu Ala Phe Lys 
                 565                570                575
Val His Pro 
             580



<210> 8240
<211> 3980
<212> DNA
<213> Rattus norvegicus
<308> U21101
<400> 8240

cgggccggg  tggaggggc  ggcgggcgg  tacgagcat  gtcctggtg  tgcaccaca  60
cctcatcgc  gttgtccaa  tcctcaggc  gggccagca  gtcttcctc  agccggacg  120
accgccgcc  cagccatgc  ccgacagcc  gcaggatgc  ttgctgagc  tgggcgccg  180
tatcgacat  gcgggcctt  gacaggctg  caaggatgc  ctctcggcc  tgctcccca  240
agtggagac  gtctacacc  acctggtag  tggggagtc  aggctggtg  gtgaggacc  300
ccctcatga  ctgccacag  aaggaaaaa  tcgagaggc  gtgatttct  ggaagcggc  360
gagctgcga  gggctggga  cttcagacc  actaggaaa  cccttggcc  ggctggtgg  420
tccactggc  cctgacacg  aagtgctgg  catacccct  ctggacaag  agactggaa  480
tgtggcagc  gtcatcttg  tgcactgtg  ccagctgag  gacagtgag  agcagagcc  540
gcaggtggt  gagaagcat  ctctggtgg  cctgcagag  gtgcaggcc  tgcagcagc  600
caggcctga  gctgttcag  acacctcag  ggatccctc  gaagatcaa  aggatgaga  660
gggatacac  gcccatgac  gaaagatcc  gcaactgtg  ggagaactc  atgacttgg  720
tgccacttc  ctgcagctc  aagtccttc  atatcttca  caggagaca  aggccactc  780
ctgctgcct  ctgctggtg  cagaggaca  cctgcagct  tcctgcaag  tcattggag  840
gaaagtgct  ggagaagag  tcagctttc  attgaccat  ggacgcctg  gccaggtgg  900
ggaggacaa  cagtgtatc  agttgaagg  cctaacctc  gacgatgtg  aacagctac  960
aaacatgtt  ggctgtgag  ttcgggcta  gctatgtgt  cctgtcatc  gtcgagcca  1020
tgaccaggt  gtggccctg  cttgcgcct  caacaagct  ggaggagac  tcttcacag  1080
tgaggatga  cgtgcgatc  aacactgct  ccactacac  ggcacggtg  tcaccagta  1140
cttggcctt  cagaaggag  agaagctca  gtgtgagtg  caggctctt  tccaagtgg  1200
aaagaacct  ttcacccac  tggatgacg  ctctgtcct  ctacaggag  tcatcacag  1260
ggccagaaa  ctcagcaac  cagagatct  ctccgtgtt  ctgctggat  agaatgagc  1320
ggttgccaa  gtgttcgat  gcggtgtag  ggacgatga  agttatgag  tccgcatcc  1380
tgcggacca  ggcatcgcg  gccacgtgg  gaccacggg  cagatcctg  acatcccag  1440
tgcatacgc  catccgctt  tctatcgcg  cgtagacga  agcactggc  tccgcacgc  1500
caacattct  tgcttccct  tcaagaacg  gaaccaaga  gtcatcggt  tggctgagc  1560
agtgaacaa  atcaatggg  catggttca  caaatttga  gaggacctg  ccacagcct  1620
ctccatcta  tgtggcatt  gcatcgctc  ctctctcct  tacaaaaag  tgaatgaag  1680
ccagtaccg  agccacctg  ccaacgaga  gatgatgta  catatgaag  tctctgacg  1740
tgaatacac  aaacttctc  atgatggca  ccaacctgt  gccgccatt  actccaact  1800
tgccaactt  acctatact  ctcggtctc  gcctgagga  gatacttct  tggccatcc  1860
gagcatgct  caagacatg  acttcatca  taactacaa  attgactgc  caactctgg  1920
ccggttctg  ctgatggtg  agaaaggct  ccgggatcc  ccctaccac  actggatgc  1980
cgccttctc  gtctctcac  tttgctact  gctctacaa  aatctggag  tctccaact  2040
cctcgagga  atcgagatc  ttgcgttgt  tatttcctg  atgtgtcac  acctggacc  2100
cagaggcac  aacaactcc  tccaggtgg  ctcgaaatc  gtgctggct  cactctaca  2160
ctcagaggg  tctgtcatg  agaggcacc  ctttgctca  gccattgct  tcctcaaca  2220
ccatggctg  aatatcttt  accacttct  tcggaagga  tatcagcga  tgctggacc  2280
gatgaggga  atcatcttg  ccacggacc  ggcacacca  ctccgcatc  tcaaggacc  2340
gcagaagat  gctgaagtg  gttatgacc  aaacaacaa  caacaccac  ggcttcttc  2400
atgcctcct  atgacctcc  gtgacctct  tgaccagac  aagggctgg  agaccacca  2460
aaagattgc  gagctgatc  acaaagagt  cttctccca  ggagacttg  agaaggcca  2520
gggcaaccg  ccaatggag  tgatggatc  ggagaaggc  tacatccct  aacttcaga  2580
cagctttat  gagcacatc  ccatgccca  ctacaagct  ttacaagac  tgttcccca  2640
ggcagcaga  ctgtatgaa  gcgtggcct  caatcgtga  cactggacc  aggtgtccc  2700
caagttcac  atccgaggc  tccccagta  caactcgct  gatttcctg  atgaggaat  2760
tgaggtccc  gatttggac  tcaccaggg  tcctgtcaa  ggctgctgc  gcctcgagg  2820
ctgagtgat  ccctctagg  accctccct  cccggccct  ctttcacaa  tctctacca  2880
tctgtctga  gcattggga  ccagagcca  gggtcctgg  ttctagacc  ggatgtccc  2940
tgtgacctg  cacatgcca  ccttcctgg  cttcgtctt  ctcatctgc  gaaggaatt  3000
gagattcgc  gtctcacac  gacttggcc  tttgttctt  aagagcaca  tagtgacca  3060
tggcagtgg  cttccttct  cacctctga  tgtaccgtg  ccagttctg  ccaagccac  3120
ccatctttg  gccacagaa  cttctgtga  cccattaga  ccccattac  tcagtatcc  3180
tgttttcct  gaggaatcc  aggtctctg  agacttcga  atcctcatg  aagaaggag  3240
ggccaccga  agagcagag  gtataaatc  gtcaccagc  agaagtcgc  atagggtga  3300
gggaccctg  gggtgcctc  gtgcttctg  caggactgg  accctggag  aagctgaca  3360
ccaggttgc  cagtgctct  caggaggca  tgctccagc  gagaaggca  gaataaggg  3420
cagaaggat  ctcaagctg  gagacagtc  ctacacacc  ctgcccttc  ggtgttgtg  3480
cctgaagtg  gttcctttc  ctagctagc  aagacagga  cattagaca  cctattctc  3540
ctttagatc  aagtctccg  cattctgtg  agtccgtga  tggttgtgg  atgctctgc  3600
accctgagg  acagagagc  taacctcct  tcctctgag  gtatccccc  ggtctgagc  3660
cctctccca  tcctgccat  agagagggg  ctggcctct  tccacaggg  ttctctcct  3720
ttcaaggcc  tatccacac  tgccccccg  agggctcag  agactctcc  agggctggg  3780
ctcttgggt  agtggccac  agcttctcc  tctgttttg  tctgtatgt  ttgtgggtg  3840
gggaggggg  cacctgcct  acctactct  agttgcctt  agagagatg  atttttcta  3900
gactctgtg  acctgttgt  gtatgtagt  ctgtgggct  agtgctttg  acatgagaa  3960
aaatctatt  ctttctacca  3980



<210> 8241
<211> 928
<212> PRT
<213> Rattus norvegicus
<308> Q01062
<400> 8241

Met Val Leu Val Leu His His Ile Leu Ile Ala Val Val Gln Phe Leu 
  1               5                  10                  15
Arg Arg Gly Gln Gln Val Phe Leu Lys Pro Asp Glu Pro Pro Pro Gln 
             20                  25                  30
Pro Cys Ala Asp Ser Leu Gln Asp Ala Leu Leu Ser Leu Gly Ala Val 
         35                  40                  45
Ile Asp Ile Ala Gly Leu Arg Gln Ala Ala Lys Asp Ala Leu Ser Ala 
     50                  55                  60
Val Leu Pro Lys Val Glu Thr Val Tyr Thr Tyr Leu Val Asp Gly Glu 
 65                  70                  75                  80
Ser Arg Leu Val Cys Glu Asp Pro Pro His Glu Leu Pro Gln Glu Gly 
                 85                  90                  95
Lys Ile Arg Glu Ala Val Ile Ser Arg Lys Arg Leu Ser Cys Asp Gly 
             100                105                110
Leu Gly Pro Ser Asp Leu Leu Gly Lys Pro Leu Ala Arg Leu Val Ala 
         115                120                125
Pro Leu Ala Pro Asp Thr Gln Val Leu Val Ile Pro Leu Leu Asp Lys 
     130                135                140
Glu Thr Gly Thr Val Ala Ala Val Ile Leu Val His Cys Gly Gln Leu 
 145                150                155                160
Ser Asp Ser Glu Glu Gln Ser Leu Gln Val Val Glu Lys His Ala Leu 
                 165                170                175
Val Ala Leu Gln Arg Val Gln Ala Leu Gln Gln Arg Arg Pro Glu Ala 
             180                185                190
Val Gln Asn Thr Ser Ala Asp Pro Ser Glu Asp Gln Lys Asp Glu Lys 
         195                200                205
Gly Tyr Thr Ala His Asp Arg Lys Ile Leu Gln Leu Cys Gly Glu Leu 
     210                215                220
Tyr Asp Leu Asp Ala Thr Ser Leu Gln Leu Lys Val Leu Arg Tyr Leu 
 225                230                235                240
Gln Gln Glu Thr Gln Ala Thr His Cys Cys Leu Leu Leu Val Ser Glu 
                 245                250                255
Asp Asn Leu Gln Leu Ser Cys Lys Val Ile Gly Glu Lys Val Leu Gly 
             260                265                270
Glu Glu Val Ser Phe Pro Leu Thr Met Gly Arg Leu Gly Gln Val Val 
         275                280                285
Glu Asp Lys Gln Cys Ile Gln Leu Lys Asp Leu Thr Ser Asp Asp Val 
     290                295                300
Gln Gln Leu Gln Asn Met Leu Gly Cys Glu Leu Arg Ala Met Leu Cys 
 305                310                315                320
Val Pro Val Ile Ser Arg Ala Thr Asp Gln Val Val Ala Leu Ala Cys 
                 325                330                335
Ala Phe Asn Lys Leu Gly Gly Asp Phe Phe Thr Asp Glu Asp Glu Arg 
             340                345                350
Ala Ile Gln His Cys Phe His Tyr Thr Gly Thr Val Leu Thr Ser Thr 
         355                360                365
Leu Ala Phe Gln Lys Glu Gln Lys Leu Lys Cys Glu Cys Gln Ala Leu 
     370                375                380
Leu Gln Val Ala Lys Asn Leu Phe Thr His Leu Asp Asp Val Ser Val 
 385                390                395                400
Leu Leu Gln Glu Ile Ile Thr Glu Ala Arg Asn Leu Ser Asn Ala Glu 
                 405                410                415
Ile Cys Ser Val Phe Leu Leu Asp Gln Asn Glu Leu Val Ala Lys Val 
             420                425                430
Phe Asp Gly Gly Val Val Asp Asp Glu Ser Tyr Glu Ile Arg Ile Pro 
         435                440                445
Ala Asp Gln Gly Ile Ala Gly His Val Ala Thr Thr Gly Gln Ile Leu 
     450                455                460
Asn Ile Pro Asp Ala Tyr Ala His Pro Leu Phe Tyr Arg Gly Val Asp 
 465                470                475                480
Asp Ser Thr Gly Phe Arg Thr Arg Asn Ile Leu Cys Phe Pro Ile Lys 
                 485                490                495
Asn Glu Asn Gln Glu Val Ile Gly Val Ala Glu Leu Val Asn Lys Ile 
             500                505                510
Asn Gly Pro Trp Phe Ser Lys Phe Asp Glu Asp Leu Ala Thr Ala Phe 
         515                520                525
Ser Ile Tyr Cys Gly Ile Ser Ile Ala His Ser Leu Leu Tyr Lys Lys 
     530                535                540
Val Asn Glu Ala Gln Tyr Arg Ser His Leu Ala Asn Glu Met Met Met 
 545                550                555                560
Tyr His Met Lys Val Ser Asp Asp Glu Tyr Thr Lys Leu Leu His Asp 
                 565                570                575
Gly Ile Gln Pro Val Ala Ala Ile Asp Ser Asn Phe Ala Asn Phe Thr 
             580                585                590
Tyr Thr Pro Arg Ser Leu Pro Glu Asp Asp Thr Ser Met Ala Ile Leu 
         595                600                605
Ser Met Leu Gln Asp Met Asn Phe Ile Asn Asn Tyr Lys Ile Asp Cys 
     610                615                620
Pro Thr Leu Ala Arg Phe Cys Leu Met Val Lys Lys Gly Tyr Arg Asp 
 625                630                635                640
Pro Pro Tyr His Asn Trp Met His Ala Phe Ser Val Ser His Phe Cys 
                 645                650                655
Tyr Leu Leu Tyr Lys Asn Leu Glu Leu Ser Asn Tyr Leu Glu Asp Ile 
             660                665                670
Glu Ile Phe Ala Leu Phe Ile Ser Cys Met Cys His Asp Leu Asp His 
         675                680                685
Arg Gly Thr Asn Asn Ser Phe Gln Val Ala Ser Lys Ser Val Leu Ala 
     690                695                700
Ala Leu Tyr Ser Ser Glu Gly Ser Val Met Glu Arg His His Phe Ala 
 705                710                715                720
Gln Ala Ile Ala Ile Leu Asn Thr His Gly Cys Asn Ile Phe Asp His 
                 725                730                735
Phe Ser Arg Lys Asp Tyr Gln Arg Met Leu Asp Leu Met Arg Asp Ile 
             740                745                750
Ile Leu Ala Thr Asp Leu Ala His His Leu Arg Ile Phe Lys Asp Leu 
         755                760                765
Gln Lys Met Ala Glu Val Gly Tyr Asp Arg Asn Asn Lys Gln His His 
     770                775                780
Arg Leu Leu Leu Cys Leu Leu Met Thr Ser Cys Asp Leu Ser Asp Gln 
 785                790                795                800
Thr Lys Gly Trp Lys Thr Thr Arg Lys Ile Ala Glu Leu Ile Tyr Lys 
                 805                810                815
Glu Phe Phe Ser Gln Gly Asp Leu Glu Lys Ala Met Gly Asn Arg Pro 
             820                825                830
Met Glu Met Met Asp Arg Glu Lys Ala Tyr Ile Pro Glu Leu Gln Ile 
         835                840                845
Ser Phe Met Glu His Ile Ala Met Pro Ile Tyr Lys Leu Leu Gln Asp 
     850                855                860
Leu Phe Pro Lys Ala Ala Glu Leu Tyr Glu Arg Val Ala Ser Asn Arg 
 865                870                875                880
Glu His Trp Thr Lys Val Ser His Lys Phe Thr Ile Arg Gly Leu Pro 
                 885                890                895
Ser Asn Asn Ser Leu Asp Phe Leu Asp Glu Glu Tyr Glu Val Pro Asp 
             900                905                910
Leu Asp Val Thr Arg Ala Pro Val Asn Gly Cys Cys Ser Leu Glu Gly 
         915                920                925



<210> 8242
<211> 4240
<212> DNA
<213> Homo sapiens
<308> U67733
<400> 8242

cagcagagc  ggattgggg  gttgagtcc  ggctgagta  ggggcagcc  actgctctt  60
gtccctgtg  ctgctgggg  tgccctgcc  tgaactcca  gcagcgggg  cagggcgag  120
tgccacctt  gtctggctg  ggaggcgga  gatgaggag  gatggggca  gcatgcggc  180
actccatcc  ctgcaggag  cagcagtac  cggcagcgc  accggctga  ccgcggggc  240
agcaggtct  cctcaagcc  gacgagccg  cgccgccgc  gcagccatg  gccgacagc  300
tgcaggacg  cttgctgag  ctgggctct  tcatcgaca  ttcaggcct  caacgtgct  360
tcaaggagg  cctgtcagc  gtgctcccc  gagtggaaa  tgtctacac  tacctactg  420
atggtgagt  ccagctggt  tgtgaggac  ccccacatg  gctgcccca  gaggggaaa  480
tccgggagg  tatcatctc  cagaagcgg  tgggctgca  tgggctggg  ttctcagac  540
tgccaggga  gcccttggc  aggctggtg  ctccactgg  tcctgatac  caagtgctg  600
tcatgccgc  agcggacaa  gaggctggg  ccgtggcag  tgtcatctt  gtgcactgt  660
gccagctga  tgataatga  gaatggagc  tgcaggcgg  ggagaagca  accctggtc  720
ccctgcgga  ggtgcaggt  ctgcagcag  gcgggccca  ggaggctcc  cgagccgtc  780
agaaccccc  ggaggggac  gcggaagac  agaagggcg  ggcggcgta  accgaccgc  840
accgcaaga  cctccaact  tgcggggaa  tctacgacc  ggatgcctc  tccctgcag  900
tcaaagtgc  ccaatacct  cagcaggag  cccgggcat  ccgctgctg  ctcctgctg  960
tgtcggagg  caatctcca  ctttcttgc  aggtcatcg  agacaaagt  ctcggggaa  1020
aggtcagct  tcccttgac  ggatgcctg  gccaggtgg  ggaagacaa  aagtccatc  1080
agctgaagg  cctcacctc  gaggatgta  aacagctgc  gagcatgtt  ggctgtgag  1140
tgcaggcca  gctctgtgt  cctgtcatc  gccgggcca  tgaccaggt  gtggccttg  1200
cctgcgcct  caacaagct  gaaggagac  tgttcaccg  cgaggacga  catgtgatc  1260
agcactgct  ccactacac  agcaccgtg  tcaccagca  cctggcctt  cagaaggaa  1320
agaaactca  gtgtgagtg  caggctctt  tccaagtgg  aaagaacct  ttcacccac  1380
tggatgacg  ctctgtcct  ctccaggag  tcatcacgg  ggccagaaa  ctcagcaac  1440
cagagatct  ctctgtgtt  ctgctggat  agaatgagc  ggtggccaa  gtgttcgac  1500
ggggcgtgg  ggatgatga  agctatgag  tccgcatcc  ggccgatca  ggcatcgcg  1560
gacacgtgg  gaccacggg  cagatcctg  acatccctg  cgcatatgc  catccgctt  1620
tctaccgcg  cgtggacga  agcaccggc  tccgcacgc  caacatcct  tgcttcccc  1680
tcaagaacg  gaaccagga  gtcatcggt  tggccgagc  ggtgaacaa  atcaatggg  1740
catggttca  caagttcga  gaggacctg  cgacggcct  ctccatcta  tgcggcatc  1800
gcatcgccc  ttctctcct  tacaaaaaa  tgaatgagg  tcagtatcg  agccacctg  1860
ccaatgaga  gatgatgta  cacatgaag  tctccgacg  tgagtatac  aaacttctc  1920
atgatggga  ccagcctgt  gctgccatt  actccaatt  tgcaagttt  acctatacc  1980
ctcgttccc  gcccgagga  gacacgtcc  tggccatcc  gagcatgct  caggacatg  2040
atttcatca  caactacaa  attgactgc  cgaccctgg  ccggttctg  ttgatggtg  2100
agaagggct  ccgggatcc  ccctaccac  actggatgc  cgccttttc  gtctcccac  2160
tctgctacc  gctctacaa  aacctggag  tcaccaact  cctcgagga  atcgagatc  2220
ttgccttgt  tatttcctg  atgtgtcat  acctggacc  cagaggcac  aacaactct  2280
tccaggtgg  ctcgaaatc  gtgctggct  cgctctaca  ctctgaggg  tccgtcatg  2340
agaggcacc  ctttgctca  gccatcgcc  tcctcaaca  ccacggctg  aacatcttt  2400
atcatttct  ccggaagga  tatcagcgc  tgctggatc  gatgcggga  atcatcttg  2460
ccacagacc  ggcccacca  ctccgcatc  tcaaggacc  ccagaagat  gctgaggtg  2520
gctacgacc  aaacaacaa  cagcaccac  gacttctcc  ctgcctcct  atgacctcc  2580
gtgacctct  tgaccagac  aagggctgg  agactacga  aaagatcgc  gagctgatc  2640
acaaagaat  cttctccca  ggagacctg  agaaggcca  gggcaacag  ccgatggag  2700
tgatggacc  ggagaaggc  tatatccct  agctgcaaa  cagcttcat  gagcacatt  2760
caatgccca  ctacaagct  ttgcaggac  tgttcccca  agcggcaga  ctgtacgag  2820
gcgtggcct  caaccgtga  cactggacc  aggtgtccc  caagttcac  atccgcggc  2880
tcccaagta  caactcgct  gacttcctg  atgaggagt  cgaggtgcc  gatctggat  2940
gcactaggg  ccccatcaa  ggctgctgc  gccttgatg  tgagtgatc  cctccagga  3000
acttccctg  ccaggccac  tcccacagc  ctccactgg  ctggccaga  gcactggga  3060
cagagccac  ggtcctggg  cctagacca  gacttcctg  gtgaccctg  acaagtact  3120
ccttcctgg  cctcagctt  ctcgtctgt  taatggaag  aagacttcc  acctcacgg  3180
gactttgta  tttgcttct  tgagagcac  ggggtgacc  atgagcagt  ggccctact  3240
tgcacctct  accacacct  ggcaagtct  tcccaagcc  ttctttgtc  gagcagctt  3300
atggtttct  cttgcccca  ttctgcccc  ccagatctt  gctcctttc  ctttgagga  3360
tcccaccct  tgggtctcc  ggatcctca  ggaagggga  ggtgagaca  ctgagtgag  3420
agagtgtgg  atcttggaa  cagtcctta  ttctgtggg  ggactagaa  cagccgcgg  3480
gaaggcccc  tgaggacca  tactatact  atggtggga  tgggacctg  gggatacag  3540
ggccccagg  agaagctgg  cagaggggc  gctcagtgc  ctgcagaga  gggccctgg  3600
gagaagcag  atgggattg  tgggcagga  ggatccccg  actgggaga  aggcccagg  3660
atgaatgag  cagccatgc  tcctcctgc  tgtgtgacg  tgggcgagt  tcttcccct  3720
tctgggcca  acagggagc  ggtaagaca  tccatgctc  aagatccat  ttagatcaa  3780
gtctaaaat  gctctatgg  tctgcggag  cccagcaga  gctatggaa  gtttctgca  3840
ccctaaggc  cagagagcc  accctgagt  tctcagagg  cccctgagt  ttccccttg  3900
cctgagccc  ttacccatt  ctgcagcca  tgagagacc  ggcctcagc  tggcagcgc  3960
ctcttcaag  ccatatcca  ctgtgccct  gggcttggg  gaccccata  gccgggact  4020
ttgggtcag  ccgccactg  cttctctct  tttctccgt  tcattctgt  tgcgttgtg  4080
ggtggggga  ggggtccac  tgccttacc  ttctgagtt  cctttagag  gatgcgttt  4140
tctaggact  tgtgcaact  tcgtatatg  tcccgtggg  tgaccgctt  gtacatgag  4200
ataaatcta  ttctttcta  caaaaaaaa  aaaaaaaaaa  4240



<210> 8243
<211> 941
<212> PRT
<213> Homo sapiens
<308> O00408
<400> 8243

Met Gly Gln Ala Cys Gly His Ser Ile Leu Cys Arg Ser Gln Gln Tyr 
  1               5                  10                  15
Pro Ala Ala Arg Pro Ala Glu Pro Arg Gly Gln Gln Val Phe Leu Lys 
             20                  25                  30
Pro Asp Glu Pro Pro Pro Pro Pro Gln Pro Cys Ala Asp Ser Leu Gln 
         35                  40                  45
Asp Ala Leu Leu Ser Leu Gly Ser Val Ile Asp Ile Ser Gly Leu Gln 
     50                  55                  60
Arg Ala Val Lys Glu Ala Leu Ser Ala Val Leu Pro Arg Val Glu Thr 
 65                  70                  75                  80
Val Tyr Thr Tyr Leu Leu Asp Gly Glu Ser Gln Leu Val Cys Glu Asp 
                 85                  90                  95
Pro Pro His Glu Leu Pro Gln Glu Gly Lys Val Arg Glu Ala Ile Ile 
             100                105                110
Ser Gln Lys Arg Leu Gly Cys Asn Gly Leu Gly Phe Ser Asp Leu Pro 
         115                120                125
Gly Lys Pro Leu Ala Arg Leu Val Ala Pro Leu Ala Pro Asp Thr Gln 
     130                135                140
Val Leu Val Met Pro Leu Ala Asp Lys Glu Ala Gly Ala Val Ala Ala 
 145                150                155                160
Val Ile Leu Val His Cys Gly Gln Leu Ser Asp Asn Glu Glu Trp Ser 
                 165                170                175
Leu Gln Ala Val Glu Lys His Thr Leu Val Ala Leu Arg Arg Val Gln 
             180                185                190
Val Leu Gln Gln Arg Gly Pro Arg Glu Ala Pro Arg Ala Val Gln Asn 
         195                200                205
Pro Pro Glu Gly Thr Ala Glu Asp Gln Lys Gly Gly Ala Ala Tyr Thr 
     210                215                220
Asp Arg Asp Arg Lys Ile Leu Gln Leu Cys Gly Glu Leu Tyr Asp Leu 
 225                230                235                240
Asp Ala Ser Ser Leu Gln Leu Lys Val Leu Gln Tyr Leu Gln Gln Glu 
                 245                250                255
Thr Arg Ala Ser Arg Cys Cys Leu Leu Leu Val Ser Glu Asp Asn Leu 
             260                265                270
Gln Leu Ser Cys Lys Val Ile Gly Asp Lys Val Leu Gly Glu Glu Val 
         275                280                285
Ser Phe Pro Leu Thr Gly Cys Leu Gly Gln Val Val Glu Asp Lys Lys 
     290                295                300
Ser Ile Gln Leu Lys Asp Leu Thr Ser Glu Asp Val Gln Gln Leu Gln 
 305                310                315                320
Ser Met Leu Gly Cys Glu Leu Gln Ala Met Leu Cys Val Pro Val Ile 
                 325                330                335
Ser Arg Ala Thr Asp Gln Val Val Ala Leu Ala Cys Ala Phe Asn Lys 
             340                345                350
Leu Glu Gly Asp Leu Phe Thr Asp Glu Asp Glu His Val Ile Gln His 
         355                360                365
Cys Phe His Tyr Thr Ser Thr Val Leu Thr Ser Thr Leu Ala Phe Gln 
     370                375                380
Lys Glu Gln Lys Leu Lys Cys Glu Cys Gln Ala Leu Leu Gln Val Ala 
 385                390                395                400
Lys Asn Leu Phe Thr His Leu Asp Asp Val Ser Val Leu Leu Gln Glu 
                 405                410                415
Ile Ile Thr Glu Ala Arg Asn Leu Ser Asn Ala Glu Ile Cys Ser Val 
             420                425                430
Phe Leu Leu Asp Gln Asn Glu Leu Val Ala Lys Val Phe Asp Gly Gly 
         435                440                445
Val Val Asp Asp Glu Ser Tyr Glu Ile Arg Ile Pro Ala Asp Gln Gly 
     450                455                460
Ile Ala Gly His Val Ala Thr Thr Gly Gln Ile Leu Asn Ile Pro Asp 
 465                470                475                480
Ala Tyr Ala His Pro Leu Phe Tyr Arg Gly Val Asp Asp Ser Thr Gly 
                 485                490                495
Phe Arg Thr Arg Asn Ile Leu Cys Phe Pro Ile Lys Asn Glu Asn Gln 
             500                505                510
Glu Val Ile Gly Val Ala Glu Leu Val Asn Lys Ile Asn Gly Pro Trp 
         515                520                525
Phe Ser Lys Phe Asp Glu Asp Leu Ala Thr Ala Phe Ser Ile Tyr Cys 
     530                535                540
Gly Ile Ser Ile Ala His Ser Leu Leu Tyr Lys Lys Val Asn Glu Ala 
 545                550                555                560
Gln Tyr Arg Ser His Leu Ala Asn Glu Met Met Met Tyr His Met Lys 
                 565                570                575
Val Ser Asp Asp Glu Tyr Thr Lys Leu Leu His Asp Gly Ile Gln Pro 
             580                585                590
Val Ala Ala Ile Asp Ser Asn Phe Ala Ser Phe Thr Tyr Thr Pro Arg 
         595                600                605
Ser Leu Pro Glu Asp Asp Thr Ser Met Ala Ile Leu Ser Met Leu Gln 
     610                615                620
Asp Met Asn Phe Ile Asn Asn Tyr Lys Ile Asp Cys Pro Thr Leu Ala 
 625                630                635                640
Arg Phe Cys Leu Met Val Lys Lys Gly Tyr Arg Asp Pro Pro Tyr His 
                 645                650                655
Asn Trp Met His Ala Phe Ser Val Ser His Phe Cys Tyr Leu Leu Tyr 
             660                665                670
Lys Asn Leu Glu Leu Thr Asn Tyr Leu Glu Asp Ile Glu Ile Phe Ala 
         675                680                685
Leu Phe Ile Ser Cys Met Cys His Asp Leu Asp His Arg Gly Thr Asn 
     690                695                700
Asn Ser Phe Gln Val Ala Ser Lys Ser Val Leu Ala Ala Leu Tyr Ser 
 705                710                715                720
Ser Glu Gly Ser Val Met Glu Arg His His Phe Ala Gln Ala Ile Ala 
                 725                730                735
Ile Leu Asn Thr His Gly Cys Asn Ile Phe Asp His Phe Ser Arg Lys 
             740                745                750
Asp Tyr Gln Arg Met Leu Asp Leu Met Arg Asp Ile Ile Leu Ala Thr 
         755                760                765
Asp Leu Ala His His Leu Arg Ile Phe Lys Asp Leu Gln Lys Met Ala 
     770                775                780
Glu Val Gly Tyr Asp Arg Asn Asn Lys Gln His His Arg Leu Leu Leu 
 785                790                795                800
Cys Leu Leu Met Thr Ser Cys Asp Leu Ser Asp Gln Thr Lys Gly Trp 
                 805                810                815
Lys Thr Thr Arg Lys Ile Ala Glu Leu Ile Tyr Lys Glu Phe Phe Ser 
             820                825                830
Gln Gly Asp Leu Glu Lys Ala Met Gly Asn Arg Pro Met Glu Met Met 
         835                840                845
Asp Arg Glu Lys Ala Tyr Ile Pro Glu Leu Gln Ile Ser Phe Met Glu 
     850                855                860
His Ile Ala Met Pro Ile Tyr Lys Leu Leu Gln Asp Leu Phe Pro Lys 
 865                870                875                880
Ala Ala Glu Leu Tyr Glu Arg Val Ala Ser Asn Arg Glu His Trp Thr 
                 885                890                895
Lys Val Ser His Lys Phe Thr Ile Arg Gly Leu Pro Ser Asn Asn Ser 
             900                905                910
Leu Asp Phe Leu Asp Glu Glu Tyr Glu Val Pro Asp Leu Asp Gly Thr 
         915                920                925
Arg Ala Pro Ile Asn Gly Cys Cys Ser Leu Asp Ala Glu 
     930                935                940



<210> 8244
<211> 428
<212> DNA
<213> Rattus norvegicus
<308> U21719
<400> 8244

caccctaac  taaaccttt  gaattttga  ttaatgggt  ccctataga  aaaatgacc  60
gcggaaaac  aaacagtga  gggaaagaa  gaaagaatt  caattgaca  aatttaaat  120
aaatatggc  tttcaaata  aggaagaga  gtttctttt  ggcacacaa  ctaaacaat  180
tttatgtat  attcagctc  tatttggct  aaatgggct  agtgggaaa  gttatcatt  240
ttactattt  ctacagaga  aatattttc  agtttatca  gtaactctg  actttggaa  300
tacctgttt  tatgttcca  ctgtctata  agttgtttc  ctgaaattg  acataaaat  360
tttttacat  aaaatgaat  actgtataa  gtactgcat  atgcataat  aagatacta  420
tgctttat  428



<210> 8245
<211> 805
<212> PRT
<213> Rattus norvegicus
<308> NP_062426
<400> 8245

Met Glu Glu Ala Val Ser Ser Lys Ala Lys Lys Thr Asn Lys Lys Gly 
  1               5                  10                  15
Pro Ser Glu Asp Asp Val Asp Pro Pro Lys Ser Arg Lys Ala Lys Lys 
             20                  25                  30
Gln Glu Glu Glu Pro Gln Asp Asp Thr Ala Ser Thr Ser Lys Thr Ser 
         35                  40                  45
Lys Lys Lys Lys Glu Pro Leu Glu Lys Gln Ala Asp Ser Glu Thr Lys 
     50                  55                  60
Glu Ile Ile Thr Glu Glu Pro Ser Glu Glu Glu Ala Asp Met Pro Lys 
 65                  70                  75                  80
Pro Lys Lys Met Lys Lys Gly Lys Glu Ala Asn Gly Asp Ala Gly Glu 
                 85                  90                  95
Lys Ser Pro Lys Leu Lys Asn Gly Leu Ser Gln Pro Ser Glu Glu Glu 
             100                105                110
Ala Asp Ile Pro Lys Pro Lys Lys Met Lys Lys Gly Lys Glu Ala Asn 
         115                120                125
Gly Asp Ala Gly Glu Lys Ser Pro Lys Leu Lys Asn Gly Leu Ser Gln 
     130                135                140
Pro Ser Glu Glu Glu Val Asp Ile Pro Lys Pro Lys Lys Met Lys Lys 
 145                150                155                160
Gly Lys Glu Ala Ser Gly Asp Ala Gly Glu Lys Ser Pro Arg Leu Lys 
                 165                170                175
Asp Gly Leu Ser Gln Pro Ser Glu Pro Lys Ser Asn Ser Ser Asp Ala 
             180                185                190
Pro Gly Glu Glu Ser Ser Ser Glu Thr Glu Lys Glu Ile Pro Val Glu 
         195                200                205
Gln Lys Glu Gly Ala Phe Ser Asn Phe Pro Ile Ser Glu Glu Thr Val 
     210                215                220
Lys Leu Leu Lys Ala Arg Gly Val Asn Phe Leu Phe Pro Ile Gln Ala 
 225                230                235                240
Lys Thr Phe His His Val Tyr Ser Gly Lys Asp Leu Ile Ala Gln Ala 
                 245                250                255
Arg Thr Gly Thr Gly Lys Thr Phe Ser Phe Ala Ile Pro Leu Ile Glu 
             260                265                270
Lys Leu Gln Gly Gly Leu Gln Glu Arg Lys Arg Gly Arg Ala Pro Gln 
         275                280                285
Val Leu Val Leu Ala Pro Thr Arg Glu Leu Ala Asn Gln Val Ser Lys 
     290                295                300
Asp Phe Ser Asp Ile Thr Lys Lys Leu Ser Val Ala Cys Phe Tyr Gly 
 305                310                315                320
Gly Thr Pro Tyr Gly Gly Gln Ile Glu Arg Met Arg Ser Gly Ile Asp 
                 325                330                335
Ile Leu Val Gly Thr Pro Gly Arg Ile Lys Asp His Leu Gln Asn Gly 
             340                345                350
Lys Leu Asp Leu Thr Lys Leu Lys His Val Val Leu Asp Glu Val Asp 
         355                360                365
Gln Met Leu Asp Met Gly Phe Ala Asp Gln Val Glu Glu Ile Leu Cys 
     370                375                380
Val Ala Tyr Lys Lys Asp Ser Glu Asp Asn Pro Gln Thr Leu Leu Phe 
 385                390                395                400
Ser Ala Thr Cys Pro His Trp Val Phe Asn Val Ala Lys Lys Tyr Met 
                 405                410                415
Lys Ser Thr Tyr Glu Gln Val Asp Leu Ile Gly Lys Lys Thr Gln Lys 
             420                425                430
Ala Ala Ile Thr Val Glu His Leu Ala Ile Lys Cys His Trp Thr Glu 
         435                440                445
Arg Ala Ala Val Ile Gly Asp Val Ile Arg Val Tyr Ser Gly His Gln 
     450                455                460
Gly Arg Thr Ile Ile Phe Cys Glu Thr Lys Lys Asp Ala Gln Glu Leu 
 465                470                475                480
Ser Gln Asn Thr Cys Ile Lys Gln Asp Ala Gln Ser Leu His Gly Asp 
                 485                490                495
Ile Pro Gln Lys Gln Arg Glu Ile Thr Leu Lys Gly Phe Arg Asn Gly 
             500                505                510
Asn Phe Gly Val Leu Val Ala Thr Asn Val Ala Ala Arg Gly Leu Asp 
         515                520                525
Ile Pro Glu Val Asp Leu Val Val Gln Ser Cys Pro Pro Lys Asp Val 
     530                535                540
Glu Ser Tyr Ile His Arg Ser Gly Arg Thr Gly Arg Ala Gly Arg Thr 
 545                550                555                560
Gly Val Cys Ile Cys Phe Tyr Gln Asn Lys Glu Glu Tyr Gln Leu Ala 
                 565                570                575
Gln Val Glu Gln Lys Ala Gly Ile Lys Phe Lys Arg Ile Gly Val Pro 
             580                585                590
Ser Ala Thr Glu Ile Ile Lys Ala Ser Ser Lys Asp Ala Ile Arg Leu 
         595                600                605
Leu Asp Ser Val Pro Pro Thr Ala Ile Ser His Phe Lys Gln Ser Ala 
     610                615                620
Glu Lys Leu Ile Glu Glu Lys Gly Ala Val Glu Ala Leu Ala Ala Ala 
 625                630                635                640
Leu Ala His Ile Ser Gly Ala Thr Ser Val Asp Gln Arg Ser Leu Ile 
                 645                650                655
Asn Ser Gln Ala Gly Phe Val Thr Met Ile Leu Arg Cys Ser Ile Glu 
             660                665                670
Met Pro Asn Ile Ser Tyr Ala Trp Lys Glu Leu Lys Glu Gln Leu Gly 
         675                680                685
Glu Ser Ile Asp Ala Lys Val Lys Gly Met Val Phe Leu Lys Gly Lys 
     690                695                700
Leu Gly Val Cys Phe Asp Val Arg Thr Glu Ala Val Thr Glu Ile Gln 
 705                710                715                720
Glu Lys Trp His Asp Ser Arg Arg Trp Gln Leu Thr Val Ala Thr Glu 
                 725                730                735
Gln Pro Glu Leu Glu Gly Pro Pro Asp Gly Tyr Arg Gly Arg Met Gly 
             740                745                750
Gln Arg Asp Gly Ser Arg Gly Ala Phe Arg Gly Gln Arg Gly Gly Ser 
         755                760                765
Arg Asn Phe Arg Gly Gln Gly Gln Arg Gly Gly Ser Arg Asn Phe Arg 
     770                775                780
Gly Gln Arg Pro Gly Gly Gly Asn Arg Gly Gln Lys Arg Ser Phe Ser 
 785                790                795                800
Lys Ala Phe Gly Gln 
                 805



<210> 8246
<211> 3319
<212> DNA
<213> Homo sapiens
<308> NM_004728
<400> 8246

ctacctctt  ctctccacg  ggttgagaa  accggtcgg  ctgggcaac  tgcgctgaa  60
atgccggga  aactccgta  tgacgctgg  ttggaatca  acaccgcaa  gaaaaaagg  120
gagacactg  gaaagcaaa  cgaggagaa  gagaaaaaa  gagaagcca  aatctgata  180
gactgaaga  atagcagaa  aggaagaaa  tgttttccc  aaagctaaa  aagttaaaa  240
gaaagcaga  ccttctgaa  ttgacatga  ttctcctaa  tccaaaaag  caaaaaaga  300
agaggagcc  tctcaaaat  acatttctc  taaaaccaa  agtttgaga  agaaaaagg  360
gcccattga  aagaaagtg  tttcttcta  aaccaaaaa  gtgacaaaa  atgaggagc  420
ttctgagga  gaaatagat  ctcctaagc  caagaagat  aagaaagaa  aggaaatga  480
tggagaaac  agagagaaa  gccccaaac  gaagaatgg  tttcctcat  ctgaaccgg  540
ctgtaaccc  agtgaagct  ccagtgaag  aagtaacag  gagatagag  aggaaatac  600
tgtggaaca  aaagaaggc  ctttctcta  ttttcccat  tctgaagaa  ctattaaac  660
tctcaaagg  cgaggagtg  ccttcctat  tcctataca  gcaaagaca  tccatcatg  720
ttacagcgg  aaggactta  ttgcacagg  acggacagg  actgggaag  cattctcct  780
tgccatccc  ttgattgag  aacttcatg  ggaactgca  gacaggaag  gaggccgtg  840
ccctcaggt  ctggttctt  cacctacaa  agagttggc  aatcaagta  gcaaagact  900
cagtgacat  acaaaaaag  tgtcagtgg  ttgttttta  ggtggaact  cctatggag  960
tcaatttga  cgcatgagg  atgggattg  tatcctggt  ggaacacca  gtcgtatca  1020
agaccacat  cagaatggc  aactagatc  caccaaact  aagcatgtt  tcctggatg  1080
agtggacca  atgttggat  tgggatttg  tgatcaagt  gaagagatt  taagtgtgg  1140
atacaagaa  gattctgaa  acaatcccc  aacattgct  ttttctgca  cttgccctc  1200
ttgggtatt  aatgttgcc  agaaataca  gaaatctac  tatgaacag  tggacctga  1260
tggtaaaaa  actcagaaa  cggcaataa  tgtggagca  ctggctatt  agtgccact  1320
gactcagag  gcagcagtt  ttggggatg  catccgagt  tatagtggt  atcaaggac  1380
cactatcat  ttttgtgaa  ccaagaaag  agcccagga  ctgtcccag  attcagcta  1440
aaagcagga  gctcagtcc  tgcatggag  cattccaca  aagcaaagg  aaatcaccc  1500
gaaaggttt  agaaatggt  gttttggag  tttggtggc  accaatgtt  ctgcacgtg  1560
gttagacat  cctgaggtt  atttggtta  acaaagctc  ccaccaaag  atgtagagt  1620
ctacattca  cgatccggg  ggacaggca  agctggaag  acgggggtg  gcatctgct  1680
ttatcagca  aaggaagaa  atcagttag  acaagtgga  caaaaagcg  gaattaagt  1740
caaacgaat  ggtgttcct  ctgcaacag  aataataaa  gcttccagc  aagatgcca  1800
caggctttt  gattccgtg  ctcccactg  cattagtca  ttcaaacaa  cagctgaga  1860
gctgataga  gagaaggga  ctgtggaag  tctggcagc  gcactggcc  atatttcag  1920
tgccacgtc  gtagaccag  gctccttga  caactcaaa  gtgggtttt  tgaccatga  1980
cttgcagtg  tcaattgaa  tgccaaata  tagttatgc  tggaaagaa  ttaaagagc  2040
gctgggcga  gagattgat  ccaaagtga  gggaatggt  tttctcaaa  gaaagctgg  2100
tgtttgctt  gatgtacct  ccgcatcag  aacagaaat  caggagaaa  ggcatgatt  2160
acgacgctg  cagctctct  tggccacag  gcaaccaga  ctggaagga  cacgggaag  2220
atatggagg  ttcagggga  agcgggaag  cagtcgagg  ttcagggga  agcgggacg  2280
aaacagaag  ttcagagga  agcgggaag  cagtagagg  ccgagagga  agcgatcag  2340
aggtggcaa  aaaagtaac  gatcccaaa  caaaggcca  aagcggagt  tcagtaaag  2400
atttggtca  taattagaa  tagaagatt  atatagcaa  aagagaatg  tgtttggca  2460
tatagaact  aacattatt  ttcatgcaa  gttaaaagc  cattgtgcc  ccttttgac  2520
acttgccaa  tccctgtct  tttcagaca  agacaagct  catttaaat  atttcatct  2580
atcattatc  tttataact  tattgttac  tcatcagtt  ttccttttg  aaggtgtat  2640
aattcatta  atttttatt  taatgtatt  tctgtagat  agaagataa  atcaagcat  2700
tatctgcct  tactttgtg  gttcacctg  ctttatact  aaaagtgtc  cttaatagt  2760
tccttccct  aaataaata  ctaagggag  gtaacagtc  ctggaggac  actttgagc  2820
tttggaagt  aaggtttcc  cagccacct  ccgaacagt  tctcatgtg  tcctattat  2880
tgtctactg  gacttaata  tgagcaatg  tttgaaaca  gatttcaaa  taatctggg  2940
tgtaataca  tttatacca  tgtatgctc  agacttgga  gatgtagta  gtttgatgt  3000
gattaccta  acttatgtt  gttttgata  atttttagc  tctcattat  aggtgattc  3060
tgctttagt  aattcttca  agatagtat  tataaaagt  cattttaat  gaaagccag  3120
gttttaagg  atttcacat  tataaggtg  ctccatagc  ttatttgta  gtaggctgg  3180
taaatggtg  ttaaatggt  atgtactcc  cttcttcct  ttggaagat  aacattatt  3240
accaagaag  acttaaggg  gtaaggggc  cagattagc  ttgctcaag  gtatgtaaa  3300
aaaaaaaaa  aaaaaaaaa  3319



<210> 8247
<211> 715
<212> PRT
<213> Homo sapiens
<308> Q9NR30
<400> 8247

Met Asn Ser Pro Lys Ser Lys Lys Ala Lys Lys Lys Glu Glu Pro Ser 
  1               5                  10                  15
Gln Asn Asp Ile Ser Pro Lys Thr Lys Ser Leu Arg Lys Lys Lys Glu 
             20                  25                  30
Pro Ile Glu Lys Lys Val Val Ser Ser Lys Thr Lys Lys Val Thr Lys 
         35                  40                  45
Asn Glu Glu Pro Ser Glu Glu Glu Ile Asp Ala Pro Lys Pro Lys Lys 
     50                  55                  60
Met Lys Lys Glu Lys Glu Met Asn Gly Glu Thr Arg Glu Lys Ser Pro 
 65                  70                  75                  80
Lys Leu Lys Asn Gly Phe Pro His Pro Glu Pro Asp Cys Asn Pro Ser 
                 85                  90                  95
Glu Ala Ala Ser Glu Glu Ser Asn Ser Glu Ile Glu Gln Glu Ile Pro 
             100                105                110
Val Glu Gln Lys Glu Gly Ala Phe Ser Asn Phe Pro Ile Ser Glu Glu 
         115                120                125
Thr Ile Lys Leu Leu Lys Gly Arg Gly Val Thr Phe Leu Phe Pro Ile 
     130                135                140
Gln Ala Lys Thr Phe His His Val Tyr Ser Gly Lys Asp Leu Ile Ala 
 145                150                155                160
Gln Ala Arg Thr Gly Thr Gly Lys Thr Phe Ser Phe Ala Ile Pro Leu 
                 165                170                175
Ile Glu Lys Leu His Gly Glu Leu Gln Asp Arg Lys Arg Gly Arg Ala 
             180                185                190
Pro Gln Val Leu Val Leu Ala Pro Thr Arg Glu Leu Ala Asn Gln Val 
         195                200                205
Ser Lys Asp Phe Ser Asp Ile Thr Lys Lys Leu Ser Val Ala Cys Phe 
     210                215                220
Tyr Gly Gly Thr Pro Tyr Gly Gly Gln Phe Glu Arg Met Arg Asn Gly 
 225                230                235                240
Ile Asp Ile Leu Val Gly Thr Pro Gly Arg Ile Lys Asp His Ile Gln 
                 245                250                255
Asn Gly Lys Leu Asp Leu Thr Lys Leu Lys His Val Val Leu Asp Glu 
             260                265                270
Val Asp Gln Met Leu Asp Met Gly Phe Ala Asp Gln Val Glu Glu Ile 
         275                280                285
Leu Ser Val Ala Tyr Lys Lys Asp Ser Glu Asp Asn Pro Gln Thr Leu 
     290                295                300
Leu Phe Ser Ala Thr Cys Pro His Trp Val Phe Asn Val Ala Lys Lys 
 305                310                315                320
Tyr Met Lys Ser Thr Tyr Glu Gln Val Asp Leu Ile Gly Lys Lys Thr 
                 325                330                335
Gln Lys Thr Ala Ile Thr Val Glu His Leu Ala Ile Lys Cys His Trp 
             340                345                350
Thr Gln Arg Ala Ala Val Ile Gly Asp Val Ile Arg Val Tyr Ser Gly 
         355                360                365
His Gln Gly Arg Thr Ile Ile Phe Cys Glu Thr Lys Lys Glu Ala Gln 
     370                375                380
Glu Leu Ser Gln Asn Ser Ala Ile Lys Gln Asp Ala Gln Ser Leu His 
 385                390                395                400
Gly Asp Ile Pro Gln Lys Gln Arg Glu Ile Thr Leu Lys Gly Phe Arg 
                 405                410                415
Asn Gly Ser Phe Gly Val Leu Val Ala Thr Asn Val Ala Ala Arg Gly 
             420                425                430
Leu Asp Ile Pro Glu Val Asp Leu Val Ile Gln Ser Ser Pro Pro Lys 
         435                440                445
Asp Val Glu Ser Tyr Ile His Arg Ser Gly Arg Thr Gly Arg Ala Gly 
     450                455                460
Arg Thr Gly Val Cys Ile Cys Phe Tyr Gln His Lys Glu Glu Tyr Gln 
 465                470                475                480
Leu Val Gln Val Glu Gln Lys Ala Gly Ile Lys Phe Lys Arg Ile Gly 
                 485                490                495
Val Pro Ser Ala Thr Glu Ile Ile Lys Ala Ser Ser Lys Asp Ala Ile 
             500                505                510
Arg Leu Leu Asp Ser Val Pro Pro Thr Ala Ile Ser His Phe Lys Gln 
         515                520                525
Ser Ala Glu Lys Leu Ile Glu Glu Lys Gly Ala Val Glu Ala Leu Ala 
     530                535                540
Ala Ala Leu Ala His Ile Ser Gly Ala Thr Ser Val Asp Gln Arg Ser 
 545                550                555                560
Leu Ile Asn Ser Asn Val Gly Phe Val Thr Met Ile Leu Gln Cys Ser 
                 565                570                575
Ile Glu Met Pro Asn Ile Ser Tyr Ala Trp Lys Glu Leu Lys Glu Gln 
             580                585                590
Leu Gly Glu Glu Ile Asp Ser Lys Val Lys Gly Met Val Phe Leu Lys 
         595                600                605
Gly Lys Leu Gly Val Cys Phe Asp Val Pro Thr Ala Ser Val Thr Glu 
     610                615                620
Ile Gln Glu Lys Trp His Asp Ser Arg Arg Trp Gln Leu Ser Val Ala 
 625                630                635                640
Thr Glu Gln Pro Glu Leu Glu Gly Pro Arg Glu Gly Tyr Gly Gly Phe 
                 645                650                655
Arg Gly Gln Arg Glu Gly Ser Arg Gly Phe Arg Gly Gln Arg Asp Gly 
             660                665                670
Asn Arg Arg Phe Arg Gly Gln Arg Glu Gly Ser Arg Gly Pro Arg Gly 
         675                680                685
Gln Arg Ser Gly Gly Gly Asn Lys Ser Asn Arg Ser Gln Asn Lys Gly 
     690                695                700
Gln Lys Arg Ser Phe Ser Lys Ala Phe Gly Gln 
 705                710                715



<210> 8248
<211> 463
<212> DNA
<213> Rattus norvegicus
<308> U21721
<400> 8248

cccacctcc  gctgccggc  acaccggtc  ttgcagtct  ggaccccgt  cgatcttta  60
cccggtgca  gatgccccc  aaaaaggga  gagatggac  taaaccgcc  ccgatcatt  120
gaaggtttg  aacctcact  aaaattggt  ctgttggat  gccaaatgt  gggaagtct  180
ccttcttca  tgtgttaac  aatagtcag  cctcagcag  aaacttccc  ttctgcact  240
ttgacccta  cgagagcag  gtgcctgtg  cagacgaga  gtttgactt  cttttgcca  300
tgtcacaag  cagcaagca  gattcctgc  tttccttaa  gttagtggg  ttattgctg  360
gccttgtga  aggagctca  aaatgggca  gggtttggg  gaattgcct  ccttcttca  420
atttaaggg  cgtgatggg  attttcacc  taacgcgtt  ttt  463



<210> 8249
<211> 1754
<212> DNA
<213> Homo sapiens
<308> XM_040050
<400> 8249

gttccaccg  tgtcgccgc  gtagtgcgg  atgccgctc  gcggagggg  cgggcctgc  60
ttctctcct  cttcctccc  gcctctggc  gccggcagg  cctttctct  gctgctact  120
ggaccccgt  tcatagccc  ggctgagca  gatgccccc  caaaaggga  gtgatggaa  180
taaaccacc  ccaatcatt  gaagatttg  aacctcact  aaaattggt  ttgttggat  240
gccaaatgt  gggaaatct  ctttcttca  tgtattaac  aatagtcag  cttcagcag  300
aaacttccc  ttctgcact  ttgatccta  tgagagcag  gtacctgtg  cagatgaaa  360
gtttgactt  ctttgccaa  atcacaaac  agcaagcaa  attcctgcc  ttctaaatg  420
agtggatat  gctggcctt  tgaaaggag  tcacaatgg  cagggcctg  ggaatgctt  480
tttatctca  tttagtgct  gtgatggca  ctttcatct  acacgtgct  ttgaagatg  540
tgatatcac  catgttgaa  aaagtgtag  tcctattcg  gatatagaa  taatacatg  600
agagcttca  cttaaagat  aggaatgac  gggcccatt  tagataaac  agaaaaggt  660
gctgtgaga  gaggagata  aaaactaaa  cccaaatat  atataatgt  caaagtaaa  720
tcctgggtt  tagatcaaa  gaacctgtt  gcttctatc  tgattggaa  gacaaagag  780
ttgaagtgt  gaataaaca  ttatttttg  cttcaaaac  aatggtcta  ttggttaat  840
tttctgaaa  agactacat  agaaagaaa  acaaatggc  gataaaaat  aaagagtgg  900
tggacaagt  tgacccagg  gccttggtc  ttcctttta  tggggcctt  gaactcaag  960
tgcaagaat  gagtgctga  gagagacag  agtatctgg  agcgaacat  acacaaagt  1020
ctttgccaa  gatcattaa  gctgggttt  cagcactcc  actaaaata  tttttcact  1080
caggcccag  tgaagtgcg  gcacggacc  tcaggaaag  gactaaggc  cctcaggct  1140
caggaaaga  tcacacaga  tttgaaaag  gattcatta  ggctgaagt  atgaaatat  1200
aagatttta  agaggaagg  tctgaaaat  cagtcaagg  tgctggaaa  tacagacaa  1260
aaggcagaa  ttatattgt  gaagatgga  atattatct  cttcaaatt  aacacacct  1320
aacaactga  gaagaaata  aatttagtt  ctgctcaga  aaacataca  cttccaaaa  1380
gcatctgat  ttttaaaaa  taaaatttc  gaaaaccaa  gggacaaat  aagttgggg  1440
gatgggaat  tttgacaaa  aaattattt  tgttttaaa  ttaaaatac  gtgtaccct  1500
tccccccaa  gaaatgcaa  ttcactaaa  gtgaacacc  ttgcttttc  tgtgattaa  1560
accctactc  aaattatag  agcttttca  gaaccatgt  actctcatg  tacttcatt  1620
atctccatc  tgtatgcca  gcctaacac  tttgacagt  agaacaatg  ggcttgctc  1680
tttttgaat  tacagataa  gcatgtttt  tagtactcc  gatgtctac  ctcaataaa  1740
catttgaca  aacc  1754



<210> 8250
<211> 166
<212> PRT
<213> Homo sapiens
<308> XP_040050
<400> 8250

Met Val Tyr Leu Val Asn Leu Ser Glu Lys Asp Tyr Ile Arg Lys Lys 
  1               5                  10                  15
Asn Lys Trp Leu Ile Lys Ile Lys Glu Trp Val Asp Lys Tyr Asp Pro 
             20                  25                  30
Gly Ala Leu Val Ile Pro Phe Ser Gly Ala Leu Glu Leu Lys Leu Gln 
         35                  40                  45
Glu Leu Ser Ala Glu Glu Arg Gln Gln Tyr Leu Glu Ala Asn Met Thr 
     50                  55                  60
Gln Ser Ala Leu Pro Lys Ile Ile Lys Ala Gly Phe Ala Ala Leu Gln 
 65                  70                  75                  80
Leu Lys Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Arg Ala Arg Thr 
                 85                  90                  95
Ile Arg Lys Gly Thr Lys Ala Pro Gln Ala Ala Gly Lys Ile His Thr 
             100                105                110
Asp Phe Glu Lys Gly Phe Ile Met Ala Glu Val Met Lys Tyr Glu Asp 
         115                120                125
Phe Lys Glu Glu Gly Ser Glu Asn Ala Val Lys Ala Ala Gly Lys Tyr 
     130                135                140
Arg Gln Gln Gly Arg Asn Tyr Ile Val Glu Asp Gly Asp Ile Ile Phe 
 145                150                155                160
Phe Lys Phe Asn Thr Pro 
                 165



<210> 8251
<211> 463
<212> DNA
<213> Rattus norvegicus
<308> U21721
<400> 8251

cccacctcc  gctgccggc  acaccggtc  ttgcagtct  ggaccccgt  cgatcttta  60
cccggtgca  gatgccccc  aaaaaggga  gagatggac  taaaccgcc  ccgatcatt  120
gaaggtttg  aacctcact  aaaattggt  ctgttggat  gccaaatgt  gggaagtct  180
ccttcttca  tgtgttaac  aatagtcag  cctcagcag  aaacttccc  ttctgcact  240
ttgacccta  cgagagcag  gtgcctgtg  cagacgaga  gtttgactt  cttttgcca  300
tgtcacaag  cagcaagca  gattcctgc  tttccttaa  gttagtggg  ttattgctg  360
gccttgtga  aggagctca  aaatgggca  gggtttggg  gaattgcct  ccttcttca  420
atttaaggg  cgtgatggg  attttcacc  taacgcgtt  ttt  463



<210> 8252
<211> 1754
<212> DNA
<213> Homo sapiens
<308> XM_040050
<400> 8252

gttccaccg  tgtcgccgc  gtagtgcgg  atgccgctc  gcggagggg  cgggcctgc  60
ttctctcct  cttcctccc  gcctctggc  gccggcagg  cctttctct  gctgctact  120
ggaccccgt  tcatagccc  ggctgagca  gatgccccc  caaaaggga  gtgatggaa  180
taaaccacc  ccaatcatt  gaagatttg  aacctcact  aaaattggt  ttgttggat  240
gccaaatgt  gggaaatct  ctttcttca  tgtattaac  aatagtcag  cttcagcag  300
aaacttccc  ttctgcact  ttgatccta  tgagagcag  gtacctgtg  cagatgaaa  360
gtttgactt  ctttgccaa  atcacaaac  agcaagcaa  attcctgcc  ttctaaatg  420
agtggatat  gctggcctt  tgaaaggag  tcacaatgg  cagggcctg  ggaatgctt  480
tttatctca  tttagtgct  gtgatggca  ctttcatct  acacgtgct  ttgaagatg  540
tgatatcac  catgttgaa  aaagtgtag  tcctattcg  gatatagaa  taatacatg  600
agagcttca  cttaaagat  aggaatgac  gggcccatt  tagataaac  agaaaaggt  660
gctgtgaga  gaggagata  aaaactaaa  cccaaatat  atataatgt  caaagtaaa  720
tcctgggtt  tagatcaaa  gaacctgtt  gcttctatc  tgattggaa  gacaaagag  780
ttgaagtgt  gaataaaca  ttatttttg  cttcaaaac  aatggtcta  ttggttaat  840
tttctgaaa  agactacat  agaaagaaa  acaaatggc  gataaaaat  aaagagtgg  900
tggacaagt  tgacccagg  gccttggtc  ttcctttta  tggggcctt  gaactcaag  960
tgcaagaat  gagtgctga  gagagacag  agtatctgg  agcgaacat  acacaaagt  1020
ctttgccaa  gatcattaa  gctgggttt  cagcactcc  actaaaata  tttttcact  1080
caggcccag  tgaagtgcg  gcacggacc  tcaggaaag  gactaaggc  cctcaggct  1140
caggaaaga  tcacacaga  tttgaaaag  gattcatta  ggctgaagt  atgaaatat  1200
aagatttta  agaggaagg  tctgaaaat  cagtcaagg  tgctggaaa  tacagacaa  1260
aaggcagaa  ttatattgt  gaagatgga  atattatct  cttcaaatt  aacacacct  1320
aacaactga  gaagaaata  aatttagtt  ctgctcaga  aaacataca  cttccaaaa  1380
gcatctgat  ttttaaaaa  taaaatttc  gaaaaccaa  gggacaaat  aagttgggg  1440
gatgggaat  tttgacaaa  aaattattt  tgttttaaa  ttaaaatac  gtgtaccct  1500
tccccccaa  gaaatgcaa  ttcactaaa  gtgaacacc  ttgcttttc  tgtgattaa  1560
accctactc  aaattatag  agcttttca  gaaccatgt  actctcatg  tacttcatt  1620
atctccatc  tgtatgcca  gcctaacac  tttgacagt  agaacaatg  ggcttgctc  1680
tttttgaat  tacagataa  gcatgtttt  tagtactcc  gatgtctac  ctcaataaa  1740
catttgaca  aacc  1754



<210> 8253
<211> 166
<212> PRT
<213> Homo sapiens
<308> XP_040050
<400> 8253

Met Val Tyr Leu Val Asn Leu Ser Glu Lys Asp Tyr Ile Arg Lys Lys 
  1               5                  10                  15
Asn Lys Trp Leu Ile Lys Ile Lys Glu Trp Val Asp Lys Tyr Asp Pro 
             20                  25                  30
Gly Ala Leu Val Ile Pro Phe Ser Gly Ala Leu Glu Leu Lys Leu Gln 
         35                  40                  45
Glu Leu Ser Ala Glu Glu Arg Gln Gln Tyr Leu Glu Ala Asn Met Thr 
     50                  55                  60
Gln Ser Ala Leu Pro Lys Ile Ile Lys Ala Gly Phe Ala Ala Leu Gln 
 65                  70                  75                  80
Leu Lys Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Arg Ala Arg Thr 
                 85                  90                  95
Ile Arg Lys Gly Thr Lys Ala Pro Gln Ala Ala Gly Lys Ile His Thr 
             100                105                110
Asp Phe Glu Lys Gly Phe Ile Met Ala Glu Val Met Lys Tyr Glu Asp 
         115                120                125
Phe Lys Glu Glu Gly Ser Glu Asn Ala Val Lys Ala Ala Gly Lys Tyr 
     130                135                140
Arg Gln Gln Gly Arg Asn Tyr Ile Val Glu Asp Gly Asp Ile Ile Phe 
 145                150                155                160
Phe Lys Phe Asn Thr Pro 
                 165



<210> 8254
<211> 6160
<212> DNA
<213> Rattus norvegicus
<308> U23146
<400> 8254

cgggccggc  ggagtagaa  agccactga  ccatgggcg  aggcagttc  accgagcag  60
ggagccccg  gcagccggc  gggagcgac  cgccgagcg  gctggtgct  agtggccat  120
ggcccgcag  tgaagcctc  ggagcagct  gagaccccg  cgacgcgga  cccgccacc  180
agctcccac  gaagaatgg  cagctgtct  ctgtcaacg  cgtagctga  caaggagat  240
tccatgtcc  agaggaaaa  caggagggg  aggaggaag  agtcgttga  gaggatgtt  300
gacagcgag  gtcagaaga  gtgagagaa  aagaccgag  tgaagaaat  gcggccaac  360
ccacagctg  tgaagatat  acaaaggat  ggcaggagg  gacatcaga  ataattgaa  420
agatccctg  ttcagaaaa  aatgtggaa  aaatggtac  gcctgctga  tcccaggct  480
atgatgttg  cttcaagaa  gtatttaaa  ttgttggtt  taaattcac  gtgaagaag  540
ataaaaatg  aaagtcaga  actgtccaa  tactcactg  caagaagga  gaaggcgaa  600
gggcagaag  ctctgtcgg  gctggagac  accaggagc  cagtgtgga  actgccgtc  660
gagagtcag  atccaaaga  agtgagctg  agcaatcca  agagaagca  gaaggcacc  720
tgaagcaag  acagagcag  acagaaatc  cccttcaag  cgaatctga  caagcggct  780
aggaagaag  caaagatga  ggagaagaa  aacaagaga  agagcccac  aagtcccca  840
aatccccga  cagcccagt  aacagtgag  caacatctt  cttcaagaa  ttcttcact  900
acggttggg  cggctggcg  aagaagacc  gcttcaaga  atcaaaaga  gatgatctg  960
aaactgccg  gaagagaaa  gagcaagag  cagaaaaag  agacgagga  gaaaaggaa  1020
agacagagc  agcctcgga  gagcaggag  cggcagaag  cacagacca  gccaggttg  1080
cagcagact  cgagaaggt  gagctgcct  tggaagacc  ggttggtga  ctggaggca  1140
cgtcagagg  gaagtgtgc  cctttggca  cggaagtgt  tgatgagaa  atggaagcc  1200
accaagaag  tgttgcaga  gtccacgtg  gcaccgtgg  gaagacaga  gaggagcag  1260
gaggaggag  agaggctga  gggggcgtg  tggtagaag  aacaggaga  tccttgccc  1320
ctgagaaac  ggctgagcc  caggaggtc  cccaggaag  tgagcctgc  gaggagctg  1380
tgaagagca  agagatgtg  gtctctgga  gagaccaca  tcaactgac  gacctaagt  1440
ctgaagaga  gacgctgcc  aaacaccca  aaggcattg  cagtgaggt  gagatgctg  1500
cctctcagg  aagaatcaa  gtacaggga  gtcccttga  gaaactctt  agtagctca  1560
gcttaaaga  gctgtctgg  aagaagcag  aggggaaac  aggaggtgg  ggagacgaa  1620
agcctggag  ataccaaca  attcacacc  aatccccag  gagtgctga  gagcagaag  1680
gagagagct  tgcgtcgtc  cccgaggag  ctgaggaga  cacgtgtct  gagaaaggg  1740
cgctggaag  accccagga  ggggaagct  aggaaggaa  tacttccga  ggagagaag  1800
agagagaag  gatcactcc  tgggcatcc  tcaaaaaga  ggtgacacc  aagaaacgg  1860
tccgaagac  ttctgagag  gacaaggag  aagagctgg  gaaggtcaa  agcgccacc  1920
tgtcctcca  tgatagcac  gtgtcagaa  tgcaagatg  agtcaaaac  gttggtgag  1980
aacaaaagc  agaggaacc  aagcgtagg  tggatactt  agtgtcttg  gaagcactg  2040
tttgtgtcg  atcatccaa  aagagagca  ggaaggcat  ctcttcaga  gatgaagga  2100
ggccaagga  actgggagg  gacagtcac  gagcagagg  ggccagcaa  gacaaagaa  2160
ccggaacag  cgctgttcc  gccagcacc  aggagcagg  ccaagcgca  ggaagttcc  2220
cacccgagc  agcgggaag  ccttccgaa  gggaaggtg  ctccacttg  gagtcattt  2280
aaagattag  cactccaag  aaaaaatcc  agtcaaaac  ggaagagaa  gccgaagac  2340
ctagtgtag  gcagttgtc  actgagatc  aaccgagta  agaagaatc  tgggtttcc  2400
ttaagaaat  catccccgg  cggcggaag  aaagggcag  cgggaagca  gaacaagcc  2460
ctgtggaag  ctcagggcc  gtggagata  atgaggacg  ccctaatgt  ccagccgtc  2520
tgcctctgt  tgagtataa  gcagtggag  gggagaaga  ggaagccca  gggaatacg  2580
agctgcccc  gctgctggg  gctgtgtac  tgtccgagg  gctcagtaa  actctggtc  2640
acactgtga  tgtcgcagt  attgatggg  ccagggcag  caccagtgt  gaagagcgg  2700
ctccttcgt  gatatccgc  tccgtaaca  aacctcttg  acacacagc  ggagaagcc  2760
tgccacctg  tgaagaggt  actgaaaaa  acatcattg  agaagaaac  cctgtgctc  2820
cccagacgt  accagaggg  aaagatgcc  atgacgaca  ggtcaccag  gaagtggat  2880
tcacctcag  agctgtgac  gccacagag  cctcagagg  tctccgtac  gaagaagtt  2940
ccgaagcat  gggggccga  gagaccaca  acatggtgt  cgcagtttc  cagctgact  3000
actccccag  caccacaga  gaagccacc  cagttcagg  ggtagagag  ggtgtgcta  3060
atacagaag  agaggagcg  cagacgcag  ccatcctcc  agccgttgc  gacaaggtg  3120
aagaggagt  ccaggtgcc  gcaacccag  ctgtgcaga  aacggggtc  aaagcactg  3180
agaaggttg  ggaggtaga  gaggactcc  aagtgctgg  ttcggagaa  gagaaggac  3240
ttatgccga  aggacccgt  caggaagct  gagctgagc  tcttgcaca  ggctctgag  3300
ctggacagg  tactccaga  agccttgaa  ttcctgaag  cacggcaga  gtagaccat  3360
tcgccacgt  ccaggttat  aagctccag  agctgatgg  acaggccgt  gcccctgag  3420
catccgaaa  cttgacaga  agtgagaca  atggaagca  tcccttagc  gattcagac  3480
ctgcagatg  gacacagca  gatgaaacc  ttgacagcc  ggacagtaa  gccactgca  3540
ctgtcaggc  gtcacaggt  acagaagaa  aggcggcta  tgctcagaa  gaggagcct  3600
cgacactac  taataatgt  ccagcccag  aagaacatg  ggaagaacc  ggaagagat  3660
ttcttgaac  tacacagca  gagcttact  ctgcagccg  gcccgttct  gcaaagact  3720
aggtgggtc  agagggtga  gttgactgg  tggatggag  aaaagtcaa  gaagaacag  3780
aggtgtttg  acactctgg  cccaacagt  aaaaggctg  tgatgtgac  tatgacagt  3840
aagtgatgg  agtggccgg  tgtcaggaa  aggagagta  tgaagtgca  agtcttagc  3900
tggaggagg  agagatgga  actgacgtt  aaaaggaga  aagggagac  aagccagag  3960
aagtgagtg  agaaggtga  caggaaaca  ccgctcctg  gcatgaagg  acctacggg  4020
agccagtcc  gacacttga  atgcccagc  cagagaggg  gaaggcact  ggaagcctt  4080
gaggaagcc  ttctctccc  gaccaagac  aagcaggtt  catagaggt  caagttcaa  4140
gcctggaca  aacagtcac  caaacagca  aagctgtgg  aaaggtcat  gaaacggtt  4200
tgatttcag  gacaggtga  agtccagag  gtgtaggtg  acacttatt  ccagctgag  4260
agtcctctg  aacgggtgg  cactggact  ttcagcatg  agaggacac  gtacccctg  4320
ggcctgagt  tcaggcaga  tccatccca  tcatagtaa  tcctgctcc  gaaagcacc  4380
tacatcctg  cctacaagg  gaaataagc  catcccaga  agagcgatc  gaggaagag  4440
acaagccag  tgctggtcc  gatgctgac  gcaaggaga  tacagcaat  gaaaaagtc  4500
tcaaggctg  acctgagat  ctggaactt  agagtaaga  caacaagat  gtgctgaac  4560
tcattcaga  agccgttga  cagttcgca  gtacagaaa  agcccccga  actcatgct  4620
atgattcac  gacccaggt  cctgcatgc  ggcttgaca  cagggagcc  aacagatgc  4680
ggacaaaaa  gaaagatgc  aagatgaaa  acccagtgc  gcagcccag  gaggacttg  4740
aagtcctga  cgttctgga  gcatgggct  agcctcgga  atgcttgcc  cgcttgcag  4800
tgaaagcgc  ggtgtcaaa  taagcattg  gaagctgcc  cctcaaccc  aagatccaa  4860
aggagcatg  tgctgatgg  cctcagctc  aaagcttag  ccaggcaga  gccagtgcc  4920
ctggaaacc  aaccaaaga  tccccagac  ccaacggac  aaagctaac  gaggagggc  4980
atcccccaa  agttgaggt  caggaagaa  aaatgtcta  caagtcagt  aaagagaac  5040
aggcccagg  agaagagga  ctgcaggag  caaagggag  cctggcaga  tcctaagat  5100
ttagttgct  attgtacat  tgtaagacc  gaatgtgaa  acaagtcac  gaacaagat  5160
ctgctgttg  gaccttgag  ccaagattt  agagcccat  agatccaga  agcagggcc  5220
tccaatgat  tccacccag  agagcaccc  gacaattct  aggcttcat  gggagctag  5280
gccagctaa  atttcctcg  ttcaagact  cctttgatt  gccccttga  gccgtccgt  5340
tatttctaa  atttcctcg  ttcaagact  cctttgatt  gccccttga  gccgtccgt  5400
tatttcgga  ttaaggtcc  gcgttctca  cctggaacc  attctgcca  acctagttc  5460
acttctcaa  ctggagcat  ctcctttat  tatttatat  tatgtttta  gtagtcctc  5520
tcctgtacc  attgtatat  tttttctaa  gtttaagca  atgcttttt  tattatgca  5580
tatataacg  gtgtgcagc  atagcgacg  tttgaaaag  tccaagcct  aactgtaac  5640
tgcagcaaa  agataacat  cctggcaag  agagacaag  cttttttaa  gtttactga  5700
gcttagatc  gtgggcttc  agtcctctg  aagtggttg  tttcctatg  acagcgagc  5760
cagaaataa  aaccccatt  tgaaacatc  aggatgtcc  aatattacc  tgatttttt  5820
ccccctttt  gctaatcca  tccaggttg  aaagaagtc  cctctgtgt  agattaagc  5880
ctgtctctt  atgatatgg  caaatgagt  tgcctaagg  catgagatg  ttcctaatg  5940
agaaggaat  tgttgtacg  ttttttgat  gtactcttc  atgctggac  gaattcata  6000
gcagatcga  gtgagtcct  ttctttaca  atggtattt  gatagatac  ggagtttgt  6060
tgtgttata  ctgtgcccc  tctttaaga  caatgttgc  ttatgttcc  ttggataaa  6120
tgtgatttg  caactgatt  aaataaaca  atttgactac  6160



<210> 8255
<211> 1596
<212> PRT
<213> Rattus norvegicus
<308> AAA79517
<400> 8255

Met Gly Ala Gly Ser Ser Thr Glu Gln Arg Ser Pro Glu Gln Pro Ala 
  1               5                  10                  15
Gly Ser Asp Thr Pro Ser Glu Leu Val Leu Ser Gly His Gly Pro Ala 
             20                  25                  30
Ala Glu Ala Ser Gly Ala Ala Gly Asp Pro Ala Asp Ala Asp Pro Ala 
         35                  40                  45
Thr Lys Leu Pro Gln Lys Asn Gly Gln Leu Ser Ser Val Asn Gly Val 
     50                  55                  60
Ala Glu Gln Gly Asp Val His Val Gln Glu Glu Asn Gln Glu Gly Gln 
 65                  70                  75                  80
Glu Glu Glu Val Val Asp Glu Asp Val Gly Gln Arg Glu Ser Glu Asp 
                 85                  90                  95
Val Arg Glu Lys Asp Arg Val Glu Glu Met Ala Ala Asn Ser Thr Ala 
             100                105                110
Val Glu Asp Ile Thr Lys Asp Gly Gln Glu Glu Thr Ser Glu Ile Ile 
         115                120                125
Glu Gln Ile Pro Ala Ser Glu Asn Asn Val Glu Glu Met Val Gln Pro 
     130                135                140
Ala Glu Ser Gln Ala Asn Asp Val Gly Phe Lys Lys Val Phe Lys Phe 
 145                150                155                160
Val Gly Phe Lys Phe Thr Val Lys Lys Asp Lys Asn Glu Lys Ser Asp 
                 165                170                175
Thr Val Gln Leu Leu Thr Val Lys Lys Asp Glu Gly Glu Gly Ala Glu 
             180                185                190
Ala Ser Val Gly Ala Gly Asp His Gln Glu Pro Ser Val Glu Thr Ala 
         195                200                205
Val Gly Glu Ser Ala Ser Lys Glu Ser Glu Leu Lys Gln Ser Thr Glu 
     210                215                220
Lys Gln Glu Gly Thr Leu Lys Gln Glu Gln Ser Ser Thr Glu Ile Pro 
 225                230                235                240
Leu Gln Ala Glu Ser Asp Gln Ala Ala Glu Glu Glu Ala Lys Asp Glu 
                 245                250                255
Gly Glu Glu Lys Gln Glu Lys Glu Pro Thr Lys Ser Pro Glu Ser Pro 
             260                265                270
Ser Ser Pro Val Asn Ser Glu Thr Thr Ser Ser Phe Lys Lys Phe Phe 
         275                280                285
Thr His Gly Trp Ala Gly Trp Arg Lys Lys Thr Ser Phe Lys Lys Ser 
     290                295                300
Lys Glu Asp Asp Leu Glu Thr Ala Glu Lys Arg Lys Glu Gln Glu Ala 
 305                310                315                320
Glu Lys Val Asp Glu Glu Glu Lys Glu Lys Thr Glu Pro Ala Ser Glu 
                 325                330                335
Glu Gln Glu Pro Ala Glu Asp Thr Asp Gln Ala Arg Leu Ser Ala Asp 
             340                345                350
Tyr Glu Lys Val Glu Leu Pro Leu Glu Asp Gln Val Gly Asp Leu Glu 
         355                360                365
Ala Ser Ser Glu Glu Lys Cys Ala Pro Leu Ala Thr Glu Val Phe Asp 
     370                375                380
Glu Lys Met Glu Ala His Gln Glu Val Val Ala Glu Val His Val Ser 
 385                390                395                400
Thr Val Glu Lys Thr Glu Glu Glu Gln Gly Gly Gly Gly Glu Ala Glu 
                 405                410                415
Gly Gly Val Val Val Glu Gly Thr Gly Glu Ser Leu Pro Pro Glu Lys 
             420                425                430
Leu Ala Glu Pro Gln Glu Val Pro Gln Glu Ala Glu Pro Ala Glu Glu 
         435                440                445
Leu Met Lys Ser Arg Glu Met Cys Val Ser Gly Gly Asp His Thr Gln 
     450                455                460
Leu Thr Asp Leu Ser Pro Glu Glu Lys Thr Leu Pro Lys His Pro Glu 
 465                470                475                480
Gly Ile Val Ser Glu Val Glu Met Leu Ser Ser Gln Glu Arg Ile Lys 
                 485                490                495
Val Gln Gly Ser Pro Leu Lys Lys Leu Phe Ser Ser Ser Gly Leu Lys 
             500                505                510
Lys Leu Ser Gly Lys Lys Gln Lys Gly Lys Arg Gly Gly Gly Gly Asp 
         515                520                525
Glu Glu Pro Gly Glu Tyr Gln His Ile His Thr Glu Ser Pro Glu Ser 
     530                535                540
Ala Asp Glu Gln Lys Gly Glu Ser Ser Ala Ser Ser Pro Glu Glu Pro 
 545                550                555                560
Glu Glu Thr Thr Cys Leu Glu Lys Gly Pro Leu Glu Ala Pro Gln Asp 
                 565                570                575
Gly Glu Ala Glu Glu Gly Thr Thr Ser Asp Gly Glu Lys Lys Arg Glu 
             580                585                590
Gly Ile Thr Pro Trp Ala Ser Phe Lys Lys Met Val Thr Pro Lys Lys 
         595                600                605
Arg Val Arg Arg Pro Ser Glu Ser Asp Lys Glu Glu Glu Leu Glu Lys 
     610                615                620
Val Lys Ser Ala Thr Leu Ser Ser Thr Asp Ser Thr Val Ser Glu Met 
 625                630                635                640
Gln Asp Glu Val Lys Thr Val Gly Glu Glu Gln Lys Pro Glu Glu Pro 
                 645                650                655
Lys Arg Arg Val Asp Thr Ser Val Ser Trp Glu Ala Leu Ile Cys Val 
             660                665                670
Gly Ser Ser Lys Lys Arg Ala Arg Lys Ala Ser Ser Ser Asp Asp Glu 
         675                680                685
Gly Gly Pro Arg Thr Leu Gly Gly Asp Ser His Arg Ala Glu Glu Ala 
     690                695                700
Ser Lys Asp Lys Glu Ala Gly Thr Asp Ala Val Pro Ala Ser Thr Gln 
 705                710                715                720
Glu Gln Asp Gln Ala Gln Gly Ser Ser Ser Pro Glu Pro Ala Gly Ser 
                 725                730                735
Pro Ser Glu Gly Glu Gly Val Ser Thr Trp Glu Ser Phe Lys Arg Leu 
             740                745                750
Val Thr Pro Arg Lys Lys Ser Lys Ser Lys Leu Glu Glu Lys Ala Glu 
         755                760                765
Asp Ser Ser Val Glu Gln Leu Ser Thr Glu Ile Glu Pro Ser Arg Glu 
     770                775                780
Glu Ser Trp Val Ser Ile Lys Lys Phe Ile Pro Gly Arg Arg Lys Lys 
 785                790                795                800
Arg Ala Asp Gly Lys Gln Glu Gln Ala Thr Val Glu Asp Ser Gly Pro 
                 805                810                815
Val Glu Ile Asn Glu Asp Asp Pro Asn Val Pro Ala Val Val Pro Leu 
             820                825                830
Ser Glu Tyr Asn Ala Val Glu Arg Glu Lys Met Glu Ala Gln Gly Asn 
         835                840                845
Thr Glu Leu Pro Gln Leu Leu Gly Ala Val Tyr Val Ser Glu Glu Leu 
     850                855                860
Ser Lys Thr Leu Val His Thr Val Ser Val Ala Val Ile Asp Gly Thr 
 865                870                875                880
Arg Ala Val Thr Ser Val Glu Glu Arg Ser Pro Ser Trp Ile Ser Ala 
                 885                890                895
Ser Val Thr Glu Pro Leu Glu His Thr Ala Gly Glu Ala Met Pro Pro 
             900                905                910
Val Glu Glu Val Thr Glu Lys Asp Ile Ile Ala Glu Glu Thr Pro Val 
         915                920                925
Leu Thr Gln Thr Leu Pro Glu Gly Lys Asp Ala His Asp Asp Met Val 
     930                935                940
Thr Ser Glu Val Asp Phe Thr Ser Glu Ala Val Thr Ala Thr Glu Thr 
 945                950                955                960
Ser Glu Ala Leu Arg Thr Glu Glu Val Thr Glu Ala Ser Gly Ala Glu 
                 965                970                975
Glu Thr Thr Asp Met Val Ser Ala Val Ser Gln Leu Thr Asp Ser Pro 
             980                985                990
Asp Thr Thr Glu Glu Ala Thr Pro Val Gln Glu Val Glu Ser Gly Val 
         995                1000                1005
Leu Asp Thr Glu Glu Glu Glu Arg Gln Thr Gln Ala Ile Leu Gln Ala 
     1010                1015                1020
Val Ala Asp Lys Val Lys Glu Glu Ser Gln Val Pro Ala Thr Gln Thr 
 1025                1030                1035                1040
Val Gln Arg Thr Gly Ser Lys Ala Leu Glu Lys Val Glu Glu Val Glu 
                 1045                1050                1055
Glu Asp Ser Glu Val Leu Ala Ser Glu Lys Glu Lys Asp Val Met Pro 
             1060                1065                1070
Lys Gly Pro Val Gln Glu Ala Gly Ala Glu His Leu Ala Gln Gly Ser 
         1075                1080                1085
Glu Thr Gly Gln Ala Thr Pro Glu Ser Leu Glu Val Pro Glu Val Thr 
     1090                1095                1100
Ala Asp Val Asp His Val Ala Thr Cys Gln Val Ile Lys Leu Gln Gln 
 1105                1110                1115                1120
Leu Met Glu Gln Ala Val Ala Pro Glu Ser Ser Glu Thr Leu Thr Asp 
                 1125                1130                1135
Ser Glu Thr Asn Gly Ser Thr Pro Leu Ala Asp Ser Asp Thr Ala Asp 
             1140                1145                1150
Gly Thr Gln Gln Asp Glu Thr Ile Asp Ser Gln Asp Ser Lys Ala Thr 
         1155                1160                1165
Ala Ala Val Arg Gln Ser Gln Val Thr Glu Glu Glu Ala Ala Thr Ala 
     1170                1175                1180
Gln Lys Glu Glu Pro Ser Thr Leu Pro Asn Asn Val Pro Ala Gln Glu 
 1185                1190                1195                1200
Glu His Gly Glu Glu Pro Gly Arg Asp Val Leu Glu Pro Thr Gln Gln 
                 1205                1210                1215
Glu Leu Thr Ala Ala Ala Val Pro Val Leu Ala Lys Thr Glu Val Gly 
             1220                1225                1230
Gln Glu Gly Glu Val Asp Trp Leu Asp Gly Glu Lys Val Lys Glu Glu 
         1235                1240                1245
Gln Glu Val Phe Val His Ser Gly Pro Asn Ser Gln Lys Ala Ala Asp 
     1250                1255                1260
Val Thr Tyr Asp Ser Glu Val Met Gly Val Ala Gly Cys Gln Glu Lys 
 1265                1270                1275                1280
Glu Ser Thr Glu Val Gln Ser Leu Ser Leu Glu Glu Gly Glu Met Glu 
                 1285                1290                1295
Thr Asp Val Glu Lys Glu Lys Arg Glu Thr Lys Pro Glu Gln Val Ser 
             1300                1305                1310
Glu Glu Gly Glu Gln Glu Thr Ala Ala Pro Glu His Glu Gly Thr Tyr 
         1315                1320                1325
Gly Lys Pro Val Leu Thr Leu Asp Met Pro Ser Ser Glu Arg Gly Lys 
     1330                1335                1340
Ala Leu Gly Ser Leu Gly Gly Ser Pro Ser Leu Pro Asp Gln Asp Lys 
 1345                1350                1355                1360
Ala Gly Cys Ile Glu Val Gln Val Gln Ser Leu Asp Thr Thr Val Thr 
                 1365                1370                1375
Gln Thr Ala Glu Ala Val Glu Lys Val Ile Glu Thr Val Val Ile Ser 
             1380                1385                1390
Glu Thr Gly Glu Ser Pro Glu Cys Val Gly Ala His Leu Leu Pro Ala 
         1395                1400                1405
Glu Lys Ser Ser Ala Thr Gly Gly His Trp Thr Leu Gln His Ala Glu 
     1410                1415                1420
Asp Thr Val Pro Leu Gly Pro Glu Ser Gln Ala Glu Ser Ile Pro Ile 
 1425                1430                1435                1440
Ile Val Thr Pro Ala Pro Glu Ser Thr Leu His Pro Asp Leu Gln Gly 
                 1445                1450                1455
Glu Ile Ser Ala Ser Gln Arg Glu Arg Ser Glu Glu Glu Asp Lys Pro 
             1460                1465                1470
Asp Ala Gly Pro Asp Ala Asp Gly Lys Glu Ser Thr Ala Ile Glu Lys 
         1475                1480                1485
Val Leu Lys Ala Glu Pro Glu Ile Leu Glu Leu Glu Ser Lys Ser Asn 
     1490                1495                1500
Lys Ile Val Leu Asn Val Ile Gln Thr Ala Val Asp Gln Phe Ala Arg 
 1505                1510                1515                1520
Thr Glu Thr Ala Pro Glu Thr His Ala Tyr Asp Ser Gln Thr Gln Val 
                 1525                1530                1535
Pro Ala Cys Arg Leu Asp Ser Arg Glu Pro Asn Arg Cys Trp Thr Lys 
             1540                1545                1550
Met Lys Asp Ala Lys Met Lys His Pro Val Pro Gln Pro Arg Glu Asp 
         1555                1560                1565
Leu Gln Val Leu Thr Val Leu Glu Ala Trp Ala Gln Pro Arg Lys Cys 
     1570                1575                1580
Leu Pro Arg Leu Gln Leu Lys Ala Pro Val Ser Lys 
 1585                1590                1595



<210> 8256
<211> 817
<212> DNA
<213> Rattus norvegicus
<308> U23407
<400> 8256

cggaattcc  atctgttct  caaagggga  agcaaggta  ctttaggct  aaggactcg  60
cgtccagta  tctagttga  gatctaaag  gaaagccac  ttgctgcca  tatgcctaa  120
ttttctggc  actggaaga  catccgatc  gaaaacttt  aagaaatgc  aaaagctct  180
ggggtgaac  tgatgatga  gaagattgc  gtggctgca  cctccaagc  agcagtgga  240
atcaaacag  agaatgatg  cactttcta  atcaaaacc  ccaccactg  tcgaaccac  300
gagattaac  tcaagatcg  ggaggaatt  gaagagcag  ctgtggatg  gagaccctg  360
aagagtttg  tgaaatggg  gagtgaaaa  aaaatggtg  gcgaacaga  gcttctgaa  420
ggggagggc  ccaaaacct  ctggagccg  gaactgacc  atgatggag  gctaatcct  480
accatgaca  cagacgacg  tgtatgcac  agggtctac  tccgagagt  agtgcctat  540
tcccaagaa  ttcttctgg  aggcccacc  aacctccct  cctcccatg  ccattttac  600
aactagctc  ccccttact  ctgagggtc  ctctctatg  cagagaggg  cagactacc  660
aagctcaga  cccttccat  tgcctggtc  gaagtccca  ctccatacc  ggatccttc  720
tggaagaga  tgtctctct  gcctctact  tttatcctt  tagtccaag  gatttagaa  780
atttattgg  taattttat  aaaatgttt  aaaatgg  817



<210> 8257
<211> 138
<212> PRT
<213> Rattus norvegicus
<308> P51673
<400> 8257

Pro Asn Phe Ser Gly Asn Trp Lys Ile Ile Arg Ser Glu Asn Phe Glu 
  1               5                  10                  15
Glu Met Leu Lys Ala Leu Gly Val Asn Met Met Met Arg Lys Ile Ala 
             20                  25                  30
Val Ala Ala Ala Ser Lys Pro Ala Val Glu Ile Lys Gln Glu Asn Asp 
         35                  40                  45
Asp Thr Phe Tyr Ile Lys Thr Ser Thr Thr Val Arg Thr Thr Glu Ile 
     50                  55                  60
Asn Phe Lys Ile Gly Glu Glu Phe Glu Glu Gln Thr Val Asp Gly Arg 
 65                  70                  75                  80
Pro Cys Lys Ser Leu Val Lys Trp Glu Ser Glu Asn Lys Met Val Cys 
                 85                  90                  95
Glu Gln Arg Leu Leu Lys Gly Glu Gly Pro Lys Thr Ser Trp Ser Arg 
             100                105                110
Glu Leu Thr Asn Asp Gly Glu Leu Ile Leu Thr Met Thr Ala Asp Asp 
         115                120                125
Val Val Cys Thr Arg Val Tyr Val Arg Glu 
     130                135



<210> 8258
<211> 924
<212> DNA
<213> Homo sapiens
<308> M68867
<400> 8258

cctgacgac  cggcgacgg  gacgtctct  ttgactaaa  gacagtgtc  agtgctcca  60
cctaggagt  tacggggac  gcctcccgc  ccgccacca  gcccaactt  tctggcaac  120
ggaaaatca  ccgatcgga  aacttcgag  aattgctca  agtgctggg  gtgaatgtg  180
tgctgagga  gattgctgt  gctgcagcg  ccaagccag  agtggagat  aaacaggag  240
gagacactt  ctacatcaa  acctccacc  ccgtgcgca  cacagagat  aacttcaag  300
ttggggagg  gtttgagga  cagactgtg  atgggaggc  ctgtaagag  ctggtgaaa  360
gggagagtg  gaataaaat  gtctgtgag  agaagctcc  gaagggaga  ggccccaag  420
cctcgtgga  cagagaact  accaacgat  gggaactga  cctgaccat  acggcggat  480
acgttgtgt  caccagggt  tacgtccga  agtgagtgg  cacaggtag  accgcggcc  540
aagcccacc  ctggccatg  tcaccgccc  gcttcactg  cccctccgt  ccaccccct  600
cttctagga  agcgctccc  ttaccccag  cacttctgg  ggtcactgg  atgcctctt  660
cagggtctt  ctttctttg  cctcttctc  cctccccta  accaacaaa  aggaatggc  720
gcaagagcc  agatcaccc  ttccgggtt  actccccgc  tccccaagt  agcagtcct  780
gccccaaac  agcccagag  agggtctct  taaagggga  ttgagggcc  gagcaggaa  840
gactggccc  ctagcttct  ccctttgtc  ctgtagcct  tacagttta  aatatttat  900
tgttaattt  attaaaatg  ttta  924



<210> 8259
<211> 137
<212> PRT
<213> Homo sapiens
<308> P29373
<400> 8259

Pro Asn Phe Ser Gly Asn Trp Lys Ile Ile Arg Ser Glu Asn Phe Glu 
  1               5                  10                  15
Glu Leu Leu Lys Val Leu Gly Val Asn Val Met Leu Arg Lys Ile Ala 
             20                  25                  30
Val Ala Ala Ala Ser Lys Pro Ala Val Glu Ile Lys Gln Glu Gly Asp 
         35                  40                  45
Thr Phe Tyr Ile Lys Thr Ser Thr Thr Val Arg Thr Thr Glu Ile Asn 
     50                  55                  60
Phe Lys Val Gly Glu Glu Phe Glu Glu Gln Thr Val Asp Gly Arg Pro 
 65                  70                  75                  80
Cys Lys Ser Leu Val Lys Trp Glu Ser Glu Asn Lys Met Val Cys Glu 
                 85                  90                  95
Gln Lys Leu Leu Lys Gly Glu Gly Pro Lys Thr Ser Trp Thr Arg Glu 
             100                105                110
Leu Thr Asn Asp Gly Glu Leu Ile Leu Thr Met Thr Ala Asp Asp Val 
         115                120                125
Val Cys Thr Arg Val Tyr Val Arg Glu 
     130                135



<210> 8260
<211> 1392
<212> DNA
<213> Rattus norvegicus
<308> U23769
<400> 8260

ccgggatcc  tgcgcgccg  ggtgttctg  gccttgccg  tctgttccc  ccgattgtg  60
ctagcaatg  ccacccagc  gattgttct  cagggcccg  gaccctggg  tttccgact  120
gtgggcggc  aggactttg  gcaacctct  gccatttcc  gggtcactc  cgggagcaa  180
gctgctata  ctaacttat  cataggaga  ttgatcaca  ccattgatg  ggaagatac  240
agcagtatg  cacacttgg  agctcagaa  aaaatcaag  gctgcgtag  caacatgac  300
ctcacagta  ccaggtctg  gcagaagat  tggtctcct  tagtgaccg  ggaggggaa  360
cgtcacccc  acaagatga  tttagcgtc  gaaccccaa  aagtcctgc  catcggaag  420
gcccacaac  gtagtgcta  gccatttac  gcctcacct  ctcctggca  ccgggtcat  480
acaaaccag  acaacagcc  taccggcct  tactcatct  aaaacatct  taacttcaa  540
aatgcagtg  agtcaaaga  ctcagccag  ggggaggag  cgaacagca  gccctcggc  600
cagcctcat  cctccggcg  ccttatcat  gacaaggaa  ccgaagttt  caagatgct  660
caggagaag  aagagttaa  cgagccccc  aaacagtcc  catcattcc  ggttctgca  720
gagatcctg  agtcggatg  gaaagggga  cccaacaag  catcaggat  tagaagtgt  780
aaagctcca  tcaccaaag  ggctgcatc  gttggaaat  ctcagaagc  gcccatctg  840
gacaaatgt  gaaccggca  tgttggtgt  tttgtgaag  tgagggacc  tcatcccca  900
cctgaatgt  atgtgtgca  cgactgtgg  atcaacctg  aacagaagg  ccatttctt  960
gtaggggat  agatttatt  tgaaaagca  gcccgggag  gggtcacac  acctgaggg  1020
tatgatgtg  tcacagtgt  ccccaagtg  tcgagagga  ctgccctgt  tgctgccct  1080
cagcctgcc  gctgcacct  gttgtcaga  tgttctggt  ctctcctcc  tgacagtcc  1140
gtgcttagt  ttagtcctg  tcagtaaac  ttgagtttc  cctgtactg  ctgaccctg  1200
ctggcagtg  gacacctgc  tttacatta  cgggaggtg  ttttgtccc  gtcccctca  1260
ccacaccac  atgcacctt  ttcccttgg  gtcttccct  ctgaaaatg  acattggtc  1320
cattggaat  aagccaaat  ttttatctc  gatgttact  tgttttact  aataaattt  1380
gactttaaa  cc  1392



<210> 8261
<211> 327
<212> PRT
<213> Rattus norvegicus
<308> P52944
<400> 8261

Met Thr Thr Gln Gln Ile Val Leu Gln Gly Pro Gly Pro Trp Gly Phe 
  1               5                  10                  15
Arg Leu Val Gly Gly Lys Asp Phe Glu Gln Pro Leu Ala Ile Ser Arg 
             20                  25                  30
Val Thr Pro Gly Ser Lys Ala Ala Ile Ala Asn Leu Cys Ile Gly Asp 
         35                  40                  45
Leu Ile Thr Ala Ile Asp Gly Glu Asp Thr Ser Ser Met Thr His Leu 
     50                  55                  60
Glu Ala Gln Asn Lys Ile Lys Gly Cys Val Asp Asn Met Thr Leu Thr 
 65                  70                  75                  80
Val Ser Arg Ser Glu Gln Lys Ile Trp Ser Pro Leu Val Thr Glu Glu 
                 85                  90                  95
Gly Lys Arg His Pro Tyr Lys Met Asn Leu Ala Ser Glu Pro Gln Glu 
             100                105                110
Val Leu His Ile Gly Ser Ala His Asn Arg Ser Ala Met Pro Phe Thr 
         115                120                125
Ala Ser Pro Ala Pro Gly Thr Arg Val Ile Thr Asn Gln Tyr Asn Ser 
     130                135                140
Pro Thr Gly Leu Tyr Ser Ser Glu Asn Ile Ser Asn Phe Asn Asn Ala 
 145                150                155                160
Val Glu Ser Lys Thr Ser Ala Ser Gly Glu Glu Ala Asn Ser Arg Pro 
                 165                170                175
Ser Ala Gln Pro His Pro Ser Gly Gly Leu Ile Ile Asp Lys Glu Ser 
             180                185                190
Glu Val Tyr Lys Met Leu Gln Glu Lys Gln Glu Leu Asn Glu Pro Pro 
         195                200                205
Lys Gln Ser Thr Ser Phe Leu Val Leu Gln Glu Ile Leu Glu Ser Asp 
     210                215                220
Gly Lys Gly Asp Pro Asn Lys Pro Ser Gly Phe Arg Ser Val Lys Ala 
 225                230                235                240
Pro Val Thr Lys Val Ala Ala Ser Val Gly Asn Ala Gln Lys Leu Pro 
                 245                250                255
Ile Cys Asp Lys Cys Gly Thr Gly Ile Val Gly Val Phe Val Lys Leu 
             260                265                270
Arg Asp His His Pro His Pro Glu Cys Tyr Val Cys Thr Asp Cys Gly 
         275                280                285
Ile Asn Leu Lys Gln Lys Gly His Phe Phe Val Gly Asp Gln Ile Tyr 
     290                295                300
Cys Glu Lys His Ala Arg Glu Arg Val Thr Pro Pro Glu Gly Tyr Asp 
 305                310                315                320
Val Val Thr Val Phe Pro Lys 
                 325



<210> 8262
<211> 1462
<212> DNA
<213> Homo sapiens
<308> BC000915
<400> 8262

gcccgcgcc  cgccgctct  tctccgaca  ctgccgggg  tgccctgca  gctgttccg  60
gcgtcctgc  cgtctgtcc  cgcgggtcg  cgcccgcca  agccgcgcc  tgaccaccc  120
gcagataga  ctccagggc  cggggccgt  gggcttccg  ctcgtgggc  gcaaggact  180
cgagcagcc  ctcgccatt  cccgggtca  tcctggaag  aaggcggct  tagctaatt  240
atgtattgg  gatgtaatc  cagccattg  tggggaaaa  actagcaat  tgacacact  300
ggaagctca  aacagaatc  aaggctgca  agacaactt  actctcact  tagccagat  360
tgaacataa  gtctggtct  ctctggtga  ggaggaagg  aagcgtcat  catacaaga  420
gaatttagc  tctgaaccc  aggaggtcc  gcacatagg  agcgcccac  accgaagtg  480
catgccctt  accgcctcg  ctgcctcca  cactactgc  agggtcatc  caaaccagt  540
caacaaccc  gctggcctc  actcttctg  aaatatctc  aacttcaac  atgccctgg  600
gtcaaagac  gctgccagc  gggtggagg  gaacagcag  cccttagac  atgctcagc  660
tccaagcag  cttgtcatc  acaaagaat  tgaagttta  aagatgctt  aggagaaac  720
ggagttgaa  gagcccccg  aacagtcca  gtctttctt  gttttgcag  aaatcctgg  780
gtctgaaga  aaaggggat  ccaacaagc  ctcaggatt  agaagtgtt  aagctcctg  840
cactaaagt  gctgcgtcg  ttggaaatg  tcagaagtt  cctatgtgt  acaaatgtg  900
cactgggat  gttggtgtg  ttgtgaagc  gcgggaccg  caccgccac  ctgagtgtt  960
tgtgtgcac  gactgtggc  ccaacctga  acagaaggg  catttcttt  tggaggatc  1020
aatctactg  gagaagcat  cccgggagc  agtcacacc  cctgagggt  atgaagtgg  1080
cactgtgtt  cccaagtga  ccagcagat  tgaccactg  tctccagca  gcctctgct  1140
cagcttttt  tctcagtgt  ctggccctc  cctctcttg  aagttctct  cttactttg  1200
ttttccctc  gcttgtaaa  cattgagtc  cctccctgc  ttggttaat  gactcacac  1260
agctgtgcg  tgcccgctt  tacaattaa  ggaaaactg  tttgttcag  gtcaccttg  1320
cagcaacac  gtgtccctt  gccccaccg  tcttctctg  tgcatttgg  catcagcca  1380
atttgaacc  aatcaaata  aacgtgtct  acactgatt  tgtttttac  caataaatg  1440
atagactac  aaaaaaaaa  aa  1462



<210> 8263
<211> 329
<212> PRT
<213> Homo sapiens
<308> O00151
<400> 8263

Met Thr Thr Gln Gln Ile Asp Leu Gln Gly Pro Gly Pro Trp Gly Phe 
  1               5                  10                  15
Arg Leu Val Gly Gly Lys Asp Phe Glu Gln Pro Leu Ala Ile Ser Arg 
             20                  25                  30
Val Thr Pro Gly Ser Lys Ala Ala Leu Ala Asn Leu Cys Ile Gly Asp 
         35                  40                  45
Val Ile Thr Ala Ile Asp Gly Glu Asn Thr Ser Asn Met Thr His Leu 
     50                  55                  60
Glu Ala Gln Asn Arg Ile Lys Gly Cys Thr Asp Asn Leu Thr Leu Thr 
 65                  70                  75                  80
Val Ala Arg Ser Glu His Lys Val Trp Ser Pro Leu Val Thr Glu Glu 
                 85                  90                  95
Gly Lys Arg His Pro Tyr Lys Met Asn Leu Ala Ser Glu Pro Gln Glu 
             100                105                110
Val Leu His Ile Gly Ser Ala His Asn Arg Ser Ala Met Pro Phe Thr 
         115                120                125
Ala Ser Pro Ala Ser Ser Thr Thr Ala Arg Val Ile Thr Asn Gln Tyr 
     130                135                140
Asn Asn Pro Ala Gly Leu Tyr Ser Ser Glu Asn Ile Ser Asn Phe Asn 
 145                150                155                160
Asn Ala Leu Glu Ser Lys Thr Ala Ala Ser Gly Val Glu Ala Asn Ser 
                 165                170                175
Arg Pro Leu Asp His Ala Gln Pro Pro Ser Ser Leu Val Ile Asp Lys 
             180                185                190
Glu Ser Glu Val Tyr Lys Met Leu Gln Glu Lys Gln Glu Leu Asn Glu 
         195                200                205
Pro Pro Lys Gln Ser Thr Ser Phe Leu Val Leu Gln Glu Ile Leu Glu 
     210                215                220
Ser Glu Glu Lys Gly Asp Pro Asn Lys Pro Ser Gly Phe Arg Ser Val 
 225                230                235                240
Lys Ala Pro Val Thr Lys Val Ala Ala Ser Ile Gly Asn Ala Gln Lys 
                 245                250                255
Leu Pro Met Cys Asp Lys Cys Gly Thr Gly Ile Val Gly Val Phe Val 
             260                265                270
Lys Leu Arg Asp Arg His Arg His Pro Glu Cys Tyr Val Cys Thr Asp 
         275                280                285
Cys Gly Thr Asn Leu Lys Gln Lys Gly His Phe Phe Val Glu Asp Gln 
     290                295                300
Ile Tyr Cys Glu Lys His Ala Arg Glu Arg Val Thr Pro Pro Glu Gly 
 305                310                315                320
Tyr Glu Val Val Thr Val Phe Pro Lys 
                 325



<210> 8264
<211> 793
<212> DNA
<213> Rattus norvegicus
<308> U24489
<400> 8264

tcaaagacc  ccaccatct  cctcaatgg  aaccgcgag  ggcccttgg  tgtgttttg  60
gacatgcag  ctgacggag  aggttggct  gtgttccag  gccgcatgg  cggacagac  120
gacttctgg  gagactggg  ggagtacgc  catggtttt  ggaacatct  cagggaatt  180
tggctgggc  atgaggccc  tcacagcct  acgcaggct  gagactact  tatgcgtgt  240
gacctgcgg  ccggaaagg  agccgtgtt  gcccagtat  acttcttcc  agtagactc  300
gcgaaggag  actatcgtc  acacctagg  ggctaccat  ggaccgcgg  tgactctat  360
agctaccac  gcggcagtg  cttttctgc  cgtgatcga  accccaata  cttgctcat  420
tcctgcgct  tctcctatc  tggggcttg  tggtacagg  actgtcact  cgccaatct  480
aatgggctc  atgggagca  agtggatca  cagggagtg  gctggtacc  ctggaaggg  540
ttcgagttc  cggtgccct  cacggaaat  aagctgaga  ccagaaact  ccaggcccc  600
accaggggc  cctgagcct  ctgcccacc  cactcacac  ctggtatga  tgccgagca  660
tgaggggtt  tgcccagag  agagccagt  tgtctctac  gtgcctagc  caccgagga  720
gccttctct  ccacagtct  acagcacca  gtttacagg  gggagggga  ggaaatgga  780
caataaagg  gaa  793



<210> 8265
<211> 4042
<212> DNA
<213> Homo sapiens
<308> M26856
<400> 8265

tcgacagct  gatttccag  ctggaatcc  gccctccac  acatgcgaa  aatacccgt  60
ttgcatata  agcatggct  tgaagagtt  agtgagtgc  cacaaagca  ttagagcag  120
gtctggtac  tgctattac  ccgcagcgg  aaaccactt  ctcctttgt  ttctgggca  180
ttttgtgag  gaaaggagg  actaataac  atcacactg  gatacctgt  tatactgga  240
tgccccagg  aaaccaggc  taaactgta  tactctatc  gtagcttaa  ctaacaaac  300
acccacaca  atcacattt  gttcttcag  cgattcagg  aggcctatt  ggcagggac  360
gccattttc  ctctgagac  aacatcatg  cagtaaact  gcccacggt  gggtggcag  420
gggagaggg  ccaggtggg  gcggacact  ttgcctgca  aggtgatgt  gaaccagaa  480
gctgactct  gatgcagga  aaaggtcag  gttgcattt  ccttccttg  ttcttgatg  540
gtgatcaat  tttttgaaa  acggacgtc  caaggccaa  gagactggt  tcattccag  600
aaagggcca  tctgtgggc  ggtcggtgg  agggtacct  aaggtgggg  caagggagg  660
cccaaaaca  tctacacag  aggagggat  gctggggct  ttgagctat  agtggcacc  720
cagggccct  acgggcgtc  cgccatgct  ctcctgggc  tgctgctgc  gctgcccct  780
ctggctggc  cccgcctgc  gtggaactg  tggaagctc  ggagcctcc  cctcccgcc  840
cttgccccg  gcttcttgc  cttgctgca  cccgacctc  caatctatc  gcttggcct  900
actcagaaa  tcgggccca  ctacaggct  caccttggg  tgcaaggtg  gaggctgat  960
tcgctctgg  cctcaccat  ggagggggc  gaggtgacg  agagggtcc  ctctccgct  1020
acgctgctt  ggctgtctc  cagatgtgg  ggtgctgaa  tccaagagg  ccattgagg  1080
agccatggt  aaaaagtgg  cagactttg  tggcagacc  gagccactt  cctgtaagg  1140
ctgggggca  tttttcttt  ttaaaaaaa  tttttttta  gagatgggt  cttgctatg  1200
tgcccaggc  ggtcttaaa  tcctagtct  aaatgatcc  cccacctca  cctcaagtg  1260
gagccacct  tggggcatc  ccaatccag  tccctggaa  ctcttgggg  ggcatatct  1320
gtggggaga  agcaggggt  ggggaggcc  aagaaggtc  ggccctcag  tgccttcat  1380
agttcccac  ctccagccc  cacctcctc  tgcagacaa  ctggtgtct  ggaactacc  1440
ggacctgtc  ttgggagac  actccctgc  ctggaaagc  cacaagaag  tcacccgct  1500
agccctgct  ctgggcatc  gtgactcca  ggagccagt  gtggagcag  tgacccagg  1560
gttctgtga  gtaaggctg  gctcctgag  ccacctcgg  tcagccttg  ctctcacag  1620
agcccccgc  ctgcccgct  cacagcggc  tgctgaact  acactgttt  tccacagcg  1680
atgagagcc  agcccggca  ccctgtggc  attgaggag  aattctctc  cctcacctg  1740
agcatcatc  gttacctca  cttcggaga  aagatcaag  tgcctcaca  cccctcagg  1800
ccaccccca  cccctccct  agcctctcc  tgtcctgaa  tgaaagtac  ccctccttt  1860
ctggcagga  gacaactta  tgcctgcct  ttacaaatg  atccaggag  tgttaaaaa  1920
ctggagcca  tggtccatc  aaattgtgg  cgtgattcc  tttctcagg  tgaggacct  1980
gagcctaga  acccctggg  tgtagggga  aggctgggg  ggagggaga  gctccttcc  2040
acagctgca  tctcatgct  cctgccgca  ttcttcccc  atccaggtc  ccggaggct  2100
aagcaggcc  tagagaaga  ggatcacat  gtggagatg  agctgaggc  gcacaaggt  2160
gggactgta  gtggacggc  tcccctcgg  ccacagcca  tgatgctac  ggcctcagc  2220
ttgctatga  gcgggttct  ttgcatacc  cagttatgg  cctgttgcc  ctctgtact  2280
ctctcccca  gccagccgc  cagcccgct  ctttcaccc  ctgcaggag  gcctcgtgg  2340
aggccagtg  agggacatg  tggactaca  gctccaagg  gtggcgcag  cgagcatgg  2400
agagggctc  ggacagctc  tggaagggc  cgtgcacat  gctgcagtg  acctcctga  2460
cggtggcac  gagaccaca  caaacaccc  ctcctgggc  gtggttttt  tgcttcacc  2520
ccctgaggt  cgtcctggg  acaagcaaa  ggctccttc  cagcaacct  gccagggcg  2580
tgggcaccc  cactcagct  tgagcactg  gcggctggg  ctgtgcttg  ctcaccggc  2640
ctcaggctc  ctgggttgc  gagggagcg  ctggaggct  ggcagctgt  ggctgctgg  2700
gcaggactc  acccgatca  tccccagat  cagcagcga  tgcaggagg  gctagacca  2760
gaactgggc  ctggtgcct  cagctcccg  gtcccctac  aggaccgtg  acggctgcc  2820
ttgctcaat  ccaccatcg  cgaggtgct  cgcctgcgg  ccgttgtgc  cttagcctt  2880
ccccaccgc  ccacacggc  cagcaggtg  ctcccgagg  ttggggatg  gtgaggaaa  2940
cccgagccc  gggaggtcc  ggccagcct  taactccag  ccccttcag  atctccggc  3000
acgacatcc  tgagggcac  gtcatcatt  cgaacctcc  aggcgccca  ctggatgag  3060
cggtctggg  gaggccaca  gagttctgg  ctggtatgt  gggggccgg  ggcctgccg  3120
gaaaatgtg  tggaggctg  tccccgctg  cgctgaacg  ctccccacc  acctgtcca  3180
ccgcccgca  atcgcttcc  ggagccagg  aagaactcc  gagctctgg  cttcggctg  3240
ggtgcccgc  tgtgcctgg  cgagccgct  gcgcgcctg  agctcttcg  ggtgctgac  3300
cgactgctg  aggccttca  gctgctgcc  tccggggac  ccctgccct  cctgcagcc  3360
ctgccccac  gcagtgtca  cctcaagat  cagcctttc  aagtgcggc  gcagccccg  3420
gggatgggg  cccacagcc  gggccagaa  cagtgatgg  gcaggaccg  tgccagccg  3480
gtacctcag  ttctccttt  ttgctcctg  acgaacccc  cccctcccc  ctgtaaaca  3540
agtgctgcg  gatcgctgg  agagaaggc  tcctccagc  gctgggtgg  gaaggaccc  3600
ggctcttct  tcggggcga  ccctcagtg  tcggcagtc  tactggggt  cgagagagg  3660
gggcagcag  tcagcctcc  cccgctggg  agcgaaagt  tcttggtct  agcttcatt  3720
ccgtgaagg  caccgagaa  tcgaagccc  tccagtggt  ccagctcac  ccctgggaa  3780
ggggttgtc  agagagagt  aaagccgga  gtcccatct  ctcttcccg  tccccttaa  3840
gaggtagct  ccagcactc  accaacctc  ccgcagagc  cccttcctg  ccctccgct  3900
cagaggatt  aggcttaat  ctgagctgg  cctttccag  caataaatc  actccagct  3960
cctctgcga  gctggcatg  ttgttccat  tcacccagc  actcagtcc  ttgcctgtt  4020
cactgtggg  ctgaaacct  gg  4042



<210> 8266
<211> 3285
<212> DNA
<213> Rattus norvegicus
<308> U24652
<400> 8266

tcctagagc  caaagccca  gctccaaga  gcctgctcc  gcatccagg  ggtccgacc  60
tgcacacgc  tggagatgc  ggacaacct  tacaccttt  tgttgaagg  gcagggcca  120
acagacatc  tctttgagg  gggagatga  cagcagctg  actcatggc  ggcagaact  180
agggcaagc  caggcctag  gttggagca  ctggacaca  agttacctc  ttccttagt  240
gcagagcct  gcccagcta  atccccaag  ggaagcacg  actccctgg  ccaaggtgc  300
tcacctggg  tgatgttgg  cccagcctg  cagaaaaca  atcacttcc  gtcctgcta  360
ccctggttc  acggcccca  ctccagggt  agggctgca  agctggttc  gctgcaggg  420
cctgatgcc  acggtgtgt  cctggtgcg  cagagtgag  cccggagag  ggaatatgt  480
ctcacattc  acttacagg  gagagccaa  cacctccgc  tggtgctca  agagcgtgg  540
cagtgccgg  tgcaacacc  gcacttccc  tcggtggtg  atatgctcc  ccacttcca  600
cgctccccc  tcccacttg  atgtggagc  gcctgtgat  tccgactct  tggctatgt  660
gtagtcgtc  ctcaggcac  agagctggg  catccccac  tcagctctg  tggctgtcc  720
cctggccat  gtgcagagg  tctccgtgg  caagtgaca  ctcctgagc  gatcttcca  780
ctggtgcct  ctcctgagg  actggccaa  agtctgcgg  agctggagc  tgagtctgt  840
agcagtgcc  gggactcag  ctatgaaat  gactcctcc  cacggagcc  ccttcgggc  900
attgacaac  agtacaccc  tctctcaca  ctgtgcaga  aggcaaact  gtgaatgta  960
ccattttcc  tccctccag  gaactacag  ctgctgctg  cagccttcc  cagctcaga  1020
gtgcctgct  ccaccacac  caaggctgt  acaggcttc  gtcagccac  gctagcctg  1080
cttcttccc  ctgtctgta  atgtagttc  tgtgcacag  tgccactag  tggcaccaa  1140
gcctcgttc  caacccaga  gaggcgggg  tgcaggccc  gagctggca  tggaaactg  1200
cagagctga  gacagactt  ttaccaggt  gggtcatcg  gaagcacaa  acactaaca  1260
tccctggat  ctcacatgg  gtccttccc  gtagcttca  tctgtggca  gtctaagtc  1320
catgtcaca  gcgtaggac  cttcataat  ctgcttcta  tcttagctt  ggacagaag  1380
tctgccaga  gggcaagct  aaagatcaa  aatgattta  acattttac  tcagagtaa  1440
tatttttaa  gggttcagg  ttccacttg  tattatagc  tacttcact  cactgccct  1500
ctaccccct  ccactgtaa  gttgggggg  gctgagtcc  cctgctttg  ttaccttga  1560
ccaggctag  atgctagtg  ccttgtctg  tcaccctca  gacagttgc  tgctacggg  1620
tagacactg  cctccctaa  gtagagaat  aagtgtgtc  ccctctcag  gaaatccag  1680
cagcttgca  agagaggag  gtggcaggg  acattccac  ccagtgcct  atgcattaa  1740
aacaaaatc  ggactgtgg  ttacagcag  gttagagga  gagatgaat  ggtggggga  1800
gacaaacac  gatggaagg  ctctaggct  ctttagtga  cccacattt  actcccccc  1860
accccctcc  agcatctag  ggcttagtg  gtttggccc  tgctatgaa  aaactcctg  1920
aaccgctcc  aggtgttct  atccataca  tctttccat  tagacagag  caaaaactg  1980
catctttcc  aagggatgc  gttcacagg  actggagca  gctgttcat  gcacaaaca  2040
tgcttacag  agtggcttt  ggaaaccac  acttaattc  ttgaacatt  agaggcagc  2100
atgctgctg  cctgctgca  acagcagtg  tgactcccc  tctgctcac  ttgcactcg  2160
gaagcctgc  tgggctttg  tgatggaag  agctgcacc  cagcttcga  acccaccac  2220
ggtgtggac  tgtgctcat  ttaggacag  gccttcctt  actgcacat  aggtatgaa  2280
cagagacgt  agcagtaac  gccagtggg  caggccggc  ctaatccac  caggatgcg  2340
ggacggctg  gccctgcac  tggccagga  ctaaaccca  ttcaaactt  gggcactca  2400
ttctcctgg  ccttcaaag  gagacttgc  aggtgctgt  agccagcac  ttggcccct  2460
agtgctggg  ttcactcac  gtggacagc  ttgtttcaa  aaatgtcca  gatatcaga  2520
aacaaggta  aaaagtctc  tgactctgt  acagagtga  aacactaag  cagcacctt  2580
tctttaagc  aaagtaggt  agttggctg  cggggacag  cgggtaccg  gtatgagaa  2640
tcctgggcc  gataccctg  gtcaaagcc  ggccccact  ccaccctca  cagtgtctt  2700
tggccacac  aggcaggat  ggtcagtgg  cactagaga  agagcagct  aacagtcct  2760
aacccctgc  cccttctcc  gagtactca  ctcagacta  caagcacca  caccaaaga  2820
ttaggtcaa  taacctgcc  tgtctttac  agcatccac  tggctttat  tgtataaat  2880
ttctgcctt  gatcatttc  ggatggtgt  ggaaaaaag  aatagtgac  attacagtc  2940
tgggccaga  aacactatt  ttacctaag  ctcttaacc  aaattacgt  gcctcttcc  3000
gaggctcag  ctcttgttt  aatgttacc  tggtgcaaa  aaaagtgat  aactgtccc  3060
cactgcctc  tgacgagac  catctgtct  atggccagc  tgtggctgg  ataagcagc  3120
ttgtgacca  aggatcagg  gacttcatc  tctatcatt  gagcagaag  tatttggca  3180
atctttgtt  tatgtactg  acgagtaac  tattcttga  taatgcaaa  tttcctaca  3240
tgtacaaat  gctgtatgt  aattaaaaa  gttttcaga  ttaca  3285



<210> 8267
<211> 368
<212> PRT
<213> Rattus norvegicus
<308> P50745
<400> 8267

Met Ala Gly Arg Thr Gln Gly Lys His Arg Pro Arg Val Arg Thr Cys 
  1               5                  10                  15
Pro Ser Leu Val Pro Phe Asp Asn Pro Cys Trp Pro Pro Ser His Gln 
             20                  25                  30
Pro Leu Pro Leu Gln Val Gly Ala Pro Gly His Arg Val Thr Ser Phe 
         35                  40                  45
Leu Ser Gly Arg Ala Trp Pro Ser Tyr Ile Pro Lys Gly Lys His Gly 
     50                  55                  60
Leu Pro Gly Pro Arg Tyr Val Pro Asp Pro Trp Ser Leu Gly Val Leu 
 65                  70                  75                  80
Gly His Val Ala Pro Leu Arg Val Thr Thr Thr Ile Phe Leu Pro Gly 
                 85                  90                  95
Ala Ser Pro Gly Val Met Leu Asp Pro Ala Cys Gln Lys Thr Asp His 
             100                105                110
Phe Leu Ser Cys Tyr Pro Trp Phe His Gly Pro Ile Ser Arg Val Arg 
         115                120                125
Ala Ala Gln Leu Val Gln Leu Gln Gly Pro Asp Ala His Gly Val Phe 
     130                135                140
Leu Val Arg Gln Ser Glu Ser Arg Arg Gly Glu Tyr Val Leu Thr Phe 
 145                150                155                160
Asn Leu Gln Gly Arg Ala Lys His Leu Arg Leu Val Leu Thr Glu Arg 
                 165                170                175
Gly Gln Cys Arg Val Gln His Leu His Phe Pro Ser Val Val Asp Met 
             180                185                190
Leu Arg His Phe Gln Arg Ser Pro Ile Pro Leu Glu Cys Gly Ala Ala 
         195                200                205
Cys Asp Val Arg Leu Ser Gly Tyr Val Val Val Val Ser Gln Ala Pro 
     210                215                220
Gly Arg Lys Pro Lys Val Val Ser Arg Gly Gly Val Thr Ala Ser Thr 
 225                230                235                240
Ala Arg Thr Lys Leu Pro Ser Trp Leu Arg Leu Leu His Gly Val Ile 
                 245                250                255
His Val Ile Ser Pro Gly Ser Ser Asn Thr Val Leu Phe Pro Phe Ser 
             260                265                270
Leu Pro His Trp Asp Ser Glu Leu Gly His Pro His Leu Ser Ser Ala 
         275                280                285
Gly Cys Pro Pro Gly His Gly Ala Glu Ala Leu Arg Gly Gln Val Thr 
     290                295                300
Pro Pro Glu Gln Ile Phe His Leu Val Pro Ser Pro Glu Glu Leu Ala 
 305                310                315                320
Asn Ser Leu Arg Gln Leu Glu Leu Glu Ser Val Ser Ser Ala Arg Asp 
                 325                330                335
Ser Asp Tyr Glu Met Asp Ser Ser Ser Arg Ser His Leu Arg Ala Ile 
             340                345                350
Asp Asn Gln Tyr Thr Pro Leu Ser Gln Leu Cys Arg Glu Ala Asn Leu 
         355                360                365



<210> 8268
<211> 5423
<212> DNA
<213> Homo sapiens
<308> NM_005475
<400> 8268

cccgggcca  cgcctccgc  cggctgccc  cccggactg  cgcggcccg  ggtggcgac  60
gcggccgct  caaagtttc  ccggcggcg  cggcccggg  gcgcatcct  ccgcaactg  120
caagcgctg  cggcggaaa  gatgaggcg  tggccattt  ccgagcccg  gtttcctgc  180
tgagccccg  tcgagcgag  cgcgagcga  gagccggcg  gcgggagag  acgcgccca  240
ggcgggggc  cgcccgccc  ctcgggatt  cgagggccc  ggggcgcgc  acgccatgg  300
ccggccggg  ccagagctc  tgtctctca  cccggccgc  ccacctggg  ctccgccat  360
aacgggcct  ccctgcagc  ctcctcgcc  tcttccgcg  cctcagcct  cccggcggc  420
gccccgcgg  gctggagcg  gttctgtga  ttgcacgcc  tagcggcgg  ccgggagct  480
gcccgccag  actggctgt  cgcccggga  catccgcag  acgcgccgc  gcgcgccga  540
ctggtgtcg  tgcagttca  cgacctctt  cagcgctac  tctgccgcg  ggtgcgcga  600
ggacgggcg  cgggccgcg  ctaccggga  acaggccgt  ggcccccag  caaggccga  660
gcgtccccg  agccaggcc  cggccccgc  gcccctggc  tgcccaagg  ccgcagctc  720
gaggagctg  ccccgccgc  gccgcccgg  ccctgctcc  tccagcact  tcgccgcag  780
ctccgccac  tcttccgcc  ccgctcggc  ggggagctg  cagcggccc  caccgctgc  840
gcccccggg  cccccggag  ggctgctga  acccccgcc  ggcctggcc  ggccaagaa  900
ttcctgccc  ggagcctgg  ccgggagcc  ccacccgag  cgctgaagg  ggcggtgct  960
cgctacagc  tggccgacg  ggcctccat  gacagcggg  cacgctggc  gcgcgggag  1020
ctggcgctg  gccgggccc  gggccccga  ggccccgac  gcgtgctgg  gctcttcga  1080
ccacccaag  gttcaaggc  caagctaca  gcagcttgc  ccagcatcc  ggaggtccg  1140
tggtgcaca  ggcttgaga  gcctgacaa  ctttacacc  ttgtgctga  ggtgaagga  1200
cggacagac  tcatctttg  ggtgggaga  gagcagcag  tgaattcat  gatggctga  1260
ctctcggag  gcacaggcc  agggctgga  agcacagaa  cagagatgc  tattccctc  1320
gccctagag  ctagcacgt  cagctcccc  aggggcagc  cagattccc  taaccaagg  1380
gcttctcct  gggggctgc  ggacccggc  tgccagaag  cggaccatt  cctgtcctg  1440
tacccctgg  tccacggcc  catctccag  gtgaaagca  ctcagctgg  tcagctgca  1500
ggccctgat  ctcatggag  gttcctggt  cggcagagc  agacgcggc  tggggaata  1560
gtgctcact  tcaactttc  ggggatagc  aagcacctg  gcctgtcgc  gacagagcg  1620
ggccagtgc  gtgtgcagc  cctccactt  ccctcggtc  tggacatgc  ccaccactt  1680
cagcgctcg  ccatcccac  cgagtgcgg  gccgcctgt  atgtccggc  ctccagcta  1740
gtggtagtc  tctcccaac  accaggttc  tgcaacacg  tcctcttcc  tttctccct  1800
cctcactgg  attcagagt  ccttcctca  tggggttca  agttgggcc  tccccacct  1860
agttcttct  gctgtcccc  ggggctcag  ccagagggt  tcccagggc  atcctcacc  1920
cccgagcag  tcttccacc  ggtgccttc  cccgaagaa  tggccaaca  cctgcagca  1980
ctggagcat  agcctgtga  tcgagcccg  gactcggac  acgaaatgg  ctcatcctc  2040
cggagccac  tgcgggcca  agacaatca  tacacacct  tctgaccag  gaggaattc  2100
aggcctcaa  agctgccct  gaggagcac  ggcagaagt  tgaacttgt  aatgtaatt  2160
atctttcct  ccttccaga  aaagattta  gggacactg  taactgctc  tgccagttt  2220
gaagtgacc  ttctattag  cctgttgaa  ggccctcct  taggtttca  ctatccacc  2280
ggctttctc  ttattgttt  cagatgtag  tcttgttag  ggatgccgc  agctcctgc  2340
cggggtccc  atgcccagt  cccgttact  ttagagaaa  gagttgggg  gagggccag  2400
gctggcagt  gaaacttgt  ctctttttc  ctgacactg  cacagcgga  gacagactt  2460
ctacgggga  gaggggggg  tcatcagga  gcccagaac  ctaacaagc  gttctccca  2520
ctaccgtca  tccacatgg  aggtctgct  tgtccacac  acagatgac  acatctaat  2580
ctgcttcta  tctcagctt  aggacaaaa  ctctgtcag  ggcacaagc  gaaggtcaa  2640
aatgattta  aacatttta  ctcagacta  tttctttaa  ggattcagg  tcaaaactt  2700
accactgct  atttcagtg  actgtttca  ctaacaccc  tgctatttt  gtagtcaga  2760
acagctatg  aaaccctac  taatttaca  tctgagcca  catgctggc  tgtctactg  2820
atcctcggg  cagtcacct  ccactgagt  gccactgtc  ttcctaaat  tcaagaagt  2880
aagtatgtc  ccctttcag  gaaattcag  caattactg  aataggaag  tggcaagaa  2940
agttctatc  tggtgcctt  cgaataaaa  actggattc  ggtttacag  agctttaca  3000
tgatagtta  attaactgg  gctagggga  aagcaacca  aaagggaaa  aggactcct  3060
ggccctttc  attaaatcc  tcagcaaca  ggctggctt  gtgccctcc  agcatctaa  3120
ggcttatta  attatccca  aattgggtt  taggctcct  ttttgaccc  aaatggaag  3180
tgggaatct  gtgccataa  taatgagaa  ctcctttaa  accccacaa  cagtgttct  3240
ttctacctg  ctactgctt  actggattg  aaatctatc  atctccttg  acacatggg  3300
acacacaat  tccaccatc  agggaggtc  tgaattcaa  tctctatct  tccaagtga  3360
acaattcat  gggggctgg  tcctcccag  acctgtctg  aggctcaga  acgggggca  3420
tgacagtgg  gtcagctgc  cttgggtgc  agcagagcc  ttcagtaca  cccccaggc  3480
cacagcagt  gcttctagg  aactgggag  ttagatcag  tttacagat  catcgatca  3540
aggctaaaa  gaaacctca  cctaaaact  ataggactg  ctgcctggg  ggagggtta  3600
gtctgcttc  tccacttat  cttagtctc  gtgctccaa  aggtcaaat  tttgcttct  3660
gaatttcct  ggggtcttt  agagggtgg  ggaacaaac  cctatgcac  tttcttttt  3720
ttttttgag  tggagtttc  cttgtcaac  gggctggag  gcagtggtg  aatcttggc  3780
cactgcaac  tccaccttc  tggttcaag  gattctgcc  cgacctctc  agtagctgg  3840
attacaagc  ccagccacc  tgcctggct  attttgtat  tttagtaga  acagggttt  3900
accatgttg  ccaggctgg  ctcgaatgt  tgacctcag  tgatccacc  gccttggcc  3960
cccaaagtg  tgggattac  ggcgcgagc  accgcgccc  gcctacacc  cttttagta  4020
caacactct  gggtgattt  atggaccct  aagcagacc  gacactgat  cagatttgc  4080
gtccatttt  aaggacacc  gtctttatt  cctcaaagt  aagcagctt  ctctggaaa  4140
tgaatgcta  ttagtgtga  ccaaaagag  aagtaagag  ctgaagttt  tttaaagga  4200
aaagcttat  atggaaagt  actggtcct  ccctccgca  aggaaaggt  cccagtaga  4260
aatgaacca  attaagttc  ctccctcca  ccagaagtt  aacatctgg  atatgacgt  4320
ttcatgcca  gggcactca  ttcttagca  cctctctac  tacatctct  aggtggtgc  4380
aagaggcac  ccaggtaga  caaacttag  agctctgac  aacaggctg  aaagtgcaa  4440
ttcagattc  gtggcagag  tttggaggg  acccacgtc  agactgctt  ccgtccaag  4500
taccaggac  gctcaaaaa  atgctgaca  aaaactccc  tggctctag  aaaaagtga  4560
actaagcca  cacctttct  tatgtggga  caaaatcag  tgatgaagg  gtgggcacc  4620
ttgtggggc  ggcacccca  tggctgcag  tagcccacc  taggcacag  acatcccac  4680
actctcctt  cagtcctga  caggcccca  ccggcaact  ctaccgaga  ccatggctc  4740
acaccaaac  ggacagtag  catcatgat  cctccagtt  gctctaatt  cagacccca  4800
cagtacagc  tgacagctc  cggcaccat  ccttccttc  tctgactta  tgaactttt  4860
caaactaac  gtcaccagc  ccaaagaat  aagtcaact  acctgcctt  aattttaaa  4920
cagcaatcc  tatggcttt  tctggtata  atcttctgc  tttgatcat  tctggaccg  4980
aggaaaaag  aatagcaat  attaaaatc  tgggccaga  aacactatt  ttacataac  5040
gtttcttaa  ctaaagtca  ggccttgga  tcttccctg  gggttgcct  aaattcctt  5100
atgctttct  ttcaggact  attccctta  tgcaaatgt  ttagctcta  catctccca  5160
aagctaaag  aacttgcaa  tatattaac  aggacacat  tgacatcct  tgtttggtt  5220
aaatataca  cacattgtg  taacataaa  tggatccat  ttgtatcat  ataggcaaa  5280
ggtatttgg  aaattttta  gtatggttt  atgtactgt  caagtaact  attcttgaa  5340
aatgcaaat  ttgctataa  gtacaaatt  ctatatgtg  attaaaaag  ttccaaaat  5400
ttgaaaaaa  aaaaaaaaa  aaa  5423



<210> 8269
<211> 575
<212> PRT
<213> Homo sapiens
<308> Q9UQQ2
<400> 8269

Met Asn Gly Pro Ala Leu Gln Pro Ser Ser Pro Ser Ser Ala Pro Ser 
  1               5                  10                  15
Ala Ser Pro Ala Ala Ala Pro Arg Gly Trp Ser Glu Phe Cys Glu Leu 
             20                  25                  30
His Ala Val Ala Ala Ala Arg Glu Leu Ala Arg Gln Tyr Trp Leu Phe 
         35                  40                  45
Ala Arg Glu His Pro Gln His Ala Pro Leu Arg Ala Glu Leu Val Ser 
     50                  55                  60
Leu Gln Phe Thr Asp Leu Phe Gln Arg Tyr Phe Cys Arg Glu Val Arg 
 65                  70                  75                  80
Asp Gly Arg Ala Pro Gly Arg Asp Tyr Arg Asp Thr Gly Arg Gly Pro 
                 85                  90                  95
Pro Ala Lys Ala Glu Ala Ser Pro Glu Pro Gly Pro Gly Pro Ala Ala 
             100                105                110
Pro Gly Leu Pro Lys Ala Arg Ser Ser Glu Glu Leu Ala Pro Pro Arg 
         115                120                125
Pro Pro Gly Pro Cys Ser Phe Gln His Phe Arg Arg Ser Leu Arg His 
     130                135                140
Ile Phe Arg Arg Arg Ser Ala Gly Glu Leu Pro Ala Ala His Thr Ala 
 145                150                155                160
Ala Ala Pro Gly Thr Pro Gly Glu Ala Ala Glu Thr Pro Ala Arg Pro 
                 165                170                175
Gly Leu Ala Lys Lys Phe Leu Pro Trp Ser Leu Ala Arg Glu Pro Pro 
             180                185                190
Pro Glu Ala Leu Lys Glu Ala Val Leu Arg Tyr Ser Leu Ala Asp Glu 
         195                200                205
Ala Ser Met Asp Ser Gly Ala Arg Trp Gln Arg Gly Arg Leu Ala Leu 
     210                215                220
Arg Arg Ala Pro Gly Pro Asp Gly Pro Asp Arg Val Leu Glu Leu Phe 
 225                230                235                240
Asp Pro Pro Lys Ser Ser Arg Pro Lys Leu Gln Ala Ala Cys Ser Ser 
                 245                250                255
Ile Gln Glu Val Arg Trp Cys Thr Arg Leu Glu Met Pro Asp Asn Leu 
             260                265                270
Tyr Thr Phe Val Leu Lys Val Lys Asp Arg Thr Asp Ile Ile Phe Glu 
         275                280                285
Val Gly Asp Glu Gln Gln Leu Asn Ser Trp Met Ala Glu Leu Ser Glu 
     290                295                300
Cys Thr Gly Arg Gly Leu Glu Ser Thr Glu Ala Glu Met His Ile Pro 
 305                310                315                320
Ser Ala Leu Glu Pro Ser Thr Ser Ser Ser Pro Arg Gly Ser Thr Asp 
                 325                330                335
Ser Leu Asn Gln Gly Ala Ser Pro Gly Gly Leu Leu Asp Pro Ala Cys 
             340                345                350
Gln Lys Thr Asp His Phe Leu Ser Cys Tyr Pro Trp Phe His Gly Pro 
         355                360                365
Ile Ser Arg Val Lys Ala Ala Gln Leu Val Gln Leu Gln Gly Pro Asp 
     370                375                380
Ala His Gly Val Phe Leu Val Arg Gln Ser Glu Thr Arg Arg Gly Glu 
 385                390                395                400
Tyr Val Leu Thr Phe Asn Phe Gln Gly Ile Ala Lys His Leu Arg Leu 
                 405                410                415
Ser Leu Thr Glu Arg Gly Gln Cys Arg Val Gln His Leu His Phe Pro 
             420                425                430
Ser Val Val Asp Met Leu His His Phe Gln Arg Ser Pro Ile Pro Leu 
         435                440                445
Glu Cys Gly Ala Ala Cys Asp Val Arg Leu Ser Ser Tyr Val Val Val 
     450                455                460
Val Ser Gln Pro Pro Gly Ser Cys Asn Thr Val Leu Phe Pro Phe Ser 
 465                470                475                480
Leu Pro His Trp Asp Ser Glu Ser Leu Pro His Trp Gly Ser Glu Leu 
                 485                490                495
Gly Leu Pro His Leu Ser Ser Ser Gly Cys Pro Arg Gly Leu Ser Pro 
             500                505                510
Glu Gly Leu Pro Gly Arg Ser Ser Pro Pro Glu Gln Ile Phe His Leu 
         515                520                525
Val Pro Ser Pro Glu Glu Leu Ala Asn Ser Leu Gln His Leu Glu His 
     530                535                540
Glu Pro Val Asn Arg Ala Arg Asp Ser Asp Tyr Glu Met Asp Ser Ser 
 545                550                555                560
Ser Arg Ser His Leu Arg Ala Ile Asp Asn Gln Tyr Thr Pro Leu 
                 565                570                575



<210> 8270
<211> 4359
<212> DNA
<213> Rattus norvegicus
<308> U25281
<400> 8270

gccaggcgc  cagaagcaa  gccaggcac  gccggcaga  caactggga  cctcgaggc  60
gcaagagga  agggacagc  gggaccgcg  ctccagtaa  agtccagtc  gcccggtta  120
ggccagctg  agaccagaa  ctactctct  ggagccatt  gtaagcaag  gacgccaac  180
ctgtgtgac  tatgccggt  ccaccacca  cacccccac  tcttcctcc  ccccctcca  240
ctctgggag  tcctccccc  ccaccccca  cagggcccc  gatcagcac  gacgctccc  300
gcttaagga  gtcagatct  aaaggtcgg  gtgcactgt  ggctgatat  cagcaagga  360
cacgcctgc  aaaagtcac  cagatcaat  accgcagtg  cccacaaat  gagagttca  420
aaggaacca  caaagaggg  ggagctgct  gcagcaatg  ccgtggagg  agcacgccc  480
ctgccctgg  agatctctt  gctggtggc  ttcctgtgt  gaggccagc  ggccagcgg  540
atgtggcag  tggcaagac  ggacagggc  ctggctccc  agcgccttc  ccccggctc  600
ccaccaaag  catcagcgg  ccccttccc  ctcctgcat  ccccaggct  ggcaatgcc  660
cagatacac  cagctctgc  aggccagtc  ctcctcgcc  cagtgtacc  gccccaccg  720
ctcccacta  acccccacc  ccgcctcca  ctccacctc  acctccacc  ccacccctc  780
ccccagcct  ccccatcaa  gccccatcg  tgtccccac  tgtccctcc  accaagggg  840
atccgtctg  ggtgccagc  cctataccc  gcgtacctc  ccttccgcc  cctcccccg  900
ctccgcccc  tctgccccc  gcctcagca  tcagtgaga  ggcagtgag  ccccaacta  960
ccccgctgc  cctgccacc  ataccacct  cgcttcctc  cctgccacc  tatgggtac  1020
cggcgctcc  ctcagagcc  agcagccct  cccaggacg  gagagagcc  ccagctcct  1080
ctccaccac  gccaccacc  ccaccacct  caccaccac  gctccccac  tacgcctct  1140
gctctccaa  ggccgctgt  gccccgccc  cgccccctt  gccaggctc  agcaacagc  1200
gcagcgaga  tcctccccc  ctgcccccc  agtccccca  cttccagac  cagaaagcc  1260
tgcccacac  tccaggtgc  cccggccct  agatcatcc  gcagaagaa  cgtcgaggc  1320
caggagccg  tgggggaaa  ctaaaccca  ctccagccc  acctgcaag  tcgcccacc  1380
ctgagctct  cagcaaaac  cagcagcct  gaggacagc  gcggaatgg  ggccagcac  1440
tgattggcc  cacacctgg  tcctggctc  aagctgagg  agctgggca  agctctgat  1500
acatcaaaa  cagaaattc  cagttatct  taaaggcac  ccggtgaga  gatggtgac  1560
tcaaggtcc  ggggttctg  actagacac  aggacaact  cttgagact  tactgtact  1620
aagatctac  cctttgaat  caggcaccg  actgagcat  tattttttt  gtaaataat  1680
atttgcatg  agcccttag  caccatgtt  gtcaacttt  atttgagta  cattttaat  1740
tttttaaaa  aagcaccct  acatttgtc  gtcttgtac  gatggctcc  gatcccgcc  1800
tgtggtgtc  actgtgact  gaacatatg  ttgcaggct  gtccttcga  gattctgaa  1860
ccttttcca  agcatcctt  gttttcgag  agtccaaaa  tcataacta  ccacaacag  1920
ttcttattg  catgactct  atcactcca  ccgcaaaat  aaaccaaat  atgccttat  1980
aaccacgca  ctcagagga  gcagtgtgt  gccaggtcc  ggtgttgcc  ctcagcttc  2040
agtgagcga  aagccatgt  tcgcttcct  ttagcagta  agggacgtc  ttttgctgc  2100
taatgtgtg  atatatata  atatttata  cccaaggta  aggctagag  gggcgtggc  2160
cctcccatg  cttccgcag  gcccctttt  taactgaat  cttttacag  tagccaatg  2220
tcttactgt  tacagcatc  ccagcgcca  tctttaccg  tttccttca  cacctccaa  2280
ttcccagct  catgctggt  gccagggta  agtcagctt  atgagattt  gatatcctc  2340
catccctgt  gactacggt  gtatatagc  catgattat  aataagttt  tttttacct  2400
agaagtctc  ctccccaaa  tctactcag  gtgtaagat  tacatggaa  atacaacat  2460
tatttaaaa  gaacaagaa  aaaaggagg  tggagaaat  gacccactg  taacatgcc  2520
gctaaggac  tacacacag  gctggatgt  gtaacacac  cttgttatt  cattactgg  2580
ggagcagag  caggcagat  cctgtgact  actggccag  caagctatt  aaggagcct  2640
aggttccag  aagtggcat  gtctcaaaa  acaaggtgg  aactcctga  gccacaaca  2700
ccaaagttg  cctctggcc  cttacaggt  cacgcatga  atgtgtgca  acatcccac  2760
cagggacat  cacactcat  cagaaacac  tagcaaaga  cagagcagc  cttggagca  2820
atctcaaat  tcctgcccc  ttggtagga  tctcagaat  cccatcagc  caaaggacc  2880
tctctctga  cttcatctg  gagcgcaga  ggctctgtt  cctggtggc  tgtgcctgg  2940
atgcccagc  gtaataggc  gcgagttca  ctgtcctga  tagacagag  gccacgcag  3000
ctggggctg  tctctgcac  cttctttga  tctcaaggg  gaaaagtat  cttttgctt  3060
ttgtcaggc  ccaaatgct  ccatccact  gagagggga  gctgtagca  aggaggggg  3120
aatgggagg  aacagtccg  tccctcact  tattcagaa  agctgcaga  agaagagag  3180
ggaaatgaa  caatggtgt  gctttggag  actccgacc  caagaacat  agcccaggc  3240
gggccatca  gggccaatg  attaggaga  tgttcagct  tgtgtctgc  cacacctga  3300
tattgtttg  agcaaatgt  ctgcattag  gtcatgctt  ctcctgcca  ataggagaa  3360
ctgagccag  gtcaagttt  caaaatctc  ggggcagtg  ctcaaggcc  tagttacag  3420
cacatcagc  gacatgacg  ttctacgtt  ctggtttgt  acggtggct  tggaagtgt  3480
cagaaaggt  agaagccac  ctactcttc  cctagccat  cagagtaat  atcattaaa  3540
agctttcat  actacgatg  gggccatca  gaaggcagt  ctgcctttg  aatcagtga  3600
ttgttcaca  acggtgtat  ttcaccatg  attcacatg  tgatgttct  tactgctgg  3660
acaggaatt  aaactattc  agagtgggg  agatgtctc  gtctgtaga  atcctgctg  3720
ccaagcatg  ggaccggaa  tcatatccc  aggacctat  taaaagtca  gcatggggg  3780
agcatgtct  taatcctag  agttgggta  aggcatctg  cccaggaag  tcggtggcc  3840
gccaaccta  caaaatttg  aagttgcaa  ctgcaggtt  agtgagaat  agatagaga  3900
agaccaaaa  agatacctg  agatggcct  tgggcttca  atgcatgtg  acacatgtg  3960
cttgttcat  tgcacacac  cacacacac  cacacacac  cgtatatat  atacataaa  4020
attttttac  aacttattt  agggcataa  gaaggaaca  gcagaaacc  aaaaatagc  4080
agcaaggag  attctcagg  atctggcct  gcagctctc  tcaagacct  tcacggagc  4140
taccacctc  aagttcaag  gggtacgtt  ggttcccac  agcagtgta  aggttaggc  4200
tttgactgt  aactcacgc  tggagttgt  cctgctatc  ttgcccacc  ccacattgc  4260
gactgtgac  ctgccccat  tctctgcct  tattttata  ttattggtg  ctcctgctg  4320
agattcatt  ctttgtacc  aataaactt  aataagtga  4359



<210> 8271
<211> 451
<212> PRT
<213> Rattus norvegicus
<308> AAA87791
<400> 8271

Met Pro Val Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro 
  1               5                  10                  15
Pro Leu Gly Ala Pro Pro Pro Pro Pro Pro Pro Gly Pro Pro Ile Ser 
             20                  25                  30
Thr Asp Ala Pro Ser Leu Arg Lys Ser Asp Leu Lys Gly Arg Ser Ala 
         35                  40                  45
Leu Leu Ala Asp Ile Gln Gln Gly Thr Arg Leu Arg Lys Val Thr Gln 
     50                  55                  60
Ile Asn Asp Arg Ser Ala Pro Gln Ile Glu Ser Ser Lys Gly Thr Ser 
 65                  70                  75                  80
Lys Glu Gly Gly Ala Ala Gly Ser Asn Ala Arg Gly Gly Ser Thr Pro 
                 85                  90                  95
Pro Ala Leu Gly Asp Leu Phe Ala Gly Gly Phe Pro Val Leu Arg Pro 
             100                105                110
Ala Gly Gln Arg Asp Val Ala Gly Gly Lys Thr Gly Gln Gly Pro Gly 
         115                120                125
Ser Arg Ala Pro Ser Pro Arg Leu Pro Thr Lys Ala Ile Ser Gly Pro 
     130                135                140
Leu Pro Ala Pro Ala Ser Pro Arg Leu Gly Asn Ala Ser Asp Thr His 
 145                150                155                160
Ser Ser Ala Arg Pro Val Pro Pro Arg Pro Ser Val Pro Ala Pro Pro 
                 165                170                175
Pro Pro Thr Thr Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
             180                185                190
Pro Pro Pro Leu Pro Pro Ala Ser Pro Ile Lys Ala Pro Ser Val Ser 
         195                200                205
Pro Pro Val Pro Pro Thr Lys Gly Asn Pro Ser Ala Val Pro Ala Pro 
     210                215                220
Ile Pro Cys Val Pro Pro Leu Pro Pro Pro Pro Pro Thr Pro Pro Pro 
 225                230                235                240
Leu Pro Pro Ala Ser Ala Leu Ser Glu Lys Ala Val Arg Pro Gln Leu 
                 245                250                255
Ala Pro Leu His Leu Pro Pro Ile Pro Pro Pro Leu Pro Leu Leu Pro 
             260                265                270
Pro Tyr Gly Tyr Pro Ala Leu His Ser Glu Pro Ser Ser Pro Ala Gln 
         275                280                285
Asp Val Arg Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro 
     290                295                300
Pro Pro Pro Pro Pro Pro Leu Pro Thr Tyr Ala Ser Cys Ser Pro Arg 
 305                310                315                320
Ala Ala Val Ala Pro Pro Pro Pro Pro Leu Pro Gly Ser Ser Asn Ser 
                 325                330                335
Gly Ser Glu Thr Pro Pro Pro Leu Pro Pro Lys Ser Pro Ser Phe Gln 
             340                345                350
Thr Gln Lys Ala Leu Pro Thr Pro Pro Gly Ala Pro Gly Pro Gln Ile 
         355                360                365
Ile Leu Gln Lys Lys Arg Arg Gly Pro Gly Ala Gly Gly Gly Lys Leu 
     370                375                380
Asn Pro Pro Pro Ala Pro Pro Ala Arg Ser Pro Thr Thr Glu Leu Ser 
 385                390                395                400
Ser Lys Thr Gln Gln Pro Gly Gly Gln Leu Arg Asn Gly Gly Gln His 
                 405                410                415
Val Ile Gly Arg Thr Pro Gly Ser Trp Leu Gln Ala Glu Ala Ala Gly 
             420                425                430
Gln Ser Ser Asp Asp Ile Lys Thr Arg Asn Ser Gln Leu Ser Leu Lys 
         435                440                445
Ala Leu Arg 
     450



<210> 8272
<211> 340
<212> DNA
<213> Homo sapiens
<308> AA972141
<400> 8272

ttttttttt  aattaaaat  ctgctttaa  gcccgtgca  atcacatat  tacaataaa  60
aaattctca  ttccaagcc  gtatgccaa  tgaattaca  cttgagcat  gggtgggtg  120
ggtctgaca  gttgttctg  aacctggaa  cccaggacc  tcgcttcat  tgccttctc  180
ccgaagagt  tttagagat  actgagaat  tctgccttt  atgtcatca  agctctgcc  240
gactgcttc  gcttggagc  agggaccag  tgtacggct  ctggggatc  tgctggggt  300
aatcttctg  catggttta  attcatccg  agggggaaag  340



<210> 8273
<211> 3531
<212> DNA
<213> Rattus norvegicus
<308> U25746
<400> 8273

cacgctctg  tggcggtca  tgctggagc  ttggccatt  cgtagggcc  gtcctcgct  60
ggtactgtg  ggacttggt  cctccctcc  ttgtcctct  caccggtct  cgcatcgtc  120
ccaagggcg  aggccttcc  ctggctggc  gcatgggca  ggagtctcg  cattaccga  180
aacggtcag  atctcgagg  cgctctgga  gtcggtcta  gagtcgctc  ccctctgac  240
aaagaagca  acgtggaga  gacaggcgt  ccaggagta  agacagaga  agaaggaga  300
agaggtctc  gagcaggga  aaaaggaga  ctcggtcac  ggacaggaa  cgcctgaga  360
gttccagaa  tagagagcg  gacagaagc  gagagcgaa  aagatctcg  agccgggat  420
gaaggcgct  aaggagtcg  agccggggc  ggcggtccc  gtcttccag  cctggcagc  480
aaagcaaga  ggctgagaa  aggtctagg  ccaaagaga  agcagaagg  ggggacagc  540
ccaaggaga  gaagaaaga  aaggacgac  aggaggacg  gaaagagaa  gatgctggg  600
attttgacc  gaataagct  gaagaagaa  tgagaaaac  aaaagaaag  gttgaaaaa  660
ggcgagaag  gcagcgtaa  aaggcgatg  agaacatag  ggagctgaa  aaggagatc  720
aggagatga  gcaggggaa  aagtggagc  tggaagatg  cgacgatga  gaagatgac  780
ctgccgagg  tgagaagga  gggaatgaa  tggaggacg  ggagctgga  ccattagat  840
cctacatgg  ggaagtgaa  gaagaggta  aaaagttta  catgaggag  gtgaaaggc  900
gcgcaggaa  tgagaagaa  tccggaccg  ctgtcacga  agtggttac  gtggtaaca  960
ccaagaaag  agtagtaga  gccgacaag  agaagggag  gctgatgga  aatgaccag  1020
acgccatgg  gtactcctc  gaggaggaa  aggttgacc  tcagacggc  ctcacaggc  1080
accagacaa  acagagaaa  cttctagag  cagtggatc  tgggaaaat  gagtatgag  1140
cattcagaa  aaactttta  gttgaagtt  cagaattag  gaaaatgtc  caagaagag  1200
tgaatgtgt  tcggttgga  atggagggc  ttacagtta  aggaaaagg  tgccccaag  1260
caattaaat  atgggtcca  tgtggaatt  ccatgaaga  actgaattc  ctcaaaaag  1320
atggctatg  aaagcccac  ccaatccaa  ctcaagcaa  tcctgctat  atgtctgga  1380
gagatttga  tggcattgc  aagacagga  gtggaaaaa  cattgcttt  cttttgccc  1440
tgtttagac  catcatgga  cagaggtca  tggaagaag  agagggacc  atcgctgtc  1500
tcatgactc  aactcgaga  ctggcttta  aaatcacta  agaatgtaa  aagttttcg  1560
agaccttgg  actgagagt  gtctgtgtg  atggaggga  aggaatcag  gagcagatt  1620
ctgagctga  gagaggcgc  gagatcatt  tttgcacac  tggccggat  atcgacatg  1680
tggcagcta  cagtggtcg  gtcacaaat  ttcgaagag  gacatatgt  gttttagat  1740
aagcagaca  aatgtttga  atgggtttt  aaccacagg  catgcgcat  gtggacaat  1800
tccgtcctg  ccgacagac  gttatgttc  cagctactt  cccaagagc  atggaagcg  1860
tggcccgca  gatcttgag  aagcccatt  aagttcagg  tggaggccg  agtgtggtt  1920
gctcagatg  ggaacaaca  gtgattgtg  ttgaagaag  gaagaaatt  ttgaaattg  1980
tggagcttt  aggccatta  caggagtca  gatctgtca  tatatttgt  gataagcag  2040
aacacgctg  tggtcttct  aaggacttg  tgagagctt  ctacccttg  atgtctctt  2100
acggaggta  tgatcagta  gacagggac  gtatcataa  tgactttaa  aatggaacc  2160
gcaaacttc  cgtagccac  tctgttgcc  cccgtggtc  agatgtgaa  catctcatt  2220
ttgtagtaa  ttacagctg  cccaatcat  acgaagatt  cgtgcacag  gctgggcgg  2280
ctggaagag  aggcaacaa  ggttatgcc  acaccttca  cacagaaga  caagctcga  2340
atgctgggg  catcattaa  gctcttgaa  tgtcgggga  ggcggtgcc  cctgaccta  2400
agaaactat  gagtgactt  aaagatcag  agaaagctg  aggaaaaat  attaaaaag  2460
gcagcggct  ctctggcaa  gggttcaag  ttgatgaga  agagcaggc  ttagccaat  2520
agaggaaaa  gctacaaaa  gctgccctt  gcctgcagg  ttctgatga  gaggacgcc  2580
cagttgata  tgacgagca  attgaaagc  tgtttaatt  caagaagag  gtgaaagac  2640
tggctgctc  cggcacatc  agtgcgcct  ctccgactg  gggcaatgc  gagaagcta  2700
agattgcca  gaggttggc  cttagaatc  acgctcaga  gaacctggg  atcgagtct  2760
aggtagatg  gatgcagca  gccacaaat  ccatcctca  aggtggccc  cttctggct  2820
ccaccgtgt  tgcaaaaac  atcgcagag  agcttgccg  gaagatcaa  gccaagctc  2880
attacgtgc  tttggagaa  caggaagaa  agagacagg  gggtgggca  agcgaatct  2940
tcaagagat  cgaggaaga  ttagaaatt  atgacttcc  acagacggc  aggtggaaa  3000
ttacctcta  ggaagcctt  cagaggatc  gtgagtact  ggaagccgc  atcacaatc  3060
gagggacct  cttcccgcc  ggcaaagag  ccaaggaag  agagcggaa  atctacttg  3120
cgattgaaa  tgccaacga  ctggctgtg  agaaagcaa  ggcagagat  accaggctc  3180
taaaagagg  gctgatccg  ctgcaaaat  cataccaac  caccaacaa  ggacgatac  3240
aagtattat  aacaccgga  ccactttgt  cccgtgcta  ctgtgacgt  tacagtgta  3300
tgtaaagta  gacttttaa  attctgtct  gcttatttt  taagtacaa  aaaccagtg  3360
ttgttcaag  ggtcatctg  aagtactac  ctataccca  ccaaactcc  tttaaatca  3420
agctgtttt  agagtgtga  gttcttcga  gtaaacctt  gataccaac  ctttaaata  3480
ctggagaca  tgggatttt  tactgaatg  agtaataaa  tgtgtcagg  a  3531



<210> 8274
<211> 1033
<212> PRT
<213> Rattus norvegicus
<308> U25746
<400> 8274

Met Gly Arg Glu Ser Arg His Tyr Arg Lys Arg Ser Ala Ser Arg Gly 
  1               5                  10                  15
Arg Ser Gly Ser Arg Ser Arg Ser Arg Ser Pro Ser Asp Lys Arg Ser 
             20                  25                  30
Lys Arg Gly Asp Asp Arg Arg Ser Arg Ser Arg Asp Arg Asp Arg Arg 
         35                  40                  45
Arg Glu Arg Ser Arg Ser Arg Asp Lys Arg Arg Ser Arg Ser Arg Asp 
     50                  55                  60
Arg Lys Arg Leu Arg Arg Ser Arg Ser Arg Glu Arg Asp Arg Ser Arg 
 65                  70                  75                  80
Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser Arg 
                 85                  90                  95
Ser Arg Gly Arg Arg Ser Arg Ser Ser Ser Pro Gly Ser Lys Ser Lys 
             100                105                110
Lys Ala Glu Asn Arg Ser Arg Ser Lys Glu Lys Ala Glu Gly Gly Asp 
         115                120                125
Ser Ser Lys Glu Lys Lys Lys Asp Lys Asp Asp Lys Glu Asp Glu Lys 
     130                135                140
Glu Lys Asp Ala Gly Asn Phe Asp Gln Asn Lys Leu Glu Glu Glu Met 
 145                150                155                160
Arg Lys Arg Lys Glu Arg Val Glu Lys Trp Arg Glu Glu Gln Arg Lys 
                 165                170                175
Lys Ala Met Glu Asn Ile Gly Glu Leu Lys Lys Glu Ile Glu Glu Met 
             180                185                190
Lys Gln Gly Lys Lys Trp Ser Leu Glu Asp Asp Asp Asp Asp Glu Asp 
         195                200                205
Asp Pro Ala Glu Ala Glu Lys Glu Gly Asn Glu Met Glu Asp Glu Glu 
     210                215                220
Leu Asp Pro Leu Asp Ala Tyr Met Glu Glu Val Lys Glu Glu Val Lys 
 225                230                235                240
Lys Phe Asn Met Arg Ser Val Lys Gly Gly Ala Gly Asn Glu Lys Lys 
                 245                250                255
Ser Gly Pro Thr Val Thr Lys Val Val Thr Val Val Thr Thr Lys Lys 
             260                265                270
Ala Val Val Asp Ala Asp Lys Lys Lys Gly Glu Leu Met Glu Asn Asp 
         275                280                285
Gln Asp Ala Met Glu Tyr Ser Ser Glu Glu Glu Glu Val Asp Leu Gln 
     290                295                300
Thr Ala Leu Thr Gly Tyr Gln Thr Lys Gln Arg Lys Leu Leu Glu Pro 
 305                310                315                320
Val Asp His Gly Lys Ile Glu Tyr Glu Pro Phe Arg Lys Asn Phe Tyr 
                 325                330                335
Val Glu Val Pro Glu Leu Ala Lys Met Ser Gln Glu Glu Val Asn Val 
             340                345                350
Phe Arg Leu Glu Met Glu Gly Ile Thr Val Lys Gly Lys Gly Cys Pro 
         355                360                365
Lys Pro Ile Lys Ser Trp Val Gln Cys Gly Ile Ser Met Lys Ile Leu 
     370                375                380
Asn Ser Leu Lys Lys His Gly Tyr Glu Lys Pro Thr Pro Ile Gln Thr 
 385                390                395                400
Gln Ala Ile Pro Ala Ile Met Ser Gly Arg Asp Leu Ile Gly Ile Ala 
                 405                410                415
Lys Thr Gly Ser Gly Lys Thr Ile Ala Phe Leu Leu Pro Met Phe Arg 
             420                425                430
His Ile Met Asp Gln Arg Ser Leu Glu Glu Gly Glu Gly Pro Ile Ala 
         435                440                445
Val Ile Met Thr Pro Thr Arg Glu Leu Ala Leu Gln Ile Thr Lys Glu 
     450                455                460
Cys Lys Lys Phe Ser Lys Thr Leu Gly Leu Arg Val Val Cys Val Tyr 
 465                470                475                480
Gly Gly Thr Gly Ile Ser Glu Gln Ile Ala Glu Leu Lys Arg Gly Ala 
                 485                490                495
Glu Ile Ile Val Cys Thr Pro Gly Arg Met Ile Asp Met Leu Ala Ala 
             500                505                510
Asn Ser Gly Arg Val Thr Asn Leu Arg Arg Val Thr Tyr Val Val Leu 
         515                520                525
Asp Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Pro Gln Val Met 
     530                535                540
Arg Ile Val Asp Asn Val Arg Pro Asp Arg Gln Thr Val Met Phe Ser 
 545                550                555                560
Ala Thr Phe Pro Arg Ala Met Glu Ala Leu Ala Arg Arg Ile Leu Ser 
                 565                570                575
Lys Pro Ile Glu Val Gln Val Gly Gly Arg Ser Val Val Cys Ser Asp 
             580                585                590
Val Glu Gln Gln Val Ile Val Ile Glu Glu Glu Lys Lys Phe Leu Lys 
         595                600                605
Leu Leu Glu Leu Leu Gly His Tyr Gln Glu Ser Gly Ser Val Ile Ile 
     610                615                620
Phe Val Asp Lys Gln Glu His Ala Asp Gly Leu Leu Lys Asp Leu Met 
 625                630                635                640
Arg Ala Ser Tyr Pro Cys Met Ser Leu His Gly Gly Ile Asp Gln Tyr 
                 645                650                655
Asp Arg Asp Ser Ile Ile Asn Asp Phe Lys Asn Gly Thr Cys Lys Leu 
             660                665                670
Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Val Lys His Leu 
         675                680                685
Ile Leu Val Val Asn Tyr Ser Cys Pro Asn His Tyr Glu Asp Tyr Val 
     690                695                700
His Arg Ala Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Tyr Ala Tyr 
 705                710                715                720
Thr Phe Ile Thr Glu Asp Gln Ala Arg Tyr Ala Gly Asp Ile Ile Lys 
                 725                730                735
Ala Leu Glu Leu Ser Gly Thr Ala Val Pro Pro Asp Leu Glu Lys Leu 
             740                745                750
Trp Ser Asp Phe Lys Asp Gln Gln Lys Ala Glu Gly Lys Ile Ile Lys 
         755                760                765
Lys Ser Ser Gly Phe Ser Gly Lys Gly Phe Lys Phe Asp Glu Thr Glu 
     770                775                780
Gln Ala Leu Ala Asn Glu Arg Lys Lys Leu Gln Lys Ala Ala Leu Gly 
 785                790                795                800
Leu Gln Asp Ser Asp Asp Glu Asp Ala Ala Val Asp Ile Asp Glu Gln 
                 805                810                815
Ile Glu Ser Met Phe Asn Ser Lys Lys Arg Val Lys Asp Met Ala Ala 
             820                825                830
Pro Gly Thr Ser Ser Ala Pro Ala Pro Thr Ala Gly Asn Ala Glu Lys 
         835                840                845
Leu Glu Ile Ala Lys Arg Leu Ala Leu Arg Ile Asn Ala Gln Lys Asn 
     850                855                860
Leu Gly Ile Glu Ser Gln Val Asp Val Met Gln Gln Ala Thr Asn Ala 
 865                870                875                880
Ile Leu Arg Gly Gly Pro Leu Leu Ala Pro Thr Val Ser Ala Lys Thr 
                 885                890                895
Ile Ala Glu Gln Leu Ala Glu Lys Ile Asn Ala Lys Leu Asn Tyr Val 
             900                905                910
Pro Leu Glu Lys Gln Glu Glu Glu Arg Gln Glu Gly Gly Gln Ser Glu 
         915                920                925
Ser Phe Lys Arg Tyr Glu Glu Glu Leu Glu Ile Asn Asp Phe Pro Gln 
     930                935                940
Thr Ala Arg Trp Lys Val Thr Ser Lys Glu Ala Leu Gln Arg Ile Ser 
 945                950                955                960
Glu Tyr Ser Glu Ala Ala Ile Thr Ile Arg Gly Thr Tyr Phe Pro Pro 
                 965                970                975
Gly Lys Glu Pro Lys Glu Gly Glu Arg Lys Ile Tyr Leu Ala Ile Glu 
             980                985                990
Ser Ala Asn Glu Leu Ala Val Gln Lys Ala Lys Ala Glu Ile Thr Arg 
         995                1000                1005
Leu Ile Lys Glu Glu Leu Ile Arg Leu Gln Asn Ser Tyr Gln Pro Thr 
     1010                1015                1020
Asn Lys Gly Arg Tyr Lys Val Leu Ter 
 1025                1030



<210> 8275
<211> 3746
<212> DNA
<213> Homo sapiens
<308> AF106680
<400> 8275

cccgcgctg  gatggccgc  acagctgta  gtgctgcta  tgtttagcg  tggtctttg  60
cgggcgttg  gggcagctc  gcctccttg  ttgtccggt  cgcctgtgc  tggtactca  120
gggcaccag  attcccgcg  tcggcagca  gggtcggga  tcacgccac  atcgaaaac  180
atcggcatc  cggggtcgc  ctggaagtc  gtctagaag  cgctcaccc  cagacaaaa  240
aagtaaacg  ggagatgac  gacggtcta  aagtagaga  agagatagg  ggagagaga  300
gtctcgtag  agggataaa  gaagatctc  gtcaaggga  aggaagcgt  tgagacgtt  360
cagaagtag  gagagagac  gaagccgag  gcgaagaag  tctcgaagt  gagacagga  420
acgctcaag  agtagaagc  ggggccggc  atcccgatc  tccagtcct  gcagcaaaa  480
caagaaggc  gagaacagg  ctaggtcca  agagaaagc  gaaggtggg  acagctcca  540
ggagaagaa  aaagacaag  acgacaagg  ggacgagaa  gagaaggat  ctgggaatt  600
tgaccagaa  aagctggaa  aagaaatga  aaaacgaaa  gaaagggtt  aaaaatggc  660
agaagagca  cgtaaaaag  cgatggaga  catagggga  ctgaagaag  agatcgagg  720
gatgaagca  gggaagaag  ggagcctgg  agatgacga  gatgatgaa  atgaccctg  780
cgaggctga  aaggaaggg  atgaaatgg  ggacgagga  ctggaccca  tagatgcct  840
catggagga  gtgaaagaa  aggtaaaaa  gtttaacat  aggagcgtg  aaggcggcg  900
aggaaatga  aagaagtcc  ggccaacgg  cacaaaagt  gtcactgtt  tgacaacca  960
aaaagcagt  gtggattct  ataagaaga  aggtgagct  atggagaat  accaggatg  1020
catggagta  tcttcagag  aggaagaag  tgatcttca  acagccctt  cagggtatc  1080
aacaaaaca  cgaaaactt  tagaaccag  tgatcatgg  aaaattgag  atgagccat  1140
taggaaaaa  ttctatgtt  aagttccag  actagcaaa  atgtctcaa  aagaggtaa  1200
tgtgtttcg  ttggaaatg  agggcatta  agttaaagg  aaaggttgc  ccaaaccaa  1260
taaatcctg  gtccagtgt  gaatttcca  gaagatctt  aattccctc  agaagcatg  1320
ctatgaaaa  cccacgccc  tccaaaccc  agctattcc  gctataatg  ctggacgag  1380
tttgattgg  attgccaaa  caggaagtg  aaagaccat  gcttttctg  tgcccatgt  1440
tagacacat  atggatcag  ggtcattag  ggaaggaga  gggccatta  ctgtcatca  1500
gactcccac  cgagaactg  ctttacaga  acctaaggg  gtaagaagt  tcaagactt  1560
gggacttag  gtggtctgt  tttacggag  aacaggaat  agtgagcag  ttgctgagc  1620
gaaaagagg  gctgaaatt  ttgtttgca  acctggtcg  atgattgac  tgttagccg  1680
taacagtgg  cgggtcaca  atcttcgaa  agtgacata  gttgtttta  atgaagcag  1740
cagaatgtt  gacatgggt  ttgaacccc  ggtcatgcg  atcgtggat  atgttcgtc  1800
tgatcgaca  acggttatg  tttcagcta  tttcccaag  gctatggaa  cgttggccc  1860
caggatctt  agcaagccc  ttgaagttc  ggttggagg  cggagtgtg  tttgctcag  1920
tgtggaaca  caagtgatt  tgattgaag  agagaagaa  ttcttgaaa  tgctggagc  1980
tttaggcca  tatcaggag  caggatctg  cattatatt  gtggataag  aggaacacg  2040
tgatggtct  ctgaaggat  taatgagag  atcttatcc  tgcatgtct  ttcatggag  2100
cattgatca  tatgacaga  atagcatca  aaatgactt  aagaatggg  cctgcaaac  2160
tcttgtggc  acctctgtt  ctgcccgag  tctagatgt  aaacatctg  ttcttgtag  2220
aaattatag  tgccccaac  attatgagg  ttatgtaca  agagcaggg  ggactggaa  2280
agcaggaaa  aagggttat  cttatactt  tatcacaga  gatcaagct  gctatgctg  2340
tgacataat  aaagctctt  aattgtcgg  gactgcggt  cctcctgac  tagagaaac  2400
atggagtga  ttcaaagat  agcagaaag  tgaaggaaa  ataattaaa  agagcagcg  2460
cttctctgg  aaggggttc  agtttgatg  gacagagca  gctttagcc  atgagagga  2520
aaagctaca  aaagctgcc  ttggcctgc  agattcaga  gatgaggat  ctgcagttg  2580
tattgatga  caaattgaa  gcatgttta  ttcaaagaa  agagtaaag  atatggctg  2640
tcctggaac  tcaagtgtt  ctgctccaa  tgcaggaaa  gctgagaaa  tagaaattg  2700
taagagatt  gctcttaga  tcaatgccc  gaagaattt  ggcatcgag  ctcaggtag  2760
tgtgatgca  caggccacc  atgcaattc  taggggtgg  accattctg  ctcccactg  2820
ttctgcaaa  accattgca  aacaacttg  tgaaaagat  aatgccaag  tcaattatg  2880
gccgttaga  aaacaagaa  aagagagac  ggatggtgg  cagaatgaa  cttttaaga  2940
atatgaaga  gaattagag  tcaatgact  cccacagac  gctaggtgg  aagttacct  3000
taaggaagc  ctgcagaga  tcagtgaat  ctctgaagc  gcaattaca  tcagaggaa  3060
ctacttccc  cctggcaaa  aacccaagg  aggcgagcg  aagatttac  tggcaattg  3120
aagtgccaa  gaactggct  tgcagaaag  aaaggcaga  atcaccagg  tcataaaag  3180
agagctgat  cggctgcaa  attcatacc  accaacaaa  aaaggaaga  acaaagtct  3240
atagacatc  ggaaaaaag  tttttacct  tgctggtct  tgatgtatg  ggcagttgc  3300
gtctgcagt  tacaatgta  tgtaaatga  gatttttta  attctatct  gctgatttt  3360
tttaaatat  agaaactgg  acttggtaa  gaaatctgt  cgtaagtac  cccacaatc  3420
gtcaaacta  atttaaagc  agcctgttt  cagagtatg  tgtccttta  tgtaaactc  3480
aatatcaat  ttttaaatg  ccggataat  ttctagagg  ttaaaaaat  gaaatattt  3540
aactttcta  tgaagacaa  aaagtacac  agtcgttaa  gggctattc  ctttatcct  3600
tactttcaa  gaaattgtg  tcatttcct  agaaaaggt  aaattcact  tcatatttt  3660
tgtccccac  ttgatgtta  atgactctg  aacaatatg  actggattt  agaatgtta  3720
aatagaagt  ttacaaaat  gaaaaa  3746



<210> 8276
<211> 1032
<212> PRT
<213> Homo sapiens
<308> BAA34521
<400> 8276

Met Gly Arg Glu Ser Arg His Tyr Arg Lys Arg Ser Ala Ser Arg Gly 
  1               5                  10                  15
Arg Ser Gly Ser Arg Ser Arg Ser Arg Ser Pro Ser Asp Lys Arg Ser 
             20                  25                  30
Lys Arg Gly Asp Asp Arg Arg Ser Arg Ser Arg Asp Arg Asp Arg Arg 
         35                  40                  45
Arg Glu Arg Ser Arg Ser Arg Asp Lys Arg Arg Ser Arg Ser Arg Asp 
     50                  55                  60
Arg Lys Arg Leu Arg Arg Ser Arg Ser Arg Glu Arg Asp Arg Ser Arg 
 65                  70                  75                  80
Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser Arg 
                 85                  90                  95
Ser Arg Gly Arg Arg Ser Arg Ser Ser Ser Pro Gly Asn Lys Ser Lys 
             100                105                110
Lys Thr Glu Asn Arg Ser Arg Ser Lys Glu Lys Thr Asp Gly Gly Glu 
         115                120                125
Ser Ser Lys Glu Lys Lys Lys Asp Lys Asp Asp Lys Glu Asp Glu Lys 
     130                135                140
Glu Lys Asp Ala Gly Asn Phe Asp Gln Asn Lys Leu Glu Glu Glu Met 
 145                150                155                160
Arg Lys Arg Lys Glu Arg Val Glu Lys Trp Arg Glu Glu Gln Arg Lys 
                 165                170                175
Lys Ala Met Glu Asn Ile Gly Glu Leu Lys Lys Glu Ile Glu Glu Met 
             180                185                190
Lys Gln Gly Lys Lys Trp Ser Leu Glu Asp Asp Asp Asp Asp Glu Asp 
         195                200                205
Asp Pro Ala Glu Ala Glu Lys Glu Gly Asn Glu Met Glu Gly Glu Glu 
     210                215                220
Leu Asp Pro Leu Asp Ala Tyr Met Glu Glu Val Lys Glu Glu Val Lys 
 225                230                235                240
Lys Phe Asn Met Arg Ser Val Lys Gly Gly Gly Gly Asn Glu Lys Lys 
                 245                250                255
Ser Gly Pro Thr Val Thr Lys Val Val Thr Val Val Thr Thr Lys Lys 
             260                265                270
Ala Val Val Asp Ser Asp Lys Lys Lys Gly Glu Leu Met Glu Asn Asp 
         275                280                285
Gln Asp Ala Met Glu Tyr Ser Ser Glu Glu Glu Glu Val Asp Leu Gln 
     290                295                300
Thr Ala Leu Thr Gly Tyr Gln Thr Lys Gln Arg Lys Leu Leu Glu Pro 
 305                310                315                320
Val Asp His Gly Lys Ile Glu Tyr Glu Pro Phe Arg Lys Asn Phe Tyr 
                 325                330                335
Val Glu Val Pro Glu Leu Ala Lys Met Ser Gln Glu Glu Val Asn Val 
             340                345                350
Phe Arg Leu Glu Met Glu Gly Ile Thr Val Lys Gly Lys Gly Cys Pro 
         355                360                365
Lys Pro Ile Lys Ser Trp Val Gln Cys Gly Ile Ser Met Lys Ile Leu 
     370                375                380
Asn Ser Leu Lys Lys His Gly Tyr Glu Lys Pro Thr Pro Ile Gln Thr 
 385                390                395                400
Gln Ala Ile Pro Ala Ile Met Ser Gly Arg Asp Leu Ile Gly Ile Ala 
                 405                410                415
Lys Thr Gly Ser Gly Lys Thr Ile Ala Phe Leu Leu Pro Met Phe Arg 
             420                425                430
His Ile Met Asp Gln Arg Ser Leu Glu Glu Gly Glu Gly Pro Ile Ala 
         435                440                445
Val Ile Met Thr Pro Thr Arg Glu Leu Ala Leu Gln Ile Thr Lys Glu 
     450                455                460
Cys Lys Lys Phe Ser Lys Thr Leu Gly Leu Arg Val Val Cys Val Tyr 
 465                470                475                480
Gly Gly Thr Gly Ile Ser Glu Gln Ile Ala Glu Leu Lys Arg Gly Ala 
                 485                490                495
Glu Ile Ile Val Cys Thr Pro Gly Arg Met Ile Asp Met Leu Ala Ala 
             500                505                510
Asn Ser Gly Arg Val Thr Asn Leu Arg Arg Val Thr Tyr Val Val Leu 
         515                520                525
Asp Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Pro Gln Val Met 
     530                535                540
Arg Ile Val Asp Asn Val Arg Pro Asp Arg Gln Thr Val Met Phe Ser 
 545                550                555                560
Ala Thr Phe Pro Arg Ala Met Glu Ala Leu Ala Arg Arg Ile Leu Ser 
                 565                570                575
Lys Pro Ile Glu Val Gln Val Gly Gly Arg Ser Val Val Cys Ser Asp 
             580                585                590
Val Glu Gln Gln Val Ile Val Ile Glu Glu Glu Lys Lys Phe Leu Lys 
         595                600                605
Leu Leu Glu Leu Leu Gly His Tyr Gln Glu Ser Gly Ser Val Ile Ile 
     610                615                620
Phe Val Asp Lys Gln Glu His Ala Asp Gly Leu Leu Lys Asp Leu Met 
 625                630                635                640
Arg Ala Ser Tyr Pro Cys Met Ser Leu His Gly Gly Ile Asp Gln Tyr 
                 645                650                655
Asp Arg Asp Ser Ile Ile Asn Asp Phe Lys Asn Gly Thr Cys Lys Leu 
             660                665                670
Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Val Lys His Leu 
         675                680                685
Ile Leu Val Val Asn Tyr Ser Cys Pro Asn His Tyr Glu Asp Tyr Val 
     690                695                700
His Arg Ala Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Tyr Ala Tyr 
 705                710                715                720
Thr Phe Ile Thr Glu Asp Gln Ala Arg Tyr Ala Gly Asp Ile Ile Lys 
                 725                730                735
Ala Leu Glu Leu Ser Gly Thr Ala Val Pro Pro Asp Leu Glu Lys Leu 
             740                745                750
Trp Ser Asp Phe Lys Asp Gln Gln Lys Ala Glu Gly Lys Ile Ile Lys 
         755                760                765
Lys Ser Ser Gly Phe Ser Gly Lys Gly Phe Lys Phe Asp Glu Thr Glu 
     770                775                780
Gln Ala Leu Ala Asn Glu Arg Lys Lys Leu Gln Lys Ala Ala Leu Gly 
 785                790                795                800
Leu Gln Asp Ser Asp Asp Glu Asp Ala Ala Val Asp Ile Asp Glu Gln 
                 805                810                815
Ile Glu Ser Met Phe Asn Ser Lys Lys Arg Val Lys Asp Met Ala Ala 
             820                825                830
Pro Gly Thr Ser Ser Val Pro Ala Pro Thr Ala Gly Asn Ala Glu Lys 
         835                840                845
Leu Glu Ile Ala Lys Arg Leu Ala Leu Arg Ile Asn Ala Gln Lys Asn 
     850                855                860
Leu Gly Ile Glu Ser Gln Val Asp Val Met Gln Gln Ala Thr Asn Ala 
 865                870                875                880
Ile Leu Arg Gly Gly Thr Ile Leu Ala Pro Thr Val Ser Ala Lys Thr 
                 885                890                895
Ile Ala Glu Gln Leu Ala Glu Lys Ile Asn Ala Lys Leu Asn Tyr Val 
             900                905                910
Pro Leu Glu Lys Gln Glu Glu Glu Arg Gln Asp Gly Gly Gln Asn Glu 
         915                920                925
Ser Phe Lys Arg Tyr Glu Glu Glu Leu Glu Ile Asn Asp Phe Pro Gln 
     930                935                940
Thr Ala Arg Trp Lys Val Thr Ser Lys Glu Ala Leu Gln Arg Ile Ser 
 945                950                955                960
Glu Tyr Ser Glu Ala Ala Ile Thr Ile Arg Gly Thr Tyr Phe Pro Pro 
                 965                970                975
Gly Lys Glu Pro Lys Glu Gly Glu Arg Lys Ile Tyr Leu Ala Ile Glu 
             980                985                990
Ser Ala Asn Glu Leu Ala Val Gln Lys Ala Lys Ala Glu Ile Thr Arg 
         995                1000                1005
Leu Ile Lys Glu Glu Leu Ile Arg Leu Gln Asn Ser Tyr Gln Pro Thr 
     1010                1015                1020
Asn Lys Gly Arg Tyr Lys Val Leu 
 1025                1030



<210> 8277
<211> 3531
<212> DNA
<213> Rattus norvegicus
<308> U25746
<400> 8277

cacgctctg  tggcggtca  tgctggagc  ttggccatt  cgtagggcc  gtcctcgct  60
ggtactgtg  ggacttggt  cctccctcc  ttgtcctct  caccggtct  cgcatcgtc  120
ccaagggcg  aggccttcc  ctggctggc  gcatgggca  ggagtctcg  cattaccga  180
aacggtcag  atctcgagg  cgctctgga  gtcggtcta  gagtcgctc  ccctctgac  240
aaagaagca  acgtggaga  gacaggcgt  ccaggagta  agacagaga  agaaggaga  300
agaggtctc  gagcaggga  aaaaggaga  ctcggtcac  ggacaggaa  cgcctgaga  360
gttccagaa  tagagagcg  gacagaagc  gagagcgaa  aagatctcg  agccgggat  420
gaaggcgct  aaggagtcg  agccggggc  ggcggtccc  gtcttccag  cctggcagc  480
aaagcaaga  ggctgagaa  aggtctagg  ccaaagaga  agcagaagg  ggggacagc  540
ccaaggaga  gaagaaaga  aaggacgac  aggaggacg  gaaagagaa  gatgctggg  600
attttgacc  gaataagct  gaagaagaa  tgagaaaac  aaaagaaag  gttgaaaaa  660
ggcgagaag  gcagcgtaa  aaggcgatg  agaacatag  ggagctgaa  aaggagatc  720
aggagatga  gcaggggaa  aagtggagc  tggaagatg  cgacgatga  gaagatgac  780
ctgccgagg  tgagaagga  gggaatgaa  tggaggacg  ggagctgga  ccattagat  840
cctacatgg  ggaagtgaa  gaagaggta  aaaagttta  catgaggag  gtgaaaggc  900
gcgcaggaa  tgagaagaa  tccggaccg  ctgtcacga  agtggttac  gtggtaaca  960
ccaagaaag  agtagtaga  gccgacaag  agaagggag  gctgatgga  aatgaccag  1020
acgccatgg  gtactcctc  gaggaggaa  aggttgacc  tcagacggc  ctcacaggc  1080
accagacaa  acagagaaa  cttctagag  cagtggatc  tgggaaaat  gagtatgag  1140
cattcagaa  aaactttta  gttgaagtt  cagaattag  gaaaatgtc  caagaagag  1200
tgaatgtgt  tcggttgga  atggagggc  ttacagtta  aggaaaagg  tgccccaag  1260
caattaaat  atgggtcca  tgtggaatt  ccatgaaga  actgaattc  ctcaaaaag  1320
atggctatg  aaagcccac  ccaatccaa  ctcaagcaa  tcctgctat  atgtctgga  1380
gagatttga  tggcattgc  aagacagga  gtggaaaaa  cattgcttt  cttttgccc  1440
tgtttagac  catcatgga  cagaggtca  tggaagaag  agagggacc  atcgctgtc  1500
tcatgactc  aactcgaga  ctggcttta  aaatcacta  agaatgtaa  aagttttcg  1560
agaccttgg  actgagagt  gtctgtgtg  atggaggga  aggaatcag  gagcagatt  1620
ctgagctga  gagaggcgc  gagatcatt  tttgcacac  tggccggat  atcgacatg  1680
tggcagcta  cagtggtcg  gtcacaaat  ttcgaagag  gacatatgt  gttttagat  1740
aagcagaca  aatgtttga  atgggtttt  aaccacagg  catgcgcat  gtggacaat  1800
tccgtcctg  ccgacagac  gttatgttc  cagctactt  cccaagagc  atggaagcg  1860
tggcccgca  gatcttgag  aagcccatt  aagttcagg  tggaggccg  agtgtggtt  1920
gctcagatg  ggaacaaca  gtgattgtg  ttgaagaag  gaagaaatt  ttgaaattg  1980
tggagcttt  aggccatta  caggagtca  gatctgtca  tatatttgt  gataagcag  2040
aacacgctg  tggtcttct  aaggacttg  tgagagctt  ctacccttg  atgtctctt  2100
acggaggta  tgatcagta  gacagggac  gtatcataa  tgactttaa  aatggaacc  2160
gcaaacttc  cgtagccac  tctgttgcc  cccgtggtc  agatgtgaa  catctcatt  2220
ttgtagtaa  ttacagctg  cccaatcat  acgaagatt  cgtgcacag  gctgggcgg  2280
ctggaagag  aggcaacaa  ggttatgcc  acaccttca  cacagaaga  caagctcga  2340
atgctgggg  catcattaa  gctcttgaa  tgtcgggga  ggcggtgcc  cctgaccta  2400
agaaactat  gagtgactt  aaagatcag  agaaagctg  aggaaaaat  attaaaaag  2460
gcagcggct  ctctggcaa  gggttcaag  ttgatgaga  agagcaggc  ttagccaat  2520
agaggaaaa  gctacaaaa  gctgccctt  gcctgcagg  ttctgatga  gaggacgcc  2580
cagttgata  tgacgagca  attgaaagc  tgtttaatt  caagaagag  gtgaaagac  2640
tggctgctc  cggcacatc  agtgcgcct  ctccgactg  gggcaatgc  gagaagcta  2700
agattgcca  gaggttggc  cttagaatc  acgctcaga  gaacctggg  atcgagtct  2760
aggtagatg  gatgcagca  gccacaaat  ccatcctca  aggtggccc  cttctggct  2820
ccaccgtgt  tgcaaaaac  atcgcagag  agcttgccg  gaagatcaa  gccaagctc  2880
attacgtgc  tttggagaa  caggaagaa  agagacagg  gggtgggca  agcgaatct  2940
tcaagagat  cgaggaaga  ttagaaatt  atgacttcc  acagacggc  aggtggaaa  3000
ttacctcta  ggaagcctt  cagaggatc  gtgagtact  ggaagccgc  atcacaatc  3060
gagggacct  cttcccgcc  ggcaaagag  ccaaggaag  agagcggaa  atctacttg  3120
cgattgaaa  tgccaacga  ctggctgtg  agaaagcaa  ggcagagat  accaggctc  3180
taaaagagg  gctgatccg  ctgcaaaat  cataccaac  caccaacaa  ggacgatac  3240
aagtattat  aacaccgga  ccactttgt  cccgtgcta  ctgtgacgt  tacagtgta  3300
tgtaaagta  gacttttaa  attctgtct  gcttatttt  taagtacaa  aaaccagtg  3360
ttgttcaag  ggtcatctg  aagtactac  ctataccca  ccaaactcc  tttaaatca  3420
agctgtttt  agagtgtga  gttcttcga  gtaaacctt  gataccaac  ctttaaata  3480
ctggagaca  tgggatttt  tactgaatg  agtaataaa  tgtgtcagg  a  3531



<210> 8278
<211> 1033
<212> PRT
<213> Rattus norvegicus
<308> U25746
<400> 8278

Met Gly Arg Glu Ser Arg His Tyr Arg Lys Arg Ser Ala Ser Arg Gly 
  1               5                  10                  15
Arg Ser Gly Ser Arg Ser Arg Ser Arg Ser Pro Ser Asp Lys Arg Ser 
             20                  25                  30
Lys Arg Gly Asp Asp Arg Arg Ser Arg Ser Arg Asp Arg Asp Arg Arg 
         35                  40                  45
Arg Glu Arg Ser Arg Ser Arg Asp Lys Arg Arg Ser Arg Ser Arg Asp 
     50                  55                  60
Arg Lys Arg Leu Arg Arg Ser Arg Ser Arg Glu Arg Asp Arg Ser Arg 
 65                  70                  75                  80
Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser Arg 
                 85                  90                  95
Ser Arg Gly Arg Arg Ser Arg Ser Ser Ser Pro Gly Ser Lys Ser Lys 
             100                105                110
Lys Ala Glu Asn Arg Ser Arg Ser Lys Glu Lys Ala Glu Gly Gly Asp 
         115                120                125
Ser Ser Lys Glu Lys Lys Lys Asp Lys Asp Asp Lys Glu Asp Glu Lys 
     130                135                140
Glu Lys Asp Ala Gly Asn Phe Asp Gln Asn Lys Leu Glu Glu Glu Met 
 145                150                155                160
Arg Lys Arg Lys Glu Arg Val Glu Lys Trp Arg Glu Glu Gln Arg Lys 
                 165                170                175
Lys Ala Met Glu Asn Ile Gly Glu Leu Lys Lys Glu Ile Glu Glu Met 
             180                185                190
Lys Gln Gly Lys Lys Trp Ser Leu Glu Asp Asp Asp Asp Asp Glu Asp 
         195                200                205
Asp Pro Ala Glu Ala Glu Lys Glu Gly Asn Glu Met Glu Asp Glu Glu 
     210                215                220
Leu Asp Pro Leu Asp Ala Tyr Met Glu Glu Val Lys Glu Glu Val Lys 
 225                230                235                240
Lys Phe Asn Met Arg Ser Val Lys Gly Gly Ala Gly Asn Glu Lys Lys 
                 245                250                255
Ser Gly Pro Thr Val Thr Lys Val Val Thr Val Val Thr Thr Lys Lys 
             260                265                270
Ala Val Val Asp Ala Asp Lys Lys Lys Gly Glu Leu Met Glu Asn Asp 
         275                280                285
Gln Asp Ala Met Glu Tyr Ser Ser Glu Glu Glu Glu Val Asp Leu Gln 
     290                295                300
Thr Ala Leu Thr Gly Tyr Gln Thr Lys Gln Arg Lys Leu Leu Glu Pro 
 305                310                315                320
Val Asp His Gly Lys Ile Glu Tyr Glu Pro Phe Arg Lys Asn Phe Tyr 
                 325                330                335
Val Glu Val Pro Glu Leu Ala Lys Met Ser Gln Glu Glu Val Asn Val 
             340                345                350
Phe Arg Leu Glu Met Glu Gly Ile Thr Val Lys Gly Lys Gly Cys Pro 
         355                360                365
Lys Pro Ile Lys Ser Trp Val Gln Cys Gly Ile Ser Met Lys Ile Leu 
     370                375                380
Asn Ser Leu Lys Lys His Gly Tyr Glu Lys Pro Thr Pro Ile Gln Thr 
 385                390                395                400
Gln Ala Ile Pro Ala Ile Met Ser Gly Arg Asp Leu Ile Gly Ile Ala 
                 405                410                415
Lys Thr Gly Ser Gly Lys Thr Ile Ala Phe Leu Leu Pro Met Phe Arg 
             420                425                430
His Ile Met Asp Gln Arg Ser Leu Glu Glu Gly Glu Gly Pro Ile Ala 
         435                440                445
Val Ile Met Thr Pro Thr Arg Glu Leu Ala Leu Gln Ile Thr Lys Glu 
     450                455                460
Cys Lys Lys Phe Ser Lys Thr Leu Gly Leu Arg Val Val Cys Val Tyr 
 465                470                475                480
Gly Gly Thr Gly Ile Ser Glu Gln Ile Ala Glu Leu Lys Arg Gly Ala 
                 485                490                495
Glu Ile Ile Val Cys Thr Pro Gly Arg Met Ile Asp Met Leu Ala Ala 
             500                505                510
Asn Ser Gly Arg Val Thr Asn Leu Arg Arg Val Thr Tyr Val Val Leu 
         515                520                525
Asp Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Pro Gln Val Met 
     530                535                540
Arg Ile Val Asp Asn Val Arg Pro Asp Arg Gln Thr Val Met Phe Ser 
 545                550                555                560
Ala Thr Phe Pro Arg Ala Met Glu Ala Leu Ala Arg Arg Ile Leu Ser 
                 565                570                575
Lys Pro Ile Glu Val Gln Val Gly Gly Arg Ser Val Val Cys Ser Asp 
             580                585                590
Val Glu Gln Gln Val Ile Val Ile Glu Glu Glu Lys Lys Phe Leu Lys 
         595                600                605
Leu Leu Glu Leu Leu Gly His Tyr Gln Glu Ser Gly Ser Val Ile Ile 
     610                615                620
Phe Val Asp Lys Gln Glu His Ala Asp Gly Leu Leu Lys Asp Leu Met 
 625                630                635                640
Arg Ala Ser Tyr Pro Cys Met Ser Leu His Gly Gly Ile Asp Gln Tyr 
                 645                650                655
Asp Arg Asp Ser Ile Ile Asn Asp Phe Lys Asn Gly Thr Cys Lys Leu 
             660                665                670
Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Val Lys His Leu 
         675                680                685
Ile Leu Val Val Asn Tyr Ser Cys Pro Asn His Tyr Glu Asp Tyr Val 
     690                695                700
His Arg Ala Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Tyr Ala Tyr 
 705                710                715                720
Thr Phe Ile Thr Glu Asp Gln Ala Arg Tyr Ala Gly Asp Ile Ile Lys 
                 725                730                735
Ala Leu Glu Leu Ser Gly Thr Ala Val Pro Pro Asp Leu Glu Lys Leu 
             740                745                750
Trp Ser Asp Phe Lys Asp Gln Gln Lys Ala Glu Gly Lys Ile Ile Lys 
         755                760                765
Lys Ser Ser Gly Phe Ser Gly Lys Gly Phe Lys Phe Asp Glu Thr Glu 
     770                775                780
Gln Ala Leu Ala Asn Glu Arg Lys Lys Leu Gln Lys Ala Ala Leu Gly 
 785                790                795                800
Leu Gln Asp Ser Asp Asp Glu Asp Ala Ala Val Asp Ile Asp Glu Gln 
                 805                810                815
Ile Glu Ser Met Phe Asn Ser Lys Lys Arg Val Lys Asp Met Ala Ala 
             820                825                830
Pro Gly Thr Ser Ser Ala Pro Ala Pro Thr Ala Gly Asn Ala Glu Lys 
         835                840                845
Leu Glu Ile Ala Lys Arg Leu Ala Leu Arg Ile Asn Ala Gln Lys Asn 
     850                855                860
Leu Gly Ile Glu Ser Gln Val Asp Val Met Gln Gln Ala Thr Asn Ala 
 865                870                875                880
Ile Leu Arg Gly Gly Pro Leu Leu Ala Pro Thr Val Ser Ala Lys Thr 
                 885                890                895
Ile Ala Glu Gln Leu Ala Glu Lys Ile Asn Ala Lys Leu Asn Tyr Val 
             900                905                910
Pro Leu Glu Lys Gln Glu Glu Glu Arg Gln Glu Gly Gly Gln Ser Glu 
         915                920                925
Ser Phe Lys Arg Tyr Glu Glu Glu Leu Glu Ile Asn Asp Phe Pro Gln 
     930                935                940
Thr Ala Arg Trp Lys Val Thr Ser Lys Glu Ala Leu Gln Arg Ile Ser 
 945                950                955                960
Glu Tyr Ser Glu Ala Ala Ile Thr Ile Arg Gly Thr Tyr Phe Pro Pro 
                 965                970                975
Gly Lys Glu Pro Lys Glu Gly Glu Arg Lys Ile Tyr Leu Ala Ile Glu 
             980                985                990
Ser Ala Asn Glu Leu Ala Val Gln Lys Ala Lys Ala Glu Ile Thr Arg 
         995                1000                1005
Leu Ile Lys Glu Glu Leu Ile Arg Leu Gln Asn Ser Tyr Gln Pro Thr 
     1010                1015                1020
Asn Lys Gly Arg Tyr Lys Val Leu Ter 
 1025                1030



<210> 8279
<211> 3746
<212> DNA
<213> Homo sapiens
<308> AF106680
<400> 8279

cccgcgctg  gatggccgc  acagctgta  gtgctgcta  tgtttagcg  tggtctttg  60
cgggcgttg  gggcagctc  gcctccttg  ttgtccggt  cgcctgtgc  tggtactca  120
gggcaccag  attcccgcg  tcggcagca  gggtcggga  tcacgccac  atcgaaaac  180
atcggcatc  cggggtcgc  ctggaagtc  gtctagaag  cgctcaccc  cagacaaaa  240
aagtaaacg  ggagatgac  gacggtcta  aagtagaga  agagatagg  ggagagaga  300
gtctcgtag  agggataaa  gaagatctc  gtcaaggga  aggaagcgt  tgagacgtt  360
cagaagtag  gagagagac  gaagccgag  gcgaagaag  tctcgaagt  gagacagga  420
acgctcaag  agtagaagc  ggggccggc  atcccgatc  tccagtcct  gcagcaaaa  480
caagaaggc  gagaacagg  ctaggtcca  agagaaagc  gaaggtggg  acagctcca  540
ggagaagaa  aaagacaag  acgacaagg  ggacgagaa  gagaaggat  ctgggaatt  600
tgaccagaa  aagctggaa  aagaaatga  aaaacgaaa  gaaagggtt  aaaaatggc  660
agaagagca  cgtaaaaag  cgatggaga  catagggga  ctgaagaag  agatcgagg  720
gatgaagca  gggaagaag  ggagcctgg  agatgacga  gatgatgaa  atgaccctg  780
cgaggctga  aaggaaggg  atgaaatgg  ggacgagga  ctggaccca  tagatgcct  840
catggagga  gtgaaagaa  aggtaaaaa  gtttaacat  aggagcgtg  aaggcggcg  900
aggaaatga  aagaagtcc  ggccaacgg  cacaaaagt  gtcactgtt  tgacaacca  960
aaaagcagt  gtggattct  ataagaaga  aggtgagct  atggagaat  accaggatg  1020
catggagta  tcttcagag  aggaagaag  tgatcttca  acagccctt  cagggtatc  1080
aacaaaaca  cgaaaactt  tagaaccag  tgatcatgg  aaaattgag  atgagccat  1140
taggaaaaa  ttctatgtt  aagttccag  actagcaaa  atgtctcaa  aagaggtaa  1200
tgtgtttcg  ttggaaatg  agggcatta  agttaaagg  aaaggttgc  ccaaaccaa  1260
taaatcctg  gtccagtgt  gaatttcca  gaagatctt  aattccctc  agaagcatg  1320
ctatgaaaa  cccacgccc  tccaaaccc  agctattcc  gctataatg  ctggacgag  1380
tttgattgg  attgccaaa  caggaagtg  aaagaccat  gcttttctg  tgcccatgt  1440
tagacacat  atggatcag  ggtcattag  ggaaggaga  gggccatta  ctgtcatca  1500
gactcccac  cgagaactg  ctttacaga  acctaaggg  gtaagaagt  tcaagactt  1560
gggacttag  gtggtctgt  tttacggag  aacaggaat  agtgagcag  ttgctgagc  1620
gaaaagagg  gctgaaatt  ttgtttgca  acctggtcg  atgattgac  tgttagccg  1680
taacagtgg  cgggtcaca  atcttcgaa  agtgacata  gttgtttta  atgaagcag  1740
cagaatgtt  gacatgggt  ttgaacccc  ggtcatgcg  atcgtggat  atgttcgtc  1800
tgatcgaca  acggttatg  tttcagcta  tttcccaag  gctatggaa  cgttggccc  1860
caggatctt  agcaagccc  ttgaagttc  ggttggagg  cggagtgtg  tttgctcag  1920
tgtggaaca  caagtgatt  tgattgaag  agagaagaa  ttcttgaaa  tgctggagc  1980
tttaggcca  tatcaggag  caggatctg  cattatatt  gtggataag  aggaacacg  2040
tgatggtct  ctgaaggat  taatgagag  atcttatcc  tgcatgtct  ttcatggag  2100
cattgatca  tatgacaga  atagcatca  aaatgactt  aagaatggg  cctgcaaac  2160
tcttgtggc  acctctgtt  ctgcccgag  tctagatgt  aaacatctg  ttcttgtag  2220
aaattatag  tgccccaac  attatgagg  ttatgtaca  agagcaggg  ggactggaa  2280
agcaggaaa  aagggttat  cttatactt  tatcacaga  gatcaagct  gctatgctg  2340
tgacataat  aaagctctt  aattgtcgg  gactgcggt  cctcctgac  tagagaaac  2400
atggagtga  ttcaaagat  agcagaaag  tgaaggaaa  ataattaaa  agagcagcg  2460
cttctctgg  aaggggttc  agtttgatg  gacagagca  gctttagcc  atgagagga  2520
aaagctaca  aaagctgcc  ttggcctgc  agattcaga  gatgaggat  ctgcagttg  2580
tattgatga  caaattgaa  gcatgttta  ttcaaagaa  agagtaaag  atatggctg  2640
tcctggaac  tcaagtgtt  ctgctccaa  tgcaggaaa  gctgagaaa  tagaaattg  2700
taagagatt  gctcttaga  tcaatgccc  gaagaattt  ggcatcgag  ctcaggtag  2760
tgtgatgca  caggccacc  atgcaattc  taggggtgg  accattctg  ctcccactg  2820
ttctgcaaa  accattgca  aacaacttg  tgaaaagat  aatgccaag  tcaattatg  2880
gccgttaga  aaacaagaa  aagagagac  ggatggtgg  cagaatgaa  cttttaaga  2940
atatgaaga  gaattagag  tcaatgact  cccacagac  gctaggtgg  aagttacct  3000
taaggaagc  ctgcagaga  tcagtgaat  ctctgaagc  gcaattaca  tcagaggaa  3060
ctacttccc  cctggcaaa  aacccaagg  aggcgagcg  aagatttac  tggcaattg  3120
aagtgccaa  gaactggct  tgcagaaag  aaaggcaga  atcaccagg  tcataaaag  3180
agagctgat  cggctgcaa  attcatacc  accaacaaa  aaaggaaga  acaaagtct  3240
atagacatc  ggaaaaaag  tttttacct  tgctggtct  tgatgtatg  ggcagttgc  3300
gtctgcagt  tacaatgta  tgtaaatga  gatttttta  attctatct  gctgatttt  3360
tttaaatat  agaaactgg  acttggtaa  gaaatctgt  cgtaagtac  cccacaatc  3420
gtcaaacta  atttaaagc  agcctgttt  cagagtatg  tgtccttta  tgtaaactc  3480
aatatcaat  ttttaaatg  ccggataat  ttctagagg  ttaaaaaat  gaaatattt  3540
aactttcta  tgaagacaa  aaagtacac  agtcgttaa  gggctattc  ctttatcct  3600
tactttcaa  gaaattgtg  tcatttcct  agaaaaggt  aaattcact  tcatatttt  3660
tgtccccac  ttgatgtta  atgactctg  aacaatatg  actggattt  agaatgtta  3720
aatagaagt  ttacaaaat  gaaaaa  3746



<210> 8280
<211> 1032
<212> PRT
<213> Homo sapiens
<308> BAA34521
<400> 8280

Met Gly Arg Glu Ser Arg His Tyr Arg Lys Arg Ser Ala Ser Arg Gly 
  1               5                  10                  15
Arg Ser Gly Ser Arg Ser Arg Ser Arg Ser Pro Ser Asp Lys Arg Ser 
             20                  25                  30
Lys Arg Gly Asp Asp Arg Arg Ser Arg Ser Arg Asp Arg Asp Arg Arg 
         35                  40                  45
Arg Glu Arg Ser Arg Ser Arg Asp Lys Arg Arg Ser Arg Ser Arg Asp 
     50                  55                  60
Arg Lys Arg Leu Arg Arg Ser Arg Ser Arg Glu Arg Asp Arg Ser Arg 
 65                  70                  75                  80
Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser Arg 
                 85                  90                  95
Ser Arg Gly Arg Arg Ser Arg Ser Ser Ser Pro Gly Asn Lys Ser Lys 
             100                105                110
Lys Thr Glu Asn Arg Ser Arg Ser Lys Glu Lys Thr Asp Gly Gly Glu 
         115                120                125
Ser Ser Lys Glu Lys Lys Lys Asp Lys Asp Asp Lys Glu Asp Glu Lys 
     130                135                140
Glu Lys Asp Ala Gly Asn Phe Asp Gln Asn Lys Leu Glu Glu Glu Met 
 145                150                155                160
Arg Lys Arg Lys Glu Arg Val Glu Lys Trp Arg Glu Glu Gln Arg Lys 
                 165                170                175
Lys Ala Met Glu Asn Ile Gly Glu Leu Lys Lys Glu Ile Glu Glu Met 
             180                185                190
Lys Gln Gly Lys Lys Trp Ser Leu Glu Asp Asp Asp Asp Asp Glu Asp 
         195                200                205
Asp Pro Ala Glu Ala Glu Lys Glu Gly Asn Glu Met Glu Gly Glu Glu 
     210                215                220
Leu Asp Pro Leu Asp Ala Tyr Met Glu Glu Val Lys Glu Glu Val Lys 
 225                230                235                240
Lys Phe Asn Met Arg Ser Val Lys Gly Gly Gly Gly Asn Glu Lys Lys 
                 245                250                255
Ser Gly Pro Thr Val Thr Lys Val Val Thr Val Val Thr Thr Lys Lys 
             260                265                270
Ala Val Val Asp Ser Asp Lys Lys Lys Gly Glu Leu Met Glu Asn Asp 
         275                280                285
Gln Asp Ala Met Glu Tyr Ser Ser Glu Glu Glu Glu Val Asp Leu Gln 
     290                295                300
Thr Ala Leu Thr Gly Tyr Gln Thr Lys Gln Arg Lys Leu Leu Glu Pro 
 305                310                315                320
Val Asp His Gly Lys Ile Glu Tyr Glu Pro Phe Arg Lys Asn Phe Tyr 
                 325                330                335
Val Glu Val Pro Glu Leu Ala Lys Met Ser Gln Glu Glu Val Asn Val 
             340                345                350
Phe Arg Leu Glu Met Glu Gly Ile Thr Val Lys Gly Lys Gly Cys Pro 
         355                360                365
Lys Pro Ile Lys Ser Trp Val Gln Cys Gly Ile Ser Met Lys Ile Leu 
     370                375                380
Asn Ser Leu Lys Lys His Gly Tyr Glu Lys Pro Thr Pro Ile Gln Thr 
 385                390                395                400
Gln Ala Ile Pro Ala Ile Met Ser Gly Arg Asp Leu Ile Gly Ile Ala 
                 405                410                415
Lys Thr Gly Ser Gly Lys Thr Ile Ala Phe Leu Leu Pro Met Phe Arg 
             420                425                430
His Ile Met Asp Gln Arg Ser Leu Glu Glu Gly Glu Gly Pro Ile Ala 
         435                440                445
Val Ile Met Thr Pro Thr Arg Glu Leu Ala Leu Gln Ile Thr Lys Glu 
     450                455                460
Cys Lys Lys Phe Ser Lys Thr Leu Gly Leu Arg Val Val Cys Val Tyr 
 465                470                475                480
Gly Gly Thr Gly Ile Ser Glu Gln Ile Ala Glu Leu Lys Arg Gly Ala 
                 485                490                495
Glu Ile Ile Val Cys Thr Pro Gly Arg Met Ile Asp Met Leu Ala Ala 
             500                505                510
Asn Ser Gly Arg Val Thr Asn Leu Arg Arg Val Thr Tyr Val Val Leu 
         515                520                525
Asp Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Pro Gln Val Met 
     530                535                540
Arg Ile Val Asp Asn Val Arg Pro Asp Arg Gln Thr Val Met Phe Ser 
 545                550                555                560
Ala Thr Phe Pro Arg Ala Met Glu Ala Leu Ala Arg Arg Ile Leu Ser 
                 565                570                575
Lys Pro Ile Glu Val Gln Val Gly Gly Arg Ser Val Val Cys Ser Asp 
             580                585                590
Val Glu Gln Gln Val Ile Val Ile Glu Glu Glu Lys Lys Phe Leu Lys 
         595                600                605
Leu Leu Glu Leu Leu Gly His Tyr Gln Glu Ser Gly Ser Val Ile Ile 
     610                615                620
Phe Val Asp Lys Gln Glu His Ala Asp Gly Leu Leu Lys Asp Leu Met 
 625                630                635                640
Arg Ala Ser Tyr Pro Cys Met Ser Leu His Gly Gly Ile Asp Gln Tyr 
                 645                650                655
Asp Arg Asp Ser Ile Ile Asn Asp Phe Lys Asn Gly Thr Cys Lys Leu 
             660                665                670
Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Val Lys His Leu 
         675                680                685
Ile Leu Val Val Asn Tyr Ser Cys Pro Asn His Tyr Glu Asp Tyr Val 
     690                695                700
His Arg Ala Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Tyr Ala Tyr 
 705                710                715                720
Thr Phe Ile Thr Glu Asp Gln Ala Arg Tyr Ala Gly Asp Ile Ile Lys 
                 725                730                735
Ala Leu Glu Leu Ser Gly Thr Ala Val Pro Pro Asp Leu Glu Lys Leu 
             740                745                750
Trp Ser Asp Phe Lys Asp Gln Gln Lys Ala Glu Gly Lys Ile Ile Lys 
         755                760                765
Lys Ser Ser Gly Phe Ser Gly Lys Gly Phe Lys Phe Asp Glu Thr Glu 
     770                775                780
Gln Ala Leu Ala Asn Glu Arg Lys Lys Leu Gln Lys Ala Ala Leu Gly 
 785                790                795                800
Leu Gln Asp Ser Asp Asp Glu Asp Ala Ala Val Asp Ile Asp Glu Gln 
                 805                810                815
Ile Glu Ser Met Phe Asn Ser Lys Lys Arg Val Lys Asp Met Ala Ala 
             820                825                830
Pro Gly Thr Ser Ser Val Pro Ala Pro Thr Ala Gly Asn Ala Glu Lys 
         835                840                845
Leu Glu Ile Ala Lys Arg Leu Ala Leu Arg Ile Asn Ala Gln Lys Asn 
     850                855                860
Leu Gly Ile Glu Ser Gln Val Asp Val Met Gln Gln Ala Thr Asn Ala 
 865                870                875                880
Ile Leu Arg Gly Gly Thr Ile Leu Ala Pro Thr Val Ser Ala Lys Thr 
                 885                890                895
Ile Ala Glu Gln Leu Ala Glu Lys Ile Asn Ala Lys Leu Asn Tyr Val 
             900                905                910
Pro Leu Glu Lys Gln Glu Glu Glu Arg Gln Asp Gly Gly Gln Asn Glu 
         915                920                925
Ser Phe Lys Arg Tyr Glu Glu Glu Leu Glu Ile Asn Asp Phe Pro Gln 
     930                935                940
Thr Ala Arg Trp Lys Val Thr Ser Lys Glu Ala Leu Gln Arg Ile Ser 
 945                950                955                960
Glu Tyr Ser Glu Ala Ala Ile Thr Ile Arg Gly Thr Tyr Phe Pro Pro 
                 965                970                975
Gly Lys Glu Pro Lys Glu Gly Glu Arg Lys Ile Tyr Leu Ala Ile Glu 
             980                985                990
Ser Ala Asn Glu Leu Ala Val Gln Lys Ala Lys Ala Glu Ile Thr Arg 
         995                1000                1005
Leu Ile Lys Glu Glu Leu Ile Arg Leu Gln Asn Ser Tyr Gln Pro Thr 
     1010                1015                1020
Asn Lys Gly Arg Tyr Lys Val Leu 
 1025                1030



<210> 8281
<211> 3531
<212> DNA
<213> Rattus norvegicus
<308> U25746
<400> 8281

cacgctctg  tggcggtca  tgctggagc  ttggccatt  cgtagggcc  gtcctcgct  60
ggtactgtg  ggacttggt  cctccctcc  ttgtcctct  caccggtct  cgcatcgtc  120
ccaagggcg  aggccttcc  ctggctggc  gcatgggca  ggagtctcg  cattaccga  180
aacggtcag  atctcgagg  cgctctgga  gtcggtcta  gagtcgctc  ccctctgac  240
aaagaagca  acgtggaga  gacaggcgt  ccaggagta  agacagaga  agaaggaga  300
agaggtctc  gagcaggga  aaaaggaga  ctcggtcac  ggacaggaa  cgcctgaga  360
gttccagaa  tagagagcg  gacagaagc  gagagcgaa  aagatctcg  agccgggat  420
gaaggcgct  aaggagtcg  agccggggc  ggcggtccc  gtcttccag  cctggcagc  480
aaagcaaga  ggctgagaa  aggtctagg  ccaaagaga  agcagaagg  ggggacagc  540
ccaaggaga  gaagaaaga  aaggacgac  aggaggacg  gaaagagaa  gatgctggg  600
attttgacc  gaataagct  gaagaagaa  tgagaaaac  aaaagaaag  gttgaaaaa  660
ggcgagaag  gcagcgtaa  aaggcgatg  agaacatag  ggagctgaa  aaggagatc  720
aggagatga  gcaggggaa  aagtggagc  tggaagatg  cgacgatga  gaagatgac  780
ctgccgagg  tgagaagga  gggaatgaa  tggaggacg  ggagctgga  ccattagat  840
cctacatgg  ggaagtgaa  gaagaggta  aaaagttta  catgaggag  gtgaaaggc  900
gcgcaggaa  tgagaagaa  tccggaccg  ctgtcacga  agtggttac  gtggtaaca  960
ccaagaaag  agtagtaga  gccgacaag  agaagggag  gctgatgga  aatgaccag  1020
acgccatgg  gtactcctc  gaggaggaa  aggttgacc  tcagacggc  ctcacaggc  1080
accagacaa  acagagaaa  cttctagag  cagtggatc  tgggaaaat  gagtatgag  1140
cattcagaa  aaactttta  gttgaagtt  cagaattag  gaaaatgtc  caagaagag  1200
tgaatgtgt  tcggttgga  atggagggc  ttacagtta  aggaaaagg  tgccccaag  1260
caattaaat  atgggtcca  tgtggaatt  ccatgaaga  actgaattc  ctcaaaaag  1320
atggctatg  aaagcccac  ccaatccaa  ctcaagcaa  tcctgctat  atgtctgga  1380
gagatttga  tggcattgc  aagacagga  gtggaaaaa  cattgcttt  cttttgccc  1440
tgtttagac  catcatgga  cagaggtca  tggaagaag  agagggacc  atcgctgtc  1500
tcatgactc  aactcgaga  ctggcttta  aaatcacta  agaatgtaa  aagttttcg  1560
agaccttgg  actgagagt  gtctgtgtg  atggaggga  aggaatcag  gagcagatt  1620
ctgagctga  gagaggcgc  gagatcatt  tttgcacac  tggccggat  atcgacatg  1680
tggcagcta  cagtggtcg  gtcacaaat  ttcgaagag  gacatatgt  gttttagat  1740
aagcagaca  aatgtttga  atgggtttt  aaccacagg  catgcgcat  gtggacaat  1800
tccgtcctg  ccgacagac  gttatgttc  cagctactt  cccaagagc  atggaagcg  1860
tggcccgca  gatcttgag  aagcccatt  aagttcagg  tggaggccg  agtgtggtt  1920
gctcagatg  ggaacaaca  gtgattgtg  ttgaagaag  gaagaaatt  ttgaaattg  1980
tggagcttt  aggccatta  caggagtca  gatctgtca  tatatttgt  gataagcag  2040
aacacgctg  tggtcttct  aaggacttg  tgagagctt  ctacccttg  atgtctctt  2100
acggaggta  tgatcagta  gacagggac  gtatcataa  tgactttaa  aatggaacc  2160
gcaaacttc  cgtagccac  tctgttgcc  cccgtggtc  agatgtgaa  catctcatt  2220
ttgtagtaa  ttacagctg  cccaatcat  acgaagatt  cgtgcacag  gctgggcgg  2280
ctggaagag  aggcaacaa  ggttatgcc  acaccttca  cacagaaga  caagctcga  2340
atgctgggg  catcattaa  gctcttgaa  tgtcgggga  ggcggtgcc  cctgaccta  2400
agaaactat  gagtgactt  aaagatcag  agaaagctg  aggaaaaat  attaaaaag  2460
gcagcggct  ctctggcaa  gggttcaag  ttgatgaga  agagcaggc  ttagccaat  2520
agaggaaaa  gctacaaaa  gctgccctt  gcctgcagg  ttctgatga  gaggacgcc  2580
cagttgata  tgacgagca  attgaaagc  tgtttaatt  caagaagag  gtgaaagac  2640
tggctgctc  cggcacatc  agtgcgcct  ctccgactg  gggcaatgc  gagaagcta  2700
agattgcca  gaggttggc  cttagaatc  acgctcaga  gaacctggg  atcgagtct  2760
aggtagatg  gatgcagca  gccacaaat  ccatcctca  aggtggccc  cttctggct  2820
ccaccgtgt  tgcaaaaac  atcgcagag  agcttgccg  gaagatcaa  gccaagctc  2880
attacgtgc  tttggagaa  caggaagaa  agagacagg  gggtgggca  agcgaatct  2940
tcaagagat  cgaggaaga  ttagaaatt  atgacttcc  acagacggc  aggtggaaa  3000
ttacctcta  ggaagcctt  cagaggatc  gtgagtact  ggaagccgc  atcacaatc  3060
gagggacct  cttcccgcc  ggcaaagag  ccaaggaag  agagcggaa  atctacttg  3120
cgattgaaa  tgccaacga  ctggctgtg  agaaagcaa  ggcagagat  accaggctc  3180
taaaagagg  gctgatccg  ctgcaaaat  cataccaac  caccaacaa  ggacgatac  3240
aagtattat  aacaccgga  ccactttgt  cccgtgcta  ctgtgacgt  tacagtgta  3300
tgtaaagta  gacttttaa  attctgtct  gcttatttt  taagtacaa  aaaccagtg  3360
ttgttcaag  ggtcatctg  aagtactac  ctataccca  ccaaactcc  tttaaatca  3420
agctgtttt  agagtgtga  gttcttcga  gtaaacctt  gataccaac  ctttaaata  3480
ctggagaca  tgggatttt  tactgaatg  agtaataaa  tgtgtcagg  a  3531



<210> 8282
<211> 1033
<212> PRT
<213> Rattus norvegicus
<308> U25746
<400> 8282

Met Gly Arg Glu Ser Arg His Tyr Arg Lys Arg Ser Ala Ser Arg Gly 
  1               5                  10                  15
Arg Ser Gly Ser Arg Ser Arg Ser Arg Ser Pro Ser Asp Lys Arg Ser 
             20                  25                  30
Lys Arg Gly Asp Asp Arg Arg Ser Arg Ser Arg Asp Arg Asp Arg Arg 
         35                  40                  45
Arg Glu Arg Ser Arg Ser Arg Asp Lys Arg Arg Ser Arg Ser Arg Asp 
     50                  55                  60
Arg Lys Arg Leu Arg Arg Ser Arg Ser Arg Glu Arg Asp Arg Ser Arg 
 65                  70                  75                  80
Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser Arg 
                 85                  90                  95
Ser Arg Gly Arg Arg Ser Arg Ser Ser Ser Pro Gly Ser Lys Ser Lys 
             100                105                110
Lys Ala Glu Asn Arg Ser Arg Ser Lys Glu Lys Ala Glu Gly Gly Asp 
         115                120                125
Ser Ser Lys Glu Lys Lys Lys Asp Lys Asp Asp Lys Glu Asp Glu Lys 
     130                135                140
Glu Lys Asp Ala Gly Asn Phe Asp Gln Asn Lys Leu Glu Glu Glu Met 
 145                150                155                160
Arg Lys Arg Lys Glu Arg Val Glu Lys Trp Arg Glu Glu Gln Arg Lys 
                 165                170                175
Lys Ala Met Glu Asn Ile Gly Glu Leu Lys Lys Glu Ile Glu Glu Met 
             180                185                190
Lys Gln Gly Lys Lys Trp Ser Leu Glu Asp Asp Asp Asp Asp Glu Asp 
         195                200                205
Asp Pro Ala Glu Ala Glu Lys Glu Gly Asn Glu Met Glu Asp Glu Glu 
     210                215                220
Leu Asp Pro Leu Asp Ala Tyr Met Glu Glu Val Lys Glu Glu Val Lys 
 225                230                235                240
Lys Phe Asn Met Arg Ser Val Lys Gly Gly Ala Gly Asn Glu Lys Lys 
                 245                250                255
Ser Gly Pro Thr Val Thr Lys Val Val Thr Val Val Thr Thr Lys Lys 
             260                265                270
Ala Val Val Asp Ala Asp Lys Lys Lys Gly Glu Leu Met Glu Asn Asp 
         275                280                285
Gln Asp Ala Met Glu Tyr Ser Ser Glu Glu Glu Glu Val Asp Leu Gln 
     290                295                300
Thr Ala Leu Thr Gly Tyr Gln Thr Lys Gln Arg Lys Leu Leu Glu Pro 
 305                310                315                320
Val Asp His Gly Lys Ile Glu Tyr Glu Pro Phe Arg Lys Asn Phe Tyr 
                 325                330                335
Val Glu Val Pro Glu Leu Ala Lys Met Ser Gln Glu Glu Val Asn Val 
             340                345                350
Phe Arg Leu Glu Met Glu Gly Ile Thr Val Lys Gly Lys Gly Cys Pro 
         355                360                365
Lys Pro Ile Lys Ser Trp Val Gln Cys Gly Ile Ser Met Lys Ile Leu 
     370                375                380
Asn Ser Leu Lys Lys His Gly Tyr Glu Lys Pro Thr Pro Ile Gln Thr 
 385                390                395                400
Gln Ala Ile Pro Ala Ile Met Ser Gly Arg Asp Leu Ile Gly Ile Ala 
                 405                410                415
Lys Thr Gly Ser Gly Lys Thr Ile Ala Phe Leu Leu Pro Met Phe Arg 
             420                425                430
His Ile Met Asp Gln Arg Ser Leu Glu Glu Gly Glu Gly Pro Ile Ala 
         435                440                445
Val Ile Met Thr Pro Thr Arg Glu Leu Ala Leu Gln Ile Thr Lys Glu 
     450                455                460
Cys Lys Lys Phe Ser Lys Thr Leu Gly Leu Arg Val Val Cys Val Tyr 
 465                470                475                480
Gly Gly Thr Gly Ile Ser Glu Gln Ile Ala Glu Leu Lys Arg Gly Ala 
                 485                490                495
Glu Ile Ile Val Cys Thr Pro Gly Arg Met Ile Asp Met Leu Ala Ala 
             500                505                510
Asn Ser Gly Arg Val Thr Asn Leu Arg Arg Val Thr Tyr Val Val Leu 
         515                520                525
Asp Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Pro Gln Val Met 
     530                535                540
Arg Ile Val Asp Asn Val Arg Pro Asp Arg Gln Thr Val Met Phe Ser 
 545                550                555                560
Ala Thr Phe Pro Arg Ala Met Glu Ala Leu Ala Arg Arg Ile Leu Ser 
                 565                570                575
Lys Pro Ile Glu Val Gln Val Gly Gly Arg Ser Val Val Cys Ser Asp 
             580                585                590
Val Glu Gln Gln Val Ile Val Ile Glu Glu Glu Lys Lys Phe Leu Lys 
         595                600                605
Leu Leu Glu Leu Leu Gly His Tyr Gln Glu Ser Gly Ser Val Ile Ile 
     610                615                620
Phe Val Asp Lys Gln Glu His Ala Asp Gly Leu Leu Lys Asp Leu Met 
 625                630                635                640
Arg Ala Ser Tyr Pro Cys Met Ser Leu His Gly Gly Ile Asp Gln Tyr 
                 645                650                655
Asp Arg Asp Ser Ile Ile Asn Asp Phe Lys Asn Gly Thr Cys Lys Leu 
             660                665                670
Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Val Lys His Leu 
         675                680                685
Ile Leu Val Val Asn Tyr Ser Cys Pro Asn His Tyr Glu Asp Tyr Val 
     690                695                700
His Arg Ala Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Tyr Ala Tyr 
 705                710                715                720
Thr Phe Ile Thr Glu Asp Gln Ala Arg Tyr Ala Gly Asp Ile Ile Lys 
                 725                730                735
Ala Leu Glu Leu Ser Gly Thr Ala Val Pro Pro Asp Leu Glu Lys Leu 
             740                745                750
Trp Ser Asp Phe Lys Asp Gln Gln Lys Ala Glu Gly Lys Ile Ile Lys 
         755                760                765
Lys Ser Ser Gly Phe Ser Gly Lys Gly Phe Lys Phe Asp Glu Thr Glu 
     770                775                780
Gln Ala Leu Ala Asn Glu Arg Lys Lys Leu Gln Lys Ala Ala Leu Gly 
 785                790                795                800
Leu Gln Asp Ser Asp Asp Glu Asp Ala Ala Val Asp Ile Asp Glu Gln 
                 805                810                815
Ile Glu Ser Met Phe Asn Ser Lys Lys Arg Val Lys Asp Met Ala Ala 
             820                825                830
Pro Gly Thr Ser Ser Ala Pro Ala Pro Thr Ala Gly Asn Ala Glu Lys 
         835                840                845
Leu Glu Ile Ala Lys Arg Leu Ala Leu Arg Ile Asn Ala Gln Lys Asn 
     850                855                860
Leu Gly Ile Glu Ser Gln Val Asp Val Met Gln Gln Ala Thr Asn Ala 
 865                870                875                880
Ile Leu Arg Gly Gly Pro Leu Leu Ala Pro Thr Val Ser Ala Lys Thr 
                 885                890                895
Ile Ala Glu Gln Leu Ala Glu Lys Ile Asn Ala Lys Leu Asn Tyr Val 
             900                905                910
Pro Leu Glu Lys Gln Glu Glu Glu Arg Gln Glu Gly Gly Gln Ser Glu 
         915                920                925
Ser Phe Lys Arg Tyr Glu Glu Glu Leu Glu Ile Asn Asp Phe Pro Gln 
     930                935                940
Thr Ala Arg Trp Lys Val Thr Ser Lys Glu Ala Leu Gln Arg Ile Ser 
 945                950                955                960
Glu Tyr Ser Glu Ala Ala Ile Thr Ile Arg Gly Thr Tyr Phe Pro Pro 
                 965                970                975
Gly Lys Glu Pro Lys Glu Gly Glu Arg Lys Ile Tyr Leu Ala Ile Glu 
             980                985                990
Ser Ala Asn Glu Leu Ala Val Gln Lys Ala Lys Ala Glu Ile Thr Arg 
         995                1000                1005
Leu Ile Lys Glu Glu Leu Ile Arg Leu Gln Asn Ser Tyr Gln Pro Thr 
     1010                1015                1020
Asn Lys Gly Arg Tyr Lys Val Leu Ter 
 1025                1030



<210> 8283
<211> 3746
<212> DNA
<213> Homo sapiens
<308> AF106680
<400> 8283

cccgcgctg  gatggccgc  acagctgta  gtgctgcta  tgtttagcg  tggtctttg  60
cgggcgttg  gggcagctc  gcctccttg  ttgtccggt  cgcctgtgc  tggtactca  120
gggcaccag  attcccgcg  tcggcagca  gggtcggga  tcacgccac  atcgaaaac  180
atcggcatc  cggggtcgc  ctggaagtc  gtctagaag  cgctcaccc  cagacaaaa  240
aagtaaacg  ggagatgac  gacggtcta  aagtagaga  agagatagg  ggagagaga  300
gtctcgtag  agggataaa  gaagatctc  gtcaaggga  aggaagcgt  tgagacgtt  360
cagaagtag  gagagagac  gaagccgag  gcgaagaag  tctcgaagt  gagacagga  420
acgctcaag  agtagaagc  ggggccggc  atcccgatc  tccagtcct  gcagcaaaa  480
caagaaggc  gagaacagg  ctaggtcca  agagaaagc  gaaggtggg  acagctcca  540
ggagaagaa  aaagacaag  acgacaagg  ggacgagaa  gagaaggat  ctgggaatt  600
tgaccagaa  aagctggaa  aagaaatga  aaaacgaaa  gaaagggtt  aaaaatggc  660
agaagagca  cgtaaaaag  cgatggaga  catagggga  ctgaagaag  agatcgagg  720
gatgaagca  gggaagaag  ggagcctgg  agatgacga  gatgatgaa  atgaccctg  780
cgaggctga  aaggaaggg  atgaaatgg  ggacgagga  ctggaccca  tagatgcct  840
catggagga  gtgaaagaa  aggtaaaaa  gtttaacat  aggagcgtg  aaggcggcg  900
aggaaatga  aagaagtcc  ggccaacgg  cacaaaagt  gtcactgtt  tgacaacca  960
aaaagcagt  gtggattct  ataagaaga  aggtgagct  atggagaat  accaggatg  1020
catggagta  tcttcagag  aggaagaag  tgatcttca  acagccctt  cagggtatc  1080
aacaaaaca  cgaaaactt  tagaaccag  tgatcatgg  aaaattgag  atgagccat  1140
taggaaaaa  ttctatgtt  aagttccag  actagcaaa  atgtctcaa  aagaggtaa  1200
tgtgtttcg  ttggaaatg  agggcatta  agttaaagg  aaaggttgc  ccaaaccaa  1260
taaatcctg  gtccagtgt  gaatttcca  gaagatctt  aattccctc  agaagcatg  1320
ctatgaaaa  cccacgccc  tccaaaccc  agctattcc  gctataatg  ctggacgag  1380
tttgattgg  attgccaaa  caggaagtg  aaagaccat  gcttttctg  tgcccatgt  1440
tagacacat  atggatcag  ggtcattag  ggaaggaga  gggccatta  ctgtcatca  1500
gactcccac  cgagaactg  ctttacaga  acctaaggg  gtaagaagt  tcaagactt  1560
gggacttag  gtggtctgt  tttacggag  aacaggaat  agtgagcag  ttgctgagc  1620
gaaaagagg  gctgaaatt  ttgtttgca  acctggtcg  atgattgac  tgttagccg  1680
taacagtgg  cgggtcaca  atcttcgaa  agtgacata  gttgtttta  atgaagcag  1740
cagaatgtt  gacatgggt  ttgaacccc  ggtcatgcg  atcgtggat  atgttcgtc  1800
tgatcgaca  acggttatg  tttcagcta  tttcccaag  gctatggaa  cgttggccc  1860
caggatctt  agcaagccc  ttgaagttc  ggttggagg  cggagtgtg  tttgctcag  1920
tgtggaaca  caagtgatt  tgattgaag  agagaagaa  ttcttgaaa  tgctggagc  1980
tttaggcca  tatcaggag  caggatctg  cattatatt  gtggataag  aggaacacg  2040
tgatggtct  ctgaaggat  taatgagag  atcttatcc  tgcatgtct  ttcatggag  2100
cattgatca  tatgacaga  atagcatca  aaatgactt  aagaatggg  cctgcaaac  2160
tcttgtggc  acctctgtt  ctgcccgag  tctagatgt  aaacatctg  ttcttgtag  2220
aaattatag  tgccccaac  attatgagg  ttatgtaca  agagcaggg  ggactggaa  2280
agcaggaaa  aagggttat  cttatactt  tatcacaga  gatcaagct  gctatgctg  2340
tgacataat  aaagctctt  aattgtcgg  gactgcggt  cctcctgac  tagagaaac  2400
atggagtga  ttcaaagat  agcagaaag  tgaaggaaa  ataattaaa  agagcagcg  2460
cttctctgg  aaggggttc  agtttgatg  gacagagca  gctttagcc  atgagagga  2520
aaagctaca  aaagctgcc  ttggcctgc  agattcaga  gatgaggat  ctgcagttg  2580
tattgatga  caaattgaa  gcatgttta  ttcaaagaa  agagtaaag  atatggctg  2640
tcctggaac  tcaagtgtt  ctgctccaa  tgcaggaaa  gctgagaaa  tagaaattg  2700
taagagatt  gctcttaga  tcaatgccc  gaagaattt  ggcatcgag  ctcaggtag  2760
tgtgatgca  caggccacc  atgcaattc  taggggtgg  accattctg  ctcccactg  2820
ttctgcaaa  accattgca  aacaacttg  tgaaaagat  aatgccaag  tcaattatg  2880
gccgttaga  aaacaagaa  aagagagac  ggatggtgg  cagaatgaa  cttttaaga  2940
atatgaaga  gaattagag  tcaatgact  cccacagac  gctaggtgg  aagttacct  3000
taaggaagc  ctgcagaga  tcagtgaat  ctctgaagc  gcaattaca  tcagaggaa  3060
ctacttccc  cctggcaaa  aacccaagg  aggcgagcg  aagatttac  tggcaattg  3120
aagtgccaa  gaactggct  tgcagaaag  aaaggcaga  atcaccagg  tcataaaag  3180
agagctgat  cggctgcaa  attcatacc  accaacaaa  aaaggaaga  acaaagtct  3240
atagacatc  ggaaaaaag  tttttacct  tgctggtct  tgatgtatg  ggcagttgc  3300
gtctgcagt  tacaatgta  tgtaaatga  gatttttta  attctatct  gctgatttt  3360
tttaaatat  agaaactgg  acttggtaa  gaaatctgt  cgtaagtac  cccacaatc  3420
gtcaaacta  atttaaagc  agcctgttt  cagagtatg  tgtccttta  tgtaaactc  3480
aatatcaat  ttttaaatg  ccggataat  ttctagagg  ttaaaaaat  gaaatattt  3540
aactttcta  tgaagacaa  aaagtacac  agtcgttaa  gggctattc  ctttatcct  3600
tactttcaa  gaaattgtg  tcatttcct  agaaaaggt  aaattcact  tcatatttt  3660
tgtccccac  ttgatgtta  atgactctg  aacaatatg  actggattt  agaatgtta  3720
aatagaagt  ttacaaaat  gaaaaa  3746



<210> 8284
<211> 1032
<212> PRT
<213> Homo sapiens
<308> BAA34521
<400> 8284

Met Gly Arg Glu Ser Arg His Tyr Arg Lys Arg Ser Ala Ser Arg Gly 
  1               5                  10                  15
Arg Ser Gly Ser Arg Ser Arg Ser Arg Ser Pro Ser Asp Lys Arg Ser 
             20                  25                  30
Lys Arg Gly Asp Asp Arg Arg Ser Arg Ser Arg Asp Arg Asp Arg Arg 
         35                  40                  45
Arg Glu Arg Ser Arg Ser Arg Asp Lys Arg Arg Ser Arg Ser Arg Asp 
     50                  55                  60
Arg Lys Arg Leu Arg Arg Ser Arg Ser Arg Glu Arg Asp Arg Ser Arg 
 65                  70                  75                  80
Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser Arg 
                 85                  90                  95
Ser Arg Gly Arg Arg Ser Arg Ser Ser Ser Pro Gly Asn Lys Ser Lys 
             100                105                110
Lys Thr Glu Asn Arg Ser Arg Ser Lys Glu Lys Thr Asp Gly Gly Glu 
         115                120                125
Ser Ser Lys Glu Lys Lys Lys Asp Lys Asp Asp Lys Glu Asp Glu Lys 
     130                135                140
Glu Lys Asp Ala Gly Asn Phe Asp Gln Asn Lys Leu Glu Glu Glu Met 
 145                150                155                160
Arg Lys Arg Lys Glu Arg Val Glu Lys Trp Arg Glu Glu Gln Arg Lys 
                 165                170                175
Lys Ala Met Glu Asn Ile Gly Glu Leu Lys Lys Glu Ile Glu Glu Met 
             180                185                190
Lys Gln Gly Lys Lys Trp Ser Leu Glu Asp Asp Asp Asp Asp Glu Asp 
         195                200                205
Asp Pro Ala Glu Ala Glu Lys Glu Gly Asn Glu Met Glu Gly Glu Glu 
     210                215                220
Leu Asp Pro Leu Asp Ala Tyr Met Glu Glu Val Lys Glu Glu Val Lys 
 225                230                235                240
Lys Phe Asn Met Arg Ser Val Lys Gly Gly Gly Gly Asn Glu Lys Lys 
                 245                250                255
Ser Gly Pro Thr Val Thr Lys Val Val Thr Val Val Thr Thr Lys Lys 
             260                265                270
Ala Val Val Asp Ser Asp Lys Lys Lys Gly Glu Leu Met Glu Asn Asp 
         275                280                285
Gln Asp Ala Met Glu Tyr Ser Ser Glu Glu Glu Glu Val Asp Leu Gln 
     290                295                300
Thr Ala Leu Thr Gly Tyr Gln Thr Lys Gln Arg Lys Leu Leu Glu Pro 
 305                310                315                320
Val Asp His Gly Lys Ile Glu Tyr Glu Pro Phe Arg Lys Asn Phe Tyr 
                 325                330                335
Val Glu Val Pro Glu Leu Ala Lys Met Ser Gln Glu Glu Val Asn Val 
             340                345                350
Phe Arg Leu Glu Met Glu Gly Ile Thr Val Lys Gly Lys Gly Cys Pro 
         355                360                365
Lys Pro Ile Lys Ser Trp Val Gln Cys Gly Ile Ser Met Lys Ile Leu 
     370                375                380
Asn Ser Leu Lys Lys His Gly Tyr Glu Lys Pro Thr Pro Ile Gln Thr 
 385                390                395                400
Gln Ala Ile Pro Ala Ile Met Ser Gly Arg Asp Leu Ile Gly Ile Ala 
                 405                410                415
Lys Thr Gly Ser Gly Lys Thr Ile Ala Phe Leu Leu Pro Met Phe Arg 
             420                425                430
His Ile Met Asp Gln Arg Ser Leu Glu Glu Gly Glu Gly Pro Ile Ala 
         435                440                445
Val Ile Met Thr Pro Thr Arg Glu Leu Ala Leu Gln Ile Thr Lys Glu 
     450                455                460
Cys Lys Lys Phe Ser Lys Thr Leu Gly Leu Arg Val Val Cys Val Tyr 
 465                470                475                480
Gly Gly Thr Gly Ile Ser Glu Gln Ile Ala Glu Leu Lys Arg Gly Ala 
                 485                490                495
Glu Ile Ile Val Cys Thr Pro Gly Arg Met Ile Asp Met Leu Ala Ala 
             500                505                510
Asn Ser Gly Arg Val Thr Asn Leu Arg Arg Val Thr Tyr Val Val Leu 
         515                520                525
Asp Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Pro Gln Val Met 
     530                535                540
Arg Ile Val Asp Asn Val Arg Pro Asp Arg Gln Thr Val Met Phe Ser 
 545                550                555                560
Ala Thr Phe Pro Arg Ala Met Glu Ala Leu Ala Arg Arg Ile Leu Ser 
                 565                570                575
Lys Pro Ile Glu Val Gln Val Gly Gly Arg Ser Val Val Cys Ser Asp 
             580                585                590
Val Glu Gln Gln Val Ile Val Ile Glu Glu Glu Lys Lys Phe Leu Lys 
         595                600                605
Leu Leu Glu Leu Leu Gly His Tyr Gln Glu Ser Gly Ser Val Ile Ile 
     610                615                620
Phe Val Asp Lys Gln Glu His Ala Asp Gly Leu Leu Lys Asp Leu Met 
 625                630                635                640
Arg Ala Ser Tyr Pro Cys Met Ser Leu His Gly Gly Ile Asp Gln Tyr 
                 645                650                655
Asp Arg Asp Ser Ile Ile Asn Asp Phe Lys Asn Gly Thr Cys Lys Leu 
             660                665                670
Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Val Lys His Leu 
         675                680                685
Ile Leu Val Val Asn Tyr Ser Cys Pro Asn His Tyr Glu Asp Tyr Val 
     690                695                700
His Arg Ala Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Tyr Ala Tyr 
 705                710                715                720
Thr Phe Ile Thr Glu Asp Gln Ala Arg Tyr Ala Gly Asp Ile Ile Lys 
                 725                730                735
Ala Leu Glu Leu Ser Gly Thr Ala Val Pro Pro Asp Leu Glu Lys Leu 
             740                745                750
Trp Ser Asp Phe Lys Asp Gln Gln Lys Ala Glu Gly Lys Ile Ile Lys 
         755                760                765
Lys Ser Ser Gly Phe Ser Gly Lys Gly Phe Lys Phe Asp Glu Thr Glu 
     770                775                780
Gln Ala Leu Ala Asn Glu Arg Lys Lys Leu Gln Lys Ala Ala Leu Gly 
 785                790                795                800
Leu Gln Asp Ser Asp Asp Glu Asp Ala Ala Val Asp Ile Asp Glu Gln 
                 805                810                815
Ile Glu Ser Met Phe Asn Ser Lys Lys Arg Val Lys Asp Met Ala Ala 
             820                825                830
Pro Gly Thr Ser Ser Val Pro Ala Pro Thr Ala Gly Asn Ala Glu Lys 
         835                840                845
Leu Glu Ile Ala Lys Arg Leu Ala Leu Arg Ile Asn Ala Gln Lys Asn 
     850                855                860
Leu Gly Ile Glu Ser Gln Val Asp Val Met Gln Gln Ala Thr Asn Ala 
 865                870                875                880
Ile Leu Arg Gly Gly Thr Ile Leu Ala Pro Thr Val Ser Ala Lys Thr 
                 885                890                895
Ile Ala Glu Gln Leu Ala Glu Lys Ile Asn Ala Lys Leu Asn Tyr Val 
             900                905                910
Pro Leu Glu Lys Gln Glu Glu Glu Arg Gln Asp Gly Gly Gln Asn Glu 
         915                920                925
Ser Phe Lys Arg Tyr Glu Glu Glu Leu Glu Ile Asn Asp Phe Pro Gln 
     930                935                940
Thr Ala Arg Trp Lys Val Thr Ser Lys Glu Ala Leu Gln Arg Ile Ser 
 945                950                955                960
Glu Tyr Ser Glu Ala Ala Ile Thr Ile Arg Gly Thr Tyr Phe Pro Pro 
                 965                970                975
Gly Lys Glu Pro Lys Glu Gly Glu Arg Lys Ile Tyr Leu Ala Ile Glu 
             980                985                990
Ser Ala Asn Glu Leu Ala Val Gln Lys Ala Lys Ala Glu Ile Thr Arg 
         995                1000                1005
Leu Ile Lys Glu Glu Leu Ile Arg Leu Gln Asn Ser Tyr Gln Pro Thr 
     1010                1015                1020
Asn Lys Gly Arg Tyr Lys Val Leu 
 1025                1030



<210> 8285
<211> 3531
<212> DNA
<213> Rattus norvegicus
<308> U25746
<400> 8285

cacgctctg  tggcggtca  tgctggagc  ttggccatt  cgtagggcc  gtcctcgct  60
ggtactgtg  ggacttggt  cctccctcc  ttgtcctct  caccggtct  cgcatcgtc  120
ccaagggcg  aggccttcc  ctggctggc  gcatgggca  ggagtctcg  cattaccga  180
aacggtcag  atctcgagg  cgctctgga  gtcggtcta  gagtcgctc  ccctctgac  240
aaagaagca  acgtggaga  gacaggcgt  ccaggagta  agacagaga  agaaggaga  300
agaggtctc  gagcaggga  aaaaggaga  ctcggtcac  ggacaggaa  cgcctgaga  360
gttccagaa  tagagagcg  gacagaagc  gagagcgaa  aagatctcg  agccgggat  420
gaaggcgct  aaggagtcg  agccggggc  ggcggtccc  gtcttccag  cctggcagc  480
aaagcaaga  ggctgagaa  aggtctagg  ccaaagaga  agcagaagg  ggggacagc  540
ccaaggaga  gaagaaaga  aaggacgac  aggaggacg  gaaagagaa  gatgctggg  600
attttgacc  gaataagct  gaagaagaa  tgagaaaac  aaaagaaag  gttgaaaaa  660
ggcgagaag  gcagcgtaa  aaggcgatg  agaacatag  ggagctgaa  aaggagatc  720
aggagatga  gcaggggaa  aagtggagc  tggaagatg  cgacgatga  gaagatgac  780
ctgccgagg  tgagaagga  gggaatgaa  tggaggacg  ggagctgga  ccattagat  840
cctacatgg  ggaagtgaa  gaagaggta  aaaagttta  catgaggag  gtgaaaggc  900
gcgcaggaa  tgagaagaa  tccggaccg  ctgtcacga  agtggttac  gtggtaaca  960
ccaagaaag  agtagtaga  gccgacaag  agaagggag  gctgatgga  aatgaccag  1020
acgccatgg  gtactcctc  gaggaggaa  aggttgacc  tcagacggc  ctcacaggc  1080
accagacaa  acagagaaa  cttctagag  cagtggatc  tgggaaaat  gagtatgag  1140
cattcagaa  aaactttta  gttgaagtt  cagaattag  gaaaatgtc  caagaagag  1200
tgaatgtgt  tcggttgga  atggagggc  ttacagtta  aggaaaagg  tgccccaag  1260
caattaaat  atgggtcca  tgtggaatt  ccatgaaga  actgaattc  ctcaaaaag  1320
atggctatg  aaagcccac  ccaatccaa  ctcaagcaa  tcctgctat  atgtctgga  1380
gagatttga  tggcattgc  aagacagga  gtggaaaaa  cattgcttt  cttttgccc  1440
tgtttagac  catcatgga  cagaggtca  tggaagaag  agagggacc  atcgctgtc  1500
tcatgactc  aactcgaga  ctggcttta  aaatcacta  agaatgtaa  aagttttcg  1560
agaccttgg  actgagagt  gtctgtgtg  atggaggga  aggaatcag  gagcagatt  1620
ctgagctga  gagaggcgc  gagatcatt  tttgcacac  tggccggat  atcgacatg  1680
tggcagcta  cagtggtcg  gtcacaaat  ttcgaagag  gacatatgt  gttttagat  1740
aagcagaca  aatgtttga  atgggtttt  aaccacagg  catgcgcat  gtggacaat  1800
tccgtcctg  ccgacagac  gttatgttc  cagctactt  cccaagagc  atggaagcg  1860
tggcccgca  gatcttgag  aagcccatt  aagttcagg  tggaggccg  agtgtggtt  1920
gctcagatg  ggaacaaca  gtgattgtg  ttgaagaag  gaagaaatt  ttgaaattg  1980
tggagcttt  aggccatta  caggagtca  gatctgtca  tatatttgt  gataagcag  2040
aacacgctg  tggtcttct  aaggacttg  tgagagctt  ctacccttg  atgtctctt  2100
acggaggta  tgatcagta  gacagggac  gtatcataa  tgactttaa  aatggaacc  2160
gcaaacttc  cgtagccac  tctgttgcc  cccgtggtc  agatgtgaa  catctcatt  2220
ttgtagtaa  ttacagctg  cccaatcat  acgaagatt  cgtgcacag  gctgggcgg  2280
ctggaagag  aggcaacaa  ggttatgcc  acaccttca  cacagaaga  caagctcga  2340
atgctgggg  catcattaa  gctcttgaa  tgtcgggga  ggcggtgcc  cctgaccta  2400
agaaactat  gagtgactt  aaagatcag  agaaagctg  aggaaaaat  attaaaaag  2460
gcagcggct  ctctggcaa  gggttcaag  ttgatgaga  agagcaggc  ttagccaat  2520
agaggaaaa  gctacaaaa  gctgccctt  gcctgcagg  ttctgatga  gaggacgcc  2580
cagttgata  tgacgagca  attgaaagc  tgtttaatt  caagaagag  gtgaaagac  2640
tggctgctc  cggcacatc  agtgcgcct  ctccgactg  gggcaatgc  gagaagcta  2700
agattgcca  gaggttggc  cttagaatc  acgctcaga  gaacctggg  atcgagtct  2760
aggtagatg  gatgcagca  gccacaaat  ccatcctca  aggtggccc  cttctggct  2820
ccaccgtgt  tgcaaaaac  atcgcagag  agcttgccg  gaagatcaa  gccaagctc  2880
attacgtgc  tttggagaa  caggaagaa  agagacagg  gggtgggca  agcgaatct  2940
tcaagagat  cgaggaaga  ttagaaatt  atgacttcc  acagacggc  aggtggaaa  3000
ttacctcta  ggaagcctt  cagaggatc  gtgagtact  ggaagccgc  atcacaatc  3060
gagggacct  cttcccgcc  ggcaaagag  ccaaggaag  agagcggaa  atctacttg  3120
cgattgaaa  tgccaacga  ctggctgtg  agaaagcaa  ggcagagat  accaggctc  3180
taaaagagg  gctgatccg  ctgcaaaat  cataccaac  caccaacaa  ggacgatac  3240
aagtattat  aacaccgga  ccactttgt  cccgtgcta  ctgtgacgt  tacagtgta  3300
tgtaaagta  gacttttaa  attctgtct  gcttatttt  taagtacaa  aaaccagtg  3360
ttgttcaag  ggtcatctg  aagtactac  ctataccca  ccaaactcc  tttaaatca  3420
agctgtttt  agagtgtga  gttcttcga  gtaaacctt  gataccaac  ctttaaata  3480
ctggagaca  tgggatttt  tactgaatg  agtaataaa  tgtgtcagg  a  3531



<210> 8286
<211> 1033
<212> PRT
<213> Rattus norvegicus
<308> U25746
<400> 8286

Met Gly Arg Glu Ser Arg His Tyr Arg Lys Arg Ser Ala Ser Arg Gly 
  1               5                  10                  15
Arg Ser Gly Ser Arg Ser Arg Ser Arg Ser Pro Ser Asp Lys Arg Ser 
             20                  25                  30
Lys Arg Gly Asp Asp Arg Arg Ser Arg Ser Arg Asp Arg Asp Arg Arg 
         35                  40                  45
Arg Glu Arg Ser Arg Ser Arg Asp Lys Arg Arg Ser Arg Ser Arg Asp 
     50                  55                  60
Arg Lys Arg Leu Arg Arg Ser Arg Ser Arg Glu Arg Asp Arg Ser Arg 
 65                  70                  75                  80
Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser Arg 
                 85                  90                  95
Ser Arg Gly Arg Arg Ser Arg Ser Ser Ser Pro Gly Ser Lys Ser Lys 
             100                105                110
Lys Ala Glu Asn Arg Ser Arg Ser Lys Glu Lys Ala Glu Gly Gly Asp 
         115                120                125
Ser Ser Lys Glu Lys Lys Lys Asp Lys Asp Asp Lys Glu Asp Glu Lys 
     130                135                140
Glu Lys Asp Ala Gly Asn Phe Asp Gln Asn Lys Leu Glu Glu Glu Met 
 145                150                155                160
Arg Lys Arg Lys Glu Arg Val Glu Lys Trp Arg Glu Glu Gln Arg Lys 
                 165                170                175
Lys Ala Met Glu Asn Ile Gly Glu Leu Lys Lys Glu Ile Glu Glu Met 
             180                185                190
Lys Gln Gly Lys Lys Trp Ser Leu Glu Asp Asp Asp Asp Asp Glu Asp 
         195                200                205
Asp Pro Ala Glu Ala Glu Lys Glu Gly Asn Glu Met Glu Asp Glu Glu 
     210                215                220
Leu Asp Pro Leu Asp Ala Tyr Met Glu Glu Val Lys Glu Glu Val Lys 
 225                230                235                240
Lys Phe Asn Met Arg Ser Val Lys Gly Gly Ala Gly Asn Glu Lys Lys 
                 245                250                255
Ser Gly Pro Thr Val Thr Lys Val Val Thr Val Val Thr Thr Lys Lys 
             260                265                270
Ala Val Val Asp Ala Asp Lys Lys Lys Gly Glu Leu Met Glu Asn Asp 
         275                280                285
Gln Asp Ala Met Glu Tyr Ser Ser Glu Glu Glu Glu Val Asp Leu Gln 
     290                295                300
Thr Ala Leu Thr Gly Tyr Gln Thr Lys Gln Arg Lys Leu Leu Glu Pro 
 305                310                315                320
Val Asp His Gly Lys Ile Glu Tyr Glu Pro Phe Arg Lys Asn Phe Tyr 
                 325                330                335
Val Glu Val Pro Glu Leu Ala Lys Met Ser Gln Glu Glu Val Asn Val 
             340                345                350
Phe Arg Leu Glu Met Glu Gly Ile Thr Val Lys Gly Lys Gly Cys Pro 
         355                360                365
Lys Pro Ile Lys Ser Trp Val Gln Cys Gly Ile Ser Met Lys Ile Leu 
     370                375                380
Asn Ser Leu Lys Lys His Gly Tyr Glu Lys Pro Thr Pro Ile Gln Thr 
 385                390                395                400
Gln Ala Ile Pro Ala Ile Met Ser Gly Arg Asp Leu Ile Gly Ile Ala 
                 405                410                415
Lys Thr Gly Ser Gly Lys Thr Ile Ala Phe Leu Leu Pro Met Phe Arg 
             420                425                430
His Ile Met Asp Gln Arg Ser Leu Glu Glu Gly Glu Gly Pro Ile Ala 
         435                440                445
Val Ile Met Thr Pro Thr Arg Glu Leu Ala Leu Gln Ile Thr Lys Glu 
     450                455                460
Cys Lys Lys Phe Ser Lys Thr Leu Gly Leu Arg Val Val Cys Val Tyr 
 465                470                475                480
Gly Gly Thr Gly Ile Ser Glu Gln Ile Ala Glu Leu Lys Arg Gly Ala 
                 485                490                495
Glu Ile Ile Val Cys Thr Pro Gly Arg Met Ile Asp Met Leu Ala Ala 
             500                505                510
Asn Ser Gly Arg Val Thr Asn Leu Arg Arg Val Thr Tyr Val Val Leu 
         515                520                525
Asp Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Pro Gln Val Met 
     530                535                540
Arg Ile Val Asp Asn Val Arg Pro Asp Arg Gln Thr Val Met Phe Ser 
 545                550                555                560
Ala Thr Phe Pro Arg Ala Met Glu Ala Leu Ala Arg Arg Ile Leu Ser 
                 565                570                575
Lys Pro Ile Glu Val Gln Val Gly Gly Arg Ser Val Val Cys Ser Asp 
             580                585                590
Val Glu Gln Gln Val Ile Val Ile Glu Glu Glu Lys Lys Phe Leu Lys 
         595                600                605
Leu Leu Glu Leu Leu Gly His Tyr Gln Glu Ser Gly Ser Val Ile Ile 
     610                615                620
Phe Val Asp Lys Gln Glu His Ala Asp Gly Leu Leu Lys Asp Leu Met 
 625                630                635                640
Arg Ala Ser Tyr Pro Cys Met Ser Leu His Gly Gly Ile Asp Gln Tyr 
                 645                650                655
Asp Arg Asp Ser Ile Ile Asn Asp Phe Lys Asn Gly Thr Cys Lys Leu 
             660                665                670
Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Val Lys His Leu 
         675                680                685
Ile Leu Val Val Asn Tyr Ser Cys Pro Asn His Tyr Glu Asp Tyr Val 
     690                695                700
His Arg Ala Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Tyr Ala Tyr 
 705                710                715                720
Thr Phe Ile Thr Glu Asp Gln Ala Arg Tyr Ala Gly Asp Ile Ile Lys 
                 725                730                735
Ala Leu Glu Leu Ser Gly Thr Ala Val Pro Pro Asp Leu Glu Lys Leu 
             740                745                750
Trp Ser Asp Phe Lys Asp Gln Gln Lys Ala Glu Gly Lys Ile Ile Lys 
         755                760                765
Lys Ser Ser Gly Phe Ser Gly Lys Gly Phe Lys Phe Asp Glu Thr Glu 
     770                775                780
Gln Ala Leu Ala Asn Glu Arg Lys Lys Leu Gln Lys Ala Ala Leu Gly 
 785                790                795                800
Leu Gln Asp Ser Asp Asp Glu Asp Ala Ala Val Asp Ile Asp Glu Gln 
                 805                810                815
Ile Glu Ser Met Phe Asn Ser Lys Lys Arg Val Lys Asp Met Ala Ala 
             820                825                830
Pro Gly Thr Ser Ser Ala Pro Ala Pro Thr Ala Gly Asn Ala Glu Lys 
         835                840                845
Leu Glu Ile Ala Lys Arg Leu Ala Leu Arg Ile Asn Ala Gln Lys Asn 
     850                855                860
Leu Gly Ile Glu Ser Gln Val Asp Val Met Gln Gln Ala Thr Asn Ala 
 865                870                875                880
Ile Leu Arg Gly Gly Pro Leu Leu Ala Pro Thr Val Ser Ala Lys Thr 
                 885                890                895
Ile Ala Glu Gln Leu Ala Glu Lys Ile Asn Ala Lys Leu Asn Tyr Val 
             900                905                910
Pro Leu Glu Lys Gln Glu Glu Glu Arg Gln Glu Gly Gly Gln Ser Glu 
         915                920                925
Ser Phe Lys Arg Tyr Glu Glu Glu Leu Glu Ile Asn Asp Phe Pro Gln 
     930                935                940
Thr Ala Arg Trp Lys Val Thr Ser Lys Glu Ala Leu Gln Arg Ile Ser 
 945                950                955                960
Glu Tyr Ser Glu Ala Ala Ile Thr Ile Arg Gly Thr Tyr Phe Pro Pro 
                 965                970                975
Gly Lys Glu Pro Lys Glu Gly Glu Arg Lys Ile Tyr Leu Ala Ile Glu 
             980                985                990
Ser Ala Asn Glu Leu Ala Val Gln Lys Ala Lys Ala Glu Ile Thr Arg 
         995                1000                1005
Leu Ile Lys Glu Glu Leu Ile Arg Leu Gln Asn Ser Tyr Gln Pro Thr 
     1010                1015                1020
Asn Lys Gly Arg Tyr Lys Val Leu Ter 
 1025                1030



<210> 8287
<211> 3746
<212> DNA
<213> Homo sapiens
<308> AF106680
<400> 8287

cccgcgctg  gatggccgc  acagctgta  gtgctgcta  tgtttagcg  tggtctttg  60
cgggcgttg  gggcagctc  gcctccttg  ttgtccggt  cgcctgtgc  tggtactca  120
gggcaccag  attcccgcg  tcggcagca  gggtcggga  tcacgccac  atcgaaaac  180
atcggcatc  cggggtcgc  ctggaagtc  gtctagaag  cgctcaccc  cagacaaaa  240
aagtaaacg  ggagatgac  gacggtcta  aagtagaga  agagatagg  ggagagaga  300
gtctcgtag  agggataaa  gaagatctc  gtcaaggga  aggaagcgt  tgagacgtt  360
cagaagtag  gagagagac  gaagccgag  gcgaagaag  tctcgaagt  gagacagga  420
acgctcaag  agtagaagc  ggggccggc  atcccgatc  tccagtcct  gcagcaaaa  480
caagaaggc  gagaacagg  ctaggtcca  agagaaagc  gaaggtggg  acagctcca  540
ggagaagaa  aaagacaag  acgacaagg  ggacgagaa  gagaaggat  ctgggaatt  600
tgaccagaa  aagctggaa  aagaaatga  aaaacgaaa  gaaagggtt  aaaaatggc  660
agaagagca  cgtaaaaag  cgatggaga  catagggga  ctgaagaag  agatcgagg  720
gatgaagca  gggaagaag  ggagcctgg  agatgacga  gatgatgaa  atgaccctg  780
cgaggctga  aaggaaggg  atgaaatgg  ggacgagga  ctggaccca  tagatgcct  840
catggagga  gtgaaagaa  aggtaaaaa  gtttaacat  aggagcgtg  aaggcggcg  900
aggaaatga  aagaagtcc  ggccaacgg  cacaaaagt  gtcactgtt  tgacaacca  960
aaaagcagt  gtggattct  ataagaaga  aggtgagct  atggagaat  accaggatg  1020
catggagta  tcttcagag  aggaagaag  tgatcttca  acagccctt  cagggtatc  1080
aacaaaaca  cgaaaactt  tagaaccag  tgatcatgg  aaaattgag  atgagccat  1140
taggaaaaa  ttctatgtt  aagttccag  actagcaaa  atgtctcaa  aagaggtaa  1200
tgtgtttcg  ttggaaatg  agggcatta  agttaaagg  aaaggttgc  ccaaaccaa  1260
taaatcctg  gtccagtgt  gaatttcca  gaagatctt  aattccctc  agaagcatg  1320
ctatgaaaa  cccacgccc  tccaaaccc  agctattcc  gctataatg  ctggacgag  1380
tttgattgg  attgccaaa  caggaagtg  aaagaccat  gcttttctg  tgcccatgt  1440
tagacacat  atggatcag  ggtcattag  ggaaggaga  gggccatta  ctgtcatca  1500
gactcccac  cgagaactg  ctttacaga  acctaaggg  gtaagaagt  tcaagactt  1560
gggacttag  gtggtctgt  tttacggag  aacaggaat  agtgagcag  ttgctgagc  1620
gaaaagagg  gctgaaatt  ttgtttgca  acctggtcg  atgattgac  tgttagccg  1680
taacagtgg  cgggtcaca  atcttcgaa  agtgacata  gttgtttta  atgaagcag  1740
cagaatgtt  gacatgggt  ttgaacccc  ggtcatgcg  atcgtggat  atgttcgtc  1800
tgatcgaca  acggttatg  tttcagcta  tttcccaag  gctatggaa  cgttggccc  1860
caggatctt  agcaagccc  ttgaagttc  ggttggagg  cggagtgtg  tttgctcag  1920
tgtggaaca  caagtgatt  tgattgaag  agagaagaa  ttcttgaaa  tgctggagc  1980
tttaggcca  tatcaggag  caggatctg  cattatatt  gtggataag  aggaacacg  2040
tgatggtct  ctgaaggat  taatgagag  atcttatcc  tgcatgtct  ttcatggag  2100
cattgatca  tatgacaga  atagcatca  aaatgactt  aagaatggg  cctgcaaac  2160
tcttgtggc  acctctgtt  ctgcccgag  tctagatgt  aaacatctg  ttcttgtag  2220
aaattatag  tgccccaac  attatgagg  ttatgtaca  agagcaggg  ggactggaa  2280
agcaggaaa  aagggttat  cttatactt  tatcacaga  gatcaagct  gctatgctg  2340
tgacataat  aaagctctt  aattgtcgg  gactgcggt  cctcctgac  tagagaaac  2400
atggagtga  ttcaaagat  agcagaaag  tgaaggaaa  ataattaaa  agagcagcg  2460
cttctctgg  aaggggttc  agtttgatg  gacagagca  gctttagcc  atgagagga  2520
aaagctaca  aaagctgcc  ttggcctgc  agattcaga  gatgaggat  ctgcagttg  2580
tattgatga  caaattgaa  gcatgttta  ttcaaagaa  agagtaaag  atatggctg  2640
tcctggaac  tcaagtgtt  ctgctccaa  tgcaggaaa  gctgagaaa  tagaaattg  2700
taagagatt  gctcttaga  tcaatgccc  gaagaattt  ggcatcgag  ctcaggtag  2760
tgtgatgca  caggccacc  atgcaattc  taggggtgg  accattctg  ctcccactg  2820
ttctgcaaa  accattgca  aacaacttg  tgaaaagat  aatgccaag  tcaattatg  2880
gccgttaga  aaacaagaa  aagagagac  ggatggtgg  cagaatgaa  cttttaaga  2940
atatgaaga  gaattagag  tcaatgact  cccacagac  gctaggtgg  aagttacct  3000
taaggaagc  ctgcagaga  tcagtgaat  ctctgaagc  gcaattaca  tcagaggaa  3060
ctacttccc  cctggcaaa  aacccaagg  aggcgagcg  aagatttac  tggcaattg  3120
aagtgccaa  gaactggct  tgcagaaag  aaaggcaga  atcaccagg  tcataaaag  3180
agagctgat  cggctgcaa  attcatacc  accaacaaa  aaaggaaga  acaaagtct  3240
atagacatc  ggaaaaaag  tttttacct  tgctggtct  tgatgtatg  ggcagttgc  3300
gtctgcagt  tacaatgta  tgtaaatga  gatttttta  attctatct  gctgatttt  3360
tttaaatat  agaaactgg  acttggtaa  gaaatctgt  cgtaagtac  cccacaatc  3420
gtcaaacta  atttaaagc  agcctgttt  cagagtatg  tgtccttta  tgtaaactc  3480
aatatcaat  ttttaaatg  ccggataat  ttctagagg  ttaaaaaat  gaaatattt  3540
aactttcta  tgaagacaa  aaagtacac  agtcgttaa  gggctattc  ctttatcct  3600
tactttcaa  gaaattgtg  tcatttcct  agaaaaggt  aaattcact  tcatatttt  3660
tgtccccac  ttgatgtta  atgactctg  aacaatatg  actggattt  agaatgtta  3720
aatagaagt  ttacaaaat  gaaaaa  3746



<210> 8288
<211> 1032
<212> PRT
<213> Homo sapiens
<308> BAA34521
<400> 8288

Met Gly Arg Glu Ser Arg His Tyr Arg Lys Arg Ser Ala Ser Arg Gly 
  1               5                  10                  15
Arg Ser Gly Ser Arg Ser Arg Ser Arg Ser Pro Ser Asp Lys Arg Ser 
             20                  25                  30
Lys Arg Gly Asp Asp Arg Arg Ser Arg Ser Arg Asp Arg Asp Arg Arg 
         35                  40                  45
Arg Glu Arg Ser Arg Ser Arg Asp Lys Arg Arg Ser Arg Ser Arg Asp 
     50                  55                  60
Arg Lys Arg Leu Arg Arg Ser Arg Ser Arg Glu Arg Asp Arg Ser Arg 
 65                  70                  75                  80
Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser Arg 
                 85                  90                  95
Ser Arg Gly Arg Arg Ser Arg Ser Ser Ser Pro Gly Asn Lys Ser Lys 
             100                105                110
Lys Thr Glu Asn Arg Ser Arg Ser Lys Glu Lys Thr Asp Gly Gly Glu 
         115                120                125
Ser Ser Lys Glu Lys Lys Lys Asp Lys Asp Asp Lys Glu Asp Glu Lys 
     130                135                140
Glu Lys Asp Ala Gly Asn Phe Asp Gln Asn Lys Leu Glu Glu Glu Met 
 145                150                155                160
Arg Lys Arg Lys Glu Arg Val Glu Lys Trp Arg Glu Glu Gln Arg Lys 
                 165                170                175
Lys Ala Met Glu Asn Ile Gly Glu Leu Lys Lys Glu Ile Glu Glu Met 
             180                185                190
Lys Gln Gly Lys Lys Trp Ser Leu Glu Asp Asp Asp Asp Asp Glu Asp 
         195                200                205
Asp Pro Ala Glu Ala Glu Lys Glu Gly Asn Glu Met Glu Gly Glu Glu 
     210                215                220
Leu Asp Pro Leu Asp Ala Tyr Met Glu Glu Val Lys Glu Glu Val Lys 
 225                230                235                240
Lys Phe Asn Met Arg Ser Val Lys Gly Gly Gly Gly Asn Glu Lys Lys 
                 245                250                255
Ser Gly Pro Thr Val Thr Lys Val Val Thr Val Val Thr Thr Lys Lys 
             260                265                270
Ala Val Val Asp Ser Asp Lys Lys Lys Gly Glu Leu Met Glu Asn Asp 
         275                280                285
Gln Asp Ala Met Glu Tyr Ser Ser Glu Glu Glu Glu Val Asp Leu Gln 
     290                295                300
Thr Ala Leu Thr Gly Tyr Gln Thr Lys Gln Arg Lys Leu Leu Glu Pro 
 305                310                315                320
Val Asp His Gly Lys Ile Glu Tyr Glu Pro Phe Arg Lys Asn Phe Tyr 
                 325                330                335
Val Glu Val Pro Glu Leu Ala Lys Met Ser Gln Glu Glu Val Asn Val 
             340                345                350
Phe Arg Leu Glu Met Glu Gly Ile Thr Val Lys Gly Lys Gly Cys Pro 
         355                360                365
Lys Pro Ile Lys Ser Trp Val Gln Cys Gly Ile Ser Met Lys Ile Leu 
     370                375                380
Asn Ser Leu Lys Lys His Gly Tyr Glu Lys Pro Thr Pro Ile Gln Thr 
 385                390                395                400
Gln Ala Ile Pro Ala Ile Met Ser Gly Arg Asp Leu Ile Gly Ile Ala 
                 405                410                415
Lys Thr Gly Ser Gly Lys Thr Ile Ala Phe Leu Leu Pro Met Phe Arg 
             420                425                430
His Ile Met Asp Gln Arg Ser Leu Glu Glu Gly Glu Gly Pro Ile Ala 
         435                440                445
Val Ile Met Thr Pro Thr Arg Glu Leu Ala Leu Gln Ile Thr Lys Glu 
     450                455                460
Cys Lys Lys Phe Ser Lys Thr Leu Gly Leu Arg Val Val Cys Val Tyr 
 465                470                475                480
Gly Gly Thr Gly Ile Ser Glu Gln Ile Ala Glu Leu Lys Arg Gly Ala 
                 485                490                495
Glu Ile Ile Val Cys Thr Pro Gly Arg Met Ile Asp Met Leu Ala Ala 
             500                505                510
Asn Ser Gly Arg Val Thr Asn Leu Arg Arg Val Thr Tyr Val Val Leu 
         515                520                525
Asp Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Pro Gln Val Met 
     530                535                540
Arg Ile Val Asp Asn Val Arg Pro Asp Arg Gln Thr Val Met Phe Ser 
 545                550                555                560
Ala Thr Phe Pro Arg Ala Met Glu Ala Leu Ala Arg Arg Ile Leu Ser 
                 565                570                575
Lys Pro Ile Glu Val Gln Val Gly Gly Arg Ser Val Val Cys Ser Asp 
             580                585                590
Val Glu Gln Gln Val Ile Val Ile Glu Glu Glu Lys Lys Phe Leu Lys 
         595                600                605
Leu Leu Glu Leu Leu Gly His Tyr Gln Glu Ser Gly Ser Val Ile Ile 
     610                615                620
Phe Val Asp Lys Gln Glu His Ala Asp Gly Leu Leu Lys Asp Leu Met 
 625                630                635                640
Arg Ala Ser Tyr Pro Cys Met Ser Leu His Gly Gly Ile Asp Gln Tyr 
                 645                650                655
Asp Arg Asp Ser Ile Ile Asn Asp Phe Lys Asn Gly Thr Cys Lys Leu 
             660                665                670
Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Val Lys His Leu 
         675                680                685
Ile Leu Val Val Asn Tyr Ser Cys Pro Asn His Tyr Glu Asp Tyr Val 
     690                695                700
His Arg Ala Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Tyr Ala Tyr 
 705                710                715                720
Thr Phe Ile Thr Glu Asp Gln Ala Arg Tyr Ala Gly Asp Ile Ile Lys 
                 725                730                735
Ala Leu Glu Leu Ser Gly Thr Ala Val Pro Pro Asp Leu Glu Lys Leu 
             740                745                750
Trp Ser Asp Phe Lys Asp Gln Gln Lys Ala Glu Gly Lys Ile Ile Lys 
         755                760                765
Lys Ser Ser Gly Phe Ser Gly Lys Gly Phe Lys Phe Asp Glu Thr Glu 
     770                775                780
Gln Ala Leu Ala Asn Glu Arg Lys Lys Leu Gln Lys Ala Ala Leu Gly 
 785                790                795                800
Leu Gln Asp Ser Asp Asp Glu Asp Ala Ala Val Asp Ile Asp Glu Gln 
                 805                810                815
Ile Glu Ser Met Phe Asn Ser Lys Lys Arg Val Lys Asp Met Ala Ala 
             820                825                830
Pro Gly Thr Ser Ser Val Pro Ala Pro Thr Ala Gly Asn Ala Glu Lys 
         835                840                845
Leu Glu Ile Ala Lys Arg Leu Ala Leu Arg Ile Asn Ala Gln Lys Asn 
     850                855                860
Leu Gly Ile Glu Ser Gln Val Asp Val Met Gln Gln Ala Thr Asn Ala 
 865                870                875                880
Ile Leu Arg Gly Gly Thr Ile Leu Ala Pro Thr Val Ser Ala Lys Thr 
                 885                890                895
Ile Ala Glu Gln Leu Ala Glu Lys Ile Asn Ala Lys Leu Asn Tyr Val 
             900                905                910
Pro Leu Glu Lys Gln Glu Glu Glu Arg Gln Asp Gly Gly Gln Asn Glu 
         915                920                925
Ser Phe Lys Arg Tyr Glu Glu Glu Leu Glu Ile Asn Asp Phe Pro Gln 
     930                935                940
Thr Ala Arg Trp Lys Val Thr Ser Lys Glu Ala Leu Gln Arg Ile Ser 
 945                950                955                960
Glu Tyr Ser Glu Ala Ala Ile Thr Ile Arg Gly Thr Tyr Phe Pro Pro 
                 965                970                975
Gly Lys Glu Pro Lys Glu Gly Glu Arg Lys Ile Tyr Leu Ala Ile Glu 
             980                985                990
Ser Ala Asn Glu Leu Ala Val Gln Lys Ala Lys Ala Glu Ile Thr Arg 
         995                1000                1005
Leu Ile Lys Glu Glu Leu Ile Arg Leu Gln Asn Ser Tyr Gln Pro Thr 
     1010                1015                1020
Asn Lys Gly Arg Tyr Lys Val Leu 
 1025                1030



<210> 8289
<211> 3531
<212> DNA
<213> Rattus norvegicus
<308> U25746
<400> 8289

cacgctctg  tggcggtca  tgctggagc  ttggccatt  cgtagggcc  gtcctcgct  60
ggtactgtg  ggacttggt  cctccctcc  ttgtcctct  caccggtct  cgcatcgtc  120
ccaagggcg  aggccttcc  ctggctggc  gcatgggca  ggagtctcg  cattaccga  180
aacggtcag  atctcgagg  cgctctgga  gtcggtcta  gagtcgctc  ccctctgac  240
aaagaagca  acgtggaga  gacaggcgt  ccaggagta  agacagaga  agaaggaga  300
agaggtctc  gagcaggga  aaaaggaga  ctcggtcac  ggacaggaa  cgcctgaga  360
gttccagaa  tagagagcg  gacagaagc  gagagcgaa  aagatctcg  agccgggat  420
gaaggcgct  aaggagtcg  agccggggc  ggcggtccc  gtcttccag  cctggcagc  480
aaagcaaga  ggctgagaa  aggtctagg  ccaaagaga  agcagaagg  ggggacagc  540
ccaaggaga  gaagaaaga  aaggacgac  aggaggacg  gaaagagaa  gatgctggg  600
attttgacc  gaataagct  gaagaagaa  tgagaaaac  aaaagaaag  gttgaaaaa  660
ggcgagaag  gcagcgtaa  aaggcgatg  agaacatag  ggagctgaa  aaggagatc  720
aggagatga  gcaggggaa  aagtggagc  tggaagatg  cgacgatga  gaagatgac  780
ctgccgagg  tgagaagga  gggaatgaa  tggaggacg  ggagctgga  ccattagat  840
cctacatgg  ggaagtgaa  gaagaggta  aaaagttta  catgaggag  gtgaaaggc  900
gcgcaggaa  tgagaagaa  tccggaccg  ctgtcacga  agtggttac  gtggtaaca  960
ccaagaaag  agtagtaga  gccgacaag  agaagggag  gctgatgga  aatgaccag  1020
acgccatgg  gtactcctc  gaggaggaa  aggttgacc  tcagacggc  ctcacaggc  1080
accagacaa  acagagaaa  cttctagag  cagtggatc  tgggaaaat  gagtatgag  1140
cattcagaa  aaactttta  gttgaagtt  cagaattag  gaaaatgtc  caagaagag  1200
tgaatgtgt  tcggttgga  atggagggc  ttacagtta  aggaaaagg  tgccccaag  1260
caattaaat  atgggtcca  tgtggaatt  ccatgaaga  actgaattc  ctcaaaaag  1320
atggctatg  aaagcccac  ccaatccaa  ctcaagcaa  tcctgctat  atgtctgga  1380
gagatttga  tggcattgc  aagacagga  gtggaaaaa  cattgcttt  cttttgccc  1440
tgtttagac  catcatgga  cagaggtca  tggaagaag  agagggacc  atcgctgtc  1500
tcatgactc  aactcgaga  ctggcttta  aaatcacta  agaatgtaa  aagttttcg  1560
agaccttgg  actgagagt  gtctgtgtg  atggaggga  aggaatcag  gagcagatt  1620
ctgagctga  gagaggcgc  gagatcatt  tttgcacac  tggccggat  atcgacatg  1680
tggcagcta  cagtggtcg  gtcacaaat  ttcgaagag  gacatatgt  gttttagat  1740
aagcagaca  aatgtttga  atgggtttt  aaccacagg  catgcgcat  gtggacaat  1800
tccgtcctg  ccgacagac  gttatgttc  cagctactt  cccaagagc  atggaagcg  1860
tggcccgca  gatcttgag  aagcccatt  aagttcagg  tggaggccg  agtgtggtt  1920
gctcagatg  ggaacaaca  gtgattgtg  ttgaagaag  gaagaaatt  ttgaaattg  1980
tggagcttt  aggccatta  caggagtca  gatctgtca  tatatttgt  gataagcag  2040
aacacgctg  tggtcttct  aaggacttg  tgagagctt  ctacccttg  atgtctctt  2100
acggaggta  tgatcagta  gacagggac  gtatcataa  tgactttaa  aatggaacc  2160
gcaaacttc  cgtagccac  tctgttgcc  cccgtggtc  agatgtgaa  catctcatt  2220
ttgtagtaa  ttacagctg  cccaatcat  acgaagatt  cgtgcacag  gctgggcgg  2280
ctggaagag  aggcaacaa  ggttatgcc  acaccttca  cacagaaga  caagctcga  2340
atgctgggg  catcattaa  gctcttgaa  tgtcgggga  ggcggtgcc  cctgaccta  2400
agaaactat  gagtgactt  aaagatcag  agaaagctg  aggaaaaat  attaaaaag  2460
gcagcggct  ctctggcaa  gggttcaag  ttgatgaga  agagcaggc  ttagccaat  2520
agaggaaaa  gctacaaaa  gctgccctt  gcctgcagg  ttctgatga  gaggacgcc  2580
cagttgata  tgacgagca  attgaaagc  tgtttaatt  caagaagag  gtgaaagac  2640
tggctgctc  cggcacatc  agtgcgcct  ctccgactg  gggcaatgc  gagaagcta  2700
agattgcca  gaggttggc  cttagaatc  acgctcaga  gaacctggg  atcgagtct  2760
aggtagatg  gatgcagca  gccacaaat  ccatcctca  aggtggccc  cttctggct  2820
ccaccgtgt  tgcaaaaac  atcgcagag  agcttgccg  gaagatcaa  gccaagctc  2880
attacgtgc  tttggagaa  caggaagaa  agagacagg  gggtgggca  agcgaatct  2940
tcaagagat  cgaggaaga  ttagaaatt  atgacttcc  acagacggc  aggtggaaa  3000
ttacctcta  ggaagcctt  cagaggatc  gtgagtact  ggaagccgc  atcacaatc  3060
gagggacct  cttcccgcc  ggcaaagag  ccaaggaag  agagcggaa  atctacttg  3120
cgattgaaa  tgccaacga  ctggctgtg  agaaagcaa  ggcagagat  accaggctc  3180
taaaagagg  gctgatccg  ctgcaaaat  cataccaac  caccaacaa  ggacgatac  3240
aagtattat  aacaccgga  ccactttgt  cccgtgcta  ctgtgacgt  tacagtgta  3300
tgtaaagta  gacttttaa  attctgtct  gcttatttt  taagtacaa  aaaccagtg  3360
ttgttcaag  ggtcatctg  aagtactac  ctataccca  ccaaactcc  tttaaatca  3420
agctgtttt  agagtgtga  gttcttcga  gtaaacctt  gataccaac  ctttaaata  3480
ctggagaca  tgggatttt  tactgaatg  agtaataaa  tgtgtcagg  a  3531



<210> 8290
<211> 1033
<212> PRT
<213> Rattus norvegicus
<308> U25746
<400> 8290

Met Gly Arg Glu Ser Arg His Tyr Arg Lys Arg Ser Ala Ser Arg Gly 
  1               5                  10                  15
Arg Ser Gly Ser Arg Ser Arg Ser Arg Ser Pro Ser Asp Lys Arg Ser 
             20                  25                  30
Lys Arg Gly Asp Asp Arg Arg Ser Arg Ser Arg Asp Arg Asp Arg Arg 
         35                  40                  45
Arg Glu Arg Ser Arg Ser Arg Asp Lys Arg Arg Ser Arg Ser Arg Asp 
     50                  55                  60
Arg Lys Arg Leu Arg Arg Ser Arg Ser Arg Glu Arg Asp Arg Ser Arg 
 65                  70                  75                  80
Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser Arg 
                 85                  90                  95
Ser Arg Gly Arg Arg Ser Arg Ser Ser Ser Pro Gly Ser Lys Ser Lys 
             100                105                110
Lys Ala Glu Asn Arg Ser Arg Ser Lys Glu Lys Ala Glu Gly Gly Asp 
         115                120                125
Ser Ser Lys Glu Lys Lys Lys Asp Lys Asp Asp Lys Glu Asp Glu Lys 
     130                135                140
Glu Lys Asp Ala Gly Asn Phe Asp Gln Asn Lys Leu Glu Glu Glu Met 
 145                150                155                160
Arg Lys Arg Lys Glu Arg Val Glu Lys Trp Arg Glu Glu Gln Arg Lys 
                 165                170                175
Lys Ala Met Glu Asn Ile Gly Glu Leu Lys Lys Glu Ile Glu Glu Met 
             180                185                190
Lys Gln Gly Lys Lys Trp Ser Leu Glu Asp Asp Asp Asp Asp Glu Asp 
         195                200                205
Asp Pro Ala Glu Ala Glu Lys Glu Gly Asn Glu Met Glu Asp Glu Glu 
     210                215                220
Leu Asp Pro Leu Asp Ala Tyr Met Glu Glu Val Lys Glu Glu Val Lys 
 225                230                235                240
Lys Phe Asn Met Arg Ser Val Lys Gly Gly Ala Gly Asn Glu Lys Lys 
                 245                250                255
Ser Gly Pro Thr Val Thr Lys Val Val Thr Val Val Thr Thr Lys Lys 
             260                265                270
Ala Val Val Asp Ala Asp Lys Lys Lys Gly Glu Leu Met Glu Asn Asp 
         275                280                285
Gln Asp Ala Met Glu Tyr Ser Ser Glu Glu Glu Glu Val Asp Leu Gln 
     290                295                300
Thr Ala Leu Thr Gly Tyr Gln Thr Lys Gln Arg Lys Leu Leu Glu Pro 
 305                310                315                320
Val Asp His Gly Lys Ile Glu Tyr Glu Pro Phe Arg Lys Asn Phe Tyr 
                 325                330                335
Val Glu Val Pro Glu Leu Ala Lys Met Ser Gln Glu Glu Val Asn Val 
             340                345                350
Phe Arg Leu Glu Met Glu Gly Ile Thr Val Lys Gly Lys Gly Cys Pro 
         355                360                365
Lys Pro Ile Lys Ser Trp Val Gln Cys Gly Ile Ser Met Lys Ile Leu 
     370                375                380
Asn Ser Leu Lys Lys His Gly Tyr Glu Lys Pro Thr Pro Ile Gln Thr 
 385                390                395                400
Gln Ala Ile Pro Ala Ile Met Ser Gly Arg Asp Leu Ile Gly Ile Ala 
                 405                410                415
Lys Thr Gly Ser Gly Lys Thr Ile Ala Phe Leu Leu Pro Met Phe Arg 
             420                425                430
His Ile Met Asp Gln Arg Ser Leu Glu Glu Gly Glu Gly Pro Ile Ala 
         435                440                445
Val Ile Met Thr Pro Thr Arg Glu Leu Ala Leu Gln Ile Thr Lys Glu 
     450                455                460
Cys Lys Lys Phe Ser Lys Thr Leu Gly Leu Arg Val Val Cys Val Tyr 
 465                470                475                480
Gly Gly Thr Gly Ile Ser Glu Gln Ile Ala Glu Leu Lys Arg Gly Ala 
                 485                490                495
Glu Ile Ile Val Cys Thr Pro Gly Arg Met Ile Asp Met Leu Ala Ala 
             500                505                510
Asn Ser Gly Arg Val Thr Asn Leu Arg Arg Val Thr Tyr Val Val Leu 
         515                520                525
Asp Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Pro Gln Val Met 
     530                535                540
Arg Ile Val Asp Asn Val Arg Pro Asp Arg Gln Thr Val Met Phe Ser 
 545                550                555                560
Ala Thr Phe Pro Arg Ala Met Glu Ala Leu Ala Arg Arg Ile Leu Ser 
                 565                570                575
Lys Pro Ile Glu Val Gln Val Gly Gly Arg Ser Val Val Cys Ser Asp 
             580                585                590
Val Glu Gln Gln Val Ile Val Ile Glu Glu Glu Lys Lys Phe Leu Lys 
         595                600                605
Leu Leu Glu Leu Leu Gly His Tyr Gln Glu Ser Gly Ser Val Ile Ile 
     610                615                620
Phe Val Asp Lys Gln Glu His Ala Asp Gly Leu Leu Lys Asp Leu Met 
 625                630                635                640
Arg Ala Ser Tyr Pro Cys Met Ser Leu His Gly Gly Ile Asp Gln Tyr 
                 645                650                655
Asp Arg Asp Ser Ile Ile Asn Asp Phe Lys Asn Gly Thr Cys Lys Leu 
             660                665                670
Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Val Lys His Leu 
         675                680                685
Ile Leu Val Val Asn Tyr Ser Cys Pro Asn His Tyr Glu Asp Tyr Val 
     690                695                700
His Arg Ala Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Tyr Ala Tyr 
 705                710                715                720
Thr Phe Ile Thr Glu Asp Gln Ala Arg Tyr Ala Gly Asp Ile Ile Lys 
                 725                730                735
Ala Leu Glu Leu Ser Gly Thr Ala Val Pro Pro Asp Leu Glu Lys Leu 
             740                745                750
Trp Ser Asp Phe Lys Asp Gln Gln Lys Ala Glu Gly Lys Ile Ile Lys 
         755                760                765
Lys Ser Ser Gly Phe Ser Gly Lys Gly Phe Lys Phe Asp Glu Thr Glu 
     770                775                780
Gln Ala Leu Ala Asn Glu Arg Lys Lys Leu Gln Lys Ala Ala Leu Gly 
 785                790                795                800
Leu Gln Asp Ser Asp Asp Glu Asp Ala Ala Val Asp Ile Asp Glu Gln 
                 805                810                815
Ile Glu Ser Met Phe Asn Ser Lys Lys Arg Val Lys Asp Met Ala Ala 
             820                825                830
Pro Gly Thr Ser Ser Ala Pro Ala Pro Thr Ala Gly Asn Ala Glu Lys 
         835                840                845
Leu Glu Ile Ala Lys Arg Leu Ala Leu Arg Ile Asn Ala Gln Lys Asn 
     850                855                860
Leu Gly Ile Glu Ser Gln Val Asp Val Met Gln Gln Ala Thr Asn Ala 
 865                870                875                880
Ile Leu Arg Gly Gly Pro Leu Leu Ala Pro Thr Val Ser Ala Lys Thr 
                 885                890                895
Ile Ala Glu Gln Leu Ala Glu Lys Ile Asn Ala Lys Leu Asn Tyr Val 
             900                905                910
Pro Leu Glu Lys Gln Glu Glu Glu Arg Gln Glu Gly Gly Gln Ser Glu 
         915                920                925
Ser Phe Lys Arg Tyr Glu Glu Glu Leu Glu Ile Asn Asp Phe Pro Gln 
     930                935                940
Thr Ala Arg Trp Lys Val Thr Ser Lys Glu Ala Leu Gln Arg Ile Ser 
 945                950                955                960
Glu Tyr Ser Glu Ala Ala Ile Thr Ile Arg Gly Thr Tyr Phe Pro Pro 
                 965                970                975
Gly Lys Glu Pro Lys Glu Gly Glu Arg Lys Ile Tyr Leu Ala Ile Glu 
             980                985                990
Ser Ala Asn Glu Leu Ala Val Gln Lys Ala Lys Ala Glu Ile Thr Arg 
         995                1000                1005
Leu Ile Lys Glu Glu Leu Ile Arg Leu Gln Asn Ser Tyr Gln Pro Thr 
     1010                1015                1020
Asn Lys Gly Arg Tyr Lys Val Leu Ter 
 1025                1030



<210> 8291
<211> 3746
<212> DNA
<213> Homo sapiens
<308> AF106680
<400> 8291

cccgcgctg  gatggccgc  acagctgta  gtgctgcta  tgtttagcg  tggtctttg  60
cgggcgttg  gggcagctc  gcctccttg  ttgtccggt  cgcctgtgc  tggtactca  120
gggcaccag  attcccgcg  tcggcagca  gggtcggga  tcacgccac  atcgaaaac  180
atcggcatc  cggggtcgc  ctggaagtc  gtctagaag  cgctcaccc  cagacaaaa  240
aagtaaacg  ggagatgac  gacggtcta  aagtagaga  agagatagg  ggagagaga  300
gtctcgtag  agggataaa  gaagatctc  gtcaaggga  aggaagcgt  tgagacgtt  360
cagaagtag  gagagagac  gaagccgag  gcgaagaag  tctcgaagt  gagacagga  420
acgctcaag  agtagaagc  ggggccggc  atcccgatc  tccagtcct  gcagcaaaa  480
caagaaggc  gagaacagg  ctaggtcca  agagaaagc  gaaggtggg  acagctcca  540
ggagaagaa  aaagacaag  acgacaagg  ggacgagaa  gagaaggat  ctgggaatt  600
tgaccagaa  aagctggaa  aagaaatga  aaaacgaaa  gaaagggtt  aaaaatggc  660
agaagagca  cgtaaaaag  cgatggaga  catagggga  ctgaagaag  agatcgagg  720
gatgaagca  gggaagaag  ggagcctgg  agatgacga  gatgatgaa  atgaccctg  780
cgaggctga  aaggaaggg  atgaaatgg  ggacgagga  ctggaccca  tagatgcct  840
catggagga  gtgaaagaa  aggtaaaaa  gtttaacat  aggagcgtg  aaggcggcg  900
aggaaatga  aagaagtcc  ggccaacgg  cacaaaagt  gtcactgtt  tgacaacca  960
aaaagcagt  gtggattct  ataagaaga  aggtgagct  atggagaat  accaggatg  1020
catggagta  tcttcagag  aggaagaag  tgatcttca  acagccctt  cagggtatc  1080
aacaaaaca  cgaaaactt  tagaaccag  tgatcatgg  aaaattgag  atgagccat  1140
taggaaaaa  ttctatgtt  aagttccag  actagcaaa  atgtctcaa  aagaggtaa  1200
tgtgtttcg  ttggaaatg  agggcatta  agttaaagg  aaaggttgc  ccaaaccaa  1260
taaatcctg  gtccagtgt  gaatttcca  gaagatctt  aattccctc  agaagcatg  1320
ctatgaaaa  cccacgccc  tccaaaccc  agctattcc  gctataatg  ctggacgag  1380
tttgattgg  attgccaaa  caggaagtg  aaagaccat  gcttttctg  tgcccatgt  1440
tagacacat  atggatcag  ggtcattag  ggaaggaga  gggccatta  ctgtcatca  1500
gactcccac  cgagaactg  ctttacaga  acctaaggg  gtaagaagt  tcaagactt  1560
gggacttag  gtggtctgt  tttacggag  aacaggaat  agtgagcag  ttgctgagc  1620
gaaaagagg  gctgaaatt  ttgtttgca  acctggtcg  atgattgac  tgttagccg  1680
taacagtgg  cgggtcaca  atcttcgaa  agtgacata  gttgtttta  atgaagcag  1740
cagaatgtt  gacatgggt  ttgaacccc  ggtcatgcg  atcgtggat  atgttcgtc  1800
tgatcgaca  acggttatg  tttcagcta  tttcccaag  gctatggaa  cgttggccc  1860
caggatctt  agcaagccc  ttgaagttc  ggttggagg  cggagtgtg  tttgctcag  1920
tgtggaaca  caagtgatt  tgattgaag  agagaagaa  ttcttgaaa  tgctggagc  1980
tttaggcca  tatcaggag  caggatctg  cattatatt  gtggataag  aggaacacg  2040
tgatggtct  ctgaaggat  taatgagag  atcttatcc  tgcatgtct  ttcatggag  2100
cattgatca  tatgacaga  atagcatca  aaatgactt  aagaatggg  cctgcaaac  2160
tcttgtggc  acctctgtt  ctgcccgag  tctagatgt  aaacatctg  ttcttgtag  2220
aaattatag  tgccccaac  attatgagg  ttatgtaca  agagcaggg  ggactggaa  2280
agcaggaaa  aagggttat  cttatactt  tatcacaga  gatcaagct  gctatgctg  2340
tgacataat  aaagctctt  aattgtcgg  gactgcggt  cctcctgac  tagagaaac  2400
atggagtga  ttcaaagat  agcagaaag  tgaaggaaa  ataattaaa  agagcagcg  2460
cttctctgg  aaggggttc  agtttgatg  gacagagca  gctttagcc  atgagagga  2520
aaagctaca  aaagctgcc  ttggcctgc  agattcaga  gatgaggat  ctgcagttg  2580
tattgatga  caaattgaa  gcatgttta  ttcaaagaa  agagtaaag  atatggctg  2640
tcctggaac  tcaagtgtt  ctgctccaa  tgcaggaaa  gctgagaaa  tagaaattg  2700
taagagatt  gctcttaga  tcaatgccc  gaagaattt  ggcatcgag  ctcaggtag  2760
tgtgatgca  caggccacc  atgcaattc  taggggtgg  accattctg  ctcccactg  2820
ttctgcaaa  accattgca  aacaacttg  tgaaaagat  aatgccaag  tcaattatg  2880
gccgttaga  aaacaagaa  aagagagac  ggatggtgg  cagaatgaa  cttttaaga  2940
atatgaaga  gaattagag  tcaatgact  cccacagac  gctaggtgg  aagttacct  3000
taaggaagc  ctgcagaga  tcagtgaat  ctctgaagc  gcaattaca  tcagaggaa  3060
ctacttccc  cctggcaaa  aacccaagg  aggcgagcg  aagatttac  tggcaattg  3120
aagtgccaa  gaactggct  tgcagaaag  aaaggcaga  atcaccagg  tcataaaag  3180
agagctgat  cggctgcaa  attcatacc  accaacaaa  aaaggaaga  acaaagtct  3240
atagacatc  ggaaaaaag  tttttacct  tgctggtct  tgatgtatg  ggcagttgc  3300
gtctgcagt  tacaatgta  tgtaaatga  gatttttta  attctatct  gctgatttt  3360
tttaaatat  agaaactgg  acttggtaa  gaaatctgt  cgtaagtac  cccacaatc  3420
gtcaaacta  atttaaagc  agcctgttt  cagagtatg  tgtccttta  tgtaaactc  3480
aatatcaat  ttttaaatg  ccggataat  ttctagagg  ttaaaaaat  gaaatattt  3540
aactttcta  tgaagacaa  aaagtacac  agtcgttaa  gggctattc  ctttatcct  3600
tactttcaa  gaaattgtg  tcatttcct  agaaaaggt  aaattcact  tcatatttt  3660
tgtccccac  ttgatgtta  atgactctg  aacaatatg  actggattt  agaatgtta  3720
aatagaagt  ttacaaaat  gaaaaa  3746



<210> 8292
<211> 1032
<212> PRT
<213> Homo sapiens
<308> BAA34521
<400> 8292

Met Gly Arg Glu Ser Arg His Tyr Arg Lys Arg Ser Ala Ser Arg Gly 
  1               5                  10                  15
Arg Ser Gly Ser Arg Ser Arg Ser Arg Ser Pro Ser Asp Lys Arg Ser 
             20                  25                  30
Lys Arg Gly Asp Asp Arg Arg Ser Arg Ser Arg Asp Arg Asp Arg Arg 
         35                  40                  45
Arg Glu Arg Ser Arg Ser Arg Asp Lys Arg Arg Ser Arg Ser Arg Asp 
     50                  55                  60
Arg Lys Arg Leu Arg Arg Ser Arg Ser Arg Glu Arg Asp Arg Ser Arg 
 65                  70                  75                  80
Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser Arg 
                 85                  90                  95
Ser Arg Gly Arg Arg Ser Arg Ser Ser Ser Pro Gly Asn Lys Ser Lys 
             100                105                110
Lys Thr Glu Asn Arg Ser Arg Ser Lys Glu Lys Thr Asp Gly Gly Glu 
         115                120                125
Ser Ser Lys Glu Lys Lys Lys Asp Lys Asp Asp Lys Glu Asp Glu Lys 
     130                135                140
Glu Lys Asp Ala Gly Asn Phe Asp Gln Asn Lys Leu Glu Glu Glu Met 
 145                150                155                160
Arg Lys Arg Lys Glu Arg Val Glu Lys Trp Arg Glu Glu Gln Arg Lys 
                 165                170                175
Lys Ala Met Glu Asn Ile Gly Glu Leu Lys Lys Glu Ile Glu Glu Met 
             180                185                190
Lys Gln Gly Lys Lys Trp Ser Leu Glu Asp Asp Asp Asp Asp Glu Asp 
         195                200                205
Asp Pro Ala Glu Ala Glu Lys Glu Gly Asn Glu Met Glu Gly Glu Glu 
     210                215                220
Leu Asp Pro Leu Asp Ala Tyr Met Glu Glu Val Lys Glu Glu Val Lys 
 225                230                235                240
Lys Phe Asn Met Arg Ser Val Lys Gly Gly Gly Gly Asn Glu Lys Lys 
                 245                250                255
Ser Gly Pro Thr Val Thr Lys Val Val Thr Val Val Thr Thr Lys Lys 
             260                265                270
Ala Val Val Asp Ser Asp Lys Lys Lys Gly Glu Leu Met Glu Asn Asp 
         275                280                285
Gln Asp Ala Met Glu Tyr Ser Ser Glu Glu Glu Glu Val Asp Leu Gln 
     290                295                300
Thr Ala Leu Thr Gly Tyr Gln Thr Lys Gln Arg Lys Leu Leu Glu Pro 
 305                310                315                320
Val Asp His Gly Lys Ile Glu Tyr Glu Pro Phe Arg Lys Asn Phe Tyr 
                 325                330                335
Val Glu Val Pro Glu Leu Ala Lys Met Ser Gln Glu Glu Val Asn Val 
             340                345                350
Phe Arg Leu Glu Met Glu Gly Ile Thr Val Lys Gly Lys Gly Cys Pro 
         355                360                365
Lys Pro Ile Lys Ser Trp Val Gln Cys Gly Ile Ser Met Lys Ile Leu 
     370                375                380
Asn Ser Leu Lys Lys His Gly Tyr Glu Lys Pro Thr Pro Ile Gln Thr 
 385                390                395                400
Gln Ala Ile Pro Ala Ile Met Ser Gly Arg Asp Leu Ile Gly Ile Ala 
                 405                410                415
Lys Thr Gly Ser Gly Lys Thr Ile Ala Phe Leu Leu Pro Met Phe Arg 
             420                425                430
His Ile Met Asp Gln Arg Ser Leu Glu Glu Gly Glu Gly Pro Ile Ala 
         435                440                445
Val Ile Met Thr Pro Thr Arg Glu Leu Ala Leu Gln Ile Thr Lys Glu 
     450                455                460
Cys Lys Lys Phe Ser Lys Thr Leu Gly Leu Arg Val Val Cys Val Tyr 
 465                470                475                480
Gly Gly Thr Gly Ile Ser Glu Gln Ile Ala Glu Leu Lys Arg Gly Ala 
                 485                490                495
Glu Ile Ile Val Cys Thr Pro Gly Arg Met Ile Asp Met Leu Ala Ala 
             500                505                510
Asn Ser Gly Arg Val Thr Asn Leu Arg Arg Val Thr Tyr Val Val Leu 
         515                520                525
Asp Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Pro Gln Val Met 
     530                535                540
Arg Ile Val Asp Asn Val Arg Pro Asp Arg Gln Thr Val Met Phe Ser 
 545                550                555                560
Ala Thr Phe Pro Arg Ala Met Glu Ala Leu Ala Arg Arg Ile Leu Ser 
                 565                570                575
Lys Pro Ile Glu Val Gln Val Gly Gly Arg Ser Val Val Cys Ser Asp 
             580                585                590
Val Glu Gln Gln Val Ile Val Ile Glu Glu Glu Lys Lys Phe Leu Lys 
         595                600                605
Leu Leu Glu Leu Leu Gly His Tyr Gln Glu Ser Gly Ser Val Ile Ile 
     610                615                620
Phe Val Asp Lys Gln Glu His Ala Asp Gly Leu Leu Lys Asp Leu Met 
 625                630                635                640
Arg Ala Ser Tyr Pro Cys Met Ser Leu His Gly Gly Ile Asp Gln Tyr 
                 645                650                655
Asp Arg Asp Ser Ile Ile Asn Asp Phe Lys Asn Gly Thr Cys Lys Leu 
             660                665                670
Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Val Lys His Leu 
         675                680                685
Ile Leu Val Val Asn Tyr Ser Cys Pro Asn His Tyr Glu Asp Tyr Val 
     690                695                700
His Arg Ala Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Tyr Ala Tyr 
 705                710                715                720
Thr Phe Ile Thr Glu Asp Gln Ala Arg Tyr Ala Gly Asp Ile Ile Lys 
                 725                730                735
Ala Leu Glu Leu Ser Gly Thr Ala Val Pro Pro Asp Leu Glu Lys Leu 
             740                745                750
Trp Ser Asp Phe Lys Asp Gln Gln Lys Ala Glu Gly Lys Ile Ile Lys 
         755                760                765
Lys Ser Ser Gly Phe Ser Gly Lys Gly Phe Lys Phe Asp Glu Thr Glu 
     770                775                780
Gln Ala Leu Ala Asn Glu Arg Lys Lys Leu Gln Lys Ala Ala Leu Gly 
 785                790                795                800
Leu Gln Asp Ser Asp Asp Glu Asp Ala Ala Val Asp Ile Asp Glu Gln 
                 805                810                815
Ile Glu Ser Met Phe Asn Ser Lys Lys Arg Val Lys Asp Met Ala Ala 
             820                825                830
Pro Gly Thr Ser Ser Val Pro Ala Pro Thr Ala Gly Asn Ala Glu Lys 
         835                840                845
Leu Glu Ile Ala Lys Arg Leu Ala Leu Arg Ile Asn Ala Gln Lys Asn 
     850                855                860
Leu Gly Ile Glu Ser Gln Val Asp Val Met Gln Gln Ala Thr Asn Ala 
 865                870                875                880
Ile Leu Arg Gly Gly Thr Ile Leu Ala Pro Thr Val Ser Ala Lys Thr 
                 885                890                895
Ile Ala Glu Gln Leu Ala Glu Lys Ile Asn Ala Lys Leu Asn Tyr Val 
             900                905                910
Pro Leu Glu Lys Gln Glu Glu Glu Arg Gln Asp Gly Gly Gln Asn Glu 
         915                920                925
Ser Phe Lys Arg Tyr Glu Glu Glu Leu Glu Ile Asn Asp Phe Pro Gln 
     930                935                940
Thr Ala Arg Trp Lys Val Thr Ser Lys Glu Ala Leu Gln Arg Ile Ser 
 945                950                955                960
Glu Tyr Ser Glu Ala Ala Ile Thr Ile Arg Gly Thr Tyr Phe Pro Pro 
                 965                970                975
Gly Lys Glu Pro Lys Glu Gly Glu Arg Lys Ile Tyr Leu Ala Ile Glu 
             980                985                990
Ser Ala Asn Glu Leu Ala Val Gln Lys Ala Lys Ala Glu Ile Thr Arg 
         995                1000                1005
Leu Ile Lys Glu Glu Leu Ile Arg Leu Gln Asn Ser Tyr Gln Pro Thr 
     1010                1015                1020
Asn Lys Gly Arg Tyr Lys Val Leu 
 1025                1030



<210> 8293
<211> 3531
<212> DNA
<213> Rattus norvegicus
<308> U25746
<400> 8293

cacgctctg  tggcggtca  tgctggagc  ttggccatt  cgtagggcc  gtcctcgct  60
ggtactgtg  ggacttggt  cctccctcc  ttgtcctct  caccggtct  cgcatcgtc  120
ccaagggcg  aggccttcc  ctggctggc  gcatgggca  ggagtctcg  cattaccga  180
aacggtcag  atctcgagg  cgctctgga  gtcggtcta  gagtcgctc  ccctctgac  240
aaagaagca  acgtggaga  gacaggcgt  ccaggagta  agacagaga  agaaggaga  300
agaggtctc  gagcaggga  aaaaggaga  ctcggtcac  ggacaggaa  cgcctgaga  360
gttccagaa  tagagagcg  gacagaagc  gagagcgaa  aagatctcg  agccgggat  420
gaaggcgct  aaggagtcg  agccggggc  ggcggtccc  gtcttccag  cctggcagc  480
aaagcaaga  ggctgagaa  aggtctagg  ccaaagaga  agcagaagg  ggggacagc  540
ccaaggaga  gaagaaaga  aaggacgac  aggaggacg  gaaagagaa  gatgctggg  600
attttgacc  gaataagct  gaagaagaa  tgagaaaac  aaaagaaag  gttgaaaaa  660
ggcgagaag  gcagcgtaa  aaggcgatg  agaacatag  ggagctgaa  aaggagatc  720
aggagatga  gcaggggaa  aagtggagc  tggaagatg  cgacgatga  gaagatgac  780
ctgccgagg  tgagaagga  gggaatgaa  tggaggacg  ggagctgga  ccattagat  840
cctacatgg  ggaagtgaa  gaagaggta  aaaagttta  catgaggag  gtgaaaggc  900
gcgcaggaa  tgagaagaa  tccggaccg  ctgtcacga  agtggttac  gtggtaaca  960
ccaagaaag  agtagtaga  gccgacaag  agaagggag  gctgatgga  aatgaccag  1020
acgccatgg  gtactcctc  gaggaggaa  aggttgacc  tcagacggc  ctcacaggc  1080
accagacaa  acagagaaa  cttctagag  cagtggatc  tgggaaaat  gagtatgag  1140
cattcagaa  aaactttta  gttgaagtt  cagaattag  gaaaatgtc  caagaagag  1200
tgaatgtgt  tcggttgga  atggagggc  ttacagtta  aggaaaagg  tgccccaag  1260
caattaaat  atgggtcca  tgtggaatt  ccatgaaga  actgaattc  ctcaaaaag  1320
atggctatg  aaagcccac  ccaatccaa  ctcaagcaa  tcctgctat  atgtctgga  1380
gagatttga  tggcattgc  aagacagga  gtggaaaaa  cattgcttt  cttttgccc  1440
tgtttagac  catcatgga  cagaggtca  tggaagaag  agagggacc  atcgctgtc  1500
tcatgactc  aactcgaga  ctggcttta  aaatcacta  agaatgtaa  aagttttcg  1560
agaccttgg  actgagagt  gtctgtgtg  atggaggga  aggaatcag  gagcagatt  1620
ctgagctga  gagaggcgc  gagatcatt  tttgcacac  tggccggat  atcgacatg  1680
tggcagcta  cagtggtcg  gtcacaaat  ttcgaagag  gacatatgt  gttttagat  1740
aagcagaca  aatgtttga  atgggtttt  aaccacagg  catgcgcat  gtggacaat  1800
tccgtcctg  ccgacagac  gttatgttc  cagctactt  cccaagagc  atggaagcg  1860
tggcccgca  gatcttgag  aagcccatt  aagttcagg  tggaggccg  agtgtggtt  1920
gctcagatg  ggaacaaca  gtgattgtg  ttgaagaag  gaagaaatt  ttgaaattg  1980
tggagcttt  aggccatta  caggagtca  gatctgtca  tatatttgt  gataagcag  2040
aacacgctg  tggtcttct  aaggacttg  tgagagctt  ctacccttg  atgtctctt  2100
acggaggta  tgatcagta  gacagggac  gtatcataa  tgactttaa  aatggaacc  2160
gcaaacttc  cgtagccac  tctgttgcc  cccgtggtc  agatgtgaa  catctcatt  2220
ttgtagtaa  ttacagctg  cccaatcat  acgaagatt  cgtgcacag  gctgggcgg  2280
ctggaagag  aggcaacaa  ggttatgcc  acaccttca  cacagaaga  caagctcga  2340
atgctgggg  catcattaa  gctcttgaa  tgtcgggga  ggcggtgcc  cctgaccta  2400
agaaactat  gagtgactt  aaagatcag  agaaagctg  aggaaaaat  attaaaaag  2460
gcagcggct  ctctggcaa  gggttcaag  ttgatgaga  agagcaggc  ttagccaat  2520
agaggaaaa  gctacaaaa  gctgccctt  gcctgcagg  ttctgatga  gaggacgcc  2580
cagttgata  tgacgagca  attgaaagc  tgtttaatt  caagaagag  gtgaaagac  2640
tggctgctc  cggcacatc  agtgcgcct  ctccgactg  gggcaatgc  gagaagcta  2700
agattgcca  gaggttggc  cttagaatc  acgctcaga  gaacctggg  atcgagtct  2760
aggtagatg  gatgcagca  gccacaaat  ccatcctca  aggtggccc  cttctggct  2820
ccaccgtgt  tgcaaaaac  atcgcagag  agcttgccg  gaagatcaa  gccaagctc  2880
attacgtgc  tttggagaa  caggaagaa  agagacagg  gggtgggca  agcgaatct  2940
tcaagagat  cgaggaaga  ttagaaatt  atgacttcc  acagacggc  aggtggaaa  3000
ttacctcta  ggaagcctt  cagaggatc  gtgagtact  ggaagccgc  atcacaatc  3060
gagggacct  cttcccgcc  ggcaaagag  ccaaggaag  agagcggaa  atctacttg  3120
cgattgaaa  tgccaacga  ctggctgtg  agaaagcaa  ggcagagat  accaggctc  3180
taaaagagg  gctgatccg  ctgcaaaat  cataccaac  caccaacaa  ggacgatac  3240
aagtattat  aacaccgga  ccactttgt  cccgtgcta  ctgtgacgt  tacagtgta  3300
tgtaaagta  gacttttaa  attctgtct  gcttatttt  taagtacaa  aaaccagtg  3360
ttgttcaag  ggtcatctg  aagtactac  ctataccca  ccaaactcc  tttaaatca  3420
agctgtttt  agagtgtga  gttcttcga  gtaaacctt  gataccaac  ctttaaata  3480
ctggagaca  tgggatttt  tactgaatg  agtaataaa  tgtgtcagg  a  3531



<210> 8294
<211> 1033
<212> PRT
<213> Rattus norvegicus
<308> U25746
<400> 8294

Met Gly Arg Glu Ser Arg His Tyr Arg Lys Arg Ser Ala Ser Arg Gly 
  1               5                  10                  15
Arg Ser Gly Ser Arg Ser Arg Ser Arg Ser Pro Ser Asp Lys Arg Ser 
             20                  25                  30
Lys Arg Gly Asp Asp Arg Arg Ser Arg Ser Arg Asp Arg Asp Arg Arg 
         35                  40                  45
Arg Glu Arg Ser Arg Ser Arg Asp Lys Arg Arg Ser Arg Ser Arg Asp 
     50                  55                  60
Arg Lys Arg Leu Arg Arg Ser Arg Ser Arg Glu Arg Asp Arg Ser Arg 
 65                  70                  75                  80
Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser Arg 
                 85                  90                  95
Ser Arg Gly Arg Arg Ser Arg Ser Ser Ser Pro Gly Ser Lys Ser Lys 
             100                105                110
Lys Ala Glu Asn Arg Ser Arg Ser Lys Glu Lys Ala Glu Gly Gly Asp 
         115                120                125
Ser Ser Lys Glu Lys Lys Lys Asp Lys Asp Asp Lys Glu Asp Glu Lys 
     130                135                140
Glu Lys Asp Ala Gly Asn Phe Asp Gln Asn Lys Leu Glu Glu Glu Met 
 145                150                155                160
Arg Lys Arg Lys Glu Arg Val Glu Lys Trp Arg Glu Glu Gln Arg Lys 
                 165                170                175
Lys Ala Met Glu Asn Ile Gly Glu Leu Lys Lys Glu Ile Glu Glu Met 
             180                185                190
Lys Gln Gly Lys Lys Trp Ser Leu Glu Asp Asp Asp Asp Asp Glu Asp 
         195                200                205
Asp Pro Ala Glu Ala Glu Lys Glu Gly Asn Glu Met Glu Asp Glu Glu 
     210                215                220
Leu Asp Pro Leu Asp Ala Tyr Met Glu Glu Val Lys Glu Glu Val Lys 
 225                230                235                240
Lys Phe Asn Met Arg Ser Val Lys Gly Gly Ala Gly Asn Glu Lys Lys 
                 245                250                255
Ser Gly Pro Thr Val Thr Lys Val Val Thr Val Val Thr Thr Lys Lys 
             260                265                270
Ala Val Val Asp Ala Asp Lys Lys Lys Gly Glu Leu Met Glu Asn Asp 
         275                280                285
Gln Asp Ala Met Glu Tyr Ser Ser Glu Glu Glu Glu Val Asp Leu Gln 
     290                295                300
Thr Ala Leu Thr Gly Tyr Gln Thr Lys Gln Arg Lys Leu Leu Glu Pro 
 305                310                315                320
Val Asp His Gly Lys Ile Glu Tyr Glu Pro Phe Arg Lys Asn Phe Tyr 
                 325                330                335
Val Glu Val Pro Glu Leu Ala Lys Met Ser Gln Glu Glu Val Asn Val 
             340                345                350
Phe Arg Leu Glu Met Glu Gly Ile Thr Val Lys Gly Lys Gly Cys Pro 
         355                360                365
Lys Pro Ile Lys Ser Trp Val Gln Cys Gly Ile Ser Met Lys Ile Leu 
     370                375                380
Asn Ser Leu Lys Lys His Gly Tyr Glu Lys Pro Thr Pro Ile Gln Thr 
 385                390                395                400
Gln Ala Ile Pro Ala Ile Met Ser Gly Arg Asp Leu Ile Gly Ile Ala 
                 405                410                415
Lys Thr Gly Ser Gly Lys Thr Ile Ala Phe Leu Leu Pro Met Phe Arg 
             420                425                430
His Ile Met Asp Gln Arg Ser Leu Glu Glu Gly Glu Gly Pro Ile Ala 
         435                440                445
Val Ile Met Thr Pro Thr Arg Glu Leu Ala Leu Gln Ile Thr Lys Glu 
     450                455                460
Cys Lys Lys Phe Ser Lys Thr Leu Gly Leu Arg Val Val Cys Val Tyr 
 465                470                475                480
Gly Gly Thr Gly Ile Ser Glu Gln Ile Ala Glu Leu Lys Arg Gly Ala 
                 485                490                495
Glu Ile Ile Val Cys Thr Pro Gly Arg Met Ile Asp Met Leu Ala Ala 
             500                505                510
Asn Ser Gly Arg Val Thr Asn Leu Arg Arg Val Thr Tyr Val Val Leu 
         515                520                525
Asp Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Pro Gln Val Met 
     530                535                540
Arg Ile Val Asp Asn Val Arg Pro Asp Arg Gln Thr Val Met Phe Ser 
 545                550                555                560
Ala Thr Phe Pro Arg Ala Met Glu Ala Leu Ala Arg Arg Ile Leu Ser 
                 565                570                575
Lys Pro Ile Glu Val Gln Val Gly Gly Arg Ser Val Val Cys Ser Asp 
             580                585                590
Val Glu Gln Gln Val Ile Val Ile Glu Glu Glu Lys Lys Phe Leu Lys 
         595                600                605
Leu Leu Glu Leu Leu Gly His Tyr Gln Glu Ser Gly Ser Val Ile Ile 
     610                615                620
Phe Val Asp Lys Gln Glu His Ala Asp Gly Leu Leu Lys Asp Leu Met 
 625                630                635                640
Arg Ala Ser Tyr Pro Cys Met Ser Leu His Gly Gly Ile Asp Gln Tyr 
                 645                650                655
Asp Arg Asp Ser Ile Ile Asn Asp Phe Lys Asn Gly Thr Cys Lys Leu 
             660                665                670
Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Val Lys His Leu 
         675                680                685
Ile Leu Val Val Asn Tyr Ser Cys Pro Asn His Tyr Glu Asp Tyr Val 
     690                695                700
His Arg Ala Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Tyr Ala Tyr 
 705                710                715                720
Thr Phe Ile Thr Glu Asp Gln Ala Arg Tyr Ala Gly Asp Ile Ile Lys 
                 725                730                735
Ala Leu Glu Leu Ser Gly Thr Ala Val Pro Pro Asp Leu Glu Lys Leu 
             740                745                750
Trp Ser Asp Phe Lys Asp Gln Gln Lys Ala Glu Gly Lys Ile Ile Lys 
         755                760                765
Lys Ser Ser Gly Phe Ser Gly Lys Gly Phe Lys Phe Asp Glu Thr Glu 
     770                775                780
Gln Ala Leu Ala Asn Glu Arg Lys Lys Leu Gln Lys Ala Ala Leu Gly 
 785                790                795                800
Leu Gln Asp Ser Asp Asp Glu Asp Ala Ala Val Asp Ile Asp Glu Gln 
                 805                810                815
Ile Glu Ser Met Phe Asn Ser Lys Lys Arg Val Lys Asp Met Ala Ala 
             820                825                830
Pro Gly Thr Ser Ser Ala Pro Ala Pro Thr Ala Gly Asn Ala Glu Lys 
         835                840                845
Leu Glu Ile Ala Lys Arg Leu Ala Leu Arg Ile Asn Ala Gln Lys Asn 
     850                855                860
Leu Gly Ile Glu Ser Gln Val Asp Val Met Gln Gln Ala Thr Asn Ala 
 865                870                875                880
Ile Leu Arg Gly Gly Pro Leu Leu Ala Pro Thr Val Ser Ala Lys Thr 
                 885                890                895
Ile Ala Glu Gln Leu Ala Glu Lys Ile Asn Ala Lys Leu Asn Tyr Val 
             900                905                910
Pro Leu Glu Lys Gln Glu Glu Glu Arg Gln Glu Gly Gly Gln Ser Glu 
         915                920                925
Ser Phe Lys Arg Tyr Glu Glu Glu Leu Glu Ile Asn Asp Phe Pro Gln 
     930                935                940
Thr Ala Arg Trp Lys Val Thr Ser Lys Glu Ala Leu Gln Arg Ile Ser 
 945                950                955                960
Glu Tyr Ser Glu Ala Ala Ile Thr Ile Arg Gly Thr Tyr Phe Pro Pro 
                 965                970                975
Gly Lys Glu Pro Lys Glu Gly Glu Arg Lys Ile Tyr Leu Ala Ile Glu 
             980                985                990
Ser Ala Asn Glu Leu Ala Val Gln Lys Ala Lys Ala Glu Ile Thr Arg 
         995                1000                1005
Leu Ile Lys Glu Glu Leu Ile Arg Leu Gln Asn Ser Tyr Gln Pro Thr 
     1010                1015                1020
Asn Lys Gly Arg Tyr Lys Val Leu Ter 
 1025                1030



<210> 8295
<211> 3746
<212> DNA
<213> Homo sapiens
<308> AF106680
<400> 8295

cccgcgctg  gatggccgc  acagctgta  gtgctgcta  tgtttagcg  tggtctttg  60
cgggcgttg  gggcagctc  gcctccttg  ttgtccggt  cgcctgtgc  tggtactca  120
gggcaccag  attcccgcg  tcggcagca  gggtcggga  tcacgccac  atcgaaaac  180
atcggcatc  cggggtcgc  ctggaagtc  gtctagaag  cgctcaccc  cagacaaaa  240
aagtaaacg  ggagatgac  gacggtcta  aagtagaga  agagatagg  ggagagaga  300
gtctcgtag  agggataaa  gaagatctc  gtcaaggga  aggaagcgt  tgagacgtt  360
cagaagtag  gagagagac  gaagccgag  gcgaagaag  tctcgaagt  gagacagga  420
acgctcaag  agtagaagc  ggggccggc  atcccgatc  tccagtcct  gcagcaaaa  480
caagaaggc  gagaacagg  ctaggtcca  agagaaagc  gaaggtggg  acagctcca  540
ggagaagaa  aaagacaag  acgacaagg  ggacgagaa  gagaaggat  ctgggaatt  600
tgaccagaa  aagctggaa  aagaaatga  aaaacgaaa  gaaagggtt  aaaaatggc  660
agaagagca  cgtaaaaag  cgatggaga  catagggga  ctgaagaag  agatcgagg  720
gatgaagca  gggaagaag  ggagcctgg  agatgacga  gatgatgaa  atgaccctg  780
cgaggctga  aaggaaggg  atgaaatgg  ggacgagga  ctggaccca  tagatgcct  840
catggagga  gtgaaagaa  aggtaaaaa  gtttaacat  aggagcgtg  aaggcggcg  900
aggaaatga  aagaagtcc  ggccaacgg  cacaaaagt  gtcactgtt  tgacaacca  960
aaaagcagt  gtggattct  ataagaaga  aggtgagct  atggagaat  accaggatg  1020
catggagta  tcttcagag  aggaagaag  tgatcttca  acagccctt  cagggtatc  1080
aacaaaaca  cgaaaactt  tagaaccag  tgatcatgg  aaaattgag  atgagccat  1140
taggaaaaa  ttctatgtt  aagttccag  actagcaaa  atgtctcaa  aagaggtaa  1200
tgtgtttcg  ttggaaatg  agggcatta  agttaaagg  aaaggttgc  ccaaaccaa  1260
taaatcctg  gtccagtgt  gaatttcca  gaagatctt  aattccctc  agaagcatg  1320
ctatgaaaa  cccacgccc  tccaaaccc  agctattcc  gctataatg  ctggacgag  1380
tttgattgg  attgccaaa  caggaagtg  aaagaccat  gcttttctg  tgcccatgt  1440
tagacacat  atggatcag  ggtcattag  ggaaggaga  gggccatta  ctgtcatca  1500
gactcccac  cgagaactg  ctttacaga  acctaaggg  gtaagaagt  tcaagactt  1560
gggacttag  gtggtctgt  tttacggag  aacaggaat  agtgagcag  ttgctgagc  1620
gaaaagagg  gctgaaatt  ttgtttgca  acctggtcg  atgattgac  tgttagccg  1680
taacagtgg  cgggtcaca  atcttcgaa  agtgacata  gttgtttta  atgaagcag  1740
cagaatgtt  gacatgggt  ttgaacccc  ggtcatgcg  atcgtggat  atgttcgtc  1800
tgatcgaca  acggttatg  tttcagcta  tttcccaag  gctatggaa  cgttggccc  1860
caggatctt  agcaagccc  ttgaagttc  ggttggagg  cggagtgtg  tttgctcag  1920
tgtggaaca  caagtgatt  tgattgaag  agagaagaa  ttcttgaaa  tgctggagc  1980
tttaggcca  tatcaggag  caggatctg  cattatatt  gtggataag  aggaacacg  2040
tgatggtct  ctgaaggat  taatgagag  atcttatcc  tgcatgtct  ttcatggag  2100
cattgatca  tatgacaga  atagcatca  aaatgactt  aagaatggg  cctgcaaac  2160
tcttgtggc  acctctgtt  ctgcccgag  tctagatgt  aaacatctg  ttcttgtag  2220
aaattatag  tgccccaac  attatgagg  ttatgtaca  agagcaggg  ggactggaa  2280
agcaggaaa  aagggttat  cttatactt  tatcacaga  gatcaagct  gctatgctg  2340
tgacataat  aaagctctt  aattgtcgg  gactgcggt  cctcctgac  tagagaaac  2400
atggagtga  ttcaaagat  agcagaaag  tgaaggaaa  ataattaaa  agagcagcg  2460
cttctctgg  aaggggttc  agtttgatg  gacagagca  gctttagcc  atgagagga  2520
aaagctaca  aaagctgcc  ttggcctgc  agattcaga  gatgaggat  ctgcagttg  2580
tattgatga  caaattgaa  gcatgttta  ttcaaagaa  agagtaaag  atatggctg  2640
tcctggaac  tcaagtgtt  ctgctccaa  tgcaggaaa  gctgagaaa  tagaaattg  2700
taagagatt  gctcttaga  tcaatgccc  gaagaattt  ggcatcgag  ctcaggtag  2760
tgtgatgca  caggccacc  atgcaattc  taggggtgg  accattctg  ctcccactg  2820
ttctgcaaa  accattgca  aacaacttg  tgaaaagat  aatgccaag  tcaattatg  2880
gccgttaga  aaacaagaa  aagagagac  ggatggtgg  cagaatgaa  cttttaaga  2940
atatgaaga  gaattagag  tcaatgact  cccacagac  gctaggtgg  aagttacct  3000
taaggaagc  ctgcagaga  tcagtgaat  ctctgaagc  gcaattaca  tcagaggaa  3060
ctacttccc  cctggcaaa  aacccaagg  aggcgagcg  aagatttac  tggcaattg  3120
aagtgccaa  gaactggct  tgcagaaag  aaaggcaga  atcaccagg  tcataaaag  3180
agagctgat  cggctgcaa  attcatacc  accaacaaa  aaaggaaga  acaaagtct  3240
atagacatc  ggaaaaaag  tttttacct  tgctggtct  tgatgtatg  ggcagttgc  3300
gtctgcagt  tacaatgta  tgtaaatga  gatttttta  attctatct  gctgatttt  3360
tttaaatat  agaaactgg  acttggtaa  gaaatctgt  cgtaagtac  cccacaatc  3420
gtcaaacta  atttaaagc  agcctgttt  cagagtatg  tgtccttta  tgtaaactc  3480
aatatcaat  ttttaaatg  ccggataat  ttctagagg  ttaaaaaat  gaaatattt  3540
aactttcta  tgaagacaa  aaagtacac  agtcgttaa  gggctattc  ctttatcct  3600
tactttcaa  gaaattgtg  tcatttcct  agaaaaggt  aaattcact  tcatatttt  3660
tgtccccac  ttgatgtta  atgactctg  aacaatatg  actggattt  agaatgtta  3720
aatagaagt  ttacaaaat  gaaaaa  3746



<210> 8296
<211> 1032
<212> PRT
<213> Homo sapiens
<308> BAA34521
<400> 8296

Met Gly Arg Glu Ser Arg His Tyr Arg Lys Arg Ser Ala Ser Arg Gly 
  1               5                  10                  15
Arg Ser Gly Ser Arg Ser Arg Ser Arg Ser Pro Ser Asp Lys Arg Ser 
             20                  25                  30
Lys Arg Gly Asp Asp Arg Arg Ser Arg Ser Arg Asp Arg Asp Arg Arg 
         35                  40                  45
Arg Glu Arg Ser Arg Ser Arg Asp Lys Arg Arg Ser Arg Ser Arg Asp 
     50                  55                  60
Arg Lys Arg Leu Arg Arg Ser Arg Ser Arg Glu Arg Asp Arg Ser Arg 
 65                  70                  75                  80
Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser Arg 
                 85                  90                  95
Ser Arg Gly Arg Arg Ser Arg Ser Ser Ser Pro Gly Asn Lys Ser Lys 
             100                105                110
Lys Thr Glu Asn Arg Ser Arg Ser Lys Glu Lys Thr Asp Gly Gly Glu 
         115                120                125
Ser Ser Lys Glu Lys Lys Lys Asp Lys Asp Asp Lys Glu Asp Glu Lys 
     130                135                140
Glu Lys Asp Ala Gly Asn Phe Asp Gln Asn Lys Leu Glu Glu Glu Met 
 145                150                155                160
Arg Lys Arg Lys Glu Arg Val Glu Lys Trp Arg Glu Glu Gln Arg Lys 
                 165                170                175
Lys Ala Met Glu Asn Ile Gly Glu Leu Lys Lys Glu Ile Glu Glu Met 
             180                185                190
Lys Gln Gly Lys Lys Trp Ser Leu Glu Asp Asp Asp Asp Asp Glu Asp 
         195                200                205
Asp Pro Ala Glu Ala Glu Lys Glu Gly Asn Glu Met Glu Gly Glu Glu 
     210                215                220
Leu Asp Pro Leu Asp Ala Tyr Met Glu Glu Val Lys Glu Glu Val Lys 
 225                230                235                240
Lys Phe Asn Met Arg Ser Val Lys Gly Gly Gly Gly Asn Glu Lys Lys 
                 245                250                255
Ser Gly Pro Thr Val Thr Lys Val Val Thr Val Val Thr Thr Lys Lys 
             260                265                270
Ala Val Val Asp Ser Asp Lys Lys Lys Gly Glu Leu Met Glu Asn Asp 
         275                280                285
Gln Asp Ala Met Glu Tyr Ser Ser Glu Glu Glu Glu Val Asp Leu Gln 
     290                295                300
Thr Ala Leu Thr Gly Tyr Gln Thr Lys Gln Arg Lys Leu Leu Glu Pro 
 305                310                315                320
Val Asp His Gly Lys Ile Glu Tyr Glu Pro Phe Arg Lys Asn Phe Tyr 
                 325                330                335
Val Glu Val Pro Glu Leu Ala Lys Met Ser Gln Glu Glu Val Asn Val 
             340                345                350
Phe Arg Leu Glu Met Glu Gly Ile Thr Val Lys Gly Lys Gly Cys Pro 
         355                360                365
Lys Pro Ile Lys Ser Trp Val Gln Cys Gly Ile Ser Met Lys Ile Leu 
     370                375                380
Asn Ser Leu Lys Lys His Gly Tyr Glu Lys Pro Thr Pro Ile Gln Thr 
 385                390                395                400
Gln Ala Ile Pro Ala Ile Met Ser Gly Arg Asp Leu Ile Gly Ile Ala 
                 405                410                415
Lys Thr Gly Ser Gly Lys Thr Ile Ala Phe Leu Leu Pro Met Phe Arg 
             420                425                430
His Ile Met Asp Gln Arg Ser Leu Glu Glu Gly Glu Gly Pro Ile Ala 
         435                440                445
Val Ile Met Thr Pro Thr Arg Glu Leu Ala Leu Gln Ile Thr Lys Glu 
     450                455                460
Cys Lys Lys Phe Ser Lys Thr Leu Gly Leu Arg Val Val Cys Val Tyr 
 465                470                475                480
Gly Gly Thr Gly Ile Ser Glu Gln Ile Ala Glu Leu Lys Arg Gly Ala 
                 485                490                495
Glu Ile Ile Val Cys Thr Pro Gly Arg Met Ile Asp Met Leu Ala Ala 
             500                505                510
Asn Ser Gly Arg Val Thr Asn Leu Arg Arg Val Thr Tyr Val Val Leu 
         515                520                525
Asp Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Pro Gln Val Met 
     530                535                540
Arg Ile Val Asp Asn Val Arg Pro Asp Arg Gln Thr Val Met Phe Ser 
 545                550                555                560
Ala Thr Phe Pro Arg Ala Met Glu Ala Leu Ala Arg Arg Ile Leu Ser 
                 565                570                575
Lys Pro Ile Glu Val Gln Val Gly Gly Arg Ser Val Val Cys Ser Asp 
             580                585                590
Val Glu Gln Gln Val Ile Val Ile Glu Glu Glu Lys Lys Phe Leu Lys 
         595                600                605
Leu Leu Glu Leu Leu Gly His Tyr Gln Glu Ser Gly Ser Val Ile Ile 
     610                615                620
Phe Val Asp Lys Gln Glu His Ala Asp Gly Leu Leu Lys Asp Leu Met 
 625                630                635                640
Arg Ala Ser Tyr Pro Cys Met Ser Leu His Gly Gly Ile Asp Gln Tyr 
                 645                650                655
Asp Arg Asp Ser Ile Ile Asn Asp Phe Lys Asn Gly Thr Cys Lys Leu 
             660                665                670
Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Val Lys His Leu 
         675                680                685
Ile Leu Val Val Asn Tyr Ser Cys Pro Asn His Tyr Glu Asp Tyr Val 
     690                695                700
His Arg Ala Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Tyr Ala Tyr 
 705                710                715                720
Thr Phe Ile Thr Glu Asp Gln Ala Arg Tyr Ala Gly Asp Ile Ile Lys 
                 725                730                735
Ala Leu Glu Leu Ser Gly Thr Ala Val Pro Pro Asp Leu Glu Lys Leu 
             740                745                750
Trp Ser Asp Phe Lys Asp Gln Gln Lys Ala Glu Gly Lys Ile Ile Lys 
         755                760                765
Lys Ser Ser Gly Phe Ser Gly Lys Gly Phe Lys Phe Asp Glu Thr Glu 
     770                775                780
Gln Ala Leu Ala Asn Glu Arg Lys Lys Leu Gln Lys Ala Ala Leu Gly 
 785                790                795                800
Leu Gln Asp Ser Asp Asp Glu Asp Ala Ala Val Asp Ile Asp Glu Gln 
                 805                810                815
Ile Glu Ser Met Phe Asn Ser Lys Lys Arg Val Lys Asp Met Ala Ala 
             820                825                830
Pro Gly Thr Ser Ser Val Pro Ala Pro Thr Ala Gly Asn Ala Glu Lys 
         835                840                845
Leu Glu Ile Ala Lys Arg Leu Ala Leu Arg Ile Asn Ala Gln Lys Asn 
     850                855                860
Leu Gly Ile Glu Ser Gln Val Asp Val Met Gln Gln Ala Thr Asn Ala 
 865                870                875                880
Ile Leu Arg Gly Gly Thr Ile Leu Ala Pro Thr Val Ser Ala Lys Thr 
                 885                890                895
Ile Ala Glu Gln Leu Ala Glu Lys Ile Asn Ala Lys Leu Asn Tyr Val 
             900                905                910
Pro Leu Glu Lys Gln Glu Glu Glu Arg Gln Asp Gly Gly Gln Asn Glu 
         915                920                925
Ser Phe Lys Arg Tyr Glu Glu Glu Leu Glu Ile Asn Asp Phe Pro Gln 
     930                935                940
Thr Ala Arg Trp Lys Val Thr Ser Lys Glu Ala Leu Gln Arg Ile Ser 
 945                950                955                960
Glu Tyr Ser Glu Ala Ala Ile Thr Ile Arg Gly Thr Tyr Phe Pro Pro 
                 965                970                975
Gly Lys Glu Pro Lys Glu Gly Glu Arg Lys Ile Tyr Leu Ala Ile Glu 
             980                985                990
Ser Ala Asn Glu Leu Ala Val Gln Lys Ala Lys Ala Glu Ile Thr Arg 
         995                1000                1005
Leu Ile Lys Glu Glu Leu Ile Arg Leu Gln Asn Ser Tyr Gln Pro Thr 
     1010                1015                1020
Asn Lys Gly Arg Tyr Lys Val Leu 
 1025                1030



<210> 8297
<211> 643
<212> DNA
<213> Rattus norvegicus
<308> U26310
<400> 8297

aacccccat  ctagctgcc  ccattgttc  cttcaaggt  tctgcccaa  gaatcacac  60
gactgacaa  caaagaaag  tcttcttca  acgacatta  cccctcaac  ctgtcacct  120
ctgtgacct  gatccacaa  aaaggaagt  gatgaagac  gagggaggt  cccctgcta  180
gctcttcgg  ttcgtggcc  ggaagcagg  cagcaccac  gacaacgct  gccacctct  240
cgcagagct  gaccccaac  agcctgcgt  tgccattgt  aacttcgtc  ccaaggtca  300
gctgagtgc  ggccaaaag  gatgaacga  tcctggagc  cttgcccaa  gctggggca  360
tggggacgg  gtgtgtggg  agggatctg  gaatcctga  caccttgaa  ccagaacga  420
ggctttggg  cgaccgtgg  gaaggagag  agaaagtgc  atgctggga  agggaagtg  480
attgtggag  gagggaggg  aacaggagg  agaggaagg  aggaagaag  gaggaactc  540
aaatcccct  tacagatgg  agccacacc  cccaaagcc  ctccagcta  ctggggccc  600
tccccctca  ctcccaaag  ctctccagc  agcatgggg  ttc  643



<210> 8298
<211> 107
<212> PRT
<213> Rattus norvegicus
<308> AAA67648
<400> 8298

Thr Pro Met Leu Ala Ala Thr Ile Val His Phe Lys Val Ser Ala Gln 
  1               5                  10                  15
Gly Ile Thr Leu Thr Asp Asn Gln Arg Lys Leu Phe Phe Arg Arg His 
             20                  25                  30
Tyr Pro Leu Asn Thr Val Thr Phe Cys Asp Leu Asp Pro Gln Glu Arg 
         35                  40                  45
Lys Trp Met Lys Thr Glu Gly Gly Ala Pro Ala Lys Leu Phe Gly Phe 
     50                  55                  60
Val Ala Arg Lys Gln Gly Ser Thr Thr Asp Asn Ala Cys His Leu Phe 
 65                  70                  75                  80
Ala Glu Leu Asp Pro Asn Gln Pro Ala Ser Ala Ile Val Asn Phe Val 
                 85                  90                  95
Ser Lys Val Met Leu Ser Ala Gly Gln Lys Arg 
             100                105



<210> 8299
<211> 7267
<212> DNA
<213> Homo sapiens
<308> NM_022648
<400> 8299

ctgctcctt  caccccgct  cctgcctgg  cacaggctc  ctcgctgcc  tcttctggg  60
gaaaccagc  tcttgccag  cacagctgc  gcctccgcc  ctggccacc  cccctgtcc  120
gggagtccc  tggcccaga  acccacctg  cttagtggc  cctctgcag  aaaggtggc  180
gccccctgc  ttcctccat  caaccatga  ctggtgccc  tcaccactg  gaatgcacc  240
aagaatgta  tggacaagg  agaaggagc  tcccggggt  gaaacacac  gaaaagcct  300
gaggacaac  gctccacca  ggtcacccc  agtgtccag  cccacctcc  gcccatcag  360
aacatgagt  tgagccgga  catggagga  agctgtgag  tggacctgg  gtacgtcac  420
gagaggatc  tcgctgtct  cttccccag  acagccaat  aggagaact  ccggagcaa  480
ctccgtgag  tggcgcaga  gctcaagtc  aaacatgga  gcaactacc  gctgttcaa  540
ctctctgag  ggagacctg  catcacgaa  ctccatgcc  aggtactgg  atttggctg  600
cccgacctc  acaccccag  cctggagaa  atctgcagc  tctgtaagg  catggacac  660
tggctcaat  cagaccctc  caatgtcgt  gttctacac  acaagggaa  ccgaggcag  720
ataggagtt  tcatcgcgg  ttacatgca  tacagcaac  tttctgcca  tgcggacca  780
gctctggac  ggtttgcaa  gaagcggtt  tatgaggat  agattgtgc  cattggcca  840
ccatcccaa  gaaggtacg  gcattactt  agtggcctg  tctccggct  catcaaaat  900
aacaacaag  ccttgtttc  gcaccacgt  atcatgcac  gcatcccca  ctttgagtc  960
aaaggagga  gtcggccat  tctccgcat  taccaggcc  tgcaacctg  gtacacatc  1020
ggcatctac  acatcccag  agacagcca  actagcgtc  gcatcacca  cgagccagg  1080
ctgctcttg  agggagaca  cttgctgaa  tgctaccac  agaagttcc  aagcccagc  1140
cgagacgtc  tcttccgtg  gcagttcca  acctgtgcc  tccatgacc  gggggttgt  1200
tttgggaag  aggaccttg  tgatgcttt  aaagatgat  gatttccag  gtatggcaa  1260
gtggagttt  tattttctt  tgggccaga  aaaattcaa  gcatggagc  cctggagaa  1320
gggccgagc  tgtctgtgg  ctataacac  tctgacccc  tcatccgct  ggactccta  1380
gacaacttc  gtgggcatc  agatgacgg  atggaggag  tggtgggac  cacgcaggg  1440
ccactagat  ggagcctgt  tgctaaggt  aagaagaaa  actccctgc  cggcagcac  1500
ggggctgtt  atgccacac  tcctacact  tcggccacc  ccaaccacg  ggaacacac  1560
ctttctgtg  gcagcgact  gggcaactc  acagcctcc  ccaagaccg  caagaccga  1620
gagcctgtc  ccggggcct  cagtgccac  gctgccttg  gtccccagg  gaagcggga  1680
ctggaccgc  tgctgagtg  ctttggctt  gagcgagag  agcaaggcg  catgtacca  1740
acccagcac  tcaggtccc  cccagcagg  ggctcggct  tgccctcct  tggacgcca  1800
gttgtccca  cccaggttc  tgtcaatgg  ggggcgtta  catctgagc  ggagacaga  1860
atcctggac  atgaattgc  aaaccagga  ggtcacagt  cgggcagca  gggcacact  1920
tcttctctg  acggggtca  caacaccag  gaggggggc  acccagagg  cctgtcccc  1980
ctgaccaac  gtctggaca  gtcctaccc  atggagcct  tggtcaatg  aggaggcta  2040
ccctacgag  ctgccagcc  ggcggggcc  gcccatgct  gccacacgg  ccccatgcg  2100
ccctcctac  ctgcacagg  gggtttagc  ggctaccag  gggaggggc  ccacccagc  2160
tggccacag  cagtgacca  ctcccacta  gcccatgac  ccagcggta  gttccgctc  2220
caatccttt  cggaagctg  accccagct  cccccagct  cggtccgag  gggaagcag  2280
cgggaggct  tgcaaaggg  actgaattc  tggcagcag  agcagcagc  gcagcagca  2340
cctcgccca  ctccacgcc  gcaggaaag  gcccacttg  agagtcttg  agccagcag  2400
cccagccct  agccattgg  agagacccc  atccccagt  tccctgagt  cccgcgagc  2460
gcctcccag  aggagattg  acagtccat  gaaacactc  atatgctga  gctggacct  2520
gagccagcc  ccgctgctg  cccactaca  aagtcccag  gtgtccccg  ggcctggcc  2580
ggggcttct  cactctcct  ccagcccct  tctggatcc  cccgtcagt  ccatccact  2640
acccagtcc  gatctggct  tatccccag  gggcattcg  tgggaaccc  tgagccagc  2700
ccacgggcc  ctctggagt  tgtccctcc  ggcaggtct  actcacctt  tgactatca  2760
ccatgtttg  ctgggccta  ccaggattt  cattcaaag  gcccagcct  ttcctcctt  2820
cctgccttc  ttccgacca  ccacagccc  ccagggcct  agcaacccc  agcctctct  2880
cctggcctc  ctgctcagc  tctgctctc  ccaaaggaa  cgacttcag  cccctcccg  2940
actccagag  aggagccat  gaatttaga  gggctggtg  cccacaggg  agcaggggt  3000
caggctcgg  agaagcagc  tgcagagcc  ccagcccct  tgcggaggc  ggcggccag  3060
gatggacag  atgagaacc  gtctccaga  gccacatcc  ctcgtagcc  tggggttcg  3120
tcccctgtc  agtgtgtct  cccggagct  gctcttacc  tcgctctca  tcctggagg  3180
cggcccaaa  agccccatt  gcacagcta  aaggaggcc  tcgaggaga  ggagggaac  3240
tccccgagc  gcccaccac  cagtggggt  cggtccccc  cgggtctgg  caagacacc  3300
ctgtctgct  tgggcctga  acctcacaa  ccagcggac  tcctgttgc  ccccacagg  3360
gttaccaga  gacggatcc  gccagagga  gatgagggg  aggtggtgg  caggctgtc  3420
gaagagccc  ggagctatg  ggagtctgt  gcacggaca  cggtggctg  accccgagc  3480
caggactct  agcccaaga  ctttagtgc  ccagccacc  aggcctatg  ccatgagat  3540
cccctgagg  acgggaccc  gggtggctc  tttgtctcc  ccagccccc  ctccaccag  3600
agccccatc  tcagtgctg  cagcacttc  gtggggagt  tcccgtcgg  agagagcag  3660
gaccagggt  cccggacgc  cacccagcc  ctgttggag  ctggcttcc  ctcaggcag  3720
ctgggacag  ccagcccgt  tgcccagag  aactaccag  gctcttctc  tctcccgac  3780
gtgggcagt  gctacagca  ccccgacta  tcacttcag  atttcagct  ctctccgga  3840
agccaggct  gagctcagt  cagtgtggc  ggcgtccac  cggtgcctg  gagccctca  3900
gcgcgccac  gaacagtgg  caccaacac  ccccctagt  ctggcttcg  ctggcgggc  3960
atcaatccc  gcatggctg  ccccagcag  cccagtttg  gccatcacc  gatgatggg  4020
ccaccaggc  ctggcttcc  tggtagcac  gtctccagc  cccagagca  tgcagcgac  4080
accccgggg  gccccagcc  gtgtcggca  ccagcaggg  tctaccagg  ttctggcct  4140
cacaacaaa  tggccacca  cccggggag  cccagcctg  gccggcacc  tggggctca  4200
caaggcaac  tggcctccg  tcttcatag  aatgcaata  ccagccctg  aagccccag  4260
ctgggccgt  acctcggag  gtctggatc  gtggttccc  gcagcccct  cttggaccg  4320
catgtggcc  atggcggct  ttctacccc  gaggatcgg  gacccacac  gtcccggca  4380
agcagtgcc  ctggctacc  ggctccttc  acgccctcc  tccctgtct  ccctgccta  4440
taccctggc  tgagcagcc  tgccacctc  ccgtcacca  actccgcag  cttccggca  4500
gggagccca  caccagcct  gccagagaa  cgaaggatg  cagtgggag  ccgggcagg  4560
agcctcccc  actatgcca  catcaatgg  aaggtgtct  cgcctgtcg  cagcggcat  4620
tccagtccc  gcgggggca  caccgtctc  ttctcccac  ctctgcccg  cttctccaa  4680
tactccatg  cagacaaca  cccggagac  cgggctaaa  tgaagtttg  ccaggacac  4740
tctaagtat  ggtacaagc  tgagatctc  agggagcag  ccatcgcgc  cctcaagga  4800
caggagccg  gggccttca  catccgcga  agtcactcc  tccgaggcg  gtacgggct  4860
gccatgaag  tgtcttcgc  acctccaac  atcatgcag  agaataaaa  aggagacat  4920
acccatgag  tggtcaggc  ttttctgat  gagactggc  ccagaggag  caagctcaa  4980
ggctgcccc  atgagccaa  cttcggatc  ctgtctgcc  tggtctacc  gcactccat  5040
atcccattg  ccctgcctt  caagctggt  attccaaac  gagacccca  agatgaatc  5100
aaagatagc  ccggccctg  caactcaac  gcagacctg  tgaaacaag  ggcagcctg  5160
aatgtgctc  tcatcaact  tgtggacat  gagtcactc  ctgggccac  ggccatctc  5220
aaagccaca  ctgagacgt  ggctgcaga  cccacgcca  ctgccacca  cgttcactt  5280
aaagtctct  cccagggaa  cactctgac  gacaaccag  gaaagctct  tttcagacg  5340
cactaccct  tcaacactg  caccttctg  gacctggat  cacaggaaa  aaagtggat  5400
aaaacagag  gtggtgccc  tgctaagct  ttcggcttc  tggcccgga  gcagggcag  5460
accacggac  acgcctgcc  cctctttgc  gagcttgac  ccaaccagc  ggcctctgc  5520
atcgtcaac  tcgtctcca  ggtcatgct  aatgccggc  aaaagagat  aaccctgcc  5580
cttgcccag  gccagtgcc  tggggaagg  gcttgtggg  aggggaccc  tgaatcctg  5640
ccactcttg  acccagaag  aggactttg  gccaatttc  gaggagaga  gaaagtgca  5700
cgtggggag  gggaagtga  ttgcagagg  gagggggaa  agagagaga  agagagaga  5760
agagagaga  agagagaga  agatggagg  gaagaactt  gattcccct  ggtagatgg  5820
aactgcaaa  acccaaagc  tccaaaact  accaggtcc  cctaacacc  cctccctcc  5880
ctaagaaga  ggatgtcct  aaaagagaa  gaacaaacc  ccttgggaa  ccacatttt  5940
tgggggaat  gaaaagctc  gtctcccta  ctcaactgc  ttgcaaggg  aaatcaagc  6000
gggagaatc  ttttctggc  acctgtagg  taggttgtc  aaccaaaca  agccaccgt  6060
ggacatcaa  tggaagaac  tgtttgctt  aaagtatct  agacccaag  cacctcagg  6120
ctctttgct  tgcctccac  atattgtcg  gtgggtgtg  gtctgcacc  acatcctca  6180
acattgatc  agatctgcc  ttatccact  gaattataa  cagctcggc  tgtccttgt  6240
ccatgtgtt  gtagacaca  atgcatact  tccaaagat  agggttggt  gtggcagtg  6300
agcagggga  ggacaaaca  ccaagctat  ggtgacaga  gctctctcc  ggtgcctgc  6360
cctgcactc  agtgaccct  ggtgccgcc  gacccttct  ttctacaaa  accccagca  6420
gagtgggag  gtctgcaat  gcatcgccc  gtcctgcct  ggccagaag  ctggagctt  6480
ggtttgagg  ggtagagat  tgtgtatcc  taggaagag  tctgtcaga  caggcagct  6540
ttgagctcg  ggtgtcttc  ccaaggcat  tggctcagc  gcaagaaag  caagttgct  6600
ctgctgggg  cctggactc  gccttagct  ccacctctc  gccttgtta  tgggtttca  6660
gcccctgga  cagccttat  tcagacctg  ttacctgca  gatgccttt  tgggggctg  6720
ggattgagt  ttgctgctc  gcccagccc  gttctattc  gcagggtcc  tgtgttgga  6780
ttctccctg  ggaacctac  ttctgctca  tgaggctcc  gccagaaac  tggagtcct  6840
atcctcccc  ctgtaagtg  tttagggtc  ggcttttgc  ggcaccctc  gacctcagc  6900
gagctcctg  gcctgctgc  tgcacacca  atcgcctac  tacaatgcc  aagcctcac  6960
gtcaccctt  ctgccttgg  ttccctagc  gagccacgc  gcccatgca  cagagggca  7020
aaggcttgc  cttgggcca  agggcctaa  gtccactgg  cagttggga  aacacctga  7080
caccattta  ggactctaa  ccagaatgg  aaattcacc  ggactccat  cttaagcct  7140
tgcgagtcc  ctagagaga  gcattgtac  gatatataa  tattatata  tatatacat  7200
agacatact  acagaatct  taagctaat  aaatgtaag  aaaggttaa  aaaagaaaa  7260
aaaaaaa  7267



<210> 8300
<211> 1735
<212> PRT
<213> Homo sapiens
<308> NP_072174
<400> 8300

Met Ser Val Ser Arg Thr Met Glu Asp Ser Cys Glu Leu Asp Leu Val 
  1               5                  10                  15
Tyr Val Thr Glu Arg Ile Ile Ala Val Ser Phe Pro Ser Thr Ala Asn 
             20                  25                  30
Glu Glu Asn Phe Arg Ser Asn Leu Arg Glu Val Ala Gln Met Leu Lys 
         35                  40                  45
Ser Lys His Gly Gly Asn Tyr Leu Leu Phe Asn Leu Ser Glu Arg Arg 
     50                  55                  60
Pro Asp Ile Thr Lys Leu His Ala Lys Val Leu Glu Phe Gly Trp Pro 
 65                  70                  75                  80
Asp Leu His Thr Pro Ala Leu Glu Lys Ile Cys Ser Ile Cys Lys Ala 
                 85                  90                  95
Met Asp Thr Trp Leu Asn Ala Asp Pro His Asn Val Val Val Leu His 
             100                105                110
Asn Lys Gly Asn Arg Gly Arg Ile Gly Val Val Ile Ala Ala Tyr Met 
         115                120                125
His Tyr Ser Asn Ile Ser Ala Ser Ala Asp Gln Ala Leu Asp Arg Phe 
     130                135                140
Ala Met Lys Arg Phe Tyr Glu Asp Lys Ile Val Pro Ile Gly Gln Pro 
 145                150                155                160
Ser Gln Arg Arg Tyr Val His Tyr Phe Ser Gly Leu Leu Ser Gly Ser 
                 165                170                175
Ile Lys Met Asn Asn Lys Pro Leu Phe Leu His His Val Ile Met His 
             180                185                190
Gly Ile Pro Asn Phe Glu Ser Lys Gly Gly Cys Arg Pro Phe Leu Arg 
         195                200                205
Ile Tyr Gln Ala Met Gln Pro Val Tyr Thr Ser Gly Ile Tyr Asn Ile 
     210                215                220
Pro Gly Asp Ser Gln Thr Ser Val Cys Ile Thr Ile Glu Pro Gly Leu 
 225                230                235                240
Leu Leu Lys Gly Asp Ile Leu Leu Lys Cys Tyr His Lys Lys Phe Arg 
                 245                250                255
Ser Pro Ala Arg Asp Val Ile Phe Arg Val Gln Phe His Thr Cys Ala 
             260                265                270
Ile His Asp Leu Gly Val Val Phe Gly Lys Glu Asp Leu Asp Asp Ala 
         275                280                285
Phe Lys Asp Asp Arg Phe Pro Glu Tyr Gly Lys Val Glu Phe Val Phe 
     290                295                300
Ser Tyr Gly Pro Glu Lys Ile Gln Gly Met Glu His Leu Glu Asn Gly 
 305                310                315                320
Pro Ser Val Ser Val Asp Tyr Asn Thr Ser Asp Pro Leu Ile Arg Trp 
                 325                330                335
Asp Ser Tyr Asp Asn Phe Ser Gly His Arg Asp Asp Gly Met Glu Glu 
             340                345                350
Val Val Gly His Thr Gln Gly Pro Leu Asp Gly Ser Leu Tyr Ala Lys 
         355                360                365
Val Lys Lys Lys Asp Ser Leu His Gly Ser Thr Gly Ala Val Asn Ala 
     370                375                380
Thr Arg Pro Thr Leu Ser Ala Thr Pro Asn His Val Glu His Thr Leu 
 385                390                395                400
Ser Val Ser Ser Asp Ser Gly Asn Ser Thr Ala Ser Thr Lys Thr Asp 
                 405                410                415
Lys Thr Asp Glu Pro Val Pro Gly Ala Ser Ser Ala Thr Ala Ala Leu 
             420                425                430
Ser Pro Gln Glu Lys Arg Glu Leu Asp Arg Leu Leu Ser Gly Phe Gly 
         435                440                445
Leu Glu Arg Glu Lys Gln Gly Ala Met Tyr His Thr Gln His Leu Arg 
     450                455                460
Ser Arg Pro Ala Gly Gly Ser Ala Val Pro Ser Ser Gly Arg His Val 
 465                470                475                480
Val Pro Ala Gln Val His Val Asn Gly Gly Ala Leu Ala Ser Glu Arg 
                 485                490                495
Glu Thr Asp Ile Leu Asp Asp Glu Leu Pro Asn Gln Asp Gly His Ser 
             500                505                510
Ala Gly Ser Met Gly Thr Leu Ser Ser Leu Asp Gly Val Thr Asn Thr 
         515                520                525
Ser Glu Gly Gly Tyr Pro Glu Ala Leu Ser Pro Leu Thr Asn Gly Leu 
     530                535                540
Asp Lys Ser Tyr Pro Met Glu Pro Met Val Asn Gly Gly Gly Tyr Pro 
 545                550                555                560
Tyr Glu Ser Ala Ser Arg Ala Gly Pro Ala His Ala Gly His Thr Ala 
                 565                570                575
Pro Met Arg Pro Ser Tyr Ser Ala Gln Glu Gly Leu Ala Gly Tyr Gln 
             580                585                590
Arg Glu Gly Pro His Pro Ala Trp Pro Gln Pro Val Thr Thr Ser His 
         595                600                605
Tyr Ala His Asp Pro Ser Gly Met Phe Arg Ser Gln Ser Phe Ser Glu 
     610                615                620
Ala Glu Pro Gln Leu Pro Pro Ala Pro Val Arg Gly Gly Ser Ser Arg 
 625                630                635                640
Glu Ala Val Gln Arg Gly Leu Asn Ser Trp Gln Gln Gln Gln Gln Gln 
                 645                650                655
Gln Gln Gln Pro Arg Pro Pro Pro Arg Gln Gln Glu Arg Ala His Leu 
             660                665                670
Glu Ser Leu Val Ala Ser Arg Pro Ser Pro Gln Pro Leu Ala Glu Thr 
         675                680                685
Pro Ile Pro Ser Leu Pro Glu Phe Pro Arg Ala Ala Ser Gln Gln Glu 
     690                695                700
Ile Glu Gln Ser Ile Glu Thr Leu Asn Met Leu Met Leu Asp Leu Glu 
 705                710                715                720
Pro Ala Ser Ala Ala Ala Pro Leu His Lys Ser Gln Ser Val Pro Gly 
                 725                730                735
Ala Trp Pro Gly Ala Ser Pro Leu Ser Ser Gln Pro Leu Ser Gly Ser 
             740                745                750
Ser Arg Gln Ser His Pro Leu Thr Gln Ser Arg Ser Gly Tyr Ile Pro 
         755                760                765
Ser Gly His Ser Leu Gly Thr Pro Glu Pro Ala Pro Arg Ala Ser Leu 
     770                775                780
Glu Ser Val Pro Pro Gly Arg Ser Tyr Ser Pro Tyr Asp Tyr Gln Pro 
 785                790                795                800
Cys Leu Ala Gly Pro Asn Gln Asp Phe His Ser Lys Ser Pro Ala Ser 
                 805                810                815
Ser Ser Leu Pro Ala Phe Leu Pro Thr Thr His Ser Pro Pro Gly Pro 
             820                825                830
Gln Gln Pro Pro Ala Ser Leu Pro Gly Leu Thr Ala Gln Pro Leu Leu 
         835                840                845
Ser Pro Lys Glu Ala Thr Ser Asp Pro Ser Arg Thr Pro Glu Glu Glu 
     850                855                860
Pro Leu Asn Leu Glu Gly Leu Val Ala His Arg Val Ala Gly Val Gln 
 865                870                875                880
Ala Arg Glu Lys Gln Pro Ala Glu Pro Pro Ala Pro Leu Arg Arg Arg 
                 885                890                895
Ala Ala Ser Asp Gly Gln Tyr Glu Asn Gln Ser Pro Glu Ala Thr Ser 
             900                905                910
Pro Arg Ser Pro Gly Val Arg Ser Pro Val Gln Cys Val Ser Pro Glu 
         915                920                925
Leu Ala Leu Thr Ile Ala Leu Asn Pro Gly Gly Arg Pro Lys Glu Pro 
     930                935                940
His Leu His Ser Tyr Lys Glu Ala Phe Glu Glu Met Glu Gly Thr Ser 
 945                950                955                960
Pro Ser Ser Pro Pro Pro Ser Gly Val Arg Ser Pro Pro Gly Leu Ala 
                 965                970                975
Lys Thr Pro Leu Ser Ala Leu Gly Leu Lys Pro His Asn Pro Ala Asp 
             980                985                990
Ile Leu Leu His Pro Thr Gly Val Thr Arg Arg Arg Ile Gln Pro Glu 
         995                1000                1005
Glu Asp Glu Gly Lys Val Val Val Arg Leu Ser Glu Glu Pro Arg Ser 
     1010                1015                1020
Tyr Val Glu Ser Val Ala Arg Thr Ala Val Ala Gly Pro Arg Ala Gln 
 1025                1030                1035                1040
Asp Ser Glu Pro Lys Ser Phe Ser Ala Pro Ala Thr Gln Ala Tyr Gly 
                 1045                1050                1055
His Glu Ile Pro Leu Arg Asn Gly Thr Leu Gly Gly Ser Phe Val Ser 
             1060                1065                1070
Pro Ser Pro Leu Ser Thr Ser Ser Pro Ile Leu Ser Ala Asp Ser Thr 
         1075                1080                1085
Ser Val Gly Ser Phe Pro Ser Gly Glu Ser Ser Asp Gln Gly Pro Arg 
     1090                1095                1100
Thr Pro Thr Gln Pro Leu Leu Glu Ser Gly Phe Arg Ser Gly Ser Leu 
 1105                1110                1115                1120
Gly Gln Pro Ser Pro Ser Ala Gln Arg Asn Tyr Gln Ser Ser Ser Pro 
                 1125                1130                1135
Leu Pro Thr Val Gly Ser Ser Tyr Ser Ser Pro Asp Tyr Ser Leu Gln 
             1140                1145                1150
His Phe Ser Ser Ser Pro Glu Ser Gln Ala Arg Ala Gln Phe Ser Val 
         1155                1160                1165
Ala Gly Val His Thr Val Pro Gly Ser Pro Gln Ala Arg His Arg Thr 
     1170                1175                1180
Val Gly Thr Asn Thr Pro Pro Ser Pro Gly Phe Gly Trp Arg Ala Ile 
 1185                1190                1195                1200
Asn Pro Ser Met Ala Ala Pro Ser Ser Pro Ser Leu Ser His His Gln 
                 1205                1210                1215
Met Met Gly Pro Pro Gly Thr Gly Phe His Gly Ser Thr Val Ser Ser 
             1220                1225                1230
Pro Gln Ser Ser Ala Ala Thr Thr Pro Gly Ser Pro Ser Leu Cys Arg 
         1235                1240                1245
His Pro Ala Gly Val Tyr Gln Val Ser Gly Leu His Asn Lys Val Ala 
     1250                1255                1260
Thr Thr Pro Gly Ser Pro Ser Leu Gly Arg His Pro Gly Ala His Gln 
 1265                1270                1275                1280
Gly Asn Leu Ala Ser Gly Leu His Ser Asn Ala Ile Ala Ser Pro Gly 
                 1285                1290                1295
Ser Pro Ser Leu Gly Arg His Leu Gly Gly Ser Gly Ser Val Val Pro 
             1300                1305                1310
Gly Ser Pro Cys Leu Asp Arg His Val Ala Tyr Gly Gly Tyr Ser Thr 
         1315                1320                1325
Pro Glu Asp Arg Arg Pro Thr Leu Ser Arg Gln Ser Ser Ala Ser Gly 
     1330                1335                1340
Tyr Gln Ala Pro Ser Thr Pro Ser Phe Pro Val Ser Pro Ala Tyr Tyr 
 1345                1350                1355                1360
Pro Gly Leu Ser Ser Pro Ala Thr Ser Pro Ser Pro Asp Ser Ala Ala 
                 1365                1370                1375
Phe Arg Gln Gly Ser Pro Thr Pro Ala Leu Pro Glu Lys Arg Arg Met 
             1380                1385                1390
Ser Val Gly Asp Arg Ala Gly Ser Leu Pro Asn Tyr Ala Thr Ile Asn 
         1395                1400                1405
Gly Lys Val Ser Ser Pro Val Ala Ser Gly Met Ser Ser Pro Ser Gly 
     1410                1415                1420
Gly Ser Thr Val Ser Phe Ser His Thr Leu Pro Asp Phe Ser Lys Tyr 
 1425                1430                1435                1440
Ser Met Pro Asp Asn Ser Pro Glu Thr Arg Ala Lys Val Lys Phe Val 
                 1445                1450                1455
Gln Asp Thr Ser Lys Tyr Trp Tyr Lys Pro Glu Ile Ser Arg Glu Gln 
             1460                1465                1470
Ala Ile Ala Leu Leu Lys Asp Gln Glu Pro Gly Ala Phe Ile Ile Arg 
         1475                1480                1485
Asp Ser His Ser Phe Arg Gly Ala Tyr Gly Leu Ala Met Lys Val Ser 
     1490                1495                1500
Ser Pro Pro Pro Thr Ile Met Gln Gln Asn Lys Lys Gly Asp Met Thr 
 1505                1510                1515                1520
His Glu Leu Val Arg His Phe Leu Ile Glu Thr Gly Pro Arg Gly Val 
                 1525                1530                1535
Lys Leu Lys Gly Cys Pro Asn Glu Pro Asn Phe Gly Ser Leu Ser Ala 
             1540                1545                1550
Leu Val Tyr Gln His Ser Ile Ile Pro Leu Ala Leu Pro Cys Lys Leu 
         1555                1560                1565
Val Ile Pro Asn Arg Asp Pro Thr Asp Glu Ser Lys Asp Ser Ser Gly 
     1570                1575                1580
Pro Ala Asn Ser Thr Ala Asp Leu Leu Lys Gln Gly Ala Ala Cys Asn 
 1585                1590                1595                1600
Val Leu Phe Ile Asn Ser Val Asp Met Glu Ser Leu Thr Gly Pro Gln 
                 1605                1610                1615
Ala Ile Ser Lys Ala Thr Ser Glu Thr Leu Ala Ala Asp Pro Thr Pro 
             1620                1625                1630
Ala Ala Thr Ile Val His Phe Lys Val Ser Ala Gln Gly Ile Thr Leu 
         1635                1640                1645
Thr Asp Asn Gln Arg Lys Leu Phe Phe Arg Arg His Tyr Pro Leu Asn 
     1650                1655                1660
Thr Val Thr Phe Cys Asp Leu Asp Pro Gln Glu Arg Lys Trp Met Lys 
 1665                1670                1675                1680
Thr Glu Gly Gly Ala Pro Ala Lys Leu Phe Gly Phe Val Ala Arg Lys 
                 1685                1690                1695
Gln Gly Ser Thr Thr Asp Asn Ala Cys His Leu Phe Ala Glu Leu Asp 
             1700                1705                1710
Pro Asn Gln Pro Ala Ser Ala Ile Val Asn Phe Val Ser Lys Val Met 
         1715                1720                1725
Leu Asn Ala Gly Gln Lys Arg 
     1730                1735



<210> 8301
<211> 1686
<212> DNA
<213> Rattus norvegicus
<308> U26356
<400> 8301

gatccaaga  tgggtgccg  ggctgcctg  aaggccagt  cggaaagac  aaagggtcc  60
gaacaggca  cagttttgc  ggttagctt  acatcggaa  tcacttttg  ctgagcatc  120
ttttagagt  tctgtctta  ggatgcctc  gtagtggtc  ctccatgtg  taaccactc  180
acctgtggg  gtctttctt  ggagtcctc  gaatgtgcc  acatcccct  taggctcta  240
tctaaaggc  ccttctcac  ctctgtctt  gggtcaaga  gttatctgt  tccaacttt  300
atttatatt  agacaggaa  ctccaccct  cccacatac  ggttactgt  cctggtaga  360
aagtctagg  ctggcaaag  cacaattga  gtcagggct  gctcaatcg  gccatcttc  420
ctgccccat  ccctcccta  ctctggcta  gggggtcgg  gtgtgctca  cacaagaac  480
catcgacct  ccccgctac  gtccatggt  gacaaggtc  agaaaggag  tctccaaac  540
caagtccgc  acccacaaa  tgtttggcc  ggacaccag  gccacgggg  tccaggaac  600
gaagaaaca  gcctactca  ccccctcat  tatgtccat  cgtcattta  gtcccacat  660
atcctgcaa  gaccgttgc  tgctttcct  aagtcactt  ctgactaat  tctgcctga  720
cccgcttgg  aggagggac  cgggagctg  taaagaaaa  aaggtctcc  ggctctctg  780
agagtcaga  agtgtaact  accggggca  gaagatggg  cgcagctaa  cgatctgga  840
cccttgagg  tgaagtttt  aagcaccag  gaaaggaga  agccactcc  aagtccaaa  900
tgtcaagtt  cctcctccg  tgattcgag  gagggagcc  cccctgctg  actagccac  960
ccaccacag  cctgcgact  gacacagct  gatgaggag  gatcatagg  ccttatctc  1020
cccaattat  agtgctact  gggagtctg  gttagaagg  actgctgct  ctgctgctg  1080
tgctgctgc  gctgctgct  ctgctgctg  tgctgctgc  gcttgaaaa  attaaaaac  1140
aaacaaaac  aaatgtact  ggggaaatc  gcactggga  gccccttct  agaaattcg  1200
ggtccaaag  cacttggag  gccccaaac  aaagccccg  agtgggacc  ctattgaaa  1260
tctccactg  gttctaaga  agaagcccc  cttggagac  cacaggcta  gcactcctg  1320
gcagaatcc  tccctttcc  tgctcagcc  gtaccgcag  acccagcac  acagcaccc  1380
tcccacgac  tccttctct  tcacctcct  cacgcaaga  tcggggagg  ggtgcaagc  1440
ggagtggaa  gaaacagca  acatccatt  cctcctggg  gacagaggg  gcctctgtc  1500
actcctggc  ctagccctt  gggtgtcgt  tgtgaaggg  tggagccgt  gggaggagg  1560
tcggcagta  agacaggtc  ccccacact  ctccggggc  acatttgca  cgcgccctt  1620
tgtcaagaa  ctgctccga  gtcagccga  gccaaccgt  agtatccta  cctgcttag  1680
taatcg  1686



<210> 8302
<211> 2817
<212> DNA
<213> Rattus norvegicus
<308> U27186
<400> 8302

taagtgaag  gagaacctg  attattctg  ggccctgtg  gcttgtcct  ccggtgtgt  60
tcctcgggg  cggatctgc  ccggggaga  gtgggcgac  gtggaagcg  cggcggagg  120
ggcggccgg  cctttctag  tgggctctg  ctgaggtgg  gctgctcgg  attcctgga  180
ccatctcag  tgcttgtgg  gccccagaa  agtctagct  cccatgaga  cctggcaga  240
gagctgtaa  tagagatgt  cagtgtcct  aagccttaa  tgcttgctt  ccagagccc  300
gcctgaaag  gaagagaac  atgaccaag  tacaggagg  agtgacgtt  agggacgtg  360
ccgtggtct  cagtaagga  gagatgggg  tgctggacg  tgcccagag  aagctgtac  420
acgatgtga  gctggagaa  ctcaggaac  tcctggcag  gggaggcca  agtccaaat  480
agatgaaga  tgttgatgc  acaggagtg  ggtgccttt  actggggca  cttctgtac  540
gggaaataa  aggccacga  gccaacaaa  tggccagag  tccggaagc  gtagtccac  600
ctcaaggaa  gggttctca  ttcctggag  aaggccact  ctcctgcca  agggaagca  660
aggagcctc  ccggccttc  gaggatgac  gttctctcg  cagtctgac  cgtgaccat  720
ccagcacta  tgaaaatca  gaatttctg  ctgggagag  ccaggggtc  tggtgtaaa  780
cacatctta  gaaaagaca  aaccatcag  aacactgtc  gcagactct  atgaaaaac  840
agccagagc  gttgactca  cattcccct  tacaaagaa  acaggagga  agcaggcat  900
gctctagcg  ccccattca  caaagtgtt  atccaggaa  aaagcgcta  tggtgtcat  960
agtgtggca  gggtttcag  cagagctca  ctctccaga  tcaccggag  gtgcacacg  1020
gggagaagc  ctgcaggga  aacagctgt  ggaaaagct  cagtcgtag  tctggtctt  1080
gcatccacc  ccaagtaca  actggagag  gaccttacc  gtgtaaagt  tgtgggaag  1140
gtttcttgc  gtggtcaca  ctccaggcc  acgagagaa  tcacacagg  gagaagcca  1200
ataagtgtg  agaatgtgg  aaacgcttc  gctgtattt  aaaccttca  acccaccag  1260
gattccaca  caaggagaa  ccatacaag  gtgacaagt  tgggaagtg  ttcagcttg  1320
acttcaacc  tcacattca  cagcgggtc  acacaggag  gaaaccgta  aaatgtgaa  1380
agtgtggga  gtgtttcag  ttgagcttc  acctccaca  ccatcagcg  gtccacaca  1440
gagagaagc  atataaatg  gaagagtgt  ggaagtgtt  cagttcagc  tcaagtttc  1500
aaagacacc  gcagatcca  ataaaagag  agacacttc  tcgtgatgt  tgtggaaag  1560
gcagcagcc  ggactcgaa  cttcagact  accagagag  gcacataca  gagaagccc  1620
atcggtgca  cagctgtgg  aagagcttc  gctgtagca  ggatctcaa  atccaccgc  1680
gagtacata  tggagagaa  ccttacaag  gtgaggtgt  tgggaaggg  ttcaattat  1740
tgtcacacc  ccaggccca  gagaaaatt  atgcagatc  gaagccata  aagtgtgaa  1800
actgtggca  acgcttcag  tatagttca  accttcaca  ccaccagag  gttcacacg  1860
gagagaaac  ctataaatg  gaggagtgt  ggaaaagct  cagtctagc  tctagtcta  1920
aggctcatc  aagagtcca  actggcaag  agccattca  atgcaatgc  tgccaaaag  1980
gattcagtc  ggcctggaa  ctccaggcc  accagagag  gcacactgg  gagaagccc  2040
acaagtgtg  cacgtgtgg  aaagccttc  gccagaggt  cagtcttca  atccatcag  2100
gaattcaca  tggggagaa  ccattcaaa  gtgaggagt  tgggaagga  ttcagcttg  2160
attcagggc  tactgctca  cggagggtc  acacgggag  gaagcccta  gaatgcaca  2220
agtgtggga  aggctttag  cttgcctca  gtctacgaa  tcatcagcg  attcacacc  2280
gcgagaaac  cttccaatg  aatgagtgc  agaagaggt  cagtcaggt  tcacacctc  2340
agtcccacc  gagggttca  acaggggag  agccttaca  atgtgacac  tgtgggaag  2400
ccttcagtc  aaagtctgg  ctccaagtc  atcggagaa  tcacactgg  gagaagccg  2460
tcaagtgtg  ggagtgtgg  aaggaattc  tctggagct  agggcttag  gctcaccgg  2520
gggtccaca  aggagaaaa  accctgcac  gttagcagt  tgggaaggg  ttcagtcag  2580
cctcacact  ccgattaac  gtctgatcc  atgtaaaca  agcaggatc  ttatatcaa  2640
gctgttaca  aataattga  aacaaagtg  aaggtagct  gtatacaat  agaaaaagc  2700
gtatgacac  tggtgaaat  atacaatta  tcagatagc  tcctggtag  aaatgacac  2760
tatagattt  tatttaaca  ttttgcatc  cctgtatcc  ctggatata  aattaaa  2817



<210> 8303
<211> 744
<212> PRT
<213> Rattus norvegicus
<308> AAB60512
<400> 8303

Met Thr Lys Leu Gln Glu Ala Val Thr Phe Arg Asp Val Ala Val Val 
  1               5                  10                  15
Phe Ser Lys Glu Glu Met Gly Leu Leu Asp Ala Ala Gln Arg Lys Leu 
             20                  25                  30
Tyr His Asp Val Met Leu Glu Asn Leu Arg Asn Leu Leu Ala Val Gly 
         35                  40                  45
Gly Gln Ser Pro Asn Lys Met Lys Thr Val Asp Ala Thr Gly Val Arg 
     50                  55                  60
Cys Leu Leu Leu Gly Gln Leu Leu Tyr Trp Glu Ile Thr Gly His Asp 
 65                  70                  75                  80
Ala Asn Lys Leu Ala Arg Ala Pro Glu Ala Val Val His Thr Gln Gly 
                 85                  90                  95
Lys Gly Ser His Phe Leu Glu Gln Gly His Ser Ser Cys His Arg Glu 
             100                105                110
Ala Glu Glu Pro Arg Arg Pro Ser Glu Asp Asp Ser Ser Leu Asp Ser 
         115                120                125
Leu Thr Arg Asp His Ser Ser Thr Thr Glu Asn Gln Glu Phe Leu Ser 
     130                135                140
Gly Arg Ala Gln Gly Ser Trp Cys Lys Thr His Leu Arg Lys Arg Gln 
 145                150                155                160
Asn His Gln Lys His Cys Leu Gln Thr Leu Met Lys Asn Lys Pro Glu 
                 165                170                175
Leu Leu Thr Gln His Ser Pro Val Gln Arg Thr Gln Glu Asp Ser Arg 
             180                185                190
His Ser Ser Ser Val Pro Ile Gln Gln Ser Val His Pro Gly Arg Lys 
         195                200                205
Arg Tyr Trp Cys His Glu Cys Gly Lys Gly Phe Ser Gln Ser Ser Ala 
     210                215                220
Leu Gln Thr His Arg Arg Val His Thr Gly Glu Lys Pro Cys Arg Asp 
 225                230                235                240
Asn Ser Cys Arg Lys Ser Phe Ser Arg Ser Ser Gly Leu Ser Ile His 
                 245                250                255
Arg Gln Val His Thr Gly Glu Arg Pro Tyr Arg Cys Lys Val Cys Gly 
             260                265                270
Lys Gly Phe Leu Arg Trp Ser His Leu Gln Ala His Glu Arg Ile His 
         275                280                285
Thr Gly Glu Lys Pro Tyr Lys Cys Gly Glu Cys Gly Lys Arg Phe Ser 
     290                295                300
Cys Ile Ser Asn Leu His Thr His Gln Arg Phe His Ser Lys Glu Lys 
 305                310                315                320
Pro Tyr Lys Cys Asp Lys Cys Gly Lys Cys Phe Ser Leu Asn Phe Asn 
                 325                330                335
Leu His Ile His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys 
             340                345                350
Glu Glu Cys Gly Lys Cys Phe Ser Leu Ser Phe Asn Leu His Ser His 
         355                360                365
Gln Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
     370                375                380
Lys Cys Phe Ser Ser Ala Ser Ser Phe Gln Arg His Arg Gln Ile His 
 385                390                395                400
Ile Lys Glu Lys Thr Leu His Arg Asp Val Cys Gly Lys Gly Ser Ser 
                 405                410                415
Arg Asp Ser Asn Leu Gln Thr His Gln Arg Val His Ile Gln Glu Lys 
             420                425                430
Pro Tyr Arg Cys Asn Ser Cys Gly Lys Ser Phe Arg Cys Ser Met Asp 
         435                440                445
Leu Asn Ile His Arg Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys 
     450                455                460
Glu Val Cys Gly Lys Gly Phe Asn Tyr Leu Ser His Leu Gln Ala His 
 465                470                475                480
Glu Lys Ile His Ala Asp Gln Lys Pro Tyr Lys Cys Glu Tyr Cys Gly 
                 485                490                495
Arg Arg Phe Ser Tyr Ser Ser Asn Leu His Thr His Gln Arg Val His 
             500                505                510
Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ser Phe Ser 
         515                520                525
Leu Ala Ser Ser Leu Gln Ala His Gln Arg Val Gln Thr Gly Lys Lys 
     530                535                540
Pro Phe Lys Cys Asn Ala Cys Gln Lys Arg Phe Ser Gln Ala Trp Asn 
 545                550                555                560
Leu Gln Ala His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys 
                 565                570                575
Asp Thr Cys Gly Lys Ala Phe Gly Gln Arg Ser Ser Leu Gln Ile His 
             580                585                590
Gln Arg Ile His Thr Gly Glu Lys Pro Phe Lys Cys Glu Glu Cys Gly 
         595                600                605
Lys Glu Phe Ser Leu Asn Ser Gly Leu Thr Ala His Arg Arg Val His 
     610                615                620
Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys Gly Phe Ser 
 625                630                635                640
Leu Ala Ser Ser Leu Arg Thr His Gln Arg Ile His Thr Gly Glu Lys 
                 645                650                655
Pro Phe Gln Cys Asn Glu Cys Gln Lys Arg Phe Ser Gln Val Ser His 
             660                665                670
Leu Gln Ser His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys 
         675                680                685
Asp Thr Cys Gly Lys Ala Phe Ser Gln Lys Ser Gly Leu Gln Val His 
     690                695                700
Arg Arg Ile His Thr Gly Glu Lys Pro Phe Lys Cys Glu Glu Cys Gly 
 705                710                715                720
Lys Glu Phe Ile Trp Ser Ser Gly Leu Ser Ala His Arg Arg Val His 
                 725                730                735
Thr Gly Glu Lys Thr Leu His Gly 
             740



<210> 8304
<211> 1888
<212> DNA
<213> Homo sapiens
<308> NM_003445
<400> 8304

ctgctactt  acaaggtgg  ttgagccaa  tatgtgtct  gcgggtcct  gcgaaagtg  60
accagttat  aggggcgcc  aacgacctg  ggggtcaac  aaggggact  tggcacgtt  120
caggcagga  tcctccttc  ttcaaactg  atcacccag  agtctgcaa  ttccccaaa  180
taggaggaa  aatgaccac  ttcaaggag  cagtgacct  caaggatgt  gctgtggtc  240
tcactgagg  ggagctggg  ctgctggac  ctgcccaga  gaagctgta  cgagatgtg  300
tgctggaga  cttcaggaa  ctgctctca  tggggcatc  accgttcca  caagatact  360
gccacttcc  aagggaaga  aagttttgg  tgatgggga  agcaaccca  agagaaggg  420
attcaggag  caagatcca  actgagttg  agtctgttc  agaagcagg  gcacatgaa  480
agtggtcct  ccagcaaat  tgggaacaa  ttgcaaaag  cttaaccag  tctcaggac  540
ctatcataa  taactctca  ttctttgaa  atggtgatg  cccctccca  gttgaagca  600
gactaccca  aattcatac  ggacagaaa  cttcccagg  tgggaagtg  aaacagtcc  660
tcagtgatg  tcccatctt  gatcttcct  agcagtcat  ctcagaaga  aagtcttat  720
catgtgatg  gtgtggaaa  agcatctgt  acatctcag  tcttcatgt  catcagaga  780
tccacgtgg  agagaaact  tttatgtgt  atgtgtgtg  caaggaatt  agtcaaagc  840
cacatctgc  aactcatca  agagtccac  ctggagaga  accattcaa  tgtgagcaa  900
gtgggaaag  tttcagtcg  agatcagca  ttaatgttc  tcataaatt  cacacagga  960
agaaacctt  catttgtga  gcatgtggg  aggctttca  tcatgattc  cagcttaag  1020
aacataaga  aatccatac  ggggagaaa  cattcaaat  tgatatatg  ggtaagacc  1080
tctatttta  gtcaagact  aagagccat  ccatggttc  cacaggaga  aaaccattt  1140
ggtgtgata  atgtgataa  agctttcat  agagatcag  acttaatag  cattgcatg  1200
tccacacag  agagaaacc  tacagatgt  agcagtgtg  aaaaggctt  attggtagg  1260
tagattttt  taagcatca  gtggtccac  caggagaga  accatataa  tgtaaagaa  1320
gtgggaaga  cttcagatg  tcctcatgc  ttttgaacc  tcagcgagt  cacagtgga  1380
aaaaaagct  caaatgtga  gaatgtggg  agggatttt  tacaaattc  caactgtct  1440
cccatcaga  atcccacag  ggtgaaaag  catataaat  tgaggagtg  gggaagggc  1500
atgttacta  gtttaatct  gacttgcac  agagggtcc  cacgggaga  agaccttat  1560
attgtaagg  atgtgggaa  aactttagc  gggcctcaa  tattttgaa  cataagaga  1620
tccactgcc  gaaaaaacc  ttcaaatgt  aggactgtg  aaagaggct  gtacacagg  1680
cataccgta  agaccagcc  agagactat  gtggggaaa  cccatccaa  tgtgaggat  1740
gtgggagac  ctacaagag  cgcttgaat  tggatatac  tttatcatt  tttctaaat  1800
acacataac  gttcatatt  atggggtac  acgtgctat  ttaatgtgt  catacaatt  1860
atagtgatc  aatcagtgt  attggtgt  1888



<210> 8305
<211> 538
<212> PRT
<213> Homo sapiens
<308> Q12901
<400> 8305

Met Thr Thr Phe Lys Glu Ala Val Thr Phe Lys Asp Val Ala Val Val 
  1               5                  10                  15
Phe Thr Glu Glu Glu Leu Gly Leu Leu Asp Pro Ala Gln Arg Lys Leu 
             20                  25                  30
Tyr Arg Asp Val Met Leu Glu Asn Phe Arg Asn Leu Leu Ser Val Gly 
         35                  40                  45
His Gln Pro Phe His Gln Asp Thr Cys His Phe Leu Arg Glu Glu Lys 
     50                  55                  60
Phe Trp Met Met Gly Thr Ala Thr Gln Arg Glu Gly Asn Ser Gly Gly 
 65                  70                  75                  80
Lys Ile Gln Thr Glu Leu Glu Ser Val Pro Glu Ala Gly Ala His Glu 
                 85                  90                  95
Glu Trp Ser Cys Gln Gln Ile Trp Glu Gln Ile Ala Lys Asp Leu Thr 
             100                105                110
Arg Ser Gln Asp Ser Ile Ile Asn Asn Ser Gln Phe Phe Glu Asn Gly 
         115                120                125
Asp Val Pro Ser Gln Val Glu Ala Gly Leu Pro Thr Ile His Thr Gly 
     130                135                140
Gln Lys Pro Ser Gln Gly Gly Lys Cys Lys Gln Ser Phe Ser Asp Val 
 145                150                155                160
Pro Ile Phe Asp Leu Pro Gln Gln Ser Tyr Ser Glu Glu Lys Ser Tyr 
                 165                170                175
Thr Cys Asp Glu Cys Gly Lys Ser Ile Cys Tyr Ile Ser Ala Leu His 
             180                185                190
Val His Gln Arg Val His Val Gly Glu Lys Leu Phe Met Cys Asp Val 
         195                200                205
Cys Gly Lys Glu Phe Ser Gln Ser Ser His Leu Gln Thr His Gln Arg 
     210                215                220
Val His Thr Gly Glu Lys Pro Phe Lys Cys Glu Gln Cys Gly Lys Gly 
 225                230                235                240
Phe Ser Arg Arg Ser Ala Leu Asn Val His His Lys Leu His Thr Gly 
                 245                250                255
Glu Lys Pro Tyr Ile Cys Glu Ala Cys Gly Lys Ala Phe Ile His Asp 
             260                265                270
Ser Gln Leu Lys Glu His Lys Arg Ile His Thr Gly Glu Lys Pro Phe 
         275                280                285
Lys Cys Asp Ile Cys Gly Lys Thr Phe Tyr Phe Arg Ser Arg Leu Lys 
     290                295                300
Ser His Ser Met Val His Thr Gly Glu Lys Pro Phe Arg Cys Asp Thr 
 305                310                315                320
Cys Asp Lys Ser Phe His Gln Arg Ser Ala Leu Asn Arg His Cys Met 
                 325                330                335
Val His Thr Gly Glu Lys Pro Tyr Arg Cys Glu Gln Cys Gly Lys Gly 
             340                345                350
Phe Ile Gly Arg Leu Asp Phe Tyr Lys His Gln Val Val His Thr Gly 
         355                360                365
Glu Lys Pro Tyr Asn Cys Lys Glu Cys Gly Lys Ser Phe Arg Trp Ser 
     370                375                380
Ser Cys Leu Leu Asn His Gln Arg Val His Ser Gly Glu Lys Ser Phe 
 385                390                395                400
Lys Cys Glu Glu Cys Gly Lys Gly Phe Tyr Thr Asn Ser Gln Leu Ser 
                 405                410                415
Ser His Gln Arg Ser His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Glu 
             420                425                430
Cys Gly Lys Gly Tyr Val Thr Lys Phe Asn Leu Asp Leu His Gln Arg 
         435                440                445
Val His Thr Gly Glu Arg Pro Tyr Asn Cys Lys Glu Cys Gly Lys Asn 
     450                455                460
Phe Ser Arg Ala Ser Ser Ile Leu Asn His Lys Arg Leu His Cys Gln 
 465                470                475                480
Lys Lys Pro Phe Lys Cys Glu Asp Cys Gly Lys Arg Leu Val His Arg 
                 485                490                495
Thr Tyr Arg Lys Asp Gln Pro Arg Asp Tyr Ser Gly Glu Asn Pro Ser 
             500                505                510
Lys Cys Glu Asp Cys Gly Arg Arg Tyr Lys Arg Arg Leu Asn Leu Asp 
         515                520                525
Ile Leu Leu Ser Leu Phe Leu Asn Asp Thr 
     530                535



<210> 8306
<211> 704
<212> DNA
<213> Rattus norvegicus
<308> U27201
<400> 8306

accatgact  cctggcttg  gcttgtcgt  ctcctgagc  gctggagcc  tgggcactg  60
ggaacggaa  cgtgcacat  ctcgcccag  catccccag  atgccttct  caactccga  120
atcgtgatc  gggccaaag  ggtgggaaa  aagctggtg  aggaagggc  ctttggcac  180
ctggtctac  ctattaagc  aatgaagat  taccgagga  tcagtaaga  gccccatgt  240
cagtacatt  acacggaag  ctctgaaag  ctctgtggc  ttaagctag  agtcaacaa  300
taccagtac  tgctgacag  gcgcgtgta  gaaggcaag  tgtacacag  gctgtgcaa  360
tttgtggag  ggtgggacc  cctcacact  tcccagcgc  agggcctca  ttaccgcta  420
cacctgggt  gcaattgca  gatcaagtc  tgctactac  tgccttgct  tgtgacctc  480
aagaaagaa  gtctctgga  cgacatgct  tccaatttc  ggtaccctg  ctatcagtc  540
aaacactac  cctgcatcc  gcagaaggg  ggctactgc  gctggtacc  aggatgggc  600
cccccagac  agagcatca  caatgccac  gacccctga  cccagacct  tcccacctc  660
cctccttcc  atcccgctg  gcgtcccgg  cactaatct  gcca  704



<210> 8307
<211> 211
<212> PRT
<213> Rattus norvegicus
<308> P48032
<400> 8307

Met Thr Pro Trp Leu Gly Leu Val Val Leu Leu Ser Cys Trp Ser Leu 
  1               5                  10                  15
Gly His Trp Gly Thr Glu Ala Cys Thr Cys Ser Pro Ser His Pro Gln 
             20                  25                  30
Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
         35                  40                  45
Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
     50                  55                  60
Lys Gln Met Lys Met Tyr Arg Gly Phe Ser Lys Met Pro His Val Gln 
 65                  70                  75                  80
Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                 85                  90                  95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Glu Gly Lys 
             100                105                110
Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp His Leu Thr 
         115                120                125
Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
     130                135                140
Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
 145                150                155                160
Lys Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                 165                170                175
Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
             180                185                190
Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ser Asn Ala 
         195                200                205
Thr Asp Pro 
     210



<210> 8308
<211> 5487
<212> DNA
<213> Homo sapiens
<308> NM_000362
<400> 8308

tctgtcgac  tgccccaga  ctgatcctt  tctttgtcc  cttctcagc  aggatggca  60
ttcagggag  ccttccctt  ctatcgcag  gagagcagg  cctccccag  catgtccaa  120
ccagaactc  gttttgttt  cttcatagc  ctagcatca  agaaaatca  cctgtgcat  180
catggatgt  cacgggggc  agggctttg  gttgcttaa  ccagcatcc  gaaccgtgt  240
tgttgaatg  atacagaac  ccgtttgct  tgggagagc  cagaaaaca  tcttctatc  300
tatatcata  ccagctgca  acagcagat  gcttcccat  tcccagaga  taagaacca  360
agagagaga  aaagagaga  agtttgggt  tttctcctc  gtgcctgct  tctccagag  420
aactggagg  gtagcagtt  gcattcccc  gctggttcc  ccaagcaca  tcaaggtct  480
taggacatg  ccacccctc  cctgtggaa  cggtcctgc  ggggtgggt  ggtgttagt  540
ggttctggt  tgggtcaga  acacccagt  gcccaggtg  gcgtggggc  agggcgcag  600
cgagaaggg  cacgagggc  ccgctccga  gacccagcg  caagcaccg  tcccgggcg  660
gccccagcc  acccactcg  gtgcccacg  cggcattat  ccctataag  atctgaacg  720
tccgggggc  gccccgccc  gttacccct  gcccccggc  ccgccccct  tttggaggg  780
cgatgaggt  atgcggctc  gccattggt  tgagggggc  ggccccaac  gcccgaggc  840
gggtccccg  gggcccagc  ctatatcac  cggccgccc  ggcagcggc  cagagcggg  900
agcaggcag  cggcgggcg  tcagacggc  tctcctcct  ctcttgctc  tccagctcc  960
gctccttcg  cgggaggcc  cccgccgag  cctgcgcca  cgccgaggc  gcctcgctg  1020
gccccatcc  gtcccgccg  gcactcgga  ggcagcgcg  cggaggcca  ggttgcccc  1080
cacggcccg  cgggcgagc  agctcgggc  gcagcagcc  cgccggcgg  gcgcacggc  1140
actttggag  ggcgagcag  agccccggc  gcggcggca  cagcggcaa  gaccccttg  1200
ctcgggctc  tcgtgctcc  gggcagctg  agcctgggg  actggggcg  cgaggcgtg  1260
acatgctcg  ccagccacc  ccaggacgc  ttctgcaac  ccgacatcg  gatccgggc  1320
aaggtggtg  ggaagaagc  ggtaaagga  gggcccttc  gcacgctgg  ctacaccat  1380
aagcagatg  agatgtacc  aggcttcac  aagatgccc  atgtgcagt  catccacac  1440
gaagcttcc  agagtctct  tggccttaa  ctggaggtc  acaagtacc  gtacctgct  1500
acaggtcgc  tctatgatg  caagatgta  acggggctg  gcaacttcg  ggagaggtg  1560
gaccagctc  ccctctccc  gcgcaaggg  ctgaactat  ggtatcacc  gggttgtaa  1620
tgcaagatc  agtcctgct  ctacctgcc  tgctttgtg  cttccaaga  cgagtgtct  1680
tggaccgac  tgctctcca  tttcggtta  cctggctac  agtccaaac  ctacgcctg  1740
atccggcag  agggcggct  ctgcagctg  taccgagga  gggcccccc  ggataaaag  1800
atcatcaat  ccacagacc  ctgagcgcc  gaccctgcc  cacctcact  ccctccctt  1860
ccgctgagc  tcccttgga  actaactct  cccagatga  gacaatgaa  ttagtgcct  1920
ttttcttgc  aatttagca  ttggaacat  taaagaaag  tctatgctg  catatgggg  1980
ttattggga  ctatcctcc  ggccccacc  tgccccttc  ttttggttt  gacatcatt  2040
atttccacc  gggaatttc  ggtgccatg  cagaaagaa  gaggaacct  tattcctct  2100
cttcgtgat  atataatct  tattttttt  ggaaaacaa  aatgaaaaa  tactccatt  2160
gaggattgt  attcccacc  ctcttgctt  ttccccacc  caccatctc  cagaccctc  2220
tccctttgc  cttctcctc  aatacataa  ggacacaga  aaggaactt  ctgaaaggc  2280
aaccatttc  ggatcagtc  aaggcagca  gcagataga  tcaaggtgt  tgaaagatg  2340
tatacacca  gagctgcca  tgcatgtcc  aaccagact  tgtctgtct  tgtctgcat  2400
taagagtga  ggagggaag  aaggaacta  aagagagtc  gagatgatg  agcacacac  2460
caattcccc  gcccagtga  gcttgtgtt  accagatgt  cctgagtct  gagcaagca  2520
ccaggccag  ataacagag  tttcttagt  ggtgaagac  taaacatct  cctgaggtc  2580
ggaggcaat  tgcctgcct  gtacaaaag  tcaggtgaa  gactgagat  aatgtcttt  2640
ctctccctg  ctcccacca  acttcctcc  ggaaaacgc  ttggtagat  tggccagga  2700
ctttctttt  tgtaaattg  ataaataca  acaccatac  ctatccaca  atatagcca  2760
gtagatttg  gtagaggat  ctatttcca  aatagtgtt  agctcacct  gggggatat  2820
tttgtatac  catttgcat  tacccacat  gggacataa  ctaattttt  tacaggaca  2880
agaattctg  tcaatgctg  taaatatgc  aatagttta  tctcttcta  tttgttgtc  2940
ttgcttgtt  gaagaaaat  atgacattc  aagttgaca  ttttttttc  ttttaatta  3000
aatttgaaa  tctgaacac  gtcagcacc  tctcttccc  atcatgggt  atctgaccc  3060
tgtccgtct  cttgtccct  cttcatgtt  gggggcctt  ctttaactg  cttcctggc  3120
tagctcaga  ggcagatga  agtgtagtc  agggcctgg  cacaggagg  agagctgca  3180
agtgtcctg  ctgccttgg  tggagggac  cctctcctg  gtgtggaga  agcttggtt  3240
cctttccct  gctccctgg  gggtgaatg  cacctcctg  gatcctcac  tcttggaat  3300
aaaattgtt  gtcactggg  aaagcctga  tttgcaacc  gttgtaggg  ttctgttgt  3360
ttttttttt  tttttttga  ataaaacta  aatataaat  ctcctatta  ataaaatta  3420
tttaagttt  agtgtcaaa  gtgagatgc  gagagtagg  gataatgta  attttacag  3480
gtgggggtt  gcaggatgg  gacattgaa  atgattgct  tctgtctct  ttttcagct  3540
atgggtatt  atcttctat  agtatttgt  tcttcagtt  attccactt  aggaaacag  3600
gctgccaat  gaaacagaa  aagaaaaaa  aaaaaagca  cagacaaca  actgtagag  3660
cttgcacac  cacaagtgc  caggcaagg  gcttggcag  accgcagag  gggaagaga  3720
taccggcat  gggtttcct  gggatcaat  tcattaccg  gtacctttc  cattgtggt  3780
atgccattt  gcaggggga  aatgggagg  ttggccttc  ttgtgaggc  gtgtgagca  3840
aagctgatg  cagcatgtc  ctggttttg  agggatgag  ccagacttg  tgttttggg  3900
ttgtcctta  tttaacctc  aggtctcgc  tggtggggc  cctgaccaa  ctacacaag  3960
tccctccca  aagtggaca  cagtgtctt  tctgtgagg  atctggcca  tcgcactcc  4020
tggtgtggt  agcctctct  acacaagga  gaacttggg  gaaggctga  tgtgaggca  4080
ctgaagttt  cctgcggag  cgataaatt  gcagaacca  atccccatc  gttaggcct  4140
ggtgaggag  ccctgggca  agaagggtc  ttcgcaaag  gatgtcaga  ggcggtttt  4200
agctttcta  aagctatag  tttgtttat  tcacccgtt  acttactgt  taatttaaa  4260
tcatttatg  agctgagac  cttctgtat  tcaatcata  catgaacat  ttattttgc  4320
aaatcttgt  tcatgtgta  gctgtaata  gtgtacatt  tgtttaaga  aaaaatgaa  4380
cccacatgc  gccattttc  tgaatcaaa  tctgcagtg  aatggagag  aaaatactt  4440
taggcaagc  gctagactg  tgaattggg  gaaatagaa  gaactagta  ctgagactc  4500
tccagcctc  tccctattg  aatcccaat  gctcctgga  taggaaaaa  gtttaaact  4560
cattcatgt  cttgttctg  gtcactcgg  cctgggtag  ctaccattt  cttcacccc  4620
agtcctgct  cccatccag  tgggaagcc  tgattttcc  aagaatcca  ggccatggg  4680
gatacaatt  caagttctc  cttcctcct  tgggcatct  ttctgcctc  caatcaagg  4740
agctccatg  tcaggctct  agctctcgg  ccagtgctc  gctctgtcc  gggtaggta  4800
tactgggag  ctcctgtct  ttaccctcc  ctcgttcca  acctgcctc  tggtggcaa  4860
atggttctt  aacaattaa  gaaacaaat  actttttgg  atagccctg  ctagggcaa  4920
ctgtggccc  caggagaca  tacccttcc  tgccccaga  ctctgtctt  catgtgaca  4980
ttgacaatc  ggactaccc  aagatggca  ccaagtgtt  ggcttctgg  tacctaagg  5040
taacatgtc  ctagagtat  tttatgaga  acaaacatt  taaaaatct  atggcaaaa  5100
caaaacaaa  tggaaagta  gggaggtgg  tgtgacaac  acttccaaa  tggctcttt  5160
gaggcgaga  gaaggggag  acttggaga  tagtttttg  tttgggggt  gaggcttct  5220
agattctcc  agcatccgc  tttcccttt  gccagtctg  tgtcctgaa  cccagaagt  5280
atggagaga  accaacaag  gatctcgaa  cctgtctag  aggaatgta  ttgttgcta  5340
atttcgtag  actgtttac  gttttcctc  atgttattt  tgaatttta  attccgtga  5400
tgtatattg  cttgtaatg  tgcataatg  tcacttttt  tagtgtgtc  tttattcta  5460
acagtaaag  ggttttatt  ctatcac  5487



<210> 8309
<211> 211
<212> PRT
<213> Homo sapiens
<308> P35625
<400> 8309

Met Thr Pro Trp Leu Gly Leu Ile Val Leu Leu Gly Ser Trp Ser Leu 
  1               5                  10                  15
Gly Asp Trp Gly Ala Glu Ala Cys Thr Cys Ser Pro Ser His Pro Gln 
             20                  25                  30
Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
         35                  40                  45
Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
     50                  55                  60
Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
 65                  70                  75                  80
Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                 85                  90                  95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
             100                105                110
Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
         115                120                125
Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
     130                135                140
Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
 145                150                155                160
Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                 165                170                175
Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
             180                185                190
Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
         195                200                205
Thr Asp Pro 
     210



<210> 8310
<211> 5350
<212> DNA
<213> Rattus norvegicus
<308> U27319
<400> 8310

gaattccaa  acagccagg  gtacacaga  ggaccgtgt  ttgaaaaaa  aaccaacca  60
ccaatcaac  taacccatg  atgaagcct  aagagatga  tcagtggta  agagttttt  120
actgctcta  cagaggacc  aagttcaat  cccagcacc  actggtgtc  cacaaacat  180
tttaactcc  gttccaggg  acctgatgt  ctcttctga  ctcctcaag  atcaggaac  240
tgtatggta  gtacacaca  acacacaca  acacacaca  acacacaca  acacacact  300
tacatacat  tatacatgt  agcaaaatc  tcatataaa  aaacctaaa  aaattaaaa  360
taaatccag  catagtagc  atcaccttg  gccttgcgc  tcccaggca  gcgctctac  420
actgagcta  atccccaac  ccatagtag  gataacctt  aagcccagc  cttgggagg  480
agaggtagg  agatctctg  gagttcaag  ccagcctgg  ctatatagt  ccaggactg  540
caaagctat  cagtaagac  ctgtttcaa  aactaataa  aaaccaaca  gaaacattc  600
tgaggtagc  tagggctta  ccaagagaa  atacaacac  gccatagtg  tgcctccag  660
gaatggcct  atggaagtg  taaggcctg  tccggcaga  cgtctcccc  atcagggag  720
cagtcttga  tcagttgct  atctggccc  gtctgcctg  ggtggtggg  tgggatgga  780
agagtgctg  ctaagcctc  gagtcccgg  tcgaaattc  acggcaacc  gccgctggg  840
aagatggcc  accagctgc  caccctaca  cttgtttgt  gagaagagc  ctggtctcc  900
ttcgcatgg  ctctgagca  tgtctgagt  tgccctgtg  aggtgctgg  gcctgggag  960
ccagggtga  tggctgagg  caggggagg  cagctcggg  aggaggtca  atgtgcctt  1020
ctgtggtga  gtcggaacc  ggacaggtg  aggagaatc  ggacggaag  gtggtatcg  1080
ggggagcca  acagagtgg  tgtgtgggg  taaggacag  gggacacac  agtgctgtc  1140
gtcaggggc  gggtaagag  ttccgcgct  agagtccgg  aacagggcc  gtgtgttta  1200
attggcttc  accaggatg  agggcccag  agggacttt  agcaggggc  taacgtaat  1260
aaggttgct  ttcagtgag  ctgtcgcgg  ctgcagcac  gaatggctt  gatggcggg  1320
agcaaccaa  cagaaagcc  gctcaaatc  ttcttgtca  atttctagc  agacaagag  1380
aaaactggg  tggaggtgg  gttgggagt  gcagtgagt  tgacttaga  agatatgca  1440
taggaaaca  cactaagcc  cggtgcctg  gtgtatgtg  gtgtgtctg  gtcctgagt  1500
accttggta  aggggttga  ggaagggac  gcagaggta  ctacctgcc  acaagctgg  1560
ccagctttt  cccagctct  gtttgttgg  taagggttg  atccccata  aatcccaca  1620
attatagtg  tggctgaag  ttgggggag  ggtccatga  cccgacact  gggttggag  1680
atggggtgg  ccattcaac  tacagacct  tgagaaaac  aaacaaccc  ccatcccca  1740
agacttgcc  gccttgaga  ctggccgaa  tacatttgc  gattcaaat  cagctcaga  1800
gaaccattt  tgtcttgac  ctgtcaggc  atattggta  cgtgtgtgt  tgtgtgtgt  1860
ttagtttga  atttacgtg  gactcaatg  taatctttt  aagggaagg  caactataa  1920
aggccctcc  tgggctgga  atggtgaca  tcaggtgac  ggtccccca  actttaacc  1980
gtaggttcc  gagtccgtt  tatgagagt  cctcccatc  aatctatta  ataccagtg  2040
ttatgctct  tcagaaaaa  tacagggtg  aggcatcag  tccatctta  gggtaaaga  2100
agaaagcct  agaggtgac  caggacaca  ctgcaccag  cattaggca  ggtggtggc  2160
ggaagggcc  tgggatact  gaagggcac  ctggggtat  tttgccccg  tggatgctg  2220
gcctagcca  gggctccca  tccccaggc  tggggtaga  gttggactc  atagtcacc  2280
aagggccta  gttgcagtc  tggtctcag  cacacggcc  gcaggagag  cttaaaaga  2340
gagaaactg  acacaatgg  taggtcacc  gcgttaaag  taagcaaac  cagcgctac  2400
cctgggcag  aactgcaaa  cgtttcttc  ggtccctca  ctgtagaat  agagcggta  2460
tcgcctctg  atgtctgag  tcttacatg  cgtaatgta  aaacacgat  tcccctcaa  2520
caccgcccg  aacagtacc  ccaacttcc  agacccgga  gccccaaga  ccagagtag  2580
gtgggaaaa  cgggacagg  ccccaaatt  cactcgggg  ccttgagct  ttacatggt  2640
tcacggggg  aggtagttt  ggtttagca  tgtgaactc  gacaatttg  gatgtagag  2700
tggtgggcc  tcgtgggac  ccaagcatc  tccttagag  ttggatcct  tagggcagg  2760
aggcacagg  acccagtgc  agatcagtg  agccgccca  tttcggctt  cgctctttt  2820
ccacgccca  ttgcgtgct  ctccaacag  gtggatggg  ggggtgggg  acgagccct  2880
atctccgag  aaggggtgt  gccccgttc  tgttctcca  tttgtggcg  cctggatct  2940
tcctctggt  ccctccaga  cgtgtccca  acccacccg  tcaggcatg  cactgtgcc  3000
ccacgcgtg  ccgtgcgct  cttacgtgg  ggacgtgca  ggtgctgcc  cctttccgg  3060
gcgggaggg  gcggccgtc  ttctcctgc  ctggctggg  agccccagc  attgcgctg  3120
agaggagac  tgcagccaa  ggggactga  gaagtgggc  ggctggcgg  tgtcaccct  3180
ccggggacc  gagctccga  gtctggaga  cgcaggcag  cgcccgccc  gcccgggga  3240
tgaggggga  gagcgaagg  aggaggagg  ggagtctcc  atctgccgc  ggaggacca  3300
tgctcacca  ggctactga  gagccactg  ccccacacc  gcttttccg  atcccccac  3360
gtcagcatg  tcgccgcgc  actactggc  tattacttc  ccgagctga  ggatgacca  3420
gtcaaaaag  tgagccccg  cggcgccgc  ctggccaca  ccttgcatt  ccgcatccg  3480
tcgccaccg  ctgcatcct  ccccggcct  tcccagaca  catctggtt  gactacagg  3540
tgcaggcga  aggcctcgt  ctgggattc  ccccggcat  gtcggcatg  gggcgtgct  3600
gtgctttga  gagctgggc  gccgtctga  gaccccccc  ttcgctccc  ccacggctg  3660
attgcatac  gcagtgtcc  tgaaaagga  catggatgt  agatgggta  ccgcacgct  3720
tgccgggct  cgacctggc  gggtgggga  aagcgggcc  gtctataag  cctgtttgg  3780
aaggtccac  cgccgtggg  ggggaaggt  tgatcaccg  gatatgttg  ggaggtgag  3840
gagcagctg  tgggggtgc  ggctgaaag  caggcatcc  atatttggg  tttccattt  3900
gagaatgcg  tgcccttcc  aaactgtca  tgggctccc  cagctgttg  aactgctcc  3960
tactctgag  acggggtga  ccgcctggc  ttccggtgc  gggagaaca  aggccaccg  4020
aaactttgc  cataggcct  aggtctgga  ccgcatgtc  gaatggaat  ttttattct  4080
ctaaagctg  aatttccag  cagtcccag  cccggggct  aaaaaagac  ctttagtca  4140
ttgaacagc  cagagcggt  gacatgcgt  ccttgtgac  tgtgtgttc  tacacatgg  4200
ggctgggtc  taggggtga  gtttatcta  tgtaaagtg  cgtctgctg  tgggtctta  4260
agatgtacc  cacttttct  acactgtta  acaggatgt  tttcctgaa  tagcctaag  4320
tggtagggg  cacatccag  acattttta  tagtgcaac  ggtatgcct  gcctactct  4380
gggtaggta  tagtatcat  aacctgact  acactggga  aaggagtac  atctacagg  4440
gagagagag  cagaggtga  tagggtctg  cctttcccg  ctgagacct  atcctggta  4500
gaagcagtc  tactgggga  cgtgacctc  tgaaggtca  acagctggt  agaggtagg  4560
gccaaggcg  gctatgacc  cctcccact  gagagcttg  ccaggactc  cccacccct  4620
gtatcagct  aaggggagg  gctgagaga  aagctcgtg  agatgctgt  cccatcctg  4680
atctcagcc  ggatgggga  caggagtag  gtgctgagg  gatgggata  gacctcagg  4740
agctatgca  cagcccgtg  tattccgtg  tggtggaca  tgctgatgc  tagccctcg  4800
aagggggag  cagaagtcc  agcagggca  agggcactt  gaatacgcc  cctgaatca  4860
agagttcac  gctctccca  tctagatac  ctctgtggc  caggcatgc  atcctgggc  4920
gaggcccag  gaatgacct  tgtaaacta  gcctccggc  tcacccaca  ccacctgtg  4980
ggccgccag  tgcccggct  ctcctttac  tggtgctgg  tggccttga  tgagctgga  5040
taaggtttg  cagactaca  tgctccact  caagtagcc  gatccatct  catcccatt  5100
gatctccca  acccagtga  tgcttgagc  ctgattcaa  ccgtgccta  ctgaagccc  5160
caccctgat  tcccctccc  cacctctat  ctagagcct  gctggagga  gggtcttga  5220
gttgaaact  tcaccttgt  tgtgtagga  atccttaga  acaagagct  ccagcaagc  5280
ggtggtggc  caagccttt  atcccagct  ttgggaggc  gaggcgagg  aggtggatc  5340
ctgtgaattc  5350



<210> 8311
<211> 918
<212> PRT
<213> Rattus norvegicus
<308> AAC52945
<400> 8311

Met Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys Asp 
  1               5                  10                  15
Asp Gln Val Lys Lys Ile Asp Lys Tyr Leu Tyr Ala Met Arg Leu Ser 
             20                  25                  30
Asp Glu Ile Leu Ile Asp Ile Leu Thr Arg Phe Lys Lys Glu Met Lys 
         35                  40                  45
Asn Gly Leu Ser Arg Asp Tyr Asn Pro Thr Ala Ser Val Lys Met Leu 
     50                  55                  60
Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu Lys Gly Asp Phe 
 65                  70                  75                  80
Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile Leu Arg Val Gln 
                 85                  90                  95
Val Asn His Glu Lys Asn Gln Asn Val Ser Met Glu Ser Glu Ile Tyr 
             100                105                110
Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Thr Gln Leu Phe Asp 
         115                120                125
His Val Ala Asp Cys Leu Gly Asp Phe Met Glu Lys Lys Lys Ile Lys 
     130                135                140
Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe Pro Cys Arg Gln 
 145                150                155                160
Ser Lys Ile Asp Glu Ala Val Leu Ile Thr Trp Thr Lys Arg Phe Lys 
                 165                170                175
Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu Leu Asn Lys Ala 
             180                185                190
Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val Ala Val Val Asn 
         195                200                205
Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp Gln Gln Cys 
     210                215                220
Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu 
 225                230                235                240
Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys 
                 245                250                255
Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Glu Asp 
             260                265                270
Ile Arg Thr Glu Phe Asp Arg Glu Leu Asp Arg Gly Ser Leu Asn Pro 
         275                280                285
Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met Tyr Met Gly Glu 
     290                295                300
Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Gly Leu Leu Phe 
 305                310                315                320
Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly Lys Phe Asn Thr 
                 325                330                335
Ser Asp Val Ser Ala Ile Glu Lys Asp Lys Glu Gly Ile Gln Asn Ala 
             340                345                350
Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser Asp Val Asp Cys 
         355                360                365
Val Ser Val Gln His Ile Cys Thr Ile Val Ser Phe Arg Ser Ala Asn 
     370                375                380
Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg Leu Arg Asp Asn 
 385                390                395                400
Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val Asp Gly Ser Leu 
                 405                410                415
Tyr Lys Met His Pro Gln Tyr Ser Arg Arg Phe His Lys Thr Leu Arg 
             420                425                430
Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu Ser Glu Ser Gly 
         435                440                445
Thr Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
     450                455                460
Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His Phe Arg Leu Ser 
 465                470                475                480
Lys Gln Thr Leu Met Glu Val Lys Lys Arg Leu Arg Thr Glu Met Glu 
                 485                490                495
Met Gly Leu Arg Lys Glu Thr Asn Ser Lys Ala Thr Val Lys Met Leu 
             500                505                510
Pro Ser Phe Val Arg Ser Ile Pro Asp Gly Thr Glu His Gly Asp Phe 
         515                520                525
Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys 
     530                535                540
Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His Asn Lys Ile Tyr 
 545                550                555                560
Ser Ile Pro Leu Glu Ile Met Gln Gly Thr Gly Asp Glu Leu Phe Asp 
                 565                570                575
His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr Met Gly Ile Lys 
             580                585                590
Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys His Gln 
         595                600                605
Thr Asn Leu Asp Cys Gly Ile Leu Ile Ser Trp Thr Lys Gly Phe Lys 
     610                615                620
Ala Thr Asp Cys Glu Gly His Asp Val Ala Ser Leu Leu Arg Asp Ala 
 625                630                635                640
Val Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                 645                650                655
Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu Glu Pro Thr Cys 
             660                665                670
Glu Ile Gly Leu Ile Val Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu 
         675                680                685
Glu Met Lys Asn Val Glu Met Val Glu Gly Asn Gln Gly Gln Met Cys 
     690                695                700
Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
 705                710                715                720
Ile Arg Thr Asp Phe Asp Lys Val Val Asp Glu Tyr Ser Leu Asn Ser 
                 725                730                735
Gly Lys Gln Arg Phe Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
             740                745                750
Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys Gly Phe Leu Phe 
         755                760                765
Arg Gly Gln Ile Ser Glu Pro Leu Lys Thr Arg Gly Ile Phe Glu Thr 
     770                775                780
Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val 
 785                790                795                800
Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr Cys Asp Asp Ser 
                 805                810                815
Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Lys Arg Ala Ala Gln 
             820                825                830
Leu Cys Gly Ala Gly Met Ala Ala Val Val Glu Lys Ile Arg Glu Asn 
         835                840                845
Arg Gly Leu Asp His Leu Asn Val Thr Val Gly Val Asp Gly Thr Leu 
     850                855                860
Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His Gln Thr Val Lys 
 865                870                875                880
Glu Leu Ser Pro Lys Cys Thr Val Ser Phe Leu Leu Ser Glu Asp Gly 
                 885                890                895
Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly Val Arg Leu Arg 
             900                905                910
Gly Asp Pro Ser Ile Ala 
         915



<210> 8312
<211> 3580
<212> DNA
<213> Homo sapiens
<308> NM_000188
<400> 8312

ccgccggag  accacggct  gccagggct  cggaggacc  accgtcccc  cgcctgccg  60
cccgcgacc  cgaccgcca  catgatcgc  gcgcagctc  tggcctatt  cttcacgga  120
ctgaaggat  accaggtca  aaagattga  aagtatctg  atgccatgc  gctctccga  180
gaaactctc  tagatatca  gactcgctt  aggaaggag  tgaagaatg  cctctcccg  240
gattttaat  caacagcca  agtcaagat  ttgccaaca  tcgtaaggt  cattcctga  300
ggctctgaa  agggagatt  cattgccct  gatcttggt  ggtcttcct  tcgaattct  360
cgggtgcaa  tgaatcatg  gaaaaacca  aatgttcac  tggagtccg  ggtttatga  420
accccagag  acatcgtgc  cggcagtgg  agccagctt  ttgatcatg  tgctgagtg  480
ctgggagat  tcatggaga  aaggaagat  aaggacaag  agttacctg  gggattcac  540
ttttctttt  cttgccaac  atccaaaat  gatgaggcc  tcctgatca  ctggacaaa  600
cgatttaaa  cgagcggag  ggaaggagc  gatgtggtc  aactgctta  caaagccat  660
aaaaagcga  gggactatg  tgccaacat  gtagctgtg  tgaatgaca  agtgggcac  720
atgatgacc  gtggctatg  cgaccagca  tgtgaagtc  gcctgatca  cggcactgg  780
accaatgct  gctacatgg  ggaactgag  cacattgat  tggtggaag  agacgaggg  840
aggatgtgt  tcaatacag  atggggagc  tttggagac  atggatcat  agaagacat  900
cggacagag  ttgacaggg  gatagaccg  ggatccctc  accctggaa  acagctgtt  960
gagaagatg  tcagtggca  gtacttggg  gagctggtt  gactgatcc  agtcaagat  1020
gccaaggag  gcctcttat  tgaagggcg  atcaccccg  agctgctca  ccgagggaa  1080
tttaacacc  gtgatgtgt  agccatcga  aagaataag  aaggcctcc  caatgccaa  1140
gaaatcctg  cccgcctgg  agtggagcc  tccgatgat  actgtgtct  agtccagca  1200
gtttgcacc  ttgtctcat  tcgctcagc  aacttggtg  ctgccacac  gggcgccat  1260
ttgaaccgc  tgcgtgata  caagggcac  cccaggctg  ggaccacgg  tggtgtcga  1320
ggatctctt  acaagacgc  cccacagta  tcccggcgt  tccacaaga  tctaaggcg  1380
ttggtgcca  actccgatg  gcgcttcct  ctctcggag  gtggcagcg  caagggggc  1440
gccatggtg  cggcggtgg  ctaccgctt  gccgagcag  accggcaga  agaggagac  1500
ctggctcat  tccacctca  caaagacat  ctgctggag  tgaagaaga  gatgcgggc  1560
gagatggag  tggggctga  gaagcagac  cacaacaat  ccgtggtta  gatgctgcc  1620
tccttcgtc  ggagaactc  cgacgggac  gagaatggt  acttcttgg  cctggatct  1680
ggaggaacc  atttccgtg  gctgctggt  aaaatccgt  gtgggaaaa  gagaacggt  1740
gaaatgcac  acaagatct  cgccattcc  attgaaatc  tgcagggca  tggggaaga  1800
ctgtttgat  acattgtct  ctgcatctc  gacttcttg  actacatgg  gatcaaagg  1860
cccaggatg  ctctgggct  cacgttctc  tttccctgc  agcagacga  tctggacgc  1920
ggaatcttg  tcacgtgga  aaagggttt  aaggcaaca  actgcgtgg  ccacgatgt  1980
gtcacctta  taagggatg  gataaaaag  agagaggaa  ttgacctgg  cgtggtggc  2040
gtggtcaac  acacagtgg  caccatgat  acctgtgct  atgaggagc  cacctgtga  2100
gttggactc  ttgttggga  cggcagcaa  gcctgctac  tggaggaga  gaagaacgt  2160
gagatggtg  agggggacc  ggggcagat  tgcatcaac  tggagtggg  ggcctttgg  2220
gacaacggg  gtctggatg  tatcaggac  cactacgac  gactggtga  cgaatattc  2280
ctaaatgct  ggaaacaaa  gtatgagaa  atgatcagt  gtatgtacc  gggtgaaat  2340
gtccgcaac  tcttaatcg  cttcaccaa  aagggattc  tcttccgag  gcagatctc  2400
gagacgatg  agacccggg  catctttga  accaagttt  tctctcaga  cgagagtga  2460
cgattagca  tgctccagg  ccgggctat  ctccagcag  taggtctga  tagcacctg  2520
gatgacagt  tcctcgtca  gacagtgtg  ggggtggtg  ccaggaggg  cgcacagct  2580
tgtggcgca  gcatggctg  ggttgtgga  aagatccgc  agaacagag  actggaccg  2640
ctgaatgtg  ctgtgggag  ggacgggac  ctctacaag  ttcatccac  cttctccag  2700
atcatgcac  agacggtga  ggaactgtc  ccaaaatgt  acgtgtcct  cctcctgtc  2760
gaggatggc  gcggcaagg  ggccgccct  atcacggcc  tgggcgtgc  gttacgcac  2820
gaggcaagc  gctaagagt  cgggatccc  agcctactg  ctctccagc  cttctctct  2880
caagcggcg  ccccctacc  tcccagcga  ttgcgctgg  agacgctgg  gccagggcc  2940
gccggcgcg  ggaggaaag  aaaatccaa  taatggtat  tattgtagg  tacagaata  3000
agcgtgtgc  gttgataat  tctctcacc  ggatccctc  tcacttgcc  tgccacttt  3060
catggtttg  ttttgacct  gtcccccac  tgtgaagtg  agtggcatc  atttctaat  3120
tatgcattc  tccaacaga  ttatttatt  gctggagat  gaaaatcac  ccacctgac  3180
ggccttctg  gcctccaaa  cccatcctt  gggttcccc  tccctgtgt  aaatgtatt  3240
tcaccagca  acactgccg  gcctccctc  cgggggcac  gcctgaagg  gagtgtggg  3300
atagcatta  ctgcttcct  ccctcctgg  acccactgt  gcctggcat  gcatcgtgg  3360
gtgtcaatg  cacaaaatc  tgtgtccgt  gaaccagtc  tagccgcgt  tgacagtct  3420
gcattctgt  tgtctcgtg  ggggaggtg  acagtcctg  ggaaatgtg  cttgtcttc  3480
atttggata  aaggaacca  ccaacaaac  atgccatca  tggaatttc  caccgcttt  3540
tgagccgtg  cgtatgacc  agtaaactt  gtaccaattc  3580



<210> 8313
<211> 917
<212> PRT
<213> Homo sapiens
<308> P19367
<400> 8313

Met Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys Asp 
  1               5                  10                  15
Asp Gln Val Lys Lys Ile Asp Lys Tyr Leu Tyr Ala Met Arg Leu Ser 
             20                  25                  30
Asp Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg Lys Glu Met Lys 
         35                  40                  45
Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr Val Lys Met Leu 
     50                  55                  60
Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu Lys Gly Asp Phe 
 65                  70                  75                  80
Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile Leu Arg Val Gln 
                 85                  90                  95
Val Asn His Glu Lys Asn Gln Asn Val His Met Glu Ser Glu Val Tyr 
             100                105                110
Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser Gln Leu Phe Asp 
         115                120                125
His Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys Arg Lys Ile Lys 
     130                135                140
Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
 145                150                155                160
Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr Lys Arg Phe Lys 
                 165                170                175
Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu Leu Asn Lys Ala 
             180                185                190
Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val Ala Val Val Asn 
         195                200                205
Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp Gln His Cys 
     210                215                220
Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu 
 225                230                235                240
Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys 
                 245                250                255
Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Glu Asp 
             260                265                270
Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly Ser Leu Asn Pro 
         275                280                285
Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met Tyr Leu Gly Glu 
     290                295                300
Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Gly Leu Leu Phe 
 305                310                315                320
Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly Lys Phe Asn Thr 
                 325                330                335
Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly Leu His Asn Ala 
             340                345                350
Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser Asp Asp Asp Cys 
         355                360                365
Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn 
     370                375                380
Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg Leu Arg Asp Asn 
 385                390                395                400
Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val Asp Gly Ser Leu 
                 405                410                415
Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His Lys Thr Leu Arg 
             420                425                430
Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu Ser Glu Ser Gly 
         435                440                445
Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
     450                455                460
Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His Phe His Leu Thr 
 465                470                475                480
Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg Ala Glu Met Glu 
                 485                490                495
Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val Val Lys Met Leu 
             500                505                510
Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu Asn Gly Asp Phe 
         515                520                525
Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys 
     530                535                540
Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His Asn Lys Ile Tyr 
 545                550                555                560
Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp 
                 565                570                575
His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr Met Gly Ile Lys 
             580                585                590
Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
         595                600                605
Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr Lys Gly Phe Lys 
     610                615                620
Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu Leu Arg Asp Ala 
 625                630                635                640
Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                 645                650                655
Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu Glu Pro Thr Cys 
             660                665                670
Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
         675                680                685
Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln Gly Gln Met Cys 
     690                695                700
Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
 705                710                715                720
Ile Arg Thr His Tyr Asp Arg Leu Val Asn Glu Tyr Ser Leu Asn Ala 
                 725                730                735
Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
             740                745                750
Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys Gly Phe Leu Phe 
         755                760                765
Arg Gly Gln Ile Ser Glu Thr Met Lys Thr Arg Gly Ile Phe Glu Thr 
     770                775                780
Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val 
 785                790                795                800
Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr Cys Asp Asp Ser 
                 805                810                815
Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg Arg Ala Ala Gln 
             820                825                830
Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys Ile Arg Glu Asn 
         835                840                845
Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val Asp Gly Thr Leu 
     850                855                860
Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His Gln Thr Val Lys 
 865                870                875                880
Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu Ser Glu Asp Gly 
                 885                890                895
Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly Val Arg Leu Arg 
             900                905                910
Thr Glu Ala Ser Ser 
         915



<210> 8314
<211> 1489
<212> DNA
<213> Rattus norvegicus
<308> U27767
<400> 8314

atactataa  tatatttta  tgtctatac  cctcgaggt  agctacgtc  acggttaaa  60
aagatgtgc  aaggactcg  tggtctgcc  gcttcctgc  tgaggagcg  aaaggatat  120
aaacatcgg  tgggatttc  gctgcagaa  tcagattcc  gtgaacata  ttcttcaca  180
agcaagaag  acaaagtag  aacttgcca  agggtgagc  aagaagaag  caagaaatg  240
gctgaatcg  tggaaaacc  gattaacca  gaatgtgga  tggcagctt  caaagcttt  300
ctgaagtca  aatacagtg  ggagaacat  gacttctgg  tcagctgtg  ggagtacaa  360
aaaatcaaa  caccttcta  actaagtcc  aaggccaag  agatctaca  tgagttcat  420
tctgtgcag  caacaaaag  ggtgaacct  gattcttgc  ccagagagg  gacaagccg  480
aacatgtta  agcccacga  aacctgttt  gatgaagcc  agaagaaga  tttcaacct  540
atggaaaag  attcatacc  tcgtttcct  aagtctcga  tctatcttg  cctgaccaa  600
ccttccagc  gcggggcag  gaagcagaa  ggagccaag  gttctgcag  ctgcacttc  660
ctagtccct  agtgtgcct  attctcaca  agaggcaga  aaccgaaat  ccaagactc  720
atgctctgg  aaacctgag  ccaaatatt  atctgtatt  agcatcaat  ctttctcca  780
attgtagcc  agtatccat  ctgcctgcc  tgtgtgagt  acttccatg  aaaactaga  840
ttagctgtg  tgtgggggt  ttcattggg  taagaccca  cttgttttc  attttccca  900
gtttcctta  agggtgtca  gtgagcaag  ctccaaata  tggccctgt  ggtctggat  960
ttcaaagat  gttagtagt  caccccttc  aacagtttg  cctcaagtt  gttggtaca  1020
ttcatgtga  gtcacatgc  catgcaatg  cagccagca  cacttccta  agactttca  1080
cgtttaggt  atatttgtg  atgtgtatg  atatattaa  tatatagta  atatgcata  1140
acattctgt  tatattata  ctatgtatt  agtatgtgt  aatgtgcat  aatatatat  1200
tatatgcat  tatatattt  tatatgttc  cacatgcac  cacatttct  caagaaaag  1260
tgggaaaga  ccttggtgc  caaattgga  tgtgtacac  tgcttgcat  catgttctg  1320
cttctggtc  ttcatactg  gtctgaaca  ggcaaacta  attaactgc  atgcaggct  1380
agaaaggaa  actaacttg  aaaaagtga  ttccgtcaa  ccactgggt  ttgatggag  1440
gttgacgta  ctcgacatt  gagagttcc  ataactgaa  ttcccttat  1489



<210> 8315
<211> 205
<212> PRT
<213> Rattus norvegicus
<308> P49799
<400> 8315

Met Cys Lys Gly Leu Ala Gly Leu Pro Ala Ser Cys Leu Arg Ser Ala 
  1               5                  10                  15
Lys Asp Met Lys His Arg Leu Gly Phe Leu Leu Gln Lys Ser Asp Ser 
             20                  25                  30
Cys Glu His Ser Ser Ser His Ser Lys Lys Asp Lys Val Val Thr Cys 
         35                  40                  45
Gln Arg Val Ser Gln Glu Glu Val Lys Lys Trp Ala Glu Ser Leu Glu 
     50                  55                  60
Asn Leu Ile Asn His Glu Cys Gly Leu Ala Ala Phe Lys Ala Phe Leu 
 65                  70                  75                  80
Lys Ser Glu Tyr Ser Glu Glu Asn Ile Asp Phe Trp Ile Ser Cys Glu 
                 85                  90                  95
Glu Tyr Lys Lys Ile Lys Ser Pro Ser Lys Leu Ser Pro Lys Ala Lys 
             100                105                110
Lys Ile Tyr Asn Glu Phe Ile Ser Val Gln Ala Thr Lys Glu Val Asn 
         115                120                125
Leu Asp Ser Cys Thr Arg Glu Glu Thr Ser Arg Asn Met Leu Glu Pro 
     130                135                140
Thr Ile Thr Cys Phe Asp Glu Ala Gln Lys Lys Ile Phe Asn Leu Met 
 145                150                155                160
Glu Lys Asp Ser Tyr Arg Arg Phe Leu Lys Ser Arg Phe Tyr Leu Asp 
                 165                170                175
Leu Thr Asn Pro Ser Ser Cys Gly Ala Glu Lys Gln Lys Gly Ala Lys 
             180                185                190
Ser Ser Ala Asp Cys Thr Ser Leu Val Pro Gln Cys Ala 
         195                200                205



<210> 8316
<211> 800
<212> DNA
<213> Homo sapiens
<308> U27768
<400> 8316

gcaacatag  acgttcgca  agtacgctc  aagccgaag  cacagctcc  cctgccgca  60
ttctttcct  cttgcgaat  ccaagctgt  aaataagat  tgcaaaggg  ttgcaggtc  120
gccggcttc  tgcttgagg  gtgcaaaag  tatgaaaca  cggctaggt  tcctgctgc  180
aaaatctga  tcctgtgaa  acaattctt  ccacaacaa  aaggacaaa  tggttattt  240
ccagagagt  agccaagag  aagtcaaga  atgggctga  tcactggaa  acctgatta  300
tcatgaatg  gggctggca  ctttcaaag  tttcttgaa  tctgaatat  gtgaggaga  360
tattgactt  tggatcagc  gtgaagagt  caagaaaat  aaatcacca  ctaaactaa  420
tcccaaggc  aaaaagatc  ataatgaat  catctcagt  caggcaacc  aagaggtga  480
cctggattc  tgcaccagg  aagagacaa  ccggaacat  ctagagcct  caataacct  540
ctttgatga  gcccagaag  agattttca  cctgatgga  aaggattcc  accgccgct  600
cctcaagtc  cgattctat  ttgatttgg  caacccgtc  agctgtggg  cagaaaagc  660
gaaaggagc  aagagttca  cagactgtg  ttccctggt  cctcagtgt  cctaattct  720
acctgaagg  agagggatg  aaagccgaa  ctgagatat  catcacact  gggggcgtc  780
agcatgatc  agagggccta  800



<210> 8317
<211> 205
<212> PRT
<213> Homo sapiens
<308> P49798
<400> 8317

Met Cys Lys Gly Leu Ala Gly Leu Pro Ala Ser Cys Leu Arg Ser Ala 
  1               5                  10                  15
Lys Asp Met Lys His Arg Leu Gly Phe Leu Leu Gln Lys Ser Asp Ser 
             20                  25                  30
Cys Glu His Asn Ser Ser His Asn Lys Lys Asp Lys Val Val Ile Cys 
         35                  40                  45
Gln Arg Val Ser Gln Glu Glu Val Lys Lys Trp Ala Glu Ser Leu Glu 
     50                  55                  60
Asn Leu Ile Ser His Glu Cys Gly Leu Ala Ala Phe Lys Ala Phe Leu 
 65                  70                  75                  80
Lys Ser Glu Tyr Ser Glu Glu Asn Ile Asp Phe Trp Ile Ser Cys Glu 
                 85                  90                  95
Glu Tyr Lys Lys Ile Lys Ser Pro Ser Lys Leu Ser Pro Lys Ala Lys 
             100                105                110
Lys Ile Tyr Asn Glu Phe Ile Ser Val Gln Ala Thr Lys Glu Val Asn 
         115                120                125
Leu Asp Ser Cys Thr Arg Glu Glu Thr Ser Arg Asn Met Leu Glu Pro 
     130                135                140
Thr Ile Thr Cys Phe Asp Glu Ala Gln Lys Lys Ile Phe Asn Leu Met 
 145                150                155                160
Glu Lys Asp Ser Tyr Arg Arg Phe Leu Lys Ser Arg Phe Tyr Leu Asp 
                 165                170                175
Leu Val Asn Pro Ser Ser Cys Gly Ala Glu Lys Gln Lys Gly Ala Lys 
             180                185                190
Ser Ser Ala Asp Cys Ala Ser Leu Val Pro Gln Cys Ala 
         195                200                205



<210> 8318
<211> 1489
<212> DNA
<213> Rattus norvegicus
<308> U27767
<400> 8318

atactataa  tatatttta  tgtctatac  cctcgaggt  agctacgtc  acggttaaa  60
aagatgtgc  aaggactcg  tggtctgcc  gcttcctgc  tgaggagcg  aaaggatat  120
aaacatcgg  tgggatttc  gctgcagaa  tcagattcc  gtgaacata  ttcttcaca  180
agcaagaag  acaaagtag  aacttgcca  agggtgagc  aagaagaag  caagaaatg  240
gctgaatcg  tggaaaacc  gattaacca  gaatgtgga  tggcagctt  caaagcttt  300
ctgaagtca  aatacagtg  ggagaacat  gacttctgg  tcagctgtg  ggagtacaa  360
aaaatcaaa  caccttcta  actaagtcc  aaggccaag  agatctaca  tgagttcat  420
tctgtgcag  caacaaaag  ggtgaacct  gattcttgc  ccagagagg  gacaagccg  480
aacatgtta  agcccacga  aacctgttt  gatgaagcc  agaagaaga  tttcaacct  540
atggaaaag  attcatacc  tcgtttcct  aagtctcga  tctatcttg  cctgaccaa  600
ccttccagc  gcggggcag  gaagcagaa  ggagccaag  gttctgcag  ctgcacttc  660
ctagtccct  agtgtgcct  attctcaca  agaggcaga  aaccgaaat  ccaagactc  720
atgctctgg  aaacctgag  ccaaatatt  atctgtatt  agcatcaat  ctttctcca  780
attgtagcc  agtatccat  ctgcctgcc  tgtgtgagt  acttccatg  aaaactaga  840
ttagctgtg  tgtgggggt  ttcattggg  taagaccca  cttgttttc  attttccca  900
gtttcctta  agggtgtca  gtgagcaag  ctccaaata  tggccctgt  ggtctggat  960
ttcaaagat  gttagtagt  caccccttc  aacagtttg  cctcaagtt  gttggtaca  1020
ttcatgtga  gtcacatgc  catgcaatg  cagccagca  cacttccta  agactttca  1080
cgtttaggt  atatttgtg  atgtgtatg  atatattaa  tatatagta  atatgcata  1140
acattctgt  tatattata  ctatgtatt  agtatgtgt  aatgtgcat  aatatatat  1200
tatatgcat  tatatattt  tatatgttc  cacatgcac  cacatttct  caagaaaag  1260
tgggaaaga  ccttggtgc  caaattgga  tgtgtacac  tgcttgcat  catgttctg  1320
cttctggtc  ttcatactg  gtctgaaca  ggcaaacta  attaactgc  atgcaggct  1380
agaaaggaa  actaacttg  aaaaagtga  ttccgtcaa  ccactgggt  ttgatggag  1440
gttgacgta  ctcgacatt  gagagttcc  ataactgaa  ttcccttat  1489



<210> 8319
<211> 205
<212> PRT
<213> Rattus norvegicus
<308> P49799
<400> 8319

Met Cys Lys Gly Leu Ala Gly Leu Pro Ala Ser Cys Leu Arg Ser Ala 
  1               5                  10                  15
Lys Asp Met Lys His Arg Leu Gly Phe Leu Leu Gln Lys Ser Asp Ser 
             20                  25                  30
Cys Glu His Ser Ser Ser His Ser Lys Lys Asp Lys Val Val Thr Cys 
         35                  40                  45
Gln Arg Val Ser Gln Glu Glu Val Lys Lys Trp Ala Glu Ser Leu Glu 
     50                  55                  60
Asn Leu Ile Asn His Glu Cys Gly Leu Ala Ala Phe Lys Ala Phe Leu 
 65                  70                  75                  80
Lys Ser Glu Tyr Ser Glu Glu Asn Ile Asp Phe Trp Ile Ser Cys Glu 
                 85                  90                  95
Glu Tyr Lys Lys Ile Lys Ser Pro Ser Lys Leu Ser Pro Lys Ala Lys 
             100                105                110
Lys Ile Tyr Asn Glu Phe Ile Ser Val Gln Ala Thr Lys Glu Val Asn 
         115                120                125
Leu Asp Ser Cys Thr Arg Glu Glu Thr Ser Arg Asn Met Leu Glu Pro 
     130                135                140
Thr Ile Thr Cys Phe Asp Glu Ala Gln Lys Lys Ile Phe Asn Leu Met 
 145                150                155                160
Glu Lys Asp Ser Tyr Arg Arg Phe Leu Lys Ser Arg Phe Tyr Leu Asp 
                 165                170                175
Leu Thr Asn Pro Ser Ser Cys Gly Ala Glu Lys Gln Lys Gly Ala Lys 
             180                185                190
Ser Ser Ala Asp Cys Thr Ser Leu Val Pro Gln Cys Ala 
         195                200                205



<210> 8320
<211> 800
<212> DNA
<213> Homo sapiens
<308> U27768
<400> 8320

gcaacatag  acgttcgca  agtacgctc  aagccgaag  cacagctcc  cctgccgca  60
ttctttcct  cttgcgaat  ccaagctgt  aaataagat  tgcaaaggg  ttgcaggtc  120
gccggcttc  tgcttgagg  gtgcaaaag  tatgaaaca  cggctaggt  tcctgctgc  180
aaaatctga  tcctgtgaa  acaattctt  ccacaacaa  aaggacaaa  tggttattt  240
ccagagagt  agccaagag  aagtcaaga  atgggctga  tcactggaa  acctgatta  300
tcatgaatg  gggctggca  ctttcaaag  tttcttgaa  tctgaatat  gtgaggaga  360
tattgactt  tggatcagc  gtgaagagt  caagaaaat  aaatcacca  ctaaactaa  420
tcccaaggc  aaaaagatc  ataatgaat  catctcagt  caggcaacc  aagaggtga  480
cctggattc  tgcaccagg  aagagacaa  ccggaacat  ctagagcct  caataacct  540
ctttgatga  gcccagaag  agattttca  cctgatgga  aaggattcc  accgccgct  600
cctcaagtc  cgattctat  ttgatttgg  caacccgtc  agctgtggg  cagaaaagc  660
gaaaggagc  aagagttca  cagactgtg  ttccctggt  cctcagtgt  cctaattct  720
acctgaagg  agagggatg  aaagccgaa  ctgagatat  catcacact  gggggcgtc  780
agcatgatc  agagggccta  800



<210> 8321
<211> 205
<212> PRT
<213> Homo sapiens
<308> P49798
<400> 8321

Met Cys Lys Gly Leu Ala Gly Leu Pro Ala Ser Cys Leu Arg Ser Ala 
  1               5                  10                  15
Lys Asp Met Lys His Arg Leu Gly Phe Leu Leu Gln Lys Ser Asp Ser 
             20                  25                  30
Cys Glu His Asn Ser Ser His Asn Lys Lys Asp Lys Val Val Ile Cys 
         35                  40                  45
Gln Arg Val Ser Gln Glu Glu Val Lys Lys Trp Ala Glu Ser Leu Glu 
     50                  55                  60
Asn Leu Ile Ser His Glu Cys Gly Leu Ala Ala Phe Lys Ala Phe Leu 
 65                  70                  75                  80
Lys Ser Glu Tyr Ser Glu Glu Asn Ile Asp Phe Trp Ile Ser Cys Glu 
                 85                  90                  95
Glu Tyr Lys Lys Ile Lys Ser Pro Ser Lys Leu Ser Pro Lys Ala Lys 
             100                105                110
Lys Ile Tyr Asn Glu Phe Ile Ser Val Gln Ala Thr Lys Glu Val Asn 
         115                120                125
Leu Asp Ser Cys Thr Arg Glu Glu Thr Ser Arg Asn Met Leu Glu Pro 
     130                135                140
Thr Ile Thr Cys Phe Asp Glu Ala Gln Lys Lys Ile Phe Asn Leu Met 
 145                150                155                160
Glu Lys Asp Ser Tyr Arg Arg Phe Leu Lys Ser Arg Phe Tyr Leu Asp 
                 165                170                175
Leu Val Asn Pro Ser Ser Cys Gly Ala Glu Lys Gln Lys Gly Ala Lys 
             180                185                190
Ser Ser Ala Asp Cys Ala Ser Leu Val Pro Gln Cys Ala 
         195                200                205



<210> 8322
<211> 4871
<212> DNA
<213> Rattus norvegicus
<308> U28938
<400> 8322

ttttaagcg  cacggggac  cgctggcgc  gccatccct  ccgggttcc  ggtcgcgcc  60
cgatggggc  cctgcctag  gaaaggcgc  ggggccgcc  cctgctacc  ctgctcggg  120
tctttgtgc  gctcaagat  gtttcaacg  tccacgtga  tgtccgaga  gacaacaac  180
tcgttgtgt  tttagaagc  tctgatgta  tcagcccaa  ctccgtgta  gttgtgagg  240
tagctggcg  atccaaaaa  tatttcttc  aatttgagg  atccaatgg  acactgcct  300
ctcctgtgg  ctttaaggc  acgtatcat  gtctttatt  catcatcag  ctggtggta  360
tcagtggga  tgtggtcac  aaaccatcc  gatcaatca  cgtgctgac  aaacccttg  420
ccgtaacca  tgtgtctat  tatgactat  agccttctc  tgagacagg  gtactgttt  480
aaattcact  tccggaaaa  tacaacgtg  tcagcagag  gaacatcag  tactgggag  540
ggaaggatt  caggacgat  ctgtacaaa  acttcctga  ggggaaaac  gtgtttaat  600
actggctcc  ggggatctg  tacagtaac  tcactttcc  gctggtttc  gaggcgacc  660
ttaacaaaa  caccctggt  gagtgcagt  gtgtgagtc  cgaacccaa  caacacaga  720
cagcgccgt  tccccctcg  aacatctct  ttcgctttg  caacttgaa  aagaacaac  780
gggaagaac  aagcgggag  ttccccgag  actcgttca  caaaccgca  gacgcgata  840
gaagagaca  acccttcca  ttccccgag  aaacccctg  gacgcccgc  agcaatgcg  900
cttccggct  gcctgaccc  aacggcact  agtatgaga  cacatctca  ccctactgg  960
gggacagtg  atccgcggc  cctgaaaac  aggaggact  cgtcagcgt  ctgccagcg  1020
actatgaca  tgaggccac  ctcggcagg  cagagaaac  cacagctga  cctttctct  1080
ccttccccg  gcagatgac  ctgagctgg  taccaccaa  accgcctac  gccttcgat  1140
gcttcaata  cctcataga  agggaaggg  actttaccg  ctatttgac  gtggatgaa  1200
aagcccacg  gtttgttgc  gaactgaag  agcctggaa  gtacagact  tcagtgaca  1260
ccttcagct  ctcgggagc  tgtgagact  ggaaaagcc  gtcagcaaa  tcgctcagc  1320
tctacatca  ccccacagg  gagtggatt  aagaactga  tgagaaacc  cagcacgtg  1380
gtgtccacg  cttaagctc  accactgcc  tgttgtcgt  gacatcttc  caggagaac  1440
acaacagca  cattgtgtc  gtggtgtcc  tgacatgcc  gaaacagaa  gagagccag  1500
ggctggaga  gcagtattg  acccaggtg  actcaagca  acctgtaat  gagaacctg  1560
ttcccggtg  ccagtacca  gttgtgatg  acctaagaa  aggcccttt  attgggcca  1620
cttctgatc  tgtgacatt  gccattgtt  ccacgggga  aaaggattt  atgctctat  1680
cattgggtc  cacggcagt  gtgctgagc  ggacccgac  ttacttggg  gtgttcaga  1740
aatacgtgg  tgaaatgtt  tatttcaac  ccaccacca  gacctccga  tggacgacc  1800
actacgaaa  agcagcgac  gtctcctta  catcgtccg  gagaatagc  aatctattg  1860
cggcgtggt  ctacaactt  cgcgtaacc  tggtgacgt  gggagatcc  gaactgagc  1920
gctgtgaca  ttccaccat  agcttcata  cggcccccg  cgctccaga  atcacgtct  1980
tggagtact  caacagcct  ctgtacatc  gctggacct  cggggacgc  accactgac  2040
tgtcccatt  gagaatgct  cactggatg  tcgtggcag  agggaggag  aaaattaaa  2100
agagtgtga  acgcaatgt  atgacggcc  tccttagcc  gcctccagg  gatatctac  2160
acctgtctg  cacagcctg  actgagagg  ggagtaaca  ctccatgct  cgccttgtc  2220
agctagaac  agctcctcc  aaatcactc  tcgcagtga  caaaacgca  acatcggtc  2280
ccctgcttt  ggttgagga  ggcgtagct  atttctttg  agtcctctg  cagaagctc  2340
ggtctggcc  cgatggcaa  ctccaggaa  cggtagctg  ttcctccca  gtggtgacc  2400
tctccagcc  cctcccagc  actgcctac  actgcagtg  caccagctt  agccacgac  2460
gtcccagtg  ccctacgtt  atagctgtc  ccacaatgg  tacagaggt  aaccctaat  2520
tggtggtga  ctcggtgct  gccatcctc  gcatacttt  aattggact  ctgttagtg  2580
cccttgtca  tctgagaaa  aagcacctg  agatggcca  ggagtgtgg  gctggcacg  2640
ttgtcaatt  tgcatcctt  gagagggaa  ggaaactcc  ctacagttg  cgtaggagt  2700
tctttactt  cttaaccct  ctgccctca  gtctgtgga  tgactatct  ttggcattt  2760
atattaacc  ttggagtaa  aatggctta  agaagagga  actgacgaa  cctgttcag  2820
tggacgatt  tgattctta  atcaaggac  tggccaagg  ctctgacta  aaattctct  2880
ttcagtttg  ggagttgaa  ttgattgga  tggatattc  acactttgc  gcagatctt  2940
cgctgaacc  atgtaaaaa  cgctataca  acatcctgc  gtacgactt  agcagagtg  3000
ggctggtct  catgaatga  gaagaagga  cagactaca  taatgccaa  tatattcct  3060
gctacaact  acctcagga  tacattgcc  cccagggac  actgccgga  accagaaat  3120
atttctgga  gatggtcct  cagcagaag  ctcgcatca  tgtcatgct  actcagtgc  3180
atgagaaaa  aagggtaaa  tgcgaccac  actggccat  cacggaaga  cccattgct  3240
atggagaca  caccgtgga  atggtctct  aggaagaac  ggaggactg  gccagcaga  3300
acttccgga  caattatgc  gacgaggcc  aggatgtga  gcactttaa  tacacggcc  3360
ggccagacc  tggcgtgcc  ccagcaaat  ctgccgaga  catcctgca  ttcgtgtac  3420
ctgtccggc  gcaagccac  aagagcaaa  gacccatga  catccactg  agcgcgggc  3480
tgggacgga  aggcacctt  atagccctt  acaggctct  gcaacacat  cgagatcac  3540
aatttgtgg  catcttggg  ctggtgtca  aaatgcgct  ataccgaat  tcgatggta  3600
agacagagg  gcagtacat  ttcatccat  agtgcgtgc  gctgatgtg  ctgaagaag  3660
agcaacagt  ctgcatcag  gacgtcatc  acgagaacg  cagcaagtc  tagttcaga  3720
tcgggagcg  tgaggccat  atgtctacc  atcctccct  gcttccaga  gttttatag  3780
ggcctttag  cactttgtc  aatcgcgtc  ccgctgcgc  gtttgtgga  aaggaggtg  3840
tttaacctc  tagaaccga  aagacttag  cttaaggag  ctacaatac  gtttggagt  3900
ttttcactt  tagacgttt  atggtccaa  ttcactagg  tttccagaa  tgctcctcc  3960
cgaagggcg  gaagtgccc  tcctgatgg  tcagtcggc  ctttgctgc  tgggctggg  4020
ttggttttt  ctttttttt  agtgcaata  tttctgtat  atcgtgatt  tttttttac  4080
ttcgcaatt  agaatgttg  attgttatc  gcccacatc  ctgatcagt  ccacagcct  4140
gggaaggcc  tatcgcaga  ttttatctc  ccactgaag  ggcatggct  cacacagga  4200
gactcggtg  caaatcctc  aaggaaatg  gcgcgtgtg  ccctccctc  aacctctcg  4260
agctatggg  caggagtag  tgggcagag  gagaagaga  gggttctac  cacacgtca  4320
ccggtttat  tcttcctat  tcgaatatg  gaacctgtg  ttcgaagta  agtaggaaa  4380
acattactt  tctgacttg  cgtagtggg  ttcttcctt  ttgacagtt  ggagtttct  4440
ccgtggctc  tttgaacta  tgtcactgt  atggtcctt  tcaaacagc  agagctgac  4500
caacagttt  gagtctgac  ctgaactct  agaaatctt  gtgcctagc  ttctttatt  4560
ttctgtcca  ccgtgtaca  aagaacagt  tctccaaga  ctataggct  taaaaatgc  4620
ctttctttc  ccacccaga  gagctggga  ttcagaagt  aggacaacg  actcagcat  4680
ctaggacag  cactggaca  cgtccctta  gaataccgt  gagcgtctc  gtggattcc  4740
acaggatat  ctctgggtt  tttgcattt  tgttgtcag  ctcatttta  cccgtgtag  4800
tagtggcat  ttattcttt  gattttgta  gattaaagt  catgattat  tgttgtgac  4860
agcgccgcg  a  4871



<210> 8323
<211> 1217
<212> PRT
<213> Rattus norvegicus
<308> U28938
<400> 8323

Met Gly His Leu Pro Arg Glu Arg Arg Gly Gly Arg Arg Leu Leu Pro 
  1               5                  10                  15
Leu Leu Gly Leu Phe Val Leu Leu Lys Ile Val Ser Thr Phe His Val 
             20                  25                  30
Thr Val Arg Asp Asp Asn Asn Ile Val Val Ser Leu Glu Ala Ser Asp 
         35                  40                  45
Val Val Ser Pro Thr Ser Val Tyr Val Val Arg Val Ala Gly Glu Ser 
     50                  55                  60
Lys Asn Tyr Phe Phe Glu Phe Glu Glu Ser Asn Gly Thr Leu Pro Pro 
 65                  70                  75                  80
Pro Val Val Phe Lys Ala Thr Tyr His Gly Leu Tyr Tyr Ile Ile Ser 
                 85                  90                  95
Leu Val Val Val Ser Gly Asn Val Val Thr Lys Pro Ser Arg Ser Ile 
             100                105                110
Thr Val Leu Thr Lys Pro Leu Pro Val Thr Ser Val Ser Ile Tyr Asp 
         115                120                125
Tyr Lys Pro Ser Pro Glu Thr Gly Val Leu Phe Glu Ile His Tyr Pro 
     130                135                140
Glu Lys Tyr Asn Val Phe Ser Arg Val Asn Ile Ser Tyr Trp Glu Gly 
 145                150                155                160
Lys Asp Phe Arg Thr Met Leu Tyr Lys Asp Phe Leu Lys Gly Lys Thr 
                 165                170                175
Val Phe Asn His Trp Leu Pro Gly Ile Cys Tyr Ser Asn Ile Thr Phe 
             180                185                190
Gln Leu Val Ser Glu Ala Thr Phe Asn Lys Ser Thr Leu Val Glu Cys 
         195                200                205
Ser Gly Val Ser His Glu Pro Lys Gln His Arg Thr Ala Pro Tyr Pro 
     210                215                220
Pro Arg Asn Ile Ser Val Arg Phe Val Asn Leu Asn Lys Asn Asn Trp 
 225                230                235                240
Glu Glu Pro Ser Gly Ser Phe Pro Glu Asp Ser Phe Ile Lys Pro Gln 
                 245                250                255
Asp Ala Ile Gly Arg Asp Arg Pro Phe His Phe Pro Glu Glu Thr Pro 
             260                265                270
Glu Thr Pro Ala Ser Asn Ala Ser Ser Gly Trp Pro Asp Pro Asn Gly 
         275                280                285
Thr Glu Tyr Glu Ser Thr Ser Gln Pro Tyr Trp Trp Asp Ser Ala Ser 
     290                295                300
Ala Ala Pro Glu Asn Glu Glu Asp Phe Val Ser Val Leu Pro Ala Asp 
 305                310                315                320
Tyr Asp Thr Glu Ala Thr Leu Gly Arg Thr Glu Lys Pro Thr Ala Asp 
                 325                330                335
Pro Phe Ser Ala Phe Pro Val Gln Met Thr Leu Ser Trp Leu Pro Pro 
             340                345                350
Lys Pro Pro Thr Ala Phe Asp Gly Phe Asn Ile Leu Ile Glu Arg Glu 
         355                360                365
Gly Asn Phe Thr Asp Tyr Leu Thr Val Asp Glu Glu Ala His Glu Phe 
     370                375                380
Val Ala Glu Leu Lys Glu Pro Gly Lys Tyr Arg Leu Ser Val Thr Thr 
 385                390                395                400
Phe Ser Ser Ser Gly Ala Cys Glu Thr Arg Lys Ser Gln Ser Ala Lys 
                 405                410                415
Ser Leu Ser Phe Tyr Ile Ser Pro Thr Gly Glu Trp Ile Glu Glu Leu 
             420                425                430
Thr Glu Lys Pro Gln His Val Ser Val His Val Leu Ser Ser Thr Thr 
         435                440                445
Ala Leu Leu Ser Trp Thr Ser Ser Gln Glu Asn Tyr Asn Ser Thr Ile 
     450                455                460
Val Ser Val Val Ser Leu Thr Cys Gln Lys Gln Lys Glu Ser Gln Arg 
 465                470                475                480
Leu Glu Lys Gln Tyr Cys Thr Gln Val Asn Ser Ser Lys Pro Val Ile 
                 485                490                495
Glu Asn Leu Val Pro Gly Ala Gln Tyr Gln Val Val Met Tyr Leu Arg 
             500                505                510
Lys Gly Pro Leu Ile Gly Pro Pro Ser Asp Pro Val Thr Phe Ala Ile 
         515                520                525
Val Pro Thr Gly Ile Lys Asp Leu Met Leu Tyr Pro Leu Gly Pro Thr 
     530                535                540
Ala Val Val Leu Ser Trp Thr Arg Pro Tyr Leu Gly Val Phe Arg Lys 
 545                550                555                560
Tyr Val Val Glu Met Phe Tyr Phe Asn Pro Thr Thr Met Thr Ser Glu 
                 565                570                575
Trp Thr Thr Tyr Tyr Glu Ile Ala Ala Thr Val Ser Leu Thr Ser Ser 
             580                585                590
Val Arg Ile Ala Asn Leu Leu Pro Ala Trp Tyr Tyr Asn Phe Arg Val 
         595                600                605
Thr Met Val Thr Trp Gly Asp Pro Glu Leu Ser Cys Cys Asp Ser Ser 
     610                615                620
Thr Ile Ser Phe Ile Thr Ala Pro Val Ala Pro Glu Ile Thr Ser Val 
 625                630                635                640
Glu Tyr Phe Asn Ser Leu Leu Tyr Ile Ser Trp Thr Tyr Gly Asp Ala 
                 645                650                655
Thr Thr Asp Leu Ser His Ser Arg Met Leu His Trp Met Val Val Ala 
             660                665                670
Glu Gly Arg Arg Lys Ile Lys Lys Ser Val Thr Arg Asn Val Met Thr 
         675                680                685
Ala Ile Leu Ser Leu Pro Pro Gly Asp Ile Tyr Asn Leu Ser Val Thr 
     690                695                700
Ala Cys Thr Glu Arg Gly Ser Asn Thr Ser Met Leu Arg Leu Val Lys 
 705                710                715                720
Leu Glu Pro Ala Pro Pro Lys Ser Leu Phe Ala Val Asn Lys Thr Gln 
                 725                730                735
Thr Ser Val Thr Leu Leu Trp Val Glu Glu Gly Val Ala Asp Phe Phe 
             740                745                750
Glu Val Leu Cys Gln Lys Leu Gly Ser Gly His Asp Gly Lys Leu Gln 
         755                760                765
Glu Pro Val Ala Val Ser Ser His Val Val Thr Ile Ser Ser Leu Leu 
     770                775                780
Pro Ala Thr Ala Tyr Asn Cys Ser Val Thr Ser Phe Ser His Asp Ser 
 785                790                795                800
Pro Ser Val Pro Thr Phe Ile Ala Val Ser Thr Met Val Thr Glu Val 
                 805                810                815
Asn Pro Asn Val Val Val Ile Ser Val Leu Ala Ile Leu Ser Ile Leu 
             820                825                830
Leu Ile Gly Leu Leu Leu Val Thr Leu Val Ile Leu Arg Lys Lys His 
         835                840                845
Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr Phe Val Asn Phe Ala 
     850                855                860
Ser Leu Glu Arg Glu Gly Lys Leu Pro Tyr Ser Trp Arg Arg Ser Val 
 865                870                875                880
Phe Thr Phe Leu Thr Leu Leu Pro Ser Cys Leu Trp Thr Asp Tyr Leu 
                 885                890                895
Leu Ala Phe Tyr Ile Asn Pro Trp Ser Lys Asn Gly Leu Lys Lys Arg 
             900                905                910
Lys Leu Thr Asn Pro Val Gln Leu Asp Asp Phe Asp Ser Tyr Ile Lys 
         915                920                925
Asp Met Ala Lys Asp Ser Asp Tyr Lys Phe Ser Leu Gln Phe Glu Glu 
     930                935                940
Leu Lys Leu Ile Gly Leu Asp Ile Pro His Phe Ala Ala Asp Leu Pro 
 945                950                955                960
Leu Asn Arg Cys Lys Asn Arg Tyr Thr Asn Ile Leu Pro Tyr Asp Phe 
                 965                970                975
Ser Arg Val Arg Leu Val Ser Met Asn Glu Glu Glu Gly Ala Asp Tyr 
             980                985                990
Ile Asn Ala Asn Tyr Ile Pro Gly Tyr Asn Ser Pro Gln Glu Tyr Ile 
         995                1000                1005
Ala Thr Gln Gly Pro Leu Pro Glu Thr Arg Asn Asp Phe Trp Lys Met 
     1010                1015                1020
Val Leu Gln Gln Lys Ser Arg Ile Ile Val Met Leu Thr Gln Cys Asn 
 1025                1030                1035                1040
Glu Lys Arg Arg Val Lys Cys Asp His Tyr Trp Pro Phe Thr Glu Glu 
                 1045                1050                1055
Pro Ile Ala Tyr Gly Asp Ile Thr Val Glu Met Val Ser Glu Glu Glu 
             1060                1065                1070
Gln Glu Asp Trp Ala Ser Arg His Phe Arg Ile Asn Tyr Ala Asp Glu 
         1075                1080                1085
Ala Gln Asp Val Met His Phe Asn Tyr Thr Ala Trp Pro Asp His Gly 
     1090                1095                1100
Val Pro Pro Ala Asn Ala Ala Glu Ser Ile Leu Gln Phe Val Tyr Thr 
 1105                1110                1115                1120
Val Arg Gln Gln Ala Thr Lys Ser Lys Gly Pro Met Ile Ile His Cys 
                 1125                1130                1135
Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Ala Leu Asp Arg Leu 
             1140                1145                1150
Leu Gln His Ile Arg Asp His Glu Phe Val Asp Ile Leu Gly Leu Val 
         1155                1160                1165
Ser Glu Met Arg Ser Tyr Arg Met Ser Met Val Gln Thr Glu Glu Gln 
     1170                1175                1180
Tyr Ile Phe Ile His Gln Cys Val Gln Leu Met Trp Leu Lys Lys Lys 
 1185                1190                1195                1200
Gln Gln Phe Cys Ile Ser Asp Val Ile Tyr Glu Asn Val Ser Lys Ser 
                 1205                1210                1215
Ter 
             1220



<210> 8324
<211> 3979
<212> DNA
<213> Homo sapiens
<308> AF187042
<400> 8324

aagtaaaaa  atggaaggg  gaaaaggca  agtattctg  cttccaagt  agatagcta  60
ctttatgaa  ggacatatt  caaaggcaa  ataaagtct  tatggtgct  ttacctacc  120
atatttgaa  tgggggatg  ttcacctgc  tattagtga  agaagaaag  atacactta  180
taaattaaa  tttttttaa  actttgtct  tgctcagaa  cagctccac  caaatcact  240
ttcgcagtg  acaaaaccc  gacttcagt  actttgctg  gggtggaag  gggagtagc  300
gatttcttt  aagttttct  tcaacaagt  ggctccagt  agaaaacca  acttcagga  360
ccagttgct  tttcttccc  tgtcgtgac  atctccagc  ttcttcctg  cactgccta  420
aattgtagt  tcaccagct  tagccatga  agccccagt  tccctacgt  catagccgt  480
tcaacaatg  ttacagaga  gaatcccaa  gtggtagtg  tctccgtgc  ggccatcct  540
agcacactt  taattggac  gttgcttgt  accctcatt  ttcttagga  aaagcatct  600
cagatggct  gggagtgtg  agctggtac  tttgtcaat  ttgcatcct  agagaggga  660
ggaaagctt  catacaact  gagtaaaaa  ggtttaaag  agaggaaac  gacaaaccc  720
gttcaactg  atgactttg  tgcctatat  aaggatatg  ccaaagact  tgactataa  780
ttttctctt  agtttgagg  gttgaaatt  attggactg  atatcccac  ctttgctgc  840
gatcttcca  tgaatcgat  taaaaaccg  tacacaaac  tcctaccat  tgacttcag  900
cgtgtgaga  tagtctcca  gaatgaaga  gaaggtgca  actacatca  tgccaacta  960
attcctgga  acaactcac  ccaggagta  attgccacc  aggggccac  gcctgaaac  1020
agaaatgac  tctggaaga  ggtcctgca  caaaagtct  agattattg  catgctcac  1080
cagtgtaat  agaaaagga  ggtgaaatg  gaccattac  ggccattca  ggaagaacc  1140
atagcctat  gagacatca  tgtggagat  atttcagag  aagagcagg  cgactgggc  1200
tgtagacac  tccggatca  ctatgctga  gagatgcag  atgtgatgc  ttttaacta  1260
actgcatgg  ctgatcatg  tgtgcccac  gcaaatgct  cagaaagta  cctgcagtt  1320
gtacacatg  tccgacagc  agctaccaa  agcaaaggt  ccatgatca  tcactgcag  1380
gctggcgtg  gacggacag  aacattcat  gccctggac  ggctcttgc  gcacattcg  1440
gatcatgag  ttgttgaca  cttagggct  gtgtcagaa  tgaggtcat  ccggatgtc  1500
atggtacag  cagaggagc  gtacatttt  atccatcag  gtgtgcaac  gatgtggat  1560
aagaagaag  agcagttct  catcagtga  gtcatatac  agaatgtta  caagtccta  1620
ttcagaatc  ggagcagta  gtggagaag  gctctccac  agtgttcag  cttagaact  1680
ttagagggg  atgtgatgg  tgggacaaa  gacagcagt  gccatttgt  ttgactctg  1740
cttcacatg  gtatttctt  ccagctcct  gcctcacat  ggtggtcac  gggagaaac  1800
agtactgta  cagatcttt  agtttcaat  caccttggt  ggtgttggc  acaaacagg  1860
gcttctgca  atcatgatg  ctttacctc  attccctct  cccagaacc  taaattatt  1920
tgttattgg  tctgtgcct  taatatcag  atactacca  ccaaatcta  ctagatatc  1980
tgtgcaaat  ttttattga  tacaagggc  gtatacggg  ttacaaaaa  acatgagct  2040
gattggaca  tcctaaaac  aaaaacaac  gtgacaata  agtctcagg  tagcagagt  2100
tgaaaatac  ttggtctcc  ccattatgt  agcccttat  tgagagctt  atgaagaca  2160
ttgtaacat  ttcaacgtc  tgtactcca  ttttgacta  gagatcaga  tttggaggt  2220
taagtaatc  tggctgagg  aacagtaat  tgcccattt  gttcagtaa  cagactgta  2280
agtgtctga  tatactggg  gaagaggag  caatgacag  gtagggaga  gacagtggt  2340
catgatggg  gaatcatga  agtctggga  gcatatgga  cagtgggaa  gataggatt  2400
gcactgcac  tctacatcc  tcaagagag  cagagcgca  aatggagca  gaaggataa  2460
aaataaaga  agacagaga  aaacaaatt  gctgggaga  ggaaagaca  tcagaccca  2520
agaaaggag  cagcacaca  agaaagatg  acagatcaa  ccacatctg  atgggttgt  2580
agactgagc  tagtgagag  agtggtgga  caatagaag  ttgctgtga  accaggctg  2640
ttactgtct  tctttgtct  attcacagg  gaggacatg  tgtgcgccc  tcctccctt  2700
cttccagat  gttttagtg  gccctgatg  tcatttttc  aaacagagg  cctgctttg  2760
aatatgtgg  caaggagat  atttatctc  cagaagcac  gggaagact  agccttaaa  2820
agcctacag  gtccttttg  actctttca  ttcgggaca  ttaataatg  accaaattc  2880
acagaacac  aggaaggtc  agacgctct  caaagggca  gaagtacag  acttccgaa  2940
agtttagtt  gccctttgc  ggttgggct  agtttttta  ttttaagtg  ttgtttttc  3000
gtgcaataa  ttttgtgtg  gtgtgattc  tatcagaaa  ttgaattgt  ttctgccta  3060
accgttcat  agccccata  cccaggaag  aacaggcat  gttagcatc  gattatacc  3120
cattattaa  aggaggcat  gccacacat  aagaaatgg  cattctact  caaagaaat  3180
gagccagca  tatctgtac  ccaacatta  cggatctgg  ttgggggag  ttggtcagg  3240
aagagaggg  ttctaccca  agatcaact  tgtaatctt  tactattca  gctataatt  3300
agcttcaaa  tagagtaga  aaaaaattg  cttaactgt  ctagttctt  atggttttc  3360
tccttatta  cagttggtg  ttcttcctt  gcccttttg  actaatgtt  ctgtccaag  3420
tctttctca  gaaaccaca  ctggttcag  agagtgtca  gttggactc  ttgaactct  3480
ttgctgtct  agcaatcgt  gtgcctaga  tttgcattc  ttgttctgt  gacctgcat  3540
catgtgaga  ctatttctt  aagaactat  taggctgtg  aaacgcact  tctttcccc  3600
aaagagctg  gaatttatg  agttatggc  atgaactgc  gcatgctgg  acaattatt  3660
gactacttt  ttttgtaat  ttgtcaaat  tctctatgg  ttctgacag  gatttcttt  3720
tgttttgtt  ttcttttgg  tgtcagttt  attttaacg  gtgtaacta  taacatttt  3780
ttctttgga  tttgtataa  tacagtaca  gattgtgta  tgtgacatg  atgctgtca  3840
aatgacatt  atggcattg  gaagcctgt  actttgtgt  acttcctga  aaataagag  3900
tgatgacat  gatatacaa  agaaaacac  ttgagttga  agtaaacac  agctggctg  3960
ttccctgtg  caactgtgg  3979



<210> 8325
<211> 378
<212> PRT
<213> Homo sapiens
<308> AF187042
<400> 8325

Met Val Thr Glu Met Asn Pro Asn Val Val Val Ile Ser Val Leu Ala 
  1               5                  10                  15
Ile Leu Ser Thr Leu Leu Ile Gly Leu Leu Leu Val Thr Leu Ile Ile 
             20                  25                  30
Leu Arg Lys Lys His Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr 
         35                  40                  45
Phe Val Asn Phe Ala Ser Leu Glu Arg Asp Gly Lys Leu Pro Tyr Asn 
     50                  55                  60
Trp Ser Lys Asn Gly Leu Lys Lys Arg Lys Leu Thr Asn Pro Val Gln 
 65                  70                  75                  80
Leu Asp Asp Phe Asp Ala Tyr Ile Lys Asp Met Ala Lys Asp Ser Asp 
                 85                  90                  95
Tyr Lys Phe Ser Leu Gln Phe Glu Glu Leu Lys Leu Ile Gly Leu Asp 
             100                105                110
Ile Pro His Phe Ala Ala Asp Leu Pro Leu Asn Arg Cys Lys Asn Arg 
         115                120                125
Tyr Thr Asn Ile Leu Pro Tyr Asp Phe Ser Arg Val Arg Leu Val Ser 
     130                135                140
Met Asn Glu Glu Glu Gly Ala Asp Tyr Ile Asn Ala Asn Tyr Ile Pro 
 145                150                155                160
Gly Tyr Asn Ser Pro Gln Glu Tyr Ile Ala Thr Gln Gly Pro Leu Pro 
                 165                170                175
Glu Thr Arg Asn Asp Phe Trp Lys Met Val Leu Gln Gln Lys Ser Gln 
             180                185                190
Ile Ile Val Met Leu Thr Gln Cys Asn Glu Lys Arg Arg Val Lys Cys 
         195                200                205
Asp His Tyr Trp Pro Phe Thr Glu Glu Pro Ile Ala Tyr Gly Asp Ile 
     210                215                220
Thr Val Glu Met Ile Ser Glu Glu Glu Gln Asp Asp Trp Ala Cys Arg 
 225                230                235                240
His Phe Arg Ile Asn Tyr Ala Asp Glu Met Gln Asp Val Met His Phe 
                 245                250                255
Asn Tyr Thr Ala Trp Pro Asp His Gly Val Pro Thr Ala Asn Ala Ala 
             260                265                270
Glu Ser Ile Leu Gln Phe Val His Met Val Arg Gln Gln Ala Thr Lys 
         275                280                285
Ser Lys Gly Pro Met Ile Ile His Cys Ser Ala Gly Val Gly Arg Thr 
     290                295                300
Gly Thr Phe Ile Ala Leu Asp Arg Leu Leu Gln His Ile Arg Asp His 
 305                310                315                320
Glu Phe Val Asp Ile Leu Gly Leu Val Ser Glu Met Arg Ser Tyr Arg 
                 325                330                335
Met Ser Met Val Gln Thr Glu Glu Gln Tyr Ile Phe Ile His Gln Cys 
             340                345                350
Val Gln Leu Met Trp Met Lys Lys Lys Gln Gln Phe Cys Ile Ser Asp 
         355                360                365
Val Ile Tyr Glu Asn Val Ser Lys Ser Ter 
     370                375



<210> 8326
<211> 2026
<212> DNA
<213> Rattus norvegicus
<308> U30788
<400> 8326

ggcacgagg  gaggccatc  cttagtccg  tcctagttc  cagtggctg  ctcttgcag  60
ccttcaacc  ggataggct  ctgcatagc  atttcccga  ccactttat  tgctttgtt  120
ctgcccaat  ccactgaat  tcttacgcc  cctgatatc  tgagcaatg  atagtactc  180
cagttgttg  cttcaccag  gcatccaag  gatggcaaa  gcatctgca  tgctgatgt  240
ctggggggg  gtagaggtt  agccatccc  gatgacatt  tgttgtcca  catggcagc  300
cccacctat  tctgacctt  atgaagaga  ctgttcccg  ctgtggaca  ggtagcctc  360
gctttcagc  ggggtcaat  agccagtcg  agaggtctt  cctccaccc  tgggcttct  420
ccagtgctt  acactcgtg  tgtggtggc  ccaggtcag  attgggcag  aaggtgacc  480
gattgcccc  aacaggtgg  gaatctagt  catggcagc  gaccagtgg  ccatctttt  540
ggacactct  ttcaaaggc  gaacatcag  cactctatc  cagtttaag  cctggattg  600
gtgataatt  ttagtgccc  gttggcagg  gtgatgtgt  ccaggcaga  caggactaa  660
tcacacatc  cccagcatc  ggtactggt  cactgagac  ggtcttaag  tccacatac  720
cagtctgta  atatgcata  acatggcct  acccagcca  ttcagccca  gcaagccat  780
ttggagagc  attttctca  gagcaaggg  taggggcag  cacccatga  tatgaacta  840
tgggttacc  ggcccacgc  aaggtccac  gttcttcgg  cagtccata  gtattgttt  900
ttgccagat  ccccttgca  tcaaggtct  tggatattg  cccactggg  ggcatagga  960
cacagagca  tgggtccct  catccacac  tcccttcta  tctctgtac  tagccagca  1020
tctaggacc  agaggctct  cagtgtcct  tcttgttct  ttctggggc  gtccctgac  1080
cagtgtcct  ccgtccctc  agacaccag  agttccgcc  ctgaacgga  gtcttagct  1140
gcgagtcac  gagttcata  ttctgcgca  gcgccctga  cctgtctct  gcttggctc  1200
tgcggcgag  ccgccctgc  gtcatggct  ctccagccc  tgctgtgcc  ctttgcatt  1260
tgcgccggg  tccggctct  cccgcttgg  gtgctactg  gagccggag  atggtggag  1320
ctgggaccg  gacgatttc  acctctatg  gacggacgc  cggagctct  gagcacctg  1380
ttctcgcct  acagcctgg  gatcgctca  agcccgatt  ggcctaagt  ggactgagg  1440
tatccattc  cggttcagg  cagcctgcc  acagcaggc  gtgactgta  gactgtcaa  1500
aggacagag  attgatgac  tttcagggg  tacctctgc  ctggccttt  acctctcca  1560
ggtgcccag  ccagagcag  cccccaggc  gcaggcttt  actctcagc  tggcagagc  1620
tgtatgcaa  ctggagagg  ggctggcag  cacagaaga  accgccatt  gccccagga  1680
gagcaccca  ccagcaggc  ctcagttct  accagaact  gatcaccag  gaggcagct  1740
tgggtctgg  gtcaggaga  ggtgtccag  ggagtctct  gtcaaccct  gtttcaaaa  1800
taagaaacc  gctggtggt  tagacttcg  tgagacctg  agctagcaa  gcctgtgtg  1860
ccttgccag  agtctgtct  caaggaaag  ggacatcat  gacccctaa  cagagacac  1920
ctttgcttc  cttcccctg  ggtcctgct  atgggcaaa  gtacctctc  tcccttccc  1980
atcaaataa  ctgctccct  ggggagaga  gctaggcca  aaaaaa  2026



<210> 8327
<211> 860
<212> DNA
<213> Homo sapiens
<308> BC002613
<400> 8327

ggcacgagg  gccgggttc  cgctcgccc  gcgccatgg  tccgctgtc  ccgccgctc  60
gcacgctgc  gccgggccc  gagccgccc  gcttcgtgt  ctactgcga  ggggaggaa  120
gcggggagg  ggaccgcgg  ggcttcaac  tctacgtga  cgacgccgc  gagctttgg  180
gcacctgct  cacgccgga  agcctggcg  ccctcaaag  ccgttttgg  ctgagtgcg  240
ctgaggaca  caccccccg  ttcagggca  cctgtgagc  gcaagctgt  gctctgact  300
tgcaggagg  cagagcatc  ctgacgctt  caggggggc  ctcggcact  gcctttgac  360
tctccaagg  accaggccc  gaggcagcc  ccaggctgc  ggcgctgac  ctgggcctg  420
caaaacgcg  gtggagcct  gagcggcga  tggcagctg  agaagagac  gctgtcagc  480
cgaggaaga  cccccggcc  gcagggcct  agctcttct  accagaccc  gatccccag  540
gaggtggcc  tggacctgg  gtcaggagg  ggtgtccag  agagtcgct  atcaacccc  600
ggttcaaga  taagaaacc  gctggtggc  tggacttcg  tgagacctg  aggtgcagc  660
caagcgtgg  cccgcgggg  gtccgccta  gaggggaga  gcagtcttt  aggccccca  720
cagagaccc  ccgccacca  ctccacctg  ctgtcctgg  ccaggacta  cacggctcc  780
caaattcct  ccctgtcaa  taaacagct  ccttggttg  aaaaaaaaa  aaaaaaaaa  840
aaaaaaaaa  aaaaaaaaaa  860



<210> 8328
<211> 3738
<212> DNA
<213> Rattus norvegicus
<308> U30938
<400> 8328

tgaatcctt  tcatctagc  ctgaagtac  atttaggca  gagctcttg  caggagtgg  60
ctctgagca  gtgtcatat  cattcttta  aaaccatag  taaataatc  catccccca  120
ctgtagtaa  tgttacaat  ttatataaa  aaaaagaat  gtatatgca  aaaatgacc  180
gaattccat  cgcaacaag  gcacatggc  ttacatgga  acaattgga  aattatttt  240
gctctgctc  gttttgcat  gagtattat  attattatt  tttttaaaa  tgcattttt  300
cctttcatg  gcctgaagg  tatccaata  attctgaaa  gccttgtta  aaatccaag  360
tgctcattt  cctattctg  ttatggttg  aaagattaa  aactatcca  tgtcgctta  420
tacaggttc  aggaaatca  ggagtctga  tgcaggaag  aaagagcat  taagagaca  480
attttttaa  gtgttattt  gtataaatg  gaagaaaga  gcaactaag  tattgatgt  540
tgggacctg  atgattata  cagagtatg  cgttccaat  aattattta  ctaaaagct  600
gattaaagc  tgtgagcgg  gtttgaaga  gtggtgtgg  agtgcgtct  ttaggattg  660
tgcactttc  ttaggatgg  ctcgagtct  attagaatg  cagttgatt  gctagattt  720
tgtccacac  gtcagtttc  tgcccccat  ccatctgtt  gatacagta  tatagatat  780
aatatatat  tatatttct  tgtggccat  tgtgatact  cctcatata  ttgaatatg  840
tacttcttt  ttcacagta  ctgtgtctc  tgcaccctt  ggtgttgca  ttttaggta  900
gtgaaagta  atgttagca  ggttctctc  ctatttaaa  atacatttt  caaagacaa  960
gagtttgag  atgaagttg  tttctgtaa  aactcaaag  tgtaaccct  ttttagtgc  1020
agaatcaag  ccttcctgt  atgctagaa  attttattt  tctttgctt  caccaacat  1080
gagtttgtg  agtgggtcc  gttatgcat  aaggggttt  cagattgtt  gtctatgga  1140
ttatctcat  tttaattac  gaatagttt  ggttttatc  ctctaatta  tcatgaaac  1200
aatccctta  tattcattt  ttctctttc  cttttcctt  ttccatttg  taaagttga  1260
agtaggaaa  tagttttgg  tatcttttc  tgttctcca  atagtatct  ttcattaaa  1320
aattctctg  tagaagata  ttggcttcc  tctcccaaa  acctcttca  aaatgagaa  1380
tacaacata  taagaatat  tatatatat  tatatatat  tattctttg  gacacagat  1440
tctaaatcc  tctctccag  attctacat  aacatggta  gattttttt  attttatat  1500
cagtctcaa  atcacaatt  attaatttc  tttacaaat  atactaagt  aataagcaa  1560
agtcaatgg  ccaaaagaa  acaaagcat  atcaaacca  gtggacttt  cccttaaca  1620
ttaatttgt  ctttttctt  ttctcagga  tggtagact  aatctgaag  gttaaatgt  1680
aaaagttgg  taggtgttt  atgtctttg  aacaagcca  gccctgtct  taaaggaga  1740
ggtgaacat  aacaagaca  agacgtaca  gtgtgtctg  gacagaagg  aagtggatg  1800
gaaggcaga  aggaaacag  tggcagttt  gtgatccat  gagtattat  gccaatgtg  1860
cagccacat  gaaagctta  catcaaacg  agacattct  cacagctag  aggtacaca  1920
acagacaca  acacagaca  acacacaca  acacacaca  acacacaca  acacacaca  1980
agagagaga  agagagaga  acacacaca  acacagaga  agagagaga  acacacaca  2040
acagagaga  agagagaga  acagagaga  agagagaga  acacacacg  ctttgtaaa  2100
tgttttttt  atatataac  ttaaaacta  catgtaatg  ttgctttca  tctggacaa  2160
ccattcctt  cctactctt  aatgcacaa  aaatggaag  aggaacgtc  gtgtgtgga  2220
aaggccagt  ctacagttt  ggtagacaa  gattaaagt  atctaggaa  aagagagtt  2280
atagatgat  cgtgtggtt  aaactatgt  gaagtaatt  caacccagt  tattataaa  2340
attaaggct  agcaaaggt  tttttaagt  ttcaagttc  ttttcttac  atgtgtatt  2400
aaaataaaa  tatgtaagc  ccaagttaa  agatctagc  ctaaaatat  atttttcta  2460
tgttaatac  attataatg  atacaagtc  ttgttctat  tgaaaatgt  attcacaca  2520
gaatgtaaa  tcaacacaa  aaggacctg  attttttgt  ccagacaga  acagagaaa  2580
gcacaggct  aaattcact  ccttatggg  atgtgggat  gatcccacc  tacctactt  2640
agataatga  tcaaattaa  ctttttgga  accactttt  tggggatac  catacgctg  2700
tctagaaat  aaaggcgca  agctacatt  ctagatcca  taatgccag  ttctctttg  2760
cttcagcct  tgagaacct  ttcaagaat  cgtaagtat  cagagctct  aagagttcg  2820
aggccaact  tttcagtga  ctcacacac  ctgggtctc  tgcaactga  aattgggta  2880
cttgcaaca  tgcgggaag  atccgagtt  atgatgagt  tcaaaggcc  tgttcactt  2940
ggaactgac  ctctctgga  ctgcctgct  cgttccagc  agatgacgg  ctgaaatcc  3000
acccatagg  agacacctg  gcaattcca  ctcagtttg  ctgaaggta  ctaaagaag  3060
aggtccagt  aatggaaga  tagactaca  ctggccttc  ccacacaca  acgcacaca  3120
acgcacgca  gcacacaca  agatgtggg  tagaagaga  atcagcacc  aaatgtagc  3180
ttatatcag  agtagtaaa  aaataatat  aatgtgaat  attctgact  agctgcatt  3240
atagttttc  tctcatttt  catgccaca  ggggaaaaa  ataaattat  tatagtaga  3300
gtagcaagg  aaaagtaga  ttatcattt  gaaaggcaa  tttcaggca  ttcttcaag  3360
ctggtgtgc  aaaattaat  ctgttgttg  gtttttaca  ctagaagtt  tagcctgga  3420
atgtagatt  aggccaagt  cctatgtag  aaaaagttt  tttcaaaac  cctaaaaaa  3480
tgccaatca  gaaagtcca  ttcaacttt  gcaaaaaaa  tcaacaaaa  gtatactct  3540
tatgctggg  tcccaaggt  ccaacacac  atctttggg  gggttcttt  ttctgataa  3600
tctagagcc  gttaccata  aaaggaatt  cttcaatgg  tgattgtag  tagttcatg  3660
ttttcaatc  atttgcaaa  gtatttgtt  ctgtatagt  attgttttg  aaaataaaa  3720
tgcttgtca  ctaactac  3738



<210> 8329
<211> 1861
<212> PRT
<213> Rattus norvegicus
<308> P15146
<400> 8329

Met Ala Asp Glu Arg Lys Asp Glu Gly Lys Ala Pro His Trp Thr Ser 
  1               5                  10                  15
Ala Ser Leu Thr Glu Ala Ala Ala His Pro His Ser Pro Glu Met Lys 
             20                  25                  30
Asp Gln Gly Gly Ser Gly Glu Gly Leu Ser Arg Ser Ala Asn Gly Phe 
         35                  40                  45
Pro Tyr Arg Glu Glu Glu Glu Gly Ala Phe Gly Glu His Gly Ser Gln 
     50                  55                  60
Gly Thr Tyr Ser Asp Thr Lys Glu Asn Gly Ile Asn Gly Glu Leu Thr 
 65                  70                  75                  80
Ser Ala Asp Arg Glu Thr Ala Glu Glu Val Ser Ala Arg Ile Val Gln 
                 85                  90                  95
Val Val Thr Ala Glu Ala Val Ala Val Leu Lys Gly Glu Gln Glu Lys 
             100                105                110
Glu Ala Gln His Lys Asp Gln Pro Ala Ala Leu Pro Leu Ala Ala Glu 
         115                120                125
Glu Thr Val Asn Leu Pro Pro Ser Pro Pro Pro Ser Pro Ala Ser Glu 
     130                135                140
Gln Thr Ala Ala Leu Glu Glu Asp Leu Leu Thr Ala Ser Lys Met Glu 
 145                150                155                160
Phe Pro Glu Gln Gln Lys Leu Pro Ser Ser Phe Ala Glu Pro Leu Asp 
                 165                170                175
Lys Glu Glu Thr Glu Phe Lys Met Gln Ser Lys Pro Gly Glu Asp Phe 
             180                185                190
Glu His Ala Ala Leu Val Pro Gln Pro Asp Thr Ser Lys Thr Pro Gln 
         195                200                205
Asp Lys Lys Asp Pro Gln Asp Met Glu Gly Glu Lys Ser Pro Ala Ser 
     210                215                220
Pro Phe Ala Gln Thr Phe Gly Thr Asn Leu Glu Asp Ile Lys Gln Ile 
 225                230                235                240
Thr Glu Pro Ser Ile Thr Val Pro Ser Ile Gly Leu Ser Ala Glu Pro 
                 245                250                255
Leu Ala Pro Lys Asp Gln Lys Asp Trp Phe Ile Glu Met Pro Val Glu 
             260                265                270
Ser Lys Lys Asp Glu Trp Gly Leu Ala Ala Pro Ile Ser Pro Gly Pro 
         275                280                285
Leu Thr Pro Met Arg Glu Lys Asp Val Leu Glu Asp Ile Pro Arg Trp 
     290                295                300
Glu Gly Lys Gln Phe Asp Ser Pro Met Pro Ser Pro Phe His Gly Gly 
 305                310                315                320
Ser Phe Thr Leu Pro Leu Asp Thr Val Lys Asp Glu Arg Val Thr Glu 
                 325                330                335
Gly Ser Gln Pro Phe Ala Pro Val Phe Phe Gln Ser Asp Asp Lys Met 
             340                345                350
Ser Leu Gln Asp Thr Ser Gly Ser Ala Thr Ser Lys Glu Ser Ser Lys 
         355                360                365
Asp Glu Glu Pro Gln Lys Asp Lys Ala Asp Lys Val Ala Asp Val Pro 
     370                375                380
Val Ser Glu Ala Thr Thr Val Leu Gly Asp Val His Ser Pro Ala Val 
 385                390                395                400
Glu Gly Phe Val Gly Glu Asn Ile Ser Gly Glu Glu Lys Gly Thr Thr 
                 405                410                415
Asp Gln Glu Lys Lys Glu Thr Ser Thr Pro Ser Val Gln Glu Pro Thr 
             420                425                430
Leu Thr Glu Thr Glu Pro Gln Thr Lys Leu Glu Glu Thr Ser Lys Val 
         435                440                445
Ser Ile Glu Glu Thr Val Ala Lys Glu Glu Glu Ser Leu Lys Leu Lys 
     450                455                460
Asp Asp Lys Ala Gly Val Ile Gln Thr Ser Thr Glu Gln Ser Phe Ser 
 465                470                475                480
Lys Glu Asp Gln Lys Gly Gln Glu Gln Thr Ile Glu Ala Leu Lys Gln 
                 485                490                495
Asp Ser Phe Pro Ile Ser Leu Glu Gln Ala Val Thr Asp Ala Ala Met 
             500                505                510
Ala Thr Lys Thr Leu Glu Lys Val Thr Ser Glu Pro Glu Ala Val Ser 
         515                520                525
Glu Lys Arg Glu Ile Gln Gly Leu Phe Glu Glu Asp Ile Ala Asp Lys 
     530                535                540
Ser Lys Leu Glu Gly Ala Gly Ser Ala Thr Val Ala Glu Val Glu Met 
 545                550                555                560
Pro Phe Tyr Glu Asp Lys Ser Gly Met Ser Lys Tyr Phe Glu Thr Ser 
                 565                570                575
Ala Leu Lys Glu Asp Val Thr Arg Ser Thr Gly Leu Gly Ser Asp Tyr 
             580                585                590
Tyr Glu Leu Ser Asp Ser Arg Gly Asn Ala Gln Glu Ser Leu Asp Thr 
         595                600                605
Val Ser Pro Lys Asn Gln Gln Asp Glu Lys Glu Leu Leu Ala Lys Ala 
     610                615                620
Ser Gln Pro Ser Pro Pro Ala His Glu Ala Gly Tyr Ser Thr Leu Ala 
 625                630                635                640
Gln Ser Tyr Thr Ser Asp His Pro Ser Glu Leu Pro Glu Glu Pro Ser 
                 645                650                655
Ser Pro Gln Glu Arg Met Phe Thr Ile Asp Pro Lys Val Tyr Gly Glu 
             660                665                670
Lys Arg Asp Leu His Ser Lys Asn Lys Asp Asp Leu Thr Leu Ser Arg 
         675                680                685
Ser Leu Gly Leu Gly Gly Arg Ser Ala Ile Glu Gln Arg Ser Met Ser 
     690                695                700
Ile Asn Leu Pro Met Ser Cys Leu Asp Ser Ile Ala Leu Gly Phe Asn 
 705                710                715                720
Phe Gly Arg Gly His Asp Leu Ser Pro Leu Ala Ser Asp Ile Leu Thr 
                 725                730                735
Asn Thr Ser Gly Ser Met Asp Glu Gly Asp Asp Tyr Leu Pro Pro Thr 
             740                745                750
Thr Pro Ala Val Glu Lys Ile Pro Cys Phe Pro Ile Glu Ser Lys Glu 
         755                760                765
Glu Glu Asp Lys Thr Glu Gln Ala Lys Val Thr Gly Gly Gln Thr Thr 
     770                775                780
Gln Val Glu Thr Ser Ser Glu Ser Pro Phe Pro Ala Lys Glu Tyr Tyr 
 785                790                795                800
Lys Asn Gly Thr Val Met Ala Pro Asp Leu Pro Glu Met Leu Asp Leu 
                 805                810                815
Ala Gly Thr Arg Ser Arg Leu Ala Ser Val Ser Ala Asp Ala Glu Val 
             820                825                830
Ala Arg Arg Lys Ser Val Pro Ser Glu Ala Val Val Ala Glu Ser Ser 
         835                840                845
Thr Gly Leu Pro Pro Val Ala Asp Asp Ser Gln Pro Val Lys Pro Asp 
     850                855                860
Ser Gln Leu Glu Asp Met Gly Tyr Cys Val Phe Asn Lys Tyr Thr Val 
 865                870                875                880
Pro Leu Pro Ser Pro Val Gln Asp Ser Glu Asn Leu Ser Gly Glu Ser 
                 885                890                895
Gly Ser Phe Tyr Glu Gly Thr Asp Asp Lys Val Arg Arg Asp Leu Ala 
             900                905                910
Thr Asp Leu Ser Leu Ile Glu Val Lys Leu Ala Ala Ala Gly Arg Val 
         915                920                925
Lys Asp Glu Phe Thr Ala Glu Lys Glu Ala Ser Pro Pro Ser Ser Ala 
     930                935                940
Asp Lys Ser Gly Leu Ser Arg Glu Phe Asp Gln Asp Arg Lys Ala Asn 
 945                950                955                960
Asp Lys Leu Asp Thr Val Leu Glu Lys Ser Glu Glu His Val Asp Ser 
                 965                970                975
Lys Glu His Ala Lys Glu Ser Glu Glu Val Gly Asp Lys Val Glu Leu 
             980                985                990
Phe Gly Leu Gly Val Thr Tyr Glu Gln Thr Ser Ala Lys Glu Leu Ile 
         995                1000                1005
Thr Thr Lys Glu Thr Ala Pro Glu Arg Ala Glu Lys Gly Leu Ser Ser 
     1010                1015                1020
Val Pro Glu Val Ala Glu Val Glu Thr Thr Thr Lys Ala Asp Gln Gly 
 1025                1030                1035                1040
Leu Asp Val Ala Ala Lys Lys Asp Asp Gln Ser Pro Leu Asp Ile Lys 
                 1045                1050                1055
Val Ser Asp Phe Gly Gln Met Ala Ser Gly Met Ser Val Asp Ala Gly 
             1060                1065                1070
Lys Thr Ile Glu Leu Lys Phe Glu Val Asp Gln Gln Leu Thr Leu Ser 
         1075                1080                1085
Ser Glu Ala Pro Gln Glu Thr Asp Ser Phe Met Gly Ile Glu Ser Ser 
     1090                1095                1100
His Val Lys Asp Gly Ala Lys Val Ser Glu Thr Glu Val Lys Glu Lys 
 1105                1110                1115                1120
Val Ala Lys Pro Asp Leu Val His Gln Glu Ala Val Asp Lys Glu Glu 
                 1125                1130                1135
Ser Tyr Glu Ser Ser Gly Glu His Glu Ser Leu Thr Met Glu Ser Leu 
             1140                1145                1150
Lys Pro Asp Glu Gly Lys Lys Glu Thr Ser Pro Glu Thr Ser Leu Ile 
         1155                1160                1165
Gln Asp Glu Val Ala Leu Lys Leu Ser Val Glu Ile Pro Cys Pro Pro 
     1170                1175                1180
Pro Val Ser Glu Ala Asp Ser Ser Ile Asp Glu Lys Ala Glu Val Gln 
 1185                1190                1195                1200
Met Glu Phe Ile Gln Leu Pro Lys Glu Glu Ser Thr Glu Thr Pro Asp 
                 1205                1210                1215
Ile Pro Ala Ile Pro Ser Asp Val Thr Gln Pro Gln Pro Glu Ala Val 
             1220                1225                1230
Val Ser Glu Pro Ala Glu Val Arg Gly Glu Glu Glu Glu Ile Glu Ala 
         1235                1240                1245
Glu Gly Glu Tyr Asp Lys Leu Leu Phe Arg Ser Asp Thr Leu Gln Ile 
     1250                1255                1260
Thr Asp Leu Leu Val Pro Gly Ser Arg Glu Glu Phe Val Glu Thr Cys 
 1265                1270                1275                1280
Pro Gly Glu His Lys Gly Val Val Glu Ser Val Val Thr Ile Glu Asp 
                 1285                1290                1295
Asp Phe Ile Thr Val Val Gln Thr Thr Thr Asp Glu Gly Glu Leu Gly 
             1300                1305                1310
Ser His Ser Val Arg Phe Ala Ala Pro Val Gln Pro Glu Glu Glu Arg 
         1315                1320                1325
Arg Pro Tyr Pro His Asp Glu Glu Leu Glu Val Leu Met Ala Ala Glu 
     1330                1335                1340
Ala Gln Ala Glu Pro Lys Asp Gly Ser Pro Asp Ala Pro Ala Thr Pro 
 1345                1350                1355                1360
Glu Lys Glu Glu Val Pro Phe Ser Glu Tyr Lys Thr Glu Thr Tyr Asp 
                 1365                1370                1375
Asp Tyr Lys Asp Glu Thr Thr Ile Asp Asp Ser Ile Met Asp Ala Asp 
             1380                1385                1390
Ser Leu Trp Val Asp Thr Gln Asp Asp Asp Arg Ser Ile Leu Thr Glu 
         1395                1400                1405
Gln Leu Glu Thr Ile Pro Lys Glu Glu Arg Ala Glu Lys Glu Ala Arg 
     1410                1415                1420
Arg Pro Ser Leu Glu Lys His Arg Lys Glu Lys Pro Phe Lys Thr Gly 
 1425                1430                1435                1440
Arg Gly Arg Ile Ser Thr Pro Glu Arg Arg Glu Val Ala Lys Lys Glu 
                 1445                1450                1455
Pro Ser Thr Val Ser Arg Asp Glu Val Arg Arg Lys Lys Ala Val Tyr 
             1460                1465                1470
Lys Lys Ala Glu Leu Ala Lys Glu Ser Glu Val Gln Ala His Ser Pro 
         1475                1480                1485
Ser Arg Lys Leu Ile Leu Lys Pro Ala Ile Lys Tyr Thr Arg Pro Thr 
     1490                1495                1500
His Leu Ser Cys Val Lys Arg Lys Thr Thr Ala Thr Ser Gly Glu Ser 
 1505                1510                1515                1520
Ala Gln Ala Pro Ser Ala Phe Lys Gln Ala Lys Asp Lys Val Thr Asp 
                 1525                1530                1535
Gly Ile Thr Lys Ser Pro Glu Lys Arg Ser Ser Leu Pro Arg Pro Ser 
             1540                1545                1550
Ser Ile Leu Pro Pro Arg Arg Gly Val Ser Gly Asp Arg Glu Glu Asn 
         1555                1560                1565
Ser Phe Ser Leu Asn Ser Ser Ile Ser Ser Ala Arg Arg Thr Thr Arg 
     1570                1575                1580
Ser Glu Pro Ile Arg Arg Ala Gly Lys Ser Gly Thr Ser Thr Pro Thr 
 1585                1590                1595                1600
Thr Pro Gly Ser Thr Ala Ile Thr Pro Gly Thr Pro Pro Ser Tyr Ser 
                 1605                1610                1615
Ser Arg Thr Pro Gly Thr Pro Gly Thr Pro Ser Tyr Pro Arg Thr Pro 
             1620                1625                1630
Gly Thr Pro Lys Ser Gly Ile Leu Val Pro Ser Glu Lys Lys Val Ala 
         1635                1640                1645
Ile Ile Arg Thr Pro Pro Lys Ser Pro Ala Thr Pro Lys Gln Leu Arg 
     1650                1655                1660
Leu Ile Asn Gln Pro Leu Pro Asp Leu Lys Asn Val Lys Ser Lys Ile 
 1665                1670                1675                1680
Gly Ser Thr Asp Asn Ile Lys Tyr Gln Pro Lys Gly Gly Gln Val Arg 
                 1685                1690                1695
Ile Leu Asn Lys Lys Met Asp Phe Ser Lys Val Gln Ser Arg Cys Gly 
             1700                1705                1710
Ser Lys Asp Asn Ile Lys His Ser Ala Gly Gly Gly Asn Val Gln Ile 
         1715                1720                1725
Val Thr Lys Lys Ile Asp Leu Ser His Val Thr Ser Lys Cys Gly Ser 
     1730                1735                1740
Leu Lys Asn Ile Arg His Arg Pro Gly Gly Gly Arg Val Lys Ile Glu 
 1745                1750                1755                1760
Ser Val Lys Leu Asp Phe Lys Glu Lys Ala Gln Ala Lys Val Gly Ser 
                 1765                1770                1775
Leu Asp Asn Ala His His Val Pro Gly Gly Gly Asn Val Lys Ile Asp 
             1780                1785                1790
Ser Gln Lys Leu Asn Phe Arg Glu His Ala Lys Ala Arg Val Asp His 
         1795                1800                1805
Gly Ala Glu Ile Ile Thr Gln Ser Pro Ser Arg Ser Ser Val Ala Ser 
     1810                1815                1820
Pro Arg Arg Leu Ser Asn Val Ser Ser Ser Gly Ser Ile Asn Leu Leu 
 1825                1830                1835                1840
Glu Ser Pro Gln Leu Ala Thr Leu Ala Glu Asp Val Thr Ala Ala Leu 
                 1845                1850                1855
Ala Lys Gln Gly Leu 
             1860



<210> 8330
<211> 2124
<212> DNA
<213> Homo sapiens
<308> AK056148
<400> 8330

cattcatct  agacttaca  ataaggaat  aaatagtca  tggcctgat  aaggcaaag  60
gctaccagg  tagatggac  ctttttaaa  attttatct  ttctttttc  tgctcaggg  120
tggtaggtt  gatctgaac  attaaaatc  aatggtcca  taggcgtat  atctctttg  180
gccaaatca  ttcctgaat  taaaggagg  aatgatgag  atgtactga  gcaacgggg  240
agtatagaa  catccaaga  aaaagccaa  ggatgcaaa  gcagagaca  aggtgcttt  300
tggtgaccc  gtggatatg  caaccagtg  aactgccat  caagaaacc  taggagcaa  360
cccacacca  tcattctca  ctaagagat  ttacacagg  aaacgtgtc  taaaccatc  420
ataaatcag  tattttata  gacagtcaa  accttagaa  ccttaggat  attatatct  480
ttttctgcc  attaattgc  gtgaggttt  atttgacca  tctgggcaa  ttattcatc  540
gcttccctt  aagtgcacc  gaaaataga  gaaaggtgt  tggagactt  gggtatttt  600
ttacatgtt  tcatagtct  aaatagtga  taaatttct  tagaaagaa  ttaacagct  660
attagaaaa  ttttaacct  tgaaataag  atttttctc  acattcttt  aagttttta  720
ataagttaa  actaggtaa  cattctgca  actagaagt  agtttatta  aaatacatg  780
caaaaataa  gattataca  ggcaccaaa  tactagatt  ggcattaaa  caaatgttt  840
tttctaatc  caacaaaat  ataatgaat  aatgttctt  ctttgtatg  aaatacaat  900
ctttattaa  gttaacaga  aggaactga  cgtttgtac  agtaaaaga  agaaacaca  960
aggttaaat  tcttcttgt  gggttaagg  gtagaacct  tcttgcctt  actctcaag  1020
taacgactc  aattaagct  tttgagcac  actcttgtg  ggacacaca  acgctgatc  1080
aggaatgaa  tcttcgtgg  ctcaattct  gatctacta  gccagtttc  ctctggctt  1140
agcctttga  aacctgtat  agaatacgt  agtaatcca  agctgtgaa  agtttaaag  1200
ccaacttct  cagtgaact  aacctctgg  tcacttgca  ccagaaatt  gatacctca  1260
aatgatgca  gaaagaccc  agttcatga  gagtttcaa  ggccacgtt  atttaggaa  1320
caactctct  tggatttac  tgctgagtt  cagcagcgt  atgggctga  atcccacct  1380
caagtatga  acctgtgta  caccagcta  gtacggctg  agaaggctg  agagagaat  1440
ccattaaat  gaagaatgt  ctgattgta  tgaccttct  cacacacac  cacacacac  1500
cacacacct  cagtaatac  gcaagcgtg  aataatcag  caatatata  cattccatc  1560
gtattttat  aaggaaata  cctgaatgt  gttgatttt  acatagctg  aattacagt  1620
ttcttctat  tttcaagcc  caataagga  aataaacta  tcatggtct  aatactaga  1680
ataaagtag  ttcatggct  ggtaaggaa  ttttaagca  tccttcaaa  attgacgtg  1740
taaaataag  attgatgtt  tgagttttt  tacacctag  atttttagc  tgggtgtgt  1800
ggtgaaggc  aagactctc  gcaggaaaa  gcttatttt  aaactcaga  aataaaatg  1860
caatcataa  aatctactt  aactttagc  aaaagaaaa  aaaatcaac  aaaagtata  1920
tctgtatgc  gggattccg  ggttccaac  cactgttac  aatctgtgg  gggtttctt  1980
cttctgata  ttctagagc  tgttaccat  gaaaggcat  tcttcaatg  ctggttgta  2040
ttagttcat  tttttcaat  aaatttgca  atgtatttg  tgctgtata  tgattgttt  2100
gcaaaataa  attgcttgt  acct  2124



<210> 8331
<211> 997
<212> DNA
<213> Rattus norvegicus
<308> U31203
<400> 8331

ggagggggc  ggggaccgg  tggaggtgc  gaggacctg  cggagctgg  ccagctgct  60
cggcagcgg  cgtcggggg  catgccgag  gagatcaaa  ggctggagt  ctccgaggg  120
ttggcccaa  gcaagaagc  gcgcctgag  aagaagctg  ggaggaagt  acagatgtg  180
ctgtggtca  agaccttct  cccggtgct  tacgcgtgg  acgacctag  cagccgttt  240
tgggcgcgc  acgtgaagg  gggcagctg  ttcagcaag  gctcctgct  tgtgcctga  300
ggcatggtg  gtaagccat  caagtctgt  cacctcacc  tgctgcggt  gcgctgtca  360
cggcgcggg  gtcagcgct  cggctggat  cccatccag  accccatca  ttccgagtg  420
aagtgttcc  gctagaact  ggggncccc  gcccgcgcc  agacacttg  tggatcccc  480
ccaacgccc  ccaccccca  cgnctccaa  cagttccac  accctctag  gagggtttt  540
aatgaactt  ttttttctt  ttggataca  agacctggc  ttctggttc  tgtaatgca  600
tgtttaact  tgtaggaat  tatatgtgt  tatatacgg  cccagtttt  atttactta  660
taaaaggtc  gtattatac  tcaaaagtt  cccggcttc  actgtattt  aaaaaaata  720
gcaagcaaa  tgaaaaaaa  aaagagcag  gaaaagaga  actnattct  gntgttggt  780
ataatgtta  cctgctatt  atatcccaa  gcccttcgc  tggngaagc  ggggggaaa  840
gttattttt  tcttaaaag  acaaagaga  ggggaactt  ggtagaagg  cttttaaaa  900
agctatttn  catcctccg  aaatgtntg  tttcctagn  ncgagagta  gagtcatgt  960
tttncagta  gtatttgag  caatggatg  tatcatg  997



<210> 8332
<211> 144
<212> PRT
<213> Rattus norvegicus
<308> Q62809
<400> 8332

Gly Gly Gly Gly Gly Pro Ala Gly Gly Ala Glu Asp Leu Ala Glu Leu 
  1               5                  10                  15
Asp Gln Leu Leu Arg Gln Arg Pro Ser Gly Ala Met Pro Ser Glu Ile 
             20                  25                  30
Lys Gly Leu Glu Phe Ser Glu Gly Leu Ala Gln Gly Lys Lys Gln Arg 
         35                  40                  45
Leu Ser Lys Lys Leu Arg Arg Lys Leu Gln Met Trp Leu Trp Ser Gln 
     50                  55                  60
Thr Phe Cys Pro Val Leu Tyr Ala Trp Asn Asp Leu Gly Ser Arg Phe 
 65                  70                  75                  80
Trp Ala Arg Tyr Val Lys Val Gly Ser Cys Phe Ser Lys Arg Ser Cys 
                 85                  90                  95
Ser Val Pro Glu Gly Met Val Cys Lys Pro Ser Lys Ser Val His Leu 
             100                105                110
Thr Val Leu Arg Trp Arg Cys Gln Arg Arg Gly Gly Gln Arg Cys Gly 
         115                120                125
Trp Ile Pro Ile Gln Tyr Pro Ile Ile Ser Glu Cys Lys Cys Ser Cys 
     130                135                140



<210> 8333
<211> 699
<212> DNA
<213> Homo sapiens
<308> NM_005450
<400> 8333

atggagcgc  gccccagcc  aggggtcac  ctctacgcc  tggtggtgg  cctggggct  60
cgggcgaca  cggccggcg  ccagcacta  ctccacatc  gcccggcac  cagcgacaa  120
ctgcccctg  tggacctca  cgaacaccc  gaccctatc  ttgacccca  ggaaaagga  180
ctgaacgag  cgctgctgc  ctcgctgct  gggggccac  acgacccag  cttcatggc  240
acctcgccc  ccgaggacc  gcccggcgg  ggcgggggt  cagctgggg  cgcggagga  300
ctggcggag  tggaccagc  gctgcggca  cggccgtcg  gggccatgc  gagcgagat  360
aaagggcta  agttctccg  gggcttggc  cagggcaag  agcagcgcc  aagcaagaa  420
ctgcggagg  agttacaga  gtggctgtg  tcgcagaca  tctgccccg  gctgtacgc  480
tggaacgac  tgggcagcc  cttttggcc  cgctacgtg  aggtgggca  ctgcttcag  540
aagcgctcg  gctccgtgc  cgagggcat  gtgtgcaag  cgtccaagt  cgtgcacct  600
acggtgctg  ggtggcgct  tcagcggcg  gggggccag  gctgcggct  gattcccat  660
cagtacccc  tcatttccg  gtgcaagtg  tcgtgctag  699



<210> 8334
<211> 232
<212> PRT
<213> Homo sapiens
<308> NP_005441
<400> 8334

Met Glu Arg Cys Pro Ser Leu Gly Val Thr Leu Tyr Ala Leu Val Val 
  1               5                  10                  15
Val Leu Gly Leu Arg Ala Thr Pro Ala Gly Gly Gln His Tyr Leu His 
             20                  25                  30
Ile Arg Pro Ala Pro Ser Asp Asn Leu Pro Leu Val Asp Leu Ile Glu 
         35                  40                  45
His Pro Asp Pro Ile Phe Asp Pro Lys Glu Lys Asp Leu Asn Glu Thr 
     50                  55                  60
Leu Leu Arg Ser Leu Leu Gly Gly His Tyr Asp Pro Gly Phe Met Ala 
 65                  70                  75                  80
Thr Ser Pro Pro Glu Asp Arg Pro Gly Gly Gly Gly Gly Ala Ala Gly 
                 85                  90                  95
Gly Ala Glu Asp Leu Ala Glu Leu Asp Gln Leu Leu Arg Gln Arg Pro 
             100                105                110
Ser Gly Ala Met Pro Ser Glu Ile Lys Gly Leu Glu Phe Ser Glu Gly 
         115                120                125
Leu Ala Gln Gly Lys Lys Gln Arg Leu Ser Lys Lys Leu Arg Arg Lys 
     130                135                140
Leu Gln Met Trp Leu Trp Ser Gln Thr Phe Cys Pro Val Leu Tyr Ala 
 145                150                155                160
Trp Asn Asp Leu Gly Ser Arg Phe Trp Pro Arg Tyr Val Lys Val Gly 
                 165                170                175
Ser Cys Phe Ser Lys Arg Ser Cys Ser Val Pro Glu Gly Met Val Cys 
             180                185                190
Lys Pro Ser Lys Ser Val His Leu Thr Val Leu Arg Trp Arg Cys Gln 
         195                200                205
Arg Arg Gly Gly Gln Arg Cys Gly Trp Ile Pro Ile Gln Tyr Pro Ile 
     210                215                220
Ile Ser Glu Cys Lys Cys Ser Cys 
 225                230



<210> 8335
<211> 1496
<212> DNA
<213> Rattus norvegicus
<308> U31668
<400> 8335

gcgggggca  cagcaggca  gagaagagc  tggggttgc  caccaccaa  ttcgtgtcg  60
tgctgcagg  ggcgcagga  ggcgtcctg  atctcaaag  ggctgcaga  actttggct  120
tgaggcaaa  gcgaagaat  tatgatatc  ccaacgtct  agaaggaat  gatctaatt  180
aaaaaaaat  aaagaacag  atccagtgg  agggtgtag  tgctggctg  aatactaaa  240
aagttatag  tagattaag  tgtcttaaa  ctgaaattg  agatctaga  ttgaaggaa  300
gagaacttg  ccagcagaa  ttgtggcta  agcaaagca  caaaaacgt  atggaagac  360
ccattaata  cagattttc  tatgtaact  acgaagaca  ctgcagttg  tttaatggt  420
atacactgt  ggccattca  gcaccctct  gtacacagc  ggaagtacc  attccagaa  480
tgggacaga  tggacaaaa  aaataccag  taaatctga  gagtcactc  ggaccaatc  540
atgtgctac  tataaataa  gagtccaac  catctaagc  ggtggtttt  cctgtcccc  600
cacctgatg  cctcacaca  ccttcctcc  agtcctcaa  ttcagtgac  ccaccgaaa  660
ccaccatgg  tgctcaaaa  ctgcccgag  agcatgttt  tgaaagaag  cagaatttc  720
agcagacac  agctacaga  atatcttca  gatctatta  tggagacat  attgatgaa  780
tgatgtctt  tgacgtgtt  cctctctta  ggctgtctc  taccccagc  gatgactac  840
actttaatt  agatgataa  gaaggagtt  gtgatctgt  tgatgttca  atactaaat  900
attagattc  acggaaact  gggactgtt  tctacctct  actgtaaca  tttagaatt  960
ttaataacc  aagtattta  aattatgaa  gtaacacct  tttagttca  tgactctaa  1020
gtgttttcc  aacatttta  ttttacttc  caaaacttg  aagggctct  actgcttca  1080
ggggggata  ttaactgtc  accagcatg  ccctccagt  attacactc  gtttcattc  1140
gtgctgaat  ctgtagctt  ttcttagag  acagttaca  caggcttca  ttcatcata  1200
caaaacatt  tccaaaaga  cacttactt  tcttatgtt  ttactgcca  agctgtttc  1260
atgtatcct  caaacagac  ttcactgcc  tatataaag  gaaggatat  actgttgag  1320
gaacagatt  tgtgaagtg  cttctgttt  agcacttta  gtctatcag  ttgttgatt  1380
agacactcc  ctttcctag  gtataggaa  gatctgttt  tgtagtttg  ttttaaaat  1440
tgccaatgc  tgtacatta  caagattta  agaaataaa  ttgtatgaa  cattga  1496



<210> 8336
<211> 300
<212> PRT
<213> Rattus norvegicus
<308> Q62814
<400> 8336

Gly Gly Ser Ser Arg His Glu Lys Ser Leu Gly Leu Leu Thr Thr Lys 
  1               5                  10                  15
Phe Val Ser Leu Leu Gln Glu Ala Gln Asp Gly Val Leu Asp Leu Lys 
             20                  25                  30
Ala Ala Ala Asp Thr Leu Ala Val Arg Gln Lys Arg Arg Ile Tyr Asp 
         35                  40                  45
Ile Thr Asn Val Leu Glu Gly Ile Asp Leu Ile Glu Lys Lys Ser Lys 
     50                  55                  60
Asn Ser Ile Gln Trp Lys Gly Val Gly Ala Gly Cys Asn Thr Lys Glu 
 65                  70                  75                  80
Val Ile Asp Arg Leu Arg Cys Leu Lys Ala Glu Ile Glu Asp Leu Glu 
                 85                  90                  95
Leu Lys Glu Arg Glu Leu Asp Gln Gln Lys Leu Trp Leu Gln Gln Ser 
             100                105                110
Ile Lys Asn Val Met Glu Asp Ser Ile Asn Asn Arg Phe Ser Tyr Val 
         115                120                125
Thr His Glu Asp Ile Cys Ser Cys Phe Asn Gly Asp Thr Leu Leu Ala 
     130                135                140
Ile Gln Ala Pro Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met 
 145                150                155                160
Gly Gln Asn Gly Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser 
                 165                170                175
Gly Pro Ile His Val Leu Leu Ile Asn Lys Glu Ser Asn Ser Ser Lys 
             180                185                190
Pro Val Val Phe Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser 
         195                200                205
Ser Gln Ser Ser Thr Ser Val Thr Pro Pro Lys Ser Thr Met Ala Ala 
     210                215                220
Gln Asn Leu Pro Glu Gln His Val Ser Glu Arg Ser Gln Asn Phe Gln 
 225                230                235                240
Gln Thr Pro Ala Thr Glu Ile Ser Ser Gly Ser Ile Ser Gly Asp Ile 
                 245                250                255
Ile Asp Glu Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu Ser 
             260                265                270
Pro Thr Pro Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly 
         275                280                285
Val Cys Asp Leu Phe Asp Val Gln Ile Leu Asn Tyr 
     290                295                300



<210> 8337
<211> 1697
<212> DNA
<213> Homo sapiens
<308> Z78409
<400> 8337

cgggggggc  cgaccaccg  ggggccggg  cgcgatggc  gcggcagag  ccgcgagct  60
gggccagca  gcgccggca  ggcaggggc  gggccagcg  ccgccgccg  agcctccgc  120
ggcgcaagc  ccgcagccg  ccccgccgc  gcagctcgg  ggcgcgggg  gcggcagca  180
caggcacga  aagagcctg  ggctgctca  taccaagtt  gtgtcgctg  tgcaggagg  240
caaggacgg  gttctggat  tcaaagcgg  tgctgatac  ttggctgtg  ggcaaaaaa  300
gagaattta  gatatcacc  atgtcttag  gggaattga  ttgattgaa  aaaagtcaa  360
aaacagtat  cagtggaaa  gtgtaggtg  tggctgtaa  actaaagaa  tcatagata  420
attaagata  cttaaagct  aaattgaag  tctagaact  aaggaaaga  aacttgatc  480
gcagaagtt  ttgctacag  aaagcatca  aaatgtgat  gacgattcc  ttaataata  540
attttccta  gtaactcat  aagacatct  taattgctt  aatggtgat  cacttttgg  600
cattcaggc  ccttctggt  cacaactgg  ggtacccat  ccagaaatg  gtcagaatg  660
acaaaagaa  taccagatc  atctaaaga  tcattcagg  cctatccat  tgctgctta  720
aaataaaga  tcgagttca  ctaagcccg  ggtttttcc  gttccccca  ctgatgacc  780
cacacagcc  tcctcccag  ccttgactc  agtgactcc  cagaaatcc  gcatggcaa  840
tcaaaatct  cctgagcaa  atgtctctg  aagaagcca  gctctgcag  agacatcag  900
tacagatat  tcttcagca  gatctatta  tggagatat  attgatgag  taatgtctt  960
tgacgtgtt  cctctctta  ggctttctc  taccccggc  gatgactac  actttaatt  1020
agatgataa  gaaggagtt  gtgatctgt  tgatgtcca  atactaaat  attagattc  1080
atggaaact  gggactgtt  tctacctct  actgtgtaa  attttagac  tcttaataa  1140
ctaaatatt  aaaataatg  atgtaacac  ttttttagt  cactgattc  gaagtgttc  1200
tccctaata  tttctttac  tcacaaaac  tcaaccata  aaacaaagg  ctctgattg  1260
tttagggga  aagtgattt  atattcaca  acgtcccca  tcccaaaag  aactatatt  1320
tggatttca  cttttcttc  aattgtgaa  ccttccgtt  tttcttctt  aggaggaaa  1380
ttaaaggac  ctacaggtc  tcaaaaaca  gttggccaa  gactcatta  ttgtcttat  1440
tttttactg  cactaaact  cctgtattt  tgtatgtcc  tctatccaa  cagacgttc  1500
ctgccactt  taaagtgaa  gatgtaaac  aggatatat  actgtttca  tgaacagat  1560
ttgtgaagt  ccttctgtt  tagcacttt  agtttatca  attttgttg  cttctgaca  1620
tccactttc  taggttata  gaaagatct  tttatgtag  ttgttttta  aatgtgcca  1680
tgcctgtac  ttaacaa  1697



<210> 8338
<211> 346
<212> PRT
<213> Homo sapiens
<308> Q15329
<400> 8338

Met Ala Ala Ala Glu Pro Ala Ser Ser Gly Gln Gln Ala Pro Ala Gly 
  1               5                  10                  15
Gln Gly Gln Gly Gln Arg Pro Pro Pro Gln Pro Pro Gln Ala Gln Ala 
             20                  25                  30
Pro Gln Pro Pro Pro Pro Pro Gln Leu Gly Gly Ala Gly Gly Gly Ser 
         35                  40                  45
Ser Arg His Glu Lys Ser Leu Gly Leu Leu Thr Thr Lys Phe Val Ser 
     50                  55                  60
Leu Leu Gln Glu Ala Lys Asp Gly Val Leu Asp Leu Lys Ala Ala Ala 
 65                  70                  75                  80
Asp Thr Leu Ala Val Arg Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn 
                 85                  90                  95
Val Leu Glu Gly Ile Asp Leu Ile Glu Lys Lys Ser Lys Asn Ser Ile 
             100                105                110
Gln Trp Lys Gly Val Gly Ala Gly Cys Asn Thr Lys Glu Val Ile Asp 
         115                120                125
Arg Leu Arg Tyr Leu Lys Ala Glu Ile Glu Asp Leu Glu Leu Lys Glu 
     130                135                140
Arg Glu Leu Asp Gln Gln Lys Leu Trp Leu Gln Gln Ser Ile Lys Asn 
 145                150                155                160
Val Met Asp Asp Ser Ile Asn Asn Arg Phe Ser Tyr Val Thr His Glu 
                 165                170                175
Asp Ile Cys Asn Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln Ala 
             180                185                190
Pro Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln Asn 
         195                200                205
Gly Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro Ile 
     210                215                220
His Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val 
 225                230                235                240
Phe Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser 
                 245                250                255
Leu Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu 
             260                265                270
Pro Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser 
         275                280                285
Ala Thr Asp Ile Ser Ser Ala Gly Ser Ile Ser Gly Asp Ile Ile Asp 
     290                295                300
Glu Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro Thr 
 305                310                315                320
Pro Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val Cys 
                 325                330                335
Asp Leu Phe Asp Val Gln Ile Leu Asn Tyr 
             340                345



<210> 8339
<211> 2657
<212> DNA
<213> Rattus norvegicus
<308> U31866
<400> 8339

gtttttttt  ttttttttt  ttttttttt  tttttttat  aagaataag  gatccgttt  60
ggatttatt  catttaaag  cggcagatt  ttaaaacag  aggtatgat  aatacagta  120
gaaaataac  ttaaatctc  aacaaaaca  tgaacagaa  tcaagacta  gcaatgtaa  180
ggcaataag  taacaaaat  agtgcttta  tgggtacag  gaaagtaac  gaagtctat  240
tcaaactct  cccggctac  tttgagggc  taagttact  tagcaagta  gtctttata  300
caattagaa  tataactaa  gatataaac  cagtttatt  aaaaattaa  gttatttgc  360
tagtggtac  taaaaggct  cagaaaatt  aagtttaac  aaaaaaaaa  aaaaaggaa  420
tgtaatcaa  gaaagtgca  ttaaagccg  ttgccagca  ttaaagggc  cttccaggc  480
ggaggtgtg  ctcagccct  aagcgcttg  ccagcatgt  caaggccct  ggttcagtt  540
ccagcaccg  aaaagaaag  acaagtggc  attactcct  ctagtatag  atgatctct  600
agtcacaaa  gaacatagt  ataaaatca  tcttcctgt  ggcactgtg  acctttaat  660
aaaaaaaaa  aacctaaac  agacccagc  ctctgaatt  tcatctact  cttcctttt  720
gtggctttt  taaacttcg  aactaggag  gaatgctct  aagagaaac  attgccttt  780
taaattcac  ttaattccg  agtggagag  ctcgatgtg  ctgtgtctt  ttatcttag  840
agagaacac  accgagtgt  aatttttcc  acagtcatc  gttgttctc  cagtagact  900
agtagactg  caactcagt  actgaatgt  aattgatga  tagttttgc  tagaaataa  960
agaaaaaga  tgacagagt  cactgcgca  tctacatgt  ttaaacaga  aatacctaa  1020
tccccacag  tagtgacat  aatacatgt  cgccttctg  cagtgcttt  gtgaagtgc  1080
caaatctgg  taacccaag  gaggcacac  caagactgg  tccaccttc  tattttccg  1140
cagaagagg  gagtagtca  tccctgtta  acagggtag  actgatcgc  aggtgcgca  1200
atccgagag  cacgtgact  cataaatgc  cagggtaca  agctcaggg  aggggcact  1260
agtttaaat  tggtcggtt  cattctcac  caacttgga  tagtccttt  tccaactac  1320
taccgagaa  gtctgtgcc  tagtagata  ctttcttaa  tgccctgaa  gatcctctg  1380
taatactag  gttttgctg  cgtgatcaa  gtaaagcaa  tagtccact  tttaagaaa  1440
gattccaag  taatgagca  agttaaagc  tctaggtga  acctttggc  tcagacttt  1500
gagctgggt  cctaacgtg  cttcccttc  atgttcaag  ctaacaggt  tagttagaa  1560
tgctttgca  actgggaag  acaaggcac  cccaaatga  attctttaa  ccagaactg  1620
gccgtccca  aacagagcc  gcctttcag  gagtgctgg  tgctgggtg  tgggtgctg  1680
gtgctaagt  ctctcttga  caagagaaa  gtaacgcaa  ggagccgcc  cttggacct  1740
cagtgaaac  gtctgtcca  tgagatgat  tcgagaggc  cgtcaccgc  gggctgttg  1800
aggcaatgt  aacatttta  gctgtggca  agctgtttc  taaggattt  tccagcatt  1860
gccggaggg  ctgcgagtg  tcacttcta  gtattcagt  cagtgaaag  cgagtggaa  1920
tctgacttc  tagtcacaa  tcattactt  aggaggaaa  catttctgt  cggtagcgt  1980
gagggccta  tgccatttg  attagtgag  ataatcaac  tgagaacca  acagaaagg  2040
gcaaacaca  ctctccttt  gcacaagga  attaagtgg  gaaggcatc  gactccagc  2100
tcaactgga  caacctgaa  ggcaagaag  cctgccata  tggagtaga  agaaccgcc  2160
gctggaaca  ccctatggg  ctgctgttc  gcaggatca  ccactgcaa  ttcggtgag  2220
agagccggg  agggagatt  ggaggggcc  tgcagaaaa  aaggggccc  aagaagggc  2280
ataggtttg  ggtccataa  agtgaagcc  ctcaaaaat  aacctcaag  aaataggga  2340
gaggactag  aggaaccag  ggctaagga  tggagtcag  acggttgtc  ttattgcaa  2400
taatggcat  agtggctat  cattcgctt  tctctctca  gatggagat  agaggtgag  2460
attctgtgg  tgataaggt  ttgagggct  cttccttct  tctggacca  catttccat  2520
atagtactt  cacattcaa  aagcaacct  gctgaggca  tcacaattc  ggcaagaac  2580
agagcaagt  gaaatgtac  ccaaccgtg  tcagtgttt  aaaagagcc  tctgctggg  2640
tcggtcccc  gctctga  2657



<210> 8340
<211> 2036
<212> DNA
<213> Homo sapiens
<308> AK021725
<400> 8340

acattctta  aacacagca  agtgacttt  ttctttcaa  attgtagct  agagaaaag  60
tacaggatt  aattggggg  tcaatagga  agaaatgga  agattcctt  gtgttgtag  120
agaggcatt  tcctaagga  tatagattt  tactttgca  tttcattca  catccccca  180
aatcatggt  aaggtgtag  tcactccac  cagctgatg  tcaggttat  cccttgtga  240
aattatgag  ataaagctc  caagatatg  gaaagtgct  aacacagta  ctggcacac  300
gcactcaat  aaagtttgg  tctattatg  gatggttca  ttctggttt  aggagggaa  360
aaaggttat  atatatgta  cactaagca  atatatata  atatatata  atttgggtt  420
ttttttccc  aatattatt  gggtgtccc  tgtgcttct  taggatgta  ttataacta  480
acctgttat  cttgaacat  actaagaga  gtaaattat  atgaagcta  caaaaatct  540
gaggccaaa  ttgtttctt  acagcttta  taatgcttg  tgattttga  taatccttt  600
aaaagtgga  catttgctt  ttttaatat  acgtcagta  aatgttagt  ttaaaaaga  660
cagcttttt  tggcattga  gaatgtatc  gctaagaca  aaaaattgc  tggtaagta  720
aataggtgg  ggaggaaag  ttgtaggcc  gatgaaaat  taactgact  gaacattta  780
tcaggagtg  aattatttt  ccttacccc  atccctgtg  acgtgttgg  tatagttac  840
acattatcc  gatttgcaa  tagacacaa  tttcagtct  accctgttt  ttgtttaag  900
gtgatagac  gttgtcctc  tgctggtgg  aaatctaag  tggagccca  tcttctatg  960
tgaagttca  caggcagag  agttttctt  caagtcagc  actctgctt  gtttatttt  1020
ggttttggt  cttcacgta  gcactgtta  aaggtacaa  tgtattaat  tcactagtt  1080
tgaggcgct  gggtacatt  gtttttaat  tatttagaa  gtgcagtaa  cttttttct  1140
atttttttt  ctttttagc  aacttgtta  tttaggtcc  attattgag  tgacagtct  1200
ctgtgagaa  gagatgaca  atctactgt  agaatacca  aaatgatga  tagtttatt  1260
gagaacttt  atactcagt  gtgttttat  tattaagat  aaaatatgt  cacacatgc  1320
tgtcacatc  ctctactgt  gagttaatg  gaattttta  aaaatggaa  tgcaaccac  1380
accatatct  agagaacat  cactcctag  gagggttta  aaaagctac  aagagaata  1440
ggtagatga  aatgcaaag  gtcatgatt  ggggttatt  ttgttttat  ttaaaattt  1500
tactgctac  tttgaaaga  ttgttttta  gactatgct  tttttgtga  tgaaaagtc  1560
tctaataga  gctgtatag  agctacttt  taattgctg  caaacagct  taagtgcac  1620
ttctttgat  acacttcca  tttttgtta  acttgaatt  tctgaagcc  tttatgtac  1680
actaagcaa  taactttaa  ctttaaata  agcaaattt  catctttat  gtatttcta  1740
ttgttacaa  acatacttg  taaagtaac  tcagtcctc  aatatagct  ggaaacaat  1800
atgagatag  ctcagtctc  ccctcccac  ccttttccc  tgccatatc  aattaagca  1860
taactgatt  tattacttt  ttgccttta  actgcttat  ctttttgac  gaattctgt  1920
cctgattca  tgttttgtt  gaaatttaa  gttattttc  tactgtatt  atcatacct  1980
ttttaatct  ttttcttta  atgcaataa  tcccaaatg  attgcatat  ctttat  2036



<210> 8341
<211> 2657
<212> DNA
<213> Rattus norvegicus
<308> U31866
<400> 8341

gtttttttt  ttttttttt  ttttttttt  tttttttat  aagaataag  gatccgttt  60
ggatttatt  catttaaag  cggcagatt  ttaaaacag  aggtatgat  aatacagta  120
gaaaataac  ttaaatctc  aacaaaaca  tgaacagaa  tcaagacta  gcaatgtaa  180
ggcaataag  taacaaaat  agtgcttta  tgggtacag  gaaagtaac  gaagtctat  240
tcaaactct  cccggctac  tttgagggc  taagttact  tagcaagta  gtctttata  300
caattagaa  tataactaa  gatataaac  cagtttatt  aaaaattaa  gttatttgc  360
tagtggtac  taaaaggct  cagaaaatt  aagtttaac  aaaaaaaaa  aaaaaggaa  420
tgtaatcaa  gaaagtgca  ttaaagccg  ttgccagca  ttaaagggc  cttccaggc  480
ggaggtgtg  ctcagccct  aagcgcttg  ccagcatgt  caaggccct  ggttcagtt  540
ccagcaccg  aaaagaaag  acaagtggc  attactcct  ctagtatag  atgatctct  600
agtcacaaa  gaacatagt  ataaaatca  tcttcctgt  ggcactgtg  acctttaat  660
aaaaaaaaa  aacctaaac  agacccagc  ctctgaatt  tcatctact  cttcctttt  720
gtggctttt  taaacttcg  aactaggag  gaatgctct  aagagaaac  attgccttt  780
taaattcac  ttaattccg  agtggagag  ctcgatgtg  ctgtgtctt  ttatcttag  840
agagaacac  accgagtgt  aatttttcc  acagtcatc  gttgttctc  cagtagact  900
agtagactg  caactcagt  actgaatgt  aattgatga  tagttttgc  tagaaataa  960
agaaaaaga  tgacagagt  cactgcgca  tctacatgt  ttaaacaga  aatacctaa  1020
tccccacag  tagtgacat  aatacatgt  cgccttctg  cagtgcttt  gtgaagtgc  1080
caaatctgg  taacccaag  gaggcacac  caagactgg  tccaccttc  tattttccg  1140
cagaagagg  gagtagtca  tccctgtta  acagggtag  actgatcgc  aggtgcgca  1200
atccgagag  cacgtgact  cataaatgc  cagggtaca  agctcaggg  aggggcact  1260
agtttaaat  tggtcggtt  cattctcac  caacttgga  tagtccttt  tccaactac  1320
taccgagaa  gtctgtgcc  tagtagata  ctttcttaa  tgccctgaa  gatcctctg  1380
taatactag  gttttgctg  cgtgatcaa  gtaaagcaa  tagtccact  tttaagaaa  1440
gattccaag  taatgagca  agttaaagc  tctaggtga  acctttggc  tcagacttt  1500
gagctgggt  cctaacgtg  cttcccttc  atgttcaag  ctaacaggt  tagttagaa  1560
tgctttgca  actgggaag  acaaggcac  cccaaatga  attctttaa  ccagaactg  1620
gccgtccca  aacagagcc  gcctttcag  gagtgctgg  tgctgggtg  tgggtgctg  1680
gtgctaagt  ctctcttga  caagagaaa  gtaacgcaa  ggagccgcc  cttggacct  1740
cagtgaaac  gtctgtcca  tgagatgat  tcgagaggc  cgtcaccgc  gggctgttg  1800
aggcaatgt  aacatttta  gctgtggca  agctgtttc  taaggattt  tccagcatt  1860
gccggaggg  ctgcgagtg  tcacttcta  gtattcagt  cagtgaaag  cgagtggaa  1920
tctgacttc  tagtcacaa  tcattactt  aggaggaaa  catttctgt  cggtagcgt  1980
gagggccta  tgccatttg  attagtgag  ataatcaac  tgagaacca  acagaaagg  2040
gcaaacaca  ctctccttt  gcacaagga  attaagtgg  gaaggcatc  gactccagc  2100
tcaactgga  caacctgaa  ggcaagaag  cctgccata  tggagtaga  agaaccgcc  2160
gctggaaca  ccctatggg  ctgctgttc  gcaggatca  ccactgcaa  ttcggtgag  2220
agagccggg  agggagatt  ggaggggcc  tgcagaaaa  aaggggccc  aagaagggc  2280
ataggtttg  ggtccataa  agtgaagcc  ctcaaaaat  aacctcaag  aaataggga  2340
gaggactag  aggaaccag  ggctaagga  tggagtcag  acggttgtc  ttattgcaa  2400
taatggcat  agtggctat  cattcgctt  tctctctca  gatggagat  agaggtgag  2460
attctgtgg  tgataaggt  ttgagggct  cttccttct  tctggacca  catttccat  2520
atagtactt  cacattcaa  aagcaacct  gctgaggca  tcacaattc  ggcaagaac  2580
agagcaagt  gaaatgtac  ccaaccgtg  tcagtgttt  aaaagagcc  tctgctggg  2640
tcggtcccc  gctctga  2657



<210> 8342
<211> 2036
<212> DNA
<213> Homo sapiens
<308> AK021725
<400> 8342

acattctta  aacacagca  agtgacttt  ttctttcaa  attgtagct  agagaaaag  60
tacaggatt  aattggggg  tcaatagga  agaaatgga  agattcctt  gtgttgtag  120
agaggcatt  tcctaagga  tatagattt  tactttgca  tttcattca  catccccca  180
aatcatggt  aaggtgtag  tcactccac  cagctgatg  tcaggttat  cccttgtga  240
aattatgag  ataaagctc  caagatatg  gaaagtgct  aacacagta  ctggcacac  300
gcactcaat  aaagtttgg  tctattatg  gatggttca  ttctggttt  aggagggaa  360
aaaggttat  atatatgta  cactaagca  atatatata  atatatata  atttgggtt  420
ttttttccc  aatattatt  gggtgtccc  tgtgcttct  taggatgta  ttataacta  480
acctgttat  cttgaacat  actaagaga  gtaaattat  atgaagcta  caaaaatct  540
gaggccaaa  ttgtttctt  acagcttta  taatgcttg  tgattttga  taatccttt  600
aaaagtgga  catttgctt  ttttaatat  acgtcagta  aatgttagt  ttaaaaaga  660
cagcttttt  tggcattga  gaatgtatc  gctaagaca  aaaaattgc  tggtaagta  720
aataggtgg  ggaggaaag  ttgtaggcc  gatgaaaat  taactgact  gaacattta  780
tcaggagtg  aattatttt  ccttacccc  atccctgtg  acgtgttgg  tatagttac  840
acattatcc  gatttgcaa  tagacacaa  tttcagtct  accctgttt  ttgtttaag  900
gtgatagac  gttgtcctc  tgctggtgg  aaatctaag  tggagccca  tcttctatg  960
tgaagttca  caggcagag  agttttctt  caagtcagc  actctgctt  gtttatttt  1020
ggttttggt  cttcacgta  gcactgtta  aaggtacaa  tgtattaat  tcactagtt  1080
tgaggcgct  gggtacatt  gtttttaat  tatttagaa  gtgcagtaa  cttttttct  1140
atttttttt  ctttttagc  aacttgtta  tttaggtcc  attattgag  tgacagtct  1200
ctgtgagaa  gagatgaca  atctactgt  agaatacca  aaatgatga  tagtttatt  1260
gagaacttt  atactcagt  gtgttttat  tattaagat  aaaatatgt  cacacatgc  1320
tgtcacatc  ctctactgt  gagttaatg  gaattttta  aaaatggaa  tgcaaccac  1380
accatatct  agagaacat  cactcctag  gagggttta  aaaagctac  aagagaata  1440
ggtagatga  aatgcaaag  gtcatgatt  ggggttatt  ttgttttat  ttaaaattt  1500
tactgctac  tttgaaaga  ttgttttta  gactatgct  tttttgtga  tgaaaagtc  1560
tctaataga  gctgtatag  agctacttt  taattgctg  caaacagct  taagtgcac  1620
ttctttgat  acacttcca  tttttgtta  acttgaatt  tctgaagcc  tttatgtac  1680
actaagcaa  taactttaa  ctttaaata  agcaaattt  catctttat  gtatttcta  1740
ttgttacaa  acatacttg  taaagtaac  tcagtcctc  aatatagct  ggaaacaat  1800
atgagatag  ctcagtctc  ccctcccac  ccttttccc  tgccatatc  aattaagca  1860
taactgatt  tattacttt  ttgccttta  actgcttat  ctttttgac  gaattctgt  1920
cctgattca  tgttttgtt  gaaatttaa  gttattttc  tactgtatt  atcatacct  1980
ttttaatct  ttttcttta  atgcaataa  tcccaaatg  attgcatat  ctttat  2036



<210> 8343
<211> 3945
<212> DNA
<213> Rattus norvegicus
<308> U32314
<400> 8343

cgcggcggc  acggcttga  gcgacgggg  gaagatgct  aagttccaa  cagttcgag  60
gggcctgag  ctcctgggt  tccgccgat  ctccacagc  cccgttgcc  ccccaaatg  120
ccggcgtct  gagtacaag  ccatcaaga  agtaatggt  gccaacaga  gtgagattg  180
catccgagt  tttcgtgcc  gcacagagc  gggtatccg  acagtggct  tctactcgg  240
gcaggacac  ggccagatg  accggcaga  agctgatga  gcctacctt  ttggccgtg  300
gctggctcc  gtgcaagcc  acctgcaca  tccagacat  attaaggtg  ccaaggaga  360
tggtgtaga  gctgtgcac  ctggctatg  gttcctctc  gagagagca  actttgccc  420
ggcctgcca  gatgctgga  tccgattca  tggtccaag  ccagaggtg  tccgcaaga  480
gggagacaa  gtggaagcc  gggccattg  cattgctgc  ggcgttcca  tggtccctg  540
cactaattc  cccatcaat  ccctgcatg  ggcacacga  ttctctaac  cctatggtt  600
ccctattat  ttcaaggct  cctatggag  tgggggccg  ggcatgagg  ttgtgcata  660
ctacgagga  ctggaagag  attacaccc  ggcctaccc  gaggccttg  cagcctttg  720
gaatggggc  ttgtttgtg  agaaattca  tgagaagcc  agacacatt  aggtgcaga  780
cctagggga  caatatggg  acatcttgc  cttgtatga  cgggactgc  ccatccagc  840
gcggcacca  aaggtggta  agattgccc  tgctaccca  ctggacccc  aacttcggt  900
acgcctcac  agtgactct  tcaaacttg  caagcaggt  ggctatgag  atgcaggca  960
tgtggagtt  ctggtggac  agcatggca  gcactactt  atcgaggtc  attcccgcc  1020
gcaggtgga  cacacggtc  ctgaggaga  tacagatgt  gacctggtc  atgctcaga  1080
ccatgtgtc  gaaggccgg  gcctgcctg  cctaggcct  cggcaggaa  acatccgaa  1140
caatggttg  gccattcag  gtcgggtca  cactgagga  cctgcacgc  gcttccagc  1200
agacactgg  cgcattgag  ttttccgga  tggtgaggg  atgggcatc  gcctggaca  1260
tgcctcagc  ttccaggga  ctgtcatat  cccccacta  gactccctg  tcgtcaaag  1320
cattgccca  ggcaaagac  accctacag  tgccaccaa  atgagcaga  ccctggcgg  1380
gttccgtgt  cgaggtgta  agaccaaca  ccccttcct  cagaatgtg  tcaacaacc  1440
gcagttcct  gcgggcatt  tggacaccc  gttcatcga  gagaacccc  agctgttcc  1500
gctgcggcc  gcacagaac  gggcccaga  gttgctaca  taccttgga  acgtcatgg  1560
caatggccc  accactcca  tccccgtca  ggtcagtcc  agccctgtg  accccattg  1620
tcctgtggt  cccataggc  cacccccag  tggtttcag  gacatcctt  tgcgagagg  1680
gccagaggg  tttgccaga  ctgtgcgga  tcaccaggg  ctgctgcta  tggacacaa  1740
cttccggga  gcccaccag  cactacttg  cactagagt  cgcacacac  atctcaaaa  1800
gattgcacc  tacgttgcc  acaacttca  caacctctt  agcatagag  actggggag  1860
agccacatt  gacgtggcc  tgcgcttct  gtatgagtg  ccctggcgg  ggctccagg  1920
gctccggga  ctcatcccc  acatcccat  ccagatgct  ctgaggggg  ccaatgctg  1980
gggctacac  aactaccct  acaacgtgg  cttcaagtt  tgtgaggtg  ccaaagaga  2040
tggcatgga  gtcttccgg  tctttgact  ccttaacta  ctgccaaac  tgctgctgg  2100
catggaagc  gctggcagt  ctgggggtg  ggtggaagc  gccatctcc  acacgggtg  2160
cgtggctga  cccagtcgc  ctaaatact  actggagta  tacatgggc  tagctgaag  2220
actggtgcg  gccggcact  acatcctct  cattaagga  atggcaggc  tgctgaagc  2280
tgcagcatg  accatgctg  tcagctccc  ccgggaccg  ttccccgac  tcccactgc  2340
catccatac  catgacaca  cagggtcag  tgtggcagc  atgttggcc  gtgcacaag  2400
tggggctga  gttgtggat  tggcagtcg  ctctatgtc  gggatgacc  cacagccca  2460
catgggggc  ctggtggcc  gtaccaaag  gactcctct  gacacagag  tacccctgg  2520
gcgtgtgtt  gactacagt  agtattggg  aggggctcg  gggctgtat  cagcctttg  2580
ttgcacggc  accatgaag  ctggcaact  agacgtgta  gagaatgag  atccagggg  2640
ccagtacac  aacctacac  tccaggccc  cagcatggg  cttggctcc  agttcaagg  2700
ggtcaagaa  gcctatgtg  aggctaacc  gatgctggg  gacctcatc  aggtgacac  2760
atcctccaa  attgtgggg  atctggccc  gttcatggt  cagaacggg  tgagccggg  2820
agaggcaga  gctcaggca  aagagctgt  cttcccccg  tctgtggtg  agttcctgc  2880
gggctacat  ggcattccc  atgggggtt  ccctgaacc  ttccgttct  aggtgctaa  2940
ggacctgcc  aggatagaa  gagggcctg  agcctccct  cctcccttg  acctgaagg  3000
gctggagaa  gacctgatt  ataggcatg  agaggaggt  accccagag  acgttctct  3060
tgcagccat  taccctgat  tctttgctc  gttcaaaga  ttcacggct  cctttggcc  3120
cctggatag  ctgaatact  gtctctttc  tcaaggacc  aaaattgca  aggagtttg  3180
ggttgagct  gaacggggc  agaccttgc  catcaaagc  ctggctgta  gcgacctga  3240
ccgtgctgg  cagaggcag  tgttctttg  actcaatgg  cagcttcga  ccattctgg  3300
taaagacac  caggccatg  aggagatgc  cttccatcc  aaggccttg  aggatgtga  3360
gggccaaat  ggggcccct  tgcctggga  ggtcataga  gtcaaggtg  cagcaggag  3420
caaggtggt  aagggccag  ccctctgtg  gctcagcgc  atgaagatg  agactgtgg  3480
gacttcgcc  atggagggc  ctatccgaa  ggttcacgt  accaaggac  tgactctgg  3540
aggcgatga  ctcatccta  agattgagt  atcttactc  agactggca  cctggccaa  3600
cctacccca  gcctctcaa  agaagctgt  cagccaggg  aggcccagg  agtacctga  3660
ggctaggcc  tgaggtcct  tcccatggg  cagcacaca  actacctgc  atggccctc  3720
cattccctt  agctatttg  ccttgtctt  ctggcaggc  gttctcaca  attcatctc  3780
tgccaaata  gggtctgct  ctcgtggga  accacaggt  tacagtagg  ggccttgta  3840
ctgggagag  ggttctacc  ctgggggta  agggaagaa  acctaattc  taggtcctg  3900
gaaatttgc  caataaaag  ggccttccc  tgccctcca  aaaaa  3945



<210> 8344
<211> 1178
<212> PRT
<213> Rattus norvegicus
<308> P52873
<400> 8344

Met Leu Lys Phe Gln Thr Val Arg Gly Gly Leu Arg Leu Leu Gly Val 
  1               5                  10                  15
Arg Arg Ser Ser Thr Ala Pro Val Ala Ser Pro Asn Val Arg Arg Leu 
             20                  25                  30
Glu Tyr Lys Pro Ile Lys Lys Val Met Val Ala Asn Arg Gly Glu Ile 
         35                  40                  45
Ala Ile Arg Val Phe Arg Ala Cys Thr Glu Leu Gly Ile Arg Thr Val 
     50                  55                  60
Ala Val Tyr Ser Glu Gln Asp Thr Gly Gln Met His Arg Gln Lys Ala 
 65                  70                  75                  80
Asp Glu Ala Tyr Leu Ile Gly Arg Gly Leu Ala Pro Val Gln Ala Tyr 
                 85                  90                  95
Leu His Ile Pro Asp Ile Ile Lys Val Ala Lys Glu Asn Gly Val Asp 
             100                105                110
Ala Val His Pro Gly Tyr Gly Phe Leu Ser Glu Arg Ala Asp Phe Ala 
         115                120                125
Gln Ala Cys Gln Asp Ala Gly Val Arg Phe Ile Gly Pro Ser Pro Glu 
     130                135                140
Val Val Arg Lys Met Gly Asp Lys Val Glu Ala Arg Ala Ile Ala Ile 
 145                150                155                160
Ala Ala Gly Val Pro Val Val Pro Gly Thr Asn Ser Pro Ile Asn Ser 
                 165                170                175
Leu His Glu Ala His Glu Phe Ser Asn Thr Tyr Gly Phe Pro Ile Ile 
             180                185                190
Phe Lys Ala Ala Tyr Gly Gly Gly Gly Arg Gly Met Arg Val Val His 
         195                200                205
Ser Tyr Glu Glu Leu Glu Glu Asn Tyr Thr Arg Ala Tyr Pro Glu Ala 
     210                215                220
Leu Ala Ala Phe Gly Asn Gly Ala Leu Phe Val Glu Lys Phe Ile Glu 
 225                230                235                240
Lys Pro Arg His Ile Glu Val Gln Ile Leu Gly Asp Gln Tyr Gly Asn 
                 245                250                255
Ile Leu His Leu Tyr Glu Arg Asp Cys Ser Ile Gln Arg Arg His Gln 
             260                265                270
Lys Val Val Glu Ile Ala Pro Ala Thr His Leu Asp Pro Gln Leu Arg 
         275                280                285
Ser Arg Leu Thr Ser Asp Ser Val Lys Leu Ala Lys Gln Val Gly Tyr 
     290                295                300
Glu Asn Ala Gly Thr Val Glu Phe Leu Val Asp Lys His Gly Lys His 
 305                310                315                320
Tyr Phe Ile Glu Val Asn Ser Arg Leu Gln Val Glu His Thr Val Thr 
                 325                330                335
Glu Glu Ile Thr Asp Val Asp Leu Val His Ala Gln Ile His Val Ser 
             340                345                350
Glu Gly Arg Ser Leu Pro Asp Leu Gly Leu Arg Gln Glu Asn Ile Arg 
         355                360                365
Ile Asn Gly Cys Ala Ile Gln Cys Arg Val Thr Thr Glu Asp Pro Ala 
     370                375                380
Arg Ser Phe Gln Pro Asp Thr Gly Arg Ile Glu Val Phe Arg Ser Gly 
 385                390                395                400
Glu Gly Met Gly Ile Arg Leu Asp Asn Ala Ser Ala Phe Gln Gly Ala 
                 405                410                415
Val Ile Ser Pro His Tyr Asp Ser Leu Leu Val Lys Val Ile Ala His 
             420                425                430
Gly Lys Asp His Pro Thr Ala Ala Thr Lys Met Ser Arg Ala Leu Ala 
         435                440                445
Glu Phe Arg Val Arg Gly Val Lys Thr Asn Ile Pro Phe Leu Gln Asn 
     450                455                460
Val Leu Asn Asn Gln Gln Phe Leu Ala Gly Ile Val Asp Thr Gln Phe 
 465                470                475                480
Ile Asp Glu Asn Pro Glu Leu Phe Gln Leu Arg Pro Ala Gln Asn Arg 
                 485                490                495
Ala Gln Lys Leu Leu His Tyr Leu Gly His Val Met Val Asn Gly Pro 
             500                505                510
Thr Thr Pro Ile Pro Val Lys Val Ser Pro Ser Pro Val Asp Pro Ile 
         515                520                525
Val Pro Val Val Pro Ile Gly Pro Pro Pro Ala Gly Phe Arg Asp Ile 
     530                535                540
Leu Leu Arg Glu Gly Pro Glu Gly Phe Ala Arg Ala Val Arg Asn His 
 545                550                555                560
Gln Gly Leu Leu Leu Met Asp Thr Thr Phe Arg Asp Ala His Gln Ser 
                 565                570                575
Leu Leu Ala Thr Arg Val Arg Thr His Asp Leu Lys Lys Ile Ala Pro 
             580                585                590
Tyr Val Ala His Asn Phe Asn Asn Leu Phe Ser Ile Glu Asn Trp Gly 
         595                600                605
Gly Ala Thr Phe Asp Val Ala Met Arg Phe Leu Tyr Glu Cys Pro Trp 
     610                615                620
Arg Arg Leu Gln Glu Leu Arg Glu Leu Ile Pro Asn Ile Pro Phe Gln 
 625                630                635                640
Met Leu Leu Arg Gly Ala Asn Ala Val Gly Tyr Thr Asn Tyr Pro Asp 
                 645                650                655
Asn Val Val Phe Lys Phe Cys Glu Val Ala Lys Glu Asn Gly Met Asp 
             660                665                670
Val Phe Arg Ile Phe Asp Ser Leu Asn Tyr Leu Pro Asn Met Leu Leu 
         675                680                685
Gly Met Glu Ala Ala Gly Ser Ala Gly Gly Val Val Glu Ala Ala Ile 
     690                695                700
Ser Tyr Thr Gly Asp Val Ala Asp Pro Ser Arg Thr Lys Tyr Ser Leu 
 705                710                715                720
Glu Tyr Tyr Met Gly Leu Ala Glu Glu Leu Val Arg Ala Gly Thr His 
                 725                730                735
Ile Leu Cys Ile Lys Asp Met Ala Gly Leu Leu Lys Pro Ala Ala Cys 
             740                745                750
Thr Met Leu Val Ser Ser Leu Arg Asp Arg Phe Pro Asp Leu Pro Leu 
         755                760                765
His Ile His Thr His Asp Thr Ser Gly Ser Gly Val Ala Ala Met Leu 
     770                775                780
Ala Cys Ala Gln Ala Gly Ala Asp Val Val Asp Val Ala Val Asp Ser 
 785                790                795                800
Met Ser Gly Met Thr Ser Gln Pro Ser Met Gly Ala Leu Val Ala Cys 
                 805                810                815
Thr Lys Gly Thr Pro Leu Asp Thr Glu Val Pro Leu Glu Arg Val Phe 
             820                825                830
Asp Tyr Ser Glu Tyr Trp Glu Gly Ala Arg Gly Leu Tyr Ala Ala Phe 
         835                840                845
Asp Cys Thr Ala Thr Met Lys Ser Gly Asn Ser Asp Val Tyr Glu Asn 
     850                855                860
Glu Asp Pro Gly Gly Gln Tyr Thr Asn Leu His Phe Gln Ala His Ser 
 865                870                875                880
Met Gly Leu Gly Ser Lys Phe Lys Glu Val Lys Lys Ala Tyr Val Glu 
                 885                890                895
Ala Asn Gln Met Leu Gly Asp Leu Ile Lys Val Thr Pro Ser Ser Lys 
             900                905                910
Ile Val Gly Asp Leu Ala Gln Phe Met Val Gln Asn Gly Leu Ser Arg 
         915                920                925
Ala Glu Ala Glu Ala Gln Ala Glu Glu Leu Ser Phe Pro Arg Ser Val 
     930                935                940
Val Glu Phe Leu Gln Gly Tyr Ile Gly Ile Pro His Gly Gly Phe Pro 
 945                950                955                960
Glu Pro Phe Arg Ser Lys Val Leu Lys Asp Leu Pro Arg Ile Glu Gly 
                 965                970                975
Gly Pro Gly Ala Ser Leu Pro Pro Leu Asn Leu Lys Glu Leu Glu Lys 
             980                985                990
Asp Leu Ile Asp Arg His Gly Glu Glu Val Thr Pro Glu Asp Val Leu 
         995                1000                1005
Ser Ala Ala Met Tyr Pro Asp Val Phe Ala Gln Phe Lys Asp Phe Thr 
     1010                1015                1020
Ala Thr Phe Gly Pro Leu Asp Ser Leu Asn Thr Arg Leu Phe Leu Gln 
 1025                1030                1035                1040
Gly Pro Lys Ile Ala Glu Glu Phe Glu Val Glu Leu Glu Arg Gly Lys 
                 1045                1050                1055
Thr Leu His Ile Lys Ala Leu Ala Val Ser Asp Leu Asn Arg Ala Gly 
             1060                1065                1070
Gln Arg Gln Val Phe Phe Glu Leu Asn Gly Gln Leu Arg Ser Ile Leu 
         1075                1080                1085
Val Lys Asp Thr Gln Ala Met Lys Glu Met His Phe His Pro Lys Ala 
     1090                1095                1100
Leu Lys Asp Val Lys Gly Gln Ile Gly Ala Pro Met Pro Gly Lys Val 
 1105                1110                1115                1120
Ile Asp Val Lys Val Ala Ala Gly Ala Lys Val Val Lys Gly Gln Pro 
                 1125                1130                1135
Leu Cys Val Leu Ser Ala Met Lys Met Glu Thr Val Val Thr Ser Pro 
             1140                1145                1150
Met Glu Gly Thr Ile Arg Lys Val His Val Thr Lys Asp Met Thr Leu 
         1155                1160                1165
Glu Gly Asp Asp Leu Ile Leu Glu Ile Glu 
     1170                1175



<210> 8345
<211> 4058
<212> DNA
<213> Homo sapiens
<308> BC011617
<400> 8345

ggcacgagg  agcagcggt  gaggcggcg  cgaggactg  cgacggcga  gagatagtg  60
ctgccttct  gagagctga  caaacacta  ggatgctga  gttccgaac  gtccatggg  120
gcctgaggc  cctgggaat  cgccgaacc  ccaccgccc  cgctgcctc  ccaaatgtc  180
ggcgcctgg  gtataagcc  atcaagaaa  tcatggtgg  caacagagg  gagattgcc  240
tccgtgtgt  ccgggcctg  acggagctg  gcatccgca  cgtagccat  tactctgag  300
aggacacgg  ccagatgca  cggcagaaa  cagatgaag  ctatctcat  ggccgcggc  360
tggcccccg  gcaggccta  ctgcacatc  cagacatca  caaggtggc  aaggagaac  420
acgtagatg  agtgcaccc  ggctacggg  tcctctctg  gcgagcgga  ttcgcccag  480
cctgccagg  tgcaggggt  cggtttatt  ggccaagcc  agaagtggt  cgcaagatg  540
gagacaagg  ggaggcccg  gccatcgcc  ttgctgcgg  tgttcccgt  gtccctggc  600
cagatgccc  catcacgtc  ctgcatgag  cccacgagt  ctccaacac  tacggcttc  660
ccatcatct  caaggcggc  tatgggggt  gagggcgtg  catgagggt  gtgcacagc  720
acgaggagc  ggaggagaa  tacacccgg  cctactcag  ggctctggc  gcctttggg  780
atggggcgc  gtttgtgga  aagttcatc  agaagccac  gcacatcga  gtgcagatc  840
tgggggacc  gtatgggaa  atcctgcac  tgtacgagc  agactgctc  atccagcgg  900
ggcaccaga  ggtggtcga  attgccccc  ccgcccacc  ggacccgca  cttcggact  960
ggctcacca  cgactctgt  aaactcgct  aacaggtgg  ctacgagaa  gcaggcacc  1020
tggagttcc  ggtggacag  cacggcaag  actacttca  cgaggtcaa  tcccgcctg  1080
aggtggagc  cacggtcac  gaggagatc  ccgacgtag  cctggtcca  gctcagatc  1140
acgtggctg  gggcaggag  ctacccgac  tgggcctgc  gcaggagaa  atccgcatc  1200
acgggtgtg  catccagtg  cgggtcacc  ccgaggacc  cgcgcgcag  ttccagccg  1260
acaccggcc  cattgaggt  ttccggagc  gagagggca  gggcatccg  ctggataat  1320
cttccgcct  ccaaggagc  gtcatctcg  cccactacg  ctccctgct  gtcaaagtc  1380
ttgcccacg  caaagacca  cccacggcc  ccaccaaga  gagcagggc  cttgcggag  1440
tccgcgtcc  aggtgtgaa  accaacatc  ccttcctgc  gaatgtgct  aacaaccag  1500
agttcctgg  aggcactgt  gacacccag  tcatcgacg  gaacccaga  ctgttccag  1560
tgcggcctg  acagaaccg  gcccaaaag  tgttgcact  cctcggcca  gtcatggta  1620
acggtccaa  caccccgat  cccgtcaag  ccagcccca  ccccacgga  cccgttgtc  1680
ctgcagtgc  cataggccc  cccccggct  gtttcagag  catcctgct  cgagagggg  1740
ctgagggct  tgctcgagc  gtgcggaac  acccggggc  gctgctgat  gacacgacc  1800
tcagggacg  ccaccagtc  ctgctggcc  ctcgtgtgc  cacccacga  ctcaaaaag  1860
tcgccccct  tgttgccca  aacttcagc  agctcttca  catggagaa  tggggagga  1920
ccacgtttg  cgtcgccat  cgcttcctg  atgagtgcc  ctggcggcg  ctgcaggag  1980
tccgggagc  catccccaa  atccctttc  agatgctgc  gcggggggc  aatgctgtg  2040
gctacacca  ctacccaga  aacgtggtc  tcaagttct  tgaagtggc  aaagagaat  2100
gcatggatg  cttccgtgt  tttgactcc  tcaactact  gcccaacat  ctgctgggc  2160
tggaggcgg  aggaagtgc  ggaggcgtg  tggaggctg  catctcata  acgggcgac  2220
tggccgacc  cagccgcac  aagtactca  tgcagtact  catgggctt  gccgaagag  2280
tggtgcgag  tggcaccca  atcctgtgc  tcaaggaca  ggccgggct  ctgaagccc  2340
cggcctgca  catgctggt  agctccctc  gggaccgct  ccccgacct  ccactgcac  2400
tccacaccc  cgacacgtc  ggggcaggc  tggcagcca  gctggcctg  gcccaggct  2460
gagctgatg  ggtggatgt  gcagctgat  ccatgtctg  gatgacttc  cagcccagc  2520
tgggggccc  ggtggcctg  accagaggg  ctcccctgg  cacagaggt  cccatggag  2580
gcgtgtttg  ctacagtga  tactgggag  gggctcggg  actgtacgc  gccttcgac  2640
gcacggcca  catgaagtc  ggcaactcg  acgtgtatg  aaatgagat  ccagggggc  2700
agtacacca  cctgcactt  caggcccac  gcatggggc  tggctccaa  ttcaaggag  2760
tcaagaagg  ctatgtgga  gccaaccag  tgctgggcg  tctcatcaa  gtgacgccc  2820
cctccaaga  cgtggggga  ctggcccag  ttatggtgc  gaatggatt  agccgggca  2880
aggccgaag  tcaggcgga  gagctgtcc  ttccccgct  cgtggtgga  ttcctgcag  2940
gctacatcg  tgtccccca  ggggggttc  ccgaaccct  tcgctctaa  gtactgaag  3000
acctgccaa  ggtggaggg  cggcctgga  cctccctcc  tcccctgga  ctgcaggca  3060
tggagaagg  gctggtaga  cggcatggg  aggaggtga  gccggaaga  gtgctctca  3120
cagctatgt  ccccgatgt  tttgcccac  tcaaggact  cactgccac  tttggcccc  3180
tggatagcc  gaatactcg  ctcttcctg  agggaccca  gatcgcaga  gagtttgag  3240
tggagctgg  gcggggcaa  acgctgcac  tcaaagccc  ggccgtgag  gacctgaac  3300
gggccggcc  gaggcaggt  ttctttgag  tcaatgggc  gctgcggtc  atcttggtc  3360
aggacaccc  ggccatgaa  gagatgcac  tccacccca  ggccctaaa  gacgtgaag  3420
gccagatcg  ggcgcccat  cctgggaag  tgatagaca  caaagtggt  gcaggggcc  3480
aggtggcca  gggccagcc  ctgtgtgtg  tcagtgcca  gaagatgga  actgtggtg  3540
cctcaccca  ggagggtac  gtccgcaag  ttcatgtga  caaggacat  acactggaa  3600
gtgacgacc  catcctgga  atcgagtga  cttgcccca  accggcagc  tggccatcc  3660
caagccttc  acagaagct  tgctgccac  gcaggccca  gccagccag  gcccgaggc  3720
aggaaggcc  ggccgtgga  gtcctgtcc  cagctggac  ggagagaca  cgcctgcgg  3780
ggttcattc  tttcagcca  cgtcctttc  tccggcgga  agctgctta  atgttcatc  3840
cttgccaaa  aagggtccc  tcctcactg  agactacaa  tggtgggtc  ggtggtcct  3900
ggacccagg  gaggtttag  ggtcctatc  cctggggga  ggggagatc  aagatgtcc  3960
aggtcctgg  aagtttact  aataaagct  gctttcccc  gccaaaaaa  aaaaaaaaa  4020
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4058



<210> 8346
<211> 1178
<212> PRT
<213> Homo sapiens
<308> P11498
<400> 8346

Met Leu Lys Phe Arg Thr Val His Gly Gly Leu Arg Leu Leu Gly Ile 
  1               5                  10                  15
Arg Arg Thr Ser Thr Ala Pro Ala Ala Ser Pro Asn Val Arg Arg Leu 
             20                  25                  30
Glu Tyr Lys Pro Ile Lys Lys Val Met Val Ala Asn Arg Gly Glu Ile 
         35                  40                  45
Ala Ile Arg Val Phe Arg Ala Cys Thr Glu Leu Gly Ile Arg Thr Val 
     50                  55                  60
Ala Ile Tyr Ser Glu Gln Asp Thr Gly Gln Met His Arg Gln Lys Ala 
 65                  70                  75                  80
Asp Glu Ala Tyr Leu Ile Gly Arg Gly Leu Ala Pro Val Gln Ala Tyr 
                 85                  90                  95
Leu His Ile Pro Asp Ile Ile Lys Val Ala Lys Glu Asn Asn Val Asp 
             100                105                110
Ala Val His Pro Gly Tyr Gly Phe Leu Ser Glu Arg Ala Asp Phe Ala 
         115                120                125
Gln Ala Cys Gln Asp Ala Gly Val Arg Phe Ile Gly Pro Ser Pro Glu 
     130                135                140
Val Val Arg Lys Met Gly Asp Lys Val Glu Ala Arg Ala Ile Ala Ile 
 145                150                155                160
Ala Ala Gly Val Pro Val Val Pro Gly Thr Asp Ala Pro Ile Thr Ser 
                 165                170                175
Leu His Glu Ala His Glu Phe Ser Asn Thr Tyr Gly Phe Pro Ile Ile 
             180                185                190
Phe Lys Ala Ala Tyr Gly Gly Gly Gly Arg Gly Met Arg Val Val His 
         195                200                205
Ser Tyr Glu Glu Leu Glu Glu Asn Tyr Thr Arg Ala Tyr Ser Glu Ala 
     210                215                220
Leu Ala Ala Phe Gly Asn Gly Ala Leu Phe Val Glu Lys Phe Ile Glu 
 225                230                235                240
Lys Pro Arg His Ile Glu Val Gln Ile Leu Gly Asp Gln Tyr Gly Asn 
                 245                250                255
Ile Leu His Leu Tyr Glu Arg Asp Cys Ser Ile Gln Arg Arg His Gln 
             260                265                270
Lys Val Val Glu Ile Ala Pro Ala Ala His Leu Asp Pro Gln Leu Arg 
         275                280                285
Thr Arg Leu Thr Ser Asp Ser Val Lys Leu Ala Lys Gln Val Gly Tyr 
     290                295                300
Glu Asn Ala Gly Thr Val Glu Phe Leu Val Asp Arg His Gly Lys His 
 305                310                315                320
Tyr Phe Ile Glu Val Asn Ser Arg Leu Gln Val Glu His Thr Val Thr 
                 325                330                335
Glu Glu Ile Thr Asp Val Asp Leu Val His Ala Gln Ile His Val Ala 
             340                345                350
Glu Gly Arg Ser Leu Pro Asp Leu Gly Leu Arg Gln Glu Asn Ile Arg 
         355                360                365
Ile Asn Gly Cys Ala Ile Gln Cys Arg Val Thr Thr Glu Asp Pro Ala 
     370                375                380
Arg Ser Phe Gln Pro Asp Thr Gly Arg Ile Glu Val Phe Arg Ser Gly 
 385                390                395                400
Glu Gly Met Gly Ile Arg Leu Asp Asn Ala Ser Ala Phe Gln Gly Ala 
                 405                410                415
Val Ile Ser Pro His Tyr Asp Ser Leu Leu Val Lys Val Ile Ala His 
             420                425                430
Gly Lys Asp His Pro Thr Ala Ala Thr Lys Met Ser Arg Ala Leu Ala 
         435                440                445
Glu Phe Arg Val Arg Gly Val Lys Thr Asn Ile Ala Phe Leu Gln Asn 
     450                455                460
Val Leu Asn Asn Gln Gln Phe Leu Ala Gly Thr Val Asp Thr Gln Phe 
 465                470                475                480
Ile Asp Glu Asn Pro Glu Leu Phe Gln Leu Arg Pro Ala Gln Asn Arg 
                 485                490                495
Ala Gln Lys Leu Leu His Tyr Leu Gly His Val Met Val Asn Gly Pro 
             500                505                510
Thr Thr Pro Ile Pro Val Lys Ala Ser Pro Ser Pro Thr Asp Pro Val 
         515                520                525
Val Pro Ala Val Pro Ile Gly Pro Pro Pro Ala Gly Phe Arg Asp Ile 
     530                535                540
Leu Leu Arg Glu Gly Pro Glu Gly Phe Ala Arg Ala Val Arg Asn His 
 545                550                555                560
Pro Gly Leu Leu Leu Met Asp Thr Thr Phe Arg Asp Ala His Gln Ser 
                 565                570                575
Leu Leu Ala Thr Arg Val Arg Thr His Asp Leu Lys Lys Ile Ala Pro 
             580                585                590
Tyr Val Ala His Asn Phe Ser Lys Leu Phe Ser Met Glu Asn Trp Gly 
         595                600                605
Gly Ala Thr Phe Asp Val Ala Met Arg Phe Leu Tyr Glu Cys Pro Trp 
     610                615                620
Arg Arg Leu Gln Glu Leu Arg Glu Leu Ile Pro Asn Ile Pro Phe Gln 
 625                630                635                640
Met Leu Leu Arg Gly Ala Asn Ala Val Gly Tyr Thr Asn Tyr Pro Asp 
                 645                650                655
Asn Val Val Phe Lys Phe Cys Glu Val Ala Lys Glu Asn Gly Met Asp 
             660                665                670
Val Phe Arg Val Phe Asp Ser Leu Asn Tyr Leu Pro Asn Met Leu Leu 
         675                680                685
Gly Met Glu Ala Ala Gly Ser Ala Gly Gly Val Val Glu Ala Ala Ile 
     690                695                700
Ser Tyr Thr Gly Asp Val Ala Asp Pro Ser Arg Thr Lys Tyr Ser Leu 
 705                710                715                720
Gln Tyr Tyr Met Gly Leu Ala Glu Glu Leu Val Arg Ala Gly Thr His 
                 725                730                735
Ile Leu Cys Ile Lys Asp Met Ala Gly Leu Leu Lys Pro Thr Ala Cys 
             740                745                750
Thr Met Leu Val Ser Ser Leu Arg Asp Arg Phe Pro Asp Leu Pro Leu 
         755                760                765
His Ile His Thr His Asp Thr Ser Gly Ala Gly Val Ala Ala Met Leu 
     770                775                780
Ala Cys Ala Gln Ala Gly Ala Asp Val Val Asp Val Ala Ala Asp Ser 
 785                790                795                800
Met Ser Gly Met Thr Ser Gln Pro Ser Met Gly Ala Leu Val Ala Cys 
                 805                810                815
Thr Arg Gly Thr Pro Leu Asp Thr Glu Val Pro Met Glu Arg Val Phe 
             820                825                830
Asp Tyr Ser Glu Tyr Trp Glu Gly Ala Arg Gly Leu Tyr Ala Ala Phe 
         835                840                845
Asp Cys Thr Ala Thr Met Lys Ser Gly Asn Ser Asp Val Tyr Glu Asn 
     850                855                860
Glu Ile Pro Gly Gly Gln Tyr Thr Asn Leu His Phe Gln Ala His Ser 
 865                870                875                880
Met Gly Leu Gly Ser Lys Phe Lys Glu Val Lys Lys Ala Tyr Val Glu 
                 885                890                895
Ala Asn Gln Met Leu Gly Asp Leu Ile Lys Val Thr Pro Ser Ser Lys 
             900                905                910
Ile Val Gly Asp Leu Ala Gln Phe Met Val Gln Asn Gly Leu Ser Arg 
         915                920                925
Ala Glu Ala Glu Ala Gln Ala Glu Glu Leu Ser Phe Pro Arg Ser Val 
     930                935                940
Val Glu Phe Leu Gln Gly Tyr Ile Gly Val Pro His Gly Gly Phe Pro 
 945                950                955                960
Glu Pro Phe Arg Ser Lys Val Leu Lys Asp Leu Pro Arg Val Glu Gly 
                 965                970                975
Arg Pro Gly Ala Ser Leu Pro Pro Leu Asp Leu Gln Ala Leu Glu Lys 
             980                985                990
Glu Leu Val Asp Arg His Gly Glu Glu Val Thr Pro Glu Asp Val Leu 
         995                1000                1005
Ser Ala Ala Met Tyr Pro Asp Val Phe Ala His Phe Lys Asp Phe Thr 
     1010                1015                1020
Ala Thr Phe Gly Pro Leu Asp Ser Leu Asn Thr Arg Leu Phe Leu Gln 
 1025                1030                1035                1040
Gly Pro Lys Ile Ala Glu Glu Phe Glu Val Glu Leu Glu Arg Gly Lys 
                 1045                1050                1055
Thr Leu His Ile Lys Ala Leu Ala Val Ser Asp Leu Asn Arg Ala Gly 
             1060                1065                1070
Gln Arg Gln Val Phe Phe Glu Leu Asn Gly Gln Leu Arg Ser Ile Leu 
         1075                1080                1085
Val Lys Asp Thr Gln Ala Met Lys Glu Met His Phe His Pro Lys Ala 
     1090                1095                1100
Leu Lys Asp Val Lys Gly Gln Ile Gly Ala Pro Met Pro Gly Lys Val 
 1105                1110                1115                1120
Ile Asp Ile Lys Val Val Ala Gly Ala Lys Val Ala Lys Gly Gln Pro 
                 1125                1130                1135
Leu Cys Val Leu Ser Ala Met Lys Met Glu Thr Val Val Thr Ser Pro 
             1140                1145                1150
Met Glu Gly Thr Val Arg Lys Val His Val Thr Lys Asp Met Thr Leu 
         1155                1160                1165
Glu Gly Asp Asp Leu Ile Leu Glu Ile Glu 
     1170                1175



<210> 8347
<211> 3945
<212> DNA
<213> Rattus norvegicus
<308> U32314
<400> 8347

cgcggcggc  acggcttga  gcgacgggg  gaagatgct  aagttccaa  cagttcgag  60
gggcctgag  ctcctgggt  tccgccgat  ctccacagc  cccgttgcc  ccccaaatg  120
ccggcgtct  gagtacaag  ccatcaaga  agtaatggt  gccaacaga  gtgagattg  180
catccgagt  tttcgtgcc  gcacagagc  gggtatccg  acagtggct  tctactcgg  240
gcaggacac  ggccagatg  accggcaga  agctgatga  gcctacctt  ttggccgtg  300
gctggctcc  gtgcaagcc  acctgcaca  tccagacat  attaaggtg  ccaaggaga  360
tggtgtaga  gctgtgcac  ctggctatg  gttcctctc  gagagagca  actttgccc  420
ggcctgcca  gatgctgga  tccgattca  tggtccaag  ccagaggtg  tccgcaaga  480
gggagacaa  gtggaagcc  gggccattg  cattgctgc  ggcgttcca  tggtccctg  540
cactaattc  cccatcaat  ccctgcatg  ggcacacga  ttctctaac  cctatggtt  600
ccctattat  ttcaaggct  cctatggag  tgggggccg  ggcatgagg  ttgtgcata  660
ctacgagga  ctggaagag  attacaccc  ggcctaccc  gaggccttg  cagcctttg  720
gaatggggc  ttgtttgtg  agaaattca  tgagaagcc  agacacatt  aggtgcaga  780
cctagggga  caatatggg  acatcttgc  cttgtatga  cgggactgc  ccatccagc  840
gcggcacca  aaggtggta  agattgccc  tgctaccca  ctggacccc  aacttcggt  900
acgcctcac  agtgactct  tcaaacttg  caagcaggt  ggctatgag  atgcaggca  960
tgtggagtt  ctggtggac  agcatggca  gcactactt  atcgaggtc  attcccgcc  1020
gcaggtgga  cacacggtc  ctgaggaga  tacagatgt  gacctggtc  atgctcaga  1080
ccatgtgtc  gaaggccgg  gcctgcctg  cctaggcct  cggcaggaa  acatccgaa  1140
caatggttg  gccattcag  gtcgggtca  cactgagga  cctgcacgc  gcttccagc  1200
agacactgg  cgcattgag  ttttccgga  tggtgaggg  atgggcatc  gcctggaca  1260
tgcctcagc  ttccaggga  ctgtcatat  cccccacta  gactccctg  tcgtcaaag  1320
cattgccca  ggcaaagac  accctacag  tgccaccaa  atgagcaga  ccctggcgg  1380
gttccgtgt  cgaggtgta  agaccaaca  ccccttcct  cagaatgtg  tcaacaacc  1440
gcagttcct  gcgggcatt  tggacaccc  gttcatcga  gagaacccc  agctgttcc  1500
gctgcggcc  gcacagaac  gggcccaga  gttgctaca  taccttgga  acgtcatgg  1560
caatggccc  accactcca  tccccgtca  ggtcagtcc  agccctgtg  accccattg  1620
tcctgtggt  cccataggc  cacccccag  tggtttcag  gacatcctt  tgcgagagg  1680
gccagaggg  tttgccaga  ctgtgcgga  tcaccaggg  ctgctgcta  tggacacaa  1740
cttccggga  gcccaccag  cactacttg  cactagagt  cgcacacac  atctcaaaa  1800
gattgcacc  tacgttgcc  acaacttca  caacctctt  agcatagag  actggggag  1860
agccacatt  gacgtggcc  tgcgcttct  gtatgagtg  ccctggcgg  ggctccagg  1920
gctccggga  ctcatcccc  acatcccat  ccagatgct  ctgaggggg  ccaatgctg  1980
gggctacac  aactaccct  acaacgtgg  cttcaagtt  tgtgaggtg  ccaaagaga  2040
tggcatgga  gtcttccgg  tctttgact  ccttaacta  ctgccaaac  tgctgctgg  2100
catggaagc  gctggcagt  ctgggggtg  ggtggaagc  gccatctcc  acacgggtg  2160
cgtggctga  cccagtcgc  ctaaatact  actggagta  tacatgggc  tagctgaag  2220
actggtgcg  gccggcact  acatcctct  cattaagga  atggcaggc  tgctgaagc  2280
tgcagcatg  accatgctg  tcagctccc  ccgggaccg  ttccccgac  tcccactgc  2340
catccatac  catgacaca  cagggtcag  tgtggcagc  atgttggcc  gtgcacaag  2400
tggggctga  gttgtggat  tggcagtcg  ctctatgtc  gggatgacc  cacagccca  2460
catgggggc  ctggtggcc  gtaccaaag  gactcctct  gacacagag  tacccctgg  2520
gcgtgtgtt  gactacagt  agtattggg  aggggctcg  gggctgtat  cagcctttg  2580
ttgcacggc  accatgaag  ctggcaact  agacgtgta  gagaatgag  atccagggg  2640
ccagtacac  aacctacac  tccaggccc  cagcatggg  cttggctcc  agttcaagg  2700
ggtcaagaa  gcctatgtg  aggctaacc  gatgctggg  gacctcatc  aggtgacac  2760
atcctccaa  attgtgggg  atctggccc  gttcatggt  cagaacggg  tgagccggg  2820
agaggcaga  gctcaggca  aagagctgt  cttcccccg  tctgtggtg  agttcctgc  2880
gggctacat  ggcattccc  atgggggtt  ccctgaacc  ttccgttct  aggtgctaa  2940
ggacctgcc  aggatagaa  gagggcctg  agcctccct  cctcccttg  acctgaagg  3000
gctggagaa  gacctgatt  ataggcatg  agaggaggt  accccagag  acgttctct  3060
tgcagccat  taccctgat  tctttgctc  gttcaaaga  ttcacggct  cctttggcc  3120
cctggatag  ctgaatact  gtctctttc  tcaaggacc  aaaattgca  aggagtttg  3180
ggttgagct  gaacggggc  agaccttgc  catcaaagc  ctggctgta  gcgacctga  3240
ccgtgctgg  cagaggcag  tgttctttg  actcaatgg  cagcttcga  ccattctgg  3300
taaagacac  caggccatg  aggagatgc  cttccatcc  aaggccttg  aggatgtga  3360
gggccaaat  ggggcccct  tgcctggga  ggtcataga  gtcaaggtg  cagcaggag  3420
caaggtggt  aagggccag  ccctctgtg  gctcagcgc  atgaagatg  agactgtgg  3480
gacttcgcc  atggagggc  ctatccgaa  ggttcacgt  accaaggac  tgactctgg  3540
aggcgatga  ctcatccta  agattgagt  atcttactc  agactggca  cctggccaa  3600
cctacccca  gcctctcaa  agaagctgt  cagccaggg  aggcccagg  agtacctga  3660
ggctaggcc  tgaggtcct  tcccatggg  cagcacaca  actacctgc  atggccctc  3720
cattccctt  agctatttg  ccttgtctt  ctggcaggc  gttctcaca  attcatctc  3780
tgccaaata  gggtctgct  ctcgtggga  accacaggt  tacagtagg  ggccttgta  3840
ctgggagag  ggttctacc  ctgggggta  agggaagaa  acctaattc  taggtcctg  3900
gaaatttgc  caataaaag  ggccttccc  tgccctcca  aaaaa  3945



<210> 8348
<211> 1178
<212> PRT
<213> Rattus norvegicus
<308> P52873
<400> 8348

Met Leu Lys Phe Gln Thr Val Arg Gly Gly Leu Arg Leu Leu Gly Val 
  1               5                  10                  15
Arg Arg Ser Ser Thr Ala Pro Val Ala Ser Pro Asn Val Arg Arg Leu 
             20                  25                  30
Glu Tyr Lys Pro Ile Lys Lys Val Met Val Ala Asn Arg Gly Glu Ile 
         35                  40                  45
Ala Ile Arg Val Phe Arg Ala Cys Thr Glu Leu Gly Ile Arg Thr Val 
     50                  55                  60
Ala Val Tyr Ser Glu Gln Asp Thr Gly Gln Met His Arg Gln Lys Ala 
 65                  70                  75                  80
Asp Glu Ala Tyr Leu Ile Gly Arg Gly Leu Ala Pro Val Gln Ala Tyr 
                 85                  90                  95
Leu His Ile Pro Asp Ile Ile Lys Val Ala Lys Glu Asn Gly Val Asp 
             100                105                110
Ala Val His Pro Gly Tyr Gly Phe Leu Ser Glu Arg Ala Asp Phe Ala 
         115                120                125
Gln Ala Cys Gln Asp Ala Gly Val Arg Phe Ile Gly Pro Ser Pro Glu 
     130                135                140
Val Val Arg Lys Met Gly Asp Lys Val Glu Ala Arg Ala Ile Ala Ile 
 145                150                155                160
Ala Ala Gly Val Pro Val Val Pro Gly Thr Asn Ser Pro Ile Asn Ser 
                 165                170                175
Leu His Glu Ala His Glu Phe Ser Asn Thr Tyr Gly Phe Pro Ile Ile 
             180                185                190
Phe Lys Ala Ala Tyr Gly Gly Gly Gly Arg Gly Met Arg Val Val His 
         195                200                205
Ser Tyr Glu Glu Leu Glu Glu Asn Tyr Thr Arg Ala Tyr Pro Glu Ala 
     210                215                220
Leu Ala Ala Phe Gly Asn Gly Ala Leu Phe Val Glu Lys Phe Ile Glu 
 225                230                235                240
Lys Pro Arg His Ile Glu Val Gln Ile Leu Gly Asp Gln Tyr Gly Asn 
                 245                250                255
Ile Leu His Leu Tyr Glu Arg Asp Cys Ser Ile Gln Arg Arg His Gln 
             260                265                270
Lys Val Val Glu Ile Ala Pro Ala Thr His Leu Asp Pro Gln Leu Arg 
         275                280                285
Ser Arg Leu Thr Ser Asp Ser Val Lys Leu Ala Lys Gln Val Gly Tyr 
     290                295                300
Glu Asn Ala Gly Thr Val Glu Phe Leu Val Asp Lys His Gly Lys His 
 305                310                315                320
Tyr Phe Ile Glu Val Asn Ser Arg Leu Gln Val Glu His Thr Val Thr 
                 325                330                335
Glu Glu Ile Thr Asp Val Asp Leu Val His Ala Gln Ile His Val Ser 
             340                345                350
Glu Gly Arg Ser Leu Pro Asp Leu Gly Leu Arg Gln Glu Asn Ile Arg 
         355                360                365
Ile Asn Gly Cys Ala Ile Gln Cys Arg Val Thr Thr Glu Asp Pro Ala 
     370                375                380
Arg Ser Phe Gln Pro Asp Thr Gly Arg Ile Glu Val Phe Arg Ser Gly 
 385                390                395                400
Glu Gly Met Gly Ile Arg Leu Asp Asn Ala Ser Ala Phe Gln Gly Ala 
                 405                410                415
Val Ile Ser Pro His Tyr Asp Ser Leu Leu Val Lys Val Ile Ala His 
             420                425                430
Gly Lys Asp His Pro Thr Ala Ala Thr Lys Met Ser Arg Ala Leu Ala 
         435                440                445
Glu Phe Arg Val Arg Gly Val Lys Thr Asn Ile Pro Phe Leu Gln Asn 
     450                455                460
Val Leu Asn Asn Gln Gln Phe Leu Ala Gly Ile Val Asp Thr Gln Phe 
 465                470                475                480
Ile Asp Glu Asn Pro Glu Leu Phe Gln Leu Arg Pro Ala Gln Asn Arg 
                 485                490                495
Ala Gln Lys Leu Leu His Tyr Leu Gly His Val Met Val Asn Gly Pro 
             500                505                510
Thr Thr Pro Ile Pro Val Lys Val Ser Pro Ser Pro Val Asp Pro Ile 
         515                520                525
Val Pro Val Val Pro Ile Gly Pro Pro Pro Ala Gly Phe Arg Asp Ile 
     530                535                540
Leu Leu Arg Glu Gly Pro Glu Gly Phe Ala Arg Ala Val Arg Asn His 
 545                550                555                560
Gln Gly Leu Leu Leu Met Asp Thr Thr Phe Arg Asp Ala His Gln Ser 
                 565                570                575
Leu Leu Ala Thr Arg Val Arg Thr His Asp Leu Lys Lys Ile Ala Pro 
             580                585                590
Tyr Val Ala His Asn Phe Asn Asn Leu Phe Ser Ile Glu Asn Trp Gly 
         595                600                605
Gly Ala Thr Phe Asp Val Ala Met Arg Phe Leu Tyr Glu Cys Pro Trp 
     610                615                620
Arg Arg Leu Gln Glu Leu Arg Glu Leu Ile Pro Asn Ile Pro Phe Gln 
 625                630                635                640
Met Leu Leu Arg Gly Ala Asn Ala Val Gly Tyr Thr Asn Tyr Pro Asp 
                 645                650                655
Asn Val Val Phe Lys Phe Cys Glu Val Ala Lys Glu Asn Gly Met Asp 
             660                665                670
Val Phe Arg Ile Phe Asp Ser Leu Asn Tyr Leu Pro Asn Met Leu Leu 
         675                680                685
Gly Met Glu Ala Ala Gly Ser Ala Gly Gly Val Val Glu Ala Ala Ile 
     690                695                700
Ser Tyr Thr Gly Asp Val Ala Asp Pro Ser Arg Thr Lys Tyr Ser Leu 
 705                710                715                720
Glu Tyr Tyr Met Gly Leu Ala Glu Glu Leu Val Arg Ala Gly Thr His 
                 725                730                735
Ile Leu Cys Ile Lys Asp Met Ala Gly Leu Leu Lys Pro Ala Ala Cys 
             740                745                750
Thr Met Leu Val Ser Ser Leu Arg Asp Arg Phe Pro Asp Leu Pro Leu 
         755                760                765
His Ile His Thr His Asp Thr Ser Gly Ser Gly Val Ala Ala Met Leu 
     770                775                780
Ala Cys Ala Gln Ala Gly Ala Asp Val Val Asp Val Ala Val Asp Ser 
 785                790                795                800
Met Ser Gly Met Thr Ser Gln Pro Ser Met Gly Ala Leu Val Ala Cys 
                 805                810                815
Thr Lys Gly Thr Pro Leu Asp Thr Glu Val Pro Leu Glu Arg Val Phe 
             820                825                830
Asp Tyr Ser Glu Tyr Trp Glu Gly Ala Arg Gly Leu Tyr Ala Ala Phe 
         835                840                845
Asp Cys Thr Ala Thr Met Lys Ser Gly Asn Ser Asp Val Tyr Glu Asn 
     850                855                860
Glu Asp Pro Gly Gly Gln Tyr Thr Asn Leu His Phe Gln Ala His Ser 
 865                870                875                880
Met Gly Leu Gly Ser Lys Phe Lys Glu Val Lys Lys Ala Tyr Val Glu 
                 885                890                895
Ala Asn Gln Met Leu Gly Asp Leu Ile Lys Val Thr Pro Ser Ser Lys 
             900                905                910
Ile Val Gly Asp Leu Ala Gln Phe Met Val Gln Asn Gly Leu Ser Arg 
         915                920                925
Ala Glu Ala Glu Ala Gln Ala Glu Glu Leu Ser Phe Pro Arg Ser Val 
     930                935                940
Val Glu Phe Leu Gln Gly Tyr Ile Gly Ile Pro His Gly Gly Phe Pro 
 945                950                955                960
Glu Pro Phe Arg Ser Lys Val Leu Lys Asp Leu Pro Arg Ile Glu Gly 
                 965                970                975
Gly Pro Gly Ala Ser Leu Pro Pro Leu Asn Leu Lys Glu Leu Glu Lys 
             980                985                990
Asp Leu Ile Asp Arg His Gly Glu Glu Val Thr Pro Glu Asp Val Leu 
         995                1000                1005
Ser Ala Ala Met Tyr Pro Asp Val Phe Ala Gln Phe Lys Asp Phe Thr 
     1010                1015                1020
Ala Thr Phe Gly Pro Leu Asp Ser Leu Asn Thr Arg Leu Phe Leu Gln 
 1025                1030                1035                1040
Gly Pro Lys Ile Ala Glu Glu Phe Glu Val Glu Leu Glu Arg Gly Lys 
                 1045                1050                1055
Thr Leu His Ile Lys Ala Leu Ala Val Ser Asp Leu Asn Arg Ala Gly 
             1060                1065                1070
Gln Arg Gln Val Phe Phe Glu Leu Asn Gly Gln Leu Arg Ser Ile Leu 
         1075                1080                1085
Val Lys Asp Thr Gln Ala Met Lys Glu Met His Phe His Pro Lys Ala 
     1090                1095                1100
Leu Lys Asp Val Lys Gly Gln Ile Gly Ala Pro Met Pro Gly Lys Val 
 1105                1110                1115                1120
Ile Asp Val Lys Val Ala Ala Gly Ala Lys Val Val Lys Gly Gln Pro 
                 1125                1130                1135
Leu Cys Val Leu Ser Ala Met Lys Met Glu Thr Val Val Thr Ser Pro 
             1140                1145                1150
Met Glu Gly Thr Ile Arg Lys Val His Val Thr Lys Asp Met Thr Leu 
         1155                1160                1165
Glu Gly Asp Asp Leu Ile Leu Glu Ile Glu 
     1170                1175



<210> 8349
<211> 4058
<212> DNA
<213> Homo sapiens
<308> BC011617
<400> 8349

ggcacgagg  agcagcggt  gaggcggcg  cgaggactg  cgacggcga  gagatagtg  60
ctgccttct  gagagctga  caaacacta  ggatgctga  gttccgaac  gtccatggg  120
gcctgaggc  cctgggaat  cgccgaacc  ccaccgccc  cgctgcctc  ccaaatgtc  180
ggcgcctgg  gtataagcc  atcaagaaa  tcatggtgg  caacagagg  gagattgcc  240
tccgtgtgt  ccgggcctg  acggagctg  gcatccgca  cgtagccat  tactctgag  300
aggacacgg  ccagatgca  cggcagaaa  cagatgaag  ctatctcat  ggccgcggc  360
tggcccccg  gcaggccta  ctgcacatc  cagacatca  caaggtggc  aaggagaac  420
acgtagatg  agtgcaccc  ggctacggg  tcctctctg  gcgagcgga  ttcgcccag  480
cctgccagg  tgcaggggt  cggtttatt  ggccaagcc  agaagtggt  cgcaagatg  540
gagacaagg  ggaggcccg  gccatcgcc  ttgctgcgg  tgttcccgt  gtccctggc  600
cagatgccc  catcacgtc  ctgcatgag  cccacgagt  ctccaacac  tacggcttc  660
ccatcatct  caaggcggc  tatgggggt  gagggcgtg  catgagggt  gtgcacagc  720
acgaggagc  ggaggagaa  tacacccgg  cctactcag  ggctctggc  gcctttggg  780
atggggcgc  gtttgtgga  aagttcatc  agaagccac  gcacatcga  gtgcagatc  840
tgggggacc  gtatgggaa  atcctgcac  tgtacgagc  agactgctc  atccagcgg  900
ggcaccaga  ggtggtcga  attgccccc  ccgcccacc  ggacccgca  cttcggact  960
ggctcacca  cgactctgt  aaactcgct  aacaggtgg  ctacgagaa  gcaggcacc  1020
tggagttcc  ggtggacag  cacggcaag  actacttca  cgaggtcaa  tcccgcctg  1080
aggtggagc  cacggtcac  gaggagatc  ccgacgtag  cctggtcca  gctcagatc  1140
acgtggctg  gggcaggag  ctacccgac  tgggcctgc  gcaggagaa  atccgcatc  1200
acgggtgtg  catccagtg  cgggtcacc  ccgaggacc  cgcgcgcag  ttccagccg  1260
acaccggcc  cattgaggt  ttccggagc  gagagggca  gggcatccg  ctggataat  1320
cttccgcct  ccaaggagc  gtcatctcg  cccactacg  ctccctgct  gtcaaagtc  1380
ttgcccacg  caaagacca  cccacggcc  ccaccaaga  gagcagggc  cttgcggag  1440
tccgcgtcc  aggtgtgaa  accaacatc  ccttcctgc  gaatgtgct  aacaaccag  1500
agttcctgg  aggcactgt  gacacccag  tcatcgacg  gaacccaga  ctgttccag  1560
tgcggcctg  acagaaccg  gcccaaaag  tgttgcact  cctcggcca  gtcatggta  1620
acggtccaa  caccccgat  cccgtcaag  ccagcccca  ccccacgga  cccgttgtc  1680
ctgcagtgc  cataggccc  cccccggct  gtttcagag  catcctgct  cgagagggg  1740
ctgagggct  tgctcgagc  gtgcggaac  acccggggc  gctgctgat  gacacgacc  1800
tcagggacg  ccaccagtc  ctgctggcc  ctcgtgtgc  cacccacga  ctcaaaaag  1860
tcgccccct  tgttgccca  aacttcagc  agctcttca  catggagaa  tggggagga  1920
ccacgtttg  cgtcgccat  cgcttcctg  atgagtgcc  ctggcggcg  ctgcaggag  1980
tccgggagc  catccccaa  atccctttc  agatgctgc  gcggggggc  aatgctgtg  2040
gctacacca  ctacccaga  aacgtggtc  tcaagttct  tgaagtggc  aaagagaat  2100
gcatggatg  cttccgtgt  tttgactcc  tcaactact  gcccaacat  ctgctgggc  2160
tggaggcgg  aggaagtgc  ggaggcgtg  tggaggctg  catctcata  acgggcgac  2220
tggccgacc  cagccgcac  aagtactca  tgcagtact  catgggctt  gccgaagag  2280
tggtgcgag  tggcaccca  atcctgtgc  tcaaggaca  ggccgggct  ctgaagccc  2340
cggcctgca  catgctggt  agctccctc  gggaccgct  ccccgacct  ccactgcac  2400
tccacaccc  cgacacgtc  ggggcaggc  tggcagcca  gctggcctg  gcccaggct  2460
gagctgatg  ggtggatgt  gcagctgat  ccatgtctg  gatgacttc  cagcccagc  2520
tgggggccc  ggtggcctg  accagaggg  ctcccctgg  cacagaggt  cccatggag  2580
gcgtgtttg  ctacagtga  tactgggag  gggctcggg  actgtacgc  gccttcgac  2640
gcacggcca  catgaagtc  ggcaactcg  acgtgtatg  aaatgagat  ccagggggc  2700
agtacacca  cctgcactt  caggcccac  gcatggggc  tggctccaa  ttcaaggag  2760
tcaagaagg  ctatgtgga  gccaaccag  tgctgggcg  tctcatcaa  gtgacgccc  2820
cctccaaga  cgtggggga  ctggcccag  ttatggtgc  gaatggatt  agccgggca  2880
aggccgaag  tcaggcgga  gagctgtcc  ttccccgct  cgtggtgga  ttcctgcag  2940
gctacatcg  tgtccccca  ggggggttc  ccgaaccct  tcgctctaa  gtactgaag  3000
acctgccaa  ggtggaggg  cggcctgga  cctccctcc  tcccctgga  ctgcaggca  3060
tggagaagg  gctggtaga  cggcatggg  aggaggtga  gccggaaga  gtgctctca  3120
cagctatgt  ccccgatgt  tttgcccac  tcaaggact  cactgccac  tttggcccc  3180
tggatagcc  gaatactcg  ctcttcctg  agggaccca  gatcgcaga  gagtttgag  3240
tggagctgg  gcggggcaa  acgctgcac  tcaaagccc  ggccgtgag  gacctgaac  3300
gggccggcc  gaggcaggt  ttctttgag  tcaatgggc  gctgcggtc  atcttggtc  3360
aggacaccc  ggccatgaa  gagatgcac  tccacccca  ggccctaaa  gacgtgaag  3420
gccagatcg  ggcgcccat  cctgggaag  tgatagaca  caaagtggt  gcaggggcc  3480
aggtggcca  gggccagcc  ctgtgtgtg  tcagtgcca  gaagatgga  actgtggtg  3540
cctcaccca  ggagggtac  gtccgcaag  ttcatgtga  caaggacat  acactggaa  3600
gtgacgacc  catcctgga  atcgagtga  cttgcccca  accggcagc  tggccatcc  3660
caagccttc  acagaagct  tgctgccac  gcaggccca  gccagccag  gcccgaggc  3720
aggaaggcc  ggccgtgga  gtcctgtcc  cagctggac  ggagagaca  cgcctgcgg  3780
ggttcattc  tttcagcca  cgtcctttc  tccggcgga  agctgctta  atgttcatc  3840
cttgccaaa  aagggtccc  tcctcactg  agactacaa  tggtgggtc  ggtggtcct  3900
ggacccagg  gaggtttag  ggtcctatc  cctggggga  ggggagatc  aagatgtcc  3960
aggtcctgg  aagtttact  aataaagct  gctttcccc  gccaaaaaa  aaaaaaaaa  4020
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  4058



<210> 8350
<211> 1178
<212> PRT
<213> Homo sapiens
<308> P11498
<400> 8350

Met Leu Lys Phe Arg Thr Val His Gly Gly Leu Arg Leu Leu Gly Ile 
  1               5                  10                  15
Arg Arg Thr Ser Thr Ala Pro Ala Ala Ser Pro Asn Val Arg Arg Leu 
             20                  25                  30
Glu Tyr Lys Pro Ile Lys Lys Val Met Val Ala Asn Arg Gly Glu Ile 
         35                  40                  45
Ala Ile Arg Val Phe Arg Ala Cys Thr Glu Leu Gly Ile Arg Thr Val 
     50                  55                  60
Ala Ile Tyr Ser Glu Gln Asp Thr Gly Gln Met His Arg Gln Lys Ala 
 65                  70                  75                  80
Asp Glu Ala Tyr Leu Ile Gly Arg Gly Leu Ala Pro Val Gln Ala Tyr 
                 85                  90                  95
Leu His Ile Pro Asp Ile Ile Lys Val Ala Lys Glu Asn Asn Val Asp 
             100                105                110
Ala Val His Pro Gly Tyr Gly Phe Leu Ser Glu Arg Ala Asp Phe Ala 
         115                120                125
Gln Ala Cys Gln Asp Ala Gly Val Arg Phe Ile Gly Pro Ser Pro Glu 
     130                135                140
Val Val Arg Lys Met Gly Asp Lys Val Glu Ala Arg Ala Ile Ala Ile 
 145                150                155                160
Ala Ala Gly Val Pro Val Val Pro Gly Thr Asp Ala Pro Ile Thr Ser 
                 165                170                175
Leu His Glu Ala His Glu Phe Ser Asn Thr Tyr Gly Phe Pro Ile Ile 
             180                185                190
Phe Lys Ala Ala Tyr Gly Gly Gly Gly Arg Gly Met Arg Val Val His 
         195                200                205
Ser Tyr Glu Glu Leu Glu Glu Asn Tyr Thr Arg Ala Tyr Ser Glu Ala 
     210                215                220
Leu Ala Ala Phe Gly Asn Gly Ala Leu Phe Val Glu Lys Phe Ile Glu 
 225                230                235                240
Lys Pro Arg His Ile Glu Val Gln Ile Leu Gly Asp Gln Tyr Gly Asn 
                 245                250                255
Ile Leu His Leu Tyr Glu Arg Asp Cys Ser Ile Gln Arg Arg His Gln 
             260                265                270
Lys Val Val Glu Ile Ala Pro Ala Ala His Leu Asp Pro Gln Leu Arg 
         275                280                285
Thr Arg Leu Thr Ser Asp Ser Val Lys Leu Ala Lys Gln Val Gly Tyr 
     290                295                300
Glu Asn Ala Gly Thr Val Glu Phe Leu Val Asp Arg His Gly Lys His 
 305                310                315                320
Tyr Phe Ile Glu Val Asn Ser Arg Leu Gln Val Glu His Thr Val Thr 
                 325                330                335
Glu Glu Ile Thr Asp Val Asp Leu Val His Ala Gln Ile His Val Ala 
             340                345                350
Glu Gly Arg Ser Leu Pro Asp Leu Gly Leu Arg Gln Glu Asn Ile Arg 
         355                360                365
Ile Asn Gly Cys Ala Ile Gln Cys Arg Val Thr Thr Glu Asp Pro Ala 
     370                375                380
Arg Ser Phe Gln Pro Asp Thr Gly Arg Ile Glu Val Phe Arg Ser Gly 
 385                390                395                400
Glu Gly Met Gly Ile Arg Leu Asp Asn Ala Ser Ala Phe Gln Gly Ala 
                 405                410                415
Val Ile Ser Pro His Tyr Asp Ser Leu Leu Val Lys Val Ile Ala His 
             420                425                430
Gly Lys Asp His Pro Thr Ala Ala Thr Lys Met Ser Arg Ala Leu Ala 
         435                440                445
Glu Phe Arg Val Arg Gly Val Lys Thr Asn Ile Ala Phe Leu Gln Asn 
     450                455                460
Val Leu Asn Asn Gln Gln Phe Leu Ala Gly Thr Val Asp Thr Gln Phe 
 465                470                475                480
Ile Asp Glu Asn Pro Glu Leu Phe Gln Leu Arg Pro Ala Gln Asn Arg 
                 485                490                495
Ala Gln Lys Leu Leu His Tyr Leu Gly His Val Met Val Asn Gly Pro 
             500                505                510
Thr Thr Pro Ile Pro Val Lys Ala Ser Pro Ser Pro Thr Asp Pro Val 
         515                520                525
Val Pro Ala Val Pro Ile Gly Pro Pro Pro Ala Gly Phe Arg Asp Ile 
     530                535                540
Leu Leu Arg Glu Gly Pro Glu Gly Phe Ala Arg Ala Val Arg Asn His 
 545                550                555                560
Pro Gly Leu Leu Leu Met Asp Thr Thr Phe Arg Asp Ala His Gln Ser 
                 565                570                575
Leu Leu Ala Thr Arg Val Arg Thr His Asp Leu Lys Lys Ile Ala Pro 
             580                585                590
Tyr Val Ala His Asn Phe Ser Lys Leu Phe Ser Met Glu Asn Trp Gly 
         595                600                605
Gly Ala Thr Phe Asp Val Ala Met Arg Phe Leu Tyr Glu Cys Pro Trp 
     610                615                620
Arg Arg Leu Gln Glu Leu Arg Glu Leu Ile Pro Asn Ile Pro Phe Gln 
 625                630                635                640
Met Leu Leu Arg Gly Ala Asn Ala Val Gly Tyr Thr Asn Tyr Pro Asp 
                 645                650                655
Asn Val Val Phe Lys Phe Cys Glu Val Ala Lys Glu Asn Gly Met Asp 
             660                665                670
Val Phe Arg Val Phe Asp Ser Leu Asn Tyr Leu Pro Asn Met Leu Leu 
         675                680                685
Gly Met Glu Ala Ala Gly Ser Ala Gly Gly Val Val Glu Ala Ala Ile 
     690                695                700
Ser Tyr Thr Gly Asp Val Ala Asp Pro Ser Arg Thr Lys Tyr Ser Leu 
 705                710                715                720
Gln Tyr Tyr Met Gly Leu Ala Glu Glu Leu Val Arg Ala Gly Thr His 
                 725                730                735
Ile Leu Cys Ile Lys Asp Met Ala Gly Leu Leu Lys Pro Thr Ala Cys 
             740                745                750
Thr Met Leu Val Ser Ser Leu Arg Asp Arg Phe Pro Asp Leu Pro Leu 
         755                760                765
His Ile His Thr His Asp Thr Ser Gly Ala Gly Val Ala Ala Met Leu 
     770                775                780
Ala Cys Ala Gln Ala Gly Ala Asp Val Val Asp Val Ala Ala Asp Ser 
 785                790                795                800
Met Ser Gly Met Thr Ser Gln Pro Ser Met Gly Ala Leu Val Ala Cys 
                 805                810                815
Thr Arg Gly Thr Pro Leu Asp Thr Glu Val Pro Met Glu Arg Val Phe 
             820                825                830
Asp Tyr Ser Glu Tyr Trp Glu Gly Ala Arg Gly Leu Tyr Ala Ala Phe 
         835                840                845
Asp Cys Thr Ala Thr Met Lys Ser Gly Asn Ser Asp Val Tyr Glu Asn 
     850                855                860
Glu Ile Pro Gly Gly Gln Tyr Thr Asn Leu His Phe Gln Ala His Ser 
 865                870                875                880
Met Gly Leu Gly Ser Lys Phe Lys Glu Val Lys Lys Ala Tyr Val Glu 
                 885                890                895
Ala Asn Gln Met Leu Gly Asp Leu Ile Lys Val Thr Pro Ser Ser Lys 
             900                905                910
Ile Val Gly Asp Leu Ala Gln Phe Met Val Gln Asn Gly Leu Ser Arg 
         915                920                925
Ala Glu Ala Glu Ala Gln Ala Glu Glu Leu Ser Phe Pro Arg Ser Val 
     930                935                940
Val Glu Phe Leu Gln Gly Tyr Ile Gly Val Pro His Gly Gly Phe Pro 
 945                950                955                960
Glu Pro Phe Arg Ser Lys Val Leu Lys Asp Leu Pro Arg Val Glu Gly 
                 965                970                975
Arg Pro Gly Ala Ser Leu Pro Pro Leu Asp Leu Gln Ala Leu Glu Lys 
             980                985                990
Glu Leu Val Asp Arg His Gly Glu Glu Val Thr Pro Glu Asp Val Leu 
         995                1000                1005
Ser Ala Ala Met Tyr Pro Asp Val Phe Ala His Phe Lys Asp Phe Thr 
     1010                1015                1020
Ala Thr Phe Gly Pro Leu Asp Ser Leu Asn Thr Arg Leu Phe Leu Gln 
 1025                1030                1035                1040
Gly Pro Lys Ile Ala Glu Glu Phe Glu Val Glu Leu Glu Arg Gly Lys 
                 1045                1050                1055
Thr Leu His Ile Lys Ala Leu Ala Val Ser Asp Leu Asn Arg Ala Gly 
             1060                1065                1070
Gln Arg Gln Val Phe Phe Glu Leu Asn Gly Gln Leu Arg Ser Ile Leu 
         1075                1080                1085
Val Lys Asp Thr Gln Ala Met Lys Glu Met His Phe His Pro Lys Ala 
     1090                1095                1100
Leu Lys Asp Val Lys Gly Gln Ile Gly Ala Pro Met Pro Gly Lys Val 
 1105                1110                1115                1120
Ile Asp Ile Lys Val Val Ala Gly Ala Lys Val Ala Lys Gly Gln Pro 
                 1125                1130                1135
Leu Cys Val Leu Ser Ala Met Lys Met Glu Thr Val Val Thr Ser Pro 
             1140                1145                1150
Met Glu Gly Thr Val Arg Lys Val His Val Thr Lys Asp Met Thr Leu 
         1155                1160                1165
Glu Gly Asp Asp Leu Ile Leu Glu Ile Glu 
     1170                1175



<210> 8351
<211> 2265
<212> DNA
<213> Rattus norvegicus
<308> U32575
<400> 8351

atgtgcaaa  attctgcct  cttttcgac  atgaaggag  cagacctgg  ggctgttgc  60
acagcagtc  aaagggtgg  tgggatgct  cagcgccca  accagctgg  caaagtgga  120
cagtatcgc  gaagggagg  tcggaagaa  gcctctgtg  aggccaggc  aaaggccgc  180
atccagtct  aactagatg  cgtccgcac  ggcctaagc  aactgcaca  tgcactgaa  240
gatgtcaag  atatccagc  gtcactggc  gatgtgagc  aggactgga  gcagagcat  300
aacaccatc  agagtctca  ggacgtaaa  gacgcagtg  tgcagcaca  ccagctggc  360
gcagctgtg  agaacctca  gaacatatt  tctgtgcct  agattgtga  ggagaccca  420
gatctcatc  agcaagggg  tctcctgca  gcccaccgg  agctaatgg  tctggagtg  480
tcccgggat  ggctaatgt  tgagcagta  cgcatggac  gtgggaaca  acgggacat  540
accctcatt  atggctact  cggtagcac  caggggctc  ctgacgagc  ggccaagca  600
ctgtggatg  tgctgcaaa  atcgctggt  actgtccgc  gggatccca  cttgctggt  660
tccgtggtc  ggatcattg  aagggaaga  aaaattgac  ggcggatac  tgatcgaaa  720
aagcaaact  ggtttgttc  tcctggaag  cccaaaaac  ggaaggaaa  aatgtttgc  780
gtcttggac  gaactgtga  gactagaat  gaaggcacg  aggcggaca  cagagaatc  840
gacaagatg  ggctcgtgc  ccacctgga  atcattagg  agtacgtcc  ggatgacct  900
gtcatcgcc  agaacctgc  ggtgcagtg  ttccctcct  actatgaca  ctttaagaa  960
ctcctgagc  tgtaccacc  ggccttgag  attcggatg  aggacctcg  ctcagagga  1020
cttgaggcc  acgagattg  gagcctctt  acctgggtc  taaatacct  caccagtgc  1080
gagatgatg  ggaatgtgg  gctggcccc  gaggtggac  ttaatgccc  ggaaccgct  1140
ctctcacca  acgtggtct  tgagctgct  gacacatac  tgtcaacac  cacgtccaa  1200
atcattgcc  ggcttcgga  agcactgga  acagacaag  aagactgga  caaagagac  1260
gagccggaa  cagaccagg  cggctatta  cagacgaca  ttcctgcca  tgtattcca  1320
atgtttgaa  agaatcttc  agttgctgc  caaataagt  aagatttga  aacaaaggt  1380
ttagttttg  gtcttcagc  aatgaattc  ttcctaagt  gatacaaag  ggaagccca  1440
ctttacaaa  aggagcacc  gagaaaccg  cagcaccca  actgttacg  gcagtacat  1500
gtcgccatc  tcaataact  ccagacctt  aaagaatcc  tcatcagtc  gaaaagaaa  1560
tacctaaaa  ccgaaacag  ggaaagcct  tgtcagagt  agcccagca  ggatgggat  1620
ctagatgcc  ttgctaagg  aggctgcag  agtctgcta  aggaggtct  cctggatct  1680
gagcaacat  tgaatgagc  aatgacaaa  aagtggatg  taggatcaa  tgctgtgga  1740
atcatctgt  tcaccgtag  agactactt  aatgacttc  ccaaaatta  aaagccata  1800
aaaaagagg  tgacagctg  ggcacacag  cgtgtggtg  tggaatacc  gcgggctgt  1860
atgcagaag  gtatttcct  tcggagtgc  gaagagcgc  aggagggtg  tgagaagat  1920
gtcagagag  cggaacagc  ccgcttcct  ttccggaag  tggcatctg  atttggtga  1980
gatgcagat  gacactgtg  cacaatcgt  gcagtggca  aggtcatta  gctcacgga  2040
ccgtctctg  tctacctag  agtctcaac  ctggtcagc  aatatccag  catcagaga  2100
gaccatatt  gtgcgctgc  ggcactgcg  ggagacgcc  gccgggaca  gaagcagac  2160
atcatggag  cactggagc  gggccccat  caagcgagc  ccaactatg  gcccatctt  2220
caggagatt  tggtgccca  tctgaacgt  gcaaagctc  ttaag  2265



<210> 8352
<211> 755
<212> PRT
<213> Rattus norvegicus
<308> AAA85505
<400> 8352

Met Cys Lys Asp Ser Ala Cys Phe Ser Thr Met Lys Glu Thr Asp Leu 
  1               5                  10                  15
Glu Ala Val Ala Thr Ala Val Gln Arg Val Ala Gly Met Leu Gln Arg 
             20                  25                  30
Pro Asp Gln Leu Asp Lys Val Glu Gln Tyr Arg Arg Arg Glu Ala Arg 
         35                  40                  45
Lys Lys Ala Ser Val Glu Ala Arg Leu Lys Ala Ala Ile Gln Ser Gln 
     50                  55                  60
Leu Asp Gly Val Arg Thr Gly Leu Ser Gln Leu His Asn Ala Leu Asn 
 65                  70                  75                  80
Asp Val Lys Asp Ile Gln Gln Ser Leu Ala Asp Val Ser Lys Asp Trp 
                 85                  90                  95
Arg Gln Ser Ile Asn Thr Ile Glu Ser Leu Lys Asp Val Lys Asp Ala 
             100                105                110
Val Val Gln His Ser Gln Leu Ala Ala Ala Val Glu Asn Leu Lys Asn 
         115                120                125
Ile Phe Ser Val Pro Glu Ile Val Arg Glu Thr Gln Asp Leu Ile Glu 
     130                135                140
Gln Gly Ala Leu Leu Gln Ala His Arg Lys Leu Met Asp Leu Glu Cys 
 145                150                155                160
Ser Arg Asp Gly Leu Met Cys Glu Gln Tyr Arg Met Asp Ser Gly Asn 
                 165                170                175
Lys Arg Asp Met Thr Leu Ile His Gly Tyr Phe Gly Ser Thr Gln Gly 
             180                185                190
Leu Ser Asp Glu Leu Ala Lys Gln Leu Trp Met Val Leu Gln Arg Ser 
         195                200                205
Leu Val Thr Val Arg Arg Asp Pro Thr Leu Leu Val Ser Val Val Arg 
     210                215                220
Ile Ile Glu Arg Glu Glu Lys Ile Asp Arg Arg Ile Leu Asp Arg Lys 
 225                230                235                240
Lys Gln Thr Gly Phe Val Pro Pro Gly Arg Pro Lys Asn Trp Lys Glu 
                 245                250                255
Lys Met Phe Ala Val Leu Asp Arg Thr Val Thr Thr Arg Ile Glu Gly 
             260                265                270
Thr Gln Ala Asp Thr Arg Glu Ser Asp Lys Met Trp Leu Val Arg His 
         275                280                285
Leu Glu Ile Ile Arg Lys Tyr Val Leu Asp Asp Leu Val Ile Ala Lys 
     290                295                300
Asn Leu Leu Val Gln Cys Phe Pro Pro His Tyr Asp Ile Phe Lys Asn 
 305                310                315                320
Leu Leu Ser Met Tyr His Gln Ala Leu Ser Ile Arg Met Gln Asp Leu 
                 325                330                335
Ala Ser Glu Asp Leu Glu Ala Asn Glu Ile Val Ser Leu Leu Thr Trp 
             340                345                350
Val Leu Asn Thr Tyr Thr Ser Ala Glu Met Met Gly Asn Val Glu Leu 
         355                360                365
Ala Pro Glu Val Asp Val Asn Ala Leu Glu Pro Leu Leu Ser Pro Asn 
     370                375                380
Val Val Ser Glu Leu Leu Asp Thr Tyr Met Ser Thr Leu Thr Ser Asn 
 385                390                395                400
Ile Ile Ala Trp Leu Arg Lys Ala Leu Glu Thr Asp Lys Lys Asp Trp 
                 405                410                415
Ser Lys Glu Thr Glu Pro Glu Ala Asp Gln Asp Gly Tyr Tyr Gln Thr 
             420                425                430
Thr Leu Pro Ala Ile Val Phe Gln Met Phe Glu Gln Asn Leu Gln Val 
         435                440                445
Ala Ala Gln Ile Ser Glu Asp Leu Lys Thr Lys Val Leu Val Leu Cys 
     450                455                460
Leu Gln Gln Met Asn Ser Phe Leu Ser Arg Tyr Lys Glu Glu Ala Gln 
 465                470                475                480
Leu Tyr Lys Glu Glu His Leu Arg Asn Arg Gln His Pro His Cys Tyr 
                 485                490                495
Val Gln Tyr Met Val Ala Ile Ile Asn Asn Cys Gln Thr Phe Lys Glu 
             500                505                510
Ser Ile Ile Ser Leu Lys Arg Lys Tyr Leu Lys Pro Glu Thr Glu Glu 
         515                520                525
Ser Leu Cys Gln Ser Gln Pro Ser Met Asp Gly Ile Leu Asp Ala Ile 
     530                535                540
Ala Lys Glu Gly Cys Ser Ser Leu Leu Glu Glu Val Phe Leu Asp Leu 
 545                550                555                560
Glu Gln His Leu Asn Glu Leu Met Thr Lys Lys Trp Met Leu Gly Ser 
                 565                570                575
Asn Ala Val Asp Ile Ile Cys Val Thr Val Glu Asp Tyr Phe Asn Asp 
             580                585                590
Phe Ala Lys Ile Lys Lys Pro Tyr Lys Lys Arg Met Thr Ala Glu Ala 
         595                600                605
His Arg Arg Val Val Val Glu Tyr Leu Arg Ala Val Met Gln Lys Arg 
     610                615                620
Ile Ser Phe Arg Ser Ala Glu Glu Arg Lys Glu Gly Ala Glu Lys Met 
 625                630                635                640
Val Arg Glu Ala Glu Gln Leu Arg Phe Leu Phe Arg Lys Leu Ala Ser 
                 645                650                655
Gly Phe Gly Glu Asp Ala Asp Gly His Cys Asp Thr Ile Val Ala Val 
             660                665                670
Ala Glu Val Ile Lys Leu Thr Asp Pro Ser Leu Leu Tyr Leu Glu Val 
         675                680                685
Ser Thr Leu Val Ser Lys Tyr Pro Asp Ile Arg Asp Asp His Ile Gly 
     690                695                700
Ala Leu Leu Ala Leu Arg Gly Asp Ala Ser Arg Asp Met Lys Gln Thr 
 705                710                715                720
Ile Met Glu Thr Leu Glu Gln Gly Pro Met Gln Ala Ser Pro Asn Tyr 
                 725                730                735
Val Pro Ile Phe Gln Glu Ile Val Val Pro Ser Leu Asn Val Ala Lys 
             740                745                750
Leu Leu Lys 
         755



<210> 8353
<211> 1823
<212> DNA
<213> Homo sapiens
<308> AF055006
<400> 8353

ggcttgtcc  ccacctgga  attataagg  agtacgtcc  ggatgacct  attgtcgcc  60
aaaacctga  ggttcagtg  tttcctccc  actatgaga  ctttaagaa  ctcctgaac  120
tgtaccacc  agccctgag  acgcggatg  aggacctcg  atcggaaga  ctggaagcc  180
atgagatcg  gagcctctt  acgtgggtc  taaacacct  cacaagtac  gagatgatg  240
ggaacgtgg  gctggcccc  gaagtggat  tcggcaccc  ggagccatt  ctttctcca  300
acgtggtct  tgagctgct  gacacgtac  tgtccacgc  cacttcaaa  atcatcgcc  360
ggctgcgga  agcgctgga  acagacaag  aagactggg  caaagagac  gagccagaa  420
ccgaccagg  cgggtacta  cagaccaca  tccctgcca  tgtcttcca  atgtttgaa  480
agaatcttc  agttgctgc  cagataagt  aagatttga  aacaaaggt  ctagtttta  540
gtcttcagc  gatgaattc  ttcctaagc  gatataaag  tgaagcgca  ctgtataaa  600
aagagcacc  gaggaatcg  cagcaccct  actgctacg  tcagtacat  atcgccatc  660
tcaacaact  ccagacctt  aaggaatcc  tagtcagtt  aaaaagaaa  tatttaaag  720
atgaagtgg  agagggtgt  tctccgagc  agcccagca  ggacgggat  ttagacgcc  780
tcgcgaagg  gggctgcag  ggtttgctg  aggaggtct  cctggacct  gagcaacat  840
tgaatgaat  gatgacgaa  aagtggcta  tagggtcaa  cgctgtaga  attatctgt  900
tcaccgtgg  agactattt  aacgatttt  ccaaaatta  aaagccgta  aagaagagg  960
tgacggccg  ggcgcaccg  cgcgtggtg  tggagtacc  gcgggcggt  atgcagaag  1020
gcatttcct  ccggagccc  gaggagcgc  aggagggtg  cgagaagat  gttagggag  1080
cagagcagc  gcgcttcct  ttccggaag  tggcgtccg  tttcgggga  gacgtggac  1140
gatactgcg  caccatcgt  gctgtggcc  aagtgatca  gctgacaga  ccttctctg  1200
tctacctgg  ggtctccac  ctggtcagc  agtatccag  catcaggga  gaccacatc  1260
gtgcgctgc  ggctgtgcg  ggggacgcc  gccgtgaca  gaagcagac  atcatggag  1320
ccctggagc  gggcccagc  caggccagc  ccagctacg  gcccctctt  aaggacatt  1380
tggtgccca  cctgaacgt  gccaagctg  tcaagtagc  tccgccggc  tgccctgct  1440
gcccctcca  agcctcggt  cctgccttt  gaaacgcgg  acagctgat  gctctcctt  1500
gccacacgt  ctcctttta  ctgcacggc  tgtctttag  tgccagtgt  atgcaccgg  1560
tgtgcgtcg  gtgagcgtc  cgaggccac  tgcggaggc  cctcactgt  ctgtcaaag  1620
cctgtgggt  cagggctct  ccgcacagc  tctcttggg  gcttgtttg  tgcagtggt  1680
gaaagtgtg  ggggcacag  ggacgtgca  ctccctgcc  tcctcctcc  tgggccttc  1740
ccgcacccc  tctgcttaa  tgctcggaa  cccgtcacc  aattaaagt  tctcggctt  1800
ctcagaaaa  aaaaaaaaa  aaa  1823



<210> 8354
<211> 471
<212> PRT
<213> Homo sapiens
<308> AAC09358
<400> 8354

Leu Val Arg His Leu Glu Ile Ile Arg Lys Tyr Val Leu Asp Asp Leu 
  1               5                  10                  15
Ile Val Ala Lys Asn Leu Met Val Gln Cys Phe Pro Pro His Tyr Glu 
             20                  25                  30
Ile Phe Lys Asn Leu Leu Asn Met Tyr His Gln Ala Leu Ser Thr Arg 
         35                  40                  45
Met Gln Asp Leu Ala Ser Glu Asp Leu Glu Ala Asn Glu Ile Val Ser 
     50                  55                  60
Leu Leu Thr Trp Val Leu Asn Thr Tyr Thr Ser Thr Glu Met Met Arg 
 65                  70                  75                  80
Asn Val Glu Leu Ala Pro Glu Val Asp Val Gly Thr Leu Glu Pro Leu 
                 85                  90                  95
Leu Ser Pro His Val Val Ser Glu Leu Leu Asp Thr Tyr Met Ser Thr 
             100                105                110
Leu Thr Ser Asn Ile Ile Ala Trp Leu Arg Lys Ala Leu Glu Thr Asp 
         115                120                125
Lys Lys Asp Trp Val Lys Glu Thr Glu Pro Glu Ala Asp Gln Asp Gly 
     130                135                140
Tyr Tyr Gln Thr Thr Leu Pro Ala Ile Val Phe Gln Met Phe Glu Gln 
 145                150                155                160
Asn Leu Gln Val Ala Ala Gln Ile Ser Glu Asp Leu Lys Thr Lys Val 
                 165                170                175
Leu Val Leu Cys Leu Gln Gln Met Asn Ser Phe Leu Ser Arg Tyr Lys 
             180                185                190
Asp Glu Ala Gln Leu Tyr Lys Glu Glu His Leu Arg Asn Arg Gln His 
         195                200                205
Pro His Cys Tyr Val Gln Tyr Met Ile Ala Ile Ile Asn Asn Cys Gln 
     210                215                220
Thr Phe Lys Glu Ser Ile Val Ser Leu Lys Arg Lys Tyr Leu Lys Asn 
 225                230                235                240
Glu Val Glu Glu Gly Val Ser Pro Ser Gln Pro Ser Met Asp Gly Ile 
                 245                250                255
Leu Asp Ala Ile Ala Lys Glu Gly Cys Ser Gly Leu Leu Glu Glu Val 
             260                265                270
Phe Leu Asp Leu Glu Gln His Leu Asn Glu Leu Met Thr Lys Lys Trp 
         275                280                285
Leu Leu Gly Ser Asn Ala Val Asp Ile Ile Cys Val Thr Val Glu Asp 
     290                295                300
Tyr Phe Asn Asp Phe Ala Lys Ile Lys Lys Pro Tyr Lys Lys Arg Met 
 305                310                315                320
Thr Ala Glu Ala His Arg Arg Val Val Val Glu Tyr Leu Arg Ala Val 
                 325                330                335
Met Gln Lys Arg Ile Ser Phe Arg Ser Pro Glu Glu Arg Lys Glu Gly 
             340                345                350
Ala Glu Lys Met Val Arg Glu Ala Glu Gln Leu Arg Phe Leu Phe Arg 
         355                360                365
Lys Leu Ala Ser Gly Phe Gly Glu Asp Val Asp Gly Tyr Cys Asp Thr 
     370                375                380
Ile Val Ala Val Ala Glu Val Ile Lys Leu Thr Asp Pro Ser Leu Leu 
 385                390                395                400
Tyr Leu Glu Val Ser Thr Leu Val Ser Lys Tyr Pro Asp Ile Arg Asp 
                 405                410                415
Asp His Ile Gly Ala Leu Leu Ala Val Arg Gly Asp Ala Ser Arg Asp 
             420                425                430
Met Lys Gln Thr Ile Met Glu Thr Leu Glu Gln Gly Pro Ala Gln Ala 
         435                440                445
Ser Pro Ser Tyr Val Pro Leu Phe Lys Asp Ile Val Val Pro Ser Leu 
     450                455                460
Asn Val Ala Lys Leu Leu Lys 
 465                470



<210> 8355
<211> 2265
<212> DNA
<213> Rattus norvegicus
<308> U32575
<400> 8355

atgtgcaaa  attctgcct  cttttcgac  atgaaggag  cagacctgg  ggctgttgc  60
acagcagtc  aaagggtgg  tgggatgct  cagcgccca  accagctgg  caaagtgga  120
cagtatcgc  gaagggagg  tcggaagaa  gcctctgtg  aggccaggc  aaaggccgc  180
atccagtct  aactagatg  cgtccgcac  ggcctaagc  aactgcaca  tgcactgaa  240
gatgtcaag  atatccagc  gtcactggc  gatgtgagc  aggactgga  gcagagcat  300
aacaccatc  agagtctca  ggacgtaaa  gacgcagtg  tgcagcaca  ccagctggc  360
gcagctgtg  agaacctca  gaacatatt  tctgtgcct  agattgtga  ggagaccca  420
gatctcatc  agcaagggg  tctcctgca  gcccaccgg  agctaatgg  tctggagtg  480
tcccgggat  ggctaatgt  tgagcagta  cgcatggac  gtgggaaca  acgggacat  540
accctcatt  atggctact  cggtagcac  caggggctc  ctgacgagc  ggccaagca  600
ctgtggatg  tgctgcaaa  atcgctggt  actgtccgc  gggatccca  cttgctggt  660
tccgtggtc  ggatcattg  aagggaaga  aaaattgac  ggcggatac  tgatcgaaa  720
aagcaaact  ggtttgttc  tcctggaag  cccaaaaac  ggaaggaaa  aatgtttgc  780
gtcttggac  gaactgtga  gactagaat  gaaggcacg  aggcggaca  cagagaatc  840
gacaagatg  ggctcgtgc  ccacctgga  atcattagg  agtacgtcc  ggatgacct  900
gtcatcgcc  agaacctgc  ggtgcagtg  ttccctcct  actatgaca  ctttaagaa  960
ctcctgagc  tgtaccacc  ggccttgag  attcggatg  aggacctcg  ctcagagga  1020
cttgaggcc  acgagattg  gagcctctt  acctgggtc  taaatacct  caccagtgc  1080
gagatgatg  ggaatgtgg  gctggcccc  gaggtggac  ttaatgccc  ggaaccgct  1140
ctctcacca  acgtggtct  tgagctgct  gacacatac  tgtcaacac  cacgtccaa  1200
atcattgcc  ggcttcgga  agcactgga  acagacaag  aagactgga  caaagagac  1260
gagccggaa  cagaccagg  cggctatta  cagacgaca  ttcctgcca  tgtattcca  1320
atgtttgaa  agaatcttc  agttgctgc  caaataagt  aagatttga  aacaaaggt  1380
ttagttttg  gtcttcagc  aatgaattc  ttcctaagt  gatacaaag  ggaagccca  1440
ctttacaaa  aggagcacc  gagaaaccg  cagcaccca  actgttacg  gcagtacat  1500
gtcgccatc  tcaataact  ccagacctt  aaagaatcc  tcatcagtc  gaaaagaaa  1560
tacctaaaa  ccgaaacag  ggaaagcct  tgtcagagt  agcccagca  ggatgggat  1620
ctagatgcc  ttgctaagg  aggctgcag  agtctgcta  aggaggtct  cctggatct  1680
gagcaacat  tgaatgagc  aatgacaaa  aagtggatg  taggatcaa  tgctgtgga  1740
atcatctgt  tcaccgtag  agactactt  aatgacttc  ccaaaatta  aaagccata  1800
aaaaagagg  tgacagctg  ggcacacag  cgtgtggtg  tggaatacc  gcgggctgt  1860
atgcagaag  gtatttcct  tcggagtgc  gaagagcgc  aggagggtg  tgagaagat  1920
gtcagagag  cggaacagc  ccgcttcct  ttccggaag  tggcatctg  atttggtga  1980
gatgcagat  gacactgtg  cacaatcgt  gcagtggca  aggtcatta  gctcacgga  2040
ccgtctctg  tctacctag  agtctcaac  ctggtcagc  aatatccag  catcagaga  2100
gaccatatt  gtgcgctgc  ggcactgcg  ggagacgcc  gccgggaca  gaagcagac  2160
atcatggag  cactggagc  gggccccat  caagcgagc  ccaactatg  gcccatctt  2220
caggagatt  tggtgccca  tctgaacgt  gcaaagctc  ttaag  2265



<210> 8356
<211> 755
<212> PRT
<213> Rattus norvegicus
<308> AAA85505
<400> 8356

Met Cys Lys Asp Ser Ala Cys Phe Ser Thr Met Lys Glu Thr Asp Leu 
  1               5                  10                  15
Glu Ala Val Ala Thr Ala Val Gln Arg Val Ala Gly Met Leu Gln Arg 
             20                  25                  30
Pro Asp Gln Leu Asp Lys Val Glu Gln Tyr Arg Arg Arg Glu Ala Arg 
         35                  40                  45
Lys Lys Ala Ser Val Glu Ala Arg Leu Lys Ala Ala Ile Gln Ser Gln 
     50                  55                  60
Leu Asp Gly Val Arg Thr Gly Leu Ser Gln Leu His Asn Ala Leu Asn 
 65                  70                  75                  80
Asp Val Lys Asp Ile Gln Gln Ser Leu Ala Asp Val Ser Lys Asp Trp 
                 85                  90                  95
Arg Gln Ser Ile Asn Thr Ile Glu Ser Leu Lys Asp Val Lys Asp Ala 
             100                105                110
Val Val Gln His Ser Gln Leu Ala Ala Ala Val Glu Asn Leu Lys Asn 
         115                120                125
Ile Phe Ser Val Pro Glu Ile Val Arg Glu Thr Gln Asp Leu Ile Glu 
     130                135                140
Gln Gly Ala Leu Leu Gln Ala His Arg Lys Leu Met Asp Leu Glu Cys 
 145                150                155                160
Ser Arg Asp Gly Leu Met Cys Glu Gln Tyr Arg Met Asp Ser Gly Asn 
                 165                170                175
Lys Arg Asp Met Thr Leu Ile His Gly Tyr Phe Gly Ser Thr Gln Gly 
             180                185                190
Leu Ser Asp Glu Leu Ala Lys Gln Leu Trp Met Val Leu Gln Arg Ser 
         195                200                205
Leu Val Thr Val Arg Arg Asp Pro Thr Leu Leu Val Ser Val Val Arg 
     210                215                220
Ile Ile Glu Arg Glu Glu Lys Ile Asp Arg Arg Ile Leu Asp Arg Lys 
 225                230                235                240
Lys Gln Thr Gly Phe Val Pro Pro Gly Arg Pro Lys Asn Trp Lys Glu 
                 245                250                255
Lys Met Phe Ala Val Leu Asp Arg Thr Val Thr Thr Arg Ile Glu Gly 
             260                265                270
Thr Gln Ala Asp Thr Arg Glu Ser Asp Lys Met Trp Leu Val Arg His 
         275                280                285
Leu Glu Ile Ile Arg Lys Tyr Val Leu Asp Asp Leu Val Ile Ala Lys 
     290                295                300
Asn Leu Leu Val Gln Cys Phe Pro Pro His Tyr Asp Ile Phe Lys Asn 
 305                310                315                320
Leu Leu Ser Met Tyr His Gln Ala Leu Ser Ile Arg Met Gln Asp Leu 
                 325                330                335
Ala Ser Glu Asp Leu Glu Ala Asn Glu Ile Val Ser Leu Leu Thr Trp 
             340                345                350
Val Leu Asn Thr Tyr Thr Ser Ala Glu Met Met Gly Asn Val Glu Leu 
         355                360                365
Ala Pro Glu Val Asp Val Asn Ala Leu Glu Pro Leu Leu Ser Pro Asn 
     370                375                380
Val Val Ser Glu Leu Leu Asp Thr Tyr Met Ser Thr Leu Thr Ser Asn 
 385                390                395                400
Ile Ile Ala Trp Leu Arg Lys Ala Leu Glu Thr Asp Lys Lys Asp Trp 
                 405                410                415
Ser Lys Glu Thr Glu Pro Glu Ala Asp Gln Asp Gly Tyr Tyr Gln Thr 
             420                425                430
Thr Leu Pro Ala Ile Val Phe Gln Met Phe Glu Gln Asn Leu Gln Val 
         435                440                445
Ala Ala Gln Ile Ser Glu Asp Leu Lys Thr Lys Val Leu Val Leu Cys 
     450                455                460
Leu Gln Gln Met Asn Ser Phe Leu Ser Arg Tyr Lys Glu Glu Ala Gln 
 465                470                475                480
Leu Tyr Lys Glu Glu His Leu Arg Asn Arg Gln His Pro His Cys Tyr 
                 485                490                495
Val Gln Tyr Met Val Ala Ile Ile Asn Asn Cys Gln Thr Phe Lys Glu 
             500                505                510
Ser Ile Ile Ser Leu Lys Arg Lys Tyr Leu Lys Pro Glu Thr Glu Glu 
         515                520                525
Ser Leu Cys Gln Ser Gln Pro Ser Met Asp Gly Ile Leu Asp Ala Ile 
     530                535                540
Ala Lys Glu Gly Cys Ser Ser Leu Leu Glu Glu Val Phe Leu Asp Leu 
 545                550                555                560
Glu Gln His Leu Asn Glu Leu Met Thr Lys Lys Trp Met Leu Gly Ser 
                 565                570                575
Asn Ala Val Asp Ile Ile Cys Val Thr Val Glu Asp Tyr Phe Asn Asp 
             580                585                590
Phe Ala Lys Ile Lys Lys Pro Tyr Lys Lys Arg Met Thr Ala Glu Ala 
         595                600                605
His Arg Arg Val Val Val Glu Tyr Leu Arg Ala Val Met Gln Lys Arg 
     610                615                620
Ile Ser Phe Arg Ser Ala Glu Glu Arg Lys Glu Gly Ala Glu Lys Met 
 625                630                635                640
Val Arg Glu Ala Glu Gln Leu Arg Phe Leu Phe Arg Lys Leu Ala Ser 
                 645                650                655
Gly Phe Gly Glu Asp Ala Asp Gly His Cys Asp Thr Ile Val Ala Val 
             660                665                670
Ala Glu Val Ile Lys Leu Thr Asp Pro Ser Leu Leu Tyr Leu Glu Val 
         675                680                685
Ser Thr Leu Val Ser Lys Tyr Pro Asp Ile Arg Asp Asp His Ile Gly 
     690                695                700
Ala Leu Leu Ala Leu Arg Gly Asp Ala Ser Arg Asp Met Lys Gln Thr 
 705                710                715                720
Ile Met Glu Thr Leu Glu Gln Gly Pro Met Gln Ala Ser Pro Asn Tyr 
                 725                730                735
Val Pro Ile Phe Gln Glu Ile Val Val Pro Ser Leu Asn Val Ala Lys 
             740                745                750
Leu Leu Lys 
         755



<210> 8357
<211> 1823
<212> DNA
<213> Homo sapiens
<308> AF055006
<400> 8357

ggcttgtcc  ccacctgga  attataagg  agtacgtcc  ggatgacct  attgtcgcc  60
aaaacctga  ggttcagtg  tttcctccc  actatgaga  ctttaagaa  ctcctgaac  120
tgtaccacc  agccctgag  acgcggatg  aggacctcg  atcggaaga  ctggaagcc  180
atgagatcg  gagcctctt  acgtgggtc  taaacacct  cacaagtac  gagatgatg  240
ggaacgtgg  gctggcccc  gaagtggat  tcggcaccc  ggagccatt  ctttctcca  300
acgtggtct  tgagctgct  gacacgtac  tgtccacgc  cacttcaaa  atcatcgcc  360
ggctgcgga  agcgctgga  acagacaag  aagactggg  caaagagac  gagccagaa  420
ccgaccagg  cgggtacta  cagaccaca  tccctgcca  tgtcttcca  atgtttgaa  480
agaatcttc  agttgctgc  cagataagt  aagatttga  aacaaaggt  ctagtttta  540
gtcttcagc  gatgaattc  ttcctaagc  gatataaag  tgaagcgca  ctgtataaa  600
aagagcacc  gaggaatcg  cagcaccct  actgctacg  tcagtacat  atcgccatc  660
tcaacaact  ccagacctt  aaggaatcc  tagtcagtt  aaaaagaaa  tatttaaag  720
atgaagtgg  agagggtgt  tctccgagc  agcccagca  ggacgggat  ttagacgcc  780
tcgcgaagg  gggctgcag  ggtttgctg  aggaggtct  cctggacct  gagcaacat  840
tgaatgaat  gatgacgaa  aagtggcta  tagggtcaa  cgctgtaga  attatctgt  900
tcaccgtgg  agactattt  aacgatttt  ccaaaatta  aaagccgta  aagaagagg  960
tgacggccg  ggcgcaccg  cgcgtggtg  tggagtacc  gcgggcggt  atgcagaag  1020
gcatttcct  ccggagccc  gaggagcgc  aggagggtg  cgagaagat  gttagggag  1080
cagagcagc  gcgcttcct  ttccggaag  tggcgtccg  tttcgggga  gacgtggac  1140
gatactgcg  caccatcgt  gctgtggcc  aagtgatca  gctgacaga  ccttctctg  1200
tctacctgg  ggtctccac  ctggtcagc  agtatccag  catcaggga  gaccacatc  1260
gtgcgctgc  ggctgtgcg  ggggacgcc  gccgtgaca  gaagcagac  atcatggag  1320
ccctggagc  gggcccagc  caggccagc  ccagctacg  gcccctctt  aaggacatt  1380
tggtgccca  cctgaacgt  gccaagctg  tcaagtagc  tccgccggc  tgccctgct  1440
gcccctcca  agcctcggt  cctgccttt  gaaacgcgg  acagctgat  gctctcctt  1500
gccacacgt  ctcctttta  ctgcacggc  tgtctttag  tgccagtgt  atgcaccgg  1560
tgtgcgtcg  gtgagcgtc  cgaggccac  tgcggaggc  cctcactgt  ctgtcaaag  1620
cctgtgggt  cagggctct  ccgcacagc  tctcttggg  gcttgtttg  tgcagtggt  1680
gaaagtgtg  ggggcacag  ggacgtgca  ctccctgcc  tcctcctcc  tgggccttc  1740
ccgcacccc  tctgcttaa  tgctcggaa  cccgtcacc  aattaaagt  tctcggctt  1800
ctcagaaaa  aaaaaaaaa  aaa  1823



<210> 8358
<211> 471
<212> PRT
<213> Homo sapiens
<308> AAC09358
<400> 8358

Leu Val Arg His Leu Glu Ile Ile Arg Lys Tyr Val Leu Asp Asp Leu 
  1               5                  10                  15
Ile Val Ala Lys Asn Leu Met Val Gln Cys Phe Pro Pro His Tyr Glu 
             20                  25                  30
Ile Phe Lys Asn Leu Leu Asn Met Tyr His Gln Ala Leu Ser Thr Arg 
         35                  40                  45
Met Gln Asp Leu Ala Ser Glu Asp Leu Glu Ala Asn Glu Ile Val Ser 
     50                  55                  60
Leu Leu Thr Trp Val Leu Asn Thr Tyr Thr Ser Thr Glu Met Met Arg 
 65                  70                  75                  80
Asn Val Glu Leu Ala Pro Glu Val Asp Val Gly Thr Leu Glu Pro Leu 
                 85                  90                  95
Leu Ser Pro His Val Val Ser Glu Leu Leu Asp Thr Tyr Met Ser Thr 
             100                105                110
Leu Thr Ser Asn Ile Ile Ala Trp Leu Arg Lys Ala Leu Glu Thr Asp 
         115                120                125
Lys Lys Asp Trp Val Lys Glu Thr Glu Pro Glu Ala Asp Gln Asp Gly 
     130                135                140
Tyr Tyr Gln Thr Thr Leu Pro Ala Ile Val Phe Gln Met Phe Glu Gln 
 145                150                155                160
Asn Leu Gln Val Ala Ala Gln Ile Ser Glu Asp Leu Lys Thr Lys Val 
                 165                170                175
Leu Val Leu Cys Leu Gln Gln Met Asn Ser Phe Leu Ser Arg Tyr Lys 
             180                185                190
Asp Glu Ala Gln Leu Tyr Lys Glu Glu His Leu Arg Asn Arg Gln His 
         195                200                205
Pro His Cys Tyr Val Gln Tyr Met Ile Ala Ile Ile Asn Asn Cys Gln 
     210                215                220
Thr Phe Lys Glu Ser Ile Val Ser Leu Lys Arg Lys Tyr Leu Lys Asn 
 225                230                235                240
Glu Val Glu Glu Gly Val Ser Pro Ser Gln Pro Ser Met Asp Gly Ile 
                 245                250                255
Leu Asp Ala Ile Ala Lys Glu Gly Cys Ser Gly Leu Leu Glu Glu Val 
             260                265                270
Phe Leu Asp Leu Glu Gln His Leu Asn Glu Leu Met Thr Lys Lys Trp 
         275                280                285
Leu Leu Gly Ser Asn Ala Val Asp Ile Ile Cys Val Thr Val Glu Asp 
     290                295                300
Tyr Phe Asn Asp Phe Ala Lys Ile Lys Lys Pro Tyr Lys Lys Arg Met 
 305                310                315                320
Thr Ala Glu Ala His Arg Arg Val Val Val Glu Tyr Leu Arg Ala Val 
                 325                330                335
Met Gln Lys Arg Ile Ser Phe Arg Ser Pro Glu Glu Arg Lys Glu Gly 
             340                345                350
Ala Glu Lys Met Val Arg Glu Ala Glu Gln Leu Arg Phe Leu Phe Arg 
         355                360                365
Lys Leu Ala Ser Gly Phe Gly Glu Asp Val Asp Gly Tyr Cys Asp Thr 
     370                375                380
Ile Val Ala Val Ala Glu Val Ile Lys Leu Thr Asp Pro Ser Leu Leu 
 385                390                395                400
Tyr Leu Glu Val Ser Thr Leu Val Ser Lys Tyr Pro Asp Ile Arg Asp 
                 405                410                415
Asp His Ile Gly Ala Leu Leu Ala Val Arg Gly Asp Ala Ser Arg Asp 
             420                425                430
Met Lys Gln Thr Ile Met Glu Thr Leu Glu Gln Gly Pro Ala Gln Ala 
         435                440                445
Ser Pro Ser Tyr Val Pro Leu Phe Lys Asp Ile Val Val Pro Ser Leu 
     450                455                460
Asn Val Ala Lys Leu Leu Lys 
 465                470



<210> 8359
<211> 2265
<212> DNA
<213> Rattus norvegicus
<308> U32575
<400> 8359

atgtgcaaa  attctgcct  cttttcgac  atgaaggag  cagacctgg  ggctgttgc  60
acagcagtc  aaagggtgg  tgggatgct  cagcgccca  accagctgg  caaagtgga  120
cagtatcgc  gaagggagg  tcggaagaa  gcctctgtg  aggccaggc  aaaggccgc  180
atccagtct  aactagatg  cgtccgcac  ggcctaagc  aactgcaca  tgcactgaa  240
gatgtcaag  atatccagc  gtcactggc  gatgtgagc  aggactgga  gcagagcat  300
aacaccatc  agagtctca  ggacgtaaa  gacgcagtg  tgcagcaca  ccagctggc  360
gcagctgtg  agaacctca  gaacatatt  tctgtgcct  agattgtga  ggagaccca  420
gatctcatc  agcaagggg  tctcctgca  gcccaccgg  agctaatgg  tctggagtg  480
tcccgggat  ggctaatgt  tgagcagta  cgcatggac  gtgggaaca  acgggacat  540
accctcatt  atggctact  cggtagcac  caggggctc  ctgacgagc  ggccaagca  600
ctgtggatg  tgctgcaaa  atcgctggt  actgtccgc  gggatccca  cttgctggt  660
tccgtggtc  ggatcattg  aagggaaga  aaaattgac  ggcggatac  tgatcgaaa  720
aagcaaact  ggtttgttc  tcctggaag  cccaaaaac  ggaaggaaa  aatgtttgc  780
gtcttggac  gaactgtga  gactagaat  gaaggcacg  aggcggaca  cagagaatc  840
gacaagatg  ggctcgtgc  ccacctgga  atcattagg  agtacgtcc  ggatgacct  900
gtcatcgcc  agaacctgc  ggtgcagtg  ttccctcct  actatgaca  ctttaagaa  960
ctcctgagc  tgtaccacc  ggccttgag  attcggatg  aggacctcg  ctcagagga  1020
cttgaggcc  acgagattg  gagcctctt  acctgggtc  taaatacct  caccagtgc  1080
gagatgatg  ggaatgtgg  gctggcccc  gaggtggac  ttaatgccc  ggaaccgct  1140
ctctcacca  acgtggtct  tgagctgct  gacacatac  tgtcaacac  cacgtccaa  1200
atcattgcc  ggcttcgga  agcactgga  acagacaag  aagactgga  caaagagac  1260
gagccggaa  cagaccagg  cggctatta  cagacgaca  ttcctgcca  tgtattcca  1320
atgtttgaa  agaatcttc  agttgctgc  caaataagt  aagatttga  aacaaaggt  1380
ttagttttg  gtcttcagc  aatgaattc  ttcctaagt  gatacaaag  ggaagccca  1440
ctttacaaa  aggagcacc  gagaaaccg  cagcaccca  actgttacg  gcagtacat  1500
gtcgccatc  tcaataact  ccagacctt  aaagaatcc  tcatcagtc  gaaaagaaa  1560
tacctaaaa  ccgaaacag  ggaaagcct  tgtcagagt  agcccagca  ggatgggat  1620
ctagatgcc  ttgctaagg  aggctgcag  agtctgcta  aggaggtct  cctggatct  1680
gagcaacat  tgaatgagc  aatgacaaa  aagtggatg  taggatcaa  tgctgtgga  1740
atcatctgt  tcaccgtag  agactactt  aatgacttc  ccaaaatta  aaagccata  1800
aaaaagagg  tgacagctg  ggcacacag  cgtgtggtg  tggaatacc  gcgggctgt  1860
atgcagaag  gtatttcct  tcggagtgc  gaagagcgc  aggagggtg  tgagaagat  1920
gtcagagag  cggaacagc  ccgcttcct  ttccggaag  tggcatctg  atttggtga  1980
gatgcagat  gacactgtg  cacaatcgt  gcagtggca  aggtcatta  gctcacgga  2040
ccgtctctg  tctacctag  agtctcaac  ctggtcagc  aatatccag  catcagaga  2100
gaccatatt  gtgcgctgc  ggcactgcg  ggagacgcc  gccgggaca  gaagcagac  2160
atcatggag  cactggagc  gggccccat  caagcgagc  ccaactatg  gcccatctt  2220
caggagatt  tggtgccca  tctgaacgt  gcaaagctc  ttaag  2265



<210> 8360
<211> 755
<212> PRT
<213> Rattus norvegicus
<308> AAA85505
<400> 8360

Met Cys Lys Asp Ser Ala Cys Phe Ser Thr Met Lys Glu Thr Asp Leu 
  1               5                  10                  15
Glu Ala Val Ala Thr Ala Val Gln Arg Val Ala Gly Met Leu Gln Arg 
             20                  25                  30
Pro Asp Gln Leu Asp Lys Val Glu Gln Tyr Arg Arg Arg Glu Ala Arg 
         35                  40                  45
Lys Lys Ala Ser Val Glu Ala Arg Leu Lys Ala Ala Ile Gln Ser Gln 
     50                  55                  60
Leu Asp Gly Val Arg Thr Gly Leu Ser Gln Leu His Asn Ala Leu Asn 
 65                  70                  75                  80
Asp Val Lys Asp Ile Gln Gln Ser Leu Ala Asp Val Ser Lys Asp Trp 
                 85                  90                  95
Arg Gln Ser Ile Asn Thr Ile Glu Ser Leu Lys Asp Val Lys Asp Ala 
             100                105                110
Val Val Gln His Ser Gln Leu Ala Ala Ala Val Glu Asn Leu Lys Asn 
         115                120                125
Ile Phe Ser Val Pro Glu Ile Val Arg Glu Thr Gln Asp Leu Ile Glu 
     130                135                140
Gln Gly Ala Leu Leu Gln Ala His Arg Lys Leu Met Asp Leu Glu Cys 
 145                150                155                160
Ser Arg Asp Gly Leu Met Cys Glu Gln Tyr Arg Met Asp Ser Gly Asn 
                 165                170                175
Lys Arg Asp Met Thr Leu Ile His Gly Tyr Phe Gly Ser Thr Gln Gly 
             180                185                190
Leu Ser Asp Glu Leu Ala Lys Gln Leu Trp Met Val Leu Gln Arg Ser 
         195                200                205
Leu Val Thr Val Arg Arg Asp Pro Thr Leu Leu Val Ser Val Val Arg 
     210                215                220
Ile Ile Glu Arg Glu Glu Lys Ile Asp Arg Arg Ile Leu Asp Arg Lys 
 225                230                235                240
Lys Gln Thr Gly Phe Val Pro Pro Gly Arg Pro Lys Asn Trp Lys Glu 
                 245                250                255
Lys Met Phe Ala Val Leu Asp Arg Thr Val Thr Thr Arg Ile Glu Gly 
             260                265                270
Thr Gln Ala Asp Thr Arg Glu Ser Asp Lys Met Trp Leu Val Arg His 
         275                280                285
Leu Glu Ile Ile Arg Lys Tyr Val Leu Asp Asp Leu Val Ile Ala Lys 
     290                295                300
Asn Leu Leu Val Gln Cys Phe Pro Pro His Tyr Asp Ile Phe Lys Asn 
 305                310                315                320
Leu Leu Ser Met Tyr His Gln Ala Leu Ser Ile Arg Met Gln Asp Leu 
                 325                330                335
Ala Ser Glu Asp Leu Glu Ala Asn Glu Ile Val Ser Leu Leu Thr Trp 
             340                345                350
Val Leu Asn Thr Tyr Thr Ser Ala Glu Met Met Gly Asn Val Glu Leu 
         355                360                365
Ala Pro Glu Val Asp Val Asn Ala Leu Glu Pro Leu Leu Ser Pro Asn 
     370                375                380
Val Val Ser Glu Leu Leu Asp Thr Tyr Met Ser Thr Leu Thr Ser Asn 
 385                390                395                400
Ile Ile Ala Trp Leu Arg Lys Ala Leu Glu Thr Asp Lys Lys Asp Trp 
                 405                410                415
Ser Lys Glu Thr Glu Pro Glu Ala Asp Gln Asp Gly Tyr Tyr Gln Thr 
             420                425                430
Thr Leu Pro Ala Ile Val Phe Gln Met Phe Glu Gln Asn Leu Gln Val 
         435                440                445
Ala Ala Gln Ile Ser Glu Asp Leu Lys Thr Lys Val Leu Val Leu Cys 
     450                455                460
Leu Gln Gln Met Asn Ser Phe Leu Ser Arg Tyr Lys Glu Glu Ala Gln 
 465                470                475                480
Leu Tyr Lys Glu Glu His Leu Arg Asn Arg Gln His Pro His Cys Tyr 
                 485                490                495
Val Gln Tyr Met Val Ala Ile Ile Asn Asn Cys Gln Thr Phe Lys Glu 
             500                505                510
Ser Ile Ile Ser Leu Lys Arg Lys Tyr Leu Lys Pro Glu Thr Glu Glu 
         515                520                525
Ser Leu Cys Gln Ser Gln Pro Ser Met Asp Gly Ile Leu Asp Ala Ile 
     530                535                540
Ala Lys Glu Gly Cys Ser Ser Leu Leu Glu Glu Val Phe Leu Asp Leu 
 545                550                555                560
Glu Gln His Leu Asn Glu Leu Met Thr Lys Lys Trp Met Leu Gly Ser 
                 565                570                575
Asn Ala Val Asp Ile Ile Cys Val Thr Val Glu Asp Tyr Phe Asn Asp 
             580                585                590
Phe Ala Lys Ile Lys Lys Pro Tyr Lys Lys Arg Met Thr Ala Glu Ala 
         595                600                605
His Arg Arg Val Val Val Glu Tyr Leu Arg Ala Val Met Gln Lys Arg 
     610                615                620
Ile Ser Phe Arg Ser Ala Glu Glu Arg Lys Glu Gly Ala Glu Lys Met 
 625                630                635                640
Val Arg Glu Ala Glu Gln Leu Arg Phe Leu Phe Arg Lys Leu Ala Ser 
                 645                650                655
Gly Phe Gly Glu Asp Ala Asp Gly His Cys Asp Thr Ile Val Ala Val 
             660                665                670
Ala Glu Val Ile Lys Leu Thr Asp Pro Ser Leu Leu Tyr Leu Glu Val 
         675                680                685
Ser Thr Leu Val Ser Lys Tyr Pro Asp Ile Arg Asp Asp His Ile Gly 
     690                695                700
Ala Leu Leu Ala Leu Arg Gly Asp Ala Ser Arg Asp Met Lys Gln Thr 
 705                710                715                720
Ile Met Glu Thr Leu Glu Gln Gly Pro Met Gln Ala Ser Pro Asn Tyr 
                 725                730                735
Val Pro Ile Phe Gln Glu Ile Val Val Pro Ser Leu Asn Val Ala Lys 
             740                745                750
Leu Leu Lys 
         755



<210> 8361
<211> 1823
<212> DNA
<213> Homo sapiens
<308> AF055006
<400> 8361

ggcttgtcc  ccacctgga  attataagg  agtacgtcc  ggatgacct  attgtcgcc  60
aaaacctga  ggttcagtg  tttcctccc  actatgaga  ctttaagaa  ctcctgaac  120
tgtaccacc  agccctgag  acgcggatg  aggacctcg  atcggaaga  ctggaagcc  180
atgagatcg  gagcctctt  acgtgggtc  taaacacct  cacaagtac  gagatgatg  240
ggaacgtgg  gctggcccc  gaagtggat  tcggcaccc  ggagccatt  ctttctcca  300
acgtggtct  tgagctgct  gacacgtac  tgtccacgc  cacttcaaa  atcatcgcc  360
ggctgcgga  agcgctgga  acagacaag  aagactggg  caaagagac  gagccagaa  420
ccgaccagg  cgggtacta  cagaccaca  tccctgcca  tgtcttcca  atgtttgaa  480
agaatcttc  agttgctgc  cagataagt  aagatttga  aacaaaggt  ctagtttta  540
gtcttcagc  gatgaattc  ttcctaagc  gatataaag  tgaagcgca  ctgtataaa  600
aagagcacc  gaggaatcg  cagcaccct  actgctacg  tcagtacat  atcgccatc  660
tcaacaact  ccagacctt  aaggaatcc  tagtcagtt  aaaaagaaa  tatttaaag  720
atgaagtgg  agagggtgt  tctccgagc  agcccagca  ggacgggat  ttagacgcc  780
tcgcgaagg  gggctgcag  ggtttgctg  aggaggtct  cctggacct  gagcaacat  840
tgaatgaat  gatgacgaa  aagtggcta  tagggtcaa  cgctgtaga  attatctgt  900
tcaccgtgg  agactattt  aacgatttt  ccaaaatta  aaagccgta  aagaagagg  960
tgacggccg  ggcgcaccg  cgcgtggtg  tggagtacc  gcgggcggt  atgcagaag  1020
gcatttcct  ccggagccc  gaggagcgc  aggagggtg  cgagaagat  gttagggag  1080
cagagcagc  gcgcttcct  ttccggaag  tggcgtccg  tttcgggga  gacgtggac  1140
gatactgcg  caccatcgt  gctgtggcc  aagtgatca  gctgacaga  ccttctctg  1200
tctacctgg  ggtctccac  ctggtcagc  agtatccag  catcaggga  gaccacatc  1260
gtgcgctgc  ggctgtgcg  ggggacgcc  gccgtgaca  gaagcagac  atcatggag  1320
ccctggagc  gggcccagc  caggccagc  ccagctacg  gcccctctt  aaggacatt  1380
tggtgccca  cctgaacgt  gccaagctg  tcaagtagc  tccgccggc  tgccctgct  1440
gcccctcca  agcctcggt  cctgccttt  gaaacgcgg  acagctgat  gctctcctt  1500
gccacacgt  ctcctttta  ctgcacggc  tgtctttag  tgccagtgt  atgcaccgg  1560
tgtgcgtcg  gtgagcgtc  cgaggccac  tgcggaggc  cctcactgt  ctgtcaaag  1620
cctgtgggt  cagggctct  ccgcacagc  tctcttggg  gcttgtttg  tgcagtggt  1680
gaaagtgtg  ggggcacag  ggacgtgca  ctccctgcc  tcctcctcc  tgggccttc  1740
ccgcacccc  tctgcttaa  tgctcggaa  cccgtcacc  aattaaagt  tctcggctt  1800
ctcagaaaa  aaaaaaaaa  aaa  1823



<210> 8362
<211> 471
<212> PRT
<213> Homo sapiens
<308> AAC09358
<400> 8362

Leu Val Arg His Leu Glu Ile Ile Arg Lys Tyr Val Leu Asp Asp Leu 
  1               5                  10                  15
Ile Val Ala Lys Asn Leu Met Val Gln Cys Phe Pro Pro His Tyr Glu 
             20                  25                  30
Ile Phe Lys Asn Leu Leu Asn Met Tyr His Gln Ala Leu Ser Thr Arg 
         35                  40                  45
Met Gln Asp Leu Ala Ser Glu Asp Leu Glu Ala Asn Glu Ile Val Ser 
     50                  55                  60
Leu Leu Thr Trp Val Leu Asn Thr Tyr Thr Ser Thr Glu Met Met Arg 
 65                  70                  75                  80
Asn Val Glu Leu Ala Pro Glu Val Asp Val Gly Thr Leu Glu Pro Leu 
                 85                  90                  95
Leu Ser Pro His Val Val Ser Glu Leu Leu Asp Thr Tyr Met Ser Thr 
             100                105                110
Leu Thr Ser Asn Ile Ile Ala Trp Leu Arg Lys Ala Leu Glu Thr Asp 
         115                120                125
Lys Lys Asp Trp Val Lys Glu Thr Glu Pro Glu Ala Asp Gln Asp Gly 
     130                135                140
Tyr Tyr Gln Thr Thr Leu Pro Ala Ile Val Phe Gln Met Phe Glu Gln 
 145                150                155                160
Asn Leu Gln Val Ala Ala Gln Ile Ser Glu Asp Leu Lys Thr Lys Val 
                 165                170                175
Leu Val Leu Cys Leu Gln Gln Met Asn Ser Phe Leu Ser Arg Tyr Lys 
             180                185                190
Asp Glu Ala Gln Leu Tyr Lys Glu Glu His Leu Arg Asn Arg Gln His 
         195                200                205
Pro His Cys Tyr Val Gln Tyr Met Ile Ala Ile Ile Asn Asn Cys Gln 
     210                215                220
Thr Phe Lys Glu Ser Ile Val Ser Leu Lys Arg Lys Tyr Leu Lys Asn 
 225                230                235                240
Glu Val Glu Glu Gly Val Ser Pro Ser Gln Pro Ser Met Asp Gly Ile 
                 245                250                255
Leu Asp Ala Ile Ala Lys Glu Gly Cys Ser Gly Leu Leu Glu Glu Val 
             260                265                270
Phe Leu Asp Leu Glu Gln His Leu Asn Glu Leu Met Thr Lys Lys Trp 
         275                280                285
Leu Leu Gly Ser Asn Ala Val Asp Ile Ile Cys Val Thr Val Glu Asp 
     290                295                300
Tyr Phe Asn Asp Phe Ala Lys Ile Lys Lys Pro Tyr Lys Lys Arg Met 
 305                310                315                320
Thr Ala Glu Ala His Arg Arg Val Val Val Glu Tyr Leu Arg Ala Val 
                 325                330                335
Met Gln Lys Arg Ile Ser Phe Arg Ser Pro Glu Glu Arg Lys Glu Gly 
             340                345                350
Ala Glu Lys Met Val Arg Glu Ala Glu Gln Leu Arg Phe Leu Phe Arg 
         355                360                365
Lys Leu Ala Ser Gly Phe Gly Glu Asp Val Asp Gly Tyr Cys Asp Thr 
     370                375                380
Ile Val Ala Val Ala Glu Val Ile Lys Leu Thr Asp Pro Ser Leu Leu 
 385                390                395                400
Tyr Leu Glu Val Ser Thr Leu Val Ser Lys Tyr Pro Asp Ile Arg Asp 
                 405                410                415
Asp His Ile Gly Ala Leu Leu Ala Val Arg Gly Asp Ala Ser Arg Asp 
             420                425                430
Met Lys Gln Thr Ile Met Glu Thr Leu Glu Gln Gly Pro Ala Gln Ala 
         435                440                445
Ser Pro Ser Tyr Val Pro Leu Phe Lys Asp Ile Val Val Pro Ser Leu 
     450                455                460
Asn Val Ala Lys Leu Leu Lys 
 465                470



<210> 8363
<211> 2265
<212> DNA
<213> Rattus norvegicus
<308> U32575
<400> 8363

atgtgcaaa  attctgcct  cttttcgac  atgaaggag  cagacctgg  ggctgttgc  60
acagcagtc  aaagggtgg  tgggatgct  cagcgccca  accagctgg  caaagtgga  120
cagtatcgc  gaagggagg  tcggaagaa  gcctctgtg  aggccaggc  aaaggccgc  180
atccagtct  aactagatg  cgtccgcac  ggcctaagc  aactgcaca  tgcactgaa  240
gatgtcaag  atatccagc  gtcactggc  gatgtgagc  aggactgga  gcagagcat  300
aacaccatc  agagtctca  ggacgtaaa  gacgcagtg  tgcagcaca  ccagctggc  360
gcagctgtg  agaacctca  gaacatatt  tctgtgcct  agattgtga  ggagaccca  420
gatctcatc  agcaagggg  tctcctgca  gcccaccgg  agctaatgg  tctggagtg  480
tcccgggat  ggctaatgt  tgagcagta  cgcatggac  gtgggaaca  acgggacat  540
accctcatt  atggctact  cggtagcac  caggggctc  ctgacgagc  ggccaagca  600
ctgtggatg  tgctgcaaa  atcgctggt  actgtccgc  gggatccca  cttgctggt  660
tccgtggtc  ggatcattg  aagggaaga  aaaattgac  ggcggatac  tgatcgaaa  720
aagcaaact  ggtttgttc  tcctggaag  cccaaaaac  ggaaggaaa  aatgtttgc  780
gtcttggac  gaactgtga  gactagaat  gaaggcacg  aggcggaca  cagagaatc  840
gacaagatg  ggctcgtgc  ccacctgga  atcattagg  agtacgtcc  ggatgacct  900
gtcatcgcc  agaacctgc  ggtgcagtg  ttccctcct  actatgaca  ctttaagaa  960
ctcctgagc  tgtaccacc  ggccttgag  attcggatg  aggacctcg  ctcagagga  1020
cttgaggcc  acgagattg  gagcctctt  acctgggtc  taaatacct  caccagtgc  1080
gagatgatg  ggaatgtgg  gctggcccc  gaggtggac  ttaatgccc  ggaaccgct  1140
ctctcacca  acgtggtct  tgagctgct  gacacatac  tgtcaacac  cacgtccaa  1200
atcattgcc  ggcttcgga  agcactgga  acagacaag  aagactgga  caaagagac  1260
gagccggaa  cagaccagg  cggctatta  cagacgaca  ttcctgcca  tgtattcca  1320
atgtttgaa  agaatcttc  agttgctgc  caaataagt  aagatttga  aacaaaggt  1380
ttagttttg  gtcttcagc  aatgaattc  ttcctaagt  gatacaaag  ggaagccca  1440
ctttacaaa  aggagcacc  gagaaaccg  cagcaccca  actgttacg  gcagtacat  1500
gtcgccatc  tcaataact  ccagacctt  aaagaatcc  tcatcagtc  gaaaagaaa  1560
tacctaaaa  ccgaaacag  ggaaagcct  tgtcagagt  agcccagca  ggatgggat  1620
ctagatgcc  ttgctaagg  aggctgcag  agtctgcta  aggaggtct  cctggatct  1680
gagcaacat  tgaatgagc  aatgacaaa  aagtggatg  taggatcaa  tgctgtgga  1740
atcatctgt  tcaccgtag  agactactt  aatgacttc  ccaaaatta  aaagccata  1800
aaaaagagg  tgacagctg  ggcacacag  cgtgtggtg  tggaatacc  gcgggctgt  1860
atgcagaag  gtatttcct  tcggagtgc  gaagagcgc  aggagggtg  tgagaagat  1920
gtcagagag  cggaacagc  ccgcttcct  ttccggaag  tggcatctg  atttggtga  1980
gatgcagat  gacactgtg  cacaatcgt  gcagtggca  aggtcatta  gctcacgga  2040
ccgtctctg  tctacctag  agtctcaac  ctggtcagc  aatatccag  catcagaga  2100
gaccatatt  gtgcgctgc  ggcactgcg  ggagacgcc  gccgggaca  gaagcagac  2160
atcatggag  cactggagc  gggccccat  caagcgagc  ccaactatg  gcccatctt  2220
caggagatt  tggtgccca  tctgaacgt  gcaaagctc  ttaag  2265



<210> 8364
<211> 755
<212> PRT
<213> Rattus norvegicus
<308> AAA85505
<400> 8364

Met Cys Lys Asp Ser Ala Cys Phe Ser Thr Met Lys Glu Thr Asp Leu 
  1               5                  10                  15
Glu Ala Val Ala Thr Ala Val Gln Arg Val Ala Gly Met Leu Gln Arg 
             20                  25                  30
Pro Asp Gln Leu Asp Lys Val Glu Gln Tyr Arg Arg Arg Glu Ala Arg 
         35                  40                  45
Lys Lys Ala Ser Val Glu Ala Arg Leu Lys Ala Ala Ile Gln Ser Gln 
     50                  55                  60
Leu Asp Gly Val Arg Thr Gly Leu Ser Gln Leu His Asn Ala Leu Asn 
 65                  70                  75                  80
Asp Val Lys Asp Ile Gln Gln Ser Leu Ala Asp Val Ser Lys Asp Trp 
                 85                  90                  95
Arg Gln Ser Ile Asn Thr Ile Glu Ser Leu Lys Asp Val Lys Asp Ala 
             100                105                110
Val Val Gln His Ser Gln Leu Ala Ala Ala Val Glu Asn Leu Lys Asn 
         115                120                125
Ile Phe Ser Val Pro Glu Ile Val Arg Glu Thr Gln Asp Leu Ile Glu 
     130                135                140
Gln Gly Ala Leu Leu Gln Ala His Arg Lys Leu Met Asp Leu Glu Cys 
 145                150                155                160
Ser Arg Asp Gly Leu Met Cys Glu Gln Tyr Arg Met Asp Ser Gly Asn 
                 165                170                175
Lys Arg Asp Met Thr Leu Ile His Gly Tyr Phe Gly Ser Thr Gln Gly 
             180                185                190
Leu Ser Asp Glu Leu Ala Lys Gln Leu Trp Met Val Leu Gln Arg Ser 
         195                200                205
Leu Val Thr Val Arg Arg Asp Pro Thr Leu Leu Val Ser Val Val Arg 
     210                215                220
Ile Ile Glu Arg Glu Glu Lys Ile Asp Arg Arg Ile Leu Asp Arg Lys 
 225                230                235                240
Lys Gln Thr Gly Phe Val Pro Pro Gly Arg Pro Lys Asn Trp Lys Glu 
                 245                250                255
Lys Met Phe Ala Val Leu Asp Arg Thr Val Thr Thr Arg Ile Glu Gly 
             260                265                270
Thr Gln Ala Asp Thr Arg Glu Ser Asp Lys Met Trp Leu Val Arg His 
         275                280                285
Leu Glu Ile Ile Arg Lys Tyr Val Leu Asp Asp Leu Val Ile Ala Lys 
     290                295                300
Asn Leu Leu Val Gln Cys Phe Pro Pro His Tyr Asp Ile Phe Lys Asn 
 305                310                315                320
Leu Leu Ser Met Tyr His Gln Ala Leu Ser Ile Arg Met Gln Asp Leu 
                 325                330                335
Ala Ser Glu Asp Leu Glu Ala Asn Glu Ile Val Ser Leu Leu Thr Trp 
             340                345                350
Val Leu Asn Thr Tyr Thr Ser Ala Glu Met Met Gly Asn Val Glu Leu 
         355                360                365
Ala Pro Glu Val Asp Val Asn Ala Leu Glu Pro Leu Leu Ser Pro Asn 
     370                375                380
Val Val Ser Glu Leu Leu Asp Thr Tyr Met Ser Thr Leu Thr Ser Asn 
 385                390                395                400
Ile Ile Ala Trp Leu Arg Lys Ala Leu Glu Thr Asp Lys Lys Asp Trp 
                 405                410                415
Ser Lys Glu Thr Glu Pro Glu Ala Asp Gln Asp Gly Tyr Tyr Gln Thr 
             420                425                430
Thr Leu Pro Ala Ile Val Phe Gln Met Phe Glu Gln Asn Leu Gln Val 
         435                440                445
Ala Ala Gln Ile Ser Glu Asp Leu Lys Thr Lys Val Leu Val Leu Cys 
     450                455                460
Leu Gln Gln Met Asn Ser Phe Leu Ser Arg Tyr Lys Glu Glu Ala Gln 
 465                470                475                480
Leu Tyr Lys Glu Glu His Leu Arg Asn Arg Gln His Pro His Cys Tyr 
                 485                490                495
Val Gln Tyr Met Val Ala Ile Ile Asn Asn Cys Gln Thr Phe Lys Glu 
             500                505                510
Ser Ile Ile Ser Leu Lys Arg Lys Tyr Leu Lys Pro Glu Thr Glu Glu 
         515                520                525
Ser Leu Cys Gln Ser Gln Pro Ser Met Asp Gly Ile Leu Asp Ala Ile 
     530                535                540
Ala Lys Glu Gly Cys Ser Ser Leu Leu Glu Glu Val Phe Leu Asp Leu 
 545                550                555                560
Glu Gln His Leu Asn Glu Leu Met Thr Lys Lys Trp Met Leu Gly Ser 
                 565                570                575
Asn Ala Val Asp Ile Ile Cys Val Thr Val Glu Asp Tyr Phe Asn Asp 
             580                585                590
Phe Ala Lys Ile Lys Lys Pro Tyr Lys Lys Arg Met Thr Ala Glu Ala 
         595                600                605
His Arg Arg Val Val Val Glu Tyr Leu Arg Ala Val Met Gln Lys Arg 
     610                615                620
Ile Ser Phe Arg Ser Ala Glu Glu Arg Lys Glu Gly Ala Glu Lys Met 
 625                630                635                640
Val Arg Glu Ala Glu Gln Leu Arg Phe Leu Phe Arg Lys Leu Ala Ser 
                 645                650                655
Gly Phe Gly Glu Asp Ala Asp Gly His Cys Asp Thr Ile Val Ala Val 
             660                665                670
Ala Glu Val Ile Lys Leu Thr Asp Pro Ser Leu Leu Tyr Leu Glu Val 
         675                680                685
Ser Thr Leu Val Ser Lys Tyr Pro Asp Ile Arg Asp Asp His Ile Gly 
     690                695                700
Ala Leu Leu Ala Leu Arg Gly Asp Ala Ser Arg Asp Met Lys Gln Thr 
 705                710                715                720
Ile Met Glu Thr Leu Glu Gln Gly Pro Met Gln Ala Ser Pro Asn Tyr 
                 725                730                735
Val Pro Ile Phe Gln Glu Ile Val Val Pro Ser Leu Asn Val Ala Lys 
             740                745                750
Leu Leu Lys 
         755



<210> 8365
<211> 1823
<212> DNA
<213> Homo sapiens
<308> AF055006
<400> 8365

ggcttgtcc  ccacctgga  attataagg  agtacgtcc  ggatgacct  attgtcgcc  60
aaaacctga  ggttcagtg  tttcctccc  actatgaga  ctttaagaa  ctcctgaac  120
tgtaccacc  agccctgag  acgcggatg  aggacctcg  atcggaaga  ctggaagcc  180
atgagatcg  gagcctctt  acgtgggtc  taaacacct  cacaagtac  gagatgatg  240
ggaacgtgg  gctggcccc  gaagtggat  tcggcaccc  ggagccatt  ctttctcca  300
acgtggtct  tgagctgct  gacacgtac  tgtccacgc  cacttcaaa  atcatcgcc  360
ggctgcgga  agcgctgga  acagacaag  aagactggg  caaagagac  gagccagaa  420
ccgaccagg  cgggtacta  cagaccaca  tccctgcca  tgtcttcca  atgtttgaa  480
agaatcttc  agttgctgc  cagataagt  aagatttga  aacaaaggt  ctagtttta  540
gtcttcagc  gatgaattc  ttcctaagc  gatataaag  tgaagcgca  ctgtataaa  600
aagagcacc  gaggaatcg  cagcaccct  actgctacg  tcagtacat  atcgccatc  660
tcaacaact  ccagacctt  aaggaatcc  tagtcagtt  aaaaagaaa  tatttaaag  720
atgaagtgg  agagggtgt  tctccgagc  agcccagca  ggacgggat  ttagacgcc  780
tcgcgaagg  gggctgcag  ggtttgctg  aggaggtct  cctggacct  gagcaacat  840
tgaatgaat  gatgacgaa  aagtggcta  tagggtcaa  cgctgtaga  attatctgt  900
tcaccgtgg  agactattt  aacgatttt  ccaaaatta  aaagccgta  aagaagagg  960
tgacggccg  ggcgcaccg  cgcgtggtg  tggagtacc  gcgggcggt  atgcagaag  1020
gcatttcct  ccggagccc  gaggagcgc  aggagggtg  cgagaagat  gttagggag  1080
cagagcagc  gcgcttcct  ttccggaag  tggcgtccg  tttcgggga  gacgtggac  1140
gatactgcg  caccatcgt  gctgtggcc  aagtgatca  gctgacaga  ccttctctg  1200
tctacctgg  ggtctccac  ctggtcagc  agtatccag  catcaggga  gaccacatc  1260
gtgcgctgc  ggctgtgcg  ggggacgcc  gccgtgaca  gaagcagac  atcatggag  1320
ccctggagc  gggcccagc  caggccagc  ccagctacg  gcccctctt  aaggacatt  1380
tggtgccca  cctgaacgt  gccaagctg  tcaagtagc  tccgccggc  tgccctgct  1440
gcccctcca  agcctcggt  cctgccttt  gaaacgcgg  acagctgat  gctctcctt  1500
gccacacgt  ctcctttta  ctgcacggc  tgtctttag  tgccagtgt  atgcaccgg  1560
tgtgcgtcg  gtgagcgtc  cgaggccac  tgcggaggc  cctcactgt  ctgtcaaag  1620
cctgtgggt  cagggctct  ccgcacagc  tctcttggg  gcttgtttg  tgcagtggt  1680
gaaagtgtg  ggggcacag  ggacgtgca  ctccctgcc  tcctcctcc  tgggccttc  1740
ccgcacccc  tctgcttaa  tgctcggaa  cccgtcacc  aattaaagt  tctcggctt  1800
ctcagaaaa  aaaaaaaaa  aaa  1823



<210> 8366
<211> 471
<212> PRT
<213> Homo sapiens
<308> AAC09358
<400> 8366

Leu Val Arg His Leu Glu Ile Ile Arg Lys Tyr Val Leu Asp Asp Leu 
  1               5                  10                  15
Ile Val Ala Lys Asn Leu Met Val Gln Cys Phe Pro Pro His Tyr Glu 
             20                  25                  30
Ile Phe Lys Asn Leu Leu Asn Met Tyr His Gln Ala Leu Ser Thr Arg 
         35                  40                  45
Met Gln Asp Leu Ala Ser Glu Asp Leu Glu Ala Asn Glu Ile Val Ser 
     50                  55                  60
Leu Leu Thr Trp Val Leu Asn Thr Tyr Thr Ser Thr Glu Met Met Arg 
 65                  70                  75                  80
Asn Val Glu Leu Ala Pro Glu Val Asp Val Gly Thr Leu Glu Pro Leu 
                 85                  90                  95
Leu Ser Pro His Val Val Ser Glu Leu Leu Asp Thr Tyr Met Ser Thr 
             100                105                110
Leu Thr Ser Asn Ile Ile Ala Trp Leu Arg Lys Ala Leu Glu Thr Asp 
         115                120                125
Lys Lys Asp Trp Val Lys Glu Thr Glu Pro Glu Ala Asp Gln Asp Gly 
     130                135                140
Tyr Tyr Gln Thr Thr Leu Pro Ala Ile Val Phe Gln Met Phe Glu Gln 
 145                150                155                160
Asn Leu Gln Val Ala Ala Gln Ile Ser Glu Asp Leu Lys Thr Lys Val 
                 165                170                175
Leu Val Leu Cys Leu Gln Gln Met Asn Ser Phe Leu Ser Arg Tyr Lys 
             180                185                190
Asp Glu Ala Gln Leu Tyr Lys Glu Glu His Leu Arg Asn Arg Gln His 
         195                200                205
Pro His Cys Tyr Val Gln Tyr Met Ile Ala Ile Ile Asn Asn Cys Gln 
     210                215                220
Thr Phe Lys Glu Ser Ile Val Ser Leu Lys Arg Lys Tyr Leu Lys Asn 
 225                230                235                240
Glu Val Glu Glu Gly Val Ser Pro Ser Gln Pro Ser Met Asp Gly Ile 
                 245                250                255
Leu Asp Ala Ile Ala Lys Glu Gly Cys Ser Gly Leu Leu Glu Glu Val 
             260                265                270
Phe Leu Asp Leu Glu Gln His Leu Asn Glu Leu Met Thr Lys Lys Trp 
         275                280                285
Leu Leu Gly Ser Asn Ala Val Asp Ile Ile Cys Val Thr Val Glu Asp 
     290                295                300
Tyr Phe Asn Asp Phe Ala Lys Ile Lys Lys Pro Tyr Lys Lys Arg Met 
 305                310                315                320
Thr Ala Glu Ala His Arg Arg Val Val Val Glu Tyr Leu Arg Ala Val 
                 325                330                335
Met Gln Lys Arg Ile Ser Phe Arg Ser Pro Glu Glu Arg Lys Glu Gly 
             340                345                350
Ala Glu Lys Met Val Arg Glu Ala Glu Gln Leu Arg Phe Leu Phe Arg 
         355                360                365
Lys Leu Ala Ser Gly Phe Gly Glu Asp Val Asp Gly Tyr Cys Asp Thr 
     370                375                380
Ile Val Ala Val Ala Glu Val Ile Lys Leu Thr Asp Pro Ser Leu Leu 
 385                390                395                400
Tyr Leu Glu Val Ser Thr Leu Val Ser Lys Tyr Pro Asp Ile Arg Asp 
                 405                410                415
Asp His Ile Gly Ala Leu Leu Ala Val Arg Gly Asp Ala Ser Arg Asp 
             420                425                430
Met Lys Gln Thr Ile Met Glu Thr Leu Glu Gln Gly Pro Ala Gln Ala 
         435                440                445
Ser Pro Ser Tyr Val Pro Leu Phe Lys Asp Ile Val Val Pro Ser Leu 
     450                455                460
Asn Val Ala Lys Leu Leu Lys 
 465                470



<210> 8367
<211> 2368
<212> DNA
<213> Rattus norvegicus
<308> U32577
<400> 8367

tcggcacga  acgcggaga  aatggcggc  ggggtcgaa  cggcggccg  agtggcagc  60
acagagccc  aaatggagg  agagagcgg  gcgccctgc  tgccgagcg  caacggagc  120
ccggtcccg  agggtgaag  acgacctac  cagaatgag  agaggaagg  gaaaaacat  180
aaaagagga  gcaatcgct  tgagccata  gcaaaccca  ctaaaagat  cagagcctt  240
attacaaat  taccttttg  tgtgaaatg  cagtcactt  aagacctgg  taaagaaaa  300
gttggtgag  taacatacg  ggagctctt  atggacgct  aaggaaagt  aaggggatg  360
gctgttgtt  agttcaaga  ggaggagag  atgaaaaaa  ctgccgaag  tctaaacaa  420
catagtctg  gtggaaggc  actgaaagt  aaagaagat  ctgatggtg  acatgcaag  480
agagcaatg  aaaaggctg  aagacttgg  agcacagta  ttgtagcaa  tctggatta  540
aaagttggc  ggaagaaac  gaaagaagt  tttagtatg  ctggtgtgg  ggtccgagc  600
gacattctg  aagataaag  tgggaaaag  cgtggaata  gcactgtga  ttttgaaca  660
tccattgaa  ctgtgcaag  tatatctat  tttaatggc  agttgctgt  tgatagacc  720
atgcacgtc  agatggatg  gagggcttt  ccaaaggga  acttttttc  tcctgaacg  780
ccacagcaa  ttcctcatg  acttggtgg  atcggtatg  ggttaggac  tggagggca  840
cctattgat  ccaaccacc  gaacaaagg  attggaatg  gaaacctag  acctgcagg  900
atgggaatg  aaggcatag  atttggaat  aataaaatc  gaggcatgg  aggaccctt  960
ggtggtggt  tggaaaaca  ggggcgatt  ggatccggg  tgaacatgg  ccggataaa  1020
gaaatccta  gtaatgcac  gaagagggg  gagatcatt  caaagcaag  aggaagtgg  1080
gctggaggc  gtgtccctg  gatcgaaag  atgggccct  gcattgacc  cattagcgg  1140
gctggcatg  agcgcatgg  cgcaggctt  ggccatggc  tggatcgag  gggctctga  1200
attgagcgt  tgggcctgg  catggaccg  atgggctca  ttgagcgca  gggctccgg  1260
atcgagcgc  tgggcccac  aggccttga  cacatggcc  ccagtattg  gcgcatggg  1320
cagaccatg  aacgcattg  ttctggtgt  gagcgcatg  gtgccggta  gggcttcgg  1380
ctggagcgc  tggccgcac  cattgaccg  gtgggccaa  ccattgagc  catgggctc  1440
ggtgtagag  gcatgggtc  tgccattga  cgaatgggc  taagcatgg  tcgaatggt  1500
cccacaggc  tgggggccg  cctggagcg  atgggtcct  tgatggatc  tatggccac  1560
ggcctggag  gcatgggcg  caacaacct  gagcgcatg  gccttgagc  catgggagc  1620
aacagtctt  agcgcatgg  cctggaacg  atgggcgcc  acagcctgg  acggatggg  1680
cctgccatg  gcccagcat  gggcgctgg  attgagcga  tgggcctgg  catgggtgg  1740
gccggcggt  ctagttttg  ccgaaccat  gagatggag  ggggcaact  tggaggaag  1800
ttcgcaggt  cctttggcg  agctggagg  catgcccct  gagtagcca  gaaggcctg  1860
cagatattt  tgagaaatc  cccatttga  tttacatgg  agatgctaa  ggacaaatt  1920
aatgaatgt  gccacgtgc  gtacgccga  atcaagatg  agaacggaa  gtccaaggg  1980
tgcggtgtg  ttaagtttg  gtctccaga  gtggctgag  gagcctgcc  gatgatgaa  2040
ggcatgaag  tgagtggcc  agagattga  gttcgaatt  atagaaacg  ttaagcagt  2100
gcctttttt  aacatcagt  ccagacctc  gaatttgta  tttttcttg  taaccattt  2160
aatttgttg  ctggatgta  aaagatgtt  aaaaaattc  gttgctttt  ggggtaatt  2220
gaattaatt  tttaatgat  ggggttcca  ttgactgtt  gcattgaga  tgcaatgtg  2280
gcaattttt  ttgtagttg  ggcatcttg  tgacatcga  tatgacttt  ataataaat  2340
ccagttcct  aaaaaaaaa  aaaaaaaa  2368



<210> 8368
<211> 697
<212> PRT
<213> Rattus norvegicus
<308> AAA83442
<400> 8368

Ser Ala Arg Asp Ala Glu Lys Met Ala Ala Gly Val Glu Ala Ala Ala 
  1               5                  10                  15
Glu Val Ala Ala Thr Glu Pro Lys Met Glu Glu Glu Ser Gly Ala Pro 
             20                  25                  30
Cys Val Pro Ser Gly Asn Gly Ala Pro Val Pro Lys Gly Glu Glu Arg 
         35                  40                  45
Pro Thr Gln Asn Glu Lys Arg Lys Glu Lys Asn Ile Lys Arg Gly Gly 
     50                  55                  60
Asn Arg Phe Glu Pro Tyr Ala Asn Pro Thr Lys Arg Tyr Arg Ala Phe 
 65                  70                  75                  80
Ile Thr Asn Ile Pro Phe Asp Val Lys Trp Gln Ser Leu Lys Asp Leu 
                 85                  90                  95
Val Lys Glu Lys Val Gly Glu Val Thr Tyr Val Glu Leu Leu Met Asp 
             100                105                110
Ala Glu Gly Lys Ser Arg Gly Cys Ala Val Val Glu Phe Lys Met Glu 
         115                120                125
Glu Ser Met Lys Lys Ala Ala Glu Val Leu Asn Lys His Ser Leu Ser 
     130                135                140
Gly Arg Pro Leu Lys Val Lys Glu Asp Pro Asp Gly Glu His Ala Arg 
 145                150                155                160
Arg Ala Met Gln Lys Ala Gly Arg Leu Gly Ser Thr Val Phe Val Ala 
                 165                170                175
Asn Leu Asp Tyr Lys Val Gly Trp Lys Lys Leu Lys Glu Val Phe Ser 
             180                185                190
Met Ala Gly Val Val Val Arg Ala Asp Ile Leu Glu Asp Lys Asp Gly 
         195                200                205
Lys Ser Arg Gly Ile Gly Thr Val Thr Phe Glu Gln Ser Ile Glu Ala 
     210                215                220
Val Gln Ala Ile Ser Met Phe Asn Gly Gln Leu Leu Phe Asp Arg Pro 
 225                230                235                240
Met His Val Lys Met Asp Glu Arg Ala Leu Pro Lys Gly Asp Phe Phe 
                 245                250                255
Pro Pro Glu Arg Pro Gln Gln Leu Pro His Gly Leu Gly Gly Ile Gly 
             260                265                270
Met Gly Leu Gly Pro Gly Gly Gln Pro Ile Asp Ala Asn His Leu Asn 
         275                280                285
Lys Gly Ile Gly Met Gly Asn Leu Gly Pro Ala Gly Met Gly Met Glu 
     290                295                300
Gly Ile Gly Phe Gly Ile Asn Lys Ile Gly Gly Met Glu Gly Pro Phe 
 305                310                315                320
Gly Gly Gly Met Glu Asn Met Gly Arg Phe Gly Ser Gly Met Asn Met 
                 325                330                335
Gly Arg Ile Asn Glu Ile Leu Ser Asn Ala Leu Lys Arg Gly Glu Ile 
             340                345                350
Ile Ala Lys Gln Gly Gly Ser Gly Ala Gly Gly Ser Val Pro Gly Ile 
         355                360                365
Glu Arg Met Gly Pro Gly Ile Asp Arg Ile Ser Gly Ala Gly Met Glu 
     370                375                380
Arg Met Gly Ala Gly Leu Gly His Gly Met Asp Arg Val Gly Ser Glu 
 385                390                395                400
Ile Glu Arg Met Gly Leu Val Met Asp Arg Met Gly Ser Val Glu Arg 
                 405                410                415
Met Gly Ser Gly Ile Glu Arg Met Gly Pro Leu Gly Leu Asp His Met 
             420                425                430
Ala Ser Ser Ile Glu Arg Met Gly Gln Thr Met Glu Arg Ile Gly Ser 
         435                440                445
Gly Val Glu Arg Met Gly Ala Gly Met Gly Phe Gly Leu Glu Arg Met 
     450                455                460
Ala Ala Pro Ile Asp Arg Val Gly Gln Thr Ile Glu Arg Met Gly Ser 
 465                470                475                480
Gly Val Glu Arg Met Gly Pro Ala Ile Glu Arg Met Gly Leu Ser Met 
                 485                490                495
Asp Arg Met Val Pro Thr Gly Met Gly Ala Gly Leu Glu Arg Met Gly 
             500                505                510
Pro Val Met Asp Arg Met Ala Thr Gly Leu Glu Arg Met Gly Ala Asn 
         515                520                525
Asn Leu Glu Arg Met Gly Leu Glu Arg Met Gly Ala Asn Ser Leu Glu 
     530                535                540
Arg Met Gly Leu Glu Arg Met Gly Ala Asn Ser Leu Glu Arg Met Gly 
 545                550                555                560
Pro Ala Met Gly Pro Ala Leu Gly Ala Gly Ile Glu Arg Met Gly Leu 
                 565                570                575
Ala Met Gly Gly Ala Gly Gly Ala Ser Phe Asp Arg Thr Ile Glu Met 
             580                585                590
Glu Arg Gly Asn Phe Gly Gly Ser Phe Ala Gly Ser Phe Gly Gly Ala 
         595                600                605
Gly Gly His Ala Pro Gly Val Ala Arg Lys Ala Cys Gln Ile Phe Val 
     610                615                620
Arg Asn Leu Pro Phe Asp Phe Thr Trp Lys Met Leu Lys Asp Lys Phe 
 625                630                635                640
Asn Glu Cys Gly His Val Leu Tyr Ala Asp Ile Lys Met Glu Asn Gly 
                 645                650                655
Lys Ser Lys Gly Cys Gly Val Val Lys Phe Glu Ser Pro Glu Val Ala 
             660                665                670
Glu Arg Ala Cys Arg Met Met Asn Gly Met Lys Leu Ser Gly Arg Glu 
         675                680                685
Ile Asp Val Arg Ile Asp Arg Asn Ala 
     690                695



<210> 8369
<211> 4088
<212> DNA
<213> Homo sapiens
<308> AK024911
<400> 8369

tttttggta  tctgtttgg  tgcccaatt  ggataactg  ggaccaata  cagcattgt  60
tctttgtta  cagaggaat  ggctgtgtg  gaattatgc  tggaatttt  gcggtggta  120
aattaatgt  aaacgtgtg  tcttgtcta  aaaatgtta  tcttggttg  ttgctgaat  180
tgaaagttg  gtgaaccaa  gattccgaa  agttgcctt  gtgccagta  attgtaaac  240
aaatattaa  aacctgaat  ttcaaaatt  gcctagttt  aagagaaca  aaactattt  300
ctgtcgtgc  atagaatgg  ttagaataa  caaaaggat  agcttaact  acggaaggg  360
tggatttag  aggaatatg  taaggactc  attgagtac  gagggaagc  gatctaaag  420
tggtgtgat  tcttggaga  cctgaattt  ggtctgctt  ttaaatgtc  gcagctcta  480
tgcaatgct  gtaacgcgt  ggagaagga  atattaagg  gcccagctt  taacaagga  540
ggcgaggcg  ggcacttct  tcagcttcc  cttagaagg  ttcatttta  aagactaac  600
ttgtgacat  agtcatatt  ttagtttgt  tataactgt  attggtatt  actattttt  660
tcttttctt  ttccccttc  ttgctcttc  gactggtct  tggcttcct  caaagggat  720
tgcgtaagt  tcgtctagt  acttattgg  atttgagcc  tctaacttg  aggactggt  780
tcactcgac  cgtttcctt  tgactctat  gtgttgttg  attcaagat  gaagagagc  840
tgaaaaaag  tgcggaagt  ctaaacaag  atagtctga  cggaagacc  ctgaaagtc  900
aagaagtaa  ctcttgctt  acactgcgg  tactgtgtg  aattgttga  tgatcctac  960
ttggaatta  ggaaagacg  tcatggtcc  agacggcat  tacaaagca  gtgccagcc  1020
gttgtttct  atgaagagt  tcggtcata  cctacagca  ccattccct  caaggactt  1080
ggggtggtg  ccaagcaga  cctgagtgg  tgctgacca  cttctaata  ctgtgattt  1140
tctgaggcc  tgttgtctc  gggactctc  aaccatgag  ccgtgggtt  gtgccatta  1200
gttttactc  atctgaccc  tcttcttgg  ccatctttt  ttctttttt  aaaaagtga  1260
tttgttcca  cctgggcaa  atggtgaaa  cccctctct  caaaaggta  aaaaattag  1320
caggcatgg  ggcgcatgc  tgtagtcct  gctacttgg  aggctgagg  aggaggatc  1380
tttgagccc  ggatgtgga  gttgcagtg  gctgagatt  caccattgc  ctccagccc  1440
ggcaacagt  agaccctgt  taaaaaata  aaaataaag  gagtttgtt  ttcctcaaa  1500
ctgctttca  atctcatct  aatcaaata  attccttga  gaagaaggt  tttttgttg  1560
ttaaatccc  cttggctgg  cgcagtggc  cacgcctgt  atccccggc  ctttgggag  1620
ctgaggtgg  tggatcaag  tcatgagtt  aagaccagc  tgaccaaca  ggtgaaacc  1680
tgtctacta  aaatacaaa  aattagctg  gcgtagtgg  gggtgcctg  aatccatct  1740
ctcgggagg  tgaggcagg  gaatcgctg  aacccagga  gcggaggtt  cagtgagcc  1800
agatcgcgc  attgaactc  agcctgggc  gtaagagca  agctctgtc  caaaaaaac  1860
tccctctta  cttcttttc  cctcttctc  tggggagga  gatgagtag  ttcagagtg  1920
agcttggta  ggtctaagg  ctctcatgt  ttatgatgt  ttttttagt  ctgatggtg  1980
taattgaca  gacagagag  tgaagaaga  agtcagtac  gagcttcac  gaccttccc  2040
gatgttgtt  tactgcgca  ccctcacac  cacgcctcc  acacctgaa  gacttgaag  2100
atgggggcg  ttgtgtggt  tagaactgt  tctcaaact  ctggaagcc  ttgacgggg  2160
ttgcagaag  tacaaaacc  cattgatga  ttagtaaga  tcagctata  caagcccat  2220
atgctctaa  ttcagtctg  cggttctac  ttatatcag  taatcatgt  tccctccct  2280
ccctgcttt  cttttttac  tagtgcaat  gagagctgt  tttttagtg  tacacttca  2340
gccttttct  cctttccta  ttctttagc  ggactcttc  aagctggta  ttgagttca  2400
ttgactttc  tgttaatag  tttgagaga  gctttccaa  caacctttc  gtttctaag  2460
cttgagaat  tcatttact  tgcgagcat  gtttgcgtt  tactgggtc  gttaaacgt  2520
acacctttt  tgcttgttt  aggatcctg  tggtgaaca  gccaggaga  caatgcaaa  2580
ggtgatggc  acgactggt  ggatgggta  gggaccagg  ggcccagga  tgattacta  2640
cccacccag  atcctaaat  atcccaaca  cccaaatga  attatccat  cattacagg  2700
tggaagact  ggaagcaca  tatttgtag  aaatgtaag  aaacagaac  atcgtctaa  2760
gtagaaaat  agaacttta  gaaatgacc  tgtcaatat  ttataaaag  aattctcac  2820
tttgagaag  aaaatgtaa  gaagggttt  gttcttgat  tctttaaaa  tcagcctta  2880
aggcgggct  tgtctgcat  cctaagtca  aggcttgac  gtggtctcg  tggggctgt  2940
attcctgag  ttcgcaggt  tttccacaa  cagtaaccg  gtctgcatt  tccgttggt  3000
tattttatg  agttttggt  cagagtaag  ctgtacgag  agaagtgca  tgacacctt  3060
ctcttgttg  gtctggggt  aatgataat  cctccacca  ctgcaaggg  aaatattta  3120
aataaagta  gttgggtgg  gtggggagt  gtaaagctt  tcagggaaa  aatttttta  3180
aaatgttca  aaaatgagt  ttaatttga  gtatgaggt  acttaagtt  ctgagaaaa  3240
agacaatat  tttactata  gtacagttt  tttacagtg  aggccaggc  ttataatcc  3300
attttaaaa  ttccattgc  gttgattag  ttttgtgac  ttatttcct  atacttttt  3360
ccaaccaaa  catgtatca  tcatgtagt  aaaatgttg  gtttcttaa  atgtttaca  3420
tgaggtttt  accccgttc  ctctcgatt  gctggatta  aaagttggc  ggaagaaac  3480
gaaggaagt  tttagtatg  ctggtgtgg  ggtccgagc  gacattctt  aagataaag  3540
tggaaaaag  cgtggaata  gcactgtta  ttttgaaca  tccattgaa  ctgtgcaag  3600
tatatgtat  cttctgcag  aattcaact  atgaacagt  tgacctaaa  tgctgtgtt  3660
gtaatgtag  tttgtgtga  gaagaggtg  ctgtgtgta  tcatgtttt  tatgtgact  3720
gggggagtg  attactgtg  aattaagag  ttctctggg  cggaccggt  acggtggct  3780
acgcctgta  tcccagcac  tcgggaggc  aaggcgggc  gatcacttg  ggtcagttc  3840
agaccagcc  ggccaacat  gtgaaaccc  ggctctact  aaaaatgca  aaattagct  3900
ggcgcagtg  tgggtgcct  taatcccag  tactcggga  gctgaggca  aagaatcgc  3960
tgaacccgg  aggtggagg  tgcagtgag  cgagattgc  ccactgcac  ccaccagcc  4020
gggtgatag  gtgagactc  gtctcaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  4080
aaaaaaaa  4088



<210> 8370
<211> 730
<212> PRT
<213> Homo sapiens
<308> P52272
<400> 8370

Met Ala Ala Gly Val Glu Ala Ala Ala Glu Val Ala Ala Thr Glu Ile 
  1               5                  10                  15
Lys Met Glu Glu Glu Ser Gly Ala Pro Gly Val Pro Ser Gly Asn Gly 
             20                  25                  30
Ala Pro Gly Pro Lys Gly Glu Gly Glu Arg Pro Ala Gln Asn Glu Lys 
         35                  40                  45
Arg Lys Val Lys Asn Ile Lys Arg Gly Gly Asn Arg Phe Glu Pro Tyr 
     50                  55                  60
Ala Asn Pro Thr Lys Arg Tyr Arg Ala Phe Ile Thr Asn Ile Pro Phe 
 65                  70                  75                  80
Asp Val Lys Trp Gln Ser Leu Lys Asp Leu Val Lys Glu Lys Val Gly 
                 85                  90                  95
Glu Val Thr Tyr Val Glu Leu Leu Met Asp Ala Glu Gly Lys Ser Arg 
             100                105                110
Gly Cys Ala Val Val Glu Phe Lys Met Glu Glu Ser Met Lys Lys Ala 
         115                120                125
Ala Glu Val Leu Asn Lys His Ser Leu Ser Gly Arg Pro Leu Lys Val 
     130                135                140
Lys Glu Asp Pro Asp Gly Glu His Ala Arg Arg Ala Met Gln Lys Val 
 145                150                155                160
Met Ala Thr Thr Gly Gly Met Gly Met Gly Pro Gly Gly Pro Gly Met 
                 165                170                175
Ile Thr Ile Pro Pro Ser Ile Leu Asn Asn Pro Asn Ile Pro Asn Glu 
             180                185                190
Ile Ile His Ala Leu Gln Ala Gly Arg Leu Gly Ser Thr Val Phe Val 
         195                200                205
Ala Asn Leu Asp Tyr Lys Val Gly Trp Lys Lys Leu Lys Glu Val Phe 
     210                215                220
Ser Met Ala Gly Val Val Val Arg Ala Asp Ile Leu Glu Asp Lys Asp 
 225                230                235                240
Gly Lys Ser Arg Gly Ile Gly Thr Val Thr Phe Glu Gln Ser Ile Glu 
                 245                250                255
Ala Val Gln Ala Ile Ser Met Phe Asn Gly Gln Leu Leu Phe Asp Arg 
             260                265                270
Pro Met His Val Lys Met Asp Glu Arg Ala Leu Pro Lys Gly Asp Phe 
         275                280                285
Phe Pro Pro Glu Arg Pro Gln Gln Leu Pro His Gly Leu Gly Gly Ile 
     290                295                300
Gly Met Gly Leu Gly Pro Gly Gly Gln Pro Ile Asp Ala Asn His Leu 
 305                310                315                320
Asn Lys Gly Ile Gly Met Gly Asn Ile Gly Pro Ala Gly Met Gly Met 
                 325                330                335
Glu Gly Ile Gly Phe Gly Ile Asn Lys Met Gly Gly Met Glu Gly Pro 
             340                345                350
Phe Gly Gly Gly Met Glu Asn Met Gly Arg Phe Gly Ser Gly Met Asn 
         355                360                365
Met Gly Arg Ile Asn Glu Ile Leu Ser Asn Ala Leu Lys Arg Gly Glu 
     370                375                380
Ile Ile Ala Lys Gln Gly Gly Gly Gly Gly Gly Gly Ser Val Pro Gly 
 385                390                395                400
Ile Glu Arg Met Gly Pro Gly Ile Asp Arg Leu Gly Gly Ala Gly Met 
                 405                410                415
Glu Arg Met Gly Ala Gly Leu Gly His Gly Met Asp Arg Val Gly Ser 
             420                425                430
Glu Ile Glu Arg Met Gly Leu Val Met Asp Arg Met Gly Ser Val Glu 
         435                440                445
Arg Met Gly Ser Gly Ile Glu Arg Met Gly Pro Leu Gly Leu Asp His 
     450                455                460
Met Ala Ser Ser Ile Glu Arg Met Gly Gln Thr Met Glu Arg Ile Gly 
 465                470                475                480
Ser Gly Val Glu Arg Met Gly Ala Gly Met Gly Phe Gly Leu Glu Arg 
                 485                490                495
Met Ala Ala Pro Ile Asp Arg Val Gly Gln Thr Ile Glu Arg Met Gly 
             500                505                510
Ser Gly Val Glu Arg Met Gly Pro Ala Ile Glu Arg Met Gly Pro Ser 
         515                520                525
Met Glu Arg Met Val Pro Ala Gly Met Gly Ala Gly Leu Glu Arg Met 
     530                535                540
Gly Pro Val Met Asp Arg Met Ala Thr Gly Leu Glu Arg Met Gly Ala 
 545                550                555                560
Asn Asn Leu Glu Arg Met Gly Leu Glu Arg Met Gly Ala Asn Ser Leu 
                 565                570                575
Glu Arg Met Gly Leu Glu Arg Met Gly Ala Asn Ser Leu Glu Arg Met 
             580                585                590
Gly Pro Ala Met Gly Pro Ala Leu Gly Ala Gly Ile Glu Arg Met Gly 
         595                600                605
Leu Ala Met Gly Gly Gly Gly Gly Ala Ser Phe Asp Arg Ala Ile Glu 
     610                615                620
Met Glu Arg Gly Asn Phe Gly Gly Ser Phe Ala Gly Ser Phe Gly Gly 
 625                630                635                640
Ala Gly Gly His Ala Pro Gly Val Ala Arg Lys Ala Cys Gln Ile Phe 
                 645                650                655
Val Arg Asn Leu Pro Phe Asp Phe Thr Trp Lys Met Leu Lys Asp Lys 
             660                665                670
Phe Asn Glu Cys Gly His Val Leu Tyr Ala Asp Ile Lys Met Glu Asn 
         675                680                685
Gly Lys Ser Lys Gly Cys Gly Val Val Lys Phe Glu Ser Pro Glu Val 
     690                695                700
Ala Glu Arg Ala Cys Arg Met Met Asn Gly Met Lys Leu Ser Gly Arg 
 705                710                715                720
Glu Ile Asp Val Arg Ile Asp Arg Asn Ala 
                 725                730



<210> 8371
<211> 4344
<212> DNA
<213> Rattus norvegicus
<308> U32681
<400> 8371

ggaacagat  ctggtttgg  tgtgaggct  gtgaatgga  gagacaggt  tcggggtcg  60
gtggagatc  tttaccagg  ttcctgggg  accatgtgt  atgacagct  ggacatcaa  120
gatgccaac  tggtgtgca  gcagctggg  tgtggctgg  ccttgtctg  cccaggaag  180
gcccagttt  gacagggtc  gggtcccat  gttctggat  acgtggcct  tagaggaca  240
gaggcctat  tgtggagct  ctcccaccg  ggctggctc  ctcataact  tggacatca  300
gaggatgct  gagtgatct  ctcagattc  caaacaagc  gtcccacac  cggttggtg  360
aaccccggg  gcacaaata  cgatgtgat  tacgacact  aagaaacca  agaaacttc  420
caaacaagc  gtcccacac  tgattggtg  aaccatggg  gcacaatta  tgatgtgat  480
tatgacact  aagaaacca  agaaggaac  gattctggt  tggctgtga  gctggtgaa  540
ggaggagac  ggtgtcggg  tcgtgtgga  atcctttac  agggttcct  gggcaccgt  600
tgtgacgac  gctgggaca  caatgatgc  aacgtggtg  gcaggcagc  gggctgtgg  660
tgggccttg  ctgccccag  aagtgccca  tttggacag  gctctgggt  cattgttct  720
gatgacgtg  cctgtagag  acatgaggc  tatctgtgg  gctgctccc  ccgaggctg  780
ctctctcat  actgtggac  tcaggagga  gctggagtc  tctgttcat  ttctcaaac  840
agcagtccc  cacccgatt  tcaaacaag  agtcccaca  ccggttggt  gaaccccgg  900
ggcacaaat  acgatgtgt  ctatggacc  gaacagacc  cagacgcaa  agattctgg  960
ttggctgtg  ggctggtga  tggaggaga  aggtgtcag  gtcgtgtgg  gatccttta  1020
cagggttcc  ggggtaccg  gtgtgacga  agctgggac  ccaaggatg  caacgtggt  1080
tgcaggcag  tggtctgtg  ctgggcctt  tctgcccca  gaagtgccc  ctttggaca  1140
ggctctgga  ccattgttc  ggatgacgt  gcctgtaca  gacatgagg  ctatctgtg  1200
agctgctcc  accgaggct  gctctctca  aactgtggc  accatgagg  tgctggagt  1260
atctgttca  atgcccaaa  ccagagcac  acctggcca  atatgtggc  tactaccac  1320
ccagaaact  caacagatt  gtggactac  aaatattct  cctctgttc  tacaacaca  1380
ttccccacc  tagccgatt  gtggacaac  ccttctccg  aatacacct  tggaggttt  1440
ctgacccta  cctatgggc  gttttccag  ccatactac  ctggaagct  tcctaacaa  1500
gccagatgt  tgtggaaaa  tttcgtctc  agcatgaac  gtgtgacag  ggtcttcac  1560
gatgtgcag  ttgaaggag  ttgcaacta  gactacatc  tggtttttg  tggccctga  1620
aacaattct  ctctcattg  tcgggtttg  gatgggttc  atggatctt  cacctcaac  1680
cagaacttc  tgtctgtag  ctttatcac  gatggcagt  tcacgagga  agggttcca  1740
gctgactac  actccactc  tatcagcac  agcacaacc  ctccaacga  gttcccgat  1800
gttactgat  ggtggacaa  tccttctcc  gaatacacc  gtggaggtt  actgaccct  1860
ccctatggg  agttttcca  cccatacta  cctggaagc  atcctaaca  tgccagatg  1920
ttgtggaaa  ttttcgtcc  cagcatgaa  cgtgtgaca  tggtcttca  agatgtgca  1980
cttgaagga  gttgcaact  tgactacat  ctgggtttt  atggtcctg  atacaattc  2040
tctctcatt  ctcgggttt  tgatgggtc  aatggatct  tcacctcaa  ccagaactt  2100
atgtctgta  tctttatca  ggatggcag  gtcacgagg  gagggttcc  agctgacta  2160
tactccact  ctatcagga  cagcacaac  cctccaacg  cgttcccga  cattactgg  2220
aatgattct  cattggtgc  gaggctggt  aatggaaca  accggtgtg  gggccgagt  2280
gagatcttg  acagaggct  ttgggtacc  tgtgccgac  acagctggg  catcaatga  2340
gccaatgtg  tctgcagac  gctcggttg  ggctctgct  tgtctgctc  aggaaatgc  2400
tggtttggt  agggttcag  gctcattgt  ctggatgat  tgtcttgct  tgggtatga  2460
tcccacctg  ggaattgtc  tcaccctgg  tggcttgtt  ataattgtc  tcatgttga  2520
gatgcagga  tcatttgct  actccctga  ccgactccc  ctcctggtc  agtttggac  2580
agtcctcct  ttgtaaact  tacttgtgg  ggtttcctg  ctggactct  tgggcaatt  2640
tctagccca  actaccctg  gagctatcc  aataatgcc  gatgtttgt  gaacattga  2700
gtcccaaac  actaccgcg  gactgtggt  ttcagagat  tgcagctgg  agggggctg  2760
aactatgac  atatagaga  ttttgatgg  ccccaccac  gttcacctc  cattgcccg  2820
gtttgtgat  gggccatgg  ctctttcac  tcaacatcc  acttcatgt  agttcgctt  2880
accactgat  acagtgtta  tcgaagagg  ttccgggct  actactact  agactttga  2940
aataatacc  ccaatctcc  ttgtctgtc  aatcacatg  gagccagtg  gagcaggag  3000
taccttcag  ccatgggct  ctcctccag  gatcttgtc  ttcctggtt  gaacgtgag  3060
taccagtgt  agcctcaga  aacacaaag  gaggtcata  tcacaattc  ctacacagg  3120
tgcggtact  ccaaacagg  tgacaacga  accatcaac  actccaact  cctcaaagc  3180
gctgtttca  atggcatca  caaaaggag  aaggatctc  acatccatg  cagctgcaa  3240
atgcttcag  acacctggg  caacaccat  tacatcacc  acaacacag  cgagatcca  3300
gaagtccag  atggcaatt  tgacgtgaa  atttccttt  atacatcct  ctccttctt  3360
tatccagtg  ccagcagcc  atattatgt  gatctggac  agaatttgt  ccttcaggc  3420
gaagtcctc  attcggata  ctctttggc  ctgtttgtg  acacctgtg  ggcttcgcc  3480
catcccaat  acttctcgt  tttgacata  gatctcatc  ggagtggat  catacgaga  3540
gaaacttac  aatcttact  ctcgccctc  ccacgcatc  cccgcttta  attcagttc  3600
ttccacttc  tgaaccgct  cccctcagt  tacctacag  gtaaactgg  ggtttgtcg  3660
gcaaacgat  tctcctcac  gtgctacag  ggatgtgta  taaggtcca  gagggatgt  3720
ggctcctac  aagaaaagg  ggatgttgt  ctgggaccc  tccagttgc  atctcccag  3780
aaagaaaag  ggagtctcg  cttggcagt  gcagatgtg  agaagccag  cagctccca  3840
gaggtctat  ccactgcag  catctttgg  ggagtcttc  tggccctgg  tgtagctgt  3900
gcagccttc  cactgggaa  gaagacacg  actgcccgt  gtcaacctc  aagtactaa  3960
atgtgaagc  aaacaaccc  gacattggt  ccaaatgca  agattccca  aaaagatgg  4020
agtcaggag  gtctaatgc  tggcaccca  atacacgat  actaggctt  ccttagcac  4080
aatgtgtgg  cgagtatga  cagatggta  agaagaaag  tgggggcca  gttttccca  4140
ggtctagag  ctgaaggct  ggaagaatg  cataggaga  tgagatcag  gtctacaat  4200
acaggcaac  gtgagccaa  cattggcat  accatcctt  ctctagcta  aatttccct  4260
tcccccttt  atactgact  ttttgaact  tagtgttaa  tggaccttt  cgtacaaca  4320
actaaaata  agaatcttt  tcca  4344



<210> 8372
<211> 1291
<212> PRT
<213> Rattus norvegicus
<308> U32681
<400> 8372

Met Cys Asp Asp Ser Trp Asp Ile Asn Asp Ala Asn Val Val Cys Arg 
  1               5                  10                  15
Gln Leu Gly Cys Gly Trp Ala Leu Ser Ala Pro Gly Ser Ala Gln Phe 
             20                  25                  30
Gly Gln Gly Leu Gly Pro Ile Val Leu Asp Asp Val Ala Cys Arg Gly 
         35                  40                  45
His Glu Ala Tyr Leu Trp Ser Cys Ser His Arg Gly Trp Leu Ser His 
     50                  55                  60
Asn Cys Gly His Gln Glu Asp Ala Gly Val Ile Cys Ser Asp Ser Gln 
 65                  70                  75                  80
Thr Ser Ser Pro Thr Pro Gly Trp Trp Asn Pro Gly Gly Thr Asn Asn 
                 85                  90                  95
Asp Val Ile Tyr Asp Thr Gln Glu Thr Thr Glu Thr Ser Gln Thr Ser 
             100                105                110
Ser Pro Thr Pro Asp Trp Trp Asn His Gly Gly Thr Ile Asn Asp Val 
         115                120                125
Ile Tyr Asp Thr Gln Glu Thr Thr Glu Gly Thr Asp Ser Gly Leu Ala 
     130                135                140
Val Arg Leu Val Asn Gly Gly Asp Arg Cys Arg Gly Arg Val Glu Ile 
 145                150                155                160
Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Ile 
                 165                170                175
Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Leu 
             180                185                190
Ser Ala Pro Gly Ser Ala Gln Phe Gly Gln Gly Ser Gly Ser Ile Val 
         195                200                205
Leu Asp Asp Val Ala Cys Arg Gly His Glu Ala Tyr Leu Trp Ser Cys 
     210                215                220
Ser His Arg Gly Trp Leu Ser His Asn Cys Gly His Gln Glu Asp Ala 
 225                230                235                240
Gly Val Ile Cys Ser Tyr Ser Gln Thr Ser Ser Pro Thr Pro Asp Ser 
                 245                250                255
Gln Thr Ser Ser Pro Thr Pro Gly Trp Trp Asn Pro Gly Gly Thr Asn 
             260                265                270
Asn Asp Val Ser Tyr Gly Pro Glu Gln Thr Thr Asp Ala Thr Asp Ser 
         275                280                285
Gly Leu Ala Val Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg 
     290                295                300
Val Glu Ile Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp Ser 
 305                310                315                320
Trp Asp Thr Lys Asp Ala Asn Val Val Cys Arg Gln Leu Val Cys Gly 
                 325                330                335
Trp Ala Leu Ser Ala Pro Gly Ser Ala His Phe Gly Gln Gly Ser Gly 
             340                345                350
Ser Ile Val Leu Asp Asp Val Ala Cys Thr Gly His Glu Ala Tyr Leu 
         355                360                365
Trp Ser Cys Ser His Arg Gly Trp Leu Ser His Asn Cys Gly His His 
     370                375                380
Glu Asp Ala Gly Val Ile Cys Ser Asp Ala Gln Thr Gln Ser Thr Thr 
 385                390                395                400
Trp Pro Asp Met Trp Pro Thr Thr Thr Pro Glu Thr Thr Thr Asp Trp 
                 405                410                415
Trp Thr Thr Lys Tyr Ser Ser Ser Val Pro Thr Thr Gln Phe Pro Thr 
             420                425                430
Ile Ala Asp Trp Trp Thr Thr Pro Ser Pro Glu Tyr Thr Cys Gly Gly 
         435                440                445
Leu Leu Thr Leu Pro Tyr Gly Gln Phe Ser Ser Pro Tyr Tyr Pro Gly 
     450                455                460
Ser Tyr Pro Asn Asn Ala Arg Cys Leu Trp Lys Ile Phe Val Ser Ser 
 465                470                475                480
Met Asn Arg Val Thr Val Val Phe Thr Asp Val Gln Leu Glu Gly Gly 
                 485                490                495
Cys Asn Tyr Asp Tyr Ile Leu Val Phe Asp Gly Pro Glu Asn Asn Ser 
             500                505                510
Ser Leu Ile Ala Arg Val Cys Asp Gly Phe Asn Gly Ser Phe Thr Ser 
         515                520                525
Thr Gln Asn Phe Met Ser Val Val Phe Ile Thr Asp Gly Ser Val Thr 
     530                535                540
Arg Arg Gly Phe Gln Ala Asp Tyr Tyr Ser Thr Pro Ile Ser Thr Ser 
 545                550                555                560
Thr Thr Ser Pro Thr Thr Phe Pro Ile Val Thr Asp Trp Trp Thr Thr 
                 565                570                575
Pro Ser Pro Glu Tyr Thr Cys Gly Gly Leu Leu Thr Leu Pro Tyr Gly 
             580                585                590
Gln Phe Ser Ser Pro Tyr Tyr Pro Gly Ser Tyr Pro Asn Asn Ala Arg 
         595                600                605
Cys Leu Trp Lys Ile Phe Val Pro Ser Met Asn Arg Val Thr Val Val 
     610                615                620
Phe Thr Asp Val Gln Leu Glu Gly Gly Cys Asn Tyr Asp Tyr Ile Leu 
 625                630                635                640
Gly Phe Asp Gly Pro Glu Tyr Asn Ser Ser Leu Ile Ala Arg Val Cys 
                 645                650                655
Asp Gly Ser Asn Gly Ser Phe Thr Ser Thr Gln Asn Phe Met Ser Val 
             660                665                670
Val Phe Ile Thr Asp Gly Ser Val Thr Arg Arg Gly Phe Gln Ala Asp 
         675                680                685
Tyr Tyr Ser Thr Pro Ile Arg Thr Ser Thr Thr Pro Pro Thr Thr Phe 
     690                695                700
Pro Ile Ile Thr Gly Asn Asp Ser Ser Leu Val Leu Arg Leu Val Asn 
 705                710                715                720
Gly Thr Asn Arg Cys Glu Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser 
                 725                730                735
Trp Val Pro Cys Ala Asp Asp Ser Trp Asp Ile Asn Asp Ala Asn Val 
             740                745                750
Val Cys Arg Gln Leu Gly Cys Gly Ser Ala Leu Ser Ala Pro Gly Asn 
         755                760                765
Ala Trp Phe Gly Gln Gly Ser Gly Leu Ile Val Leu Asp Asp Val Ser 
     770                775                780
Cys Ser Gly Tyr Glu Ser His Leu Trp Asn Cys Arg His Pro Gly Trp 
 785                790                795                800
Leu Val His Asn Cys Arg His Val Glu Asp Ala Gly Val Ile Cys Ser 
                 805                810                815
Leu Pro Asp Pro Thr Pro Ser Pro Gly Pro Val Trp Thr Ser Pro Pro 
             820                825                830
Phe Val Asn Tyr Thr Cys Gly Gly Phe Leu Thr Gly Leu Ser Gly Gln 
         835                840                845
Phe Ser Ser Pro Tyr Tyr Pro Gly Ser Tyr Pro Asn Asn Ala Arg Cys 
     850                855                860
Leu Trp Asn Ile Glu Val Pro Asn Asn Tyr Arg Val Thr Val Val Phe 
 865                870                875                880
Arg Asp Val Gln Leu Glu Gly Gly Cys Asn Tyr Asp Tyr Ile Glu Ile 
                 885                890                895
Phe Asp Gly Pro His His Ser Ser Pro Leu Ile Ala Arg Val Cys Asp 
             900                905                910
Gly Ala Met Gly Ser Phe Thr Ser Thr Ser Asn Phe Met Ser Val Arg 
         915                920                925
Phe Thr Thr Asp His Ser Val Thr Arg Arg Gly Phe Arg Ala Asp Tyr 
     930                935                940
Tyr Ser Asp Phe Asp Asn Asn Thr Thr Asn Leu Leu Cys Leu Ser Asn 
 945                950                955                960
His Met Arg Ala Ser Val Ser Arg Ser Tyr Leu Gln Ser Met Gly Tyr 
                 965                970                975
Ser Ser Arg Asp Leu Val Ile Pro Gly Trp Asn Val Ser Tyr Gln Cys 
             980                985                990
Gln Pro Gln Ile Thr Gln Arg Glu Val Ile Phe Thr Ile Pro Tyr Thr 
         995                1000                1005
Gly Cys Gly Thr Thr Lys Gln Ala Asp Asn Glu Thr Ile Asn Tyr Ser 
     1010                1015                1020
Asn Phe Leu Lys Ala Ala Val Ser Asn Gly Ile Ile Lys Arg Arg Lys 
 1025                1030                1035                1040
Asp Leu His Ile His Val Ser Cys Lys Met Leu Gln Asn Thr Trp Val 
                 1045                1050                1055
Asn Thr Met Tyr Ile Thr Asn Asn Thr Val Glu Ile Gln Glu Val Gln 
             1060                1065                1070
Tyr Gly Asn Phe Asp Val Asn Ile Ser Phe Tyr Thr Ser Ser Ser Phe 
         1075                1080                1085
Leu Tyr Pro Val Thr Ser Ser Pro Tyr Tyr Val Asp Leu Asp Gln Asn 
     1090                1095                1100
Leu Tyr Leu Gln Ala Glu Val Leu His Ser Asp Thr Ser Leu Ala Leu 
 1105                1110                1115                1120
Phe Val Asp Thr Cys Val Ala Ser Pro His Pro Asn Asp Phe Ser Ser 
                 1125                1130                1135
Leu Thr Tyr Asp Leu Ile Arg Ser Gly Cys Ile Arg Asp Glu Thr Tyr 
             1140                1145                1150
Gln Ser Tyr Ser Ser Pro Ser Pro Arg Ile Thr Arg Phe Lys Phe Ser 
         1155                1160                1165
Ser Phe His Phe Leu Asn Arg Phe Pro Ser Val Tyr Leu Gln Cys Lys 
     1170                1175                1180
Leu Val Val Cys Arg Ala Asn Asp Val Ser Ser Arg Cys Tyr Arg Gly 
 1185                1190                1195                1200
Cys Val Val Arg Ser Lys Arg Asp Val Gly Ser Tyr Gln Glu Lys Val 
                 1205                1210                1215
Asp Val Val Leu Gly Pro Ile Gln Leu Gln Ser Pro Ser Lys Glu Lys 
             1220                1225                1230
Arg Ser Leu Asp Leu Ala Val Ala Asp Val Glu Lys Pro Ala Ser Ser 
         1235                1240                1245
Gln Glu Val Tyr Pro Thr Ala Ala Ile Phe Gly Gly Val Phe Leu Ala 
     1250                1255                1260
Leu Val Val Ala Val Ala Ala Phe Thr Leu Gly Arg Lys Thr Arg Thr 
 1265                1270                1275                1280
Ala Arg Gly Gln Pro Pro Ser Thr Lys Met Ter 
                 1285                1290



<210> 8373
<211> 7683
<212> DNA
<213> Homo sapiens
<308> AJ243212
<400> 8373

tttatagca  cagcagaaa  ataccaccc  agtggacac  cctcctttt  gctaggtac  60
tataaatgt  caggatttt  tattcaatt  agaagaacc  agcaaaatg  ggatctcca  120
agtcatcct  gaaatgtgt  ttttatggg  acaagttct  tctacaggt  ggtggatcc  180
aaggactac  gactacgct  cactgattc  ctcggaggt  cccttggat  caactgtag  240
agaaggttc  ccatttccc  cggagttga  cctggagtc  actgtagca  aaggttctc  300
gatttcctt  gagtcaacc  tggagacaa  tgtagcaga  ggttctctg  ttccctcag  360
gtcaaccct  gagtcaact  tagcagaag  atctgattc  ggtttggcc  tgaggctgg  420
gaatggaga  ggcaggtgt  agggccgag  ggagatcct  taccgaggc  cctggggcg  480
cgtgtgtga  gacagctgg  acaccaatg  tgccaacgt  gtctgtagg  agctgggtt  540
tggctgggc  atgtcagct  caggaaatg  ctggtttgg  cagggctca  gacccattg  600
cctggatga  gtgcgctgc  caggacacg  atcctacct  tggagctgc  cccacaatg  660
ctggctctc  cataactgt  gccatggtg  agatgctgg  gttatctgc  cagctgccc  720
gcctcagtc  acactcagg  cagaaagtt  gcctgtcag  atatcacca  ctgtaccca  780
agaaggatc  gaatccagt  tggccctga  gctggtgaa  ggaggcgac  ggtgtcgag  840
ccgggtgga  gtcctatac  gaggctcct  gggcaccgt  tgtgatgac  actgggaca  900
caatgatgc  aatgtggtc  gcaggcagc  gggctgtgg  tgggccatg  cagccccag  960
aaatgccca  tttggccag  gctcaggac  cattgtcct  gatgatgtg  gctgctcag  1020
acacgagtc  tacctgtgg  gctgccccc  caatggctg  ctcacccac  actgtggcc  1080
tagtgaaga  gctggtgtc  tctgctcag  tccccagtc  cggccgaca  ccagcccag  1140
tacttggcc  acctcacat  catcaacag  aggacctga  tccagtttg  ccctgaggc  1200
ggtgaatgg  ggtgacagg  gtcagggcc  agtggaggt  ctataccga  gctcctggg  1260
caccgtgtg  gatgatagc  gggacacca  tgacgccaa  gtggtctgc  ggcagctgg  1320
ctgtggctg  gccacgtca  ccccaggaa  tgcccggtt  ggccagggt  caggaccca  1380
tgtcctgga  gacgtgcgc  gctcaggct  tgagtccta  ctgtggagc  gcccccaca  1440
tggctggct  tcccataac  gtcagcaca  tgaagacgc  ggtgtcatc  gctcagctg  1500
ccactcctg  tcgacgccc  gtccagaca  gttgccgac  atcacctta  ctgcatcga  1560
agtaggatc  gaatccagt  tggccctga  gctggtgaa  ggaggtgac  ggtgtcagg  1620
ccgagtgga  gtcctatac  gaggctcct  gggcaccgt  tgtgatgac  gctgggaca  1680
caatgatgc  aatgtggtc  gcaggcagc  gggctgtgg  tgggccatg  tggccccag  1740
aaatgcccg  tttggtcag  gctcaggac  cattgtcct  gatgacgtg  gctgctcag  1800
gaatgagtc  tacttgtgg  gctgccccc  caatggctg  ctctcccat  actgtggcc  1860
tagtgaaga  gctggtgtc  tctgctcag  acctgaatc  agtttggcc  tgaggctgg  1920
gaatggagg  gacaggtgt  agggccgag  ggaggtcct  taccgaggc  cttggggca  1980
cgtgtgtga  gacagctgg  acaccaatg  tgccaatgt  gtctgcagg  agctgggct  2040
tggctgggc  atgtcagcc  caggaaatg  ccggtttgg  cagggctca  gacccattg  2100
cctggatga  gtgcgctgc  caggacatg  gtcctacct  tggagctgc  ccaacaatg  2160
ctggctctc  cacaactgt  gccatcatg  agatgctgg  gtcatctgc  cagctgccc  2220
gtcccggtc  acgcccagg  cagacacgt  gtcgaccat  acgttacct  catcgacag  2280
aggatctga  tccagtttg  ccctgaggc  ggtgaatgg  agtgacagg  gtcagggcc  2340
agtagaggt  ctataccga  gctcctggg  caccgtgtg  gatgacagc  gggatacca  2400
tgatgccaa  gtagtctgc  ggcagctgg  ctgtggctg  gccacgtcg  ccccaggaa  2460
tgcccggtt  ggccagggc  caggaccca  tgttctgga  gatgtgcgc  gctcaggac  2520
cgagtccta  ctgtggagc  gcccccaca  tggctggct  tcccacaac  gtggccatc  2580
tgaagatgc  ggtgtcatc  gctcagttt  ccagtcccg  ccgacaccc  gtccagata  2640
ttggccgac  tcacatgca  caacagcag  acctgaatc  agcttggcc  tgaggctgg  2700
gaatggagg  gacaggtgt  agggccgag  ggaggtcct  taccgaggc  cctggggca  2760
cgtgtgtga  gatagctgg  acaccagtg  cgccaatgt  gtctgccgg  agctgggct  2820
tggctgggc  acgtcagcc  caggaaatg  ccggtttgg  cagggttca  gacccattg  2880
cctggatga  gtgcgctgc  caggctatg  gtcctacct  tggagctgc  cccacaatg  2940
ctggctctc  cataactgt  agcacagtg  agacgctgg  gtcatctgc  cagctgccc  3000
ctcctggtc  acgcccagt  cagacacat  gccgaccat  accttgcct  catcgacag  3060
aggatctga  tccagtttg  ccctgaggc  ggtgaatgg  ggtgacagg  gtcagggcc  3120
agtggaggt  ctataccaa  gctcctggg  caccgtgtg  gatgacagc  gggacacca  3180
tgatgccaa  gtcgtctgc  ggcaactgg  ctgtggctg  gccatgtca  ccccaggaa  3240
tgcccggtt  ggtcagggc  caggaccca  tgtcctgga  gatgcgcgc  gctcaggac  3300
cgagtctta  ctgtggagc  gcccccaca  tggctggct  tcccacaac  gtggccata  3360
tgaagacgc  ggtgtcatc  gctcagctt  ccagtcccg  ccaacacct  gtccagaca  3420
ttggccaac  tcacatgca  caacagcag  atctgaatc  agtttggcc  tgaggctgg  3480
gaatggagg  gacaggtgt  agggccgag  ggaggtcct  taccgaggc  cctggggca  3540
cgtgtgtga  gactactgg  acaccaatg  tgccaatgt  gcttgcagg  agctgggct  3600
tggctgggc  atgtcagcc  caggaaatg  ccggtttgg  cagggttca  gacccattg  3660
cctggatga  gtgcgctgc  caggacatg  gtcctatct  tggagctgc  cccacaatg  3720
ctggctctc  cacaactgt  gccatcatg  agacgctgg  gtcatctgc  cagcttccc  3780
gtcccagcc  acacccagc  cagacactt  gccaacctc  catgcatca  cagcaggat  3840
tgaatccag  ttggccctg  ggctggtga  tggaggtga  aggtgtcag  gccgagtgg  3900
ggtcctata  cgaggctcc  ggggcaccg  gtgtgatga  tactgggac  ccaatgatg  3960
caatgtggt  tgcaggcag  tgggctgtg  ctgggccac  tcagcccca  gaaatgccc  4020
gtttggcca  ggttcagga  ccattgtcc  ggatgatgt  cgctgctca  gacatgagt  4080
ctatctgtg  agctgcccc  acaatggct  gctctccca  aactgtggc  atcatgaag  4140
cgctggtgt  atctgctca  cttcccagt  ccagccgac  cccagccca  acacttggc  4200
aacctcaca  gcatcaaca  caggatctg  atccagttt  gccctgagg  tggtgaatg  4260
aggtgacag  tgtcagggc  gagtggagg  cctataccg  ggctcctgg  gcaccgtgt  4320
tgatgacta  tgggacacc  atgatgcca  tgtggtttg  aggcagctg  gctgtggct  4380
ggccacgtc  gccccagga  atgcccggt  tggccaggg  tcaggaccc  ttgtcctgg  4440
tgatgtgcg  tgctcagga  atgagtcct  tctgtggag  tgcccccac  atggctggc  4500
ctcccacaa  tgtggccat  atgaagacg  tggtgtcat  tgctcagct  tccagtccc  4560
gccgacacc  agcccagac  cttggccaa  ctctcgtgc  tcaacagca  gatctgaat  4620
cactttggc  ctgagactg  tgaatggag  tgacaggtg  cgaggccga  tggaggtcc  4680
ataccaagg  tcctggggc  ccgtgtgtg  tgactactg  gacaccaat  atgccaacg  4740
ggtctgcag  cagctgggc  gtggctggg  catgtcagc  ccaggaaat  cccagtttg  4800
ccagggctc  ggacccatt  tcctggatg  tgtgcgctg  tcaggacac  agccttacc  4860
gtggagctg  ccccacaat  gctggctct  ccacaactg  ggccatcat  aagatgctg  4920
tgtcatctg  tcagctgct  agtcccagt  aacgcccag  ccagatact  ggctgacca  4980
caacttacc  gcattgaca  taggatctg  atccagttt  gctctgagg  tggtgaatg  5040
aggtgacag  tgtcgaggc  gagtggagg  cctgtatcg  ggctcctgg  gaaccgtgt  5100
tgatgacag  tgggacacc  atgatgcca  tgtggtctg  aggcagctg  gctgtggct  5160
ggccatgtc  gccccagga  atgcccggt  tggccaggg  tcaggaccc  ttgtcctgg  5220
tgatgtgcg  tgctcaggg  atgagtcct  cctgtggag  tgcccccac  aaggctggc  5280
cacccacaa  tgtggccat  acgaagacg  tggtgtcat  tgctcagcc  cccaaataa  5340
ttctactac  acagattgg  ggcatccaa  aactacaac  actgcaaga  cctcttcaa  5400
ttgtggtgg  ttcttattc  atgccagtg  gacattctc  agcccatcc  accctgcat  5460
ctaccccaa  aatgctaag  gtgtttggg  aatagaagt  aattctggt  atcgcataa  5520
cctgggctt  agtaatctg  aattggagg  acaccataa  tgcagtttt  attatgttg  5580
aatctttga  ggatcattg  atagcagtc  cctgctggg  aaaatctgt  atgatacca  5640
gcaaatatt  acatcttct  acaaccgaa  gaccattca  tttcgaagt  acatcagtt  5700
ccaaaacac  ggctttttg  cttggtata  ctccttccc  agcgatgcc  ccttgaggt  5760
ggtcaattt  aattcatcc  atggtctat  tgccgggcg  gtagaaatt  accatggtg  5820
cacctgggg  gcagtttgt  atgactcct  gaccattca  gaagctgag  tggtctgca  5880
acagctagg  tgtggacgt  cagtttcag  ccttggaaa  gcatatttt  gctctggct  5940
tggccccat  accctggac  atgtagagt  ctcagggac  gaatccact  tctggcagt  6000
ccggaaccg  ggctggttc  cccacaact  taatcatcg  gaagatgct  gtgtcatct  6060
ctcaggaaa  catctatcg  cacctgctc  ttttctcaa  atcacccgt  caaacaact  6120
ttcctgcgg  ggcttccta  cccaaccat  aggggactt  tccagccca  tctatcccg  6180
gaactatcc  aacaatgcc  agtgtgtgt  ggacattga  gtgcaaaac  actaccgtg  6240
gactgtgat  ttcagagat  tccagcttg  aggtggctg  aactatgat  atattgaag  6300
tttcgatgg  ccctaccgc  gttcccctc  cattgctcg  gtttgtgat  gggccagag  6360
ctccttcac  tcttcctcc  acttcatgt  cattcgctt  atcagtgac  acagcatca  6420
aaggagagg  ttccgggct  agtactact  cagtccctc  aatgacagc  ccaacctgc  6480
ctgtctgcc  aatcacatg  aagccagtg  gagcaggag  tatctccaa  ccttgggct  6540
ttctgccag  gaccttgtc  tttccacct  gaatggata  tacgagtgt  ggccccaga  6600
aacgccgaa  ctggtgata  tcacaattc  ctactcagg  tgcggcacc  tcaagcagg  6660
agacaatga  accatcgac  attccaacc  cctcacagc  gctgtctca  gtggcatca  6720
caagaggag  acagacctc  gtattcacg  cagctgcag  atgcttcag  acacctggg  6780
cgacaccat  tacattgct  atgacacca  ccacgttgc  aataacacc  tccaggtcg  6840
ggaagtcca  tatggcaat  ttgacgtga  catttcctt  tatacttcc  catctttct  6900
gtatcctgt  accagccgc  cttactacg  ggacctgaa  caggacttg  acgttcagg  6960
tgaaatcct  cattctgat  ctgtactga  cttgtttgt  gacacctgc  tggcatcac  7020
atactccaa  gacttcacg  ctttgactt  tgatctaat  cggagtgga  gcgtgaggg  7080
tgacaccta  ggaccctac  cctcgccat  tcttcgcat  gcccgcttc  ggttcaggg  7140
cttccactt  ctgaaccgc  tcccctccg  gtacctgcg  tgtaaaatg  tggtgtgca  7200
agcgtatga  ccctcttcc  gctgctacc  aggctgtgt  ttgaggtcg  agagggatg  7260
gggctccta  caggaaaag  tggacgtcg  cctgggtcc  atccagctg  agacccccc  7320
acgccgaga  gaggagcct  ggtaggtgg  cgctctcag  ccccattgt  caccggggc  7380
cagacccct  actcgggga  ttgggatgt  cctcttggt  tcatattcc  actcagatt  7440
agccctaca  tgtgctgca  ctggtcata  ggagttgaa  cagacctgg  tcccgcctc  7500
cccaaggct  atggtcctt  gaggacccg  tgcagggtg  ggtcaagag  gttctgacc  7560
ggatggccc  tagacctga  gtcccagaa  ccatgcttc  catctgcaa  atgaaaatg  7620
caatactta  ttcttagca  tgttgagag  gttacttac  taaaggaat  ttggtgaaa  7680
tgc  7683



<210> 8374
<211> 2413
<212> PRT
<213> Homo sapiens
<308> AJ243212
<400> 8374

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
  1               5                  10                  15
Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
             20                  25                  30
Leu Ile Pro Ser Glu Val Pro Leu Asp Thr Thr Val Ala Glu Gly Ser 
         35                  40                  45
Pro Phe Pro Ser Glu Leu Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
     50                  55                  60
Pro Ile Ser Leu Glu Ser Thr Leu Glu Thr Thr Val Ala Glu Gly Ser 
 65                  70                  75                  80
Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                 85                  90                  95
Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
             100                105                110
Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Ala Val Cys Asp 
         115                120                125
Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
     130                135                140
Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
 145                150                155                160
Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                 165                170                175
Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
             180                185                190
His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
         195                200                205
Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
     210                215                220
Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
 225                230                235                240
Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                 245                250                255
Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
             260                265                270
Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
         275                280                285
Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
     290                295                300
Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
 305                310                315                320
His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                 325                330                335
Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
             340                345                350
Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
         355                360                365
Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
     370                375                380
Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
 385                390                395                400
Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                 405                410                415
Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
             420                425                430
Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
         435                440                445
Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
     450                455                460
Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr Ile Thr 
 465                470                475                480
Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu 
                 485                490                495
Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
             500                505                510
Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala 
         515                520                525
Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Leu Ala Pro 
     530                535                540
Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
 545                550                555                560
Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
                 565                570                575
Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile 
             580                585                590
Cys Ser Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
         595                600                605
Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
     610                615                620
Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
 625                630                635                640
Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Arg 
                 645                650                655
Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
             660                665                670
Gly His Glu Ser Tyr Leu Trp Ser Cys Pro Asn Asn Gly Trp Leu Ser 
         675                680                685
His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Ala 
     690                695                700
Gln Ser Arg Ser Thr Pro Arg Pro Asp Thr Leu Ser Thr Ile Thr Leu 
 705                710                715                720
Pro Pro Ser Thr Val Gly Ser Glu Ser Ser Leu Thr Leu Arg Leu Val 
                 725                730                735
Asn Gly Ser Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly 
             740                745                750
Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn 
         755                760                765
Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly 
     770                775                780
Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val 
 785                790                795                800
Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly 
                 805                810                815
Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys 
             820                825                830
Ser Val Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr 
         835                840                845
Ser His Ala Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu 
     850                855                860
Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
 865                870                875                880
Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala 
                 885                890                895
Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro 
             900                905                910
Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
         915                920                925
Val Arg Cys Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
     930                935                940
Gly Trp Leu Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile 
 945                950                955                960
Cys Ser Ala Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro 
                 965                970                975
Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala 
             980                985                990
Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val 
         995                1000                1005
Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr 
     1010                1015                1020
Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met 
 1025                1030                1035                1040
Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val 
                 1045                1050                1055
Leu Asp Asp Ala Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys 
             1060                1065                1070
Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala 
         1075                1080                1085
Gly Val Ile Cys Ser Ala Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp 
     1090                1095                1100
Thr Trp Pro Thr Ser His Ala Ser Thr Ala Gly Ser Glu Ser Ser Leu 
 1105                1110                1115                1120
Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu 
                 1125                1130                1135
Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp 
             1140                1145                1150
Thr Asn Asp Ala Asn Val Ala Cys Arg Gln Leu Gly Cys Gly Trp Ala 
         1155                1160                1165
Met Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile 
     1170                1175                1180
Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser 
 1185                1190                1195                1200
Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp 
                 1205                1210                1215
Ala Gly Val Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr Pro Ser Pro 
             1220                1225                1230
Asp Thr Trp Pro Thr Ser His Ala Ser Thr Ala Gly Ser Glu Ser Ser 
         1235                1240                1245
Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val 
     1250                1255                1260
Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp 
 1265                1270                1275                1280
Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp 
                 1285                1290                1295
Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro 
             1300                1305                1310
Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp 
         1315                1320                1325
Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu 
     1330                1335                1340
Asp Ala Gly Val Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr Pro Ser 
 1345                1350                1355                1360
Pro Asp Thr Trp Pro Thr Ser His Ala Ser Thr Ala Gly Ser Glu Ser 
                 1365                1370                1375
Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg 
             1380                1385                1390
Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr 
         1395                1400                1405
Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly 
     1410                1415                1420
Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly 
 1425                1430                1435                1440
Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu 
                 1445                1450                1455
Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His His 
             1460                1465                1470
Glu Asp Ala Gly Val Ile Cys Ser Ala Phe Gln Ser Gln Pro Thr Pro 
         1475                1480                1485
Ser Pro Asp Thr Trp Pro Thr Ser Arg Ala Ser Thr Ala Gly Ser Glu 
     1490                1495                1500
Ser Thr Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Arg Gly 
 1505                1510                1515                1520
Arg Val Glu Val Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp 
                 1525                1530                1535
Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys 
             1540                1545                1550
Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln Phe Gly Gln Gly Ser 
         1555                1560                1565
Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Pro Tyr 
     1570                1575                1580
Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His 
 1585                1590                1595                1600
His Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Ser Gln Ser Thr 
                 1605                1610                1615
Pro Arg Pro Asp Thr Trp Leu Thr Thr Asn Leu Pro Ala Leu Thr Val 
             1620                1625                1630
Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg 
         1635                1640                1645
Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val 
     1650                1655                1660
Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln 
 1665                1670                1675                1680
Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Arg Phe Gly 
                 1685                1690                1695
Gln Gly Ser Gly Pro Ile Val Leu Gly Asp Val Arg Cys Ser Gly Asn 
             1700                1705                1710
Glu Ser Tyr Leu Trp Ser Cys Pro His Lys Gly Trp Leu Thr His Asn 
         1715                1720                1725
Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Thr Gln Ile 
     1730                1735                1740
Asn Ser Thr Thr Thr Asp Trp Trp His Pro Thr Thr Thr Thr Thr Ala 
 1745                1750                1755                1760
Arg Pro Ser Ser Asn Cys Gly Gly Phe Leu Phe Tyr Ala Ser Gly Thr 
                 1765                1770                1775
Phe Ser Ser Pro Ser Tyr Pro Ala Tyr Tyr Pro Asn Asn Ala Lys Cys 
             1780                1785                1790
Val Trp Glu Ile Glu Val Asn Ser Gly Tyr Arg Ile Asn Leu Gly Phe 
         1795                1800                1805
Ser Asn Leu Lys Leu Glu Ala His His Asn Cys Ser Phe Asp Tyr Val 
     1810                1815                1820
Glu Ile Phe Asp Gly Ser Leu Asn Ser Ser Leu Leu Leu Gly Lys Ile 
 1825                1830                1835                1840
Cys Asn Asp Thr Arg Gln Ile Phe Thr Ser Ser Tyr Asn Arg Met Thr 
                 1845                1850                1855
Ile His Phe Arg Ser Asp Ile Ser Phe Gln Asn Thr Gly Phe Leu Ala 
             1860                1865                1870
Trp Tyr Asn Ser Phe Pro Ser Asp Ala Thr Leu Arg Leu Val Asn Leu 
         1875                1880                1885
Asn Ser Ser Tyr Gly Leu Cys Ala Gly Arg Val Glu Ile Tyr His Gly 
     1890                1895                1900
Gly Thr Trp Gly Ala Val Cys Asp Asp Ser Trp Thr Ile Gln Glu Ala 
 1905                1910                1915                1920
Glu Val Val Cys Arg Gln Leu Gly Cys Gly Arg Ala Val Ser Ala Leu 
                 1925                1930                1935
Gly Asn Ala Tyr Phe Gly Ser Gly Ser Gly Pro Ile Thr Leu Asp Asp 
             1940                1945                1950
Val Glu Cys Ser Gly Thr Glu Ser Thr Leu Trp Gln Cys Arg Asn Arg 
         1955                1960                1965
Gly Trp Phe Ser His Asn Cys Asn His Arg Glu Asp Ala Gly Val Ile 
     1970                1975                1980
Cys Ser Gly Asn His Leu Ser Thr Pro Ala Pro Phe Leu Asn Ile Thr 
 1985                1990                1995                2000
Arg Pro Asn Asn Tyr Ser Cys Gly Gly Phe Leu Ser Gln Pro Ser Gly 
                 2005                2010                2015
Asp Phe Ser Ser Pro Phe Tyr Pro Gly Asn Tyr Pro Asn Asn Ala Lys 
             2020                2025                2030
Cys Val Trp Asp Ile Glu Val Gln Asn Asn Tyr Arg Val Thr Val Ile 
         2035                2040                2045
Phe Arg Asp Val Gln Leu Glu Gly Gly Cys Asn Tyr Asp Tyr Ile Glu 
     2050                2055                2060
Val Phe Asp Gly Pro Tyr Arg Ser Ser Pro Leu Ile Ala Arg Val Cys 
 2065                2070                2075                2080
Asp Gly Ala Arg Gly Ser Phe Thr Ser Ser Ser Asn Phe Met Ser Ile 
                 2085                2090                2095
Arg Phe Ile Ser Asp His Ser Ile Thr Arg Arg Gly Phe Arg Ala Glu 
             2100                2105                2110
Tyr Tyr Ser Ser Pro Ser Asn Asp Ser Thr Asn Leu Leu Cys Leu Pro 
         2115                2120                2125
Asn His Met Gln Ala Ser Val Ser Arg Ser Tyr Leu Gln Ser Leu Gly 
     2130                2135                2140
Phe Ser Ala Ser Asp Leu Val Ile Ser Thr Trp Asn Gly Tyr Tyr Glu 
 2145                2150                2155                2160
Cys Arg Pro Gln Ile Thr Pro Asn Leu Val Ile Phe Thr Ile Pro Tyr 
                 2165                2170                2175
Ser Gly Cys Gly Thr Phe Lys Gln Ala Asp Asn Asp Thr Ile Asp Tyr 
             2180                2185                2190
Ser Asn Leu Leu Thr Ala Ala Val Ser Gly Gly Ile Ile Lys Arg Arg 
         2195                2200                2205
Thr Asp Leu Arg Ile His Val Ser Cys Arg Met Leu Gln Asn Thr Trp 
     2210                2215                2220
Val Asp Thr Met Tyr Ile Ala Asn Asp Thr Ile His Val Ala Asn Asn 
 2225                2230                2235                2240
Thr Ile Gln Val Glu Glu Val Gln Tyr Gly Asn Phe Asp Val Asn Ile 
                 2245                2250                2255
Ser Phe Tyr Thr Ser Ser Ser Phe Leu Tyr Pro Val Thr Ser Arg Pro 
             2260                2265                2270
Tyr Tyr Val Asp Leu Asn Gln Asp Leu Tyr Val Gln Ala Glu Ile Leu 
         2275                2280                2285
His Ser Asp Ala Val Leu Thr Leu Phe Val Asp Thr Cys Val Ala Ser 
     2290                2295                2300
Pro Tyr Ser Asn Asp Phe Thr Ser Leu Thr Tyr Asp Leu Ile Arg Ser 
 2305                2310                2315                2320
Gly Cys Val Arg Asp Asp Thr Tyr Gly Pro Tyr Ser Ser Pro Ser Leu 
                 2325                2330                2335
Arg Ile Ala Arg Phe Arg Phe Arg Ala Phe His Phe Leu Asn Arg Phe 
             2340                2345                2350
Pro Ser Val Tyr Leu Arg Cys Lys Met Val Val Cys Arg Ala Tyr Asp 
         2355                2360                2365
Pro Ser Ser Arg Cys Tyr Arg Gly Cys Val Leu Arg Ser Lys Arg Asp 
     2370                2375                2380
Val Gly Ser Tyr Gln Glu Lys Val Asp Val Val Leu Gly Pro Ile Gln 
 2385                2390                2395                2400
Leu Gln Thr Pro Pro Arg Arg Glu Glu Glu Pro Arg Ter 
                 2405                2410



<210> 8375
<211> 4344
<212> DNA
<213> Rattus norvegicus
<308> U32681
<400> 8375

ggaacagat  ctggtttgg  tgtgaggct  gtgaatgga  gagacaggt  tcggggtcg  60
gtggagatc  tttaccagg  ttcctgggg  accatgtgt  atgacagct  ggacatcaa  120
gatgccaac  tggtgtgca  gcagctggg  tgtggctgg  ccttgtctg  cccaggaag  180
gcccagttt  gacagggtc  gggtcccat  gttctggat  acgtggcct  tagaggaca  240
gaggcctat  tgtggagct  ctcccaccg  ggctggctc  ctcataact  tggacatca  300
gaggatgct  gagtgatct  ctcagattc  caaacaagc  gtcccacac  cggttggtg  360
aaccccggg  gcacaaata  cgatgtgat  tacgacact  aagaaacca  agaaacttc  420
caaacaagc  gtcccacac  tgattggtg  aaccatggg  gcacaatta  tgatgtgat  480
tatgacact  aagaaacca  agaaggaac  gattctggt  tggctgtga  gctggtgaa  540
ggaggagac  ggtgtcggg  tcgtgtgga  atcctttac  agggttcct  gggcaccgt  600
tgtgacgac  gctgggaca  caatgatgc  aacgtggtg  gcaggcagc  gggctgtgg  660
tgggccttg  ctgccccag  aagtgccca  tttggacag  gctctgggt  cattgttct  720
gatgacgtg  cctgtagag  acatgaggc  tatctgtgg  gctgctccc  ccgaggctg  780
ctctctcat  actgtggac  tcaggagga  gctggagtc  tctgttcat  ttctcaaac  840
agcagtccc  cacccgatt  tcaaacaag  agtcccaca  ccggttggt  gaaccccgg  900
ggcacaaat  acgatgtgt  ctatggacc  gaacagacc  cagacgcaa  agattctgg  960
ttggctgtg  ggctggtga  tggaggaga  aggtgtcag  gtcgtgtgg  gatccttta  1020
cagggttcc  ggggtaccg  gtgtgacga  agctgggac  ccaaggatg  caacgtggt  1080
tgcaggcag  tggtctgtg  ctgggcctt  tctgcccca  gaagtgccc  ctttggaca  1140
ggctctgga  ccattgttc  ggatgacgt  gcctgtaca  gacatgagg  ctatctgtg  1200
agctgctcc  accgaggct  gctctctca  aactgtggc  accatgagg  tgctggagt  1260
atctgttca  atgcccaaa  ccagagcac  acctggcca  atatgtggc  tactaccac  1320
ccagaaact  caacagatt  gtggactac  aaatattct  cctctgttc  tacaacaca  1380
ttccccacc  tagccgatt  gtggacaac  ccttctccg  aatacacct  tggaggttt  1440
ctgacccta  cctatgggc  gttttccag  ccatactac  ctggaagct  tcctaacaa  1500
gccagatgt  tgtggaaaa  tttcgtctc  agcatgaac  gtgtgacag  ggtcttcac  1560
gatgtgcag  ttgaaggag  ttgcaacta  gactacatc  tggtttttg  tggccctga  1620
aacaattct  ctctcattg  tcgggtttg  gatgggttc  atggatctt  cacctcaac  1680
cagaacttc  tgtctgtag  ctttatcac  gatggcagt  tcacgagga  agggttcca  1740
gctgactac  actccactc  tatcagcac  agcacaacc  ctccaacga  gttcccgat  1800
gttactgat  ggtggacaa  tccttctcc  gaatacacc  gtggaggtt  actgaccct  1860
ccctatggg  agttttcca  cccatacta  cctggaagc  atcctaaca  tgccagatg  1920
ttgtggaaa  ttttcgtcc  cagcatgaa  cgtgtgaca  tggtcttca  agatgtgca  1980
cttgaagga  gttgcaact  tgactacat  ctgggtttt  atggtcctg  atacaattc  2040
tctctcatt  ctcgggttt  tgatgggtc  aatggatct  tcacctcaa  ccagaactt  2100
atgtctgta  tctttatca  ggatggcag  gtcacgagg  gagggttcc  agctgacta  2160
tactccact  ctatcagga  cagcacaac  cctccaacg  cgttcccga  cattactgg  2220
aatgattct  cattggtgc  gaggctggt  aatggaaca  accggtgtg  gggccgagt  2280
gagatcttg  acagaggct  ttgggtacc  tgtgccgac  acagctggg  catcaatga  2340
gccaatgtg  tctgcagac  gctcggttg  ggctctgct  tgtctgctc  aggaaatgc  2400
tggtttggt  agggttcag  gctcattgt  ctggatgat  tgtcttgct  tgggtatga  2460
tcccacctg  ggaattgtc  tcaccctgg  tggcttgtt  ataattgtc  tcatgttga  2520
gatgcagga  tcatttgct  actccctga  ccgactccc  ctcctggtc  agtttggac  2580
agtcctcct  ttgtaaact  tacttgtgg  ggtttcctg  ctggactct  tgggcaatt  2640
tctagccca  actaccctg  gagctatcc  aataatgcc  gatgtttgt  gaacattga  2700
gtcccaaac  actaccgcg  gactgtggt  ttcagagat  tgcagctgg  agggggctg  2760
aactatgac  atatagaga  ttttgatgg  ccccaccac  gttcacctc  cattgcccg  2820
gtttgtgat  gggccatgg  ctctttcac  tcaacatcc  acttcatgt  agttcgctt  2880
accactgat  acagtgtta  tcgaagagg  ttccgggct  actactact  agactttga  2940
aataatacc  ccaatctcc  ttgtctgtc  aatcacatg  gagccagtg  gagcaggag  3000
taccttcag  ccatgggct  ctcctccag  gatcttgtc  ttcctggtt  gaacgtgag  3060
taccagtgt  agcctcaga  aacacaaag  gaggtcata  tcacaattc  ctacacagg  3120
tgcggtact  ccaaacagg  tgacaacga  accatcaac  actccaact  cctcaaagc  3180
gctgtttca  atggcatca  caaaaggag  aaggatctc  acatccatg  cagctgcaa  3240
atgcttcag  acacctggg  caacaccat  tacatcacc  acaacacag  cgagatcca  3300
gaagtccag  atggcaatt  tgacgtgaa  atttccttt  atacatcct  ctccttctt  3360
tatccagtg  ccagcagcc  atattatgt  gatctggac  agaatttgt  ccttcaggc  3420
gaagtcctc  attcggata  ctctttggc  ctgtttgtg  acacctgtg  ggcttcgcc  3480
catcccaat  acttctcgt  tttgacata  gatctcatc  ggagtggat  catacgaga  3540
gaaacttac  aatcttact  ctcgccctc  ccacgcatc  cccgcttta  attcagttc  3600
ttccacttc  tgaaccgct  cccctcagt  tacctacag  gtaaactgg  ggtttgtcg  3660
gcaaacgat  tctcctcac  gtgctacag  ggatgtgta  taaggtcca  gagggatgt  3720
ggctcctac  aagaaaagg  ggatgttgt  ctgggaccc  tccagttgc  atctcccag  3780
aaagaaaag  ggagtctcg  cttggcagt  gcagatgtg  agaagccag  cagctccca  3840
gaggtctat  ccactgcag  catctttgg  ggagtcttc  tggccctgg  tgtagctgt  3900
gcagccttc  cactgggaa  gaagacacg  actgcccgt  gtcaacctc  aagtactaa  3960
atgtgaagc  aaacaaccc  gacattggt  ccaaatgca  agattccca  aaaagatgg  4020
agtcaggag  gtctaatgc  tggcaccca  atacacgat  actaggctt  ccttagcac  4080
aatgtgtgg  cgagtatga  cagatggta  agaagaaag  tgggggcca  gttttccca  4140
ggtctagag  ctgaaggct  ggaagaatg  cataggaga  tgagatcag  gtctacaat  4200
acaggcaac  gtgagccaa  cattggcat  accatcctt  ctctagcta  aatttccct  4260
tcccccttt  atactgact  ttttgaact  tagtgttaa  tggaccttt  cgtacaaca  4320
actaaaata  agaatcttt  tcca  4344



<210> 8376
<211> 1291
<212> PRT
<213> Rattus norvegicus
<308> U32681
<400> 8376

Met Cys Asp Asp Ser Trp Asp Ile Asn Asp Ala Asn Val Val Cys Arg 
  1               5                  10                  15
Gln Leu Gly Cys Gly Trp Ala Leu Ser Ala Pro Gly Ser Ala Gln Phe 
             20                  25                  30
Gly Gln Gly Leu Gly Pro Ile Val Leu Asp Asp Val Ala Cys Arg Gly 
         35                  40                  45
His Glu Ala Tyr Leu Trp Ser Cys Ser His Arg Gly Trp Leu Ser His 
     50                  55                  60
Asn Cys Gly His Gln Glu Asp Ala Gly Val Ile Cys Ser Asp Ser Gln 
 65                  70                  75                  80
Thr Ser Ser Pro Thr Pro Gly Trp Trp Asn Pro Gly Gly Thr Asn Asn 
                 85                  90                  95
Asp Val Ile Tyr Asp Thr Gln Glu Thr Thr Glu Thr Ser Gln Thr Ser 
             100                105                110
Ser Pro Thr Pro Asp Trp Trp Asn His Gly Gly Thr Ile Asn Asp Val 
         115                120                125
Ile Tyr Asp Thr Gln Glu Thr Thr Glu Gly Thr Asp Ser Gly Leu Ala 
     130                135                140
Val Arg Leu Val Asn Gly Gly Asp Arg Cys Arg Gly Arg Val Glu Ile 
 145                150                155                160
Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Ile 
                 165                170                175
Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Leu 
             180                185                190
Ser Ala Pro Gly Ser Ala Gln Phe Gly Gln Gly Ser Gly Ser Ile Val 
         195                200                205
Leu Asp Asp Val Ala Cys Arg Gly His Glu Ala Tyr Leu Trp Ser Cys 
     210                215                220
Ser His Arg Gly Trp Leu Ser His Asn Cys Gly His Gln Glu Asp Ala 
 225                230                235                240
Gly Val Ile Cys Ser Tyr Ser Gln Thr Ser Ser Pro Thr Pro Asp Ser 
                 245                250                255
Gln Thr Ser Ser Pro Thr Pro Gly Trp Trp Asn Pro Gly Gly Thr Asn 
             260                265                270
Asn Asp Val Ser Tyr Gly Pro Glu Gln Thr Thr Asp Ala Thr Asp Ser 
         275                280                285
Gly Leu Ala Val Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg 
     290                295                300
Val Glu Ile Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp Ser 
 305                310                315                320
Trp Asp Thr Lys Asp Ala Asn Val Val Cys Arg Gln Leu Val Cys Gly 
                 325                330                335
Trp Ala Leu Ser Ala Pro Gly Ser Ala His Phe Gly Gln Gly Ser Gly 
             340                345                350
Ser Ile Val Leu Asp Asp Val Ala Cys Thr Gly His Glu Ala Tyr Leu 
         355                360                365
Trp Ser Cys Ser His Arg Gly Trp Leu Ser His Asn Cys Gly His His 
     370                375                380
Glu Asp Ala Gly Val Ile Cys Ser Asp Ala Gln Thr Gln Ser Thr Thr 
 385                390                395                400
Trp Pro Asp Met Trp Pro Thr Thr Thr Pro Glu Thr Thr Thr Asp Trp 
                 405                410                415
Trp Thr Thr Lys Tyr Ser Ser Ser Val Pro Thr Thr Gln Phe Pro Thr 
             420                425                430
Ile Ala Asp Trp Trp Thr Thr Pro Ser Pro Glu Tyr Thr Cys Gly Gly 
         435                440                445
Leu Leu Thr Leu Pro Tyr Gly Gln Phe Ser Ser Pro Tyr Tyr Pro Gly 
     450                455                460
Ser Tyr Pro Asn Asn Ala Arg Cys Leu Trp Lys Ile Phe Val Ser Ser 
 465                470                475                480
Met Asn Arg Val Thr Val Val Phe Thr Asp Val Gln Leu Glu Gly Gly 
                 485                490                495
Cys Asn Tyr Asp Tyr Ile Leu Val Phe Asp Gly Pro Glu Asn Asn Ser 
             500                505                510
Ser Leu Ile Ala Arg Val Cys Asp Gly Phe Asn Gly Ser Phe Thr Ser 
         515                520                525
Thr Gln Asn Phe Met Ser Val Val Phe Ile Thr Asp Gly Ser Val Thr 
     530                535                540
Arg Arg Gly Phe Gln Ala Asp Tyr Tyr Ser Thr Pro Ile Ser Thr Ser 
 545                550                555                560
Thr Thr Ser Pro Thr Thr Phe Pro Ile Val Thr Asp Trp Trp Thr Thr 
                 565                570                575
Pro Ser Pro Glu Tyr Thr Cys Gly Gly Leu Leu Thr Leu Pro Tyr Gly 
             580                585                590
Gln Phe Ser Ser Pro Tyr Tyr Pro Gly Ser Tyr Pro Asn Asn Ala Arg 
         595                600                605
Cys Leu Trp Lys Ile Phe Val Pro Ser Met Asn Arg Val Thr Val Val 
     610                615                620
Phe Thr Asp Val Gln Leu Glu Gly Gly Cys Asn Tyr Asp Tyr Ile Leu 
 625                630                635                640
Gly Phe Asp Gly Pro Glu Tyr Asn Ser Ser Leu Ile Ala Arg Val Cys 
                 645                650                655
Asp Gly Ser Asn Gly Ser Phe Thr Ser Thr Gln Asn Phe Met Ser Val 
             660                665                670
Val Phe Ile Thr Asp Gly Ser Val Thr Arg Arg Gly Phe Gln Ala Asp 
         675                680                685
Tyr Tyr Ser Thr Pro Ile Arg Thr Ser Thr Thr Pro Pro Thr Thr Phe 
     690                695                700
Pro Ile Ile Thr Gly Asn Asp Ser Ser Leu Val Leu Arg Leu Val Asn 
 705                710                715                720
Gly Thr Asn Arg Cys Glu Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser 
                 725                730                735
Trp Val Pro Cys Ala Asp Asp Ser Trp Asp Ile Asn Asp Ala Asn Val 
             740                745                750
Val Cys Arg Gln Leu Gly Cys Gly Ser Ala Leu Ser Ala Pro Gly Asn 
         755                760                765
Ala Trp Phe Gly Gln Gly Ser Gly Leu Ile Val Leu Asp Asp Val Ser 
     770                775                780
Cys Ser Gly Tyr Glu Ser His Leu Trp Asn Cys Arg His Pro Gly Trp 
 785                790                795                800
Leu Val His Asn Cys Arg His Val Glu Asp Ala Gly Val Ile Cys Ser 
                 805                810                815
Leu Pro Asp Pro Thr Pro Ser Pro Gly Pro Val Trp Thr Ser Pro Pro 
             820                825                830
Phe Val Asn Tyr Thr Cys Gly Gly Phe Leu Thr Gly Leu Ser Gly Gln 
         835                840                845
Phe Ser Ser Pro Tyr Tyr Pro Gly Ser Tyr Pro Asn Asn Ala Arg Cys 
     850                855                860
Leu Trp Asn Ile Glu Val Pro Asn Asn Tyr Arg Val Thr Val Val Phe 
 865                870                875                880
Arg Asp Val Gln Leu Glu Gly Gly Cys Asn Tyr Asp Tyr Ile Glu Ile 
                 885                890                895
Phe Asp Gly Pro His His Ser Ser Pro Leu Ile Ala Arg Val Cys Asp 
             900                905                910
Gly Ala Met Gly Ser Phe Thr Ser Thr Ser Asn Phe Met Ser Val Arg 
         915                920                925
Phe Thr Thr Asp His Ser Val Thr Arg Arg Gly Phe Arg Ala Asp Tyr 
     930                935                940
Tyr Ser Asp Phe Asp Asn Asn Thr Thr Asn Leu Leu Cys Leu Ser Asn 
 945                950                955                960
His Met Arg Ala Ser Val Ser Arg Ser Tyr Leu Gln Ser Met Gly Tyr 
                 965                970                975
Ser Ser Arg Asp Leu Val Ile Pro Gly Trp Asn Val Ser Tyr Gln Cys 
             980                985                990
Gln Pro Gln Ile Thr Gln Arg Glu Val Ile Phe Thr Ile Pro Tyr Thr 
         995                1000                1005
Gly Cys Gly Thr Thr Lys Gln Ala Asp Asn Glu Thr Ile Asn Tyr Ser 
     1010                1015                1020
Asn Phe Leu Lys Ala Ala Val Ser Asn Gly Ile Ile Lys Arg Arg Lys 
 1025                1030                1035                1040
Asp Leu His Ile His Val Ser Cys Lys Met Leu Gln Asn Thr Trp Val 
                 1045                1050                1055
Asn Thr Met Tyr Ile Thr Asn Asn Thr Val Glu Ile Gln Glu Val Gln 
             1060                1065                1070
Tyr Gly Asn Phe Asp Val Asn Ile Ser Phe Tyr Thr Ser Ser Ser Phe 
         1075                1080                1085
Leu Tyr Pro Val Thr Ser Ser Pro Tyr Tyr Val Asp Leu Asp Gln Asn 
     1090                1095                1100
Leu Tyr Leu Gln Ala Glu Val Leu His Ser Asp Thr Ser Leu Ala Leu 
 1105                1110                1115                1120
Phe Val Asp Thr Cys Val Ala Ser Pro His Pro Asn Asp Phe Ser Ser 
                 1125                1130                1135
Leu Thr Tyr Asp Leu Ile Arg Ser Gly Cys Ile Arg Asp Glu Thr Tyr 
             1140                1145                1150
Gln Ser Tyr Ser Ser Pro Ser Pro Arg Ile Thr Arg Phe Lys Phe Ser 
         1155                1160                1165
Ser Phe His Phe Leu Asn Arg Phe Pro Ser Val Tyr Leu Gln Cys Lys 
     1170                1175                1180
Leu Val Val Cys Arg Ala Asn Asp Val Ser Ser Arg Cys Tyr Arg Gly 
 1185                1190                1195                1200
Cys Val Val Arg Ser Lys Arg Asp Val Gly Ser Tyr Gln Glu Lys Val 
                 1205                1210                1215
Asp Val Val Leu Gly Pro Ile Gln Leu Gln Ser Pro Ser Lys Glu Lys 
             1220                1225                1230
Arg Ser Leu Asp Leu Ala Val Ala Asp Val Glu Lys Pro Ala Ser Ser 
         1235                1240                1245
Gln Glu Val Tyr Pro Thr Ala Ala Ile Phe Gly Gly Val Phe Leu Ala 
     1250                1255                1260
Leu Val Val Ala Val Ala Ala Phe Thr Leu Gly Arg Lys Thr Arg Thr 
 1265                1270                1275                1280
Ala Arg Gly Gln Pro Pro Ser Thr Lys Met Ter 
                 1285                1290



<210> 8377
<211> 7683
<212> DNA
<213> Homo sapiens
<308> AJ243212
<400> 8377

tttatagca  cagcagaaa  ataccaccc  agtggacac  cctcctttt  gctaggtac  60
tataaatgt  caggatttt  tattcaatt  agaagaacc  agcaaaatg  ggatctcca  120
agtcatcct  gaaatgtgt  ttttatggg  acaagttct  tctacaggt  ggtggatcc  180
aaggactac  gactacgct  cactgattc  ctcggaggt  cccttggat  caactgtag  240
agaaggttc  ccatttccc  cggagttga  cctggagtc  actgtagca  aaggttctc  300
gatttcctt  gagtcaacc  tggagacaa  tgtagcaga  ggttctctg  ttccctcag  360
gtcaaccct  gagtcaact  tagcagaag  atctgattc  ggtttggcc  tgaggctgg  420
gaatggaga  ggcaggtgt  agggccgag  ggagatcct  taccgaggc  cctggggcg  480
cgtgtgtga  gacagctgg  acaccaatg  tgccaacgt  gtctgtagg  agctgggtt  540
tggctgggc  atgtcagct  caggaaatg  ctggtttgg  cagggctca  gacccattg  600
cctggatga  gtgcgctgc  caggacacg  atcctacct  tggagctgc  cccacaatg  660
ctggctctc  cataactgt  gccatggtg  agatgctgg  gttatctgc  cagctgccc  720
gcctcagtc  acactcagg  cagaaagtt  gcctgtcag  atatcacca  ctgtaccca  780
agaaggatc  gaatccagt  tggccctga  gctggtgaa  ggaggcgac  ggtgtcgag  840
ccgggtgga  gtcctatac  gaggctcct  gggcaccgt  tgtgatgac  actgggaca  900
caatgatgc  aatgtggtc  gcaggcagc  gggctgtgg  tgggccatg  cagccccag  960
aaatgccca  tttggccag  gctcaggac  cattgtcct  gatgatgtg  gctgctcag  1020
acacgagtc  tacctgtgg  gctgccccc  caatggctg  ctcacccac  actgtggcc  1080
tagtgaaga  gctggtgtc  tctgctcag  tccccagtc  cggccgaca  ccagcccag  1140
tacttggcc  acctcacat  catcaacag  aggacctga  tccagtttg  ccctgaggc  1200
ggtgaatgg  ggtgacagg  gtcagggcc  agtggaggt  ctataccga  gctcctggg  1260
caccgtgtg  gatgatagc  gggacacca  tgacgccaa  gtggtctgc  ggcagctgg  1320
ctgtggctg  gccacgtca  ccccaggaa  tgcccggtt  ggccagggt  caggaccca  1380
tgtcctgga  gacgtgcgc  gctcaggct  tgagtccta  ctgtggagc  gcccccaca  1440
tggctggct  tcccataac  gtcagcaca  tgaagacgc  ggtgtcatc  gctcagctg  1500
ccactcctg  tcgacgccc  gtccagaca  gttgccgac  atcacctta  ctgcatcga  1560
agtaggatc  gaatccagt  tggccctga  gctggtgaa  ggaggtgac  ggtgtcagg  1620
ccgagtgga  gtcctatac  gaggctcct  gggcaccgt  tgtgatgac  gctgggaca  1680
caatgatgc  aatgtggtc  gcaggcagc  gggctgtgg  tgggccatg  tggccccag  1740
aaatgcccg  tttggtcag  gctcaggac  cattgtcct  gatgacgtg  gctgctcag  1800
gaatgagtc  tacttgtgg  gctgccccc  caatggctg  ctctcccat  actgtggcc  1860
tagtgaaga  gctggtgtc  tctgctcag  acctgaatc  agtttggcc  tgaggctgg  1920
gaatggagg  gacaggtgt  agggccgag  ggaggtcct  taccgaggc  cttggggca  1980
cgtgtgtga  gacagctgg  acaccaatg  tgccaatgt  gtctgcagg  agctgggct  2040
tggctgggc  atgtcagcc  caggaaatg  ccggtttgg  cagggctca  gacccattg  2100
cctggatga  gtgcgctgc  caggacatg  gtcctacct  tggagctgc  ccaacaatg  2160
ctggctctc  cacaactgt  gccatcatg  agatgctgg  gtcatctgc  cagctgccc  2220
gtcccggtc  acgcccagg  cagacacgt  gtcgaccat  acgttacct  catcgacag  2280
aggatctga  tccagtttg  ccctgaggc  ggtgaatgg  agtgacagg  gtcagggcc  2340
agtagaggt  ctataccga  gctcctggg  caccgtgtg  gatgacagc  gggatacca  2400
tgatgccaa  gtagtctgc  ggcagctgg  ctgtggctg  gccacgtcg  ccccaggaa  2460
tgcccggtt  ggccagggc  caggaccca  tgttctgga  gatgtgcgc  gctcaggac  2520
cgagtccta  ctgtggagc  gcccccaca  tggctggct  tcccacaac  gtggccatc  2580
tgaagatgc  ggtgtcatc  gctcagttt  ccagtcccg  ccgacaccc  gtccagata  2640
ttggccgac  tcacatgca  caacagcag  acctgaatc  agcttggcc  tgaggctgg  2700
gaatggagg  gacaggtgt  agggccgag  ggaggtcct  taccgaggc  cctggggca  2760
cgtgtgtga  gatagctgg  acaccagtg  cgccaatgt  gtctgccgg  agctgggct  2820
tggctgggc  acgtcagcc  caggaaatg  ccggtttgg  cagggttca  gacccattg  2880
cctggatga  gtgcgctgc  caggctatg  gtcctacct  tggagctgc  cccacaatg  2940
ctggctctc  cataactgt  agcacagtg  agacgctgg  gtcatctgc  cagctgccc  3000
ctcctggtc  acgcccagt  cagacacat  gccgaccat  accttgcct  catcgacag  3060
aggatctga  tccagtttg  ccctgaggc  ggtgaatgg  ggtgacagg  gtcagggcc  3120
agtggaggt  ctataccaa  gctcctggg  caccgtgtg  gatgacagc  gggacacca  3180
tgatgccaa  gtcgtctgc  ggcaactgg  ctgtggctg  gccatgtca  ccccaggaa  3240
tgcccggtt  ggtcagggc  caggaccca  tgtcctgga  gatgcgcgc  gctcaggac  3300
cgagtctta  ctgtggagc  gcccccaca  tggctggct  tcccacaac  gtggccata  3360
tgaagacgc  ggtgtcatc  gctcagctt  ccagtcccg  ccaacacct  gtccagaca  3420
ttggccaac  tcacatgca  caacagcag  atctgaatc  agtttggcc  tgaggctgg  3480
gaatggagg  gacaggtgt  agggccgag  ggaggtcct  taccgaggc  cctggggca  3540
cgtgtgtga  gactactgg  acaccaatg  tgccaatgt  gcttgcagg  agctgggct  3600
tggctgggc  atgtcagcc  caggaaatg  ccggtttgg  cagggttca  gacccattg  3660
cctggatga  gtgcgctgc  caggacatg  gtcctatct  tggagctgc  cccacaatg  3720
ctggctctc  cacaactgt  gccatcatg  agacgctgg  gtcatctgc  cagcttccc  3780
gtcccagcc  acacccagc  cagacactt  gccaacctc  catgcatca  cagcaggat  3840
tgaatccag  ttggccctg  ggctggtga  tggaggtga  aggtgtcag  gccgagtgg  3900
ggtcctata  cgaggctcc  ggggcaccg  gtgtgatga  tactgggac  ccaatgatg  3960
caatgtggt  tgcaggcag  tgggctgtg  ctgggccac  tcagcccca  gaaatgccc  4020
gtttggcca  ggttcagga  ccattgtcc  ggatgatgt  cgctgctca  gacatgagt  4080
ctatctgtg  agctgcccc  acaatggct  gctctccca  aactgtggc  atcatgaag  4140
cgctggtgt  atctgctca  cttcccagt  ccagccgac  cccagccca  acacttggc  4200
aacctcaca  gcatcaaca  caggatctg  atccagttt  gccctgagg  tggtgaatg  4260
aggtgacag  tgtcagggc  gagtggagg  cctataccg  ggctcctgg  gcaccgtgt  4320
tgatgacta  tgggacacc  atgatgcca  tgtggtttg  aggcagctg  gctgtggct  4380
ggccacgtc  gccccagga  atgcccggt  tggccaggg  tcaggaccc  ttgtcctgg  4440
tgatgtgcg  tgctcagga  atgagtcct  tctgtggag  tgcccccac  atggctggc  4500
ctcccacaa  tgtggccat  atgaagacg  tggtgtcat  tgctcagct  tccagtccc  4560
gccgacacc  agcccagac  cttggccaa  ctctcgtgc  tcaacagca  gatctgaat  4620
cactttggc  ctgagactg  tgaatggag  tgacaggtg  cgaggccga  tggaggtcc  4680
ataccaagg  tcctggggc  ccgtgtgtg  tgactactg  gacaccaat  atgccaacg  4740
ggtctgcag  cagctgggc  gtggctggg  catgtcagc  ccaggaaat  cccagtttg  4800
ccagggctc  ggacccatt  tcctggatg  tgtgcgctg  tcaggacac  agccttacc  4860
gtggagctg  ccccacaat  gctggctct  ccacaactg  ggccatcat  aagatgctg  4920
tgtcatctg  tcagctgct  agtcccagt  aacgcccag  ccagatact  ggctgacca  4980
caacttacc  gcattgaca  taggatctg  atccagttt  gctctgagg  tggtgaatg  5040
aggtgacag  tgtcgaggc  gagtggagg  cctgtatcg  ggctcctgg  gaaccgtgt  5100
tgatgacag  tgggacacc  atgatgcca  tgtggtctg  aggcagctg  gctgtggct  5160
ggccatgtc  gccccagga  atgcccggt  tggccaggg  tcaggaccc  ttgtcctgg  5220
tgatgtgcg  tgctcaggg  atgagtcct  cctgtggag  tgcccccac  aaggctggc  5280
cacccacaa  tgtggccat  acgaagacg  tggtgtcat  tgctcagcc  cccaaataa  5340
ttctactac  acagattgg  ggcatccaa  aactacaac  actgcaaga  cctcttcaa  5400
ttgtggtgg  ttcttattc  atgccagtg  gacattctc  agcccatcc  accctgcat  5460
ctaccccaa  aatgctaag  gtgtttggg  aatagaagt  aattctggt  atcgcataa  5520
cctgggctt  agtaatctg  aattggagg  acaccataa  tgcagtttt  attatgttg  5580
aatctttga  ggatcattg  atagcagtc  cctgctggg  aaaatctgt  atgatacca  5640
gcaaatatt  acatcttct  acaaccgaa  gaccattca  tttcgaagt  acatcagtt  5700
ccaaaacac  ggctttttg  cttggtata  ctccttccc  agcgatgcc  ccttgaggt  5760
ggtcaattt  aattcatcc  atggtctat  tgccgggcg  gtagaaatt  accatggtg  5820
cacctgggg  gcagtttgt  atgactcct  gaccattca  gaagctgag  tggtctgca  5880
acagctagg  tgtggacgt  cagtttcag  ccttggaaa  gcatatttt  gctctggct  5940
tggccccat  accctggac  atgtagagt  ctcagggac  gaatccact  tctggcagt  6000
ccggaaccg  ggctggttc  cccacaact  taatcatcg  gaagatgct  gtgtcatct  6060
ctcaggaaa  catctatcg  cacctgctc  ttttctcaa  atcacccgt  caaacaact  6120
ttcctgcgg  ggcttccta  cccaaccat  aggggactt  tccagccca  tctatcccg  6180
gaactatcc  aacaatgcc  agtgtgtgt  ggacattga  gtgcaaaac  actaccgtg  6240
gactgtgat  ttcagagat  tccagcttg  aggtggctg  aactatgat  atattgaag  6300
tttcgatgg  ccctaccgc  gttcccctc  cattgctcg  gtttgtgat  gggccagag  6360
ctccttcac  tcttcctcc  acttcatgt  cattcgctt  atcagtgac  acagcatca  6420
aaggagagg  ttccgggct  agtactact  cagtccctc  aatgacagc  ccaacctgc  6480
ctgtctgcc  aatcacatg  aagccagtg  gagcaggag  tatctccaa  ccttgggct  6540
ttctgccag  gaccttgtc  tttccacct  gaatggata  tacgagtgt  ggccccaga  6600
aacgccgaa  ctggtgata  tcacaattc  ctactcagg  tgcggcacc  tcaagcagg  6660
agacaatga  accatcgac  attccaacc  cctcacagc  gctgtctca  gtggcatca  6720
caagaggag  acagacctc  gtattcacg  cagctgcag  atgcttcag  acacctggg  6780
cgacaccat  tacattgct  atgacacca  ccacgttgc  aataacacc  tccaggtcg  6840
ggaagtcca  tatggcaat  ttgacgtga  catttcctt  tatacttcc  catctttct  6900
gtatcctgt  accagccgc  cttactacg  ggacctgaa  caggacttg  acgttcagg  6960
tgaaatcct  cattctgat  ctgtactga  cttgtttgt  gacacctgc  tggcatcac  7020
atactccaa  gacttcacg  ctttgactt  tgatctaat  cggagtgga  gcgtgaggg  7080
tgacaccta  ggaccctac  cctcgccat  tcttcgcat  gcccgcttc  ggttcaggg  7140
cttccactt  ctgaaccgc  tcccctccg  gtacctgcg  tgtaaaatg  tggtgtgca  7200
agcgtatga  ccctcttcc  gctgctacc  aggctgtgt  ttgaggtcg  agagggatg  7260
gggctccta  caggaaaag  tggacgtcg  cctgggtcc  atccagctg  agacccccc  7320
acgccgaga  gaggagcct  ggtaggtgg  cgctctcag  ccccattgt  caccggggc  7380
cagacccct  actcgggga  ttgggatgt  cctcttggt  tcatattcc  actcagatt  7440
agccctaca  tgtgctgca  ctggtcata  ggagttgaa  cagacctgg  tcccgcctc  7500
cccaaggct  atggtcctt  gaggacccg  tgcagggtg  ggtcaagag  gttctgacc  7560
ggatggccc  tagacctga  gtcccagaa  ccatgcttc  catctgcaa  atgaaaatg  7620
caatactta  ttcttagca  tgttgagag  gttacttac  taaaggaat  ttggtgaaa  7680
tgc  7683



<210> 8378
<211> 2413
<212> PRT
<213> Homo sapiens
<308> AJ243212
<400> 8378

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
  1               5                  10                  15
Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
             20                  25                  30
Leu Ile Pro Ser Glu Val Pro Leu Asp Thr Thr Val Ala Glu Gly Ser 
         35                  40                  45
Pro Phe Pro Ser Glu Leu Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
     50                  55                  60
Pro Ile Ser Leu Glu Ser Thr Leu Glu Thr Thr Val Ala Glu Gly Ser 
 65                  70                  75                  80
Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                 85                  90                  95
Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
             100                105                110
Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Ala Val Cys Asp 
         115                120                125
Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
     130                135                140
Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
 145                150                155                160
Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                 165                170                175
Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
             180                185                190
His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
         195                200                205
Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
     210                215                220
Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
 225                230                235                240
Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                 245                250                255
Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
             260                265                270
Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
         275                280                285
Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
     290                295                300
Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
 305                310                315                320
His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                 325                330                335
Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
             340                345                350
Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
         355                360                365
Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
     370                375                380
Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
 385                390                395                400
Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                 405                410                415
Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
             420                425                430
Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
         435                440                445
Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
     450                455                460
Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr Ile Thr 
 465                470                475                480
Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu 
                 485                490                495
Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
             500                505                510
Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala 
         515                520                525
Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Leu Ala Pro 
     530                535                540
Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
 545                550                555                560
Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
                 565                570                575
Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile 
             580                585                590
Cys Ser Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
         595                600                605
Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
     610                615                620
Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
 625                630                635                640
Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Arg 
                 645                650                655
Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
             660                665                670
Gly His Glu Ser Tyr Leu Trp Ser Cys Pro Asn Asn Gly Trp Leu Ser 
         675                680                685
His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Ala 
     690                695                700
Gln Ser Arg Ser Thr Pro Arg Pro Asp Thr Leu Ser Thr Ile Thr Leu 
 705                710                715                720
Pro Pro Ser Thr Val Gly Ser Glu Ser Ser Leu Thr Leu Arg Leu Val 
                 725                730                735
Asn Gly Ser Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly 
             740                745                750
Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn 
         755                760                765
Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly 
     770                775                780
Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val 
 785                790                795                800
Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly 
                 805                810                815
Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys 
             820                825                830
Ser Val Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr 
         835                840                845
Ser His Ala Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu 
     850                855                860
Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
 865                870                875                880
Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala 
                 885                890                895
Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro 
             900                905                910
Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
         915                920                925
Val Arg Cys Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
     930                935                940
Gly Trp Leu Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile 
 945                950                955                960
Cys Ser Ala Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro 
                 965                970                975
Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala 
             980                985                990
Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val 
         995                1000                1005
Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr 
     1010                1015                1020
Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met 
 1025                1030                1035                1040
Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val 
                 1045                1050                1055
Leu Asp Asp Ala Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys 
             1060                1065                1070
Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala 
         1075                1080                1085
Gly Val Ile Cys Ser Ala Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp 
     1090                1095                1100
Thr Trp Pro Thr Ser His Ala Ser Thr Ala Gly Ser Glu Ser Ser Leu 
 1105                1110                1115                1120
Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu 
                 1125                1130                1135
Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp 
             1140                1145                1150
Thr Asn Asp Ala Asn Val Ala Cys Arg Gln Leu Gly Cys Gly Trp Ala 
         1155                1160                1165
Met Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile 
     1170                1175                1180
Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser 
 1185                1190                1195                1200
Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp 
                 1205                1210                1215
Ala Gly Val Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr Pro Ser Pro 
             1220                1225                1230
Asp Thr Trp Pro Thr Ser His Ala Ser Thr Ala Gly Ser Glu Ser Ser 
         1235                1240                1245
Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val 
     1250                1255                1260
Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp 
 1265                1270                1275                1280
Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp 
                 1285                1290                1295
Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro 
             1300                1305                1310
Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp 
         1315                1320                1325
Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu 
     1330                1335                1340
Asp Ala Gly Val Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr Pro Ser 
 1345                1350                1355                1360
Pro Asp Thr Trp Pro Thr Ser His Ala Ser Thr Ala Gly Ser Glu Ser 
                 1365                1370                1375
Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg 
             1380                1385                1390
Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr 
         1395                1400                1405
Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly 
     1410                1415                1420
Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly 
 1425                1430                1435                1440
Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu 
                 1445                1450                1455
Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His His 
             1460                1465                1470
Glu Asp Ala Gly Val Ile Cys Ser Ala Phe Gln Ser Gln Pro Thr Pro 
         1475                1480                1485
Ser Pro Asp Thr Trp Pro Thr Ser Arg Ala Ser Thr Ala Gly Ser Glu 
     1490                1495                1500
Ser Thr Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Arg Gly 
 1505                1510                1515                1520
Arg Val Glu Val Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp 
                 1525                1530                1535
Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys 
             1540                1545                1550
Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln Phe Gly Gln Gly Ser 
         1555                1560                1565
Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Pro Tyr 
     1570                1575                1580
Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His 
 1585                1590                1595                1600
His Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Ser Gln Ser Thr 
                 1605                1610                1615
Pro Arg Pro Asp Thr Trp Leu Thr Thr Asn Leu Pro Ala Leu Thr Val 
             1620                1625                1630
Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg 
         1635                1640                1645
Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val 
     1650                1655                1660
Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln 
 1665                1670                1675                1680
Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Arg Phe Gly 
                 1685                1690                1695
Gln Gly Ser Gly Pro Ile Val Leu Gly Asp Val Arg Cys Ser Gly Asn 
             1700                1705                1710
Glu Ser Tyr Leu Trp Ser Cys Pro His Lys Gly Trp Leu Thr His Asn 
         1715                1720                1725
Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Thr Gln Ile 
     1730                1735                1740
Asn Ser Thr Thr Thr Asp Trp Trp His Pro Thr Thr Thr Thr Thr Ala 
 1745                1750                1755                1760
Arg Pro Ser Ser Asn Cys Gly Gly Phe Leu Phe Tyr Ala Ser Gly Thr 
                 1765                1770                1775
Phe Ser Ser Pro Ser Tyr Pro Ala Tyr Tyr Pro Asn Asn Ala Lys Cys 
             1780                1785                1790
Val Trp Glu Ile Glu Val Asn Ser Gly Tyr Arg Ile Asn Leu Gly Phe 
         1795                1800                1805
Ser Asn Leu Lys Leu Glu Ala His His Asn Cys Ser Phe Asp Tyr Val 
     1810                1815                1820
Glu Ile Phe Asp Gly Ser Leu Asn Ser Ser Leu Leu Leu Gly Lys Ile 
 1825                1830                1835                1840
Cys Asn Asp Thr Arg Gln Ile Phe Thr Ser Ser Tyr Asn Arg Met Thr 
                 1845                1850                1855
Ile His Phe Arg Ser Asp Ile Ser Phe Gln Asn Thr Gly Phe Leu Ala 
             1860                1865                1870
Trp Tyr Asn Ser Phe Pro Ser Asp Ala Thr Leu Arg Leu Val Asn Leu 
         1875                1880                1885
Asn Ser Ser Tyr Gly Leu Cys Ala Gly Arg Val Glu Ile Tyr His Gly 
     1890                1895                1900
Gly Thr Trp Gly Ala Val Cys Asp Asp Ser Trp Thr Ile Gln Glu Ala 
 1905                1910                1915                1920
Glu Val Val Cys Arg Gln Leu Gly Cys Gly Arg Ala Val Ser Ala Leu 
                 1925                1930                1935
Gly Asn Ala Tyr Phe Gly Ser Gly Ser Gly Pro Ile Thr Leu Asp Asp 
             1940                1945                1950
Val Glu Cys Ser Gly Thr Glu Ser Thr Leu Trp Gln Cys Arg Asn Arg 
         1955                1960                1965
Gly Trp Phe Ser His Asn Cys Asn His Arg Glu Asp Ala Gly Val Ile 
     1970                1975                1980
Cys Ser Gly Asn His Leu Ser Thr Pro Ala Pro Phe Leu Asn Ile Thr 
 1985                1990                1995                2000
Arg Pro Asn Asn Tyr Ser Cys Gly Gly Phe Leu Ser Gln Pro Ser Gly 
                 2005                2010                2015
Asp Phe Ser Ser Pro Phe Tyr Pro Gly Asn Tyr Pro Asn Asn Ala Lys 
             2020                2025                2030
Cys Val Trp Asp Ile Glu Val Gln Asn Asn Tyr Arg Val Thr Val Ile 
         2035                2040                2045
Phe Arg Asp Val Gln Leu Glu Gly Gly Cys Asn Tyr Asp Tyr Ile Glu 
     2050                2055                2060
Val Phe Asp Gly Pro Tyr Arg Ser Ser Pro Leu Ile Ala Arg Val Cys 
 2065                2070                2075                2080
Asp Gly Ala Arg Gly Ser Phe Thr Ser Ser Ser Asn Phe Met Ser Ile 
                 2085                2090                2095
Arg Phe Ile Ser Asp His Ser Ile Thr Arg Arg Gly Phe Arg Ala Glu 
             2100                2105                2110
Tyr Tyr Ser Ser Pro Ser Asn Asp Ser Thr Asn Leu Leu Cys Leu Pro 
         2115                2120                2125
Asn His Met Gln Ala Ser Val Ser Arg Ser Tyr Leu Gln Ser Leu Gly 
     2130                2135                2140
Phe Ser Ala Ser Asp Leu Val Ile Ser Thr Trp Asn Gly Tyr Tyr Glu 
 2145                2150                2155                2160
Cys Arg Pro Gln Ile Thr Pro Asn Leu Val Ile Phe Thr Ile Pro Tyr 
                 2165                2170                2175
Ser Gly Cys Gly Thr Phe Lys Gln Ala Asp Asn Asp Thr Ile Asp Tyr 
             2180                2185                2190
Ser Asn Leu Leu Thr Ala Ala Val Ser Gly Gly Ile Ile Lys Arg Arg 
         2195                2200                2205
Thr Asp Leu Arg Ile His Val Ser Cys Arg Met Leu Gln Asn Thr Trp 
     2210                2215                2220
Val Asp Thr Met Tyr Ile Ala Asn Asp Thr Ile His Val Ala Asn Asn 
 2225                2230                2235                2240
Thr Ile Gln Val Glu Glu Val Gln Tyr Gly Asn Phe Asp Val Asn Ile 
                 2245                2250                2255
Ser Phe Tyr Thr Ser Ser Ser Phe Leu Tyr Pro Val Thr Ser Arg Pro 
             2260                2265                2270
Tyr Tyr Val Asp Leu Asn Gln Asp Leu Tyr Val Gln Ala Glu Ile Leu 
         2275                2280                2285
His Ser Asp Ala Val Leu Thr Leu Phe Val Asp Thr Cys Val Ala Ser 
     2290                2295                2300
Pro Tyr Ser Asn Asp Phe Thr Ser Leu Thr Tyr Asp Leu Ile Arg Ser 
 2305                2310                2315                2320
Gly Cys Val Arg Asp Asp Thr Tyr Gly Pro Tyr Ser Ser Pro Ser Leu 
                 2325                2330                2335
Arg Ile Ala Arg Phe Arg Phe Arg Ala Phe His Phe Leu Asn Arg Phe 
             2340                2345                2350
Pro Ser Val Tyr Leu Arg Cys Lys Met Val Val Cys Arg Ala Tyr Asp 
         2355                2360                2365
Pro Ser Ser Arg Cys Tyr Arg Gly Cys Val Leu Arg Ser Lys Arg Asp 
     2370                2375                2380
Val Gly Ser Tyr Gln Glu Lys Val Asp Val Val Leu Gly Pro Ile Gln 
 2385                2390                2395                2400
Leu Gln Thr Pro Pro Arg Arg Glu Glu Glu Pro Arg Ter 
                 2405                2410



<210> 8379
<211> 2107
<212> DNA
<213> Rattus norvegicus
<308> U33553
<400> 8379

gggctccgc  caatgggcc  agctggagg  gggggcccg  gctgggggc  gccgccagt  60
ctgctgctt  tgggggtca  gctggtgct  accgctggg  ctgtaccgg  acgggaagc  120
ggcagtgcg  tcgaggctg  agagctggt  aggagcggc  ttgcatggg  gtcgcgtgc  180
aatgacacg  gggaggaag  tggcctgcc  gcagcaggg  aagatgaga  ctcgtggac  240
gagcggggc  gtgagctgg  tgcggtggg  cctggggtc  ggccagagg  gacactaga  300
gcatcggct  cagtgactg  gactgcctg  ctagaggca  atggcacag  cctgggtgg  360
gtgactgca  aggctggta  tggcgacgc  cagaccctt  cagctacac  ccaggctcc  420
gacgaggcc  ttgggtcat  tacaatgcc  cctgccatc  ctgaggcta  tgaagccag  480
ggacctccc  cccccaccc  ccgtgataa  cctagccta  tccctgaac  ccctaagga  540
atccccttg  aagtttggc  gaacctggg  ggcagcaca  ctgaccctc  aaggccaga  600
cctactttt  cccttcagg  cactctaga  acacaacca  cctcagata  aattgacat  660
gattacttt  aaggattgg  tagcgaggg  cgaggcaca  acatgggca  gttcccggg  720
tcaccagga  cctcagaaa  tcaccctga  actgaagga  agaccccct  ctggagcct  780
cttgactta  atgatgact  caccccctt  gatgagtct  atttctacc  caccacatc  840
ttctatgat  acttggaag  ggaggaaga  gaggaggag  ataaggatg  agtgggagg  900
ggagacctg  aagatgaaa  tgacctcct  ctgccctct  agaagcctg  tgtggggcc  960
gggacggga  agcccacca  tcgatggca  gcagttcct  cacagcata  tctggggat  1020
gtacctggt  gcagcatct  tcttaggcc  cgccctgga  atccaggca  ggacctggc  1080
acgagcgaa  atggaacag  gtgccgagt  ggctttgtc  gacacaatg  ctcctgtcg  1140
tcagtctgt  acctcttcc  gagttactg  cacaatggc  gccaatgct  cctggtgga  1200
aacataggg  ctttctgca  gtgtaacac  caggactat  tctggcaca  ggggatgcg  1260
tgtgagtcc  tcatcaccg  cttccaggt  atgtgcgtg  ccgtcggct  ggctgcgtt  1320
gtgctgctc  ttctgttca  gatgactgt  ttctttgcc  agaaactct  tctgctcaa  1380
actgagaac  ccaagctga  gaggaccaa  aaattccgg  ccccatctg  gctccacaa  1440
gataacttc  ccctctcca  cattgccga  ggctcccat  caaatgatg  ccccagcgc  1500
ccccacaaa  tccaggaag  tctcaagtc  cgcctgaag  aggaagagt  ctttaacat  1560
cagaactcc  tgtcaccca  actcgaggg  ggcaaaggt  accaggatg  cttggaggt  1620
aactttctc  agaataacc  gacctgaga  ggaggaggg  gaggggaga  gggggtggg  1680
gagggaagg  ccgtggtct  ctctcgggc  gccggctcc  cataaccat  tgttaagct  1740
ttcctttgc  gatctcatg  catgctctg  tgtgttttg  aggaggggg  aactcttaa  1800
ataagcaaa  aaaccgagc  gggttgcgt  cattggatg  ttctcgtct  tgctctttg  1860
acgttgctt  tacagctgt  atttctaag  ctatgctgg  actcagctg  cttgttttt  1920
tggtttttt  gtttttgtt  tttctgggt  tttgttttg  tttgttttg  tttgtttct  1980
tgttttttg  tttggtttt  ttttgtttg  ttgtttttg  ttttttgta  tttgaccca  2040
ctttttttg  aataccagt  taaaaaaac  aaacaaaca  ggttcttga  ataaaactt  2100
ttaaaaa  2107



<210> 8380
<211> 544
<212> PRT
<213> Rattus norvegicus
<308> AAC98537
<400> 8380

Met Gly Arg Ala Gly Gly Gly Gly Pro Gly Trp Gly Pro Pro Pro Val 
  1               5                  10                  15
Leu Leu Leu Leu Gly Val Thr Leu Val Leu Thr Ala Gly Ala Val Pro 
             20                  25                  30
Ala Arg Glu Ala Gly Ser Ala Ile Glu Ala Glu Glu Leu Val Arg Ser 
         35                  40                  45
Gly Leu Ala Trp Glu Ser Arg Ala Asn Asp Thr Arg Glu Glu Ala Gly 
     50                  55                  60
Leu Pro Ala Ala Gly Glu Asp Glu Thr Ser Trp Thr Glu Arg Gly Ser 
 65                  70                  75                  80
Glu Leu Ala Ala Val Gly Pro Gly Val Gly Pro Glu Glu Thr Leu Glu 
                 85                  90                  95
Ala Ser Ala Ala Val Thr Gly Thr Ala Trp Leu Glu Ala Asp Gly Thr 
             100                105                110
Gly Leu Gly Gly Val Thr Ala Glu Ala Gly Ser Gly Asp Ala Gln Thr 
         115                120                125
Leu Pro Ala Thr Leu Gln Ala Pro Asp Glu Ala Leu Gly Ser Ser Thr 
     130                135                140
Met Pro Pro Ala Ile Pro Glu Ala Thr Glu Ala Ser Gly Pro Pro Ser 
 145                150                155                160
Pro Thr Leu Arg Asp Lys Pro Ser Leu Val Pro Glu Leu Pro Lys Glu 
                 165                170                175
Ile Pro Leu Glu Val Trp Leu Asn Leu Gly Gly Ser Thr Pro Asp Pro 
             180                185                190
Gln Arg Pro Glu Pro Thr Phe Pro Leu Gln Gly Thr Leu Glu Thr Gln 
         195                200                205
Pro Ala Ser Asp Ile Ile Asp Ile Asp Tyr Phe Glu Gly Leu Asp Ser 
     210                215                220
Glu Gly Arg Gly Thr Asp Met Gly Arg Phe Pro Gly Ser Pro Gly Thr 
 225                230                235                240
Ser Glu Asn His Pro Asp Thr Glu Gly Glu Thr Pro Ser Trp Ser Leu 
                 245                250                255
Leu Asp Leu Tyr Asp Asp Phe Thr Pro Phe Asp Glu Ser Asp Phe Tyr 
             260                265                270
Pro Thr Thr Ser Phe Tyr Asp Asp Leu Glu Glu Glu Glu Glu Glu Glu 
         275                280                285
Glu Asp Lys Asp Ala Val Gly Gly Gly Asp Leu Glu Asp Glu Ser Asp 
     290                295                300
Leu Leu Leu Pro Ser Gln Lys Pro Gly Val Gly Pro Gly Thr Gly Gln 
 305                310                315                320
Pro Thr Ser Arg Trp His Ala Val Pro Pro Gln His Thr Leu Gly Met 
                 325                330                335
Val Pro Gly Gly Ser Ile Ser Leu Arg Pro Arg Pro Gly Asp Pro Gly 
             340                345                350
Lys Asp Leu Ala Thr Ser Glu Asn Gly Thr Glu Cys Arg Val Gly Phe 
         355                360                365
Val Arg His Asn Gly Ser Cys Arg Ser Val Cys Asp Leu Phe Pro Ser 
     370                375                380
Tyr Cys His Asn Gly Gly Gln Cys Tyr Leu Val Glu Asn Ile Gly Ala 
 385                390                395                400
Phe Cys Arg Cys Asn Thr Gln Asp Tyr Ile Trp His Lys Gly Met Arg 
                 405                410                415
Cys Glu Ser Ile Ile Thr Asp Phe Gln Val Met Cys Val Ala Val Gly 
             420                425                430
Ser Ala Ala Leu Val Leu Leu Leu Leu Phe Met Met Thr Val Phe Phe 
         435                440                445
Ala Lys Lys Leu Tyr Leu Leu Lys Thr Glu Asn Thr Lys Leu Arg Arg 
     450                455                460
Thr Asn Lys Phe Arg Thr Pro Ser Glu Leu His Asn Asp Asn Phe Ser 
 465                470                475                480
Leu Ser Thr Ile Ala Glu Gly Ser His Pro Asn Asp Asp Pro Ser Ala 
                 485                490                495
Pro His Lys Ile Gln Glu Ala Leu Lys Ser Arg Leu Lys Glu Glu Glu 
             500                505                510
Ser Phe Asn Ile Gln Asn Ser Met Ser Pro Lys Leu Glu Gly Gly Lys 
         515                520                525
Gly Asp Gln Asp Asp Leu Glu Val Asn Phe Leu Gln Asn Asn Leu Thr 
     530                535                540



<210> 8381
<211> 1728
<212> DNA
<213> Homo sapiens
<308> AF059274
<400> 8381

agcgccatg  ggcgagccg  gggcggggg  ccgggccgg  ggccgccgc  actgctgct  60
tttctgggg  ccgcgctgg  cctggcctc  ggggccgtg  cggcgcgtg  ggcgggcag  120
gcggttgag  ccgaagagc  ggtgaaggg  agcccggcg  gggagccgc  tgccaacga  180
acgcgggaa  aagccggcc  accagcggc  ggggaagat  aggcgtcgt  gacggcgcc  240
ggtggcgag  tggccgggc  agaagaggt  ctgcaggag  cggctgcgg  gaccggcac  300
gcctggctg  aagctgaca  cccaggcct  ggaggagtg  ccgcagagg  gggcagcgg  360
gatgcccag  cccttccag  tacgctcca  gctccccac  aggtcctcg  gcagtcaat  420
atgccccct  ccattcctg  ggctacaga  gccagcggg  caccctccc  cacccccgg  480
gacaagctg  gcccagctt  tgaactccc  aaggagagc  ccttggagg  ttggctgaa  540
ctggggggc  gcacacccg  ccctcaagt  ccagagctg  cttacccat  tcagggcac  600
ctggagccc  aaccggcat  agatatcat  gacatcgac  acttcgaag  actggatgg  660
gagggtcgt  gcgcagatc  ggggagctt  ccagggtca  caggaacct  agagaacca  720
cctgatact  agggagaga  cccttcctg  agcctgctt  acttatacg  tgatttcac  780
cccttcgat  aatctgatt  ctaccccac  acatccttt  atgatgact  ggatgaaga  840
gaggaggaa  aggaggatg  caaagatgc  gtaggaggt  gagacctag  agatgaaaa  900
gagcttcta  tgcccactg  gaagcctgg  ctggggccc  ggacaggcc  gcccaccag  960
cggtggcat  ctgtccctc  acagcacac  ctggggtcg  tccccggca  cagcatcgc  1020
ctcaggccc  gcccaggag  gccaggcag  gacttggcc  ccagtgaaa  tggcactga  1080
tgccgcagt  gctttgtgc  gcataacgg  tcctgccgg  cagtgtgcg  cctcttccc  1140
agttactgt  acaatggcg  ccagtgcta  ctggtggag  acatagggg  cttctgcag  1200
tgcaacacg  aggactaca  ctggcacaa  gggatgcgc  gcgagtcca  catcaccga  1260
ttccaggtg  tgtgcgtgg  cgtgggctc  gctgccctc  tcctgctcc  gctcttcat  1320
atgacggtg  tctttgcca  gaagctcta  ctgctcaag  cggagaata  caagctgcg  1380
aggaccaac  aattccgga  cccatctga  ctccacaat  ataacttct  cctctccac  1440
attgccgag  gctctcacc  aaatgatga  cctagtgct  cccacaaaa  ccaggaggt  1500
ctcaagtcc  gcctgaaag  ggaggagtc  tttaacatc  agaactcca  gtcgcccaa  1560
cttgagggt  gcaaaggtg  ccaggctga  ttggatgtg  actgtcttc  gaataattt  1620
acctaaagc  gagcaagaa  agaggaagc  gggtagtgg  tgggggtag  gaagaaaca  1680
tatctcctc  tgtacagag  ctatttctt  taaccattt  ttaaactc  1728



<210> 8382
<211> 539
<212> PRT
<213> Homo sapiens
<308> AAC69612
<400> 8382

Met Gly Arg Ala Gly Gly Gly Gly Pro Gly Arg Gly Pro Pro Pro Leu 
  1               5                  10                  15
Leu Leu Phe Leu Gly Ala Ala Leu Val Leu Ala Ser Gly Ala Val Pro 
             20                  25                  30
Ala Arg Glu Ala Gly Ser Ala Val Glu Ala Glu Glu Leu Val Lys Gly 
         35                  40                  45
Ser Pro Ala Trp Glu Pro Pro Ala Asn Asp Thr Arg Glu Glu Ala Gly 
     50                  55                  60
Pro Pro Ala Ala Gly Glu Asp Glu Ala Ser Trp Thr Ala Pro Gly Gly 
 65                  70                  75                  80
Glu Leu Ala Gly Pro Glu Glu Val Leu Gln Glu Ser Ala Ala Val Thr 
                 85                  90                  95
Gly Thr Ala Trp Leu Glu Ala Asp Ser Pro Gly Leu Gly Gly Val Thr 
             100                105                110
Ala Glu Ala Gly Ser Gly Asp Ala Gln Ala Leu Pro Ala Thr Leu Gln 
         115                120                125
Ala Pro His Glu Val Leu Gly Gln Ser Ile Met Pro Pro Ala Ile Pro 
     130                135                140
Glu Ala Thr Glu Ala Ser Gly Pro Pro Ser Pro Thr Pro Gly Asp Lys 
 145                150                155                160
Leu Ser Pro Ala Ser Glu Leu Pro Lys Glu Ser Pro Leu Glu Val Trp 
                 165                170                175
Leu Asn Leu Gly Gly Ser Thr Pro Asp Pro Gln Val Pro Glu Leu Thr 
             180                185                190
Tyr Pro Phe Gln Gly Thr Leu Glu Pro Gln Pro Ala Ser Asp Ile Ile 
         195                200                205
Asp Ile Asp Tyr Phe Glu Gly Leu Asp Gly Glu Gly Arg Gly Ala Asp 
     210                215                220
Leu Gly Ser Phe Pro Gly Ser Pro Gly Thr Ser Glu Asn His Pro Asp 
 225                230                235                240
Thr Glu Gly Glu Thr Pro Ser Trp Ser Leu Leu Asp Leu Tyr Asp Asp 
                 245                250                255
Phe Thr Pro Phe Asp Glu Ser Asp Phe Tyr Pro Thr Thr Ser Phe Tyr 
             260                265                270
Asp Asp Leu Asp Glu Glu Glu Glu Glu Glu Glu Asp Asp Lys Asp Ala 
         275                280                285
Val Gly Gly Gly Asp Leu Glu Asp Glu Asn Glu Leu Leu Val Pro Thr 
     290                295                300
Gly Lys Pro Gly Leu Gly Pro Gly Thr Gly Gln Pro Thr Ser Arg Trp 
 305                310                315                320
His Ala Val Pro Pro Gln His Thr Leu Gly Ser Val Pro Gly Ser Ser 
                 325                330                335
Ile Ala Leu Arg Pro Arg Pro Gly Glu Pro Gly Arg Asp Leu Ala Ser 
             340                345                350
Ser Glu Asn Gly Thr Glu Cys Arg Ser Gly Phe Val Arg His Asn Gly 
         355                360                365
Ser Cys Arg Ser Val Cys Asp Leu Phe Pro Ser Tyr Cys His Asn Gly 
     370                375                380
Gly Gln Cys Tyr Leu Val Glu Asn Ile Gly Ala Phe Cys Arg Cys Asn 
 385                390                395                400
Thr Gln Asp Tyr Ile Trp His Lys Gly Met Arg Cys Glu Ser Ile Ile 
                 405                410                415
Thr Asp Phe Gln Val Met Cys Val Ala Val Gly Ser Ala Ala Leu Val 
             420                425                430
Leu Leu Leu Leu Phe Met Met Thr Val Phe Phe Ala Lys Lys Leu Tyr 
         435                440                445
Leu Leu Lys Thr Glu Asn Thr Lys Leu Arg Arg Thr Asn Lys Phe Arg 
     450                455                460
Thr Pro Ser Glu Leu His Asn Asp Asn Phe Ser Leu Ser Thr Ile Ala 
 465                470                475                480
Glu Gly Ser His Pro Asn Asp Asp Pro Ser Ala Pro His Lys Ile Gln 
                 485                490                495
Glu Val Leu Lys Ser Cys Leu Lys Glu Glu Glu Ser Phe Asn Ile Gln 
             500                505                510
Asn Ser Met Ser Pro Lys Leu Glu Gly Gly Lys Gly Asp Gln Ala Asp 
         515                520                525
Leu Asp Val Asn Cys Leu Gln Asn Asn Leu Thr 
     530                535



<210> 8383
<211> 2107
<212> DNA
<213> Rattus norvegicus
<308> U33553
<400> 8383

gggctccgc  caatgggcc  agctggagg  gggggcccg  gctgggggc  gccgccagt  60
ctgctgctt  tgggggtca  gctggtgct  accgctggg  ctgtaccgg  acgggaagc  120
ggcagtgcg  tcgaggctg  agagctggt  aggagcggc  ttgcatggg  gtcgcgtgc  180
aatgacacg  gggaggaag  tggcctgcc  gcagcaggg  aagatgaga  ctcgtggac  240
gagcggggc  gtgagctgg  tgcggtggg  cctggggtc  ggccagagg  gacactaga  300
gcatcggct  cagtgactg  gactgcctg  ctagaggca  atggcacag  cctgggtgg  360
gtgactgca  aggctggta  tggcgacgc  cagaccctt  cagctacac  ccaggctcc  420
gacgaggcc  ttgggtcat  tacaatgcc  cctgccatc  ctgaggcta  tgaagccag  480
ggacctccc  cccccaccc  ccgtgataa  cctagccta  tccctgaac  ccctaagga  540
atccccttg  aagtttggc  gaacctggg  ggcagcaca  ctgaccctc  aaggccaga  600
cctactttt  cccttcagg  cactctaga  acacaacca  cctcagata  aattgacat  660
gattacttt  aaggattgg  tagcgaggg  cgaggcaca  acatgggca  gttcccggg  720
tcaccagga  cctcagaaa  tcaccctga  actgaagga  agaccccct  ctggagcct  780
cttgactta  atgatgact  caccccctt  gatgagtct  atttctacc  caccacatc  840
ttctatgat  acttggaag  ggaggaaga  gaggaggag  ataaggatg  agtgggagg  900
ggagacctg  aagatgaaa  tgacctcct  ctgccctct  agaagcctg  tgtggggcc  960
gggacggga  agcccacca  tcgatggca  gcagttcct  cacagcata  tctggggat  1020
gtacctggt  gcagcatct  tcttaggcc  cgccctgga  atccaggca  ggacctggc  1080
acgagcgaa  atggaacag  gtgccgagt  ggctttgtc  gacacaatg  ctcctgtcg  1140
tcagtctgt  acctcttcc  gagttactg  cacaatggc  gccaatgct  cctggtgga  1200
aacataggg  ctttctgca  gtgtaacac  caggactat  tctggcaca  ggggatgcg  1260
tgtgagtcc  tcatcaccg  cttccaggt  atgtgcgtg  ccgtcggct  ggctgcgtt  1320
gtgctgctc  ttctgttca  gatgactgt  ttctttgcc  agaaactct  tctgctcaa  1380
actgagaac  ccaagctga  gaggaccaa  aaattccgg  ccccatctg  gctccacaa  1440
gataacttc  ccctctcca  cattgccga  ggctcccat  caaatgatg  ccccagcgc  1500
ccccacaaa  tccaggaag  tctcaagtc  cgcctgaag  aggaagagt  ctttaacat  1560
cagaactcc  tgtcaccca  actcgaggg  ggcaaaggt  accaggatg  cttggaggt  1620
aactttctc  agaataacc  gacctgaga  ggaggaggg  gaggggaga  gggggtggg  1680
gagggaagg  ccgtggtct  ctctcgggc  gccggctcc  cataaccat  tgttaagct  1740
ttcctttgc  gatctcatg  catgctctg  tgtgttttg  aggaggggg  aactcttaa  1800
ataagcaaa  aaaccgagc  gggttgcgt  cattggatg  ttctcgtct  tgctctttg  1860
acgttgctt  tacagctgt  atttctaag  ctatgctgg  actcagctg  cttgttttt  1920
tggtttttt  gtttttgtt  tttctgggt  tttgttttg  tttgttttg  tttgtttct  1980
tgttttttg  tttggtttt  ttttgtttg  ttgtttttg  ttttttgta  tttgaccca  2040
ctttttttg  aataccagt  taaaaaaac  aaacaaaca  ggttcttga  ataaaactt  2100
ttaaaaa  2107



<210> 8384
<211> 544
<212> PRT
<213> Rattus norvegicus
<308> NP_062157
<400> 8384

Met Gly Arg Ala Gly Gly Gly Gly Pro Gly Trp Gly Pro Pro Pro Val 
  1               5                  10                  15
Leu Leu Leu Leu Gly Val Thr Leu Val Leu Thr Ala Gly Ala Val Pro 
             20                  25                  30
Ala Arg Glu Ala Gly Ser Ala Ile Glu Ala Glu Glu Leu Val Arg Ser 
         35                  40                  45
Gly Leu Ala Trp Glu Ser Arg Ala Asn Asp Thr Arg Glu Glu Ala Gly 
     50                  55                  60
Leu Pro Ala Ala Gly Glu Asp Glu Thr Ser Trp Thr Glu Arg Gly Ser 
 65                  70                  75                  80
Glu Leu Ala Ala Val Gly Pro Gly Val Gly Pro Glu Glu Thr Leu Glu 
                 85                  90                  95
Ala Ser Ala Ala Val Thr Gly Thr Ala Trp Leu Glu Ala Asp Gly Thr 
             100                105                110
Gly Leu Gly Gly Val Thr Ala Glu Ala Gly Ser Gly Asp Ala Gln Thr 
         115                120                125
Leu Pro Ala Thr Leu Gln Ala Pro Asp Glu Ala Leu Gly Ser Ser Thr 
     130                135                140
Met Pro Pro Ala Ile Pro Glu Ala Thr Glu Ala Ser Gly Pro Pro Ser 
 145                150                155                160
Pro Thr Leu Arg Asp Lys Pro Ser Leu Val Pro Glu Leu Pro Lys Glu 
                 165                170                175
Ile Pro Leu Glu Val Trp Leu Asn Leu Gly Gly Ser Thr Pro Asp Pro 
             180                185                190
Gln Arg Pro Glu Pro Thr Phe Pro Leu Gln Gly Thr Leu Glu Thr Gln 
         195                200                205
Pro Ala Ser Asp Ile Ile Asp Ile Asp Tyr Phe Glu Gly Leu Asp Ser 
     210                215                220
Glu Gly Arg Gly Thr Asp Met Gly Arg Phe Pro Gly Ser Pro Gly Thr 
 225                230                235                240
Ser Glu Asn His Pro Asp Thr Glu Gly Glu Thr Pro Ser Trp Ser Leu 
                 245                250                255
Leu Asp Leu Tyr Asp Asp Phe Thr Pro Phe Asp Glu Ser Asp Phe Tyr 
             260                265                270
Pro Thr Thr Ser Phe Tyr Asp Asp Leu Glu Glu Glu Glu Glu Glu Glu 
         275                280                285
Glu Asp Lys Asp Ala Val Gly Gly Gly Asp Leu Glu Asp Glu Ser Asp 
     290                295                300
Leu Leu Leu Pro Ser Gln Lys Pro Gly Val Gly Pro Gly Thr Gly Gln 
 305                310                315                320
Pro Thr Ser Arg Trp His Ala Val Pro Pro Gln His Thr Leu Gly Met 
                 325                330                335
Val Pro Gly Gly Ser Ile Ser Leu Arg Pro Arg Pro Gly Asp Pro Gly 
             340                345                350
Lys Asp Leu Ala Thr Ser Glu Asn Gly Thr Glu Cys Arg Val Gly Phe 
         355                360                365
Val Arg His Asn Gly Ser Cys Arg Ser Val Cys Asp Leu Phe Pro Ser 
     370                375                380
Tyr Cys His Asn Gly Gly Gln Cys Tyr Leu Val Glu Asn Ile Gly Ala 
 385                390                395                400
Phe Cys Arg Cys Asn Thr Gln Asp Tyr Ile Trp His Lys Gly Met Arg 
                 405                410                415
Cys Glu Ser Ile Ile Thr Asp Phe Gln Val Met Cys Val Ala Val Gly 
             420                425                430
Ser Ala Ala Leu Val Leu Leu Leu Leu Phe Met Met Thr Val Phe Phe 
         435                440                445
Ala Lys Lys Leu Tyr Leu Leu Lys Thr Glu Asn Thr Lys Leu Arg Arg 
     450                455                460
Thr Asn Lys Phe Arg Thr Pro Ser Glu Leu His Asn Asp Asn Phe Ser 
 465                470                475                480
Leu Ser Thr Ile Ala Glu Gly Ser His Pro Asn Asp Asp Pro Ser Ala 
                 485                490                495
Pro His Lys Ile Gln Glu Ala Leu Lys Ser Arg Leu Lys Glu Glu Glu 
             500                505                510
Ser Phe Asn Ile Gln Asn Ser Met Ser Pro Lys Leu Glu Gly Gly Lys 
         515                520                525
Gly Asp Gln Asp Asp Leu Glu Val Asn Phe Leu Gln Asn Asn Leu Thr 
     530                535                540



<210> 8385
<211> 1728
<212> DNA
<213> Homo sapiens
<308> AF059274
<400> 8385

agcgccatg  ggcgagccg  gggcggggg  ccgggccgg  ggccgccgc  actgctgct  60
tttctgggg  ccgcgctgg  cctggcctc  ggggccgtg  cggcgcgtg  ggcgggcag  120
gcggttgag  ccgaagagc  ggtgaaggg  agcccggcg  gggagccgc  tgccaacga  180
acgcgggaa  aagccggcc  accagcggc  ggggaagat  aggcgtcgt  gacggcgcc  240
ggtggcgag  tggccgggc  agaagaggt  ctgcaggag  cggctgcgg  gaccggcac  300
gcctggctg  aagctgaca  cccaggcct  ggaggagtg  ccgcagagg  gggcagcgg  360
gatgcccag  cccttccag  tacgctcca  gctccccac  aggtcctcg  gcagtcaat  420
atgccccct  ccattcctg  ggctacaga  gccagcggg  caccctccc  cacccccgg  480
gacaagctg  gcccagctt  tgaactccc  aaggagagc  ccttggagg  ttggctgaa  540
ctggggggc  gcacacccg  ccctcaagt  ccagagctg  cttacccat  tcagggcac  600
ctggagccc  aaccggcat  agatatcat  gacatcgac  acttcgaag  actggatgg  660
gagggtcgt  gcgcagatc  ggggagctt  ccagggtca  caggaacct  agagaacca  720
cctgatact  agggagaga  cccttcctg  agcctgctt  acttatacg  tgatttcac  780
cccttcgat  aatctgatt  ctaccccac  acatccttt  atgatgact  ggatgaaga  840
gaggaggaa  aggaggatg  caaagatgc  gtaggaggt  gagacctag  agatgaaaa  900
gagcttcta  tgcccactg  gaagcctgg  ctggggccc  ggacaggcc  gcccaccag  960
cggtggcat  ctgtccctc  acagcacac  ctggggtcg  tccccggca  cagcatcgc  1020
ctcaggccc  gcccaggag  gccaggcag  gacttggcc  ccagtgaaa  tggcactga  1080
tgccgcagt  gctttgtgc  gcataacgg  tcctgccgg  cagtgtgcg  cctcttccc  1140
agttactgt  acaatggcg  ccagtgcta  ctggtggag  acatagggg  cttctgcag  1200
tgcaacacg  aggactaca  ctggcacaa  gggatgcgc  gcgagtcca  catcaccga  1260
ttccaggtg  tgtgcgtgg  cgtgggctc  gctgccctc  tcctgctcc  gctcttcat  1320
atgacggtg  tctttgcca  gaagctcta  ctgctcaag  cggagaata  caagctgcg  1380
aggaccaac  aattccgga  cccatctga  ctccacaat  ataacttct  cctctccac  1440
attgccgag  gctctcacc  aaatgatga  cctagtgct  cccacaaaa  ccaggaggt  1500
ctcaagtcc  gcctgaaag  ggaggagtc  tttaacatc  agaactcca  gtcgcccaa  1560
cttgagggt  gcaaaggtg  ccaggctga  ttggatgtg  actgtcttc  gaataattt  1620
acctaaagc  gagcaagaa  agaggaagc  gggtagtgg  tgggggtag  gaagaaaca  1680
tatctcctc  tgtacagag  ctatttctt  taaccattt  ttaaactc  1728



<210> 8386
<211> 539
<212> PRT
<213> Homo sapiens
<308> NP_006565
<400> 8386

Met Gly Arg Ala Gly Gly Gly Gly Pro Gly Arg Gly Pro Pro Pro Leu 
  1               5                  10                  15
Leu Leu Phe Leu Gly Ala Ala Leu Val Leu Ala Ser Gly Ala Val Pro 
             20                  25                  30
Ala Arg Glu Ala Gly Ser Ala Val Glu Ala Glu Glu Leu Val Lys Gly 
         35                  40                  45
Ser Pro Ala Trp Glu Pro Pro Ala Asn Asp Thr Arg Glu Glu Ala Gly 
     50                  55                  60
Pro Pro Ala Ala Gly Glu Asp Glu Ala Ser Trp Thr Ala Pro Gly Gly 
 65                  70                  75                  80
Glu Leu Ala Gly Pro Glu Glu Val Leu Gln Glu Ser Ala Ala Val Thr 
                 85                  90                  95
Gly Thr Ala Trp Leu Glu Ala Asp Ser Pro Gly Leu Gly Gly Val Thr 
             100                105                110
Ala Glu Ala Gly Ser Gly Asp Ala Gln Ala Leu Pro Ala Thr Leu Gln 
         115                120                125
Ala Pro His Glu Val Leu Gly Gln Ser Ile Met Pro Pro Ala Ile Pro 
     130                135                140
Glu Ala Thr Glu Ala Ser Gly Pro Pro Ser Pro Thr Pro Gly Asp Lys 
 145                150                155                160
Leu Ser Pro Ala Ser Glu Leu Pro Lys Glu Ser Pro Leu Glu Val Trp 
                 165                170                175
Leu Asn Leu Gly Gly Ser Thr Pro Asp Pro Gln Val Pro Glu Leu Thr 
             180                185                190
Tyr Pro Phe Gln Gly Thr Leu Glu Pro Gln Pro Ala Ser Asp Ile Ile 
         195                200                205
Asp Ile Asp Tyr Phe Glu Gly Leu Asp Gly Glu Gly Arg Gly Ala Asp 
     210                215                220
Leu Gly Ser Phe Pro Gly Ser Pro Gly Thr Ser Glu Asn His Pro Asp 
 225                230                235                240
Thr Glu Gly Glu Thr Pro Ser Trp Ser Leu Leu Asp Leu Tyr Asp Asp 
                 245                250                255
Phe Thr Pro Phe Asp Glu Ser Asp Phe Tyr Pro Thr Thr Ser Phe Tyr 
             260                265                270
Asp Asp Leu Asp Glu Glu Glu Glu Glu Glu Glu Asp Asp Lys Asp Ala 
         275                280                285
Val Gly Gly Gly Asp Leu Glu Asp Glu Asn Glu Leu Leu Val Pro Thr 
     290                295                300
Gly Lys Pro Gly Leu Gly Pro Gly Thr Gly Gln Pro Thr Ser Arg Trp 
 305                310                315                320
His Ala Val Pro Pro Gln His Thr Leu Gly Ser Val Pro Gly Ser Ser 
                 325                330                335
Ile Ala Leu Arg Pro Arg Pro Gly Glu Pro Gly Arg Asp Leu Ala Ser 
             340                345                350
Ser Glu Asn Gly Thr Glu Cys Arg Ser Gly Phe Val Arg His Asn Gly 
         355                360                365
Ser Cys Arg Ser Val Cys Asp Leu Phe Pro Ser Tyr Cys His Asn Gly 
     370                375                380
Gly Gln Cys Tyr Leu Val Glu Asn Ile Gly Ala Phe Cys Arg Cys Asn 
 385                390                395                400
Thr Gln Asp Tyr Ile Trp His Lys Gly Met Arg Cys Glu Ser Ile Ile 
                 405                410                415
Thr Asp Phe Gln Val Met Cys Val Ala Val Gly Ser Ala Ala Leu Val 
             420                425                430
Leu Leu Leu Leu Phe Met Met Thr Val Phe Phe Ala Lys Lys Leu Tyr 
         435                440                445
Leu Leu Lys Thr Glu Asn Thr Lys Leu Arg Arg Thr Asn Lys Phe Arg 
     450                455                460
Thr Pro Ser Glu Leu His Asn Asp Asn Phe Ser Leu Ser Thr Ile Ala 
 465                470                475                480
Glu Gly Ser His Pro Asn Asp Asp Pro Ser Ala Pro His Lys Ile Gln 
                 485                490                495
Glu Val Leu Lys Ser Cys Leu Lys Glu Glu Glu Ser Phe Asn Ile Gln 
             500                505                510
Asn Ser Met Ser Pro Lys Leu Glu Gly Gly Lys Gly Asp Gln Ala Asp 
         515                520                525
Leu Asp Val Asn Cys Leu Gln Asn Asn Leu Thr 
     530                535



<210> 8387
<211> 1683
<212> DNA
<213> Rattus norvegicus
<308> U34843
<400> 8387

gtcgaccaa  tcggcacga  ggacagggc  gcgattgac  cggcagctg  aggatgaag  60
aggagcatg  tagtcactg  cagttctcc  cgtggtacc  actcttccg  agccttacc  120
tcaagagtg  catcctccc  cttcctcag  atgtgaaag  ctatttact  gacgacggg  180
ctctggtgg  ctcaggaag  gaagaccca  caacatgct  tcagccaga  agtggtgac  240
aagcagagg  aacacagtg  tccgatgat  agagcacag  cacacttac  gcacccgag  300
ttcctgagt  caatactca  gtccaagaa  ctatcaatt  gctgggggg  agtgtcttc  360
ctaagctta  ctggagtgc  ccaagggat  catactgga  agcaatgaa  agttctctg  420
agtgtaaaa  cctcagtga  atcttcctg  ttttcaaga  ttcggactt  atcactcat  480
acttcacac  gccgtttat  cattgtaat  atgattctc  agatccttg  atagagtac  540
agcttgttc  ccgaaaatg  tgtgaatta  tccctgggg  tgagttccg  tgttttgtc  600
aggaaaaca  gcttattgg  atttctcag  gggactaca  gcagtacta  gatcatatc  660
ctaagcaaa  agaagaaat  tgcagatgc  ttcaagact  tttcaagga  cacctgcag  720
acaaattct  agatgaaga  tttgtgttt  atatataca  agacagtag  ggcaaggtg  780
ggctgatcg  ctttaaccc  tttggggag  tcacagact  tctgctgtt  acttgggaa  840
agctgacat  ggagaacaa  ctgcgaggc  acgtcagtg  ggcggacgc  ctggagcag  900
attctccag  cttccgttg  acgaacagt  aagtcacgg  ccagcccag  ccctatctg  960
gctacggcc  gcccaagga  ttcgtagac  tttccaccg  ggaagatgc  cacaagctc  1020
tagattttc  taagctgaa  agaaatcag  aagaggacg  ctgagcgct  cttggagaa  1080
aagtcaaga  ggaaacagc  tttcagaag  ctcatatag  acacaactt  ccagtgacc  1140
aaactaggt  cagatgggt  ggcagtatg  aaaatcatc  gcttttata  tcgtgtata  1200
ttacctgga  aaagatgga  gacctttgg  acttgtaaa  gaaataaca  tataataaa  1260
agatcttaa  cacaaggaa  cacactgtg  tggtttgta  atgcttggg  cagggagtg  1320
cactatgag  aggtgtggc  tggttggag  agggggtgt  actatgggt  tgggcttta  1380
gaccctagt  ctaactgcc  ggaagtcag  tttttccta  ctaccttca  ctaagttcc  1440
cctgcacca  gcctgcctg  gtgccgcca  actcccacc  tgatgataa  ggactgaaa  1500
tctgaccct  tgaacctgt  agccagccc  agtgaaatg  tgttcttat  agagttgtc  1560
tggtcatgg  gtctgctca  agcaactat  ctaagacac  cactgttct  aaaataaaa  1620
aactttcta  gaaaaaaaa  aaaaaaaaa  aaactcgag  tcgacctgc  ggcatgcaa  1680
ctt  1683



<210> 8388
<211> 337
<212> PRT
<213> Rattus norvegicus
<308> U34843
<400> 8388

Met Lys Lys Glu His Val Ser His Cys Gln Phe Ser Ala Trp Tyr Pro 
  1               5                  10                  15
Leu Phe Arg Ser Leu Thr Ile Lys Ser Val Ile Leu Pro Leu Pro Gln 
             20                  25                  30
Asn Val Lys Asp Tyr Leu Leu Asp Asp Gly Thr Leu Val Val Ser Gly 
         35                  40                  45
Arg Glu Asp Pro Pro Thr Cys Ser Gln Pro Asp Ser Gly Asp Glu Ala 
     50                  55                  60
Glu Glu Thr Gln Trp Ser Asp Asp Glu Ser Thr Ala Thr Leu Thr Ala 
 65                  70                  75                  80
Pro Glu Phe Pro Glu Phe Asn Thr Gln Val Gln Glu Ala Ile Asn Ser 
                 85                  90                  95
Leu Gly Gly Ser Val Phe Pro Lys Leu Asn Trp Ser Ala Pro Arg Asp 
             100                105                110
Ala Tyr Trp Ile Ala Met Asn Ser Ser Leu Lys Cys Lys Ser Leu Ser 
         115                120                125
Asp Ile Phe Leu Leu Phe Lys Ser Ser Asp Phe Ile Thr His Asp Phe 
     130                135                140
Thr Gln Pro Phe Ile His Cys Asn Asp Asp Ser Pro Asp Pro Cys Ile 
 145                150                155                160
Glu Tyr Glu Leu Val Leu Arg Lys Trp Cys Glu Leu Ile Pro Gly Ala 
                 165                170                175
Glu Phe Arg Cys Phe Val Lys Glu Asn Lys Leu Ile Gly Ile Ser Gln 
             180                185                190
Arg Asp Tyr Thr Gln Tyr Tyr Asp His Ile Ser Lys Gln Lys Glu Glu 
         195                200                205
Ile Cys Arg Cys Ile Gln Asp Phe Phe Lys Glu His Leu Gln Tyr Lys 
     210                215                220
Phe Leu Asp Glu Asp Phe Val Phe Asp Ile Tyr Arg Asp Ser Arg Gly 
 225                230                235                240
Lys Val Trp Leu Ile Asp Phe Asn Pro Phe Gly Glu Val Thr Asp Ser 
                 245                250                255
Leu Leu Phe Thr Trp Glu Glu Leu Thr Ser Glu Asn Asn Leu Arg Gly 
             260                265                270
Asp Val Ser Glu Ala Asp Ala Leu Glu Gln Asp Ser Pro Ala Phe Arg 
         275                280                285
Cys Thr Asn Ser Glu Val Thr Val Gln Pro Ser Pro Tyr Leu Ser Tyr 
     290                295                300
Gly Leu Pro Lys Asp Phe Val Asp Leu Ser Thr Gly Glu Asp Ala His 
 305                310                315                320
Lys Leu Ile Asp Phe Leu Lys Leu Lys Arg Asn Gln Gln Glu Asp Asp 
                 325                330                335
Ter 
             340



<210> 8389
<211> 1321
<212> DNA
<213> Homo sapiens
<308> U27112
<400> 8389

gcccagagt  ccgggaggg  gcaggcagg  gagggaaag  cagcagcgg  ggcagctgg  60
ggatgaaga  ggagcatgt  cttcactgc  agttctccg  gtggtaccc  ttcttccga  120
gcgttacca  caagagtgt  attcttcca  ttcctcaga  tgtgaagga  tatttactc  180
atgatggaa  tctggtggt  tcaggaagg  atgatccac  aacacattc  cagccagac  240
gtgatgatg  agcagaaga  atacagtgg  ctgatgatg  gaacacagc  acgcttacg  300
caccagaat  tcctgagtt  gccactaaa  tccaggaag  tatcaattc  ctcgggggc  360
gtgtctttc  taagcttaa  tggagtgcc  caagggatg  gtattggat  gcaatgaat  420
gttctctga  atgtaaaac  ctcagcgac  tctttctgc  tttcaagag  tccgatttc  480
tcactcgtg  cttcactca  ccgtttatt  attgtactg  tgattctcc  gatccatgt  540
tagaatatg  gctcgttct  cgaaaatgg  gtgaattga  tcctggggc  gagtttcga  600
gttttgtca  ggaaaacaa  cttattggt  tttctcaaa  agactacac  caatactat  660
atcatattt  taaacaaaa  gaagaaatt  gcagatgca  acaagactt  ttcaagaaa  720
acatacagt  caaattctt  gatgaagac  ttgtgttcg  tatatacag  gacagtagg  780
ggaaggtgt  gctcattga  tttaatcca  ttggtgaag  cacagattc  ctgctgttc  840
cctgggaag  actgatatc  gagaacaac  taaacggcg  ttttagtga  gttgacgct  900
aagagcagg  ttccccagc  ttccgttgc  caaacagtg  agtgacagt  cagcccagc  960
cctatttga  ttaccggct  cccaaggac  ttgtagacc  ctctactgg  gaggacgct  1020
acaagctaa  agacttcct  aagctgaag  gaaatcagc  ggaggacga  tgatgagcg  1080
actgtaact  gagaagagg  ggccccgcc  caccgctcc  ggagctgct  atcagccgc  1140
acttcctgc  gaccctgat  cgggtgggc  gagcagtgt  gacatcggc  actttttat  1200
ttcatgtac  ttcacctgg  gaaaaaaac  gagggactt  gctacttgt  aaaataaca  1260
aataaatag  tcttaaaca  aggaaaacc  tactgttct  ataataaaa  gttttctat  1320
a  1321



<210> 8390
<211> 337
<212> PRT
<213> Homo sapiens
<308> U27112
<400> 8390

Met Lys Lys Glu His Val Leu His Cys Gln Phe Ser Ala Trp Tyr Pro 
  1               5                  10                  15
Phe Phe Arg Gly Val Thr Ile Lys Ser Val Ile Leu Pro Leu Pro Gln 
             20                  25                  30
Asn Val Lys Asp Tyr Leu Leu Asp Asp Gly Thr Leu Val Val Ser Gly 
         35                  40                  45
Arg Asp Asp Pro Pro Thr His Ser Gln Pro Asp Ser Asp Asp Glu Ala 
     50                  55                  60
Glu Glu Ile Gln Trp Ser Asp Asp Glu Asn Thr Ala Thr Leu Thr Ala 
 65                  70                  75                  80
Pro Glu Phe Pro Glu Phe Ala Thr Lys Val Gln Glu Ala Ile Asn Ser 
                 85                  90                  95
Leu Gly Gly Ser Val Phe Pro Lys Leu Asn Trp Ser Ala Pro Arg Asp 
             100                105                110
Ala Tyr Trp Ile Ala Met Asn Ser Ser Leu Lys Cys Lys Thr Leu Ser 
         115                120                125
Asp Ile Phe Leu Leu Phe Lys Ser Ser Asp Phe Ile Thr Arg Asp Phe 
     130                135                140
Thr Gln Pro Phe Ile His Cys Thr Asp Asp Ser Pro Asp Pro Cys Ile 
 145                150                155                160
Glu Tyr Glu Leu Val Leu Arg Lys Trp Cys Glu Leu Ile Pro Gly Ala 
                 165                170                175
Glu Phe Arg Cys Phe Val Lys Glu Asn Lys Leu Ile Gly Ile Ser Gln 
             180                185                190
Arg Asp Tyr Thr Gln Tyr Tyr Asp His Ile Ser Lys Gln Lys Glu Glu 
         195                200                205
Ile Arg Arg Cys Ile Gln Asp Phe Phe Lys Lys His Ile Gln Tyr Lys 
     210                215                220
Phe Leu Asp Glu Asp Phe Val Phe Asp Ile Tyr Arg Asp Ser Arg Gly 
 225                230                235                240
Lys Val Trp Leu Ile Asp Phe Asn Pro Phe Gly Glu Val Thr Asp Ser 
                 245                250                255
Leu Leu Phe Thr Trp Glu Glu Leu Ile Ser Glu Asn Asn Leu Asn Gly 
             260                265                270
Asp Phe Ser Glu Val Asp Ala Gln Glu Gln Asp Ser Pro Ala Phe Arg 
         275                280                285
Cys Thr Asn Ser Glu Val Thr Val Gln Pro Ser Pro Tyr Leu Ser Tyr 
     290                295                300
Arg Leu Pro Lys Asp Phe Val Asp Leu Ser Thr Gly Glu Asp Ala His 
 305                310                315                320
Lys Leu Ile Asp Phe Leu Lys Leu Lys Arg Asn Gln Gln Glu Asp Asp 
                 325                330                335
Ter 
             340



<210> 8391
<211> 1683
<212> DNA
<213> Rattus norvegicus
<308> U34843
<400> 8391

gtcgaccaa  tcggcacga  ggacagggc  gcgattgac  cggcagctg  aggatgaag  60
aggagcatg  tagtcactg  cagttctcc  cgtggtacc  actcttccg  agccttacc  120
tcaagagtg  catcctccc  cttcctcag  atgtgaaag  ctatttact  gacgacggg  180
ctctggtgg  ctcaggaag  gaagaccca  caacatgct  tcagccaga  agtggtgac  240
aagcagagg  aacacagtg  tccgatgat  agagcacag  cacacttac  gcacccgag  300
ttcctgagt  caatactca  gtccaagaa  ctatcaatt  gctgggggg  agtgtcttc  360
ctaagctta  ctggagtgc  ccaagggat  catactgga  agcaatgaa  agttctctg  420
agtgtaaaa  cctcagtga  atcttcctg  ttttcaaga  ttcggactt  atcactcat  480
acttcacac  gccgtttat  cattgtaat  atgattctc  agatccttg  atagagtac  540
agcttgttc  ccgaaaatg  tgtgaatta  tccctgggg  tgagttccg  tgttttgtc  600
aggaaaaca  gcttattgg  atttctcag  gggactaca  gcagtacta  gatcatatc  660
ctaagcaaa  agaagaaat  tgcagatgc  ttcaagact  tttcaagga  cacctgcag  720
acaaattct  agatgaaga  tttgtgttt  atatataca  agacagtag  ggcaaggtg  780
ggctgatcg  ctttaaccc  tttggggag  tcacagact  tctgctgtt  acttgggaa  840
agctgacat  ggagaacaa  ctgcgaggc  acgtcagtg  ggcggacgc  ctggagcag  900
attctccag  cttccgttg  acgaacagt  aagtcacgg  ccagcccag  ccctatctg  960
gctacggcc  gcccaagga  ttcgtagac  tttccaccg  ggaagatgc  cacaagctc  1020
tagattttc  taagctgaa  agaaatcag  aagaggacg  ctgagcgct  cttggagaa  1080
aagtcaaga  ggaaacagc  tttcagaag  ctcatatag  acacaactt  ccagtgacc  1140
aaactaggt  cagatgggt  ggcagtatg  aaaatcatc  gcttttata  tcgtgtata  1200
ttacctgga  aaagatgga  gacctttgg  acttgtaaa  gaaataaca  tataataaa  1260
agatcttaa  cacaaggaa  cacactgtg  tggtttgta  atgcttggg  cagggagtg  1320
cactatgag  aggtgtggc  tggttggag  agggggtgt  actatgggt  tgggcttta  1380
gaccctagt  ctaactgcc  ggaagtcag  tttttccta  ctaccttca  ctaagttcc  1440
cctgcacca  gcctgcctg  gtgccgcca  actcccacc  tgatgataa  ggactgaaa  1500
tctgaccct  tgaacctgt  agccagccc  agtgaaatg  tgttcttat  agagttgtc  1560
tggtcatgg  gtctgctca  agcaactat  ctaagacac  cactgttct  aaaataaaa  1620
aactttcta  gaaaaaaaa  aaaaaaaaa  aaactcgag  tcgacctgc  ggcatgcaa  1680
ctt  1683



<210> 8392
<211> 337
<212> PRT
<213> Rattus norvegicus
<308> U34843
<400> 8392

Met Lys Lys Glu His Val Ser His Cys Gln Phe Ser Ala Trp Tyr Pro 
  1               5                  10                  15
Leu Phe Arg Ser Leu Thr Ile Lys Ser Val Ile Leu Pro Leu Pro Gln 
             20                  25                  30
Asn Val Lys Asp Tyr Leu Leu Asp Asp Gly Thr Leu Val Val Ser Gly 
         35                  40                  45
Arg Glu Asp Pro Pro Thr Cys Ser Gln Pro Asp Ser Gly Asp Glu Ala 
     50                  55                  60
Glu Glu Thr Gln Trp Ser Asp Asp Glu Ser Thr Ala Thr Leu Thr Ala 
 65                  70                  75                  80
Pro Glu Phe Pro Glu Phe Asn Thr Gln Val Gln Glu Ala Ile Asn Ser 
                 85                  90                  95
Leu Gly Gly Ser Val Phe Pro Lys Leu Asn Trp Ser Ala Pro Arg Asp 
             100                105                110
Ala Tyr Trp Ile Ala Met Asn Ser Ser Leu Lys Cys Lys Ser Leu Ser 
         115                120                125
Asp Ile Phe Leu Leu Phe Lys Ser Ser Asp Phe Ile Thr His Asp Phe 
     130                135                140
Thr Gln Pro Phe Ile His Cys Asn Asp Asp Ser Pro Asp Pro Cys Ile 
 145                150                155                160
Glu Tyr Glu Leu Val Leu Arg Lys Trp Cys Glu Leu Ile Pro Gly Ala 
                 165                170                175
Glu Phe Arg Cys Phe Val Lys Glu Asn Lys Leu Ile Gly Ile Ser Gln 
             180                185                190
Arg Asp Tyr Thr Gln Tyr Tyr Asp His Ile Ser Lys Gln Lys Glu Glu 
         195                200                205
Ile Cys Arg Cys Ile Gln Asp Phe Phe Lys Glu His Leu Gln Tyr Lys 
     210                215                220
Phe Leu Asp Glu Asp Phe Val Phe Asp Ile Tyr Arg Asp Ser Arg Gly 
 225                230                235                240
Lys Val Trp Leu Ile Asp Phe Asn Pro Phe Gly Glu Val Thr Asp Ser 
                 245                250                255
Leu Leu Phe Thr Trp Glu Glu Leu Thr Ser Glu Asn Asn Leu Arg Gly 
             260                265                270
Asp Val Ser Glu Ala Asp Ala Leu Glu Gln Asp Ser Pro Ala Phe Arg 
         275                280                285
Cys Thr Asn Ser Glu Val Thr Val Gln Pro Ser Pro Tyr Leu Ser Tyr 
     290                295                300
Gly Leu Pro Lys Asp Phe Val Asp Leu Ser Thr Gly Glu Asp Ala His 
 305                310                315                320
Lys Leu Ile Asp Phe Leu Lys Leu Lys Arg Asn Gln Gln Glu Asp Asp 
                 325                330                335
Ter 
             340



<210> 8393
<211> 1321
<212> DNA
<213> Homo sapiens
<308> U27112
<400> 8393

gcccagagt  ccgggaggg  gcaggcagg  gagggaaag  cagcagcgg  ggcagctgg  60
ggatgaaga  ggagcatgt  cttcactgc  agttctccg  gtggtaccc  ttcttccga  120
gcgttacca  caagagtgt  attcttcca  ttcctcaga  tgtgaagga  tatttactc  180
atgatggaa  tctggtggt  tcaggaagg  atgatccac  aacacattc  cagccagac  240
gtgatgatg  agcagaaga  atacagtgg  ctgatgatg  gaacacagc  acgcttacg  300
caccagaat  tcctgagtt  gccactaaa  tccaggaag  tatcaattc  ctcgggggc  360
gtgtctttc  taagcttaa  tggagtgcc  caagggatg  gtattggat  gcaatgaat  420
gttctctga  atgtaaaac  ctcagcgac  tctttctgc  tttcaagag  tccgatttc  480
tcactcgtg  cttcactca  ccgtttatt  attgtactg  tgattctcc  gatccatgt  540
tagaatatg  gctcgttct  cgaaaatgg  gtgaattga  tcctggggc  gagtttcga  600
gttttgtca  ggaaaacaa  cttattggt  tttctcaaa  agactacac  caatactat  660
atcatattt  taaacaaaa  gaagaaatt  gcagatgca  acaagactt  ttcaagaaa  720
acatacagt  caaattctt  gatgaagac  ttgtgttcg  tatatacag  gacagtagg  780
ggaaggtgt  gctcattga  tttaatcca  ttggtgaag  cacagattc  ctgctgttc  840
cctgggaag  actgatatc  gagaacaac  taaacggcg  ttttagtga  gttgacgct  900
aagagcagg  ttccccagc  ttccgttgc  caaacagtg  agtgacagt  cagcccagc  960
cctatttga  ttaccggct  cccaaggac  ttgtagacc  ctctactgg  gaggacgct  1020
acaagctaa  agacttcct  aagctgaag  gaaatcagc  ggaggacga  tgatgagcg  1080
actgtaact  gagaagagg  ggccccgcc  caccgctcc  ggagctgct  atcagccgc  1140
acttcctgc  gaccctgat  cgggtgggc  gagcagtgt  gacatcggc  actttttat  1200
ttcatgtac  ttcacctgg  gaaaaaaac  gagggactt  gctacttgt  aaaataaca  1260
aataaatag  tcttaaaca  aggaaaacc  tactgttct  ataataaaa  gttttctat  1320
a  1321



<210> 8394
<211> 337
<212> PRT
<213> Homo sapiens
<308> U27112
<400> 8394

Met Lys Lys Glu His Val Leu His Cys Gln Phe Ser Ala Trp Tyr Pro 
  1               5                  10                  15
Phe Phe Arg Gly Val Thr Ile Lys Ser Val Ile Leu Pro Leu Pro Gln 
             20                  25                  30
Asn Val Lys Asp Tyr Leu Leu Asp Asp Gly Thr Leu Val Val Ser Gly 
         35                  40                  45
Arg Asp Asp Pro Pro Thr His Ser Gln Pro Asp Ser Asp Asp Glu Ala 
     50                  55                  60
Glu Glu Ile Gln Trp Ser Asp Asp Glu Asn Thr Ala Thr Leu Thr Ala 
 65                  70                  75                  80
Pro Glu Phe Pro Glu Phe Ala Thr Lys Val Gln Glu Ala Ile Asn Ser 
                 85                  90                  95
Leu Gly Gly Ser Val Phe Pro Lys Leu Asn Trp Ser Ala Pro Arg Asp 
             100                105                110
Ala Tyr Trp Ile Ala Met Asn Ser Ser Leu Lys Cys Lys Thr Leu Ser 
         115                120                125
Asp Ile Phe Leu Leu Phe Lys Ser Ser Asp Phe Ile Thr Arg Asp Phe 
     130                135                140
Thr Gln Pro Phe Ile His Cys Thr Asp Asp Ser Pro Asp Pro Cys Ile 
 145                150                155                160
Glu Tyr Glu Leu Val Leu Arg Lys Trp Cys Glu Leu Ile Pro Gly Ala 
                 165                170                175
Glu Phe Arg Cys Phe Val Lys Glu Asn Lys Leu Ile Gly Ile Ser Gln 
             180                185                190
Arg Asp Tyr Thr Gln Tyr Tyr Asp His Ile Ser Lys Gln Lys Glu Glu 
         195                200                205
Ile Arg Arg Cys Ile Gln Asp Phe Phe Lys Lys His Ile Gln Tyr Lys 
     210                215                220
Phe Leu Asp Glu Asp Phe Val Phe Asp Ile Tyr Arg Asp Ser Arg Gly 
 225                230                235                240
Lys Val Trp Leu Ile Asp Phe Asn Pro Phe Gly Glu Val Thr Asp Ser 
                 245                250                255
Leu Leu Phe Thr Trp Glu Glu Leu Ile Ser Glu Asn Asn Leu Asn Gly 
             260                265                270
Asp Phe Ser Glu Val Asp Ala Gln Glu Gln Asp Ser Pro Ala Phe Arg 
         275                280                285
Cys Thr Asn Ser Glu Val Thr Val Gln Pro Ser Pro Tyr Leu Ser Tyr 
     290                295                300
Arg Leu Pro Lys Asp Phe Val Asp Leu Ser Thr Gly Glu Asp Ala His 
 305                310                315                320
Lys Leu Ile Asp Phe Leu Lys Leu Lys Arg Asn Gln Gln Glu Asp Asp 
                 325                330                335
Ter 
             340



<210> 8395
<211> 2222
<212> DNA
<213> Rattus norvegicus
<308> U34932
<400> 8395

gcggccgcg  cgacgtgcc  tcaccagtg  gtgcgggaa  ccgccgttt  ggctgagac  60
atggcagct  cgccagcag  cctagcgct  gatccccag  cccaagagg  gcaaaagga  120
gcatccgaa  caagtgagc  cagtaggct  cgtgccgaa  tggccggtg  actggcaga  180
atggaaacc  tgaaggctg  agctgaggt  agcgagagc  ccaaggcag  ggcggtggc  240
gcagtgcag  gacagtgcc  agaggaggt  gcttccctg  aggccatcc  gaaagactc  300
atcagcagc  acgagaccc  gatcgcagc  ctgaaacag  agcggcagc  gcagcaaca  360
gactctgag  agaaggagc  agagctggg  cacctcaaa  agctgctgg  ccgggccca  420
cctttggac  ccttggaga  gcaaatgga  aaggctcac  aagactcag  aaagcttcg  480
gagatcgtg  tgcccatgg  gcaggagat  gcagagctg  aggtgaagc  gctgagggc  540
gaagagctg  tccaagaga  ccagagacg  ccaaggcag  ctgcctccc  gcatggctc  600
acagagttg  ttccactat  aaggaaccc  tcaccacca  tggaaccct  ggaggaacc  660
agtggagac  caggcccag  tgctgaggc  ttcgcccac  actgtgatg  cagtgcctc  720
atctcttcc  tctccctcg  tggggccgc  ggtagtgtc  ccctacgag  tccccaagg  780
ctcagcccc  agcaggaag  gacagcttc  ctggtgtct  ctggcactc  ggtccccga  840
ggcatctac  taccccctc  ggggtacca  cttgttcca  acagccagt  ggagcaact  900
caggtagag  ggcggcagc  gcagaagga  ctggaaagt  tccgccgtg  gcgggatga  960
ctgcaggaa  gactgagcc  gagcaatga  gactgtgcc  agcagatgc  ggtgctcct  1020
gcccaggtc  agaactcag  gcagctgct  cgaactctg  agggaaccg  gagccaggc  1080
caggagcgg  tgcagcggc  gatggcaga  ctggccact  ctcacaagt  cctgagcca  1140
gaggttaaa  gactgaatg  agaaaatcg  ggactccgg  ctgagcagc  gccatcctc  1200
gccctccag  gctcagagc  gcaggagga  caggacgag  ccctgccaa  ctccataca  1260
gagctacac  agctggtgc  gcacacccg  cagcaggct  gggccaggc  gcaggcaca  1320
gagcatgag  ctgagcgcc  gcgcattga  attgtgaag  tgcgggagg  actagacga  1380
gagacagca  ccaaggcca  tctggaggg  cagctgagg  tgcagcgag  agagacaga  1440
gtgctggag  cctccctgt  cagcctgag  atagagaca  agcgggtcc  acaagagca  1500
cacaaggcc  agctcacag  tctcctctc  gaacagaga  ccaaggcac  acggctgca  1560
gctgagctg  agaccagtg  acaggtgca  agggacttc  tacggctat  ccaggccct  1620
caggtgcgc  tggagcaga  ccgccaagc  gacactctg  agcaagtac  tagcattct  1680
gacgaggca  ccctcaggg  cattaagga  attaaggac  cgtgagggg  caggcgaga  1740
gcctccctg  tggggaagc  gccccattc  ctaccagaa  tgtgaggtg  tgactgcag  1800
tctcagaat  gagtccgtc  gctgcaaac  tggacagtg  tgtcccggg  cactacttc  1860
acccagggt  gctggccct  ccctcaggg  tgatacctg  aagagggtc  tagcctcct  1920
ccagaacca  agctttcag  ctgccatgc  ccctcatgg  tccagttct  ccaccccgt  1980
acctcgggc  agcagccag  cccactctc  gcgtaccca  cttatggct  gaagctgtt  2040
gattcagtg  ctcctcaca  agaggccct  ggacacaca  ctgctttct  gactgtatg  2100
cactaaggt  tttgtccat  ggtacccga  ataggcccc  agacataag  aagcaaggc  2160
agacttttc  gtcatttat  ttcaataaa  aagcagtca  ctaaaaaaa  aaaaaaaaa  2220
aa  2222



<210> 8396
<211> 554
<212> PRT
<213> Rattus norvegicus
<308> AAA79137
<400> 8396

Met Ala Ala Ala Pro Ala Ala Leu Ala Leu Asp Pro Gln Pro Gln Glu 
  1               5                  10                  15
Glu Gln Lys Asp Ala Ser Glu Ser Ser Glu Leu Ser Arg Leu Arg Ala 
             20                  25                  30
Glu Leu Ala Gly Ala Leu Ala Glu Met Glu Thr Met Lys Ala Val Ala 
         35                  40                  45
Glu Val Ser Glu Ser Thr Lys Ala Glu Ala Val Ala Ala Val Gln Arg 
     50                  55                  60
Gln Cys Gln Glu Glu Val Ala Ser Leu Gln Ala Ile Leu Lys Asp Ser 
 65                  70                  75                  80
Ile Ser Ser Tyr Glu Thr Gln Ile Ala Ala Leu Lys Gln Glu Arg Gln 
                 85                  90                  95
Gln Gln Gln Gln Asp Ser Glu Glu Lys Glu Arg Glu Leu Gly His Leu 
             100                105                110
Lys Gln Leu Leu Ala Arg Ala His Pro Leu Asp Ser Leu Glu Lys Gln 
         115                120                125
Met Glu Lys Ala His Glu Asp Ser Glu Lys Leu Arg Glu Ile Val Leu 
     130                135                140
Pro Met Glu Gln Glu Ile Ala Glu Leu Lys Val Lys Leu Leu Arg Ala 
 145                150                155                160
Glu Glu Leu Ile Gln Glu Ile Gln Arg Arg Pro Arg Gln Pro Ala Ser 
                 165                170                175
Leu His Gly Ser Thr Glu Leu Leu Pro Leu Ser Arg Asn Pro Ser Pro 
             180                185                190
Pro Leu Glu Pro Ser Glu Glu Pro Ser Gly Asp Ala Gly Pro Ala Ala 
         195                200                205
Glu Ala Phe Ala His Asn Cys Asp Asp Ser Ala Ser Ile Ser Ser Phe 
     210                215                220
Ser Leu Gly Gly Ala Ala Gly Ser Val Ser Leu Arg Gly Pro Gln Gly 
 225                230                235                240
Leu Ser Pro Glu Gln Glu Glu Thr Ala Ser Leu Val Ser Thr Gly Thr 
                 245                250                255
Leu Val Pro Glu Gly Ile Tyr Leu Pro Pro Pro Gly Tyr Gln Leu Val 
             260                265                270
Pro Asp Ser Gln Trp Glu Gln Leu Gln Val Glu Gly Arg Gln Leu Gln 
         275                280                285
Lys Glu Leu Glu Ser Val Arg Arg Glu Arg Asp Glu Leu Gln Glu Gly 
     290                295                300
Leu Ser Arg Ser Asn Glu Asp Cys Ala Lys Gln Met Gln Val Leu Leu 
 305                310                315                320
Ala Gln Val Gln Asn Ser Glu Gln Leu Leu Arg Thr Leu Gln Gly Thr 
                 325                330                335
Val Ser Gln Ala Gln Glu Arg Val Gln Arg Gln Met Ala Glu Leu Ala 
             340                345                350
Thr Ser His Lys Cys Leu Ser Gln Glu Val Lys Arg Leu Asn Glu Glu 
         355                360                365
Asn Arg Gly Leu Arg Ala Glu Gln Leu Pro Ser Ser Ala Leu Gln Gly 
     370                375                380
Ser Glu Gln Gln Glu Asp Gln Asp Glu Ala Leu Pro Ser Ser Ile Gln 
 385                390                395                400
Glu Leu His Gln Leu Val Arg His Thr Arg Gln Gln Ala Arg Ala Arg 
                 405                410                415
Gln Gln Ala Gln Glu His Glu Ala Glu Arg Leu Arg Ile Glu Ile Val 
             420                425                430
Lys Leu Arg Glu Ala Leu Asp Glu Glu Thr Ala Ala Lys Ala Ser Leu 
         435                440                445
Glu Gly Gln Leu Arg Val Gln Arg Glu Glu Thr Asp Val Leu Glu Ala 
     450                455                460
Ser Leu Cys Ser Leu Arg Ile Glu Thr Glu Arg Val Gln Gln Glu His 
 465                470                475                480
His Lys Ala Gln Leu Thr Asp Leu Leu Ser Glu Gln Arg Ala Lys Ala 
                 485                490                495
Leu Arg Leu Gln Ala Glu Leu Glu Thr Ser Glu Gln Val Gln Arg Asp 
             500                505                510
Phe Val Arg Leu Ser Gln Ala Leu Gln Val Arg Leu Glu Gln Ile Arg 
         515                520                525
Gln Ala Asp Thr Leu Glu Gln Val Arg Ser Ile Leu Asp Glu Ala Pro 
     530                535                540
Leu Arg Asp Ile Lys Asp Ile Lys Asp Ser 
 545                550



<210> 8397
<211> 2309
<212> DNA
<213> Homo sapiens
<308> NM_024816
<400> 8397

gcgctccgt  accagggag  gcgggaatc  gccgtttgc  ctgaggcaa  ggcggcagc  60
gcgccggtg  ccgcggacg  cgatgagcg  cggcggcgg  cgggggctg  actggagga  120
tcccggtcc  aggaagggg  aaatggtga  gccgagtca  gtgagctca  ccggcttcg  180
gctgagctg  caggcgccc  ggcagaaat  gaaaccatg  aggctgtgg  agaggtgag  240
gagagcacg  aggccgagg  tgtggctgc  gtgcagcgg  agtgccaag  ggaggtggc  300
tcgctgcag  ccatcctga  agactccat  agcagctat  aagcccaga  caccgccct  360
aagcaggag  gacagcagc  gcagcagga  tgtgaggag  aggagcggg  gctgggccg  420
ctgaagcag  tgctgtccc  ggcctaccc  ctggactcc  tggagaagc  gatggaaaa  480
gcccacgag  actcggaga  gctgcggga  atcgtactg  ccatggaaa  ggagatcga  540
gagctgaag  cgaagctgc  gagggccga  gagctgatt  aggagatcc  gagacgtcc  600
cggcatgcc  cttccctgc  cggctccac  gagttgctg  ccctgtccc  ggatccatc  660
cccccgctg  agcctctgg  ggagctgag  ggagatggg  gtccagccg  tgaggcctt  720
gctcacaac  gcgatgaca  cgcctccat  tcctccttc  cccttggcg  tggggtcgg  780
agcagctcc  ccctgcccc  aagccgcca  ggcctgagc  ctgaacagg  agagacggc  840
tcgctggtg  ctacgggca  cctggttcc  gagggcatc  acctgcccc  tcctggcta  900
cagctcgtc  cagacactc  gtgggagca  ctgcagaca  agggccgac  gctgcagaa  960
gacctggag  gcgtcagtc  cgagcggga  gagctccaa  agggcctga  acggagcaa  1020
gaggactgt  ccaagcaga  gcaggtgct  ctggcccag  tccagaact  agagcagct  1080
ctgcggacc  tgcaaggga  cgtgagcca  gcccaggag  gggtgcagc  gcagatggc  1140
gagctggtc  ccacccaca  gtgcctgca  catgaggta  agcggttga  tgaggaaaa  1200
caagggctc  gggccgagc  gctgccatc  tcagccccc  agggctcgc  gcaggagca  1260
ggcgaggag  aatcactgc  cagctctgt  ccagagctg  agcagctgc  gtgctgcac  1320
cggcaagag  cgagggccc  gctgcaggc  caggagcac  gggccgagc  cctgcggat  1380
gagatcgtg  cgctgcggg  ggctctgga  gaggagaca  tggccaggg  cagcctgga  1440
gggcagctg  gggtgcagc  ggaggagac  gaggtgctg  aggcctccc  gtgcagcct  1500
aggacagag  tggagcggg  gcagcagga  cagagcaag  cccagctcc  agacctcct  1560
tcagaacag  gggccaagg  gctgcggct  caggcagag  tggagacca  tgagcagtg  1620
agagggatt  cgtgcgact  tcccaggcc  tgcaggtgc  cctagagcg  atccgccag  1680
ctgagaccc  ggagcaagt  cgcagcatc  tggatgagg  gccactcac  gacgtcagg  1740
acatcaagg  cacctgagg  gtcaggata  ccccacccc  accctggga  agacgcctt  1800
ccccactcc  gaaccatga  gcctcgctc  ggggtcttg  atggctttt  caccgtccc  1860
gagactggg  ttgagggga  tgacggggg  caccaccgc  ccgccctcc  gcgcctcct  1920
ccagggtgg  tgggcctcc  gttctcagg  gtcacacct  ggtgagggg  ccaagcccc  1980
cccggaacc  aaggtgcag  ctcaggcct  cggctttct  gctgctgtg  tgcctcctg  2040
gctccagcc  tcccctgcc  ccagcccgt  ccctgccca  ggcacagcg  agccatggg  2100
gctgggagt  cccatcaga  gcagtgagg  gggccccgg  cctgggaca  gcagctgcc  2160
tctggtctg  atgacacta  gacgcttgt  cacagcggc  acccagacc  ccaagcttg  2220
acagaggca  ggccagact  ttccgtcgt  tattttcaa  aaataagca  ctcagcgca  2280
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2309



<210> 8398
<211> 538
<212> PRT
<213> Homo sapiens
<308> NP_079092
<400> 8398

Met Ala Ala Ala Ala Pro Val Ala Ala Asp Asp Asp Glu Arg Arg Arg 
  1               5                  10                  15
Arg Pro Gly Ala Ala Leu Glu Asp Ser Arg Ser Gln Glu Gly Ala Asn 
             20                  25                  30
Gly Glu Ala Glu Ser Gly Glu Leu Ser Arg Leu Arg Ala Glu Leu Ala 
         35                  40                  45
Gly Ala Leu Ala Glu Met Glu Thr Met Lys Ala Val Ala Glu Val Ser 
     50                  55                  60
Glu Ser Thr Lys Ala Glu Ala Val Ala Ala Val Gln Arg Gln Cys Gln 
 65                  70                  75                  80
Glu Glu Val Ala Ser Leu Gln Ala Ile Leu Lys Asp Ser Ile Ser Ser 
                 85                  90                  95
Tyr Glu Ala Gln Ile Thr Ala Leu Lys Gln Glu Arg Gln Gln Gln Gln 
             100                105                110
Gln Asp Cys Glu Glu Lys Glu Arg Glu Leu Gly Arg Leu Lys Gln Leu 
         115                120                125
Leu Ser Arg Ala Tyr Pro Leu Asp Ser Leu Glu Lys Gln Met Glu Lys 
     130                135                140
Ala His Glu Asp Ser Glu Lys Leu Arg Glu Ile Val Leu Pro Met Glu 
 145                150                155                160
Lys Glu Ile Glu Glu Leu Lys Ala Lys Leu Leu Arg Ala Glu Glu Leu 
                 165                170                175
Ile Gln Glu Ile Gln Arg Arg Pro Arg His Ala Pro Ser Leu His Gly 
             180                185                190
Ser Thr Glu Leu Leu Pro Leu Ser Arg Asp Pro Ser Pro Pro Leu Glu 
         195                200                205
Pro Leu Glu Glu Leu Ser Gly Asp Gly Gly Pro Ala Ala Glu Ala Phe 
     210                215                220
Ala His Asn Cys Asp Asp Ser Ala Ser Ile Ser Ser Phe Ser Leu Gly 
 225                230                235                240
Gly Gly Val Gly Ser Ser Ser Ser Leu Pro Gln Ser Arg Gln Gly Leu 
                 245                250                255
Ser Pro Glu Gln Glu Glu Thr Ala Ser Leu Val Ser Thr Gly Thr Leu 
             260                265                270
Val Pro Glu Gly Ile Tyr Leu Pro Pro Pro Gly Tyr Gln Leu Val Pro 
         275                280                285
Asp Thr Gln Trp Glu Gln Leu Gln Thr Glu Gly Arg Gln Leu Gln Lys 
     290                295                300
Asp Leu Glu Ser Val Ser Arg Glu Arg Asp Glu Leu Gln Glu Gly Leu 
 305                310                315                320
Arg Arg Ser Asn Glu Asp Cys Ala Lys Gln Met Gln Val Leu Leu Ala 
                 325                330                335
Gln Val Gln Asn Ser Glu Gln Leu Leu Arg Thr Leu Gln Gly Thr Val 
             340                345                350
Ser Gln Ala Gln Glu Arg Val Gln Leu Gln Met Ala Glu Leu Val Thr 
         355                360                365
Thr His Lys Cys Leu His His Glu Val Lys Arg Leu Asn Glu Glu Asn 
     370                375                380
Gln Gly Leu Arg Ala Glu Gln Leu Pro Ser Ser Ala Pro Gln Gly Ser 
 385                390                395                400
Gln Gln Glu Gln Gly Glu Glu Glu Ser Leu Pro Ser Ser Val Pro Glu 
                 405                410                415
Leu Gln Gln Leu Leu Cys Cys Thr Arg Gln Glu Ala Arg Ala Arg Leu 
             420                425                430
Gln Ala Gln Glu His Gly Ala Glu Arg Leu Arg Ile Glu Ile Val Thr 
         435                440                445
Leu Arg Glu Ala Leu Glu Glu Glu Thr Val Ala Arg Ala Ser Leu Glu 
     450                455                460
Gly Gln Leu Arg Val Gln Arg Glu Glu Thr Glu Val Leu Glu Ala Ser 
 465                470                475                480
Leu Cys Ser Leu Arg Thr Glu Met Glu Arg Val Gln Gln Glu Gln Ser 
                 485                490                495
Lys Ala Gln Leu Pro Asp Leu Leu Ser Glu Gln Arg Ala Lys Val Leu 
             500                505                510
Arg Leu Gln Ala Glu Leu Glu Thr Ser Glu Gln Cys Arg Gly Ile Ser 
         515                520                525
Cys Asp Cys Pro Arg Pro Cys Arg Cys Ala 
     530                535



<210> 8399
<211> 2222
<212> DNA
<213> Rattus norvegicus
<308> U34932
<400> 8399

gcggccgcg  cgacgtgcc  tcaccagtg  gtgcgggaa  ccgccgttt  ggctgagac  60
atggcagct  cgccagcag  cctagcgct  gatccccag  cccaagagg  gcaaaagga  120
gcatccgaa  caagtgagc  cagtaggct  cgtgccgaa  tggccggtg  actggcaga  180
atggaaacc  tgaaggctg  agctgaggt  agcgagagc  ccaaggcag  ggcggtggc  240
gcagtgcag  gacagtgcc  agaggaggt  gcttccctg  aggccatcc  gaaagactc  300
atcagcagc  acgagaccc  gatcgcagc  ctgaaacag  agcggcagc  gcagcaaca  360
gactctgag  agaaggagc  agagctggg  cacctcaaa  agctgctgg  ccgggccca  420
cctttggac  ccttggaga  gcaaatgga  aaggctcac  aagactcag  aaagcttcg  480
gagatcgtg  tgcccatgg  gcaggagat  gcagagctg  aggtgaagc  gctgagggc  540
gaagagctg  tccaagaga  ccagagacg  ccaaggcag  ctgcctccc  gcatggctc  600
acagagttg  ttccactat  aaggaaccc  tcaccacca  tggaaccct  ggaggaacc  660
agtggagac  caggcccag  tgctgaggc  ttcgcccac  actgtgatg  cagtgcctc  720
atctcttcc  tctccctcg  tggggccgc  ggtagtgtc  ccctacgag  tccccaagg  780
ctcagcccc  agcaggaag  gacagcttc  ctggtgtct  ctggcactc  ggtccccga  840
ggcatctac  taccccctc  ggggtacca  cttgttcca  acagccagt  ggagcaact  900
caggtagag  ggcggcagc  gcagaagga  ctggaaagt  tccgccgtg  gcgggatga  960
ctgcaggaa  gactgagcc  gagcaatga  gactgtgcc  agcagatgc  ggtgctcct  1020
gcccaggtc  agaactcag  gcagctgct  cgaactctg  agggaaccg  gagccaggc  1080
caggagcgg  tgcagcggc  gatggcaga  ctggccact  ctcacaagt  cctgagcca  1140
gaggttaaa  gactgaatg  agaaaatcg  ggactccgg  ctgagcagc  gccatcctc  1200
gccctccag  gctcagagc  gcaggagga  caggacgag  ccctgccaa  ctccataca  1260
gagctacac  agctggtgc  gcacacccg  cagcaggct  gggccaggc  gcaggcaca  1320
gagcatgag  ctgagcgcc  gcgcattga  attgtgaag  tgcgggagg  actagacga  1380
gagacagca  ccaaggcca  tctggaggg  cagctgagg  tgcagcgag  agagacaga  1440
gtgctggag  cctccctgt  cagcctgag  atagagaca  agcgggtcc  acaagagca  1500
cacaaggcc  agctcacag  tctcctctc  gaacagaga  ccaaggcac  acggctgca  1560
gctgagctg  agaccagtg  acaggtgca  agggacttc  tacggctat  ccaggccct  1620
caggtgcgc  tggagcaga  ccgccaagc  gacactctg  agcaagtac  tagcattct  1680
gacgaggca  ccctcaggg  cattaagga  attaaggac  cgtgagggg  caggcgaga  1740
gcctccctg  tggggaagc  gccccattc  ctaccagaa  tgtgaggtg  tgactgcag  1800
tctcagaat  gagtccgtc  gctgcaaac  tggacagtg  tgtcccggg  cactacttc  1860
acccagggt  gctggccct  ccctcaggg  tgatacctg  aagagggtc  tagcctcct  1920
ccagaacca  agctttcag  ctgccatgc  ccctcatgg  tccagttct  ccaccccgt  1980
acctcgggc  agcagccag  cccactctc  gcgtaccca  cttatggct  gaagctgtt  2040
gattcagtg  ctcctcaca  agaggccct  ggacacaca  ctgctttct  gactgtatg  2100
cactaaggt  tttgtccat  ggtacccga  ataggcccc  agacataag  aagcaaggc  2160
agacttttc  gtcatttat  ttcaataaa  aagcagtca  ctaaaaaaa  aaaaaaaaa  2220
aa  2222



<210> 8400
<211> 554
<212> PRT
<213> Rattus norvegicus
<308> AAA79137
<400> 8400

Met Ala Ala Ala Pro Ala Ala Leu Ala Leu Asp Pro Gln Pro Gln Glu 
  1               5                  10                  15
Glu Gln Lys Asp Ala Ser Glu Ser Ser Glu Leu Ser Arg Leu Arg Ala 
             20                  25                  30
Glu Leu Ala Gly Ala Leu Ala Glu Met Glu Thr Met Lys Ala Val Ala 
         35                  40                  45
Glu Val Ser Glu Ser Thr Lys Ala Glu Ala Val Ala Ala Val Gln Arg 
     50                  55                  60
Gln Cys Gln Glu Glu Val Ala Ser Leu Gln Ala Ile Leu Lys Asp Ser 
 65                  70                  75                  80
Ile Ser Ser Tyr Glu Thr Gln Ile Ala Ala Leu Lys Gln Glu Arg Gln 
                 85                  90                  95
Gln Gln Gln Gln Asp Ser Glu Glu Lys Glu Arg Glu Leu Gly His Leu 
             100                105                110
Lys Gln Leu Leu Ala Arg Ala His Pro Leu Asp Ser Leu Glu Lys Gln 
         115                120                125
Met Glu Lys Ala His Glu Asp Ser Glu Lys Leu Arg Glu Ile Val Leu 
     130                135                140
Pro Met Glu Gln Glu Ile Ala Glu Leu Lys Val Lys Leu Leu Arg Ala 
 145                150                155                160
Glu Glu Leu Ile Gln Glu Ile Gln Arg Arg Pro Arg Gln Pro Ala Ser 
                 165                170                175
Leu His Gly Ser Thr Glu Leu Leu Pro Leu Ser Arg Asn Pro Ser Pro 
             180                185                190
Pro Leu Glu Pro Ser Glu Glu Pro Ser Gly Asp Ala Gly Pro Ala Ala 
         195                200                205
Glu Ala Phe Ala His Asn Cys Asp Asp Ser Ala Ser Ile Ser Ser Phe 
     210                215                220
Ser Leu Gly Gly Ala Ala Gly Ser Val Ser Leu Arg Gly Pro Gln Gly 
 225                230                235                240
Leu Ser Pro Glu Gln Glu Glu Thr Ala Ser Leu Val Ser Thr Gly Thr 
                 245                250                255
Leu Val Pro Glu Gly Ile Tyr Leu Pro Pro Pro Gly Tyr Gln Leu Val 
             260                265                270
Pro Asp Ser Gln Trp Glu Gln Leu Gln Val Glu Gly Arg Gln Leu Gln 
         275                280                285
Lys Glu Leu Glu Ser Val Arg Arg Glu Arg Asp Glu Leu Gln Glu Gly 
     290                295                300
Leu Ser Arg Ser Asn Glu Asp Cys Ala Lys Gln Met Gln Val Leu Leu 
 305                310                315                320
Ala Gln Val Gln Asn Ser Glu Gln Leu Leu Arg Thr Leu Gln Gly Thr 
                 325                330                335
Val Ser Gln Ala Gln Glu Arg Val Gln Arg Gln Met Ala Glu Leu Ala 
             340                345                350
Thr Ser His Lys Cys Leu Ser Gln Glu Val Lys Arg Leu Asn Glu Glu 
         355                360                365
Asn Arg Gly Leu Arg Ala Glu Gln Leu Pro Ser Ser Ala Leu Gln Gly 
     370                375                380
Ser Glu Gln Gln Glu Asp Gln Asp Glu Ala Leu Pro Ser Ser Ile Gln 
 385                390                395                400
Glu Leu His Gln Leu Val Arg His Thr Arg Gln Gln Ala Arg Ala Arg 
                 405                410                415
Gln Gln Ala Gln Glu His Glu Ala Glu Arg Leu Arg Ile Glu Ile Val 
             420                425                430
Lys Leu Arg Glu Ala Leu Asp Glu Glu Thr Ala Ala Lys Ala Ser Leu 
         435                440                445
Glu Gly Gln Leu Arg Val Gln Arg Glu Glu Thr Asp Val Leu Glu Ala 
     450                455                460
Ser Leu Cys Ser Leu Arg Ile Glu Thr Glu Arg Val Gln Gln Glu His 
 465                470                475                480
His Lys Ala Gln Leu Thr Asp Leu Leu Ser Glu Gln Arg Ala Lys Ala 
                 485                490                495
Leu Arg Leu Gln Ala Glu Leu Glu Thr Ser Glu Gln Val Gln Arg Asp 
             500                505                510
Phe Val Arg Leu Ser Gln Ala Leu Gln Val Arg Leu Glu Gln Ile Arg 
         515                520                525
Gln Ala Asp Thr Leu Glu Gln Val Arg Ser Ile Leu Asp Glu Ala Pro 
     530                535                540
Leu Arg Asp Ile Lys Asp Ile Lys Asp Ser 
 545                550



<210> 8401
<211> 2309
<212> DNA
<213> Homo sapiens
<308> NM_024816
<400> 8401

gcgctccgt  accagggag  gcgggaatc  gccgtttgc  ctgaggcaa  ggcggcagc  60
gcgccggtg  ccgcggacg  cgatgagcg  cggcggcgg  cgggggctg  actggagga  120
tcccggtcc  aggaagggg  aaatggtga  gccgagtca  gtgagctca  ccggcttcg  180
gctgagctg  caggcgccc  ggcagaaat  gaaaccatg  aggctgtgg  agaggtgag  240
gagagcacg  aggccgagg  tgtggctgc  gtgcagcgg  agtgccaag  ggaggtggc  300
tcgctgcag  ccatcctga  agactccat  agcagctat  aagcccaga  caccgccct  360
aagcaggag  gacagcagc  gcagcagga  tgtgaggag  aggagcggg  gctgggccg  420
ctgaagcag  tgctgtccc  ggcctaccc  ctggactcc  tggagaagc  gatggaaaa  480
gcccacgag  actcggaga  gctgcggga  atcgtactg  ccatggaaa  ggagatcga  540
gagctgaag  cgaagctgc  gagggccga  gagctgatt  aggagatcc  gagacgtcc  600
cggcatgcc  cttccctgc  cggctccac  gagttgctg  ccctgtccc  ggatccatc  660
cccccgctg  agcctctgg  ggagctgag  ggagatggg  gtccagccg  tgaggcctt  720
gctcacaac  gcgatgaca  cgcctccat  tcctccttc  cccttggcg  tggggtcgg  780
agcagctcc  ccctgcccc  aagccgcca  ggcctgagc  ctgaacagg  agagacggc  840
tcgctggtg  ctacgggca  cctggttcc  gagggcatc  acctgcccc  tcctggcta  900
cagctcgtc  cagacactc  gtgggagca  ctgcagaca  agggccgac  gctgcagaa  960
gacctggag  gcgtcagtc  cgagcggga  gagctccaa  agggcctga  acggagcaa  1020
gaggactgt  ccaagcaga  gcaggtgct  ctggcccag  tccagaact  agagcagct  1080
ctgcggacc  tgcaaggga  cgtgagcca  gcccaggag  gggtgcagc  gcagatggc  1140
gagctggtc  ccacccaca  gtgcctgca  catgaggta  agcggttga  tgaggaaaa  1200
caagggctc  gggccgagc  gctgccatc  tcagccccc  agggctcgc  gcaggagca  1260
ggcgaggag  aatcactgc  cagctctgt  ccagagctg  agcagctgc  gtgctgcac  1320
cggcaagag  cgagggccc  gctgcaggc  caggagcac  gggccgagc  cctgcggat  1380
gagatcgtg  cgctgcggg  ggctctgga  gaggagaca  tggccaggg  cagcctgga  1440
gggcagctg  gggtgcagc  ggaggagac  gaggtgctg  aggcctccc  gtgcagcct  1500
aggacagag  tggagcggg  gcagcagga  cagagcaag  cccagctcc  agacctcct  1560
tcagaacag  gggccaagg  gctgcggct  caggcagag  tggagacca  tgagcagtg  1620
agagggatt  cgtgcgact  tcccaggcc  tgcaggtgc  cctagagcg  atccgccag  1680
ctgagaccc  ggagcaagt  cgcagcatc  tggatgagg  gccactcac  gacgtcagg  1740
acatcaagg  cacctgagg  gtcaggata  ccccacccc  accctggga  agacgcctt  1800
ccccactcc  gaaccatga  gcctcgctc  ggggtcttg  atggctttt  caccgtccc  1860
gagactggg  ttgagggga  tgacggggg  caccaccgc  ccgccctcc  gcgcctcct  1920
ccagggtgg  tgggcctcc  gttctcagg  gtcacacct  ggtgagggg  ccaagcccc  1980
cccggaacc  aaggtgcag  ctcaggcct  cggctttct  gctgctgtg  tgcctcctg  2040
gctccagcc  tcccctgcc  ccagcccgt  ccctgccca  ggcacagcg  agccatggg  2100
gctgggagt  cccatcaga  gcagtgagg  gggccccgg  cctgggaca  gcagctgcc  2160
tctggtctg  atgacacta  gacgcttgt  cacagcggc  acccagacc  ccaagcttg  2220
acagaggca  ggccagact  ttccgtcgt  tattttcaa  aaataagca  ctcagcgca  2280
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2309



<210> 8402
<211> 538
<212> PRT
<213> Homo sapiens
<308> NP_079092
<400> 8402

Met Ala Ala Ala Ala Pro Val Ala Ala Asp Asp Asp Glu Arg Arg Arg 
  1               5                  10                  15
Arg Pro Gly Ala Ala Leu Glu Asp Ser Arg Ser Gln Glu Gly Ala Asn 
             20                  25                  30
Gly Glu Ala Glu Ser Gly Glu Leu Ser Arg Leu Arg Ala Glu Leu Ala 
         35                  40                  45
Gly Ala Leu Ala Glu Met Glu Thr Met Lys Ala Val Ala Glu Val Ser 
     50                  55                  60
Glu Ser Thr Lys Ala Glu Ala Val Ala Ala Val Gln Arg Gln Cys Gln 
 65                  70                  75                  80
Glu Glu Val Ala Ser Leu Gln Ala Ile Leu Lys Asp Ser Ile Ser Ser 
                 85                  90                  95
Tyr Glu Ala Gln Ile Thr Ala Leu Lys Gln Glu Arg Gln Gln Gln Gln 
             100                105                110
Gln Asp Cys Glu Glu Lys Glu Arg Glu Leu Gly Arg Leu Lys Gln Leu 
         115                120                125
Leu Ser Arg Ala Tyr Pro Leu Asp Ser Leu Glu Lys Gln Met Glu Lys 
     130                135                140
Ala His Glu Asp Ser Glu Lys Leu Arg Glu Ile Val Leu Pro Met Glu 
 145                150                155                160
Lys Glu Ile Glu Glu Leu Lys Ala Lys Leu Leu Arg Ala Glu Glu Leu 
                 165                170                175
Ile Gln Glu Ile Gln Arg Arg Pro Arg His Ala Pro Ser Leu His Gly 
             180                185                190
Ser Thr Glu Leu Leu Pro Leu Ser Arg Asp Pro Ser Pro Pro Leu Glu 
         195                200                205
Pro Leu Glu Glu Leu Ser Gly Asp Gly Gly Pro Ala Ala Glu Ala Phe 
     210                215                220
Ala His Asn Cys Asp Asp Ser Ala Ser Ile Ser Ser Phe Ser Leu Gly 
 225                230                235                240
Gly Gly Val Gly Ser Ser Ser Ser Leu Pro Gln Ser Arg Gln Gly Leu 
                 245                250                255
Ser Pro Glu Gln Glu Glu Thr Ala Ser Leu Val Ser Thr Gly Thr Leu 
             260                265                270
Val Pro Glu Gly Ile Tyr Leu Pro Pro Pro Gly Tyr Gln Leu Val Pro 
         275                280                285
Asp Thr Gln Trp Glu Gln Leu Gln Thr Glu Gly Arg Gln Leu Gln Lys 
     290                295                300
Asp Leu Glu Ser Val Ser Arg Glu Arg Asp Glu Leu Gln Glu Gly Leu 
 305                310                315                320
Arg Arg Ser Asn Glu Asp Cys Ala Lys Gln Met Gln Val Leu Leu Ala 
                 325                330                335
Gln Val Gln Asn Ser Glu Gln Leu Leu Arg Thr Leu Gln Gly Thr Val 
             340                345                350
Ser Gln Ala Gln Glu Arg Val Gln Leu Gln Met Ala Glu Leu Val Thr 
         355                360                365
Thr His Lys Cys Leu His His Glu Val Lys Arg Leu Asn Glu Glu Asn 
     370                375                380
Gln Gly Leu Arg Ala Glu Gln Leu Pro Ser Ser Ala Pro Gln Gly Ser 
 385                390                395                400
Gln Gln Glu Gln Gly Glu Glu Glu Ser Leu Pro Ser Ser Val Pro Glu 
                 405                410                415
Leu Gln Gln Leu Leu Cys Cys Thr Arg Gln Glu Ala Arg Ala Arg Leu 
             420                425                430
Gln Ala Gln Glu His Gly Ala Glu Arg Leu Arg Ile Glu Ile Val Thr 
         435                440                445
Leu Arg Glu Ala Leu Glu Glu Glu Thr Val Ala Arg Ala Ser Leu Glu 
     450                455                460
Gly Gln Leu Arg Val Gln Arg Glu Glu Thr Glu Val Leu Glu Ala Ser 
 465                470                475                480
Leu Cys Ser Leu Arg Thr Glu Met Glu Arg Val Gln Gln Glu Gln Ser 
                 485                490                495
Lys Ala Gln Leu Pro Asp Leu Leu Ser Glu Gln Arg Ala Lys Val Leu 
             500                505                510
Arg Leu Gln Ala Glu Leu Glu Thr Ser Glu Gln Cys Arg Gly Ile Ser 
         515                520                525
Cys Asp Cys Pro Arg Pro Cys Arg Cys Ala 
     530                535



<210> 8403
<211> 2222
<212> DNA
<213> Rattus norvegicus
<308> U34932
<400> 8403

gcggccgcg  cgacgtgcc  tcaccagtg  gtgcgggaa  ccgccgttt  ggctgagac  60
atggcagct  cgccagcag  cctagcgct  gatccccag  cccaagagg  gcaaaagga  120
gcatccgaa  caagtgagc  cagtaggct  cgtgccgaa  tggccggtg  actggcaga  180
atggaaacc  tgaaggctg  agctgaggt  agcgagagc  ccaaggcag  ggcggtggc  240
gcagtgcag  gacagtgcc  agaggaggt  gcttccctg  aggccatcc  gaaagactc  300
atcagcagc  acgagaccc  gatcgcagc  ctgaaacag  agcggcagc  gcagcaaca  360
gactctgag  agaaggagc  agagctggg  cacctcaaa  agctgctgg  ccgggccca  420
cctttggac  ccttggaga  gcaaatgga  aaggctcac  aagactcag  aaagcttcg  480
gagatcgtg  tgcccatgg  gcaggagat  gcagagctg  aggtgaagc  gctgagggc  540
gaagagctg  tccaagaga  ccagagacg  ccaaggcag  ctgcctccc  gcatggctc  600
acagagttg  ttccactat  aaggaaccc  tcaccacca  tggaaccct  ggaggaacc  660
agtggagac  caggcccag  tgctgaggc  ttcgcccac  actgtgatg  cagtgcctc  720
atctcttcc  tctccctcg  tggggccgc  ggtagtgtc  ccctacgag  tccccaagg  780
ctcagcccc  agcaggaag  gacagcttc  ctggtgtct  ctggcactc  ggtccccga  840
ggcatctac  taccccctc  ggggtacca  cttgttcca  acagccagt  ggagcaact  900
caggtagag  ggcggcagc  gcagaagga  ctggaaagt  tccgccgtg  gcgggatga  960
ctgcaggaa  gactgagcc  gagcaatga  gactgtgcc  agcagatgc  ggtgctcct  1020
gcccaggtc  agaactcag  gcagctgct  cgaactctg  agggaaccg  gagccaggc  1080
caggagcgg  tgcagcggc  gatggcaga  ctggccact  ctcacaagt  cctgagcca  1140
gaggttaaa  gactgaatg  agaaaatcg  ggactccgg  ctgagcagc  gccatcctc  1200
gccctccag  gctcagagc  gcaggagga  caggacgag  ccctgccaa  ctccataca  1260
gagctacac  agctggtgc  gcacacccg  cagcaggct  gggccaggc  gcaggcaca  1320
gagcatgag  ctgagcgcc  gcgcattga  attgtgaag  tgcgggagg  actagacga  1380
gagacagca  ccaaggcca  tctggaggg  cagctgagg  tgcagcgag  agagacaga  1440
gtgctggag  cctccctgt  cagcctgag  atagagaca  agcgggtcc  acaagagca  1500
cacaaggcc  agctcacag  tctcctctc  gaacagaga  ccaaggcac  acggctgca  1560
gctgagctg  agaccagtg  acaggtgca  agggacttc  tacggctat  ccaggccct  1620
caggtgcgc  tggagcaga  ccgccaagc  gacactctg  agcaagtac  tagcattct  1680
gacgaggca  ccctcaggg  cattaagga  attaaggac  cgtgagggg  caggcgaga  1740
gcctccctg  tggggaagc  gccccattc  ctaccagaa  tgtgaggtg  tgactgcag  1800
tctcagaat  gagtccgtc  gctgcaaac  tggacagtg  tgtcccggg  cactacttc  1860
acccagggt  gctggccct  ccctcaggg  tgatacctg  aagagggtc  tagcctcct  1920
ccagaacca  agctttcag  ctgccatgc  ccctcatgg  tccagttct  ccaccccgt  1980
acctcgggc  agcagccag  cccactctc  gcgtaccca  cttatggct  gaagctgtt  2040
gattcagtg  ctcctcaca  agaggccct  ggacacaca  ctgctttct  gactgtatg  2100
cactaaggt  tttgtccat  ggtacccga  ataggcccc  agacataag  aagcaaggc  2160
agacttttc  gtcatttat  ttcaataaa  aagcagtca  ctaaaaaaa  aaaaaaaaa  2220
aa  2222



<210> 8404
<211> 554
<212> PRT
<213> Rattus norvegicus
<308> AAA79137
<400> 8404

Met Ala Ala Ala Pro Ala Ala Leu Ala Leu Asp Pro Gln Pro Gln Glu 
  1               5                  10                  15
Glu Gln Lys Asp Ala Ser Glu Ser Ser Glu Leu Ser Arg Leu Arg Ala 
             20                  25                  30
Glu Leu Ala Gly Ala Leu Ala Glu Met Glu Thr Met Lys Ala Val Ala 
         35                  40                  45
Glu Val Ser Glu Ser Thr Lys Ala Glu Ala Val Ala Ala Val Gln Arg 
     50                  55                  60
Gln Cys Gln Glu Glu Val Ala Ser Leu Gln Ala Ile Leu Lys Asp Ser 
 65                  70                  75                  80
Ile Ser Ser Tyr Glu Thr Gln Ile Ala Ala Leu Lys Gln Glu Arg Gln 
                 85                  90                  95
Gln Gln Gln Gln Asp Ser Glu Glu Lys Glu Arg Glu Leu Gly His Leu 
             100                105                110
Lys Gln Leu Leu Ala Arg Ala His Pro Leu Asp Ser Leu Glu Lys Gln 
         115                120                125
Met Glu Lys Ala His Glu Asp Ser Glu Lys Leu Arg Glu Ile Val Leu 
     130                135                140
Pro Met Glu Gln Glu Ile Ala Glu Leu Lys Val Lys Leu Leu Arg Ala 
 145                150                155                160
Glu Glu Leu Ile Gln Glu Ile Gln Arg Arg Pro Arg Gln Pro Ala Ser 
                 165                170                175
Leu His Gly Ser Thr Glu Leu Leu Pro Leu Ser Arg Asn Pro Ser Pro 
             180                185                190
Pro Leu Glu Pro Ser Glu Glu Pro Ser Gly Asp Ala Gly Pro Ala Ala 
         195                200                205
Glu Ala Phe Ala His Asn Cys Asp Asp Ser Ala Ser Ile Ser Ser Phe 
     210                215                220
Ser Leu Gly Gly Ala Ala Gly Ser Val Ser Leu Arg Gly Pro Gln Gly 
 225                230                235                240
Leu Ser Pro Glu Gln Glu Glu Thr Ala Ser Leu Val Ser Thr Gly Thr 
                 245                250                255
Leu Val Pro Glu Gly Ile Tyr Leu Pro Pro Pro Gly Tyr Gln Leu Val 
             260                265                270
Pro Asp Ser Gln Trp Glu Gln Leu Gln Val Glu Gly Arg Gln Leu Gln 
         275                280                285
Lys Glu Leu Glu Ser Val Arg Arg Glu Arg Asp Glu Leu Gln Glu Gly 
     290                295                300
Leu Ser Arg Ser Asn Glu Asp Cys Ala Lys Gln Met Gln Val Leu Leu 
 305                310                315                320
Ala Gln Val Gln Asn Ser Glu Gln Leu Leu Arg Thr Leu Gln Gly Thr 
                 325                330                335
Val Ser Gln Ala Gln Glu Arg Val Gln Arg Gln Met Ala Glu Leu Ala 
             340                345                350
Thr Ser His Lys Cys Leu Ser Gln Glu Val Lys Arg Leu Asn Glu Glu 
         355                360                365
Asn Arg Gly Leu Arg Ala Glu Gln Leu Pro Ser Ser Ala Leu Gln Gly 
     370                375                380
Ser Glu Gln Gln Glu Asp Gln Asp Glu Ala Leu Pro Ser Ser Ile Gln 
 385                390                395                400
Glu Leu His Gln Leu Val Arg His Thr Arg Gln Gln Ala Arg Ala Arg 
                 405                410                415
Gln Gln Ala Gln Glu His Glu Ala Glu Arg Leu Arg Ile Glu Ile Val 
             420                425                430
Lys Leu Arg Glu Ala Leu Asp Glu Glu Thr Ala Ala Lys Ala Ser Leu 
         435                440                445
Glu Gly Gln Leu Arg Val Gln Arg Glu Glu Thr Asp Val Leu Glu Ala 
     450                455                460
Ser Leu Cys Ser Leu Arg Ile Glu Thr Glu Arg Val Gln Gln Glu His 
 465                470                475                480
His Lys Ala Gln Leu Thr Asp Leu Leu Ser Glu Gln Arg Ala Lys Ala 
                 485                490                495
Leu Arg Leu Gln Ala Glu Leu Glu Thr Ser Glu Gln Val Gln Arg Asp 
             500                505                510
Phe Val Arg Leu Ser Gln Ala Leu Gln Val Arg Leu Glu Gln Ile Arg 
         515                520                525
Gln Ala Asp Thr Leu Glu Gln Val Arg Ser Ile Leu Asp Glu Ala Pro 
     530                535                540
Leu Arg Asp Ile Lys Asp Ile Lys Asp Ser 
 545                550



<210> 8405
<211> 2309
<212> DNA
<213> Homo sapiens
<308> NM_024816
<400> 8405

gcgctccgt  accagggag  gcgggaatc  gccgtttgc  ctgaggcaa  ggcggcagc  60
gcgccggtg  ccgcggacg  cgatgagcg  cggcggcgg  cgggggctg  actggagga  120
tcccggtcc  aggaagggg  aaatggtga  gccgagtca  gtgagctca  ccggcttcg  180
gctgagctg  caggcgccc  ggcagaaat  gaaaccatg  aggctgtgg  agaggtgag  240
gagagcacg  aggccgagg  tgtggctgc  gtgcagcgg  agtgccaag  ggaggtggc  300
tcgctgcag  ccatcctga  agactccat  agcagctat  aagcccaga  caccgccct  360
aagcaggag  gacagcagc  gcagcagga  tgtgaggag  aggagcggg  gctgggccg  420
ctgaagcag  tgctgtccc  ggcctaccc  ctggactcc  tggagaagc  gatggaaaa  480
gcccacgag  actcggaga  gctgcggga  atcgtactg  ccatggaaa  ggagatcga  540
gagctgaag  cgaagctgc  gagggccga  gagctgatt  aggagatcc  gagacgtcc  600
cggcatgcc  cttccctgc  cggctccac  gagttgctg  ccctgtccc  ggatccatc  660
cccccgctg  agcctctgg  ggagctgag  ggagatggg  gtccagccg  tgaggcctt  720
gctcacaac  gcgatgaca  cgcctccat  tcctccttc  cccttggcg  tggggtcgg  780
agcagctcc  ccctgcccc  aagccgcca  ggcctgagc  ctgaacagg  agagacggc  840
tcgctggtg  ctacgggca  cctggttcc  gagggcatc  acctgcccc  tcctggcta  900
cagctcgtc  cagacactc  gtgggagca  ctgcagaca  agggccgac  gctgcagaa  960
gacctggag  gcgtcagtc  cgagcggga  gagctccaa  agggcctga  acggagcaa  1020
gaggactgt  ccaagcaga  gcaggtgct  ctggcccag  tccagaact  agagcagct  1080
ctgcggacc  tgcaaggga  cgtgagcca  gcccaggag  gggtgcagc  gcagatggc  1140
gagctggtc  ccacccaca  gtgcctgca  catgaggta  agcggttga  tgaggaaaa  1200
caagggctc  gggccgagc  gctgccatc  tcagccccc  agggctcgc  gcaggagca  1260
ggcgaggag  aatcactgc  cagctctgt  ccagagctg  agcagctgc  gtgctgcac  1320
cggcaagag  cgagggccc  gctgcaggc  caggagcac  gggccgagc  cctgcggat  1380
gagatcgtg  cgctgcggg  ggctctgga  gaggagaca  tggccaggg  cagcctgga  1440
gggcagctg  gggtgcagc  ggaggagac  gaggtgctg  aggcctccc  gtgcagcct  1500
aggacagag  tggagcggg  gcagcagga  cagagcaag  cccagctcc  agacctcct  1560
tcagaacag  gggccaagg  gctgcggct  caggcagag  tggagacca  tgagcagtg  1620
agagggatt  cgtgcgact  tcccaggcc  tgcaggtgc  cctagagcg  atccgccag  1680
ctgagaccc  ggagcaagt  cgcagcatc  tggatgagg  gccactcac  gacgtcagg  1740
acatcaagg  cacctgagg  gtcaggata  ccccacccc  accctggga  agacgcctt  1800
ccccactcc  gaaccatga  gcctcgctc  ggggtcttg  atggctttt  caccgtccc  1860
gagactggg  ttgagggga  tgacggggg  caccaccgc  ccgccctcc  gcgcctcct  1920
ccagggtgg  tgggcctcc  gttctcagg  gtcacacct  ggtgagggg  ccaagcccc  1980
cccggaacc  aaggtgcag  ctcaggcct  cggctttct  gctgctgtg  tgcctcctg  2040
gctccagcc  tcccctgcc  ccagcccgt  ccctgccca  ggcacagcg  agccatggg  2100
gctgggagt  cccatcaga  gcagtgagg  gggccccgg  cctgggaca  gcagctgcc  2160
tctggtctg  atgacacta  gacgcttgt  cacagcggc  acccagacc  ccaagcttg  2220
acagaggca  ggccagact  ttccgtcgt  tattttcaa  aaataagca  ctcagcgca  2280
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2309



<210> 8406
<211> 538
<212> PRT
<213> Homo sapiens
<308> NP_079092
<400> 8406

Met Ala Ala Ala Ala Pro Val Ala Ala Asp Asp Asp Glu Arg Arg Arg 
  1               5                  10                  15
Arg Pro Gly Ala Ala Leu Glu Asp Ser Arg Ser Gln Glu Gly Ala Asn 
             20                  25                  30
Gly Glu Ala Glu Ser Gly Glu Leu Ser Arg Leu Arg Ala Glu Leu Ala 
         35                  40                  45
Gly Ala Leu Ala Glu Met Glu Thr Met Lys Ala Val Ala Glu Val Ser 
     50                  55                  60
Glu Ser Thr Lys Ala Glu Ala Val Ala Ala Val Gln Arg Gln Cys Gln 
 65                  70                  75                  80
Glu Glu Val Ala Ser Leu Gln Ala Ile Leu Lys Asp Ser Ile Ser Ser 
                 85                  90                  95
Tyr Glu Ala Gln Ile Thr Ala Leu Lys Gln Glu Arg Gln Gln Gln Gln 
             100                105                110
Gln Asp Cys Glu Glu Lys Glu Arg Glu Leu Gly Arg Leu Lys Gln Leu 
         115                120                125
Leu Ser Arg Ala Tyr Pro Leu Asp Ser Leu Glu Lys Gln Met Glu Lys 
     130                135                140
Ala His Glu Asp Ser Glu Lys Leu Arg Glu Ile Val Leu Pro Met Glu 
 145                150                155                160
Lys Glu Ile Glu Glu Leu Lys Ala Lys Leu Leu Arg Ala Glu Glu Leu 
                 165                170                175
Ile Gln Glu Ile Gln Arg Arg Pro Arg His Ala Pro Ser Leu His Gly 
             180                185                190
Ser Thr Glu Leu Leu Pro Leu Ser Arg Asp Pro Ser Pro Pro Leu Glu 
         195                200                205
Pro Leu Glu Glu Leu Ser Gly Asp Gly Gly Pro Ala Ala Glu Ala Phe 
     210                215                220
Ala His Asn Cys Asp Asp Ser Ala Ser Ile Ser Ser Phe Ser Leu Gly 
 225                230                235                240
Gly Gly Val Gly Ser Ser Ser Ser Leu Pro Gln Ser Arg Gln Gly Leu 
                 245                250                255
Ser Pro Glu Gln Glu Glu Thr Ala Ser Leu Val Ser Thr Gly Thr Leu 
             260                265                270
Val Pro Glu Gly Ile Tyr Leu Pro Pro Pro Gly Tyr Gln Leu Val Pro 
         275                280                285
Asp Thr Gln Trp Glu Gln Leu Gln Thr Glu Gly Arg Gln Leu Gln Lys 
     290                295                300
Asp Leu Glu Ser Val Ser Arg Glu Arg Asp Glu Leu Gln Glu Gly Leu 
 305                310                315                320
Arg Arg Ser Asn Glu Asp Cys Ala Lys Gln Met Gln Val Leu Leu Ala 
                 325                330                335
Gln Val Gln Asn Ser Glu Gln Leu Leu Arg Thr Leu Gln Gly Thr Val 
             340                345                350
Ser Gln Ala Gln Glu Arg Val Gln Leu Gln Met Ala Glu Leu Val Thr 
         355                360                365
Thr His Lys Cys Leu His His Glu Val Lys Arg Leu Asn Glu Glu Asn 
     370                375                380
Gln Gly Leu Arg Ala Glu Gln Leu Pro Ser Ser Ala Pro Gln Gly Ser 
 385                390                395                400
Gln Gln Glu Gln Gly Glu Glu Glu Ser Leu Pro Ser Ser Val Pro Glu 
                 405                410                415
Leu Gln Gln Leu Leu Cys Cys Thr Arg Gln Glu Ala Arg Ala Arg Leu 
             420                425                430
Gln Ala Gln Glu His Gly Ala Glu Arg Leu Arg Ile Glu Ile Val Thr 
         435                440                445
Leu Arg Glu Ala Leu Glu Glu Glu Thr Val Ala Arg Ala Ser Leu Glu 
     450                455                460
Gly Gln Leu Arg Val Gln Arg Glu Glu Thr Glu Val Leu Glu Ala Ser 
 465                470                475                480
Leu Cys Ser Leu Arg Thr Glu Met Glu Arg Val Gln Gln Glu Gln Ser 
                 485                490                495
Lys Ala Gln Leu Pro Asp Leu Leu Ser Glu Gln Arg Ala Lys Val Leu 
             500                505                510
Arg Leu Gln Ala Glu Leu Glu Thr Ser Glu Gln Cys Arg Gly Ile Ser 
         515                520                525
Cys Asp Cys Pro Arg Pro Cys Arg Cys Ala 
     530                535



<210> 8407
<211> 2222
<212> DNA
<213> Rattus norvegicus
<308> U34932
<400> 8407

gcggccgcg  cgacgtgcc  tcaccagtg  gtgcgggaa  ccgccgttt  ggctgagac  60
atggcagct  cgccagcag  cctagcgct  gatccccag  cccaagagg  gcaaaagga  120
gcatccgaa  caagtgagc  cagtaggct  cgtgccgaa  tggccggtg  actggcaga  180
atggaaacc  tgaaggctg  agctgaggt  agcgagagc  ccaaggcag  ggcggtggc  240
gcagtgcag  gacagtgcc  agaggaggt  gcttccctg  aggccatcc  gaaagactc  300
atcagcagc  acgagaccc  gatcgcagc  ctgaaacag  agcggcagc  gcagcaaca  360
gactctgag  agaaggagc  agagctggg  cacctcaaa  agctgctgg  ccgggccca  420
cctttggac  ccttggaga  gcaaatgga  aaggctcac  aagactcag  aaagcttcg  480
gagatcgtg  tgcccatgg  gcaggagat  gcagagctg  aggtgaagc  gctgagggc  540
gaagagctg  tccaagaga  ccagagacg  ccaaggcag  ctgcctccc  gcatggctc  600
acagagttg  ttccactat  aaggaaccc  tcaccacca  tggaaccct  ggaggaacc  660
agtggagac  caggcccag  tgctgaggc  ttcgcccac  actgtgatg  cagtgcctc  720
atctcttcc  tctccctcg  tggggccgc  ggtagtgtc  ccctacgag  tccccaagg  780
ctcagcccc  agcaggaag  gacagcttc  ctggtgtct  ctggcactc  ggtccccga  840
ggcatctac  taccccctc  ggggtacca  cttgttcca  acagccagt  ggagcaact  900
caggtagag  ggcggcagc  gcagaagga  ctggaaagt  tccgccgtg  gcgggatga  960
ctgcaggaa  gactgagcc  gagcaatga  gactgtgcc  agcagatgc  ggtgctcct  1020
gcccaggtc  agaactcag  gcagctgct  cgaactctg  agggaaccg  gagccaggc  1080
caggagcgg  tgcagcggc  gatggcaga  ctggccact  ctcacaagt  cctgagcca  1140
gaggttaaa  gactgaatg  agaaaatcg  ggactccgg  ctgagcagc  gccatcctc  1200
gccctccag  gctcagagc  gcaggagga  caggacgag  ccctgccaa  ctccataca  1260
gagctacac  agctggtgc  gcacacccg  cagcaggct  gggccaggc  gcaggcaca  1320
gagcatgag  ctgagcgcc  gcgcattga  attgtgaag  tgcgggagg  actagacga  1380
gagacagca  ccaaggcca  tctggaggg  cagctgagg  tgcagcgag  agagacaga  1440
gtgctggag  cctccctgt  cagcctgag  atagagaca  agcgggtcc  acaagagca  1500
cacaaggcc  agctcacag  tctcctctc  gaacagaga  ccaaggcac  acggctgca  1560
gctgagctg  agaccagtg  acaggtgca  agggacttc  tacggctat  ccaggccct  1620
caggtgcgc  tggagcaga  ccgccaagc  gacactctg  agcaagtac  tagcattct  1680
gacgaggca  ccctcaggg  cattaagga  attaaggac  cgtgagggg  caggcgaga  1740
gcctccctg  tggggaagc  gccccattc  ctaccagaa  tgtgaggtg  tgactgcag  1800
tctcagaat  gagtccgtc  gctgcaaac  tggacagtg  tgtcccggg  cactacttc  1860
acccagggt  gctggccct  ccctcaggg  tgatacctg  aagagggtc  tagcctcct  1920
ccagaacca  agctttcag  ctgccatgc  ccctcatgg  tccagttct  ccaccccgt  1980
acctcgggc  agcagccag  cccactctc  gcgtaccca  cttatggct  gaagctgtt  2040
gattcagtg  ctcctcaca  agaggccct  ggacacaca  ctgctttct  gactgtatg  2100
cactaaggt  tttgtccat  ggtacccga  ataggcccc  agacataag  aagcaaggc  2160
agacttttc  gtcatttat  ttcaataaa  aagcagtca  ctaaaaaaa  aaaaaaaaa  2220
aa  2222



<210> 8408
<211> 554
<212> PRT
<213> Rattus norvegicus
<308> AAA79137
<400> 8408

Met Ala Ala Ala Pro Ala Ala Leu Ala Leu Asp Pro Gln Pro Gln Glu 
  1               5                  10                  15
Glu Gln Lys Asp Ala Ser Glu Ser Ser Glu Leu Ser Arg Leu Arg Ala 
             20                  25                  30
Glu Leu Ala Gly Ala Leu Ala Glu Met Glu Thr Met Lys Ala Val Ala 
         35                  40                  45
Glu Val Ser Glu Ser Thr Lys Ala Glu Ala Val Ala Ala Val Gln Arg 
     50                  55                  60
Gln Cys Gln Glu Glu Val Ala Ser Leu Gln Ala Ile Leu Lys Asp Ser 
 65                  70                  75                  80
Ile Ser Ser Tyr Glu Thr Gln Ile Ala Ala Leu Lys Gln Glu Arg Gln 
                 85                  90                  95
Gln Gln Gln Gln Asp Ser Glu Glu Lys Glu Arg Glu Leu Gly His Leu 
             100                105                110
Lys Gln Leu Leu Ala Arg Ala His Pro Leu Asp Ser Leu Glu Lys Gln 
         115                120                125
Met Glu Lys Ala His Glu Asp Ser Glu Lys Leu Arg Glu Ile Val Leu 
     130                135                140
Pro Met Glu Gln Glu Ile Ala Glu Leu Lys Val Lys Leu Leu Arg Ala 
 145                150                155                160
Glu Glu Leu Ile Gln Glu Ile Gln Arg Arg Pro Arg Gln Pro Ala Ser 
                 165                170                175
Leu His Gly Ser Thr Glu Leu Leu Pro Leu Ser Arg Asn Pro Ser Pro 
             180                185                190
Pro Leu Glu Pro Ser Glu Glu Pro Ser Gly Asp Ala Gly Pro Ala Ala 
         195                200                205
Glu Ala Phe Ala His Asn Cys Asp Asp Ser Ala Ser Ile Ser Ser Phe 
     210                215                220
Ser Leu Gly Gly Ala Ala Gly Ser Val Ser Leu Arg Gly Pro Gln Gly 
 225                230                235                240
Leu Ser Pro Glu Gln Glu Glu Thr Ala Ser Leu Val Ser Thr Gly Thr 
                 245                250                255
Leu Val Pro Glu Gly Ile Tyr Leu Pro Pro Pro Gly Tyr Gln Leu Val 
             260                265                270
Pro Asp Ser Gln Trp Glu Gln Leu Gln Val Glu Gly Arg Gln Leu Gln 
         275                280                285
Lys Glu Leu Glu Ser Val Arg Arg Glu Arg Asp Glu Leu Gln Glu Gly 
     290                295                300
Leu Ser Arg Ser Asn Glu Asp Cys Ala Lys Gln Met Gln Val Leu Leu 
 305                310                315                320
Ala Gln Val Gln Asn Ser Glu Gln Leu Leu Arg Thr Leu Gln Gly Thr 
                 325                330                335
Val Ser Gln Ala Gln Glu Arg Val Gln Arg Gln Met Ala Glu Leu Ala 
             340                345                350
Thr Ser His Lys Cys Leu Ser Gln Glu Val Lys Arg Leu Asn Glu Glu 
         355                360                365
Asn Arg Gly Leu Arg Ala Glu Gln Leu Pro Ser Ser Ala Leu Gln Gly 
     370                375                380
Ser Glu Gln Gln Glu Asp Gln Asp Glu Ala Leu Pro Ser Ser Ile Gln 
 385                390                395                400
Glu Leu His Gln Leu Val Arg His Thr Arg Gln Gln Ala Arg Ala Arg 
                 405                410                415
Gln Gln Ala Gln Glu His Glu Ala Glu Arg Leu Arg Ile Glu Ile Val 
             420                425                430
Lys Leu Arg Glu Ala Leu Asp Glu Glu Thr Ala Ala Lys Ala Ser Leu 
         435                440                445
Glu Gly Gln Leu Arg Val Gln Arg Glu Glu Thr Asp Val Leu Glu Ala 
     450                455                460
Ser Leu Cys Ser Leu Arg Ile Glu Thr Glu Arg Val Gln Gln Glu His 
 465                470                475                480
His Lys Ala Gln Leu Thr Asp Leu Leu Ser Glu Gln Arg Ala Lys Ala 
                 485                490                495
Leu Arg Leu Gln Ala Glu Leu Glu Thr Ser Glu Gln Val Gln Arg Asp 
             500                505                510
Phe Val Arg Leu Ser Gln Ala Leu Gln Val Arg Leu Glu Gln Ile Arg 
         515                520                525
Gln Ala Asp Thr Leu Glu Gln Val Arg Ser Ile Leu Asp Glu Ala Pro 
     530                535                540
Leu Arg Asp Ile Lys Asp Ile Lys Asp Ser 
 545                550



<210> 8409
<211> 2309
<212> DNA
<213> Homo sapiens
<308> NM_024816
<400> 8409

gcgctccgt  accagggag  gcgggaatc  gccgtttgc  ctgaggcaa  ggcggcagc  60
gcgccggtg  ccgcggacg  cgatgagcg  cggcggcgg  cgggggctg  actggagga  120
tcccggtcc  aggaagggg  aaatggtga  gccgagtca  gtgagctca  ccggcttcg  180
gctgagctg  caggcgccc  ggcagaaat  gaaaccatg  aggctgtgg  agaggtgag  240
gagagcacg  aggccgagg  tgtggctgc  gtgcagcgg  agtgccaag  ggaggtggc  300
tcgctgcag  ccatcctga  agactccat  agcagctat  aagcccaga  caccgccct  360
aagcaggag  gacagcagc  gcagcagga  tgtgaggag  aggagcggg  gctgggccg  420
ctgaagcag  tgctgtccc  ggcctaccc  ctggactcc  tggagaagc  gatggaaaa  480
gcccacgag  actcggaga  gctgcggga  atcgtactg  ccatggaaa  ggagatcga  540
gagctgaag  cgaagctgc  gagggccga  gagctgatt  aggagatcc  gagacgtcc  600
cggcatgcc  cttccctgc  cggctccac  gagttgctg  ccctgtccc  ggatccatc  660
cccccgctg  agcctctgg  ggagctgag  ggagatggg  gtccagccg  tgaggcctt  720
gctcacaac  gcgatgaca  cgcctccat  tcctccttc  cccttggcg  tggggtcgg  780
agcagctcc  ccctgcccc  aagccgcca  ggcctgagc  ctgaacagg  agagacggc  840
tcgctggtg  ctacgggca  cctggttcc  gagggcatc  acctgcccc  tcctggcta  900
cagctcgtc  cagacactc  gtgggagca  ctgcagaca  agggccgac  gctgcagaa  960
gacctggag  gcgtcagtc  cgagcggga  gagctccaa  agggcctga  acggagcaa  1020
gaggactgt  ccaagcaga  gcaggtgct  ctggcccag  tccagaact  agagcagct  1080
ctgcggacc  tgcaaggga  cgtgagcca  gcccaggag  gggtgcagc  gcagatggc  1140
gagctggtc  ccacccaca  gtgcctgca  catgaggta  agcggttga  tgaggaaaa  1200
caagggctc  gggccgagc  gctgccatc  tcagccccc  agggctcgc  gcaggagca  1260
ggcgaggag  aatcactgc  cagctctgt  ccagagctg  agcagctgc  gtgctgcac  1320
cggcaagag  cgagggccc  gctgcaggc  caggagcac  gggccgagc  cctgcggat  1380
gagatcgtg  cgctgcggg  ggctctgga  gaggagaca  tggccaggg  cagcctgga  1440
gggcagctg  gggtgcagc  ggaggagac  gaggtgctg  aggcctccc  gtgcagcct  1500
aggacagag  tggagcggg  gcagcagga  cagagcaag  cccagctcc  agacctcct  1560
tcagaacag  gggccaagg  gctgcggct  caggcagag  tggagacca  tgagcagtg  1620
agagggatt  cgtgcgact  tcccaggcc  tgcaggtgc  cctagagcg  atccgccag  1680
ctgagaccc  ggagcaagt  cgcagcatc  tggatgagg  gccactcac  gacgtcagg  1740
acatcaagg  cacctgagg  gtcaggata  ccccacccc  accctggga  agacgcctt  1800
ccccactcc  gaaccatga  gcctcgctc  ggggtcttg  atggctttt  caccgtccc  1860
gagactggg  ttgagggga  tgacggggg  caccaccgc  ccgccctcc  gcgcctcct  1920
ccagggtgg  tgggcctcc  gttctcagg  gtcacacct  ggtgagggg  ccaagcccc  1980
cccggaacc  aaggtgcag  ctcaggcct  cggctttct  gctgctgtg  tgcctcctg  2040
gctccagcc  tcccctgcc  ccagcccgt  ccctgccca  ggcacagcg  agccatggg  2100
gctgggagt  cccatcaga  gcagtgagg  gggccccgg  cctgggaca  gcagctgcc  2160
tctggtctg  atgacacta  gacgcttgt  cacagcggc  acccagacc  ccaagcttg  2220
acagaggca  ggccagact  ttccgtcgt  tattttcaa  aaataagca  ctcagcgca  2280
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2309



<210> 8410
<211> 538
<212> PRT
<213> Homo sapiens
<308> NP_079092
<400> 8410

Met Ala Ala Ala Ala Pro Val Ala Ala Asp Asp Asp Glu Arg Arg Arg 
  1               5                  10                  15
Arg Pro Gly Ala Ala Leu Glu Asp Ser Arg Ser Gln Glu Gly Ala Asn 
             20                  25                  30
Gly Glu Ala Glu Ser Gly Glu Leu Ser Arg Leu Arg Ala Glu Leu Ala 
         35                  40                  45
Gly Ala Leu Ala Glu Met Glu Thr Met Lys Ala Val Ala Glu Val Ser 
     50                  55                  60
Glu Ser Thr Lys Ala Glu Ala Val Ala Ala Val Gln Arg Gln Cys Gln 
 65                  70                  75                  80
Glu Glu Val Ala Ser Leu Gln Ala Ile Leu Lys Asp Ser Ile Ser Ser 
                 85                  90                  95
Tyr Glu Ala Gln Ile Thr Ala Leu Lys Gln Glu Arg Gln Gln Gln Gln 
             100                105                110
Gln Asp Cys Glu Glu Lys Glu Arg Glu Leu Gly Arg Leu Lys Gln Leu 
         115                120                125
Leu Ser Arg Ala Tyr Pro Leu Asp Ser Leu Glu Lys Gln Met Glu Lys 
     130                135                140
Ala His Glu Asp Ser Glu Lys Leu Arg Glu Ile Val Leu Pro Met Glu 
 145                150                155                160
Lys Glu Ile Glu Glu Leu Lys Ala Lys Leu Leu Arg Ala Glu Glu Leu 
                 165                170                175
Ile Gln Glu Ile Gln Arg Arg Pro Arg His Ala Pro Ser Leu His Gly 
             180                185                190
Ser Thr Glu Leu Leu Pro Leu Ser Arg Asp Pro Ser Pro Pro Leu Glu 
         195                200                205
Pro Leu Glu Glu Leu Ser Gly Asp Gly Gly Pro Ala Ala Glu Ala Phe 
     210                215                220
Ala His Asn Cys Asp Asp Ser Ala Ser Ile Ser Ser Phe Ser Leu Gly 
 225                230                235                240
Gly Gly Val Gly Ser Ser Ser Ser Leu Pro Gln Ser Arg Gln Gly Leu 
                 245                250                255
Ser Pro Glu Gln Glu Glu Thr Ala Ser Leu Val Ser Thr Gly Thr Leu 
             260                265                270
Val Pro Glu Gly Ile Tyr Leu Pro Pro Pro Gly Tyr Gln Leu Val Pro 
         275                280                285
Asp Thr Gln Trp Glu Gln Leu Gln Thr Glu Gly Arg Gln Leu Gln Lys 
     290                295                300
Asp Leu Glu Ser Val Ser Arg Glu Arg Asp Glu Leu Gln Glu Gly Leu 
 305                310                315                320
Arg Arg Ser Asn Glu Asp Cys Ala Lys Gln Met Gln Val Leu Leu Ala 
                 325                330                335
Gln Val Gln Asn Ser Glu Gln Leu Leu Arg Thr Leu Gln Gly Thr Val 
             340                345                350
Ser Gln Ala Gln Glu Arg Val Gln Leu Gln Met Ala Glu Leu Val Thr 
         355                360                365
Thr His Lys Cys Leu His His Glu Val Lys Arg Leu Asn Glu Glu Asn 
     370                375                380
Gln Gly Leu Arg Ala Glu Gln Leu Pro Ser Ser Ala Pro Gln Gly Ser 
 385                390                395                400
Gln Gln Glu Gln Gly Glu Glu Glu Ser Leu Pro Ser Ser Val Pro Glu 
                 405                410                415
Leu Gln Gln Leu Leu Cys Cys Thr Arg Gln Glu Ala Arg Ala Arg Leu 
             420                425                430
Gln Ala Gln Glu His Gly Ala Glu Arg Leu Arg Ile Glu Ile Val Thr 
         435                440                445
Leu Arg Glu Ala Leu Glu Glu Glu Thr Val Ala Arg Ala Ser Leu Glu 
     450                455                460
Gly Gln Leu Arg Val Gln Arg Glu Glu Thr Glu Val Leu Glu Ala Ser 
 465                470                475                480
Leu Cys Ser Leu Arg Thr Glu Met Glu Arg Val Gln Gln Glu Gln Ser 
                 485                490                495
Lys Ala Gln Leu Pro Asp Leu Leu Ser Glu Gln Arg Ala Lys Val Leu 
             500                505                510
Arg Leu Gln Ala Glu Leu Glu Thr Ser Glu Gln Cys Arg Gly Ile Ser 
         515                520                525
Cys Asp Cys Pro Arg Pro Cys Arg Cys Ala 
     530                535



<210> 8411
<211> 2222
<212> DNA
<213> Rattus norvegicus
<308> U34932
<400> 8411

gcggccgcg  cgacgtgcc  tcaccagtg  gtgcgggaa  ccgccgttt  ggctgagac  60
atggcagct  cgccagcag  cctagcgct  gatccccag  cccaagagg  gcaaaagga  120
gcatccgaa  caagtgagc  cagtaggct  cgtgccgaa  tggccggtg  actggcaga  180
atggaaacc  tgaaggctg  agctgaggt  agcgagagc  ccaaggcag  ggcggtggc  240
gcagtgcag  gacagtgcc  agaggaggt  gcttccctg  aggccatcc  gaaagactc  300
atcagcagc  acgagaccc  gatcgcagc  ctgaaacag  agcggcagc  gcagcaaca  360
gactctgag  agaaggagc  agagctggg  cacctcaaa  agctgctgg  ccgggccca  420
cctttggac  ccttggaga  gcaaatgga  aaggctcac  aagactcag  aaagcttcg  480
gagatcgtg  tgcccatgg  gcaggagat  gcagagctg  aggtgaagc  gctgagggc  540
gaagagctg  tccaagaga  ccagagacg  ccaaggcag  ctgcctccc  gcatggctc  600
acagagttg  ttccactat  aaggaaccc  tcaccacca  tggaaccct  ggaggaacc  660
agtggagac  caggcccag  tgctgaggc  ttcgcccac  actgtgatg  cagtgcctc  720
atctcttcc  tctccctcg  tggggccgc  ggtagtgtc  ccctacgag  tccccaagg  780
ctcagcccc  agcaggaag  gacagcttc  ctggtgtct  ctggcactc  ggtccccga  840
ggcatctac  taccccctc  ggggtacca  cttgttcca  acagccagt  ggagcaact  900
caggtagag  ggcggcagc  gcagaagga  ctggaaagt  tccgccgtg  gcgggatga  960
ctgcaggaa  gactgagcc  gagcaatga  gactgtgcc  agcagatgc  ggtgctcct  1020
gcccaggtc  agaactcag  gcagctgct  cgaactctg  agggaaccg  gagccaggc  1080
caggagcgg  tgcagcggc  gatggcaga  ctggccact  ctcacaagt  cctgagcca  1140
gaggttaaa  gactgaatg  agaaaatcg  ggactccgg  ctgagcagc  gccatcctc  1200
gccctccag  gctcagagc  gcaggagga  caggacgag  ccctgccaa  ctccataca  1260
gagctacac  agctggtgc  gcacacccg  cagcaggct  gggccaggc  gcaggcaca  1320
gagcatgag  ctgagcgcc  gcgcattga  attgtgaag  tgcgggagg  actagacga  1380
gagacagca  ccaaggcca  tctggaggg  cagctgagg  tgcagcgag  agagacaga  1440
gtgctggag  cctccctgt  cagcctgag  atagagaca  agcgggtcc  acaagagca  1500
cacaaggcc  agctcacag  tctcctctc  gaacagaga  ccaaggcac  acggctgca  1560
gctgagctg  agaccagtg  acaggtgca  agggacttc  tacggctat  ccaggccct  1620
caggtgcgc  tggagcaga  ccgccaagc  gacactctg  agcaagtac  tagcattct  1680
gacgaggca  ccctcaggg  cattaagga  attaaggac  cgtgagggg  caggcgaga  1740
gcctccctg  tggggaagc  gccccattc  ctaccagaa  tgtgaggtg  tgactgcag  1800
tctcagaat  gagtccgtc  gctgcaaac  tggacagtg  tgtcccggg  cactacttc  1860
acccagggt  gctggccct  ccctcaggg  tgatacctg  aagagggtc  tagcctcct  1920
ccagaacca  agctttcag  ctgccatgc  ccctcatgg  tccagttct  ccaccccgt  1980
acctcgggc  agcagccag  cccactctc  gcgtaccca  cttatggct  gaagctgtt  2040
gattcagtg  ctcctcaca  agaggccct  ggacacaca  ctgctttct  gactgtatg  2100
cactaaggt  tttgtccat  ggtacccga  ataggcccc  agacataag  aagcaaggc  2160
agacttttc  gtcatttat  ttcaataaa  aagcagtca  ctaaaaaaa  aaaaaaaaa  2220
aa  2222



<210> 8412
<211> 554
<212> PRT
<213> Rattus norvegicus
<308> AAA79137
<400> 8412

Met Ala Ala Ala Pro Ala Ala Leu Ala Leu Asp Pro Gln Pro Gln Glu 
  1               5                  10                  15
Glu Gln Lys Asp Ala Ser Glu Ser Ser Glu Leu Ser Arg Leu Arg Ala 
             20                  25                  30
Glu Leu Ala Gly Ala Leu Ala Glu Met Glu Thr Met Lys Ala Val Ala 
         35                  40                  45
Glu Val Ser Glu Ser Thr Lys Ala Glu Ala Val Ala Ala Val Gln Arg 
     50                  55                  60
Gln Cys Gln Glu Glu Val Ala Ser Leu Gln Ala Ile Leu Lys Asp Ser 
 65                  70                  75                  80
Ile Ser Ser Tyr Glu Thr Gln Ile Ala Ala Leu Lys Gln Glu Arg Gln 
                 85                  90                  95
Gln Gln Gln Gln Asp Ser Glu Glu Lys Glu Arg Glu Leu Gly His Leu 
             100                105                110
Lys Gln Leu Leu Ala Arg Ala His Pro Leu Asp Ser Leu Glu Lys Gln 
         115                120                125
Met Glu Lys Ala His Glu Asp Ser Glu Lys Leu Arg Glu Ile Val Leu 
     130                135                140
Pro Met Glu Gln Glu Ile Ala Glu Leu Lys Val Lys Leu Leu Arg Ala 
 145                150                155                160
Glu Glu Leu Ile Gln Glu Ile Gln Arg Arg Pro Arg Gln Pro Ala Ser 
                 165                170                175
Leu His Gly Ser Thr Glu Leu Leu Pro Leu Ser Arg Asn Pro Ser Pro 
             180                185                190
Pro Leu Glu Pro Ser Glu Glu Pro Ser Gly Asp Ala Gly Pro Ala Ala 
         195                200                205
Glu Ala Phe Ala His Asn Cys Asp Asp Ser Ala Ser Ile Ser Ser Phe 
     210                215                220
Ser Leu Gly Gly Ala Ala Gly Ser Val Ser Leu Arg Gly Pro Gln Gly 
 225                230                235                240
Leu Ser Pro Glu Gln Glu Glu Thr Ala Ser Leu Val Ser Thr Gly Thr 
                 245                250                255
Leu Val Pro Glu Gly Ile Tyr Leu Pro Pro Pro Gly Tyr Gln Leu Val 
             260                265                270
Pro Asp Ser Gln Trp Glu Gln Leu Gln Val Glu Gly Arg Gln Leu Gln 
         275                280                285
Lys Glu Leu Glu Ser Val Arg Arg Glu Arg Asp Glu Leu Gln Glu Gly 
     290                295                300
Leu Ser Arg Ser Asn Glu Asp Cys Ala Lys Gln Met Gln Val Leu Leu 
 305                310                315                320
Ala Gln Val Gln Asn Ser Glu Gln Leu Leu Arg Thr Leu Gln Gly Thr 
                 325                330                335
Val Ser Gln Ala Gln Glu Arg Val Gln Arg Gln Met Ala Glu Leu Ala 
             340                345                350
Thr Ser His Lys Cys Leu Ser Gln Glu Val Lys Arg Leu Asn Glu Glu 
         355                360                365
Asn Arg Gly Leu Arg Ala Glu Gln Leu Pro Ser Ser Ala Leu Gln Gly 
     370                375                380
Ser Glu Gln Gln Glu Asp Gln Asp Glu Ala Leu Pro Ser Ser Ile Gln 
 385                390                395                400
Glu Leu His Gln Leu Val Arg His Thr Arg Gln Gln Ala Arg Ala Arg 
                 405                410                415
Gln Gln Ala Gln Glu His Glu Ala Glu Arg Leu Arg Ile Glu Ile Val 
             420                425                430
Lys Leu Arg Glu Ala Leu Asp Glu Glu Thr Ala Ala Lys Ala Ser Leu 
         435                440                445
Glu Gly Gln Leu Arg Val Gln Arg Glu Glu Thr Asp Val Leu Glu Ala 
     450                455                460
Ser Leu Cys Ser Leu Arg Ile Glu Thr Glu Arg Val Gln Gln Glu His 
 465                470                475                480
His Lys Ala Gln Leu Thr Asp Leu Leu Ser Glu Gln Arg Ala Lys Ala 
                 485                490                495
Leu Arg Leu Gln Ala Glu Leu Glu Thr Ser Glu Gln Val Gln Arg Asp 
             500                505                510
Phe Val Arg Leu Ser Gln Ala Leu Gln Val Arg Leu Glu Gln Ile Arg 
         515                520                525
Gln Ala Asp Thr Leu Glu Gln Val Arg Ser Ile Leu Asp Glu Ala Pro 
     530                535                540
Leu Arg Asp Ile Lys Asp Ile Lys Asp Ser 
 545                550



<210> 8413
<211> 2309
<212> DNA
<213> Homo sapiens
<308> NM_024816
<400> 8413

gcgctccgt  accagggag  gcgggaatc  gccgtttgc  ctgaggcaa  ggcggcagc  60
gcgccggtg  ccgcggacg  cgatgagcg  cggcggcgg  cgggggctg  actggagga  120
tcccggtcc  aggaagggg  aaatggtga  gccgagtca  gtgagctca  ccggcttcg  180
gctgagctg  caggcgccc  ggcagaaat  gaaaccatg  aggctgtgg  agaggtgag  240
gagagcacg  aggccgagg  tgtggctgc  gtgcagcgg  agtgccaag  ggaggtggc  300
tcgctgcag  ccatcctga  agactccat  agcagctat  aagcccaga  caccgccct  360
aagcaggag  gacagcagc  gcagcagga  tgtgaggag  aggagcggg  gctgggccg  420
ctgaagcag  tgctgtccc  ggcctaccc  ctggactcc  tggagaagc  gatggaaaa  480
gcccacgag  actcggaga  gctgcggga  atcgtactg  ccatggaaa  ggagatcga  540
gagctgaag  cgaagctgc  gagggccga  gagctgatt  aggagatcc  gagacgtcc  600
cggcatgcc  cttccctgc  cggctccac  gagttgctg  ccctgtccc  ggatccatc  660
cccccgctg  agcctctgg  ggagctgag  ggagatggg  gtccagccg  tgaggcctt  720
gctcacaac  gcgatgaca  cgcctccat  tcctccttc  cccttggcg  tggggtcgg  780
agcagctcc  ccctgcccc  aagccgcca  ggcctgagc  ctgaacagg  agagacggc  840
tcgctggtg  ctacgggca  cctggttcc  gagggcatc  acctgcccc  tcctggcta  900
cagctcgtc  cagacactc  gtgggagca  ctgcagaca  agggccgac  gctgcagaa  960
gacctggag  gcgtcagtc  cgagcggga  gagctccaa  agggcctga  acggagcaa  1020
gaggactgt  ccaagcaga  gcaggtgct  ctggcccag  tccagaact  agagcagct  1080
ctgcggacc  tgcaaggga  cgtgagcca  gcccaggag  gggtgcagc  gcagatggc  1140
gagctggtc  ccacccaca  gtgcctgca  catgaggta  agcggttga  tgaggaaaa  1200
caagggctc  gggccgagc  gctgccatc  tcagccccc  agggctcgc  gcaggagca  1260
ggcgaggag  aatcactgc  cagctctgt  ccagagctg  agcagctgc  gtgctgcac  1320
cggcaagag  cgagggccc  gctgcaggc  caggagcac  gggccgagc  cctgcggat  1380
gagatcgtg  cgctgcggg  ggctctgga  gaggagaca  tggccaggg  cagcctgga  1440
gggcagctg  gggtgcagc  ggaggagac  gaggtgctg  aggcctccc  gtgcagcct  1500
aggacagag  tggagcggg  gcagcagga  cagagcaag  cccagctcc  agacctcct  1560
tcagaacag  gggccaagg  gctgcggct  caggcagag  tggagacca  tgagcagtg  1620
agagggatt  cgtgcgact  tcccaggcc  tgcaggtgc  cctagagcg  atccgccag  1680
ctgagaccc  ggagcaagt  cgcagcatc  tggatgagg  gccactcac  gacgtcagg  1740
acatcaagg  cacctgagg  gtcaggata  ccccacccc  accctggga  agacgcctt  1800
ccccactcc  gaaccatga  gcctcgctc  ggggtcttg  atggctttt  caccgtccc  1860
gagactggg  ttgagggga  tgacggggg  caccaccgc  ccgccctcc  gcgcctcct  1920
ccagggtgg  tgggcctcc  gttctcagg  gtcacacct  ggtgagggg  ccaagcccc  1980
cccggaacc  aaggtgcag  ctcaggcct  cggctttct  gctgctgtg  tgcctcctg  2040
gctccagcc  tcccctgcc  ccagcccgt  ccctgccca  ggcacagcg  agccatggg  2100
gctgggagt  cccatcaga  gcagtgagg  gggccccgg  cctgggaca  gcagctgcc  2160
tctggtctg  atgacacta  gacgcttgt  cacagcggc  acccagacc  ccaagcttg  2220
acagaggca  ggccagact  ttccgtcgt  tattttcaa  aaataagca  ctcagcgca  2280
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2309



<210> 8414
<211> 538
<212> PRT
<213> Homo sapiens
<308> NP_079092
<400> 8414

Met Ala Ala Ala Ala Pro Val Ala Ala Asp Asp Asp Glu Arg Arg Arg 
  1               5                  10                  15
Arg Pro Gly Ala Ala Leu Glu Asp Ser Arg Ser Gln Glu Gly Ala Asn 
             20                  25                  30
Gly Glu Ala Glu Ser Gly Glu Leu Ser Arg Leu Arg Ala Glu Leu Ala 
         35                  40                  45
Gly Ala Leu Ala Glu Met Glu Thr Met Lys Ala Val Ala Glu Val Ser 
     50                  55                  60
Glu Ser Thr Lys Ala Glu Ala Val Ala Ala Val Gln Arg Gln Cys Gln 
 65                  70                  75                  80
Glu Glu Val Ala Ser Leu Gln Ala Ile Leu Lys Asp Ser Ile Ser Ser 
                 85                  90                  95
Tyr Glu Ala Gln Ile Thr Ala Leu Lys Gln Glu Arg Gln Gln Gln Gln 
             100                105                110
Gln Asp Cys Glu Glu Lys Glu Arg Glu Leu Gly Arg Leu Lys Gln Leu 
         115                120                125
Leu Ser Arg Ala Tyr Pro Leu Asp Ser Leu Glu Lys Gln Met Glu Lys 
     130                135                140
Ala His Glu Asp Ser Glu Lys Leu Arg Glu Ile Val Leu Pro Met Glu 
 145                150                155                160
Lys Glu Ile Glu Glu Leu Lys Ala Lys Leu Leu Arg Ala Glu Glu Leu 
                 165                170                175
Ile Gln Glu Ile Gln Arg Arg Pro Arg His Ala Pro Ser Leu His Gly 
             180                185                190
Ser Thr Glu Leu Leu Pro Leu Ser Arg Asp Pro Ser Pro Pro Leu Glu 
         195                200                205
Pro Leu Glu Glu Leu Ser Gly Asp Gly Gly Pro Ala Ala Glu Ala Phe 
     210                215                220
Ala His Asn Cys Asp Asp Ser Ala Ser Ile Ser Ser Phe Ser Leu Gly 
 225                230                235                240
Gly Gly Val Gly Ser Ser Ser Ser Leu Pro Gln Ser Arg Gln Gly Leu 
                 245                250                255
Ser Pro Glu Gln Glu Glu Thr Ala Ser Leu Val Ser Thr Gly Thr Leu 
             260                265                270
Val Pro Glu Gly Ile Tyr Leu Pro Pro Pro Gly Tyr Gln Leu Val Pro 
         275                280                285
Asp Thr Gln Trp Glu Gln Leu Gln Thr Glu Gly Arg Gln Leu Gln Lys 
     290                295                300
Asp Leu Glu Ser Val Ser Arg Glu Arg Asp Glu Leu Gln Glu Gly Leu 
 305                310                315                320
Arg Arg Ser Asn Glu Asp Cys Ala Lys Gln Met Gln Val Leu Leu Ala 
                 325                330                335
Gln Val Gln Asn Ser Glu Gln Leu Leu Arg Thr Leu Gln Gly Thr Val 
             340                345                350
Ser Gln Ala Gln Glu Arg Val Gln Leu Gln Met Ala Glu Leu Val Thr 
         355                360                365
Thr His Lys Cys Leu His His Glu Val Lys Arg Leu Asn Glu Glu Asn 
     370                375                380
Gln Gly Leu Arg Ala Glu Gln Leu Pro Ser Ser Ala Pro Gln Gly Ser 
 385                390                395                400
Gln Gln Glu Gln Gly Glu Glu Glu Ser Leu Pro Ser Ser Val Pro Glu 
                 405                410                415
Leu Gln Gln Leu Leu Cys Cys Thr Arg Gln Glu Ala Arg Ala Arg Leu 
             420                425                430
Gln Ala Gln Glu His Gly Ala Glu Arg Leu Arg Ile Glu Ile Val Thr 
         435                440                445
Leu Arg Glu Ala Leu Glu Glu Glu Thr Val Ala Arg Ala Ser Leu Glu 
     450                455                460
Gly Gln Leu Arg Val Gln Arg Glu Glu Thr Glu Val Leu Glu Ala Ser 
 465                470                475                480
Leu Cys Ser Leu Arg Thr Glu Met Glu Arg Val Gln Gln Glu Gln Ser 
                 485                490                495
Lys Ala Gln Leu Pro Asp Leu Leu Ser Glu Gln Arg Ala Lys Val Leu 
             500                505                510
Arg Leu Gln Ala Glu Leu Glu Thr Ser Glu Gln Cys Arg Gly Ile Ser 
         515                520                525
Cys Asp Cys Pro Arg Pro Cys Arg Cys Ala 
     530                535



<210> 8415
<211> 2222
<212> DNA
<213> Rattus norvegicus
<308> U34932
<400> 8415

gcggccgcg  cgacgtgcc  tcaccagtg  gtgcgggaa  ccgccgttt  ggctgagac  60
atggcagct  cgccagcag  cctagcgct  gatccccag  cccaagagg  gcaaaagga  120
gcatccgaa  caagtgagc  cagtaggct  cgtgccgaa  tggccggtg  actggcaga  180
atggaaacc  tgaaggctg  agctgaggt  agcgagagc  ccaaggcag  ggcggtggc  240
gcagtgcag  gacagtgcc  agaggaggt  gcttccctg  aggccatcc  gaaagactc  300
atcagcagc  acgagaccc  gatcgcagc  ctgaaacag  agcggcagc  gcagcaaca  360
gactctgag  agaaggagc  agagctggg  cacctcaaa  agctgctgg  ccgggccca  420
cctttggac  ccttggaga  gcaaatgga  aaggctcac  aagactcag  aaagcttcg  480
gagatcgtg  tgcccatgg  gcaggagat  gcagagctg  aggtgaagc  gctgagggc  540
gaagagctg  tccaagaga  ccagagacg  ccaaggcag  ctgcctccc  gcatggctc  600
acagagttg  ttccactat  aaggaaccc  tcaccacca  tggaaccct  ggaggaacc  660
agtggagac  caggcccag  tgctgaggc  ttcgcccac  actgtgatg  cagtgcctc  720
atctcttcc  tctccctcg  tggggccgc  ggtagtgtc  ccctacgag  tccccaagg  780
ctcagcccc  agcaggaag  gacagcttc  ctggtgtct  ctggcactc  ggtccccga  840
ggcatctac  taccccctc  ggggtacca  cttgttcca  acagccagt  ggagcaact  900
caggtagag  ggcggcagc  gcagaagga  ctggaaagt  tccgccgtg  gcgggatga  960
ctgcaggaa  gactgagcc  gagcaatga  gactgtgcc  agcagatgc  ggtgctcct  1020
gcccaggtc  agaactcag  gcagctgct  cgaactctg  agggaaccg  gagccaggc  1080
caggagcgg  tgcagcggc  gatggcaga  ctggccact  ctcacaagt  cctgagcca  1140
gaggttaaa  gactgaatg  agaaaatcg  ggactccgg  ctgagcagc  gccatcctc  1200
gccctccag  gctcagagc  gcaggagga  caggacgag  ccctgccaa  ctccataca  1260
gagctacac  agctggtgc  gcacacccg  cagcaggct  gggccaggc  gcaggcaca  1320
gagcatgag  ctgagcgcc  gcgcattga  attgtgaag  tgcgggagg  actagacga  1380
gagacagca  ccaaggcca  tctggaggg  cagctgagg  tgcagcgag  agagacaga  1440
gtgctggag  cctccctgt  cagcctgag  atagagaca  agcgggtcc  acaagagca  1500
cacaaggcc  agctcacag  tctcctctc  gaacagaga  ccaaggcac  acggctgca  1560
gctgagctg  agaccagtg  acaggtgca  agggacttc  tacggctat  ccaggccct  1620
caggtgcgc  tggagcaga  ccgccaagc  gacactctg  agcaagtac  tagcattct  1680
gacgaggca  ccctcaggg  cattaagga  attaaggac  cgtgagggg  caggcgaga  1740
gcctccctg  tggggaagc  gccccattc  ctaccagaa  tgtgaggtg  tgactgcag  1800
tctcagaat  gagtccgtc  gctgcaaac  tggacagtg  tgtcccggg  cactacttc  1860
acccagggt  gctggccct  ccctcaggg  tgatacctg  aagagggtc  tagcctcct  1920
ccagaacca  agctttcag  ctgccatgc  ccctcatgg  tccagttct  ccaccccgt  1980
acctcgggc  agcagccag  cccactctc  gcgtaccca  cttatggct  gaagctgtt  2040
gattcagtg  ctcctcaca  agaggccct  ggacacaca  ctgctttct  gactgtatg  2100
cactaaggt  tttgtccat  ggtacccga  ataggcccc  agacataag  aagcaaggc  2160
agacttttc  gtcatttat  ttcaataaa  aagcagtca  ctaaaaaaa  aaaaaaaaa  2220
aa  2222



<210> 8416
<211> 554
<212> PRT
<213> Rattus norvegicus
<308> AAA79137
<400> 8416

Met Ala Ala Ala Pro Ala Ala Leu Ala Leu Asp Pro Gln Pro Gln Glu 
  1               5                  10                  15
Glu Gln Lys Asp Ala Ser Glu Ser Ser Glu Leu Ser Arg Leu Arg Ala 
             20                  25                  30
Glu Leu Ala Gly Ala Leu Ala Glu Met Glu Thr Met Lys Ala Val Ala 
         35                  40                  45
Glu Val Ser Glu Ser Thr Lys Ala Glu Ala Val Ala Ala Val Gln Arg 
     50                  55                  60
Gln Cys Gln Glu Glu Val Ala Ser Leu Gln Ala Ile Leu Lys Asp Ser 
 65                  70                  75                  80
Ile Ser Ser Tyr Glu Thr Gln Ile Ala Ala Leu Lys Gln Glu Arg Gln 
                 85                  90                  95
Gln Gln Gln Gln Asp Ser Glu Glu Lys Glu Arg Glu Leu Gly His Leu 
             100                105                110
Lys Gln Leu Leu Ala Arg Ala His Pro Leu Asp Ser Leu Glu Lys Gln 
         115                120                125
Met Glu Lys Ala His Glu Asp Ser Glu Lys Leu Arg Glu Ile Val Leu 
     130                135                140
Pro Met Glu Gln Glu Ile Ala Glu Leu Lys Val Lys Leu Leu Arg Ala 
 145                150                155                160
Glu Glu Leu Ile Gln Glu Ile Gln Arg Arg Pro Arg Gln Pro Ala Ser 
                 165                170                175
Leu His Gly Ser Thr Glu Leu Leu Pro Leu Ser Arg Asn Pro Ser Pro 
             180                185                190
Pro Leu Glu Pro Ser Glu Glu Pro Ser Gly Asp Ala Gly Pro Ala Ala 
         195                200                205
Glu Ala Phe Ala His Asn Cys Asp Asp Ser Ala Ser Ile Ser Ser Phe 
     210                215                220
Ser Leu Gly Gly Ala Ala Gly Ser Val Ser Leu Arg Gly Pro Gln Gly 
 225                230                235                240
Leu Ser Pro Glu Gln Glu Glu Thr Ala Ser Leu Val Ser Thr Gly Thr 
                 245                250                255
Leu Val Pro Glu Gly Ile Tyr Leu Pro Pro Pro Gly Tyr Gln Leu Val 
             260                265                270
Pro Asp Ser Gln Trp Glu Gln Leu Gln Val Glu Gly Arg Gln Leu Gln 
         275                280                285
Lys Glu Leu Glu Ser Val Arg Arg Glu Arg Asp Glu Leu Gln Glu Gly 
     290                295                300
Leu Ser Arg Ser Asn Glu Asp Cys Ala Lys Gln Met Gln Val Leu Leu 
 305                310                315                320
Ala Gln Val Gln Asn Ser Glu Gln Leu Leu Arg Thr Leu Gln Gly Thr 
                 325                330                335
Val Ser Gln Ala Gln Glu Arg Val Gln Arg Gln Met Ala Glu Leu Ala 
             340                345                350
Thr Ser His Lys Cys Leu Ser Gln Glu Val Lys Arg Leu Asn Glu Glu 
         355                360                365
Asn Arg Gly Leu Arg Ala Glu Gln Leu Pro Ser Ser Ala Leu Gln Gly 
     370                375                380
Ser Glu Gln Gln Glu Asp Gln Asp Glu Ala Leu Pro Ser Ser Ile Gln 
 385                390                395                400
Glu Leu His Gln Leu Val Arg His Thr Arg Gln Gln Ala Arg Ala Arg 
                 405                410                415
Gln Gln Ala Gln Glu His Glu Ala Glu Arg Leu Arg Ile Glu Ile Val 
             420                425                430
Lys Leu Arg Glu Ala Leu Asp Glu Glu Thr Ala Ala Lys Ala Ser Leu 
         435                440                445
Glu Gly Gln Leu Arg Val Gln Arg Glu Glu Thr Asp Val Leu Glu Ala 
     450                455                460
Ser Leu Cys Ser Leu Arg Ile Glu Thr Glu Arg Val Gln Gln Glu His 
 465                470                475                480
His Lys Ala Gln Leu Thr Asp Leu Leu Ser Glu Gln Arg Ala Lys Ala 
                 485                490                495
Leu Arg Leu Gln Ala Glu Leu Glu Thr Ser Glu Gln Val Gln Arg Asp 
             500                505                510
Phe Val Arg Leu Ser Gln Ala Leu Gln Val Arg Leu Glu Gln Ile Arg 
         515                520                525
Gln Ala Asp Thr Leu Glu Gln Val Arg Ser Ile Leu Asp Glu Ala Pro 
     530                535                540
Leu Arg Asp Ile Lys Asp Ile Lys Asp Ser 
 545                550



<210> 8417
<211> 2309
<212> DNA
<213> Homo sapiens
<308> NM_024816
<400> 8417

gcgctccgt  accagggag  gcgggaatc  gccgtttgc  ctgaggcaa  ggcggcagc  60
gcgccggtg  ccgcggacg  cgatgagcg  cggcggcgg  cgggggctg  actggagga  120
tcccggtcc  aggaagggg  aaatggtga  gccgagtca  gtgagctca  ccggcttcg  180
gctgagctg  caggcgccc  ggcagaaat  gaaaccatg  aggctgtgg  agaggtgag  240
gagagcacg  aggccgagg  tgtggctgc  gtgcagcgg  agtgccaag  ggaggtggc  300
tcgctgcag  ccatcctga  agactccat  agcagctat  aagcccaga  caccgccct  360
aagcaggag  gacagcagc  gcagcagga  tgtgaggag  aggagcggg  gctgggccg  420
ctgaagcag  tgctgtccc  ggcctaccc  ctggactcc  tggagaagc  gatggaaaa  480
gcccacgag  actcggaga  gctgcggga  atcgtactg  ccatggaaa  ggagatcga  540
gagctgaag  cgaagctgc  gagggccga  gagctgatt  aggagatcc  gagacgtcc  600
cggcatgcc  cttccctgc  cggctccac  gagttgctg  ccctgtccc  ggatccatc  660
cccccgctg  agcctctgg  ggagctgag  ggagatggg  gtccagccg  tgaggcctt  720
gctcacaac  gcgatgaca  cgcctccat  tcctccttc  cccttggcg  tggggtcgg  780
agcagctcc  ccctgcccc  aagccgcca  ggcctgagc  ctgaacagg  agagacggc  840
tcgctggtg  ctacgggca  cctggttcc  gagggcatc  acctgcccc  tcctggcta  900
cagctcgtc  cagacactc  gtgggagca  ctgcagaca  agggccgac  gctgcagaa  960
gacctggag  gcgtcagtc  cgagcggga  gagctccaa  agggcctga  acggagcaa  1020
gaggactgt  ccaagcaga  gcaggtgct  ctggcccag  tccagaact  agagcagct  1080
ctgcggacc  tgcaaggga  cgtgagcca  gcccaggag  gggtgcagc  gcagatggc  1140
gagctggtc  ccacccaca  gtgcctgca  catgaggta  agcggttga  tgaggaaaa  1200
caagggctc  gggccgagc  gctgccatc  tcagccccc  agggctcgc  gcaggagca  1260
ggcgaggag  aatcactgc  cagctctgt  ccagagctg  agcagctgc  gtgctgcac  1320
cggcaagag  cgagggccc  gctgcaggc  caggagcac  gggccgagc  cctgcggat  1380
gagatcgtg  cgctgcggg  ggctctgga  gaggagaca  tggccaggg  cagcctgga  1440
gggcagctg  gggtgcagc  ggaggagac  gaggtgctg  aggcctccc  gtgcagcct  1500
aggacagag  tggagcggg  gcagcagga  cagagcaag  cccagctcc  agacctcct  1560
tcagaacag  gggccaagg  gctgcggct  caggcagag  tggagacca  tgagcagtg  1620
agagggatt  cgtgcgact  tcccaggcc  tgcaggtgc  cctagagcg  atccgccag  1680
ctgagaccc  ggagcaagt  cgcagcatc  tggatgagg  gccactcac  gacgtcagg  1740
acatcaagg  cacctgagg  gtcaggata  ccccacccc  accctggga  agacgcctt  1800
ccccactcc  gaaccatga  gcctcgctc  ggggtcttg  atggctttt  caccgtccc  1860
gagactggg  ttgagggga  tgacggggg  caccaccgc  ccgccctcc  gcgcctcct  1920
ccagggtgg  tgggcctcc  gttctcagg  gtcacacct  ggtgagggg  ccaagcccc  1980
cccggaacc  aaggtgcag  ctcaggcct  cggctttct  gctgctgtg  tgcctcctg  2040
gctccagcc  tcccctgcc  ccagcccgt  ccctgccca  ggcacagcg  agccatggg  2100
gctgggagt  cccatcaga  gcagtgagg  gggccccgg  cctgggaca  gcagctgcc  2160
tctggtctg  atgacacta  gacgcttgt  cacagcggc  acccagacc  ccaagcttg  2220
acagaggca  ggccagact  ttccgtcgt  tattttcaa  aaataagca  ctcagcgca  2280
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2309



<210> 8418
<211> 538
<212> PRT
<213> Homo sapiens
<308> NP_079092
<400> 8418

Met Ala Ala Ala Ala Pro Val Ala Ala Asp Asp Asp Glu Arg Arg Arg 
  1               5                  10                  15
Arg Pro Gly Ala Ala Leu Glu Asp Ser Arg Ser Gln Glu Gly Ala Asn 
             20                  25                  30
Gly Glu Ala Glu Ser Gly Glu Leu Ser Arg Leu Arg Ala Glu Leu Ala 
         35                  40                  45
Gly Ala Leu Ala Glu Met Glu Thr Met Lys Ala Val Ala Glu Val Ser 
     50                  55                  60
Glu Ser Thr Lys Ala Glu Ala Val Ala Ala Val Gln Arg Gln Cys Gln 
 65                  70                  75                  80
Glu Glu Val Ala Ser Leu Gln Ala Ile Leu Lys Asp Ser Ile Ser Ser 
                 85                  90                  95
Tyr Glu Ala Gln Ile Thr Ala Leu Lys Gln Glu Arg Gln Gln Gln Gln 
             100                105                110
Gln Asp Cys Glu Glu Lys Glu Arg Glu Leu Gly Arg Leu Lys Gln Leu 
         115                120                125
Leu Ser Arg Ala Tyr Pro Leu Asp Ser Leu Glu Lys Gln Met Glu Lys 
     130                135                140
Ala His Glu Asp Ser Glu Lys Leu Arg Glu Ile Val Leu Pro Met Glu 
 145                150                155                160
Lys Glu Ile Glu Glu Leu Lys Ala Lys Leu Leu Arg Ala Glu Glu Leu 
                 165                170                175
Ile Gln Glu Ile Gln Arg Arg Pro Arg His Ala Pro Ser Leu His Gly 
             180                185                190
Ser Thr Glu Leu Leu Pro Leu Ser Arg Asp Pro Ser Pro Pro Leu Glu 
         195                200                205
Pro Leu Glu Glu Leu Ser Gly Asp Gly Gly Pro Ala Ala Glu Ala Phe 
     210                215                220
Ala His Asn Cys Asp Asp Ser Ala Ser Ile Ser Ser Phe Ser Leu Gly 
 225                230                235                240
Gly Gly Val Gly Ser Ser Ser Ser Leu Pro Gln Ser Arg Gln Gly Leu 
                 245                250                255
Ser Pro Glu Gln Glu Glu Thr Ala Ser Leu Val Ser Thr Gly Thr Leu 
             260                265                270
Val Pro Glu Gly Ile Tyr Leu Pro Pro Pro Gly Tyr Gln Leu Val Pro 
         275                280                285
Asp Thr Gln Trp Glu Gln Leu Gln Thr Glu Gly Arg Gln Leu Gln Lys 
     290                295                300
Asp Leu Glu Ser Val Ser Arg Glu Arg Asp Glu Leu Gln Glu Gly Leu 
 305                310                315                320
Arg Arg Ser Asn Glu Asp Cys Ala Lys Gln Met Gln Val Leu Leu Ala 
                 325                330                335
Gln Val Gln Asn Ser Glu Gln Leu Leu Arg Thr Leu Gln Gly Thr Val 
             340                345                350
Ser Gln Ala Gln Glu Arg Val Gln Leu Gln Met Ala Glu Leu Val Thr 
         355                360                365
Thr His Lys Cys Leu His His Glu Val Lys Arg Leu Asn Glu Glu Asn 
     370                375                380
Gln Gly Leu Arg Ala Glu Gln Leu Pro Ser Ser Ala Pro Gln Gly Ser 
 385                390                395                400
Gln Gln Glu Gln Gly Glu Glu Glu Ser Leu Pro Ser Ser Val Pro Glu 
                 405                410                415
Leu Gln Gln Leu Leu Cys Cys Thr Arg Gln Glu Ala Arg Ala Arg Leu 
             420                425                430
Gln Ala Gln Glu His Gly Ala Glu Arg Leu Arg Ile Glu Ile Val Thr 
         435                440                445
Leu Arg Glu Ala Leu Glu Glu Glu Thr Val Ala Arg Ala Ser Leu Glu 
     450                455                460
Gly Gln Leu Arg Val Gln Arg Glu Glu Thr Glu Val Leu Glu Ala Ser 
 465                470                475                480
Leu Cys Ser Leu Arg Thr Glu Met Glu Arg Val Gln Gln Glu Gln Ser 
                 485                490                495
Lys Ala Gln Leu Pro Asp Leu Leu Ser Glu Gln Arg Ala Lys Val Leu 
             500                505                510
Arg Leu Gln Ala Glu Leu Glu Thr Ser Glu Gln Cys Arg Gly Ile Ser 
         515                520                525
Cys Asp Cys Pro Arg Pro Cys Arg Cys Ala 
     530                535



<210> 8419
<211> 726
<212> DNA
<213> Rattus norvegicus
<308> U34963
<400> 8419

gcccatctc  attataaaa  tgtctcaga  caaccggga  ctggtggtt  actttctct  60
ctacaagct  tcccagaaa  gatacagct  gagtcagtt  agcgatgtc  aagagaaca  120
gactgaagc  ccagaagaa  ctgaaccag  aagggagac  cccagtgcc  tcaatggca  180
cccatcctg  cacctggcg  atagccccg  ggtgaatgg  gccactggc  acagcagca  240
tttggatgc  cgggaggta  tccccatgg  agcagtgaa  caagcgctg  gagaggctg  300
cgatgagtt  gaactgcgg  accggagag  attcagtga  ctaacatcc  agcttcata  360
aaccccagg  acagtatat  agagctttg  acaggtagt  aatgaactc  ttcgggatg  420
ggtaaactg  ggtcgcatt  tggcctcct  ctcctttgg  ggggcactg  gcgtggaaa  480
cgtagacaa  gagatgcag  tattggtga  tcggattgc  agttggatg  ccacctacc  540
gaatgacca  ctagagcct  ggatccagg  gaacggcgg  tgggacact  ttgtggatc  600
ctacgggaa  aatacagca  ccgagagcc  gaaaggcca  gagcgtttc  accgctggt  660
cctgacggg  atgactgtg  ctggtgtag  tctgctggg  tcactcttc  gtcggaagt  720
accaga  726



<210> 8420
<211> 233
<212> PRT
<213> Rattus norvegicus
<308> P53563
<400> 8420

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
  1               5                  10                  15
Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
             20                  25                  30
Asn Arg Thr Glu Ala Pro Glu Glu Thr Glu Pro Glu Arg Glu Thr Pro 
         35                  40                  45
Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
     50                  55                  60
Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
 65                  70                  75                  80
Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                 85                  90                  95
Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
             100                105                110
His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
         115                120                125
Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
     130                135                140
Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
 145                150                155                160
Val Leu Val Ser Arg Ile Ala Ser Trp Met Ala Thr Tyr Leu Asn Asp 
                 165                170                175
His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
             180                185                190
Asp Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
         195                200                205
Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
     210                215                220
Leu Leu Gly Ser Leu Phe Ser Arg Lys 
 225                230



<210> 8421
<211> 926
<212> DNA
<213> Homo sapiens
<308> Z23115
<400> 8421

gaatctctt  ctctccctt  agaatctta  cttggcttt  gatcttaga  gagaatcac  60
aaccagaga  gagactcag  gagtgagca  gtgttttgg  caatggact  gttgagccc  120
tccctatta  aaaaatgtc  cagagcaac  gggagctgg  ggttgactt  ctctcctac  180
agctttccc  gaaaggata  agctggagt  agtttagtg  tgtggaaga  aacaggact  240
aggccccag  agggactga  tcggagatg  agaccccca  tgccatcaa  ggcaaccca  300
cctggcacc  ggcagacag  cccgcggtg  atggagcca  tgcgcacag  agcagtttg  360
atgcccggg  ggtgatccc  atggcagca  taaagcaag  gctgaggga  gcaggcgac  420
agtttgaac  gcggtaccg  cgggcattc  gtgacctga  atcccagct  cacatcacc  480
cagggacag  atatcagag  tttgaacag  tagtgaatg  actcttccg  gatggggta  540
actggggtc  cattgtggc  tttttctcc  tcggcgggg  actgtgcgt  gaaagcgta  600
acaaggaga  gcaggtatt  gtgagtcgg  tcgcagctt  gatggccac  tacctgaat  660
accacctag  gccttggat  caggagaac  gcggctggg  tacttttgt  gaactctat  720
ggaacaatg  agcagccga  agccgaaag  gccaggaac  cttcaaccg  tggttcctg  780
cgggcatga  tgtggccgg  gtggttctg  tgggctcac  cttcagtcg  aaatgacca  840
acactgacc  tccactcta  cctcccacc  ccttctctg  tccaccaca  cctccgtcc  900
gccgccatt  ccaccagga  aacccg  926



<210> 8422
<211> 233
<212> PRT
<213> Homo sapiens
<308> Q07817
<400> 8422

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
  1               5                  10                  15
Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
             20                  25                  30
Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
         35                  40                  45
Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
     50                  55                  60
Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
 65                  70                  75                  80
Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                 85                  90                  95
Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
             100                105                110
His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
         115                120                125
Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
     130                135                140
Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
 145                150                155                160
Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                 165                170                175
His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
             180                185                190
Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
         195                200                205
Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
     210                215                220
Leu Leu Gly Ser Leu Phe Ser Arg Lys 
 225                230



<210> 8424
<211> 134
<212> PRT
<213> Rattus norvegicus
<308> Q13329
<400> 8424

Met Asp Phe Val Met Lys Gln Ala Leu Gly Gly Ala Thr Lys Asp Met 
  1               5                  10                  15
Gly Lys Met Leu Gly Gly Glu Glu Glu Lys Asp Pro Asp Ala Gln Lys 
             20                  25                  30
Lys Glu Glu Glu Arg Gln Glu Ala Leu Arg Gln Gln Glu Glu Glu Arg 
         35                  40                  45
Lys Ala Lys His Ala Arg Met Glu Ala Glu Arg Glu Lys Val Arg Gln 
     50                  55                  60
Gln Ile Arg Asp Lys Tyr Gly Leu Lys Lys Lys Glu Glu Lys Glu Ala 
 65                  70                  75                  80
Glu Glu Lys Ala Ala Leu Glu Gln Pro Cys Glu Gly Ser Leu Thr Arg 
                 85                  90                  95
Pro Lys Lys Ala Ile Pro Ala Gly Cys Gly Asp Glu Glu Glu Glu Glu 
             100                105                110
Glu Glu Ser Ile Leu Asp Thr Val Leu Lys Tyr Leu Pro Gly Pro Leu 
         115                120                125
Gln Asp Met Phe Lys Lys 
     130



<210> 8425
<211> 1024
<212> DNA
<213> Homo sapiens
<308> AK057826
<400> 8425

agaagccgc  gctccagct  gcctggcgg  attgcacgc  gcggcggga  ctggaatag  960
agaaggaac  acctcgtgg  gtcgggccg  agccctgca  tggctcaga  ggttgcagg  1020
accg  1024



<210> 8426
<211> 134
<212> PRT
<213> Homo sapiens
<308> AAC50229
<400> 8426

Met Asp Phe Val Met Lys Gln Ala Leu Gly Gly Ala Thr Lys Asp Met 
  1               5                  10                  15
Gly Lys Met Leu Gly Gly Glu Glu Glu Lys Asp Pro Asp Ala Gln Lys 
             20                  25                  30
Lys Glu Glu Glu Arg Gln Glu Ala Leu Arg Gln Gln Glu Glu Glu Arg 
         35                  40                  45
Lys Ala Lys His Ala Arg Met Glu Ala Glu Arg Glu Lys Val Arg Gln 
     50                  55                  60
Gln Ile Arg Asp Lys Tyr Gly Leu Lys Lys Lys Glu Glu Lys Glu Ala 
 65                  70                  75                  80
Glu Glu Lys Ala Ala Leu Glu Gln Pro Cys Glu Gly Ser Leu Thr Arg 
                 85                  90                  95
Pro Lys Lys Ala Ile Pro Ala Gly Cys Gly Asp Glu Glu Glu Glu Glu 
             100                105                110
Glu Glu Ser Ile Leu Asp Thr Val Leu Lys Tyr Leu Pro Gly Pro Leu 
         115                120                125
Gln Asp Met Phe Lys Lys 
     130



<210> 8427
<211> 3269
<212> DNA
<213> Rattus norvegicus
<308> U35244
<400> 8427

ggacaggat  gacagattg  tagctcttt  tcgattccg  gggtggtgg  gcatggccg  60
tcttagatg  cggctcacc  gtcatacgg  cgagtgaac  tgaacgtgc  gcgcgaggc  120
gtgcgtcgg  agctgcgcg  gtttctgga  aagtgcgct  ggagcaagg  aatagtgtg  180
gatgaatac  taacaggac  gtttggact  attgcacag  actcactac  aaaggaaca  240
gaagtggaa  aaatgttca  cctcaaagg  agtcgtttg  cagcggctg  tgtcaagaa  300
atcattttt  tggtcagac  caggctaga  ttaatggat  tgattgccg  gaacgtact  360
agtgaggac  ggcgtggcc  taccaggga  ttccatatt  tatttgtgc  tcgtcggag  420
ctactgtgt  agcaaaggc  gaaggacct  ggtgtgttg  gatccttta  ttatcgaga  480
gagtacagt  tagatctca  tccatttga  ggggacctc  tatccatgg  gtcagagag  540
gctttcaaa  aatgctacc  tgaaggcga  cagacaagc  tgtaccacg  agccaaggg  600
ctgatgacc  tgcaggcgc  gtatggaac  atcccccag  tctttggga  aggagagtg  660
gctcggcaa  tggccaata  gatggtcag  atgaaaagg  agtttacag  cagccaaaa  720
tcagtgttc  ccgtgtttg  taacctctt  ctgcttgat  gcaacgtgg  tctgctgac  780
ccgctcgcc  cccagctca  gtacgaagg  ctcatcgac  agatttacg  cattcagaa  840
agttatgtg  agttacctc  agagaaatt  gcacccaag  agcagggcg  tggtggcgg  900
aaggacctt  ccacagagg  aaagaagct  cagctcaac  ccgcagagg  actctatgc  960
gagatccga  acaagaact  caacgctgt  ggctccgtg  tcagcaaga  ggcgaagat  1020
atctccgcg  cctttgagg  gcgacacaa  gctaagacg  ttggagaga  caagcaatt  1080
gtctcccag  ttccccaca  gcaggcggc  agggggtcg  ttgccaacc  cacctcaat  1140
gcagagtta  tcaaagacg  caccacttc  gaagacttc  ttgataagt  gacggtgga  1200
caggagttc  tgtccggga  agacaccga  aaggtcaac  attacatcg  ggactgcat  1260
gcccaaaag  acccgctca  caaggtcct  agattggtt  gcctccagt  tatgtgcaa  1320
agtgggctc  agcagaagg  tctggacta  tacaaaagg  aaattctcc  gacctacgg  1380
tatgagcac  tactgaccc  gaacaacct  gagaaggcc  gcctgctaa  ggctcagac  1440
gggggcaga  acaactacc  aacgattcg  aaaacatta  gcctctgga  ggacgatgt  1500
aatgaacaa  accccacag  catatccta  gtgtacagt  gttacgcac  actcagcgt  1560
cgactcgcc  agctccttt  tcggccagg  tggaggagc  tcgaggagg  tctccgcat  1620
ctcccaggg  cccactttg  agaaaggca  ccactgccc  ccggcgtgc  gaagaaacg  1680
cagccagga  aaaacagag  cacactggt  tttttcctc  ggggcgtca  ctttgctga  1740
atcgcagcc  tgcgttttc  ctcccagct  gaagacgga  gcacagagt  tgtaattgc  1800
accactaaa  tgataaatg  aagcagctg  ctagaagct  tcatggaaa  gcctttcta  1860
gctgtcaga  gggacagtg  gctgcccct  agaacgtgt  gcccaaagg  cataaagcc  1920
ggagcatgg  ggcaacggg  ttgtgttcc  tcctgctcc  ctctgtgct  ctaaaccct  1980
aagaaggga  ggtcggcct  ggtaaggac  caatgagct  ggcgtggcg  ctcatgcct  2040
gaactcctc  acttaagag  cacaggcag  aggatcgct  caagtttgg  acagctggg  2100
ctacatagc  agttccagg  aaaagccct  ccttccaga  ataaaggag  tcctgtttc  2160
gaattttta  gcttaaagt  ttcattttc  ggaatagac  gtggggatg  tagccccag  2220
agccacgca  ctgtgcacg  gcattaaaa  ggagagcta  ggggataaa  aagaaaata  2280
aagcggaat  ctgaccact  actcacggt  gcattttct  gaccaccta  cccaggaga  2340
tggttttgg  ttgaatacg  agccagcat  gtccatcgc  tgcttctcc  cgcagagca  2400
atttgtgtc  ccagtctcg  ctgatgtga  tcctcaggc  agctttgtt  cctcctgag  2460
atctgagaa  cttgaagga  cttcttgac  tgatgacgt  tctgctgtc  gcgttgact  2520
cgtctgtgc  gttctctga  aaagagtga  ctaagcgcc  ggcagcctc  gccagctaa  2580
cttcggagg  acttctggg  gtgcacgtt  ttaactcaa  actctctgg  gtaggccgc  2640
ccctgatgg  acttctgtc  tacctccgt  tcctctgtg  ttggttctt  tgctccttc  2700
agttcatgc  gctgtctca  tggaaactg  cacatgcac  tctctagcc  tctgactgt  2760
ctcatcttc  cactcccct  tacctggtc  gtctggtga  cgagtgcac  cggtcagtg  2820
cagtcacac  gtgacagtg  ctgtgctgc  gggagcagg  gcaggcatg  tgctgccag  2880
gtctgcctc  tgatcattt  cacatctga  ggagttaag  gcgccaagt  gcagaccaa  2940
ttgatggtt  tctgtcatc  cccaagtct  cagaaaagc  agctgattc  gccggtctg  3000
tcctggccc  ggtgaagtt  ctgtggtta  tagtttccc  atataaagt  gtggtgtct  3060
cattatgcc  tgtgatgta  gtcccctta  tactcaaag  tgcctttgt  tcttaagag  3120
atgctctga  aaagactgt  ggaacggaa  gcttattct  agacagggt  gattgttta  3180
gacatgtct  gacttgttc  gagtttgag  actattctg  tacactggc  gtcccaatt  3240
aagatccta  tttctgtct  aaaaaaaaa  3269



<210> 8428
<211> 597
<212> PRT
<213> Rattus norvegicus
<308> AAC52985
<400> 8428

Met Ala Ala His Leu Ser Tyr Gly Arg Val Asn Leu Asn Val Leu Arg 
  1               5                  10                  15
Glu Ala Val Arg Arg Glu Leu Arg Glu Phe Leu Asp Lys Cys Ala Gly 
             20                  25                  30
Ser Lys Ala Ile Val Trp Asp Glu Tyr Leu Thr Gly Pro Phe Gly Leu 
         35                  40                  45
Ile Ala Gln Tyr Ser Leu Leu Lys Glu His Glu Val Glu Lys Met Phe 
     50                  55                  60
Thr Leu Lys Gly Ser Arg Leu Pro Ala Ala Asp Val Lys Asn Ile Ile 
 65                  70                  75                  80
Phe Leu Val Arg Pro Arg Leu Glu Leu Met Asp Met Ile Ala Glu Asn 
                 85                  90                  95
Val Leu Ser Glu Asp Arg Arg Gly Pro Thr Arg Asp Phe His Ile Leu 
             100                105                110
Phe Val Pro Arg Arg Ser Leu Leu Cys Glu Gln Arg Leu Lys Asp Leu 
         115                120                125
Gly Val Leu Gly Ser Phe Ile Tyr Arg Glu Glu Tyr Ser Leu Asp Leu 
     130                135                140
Ile Pro Phe Asp Gly Asp Leu Leu Ser Met Glu Ser Glu Ser Ala Phe 
 145                150                155                160
Lys Glu Cys Tyr Leu Glu Gly Asp Gln Thr Ser Leu Tyr His Ala Ala 
                 165                170                175
Lys Gly Leu Met Thr Leu Gln Ala Leu Tyr Gly Thr Ile Pro Gln Ile 
             180                185                190
Phe Gly Lys Gly Glu Cys Ala Arg Gln Val Ala Asn Met Met Val Arg 
         195                200                205
Met Lys Arg Glu Phe Thr Gly Ser Gln Asn Ser Val Phe Pro Val Phe 
     210                215                220
Asp Asn Leu Leu Leu Leu Asp Arg Asn Val Asp Leu Leu Thr Pro Leu 
 225                230                235                240
Ala Ser Gln Leu Thr Tyr Glu Gly Leu Ile Asp Glu Ile Tyr Gly Ile 
                 245                250                255
Gln Asn Ser Tyr Val Lys Leu Pro Pro Glu Lys Phe Ala Pro Lys Lys 
             260                265                270
Gln Gly Gly Gly Gly Gly Lys Asp Leu Pro Thr Glu Ala Lys Lys Leu 
         275                280                285
Gln Leu Asn Ser Ala Glu Glu Leu Tyr Ala Glu Ile Arg Asp Lys Asn 
     290                295                300
Phe Asn Ala Val Gly Ser Val Leu Ser Lys Lys Ala Lys Ile Ile Ser 
 305                310                315                320
Ala Ala Phe Glu Glu Arg His Asn Ala Lys Thr Val Gly Glu Ile Lys 
                 325                330                335
Gln Phe Val Ser Gln Leu Pro His Met Gln Ala Ala Arg Gly Ser Leu 
             340                345                350
Ala Asn His Thr Ser Ile Ala Glu Leu Ile Lys Asp Val Thr Thr Ser 
         355                360                365
Glu Asp Phe Phe Asp Lys Leu Thr Val Glu Gln Glu Phe Met Ser Gly 
     370                375                380
Ile Asp Thr Asp Lys Val Asn Asn Tyr Ile Glu Asp Cys Ile Ala Gln 
 385                390                395                400
Lys His Pro Leu Ile Lys Val Leu Arg Leu Val Cys Leu Gln Ser Met 
                 405                410                415
Cys Asn Ser Gly Leu Lys Gln Lys Val Leu Asp Tyr Tyr Lys Arg Glu 
             420                425                430
Ile Leu Gln Thr Tyr Gly Tyr Glu His Ile Leu Thr Leu Asn Asn Leu 
         435                440                445
Glu Lys Ala Gly Leu Leu Lys Ala Gln Thr Gly Gly Arg Asn Asn Tyr 
     450                455                460
Pro Thr Ile Arg Lys Thr Leu Arg Leu Trp Met Asp Asp Val Asn Glu 
 465                470                475                480
Gln Asn Pro Thr Asp Ile Ser Tyr Val Tyr Ser Gly Tyr Ala Pro Leu 
                 485                490                495
Ser Val Arg Leu Ala Gln Leu Leu Ser Arg Pro Gly Trp Arg Ser Ile 
             500                505                510
Glu Glu Val Leu Arg Ile Leu Pro Gly Pro His Phe Glu Glu Arg Gln 
         515                520                525
Pro Leu Pro Thr Gly Val Gln Lys Lys Arg Gln Pro Gly Glu Asn Arg 
     530                535                540
Val Thr Leu Val Phe Phe Leu Gly Gly Val Thr Phe Ala Glu Ile Ala 
 545                550                555                560
Ala Leu Arg Phe Leu Ser Gln Leu Glu Asp Gly Gly Thr Glu Tyr Val 
                 565                570                575
Ile Ala Thr Thr Lys Leu Ile Asn Gly Ser Ser Trp Leu Glu Ala Leu 
             580                585                590
Met Glu Lys Pro Phe 
         595



<210> 8429
<211> 2536
<212> DNA
<213> Homo sapiens
<308> NM_022916
<400> 8429

ggcaggggg  ggtggagca  gatggcggc  catctgtcc  acggccgag  gaacctaaa  60
gtgttgcgc  aggcggtgc  tcgcgagct  cgcgagttc  tggacaagt  cgcaggaag  120
aaggcaata  tttgggatg  atacctaac  ggacccttt  gcctgattg  acagtattc  180
ctattgaag  aacatgaag  ggaaaaaat  ttcacactt  aaggaaatc  tttgccggc  240
gctgatgtg  agaatataa  tttttttgt  agacccagg  tagagttga  ggatataat  300
gctgaaaac  tgctcagtg  agatagacg  ggcccaacg  gagattttc  tattctgtt  360
gtgccacgc  gtagcctgt  gtgcgaaca  cggttgaag  atctgggtg  cttgggatc  420
tttattcac  gggaggagt  cagcttaga  ctcattcca  tcgatgggg  tctcttatc  480
atggaatca  agggtgcat  caaagagtg  tacctggag  gtgaccaga  gagcctgta  540
cacgcagcc  aggggctga  gaccctgca  gctctgtat  gaacgatcc  ccagatctt  600
gggaaagga  aatgcgctc  gcaagtggc  aatatgatg  tcaggatga  gagagagtt  660
acaggaagc  agaattcaa  atttcctgt  tttgataat  tcttgttgc  tgatcggaa  720
gtggattta  taacacctc  tgccactca  ctgacatat  aaggactca  tgatgaaat  780
tatggcatt  agaacagtt  tgtgaaatt  cctccagag  aatttgcac  taagaaaca  840
ggcgatggt  gtaaggacc  ccccacgga  gcaaagaag  tgcagctga  ttctgcaga  900
gagctctat  ctgagatcc  agataagaa  ttcaacgca  ttggctctg  gctcagcaa  960
aaagcaaag  tcatctctg  agcattcga  gaaagacac  atgctaaga  cgtggggga  1020
atcaagcag  ttgtttccc  gttgcccca  atgcaggca  caaggggct  gcttgcaaa  1080
catacctca  ttgcagaat  gatcaaaga  gtcactact  ctgaagact  ttttgataa  1140
ttaaccgtg  aacaggagt  tatgtctgg  atagacact  ataaggtca  caattacat  1200
gaggattgt  tcgcccaaa  gcactcgtt  atcaaggtg  taagactag  ttgcctcca  1260
tccgtgtgt  atagtgggc  caaacaaaa  gttttggat  attacaaaa  agagattct  1320
cagacatac  gctatgagc  catattgac  ttacacaac  tggagaagg  cggcctgct  1380
aaaccgcag  cggggggca  aaacaatta  ccaactata  ggaaaacat  acgcctctg  1440
atggatgat  ttaatgagc  aaaccccac  gacatatcg  atgtgtaca  tgggtatgc  1500
ccgctcagt  tgcggctgg  ccagctgct  tcccggcct  gctggcgga  catcgagga  1560
gtcctccgc  tcctcccag  gccccactt  gaggagcgg  agccactgc  cacaggact  1620
cagaagaaa  gtcaaccgg  agaaaaccg  gtgactctg  tatttttcc  tgggggcgt  1680
accttcgct  aaattgctg  cctgcgatt  ctctcccag  tggaagatg  aggtacaga  1740
tatgtcatt  ccaccacta  actaatgaa  ggaaccagt  ggatagagg  tctgatgga  1800
aaacctttc  aggatgttc  gaggagact  aacaagtgt  ctgcagaat  aactacctc  1860
ttgaagaaa  tgctgaaag  aagtaaaac  ccatagaag  aacatggga  tacagaata  1920
attctgggg  cagcttctt  aattatact  ctgtttact  ctttctccg  ctcttttgt  1980
ttccctttt  ttttttcct  tgagacgga  tcttgctct  tcacccaga  tagagtgca  2040
tggcacggt  tcacctcac  gcaacctcc  cctcctagg  tcaagcaat  ctcctgcct  2100
agcctcctg  gtagctggg  ctacaggca  gcaccacca  acccggcta  tttttgtat  2160
tttagtagc  atggtgttt  accatgttg  ccaggctgg  ctcaaactc  tgacctcag  2220
tgatccacc  gcctcggcc  cccacagtg  tgggattac  ggcctgagc  accgtgcct  2280
gcccctaat  tgctgaaga  agaagaata  aagaaaatc  acctgagta  aagcagcac  2340
ggttttgag  tttctaagc  cagggtctt  attagagac  tctggaaat  cattaagga  2400
ggtgggggt  gataatcca  tcagccaga  aaacggggc  agctcttaa  ataagaaag  2460
tgagactga  gaggtgaaa  tgaaaataa  aagagaaag  tcatcctct  aaaaaaaaa  2520
aaaaaaaaa  aaaaaa  2536



<210> 8430
<211> 596
<212> PRT
<213> Homo sapiens
<308> NP_075067
<400> 8430

Met Ala Ala His Leu Ser Tyr Gly Arg Val Asn Leu Asn Val Leu Arg 
  1               5                  10                  15
Glu Ala Val Arg Arg Glu Leu Arg Glu Phe Leu Asp Lys Cys Ala Gly 
             20                  25                  30
Ser Lys Ala Ile Val Trp Asp Glu Tyr Leu Thr Gly Pro Phe Gly Leu 
         35                  40                  45
Ile Ala Gln Tyr Ser Leu Leu Lys Glu His Glu Val Glu Lys Met Phe 
     50                  55                  60
Thr Leu Lys Gly Asn Arg Leu Pro Ala Ala Asp Val Lys Asn Ile Ile 
 65                  70                  75                  80
Phe Phe Val Arg Pro Arg Leu Glu Leu Met Asp Ile Ile Ala Glu Asn 
                 85                  90                  95
Val Leu Ser Glu Asp Arg Arg Gly Pro Thr Arg Asp Phe His Ile Leu 
             100                105                110
Phe Val Pro Arg Arg Ser Leu Leu Cys Glu Gln Arg Leu Lys Asp Leu 
         115                120                125
Gly Val Leu Gly Ser Phe Ile His Arg Glu Glu Tyr Ser Leu Asp Leu 
     130                135                140
Ile Pro Phe Asp Gly Asp Leu Leu Ser Met Glu Ser Glu Gly Ala Phe 
 145                150                155                160
Lys Glu Cys Tyr Leu Glu Gly Asp Gln Thr Ser Leu Tyr His Ala Ala 
                 165                170                175
Lys Gly Leu Met Thr Leu Gln Ala Leu Tyr Gly Thr Ile Pro Gln Ile 
             180                185                190
Phe Gly Lys Gly Glu Cys Ala Arg Gln Val Ala Asn Met Met Ile Arg 
         195                200                205
Met Lys Arg Glu Phe Thr Gly Ser Gln Asn Ser Ile Phe Pro Val Phe 
     210                215                220
Asp Asn Leu Leu Leu Leu Asp Arg Asn Val Asp Leu Leu Thr Pro Leu 
 225                230                235                240
Ala Thr Gln Leu Thr Tyr Glu Gly Leu Ile Asp Glu Ile Tyr Gly Ile 
                 245                250                255
Gln Asn Ser Tyr Val Lys Leu Pro Pro Glu Lys Phe Ala Pro Lys Lys 
             260                265                270
Gln Gly Asp Gly Gly Lys Asp Leu Pro Thr Glu Ala Lys Lys Leu Gln 
         275                280                285
Leu Asn Ser Ala Glu Glu Leu Tyr Ala Glu Ile Arg Asp Lys Asn Phe 
     290                295                300
Asn Ala Val Gly Ser Val Leu Ser Lys Lys Ala Lys Ile Ile Ser Ala 
 305                310                315                320
Ala Phe Glu Glu Arg His Asn Ala Lys Thr Val Gly Glu Ile Lys Gln 
                 325                330                335
Phe Val Ser Gln Leu Pro His Met Gln Ala Ala Arg Gly Ser Leu Ala 
             340                345                350
Asn His Thr Ser Ile Ala Glu Leu Ile Lys Asp Val Thr Thr Ser Glu 
         355                360                365
Asp Phe Phe Asp Lys Leu Thr Val Glu Gln Glu Phe Met Ser Gly Ile 
     370                375                380
Asp Thr Asp Lys Val Asn Asn Tyr Ile Glu Asp Cys Ile Ala Gln Lys 
 385                390                395                400
His Ser Leu Ile Lys Val Leu Arg Leu Val Cys Leu Gln Ser Val Cys 
                 405                410                415
Asn Ser Gly Leu Lys Gln Lys Val Leu Asp Tyr Tyr Lys Arg Glu Ile 
             420                425                430
Leu Gln Thr Tyr Gly Tyr Glu His Ile Leu Thr Leu His Asn Leu Glu 
         435                440                445
Lys Ala Gly Leu Leu Lys Pro Gln Thr Gly Gly Arg Asn Asn Tyr Pro 
     450                455                460
Thr Ile Arg Lys Thr Leu Arg Leu Trp Met Asp Asp Val Asn Glu Gln 
 465                470                475                480
Asn Pro Thr Asp Ile Ser Tyr Val Tyr Ser Gly Tyr Ala Pro Leu Ser 
                 485                490                495
Val Arg Leu Ala Gln Leu Leu Ser Arg Pro Gly Trp Arg Ser Ile Glu 
             500                505                510
Glu Val Leu Arg Ile Leu Pro Gly Pro His Phe Glu Glu Arg Gln Pro 
         515                520                525
Leu Pro Thr Gly Leu Gln Lys Lys Arg Gln Pro Gly Glu Asn Arg Val 
     530                535                540
Thr Leu Ile Phe Phe Leu Gly Gly Val Thr Phe Ala Glu Ile Ala Ala 
 545                550                555                560
Leu Arg Phe Leu Ser Gln Leu Glu Asp Gly Gly Thr Glu Tyr Val Ile 
                 565                570                575
Ala Thr Thr Lys Leu Met Asn Gly Thr Ser Trp Ile Glu Ala Leu Met 
             580                585                590
Glu Lys Pro Phe 
         595



<210> 8431
<211> 3269
<212> DNA
<213> Rattus norvegicus
<308> U35244
<400> 8431

ggacaggat  gacagattg  tagctcttt  tcgattccg  gggtggtgg  gcatggccg  60
tcttagatg  cggctcacc  gtcatacgg  cgagtgaac  tgaacgtgc  gcgcgaggc  120
gtgcgtcgg  agctgcgcg  gtttctgga  aagtgcgct  ggagcaagg  aatagtgtg  180
gatgaatac  taacaggac  gtttggact  attgcacag  actcactac  aaaggaaca  240
gaagtggaa  aaatgttca  cctcaaagg  agtcgtttg  cagcggctg  tgtcaagaa  300
atcattttt  tggtcagac  caggctaga  ttaatggat  tgattgccg  gaacgtact  360
agtgaggac  ggcgtggcc  taccaggga  ttccatatt  tatttgtgc  tcgtcggag  420
ctactgtgt  agcaaaggc  gaaggacct  ggtgtgttg  gatccttta  ttatcgaga  480
gagtacagt  tagatctca  tccatttga  ggggacctc  tatccatgg  gtcagagag  540
gctttcaaa  aatgctacc  tgaaggcga  cagacaagc  tgtaccacg  agccaaggg  600
ctgatgacc  tgcaggcgc  gtatggaac  atcccccag  tctttggga  aggagagtg  660
gctcggcaa  tggccaata  gatggtcag  atgaaaagg  agtttacag  cagccaaaa  720
tcagtgttc  ccgtgtttg  taacctctt  ctgcttgat  gcaacgtgg  tctgctgac  780
ccgctcgcc  cccagctca  gtacgaagg  ctcatcgac  agatttacg  cattcagaa  840
agttatgtg  agttacctc  agagaaatt  gcacccaag  agcagggcg  tggtggcgg  900
aaggacctt  ccacagagg  aaagaagct  cagctcaac  ccgcagagg  actctatgc  960
gagatccga  acaagaact  caacgctgt  ggctccgtg  tcagcaaga  ggcgaagat  1020
atctccgcg  cctttgagg  gcgacacaa  gctaagacg  ttggagaga  caagcaatt  1080
gtctcccag  ttccccaca  gcaggcggc  agggggtcg  ttgccaacc  cacctcaat  1140
gcagagtta  tcaaagacg  caccacttc  gaagacttc  ttgataagt  gacggtgga  1200
caggagttc  tgtccggga  agacaccga  aaggtcaac  attacatcg  ggactgcat  1260
gcccaaaag  acccgctca  caaggtcct  agattggtt  gcctccagt  tatgtgcaa  1320
agtgggctc  agcagaagg  tctggacta  tacaaaagg  aaattctcc  gacctacgg  1380
tatgagcac  tactgaccc  gaacaacct  gagaaggcc  gcctgctaa  ggctcagac  1440
gggggcaga  acaactacc  aacgattcg  aaaacatta  gcctctgga  ggacgatgt  1500
aatgaacaa  accccacag  catatccta  gtgtacagt  gttacgcac  actcagcgt  1560
cgactcgcc  agctccttt  tcggccagg  tggaggagc  tcgaggagg  tctccgcat  1620
ctcccaggg  cccactttg  agaaaggca  ccactgccc  ccggcgtgc  gaagaaacg  1680
cagccagga  aaaacagag  cacactggt  tttttcctc  ggggcgtca  ctttgctga  1740
atcgcagcc  tgcgttttc  ctcccagct  gaagacgga  gcacagagt  tgtaattgc  1800
accactaaa  tgataaatg  aagcagctg  ctagaagct  tcatggaaa  gcctttcta  1860
gctgtcaga  gggacagtg  gctgcccct  agaacgtgt  gcccaaagg  cataaagcc  1920
ggagcatgg  ggcaacggg  ttgtgttcc  tcctgctcc  ctctgtgct  ctaaaccct  1980
aagaaggga  ggtcggcct  ggtaaggac  caatgagct  ggcgtggcg  ctcatgcct  2040
gaactcctc  acttaagag  cacaggcag  aggatcgct  caagtttgg  acagctggg  2100
ctacatagc  agttccagg  aaaagccct  ccttccaga  ataaaggag  tcctgtttc  2160
gaattttta  gcttaaagt  ttcattttc  ggaatagac  gtggggatg  tagccccag  2220
agccacgca  ctgtgcacg  gcattaaaa  ggagagcta  ggggataaa  aagaaaata  2280
aagcggaat  ctgaccact  actcacggt  gcattttct  gaccaccta  cccaggaga  2340
tggttttgg  ttgaatacg  agccagcat  gtccatcgc  tgcttctcc  cgcagagca  2400
atttgtgtc  ccagtctcg  ctgatgtga  tcctcaggc  agctttgtt  cctcctgag  2460
atctgagaa  cttgaagga  cttcttgac  tgatgacgt  tctgctgtc  gcgttgact  2520
cgtctgtgc  gttctctga  aaagagtga  ctaagcgcc  ggcagcctc  gccagctaa  2580
cttcggagg  acttctggg  gtgcacgtt  ttaactcaa  actctctgg  gtaggccgc  2640
ccctgatgg  acttctgtc  tacctccgt  tcctctgtg  ttggttctt  tgctccttc  2700
agttcatgc  gctgtctca  tggaaactg  cacatgcac  tctctagcc  tctgactgt  2760
ctcatcttc  cactcccct  tacctggtc  gtctggtga  cgagtgcac  cggtcagtg  2820
cagtcacac  gtgacagtg  ctgtgctgc  gggagcagg  gcaggcatg  tgctgccag  2880
gtctgcctc  tgatcattt  cacatctga  ggagttaag  gcgccaagt  gcagaccaa  2940
ttgatggtt  tctgtcatc  cccaagtct  cagaaaagc  agctgattc  gccggtctg  3000
tcctggccc  ggtgaagtt  ctgtggtta  tagtttccc  atataaagt  gtggtgtct  3060
cattatgcc  tgtgatgta  gtcccctta  tactcaaag  tgcctttgt  tcttaagag  3120
atgctctga  aaagactgt  ggaacggaa  gcttattct  agacagggt  gattgttta  3180
gacatgtct  gacttgttc  gagtttgag  actattctg  tacactggc  gtcccaatt  3240
aagatccta  tttctgtct  aaaaaaaaa  3269



<210> 8432
<211> 597
<212> PRT
<213> Rattus norvegicus
<308> AAC52985
<400> 8432

Met Ala Ala His Leu Ser Tyr Gly Arg Val Asn Leu Asn Val Leu Arg 
  1               5                  10                  15
Glu Ala Val Arg Arg Glu Leu Arg Glu Phe Leu Asp Lys Cys Ala Gly 
             20                  25                  30
Ser Lys Ala Ile Val Trp Asp Glu Tyr Leu Thr Gly Pro Phe Gly Leu 
         35                  40                  45
Ile Ala Gln Tyr Ser Leu Leu Lys Glu His Glu Val Glu Lys Met Phe 
     50                  55                  60
Thr Leu Lys Gly Ser Arg Leu Pro Ala Ala Asp Val Lys Asn Ile Ile 
 65                  70                  75                  80
Phe Leu Val Arg Pro Arg Leu Glu Leu Met Asp Met Ile Ala Glu Asn 
                 85                  90                  95
Val Leu Ser Glu Asp Arg Arg Gly Pro Thr Arg Asp Phe His Ile Leu 
             100                105                110
Phe Val Pro Arg Arg Ser Leu Leu Cys Glu Gln Arg Leu Lys Asp Leu 
         115                120                125
Gly Val Leu Gly Ser Phe Ile Tyr Arg Glu Glu Tyr Ser Leu Asp Leu 
     130                135                140
Ile Pro Phe Asp Gly Asp Leu Leu Ser Met Glu Ser Glu Ser Ala Phe 
 145                150                155                160
Lys Glu Cys Tyr Leu Glu Gly Asp Gln Thr Ser Leu Tyr His Ala Ala 
                 165                170                175
Lys Gly Leu Met Thr Leu Gln Ala Leu Tyr Gly Thr Ile Pro Gln Ile 
             180                185                190
Phe Gly Lys Gly Glu Cys Ala Arg Gln Val Ala Asn Met Met Val Arg 
         195                200                205
Met Lys Arg Glu Phe Thr Gly Ser Gln Asn Ser Val Phe Pro Val Phe 
     210                215                220
Asp Asn Leu Leu Leu Leu Asp Arg Asn Val Asp Leu Leu Thr Pro Leu 
 225                230                235                240
Ala Ser Gln Leu Thr Tyr Glu Gly Leu Ile Asp Glu Ile Tyr Gly Ile 
                 245                250                255
Gln Asn Ser Tyr Val Lys Leu Pro Pro Glu Lys Phe Ala Pro Lys Lys 
             260                265                270
Gln Gly Gly Gly Gly Gly Lys Asp Leu Pro Thr Glu Ala Lys Lys Leu 
         275                280                285
Gln Leu Asn Ser Ala Glu Glu Leu Tyr Ala Glu Ile Arg Asp Lys Asn 
     290                295                300
Phe Asn Ala Val Gly Ser Val Leu Ser Lys Lys Ala Lys Ile Ile Ser 
 305                310                315                320
Ala Ala Phe Glu Glu Arg His Asn Ala Lys Thr Val Gly Glu Ile Lys 
                 325                330                335
Gln Phe Val Ser Gln Leu Pro His Met Gln Ala Ala Arg Gly Ser Leu 
             340                345                350
Ala Asn His Thr Ser Ile Ala Glu Leu Ile Lys Asp Val Thr Thr Ser 
         355                360                365
Glu Asp Phe Phe Asp Lys Leu Thr Val Glu Gln Glu Phe Met Ser Gly 
     370                375                380
Ile Asp Thr Asp Lys Val Asn Asn Tyr Ile Glu Asp Cys Ile Ala Gln 
 385                390                395                400
Lys His Pro Leu Ile Lys Val Leu Arg Leu Val Cys Leu Gln Ser Met 
                 405                410                415
Cys Asn Ser Gly Leu Lys Gln Lys Val Leu Asp Tyr Tyr Lys Arg Glu 
             420                425                430
Ile Leu Gln Thr Tyr Gly Tyr Glu His Ile Leu Thr Leu Asn Asn Leu 
         435                440                445
Glu Lys Ala Gly Leu Leu Lys Ala Gln Thr Gly Gly Arg Asn Asn Tyr 
     450                455                460
Pro Thr Ile Arg Lys Thr Leu Arg Leu Trp Met Asp Asp Val Asn Glu 
 465                470                475                480
Gln Asn Pro Thr Asp Ile Ser Tyr Val Tyr Ser Gly Tyr Ala Pro Leu 
                 485                490                495
Ser Val Arg Leu Ala Gln Leu Leu Ser Arg Pro Gly Trp Arg Ser Ile 
             500                505                510
Glu Glu Val Leu Arg Ile Leu Pro Gly Pro His Phe Glu Glu Arg Gln 
         515                520                525
Pro Leu Pro Thr Gly Val Gln Lys Lys Arg Gln Pro Gly Glu Asn Arg 
     530                535                540
Val Thr Leu Val Phe Phe Leu Gly Gly Val Thr Phe Ala Glu Ile Ala 
 545                550                555                560
Ala Leu Arg Phe Leu Ser Gln Leu Glu Asp Gly Gly Thr Glu Tyr Val 
                 565                570                575
Ile Ala Thr Thr Lys Leu Ile Asn Gly Ser Ser Trp Leu Glu Ala Leu 
             580                585                590
Met Glu Lys Pro Phe 
         595



<210> 8433
<211> 2536
<212> DNA
<213> Homo sapiens
<308> NM_022916
<400> 8433

ggcaggggg  ggtggagca  gatggcggc  catctgtcc  acggccgag  gaacctaaa  60
gtgttgcgc  aggcggtgc  tcgcgagct  cgcgagttc  tggacaagt  cgcaggaag  120
aaggcaata  tttgggatg  atacctaac  ggacccttt  gcctgattg  acagtattc  180
ctattgaag  aacatgaag  ggaaaaaat  ttcacactt  aaggaaatc  tttgccggc  240
gctgatgtg  agaatataa  tttttttgt  agacccagg  tagagttga  ggatataat  300
gctgaaaac  tgctcagtg  agatagacg  ggcccaacg  gagattttc  tattctgtt  360
gtgccacgc  gtagcctgt  gtgcgaaca  cggttgaag  atctgggtg  cttgggatc  420
tttattcac  gggaggagt  cagcttaga  ctcattcca  tcgatgggg  tctcttatc  480
atggaatca  agggtgcat  caaagagtg  tacctggag  gtgaccaga  gagcctgta  540
cacgcagcc  aggggctga  gaccctgca  gctctgtat  gaacgatcc  ccagatctt  600
gggaaagga  aatgcgctc  gcaagtggc  aatatgatg  tcaggatga  gagagagtt  660
acaggaagc  agaattcaa  atttcctgt  tttgataat  tcttgttgc  tgatcggaa  720
gtggattta  taacacctc  tgccactca  ctgacatat  aaggactca  tgatgaaat  780
tatggcatt  agaacagtt  tgtgaaatt  cctccagag  aatttgcac  taagaaaca  840
ggcgatggt  gtaaggacc  ccccacgga  gcaaagaag  tgcagctga  ttctgcaga  900
gagctctat  ctgagatcc  agataagaa  ttcaacgca  ttggctctg  gctcagcaa  960
aaagcaaag  tcatctctg  agcattcga  gaaagacac  atgctaaga  cgtggggga  1020
atcaagcag  ttgtttccc  gttgcccca  atgcaggca  caaggggct  gcttgcaaa  1080
catacctca  ttgcagaat  gatcaaaga  gtcactact  ctgaagact  ttttgataa  1140
ttaaccgtg  aacaggagt  tatgtctgg  atagacact  ataaggtca  caattacat  1200
gaggattgt  tcgcccaaa  gcactcgtt  atcaaggtg  taagactag  ttgcctcca  1260
tccgtgtgt  atagtgggc  caaacaaaa  gttttggat  attacaaaa  agagattct  1320
cagacatac  gctatgagc  catattgac  ttacacaac  tggagaagg  cggcctgct  1380
aaaccgcag  cggggggca  aaacaatta  ccaactata  ggaaaacat  acgcctctg  1440
atggatgat  ttaatgagc  aaaccccac  gacatatcg  atgtgtaca  tgggtatgc  1500
ccgctcagt  tgcggctgg  ccagctgct  tcccggcct  gctggcgga  catcgagga  1560
gtcctccgc  tcctcccag  gccccactt  gaggagcgg  agccactgc  cacaggact  1620
cagaagaaa  gtcaaccgg  agaaaaccg  gtgactctg  tatttttcc  tgggggcgt  1680
accttcgct  aaattgctg  cctgcgatt  ctctcccag  tggaagatg  aggtacaga  1740
tatgtcatt  ccaccacta  actaatgaa  ggaaccagt  ggatagagg  tctgatgga  1800
aaacctttc  aggatgttc  gaggagact  aacaagtgt  ctgcagaat  aactacctc  1860
ttgaagaaa  tgctgaaag  aagtaaaac  ccatagaag  aacatggga  tacagaata  1920
attctgggg  cagcttctt  aattatact  ctgtttact  ctttctccg  ctcttttgt  1980
ttccctttt  ttttttcct  tgagacgga  tcttgctct  tcacccaga  tagagtgca  2040
tggcacggt  tcacctcac  gcaacctcc  cctcctagg  tcaagcaat  ctcctgcct  2100
agcctcctg  gtagctggg  ctacaggca  gcaccacca  acccggcta  tttttgtat  2160
tttagtagc  atggtgttt  accatgttg  ccaggctgg  ctcaaactc  tgacctcag  2220
tgatccacc  gcctcggcc  cccacagtg  tgggattac  ggcctgagc  accgtgcct  2280
gcccctaat  tgctgaaga  agaagaata  aagaaaatc  acctgagta  aagcagcac  2340
ggttttgag  tttctaagc  cagggtctt  attagagac  tctggaaat  cattaagga  2400
ggtgggggt  gataatcca  tcagccaga  aaacggggc  agctcttaa  ataagaaag  2460
tgagactga  gaggtgaaa  tgaaaataa  aagagaaag  tcatcctct  aaaaaaaaa  2520
aaaaaaaaa  aaaaaa  2536



<210> 8434
<211> 596
<212> PRT
<213> Homo sapiens
<308> NP_075067
<400> 8434

Met Ala Ala His Leu Ser Tyr Gly Arg Val Asn Leu Asn Val Leu Arg 
  1               5                  10                  15
Glu Ala Val Arg Arg Glu Leu Arg Glu Phe Leu Asp Lys Cys Ala Gly 
             20                  25                  30
Ser Lys Ala Ile Val Trp Asp Glu Tyr Leu Thr Gly Pro Phe Gly Leu 
         35                  40                  45
Ile Ala Gln Tyr Ser Leu Leu Lys Glu His Glu Val Glu Lys Met Phe 
     50                  55                  60
Thr Leu Lys Gly Asn Arg Leu Pro Ala Ala Asp Val Lys Asn Ile Ile 
 65                  70                  75                  80
Phe Phe Val Arg Pro Arg Leu Glu Leu Met Asp Ile Ile Ala Glu Asn 
                 85                  90                  95
Val Leu Ser Glu Asp Arg Arg Gly Pro Thr Arg Asp Phe His Ile Leu 
             100                105                110
Phe Val Pro Arg Arg Ser Leu Leu Cys Glu Gln Arg Leu Lys Asp Leu 
         115                120                125
Gly Val Leu Gly Ser Phe Ile His Arg Glu Glu Tyr Ser Leu Asp Leu 
     130                135                140
Ile Pro Phe Asp Gly Asp Leu Leu Ser Met Glu Ser Glu Gly Ala Phe 
 145                150                155                160
Lys Glu Cys Tyr Leu Glu Gly Asp Gln Thr Ser Leu Tyr His Ala Ala 
                 165                170                175
Lys Gly Leu Met Thr Leu Gln Ala Leu Tyr Gly Thr Ile Pro Gln Ile 
             180                185                190
Phe Gly Lys Gly Glu Cys Ala Arg Gln Val Ala Asn Met Met Ile Arg 
         195                200                205
Met Lys Arg Glu Phe Thr Gly Ser Gln Asn Ser Ile Phe Pro Val Phe 
     210                215                220
Asp Asn Leu Leu Leu Leu Asp Arg Asn Val Asp Leu Leu Thr Pro Leu 
 225                230                235                240
Ala Thr Gln Leu Thr Tyr Glu Gly Leu Ile Asp Glu Ile Tyr Gly Ile 
                 245                250                255
Gln Asn Ser Tyr Val Lys Leu Pro Pro Glu Lys Phe Ala Pro Lys Lys 
             260                265                270
Gln Gly Asp Gly Gly Lys Asp Leu Pro Thr Glu Ala Lys Lys Leu Gln 
         275                280                285
Leu Asn Ser Ala Glu Glu Leu Tyr Ala Glu Ile Arg Asp Lys Asn Phe 
     290                295                300
Asn Ala Val Gly Ser Val Leu Ser Lys Lys Ala Lys Ile Ile Ser Ala 
 305                310                315                320
Ala Phe Glu Glu Arg His Asn Ala Lys Thr Val Gly Glu Ile Lys Gln 
                 325                330                335
Phe Val Ser Gln Leu Pro His Met Gln Ala Ala Arg Gly Ser Leu Ala 
             340                345                350
Asn His Thr Ser Ile Ala Glu Leu Ile Lys Asp Val Thr Thr Ser Glu 
         355                360                365
Asp Phe Phe Asp Lys Leu Thr Val Glu Gln Glu Phe Met Ser Gly Ile 
     370                375                380
Asp Thr Asp Lys Val Asn Asn Tyr Ile Glu Asp Cys Ile Ala Gln Lys 
 385                390                395                400
His Ser Leu Ile Lys Val Leu Arg Leu Val Cys Leu Gln Ser Val Cys 
                 405                410                415
Asn Ser Gly Leu Lys Gln Lys Val Leu Asp Tyr Tyr Lys Arg Glu Ile 
             420                425                430
Leu Gln Thr Tyr Gly Tyr Glu His Ile Leu Thr Leu His Asn Leu Glu 
         435                440                445
Lys Ala Gly Leu Leu Lys Pro Gln Thr Gly Gly Arg Asn Asn Tyr Pro 
     450                455                460
Thr Ile Arg Lys Thr Leu Arg Leu Trp Met Asp Asp Val Asn Glu Gln 
 465                470                475                480
Asn Pro Thr Asp Ile Ser Tyr Val Tyr Ser Gly Tyr Ala Pro Leu Ser 
                 485                490                495
Val Arg Leu Ala Gln Leu Leu Ser Arg Pro Gly Trp Arg Ser Ile Glu 
             500                505                510
Glu Val Leu Arg Ile Leu Pro Gly Pro His Phe Glu Glu Arg Gln Pro 
         515                520                525
Leu Pro Thr Gly Leu Gln Lys Lys Arg Gln Pro Gly Glu Asn Arg Val 
     530                535                540
Thr Leu Ile Phe Phe Leu Gly Gly Val Thr Phe Ala Glu Ile Ala Ala 
 545                550                555                560
Leu Arg Phe Leu Ser Gln Leu Glu Asp Gly Gly Thr Glu Tyr Val Ile 
                 565                570                575
Ala Thr Thr Lys Leu Met Asn Gly Thr Ser Trp Ile Glu Ala Leu Met 
             580                585                590
Glu Lys Pro Phe 
         595



<210> 8435
<211> 2051
<212> DNA
<213> Rattus norvegicus
<308> U35245
<400> 8435

cggcggtgg  tcaggtgac  tctcccatg  ctttccccc  tcgactgga  gcccctgag  60
ttcccgact  ctctatgct  aagaggctg  ctcgggacc  gctcatcta  ctgctagaa  120
agcttcctg  gaaaaagga  ttgttcatt  aggcagatc  catgagccc  ttggatcga  180
ttgctaacg  ctctatcct  aagcaacat  aagtagaca  gctgtacaa  gtggaaaac  240
aacttactc  cagctccaa  gaacaattg  gcttcttgg  cagacctcg  atcaagact  300
tgcgctaca  tgccaatct  gtcaatgct  acaaactgg  tggccgagt  agaaaatac  360
aaatcatct  aagtcctca  aagttttat  catgtgaga  ggtgcttga  gaagaggga  420
tctatggag  tgtgagctg  gatgaatgg  ccttttctc  gctgcctct  gatgtggat  480
tgctgagca  ggaactgcc  gaatttttc  gggattact  cctggaagg  gatcagcgt  540
ggatcaaca  ggtggctca  gccttgcac  ttctcagta  tctctatgg  cccttccct  600
actgctatg  cattggcag  tgcacgaag  tgtcatatg  cctgtggag  aaactggag  660
aggaagagg  cagtgaaac  aaaggtcgg  gaccagaga  tggacacat  tttctcttg  720
acagagatg  ggactttgt  acagcactt  gctcccaag  ggtttatga  ggcttggta  780
atgacacct  ccgaatcaa  tgtggaagt  tcgactttg  cccagaagt  acatcctct  840
acaagagcc  gaaggtgct  ctcaacgct  aggacaagg  gttcagtga  atccgcaat  900
agcacttct  caatgtctt  ggcttcttg  gccagaaag  ccggaactt  caggctcaa  960
atgaccgcc  gagaggtat  gacataaag  agatgaaga  cttcgtgtc  caagagctc  1020
agggactga  acaggagca  cgccttctg  gtctccata  tggagcttg  gaatcaatc  1080
tgaagaaga  aaccaagca  gacttccag  agctaatca  gaccgagca  gcactgctg  1140
agggcttca  cattcgaga  agcactagc  acattgaag  acacataga  cggcaggtg  1200
cgcccatag  aagcctacg  ctcatgtgc  ttttgtcca  cactgagaa  ggtttgatt  1260
ccaaggatt  tcggtccct  aaaacacag  atctgcaga  ctacggccc  gagcacctg  1320
taaccttct  caaccttcg  agagccggg  ttctaacag  gcaggcttc  ggggacacc  1380
tcactgcag  agagaataa  gtgagcaag  tggtgactg  caaggccgc  ggaaaaatc  1440
ctgatgcct  cagttctct  gccaagagg  gcaattttc  tgccatcag  aaaaagctg  1500
atttgatcc  acgtgtaga  ggggagtat  acctgaaag  gccccggga  atggcttac  1560
tcttcagtg  cgcctacgt  cctctgagc  gccgaatca  tgagcaggt  ctggaccgg  1620
ggagttggc  gggcctaga  gaagtggtc  ggctgctaa  ctgcagtga  tttgcattc  1680
cagacatgg  taaggaaga  aaggcttcc  gtgagtcac  ccgcctcat  ttggtggtg  1740
tcttggggg  ctgcacgtt  tcagagata  cagccctgc  cttcctggg  agagagaaa  1800
ggtacagat  tatttttct  acaactgct  ttacaaaca  tgctcgcct  atggaagcc  1860
tgagtgagg  gaaatcctg  tgctttcct  gccagtgcg  aagtaattc  tgattgtgg  1920
ccccagtga  aagctggtg  ttcacatct  ccttctaag  ctcccccaa  acacacatc  1980
tacctccca  ctatactct  cagaactgg  aacttcaga  ctaattttc  ggagagaat  2040
cgatatcaa  t  2051



<210> 8436
<211> 617
<212> PRT
<213> Rattus norvegicus
<308> AAC52986
<400> 8436

Met Ala Phe Pro His Arg Leu Asp Ala Pro Glu Leu Pro Asp Phe Ser 
  1               5                  10                  15
Met Leu Lys Arg Leu Ala Arg Asp Gln Leu Ile Tyr Leu Leu Glu Gln 
             20                  25                  30
Leu Pro Gly Lys Lys Asp Leu Phe Ile Glu Ala Asp Leu Met Ser Pro 
         35                  40                  45
Leu Asp Arg Ile Ala Asn Val Ser Ile Leu Lys Gln His Glu Val Asp 
     50                  55                  60
Lys Leu Tyr Lys Val Glu Asn Lys Leu Thr Leu Ser Ser Asn Glu Gln 
 65                  70                  75                  80
Leu Cys Phe Leu Val Arg Pro Arg Ile Lys Thr Met Arg Tyr Ile Ala 
                 85                  90                  95
Asn Leu Val Asn Ala Asp Lys Leu Ala Gly Arg Val Arg Lys Tyr Lys 
             100                105                110
Ile Ile Leu Ser Pro Gln Lys Phe Tyr Ala Cys Glu Met Val Leu Glu 
         115                120                125
Glu Glu Gly Val Tyr Gly Asp Val Ser Cys Asp Glu Trp Ala Phe Ser 
     130                135                140
Leu Leu Pro Leu Asp Val Asp Leu Leu Ser Met Glu Leu Pro Glu Phe 
 145                150                155                160
Phe Arg Asp Tyr Phe Leu Glu Gly Asp Gln Arg Trp Ile Asn Thr Val 
                 165                170                175
Ala Gln Ala Leu His Leu Leu Ser Thr Leu Tyr Gly Pro Phe Pro Asn 
             180                185                190
Cys Tyr Gly Ile Gly Arg Cys Thr Lys Met Ser Tyr Asp Leu Trp Arg 
         195                200                205
Lys Leu Glu Glu Glu Glu Asp Ser Glu Thr Lys Gly Arg Arg Pro Glu 
     210                215                220
Ile Gly His Ile Phe Leu Leu Asp Arg Asp Val Asp Phe Val Thr Ala 
 225                230                235                240
Leu Cys Ser Gln Val Val Tyr Glu Gly Leu Val Asp Asp Thr Phe Arg 
                 245                250                255
Ile Lys Cys Gly Ser Val Asp Phe Gly Pro Glu Val Thr Ser Ser Asp 
             260                265                270
Lys Ser Leu Lys Val Leu Leu Asn Ala Glu Asp Lys Val Phe Ser Glu 
         275                280                285
Ile Arg Asn Glu His Phe Ser Asn Val Phe Gly Phe Leu Ser Gln Lys 
     290                295                300
Ala Arg Asn Leu Gln Ala Gln Tyr Asp Arg Arg Arg Gly Met Asp Ile 
 305                310                315                320
Lys Gln Met Lys Asn Phe Val Ser Gln Glu Leu Lys Gly Leu Lys Gln 
                 325                330                335
Glu His Arg Leu Leu Ser Leu His Ile Gly Ala Cys Glu Ser Ile Met 
             340                345                350
Lys Lys Lys Thr Lys Gln Asp Phe Gln Glu Leu Ile Lys Thr Glu His 
         355                360                365
Ala Leu Leu Glu Gly Phe Asn Ile Arg Glu Ser Thr Ser Tyr Ile Glu 
     370                375                380
Glu His Ile Asp Arg Gln Val Ser Pro Ile Glu Ser Leu Arg Leu Met 
 385                390                395                400
Cys Leu Leu Ser Ile Thr Glu Asn Gly Leu Ile Pro Lys Asp Tyr Arg 
                 405                410                415
Ser Leu Lys Thr Gln Tyr Leu Gln Ser Tyr Gly Pro Glu His Leu Leu 
             420                425                430
Thr Phe Ser Asn Leu Arg Arg Ala Gly Leu Leu Thr Glu Gln Ala Ser 
         435                440                445
Gly Asp Thr Leu Thr Ala Val Glu Asn Lys Val Ser Lys Leu Val Thr 
     450                455                460
Asp Lys Ala Ala Gly Lys Ile Thr Asp Ala Phe Ser Ser Leu Ala Lys 
 465                470                475                480
Arg Ser Asn Phe Arg Ala Ile Ser Lys Lys Leu Asn Leu Ile Pro Arg 
                 485                490                495
Val Asp Gly Glu Tyr Asp Leu Lys Val Pro Arg Asp Met Ala Tyr Val 
             500                505                510
Phe Ser Gly Ala Tyr Val Pro Leu Ser Cys Arg Ile Ile Glu Gln Val 
         515                520                525
Leu Asp Arg Arg Ser Trp Gln Gly Leu Asp Glu Val Val Arg Leu Leu 
     530                535                540
Asn Cys Ser Asp Phe Ala Phe Thr Asp Met Ala Lys Glu Asp Lys Ala 
 545                550                555                560
Ser Ser Glu Ser Leu Arg Leu Ile Leu Val Val Phe Leu Gly Gly Cys 
                 565                570                575
Thr Phe Ser Glu Ile Ser Ala Leu Arg Phe Leu Gly Arg Glu Lys Gly 
             580                585                590
Tyr Arg Phe Ile Phe Leu Thr Thr Ala Val Thr Asn Ser Ala Arg Leu 
         595                600                605
Met Glu Ala Met Ser Glu Val Lys Ser 
     610                615



<210> 8437
<211> 1913
<212> DNA
<213> Homo sapiens
<308> AL357472
<400> 8437

caagaatat  cgatacatt  ccagtcttg  caatgctga  aaattggct  gccgaactc  60
caaatacaa  gtgatcttc  gccctcaaa  gttctatgc  tgtgagatg  tgcttgagg  120
agagggaat  tatggagat  tgagctgtg  tgaatgggc  ttctctttg  tgcctcttg  180
tgtggatct  ctgagcatg  aactaccag  atttttcag  gattacttt  tggaaggag  240
tcagcgttg  atcaacact  tagctcagg  cttacacct  ctcagcact  tctatggac  300
ctttccaaa  tgctatgga  ttggcaggt  cgccaagat  gcatatgaa  tgtggagga  360
cctggagga  gaggaggat  gcgaaacca  gggccgaag  ccagagatt  gacatatct  420
tctcttgga  agagatgtg  actttgtga  agcactttg  tcccaagtg  tttatgagg  480
cctagtaga  gacaccttc  gcatcaagt  tgggagtgt  gactttggc  cagaagtca  540
atcctctga  aagagcctg  aggtgctac  caatgccga  gacaaggtg  ttaatgaga  600
tcggaacga  cacttctcc  atgtctttg  cttcttgag  cagaaggcc  ggaacttgc  660
ggcccagta  gatcgccgg  gaggcatgg  cattaagca  atgaagaat  tcgtgtccc  720
agagctcaa  ggcctgaaa  aggagcacc  cctgctgag  ctccatatt  gggcctgtg  780
atccatcat  aagaagaaa  ccaagcagg  tttccagga  ctaatcaag  ctgagcatg  840
actgctaga  gggttcaac  tccgggaga  caccagcta  attgaggaa  acatagacc  900
gcaggtgtc  cctatagaa  gcctgcgcc  catgtgcct  ttgtccatc  ctgagaatg  960
tttgatccc  aaggattac  gatctctga  aacacagta  ctgcagagc  atggccctg  1020
gcacctgct  accttctcc  atctgcgaa  agctgggct  ctaacggag  aggcccccg  1080
ggacaccct  acagccgtg  agagtaaag  gagcaagct  gtgaccgac  aggctgcag  1140
aaagattac  gatgccttc  gttctctgg  caagaggag  aattttcgt  ccatcagca  1200
aaagctgaa  ttgatccca  gtgtggacg  cgagtatga  ctgaaagtg  cccgagaca  1260
ggcttacgt  ttcggtggt  cttatgtgc  cctgagctg  cgaatcatt  agcaggtgc  1320
agagcggcg  agctggcag  gccttgatg  ggtggtacg  ctgctcaac  gcagtgact  1380
tgcattcac  gatatgact  aggaagaca  ggcttccag  gagtccctg  gcctcatct  1440
ggtggtgtt  ttgggtggt  gtacattct  tgagatctc  gccctccgg  tcctgggca  1500
agagaaagg  tacaggttc  ttttcctga  gacagcagt  acaaacagc  ctcgcctta  1560
ggaggccat  agtgaggtg  aagcctgat  tttttcccg  ccagtgttg  catcttccc  1620
gaacacatt  ctcagtgag  tgcaggcat  tggcaccca  ctgctataa  caagtgtcc  1680
ccaactacc  gctaagagc  gggagcatg  aacgtgttg  gatttagag  acattatct  1740
agaaaagag  tcacttcct  ctcccagga  atttctctt  tctgtttat  aagtacaac  1800
catgctgct  agatgcgag  aggaagagg  atcctttgc  aaatcctgt  tgaatgtca  1860
tgtaaataa  gcctctgct  tcagatgta  aaaaaaaaa  aaaaaaaaa  aaa  1913



<210> 8438
<211> 617
<212> PRT
<213> Homo sapiens
<308> AAG34680
<400> 8438

Met Ala Phe Pro His Arg Pro Asp Ala Pro Glu Leu Pro Asp Phe Ser 
  1               5                  10                  15
Met Leu Lys Arg Leu Ala Arg Asp Gln Leu Ile Tyr Leu Leu Glu Gln 
             20                  25                  30
Leu Pro Gly Lys Lys Asp Leu Phe Ile Glu Ala Asp Leu Met Ser Pro 
         35                  40                  45
Leu Asp Arg Ile Ala Asn Val Ser Ile Leu Lys Gln His Glu Val Asp 
     50                  55                  60
Lys Leu Tyr Lys Val Glu Asn Lys Pro Ala Leu Ser Ser Asn Glu Gln 
 65                  70                  75                  80
Leu Cys Phe Leu Val Arg Pro Arg Ile Lys Asn Met Arg Tyr Ile Ala 
                 85                  90                  95
Ser Leu Val Asn Ala Asp Lys Leu Ala Gly Arg Thr Arg Lys Tyr Lys 
             100                105                110
Val Ile Phe Ser Pro Gln Lys Phe Tyr Ala Cys Glu Met Val Leu Glu 
         115                120                125
Glu Glu Gly Ile Tyr Gly Asp Val Ser Cys Asp Glu Trp Ala Phe Ser 
     130                135                140
Leu Leu Pro Leu Asp Val Asp Leu Leu Ser Met Glu Leu Pro Glu Phe 
 145                150                155                160
Phe Arg Asp Tyr Phe Leu Glu Gly Asp Gln Arg Trp Ile Asn Thr Val 
                 165                170                175
Ala Gln Ala Leu His Leu Leu Ser Thr Leu Tyr Gly Pro Phe Pro Asn 
             180                185                190
Cys Tyr Gly Ile Gly Arg Cys Ala Lys Met Ala Tyr Glu Leu Trp Arg 
         195                200                205
Asn Leu Glu Glu Glu Glu Asp Gly Glu Thr Lys Gly Arg Arg Pro Glu 
     210                215                220
Ile Gly His Ile Phe Leu Leu Asp Arg Asp Val Asp Phe Val Thr Ala 
 225                230                235                240
Leu Cys Ser Gln Val Val Tyr Glu Gly Leu Val Asp Asp Thr Phe Arg 
                 245                250                255
Ile Lys Cys Gly Ser Val Asp Phe Gly Pro Glu Val Thr Ser Ser Asp 
             260                265                270
Lys Ser Leu Lys Val Leu Leu Asn Ala Glu Asp Lys Val Phe Asn Glu 
         275                280                285
Ile Arg Asn Glu His Phe Ser Asn Val Phe Gly Phe Leu Ser Gln Lys 
     290                295                300
Ala Arg Asn Leu Gln Ala Gln Tyr Asp Arg Arg Arg Gly Met Asp Ile 
 305                310                315                320
Lys Gln Met Lys Asn Phe Val Ser Gln Glu Leu Lys Gly Leu Lys Gln 
                 325                330                335
Glu His Arg Leu Leu Ser Leu His Ile Gly Ala Cys Glu Ser Ile Met 
             340                345                350
Lys Lys Lys Thr Lys Gln Asp Phe Gln Glu Leu Ile Lys Thr Glu His 
         355                360                365
Ala Leu Leu Glu Gly Phe Asn Ile Arg Glu Ser Thr Ser Tyr Ile Glu 
     370                375                380
Glu His Ile Asp Arg Gln Val Ser Pro Ile Glu Ser Leu Arg Leu Met 
 385                390                395                400
Cys Leu Leu Ser Ile Thr Glu Asn Gly Leu Ile Pro Lys Asp Tyr Arg 
                 405                410                415
Ser Leu Lys Thr Gln Tyr Leu Gln Ser Tyr Gly Pro Glu His Leu Leu 
             420                425                430
Thr Phe Ser Asn Leu Arg Arg Ala Gly Leu Leu Thr Glu Gln Ala Pro 
         435                440                445
Gly Asp Thr Leu Thr Ala Val Glu Ser Lys Val Ser Lys Leu Val Thr 
     450                455                460
Asp Lys Ala Ala Gly Lys Ile Thr Asp Ala Phe Ser Ser Leu Ala Lys 
 465                470                475                480
Arg Ser Asn Phe Arg Ala Ile Ser Lys Lys Leu Asn Leu Ile Pro Arg 
                 485                490                495
Val Asp Gly Glu Tyr Asp Leu Lys Val Pro Arg Asp Met Ala Tyr Val 
             500                505                510
Phe Ser Gly Ala Tyr Val Pro Leu Ser Cys Arg Ile Ile Glu Gln Val 
         515                520                525
Leu Glu Arg Arg Ser Trp Gln Gly Leu Asp Glu Val Val Arg Leu Leu 
     530                535                540
Asn Cys Ser Asp Phe Ala Phe Thr Asp Met Thr Lys Glu Asp Lys Ala 
 545                550                555                560
Ser Ser Glu Ser Leu Arg Leu Ile Leu Val Val Phe Leu Gly Gly Cys 
                 565                570                575
Thr Phe Ser Glu Ile Ser Ala Leu Arg Phe Leu Gly Arg Glu Lys Gly 
             580                585                590
Tyr Arg Phe Ile Phe Leu Thr Thr Ala Val Thr Asn Ser Ala Arg Leu 
         595                600                605
Met Glu Ala Met Ser Glu Val Lys Ala 
     610                615



<210> 8439
<211> 2051
<212> DNA
<213> Rattus norvegicus
<308> U35245
<400> 8439

cggcggtgg  tcaggtgac  tctcccatg  ctttccccc  tcgactgga  gcccctgag  60
ttcccgact  ctctatgct  aagaggctg  ctcgggacc  gctcatcta  ctgctagaa  120
agcttcctg  gaaaaagga  ttgttcatt  aggcagatc  catgagccc  ttggatcga  180
ttgctaacg  ctctatcct  aagcaacat  aagtagaca  gctgtacaa  gtggaaaac  240
aacttactc  cagctccaa  gaacaattg  gcttcttgg  cagacctcg  atcaagact  300
tgcgctaca  tgccaatct  gtcaatgct  acaaactgg  tggccgagt  agaaaatac  360
aaatcatct  aagtcctca  aagttttat  catgtgaga  ggtgcttga  gaagaggga  420
tctatggag  tgtgagctg  gatgaatgg  ccttttctc  gctgcctct  gatgtggat  480
tgctgagca  ggaactgcc  gaatttttc  gggattact  cctggaagg  gatcagcgt  540
ggatcaaca  ggtggctca  gccttgcac  ttctcagta  tctctatgg  cccttccct  600
actgctatg  cattggcag  tgcacgaag  tgtcatatg  cctgtggag  aaactggag  660
aggaagagg  cagtgaaac  aaaggtcgg  gaccagaga  tggacacat  tttctcttg  720
acagagatg  ggactttgt  acagcactt  gctcccaag  ggtttatga  ggcttggta  780
atgacacct  ccgaatcaa  tgtggaagt  tcgactttg  cccagaagt  acatcctct  840
acaagagcc  gaaggtgct  ctcaacgct  aggacaagg  gttcagtga  atccgcaat  900
agcacttct  caatgtctt  ggcttcttg  gccagaaag  ccggaactt  caggctcaa  960
atgaccgcc  gagaggtat  gacataaag  agatgaaga  cttcgtgtc  caagagctc  1020
agggactga  acaggagca  cgccttctg  gtctccata  tggagcttg  gaatcaatc  1080
tgaagaaga  aaccaagca  gacttccag  agctaatca  gaccgagca  gcactgctg  1140
agggcttca  cattcgaga  agcactagc  acattgaag  acacataga  cggcaggtg  1200
cgcccatag  aagcctacg  ctcatgtgc  ttttgtcca  cactgagaa  ggtttgatt  1260
ccaaggatt  tcggtccct  aaaacacag  atctgcaga  ctacggccc  gagcacctg  1320
taaccttct  caaccttcg  agagccggg  ttctaacag  gcaggcttc  ggggacacc  1380
tcactgcag  agagaataa  gtgagcaag  tggtgactg  caaggccgc  ggaaaaatc  1440
ctgatgcct  cagttctct  gccaagagg  gcaattttc  tgccatcag  aaaaagctg  1500
atttgatcc  acgtgtaga  ggggagtat  acctgaaag  gccccggga  atggcttac  1560
tcttcagtg  cgcctacgt  cctctgagc  gccgaatca  tgagcaggt  ctggaccgg  1620
ggagttggc  gggcctaga  gaagtggtc  ggctgctaa  ctgcagtga  tttgcattc  1680
cagacatgg  taaggaaga  aaggcttcc  gtgagtcac  ccgcctcat  ttggtggtg  1740
tcttggggg  ctgcacgtt  tcagagata  cagccctgc  cttcctggg  agagagaaa  1800
ggtacagat  tatttttct  acaactgct  ttacaaaca  tgctcgcct  atggaagcc  1860
tgagtgagg  gaaatcctg  tgctttcct  gccagtgcg  aagtaattc  tgattgtgg  1920
ccccagtga  aagctggtg  ttcacatct  ccttctaag  ctcccccaa  acacacatc  1980
tacctccca  ctatactct  cagaactgg  aacttcaga  ctaattttc  ggagagaat  2040
cgatatcaa  t  2051



<210> 8440
<211> 617
<212> PRT
<213> Rattus norvegicus
<308> AAC52986
<400> 8440

Met Ala Phe Pro His Arg Leu Asp Ala Pro Glu Leu Pro Asp Phe Ser 
  1               5                  10                  15
Met Leu Lys Arg Leu Ala Arg Asp Gln Leu Ile Tyr Leu Leu Glu Gln 
             20                  25                  30
Leu Pro Gly Lys Lys Asp Leu Phe Ile Glu Ala Asp Leu Met Ser Pro 
         35                  40                  45
Leu Asp Arg Ile Ala Asn Val Ser Ile Leu Lys Gln His Glu Val Asp 
     50                  55                  60
Lys Leu Tyr Lys Val Glu Asn Lys Leu Thr Leu Ser Ser Asn Glu Gln 
 65                  70                  75                  80
Leu Cys Phe Leu Val Arg Pro Arg Ile Lys Thr Met Arg Tyr Ile Ala 
                 85                  90                  95
Asn Leu Val Asn Ala Asp Lys Leu Ala Gly Arg Val Arg Lys Tyr Lys 
             100                105                110
Ile Ile Leu Ser Pro Gln Lys Phe Tyr Ala Cys Glu Met Val Leu Glu 
         115                120                125
Glu Glu Gly Val Tyr Gly Asp Val Ser Cys Asp Glu Trp Ala Phe Ser 
     130                135                140
Leu Leu Pro Leu Asp Val Asp Leu Leu Ser Met Glu Leu Pro Glu Phe 
 145                150                155                160
Phe Arg Asp Tyr Phe Leu Glu Gly Asp Gln Arg Trp Ile Asn Thr Val 
                 165                170                175
Ala Gln Ala Leu His Leu Leu Ser Thr Leu Tyr Gly Pro Phe Pro Asn 
             180                185                190
Cys Tyr Gly Ile Gly Arg Cys Thr Lys Met Ser Tyr Asp Leu Trp Arg 
         195                200                205
Lys Leu Glu Glu Glu Glu Asp Ser Glu Thr Lys Gly Arg Arg Pro Glu 
     210                215                220
Ile Gly His Ile Phe Leu Leu Asp Arg Asp Val Asp Phe Val Thr Ala 
 225                230                235                240
Leu Cys Ser Gln Val Val Tyr Glu Gly Leu Val Asp Asp Thr Phe Arg 
                 245                250                255
Ile Lys Cys Gly Ser Val Asp Phe Gly Pro Glu Val Thr Ser Ser Asp 
             260                265                270
Lys Ser Leu Lys Val Leu Leu Asn Ala Glu Asp Lys Val Phe Ser Glu 
         275                280                285
Ile Arg Asn Glu His Phe Ser Asn Val Phe Gly Phe Leu Ser Gln Lys 
     290                295                300
Ala Arg Asn Leu Gln Ala Gln Tyr Asp Arg Arg Arg Gly Met Asp Ile 
 305                310                315                320
Lys Gln Met Lys Asn Phe Val Ser Gln Glu Leu Lys Gly Leu Lys Gln 
                 325                330                335
Glu His Arg Leu Leu Ser Leu His Ile Gly Ala Cys Glu Ser Ile Met 
             340                345                350
Lys Lys Lys Thr Lys Gln Asp Phe Gln Glu Leu Ile Lys Thr Glu His 
         355                360                365
Ala Leu Leu Glu Gly Phe Asn Ile Arg Glu Ser Thr Ser Tyr Ile Glu 
     370                375                380
Glu His Ile Asp Arg Gln Val Ser Pro Ile Glu Ser Leu Arg Leu Met 
 385                390                395                400
Cys Leu Leu Ser Ile Thr Glu Asn Gly Leu Ile Pro Lys Asp Tyr Arg 
                 405                410                415
Ser Leu Lys Thr Gln Tyr Leu Gln Ser Tyr Gly Pro Glu His Leu Leu 
             420                425                430
Thr Phe Ser Asn Leu Arg Arg Ala Gly Leu Leu Thr Glu Gln Ala Ser 
         435                440                445
Gly Asp Thr Leu Thr Ala Val Glu Asn Lys Val Ser Lys Leu Val Thr 
     450                455                460
Asp Lys Ala Ala Gly Lys Ile Thr Asp Ala Phe Ser Ser Leu Ala Lys 
 465                470                475                480
Arg Ser Asn Phe Arg Ala Ile Ser Lys Lys Leu Asn Leu Ile Pro Arg 
                 485                490                495
Val Asp Gly Glu Tyr Asp Leu Lys Val Pro Arg Asp Met Ala Tyr Val 
             500                505                510
Phe Ser Gly Ala Tyr Val Pro Leu Ser Cys Arg Ile Ile Glu Gln Val 
         515                520                525
Leu Asp Arg Arg Ser Trp Gln Gly Leu Asp Glu Val Val Arg Leu Leu 
     530                535                540
Asn Cys Ser Asp Phe Ala Phe Thr Asp Met Ala Lys Glu Asp Lys Ala 
 545                550                555                560
Ser Ser Glu Ser Leu Arg Leu Ile Leu Val Val Phe Leu Gly Gly Cys 
                 565                570                575
Thr Phe Ser Glu Ile Ser Ala Leu Arg Phe Leu Gly Arg Glu Lys Gly 
             580                585                590
Tyr Arg Phe Ile Phe Leu Thr Thr Ala Val Thr Asn Ser Ala Arg Leu 
         595                600                605
Met Glu Ala Met Ser Glu Val Lys Ser 
     610                615



<210> 8441
<211> 1913
<212> DNA
<213> Homo sapiens
<308> AL357472
<400> 8441

caagaatat  cgatacatt  ccagtcttg  caatgctga  aaattggct  gccgaactc  60
caaatacaa  gtgatcttc  gccctcaaa  gttctatgc  tgtgagatg  tgcttgagg  120
agagggaat  tatggagat  tgagctgtg  tgaatgggc  ttctctttg  tgcctcttg  180
tgtggatct  ctgagcatg  aactaccag  atttttcag  gattacttt  tggaaggag  240
tcagcgttg  atcaacact  tagctcagg  cttacacct  ctcagcact  tctatggac  300
ctttccaaa  tgctatgga  ttggcaggt  cgccaagat  gcatatgaa  tgtggagga  360
cctggagga  gaggaggat  gcgaaacca  gggccgaag  ccagagatt  gacatatct  420
tctcttgga  agagatgtg  actttgtga  agcactttg  tcccaagtg  tttatgagg  480
cctagtaga  gacaccttc  gcatcaagt  tgggagtgt  gactttggc  cagaagtca  540
atcctctga  aagagcctg  aggtgctac  caatgccga  gacaaggtg  ttaatgaga  600
tcggaacga  cacttctcc  atgtctttg  cttcttgag  cagaaggcc  ggaacttgc  660
ggcccagta  gatcgccgg  gaggcatgg  cattaagca  atgaagaat  tcgtgtccc  720
agagctcaa  ggcctgaaa  aggagcacc  cctgctgag  ctccatatt  gggcctgtg  780
atccatcat  aagaagaaa  ccaagcagg  tttccagga  ctaatcaag  ctgagcatg  840
actgctaga  gggttcaac  tccgggaga  caccagcta  attgaggaa  acatagacc  900
gcaggtgtc  cctatagaa  gcctgcgcc  catgtgcct  ttgtccatc  ctgagaatg  960
tttgatccc  aaggattac  gatctctga  aacacagta  ctgcagagc  atggccctg  1020
gcacctgct  accttctcc  atctgcgaa  agctgggct  ctaacggag  aggcccccg  1080
ggacaccct  acagccgtg  agagtaaag  gagcaagct  gtgaccgac  aggctgcag  1140
aaagattac  gatgccttc  gttctctgg  caagaggag  aattttcgt  ccatcagca  1200
aaagctgaa  ttgatccca  gtgtggacg  cgagtatga  ctgaaagtg  cccgagaca  1260
ggcttacgt  ttcggtggt  cttatgtgc  cctgagctg  cgaatcatt  agcaggtgc  1320
agagcggcg  agctggcag  gccttgatg  ggtggtacg  ctgctcaac  gcagtgact  1380
tgcattcac  gatatgact  aggaagaca  ggcttccag  gagtccctg  gcctcatct  1440
ggtggtgtt  ttgggtggt  gtacattct  tgagatctc  gccctccgg  tcctgggca  1500
agagaaagg  tacaggttc  ttttcctga  gacagcagt  acaaacagc  ctcgcctta  1560
ggaggccat  agtgaggtg  aagcctgat  tttttcccg  ccagtgttg  catcttccc  1620
gaacacatt  ctcagtgag  tgcaggcat  tggcaccca  ctgctataa  caagtgtcc  1680
ccaactacc  gctaagagc  gggagcatg  aacgtgttg  gatttagag  acattatct  1740
agaaaagag  tcacttcct  ctcccagga  atttctctt  tctgtttat  aagtacaac  1800
catgctgct  agatgcgag  aggaagagg  atcctttgc  aaatcctgt  tgaatgtca  1860
tgtaaataa  gcctctgct  tcagatgta  aaaaaaaaa  aaaaaaaaa  aaa  1913



<210> 8442
<211> 617
<212> PRT
<213> Homo sapiens
<308> AAG34680
<400> 8442

Met Ala Phe Pro His Arg Pro Asp Ala Pro Glu Leu Pro Asp Phe Ser 
  1               5                  10                  15
Met Leu Lys Arg Leu Ala Arg Asp Gln Leu Ile Tyr Leu Leu Glu Gln 
             20                  25                  30
Leu Pro Gly Lys Lys Asp Leu Phe Ile Glu Ala Asp Leu Met Ser Pro 
         35                  40                  45
Leu Asp Arg Ile Ala Asn Val Ser Ile Leu Lys Gln His Glu Val Asp 
     50                  55                  60
Lys Leu Tyr Lys Val Glu Asn Lys Pro Ala Leu Ser Ser Asn Glu Gln 
 65                  70                  75                  80
Leu Cys Phe Leu Val Arg Pro Arg Ile Lys Asn Met Arg Tyr Ile Ala 
                 85                  90                  95
Ser Leu Val Asn Ala Asp Lys Leu Ala Gly Arg Thr Arg Lys Tyr Lys 
             100                105                110
Val Ile Phe Ser Pro Gln Lys Phe Tyr Ala Cys Glu Met Val Leu Glu 
         115                120                125
Glu Glu Gly Ile Tyr Gly Asp Val Ser Cys Asp Glu Trp Ala Phe Ser 
     130                135                140
Leu Leu Pro Leu Asp Val Asp Leu Leu Ser Met Glu Leu Pro Glu Phe 
 145                150                155                160
Phe Arg Asp Tyr Phe Leu Glu Gly Asp Gln Arg Trp Ile Asn Thr Val 
                 165                170                175
Ala Gln Ala Leu His Leu Leu Ser Thr Leu Tyr Gly Pro Phe Pro Asn 
             180                185                190
Cys Tyr Gly Ile Gly Arg Cys Ala Lys Met Ala Tyr Glu Leu Trp Arg 
         195                200                205
Asn Leu Glu Glu Glu Glu Asp Gly Glu Thr Lys Gly Arg Arg Pro Glu 
     210                215                220
Ile Gly His Ile Phe Leu Leu Asp Arg Asp Val Asp Phe Val Thr Ala 
 225                230                235                240
Leu Cys Ser Gln Val Val Tyr Glu Gly Leu Val Asp Asp Thr Phe Arg 
                 245                250                255
Ile Lys Cys Gly Ser Val Asp Phe Gly Pro Glu Val Thr Ser Ser Asp 
             260                265                270
Lys Ser Leu Lys Val Leu Leu Asn Ala Glu Asp Lys Val Phe Asn Glu 
         275                280                285
Ile Arg Asn Glu His Phe Ser Asn Val Phe Gly Phe Leu Ser Gln Lys 
     290                295                300
Ala Arg Asn Leu Gln Ala Gln Tyr Asp Arg Arg Arg Gly Met Asp Ile 
 305                310                315                320
Lys Gln Met Lys Asn Phe Val Ser Gln Glu Leu Lys Gly Leu Lys Gln 
                 325                330                335
Glu His Arg Leu Leu Ser Leu His Ile Gly Ala Cys Glu Ser Ile Met 
             340                345                350
Lys Lys Lys Thr Lys Gln Asp Phe Gln Glu Leu Ile Lys Thr Glu His 
         355                360                365
Ala Leu Leu Glu Gly Phe Asn Ile Arg Glu Ser Thr Ser Tyr Ile Glu 
     370                375                380
Glu His Ile Asp Arg Gln Val Ser Pro Ile Glu Ser Leu Arg Leu Met 
 385                390                395                400
Cys Leu Leu Ser Ile Thr Glu Asn Gly Leu Ile Pro Lys Asp Tyr Arg 
                 405                410                415
Ser Leu Lys Thr Gln Tyr Leu Gln Ser Tyr Gly Pro Glu His Leu Leu 
             420                425                430
Thr Phe Ser Asn Leu Arg Arg Ala Gly Leu Leu Thr Glu Gln Ala Pro 
         435                440                445
Gly Asp Thr Leu Thr Ala Val Glu Ser Lys Val Ser Lys Leu Val Thr 
     450                455                460
Asp Lys Ala Ala Gly Lys Ile Thr Asp Ala Phe Ser Ser Leu Ala Lys 
 465                470                475                480
Arg Ser Asn Phe Arg Ala Ile Ser Lys Lys Leu Asn Leu Ile Pro Arg 
                 485                490                495
Val Asp Gly Glu Tyr Asp Leu Lys Val Pro Arg Asp Met Ala Tyr Val 
             500                505                510
Phe Ser Gly Ala Tyr Val Pro Leu Ser Cys Arg Ile Ile Glu Gln Val 
         515                520                525
Leu Glu Arg Arg Ser Trp Gln Gly Leu Asp Glu Val Val Arg Leu Leu 
     530                535                540
Asn Cys Ser Asp Phe Ala Phe Thr Asp Met Thr Lys Glu Asp Lys Ala 
 545                550                555                560
Ser Ser Glu Ser Leu Arg Leu Ile Leu Val Val Phe Leu Gly Gly Cys 
                 565                570                575
Thr Phe Ser Glu Ile Ser Ala Leu Arg Phe Leu Gly Arg Glu Lys Gly 
             580                585                590
Tyr Arg Phe Ile Phe Leu Thr Thr Ala Val Thr Asn Ser Ala Arg Leu 
         595                600                605
Met Glu Ala Met Ser Glu Val Lys Ala 
     610                615



<210> 8443
<211> 2246
<212> DNA
<213> Rattus norvegicus
<308> U35775
<400> 8443

ggcaggagt  ggatgtaga  cgctcctga  ttcaattcc  agcaaccac  cctagccgg  60
aagacggac  cgcgtcggc  cccctgcac  caaagcagc  ttggatcgc  tgcagggca  120
gaagactgg  agcatgagt  cagacagca  ccaagcggt  atcaccacc  ctcctcctc  180
cagcatgcc  cacaaagag  ggtattttg  ccgaatcaa  gaaagtgat  cagaatacc  240
ccgagagag  aacatgtct  ctgatctac  ggaggactt  aatatgatg  agcagagga  300
gcgagtcac  cagatcctg  agagtcctg  ctttcggga  gacctagag  gcctcaccc  360
agaacagat  aagaaaggc  acgacccga  cggattgct  gcgttacag  agatcgccg  420
ctacatcat  gccaactcc  tcaccggtt  ttcttcacc  cccctgagt  ttggcatgg  480
cactcctat  aatgacctt  ctggtgcag  cacatcctc  tatgtgaag  gagagaagc  540
cactcgttg  gaactcgcc  gcctgtaca  actcgcaga  ctgtttggg  gggcacatc  600
ggcaaatac  tacatctcg  tacgagtaa  taaggagca  gaccacatc  taatcatcc  660
cagaggcct  cctttctct  aagccacag  ctctgctct  gtgaaggtc  acataatag  720
agaagtggt  gaccagggg  gtactaatt  gaaaattga  cattcagga  tcagtcccc  780
tgctgcaat  tattcaacc  gtcccgatg  gaagtgtgt  atacacatc  acaccctcg  840
tacagcagc  gtgtcttcc  tgaagtgtg  gatccttcc  atttcccaa  agtctctca  900
cctgggaga  gtagcctat  atgactacc  ggggtcgct  gatgaggag  aggaaagaa  960
cgaacttca  aaagttctg  gtccaagct  taaggtgct  gtcctcagg  accatggcg  1020
ggtagctct  ggagaaaca  ttgaggagg  tttccacta  atcttcaat  tacagatgg  1080
ctgtgagat  caggtgcag  ctgtagcag  ggcaggggg  gtggacaat  ttctcatac  1140
ggatcttca  aaatacaaa  ctttcaccc  cggtgttgc  atgactgga  gaggcggtg  1200
gaatatggg  tcccatcag  agtggaaag  tggcgagat  gagtttgaa  ggctcatga  1260
aaccctgga  aacttgggc  acagaacag  ctacgcata  aggcatcct  tagttcgag  1320
gaagcctcg  cacaagagt  acgtggaga  cccagcaac  gtgactgca  tctcctttg  1380
agatgatag  gtgccactc  ctcccctca  gtacatggc  cagagacag  agcgtgaaa  1440
aacaagatg  ctgaattct  caaatacat  catgaaagt  aatgtgccg  aggagtccc  1500
gaacgggga  actagtccc  ggaccaaaa  aacgtggat  aaagcagag  acccctcta  1560
agttagtag  ggaacacct  tcaaaattg  agatcccaa  cagtttgtt  ctctaaaca  1620
gaacccgac  gaggtgctg  agaagagaa  taagattcg  gaacagaat  gctatgacc  1680
gaagacagc  gggccacag  ctcagctgc  ggcggggat  gttgtggac  aaccgcctt  1740
taccatgcg  tttgaagac  atgatcagg  cccaccagc  cctcctaac  cattcagtc  1800
tctcatgga  ggagaactt  aagaatata  gaagacaat  gagagacag  agcaaggcc  1860
ggacgaaaa  cacgagctg  tttccaaga  cttcacctc  gtggatgtg  ctgtcattg  1920
gaatggcaa  gacgagatg  acgatgttg  agacgagct  gctcagcgc  tcagcaggc  1980
cacgacgag  accaccata  agaacatcg  gatcaccat  aagtcccca  acagaactg  2040
agaggtcct  tcacccgat  gctcgcctt  aaagtcacc  tccaagaaa  agaagaaat  2100
ccgcacacc  tcttttctc  aaaagaaca  aaaaaaagg  gaaagttga  gcctaagta  2160
tctttctgt  atttgtaca  tacattgtg  cattgcaca  ttaaatacc  tattttagt  2220
aatcgttaa  atacggtgg  agagcc  2246



<210> 8444
<211> 705
<212> PRT
<213> Rattus norvegicus
<308> Q62847
<400> 8444

Met Ser Ser Asp Ser Ser Gln Ala Val Ile Thr Thr Pro Pro Pro Pro 
  1               5                  10                  15
Ser Met Pro His Lys Glu Arg Tyr Phe Asp Arg Ile Asn Glu Ser Asp 
             20                  25                  30
Pro Glu Tyr Leu Arg Glu Arg Asn Met Ser Pro Asp Leu Arg Glu Asp 
         35                  40                  45
Phe Asn Met Met Glu Gln Arg Lys Arg Val Thr Gln Ile Leu Gln Ser 
     50                  55                  60
Pro Ala Phe Arg Glu Asp Leu Glu Cys Leu Thr Gln Glu Gln Met Lys 
 65                  70                  75                  80
Lys Gly His Asp Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp 
                 85                  90                  95
Tyr Ile Met Ala Asn Ser Phe Thr Gly Phe Ser Ser Pro Pro Leu Ser 
             100                105                110
Leu Gly Met Val Thr Pro Ile Asn Asp Leu Pro Gly Ala Asp Thr Ser 
         115                120                125
Ser Tyr Val Lys Gly Glu Lys Leu Thr Arg Cys Glu Leu Ala Ser Leu 
     130                135                140
Tyr Arg Leu Ala Asp Leu Phe Gly Trp Ala His Leu Ala Asn Thr Tyr 
 145                150                155                160
Ile Ser Val Arg Val Ser Lys Glu Gln Asp His Ile Ile Ile Ile Pro 
                 165                170                175
Arg Gly Leu Pro Phe Ser Glu Ala Thr Ala Ser Ala Leu Val Lys Val 
             180                185                190
Asn Ile Ile Gly Glu Val Val Asp Gln Gly Ser Thr Asn Leu Lys Ile 
         195                200                205
Asp His Ser Gly Phe Ser Pro His Ala Ala Ile Tyr Ser Thr Arg Pro 
     210                215                220
Asp Val Lys Cys Val Ile His Ile His Thr Leu Ala Thr Ala Ala Val 
 225                230                235                240
Ser Ser Met Lys Cys Gly Ile Leu Pro Ile Ser Gln Glu Ser Leu Ile 
                 245                250                255
Leu Gly Asp Val Ala Tyr Tyr Asp Tyr Gln Gly Ser Leu Asp Glu Glu 
             260                265                270
Glu Glu Arg Ile Glu Leu Gln Lys Val Leu Gly Pro Ser Cys Lys Val 
         275                280                285
Leu Val Leu Arg Asn His Gly Val Val Ala Leu Gly Glu Thr Leu Glu 
     290                295                300
Glu Ala Phe His Tyr Ile Phe Asn Val Gln Met Ala Cys Glu Ile Gln 
 305                310                315                320
Val Gln Ala Val Ala Gly Ala Gly Gly Val Asp Asn Leu Leu Ile Leu 
                 325                330                335
Asp Leu Gln Lys Tyr Lys Ala Phe Thr His Gly Val Ala Met Thr Gly 
             340                345                350
Gly Gly Gly Val Asn Met Gly Ser His Gln Lys Trp Lys Val Gly Glu 
         355                360                365
Ile Glu Phe Glu Gly Leu Met Arg Thr Leu Asp Asn Leu Gly Tyr Arg 
     370                375                380
Thr Gly Tyr Ala Tyr Arg His Pro Leu Val Arg Glu Lys Pro Arg His 
 385                390                395                400
Lys Ser Asp Val Glu Ile Pro Ala Thr Val Thr Ala Phe Ser Phe Glu 
                 405                410                415
Asp Asp Ser Val Pro Leu Ser Pro Leu Lys Tyr Met Ala Gln Arg Gln 
             420                425                430
Gln Arg Glu Lys Thr Arg Trp Leu Asn Ser Pro Asn Thr Tyr Met Lys 
         435                440                445
Val Asn Val Pro Glu Glu Ser Arg Asn Gly Glu Thr Ser Pro Arg Thr 
     450                455                460
Lys Ile Thr Trp Met Lys Ala Glu Asp Pro Ser Lys Val Ser Ser Gly 
 465                470                475                480
Thr Pro Ile Lys Ile Glu Asp Pro Asn Gln Phe Val Pro Leu Asn Thr 
                 485                490                495
Asn Pro Thr Glu Val Leu Glu Lys Arg Asn Lys Ile Arg Glu Gln Asn 
             500                505                510
Arg Tyr Asp Leu Lys Thr Ala Gly Pro Gln Ser Gln Leu Leu Ala Gly 
         515                520                525
Ile Val Val Asp Lys Pro Pro Ser Thr Met Arg Phe Glu Asp Asp Asp 
     530                535                540
Gln Gly Pro Pro Ala Pro Pro Asn Pro Phe Ser His Leu Met Glu Gly 
 545                550                555                560
Glu Leu Glu Glu Tyr Thr Lys Thr Ile Glu Arg Gln Gln Gln Gly Leu 
                 565                570                575
Asp Asp Ala Glu Gln Glu Ser Leu Ser Asp Asp Ala Ala Ser Val Ser 
             580                585                590
Gln Ile Gln Ser Gln Thr Gln Ser Pro Gln Ser Val Pro Glu Arg Leu 
         595                600                605
Glu Glu Asn His Glu Leu Phe Ser Lys Ser Phe Thr Ser Val Asp Val 
     610                615                620
Pro Val Ile Val Asn Gly Lys Asp Glu Met His Asp Val Glu Asp Glu 
 625                630                635                640
Leu Ala Gln Arg Val Ser Arg Leu Thr Thr Ser Thr Thr Ile Glu Asn 
                 645                650                655
Ile Glu Ile Thr Ile Lys Ser Pro Asp Arg Thr Glu Glu Val Leu Ser 
             660                665                670
Pro Asp Gly Ser Pro Ser Lys Ser Pro Ser Lys Lys Lys Lys Lys Phe 
         675                680                685
Arg Thr Pro Ser Phe Leu Lys Lys Asn Lys Lys Lys Glu Lys Val Glu 
     690                695                700
Ala 
 705



<210> 8445
<211> 2920
<212> DNA
<213> Homo sapiens
<308> D67031
<400> 8445

tctggttcg  cccacctct  aaggttcca  aatcgatag  gaattcgtg  agtaggttt  60
tgtgcagca  tgcagaatc  acacctaga  aacagaaga  acagacacg  acgtctact  120
cccttgtta  aaggaagct  tggatcttc  gtggataac  agagtaatc  acagactta  180
aacatgagc  cagatgcca  ccaaggcgt  attaccact  ctcctcctc  cagcatgcc  240
cacaaagag  gatattttg  ccgcatcaa  gaaaatgac  cagaataca  tagggagag  300
aacatgtct  ctgatctac  acaagactc  agcatgatg  agcagagga  acgagttac  360
cggatcctg  aaagtcctg  ctttcggga  gacttggaa  gccttattc  agaacagat  420
aagaaaggc  acaacccaa  tggattact  gcattacag  agattgcag  ttacatcat  480
gccaattct  tctcgggtt  ttcttcacc  cctctcagt  ttggcatgg  cacacctat  540
aatgacctt  ctggtgcag  tacatcctc  tatgtgaag  gagaaaaac  tactcgctg  600
aaacttgcc  gcctgtaca  acttgtaga  ttgtttgga  gggcacacc  ggcaaatac  660
tatatctca  taagaataa  taaggagca  gaccacatt  taataattc  cagaggcct  720
tctttttct  aagctacag  ctccaattt  gtgaaagtc  atataatag  agaagtggt  780
gaccaggga  gtaccaatt  gaaaattga  catacagga  tcagtcccc  tgctgcaat  840
tattcaaca  gtcctgatg  taagtgtgt  atacacatc  atacccttg  aacagcagc  900
gtatcctcc  tgaaatgtg  gatccttcc  atttctcaa  agtctcttc  tctgggaga  960
gttgcctat  atgactacc  agggtcact  gaagaacag  aggagagaa  tcaactgca  1020
aaggttctg  gaccaagtt  taaagtgct  gtactcagg  atcatggtg  ggttgcact  1080
ggagaaaca  tagaggagg  ttttcatta  atttttaat  tgcaactag  ctgtgagat  1140
caggtgcag  ccctagcag  tgcaggtgg  gtagacaat  tccatgtac  ggactttca  1200
aagtataaa  ctttcactt  cactgtagc  gcgtctggt  gaggaggtg  gaatatggg  1260
tcccatcaa  aatggaagg  tggcgaaat  gagtttgaa  ggcttatga  gactctgga  1320
aacttgggg  atagaacag  ctatgctta  aggcatcct  tcattcgag  gaagcctag  1380
cacaagagt  atgtggaaa  cccagcaac  gtgactgct  tttcctttg  agacgatac  1440
gtgctactc  ctcctctca  atacatggc  cagaggcaa  agcgtgaaa  aacaagatg  1500
ctgaactca  caaatactt  catgaaagt  aatgtgcct  aggagtctc  gaacggaga  1560
accagtccc  gaaccaaaa  cacgtggat  aaagcagaa  actcatcta  agttagtgg  1620
ggaacacct  tcaaaattg  agatccaaa  cagtttgtt  ctttaaaca  aaacccgaa  1680
gaggtacta  aaaagagaa  taagattcg  gaacaaaat  gatatgact  gaaaacagc  1740
ggaccacaa  ctcagttgc  tgctggaat  gttgtggat  agccacctt  tactatgca  1800
tttgaagat  atgatcatg  cccaccagc  cctcctaac  catttagtc  tctcacaga  1860
ggagaactt  aagagtata  gaggacaat  gaacgtaaa  aacaaggcc  agaagaaaa  1920
catgagctg  tttccaaga  cttcatctc  atggaagtg  ctgtcatgg  agtaaatgg  1980
aaggatgat  tgcatgatg  tgaagatga  cttgctaag  gagtgagta  gttaagcac  2040
agtacaacc  tagaaaaca  cgagattac  attaagtct  cagagaaaa  cgaagaagt  2100
ctgtcacct  aaggctccc  ttcaaaatc  ccatccaag  aaaagaaga  attccgcac  2160
ccttctttt  tgaaaaaga  caaaaaaaa  gagaaagtt  aggcctaaa  aaagtcttt  2220
tataattat  attataaca  tgtgacatt  cacatctaa  taccacatt  aagttgatc  2280
ttaatatgc  atggtagat  agattgggg  atgtagcaa  ctggacttt  agaactgga  2340
agaggtttt  caaaagaaa  actttcaga  tcatctctc  ttttatatg  ccagaaatg  2400
ctttgaatt  taagcaatt  ctagtttta  ttagctctg  cctcatgaa  tattattat  2460
attcaccat  aacagctat  tgtctgaat  acttcaggc  ttctccata  tatctgtta  2520
aaagaaatt  ccagtgagc  agtgagaat  tttatttct  aatacctgc  tcacttgat  2580
atcatatta  aatttttta  catgattat  gactatatt  ttggagtcc  attgtttca  2640
tgggcatta  cagaatgct  taaaaactt  taagacaag  atctatagc  ttagtatac  2700
ctggcacat  attttttaa  aagttttaa  aaaagattc  tttggaatt  tattcacag  2760
ataaaattt  ctcacctga  gtaactttg  ttgccaaaa  agttgtttt  ataaactat  2820
atttttgaa  acttccttt  ttattagtt  agaaagccc  ttatttttc  acaaagggg  2880
ttttgtaca  ataacatgg  ttatttagt  taactctggc  2920



<210> 8446
<211> 706
<212> PRT
<213> Homo sapiens
<308> Q9UEY8
<400> 8446

Met Ser Ser Asp Ala Ser Gln Gly Val Ile Thr Thr Pro Pro Pro Pro 
  1               5                  10                  15
Ser Met Pro His Lys Glu Arg Tyr Phe Asp Arg Ile Asn Glu Asn Asp 
             20                  25                  30
Pro Glu Tyr Ile Arg Glu Arg Asn Met Ser Pro Asp Leu Arg Gln Asp 
         35                  40                  45
Phe Asn Met Met Glu Gln Arg Lys Arg Val Thr Gln Ile Leu Gln Ser 
     50                  55                  60
Pro Ala Phe Arg Glu Asp Leu Glu Cys Leu Ile Gln Glu Gln Met Lys 
 65                  70                  75                  80
Lys Gly His Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp 
                 85                  90                  95
Tyr Ile Met Ala Asn Ser Phe Ser Gly Phe Ser Ser Pro Pro Leu Ser 
             100                105                110
Leu Gly Met Val Thr Pro Ile Asn Asp Leu Pro Gly Ala Asp Thr Ser 
         115                120                125
Ser Tyr Val Lys Gly Glu Lys Leu Thr Arg Cys Lys Leu Ala Ser Leu 
     130                135                140
Tyr Arg Leu Val Asp Leu Phe Gly Trp Ala His Leu Ala Asn Thr Tyr 
 145                150                155                160
Ile Ser Val Arg Ile Ser Lys Glu Gln Asp His Ile Ile Ile Ile Pro 
                 165                170                175
Arg Gly Leu Ser Phe Ser Glu Ala Thr Ala Ser Asn Leu Val Lys Val 
             180                185                190
Asn Ile Ile Gly Glu Val Val Asp Gln Gly Ser Thr Asn Leu Lys Ile 
         195                200                205
Asp His Thr Gly Phe Ser Pro His Ala Ala Ile Tyr Ser Thr Arg Pro 
     210                215                220
Asp Val Lys Cys Val Ile His Ile His Thr Leu Ala Thr Ala Ala Val 
 225                230                235                240
Ser Ser Met Lys Cys Gly Ile Leu Pro Ile Ser Gln Glu Ser Leu Leu 
                 245                250                255
Leu Gly Asp Val Ala Tyr Tyr Asp Tyr Gln Gly Ser Leu Glu Glu Gln 
             260                265                270
Glu Glu Arg Ile Gln Leu Gln Lys Val Leu Gly Pro Ser Cys Lys Val 
         275                280                285
Leu Val Leu Arg Asn His Gly Val Val Ala Leu Gly Glu Thr Leu Glu 
     290                295                300
Glu Ala Phe His Tyr Ile Phe Asn Val Gln Leu Ala Cys Glu Ile Gln 
 305                310                315                320
Val Gln Ala Leu Ala Gly Ala Gly Gly Val Asp Asn Leu His Val Leu 
                 325                330                335
Asp Phe Gln Lys Tyr Lys Ala Phe Thr Tyr Thr Val Ala Ala Ser Gly 
             340                345                350
Gly Gly Gly Val Asn Met Gly Ser His Gln Lys Trp Lys Val Gly Glu 
         355                360                365
Ile Glu Phe Glu Gly Leu Met Arg Thr Leu Asp Asn Leu Gly Tyr Arg 
     370                375                380
Thr Gly Tyr Ala Tyr Arg His Pro Leu Ile Arg Glu Lys Pro Arg His 
 385                390                395                400
Lys Ser Asp Val Glu Ile Pro Ala Thr Val Thr Ala Phe Ser Phe Glu 
                 405                410                415
Asp Asp Thr Val Pro Leu Ser Pro Leu Lys Tyr Met Ala Gln Arg Gln 
             420                425                430
Gln Arg Glu Lys Thr Arg Trp Leu Asn Ser Pro Asn Thr Tyr Met Lys 
         435                440                445
Val Asn Val Pro Glu Glu Ser Arg Asn Gly Glu Thr Ser Pro Arg Thr 
     450                455                460
Lys Ile Thr Trp Met Lys Ala Glu Asp Ser Ser Lys Val Ser Gly Gly 
 465                470                475                480
Thr Pro Ile Lys Ile Glu Asp Pro Asn Gln Phe Val Pro Leu Asn Thr 
                 485                490                495
Asn Pro Asn Glu Val Leu Glu Lys Arg Asn Lys Ile Arg Glu Gln Asn 
             500                505                510
Arg Tyr Asp Leu Lys Thr Ala Gly Pro Gln Ser Gln Leu Leu Ala Gly 
         515                520                525
Ile Val Val Asp Lys Pro Pro Ser Thr Met Gln Phe Glu Asp Asp Asp 
     530                535                540
His Gly Pro Pro Ala Pro Pro Asn Pro Phe Ser His Leu Thr Glu Gly 
 545                550                555                560
Glu Leu Glu Glu Tyr Lys Arg Thr Ile Glu Arg Lys Gln Gln Gly Leu 
                 565                570                575
Glu Asp Ala Glu Gln Glu Leu Leu Ser Asp Asp Ala Ser Ser Val Ser 
             580                585                590
Gln Ile Gln Ser Gln Thr Gln Ser Pro Gln Asn Val Pro Glu Lys Leu 
         595                600                605
Glu Glu Asn His Glu Leu Phe Ser Lys Ser Phe Ile Ser Met Glu Val 
     610                615                620
Pro Val Met Val Val Asn Gly Lys Asp Asp Met His Asp Val Glu Asp 
 625                630                635                640
Glu Leu Ala Lys Arg Val Ser Arg Leu Ser Thr Ser Thr Thr Ile Glu 
                 645                650                655
Asn Ile Glu Ile Thr Ile Lys Ser Pro Glu Lys Ile Glu Glu Val Leu 
             660                665                670
Ser Pro Glu Gly Ser Pro Ser Lys Ser Pro Ser Lys Lys Lys Lys Lys 
         675                680                685
Phe Arg Thr Pro Ser Phe Leu Lys Lys Asn Lys Lys Lys Glu Lys Val 
     690                695                700
Glu Ala 
 705



<210> 8447
<211> 2246
<212> DNA
<213> Rattus norvegicus
<308> U35775
<400> 8447

ggcaggagt  ggatgtaga  cgctcctga  ttcaattcc  agcaaccac  cctagccgg  60
aagacggac  cgcgtcggc  cccctgcac  caaagcagc  ttggatcgc  tgcagggca  120
gaagactgg  agcatgagt  cagacagca  ccaagcggt  atcaccacc  ctcctcctc  180
cagcatgcc  cacaaagag  ggtattttg  ccgaatcaa  gaaagtgat  cagaatacc  240
ccgagagag  aacatgtct  ctgatctac  ggaggactt  aatatgatg  agcagagga  300
gcgagtcac  cagatcctg  agagtcctg  ctttcggga  gacctagag  gcctcaccc  360
agaacagat  aagaaaggc  acgacccga  cggattgct  gcgttacag  agatcgccg  420
ctacatcat  gccaactcc  tcaccggtt  ttcttcacc  cccctgagt  ttggcatgg  480
cactcctat  aatgacctt  ctggtgcag  cacatcctc  tatgtgaag  gagagaagc  540
cactcgttg  gaactcgcc  gcctgtaca  actcgcaga  ctgtttggg  gggcacatc  600
ggcaaatac  tacatctcg  tacgagtaa  taaggagca  gaccacatc  taatcatcc  660
cagaggcct  cctttctct  aagccacag  ctctgctct  gtgaaggtc  acataatag  720
agaagtggt  gaccagggg  gtactaatt  gaaaattga  cattcagga  tcagtcccc  780
tgctgcaat  tattcaacc  gtcccgatg  gaagtgtgt  atacacatc  acaccctcg  840
tacagcagc  gtgtcttcc  tgaagtgtg  gatccttcc  atttcccaa  agtctctca  900
cctgggaga  gtagcctat  atgactacc  ggggtcgct  gatgaggag  aggaaagaa  960
cgaacttca  aaagttctg  gtccaagct  taaggtgct  gtcctcagg  accatggcg  1020
ggtagctct  ggagaaaca  ttgaggagg  tttccacta  atcttcaat  tacagatgg  1080
ctgtgagat  caggtgcag  ctgtagcag  ggcaggggg  gtggacaat  ttctcatac  1140
ggatcttca  aaatacaaa  ctttcaccc  cggtgttgc  atgactgga  gaggcggtg  1200
gaatatggg  tcccatcag  agtggaaag  tggcgagat  gagtttgaa  ggctcatga  1260
aaccctgga  aacttgggc  acagaacag  ctacgcata  aggcatcct  tagttcgag  1320
gaagcctcg  cacaagagt  acgtggaga  cccagcaac  gtgactgca  tctcctttg  1380
agatgatag  gtgccactc  ctcccctca  gtacatggc  cagagacag  agcgtgaaa  1440
aacaagatg  ctgaattct  caaatacat  catgaaagt  aatgtgccg  aggagtccc  1500
gaacgggga  actagtccc  ggaccaaaa  aacgtggat  aaagcagag  acccctcta  1560
agttagtag  ggaacacct  tcaaaattg  agatcccaa  cagtttgtt  ctctaaaca  1620
gaacccgac  gaggtgctg  agaagagaa  taagattcg  gaacagaat  gctatgacc  1680
gaagacagc  gggccacag  ctcagctgc  ggcggggat  gttgtggac  aaccgcctt  1740
taccatgcg  tttgaagac  atgatcagg  cccaccagc  cctcctaac  cattcagtc  1800
tctcatgga  ggagaactt  aagaatata  gaagacaat  gagagacag  agcaaggcc  1860
ggacgaaaa  cacgagctg  tttccaaga  cttcacctc  gtggatgtg  ctgtcattg  1920
gaatggcaa  gacgagatg  acgatgttg  agacgagct  gctcagcgc  tcagcaggc  1980
cacgacgag  accaccata  agaacatcg  gatcaccat  aagtcccca  acagaactg  2040
agaggtcct  tcacccgat  gctcgcctt  aaagtcacc  tccaagaaa  agaagaaat  2100
ccgcacacc  tcttttctc  aaaagaaca  aaaaaaagg  gaaagttga  gcctaagta  2160
tctttctgt  atttgtaca  tacattgtg  cattgcaca  ttaaatacc  tattttagt  2220
aatcgttaa  atacggtgg  agagcc  2246



<210> 8448
<211> 705
<212> PRT
<213> Rattus norvegicus
<308> Q62847
<400> 8448

Met Ser Ser Asp Ser Ser Gln Ala Val Ile Thr Thr Pro Pro Pro Pro 
  1               5                  10                  15
Ser Met Pro His Lys Glu Arg Tyr Phe Asp Arg Ile Asn Glu Ser Asp 
             20                  25                  30
Pro Glu Tyr Leu Arg Glu Arg Asn Met Ser Pro Asp Leu Arg Glu Asp 
         35                  40                  45
Phe Asn Met Met Glu Gln Arg Lys Arg Val Thr Gln Ile Leu Gln Ser 
     50                  55                  60
Pro Ala Phe Arg Glu Asp Leu Glu Cys Leu Thr Gln Glu Gln Met Lys 
 65                  70                  75                  80
Lys Gly His Asp Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp 
                 85                  90                  95
Tyr Ile Met Ala Asn Ser Phe Thr Gly Phe Ser Ser Pro Pro Leu Ser 
             100                105                110
Leu Gly Met Val Thr Pro Ile Asn Asp Leu Pro Gly Ala Asp Thr Ser 
         115                120                125
Ser Tyr Val Lys Gly Glu Lys Leu Thr Arg Cys Glu Leu Ala Ser Leu 
     130                135                140
Tyr Arg Leu Ala Asp Leu Phe Gly Trp Ala His Leu Ala Asn Thr Tyr 
 145                150                155                160
Ile Ser Val Arg Val Ser Lys Glu Gln Asp His Ile Ile Ile Ile Pro 
                 165                170                175
Arg Gly Leu Pro Phe Ser Glu Ala Thr Ala Ser Ala Leu Val Lys Val 
             180                185                190
Asn Ile Ile Gly Glu Val Val Asp Gln Gly Ser Thr Asn Leu Lys Ile 
         195                200                205
Asp His Ser Gly Phe Ser Pro His Ala Ala Ile Tyr Ser Thr Arg Pro 
     210                215                220
Asp Val Lys Cys Val Ile His Ile His Thr Leu Ala Thr Ala Ala Val 
 225                230                235                240
Ser Ser Met Lys Cys Gly Ile Leu Pro Ile Ser Gln Glu Ser Leu Ile 
                 245                250                255
Leu Gly Asp Val Ala Tyr Tyr Asp Tyr Gln Gly Ser Leu Asp Glu Glu 
             260                265                270
Glu Glu Arg Ile Glu Leu Gln Lys Val Leu Gly Pro Ser Cys Lys Val 
         275                280                285
Leu Val Leu Arg Asn His Gly Val Val Ala Leu Gly Glu Thr Leu Glu 
     290                295                300
Glu Ala Phe His Tyr Ile Phe Asn Val Gln Met Ala Cys Glu Ile Gln 
 305                310                315                320
Val Gln Ala Val Ala Gly Ala Gly Gly Val Asp Asn Leu Leu Ile Leu 
                 325                330                335
Asp Leu Gln Lys Tyr Lys Ala Phe Thr His Gly Val Ala Met Thr Gly 
             340                345                350
Gly Gly Gly Val Asn Met Gly Ser His Gln Lys Trp Lys Val Gly Glu 
         355                360                365
Ile Glu Phe Glu Gly Leu Met Arg Thr Leu Asp Asn Leu Gly Tyr Arg 
     370                375                380
Thr Gly Tyr Ala Tyr Arg His Pro Leu Val Arg Glu Lys Pro Arg His 
 385                390                395                400
Lys Ser Asp Val Glu Ile Pro Ala Thr Val Thr Ala Phe Ser Phe Glu 
                 405                410                415
Asp Asp Ser Val Pro Leu Ser Pro Leu Lys Tyr Met Ala Gln Arg Gln 
             420                425                430
Gln Arg Glu Lys Thr Arg Trp Leu Asn Ser Pro Asn Thr Tyr Met Lys 
         435                440                445
Val Asn Val Pro Glu Glu Ser Arg Asn Gly Glu Thr Ser Pro Arg Thr 
     450                455                460
Lys Ile Thr Trp Met Lys Ala Glu Asp Pro Ser Lys Val Ser Ser Gly 
 465                470                475                480
Thr Pro Ile Lys Ile Glu Asp Pro Asn Gln Phe Val Pro Leu Asn Thr 
                 485                490                495
Asn Pro Thr Glu Val Leu Glu Lys Arg Asn Lys Ile Arg Glu Gln Asn 
             500                505                510
Arg Tyr Asp Leu Lys Thr Ala Gly Pro Gln Ser Gln Leu Leu Ala Gly 
         515                520                525
Ile Val Val Asp Lys Pro Pro Ser Thr Met Arg Phe Glu Asp Asp Asp 
     530                535                540
Gln Gly Pro Pro Ala Pro Pro Asn Pro Phe Ser His Leu Met Glu Gly 
 545                550                555                560
Glu Leu Glu Glu Tyr Thr Lys Thr Ile Glu Arg Gln Gln Gln Gly Leu 
                 565                570                575
Asp Asp Ala Glu Gln Glu Ser Leu Ser Asp Asp Ala Ala Ser Val Ser 
             580                585                590
Gln Ile Gln Ser Gln Thr Gln Ser Pro Gln Ser Val Pro Glu Arg Leu 
         595                600                605
Glu Glu Asn His Glu Leu Phe Ser Lys Ser Phe Thr Ser Val Asp Val 
     610                615                620
Pro Val Ile Val Asn Gly Lys Asp Glu Met His Asp Val Glu Asp Glu 
 625                630                635                640
Leu Ala Gln Arg Val Ser Arg Leu Thr Thr Ser Thr Thr Ile Glu Asn 
                 645                650                655
Ile Glu Ile Thr Ile Lys Ser Pro Asp Arg Thr Glu Glu Val Leu Ser 
             660                665                670
Pro Asp Gly Ser Pro Ser Lys Ser Pro Ser Lys Lys Lys Lys Lys Phe 
         675                680                685
Arg Thr Pro Ser Phe Leu Lys Lys Asn Lys Lys Lys Glu Lys Val Glu 
     690                695                700
Ala 
 705



<210> 8449
<211> 2920
<212> DNA
<213> Homo sapiens
<308> D67031
<400> 8449

tctggttcg  cccacctct  aaggttcca  aatcgatag  gaattcgtg  agtaggttt  60
tgtgcagca  tgcagaatc  acacctaga  aacagaaga  acagacacg  acgtctact  120
cccttgtta  aaggaagct  tggatcttc  gtggataac  agagtaatc  acagactta  180
aacatgagc  cagatgcca  ccaaggcgt  attaccact  ctcctcctc  cagcatgcc  240
cacaaagag  gatattttg  ccgcatcaa  gaaaatgac  cagaataca  tagggagag  300
aacatgtct  ctgatctac  acaagactc  agcatgatg  agcagagga  acgagttac  360
cggatcctg  aaagtcctg  ctttcggga  gacttggaa  gccttattc  agaacagat  420
aagaaaggc  acaacccaa  tggattact  gcattacag  agattgcag  ttacatcat  480
gccaattct  tctcgggtt  ttcttcacc  cctctcagt  ttggcatgg  cacacctat  540
aatgacctt  ctggtgcag  tacatcctc  tatgtgaag  gagaaaaac  tactcgctg  600
aaacttgcc  gcctgtaca  acttgtaga  ttgtttgga  gggcacacc  ggcaaatac  660
tatatctca  taagaataa  taaggagca  gaccacatt  taataattc  cagaggcct  720
tctttttct  aagctacag  ctccaattt  gtgaaagtc  atataatag  agaagtggt  780
gaccaggga  gtaccaatt  gaaaattga  catacagga  tcagtcccc  tgctgcaat  840
tattcaaca  gtcctgatg  taagtgtgt  atacacatc  atacccttg  aacagcagc  900
gtatcctcc  tgaaatgtg  gatccttcc  atttctcaa  agtctcttc  tctgggaga  960
gttgcctat  atgactacc  agggtcact  gaagaacag  aggagagaa  tcaactgca  1020
aaggttctg  gaccaagtt  taaagtgct  gtactcagg  atcatggtg  ggttgcact  1080
ggagaaaca  tagaggagg  ttttcatta  atttttaat  tgcaactag  ctgtgagat  1140
caggtgcag  ccctagcag  tgcaggtgg  gtagacaat  tccatgtac  ggactttca  1200
aagtataaa  ctttcactt  cactgtagc  gcgtctggt  gaggaggtg  gaatatggg  1260
tcccatcaa  aatggaagg  tggcgaaat  gagtttgaa  ggcttatga  gactctgga  1320
aacttgggg  atagaacag  ctatgctta  aggcatcct  tcattcgag  gaagcctag  1380
cacaagagt  atgtggaaa  cccagcaac  gtgactgct  tttcctttg  agacgatac  1440
gtgctactc  ctcctctca  atacatggc  cagaggcaa  agcgtgaaa  aacaagatg  1500
ctgaactca  caaatactt  catgaaagt  aatgtgcct  aggagtctc  gaacggaga  1560
accagtccc  gaaccaaaa  cacgtggat  aaagcagaa  actcatcta  agttagtgg  1620
ggaacacct  tcaaaattg  agatccaaa  cagtttgtt  ctttaaaca  aaacccgaa  1680
gaggtacta  aaaagagaa  taagattcg  gaacaaaat  gatatgact  gaaaacagc  1740
ggaccacaa  ctcagttgc  tgctggaat  gttgtggat  agccacctt  tactatgca  1800
tttgaagat  atgatcatg  cccaccagc  cctcctaac  catttagtc  tctcacaga  1860
ggagaactt  aagagtata  gaggacaat  gaacgtaaa  aacaaggcc  agaagaaaa  1920
catgagctg  tttccaaga  cttcatctc  atggaagtg  ctgtcatgg  agtaaatgg  1980
aaggatgat  tgcatgatg  tgaagatga  cttgctaag  gagtgagta  gttaagcac  2040
agtacaacc  tagaaaaca  cgagattac  attaagtct  cagagaaaa  cgaagaagt  2100
ctgtcacct  aaggctccc  ttcaaaatc  ccatccaag  aaaagaaga  attccgcac  2160
ccttctttt  tgaaaaaga  caaaaaaaa  gagaaagtt  aggcctaaa  aaagtcttt  2220
tataattat  attataaca  tgtgacatt  cacatctaa  taccacatt  aagttgatc  2280
ttaatatgc  atggtagat  agattgggg  atgtagcaa  ctggacttt  agaactgga  2340
agaggtttt  caaaagaaa  actttcaga  tcatctctc  ttttatatg  ccagaaatg  2400
ctttgaatt  taagcaatt  ctagtttta  ttagctctg  cctcatgaa  tattattat  2460
attcaccat  aacagctat  tgtctgaat  acttcaggc  ttctccata  tatctgtta  2520
aaagaaatt  ccagtgagc  agtgagaat  tttatttct  aatacctgc  tcacttgat  2580
atcatatta  aatttttta  catgattat  gactatatt  ttggagtcc  attgtttca  2640
tgggcatta  cagaatgct  taaaaactt  taagacaag  atctatagc  ttagtatac  2700
ctggcacat  attttttaa  aagttttaa  aaaagattc  tttggaatt  tattcacag  2760
ataaaattt  ctcacctga  gtaactttg  ttgccaaaa  agttgtttt  ataaactat  2820
atttttgaa  acttccttt  ttattagtt  agaaagccc  ttatttttc  acaaagggg  2880
ttttgtaca  ataacatgg  ttatttagt  taactctggc  2920



<210> 8450
<211> 706
<212> PRT
<213> Homo sapiens
<308> Q9UEY8
<400> 8450

Met Ser Ser Asp Ala Ser Gln Gly Val Ile Thr Thr Pro Pro Pro Pro 
  1               5                  10                  15
Ser Met Pro His Lys Glu Arg Tyr Phe Asp Arg Ile Asn Glu Asn Asp 
             20                  25                  30
Pro Glu Tyr Ile Arg Glu Arg Asn Met Ser Pro Asp Leu Arg Gln Asp 
         35                  40                  45
Phe Asn Met Met Glu Gln Arg Lys Arg Val Thr Gln Ile Leu Gln Ser 
     50                  55                  60
Pro Ala Phe Arg Glu Asp Leu Glu Cys Leu Ile Gln Glu Gln Met Lys 
 65                  70                  75                  80
Lys Gly His Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp 
                 85                  90                  95
Tyr Ile Met Ala Asn Ser Phe Ser Gly Phe Ser Ser Pro Pro Leu Ser 
             100                105                110
Leu Gly Met Val Thr Pro Ile Asn Asp Leu Pro Gly Ala Asp Thr Ser 
         115                120                125
Ser Tyr Val Lys Gly Glu Lys Leu Thr Arg Cys Lys Leu Ala Ser Leu 
     130                135                140
Tyr Arg Leu Val Asp Leu Phe Gly Trp Ala His Leu Ala Asn Thr Tyr 
 145                150                155                160
Ile Ser Val Arg Ile Ser Lys Glu Gln Asp His Ile Ile Ile Ile Pro 
                 165                170                175
Arg Gly Leu Ser Phe Ser Glu Ala Thr Ala Ser Asn Leu Val Lys Val 
             180                185                190
Asn Ile Ile Gly Glu Val Val Asp Gln Gly Ser Thr Asn Leu Lys Ile 
         195                200                205
Asp His Thr Gly Phe Ser Pro His Ala Ala Ile Tyr Ser Thr Arg Pro 
     210                215                220
Asp Val Lys Cys Val Ile His Ile His Thr Leu Ala Thr Ala Ala Val 
 225                230                235                240
Ser Ser Met Lys Cys Gly Ile Leu Pro Ile Ser Gln Glu Ser Leu Leu 
                 245                250                255
Leu Gly Asp Val Ala Tyr Tyr Asp Tyr Gln Gly Ser Leu Glu Glu Gln 
             260                265                270
Glu Glu Arg Ile Gln Leu Gln Lys Val Leu Gly Pro Ser Cys Lys Val 
         275                280                285
Leu Val Leu Arg Asn His Gly Val Val Ala Leu Gly Glu Thr Leu Glu 
     290                295                300
Glu Ala Phe His Tyr Ile Phe Asn Val Gln Leu Ala Cys Glu Ile Gln 
 305                310                315                320
Val Gln Ala Leu Ala Gly Ala Gly Gly Val Asp Asn Leu His Val Leu 
                 325                330                335
Asp Phe Gln Lys Tyr Lys Ala Phe Thr Tyr Thr Val Ala Ala Ser Gly 
             340                345                350
Gly Gly Gly Val Asn Met Gly Ser His Gln Lys Trp Lys Val Gly Glu 
         355                360                365
Ile Glu Phe Glu Gly Leu Met Arg Thr Leu Asp Asn Leu Gly Tyr Arg 
     370                375                380
Thr Gly Tyr Ala Tyr Arg His Pro Leu Ile Arg Glu Lys Pro Arg His 
 385                390                395                400
Lys Ser Asp Val Glu Ile Pro Ala Thr Val Thr Ala Phe Ser Phe Glu 
                 405                410                415
Asp Asp Thr Val Pro Leu Ser Pro Leu Lys Tyr Met Ala Gln Arg Gln 
             420                425                430
Gln Arg Glu Lys Thr Arg Trp Leu Asn Ser Pro Asn Thr Tyr Met Lys 
         435                440                445
Val Asn Val Pro Glu Glu Ser Arg Asn Gly Glu Thr Ser Pro Arg Thr 
     450                455                460
Lys Ile Thr Trp Met Lys Ala Glu Asp Ser Ser Lys Val Ser Gly Gly 
 465                470                475                480
Thr Pro Ile Lys Ile Glu Asp Pro Asn Gln Phe Val Pro Leu Asn Thr 
                 485                490                495
Asn Pro Asn Glu Val Leu Glu Lys Arg Asn Lys Ile Arg Glu Gln Asn 
             500                505                510
Arg Tyr Asp Leu Lys Thr Ala Gly Pro Gln Ser Gln Leu Leu Ala Gly 
         515                520                525
Ile Val Val Asp Lys Pro Pro Ser Thr Met Gln Phe Glu Asp Asp Asp 
     530                535                540
His Gly Pro Pro Ala Pro Pro Asn Pro Phe Ser His Leu Thr Glu Gly 
 545                550                555                560
Glu Leu Glu Glu Tyr Lys Arg Thr Ile Glu Arg Lys Gln Gln Gly Leu 
                 565                570                575
Glu Asp Ala Glu Gln Glu Leu Leu Ser Asp Asp Ala Ser Ser Val Ser 
             580                585                590
Gln Ile Gln Ser Gln Thr Gln Ser Pro Gln Asn Val Pro Glu Lys Leu 
         595                600                605
Glu Glu Asn His Glu Leu Phe Ser Lys Ser Phe Ile Ser Met Glu Val 
     610                615                620
Pro Val Met Val Val Asn Gly Lys Asp Asp Met His Asp Val Glu Asp 
 625                630                635                640
Glu Leu Ala Lys Arg Val Ser Arg Leu Ser Thr Ser Thr Thr Ile Glu 
                 645                650                655
Asn Ile Glu Ile Thr Ile Lys Ser Pro Glu Lys Ile Glu Glu Val Leu 
             660                665                670
Ser Pro Glu Gly Ser Pro Ser Lys Ser Pro Ser Lys Lys Lys Lys Lys 
         675                680                685
Phe Arg Thr Pro Ser Phe Leu Lys Lys Asn Lys Lys Lys Glu Lys Val 
     690                695                700
Glu Ala 
 705



<210> 8451
<211> 1862
<212> DNA
<213> Rattus norvegicus
<308> U35776
<400> 8451

cggggatct  agtgcctag  ccagcttgg  acctgggcc  gacccgacc  cctcggggc  60
gcaggatcc  agtgtgcgg  ggtccagac  cccccgccc  gccccgccc  cggcctgtg  120
gccttgcgc  cttcagcat  gcggttgcg  ggatctacg  ggcctttca  cgctcaggt  180
ccgagcact  tcagacgca  actggtttt  cagagccca  ttggccggg  aagggcccc  240
gcccttcac  tcgaaagaa  attctgtcc  gaggtgccg  accatggcc  gcccaagaa  300
cagaaaagt  cttaaggaa  tccgggcac  ggacgagaa  aatgtttgc  ttgagtgtg  360
tgcgttcaa  cctcagtgg  tcagcgtga  ctatggcat  tggatctgc  tggaatgct  420
tgggagaca  cgtgggctt  gggtgcatc  cagcttcgt  cgctctgtg  caatggaca  480
gtggaagga  attgaactg  agaagatga  agctggtgg  aatgctaag  tccgagagt  540
cctggaggc  caggacgac  atgagccta  ctggtcact  caggacaag  atagcagca  600
agctgcagc  ctcttcagg  ataaggtgg  tactttggc  gaaggtaaa  aatggtctc  660
ggagtcatc  cctgcccag  actggaccc  acctcagcc  aagacgctg  agttcactg  720
ccaccgacc  gctggccag  cacagaatg  aactacctc  ggggacaag  cctttgagg  780
ttggctgaa  gatgatctg  gttcctatc  gggtgctca  gagaatcgc  atgtggggt  840
tgggaacac  gtgccacct  agaagagag  agatgactt  ctcaacagc  ccatgtcat  900
tctgtactc  ggctggagc  gttttacca  tggggcgag  aagtttgcg  ctgcagcaa  960
ggagggtgc  acaaaattt  gatctcaag  aagtcaaaa  gcttcggag  tgggccaca  1020
cctgaatga  aatgttctc  agcctgcac  ggagaaggt  aaagaggga  ggatttttg  1080
tgatgtgtc  agtggggtc  ctcagttgg  atccaaggt  cagggagtt  gcagtaagg  1140
atggcgtga  gtcacgacc  tcttttctg  gaaagctga  gacacttca  acagaccct  1200
agagggcca  agctaccag  acagcagtg  agacaactc  cagaacagc  ccatagacc  1260
gagcttctg  gagaccttc  ggagtgctg  gccccccaa  gccaagtcc  caagcagtg  1320
cagctggac  tgcgcagat  cctcaacgg  aaggaggag  tcggacagc  gggacattt  1380
gggctcagg  tctgcatcc  acaacaaga  cagcaatag  gatggttgg  agagctggg  1440
gggagccag  ggggaggga  gggcaaagg  taccaagaa  gcagctcca  ctacagccg  1500
cgacgaggg  tgggacaac  agaactggt  ggagccttg  tgcacccta  cccagccct  1560
ctgggagac  gctgtgttt  cactttacc  ttgttcctc  ttcatttga  ctcagtgtg  1620
agacagtgg  tcaggcagg  cttgagttg  tgctgcctg  ctggtgtgg  gtggctttc  1680
cttagacct  aggggacat  tcatccacc  gcctcttgg  tcctctgag  agccttcct  1740
gattctggg  tcttgggac  caggcactg  ctctgcagc  ctagcatag  ctgggactg  1800
agccctgtg  aatgtcagc  aagccagac  tctgctttc  ttgaaatgt  tttttaaac  1860
tg  1862



<210> 8452
<211> 415
<212> PRT
<213> Rattus norvegicus
<308> AAC52337
<400> 8452

Met Ala Ser Pro Arg Thr Arg Lys Val Leu Lys Glu Val Arg Ala Gln 
  1               5                  10                  15
Asp Glu Asn Asn Val Cys Phe Glu Cys Gly Ala Phe Asn Pro Gln Trp 
             20                  25                  30
Val Ser Val Thr Tyr Gly Ile Trp Ile Cys Leu Glu Cys Ser Gly Arg 
         35                  40                  45
His Arg Gly Leu Gly Val His Leu Ser Phe Val Arg Ser Val Thr Met 
     50                  55                  60
Asp Lys Trp Lys Asp Ile Glu Leu Glu Lys Met Lys Ala Gly Gly Asn 
 65                  70                  75                  80
Ala Lys Phe Arg Glu Phe Leu Glu Ala Gln Asp Asp Tyr Glu Pro Ser 
                 85                  90                  95
Trp Ser Leu Gln Asp Lys Tyr Ser Ser Arg Ala Ala Ala Leu Phe Arg 
             100                105                110
Asp Lys Val Ala Thr Leu Ala Glu Gly Lys Glu Trp Ser Leu Glu Ser 
         115                120                125
Ser Pro Ala Gln Asn Trp Thr Pro Pro Gln Pro Lys Thr Leu Gln Phe 
     130                135                140
Thr Ala His Arg Pro Ala Gly Gln Pro Gln Asn Val Thr Thr Ser Gly 
 145                150                155                160
Asp Lys Ala Phe Glu Asp Trp Leu Asn Asp Asp Leu Gly Ser Tyr Gln 
                 165                170                175
Gly Ala Gln Glu Asn Arg Tyr Val Gly Phe Gly Asn Thr Val Pro Pro 
             180                185                190
Gln Lys Arg Glu Asp Asp Phe Leu Asn Ser Ala Met Ser Ser Leu Tyr 
         195                200                205
Ser Gly Trp Ser Ser Phe Thr Thr Gly Ala Ser Lys Phe Ala Ser Ala 
     210                215                220
Ala Lys Glu Gly Ala Thr Lys Phe Gly Ser Gln Ala Ser Gln Lys Ala 
 225                230                235                240
Ser Glu Leu Gly His Ser Leu Asn Glu Asn Val Leu Lys Pro Ala Gln 
                 245                250                255
Glu Lys Val Lys Glu Gly Arg Ile Phe Asp Asp Val Ser Ser Gly Val 
             260                265                270
Ser Gln Leu Ala Ser Lys Val Gln Gly Val Gly Ser Lys Gly Trp Arg 
         275                280                285
Asp Val Thr Thr Phe Phe Ser Gly Lys Ala Glu Asp Thr Ser Asp Arg 
     290                295                300
Pro Leu Glu Gly His Ser Tyr Gln Asn Ser Ser Gly Asp Asn Ser Gln 
 305                310                315                320
Asn Ser Thr Ile Asp Gln Ser Phe Trp Glu Thr Phe Gly Ser Ala Glu 
                 325                330                335
Pro Pro Lys Ala Lys Ser Pro Ser Ser Asp Ser Trp Thr Cys Ala Asp 
             340                345                350
Ala Ser Thr Gly Arg Arg Ser Ser Asp Ser Trp Asp Ile Trp Gly Ser 
         355                360                365
Gly Ser Ala Ser Asn Asn Lys Asn Ser Asn Ser Asp Gly Trp Glu Ser 
     370                375                380
Trp Glu Gly Ala Ser Gly Glu Gly Arg Ala Lys Ala Thr Lys Lys Ala 
 385                390                395                400
Ala Pro Ser Thr Ala Ala Asp Glu Gly Trp Asp Asn Gln Asn Trp 
                 405                410                415



<210> 8453
<211> 3248
<212> DNA
<213> Homo sapiens
<308> NM_018209
<400> 8453

ggaagctgg  ggcggctgg  gggcgaccg  gcgcatcct  attgcagtg  ggcggccct  60
cctcggccc  ggcctgacc  cggcggccc  gcccgcccc  ccctccagc  tcatggcca  120
cccaagaac  aggaaggtt  ttaaagaag  cagggtgca  gatgagaac  acgtttgtt  180
tgagtgtgg  gcgttcaat  ctcagtggg  cagtgtgac  tacggcatc  ggatctgcc  240
ggagtgctc  gggagacac  gcgggcttg  ggttcacct  agctttgtg  gctctgtta  300
tatggacaa  tggaaggac  ttgagcttg  gaagatgaa  gctggtggg  atgctaagt  360
ccgagagtt  ctggagtct  aggaggatt  cgatccttg  tggtccttg  aggagaagt  420
caacagcag  gccgcggcc  tctttaggg  taaggtggt  gctctggcc  aaggcagag  480
gtggtctct  gagtcatca  ctgcccaga  ctggacccc  cctcagccc  ggacgctgc  540
gtccatggt  caccgagtc  ctggccagc  gcagagtgt  accgcctcc  cggacaagg  600
ttttgagga  tggctgaat  atgacctcg  ctcctatca  ggggcccag  ggaatcgct  660
cgtggggtt  gggaacacg  caccgcctc  gaagaaaga  gatgacttc  tcaacaacg  720
catgtcctc  ctgtactcg  gctggagca  cttcaccac  ggagccagc  ggtttgcct  780
ggcagccaa  gagggcgct  caaagtttg  atcccaagc  agtcagaag  cgtccgagc  840
gggccacag  ctgaacgag  acgtcctca  gcctgcgca  gagaaggtg  aggagggaa  900
gatttttga  gatgtctcc  gtggggtct  tcagttggc  tccaaggtc  agggagtcg  960
tagtaaggg  tggcgggac  tcaccacct  tttttcggg  aaagcagag  gccccttgg  1020
cagcccctc  gagggccac  gttatcaga  cagcggtct  gaccacttc  aaaacagca  1080
catagacca  agcttctgg  agacctttg  aagtgctga  cccaccaag  cccgcaagt  1140
cccgagcag  gacagctgg  cgtgcgcgg  cacctccac  gagaggagg  gctcggaca  1200
ctgggaggt  tggggctcg  cctccacca  caggaacag  aacagcgac  gcggggagg  1260
cggggaggg  accaagaag  cagtgccgc  ggccgtgcc  actgatgat  gctgggaca  1320
ccagaactg  tagggccca  tgcgccccc  tccccagcg  ccccgggcg  cttcgtgtt  1380
gcactctgc  ctcgtcgtt  ctcctcctt  catttgacc  aagaatcag  aactgcagt  1440
tgaggacag  gtctcggga  gcaggaccc  agggagacc  gggtgtgcg  cgcctgcgc  1500
tggggagtc  tcggtgcgt  ggggcggct  gctgtccag  ctgtgtggg  gccgtcccg  1560
cccacactc  cctgggcat  cttggactc  aggccgggg  tctgcgtgg  ttgctggga  1620
gtgggctgc  gcacagagg  ctgtgactg  gttccagcg  ccagttcac  acgcagtat  1680
tctggggcc  gggaccagc  acgtgccga  ctgtcagcg  cgtgaggtg  cccttctcg  1740
tgagatatt  aactttggt  ttgctctag  tctttcttt  tgaagagag  gactggagt  1800
gtaaagatg  aaatgctgg  aatgatact  gcgctcacg  tgccatccg  ccaccctcg  1860
ctcccgagt  cacgcctgc  tgggcctgt  ctgtcagac  cgcgtcggt  gtaaccctc  1920
gtggctccc  tgcatcagc  ccgtcccac  accaagttc  ccaggttca  cagacacgg  1980
ctccacaat  gccacaccc  cacctgagc  gtcctcagt  ctggaactt  accatcctg  2040
aacaccctg  aagaaaaag  agcgcaggg  gggccctcg  ccctgatgc  ggagggtgc  2100
atagcggac  tggccaggc  ggaggggcc  ggttcagga  ctgagcagg  gatgcctgt  2160
cgtggtgcc  gggtctagg  aagctccag  cccaggatg  ggctgccct  cacaccggt  2220
cccgccaca  gccaaccct  acctccccg  ggactggat  atgtgctgc  acgtgtgac  2280
cgtctccct  gtctgccct  tgtgaccct  agtcttggc  agccatgca  gcgcccgaa  2340
ctcgtgcag  ttgtacgtg  ggtgctctc  tccctgcca  catgctcat  actctggcc  2400
tggccatgc  ccctggtca  cccacttcc  ggtcgccgt  tgcagcact  ctggagcag  2460
ctgggccct  cagcccctg  gctcgtccc  ccctaggga  tcagtcact  gcagaacag  2520
atgggaccg  gatttcagc  agccctcct  gcgcccggt  ctccctgtg  gcaccagcc  2580
tcttggtag  tggtgtgga  ggccggtgt  cttggctgc  acggaggga  ttgatcacc  2640
aagcagcca  ctgctgtag  tggacctga  gtcagaggc  gggcatcag  ggctcaagg  2700
gctgagaag  caccgggaa  gcagccagc  caaagggcc  aggaagcca  cccccgaga  2760
ctgagcgtg  gggtctttg  gtgtctttc  ccaagctga  acgtgggcg  ccgcgtggt  2820
tctcccgag  gctgcttgg  ccctggtgg  ctgagtgct  cgaggaggg  tggactcca  2880
cttggacag  gggatgtgg  gttccacat  tgcctgttt  cacgccagc  ccttgactt  2940
gcagcatgg  gccaaggtc  gtccccgcc  aggagggtg  cttcctcgg  ggtaggggg  3000
cggcccact  tgccccagg  agtcccttt  gatgggaag  gcagtcagc  gcgtggagg  3060
gtctgggcc  ccttcagaa  gtggatgtg  tggccgaga  cccgtccac  gagggtgat  3120
gcctttccc  tctgcaggt  cgggcaggt  ggcctggga  cggtgctgg  gcctctcct  3180
gctgtgtgt  agggcccag  tggaaggcg  ggacctgac  gcattccaa  aaagcatac  3240
ggaacatg  3248



<210> 8454
<211> 406
<212> PRT
<213> Homo sapiens
<308> NP_060679
<400> 8454

Met Ala Ser Pro Arg Thr Arg Lys Val Leu Lys Glu Val Arg Val Gln 
  1               5                  10                  15
Asp Glu Asn Asn Val Cys Phe Glu Cys Gly Ala Phe Asn Pro Gln Trp 
             20                  25                  30
Val Ser Val Thr Tyr Gly Ile Trp Ile Cys Leu Glu Cys Ser Gly Arg 
         35                  40                  45
His Arg Gly Leu Gly Val His Leu Ser Phe Val Arg Ser Val Thr Met 
     50                  55                  60
Asp Lys Trp Lys Asp Ile Glu Leu Glu Lys Met Lys Ala Gly Gly Asn 
 65                  70                  75                  80
Ala Lys Phe Arg Glu Phe Leu Glu Ser Gln Glu Asp Tyr Asp Pro Cys 
                 85                  90                  95
Trp Ser Leu Gln Glu Lys Tyr Asn Ser Arg Ala Ala Ala Leu Phe Arg 
             100                105                110
Asp Lys Val Val Ala Leu Ala Glu Gly Arg Glu Trp Ser Leu Glu Ser 
         115                120                125
Ser Pro Ala Gln Asn Trp Thr Pro Pro Gln Pro Arg Thr Leu Pro Ser 
     130                135                140
Met Val His Arg Val Ser Gly Gln Pro Gln Ser Val Thr Ala Ser Ser 
 145                150                155                160
Asp Lys Ala Phe Glu Asp Trp Leu Asn Asp Asp Leu Gly Ser Tyr Gln 
                 165                170                175
Gly Ala Gln Gly Asn Arg Tyr Val Gly Phe Gly Asn Thr Pro Pro Pro 
             180                185                190
Gln Lys Lys Glu Asp Asp Phe Leu Asn Asn Ala Met Ser Ser Leu Tyr 
         195                200                205
Ser Gly Trp Ser Ser Phe Thr Thr Gly Ala Ser Arg Phe Ala Ser Ala 
     210                215                220
Ala Lys Glu Gly Ala Thr Lys Phe Gly Ser Gln Ala Ser Gln Lys Ala 
 225                230                235                240
Ser Glu Leu Gly His Ser Leu Asn Glu Asn Val Leu Lys Pro Ala Gln 
                 245                250                255
Glu Lys Val Lys Glu Gly Lys Ile Phe Asp Asp Val Ser Ser Gly Val 
             260                265                270
Ser Gln Leu Ala Ser Lys Val Gln Gly Val Gly Ser Lys Gly Trp Arg 
         275                280                285
Asp Val Thr Thr Phe Phe Ser Gly Lys Ala Glu Gly Pro Leu Asp Ser 
     290                295                300
Pro Ser Glu Gly His Ser Tyr Gln Asn Ser Gly Leu Asp His Phe Gln 
 305                310                315                320
Asn Ser Asn Ile Asp Gln Ser Phe Trp Glu Thr Phe Gly Ser Ala Glu 
                 325                330                335
Pro Thr Lys Thr Arg Lys Ser Pro Ser Ser Asp Ser Trp Thr Cys Ala 
             340                345                350
Asp Thr Ser Thr Glu Arg Arg Ser Ser Asp Ser Trp Glu Val Trp Gly 
         355                360                365
Ser Ala Ser Thr Asn Arg Asn Ser Asn Ser Asp Gly Gly Glu Gly Gly 
     370                375                380
Glu Gly Thr Lys Lys Ala Val Pro Pro Ala Val Pro Thr Asp Asp Gly 
 385                390                395                400
Trp Asp Asn Gln Asn Trp 
                 405



<210> 8455
<211> 1838
<212> DNA
<213> Rattus norvegicus
<308> U35890
<400> 8455

atatgactg  gatttctga  gaaaccaga  tggaataat  ttcatsata  ttgtatatt  60
atatatata  attttaaaa  tttacattt  acttaaagt  ccatgagaa  atttgcata  120
tgcaaggtg  ttctagcca  ctccttggt  tgggtactc  tggatatgt  cctgctgct  180
tacttcagt  aatgcaaca  atgtgaaga  aagaaggag  gagggcttc  tgctgggga  240
gttctagag  tggtgcaga  gcctcacga  ggtcctgga  aaatgggaa  accagtcgt  300
attcctaaa  aggatcagg  aaagatgaa  gagatgttc  aaatcaacc  gttcaacct  360
atggcgagt  agatgattg  attcaacag  tccttacca  acgtgaggc  agaggggtg  420
aaaacaaaa  tgtacccag  tagccttcc  acgacaagc  tggtgattg  ctttcacaa  480
gaggcgtgg  gcaccctcc  gcgaacagt  cacagtgtc  ttaaccgct  accaagaca  540
atgatagaa  agattgttc  tgtagacga  gccagcgaa  gagactttt  gaaaagacc  600
ctagagagt  atgtgaaaa  gcttaaagt  ccagttcat  taattcgaa  ggaacaacg  660
tctgggttg  tcagagcta  attaaaagg  gctgctgtg  ccaaaggcc  agtgatcac  720
ttcttagat  ctcactgcg  gtgcacagt  gggtggctg  agcctctgt  agcccggat  780
aaacatgac  ggaggacag  ggtgtgtcc  atcatcgat  tgatcagtg  tgacacttt  840
gagtacatg  cgggctctg  tatgaccta  ggtggattc  actggaagc  caatttccg  900
tggtatcct  ttccccaac  agaaatgga  agaaggaaa  gtgaccgga  tcttcctgt  960
agaacacct  caatggctg  aggcctgtt  tcaatagac  gagattact  tcaggaaat  1020
ggaacatat  atgctggaa  ggatatttg  ggaggagaa  acctagaaa  ttcctttag  1080
atttggcag  gtggaggga  tctggaaat  gtgacgtgc  cccacgttg  ccatgtgtt  1140
cggaaagct  cgccgtaca  gttcccggg  ggcacgggg  agatcatca  caagaataa  1200
agacggctc  cggaggtgt  gatggatga  ttcaagaat  tcttctaca  aatttctcc  1260
ggtgttaca  aggtagatt  tggtgatat  tcatcaaga  tcggtctga  acataaact  1320
cagtgcaag  ctttctctt  gtacctaga  aatatttat  ccgattctc  aattcctcg  1380
cactatttc  cattgggag  gatacgaaa  gtggaaaca  atcaatgtc  agataacat  1440
gctagaaaa  agaatgaaa  ggttggaat  tttaattgt  atggtatgg  aggcaatca  1500
gttttctct  acactgcca  caaagaaat  agaacagat  acctttgtt  ggacgtttc  1560
aaacttaat  gcccagtta  catgctcaa  tgccaccac  taaaaggca  ccagctctg  1620
gagtatgac  cagtgaaat  aaccctgca  catgtgaac  gtaaccagt  cctggataa  1680
gccacagaa  aggacagcc  ggtgcccag  atcagagac  gcactggaa  ccggtccca  1740
cagtggctt  ttcgaaatg  cacccttcc  gaaatattc  gagaccaaa  tacaacaaa  1800
aaaggattg  ctgggctac  tcagcataa  ccgaattc  1838



<210> 8456
<211> 559
<212> PRT
<213> Rattus norvegicus
<308> Q10473
<400> 8456

Met Arg Lys Phe Ala Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Val 
  1               5                  10                  15
Trp Val Leu Leu Asp Met Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
             20                  25                  30
Lys Cys Glu Glu Lys Lys Glu Arg Gly Leu Pro Ala Gly Asp Val Leu 
         35                  40                  45
Glu Leu Val Gln Lys Pro His Glu Gly Pro Gly Glu Met Gly Lys Pro 
     50                  55                  60
Val Val Ile Pro Lys Glu Asp Gln Glu Lys Met Lys Glu Met Phe Lys 
 65                  70                  75                  80
Ile Asn Gln Phe Asn Leu Met Ala Ser Glu Met Ile Ala Phe Asn Arg 
                 85                  90                  95
Ser Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro 
             100                105                110
Asp Ser Leu Pro Thr Thr Ser Val Val Ile Val Phe His Asn Glu Ala 
         115                120                125
Trp Ser Thr Leu Leu Arg Thr Val His Ser Val Ile Asn Arg Ser Pro 
     130                135                140
Arg His Met Ile Glu Glu Ile Val Leu Val Asp Asp Ala Ser Glu Arg 
 145                150                155                160
Asp Phe Leu Lys Arg Pro Leu Glu Ser Tyr Val Lys Lys Leu Lys Val 
                 165                170                175
Pro Val His Val Ile Arg Met Glu Gln Arg Ser Gly Leu Ile Arg Ala 
             180                185                190
Arg Leu Lys Gly Ala Ala Val Ser Lys Gly Gln Val Ile Thr Phe Leu 
         195                200                205
Asp Ala His Cys Glu Cys Thr Val Gly Trp Leu Glu Pro Leu Leu Ala 
     210                215                220
Arg Ile Lys His Asp Arg Arg Thr Val Val Cys Pro Ile Ile Asp Val 
 225                230                235                240
Ile Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr 
                 245                250                255
Gly Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln 
             260                265                270
Arg Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr 
         275                280                285
Pro Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asp Tyr Phe Gln 
     290                295                300
Glu Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn 
 305                310                315                320
Leu Glu Ile Ser Phe Arg Ile Trp Gln Cys Gly Gly Thr Leu Glu Ile 
                 325                330                335
Val Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr 
             340                345                350
Thr Phe Pro Gly Gly Thr Gly Gln Ile Ile Asn Lys Asn Asn Arg Arg 
         355                360                365
Leu Ala Glu Val Trp Met Asp Glu Phe Lys Asn Phe Phe Tyr Ile Ile 
     370                375                380
Ser Pro Gly Val Thr Lys Val Asp Tyr Gly Asp Ile Ser Ser Arg Val 
 385                390                395                400
Gly Leu Arg His Lys Leu Gln Cys Lys Pro Phe Ser Trp Tyr Leu Glu 
                 405                410                415
Asn Ile Tyr Pro Asp Ser Gln Ile Pro Arg His Tyr Phe Ser Leu Gly 
             420                425                430
Glu Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Ala Arg 
         435                440                445
Lys Glu Asn Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly 
     450                455                460
Asn Gln Val Phe Ser Tyr Thr Ala Asn Lys Glu Ile Arg Thr Asp Asp 
 465                470                475                480
Leu Cys Leu Asp Val Ser Lys Leu Asn Gly Pro Val Thr Met Leu Lys 
                 485                490                495
Cys His His Leu Lys Gly Asn Gln Leu Trp Glu Tyr Asp Pro Val Lys 
             500                505                510
Leu Thr Leu Gln His Val Asn Ser Asn Gln Cys Leu Asp Lys Ala Thr 
         515                520                525
Glu Glu Asp Ser Gln Val Pro Ser Ile Arg Asp Cys Thr Gly Ser Arg 
     530                535                540
Ser Gln Gln Trp Leu Leu Arg Asn Val Thr Leu Pro Glu Ile Phe 
 545                550                555



<210> 8457
<211> 989
<212> DNA
<213> Homo sapiens
<308> BG026335
<400> 8457

gttatgtga  aaaactaaa  gtaccagtt  atgtaattc  aatggaaca  cgttctgga  60
tgatcagag  tagattaaa  ggagctgct  tgtctaaag  ccaagtgat  accttcctg  120
atgcccatt  tgagtgtac  gtgggatgg  tggagcctc  cttnggccc  ggatcaaac  180
atgagcgag  anngaacag  ggtnngtgt  tcctatcta  cgatgtgta  cagtgtatg  240
atatcttnn  tgatgtact  ntgtgcagg  ctccnntgt  tatgtaaac  ctatgtgnt  300
nggnnttcc  aatctgtga  ggtctccaa  nnntttcgt  tgtgtattc  ctnngttcn  360
cccaannna  agaaaatgg  accaaggaa  ggaaaggtg  tcggattct  ccgtgtcag  420
acacctacc  tggcaggag  ccttttttc  atagacaga  attactttc  ggaaattgg  480
acatatgat  ctggccatt  agagatgca  gcattttga  ctgggagga  ataagaaga  540
aaagggcca  gtgatccag  tctaaactt  gggatattt  tcttcaatt  tgaagagaa  600
atggtgaag  catagaaaa  ttacccgag  gaaataaat  cagtgatat  cttacgcaa  660
aaaaaaagg  aaaaaaaaa  aaacatagc  acaggctga  acagacaac  aagagagag  720
aaaggcaga  acaacagcg  agccacaga  gaccaacca  gacaagaat  tacacaaga  780
acacggagt  ggcagcgta  acaataccc  ggcgcgcag  agacgccac  agcagtatc  840
aaggaagcc  aggcaagag  aaataaagc  gcgggagac  aaaacacag  gcaaagaga  900
agccgcggg  tggaacagc  ctagtgatg  aagcgacca  caggctagc  gcagaaaat  960
tggcgagac  cactgggag  gagtactgn  989



<210> 8458
<211> 105
<212> PRT
<213> Homo sapiens
<308> P09896
<400> 8458

Val Asn Val Pro Lys Thr Arg Arg Thr Phe Cys Lys Lys Cys Gly Lys 
  1               5                  10                  15
His Gln Pro His Lys Val Thr Gln Tyr Lys Lys Gly Lys Asp Ser Leu 
             20                  25                  30
Tyr Ala Gln Gly Lys Arg Arg Tyr Asp Arg Lys Gln Ser Gly Tyr Gly 
         35                  40                  45
Gly Gln Thr Lys Pro Ile Phe Arg Lys Lys Ala Lys Thr Thr Lys Lys 
     50                  55                  60
Ile Val Leu Arg Leu Glu Cys Val Glu Pro Asn Cys Arg Ser Lys Arg 
 65                  70                  75                  80
Met Leu Ala Ile Lys Arg Cys Lys His Phe Glu Leu Gly Gly Asp Lys 
                 85                  90                  95
Lys Arg Lys Gly Gln Val Ile Gln Phe 
             100                105



<210> 8459
<211> 3111
<212> DNA
<213> Rattus norvegicus
<308> U36444
<400> 8459

gttggccac  atggggatg  accaagtga  actgtaggg  aagaaggtg  tgactcgcg  60
gcctggcta  tggctgctg  tcacctcga  gctacaaga  tcctagcaa  atcaaaact  120
accattaac  tacctctac  tccccctgg  gccgttcca  ggccaacgc  acattccct  180
ctgggcacg  aatggccgc  ccccctccc  ctacagaag  ctcttttgg  acacgcagt  240
cgaggtcgc  atggatcgg  tgaagaaga  caaacggca  ctgtcaatg  cactccgag  300
gggccgagg  atagacaag  ccaatggtg  ccctgagca  ataggccta  atgagagtg  360
tggtggtgg  ggcatgacc  ttggagaag  tcccacccg  gttgcccct  gggaacttc  420
ctctattcg  ggcccactc  gctctgcac  aggtctacc  gggtttccc  gtctgctct  480
ggggccatg  acacaaatg  atacgatga  gaaatatat  atattgggg  aaagagagt  540
ttcttgact  caaaggcct  gcctttccc  cactctgca  cagagattg  gcatgaaga  600
atgaagatg  gatctgatg  ggagagtga  caggcttca  ccacatcct  agatgaggt  660
cagtctcca  tgagagtgc  catgcgcaa  cacccccca  gcaagatct  cactgagga  720
atcaacaaa  gcctgtcac  accagctga  atacggctg  ctgagggct  ccttgagaa  780
ctgaccctc  atagcccca  cggtgataa  cctcttagc  ggcgcctcc  gccagtcag  840
ttgtctgag  ttggctttg  aaaactgga  acctacatc  aactagaca  gctgggtga  900
ggtacctat  ccactgtct  caaaggcaa  agcaagctc  cagacaacc  tgtagcact  960
aaggagatc  gactggaac  cgaagaagg  gcaccctgc  ctgctatcc  ggaagtatc  1020
ctgcttaag  acctcaagc  tgccaacat  gtcacacta  atgacatta  ccacacaga  1080
aagtccctc  cccttgtct  tgaatactt  gacaaggac  tgaagcagt  cctggatga  1140
tgtggaaat  tcatcaaca  gcacaatgt  aaactgttc  tgttccagt  gctccgtgg  1200
ctggcctac  gccacaggc  gaaggtgct  caccgagac  tcaagcccc  gaacctact  1260
atcaacgag  ggggagagc  caaactggc  gactttggc  tggcttacg  caagtcaat  1320
cctactaaa  catactcca  cgaagtggt  acactgtgg  accggcccc  tgacatctt  1380
cttgggtcc  cagactact  cggccaaat  gacatgtgg  gtgttggct  catctttta  1440
gagatggcc  caggccggc  cctcttccc  ggctccaca  tggaagaac  gctgcactt  1500
atcttccgc  ttttgggaa  cccaactga  gacacatgg  caggtatcc  gtccaatga  1560
gagtttaga  catacaact  ccccaagta  cgagccgag  cccttctga  gcatgcacc  1620
cgacttgaa  gcgatggag  tgacctcct  accaagctg  tgcagtttg  gggtcgcaa  1680
cggatctct  ctgaggatg  catgaaaca  ccattcttt  tcagcttgg  ggagcggat  1740
cacaaactt  ctgacacta  ttccatatt  gcactaaag  aggtacagc  acaaaagga  1800
gccaacatt  ggtccactt  tatgcctga  tcaggcagg  cagctttcc  tgtggtgga  1860
accgagttc  aagccaagt  ttaagccac  gacagacca  ggccccagc  ggcagcggc  1920
ggagggatg  cacacccct  acaggacag  ccccatctg  aatcctccc  gcttgttgc  1980
tgcttacct  cctgagcca  actcccctg  caacttgtc  cctgccacc  gtccaaaca  2040
cgaactact  gcctggcct  tcaacccaa  cactggcct  tctgctggg  gctaacaaa  2100
ctctcacca  tactttgct  gatgtgtct  tctctgtct  ggtagatgc  ggtggaccg  2160
atggccgtg  cagctttcc  cactaaggc  aggccttcc  ctcttcatc  cactctctc  2220
caggaccac  accccatgg  cagccaggg  tttggagct  gcccaggcc  ggctcttaa  2280
cgactttga  tagaaggta  tgagtgatg  cttgggtct  agcatcatt  gcctgcttc  2340
cacctgtcc  acttgcctc  gttgtatgg  ctttttttt  gtttctttt  ttgtttttt  2400
attatttta  atgaggttc  cacttttta  tgcaatatc  ctgtataca  actggttgg  2460
cactactcc  tgagtgtgg  actcccaca  tattttgtg  aatgaagtc  cactcccac  2520
ctttgagag  tagggaccc  gaccctatt  agatcctca  catcactag  ccctggaat  2580
ggctatggg  aagcatgcc  cagccactc  ccttcctcc  ctacctagc  ttcccagct  2640
tagggggac  tgagaacta  cagagagtg  gagatggac  tggtggggc  tactttttc  2700
ctccttcag  cccgtagcc  gggcctcct  ccttctcag  gtcttcccc  gcccagctc  2760
gcctagccc  cctgccctg  cctactcgg  gctgttgag  aggggctct  cctggaatc  2820
agcagctta  tgaggagcc  tatataata  gtgcacaag  aggaggaca  gtgggagct  2880
gtgcccaat  gttacaccc  aatccctag  agggtcagg  aggccaagg  cagtctcct  2940
gatggatgg  ttgctcccc  tactccacc  taagccttg  gacccttaa  cagggtggg  3000
gggcaaggg  gggtgccct  ctagtgggg  ttgggggga  tgggttcct  aatgcacca  3060
aatcgctgt  tgaaatatt  aaaaaaagt  taaagtgaa  aaaaaaaaa  a  3111



<210> 8460
<211> 462
<212> PRT
<213> Rattus norvegicus
<308> U36444
<400> 8460

Met Tyr Thr Asn Gly Tyr Asp Glu Glu Ile Tyr Tyr Ile Gly Gly Lys 
  1               5                  10                  15
Arg Val Phe Leu Thr Pro Lys Ala Trp Pro Phe Pro His Ser Ala Pro 
             20                  25                  30
Glu Ile Val His Glu Asp Met Lys Met Gly Ser Asp Gly Glu Ser Asp 
         35                  40                  45
Gln Ala Ser Ala Thr Ser Ser Asp Glu Val Gln Ser Pro Val Arg Val 
     50                  55                  60
Arg Met Arg Asn His Pro Pro Arg Lys Ile Ser Thr Glu Asp Ile Asn 
 65                  70                  75                  80
Lys Cys Leu Ser Leu Pro Ala Asp Ile Arg Leu Pro Glu Gly Tyr Leu 
                 85                  90                  95
Glu Lys Leu Thr Leu Asn Ser Pro Ile Gly Asp Lys Pro Leu Ser Arg 
             100                105                110
Arg Leu Arg Pro Val Ser Leu Ser Glu Ile Gly Phe Gly Lys Leu Glu 
         115                120                125
Thr Tyr Ile Lys Leu Asp Lys Leu Gly Glu Gly Thr Tyr Ala Thr Val 
     130                135                140
Tyr Lys Gly Lys Ser Lys Leu Thr Asp Asn Leu Val Ala Leu Lys Glu 
 145                150                155                160
Ile Arg Leu Glu His Glu Glu Gly Ala Pro Cys Thr Ala Ile Arg Glu 
                 165                170                175
Val Ser Leu Leu Lys Asp Leu Lys His Ala Asn Ile Val Thr Leu His 
             180                185                190
Asp Ile Ile His Thr Glu Lys Ser Leu Thr Leu Val Phe Glu Tyr Leu 
         195                200                205
Asp Lys Asp Leu Lys Gln Tyr Leu Asp Asp Cys Gly Asn Val Ile Asn 
     210                215                220
Met His Asn Val Lys Leu Phe Leu Phe Gln Leu Leu Arg Gly Leu Ala 
 225                230                235                240
Tyr Cys His Arg Gln Lys Val Leu His Arg Asp Leu Lys Pro Gln Asn 
                 245                250                255
Leu Leu Ile Asn Glu Arg Gly Glu Leu Lys Leu Ala Asp Phe Gly Leu 
             260                265                270
Ala Tyr Ala Lys Ser Ile Pro Thr Lys Thr Tyr Ser Asn Glu Val Val 
         275                280                285
Thr Leu Trp Tyr Arg Pro Pro Asp Ile Leu Leu Gly Ser Thr Asp Tyr 
     290                295                300
Ser Gly Gln Ile Asp Met Trp Gly Val Gly Cys Ile Phe Tyr Glu Met 
 305                310                315                320
Ala Thr Gly Arg Pro Leu Phe Pro Gly Ser Thr Val Glu Glu Gln Leu 
                 325                330                335
His Phe Ile Phe Arg Ile Leu Gly Thr Pro Thr Glu Asp Thr Trp Pro 
             340                345                350
Gly Ile Leu Ser Asn Glu Glu Phe Arg Thr Tyr Asn Tyr Pro Lys Tyr 
         355                360                365
Arg Ala Glu Ala Leu Leu Arg His Ala Pro Arg Leu Glu Cys Asp Gly 
     370                375                380
Ala Asp Leu Leu Thr Lys Leu Leu Gln Phe Glu Gly Arg Asn Arg Ile 
 385                390                395                400
Ser Ala Glu Asp Ala Met Lys His Pro Phe Phe Leu Ser Leu Gly Glu 
                 405                410                415
Arg Ile His Lys Leu Pro Asp Thr Thr Ser Ile Phe Ala Leu Lys Glu 
             420                425                430
Val Gln Leu Gln Lys Glu Ala Asn Ile Arg Ser Thr Ser Met Pro Asp 
         435                440                445
Ser Gly Arg Pro Ala Phe Arg Val Val Asp Thr Glu Phe Ter 
     450                455                460



<210> 8461
<211> 3131
<212> DNA
<213> Homo sapiens
<308> NM_006201
<400> 8461

gcggagcgc  gcgcgcgcg  cggttgggc  gttggctgt  cggccctgg  atccgccgc  60
actccgcga  cagaccgct  tgtgccgcg  gccgccgtg  gcactcgga  tcaagccgg  120
gccaacgag  ccgggggca  cgcccgcag  ggccaagct  atggccggc  gagcgggac  180
ccgcctccg  ctcagccac  gccgccgcc  ccgcctcct  ctcctcagc  ggcggcggc  240
cgggcccag  aaccatggc  gaagactac  gggacgggc  cctgcggcg  acaggagga  300
aaggaggtc  cgcggcctc  tcccgggcc  ccgccccag  cgccgccgc  ccggccccg  360
ggctctgag  ttgctcgcg  gcccccgcc  atcgccatg  atcggatga  gaagatcaa  420
cggcagctg  caatgacac  ccgaggtgg  cgaggcata  acaagacca  tggtgcccc  480
gagcagata  gcctggatg  gagtggtgg  ggtggcggc  gtgaccctg  agaggcccc  540
acacgtgct  ctcctgggg  acttcgttc  gcacggggc  cactcagct  tgcaccaga  600
attgtgcac  aggacttga  gatggggtc  gatggggag  gtgaccagg  ttcagccac  660
tcctcggat  aggtgcagt  tccagtgag  gtgcgtatg  gcaaccatc  cccacgcaa  720
atctccact  aggacatca  caagcgcct  tcactacca  ctgacatcc  gctgcctga  780
ggctacctg  agaagctga  cctcaatag  cccatcttt  acaagcccc  cagccgccg  840
ctccgtcgt  tcagcctat  tgagattgg  tttgggaaa  tggagacct  cattaagct  900
gacaaactg  gcgagggta  ctatgccac  gtctacaaa  gcaaaagca  gctcacaga  960
aaccttgtg  cactcaagg  gatcagact  gaacatgaa  agggggcac  ctgcaccgc  1020
atccgggaa  tgtccctgc  caaggacct  aaacacgcc  acatcgtta  gctacatga  1080
attatccac  cggagaagt  cctcaccct  gtctttgag  acctggaca  ggacctgaa  1140
cagtacctg  atgactgtg  gaacatcat  aacatgcac  acgtgaaac  gttcctgtt  1200
cagctgctc  gtggcctgg  ctactgcca  cggcagaag  tgctacacc  agacctcaa  1260
ccccagaac  tgctcatca  cgagagggg  gagctcaag  tggctgact  tggcctggc  1320
cgagccaag  caatcccaa  aaagacata  tccaatgag  tggtgacac  gtggtaccg  1380
ccccctgac  tcctgcttg  gtccacgga  tactccact  agattgaca  gtggggtgt  1440
ggctgcatc  tctatgaga  ggccacagg  cgtcccctc  ttccgggct  cacggtgga  1500
gaacagcta  acttcatct  ccgtatctt  ggaacccca  ctgaggaga  gtggccagg  1560
atcctgtcc  acgaggagt  caagacata  aactacccc  agtaccgag  cgaggccct  1620
ttgagccac  caccccgac  tgatagcga  ggggccgac  tcctcacca  gctgttgca  1680
tttgagggt  gaaatcgga  ctccgcaga  gatgccatg  aacatccat  cttcctcag  1740
ctgggggag  ggatccaca  acttcctga  actacttcc  tatttgcac  aaaggagat  1800
cagctacaa  aggaggcca  ccttcggtc  tcgtcgatg  ctgactcag  caggccagc  1860
ttccgcgtg  tggacaccg  gttctaagc  acagaccga  gccccagca  gcagcggct  1920
gagggatgc  acacccctc  cagggcagc  cccaactac  tcttccctg  ttactctct  1980
cctacctgc  tgagccatg  tcacctgcc  acttgtccc  tgctgcctg  ccaaacacc  2040
caccattgg  ctgtcaacc  acccattgg  ctgtctgct  ggtgctaac  aagctctca  2100
cactccttc  cttggtctg  ctgtctctg  cttggtagt  gccggtgga  agcatggcc  2160
tgccagcct  ccacactga  gccaggtct  ccccccatc  taccagccc  caggaccac  2220
accccacgg  cagccaggg  tccagagct  gcccaggct  gggatctcg  ctcagacaa  2280
atggtgaca  tgccttgag  ctgaggcat  ctctgcctg  tttcctgcc  gccccacct  2340
cctcatatt  tgtgggcct  tttttgttt  tttcattca  tgttttttt  ttttttaat  2400
attttaaat  agatttttg  tttttttaa  tgcaatatc  ctgtataca  actggctgg  2460
ccccacccc  tgcgtgtgg  cctcccaca  tattttgtg  aatgaagcc  tgctcccag  2520
ctttcagag  cagggacac  gcccctatt  ggaaccctg  tcatcacca  accctggga  2580
tggctatgg  aaagcatgc  acagccact  gccttccta  ccccgcccg  catccccag  2640
tgcaggggg  tctggggac  accagagac  ctgggaaat  gacaaggtg  ggggcccca  2700
tctttctct  ctgcagtcc  gtagctggg  cctccttcc  tctcagggt  tccccagcc  2760
agtcccctt  ctcccatcc  actcggtgc  gttgggtag  ggccctgcc  ggaactgac  2820
agctcagcg  ggagccata  tgtgcatat  tgcacaagc  gggttgggg  aggggggtg  2880
gaggggttg  gcccaggtg  tgcccccta  ctcctgggg  gggtgaggc  gggcaggga  2940
agtctccag  gtcagtccc  ggatgggtg  ttacctccc  ttcctccac  ctaagccct  3000
gggccctga  atggggtgg  agggcaggg  tgggagccc  cctagtggg  ttggggggt  3060
gggttcctg  atgcaccat  atcgctgta  gaaatatta  aaagtctaa  gtgaaaaaa  3120
aaaaaaaaa  a  3131



<210> 8462
<211> 496
<212> PRT
<213> Homo sapiens
<308> Q00536
<400> 8462

Met Asp Arg Met Lys Lys Ile Lys Arg Gln Leu Ser Met Thr Leu Arg 
  1               5                  10                  15
Gly Gly Arg Gly Ile Asp Lys Thr Asn Gly Ala Pro Glu Gln Ile Gly 
             20                  25                  30
Leu Asp Glu Ser Gly Gly Gly Gly Gly Ser Asp Pro Gly Glu Ala Pro 
         35                  40                  45
Thr Arg Ala Ala Pro Gly Glu Leu Arg Ser Ala Arg Gly Pro Leu Ser 
     50                  55                  60
Ser Ala Pro Glu Ile Val His Glu Asp Leu Lys Met Gly Ser Asp Gly 
 65                  70                  75                  80
Glu Ser Asp Gln Ala Ser Ala Thr Ser Ser Asp Glu Val Gln Ser Pro 
                 85                  90                  95
Val Arg Val Arg Met Arg Asn His Pro Pro Arg Lys Ile Ser Thr Glu 
             100                105                110
Asp Ile Asn Lys Arg Leu Ser Leu Pro Ala Asp Ile Arg Leu Pro Glu 
         115                120                125
Gly Tyr Leu Glu Lys Leu Thr Leu Asn Ser Pro Ile Phe Asp Lys Pro 
     130                135                140
Leu Ser Arg Arg Leu Arg Arg Val Ser Leu Ser Glu Ile Gly Phe Gly 
 145                150                155                160
Lys Leu Glu Thr Tyr Ile Lys Leu Asp Lys Leu Gly Glu Gly Thr Tyr 
                 165                170                175
Ala Thr Val Tyr Lys Gly Lys Ser Lys Leu Thr Asp Asn Leu Val Ala 
             180                185                190
Leu Lys Glu Ile Arg Leu Glu His Glu Glu Gly Ala Pro Cys Thr Ala 
         195                200                205
Ile Arg Glu Val Ser Leu Leu Lys Asp Leu Lys His Ala Asn Ile Val 
     210                215                220
Thr Leu His Asp Ile Ile His Thr Glu Lys Ser Leu Thr Leu Val Phe 
 225                230                235                240
Glu Tyr Leu Asp Lys Asp Leu Lys Gln Tyr Leu Asp Asp Cys Gly Asn 
                 245                250                255
Ile Ile Asn Met His Asn Val Lys Leu Phe Leu Phe Gln Leu Leu Arg 
             260                265                270
Gly Leu Ala Tyr Cys His Arg Gln Lys Val Leu His Arg Asp Leu Lys 
         275                280                285
Pro Gln Asn Leu Leu Ile Asn Glu Arg Gly Glu Leu Lys Leu Ala Asp 
     290                295                300
Phe Gly Leu Ala Arg Ala Lys Ser Ile Pro Thr Lys Thr Tyr Ser Asn 
 305                310                315                320
Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Ile Leu Leu Gly Ser 
                 325                330                335
Thr Asp Tyr Ser Thr Gln Ile Asp Met Trp Gly Val Gly Cys Ile Phe 
             340                345                350
Tyr Glu Met Ala Thr Gly Arg Pro Leu Phe Pro Gly Ser Thr Val Glu 
         355                360                365
Glu Gln Leu His Phe Ile Phe Arg Ile Leu Gly Thr Pro Thr Glu Glu 
     370                375                380
Thr Trp Pro Gly Ile Leu Ser Asn Glu Glu Phe Lys Thr Tyr Asn Tyr 
 385                390                395                400
Pro Lys Tyr Arg Ala Glu Ala Leu Leu Ser His Ala Pro Arg Leu Asp 
                 405                410                415
Ser Asp Gly Ala Asp Leu Leu Thr Lys Leu Leu Gln Phe Glu Gly Arg 
             420                425                430
Asn Arg Ile Ser Ala Glu Asp Ala Met Lys His Pro Phe Phe Leu Ser 
         435                440                445
Leu Gly Glu Arg Ile His Lys Leu Pro Asp Thr Thr Ser Ile Phe Ala 
     450                455                460
Leu Lys Glu Ile Gln Leu Gln Lys Glu Ala Ser Leu Arg Ser Ser Ser 
 465                470                475                480
Met Pro Asp Ser Gly Arg Pro Ala Phe Arg Val Val Asp Thr Glu Phe 
                 485                490                495



<210> 8463
<211> 3111
<212> DNA
<213> Rattus norvegicus
<308> U36444
<400> 8463

gttggccac  atggggatg  accaagtga  actgtaggg  aagaaggtg  tgactcgcg  60
gcctggcta  tggctgctg  tcacctcga  gctacaaga  tcctagcaa  atcaaaact  120
accattaac  tacctctac  tccccctgg  gccgttcca  ggccaacgc  acattccct  180
ctgggcacg  aatggccgc  ccccctccc  ctacagaag  ctcttttgg  acacgcagt  240
cgaggtcgc  atggatcgg  tgaagaaga  caaacggca  ctgtcaatg  cactccgag  300
gggccgagg  atagacaag  ccaatggtg  ccctgagca  ataggccta  atgagagtg  360
tggtggtgg  ggcatgacc  ttggagaag  tcccacccg  gttgcccct  gggaacttc  420
ctctattcg  ggcccactc  gctctgcac  aggtctacc  gggtttccc  gtctgctct  480
ggggccatg  acacaaatg  atacgatga  gaaatatat  atattgggg  aaagagagt  540
ttcttgact  caaaggcct  gcctttccc  cactctgca  cagagattg  gcatgaaga  600
atgaagatg  gatctgatg  ggagagtga  caggcttca  ccacatcct  agatgaggt  660
cagtctcca  tgagagtgc  catgcgcaa  cacccccca  gcaagatct  cactgagga  720
atcaacaaa  gcctgtcac  accagctga  atacggctg  ctgagggct  ccttgagaa  780
ctgaccctc  atagcccca  cggtgataa  cctcttagc  ggcgcctcc  gccagtcag  840
ttgtctgag  ttggctttg  aaaactgga  acctacatc  aactagaca  gctgggtga  900
ggtacctat  ccactgtct  caaaggcaa  agcaagctc  cagacaacc  tgtagcact  960
aaggagatc  gactggaac  cgaagaagg  gcaccctgc  ctgctatcc  ggaagtatc  1020
ctgcttaag  acctcaagc  tgccaacat  gtcacacta  atgacatta  ccacacaga  1080
aagtccctc  cccttgtct  tgaatactt  gacaaggac  tgaagcagt  cctggatga  1140
tgtggaaat  tcatcaaca  gcacaatgt  aaactgttc  tgttccagt  gctccgtgg  1200
ctggcctac  gccacaggc  gaaggtgct  caccgagac  tcaagcccc  gaacctact  1260
atcaacgag  ggggagagc  caaactggc  gactttggc  tggcttacg  caagtcaat  1320
cctactaaa  catactcca  cgaagtggt  acactgtgg  accggcccc  tgacatctt  1380
cttgggtcc  cagactact  cggccaaat  gacatgtgg  gtgttggct  catctttta  1440
gagatggcc  caggccggc  cctcttccc  ggctccaca  tggaagaac  gctgcactt  1500
atcttccgc  ttttgggaa  cccaactga  gacacatgg  caggtatcc  gtccaatga  1560
gagtttaga  catacaact  ccccaagta  cgagccgag  cccttctga  gcatgcacc  1620
cgacttgaa  gcgatggag  tgacctcct  accaagctg  tgcagtttg  gggtcgcaa  1680
cggatctct  ctgaggatg  catgaaaca  ccattcttt  tcagcttgg  ggagcggat  1740
cacaaactt  ctgacacta  ttccatatt  gcactaaag  aggtacagc  acaaaagga  1800
gccaacatt  ggtccactt  tatgcctga  tcaggcagg  cagctttcc  tgtggtgga  1860
accgagttc  aagccaagt  ttaagccac  gacagacca  ggccccagc  ggcagcggc  1920
ggagggatg  cacacccct  acaggacag  ccccatctg  aatcctccc  gcttgttgc  1980
tgcttacct  cctgagcca  actcccctg  caacttgtc  cctgccacc  gtccaaaca  2040
cgaactact  gcctggcct  tcaacccaa  cactggcct  tctgctggg  gctaacaaa  2100
ctctcacca  tactttgct  gatgtgtct  tctctgtct  ggtagatgc  ggtggaccg  2160
atggccgtg  cagctttcc  cactaaggc  aggccttcc  ctcttcatc  cactctctc  2220
caggaccac  accccatgg  cagccaggg  tttggagct  gcccaggcc  ggctcttaa  2280
cgactttga  tagaaggta  tgagtgatg  cttgggtct  agcatcatt  gcctgcttc  2340
cacctgtcc  acttgcctc  gttgtatgg  ctttttttt  gtttctttt  ttgtttttt  2400
attatttta  atgaggttc  cacttttta  tgcaatatc  ctgtataca  actggttgg  2460
cactactcc  tgagtgtgg  actcccaca  tattttgtg  aatgaagtc  cactcccac  2520
ctttgagag  tagggaccc  gaccctatt  agatcctca  catcactag  ccctggaat  2580
ggctatggg  aagcatgcc  cagccactc  ccttcctcc  ctacctagc  ttcccagct  2640
tagggggac  tgagaacta  cagagagtg  gagatggac  tggtggggc  tactttttc  2700
ctccttcag  cccgtagcc  gggcctcct  ccttctcag  gtcttcccc  gcccagctc  2760
gcctagccc  cctgccctg  cctactcgg  gctgttgag  aggggctct  cctggaatc  2820
agcagctta  tgaggagcc  tatataata  gtgcacaag  aggaggaca  gtgggagct  2880
gtgcccaat  gttacaccc  aatccctag  agggtcagg  aggccaagg  cagtctcct  2940
gatggatgg  ttgctcccc  tactccacc  taagccttg  gacccttaa  cagggtggg  3000
gggcaaggg  gggtgccct  ctagtgggg  ttgggggga  tgggttcct  aatgcacca  3060
aatcgctgt  tgaaatatt  aaaaaaagt  taaagtgaa  aaaaaaaaa  a  3111



<210> 8464
<211> 462
<212> PRT
<213> Rattus norvegicus
<308> U36444
<400> 8464

Met Tyr Thr Asn Gly Tyr Asp Glu Glu Ile Tyr Tyr Ile Gly Gly Lys 
  1               5                  10                  15
Arg Val Phe Leu Thr Pro Lys Ala Trp Pro Phe Pro His Ser Ala Pro 
             20                  25                  30
Glu Ile Val His Glu Asp Met Lys Met Gly Ser Asp Gly Glu Ser Asp 
         35                  40                  45
Gln Ala Ser Ala Thr Ser Ser Asp Glu Val Gln Ser Pro Val Arg Val 
     50                  55                  60
Arg Met Arg Asn His Pro Pro Arg Lys Ile Ser Thr Glu Asp Ile Asn 
 65                  70                  75                  80
Lys Cys Leu Ser Leu Pro Ala Asp Ile Arg Leu Pro Glu Gly Tyr Leu 
                 85                  90                  95
Glu Lys Leu Thr Leu Asn Ser Pro Ile Gly Asp Lys Pro Leu Ser Arg 
             100                105                110
Arg Leu Arg Pro Val Ser Leu Ser Glu Ile Gly Phe Gly Lys Leu Glu 
         115                120                125
Thr Tyr Ile Lys Leu Asp Lys Leu Gly Glu Gly Thr Tyr Ala Thr Val 
     130                135                140
Tyr Lys Gly Lys Ser Lys Leu Thr Asp Asn Leu Val Ala Leu Lys Glu 
 145                150                155                160
Ile Arg Leu Glu His Glu Glu Gly Ala Pro Cys Thr Ala Ile Arg Glu 
                 165                170                175
Val Ser Leu Leu Lys Asp Leu Lys His Ala Asn Ile Val Thr Leu His 
             180                185                190
Asp Ile Ile His Thr Glu Lys Ser Leu Thr Leu Val Phe Glu Tyr Leu 
         195                200                205
Asp Lys Asp Leu Lys Gln Tyr Leu Asp Asp Cys Gly Asn Val Ile Asn 
     210                215                220
Met His Asn Val Lys Leu Phe Leu Phe Gln Leu Leu Arg Gly Leu Ala 
 225                230                235                240
Tyr Cys His Arg Gln Lys Val Leu His Arg Asp Leu Lys Pro Gln Asn 
                 245                250                255
Leu Leu Ile Asn Glu Arg Gly Glu Leu Lys Leu Ala Asp Phe Gly Leu 
             260                265                270
Ala Tyr Ala Lys Ser Ile Pro Thr Lys Thr Tyr Ser Asn Glu Val Val 
         275                280                285
Thr Leu Trp Tyr Arg Pro Pro Asp Ile Leu Leu Gly Ser Thr Asp Tyr 
     290                295                300
Ser Gly Gln Ile Asp Met Trp Gly Val Gly Cys Ile Phe Tyr Glu Met 
 305                310                315                320
Ala Thr Gly Arg Pro Leu Phe Pro Gly Ser Thr Val Glu Glu Gln Leu 
                 325                330                335
His Phe Ile Phe Arg Ile Leu Gly Thr Pro Thr Glu Asp Thr Trp Pro 
             340                345                350
Gly Ile Leu Ser Asn Glu Glu Phe Arg Thr Tyr Asn Tyr Pro Lys Tyr 
         355                360                365
Arg Ala Glu Ala Leu Leu Arg His Ala Pro Arg Leu Glu Cys Asp Gly 
     370                375                380
Ala Asp Leu Leu Thr Lys Leu Leu Gln Phe Glu Gly Arg Asn Arg Ile 
 385                390                395                400
Ser Ala Glu Asp Ala Met Lys His Pro Phe Phe Leu Ser Leu Gly Glu 
                 405                410                415
Arg Ile His Lys Leu Pro Asp Thr Thr Ser Ile Phe Ala Leu Lys Glu 
             420                425                430
Val Gln Leu Gln Lys Glu Ala Asn Ile Arg Ser Thr Ser Met Pro Asp 
         435                440                445
Ser Gly Arg Pro Ala Phe Arg Val Val Asp Thr Glu Phe Ter 
     450                455                460



<210> 8465
<211> 3131
<212> DNA
<213> Homo sapiens
<308> NM_006201
<400> 8465

gcggagcgc  gcgcgcgcg  cggttgggc  gttggctgt  cggccctgg  atccgccgc  60
actccgcga  cagaccgct  tgtgccgcg  gccgccgtg  gcactcgga  tcaagccgg  120
gccaacgag  ccgggggca  cgcccgcag  ggccaagct  atggccggc  gagcgggac  180
ccgcctccg  ctcagccac  gccgccgcc  ccgcctcct  ctcctcagc  ggcggcggc  240
cgggcccag  aaccatggc  gaagactac  gggacgggc  cctgcggcg  acaggagga  300
aaggaggtc  cgcggcctc  tcccgggcc  ccgccccag  cgccgccgc  ccggccccg  360
ggctctgag  ttgctcgcg  gcccccgcc  atcgccatg  atcggatga  gaagatcaa  420
cggcagctg  caatgacac  ccgaggtgg  cgaggcata  acaagacca  tggtgcccc  480
gagcagata  gcctggatg  gagtggtgg  ggtggcggc  gtgaccctg  agaggcccc  540
acacgtgct  ctcctgggg  acttcgttc  gcacggggc  cactcagct  tgcaccaga  600
attgtgcac  aggacttga  gatggggtc  gatggggag  gtgaccagg  ttcagccac  660
tcctcggat  aggtgcagt  tccagtgag  gtgcgtatg  gcaaccatc  cccacgcaa  720
atctccact  aggacatca  caagcgcct  tcactacca  ctgacatcc  gctgcctga  780
ggctacctg  agaagctga  cctcaatag  cccatcttt  acaagcccc  cagccgccg  840
ctccgtcgt  tcagcctat  tgagattgg  tttgggaaa  tggagacct  cattaagct  900
gacaaactg  gcgagggta  ctatgccac  gtctacaaa  gcaaaagca  gctcacaga  960
aaccttgtg  cactcaagg  gatcagact  gaacatgaa  agggggcac  ctgcaccgc  1020
atccgggaa  tgtccctgc  caaggacct  aaacacgcc  acatcgtta  gctacatga  1080
attatccac  cggagaagt  cctcaccct  gtctttgag  acctggaca  ggacctgaa  1140
cagtacctg  atgactgtg  gaacatcat  aacatgcac  acgtgaaac  gttcctgtt  1200
cagctgctc  gtggcctgg  ctactgcca  cggcagaag  tgctacacc  agacctcaa  1260
ccccagaac  tgctcatca  cgagagggg  gagctcaag  tggctgact  tggcctggc  1320
cgagccaag  caatcccaa  aaagacata  tccaatgag  tggtgacac  gtggtaccg  1380
ccccctgac  tcctgcttg  gtccacgga  tactccact  agattgaca  gtggggtgt  1440
ggctgcatc  tctatgaga  ggccacagg  cgtcccctc  ttccgggct  cacggtgga  1500
gaacagcta  acttcatct  ccgtatctt  ggaacccca  ctgaggaga  gtggccagg  1560
atcctgtcc  acgaggagt  caagacata  aactacccc  agtaccgag  cgaggccct  1620
ttgagccac  caccccgac  tgatagcga  ggggccgac  tcctcacca  gctgttgca  1680
tttgagggt  gaaatcgga  ctccgcaga  gatgccatg  aacatccat  cttcctcag  1740
ctgggggag  ggatccaca  acttcctga  actacttcc  tatttgcac  aaaggagat  1800
cagctacaa  aggaggcca  ccttcggtc  tcgtcgatg  ctgactcag  caggccagc  1860
ttccgcgtg  tggacaccg  gttctaagc  acagaccga  gccccagca  gcagcggct  1920
gagggatgc  acacccctc  cagggcagc  cccaactac  tcttccctg  ttactctct  1980
cctacctgc  tgagccatg  tcacctgcc  acttgtccc  tgctgcctg  ccaaacacc  2040
caccattgg  ctgtcaacc  acccattgg  ctgtctgct  ggtgctaac  aagctctca  2100
cactccttc  cttggtctg  ctgtctctg  cttggtagt  gccggtgga  agcatggcc  2160
tgccagcct  ccacactga  gccaggtct  ccccccatc  taccagccc  caggaccac  2220
accccacgg  cagccaggg  tccagagct  gcccaggct  gggatctcg  ctcagacaa  2280
atggtgaca  tgccttgag  ctgaggcat  ctctgcctg  tttcctgcc  gccccacct  2340
cctcatatt  tgtgggcct  tttttgttt  tttcattca  tgttttttt  ttttttaat  2400
attttaaat  agatttttg  tttttttaa  tgcaatatc  ctgtataca  actggctgg  2460
ccccacccc  tgcgtgtgg  cctcccaca  tattttgtg  aatgaagcc  tgctcccag  2520
ctttcagag  cagggacac  gcccctatt  ggaaccctg  tcatcacca  accctggga  2580
tggctatgg  aaagcatgc  acagccact  gccttccta  ccccgcccg  catccccag  2640
tgcaggggg  tctggggac  accagagac  ctgggaaat  gacaaggtg  ggggcccca  2700
tctttctct  ctgcagtcc  gtagctggg  cctccttcc  tctcagggt  tccccagcc  2760
agtcccctt  ctcccatcc  actcggtgc  gttgggtag  ggccctgcc  ggaactgac  2820
agctcagcg  ggagccata  tgtgcatat  tgcacaagc  gggttgggg  aggggggtg  2880
gaggggttg  gcccaggtg  tgcccccta  ctcctgggg  gggtgaggc  gggcaggga  2940
agtctccag  gtcagtccc  ggatgggtg  ttacctccc  ttcctccac  ctaagccct  3000
gggccctga  atggggtgg  agggcaggg  tgggagccc  cctagtggg  ttggggggt  3060
gggttcctg  atgcaccat  atcgctgta  gaaatatta  aaagtctaa  gtgaaaaaa  3120
aaaaaaaaa  a  3131



<210> 8466
<211> 496
<212> PRT
<213> Homo sapiens
<308> Q00536
<400> 8466

Met Asp Arg Met Lys Lys Ile Lys Arg Gln Leu Ser Met Thr Leu Arg 
  1               5                  10                  15
Gly Gly Arg Gly Ile Asp Lys Thr Asn Gly Ala Pro Glu Gln Ile Gly 
             20                  25                  30
Leu Asp Glu Ser Gly Gly Gly Gly Gly Ser Asp Pro Gly Glu Ala Pro 
         35                  40                  45
Thr Arg Ala Ala Pro Gly Glu Leu Arg Ser Ala Arg Gly Pro Leu Ser 
     50                  55                  60
Ser Ala Pro Glu Ile Val His Glu Asp Leu Lys Met Gly Ser Asp Gly 
 65                  70                  75                  80
Glu Ser Asp Gln Ala Ser Ala Thr Ser Ser Asp Glu Val Gln Ser Pro 
                 85                  90                  95
Val Arg Val Arg Met Arg Asn His Pro Pro Arg Lys Ile Ser Thr Glu 
             100                105                110
Asp Ile Asn Lys Arg Leu Ser Leu Pro Ala Asp Ile Arg Leu Pro Glu 
         115                120                125
Gly Tyr Leu Glu Lys Leu Thr Leu Asn Ser Pro Ile Phe Asp Lys Pro 
     130                135                140
Leu Ser Arg Arg Leu Arg Arg Val Ser Leu Ser Glu Ile Gly Phe Gly 
 145                150                155                160
Lys Leu Glu Thr Tyr Ile Lys Leu Asp Lys Leu Gly Glu Gly Thr Tyr 
                 165                170                175
Ala Thr Val Tyr Lys Gly Lys Ser Lys Leu Thr Asp Asn Leu Val Ala 
             180                185                190
Leu Lys Glu Ile Arg Leu Glu His Glu Glu Gly Ala Pro Cys Thr Ala 
         195                200                205
Ile Arg Glu Val Ser Leu Leu Lys Asp Leu Lys His Ala Asn Ile Val 
     210                215                220
Thr Leu His Asp Ile Ile His Thr Glu Lys Ser Leu Thr Leu Val Phe 
 225                230                235                240
Glu Tyr Leu Asp Lys Asp Leu Lys Gln Tyr Leu Asp Asp Cys Gly Asn 
                 245                250                255
Ile Ile Asn Met His Asn Val Lys Leu Phe Leu Phe Gln Leu Leu Arg 
             260                265                270
Gly Leu Ala Tyr Cys His Arg Gln Lys Val Leu His Arg Asp Leu Lys 
         275                280                285
Pro Gln Asn Leu Leu Ile Asn Glu Arg Gly Glu Leu Lys Leu Ala Asp 
     290                295                300
Phe Gly Leu Ala Arg Ala Lys Ser Ile Pro Thr Lys Thr Tyr Ser Asn 
 305                310                315                320
Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Ile Leu Leu Gly Ser 
                 325                330                335
Thr Asp Tyr Ser Thr Gln Ile Asp Met Trp Gly Val Gly Cys Ile Phe 
             340                345                350
Tyr Glu Met Ala Thr Gly Arg Pro Leu Phe Pro Gly Ser Thr Val Glu 
         355                360                365
Glu Gln Leu His Phe Ile Phe Arg Ile Leu Gly Thr Pro Thr Glu Glu 
     370                375                380
Thr Trp Pro Gly Ile Leu Ser Asn Glu Glu Phe Lys Thr Tyr Asn Tyr 
 385                390                395                400
Pro Lys Tyr Arg Ala Glu Ala Leu Leu Ser His Ala Pro Arg Leu Asp 
                 405                410                415
Ser Asp Gly Ala Asp Leu Leu Thr Lys Leu Leu Gln Phe Glu Gly Arg 
             420                425                430
Asn Arg Ile Ser Ala Glu Asp Ala Met Lys His Pro Phe Phe Leu Ser 
         435                440                445
Leu Gly Glu Arg Ile His Lys Leu Pro Asp Thr Thr Ser Ile Phe Ala 
     450                455                460
Leu Lys Glu Ile Gln Leu Gln Lys Glu Ala Ser Leu Arg Ser Ser Ser 
 465                470                475                480
Met Pro Asp Ser Gly Arg Pro Ala Phe Arg Val Val Asp Thr Glu Phe 
                 485                490                495



<210> 8467
<211> 3111
<212> DNA
<213> Rattus norvegicus
<308> U36444
<400> 8467

gttggccac  atggggatg  accaagtga  actgtaggg  aagaaggtg  tgactcgcg  60
gcctggcta  tggctgctg  tcacctcga  gctacaaga  tcctagcaa  atcaaaact  120
accattaac  tacctctac  tccccctgg  gccgttcca  ggccaacgc  acattccct  180
ctgggcacg  aatggccgc  ccccctccc  ctacagaag  ctcttttgg  acacgcagt  240
cgaggtcgc  atggatcgg  tgaagaaga  caaacggca  ctgtcaatg  cactccgag  300
gggccgagg  atagacaag  ccaatggtg  ccctgagca  ataggccta  atgagagtg  360
tggtggtgg  ggcatgacc  ttggagaag  tcccacccg  gttgcccct  gggaacttc  420
ctctattcg  ggcccactc  gctctgcac  aggtctacc  gggtttccc  gtctgctct  480
ggggccatg  acacaaatg  atacgatga  gaaatatat  atattgggg  aaagagagt  540
ttcttgact  caaaggcct  gcctttccc  cactctgca  cagagattg  gcatgaaga  600
atgaagatg  gatctgatg  ggagagtga  caggcttca  ccacatcct  agatgaggt  660
cagtctcca  tgagagtgc  catgcgcaa  cacccccca  gcaagatct  cactgagga  720
atcaacaaa  gcctgtcac  accagctga  atacggctg  ctgagggct  ccttgagaa  780
ctgaccctc  atagcccca  cggtgataa  cctcttagc  ggcgcctcc  gccagtcag  840
ttgtctgag  ttggctttg  aaaactgga  acctacatc  aactagaca  gctgggtga  900
ggtacctat  ccactgtct  caaaggcaa  agcaagctc  cagacaacc  tgtagcact  960
aaggagatc  gactggaac  cgaagaagg  gcaccctgc  ctgctatcc  ggaagtatc  1020
ctgcttaag  acctcaagc  tgccaacat  gtcacacta  atgacatta  ccacacaga  1080
aagtccctc  cccttgtct  tgaatactt  gacaaggac  tgaagcagt  cctggatga  1140
tgtggaaat  tcatcaaca  gcacaatgt  aaactgttc  tgttccagt  gctccgtgg  1200
ctggcctac  gccacaggc  gaaggtgct  caccgagac  tcaagcccc  gaacctact  1260
atcaacgag  ggggagagc  caaactggc  gactttggc  tggcttacg  caagtcaat  1320
cctactaaa  catactcca  cgaagtggt  acactgtgg  accggcccc  tgacatctt  1380
cttgggtcc  cagactact  cggccaaat  gacatgtgg  gtgttggct  catctttta  1440
gagatggcc  caggccggc  cctcttccc  ggctccaca  tggaagaac  gctgcactt  1500
atcttccgc  ttttgggaa  cccaactga  gacacatgg  caggtatcc  gtccaatga  1560
gagtttaga  catacaact  ccccaagta  cgagccgag  cccttctga  gcatgcacc  1620
cgacttgaa  gcgatggag  tgacctcct  accaagctg  tgcagtttg  gggtcgcaa  1680
cggatctct  ctgaggatg  catgaaaca  ccattcttt  tcagcttgg  ggagcggat  1740
cacaaactt  ctgacacta  ttccatatt  gcactaaag  aggtacagc  acaaaagga  1800
gccaacatt  ggtccactt  tatgcctga  tcaggcagg  cagctttcc  tgtggtgga  1860
accgagttc  aagccaagt  ttaagccac  gacagacca  ggccccagc  ggcagcggc  1920
ggagggatg  cacacccct  acaggacag  ccccatctg  aatcctccc  gcttgttgc  1980
tgcttacct  cctgagcca  actcccctg  caacttgtc  cctgccacc  gtccaaaca  2040
cgaactact  gcctggcct  tcaacccaa  cactggcct  tctgctggg  gctaacaaa  2100
ctctcacca  tactttgct  gatgtgtct  tctctgtct  ggtagatgc  ggtggaccg  2160
atggccgtg  cagctttcc  cactaaggc  aggccttcc  ctcttcatc  cactctctc  2220
caggaccac  accccatgg  cagccaggg  tttggagct  gcccaggcc  ggctcttaa  2280
cgactttga  tagaaggta  tgagtgatg  cttgggtct  agcatcatt  gcctgcttc  2340
cacctgtcc  acttgcctc  gttgtatgg  ctttttttt  gtttctttt  ttgtttttt  2400
attatttta  atgaggttc  cacttttta  tgcaatatc  ctgtataca  actggttgg  2460
cactactcc  tgagtgtgg  actcccaca  tattttgtg  aatgaagtc  cactcccac  2520
ctttgagag  tagggaccc  gaccctatt  agatcctca  catcactag  ccctggaat  2580
ggctatggg  aagcatgcc  cagccactc  ccttcctcc  ctacctagc  ttcccagct  2640
tagggggac  tgagaacta  cagagagtg  gagatggac  tggtggggc  tactttttc  2700
ctccttcag  cccgtagcc  gggcctcct  ccttctcag  gtcttcccc  gcccagctc  2760
gcctagccc  cctgccctg  cctactcgg  gctgttgag  aggggctct  cctggaatc  2820
agcagctta  tgaggagcc  tatataata  gtgcacaag  aggaggaca  gtgggagct  2880
gtgcccaat  gttacaccc  aatccctag  agggtcagg  aggccaagg  cagtctcct  2940
gatggatgg  ttgctcccc  tactccacc  taagccttg  gacccttaa  cagggtggg  3000
gggcaaggg  gggtgccct  ctagtgggg  ttgggggga  tgggttcct  aatgcacca  3060
aatcgctgt  tgaaatatt  aaaaaaagt  taaagtgaa  aaaaaaaaa  a  3111



<210> 8468
<211> 462
<212> PRT
<213> Rattus norvegicus
<308> U36444
<400> 8468

Met Tyr Thr Asn Gly Tyr Asp Glu Glu Ile Tyr Tyr Ile Gly Gly Lys 
  1               5                  10                  15
Arg Val Phe Leu Thr Pro Lys Ala Trp Pro Phe Pro His Ser Ala Pro 
             20                  25                  30
Glu Ile Val His Glu Asp Met Lys Met Gly Ser Asp Gly Glu Ser Asp 
         35                  40                  45
Gln Ala Ser Ala Thr Ser Ser Asp Glu Val Gln Ser Pro Val Arg Val 
     50                  55                  60
Arg Met Arg Asn His Pro Pro Arg Lys Ile Ser Thr Glu Asp Ile Asn 
 65                  70                  75                  80
Lys Cys Leu Ser Leu Pro Ala Asp Ile Arg Leu Pro Glu Gly Tyr Leu 
                 85                  90                  95
Glu Lys Leu Thr Leu Asn Ser Pro Ile Gly Asp Lys Pro Leu Ser Arg 
             100                105                110
Arg Leu Arg Pro Val Ser Leu Ser Glu Ile Gly Phe Gly Lys Leu Glu 
         115                120                125
Thr Tyr Ile Lys Leu Asp Lys Leu Gly Glu Gly Thr Tyr Ala Thr Val 
     130                135                140
Tyr Lys Gly Lys Ser Lys Leu Thr Asp Asn Leu Val Ala Leu Lys Glu 
 145                150                155                160
Ile Arg Leu Glu His Glu Glu Gly Ala Pro Cys Thr Ala Ile Arg Glu 
                 165                170                175
Val Ser Leu Leu Lys Asp Leu Lys His Ala Asn Ile Val Thr Leu His 
             180                185                190
Asp Ile Ile His Thr Glu Lys Ser Leu Thr Leu Val Phe Glu Tyr Leu 
         195                200                205
Asp Lys Asp Leu Lys Gln Tyr Leu Asp Asp Cys Gly Asn Val Ile Asn 
     210                215                220
Met His Asn Val Lys Leu Phe Leu Phe Gln Leu Leu Arg Gly Leu Ala 
 225                230                235                240
Tyr Cys His Arg Gln Lys Val Leu His Arg Asp Leu Lys Pro Gln Asn 
                 245                250                255
Leu Leu Ile Asn Glu Arg Gly Glu Leu Lys Leu Ala Asp Phe Gly Leu 
             260                265                270
Ala Tyr Ala Lys Ser Ile Pro Thr Lys Thr Tyr Ser Asn Glu Val Val 
         275                280                285
Thr Leu Trp Tyr Arg Pro Pro Asp Ile Leu Leu Gly Ser Thr Asp Tyr 
     290                295                300
Ser Gly Gln Ile Asp Met Trp Gly Val Gly Cys Ile Phe Tyr Glu Met 
 305                310                315                320
Ala Thr Gly Arg Pro Leu Phe Pro Gly Ser Thr Val Glu Glu Gln Leu 
                 325                330                335
His Phe Ile Phe Arg Ile Leu Gly Thr Pro Thr Glu Asp Thr Trp Pro 
             340                345                350
Gly Ile Leu Ser Asn Glu Glu Phe Arg Thr Tyr Asn Tyr Pro Lys Tyr 
         355                360                365
Arg Ala Glu Ala Leu Leu Arg His Ala Pro Arg Leu Glu Cys Asp Gly 
     370                375                380
Ala Asp Leu Leu Thr Lys Leu Leu Gln Phe Glu Gly Arg Asn Arg Ile 
 385                390                395                400
Ser Ala Glu Asp Ala Met Lys His Pro Phe Phe Leu Ser Leu Gly Glu 
                 405                410                415
Arg Ile His Lys Leu Pro Asp Thr Thr Ser Ile Phe Ala Leu Lys Glu 
             420                425                430
Val Gln Leu Gln Lys Glu Ala Asn Ile Arg Ser Thr Ser Met Pro Asp 
         435                440                445
Ser Gly Arg Pro Ala Phe Arg Val Val Asp Thr Glu Phe Ter 
     450                455                460



<210> 8469
<211> 3131
<212> DNA
<213> Homo sapiens
<308> NM_006201
<400> 8469

gcggagcgc  gcgcgcgcg  cggttgggc  gttggctgt  cggccctgg  atccgccgc  60
actccgcga  cagaccgct  tgtgccgcg  gccgccgtg  gcactcgga  tcaagccgg  120
gccaacgag  ccgggggca  cgcccgcag  ggccaagct  atggccggc  gagcgggac  180
ccgcctccg  ctcagccac  gccgccgcc  ccgcctcct  ctcctcagc  ggcggcggc  240
cgggcccag  aaccatggc  gaagactac  gggacgggc  cctgcggcg  acaggagga  300
aaggaggtc  cgcggcctc  tcccgggcc  ccgccccag  cgccgccgc  ccggccccg  360
ggctctgag  ttgctcgcg  gcccccgcc  atcgccatg  atcggatga  gaagatcaa  420
cggcagctg  caatgacac  ccgaggtgg  cgaggcata  acaagacca  tggtgcccc  480
gagcagata  gcctggatg  gagtggtgg  ggtggcggc  gtgaccctg  agaggcccc  540
acacgtgct  ctcctgggg  acttcgttc  gcacggggc  cactcagct  tgcaccaga  600
attgtgcac  aggacttga  gatggggtc  gatggggag  gtgaccagg  ttcagccac  660
tcctcggat  aggtgcagt  tccagtgag  gtgcgtatg  gcaaccatc  cccacgcaa  720
atctccact  aggacatca  caagcgcct  tcactacca  ctgacatcc  gctgcctga  780
ggctacctg  agaagctga  cctcaatag  cccatcttt  acaagcccc  cagccgccg  840
ctccgtcgt  tcagcctat  tgagattgg  tttgggaaa  tggagacct  cattaagct  900
gacaaactg  gcgagggta  ctatgccac  gtctacaaa  gcaaaagca  gctcacaga  960
aaccttgtg  cactcaagg  gatcagact  gaacatgaa  agggggcac  ctgcaccgc  1020
atccgggaa  tgtccctgc  caaggacct  aaacacgcc  acatcgtta  gctacatga  1080
attatccac  cggagaagt  cctcaccct  gtctttgag  acctggaca  ggacctgaa  1140
cagtacctg  atgactgtg  gaacatcat  aacatgcac  acgtgaaac  gttcctgtt  1200
cagctgctc  gtggcctgg  ctactgcca  cggcagaag  tgctacacc  agacctcaa  1260
ccccagaac  tgctcatca  cgagagggg  gagctcaag  tggctgact  tggcctggc  1320
cgagccaag  caatcccaa  aaagacata  tccaatgag  tggtgacac  gtggtaccg  1380
ccccctgac  tcctgcttg  gtccacgga  tactccact  agattgaca  gtggggtgt  1440
ggctgcatc  tctatgaga  ggccacagg  cgtcccctc  ttccgggct  cacggtgga  1500
gaacagcta  acttcatct  ccgtatctt  ggaacccca  ctgaggaga  gtggccagg  1560
atcctgtcc  acgaggagt  caagacata  aactacccc  agtaccgag  cgaggccct  1620
ttgagccac  caccccgac  tgatagcga  ggggccgac  tcctcacca  gctgttgca  1680
tttgagggt  gaaatcgga  ctccgcaga  gatgccatg  aacatccat  cttcctcag  1740
ctgggggag  ggatccaca  acttcctga  actacttcc  tatttgcac  aaaggagat  1800
cagctacaa  aggaggcca  ccttcggtc  tcgtcgatg  ctgactcag  caggccagc  1860
ttccgcgtg  tggacaccg  gttctaagc  acagaccga  gccccagca  gcagcggct  1920
gagggatgc  acacccctc  cagggcagc  cccaactac  tcttccctg  ttactctct  1980
cctacctgc  tgagccatg  tcacctgcc  acttgtccc  tgctgcctg  ccaaacacc  2040
caccattgg  ctgtcaacc  acccattgg  ctgtctgct  ggtgctaac  aagctctca  2100
cactccttc  cttggtctg  ctgtctctg  cttggtagt  gccggtgga  agcatggcc  2160
tgccagcct  ccacactga  gccaggtct  ccccccatc  taccagccc  caggaccac  2220
accccacgg  cagccaggg  tccagagct  gcccaggct  gggatctcg  ctcagacaa  2280
atggtgaca  tgccttgag  ctgaggcat  ctctgcctg  tttcctgcc  gccccacct  2340
cctcatatt  tgtgggcct  tttttgttt  tttcattca  tgttttttt  ttttttaat  2400
attttaaat  agatttttg  tttttttaa  tgcaatatc  ctgtataca  actggctgg  2460
ccccacccc  tgcgtgtgg  cctcccaca  tattttgtg  aatgaagcc  tgctcccag  2520
ctttcagag  cagggacac  gcccctatt  ggaaccctg  tcatcacca  accctggga  2580
tggctatgg  aaagcatgc  acagccact  gccttccta  ccccgcccg  catccccag  2640
tgcaggggg  tctggggac  accagagac  ctgggaaat  gacaaggtg  ggggcccca  2700
tctttctct  ctgcagtcc  gtagctggg  cctccttcc  tctcagggt  tccccagcc  2760
agtcccctt  ctcccatcc  actcggtgc  gttgggtag  ggccctgcc  ggaactgac  2820
agctcagcg  ggagccata  tgtgcatat  tgcacaagc  gggttgggg  aggggggtg  2880
gaggggttg  gcccaggtg  tgcccccta  ctcctgggg  gggtgaggc  gggcaggga  2940
agtctccag  gtcagtccc  ggatgggtg  ttacctccc  ttcctccac  ctaagccct  3000
gggccctga  atggggtgg  agggcaggg  tgggagccc  cctagtggg  ttggggggt  3060
gggttcctg  atgcaccat  atcgctgta  gaaatatta  aaagtctaa  gtgaaaaaa  3120
aaaaaaaaa  a  3131



<210> 8470
<211> 496
<212> PRT
<213> Homo sapiens
<308> Q00536
<400> 8470

Met Asp Arg Met Lys Lys Ile Lys Arg Gln Leu Ser Met Thr Leu Arg 
  1               5                  10                  15
Gly Gly Arg Gly Ile Asp Lys Thr Asn Gly Ala Pro Glu Gln Ile Gly 
             20                  25                  30
Leu Asp Glu Ser Gly Gly Gly Gly Gly Ser Asp Pro Gly Glu Ala Pro 
         35                  40                  45
Thr Arg Ala Ala Pro Gly Glu Leu Arg Ser Ala Arg Gly Pro Leu Ser 
     50                  55                  60
Ser Ala Pro Glu Ile Val His Glu Asp Leu Lys Met Gly Ser Asp Gly 
 65                  70                  75                  80
Glu Ser Asp Gln Ala Ser Ala Thr Ser Ser Asp Glu Val Gln Ser Pro 
                 85                  90                  95
Val Arg Val Arg Met Arg Asn His Pro Pro Arg Lys Ile Ser Thr Glu 
             100                105                110
Asp Ile Asn Lys Arg Leu Ser Leu Pro Ala Asp Ile Arg Leu Pro Glu 
         115                120                125
Gly Tyr Leu Glu Lys Leu Thr Leu Asn Ser Pro Ile Phe Asp Lys Pro 
     130                135                140
Leu Ser Arg Arg Leu Arg Arg Val Ser Leu Ser Glu Ile Gly Phe Gly 
 145                150                155                160
Lys Leu Glu Thr Tyr Ile Lys Leu Asp Lys Leu Gly Glu Gly Thr Tyr 
                 165                170                175
Ala Thr Val Tyr Lys Gly Lys Ser Lys Leu Thr Asp Asn Leu Val Ala 
             180                185                190
Leu Lys Glu Ile Arg Leu Glu His Glu Glu Gly Ala Pro Cys Thr Ala 
         195                200                205
Ile Arg Glu Val Ser Leu Leu Lys Asp Leu Lys His Ala Asn Ile Val 
     210                215                220
Thr Leu His Asp Ile Ile His Thr Glu Lys Ser Leu Thr Leu Val Phe 
 225                230                235                240
Glu Tyr Leu Asp Lys Asp Leu Lys Gln Tyr Leu Asp Asp Cys Gly Asn 
                 245                250                255
Ile Ile Asn Met His Asn Val Lys Leu Phe Leu Phe Gln Leu Leu Arg 
             260                265                270
Gly Leu Ala Tyr Cys His Arg Gln Lys Val Leu His Arg Asp Leu Lys 
         275                280                285
Pro Gln Asn Leu Leu Ile Asn Glu Arg Gly Glu Leu Lys Leu Ala Asp 
     290                295                300
Phe Gly Leu Ala Arg Ala Lys Ser Ile Pro Thr Lys Thr Tyr Ser Asn 
 305                310                315                320
Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Ile Leu Leu Gly Ser 
                 325                330                335
Thr Asp Tyr Ser Thr Gln Ile Asp Met Trp Gly Val Gly Cys Ile Phe 
             340                345                350
Tyr Glu Met Ala Thr Gly Arg Pro Leu Phe Pro Gly Ser Thr Val Glu 
         355                360                365
Glu Gln Leu His Phe Ile Phe Arg Ile Leu Gly Thr Pro Thr Glu Glu 
     370                375                380
Thr Trp Pro Gly Ile Leu Ser Asn Glu Glu Phe Lys Thr Tyr Asn Tyr 
 385                390                395                400
Pro Lys Tyr Arg Ala Glu Ala Leu Leu Ser His Ala Pro Arg Leu Asp 
                 405                410                415
Ser Asp Gly Ala Asp Leu Leu Thr Lys Leu Leu Gln Phe Glu Gly Arg 
             420                425                430
Asn Arg Ile Ser Ala Glu Asp Ala Met Lys His Pro Phe Phe Leu Ser 
         435                440                445
Leu Gly Glu Arg Ile His Lys Leu Pro Asp Thr Thr Ser Ile Phe Ala 
     450                455                460
Leu Lys Glu Ile Gln Leu Gln Lys Glu Ala Ser Leu Arg Ser Ser Ser 
 465                470                475                480
Met Pro Asp Ser Gly Arg Pro Ala Phe Arg Val Val Asp Thr Glu Phe 
                 485                490                495



<210> 8471
<211> 1139
<212> DNA
<213> Rattus norvegicus
<308> U36482
<400> 8471

cctgctgta  cttgcccat  tcccgctcc  acaatccgg  gtgatggct  ccgccgttc  60
tggcgccgt  tcgctctcc  cactgctgt  cgttctcct  ggcctgctg  tcctctctg  120
tcctcatgg  gccagcggc  tgcacacga  gggcgccct  cccttggac  cagtcactt  180
ctacaaggt  attcccaaa  gcaagttcg  cttggtgaa  ttcgacacc  agtacccct  240
tggagagaa  caagatgag  ttaagcgtc  ggctgagaa  tcagcctcc  gcgatgatc  300
cttggtggc  gaggtgggg  tctcagact  tggtgacaa  ctgaacatg  agctgagtg  360
gaagtacaa  ctggacaaa  agagctacc  agtcttcta  ctcttccgg  atggggact  420
tgagaatcc  gtcccatac  gcggggcag  taaagttgg  gccatccag  gctggctca  480
ggggcaggg  gtctatctg  gcatgcctg  atgtctgcc  gcgtacgat  ccctggcgg  540
ccagttcat  gaggcctcc  gcagagagg  ccgccaggc  atcctgaaa  aggggcagg  600
tggcctctc  ggtgtgaag  agacagaca  gaagtgggc  agtcagtac  tgaagatca  660
ggggaagat  ttggaccaa  gtgaagact  cccggcctc  gagctggcc  ggatcagta  720
gctcattga  aacaagatg  gtgagggta  gaaggaaga  ctgcagagg  gcctcaaca  780
cctcaccgc  ttccgcaag  aaggcgccg  gaaggagga  ctgtgaggg  accaggctg  840
tagggtttg  tgagggcgg  gagggagag  cgcctgctg  ctgtggggc  ctgtgggtg  900
agggggcag  ggagcaaag  agtcctgag  cagagacct  tgccccgag  gcctggaca  960
tgaggctgc  gagaccata  cctggacat  cttggtgca  tttgtgggg  gcctgtgtg  1020
caagacaag  tggctgtgt  cccacagga  ctggtacta  agaggaagg  ccttgacag  1080
tatagttct  atcaaataa  agtctgttt  gggttaaaa  aaaaaaaaa  aaaaaaaaa  1139



<210> 8472
<211> 260
<212> PRT
<213> Rattus norvegicus
<308> P52555
<400> 8472

Met Ala Ala Ala Val Pro Gly Ala Val Ser Leu Ser Pro Leu Leu Ser 
  1               5                  10                  15
Val Leu Leu Gly Leu Leu Leu Leu Ser Ala Pro His Gly Ala Ser Gly 
             20                  25                  30
Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys 
         35                  40                  45
Val Ile Pro Lys Ser Lys Phe Val Leu Val Lys Phe Asp Thr Gln Tyr 
     50                  55                  60
Pro Tyr Gly Glu Lys Gln Asp Glu Phe Lys Arg Leu Ala Glu Asn Ser 
 65                  70                  75                  80
Ala Ser Ser Asp Asp Leu Leu Val Ala Glu Val Gly Ile Ser Asp Tyr 
                 85                  90                  95
Gly Asp Lys Leu Asn Met Glu Leu Ser Glu Lys Tyr Lys Leu Asp Lys 
             100                105                110
Glu Ser Tyr Pro Val Phe Tyr Leu Phe Arg Asp Gly Asp Phe Glu Asn 
         115                120                125
Pro Val Pro Tyr Ser Gly Ala Val Lys Val Gly Ala Ile Gln Arg Trp 
     130                135                140
Leu Lys Gly Gln Gly Val Tyr Leu Gly Met Pro Gly Cys Leu Pro Ala 
 145                150                155                160
Tyr Asp Ala Leu Ala Gly Gln Phe Ile Glu Ala Ser Ser Arg Glu Ala 
                 165                170                175
Arg Gln Ala Ile Leu Lys Gln Gly Gln Asp Gly Leu Ser Gly Val Lys 
             180                185                190
Glu Thr Asp Lys Lys Trp Ala Ser Gln Tyr Leu Lys Ile Met Gly Lys 
         195                200                205
Ile Leu Asp Gln Gly Glu Asp Phe Pro Ala Ser Glu Leu Ala Arg Ile 
     210                215                220
Ser Lys Leu Ile Glu Asn Lys Met Ser Glu Gly Lys Lys Glu Glu Leu 
 225                230                235                240
Gln Arg Ser Leu Asn Ile Leu Thr Ala Phe Arg Lys Lys Gly Ala Glu 
                 245                250                255
Lys Glu Glu Leu 
             260



<210> 8473
<211> 892
<212> DNA
<213> Homo sapiens
<308> X94910
<400> 8473

cggccggcg  tatggctgc  gctgtgccc  gcgccgcat  tctctcccc  ctgcttccc  60
ttctcctgg  cttcctgct  ctctccgct  cgcatggcg  cagcggcct  cacaccaag  120
gcgcccttc  cctggatac  gtcactttc  acaaggtca  tcccaaaag  aagttcgtc  180
tggtgaagt  cgacaccca  tacccctac  gtgagaagc  ggatgagtt  aagcgtctt  240
ctgaaaact  ggcttccag  gatgatctc  tggtggcag  ggtggggat  tcagattat  300
gtgacaagc  gaacatgga  ctgagtgag  aatacaagc  ggacaaaga  agctaccca  360
tcttctacc  cttccggga  ggggacttt  agaacccag  cccatacac  ggggcagtt  420
aggttggag  catccagcg  tggctgaag  ggcaagggg  ctacctagg  atgcctggt  480
gcctgcctg  atacgacgc  ctggccggg  agttcatca  ggcctctgg  gtggaggcc  540
gccaggccc  cttgaagca  gggcaagat  acctctcaa  tgtgaagga  actcagaag  600
agtgggccg  gcaatacct  aagatcatg  ggaagatct  agaccaagg  gaggacttc  660
cagcatcag  gatgacacg  atcgccagg  tgattgaga  gaacaagat  agtgacggc  720
agaaggagg  gctccagaa  agcttaaac  tcctgactg  cttccagaa  aagggggcc  780
agaaagagg  gctgtaaaa  ggctgtctg  gattttcca  ggtttggtg  gggtaggga  840
gggagagtt  acctgctgg  tgtgagtcc  ttgtggaat  taagggggc  cg  892



<210> 8474
<211> 261
<212> PRT
<213> Homo sapiens
<308> P30040
<400> 8474

Met Ala Ala Ala Val Pro Arg Ala Ala Phe Leu Ser Pro Leu Leu Pro 
  1               5                  10                  15
Leu Leu Leu Gly Phe Leu Leu Leu Ser Ala Pro His Gly Gly Ser Gly 
             20                  25                  30
Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys 
         35                  40                  45
Val Ile Pro Lys Ser Lys Phe Val Leu Val Lys Phe Asp Thr Gln Tyr 
     50                  55                  60
Pro Tyr Gly Glu Lys Gln Asp Glu Phe Lys Arg Leu Ala Glu Asn Ser 
 65                  70                  75                  80
Ala Ser Ser Asp Asp Leu Leu Val Ala Glu Val Gly Ile Ser Asp Tyr 
                 85                  90                  95
Gly Asp Lys Leu Asn Met Glu Leu Ser Glu Lys Tyr Lys Leu Asp Lys 
             100                105                110
Glu Ser Tyr Pro Val Phe Tyr Leu Phe Arg Asp Gly Asp Phe Glu Asn 
         115                120                125
Pro Val Pro Tyr Thr Gly Ala Val Lys Val Gly Ala Ile Gln Arg Trp 
     130                135                140
Leu Lys Gly Gln Gly Val Tyr Leu Gly Met Pro Gly Cys Leu Pro Val 
 145                150                155                160
Tyr Asp Ala Leu Ala Gly Glu Phe Ile Arg Ala Ser Gly Val Glu Ala 
                 165                170                175
Arg Gln Ala Leu Leu Lys Gln Gly Gln Asp Asn Leu Ser Ser Val Lys 
             180                185                190
Glu Thr Gln Lys Lys Trp Ala Glu Gln Tyr Leu Lys Ile Met Gly Lys 
         195                200                205
Ile Leu Asp Gln Gly Glu Asp Phe Pro Ala Ser Glu Met Thr Arg Ile 
     210                215                220
Ala Arg Leu Ile Glu Lys Asn Lys Met Ser Asp Gly Lys Lys Glu Glu 
 225                230                235                240
Leu Gln Lys Ser Leu Asn Ile Leu Thr Ala Phe Gln Lys Lys Gly Ala 
                 245                250                255
Glu Lys Glu Glu Leu 
             260



<210> 8475
<211> 1139
<212> DNA
<213> Rattus norvegicus
<308> U36482
<400> 8475

cctgctgta  cttgcccat  tcccgctcc  acaatccgg  gtgatggct  ccgccgttc  60
tggcgccgt  tcgctctcc  cactgctgt  cgttctcct  ggcctgctg  tcctctctg  120
tcctcatgg  gccagcggc  tgcacacga  gggcgccct  cccttggac  cagtcactt  180
ctacaaggt  attcccaaa  gcaagttcg  cttggtgaa  ttcgacacc  agtacccct  240
tggagagaa  caagatgag  ttaagcgtc  ggctgagaa  tcagcctcc  gcgatgatc  300
cttggtggc  gaggtgggg  tctcagact  tggtgacaa  ctgaacatg  agctgagtg  360
gaagtacaa  ctggacaaa  agagctacc  agtcttcta  ctcttccgg  atggggact  420
tgagaatcc  gtcccatac  gcggggcag  taaagttgg  gccatccag  gctggctca  480
ggggcaggg  gtctatctg  gcatgcctg  atgtctgcc  gcgtacgat  ccctggcgg  540
ccagttcat  gaggcctcc  gcagagagg  ccgccaggc  atcctgaaa  aggggcagg  600
tggcctctc  ggtgtgaag  agacagaca  gaagtgggc  agtcagtac  tgaagatca  660
ggggaagat  ttggaccaa  gtgaagact  cccggcctc  gagctggcc  ggatcagta  720
gctcattga  aacaagatg  gtgagggta  gaaggaaga  ctgcagagg  gcctcaaca  780
cctcaccgc  ttccgcaag  aaggcgccg  gaaggagga  ctgtgaggg  accaggctg  840
tagggtttg  tgagggcgg  gagggagag  cgcctgctg  ctgtggggc  ctgtgggtg  900
agggggcag  ggagcaaag  agtcctgag  cagagacct  tgccccgag  gcctggaca  960
tgaggctgc  gagaccata  cctggacat  cttggtgca  tttgtgggg  gcctgtgtg  1020
caagacaag  tggctgtgt  cccacagga  ctggtacta  agaggaagg  ccttgacag  1080
tatagttct  atcaaataa  agtctgttt  gggttaaaa  aaaaaaaaa  aaaaaaaaa  1139



<210> 8476
<211> 260
<212> PRT
<213> Rattus norvegicus
<308> P52555
<400> 8476

Met Ala Ala Ala Val Pro Gly Ala Val Ser Leu Ser Pro Leu Leu Ser 
  1               5                  10                  15
Val Leu Leu Gly Leu Leu Leu Leu Ser Ala Pro His Gly Ala Ser Gly 
             20                  25                  30
Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys 
         35                  40                  45
Val Ile Pro Lys Ser Lys Phe Val Leu Val Lys Phe Asp Thr Gln Tyr 
     50                  55                  60
Pro Tyr Gly Glu Lys Gln Asp Glu Phe Lys Arg Leu Ala Glu Asn Ser 
 65                  70                  75                  80
Ala Ser Ser Asp Asp Leu Leu Val Ala Glu Val Gly Ile Ser Asp Tyr 
                 85                  90                  95
Gly Asp Lys Leu Asn Met Glu Leu Ser Glu Lys Tyr Lys Leu Asp Lys 
             100                105                110
Glu Ser Tyr Pro Val Phe Tyr Leu Phe Arg Asp Gly Asp Phe Glu Asn 
         115                120                125
Pro Val Pro Tyr Ser Gly Ala Val Lys Val Gly Ala Ile Gln Arg Trp 
     130                135                140
Leu Lys Gly Gln Gly Val Tyr Leu Gly Met Pro Gly Cys Leu Pro Ala 
 145                150                155                160
Tyr Asp Ala Leu Ala Gly Gln Phe Ile Glu Ala Ser Ser Arg Glu Ala 
                 165                170                175
Arg Gln Ala Ile Leu Lys Gln Gly Gln Asp Gly Leu Ser Gly Val Lys 
             180                185                190
Glu Thr Asp Lys Lys Trp Ala Ser Gln Tyr Leu Lys Ile Met Gly Lys 
         195                200                205
Ile Leu Asp Gln Gly Glu Asp Phe Pro Ala Ser Glu Leu Ala Arg Ile 
     210                215                220
Ser Lys Leu Ile Glu Asn Lys Met Ser Glu Gly Lys Lys Glu Glu Leu 
 225                230                235                240
Gln Arg Ser Leu Asn Ile Leu Thr Ala Phe Arg Lys Lys Gly Ala Glu 
                 245                250                255
Lys Glu Glu Leu 
             260



<210> 8477
<211> 892
<212> DNA
<213> Homo sapiens
<308> X94910
<400> 8477

cggccggcg  tatggctgc  gctgtgccc  gcgccgcat  tctctcccc  ctgcttccc  60
ttctcctgg  cttcctgct  ctctccgct  cgcatggcg  cagcggcct  cacaccaag  120
gcgcccttc  cctggatac  gtcactttc  acaaggtca  tcccaaaag  aagttcgtc  180
tggtgaagt  cgacaccca  tacccctac  gtgagaagc  ggatgagtt  aagcgtctt  240
ctgaaaact  ggcttccag  gatgatctc  tggtggcag  ggtggggat  tcagattat  300
gtgacaagc  gaacatgga  ctgagtgag  aatacaagc  ggacaaaga  agctaccca  360
tcttctacc  cttccggga  ggggacttt  agaacccag  cccatacac  ggggcagtt  420
aggttggag  catccagcg  tggctgaag  ggcaagggg  ctacctagg  atgcctggt  480
gcctgcctg  atacgacgc  ctggccggg  agttcatca  ggcctctgg  gtggaggcc  540
gccaggccc  cttgaagca  gggcaagat  acctctcaa  tgtgaagga  actcagaag  600
agtgggccg  gcaatacct  aagatcatg  ggaagatct  agaccaagg  gaggacttc  660
cagcatcag  gatgacacg  atcgccagg  tgattgaga  gaacaagat  agtgacggc  720
agaaggagg  gctccagaa  agcttaaac  tcctgactg  cttccagaa  aagggggcc  780
agaaagagg  gctgtaaaa  ggctgtctg  gattttcca  ggtttggtg  gggtaggga  840
gggagagtt  acctgctgg  tgtgagtcc  ttgtggaat  taagggggc  cg  892



<210> 8478
<211> 261
<212> PRT
<213> Homo sapiens
<308> P30040
<400> 8478

Met Ala Ala Ala Val Pro Arg Ala Ala Phe Leu Ser Pro Leu Leu Pro 
  1               5                  10                  15
Leu Leu Leu Gly Phe Leu Leu Leu Ser Ala Pro His Gly Gly Ser Gly 
             20                  25                  30
Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys 
         35                  40                  45
Val Ile Pro Lys Ser Lys Phe Val Leu Val Lys Phe Asp Thr Gln Tyr 
     50                  55                  60
Pro Tyr Gly Glu Lys Gln Asp Glu Phe Lys Arg Leu Ala Glu Asn Ser 
 65                  70                  75                  80
Ala Ser Ser Asp Asp Leu Leu Val Ala Glu Val Gly Ile Ser Asp Tyr 
                 85                  90                  95
Gly Asp Lys Leu Asn Met Glu Leu Ser Glu Lys Tyr Lys Leu Asp Lys 
             100                105                110
Glu Ser Tyr Pro Val Phe Tyr Leu Phe Arg Asp Gly Asp Phe Glu Asn 
         115                120                125
Pro Val Pro Tyr Thr Gly Ala Val Lys Val Gly Ala Ile Gln Arg Trp 
     130                135                140
Leu Lys Gly Gln Gly Val Tyr Leu Gly Met Pro Gly Cys Leu Pro Val 
 145                150                155                160
Tyr Asp Ala Leu Ala Gly Glu Phe Ile Arg Ala Ser Gly Val Glu Ala 
                 165                170                175
Arg Gln Ala Leu Leu Lys Gln Gly Gln Asp Asn Leu Ser Ser Val Lys 
             180                185                190
Glu Thr Gln Lys Lys Trp Ala Glu Gln Tyr Leu Lys Ile Met Gly Lys 
         195                200                205
Ile Leu Asp Gln Gly Glu Asp Phe Pro Ala Ser Glu Met Thr Arg Ile 
     210                215                220
Ala Arg Leu Ile Glu Lys Asn Lys Met Ser Asp Gly Lys Lys Glu Glu 
 225                230                235                240
Leu Gln Lys Ser Leu Asn Ile Leu Thr Ala Phe Gln Lys Lys Gly Ala 
                 245                250                255
Glu Lys Glu Glu Leu 
             260



<210> 8479
<211> 1139
<212> DNA
<213> Rattus norvegicus
<308> U36482
<400> 8479

cctgctgta  cttgcccat  tcccgctcc  acaatccgg  gtgatggct  ccgccgttc  60
tggcgccgt  tcgctctcc  cactgctgt  cgttctcct  ggcctgctg  tcctctctg  120
tcctcatgg  gccagcggc  tgcacacga  gggcgccct  cccttggac  cagtcactt  180
ctacaaggt  attcccaaa  gcaagttcg  cttggtgaa  ttcgacacc  agtacccct  240
tggagagaa  caagatgag  ttaagcgtc  ggctgagaa  tcagcctcc  gcgatgatc  300
cttggtggc  gaggtgggg  tctcagact  tggtgacaa  ctgaacatg  agctgagtg  360
gaagtacaa  ctggacaaa  agagctacc  agtcttcta  ctcttccgg  atggggact  420
tgagaatcc  gtcccatac  gcggggcag  taaagttgg  gccatccag  gctggctca  480
ggggcaggg  gtctatctg  gcatgcctg  atgtctgcc  gcgtacgat  ccctggcgg  540
ccagttcat  gaggcctcc  gcagagagg  ccgccaggc  atcctgaaa  aggggcagg  600
tggcctctc  ggtgtgaag  agacagaca  gaagtgggc  agtcagtac  tgaagatca  660
ggggaagat  ttggaccaa  gtgaagact  cccggcctc  gagctggcc  ggatcagta  720
gctcattga  aacaagatg  gtgagggta  gaaggaaga  ctgcagagg  gcctcaaca  780
cctcaccgc  ttccgcaag  aaggcgccg  gaaggagga  ctgtgaggg  accaggctg  840
tagggtttg  tgagggcgg  gagggagag  cgcctgctg  ctgtggggc  ctgtgggtg  900
agggggcag  ggagcaaag  agtcctgag  cagagacct  tgccccgag  gcctggaca  960
tgaggctgc  gagaccata  cctggacat  cttggtgca  tttgtgggg  gcctgtgtg  1020
caagacaag  tggctgtgt  cccacagga  ctggtacta  agaggaagg  ccttgacag  1080
tatagttct  atcaaataa  agtctgttt  gggttaaaa  aaaaaaaaa  aaaaaaaaa  1139



<210> 8480
<211> 260
<212> PRT
<213> Rattus norvegicus
<308> P52555
<400> 8480

Met Ala Ala Ala Val Pro Gly Ala Val Ser Leu Ser Pro Leu Leu Ser 
  1               5                  10                  15
Val Leu Leu Gly Leu Leu Leu Leu Ser Ala Pro His Gly Ala Ser Gly 
             20                  25                  30
Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys 
         35                  40                  45
Val Ile Pro Lys Ser Lys Phe Val Leu Val Lys Phe Asp Thr Gln Tyr 
     50                  55                  60
Pro Tyr Gly Glu Lys Gln Asp Glu Phe Lys Arg Leu Ala Glu Asn Ser 
 65                  70                  75                  80
Ala Ser Ser Asp Asp Leu Leu Val Ala Glu Val Gly Ile Ser Asp Tyr 
                 85                  90                  95
Gly Asp Lys Leu Asn Met Glu Leu Ser Glu Lys Tyr Lys Leu Asp Lys 
             100                105                110
Glu Ser Tyr Pro Val Phe Tyr Leu Phe Arg Asp Gly Asp Phe Glu Asn 
         115                120                125
Pro Val Pro Tyr Ser Gly Ala Val Lys Val Gly Ala Ile Gln Arg Trp 
     130                135                140
Leu Lys Gly Gln Gly Val Tyr Leu Gly Met Pro Gly Cys Leu Pro Ala 
 145                150                155                160
Tyr Asp Ala Leu Ala Gly Gln Phe Ile Glu Ala Ser Ser Arg Glu Ala 
                 165                170                175
Arg Gln Ala Ile Leu Lys Gln Gly Gln Asp Gly Leu Ser Gly Val Lys 
             180                185                190
Glu Thr Asp Lys Lys Trp Ala Ser Gln Tyr Leu Lys Ile Met Gly Lys 
         195                200                205
Ile Leu Asp Gln Gly Glu Asp Phe Pro Ala Ser Glu Leu Ala Arg Ile 
     210                215                220
Ser Lys Leu Ile Glu Asn Lys Met Ser Glu Gly Lys Lys Glu Glu Leu 
 225                230                235                240
Gln Arg Ser Leu Asn Ile Leu Thr Ala Phe Arg Lys Lys Gly Ala Glu 
                 245                250                255
Lys Glu Glu Leu 
             260



<210> 8481
<211> 892
<212> DNA
<213> Homo sapiens
<308> X94910
<400> 8481

cggccggcg  tatggctgc  gctgtgccc  gcgccgcat  tctctcccc  ctgcttccc  60
ttctcctgg  cttcctgct  ctctccgct  cgcatggcg  cagcggcct  cacaccaag  120
gcgcccttc  cctggatac  gtcactttc  acaaggtca  tcccaaaag  aagttcgtc  180
tggtgaagt  cgacaccca  tacccctac  gtgagaagc  ggatgagtt  aagcgtctt  240
ctgaaaact  ggcttccag  gatgatctc  tggtggcag  ggtggggat  tcagattat  300
gtgacaagc  gaacatgga  ctgagtgag  aatacaagc  ggacaaaga  agctaccca  360
tcttctacc  cttccggga  ggggacttt  agaacccag  cccatacac  ggggcagtt  420
aggttggag  catccagcg  tggctgaag  ggcaagggg  ctacctagg  atgcctggt  480
gcctgcctg  atacgacgc  ctggccggg  agttcatca  ggcctctgg  gtggaggcc  540
gccaggccc  cttgaagca  gggcaagat  acctctcaa  tgtgaagga  actcagaag  600
agtgggccg  gcaatacct  aagatcatg  ggaagatct  agaccaagg  gaggacttc  660
cagcatcag  gatgacacg  atcgccagg  tgattgaga  gaacaagat  agtgacggc  720
agaaggagg  gctccagaa  agcttaaac  tcctgactg  cttccagaa  aagggggcc  780
agaaagagg  gctgtaaaa  ggctgtctg  gattttcca  ggtttggtg  gggtaggga  840
gggagagtt  acctgctgg  tgtgagtcc  ttgtggaat  taagggggc  cg  892



<210> 8482
<211> 261
<212> PRT
<213> Homo sapiens
<308> P30040
<400> 8482

Met Ala Ala Ala Val Pro Arg Ala Ala Phe Leu Ser Pro Leu Leu Pro 
  1               5                  10                  15
Leu Leu Leu Gly Phe Leu Leu Leu Ser Ala Pro His Gly Gly Ser Gly 
             20                  25                  30
Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys 
         35                  40                  45
Val Ile Pro Lys Ser Lys Phe Val Leu Val Lys Phe Asp Thr Gln Tyr 
     50                  55                  60
Pro Tyr Gly Glu Lys Gln Asp Glu Phe Lys Arg Leu Ala Glu Asn Ser 
 65                  70                  75                  80
Ala Ser Ser Asp Asp Leu Leu Val Ala Glu Val Gly Ile Ser Asp Tyr 
                 85                  90                  95
Gly Asp Lys Leu Asn Met Glu Leu Ser Glu Lys Tyr Lys Leu Asp Lys 
             100                105                110
Glu Ser Tyr Pro Val Phe Tyr Leu Phe Arg Asp Gly Asp Phe Glu Asn 
         115                120                125
Pro Val Pro Tyr Thr Gly Ala Val Lys Val Gly Ala Ile Gln Arg Trp 
     130                135                140
Leu Lys Gly Gln Gly Val Tyr Leu Gly Met Pro Gly Cys Leu Pro Val 
 145                150                155                160
Tyr Asp Ala Leu Ala Gly Glu Phe Ile Arg Ala Ser Gly Val Glu Ala 
                 165                170                175
Arg Gln Ala Leu Leu Lys Gln Gly Gln Asp Asn Leu Ser Ser Val Lys 
             180                185                190
Glu Thr Gln Lys Lys Trp Ala Glu Gln Tyr Leu Lys Ile Met Gly Lys 
         195                200                205
Ile Leu Asp Gln Gly Glu Asp Phe Pro Ala Ser Glu Met Thr Arg Ile 
     210                215                220
Ala Arg Leu Ile Glu Lys Asn Lys Met Ser Asp Gly Lys Lys Glu Glu 
 225                230                235                240
Leu Gln Lys Ser Leu Asn Ile Leu Thr Ala Phe Gln Lys Lys Gly Ala 
                 245                250                255
Glu Lys Glu Glu Leu 
             260



<210> 8483
<211> 1139
<212> DNA
<213> Rattus norvegicus
<308> U36482
<400> 8483

cctgctgta  cttgcccat  tcccgctcc  acaatccgg  gtgatggct  ccgccgttc  60
tggcgccgt  tcgctctcc  cactgctgt  cgttctcct  ggcctgctg  tcctctctg  120
tcctcatgg  gccagcggc  tgcacacga  gggcgccct  cccttggac  cagtcactt  180
ctacaaggt  attcccaaa  gcaagttcg  cttggtgaa  ttcgacacc  agtacccct  240
tggagagaa  caagatgag  ttaagcgtc  ggctgagaa  tcagcctcc  gcgatgatc  300
cttggtggc  gaggtgggg  tctcagact  tggtgacaa  ctgaacatg  agctgagtg  360
gaagtacaa  ctggacaaa  agagctacc  agtcttcta  ctcttccgg  atggggact  420
tgagaatcc  gtcccatac  gcggggcag  taaagttgg  gccatccag  gctggctca  480
ggggcaggg  gtctatctg  gcatgcctg  atgtctgcc  gcgtacgat  ccctggcgg  540
ccagttcat  gaggcctcc  gcagagagg  ccgccaggc  atcctgaaa  aggggcagg  600
tggcctctc  ggtgtgaag  agacagaca  gaagtgggc  agtcagtac  tgaagatca  660
ggggaagat  ttggaccaa  gtgaagact  cccggcctc  gagctggcc  ggatcagta  720
gctcattga  aacaagatg  gtgagggta  gaaggaaga  ctgcagagg  gcctcaaca  780
cctcaccgc  ttccgcaag  aaggcgccg  gaaggagga  ctgtgaggg  accaggctg  840
tagggtttg  tgagggcgg  gagggagag  cgcctgctg  ctgtggggc  ctgtgggtg  900
agggggcag  ggagcaaag  agtcctgag  cagagacct  tgccccgag  gcctggaca  960
tgaggctgc  gagaccata  cctggacat  cttggtgca  tttgtgggg  gcctgtgtg  1020
caagacaag  tggctgtgt  cccacagga  ctggtacta  agaggaagg  ccttgacag  1080
tatagttct  atcaaataa  agtctgttt  gggttaaaa  aaaaaaaaa  aaaaaaaaa  1139



<210> 8484
<211> 260
<212> PRT
<213> Rattus norvegicus
<308> P52555
<400> 8484

Met Ala Ala Ala Val Pro Gly Ala Val Ser Leu Ser Pro Leu Leu Ser 
  1               5                  10                  15
Val Leu Leu Gly Leu Leu Leu Leu Ser Ala Pro His Gly Ala Ser Gly 
             20                  25                  30
Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys 
         35                  40                  45
Val Ile Pro Lys Ser Lys Phe Val Leu Val Lys Phe Asp Thr Gln Tyr 
     50                  55                  60
Pro Tyr Gly Glu Lys Gln Asp Glu Phe Lys Arg Leu Ala Glu Asn Ser 
 65                  70                  75                  80
Ala Ser Ser Asp Asp Leu Leu Val Ala Glu Val Gly Ile Ser Asp Tyr 
                 85                  90                  95
Gly Asp Lys Leu Asn Met Glu Leu Ser Glu Lys Tyr Lys Leu Asp Lys 
             100                105                110
Glu Ser Tyr Pro Val Phe Tyr Leu Phe Arg Asp Gly Asp Phe Glu Asn 
         115                120                125
Pro Val Pro Tyr Ser Gly Ala Val Lys Val Gly Ala Ile Gln Arg Trp 
     130                135                140
Leu Lys Gly Gln Gly Val Tyr Leu Gly Met Pro Gly Cys Leu Pro Ala 
 145                150                155                160
Tyr Asp Ala Leu Ala Gly Gln Phe Ile Glu Ala Ser Ser Arg Glu Ala 
                 165                170                175
Arg Gln Ala Ile Leu Lys Gln Gly Gln Asp Gly Leu Ser Gly Val Lys 
             180                185                190
Glu Thr Asp Lys Lys Trp Ala Ser Gln Tyr Leu Lys Ile Met Gly Lys 
         195                200                205
Ile Leu Asp Gln Gly Glu Asp Phe Pro Ala Ser Glu Leu Ala Arg Ile 
     210                215                220
Ser Lys Leu Ile Glu Asn Lys Met Ser Glu Gly Lys Lys Glu Glu Leu 
 225                230                235                240
Gln Arg Ser Leu Asn Ile Leu Thr Ala Phe Arg Lys Lys Gly Ala Glu 
                 245                250                255
Lys Glu Glu Leu 
             260



<210> 8485
<211> 892
<212> DNA
<213> Homo sapiens
<308> X94910
<400> 8485

cggccggcg  tatggctgc  gctgtgccc  gcgccgcat  tctctcccc  ctgcttccc  60
ttctcctgg  cttcctgct  ctctccgct  cgcatggcg  cagcggcct  cacaccaag  120
gcgcccttc  cctggatac  gtcactttc  acaaggtca  tcccaaaag  aagttcgtc  180
tggtgaagt  cgacaccca  tacccctac  gtgagaagc  ggatgagtt  aagcgtctt  240
ctgaaaact  ggcttccag  gatgatctc  tggtggcag  ggtggggat  tcagattat  300
gtgacaagc  gaacatgga  ctgagtgag  aatacaagc  ggacaaaga  agctaccca  360
tcttctacc  cttccggga  ggggacttt  agaacccag  cccatacac  ggggcagtt  420
aggttggag  catccagcg  tggctgaag  ggcaagggg  ctacctagg  atgcctggt  480
gcctgcctg  atacgacgc  ctggccggg  agttcatca  ggcctctgg  gtggaggcc  540
gccaggccc  cttgaagca  gggcaagat  acctctcaa  tgtgaagga  actcagaag  600
agtgggccg  gcaatacct  aagatcatg  ggaagatct  agaccaagg  gaggacttc  660
cagcatcag  gatgacacg  atcgccagg  tgattgaga  gaacaagat  agtgacggc  720
agaaggagg  gctccagaa  agcttaaac  tcctgactg  cttccagaa  aagggggcc  780
agaaagagg  gctgtaaaa  ggctgtctg  gattttcca  ggtttggtg  gggtaggga  840
gggagagtt  acctgctgg  tgtgagtcc  ttgtggaat  taagggggc  cg  892



<210> 8486
<211> 261
<212> PRT
<213> Homo sapiens
<308> P30040
<400> 8486

Met Ala Ala Ala Val Pro Arg Ala Ala Phe Leu Ser Pro Leu Leu Pro 
  1               5                  10                  15
Leu Leu Leu Gly Phe Leu Leu Leu Ser Ala Pro His Gly Gly Ser Gly 
             20                  25                  30
Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys 
         35                  40                  45
Val Ile Pro Lys Ser Lys Phe Val Leu Val Lys Phe Asp Thr Gln Tyr 
     50                  55                  60
Pro Tyr Gly Glu Lys Gln Asp Glu Phe Lys Arg Leu Ala Glu Asn Ser 
 65                  70                  75                  80
Ala Ser Ser Asp Asp Leu Leu Val Ala Glu Val Gly Ile Ser Asp Tyr 
                 85                  90                  95
Gly Asp Lys Leu Asn Met Glu Leu Ser Glu Lys Tyr Lys Leu Asp Lys 
             100                105                110
Glu Ser Tyr Pro Val Phe Tyr Leu Phe Arg Asp Gly Asp Phe Glu Asn 
         115                120                125
Pro Val Pro Tyr Thr Gly Ala Val Lys Val Gly Ala Ile Gln Arg Trp 
     130                135                140
Leu Lys Gly Gln Gly Val Tyr Leu Gly Met Pro Gly Cys Leu Pro Val 
 145                150                155                160
Tyr Asp Ala Leu Ala Gly Glu Phe Ile Arg Ala Ser Gly Val Glu Ala 
                 165                170                175
Arg Gln Ala Leu Leu Lys Gln Gly Gln Asp Asn Leu Ser Ser Val Lys 
             180                185                190
Glu Thr Gln Lys Lys Trp Ala Glu Gln Tyr Leu Lys Ile Met Gly Lys 
         195                200                205
Ile Leu Asp Gln Gly Glu Asp Phe Pro Ala Ser Glu Met Thr Arg Ile 
     210                215                220
Ala Arg Leu Ile Glu Lys Asn Lys Met Ser Asp Gly Lys Lys Glu Glu 
 225                230                235                240
Leu Gln Lys Ser Leu Asn Ile Leu Thr Ala Phe Gln Lys Lys Gly Ala 
                 245                250                255
Glu Lys Glu Glu Leu 
             260



<210> 8487
<211> 3485
<212> DNA
<213> Rattus norvegicus
<308> U36580
<400> 8487

gaagtgaag  tgctgtcag  ggcgcctcc  gctcccggg  aagctgaga  tttccgcag  60
tggcggctg  ggcggcggc  gcagcggta  caactgcaa  agtagcaac  aaggctgtg  120
gtctgcagc  gtgttccca  tcgacattg  tcacggtga  ggtgacatc  ccctccagt  180
tcacaaaat  agtgtggta  ggttacgaa  accaggacc  aaacttcac  gagagccca  240
cctgctgtt  tgatgccga  agggagaca  aaagtccca  gcttggatg  ccgcctggg  300
ctgcctatc  gcctctgtc  ggaattagc  atcttcttt  tggttcccc  ggtcatggg  360
ctaacagag  caggtggtc  tgacacctt  ggtgcaggg  ggctaagct  ggctgtaca  420
ctggacagc  tagaaggtg  gaggaagga  gagagtctg  tacaacagg  aaatgctgt  480
gcccaggca  cggggctgg  gaatgctgg  cgcattgga  agctccagg  gcactacct  540
tttgtccag  cagctgggc  cgggcaagc  atggaggcg  aggccatgc  gcaacaggc  600
gaggctgtg  tagccaagc  tgaagctgt  cgctggcac  cagagcaga  gctgctgaa  660
agggccaag  gcagcatcc  cttcaatga  cccaagtat  ctcaacagt  gcacctgaa  720
aatcggcgg  gcccaggaa  agacatcaa  gtgacaggt  tgtgggaga  aaatgtaac  780
gggcgaggg  tgacggtgg  agtggtgga  gacggagtg  agcacaccg  ccaggacat  840
gcacccaac  atagcccag  gggaagcta  gacctcaac  ctaatgacc  agatcctat  900
ccccaccct  atgaggaga  cggtaacca  catgggacc  ggtgtgcag  agaaattgc  960
gctgtgccc  acaacagct  ctgtgcagt  ggtgtggcc  atgggagcc  aatagcagg  1020
atccgggtg  tggatggac  actcacaga  agtatggaa  ctgtggcat  caacaaaca  1080
tatcagatc  atgacatct  cagctgcag  tggggcccc  atgatgatg  gaagacagt  1140
gatggtcct  atcagcttg  gaaggctgc  ttacaacat  gagtgatgg  tggtcgcca  1200
ggctttgga  gtatctttg  ggttgccag  ggtaatggt  gccagcaca  tgacaactg  1260
aactatgat  gctatgcca  ctccatcta  actgtcacc  taggagctg  ggatgagga  1320
ggacggatg  ctttttatg  agaggagtg  gcctccatg  tggcagtca  cttcagtgg  1380
ggagacaag  tgctgcgga  cattgtgac  actgactgg  accttcaga  gggcactgg  1440
tgcactgaa  gccacacag  aacctcagc  gcagcccct  tagcagctg  catgatagc  1500
ctcatgctg  aggtgcggc  ctgcctcac  tggcgggat  tccagcaca  cattgtctt  1560
acagccact  agtatgaag  tcatcgtgc  gactggctc  ctaatgagg  tggattcag  1620
cacagccat  agcatggtt  cggcctgct  aacgcctgg  gacttgtca  tgcagccaa  1680
atctggacg  ctgtccctt  cttagcttc  tatgtcagc  ccatgctga  agaaaataa  1740
gctgttcca  ggtcccccc  ctctctgga  gtcctatgg  atgtcagca  gacggacct  1800
gagatgtcg  ggctgaaga  cctggaaca  gtggcggtg  cagtctcca  cactcaccc  1860
cgacgtggc  gcttagaac  gaaactgtt  tgtcccagt  gcatgatgt  tttgatcgg  1920
gcgccccgc  gcatggact  ggaccctaa  ggcttcaat  actggacat  ttccactgt  1980
cggtgctgg  gggaaagag  aagaggagt  tacagactg  ttatcaggg  tgtaggaga  2040
gagccgctc  aggtgggca  cctccagca  tggcagctg  cgctgtatg  ctccacgtg  2100
agtccagta  acatcaagg  cagacaaag  ctcttagaa  gtgctatga  tggaaaata  2160
ctgcatgat  acttcactc  gccttgccc  cctggactg  aaattcctg  ggaggatgg  2220
tacagcatt  cccctaaca  actcaagac  cttgtgctg  ttggctgct  cagtgtctt  2280
tggaccatt  actacatgc  agaagtgtg  ctgagccag  ggagcaagg  ttccaccca  2340
ggctgcagg  gaggatgct  cccctggcc  ccacaaagc  aaaactcca  ggaagtggg  2400
acagcacta  aatcaatgc  actgtgcag  agcaaggac  tggatggag  ggattcaga  2460
cacggggac  gcacaactg  ctctagctt  ctggcccca  agctgctgg  ggaagctga  2520
tggagtctg  cccagaaca  taagagtga  ctggattgt  ctccccacc  acccccaga  2580
ctgaaggat  gacagatct  ctgacccca  agcccagct  cttccatgt  caacaggct  2640
ttcctaaac  tggttatga  gctttcaat  atggatgct  aggagagaa  ggtcctgat  2700
gtgacatct  ccacccaag  cctctgaag  attctcagc  ttctcaaga  ggtgagggc  2760
atcttaatt  agcgcagtg  taagggact  gtgttcatg  ctcctctag  tgagctttg  2820
tgagagcct  tcgacaagg  gttggcgcc  aggccaggc  gcccttgat  tcatctctc  2880
cgggctagt  actgtcctc  gccatcagg  cctccaccc  ttcacaagt  atgcagcag  2940
tgcctgtat  cctaggaac  ctctcaaca  aagtgccgc  gtaccgagg  cccagagag  3000
ggctggcaa  agcctagac  tgcctaccc  gaaagcagc  gccttcatt  ccctttcct  3060
tgtgcctgt  ctgaagccc  taccttcac  accactcac  cttcctgct  aaggaatgg  3120
ggcgtgtcc  aggaaaact  ggaggcaca  gattcccag  cagcaccct  gctgcctca  3180
tggggaagt  gtcctgctg  gctgcagag  gctgagaca  agtgttgtc  aagatagca  3240
gggagcccc  gcctatgac  acctgtctt  ctctgcaaa  tgctcaggg  aatggcctt  3300
attccagag  ccagctgtc  gcctgactt  tcctccatt  ttggccttc  ccccttccc  3360
tctttggag  taattgtta  tatgaattt  ttaatgctt  agatttgat  tttactttt  3420
aaagcaaca  tttgttgaa  ttttttctg  acagctttc  aaaataaaa  gcagaagta  3480
aaaaa  3485



<210> 8488
<211> 783
<212> PRT
<213> Rattus norvegicus
<308> Q62849
<400> 8488

Met Pro Lys Gly Arg Gln Lys Val Pro Arg Leu Asp Ala Arg Leu Gly 
  1               5                  10                  15
Leu Pro Ile Cys Leu Cys Leu Glu Leu Ala Ile Phe Phe Leu Val Pro 
             20                  25                  30
Gln Val Met Gly Leu Thr Glu Ala Gly Gly Leu Asp Thr Leu Gly Ala 
         35                  40                  45
Gly Gly Leu Ser Trp Ala Val His Leu Asp Ser Leu Glu Gly Glu Arg 
     50                  55                  60
Lys Glu Glu Ser Leu Ile Gln Gln Ala Asn Ala Val Ala Gln Ala Ala 
 65                  70                  75                  80
Gly Leu Val Asn Ala Gly Arg Ile Gly Glu Leu Gln Gly His Tyr Leu 
                 85                  90                  95
Phe Val Gln Pro Ala Gly His Gly Gln Ala Met Glu Ala Glu Ala Met 
             100                105                110
Arg Gln Gln Ala Glu Ala Val Leu Ala Lys His Glu Ala Val Arg Trp 
         115                120                125
His Ser Glu Gln Arg Leu Leu Lys Arg Ala Lys Arg Ser Ile His Phe 
     130                135                140
Asn Asp Pro Lys Tyr Pro Gln Gln Trp His Leu Asn Asn Arg Arg Ser 
 145                150                155                160
Pro Gly Arg Asp Ile Asn Val Thr Gly Val Trp Glu Arg Asn Val Thr 
                 165                170                175
Gly Arg Gly Val Thr Val Val Val Val Asp Asp Gly Val Glu His Thr 
             180                185                190
Val Gln Asp Ile Ala Pro Asn Tyr Ser Pro Glu Gly Ser Tyr Asp Leu 
         195                200                205
Asn Ser Asn Asp Pro Asp Pro Met Pro His Pro Asp Glu Glu Asn Gly 
     210                215                220
Asn His His Gly Thr Arg Cys Ala Gly Glu Ile Ala Ala Val Pro Asn 
 225                230                235                240
Asn Ser Phe Cys Ala Val Gly Val Ala Tyr Gly Ser Arg Ile Ala Gly 
                 245                250                255
Ile Arg Val Leu Asp Gly Pro Leu Thr Asp Ser Met Glu Ala Val Ala 
             260                265                270
Phe Asn Lys His Tyr Gln Ile Asn Asp Ile Tyr Ser Cys Ser Trp Gly 
         275                280                285
Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro His Gln Leu Gly Lys 
     290                295                300
Ala Ala Leu Gln His Gly Val Met Ala Gly Arg Gln Gly Phe Gly Ser 
 305                310                315                320
Ile Phe Val Val Ala Ser Gly Asn Gly Gly Gln His Asn Asp Asn Cys 
                 325                330                335
Asn Tyr Asp Gly Tyr Ala Asn Ser Ile Tyr Thr Val Thr Ile Gly Ala 
             340                345                350
Val Asp Glu Glu Gly Arg Met Pro Phe Tyr Ala Glu Glu Cys Ala Ser 
         355                360                365
Met Leu Ala Val Thr Phe Ser Gly Gly Asp Lys Met Leu Arg Ser Ile 
     370                375                380
Val Thr Thr Asp Trp Asp Leu Gln Lys Gly Thr Gly Cys Thr Glu Gly 
 385                390                395                400
His Thr Gly Thr Ser Ala Ala Ala Pro Leu Ala Ala Gly Met Ile Ala 
                 405                410                415
Leu Met Leu Gln Val Arg Pro Cys Leu Thr Trp Arg Asp Val Gln His 
             420                425                430
Ile Ile Val Phe Thr Ala Thr Gln Tyr Glu Asp His Arg Ala Asp Trp 
         435                440                445
Leu Thr Asn Glu Ala Gly Phe Ser His Ser His Gln His Gly Phe Gly 
     450                455                460
Leu Leu Asn Ala Trp Arg Leu Val Asn Ala Ala Lys Ile Trp Thr Ser 
 465                470                475                480
Val Pro Tyr Leu Ala Ser Tyr Val Ser Pro Met Leu Lys Glu Asn Lys 
                 485                490                495
Ala Val Pro Arg Ser Pro His Ser Leu Glu Val Leu Trp Asn Val Ser 
             500                505                510
Arg Thr Asp Leu Glu Met Ser Gly Leu Lys Thr Leu Glu His Val Ala 
         515                520                525
Val Thr Val Ser Ile Thr His Pro Arg Arg Gly Ser Leu Glu Leu Lys 
     530                535                540
Leu Phe Cys Pro Ser Gly Met Met Ser Leu Ile Gly Ala Pro Arg Ser 
 545                550                555                560
Met Asp Ser Asp Pro Asn Gly Phe Asn Asp Trp Thr Phe Ser Thr Val 
                 565                570                575
Arg Cys Trp Gly Glu Arg Ala Arg Gly Val Tyr Arg Leu Val Ile Arg 
             580                585                590
Asp Val Gly Asp Glu Pro Leu Gln Val Gly Ile Leu Gln Gln Trp Gln 
         595                600                605
Leu Thr Leu Tyr Gly Ser Thr Trp Ser Pro Val Asp Ile Lys Asp Arg 
     610                615                620
Gln Ser Leu Leu Glu Ser Ala Met Ser Gly Lys Tyr Leu His Asp Asp 
 625                630                635                640
Phe Thr Leu Pro Cys Pro Pro Gly Leu Lys Ile Pro Glu Glu Asp Gly 
                 645                650                655
Tyr Ser Ile Thr Pro Asn Thr Leu Lys Thr Leu Val Leu Val Gly Cys 
             660                665                670
Phe Ser Val Phe Trp Thr Ile Tyr Tyr Met Leu Glu Val Cys Leu Ser 
         675                680                685
Gln Arg Ser Lys Ala Ser Thr His Gly Cys Arg Arg Gly Cys Cys Pro 
     690                695                700
Trp Pro Pro Gln Ser Gln Asn Ser Lys Glu Val Gly Thr Ala Leu Glu 
 705                710                715                720
Ser Met Pro Leu Cys Ser Ser Lys Asp Leu Asp Gly Val Asp Ser Glu 
                 725                730                735
His Gly Asp Cys Thr Thr Ala Ser Ser Leu Leu Ala Pro Glu Leu Leu 
             740                745                750
Gly Glu Ala Asp Trp Ser Leu Ser Gln Asn Ser Lys Ser Asp Leu Asp 
         755                760                765
Cys Pro Pro His Gln Pro Pro Asp Leu Lys Asp Gly Gln Ile Cys 
     770                775                780



<210> 8489
<211> 3497
<212> DNA
<213> Homo sapiens
<308> BC010696
<400> 8489

cactgctcc  ccggctccc  ggaagccgc  agtttccgc  gggaggcgg  ggcagctgc  60
gcggggccg  tctgtagcc  ttgctgagt  aacactact  acagtgaaa  tgatgcctt  120
tctccattt  cacaacatg  gtgtgacgt  gttagccag  ccaggagct  aacctcatg  180
agaatccag  ccactgctc  gatgccgaa  gggaggcag  aagtgccac  cttggatgc  240
cccctgggc  tgcccacct  cctctggct  gaattagcc  ggctcttct  actggttcc  300
tgggtcatg  gcctggcag  gacaggtgg  cctgatggc  agggcacag  ggggccgag  360
tgggctgtg  acctggaaa  cctggaagg  gacggggag  aagagactc  ggagcagca  420
gcggatgcc  tggcccagg  agcagggct  gtgaatgct  gacgcatcg  agagcttca  480
gggcactac  tctttgtcc  gcctgctgg  cacaggccg  ccctggagg  ggaggccat  540
cggcagcag  tggaggctg  gttggctgg  catgaagct  tgcgctggc  ctcagagca  600
aggctgcta  ggcgggcca  gcgcagcgt  cacttcaac  accccaagt  cccgcagca  660
tggcacctg  ataaccgac  gagcccggg  agggacatc  acgtgacgg  tgtgtggga  720
cgcaatgtg  ctgggcgag  ggtgacggt  gtggtagtg  atgacggag  ggaacacac  780
atccaggac  ttgcaccca  ctatagccc  gagggtagc  atgacctca  ctctaatga  840
cctgacccc  tgccccacc  ggatgtgga  aatggcaac  accatggca  gcgatgtgc  900
ggagagatc  cggctgtgc  caacaacag  ttctgtgcc  tgggcgtgg  ctacgggag  960
cgcatcgca  gtatccggg  actggatgg  cctctcaca  acagcatgg  ggcagtggc  1020
ttcaacaag  actatcaga  caatgacat  tacagctgc  gctggggac  agatgacga  1080
gggaagaca  tggatggcc  ccatcagct  ggaaaggct  ccttacaac  tggggtgat  1140
gctggtcgc  agggctttg  gagcatctt  gtggtagcc  gtggcaacg  aggccaaca  1200
aacgacaac  gcaactacg  tggctacgc  aactccatc  acaccgtca  cataggagc  1260
gtggatgag  agggacgca  gcctttcta  gcagaagaa  gtgcctcca  gctggcagt  1320
accttcagt  gtggggaca  gatgcttcg  agcattgtg  ccactgact  ggaccttca  1380
aagggcact  gctgcactg  gggccacac  gggacctca  ctgcagcgc  tctggcagc  1440
ggcatgata  ccttaatgc  gcaggtgcg  ccctgcctc  cgtggcgtg  cgtccagca  1500
atcattgtc  tcacagcca  ccggtatga  gatcgccgt  cagagtggg  caccaacga  1560
gcaggcttc  gccatagcc  ccagcacgg  ttcggcctc  tcaacgcct  gaggctcgt  1620
aatgcagcc  agatctgga  atctgtccc  tacttagca  cctacgtca  tcccgtgtt  1680
aaagaaaac  aggcgattc  gcagtcccc  cgttccctg  aggtcctgt  gaatgtcag  1740
aggatggac  tggagatgt  agggctgaa  accctggag  atgtggcag  gacagtctc  1800
atcactcac  cacggcgcg  cagcttgga  ctgaagctg  tctgcccca  tggcatgat  1860
tccctcatc  gcgcccccc  cagcatgga  tcggatccc  acggcttca  tgactggac  1920
ttctccact  tgcgatgct  gggggagag  gcccgaggg  cctacaggc  tgtcatcag  1980
gatgtcggg  atgagtcat  ccaggtcgg  atcctccgg  aatggcagc  gaccctata  2040
ggctctgtg  ggagtgcag  agacatcag  gacagacaa  ggctgttag  gagtgccat  2100
agtggaaaa  acctgcacg  tgacttcgc  ctgccctgc  caccggggc  gaaaattcc  2160
gaggaagat  gttacacca  cacccccaa  accctcaag  ccctggtgc  ggtaggctg  2220
ttcaccgtc  tctggactg  ttactacat  ctggaagta  atttgagcc  gaggaatgt  2280
gcttccaat  aagtttgta  gagtggacc  tgccactgg  cccatcgga  ccggaaagc  2340
aaggaggaa  ggacagagc  agaatcagt  ccactttgc  gcagcaagg  tccagacga  2400
gtggaaaca  agagcaggg  ccctcccac  acctctgac  tccttgccc  agacctgct  2460
gagcaaggg  actggagcc  gtcccagaa  aagagcgcc  tggactgcc  tcatcagca  2520
ctagacgta  cgcacggga  ggaggagca  atctgctga  ctcagggcc  gacagtgtg  2580
gacaggctc  tctttccca  aattaggga  ctcttgaca  aaagcagtt  tgatgctta  2640
atctggaat  tgaggcatc  tctgactcc  ctcaaagag  gtgagggcc  tcttaagat  2700
caaatggtg  aggattgct  ccagagaag  ctggtcaga  ccacagggt  tgcctccag  2760
caaacggga  cttttggtg  gaaggtgtt  gacagggga  tggcgcccc  ctttggttt  2820
gcctccatc  tcatctctc  tgggccaag  cagctgcct  ggtccccca  gcatggggg  2880
ccccttccc  catataagt  gagaaggtg  ctgccatag  caggagcgc  tctcaatgg  2940
aacatcact  gggtcactt  ggaagagga  ttcggggta  aggctggga  gagcccctg  3000
acatgcctg  cctgaaagc  gctgcctcc  ttatccatt  ccaagatgc  tgatcagaa  3060
ccaaccatg  atgaacccc  ggctccttc  ccaccccca  gattggtat  atgctgccg  3120
cacagctgg  atacacacg  ctcccccag  cctgagctg  ttcactagg  aatcctgcg  3180
caggactgc  gagcagatg  cagatgcac  tgttggagg  gagagcctt  ggagccact  3240
ccactccag  cctgccacc  ccctgtctt  ctctgcaag  gctcaggga  atggccttc  3300
cgccggagg  cagctatct  cctgacagg  tgtgactct  ctctcaacc  tggccttct  3360
ccctcttct  agctagttg  ttgaatttt  tttaatgct  aagatttgt  tttctcttt  3420
cacagcaac  ttttcttga  tttttttct  cacagcttt  ccaaaataa  aaccttcca  3480
acaaaaaaa  aaaaaaa  3497



<210> 8490
<211> 785
<212> PRT
<213> Homo sapiens
<308> Q16549
<400> 8490

Met Pro Lys Gly Arg Gln Lys Val Pro His Leu Asp Ala Pro Leu Gly 
  1               5                  10                  15
Leu Pro Thr Cys Leu Trp Leu Glu Leu Ala Gly Leu Phe Leu Leu Val 
             20                  25                  30
Pro Trp Val Met Gly Leu Ala Gly Thr Gly Gly Pro Asp Gly Gln Gly 
         35                  40                  45
Thr Gly Gly Ala Ser Trp Ala Val His Leu Glu Ser Leu Glu Gly Asp 
     50                  55                  60
Gly Glu Glu Glu Thr Leu Glu Gln Gln Ala Asp Ala Leu Ala Gln Ala 
 65                  70                  75                  80
Ala Gly Leu Val Asn Ala Gly Arg Ile Gly Glu Leu Gln Gly His Tyr 
                 85                  90                  95
Leu Phe Val Gln Pro Ala Gly His Arg Pro Ala Leu Glu Val Glu Pro 
             100                105                110
Ile Arg Gln Gln Val Glu Ala Val Leu Ala Gly His Glu Ala Val Arg 
         115                120                125
Trp His Ser Glu Gln Arg Leu Leu Arg Arg Ala Lys Arg Ser Val His 
     130                135                140
Phe Asn Asp Pro Lys Tyr Pro Gln Gln Trp His Leu Asn Asn Arg Arg 
 145                150                155                160
Ser Pro Gly Arg Asp Ile Asn Val Thr Gly Val Trp Glu Arg Asn Val 
                 165                170                175
Thr Gly Arg Gly Val Thr Val Val Val Val Asp Asp Gly Val Glu His 
             180                185                190
Thr Ile Gln Asp Ile Ala Pro Asn Tyr Ser Pro Glu Gly Ser Tyr Asp 
         195                200                205
Leu Asn Ser Asn Asp Pro Asp Pro Met Pro His Pro Asp Val Glu Asn 
     210                215                220
Gly Asn His His Gly Thr Arg Cys Ala Gly Glu Ile Ala Ala Val Pro 
 225                230                235                240
Asn Asn Ser Phe Cys Ala Val Gly Val Ala Tyr Gly Ser Arg Ile Ala 
                 245                250                255
Gly Ile Arg Val Leu Asp Gly Pro Leu Thr Asp Ser Met Glu Ala Val 
             260                265                270
Ala Phe Asn Lys His Tyr Gln Ile Asn Asp Ile Tyr Ser Cys Ser Trp 
         275                280                285
Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro His Gln Leu Gly 
     290                295                300
Lys Ala Ala Leu Gln His Gly Val Ile Ala Gly Arg Gln Gly Phe Gly 
 305                310                315                320
Ser Ile Phe Val Val Ala Ser Gly Asn Gly Gly Gln His Asn Asp Asn 
                 325                330                335
Cys Asn Tyr Asp Gly Tyr Ala Asn Ser Ile Tyr Thr Val Thr Ile Gly 
             340                345                350
Ala Val Asp Glu Glu Gly Arg Met Pro Phe Tyr Ala Glu Glu Cys Ala 
         355                360                365
Ser Met Leu Ala Val Thr Phe Ser Gly Gly Asp Lys Met Leu Arg Ser 
     370                375                380
Ile Val Thr Thr Asp Trp Asp Leu Gln Lys Gly Thr Gly Cys Thr Glu 
 385                390                395                400
Gly His Thr Gly Thr Ser Ala Ala Ala Pro Leu Ala Ala Gly Met Ile 
                 405                410                415
Ala Leu Met Leu Gln Val Arg Pro Cys Leu Thr Trp Arg Asp Val Gln 
             420                425                430
His Ile Ile Val Phe Thr Ala Thr Arg Tyr Glu Asp Arg Arg Ala Glu 
         435                440                445
Trp Val Thr Asn Glu Ala Gly Phe Ser His Ser His Gln His Gly Phe 
     450                455                460
Gly Leu Leu Asn Ala Trp Arg Leu Val Asn Ala Ala Lys Ile Trp Thr 
 465                470                475                480
Ser Val Pro Tyr Leu Ala Ser Tyr Val Ser Pro Val Leu Lys Glu Asn 
                 485                490                495
Lys Ala Ile Pro Gln Ser Pro Arg Ser Leu Glu Val Leu Trp Asn Val 
             500                505                510
Ser Arg Met Asp Leu Glu Met Ser Gly Leu Lys Thr Leu Glu His Val 
         515                520                525
Ala Val Thr Val Ser Ile Thr His Pro Arg Arg Gly Ser Leu Glu Leu 
     530                535                540
Lys Leu Phe Cys Pro Ser Gly Met Met Ser Leu Ile Gly Ala Pro Arg 
 545                550                555                560
Ser Met Asp Ser Asp Pro Asn Gly Phe Asn Asp Trp Thr Phe Ser Thr 
                 565                570                575
Val Arg Cys Trp Gly Glu Arg Ala Arg Gly Thr Tyr Arg Leu Val Ile 
             580                585                590
Arg Asp Val Gly Asp Glu Ser Phe Gln Val Gly Ile Leu Arg Gln Trp 
         595                600                605
Gln Leu Thr Leu Tyr Gly Ser Val Trp Ser Ala Val Asp Ile Arg Asp 
     610                615                620
Arg Gln Arg Leu Leu Glu Ser Ala Met Ser Gly Lys Tyr Leu His Asp 
 625                630                635                640
Asp Phe Ala Leu Pro Cys Pro Pro Gly Leu Lys Ile Pro Glu Glu Asp 
                 645                650                655
Gly Tyr Thr Ile Thr Pro Asn Thr Leu Lys Thr Leu Val Leu Val Gly 
             660                665                670
Cys Phe Thr Val Phe Trp Thr Val Tyr Tyr Met Leu Glu Val Tyr Leu 
         675                680                685
Ser Gln Arg Asn Val Ala Ser Asn Gln Val Cys Arg Ser Gly Pro Cys 
     690                695                700
His Trp Pro His Arg Ser Arg Lys Ala Lys Glu Glu Gly Thr Glu Leu 
 705                710                715                720
Glu Ser Val Pro Leu Cys Ser Ser Lys Asp Pro Asp Glu Val Glu Thr 
                 725                730                735
Glu Ser Arg Gly Pro Pro Thr Thr Ser Asp Leu Leu Ala Pro Asp Leu 
             740                745                750
Leu Glu Gln Gly Asp Trp Ser Leu Ser Gln Asn Lys Ser Ala Leu Asp 
         755                760                765
Cys Pro His Gln His Leu Asp Val Pro His Gly Lys Glu Glu Gln Ile 
     770                775                780
Cys 
 785



<210> 8491
<211> 2519
<212> DNA
<213> Rattus norvegicus
<308> U36771
<400> 8491

cagccttgg  cgatgtaaa  acacgaatg  ggactgggt  gactttggc  tcaaaccta  60
cttcttcag  tccgcaacg  tgaaatgga  ggagagcct  atgagccgg  agaggccct  120
cgtgggaag  tgttgctat  catgcacgc  tcagagctg  gaaaggttc  tcaacccca  180
tatcccacc  ctgggtttg  ggaatgtta  ttatatcaa  gaaactcac  caaggcacc  240
aggatggct  gcaagacgg  tttcttaca  cctttttgt  caagagcgc  atgtccaca  300
gggcatgtt  gccaccagt  tcactgaca  tgtactgaa  agcagcaga  tccaagagg  360
aattgctga  gtggctgca  aattgaacc  ggatggatc  gcccagcag  agtccaaag  420
catccagaa  gtgaaaagg  aagccagga  gatcctcca  gaaatggtt  ctacagtct  480
ccccgggat  atcaggctg  ctggctggg  gttactaaa  ctcttcaac  gcttcttct  540
gaacattca  attcacaag  gtcaacttg  gatggtgaa  gctgcaact  agacgaatc  600
gccgctctt  tttctgccg  tgcacagat  ccacatcga  tacctgttg  tcaccttca  660
cctcttctg  cacaacatc  aagctccat  catcgcctc  ggcaacaac  tcaacatcc  720
catcttcag  accttgatt  acaagcttg  gggcttttt  ataagacgg  ggcttgacg  780
aactccaga  ggacgcaaa  acattctgt  cagagcgtt  ctccatggg  atgtagttg  840
actcctccg  cagcagcag  tcctggaga  cttcctgga  ggcacccgc  cccgcagtg  900
caagacctc  tgtgcccgg  ccggcgtcc  gtcagtggt  gtggatact  tgtcatcca  960
caccatccc  gacatcctg  tcatccctg  gggcatctc  tatgatcgg  taatcgaag  1020
tcactacaa  ggtgaacag  tgggcaagc  caagaagaa  gaaagtctc  ggagtgtgg  1080
aagaggcgt  atcagaatg  tgcggaaaa  ctacggcta  gtccgagtg  actttgcac  1140
gccattttc  ttgaaggaa  atttagaag  ccaaagtca  aaacctgta  ctgctcccc  1200
ctctttgga  caagcactg  taccagcaa  ccttccttc  agacctgat  ctgctgctg  1260
cgaacatga  gacatgtcc  gtaatgagt  gagaaacgc  gcagacgaa  ccttccgaa  1320
gaggctgat  gcaaacctg  cggagcaca  tctcctcac  gccagcaag  cctgcgcta  1380
catgtccac  cacattgtg  cctgcctgc  cctctacag  cactggcag  gaatccacc  1440
ctccacgct  gtggaagac  tctttgtga  gaaggagga  gtcctagct  gggattttg  1500
cctgggctt  tccgggaat  cagaagacg  agtcatgca  gctattcag  ttctgggca  1560
ctgtgtcac  atcacccac  ctagcagga  ggatgaatt  tttattact  ccagcacaa  1620
tgtcccgtc  gtctttgaa  tcaacttct  cagcaatgg  gtacttcat  tctttatca  1680
ggaagccat  atagcttgc  gcatttatg  agtccagaa  aagaggggt  ccggaggtc  1740
gccggagcc  ggcaacctg  tcagccagg  gcagctggt  cggaaggcc  ccagcctgt  1800
ctaccttct  tctaatgaa  gtaccattt  tctgccctg  cagacattt  accaggttt  1860
tcacgagac  gtaggaaag  tcatccagt  cggaattct  acagtggca  agcaagatg  1920
ccaggaaga  gtcagtcct  gccttgcag  gcagcagtg  aacaagaag  ttccggagc  1980
tctgaactg  agaagtgac  aagaagatg  ggacagtga  tttggtgag  agcagcgtg  2040
ttgctacct  aaggtgagc  aggccaagg  gcaccagca  ttcatcacc  ttctgcaga  2100
gcttctggg  cccctgcta  aagcctaca  ctctgctgc  atctttgtc  acaccttcc  2160
cgcgccagt  cccgagtct  agtacctgc  gaagctgca  aggtacctt  tcaccagga  2220
ggagaggaa  gtcgcggtg  acgctgaga  tgccacata  tgtcttgtg  agaatgctg  2280
gaaaatgtt  aaggacatc  gggttttca  agagaccaa  cagaagcga  cgtctgtct  2340
agaactgag  accactttc  tacctcagg  cagccggca  aagctcctg  aatacattc  2400
gagcttcgt  gtgctgtag  gttccctca  cacctatct  cgtgaggag  tgatgagtc  2460
tttgcagac  ccagtctga  ccagagtgg  aagtttcct  gacatgggc  agcctgccg  2519



<210> 8492
<211> 828
<212> PRT
<213> Rattus norvegicus
<308> P97564
<400> 8492

Met Glu Glu Ser Ser Val Thr Ile Gly Thr Ile Asp Val Ser Tyr Leu 
  1               5                  10                  15
Pro Asn Ser Ser Glu Tyr Ser Leu Gly Arg Cys Lys His Thr Asn Glu 
             20                  25                  30
Asp Trp Val Asp Cys Gly Phe Lys Pro Thr Phe Phe Arg Ser Ala Thr 
         35                  40                  45
Leu Lys Trp Lys Glu Ser Leu Met Ser Arg Lys Arg Pro Phe Val Gly 
     50                  55                  60
Arg Cys Cys Tyr Ser Cys Thr Pro Gln Ser Trp Glu Arg Phe Phe Asn 
 65                  70                  75                  80
Pro Ser Ile Pro Ser Leu Gly Leu Arg Asn Val Ile Tyr Ile Asn Glu 
                 85                  90                  95
Thr His Thr Arg His Arg Gly Trp Leu Ala Arg Arg Leu Ser Tyr Ile 
             100                105                110
Leu Phe Val Gln Glu Arg Asp Val His Lys Gly Met Phe Ala Thr Ser 
         115                120                125
Ile Thr Asp Asn Val Leu Asn Ser Ser Arg Val Gln Glu Ala Ile Ala 
     130                135                140
Glu Val Ala Ala Glu Leu Asn Pro Asp Gly Ser Ala Gln Gln Gln Ser 
 145                150                155                160
Lys Ala Ile Gln Lys Val Lys Arg Lys Ala Arg Lys Ile Leu Gln Glu 
                 165                170                175
Met Val Ala Thr Val Ser Pro Gly Met Ile Arg Leu Thr Gly Trp Val 
             180                185                190
Leu Leu Lys Leu Phe Asn Ser Phe Phe Trp Asn Ile Gln Ile His Lys 
         195                200                205
Gly Gln Leu Glu Met Val Lys Ala Ala Thr Glu Thr Asn Leu Pro Leu 
     210                215                220
Leu Phe Leu Pro Val His Arg Ser His Ile Asp Tyr Leu Leu Leu Thr 
 225                230                235                240
Phe Ile Leu Phe Cys His Asn Ile Lys Ala Pro Tyr Ile Ala Ser Gly 
                 245                250                255
Asn Asn Leu Asn Ile Pro Ile Phe Ser Thr Leu Ile His Lys Leu Gly 
             260                265                270
Gly Phe Phe Ile Arg Arg Arg Leu Asp Glu Thr Pro Asp Gly Arg Lys 
         275                280                285
Asp Ile Leu Tyr Arg Ala Leu Leu His Gly His Ile Val Glu Leu Leu 
     290                295                300
Arg Gln Gln Gln Phe Leu Glu Ile Phe Leu Glu Gly Thr Arg Ser Arg 
 305                310                315                320
Ser Gly Lys Thr Ser Cys Ala Arg Ala Gly Leu Leu Ser Val Val Val 
                 325                330                335
Asp Thr Leu Ser Ser Asn Thr Ile Pro Asp Ile Leu Val Ile Pro Val 
             340                345                350
Gly Ile Ser Tyr Asp Arg Ile Ile Glu Gly His Tyr Asn Gly Glu Gln 
         355                360                365
Leu Gly Lys Pro Lys Lys Asn Glu Ser Leu Trp Ser Val Ala Arg Gly 
     370                375                380
Val Ile Arg Met Leu Arg Lys Asn Tyr Gly Tyr Val Arg Val Asp Phe 
 385                390                395                400
Ala Gln Pro Phe Ser Leu Lys Glu Tyr Leu Glu Gly Gln Ser Gln Lys 
                 405                410                415
Pro Val Ser Ala Pro Leu Ser Leu Glu Gln Ala Leu Leu Pro Ala Ile 
             420                425                430
Leu Pro Ser Arg Pro Asp Ala Ala Ala Ala Glu His Glu Asp Met Ser 
         435                440                445
Ser Asn Glu Ser Arg Asn Ala Ala Asp Glu Ala Phe Arg Arg Arg Leu 
     450                455                460
Ile Ala Asn Leu Ala Glu His Ile Leu Phe Thr Ala Ser Lys Ser Cys 
 465                470                475                480
Ala Ile Met Ser Thr His Ile Val Ala Cys Leu Leu Leu Tyr Arg His 
                 485                490                495
Arg Gln Gly Ile His Leu Ser Thr Leu Val Glu Asp Phe Phe Val Met 
             500                505                510
Lys Glu Glu Val Leu Ala Arg Asp Phe Asp Leu Gly Phe Ser Gly Asn 
         515                520                525
Ser Glu Asp Val Val Met His Ala Ile Gln Leu Leu Gly Asn Cys Val 
     530                535                540
Thr Ile Thr His Thr Ser Arg Lys Asp Glu Phe Phe Ile Thr Pro Ser 
 545                550                555                560
Thr Thr Val Pro Ser Val Phe Glu Leu Asn Phe Tyr Ser Asn Gly Val 
                 565                570                575
Leu His Val Phe Ile Met Glu Ala Ile Ile Ala Cys Ser Ile Tyr Ala 
             580                585                590
Val Gln Asn Lys Arg Gly Ser Gly Gly Ser Ala Gly Gly Leu Gly Asn 
         595                600                605
Leu Ile Ser Gln Glu Gln Leu Val Arg Lys Ala Ala Ser Leu Cys Tyr 
     610                615                620
Leu Leu Ser Asn Glu Gly Thr Ile Ser Leu Pro Cys Gln Thr Phe Tyr 
 625                630                635                640
Gln Val Cys Gln Glu Thr Val Gly Lys Phe Ile Gln Tyr Gly Ile Leu 
                 645                650                655
Thr Val Ala Glu Gln Asp Asp Gln Glu Asp Val Ser Pro Gly Leu Ala 
             660                665                670
Glu Gln Gln Trp Asn Lys Lys Leu Pro Glu Pro Leu Asn Trp Arg Ser 
         675                680                685
Asp Glu Glu Asp Glu Asp Ser Asp Phe Gly Glu Glu Gln Arg Asp Cys 
     690                695                700
Tyr Leu Lys Val Ser Gln Ala Lys Glu His Gln Gln Phe Ile Thr Phe 
 705                710                715                720
Leu Gln Arg Leu Leu Gly Pro Leu Leu Glu Ala Tyr Ser Ser Ala Ala 
                 725                730                735
Ile Phe Val His Thr Phe Arg Gly Pro Val Pro Glu Ser Glu Tyr Leu 
             740                745                750
Gln Lys Leu His Arg Tyr Leu Leu Thr Arg Thr Glu Arg Asn Val Ala 
         755                760                765
Val Tyr Ala Glu Ser Ala Thr Tyr Cys Leu Val Lys Asn Ala Val Lys 
     770                775                780
Met Phe Lys Asp Ile Gly Val Phe Lys Glu Thr Lys Gln Lys Arg Ala 
 785                790                795                800
Ser Val Leu Glu Leu Ser Thr Thr Phe Leu Pro Gln Gly Ser Arg Gln 
                 805                810                815
Lys Leu Leu Glu Tyr Ile Leu Ser Phe Val Val Leu 
             820                825



<210> 8493
<211> 6346
<212> DNA
<213> Homo sapiens
<308> XM_034422
<400> 8493

ggactggaa  tgcgggctt  tgcagcagc  gaagctgga  ctgctaggg  agcagcggc  60
cccctgttg  atggacatt  tgcacccga  actgatagc  gagtcctga  gttttatgt  120
atgaaacag  agaactttc  tcccagcac  tgatttggg  attacactt  gtgacatgg  180
tgaatctgc  ctgaccctt  gtacaatag  tgtttctta  ctgccacat  catcagaat  240
cagtgttgg  cgatgtaag  acacaagtg  ggaatgggg  gagtgtggc  ttagaccca  300
catcttcag  tctgcaact  taaaatgga  agaaagcct  atgagtcgg  aaaggccat  360
tgttggaag  tgttgttac  cctgcactc  ccagagctg  gacaaattt  tcaacccca  420
tatcccgtc  ttgggtttg  ggaatgtta  ttatatcaa  gaaactcac  caagacacc  480
cggatggct  gcaagacgc  tttcttacg  tctttttat  caagagcga  atgtgcata  540
gggcatgtt  gccaccaat  tgactgaaa  tgtgctgaa  agcagtaga  tacaagagg  600
aattgcaga  gtggctgct  aattaaacc  tgatggttc  gcccagcag  aatcaaaag  660
cgttaacaa  gtgaaaaag  aagctaaaa  gattcttca  gaaatggtt  ccactgtct  720
accggcaat  atcagactg  ctgggtggg  gctgctaaa  ctgttcaac  gcttctttt  780
gaacattca  attcacaaa  gtcaacttg  gatggttaa  gctgcaact  agacgaatt  840
gccgcttct  tttctacca  ttcatagat  ccatattga  tatctgctg  tcactttca  900
tctcttctg  cataacatc  aagcaccat  cattgcttc  ggcaataat  tcaacatcc  960
aatcttcag  accttgatc  ataagcttg  gggcttctt  atacgacga  ggctcgatg  1020
aacaccaga  ggacggaaa  atgttctct  tagagcttt  ctccatggg  atatagttg  1080
attacttcg  cagcagcaa  tcttggaga  cttcctgga  ggcacacgt  ctaggagtg  1140
aaaaacctc  tgtgctcgg  caggacttt  gtcagttgt  gtagatact  tgtctacca  1200
tgtcatccc  gacatcttg  taatacctg  tggaatctc  tatgatcgc  ttatcgaag  1260
tcactacaa  ggtgaacaa  tgggcaaac  taagaagaa  gagagcctg  ggagtgtag  1320
aagaggtgt  attagaatg  tacgaaaaa  ctatggttg  gtccgagtg  attttgcac  1380
gccattttc  ttaaaggaa  atttagaaa  ccaaagtca  aaaccggtg  ctgctctac  1440
ttccctgga  caagcgttg  taccagcta  acttccttc  agacccagt  atgctgctg  1500
tgaaggtag  gacacgtcc  ttaatgagt  cagaaatgc  acagatgaa  ccctacgaa  1560
gaggttgat  gcaaatctg  ctgagcata  tctattcac  gctagcaag  cctgtgcca  1620
tatgtccac  cacattgtg  cttgcctgc  cctctacag  cacaggcag  gaattgatc  1680
ctccacatt  gtcgaagac  tctttgtga  gaaagagga  gtcctggct  gtgattttg  1740
cctggggtt  tcaggaaat  cagaagatg  agtaatgca  gccatacag  tgctgggaa  1800
ttgtgtcac  atcacccac  ctagcagga  cgatgagtt  tttatcacc  ccagcacaa  1860
tgtcccatc  gtcttcgaa  tcaacttct  cagcaatgg  gtacttcat  tctttatca  1920
ggaggccat  atagcttgc  gcctttatg  agttctgaa  aagagggga  tggggggtc  1980
cactagcac  ccacctaac  tgatcagcc  ggagcagct  gtgcggaag  cggccagcc  2040
gtgctacct  ctctccaat  aaggcacca  ctcactgcc  tgccagaca  tttaccaag  2100
ctgccatga  acagtagga  agtttatcc  gtatggcat  cttacagtg  cagagcacg  2160
tgaccagga  gatatcagt  ctagtcttg  tgagcagca  tgggacaag  agcttccag  2220
acctttgtc  tggagaagt  atgaagaag  tgaagacag  gactttggg  aggaacagc  2280
agattgcta  ctgaaggtg  gccaatcca  ggagcacca  cagtttatc  ccttcttac  2340
gagactcct  gggcctttg  tggaggcct  cagctctgc  gccatcttt  ttcacaact  2400
cagtggtcc  gttccagaa  ctgagtatc  gcaaaagtt  cacaaatac  taataacca  2460
aacagaaag  aatgttgca  tatatgctg  gagtgccac  tattgtctt  tgaagaatg  2520
tgtgaaaat  tttaaggat  ttggggttt  caaggagac  aaacaaaag  gagtgtctg  2580
tttagaact  agcagcact  ttctacctc  atgcaaccg  caaaaactt  tagaatata  2640
tctgagttt  gtggtgctg  aggtaacgt  tggcactgc  ggcaaatga  ggtcatgag  2700
tgagttcct  gtaggtacc  gcttctggc  caagagttg  aggtgccat  gcagggtca  2760
gcctgccct  tcccgaagt  atctcctgg  agacaagtg  cttctccct  catggatct  2820
tgatcttcc  agctctgca  caacacagc  gcctgcaga  aacacttgg  gggacctca  2880
cctctattc  caactcata  tccgtagac  acaagatga  atctcaata  attattttt  2940
agtttatta  agattgaca  tttaagtac  acttttaag  actaattac  gtgatggac  3000
cagaaatgt  gctgtgttc  ggaactgaa  cttacatgg  atacttagt  ctgctgggt  3060
atttgttgg  atattatct  gttagtggt  aatgcttcc  ttaaaaata  ttgagtcat  3120
cattcactc  ttttcagtt  tatctgtca  tagtagcta  atttttaat  ggagcacct  3180
ttatcccaa  gtgctttat  aattgagtg  actgatata  atcacaccc  ggtatcact  3240
tgctgtcct  tgctgtcag  tttagaaat  tttttaaga  ctatgtgaa  acagacaat  3300
ttagtttag  tcgggaact  agatattgt  atcaaatag  taacatcag  aagttaatt  3360
ggctggcaa  attctaggg  aacttggcc  gaaaactgg  gttgaaggc  tttgctcat  3420
taaacaagt  ccattgagt  tcaaatgac  agcaaatat  tttagaacc  ttcctgttt  3480
atgtctgta  ctcgtccac  cctcaggta  tacctgcct  tcacaggta  agctgtttc  3540
tggaaatcc  ccaaccaaa  agcagtttt  ctaacttga  tagcttgag  tgacagact  3600
ttagaatac  gttctctgg  cacagctga  gagggcttt  tgtactgca  acagattgt  3660
tactgcacc  cagtccagg  gactggtac  cactcgagt  gtgccgtgc  caacctgtc  3720
agtatatgc  tgtggtggc  ctactgact  gtaatggtt  gaggcattt  tggattttt  3780
gctttgagg  aaaaccatg  cttttaaca  atttttatg  gttatatgc  taaaccctt  3840
tgccacata  tggtaaata  ttatgaaaa  tggtctgtt  ataattggt  ggtgccttt  3900
gtgagcagg  agcataatt  ttggtttat  atggtaatt  tggtgattt  ttaaatatc  3960
tgtaatgtt  aaacgtttt  taacagttt  ctgttgctt  tctccaaga  attatggaa  4020
taagaattt  tccagatga  tgttacata  attctttga  tttagtata  aagtactga  4080
aattaagtt  gtacttcca  aagcttgga  tttaaacac  gatagtatc  catgagtaa  4140
gtgtgtttt  ggagaggga  ggatgctga  tgatatttc  cattgtatg  aataccatg  4200
ttgaaactc  tagcaataa  gctatgctg  tgtgatccc  ctcaagttc  gcatttaaa  4260
tatattttt  ctttatagg  attgatgta  accatgaag  cattgtcag  tgtagtagc  4320
ctgatgttg  atgagatat  atgttttag  attccattt  actgactag  gtagaagaa  4380
acttttctt  gctacattt  gaggatacc  agggagtct  gggtgttcc  tatctgggg  4440
agcaaacat  tcactagtc  ctttttttc  tcctttaaa  tgtaaatta  ggattactc  4500
agctcacca  tattcaaga  tgggactcg  ttcccagtc  acactctgc  ctgcctgtc  4560
ttgctgcaa  gagctgctg  tttgccaac  taagcaaag  aaatacggc  tctcttgca  4620
tattttccc  tttggttgg  ttgttttct  gaagtacgt  cagatgctt  ggggaatgc  4680
atgtatgat  tgctagctc  ctcaccact  aactcactg  gaggataaa  atgcatgct  4740
tttgtaatt  actggtgct  tgaaaatct  ttttaaggg  gaaaaatct  aaccaaagt  4800
atgctcatc  agacaagct  acctttgag  taatttcag  acaactcat  cttcagtgc  4860
tcatgactg  aaacaaaaa  caaaaaaac  aaagcatct  cacaatgaa  cttccagat  4920
gcaccgttt  gctaaaaga  acattctca  tgttttcca  cagtgatgg  ttccacata  4980
ggttaaaca  actaggtgc  tgtaaataa  ttattacag  ttactctat  gcatttctg  5040
aacatgaaa  gcatgccct  cttcagggg  agactgtgg  caagttaaa  aaaaaaaac  5100
atattaaac  acatgaaac  gcagtctgt  tttgaaaat  agaatgtcc  aagtgattc  5160
gaagagagg  gggaagttg  gcactctga  aatgcatga  aaacaaagg  aaaaactag  5220
gggaaatgt  tagaactgt  aactgagat  gcttcgagt  ttccttctg  aatctgtta  5280
atttcacaa  gtcatgagg  taaatggag  aaatatttc  gggattaca  tgaatgtaa  5340
cccaaattg  ggaattgcc  gtaacctgg  tggggaaaa  catttccca  agcactcca  5400
gtaatatga  tgctctgtg  gatgttcat  agtgtttta  agaaatggt  ttgctggga  5460
accaagttt  cacctggaa  cttacaatg  actttagcg  agtaagggc  tggcatccg  5520
tagtgaaaa  ctgtctaac  cagcattgc  caaactatt  tgacaccag  acctttttc  5580
cctttggga  acttatgaa  ctctcacta  tgtcctgtg  agaacattt  gggaaacac  5640
atgttagat  gttctttaa  gagacaaaa  ggtaatgaa  agatagcac  ggggcagaa  5700
atgcatgca  tttgtaacg  ccagtgtgg  gttgaatag  tgtgtattt  ctcccctgc  5760
gaaaataag  acagaaaat  ataatgtag  tgatcggag  tctttcctt  gatagagag  5820
acagcccca  tgatcctgg  tttttcact  aacgtatca  aatacatgg  tgaattggg  5880
taaataagg  tttaattca  atctagaag  aagtattgt  cgtttgaat  cagattttt  5940
tccacagat  gttgtagtg  ttagacatg  caggaccta  cgttgaggt  tctaagact  6000
actatgggc  gtaaacctg  tttttaaaa  tattttaga  acctgagac  tgccgtctg  6060
cattttagt  taatacaaa  taatgattg  atttgaaag  gattcttga  cttatttct  6120
aacgtctag  gctctgaaa  gtcttgatg  aaggtatta  actatttgc  tgttgtaca  6180
agaaatgtt  agactcgtg  aaagaatta  tataaggta  tgtgaaata  ctgcgattt  6240
gtgagcaaa  catacttgg  aatgctgat  gatttttat  cttgttagt  tattgcaag  6300
aacacagaa  atgtagttt  gttttaata  accaaaaat  gaacat  6346



<210> 8494
<211> 828
<212> PRT
<213> Homo sapiens
<308> XP_034422
<400> 8494

Met Asp Glu Ser Ala Leu Thr Leu Gly Thr Ile Asp Val Ser Tyr Leu 
  1               5                  10                  15
Pro His Ser Ser Glu Tyr Ser Val Gly Arg Cys Lys His Thr Ser Glu 
             20                  25                  30
Glu Trp Gly Glu Cys Gly Phe Arg Pro Thr Ile Phe Arg Ser Ala Thr 
         35                  40                  45
Leu Lys Trp Lys Glu Ser Leu Met Ser Arg Lys Arg Pro Phe Val Gly 
     50                  55                  60
Arg Cys Cys Tyr Ser Cys Thr Pro Gln Ser Trp Asp Lys Phe Phe Asn 
 65                  70                  75                  80
Pro Ser Ile Pro Ser Leu Gly Leu Arg Asn Val Ile Tyr Ile Asn Glu 
                 85                  90                  95
Thr His Thr Arg His Arg Gly Trp Leu Ala Arg Arg Leu Ser Tyr Val 
             100                105                110
Leu Phe Ile Gln Glu Arg Asp Val His Lys Gly Met Phe Ala Thr Asn 
         115                120                125
Val Thr Glu Asn Val Leu Asn Ser Ser Arg Val Gln Glu Ala Ile Ala 
     130                135                140
Glu Val Ala Ala Glu Leu Asn Pro Asp Gly Ser Ala Gln Gln Gln Ser 
 145                150                155                160
Lys Ala Val Asn Lys Val Lys Lys Lys Ala Lys Arg Ile Leu Gln Glu 
                 165                170                175
Met Val Ala Thr Val Ser Pro Ala Met Ile Arg Leu Thr Gly Trp Val 
             180                185                190
Leu Leu Lys Leu Phe Asn Ser Phe Phe Trp Asn Ile Gln Ile His Lys 
         195                200                205
Gly Gln Leu Glu Met Val Lys Ala Ala Thr Glu Thr Asn Leu Pro Leu 
     210                215                220
Leu Phe Leu Pro Val His Arg Ser His Ile Asp Tyr Leu Leu Leu Thr 
 225                230                235                240
Phe Ile Leu Phe Cys His Asn Ile Lys Ala Pro Tyr Ile Ala Ser Gly 
                 245                250                255
Asn Asn Leu Asn Ile Pro Ile Phe Ser Thr Leu Ile His Lys Leu Gly 
             260                265                270
Gly Phe Phe Ile Arg Arg Arg Leu Asp Glu Thr Pro Asp Gly Arg Lys 
         275                280                285
Asp Val Leu Tyr Arg Ala Leu Leu His Gly His Ile Val Glu Leu Leu 
     290                295                300
Arg Gln Gln Gln Phe Leu Glu Ile Phe Leu Glu Gly Thr Arg Ser Arg 
 305                310                315                320
Ser Gly Lys Thr Ser Cys Ala Arg Ala Gly Leu Leu Ser Val Val Val 
                 325                330                335
Asp Thr Leu Ser Thr Asn Val Ile Pro Asp Ile Leu Ile Ile Pro Val 
             340                345                350
Gly Ile Ser Tyr Asp Arg Ile Ile Glu Gly His Tyr Asn Gly Glu Gln 
         355                360                365
Leu Gly Lys Pro Lys Lys Asn Glu Ser Leu Trp Ser Val Ala Arg Gly 
     370                375                380
Val Ile Arg Met Leu Arg Lys Asn Tyr Gly Cys Val Arg Val Asp Phe 
 385                390                395                400
Ala Gln Pro Phe Ser Leu Lys Glu Tyr Leu Glu Ser Gln Ser Gln Lys 
                 405                410                415
Pro Val Ser Ala Leu Leu Ser Leu Glu Gln Ala Leu Leu Pro Ala Ile 
             420                425                430
Leu Pro Ser Arg Pro Ser Asp Ala Ala Asp Glu Gly Arg Asp Thr Ser 
         435                440                445
Ile Asn Glu Ser Arg Asn Ala Thr Asp Glu Ser Leu Arg Arg Arg Leu 
     450                455                460
Ile Ala Asn Leu Ala Glu His Ile Leu Phe Thr Ala Ser Lys Ser Cys 
 465                470                475                480
Ala Ile Met Ser Thr His Ile Val Ala Cys Leu Leu Leu Tyr Arg His 
                 485                490                495
Arg Gln Gly Ile Asp Leu Ser Thr Leu Val Glu Asp Phe Phe Val Met 
             500                505                510
Lys Glu Glu Val Leu Ala Arg Asp Phe Asp Leu Gly Phe Ser Gly Asn 
         515                520                525
Ser Glu Asp Val Val Met His Ala Ile Gln Leu Leu Gly Asn Cys Val 
     530                535                540
Thr Ile Thr His Thr Ser Arg Asn Asp Glu Phe Phe Ile Thr Pro Ser 
 545                550                555                560
Thr Thr Val Pro Ser Val Phe Glu Leu Asn Phe Tyr Ser Asn Gly Val 
                 565                570                575
Leu His Val Phe Ile Met Glu Ala Ile Ile Ala Cys Ser Leu Tyr Ala 
             580                585                590
Val Leu Asn Lys Arg Gly Leu Gly Gly Pro Thr Ser Thr Pro Pro Asn 
         595                600                605
Leu Ile Ser Gln Glu Gln Leu Val Arg Lys Ala Ala Ser Leu Cys Tyr 
     610                615                620
Leu Leu Ser Asn Glu Gly Thr Ile Ser Leu Pro Cys Gln Thr Phe Tyr 
 625                630                635                640
Gln Val Cys His Glu Thr Val Gly Lys Phe Ile Gln Tyr Gly Ile Leu 
                 645                650                655
Thr Val Ala Glu His Asp Asp Gln Glu Asp Ile Ser Pro Ser Leu Ala 
             660                665                670
Glu Gln Gln Trp Asp Lys Lys Leu Pro Glu Pro Leu Ser Trp Arg Ser 
         675                680                685
Asp Glu Glu Asp Glu Asp Ser Asp Phe Gly Glu Glu Gln Arg Asp Cys 
     690                695                700
Tyr Leu Lys Val Ser Gln Ser Lys Glu His Gln Gln Phe Ile Thr Phe 
 705                710                715                720
Leu Gln Arg Leu Leu Gly Pro Leu Leu Glu Ala Tyr Ser Ser Ala Ala 
                 725                730                735
Ile Phe Val His Asn Phe Ser Gly Pro Val Pro Glu Pro Glu Tyr Leu 
             740                745                750
Gln Lys Leu His Lys Tyr Leu Ile Thr Arg Thr Glu Arg Asn Val Ala 
         755                760                765
Val Tyr Ala Glu Ser Ala Thr Tyr Cys Leu Val Lys Asn Ala Val Lys 
     770                775                780
Met Phe Lys Asp Ile Gly Val Phe Lys Glu Thr Lys Gln Lys Arg Val 
 785                790                795                800
Ser Val Leu Glu Leu Ser Ser Thr Phe Leu Pro Gln Cys Asn Arg Gln 
                 805                810                815
Lys Leu Leu Glu Tyr Ile Leu Ser Phe Val Val Leu 
             820                825



<210> 8495
<211> 2519
<212> DNA
<213> Rattus norvegicus
<308> U36772
<400> 8495

cagccttgg  cgatgtaaa  acacgaatg  ggactgggt  gactttggc  tcaaaccta  60
cttcttcag  tccgcaacg  tgaaatgga  ggagagcct  atgagccgg  agaggccct  120
cgtgggaag  tgttgctat  catgcacgc  tcagagctg  gaaaggttc  tcaacccca  180
tatcccacc  ctgggtttg  ggaatgtta  ttatatcaa  gaaactcac  caaggcacc  240
aggatggct  gcaagacgg  tttcttaca  cctttttgt  caagagcgc  atgtccaca  300
gggcatgtt  gccaccagt  tcactgaca  tgtactgaa  agcagcaga  tccaagagg  360
aattgctga  gtggctgca  aattgaacc  ggatggatc  gcccagcag  agtccaaag  420
catccagaa  gtgaaaagg  aagccagga  gatcctcca  gaaatggtt  ctacagtct  480
ccccgggat  atcaggctg  ctggctggg  gttactaaa  ctcttcaac  gcttcttct  540
gaacattca  attcacaag  gtcaacttg  gatggtgaa  gctgcaact  agacgaatc  600
gccgctctt  tttctgccg  tgcacagat  ccacatcga  tacctgttg  tcaccttca  660
cctcttctg  cacaacatc  aagctccat  catcgcctc  ggcaacaac  tcaacatcc  720
catcttcag  accttgatt  acaagcttg  gggcttttt  ataagacgg  ggcttgacg  780
aactccaga  ggacgcaaa  acattctgt  cagagcgtt  ctccatggg  atgtagttg  840
actcctccg  cagcagcag  tcctggaga  cttcctgga  ggcacccgc  cccgcagtg  900
caagacctc  tgtgcccgg  ccggcgtcc  gtcagtggt  gtggatact  tgtcatcca  960
caccatccc  gacatcctg  tcatccctg  gggcatctc  tatgatcgg  taatcgaag  1020
tcactacaa  ggtgaacag  tgggcaagc  caagaagaa  gaaagtctc  ggagtgtgg  1080
aagaggcgt  atcagaatg  tgcggaaaa  ctacggcta  gtccgagtg  actttgcac  1140
gccattttc  ttgaaggaa  atttagaag  ccaaagtca  aaacctgta  ctgctcccc  1200
ctctttgga  caagcactg  taccagcaa  ccttccttc  agacctgat  ctgctgctg  1260
cgaacatga  gacatgtcc  gtaatgagt  gagaaacgc  gcagacgaa  ccttccgaa  1320
gaggctgat  gcaaacctg  cggagcaca  tctcctcac  gccagcaag  cctgcgcta  1380
catgtccac  cacattgtg  cctgcctgc  cctctacag  cactggcag  gaatccacc  1440
ctccacgct  gtggaagac  tctttgtga  gaaggagga  gtcctagct  gggattttg  1500
cctgggctt  tccgggaat  cagaagacg  agtcatgca  gctattcag  ttctgggca  1560
ctgtgtcac  atcacccac  ctagcagga  ggatgaatt  tttattact  ccagcacaa  1620
tgtcccgtc  gtctttgaa  tcaacttct  cagcaatgg  gtacttcat  tctttatca  1680
ggaagccat  atagcttgc  gcatttatg  agtccagaa  aagaggggt  ccggaggtc  1740
gccggagcc  ggcaacctg  tcagccagg  gcagctggt  cggaaggcc  ccagcctgt  1800
ctaccttct  tctaatgaa  gtaccattt  tctgccctg  cagacattt  accaggttt  1860
tcacgagac  gtaggaaag  tcatccagt  cggaattct  acagtggca  agcaagatg  1920
ccaggaaga  gtcagtcct  gccttgcag  gcagcagtg  aacaagaag  ttccggagc  1980
tctgaactg  agaagtgac  aagaagatg  ggacagtga  tttggtgag  agcagcgtg  2040
ttgctacct  aaggtgagc  aggccaagg  gcaccagca  ttcatcacc  ttctgcaga  2100
gcttctggg  cccctgcta  aagcctaca  ctctgctgc  atctttgtc  acaccttcc  2160
cgcgccagt  cccgagtct  agtacctgc  gaagctgca  aggtacctt  tcaccagga  2220
ggagaggaa  gtcgcggtg  acgctgaga  tgccacata  tgtcttgtg  agaatgctg  2280
gaaaatgtt  aaggacatc  gggttttca  agagaccaa  cagaagcga  cgtctgtct  2340
agaactgag  accactttc  tacctcagg  cagccggca  aagctcctg  aatacattc  2400
gagcttcgt  gtgctgtag  gttccctca  cacctatct  cgtgaggag  tgatgagtc  2460
tttgcagac  ccagtctga  ccagagtgg  aagtttcct  gacatgggc  agcctgccg  2519



<210> 8496
<211> 828
<212> PRT
<213> Rattus norvegicus
<308> AAB39470
<400> 8496

Met Glu Glu Ser Ser Val Thr Ile Gly Thr Ile Asp Val Ser Tyr Leu 
  1               5                  10                  15
Pro Asn Ser Ser Glu Tyr Ser Leu Gly Arg Cys Lys His Thr Asn Glu 
             20                  25                  30
Asp Trp Val Asp Cys Gly Phe Lys Pro Thr Phe Phe Arg Ser Ala Thr 
         35                  40                  45
Leu Lys Trp Lys Glu Ser Leu Met Ser Arg Lys Arg Pro Phe Val Gly 
     50                  55                  60
Arg Cys Cys Tyr Ser Cys Thr Pro Gln Ser Trp Glu Arg Phe Phe Asn 
 65                  70                  75                  80
Pro Ser Ile Pro Ser Leu Gly Leu Arg Asn Val Ile Tyr Ile Asn Glu 
                 85                  90                  95
Thr His Thr Arg His Arg Gly Trp Leu Ala Arg Arg Leu Ser Tyr Ile 
             100                105                110
Leu Phe Val Gln Glu Arg Asp Val His Lys Gly Met Phe Ala Thr Ser 
         115                120                125
Ile Thr Asp Asn Val Leu Asn Ser Ser Arg Val Gln Glu Ala Ile Ala 
     130                135                140
Glu Val Ala Ala Glu Leu Asn Pro Asp Gly Ser Ala Gln Gln Gln Ser 
 145                150                155                160
Lys Ala Ile Gln Lys Val Lys Arg Lys Ala Arg Lys Ile Leu Gln Glu 
                 165                170                175
Met Val Ala Thr Val Ser Pro Gly Met Ile Arg Leu Thr Gly Trp Val 
             180                185                190
Leu Leu Lys Leu Phe Asn Ser Phe Phe Trp Asn Ile Gln Ile His Lys 
         195                200                205
Gly Gln Leu Glu Met Val Lys Ala Ala Thr Glu Thr Asn Leu Pro Leu 
     210                215                220
Leu Phe Leu Pro Val His Arg Ser His Ile Asp Tyr Leu Leu Leu Thr 
 225                230                235                240
Phe Ile Leu Phe Cys His Asn Ile Lys Ala Pro Tyr Ile Ala Ser Gly 
                 245                250                255
Asn Asn Leu Asn Ile Pro Ile Phe Ser Thr Leu Ile His Lys Leu Gly 
             260                265                270
Gly Phe Phe Ile Arg Arg Arg Leu Asp Glu Thr Pro Asp Gly Arg Lys 
         275                280                285
Asp Ile Leu Tyr Arg Ala Leu Leu His Gly His Ile Val Glu Leu Leu 
     290                295                300
Arg Gln Gln Gln Phe Leu Glu Ile Phe Leu Glu Gly Thr Arg Ser Arg 
 305                310                315                320
Ser Gly Lys Thr Ser Cys Ala Arg Ala Gly Leu Leu Ser Val Val Val 
                 325                330                335
Asp Thr Leu Ser Ser Asn Thr Ile Pro Asp Ile Leu Val Ile Pro Val 
             340                345                350
Gly Ile Ser Tyr Asp Arg Ile Ile Glu Gly His Tyr Asn Gly Glu Gln 
         355                360                365
Leu Gly Lys Pro Lys Lys Asn Glu Ser Leu Trp Ser Val Ala Arg Gly 
     370                375                380
Val Ile Arg Met Leu Arg Lys Asn Tyr Gly Tyr Val Arg Val Asp Phe 
 385                390                395                400
Ala Gln Pro Phe Ser Leu Lys Glu Tyr Leu Glu Gly Gln Ser Gln Lys 
                 405                410                415
Pro Val Ser Ala Pro Leu Ser Leu Glu Gln Ala Leu Leu Pro Ala Ile 
             420                425                430
Leu Pro Ser Arg Pro Asp Ala Ala Ala Ala Glu His Glu Asp Met Ser 
         435                440                445
Ser Asn Glu Ser Arg Asn Ala Ala Asp Glu Ala Phe Arg Arg Arg Leu 
     450                455                460
Ile Ala Asn Leu Ala Glu His Ile Leu Phe Thr Ala Ser Lys Ser Cys 
 465                470                475                480
Ala Ile Met Ser Thr His Ile Val Ala Cys Leu Leu Leu Tyr Arg His 
                 485                490                495
Arg Gln Gly Ile His Leu Ser Thr Leu Val Glu Asp Phe Phe Val Met 
             500                505                510
Lys Glu Glu Val Leu Ala Arg Asp Phe Asp Leu Gly Phe Ser Gly Asn 
         515                520                525
Ser Glu Asp Val Val Met His Ala Ile Gln Leu Leu Gly Asn Cys Val 
     530                535                540
Thr Ile Thr His Thr Ser Arg Lys Asp Glu Phe Phe Ile Thr Pro Ser 
 545                550                555                560
Thr Thr Val Pro Ser Val Phe Glu Leu Asn Phe Tyr Ser Asn Gly Val 
                 565                570                575
Leu His Val Phe Ile Met Glu Ala Ile Ile Ala Cys Ser Ile Tyr Ala 
             580                585                590
Val Gln Asn Lys Arg Gly Ser Gly Gly Ser Ala Gly Gly Leu Gly Asn 
         595                600                605
Leu Ile Ser Gln Glu Gln Leu Val Arg Lys Ala Ala Ser Leu Cys Tyr 
     610                615                620
Leu Leu Ser Asn Glu Gly Thr Ile Ser Leu Pro Cys Gln Thr Phe Tyr 
 625                630                635                640
Gln Val Cys Gln Glu Thr Val Gly Lys Phe Ile Gln Tyr Gly Ile Leu 
                 645                650                655
Thr Val Ala Glu Gln Asp Asp Gln Glu Asp Val Ser Pro Gly Leu Ala 
             660                665                670
Glu Gln Gln Trp Asn Lys Lys Leu Pro Glu Pro Leu Asn Trp Arg Ser 
         675                680                685
Asp Glu Glu Asp Glu Asp Ser Asp Phe Gly Glu Glu Gln Arg Asp Cys 
     690                695                700
Tyr Leu Lys Val Ser Gln Ala Lys Glu His Gln Gln Phe Ile Thr Phe 
 705                710                715                720
Leu Gln Arg Leu Leu Gly Pro Leu Leu Glu Ala Tyr Ser Ser Ala Ala 
                 725                730                735
Ile Phe Val His Thr Phe Arg Gly Pro Val Pro Glu Ser Glu Tyr Leu 
             740                745                750
Gln Lys Leu His Arg Tyr Leu Leu Thr Arg Thr Glu Arg Asn Val Ala 
         755                760                765
Val Tyr Ala Glu Ser Ala Thr Tyr Cys Leu Val Lys Asn Ala Val Lys 
     770                775                780
Met Phe Lys Asp Ile Gly Val Phe Lys Glu Thr Lys Gln Lys Arg Ala 
 785                790                795                800
Ser Val Leu Glu Leu Ser Thr Thr Phe Leu Pro Gln Gly Ser Arg Gln 
                 805                810                815
Lys Leu Leu Glu Tyr Ile Leu Ser Phe Val Val Leu 
             820                825



<210> 8497
<211> 6346
<212> DNA
<213> Homo sapiens
<308> XM_034422
<400> 8497

ggactggaa  tgcgggctt  tgcagcagc  gaagctgga  ctgctaggg  agcagcggc  60
cccctgttg  atggacatt  tgcacccga  actgatagc  gagtcctga  gttttatgt  120
atgaaacag  agaactttc  tcccagcac  tgatttggg  attacactt  gtgacatgg  180
tgaatctgc  ctgaccctt  gtacaatag  tgtttctta  ctgccacat  catcagaat  240
cagtgttgg  cgatgtaag  acacaagtg  ggaatgggg  gagtgtggc  ttagaccca  300
catcttcag  tctgcaact  taaaatgga  agaaagcct  atgagtcgg  aaaggccat  360
tgttggaag  tgttgttac  cctgcactc  ccagagctg  gacaaattt  tcaacccca  420
tatcccgtc  ttgggtttg  ggaatgtta  ttatatcaa  gaaactcac  caagacacc  480
cggatggct  gcaagacgc  tttcttacg  tctttttat  caagagcga  atgtgcata  540
gggcatgtt  gccaccaat  tgactgaaa  tgtgctgaa  agcagtaga  tacaagagg  600
aattgcaga  gtggctgct  aattaaacc  tgatggttc  gcccagcag  aatcaaaag  660
cgttaacaa  gtgaaaaag  aagctaaaa  gattcttca  gaaatggtt  ccactgtct  720
accggcaat  atcagactg  ctgggtggg  gctgctaaa  ctgttcaac  gcttctttt  780
gaacattca  attcacaaa  gtcaacttg  gatggttaa  gctgcaact  agacgaatt  840
gccgcttct  tttctacca  ttcatagat  ccatattga  tatctgctg  tcactttca  900
tctcttctg  cataacatc  aagcaccat  cattgcttc  ggcaataat  tcaacatcc  960
aatcttcag  accttgatc  ataagcttg  gggcttctt  atacgacga  ggctcgatg  1020
aacaccaga  ggacggaaa  atgttctct  tagagcttt  ctccatggg  atatagttg  1080
attacttcg  cagcagcaa  tcttggaga  cttcctgga  ggcacacgt  ctaggagtg  1140
aaaaacctc  tgtgctcgg  caggacttt  gtcagttgt  gtagatact  tgtctacca  1200
tgtcatccc  gacatcttg  taatacctg  tggaatctc  tatgatcgc  ttatcgaag  1260
tcactacaa  ggtgaacaa  tgggcaaac  taagaagaa  gagagcctg  ggagtgtag  1320
aagaggtgt  attagaatg  tacgaaaaa  ctatggttg  gtccgagtg  attttgcac  1380
gccattttc  ttaaaggaa  atttagaaa  ccaaagtca  aaaccggtg  ctgctctac  1440
ttccctgga  caagcgttg  taccagcta  acttccttc  agacccagt  atgctgctg  1500
tgaaggtag  gacacgtcc  ttaatgagt  cagaaatgc  acagatgaa  ccctacgaa  1560
gaggttgat  gcaaatctg  ctgagcata  tctattcac  gctagcaag  cctgtgcca  1620
tatgtccac  cacattgtg  cttgcctgc  cctctacag  cacaggcag  gaattgatc  1680
ctccacatt  gtcgaagac  tctttgtga  gaaagagga  gtcctggct  gtgattttg  1740
cctggggtt  tcaggaaat  cagaagatg  agtaatgca  gccatacag  tgctgggaa  1800
ttgtgtcac  atcacccac  ctagcagga  cgatgagtt  tttatcacc  ccagcacaa  1860
tgtcccatc  gtcttcgaa  tcaacttct  cagcaatgg  gtacttcat  tctttatca  1920
ggaggccat  atagcttgc  gcctttatg  agttctgaa  aagagggga  tggggggtc  1980
cactagcac  ccacctaac  tgatcagcc  ggagcagct  gtgcggaag  cggccagcc  2040
gtgctacct  ctctccaat  aaggcacca  ctcactgcc  tgccagaca  tttaccaag  2100
ctgccatga  acagtagga  agtttatcc  gtatggcat  cttacagtg  cagagcacg  2160
tgaccagga  gatatcagt  ctagtcttg  tgagcagca  tgggacaag  agcttccag  2220
acctttgtc  tggagaagt  atgaagaag  tgaagacag  gactttggg  aggaacagc  2280
agattgcta  ctgaaggtg  gccaatcca  ggagcacca  cagtttatc  ccttcttac  2340
gagactcct  gggcctttg  tggaggcct  cagctctgc  gccatcttt  ttcacaact  2400
cagtggtcc  gttccagaa  ctgagtatc  gcaaaagtt  cacaaatac  taataacca  2460
aacagaaag  aatgttgca  tatatgctg  gagtgccac  tattgtctt  tgaagaatg  2520
tgtgaaaat  tttaaggat  ttggggttt  caaggagac  aaacaaaag  gagtgtctg  2580
tttagaact  agcagcact  ttctacctc  atgcaaccg  caaaaactt  tagaatata  2640
tctgagttt  gtggtgctg  aggtaacgt  tggcactgc  ggcaaatga  ggtcatgag  2700
tgagttcct  gtaggtacc  gcttctggc  caagagttg  aggtgccat  gcagggtca  2760
gcctgccct  tcccgaagt  atctcctgg  agacaagtg  cttctccct  catggatct  2820
tgatcttcc  agctctgca  caacacagc  gcctgcaga  aacacttgg  gggacctca  2880
cctctattc  caactcata  tccgtagac  acaagatga  atctcaata  attattttt  2940
agtttatta  agattgaca  tttaagtac  acttttaag  actaattac  gtgatggac  3000
cagaaatgt  gctgtgttc  ggaactgaa  cttacatgg  atacttagt  ctgctgggt  3060
atttgttgg  atattatct  gttagtggt  aatgcttcc  ttaaaaata  ttgagtcat  3120
cattcactc  ttttcagtt  tatctgtca  tagtagcta  atttttaat  ggagcacct  3180
ttatcccaa  gtgctttat  aattgagtg  actgatata  atcacaccc  ggtatcact  3240
tgctgtcct  tgctgtcag  tttagaaat  tttttaaga  ctatgtgaa  acagacaat  3300
ttagtttag  tcgggaact  agatattgt  atcaaatag  taacatcag  aagttaatt  3360
ggctggcaa  attctaggg  aacttggcc  gaaaactgg  gttgaaggc  tttgctcat  3420
taaacaagt  ccattgagt  tcaaatgac  agcaaatat  tttagaacc  ttcctgttt  3480
atgtctgta  ctcgtccac  cctcaggta  tacctgcct  tcacaggta  agctgtttc  3540
tggaaatcc  ccaaccaaa  agcagtttt  ctaacttga  tagcttgag  tgacagact  3600
ttagaatac  gttctctgg  cacagctga  gagggcttt  tgtactgca  acagattgt  3660
tactgcacc  cagtccagg  gactggtac  cactcgagt  gtgccgtgc  caacctgtc  3720
agtatatgc  tgtggtggc  ctactgact  gtaatggtt  gaggcattt  tggattttt  3780
gctttgagg  aaaaccatg  cttttaaca  atttttatg  gttatatgc  taaaccctt  3840
tgccacata  tggtaaata  ttatgaaaa  tggtctgtt  ataattggt  ggtgccttt  3900
gtgagcagg  agcataatt  ttggtttat  atggtaatt  tggtgattt  ttaaatatc  3960
tgtaatgtt  aaacgtttt  taacagttt  ctgttgctt  tctccaaga  attatggaa  4020
taagaattt  tccagatga  tgttacata  attctttga  tttagtata  aagtactga  4080
aattaagtt  gtacttcca  aagcttgga  tttaaacac  gatagtatc  catgagtaa  4140
gtgtgtttt  ggagaggga  ggatgctga  tgatatttc  cattgtatg  aataccatg  4200
ttgaaactc  tagcaataa  gctatgctg  tgtgatccc  ctcaagttc  gcatttaaa  4260
tatattttt  ctttatagg  attgatgta  accatgaag  cattgtcag  tgtagtagc  4320
ctgatgttg  atgagatat  atgttttag  attccattt  actgactag  gtagaagaa  4380
acttttctt  gctacattt  gaggatacc  agggagtct  gggtgttcc  tatctgggg  4440
agcaaacat  tcactagtc  ctttttttc  tcctttaaa  tgtaaatta  ggattactc  4500
agctcacca  tattcaaga  tgggactcg  ttcccagtc  acactctgc  ctgcctgtc  4560
ttgctgcaa  gagctgctg  tttgccaac  taagcaaag  aaatacggc  tctcttgca  4620
tattttccc  tttggttgg  ttgttttct  gaagtacgt  cagatgctt  ggggaatgc  4680
atgtatgat  tgctagctc  ctcaccact  aactcactg  gaggataaa  atgcatgct  4740
tttgtaatt  actggtgct  tgaaaatct  ttttaaggg  gaaaaatct  aaccaaagt  4800
atgctcatc  agacaagct  acctttgag  taatttcag  acaactcat  cttcagtgc  4860
tcatgactg  aaacaaaaa  caaaaaaac  aaagcatct  cacaatgaa  cttccagat  4920
gcaccgttt  gctaaaaga  acattctca  tgttttcca  cagtgatgg  ttccacata  4980
ggttaaaca  actaggtgc  tgtaaataa  ttattacag  ttactctat  gcatttctg  5040
aacatgaaa  gcatgccct  cttcagggg  agactgtgg  caagttaaa  aaaaaaaac  5100
atattaaac  acatgaaac  gcagtctgt  tttgaaaat  agaatgtcc  aagtgattc  5160
gaagagagg  gggaagttg  gcactctga  aatgcatga  aaacaaagg  aaaaactag  5220
gggaaatgt  tagaactgt  aactgagat  gcttcgagt  ttccttctg  aatctgtta  5280
atttcacaa  gtcatgagg  taaatggag  aaatatttc  gggattaca  tgaatgtaa  5340
cccaaattg  ggaattgcc  gtaacctgg  tggggaaaa  catttccca  agcactcca  5400
gtaatatga  tgctctgtg  gatgttcat  agtgtttta  agaaatggt  ttgctggga  5460
accaagttt  cacctggaa  cttacaatg  actttagcg  agtaagggc  tggcatccg  5520
tagtgaaaa  ctgtctaac  cagcattgc  caaactatt  tgacaccag  acctttttc  5580
cctttggga  acttatgaa  ctctcacta  tgtcctgtg  agaacattt  gggaaacac  5640
atgttagat  gttctttaa  gagacaaaa  ggtaatgaa  agatagcac  ggggcagaa  5700
atgcatgca  tttgtaacg  ccagtgtgg  gttgaatag  tgtgtattt  ctcccctgc  5760
gaaaataag  acagaaaat  ataatgtag  tgatcggag  tctttcctt  gatagagag  5820
acagcccca  tgatcctgg  tttttcact  aacgtatca  aatacatgg  tgaattggg  5880
taaataagg  tttaattca  atctagaag  aagtattgt  cgtttgaat  cagattttt  5940
tccacagat  gttgtagtg  ttagacatg  caggaccta  cgttgaggt  tctaagact  6000
actatgggc  gtaaacctg  tttttaaaa  tattttaga  acctgagac  tgccgtctg  6060
cattttagt  taatacaaa  taatgattg  atttgaaag  gattcttga  cttatttct  6120
aacgtctag  gctctgaaa  gtcttgatg  aaggtatta  actatttgc  tgttgtaca  6180
agaaatgtt  agactcgtg  aaagaatta  tataaggta  tgtgaaata  ctgcgattt  6240
gtgagcaaa  catacttgg  aatgctgat  gatttttat  cttgttagt  tattgcaag  6300
aacacagaa  atgtagttt  gttttaata  accaaaaat  gaacat  6346



<210> 8498
<211> 828
<212> PRT
<213> Homo sapiens
<308> XP_034422
<400> 8498

Met Asp Glu Ser Ala Leu Thr Leu Gly Thr Ile Asp Val Ser Tyr Leu 
  1               5                  10                  15
Pro His Ser Ser Glu Tyr Ser Val Gly Arg Cys Lys His Thr Ser Glu 
             20                  25                  30
Glu Trp Gly Glu Cys Gly Phe Arg Pro Thr Ile Phe Arg Ser Ala Thr 
         35                  40                  45
Leu Lys Trp Lys Glu Ser Leu Met Ser Arg Lys Arg Pro Phe Val Gly 
     50                  55                  60
Arg Cys Cys Tyr Ser Cys Thr Pro Gln Ser Trp Asp Lys Phe Phe Asn 
 65                  70                  75                  80
Pro Ser Ile Pro Ser Leu Gly Leu Arg Asn Val Ile Tyr Ile Asn Glu 
                 85                  90                  95
Thr His Thr Arg His Arg Gly Trp Leu Ala Arg Arg Leu Ser Tyr Val 
             100                105                110
Leu Phe Ile Gln Glu Arg Asp Val His Lys Gly Met Phe Ala Thr Asn 
         115                120                125
Val Thr Glu Asn Val Leu Asn Ser Ser Arg Val Gln Glu Ala Ile Ala 
     130                135                140
Glu Val Ala Ala Glu Leu Asn Pro Asp Gly Ser Ala Gln Gln Gln Ser 
 145                150                155                160
Lys Ala Val Asn Lys Val Lys Lys Lys Ala Lys Arg Ile Leu Gln Glu 
                 165                170                175
Met Val Ala Thr Val Ser Pro Ala Met Ile Arg Leu Thr Gly Trp Val 
             180                185                190
Leu Leu Lys Leu Phe Asn Ser Phe Phe Trp Asn Ile Gln Ile His Lys 
         195                200                205
Gly Gln Leu Glu Met Val Lys Ala Ala Thr Glu Thr Asn Leu Pro Leu 
     210                215                220
Leu Phe Leu Pro Val His Arg Ser His Ile Asp Tyr Leu Leu Leu Thr 
 225                230                235                240
Phe Ile Leu Phe Cys His Asn Ile Lys Ala Pro Tyr Ile Ala Ser Gly 
                 245                250                255
Asn Asn Leu Asn Ile Pro Ile Phe Ser Thr Leu Ile His Lys Leu Gly 
             260                265                270
Gly Phe Phe Ile Arg Arg Arg Leu Asp Glu Thr Pro Asp Gly Arg Lys 
         275                280                285
Asp Val Leu Tyr Arg Ala Leu Leu His Gly His Ile Val Glu Leu Leu 
     290                295                300
Arg Gln Gln Gln Phe Leu Glu Ile Phe Leu Glu Gly Thr Arg Ser Arg 
 305                310                315                320
Ser Gly Lys Thr Ser Cys Ala Arg Ala Gly Leu Leu Ser Val Val Val 
                 325                330                335
Asp Thr Leu Ser Thr Asn Val Ile Pro Asp Ile Leu Ile Ile Pro Val 
             340                345                350
Gly Ile Ser Tyr Asp Arg Ile Ile Glu Gly His Tyr Asn Gly Glu Gln 
         355                360                365
Leu Gly Lys Pro Lys Lys Asn Glu Ser Leu Trp Ser Val Ala Arg Gly 
     370                375                380
Val Ile Arg Met Leu Arg Lys Asn Tyr Gly Cys Val Arg Val Asp Phe 
 385                390                395                400
Ala Gln Pro Phe Ser Leu Lys Glu Tyr Leu Glu Ser Gln Ser Gln Lys 
                 405                410                415
Pro Val Ser Ala Leu Leu Ser Leu Glu Gln Ala Leu Leu Pro Ala Ile 
             420                425                430
Leu Pro Ser Arg Pro Ser Asp Ala Ala Asp Glu Gly Arg Asp Thr Ser 
         435                440                445
Ile Asn Glu Ser Arg Asn Ala Thr Asp Glu Ser Leu Arg Arg Arg Leu 
     450                455                460
Ile Ala Asn Leu Ala Glu His Ile Leu Phe Thr Ala Ser Lys Ser Cys 
 465                470                475                480
Ala Ile Met Ser Thr His Ile Val Ala Cys Leu Leu Leu Tyr Arg His 
                 485                490                495
Arg Gln Gly Ile Asp Leu Ser Thr Leu Val Glu Asp Phe Phe Val Met 
             500                505                510
Lys Glu Glu Val Leu Ala Arg Asp Phe Asp Leu Gly Phe Ser Gly Asn 
         515                520                525
Ser Glu Asp Val Val Met His Ala Ile Gln Leu Leu Gly Asn Cys Val 
     530                535                540
Thr Ile Thr His Thr Ser Arg Asn Asp Glu Phe Phe Ile Thr Pro Ser 
 545                550                555                560
Thr Thr Val Pro Ser Val Phe Glu Leu Asn Phe Tyr Ser Asn Gly Val 
                 565                570                575
Leu His Val Phe Ile Met Glu Ala Ile Ile Ala Cys Ser Leu Tyr Ala 
             580                585                590
Val Leu Asn Lys Arg Gly Leu Gly Gly Pro Thr Ser Thr Pro Pro Asn 
         595                600                605
Leu Ile Ser Gln Glu Gln Leu Val Arg Lys Ala Ala Ser Leu Cys Tyr 
     610                615                620
Leu Leu Ser Asn Glu Gly Thr Ile Ser Leu Pro Cys Gln Thr Phe Tyr 
 625                630                635                640
Gln Val Cys His Glu Thr Val Gly Lys Phe Ile Gln Tyr Gly Ile Leu 
                 645                650                655
Thr Val Ala Glu His Asp Asp Gln Glu Asp Ile Ser Pro Ser Leu Ala 
             660                665                670
Glu Gln Gln Trp Asp Lys Lys Leu Pro Glu Pro Leu Ser Trp Arg Ser 
         675                680                685
Asp Glu Glu Asp Glu Asp Ser Asp Phe Gly Glu Glu Gln Arg Asp Cys 
     690                695                700
Tyr Leu Lys Val Ser Gln Ser Lys Glu His Gln Gln Phe Ile Thr Phe 
 705                710                715                720
Leu Gln Arg Leu Leu Gly Pro Leu Leu Glu Ala Tyr Ser Ser Ala Ala 
                 725                730                735
Ile Phe Val His Asn Phe Ser Gly Pro Val Pro Glu Pro Glu Tyr Leu 
             740                745                750
Gln Lys Leu His Lys Tyr Leu Ile Thr Arg Thr Glu Arg Asn Val Ala 
         755                760                765
Val Tyr Ala Glu Ser Ala Thr Tyr Cys Leu Val Lys Asn Ala Val Lys 
     770                775                780
Met Phe Lys Asp Ile Gly Val Phe Lys Glu Thr Lys Gln Lys Arg Val 
 785                790                795                800
Ser Val Leu Glu Leu Ser Ser Thr Phe Leu Pro Gln Cys Asn Arg Gln 
                 805                810                815
Lys Leu Leu Glu Tyr Ile Leu Ser Phe Val Val Leu 
             820                825



<210> 8499
<211> 1305
<212> DNA
<213> Rattus norvegicus
<308> U36895
<400> 8499

ggcacgagc  gtgattaag  gactttgaa  ttttcaagg  atttggagt  ttatgaaga  60
tttgaagat  tacagagtt  acaggaatg  agctgacca  ccactatga  atgccttat  120
tctccaaga  cataaatat  aggcatggc  tgagaggac  agcagccac  gttctcata  180
atgatgaat  agaacagca  agtccacac  gattctacc  taaggaata  cttctccac  240
gaaattggc  ttggaatct  agccaacag  ttcctactt  tcttccaca  cttcaagtt  300
attcgtgga  agaggtcca  actcactga  ctgcccatt  gtctcttgt  cctaatcca  360
ctactgatg  tactgatgg  ggcattcat  gccatagac  tttttattt  ttggagggg  420
tgggatgac  tcatatgta  attccttgt  tacttgtac  gaagtttta  aggtctctc  480
ctttgtacc  cctgcatgt  gagtgtcct  caggccatc  ccctcagcc  cagaagctc  540
tgtttagca  agttcaaac  taagtctcc  catcacgtc  cctgtgcca  tatttcgct  600
agcatcctc  acatgttca  tagcagtca  ctcttagta  ccatcaatg  cacccccaa  660
ttgaccacg  acaacttta  gcaagttac  cagtcctgc  acattatac  cttgagtta  720
ctcatgcaa  gcatgtttt  tacacttct  gccatcaga  atatctctc  tattagtct  780
atggtcctc  cgacttgtt  catggaggt  ctcttgtgt  ggcacagga  tcagatcca  840
catcttcaa  ggaccaacc  ttccccaaa  gcatctcca  aacaaaggg  cacacagac  900
atcctgatg  tcatgacct  ctttgtcct  atgtccatt  tcgacagca  tgtctcctg  960
tcaagaact  tgtatctga  tgatccaac  tcttactat  ttcaaatat  tgtagtgga  1020
atctatgcc  cagtcagcc  ttttgtgtt  atgagcact  gaaaacata  agttaactt  1080
ttgaagtcc  tgtgtgtga  ggtgaagaa  gtttgaata  tcattaatg  acaagatcc  1140
ttaagagga  ccaatgtag  catcagaac  gtcagtcat  gtgtgctgt  tatgtgctt  1200
ggtaaatgt  aatcatgaa  ttgtttttc  ggtaaaatg  tttacttta  ccaactcat  1260
attgtaaac  tgtaacagg  gattaaaca  tatcccctt  ggaaa  1305



<210> 8500
<211> 312
<212> PRT
<213> Rattus norvegicus
<308> U36895
<400> 8500

Met Met Asn Lys Asn Ser Arg Val His Thr Asp Ser Thr Ile Arg Asn 
  1               5                  10                  15
Thr Phe Ser Thr Glu Ile Gly Ile Gly Ile Leu Ala Asn Ser Phe Leu 
             20                  25                  30
Leu Leu Phe His Ile Phe Lys Phe Ile Arg Gly Gln Arg Ser Arg Leu 
         35                  40                  45
Thr Asp Leu Pro Ile Gly Leu Leu Ser Leu Ile His Leu Leu Met Leu 
     50                  55                  60
Leu Met Gly Ala Phe Ile Ala Ile Asp Ile Phe Ile Ser Trp Arg Gly 
 65                  70                  75                  80
Trp Asp Asp Ile Ile Cys Lys Phe Leu Val Tyr Leu Tyr Arg Ser Phe 
                 85                  90                  95
Arg Gly Leu Ser Leu Cys Thr Thr Cys Met Leu Ser Val Leu Gln Ala 
             100                105                110
Ile Thr Leu Ser Pro Arg Ser Ser Cys Leu Ala Lys Phe Lys His Lys 
         115                120                125
Ser Pro His His Val Ser Cys Ala Ile Ile Ser Leu Ser Ile Leu Tyr 
     130                135                140
Met Phe Ile Ser Ser His Leu Leu Val Ser Ile Asn Ala Thr Pro Asn 
 145                150                155                160
Leu Thr Thr Asn Asn Phe Met Gln Val Thr Gln Ser Cys Tyr Ile Ile 
                 165                170                175
Pro Leu Ser Tyr Leu Met Gln Ser Met Phe Ser Thr Leu Leu Ala Ile 
             180                185                190
Arg Asp Ile Ser Leu Ile Ser Leu Met Val Leu Ser Thr Cys Tyr Met 
         195                200                205
Glu Val Leu Leu Cys Arg His Arg Asn Gln Ile Gln His Leu Gln Gly 
     210                215                220
Thr Asn Leu Ser Pro Lys Ala Ser Pro Glu Gln Arg Ala Thr Gln Thr 
 225                230                235                240
Ile Leu Met Leu Met Thr Phe Phe Val Leu Met Ser Ile Phe Asp Ser 
                 245                250                255
Ile Val Ser Cys Ser Arg Thr Met Tyr Leu Asn Asp Pro Thr Ser Tyr 
             260                265                270
Tyr Ile Gln Ile Phe Val Val Asp Ile Tyr Ala Thr Val Ser Pro Phe 
         275                280                285
Val Phe Met Ser Thr Gly Lys His Ile Val Asn Phe Leu Lys Ser Met 
     290                295                300
Cys Val Arg Val Lys Asn Val Ter 
 305                310



<210> 8501
<211> 1062
<212> DNA
<213> Homo sapiens
<308> AF255342
<400> 8501

atggttgga  acacattaa  acttctgtc  ccactgatg  caagatact  ctttctgct  60
ttttattct  ctgattctt  agacctcaa  gaaaatcaa  atcccctag  ttttgatga  120
atggctttt  gaaaagtaa  atcagggat  agcttcctc  ttcagactg  agttgggat  180
ctgggaaat  cctttctcc  ttgttttta  aacttaatt  tgttcactg  acacaagct  240
agacccacg  acttgattc  cagccaact  gccttggct  actccatgg  ccttttctt  300
aaagggata  ctcagacaa  ggcagcttt  ggattgaaa  atttgctga  tgacactgg  360
tgtaagttt  tcttttatt  tcacagggt  ggcacaaga  tttccctca  caccatctg  420
cttctcaat  gattccaag  cattaagct  aaccccagt  tatgcaggt  gatggagat  480
aagattaga  ccccaaggt  tattgactt  tgttgtctc  tctgctggg  cccccatgt  540
ttgatgaat  catctgttc  tctattagt  aatggccca  tgaatagca  aaacagtag  600
gcaaaaaac  attatggat  ctgttctta  aaagcatca  agagattta  ctcattaca  660
gcagtctta  atttttccc  tgattttat  agtttgggc  tcatggtct  ggccagtgg  720
tccatggtc  tcttcctct  cagacacaa  cagcaagtc  aacacaatc  cagcaacag  780
ctctcctgc  gaccttccc  ggaagccag  gccacacac  ccatcatgg  cctggtgag  840
tcctttttt  ttttctatt  agtccatag  tttctgaca  tttggacaa  tgtagttgc  900
aacccaggc  agtggatag  gaccaactc  gtgttggtc  cctcatgtt  cccagcacg  960
agccctttt  tcctcatca  gagtgatac  catatctct  agttctgtt  tgcctgcag  1020
acaaggaaa  cactctttc  taatctggt  gtcatgcca  ga  1062



<210> 8502
<211> 353
<212> PRT
<213> Homo sapiens
<308> AAG10698
<400> 8502

Met Val Gly Asp Thr Leu Lys Leu Leu Ser Pro Leu Met Thr Arg Tyr 
  1               5                  10                  15
Phe Phe Leu Leu Phe Tyr Ser Thr Asp Ser Ser Asp Leu Asn Glu Asn 
             20                  25                  30
Gln His Pro Leu Asp Phe Asp Glu Met Ala Phe Gly Lys Val Lys Ser 
         35                  40                  45
Gly Ile Ser Phe Leu Ile Gln Thr Gly Val Gly Ile Leu Gly Asn Ser 
     50                  55                  60
Phe Leu Leu Cys Phe Tyr Asn Leu Ile Leu Phe Thr Gly His Lys Leu 
 65                  70                  75                  80
Arg Pro Thr Asp Leu Ile Leu Ser Gln Leu Ala Leu Ala Asn Ser Met 
                 85                  90                  95
Val Leu Phe Phe Lys Gly Ile Pro Gln Thr Met Ala Ala Phe Gly Leu 
             100                105                110
Lys Tyr Leu Leu Asn Asp Thr Gly Cys Lys Phe Val Phe Tyr Tyr His 
         115                120                125
Arg Val Gly Thr Arg Val Ser Leu Ser Thr Ile Cys Leu Leu Asn Gly 
     130                135                140
Phe Gln Ala Ile Lys Leu Asn Pro Ser Ile Cys Arg Trp Met Glu Ile 
 145                150                155                160
Lys Ile Arg Ser Pro Arg Phe Ile Asp Phe Cys Cys Leu Leu Cys Trp 
                 165                170                175
Ala Pro His Val Leu Met Asn Ala Ser Val Leu Leu Leu Val Asn Gly 
             180                185                190
Pro Leu Asn Ser Lys Asn Ser Ser Ala Lys Asn Asn Tyr Gly Tyr Cys 
         195                200                205
Ser Tyr Lys Ala Ser Lys Arg Phe Ser Ser Leu His Ala Val Leu Tyr 
     210                215                220
Phe Ser Pro Asp Phe Met Ser Leu Gly Phe Met Val Trp Ala Ser Gly 
 225                230                235                240
Ser Met Val Phe Phe Leu Tyr Arg His Lys Gln Gln Val Gln His Asn 
                 245                250                255
His Ser Asn Arg Leu Ser Cys Arg Pro Ser Gln Glu Ala Arg Ala Thr 
             260                265                270
His Thr Ile Met Val Leu Val Ser Ser Phe Phe Val Phe Tyr Ser Val 
         275                280                285
His Ser Phe Leu Thr Ile Trp Thr Thr Val Val Ala Asn Pro Gly Gln 
     290                295                300
Trp Ile Val Thr Asn Ser Val Leu Val Ala Ser Cys Phe Pro Ala Arg 
 305                310                315                320
Ser Pro Phe Val Leu Ile Met Ser Asp Thr His Ile Ser Gln Phe Cys 
                 325                330                335
Phe Ala Cys Arg Thr Arg Lys Thr Leu Phe Pro Asn Leu Val Val Met 
             340                345                350
Pro 
         355



<210> 8503
<211> 585
<212> DNA
<213> Rattus norvegicus
<308> U37099
<400> 8503

gaccagaat  ttgattaca  gttcaagtt  ctgatcatt  gcaatagca  cgtgggcaa  60
acatccttc  tgttccgct  tgctgatga  tccttcacg  ccgcctttg  cagcacggt  120
ggcatcgat  tcaaagtaa  aactgtctt  aaaaatgaa  agagaatca  gcttcagat  180
tgggacaca  caggccagg  aagatacag  accatcacc  cagcctatt  tcgaggggc  240
atgggcttc  ttttaatgt  tgacatcac  aatgaagaa  ccttcaacg  tgtacaaga  300
tggtcaact  agatcaaaa  atattcctg  gataatgcc  aggttatcc  ggccggaaa  360
aaatgtgac  tggaagacg  acgggtggt  tcaactgag  gagggcagc  cttaggaga  420
cagctcggg  ttgagtttt  tgaaaccag  gccaaggat  acatcaacg  caagcaaac  480
tttgagcgc  tcgtagata  catctgtga  aaaatgtca  agagcttgg  gactgaccc  540
gccatcaca  ccgccaagc  gagcacaag  ctcaaggaa  cgcct  585



<210> 8504
<211> 219
<212> PRT
<213> Rattus norvegicus
<308> AAC52704
<400> 8504

Met Ala Ser Ala Gln Asp Ala Arg Phe Gly Gln Lys Asp Ser Ser Asp 
  1               5                  10                  15
Gln Asn Phe Asp Tyr Met Phe Lys Leu Leu Ile Ile Gly Asn Ser Ser 
             20                  25                  30
Val Gly Lys Thr Ser Phe Leu Phe Arg Tyr Ala Asp Asp Ser Phe Thr 
         35                  40                  45
Ser Ala Phe Val Ser Thr Val Gly Ile Asp Phe Lys Val Lys Thr Val 
     50                  55                  60
Phe Lys Asn Glu Lys Arg Ile Lys Leu Gln Ile Trp Asp Thr Ala Gly 
 65                  70                  75                  80
Gln Glu Arg Tyr Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly Ala Met 
                 85                  90                  95
Gly Phe Ile Leu Met Tyr Asp Ile Thr Asn Glu Glu Ser Phe Asn Ala 
             100                105                110
Val Gln Asp Trp Ser Thr Gln Ile Lys Thr Tyr Ser Trp Asp Asn Ala 
         115                120                125
Gln Val Ile Leu Ala Gly Asn Lys Cys Asp Met Glu Asp Glu Arg Val 
     130                135                140
Val Ser Thr Glu Arg Gly Gln Arg Leu Gly Glu Gln Leu Gly Phe Glu 
 145                150                155                160
Phe Phe Glu Thr Ser Ala Lys Asp Asn Ile Asn Val Lys Gln Thr Phe 
                 165                170                175
Glu Arg Leu Val Asp Ile Ile Cys Asp Lys Met Ser Glu Ser Leu Glu 
             180                185                190
Thr Asp Pro Ala Ile Thr Ala Ala Lys Gln Ser Thr Arg Leu Lys Glu 
         195                200                205
Thr Pro Pro Pro Pro Gln Pro Asn Cys Gly Cys 
     210                215



<210> 8506
<211> 220
<212> PRT
<213> Homo sapiens
<308> P20336
<400> 8506

Met Ala Ser Ala Thr Asp Ser Arg Tyr Gly Gln Lys Glu Ser Ser Asp 
  1               5                  10                  15
Gln Asn Phe Asp Tyr Met Phe Lys Ile Leu Ile Ile Gly Asn Ser Ser 
             20                  25                  30
Val Gly Lys Thr Ser Phe Leu Phe Arg Tyr Ala Asp Asp Ser Phe Thr 
         35                  40                  45
Pro Ala Phe Val Ser Thr Val Gly Ile Asp Phe Lys Val Lys Thr Ile 
     50                  55                  60
Tyr Arg Asn Asp Lys Arg Ile Lys Leu Gln Ile Trp Asp Thr Ala Gly 
 65                  70                  75                  80
Gln Glu Arg Tyr Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly Ala Met 
                 85                  90                  95
Gly Phe Ile Leu Met Tyr Asp Ile Thr Asn Glu Glu Ser Phe Asn Ala 
             100                105                110
Val Gln Asp Trp Ser Thr Gln Ile Lys Thr Tyr Ser Trp Asp Asn Ala 
         115                120                125
Gln Val Leu Leu Val Gly Asn Lys Cys Asp Met Glu Asp Glu Arg Val 
     130                135                140
Val Ser Ser Glu Arg Gly Arg Gln Leu Ala Asp His Leu Gly Phe Glu 
 145                150                155                160
Phe Phe Glu Ala Ser Ala Lys Asp Asn Ile Asn Val Lys Gln Thr Phe 
                 165                170                175
Glu Arg Leu Val Asp Val Ile Cys Glu Lys Met Ser Glu Ser Leu Asp 
             180                185                190
Thr Ala Asp Pro Ala Val Thr Gly Ala Lys Gln Gly Pro Gln Leu Ser 
         195                200                205
Asp Gln Gln Val Pro Pro His Gln Asp Cys Ala Cys 
     210                215                220



<210> 8507
<211> 2472
<212> DNA
<213> Rattus norvegicus
<308> U37138
<400> 8507

ggcaacacc  cgacctctg  acccgtgcc  cagagacaa  accgcgacc  tctggcgac  60
tctgaccct  tgaccctgt  tggtgtgac  tcacgaccc  ggcgccctc  gcggtgacc  120
ttgaccccg  agcgacccc  agaccccag  acccctgca  ttatccaca  ctctgggac  180
tccaacccc  cgaccccaa  agcgacctc  gaccctggt  aaagcagga  aacccggga  240
accagtgac  ctgcaactt  tgaccccac  aagggcaac  actctgaga  tgtacggtg  300
cctctgacc  ctgaccctg  gctgttccc  cgagataac  gtgacccca  gaactccaa  360
tcagctaca  cctggtgac  accaaggta  cccagggac  acctctgac  ccttgaatc  420
acgactttt  acccagtgc  gaccactgc  gtgtggggc  gtctgagag  gtgcgtgac  480
tttgatctc  gacctctga  cccgaccca  ccttgccca  aggacgatg  tctggccct  540
tctccttgc  ctgctcctc  cccagctca  ctttctctg  gctgcccgt  ctggccctg  600
acctaactt  ctgctcatc  tggctgatg  ccttggcat  ggggaccta  gctgctatg  660
caaccgcac  ctcaggacg  cacacatcg  ccgcctggc  cttgagggg  tgaagttga  720
tcagcacct  gcggctgcg  ccctgtgca  cccgagccg  gctgccttc  ttaccgggc  780
ctaccctgt  cggtcaggg  tggcatcac  tggccgcct  ggtgtattc  tgttctcgg  840
atcatctgg  gggctcccg  ccaatgaag  cacctttgc  aagttgctc  agggtcaag  900
ctacaccac  gggcttgta  ggaagtggc  tctggggct  agctgccaa  cagcctctg  960
cttctgcca  caccctggg  gccatggct  tgaccgctt  ctgggcacg  ccaccacca  1020
cctgaggga  tgcaagcca  ggggcggga  cgtgtttgg  tctgcccaa  aagtattcg  1080
ggtcctgcc  atgaatatt  tgggggcag  gctgctggc  atggcactt  cgcggtggg  1140
agggctggc  cggccccca  ggtgggtgt  cggggtgac  gtggctgcc  tggcggcgg  1200
gggcggggc  tatgtggcc  tcctctacc  cttccgccc  gccaactgc  tcctcatgg  1260
cgacttcac  atcacccaa  agcccacgg  ctacaaggg  ctcacacag  gcctggcaa  1320
cgaggctgg  gacttcctg  gcaggaaca  ggacacgcc  ttcctgcta  tcctgtctt  1380
catgcatgt  cacacggca  acttcgcca  ccctgagtt  gccgggcag  gcctgcatg  1440
ggcctatgg  gatgctgtg  aggagatgg  ctgggccgt  ggccaggtc  ttgccacac  1500
ggacaagct  ggcctcgcc  acaacacac  cgtgtactt  acgtccgac  atggcgcac  1560
cgtggagga  cttggcccc  acggtgaac  gcatggcgg  agcaacgga  tttacaggg  1620
cgggaaggc  aacacgtgg  agggtggca  ccgtgtgcc  ggacttgtg  gctggcccg  1680
cgtgattgt  cccggccag  aggtcgagg  gcccacgag  aacatggac  tcttcccca  1740
tgtggccag  cttgcaggg  cagagctgc  gactgacag  gtgattgac  ggcgtgact  1800
gatgcccct  ctgctgggc  atgtacaac  ctctgagca  gaattcctg  tccactact  1860
caatgccta  ctcagcgct  tggcatggc  gccccacaa  agctcgtcc  tgtggaagg  1920
gttttactt  acaccgaac  tcgaccccc  gggctctaa  ggctgcttc  ccacacacg  1980
gtgcatgtg  cacggccac  atgtcacgc  ccatgatcc  cccctgctc  tcgacattg  2040
ccgtgaccc  agggagcgc  acccgctca  gcctgaaac  gagccgcgc  atggtgaga  2100
cctgcgcaa  atggatgct  cggcccgtg  acacgttgc  accctagag  aggcgccca  2160
tcagctttc  atgtcaaat  tcgcatgga  gccatggct  cagctctgc  tgccttcca  2220
gccccaccc  ctcgcatgc  gctgtgctg  cgacgggtg  gttgggcat  ccaaacaca  2280
aggtatgca  gcatgggac  ctgtggcct  gtgatttca  ctcctgaac  gatacctga  2340
acaatcttg  tgacatgta  gaaaacata  gaacatgta  gaacatgtg  atgctgagt  2400
caaaacaca  gaagagccc  tcagcatga  cctgatgaa  aaatgatgt  gacacggaa  2460
aaaaaaaaa  aa  2472



<210> 8508
<211> 577
<212> PRT
<213> Rattus norvegicus
<308> P15589
<400> 8508

Met Leu Trp Pro Cys Leu Leu Ala Leu Leu Leu Ser Gln Leu Asn Phe 
  1               5                  10                  15
Leu Cys Ala Ala Arg Pro Gly Pro Gly Pro Asn Phe Leu Leu Ile Met 
             20                  25                  30
Ala Asp Asp Leu Gly Ile Gly Asp Leu Gly Cys Tyr Gly Asn Arg Thr 
         35                  40                  45
Leu Arg Thr Pro His Ile Asp Arg Leu Ala Leu Glu Gly Val Lys Leu 
     50                  55                  60
Thr Gln His Leu Ala Ala Ala Pro Leu Cys Thr Pro Ser Arg Ala Ala 
 65                  70                  75                  80
Phe Leu Thr Gly Arg Tyr Pro Val Arg Ser Gly Met Ala Ser His Gly 
                 85                  90                  95
Arg Leu Gly Val Phe Leu Phe Ser Ala Ser Ser Gly Gly Leu Pro Pro 
             100                105                110
Asn Glu Val Thr Phe Ala Lys Leu Leu Lys Gly Gln Gly Tyr Thr Thr 
         115                120                125
Gly Leu Val Gly Lys Trp His Leu Gly Leu Ser Cys Gln Ala Ala Ser 
     130                135                140
Asp Phe Cys His His Pro Gly Arg His Gly Phe Asp Arg Phe Leu Gly 
 145                150                155                160
Thr Pro Thr Thr Asn Leu Arg Asp Cys Lys Pro Gly Gly Gly Thr Val 
                 165                170                175
Phe Gly Ser Ala Gln Gln Val Phe Val Val Leu Pro Met Asn Ile Leu 
             180                185                190
Gly Ala Val Leu Leu Ala Met Ala Leu Ala Arg Trp Ala Gly Leu Ala 
         195                200                205
Arg Pro Pro Gly Trp Val Phe Gly Val Thr Val Ala Ala Met Ala Ala 
     210                215                220
Val Gly Gly Ala Tyr Val Ala Phe Leu Tyr His Phe Arg Pro Ala Asn 
 225                230                235                240
Cys Phe Leu Met Ala Asp Phe Thr Ile Thr Gln Gln Pro Thr Asp Tyr 
                 245                250                255
Lys Gly Leu Thr Gln Arg Leu Ala Ser Glu Ala Gly Asp Phe Leu Arg 
             260                265                270
Arg Asn Arg Asp Thr Pro Phe Leu Leu Phe Leu Ser Phe Met His Val 
         275                280                285
His Thr Ala His Phe Ala Asn Pro Glu Phe Ala Gly Gln Ser Leu His 
     290                295                300
Gly Ala Tyr Gly Asp Ala Val Glu Glu Met Asp Trp Ala Val Gly Gln 
 305                310                315                320
Val Leu Ala Thr Leu Asp Lys Leu Gly Leu Ala Asn Asn Thr Leu Val 
                 325                330                335
Tyr Leu Thr Ser Asp His Gly Ala His Val Glu Glu Leu Gly Pro Asn 
             340                345                350
Gly Glu Arg His Gly Gly Ser Asn Gly Ile Tyr Arg Gly Gly Lys Ala 
         355                360                365
Asn Thr Trp Glu Gly Gly Ile Arg Val Pro Gly Leu Val Arg Trp Pro 
     370                375                380
Gly Val Ile Val Pro Gly Gln Glu Val Glu Glu Pro Thr Ser Asn Met 
 385                390                395                400
Asp Val Phe Pro Thr Val Ala Arg Leu Ala Gly Ala Glu Leu Pro Thr 
                 405                410                415
Asp Arg Val Ile Asp Gly Arg Asp Leu Met Pro Leu Leu Leu Gly His 
             420                425                430
Val Gln His Ser Glu His Glu Phe Leu Phe His Tyr Cys Asn Ala Tyr 
         435                440                445
Leu Ser Ala Val Ala Trp Arg Pro His Asn Ser Ser Ser Val Trp Lys 
     450                455                460
Ala Phe Tyr Phe Thr Pro Asn Phe Asp Pro Pro Gly Ser Asn Gly Cys 
 465                470                475                480
Phe Ser Thr His Val Cys Met Cys His Gly His His Val Thr His His 
                 485                490                495
Asp Pro Pro Leu Leu Phe Asp Ile Ala Arg Asp Pro Arg Glu Arg His 
             500                505                510
Pro Leu Thr Pro Glu Thr Glu Pro Arg His Gly Glu Ile Leu Arg Asn 
         515                520                525
Met Asp Ala Ala Ala Arg Ala His Val Ala Thr Leu Glu Glu Ala Pro 
     530                535                540
Asn Gln Leu Ser Met Ser Asn Val Ala Trp Lys Pro Trp Leu Gln Leu 
 545                550                555                560
Cys Leu Pro Ser Lys Pro His Pro Leu Ala Cys Arg Cys Ala Gly Asp 
                 565                570                575
Gly 
             580



<210> 8509
<211> 6520
<212> DNA
<213> Homo sapiens
<308> M16505
<400> 8509

acagtgctg  tggccaagc  tccagcagc  gacgggacc  agctgtagt  aggttgcag  60
gattgagta  gattggcct  cttcaaagc  gaggtttct  atgggaata  gcttattaa  120
ctcccactg  tgcagaaac  atgaacaga  gatgaacaa  tgaagttgc  atctcctcc  180
tcacagctc  gttccccaa  aacaggatc  caagctgga  atgccttta  ggaagatga  240
gatcccttt  ctcctactg  tctttctgt  ggaagccga  agccacgaa  catcaaggc  300
gaacatcat  ctggtgatg  ctgacgacc  cggcattgg  gatcctggg  gctatggga  360
caaaactat  aggactccc  atatcgacc  gttggccag  gggggagtg  aactcactc  420
gcacctggc  gcatcaccg  tgtgcacac  aagcagggc  gccttcatg  ctggccggt  480
ccctgtccg  tcaggaatg  catcttggt  ccgcactgg  gttttcctc  tcacagcct  540
ttcgggagg  cttcccacc  atgagatta  ctttgctaa  cttctgaag  atcaaggtt  600
ttcaacagc  ctgataggg  aatggcacc  tgggatgag  tgtcacagc  agactgact  660
ctgtcacca  cctttacat  acggcttca  ttatttcta  gggatctct  tgaccaatc  720
gagagactg  aagcccgga  agggcagtg  cttcaccac  ggcttcaag  ggctggtct  780
cctccccct  cagatcgtc  gggtcaccc  ccttaccct  gctgcactc  attgtctgg  840
gctactcca  gtgcctcta  gcgtttttt  cagccttct  ttcctagca  ccctaatcc  900
gaccctttt  ttgggcttc  ttcattact  ccggcccct  aactgcttc  tgatgagga  960
ctacgagat  attcagcag  ccatgtcct  tgacaatct  acccagagg  taacggtgg  1020
ggcggccca  ttcatacag  ggaacactg  gactccgtt  ctgcttgtc  tgtcctacc  1080
ccacgtgca  acagccctg  tctccagca  agactttgc  ggcaaaagt  aacacggag  1140
ctacgggga  gctgttgag  aaatggact  gagtgtggg  cagatcttg  accttctgg  1200
tgagctgag  ttggctaat  ataccctca  ctacttcac  tcggaccag  gagcacatg  1260
agaagaagt  tcttccaaa  gagaaattc  tggcggaag  aatgggatc  ataaaggag  1320
aaaagcaaa  aactgggaa  gaggtatcc  ggttccagg  atccttcgt  ggcccaggg  1380
gatacaggc  ggccagaag  ttgatgagc  cactagcaa  atggacata  ttcctacag  1440
agccaagct  gctggagct  ccttgcctg  ggacaggat  attgatgga  gtgatctga  1500
gcccctgct  gaaggaaaa  gccaacgct  cgatcatga  tttctcttc  attactgca  1560
cgcctactt  aatgctgtg  gctggcacc  tcagaacag  acatccatc  ggaaggcct  1620
tttcttcac  cccaacttc  accccgtgg  ttccaacgg  tgctttgcc  cacacgtgt  1680
cttctgttt  gggagttat  tcacccatc  cgacccacc  ttactcttt  atatttcca  1740
agatcccag  gagagaaac  cacttactc  agcatccga  ccccggttt  atgaaatcc  1800
caaagtcat  caggaagct  cggacagac  cacccagac  ctgccagag  tgcccgatc  1860
gttttcatg  aacaacttt  tttggaagc  ctggcttca  ctgtgctgt  cttccaccg  1920
cctgtcttg  cagtgtgat  gagaaaaac  ggataagag  ctgagccgc  agcagcgcc  1980
ggggaccag  cagacgcat  tggcaaagc  caccatctt  actacaaac  cgcctgaga  2040
tggcactgg  gaaacataa  tccatctac  ccttggatt  ggactgatt  tccatttta  2100
cacctgaag  cttgggcca  agctcaaca  ctactcaac  ggaggggtg  gggggataa  2160
gtctgtagt  tacagacag  aagatggta  gtttatgcc  tctgtggcc  gagtcttgg  2220
ctcatggaa  tagaatgaa  agaggggca  tcacaaggc  caccagtgc  agcagatga  2280
aaaaaggtg  agaaggcaa  cttaaaaca  aaaggtgca  gaggtacct  aactcaccc  2340
tcagcaaat  cctatgtca  cagtataag  taccattta  tctataatc  gcagtgatg  2400
aataaccag  ataataaaa  ggcaatcac  taaaaaaga  tttagtcgt  taaacataa  2460
taactttaa  gtgaatgaa  gatcttctt  aggaataat  gatgatggt  agttccact  2520
tggttattg  aaggcaagt  attattatt  gtattagtt  aaacacata  caaatgctt  2580
ctcttcatc  tatatatag  tatgcatac  tacacacac  cacatacag  atattcttt  2640
ctcaaaagg  ttaagatgt  taaaatagg  acctagaag  ttaacacta  ttaagtaaa  2700
acagtagaa  ctcacaaat  gatttcttt  cacaatgat  ttttgcaaa  ttttacagt  2760
ataataatc  caaggcaaa  ctctcctga  ctgctttcc  ttccataat  tgtagtata  2820
ttcttggat  ccactgttt  ctttgggga  tggaagttc  gaattaaaa  cccactgtg  2880
agatgctgt  gttcatgga  tctcttcca  tgtaattca  aatcatggc  tagaaagtc  2940
ctgatattt  gaggggaac  aaaatcact  acaagcaat  catgatcta  acacataag  3000
ataatttcc  ttagttcta  ttagtcatc  gagaacagt  atgtatgca  gttttgtga  3060
tgagaaatt  ctgtgcttc  aatccacaa  gagatgcat  attttgttt  catcccatt  3120
cccccaagc  cctgtaaat  agggaaaat  cgcaactga  cgcctagga  agggcctcg  3180
agtggcaca  ctggagata  tttcaaagt  taaaccacc  gcccatcct  aggaaagcc  3240
cctatggaa  gtaaagtgc  atcatttct  cagatataa  actttcccc  acaatgtga  3300
tggattcct  tatgctcaa  atcgagaga  gctgccatc  acctgctta  gcatttatc  3360
cttttgtgg  cttgtctga  caccttcta  ttgcccaga  tttgctcaa  tccaagaca  3420
tgcccatga  tgggacacc  gtaatgtaa  ccacacagc  gtttgcaga  aatgttagc  3480
atgacttgg  ctttgtaaa  ttggctata  tttctctat  cctacccac  accctggga  3540
gttggagca  gaggggcat  ctattgggc  gggaggatt  gacagcatt  ccccagttg  3600
cctttaagt  cttctattt  aaacgttaa  tttgcttct  tttctaaaa  aaaaaaaaa  3660
aaagaaaga  aagaaagaa  tgattccta  ccctacctc  agagttgtt  aaagctgaa  3720
agcatacaa  attcttcct  ttaacttgg  tttctcgtt  cagaaattg  gggataatc  3780
gtattcttg  tttagaaaa  aattcttag  gagggtact  gcttactga  gatgtgtta  3840
gattgctac  gatgctgtc  tgtggaaac  atttaaagg  actattata  atttatcct  3900
taagatgac  atgtttact  aaagtctaa  atattcaat  caagtaaga  tttctgaaa  3960
cacttgatg  tgtggaaat  ctgcaggac  taaataact  gaagagcct  tatagatta  4020
atgaatgcc  atttgtgtc  agaaccagt  atttaacct  taaaatgtc  atagcaaat  4080
aaggatgaa  tatatctct  gatgcaaat  cattgagtt  aaaagtgcc  caaaataat  4140
gagatcaca  ttcaggaca  ttggaaatc  ggtcgattt  tggtaactg  agtcatctt  4200
aatttcaaa  catttacca  ctgaaagtt  tgatttgaa  gtaaaacag  aaattggaa  4260
tcctttgtc  aggagaaac  tcacaaacc  tctttaagg  atagttttg  tgtttgttt  4320
cttgtttgt  gcaggctgt  aggcatggc  gcttgttta  aaagcatct  attcatatt  4380
cctgtggag  tgcatatcc  aaccttagt  agttttgaa  ctttaagca  attctttta  4440
aaaattctt  tatttctag  attactaga  attaaaagt  aagcaaata  attaatgac  4500
tatacatag  catcatttc  caaggtcag  aatgctgca  gaaaagcaa  attgcaatc  4560
acgtatcta  ggtactaag  aagtcctgt  ttcaaaaat  gaagcccac  tctcagatt  4620
ttctgaagg  catacaatg  aaagtgaag  ggaaacaca  acacacaaa  aaaacaagt  4680
tttggcttg  cacaggaat  tgattgcat  aagtgaagg  ttatttaga  tatgttaat  4740
caaagctaa  ataaaattt  ccttggcaa  taaaaatgc  gtgcgctaa  accctgctt  4800
ctatcgtga  tcaattcaa  aatgtgggg  atgtttact  catttccaa  ttgatgtca  4860
gcaatgggg  atacaagtt  cagttctgc  aagattcgt  aactttctt  gctcaagag  4920
gaggctgag  aatgcagag  agaataaga  ataaaatag  tccgacctc  atgatccga  4980
agtgggaaa  ggcccgatt  ttacccata  ggcacactc  ctaaggcct  ttaaggggc  5040
tacaaaaat  ttttatttt  taatcagaa  aaaaggaaa  gaacattgg  gattgaaaa  5100
catattggt  tttgcacca  catagtcat  aaatagtat  ttaatatgt  tttacttta  5160
atatttata  attaaaata  atttaatat  ttttgcctt  gtggcccat  aaagtctta  5220
tgggccctg  ggaaggtat  ctaccctgg  gaagcagct  ctttgctct  caaatacct  5280
gggcagaaa  ttgatttga  aagtattat  ctctcttct  tttgtttca  ctggattcc  5340
ttggaaaac  aaactagta  cagaacaaa  cccgaaaca  taagaaatt  gagtgagaa  5400
ggcatggta  tgggactag  atcggctct  attcgatcg  gctattctc  taaaatgac  5460
aaaagtgtc  ataaagagg  tgctggaga  tgcgtggcc  tagggagcc  acatgcccg  5520
gaggaaagg  gttgattac  tggatactt  taaaagcta  agccttgtt  ccttctctt  5580
aatgcctag  gaatgggat  tgtgatgca  atgctcaaa  cctcttaaa  catagctgt  5640
tgacctcta  ggacctcac  tccatctga  gcttcatgg  caaagattc  ccacttggc  5700
aaactttag  caagctcct  aaccttctc  caggcccaa  ctgggcact  ccttgtaaa  5760
tctagtttt  gcaagaagt  tattaggtc  gtttagcaa  aacacctaa  ccccccata  5820
ctgttcaac  tcagtatct  atcaggctc  tcagcctcc  ccatccccc  ggtgatgtc  5880
ggtcaactg  cctaccttc  gctagaatc  tgttaggtc  gtttagatg  atgctccct  5940
atatttcct  ttggtaatc  tccatccac  gcccatgac  ctgttccct  tctataaat  6000
cccagtttt  catggtata  tcagagctg  gtccagtct  tctccccta  tacaagtcc  6060
cattgctgt  gtccccgta  ctgtcatga  ggtcctaaa  aaagtctta  tgtgcttta  6120
taggtagca  tgaaaaatt  ttttctttg  catcattca  gacaacatg  aacctattg  6180
gacagcatg  ctgtgcagg  tctttagag  tcagctttc  gaggccctg  gcattcttg  6240
ttttccgac  tcgtgaacc  gttctgtgt  gcaagatat  actcaagcc  gtgttgctt  6300
ataccatct  tttgtgtaa  agatctgaa  aaagtaatt  taatacacc  atattttac  6360
ttgttgagt  ttattttaa  gggagcctt  ccaatgaag  aaacatcag  tttccttgt  6420
agaatgcaa  cagcttaaa  actacccat  tctttctgg  aaggaaaca  tgccatgta  6480
ctatgtatc  gttttctaa  aacttcatg  gccttccata  6520



<210> 8510
<211> 583
<212> PRT
<213> Homo sapiens
<308> P08842
<400> 8510

Met Pro Leu Arg Lys Met Lys Ile Pro Phe Leu Leu Leu Phe Phe Leu 
  1               5                  10                  15
Trp Glu Ala Glu Ser His Ala Ala Ser Arg Pro Asn Ile Ile Leu Val 
             20                  25                  30
Met Ala Asp Asp Leu Gly Ile Gly Asp Pro Gly Cys Tyr Gly Asn Lys 
         35                  40                  45
Thr Ile Arg Thr Pro Asn Ile Asp Arg Leu Ala Ser Gly Gly Val Lys 
     50                  55                  60
Leu Thr Gln His Leu Ala Ala Ser Pro Leu Cys Thr Pro Ser Arg Ala 
 65                  70                  75                  80
Ala Phe Met Thr Gly Arg Tyr Pro Val Arg Ser Gly Met Ala Ser Trp 
                 85                  90                  95
Ser Arg Thr Gly Val Phe Leu Phe Thr Ala Ser Ser Gly Gly Leu Pro 
             100                105                110
Thr Asp Glu Ile Thr Phe Ala Lys Leu Leu Lys Asp Gln Gly Tyr Ser 
         115                120                125
Thr Ala Leu Ile Gly Lys Trp His Leu Gly Met Ser Cys His Ser Lys 
     130                135                140
Thr Asp Phe Cys His His Pro Leu His His Gly Phe Asn Tyr Phe Tyr 
 145                150                155                160
Gly Ile Ser Leu Thr Asn Leu Arg Asp Cys Lys Pro Gly Glu Gly Ser 
                 165                170                175
Val Phe Thr Thr Gly Phe Lys Arg Leu Val Phe Leu Pro Leu Gln Ile 
             180                185                190
Val Gly Val Thr Leu Leu Thr Leu Ala Ala Leu Asn Cys Leu Gly Leu 
         195                200                205
Leu His Val Pro Leu Gly Val Phe Phe Ser Leu Leu Phe Leu Ala Ala 
     210                215                220
Leu Ile Leu Thr Leu Phe Leu Gly Phe Leu His Tyr Phe Arg Pro Leu 
 225                230                235                240
Asn Cys Phe Met Met Arg Asn Tyr Glu Ile Ile Gln Gln Pro Met Ser 
                 245                250                255
Tyr Asp Asn Leu Thr Gln Arg Leu Thr Val Glu Ala Ala Gln Phe Ile 
             260                265                270
Gln Arg Asn Thr Glu Thr Pro Phe Leu Leu Val Leu Ser Tyr Leu His 
         275                280                285
Val His Thr Ala Leu Phe Ser Ser Lys Asp Phe Ala Gly Lys Ser Gln 
     290                295                300
His Gly Val Tyr Gly Asp Ala Val Glu Glu Met Asp Trp Ser Val Gly 
 305                310                315                320
Gln Ile Leu Asn Leu Leu Asp Glu Leu Arg Leu Ala Asn Asp Thr Leu 
                 325                330                335
Ile Tyr Phe Thr Ser Asp Gln Gly Ala His Val Glu Glu Val Ser Ser 
             340                345                350
Lys Gly Glu Ile His Gly Gly Ser Asn Gly Ile Tyr Lys Gly Gly Lys 
         355                360                365
Ala Asn Asn Trp Glu Gly Gly Ile Arg Val Pro Gly Ile Leu Arg Trp 
     370                375                380
Pro Arg Val Ile Gln Ala Gly Gln Lys Ile Asp Glu Pro Thr Ser Asn 
 385                390                395                400
Met Asp Ile Phe Pro Thr Val Ala Lys Leu Ala Gly Ala Pro Leu Pro 
                 405                410                415
Glu Asp Arg Ile Ile Asp Gly Arg Asp Leu Met Pro Leu Leu Glu Gly 
             420                425                430
Lys Ser Gln Arg Ser Asp His Glu Phe Leu Phe His Tyr Cys Asn Ala 
         435                440                445
Tyr Leu Asn Ala Val Arg Trp His Pro Gln Asn Ser Thr Ser Ile Trp 
     450                455                460
Lys Ala Phe Phe Phe Thr Pro Asn Phe Asn Pro Val Gly Ser Asn Gly 
 465                470                475                480
Cys Phe Ala Thr His Val Cys Phe Cys Phe Gly Ser Tyr Val Thr His 
                 485                490                495
His Asp Pro Pro Leu Leu Phe Asp Ile Ser Lys Asp Pro Arg Glu Arg 
             500                505                510
Asn Pro Leu Thr Pro Ala Ser Glu Pro Arg Phe Tyr Glu Ile Leu Lys 
         515                520                525
Val Met Gln Glu Ala Ala Asp Arg His Thr Gln Thr Leu Pro Glu Val 
     530                535                540
Pro Asp Gln Phe Ser Trp Asn Asn Phe Leu Trp Lys Pro Trp Leu Gln 
 545                550                555                560
Leu Cys Cys Pro Ser Thr Gly Leu Ser Cys Gln Cys Asp Arg Glu Lys 
                 565                570                575
Gln Asp Lys Arg Leu Ser Arg 
             580



<210> 8511
<211> 3077
<212> DNA
<213> Rattus norvegicus
<308> U37142
<400> 8511

ggcacgagg  gggacgcgg  gtgtggagg  gacctcaca  gttcttcca  gtttgcagc  60
tgatcccat  gcttctgtc  ctgctggca  ctctggtcc  gacccaagc  cctgcagcc  120
tcgctgatg  cctgaaaga  gacagctca  aggatcgag  ctttcgggt  cgcatcggt  180
ccgcgcagc  gcggggtgt  ctgggcggt  ccctggcca  cccatgcca  gtccaccac  240
tgaggccgc  gcccagccg  cgggccgcg  cgggctttc  ccgagtcaa  tggaccttc  300
tgtccgggg  ccgggaggt  gaggtgctg  tggcgcgcg  gctgcgcgt  aaggtaaac  360
aagcctatc  gttccgcgt  gcgctgcct  cctaccccg  atcgctcac  gatgtgtct  420
tagtattga  cgaactgcg  cccaatgat  ccggggtct  tcgctgcga  gtccagcac  480
gtatcgacg  cagcagtga  gctgtggaa  tcaaggtca  aggggtcgt  ttcctctac  540
gagagggct  tgcccgcta  gctttctcc  tcgctggag  ccaggaagc  tgtgctcgc  600
tcggagccc  aattgccac  cctgagcag  tgtatgctg  ctacctcgg  ggctatgaa  660
agtgtgatg  tggctggct  tccgaccaa  ccgtgaggt  ccccatcca  aacccacga  720
aagcctgtt  tggagacat  gatggctac  ctggagtgc  gaattacgg  gtggtgggt  780
ctgatgatc  ctacgatgt  tactgttat  ccgaagacc  aaatggaga  ctgttccta  840
gtgcccctc  cggcaagct  acgtgggag  aggctcggg  ctactgtct  gaacgcggt  900
ctcagatcg  tagcacggg  cagctatac  cggcatgga  tggcggctt  gacagatgt  960
gccctggct  gctggctga  ggcagtgtg  ggtacccca  catcacgcc  agccaacgc  1020
gtgggggag  cctgccagg  gtcaagacc  tcttcctct  tcccaacca  actggcttc  1080
ccagcaagc  gaaccgctt  aatgtctac  gcttccgag  ctctgccca  ccctctgcc  1140
tctctgagg  ctccagccc  gcctctgat  gactagagg  cattgtcac  gtgacagag  1200
agctggagg  actgcagtt  cctcaggaa  ctgtggaga  cgagtctcg  ggggcgatc  1260
actccatcc  catcacaga  gatggggga  gaggaagct  taccccaga  gacccagca  1320
aggccccca  gactcctct  gaatcagaa  cccaatccg  tgcaccacc  accgggtcc  1380
cagaagagg  aggcgaagc  ctggaggaa  aagaaagat  caaagacac  gagactccg  1440
aggaagaga  ggagcagga  aacctgtgg  tgtggccca  ggagctcag  agccctctc  1500
ctactggct  ggaaacaga  cactcactc  cccaggtgt  cccaccagc  caggcagtt  1560
tacagctgg  tgcatcacc  tctcccagg  ctccaaggg  ccatggacc  cctgcagag  1620
ctttgcaac  cccaaggga  ggaagcctc  catctactc  agatggggc  agagaagta  1680
cgggggaaa  tgggagccc  gagctctct  gggttcctc  agaaagcga  gaggcagga  1740
gctccagct  ggaggatgg  ccttccctc  ttccagcga  atgggcccc  gtgggtacc  1800
gggagctgg  gaccccctc  gaagagaag  ctggaagaa  tgttctgac  ggcacatca  1860
tgcaggccc  gccagtgct  cccaccgac  gtgccagcc  aggtggagt  gctgtggct  1920
cctcatcag  tgactgtat  cccagcccc  gccacaatg  tgggacatg  ttggaggag  1980
aggagggtt  ccgctgcct  tgtttgcca  gctatgggg  ggacctgtg  gatgttggc  2040
tccacttct  cagcccggg  tgggaggcc  tccagggtg  ctgctacaa  cacttttcc  2100
cacgaagga  ttgggagga  gcagaaagc  agtgccgag  gctaggggc  catctgacc  2160
gcatctgca  ccctgagga  caggacttt  tcaacgatc  atacaggga  taccagtgg  2220
ttgggctca  tgacaggac  atcgagggt  acttcctgt  gtcagatgg  gcccctctg  2280
tctatgaaa  ctggaaccc  gggcagcct  acagctact  cctgtctgg  gagaactgt  2340
tggtcatgg  gtggcatga  cagggacag  ggagtgatg  accctgcaa  taccaccta  2400
cctacacct  caagatggg  cttgtgtca  gtggacctc  accacagct  cccctggct  2460
aaatatttg  tcgccctcg  ctggcctac  cggtggaca  tgtgcttcg  tatcggtgc  2520
gagacgggc  ggcccagcg  aacttgccg  tgatccgct  ccaggagaa  gggctttgg  2580
aggcccctc  gatttcttg  gtgccccga  gacctgccc  tgctctccg  tcaatgacc  2640
ccccagaag  accacgggg  cagctcccg  ggcagagga  agcactgtt  acacctccc  2700
ccagtctct  gggaacagg  gtggaagac  actgccccc  ccagggccc  ctcacttca  2760
ctgcctgtg  tcttcccta  gataggggg  tgacaagag  ggggtggga  tggaattca  2820
aggacaagc  acccgaagg  gtttctggg  aacacttgg  tgactccgc  caacctaga  2880
cccgccccc  catacaagg  cctcaggtt  tacccggta  gtccctaag  gcctcaact  2940
ccttctgct  tcagctgcc  ccttgtttc  cgatttctt  aggggacac  gtgctactc  3000
ttcttaatt  tcaaagggt  tttaggatg  agtaccagc  aaaccaggt  gaaataaag  3060
tgtttgaac  tcgtgcc  3077



<210> 8512
<211> 883
<212> PRT
<213> Rattus norvegicus
<308> P55068
<400> 8512

Met Ile Pro Leu Leu Leu Ser Leu Leu Ala Ala Leu Val Leu Thr Gln 
  1               5                  10                  15
Ala Pro Ala Ala Leu Ala Asp Asp Leu Lys Glu Asp Ser Ser Glu Asp 
             20                  25                  30
Arg Ala Phe Arg Val Arg Ile Gly Ala Ala Gln Leu Arg Gly Val Leu 
         35                  40                  45
Gly Gly Ala Leu Ala Ile Pro Cys His Val His His Leu Arg Pro Pro 
     50                  55                  60
Pro Ser Arg Arg Ala Ala Pro Gly Phe Pro Arg Val Lys Trp Thr Phe 
 65                  70                  75                  80
Leu Ser Gly Asp Arg Glu Val Glu Val Leu Val Ala Arg Gly Leu Arg 
                 85                  90                  95
Val Lys Val Asn Glu Ala Tyr Arg Phe Arg Val Ala Leu Pro Ala Tyr 
             100                105                110
Pro Ala Ser Leu Thr Asp Val Ser Leu Val Leu Ser Glu Leu Arg Pro 
         115                120                125
Asn Asp Ser Gly Val Tyr Arg Cys Glu Val Gln His Gly Ile Asp Asp 
     130                135                140
Ser Ser Asp Ala Val Glu Val Lys Val Lys Gly Val Val Phe Leu Tyr 
 145                150                155                160
Arg Glu Gly Ser Ala Arg Tyr Ala Phe Ser Phe Ala Gly Ala Gln Glu 
                 165                170                175
Ala Cys Ala Arg Ile Gly Ala Arg Ile Ala Thr Pro Glu Gln Leu Tyr 
             180                185                190
Ala Ala Tyr Leu Gly Gly Tyr Glu Gln Cys Asp Ala Gly Trp Leu Ser 
         195                200                205
Asp Gln Thr Val Arg Tyr Pro Ile Gln Asn Pro Arg Glu Ala Cys Tyr 
     210                215                220
Gly Asp Met Asp Gly Tyr Pro Gly Val Arg Asn Tyr Gly Val Val Gly 
 225                230                235                240
Pro Asp Asp Leu Tyr Asp Val Tyr Cys Tyr Ala Glu Asp Leu Asn Gly 
                 245                250                255
Glu Leu Phe Leu Gly Ala Pro Pro Gly Lys Leu Thr Trp Glu Glu Ala 
             260                265                270
Arg Asp Tyr Cys Leu Glu Arg Gly Ala Gln Ile Ala Ser Thr Gly Gln 
         275                280                285
Leu Tyr Ala Ala Trp Asn Gly Gly Leu Asp Arg Cys Ser Pro Gly Trp 
     290                295                300
Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Ile Thr Pro Ser Gln Arg 
 305                310                315                320
Cys Gly Gly Gly Leu Pro Gly Val Lys Thr Leu Phe Leu Phe Pro Asn 
                 325                330                335
Gln Thr Gly Phe Pro Ser Lys Gln Asn Arg Phe Asn Val Tyr Cys Phe 
             340                345                350
Arg Asp Ser Ala His Pro Ser Ala Phe Ser Glu Ala Ser Ser Pro Ala 
         355                360                365
Ser Asp Gly Leu Glu Ala Ile Val Thr Val Thr Glu Lys Leu Glu Glu 
     370                375                380
Leu Gln Leu Pro Gln Glu Ala Val Glu Ser Glu Ser Arg Gly Ala Ile 
 385                390                395                400
Tyr Ser Ile Pro Ile Thr Glu Asp Gly Gly Gly Gly Ser Ser Thr Pro 
                 405                410                415
Glu Asp Pro Ala Glu Ala Pro Arg Thr Pro Leu Glu Ser Glu Thr Gln 
             420                425                430
Ser Val Ala Pro Pro Thr Gly Ser Ser Glu Glu Glu Gly Glu Ala Leu 
         435                440                445
Glu Glu Glu Glu Arg Phe Lys Asp Thr Glu Thr Pro Lys Glu Glu Lys 
     450                455                460
Glu Gln Glu Asn Leu Trp Val Trp Pro Thr Glu Leu Ser Ser Pro Leu 
 465                470                475                480
Pro Thr Gly Leu Glu Thr Glu His Ser Leu Ser Gln Val Ser Pro Pro 
                 485                490                495
Ala Gln Ala Val Leu Gln Val Gly Ala Ser Pro Ser Pro Arg Pro Pro 
             500                505                510
Arg Val His Gly Pro Thr Val Glu Thr Leu Gln Pro Pro Gly Glu Gly 
         515                520                525
Ser Leu Thr Ser Thr Pro Asp Gly Ala Arg Glu Val Gly Gly Glu Thr 
     530                535                540
Gly Ser Pro Glu Leu Ser Gly Val Pro Arg Glu Arg Glu Glu Ala Gly 
 545                550                555                560
Ser Ser Ser Leu Glu Asp Gly Pro Ser Leu Leu Pro Glu Thr Trp Ala 
                 565                570                575
Pro Val Gly Thr Arg Glu Val Glu Thr Pro Ser Glu Glu Lys Ser Gly 
             580                585                590
Arg Thr Val Leu Thr Gly Thr Ser Val Gln Ala Gln Pro Val Leu Pro 
         595                600                605
Thr Asp Ser Ala Ser Arg Gly Gly Val Ala Val Ala Pro Ser Ser Gly 
     610                615                620
Asp Cys Ile Pro Ser Pro Cys His Asn Gly Gly Thr Cys Leu Glu Glu 
 625                630                635                640
Lys Glu Gly Phe Arg Cys Leu Cys Val Pro Gly Tyr Gly Gly Asp Leu 
                 645                650                655
Cys Asp Val Gly Leu His Phe Cys Ser Pro Gly Trp Glu Pro Phe Gln 
             660                665                670
Gly Ala Cys Tyr Lys His Phe Ser Thr Arg Arg Ser Trp Glu Glu Ala 
         675                680                685
Glu Ser Gln Cys Arg Ala Leu Gly Ala His Leu Thr Ser Ile Cys Thr 
     690                695                700
Pro Glu Glu Gln Asp Phe Val Asn Asp Arg Tyr Arg Glu Tyr Gln Trp 
 705                710                715                720
Ile Gly Leu Asn Asp Arg Thr Ile Glu Gly Asp Phe Leu Trp Ser Asp 
                 725                730                735
Gly Pro Pro Leu Leu Tyr Glu Asn Trp Asn Pro Gly Gln Pro Asp Ser 
             740                745                750
Tyr Phe Leu Ser Gly Glu Asn Cys Val Val Met Val Trp His Asp Gln 
         755                760                765
Gly Gln Trp Ser Asp Val Pro Cys Asn Tyr His Leu Ser Tyr Thr Cys 
     770                775                780
Lys Met Gly Leu Val Ser Cys Gly Pro Pro Pro Gln Leu Pro Leu Ala 
 785                790                795                800
Gln Ile Phe Gly Arg Pro Arg Leu Arg Tyr Ala Val Asp Thr Val Leu 
                 805                810                815
Arg Tyr Arg Cys Arg Asp Gly Leu Ala Gln Arg Asn Leu Pro Leu Ile 
             820                825                830
Arg Cys Gln Glu Asn Gly Leu Trp Glu Ala Pro Gln Ile Ser Cys Val 
         835                840                845
Pro Arg Arg Pro Ala Arg Ala Leu Arg Ser Met Thr Ala Pro Glu Gly 
     850                855                860
Pro Arg Gly Gln Leu Pro Arg Gln Arg Lys Ala Leu Leu Thr Pro Pro 
 865                870                875                880
Ser Ser Leu 
                 885



<210> 8513
<211> 3275
<212> DNA
<213> Homo sapiens
<308> NM_021948
<400> 8513

gcagtctcc  ccgcagtct  agctgcagc  gcaggactg  gccgtgcac  cggaggaga  60
ccccggagg  ggcgacaaa  ttcgcagtg  cgcgaccca  ccccagccc  gggtagcct  120
cagcatggc  cagctgttc  tgcccctgc  ggcagccct  gtcctggcc  aggctcctg  180
agctttagc  gatgttctg  aaggagaca  ctcagagga  cgcgctttt  gcgtgcgca  240
cgcgggcga  gcgccactg  agggcgtgc  cggcggcgc  ctcaccatc  cttgccacg  300
ccactacct  cggccaccg  cgagccgcc  ggctgtgct  ggctctccg  gggtcaagt  360
gactttcct  tcccggggc  gggaggcag  ggtgctggt  gcgcgggga  tgcgcgtca  420
ggtgaacga  gcctaccgg  tccgcgtgg  actgcctgc  tacccagcg  cgctcaccg  480
cgtctccct  gcgctgagc  agctgcgcc  caacgactc  ggtatctat  gctgtgagg  540
ccagcacgg  atcgatgac  gcagcgacg  tgtggaggt  aaggtcaaa  gggtcgtct  600
tctctaccg  gagggctct  cccgctatg  tttctcctt  tctggggcc  aggaggcct  660
tgcccgcat  ggagcccac  tcgccaccc  ggagcagct  tatgccgcc  accttgggg  720
ctatgagca  tgtgatgct  gctggctgt  ggatcagac  gtgaggtat  ccatccaga  780
cccacgaga  gcctgttac  gagacatgg  tggcttccc  ggggtccgg  actatggtg  840
ggtggaccc  gatgacctc  atgatgtgt  ctgttatgc  gaagaccta  atggagaac  900
gttcctggg  gaccctcca  agaagctga  attggagga  gcacgggcg  actgccagg  960
gcggggtgc  gagattgcc  ccacgggcc  actgtatgc  gcctgggat  gtggcctgg  1020
ccactgcag  ccagggtgg  tagctgatg  cagtgtgcg  taccccatc  tcacaccca  1080
ccagcgctg  ggtgggggc  tgcctggtg  caagactct  ttcctcttc  ccaaccaga  1140
tggcttccc  aataagcac  gccgcttca  cgtctactg  ttccgagac  cggcccagc  1200
ttctgccat  cctgaggcc  ccaacccag  ctccaaccc  gcctctgat  gactagagg  1260
tatcgtcac  gtgacagag  ccctggagg  actgcagct  cctcaggaa  ccacagaga  1320
tgaatcccg  ggggccatc  actccatcc  catcatgga  gacggagga  gtggaagct  1380
cactccaga  gacccagca  aggccccta  gacgctcct  gaatttgaa  cacaatcca  1440
ggtaccgcc  acggggttc  cagaagagg  aggtaaggc  ttggaggaa  aagagaaat  1500
tgaagatga  gaagagaaa  aggaggaag  agaagagga  gaggtggag  atgaggctc  1560
gtgggcatg  cccagcgag  tcagcagcc  gggccctga  gcctctctc  ccactgagc  1620
agcagccca  gagaagtca  tctcccagg  gccagcaag  gcagtcctg  agcctggtg  1680
atcaccact  cctgatgga  agtcagaag  ttccaggcc  ccaagggtc  atggaccac  1740
tactgagac  ctgcccact  ccagggaga  gaacctagc  tccccatca  cttccactc  1800
ggttgaggc  agagaggtg  gggaggcaa  tggtggtcc  gagctatct  gggtccctc  1860
aggagagag  gaggagaca  gaagctccg  gggtgcccc  tccctgctt  cagccacac  1920
ggcccctga  ggtaccagg  agctggagg  cccctctga  gataattct  gaagaactg  1980
cccagcagg  acctcagtg  aggcccagc  agtgctgcc  actgacagc  ccagccgag  2040
tggagtggc  gtggtcccc  catcaggtg  ctgtgtccc  agcccctgc  acaatggtg  2100
gacatgctt  gaggaggag  aaggggtcc  ctgcctatg  ctgcctggc  atggggggg  2160
cctgtgcga  gttggcctc  gcttctgca  ccccggctg  gacgccttc  agggcgcct  2220
ctacaagca  ttttccaca  gaaggagct  ggaggaggc  gagacccag  gccggatgt  2280
cggcgcgca  ctggccagc  tcagcacac  cgaggaaca  gacttcatc  acaaccggt  2340
ccgggagta  cagtggatc  gactcaacg  caggaccat  gaaggcgac  tcttgtggt  2400
ggatggcgt  cccctgctc  atgagaact  gaaccctgg  cagcctgac  gctacttcc  2460
gtctggaga  aactgcgtg  tcatggtgt  gcatgatca  ggacaatgg  gtgacgtgc  2520
ctgcaacta  cacctgtcc  acacctgca  gatggggct  gtgtcctgt  ggccgccac  2580
ggagctgcc  ctggctcaa  tgttcggcc  cccacggct  cgctatgag  tggacactg  2640
gcttcgcta  cggtgccgg  aaggactgg  ccagcgcaa  ctgccgctg  tccgatgcc  2700
agagaacgg  cgttgggag  ccccccaga  ctcctgtgt  cccagaaga  ctgcccgag  2760
tctgcaccc  gaggaggac  cagaaggac  tcaggggag  ctactggga  gctggaagg  2820
gctgttgat  cccccttcc  gccccatgc  aggtcccta  ggggcaagg  cttgaacac  2880
gccggccac  gcactgccc  gtcacccaa  ttttccctc  caccctgcg  tcccgccac  2940
acaggaagt  acaacatga  gaggggtgg  gctggagtc  aggtgacag  tcctgaagg  3000
gcttctggg  aatacctag  aggctccag  ccagcccag  ccctctccc  ctaccctgg  3060
caccagatc  tccatcagg  ccggagtaa  tccctaagt  cctcaactg  cctctccct  3120
gcagccatc  tgtcccctc  attcctcta  ggagcactg  gcccactct  tctgggttt  3180
ccaagggaa  gggcttgca  gatggagtg  ctgtaaaat  aacaggaaa  aaaactgtg  3240
atgagccca  gcaaaaaaa  aaaaaaaaa  aaaaa  3275



<210> 8514
<211> 911
<212> PRT
<213> Homo sapiens
<308> NP_068767
<400> 8514

Met Ala Gln Leu Phe Leu Pro Leu Leu Ala Ala Leu Val Leu Ala Gln 
  1               5                  10                  15
Ala Pro Ala Ala Leu Ala Asp Val Leu Glu Gly Asp Ser Ser Glu Asp 
             20                  25                  30
Arg Ala Phe Arg Val Arg Ile Ala Gly Asp Ala Pro Leu Gln Gly Val 
         35                  40                  45
Leu Gly Gly Ala Leu Thr Ile Pro Cys His Val His Tyr Leu Arg Pro 
     50                  55                  60
Pro Pro Ser Arg Arg Ala Val Leu Gly Ser Pro Arg Val Lys Trp Thr 
 65                  70                  75                  80
Phe Leu Ser Arg Gly Arg Glu Ala Glu Val Leu Val Ala Arg Gly Val 
                 85                  90                  95
Arg Val Lys Val Asn Glu Ala Tyr Arg Phe Arg Val Ala Leu Pro Ala 
             100                105                110
Tyr Pro Ala Ser Leu Thr Asp Val Ser Leu Ala Leu Ser Glu Leu Arg 
         115                120                125
Pro Asn Asp Ser Gly Ile Tyr Arg Cys Glu Val Gln His Gly Ile Asp 
     130                135                140
Asp Ser Ser Asp Ala Val Glu Val Lys Val Lys Gly Val Val Phe Leu 
 145                150                155                160
Tyr Arg Glu Gly Ser Ala Arg Tyr Ala Phe Ser Phe Ser Gly Ala Gln 
                 165                170                175
Glu Ala Cys Ala Arg Ile Gly Ala His Ile Ala Thr Pro Glu Gln Leu 
             180                185                190
Tyr Ala Ala Tyr Leu Gly Gly Tyr Glu Gln Cys Asp Ala Gly Trp Leu 
         195                200                205
Ser Asp Gln Thr Val Arg Tyr Pro Ile Gln Thr Pro Arg Glu Ala Cys 
     210                215                220
Tyr Gly Asp Met Asp Gly Phe Pro Gly Val Arg Asn Tyr Gly Val Val 
 225                230                235                240
Asp Pro Asp Asp Leu Tyr Asp Val Tyr Cys Tyr Ala Glu Asp Leu Asn 
                 245                250                255
Gly Glu Leu Phe Leu Gly Asp Pro Pro Glu Lys Leu Thr Leu Glu Glu 
             260                265                270
Ala Arg Ala Tyr Cys Gln Glu Arg Gly Ala Glu Ile Ala Thr Thr Gly 
         275                280                285
Gln Leu Tyr Ala Ala Trp Asp Gly Gly Leu Asp His Cys Ser Pro Gly 
     290                295                300
Trp Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Val Thr Pro Ser Gln 
 305                310                315                320
Arg Cys Gly Gly Gly Leu Pro Gly Val Lys Thr Leu Phe Leu Phe Pro 
                 325                330                335
Asn Gln Thr Gly Phe Pro Asn Lys His Ser Arg Phe Asn Val Tyr Cys 
             340                345                350
Phe Arg Asp Ser Ala Gln Pro Ser Ala Ile Pro Glu Ala Ser Asn Pro 
         355                360                365
Ala Ser Asn Pro Ala Ser Asp Gly Leu Glu Ala Ile Val Thr Val Thr 
     370                375                380
Glu Thr Leu Glu Glu Leu Gln Leu Pro Gln Glu Ala Thr Glu Ser Glu 
 385                390                395                400
Ser Arg Gly Ala Ile Tyr Ser Ile Pro Ile Met Glu Asp Gly Gly Gly 
                 405                410                415
Gly Ser Ser Thr Pro Glu Asp Pro Ala Glu Ala Pro Arg Thr Leu Leu 
             420                425                430
Glu Phe Glu Thr Gln Ser Met Val Pro Pro Thr Gly Phe Ser Glu Glu 
         435                440                445
Glu Gly Lys Ala Leu Glu Glu Glu Glu Lys Tyr Glu Asp Glu Glu Glu 
     450                455                460
Lys Glu Glu Glu Glu Glu Glu Glu Glu Val Glu Asp Glu Ala Leu Trp 
 465                470                475                480
Ala Trp Pro Ser Glu Leu Ser Ser Pro Gly Pro Glu Ala Ser Leu Pro 
                 485                490                495
Thr Glu Pro Ala Ala Gln Glu Lys Ser Leu Ser Gln Ala Pro Ala Arg 
             500                505                510
Ala Val Leu Gln Pro Gly Ala Ser Pro Leu Pro Asp Gly Glu Ser Glu 
         515                520                525
Ala Ser Arg Pro Pro Arg Val His Gly Pro Pro Thr Glu Thr Leu Pro 
     530                535                540
Thr Pro Arg Glu Arg Asn Leu Ala Ser Pro Ser Pro Ser Thr Leu Val 
 545                550                555                560
Glu Ala Arg Glu Val Gly Glu Ala Thr Gly Gly Pro Glu Leu Ser Gly 
                 565                570                575
Val Pro Arg Gly Glu Ser Glu Glu Thr Gly Ser Ser Glu Gly Ala Pro 
             580                585                590
Ser Leu Leu Pro Ala Thr Arg Ala Pro Glu Gly Thr Arg Glu Leu Glu 
         595                600                605
Ala Pro Ser Glu Asp Asn Ser Gly Arg Thr Ala Pro Ala Gly Thr Ser 
     610                615                620
Val Gln Ala Gln Pro Val Leu Pro Thr Asp Ser Ala Ser Arg Gly Gly 
 625                630                635                640
Val Ala Val Val Pro Ala Ser Gly Asp Cys Val Pro Ser Pro Cys His 
                 645                650                655
Asn Gly Gly Thr Cys Leu Glu Glu Glu Glu Gly Val Arg Cys Leu Cys 
             660                665                670
Leu Pro Gly Tyr Gly Gly Asp Leu Cys Asp Val Gly Leu Arg Phe Cys 
         675                680                685
Asn Pro Gly Trp Asp Ala Phe Gln Gly Ala Cys Tyr Lys His Phe Ser 
     690                695                700
Thr Arg Arg Ser Trp Glu Glu Ala Glu Thr Gln Cys Arg Met Tyr Gly 
 705                710                715                720
Ala His Leu Ala Ser Ile Ser Thr Pro Glu Glu Gln Asp Phe Ile Asn 
                 725                730                735
Asn Arg Tyr Arg Glu Tyr Gln Trp Ile Gly Leu Asn Asp Arg Thr Ile 
             740                745                750
Glu Gly Asp Phe Leu Trp Ser Asp Gly Val Pro Leu Leu Tyr Glu Asn 
         755                760                765
Trp Asn Pro Gly Gln Pro Asp Ser Tyr Phe Leu Ser Gly Glu Asn Cys 
     770                775                780
Val Val Met Val Trp His Asp Gln Gly Gln Trp Ser Asp Val Pro Cys 
 785                790                795                800
Asn Tyr His Leu Ser Tyr Thr Cys Lys Met Gly Leu Val Ser Cys Gly 
                 805                810                815
Pro Pro Pro Glu Leu Pro Leu Ala Gln Val Phe Gly Arg Pro Arg Leu 
             820                825                830
Arg Tyr Glu Val Asp Thr Val Leu Arg Tyr Arg Cys Arg Glu Gly Leu 
         835                840                845
Ala Gln Arg Asn Leu Pro Leu Ile Arg Cys Gln Glu Asn Gly Arg Trp 
     850                855                860
Glu Ala Pro Gln Ile Ser Cys Val Pro Arg Arg Pro Ala Arg Ala Leu 
 865                870                875                880
His Pro Glu Glu Asp Pro Glu Gly Arg Gln Gly Arg Leu Leu Gly Arg 
                 885                890                895
Trp Lys Ala Leu Leu Ile Pro Pro Ser Ser Pro Met Pro Gly Pro 
             900                905                910



<210> 8515
<211> 1742
<212> DNA
<213> Rattus norvegicus
<308> U37464
<400> 8515

atacattcc  cttgtcact  cttggggct  ctaagtagg  gccagtcgg  actccttgc  60
gcaggatgt  agacccttt  acctgtaat  ctgtggctg  cccttggcc  ctttcgtgc  120
atggagaac  aggtgctgg  gattcggat  aagattcca  atagtggcg  ggtggactg  180
accgtgcac  ccgggccgc  gttactctt  agggacgtg  tggatgtga  aggccaggt  240
ctgcctgaa  caacgacga  agcctttga  tatgaagat  aagatggtg  taggattac  300
gtaagaagt  acgaagaga  gaaggcaat  ctgtcctac  attattcca  agtaatgga  360
cagcaagta  atggccagc  aatagagcc  ctgcagatc  ttccaagag  ctgcaagcc  420
cctggggaa  ggaacatac  tggcctgaa  gtgaataca  gggctggac  atctcagca  480
accagccct  tggtctcag  ttcacttcc  agcaatagc  tgaagaagt  ctcggctga  540
ctgagaaag  tactggcca  cggccagat  aatgaacaa  acatacggt  tcgagacac  600
cttggtcat  gcaacggag  cacagtcta  aaagcatat  atgtcccaa  tgggaaaat  660
ttagctgta  aggttattc  gttagacat  acactggag  ttcagaagc  gatcatgtc  720
gagttggaa  ttctttata  gtgtgactc  tcgtatatc  taggatttt  cggggcatt  780
tttgtagaa  acaggattt  gatttgtac  gaattcatg  atggggggt  tttggatgt  840
tataggaaa  ttccagagc  cgtcctcgg  agaattgca  tagcagttg  taaaggcct  900
acctatctg  ggagtttaa  gattttaca  agagatgtg  agccttcca  catgcttgt  960
aacacaagc  gacaggtca  gctgtgtga  ttcggcgtg  gcacccagc  ggtgaattc  1020
atagccaag  cgtatgttg  aacaaatgc  tatatggca  ccgaaagga  ttcaggaga  1080
cagtatggg  tccattccg  cgtgtggag  ttagggatc  ctttcatgg  gattcagaa  1140
aaccaggga  ctttaatgc  tctccagct  ctgcagtgc  ttgttgatg  ggattcgcc  1200
gtccttccg  ttggagagt  ctcggagcc  tttgtacat  tcatcactc  gtgcatgag  1260
aagcagccc  aggaaagac  agcgcccga  gagctgatg  gtcacccat  catcgtgca  1320
ttcaatgac  gaaacgcca  tgtggtgtc  atgtgggtt  gccgagctc  ggaggagag  1380
cggagccag  aggggcccc  atgagacct  agcaggaca  tgaccaccc  ggaccaggc  1440
tcaaggtca  aacaagccg  gacccctct  tctgctgcc  gattgggaa  agatgtact  1500
ggcacagct  ctgctttca  cttctacct  acctgggag  cttcaagaa  ggtggtctc  1560
gccgaaccc  tcaccactg  tagggagga  gcactgaca  tggcaggtg  agatggtgc  1620
gggttgggg  gatgaggtt  tggaacctc  tctggcccc  ccctcatct  tccctactg  1680
tgtaaaggg  cagcctatc  gcagcactg  tgggaataa  gtattactg  tttggattg  1740
ag  1742



<210> 8516
<211> 448
<212> PRT
<213> Rattus norvegicus
<308> Q62862
<400> 8516

Met Leu Trp Leu Ala Leu Gly Pro Phe Arg Ala Met Glu Asn Gln Val 
  1               5                  10                  15
Leu Val Ile Arg Ile Lys Ile Pro Asn Ser Gly Ala Val Asp Trp Thr 
             20                  25                  30
Val His Ser Gly Pro Gln Leu Leu Phe Arg Asp Val Leu Asp Val Ile 
         35                  40                  45
Gly Gln Val Leu Pro Glu Ala Thr Thr Thr Ala Phe Glu Tyr Glu Asp 
     50                  55                  60
Glu Asp Gly Asp Arg Ile Thr Val Arg Ser Asp Glu Glu Met Lys Ala 
 65                  70                  75                  80
Met Leu Ser Tyr Tyr Tyr Ser Thr Val Met Glu Gln Gln Val Asn Gly 
                 85                  90                  95
Gln Leu Ile Glu Pro Leu Gln Ile Phe Pro Arg Ala Cys Lys Pro Pro 
             100                105                110
Gly Glu Arg Asn Ile His Gly Leu Lys Val Asn Thr Arg Ala Gly Pro 
         115                120                125
Ser Gln His Thr Ser Pro Val Val Ser Asp Ser Leu Pro Ser Asn Ser 
     130                135                140
Leu Lys Lys Ser Ser Ala Glu Leu Arg Lys Ile Leu Ala Asn Gly Gln 
 145                150                155                160
Met Asn Glu Gln Asp Ile Arg Tyr Arg Asp Thr Leu Gly His Gly Asn 
                 165                170                175
Gly Gly Thr Val Tyr Lys Ala Tyr His Val Pro Ser Gly Lys Ile Leu 
             180                185                190
Ala Val Lys Val Ile Leu Leu Asp Ile Thr Leu Glu Leu Gln Lys Gln 
         195                200                205
Ile Met Ser Glu Leu Glu Ile Leu Tyr Lys Cys Asp Ser Ser Tyr Ile 
     210                215                220
Ile Gly Phe Tyr Gly Ala Phe Phe Val Glu Asn Arg Ile Ser Ile Cys 
 225                230                235                240
Thr Glu Phe Met Asp Gly Gly Ser Leu Asp Val Tyr Arg Lys Ile Pro 
                 245                250                255
Glu His Val Leu Gly Arg Ile Ala Val Ala Val Val Lys Gly Leu Thr 
             260                265                270
Tyr Leu Trp Ser Leu Lys Ile Leu His Arg Asp Val Lys Pro Ser Asn 
         275                280                285
Met Leu Val Asn Thr Ser Gly Gln Val Lys Leu Cys Asp Phe Gly Val 
     290                295                300
Ser Thr Gln Leu Val Asn Ser Ile Ala Lys Thr Tyr Val Gly Thr Asn 
 305                310                315                320
Ala Tyr Met Ala Pro Glu Arg Ile Ser Gly Glu Gln Tyr Gly Ile His 
                 325                330                335
Ser Asp Val Trp Ser Leu Gly Ile Ser Phe Met Glu Leu Ala Leu Gly 
             340                345                350
Arg Phe Pro Tyr Pro Gln Ile Gln Lys Asn Gln Gly Ser Leu Met Pro 
         355                360                365
Leu Gln Leu Leu Gln Cys Ile Val Asp Glu Asp Ser Pro Val Leu Pro 
     370                375                380
Leu Gly Glu Phe Ser Glu Pro Phe Val His Phe Ile Thr Gln Cys Met 
 385                390                395                400
Arg Lys Gln Pro Lys Glu Arg Pro Ala Pro Glu Glu Leu Met Gly His 
                 405                410                415
Pro Phe Ile Val Gln Phe Asn Asp Gly Asn Ala Thr Val Val Ser Met 
             420                425                430
Trp Val Cys Arg Ala Leu Glu Glu Arg Arg Ser Gln Gln Gly Pro Pro 
         435                440                445



<210> 8517
<211> 1611
<212> DNA
<213> Homo sapiens
<308> U71088
<400> 8517

ctgtaatgc  gtggctagc  cttggcccc  ttcctgcca  ggagaacca  gtgctggta  60
ttcgcatca  gatcccaaa  agtggcgcg  tggactgga  agtgcactc  gggccgcag  120
tactcttca  ggatgtgct  gatgtgata  gccaggttc  gcctgaagc  acaactaca  180
catttgaat  tgaagatga  gatggtgat  gaattacag  gagaagtga  gaggaaatg  240
aggcaatgc  gtcatatta  tattccaca  taatggaac  gcaagtaaa  ggacagtta  300
tagagcctc  gcagatatt  ccaagagcc  gcaagcctc  tggggaacg  aacatacat  360
gcctgaagg  gaatactcg  gccggaccc  ctcaacaca  cagcccagc  gtctcagat  420
cacttccaa  caatagctt  aagaagtct  ctgctgaac  gaaaaaaat  ctagccaat  480
gccagatga  tgaacaaga  atacgatat  gggacactc  tggtcatgg  aacggaggc  540
cagtctaca  agcatatca  gtcccgagt  ggaaaatat  agctgtaaa  gtcatacta  600
tagatatta  actggaact  cagaagcaa  ttatgtctg  attggaaat  ctttataag  660
gcgattcat  atatatcat  ggattttat  gagcatttt  tgtagaaaa  aggatttca  720
tatgtacag  attcatgga  gggggatct  tggatgtat  taggaaaat  ccagaacat  780
tccttggaa  aattgcagt  gcagttgtt  aaggcctta  ttatttgtg  agtttaaag  840
ttttacata  agacgtgaa  ccctccaat  tgctagtaa  cacaagagg  caggttaag  900
tgtgtgatt  tggagttag  actcagctg  tgaattcta  agccaagac  tatgttgga  960
caaatgctt  tatggcgcc  gaaaggatt  caggggagc  gtatggaat  cattctgat  1020
tctggagct  aggaatctc  tttatggag  ttcagaaaa  ccagggatc  ttaatgcct  1080
tccagcttc  gcagtgcat  gttgatgag  attcgcccg  ccttccagt  ggagagttc  1140
cggagccat  tgtacattt  atcactcag  gtatgcgaa  acagccaaa  gaaaggcca  1200
cacctgaag  attgatggg  cacccgttc  tcgtgcagt  caatgatgg  aatgccgcc  1260
tggtgtcca  gtgggtgtg  cgggcgctg  aggagaggc  gagcctggc  tccctgccc  1320
cgccttcac  ctctgtcag  ctagagggc  ctattctat  gtgtcacct  aatgctaga  1380
ctcgctgat  agcctcgac  gtgccttct  gttgccagc  atctgttgt  tgcccctcc  1440
ccgtgcctt  cttgaccct  gaaggtgcc  ctcccactg  cctttccta  taaaatgag  1500
aaattgcat  gcattgtct  agtaggtgt  attctattc  ggggggtgg  gtggggcag  1560
acagcaagg  ggaggattg  gaagacaat  gcaggcatg  tggggatgc  g  1611



<210> 8518
<211> 438
<212> PRT
<213> Homo sapiens
<308> Q13163
<400> 8518

Met Leu Trp Leu Ala Leu Gly Pro Phe Pro Ala Met Glu Asn Gln Val 
  1               5                  10                  15
Leu Val Ile Arg Ile Lys Ile Pro Asn Ser Gly Ala Val Asp Trp Thr 
             20                  25                  30
Val His Ser Gly Pro Gln Leu Leu Phe Arg Asp Val Leu Asp Val Ile 
         35                  40                  45
Gly Gln Val Leu Pro Glu Ala Thr Thr Thr Ala Phe Glu Tyr Glu Asp 
     50                  55                  60
Glu Asp Gly Asp Arg Ile Thr Val Arg Ser Asp Glu Glu Met Lys Ala 
 65                  70                  75                  80
Met Leu Ser Tyr Tyr Tyr Ser Thr Val Met Glu Gln Gln Val Asn Gly 
                 85                  90                  95
Gln Leu Ile Glu Pro Leu Gln Ile Phe Pro Arg Ala Cys Lys Pro Pro 
             100                105                110
Gly Glu Arg Asn Ile His Gly Leu Lys Val Asn Thr Arg Ala Gly Pro 
         115                120                125
Ser Gln His Ser Ser Pro Ala Val Ser Asp Ser Leu Pro Ser Asn Ser 
     130                135                140
Leu Lys Lys Ser Ser Ala Glu Leu Lys Lys Ile Leu Ala Asn Gly Gln 
 145                150                155                160
Met Asn Glu Gln Asp Ile Arg Tyr Arg Asp Thr Leu Gly His Gly Asn 
                 165                170                175
Gly Gly Thr Val Tyr Lys Ala Tyr His Val Pro Ser Gly Lys Ile Leu 
             180                185                190
Ala Val Lys Val Ile Leu Leu Asp Ile Thr Leu Glu Leu Gln Lys Gln 
         195                200                205
Ile Met Ser Glu Leu Glu Ile Leu Tyr Lys Cys Asp Ser Ser Tyr Ile 
     210                215                220
Ile Gly Phe Tyr Gly Ala Phe Phe Val Glu Asn Arg Ile Ser Ile Cys 
 225                230                235                240
Thr Glu Phe Met Asp Gly Gly Ser Leu Asp Val Tyr Arg Lys Met Pro 
                 245                250                255
Glu His Val Leu Gly Arg Ile Ala Val Ala Val Val Lys Gly Leu Thr 
             260                265                270
Tyr Leu Trp Ser Leu Lys Ile Leu His Arg Asp Val Lys Pro Ser Asn 
         275                280                285
Met Leu Val Asn Thr Arg Gly Gln Val Lys Leu Cys Asp Phe Gly Val 
     290                295                300
Ser Thr Gln Leu Val Asn Ser Ile Ala Lys Thr Tyr Val Gly Thr Asn 
 305                310                315                320
Ala Tyr Met Ala Pro Glu Arg Ile Ser Gly Glu Gln Tyr Gly Ile His 
                 325                330                335
Ser Asp Val Trp Ser Leu Gly Ile Ser Phe Met Glu Ile Gln Lys Asn 
             340                345                350
Gln Gly Ser Leu Met Pro Leu Gln Leu Leu Gln Cys Ile Val Asp Glu 
         355                360                365
Asp Ser Pro Val Leu Pro Val Gly Glu Phe Ser Glu Pro Phe Val His 
     370                375                380
Phe Ile Thr Gln Cys Met Arg Lys Gln Pro Lys Glu Arg Pro Ala Pro 
 385                390                395                400
Glu Glu Leu Met Gly His Pro Phe Ile Val Gln Phe Asn Asp Gly Asn 
                 405                410                415
Ala Ala Val Val Ser Met Trp Val Cys Arg Ala Leu Glu Glu Arg Arg 
             420                425                430
Ser Gln Gln Gly Pro Pro 
         435



<210> 8519
<211> 1470
<212> DNA
<213> Rattus norvegicus
<308> U38253
<400> 8519

gcggctacg  cgtgcgggg  gctgaggta  agccggggc  agtacggta  caggcggtg  60
acgagctgg  taagccaga  ttgtaaaaa  ggagtttca  gccgtagtt  tggccgtcg  120
tgggggatc  cggatgaca  acttgactt  cagcattcc  aagcctctg  ttccagttg  180
aaacaaacc  ttaatttgg  acccgctga  cctgcttga  cgagttgga  ttgaagaag  240
catcgtggt  acaaccaaa  atgtccaaa  ggctctgtg  gcagagttc  agatgaaat  300
gaagccaga  attgtgtgc  ttcctgatg  ggcagacat  gggactgca  attctctac  360
ccacatata  ccaaaactt  agactgatg  gctggtcct  ggctgcgat  tgataacag  420
tgttgcctt  cacgaggtt  tggacctgt  cagagctta  gatgcatca  ttgccatgt  480
aatgaggaa  ggacaagag  gcacagaac  agttccagg  cagaagggg  aaaaaaaaa  540
agtggagca  cgtgacttc  ttggagtgg  cagcacagg  aaaaggctg  tctttatgg  600
taatgaagc  gacttggat  aagagctgg  cattaaggg  tccatcctg  agaagcacc  660
taggataca  ttccagaca  gccttgtgg  tgctcatct  tactgcttg  agaaatatg  720
tgtggattt  ttaatggaa  ataagtcaa  cacttctat  cgaagcgaa  tgattccgt  780
cctagtaag  aaacagttt  cctcagcct  ctcacagca  aggcaggaa  acaaagaag  840
ggatctaaa  aaaaaggag  ccaagtctt  agatattta  agttttata  aaaaagaca  900
cactctgac  ttggctccc  atgatgcct  ctggaatgc  tttcgaaga  acaagtggg  960
agatttgtc  agatcacag  ttcgctgct  tgtccacat  atgaaggaa  gactttgct  1020
tcgagtaag  acactggga  tctacatgg  agccaacag  caggtaccc  aattgctgt  1080
tgttctttg  cctgaggaa  caatgatcc  tccatcagc  cagattgcc  acaaacacc  1140
gattggagc  gacagcctt  tcgggtcag  tacacaagt  ggagagaag  catctatta  1200
gcgatctgt  attggctca  cctgtgtca  cagagacag  gtaactgtt  ccaactgcc  1260
tctcatgaa  tctgtcacc  tgggagaag  gagcagcat  catggcagc  tcatcttca  1320
caacgccgt  gtcgaggcg  gcgcggaga  cagggactg  ttaattgga  gtggtcaga  1380
gattgaagc  aaagctaaa  gcatgaacg  ggtgatcgt  ggaaatgac  agctcatgg  1440
gatctgaat  ctgaacaag  ctgaccccac  1470



<210> 8520
<211> 452
<212> PRT
<213> Rattus norvegicus
<308> P70541
<400> 8520

Met Glu Phe Gln Ala Val Val Met Ala Val Gly Gly Gly Ser Arg Met 
  1               5                  10                  15
Thr Asp Leu Thr Ser Ser Ile Pro Lys Pro Leu Leu Pro Val Gly Asn 
             20                  25                  30
Lys Pro Leu Ile Trp Tyr Pro Leu Asn Leu Leu Glu Arg Val Gly Phe 
         35                  40                  45
Glu Glu Val Ile Val Val Thr Thr Lys Asp Val Gln Lys Ala Leu Cys 
     50                  55                  60
Ala Glu Phe Lys Met Lys Leu Lys Pro Asp Ile Val Cys Ile Pro Asp 
 65                  70                  75                  80
Glu Ala Asp Met Gly Thr Ala Asp Ser Leu Arg His Ile Tyr Pro Lys 
                 85                  90                  95
Leu Lys Thr Asp Val Leu Val Leu Gly Cys Asp Leu Ile Thr Asp Val 
             100                105                110
Ala Leu His Glu Val Val Asp Leu Phe Arg Ala Tyr Asp Ala Ser Leu 
         115                120                125
Ala Met Leu Met Arg Lys Gly Gln Glu Ser Thr Glu Pro Val Pro Gly 
     130                135                140
Gln Lys Gly Lys Lys Lys Thr Val Glu Gln Arg Asp Phe Ile Gly Val 
 145                150                155                160
Asp Ser Thr Gly Lys Arg Leu Leu Phe Met Ala Asn Glu Ala Asp Leu 
                 165                170                175
Asp Glu Glu Leu Val Ile Lys Gly Ser Ile Leu Gln Lys His Pro Arg 
             180                185                190
Ile His Phe Gln Thr Gly Leu Val Asp Ala His Leu Tyr Cys Leu Lys 
         195                200                205
Lys Tyr Val Val Asp Phe Leu Met Glu Asn Lys Ser Ile Thr Ser Ile 
     210                215                220
Arg Ser Glu Leu Ile Pro Tyr Leu Val Arg Lys Gln Phe Ser Ser Ala 
 225                230                235                240
Ser Ser Gln Gln Arg Gln Glu Asp Lys Glu Glu Asp Leu Lys Lys Lys 
                 245                250                255
Glu Pro Lys Ser Leu Asp Ile Tyr Ser Phe Ile Lys Lys Asp Asn Thr 
             260                265                270
Leu Thr Leu Ala Pro Tyr Asp Ala Cys Trp Asn Ala Phe Arg Arg Asp 
         275                280                285
Lys Trp Glu Asp Leu Ser Arg Ser Gln Val Arg Cys Tyr Val His Ile 
     290                295                300
Met Lys Glu Gly Leu Cys Ser Arg Val Ser Thr Leu Gly Leu Tyr Met 
 305                310                315                320
Glu Ala Asn Arg Gln Val Pro Lys Leu Leu Ser Val Leu Cys Pro Glu 
                 325                330                335
Glu Ser Met Ile His Pro Ser Ala Gln Ile Ala Asn Lys His Leu Ile 
             340                345                350
Gly Ala Asp Ser Leu Ile Gly Ser Asp Thr Gln Val Gly Glu Lys Ser 
         355                360                365
Ser Ile Lys Arg Ser Val Ile Gly Ser Ser Cys Val Ile Arg Asp Arg 
     370                375                380
Val Thr Val Thr Asn Cys Leu Leu Met Asn Ser Val Thr Val Gly Glu 
 385                390                395                400
Gly Ser Ser Ile His Gly Ser Val Ile Phe Asn Asn Ala Val Val Glu 
                 405                410                415
Ala Gly Ala Glu Ile Arg Asp Cys Leu Ile Gly Ser Gly Gln Arg Ile 
             420                425                430
Glu Ala Lys Ala Lys Arg Met Asn Glu Val Ile Val Gly Asn Asp Gln 
         435                440                445
Leu Met Glu Ile 
     450



<210> 8521
<211> 1580
<212> DNA
<213> Homo sapiens
<308> BC018728
<400> 8521

atcgctggg  gcggttgcg  cgtgccggg  gctgagtta  agctgtgac  tctgccctg  60
caggccgca  acaagctgg  tgacccggt  tgtaaaaat  gaatttcaa  cagtagtga  120
ggcagtagg  ggaggatct  ggatgacag  cctaacttc  agcattccc  aacctctgc  180
tccagttgg  aacaaacct  taatttggt  cccattgaa  ctgcttgag  gtgttggat  240
tgaagaagt  attgtggtt  caaccaggg  tgttcaaaa  gctctatgt  cagaattca  300
gatgaaaat  aagccagat  ttgtgtgta  tcctgatga  gctgacatg  gaactgcag  360
ttctttgcg  tacatatat  caaaactta  gacagatgt  ctggtgctg  gctgtgatc  420
gataacaga  gttgcctta  atgaggttg  ggacctgtt  agagcttat  atgcatcac  480
tgctatgtt  atgagaaaa  gccaagata  catagaacc  gttcccggt  aaaagggga  540
aaaaaaagc  gtggagcag  gtgacttca  tggagtgga  agcacagga  agaggctgc  600
cttcatggc  aatgaagca  acttggatg  agagctggt  attaaggga  ccatcctac  660
gaagcatcc  agaatacgt  tccacacgg  tcttgtgga  gcccacctc  actgtttga  720
aaaatacat  gtggatttc  taatggaaa  tgggtcaat  acttctatc  ggagtgaac  780
gattccata  ttagtgaga  aacagtttt  ctcagcttc  tcacaacag  gacaagaag  840
aaaagagga  gatctaaag  aaaaggagc  gaagtcctt  gatatctac  gttttataa  900
agaagccaa  acactgaac  tggctccct  tgatgcctg  tggaatgcc  gtcgaggag  960
caggtggga  gacttgtcc  gatcacagg  gcgctgcta  gtccacatc  tgaaagagg  1020
gctctgctc  cgagtgagc  cactgggac  ctacatgga  gcaaacaga  aggtgccca  1080
attgctgtc  gctctctgt  cagaagaac  accagtcca  tcgtcagcc  agattgtca  1140
caaacacct  gttggagtt  acagcctca  tgggccaga  acacagatt  gagagaagt  1200
atccattaa  cgctcagtc  ttggctcat  ctgtctcat  aaagataga  tgactatta  1260
caattgcct  ctcatgaac  cagtcactg  ggaggaagg  taaacgagt  aatgaggtg  1320
tcgtgggga  tgaccagct  atggagatc  gagttctga  caagtcaga  tccttcctt  1380
tggcctcca  agccacaga  gttggccgg  ccacctgtt  aactctgta  ttatttccc  1440
ataaagaag  gcttccaaa  gcatgctgg  gacttgtgg  gcagtccaa  gctccatgt  1500
aggtgggct  caggtgtac  cagtgtatg  tcatgtgtc  tgtggtaaa  atcatctgg  1560
gcaaaaaaa  aaaaaaaaaa  1580



<210> 8522
<211> 452
<212> PRT
<213> Homo sapiens
<308> Q9NR50
<400> 8522

Met Glu Phe Gln Ala Val Val Met Ala Val Gly Gly Gly Ser Arg Met 
  1               5                  10                  15
Thr Asp Leu Thr Ser Ser Ile Pro Lys Pro Leu Leu Pro Val Gly Asn 
             20                  25                  30
Lys Pro Leu Ile Trp Tyr Pro Leu Asn Leu Leu Glu Arg Val Gly Phe 
         35                  40                  45
Glu Glu Val Ile Val Val Thr Thr Arg Asp Val Gln Lys Ala Leu Cys 
     50                  55                  60
Ala Glu Phe Lys Met Lys Met Lys Pro Asp Ile Val Cys Ile Pro Asp 
 65                  70                  75                  80
Asp Ala Asp Met Gly Thr Ala Asp Ser Leu Arg Tyr Ile Tyr Pro Lys 
                 85                  90                  95
Leu Lys Thr Asp Val Leu Val Leu Ser Cys Asp Leu Ile Thr Asp Val 
             100                105                110
Ala Leu His Glu Val Val Asp Leu Phe Arg Ala Tyr Asp Ala Ser Leu 
         115                120                125
Ala Met Leu Met Arg Lys Gly Gln Asp Ser Ile Glu Pro Val Pro Gly 
     130                135                140
Gln Lys Gly Lys Lys Lys Ala Val Glu Gln Arg Asp Phe Ile Gly Val 
 145                150                155                160
Asp Ser Thr Gly Lys Arg Leu Leu Phe Met Ala Asn Glu Ala Asp Leu 
                 165                170                175
Asp Glu Glu Leu Val Ile Lys Gly Ser Ile Leu Gln Lys His Pro Arg 
             180                185                190
Ile Arg Phe His Thr Gly Leu Val Asp Ala His Leu Tyr Cys Leu Lys 
         195                200                205
Lys Tyr Ile Val Asp Phe Leu Met Glu Asn Gly Ser Ile Thr Ser Ile 
     210                215                220
Arg Ser Glu Leu Ile Pro Tyr Leu Val Arg Lys Gln Phe Ser Ser Ala 
 225                230                235                240
Ser Ser Gln Gln Gly Gln Glu Glu Lys Glu Glu Asp Leu Lys Lys Lys 
                 245                250                255
Glu Leu Lys Ser Leu Asp Ile Tyr Ser Phe Ile Lys Glu Ala Asn Thr 
             260                265                270
Leu Asn Leu Ala Pro Tyr Asp Ala Cys Trp Asn Ala Cys Arg Gly Asp 
         275                280                285
Arg Trp Glu Asp Leu Ser Arg Ser Gln Val Arg Cys Tyr Val His Ile 
     290                295                300
Met Lys Glu Gly Leu Cys Ser Arg Val Ser Thr Leu Gly Leu Tyr Met 
 305                310                315                320
Glu Ala Asn Arg Gln Val Pro Lys Leu Leu Ser Ala Leu Cys Pro Glu 
                 325                330                335
Glu Pro Pro Val His Ser Ser Ala Gln Ile Val Ser Lys His Leu Val 
             340                345                350
Gly Val Asp Ser Leu Ile Gly Pro Glu Thr Gln Ile Gly Glu Lys Ser 
         355                360                365
Ser Ile Lys Arg Ser Val Ile Gly Ser Ser Cys Leu Ile Lys Asp Arg 
     370                375                380
Val Thr Ile Thr Asn Cys Leu Leu Met Asn Ser Val Thr Val Glu Glu 
 385                390                395                400
Gly Ser Asn Ile Gln Gly Ser Val Ile Cys Asn Asn Ala Val Ile Glu 
                 405                410                415
Lys Gly Ala Asp Ile Lys Asp Cys Leu Ile Gly Ser Gly Gln Arg Ile 
             420                425                430
Glu Ala Lys Ala Lys Arg Val Asn Glu Val Ile Val Gly Asn Asp Gln 
         435                440                445
Leu Met Glu Ile 
     450



<210> 8523
<211> 1470
<212> DNA
<213> Rattus norvegicus
<308> U38253
<400> 8523

gcggctacg  cgtgcgggg  gctgaggta  agccggggc  agtacggta  caggcggtg  60
acgagctgg  taagccaga  ttgtaaaaa  ggagtttca  gccgtagtt  tggccgtcg  120
tgggggatc  cggatgaca  acttgactt  cagcattcc  aagcctctg  ttccagttg  180
aaacaaacc  ttaatttgg  acccgctga  cctgcttga  cgagttgga  ttgaagaag  240
catcgtggt  acaaccaaa  atgtccaaa  ggctctgtg  gcagagttc  agatgaaat  300
gaagccaga  attgtgtgc  ttcctgatg  ggcagacat  gggactgca  attctctac  360
ccacatata  ccaaaactt  agactgatg  gctggtcct  ggctgcgat  tgataacag  420
tgttgcctt  cacgaggtt  tggacctgt  cagagctta  gatgcatca  ttgccatgt  480
aatgaggaa  ggacaagag  gcacagaac  agttccagg  cagaagggg  aaaaaaaaa  540
agtggagca  cgtgacttc  ttggagtgg  cagcacagg  aaaaggctg  tctttatgg  600
taatgaagc  gacttggat  aagagctgg  cattaaggg  tccatcctg  agaagcacc  660
taggataca  ttccagaca  gccttgtgg  tgctcatct  tactgcttg  agaaatatg  720
tgtggattt  ttaatggaa  ataagtcaa  cacttctat  cgaagcgaa  tgattccgt  780
cctagtaag  aaacagttt  cctcagcct  ctcacagca  aggcaggaa  acaaagaag  840
ggatctaaa  aaaaaggag  ccaagtctt  agatattta  agttttata  aaaaagaca  900
cactctgac  ttggctccc  atgatgcct  ctggaatgc  tttcgaaga  acaagtggg  960
agatttgtc  agatcacag  ttcgctgct  tgtccacat  atgaaggaa  gactttgct  1020
tcgagtaag  acactggga  tctacatgg  agccaacag  caggtaccc  aattgctgt  1080
tgttctttg  cctgaggaa  caatgatcc  tccatcagc  cagattgcc  acaaacacc  1140
gattggagc  gacagcctt  tcgggtcag  tacacaagt  ggagagaag  catctatta  1200
gcgatctgt  attggctca  cctgtgtca  cagagacag  gtaactgtt  ccaactgcc  1260
tctcatgaa  tctgtcacc  tgggagaag  gagcagcat  catggcagc  tcatcttca  1320
caacgccgt  gtcgaggcg  gcgcggaga  cagggactg  ttaattgga  gtggtcaga  1380
gattgaagc  aaagctaaa  gcatgaacg  ggtgatcgt  ggaaatgac  agctcatgg  1440
gatctgaat  ctgaacaag  ctgaccccac  1470



<210> 8524
<211> 452
<212> PRT
<213> Rattus norvegicus
<308> P70541
<400> 8524

Met Glu Phe Gln Ala Val Val Met Ala Val Gly Gly Gly Ser Arg Met 
  1               5                  10                  15
Thr Asp Leu Thr Ser Ser Ile Pro Lys Pro Leu Leu Pro Val Gly Asn 
             20                  25                  30
Lys Pro Leu Ile Trp Tyr Pro Leu Asn Leu Leu Glu Arg Val Gly Phe 
         35                  40                  45
Glu Glu Val Ile Val Val Thr Thr Lys Asp Val Gln Lys Ala Leu Cys 
     50                  55                  60
Ala Glu Phe Lys Met Lys Leu Lys Pro Asp Ile Val Cys Ile Pro Asp 
 65                  70                  75                  80
Glu Ala Asp Met Gly Thr Ala Asp Ser Leu Arg His Ile Tyr Pro Lys 
                 85                  90                  95
Leu Lys Thr Asp Val Leu Val Leu Gly Cys Asp Leu Ile Thr Asp Val 
             100                105                110
Ala Leu His Glu Val Val Asp Leu Phe Arg Ala Tyr Asp Ala Ser Leu 
         115                120                125
Ala Met Leu Met Arg Lys Gly Gln Glu Ser Thr Glu Pro Val Pro Gly 
     130                135                140
Gln Lys Gly Lys Lys Lys Thr Val Glu Gln Arg Asp Phe Ile Gly Val 
 145                150                155                160
Asp Ser Thr Gly Lys Arg Leu Leu Phe Met Ala Asn Glu Ala Asp Leu 
                 165                170                175
Asp Glu Glu Leu Val Ile Lys Gly Ser Ile Leu Gln Lys His Pro Arg 
             180                185                190
Ile His Phe Gln Thr Gly Leu Val Asp Ala His Leu Tyr Cys Leu Lys 
         195                200                205
Lys Tyr Val Val Asp Phe Leu Met Glu Asn Lys Ser Ile Thr Ser Ile 
     210                215                220
Arg Ser Glu Leu Ile Pro Tyr Leu Val Arg Lys Gln Phe Ser Ser Ala 
 225                230                235                240
Ser Ser Gln Gln Arg Gln Glu Asp Lys Glu Glu Asp Leu Lys Lys Lys 
                 245                250                255
Glu Pro Lys Ser Leu Asp Ile Tyr Ser Phe Ile Lys Lys Asp Asn Thr 
             260                265                270
Leu Thr Leu Ala Pro Tyr Asp Ala Cys Trp Asn Ala Phe Arg Arg Asp 
         275                280                285
Lys Trp Glu Asp Leu Ser Arg Ser Gln Val Arg Cys Tyr Val His Ile 
     290                295                300
Met Lys Glu Gly Leu Cys Ser Arg Val Ser Thr Leu Gly Leu Tyr Met 
 305                310                315                320
Glu Ala Asn Arg Gln Val Pro Lys Leu Leu Ser Val Leu Cys Pro Glu 
                 325                330                335
Glu Ser Met Ile His Pro Ser Ala Gln Ile Ala Asn Lys His Leu Ile 
             340                345                350
Gly Ala Asp Ser Leu Ile Gly Ser Asp Thr Gln Val Gly Glu Lys Ser 
         355                360                365
Ser Ile Lys Arg Ser Val Ile Gly Ser Ser Cys Val Ile Arg Asp Arg 
     370                375                380
Val Thr Val Thr Asn Cys Leu Leu Met Asn Ser Val Thr Val Gly Glu 
 385                390                395                400
Gly Ser Ser Ile His Gly Ser Val Ile Phe Asn Asn Ala Val Val Glu 
                 405                410                415
Ala Gly Ala Glu Ile Arg Asp Cys Leu Ile Gly Ser Gly Gln Arg Ile 
             420                425                430
Glu Ala Lys Ala Lys Arg Met Asn Glu Val Ile Val Gly Asn Asp Gln 
         435                440                445
Leu Met Glu Ile 
     450



<210> 8525
<211> 1580
<212> DNA
<213> Homo sapiens
<308> BC018728
<400> 8525

atcgctggg  gcggttgcg  cgtgccggg  gctgagtta  agctgtgac  tctgccctg  60
caggccgca  acaagctgg  tgacccggt  tgtaaaaat  gaatttcaa  cagtagtga  120
ggcagtagg  ggaggatct  ggatgacag  cctaacttc  agcattccc  aacctctgc  180
tccagttgg  aacaaacct  taatttggt  cccattgaa  ctgcttgag  gtgttggat  240
tgaagaagt  attgtggtt  caaccaggg  tgttcaaaa  gctctatgt  cagaattca  300
gatgaaaat  aagccagat  ttgtgtgta  tcctgatga  gctgacatg  gaactgcag  360
ttctttgcg  tacatatat  caaaactta  gacagatgt  ctggtgctg  gctgtgatc  420
gataacaga  gttgcctta  atgaggttg  ggacctgtt  agagcttat  atgcatcac  480
tgctatgtt  atgagaaaa  gccaagata  catagaacc  gttcccggt  aaaagggga  540
aaaaaaagc  gtggagcag  gtgacttca  tggagtgga  agcacagga  agaggctgc  600
cttcatggc  aatgaagca  acttggatg  agagctggt  attaaggga  ccatcctac  660
gaagcatcc  agaatacgt  tccacacgg  tcttgtgga  gcccacctc  actgtttga  720
aaaatacat  gtggatttc  taatggaaa  tgggtcaat  acttctatc  ggagtgaac  780
gattccata  ttagtgaga  aacagtttt  ctcagcttc  tcacaacag  gacaagaag  840
aaaagagga  gatctaaag  aaaaggagc  gaagtcctt  gatatctac  gttttataa  900
agaagccaa  acactgaac  tggctccct  tgatgcctg  tggaatgcc  gtcgaggag  960
caggtggga  gacttgtcc  gatcacagg  gcgctgcta  gtccacatc  tgaaagagg  1020
gctctgctc  cgagtgagc  cactgggac  ctacatgga  gcaaacaga  aggtgccca  1080
attgctgtc  gctctctgt  cagaagaac  accagtcca  tcgtcagcc  agattgtca  1140
caaacacct  gttggagtt  acagcctca  tgggccaga  acacagatt  gagagaagt  1200
atccattaa  cgctcagtc  ttggctcat  ctgtctcat  aaagataga  tgactatta  1260
caattgcct  ctcatgaac  cagtcactg  ggaggaagg  taaacgagt  aatgaggtg  1320
tcgtgggga  tgaccagct  atggagatc  gagttctga  caagtcaga  tccttcctt  1380
tggcctcca  agccacaga  gttggccgg  ccacctgtt  aactctgta  ttatttccc  1440
ataaagaag  gcttccaaa  gcatgctgg  gacttgtgg  gcagtccaa  gctccatgt  1500
aggtgggct  caggtgtac  cagtgtatg  tcatgtgtc  tgtggtaaa  atcatctgg  1560
gcaaaaaaa  aaaaaaaaaa  1580



<210> 8526
<211> 452
<212> PRT
<213> Homo sapiens
<308> Q9NR50
<400> 8526

Met Glu Phe Gln Ala Val Val Met Ala Val Gly Gly Gly Ser Arg Met 
  1               5                  10                  15
Thr Asp Leu Thr Ser Ser Ile Pro Lys Pro Leu Leu Pro Val Gly Asn 
             20                  25                  30
Lys Pro Leu Ile Trp Tyr Pro Leu Asn Leu Leu Glu Arg Val Gly Phe 
         35                  40                  45
Glu Glu Val Ile Val Val Thr Thr Arg Asp Val Gln Lys Ala Leu Cys 
     50                  55                  60
Ala Glu Phe Lys Met Lys Met Lys Pro Asp Ile Val Cys Ile Pro Asp 
 65                  70                  75                  80
Asp Ala Asp Met Gly Thr Ala Asp Ser Leu Arg Tyr Ile Tyr Pro Lys 
                 85                  90                  95
Leu Lys Thr Asp Val Leu Val Leu Ser Cys Asp Leu Ile Thr Asp Val 
             100                105                110
Ala Leu His Glu Val Val Asp Leu Phe Arg Ala Tyr Asp Ala Ser Leu 
         115                120                125
Ala Met Leu Met Arg Lys Gly Gln Asp Ser Ile Glu Pro Val Pro Gly 
     130                135                140
Gln Lys Gly Lys Lys Lys Ala Val Glu Gln Arg Asp Phe Ile Gly Val 
 145                150                155                160
Asp Ser Thr Gly Lys Arg Leu Leu Phe Met Ala Asn Glu Ala Asp Leu 
                 165                170                175
Asp Glu Glu Leu Val Ile Lys Gly Ser Ile Leu Gln Lys His Pro Arg 
             180                185                190
Ile Arg Phe His Thr Gly Leu Val Asp Ala His Leu Tyr Cys Leu Lys 
         195                200                205
Lys Tyr Ile Val Asp Phe Leu Met Glu Asn Gly Ser Ile Thr Ser Ile 
     210                215                220
Arg Ser Glu Leu Ile Pro Tyr Leu Val Arg Lys Gln Phe Ser Ser Ala 
 225                230                235                240
Ser Ser Gln Gln Gly Gln Glu Glu Lys Glu Glu Asp Leu Lys Lys Lys 
                 245                250                255
Glu Leu Lys Ser Leu Asp Ile Tyr Ser Phe Ile Lys Glu Ala Asn Thr 
             260                265                270
Leu Asn Leu Ala Pro Tyr Asp Ala Cys Trp Asn Ala Cys Arg Gly Asp 
         275                280                285
Arg Trp Glu Asp Leu Ser Arg Ser Gln Val Arg Cys Tyr Val His Ile 
     290                295                300
Met Lys Glu Gly Leu Cys Ser Arg Val Ser Thr Leu Gly Leu Tyr Met 
 305                310                315                320
Glu Ala Asn Arg Gln Val Pro Lys Leu Leu Ser Ala Leu Cys Pro Glu 
                 325                330                335
Glu Pro Pro Val His Ser Ser Ala Gln Ile Val Ser Lys His Leu Val 
             340                345                350
Gly Val Asp Ser Leu Ile Gly Pro Glu Thr Gln Ile Gly Glu Lys Ser 
         355                360                365
Ser Ile Lys Arg Ser Val Ile Gly Ser Ser Cys Leu Ile Lys Asp Arg 
     370                375                380
Val Thr Ile Thr Asn Cys Leu Leu Met Asn Ser Val Thr Val Glu Glu 
 385                390                395                400
Gly Ser Asn Ile Gln Gly Ser Val Ile Cys Asn Asn Ala Val Ile Glu 
                 405                410                415
Lys Gly Ala Asp Ile Lys Asp Cys Leu Ile Gly Ser Gly Gln Arg Ile 
             420                425                430
Glu Ala Lys Ala Lys Arg Val Asn Glu Val Ile Val Gly Asn Asp Gln 
         435                440                445
Leu Met Glu Ile 
     450



<210> 8527
<211> 1470
<212> DNA
<213> Rattus norvegicus
<308> U38253
<400> 8527

gcggctacg  cgtgcgggg  gctgaggta  agccggggc  agtacggta  caggcggtg  60
acgagctgg  taagccaga  ttgtaaaaa  ggagtttca  gccgtagtt  tggccgtcg  120
tgggggatc  cggatgaca  acttgactt  cagcattcc  aagcctctg  ttccagttg  180
aaacaaacc  ttaatttgg  acccgctga  cctgcttga  cgagttgga  ttgaagaag  240
catcgtggt  acaaccaaa  atgtccaaa  ggctctgtg  gcagagttc  agatgaaat  300
gaagccaga  attgtgtgc  ttcctgatg  ggcagacat  gggactgca  attctctac  360
ccacatata  ccaaaactt  agactgatg  gctggtcct  ggctgcgat  tgataacag  420
tgttgcctt  cacgaggtt  tggacctgt  cagagctta  gatgcatca  ttgccatgt  480
aatgaggaa  ggacaagag  gcacagaac  agttccagg  cagaagggg  aaaaaaaaa  540
agtggagca  cgtgacttc  ttggagtgg  cagcacagg  aaaaggctg  tctttatgg  600
taatgaagc  gacttggat  aagagctgg  cattaaggg  tccatcctg  agaagcacc  660
taggataca  ttccagaca  gccttgtgg  tgctcatct  tactgcttg  agaaatatg  720
tgtggattt  ttaatggaa  ataagtcaa  cacttctat  cgaagcgaa  tgattccgt  780
cctagtaag  aaacagttt  cctcagcct  ctcacagca  aggcaggaa  acaaagaag  840
ggatctaaa  aaaaaggag  ccaagtctt  agatattta  agttttata  aaaaagaca  900
cactctgac  ttggctccc  atgatgcct  ctggaatgc  tttcgaaga  acaagtggg  960
agatttgtc  agatcacag  ttcgctgct  tgtccacat  atgaaggaa  gactttgct  1020
tcgagtaag  acactggga  tctacatgg  agccaacag  caggtaccc  aattgctgt  1080
tgttctttg  cctgaggaa  caatgatcc  tccatcagc  cagattgcc  acaaacacc  1140
gattggagc  gacagcctt  tcgggtcag  tacacaagt  ggagagaag  catctatta  1200
gcgatctgt  attggctca  cctgtgtca  cagagacag  gtaactgtt  ccaactgcc  1260
tctcatgaa  tctgtcacc  tgggagaag  gagcagcat  catggcagc  tcatcttca  1320
caacgccgt  gtcgaggcg  gcgcggaga  cagggactg  ttaattgga  gtggtcaga  1380
gattgaagc  aaagctaaa  gcatgaacg  ggtgatcgt  ggaaatgac  agctcatgg  1440
gatctgaat  ctgaacaag  ctgaccccac  1470



<210> 8528
<211> 452
<212> PRT
<213> Rattus norvegicus
<308> P70541
<400> 8528

Met Glu Phe Gln Ala Val Val Met Ala Val Gly Gly Gly Ser Arg Met 
  1               5                  10                  15
Thr Asp Leu Thr Ser Ser Ile Pro Lys Pro Leu Leu Pro Val Gly Asn 
             20                  25                  30
Lys Pro Leu Ile Trp Tyr Pro Leu Asn Leu Leu Glu Arg Val Gly Phe 
         35                  40                  45
Glu Glu Val Ile Val Val Thr Thr Lys Asp Val Gln Lys Ala Leu Cys 
     50                  55                  60
Ala Glu Phe Lys Met Lys Leu Lys Pro Asp Ile Val Cys Ile Pro Asp 
 65                  70                  75                  80
Glu Ala Asp Met Gly Thr Ala Asp Ser Leu Arg His Ile Tyr Pro Lys 
                 85                  90                  95
Leu Lys Thr Asp Val Leu Val Leu Gly Cys Asp Leu Ile Thr Asp Val 
             100                105                110
Ala Leu His Glu Val Val Asp Leu Phe Arg Ala Tyr Asp Ala Ser Leu 
         115                120                125
Ala Met Leu Met Arg Lys Gly Gln Glu Ser Thr Glu Pro Val Pro Gly 
     130                135                140
Gln Lys Gly Lys Lys Lys Thr Val Glu Gln Arg Asp Phe Ile Gly Val 
 145                150                155                160
Asp Ser Thr Gly Lys Arg Leu Leu Phe Met Ala Asn Glu Ala Asp Leu 
                 165                170                175
Asp Glu Glu Leu Val Ile Lys Gly Ser Ile Leu Gln Lys His Pro Arg 
             180                185                190
Ile His Phe Gln Thr Gly Leu Val Asp Ala His Leu Tyr Cys Leu Lys 
         195                200                205
Lys Tyr Val Val Asp Phe Leu Met Glu Asn Lys Ser Ile Thr Ser Ile 
     210                215                220
Arg Ser Glu Leu Ile Pro Tyr Leu Val Arg Lys Gln Phe Ser Ser Ala 
 225                230                235                240
Ser Ser Gln Gln Arg Gln Glu Asp Lys Glu Glu Asp Leu Lys Lys Lys 
                 245                250                255
Glu Pro Lys Ser Leu Asp Ile Tyr Ser Phe Ile Lys Lys Asp Asn Thr 
             260                265                270
Leu Thr Leu Ala Pro Tyr Asp Ala Cys Trp Asn Ala Phe Arg Arg Asp 
         275                280                285
Lys Trp Glu Asp Leu Ser Arg Ser Gln Val Arg Cys Tyr Val His Ile 
     290                295                300
Met Lys Glu Gly Leu Cys Ser Arg Val Ser Thr Leu Gly Leu Tyr Met 
 305                310                315                320
Glu Ala Asn Arg Gln Val Pro Lys Leu Leu Ser Val Leu Cys Pro Glu 
                 325                330                335
Glu Ser Met Ile His Pro Ser Ala Gln Ile Ala Asn Lys His Leu Ile 
             340                345                350
Gly Ala Asp Ser Leu Ile Gly Ser Asp Thr Gln Val Gly Glu Lys Ser 
         355                360                365
Ser Ile Lys Arg Ser Val Ile Gly Ser Ser Cys Val Ile Arg Asp Arg 
     370                375                380
Val Thr Val Thr Asn Cys Leu Leu Met Asn Ser Val Thr Val Gly Glu 
 385                390                395                400
Gly Ser Ser Ile His Gly Ser Val Ile Phe Asn Asn Ala Val Val Glu 
                 405                410                415
Ala Gly Ala Glu Ile Arg Asp Cys Leu Ile Gly Ser Gly Gln Arg Ile 
             420                425                430
Glu Ala Lys Ala Lys Arg Met Asn Glu Val Ile Val Gly Asn Asp Gln 
         435                440                445
Leu Met Glu Ile 
     450



<210> 8529
<211> 1580
<212> DNA
<213> Homo sapiens
<308> BC018728
<400> 8529

atcgctggg  gcggttgcg  cgtgccggg  gctgagtta  agctgtgac  tctgccctg  60
caggccgca  acaagctgg  tgacccggt  tgtaaaaat  gaatttcaa  cagtagtga  120
ggcagtagg  ggaggatct  ggatgacag  cctaacttc  agcattccc  aacctctgc  180
tccagttgg  aacaaacct  taatttggt  cccattgaa  ctgcttgag  gtgttggat  240
tgaagaagt  attgtggtt  caaccaggg  tgttcaaaa  gctctatgt  cagaattca  300
gatgaaaat  aagccagat  ttgtgtgta  tcctgatga  gctgacatg  gaactgcag  360
ttctttgcg  tacatatat  caaaactta  gacagatgt  ctggtgctg  gctgtgatc  420
gataacaga  gttgcctta  atgaggttg  ggacctgtt  agagcttat  atgcatcac  480
tgctatgtt  atgagaaaa  gccaagata  catagaacc  gttcccggt  aaaagggga  540
aaaaaaagc  gtggagcag  gtgacttca  tggagtgga  agcacagga  agaggctgc  600
cttcatggc  aatgaagca  acttggatg  agagctggt  attaaggga  ccatcctac  660
gaagcatcc  agaatacgt  tccacacgg  tcttgtgga  gcccacctc  actgtttga  720
aaaatacat  gtggatttc  taatggaaa  tgggtcaat  acttctatc  ggagtgaac  780
gattccata  ttagtgaga  aacagtttt  ctcagcttc  tcacaacag  gacaagaag  840
aaaagagga  gatctaaag  aaaaggagc  gaagtcctt  gatatctac  gttttataa  900
agaagccaa  acactgaac  tggctccct  tgatgcctg  tggaatgcc  gtcgaggag  960
caggtggga  gacttgtcc  gatcacagg  gcgctgcta  gtccacatc  tgaaagagg  1020
gctctgctc  cgagtgagc  cactgggac  ctacatgga  gcaaacaga  aggtgccca  1080
attgctgtc  gctctctgt  cagaagaac  accagtcca  tcgtcagcc  agattgtca  1140
caaacacct  gttggagtt  acagcctca  tgggccaga  acacagatt  gagagaagt  1200
atccattaa  cgctcagtc  ttggctcat  ctgtctcat  aaagataga  tgactatta  1260
caattgcct  ctcatgaac  cagtcactg  ggaggaagg  taaacgagt  aatgaggtg  1320
tcgtgggga  tgaccagct  atggagatc  gagttctga  caagtcaga  tccttcctt  1380
tggcctcca  agccacaga  gttggccgg  ccacctgtt  aactctgta  ttatttccc  1440
ataaagaag  gcttccaaa  gcatgctgg  gacttgtgg  gcagtccaa  gctccatgt  1500
aggtgggct  caggtgtac  cagtgtatg  tcatgtgtc  tgtggtaaa  atcatctgg  1560
gcaaaaaaa  aaaaaaaaaa  1580



<210> 8530
<211> 452
<212> PRT
<213> Homo sapiens
<308> Q9NR50
<400> 8530

Met Glu Phe Gln Ala Val Val Met Ala Val Gly Gly Gly Ser Arg Met 
  1               5                  10                  15
Thr Asp Leu Thr Ser Ser Ile Pro Lys Pro Leu Leu Pro Val Gly Asn 
             20                  25                  30
Lys Pro Leu Ile Trp Tyr Pro Leu Asn Leu Leu Glu Arg Val Gly Phe 
         35                  40                  45
Glu Glu Val Ile Val Val Thr Thr Arg Asp Val Gln Lys Ala Leu Cys 
     50                  55                  60
Ala Glu Phe Lys Met Lys Met Lys Pro Asp Ile Val Cys Ile Pro Asp 
 65                  70                  75                  80
Asp Ala Asp Met Gly Thr Ala Asp Ser Leu Arg Tyr Ile Tyr Pro Lys 
                 85                  90                  95
Leu Lys Thr Asp Val Leu Val Leu Ser Cys Asp Leu Ile Thr Asp Val 
             100                105                110
Ala Leu His Glu Val Val Asp Leu Phe Arg Ala Tyr Asp Ala Ser Leu 
         115                120                125
Ala Met Leu Met Arg Lys Gly Gln Asp Ser Ile Glu Pro Val Pro Gly 
     130                135                140
Gln Lys Gly Lys Lys Lys Ala Val Glu Gln Arg Asp Phe Ile Gly Val 
 145                150                155                160
Asp Ser Thr Gly Lys Arg Leu Leu Phe Met Ala Asn Glu Ala Asp Leu 
                 165                170                175
Asp Glu Glu Leu Val Ile Lys Gly Ser Ile Leu Gln Lys His Pro Arg 
             180                185                190
Ile Arg Phe His Thr Gly Leu Val Asp Ala His Leu Tyr Cys Leu Lys 
         195                200                205
Lys Tyr Ile Val Asp Phe Leu Met Glu Asn Gly Ser Ile Thr Ser Ile 
     210                215                220
Arg Ser Glu Leu Ile Pro Tyr Leu Val Arg Lys Gln Phe Ser Ser Ala 
 225                230                235                240
Ser Ser Gln Gln Gly Gln Glu Glu Lys Glu Glu Asp Leu Lys Lys Lys 
                 245                250                255
Glu Leu Lys Ser Leu Asp Ile Tyr Ser Phe Ile Lys Glu Ala Asn Thr 
             260                265                270
Leu Asn Leu Ala Pro Tyr Asp Ala Cys Trp Asn Ala Cys Arg Gly Asp 
         275                280                285
Arg Trp Glu Asp Leu Ser Arg Ser Gln Val Arg Cys Tyr Val His Ile 
     290                295                300
Met Lys Glu Gly Leu Cys Ser Arg Val Ser Thr Leu Gly Leu Tyr Met 
 305                310                315                320
Glu Ala Asn Arg Gln Val Pro Lys Leu Leu Ser Ala Leu Cys Pro Glu 
                 325                330                335
Glu Pro Pro Val His Ser Ser Ala Gln Ile Val Ser Lys His Leu Val 
             340                345                350
Gly Val Asp Ser Leu Ile Gly Pro Glu Thr Gln Ile Gly Glu Lys Ser 
         355                360                365
Ser Ile Lys Arg Ser Val Ile Gly Ser Ser Cys Leu Ile Lys Asp Arg 
     370                375                380
Val Thr Ile Thr Asn Cys Leu Leu Met Asn Ser Val Thr Val Glu Glu 
 385                390                395                400
Gly Ser Asn Ile Gln Gly Ser Val Ile Cys Asn Asn Ala Val Ile Glu 
                 405                410                415
Lys Gly Ala Asp Ile Lys Asp Cys Leu Ile Gly Ser Gly Gln Arg Ile 
             420                425                430
Glu Ala Lys Ala Lys Arg Val Asn Glu Val Ile Val Gly Asn Asp Gln 
         435                440                445
Leu Met Glu Ile 
     450



<210> 8531
<211> 2858
<212> DNA
<213> Rattus norvegicus
<308> U38376
<400> 8531

gaattcggc  cgagcggaa  tgtgaaggg  tcccatcag  ctcccgact  acagagagc  60
agaaggcac  gagaaacct  aggattctc  tttaactct  ggaactgct  caagaagct  120
tagtaccag  gaacacctg  gaagtgtga  aattcctgc  gctgggacc  aaatgtctt  180
catagatcc  tatcagcac  taatagtgg  acaccagta  tcccataag  ttacagtag  240
ggttctacg  gccaccaaa  taaccaagg  gacctttgg  gatatgctg  acactcctg  300
tccttatgt  gaacttttc  tctctacaa  ccctgacag  aggaagcga  caagacact  360
caataatga  ataaaccct  tgtggaatg  gacctttga  ttcattttg  atcctaatc  420
ggaaaatgt  ttggagatc  cattgatgg  tgccaatta  gtcatggat  aaaccctag  480
cacagctac  tttcctgta  cttctatga  ggtgggaga  aagaaagaa  tccctttta  540
tttcaacca  gtcacagaa  tgattctgg  aatgtctct  gaagtttcg  catgcccag  600
cctacggtt  agcatggca  tgtgtgatc  ggagaaaac  ttcaggcag  agaggaaag  660
gaacataaa  gagaacatg  agaaacttt  gggtccaaa  aagagcgag  ggctttatt  720
cacacgtga  gtgcctgtg  tggccattt  gggttccgg  gggggtttc  gggccatgg  780
gggattctc  ggtgtgatg  aggcgctct  tgaatcagg  attttggat  gtgcgacct  840
cgttgctgg  ctgtccggc  ccacatggt  catgtcaac  ttgtactcc  accctgatt  900
tccagagaa  ggtcctgag  agattaatg  agagctaat  aaaaatgtt  gccacaacc  960
tctcttact  cttacgcca  agaaagtta  aagatatgt  gagtcttta  ggaagaaga  1020
aagttctgg  cttcctgtc  cctttactg  catctttgg  atgttaata  gagaaacac  1080
aattcaaaa  agaatagta  cgaccttga  tagcttgaa  gaaaaggtc  gcgccgccc  1140
gtgtcctct  cctctcttc  cctgtctcc  tgtcaaacc  gacgtgtca  agctgatgt  1200
tgccgattg  gtagaattt  gtccatacg  aattggcat  gcaaaatat  gtaccttta  1260
gactcctga  ctgtttgga  gcaaatttt  tatgggaac  gttgtaaaa  aatatgaag  1320
aaacccctt  catttctta  tgggtgtct  gggcagtgc  ttttctata  tgttcaaca  1380
agttttggg  gtttctggc  tacagaata  aggttctac  atggaggag  aattagaaa  1440
tattacagc  aagcacatt  tgagtaacg  cagctctga  agcgatgac  aggcccaag  1500
acccaaagg  accgagaat  aagatgcgg  aagagagta  caaaatgac  accaagcaa  1560
ttgggtcca  cggatgcta  tggccttgg  gagtgactc  gctttattc  atacccgag  1620
aggacgtgc  gggaaggtg  ataacttca  gttgggctt  aatctcaac  catcgtatc  1680
actgtctcc  ctgagagac  tcagccccc  agattcctt  gatgatgat  aactcgacg  1740
agcggtagc  gatccagat  aatttgaac  aatatatga  ccactggat  tcaaaagta  1800
aaagattca  gttgtagac  gtgggctca  gtttaacct  ccgtatccc  tgattctgc  1860
acctcagag  ggtgtggat  tcatcattt  ctttgactt  tctgcaagg  caagtgaca  1920
cagccctcc  ttcaaggaa  ttctgcttg  agagaagtg  gctaaaatg  acaagctcc  1980
ttttccaaa  attgatcct  acgtgtttg  tcgggaagg  ttgaaggaa  gctatgtgt  2040
taaacctaa  aatcctgat  tggagaagg  ttgcacaac  attatccac  ttgttctgg  2100
caacatcaa  ttcagaaag  acaaggccc  aggtgttct  agggaaacc  aggaagaga  2160
agaaatagc  gactttgac  ttttcgatg  ccccgaatc  ccattttca  ccttcaact  2220
ccagtatcc  aatcaagca  tcaaaaggc  acatgatct  atgtacttc  acacactga  2280
caacattga  gtgataaag  atgccattg  tgagagcat  gaatacaga  gacagaacc  2340
atctcgttg  tctgtttcc  tcagtaatg  tgaggcaag  aaattcttc  acaaggagt  2400
cctaagtaa  cccacagca  agtccattt  aattccatg  ctactggag  tcagagcac  2460
tgagagatc  tcttactat  cacaagaga  tgactgcta  tcagagttg  ggggacgga  2520
gcgtgtgtt  ggtgaaaac  gtgttgatt  tgcaatact  ggcaacagt  tctgacagt  2580
tgaattttt  gacataagc  tagggctat  tactgtatt  taaacattc  tcacatttt  2640
acctgagca  ttttatata  atataaaaa  atcctttcc  tttataaat  ttaatagtt  2700
aactcagta  aaaaaagct  cccattgtg  gtgaatgtt  ttctgaact  gatttgttc  2760
tgccatgtt  caacactat  tttatttaa  tgttcatat  tacacatgc  aaataaata  2820
tttgatata  aaattgcca  aaaaaaaaa  aaaaaaaa  2858



<210> 8532
<211> 752
<212> PRT
<213> Rattus norvegicus
<308> P50393
<400> 8532

Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr 
  1               5                  10                  15
Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys 
             20                  25                  30
Gly Thr Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu 
         35                  40                  45
Phe Ile Ser Thr Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn 
     50                  55                  60
Asn Asp Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp 
 65                  70                  75                  80
Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr 
                 85                  90                  95
Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Pro Val Ser Ser Met 
             100                105                110
Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Thr 
         115                120                125
Glu Met Ile Leu Glu Met Ser Leu Glu Val Cys Ser Cys Pro Asp Leu 
     130                135                140
Arg Phe Ser Met Ala Leu Cys Asp Gln Glu Lys Thr Phe Arg Arg Gln 
 145                150                155                160
Arg Lys Glu Asn Ile Lys Glu Asn Met Lys Lys Leu Leu Gly Pro Lys 
                 165                170                175
Lys Ser Glu Gly Leu Tyr Ser Thr Arg Asp Val Pro Val Val Ala Ile 
             180                185                190
Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly Phe Ser Gly Val 
         195                200                205
Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys Ala Thr Tyr Val 
     210                215                220
Ala Gly Leu Ser Gly Ser Thr Trp Tyr Met Ser Thr Leu Tyr Ser His 
 225                230                235                240
Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn Glu Glu Leu Met 
                 245                250                255
Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr Pro Gln Lys Val 
             260                265                270
Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser Ser Gly Gln Pro 
         275                280                285
Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly Glu Thr Leu Ile 
     290                295                300
Gln Asn Arg Met Ser Thr Thr Leu Ser Ser Leu Lys Glu Lys Val Ser 
 305                310                315                320
Ala Ala Arg Cys Pro Leu Pro Leu Phe Thr Cys Leu His Val Lys Pro 
                 325                330                335
Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu Phe Ser Pro Tyr 
             340                345                350
Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Thr Pro Asp Leu Phe 
         355                360                365
Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys Tyr Glu Glu Asn 
     370                375                380
Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala Phe Ser Ile Leu 
 385                390                395                400
Phe Asn Arg Val Leu Gly Val Ser Gly Ser Gln Asn Lys Gly Ser Thr 
                 405                410                415
Met Glu Glu Glu Leu Glu Asn Ile Thr Ala Lys His Ile Val Ser Asn 
             420                425                430
Asp Ser Ser Asp Ser Asp Asp Glu Ala Gln Gly Pro Lys Gly Thr Glu 
         435                440                445
Asn Glu Asp Ala Glu Arg Glu Tyr Gln Asn Asp Asn Gln Ala Ser Trp 
     450                455                460
Val His Arg Met Leu Met Ala Leu Val Ser Asp Ser Ala Leu Phe Asn 
 465                470                475                480
Thr Arg Glu Gly Arg Ala Gly Lys Glu His Asn Phe Met Leu Gly Leu 
                 485                490                495
Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Arg Asp Phe Ser Pro 
             500                505                510
Gln Asp Ser Phe Asp Asp Asp Glu Leu Asp Ala Ala Val Ala Asp Pro 
         515                520                525
Asp Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val Lys Ser Lys Lys 
     530                535                540
Ile His Val Val Asp Ser Gly Leu Thr Phe Asn Leu Pro Tyr Pro Leu 
 545                550                555                560
Ile Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile Ser Phe Asp Phe 
                 565                570                575
Ser Ala Arg Pro Ser Asp Thr Ser Pro Pro Phe Lys Glu Leu Leu Leu 
             580                585                590
Ala Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe Pro Lys Ile Asp 
         595                600                605
Pro Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys Tyr Val Phe Lys 
     610                615                620
Pro Lys Asn Pro Asp Val Glu Lys Asp Cys Pro Thr Ile Ile His Phe 
 625                630                635                640
Val Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala Pro Gly Val Leu 
                 645                650                655
Arg Glu Thr Lys Glu Glu Lys Glu Ile Ala Asp Phe Asp Ile Phe Asp 
             660                665                670
Asp Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln Tyr Pro Asn Gln 
         675                680                685
Ala Phe Lys Arg Leu His Asp Leu Met Tyr Phe Asn Thr Leu Asn Asn 
     690                695                700
Ile Asp Val Ile Lys Asp Ala Ile Val Glu Ser Ile Glu Tyr Arg Arg 
 705                710                715                720
Gln Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn Val Glu Ala Arg 
                 725                730                735
Lys Phe Phe Asn Lys Glu Phe Leu Ser Lys Pro Thr Ala Glu Ser Ile 
             740                745                750



<210> 8533
<211> 2875
<212> DNA
<213> Homo sapiens
<308> M68874
<400> 8533

gaattctcc  gagctgaaa  aggatcctg  ctgaaagct  gaggcattg  ggagcctga  60
gattctcag  ttttaaaga  gctagagtg  caaagaaga  tttgaagtg  gaaaacatt  120
cctgtaatt  aaaccaaaa  gtcatttat  gatccttac  agcacatta  agtggagca  180
cagtattcc  acaagttta  ggtagtggt  ttacgtgcc  ccaaagtga  aaagggggc  240
tttggtgac  tgcttgata  tccagatcc  tatgtggaa  tttttatct  tacaacccc  300
gacagcagg  agagaacaa  acatttcaa  aatgacata  accctgtgt  gaatgagac  360
tttgaattt  ttttggatc  taatcagga  aatgttttg  agattacgt  aatggatgc  420
aattatgtc  tggatgaaa  tctagggac  gcaacattt  ctgtatctt  tatgaaggt  480
ggagaaaag  aagaagttc  ttttatttt  aaccaagtc  ctgaaatgg  tctagaaat  540
tctcttgaa  tttgctcat  cccagacct  cgatttagt  tggctctgt  tgatcagga  600
aagactttc  gacaacaga  aaaagaaca  ataagggag  gcatgaaga  actcttggg  660
ccaaagaat  gtgaaggat  gcattctgc  cgtgatgtg  ctgtggtag  catattggg  720
tcaggtggg  gtttccgag  catggtggg  ttctctggt  tgatgaagg  attatacga  780
tcaggaatt  tggattgtg  tacctacgt  gctggtctt  ctggctcca  ctggtatat  840
tcaaccttg  attctcacc  tgattttcc  gagaaaggg  cagaggaga  taatgaaga  900
ctaatgaaa  atgttagcc  caatcccct  ttacttctc  caccacaga  agttaaaag  960
tatgttgag  ctttatgga  gaagaaaag  tctggacaa  ctgtcacct  tactgacat  1020
tttgggatg  taataggag  aacactaat  cataataga  tgaatacta  tctgagcag  1080
ttgaaggaa  aagttaata  tgcacaatg  cctttacct  ttttcacct  tcttcatgt  1140
aaacctgac  tttcagagc  gatgtttgc  gattgggtt  aatttagtc  atacgaaat  1200
ggcatggct  aatatggta  ttttatggc  cccgactta  ttggaagca  attttttat  1260
ggaacagtc  ttaagaagt  tgaagaaaa  cccttgcat  tcttaatgg  tgtctgggg  1320
agtgccttt  ccatattgt  caacagagt  ttgggcgtt  ctggttcac  aagcagagg  1380
tccacaatg  aggaagaat  agaaaatat  accacaaag  atattgtga  taatgatag  1440
tcggacagt  atgatgaat  acacgaacc  aaaggcact  aaaatgaag  tgctggaag  1500
gactatcaa  gtgataatc  agcaagttg  attcatcgt  tgataatgg  cttggtgag  1560
gattcagct  tattcaata  cagagaagg  cgtgctggg  aggtacaca  cttcatgct  1620
ggcttgaat  tcaatacat  ttatccact  tctcctttg  gtgactttg  cacacagga  1680
tcctttgat  atgatgaac  ggatgcagc  gtagcagat  ctgatgaat  tgagcgaat  1740
tatgagcct  tggatgtca  aagtaaaaa  attcatgta  tggacagtg  gctcacatt  1800
aacctgccg  atcccttga  actgagacc  cagagaggg  ttgatctca  aatctcctt  1860
gacttttct  caaggccaa  tgactctag  cctccgttc  aggaacttc  acttgcaga  1920
aagtgggct  aaatgaaca  gctcccctt  ccaaagatt  atccttatg  gtttgatcg  1980
gaagggctg  aggagtgct  tgtctttaa  cccaagaat  ctgatatgg  gaaagattg  2040
ccaaccatc  tccactttg  tctggccaa  atcaacttc  gaaagtaca  ggctccagg  2100
gttccaagg  aaactgagg  agagaaaga  atcgctgac  ttgatattt  tgatgaccc  2160
gaatcacca  tttcaacct  caattttca  tatccaaat  aagcattca  aagactaca  2220
gatcttatg  acttcaata  tctgaacaa  attgatgtg  taaaagaag  catggttga  2280
agcattgaa  atagaagac  gaatccatc  cgttgctct  tttccctta  taatgttga  2340
gcaagaaga  ttttcaaca  ggagtttct  agtaaaccc  aagcatagt  catgtactg  2400
aaatggcag  agtttctga  gctgaggca  tttgcaatc  catgacaac  ggatttaaa  2460
gtacagtac  gatagtcgt  ctgatcatg  gagactggc  gatactcaa  gttgcagtt  2520
cttagctgc  tgagaataa  actattata  gttaggtga  aaatgatgt  gattatgta  2580
ggatatact  agctacatt  tcagtcagt  tgaacttcc  gatacaaat  tagggatat  2640
tactgtatt  ttaaacatt  ctcaccaac  ttcttatgt  tgttctttt  aaaaatttt  2700
tttctttta  aatatttaa  agttcaatc  caataagac  tcgcattat  tatgaatgt  2760
attcactga  tagatttat  cataccatg  gacaacact  tttttattt  tatatgcat  2820
tatatacat  catgaaata  atacatcaa  ataaaaata  aaaaaaacg  aattc  2875



<210> 8534
<211> 749
<212> PRT
<213> Homo sapiens
<308> P47712
<400> 8534

Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr 
  1               5                  10                  15
Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys 
             20                  25                  30
Gly Ala Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu 
         35                  40                  45
Phe Ile Ser Thr Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn 
     50                  55                  60
Asn Asp Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp 
 65                  70                  75                  80
Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr 
                 85                  90                  95
Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Thr Val Ser Ser Met 
             100                105                110
Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Thr 
         115                120                125
Glu Met Val Leu Glu Met Ser Leu Glu Val Cys Ser Cys Pro Asp Leu 
     130                135                140
Arg Phe Ser Met Ala Leu Cys Asp Gln Glu Lys Thr Phe Arg Gln Gln 
 145                150                155                160
Arg Lys Glu His Ile Arg Glu Ser Met Lys Lys Leu Leu Gly Pro Lys 
                 165                170                175
Asn Ser Glu Gly Leu His Ser Ala Arg Asp Val Pro Val Val Ala Ile 
             180                185                190
Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly Phe Ser Gly Val 
         195                200                205
Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys Ala Thr Tyr Val 
     210                215                220
Ala Gly Leu Ser Gly Ser Thr Trp Tyr Met Ser Thr Leu Tyr Ser His 
 225                230                235                240
Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn Glu Glu Leu Met 
                 245                250                255
Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr Pro Gln Lys Val 
             260                265                270
Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser Ser Gly Gln Pro 
         275                280                285
Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly Glu Thr Leu Ile 
     290                295                300
His Asn Arg Met Asn Thr Thr Leu Ser Ser Leu Lys Glu Lys Val Asn 
 305                310                315                320
Thr Ala Gln Cys Pro Leu Pro Leu Phe Thr Cys Leu His Val Lys Pro 
                 325                330                335
Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu Phe Ser Pro Tyr 
             340                345                350
Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Ala Pro Asp Leu Phe 
         355                360                365
Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys Tyr Glu Glu Asn 
     370                375                380
Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala Phe Ser Ile Leu 
 385                390                395                400
Phe Asn Arg Val Leu Gly Val Ser Gly Ser Gln Ser Arg Gly Ser Thr 
                 405                410                415
Met Glu Glu Glu Leu Glu Asn Ile Thr Thr Lys His Ile Val Ser Asn 
             420                425                430
Asp Ser Ser Asp Ser Asp Asp Glu Ser His Glu Pro Lys Gly Thr Glu 
         435                440                445
Asn Glu Asp Ala Gly Ser Asp Tyr Gln Ser Asp Asn Gln Ala Ser Trp 
     450                455                460
Ile His Arg Met Ile Met Ala Leu Val Ser Asp Ser Ala Leu Phe Asn 
 465                470                475                480
Thr Arg Glu Gly Arg Ala Gly Lys Val His Asn Phe Met Leu Gly Leu 
                 485                490                495
Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Ser Asp Phe Ala Thr 
             500                505                510
Gln Asp Ser Phe Asp Asp Asp Glu Leu Asp Ala Ala Val Ala Asp Pro 
         515                520                525
Asp Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val Lys Ser Lys Lys 
     530                535                540
Ile His Val Val Asp Ser Gly Leu Thr Phe Asn Leu Pro Tyr Pro Leu 
 545                550                555                560
Ile Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile Ser Phe Asp Phe 
                 565                570                575
Ser Ala Arg Pro Ser Asp Ser Ser Pro Pro Phe Lys Glu Leu Leu Leu 
             580                585                590
Ala Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe Pro Lys Ile Asp 
         595                600                605
Pro Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys Tyr Val Phe Lys 
     610                615                620
Pro Lys Asn Pro Asp Met Glu Lys Asp Cys Pro Thr Ile Ile His Phe 
 625                630                635                640
Val Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala Pro Gly Val Pro 
                 645                650                655
Arg Glu Thr Glu Glu Glu Lys Glu Ile Ala Asp Phe Asp Ile Phe Asp 
             660                665                670
Asp Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln Tyr Pro Asn Gln 
         675                680                685
Ala Phe Lys Arg Leu His Asp Leu Met His Phe Asn Thr Leu Asn Asn 
     690                695                700
Ile Asp Val Ile Lys Glu Ala Met Val Glu Ser Ile Glu Tyr Arg Arg 
 705                710                715                720
Gln Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn Val Glu Ala Arg 
                 725                730                735
Arg Phe Phe Asn Lys Glu Phe Leu Ser Lys Pro Lys Ala 
             740                745



<210> 8535
<211> 3298
<212> DNA
<213> Rattus norvegicus
<308> U38801
<400> 8535

cggcaccat  agcaaacgc  aggccccgc  ggagaccct  aacggcggc  tcacggaca  60
gctcgtgga  ctcgcaaac  ttgagaaga  cgtgagcca  gcgatccac  agtacaatg  120
atacagaaa  gcagcatct  tgatagcaa  gtacccaca  aaaatcaag  gtggagcag  180
agctaagaa  ttgccagga  taggaacaa  aattgctga  aagattgat  aatttttag  240
aactggaaa  ttgcgtaaa  tggaaaaga  tcgtcagga  gatacaagt  catccatca  300
cttcctgac  cgagttact  gcatcgggc  atctgctgc  aggaagctt  tagatgaag  360
aattaaaac  ttagaagat  tcaggaaaa  tgaagataa  ttgaaccac  atcagcgaa  420
tgggctgaa  tattttgag  actttgaaa  gagaattcc  cgtgaggag  tgctgcaaa  480
gcaggacat  gttcttaat  aagttaaaa  gctggatcc  gagtacatc  ctacagtct  540
cggcagttt  cgaagaggc  cagagtcca  tggagatat  gacgttctg  tgacccacc  600
aaacttcac  tcagaatca  gcaaacagc  aaagttgtt  catcgtgtt  tggaacagt  660
acaaaaagt  cgtttcatt  cagatactc  ttcaaaggg  gagacaaag  tcatgggtg  720
ttgccagct  cccagcgag  atgatgaaa  cgaatatcc  cacaggaga  tcgatatca  780
gttgatccc  aaagatcag  actactgtg  tgttctcta  ttcactgga  gtgacatct  840
taataagaa  atgagagcg  atgccctgg  aaagggctt  acaatcaat  agtacacca  900
ccgccccct  ggggtcact  gggttgctg  ggagcccct  ccggtggac  gcgagcagg  960
cattttcga  tacatccag  ggcgctacc  ggagcccaa  gacaggagt  aatgacgcc  1020
gccccaccc  ggcctatcc  acgaggagt  ctaagttat  gcttaacct  tgctatgta  1080
gggttgggt  ttttaggtg  ttgcctctt  tctgtgctt  ccatggact  tcgtcaatg  1140
acctcttga  cagctattc  gtattttct  agcacatgt  tttaaactt  gatatgttt  1200
tgatcgcag  accatggtt  actagagaa  cgtaagagc  gatgtgata  gcagtgttt  1260
atgaccttt  acttccacc  cacattgca  ccacagtcg  ccccacttg  ccctatcca  1320
cctttatgg  tcagctggt  tcccagagc  atctccaga  gtcacttca  tatccttag  1380
aacaagggg  ttccaggca  ggtggtgca  atccttaat  ccaggactt  ggaggcaga  1440
acaggcaga  ctctgtgag  tcaaggcca  cccagacta  atactgaat  cagggtgcc  1500
gagctacat  gtgaggccc  atctaaaaa  aaaggggcc  tcatagctg  aagacttct  1560
tgaccattt  ccatttgca  tgtatactg  taactagaa  acagtgtgt  ctttacctc  1620
ggggcagcc  tcccctcac  gctcaatgg  acctaacta  cattcatca  tcgtctggt  1680
gacagtcca  tgtttatca  ataacattc  gtgacacga  caaagaact  caagtttaa  1740
aaagattta  ttgagcaga  tgagccact  tgtctggat  gctttattg  agagtcctg  1800
catgttgta  atggtagtc  caaagtcag  agtaactca  cacagcgtc  ggtcactgt  1860
agttgctag  agattcagc  ttatttatg  gctgggtat  atgtacttg  ctgtaatcc  1920
aagactcac  cgaggcaag  ggaacatga  ttcgaagcc  accctgggc  atatagctt  1980
ctctgagac  ctgtctcag  acccttacc  ctcccccca  aaattatcc  ggaggcaga  2040
gcaggtggg  ctctatgag  gtaaggcca  ccagggcta  acagcgaga  cactgtctc  2100
gaaaacaaa  taaaaaata  aataaaatt  gtgccaggg  ttctgtgtg  acacgaggg  2160
caagtccca  gtctgtaca  cttatattc  ttggcatac  cttagcctt  tatgttgtc  2220
gttaccagt  acctgactt  gacaggaca  tccagggac  acagtcaca  cgctggaag  2280
tttctgggg  ttgggcagt  tctttgtgc  ccctcctgg  acacacttg  ccctctagt  2340
gaactggct  gcaaatttt  gtccaaaaa  ggcgagcac  gcaaagtcc  gggccgcag  2400
cggaggttc  gagacagct  tctccctcc  gtcctgtaa  aaggtaggc  caggctcta  2460
aggtggcag  tgggttaag  gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  2520
gttatacta  tgggttgag  ttgggatct  ggaatgaag  cctatatag  ctatatata  2580
actagcaaa  ccaacagga  acaggtctc  cagaataag  gaaattaga  ccctactga  2640
caaagacat  aaggaatga  tatctaccc  gagaaatag  tagcactcc  caaagtttg  2700
taatacagt  tttcgtgag  atcgattcc  ttacttata  aggggccag  tagtccaat  2760
tgtgagtag  agcggctgt  gtacctctc  actttcaaa  actctgtta  tcaagactt  2820
aactcgaga  tcctatttt  gtttaaaag  atttttgta  atccccaag  gtggtggca  2880
acaccttta  tcccagcag  agccgtcgg  tctctgagt  cctgaacag  ctggtctac  2940
cagtgagtt  taggatagc  gagctacag  cccttttgt  ctatgtaca  gtctggagt  3000
aatgcatct  ctttaatcc  ctctgtatg  tgaggctat  ggaaaggta  gtggcactt  3060
gtacacccc  gcttaggga  agccatcgg  tggaggttt  cttcctaag  tgtcatcac  3120
agggtcttg  cctggcctg  ccaatagag  cccttgaat  gctccaaga  ctcacagac  3180
tgaggtaaa  gagtttagc  tcagcctgt  gggctggga  ggagaaaat  gtttttaaa  3240
taaaatatg  tctccttaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  3298



<210> 8536
<211> 334
<212> PRT
<213> Rattus norvegicus
<308> P06766
<400> 8536

Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr Asp 
  1               5                  10                  15
Met Leu Val Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala Ile 
             20                  25                  30
His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys Tyr 
         35                  40                  45
Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly Val 
     50                  55                  60
Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly Lys 
 65                  70                  75                  80
Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser Ile 
                 85                  90                  95
Asn Phe Leu Thr Arg Val Thr Gly Ile Gly Pro Ser Ala Ala Arg Lys 
             100                105                110
Leu Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn Glu 
         115                120                125
Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys Tyr Phe Glu Asp 
     130                135                140
Phe Glu Lys Arg Ile Pro Arg Glu Glu Met Leu Gln Met Gln Asp Ile 
 145                150                155                160
Val Leu Asn Glu Val Lys Lys Leu Asp Pro Glu Tyr Ile Ala Thr Val 
                 165                170                175
Cys Gly Ser Phe Arg Arg Gly Ala Glu Ser Ser Gly Asp Met Asp Val 
             180                185                190
Leu Leu Thr His Pro Asn Phe Thr Ser Glu Ser Ser Lys Gln Pro Lys 
         195                200                205
Leu Leu His Arg Val Val Glu Gln Leu Gln Lys Val Arg Phe Ile Thr 
     210                215                220
Asp Thr Leu Ser Lys Gly Glu Thr Lys Phe Met Gly Val Cys Gln Leu 
 225                230                235                240
Pro Ser Glu Asn Asp Glu Asn Glu Tyr Pro His Arg Arg Ile Asp Ile 
                 245                250                255
Arg Leu Ile Pro Lys Asp Gln Tyr Tyr Cys Gly Val Leu Tyr Phe Thr 
             260                265                270
Gly Ser Asp Ile Phe Asn Lys Asn Met Arg Ala His Ala Leu Glu Lys 
         275                280                285
Gly Phe Thr Ile Asn Glu Tyr Thr Ile Arg Pro Leu Gly Val Thr Gly 
     290                295                300
Val Ala Gly Glu Pro Leu Pro Val Asp Ser Glu Gln Asp Ile Phe Asp 
 305                310                315                320
Tyr Ile Gln Trp Arg Tyr Arg Glu Pro Lys Asp Arg Ser Glu 
                 325                330



<210> 8537
<211> 1259
<212> DNA
<213> Homo sapiens
<308> M13140
<400> 8537

ccggagctg  gttgctcct  ctcccgtct  caagtcctg  tacctcctt  aagctggga  60
agggctcta  tccctggtt  tgaacactc  ggggttctc  ggtgcaggc  gccatgagc  120
aacggaagg  gccgcagga  actctcaac  ggggaatca  cgacatgct  acagaactc  180
caaactttg  gaagaacgt  agccaagct  tccacaagt  caatgctta  agaaaagca  240
catctgtta  agcaaaata  ccacacaaa  taaagagtg  agctgaagc  aagaaattg  300
ctggagtag  aacaaaaat  gctgaaaag  ttgatgagt  tttagcaac  ggaaaatta  360
gtaaactgg  aaagattcg  caggatgat  cgagttcat  catcaattt  ctgactcga  420
ttagtggca  tggtccatc  gctgcaagg  agtttgtag  tgaaggaat  aaaacacta  480
aagatctca  aaaaaatga  gataaattg  accatcatc  gcgaattgg  ctgaaatat  540
ttggggact  tgaaaaaag  attcctcgt  aagagatgt  acaaatgca  gatattgtt  600
taaatgaag  taaaaaagt  gattctgaa  acattgcta  agtctgtgg  agtttcaga  660
gaggtgcag  gtccagtgg  gacatggat  ttctcctga  ccatcccag  ttcacttca  720
aatcaacca  acagccaaa  ctgttacat  aggttgtgg  gcagttaca  aaggttcat  780
ttatcacag  tacccgttc  aagggtgag  caaagttca  gggtgtttg  cagcttccc  840
gtaaaaatg  tgaaaaaga  tatccacac  gaagaattg  tatcaggtt  tacccaaaa  900
atcagtatt  ctgtggtgt  ctctatttc  ctgggagtg  tattttcaa  aagaatatg  960
gagctcatg  caaggaaaa  ggtttcaca  tcaatgagt  caccatccg  cccttggga  1020
tcactggag  tgcaggaga  cccctgcca  tggatagtg  aaaagacat  tttgattac  1080
tccagtgga  ataccggga  cccaaggac  ggagcgaat  aggcctgta  cctccctgg  1140
gcagacaca  cccaatggg  cttaattta  ttcttaacc  ttgctatgt  agggtcttt  1200
gtgttttta  atgattgtt  cttcttcat  cttttgctt  caatgtagt  aataaaacc  1259



<210> 8538
<211> 334
<212> PRT
<213> Homo sapiens
<308> P06746
<400> 8538

Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr Asp 
  1               5                  10                  15
Met Leu Thr Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala Ile 
             20                  25                  30
His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys Tyr 
         35                  40                  45
Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly Val 
     50                  55                  60
Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly Lys 
 65                  70                  75                  80
Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser Ile 
                 85                  90                  95
Asn Phe Leu Thr Arg Val Ser Gly Ile Gly Pro Ser Ala Ala Arg Lys 
             100                105                110
Phe Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn Glu 
         115                120                125
Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys Tyr Phe Gly Asp 
     130                135                140
Phe Glu Lys Arg Ile Pro Arg Glu Glu Met Leu Gln Met Gln Asp Ile 
 145                150                155                160
Val Leu Asn Glu Val Lys Lys Val Asp Ser Glu Tyr Ile Ala Thr Val 
                 165                170                175
Cys Gly Ser Phe Arg Arg Gly Ala Glu Ser Ser Gly Asp Met Asp Val 
             180                185                190
Leu Leu Thr His Pro Ser Phe Thr Ser Glu Ser Thr Lys Gln Pro Lys 
         195                200                205
Leu Leu His Gln Val Val Glu Gln Leu Gln Lys Val His Phe Ile Thr 
     210                215                220
Asp Thr Leu Ser Lys Gly Glu Thr Lys Phe Met Gly Val Cys Gln Leu 
 225                230                235                240
Pro Ser Lys Asn Asp Glu Lys Glu Tyr Pro His Arg Arg Ile Asp Ile 
                 245                250                255
Arg Leu Ile Pro Lys Asp Gln Tyr Tyr Cys Gly Val Leu Tyr Phe Thr 
             260                265                270
Gly Ser Asp Ile Phe Asn Lys Asn Met Arg Ala His Ala Leu Glu Lys 
         275                280                285
Gly Phe Thr Ile Asn Glu Tyr Thr Ile Arg Pro Leu Gly Val Thr Gly 
     290                295                300
Val Ala Gly Glu Pro Leu Pro Val Asp Ser Glu Lys Asp Ile Phe Asp 
 305                310                315                320
Tyr Ile Gln Trp Lys Tyr Arg Glu Pro Lys Asp Arg Ser Glu 
                 325                330



<210> 8539
<211> 2538
<212> DNA
<213> Rattus norvegicus
<308> U39044
<400> 8539

gagggacgt  cccggaaag  taccggtca  aagaaacta  ctccacatc  ccacctgac  60
ggtcacaac  atgtcagac  aaagtgaat  aaaagctga  ttggaacgt  agaagcaac  120
gttggccca  atcagagaa  aaaagaaga  gaaagaaga  gaaaggaaa  aaaaagaaa  180
tgatcagaa  aaggaagct  cagtctctg  gcaggaaga  tctgacctt  aaaagaaga  240
aagagaagc  gaagccttg  ttcagagca  ggggctaac  acagactcc  caattgttt  300
ttctgagca  tgggtccct  ctcccatgt  tccatcctc  aagtcggtg  gcacgccaa  360
tgaagctgg  agccaggac  ctggagatg  cgccgtggg  tctaggacg  tgcactggg  420
tacagatcc  tcagctctt  agctccact  agattccga  ttgggacga  gacctatta  480
acttggaat  gccaaaatt  ctcaagtcg  ctttccccc  cgagaaatc  tcacatata  540
aaaggaaac  cagaccccg  ttacagctc  acccaaaga  gatgaggag  aggaagatg  600
cgtagcagc  cctaagcct  ctgttgaac  tgaagaaga  aaaatttta  aaaaagacg  660
agagaatga  agcaaagct  cccctcatg  actaactga  gaagaaaag  aacaaattt  720
acactcaga  gaattttta  gtttctttg  ccattctac  agaattgta  aaagagccc  780
ctctgagca  attaacatc  tctttgact  cagtgggag  gatttggaa  acaaagaag  840
ggagattca  gcaggtgct  agctgtcat  aaatcgaca  ttttttgat  agcgttggt  900
aaagcatcg  gttgttagt  gcttggatt  gtcatccca  tatccagaa  tacttgtgg  960
ttcctataa  aacaatgaa  aggctcctc  tgagcctga  ggtgtggcc  tcgtatgga  1020
tatgaagta  aagaaaact  ccccagagt  cgtgttcca  tgccagtca  ctgtaatgt  1080
tgctacatt  gcaaaattt  atccaaatc  tgttgttgg  ggtacatac  caggccaaa  1140
tgtgctttg  gataaccgt  gcaataaaa  aacccccgt  cagagaaca  cactgtcag  1200
tgctgcaca  acacaccct  tctactgtg  aaatgttgt  ggaacacaa  atgctcata  1260
tctgattag  atctctact  atggaaaaa  ttgctcctg  agcttagac  tgctttccc  1320
tccacagga  agcatggag  tggttcata  acagtcaaa  gcagtagct  taacatcta  1380
gtctttccc  gttggagac  tcaacaact  tgttgtggg  agtgaagaa  gttctgtgt  1440
tacagcatg  cgccatggc  gcaaagccg  aatcagtga  atgtttgag  gacaccagg  1500
acccatcac  ggaatccac  gtcacgcag  tgttggcgc  gtagacttc  cacatctgt  1560
cgtcacttc  tcttttgac  ggacagtaa  actttggtc  actaagaat  acaagcctt  1620
gtactcatt  gaagataat  cagactatg  ctatgatgt  attgggtca  ccacccacc  1680
agccctgtt  gcctgtgtg  atggcatgg  gagactgga  ctatggaat  tcaacaatg  1740
cacagaggt  ccgactgcc  gcatttctg  ggagggcaa  cctgccctt  accgtgtga  1800
atggaccca  tcgggaaga  agatcgccg  gggtgattc  gaaggacag  ttgtcatat  1860
tgatgtggg  gagcagatc  ctgttcccc  aaatgatga  tgggcaaga  ttggccgaa  1920
actcgcaga  attaacgca  gccgagctg  tgcagagga  gaagcggct  cccggattc  1980
tgcctaggc  tggagggtg  ccgtagcct  atcgagtct  gcaaagagg  tgaagtaga  2040
cctaaacta  tttgcatgc  tctgattaa  cgagaatta  aagaaaact  catggatag  2100
ctgggttta  tacaggaag  aaagcttac  gaagccctt  tatattcta  tccctttgc  2160
ttggattgg  gtcattttt  atacagctg  caactttac  gaatgcagc  ttttctgaa  2220
tctaacaca  ggggtgtat  ttgttaatt  ttcttttgg  ttcttttga  cttgtacta  2280
tatatataa  tatttctaa  gcacagact  agtgagttc  gcatatttc  aaagagcca  2340
gagtccctt  ttaatgcaa  acagtacat  ggtccttgt  agttaatgt  ctcactgcc  2400
tgagtgagt  ggaacattg  tcttagtgc  agcatcgat  cgcctacct  ttttaagtt  2460
catgttgat  ccgttttcc  tctctatag  tcatggatg  tatctataa  taaaaacaa  2520
tatgtgcta  cttaaaaa  2538



<210> 8540
<211> 638
<212> PRT
<213> Rattus norvegicus
<308> Q62871
<400> 8540

Met Ser Asp Lys Ser Glu Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
  1               5                  10                  15
Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
             20                  25                  30
Lys Lys Lys Glu Thr Asp Gln Lys Lys Glu Ala Ala Val Ser Val Gln 
         35                  40                  45
Glu Glu Ser Asp Leu Glu Lys Lys Arg Arg Glu Ala Glu Ala Leu Leu 
     50                  55                  60
Gln Ser Met Gly Leu Thr Thr Asp Ser Pro Ile Val Phe Ser Glu His 
 65                  70                  75                  80
Trp Val Pro Pro Pro Met Ser Pro Ser Ser Lys Ser Val Ser Thr Pro 
                 85                  90                  95
Ser Glu Ala Gly Ser Gln Asp Ser Gly Asp Gly Ala Val Gly Ser Arg 
             100                105                110
Thr Leu His Trp Asp Thr Asp Pro Ser Ala Leu Gln Leu His Ser Asp 
         115                120                125
Ser Asp Leu Gly Arg Gly Pro Ile Lys Leu Gly Met Ala Lys Ile Thr 
     130                135                140
Gln Val Asp Phe Pro Pro Arg Glu Ile Val Thr Tyr Thr Lys Glu Thr 
 145                150                155                160
Gln Thr Pro Val Thr Ala Gln Pro Lys Glu Asp Glu Glu Glu Glu Asp 
                 165                170                175
Asp Val Ala Ala Pro Lys Pro Pro Val Glu Pro Glu Glu Glu Lys Ile 
             180                185                190
Leu Lys Lys Asp Glu Glu Asn Asp Ser Lys Ala Pro Pro His Glu Leu 
         195                200                205
Thr Glu Glu Glu Lys Gln Gln Ile Leu His Ser Glu Glu Phe Leu Ser 
     210                215                220
Phe Phe Asp His Ser Thr Arg Ile Val Glu Arg Ala Leu Ser Glu Gln 
 225                230                235                240
Ile Asn Ile Phe Phe Asp Tyr Ser Gly Arg Asp Leu Glu Asp Lys Glu 
                 245                250                255
Gly Glu Ile Gln Ala Gly Ala Lys Leu Ser Leu Asn Arg Gln Phe Phe 
             260                265                270
Asp Glu Arg Trp Ser Lys His Arg Val Val Ser Cys Leu Asp Trp Ser 
         275                280                285
Ser Gln Tyr Pro Glu Leu Leu Val Ala Ser Tyr Asn Asn Asn Glu Glu 
     290                295                300
Ala Pro His Glu Pro Asp Gly Val Ala Leu Val Trp Asn Met Lys Tyr 
 305                310                315                320
Lys Lys Thr Thr Pro Glu Tyr Val Phe His Cys Gln Ser Ala Val Met 
                 325                330                335
Ser Ala Thr Phe Ala Lys Phe His Pro Asn Leu Val Val Gly Gly Thr 
             340                345                350
Tyr Ser Gly Gln Ile Val Leu Trp Asp Asn Arg Ser Asn Lys Arg Thr 
         355                360                365
Pro Val Gln Arg Thr Pro Leu Ser Ala Ala Ala His Thr His Pro Val 
     370                375                380
Tyr Cys Val Asn Val Val Gly Thr Gln Asn Ala His Asn Leu Ile Ser 
 385                390                395                400
Ile Ser Thr Asp Gly Lys Ile Cys Ser Trp Ser Leu Asp Met Leu Ser 
                 405                410                415
His Pro Gln Asp Ser Met Glu Leu Val His Lys Gln Ser Lys Ala Val 
             420                425                430
Ala Val Thr Ser Met Ser Phe Pro Val Gly Asp Val Asn Asn Phe Val 
         435                440                445
Val Gly Ser Glu Glu Gly Ser Val Tyr Thr Ala Cys Arg His Gly Ser 
     450                455                460
Lys Ala Gly Ile Ser Glu Met Phe Glu Gly His Gln Gly Pro Ile Thr 
 465                470                475                480
Gly Ile His Cys His Ala Ala Val Gly Ala Val Asp Phe Ser His Leu 
                 485                490                495
Phe Val Thr Ser Ser Phe Asp Trp Thr Val Lys Leu Trp Ser Thr Lys 
             500                505                510
Asn Asn Lys Pro Leu Tyr Ser Phe Glu Asp Asn Ser Asp Tyr Val Tyr 
         515                520                525
Asp Val Ile Gly Ser Pro Thr His Pro Ala Leu Phe Ala Cys Val Asp 
     530                535                540
Gly Met Gly Arg Leu Asp Leu Trp Asn Leu Asn Asn Asp Thr Glu Val 
 545                550                555                560
Pro Thr Ala Ser Ile Ser Val Glu Gly Asn Pro Ala Leu Asn Arg Val 
                 565                570                575
Arg Trp Thr His Ser Gly Arg Glu Ile Ala Val Gly Asp Ser Glu Gly 
             580                585                590
Gln Ile Val Ile Tyr Asp Val Gly Glu Gln Ile Ala Val Pro Arg Asn 
         595                600                605
Asp Glu Trp Ala Arg Phe Gly Arg Thr Leu Ala Glu Ile Asn Ala Ser 
     610                615                620
Arg Ala Asp Ala Glu Glu Glu Ala Ala Thr Arg Ile Pro Ala 
 625                630                635



<210> 8541
<211> 2497
<212> DNA
<213> Homo sapiens
<308> AF250307
<400> 8541

gggaaagcc  cggagctgg  ggtggctac  gttggtgtt  ggggcttag  cgagggacg  60
taccgggaa  ttgcaggcg  gaggactct  ccccatcca  tcacctgac  ggtcacaaa  120
atgtcagac  aaagtgaat  aaaggctga  ttggaacgt  agaagcagc  actggccca  180
atcagagag  aaaagaaga  aaaagaaga  gaaaggaaa  aaaaagaaa  agaccagaa  240
aaggaagct  ttgctcctg  gcaagaaga  tcagatctt  aaaaaaaaa  gagagaagc  300
gaagcattg  ttcaaagca  ggggctaac  ccagaatcc  ccattgtcc  tcctcctat  360
tctccatcc  ccaaatctg  gagcactcc  agtgaagct  gaagccaag  ctctggaga  420
ggcgccgtg  gatctagac  aggacctat  aaacttgga  tggctaaaa  cacgcaagt  480
gactttcct  ctcgagaaa  tgtcacgta  acaaaggaa  ctcagactc  agttatggc  540
caacccaaa  aagatgaag  ggaagatga  gatgtagtg  ctcctaaac  acctattga  600
cctgaagaa  agaaaactt  aaagaaaga  gaggaaaat  atagtaaag  tccccctca  660
gagctgact  aagaagaaa  gcaacaaat  ttgcactct  aggaatttt  aagtttctt  720
gaccattct  caagaattg  agaaagagc  ctttctgag  agattaaca  cttctttga  780
tatagtggg  gagatttgg  agacaaaga  ggagagatt  aagcaggtg  taaactgtc  840
ttaaatcga  aattttttg  cgaacgttg  tcaaagcat  gggtggtta  ttgtttgga  900
tggtcatct  agtatccgg  gttactcgt  gcttcctat  acaacaatg  agatgcccc  960
catgagcct  atggtgtgg  ccttgtatg  aatatgaaa  acaaaaaaa  taccccaga  1020
tatgtgttt  actgccagt  agctgtgat  tctgccaca  ttgcaaaat  tcatccaaa  1080
cttgttgtt  gtggtacat  ttcaggcca  attgtgctt  gggataacc  tagcaataa  1140
agaactcca  tgcaaagaa  tccactgtc  gcagctgca  acacacacc  tgtatattg  1200
gtaaatgtt  ttggaacac  aaatgctca  aatctgatt  gcatctcta  tgatggaaa  1260
atttgttca  ggagtctgg  catgctttc  catccacag  atagcatgg  gttggttca  1320
aaacagtca  aagcagtag  tgtgacatc  atgtccttc  ctgttggag  tgtcaacaa  1380
tttgttgtt  ggagtgaag  aggttctgt  tacacagca  gccgccatg  cagcaaagc  1440
ggaatcagt  agatgtttg  ggggcatca  ggaccaatc  ctggcatcc  ttgtcatgc  1500
gctgttgga  cagtagact  ctcacatct  tttgtcact  catcgtttg  ctggacagt  1560
aagctttgg  caactaaga  taacaagcc  ttgtattca  ttgaagata  tgcagacta  1620
gtttatgat  ttatgtggt  acctaccca  ccagccctg  ttgcctgtg  ggatggcat  1680
gggagattg  atttgtgga  tctcaataa  gacacagag  taccaactg  cagcatttc  1740
gtggagggt  atcctgctc  taatcgtgt  agatggacc  attctggca  agagattgc  1800
gtgggtgat  ctgaaggac  gattgttat  tacgatgtg  gagagcaga  tgctgttcc  1860
cgcaatgat  aatgggcac  gtttggccg  acacttgca  aaattaatg  aaaccgagc  1920
gatgcagag  aggaagcag  tacccgaat  cctgcttag  tcctgaaaa  gggagtgta  1980
ctagtggat  tgggaaagg  tcttaagta  atcctgaga  tatttgcat  cttctgtct  2040
aatgataat  aaaaggaaa  ttcatggat  aacccatgg  tttaatgca  caaggaaac  2100
tacaatgtc  ctttatata  aacatgcat  ttgttttgg  tttgtgtca  tttttaata  2160
agctgattg  cttcacaga  agcagcttt  ttgaattct  atacatagg  gtatatttg  2220
tattagtta  tttgagttc  tttcaactt  taacactgt  tacagttat  tctaaagca  2280
agatgaaat  agttctgca  atttttaaa  aatcacagt  ccctgttat  cagataatg  2340
tctcactac  cataatatg  aggaacatt  tttctcctt  gccgtagta  gcatacacc  2400
atccatgtt  attctgaca  cctttgttg  ctttataat  catgtggta  ttacctata  2460
ataaaaaca  atatgcgtt  aaaaaaaaa  aaaaaaa  2497



<210> 8542
<211> 573
<212> PRT
<213> Homo sapiens
<308> Q13409
<400> 8542

Gln Pro Leu Arg Val Val Thr Ala Asp Thr Cys Leu Phe His Tyr Leu 
  1               5                  10                  15
Val Pro Pro Pro Met Ser Pro Ser Ser Lys Ser Val Ser Thr Pro Ser 
             20                  25                  30
Glu Ala Gly Ser Gln Asp Ser Gly Asp Gly Ala Val Gly Ser Arg Thr 
         35                  40                  45
Leu His Trp Asp Thr Asp Pro Ser Val Leu Gln Leu His Ser Asp Ser 
     50                  55                  60
Asp Leu Gly Arg Gly Pro Ile Lys Leu Gly Met Ala Lys Ile Thr Gln 
 65                  70                  75                  80
Val Asp Phe Pro Pro Arg Glu Ile Val Thr Tyr Thr Lys Glu Thr Gln 
                 85                  90                  95
Thr Pro Val Met Ala Gln Pro Lys Glu Asp Glu Glu Glu Asp Asp Asp 
             100                105                110
Val Val Ala Pro Lys Pro Pro Ile Glu Pro Glu Glu Glu Lys Thr Leu 
         115                120                125
Lys Lys Asp Glu Glu Asn Asp Ser Lys Ala Pro Pro His Glu Leu Thr 
     130                135                140
Glu Glu Glu Lys Gln Gln Ile Leu His Ser Glu Glu Phe Leu Ser Phe 
 145                150                155                160
Phe Asp His Ser Thr Arg Ile Val Glu Arg Ala Leu Ser Glu Gln Ile 
                 165                170                175
Asn Ile Phe Phe Asp Tyr Ser Gly Arg Asp Leu Glu Asp Lys Glu Gly 
             180                185                190
Glu Ile Gln Ala Gly Ala Lys Leu Ser Leu Asn Arg Gln Phe Phe Asp 
         195                200                205
Glu Arg Trp Ser Lys His Arg Val Val Ser Cys Leu Asp Trp Ser Ser 
     210                215                220
Gln Tyr Pro Glu Leu Leu Val Ala Ser Tyr Asn Asn Asn Glu Asp Ala 
 225                230                235                240
Pro His Glu Pro Asp Gly Val Ala Leu Val Trp Asn Met Lys Tyr Lys 
                 245                250                255
Lys Thr Thr Pro Glu Tyr Val Phe His Cys Gln Ser Ala Val Met Ser 
             260                265                270
Ala Thr Phe Ala Lys Phe His Pro Asn Leu Val Val Gly Gly Thr Tyr 
         275                280                285
Ser Gly Gln Ile Val Leu Trp Asp Asn Arg Ser Asn Lys Arg Thr Pro 
     290                295                300
Val Gln Arg Thr Pro Leu Ser Ala Ala Ala His Thr His Pro Val Tyr 
 305                310                315                320
Cys Val Asn Val Val Gly Thr Gln Asn Ala His Asn Leu Ile Ser Ile 
                 325                330                335
Ser Thr Asp Gly Lys Ile Cys Ser Trp Ser Leu Asp Met Leu Ser His 
             340                345                350
Pro Gln Asp Ser Met Glu Leu Val His Lys Gln Ser Lys Ala Val Ala 
         355                360                365
Val Thr Ser Met Ser Phe Pro Val Gly Asp Val Asn Asn Phe Val Val 
     370                375                380
Gly Ser Glu Glu Gly Ser Val Tyr Thr Ala Cys Arg His Gly Ser Lys 
 385                390                395                400
Ala Gly Ile Ser Glu Met Phe Glu Gly His Gln Gly Pro Ile Thr Gly 
                 405                410                415
Ile His Cys His Ala Ala Val Gly Ala Val Asp Phe Ser His Leu Phe 
             420                425                430
Val Thr Ser Ser Phe Asp Trp Thr Val Lys Leu Trp Thr Thr Lys Asn 
         435                440                445
Asn Lys Pro Leu Tyr Ser Phe Glu Asp Asn Ala Asp Tyr Val Tyr Asp 
     450                455                460
Val Met Trp Ser Pro Thr His Pro Ala Leu Phe Ala Cys Val Asp Gly 
 465                470                475                480
Met Gly Arg Leu Asp Leu Trp Asn Leu Asn Asn Asp Thr Glu Val Pro 
                 485                490                495
Thr Ala Ser Ile Ser Val Glu Gly Asn Pro Ala Leu Asn Arg Val Arg 
             500                505                510
Trp Thr His Ser Gly Arg Glu Ile Ala Val Gly Asp Ser Glu Gly Gln 
         515                520                525
Ile Val Ile Tyr Asp Val Gly Glu Gln Ile Ala Val Pro Arg Asn Asp 
     530                535                540
Glu Trp Ala Arg Phe Gly Arg Thr Leu Ala Glu Ile Asn Ala Asn Arg 
 545                550                555                560
Ala Asp Ala Glu Glu Glu Ala Ala Thr Arg Ile Pro Ala 
                 565                570



<210> 8543
<211> 678
<212> DNA
<213> Rattus norvegicus
<308> U39572
<400> 8543

gcctgcagg  cgactctag  gacagacac  acggtaaca  tatgctgga  aagaaggga  60
acatcatcc  catagactt  ggcttcatg  ttgaaagct  accgggtgg  aaccttggc  120
gggagccag  catcaagct  acagacgag  tggtgatga  tatgggggg  aagatggaa  180
ccacaccct  caagtggtt  atggagatg  gcgtccgag  ttatctggc  gtgcgcccc  240
atatggatg  agtcgtctc  ctggttaca  tcatgttgg  cacaggcct  ccctgtttc  300
gtggccaga  aatcaaact  ttgaaacac  ggttcagcc  gaacatgac  gagcgggag  360
ctgcaaatt  tatcatgaa  atcatccaa  actgtttcc  cagcaacag  agccggacc  420
acgacatga  ccagtacta  cagaatgat  tcccctact  aggagactg  acctgaagc  480
ttgagtgtc  cagagcagc  tgtactgtc  ccataagcc  gggtgtgga  gtgacaggc  540
catggaact  ggatgcaca  gtgtgagtc  ttttcacac  ggatacact  cctatttgt  600
cacccatct  actatgttg  tacatgaag  attttcctg  gtaaacatg  gaaattgac  660
taaaaaata  gaacccta  678



<210> 8544
<211> 2041
<212> PRT
<213> Rattus norvegicus
<308> AAD10400
<400> 8544

Met Cys Pro Val Asp Phe His Gly Ile Phe Gln Leu Asp Glu Arg Arg 
  1               5                  10                  15
Arg Asp Ala Val Ile Ala Leu Gly Ile Phe Leu Ile Glu Ser Asp Leu 
             20                  25                  30
Gln His Lys Asp Cys Ile Val Pro Tyr Leu Leu Arg Leu Leu Arg Gly 
         35                  40                  45
Leu Pro Lys Val Tyr Trp Val Glu Glu Ser Thr Ala Arg Lys Gly Arg 
     50                  55                  60
Gly Asn Leu Pro Val Ala Glu Ser Phe Ser Phe Cys Leu Val Thr Leu 
 65                  70                  75                  80
Leu Ser Asp Val Ala Cys Arg Asp Pro Ser Leu Arg Asp Glu Ile Leu 
                 85                  90                  95
Glu Ala Leu Leu Gln Val Leu His Val Leu Leu Gly Met Cys Gln Ala 
             100                105                110
Leu Glu Ile Gln Glu Lys Glu Tyr Leu Cys Lys Tyr Ala Ile Pro Cys 
         115                120                125
Leu Ile Gly Ile Ser Lys Ser Phe Gly Arg Tyr Ser Asn Ser Glu Glu 
     130                135                140
Ser Leu Leu Ser Lys Leu Phe Pro Lys Val Pro Pro His Ser Leu Arg 
 145                150                155                160
Ile Pro Glu Glu Leu Glu Gly Val Arg Arg Arg Ser Phe Asn Asp Phe 
                 165                170                175
Arg Ser Ile Leu Pro Ser Asn Leu Leu Thr Val Cys Gln Glu Gly Thr 
             180                185                190
Leu Lys Arg Lys Thr Ser Ser Val Ser Ser Ile Ser Gln Val Ser Pro 
         195                200                205
Glu Arg Gly Met Pro Pro Pro Ser Ser Pro Gly Gly Ser Ala Phe His 
     210                215                220
Tyr Phe Glu Ala Ser Cys Leu Pro Asp Gly Thr Thr Leu Glu Pro Glu 
 225                230                235                240
Tyr Tyr Phe Ser Thr Ile Ser Ser Ser Phe Ser Val Ser Pro Leu Phe 
                 245                250                255
Asn Gly Ile Thr Tyr Lys Glu Phe Tyr Ile Pro Leu Glu Met Leu Arg 
             260                265                270
Glu Leu Leu Asn Leu Val Lys Lys Ile Val Glu Glu Pro Val Leu Lys 
         275                280                285
Ser Leu Asp Ala Ala Val Ala Arg Val Met Glu Ala Asn Pro Ser Ala 
     290                295                300
Asp Leu Tyr Tyr Thr Thr Phe Ser Asp Pro Val Tyr Leu Thr Met Phe 
 305                310                315                320
Lys Met Leu Arg Asp Thr Leu Tyr Tyr Met Lys Asp Leu Pro Thr Ser 
                 325                330                335
Phe Val Lys Glu Ile His Asp Phe Val Leu Glu Gln Phe Asn Met Ser 
             340                345                350
Gln Gly Glu Leu Gln Lys Ile Leu His Asp Ala Asp Arg Ile His Ser 
         355                360                365
Glu Met Ser Pro Leu Lys Leu Arg Cys Gln Ala Asn Ala Ala Cys Val 
     370                375                380
Asp Leu Met Val Trp Ala Val Lys Asp Glu Gln Gly Ala Glu Asn Leu 
 385                390                395                400
Cys Ile Lys Leu Ser Glu Lys Leu Gln Ser Lys Thr Ser Ser Lys Val 
                 405                410                415
Ile Ile Ala His Leu Pro Leu Leu Ile Cys Cys Leu Gln Gly Leu Gly 
             420                425                430
Arg Leu Cys Glu Arg Phe Pro Val Val Val His Ser Val Thr Pro Ser 
         435                440                445
Leu Arg Asp Phe Leu Val Ile Pro Ser Pro Val Leu Val Lys Leu Tyr 
     450                455                460
Lys Tyr His Ser Gln Tyr His Thr Val Ala Gly Ser Asp Ile Lys Ile 
 465                470                475                480
Ser Val Thr Asn Glu His Ser Glu Ser Thr Leu Asn Val Leu Pro Gly 
                 485                490                495
Lys Lys Asn Gln Pro Ser Met Tyr Glu Gln Leu Arg Asp Ile Ala Ile 
             500                505                510
Asp Asn Ile Cys Arg Cys Leu Lys Ala Gly Leu Thr Val Asp Pro Val 
         515                520                525
Ile Val Glu Ala Phe Leu Ala Ser Leu Ser Asn Arg Leu Tyr Ile Ser 
     530                535                540
Gln Glu Ser Asp Lys Asp Ala His Leu Ile Pro Asp His Thr Ile Arg 
 545                550                555                560
Ala Leu Gly His Ile Ala Val Ala Leu Arg Asp Thr Pro Lys Val Met 
                 565                570                575
Glu Pro Ile Leu Gln Gln Lys Phe Cys Gln Pro Pro Ser Pro Leu Asp 
             580                585                590
Val Leu Ile Ile Asp Gln Leu Gly Cys Leu Val Ile Thr Gly Asn Gln 
         595                600                605
Tyr Ile Tyr Gln Glu Val Trp Asn Leu Phe Gln Gln Ile Ser Val Lys 
     610                615                620
Ala Ser Ser Val Val Tyr Ser Ala Thr Lys Asp Tyr Lys Asp His Gly 
 625                630                635                640
Tyr Arg His Cys Ser Leu Ala Val Ile Asn Ala Leu Ala Asn Ile Ala 
                 645                650                655
Ala Asn Ile Gln Glu Glu His Leu Val Asp Glu Leu Leu Met Asn Leu 
             660                665                670
Leu Glu Leu Phe Val Gln Leu Gly Leu Glu Gly Lys Arg Ala Ser Glu 
         675                680                685
Arg Ala Ser Glu Lys Gly Pro Ala Leu Lys Ala Ser Ser Ser Ala Gly 
     690                695                700
Asn Leu Gly Val Leu Ile Pro Val Ile Ala Val Leu Thr Arg Arg Leu 
 705                710                715                720
Pro Pro Ile Lys Glu Ala Lys Pro Arg Leu Gln Lys Leu Phe Arg Asp 
                 725                730                735
Phe Trp Leu Tyr Ser Val Leu Met Gly Phe Ala Val Glu Gly Ser Gly 
             740                745                750
Leu Trp Pro Glu Glu Trp Tyr Glu Gly Val Cys Glu Ile Ala Thr Lys 
         755                760                765
Ser Pro Leu Leu Thr Phe Pro Ser Lys Glu Pro Leu Arg Ser Val Leu 
     770                775                780
Gln Tyr Asn Ser Ala Met Lys Asn Asp Thr Val Thr Pro Ala Glu Leu 
 785                790                795                800
Asn Glu Leu Arg Ser Thr Ile Ile Asn Leu Leu Asp Pro Pro Pro Glu 
                 805                810                815
Val Ser Ala Leu Ile Asn Lys Leu Asp Phe Ala Met Ser Thr Tyr Leu 
             820                825                830
Leu Ser Val Tyr Arg Leu Glu Tyr Met Arg Val Leu Arg Ser Thr Asp 
         835                840                845
Pro Asp Arg Phe Gln Val Met Phe Cys Tyr Phe Glu Asp Lys Ala Ile 
     850                855                860
Gln Lys Asp Lys Ser Gly Met Met Gln Cys Val Ile Ala Val Ala Asp 
 865                870                875                880
Lys Val Phe Asp Ala Phe Leu Asn Met Met Ala Glu Lys Ala Lys Thr 
                 885                890                895
Lys Glu Asn Glu Glu Glu Leu Glu Arg His Ala Gln Phe Leu Leu Val 
             900                905                910
Asn Phe Asn His Ile His Lys Arg Ile Arg Arg Val Ala Asp Lys Tyr 
         915                920                925
Leu Ser Gly Leu Val Asp Lys Phe Pro His Leu Leu Trp Ser Gly Thr 
     930                935                940
Val Leu Lys Thr Met Leu Asp Ile Leu Gln Thr Leu Ser Leu Ser Leu 
 945                950                955                960
Ser Ala Asp Ile His Lys Asp Gln Pro Tyr Tyr Asp Ile Pro Asp Ala 
                 965                970                975
Pro Tyr Arg Ile Thr Val Pro Asp Thr Tyr Glu Ala Arg Glu Ser Ile 
             980                985                990
Val Lys Asp Phe Ala Ala Arg Cys Gly Met Ile Leu Gln Glu Ala Met 
         995                1000                1005
Lys Trp Ala Pro Thr Val Thr Lys Ser His Leu Gln Glu Tyr Leu Asn 
     1010                1015                1020
Lys His Gln Asn Trp Val Ser Gly Leu Ser Gln His Thr Gly Leu Ala 
 1025                1030                1035                1040
Met Ala Thr Glu Ser Ile Leu His Phe Ala Gly Tyr Asn Lys Gln Asn 
                 1045                1050                1055
Thr Thr Leu Gly Val Thr Gln Leu Thr Glu Arg Pro Ala Cys Val Lys 
             1060                1065                1070
Lys Asp Tyr Ser Asn Phe Met Ala Ser Leu Asn Leu Arg Asn Arg Tyr 
         1075                1080                1085
Ala Gly Glu Val His Gly Met Ile Arg Phe Ser Gly Ala Thr Gly Gln 
     1090                1095                1100
Met Ser Asp Leu Asn Lys Met Met Val Gln Asp Leu Ile Thr Ala Leu 
 1105                1110                1115                1120
Asp His Ser His Pro Gln His Tyr Thr Gln Ala Met Phe Lys Leu Thr 
                 1125                1130                1135
Ala Met Leu Ile Ser Ser Lys Asp Cys Asp Pro Gln Leu Leu His His 
             1140                1145                1150
Leu Cys Trp Gly Pro Leu Arg Met Phe Asn Glu His Gly Met Glu Thr 
         1155                1160                1165
Ala Leu Ala Cys Trp Glu Trp Leu Leu Ala Gly Lys Asn Gly Val Glu 
     1170                1175                1180
Val Pro Phe Met Arg Glu Met Ala Gly Ala Trp His Met Thr Val Glu 
 1185                1190                1195                1200
Gln Lys Phe Gly Leu Phe Ser Ala Glu Thr Lys Glu Ala Asp Pro Leu 
                 1205                1210                1215
Ala Ala Ser Glu Ala Ser Gln Pro Arg Pro Cys Pro Pro Glu Val Thr 
             1220                1225                1230
Pro His Tyr Ile Trp Ile Asp Phe Leu Val Gln Arg Phe Glu Ile Ala 
         1235                1240                1245
Lys Tyr Cys Ser Ser Asp Gln Val Glu Ile Phe Ser Ser Leu Leu Gln 
     1250                1255                1260
Arg Ser Met Ser Leu His Ile Gly Gly Ala Arg Gly Ser Met Asn Arg 
 1265                1270                1275                1280
His Val Ala Ala Ile Gly Pro Arg Phe Lys Leu Leu Thr Leu Gly Leu 
                 1285                1290                1295
Ser Leu Leu His Ala Asp Val Val Pro Asn Ala Thr Ile Arg Asn Val 
             1300                1305                1310
Leu Arg Glu Lys Ile Tyr Ser Thr Ala Phe Asp Tyr Phe Ser Cys Pro 
         1315                1320                1325
Pro Lys Phe Pro Thr Gln Gly Glu Lys Arg Leu Arg Glu Asp Ile Ser 
     1330                1335                1340
Ile Met Ile Lys Phe Trp Thr Ala Met Phe Ser Asp Lys Lys Tyr Leu 
 1345                1350                1355                1360
Thr Ala Ser Gln Leu Val Pro Pro Asp Asn Gln Asp Thr Arg Ser Asn 
                 1365                1370                1375
Leu Asp Ile Thr Val Gly Ser Arg Gln Gln Ala Thr Gln Gly Trp Ile 
             1380                1385                1390
Asn Thr Tyr Pro Leu Ser Ser Gly Met Ser Thr Ile Ser Lys Lys Ser 
         1395                1400                1405
Gly Met Ser Lys Lys Thr Asn Arg Gly Ser Gln Leu His Lys Tyr Tyr 
     1410                1415                1420
Met Lys Arg Arg Thr Leu Leu Leu Ser Leu Leu Ala Thr Glu Ile Glu 
 1425                1430                1435                1440
Arg Leu Ile Thr Trp Tyr Asn Pro Leu Ser Ala Pro Glu Leu Glu Leu 
                 1445                1450                1455
Asp Gln Ala Gly Glu Asn Ser Val Ala Asn Trp Arg Ser Lys Tyr Ile 
             1460                1465                1470
Ser Leu Ser Glu Lys Gln Trp Lys Asp Asn Val Asn Leu Ala Trp Thr 
         1475                1480                1485
Ile Ser Pro Tyr Leu Ala Val Gln Leu Pro Ala Arg Phe Lys Asn Thr 
     1490                1495                1500
Glu Ala Ile Gly Asn Glu Val Thr Arg Leu Val Arg Leu Asp Pro Gly 
 1505                1510                1515                1520
Ala Val Ser Asp Val Pro Glu Ala Ile Lys Phe Leu Val Thr Trp His 
                 1525                1530                1535
Thr Ile Asp Ala Asp Ala Pro Glu Leu Ser His Val Leu Cys Trp Ala 
             1540                1545                1550
Pro Thr Asp Pro Pro Thr Gly Leu Ser Tyr Phe Ser Ser Met Tyr Pro 
         1555                1560                1565
Pro His Pro Leu Thr Ala Gln Tyr Gly Val Lys Val Leu Arg Ser Phe 
     1570                1575                1580
Pro Pro Asp Ala Ile Leu Phe Tyr Ile Pro Gln Ile Val Gln Ala Leu 
 1585                1590                1595                1600
Arg Tyr Asp Lys Met Gly Tyr Val Arg Glu Tyr Ile Leu Trp Ala Ala 
                 1605                1610                1615
Ala Lys Ser Gln Leu Leu Ala His Gln Phe Ile Trp Asn Met Lys Thr 
             1620                1625                1630
Asn Ile Tyr Leu Asp Glu Glu Gly His Gln Lys Asp Pro Asp Ile Gly 
         1635                1640                1645
Asp Leu Leu Glu Gln Leu Val Glu Glu Ile Thr Gly Ser Leu Ser Gly 
     1650                1655                1660
Pro Ala Lys Asp Phe Tyr Gln Arg Glu Phe Asp Phe Phe Asn Lys Ile 
 1665                1670                1675                1680
Thr Asn Val Ser Ala Ile Ile Lys Pro Tyr Pro Lys Gly Asp Glu Arg 
                 1685                1690                1695
Lys Lys Ala Cys Leu Ser Ala Leu Ser Glu Val Lys Val Gln Pro Gly 
             1700                1705                1710
Cys Tyr Leu Pro Ser Asn Pro Glu Ala Ile Val Leu Asp Ile Asp Tyr 
         1715                1720                1725
Lys Ser Gly Thr Pro Met Gln Ser Ala Ala Lys Ala Pro Tyr Leu Ala 
     1730                1735                1740
Lys Phe Lys Val Lys Arg Cys Gly Val Ser Glu Leu Glu Lys Glu Gly 
 1745                1750                1755                1760
Leu Gln Cys Arg Ser Asp Thr Glu Asp Glu Cys Arg Arg Gln Glu Ala 
                 1765                1770                1775
Asp Gly Lys Lys Ile Cys Trp Gln Ala Ala Ile Phe Lys Val Gly Asp 
             1780                1785                1790
Asp Cys Arg Gln Asp Met Leu Ala Leu Gln Ile Ile Asp Leu Phe Lys 
         1795                1800                1805
Asn Ile Phe Gln Leu Val Gly Leu Asp Leu Phe Val Phe Pro Tyr Arg 
     1810                1815                1820
Val Val Ala Thr Ala Pro Gly Cys Gly Val Ile Glu Cys Ile Pro Asp 
 1825                1830                1835                1840
Cys Thr Ser Arg Asp Gln Leu Gly Arg Gln Thr Asp Phe Gly Met Tyr 
                 1845                1850                1855
Asp Tyr Phe Thr Arg Gln Tyr Gly Asp Glu Ser Thr Leu Ala Phe Gln 
             1860                1865                1870
Gln Ala Arg Tyr Asn Phe Ile Arg Ser Met Ala Ala Tyr Ser Leu Leu 
         1875                1880                1885
Leu Phe Leu Leu Gln Ile Lys Asp Arg His Asn Gly Asn Ile Met Leu 
     1890                1895                1900
Asp Lys Lys Gly His Ile Ile His Ile Asp Phe Gly Phe Met Phe Glu 
 1905                1910                1915                1920
Ser Ser Pro Gly Gly Asn Leu Gly Trp Glu Pro Asp Ile Lys Leu Thr 
                 1925                1930                1935
Asp Glu Met Val Met Ile Met Gly Gly Lys Met Glu Ala Thr Pro Phe 
             1940                1945                1950
Lys Trp Phe Met Glu Met Cys Val Arg Gly Tyr Leu Ala Val Arg Pro 
         1955                1960                1965
Tyr Met Asp Ala Val Val Ser Leu Val Thr Leu Met Leu Asp Thr Gly 
     1970                1975                1980
Leu Pro Cys Phe Arg Gly Gln Thr Ile Lys Leu Leu Lys His Arg Phe 
 1985                1990                1995                2000
Ser Pro Asn Met Thr Glu Arg Glu Ala Ala Asn Phe Ile Met Lys Ile 
                 2005                2010                2015
Ile Gln Asn Cys Phe Leu Ser Asn Arg Ser Arg Thr Tyr Asp Met Ile 
             2020                2025                2030
Gln Tyr Tyr Gln Asn Asp Ile Pro Tyr 
         2035                2040



<210> 8545
<211> 1787
<212> DNA
<213> Homo sapiens
<308> AK024034
<400> 8545

aaaaaatta  ctgggcatg  tggtgggca  ctgtagtcc  agctactcg  gaggctgag  60
caggagaat  tcttgaacc  aggaggcag  ggttgcagt  agccaagat  atgccactg  120
actccagcc  ggcgacaga  cgagactcc  tttaaaaaa  aaaacacca  ggcatctgt  180
agccacttt  ggagtcaaa  gaatgtaga  ctgggctgg  ctccttaga  gaaagttaa  240
ttctgagtg  gggaggaag  gcctgcacc  ccacatcca  acagcccgt  actcctgct  300
ccgaagact  acttgctga  tcgggctct  cctccatag  gggggcaca  agccaggga  360
agtgcccac  ggcccaggg  tcctgggtg  gggaccagg  agaatgccc  caggcccca  420
ggccttttt  agcccaggg  gctctctgc  caggcctgc  acaacttca  ccgaagcat  480
gccgcctac  gcctcctgc  gttcctgct  cagatcaag  acagacaca  cggcaacat  540
atgctggac  agaagggcc  tatcatcca  atcggtcag  cagccacag  gccaccctc  600
tctcccttc  ccccggcac  caggggtgg  tagggatcc  caccccaca  agaggagaa  660
gcccaggac  accctgcca  gagtgtcag  gtccagctc  gaggtccga  ctgtcggcc  720
ccaagctgt  ctgctgtag  gggtgcctg  ccccggccc  agggagctg  ggcgagagc  780
gccattgct  tgagtcaga  gctggagct  ggcggagtg  ggctcgtcc  ggttcagtg  840
cccagcttg  ctccttcct  cacttcctc  cttctcttt  tctgcctgc  gccccacca  900
ccaccccat  actgtctcc  agaaaacac  acctgcctt  tgggggtgg  gggggtgct  960
ctgttgcag  gtccttttc  actcctcaa  acagaccac  cgtccttgc  cgccctggc  1020
cctacccag  cacaggcag  tctttggtg  tttgcagac  ttggcttca  gtttgaaag  1080
tcgccgggc  gcaatctcg  ctgggaacc  gacatcaag  tgacggatg  gatggtgat  1140
atcatgggg  gcaagatgg  ggccacacc  ttcaagtgg  tcatggaga  gtgtgtcca  1200
gctacctgg  tgtgcggcc  tacatggat  tggtcgtct  cctggtcac  atcatgttg  1260
acacgggcc  gccctgttt  cgcggccag  caatcaagt  cttgaagca  aggtttagc  1320
ccaacatga  tgagcgcga  gctgcaaat  tcatcatga  ggtcatcca  agctgcttc  1380
tcagcaaca  gagccggac  tacaacatg  tccagtact  tcagaatga  atcccctac  1440
gaggagggg  ccttcgagg  cctctgccc  atgtgccct  gaagctgcc  cacaatcat  1500
gagccctgc  acctacccg  cctgccgcc  catgcagtg  aggagaggc  tgtggcccg  1560
agagcctgg  agcgcctcc  ggggcagca  gtgggtggc  caggcttag  aacgccgtg  1620
actgcagcg  caatcagtg  atggtgctg  ctatgcaca  gtgtgagtc  tctgtttgc  1680
ctggacata  tccctacct  ttttatttc  taggtacat  aagtattgt  tataaaaaa  1740
gagataaga  ttaaccaac  tcaacaaaa  aaaaaccca  aatagtg  1787



<210> 8546
<211> 854
<212> PRT
<213> Homo sapiens
<308> P42356
<400> 8546

Met Arg Glu Met Ala Gly Ala Trp His Met Thr Val Glu Gln Lys Phe 
  1               5                  10                  15
Gly Leu Phe Ser Ala Glu Ile Lys Glu Ala Asp Pro Leu Ala Ala Ser 
             20                  25                  30
Glu Ala Ser Gln Pro Lys Pro Cys Pro Pro Glu Val Thr Pro His Tyr 
         35                  40                  45
Ile Trp Ile Asp Phe Leu Val Gln Arg Phe Glu Ile Ala Lys Tyr Cys 
     50                  55                  60
Ser Ser Asp Gln Val Glu Ile Phe Ser Ser Leu Leu Gln Arg Ser Met 
 65                  70                  75                  80
Ser Leu Asn Ile Gly Gly Ala Lys Gly Ser Met Asn Arg His Val Ala 
                 85                  90                  95
Ala Ile Gly Pro Arg Phe Lys Leu Leu Thr Leu Gly Leu Ser Leu Leu 
             100                105                110
His Ala Asp Val Val Pro Asn Ala Thr Ile Arg Asn Val Leu Arg Glu 
         115                120                125
Lys Ile Tyr Ser Thr Ala Phe Asp Tyr Phe Ser Cys Pro Pro Lys Phe 
     130                135                140
Pro Thr Gln Gly Glu Lys Arg Leu Arg Glu Asp Ile Ser Ile Met Ile 
 145                150                155                160
Lys Phe Trp Thr Ala Met Phe Ser Asp Lys Lys Tyr Leu Thr Ala Ser 
                 165                170                175
Gln Leu Val Pro Pro Asp Asn Gln Asp Thr Arg Ser Asn Leu Asp Ile 
             180                185                190
Thr Val Gly Ser Arg Gln Gln Ala Thr Gln Gly Trp Ile Asn Thr Tyr 
         195                200                205
Pro Leu Ser Ser Gly Met Ser Thr Ile Ser Lys Lys Ser Gly Met Ser 
     210                215                220
Lys Lys Thr Asn Arg Gly Ser Gln Leu His Lys Tyr Tyr Met Lys Arg 
 225                230                235                240
Arg Thr Leu Leu Leu Ser Leu Leu Ala Thr Glu Ile Glu Arg Leu Ile 
                 245                250                255
Thr Trp Tyr Asn Pro Leu Ser Ala Pro Glu Leu Glu Leu Asp Gln Ala 
             260                265                270
Gly Glu Asn Ser Val Ala Asn Trp Arg Ser Lys Tyr Ile Ser Leu Ser 
         275                280                285
Glu Lys Gln Trp Lys Asp Asn Val Asn Leu Ala Trp Ser Ile Ser Pro 
     290                295                300
Tyr Leu Ala Val Gln Leu Pro Ala Arg Phe Lys Asn Thr Glu Ala Ile 
 305                310                315                320
Gly Asn Glu Val Thr Arg Leu Val Arg Leu Asp Pro Gly Ala Val Ser 
                 325                330                335
Asp Val Pro Glu Ala Ile Lys Phe Leu Val Thr Trp His Thr Ile Asp 
             340                345                350
Ala Asp Ala Pro Glu Leu Ser His Val Leu Cys Trp Ala Pro Thr Asp 
         355                360                365
Pro Pro Thr Gly Leu Ser Tyr Phe Ser Ser Met Tyr Pro Pro His Pro 
     370                375                380
Leu Thr Ala Gln Tyr Gly Val Lys Val Leu Arg Ser Phe Pro Pro Asp 
 385                390                395                400
Ala Ile Leu Phe Tyr Ile Pro Gln Ile Val Gln Ala Leu Arg Tyr Asp 
                 405                410                415
Lys Met Gly Tyr Val Arg Glu Tyr Ile Leu Trp Ala Ala Ser Lys Ser 
             420                425                430
Gln Leu Leu Ala His Gln Phe Ile Trp Asn Met Lys Thr Asn Ile Tyr 
         435                440                445
Leu Asp Glu Glu Gly His Gln Lys Asp Pro Asp Ile Gly Asp Leu Leu 
     450                455                460
Asp Gln Leu Val Glu Glu Ile Thr Gly Ser Leu Ser Gly Pro Ala Lys 
 465                470                475                480
Asp Phe Tyr Gln Arg Glu Phe Asp Phe Phe Asn Lys Ile Thr Asn Val 
                 485                490                495
Ser Ala Ile Ile Lys Pro Tyr Pro Lys Gly Asp Glu Arg Lys Lys Ala 
             500                505                510
Cys Leu Ser Ala Leu Ser Glu Val Lys Val Gln Pro Gly Cys Tyr Leu 
         515                520                525
Pro Ser Asn Pro Glu Ala Ile Val Leu Asp Ile Asp Tyr Lys Ser Gly 
     530                535                540
Thr Pro Met Gln Ser Ala Ala Lys Ala Pro Tyr Leu Ala Lys Phe Lys 
 545                550                555                560
Val Lys Arg Cys Gly Val Ser Glu Leu Glu Lys Glu Gly Leu Arg Cys 
                 565                570                575
Arg Ser Asp Ser Glu Asp Glu Cys Ser Thr Gln Glu Ala Asp Gly Gln 
             580                585                590
Lys Ile Ser Trp Gln Ala Ala Ile Phe Lys Val Gly Asp Asp Cys Arg 
         595                600                605
Gln Asp Met Leu Ala Leu Gln Ile Ile Asp Leu Phe Lys Asn Ile Phe 
     610                615                620
Gln Leu Val Gly Leu Asp Leu Phe Val Phe Pro Tyr Arg Val Val Ala 
 625                630                635                640
Thr Ala Pro Gly Cys Gly Val Ile Glu Cys Ile Pro Asp Cys Thr Ser 
                 645                650                655
Arg Asp Gln Leu Gly Arg Gln Thr Asp Phe Gly Met Tyr Asp Tyr Phe 
             660                665                670
Thr Arg Gln Tyr Gly Asp Glu Ser Thr Leu Ala Phe Gln Gln Ala Arg 
         675                680                685
Tyr Asn Phe Ile Arg Ser Met Ala Ala Tyr Ser Leu Leu Leu Phe Leu 
     690                695                700
Leu Gln Ile Lys Asp Arg His Asn Gly Asn Ile Met Leu Asp Lys Lys 
 705                710                715                720
Gly His Ile Ile His Ile Asp Phe Gly Phe Met Phe Glu Ser Ser Pro 
                 725                730                735
Gly Gly Asn Leu Gly Trp Glu Pro Asp Ile Lys Leu Thr Asp Glu Met 
             740                745                750
Val Met Ile Met Gly Gly Lys Met Glu Ala Thr Pro Phe Lys Trp Phe 
         755                760                765
Met Glu Met Cys Val Arg Gly Tyr Leu Ala Val Arg Pro Tyr Met Asp 
     770                775                780
Ala Val Val Ser Leu Val Thr Leu Met Leu Asp Thr Gly Leu Pro Cys 
 785                790                795                800
Phe Arg Gly Gln Thr Ile Lys Leu Leu Lys His Arg Phe Ser Pro Asn 
                 805                810                815
Met Thr Glu Arg Glu Ala Ala Asn Phe Ile Met Lys Val Ile Gln Ser 
             820                825                830
Cys Phe Leu Ser Asn Arg Ser Arg Thr Tyr Asp Met Ile Gln Tyr Tyr 
         835                840                845
Gln Asn Asp Ile Pro Tyr 
     850



<210> 8547
<211> 3027
<212> DNA
<213> Rattus norvegicus
<308> U41845
<400> 8547

ggcagtagc  ggatgaggg  gttgcttgc  tcctccctt  tttttctcc  attggttct  60
aggggtata  tcgagttgc  aaatggcgg  cccgagcgc  ctcttcagc  ttcagtagc  120
gcttcaggc  gagcggatg  ctcttctcc  cagtttcgg  ctcagagac  cgcggctcc  180
tactcctgc  gatcacgaa  tccttgaag  cgctcaacg  accggaatc  cccagcggc  240
gcgaccgcc  cctcggccc  gctctccgc  gcgccggaa  tcagcgtga  ctgcggcgg  300
cgtctagga  gttcacaaa  atggcgaag  gagttgcgg  gaaggaatt  acagatagg  360
attgggatg  agaagatga  gttgaagag  tgggaacat  ctcagtggc  agtgaggaa  420
tcatgaaga  cagagccgt  aagaaggca  agcgtagga  tattggctt  gaatctgat  480
gcggaggag  ctttaaagg  ttcaaaggg  tggttgtgc  ttctggagg  ggagggttt  540
ctggatttg  tggtggctc  ggagggaag  ctctggaag  actgacaaa  ggaaacagc  600
cagacagtg  cacgccctt  tccagtgca  agacagcag  ggagcctaa  gcagccttt  660
gttcttttg  tgtgaatgg  cctactact  tggtggata  aaagatctc  agtcctaaa  720
gcaatagca  caatcagcc  ccctcctcc  gcccagcct  cagtacctc  tgcactggg  780
atacctatc  taagcagtt  gctggcttg  actgctctg  ccgggattg  atagtgaag  840
atgttaaca  aaacccact  tgtgacctg  cgcccattt  taaagacta  gagagatac  900
tagcgacga  cgagaagca  ctggagaat  ggggtagca  cagctcaga  agacagaca  960
acagggcga  ggctgcaat  gagcctcct  ccctttttg  ttcaacaaa  ctacagcaa  1020
attcaccat  ttcatttca  ggcaacaaa  cggaggaca  atctgaaaa  ttggagttt  1080
cagcagaaa  gaaatcgga  gcagcacaa  gagcaacaa  tgcctcgtt  aattttggc  1140
agaaaattg  gagctcagt  ttgggctct  taagctctg  ctccctaac  gggttttca  1200
tctctcctg  aaactctag  ttatttggt  aagatgctg  ccagagtaa  gcagcctct  1260
caccgtttt  tgctaaagc  tccgagagt  aagcaggag  cagcagcag  gagtgcaga  1320
atggtgaag  agaggagag  gatgagcca  ccaaggtgg  ggtgactga  gtgaaggaa  1380
aggatgctt  ctactccaa  aaatgtaaa  tattttaca  gaaagacaa  gaatttaaa  1440
agaagggtg  ggggaccct  catttaaaa  ccacagcaa  tcagaagac  cagctcttg  1500
tgcgggcag  caccaacct  ggcaacatt  tgctgaatg  tctgatccc  cccaatatg  1560
cgtgcaccc  gacagggaa  aacaatgtc  ttatcgtct  tgtccccaa  cccccactt  1620
atgagaagc  gcccactct  ccggtcacc  tgctgattc  ggtgaagac  agcgaggat  1680
ctgatgagt  gcacaagat  ttactgcag  aaaaggacg  ctgagcact  aggctgacc  1740
gggcacgtc  ccatgttgc  gcttccctt  gcccctaaa  ttagtcaca  tctttcctc  1800
ttgtactgt  acattctga  aacttctag  taacttgaa  cttttgtga  gaagattaa  1860
gccaataaa  cctttcagt  tgtcgaagc  gttctccct  cctaagaac  aagcaaaat  1920
cattggagt  aaaagtttg  gaagatttt  taatgtcga  tcattgagt  aactaacct  1980
agtgattct  acggactgt  atcagggta  cagttagct  tccaaaggc  ccctcaggc  2040
gccacgggt  ccactctct  cctgccctg  gagactcaa  ggcagtgtc  acagagttc  2100
agaagacgc  tgctcccct  ctgtgggct  gtttggtcc  tgactagca  tcctgccaa  2160
taccacacc  gcacactgt  accgcgctt  ttctgtttc  ttctgagcg  aactgtggg  2220
cctggggat  tctgtcctt  gcctgtttt  gacaggtgc  ggcctttga  ctggaactg  2280
ttgactgaa  caggcactg  ctttccatg  gaagagagg  caggtagtg  cttgtcggg  2340
agctggcga  gtatagact  ggttttgtc  tttatccat  aggtgctct  acttgctta  2400
ctccctagt  aacatggat  ggggctgtc  ggaataatg  attttatta  aagcacaaa  2460
ttggtagca  tttttaaat  tcatttcta  accacaaac  agcctttat  ttaaaagaa  2520
aaagtgaaa  tgtgctgaa  agggttgta  gctcgtggc  gtttgtgcc  cggggacct  2580
gtggtcaca  tctgaatgg  gccctgtca  agggtgctc  tgagaagga  gagtgtggg  2640
gtggagacg  ctcattcgg  ctgtgactt  agacagcag  atgttattc  gcgtctgaa  2700
agvccaatt  catttttac  tttttacgg  tgaggtatt  ttgagtctg  ccacttgga  2760
gagagccat  gttctacac  ccattcatg  cacttgaga  cggtgaggt  accgatact  2820
gcattctct  aaggccaga  atcagttaa  tgcaaggtt  gttgacgag  tggtcacgg  2880
tccctccta  ccccagtgc  ggaaagctg  ggcaggaag  ccgtgtgag  tcacaacag  2940
ctgagctac  cagtaggaa  ccctccccc  aaaataaaa  aaaagtttg  tgtctaaaa  3000
aaaaaaaaa  aaaaaaaaa  aaaaaaa  3027



<210> 8548
<211> 467
<212> PRT
<213> Rattus norvegicus
<308> O08587
<400> 8548

Met Ala Lys Arg Val Ala Glu Lys Glu Leu Thr Asp Arg Asn Trp Asp 
  1               5                  10                  15
Glu Glu Asp Glu Val Glu Glu Met Gly Thr Phe Ser Val Ala Ser Glu 
             20                  25                  30
Glu Val Met Lys Asn Arg Ala Val Lys Lys Ala Lys Arg Arg Asn Ile 
         35                  40                  45
Gly Phe Glu Ser Asp Ser Gly Gly Ala Phe Lys Gly Phe Lys Gly Leu 
     50                  55                  60
Val Val Pro Ser Gly Gly Gly Gly Phe Ser Gly Phe Gly Gly Gly Ser 
 65                  70                  75                  80
Gly Gly Lys Pro Leu Glu Gly Leu Thr Asn Gly Asn Ser Thr Asp Ser 
                 85                  90                  95
Ala Thr Pro Phe Ser Ser Ala Lys Thr Ala Ala Glu Pro Lys Ala Ala 
             100                105                110
Phe Gly Ser Phe Ala Val Asn Gly Pro Thr Thr Leu Val Asp Lys Lys 
         115                120                125
Ile Ser Ser Pro Lys Cys Asn Ser Ser Asn Gln Pro Pro Ser Ser Gly 
     130                135                140
Pro Ala Ser Ser Thr Ser Cys Thr Gly Asn Thr Tyr His Lys Gln Leu 
 145                150                155                160
Ala Gly Leu Asn Cys Ser Val Arg Asp Trp Ile Val Lys His Val Asn 
                 165                170                175
Thr Asn Pro Leu Cys Asp Leu Thr Pro Ile Phe Lys Asp Tyr Glu Arg 
             180                185                190
Tyr Leu Ala Thr Ile Glu Lys Gln Leu Glu Asn Gly Gly Ser Ser Ser 
         195                200                205
Ser Glu Arg Gln Thr Asp Arg Ala Thr Ala Ala Met Glu Pro Pro Ser 
     210                215                220
Leu Phe Gly Ser Thr Lys Leu Gln Gln Asp Ser Pro Phe Ser Phe His 
 225                230                235                240
Gly Asn Lys Ala Glu Asp Thr Ser Glu Lys Leu Glu Phe Thr Ala Glu 
                 245                250                255
Lys Lys Ser Asp Ala Ala Gln Gly Ala Thr Ser Ala Ser Phe Asn Phe 
             260                265                270
Gly Lys Lys Ile Glu Ser Ser Val Leu Gly Ser Leu Ser Ser Gly Ser 
         275                280                285
Leu Thr Gly Phe Ser Phe Ser Pro Gly Asn Ser Ser Leu Phe Gly Lys 
     290                295                300
Asp Ala Ala Gln Ser Lys Ala Ala Ser Ser Pro Phe Ser Ala Lys Ala 
 305                310                315                320
Ser Glu Ser Gln Ala Gly Gly Ser Ser Ser Glu Cys Arg Asp Gly Glu 
                 325                330                335
Glu Glu Glu Ser Asp Glu Pro Pro Lys Val Val Val Thr Glu Val Lys 
             340                345                350
Glu Glu Asp Ala Phe Tyr Ser Lys Lys Cys Lys Leu Phe Tyr Lys Lys 
         355                360                365
Asp Asn Glu Phe Lys Glu Lys Gly Val Gly Thr Leu His Leu Lys Pro 
     370                375                380
Thr Ala Thr Gln Lys Thr Gln Leu Leu Val Arg Ala Asp Thr Asn Leu 
 385                390                395                400
Gly Asn Ile Leu Leu Asn Val Leu Ile Pro Pro Asn Met Pro Cys Thr 
                 405                410                415
Arg Thr Gly Lys Asn Asn Val Leu Ile Val Cys Val Pro Asn Pro Pro 
             420                425                430
Leu Asp Glu Lys Gln Pro Thr Leu Pro Val Thr Met Leu Ile Arg Val 
         435                440                445
Lys Thr Ser Glu Asp Ala Asp Glu Leu His Lys Ile Leu Leu Gln Lys 
     450                455                460
Lys Asp Val 
 465



<210> 8549
<211> 1757
<212> DNA
<213> Homo sapiens
<308> NM_007172
<400> 8549

cgagcacta  gtcctctga  ttccgcagc  cagcaccgg  agcggccga  cgcgctcag  60
ccggcgacc  ctgcgggct  cagacccct  cgccgctgc  ccccgggtt  cgccgcaac  120
aagacccag  gagtgcagc  gcggccgct  aggaggttc  aaaacatgg  caaaagaaa  180
gccgagaag  aactgacag  taggaattg  gatcaagaa  atgaagctg  agaggtggg  240
acattctcc  tggccagtg  ggaagtctt  aagaataga  ccataaaga  agcaaagcg  300
agaaatgtt  gatttgaat  tgacactgg  ggagccttt  aaggtttta  aggtttggt  360
gtaccttct  gaggaggac  cttttctgg  tttggtagt  gcgctggag  gaagccttt  420
gaaggactg  cgaatggaa  caacataac  agtgcccct  ccttcgcca  tgcaaaggc  480
gcggcagat  ccaaggtag  ctttggttc  cttgctgca  atggcccta  caccttggt  540
gataaagtt  caaatccca  aactaatgg  gacagtcag  agccctcct  ctctggcct  600
gcttccagt  aagcttgtg  cggaaatgc  tatcacaag  agttggccg  cttgaactg  660
tccgtgcgg  attggatag  gaagcacgt  aatacaaac  ccctctgtg  tctgacacc  720
atctttaaa  actatgaga  atatttagc  aacattgaa  agcaacacg  gaacagtgg  780
aggaattct  aaagtgaat  taacaaagt  gcagctgaa  cacagtctc  ttccctttt  840
ggctcaaca  aattacagc  agagtcaag  tttttgttt  atggcaaca  aactgaaga  900
acacctgac  agaagatgg  ggtggcatc  gaaaagaaa  cggacccat  atcactagg  960
gcgacaagt  cctcattta  tttcggcaa  aaagttgat  gctctgttt  gggctcatt  1020
agctctgtc  ccctgactg  attttcttt  tcccctgga  actccagtt  atttggcaa  1080
gatactacc  agagtaaac  agtctcttc  ccatttccc  ctaaaccat  ggagggcca  1140
gcagaaggt  acagtggtg  atgcaaagg  ggagatgaa  aagagaatg  tgagccacc  1200
aaagtagta  ttaccgaag  aaaagaaga  gatgctttt  actccaaaa  gtgtaaact  1260
ttttacaag  aggacaatg  gtttaaaga  aaaggcata  gtactctgc  tttaaaacc  1320
acagcaaat  agaagacac  gcttttggt  cgggcagac  ccaatttag  caacatatt  1380
ctgaacgtt  tgattccac  caatatgcc  tgtacgcga  cagggaaga  taacgttct  1440
atcgtctgt  ttccaaatc  accaattga  gagaagaat  ccaccatgc  agtcaccat  1500
ttgattcgg  taaaaacca  cgaggatgc  gacgagttg  acaaaattt  actggagaa  1560
aaggatgcc  gaacacgca  agtcggctg  agaattatt  ccaagttgc  gctgcttcc  1620
ccgcccctt  aagttagtc  gtttttctt  tcttctttg  cattctaag  acttataga  1680
aacttaaaa  ttttgtgag  aagattaat  tggccaata  aacctttaa  tgttaagtg  1740
caaaaaaaa  aaaaaaa  1757



<210> 8550
<211> 468
<212> PRT
<213> Homo sapiens
<308> Q9UKX7
<400> 8550

Met Ala Lys Arg Asn Ala Glu Lys Glu Leu Thr Asp Arg Asn Trp Asp 
  1               5                  10                  15
Gln Glu Asp Glu Ala Glu Glu Val Gly Thr Phe Ser Met Ala Ser Glu 
             20                  25                  30
Glu Val Leu Lys Asn Arg Ala Ile Lys Lys Ala Lys Arg Arg Asn Val 
         35                  40                  45
Gly Phe Glu Ser Asp Thr Gly Gly Ala Phe Lys Gly Phe Lys Gly Leu 
     50                  55                  60
Val Val Pro Ser Gly Gly Gly Arg Phe Ser Gly Phe Gly Ser Gly Ala 
 65                  70                  75                  80
Gly Gly Lys Pro Leu Glu Gly Leu Ser Asn Gly Asn Asn Ile Thr Ser 
                 85                  90                  95
Ala Pro Pro Phe Ala Ser Ala Lys Ala Ala Ala Asp Pro Lys Val Ala 
             100                105                110
Phe Gly Ser Leu Ala Ala Asn Gly Pro Thr Thr Leu Val Asp Lys Val 
         115                120                125
Ser Asn Pro Lys Thr Asn Gly Asp Ser Gln Gln Pro Ser Ser Ser Gly 
     130                135                140
Leu Ala Ser Ser Lys Ala Cys Val Gly Asn Ala Tyr His Lys Gln Leu 
 145                150                155                160
Ala Ala Leu Asn Cys Ser Val Arg Asp Trp Ile Val Lys His Val Asn 
                 165                170                175
Thr Asn Pro Leu Cys Asp Leu Thr Pro Ile Phe Lys Asp Tyr Glu Lys 
             180                185                190
Tyr Leu Ala Asn Ile Glu Gln Gln His Gly Asn Ser Gly Arg Asn Ser 
         195                200                205
Glu Ser Glu Ser Asn Lys Val Ala Ala Glu Thr Gln Ser Pro Ser Leu 
     210                215                220
Phe Gly Ser Thr Lys Leu Gln Gln Glu Ser Thr Phe Leu Phe His Gly 
 225                230                235                240
Asn Lys Thr Glu Asp Thr Pro Asp Lys Lys Met Glu Val Ala Ser Glu 
                 245                250                255
Lys Lys Thr Asp Pro Ser Ser Leu Gly Ala Thr Ser Ala Ser Phe Asn 
             260                265                270
Phe Gly Lys Lys Val Asp Ser Ser Val Leu Gly Ser Leu Ser Ser Val 
         275                280                285
Pro Leu Thr Gly Phe Ser Phe Ser Pro Gly Asn Ser Ser Leu Phe Gly 
     290                295                300
Lys Asp Thr Thr Gln Ser Lys Pro Val Ser Ser Pro Phe Pro Thr Lys 
 305                310                315                320
Pro Leu Glu Gly Gln Ala Glu Gly Asp Ser Gly Glu Cys Lys Gly Gly 
                 325                330                335
Asp Glu Glu Glu Asn Asp Glu Pro Pro Lys Val Val Val Thr Glu Val 
             340                345                350
Lys Glu Glu Asp Ala Phe Tyr Ser Lys Lys Cys Lys Leu Phe Tyr Lys 
         355                360                365
Lys Asp Asn Glu Phe Lys Glu Lys Gly Ile Gly Thr Leu His Leu Lys 
     370                375                380
Pro Thr Ala Asn Gln Lys Thr Gln Leu Leu Val Arg Ala Asp Thr Asn 
 385                390                395                400
Leu Gly Asn Ile Leu Leu Asn Val Leu Ile Pro Pro Asn Met Pro Cys 
                 405                410                415
Thr Arg Thr Gly Lys Asn Asn Val Leu Ile Val Cys Val Pro Asn Pro 
             420                425                430
Pro Ile Asp Glu Lys Asn Ala Thr Met Pro Val Thr Met Leu Ile Arg 
         435                440                445
Val Lys Thr Ser Glu Asp Ala Asp Glu Leu His Lys Ile Leu Leu Glu 
     450                455                460
Lys Lys Asp Ala 
 465



<210> 8551
<211> 1550
<212> DNA
<213> Rattus norvegicus
<308> U42413
<400> 8551

agcgctcca  ctccggaga  tgaacactc  caagagacc  cggaatcga  cagtagtgt  60
tacaccacc  tcatgaagt  tcatcgctg  tatgacctg  tccccacaa  ctccaagct  120
gtggtattt  atacttcgc  gcaggtaaa  aaagccttc  ttgccctgg  gactaacgg  180
gttcgtgct  cccctttgt  ggatagtaa  aagcagagc  ttgtgggca  gctgaccat  240
actgacttc  tcaatattc  gcaccgata  tacaagtca  ccctggtgc  gatctatga  300
ctggaggag  acaagatag  gacttggag  gaggtctac  tgcaagact  ctttaagcc  360
cttgtctgc  tttctccaa  tgccagctt  ttcgatgct  tctcttcat  aattcgaaa  420
aagatccac  ggcttccag  tattgaccc  gagtcaggc  acaccttgt  cattcttac  480
cacaagcgg  tcctcaagt  cctcaagtt  tttatcact  agttcccca  gccggaatt  540
atgtctaag  ctctggaag  gctacagat  ggcacctac  ccaatattg  catggtccg  600
accactaca  ctgtctatg  ggctctggg  atctttgta  agcaccgag  ctccgcctt  660
cctgtggtg  atgagaaag  gcgtgtggt  gacatctac  ccaagtttg  tgtgattaa  720
ttggcagca  aaaagacat  caacaacct  gatgtgtct  tgacaaaag  cctacagca  780
cggtcacac  acttcgagg  tgttctcaa  tgctaccta  atgagactc  agaagcaat  840
atcaataga  tggtggaag  agaggttca  cgtctggtg  tggtggatg  acatgacgt  900
gtcaagggc  ttgtatcgc  gtctgacat  ttacaggct  tggtgctca  aggtggaga  960
aagaagccc  gagcatggg  cggaacagg  agtgcctgg  gagatggcc  cctcactgc  1020
tgcctgctg  aagagccgg  atcagatgg  atcctgaga  aacggagtc  tccctcagg  1080
gctccacgc  cactgtcta  aactagaga  ggggaaagg  ggagaagga  tgttagctt  1140
tctcaccat  gtgctacac  tgagaaaac  cttgtcagc  tagccagcc  cagtcgctc  1200
tcacagccc  cttgtgggt  aaccatggg  tttgtgctc  tcaggcaga  cctgatctc  1260
aagagatcc  gagacctca  cacgcccca  ctctgtctc  gcccttact  cactaagag  1320
atagctctg  agaagtctt  gtaaagtat  tttattcct  tttcttcac  ctgtgtgga  1380
gaggctggc  tgtttgctg  cagtccttc  catgagtct  gggaggtgc  tcccggctc  1440
tggcctgtg  agacgaagg  agatgcctc  gtggaggag  gcggtgggt  gggacccaa  1500
attaatgct  tttgtggcg  acctaatta  atgacaagg  ttcatcatgg  1550



<210> 8552
<211> 330
<212> PRT
<213> Rattus norvegicus
<308> P80385
<400> 8552

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
  1               5                  10                  15
Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
             20                  25                  30
Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
         35                  40                  45
Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
     50                  55                  60
Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
 65                  70                  75                  80
Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                 85                  90                  95
Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
             100                105                110
Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
         115                120                125
Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
     130                135                140
Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
 145                150                155                160
Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                 165                170                175
Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
             180                185                190
Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
         195                200                205
Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
     210                215                220
Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
 225                230                235                240
Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                 245                250                255
Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
             260                265                270
Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
         275                280                285
Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
     290                295                300
His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
 305                310                315                320
Leu Val Leu Thr Gly Gly Glu Lys Lys Pro 
                 325                330



<210> 8553
<211> 1578
<212> DNA
<213> Homo sapiens
<308> U42412
<400> 8553

gcgccctta  agatggtga  ggggctcat  ctctgagta  aaggtggtg  cctccagga  60
cggtgggat  atgagggcc  gggcgcctc  tgcaatgga  acggtcatt  cttcagata  120
ctccccagc  gtggaaaat  agcatcctc  agagacccc  gaatccaac  atagcgtgt  180
tacttcctt  atgaagtct  atcgctgct  tgacctgat  cccacaagc  ccaaattgg  240
tgtatttga  acgtccctg  aggtgaaga  agctttttt  gctttggtg  ctaacggtg  300
acgagctgc  cctttatgg  atagtaaga  gcaaagttt  gtgggcatg  tgaccatca  360
tgatttcat  aatatcctg  accgctact  taaatcagc  ttggtacag  tctatgagc  420
agaagaaca  aagatagaa  cttggagag  ggtgtatct  caggactcc  ttaaaccgc  480
tgtctgcat  tctcctaat  ccagcttgt  tgatgctgt  tcttcatta  ttcggaaca  540
gatccacag  ctgccagtt  ttgacccag  atcaggcaa  actttgtac  tcctcaccc  600
caagcgcat  ctgaagttc  tcaaattgt  tatcactga  ttccccaag  cagagttca  660
gtccaagtc  ctggaagag  tacagattg  cacctatgc  aatattgct  tggttcgca  720
taccacccc  gtctatgtg  ctctgggga  ttttgtaca  catcgagtc  cagccctgc  780
agtggtgga  gagaagggg  gtgtggtgg  catctactc  aagtttgat  ttatcaatc  840
ggcagcaga  aagacctac  acaacctag  tgtatctgt  actaaagcc  tgcaacatc  900
atcacatta  tttgagggt  ttctcaagt  ctacctgca  gagactctg  agaccatca  960
caacaggct  gtggaagca  aggttcacc  acttgtagt  gtggatgaa  atgatgtgg  1020
caagggaat  gtatcactg  ctgacatcc  gcaggccct  gtgctcaca  gtggagaga  1080
gaagccctg  gctggggga  ggggtcatg  agcaccagg  gatatgccc  actcactgc  1140
tgctggaag  tctgtggga  tcagatgaa  cttgaggga  ttgtgactc  gttccctgt  1200
cagggtccc  tgcccttct  tctgggagc  agggaaggt  tgggggagg  aagagaatg  1260
atttatagc  acccttacc  tcacacata  acttgaaaa  actttcagc  tagccagtt  1320
tagcccctg  cctcttaga  atatccccc  ttctgggtg  actataggc  ctgtgcctc  1380
cagacaaat  ctgatctct  agagatccc  agacctcac  tgcctctgc  tccatcttg  1440
ccctgattc  accctaaga  aatagcaca  caaaattct  cataaagat  tttttattc  1500
cctgttccg  gctatatgg  ggaggccaa  tccatttag  gacatttct  cccataatg  1560
gagtgggga  gattgtgg  1578



<210> 8554
<211> 331
<212> PRT
<213> Homo sapiens
<308> P54619
<400> 8554

Met Glu Thr Val Ile Ser Ser Asp Ser Ser Pro Ala Val Glu Asn Glu 
  1               5                  10                  15
His Pro Gln Glu Thr Pro Glu Ser Asn Asn Ser Val Tyr Thr Ser Phe 
             20                  25                  30
Met Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu 
         35                  40                  45
Val Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu 
     50                  55                  60
Val Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln 
 65                  70                  75                  80
Ser Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His 
                 85                  90                  95
Arg Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His 
             100                105                110
Lys Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro 
         115                120                125
Leu Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser 
     130                135                140
Leu Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser 
 145                150                155                160
Gly Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu 
                 165                170                175
Lys Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser 
             180                185                190
Leu Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg 
         195                200                205
Thr Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg 
     210                215                220
Val Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile 
 225                230                235                240
Tyr Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn 
                 245                250                255
Asn Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr 
             260                265                270
Phe Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Thr Ile 
         275                280                285
Ile Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp 
     290                295                300
Glu Asn Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln 
 305                310                315                320
Ala Leu Val Leu Thr Gly Gly Glu Lys Lys Pro 
                 325                330



<210> 8555
<211> 2104
<212> DNA
<213> Rattus norvegicus
<308> U42627
<400> 8555

gcacgagac  gggttggat  tgaggtgca  cctcagagg  attaggagc  gctagactt  60
tttcttttt  cctttttct  ctctcagtg  cacggagtc  gaattaatt  gatttcatt  120
actgggtag  aacaaaact  ggcactttc  ttcagagag  ttcattgac  ctgagagtg  180
tctggtgca  agggaccac  ggcttggct  ctgtcgcct  ccctaaccg  tagcttcgg  240
ttgggaaag  ccgaatcaa  cccggctcc  agagccgga  cttctcacg  cttgcttgg  300
ctatgcctg  ctcgagggg  gtctgctag  caccccgcc  tctcctgca  ctcgacccc  360
atgatagat  cgctcagac  cgtgccctt  gcgtcggaa  tggcgatca  caagacggt  420
gcgtggctc  acgagcagc  ggagctggg  aacgaacag  tgctgctga  ggactgccg  480
ccgcaggag  tgtacgagt  gtcgcacat  gaatctgcc  tcaacgtgg  catcccggg  540
atcatgctg  ggcgtctgc  gaagggcaa  ctgccggtg  gcgcgctat  cacgcgctg  600
gaggaccgg  accgcttta  caggcgctg  ggcaccgac  ccgtggtgc  ctacgacga  660
aacagcagc  actggaatg  gaacacagg  ggagagtcg  tcctcgggc  gctgctcaa  720
aaactcaaa  acgagggct  ccgggcgtt  taccttgaa  gtggcttca  taagttcca  780
gccgagttc  ccctgcact  cgagaccaa  ctagacggc  cgtgcagca  cagctcccc  840
cccttgcca  tgctgggac  cgggggcct  aggatcagc  ccgactctt  ctcggacat  900
gagtctgac  ttgaccgag  ccccaatag  gcaacggac  ccgatggca  cccgctgtc  960
aacagccag  cttccttcc  ggtggagat  ttgcccttc  tttacctgg  ctgtgccaa  1020
gactctact  acttggacg  gttggaaga  tttggcatc  agtacatct  gaacgtcac  1080
cccaatctg  ccaatctgt  tgagaatgc  ggggagttc  agtacaagc  aattcctat  1140
tctgatcac  ggagccaaa  cctgtccca  tttttccct  aggccattt  tttcataga  1200
gaagcccga  gcaaaaact  tggtgtcct  gtgcattgc  tggcgggca  cagccgctc  1260
gtcacggtg  cagtggctt  ccttatgca  aagctcaac  tgtccatga  cgatgctta  1320
gacattgtc  aaatgaaga  gtccaacat  tctcccaac  tcaacttca  gggccagct  1380
cttgacttt  aaaggaccc  gggactcag  agcccctgt  acaatcgtg  ccccgcaca  1440
cagctctac  tcaccgcgc  ctccaacca  aatgtctac  aagtggact  cctgcaatc  1500
acgtgaaag  cacccacct  tcctagccg  gagtgtctc  ttccttcag  ttctcttgg  1560
cagcatcga  caggctgct  tctttgtgt  tggccccag  tgtcaaaaa  gtcaccagc  1620
gtctgtatt  gacaaggtt  ccaagtgca  aattggtta  tacggaggg  gagatttgc  1680
ccattcatt  ttttttgga  ggacagggt  tgctgtcta  atccaggca  taggtttgc  1740
tttgtaccc  agcctaccc  agcagggac  ggacctcca  ccagataga  ggtaggaca  1800
aggagccgg  gataggagc  tgtgttcct  agggccaca  atggctgtt  cctgttgca  1860
ctggaacca  ctatattgt  ttcagtgaa  actgattca  ctttgcgta  agtggagcc  1920
aagagattt  agctctgta  ttgtggtat  ggttttgaa  acaaaagaa  tgatccttt  1980
atttgatta  tgtaaatat  tgatcttca  ttgagagtg  ttgtttggc  tgtgtttgg  2040
ttttaatct  tgggtttaa  cgagatcca  agggagaaa  agcagtatg  ctcgtgccg  2100
attc  2104



<210> 8556
<211> 381
<212> PRT
<213> Rattus norvegicus
<308> Q64346
<400> 8556

Met Ile Asp Thr Leu Arg Pro Val Pro Phe Ala Ser Glu Met Ala Ile 
  1               5                  10                  15
Ser Lys Thr Val Ala Trp Leu Asn Glu Gln Leu Glu Leu Gly Asn Glu 
             20                  25                  30
Gln Leu Leu Leu Met Asp Cys Arg Pro Gln Glu Leu Tyr Glu Ser Ser 
         35                  40                  45
His Ile Glu Ser Ala Ile Asn Val Ala Ile Pro Gly Ile Met Leu Arg 
     50                  55                  60
Arg Leu Gln Lys Gly Asn Leu Pro Val Arg Ala Leu Phe Thr Arg Cys 
 65                  70                  75                  80
Glu Asp Arg Asp Arg Phe Thr Arg Arg Cys Gly Thr Asp Thr Val Val 
                 85                  90                  95
Leu Tyr Asp Glu Asn Ser Ser Asp Trp Asn Glu Asn Thr Gly Gly Glu 
             100                105                110
Ser Val Leu Gly Leu Leu Leu Lys Lys Leu Lys Asp Glu Gly Cys Arg 
         115                120                125
Ala Phe Tyr Leu Glu Gly Gly Phe Ser Lys Phe Gln Ala Glu Phe Ala 
     130                135                140
Leu His Cys Glu Thr Asn Leu Asp Gly Ser Cys Ser Ser Ser Ser Pro 
 145                150                155                160
Pro Leu Pro Val Leu Gly Leu Gly Gly Leu Arg Ile Ser Ser Asp Ser 
                 165                170                175
Ser Ser Asp Ile Glu Ser Asp Leu Asp Arg Asp Pro Asn Ser Ala Thr 
             180                185                190
Asp Ser Asp Gly Ser Pro Leu Ser Asn Ser Gln Pro Ser Phe Pro Val 
         195                200                205
Glu Ile Leu Pro Phe Leu Tyr Leu Gly Cys Ala Lys Asp Ser Thr Asn 
     210                215                220
Leu Asp Val Leu Glu Glu Phe Gly Ile Lys Tyr Ile Leu Asn Val Thr 
 225                230                235                240
Pro Asn Leu Pro Asn Leu Phe Glu Asn Ala Gly Glu Phe Lys Tyr Lys 
                 245                250                255
Gln Ile Pro Ile Ser Asp His Trp Ser Gln Asn Leu Ser Gln Phe Phe 
             260                265                270
Pro Glu Ala Ile Ser Phe Ile Asp Glu Ala Arg Gly Lys Asn Cys Gly 
         275                280                285
Val Leu Val His Cys Leu Ala Gly Ile Ser Arg Ser Val Thr Val Thr 
     290                295                300
Val Ala Tyr Leu Met Gln Lys Leu Asn Leu Ser Met Asn Asp Ala Tyr 
 305                310                315                320
Asp Ile Val Lys Met Lys Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe 
                 325                330                335
Met Gly Gln Leu Leu Asp Phe Glu Arg Thr Leu Gly Leu Ser Ser Pro 
             340                345                350
Cys Asp Asn Arg Val Pro Ala Gln Gln Leu Tyr Phe Thr Ala Pro Ser 
         355                360                365
Asn Gln Asn Val Tyr Gln Val Asp Ser Leu Gln Ser Thr 
     370                375                380



<210> 8557
<211> 347
<212> DNA
<213> Rattus norvegicus
<308> U42719
<400> 8557

cagacccgc  actttctgg  ccgggcttc  tgccgcctt  gtttggagc  tagcaaaga  60
tacttaatc  tggggatgg  cggagtcac  agtgacctc  agggagacc  ccagtactt  120
ctggactca  acagttgga  cgaggagat  ccatctgag  acctgtgca  gagcacccg  180
cagcgggca  cctgtacca  ctcaatgac  tcctgcagg  gtacagaag  caggggtgc  240
aggtgtgag  gcgtcggac  ctggatccc  gagctcagc  ccagggtca  ggcctctca  300
gaagcaggg  ctgcttaac  gggtaaata  ataaaactt  tgacagt  347



<210> 8558
<211> 105
<212> PRT
<213> Rattus norvegicus
<308> AAA91231
<400> 8558

Gln Thr Arg Asn Phe Leu Val Arg Ala Ser Cys Arg Leu Arg Leu Glu 
  1               5                  10                  15
Pro Ser Lys Glu Tyr Leu Ile Met Gly Met Asp Gly Val Thr Ser Asp 
             20                  25                  30
Leu Lys Gly Asp Pro Gln Tyr Leu Leu Asp Ser Asn Ser Trp Ile Glu 
         35                  40                  45
Glu Met Pro Ser Glu His Leu Cys Arg Ser Thr Arg Gln Arg Ala Ala 
     50                  55                  60
Cys Thr Ser Ser Met Thr Ser Cys Arg Ser Thr Glu Ala Arg Gly Ala 
 65                  70                  75                  80
Arg Cys Glu Gly Val Gly Leu Trp Ile Pro Glu Leu Ser Pro Arg Val 
                 85                  90                  95
Arg Ala Ser His Glu Ala Gly Pro Ala 
             100                105



<210> 8559
<211> 5417
<212> DNA
<213> Homo sapiens
<308> NM_007293
<400> 8559

agaaggtag  agacagaca  acggatcta  cctctcttg  atcctccag  catgaggct  60
ctctggggg  tgatctggg  atccagctt  ttcacctta  ctctgcaga  gcccaggtt  120
ctcttgttc  ctccttctg  ggttcatct  ggggtcccc  tatcggtgg  ggtgcagct  180
caggatgtg  cccgaggac  ggtagtgaa  ggatcagtg  tcctgagaa  cccatctcg  240
aataatgtc  cctgctccc  aaaggtgga  ttcaccctt  gctcagaaa  agacttcgc  300
ctcctcagt  tccaggtgc  cttgaaaga  gcgaagagc  gtggcctcc  tcaactcct  360
agaggccct  aggtccagc  ggtggccca  tcgccatgg  taaaggact  tctgtccag  420
acgacaaac  tccagggta  caacctgct  ttctcctct  gccgggggc  cctcttttt  480
cagacggac  agcccattt  caaccctgg  cagcgggtt  ggtaccggg  ctttgctct  540
gatcagaag  tgcgcccga  cactgacac  atcacagtc  tggtggaga  ctctcacgg  600
ctccgcgtg  ggaagaagg  ggtgtacat  ccctcgtcc  tcttccagg  tgactttgt  660
atcccagac  tctcagagc  agggacctg  aagatctca  cccgattct  agatggcct  720
gaatccaac  gcagcaccc  gtttgaggt  aagaaatat  tccttccca  ctttgaggt  780
aagatcacc  ctggaaagc  ctacatcct  acggtgcca  gccatcttg  tgaaatgca  840
ttagacatc  aggccaggt  catctatgg  aagccagtg  agggggtgg  atatgtgcg  900
tttgggctc  tagatgagg  tggtaagaa  actttcttt  gggggctgg  gagtcagac  960
aagctggtg  atggacaga  ccacatttc  ctctcaaag  cagagttcc  ggacgccct  1020
gagaagctg  atatgggca  tactgacct  caggggctg  gcctctacg  tgctgcagc  1080
atcattgag  ctccaggtg  ggagatgga  gaggcagag  tcacatcct  gtattttgt  1140
tcatctccc  tctccttgg  tcttagcaa  accaagcga  accttgtgc  tggggcccc  1200
ttcctgctg  aggccttgg  ccgtgagat  tcaggctcc  cagcttctg  cattcctgt  1260
aaagtttct  ccacggtgt  ttctcctgg  tctgttcct  aagcccagg  cattcagca  1320
aacacagac  ggagcggcc  agtcagcat  ccaataatt  tccctcaga  catctcaga  1380
ctgcagctc  cagtatctg  aggctcccc  catccagcg  tagccaggc  cactgtggc  1440
gccccacct  caggaggcc  cgggtttct  tctattgag  ggccggatt  tcgacctcc  1500
cgtgttggg  acactctga  cctgaactt  cgagccgtg  gcagtgggg  caccttttc  1560
cattactac  acatgatcc  atcccgagg  cagatcgtg  tcatgaatc  agagcccaa  1620
aggaccctg  cctcggtct  ggtgtttgt  gaccatcac  tggcaccct  cttctactt  1680
gtggccttc  actaccatg  agaccaccc  gtggccaac  ccctgcgag  ggatgtcca  1740
gctggggcc  gcgagggca  gctggagct  agcgtggac  gtgccaagc  gtaccggaa  1800
ggggagtcc  tgaagctcc  cttagaaac  gactcccta  ccctggtgg  gctgggagc  1860
ttggacaca  ctctgtatg  tgcaggcag  aagtcccac  agcccctca  catgggcaa  1920
gtctttgaa  ctatgaaca  ctatgacct  ggctgtggt  ctgggggtg  ggacagtgc  1980
cttcaggtg  tccaggcag  gggcctggc  ttttctgat  gagaccagt  gaccttatc  2040
agaaagaga  taagctgtc  caaggagaa  acaacccgg  aaaagagaa  cgtgaactt  2100
caaaaggcg  ttaatgaga  attgggtca  tatgcttcc  cgacagcca  gcgctgctg  2160
caggatggg  tgacacgtc  gcccatgat  cgttcctgc  agcagcggg  agcccgcgt  2220
cagcagccg  actgccggg  gcccttcct  tcctgctgc  aatttgctg  gagtctgcg  2280
aagaagagc  gggacaagg  ccaggcggg  ctccaacga  ccctggaga  cctgcagga  2340
gaggacctg  ttgatgagg  tgacattcc  gtgcgcagc  tcttcccag  gaactggct  2400
tggagagtg  aaacagtgg  ccgctttca  atattgaca  tgtggctcc  cgactctct  2460
accacgtgg  agatccatg  cctgagcct  tccaaaacc  aaggcctat  tgtggccac  2520
ccagtccag  tccgggtgt  ccgcgagtt  cacctgcac  tccgcctgc  catgtctgt  2580
cgccgcttt  agcagctgg  gctgcggcc  gtcctctat  actacctgg  taaaaacct  2640
actgtgagc  tccacgtgt  cccagtgga  gggctgtgc  tggctgggg  cggagggct  2700
gcccagcag  tgctggtgc  tgcgggctc  gcccggcct  ttgccttct  tgtggtgcc  2760
acggcagcc  ccgctgtgt  tctgaaggt  gtggctcga  ggtccttcg  attccctgt  2820
ggagatgcg  tgtccaagg  tctgcagat  gagaaggaa  gggccatcc  tagagagga  2880
ctggtctat  aactcaacc  cttggacca  cgaggccgg  ccttggaaa  acctggcaa  2940
tctgatccc  atatgatcc  tgatgggga  tttaacagc  acgtcaggg  tacagcctc  3000
gatccattg  acactttag  ctctgaggg  gccttgtca  caggaggcg  ggcctccct  3060
ttgaggctt  ctcgaggct  tggggagca  accatgatc  acttggctc  gacactggc  3120
gcttcccgc  acctggaca  gacagagca  tggagcaca  tgcctcccg  gaccaagga  3180
cacgccgtg  atctgatcc  gaaaggcta  atgcggatc  agcagtttc  gaaggcgga  3240
ggttcctat  cggcttggt  gtcacggga  agcagcacc  ggctcacag  ctttgtgtt  3300
aaggtcctg  gtttggccc  ggagcaggt  ggaggctcg  ctgagaaac  gcaggagac  3360
tctaactgg  ttctgtccc  gcagcaggc  gacggctcg  tccaggacc  ctgtccagt  3420
ttagacagg  gcatgcagg  gggtttggt  ggcaatgat  agactgtgg  actcacagc  3480
tttgtgacc  tcgcccttc  tcatgggct  gccgtcttc  aggatgagg  tgcagagcc  3540
ttgaagcag  gagtggaag  ctccatctc  aaggcaaac  catttttgg  ggagaaagc  3600
agtgctggg  tcctgggtg  ccacgcagc  gccatcacg  cctatgccc  gtcactgac  3660
aaggcgcct  tggacctgc  cggtgttgc  cacaacaac  tcatggcaa  ggcccagga  3720
actggagat  acctgtact  gggctcagt  actggttct  agagcaatg  cgtgtcgcc  3780
accccggct  ctcgcaacc  atccgaccc  atgccccag  ccccagccc  gtggattga  3840
accacagcc  acgccctgc  gcacctcct  cttcacgag  gcaaagcag  gatggcaga  3900
caggcttcg  cctggctca  ccgtcaggg  agcttccaa  ggggattcc  cagtaccca  3960
gacacggtg  ttgccctgg  tgccctgtc  gcctactgg  ttgcctccc  caccactga  4020
gagaggggt  tcaatgtga  tctcagctc  acaggccgg  atgggttca  gtcccacgc  4080
ctgcagctg  acaaccgcc  gattcgcgg  ctggaggag  agctgcagt  ttccttggg  4140
agcaagatc  atgtgaagg  gggaggaaa  agcaaagga  ccctgaagg  ccttcgtac  4200
tacaatgtc  tggacatga  gaacacgac  tgccaggac  tacagatag  agtgacagt  4260
aaaggccac  tcgagtaca  gatggaagc  aacgaggac  atgagtacg  tgagcttcc  4320
gccaaggat  acccagatg  ccctctgca  cccgtgaca  ccctgcagc  gtttgaggg  4380
cggaggaac  gccgcagga  ggaggcgcc  aaggtggtg  aggagcagg  gtccagggt  4440
cactacacc  tgtgcatct  gcggaacgg  aaggtgggg  tgtctggca  ggccatcgc  4500
gacgtcacc  tcctgagtg  attccacgc  ctgcgtgct  acctggaga  gctgacctc  4560
ctctctgac  gttacgtga  tcactttga  accgagggg  cccacgtcc  gctgtattt  4620
gactcggtc  ccacctccc  ggagtgcgt  ggctttgag  ctgtgcagg  agtgccggt  4680
gggctggtg  agccggcca  cgcaaccct  tacgactac  acaaccccg  gcgcagatg  4740
tctgtgttt  acggggcac  aagtaagag  agactcttg  ccaccttgt  ttctgctga  4800
gtctgccag  gtgctgagg  gaagtgccc  cgccagcgt  gcgccctgg  gcggggtct  4860
caggacgag  atggctaca  gatgaagtt  gcctgctac  acccccgtg  ggagtacgg  4920
ttccaggtt  aggttctcc  agaagacag  agagctgct  tccgcctct  tgagaccaa  4980
atcacccaa  tcctgcact  caccaagga  gtcaaggcc  ctgctaatc  gatgcgcaa  5040
ttcctggtt  gagcctcct  ccgccttcg  ttggaacct  ggaaagaat  tttgatcat  5100
ggtctggat  gggccacct  tgacctcga  ggacacccc  agtacctgc  ggactcgaa  5160
agctggatc  aggagatgc  ctctgaacg  ctgtgccgg  gcacccgcc  gcgggcagc  5220
tgtgcccag  tcaacgact  cctccagga  tatggcact  aggggtgcc  ggtgtgagg  5280
ctgccctcc  acctccgct  ggaggaacc  gaacctggg  accatgaag  tggaagcac  5340
gctgtgtcc  ctttcatga  cacagcctg  gaccagggc  tattaaagg  ttttggcag  5400
aaagtgtca  tgttggc  5417



<210> 8560
<211> 1744
<212> PRT
<213> Homo sapiens
<308> P01028
<400> 8560

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
  1               5                  10                  15
Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
             20                  25                  30
Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
         35                  40                  45
Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
     50                  55                  60
Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
 65                  70                  75                  80
Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                 85                  90                  95
Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
             100                105                110
His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
         115                120                125
Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
     130                135                140
Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
 145                150                155                160
Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                 165                170                175
Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
             180                185                190
Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
         195                200                205
Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
     210                215                220
Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
 225                230                235                240
Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                 245                250                255
Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
             260                265                270
Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
         275                280                285
Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
     290                295                300
Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
 305                310                315                320
Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                 325                330                335
Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
             340                345                350
Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
         355                360                365
Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
     370                375                380
Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
 385                390                395                400
Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                 405                410                415
Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
             420                425                430
Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
         435                440                445
Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
     450                455                460
Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
 465                470                475                480
Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                 485                490                495
Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
             500                505                510
Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
         515                520                525
Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
     530                535                540
Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
 545                550                555                560
Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                 565                570                575
Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
             580                585                590
Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
         595                600                605
Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
     610                615                620
Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
 625                630                635                640
Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                 645                650                655
Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
             660                665                670
Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
         675                680                685
Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
     690                695                700
Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
 705                710                715                720
Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                 725                730                735
Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
             740                745                750
Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
         755                760                765
Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
     770                775                780
Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
 785                790                795                800
Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                 805                810                815
Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
             820                825                830
Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
         835                840                845
Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
     850                855                860
Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
 865                870                875                880
Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                 885                890                895
Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys 
             900                905                910
Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
         915                920                925
Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
     930                935                940
Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
 945                950                955                960
Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                 965                970                975
Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
             980                985                990
Gly Ala Leu Ser Pro Gly Gly Val Ala Ser Leu Leu Arg Leu Pro Arg 
         995                1000                1005
Gly Cys Gly Glu Gln Thr Met Ile Tyr Leu Ala Pro Thr Leu Ala Ala 
     1010                1015                1020
Ser Arg Tyr Leu Asp Lys Thr Glu Gln Trp Ser Thr Leu Pro Pro Glu 
 1025                1030                1035                1040
Thr Lys Asp His Ala Val Asp Leu Ile Gln Lys Gly Tyr Met Arg Ile 
                 1045                1050                1055
Gln Gln Phe Arg Lys Ala Asp Gly Ser Tyr Ala Ala Trp Leu Ser Arg 
             1060                1065                1070
Asp Ser Ser Thr Trp Leu Thr Ala Phe Val Leu Lys Val Leu Ser Leu 
         1075                1080                1085
Ala Gln Glu Gln Val Gly Gly Ser Pro Glu Lys Leu Gln Glu Thr Ser 
     1090                1095                1100
Asn Trp Leu Leu Ser Gln Gln Gln Ala Asp Gly Ser Phe Gln Asp Pro 
 1105                1110                1115                1120
Cys Pro Val Leu Asp Arg Ser Met Gln Gly Gly Leu Val Gly Asn Asp 
                 1125                1130                1135
Glu Thr Val Ala Leu Thr Ala Phe Val Thr Ile Ala Leu His His Gly 
             1140                1145                1150
Leu Ala Val Phe Gln Asp Glu Gly Ala Glu Pro Leu Lys Gln Arg Val 
         1155                1160                1165
Glu Ala Ser Ile Ser Lys Ala Asn Ser Phe Leu Gly Glu Lys Ala Ser 
     1170                1175                1180
Ala Gly Leu Leu Gly Ala His Ala Ala Ala Ile Thr Ala Tyr Ala Leu 
 1185                1190                1195                1200
Ser Leu Thr Lys Ala Pro Val Asp Leu Leu Gly Val Ala His Asn Asn 
                 1205                1210                1215
Leu Met Ala Met Ala Gln Glu Thr Gly Asp Asn Leu Tyr Trp Gly Ser 
             1220                1225                1230
Val Thr Gly Ser Gln Ser Asn Ala Val Ser Pro Thr Pro Ala Pro Arg 
         1235                1240                1245
Asn Pro Ser Asp Pro Met Pro Gln Ala Pro Ala Leu Trp Ile Glu Thr 
     1250                1255                1260
Thr Ala Tyr Ala Leu Leu His Leu Leu Leu His Glu Gly Lys Ala Glu 
 1265                1270                1275                1280
Met Ala Asp Gln Ala Ser Ala Trp Leu Thr Arg Gln Gly Ser Phe Gln 
                 1285                1290                1295
Gly Gly Phe Arg Ser Thr Gln Asp Thr Val Ile Ala Leu Asp Ala Leu 
             1300                1305                1310
Ser Ala Tyr Trp Ile Ala Ser His Thr Thr Glu Glu Arg Gly Leu Asn 
         1315                1320                1325
Val Thr Leu Ser Ser Thr Gly Arg Asn Gly Phe Lys Ser His Ala Leu 
     1330                1335                1340
Gln Leu Asn Asn Arg Gln Ile Arg Gly Leu Glu Glu Glu Leu Gln Phe 
 1345                1350                1355                1360
Ser Leu Gly Ser Lys Ile Asn Val Lys Val Gly Gly Asn Ser Lys Gly 
                 1365                1370                1375
Thr Leu Lys Val Leu Arg Thr Tyr Asn Val Leu Asp Met Lys Asn Thr 
             1380                1385                1390
Thr Cys Gln Asp Leu Gln Ile Glu Val Thr Val Lys Gly His Val Glu 
         1395                1400                1405
Tyr Thr Met Glu Ala Asn Glu Asp Tyr Glu Asp Tyr Glu Tyr Asp Glu 
     1410                1415                1420
Leu Pro Ala Lys Asp Asp Pro Asp Ala Pro Leu Gln Pro Val Thr Pro 
 1425                1430                1435                1440
Leu Gln Leu Phe Glu Gly Arg Arg Asn Arg Arg Arg Arg Glu Ala Pro 
                 1445                1450                1455
Lys Val Val Glu Glu Gln Glu Ser Arg Val His Tyr Thr Val Cys Ile 
             1460                1465                1470
Trp Arg Asn Gly Lys Val Gly Leu Ser Gly Met Ala Ile Ala Asp Val 
         1475                1480                1485
Thr Leu Leu Ser Gly Phe His Ala Leu Arg Ala Asp Leu Glu Lys Leu 
     1490                1495                1500
Thr Ser Leu Ser Asp Arg Tyr Val Ser His Phe Glu Thr Glu Gly Pro 
 1505                1510                1515                1520
His Val Leu Leu Tyr Phe Asp Ser Val Pro Thr Ser Arg Glu Cys Val 
                 1525                1530                1535
Gly Phe Glu Ala Val Gln Glu Val Pro Val Gly Leu Val Gln Pro Ala 
             1540                1545                1550
Ser Ala Thr Leu Tyr Asp Tyr Tyr Asn Pro Glu Arg Arg Cys Ser Val 
         1555                1560                1565
Phe Tyr Gly Ala Pro Ser Lys Ser Arg Leu Leu Ala Thr Leu Cys Ser 
     1570                1575                1580
Ala Glu Val Cys Gln Cys Ala Glu Gly Lys Cys Pro Arg Gln Arg Arg 
 1585                1590                1595                1600
Ala Leu Glu Arg Gly Leu Gln Asp Glu Asp Gly Tyr Arg Met Lys Phe 
                 1605                1610                1615
Ala Cys Tyr Tyr Pro Arg Val Glu Tyr Gly Phe Gln Val Lys Val Leu 
             1620                1625                1630
Arg Glu Asp Ser Arg Ala Ala Phe Arg Leu Phe Glu Thr Lys Ile Thr 
         1635                1640                1645
Gln Val Leu His Phe Thr Lys Asp Val Lys Ala Ala Ala Asn Gln Met 
     1650                1655                1660
Arg Asn Phe Leu Val Arg Ala Ser Cys Arg Leu Arg Leu Glu Pro Gly 
 1665                1670                1675                1680
Lys Glu Tyr Leu Ile Met Gly Leu Asp Gly Ala Thr Tyr Asp Leu Glu 
                 1685                1690                1695
Gly His Pro Gln Tyr Leu Leu Asp Ser Asn Ser Trp Ile Glu Glu Met 
             1700                1705                1710
Pro Ser Glu Arg Leu Cys Arg Ser Thr Arg Gln Arg Ala Ala Cys Ala 
         1715                1720                1725
Gln Leu Asn Asp Phe Leu Gln Glu Tyr Gly Thr Gln Gly Cys Gln Val 
     1730                1735                1740



<210> 8561
<211> 2461
<212> DNA
<213> Rattus norvegicus
<308> U42976
<400> 8561

ccgggacat  cgctcactc  cggttccat  gtagagtga  cggctgcca  ccggctggc  60
atgaggggt  cgcccctgc  cctcgtctc  ctgttctct  tgcttcagg  cggggactg  120
cgcctggcc  acgcagagg  gaagctgat  gatgacctc  tgaacaaaa  ccggtacaa  180
aacctgatc  gcccagcca  cagctcctc  cagctcatc  ccatccgcc  ggagctatc  240
ctgtcccag  tcatcagtg  gaatgagcg  gaacagatc  tgaccacca  catctggct  300
aaacaggaa  ggactgact  ccgcctggc  tggaacagc  cctgctatg  aggggtgaa  360
attctgagg  tccccgcaa  gcgtgtctg  ttgcctgac  tcgtgttgt  caacaatgc  420
gatggcacc  atgaggtgt  tgtctacac  aacgtgatt  tgcgttcca  cggcagcat  480
cagtggctg  cccctgcta  ctacaagag  gcctgcaag  ttgaggtga  gcactttcc  540
ttcgaccag  agaactgca  cctcaaatt  cgctcctgg  cctatgacc  cacggagat  600
gacatggtt  ttaagtcgc  cacggccat  atggatgac  tcaccccca  tggtgaatg  660
gacattgtg  ccctcccag  acggaggac  gtgaaccct  aggacccca  ctacgtgga  720
gtgacctat  acttcatca  caagcgcaa  ccgctcttc  acaccatca  tcttatcat  780
ccttgtgtg  tcatcacct  gctggctat  ctggtcttc  acctgccct  cgactgtgg  840
gagaagatg  cgctctgca  ctctgtgct  ctggcactc  cgttcttcc  gctgctcat  900
tccaagatc  tgcctccca  ctcccttga  ataccgctc  ttggcaagt  cctcttgtt  960
accatggtg  tggtcacct  ttccatcgt  accactgtg  gtgtcctca  tgtgcacca  1020
cgctcaccc  gcactcaca  catggcatc  tgggtcaag  agtgcttcc  gcacaaact  1080
cccaccttc  tcttcatga  gcgtcccgg  cttgaagtc  gcctggtca  ggtccctca  1140
cccagccag  tgcacttgg  cacagctga  actgcagcc  cctctgcct  aggccccac  1200
agcccatcc  acctctatg  gagttccat  tactttgtg  accctgtcc  tgccgctcc  1260
aagtctgca  tcagctccc  cacagcagg  ctccccagg  atgcccgtc  gaggtcctc  1320
gggaggttc  gggaagatc  acaggaagc  ttagagggt  tcagcttca  cgcccagca  1380
ctggagagc  atgaccgag  tcaaagtgt  atcgaggac  ggaagttcg  cgcgatggt  1440
gttgaccgc  tgttcctgt  ggtgttcgt  tttgtgtgt  ttctgggca  catggggct  1500
ttcctgcca  cccttttcc  gatccacgc  ccctccaag  actcctagg  tacccggcg  1560
gcctcgggc  cgggttgta  tgagatgat  tgagaagcc  tgtgggaag  tgggcgtgt  1620
ttggcccgg  ttgtagtga  atgatatga  aagccgtgt  ggaagctgg  cgtgtctcg  1680
gcccccggg  tgtagtgag  tgatatgag  agccgtgtg  gaagctgac  gttccattt  1740
ggccatagc  aatgaagcc  taagtaaag  cgtgactat  ggcaatcag  ccatcaaac  1800
agccacagc  acgagaagg  cagagatag  tgccttctg  tgatccctc  gatgccgtc  1860
agtaagtcc  tgaaggagg  ggatgaggc  gctgaatac  agcctggcc  ccttccttc  1920
acgtgccag  caccggagt  agacagccg  gtatcatgc  gtcacaccc  agcccgcct  1980
cccacccat  tccctctga  tcgcagcta  ccactagat  cccccacca  ctttcattt  2040
catacactt  tagattctc  caagtcaga  cctttatat  ttctactgc  accgtccaa  2100
cctcactgt  aactcccaa  cttttcacg  ggctgcacc  gtcagagct  tgctccaat  2160
ccacttcct  gtataagcc  tcccatgat  ctctgctcc  gtgtcattt  cttgtataa  2220
ccttcccta  tcatgcatt  caaagcagt  tctcccata  ccacatcaa  tctccagct  2280
ccttgagtg  tccccgtca  tagctgcag  ctttagttg  tggcacact  gtcaccagc  2340
ccttgccca  aaaagtgta  gctccataa  ggctgggtg  gtggattca  attcactcc  2400
gagcttggg  cccagctct  cacacagaa  gtgcaaaat  aatgtttat  gaatgaaaa  2460
a  2461



<210> 8562
<211> 495
<212> PRT
<213> Rattus norvegicus
<308> P12392
<400> 8562

Met Arg Gly Thr Pro Leu Leu Leu Val Ser Leu Phe Ser Leu Leu Gln 
  1               5                  10                  15
Asp Gly Asp Cys Arg Leu Ala Asn Ala Glu Glu Lys Leu Met Asp Asp 
             20                  25                  30
Leu Leu Asn Lys Thr Arg Tyr Asn Asn Leu Ile Arg Pro Ala Thr Ser 
         35                  40                  45
Ser Ser Gln Leu Ile Ser Ile Arg Leu Glu Leu Ser Leu Ser Gln Leu 
     50                  55                  60
Ile Ser Val Asn Glu Arg Glu Gln Ile Met Thr Thr Ser Ile Trp Leu 
 65                  70                  75                  80
Lys Gln Glu Trp Thr Asp Tyr Arg Leu Ala Trp Asn Ser Ser Cys Tyr 
                 85                  90                  95
Glu Gly Val Asn Ile Leu Arg Ile Pro Ala Lys Arg Val Trp Leu Pro 
             100                105                110
Asp Ile Val Leu Tyr Asn Asn Ala Asp Gly Thr Tyr Glu Val Ser Val 
         115                120                125
Tyr Thr Asn Val Ile Val Arg Ser Asn Gly Ser Ile Gln Trp Leu Pro 
     130                135                140
Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys His Phe Pro 
 145                150                155                160
Phe Asp Gln Gln Asn Cys Thr Leu Lys Phe Arg Ser Trp Thr Tyr Asp 
                 165                170                175
His Thr Glu Ile Asp Met Val Leu Lys Ser Pro Thr Ala Ile Met Asp 
             180                185                190
Asp Phe Thr Pro Ser Gly Glu Trp Asp Ile Val Ala Leu Pro Gly Arg 
         195                200                205
Arg Thr Val Asn Pro Gln Asp Pro Ser Tyr Val Asp Val Thr Tyr Asp 
     210                215                220
Phe Ile Ile Lys Arg Lys Pro Leu Phe Tyr Thr Ile Asn Leu Ile Ile 
 225                230                235                240
Pro Cys Val Leu Ile Thr Ser Leu Ala Ile Leu Val Phe Tyr Leu Pro 
                 245                250                255
Ser Asp Cys Gly Glu Lys Met Thr Leu Cys Ile Ser Val Leu Leu Ala 
             260                265                270
Leu Thr Phe Phe Leu Leu Leu Ile Ser Lys Ile Val Pro Pro Thr Ser 
         275                280                285
Leu Asp Ile Pro Leu Ile Gly Lys Tyr Leu Leu Phe Thr Met Val Leu 
     290                295                300
Val Thr Phe Ser Ile Val Thr Thr Val Cys Val Leu Asn Val His His 
 305                310                315                320
Arg Ser Pro Ser Thr His Thr Met Ala Ser Trp Val Lys Glu Cys Phe 
                 325                330                335
Leu His Lys Leu Pro Thr Phe Leu Phe Met Lys Arg Pro Gly Leu Glu 
             340                345                350
Val Ser Leu Val Arg Val Pro His Pro Ser Gln Leu His Leu Ala Thr 
         355                360                365
Ala Asp Thr Ala Ala Thr Ser Ala Leu Gly Pro Thr Ser Pro Ser Asn 
     370                375                380
Leu Tyr Gly Ser Ser Met Tyr Phe Val Asn Pro Val Pro Ala Ala Pro 
 385                390                395                400
Lys Ser Ala Val Ser Ser His Thr Ala Gly Leu Pro Arg Asp Ala Arg 
                 405                410                415
Leu Arg Ser Ser Gly Arg Phe Arg Glu Asp Leu Gln Glu Ala Leu Glu 
             420                425                430
Gly Val Ser Phe Ile Ala Gln His Leu Glu Ser Asp Asp Arg Asp Gln 
         435                440                445
Ser Val Ile Glu Asp Trp Lys Phe Val Ala Met Val Val Asp Arg Leu 
     450                455                460
Phe Leu Trp Val Phe Val Phe Val Cys Ile Leu Gly Thr Met Gly Leu 
 465                470                475                480
Phe Leu Pro Pro Leu Phe Gln Ile His Ala Pro Ser Lys Asp Ser 
                 485                490                495



<210> 8563
<211> 2455
<212> DNA
<213> Homo sapiens
<308> U48861
<400> 8563

ggcacgagc  gccagcaaa  ctcgggggc  aggaccggc  ctcactcga  cgcgcggct  60
acgggtgcc  tgtgacccc  cagcggacg  cgcggcggc  gccacccgg  cccgccggc  120
atgaggcgc  cgccttccc  ggtcctttt  ttcctggtc  ccctttgcg  gcgcgggaa  180
tgccgcgtg  ccaatgcgg  ggaaaagct  atggacgac  ttctgaaca  aacccgtta  240
aataacctg  tccgcccag  caccagctc  tcacagctc  tctccatca  gctgcagct  300
tccctggcc  agcttatca  cgtgaatga  cgagagcag  tcatgacca  caatgtctg  360
ctgaaacag  aatggactg  ttaccgcct  acctggaac  gctcccgct  cgagggtgt  420
aacatcctg  ggatccctg  aaagcgcat  tggttgcct  acatcgtgc  ttacaacaa  480
gccgacggg  cctatgagg  gtctgtcta  accaacttg  tagtccggt  caacggcag  540
gtcctgtgg  tgccccctg  catctacaa  agcgcctgc  agattgagg  gaagtactt  600
cccttcgac  agcagaact  caccctcaa  ttccgctcc  ggacctatg  ccacacgga  660
atagacatg  tcctcatga  gcccacagc  agcatggat  actttactc  cagtggtga  720
tgggacata  tggccctcc  agggagaag  acagtgaac  cacaagacc  cagctacgt  780
gacgtgact  acgacttca  catcaagcg  aagcctctg  tctacacca  caacctcat  840
atcccctgc  tgctcacca  cttgctggc  atcctcgtc  tctacctgc  atccgactg  900
ggcgagaag  tgacactgt  catctcagt  ctgctggca  tgacattct  cctgctgct  960
atctccaag  tcgtgccac  cacctccct  gatgtgcct  tcatcggca  gtacctcat  1020
ttcaccatg  tgctggtca  cttctccat  gtcaccagc  tctgtgtgc  caatgtgca  1080
caccgctcg  ccagcaccc  caccatggc  ccctgggtc  agcgctgct  cctgcacaa  1140
ctgcctacc  tcctcttca  gaagcgccc  ggccccgac  gcagcccgg  cagagcctt  1200
ccgcccagc  agtcatgcg  gaccaagcc  gaggccacc  ccacctcca  cagcccctc  1260
aacttctat  ggaactcca  gtactttgt  aaccccgcc  ctgcagctt  caagtctcc  1320
gccggctct  ccccggtgg  tatccccag  gatttctgg  tgcggtcct  tgggaggtt  1380
cgacaggat  tgcaggagg  attagaagg  gtcagcttc  tcgcccagc  catgaagaa  1440
gacgatgaa  accagagtg  cgttgagga  tggaagtac  tggctatgg  ggtggaccg  1500
ctgttcctg  gggtgttca  gtttgtgtg  gtcctgggc  ctgtggggc  cttcctacc  1560
cccctcttc  agacccatg  agcttctga  gggccctac  ctgcccagc  tgactgagg  1620
ccccctggg  tgtggggtg  gaggatgtg  gtggccggg  gggcacttt  ctgcttctt  1680
ctgggttgt  gccgatgag  cctaagtaa  tatgtgagc  ttggccatc  accccatca  1740
accagccca  gccgtggaa  aggcaagga  gggggcctg  gctgtcctc  ctgaatgcc  1800
tggagggat  ccaggaagc  ccagtagga  ggagcttca  acagttcaa  tctggcctg  1860
cttccttcc  tgcaccggg  aatggggat  aagatgact  cgtagcagc  cctactatg  1920
ttcaggcat  gtgccggcc  gcctctcca  caccatctc  ctccacttc  ccttgtcca  1980
ttcctcaca  acttctaga  tcttcccag  tcagaggct  ggcatttgc  atatcatca  2040
ctttttttt  ttcttttaa  cggagtctt  ctatatcgc  caggctcaa  tgattctcc  2100
gcctgaacc  cccaagtag  tgggattac  gaaagccgc  accgtgccc  gctaatttt  2160
gtatttttg  tggccaggc  gatttcgaa  tcctgacct  agatgaccc  cctgcctcg  2220
cctcccaaa  tgctgggat  acaggtgtg  gccactatg  ctggccttc  ctatcttct  2280
cctgaacct  cttcctctt  ccccagggc  tcccaagct  tttccacag  cacatcagt  2340
agggcatgg  tccaatcca  tctttgctc  aatgtcacc  cctctgaga  gccttccct  2400
accacccaa  cattctaaa  cagcctccc  acagtcacg  taccctgcc  ccttc  2455



<210> 8564
<211> 498
<212> PRT
<213> Homo sapiens
<308> P30926
<400> 8564

Met Arg Arg Ala Pro Ser Leu Val Leu Phe Phe Leu Val Ala Leu Cys 
  1               5                  10                  15
Gly Arg Gly Asn Cys Arg Val Ala Asn Ala Glu Glu Lys Leu Met Asp 
             20                  25                  30
Asp Leu Leu Asn Lys Thr Arg Tyr Asn Asn Leu Ile Arg Pro Ala Thr 
         35                  40                  45
Ser Ser Ser Gln Leu Ile Ser Ile Lys Leu Gln Leu Ser Leu Ala Gln 
     50                  55                  60
Leu Ile Ser Val Asn Glu Arg Glu Gln Ile Met Thr Thr Asn Val Trp 
 65                  70                  75                  80
Leu Lys Gln Glu Trp Thr Asp Tyr Arg Leu Thr Trp Asn Ser Ser Arg 
                 85                  90                  95
Tyr Glu Gly Val Asn Ile Leu Arg Ile Pro Ala Lys Arg Ile Trp Leu 
             100                105                110
Pro Asp Ile Val Leu Tyr Asn Asn Ala Asp Gly Thr Tyr Glu Val Ser 
         115                120                125
Val Tyr Thr Asn Leu Ile Val Arg Ser Asn Gly Ser Val Leu Trp Leu 
     130                135                140
Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys Tyr Phe 
 145                150                155                160
Pro Phe Asp Gln Gln Asn Cys Thr Leu Lys Phe Arg Ser Trp Thr Tyr 
                 165                170                175
Asp His Thr Glu Ile Asp Met Val Leu Met Thr Pro Thr Ala Ser Met 
             180                185                190
Asp Asp Phe Thr Pro Ser Gly Glu Trp Asp Ile Val Ala Leu Pro Gly 
         195                200                205
Arg Arg Thr Val Asn Pro Gln Asp Pro Ser Tyr Val Asp Val Thr Tyr 
     210                215                220
Asp Phe Ile Ile Lys Arg Lys Pro Leu Phe Tyr Thr Ile Asn Leu Ile 
 225                230                235                240
Ile Pro Cys Val Leu Thr Thr Leu Leu Ala Ile Leu Val Phe Tyr Leu 
                 245                250                255
Pro Ser Asp Cys Gly Glu Lys Met Thr Leu Cys Ile Ser Val Leu Leu 
             260                265                270
Ala Leu Thr Phe Phe Leu Leu Leu Ile Ser Lys Ile Val Pro Pro Thr 
         275                280                285
Ser Leu Asp Val Pro Leu Ile Gly Lys Tyr Leu Met Phe Thr Met Val 
     290                295                300
Leu Val Thr Phe Ser Ile Val Thr Ser Val Cys Val Leu Asn Val His 
 305                310                315                320
His Arg Ser Pro Ser Thr His Thr Met Ala Pro Trp Val Lys Arg Cys 
                 325                330                335
Phe Leu His Lys Leu Pro Thr Phe Leu Phe Met Lys Arg Pro Gly Pro 
             340                345                350
Asp Ser Ser Pro Ala Arg Ala Phe Pro Pro Ser Lys Ser Cys Val Thr 
         355                360                365
Lys Pro Glu Ala Thr Ala Thr Ser Thr Ser Pro Ser Asn Phe Tyr Gly 
     370                375                380
Asn Ser Met Tyr Phe Val Asn Pro Ala Ser Ala Ala Ser Lys Ser Pro 
 385                390                395                400
Ala Gly Ser Thr Pro Val Ala Ile Pro Arg Asp Phe Trp Leu Arg Ser 
                 405                410                415
Ser Gly Arg Phe Arg Gln Asp Val Gln Glu Ala Leu Glu Gly Val Ser 
             420                425                430
Phe Ile Ala Gln His Met Lys Asn Asp Asp Glu Asp Gln Ser Val Val 
         435                440                445
Glu Asp Trp Lys Tyr Val Ala Met Val Val Asp Arg Leu Phe Leu Trp 
     450                455                460
Val Phe Met Phe Val Cys Val Leu Gly Thr Val Gly Leu Phe Leu Pro 
 465                470                475                480
Pro Leu Phe Gln Thr His Ala Ala Ser Glu Gly Pro Tyr Ala Ala Gln 
                 485                490                495
Arg Asp 
             500



<210> 8565
<211> 847
<212> DNA
<213> Rattus norvegicus
<308> U44948
<400> 8565

acgagctag  cctccctag  tccgcccgc  gcgtgctcc  gcctcccac  cggaatgcc  60
gtctggggc  gtggaaata  gtgcggggc  tgcgggaga  ccgtgtacc  cgctgaaga  120
gtgcagtgt  atgggcgga  gttccaccg  tgctgcttt  tgtgcatgg  ttgcaggaa  180
aatttagac  gcacaacag  ggcaattca  gatgaagag  tctactgca  atcatgcta  240
ggaaagaag  atggaccaa  aggctatgg  tatggccag  gcgctggca  gctcaacat  300
gaccgtggt  agaggctgg  catcaagcc  gagagtgct  aacctcaca  gcctacaac  360
aatccaaac  cttctaaat  tgcccagaa  tatggaggt  ctgagaagt  ctccagatg  420
ggggattct  tgtatgctg  tgagaagat  attggagct  gaaagccct  gcacaaaaa  480
tgtttccga  gtgccaagt  tgggaagag  ctggagtct  caactctga  tgagaagga  540
ggtgaaatc  actgtaaag  gtgctacgc  aagaacttt  ggcccaagg  attcggcta  600
ggtcaagga  caggggccc  tgttcatgc  cagtagtgg  gtaaaccca  taagcatgg  660
aaagaacct  cattaatgt  gatggcctt  ccgcactca  gctgtgcat  ggccagcac  720
cagcactgt  tagcacaca  gctatgtgc  caatcgggc  ggacaggaa  cactacact  780
tcctgccca  ccgctaacg  ttaagaacg  tcttttaca  ttggaataa  attttggtt  840
gatttga  847



<210> 8566
<211> 192
<212> PRT
<213> Rattus norvegicus
<308> Q62908
<400> 8566

Pro Val Trp Gly Gly Gly Asn Lys Cys Gly Ala Cys Gly Arg Thr Val 
  1               5                  10                  15
Tyr His Ala Glu Glu Val Gln Cys Asp Gly Arg Thr Phe His Arg Cys 
             20                  25                  30
Cys Phe Leu Cys Met Val Cys Arg Lys Asn Leu Asp Ser Thr Thr Val 
         35                  40                  45
Ala Ile His Asp Glu Glu Ile Tyr Cys Lys Ser Cys Tyr Gly Lys Lys 
     50                  55                  60
Tyr Gly Pro Lys Gly Tyr Gly Tyr Gly Gln Gly Ala Gly Thr Leu Asn 
 65                  70                  75                  80
Met Asp Arg Gly Glu Arg Leu Gly Ile Lys Pro Glu Ser Ala Gln Pro 
                 85                  90                  95
His Arg Pro Thr Thr Asn Pro Asn Thr Ser Lys Phe Ala Gln Lys Tyr 
             100                105                110
Gly Gly Ala Glu Lys Cys Ser Arg Cys Gly Asp Ser Val Tyr Ala Ala 
         115                120                125
Glu Lys Ile Ile Gly Ala Gly Lys Pro Trp His Lys Asn Cys Phe Arg 
     130                135                140
Cys Ala Lys Cys Gly Lys Ser Leu Glu Ser Thr Thr Leu Thr Glu Lys 
 145                150                155                160
Glu Gly Glu Ile Tyr Cys Lys Gly Cys Tyr Ala Lys Asn Phe Gly Pro 
                 165                170                175
Lys Gly Phe Gly Tyr Gly Gln Gly Ala Gly Ala Leu Val His Ala Gln 
             180                185                190



<210> 8567
<211> 741
<212> DNA
<213> Homo sapiens
<308> U46006
<400> 8567

atgcctgtc  ggggaggtg  aaacaagtg  ggggcctgt  ggaggaccg  gtaccacgc  60
gaagaggtg  agtgtgatg  caggagctt  caccgctgc  gctttctct  catggtttg  120
aggaaaaat  tagatagca  aacagtggc  attcacgat  aagagatct  ctgcaaatc  180
tgctacgga  agaagtatg  gccaaaagg  tacggttat  gccagggcg  tggcacgct  240
aacatggac  gtggcgaga  gctgggcat  aaaccagag  gtgttcagc  tcacaggcc  300
acaacaaat  caaacactt  taaatttgc  cagaaatat  gaggtgctg  gaagtgttc  360
agatgtggg  attctgtat  tgctgccga  aagataatt  gagctggaa  gccctggca  420
aaaaactgt  tccgatgtg  aaagtgtgg  aagagtctt  aatcaacaa  tctgactga  480
aaagaaggt  aaatctatt  taaaggatg  tatgcaaag  actttgggc  caagggatt  540
ggctatggc  aaggagcag  ggctcttgt  catgcccag  aagatgtaa  ccctgaact  600
aacatcaca  actgagaat  tcttcataa  ctaggcaca  ataatcttt  acccggaat  660
ccgccgata  tgacgggct  caggagtcg  cgccaccaa  ccgaattcc  gcacactgg  720
ggccgttac  agtggatcc  a  741



<210> 8568
<211> 192
<212> PRT
<213> Homo sapiens
<308> Q16527
<400> 8568

Pro Val Trp Gly Gly Gly Asn Lys Cys Gly Ala Cys Gly Arg Thr Val 
  1               5                  10                  15
Tyr His Ala Glu Glu Val Gln Cys Asp Gly Arg Ser Phe His Arg Cys 
             20                  25                  30
Cys Phe Leu Cys Met Val Cys Arg Lys Asn Leu Asp Ser Thr Thr Val 
         35                  40                  45
Ala Ile His Asp Glu Glu Ile Tyr Cys Lys Ser Cys Tyr Gly Lys Lys 
     50                  55                  60
Tyr Gly Pro Lys Gly Tyr Gly Tyr Gly Gln Gly Ala Gly Thr Leu Asn 
 65                  70                  75                  80
Met Asp Arg Gly Glu Arg Leu Gly Ile Lys Pro Glu Ser Val Gln Pro 
                 85                  90                  95
His Arg Pro Thr Thr Asn Pro Asn Thr Ser Lys Phe Ala Gln Lys Tyr 
             100                105                110
Gly Gly Ala Glu Lys Cys Ser Arg Cys Gly Asp Ser Val Tyr Ala Ala 
         115                120                125
Glu Lys Ile Ile Gly Ala Gly Lys Pro Trp His Lys Asn Cys Phe Arg 
     130                135                140
Cys Ala Lys Cys Gly Lys Ser Leu Glu Ser Thr Thr Leu Thr Glu Lys 
 145                150                155                160
Glu Gly Glu Ile Tyr Cys Lys Gly Cys Tyr Ala Lys Asn Phe Gly Pro 
                 165                170                175
Lys Gly Phe Gly Tyr Gly Gln Gly Ala Gly Ala Leu Val His Ala Gln 
             180                185                190



<210> 8569
<211> 167
<212> DNA
<213> Rattus norvegicus
<308> U47316
<400> 8569

caggtcacg  aagccagtc  tgccggaga  accggcttc  gggaagccg  ccaggtctc  60
ttcctccct  ctgtttgga  gcagcatct  ctcttttta  ggagggccc  tcctttttt  120
ttacaaatt  ttcaataaa  acacattct  gaggcgaaa  aaaaaaa  167



<210> 8570
<211> 180
<212> PRT
<213> Rattus norvegicus
<308> AAH03736
<400> 8570

Met Ser Arg Gln Ala Asn Arg Gly Thr Glu Ser Lys Lys Met Ser Ser 
  1               5                  10                  15
Glu Leu Phe Thr Leu Thr Tyr Gly Ala Leu Val Thr Gln Leu Cys Lys 
             20                  25                  30
Asp Tyr Glu Asn Asp Glu Asp Val Asn Lys Gln Leu Asp Arg Met Gly 
         35                  40                  45
Tyr Asn Ile Gly Val Arg Leu Ile Glu Asp Phe Leu Ala Arg Ser Asn 
     50                  55                  60
Val Gly Arg Cys His Asp Phe Arg Glu Thr Ala Asp Val Ile Ala Lys 
 65                  70                  75                  80
Val Ala Phe Lys Met Tyr Leu Gly Ile Thr Pro Ser Ile Thr Asn Trp 
                 85                  90                  95
Ser Pro Ala Gly Asp Glu Phe Ser Leu Ile Leu Glu Asn Asn Pro Leu 
             100                105                110
Val Asp Phe Val Glu Leu Pro Asp Asn His Ser Ala Leu Ile Tyr Ser 
         115                120                125
Asn Leu Leu Cys Gly Val Leu Arg Gly Ala Leu Glu Met Val Gln Met 
     130                135                140
Ala Val Glu Ala Lys Phe Val Gln Asp Thr Leu Lys Gly Asp Gly Val 
 145                150                155                160
Thr Glu Ile Arg Met Arg Phe Ile Arg Arg Ile Glu Asp Asn Leu Pro 
                 165                170                175
Ala Gly Glu Glu 
             180



<210> 8571
<211> 805
<212> DNA
<213> Homo sapiens
<308> AF041432
<400> 8571

tgggctgag  ggcagcggc  taggctccg  cgtctgcag  ggtcgccga  ctaacccgt  60
gctaggcga  tggggcggg  cggccggca  catgtcgag  caggcgaac  gtggcaccg  120
gagcaagaa  atgagctct  agctcttca  cctgaccta  ggtgccctg  tcacccagc  180
atgtaagga  tatgaaaat  atgaagatg  gaataaaca  ctggacaaa  tgggcttta  240
cattggagt  cggctgatt  aagatttct  ggctcggtc  aatgttggg  ggtgccatg  300
ctttcggga  actgcggat  tcattgcca  ggtggcgtt  aagatgtac  tgggcatca  360
tccaagcat  actaattgg  gcccagctg  tgatgaatt  tccctcatt  tggaaaata  420
ccccttggt  gactttgtg  aacttcctg  taaccactc  tcccttatt  attccaatc  480
cttgtgtgg  gtgttgcgg  gagctttgg  gatggtcca  atggctgtg  aggccaagt  540
tgtccagga  accctgaaa  gagacggtg  gacagaaat  cggatgaga  tcatcaggc  600
gattgagga  aatcttcca  ctggagagg  ataaccatc  ctacaactc  aggatagcc  660
tcaggagca  tgttggaat  agcaggcct  tgtgctccc  ctgccctcc  gaactcagt  720
actcttgaa  atggatgtt  tatattctt  taacctgtt  ccattctcc  ttcaaataa  780
gagcagact  cgatatagt  cattt  805



<210> 8572
<211> 180
<212> PRT
<213> Homo sapiens
<308> O43617
<400> 8572

Met Ser Arg Gln Ala Asn Arg Gly Thr Glu Ser Lys Lys Met Ser Ser 
  1               5                  10                  15
Glu Leu Phe Thr Leu Thr Tyr Gly Ala Leu Val Thr Gln Leu Cys Lys 
             20                  25                  30
Asp Tyr Glu Asn Asp Glu Asp Val Asn Lys Gln Leu Asp Lys Met Gly 
         35                  40                  45
Phe Asn Ile Gly Val Arg Leu Ile Glu Asp Phe Leu Ala Arg Ser Asn 
     50                  55                  60
Val Gly Arg Cys His Asp Phe Arg Glu Thr Ala Asp Val Ile Ala Lys 
 65                  70                  75                  80
Val Ala Phe Lys Met Tyr Leu Gly Ile Thr Pro Ser Ile Thr Asn Trp 
                 85                  90                  95
Ser Pro Ala Gly Asp Glu Phe Ser Leu Ile Leu Glu Asn Asn Pro Leu 
             100                105                110
Val Asp Phe Val Glu Leu Pro Asp Asn His Ser Ser Leu Ile Tyr Ser 
         115                120                125
Asn Leu Leu Cys Gly Val Leu Arg Gly Ala Leu Glu Met Val Gln Met 
     130                135                140
Ala Val Glu Ala Lys Phe Val Gln Asp Thr Leu Lys Gly Asp Gly Val 
 145                150                155                160
Thr Glu Ile Arg Met Arg Phe Ile Arg Arg Ile Glu Asp Asn Leu Pro 
                 165                170                175
Ala Gly Glu Glu 
             180



<210> 8573
<211> 2915
<212> DNA
<213> Rattus norvegicus
<308> U48246
<400> 8573

aagcactgg  ttcttgtta  cgttggtgc  ccctgcttg  cgggggttc  ccggagcga  60
gccgatgga  gtgatttta  ttttgtggt  ctgtgtatg  accgccagg  cagtgttgg  120
ctttgggat  gaccctgac  ttcagctgg  catcatctc  gagctcgac  tggtgaaca  180
caccctggg  gtcacgcag  tggctggac  gcacaacgc  agtaaagca  ttctatttc  240
agatgtaca  agagagatc  attcggccc  tcacgtgag  gagaagctg  tccagctat  300
ccggaataa  agcgagttc  cctttttgg  tacagtgca  cagaaacca  ccacctcag  360
ggtgatact  tccatccgg  agctggagc  cagctattt  gaactggag  gcagtggcc  420
aagagaaga  atacgctac  attacatac  tggtggaaa  cccaggact  aggcccttc  480
ctaccgcat  gcagacgga  aatggcaca  ggtcgcgct  tcagtgagc  cctctcacc  540
cctgctcca  atcgactgc  ataggattt  cgagcgtgt  atagaccct  cggagacca  600
ccttcctcc  ggaagcaat  tgtggcttg  gcaacgtaa  caaaagcat  gctttttca  660
aggaatcat  caagatggt  agatcatct  catgccgaa  ggtttcatc  cacagtgtc  720
caacctcaa  cgcacttgc  caacatgca  tgacttcct  agcctggtt  aaggaataa  780
ggatttgca  gagcttttg  ccaagatga  tgcaaaact  aattatgca  agacgagac  840
tggtcaact  gaaaattgc  actgtgaga  gacctgcca  gtgagtggg  tgctctaca  900
ggaccaaga  tcctgggtg  atggtgaca  ctgtgggaa  tgcacgtgc  aaagtggtg  960
cgtggagtg  cgcaggatg  cctgtcccc  gctcaactg  tccccggac  cacttcctg  1020
gcacatttc  ggccagtgt  gtaaagttt  cagaccaaa  tgtatctat  gaggaaaag  1080
tcttgctga  ggccagcgg  ttttaacca  gacctgccg  gaatgtcga  gtggagtct  1140
ggtaaaaat  acagaagct  gccctcctt  gaactgctc  gcaaaggat  atattcttc  1200
agagaatca  tgctgcagg  tctgcccag  tcataactt  tgtgcagaa  cacctaagt  1260
cggagaaaa  tcggaatgc  aaaattgga  tacaaaagc  acctgtgag  gcaagaatg  1320
atacatctc  gtccagggc  actctgcat  ctgtgaaga  attgatgag  gtgcagcta  1380
aatgcacta  tgtcatgcc  acaccgtgt  tgtcaactt  ccggggttg  atcgctgtg  1440
ctgcgtccc  gggtacatc  gtgtggatg  cttctcttg  acggagcat  atgattgtg  1500
cagcggaca  cacaactgc  acaaaaatg  catctgtac  aacacagtc  agggacaca  1560
ctgcacctg  cagccgggt  acgtgggaa  tggcaccat  tgcaaagca  tctgtgaag  1620
gggttgcag  tacggaggt  cctgtgtgg  tcctaacaa  tgtgtctgt  cttctggat  1680
cacgggaag  cactgtgag  aagatattg  tgaatgcgc  gagggattc  ttgaatgcc  1740
caactactc  cgctgtgtt  acctgccag  gtggtacca  tgtgagtgc  gaagcggtt  1800
ccatgacga  gggacctac  cactgtccg  ggagtcctg  attgatatc  atgaatgtg  1860
cttaagaac  cacacttgt  ggaatgact  tgcctgcat  aacttagca  gaggatttg  1920
ctgcctgtg  ccctctggg  cctcctgct  tggtgactg  ccccacgaa  gagggctga  1980
gcataatgg  caggtgtgg  ttctgagag  agacaggtg  tcagtctgt  cctgcaagg  2040
tgggaagat  ttctgccgg  ggacagctt  tgattgcca  aatccaaat  ttgaccttt  2100
ttgctgccc  gagtgcgat  ccagggtca  cagccaatg  ttagatcaa  gtggacaga  2160
gctctatcg  agtggagac  actggaccc  cagctgcca  cagtgccga  gtctggaag  2220
agaggcaga  tgctggcct  tggcttgcc  tagtttggg  tgtgaatac  cagccatgt  2280
tgaagggga  tgttgtccc  gatgtgtca  tgacccctg  ctggctggt  atattgcct  2340
tgacatcag  aaaacttgc  tggacagct  tggtgtttc  aggctgagc  gagccgtgt  2400
gacaatggc  ggatctcct  gtacaacct  caaatgcaa  aatgggaga  tctgctgct  2460
tgtggatct  gagtgtatt  agaataact  aagatttta  atggactcg  cacgtgaga  2520
aatgggcaa  atgatcatc  cacctgagg  agaagaggg  ctgatttct  tttcttttt  2580
accacagtc  attaccaaa  tctccatct  aggaaggcg  ttggattgc  tttgccact  2640
tgctcatcc  tgctgacct  gtctagatg  ctgcagtac  gtgcatttc  gtcgatggt  2700
gttgagtct  agtgttgta  atcgcattt  cctcgtcag  tcatttaca  atacattta  2760
aggggttcc  tgataaatg  taatgtaac  tttgtttat  ttgtgtact  acataatag  2820
gacttggca  catttattt  tttttcttg  tttttggat  aaattctaa  aataaagtt  2880
cctgttgcg  aaaaaaaaa  aaaaaaaaa  aaaaa  2915



<210> 8574
<211> 810
<212> PRT
<213> Rattus norvegicus
<308> Q62919
<400> 8574

Met Pro Met Asp Val Ile Leu Val Leu Trp Phe Cys Val Cys Thr Ala 
  1               5                  10                  15
Arg Thr Val Leu Gly Phe Gly Met Asp Pro Asp Leu Gln Leu Asp Ile 
             20                  25                  30
Ile Ser Glu Leu Asp Leu Val Asn Thr Thr Leu Gly Val Thr Gln Val 
         35                  40                  45
Ala Gly Leu His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Val Gln 
     50                  55                  60
Arg Glu Ile His Ser Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu 
 65                  70                  75                  80
Phe Arg Asn Lys Ser Glu Phe Thr Phe Leu Ala Thr Val Gln Gln Lys 
                 85                  90                  95
Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser 
             100                105                110
Tyr Phe Glu Leu Glu Ser Ser Gly Pro Arg Glu Glu Ile Arg Tyr His 
         115                120                125
Tyr Ile His Gly Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met 
     130                135                140
Ala Asp Gly Gln Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His 
 145                150                155                160
Leu Leu Leu His Ile Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp 
                 165                170                175
Pro Pro Glu Thr Asn Leu Pro Pro Gly Ser Asn Leu Trp Leu Gly Gln 
             180                185                190
Arg Asn Gln Lys His Gly Phe Phe Lys Gly Ile Ile Gln Asp Gly Lys 
         195                200                205
Ile Ile Phe Met Pro Asn Gly Phe Ile Thr Gln Cys Pro Asn Leu Asn 
     210                215                220
Arg Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile 
 225                230                235                240
Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr 
                 245                250                255
Ala Glu Thr Arg Leu Gly Gln Leu Glu Asn Cys His Cys Glu Lys Thr 
             260                265                270
Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp 
         275                280                285
Gly Asp Asn Cys Gly Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys 
     290                295                300
Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro 
 305                310                315                320
Val His Ile Ser Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile 
                 325                330                335
Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Thr 
             340                345                350
Cys Arg Glu Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Ala Cys 
         355                360                365
Pro Pro Leu Asn Cys Ser Ala Lys Asp His Ile Leu Pro Glu Asn Gln 
     370                375                380
Cys Cys Arg Val Cys Pro Gly His Asn Phe Cys Ala Glu Ala Pro Lys 
 385                390                395                400
Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys 
                 405                410                415
Glu Cys Lys Asn Gly Tyr Ile Ser Val Gln Gly Asn Ser Ala Tyr Cys 
             420                425                430
Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn 
         435                440                445
Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro 
     450                455                460
Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Asp Cys 
 465                470                475                480
Gly Ser Gly Gln His Asn Cys Asp Lys Asn Ala Ile Cys Thr Asn Thr 
                 485                490                495
Val Gln Gly His Ser Cys Thr Cys Gln Pro Gly Tyr Val Gly Asn Gly 
             500                505                510
Thr Ile Cys Lys Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr 
         515                520                525
Cys Val Ala Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser 
     530                535                540
His Cys Glu Lys Asp Ile Asp Glu Cys Ala Glu Gly Phe Val Glu Cys 
 545                550                555                560
His Asn Tyr Ser Arg Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu 
                 565                570                575
Cys Arg Ser Gly Phe His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu 
             580                585                590
Ser Cys Ile Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp 
         595                600                605
Asn Asp Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys 
     610                615                620
Pro Ser Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu 
 625                630                635                640
Lys His Asn Gly Gln Val Trp Ile Leu Arg Glu Asp Arg Cys Ser Val 
                 645                650                655
Cys Ser Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp 
             660                665                670
Cys Gln Asn Pro Asn Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr 
         675                680                685
Arg Val Thr Ser Gln Cys Leu Asp Gln Ser Gly Gln Lys Leu Tyr Arg 
     690                695                700
Ser Gly Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu 
 705                710                715                720
Gly Glu Ala Asp Cys Trp Pro Leu Ala Cys Pro Ser Leu Gly Cys Glu 
                 725                730                735
Tyr Thr Ala Met Phe Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp 
             740                745                750
Pro Cys Leu Ala Gly Asn Ile Ala Tyr Asp Ile Arg Lys Thr Cys Leu 
         755                760                765
Asp Ser Phe Gly Val Ser Arg Leu Ser Gly Ala Val Trp Thr Met Ala 
     770                775                780
Gly Ser Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Arg Val Cys Cys 
 785                790                795                800
Ser Val Asp Leu Glu Cys Ile Glu Asn Asn 
                 805                810



<210> 8575
<211> 1722
<212> DNA
<213> Homo sapiens
<308> U57523
<400> 8575

gatcagtgc  gccgtgtct  tagaggtca  aacttttgt  cagaaggac  taaatgtgg  60
gaaaactca  agtgcaaaa  ctggaatac  aaagctact  gtgagtgca  gagtggtta  120
atctctgtc  aggggagac  ctgcctact  tgaagatat  gatgagtgt  cagctaaga  180
gcattactg  catgccaat  ctgtgtgtg  caaccttcc  gggttatat  gctgtgact  240
tgtcccagg  tacattcgt  tggatgact  ctcttgtac  gaacacgat  aatgtggca  300
cggccagca  aactgtgat  agaatgcca  ctgcaccaa  actgtccag  gacacagct  360
cacctgcaa  ccgggctac  tggggaacg  gaccatctg  agagctttc  gtgaagagg  420
ctgcagata  ggtggaacg  gtgtggctc  caacaaatg  gtctgtcca  ctggattca  480
aggaagcca  tgcgagaaa  atattgatg  atgttcaga  ggaatcatt  agtgccaca  540
ccattcccg  tgcgttaac  tgccagggt  gcaccactg  gagtgcaga  gcggtttcc  600
tgacgatgg  acctattca  tgtccgggg  gtcctgtat  gacattgat  aatgtgcct  660
aagaactca  acctgttgg  acgattctg  ctgcatcaa  ctggcaggg  gttttgact  720
tctctgccc  tgtgggccc  cctgctctg  tgactgtcc  catgaaggg  ggctgaagc  780
caatggcca  gtgtggacc  tgaaagaag  caggtgttc  gtctgctcc  gcaaggatg  840
taagatatt  tgccgacgg  cagcttgtg  ttgccagaa  ccaagtgct  acctattct  900
ttgcccaga  tgtgacacc  gagtcacaa  tcaatgttt  gaccaaaat  gtcacaagc  960
gtatcgaag  ggagacaat  ggacccata  ctgtcagca  tgtcggtgt  tggaaggag  1020
ggtagattg  tggccactc  cttgcccca  cttgagctg  gagtataca  ctatcttag  1080
aggggaatg  tgtccccgc  gtgtcagtg  cccctgcct  gctgataac  tcacctatg  1140
catcagaaa  acttgcctg  acagtatgg  gtttcacgg  ttagtggct  agtgtggac  1200
atggctgga  ctccctgca  aacctgtaa  tgcaagaat  gaagagtct  ttgttctgt  1260
gattttgag  gtcttcaaa  taattgaag  atttacagt  gactcaacg  agaagaatg  1320
acgaaatga  catccaacg  gattaagga  aggaatcgg  agtttggtt  ttttgtttg  1380
tttgttttt  taaccacag  taattgcca  agtttccac  tgaggacgg  gtttggagg  1440
tgccttttg  acctaccac  ttgctcatt  ttgctaacc  agtttaggt  acctacagt  1500
ccgtgcatt  aagtcagtg  ttgttaaaa  aagtttccc  cgttgtaaa  catgtttcc  1560
ttatcagat  atttgcaaa  acatttaaa  gatntcatg  taaatgttg  tgtattttt  1620
ggtttattt  ctgtactaa  ataatagag  gagantnag  tccttttat  tattttgtt  1680
atttatgga  caaattnta  aataaagtt  cctgttgtg  aa  1722



<210> 8576
<211> 810
<212> PRT
<213> Homo sapiens
<308> Q92832
<400> 8576

Met Pro Met Asp Leu Ile Leu Val Val Trp Phe Cys Val Cys Thr Ala 
  1               5                  10                  15
Arg Thr Val Val Gly Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile 
             20                  25                  30
Val Thr Glu Leu Asp Leu Val Asn Thr Thr Leu Gly Val Ala Gln Val 
         35                  40                  45
Ser Gly Met His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Ile Glu 
     50                  55                  60
Arg Glu Ile His Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu 
 65                  70                  75                  80
Phe Gln Asn Lys Ser Glu Phe Thr Ile Leu Ala Thr Val Gln Gln Lys 
                 85                  90                  95
Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser 
             100                105                110
Tyr Phe Glu Leu Glu Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His 
         115                120                125
Tyr Ile His Asn Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met 
     130                135                140
Ala Asp Gly Gln Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His 
 145                150                155                160
Leu Leu Leu His Val Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp 
                 165                170                175
Pro Pro Asp Thr Asn Leu Pro Pro Gly Ile Asn Leu Trp Leu Gly Gln 
             180                185                190
Arg Asn Gln Lys His Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys 
         195                200                205
Ile Ile Phe Met Pro Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn 
     210                215                220
His Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile 
 225                230                235                240
Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr 
                 245                250                255
Ala Glu Thr Arg Leu Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr 
             260                265                270
Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp 
         275                280                285
Gly Asp His Cys Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys 
     290                295                300
Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro 
 305                310                315                320
Val His Ile Ala Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile 
                 325                330                335
Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser 
             340                345                350
Cys Arg Glu Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Met Cys 
         355                360                365
Pro Pro Leu Asn Cys Ser Glu Lys Asp His Ile Leu Pro Glu Asn Gln 
     370                375                380
Cys Cys Arg Val Cys Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys 
 385                390                395                400
Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys 
                 405                410                415
Glu Cys Lys Ser Gly Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys 
             420                425                430
Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn 
         435                440                445
Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro 
     450                455                460
Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys 
 465                470                475                480
Gly Ser Gly Gln His Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr 
                 485                490                495
Val Gln Gly His Ser Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly 
             500                505                510
Thr Ile Cys Arg Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr 
         515                520                525
Cys Val Ala Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser 
     530                535                540
His Cys Glu Lys Asp Ile Asp Glu Cys Ser Glu Gly Ile Ile Glu Cys 
 545                550                555                560
His Asn His Ser Arg Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu 
                 565                570                575
Cys Arg Ser Gly Phe His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu 
             580                585                590
Ser Cys Ile Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp 
         595                600                605
Asn Asp Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys 
     610                615                620
Pro Ser Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu 
 625                630                635                640
Lys His Asn Gly Gln Val Trp Thr Leu Lys Glu Asp Arg Cys Ser Val 
                 645                650                655
Cys Ser Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp 
             660                665                670
Cys Gln Asn Pro Ser Ala Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr 
         675                680                685
Arg Val Thr Ser Gln Cys Leu Asp Gln Asn Gly His Lys Leu Tyr Arg 
     690                695                700
Ser Gly Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu 
 705                710                715                720
Gly Glu Val Asp Cys Trp Pro Leu Thr Cys Pro Asn Leu Ser Cys Glu 
                 725                730                735
Tyr Thr Ala Ile Leu Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp 
             740                745                750
Pro Cys Leu Ala Asp Asn Ile Thr Tyr Asp Ile Arg Lys Thr Cys Leu 
         755                760                765
Asp Ser Tyr Gly Val Ser Arg Leu Ser Gly Ser Val Trp Thr Met Ala 
     770                775                780
Gly Ser Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Arg Val Cys Cys 
 785                790                795                800
Ser Val Asp Phe Glu Cys Leu Gln Asn Asn 
                 805                810



<210> 8577
<211> 2915
<212> DNA
<213> Rattus norvegicus
<308> U48246
<400> 8577

aagcactgg  ttcttgtta  cgttggtgc  ccctgcttg  cgggggttc  ccggagcga  60
gccgatgga  gtgatttta  ttttgtggt  ctgtgtatg  accgccagg  cagtgttgg  120
ctttgggat  gaccctgac  ttcagctgg  catcatctc  gagctcgac  tggtgaaca  180
caccctggg  gtcacgcag  tggctggac  gcacaacgc  agtaaagca  ttctatttc  240
agatgtaca  agagagatc  attcggccc  tcacgtgag  gagaagctg  tccagctat  300
ccggaataa  agcgagttc  cctttttgg  tacagtgca  cagaaacca  ccacctcag  360
ggtgatact  tccatccgg  agctggagc  cagctattt  gaactggag  gcagtggcc  420
aagagaaga  atacgctac  attacatac  tggtggaaa  cccaggact  aggcccttc  480
ctaccgcat  gcagacgga  aatggcaca  ggtcgcgct  tcagtgagc  cctctcacc  540
cctgctcca  atcgactgc  ataggattt  cgagcgtgt  atagaccct  cggagacca  600
ccttcctcc  ggaagcaat  tgtggcttg  gcaacgtaa  caaaagcat  gctttttca  660
aggaatcat  caagatggt  agatcatct  catgccgaa  ggtttcatc  cacagtgtc  720
caacctcaa  cgcacttgc  caacatgca  tgacttcct  agcctggtt  aaggaataa  780
ggatttgca  gagcttttg  ccaagatga  tgcaaaact  aattatgca  agacgagac  840
tggtcaact  gaaaattgc  actgtgaga  gacctgcca  gtgagtggg  tgctctaca  900
ggaccaaga  tcctgggtg  atggtgaca  ctgtgggaa  tgcacgtgc  aaagtggtg  960
cgtggagtg  cgcaggatg  cctgtcccc  gctcaactg  tccccggac  cacttcctg  1020
gcacatttc  ggccagtgt  gtaaagttt  cagaccaaa  tgtatctat  gaggaaaag  1080
tcttgctga  ggccagcgg  ttttaacca  gacctgccg  gaatgtcga  gtggagtct  1140
ggtaaaaat  acagaagct  gccctcctt  gaactgctc  gcaaaggat  atattcttc  1200
agagaatca  tgctgcagg  tctgcccag  tcataactt  tgtgcagaa  cacctaagt  1260
cggagaaaa  tcggaatgc  aaaattgga  tacaaaagc  acctgtgag  gcaagaatg  1320
atacatctc  gtccagggc  actctgcat  ctgtgaaga  attgatgag  gtgcagcta  1380
aatgcacta  tgtcatgcc  acaccgtgt  tgtcaactt  ccggggttg  atcgctgtg  1440
ctgcgtccc  gggtacatc  gtgtggatg  cttctcttg  acggagcat  atgattgtg  1500
cagcggaca  cacaactgc  acaaaaatg  catctgtac  aacacagtc  agggacaca  1560
ctgcacctg  cagccgggt  acgtgggaa  tggcaccat  tgcaaagca  tctgtgaag  1620
gggttgcag  tacggaggt  cctgtgtgg  tcctaacaa  tgtgtctgt  cttctggat  1680
cacgggaag  cactgtgag  aagatattg  tgaatgcgc  gagggattc  ttgaatgcc  1740
caactactc  cgctgtgtt  acctgccag  gtggtacca  tgtgagtgc  gaagcggtt  1800
ccatgacga  gggacctac  cactgtccg  ggagtcctg  attgatatc  atgaatgtg  1860
cttaagaac  cacacttgt  ggaatgact  tgcctgcat  aacttagca  gaggatttg  1920
ctgcctgtg  ccctctggg  cctcctgct  tggtgactg  ccccacgaa  gagggctga  1980
gcataatgg  caggtgtgg  ttctgagag  agacaggtg  tcagtctgt  cctgcaagg  2040
tgggaagat  ttctgccgg  ggacagctt  tgattgcca  aatccaaat  ttgaccttt  2100
ttgctgccc  gagtgcgat  ccagggtca  cagccaatg  ttagatcaa  gtggacaga  2160
gctctatcg  agtggagac  actggaccc  cagctgcca  cagtgccga  gtctggaag  2220
agaggcaga  tgctggcct  tggcttgcc  tagtttggg  tgtgaatac  cagccatgt  2280
tgaagggga  tgttgtccc  gatgtgtca  tgacccctg  ctggctggt  atattgcct  2340
tgacatcag  aaaacttgc  tggacagct  tggtgtttc  aggctgagc  gagccgtgt  2400
gacaatggc  ggatctcct  gtacaacct  caaatgcaa  aatgggaga  tctgctgct  2460
tgtggatct  gagtgtatt  agaataact  aagatttta  atggactcg  cacgtgaga  2520
aatgggcaa  atgatcatc  cacctgagg  agaagaggg  ctgatttct  tttcttttt  2580
accacagtc  attaccaaa  tctccatct  aggaaggcg  ttggattgc  tttgccact  2640
tgctcatcc  tgctgacct  gtctagatg  ctgcagtac  gtgcatttc  gtcgatggt  2700
gttgagtct  agtgttgta  atcgcattt  cctcgtcag  tcatttaca  atacattta  2760
aggggttcc  tgataaatg  taatgtaac  tttgtttat  ttgtgtact  acataatag  2820
gacttggca  catttattt  tttttcttg  tttttggat  aaattctaa  aataaagtt  2880
cctgttgcg  aaaaaaaaa  aaaaaaaaa  aaaaa  2915



<210> 8578
<211> 810
<212> PRT
<213> Rattus norvegicus
<308> Q62919
<400> 8578

Met Pro Met Asp Val Ile Leu Val Leu Trp Phe Cys Val Cys Thr Ala 
  1               5                  10                  15
Arg Thr Val Leu Gly Phe Gly Met Asp Pro Asp Leu Gln Leu Asp Ile 
             20                  25                  30
Ile Ser Glu Leu Asp Leu Val Asn Thr Thr Leu Gly Val Thr Gln Val 
         35                  40                  45
Ala Gly Leu His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Val Gln 
     50                  55                  60
Arg Glu Ile His Ser Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu 
 65                  70                  75                  80
Phe Arg Asn Lys Ser Glu Phe Thr Phe Leu Ala Thr Val Gln Gln Lys 
                 85                  90                  95
Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser 
             100                105                110
Tyr Phe Glu Leu Glu Ser Ser Gly Pro Arg Glu Glu Ile Arg Tyr His 
         115                120                125
Tyr Ile His Gly Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met 
     130                135                140
Ala Asp Gly Gln Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His 
 145                150                155                160
Leu Leu Leu His Ile Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp 
                 165                170                175
Pro Pro Glu Thr Asn Leu Pro Pro Gly Ser Asn Leu Trp Leu Gly Gln 
             180                185                190
Arg Asn Gln Lys His Gly Phe Phe Lys Gly Ile Ile Gln Asp Gly Lys 
         195                200                205
Ile Ile Phe Met Pro Asn Gly Phe Ile Thr Gln Cys Pro Asn Leu Asn 
     210                215                220
Arg Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile 
 225                230                235                240
Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr 
                 245                250                255
Ala Glu Thr Arg Leu Gly Gln Leu Glu Asn Cys His Cys Glu Lys Thr 
             260                265                270
Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp 
         275                280                285
Gly Asp Asn Cys Gly Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys 
     290                295                300
Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro 
 305                310                315                320
Val His Ile Ser Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile 
                 325                330                335
Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Thr 
             340                345                350
Cys Arg Glu Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Ala Cys 
         355                360                365
Pro Pro Leu Asn Cys Ser Ala Lys Asp His Ile Leu Pro Glu Asn Gln 
     370                375                380
Cys Cys Arg Val Cys Pro Gly His Asn Phe Cys Ala Glu Ala Pro Lys 
 385                390                395                400
Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys 
                 405                410                415
Glu Cys Lys Asn Gly Tyr Ile Ser Val Gln Gly Asn Ser Ala Tyr Cys 
             420                425                430
Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn 
         435                440                445
Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro 
     450                455                460
Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Asp Cys 
 465                470                475                480
Gly Ser Gly Gln His Asn Cys Asp Lys Asn Ala Ile Cys Thr Asn Thr 
                 485                490                495
Val Gln Gly His Ser Cys Thr Cys Gln Pro Gly Tyr Val Gly Asn Gly 
             500                505                510
Thr Ile Cys Lys Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr 
         515                520                525
Cys Val Ala Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser 
     530                535                540
His Cys Glu Lys Asp Ile Asp Glu Cys Ala Glu Gly Phe Val Glu Cys 
 545                550                555                560
His Asn Tyr Ser Arg Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu 
                 565                570                575
Cys Arg Ser Gly Phe His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu 
             580                585                590
Ser Cys Ile Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp 
         595                600                605
Asn Asp Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys 
     610                615                620
Pro Ser Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu 
 625                630                635                640
Lys His Asn Gly Gln Val Trp Ile Leu Arg Glu Asp Arg Cys Ser Val 
                 645                650                655
Cys Ser Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp 
             660                665                670
Cys Gln Asn Pro Asn Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr 
         675                680                685
Arg Val Thr Ser Gln Cys Leu Asp Gln Ser Gly Gln Lys Leu Tyr Arg 
     690                695                700
Ser Gly Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu 
 705                710                715                720
Gly Glu Ala Asp Cys Trp Pro Leu Ala Cys Pro Ser Leu Gly Cys Glu 
                 725                730                735
Tyr Thr Ala Met Phe Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp 
             740                745                750
Pro Cys Leu Ala Gly Asn Ile Ala Tyr Asp Ile Arg Lys Thr Cys Leu 
         755                760                765
Asp Ser Phe Gly Val Ser Arg Leu Ser Gly Ala Val Trp Thr Met Ala 
     770                775                780
Gly Ser Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Arg Val Cys Cys 
 785                790                795                800
Ser Val Asp Leu Glu Cys Ile Glu Asn Asn 
                 805                810



<210> 8579
<211> 1722
<212> DNA
<213> Homo sapiens
<308> U57523
<400> 8579

gatcagtgc  gccgtgtct  tagaggtca  aacttttgt  cagaaggac  taaatgtgg  60
gaaaactca  agtgcaaaa  ctggaatac  aaagctact  gtgagtgca  gagtggtta  120
atctctgtc  aggggagac  ctgcctact  tgaagatat  gatgagtgt  cagctaaga  180
gcattactg  catgccaat  ctgtgtgtg  caaccttcc  gggttatat  gctgtgact  240
tgtcccagg  tacattcgt  tggatgact  ctcttgtac  gaacacgat  aatgtggca  300
cggccagca  aactgtgat  agaatgcca  ctgcaccaa  actgtccag  gacacagct  360
cacctgcaa  ccgggctac  tggggaacg  gaccatctg  agagctttc  gtgaagagg  420
ctgcagata  ggtggaacg  gtgtggctc  caacaaatg  gtctgtcca  ctggattca  480
aggaagcca  tgcgagaaa  atattgatg  atgttcaga  ggaatcatt  agtgccaca  540
ccattcccg  tgcgttaac  tgccagggt  gcaccactg  gagtgcaga  gcggtttcc  600
tgacgatgg  acctattca  tgtccgggg  gtcctgtat  gacattgat  aatgtgcct  660
aagaactca  acctgttgg  acgattctg  ctgcatcaa  ctggcaggg  gttttgact  720
tctctgccc  tgtgggccc  cctgctctg  tgactgtcc  catgaaggg  ggctgaagc  780
caatggcca  gtgtggacc  tgaaagaag  caggtgttc  gtctgctcc  gcaaggatg  840
taagatatt  tgccgacgg  cagcttgtg  ttgccagaa  ccaagtgct  acctattct  900
ttgcccaga  tgtgacacc  gagtcacaa  tcaatgttt  gaccaaaat  gtcacaagc  960
gtatcgaag  ggagacaat  ggacccata  ctgtcagca  tgtcggtgt  tggaaggag  1020
ggtagattg  tggccactc  cttgcccca  cttgagctg  gagtataca  ctatcttag  1080
aggggaatg  tgtccccgc  gtgtcagtg  cccctgcct  gctgataac  tcacctatg  1140
catcagaaa  acttgcctg  acagtatgg  gtttcacgg  ttagtggct  agtgtggac  1200
atggctgga  ctccctgca  aacctgtaa  tgcaagaat  gaagagtct  ttgttctgt  1260
gattttgag  gtcttcaaa  taattgaag  atttacagt  gactcaacg  agaagaatg  1320
acgaaatga  catccaacg  gattaagga  aggaatcgg  agtttggtt  ttttgtttg  1380
tttgttttt  taaccacag  taattgcca  agtttccac  tgaggacgg  gtttggagg  1440
tgccttttg  acctaccac  ttgctcatt  ttgctaacc  agtttaggt  acctacagt  1500
ccgtgcatt  aagtcagtg  ttgttaaaa  aagtttccc  cgttgtaaa  catgtttcc  1560
ttatcagat  atttgcaaa  acatttaaa  gatntcatg  taaatgttg  tgtattttt  1620
ggtttattt  ctgtactaa  ataatagag  gagantnag  tccttttat  tattttgtt  1680
atttatgga  caaattnta  aataaagtt  cctgttgtg  aa  1722



<210> 8580
<211> 810
<212> PRT
<213> Homo sapiens
<308> Q92832
<400> 8580

Met Pro Met Asp Leu Ile Leu Val Val Trp Phe Cys Val Cys Thr Ala 
  1               5                  10                  15
Arg Thr Val Val Gly Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile 
             20                  25                  30
Val Thr Glu Leu Asp Leu Val Asn Thr Thr Leu Gly Val Ala Gln Val 
         35                  40                  45
Ser Gly Met His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Ile Glu 
     50                  55                  60
Arg Glu Ile His Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu 
 65                  70                  75                  80
Phe Gln Asn Lys Ser Glu Phe Thr Ile Leu Ala Thr Val Gln Gln Lys 
                 85                  90                  95
Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser 
             100                105                110
Tyr Phe Glu Leu Glu Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His 
         115                120                125
Tyr Ile His Asn Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met 
     130                135                140
Ala Asp Gly Gln Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His 
 145                150                155                160
Leu Leu Leu His Val Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp 
                 165                170                175
Pro Pro Asp Thr Asn Leu Pro Pro Gly Ile Asn Leu Trp Leu Gly Gln 
             180                185                190
Arg Asn Gln Lys His Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys 
         195                200                205
Ile Ile Phe Met Pro Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn 
     210                215                220
His Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile 
 225                230                235                240
Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr 
                 245                250                255
Ala Glu Thr Arg Leu Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr 
             260                265                270
Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp 
         275                280                285
Gly Asp His Cys Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys 
     290                295                300
Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro 
 305                310                315                320
Val His Ile Ala Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile 
                 325                330                335
Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser 
             340                345                350
Cys Arg Glu Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Met Cys 
         355                360                365
Pro Pro Leu Asn Cys Ser Glu Lys Asp His Ile Leu Pro Glu Asn Gln 
     370                375                380
Cys Cys Arg Val Cys Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys 
 385                390                395                400
Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys 
                 405                410                415
Glu Cys Lys Ser Gly Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys 
             420                425                430
Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn 
         435                440                445
Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro 
     450                455                460
Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys 
 465                470                475                480
Gly Ser Gly Gln His Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr 
                 485                490                495
Val Gln Gly His Ser Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly 
             500                505                510
Thr Ile Cys Arg Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr 
         515                520                525
Cys Val Ala Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser 
     530                535                540
His Cys Glu Lys Asp Ile Asp Glu Cys Ser Glu Gly Ile Ile Glu Cys 
 545                550                555                560
His Asn His Ser Arg Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu 
                 565                570                575
Cys Arg Ser Gly Phe His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu 
             580                585                590
Ser Cys Ile Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp 
         595                600                605
Asn Asp Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys 
     610                615                620
Pro Ser Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu 
 625                630                635                640
Lys His Asn Gly Gln Val Trp Thr Leu Lys Glu Asp Arg Cys Ser Val 
                 645                650                655
Cys Ser Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp 
             660                665                670
Cys Gln Asn Pro Ser Ala Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr 
         675                680                685
Arg Val Thr Ser Gln Cys Leu Asp Gln Asn Gly His Lys Leu Tyr Arg 
     690                695                700
Ser Gly Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu 
 705                710                715                720
Gly Glu Val Asp Cys Trp Pro Leu Thr Cys Pro Asn Leu Ser Cys Glu 
                 725                730                735
Tyr Thr Ala Ile Leu Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp 
             740                745                750
Pro Cys Leu Ala Asp Asn Ile Thr Tyr Asp Ile Arg Lys Thr Cys Leu 
         755                760                765
Asp Ser Tyr Gly Val Ser Arg Leu Ser Gly Ser Val Trp Thr Met Ala 
     770                775                780
Gly Ser Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Arg Val Cys Cys 
 785                790                795                800
Ser Val Asp Phe Glu Cys Leu Gln Asn Asn 
                 805                810



<210> 8581
<211> 1862
<212> DNA
<213> Rattus norvegicus
<308> U48592
<400> 8581

tcctgggtt  cgcttggac  agggcgctg  aggaggcag  ggccggcca  cccgcaccc  60
tctggtcgc  gtcgccgag  ctgcttggc  ggcccagta  ggatgggac  tccttggtg  120
ttgatgagt  tgttcttct  tgggatcct  cagagtcac  cttccgaac  ctgtgatga  180
tggggacta  ataccatgc  acaaatcca  gtgtttgaa  atgagccag  tcgcatcaa  240
tgccccctc  ttgaacact  cttgaagta  aactacagc  ctgcccatt  ctctggact  300
accctgatc  ggtactgga  caggcaaga  cgggacctg  aggagccca  taatttccg  360
cttccagag  atcgcatca  taaggagaa  gatgtgctc  ggttccggc  caccctcct  420
aatgacacg  gcaattaca  ctgcatgtt  aggaacacg  cttactgca  caaagttgc  480
tttcccctg  aagttgttc  gaaggacag  tgtttcaat  cccccatga  actcccagt  540
cacaggctg  atattgaac  gggtattca  aatatcacg  gtccaaatg  agatggata  600
tttccttcc  gtgtcaaac  atcggtcac  tggtataag  gttgtactg  aatagtgaa  660
tttcataat  ttcaaccca  gggcatgaa  ttgagtttt  tcatcccct  ggtatcaaa  720
aacggaaat  acacatgtg  ggtgacgta  ctggaaaac  gacggctct  tcacctcac  780
aggactatg  ctgtaaagg  ggtaggctc  ccaaaggat  cagtaccac  tcatatcta  840
tcgccaaat  accgcgttg  ctatgagaa  gaaccagga  aggagttgg  tattccctg  900
aaagtctat  tcagtttca  tatggactc  cacaatgag  tctggtgga  cattgatgg  960
aagaagcct  atgacgtcc  tgttgacat  actattatt  aaagcgtaa  ttattcttc  1020
acggaagat  agacaagga  tcagatttt  agcatcaag  aagtcaccc  tgaggatct  1080
aagcgcaac  atgtctgtc  cgctcgaaa  gccgaaggg  aagccgagc  agcagccaa  1140
gtgaaacag  aagtcatac  gccaaggta  acagtagaa  tcgcctgtg  ttttggagc  1200
acagtcttt  tggtggtgg  tctcatcgt  gtttaccac  tttactggc  ggagatggt  1260
ctcttttac  gggctcatt  tggaacgga  gaaacaatt  ttgacggaa  agaatatga  1320
atttatgtt  cctatgcaa  aaatgcaga  gaagaagag  ttgtgctgc  gacactacg  1380
ggagttttg  agaatgagt  cggatacaa  ctgtgcatc  tcgacaggg  cagcttccc  1440
gggggaatt  tcacagatg  gaccctgag  ttcattcag  aaagcagac  actcctggt  1500
gtcctaagc  ccaactacg  gctccaggg  acacaagcc  tcctggagc  caaggctgg  1560
ctagaaaat  tggcctccc  gggcaacat  aacgtcatt  tagtgcagt  caaagctgt  1620
aaggacttg  aggtgaaag  gctgaagcg  gctaagtcg  tgctcaccg  cattaaatg  1680
aaaggggag  aatccaagt  tcctcaggg  aggttctgg  agcagctgc  ggtggccat  1740
ccagtgaag  agagtccca  gtggtctag  agtgacaag  agggtctct  ctactcatc  1800
ctgaaaaac  tatgaaagg  aaagtcagg  ggtgaaaag  acaaggcgg  tcatgggag  1860
aa  1862



<210> 8582
<211> 570
<212> PRT
<213> Rattus norvegicus
<308> AAB03502
<400> 8582

Met Gly Leu Pro Trp Cys Leu Met Ser Leu Phe Phe Cys Gly Ile Leu 
  1               5                  10                  15
Gln Ser His Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
             20                  25                  30
Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
         35                  40                  45
Leu Phe Glu His Phe Leu Lys Tyr Asn Tyr Ser Thr Ala His Ser Ser 
     50                  55                  60
Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
 65                  70                  75                  80
Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                 85                  90                  95
Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
             100                105                110
Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
         115                120                125
Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Arg Leu 
     130                135                140
Pro Val His Arg Leu Tyr Ile Glu Gln Gly Ile His Asn Ile Thr Cys 
 145                150                155                160
Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Ser Val Thr 
                 165                170                175
Trp Tyr Lys Gly Cys Thr Glu Ile Val Asn Phe His Asn Val Gln Pro 
             180                185                190
Lys Gly Met Asn Leu Ser Phe Phe Ile Pro Leu Val Ser Asn Asn Gly 
         195                200                205
Asn Tyr Thr Cys Val Val Thr Tyr Leu Glu Asn Gly Arg Leu Phe His 
     210                215                220
Leu Thr Arg Thr Met Thr Val Lys Val Val Gly Ser Pro Lys Asp Ala 
 225                230                235                240
Val Pro Pro His Ile Tyr Ser Pro Asn Asp Arg Val Val Tyr Glu Lys 
                 245                250                255
Glu Pro Gly Glu Glu Leu Val Ile Pro Cys Lys Val Tyr Phe Ser Phe 
             260                265                270
Ile Met Asp Ser His Asn Glu Ile Trp Trp Thr Ile Asp Gly Lys Lys 
         275                280                285
Pro Asp Asp Val Pro Val Asp Ile Thr Ile Ile Glu Ser Val Ser Tyr 
     290                295                300
Ser Ser Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
 305                310                315                320
Val Thr Pro Glu Asp Leu Lys Arg Asn Tyr Val Cys His Ala Arg Asn 
                 325                330                335
Ala Glu Gly Glu Ala Glu Gln Ala Ala Lys Val Lys Gln Lys Val Ile 
             340                345                350
Pro Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
         355                360                365
Phe Leu Val Val Val Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
     370                375                380
Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
 385                390                395                400
Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                 405                410                415
Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
             420                425                430
Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Phe Pro Gly Gly 
         435                440                445
Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
     450                455                460
Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
 465                470                475                480
Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                 485                490                495
Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Asp Leu Lys Val Lys 
             500                505                510
Glu Leu Lys Arg Ala Lys Ser Val Leu Thr Val Ile Lys Trp Lys Gly 
         515                520                525
Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
     530                535                540
Ala Met Pro Val Lys Lys Ser Pro Arg Trp Ser Ser Ser Asp Lys Gln 
 545                550                555                560
Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                 565                570



<210> 8584
<211> 570
<212> PRT
<213> Homo sapiens
<308> NP_002173
<400> 8584

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
  1               5                  10                  15
Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
             20                  25                  30
Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
         35                  40                  45
Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
     50                  55                  60
Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
 65                  70                  75                  80
Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                 85                  90                  95
Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
             100                105                110
Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
         115                120                125
Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
     130                135                140
Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
 145                150                155                160
Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                 165                170                175
Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
             180                185                190
Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
         195                200                205
Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
     210                215                220
Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
 225                230                235                240
Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                 245                250                255
Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
             260                265                270
Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
         275                280                285
Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
     290                295                300
Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
 305                310                315                320
Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                 325                330                335
Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
             340                345                350
Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
         355                360                365
Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
     370                375                380
Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
 385                390                395                400
Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                 405                410                415
Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
             420                425                430
Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
         435                440                445
Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
     450                455                460
Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
 465                470                475                480
Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                 485                490                495
Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
             500                505                510
Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
         515                520                525
Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
     530                535                540
Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
 545                550                555                560
Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                 565                570



<210> 8585
<211> 5180
<212> DNA
<213> Rattus norvegicus
<308> U48596
<400> 8585

gaattccgc  cccggggcg  gacaagagg  ctgctttcc  aagagaagg  ttcgcgtct  60
tctgcagca  gcgacagtc  cgggcgcca  ctgcgcttc  ggcgcgggc  aggctggtg  120
gcgccgggc  cccagcgcc  gctactgag  gcgtgaagt  accgaccgt  agtcctccg  180
cttgcgtcc  cttccagca  cagggactc  cgccccaat  actgcttgc  caagggtgg  240
cgagctccg  ccgagccgc  gccccgccc  gtactacct  gcagctgcc  gggtgcagc  300
cacagcgcc  cgcgcggcc  cagcagagc  cctgccctc  cacctgcgc  gcgcgcccg  360
cgctccgtg  tcccgagac  ggagacgcg  ccccgctcc  gctcgcgcc  gcgcactcg  420
cgcagcgcg  gcgcccgcc  ctccgcccg  cccccgcgc  ctccccgcc  cctccctcc  480
ccgcaggca  gagcgaatg  agcccgcga  agaaaatgg  ggcggcggc  ggcgatcgc  540
cctcgtcgt  gggattccc  ggcgccgcg  cggcgagcc  cgaggcggg  ggcggcggc  600
gagctctcc  gggaagcgg  gcgcccgca  cgggcgcgg  gctgctgcg  gagactggc  660
gcgcgggcc  cgagcgcgc  gactggcgg  ggcagcagc  gcgcaaagt  aggagtgtg  720
agctggacc  gctgccgga  cagccgctc  tcctcaccg  ctcgccgcc  tgcccatct  780
cttccccgt  gccggagcc  gcggacgcg  ctgcaggag  gagtggctt  cagcctgcg  840
cgggaccgc  acccccggg  gcagcgagt  gctgcggct  ccactctgc  gagctggcg  900
ccgcgcggg  cagcggcgc  cggagcccc  cgggggccg  gccgccctc  gcagcggcc  960
cctccggtc  agagatgga  aataaagaa  ccctcaaag  attgcacaa  atggatgac  1020
gcccagagg  gcgaatgat  agggagaag  tcaaggcga  ctgtatgcc  gcctggaag  1080
acgagtggt  agaaaggag  aacaggaga  gccctgtgg  ggtgaaacc  atccctatt  1140
aaggagatg  atctgaaat  agtaacttg  cagctgagc  ccaaggaga  ggccaggca  1200
gctctgctg  accagctcc  aagggccga  gaagcccgt  tcctggaag  tccccatca  1260
ggcgctcag  gaagccgga  tccccagga  tgagacgga  acgagtgtc  ccagtgcct  1320
tccagagtg  cagaatcac  ccacctcga  gagccccgt  gccagatgg  ttctcaccg  1380
acagcccag  ggagacgag  cgccgtgtg  acaaagtga  gagggccag  ctgtacctc  1440
tgcagcaga  aggacccaa  tctttcctg  ttggaggag  cagtccaga  aataaatac  1500
gcgtgttta  tgggccaca  aactgcagc  gtgggcgtg  gacattctg  attcacctc  1560
tgtttgtca  gctccgggt  ttccagcta  aaccctccg  ccccatgct  tggagaaaa  1620
ctttaaaaa  ttttgaggt  gagagtttg  tccagaaat  ccacagtag  cgtagctca  1680
gaatcaaag  tccatctcg  aacaccatc  agaagtttg  ctcacgcat  tcaaactgt  1740
acacattgt  atcgtctag  acatccaca  ctagttcag  aaacagcat  aaggatgaa  1800
aggagcaga  gtgtcccat  tgcttgttg  gcatgctgg  tgaggagag  ctgactgtg  1860
gtgaagacg  ctgcaggaa  aagctgcac  accactgca  gtcaatctg  gcagaagaa  1920
gtagaagaa  tagagaacc  ttaatatgt  ccctttgta  atctaagtg  agatcccat  1980
acttctaca  ccatgagtt  tcaagccct  tggattccc  tacctccct  cgaggtgta  2040
agcagccct  ctccccgca  cagcctgtg  ccggatcac  gcggaggaa  caggaaagc  2100
attttaacc  tactcatta  ggaacccag  agattcctc  cgcttacaa  gatttagcc  2160
agccatgga  tcaggcatt  ggaatggag  tcgttggct  cttattctc  agaaactgg  2220
acgtaaggg  gatggccct  aggcgcctt  cccacgatg  tagcggggc  ctgttgttg  2280
cgaacgggg  gagcactgg  acttctgga  gcggcagcg  aggcagcct  agtgctggc  2340
ccgccagtg  gtcttccca  cccagcatc  caggggacg  ggtggaggc  ttctgcagc  2400
tcctgtcta  cgtgtgcgc  gaccctgtc  acaaagtgt  cgttgctgc  ttaaaaaca  2460
tgagagcca  gctggtata  actccttgc  acagcctgg  agaaagaat  aaacttcag  2520
gacttctcc  gccagtggt  gacaccatc  tagtgaagt  cgcagacgc  aatagccgc  2580
cgagtcagc  gtccatatc  acactgttg  agctctgca  gggccaagc  ggggagttg  2640
cagttggac  agaaatact  aaagctgga  ccatcggtg  tggtggcgt  gattacgtc  2700
taagttgta  tcttggaaa  caagctgaa  caaacaact  gcaagaact  ctgggtcgc  2760
tctgtctta  agacagatt  ctcttggaa  tttctgcgg  attttatcc  catattgtc  2820
gtaccgatg  ctcacaagc  gagcctgtt  aaatcaggt  taagaagct  ctgtccctc  2880
tagcctttg  cttgcaatc  attgacaat  cccactcta  ggtcggcaa  ctctcgcgg  2940
ggatttatc  gagctcagc  cgaatggtg  ccacagtgc  ccccctgtt  tccaagctg  3000
taaccatgc  aagtgcttc  ggatcctcc  acttcgcca  gatgcgccg  cgtctgatg  3060
ccattgcag  cgaggtaga  attgccgag  tcatccagc  gggttcgga  gacactttg  3120
atggccagc  ggacagctc  caggcattg  cccctcccc  ctatccaga  agcagctcc  3180
ttgagcaca  agcccatgt  gagaaaact  gaaaaggat  aaaagctac  agactgagt  3240
ccagctcag  ggacatttc  gacagactg  ctggcgttt  tgtaggact  cctagttca  3300
caacaacag  acaaccaaa  ccaacagtt  aaacaaaag  cagacccca  agtcagtgt  3360
tgaactcct  tcctttgtc  cctcctcag  taatgtttc  agcaatatc  gccccatgt  3420
catctgccc  gtctgtccc  gctggctct  taacagatg  ttctaagca  agacctcgg  3480
cgtttgttc  ctgtaaaat  ccctctgcg  ctccccaaa  acagcgcaa  ttttcccta  3540
agttccaga  gacctgctc  gagaaccga  actcagaaa  actctcccc  gtctttact  3600
agtcgagac  cccaccctc  agtaacata  acagggcaa  ggcatcccg  cccgttccg  3660
gtagcacaa  caaactagg  gatgcctca  aaaacagca  gacactcga  ctgaacagt  3720
cttcccagt  tgatgacag  tttggcagt  gcagcaaca  tggcagcgc  gtcataccc  3780
gtgaggaga  ggcattcac  ccagcagag  acaagtgca  gttagatgt  aaccccgag  3840
tcaactcca  tatcgagga  cttcttgaa  catctatgc  ttcaagtga  acaacagtc  3900
ctttcaagt  cgaagtcgc  gtcctctct  ctgagaagg  cgaaagtga  gacacctac  3960
aagatgacg  caatcacaa  caaaagtgc  aagagaaga  ggaggctga  gaagaggag  4020
cgctcgcga  tgccatggc  atgtcggct  ctcaggacg  cctccccat  gtccctcag  4080
tgcaggtgg  aaatggaga  gatatcatc  tcatccagc  ggatacacc  gaaacccta  4140
cagggcata  caaagcgaa  gagccctac  gagaagaca  cgagtggct  aaagggcag  4200
agataggcc  cggagcatt  tcttcttgt  accaagcac  ggatgtggg  actggaact  4260
taatggctg  gaaacaggt  acctacgtc  gaaacacat  ttctgagca  gaggaagtg  4320
tggaagcct  gagggaaga  atcaggatg  tgagccacc  caaccatcc  aacatcatc  4380
ggatgctgg  ggccacgtg  gagaagagc  actacaacc  cttcatcga  tggatggcg  4440
gagcctccg  ggctcacct  ttgagtaaa  atggagctt  caaggagtc  gtggtcatt  4500
actacacag  gcagttact  cgtggcctt  cctatctcc  cgagaacca  atcattcac  4560
gagacgtca  aggggccaa  ctgctcatt  acagcaccg  tcagcggct  agaattgca  4620
acttcggtg  tgccgccag  ttggcatcc  aaggaactg  tgcaggaga  ttccaggga  4680
agttactgg  gacaattgc  ttcatggcg  ctgaggtac  aagaggtca  cagtacggt  4740
ggagctgtg  cgtctggag  gttggctgc  ccattatag  aatggcctg  gcaaaacca  4800
cctggaacg  agaaaagca  tccaatcat  ttgctttga  atttaagat  gcgagtgca  4860
ctactgcac  atccatccc  tcacacctg  ccccgggcc  gcgagacgt  gctctgcgc  4920
gtttagaac  tcaacctca  gacagacct  cgtcaagag  gctactgaa  catcctgtc  4980
tccgtacaa  atggtagtc  actgctcag  gtgcgcaac  aggaaagaa  actcgcggg  5040
agccacgtt  atagtctgc  ggcctcata  cactgacca  aagaggggc  agtggggag  5100
ccgcaccta  gcatgtgac  gacaaatca  gactgcacc  gagctccgt  tgcagacgg  5160
tacaactcg  gcaggagctg  5180



<210> 8586
<211> 1493
<212> PRT
<213> Rattus norvegicus
<308> Q62925
<400> 8586

Met Ala Ala Ala Ala Gly Asp Arg Ala Ser Ser Ser Gly Phe Pro Gly 
  1               5                  10                  15
Ala Ala Ala Ala Ser Pro Glu Ala Gly Gly Gly Gly Gly Ala Leu Gln 
             20                  25                  30
Gly Ser Gly Ala Pro Ala Ala Gly Ala Gly Leu Leu Arg Glu Thr Gly 
         35                  40                  45
Ser Ala Gly Arg Glu Arg Ala Asp Trp Arg Arg Gln Gln Leu Arg Lys 
     50                  55                  60
Val Arg Ser Val Glu Leu Asp Gln Leu Pro Glu Gln Pro Leu Phe Leu 
 65                  70                  75                  80
Thr Ala Ser Pro Pro Cys Pro Ser Thr Ser Pro Ser Pro Glu Pro Ala 
                 85                  90                  95
Asp Ala Ala Ala Gly Ala Ser Gly Phe Gln Pro Ala Ala Gly Pro Pro 
             100                105                110
Pro Pro Gly Ala Ala Ser Arg Cys Gly Ser His Ser Ala Glu Leu Ala 
         115                120                125
Ala Ala Arg Asp Ser Gly Ala Arg Ser Pro Ala Gly Ala Glu Pro Pro 
     130                135                140
Ser Ala Ala Ala Pro Ser Gly Arg Glu Met Glu Asn Lys Glu Thr Leu 
 145                150                155                160
Lys Gly Leu His Lys Met Asp Asp Arg Pro Glu Glu Arg Met Ile Arg 
                 165                170                175
Glu Lys Leu Lys Ala Thr Cys Met Pro Ala Trp Lys His Glu Trp Leu 
             180                185                190
Glu Arg Arg Asn Arg Arg Gly Pro Val Val Val Lys Pro Ile Pro Ile 
         195                200                205
Lys Gly Asp Gly Ser Glu Met Ser Asn Leu Ala Ala Glu Leu Gln Gly 
     210                215                220
Glu Gly Gln Ala Gly Ser Ala Ala Pro Ala Pro Lys Gly Arg Arg Ser 
 225                230                235                240
Pro Ser Pro Gly Ser Ser Pro Ser Gly Arg Ser Gly Lys Pro Glu Ser 
                 245                250                255
Pro Gly Val Arg Arg Lys Arg Val Ser Pro Val Pro Phe Gln Ser Gly 
             260                265                270
Arg Ile Thr Pro Pro Arg Arg Ala Pro Ser Pro Asp Gly Phe Ser Pro 
         275                280                285
Tyr Ser Pro Glu Glu Thr Ser Arg Arg Val Asn Lys Val Met Arg Ala 
     290                295                300
Arg Leu Tyr Leu Leu Gln Gln Ile Gly Pro Asn Ser Phe Leu Ile Gly 
 305                310                315                320
Gly Asp Ser Pro Asp Asn Lys Tyr Arg Val Phe Ile Gly Pro Gln Asn 
                 325                330                335
Cys Ser Cys Gly Arg Gly Thr Phe Cys Ile His Leu Leu Phe Val Met 
             340                345                350
Leu Arg Val Phe Gln Leu Glu Pro Ser Asp Pro Met Leu Trp Arg Lys 
         355                360                365
Thr Leu Lys Asn Phe Glu Val Glu Ser Leu Phe Gln Lys Tyr His Ser 
     370                375                380
Arg Arg Ser Ser Arg Ile Lys Ala Pro Ser Arg Asn Thr Ile Gln Lys 
 385                390                395                400
Phe Val Ser Arg Met Ser Asn Cys His Thr Leu Ser Ser Ser Ser Thr 
                 405                410                415
Ser Thr Ser Ser Ser Glu Asn Ser Ile Lys Asp Glu Glu Glu Gln Met 
             420                425                430
Cys Pro Ile Cys Leu Leu Gly Met Leu Asp Glu Glu Ser Leu Thr Val 
         435                440                445
Cys Glu Asp Gly Cys Arg Asn Lys Leu His His His Cys Met Ser Ile 
     450                455                460
Trp Ala Glu Glu Cys Arg Arg Asn Arg Glu Pro Leu Ile Cys Pro Leu 
 465                470                475                480
Cys Arg Ser Lys Trp Arg Ser His Asp Phe Tyr Ser His Glu Leu Ser 
                 485                490                495
Ser Pro Val Asp Ser Pro Thr Ser Leu Arg Gly Val Gln Gln Pro Ser 
             500                505                510
Ser Pro Gln Gln Pro Val Ala Gly Ser Gln Arg Arg Asn Gln Glu Ser 
         515                520                525
Asn Phe Asn Leu Thr His Tyr Gly Thr Gln Gln Ile Pro Pro Ala Tyr 
     530                535                540
Lys Asp Leu Ala Glu Pro Trp Ile Gln Ala Phe Gly Met Glu Leu Val 
 545                550                555                560
Gly Cys Leu Phe Ser Arg Asn Trp Asn Val Arg Glu Met Ala Leu Arg 
                 565                570                575
Arg Leu Ser His Asp Val Ser Gly Ala Leu Leu Leu Ala Asn Gly Glu 
             580                585                590
Ser Thr Gly Thr Ser Gly Gly Gly Ser Gly Gly Ser Leu Ser Ala Gly 
         595                600                605
Ala Ala Ser Gly Ser Ser Gln Pro Ser Ile Ser Gly Asp Val Val Glu 
     610                615                620
Ala Phe Cys Ser Val Leu Ser Ile Val Cys Ala Asp Pro Val Tyr Lys 
 625                630                635                640
Val Tyr Val Ala Ala Leu Lys Thr Leu Arg Ala Met Leu Val Tyr Thr 
                 645                650                655
Pro Cys His Ser Leu Ala Glu Arg Ile Lys Leu Gln Arg Leu Leu Arg 
             660                665                670
Pro Val Val Asp Thr Ile Leu Val Lys Cys Ala Asp Ala Asn Ser Arg 
         675                680                685
Thr Ser Gln Leu Ser Ile Ser Thr Leu Leu Glu Leu Cys Lys Gly Gln 
     690                695                700
Ala Gly Glu Leu Ala Val Gly Arg Glu Ile Leu Lys Ala Gly Ser Ile 
 705                710                715                720
Gly Val Gly Gly Val Asp Tyr Val Leu Ser Cys Ile Leu Gly Asn Gln 
                 725                730                735
Ala Glu Ser Asn Asn Trp Gln Glu Leu Leu Gly Arg Leu Cys Leu Ile 
             740                745                750
Asp Arg Leu Leu Leu Glu Ile Ser Ala Glu Phe Tyr Pro His Ile Val 
         755                760                765
Ser Thr Asp Val Ser Gln Ala Glu Pro Val Glu Ile Arg Tyr Lys Lys 
     770                775                780
Leu Leu Ser Leu Leu Ala Phe Ala Leu Gln Ser Ile Asp Asn Ser His 
 785                790                795                800
Ser Met Val Gly Lys Leu Ser Arg Arg Ile Tyr Leu Ser Ser Ala Arg 
                 805                810                815
Met Val Thr Thr Val Pro Pro Leu Phe Ser Lys Leu Val Thr Met Leu 
             820                825                830
Ser Ala Ser Gly Ser Ser His Phe Ala Arg Met Arg Arg Arg Leu Met 
         835                840                845
Ala Ile Ala Asp Glu Val Glu Ile Ala Glu Val Ile Gln Leu Gly Ser 
     850                855                860
Glu Asp Thr Leu Asp Gly Gln Gln Asp Ser Ser Gln Ala Leu Ala Pro 
 865                870                875                880
Pro Arg Tyr Pro Glu Ser Ser Ser Leu Glu His Thr Ala His Val Glu 
                 885                890                895
Lys Thr Gly Lys Gly Leu Lys Ala Thr Arg Leu Ser Ala Ser Ser Glu 
             900                905                910
Asp Ile Ser Asp Arg Leu Ala Gly Val Ser Val Gly Leu Pro Ser Ser 
         915                920                925
Ala Thr Thr Glu Gln Pro Lys Pro Thr Val Gln Thr Lys Gly Arg Pro 
     930                935                940
His Ser Gln Cys Leu Asn Ser Ser Pro Leu Ser Pro Pro Gln Leu Met 
 945                950                955                960
Phe Pro Ala Ile Ser Ala Pro Cys Ser Ser Ala Pro Ser Val Pro Ala 
                 965                970                975
Gly Ser Val Thr Asp Ala Ser Lys His Arg Pro Arg Ala Phe Val Pro 
             980                985                990
Cys Lys Ile Pro Ser Ala Ser Pro Gln Thr Gln Arg Lys Phe Ser Leu 
         995                1000                1005
Gln Phe Gln Arg Thr Cys Ser Glu Asn Arg Asp Ser Glu Lys Leu Ser 
     1010                1015                1020
Pro Val Phe Thr Gln Ser Arg Pro Pro Pro Ser Ser Asn Ile His Arg 
 1025                1030                1035                1040
Ala Lys Ala Ser Arg Pro Val Pro Gly Ser Thr Ser Lys Leu Gly Asp 
                 1045                1050                1055
Ala Ser Lys Asn Ser Met Thr Leu Asp Leu Asn Ser Ala Ser Gln Cys 
             1060                1065                1070
Asp Asp Ser Phe Gly Ser Gly Ser Asn Ser Gly Ser Ala Val Ile Pro 
         1075                1080                1085
Ser Glu Glu Thr Ala Phe Thr Pro Ala Glu Asp Lys Cys Arg Leu Asp 
     1090                1095                1100
Val Asn Pro Glu Leu Asn Ser Ser Ile Glu Asp Leu Leu Glu Ala Ser 
 1105                1110                1115                1120
Met Pro Ser Ser Asp Thr Thr Val Thr Phe Lys Ser Glu Val Ala Val 
                 1125                1130                1135
Leu Ser Pro Glu Lys Ala Glu Ser Asp Asp Thr Tyr Lys Asp Asp Val 
             1140                1145                1150
Asn His Asn Gln Lys Cys Lys Glu Lys Met Glu Ala Glu Glu Glu Glu 
         1155                1160                1165
Ala Leu Ala Ile Ala Met Ala Met Ser Ala Ser Gln Asp Ala Leu Pro 
     1170                1175                1180
Ile Val Pro Gln Leu Gln Val Glu Asn Gly Glu Asp Ile Ile Ile Ile 
 1185                1190                1195                1200
Gln Gln Asp Thr Pro Glu Thr Leu Pro Gly His Thr Lys Ala Asn Glu 
                 1205                1210                1215
Pro Tyr Arg Glu Asp Thr Glu Trp Leu Lys Gly Gln Gln Ile Gly Leu 
             1220                1225                1230
Gly Ala Phe Ser Ser Cys Tyr Gln Ala Gln Asp Val Gly Thr Gly Thr 
         1235                1240                1245
Leu Met Ala Val Lys Gln Val Thr Tyr Val Arg Asn Thr Ser Ser Glu 
     1250                1255                1260
Gln Glu Glu Val Val Glu Ala Leu Arg Glu Glu Ile Arg Met Met Ser 
 1265                1270                1275                1280
His Leu Asn His Pro Asn Ile Ile Arg Met Leu Gly Ala Thr Cys Glu 
                 1285                1290                1295
Lys Ser Asn Tyr Asn Leu Phe Ile Glu Trp Met Ala Gly Ala Ser Val 
             1300                1305                1310
Ala His Leu Leu Ser Lys Tyr Gly Ala Phe Lys Glu Ser Val Val Ile 
         1315                1320                1325
Asn Tyr Thr Glu Gln Leu Leu Arg Gly Leu Ser Tyr Leu His Glu Asn 
     1330                1335                1340
Gln Ile Ile His Arg Asp Val Lys Gly Ala Asn Leu Leu Ile Asp Ser 
 1345                1350                1355                1360
Thr Gly Gln Arg Leu Arg Ile Ala Asp Phe Gly Ala Ala Ala Arg Leu 
                 1365                1370                1375
Ala Ser Lys Gly Thr Gly Ala Gly Glu Phe Gln Gly Gln Leu Leu Gly 
             1380                1385                1390
Thr Ile Ala Phe Met Ala Pro Glu Val Leu Arg Gly Gln Gln Tyr Gly 
         1395                1400                1405
Arg Ser Cys Asp Val Trp Ser Val Gly Cys Ala Ile Ile Glu Met Ala 
     1410                1415                1420
Cys Ala Lys Pro Pro Trp Asn Ala Glu Lys His Ser Asn His Leu Ala 
 1425                1430                1435                1440
Leu Ile Phe Lys Ile Ala Ser Ala Thr Thr Ala Pro Ser Ile Pro Ser 
                 1445                1450                1455
His Leu Ser Pro Gly Leu Arg Asp Val Ala Leu Arg Cys Leu Glu Leu 
             1460                1465                1470
Gln Pro Gln Asp Arg Pro Pro Ser Arg Glu Leu Leu Lys His Pro Val 
         1475                1480                1485
Phe Arg Thr Thr Trp 
     1490



<210> 8587
<211> 5234
<212> DNA
<213> Homo sapiens
<308> XM_042066
<400> 8587

cgagccctg  ggcaggcgg  ggcggagga  ccctcaagg  gagcagcgc  cccgcggct  60
ccgcgggac  gctgcggga  gcgggcagc  ggggccgcg  gcgggcgga  tggcggcgg  120
ggcagctgc  caaagtgcg  agtgtggag  tggaccagc  gcctgagca  ccgctcttc  180
ttgccgcct  accgccggc  tcctcgact  ccccgtcgc  ggagcccgc  gacgcagcg  240
ggagtggga  cggcttcca  cctgtggcg  tgccgccgc  ccacggagc  gcgagccgc  300
gcggcgccc  ccttaccga  tcggtggcg  cgccggaca  cggcgcctc  agtcccgca  360
cggccgagc  cggggagaa  cgggcgccc  ccgccgagc  gtctcctgc  gcggccccc  420
ccggtcgtg  gatggagaa  aaagaaact  tcaaagggt  gcacaagat  gatgatcgt  480
cagaggaac  aatgatcag  gagaaactg  aggcaacct  tatgccagc  tggaagcac  540
aatggttgg  aaggagaaa  aggcgaggg  ctgtggtgg  aaaaccaat  ccagttaaa  600
gagatggat  tgaaatgaa  cacttagca  ctgagtctc  aggagaggt  caggcaagt  660
cggcttcac  agcttccaa  ggccgacgc  gtccttctc  tggcaactc  ccatcaggt  720
gcacagtga  atcagaatc  ccaggagta  ggagaaaaa  agtttcccc  gtgcctttt  780
agagtggca  aatcacacc  ccccgaaga  ccccttcac  agatggctt  tcaccatat  840
gccctgagg  aacaaaccg  cgtgttaac  aagtgatgc  ggccagact  tacttactg  900
agcagatag  gcctaactc  ttcctgatt  gaggagaca  cccagacaa  aaataccgg  960
tgtttattg  gcctcagaa  tgcagctgt  cacgtggaa  attctgtat  catctgcta  1020
ttgtgatgc  ccgggtgtt  caactagaa  cttcagacc  aatgttatg  agaaaaact  1080
taaagaatt  tgaggttga  agtttgttc  agaaatatc  cagtaggcg  agctcaagg  1140
tcaaagctc  atctcgtaa  accatccag  agtttgttt  acgcatgtc  aattctcat  1200
cattgtcat  atctagtac  tctacgtct  gttcagaaa  cagcataaa  gatgaagag  1260
aacagatgt  tcctatttg  ttgttgggc  tgcttgatg  agaaagtct  acagtgtgt  1320
aagacggct  caggaacaa  ctgcaccac  actgcatgt  aatttgggc  gaagagtgt  1380
gaagaaata  agaaccttt  atatgtccc  tttgtagat  taagtggag  tctcatgat  1440
tctacagcc  cgagttgtc  agtcctgtg  attcccctt  ttccctcag  gctgcacag  1500
agcaaaccg  acagcagca  cctttggct  gatcacgaa  gaatcaaga  agcaatttt  1560
accttactc  ttatggaac  cagcaaatc  ctcctgctt  caaagattt  gctgagcca  1620
ggattcagg  gtttggaat  gaactcgtt  gctgcttat  ttctagaaa  tggaatgtg  1680
gagagatgg  cctcaggcg  ctttcccat  atgtcagtg  ggccctgct  ttggcaaat  1740
gggagagca  tggaaattc  gggggcagc  gtggaagca  cccgagtgg  ggagccacc  1800
gtgggtctt  ccagaccag  atctcagga  atgtggtgg  ggcatgctg  agcgttctg  1860
caatggtct  tgctgaccc  gtctacaaa  tgtacgttg  tgctttaaa  acattgaga  1920
ccatgctgg  atatactcc  tgccacagt  tagcggaaa  aatcaaact  cagagactt  1980
tccagccag  tgtagacac  atcctagtc  aatgtgcag  tgccaatag  cgcacaagt  2040
agctgtcca  atcaacact  ttggaactg  gcaaaggcc  agcaggaga  ttggcagtt  2100
gcagagaaa  actaaaagc  ggatccatt  gtattggtg  tgttgatta  gtcttaaat  2160
gtattcttg  aaaccaaac  gaatcaaac  attggcaag  acttcttgg  cgcctttgt  2220
ttatagata  actgttgtt  gaatttcct  ctgaatttt  tcctcatat  gtcagtact  2280
atgtttcac  agctgagcc  gttgaaatc  ggtataaga  gctgctgtc  ctcttaacc  2340
ttgctttgc  gtccattga  aattcccac  caatggttg  caaactttc  agaaggatc  2400
acttgagtt  tgcaagaat  gttactaca  taccccatg  gttttcaaa  ctgttagaa  2460
tgctgagtg  ttccagttc  actcacttc  ccaggatgc  tcgccgttt  atggctatt  2520
cagatgagg  ggaaattgc  gaagccatc  agttgggcg  agaagacac  ttggatggt  2580
aacaggaca  cttcttgca  gcatctgtt  ccaacaact  tctggaaac  acagagaac  2640
gttcccctg  gtgcacagt  catttagag  aaactggaa  aggattatg  gctacaaaa  2700
tgagtgcca  ttcagagga  atttctgag  gactggcca  catttcagt  ggaccttct  2760
gttcaacaa  aacaacaac  acaacaaca  agcaaccaa  gccaatggt  caaacaaaa  2820
gcagacccc  cagtcagtg  ttgaactcc  ctcctttat  tcatcattc  caattaatg  2880
ttccagcct  gtcaacccc  tcttcttct  ccccatctg  accagctgg  actgcaaca  2940
atgtctcta  gcatagact  cagggattc  ttccctgca  aataccttc  gcatctcct  3000
aaacacagc  caagttttc  ctacaattc  acagaaact  tcctgaaaa  aaagactca  3060
ataaacttt  cccagtctt  actcagtca  gacccttgc  ctccagtaa  atacacagg  3120
caaagccat  tagacctac  ccaggtaat  caagtaaac  gggagatcc  tcaaaaaat  3180
gcatgacac  tgatctgaa  agtagttcc  aatgtgatg  cagctttgg  tgtagcagc  3240
atagtagta  tgctgttat  cccagtgac  agacagtgt  caccccagt  gaggagaaa  3300
gcagattag  tgtcaatac  gagctcaac  ccagtattg  ggaccttct  gaagcatct  3360
tgccttcaa  tgatacaac  gtaactttt  agtcagaag  tgctgtcct  tctcctgaa  3420
aggctgaaa  tgatgatac  tacaaagat  atgtgaatc  taatcaaaa  tgcaaagag  3480
agatggaag  tgaagaaga  gaagcttta  caattgcca  ggcaatgtc  gcgtctcag  3540
atgccctcc  catagttcc  cagctgcag  ttgaaaatg  agaagatat  atcattatt  3600
aacaggata  accagagac  ctaccagga  ataccaaag  aaaacaacc  tatagagaa  3660
acactgaat  gctgaaagg  caacagata  gccttggag  attttcttc  tgttatcag  3720
ctcaagatg  gggaactgg  actttaatg  ctgttaaac  ggtgactta  gtcagaaac  3780
catcttctg  gcaagaaga  gtagtagaa  cactaagag  agagataag  atgatgagc  3840
atctgaatc  tccaaacat  attaggatg  tgggagcca  gtgtgagaa  agcaattac  3900
atctcttca  tgaatggat  gcaggggga  cggtggctc  tttgctgag  aaatatgga  3960
ccttcaaag  atcagtagt  attaactac  ctgaacagt  actccgtgg  ctttcgtat  4020
tccatgaaa  ccaaatcat  cacagagat  tcaaaggtg  caatttgct  attgacagc  4080
ctggtcaga  actaagaat  gcagatttt  gagctgcag  caggttggc  tcaaaagga  4140
ctggtgcag  agagtttca  ggacaatta  tggggacaa  tgcatttat  gcacctgag  4200
tactaagag  tcaacagta  ggaaggagc  gtgatgtat  gagtgttgg  tgtgctatt  4260
tagaaatgg  ttgtgcaaa  ccaccatgg  atgcagaaa  acactccaa  catcttgct  4320
tgatattta  ggtaattat  gctagtgca  ctactgctc  atcgatccc  tcacatttg  4380
ctcctggtt  acgagatgt  gctcttcgt  gtttagaac  tcaacctca  gacagacct  4440
catcaagag  gctactgaa  catccagtc  ttcgtacta  atggtagcc  attatgcag  4500
tcaactaca  tagaaacag  atgctcaac  agagaaaaa  aacttgtgg  gaaccacat  4560
gatattcta  tggccatga  gccactgaa  agctatgaa  gaggccagt  gggaaccct  4620
acctaagta  gtgattgac  aatcatgat  tgtacctaa  ctcagtatg  aaaagccca  4680
actagtgca  aaactgtaa  ctgtgcctt  caaagaact  gccctaggt  aacaggaaa  4740
caatgaagt  tgcatgact  aattgcaga  gcataattt  atttttttg  agcactttt  4800
cagcaatat  agcggctga  gggctcagg  tctatttta  tatttcaat  attcttcca  4860
ttcatatag  gatcacaag  agggggttc  gcaattccg  tcaaatttt  tgtcactgg  4920
tataaaatc  gtatctgcc  cttttaggt  agagtatgc  atgagtagc  atacataca  4980
atattttta  aagttgata  ttctttatg  cccacagtt  acctttatt  tcttaaata  5040
cagggcagt  gtggctcat  gtgcatttt  ctgttggcc  attcatttc  tttttggaa  5100
ttatggttt  gtattttca  gtttattta  attcatttt  gtttattca  ggaaagctg  5160
tcttttttt  aaaccagaa  aaaaaaatg  actagatat  aagtagagt  cattaaata  5220
cttgctatt  tcag  5234



<210> 8588
<211> 1351
<212> PRT
<213> Homo sapiens
<308> XP_042066
<400> 8588

Met Glu Asn Lys Glu Thr Leu Lys Gly Leu His Lys Met Asp Asp Arg 
  1               5                  10                  15
Pro Glu Glu Arg Met Ile Arg Glu Lys Leu Lys Ala Thr Cys Met Pro 
             20                  25                  30
Ala Trp Lys His Glu Trp Leu Glu Arg Arg Asn Arg Arg Gly Pro Val 
         35                  40                  45
Val Val Lys Pro Ile Pro Val Lys Gly Asp Gly Ser Glu Met Asn His 
     50                  55                  60
Leu Ala Ala Glu Ser Pro Gly Glu Val Gln Ala Ser Ala Ala Ser Pro 
 65                  70                  75                  80
Ala Ser Lys Gly Arg Arg Ser Pro Ser Pro Gly Asn Ser Pro Ser Gly 
                 85                  90                  95
Arg Thr Val Lys Ser Glu Ser Pro Gly Val Arg Arg Lys Arg Val Ser 
             100                105                110
Pro Val Pro Phe Gln Ser Gly Arg Ile Thr Pro Pro Arg Arg Ala Pro 
         115                120                125
Ser Pro Asp Gly Phe Ser Pro Tyr Ser Pro Glu Glu Thr Asn Arg Arg 
     130                135                140
Val Asn Lys Val Met Arg Ala Arg Leu Tyr Leu Leu Gln Gln Ile Gly 
 145                150                155                160
Pro Asn Ser Phe Leu Ile Gly Gly Asp Ser Pro Asp Asn Lys Tyr Arg 
                 165                170                175
Val Phe Ile Gly Pro Gln Asn Cys Ser Cys Ala Arg Gly Thr Phe Cys 
             180                185                190
Ile His Leu Leu Phe Val Met Leu Arg Val Phe Gln Leu Glu Pro Ser 
         195                200                205
Asp Pro Met Leu Trp Arg Lys Thr Leu Lys Asn Phe Glu Val Glu Ser 
     210                215                220
Leu Phe Gln Lys Tyr His Ser Arg Arg Ser Ser Arg Ile Lys Ala Pro 
 225                230                235                240
Ser Arg Asn Thr Ile Gln Lys Phe Val Ser Arg Met Ser Asn Ser His 
                 245                250                255
Thr Leu Ser Ser Ser Ser Thr Ser Thr Ser Ser Ser Glu Asn Ser Ile 
             260                265                270
Lys Asp Glu Glu Glu Gln Met Cys Pro Ile Cys Leu Leu Gly Met Leu 
         275                280                285
Asp Glu Glu Ser Leu Thr Val Cys Glu Asp Gly Cys Arg Asn Lys Leu 
     290                295                300
His His His Cys Met Ser Ile Trp Ala Glu Glu Cys Arg Arg Asn Arg 
 305                310                315                320
Glu Pro Leu Ile Cys Pro Leu Cys Arg Ser Lys Trp Arg Ser His Asp 
                 325                330                335
Phe Tyr Ser His Glu Leu Ser Ser Pro Val Asp Ser Pro Ser Ser Leu 
             340                345                350
Arg Ala Ala Gln Gln Gln Thr Val Gln Gln Gln Pro Leu Ala Gly Ser 
         355                360                365
Arg Arg Asn Gln Glu Ser Asn Phe Asn Leu Thr His Tyr Gly Thr Gln 
     370                375                380
Gln Ile Pro Pro Ala Tyr Lys Asp Leu Ala Glu Pro Trp Ile Gln Val 
 385                390                395                400
Phe Gly Met Glu Leu Val Gly Cys Leu Phe Ser Arg Asn Trp Asn Val 
                 405                410                415
Arg Glu Met Ala Leu Arg Arg Leu Ser His Asp Val Ser Gly Ala Leu 
             420                425                430
Leu Leu Ala Asn Gly Glu Ser Thr Gly Asn Ser Gly Gly Ser Ser Gly 
         435                440                445
Ser Ser Pro Ser Gly Gly Ala Thr Ser Gly Ser Ser Gln Thr Ser Ile 
     450                455                460
Ser Gly Asp Val Val Glu Ala Cys Cys Ser Val Leu Ser Met Val Cys 
 465                470                475                480
Ala Asp Pro Val Tyr Lys Val Tyr Val Ala Ala Leu Lys Thr Leu Arg 
                 485                490                495
Ala Met Leu Val Tyr Thr Pro Cys His Ser Leu Ala Glu Arg Ile Lys 
             500                505                510
Leu Gln Arg Leu Leu Gln Pro Val Val Asp Thr Ile Leu Val Lys Cys 
         515                520                525
Ala Asp Ala Asn Ser Arg Thr Ser Gln Leu Ser Ile Ser Thr Leu Leu 
     530                535                540
Glu Leu Cys Lys Gly Gln Ala Gly Glu Leu Ala Val Gly Arg Glu Ile 
 545                550                555                560
Leu Lys Ala Gly Ser Ile Gly Ile Gly Gly Val Asp Tyr Val Leu Asn 
                 565                570                575
Cys Ile Leu Gly Asn Gln Thr Glu Ser Asn Asn Trp Gln Glu Leu Leu 
             580                585                590
Gly Arg Leu Cys Leu Ile Asp Arg Leu Leu Leu Glu Phe Pro Ala Glu 
         595                600                605
Phe Tyr Pro His Ile Val Ser Thr Asp Val Ser Gln Ala Glu Pro Val 
     610                615                620
Glu Ile Arg Tyr Lys Lys Leu Leu Ser Leu Leu Thr Phe Ala Leu Gln 
 625                630                635                640
Ser Ile Asp Asn Ser His Ser Met Val Gly Lys Leu Ser Arg Arg Ile 
                 645                650                655
Tyr Leu Ser Ser Ala Arg Met Val Thr Thr Val Pro His Val Phe Ser 
             660                665                670
Lys Leu Leu Glu Met Leu Ser Val Ser Ser Ser Thr His Phe Thr Arg 
         675                680                685
Met Arg Arg Arg Leu Met Ala Ile Ala Asp Glu Val Glu Ile Ala Glu 
     690                695                700
Ala Ile Gln Leu Gly Val Glu Asp Thr Leu Asp Gly Gln Gln Asp Ser 
 705                710                715                720
Phe Leu Gln Ala Ser Val Pro Asn Asn Tyr Leu Glu Thr Thr Glu Asn 
                 725                730                735
Ser Ser Pro Glu Cys Thr Val His Leu Glu Lys Thr Gly Lys Gly Leu 
             740                745                750
Cys Ala Thr Lys Leu Ser Ala Ser Ser Glu Asp Ile Ser Glu Arg Leu 
         755                760                765
Ala Ser Ile Ser Val Gly Pro Ser Ser Ser Thr Thr Thr Thr Thr Thr 
     770                775                780
Thr Thr Glu Gln Pro Lys Pro Met Val Gln Thr Lys Gly Arg Pro His 
 785                790                795                800
Ser Gln Cys Leu Asn Ser Ser Pro Leu Ser His His Ser Gln Leu Met 
                 805                810                815
Phe Pro Ala Leu Ser Thr Pro Ser Ser Ser Thr Pro Ser Val Pro Ala 
             820                825                830
Gly Thr Ala Thr Asp Val Ser Lys His Arg Leu Gln Gly Phe Ile Pro 
         835                840                845
Cys Arg Ile Pro Ser Ala Ser Pro Gln Thr Gln Arg Lys Phe Ser Leu 
     850                855                860
Gln Phe His Arg Asn Cys Pro Glu Asn Lys Asp Ser Asp Lys Leu Ser 
 865                870                875                880
Pro Val Phe Thr Gln Ser Arg Pro Leu Pro Ser Ser Asn Ile His Arg 
                 885                890                895
Pro Lys Pro Ser Arg Pro Thr Pro Gly Asn Thr Ser Lys Gln Gly Asp 
             900                905                910
Pro Ser Lys Asn Ser Met Thr Leu Asp Leu Asn Ser Ser Ser Lys Cys 
         915                920                925
Asp Asp Ser Phe Gly Cys Ser Ser Asn Ser Ser Asn Ala Val Ile Pro 
     930                935                940
Ser Asp Glu Thr Val Phe Thr Pro Val Glu Glu Lys Cys Arg Leu Asp 
 945                950                955                960
Val Asn Thr Glu Leu Asn Ser Ser Ile Glu Asp Leu Leu Glu Ala Ser 
                 965                970                975
Met Pro Ser Ser Asp Thr Thr Val Thr Phe Lys Ser Glu Val Ala Val 
             980                985                990
Leu Ser Pro Glu Lys Ala Glu Asn Asp Asp Thr Tyr Lys Asp Asp Val 
         995                1000                1005
Asn His Asn Gln Lys Cys Lys Glu Lys Met Glu Ala Glu Glu Glu Glu 
     1010                1015                1020
Ala Leu Ala Ile Ala Met Ala Met Ser Ala Ser Gln Asp Ala Leu Pro 
 1025                1030                1035                1040
Ile Val Pro Gln Leu Gln Val Glu Asn Gly Glu Asp Ile Ile Ile Ile 
                 1045                1050                1055
Gln Gln Asp Thr Pro Glu Thr Leu Pro Gly His Thr Lys Ala Lys Gln 
             1060                1065                1070
Pro Tyr Arg Glu Asp Thr Glu Trp Leu Lys Gly Gln Gln Ile Gly Leu 
         1075                1080                1085
Gly Ala Phe Ser Ser Cys Tyr Gln Ala Gln Asp Val Gly Thr Gly Thr 
     1090                1095                1100
Leu Met Ala Val Lys Gln Val Thr Tyr Val Arg Asn Thr Ser Ser Glu 
 1105                1110                1115                1120
Gln Glu Glu Val Val Glu Ala Leu Arg Glu Glu Ile Arg Met Met Ser 
                 1125                1130                1135
His Leu Asn His Pro Asn Ile Ile Arg Met Leu Gly Ala Thr Cys Glu 
             1140                1145                1150
Lys Ser Asn Tyr Asn Leu Phe Ile Glu Trp Met Ala Gly Gly Ser Val 
         1155                1160                1165
Ala His Leu Leu Ser Lys Tyr Gly Ala Phe Lys Glu Ser Val Val Ile 
     1170                1175                1180
Asn Tyr Thr Glu Gln Leu Leu Arg Gly Leu Ser Tyr Leu His Glu Asn 
 1185                1190                1195                1200
Gln Ile Ile His Arg Asp Val Lys Gly Ala Asn Leu Leu Ile Asp Ser 
                 1205                1210                1215
Thr Gly Gln Arg Leu Arg Ile Ala Asp Phe Gly Ala Ala Ala Arg Leu 
             1220                1225                1230
Ala Ser Lys Gly Thr Gly Ala Gly Glu Phe Gln Gly Gln Leu Leu Gly 
         1235                1240                1245
Thr Ile Ala Phe Met Ala Pro Glu Val Leu Arg Gly Gln Gln Tyr Gly 
     1250                1255                1260
Arg Ser Cys Asp Val Trp Ser Val Gly Cys Ala Ile Ile Glu Met Ala 
 1265                1270                1275                1280
Cys Ala Lys Pro Pro Trp Asn Ala Glu Lys His Ser Asn His Leu Ala 
                 1285                1290                1295
Leu Ile Phe Lys Val Ile Ile Ala Ser Ala Thr Thr Ala Pro Ser Ile 
             1300                1305                1310
Pro Ser His Leu Ser Pro Gly Leu Arg Asp Val Ala Leu Arg Cys Leu 
         1315                1320                1325
Glu Leu Gln Pro Gln Asp Arg Pro Pro Ser Arg Glu Leu Leu Lys His 
     1330                1335                1340
Pro Val Phe Arg Thr Thr Trp 
 1345                1350



<210> 8589
<211> 5180
<212> DNA
<213> Rattus norvegicus
<308> U48596
<400> 8589

gaattccgc  cccggggcg  gacaagagg  ctgctttcc  aagagaagg  ttcgcgtct  60
tctgcagca  gcgacagtc  cgggcgcca  ctgcgcttc  ggcgcgggc  aggctggtg  120
gcgccgggc  cccagcgcc  gctactgag  gcgtgaagt  accgaccgt  agtcctccg  180
cttgcgtcc  cttccagca  cagggactc  cgccccaat  actgcttgc  caagggtgg  240
cgagctccg  ccgagccgc  gccccgccc  gtactacct  gcagctgcc  gggtgcagc  300
cacagcgcc  cgcgcggcc  cagcagagc  cctgccctc  cacctgcgc  gcgcgcccg  360
cgctccgtg  tcccgagac  ggagacgcg  ccccgctcc  gctcgcgcc  gcgcactcg  420
cgcagcgcg  gcgcccgcc  ctccgcccg  cccccgcgc  ctccccgcc  cctccctcc  480
ccgcaggca  gagcgaatg  agcccgcga  agaaaatgg  ggcggcggc  ggcgatcgc  540
cctcgtcgt  gggattccc  ggcgccgcg  cggcgagcc  cgaggcggg  ggcggcggc  600
gagctctcc  gggaagcgg  gcgcccgca  cgggcgcgg  gctgctgcg  gagactggc  660
gcgcgggcc  cgagcgcgc  gactggcgg  ggcagcagc  gcgcaaagt  aggagtgtg  720
agctggacc  gctgccgga  cagccgctc  tcctcaccg  ctcgccgcc  tgcccatct  780
cttccccgt  gccggagcc  gcggacgcg  ctgcaggag  gagtggctt  cagcctgcg  840
cgggaccgc  acccccggg  gcagcgagt  gctgcggct  ccactctgc  gagctggcg  900
ccgcgcggg  cagcggcgc  cggagcccc  cgggggccg  gccgccctc  gcagcggcc  960
cctccggtc  agagatgga  aataaagaa  ccctcaaag  attgcacaa  atggatgac  1020
gcccagagg  gcgaatgat  agggagaag  tcaaggcga  ctgtatgcc  gcctggaag  1080
acgagtggt  agaaaggag  aacaggaga  gccctgtgg  ggtgaaacc  atccctatt  1140
aaggagatg  atctgaaat  agtaacttg  cagctgagc  ccaaggaga  ggccaggca  1200
gctctgctg  accagctcc  aagggccga  gaagcccgt  tcctggaag  tccccatca  1260
ggcgctcag  gaagccgga  tccccagga  tgagacgga  acgagtgtc  ccagtgcct  1320
tccagagtg  cagaatcac  ccacctcga  gagccccgt  gccagatgg  ttctcaccg  1380
acagcccag  ggagacgag  cgccgtgtg  acaaagtga  gagggccag  ctgtacctc  1440
tgcagcaga  aggacccaa  tctttcctg  ttggaggag  cagtccaga  aataaatac  1500
gcgtgttta  tgggccaca  aactgcagc  gtgggcgtg  gacattctg  attcacctc  1560
tgtttgtca  gctccgggt  ttccagcta  aaccctccg  ccccatgct  tggagaaaa  1620
ctttaaaaa  ttttgaggt  gagagtttg  tccagaaat  ccacagtag  cgtagctca  1680
gaatcaaag  tccatctcg  aacaccatc  agaagtttg  ctcacgcat  tcaaactgt  1740
acacattgt  atcgtctag  acatccaca  ctagttcag  aaacagcat  aaggatgaa  1800
aggagcaga  gtgtcccat  tgcttgttg  gcatgctgg  tgaggagag  ctgactgtg  1860
gtgaagacg  ctgcaggaa  aagctgcac  accactgca  gtcaatctg  gcagaagaa  1920
gtagaagaa  tagagaacc  ttaatatgt  ccctttgta  atctaagtg  agatcccat  1980
acttctaca  ccatgagtt  tcaagccct  tggattccc  tacctccct  cgaggtgta  2040
agcagccct  ctccccgca  cagcctgtg  ccggatcac  gcggaggaa  caggaaagc  2100
attttaacc  tactcatta  ggaacccag  agattcctc  cgcttacaa  gatttagcc  2160
agccatgga  tcaggcatt  ggaatggag  tcgttggct  cttattctc  agaaactgg  2220
acgtaaggg  gatggccct  aggcgcctt  cccacgatg  tagcggggc  ctgttgttg  2280
cgaacgggg  gagcactgg  acttctgga  gcggcagcg  aggcagcct  agtgctggc  2340
ccgccagtg  gtcttccca  cccagcatc  caggggacg  ggtggaggc  ttctgcagc  2400
tcctgtcta  cgtgtgcgc  gaccctgtc  acaaagtgt  cgttgctgc  ttaaaaaca  2460
tgagagcca  gctggtata  actccttgc  acagcctgg  agaaagaat  aaacttcag  2520
gacttctcc  gccagtggt  gacaccatc  tagtgaagt  cgcagacgc  aatagccgc  2580
cgagtcagc  gtccatatc  acactgttg  agctctgca  gggccaagc  ggggagttg  2640
cagttggac  agaaatact  aaagctgga  ccatcggtg  tggtggcgt  gattacgtc  2700
taagttgta  tcttggaaa  caagctgaa  caaacaact  gcaagaact  ctgggtcgc  2760
tctgtctta  agacagatt  ctcttggaa  tttctgcgg  attttatcc  catattgtc  2820
gtaccgatg  ctcacaagc  gagcctgtt  aaatcaggt  taagaagct  ctgtccctc  2880
tagcctttg  cttgcaatc  attgacaat  cccactcta  ggtcggcaa  ctctcgcgg  2940
ggatttatc  gagctcagc  cgaatggtg  ccacagtgc  ccccctgtt  tccaagctg  3000
taaccatgc  aagtgcttc  ggatcctcc  acttcgcca  gatgcgccg  cgtctgatg  3060
ccattgcag  cgaggtaga  attgccgag  tcatccagc  gggttcgga  gacactttg  3120
atggccagc  ggacagctc  caggcattg  cccctcccc  ctatccaga  agcagctcc  3180
ttgagcaca  agcccatgt  gagaaaact  gaaaaggat  aaaagctac  agactgagt  3240
ccagctcag  ggacatttc  gacagactg  ctggcgttt  tgtaggact  cctagttca  3300
caacaacag  acaaccaaa  ccaacagtt  aaacaaaag  cagacccca  agtcagtgt  3360
tgaactcct  tcctttgtc  cctcctcag  taatgtttc  agcaatatc  gccccatgt  3420
catctgccc  gtctgtccc  gctggctct  taacagatg  ttctaagca  agacctcgg  3480
cgtttgttc  ctgtaaaat  ccctctgcg  ctccccaaa  acagcgcaa  ttttcccta  3540
agttccaga  gacctgctc  gagaaccga  actcagaaa  actctcccc  gtctttact  3600
agtcgagac  cccaccctc  agtaacata  acagggcaa  ggcatcccg  cccgttccg  3660
gtagcacaa  caaactagg  gatgcctca  aaaacagca  gacactcga  ctgaacagt  3720
cttcccagt  tgatgacag  tttggcagt  gcagcaaca  tggcagcgc  gtcataccc  3780
gtgaggaga  ggcattcac  ccagcagag  acaagtgca  gttagatgt  aaccccgag  3840
tcaactcca  tatcgagga  cttcttgaa  catctatgc  ttcaagtga  acaacagtc  3900
ctttcaagt  cgaagtcgc  gtcctctct  ctgagaagg  cgaaagtga  gacacctac  3960
aagatgacg  caatcacaa  caaaagtgc  aagagaaga  ggaggctga  gaagaggag  4020
cgctcgcga  tgccatggc  atgtcggct  ctcaggacg  cctccccat  gtccctcag  4080
tgcaggtgg  aaatggaga  gatatcatc  tcatccagc  ggatacacc  gaaacccta  4140
cagggcata  caaagcgaa  gagccctac  gagaagaca  cgagtggct  aaagggcag  4200
agataggcc  cggagcatt  tcttcttgt  accaagcac  ggatgtggg  actggaact  4260
taatggctg  gaaacaggt  acctacgtc  gaaacacat  ttctgagca  gaggaagtg  4320
tggaagcct  gagggaaga  atcaggatg  tgagccacc  caaccatcc  aacatcatc  4380
ggatgctgg  ggccacgtg  gagaagagc  actacaacc  cttcatcga  tggatggcg  4440
gagcctccg  ggctcacct  ttgagtaaa  atggagctt  caaggagtc  gtggtcatt  4500
actacacag  gcagttact  cgtggcctt  cctatctcc  cgagaacca  atcattcac  4560
gagacgtca  aggggccaa  ctgctcatt  acagcaccg  tcagcggct  agaattgca  4620
acttcggtg  tgccgccag  ttggcatcc  aaggaactg  tgcaggaga  ttccaggga  4680
agttactgg  gacaattgc  ttcatggcg  ctgaggtac  aagaggtca  cagtacggt  4740
ggagctgtg  cgtctggag  gttggctgc  ccattatag  aatggcctg  gcaaaacca  4800
cctggaacg  agaaaagca  tccaatcat  ttgctttga  atttaagat  gcgagtgca  4860
ctactgcac  atccatccc  tcacacctg  ccccgggcc  gcgagacgt  gctctgcgc  4920
gtttagaac  tcaacctca  gacagacct  cgtcaagag  gctactgaa  catcctgtc  4980
tccgtacaa  atggtagtc  actgctcag  gtgcgcaac  aggaaagaa  actcgcggg  5040
agccacgtt  atagtctgc  ggcctcata  cactgacca  aagaggggc  agtggggag  5100
ccgcaccta  gcatgtgac  gacaaatca  gactgcacc  gagctccgt  tgcagacgg  5160
tacaactcg  gcaggagctg  5180



<210> 8590
<211> 1493
<212> PRT
<213> Rattus norvegicus
<308> Q62925
<400> 8590

Met Ala Ala Ala Ala Gly Asp Arg Ala Ser Ser Ser Gly Phe Pro Gly 
  1               5                  10                  15
Ala Ala Ala Ala Ser Pro Glu Ala Gly Gly Gly Gly Gly Ala Leu Gln 
             20                  25                  30
Gly Ser Gly Ala Pro Ala Ala Gly Ala Gly Leu Leu Arg Glu Thr Gly 
         35                  40                  45
Ser Ala Gly Arg Glu Arg Ala Asp Trp Arg Arg Gln Gln Leu Arg Lys 
     50                  55                  60
Val Arg Ser Val Glu Leu Asp Gln Leu Pro Glu Gln Pro Leu Phe Leu 
 65                  70                  75                  80
Thr Ala Ser Pro Pro Cys Pro Ser Thr Ser Pro Ser Pro Glu Pro Ala 
                 85                  90                  95
Asp Ala Ala Ala Gly Ala Ser Gly Phe Gln Pro Ala Ala Gly Pro Pro 
             100                105                110
Pro Pro Gly Ala Ala Ser Arg Cys Gly Ser His Ser Ala Glu Leu Ala 
         115                120                125
Ala Ala Arg Asp Ser Gly Ala Arg Ser Pro Ala Gly Ala Glu Pro Pro 
     130                135                140
Ser Ala Ala Ala Pro Ser Gly Arg Glu Met Glu Asn Lys Glu Thr Leu 
 145                150                155                160
Lys Gly Leu His Lys Met Asp Asp Arg Pro Glu Glu Arg Met Ile Arg 
                 165                170                175
Glu Lys Leu Lys Ala Thr Cys Met Pro Ala Trp Lys His Glu Trp Leu 
             180                185                190
Glu Arg Arg Asn Arg Arg Gly Pro Val Val Val Lys Pro Ile Pro Ile 
         195                200                205
Lys Gly Asp Gly Ser Glu Met Ser Asn Leu Ala Ala Glu Leu Gln Gly 
     210                215                220
Glu Gly Gln Ala Gly Ser Ala Ala Pro Ala Pro Lys Gly Arg Arg Ser 
 225                230                235                240
Pro Ser Pro Gly Ser Ser Pro Ser Gly Arg Ser Gly Lys Pro Glu Ser 
                 245                250                255
Pro Gly Val Arg Arg Lys Arg Val Ser Pro Val Pro Phe Gln Ser Gly 
             260                265                270
Arg Ile Thr Pro Pro Arg Arg Ala Pro Ser Pro Asp Gly Phe Ser Pro 
         275                280                285
Tyr Ser Pro Glu Glu Thr Ser Arg Arg Val Asn Lys Val Met Arg Ala 
     290                295                300
Arg Leu Tyr Leu Leu Gln Gln Ile Gly Pro Asn Ser Phe Leu Ile Gly 
 305                310                315                320
Gly Asp Ser Pro Asp Asn Lys Tyr Arg Val Phe Ile Gly Pro Gln Asn 
                 325                330                335
Cys Ser Cys Gly Arg Gly Thr Phe Cys Ile His Leu Leu Phe Val Met 
             340                345                350
Leu Arg Val Phe Gln Leu Glu Pro Ser Asp Pro Met Leu Trp Arg Lys 
         355                360                365
Thr Leu Lys Asn Phe Glu Val Glu Ser Leu Phe Gln Lys Tyr His Ser 
     370                375                380
Arg Arg Ser Ser Arg Ile Lys Ala Pro Ser Arg Asn Thr Ile Gln Lys 
 385                390                395                400
Phe Val Ser Arg Met Ser Asn Cys His Thr Leu Ser Ser Ser Ser Thr 
                 405                410                415
Ser Thr Ser Ser Ser Glu Asn Ser Ile Lys Asp Glu Glu Glu Gln Met 
             420                425                430
Cys Pro Ile Cys Leu Leu Gly Met Leu Asp Glu Glu Ser Leu Thr Val 
         435                440                445
Cys Glu Asp Gly Cys Arg Asn Lys Leu His His His Cys Met Ser Ile 
     450                455                460
Trp Ala Glu Glu Cys Arg Arg Asn Arg Glu Pro Leu Ile Cys Pro Leu 
 465                470                475                480
Cys Arg Ser Lys Trp Arg Ser His Asp Phe Tyr Ser His Glu Leu Ser 
                 485                490                495
Ser Pro Val Asp Ser Pro Thr Ser Leu Arg Gly Val Gln Gln Pro Ser 
             500                505                510
Ser Pro Gln Gln Pro Val Ala Gly Ser Gln Arg Arg Asn Gln Glu Ser 
         515                520                525
Asn Phe Asn Leu Thr His Tyr Gly Thr Gln Gln Ile Pro Pro Ala Tyr 
     530                535                540
Lys Asp Leu Ala Glu Pro Trp Ile Gln Ala Phe Gly Met Glu Leu Val 
 545                550                555                560
Gly Cys Leu Phe Ser Arg Asn Trp Asn Val Arg Glu Met Ala Leu Arg 
                 565                570                575
Arg Leu Ser His Asp Val Ser Gly Ala Leu Leu Leu Ala Asn Gly Glu 
             580                585                590
Ser Thr Gly Thr Ser Gly Gly Gly Ser Gly Gly Ser Leu Ser Ala Gly 
         595                600                605
Ala Ala Ser Gly Ser Ser Gln Pro Ser Ile Ser Gly Asp Val Val Glu 
     610                615                620
Ala Phe Cys Ser Val Leu Ser Ile Val Cys Ala Asp Pro Val Tyr Lys 
 625                630                635                640
Val Tyr Val Ala Ala Leu Lys Thr Leu Arg Ala Met Leu Val Tyr Thr 
                 645                650                655
Pro Cys His Ser Leu Ala Glu Arg Ile Lys Leu Gln Arg Leu Leu Arg 
             660                665                670
Pro Val Val Asp Thr Ile Leu Val Lys Cys Ala Asp Ala Asn Ser Arg 
         675                680                685
Thr Ser Gln Leu Ser Ile Ser Thr Leu Leu Glu Leu Cys Lys Gly Gln 
     690                695                700
Ala Gly Glu Leu Ala Val Gly Arg Glu Ile Leu Lys Ala Gly Ser Ile 
 705                710                715                720
Gly Val Gly Gly Val Asp Tyr Val Leu Ser Cys Ile Leu Gly Asn Gln 
                 725                730                735
Ala Glu Ser Asn Asn Trp Gln Glu Leu Leu Gly Arg Leu Cys Leu Ile 
             740                745                750
Asp Arg Leu Leu Leu Glu Ile Ser Ala Glu Phe Tyr Pro His Ile Val 
         755                760                765
Ser Thr Asp Val Ser Gln Ala Glu Pro Val Glu Ile Arg Tyr Lys Lys 
     770                775                780
Leu Leu Ser Leu Leu Ala Phe Ala Leu Gln Ser Ile Asp Asn Ser His 
 785                790                795                800
Ser Met Val Gly Lys Leu Ser Arg Arg Ile Tyr Leu Ser Ser Ala Arg 
                 805                810                815
Met Val Thr Thr Val Pro Pro Leu Phe Ser Lys Leu Val Thr Met Leu 
             820                825                830
Ser Ala Ser Gly Ser Ser His Phe Ala Arg Met Arg Arg Arg Leu Met 
         835                840                845
Ala Ile Ala Asp Glu Val Glu Ile Ala Glu Val Ile Gln Leu Gly Ser 
     850                855                860
Glu Asp Thr Leu Asp Gly Gln Gln Asp Ser Ser Gln Ala Leu Ala Pro 
 865                870                875                880
Pro Arg Tyr Pro Glu Ser Ser Ser Leu Glu His Thr Ala His Val Glu 
                 885                890                895
Lys Thr Gly Lys Gly Leu Lys Ala Thr Arg Leu Ser Ala Ser Ser Glu 
             900                905                910
Asp Ile Ser Asp Arg Leu Ala Gly Val Ser Val Gly Leu Pro Ser Ser 
         915                920                925
Ala Thr Thr Glu Gln Pro Lys Pro Thr Val Gln Thr Lys Gly Arg Pro 
     930                935                940
His Ser Gln Cys Leu Asn Ser Ser Pro Leu Ser Pro Pro Gln Leu Met 
 945                950                955                960
Phe Pro Ala Ile Ser Ala Pro Cys Ser Ser Ala Pro Ser Val Pro Ala 
                 965                970                975
Gly Ser Val Thr Asp Ala Ser Lys His Arg Pro Arg Ala Phe Val Pro 
             980                985                990
Cys Lys Ile Pro Ser Ala Ser Pro Gln Thr Gln Arg Lys Phe Ser Leu 
         995                1000                1005
Gln Phe Gln Arg Thr Cys Ser Glu Asn Arg Asp Ser Glu Lys Leu Ser 
     1010                1015                1020
Pro Val Phe Thr Gln Ser Arg Pro Pro Pro Ser Ser Asn Ile His Arg 
 1025                1030                1035                1040
Ala Lys Ala Ser Arg Pro Val Pro Gly Ser Thr Ser Lys Leu Gly Asp 
                 1045                1050                1055
Ala Ser Lys Asn Ser Met Thr Leu Asp Leu Asn Ser Ala Ser Gln Cys 
             1060                1065                1070
Asp Asp Ser Phe Gly Ser Gly Ser Asn Ser Gly Ser Ala Val Ile Pro 
         1075                1080                1085
Ser Glu Glu Thr Ala Phe Thr Pro Ala Glu Asp Lys Cys Arg Leu Asp 
     1090                1095                1100
Val Asn Pro Glu Leu Asn Ser Ser Ile Glu Asp Leu Leu Glu Ala Ser 
 1105                1110                1115                1120
Met Pro Ser Ser Asp Thr Thr Val Thr Phe Lys Ser Glu Val Ala Val 
                 1125                1130                1135
Leu Ser Pro Glu Lys Ala Glu Ser Asp Asp Thr Tyr Lys Asp Asp Val 
             1140                1145                1150
Asn His Asn Gln Lys Cys Lys Glu Lys Met Glu Ala Glu Glu Glu Glu 
         1155                1160                1165
Ala Leu Ala Ile Ala Met Ala Met Ser Ala Ser Gln Asp Ala Leu Pro 
     1170                1175                1180
Ile Val Pro Gln Leu Gln Val Glu Asn Gly Glu Asp Ile Ile Ile Ile 
 1185                1190                1195                1200
Gln Gln Asp Thr Pro Glu Thr Leu Pro Gly His Thr Lys Ala Asn Glu 
                 1205                1210                1215
Pro Tyr Arg Glu Asp Thr Glu Trp Leu Lys Gly Gln Gln Ile Gly Leu 
             1220                1225                1230
Gly Ala Phe Ser Ser Cys Tyr Gln Ala Gln Asp Val Gly Thr Gly Thr 
         1235                1240                1245
Leu Met Ala Val Lys Gln Val Thr Tyr Val Arg Asn Thr Ser Ser Glu 
     1250                1255                1260
Gln Glu Glu Val Val Glu Ala Leu Arg Glu Glu Ile Arg Met Met Ser 
 1265                1270                1275                1280
His Leu Asn His Pro Asn Ile Ile Arg Met Leu Gly Ala Thr Cys Glu 
                 1285                1290                1295
Lys Ser Asn Tyr Asn Leu Phe Ile Glu Trp Met Ala Gly Ala Ser Val 
             1300                1305                1310
Ala His Leu Leu Ser Lys Tyr Gly Ala Phe Lys Glu Ser Val Val Ile 
         1315                1320                1325
Asn Tyr Thr Glu Gln Leu Leu Arg Gly Leu Ser Tyr Leu His Glu Asn 
     1330                1335                1340
Gln Ile Ile His Arg Asp Val Lys Gly Ala Asn Leu Leu Ile Asp Ser 
 1345                1350                1355                1360
Thr Gly Gln Arg Leu Arg Ile Ala Asp Phe Gly Ala Ala Ala Arg Leu 
                 1365                1370                1375
Ala Ser Lys Gly Thr Gly Ala Gly Glu Phe Gln Gly Gln Leu Leu Gly 
             1380                1385                1390
Thr Ile Ala Phe Met Ala Pro Glu Val Leu Arg Gly Gln Gln Tyr Gly 
         1395                1400                1405
Arg Ser Cys Asp Val Trp Ser Val Gly Cys Ala Ile Ile Glu Met Ala 
     1410                1415                1420
Cys Ala Lys Pro Pro Trp Asn Ala Glu Lys His Ser Asn His Leu Ala 
 1425                1430                1435                1440
Leu Ile Phe Lys Ile Ala Ser Ala Thr Thr Ala Pro Ser Ile Pro Ser 
                 1445                1450                1455
His Leu Ser Pro Gly Leu Arg Asp Val Ala Leu Arg Cys Leu Glu Leu 
             1460                1465                1470
Gln Pro Gln Asp Arg Pro Pro Ser Arg Glu Leu Leu Lys His Pro Val 
         1475                1480                1485
Phe Arg Thr Thr Trp 
     1490



<210> 8591
<211> 5234
<212> DNA
<213> Homo sapiens
<308> XM_042066
<400> 8591

cgagccctg  ggcaggcgg  ggcggagga  ccctcaagg  gagcagcgc  cccgcggct  60
ccgcgggac  gctgcggga  gcgggcagc  ggggccgcg  gcgggcgga  tggcggcgg  120
ggcagctgc  caaagtgcg  agtgtggag  tggaccagc  gcctgagca  ccgctcttc  180
ttgccgcct  accgccggc  tcctcgact  ccccgtcgc  ggagcccgc  gacgcagcg  240
ggagtggga  cggcttcca  cctgtggcg  tgccgccgc  ccacggagc  gcgagccgc  300
gcggcgccc  ccttaccga  tcggtggcg  cgccggaca  cggcgcctc  agtcccgca  360
cggccgagc  cggggagaa  cgggcgccc  ccgccgagc  gtctcctgc  gcggccccc  420
ccggtcgtg  gatggagaa  aaagaaact  tcaaagggt  gcacaagat  gatgatcgt  480
cagaggaac  aatgatcag  gagaaactg  aggcaacct  tatgccagc  tggaagcac  540
aatggttgg  aaggagaaa  aggcgaggg  ctgtggtgg  aaaaccaat  ccagttaaa  600
gagatggat  tgaaatgaa  cacttagca  ctgagtctc  aggagaggt  caggcaagt  660
cggcttcac  agcttccaa  ggccgacgc  gtccttctc  tggcaactc  ccatcaggt  720
gcacagtga  atcagaatc  ccaggagta  ggagaaaaa  agtttcccc  gtgcctttt  780
agagtggca  aatcacacc  ccccgaaga  ccccttcac  agatggctt  tcaccatat  840
gccctgagg  aacaaaccg  cgtgttaac  aagtgatgc  ggccagact  tacttactg  900
agcagatag  gcctaactc  ttcctgatt  gaggagaca  cccagacaa  aaataccgg  960
tgtttattg  gcctcagaa  tgcagctgt  cacgtggaa  attctgtat  catctgcta  1020
ttgtgatgc  ccgggtgtt  caactagaa  cttcagacc  aatgttatg  agaaaaact  1080
taaagaatt  tgaggttga  agtttgttc  agaaatatc  cagtaggcg  agctcaagg  1140
tcaaagctc  atctcgtaa  accatccag  agtttgttt  acgcatgtc  aattctcat  1200
cattgtcat  atctagtac  tctacgtct  gttcagaaa  cagcataaa  gatgaagag  1260
aacagatgt  tcctatttg  ttgttgggc  tgcttgatg  agaaagtct  acagtgtgt  1320
aagacggct  caggaacaa  ctgcaccac  actgcatgt  aatttgggc  gaagagtgt  1380
gaagaaata  agaaccttt  atatgtccc  tttgtagat  taagtggag  tctcatgat  1440
tctacagcc  cgagttgtc  agtcctgtg  attcccctt  ttccctcag  gctgcacag  1500
agcaaaccg  acagcagca  cctttggct  gatcacgaa  gaatcaaga  agcaatttt  1560
accttactc  ttatggaac  cagcaaatc  ctcctgctt  caaagattt  gctgagcca  1620
ggattcagg  gtttggaat  gaactcgtt  gctgcttat  ttctagaaa  tggaatgtg  1680
gagagatgg  cctcaggcg  ctttcccat  atgtcagtg  ggccctgct  ttggcaaat  1740
gggagagca  tggaaattc  gggggcagc  gtggaagca  cccgagtgg  ggagccacc  1800
gtgggtctt  ccagaccag  atctcagga  atgtggtgg  ggcatgctg  agcgttctg  1860
caatggtct  tgctgaccc  gtctacaaa  tgtacgttg  tgctttaaa  acattgaga  1920
ccatgctgg  atatactcc  tgccacagt  tagcggaaa  aatcaaact  cagagactt  1980
tccagccag  tgtagacac  atcctagtc  aatgtgcag  tgccaatag  cgcacaagt  2040
agctgtcca  atcaacact  ttggaactg  gcaaaggcc  agcaggaga  ttggcagtt  2100
gcagagaaa  actaaaagc  ggatccatt  gtattggtg  tgttgatta  gtcttaaat  2160
gtattcttg  aaaccaaac  gaatcaaac  attggcaag  acttcttgg  cgcctttgt  2220
ttatagata  actgttgtt  gaatttcct  ctgaatttt  tcctcatat  gtcagtact  2280
atgtttcac  agctgagcc  gttgaaatc  ggtataaga  gctgctgtc  ctcttaacc  2340
ttgctttgc  gtccattga  aattcccac  caatggttg  caaactttc  agaaggatc  2400
acttgagtt  tgcaagaat  gttactaca  taccccatg  gttttcaaa  ctgttagaa  2460
tgctgagtg  ttccagttc  actcacttc  ccaggatgc  tcgccgttt  atggctatt  2520
cagatgagg  ggaaattgc  gaagccatc  agttgggcg  agaagacac  ttggatggt  2580
aacaggaca  cttcttgca  gcatctgtt  ccaacaact  tctggaaac  acagagaac  2640
gttcccctg  gtgcacagt  catttagag  aaactggaa  aggattatg  gctacaaaa  2700
tgagtgcca  ttcagagga  atttctgag  gactggcca  catttcagt  ggaccttct  2760
gttcaacaa  aacaacaac  acaacaaca  agcaaccaa  gccaatggt  caaacaaaa  2820
gcagacccc  cagtcagtg  ttgaactcc  ctcctttat  tcatcattc  caattaatg  2880
ttccagcct  gtcaacccc  tcttcttct  ccccatctg  accagctgg  actgcaaca  2940
atgtctcta  gcatagact  cagggattc  ttccctgca  aataccttc  gcatctcct  3000
aaacacagc  caagttttc  ctacaattc  acagaaact  tcctgaaaa  aaagactca  3060
ataaacttt  cccagtctt  actcagtca  gacccttgc  ctccagtaa  atacacagg  3120
caaagccat  tagacctac  ccaggtaat  caagtaaac  gggagatcc  tcaaaaaat  3180
gcatgacac  tgatctgaa  agtagttcc  aatgtgatg  cagctttgg  tgtagcagc  3240
atagtagta  tgctgttat  cccagtgac  agacagtgt  caccccagt  gaggagaaa  3300
gcagattag  tgtcaatac  gagctcaac  ccagtattg  ggaccttct  gaagcatct  3360
tgccttcaa  tgatacaac  gtaactttt  agtcagaag  tgctgtcct  tctcctgaa  3420
aggctgaaa  tgatgatac  tacaaagat  atgtgaatc  taatcaaaa  tgcaaagag  3480
agatggaag  tgaagaaga  gaagcttta  caattgcca  ggcaatgtc  gcgtctcag  3540
atgccctcc  catagttcc  cagctgcag  ttgaaaatg  agaagatat  atcattatt  3600
aacaggata  accagagac  ctaccagga  ataccaaag  aaaacaacc  tatagagaa  3660
acactgaat  gctgaaagg  caacagata  gccttggag  attttcttc  tgttatcag  3720
ctcaagatg  gggaactgg  actttaatg  ctgttaaac  ggtgactta  gtcagaaac  3780
catcttctg  gcaagaaga  gtagtagaa  cactaagag  agagataag  atgatgagc  3840
atctgaatc  tccaaacat  attaggatg  tgggagcca  gtgtgagaa  agcaattac  3900
atctcttca  tgaatggat  gcaggggga  cggtggctc  tttgctgag  aaatatgga  3960
ccttcaaag  atcagtagt  attaactac  ctgaacagt  actccgtgg  ctttcgtat  4020
tccatgaaa  ccaaatcat  cacagagat  tcaaaggtg  caatttgct  attgacagc  4080
ctggtcaga  actaagaat  gcagatttt  gagctgcag  caggttggc  tcaaaagga  4140
ctggtgcag  agagtttca  ggacaatta  tggggacaa  tgcatttat  gcacctgag  4200
tactaagag  tcaacagta  ggaaggagc  gtgatgtat  gagtgttgg  tgtgctatt  4260
tagaaatgg  ttgtgcaaa  ccaccatgg  atgcagaaa  acactccaa  catcttgct  4320
tgatattta  ggtaattat  gctagtgca  ctactgctc  atcgatccc  tcacatttg  4380
ctcctggtt  acgagatgt  gctcttcgt  gtttagaac  tcaacctca  gacagacct  4440
catcaagag  gctactgaa  catccagtc  ttcgtacta  atggtagcc  attatgcag  4500
tcaactaca  tagaaacag  atgctcaac  agagaaaaa  aacttgtgg  gaaccacat  4560
gatattcta  tggccatga  gccactgaa  agctatgaa  gaggccagt  gggaaccct  4620
acctaagta  gtgattgac  aatcatgat  tgtacctaa  ctcagtatg  aaaagccca  4680
actagtgca  aaactgtaa  ctgtgcctt  caaagaact  gccctaggt  aacaggaaa  4740
caatgaagt  tgcatgact  aattgcaga  gcataattt  atttttttg  agcactttt  4800
cagcaatat  agcggctga  gggctcagg  tctatttta  tatttcaat  attcttcca  4860
ttcatatag  gatcacaag  agggggttc  gcaattccg  tcaaatttt  tgtcactgg  4920
tataaaatc  gtatctgcc  cttttaggt  agagtatgc  atgagtagc  atacataca  4980
atattttta  aagttgata  ttctttatg  cccacagtt  acctttatt  tcttaaata  5040
cagggcagt  gtggctcat  gtgcatttt  ctgttggcc  attcatttc  tttttggaa  5100
ttatggttt  gtattttca  gtttattta  attcatttt  gtttattca  ggaaagctg  5160
tcttttttt  aaaccagaa  aaaaaaatg  actagatat  aagtagagt  cattaaata  5220
cttgctatt  tcag  5234



<210> 8592
<211> 1351
<212> PRT
<213> Homo sapiens
<308> XP_042066
<400> 8592

Met Glu Asn Lys Glu Thr Leu Lys Gly Leu His Lys Met Asp Asp Arg 
  1               5                  10                  15
Pro Glu Glu Arg Met Ile Arg Glu Lys Leu Lys Ala Thr Cys Met Pro 
             20                  25                  30
Ala Trp Lys His Glu Trp Leu Glu Arg Arg Asn Arg Arg Gly Pro Val 
         35                  40                  45
Val Val Lys Pro Ile Pro Val Lys Gly Asp Gly Ser Glu Met Asn His 
     50                  55                  60
Leu Ala Ala Glu Ser Pro Gly Glu Val Gln Ala Ser Ala Ala Ser Pro 
 65                  70                  75                  80
Ala Ser Lys Gly Arg Arg Ser Pro Ser Pro Gly Asn Ser Pro Ser Gly 
                 85                  90                  95
Arg Thr Val Lys Ser Glu Ser Pro Gly Val Arg Arg Lys Arg Val Ser 
             100                105                110
Pro Val Pro Phe Gln Ser Gly Arg Ile Thr Pro Pro Arg Arg Ala Pro 
         115                120                125
Ser Pro Asp Gly Phe Ser Pro Tyr Ser Pro Glu Glu Thr Asn Arg Arg 
     130                135                140
Val Asn Lys Val Met Arg Ala Arg Leu Tyr Leu Leu Gln Gln Ile Gly 
 145                150                155                160
Pro Asn Ser Phe Leu Ile Gly Gly Asp Ser Pro Asp Asn Lys Tyr Arg 
                 165                170                175
Val Phe Ile Gly Pro Gln Asn Cys Ser Cys Ala Arg Gly Thr Phe Cys 
             180                185                190
Ile His Leu Leu Phe Val Met Leu Arg Val Phe Gln Leu Glu Pro Ser 
         195                200                205
Asp Pro Met Leu Trp Arg Lys Thr Leu Lys Asn Phe Glu Val Glu Ser 
     210                215                220
Leu Phe Gln Lys Tyr His Ser Arg Arg Ser Ser Arg Ile Lys Ala Pro 
 225                230                235                240
Ser Arg Asn Thr Ile Gln Lys Phe Val Ser Arg Met Ser Asn Ser His 
                 245                250                255
Thr Leu Ser Ser Ser Ser Thr Ser Thr Ser Ser Ser Glu Asn Ser Ile 
             260                265                270
Lys Asp Glu Glu Glu Gln Met Cys Pro Ile Cys Leu Leu Gly Met Leu 
         275                280                285
Asp Glu Glu Ser Leu Thr Val Cys Glu Asp Gly Cys Arg Asn Lys Leu 
     290                295                300
His His His Cys Met Ser Ile Trp Ala Glu Glu Cys Arg Arg Asn Arg 
 305                310                315                320
Glu Pro Leu Ile Cys Pro Leu Cys Arg Ser Lys Trp Arg Ser His Asp 
                 325                330                335
Phe Tyr Ser His Glu Leu Ser Ser Pro Val Asp Ser Pro Ser Ser Leu 
             340                345                350
Arg Ala Ala Gln Gln Gln Thr Val Gln Gln Gln Pro Leu Ala Gly Ser 
         355                360                365
Arg Arg Asn Gln Glu Ser Asn Phe Asn Leu Thr His Tyr Gly Thr Gln 
     370                375                380
Gln Ile Pro Pro Ala Tyr Lys Asp Leu Ala Glu Pro Trp Ile Gln Val 
 385                390                395                400
Phe Gly Met Glu Leu Val Gly Cys Leu Phe Ser Arg Asn Trp Asn Val 
                 405                410                415
Arg Glu Met Ala Leu Arg Arg Leu Ser His Asp Val Ser Gly Ala Leu 
             420                425                430
Leu Leu Ala Asn Gly Glu Ser Thr Gly Asn Ser Gly Gly Ser Ser Gly 
         435                440                445
Ser Ser Pro Ser Gly Gly Ala Thr Ser Gly Ser Ser Gln Thr Ser Ile 
     450                455                460
Ser Gly Asp Val Val Glu Ala Cys Cys Ser Val Leu Ser Met Val Cys 
 465                470                475                480
Ala Asp Pro Val Tyr Lys Val Tyr Val Ala Ala Leu Lys Thr Leu Arg 
                 485                490                495
Ala Met Leu Val Tyr Thr Pro Cys His Ser Leu Ala Glu Arg Ile Lys 
             500                505                510
Leu Gln Arg Leu Leu Gln Pro Val Val Asp Thr Ile Leu Val Lys Cys 
         515                520                525
Ala Asp Ala Asn Ser Arg Thr Ser Gln Leu Ser Ile Ser Thr Leu Leu 
     530                535                540
Glu Leu Cys Lys Gly Gln Ala Gly Glu Leu Ala Val Gly Arg Glu Ile 
 545                550                555                560
Leu Lys Ala Gly Ser Ile Gly Ile Gly Gly Val Asp Tyr Val Leu Asn 
                 565                570                575
Cys Ile Leu Gly Asn Gln Thr Glu Ser Asn Asn Trp Gln Glu Leu Leu 
             580                585                590
Gly Arg Leu Cys Leu Ile Asp Arg Leu Leu Leu Glu Phe Pro Ala Glu 
         595                600                605
Phe Tyr Pro His Ile Val Ser Thr Asp Val Ser Gln Ala Glu Pro Val 
     610                615                620
Glu Ile Arg Tyr Lys Lys Leu Leu Ser Leu Leu Thr Phe Ala Leu Gln 
 625                630                635                640
Ser Ile Asp Asn Ser His Ser Met Val Gly Lys Leu Ser Arg Arg Ile 
                 645                650                655
Tyr Leu Ser Ser Ala Arg Met Val Thr Thr Val Pro His Val Phe Ser 
             660                665                670
Lys Leu Leu Glu Met Leu Ser Val Ser Ser Ser Thr His Phe Thr Arg 
         675                680                685
Met Arg Arg Arg Leu Met Ala Ile Ala Asp Glu Val Glu Ile Ala Glu 
     690                695                700
Ala Ile Gln Leu Gly Val Glu Asp Thr Leu Asp Gly Gln Gln Asp Ser 
 705                710                715                720
Phe Leu Gln Ala Ser Val Pro Asn Asn Tyr Leu Glu Thr Thr Glu Asn 
                 725                730                735
Ser Ser Pro Glu Cys Thr Val His Leu Glu Lys Thr Gly Lys Gly Leu 
             740                745                750
Cys Ala Thr Lys Leu Ser Ala Ser Ser Glu Asp Ile Ser Glu Arg Leu 
         755                760                765
Ala Ser Ile Ser Val Gly Pro Ser Ser Ser Thr Thr Thr Thr Thr Thr 
     770                775                780
Thr Thr Glu Gln Pro Lys Pro Met Val Gln Thr Lys Gly Arg Pro His 
 785                790                795                800
Ser Gln Cys Leu Asn Ser Ser Pro Leu Ser His His Ser Gln Leu Met 
                 805                810                815
Phe Pro Ala Leu Ser Thr Pro Ser Ser Ser Thr Pro Ser Val Pro Ala 
             820                825                830
Gly Thr Ala Thr Asp Val Ser Lys His Arg Leu Gln Gly Phe Ile Pro 
         835                840                845
Cys Arg Ile Pro Ser Ala Ser Pro Gln Thr Gln Arg Lys Phe Ser Leu 
     850                855                860
Gln Phe His Arg Asn Cys Pro Glu Asn Lys Asp Ser Asp Lys Leu Ser 
 865                870                875                880
Pro Val Phe Thr Gln Ser Arg Pro Leu Pro Ser Ser Asn Ile His Arg 
                 885                890                895
Pro Lys Pro Ser Arg Pro Thr Pro Gly Asn Thr Ser Lys Gln Gly Asp 
             900                905                910
Pro Ser Lys Asn Ser Met Thr Leu Asp Leu Asn Ser Ser Ser Lys Cys 
         915                920                925
Asp Asp Ser Phe Gly Cys Ser Ser Asn Ser Ser Asn Ala Val Ile Pro 
     930                935                940
Ser Asp Glu Thr Val Phe Thr Pro Val Glu Glu Lys Cys Arg Leu Asp 
 945                950                955                960
Val Asn Thr Glu Leu Asn Ser Ser Ile Glu Asp Leu Leu Glu Ala Ser 
                 965                970                975
Met Pro Ser Ser Asp Thr Thr Val Thr Phe Lys Ser Glu Val Ala Val 
             980                985                990
Leu Ser Pro Glu Lys Ala Glu Asn Asp Asp Thr Tyr Lys Asp Asp Val 
         995                1000                1005
Asn His Asn Gln Lys Cys Lys Glu Lys Met Glu Ala Glu Glu Glu Glu 
     1010                1015                1020
Ala Leu Ala Ile Ala Met Ala Met Ser Ala Ser Gln Asp Ala Leu Pro 
 1025                1030                1035                1040
Ile Val Pro Gln Leu Gln Val Glu Asn Gly Glu Asp Ile Ile Ile Ile 
                 1045                1050                1055
Gln Gln Asp Thr Pro Glu Thr Leu Pro Gly His Thr Lys Ala Lys Gln 
             1060                1065                1070
Pro Tyr Arg Glu Asp Thr Glu Trp Leu Lys Gly Gln Gln Ile Gly Leu 
         1075                1080                1085
Gly Ala Phe Ser Ser Cys Tyr Gln Ala Gln Asp Val Gly Thr Gly Thr 
     1090                1095                1100
Leu Met Ala Val Lys Gln Val Thr Tyr Val Arg Asn Thr Ser Ser Glu 
 1105                1110                1115                1120
Gln Glu Glu Val Val Glu Ala Leu Arg Glu Glu Ile Arg Met Met Ser 
                 1125                1130                1135
His Leu Asn His Pro Asn Ile Ile Arg Met Leu Gly Ala Thr Cys Glu 
             1140                1145                1150
Lys Ser Asn Tyr Asn Leu Phe Ile Glu Trp Met Ala Gly Gly Ser Val 
         1155                1160                1165
Ala His Leu Leu Ser Lys Tyr Gly Ala Phe Lys Glu Ser Val Val Ile 
     1170                1175                1180
Asn Tyr Thr Glu Gln Leu Leu Arg Gly Leu Ser Tyr Leu His Glu Asn 
 1185                1190                1195                1200
Gln Ile Ile His Arg Asp Val Lys Gly Ala Asn Leu Leu Ile Asp Ser 
                 1205                1210                1215
Thr Gly Gln Arg Leu Arg Ile Ala Asp Phe Gly Ala Ala Ala Arg Leu 
             1220                1225                1230
Ala Ser Lys Gly Thr Gly Ala Gly Glu Phe Gln Gly Gln Leu Leu Gly 
         1235                1240                1245
Thr Ile Ala Phe Met Ala Pro Glu Val Leu Arg Gly Gln Gln Tyr Gly 
     1250                1255                1260
Arg Ser Cys Asp Val Trp Ser Val Gly Cys Ala Ile Ile Glu Met Ala 
 1265                1270                1275                1280
Cys Ala Lys Pro Pro Trp Asn Ala Glu Lys His Ser Asn His Leu Ala 
                 1285                1290                1295
Leu Ile Phe Lys Val Ile Ile Ala Ser Ala Thr Thr Ala Pro Ser Ile 
             1300                1305                1310
Pro Ser His Leu Ser Pro Gly Leu Arg Asp Val Ala Leu Arg Cys Leu 
         1315                1320                1325
Glu Leu Gln Pro Gln Asp Arg Pro Pro Ser Arg Glu Leu Leu Lys His 
     1330                1335                1340
Pro Val Phe Arg Thr Thr Trp 
 1345                1350



<210> 8593
<211> 4180
<212> DNA
<213> Rattus norvegicus
<308> U49058
<400> 8593

tgcggccgc  gctagccgg  tgggctagt  tgagccagt  cgtgagggc  cggggggcc  60
tgtcagcgc  acgcagagc  cagccgcca  caccaaacg  acatgttgg  gccccgcgc  120
gccgctgcc  cccagctct  ctccagctc  cagaactga  caggggccc  ccgcctctg  180
ctgcgctcg  ccggcccag  ctcgccgcc  cggccgcag  cccttcctg  tcggccttc  240
ccgcttgtc  cctcccgtc  tcctccccc  cacgcccta  ggccctgcc  gctcccggt  300
ctactcagc  gcggcgcga  gtctatgtg  ccggcgggc  cggagcagc  gccgccgca  360
cgcgaacat  ggacgccgt  aacgccttc  accaggagc  cttctcact  atggatatg  420
aaccaccca  ctctagagc  aagatgatt  ttattacta  agctgctat  aaagctatt  480
agctttata  gcatgttgt  caaatagta  aaaagttca  caaaaagtg  aagccagag  540
acaaggttc  aggcctgta  gtcattgac  ccatcgtga  acagtctcg  caccagttt  600
gaactgata  agatgtttt  gggccaaga  tctctgaga  tataactgc  acattccag  660
atttatatc  ttgtccatc  gaagataag  ctcacctcc  cccccagta  aagtctctt  720
tgaacttcc  caagctccc  caaactcca  gcctgctgt  ccacagctg  ccagctccg  780
tgcctttgc  gccgtggat  aactgtttc  gacgactca  ggccagcag  ttcagcaga  840
ccttcagac  tttcaacaa  ctccaaaac  acagtctcc  gcccttgac  gtgctgtga  900
ggctcaggt  caggctatc  cagctcagt  aaagacagc  cctacacaa  cacctgagc  960
aaaaactgc  tttgacaag  agctgcttg  cagatttga  tatgatgat  agccagaag  1020
tgtggaaga  tcgaagaaa  aggatgctg  cgccgttgc  accacagcc  ttgccacgg  1080
tgcacctcc  gtgcccgct  cagccacac  tgctgttgc  cctgctgtg  ctgcgtcct  1140
tgctacctc  ccccctcct  cacaggcgc  atttgggta  cctggagac  gcatgcagc  1200
gccagcgta  acacagcat  aaaatgtgg  ccagtttca  cctcgaatg  tggcactgc  1260
gcaggatag  atgcagcat  aggtcccac  tcctcctaa  ggacagatg  caggatttg  1320
gcttctctc  gcaccacct  catttcctc  catgcctca  cccgggatg  cccagcccg  1380
gatgcctca  cccgggatg  ctcagcctg  gttgtctca  cctgggttg  cccagcccg  1440
gatgcctca  cccgggatg  ctcagcccg  gatgcccca  cccgggatg  cccagcctg  1500
gttggctca  cctgggttg  cccagcccg  gatgcctca  cccgggatg  cccagcccg  1560
gatgcccca  cccgggatg  cccagcctg  aatgcctcc  actccacca  tacagccaa  1620
tttccaacc  acttttcaa  cacaaaatg  accccattc  caaaagcca  atcagcagg  1680
aatggaagt  gagcagcct  gtgtcacag  ggttaagcg  catgtgcct  agagcagaa  1740
gtcgagatc  aggtcacca  aaagaagaa  atctaggtc  ggctctagg  ctcggagat  1800
ccgccaccg  cggtctcgg  cccggtcca  ggataggcg  cggcactcg  ctcgctctc  1860
ctctcaaga  agacgggat  gagaaaaag  gagggagcg  cggcagaaa  gcctccctc  1920
gatcaagtc  gagactgca  gtgtttgca  caccacact  tgggtggga  agctggaca  1980
aaggactac  cagcaggat  ttgccagtc  cttagaaga  tttggtcca  ttgaatcaa  2040
taacatgat  cctcccagg  gctgcgcct  catagttat  gttcatagg  aagacgcat  2100
ccgtgccct  cagaaactg  gccgaggaa  ctataaagt  aaccagaaa  ccataaaga  2160
tgcctgggc  ttaaacaaa  gaataaagg  ggattttaa  cagtattgg  atgttgaac  2220
tggtgttac  tacattcca  gggacaaag  caaagctga  gagctggag  gtttctgtg  2280
aggaggcat  ttggacagt  acacactta  cccagattg  aaaggcatc  ccaaaaagc  2340
tgaaaatga  gttgcccaa  atggaggtg  agaagcctc  cacacagag  cagtgtccc  2400
catccctaa  cctgtgccc  tgcctgtgc  tgcccttcc  gttcctgca  ctataacag  2460
accacctcc  caggtccca  cgcatcagc  gggccctcc  gtcgttggt  ctctccaac  2520
gcctgcttt  actcctccc  tagggatcc  ccctccagg  tttggccct  gtgttcctc  2580
tcctcctcc  cctccacca  cattttggg  cccaggatt  aacccaatg  atttaccac  2640
aggttttct  cctcctgga  ccccacctc  tataactcc  ccagtatcc  ttcctccac  2700
tcacactcc  ccaataagc  tcccaaact  ggtgtctgg  gctagagga  atgccgagt  2760
tgctgacag  gcgaaaatg  atggttctg  tgggccacc  gctgcaccc  cgagtctgc  2820
cacccctcc  gtaacccag  ctgtttcac  gcttggcac  caaggagtt  cacctggtc  2880
tgtgattgg  ctccaggca  cctctaccg  tcttctcgg  ggcagaccc  gcctgatcc  2940
actccagcg  cccccagga  tgcctccac  acacttgca  cggttccct  tgatgccac  3000
tcggcccat  ccacctcac  tgatgcaca  gggtccgcc  ccaggacca  ggggctttg  3060
tatgcctcc  cctcatgga  tgaaagggc  tttcccacc  catggcccc  ttgttaggc  3120
tggtggaat  ccagggctt  ggggcccag  cccaggccc  ggaggatca  aagacagag  3180
tggaaggca  cagcaaccg  agcagcagc  gcagcagca  cagcagcag  agcagcagc  3240
gcagcagca  cagcagcaa  caccaccac  gcagtcaca  acacagcag  agccagcgc  3300
atcccagca  ccagcgcca  ctcagcagc  gccacagca  tttagaaat  ataacaggc  3360
gcagttcaa  tcaggtaga  accaagaaa  gtttggaag  agatctttt  gaagtaggg  3420
ggaaaatga  cgggagcgg  atgggagcc  tagtgatga  agagataat  gcaaccgtg  3480
aaggagaga  tggggaagg  ggagccctg  gcgggacag  cacagagac  tggaagaga  3540
aagtagacg  tctagtggg  atcgggaca  agacaggga  tctagagat  gagagtccc  3600
tagagagaa  gaagaaagt  gaggaaagg  gaagcacga  gtggcagac  gggcaggtg  3660
taacaaagc  gtcgaagct  cccttagcc  agtgggaaa  acagacact  tttcagaac  3720
taataaggg  gaggccatg  ccacagtgg  aaaacctga  gagtcacct  ctgaggcta  3780
ctcatccgt  gaacctgag  aggattctg  ctcagcagc  gaggctcct  gctagagac  3840
ggatttgac  gaatgtgac  gtgacactt  ggtgtagaa  gtgaggtgt  cagatgctg  3900
ataatattc  ctcctgcta  atcactcca  agtagttgg  ggggattgt  agcaatttg  3960
ttgctttcc  tctatttaa  aatagccac  aaataacaa  aaatactga  gatatatta  4020
ccctttttt  gctgtaact  tttaaaagt  ttgactttt  aaagtttac  aatcctaat  4080
agaagtgct  tctattttt  ttttttaat  taagaaaag  taacggtga  aagctcctc  4140
aacaatagg  atgttttta  taaactcta  tttcgtaacc  4180



<210> 8594
<211> 1703
<212> DNA
<213> Rattus norvegicus
<308> U49062
<400> 8594

ggcacgagt  tccacgcac  ggagcatcc  gagagtcgc  gcgcgccga  ggagcggac  60
tgggcagag  gatggtggt  aggctaggg  tggggttgc  gcttctggc  ctgctccta  120
ccacgcaga  ttattgcaa  caaacatcg  ttgcaccat  ttccgggaa  cagagtatc  180
ctgctgccc  aaatccaac  aatgctacc  ccagatctg  gtgtagctc  ctgcagtcc  240
cagccggtc  cctggccct  tctctctct  tcctacatc  ctactgtta  agactcagg  300
caagaaacg  ctctacttc  ccatctaga  ccaccccga  tggcaacca  aagtccaat  360
tgagtgacc  ggaagagac  ggtccacat  aaatcggct  ttaccatta  ctcaacaga  420
aacactgag  atccgaaat  cgactggct  aaaggacgc  tgaagggtt  gagagctga  480
agatgccaa  atgggatct  ctggagttt  atgtccgag  tgaagacaa  catccaaaa  540
tgacgtgat  tgctcgaaa  gtggcttaa  aaatgtgga  acttaaaac  ctcactcga  600
atcgggcgt  ggtttgatg  agagggaga  ggatggggt  tggaatgga  gtccattat  660
ttcattggt  ccttcgacc  ataaggcca  aatgcagtt  ggtggtatt  aaaagcttc  720
ctgatgcta  ttctgtgta  gttggaagg  actaccagg  gttatttta  atccccgat  780
tgttgtttt  ttactacta  tttaatagg  taaactcta  gtgaagtcc  acgtcgttg  840
cctctagtt  ttctctccg  aacagaacg  tttacaccc  ccttctgtg  ctttaggtc  900
cccaccccc  aatccagcc  cccctgagt  aatctgatt  caaaagtca  aacggcaaa  960
catttccca  tgtcttttc  cactcacca  gggtactaa  ttcacttag  tgagctggt  1020
ctccagaga  cagaattct  ttgatctcg  ctaatctcc  aacgctgcg  tttattttg  1080
catatgtcg  gggcttttc  tgatttaaa  cgtggtctg  tagcaaggc  aaaattatg  1140
gtcttgaaa  tctacaggc  aatatgcaa  ccagcattt  ggatgtgag  actggaagc  1200
ctcacagaa  tacacaaag  cttttatac  atttctgta  atacttttt  ttttttaaa  1260
agaaaaaca  aaccatgga  cggaataac  acgtttgga  tactttggt  atcagttca  1320
atttttaga  agtttgaca  tggtcctgt  cctgagagg  ggtttggtt  tacagtaag  1380
ttttttttc  cccaatttc  ttgatacac  cataccttc  aaaacacag  catttcctc  1440
aaaaaaaaa  aaaattcct  ttgttcgca  ggtcacaca  tgatgcttg  cattctggg  1500
tctaatacg  tcacagtag  cttgataac  agaatcatt  ttttctccg  ctttagaaa  1560
ctacccggg  acaaggaga  ctcacagac  cgaagctac  gtgtgtgtg  atgaacact  1620
cccttgcct  atacccgaa  gctgtacat  tatttgatt  tatattgtg  ttgtgtatt  1680
taaataaaa  aaagaaatg  ctg  1703



<210> 8595
<211> 76
<212> PRT
<213> Rattus norvegicus
<308> Q07490
<400> 8595

Met Gly Arg Ala Met Val Val Arg Leu Gly Leu Gly Leu Leu Leu Leu 
  1               5                  10                  15
Ala Leu Leu Leu Pro Thr Gln Ile Tyr Cys Asn Gln Thr Ser Val Ala 
             20                  25                  30
Pro Phe Ser Gly Asn Gln Ser Ile Ser Ala Ala Pro Asn Pro Thr Asn 
         35                  40                  45
Ala Thr Thr Arg Ser Gly Cys Ser Ser Leu Gln Ser Thr Ala Gly Leu 
     50                  55                  60
Leu Ala Leu Ser Leu Ser Leu Leu His Leu Tyr Cys 
 65                  70                  75



<210> 8596
<211> 284
<212> DNA
<213> Homo sapiens
<308> AI860750
<400> 8596

ttttttttt  ttttttttt  ttttttttt  ttttttttt  tggcccttt  aaccatttt  60
ttttattta  aggtggggg  caaggcaaa  caattccat  aaaagttac  atgaatcaa  120
gcgtaaata  ccaaaccca  tttacaatc  aaaataaat  tccagcatt  tggaataaa  180
caagagggg  cattccccc  ccccagnng  ttcaaaact  gtcgatctg  ttggtccca  240
ggggttttc  aaaaaagga  aaaaaggac  ttgggcatc  aaac  284



<210> 8597
<211> 1703
<212> DNA
<213> Rattus norvegicus
<308> U49062
<400> 8597

ggcacgagt  tccacgcac  ggagcatcc  gagagtcgc  gcgcgccga  ggagcggac  60
tgggcagag  gatggtggt  aggctaggg  tggggttgc  gcttctggc  ctgctccta  120
ccacgcaga  ttattgcaa  caaacatcg  ttgcaccat  ttccgggaa  cagagtatc  180
ctgctgccc  aaatccaac  aatgctacc  ccagatctg  gtgtagctc  ctgcagtcc  240
cagccggtc  cctggccct  tctctctct  tcctacatc  ctactgtta  agactcagg  300
caagaaacg  ctctacttc  ccatctaga  ccaccccga  tggcaacca  aagtccaat  360
tgagtgacc  ggaagagac  ggtccacat  aaatcggct  ttaccatta  ctcaacaga  420
aacactgag  atccgaaat  cgactggct  aaaggacgc  tgaagggtt  gagagctga  480
agatgccaa  atgggatct  ctggagttt  atgtccgag  tgaagacaa  catccaaaa  540
tgacgtgat  tgctcgaaa  gtggcttaa  aaatgtgga  acttaaaac  ctcactcga  600
atcgggcgt  ggtttgatg  agagggaga  ggatggggt  tggaatgga  gtccattat  660
ttcattggt  ccttcgacc  ataaggcca  aatgcagtt  ggtggtatt  aaaagcttc  720
ctgatgcta  ttctgtgta  gttggaagg  actaccagg  gttatttta  atccccgat  780
tgttgtttt  ttactacta  tttaatagg  taaactcta  gtgaagtcc  acgtcgttg  840
cctctagtt  ttctctccg  aacagaacg  tttacaccc  ccttctgtg  ctttaggtc  900
cccaccccc  aatccagcc  cccctgagt  aatctgatt  caaaagtca  aacggcaaa  960
catttccca  tgtcttttc  cactcacca  gggtactaa  ttcacttag  tgagctggt  1020
ctccagaga  cagaattct  ttgatctcg  ctaatctcc  aacgctgcg  tttattttg  1080
catatgtcg  gggcttttc  tgatttaaa  cgtggtctg  tagcaaggc  aaaattatg  1140
gtcttgaaa  tctacaggc  aatatgcaa  ccagcattt  ggatgtgag  actggaagc  1200
ctcacagaa  tacacaaag  cttttatac  atttctgta  atacttttt  ttttttaaa  1260
agaaaaaca  aaccatgga  cggaataac  acgtttgga  tactttggt  atcagttca  1320
atttttaga  agtttgaca  tggtcctgt  cctgagagg  ggtttggtt  tacagtaag  1380
ttttttttc  cccaatttc  ttgatacac  cataccttc  aaaacacag  catttcctc  1440
aaaaaaaaa  aaaattcct  ttgttcgca  ggtcacaca  tgatgcttg  cattctggg  1500
tctaatacg  tcacagtag  cttgataac  agaatcatt  ttttctccg  ctttagaaa  1560
ctacccggg  acaaggaga  ctcacagac  cgaagctac  gtgtgtgtg  atgaacact  1620
cccttgcct  atacccgaa  gctgtacat  tatttgatt  tatattgtg  ttgtgtatt  1680
taaataaaa  aaagaaatg  ctg  1703



<210> 8598
<211> 76
<212> PRT
<213> Rattus norvegicus
<308> Q07490
<400> 8598

Met Gly Arg Ala Met Val Val Arg Leu Gly Leu Gly Leu Leu Leu Leu 
  1               5                  10                  15
Ala Leu Leu Leu Pro Thr Gln Ile Tyr Cys Asn Gln Thr Ser Val Ala 
             20                  25                  30
Pro Phe Ser Gly Asn Gln Ser Ile Ser Ala Ala Pro Asn Pro Thr Asn 
         35                  40                  45
Ala Thr Thr Arg Ser Gly Cys Ser Ser Leu Gln Ser Thr Ala Gly Leu 
     50                  55                  60
Leu Ala Leu Ser Leu Ser Leu Leu His Leu Tyr Cys 
 65                  70                  75



<210> 8599
<211> 284
<212> DNA
<213> Homo sapiens
<308> AI860750
<400> 8599

ttttttttt  ttttttttt  ttttttttt  ttttttttt  tggcccttt  aaccatttt  60
ttttattta  aggtggggg  caaggcaaa  caattccat  aaaagttac  atgaatcaa  120
gcgtaaata  ccaaaccca  tttacaatc  aaaataaat  tccagcatt  tggaataaa  180
caagagggg  cattccccc  ccccagnng  ttcaaaact  gtcgatctg  ttggtccca  240
ggggttttc  aaaaaagga  aaaaaggac  ttgggcatc  aaac  284



<210> 8600
<211> 2412
<212> DNA
<213> Rattus norvegicus
<308> U49099
<400> 8600

ggcacgagg  tggcggcgg  aaccagcaa  tactgggaa  atcttagga  acaagctcg  60
cagctggaa  atgaacttg  cctgaaact  gtttccttc  gtaaactgt  tacgagtta  120
agtcacagc  gcgcccggg  tggaggccg  gataggtat  gttctgaca  aacacccct  180
ttaaatgga  caagccaag  caggatgtt  gagacaatg  ccattgaaa  tgaacagct  240
ttggcgagg  ttacaggag  aaacgacaa  atggcagag  atactcaca  tgcaggggt  300
ccctccctg  acgcagccc  gatgcacac  ctacagcga  acagagaca  tctgcagga  360
tatacacat  aattccata  aaccaaagc  aactttatg  caatacggg  aagggagaa  420
ctcatggga  cagtacgaa  agatattga  tcatataaa  gtgggtctg  agtaaacaa  480
aggagaact  aactgtttc  gaaagaaca  gaccacctt  gaaactctg  tcgtctgat  540
gaagagaca  taagcattg  tatggcaac  aaagagaat  tgacttcgc  gagaggaat  600
ctcaagtcc  ttcacagca  gatgaacac  ctggccaac  gctttcccg  cgtcaacag  660
ctgatacaa  ggatcaacc  taggaagcg  cgcgactcg  tcatccttg  aggcgtcat  720
ggcatctgc  ccatcctgt  gctgctgta  gcattccac  gagaggtcg  ccccaggac  780
ctgcccacc  tctgcggcc  gctttggca  tggggaacc  gcaaaggag  gagaccgtc  840
ggccatgag  ctgccagca  atgaattct  aactgcacc  tggctctga  ctggtcggc  900
tgagctgaa  ccacagttt  tctgtgcct  tcttttcta  tacatatta  tctgttttt  960
attttaaaa  caacaaaag  tttcagttg  tgcatctcc  taggaggta  gcaagcaga  1020
gctgagaac  tgggcttta  tgactggtg  agccagatg  ccagcgggc  tcatagctg  1080
actcctcac  gcaccaggc  ctacatcca  agatggcct  actttcagc  acgagattg  1140
atgtgaata  aaataattc  tgtcctttt  tttaacact  gtgatgaga  gtcagctgt  1200
ctttgctga  actccgtga  ccaatcgcg  attctgtgt  cctaatctc  tggcagtca  1260
gaaaaattc  atttcccac  gattctgta  gatgttggt  ggccagctt  atgtttgag  1320
cggtctgaa  tggaaagtg  tatagaaag  gtgtctctt  tctgtttca  ttgtgagcc  1380
tgggtcaac  actgccacc  gcacatcag  atggcgggc  ttacagagg  gctggtcat  1440
gctttatta  ttcttccct  gggctgata  ttgcttgta  tgataaaaa  gcatttcca  1500
tgatagccc  tcagtgact  tcatcggcc  tcgaagtcc  atatcatgt  aagcttaat  1560
ctaggaact  aaggaggga  ttggttctc  gtgaggcct  ctcgtgagc  actgctgtg  1620
gggttggga  gataaaatt  tgttttggg  tttggtggt  ggagattat  ttggagttg  1680
tgttggttg  gaatgtggt  agggatata  agtaaatta  tcgagtata  aagaatagg  1740
ttaataggg  tatgatagc  attagtgtt  atagggttg  gcagttgtt  tttagaagc  1800
cggagataa  tgctcattt  ggtaaaaat  ctgtgagag  ggggagtcc  cctagtgat  1860
ggaggatga  ggatgctat  gttaggatt  tgggagttt  atttcatgc  agtgagagt  1920
tgttgattg  tgttgctga  tttgttatg  gtgtaatga  tattggaac  gtaagtagg  1980
tgtaaattg  taagtttag  agggttaag  tagggttgt  tggaaggat  gctgttatt  2040
atcctatgt  ggcaattga  gagtatgct  tgcattttt  gtgtttggg  ctggttaag  2100
cctcctcag  cgccaacaa  gactgatga  attgcgaga  tggtggtga  agttgggtt  2160
aggagttga  aaaattggt  tagaattga  agtggagca  ttttttgtc  tgttagtaa  2220
attaatcca  tgtgtaggg  aattccttg  gtgacttcg  gtagtcagt  gtggaatgg  2280
gctagtcca  gttttatgg  tagtgaaat  agtattatg  tgagtagta  gttattggt  2340
tgttgttgg  gggttcata  tcctgattg  ttgtagttg  ggatgatga  tagtaggat  2400
attctcgtg  cg  2412



<210> 8601
<211> 250
<212> PRT
<213> Rattus norvegicus
<308> Q62931
<400> 8601

Met Ala Ala Gly Thr Ser Asn Tyr Trp Glu Asp Leu Arg Lys Gln Ala 
  1               5                  10                  15
Arg Gln Leu Glu Asn Glu Leu Asp Leu Lys Leu Val Ser Phe Ser Lys 
             20                  25                  30
Leu Cys Thr Ser Tyr Ser His Ser Ser Ala Arg Asp Gly Gly Arg Asp 
         35                  40                  45
Arg Tyr Ser Ser Asp Thr Thr Pro Leu Leu Asn Gly Ser Ser Gln Asp 
     50                  55                  60
Arg Met Phe Glu Thr Met Ala Ile Glu Ile Glu Gln Leu Leu Ala Arg 
 65                  70                  75                  80
Leu Thr Gly Val Asn Asp Lys Met Ala Glu Tyr Thr His Ser Ala Gly 
                 85                  90                  95
Val Pro Ser Leu Asn Ala Ala Leu Met His Thr Leu Gln Arg His Arg 
             100                105                110
Asp Ile Leu Gln Asp Tyr Thr His Glu Phe His Lys Thr Lys Ala Asn 
         115                120                125
Phe Met Ala Ile Arg Glu Arg Glu Asn Leu Met Gly Ser Val Arg Lys 
     130                135                140
Asp Ile Glu Ser Tyr Lys Ser Gly Ser Gly Val Asn Asn Arg Arg Thr 
 145                150                155                160
Glu Leu Phe Leu Lys Glu His Asp His Leu Arg Asn Ser Asp Arg Leu 
                 165                170                175
Ile Glu Glu Thr Ile Ser Ile Ala Met Ala Thr Lys Glu Asn Met Thr 
             180                185                190
Ser Gln Arg Gly Met Leu Lys Ser Ile His Ser Lys Met Asn Thr Leu 
         195                200                205
Ala Asn Arg Phe Pro Ala Val Asn Ser Leu Ile Gln Arg Ile Asn Leu 
     210                215                220
Arg Lys Arg Arg Asp Ser Leu Ile Leu Gly Gly Val Ile Gly Ile Cys 
 225                230                235                240
Thr Ile Leu Leu Leu Leu Tyr Ala Phe His 
                 245                250



<210> 8602
<211> 999
<212> DNA
<213> Homo sapiens
<308> AF073926
<400> 8602

gcacgagca  agatggcgg  agggaccag  agttactgg  aagatctca  gaaacaggc  60
cgacagctg  aaaatgaac  tgacctgaa  ctagtttcc  tcagcaaac  atgtacaag  120
tacagtcat  gcagtaccc  agatggaag  cgcgacagg  atagttctg  tacaacacc  180
cttttaaat  gatcaagcc  agacagaat  tttgagaca  tggcgattg  gattgaaca  240
cttttggca  ggcttacag  ggtaaatga  aaaatggca  aatatacca  cagtgcagg  300
gtcccctcc  tgaatgcag  cctgatgca  acattacag  ggcatagag  catattgca  360
gattataca  atgaattcc  taaaaccaa  gcaaacttt  tggcaatac  ggaaaggga  420
aatcttatg  gatcagtac  aaaagatat  gagtcatat  aaagtgggt  tggagtaaa  480
aacagaaga  ctgagctat  tttgaaaga  catgaccac  ttcgaaact  agatcgtct  540
atagaagag  caataagca  tgctatggc  acaaaagaa  atatgactt  acagagagg  600
atgttgaag  caattcaca  caaaatgaa  actttggcc  atcgttttc  tgctgtaaa  660
agcctgatc  agaggatca  cctgaggaa  cggcgggac  cgctcatcc  agggggtgt  720
attgggatc  gtaccatcc  gttgctgct  tatgcgttc  attgatggg  catcttcag  780
gactcttga  agccaccgc  ttcacaccc  ggtctggaa  aaggaaaca  cggagggag  840
agttgactg  cttgataat  agcctgacc  gcaggatga  tgcaagact  acagtgatg  900
actctgtga  atggtcagg  tgagctgaa  ccacagttt  tctgtgctg  gttttctaa  960
acatttttc  gtttttaat  aaaaaaaaa  aaaaaaaaa  999



<210> 8603
<211> 250
<212> PRT
<213> Homo sapiens
<308> O95249
<400> 8603

Met Ala Ala Gly Thr Ser Ser Tyr Trp Glu Asp Leu Arg Lys Gln Ala 
  1               5                  10                  15
Arg Gln Leu Glu Asn Glu Leu Asp Leu Lys Leu Val Ser Phe Ser Lys 
             20                  25                  30
Leu Cys Thr Ser Tyr Ser His Ser Ser Thr Arg Asp Gly Arg Arg Asp 
         35                  40                  45
Arg Tyr Ser Ser Asp Thr Thr Pro Leu Leu Asn Gly Ser Ser Gln Asp 
     50                  55                  60
Arg Met Phe Glu Thr Met Ala Ile Glu Ile Glu Gln Leu Leu Ala Arg 
 65                  70                  75                  80
Leu Thr Gly Val Asn Asp Lys Met Ala Glu Tyr Thr Asn Ser Ala Gly 
                 85                  90                  95
Val Pro Ser Leu Asn Ala Ala Leu Met His Thr Leu Gln Arg His Arg 
             100                105                110
Asp Ile Leu Gln Asp Tyr Thr His Glu Phe His Lys Thr Lys Ala Asn 
         115                120                125
Phe Met Ala Ile Arg Glu Arg Glu Asn Leu Met Gly Ser Val Arg Lys 
     130                135                140
Asp Ile Glu Ser Tyr Lys Ser Gly Ser Gly Val Asn Asn Arg Arg Thr 
 145                150                155                160
Glu Leu Phe Leu Lys Glu His Asp His Leu Arg Asn Ser Asp Arg Leu 
                 165                170                175
Ile Glu Glu Thr Ile Ser Ile Ala Met Ala Thr Lys Glu Asn Met Thr 
             180                185                190
Ser Gln Arg Gly Met Leu Lys Ser Ile His Ser Lys Met Asn Thr Leu 
         195                200                205
Ala Asn Arg Phe Pro Ala Val Asn Ser Leu Ile Gln Arg Ile Asn Leu 
     210                215                220
Arg Lys Arg Arg Asp Ser Leu Ile Leu Gly Gly Val Ile Gly Ile Cys 
 225                230                235                240
Thr Ile Leu Leu Leu Leu Tyr Ala Phe His 
                 245                250



<210> 8604
<211> 2539
<212> DNA
<213> Rattus norvegicus
<308> U49953
<400> 8604

cccgggcgg  aggtaccgc  gcacggtgg  cgctcctca  cgcttcccc  cacctccca  60
tcccactgc  cctctaggc  gcgcggagt  ctctcggct  ttaccggct  tttggagcc  120
cctgtgccc  ctcagagcc  gcgctctcc  cagtctcct  agagaagga  cccctcaga  180
agcgcaccc  gccccttcg  agtccgggc  cgcctcccg  tccccgcgg  ccgcagcgt  240
ccgccctcc  gagcccggc  cgagcggcg  gaggagaac  cggggctgc  gcccgcgca  300
actcccgcg  tctctctgg  tttggctgc  gccaggagg  ggaggagcg  agcgagcgc  360
gaagtagct  ctgctgctg  tggtgacaa  gtcaaataa  ggcttagac  tccaggaca  420
acccccagc  cctccgatg  gaaacacca  cactatgat  ggagctggc  gcaaagacc  480
tggaaccct  aaccacggt  ccaaacctc  gcctccaaa  ccagaggag  agaaaaaga  540
ggaccggtt  tatcgatcc  tcttagctg  agataaaac  aataaaaag  aggagaagg  600
gcggccaga  atttctctt  cttcagatt  tgagcatac  attcatgtt  gttttgatg  660
tgtcacagg  gagtttacg  ggatgccag  acagtgggc  cgcttgctt  aaacatcaa  720
tatcaccaa  tcagagcag  agaaaaacc  acaggctgt  ctggatgtg  tggaatttt  780
taactccaa  aagacctcc  atagtcaga  gtacatgag  tttacagat  agtcagctg  840
agattataa  tcttctaat  ctttgaatg  gaagactgt  tctgagacc  cagcagtgc  900
accagtgtc  gaagatgaa  atgatgatg  cgatgctac  ccacctcca  tgattgctc  960
acgcccaga  cacacaaaa  ctgtatata  acggtctgt  attgaacca  ttcctgtta  1020
tccaactcg  gatgtggct  catctccta  ttctcctac  gagaataac  ccactccgc  1080
agatgcttt  acccggaat  ctgaaaagc  gaagaagaa  cctaaaatg  ctgatgagg  1140
gatcttaga  aaattacgg  gcatagtga  tgtgggcga  cctaagaag  agtacacac  1200
cttcgagaa  attggacaa  gtgcttcag  cacagtgta  actgcaatg  atgtagcca  1260
agggcagga  gtggccatt  aacagatga  ccttcagca  cagccgaag  aagaactca  1320
tattaatga  atcctggtc  tgagggaaa  caaaaaccc  aacattgtg  actatctgg  1380
cagttacct  gtgggagat  agctatggg  tgtcatgga  tacttggcc  gaggctcct  1440
aacagatgt  gtgacagaa  cctgtatgg  tgaaggcca  atagcagct  tgtgccgag  1500
gtgtctaca  gctttggag  tcctgcatt  aaaccaagt  attcacaga  acatcaaga  1560
tgacaatat  ctgctggga  tggatggct  tgtcaaatt  actgacttt  gattctgtg  1620
acagataac  ccagagcag  gcaaaagga  caccatggt  ggaactcca  attggatgg  1680
acctgaagt  gtgacacgc  aggcctatg  acccaaggt  gacatctgg  ccctgggta  1740
tatggcaat  gaaatgatt  agggggagc  cccatacct  aatgaaaac  ctttgagag  1800
cttgtacct  attgctacc  atgggacgc  agagcttca  aacccagag  agttgtcag  1860
tattttccg  gactttttg  accgctgtc  tgagatgga  gtggagaag  gaggttcag  1920
taaagagct  ctgcagcat  aattcctga  gattgccaa  cctctctcc  gcctgactc  1980
actgattgc  gcagcaaaa  aggcaacca  gaacaatca  tgaaaccac  ctcacccca  2040
cctcatgtg  caagccttc  atgaaataa  cactcgttt  gggaactcc  acccctcat  2100
tcctcttct  ctttccttg  ttctcccat  tcctgatct  gtgctctca  gactttgat  2160
cttggaaac  gtctagcac  gaagagaac  gcaaccgga  gactaatcc  gcagaggcc  2220
tttctaaat  ggaattccc  ttagcttgt  ggcatggag  ggactgatg  gcaagggtt  2280
acctgaata  acctgtttc  acgaaacag  aatctcaac  atcccattc  ttacccctc  2340
caatcagtt  ttaactcta  aaacttatg  tttgatagc  ttatcaatt  gctatcagt  2400
gaaattgct  ttgtttttt  tttctgtga  caaattgcc  aaacacttc  ttgtatttg  2460
aaaccagaa  agctttgaa  tgccacggg  cctgataat  tgccaggga  atgaagagg  2520
cttgtttcc  tgaacccac  2539



<210> 8605
<211> 544
<212> PRT
<213> Rattus norvegicus
<308> P35465
<400> 8605

Met Ser Asn Asn Gly Leu Asp Val Gln Asp Lys Pro Pro Ala Pro Pro 
  1               5                  10                  15
Met Arg Asn Thr Ser Thr Met Ile Gly Ala Gly Ser Lys Asp Pro Gly 
             20                  25                  30
Thr Leu Asn His Gly Ser Lys Pro Leu Pro Pro Asn Pro Glu Glu Lys 
         35                  40                  45
Lys Lys Lys Asp Arg Phe Tyr Arg Ser Ile Leu Ala Gly Asp Lys Thr 
     50                  55                  60
Asn Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Leu Pro Ser Asp 
 65                  70                  75                  80
Phe Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe 
                 85                  90                  95
Thr Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile 
             100                105                110
Thr Lys Ser Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu 
         115                120                125
Glu Phe Tyr Asn Ser Lys Lys Thr Ser Asn Ser Gln Lys Tyr Met Ser 
     130                135                140
Phe Thr Asp Lys Ser Ala Glu Asp Tyr Asn Ser Ser Asn Thr Leu Asn 
 145                150                155                160
Val Lys Thr Val Ser Glu Thr Pro Ala Val Pro Pro Val Ser Glu Asp 
                 165                170                175
Glu Asp Asp Asp Asp Asp Ala Thr Pro Pro Pro Val Ile Ala Pro Arg 
             180                185                190
Pro Glu His Thr Lys Ser Val Tyr Thr Arg Ser Val Ile Glu Pro Leu 
         195                200                205
Pro Val Thr Pro Thr Arg Asp Val Ala Thr Ser Pro Ile Ser Pro Thr 
     210                215                220
Glu Asn Asn Thr Thr Pro Pro Asp Ala Leu Thr Arg Asn Thr Glu Lys 
 225                230                235                240
Gln Lys Lys Lys Pro Lys Met Ser Asp Glu Glu Ile Leu Glu Lys Leu 
                 245                250                255
Arg Ser Ile Val Ser Val Gly Asp Pro Lys Lys Lys Tyr Thr Arg Phe 
             260                265                270
Glu Lys Ile Gly Gln Gly Ala Ser Gly Thr Val Tyr Thr Ala Met Asp 
         275                280                285
Val Ala Thr Gly Gln Glu Val Ala Ile Lys Gln Met Asn Leu Gln Gln 
     290                295                300
Gln Pro Lys Lys Glu Leu Ile Ile Asn Glu Ile Leu Val Met Arg Glu 
 305                310                315                320
Asn Lys Asn Pro Asn Ile Val Asn Tyr Leu Asp Ser Tyr Leu Val Gly 
                 325                330                335
Asp Glu Leu Trp Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr 
             340                345                350
Asp Val Val Thr Glu Thr Cys Met Asp Glu Gly Gln Ile Ala Ala Val 
         355                360                365
Cys Arg Glu Cys Leu Gln Ala Leu Glu Phe Leu His Ser Asn Gln Val 
     370                375                380
Ile His Arg Asp Ile Lys Ser Asp Asn Ile Leu Leu Gly Met Asp Gly 
 385                390                395                400
Ser Val Lys Leu Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu 
                 405                410                415
Gln Ser Lys Arg Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro 
             420                425                430
Glu Val Val Thr Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser 
         435                440                445
Leu Gly Ile Met Ala Ile Glu Met Ile Glu Gly Glu Pro Pro Tyr Leu 
     450                455                460
Asn Glu Asn Pro Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr 
 465                470                475                480
Pro Glu Leu Gln Asn Pro Glu Lys Leu Ser Ala Ile Phe Arg Asp Phe 
                 485                490                495
Leu Asn Arg Cys Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala Lys 
             500                505                510
Glu Leu Leu Gln His Gln Phe Leu Lys Ile Ala Lys Pro Leu Ser Ser 
         515                520                525
Leu Thr Pro Leu Ile Ala Ala Ala Lys Glu Ala Thr Lys Asn Asn His 
     530                535                540



<210> 8606
<211> 1975
<212> DNA
<213> Rattus norvegicus
<308> U50185
<400> 8606

cgcgagcag  tgaagcgct  gatcggctc  gagacggac  tcgagcctc  cgtggtgaa  60
cgccagaag  ccaaggtga  gttcgacga  ggcgccgtc  tcctcgccg  ctgctccag  120
ggcgacacg  acgaggtcc  caagctgct  caccgcggc  ccgacatca  ttacgccaa  180
gtggacgga  tcaccgccc  gcaccaggc  tgcattgat  acaatgttg  tatggtgaa  240
tttctggta  aaaatggag  aaatatcaa  caacctgac  atgaaggct  gattccact  300
catgcagcc  cttcctgtg  atatctgga  attgcagaa  ttttgattg  tcaaggagc  360
catgtagga  ctgtcaaca  tgaaggtga  acaccttta  atattgcag  ggaggaagc  420
atggaagag  tacttcaaa  tgaggttaa  cggcaaggt  ttgatatag  agcagctcg  480
aaagaagag  aacgcataa  gcttagaga  gcgaggcag  ggttgaaca  tggtcacat  540
agtgacgtc  ggcatgcaa  gtccggagg  acagcactc  acgtggcag  ggccaaagg  600
tatacagaa  ttttaaaac  tttaataca  gcaggctat  atgttaata  taaagatta  660
gatggctgg  cacctcttc  tgctgcagc  cactggggt  aagaagaag  atgtcggat  720
ttagtggac  atctgtgtg  tatggagac  gtcaacaaa  tgggccaaa  agcctttga  780
gtagcagat  aagacattt  gggatatct  gaggagttg  aaaaaaaac  aaatctgct  840
catagtgaa  agcgggata  gaaatctcc  ctgattgaa  caacagcaa  tatggaaaa  900
aatcaacca  agaagaatt  taaaaacaa  gaaacgttg  ttattgagc  agagaaaaa  960
gcatctcga  tcgagtctc  ggagcaaga  aaggctgat  aggaggagg  aggcaagaa  1020
gatgagtcc  gctgctcca  tgaggagga  gaggaggat  actccgagt  cgaagcgga  1080
acagataag  caaaaccca  ggcttctgt  actaatgct  acactgcca  cactcaggc  1140
gctcctgcc  ctgtgacaa  acctactct  tcttccaac  aggggaccc  tacatcacc  1200
gttaaaaag  ttcctacat  aactacaaa  atttctccc  aagaagaag  aagaaaaga  1260
gaatctcct  catcctgga  gttaggact  agaaagact  gcagttatg  tgccctggc  1320
gagatcact  catctaaag  agctcagaa  gagaaagac  ctgcaggcg  gatacgttc  1380
gcttcgagt  ccagactct  gtcctcttt  gataataaa  aaaaggaga  agacaataa  1440
ggaacaaga  ttgcatatg  cgcccctac  atcccaagg  gactaggca  tacgtctga  1500
attgaagag  aggaaaaca  agagtcttc  aatttgcga  caagtagtt  ttacacaag  1560
agaaaatgg  aagatgatc  taaaaaaaa  agttcaatc  atgaaggat  tacttacca  1620
agaagttgc  cctttggta  aagacaaga  gatttgatt  gttgtagtg  tccaagcac  1680
acatcaaca  caacagtta  ctctccagc  gggcttcag  aaagcttcc  ttccagcac  1740
agcactact  caaagactc  cccgggttc  tccccagca  gcacacaga  caggtcata  1800
ctcactcct  ttagggatg  agagtctga  tcccacagg  aagcaagat  tagacaagc  1860
agacagtct  gacggtcaa  acagggggt  acactgact  acctccagg  agccgaaaa  1920
acaatagga  gaagccgtt  tacgagaac  agagaacaa  aaaacgaag  aaaag  1975



<210> 8607
<211> 658
<212> PRT
<213> Rattus norvegicus
<308> AAA92961
<400> 8607

Arg Glu Gln Leu Lys Arg Trp Ile Gly Ser Glu Thr Asp Leu Glu Pro 
  1               5                  10                  15
Pro Val Val Lys Arg Gln Lys Thr Lys Val Lys Phe Asp Asp Gly Ala 
             20                  25                  30
Val Phe Leu Ala Ala Cys Ser Ser Gly Asp Thr Asp Glu Val Leu Lys 
         35                  40                  45
Leu Leu His Arg Gly Ala Asp Ile Asn Tyr Ala Asn Val Asp Gly Leu 
     50                  55                  60
Thr Ala Leu His Gln Ala Cys Ile Asp Asp Asn Val Asp Met Val Lys 
 65                  70                  75                  80
Phe Leu Val Glu Asn Gly Ala Asn Ile Asn Gln Pro Asp Asn Glu Gly 
                 85                  90                  95
Trp Ile Pro Leu His Ala Ala Ala Ser Cys Gly Tyr Leu Asp Ile Ala 
             100                105                110
Glu Phe Leu Ile Gly Gln Gly Ala His Val Gly Ala Val Asn Ser Glu 
         115                120                125
Gly Asp Thr Pro Leu Asp Ile Ala Glu Glu Glu Ala Met Glu Glu Leu 
     130                135                140
Leu Gln Asn Glu Val Asn Arg Gln Gly Val Asp Ile Glu Ala Ala Arg 
 145                150                155                160
Lys Glu Glu Glu Arg Ile Met Leu Arg Asp Ala Arg Gln Trp Leu Asn 
                 165                170                175
Ser Gly His Ile Ser Asp Val Arg His Ala Lys Ser Gly Gly Thr Ala 
             180                185                190
Leu His Val Ala Ala Ala Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu 
         195                200                205
Ile Gln Ala Gly Tyr Asp Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr 
     210                215                220
Pro Leu His Ala Ala Ala His Trp Gly Lys Glu Glu Ala Cys Arg Ile 
 225                230                235                240
Leu Val Asp Asn Leu Cys Asp Met Glu Thr Val Asn Lys Val Gly Gln 
                 245                250                255
Thr Ala Phe Asp Val Ala Asp Glu Asp Ile Leu Gly Tyr Leu Glu Glu 
             260                265                270
Leu Gln Lys Lys Gln Asn Leu Leu His Ser Glu Lys Arg Asp Lys Lys 
         275                280                285
Ser Pro Leu Ile Glu Ser Thr Ala Asn Met Glu Asn Asn Gln Pro Gln 
     290                295                300
Lys Asn Phe Lys Asn Lys Glu Thr Leu Ile Ile Glu Pro Glu Lys Asn 
 305                310                315                320
Ala Ser Arg Ile Glu Ser Leu Glu Gln Glu Lys Ala Asp Glu Glu Glu 
                 325                330                335
Glu Gly Lys Lys Asp Glu Ser Ser Cys Ser Ser Glu Glu Asp Glu Glu 
             340                345                350
Asp Asp Ser Glu Ser Glu Ala Glu Thr Asp Lys Thr Lys Pro Met Ala 
         355                360                365
Ser Val Thr Asn Ala His Thr Ala Ser Thr Gln Ala Ala Pro Ala Ala 
     370                375                380
Val Thr Thr Pro Thr Leu Ser Ser Asn Gln Gly Thr Pro Thr Ser Pro 
 385                390                395                400
Val Lys Lys Phe Pro Thr Ser Thr Thr Lys Ile Ser Pro Glu Glu Glu 
                 405                410                415
Glu Arg Lys Asp Glu Ser Pro Ala Ser Trp Arg Leu Gly Leu Arg Lys 
             420                425                430
Thr Gly Ser Tyr Gly Ala Leu Ala Glu Ile Thr Ala Ser Lys Glu Ala 
         435                440                445
Gln Lys Glu Lys Asp Thr Ala Gly Val Ile Arg Ser Ala Ser Ser Pro 
     450                455                460
Arg Leu Ser Ser Ser Leu Asp Asn Lys Glu Lys Glu Lys Asp Asn Lys 
 465                470                475                480
Gly Thr Arg Leu Ala Tyr Val Ala Pro Thr Ile Pro Arg Arg Leu Gly 
                 485                490                495
Ser Thr Ser Asp Ile Glu Glu Lys Glu Asn Arg Glu Ser Ser Asn Leu 
             500                505                510
Arg Thr Ser Ser Ser Tyr Thr Arg Arg Lys Trp Glu Asp Asp Leu Lys 
         515                520                525
Lys Asn Ser Ser Ile Asn Glu Gly Ser Thr Tyr His Arg Ser Cys Ser 
     530                535                540
Phe Gly Arg Arg Gln Asp Asp Leu Ile Ser Cys Ser Val Pro Ser Thr 
 545                550                555                560
Thr Ser Thr Pro Thr Val Thr Ser Pro Ala Gly Leu Gln Lys Ser Phe 
                 565                570                575
Leu Ser Ser Thr Ser Thr Thr Ala Lys Thr Pro Pro Gly Ser Ser Pro 
             580                585                590
Ala Gly Thr Gln Ser Arg Ser Tyr Leu Thr Pro Val Arg Asp Glu Glu 
         595                600                605
Ser Glu Ser His Arg Lys Ala Arg Ser Arg Gln Ala Arg Gln Ser Arg 
     610                615                620
Arg Ser Thr Gln Gly Val Thr Leu Thr Asp Leu Gln Glu Ala Glu Lys 
 625                630                635                640
Thr Ile Gly Arg Ser Arg Ser Thr Arg Thr Arg Glu Gln Glu Asn Glu 
                 645                650                655
Glu Lys 
             660



<210> 8608
<211> 4616
<212> DNA
<213> Homo sapiens
<308> XM_006578
<400> 8608

atgaagatg  cggacgcga  gcagaagcg  aacgagcag  tgaaacgct  gatcggctc  60
gagacggac  tcgagcctc  ggtggtgaa  cgccagaag  ccaaggtga  gttcgacga  120
ggcgccgtc  tcctggctg  ttgctccag  ggcgacacg  acgaggtcc  caagctgct  180
caccgcggc  ccgacatca  ttacgccaa  gtggacgga  tcactgccc  gcaccaggc  240
tgcattgat  acaatgttg  tatggtgaa  tttctggta  aaaatggag  aaatattaa  300
caacctgat  atgaaggct  gataccact  catgcagca  cttcctgtg  atatcttga  360
attgcagag  ttttgattg  tcaaggagc  catgtaggg  ctgtcaaca  tgaaggaga  420
acaccttta  atattgcgg  ggaggaggc  atggaagag  tacttcaaa  tgaagttaa  480
cggcaaggg  ttgatatag  agcagctcg  aaggaagaa  aacggatca  gcttagaga  540
gccaggcag  ggctaaata  tggtcatat  aatgatgtc  ggcatgcaa  atctggagg  600
acagcactt  acgttgcag  tgctaaagg  tatacggaa  ttttaaaac  tttaataca  660
gcaggctat  atgttaata  taaagacta  gatggctgg  cacctcttc  tgctgcagc  720
cattggggt  aagaagaag  atgtcgaat  ttagtggac  atctgtgtg  tatggagat  780
gtcaacaaa  tgggccaaa  agcctttga  gtagcagat  aagacattt  aggatattt  840
gaagagttg  aaaagaaac  aaatctgct  catagtgaa  aacgggaca  gaaatctcc  900
ctaattgaa  caacagcaa  tatggacaa  aatcagtca  agaagacct  taaaaacaa  960
gagacgttg  ttattgaac  agagaaaaa  gcatcccgt  ttgaatctc  ggaacaaga  1020
aaggttgat  aagaagaag  aggaaagaa  gatgagtct  gctgctcta  tgaagaaga  1080
gaggaagat  actcggaat  agaagctga  acagataag  caaaacccc  ggcttctgt  1140
actaatgcc  acacttcta  tacacaagc  gctcctgta  ctgttacaa  acctactgt  1200
tcatcaggt  aagcaacac  tacatcacc  attaaaaag  ttccaacca  agctacaaa  1260
atttctccc  aagaagaag  gagaaaaga  gagtctcct  caacttgga  gttaggact  1320
agaaagacg  gcagctatg  tgcacttgc  gaaatcaca  catctaaag  gggtcagaa  1380
gaaaaagat  ctgcaggtg  tacacgttc  gcttcaagt  ccagacttt  ctcctcttt  1440
gataataaa  aaaaggaga  agatagtaa  ggaactagg  ttgcatatg  tgcacctac  1500
ataccaaga  gactagcca  tacatctga  attgaagag  aagaaaaca  agattcttc  1560
agtttgcga  caagtagtt  atatacaag  agaaaatgg  aagatgatc  taaaaaaaa  1620
agctcagtt  atgaaggat  aacgtatca  aaaagttgc  cctttggta  aagacaaga  1680
gatttgatt  gttctagtg  tccaagcac  acatcaaca  caacagtta  ctctgcagc  1740
gggcttcag  aaagcctgc  ttccagcac  agcactact  caaagatta  aacgggttc  1800
tcctcagca  gcacacaaa  cagtacctc  aatcgtttg  gggctgagg  tagtactga  1860
aaagaaaag  acagtgttc  tacggcagt  accattcct  ttgctccaa  tgttgtaaa  1920
gctgcagct  ctaccacaa  cctgactac  actactgct  gcactgtct  ctccacaac  1980
gaggtcagg  agagacgca  atcatacct  actcctgtt  gggatgaag  gtctgaatc  2040
caaagaaaa  caagatcta  acaagcaag  caatctaga  gatcaacac  gggagtgac  2100
ttaactgat  ttcaagaag  tgagaaaac  ataggaaga  gtcgttcta  ccgaaccag  2160
gaacaagaa  atgaagaaa  agaaaaaga  gaaaaagag  aacaagata  agagaaaca  2220
gaagaaaag  aggagtcag  aacatctag  gaagatgaa  ataaacaaa  gtactccag  2280
acgtatgat  agacttacc  gcgttatag  ccagtatca  cttcaagtt  aaccactcc  2340
tcctcttca  tttctacta  gagcagttc  ctgtatgct  caagtcaac  aaacaggcc  2400
aatagtctt  taggcataa  ttctgctta  tccagagga  taacaaaag  aaatgaaag  2460
gagggagaa  aaagagaag  ggagaaaga  ggagaagat  aatcacaac  taaatcaat  2520
agagaacga  gacgaccaa  agagaaaag  agatctaca  gagtttcat  ttggacaca  2580
gatagtgat  aaaatgaac  agaacaaca  tcagacaca  aagagggat  caataagaa  2640
gaaactcag  cggattcca  ttctagata  gaaaccagt  ctacatcag  tggtgatcg  2700
tatgattcc  tgctgggtc  ctctggatc  tacagttac  tagaagaaa  aaaacctta  2760
agcagcagg  tagaaaagg  tgactcaac  gactttaaa  agctttatg  acaaattct  2820
gctgaaaat  aaaagctga  ggcacagct  catgataca  atatggaac  aacagatct  2880
aaattacag  tggaaaagg  cacccagag  caagaaaga  ttgctgata  atcactgtt  2940
gaaatggaa  aaagggaac  aagagctct  gaaagaaga  tatctgaaa  ggaagaaga  3000
ctcaaaatg  taccagacc  aaaagcaga  aaccagagg  taaaggatg  aaatggggc  3060
ttgatcaga  ttataagca  actttccaa  taaaaaaaa  aaaagcagc  agtaatgga  3120
ttgcacata  tagtaaccc  gtggaccat  attggcagt  actggaagt  tgggaagaa  3180
ccttggaga  tgtcatttt  ggatatcct  ccaaatgcc  tcttatcta  aatttttgt  3240
tcattttgt  taattttct  gggtgtttt  gttgttgtt  gtttgtttt  tgttttttt  3300
ttttaatca  gaccattgt  tcatgttaa  gcagctgct  agaagattt  tttttaatg  3360
ctgagaaaa  ttgtttaca  ctccagcat  taaggaaag  gttcaaggc  agatatgcc  3420
cagatattt  accagtaag  cttagttgt  cataaatac  tttgtgtca  caaaaactt  3480
cagctctca  agaagacag  tactcaaca  tttttgatg  gccacagtt  cgagttttt  3540
gatatttaa  ttttttggc  tttcatcta  gtttgggtt  gtatttttt  cttctaaac  3600
cttcatgtg  cagagtctt  tatgttttc  cagcttttt  attacagaa  agaacactt  3660
ctcttctgt  attattgtc  tgtattagg  taatgctgt  ttgtctccc  cctggaact  3720
aattgcttg  tggaacata  gctttcact  tttgtgcaa  atgcattta  ttcttatat  3780
aatgcttta  agtcatttg  ggttagatc  tttaattcc  attttctgc  tcattggtc  3840
ctttttttt  attgtagta  aagatgtta  attctgtaa  cttcacatt  attttagca  3900
gtactgagt  atgctgtat  tacaaataa  tgtattgtt  tgattttta  accaccaca  3960
ggcatgctt  actatttct  atttcaaat  tctgctaat  cagagtagg  tactccatg  4020
tagtgttaa  aaacaaaat  tgctaacaa  gtgatataa  gactttaaa  gttacacat  4080
atgtggagc  ctatcttta  aaaagtttc  tactgtaaa  tgcttttat  ttcagtttt  4140
acttgatag  actcaacca  aattaaagt  gcataagat  attgcttta  atttcacat  4200
cctatattt  tctgagtgc  gtctaaaac  gttgtgcta  ccaaagtaa  gctatgaaa  4260
catttgcag  attaacccg  gagttaatg  taaatgcac  gttattgcc  tgtgaagag  4320
catcgactt  gataccacc  tcatgttca  accatttta  acatttcag  ggccttttt  4380
tttttttaa  gaaaaaaaa  cgcaaaacc  agtacatag  gacgatggc  tttatttgg  4440
caaatagct  ttatatttt  attaaacca  gcaaaaaat  ctacatctt  ctggcacat  4500
actgtctcc  taaccactg  acagttcag  catttgaat  aattgtaca  tgtaaagct  4560
atagtagct  attgtatta  tgattgtat  gtatactat  ttaaatgtg  atttgt  4616



<210> 8609
<211> 1030
<212> PRT
<213> Homo sapiens
<308> XP_006578
<400> 8609

Met Lys Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg 
  1               5                  10                  15
Trp Ile Gly Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Gln 
             20                  25                  30
Lys Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys 
         35                  40                  45
Ser Ser Gly Asp Thr Asp Glu Val Leu Lys Leu Leu His Arg Gly Ala 
     50                  55                  60
Asp Ile Asn Tyr Ala Asn Val Asp Gly Leu Thr Ala Leu His Gln Ala 
 65                  70                  75                  80
Cys Ile Asp Asp Asn Val Asp Met Val Lys Phe Leu Val Glu Asn Gly 
                 85                  90                  95
Ala Asn Ile Asn Gln Pro Asp Asn Glu Gly Trp Ile Pro Leu His Ala 
             100                105                110
Ala Ala Ser Cys Gly Tyr Leu Asp Ile Ala Glu Phe Leu Ile Gly Gln 
         115                120                125
Gly Ala His Val Gly Ala Val Asn Ser Glu Gly Asp Thr Pro Leu Asp 
     130                135                140
Ile Ala Glu Glu Glu Ala Met Glu Glu Leu Leu Gln Asn Glu Val Asn 
 145                150                155                160
Arg Gln Gly Val Asp Ile Glu Ala Ala Arg Lys Glu Glu Glu Arg Ile 
                 165                170                175
Met Leu Arg Asp Ala Arg Gln Trp Leu Asn Ser Gly His Ile Asn Asp 
             180                185                190
Val Arg His Ala Lys Ser Gly Gly Thr Ala Leu His Val Ala Ala Ala 
         195                200                205
Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu Ile Gln Ala Gly Tyr Asp 
     210                215                220
Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr Pro Leu His Ala Ala Ala 
 225                230                235                240
His Trp Gly Lys Glu Glu Ala Cys Arg Ile Leu Val Asp Asn Leu Cys 
                 245                250                255
Asp Met Glu Met Val Asn Lys Val Gly Gln Thr Ala Phe Asp Val Ala 
             260                265                270
Asp Glu Asp Ile Leu Gly Tyr Leu Glu Glu Leu Gln Lys Lys Gln Asn 
         275                280                285
Leu Leu His Ser Glu Lys Arg Asp Lys Lys Ser Pro Leu Ile Glu Ser 
     290                295                300
Thr Ala Asn Met Asp Asn Asn Gln Ser Gln Lys Thr Phe Lys Asn Lys 
 305                310                315                320
Glu Thr Leu Ile Ile Glu Pro Glu Lys Asn Ala Ser Arg Ile Glu Ser 
                 325                330                335
Leu Glu Gln Glu Lys Val Asp Glu Glu Glu Glu Gly Lys Lys Asp Glu 
             340                345                350
Ser Ser Cys Ser Ser Glu Glu Asp Glu Glu Asp Asp Ser Glu Ser Glu 
         355                360                365
Ala Glu Thr Asp Lys Thr Lys Pro Leu Ala Ser Val Thr Asn Ala Asn 
     370                375                380
Thr Ser Ser Thr Gln Ala Ala Pro Val Ala Val Thr Thr Pro Thr Val 
 385                390                395                400
Ser Ser Gly Gln Ala Thr Pro Thr Ser Pro Ile Lys Lys Phe Pro Thr 
                 405                410                415
Thr Ala Thr Lys Ile Ser Pro Lys Glu Glu Glu Arg Lys Asp Glu Ser 
             420                425                430
Pro Ala Thr Trp Arg Leu Gly Leu Arg Lys Thr Gly Ser Tyr Gly Ala 
         435                440                445
Leu Ala Glu Ile Thr Ala Ser Lys Glu Gly Gln Lys Glu Lys Asp Thr 
     450                455                460
Ala Gly Val Thr Arg Ser Ala Ser Ser Pro Arg Leu Ser Ser Ser Leu 
 465                470                475                480
Asp Asn Lys Glu Lys Glu Lys Asp Ser Lys Gly Thr Arg Leu Ala Tyr 
                 485                490                495
Val Ala Pro Thr Ile Pro Arg Arg Leu Ala Ser Thr Ser Asp Ile Glu 
             500                505                510
Glu Lys Glu Asn Arg Asp Ser Ser Ser Leu Arg Thr Ser Ser Ser Tyr 
         515                520                525
Thr Arg Arg Lys Trp Glu Asp Asp Leu Lys Lys Asn Ser Ser Val Asn 
     530                535                540
Glu Gly Ser Thr Tyr His Lys Ser Cys Ser Phe Gly Arg Arg Gln Asp 
 545                550                555                560
Asp Leu Ile Ser Ser Ser Val Pro Ser Thr Thr Ser Thr Pro Thr Val 
                 565                570                575
Thr Ser Ala Ala Gly Leu Gln Lys Ser Leu Leu Ser Ser Thr Ser Thr 
             580                585                590
Thr Thr Lys Ile Thr Thr Gly Ser Ser Ser Ala Gly Thr Gln Ser Ser 
         595                600                605
Thr Ser Asn Arg Leu Trp Ala Glu Asp Ser Thr Glu Lys Glu Lys Asp 
     610                615                620
Ser Val Pro Thr Ala Val Thr Ile Pro Val Ala Pro Thr Val Val Asn 
 625                630                635                640
Ala Ala Ala Ser Thr Thr Thr Leu Thr Thr Thr Thr Ala Gly Thr Val 
                 645                650                655
Ser Ser Thr Thr Glu Val Arg Glu Arg Arg Arg Ser Tyr Leu Thr Pro 
             660                665                670
Val Arg Asp Glu Glu Ser Glu Ser Gln Arg Lys Ala Arg Ser Arg Gln 
         675                680                685
Ala Arg Gln Ser Arg Arg Ser Thr Gln Gly Val Thr Leu Thr Asp Leu 
     690                695                700
Gln Glu Ala Glu Lys Thr Ile Gly Arg Ser Arg Ser Thr Arg Thr Arg 
 705                710                715                720
Glu Gln Glu Asn Glu Glu Lys Glu Lys Glu Glu Lys Glu Lys Gln Asp 
                 725                730                735
Lys Glu Lys Gln Glu Glu Lys Lys Glu Ser Glu Thr Ser Arg Glu Asp 
             740                745                750
Glu Tyr Lys Gln Lys Tyr Ser Arg Thr Tyr Asp Glu Thr Tyr Gln Arg 
         755                760                765
Tyr Arg Pro Val Ser Thr Ser Ser Ser Thr Thr Pro Ser Ser Ser Leu 
     770                775                780
Ser Thr Met Ser Ser Ser Leu Tyr Ala Ser Ser Gln Leu Asn Arg Pro 
 785                790                795                800
Asn Ser Leu Val Gly Ile Thr Ser Ala Tyr Ser Arg Gly Ile Thr Lys 
                 805                810                815
Glu Asn Glu Arg Glu Gly Glu Lys Arg Glu Glu Glu Lys Glu Gly Glu 
             820                825                830
Asp Lys Ser Gln Pro Lys Ser Ile Arg Glu Arg Arg Arg Pro Arg Glu 
         835                840                845
Lys Arg Arg Ser Thr Gly Val Ser Phe Trp Thr Gln Asp Ser Asp Glu 
     850                855                860
Asn Glu Gln Glu Gln Gln Ser Asp Thr Glu Glu Gly Ser Asn Lys Lys 
 865                870                875                880
Glu Thr Gln Thr Asp Ser Ile Ser Arg Tyr Glu Thr Ser Ser Thr Ser 
                 885                890                895
Ala Gly Asp Arg Tyr Asp Ser Leu Leu Gly Arg Ser Gly Ser Tyr Ser 
             900                905                910
Tyr Leu Glu Glu Arg Lys Pro Tyr Ser Ser Arg Leu Glu Lys Asp Asp 
         915                920                925
Ser Thr Asp Phe Lys Lys Leu Tyr Glu Gln Ile Leu Ala Glu Asn Glu 
     930                935                940
Lys Leu Lys Ala Gln Leu His Asp Thr Asn Met Glu Leu Thr Asp Leu 
 945                950                955                960
Lys Leu Gln Leu Glu Lys Ala Thr Gln Arg Gln Glu Arg Phe Ala Asp 
                 965                970                975
Arg Ser Leu Leu Glu Met Glu Lys Arg Glu Arg Arg Ala Leu Glu Arg 
             980                985                990
Arg Ile Ser Glu Met Glu Glu Glu Leu Lys Met Leu Pro Asp Leu Lys 
         995                1000                1005
Ala Asp Asn Gln Arg Leu Lys Asp Glu Asn Gly Ala Leu Ile Arg Val 
     1010                1015                1020
Ile Ser Lys Leu Ser Lys 
 1025                1030



<210> 8610
<211> 1975
<212> DNA
<213> Rattus norvegicus
<308> U50185
<400> 8610

cgcgagcag  tgaagcgct  gatcggctc  gagacggac  tcgagcctc  cgtggtgaa  60
cgccagaag  ccaaggtga  gttcgacga  ggcgccgtc  tcctcgccg  ctgctccag  120
ggcgacacg  acgaggtcc  caagctgct  caccgcggc  ccgacatca  ttacgccaa  180
gtggacgga  tcaccgccc  gcaccaggc  tgcattgat  acaatgttg  tatggtgaa  240
tttctggta  aaaatggag  aaatatcaa  caacctgac  atgaaggct  gattccact  300
catgcagcc  cttcctgtg  atatctgga  attgcagaa  ttttgattg  tcaaggagc  360
catgtagga  ctgtcaaca  tgaaggtga  acaccttta  atattgcag  ggaggaagc  420
atggaagag  tacttcaaa  tgaggttaa  cggcaaggt  ttgatatag  agcagctcg  480
aaagaagag  aacgcataa  gcttagaga  gcgaggcag  ggttgaaca  tggtcacat  540
agtgacgtc  ggcatgcaa  gtccggagg  acagcactc  acgtggcag  ggccaaagg  600
tatacagaa  ttttaaaac  tttaataca  gcaggctat  atgttaata  taaagatta  660
gatggctgg  cacctcttc  tgctgcagc  cactggggt  aagaagaag  atgtcggat  720
ttagtggac  atctgtgtg  tatggagac  gtcaacaaa  tgggccaaa  agcctttga  780
gtagcagat  aagacattt  gggatatct  gaggagttg  aaaaaaaac  aaatctgct  840
catagtgaa  agcgggata  gaaatctcc  ctgattgaa  caacagcaa  tatggaaaa  900
aatcaacca  agaagaatt  taaaaacaa  gaaacgttg  ttattgagc  agagaaaaa  960
gcatctcga  tcgagtctc  ggagcaaga  aaggctgat  aggaggagg  aggcaagaa  1020
gatgagtcc  gctgctcca  tgaggagga  gaggaggat  actccgagt  cgaagcgga  1080
acagataag  caaaaccca  ggcttctgt  actaatgct  acactgcca  cactcaggc  1140
gctcctgcc  ctgtgacaa  acctactct  tcttccaac  aggggaccc  tacatcacc  1200
gttaaaaag  ttcctacat  aactacaaa  atttctccc  aagaagaag  aagaaaaga  1260
gaatctcct  catcctgga  gttaggact  agaaagact  gcagttatg  tgccctggc  1320
gagatcact  catctaaag  agctcagaa  gagaaagac  ctgcaggcg  gatacgttc  1380
gcttcgagt  ccagactct  gtcctcttt  gataataaa  aaaaggaga  agacaataa  1440
ggaacaaga  ttgcatatg  cgcccctac  atcccaagg  gactaggca  tacgtctga  1500
attgaagag  aggaaaaca  agagtcttc  aatttgcga  caagtagtt  ttacacaag  1560
agaaaatgg  aagatgatc  taaaaaaaa  agttcaatc  atgaaggat  tacttacca  1620
agaagttgc  cctttggta  aagacaaga  gatttgatt  gttgtagtg  tccaagcac  1680
acatcaaca  caacagtta  ctctccagc  gggcttcag  aaagcttcc  ttccagcac  1740
agcactact  caaagactc  cccgggttc  tccccagca  gcacacaga  caggtcata  1800
ctcactcct  ttagggatg  agagtctga  tcccacagg  aagcaagat  tagacaagc  1860
agacagtct  gacggtcaa  acagggggt  acactgact  acctccagg  agccgaaaa  1920
acaatagga  gaagccgtt  tacgagaac  agagaacaa  aaaacgaag  aaaag  1975



<210> 8611
<211> 658
<212> PRT
<213> Rattus norvegicus
<308> AAA92961
<400> 8611

Arg Glu Gln Leu Lys Arg Trp Ile Gly Ser Glu Thr Asp Leu Glu Pro 
  1               5                  10                  15
Pro Val Val Lys Arg Gln Lys Thr Lys Val Lys Phe Asp Asp Gly Ala 
             20                  25                  30
Val Phe Leu Ala Ala Cys Ser Ser Gly Asp Thr Asp Glu Val Leu Lys 
         35                  40                  45
Leu Leu His Arg Gly Ala Asp Ile Asn Tyr Ala Asn Val Asp Gly Leu 
     50                  55                  60
Thr Ala Leu His Gln Ala Cys Ile Asp Asp Asn Val Asp Met Val Lys 
 65                  70                  75                  80
Phe Leu Val Glu Asn Gly Ala Asn Ile Asn Gln Pro Asp Asn Glu Gly 
                 85                  90                  95
Trp Ile Pro Leu His Ala Ala Ala Ser Cys Gly Tyr Leu Asp Ile Ala 
             100                105                110
Glu Phe Leu Ile Gly Gln Gly Ala His Val Gly Ala Val Asn Ser Glu 
         115                120                125
Gly Asp Thr Pro Leu Asp Ile Ala Glu Glu Glu Ala Met Glu Glu Leu 
     130                135                140
Leu Gln Asn Glu Val Asn Arg Gln Gly Val Asp Ile Glu Ala Ala Arg 
 145                150                155                160
Lys Glu Glu Glu Arg Ile Met Leu Arg Asp Ala Arg Gln Trp Leu Asn 
                 165                170                175
Ser Gly His Ile Ser Asp Val Arg His Ala Lys Ser Gly Gly Thr Ala 
             180                185                190
Leu His Val Ala Ala Ala Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu 
         195                200                205
Ile Gln Ala Gly Tyr Asp Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr 
     210                215                220
Pro Leu His Ala Ala Ala His Trp Gly Lys Glu Glu Ala Cys Arg Ile 
 225                230                235                240
Leu Val Asp Asn Leu Cys Asp Met Glu Thr Val Asn Lys Val Gly Gln 
                 245                250                255
Thr Ala Phe Asp Val Ala Asp Glu Asp Ile Leu Gly Tyr Leu Glu Glu 
             260                265                270
Leu Gln Lys Lys Gln Asn Leu Leu His Ser Glu Lys Arg Asp Lys Lys 
         275                280                285
Ser Pro Leu Ile Glu Ser Thr Ala Asn Met Glu Asn Asn Gln Pro Gln 
     290                295                300
Lys Asn Phe Lys Asn Lys Glu Thr Leu Ile Ile Glu Pro Glu Lys Asn 
 305                310                315                320
Ala Ser Arg Ile Glu Ser Leu Glu Gln Glu Lys Ala Asp Glu Glu Glu 
                 325                330                335
Glu Gly Lys Lys Asp Glu Ser Ser Cys Ser Ser Glu Glu Asp Glu Glu 
             340                345                350
Asp Asp Ser Glu Ser Glu Ala Glu Thr Asp Lys Thr Lys Pro Met Ala 
         355                360                365
Ser Val Thr Asn Ala His Thr Ala Ser Thr Gln Ala Ala Pro Ala Ala 
     370                375                380
Val Thr Thr Pro Thr Leu Ser Ser Asn Gln Gly Thr Pro Thr Ser Pro 
 385                390                395                400
Val Lys Lys Phe Pro Thr Ser Thr Thr Lys Ile Ser Pro Glu Glu Glu 
                 405                410                415
Glu Arg Lys Asp Glu Ser Pro Ala Ser Trp Arg Leu Gly Leu Arg Lys 
             420                425                430
Thr Gly Ser Tyr Gly Ala Leu Ala Glu Ile Thr Ala Ser Lys Glu Ala 
         435                440                445
Gln Lys Glu Lys Asp Thr Ala Gly Val Ile Arg Ser Ala Ser Ser Pro 
     450                455                460
Arg Leu Ser Ser Ser Leu Asp Asn Lys Glu Lys Glu Lys Asp Asn Lys 
 465                470                475                480
Gly Thr Arg Leu Ala Tyr Val Ala Pro Thr Ile Pro Arg Arg Leu Gly 
                 485                490                495
Ser Thr Ser Asp Ile Glu Glu Lys Glu Asn Arg Glu Ser Ser Asn Leu 
             500                505                510
Arg Thr Ser Ser Ser Tyr Thr Arg Arg Lys Trp Glu Asp Asp Leu Lys 
         515                520                525
Lys Asn Ser Ser Ile Asn Glu Gly Ser Thr Tyr His Arg Ser Cys Ser 
     530                535                540
Phe Gly Arg Arg Gln Asp Asp Leu Ile Ser Cys Ser Val Pro Ser Thr 
 545                550                555                560
Thr Ser Thr Pro Thr Val Thr Ser Pro Ala Gly Leu Gln Lys Ser Phe 
                 565                570                575
Leu Ser Ser Thr Ser Thr Thr Ala Lys Thr Pro Pro Gly Ser Ser Pro 
             580                585                590
Ala Gly Thr Gln Ser Arg Ser Tyr Leu Thr Pro Val Arg Asp Glu Glu 
         595                600                605
Ser Glu Ser His Arg Lys Ala Arg Ser Arg Gln Ala Arg Gln Ser Arg 
     610                615                620
Arg Ser Thr Gln Gly Val Thr Leu Thr Asp Leu Gln Glu Ala Glu Lys 
 625                630                635                640
Thr Ile Gly Arg Ser Arg Ser Thr Arg Thr Arg Glu Gln Glu Asn Glu 
                 645                650                655
Glu Lys 
             660



<210> 8612
<211> 6113
<212> DNA
<213> Homo sapiens
<308> XM_028840
<400> 8612

ccccggtgc  ccgtgctag  ccccagcca  ggcgttggg  agggcggtg  ccatggcca  60
tcacgtgga  ctgctgacg  agctgcagc  gctggagaa  gtgcccacg  tggagcggc  120
gcgggctgc  cagaagcgc  gggcccagc  gctgaagaa  tgggcacag  acgagcagg  180
cttgcagca  cgcaagcga  agcatgagc  gaagcgcag  acgggcggc  gccgcaaga  240
agtgtcctt  gaggccagc  tggccctgc  ggaggcctc  ctgaggaac  acgccgagg  300
agtacgcta  ttcctgaag  ataaggtca  ccctgattt  tgcaatgag  acggactca  360
agccctaca  cagtgctgc  tcgacaact  tgaggaaat  gtgaagctg  tcctctccc  420
tggtgccaa  gtgaacgcc  aggacaacg  gctgtggac  cctctccat  ctgcagcca  480
ctgcggcca  atcaacctg  tgaagatcc  cgttcagta  ggggccgac  tgcttgctg  540
caactcgga  gggaacatg  catatgacc  ctgcgagga  gaacccacc  tggatgtca  600
cgagacctg  atggcatac  agggcatca  ccaagagaa  atcaacgag  tgcgggtgg  660
tcctgagca  cagatgatt  cggacatcc  ctgcatgat  gcagcgggc  aggacctgg  720
ctggataga  gcccagggt  ccacactgc  gcacatagc  ggagccaat  gatacctgc  780
ggcagctga  ctcctcctg  accatggag  gcgtgtgga  gtgaaggac  gggatggct  840
ggagcccct  catgcagct  ccttctggg  acagatgca  atggcagag  tattggtgt  900
ccatggagc  agtctcagt  caaggacat  catggatga  atgccaata  acctgtgcg  960
ggaggaaga  ttcaaggtc  tgctgctgg  gctaaaaca  aagcatgat  tgatcatga  1020
gtcacagct  aggcacaag  catccttga  ccggaggac  tccagcgca  gcagccgtg  1080
gaaggtggt  cggcgagcc  gcctgtcgg  caggaccaa  ctgtatagg  aggagtatg  1140
gggagaggc  atcctgtgg  agcggagtg  agctgagga  cagcggacc  ccacctaca  1200
cggggacat  agggagacc  ggacagacc  agagaataa  gaccctaac  ccaggctgg  1260
gaagcccgt  ctactctcc  aatttccta  caagatccc  cgaggtgaa  tggacatgc  1320
tgttgagaa  ggcctccgg  ctccggtca  tgcctacca  tatgcgctg  ccaacgggg  1380
tgtctggaa  gtgcatgag  tgcctgact  cagcatggc  tatggcaac  ctggcgtgg  1440
cgacgccac  ccgccctgg  gcagctaca  ggaacagag  cctcagacg  ttctggagc  1500
gaagcggca  cgggctgca  ccaagctgc  cagccaccc  ttccttagc  cacacctgg  1560
cagcagcat  gccaggacg  gcgagagta  cagtgaagg  aaggccccc  tgatcggag  1620
cagaacttc  ccgtacagc  gcaatggga  ctcggtata  tacacggtc  ccagcggag  1680
tcccccact  ttaaagttc  aggccccca  agaggagat  gaggagaag  tgcatggct  1740
ttgccgtat  tcctagtct  cgtgtgatg  aggagggag  tgcctgggg  ggggctcct  1800
gaatccagg  cagcccaac  gccctggct  gggaggtgt  agggcagct  gggagaggt  1860
ggctctgct  ttcagagga  ctcagaccc  agccctcag  tggctgccc  tagcatccc  1920
tgtcccacg  cccgtggtt  tgcttcctg  tgcatcgtc  gccatctga  acaaggcct  1980
tcgtggcct  ctggttcac  ctgctgtct  atcttggga  ggtgggctt  agatcccag  2040
tctattctt  gtataaagg  ttctccgga  cagtacatg  atgtcacat  aacacacac  2100
cacacacac  tatacacac  cacacaagc  cgatcagtg  gtgtaggaa  gacatacct  2160
ggctcaggg  aagcaaggg  gcttagaat  tgtggggta  tcccaaaag  atggaagtt  2220
agactcaga  tctcattac  actgccaat  tggttttag  aggggaggg  acctgctaa  2280
ctgagaccc  tagtcctgc  cagagttat  ccaaagtct  agccaccag  cacacctga  2340
aggggtgag  agtcctcgc  gtgttcaga  ggagccagg  atctacatg  gtagatgag  2400
tagacacag  cctgctccc  gcagccttg  tgagagcca  acttctgcc  atgccagga  2460
ccagctgtg  gaccatcca  gggtggagg  ggaaaacca  gcaatttcg  tcctggaat  2520
aaccaaatc  tgttttcct  ttggatgga  gtgtcaaag  cagaagggt  tgggagggg  2580
acaaggtca  tatttacca  agtgtatct  attttaaaa  ttcctttag  ctgtaaaac  2640
cctagaggg  gggaggtaa  tgaattcac  tctttttgt  gatcgtatc  aggtcactg  2700
gttttactg  ctggtgctg  gaaaatgaa  ctaagtgag  agcttccat  ggaatgctt  2760
tccagggag  gaggccagt  aatttaaaa  aaacagtcg  tagttaaca  cgacagagc  2820
cagcaccct  gggtctttg  gaatatcca  actgtttca  cccagccca  ctcagccaa  2880
cctccttag  ctgagctgt  agagcaagc  attaggggc  agcctgcct  cacctccca  2940
ccccttcca  ctccatcag  catgtgtgc  gagtcagtg  tcgggatcc  gggcccagc  3000
tttgccttt  tggggatgc  tggtgagac  gatttgcca  tcagccctt  tgagttccc  3060
cctcaccca  gggctccca  cctgcactt  caggagtgg  gatgcccca  gtctgcgaa  3120
ccagggtgc  cgtggtcaa  atcccctcc  gcattcagg  gagccatgg  agggctaga  3180
ttgggtctt  cccagccct  cagtttcat  gtcccagcc  tcctggtgc  ggggaggga  3240
gactgtgaa  ggctgttct  ccctcactg  tgagtctcc  aggaccccc  ttggagatg  3300
ccatggcat  ggcactgcc  acaggctca  ccagaacct  ttggtgtac  cgataagct  3360
caggttatc  cttgctctg  gcgcctttt  tttgtcctt  aactacctc  ttagagctc  3420
gaaggggtc  cctagttcc  gattttaat  tggggaaca  atctgggtt  tttttaacc  3480
tcttctttc  cagtctatg  gaaacttgc  ctgaggggc  cctgggcta  gggcttggg  3540
ctggaagac  atccccgcc  tgtgccaca  ctttggtca  gggatctgc  ctttgtcat  3600
cttagcccc  tactgtggc  cccatagcc  cataaccca  agagggagc  ggacttcag  3660
gagcctgag  gatgctttc  caggagcag  gcagctggc  ggaccagaa  gtagagggc  3720
catgggagt  actgcaccc  tggtggctg  tggaagggg  gaggttctc  gcatcaggc  3780
acctccacc  caatgccag  atagatgta  tctagagta  gggtggagg  ggcccagga  3840
gctgaagac  ggtgcacag  tgcttccca  gaccttgcc  tttggggtg  gctcttcaa  3900
atctcaggc  gtggctgga  caggacagg  tgatctaaa  cacacgtac  attggctgt  3960
aaacagtat  agcccagac  gacgctgaa  tccctcatg  gccaacctt  gctacaagg  4020
agggagttc  gagggaagc  gcgtgctcc  caggagaga  ctgtttagg  tttccgatc  4080
ttttgctca  gggccaaac  ctgaaggca  gtactgccc  acccactga  cgcctgagg  4140
cattccctc  ttttccgca  gcctcctgc  tcctgggct  ttcctctcc  cccagaagg  4200
tgggaatcc  agctgattc  ctgacagga  ccgacttca  acacaggtg  ctctcaggc  4260
ttggctcat  ttttcagcc  gggataaac  atcccttct  ggggcttta  gtccctggg  4320
agctttccc  gtaggtctc  tgggtgttg  gagacaagt  ggagaccaa  ctccaatga  4380
tgagccgcg  tcattcatt  attcactca  gtaatttac  gagtagctg  aacatgcca  4440
cctctacgt  aggttctgc  gataaagga  gaataagac  gagtcagga  aactgttcc  4500
tgtggtttc  gtcccttgg  gaccacagg  atcagcagt  ccattcaag  cacctgagg  4560
aaagtgtct  catcttcgt  cagcgaccc  ttgcttttc  gctcctaga  tccttagag  4620
ctgaattcc  ttagctggg  acagctgtc  tggtcaccc  tggataaca  ttgccacca  4680
gtatagatg  tggatcttg  gttccaggc  gacatcatc  aggtccatc  ggaactttc  4740
gtgatagct  ccttcagcc  gcatctttg  gggactcta  aatagcagc  tgagatcag  4800
gtctagaag  ctgttctgc  atttgctgc  aaatgcatc  caggttttt  aagtcattg  4860
ttcttgctc  tggtggctc  tttattaca  agtcccctc  ccccactaa  ggataatgg  4920
aggaaaagt  gctgcttcc  tcagcatca  agcctttcc  tgggaatct  cctccctcc  4980
tggcagggg  ggattcggg  gctgggagt  accaggcaa  gtcaaccag  tgcctagct  5040
ctgctgaga  ccaggtcct  tggcagctc  tcattagat  aaaggagac  acttccaaa  5100
caggtgctg  atggctcac  atcatatgc  ccaaacaac  gaaagttgg  ggttatcac  5160
agactgtga  tttctggca  gtagcttgg  gaagctgaa  aaactctag  cccagggct  5220
ctaaagact  caggataga  ttctccatc  aatatacag  ataagtaaa  ctgctctgc  5280
ctgtttaat  catttccaa  gggcttaga  aagctaaca  gggtgtgtc  cctgtcctg  5340
cccaccggt  tgctggctt  gtaataaca  aagaccatt  tggttgttg  tgtcagata  5400
cttcccatc  tgagctctc  cacctacct  ctctctctc  tagagcagg  tactggggt  5460
cttttaaga  gggtgctcc  tttaagatg  ccagaaaag  tgtatttaa  tcttgctat  5520
tgtaacttg  ggatggtct  ccctgcccc  gggcacata  gagcaaagg  tccaatggt  5580
agtggatga  tctgcaaaa  tgaccccct  tgccagaag  tatagccct  tccccaaca  5640
gtctctctt  ttggccaga  ggcctgctt  ccatgggca  tgcaagtgc  accgtgcgg  5700
gcctggctc  gcacaccca  gaaaagtct  cagaccccc  gccctccgc  ataattcac  5760
agaccagaa  ccactggtg  acagagaac  cttaaaaaa  tgtatttta  gtgaaaaaa  5820
attaaaact  tgtatactg  atcagcagc  ttgtgtaaa  atggcaatc  agagagtct  5880
atatattta  aactttttt  aaaaaaatc  tcgcagatc  ttgatatcg  actgaggta  5940
cttccacgt  gccccttgc  acgcggcac  ggtgggcct  gggtccaaa  ctgtggctc  6000
gccacatcc  aaagggggc  catgtccct  gagttgctt  cagctgcca  ggcctgtga  6060
agaattcgc  gttaagagt  tttaattaa  attattaaa  tccttttaa  aac  6113



<210> 8613
<211> 567
<212> PRT
<213> Homo sapiens
<308> XP_028840
<400> 8613

Met Ala Ser His Val Asp Leu Leu Thr Glu Leu Gln Leu Leu Glu Lys 
  1               5                  10                  15
Val Pro Thr Leu Glu Arg Leu Arg Ala Ala Gln Lys Arg Arg Ala Gln 
             20                  25                  30
Gln Leu Lys Lys Trp Ala Gln Tyr Glu Gln Asp Leu Gln His Arg Lys 
         35                  40                  45
Arg Lys His Glu Arg Lys Arg Ser Thr Gly Gly Arg Arg Lys Lys Val 
     50                  55                  60
Ser Phe Glu Ala Ser Val Ala Leu Leu Glu Ala Ser Leu Arg Asn Asp 
 65                  70                  75                  80
Ala Glu Glu Val Arg Tyr Phe Leu Lys Asn Lys Val Ser Pro Asp Leu 
                 85                  90                  95
Cys Asn Glu Asp Gly Leu Thr Ala Leu His Gln Cys Cys Ile Asp Asn 
             100                105                110
Phe Glu Glu Ile Val Lys Leu Leu Leu Ser His Gly Ala Asn Val Asn 
         115                120                125
Ala Lys Asp Asn Glu Leu Trp Thr Pro Leu His Ala Ala Ala Thr Cys 
     130                135                140
Gly His Ile Asn Leu Val Lys Ile Leu Val Gln Tyr Gly Ala Asp Leu 
 145                150                155                160
Leu Ala Val Asn Ser Asp Gly Asn Met Pro Tyr Asp Leu Cys Glu Asp 
                 165                170                175
Glu Pro Thr Leu Asp Val Ile Glu Thr Cys Met Ala Tyr Gln Gly Ile 
             180                185                190
Thr Gln Glu Lys Ile Asn Glu Met Arg Val Ala Pro Glu Gln Gln Met 
         195                200                205
Ile Ala Asp Ile His Cys Met Ile Ala Ala Gly Gln Asp Leu Asp Trp 
     210                215                220
Ile Asp Ala Gln Gly Ala Thr Leu Leu His Ile Ala Gly Ala Asn Gly 
 225                230                235                240
Tyr Leu Arg Ala Ala Glu Leu Leu Leu Asp His Gly Val Arg Val Asp 
                 245                250                255
Val Lys Asp Trp Asp Gly Trp Glu Pro Leu His Ala Ala Ala Phe Trp 
             260                265                270
Gly Gln Met Gln Met Ala Glu Leu Leu Val Ser His Gly Ala Ser Leu 
         275                280                285
Ser Ala Arg Thr Ser Met Asp Glu Met Pro Ile Asp Leu Cys Glu Glu 
     290                295                300
Glu Glu Phe Lys Val Leu Leu Leu Glu Leu Lys His Lys His Asp Val 
 305                310                315                320
Ile Met Lys Ser Gln Leu Arg His Lys Ser Ser Leu Ser Arg Arg Thr 
                 325                330                335
Ser Ser Ala Gly Ser Arg Gly Lys Val Val Arg Arg Ala Ser Leu Ser 
             340                345                350
Asp Arg Thr Asn Leu Tyr Arg Lys Glu Tyr Glu Gly Glu Ala Ile Leu 
         355                360                365
Trp Gln Arg Ser Ala Ala Glu Asp Gln Arg Thr Ser Thr Tyr Asn Gly 
     370                375                380
Asp Ile Arg Glu Thr Arg Thr Asp Gln Glu Asn Lys Asp Pro Asn Pro 
 385                390                395                400
Arg Leu Glu Lys Pro Val Leu Leu Ser Glu Phe Pro Thr Lys Ile Pro 
                 405                410                415
Arg Gly Glu Leu Asp Met Pro Val Glu Asn Gly Leu Arg Ala Pro Val 
             420                425                430
Ser Ala Tyr Gln Tyr Ala Leu Ala Asn Gly Asp Val Trp Lys Val His 
         435                440                445
Glu Val Pro Asp Tyr Ser Met Ala Tyr Gly Asn Pro Gly Val Ala Asp 
     450                455                460
Ala Thr Pro Pro Trp Ser Ser Tyr Lys Glu Gln Ser Pro Gln Thr Leu 
 465                470                475                480
Leu Glu Leu Lys Arg Gln Arg Ala Ala Ala Lys Leu Leu Ser His Pro 
                 485                490                495
Phe Leu Ser Thr His Leu Gly Ser Ser Met Ala Arg Thr Gly Glu Ser 
             500                505                510
Ser Ser Glu Gly Lys Ala Pro Leu Ile Gly Gly Arg Thr Ser Pro Tyr 
         515                520                525
Ser Ser Asn Gly Thr Ser Val Tyr Tyr Thr Val Thr Ser Gly Asp Pro 
     530                535                540
Pro Leu Leu Lys Phe Lys Ala Pro Ile Glu Glu Met Glu Glu Lys Val 
 545                550                555                560
His Gly Cys Cys Arg Ile Ser 
                 565



<210> 8614
<211> 1975
<212> DNA
<213> Rattus norvegicus
<308> U50185
<400> 8614

cgcgagcag  tgaagcgct  gatcggctc  gagacggac  tcgagcctc  cgtggtgaa  60
cgccagaag  ccaaggtga  gttcgacga  ggcgccgtc  tcctcgccg  ctgctccag  120
ggcgacacg  acgaggtcc  caagctgct  caccgcggc  ccgacatca  ttacgccaa  180
gtggacgga  tcaccgccc  gcaccaggc  tgcattgat  acaatgttg  tatggtgaa  240
tttctggta  aaaatggag  aaatatcaa  caacctgac  atgaaggct  gattccact  300
catgcagcc  cttcctgtg  atatctgga  attgcagaa  ttttgattg  tcaaggagc  360
catgtagga  ctgtcaaca  tgaaggtga  acaccttta  atattgcag  ggaggaagc  420
atggaagag  tacttcaaa  tgaggttaa  cggcaaggt  ttgatatag  agcagctcg  480
aaagaagag  aacgcataa  gcttagaga  gcgaggcag  ggttgaaca  tggtcacat  540
agtgacgtc  ggcatgcaa  gtccggagg  acagcactc  acgtggcag  ggccaaagg  600
tatacagaa  ttttaaaac  tttaataca  gcaggctat  atgttaata  taaagatta  660
gatggctgg  cacctcttc  tgctgcagc  cactggggt  aagaagaag  atgtcggat  720
ttagtggac  atctgtgtg  tatggagac  gtcaacaaa  tgggccaaa  agcctttga  780
gtagcagat  aagacattt  gggatatct  gaggagttg  aaaaaaaac  aaatctgct  840
catagtgaa  agcgggata  gaaatctcc  ctgattgaa  caacagcaa  tatggaaaa  900
aatcaacca  agaagaatt  taaaaacaa  gaaacgttg  ttattgagc  agagaaaaa  960
gcatctcga  tcgagtctc  ggagcaaga  aaggctgat  aggaggagg  aggcaagaa  1020
gatgagtcc  gctgctcca  tgaggagga  gaggaggat  actccgagt  cgaagcgga  1080
acagataag  caaaaccca  ggcttctgt  actaatgct  acactgcca  cactcaggc  1140
gctcctgcc  ctgtgacaa  acctactct  tcttccaac  aggggaccc  tacatcacc  1200
gttaaaaag  ttcctacat  aactacaaa  atttctccc  aagaagaag  aagaaaaga  1260
gaatctcct  catcctgga  gttaggact  agaaagact  gcagttatg  tgccctggc  1320
gagatcact  catctaaag  agctcagaa  gagaaagac  ctgcaggcg  gatacgttc  1380
gcttcgagt  ccagactct  gtcctcttt  gataataaa  aaaaggaga  agacaataa  1440
ggaacaaga  ttgcatatg  cgcccctac  atcccaagg  gactaggca  tacgtctga  1500
attgaagag  aggaaaaca  agagtcttc  aatttgcga  caagtagtt  ttacacaag  1560
agaaaatgg  aagatgatc  taaaaaaaa  agttcaatc  atgaaggat  tacttacca  1620
agaagttgc  cctttggta  aagacaaga  gatttgatt  gttgtagtg  tccaagcac  1680
acatcaaca  caacagtta  ctctccagc  gggcttcag  aaagcttcc  ttccagcac  1740
agcactact  caaagactc  cccgggttc  tccccagca  gcacacaga  caggtcata  1800
ctcactcct  ttagggatg  agagtctga  tcccacagg  aagcaagat  tagacaagc  1860
agacagtct  gacggtcaa  acagggggt  acactgact  acctccagg  agccgaaaa  1920
acaatagga  gaagccgtt  tacgagaac  agagaacaa  aaaacgaag  aaaag  1975



<210> 8615
<211> 658
<212> PRT
<213> Rattus norvegicus
<308> AAA92961
<400> 8615

Arg Glu Gln Leu Lys Arg Trp Ile Gly Ser Glu Thr Asp Leu Glu Pro 
  1               5                  10                  15
Pro Val Val Lys Arg Gln Lys Thr Lys Val Lys Phe Asp Asp Gly Ala 
             20                  25                  30
Val Phe Leu Ala Ala Cys Ser Ser Gly Asp Thr Asp Glu Val Leu Lys 
         35                  40                  45
Leu Leu His Arg Gly Ala Asp Ile Asn Tyr Ala Asn Val Asp Gly Leu 
     50                  55                  60
Thr Ala Leu His Gln Ala Cys Ile Asp Asp Asn Val Asp Met Val Lys 
 65                  70                  75                  80
Phe Leu Val Glu Asn Gly Ala Asn Ile Asn Gln Pro Asp Asn Glu Gly 
                 85                  90                  95
Trp Ile Pro Leu His Ala Ala Ala Ser Cys Gly Tyr Leu Asp Ile Ala 
             100                105                110
Glu Phe Leu Ile Gly Gln Gly Ala His Val Gly Ala Val Asn Ser Glu 
         115                120                125
Gly Asp Thr Pro Leu Asp Ile Ala Glu Glu Glu Ala Met Glu Glu Leu 
     130                135                140
Leu Gln Asn Glu Val Asn Arg Gln Gly Val Asp Ile Glu Ala Ala Arg 
 145                150                155                160
Lys Glu Glu Glu Arg Ile Met Leu Arg Asp Ala Arg Gln Trp Leu Asn 
                 165                170                175
Ser Gly His Ile Ser Asp Val Arg His Ala Lys Ser Gly Gly Thr Ala 
             180                185                190
Leu His Val Ala Ala Ala Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu 
         195                200                205
Ile Gln Ala Gly Tyr Asp Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr 
     210                215                220
Pro Leu His Ala Ala Ala His Trp Gly Lys Glu Glu Ala Cys Arg Ile 
 225                230                235                240
Leu Val Asp Asn Leu Cys Asp Met Glu Thr Val Asn Lys Val Gly Gln 
                 245                250                255
Thr Ala Phe Asp Val Ala Asp Glu Asp Ile Leu Gly Tyr Leu Glu Glu 
             260                265                270
Leu Gln Lys Lys Gln Asn Leu Leu His Ser Glu Lys Arg Asp Lys Lys 
         275                280                285
Ser Pro Leu Ile Glu Ser Thr Ala Asn Met Glu Asn Asn Gln Pro Gln 
     290                295                300
Lys Asn Phe Lys Asn Lys Glu Thr Leu Ile Ile Glu Pro Glu Lys Asn 
 305                310                315                320
Ala Ser Arg Ile Glu Ser Leu Glu Gln Glu Lys Ala Asp Glu Glu Glu 
                 325                330                335
Glu Gly Lys Lys Asp Glu Ser Ser Cys Ser Ser Glu Glu Asp Glu Glu 
             340                345                350
Asp Asp Ser Glu Ser Glu Ala Glu Thr Asp Lys Thr Lys Pro Met Ala 
         355                360                365
Ser Val Thr Asn Ala His Thr Ala Ser Thr Gln Ala Ala Pro Ala Ala 
     370                375                380
Val Thr Thr Pro Thr Leu Ser Ser Asn Gln Gly Thr Pro Thr Ser Pro 
 385                390                395                400
Val Lys Lys Phe Pro Thr Ser Thr Thr Lys Ile Ser Pro Glu Glu Glu 
                 405                410                415
Glu Arg Lys Asp Glu Ser Pro Ala Ser Trp Arg Leu Gly Leu Arg Lys 
             420                425                430
Thr Gly Ser Tyr Gly Ala Leu Ala Glu Ile Thr Ala Ser Lys Glu Ala 
         435                440                445
Gln Lys Glu Lys Asp Thr Ala Gly Val Ile Arg Ser Ala Ser Ser Pro 
     450                455                460
Arg Leu Ser Ser Ser Leu Asp Asn Lys Glu Lys Glu Lys Asp Asn Lys 
 465                470                475                480
Gly Thr Arg Leu Ala Tyr Val Ala Pro Thr Ile Pro Arg Arg Leu Gly 
                 485                490                495
Ser Thr Ser Asp Ile Glu Glu Lys Glu Asn Arg Glu Ser Ser Asn Leu 
             500                505                510
Arg Thr Ser Ser Ser Tyr Thr Arg Arg Lys Trp Glu Asp Asp Leu Lys 
         515                520                525
Lys Asn Ser Ser Ile Asn Glu Gly Ser Thr Tyr His Arg Ser Cys Ser 
     530                535                540
Phe Gly Arg Arg Gln Asp Asp Leu Ile Ser Cys Ser Val Pro Ser Thr 
 545                550                555                560
Thr Ser Thr Pro Thr Val Thr Ser Pro Ala Gly Leu Gln Lys Ser Phe 
                 565                570                575
Leu Ser Ser Thr Ser Thr Thr Ala Lys Thr Pro Pro Gly Ser Ser Pro 
             580                585                590
Ala Gly Thr Gln Ser Arg Ser Tyr Leu Thr Pro Val Arg Asp Glu Glu 
         595                600                605
Ser Glu Ser His Arg Lys Ala Arg Ser Arg Gln Ala Arg Gln Ser Arg 
     610                615                620
Arg Ser Thr Gln Gly Val Thr Leu Thr Asp Leu Gln Glu Ala Glu Lys 
 625                630                635                640
Thr Ile Gly Arg Ser Arg Ser Thr Arg Thr Arg Glu Gln Glu Asn Glu 
                 645                650                655
Glu Lys 
             660



<210> 8616
<211> 4616
<212> DNA
<213> Homo sapiens
<308> XM_006578
<400> 8616

atgaagatg  cggacgcga  gcagaagcg  aacgagcag  tgaaacgct  gatcggctc  60
gagacggac  tcgagcctc  ggtggtgaa  cgccagaag  ccaaggtga  gttcgacga  120
ggcgccgtc  tcctggctg  ttgctccag  ggcgacacg  acgaggtcc  caagctgct  180
caccgcggc  ccgacatca  ttacgccaa  gtggacgga  tcactgccc  gcaccaggc  240
tgcattgat  acaatgttg  tatggtgaa  tttctggta  aaaatggag  aaatattaa  300
caacctgat  atgaaggct  gataccact  catgcagca  cttcctgtg  atatcttga  360
attgcagag  ttttgattg  tcaaggagc  catgtaggg  ctgtcaaca  tgaaggaga  420
acaccttta  atattgcgg  ggaggaggc  atggaagag  tacttcaaa  tgaagttaa  480
cggcaaggg  ttgatatag  agcagctcg  aaggaagaa  aacggatca  gcttagaga  540
gccaggcag  ggctaaata  tggtcatat  aatgatgtc  ggcatgcaa  atctggagg  600
acagcactt  acgttgcag  tgctaaagg  tatacggaa  ttttaaaac  tttaataca  660
gcaggctat  atgttaata  taaagacta  gatggctgg  cacctcttc  tgctgcagc  720
cattggggt  aagaagaag  atgtcgaat  ttagtggac  atctgtgtg  tatggagat  780
gtcaacaaa  tgggccaaa  agcctttga  gtagcagat  aagacattt  aggatattt  840
gaagagttg  aaaagaaac  aaatctgct  catagtgaa  aacgggaca  gaaatctcc  900
ctaattgaa  caacagcaa  tatggacaa  aatcagtca  agaagacct  taaaaacaa  960
gagacgttg  ttattgaac  agagaaaaa  gcatcccgt  ttgaatctc  ggaacaaga  1020
aaggttgat  aagaagaag  aggaaagaa  gatgagtct  gctgctcta  tgaagaaga  1080
gaggaagat  actcggaat  agaagctga  acagataag  caaaacccc  ggcttctgt  1140
actaatgcc  acacttcta  tacacaagc  gctcctgta  ctgttacaa  acctactgt  1200
tcatcaggt  aagcaacac  tacatcacc  attaaaaag  ttccaacca  agctacaaa  1260
atttctccc  aagaagaag  gagaaaaga  gagtctcct  caacttgga  gttaggact  1320
agaaagacg  gcagctatg  tgcacttgc  gaaatcaca  catctaaag  gggtcagaa  1380
gaaaaagat  ctgcaggtg  tacacgttc  gcttcaagt  ccagacttt  ctcctcttt  1440
gataataaa  aaaaggaga  agatagtaa  ggaactagg  ttgcatatg  tgcacctac  1500
ataccaaga  gactagcca  tacatctga  attgaagag  aagaaaaca  agattcttc  1560
agtttgcga  caagtagtt  atatacaag  agaaaatgg  aagatgatc  taaaaaaaa  1620
agctcagtt  atgaaggat  aacgtatca  aaaagttgc  cctttggta  aagacaaga  1680
gatttgatt  gttctagtg  tccaagcac  acatcaaca  caacagtta  ctctgcagc  1740
gggcttcag  aaagcctgc  ttccagcac  agcactact  caaagatta  aacgggttc  1800
tcctcagca  gcacacaaa  cagtacctc  aatcgtttg  gggctgagg  tagtactga  1860
aaagaaaag  acagtgttc  tacggcagt  accattcct  ttgctccaa  tgttgtaaa  1920
gctgcagct  ctaccacaa  cctgactac  actactgct  gcactgtct  ctccacaac  1980
gaggtcagg  agagacgca  atcatacct  actcctgtt  gggatgaag  gtctgaatc  2040
caaagaaaa  caagatcta  acaagcaag  caatctaga  gatcaacac  gggagtgac  2100
ttaactgat  ttcaagaag  tgagaaaac  ataggaaga  gtcgttcta  ccgaaccag  2160
gaacaagaa  atgaagaaa  agaaaaaga  gaaaaagag  aacaagata  agagaaaca  2220
gaagaaaag  aggagtcag  aacatctag  gaagatgaa  ataaacaaa  gtactccag  2280
acgtatgat  agacttacc  gcgttatag  ccagtatca  cttcaagtt  aaccactcc  2340
tcctcttca  tttctacta  gagcagttc  ctgtatgct  caagtcaac  aaacaggcc  2400
aatagtctt  taggcataa  ttctgctta  tccagagga  taacaaaag  aaatgaaag  2460
gagggagaa  aaagagaag  ggagaaaga  ggagaagat  aatcacaac  taaatcaat  2520
agagaacga  gacgaccaa  agagaaaag  agatctaca  gagtttcat  ttggacaca  2580
gatagtgat  aaaatgaac  agaacaaca  tcagacaca  aagagggat  caataagaa  2640
gaaactcag  cggattcca  ttctagata  gaaaccagt  ctacatcag  tggtgatcg  2700
tatgattcc  tgctgggtc  ctctggatc  tacagttac  tagaagaaa  aaaacctta  2760
agcagcagg  tagaaaagg  tgactcaac  gactttaaa  agctttatg  acaaattct  2820
gctgaaaat  aaaagctga  ggcacagct  catgataca  atatggaac  aacagatct  2880
aaattacag  tggaaaagg  cacccagag  caagaaaga  ttgctgata  atcactgtt  2940
gaaatggaa  aaagggaac  aagagctct  gaaagaaga  tatctgaaa  ggaagaaga  3000
ctcaaaatg  taccagacc  aaaagcaga  aaccagagg  taaaggatg  aaatggggc  3060
ttgatcaga  ttataagca  actttccaa  taaaaaaaa  aaaagcagc  agtaatgga  3120
ttgcacata  tagtaaccc  gtggaccat  attggcagt  actggaagt  tgggaagaa  3180
ccttggaga  tgtcatttt  ggatatcct  ccaaatgcc  tcttatcta  aatttttgt  3240
tcattttgt  taattttct  gggtgtttt  gttgttgtt  gtttgtttt  tgttttttt  3300
ttttaatca  gaccattgt  tcatgttaa  gcagctgct  agaagattt  tttttaatg  3360
ctgagaaaa  ttgtttaca  ctccagcat  taaggaaag  gttcaaggc  agatatgcc  3420
cagatattt  accagtaag  cttagttgt  cataaatac  tttgtgtca  caaaaactt  3480
cagctctca  agaagacag  tactcaaca  tttttgatg  gccacagtt  cgagttttt  3540
gatatttaa  ttttttggc  tttcatcta  gtttgggtt  gtatttttt  cttctaaac  3600
cttcatgtg  cagagtctt  tatgttttc  cagcttttt  attacagaa  agaacactt  3660
ctcttctgt  attattgtc  tgtattagg  taatgctgt  ttgtctccc  cctggaact  3720
aattgcttg  tggaacata  gctttcact  tttgtgcaa  atgcattta  ttcttatat  3780
aatgcttta  agtcatttg  ggttagatc  tttaattcc  attttctgc  tcattggtc  3840
ctttttttt  attgtagta  aagatgtta  attctgtaa  cttcacatt  attttagca  3900
gtactgagt  atgctgtat  tacaaataa  tgtattgtt  tgattttta  accaccaca  3960
ggcatgctt  actatttct  atttcaaat  tctgctaat  cagagtagg  tactccatg  4020
tagtgttaa  aaacaaaat  tgctaacaa  gtgatataa  gactttaaa  gttacacat  4080
atgtggagc  ctatcttta  aaaagtttc  tactgtaaa  tgcttttat  ttcagtttt  4140
acttgatag  actcaacca  aattaaagt  gcataagat  attgcttta  atttcacat  4200
cctatattt  tctgagtgc  gtctaaaac  gttgtgcta  ccaaagtaa  gctatgaaa  4260
catttgcag  attaacccg  gagttaatg  taaatgcac  gttattgcc  tgtgaagag  4320
catcgactt  gataccacc  tcatgttca  accatttta  acatttcag  ggccttttt  4380
tttttttaa  gaaaaaaaa  cgcaaaacc  agtacatag  gacgatggc  tttatttgg  4440
caaatagct  ttatatttt  attaaacca  gcaaaaaat  ctacatctt  ctggcacat  4500
actgtctcc  taaccactg  acagttcag  catttgaat  aattgtaca  tgtaaagct  4560
atagtagct  attgtatta  tgattgtat  gtatactat  ttaaatgtg  atttgt  4616



<210> 8617
<211> 1030
<212> PRT
<213> Homo sapiens
<308> XP_006578
<400> 8617

Met Lys Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg 
  1               5                  10                  15
Trp Ile Gly Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Gln 
             20                  25                  30
Lys Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys 
         35                  40                  45
Ser Ser Gly Asp Thr Asp Glu Val Leu Lys Leu Leu His Arg Gly Ala 
     50                  55                  60
Asp Ile Asn Tyr Ala Asn Val Asp Gly Leu Thr Ala Leu His Gln Ala 
 65                  70                  75                  80
Cys Ile Asp Asp Asn Val Asp Met Val Lys Phe Leu Val Glu Asn Gly 
                 85                  90                  95
Ala Asn Ile Asn Gln Pro Asp Asn Glu Gly Trp Ile Pro Leu His Ala 
             100                105                110
Ala Ala Ser Cys Gly Tyr Leu Asp Ile Ala Glu Phe Leu Ile Gly Gln 
         115                120                125
Gly Ala His Val Gly Ala Val Asn Ser Glu Gly Asp Thr Pro Leu Asp 
     130                135                140
Ile Ala Glu Glu Glu Ala Met Glu Glu Leu Leu Gln Asn Glu Val Asn 
 145                150                155                160
Arg Gln Gly Val Asp Ile Glu Ala Ala Arg Lys Glu Glu Glu Arg Ile 
                 165                170                175
Met Leu Arg Asp Ala Arg Gln Trp Leu Asn Ser Gly His Ile Asn Asp 
             180                185                190
Val Arg His Ala Lys Ser Gly Gly Thr Ala Leu His Val Ala Ala Ala 
         195                200                205
Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu Ile Gln Ala Gly Tyr Asp 
     210                215                220
Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr Pro Leu His Ala Ala Ala 
 225                230                235                240
His Trp Gly Lys Glu Glu Ala Cys Arg Ile Leu Val Asp Asn Leu Cys 
                 245                250                255
Asp Met Glu Met Val Asn Lys Val Gly Gln Thr Ala Phe Asp Val Ala 
             260                265                270
Asp Glu Asp Ile Leu Gly Tyr Leu Glu Glu Leu Gln Lys Lys Gln Asn 
         275                280                285
Leu Leu His Ser Glu Lys Arg Asp Lys Lys Ser Pro Leu Ile Glu Ser 
     290                295                300
Thr Ala Asn Met Asp Asn Asn Gln Ser Gln Lys Thr Phe Lys Asn Lys 
 305                310                315                320
Glu Thr Leu Ile Ile Glu Pro Glu Lys Asn Ala Ser Arg Ile Glu Ser 
                 325                330                335
Leu Glu Gln Glu Lys Val Asp Glu Glu Glu Glu Gly Lys Lys Asp Glu 
             340                345                350
Ser Ser Cys Ser Ser Glu Glu Asp Glu Glu Asp Asp Ser Glu Ser Glu 
         355                360                365
Ala Glu Thr Asp Lys Thr Lys Pro Leu Ala Ser Val Thr Asn Ala Asn 
     370                375                380
Thr Ser Ser Thr Gln Ala Ala Pro Val Ala Val Thr Thr Pro Thr Val 
 385                390                395                400
Ser Ser Gly Gln Ala Thr Pro Thr Ser Pro Ile Lys Lys Phe Pro Thr 
                 405                410                415
Thr Ala Thr Lys Ile Ser Pro Lys Glu Glu Glu Arg Lys Asp Glu Ser 
             420                425                430
Pro Ala Thr Trp Arg Leu Gly Leu Arg Lys Thr Gly Ser Tyr Gly Ala 
         435                440                445
Leu Ala Glu Ile Thr Ala Ser Lys Glu Gly Gln Lys Glu Lys Asp Thr 
     450                455                460
Ala Gly Val Thr Arg Ser Ala Ser Ser Pro Arg Leu Ser Ser Ser Leu 
 465                470                475                480
Asp Asn Lys Glu Lys Glu Lys Asp Ser Lys Gly Thr Arg Leu Ala Tyr 
                 485                490                495
Val Ala Pro Thr Ile Pro Arg Arg Leu Ala Ser Thr Ser Asp Ile Glu 
             500                505                510
Glu Lys Glu Asn Arg Asp Ser Ser Ser Leu Arg Thr Ser Ser Ser Tyr 
         515                520                525
Thr Arg Arg Lys Trp Glu Asp Asp Leu Lys Lys Asn Ser Ser Val Asn 
     530                535                540
Glu Gly Ser Thr Tyr His Lys Ser Cys Ser Phe Gly Arg Arg Gln Asp 
 545                550                555                560
Asp Leu Ile Ser Ser Ser Val Pro Ser Thr Thr Ser Thr Pro Thr Val 
                 565                570                575
Thr Ser Ala Ala Gly Leu Gln Lys Ser Leu Leu Ser Ser Thr Ser Thr 
             580                585                590
Thr Thr Lys Ile Thr Thr Gly Ser Ser Ser Ala Gly Thr Gln Ser Ser 
         595                600                605
Thr Ser Asn Arg Leu Trp Ala Glu Asp Ser Thr Glu Lys Glu Lys Asp 
     610                615                620
Ser Val Pro Thr Ala Val Thr Ile Pro Val Ala Pro Thr Val Val Asn 
 625                630                635                640
Ala Ala Ala Ser Thr Thr Thr Leu Thr Thr Thr Thr Ala Gly Thr Val 
                 645                650                655
Ser Ser Thr Thr Glu Val Arg Glu Arg Arg Arg Ser Tyr Leu Thr Pro 
             660                665                670
Val Arg Asp Glu Glu Ser Glu Ser Gln Arg Lys Ala Arg Ser Arg Gln 
         675                680                685
Ala Arg Gln Ser Arg Arg Ser Thr Gln Gly Val Thr Leu Thr Asp Leu 
     690                695                700
Gln Glu Ala Glu Lys Thr Ile Gly Arg Ser Arg Ser Thr Arg Thr Arg 
 705                710                715                720
Glu Gln Glu Asn Glu Glu Lys Glu Lys Glu Glu Lys Glu Lys Gln Asp 
                 725                730                735
Lys Glu Lys Gln Glu Glu Lys Lys Glu Ser Glu Thr Ser Arg Glu Asp 
             740                745                750
Glu Tyr Lys Gln Lys Tyr Ser Arg Thr Tyr Asp Glu Thr Tyr Gln Arg 
         755                760                765
Tyr Arg Pro Val Ser Thr Ser Ser Ser Thr Thr Pro Ser Ser Ser Leu 
     770                775                780
Ser Thr Met Ser Ser Ser Leu Tyr Ala Ser Ser Gln Leu Asn Arg Pro 
 785                790                795                800
Asn Ser Leu Val Gly Ile Thr Ser Ala Tyr Ser Arg Gly Ile Thr Lys 
                 805                810                815
Glu Asn Glu Arg Glu Gly Glu Lys Arg Glu Glu Glu Lys Glu Gly Glu 
             820                825                830
Asp Lys Ser Gln Pro Lys Ser Ile Arg Glu Arg Arg Arg Pro Arg Glu 
         835                840                845
Lys Arg Arg Ser Thr Gly Val Ser Phe Trp Thr Gln Asp Ser Asp Glu 
     850                855                860
Asn Glu Gln Glu Gln Gln Ser Asp Thr Glu Glu Gly Ser Asn Lys Lys 
 865                870                875                880
Glu Thr Gln Thr Asp Ser Ile Ser Arg Tyr Glu Thr Ser Ser Thr Ser 
                 885                890                895
Ala Gly Asp Arg Tyr Asp Ser Leu Leu Gly Arg Ser Gly Ser Tyr Ser 
             900                905                910
Tyr Leu Glu Glu Arg Lys Pro Tyr Ser Ser Arg Leu Glu Lys Asp Asp 
         915                920                925
Ser Thr Asp Phe Lys Lys Leu Tyr Glu Gln Ile Leu Ala Glu Asn Glu 
     930                935                940
Lys Leu Lys Ala Gln Leu His Asp Thr Asn Met Glu Leu Thr Asp Leu 
 945                950                955                960
Lys Leu Gln Leu Glu Lys Ala Thr Gln Arg Gln Glu Arg Phe Ala Asp 
                 965                970                975
Arg Ser Leu Leu Glu Met Glu Lys Arg Glu Arg Arg Ala Leu Glu Arg 
             980                985                990
Arg Ile Ser Glu Met Glu Glu Glu Leu Lys Met Leu Pro Asp Leu Lys 
         995                1000                1005
Ala Asp Asn Gln Arg Leu Lys Asp Glu Asn Gly Ala Leu Ile Arg Val 
     1010                1015                1020
Ile Ser Lys Leu Ser Lys 
 1025                1030



<210> 8618
<211> 1975
<212> DNA
<213> Rattus norvegicus
<308> U50185
<400> 8618

cgcgagcag  tgaagcgct  gatcggctc  gagacggac  tcgagcctc  cgtggtgaa  60
cgccagaag  ccaaggtga  gttcgacga  ggcgccgtc  tcctcgccg  ctgctccag  120
ggcgacacg  acgaggtcc  caagctgct  caccgcggc  ccgacatca  ttacgccaa  180
gtggacgga  tcaccgccc  gcaccaggc  tgcattgat  acaatgttg  tatggtgaa  240
tttctggta  aaaatggag  aaatatcaa  caacctgac  atgaaggct  gattccact  300
catgcagcc  cttcctgtg  atatctgga  attgcagaa  ttttgattg  tcaaggagc  360
catgtagga  ctgtcaaca  tgaaggtga  acaccttta  atattgcag  ggaggaagc  420
atggaagag  tacttcaaa  tgaggttaa  cggcaaggt  ttgatatag  agcagctcg  480
aaagaagag  aacgcataa  gcttagaga  gcgaggcag  ggttgaaca  tggtcacat  540
agtgacgtc  ggcatgcaa  gtccggagg  acagcactc  acgtggcag  ggccaaagg  600
tatacagaa  ttttaaaac  tttaataca  gcaggctat  atgttaata  taaagatta  660
gatggctgg  cacctcttc  tgctgcagc  cactggggt  aagaagaag  atgtcggat  720
ttagtggac  atctgtgtg  tatggagac  gtcaacaaa  tgggccaaa  agcctttga  780
gtagcagat  aagacattt  gggatatct  gaggagttg  aaaaaaaac  aaatctgct  840
catagtgaa  agcgggata  gaaatctcc  ctgattgaa  caacagcaa  tatggaaaa  900
aatcaacca  agaagaatt  taaaaacaa  gaaacgttg  ttattgagc  agagaaaaa  960
gcatctcga  tcgagtctc  ggagcaaga  aaggctgat  aggaggagg  aggcaagaa  1020
gatgagtcc  gctgctcca  tgaggagga  gaggaggat  actccgagt  cgaagcgga  1080
acagataag  caaaaccca  ggcttctgt  actaatgct  acactgcca  cactcaggc  1140
gctcctgcc  ctgtgacaa  acctactct  tcttccaac  aggggaccc  tacatcacc  1200
gttaaaaag  ttcctacat  aactacaaa  atttctccc  aagaagaag  aagaaaaga  1260
gaatctcct  catcctgga  gttaggact  agaaagact  gcagttatg  tgccctggc  1320
gagatcact  catctaaag  agctcagaa  gagaaagac  ctgcaggcg  gatacgttc  1380
gcttcgagt  ccagactct  gtcctcttt  gataataaa  aaaaggaga  agacaataa  1440
ggaacaaga  ttgcatatg  cgcccctac  atcccaagg  gactaggca  tacgtctga  1500
attgaagag  aggaaaaca  agagtcttc  aatttgcga  caagtagtt  ttacacaag  1560
agaaaatgg  aagatgatc  taaaaaaaa  agttcaatc  atgaaggat  tacttacca  1620
agaagttgc  cctttggta  aagacaaga  gatttgatt  gttgtagtg  tccaagcac  1680
acatcaaca  caacagtta  ctctccagc  gggcttcag  aaagcttcc  ttccagcac  1740
agcactact  caaagactc  cccgggttc  tccccagca  gcacacaga  caggtcata  1800
ctcactcct  ttagggatg  agagtctga  tcccacagg  aagcaagat  tagacaagc  1860
agacagtct  gacggtcaa  acagggggt  acactgact  acctccagg  agccgaaaa  1920
acaatagga  gaagccgtt  tacgagaac  agagaacaa  aaaacgaag  aaaag  1975



<210> 8619
<211> 658
<212> PRT
<213> Rattus norvegicus
<308> AAA92961
<400> 8619

Arg Glu Gln Leu Lys Arg Trp Ile Gly Ser Glu Thr Asp Leu Glu Pro 
  1               5                  10                  15
Pro Val Val Lys Arg Gln Lys Thr Lys Val Lys Phe Asp Asp Gly Ala 
             20                  25                  30
Val Phe Leu Ala Ala Cys Ser Ser Gly Asp Thr Asp Glu Val Leu Lys 
         35                  40                  45
Leu Leu His Arg Gly Ala Asp Ile Asn Tyr Ala Asn Val Asp Gly Leu 
     50                  55                  60
Thr Ala Leu His Gln Ala Cys Ile Asp Asp Asn Val Asp Met Val Lys 
 65                  70                  75                  80
Phe Leu Val Glu Asn Gly Ala Asn Ile Asn Gln Pro Asp Asn Glu Gly 
                 85                  90                  95
Trp Ile Pro Leu His Ala Ala Ala Ser Cys Gly Tyr Leu Asp Ile Ala 
             100                105                110
Glu Phe Leu Ile Gly Gln Gly Ala His Val Gly Ala Val Asn Ser Glu 
         115                120                125
Gly Asp Thr Pro Leu Asp Ile Ala Glu Glu Glu Ala Met Glu Glu Leu 
     130                135                140
Leu Gln Asn Glu Val Asn Arg Gln Gly Val Asp Ile Glu Ala Ala Arg 
 145                150                155                160
Lys Glu Glu Glu Arg Ile Met Leu Arg Asp Ala Arg Gln Trp Leu Asn 
                 165                170                175
Ser Gly His Ile Ser Asp Val Arg His Ala Lys Ser Gly Gly Thr Ala 
             180                185                190
Leu His Val Ala Ala Ala Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu 
         195                200                205
Ile Gln Ala Gly Tyr Asp Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr 
     210                215                220
Pro Leu His Ala Ala Ala His Trp Gly Lys Glu Glu Ala Cys Arg Ile 
 225                230                235                240
Leu Val Asp Asn Leu Cys Asp Met Glu Thr Val Asn Lys Val Gly Gln 
                 245                250                255
Thr Ala Phe Asp Val Ala Asp Glu Asp Ile Leu Gly Tyr Leu Glu Glu 
             260                265                270
Leu Gln Lys Lys Gln Asn Leu Leu His Ser Glu Lys Arg Asp Lys Lys 
         275                280                285
Ser Pro Leu Ile Glu Ser Thr Ala Asn Met Glu Asn Asn Gln Pro Gln 
     290                295                300
Lys Asn Phe Lys Asn Lys Glu Thr Leu Ile Ile Glu Pro Glu Lys Asn 
 305                310                315                320
Ala Ser Arg Ile Glu Ser Leu Glu Gln Glu Lys Ala Asp Glu Glu Glu 
                 325                330                335
Glu Gly Lys Lys Asp Glu Ser Ser Cys Ser Ser Glu Glu Asp Glu Glu 
             340                345                350
Asp Asp Ser Glu Ser Glu Ala Glu Thr Asp Lys Thr Lys Pro Met Ala 
         355                360                365
Ser Val Thr Asn Ala His Thr Ala Ser Thr Gln Ala Ala Pro Ala Ala 
     370                375                380
Val Thr Thr Pro Thr Leu Ser Ser Asn Gln Gly Thr Pro Thr Ser Pro 
 385                390                395                400
Val Lys Lys Phe Pro Thr Ser Thr Thr Lys Ile Ser Pro Glu Glu Glu 
                 405                410                415
Glu Arg Lys Asp Glu Ser Pro Ala Ser Trp Arg Leu Gly Leu Arg Lys 
             420                425                430
Thr Gly Ser Tyr Gly Ala Leu Ala Glu Ile Thr Ala Ser Lys Glu Ala 
         435                440                445
Gln Lys Glu Lys Asp Thr Ala Gly Val Ile Arg Ser Ala Ser Ser Pro 
     450                455                460
Arg Leu Ser Ser Ser Leu Asp Asn Lys Glu Lys Glu Lys Asp Asn Lys 
 465                470                475                480
Gly Thr Arg Leu Ala Tyr Val Ala Pro Thr Ile Pro Arg Arg Leu Gly 
                 485                490                495
Ser Thr Ser Asp Ile Glu Glu Lys Glu Asn Arg Glu Ser Ser Asn Leu 
             500                505                510
Arg Thr Ser Ser Ser Tyr Thr Arg Arg Lys Trp Glu Asp Asp Leu Lys 
         515                520                525
Lys Asn Ser Ser Ile Asn Glu Gly Ser Thr Tyr His Arg Ser Cys Ser 
     530                535                540
Phe Gly Arg Arg Gln Asp Asp Leu Ile Ser Cys Ser Val Pro Ser Thr 
 545                550                555                560
Thr Ser Thr Pro Thr Val Thr Ser Pro Ala Gly Leu Gln Lys Ser Phe 
                 565                570                575
Leu Ser Ser Thr Ser Thr Thr Ala Lys Thr Pro Pro Gly Ser Ser Pro 
             580                585                590
Ala Gly Thr Gln Ser Arg Ser Tyr Leu Thr Pro Val Arg Asp Glu Glu 
         595                600                605
Ser Glu Ser His Arg Lys Ala Arg Ser Arg Gln Ala Arg Gln Ser Arg 
     610                615                620
Arg Ser Thr Gln Gly Val Thr Leu Thr Asp Leu Gln Glu Ala Glu Lys 
 625                630                635                640
Thr Ile Gly Arg Ser Arg Ser Thr Arg Thr Arg Glu Gln Glu Asn Glu 
                 645                650                655
Glu Lys 
             660



<210> 8620
<211> 6113
<212> DNA
<213> Homo sapiens
<308> XM_028840
<400> 8620

ccccggtgc  ccgtgctag  ccccagcca  ggcgttggg  agggcggtg  ccatggcca  60
tcacgtgga  ctgctgacg  agctgcagc  gctggagaa  gtgcccacg  tggagcggc  120
gcgggctgc  cagaagcgc  gggcccagc  gctgaagaa  tgggcacag  acgagcagg  180
cttgcagca  cgcaagcga  agcatgagc  gaagcgcag  acgggcggc  gccgcaaga  240
agtgtcctt  gaggccagc  tggccctgc  ggaggcctc  ctgaggaac  acgccgagg  300
agtacgcta  ttcctgaag  ataaggtca  ccctgattt  tgcaatgag  acggactca  360
agccctaca  cagtgctgc  tcgacaact  tgaggaaat  gtgaagctg  tcctctccc  420
tggtgccaa  gtgaacgcc  aggacaacg  gctgtggac  cctctccat  ctgcagcca  480
ctgcggcca  atcaacctg  tgaagatcc  cgttcagta  ggggccgac  tgcttgctg  540
caactcgga  gggaacatg  catatgacc  ctgcgagga  gaacccacc  tggatgtca  600
cgagacctg  atggcatac  agggcatca  ccaagagaa  atcaacgag  tgcgggtgg  660
tcctgagca  cagatgatt  cggacatcc  ctgcatgat  gcagcgggc  aggacctgg  720
ctggataga  gcccagggt  ccacactgc  gcacatagc  ggagccaat  gatacctgc  780
ggcagctga  ctcctcctg  accatggag  gcgtgtgga  gtgaaggac  gggatggct  840
ggagcccct  catgcagct  ccttctggg  acagatgca  atggcagag  tattggtgt  900
ccatggagc  agtctcagt  caaggacat  catggatga  atgccaata  acctgtgcg  960
ggaggaaga  ttcaaggtc  tgctgctgg  gctaaaaca  aagcatgat  tgatcatga  1020
gtcacagct  aggcacaag  catccttga  ccggaggac  tccagcgca  gcagccgtg  1080
gaaggtggt  cggcgagcc  gcctgtcgg  caggaccaa  ctgtatagg  aggagtatg  1140
gggagaggc  atcctgtgg  agcggagtg  agctgagga  cagcggacc  ccacctaca  1200
cggggacat  agggagacc  ggacagacc  agagaataa  gaccctaac  ccaggctgg  1260
gaagcccgt  ctactctcc  aatttccta  caagatccc  cgaggtgaa  tggacatgc  1320
tgttgagaa  ggcctccgg  ctccggtca  tgcctacca  tatgcgctg  ccaacgggg  1380
tgtctggaa  gtgcatgag  tgcctgact  cagcatggc  tatggcaac  ctggcgtgg  1440
cgacgccac  ccgccctgg  gcagctaca  ggaacagag  cctcagacg  ttctggagc  1500
gaagcggca  cgggctgca  ccaagctgc  cagccaccc  ttccttagc  cacacctgg  1560
cagcagcat  gccaggacg  gcgagagta  cagtgaagg  aaggccccc  tgatcggag  1620
cagaacttc  ccgtacagc  gcaatggga  ctcggtata  tacacggtc  ccagcggag  1680
tcccccact  ttaaagttc  aggccccca  agaggagat  gaggagaag  tgcatggct  1740
ttgccgtat  tcctagtct  cgtgtgatg  aggagggag  tgcctgggg  ggggctcct  1800
gaatccagg  cagcccaac  gccctggct  gggaggtgt  agggcagct  gggagaggt  1860
ggctctgct  ttcagagga  ctcagaccc  agccctcag  tggctgccc  tagcatccc  1920
tgtcccacg  cccgtggtt  tgcttcctg  tgcatcgtc  gccatctga  acaaggcct  1980
tcgtggcct  ctggttcac  ctgctgtct  atcttggga  ggtgggctt  agatcccag  2040
tctattctt  gtataaagg  ttctccgga  cagtacatg  atgtcacat  aacacacac  2100
cacacacac  tatacacac  cacacaagc  cgatcagtg  gtgtaggaa  gacatacct  2160
ggctcaggg  aagcaaggg  gcttagaat  tgtggggta  tcccaaaag  atggaagtt  2220
agactcaga  tctcattac  actgccaat  tggttttag  aggggaggg  acctgctaa  2280
ctgagaccc  tagtcctgc  cagagttat  ccaaagtct  agccaccag  cacacctga  2340
aggggtgag  agtcctcgc  gtgttcaga  ggagccagg  atctacatg  gtagatgag  2400
tagacacag  cctgctccc  gcagccttg  tgagagcca  acttctgcc  atgccagga  2460
ccagctgtg  gaccatcca  gggtggagg  ggaaaacca  gcaatttcg  tcctggaat  2520
aaccaaatc  tgttttcct  ttggatgga  gtgtcaaag  cagaagggt  tgggagggg  2580
acaaggtca  tatttacca  agtgtatct  attttaaaa  ttcctttag  ctgtaaaac  2640
cctagaggg  gggaggtaa  tgaattcac  tctttttgt  gatcgtatc  aggtcactg  2700
gttttactg  ctggtgctg  gaaaatgaa  ctaagtgag  agcttccat  ggaatgctt  2760
tccagggag  gaggccagt  aatttaaaa  aaacagtcg  tagttaaca  cgacagagc  2820
cagcaccct  gggtctttg  gaatatcca  actgtttca  cccagccca  ctcagccaa  2880
cctccttag  ctgagctgt  agagcaagc  attaggggc  agcctgcct  cacctccca  2940
ccccttcca  ctccatcag  catgtgtgc  gagtcagtg  tcgggatcc  gggcccagc  3000
tttgccttt  tggggatgc  tggtgagac  gatttgcca  tcagccctt  tgagttccc  3060
cctcaccca  gggctccca  cctgcactt  caggagtgg  gatgcccca  gtctgcgaa  3120
ccagggtgc  cgtggtcaa  atcccctcc  gcattcagg  gagccatgg  agggctaga  3180
ttgggtctt  cccagccct  cagtttcat  gtcccagcc  tcctggtgc  ggggaggga  3240
gactgtgaa  ggctgttct  ccctcactg  tgagtctcc  aggaccccc  ttggagatg  3300
ccatggcat  ggcactgcc  acaggctca  ccagaacct  ttggtgtac  cgataagct  3360
caggttatc  cttgctctg  gcgcctttt  tttgtcctt  aactacctc  ttagagctc  3420
gaaggggtc  cctagttcc  gattttaat  tggggaaca  atctgggtt  tttttaacc  3480
tcttctttc  cagtctatg  gaaacttgc  ctgaggggc  cctgggcta  gggcttggg  3540
ctggaagac  atccccgcc  tgtgccaca  ctttggtca  gggatctgc  ctttgtcat  3600
cttagcccc  tactgtggc  cccatagcc  cataaccca  agagggagc  ggacttcag  3660
gagcctgag  gatgctttc  caggagcag  gcagctggc  ggaccagaa  gtagagggc  3720
catgggagt  actgcaccc  tggtggctg  tggaagggg  gaggttctc  gcatcaggc  3780
acctccacc  caatgccag  atagatgta  tctagagta  gggtggagg  ggcccagga  3840
gctgaagac  ggtgcacag  tgcttccca  gaccttgcc  tttggggtg  gctcttcaa  3900
atctcaggc  gtggctgga  caggacagg  tgatctaaa  cacacgtac  attggctgt  3960
aaacagtat  agcccagac  gacgctgaa  tccctcatg  gccaacctt  gctacaagg  4020
agggagttc  gagggaagc  gcgtgctcc  caggagaga  ctgtttagg  tttccgatc  4080
ttttgctca  gggccaaac  ctgaaggca  gtactgccc  acccactga  cgcctgagg  4140
cattccctc  ttttccgca  gcctcctgc  tcctgggct  ttcctctcc  cccagaagg  4200
tgggaatcc  agctgattc  ctgacagga  ccgacttca  acacaggtg  ctctcaggc  4260
ttggctcat  ttttcagcc  gggataaac  atcccttct  ggggcttta  gtccctggg  4320
agctttccc  gtaggtctc  tgggtgttg  gagacaagt  ggagaccaa  ctccaatga  4380
tgagccgcg  tcattcatt  attcactca  gtaatttac  gagtagctg  aacatgcca  4440
cctctacgt  aggttctgc  gataaagga  gaataagac  gagtcagga  aactgttcc  4500
tgtggtttc  gtcccttgg  gaccacagg  atcagcagt  ccattcaag  cacctgagg  4560
aaagtgtct  catcttcgt  cagcgaccc  ttgcttttc  gctcctaga  tccttagag  4620
ctgaattcc  ttagctggg  acagctgtc  tggtcaccc  tggataaca  ttgccacca  4680
gtatagatg  tggatcttg  gttccaggc  gacatcatc  aggtccatc  ggaactttc  4740
gtgatagct  ccttcagcc  gcatctttg  gggactcta  aatagcagc  tgagatcag  4800
gtctagaag  ctgttctgc  atttgctgc  aaatgcatc  caggttttt  aagtcattg  4860
ttcttgctc  tggtggctc  tttattaca  agtcccctc  ccccactaa  ggataatgg  4920
aggaaaagt  gctgcttcc  tcagcatca  agcctttcc  tgggaatct  cctccctcc  4980
tggcagggg  ggattcggg  gctgggagt  accaggcaa  gtcaaccag  tgcctagct  5040
ctgctgaga  ccaggtcct  tggcagctc  tcattagat  aaaggagac  acttccaaa  5100
caggtgctg  atggctcac  atcatatgc  ccaaacaac  gaaagttgg  ggttatcac  5160
agactgtga  tttctggca  gtagcttgg  gaagctgaa  aaactctag  cccagggct  5220
ctaaagact  caggataga  ttctccatc  aatatacag  ataagtaaa  ctgctctgc  5280
ctgtttaat  catttccaa  gggcttaga  aagctaaca  gggtgtgtc  cctgtcctg  5340
cccaccggt  tgctggctt  gtaataaca  aagaccatt  tggttgttg  tgtcagata  5400
cttcccatc  tgagctctc  cacctacct  ctctctctc  tagagcagg  tactggggt  5460
cttttaaga  gggtgctcc  tttaagatg  ccagaaaag  tgtatttaa  tcttgctat  5520
tgtaacttg  ggatggtct  ccctgcccc  gggcacata  gagcaaagg  tccaatggt  5580
agtggatga  tctgcaaaa  tgaccccct  tgccagaag  tatagccct  tccccaaca  5640
gtctctctt  ttggccaga  ggcctgctt  ccatgggca  tgcaagtgc  accgtgcgg  5700
gcctggctc  gcacaccca  gaaaagtct  cagaccccc  gccctccgc  ataattcac  5760
agaccagaa  ccactggtg  acagagaac  cttaaaaaa  tgtatttta  gtgaaaaaa  5820
attaaaact  tgtatactg  atcagcagc  ttgtgtaaa  atggcaatc  agagagtct  5880
atatattta  aactttttt  aaaaaaatc  tcgcagatc  ttgatatcg  actgaggta  5940
cttccacgt  gccccttgc  acgcggcac  ggtgggcct  gggtccaaa  ctgtggctc  6000
gccacatcc  aaagggggc  catgtccct  gagttgctt  cagctgcca  ggcctgtga  6060
agaattcgc  gttaagagt  tttaattaa  attattaaa  tccttttaa  aac  6113



<210> 8621
<211> 567
<212> PRT
<213> Homo sapiens
<308> XP_028840
<400> 8621

Met Ala Ser His Val Asp Leu Leu Thr Glu Leu Gln Leu Leu Glu Lys 
  1               5                  10                  15
Val Pro Thr Leu Glu Arg Leu Arg Ala Ala Gln Lys Arg Arg Ala Gln 
             20                  25                  30
Gln Leu Lys Lys Trp Ala Gln Tyr Glu Gln Asp Leu Gln His Arg Lys 
         35                  40                  45
Arg Lys His Glu Arg Lys Arg Ser Thr Gly Gly Arg Arg Lys Lys Val 
     50                  55                  60
Ser Phe Glu Ala Ser Val Ala Leu Leu Glu Ala Ser Leu Arg Asn Asp 
 65                  70                  75                  80
Ala Glu Glu Val Arg Tyr Phe Leu Lys Asn Lys Val Ser Pro Asp Leu 
                 85                  90                  95
Cys Asn Glu Asp Gly Leu Thr Ala Leu His Gln Cys Cys Ile Asp Asn 
             100                105                110
Phe Glu Glu Ile Val Lys Leu Leu Leu Ser His Gly Ala Asn Val Asn 
         115                120                125
Ala Lys Asp Asn Glu Leu Trp Thr Pro Leu His Ala Ala Ala Thr Cys 
     130                135                140
Gly His Ile Asn Leu Val Lys Ile Leu Val Gln Tyr Gly Ala Asp Leu 
 145                150                155                160
Leu Ala Val Asn Ser Asp Gly Asn Met Pro Tyr Asp Leu Cys Glu Asp 
                 165                170                175
Glu Pro Thr Leu Asp Val Ile Glu Thr Cys Met Ala Tyr Gln Gly Ile 
             180                185                190
Thr Gln Glu Lys Ile Asn Glu Met Arg Val Ala Pro Glu Gln Gln Met 
         195                200                205
Ile Ala Asp Ile His Cys Met Ile Ala Ala Gly Gln Asp Leu Asp Trp 
     210                215                220
Ile Asp Ala Gln Gly Ala Thr Leu Leu His Ile Ala Gly Ala Asn Gly 
 225                230                235                240
Tyr Leu Arg Ala Ala Glu Leu Leu Leu Asp His Gly Val Arg Val Asp 
                 245                250                255
Val Lys Asp Trp Asp Gly Trp Glu Pro Leu His Ala Ala Ala Phe Trp 
             260                265                270
Gly Gln Met Gln Met Ala Glu Leu Leu Val Ser His Gly Ala Ser Leu 
         275                280                285
Ser Ala Arg Thr Ser Met Asp Glu Met Pro Ile Asp Leu Cys Glu Glu 
     290                295                300
Glu Glu Phe Lys Val Leu Leu Leu Glu Leu Lys His Lys His Asp Val 
 305                310                315                320
Ile Met Lys Ser Gln Leu Arg His Lys Ser Ser Leu Ser Arg Arg Thr 
                 325                330                335
Ser Ser Ala Gly Ser Arg Gly Lys Val Val Arg Arg Ala Ser Leu Ser 
             340                345                350
Asp Arg Thr Asn Leu Tyr Arg Lys Glu Tyr Glu Gly Glu Ala Ile Leu 
         355                360                365
Trp Gln Arg Ser Ala Ala Glu Asp Gln Arg Thr Ser Thr Tyr Asn Gly 
     370                375                380
Asp Ile Arg Glu Thr Arg Thr Asp Gln Glu Asn Lys Asp Pro Asn Pro 
 385                390                395                400
Arg Leu Glu Lys Pro Val Leu Leu Ser Glu Phe Pro Thr Lys Ile Pro 
                 405                410                415
Arg Gly Glu Leu Asp Met Pro Val Glu Asn Gly Leu Arg Ala Pro Val 
             420                425                430
Ser Ala Tyr Gln Tyr Ala Leu Ala Asn Gly Asp Val Trp Lys Val His 
         435                440                445
Glu Val Pro Asp Tyr Ser Met Ala Tyr Gly Asn Pro Gly Val Ala Asp 
     450                455                460
Ala Thr Pro Pro Trp Ser Ser Tyr Lys Glu Gln Ser Pro Gln Thr Leu 
 465                470                475                480
Leu Glu Leu Lys Arg Gln Arg Ala Ala Ala Lys Leu Leu Ser His Pro 
                 485                490                495
Phe Leu Ser Thr His Leu Gly Ser Ser Met Ala Arg Thr Gly Glu Ser 
             500                505                510
Ser Ser Glu Gly Lys Ala Pro Leu Ile Gly Gly Arg Thr Ser Pro Tyr 
         515                520                525
Ser Ser Asn Gly Thr Ser Val Tyr Tyr Thr Val Thr Ser Gly Asp Pro 
     530                535                540
Pro Leu Leu Lys Phe Lys Ala Pro Ile Glu Glu Met Glu Glu Lys Val 
 545                550                555                560
His Gly Cys Cys Arg Ile Ser 
                 565



<210> 8622
<211> 3046
<212> DNA
<213> Rattus norvegicus
<308> U50353
<400> 8622

ctccatttc  ctgccatat  tccagccag  gggacattc  gaagacctt  tgtctcaag  60
aacaagggc  tgaatgttt  gccaatgtg  ctctggaga  ctgtttagc  ctattggtg  120
ccaggagag  ttgcatgct  ttctttcag  gtatgactt  aaatagata  ttcaatcat  180
tggcagact  cattagaac  tacaggaga  ttaatgtaa  atctcagta  ggtatagtg  240
gcttactct  ctgaatggc  taactagtt  cggcagttg  aactgaggt  ctaggcagg  300
ttactgaga  ctagttttc  aatccttct  tttgtgctc  ttgaacatg  gttctagtc  360
tctccacaa  gccaaagtc  tcatttaca  gccacacat  tcctgtata  tctttcata  420
gtcctgata  cagtgatta  actttagcc  cagagctat  cagcaaagc  acttggagt  480
aatagcaat  gacaaatgg  tgttatcta  tgttggact  gataaataa  aagtcctac  540
tgtaagccc  gctttgttc  cagcttttc  aaattgctt  actgccctt  caccacagg  600
gtttcaggt  tccaataga  attaaccac  aaaaaatta  gacatcaca  gtgaccctt  660
aataggaga  gtctgtcca  gatgtttca  ctgctcctg  attccaagg  ctggaaaga  720
gagcgctgt  tctcttgct  tgctctccc  gcatacgcc  aagtctgta  gtaatgaat  780
taattttca  agtatgggt  tgtccctga  gcctaggtg  aagggactc  ctaaaggca  840
gggtgctct  gaggaggcc  tgtcatcag  ccccttcta  tgttcttct  tctggggct  900
tggtatctg  aatggacag  aattcctgt  aaggggaaa  tcagaaatc  ttcccaaaa  960
acaaatgtc  cccttgtca  tacagtaga  ataataaca  aatctttaa  atgtctgtg  1020
actataaga  atatctctt  ttttcagtt  gctttggct  ctgaattgc  cacgatgtc  1080
atatatttt  ggtattagt  tcttttcaa  tgtatgctt  gctaacttt  acccccatg  1140
tctagcttc  tatgtcacc  tgatgcttg  ttcctcacc  gtgcaaaga  tctaagggc  1200
gcaaagccc  gtggaatcc  acaatcccc  ttggccacc  gctttgttg  cagaacttt  1260
ggtttcatg  aagacatca  tttacagac  cagtctgat  tactctagt  gtttatgct  1320
tacgtctta  gtctaggtc  ttactttag  tgagaaaag  tcaatgtgg  caacaagca  1380
taagtctct  aaccatcag  atcctggtg  cacccctga  tgtcacctt  agaaaacag  1440
ttaagagca  atcttcaga  atttagagt  attggtcct  agacttaat  catgaaagt  1500
ctgtttctt  tctcttttt  acattaaaa  acaaatact  attcaaatt  tagtacata  1560
tccaaatgg  aacaggaaa  catagcagg  tcctcctaa  cctcaccag  ttaaaccaa  1620
gatagccac  aaacattgg  acaaagttt  ttataaggg  tgctgtaag  tcaaaggta  1680
caagaaatt  tgggggaca  atccctttc  ttatcaatg  agacacttt  tacctgcag  1740
gcctatgtc  gattcttct  ttcacatcc  ccaccacat  cacagaaac  cacacacac  1800
cacacacac  cacacacac  gtttctgac  ttttttcat  ccttaggaa  ccacagcca  1860
gaggaccct  actctgctc  ccacccttc  cctgctggc  ctccacacc  aggcagaat  1920
tccccaagg  agcactaag  aagctccag  tgaggagca  gatatttcc  tattctttg  1980
aggggataa  ggcactgct  tccaagatg  aggtgagag  cgttatcat  ctagagaca  2040
ggaggagag  ggagtgggg  atgctctga  tttgggtca  ccgtttaac  ttattactt  2100
tttatgttc  tcatttcac  gcaagagac  aatagatca  tttcttgct  caaagatct  2160
tttggcgga  atcatgggg  ttaatacat  agaagactc  gtgactgtt  ttttctaga  2220
ctaaatgac  agacttgca  tttattttg  ctattacat  gtaaaaatt  gagatgtgt  2280
tgtaagtat  tatgtaatg  caggcacac  tagaatgat  acaaaatta  gacaaaagg  2340
catcggtct  tagttttgt  attactatt  gtatttatt  ctattgatc  tgattgttc  2400
tgctgctgt  actaacaac  aaagcagcg  gcccacttc  cacagcaca  atgttgccc  2460
agattcttc  tccctgctg  ttcaggcac  aagtacttc  tatgatgtc  gtttcccca  2520
ctgtgaagg  aggcgtgac  tgctcttgt  gaacctcaa  ctgtcgttt  ggagaaagg  2580
tctctgggg  atgtcgtct  aatggccgc  tctaccgac  ctgttgctg  gcacaaaga  2640
gaagaagaa  aagaagaag  agaagaaga  gaagaagaa  aagaagaag  agaagaaga  2700
gaagaagaa  aagaagaag  agaagaaga  gaagaagaa  aagaagaag  agaagaaga  2760
gaagaagaa  aagaagaag  agaagaaga  gaagaagaa  aagaatcca  ttgtcatat  2820
acttgaagg  gactgttat  tgtagtatg  tgtgtccta  acctttctc  ttctttata  2880
ccaaataaa  ttcttacag  aagttattt  tgtgtgtgc  tgattaata  ctcctagca  2940
gactctgag  accaagtaa  agaatgata  aacgaaatt  ttatcttgg  tctgtagga  3000
tgtccaggt  atcatcgat  cttctgatg  ataataaga  aggtaa  3046



<210> 8623
<211> 87
<212> PRT
<213> Rattus norvegicus
<308> AAC99551
<400> 8623

Met Arg Thr Leu Thr Leu Leu Thr Thr Leu Leu Leu Leu Ala Leu His 
  1               5                  10                  15
Thr Gln Ala Glu Ser Pro Gln Gly Ser Thr Lys Glu Ala Pro Asp Glu 
             20                  25                  30
Glu Gln Asp Ile Ser Val Phe Phe Gly Gly Asp Lys Gly Thr Ala Leu 
         35                  40                  45
Gln Asp Ala Ala Val Lys Ala Gly Val Thr Cys Ser Cys Arg Thr Ser 
     50                  55                  60
Ser Cys Arg Phe Gly Glu Arg Leu Ser Gly Ala Cys Arg Leu Asn Gly 
 65                  70                  75                  80
Arg Ile Tyr Arg Leu Cys Cys 
                 85



<210> 8624
<211> 449
<212> DNA
<213> Homo sapiens
<308> NM_021010
<400> 8624

atatccact  ctgctctcc  tcctgcagg  gaccccagc  atgaggacc  tcgccatcc  60
tgctgccat  ctcctggtg  ccctgcagg  ccaggctga  tcactccag  aaagagctg  120
tgaggctac  acccagaag  agtctgggg  agacaacca  gaccttgct  tctcctttg  180
aggaaatgg  ctctctgct  ttagaacct  aggttctca  gcaagagcc  cctgctatt  240
ccgaaccgg  cgttgtgct  cccgtgagt  cctctccgg  gtgtgtgaa  tcagtggcc  300
cctctacag  ctctgctgt  gctgagctt  ctagataga  accaaagca  tgcaagatt  360
agttcaagg  cctgaaaaa  gaaaaacat  ttactctgt  taccttgtg  ctttctaaa  420
ttctctctc  aaaataaag  tcaagcatt  449



<210> 8625
<211> 94
<212> PRT
<213> Homo sapiens
<308> NP_066290
<400> 8625

Met Arg Thr Ile Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
  1               5                  10                  15
Ala Gln Ala Glu Ser Leu Gln Glu Arg Ala Asp Glu Ala Thr Thr Gln 
             20                  25                  30
Lys Gln Ser Gly Glu Asp Asn Gln Asp Leu Ala Ile Ser Phe Ala Gly 
         35                  40                  45
Asn Gly Leu Ser Ala Leu Arg Thr Ser Gly Ser Gln Ala Arg Ala Thr 
     50                  55                  60
Cys Tyr Cys Arg Thr Gly Arg Cys Ala Thr Arg Glu Ser Leu Ser Gly 
 65                  70                  75                  80
Val Cys Glu Ile Ser Gly Arg Leu Tyr Arg Leu Cys Cys Arg 
                 85                  90



<210> 8626
<211> 1563
<212> DNA
<213> Rattus norvegicus
<308> U50412
<400> 8626

cgcctcggg  gctggagcc  cttggtaga  gaacagctt  tttggattt  ttttccccg  60
tgggatact  gcagttcaa  gcgaaaccg  tgaaatgca  aacctgcaa  cactgcccc  120
taaaccacc  aagcccact  ctatagcca  caacagcat  aacaacaat  tgtccttac  180
ggatgctga  tggtactgg  gagatatct  aagggaaga  gtaaatgaa  aactccgag  240
cactgctga  gggaccttt  tggtacgag  tgcatccac  aaaatgcac  gtgactaca  300
tctcacact  aggaaagga  gaaataaca  atcaatcaa  atctttcac  gagatggga  360
atacggttt  tctgatcca  taaccttca  ctctgtggt  gaattaata  cccactacc  420
gaatgagtc  ttagctcag  acaatccca  gctggatgt  aagttactc  acccagtgt  480
taaatacca  caggatcaa  ttgtcaagg  agataatat  gaagctgta  ggaaaaaat  540
acatgaata  aatactcaa  ttcaagaaa  aagtcggga  tatgataga  tatatgagg  600
atacatccg  acttcccag  aaatacaga  gaaaagaac  gctatcgaa  catttaatg  660
aaccataaa  atattcgaa  agcagtgcc  aacccagga  cggtacagc  aagaataca  720
agagaagtt  aaacgcgaa  gcaacgaga  ggaaattca  aggataatg  ataatcacg  780
taagctgaa  tctcggatc  gcgagatca  cgacagcag  aggagactg  aggaagact  840
gaagaagca  gcagccgag  atcgcgaga  cgacaagcg  atgaatagc  ttaagccgg  900
cctcattca  ctgagaaag  caagagatc  atacttgat  tggctgacg  agaaagggg  960
ccggcagaa  aagctgaac  aatggttgg  aaacgaaaa  acagaagac  aatactcac  1020
gctagaaga  gacgaggat  tgccccacc  tgatgagaa  acgtggaat  tggggagca  1080
caaccgaaa  aaagccgag  acctattgc  agggaaacg  gatggcact  tcctggtcc  1140
ggagagcag  aagcagggc  gctatgcct  ctctgtagt  gtagatggc  aagtcaaac  1200
ttgcgtcat  aacaagact  ccaccggct  tggcttcgc  gagccctac  acctgtaca  1260
ctccctgaa  gagctggtg  tacattacc  acacacctc  ctggtgcag  acaatgact  1320
cctcaatgt  acactagca  acccagtat  tgcacaaca  aggcgatga  gcgctgccc  1380
ccctcggat  cagttcctc  ccttcaagc  acccaaggc  tctgggaag  aaagggctc  1440
tctccagcc  gacctgtga  ctgagctgc  gaatcgaag  cggatgtct  cacatggga  1500
tagagcttt  ttggacaaa  agaagtcgg  gaagacatg  agcctaggg  tgttggatg  1560
ccg  1563



<210> 8627
<211> 724
<212> PRT
<213> Rattus norvegicus
<308> Q63787
<400> 8627

Met Ser Ala Glu Gly Tyr Gln Tyr Arg Ala Leu Tyr Asp Tyr Lys Lys 
  1               5                  10                  15
Glu Arg Glu Glu Asp Ile Asp Leu His Leu Gly Asp Ile Leu Thr Val 
             20                  25                  30
Asn Lys Gly Ser Leu Val Ala Leu Gly Phe Ser Asp Gly Gln Glu Ala 
         35                  40                  45
Arg Pro Glu Asp Ile Gly Trp Leu Asn Gly Tyr Asn Glu Thr Thr Gly 
     50                  55                  60
Glu Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Tyr Ile Gly Arg Lys 
 65                  70                  75                  80
Arg Ile Ser Pro Pro Thr Pro Lys Pro Arg Pro Pro Arg Pro Leu Pro 
                 85                  90                  95
Val Ala Pro Gly Ser Ser Lys Thr Glu Ala Asp Thr Glu Gln Pro Val 
             100                105                110
Leu Thr Leu Pro Asp Leu Ala Glu Gln Phe Ala Pro Pro Asp Val Ala 
         115                120                125
Pro Pro Leu Leu Ile Lys Leu Leu Glu Ala Ile Glu Lys Lys Gly Leu 
     130                135                140
Glu Cys Ser Thr Leu Tyr Arg Thr Gln Ser Ser Ser Asn Pro Ala Glu 
 145                150                155                160
Leu Arg Gln Leu Leu Asp Cys Asp Pro Pro Ser Val Asp Leu Asp Val 
                 165                170                175
Phe Asp Glu His Val Leu Ala Asp Ala Phe Lys Arg Tyr Leu Ala Asp 
             180                185                190
Leu Pro Asn Pro Val Ile Pro Val Ala Val Tyr Asn Glu Met Met Ser 
         195                200                205
Leu Ala Gln Glu Val Pro Ser Ser Glu Asp Tyr Ile Gln Leu Leu Lys 
     210                215                220
Lys Leu Ile Arg Ser Pro Asn Ile Pro His Gln Tyr Trp Leu Thr Leu 
 225                230                235                240
Gln Tyr Leu Leu Lys His Phe Phe Lys Leu Ser Gln Ala Ser Ser Lys 
                 245                250                255
Asn Leu Leu Asn Ala Arg Ala Leu Ser Glu Ile Phe Ser His Val Leu 
             260                265                270
Phe Arg Phe Pro Ala Ala Ser Ser Asp Asn Thr Glu His Leu Ile Lys 
         275                280                285
Ala Val Glu Leu Leu Ile Ser Ala Glu Trp Ser Glu Arg Gln Pro Ala 
     290                295                300
Pro Ala Leu Pro Pro Lys Pro Pro Lys Pro Thr Ser Ile Ala Asn Asn 
 305                310                315                320
Ser Met Asn Asn Asn Met Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly 
                 325                330                335
Asp Ile Ser Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Ala Asp 
             340                345                350
Gly Thr Phe Leu Val Arg Asp Ala Ser Thr Lys Met His Gly Asp Tyr 
         355                360                365
Thr Leu Thr Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Ile Phe 
     370                375                380
His Arg Asp Gly Lys Tyr Gly Phe Ser Asp Pro Leu Thr Phe Asn Ser 
 385                390                395                400
Val Val Glu Leu Ile Asn His Tyr Arg Asn Glu Ser Leu Ala Gln Tyr 
                 405                410                415
Asn Pro Lys Leu Asp Val Lys Leu Leu Tyr Pro Val Ser Lys Tyr Gln 
             420                425                430
Gln Asp Gln Val Val Lys Glu Asp Asn Ile Glu Ala Val Gly Lys Lys 
         435                440                445
Leu His Glu Tyr Asn Thr Gln Phe Gln Glu Lys Ser Arg Glu Tyr Asp 
     450                455                460
Arg Leu Tyr Glu Glu Tyr Thr Arg Thr Ser Gln Glu Ile Gln Met Lys 
 465                470                475                480
Arg Thr Ala Ile Glu Ala Phe Asn Asp Thr Ile Lys Ile Phe Glu Glu 
                 485                490                495
Gln Cys His Pro Gln Glu Arg Tyr Ser Lys Asp Tyr Ile Glu Lys Phe 
             500                505                510
Lys Arg Glu Gly Asn Glu Lys Glu Ile Gln Arg Ile Met His Asn His 
         515                520                525
Asp Lys Leu Lys Ser Arg Ile Ser Glu Ile Ile Asp Ser Arg Arg Arg 
     530                535                540
Leu Glu Glu Asp Leu Lys Lys Gln Ala Ala Glu Tyr Arg Glu Ile Asp 
 545                550                555                560
Lys Arg Met Asn Ser Ile Lys Pro Asp Leu Ile Gln Leu Arg Lys Thr 
                 565                570                575
Arg Asp Gln Tyr Leu Met Trp Leu Thr Gln Lys Gly Val Arg Gln Lys 
             580                585                590
Lys Leu Asn Glu Trp Leu Gly Asn Glu Asn Thr Glu Asp Gln Tyr Ser 
         595                600                605
Leu Val Asp Asp Asp Glu Asp Leu Pro His His Asp Glu Lys Thr Trp 
     610                615                620
Asn Val Gly Ser Ser Asn Arg Asn Lys Ala Glu Asn Leu Leu Arg Gly 
 625                630                635                640
Lys Arg Asp Gly Thr Phe Leu Val Arg Glu Ser Ser Lys Gln Gly Cys 
                 645                650                655
Tyr Ala Cys Ser Val Val Val Asp Gly Glu Val Lys His Cys Val Ile 
             660                665                670
Asn Lys Thr Ala Thr Gly Tyr Gly Phe Ala Glu Pro Tyr Asn Leu Tyr 
         675                680                685
Ser Ser Leu Lys Glu Leu Val Leu His Tyr Gln His Thr Ser Leu Val 
     690                695                700
Gln His Asn Asp Ser Leu Asn Val Thr Leu Ala Tyr Pro Val Tyr Ala 
 705                710                715                720
Gln Gln Arg Arg 
                 725



<210> 8628
<211> 3362
<212> DNA
<213> Homo sapiens
<308> XM_043865
<400> 8628

tacaaccag  ctcaactgt  gcatggtag  agatttgca  acatgagtg  tgaggggta  60
cagtacaga  cgctgtatg  ttataaaaa  gaaagagaa  aagatattg  cttgcactt  120
ggtgacata  tgactgtga  taaagggtc  ttagtagct  ttggattca  tgatggaca  180
gaagccagg  ctgaagaaa  tggctggtt  aatggctat  atgaaacca  aggggaaag  240
ggggacttt  cgggaactt  cgtagaata  attggaagg  aaaaaatct  gcctcccac  300
ccaaagccc  ggccacctc  gcctcttcc  gttgcacca  gttcttcga  aactgaagc  360
gatgttgaa  aacaagctt  gactctccc  gatcttgca  agcagtttg  ccctcctga  420
attgccccg  ctcttctta  caagctcgt  gaagccatt  aaaagaaag  tctggaatg  480
tcaactcta  acagaacac  gagctccag  aacctggca  aattacgac  gcttcttga  540
tgtgataca  cctccgtgg  cttggaaat  atcgatgtg  acgttttgg  tgacgcttt  600
aaacgctat  tcctggact  accaaatcc  gtcattcca  cagccgttt  cagtgaaat  660
atttcttta  ctccagaag  acaaagctc  gaagaatat  ttcagctat  gaagaagct  720
attaggtcg  ctagcatac  tcatcagta  tggcttacg  ttcagtatt  gttaaaaca  780
ttcttcaag  tctctcaaa  ctccagcaa  aatctgttg  atgcaagag  actctctga  840
attttcagc  ctatgcttt  cagattctc  gcagccagc  ctgataata  tgaaaacct  900
ataaaagtt  tagaaattt  aatctcaac  gaatggaat  aacgacagc  tgcaccagc  960
ctgcctcct  aaccaccaa  acctactac  gtagccaac  acggtatga  taacaatat  1020
tccttacaa  atgctgaat  gtactgggg  gatatctcg  gggaagaag  gaatgaaaa  1080
cttcgagat  cagcagacg  gaccttttt  gtacgagat  cgtctacta  aatgcatgg  1140
gattatact  ttacactaa  gaaaggggg  aataacaaa  taatcaaaa  atttcatcg  1200
gatgggaaa  atggcttct  tgacccatt  accttcagt  ctgtggttg  attaataaa  1260
cactaccgg  atgaatctc  agctcagta  aatcccaaa  tggatgtga  attacttta  1320
ccagtatcc  aataccaac  ggatcaagt  gtcaaagaa  ataatattg  agctgtagg  1380
aaaaaatta  atgaatata  cactcagtt  caagaaaaa  gtcgagaat  tgatagatt  1440
tatgaagaa  atacccgca  atcccagga  atccaaatg  aaaggacag  tattgaagc  1500
tttaatgaa  ccataaaaa  atttgaaga  cagtgccag  cccaagagc  gtacagcaa  1560
gaatacata  aaaagttta  acgtgaagg  aatgagaaa  aaatacaaa  gattatgca  1620
aattatgat  agttgaagt  tcgaatcag  gaaattatt  acagtagaa  aagattgga  1680
gaagacttg  agaagcagg  agctgagta  cgagaaatt  acaaacgta  gaacagcat  1740
aaaccagac  ttatccagc  gagaaagac  agagaccaa  acttgatgt  gttgactca  1800
aaaggtgtt  ggcaaaaga  gttgaacga  tggttgggc  atgaaaaca  tgaagacca  1860
tattcactg  tggaagatg  tgaagattt  ccccatcat  atgagaaga  atggaatgt  1920
ggaagcagc  accgaaaca  agctgaaaa  ctgttgcga  ggaagcgag  tggcacttt  1980
cttgtccgg  agagcagta  acagggctg  tatgcctgc  ctgtagtgg  ggacggcga  2040
gtaaagcat  gtgtcataa  caaaacagc  actggctat  gctttgccg  gccctataa  2100
ttgtacagc  ctctgaaag  actggtgct  cattaccaa  acacctccc  tgtgcagca  2160
aacgactcc  tcaatgtca  actagccta  ccagtatat  cacagcaga  gcgatgaag  2220
gcttactct  tgatccttc  cctgaagtt  agccaccct  aggcctctg  aaagcaaag  2280
gctcctctc  agtctgatc  gtgaattga  ctgcagaaa  gaagccatc  ttctttgga  2340
gggactaga  ctttctttc  caaaaaaga  gtaggggaa  acatgcagc  taaggctgt  2400
tgatgacca  acgttccta  gctggagtg  ttatccctt  tttttcttt  tttctttgg  2460
ttaatttaa  gccacaacc  catacaaca  aaagagaaa  agaaatgca  aaatctctg  2520
gtgcaggga  aaagaggcc  ttaaccatg  tgcttgtta  tgctttctg  agctttacc  2580
gctgaaagt  gggactctg  agagcggag  agagagagg  agaagaacc  tggcctgag  2640
aggtttggt  cagcctggt  tagcctgga  gttgctgtg  acggtggac  cagacacat  2700
gcactgtgg  ttatttcat  ttgtaacaa  tgaacgata  gtagcagaa  ggcacgtcc  2760
ctcacaagg  acgctttgg  agaatgtca  ttcatgtat  ttcagaaga  attctgtca  2820
agaaagtgc  agaaagtgt  taacttgtc  aaaaacaaa  acccagcaa  agaaaaatg  2880
agtttggaa  acaggactt  aaatgacat  cagtatata  aatatgtac  taatattgg  2940
tgactaact  tcaaataga  ggatttgta  caataccaa  tagcttctg  tttgttttg  3000
tgaaggcta  attcacagc  ctatgcaat  cttaatttt  attaagttg  tatttcagt  3060
ttaaatgta  cttcagaat  agcttcccc  ccccagttt  tgttgcttg  aaatattgt  3120
gtcccggat  tttgttaat  ttcattttt  ttatccttt  ttaaaagta  atgtacagg  3180
tgccagtaa  aaaaaaaaa  ggcttcaga  ttaaaacta  gaaatattt  acagttttt  3240
ttgtacaga  tacttggct  ttagcccaa  gttaaaaag  tcataacag  ttttttttg  3300
actgttttg  tgggcagtg  ctgataagc  tcaaagctg  tttattcaa  aaaaaaaag  3360
aa  3362



<210> 8629
<211> 724
<212> PRT
<213> Homo sapiens
<308> XP_043865
<400> 8629

Met Ser Ala Glu Gly Tyr Gln Tyr Arg Ala Leu Tyr Asp Tyr Lys Lys 
  1               5                  10                  15
Glu Arg Glu Glu Asp Ile Asp Leu His Leu Gly Asp Ile Leu Thr Val 
             20                  25                  30
Asn Lys Gly Ser Leu Val Ala Leu Gly Phe Ser Asp Gly Gln Glu Ala 
         35                  40                  45
Arg Pro Glu Glu Ile Gly Trp Leu Asn Gly Tyr Asn Glu Thr Thr Gly 
     50                  55                  60
Glu Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Tyr Ile Gly Arg Lys 
 65                  70                  75                  80
Lys Ile Ser Pro Pro Thr Pro Lys Pro Arg Pro Pro Arg Pro Leu Pro 
                 85                  90                  95
Val Ala Pro Gly Ser Ser Lys Thr Glu Ala Asp Val Glu Gln Gln Ala 
             100                105                110
Leu Thr Leu Pro Asp Leu Ala Glu Gln Phe Ala Pro Pro Asp Ile Ala 
         115                120                125
Pro Pro Leu Leu Ile Lys Leu Val Glu Ala Ile Glu Lys Lys Gly Leu 
     130                135                140
Glu Cys Ser Thr Leu Tyr Arg Thr Gln Ser Ser Ser Asn Leu Ala Glu 
 145                150                155                160
Leu Arg Gln Leu Leu Asp Cys Asp Thr Pro Ser Val Asp Leu Glu Met 
                 165                170                175
Ile Asp Val His Val Leu Ala Asp Ala Phe Lys Arg Tyr Leu Leu Asp 
             180                185                190
Leu Pro Asn Pro Val Ile Pro Ala Ala Val Tyr Ser Glu Met Ile Ser 
         195                200                205
Leu Ala Pro Glu Val Gln Ser Ser Glu Glu Tyr Ile Gln Leu Leu Lys 
     210                215                220
Lys Leu Ile Arg Ser Pro Ser Ile Pro His Gln Tyr Trp Leu Thr Leu 
 225                230                235                240
Gln Tyr Leu Leu Lys His Phe Phe Lys Leu Ser Gln Thr Ser Ser Lys 
                 245                250                255
Asn Leu Leu Asn Ala Arg Val Leu Ser Glu Ile Phe Ser Pro Met Leu 
             260                265                270
Phe Arg Phe Ser Ala Ala Ser Ser Asp Asn Thr Glu Asn Leu Ile Lys 
         275                280                285
Val Ile Glu Ile Leu Ile Ser Thr Glu Trp Asn Glu Arg Gln Pro Ala 
     290                295                300
Pro Ala Leu Pro Pro Lys Pro Pro Lys Pro Thr Thr Val Ala Asn Asn 
 305                310                315                320
Gly Met Asn Asn Asn Met Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly 
                 325                330                335
Asp Ile Ser Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Ala Asp 
             340                345                350
Gly Thr Phe Leu Val Arg Asp Ala Ser Thr Lys Met His Gly Asp Tyr 
         355                360                365
Thr Leu Thr Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Ile Phe 
     370                375                380
His Arg Asp Gly Lys Tyr Gly Phe Ser Asp Pro Leu Thr Phe Ser Ser 
 385                390                395                400
Val Val Glu Leu Ile Asn His Tyr Arg Asn Glu Ser Leu Ala Gln Tyr 
                 405                410                415
Asn Pro Lys Leu Asp Val Lys Leu Leu Tyr Pro Val Ser Lys Tyr Gln 
             420                425                430
Gln Asp Gln Val Val Lys Glu Asp Asn Ile Glu Ala Val Gly Lys Lys 
         435                440                445
Leu His Glu Tyr Asn Thr Gln Phe Gln Glu Lys Ser Arg Glu Tyr Asp 
     450                455                460
Arg Leu Tyr Glu Glu Tyr Thr Arg Thr Ser Gln Glu Ile Gln Met Lys 
 465                470                475                480
Arg Thr Ala Ile Glu Ala Phe Asn Glu Thr Ile Lys Ile Phe Glu Glu 
                 485                490                495
Gln Cys Gln Thr Gln Glu Arg Tyr Ser Lys Glu Tyr Ile Glu Lys Phe 
             500                505                510
Lys Arg Glu Gly Asn Glu Lys Glu Ile Gln Arg Ile Met His Asn Tyr 
         515                520                525
Asp Lys Leu Lys Ser Arg Ile Ser Glu Ile Ile Asp Ser Arg Arg Arg 
     530                535                540
Leu Glu Glu Asp Leu Lys Lys Gln Ala Ala Glu Tyr Arg Glu Ile Asp 
 545                550                555                560
Lys Arg Met Asn Ser Ile Lys Pro Asp Leu Ile Gln Leu Arg Lys Thr 
                 565                570                575
Arg Asp Gln Tyr Leu Met Trp Leu Thr Gln Lys Gly Val Arg Gln Lys 
             580                585                590
Lys Leu Asn Glu Trp Leu Gly Asn Glu Asn Thr Glu Asp Gln Tyr Ser 
         595                600                605
Leu Val Glu Asp Asp Glu Asp Leu Pro His His Asp Glu Lys Thr Trp 
     610                615                620
Asn Val Gly Ser Ser Asn Arg Asn Lys Ala Glu Asn Leu Leu Arg Gly 
 625                630                635                640
Lys Arg Asp Gly Thr Phe Leu Val Arg Glu Ser Ser Lys Gln Gly Cys 
                 645                650                655
Tyr Ala Cys Ser Val Val Val Asp Gly Glu Val Lys His Cys Val Ile 
             660                665                670
Asn Lys Thr Ala Thr Gly Tyr Gly Phe Ala Glu Pro Tyr Asn Leu Tyr 
         675                680                685
Ser Ser Leu Lys Glu Leu Val Leu His Tyr Gln His Thr Ser Leu Val 
     690                695                700
Gln His Asn Asp Ser Leu Asn Val Thr Leu Ala Tyr Pro Val Tyr Ala 
 705                710                715                720
Gln Gln Arg Arg 
                 725



<210> 8630
<211> 1749
<212> DNA
<213> Rattus norvegicus
<308> U50736
<400> 8630

cccgggcag  tccaggggt  cagccacaa  agggaaaaa  atagactaa  ggctgccaa  60
atgatggtt  ttcgagtag  ggagctggt  acgggcaaa  agaacagca  tgggtcctc  120
ggggagttc  ttcctggcg  gttcagaaa  ggagagtat  aagctgctg  tgccttgga  180
aaacaagag  acttgaaga  acttccagc  aacagtgtg  acctggggg  agaacaacg  240
aaaagtgag  aagttcgag  ggcagagct  aaaaagaaa  aactagaac  aagatcaaa  300
cttgaaaac  tagaagacc  tgaaataat  gttcaactg  agaaaagaa  aaaatacaa  360
aaaactaaa  ttccagttg  gaaggaacc  gagcctgaa  ttattactg  acctgtgga  420
gtgccaagg  ttctgaaag  tgcactgga  aacaaactg  cagttgtag  gaaattcct  480
tcagacaag  acagccccg  cgtctgcga  gagtataaa  ggaccgctc  ccatagagc  540
tgcttagaa  gacacttgg  gatcgtgga  aagttaatg  aggctggag  ccagattga  600
ttccgagat  tgctggaat  cacagccat  cactgggca  gtcgtggag  aaacctgga  660
gtcctgaaa  tgttgctaa  caaaggtgc  aaaatcagt  cccgagaca  gctgctcag  720
acagcgctg  acgtggcgg  gaggaccgg  cactacgag  gtgctgagc  cctcatcgc  780
tgcgaggcg  atctcaatg  caaggacag  gaaggagac  cccctctgc  tgatgcggt  840
aggttgaat  gctacaaga  gatccggct  ttgatgacc  tcggtgcgg  cctcaatgt  900
aagaactgt  ctgggaaga  ccctatgga  ctggtgttg  actggcaga  tggaaccaa  960
gcgatattc  acagcctca  ggagaatgc  tacaaaaac  cgcgcatag  tacgttctg  1020
ggaaagaga  tcgacagga  ctgttctca  ccgttttca  aacatttcc  agcagcgga  1080
caaccagct  taacaccca  cttttgttt  ccagccaaa  agggagata  gctttaaag  1140
cgcttcatg  aaggaccct  ggttagaga  gctaacatg  cctctagcg  tgctcacca  1200
ttttatctg  tcctattta  ttatttatt  atttcatag  actggtagt  aggttttca  1260
gagcatcat  ttgggggag  aagacttaa  ctgtgtgta  cattcggag  cttcccgtg  1320
ctctaaaac  gcgtgggtg  atggtgtct  atctccctt  tgtgtcctc  cttgcatta  1380
agctactca  ggtattttt  aaagccaag  gttggtcgg  cgctgcagc  cttctctgg  1440
ttctcactg  tgatatccg  atgaagcag  agaaggtgt  caggaatgc  gaaggggat  1500
ggagcagtt  tgcaggacc  aagccgtgg  tcgccaggc  cccacaggt  tggtttgcc  1560
gatcacaca  tgccgaggt  aaggccacg  caggagcgt  tgtggaggg  gatggaggg  1620
gtaggcaat  gggcctcac  aacctgagg  cgatgagag  aaaaagtcc  aaaggacat  1680
ccctgtaaa  gtgtaaatg  tattgtgtt  tatgcatat  ttatattcc  aataaatgc  1740
aactaattc  1749



<210> 8631
<211> 320
<212> PRT
<213> Rattus norvegicus
<308> U50736
<400> 8631

Met Met Val Phe Arg Val Glu Glu Leu Val Thr Gly Lys Lys Asn Ser 
  1               5                  10                  15
Asn Gly Ser Ser Gly Glu Phe Leu Pro Gly Glu Phe Arg Asn Gly Glu 
             20                  25                  30
Tyr Glu Ala Ala Val Ala Leu Glu Lys Gln Glu Asp Leu Lys Thr Leu 
         35                  40                  45
Pro Ala Asn Ser Val Asn Leu Gly Glu Glu Gln Arg Lys Ser Glu Lys 
     50                  55                  60
Val Arg Glu Ala Glu Leu Lys Lys Lys Lys Leu Glu Gln Arg Ser Lys 
 65                  70                  75                  80
Leu Glu Asn Leu Glu Asp Leu Glu Ile Ile Val Gln Leu Lys Lys Arg 
                 85                  90                  95
Lys Lys Tyr Lys Lys Thr Lys Val Pro Val Val Lys Glu Pro Glu Pro 
             100                105                110
Glu Ile Ile Thr Glu Pro Val Asp Val Pro Arg Phe Leu Lys Ala Ala 
         115                120                125
Leu Glu Asn Lys Leu Pro Val Val Glu Lys Phe Leu Ser Asp Lys Asn 
     130                135                140
Ser Pro Asp Val Cys Asp Glu Tyr Lys Arg Thr Ala Leu His Arg Ala 
 145                150                155                160
Cys Leu Glu Gly His Leu Ala Ile Val Glu Lys Leu Met Glu Ala Gly 
                 165                170                175
Ala Gln Ile Glu Phe Arg Asp Met Leu Glu Ser Thr Ala Ile His Trp 
             180                185                190
Ala Cys Arg Gly Gly Asn Leu Asp Val Leu Lys Leu Leu Leu Asn Lys 
         195                200                205
Gly Ala Lys Ile Ser Ala Arg Asp Lys Leu Leu Ser Thr Ala Leu His 
     210                215                220
Val Ala Val Arg Thr Gly His Tyr Glu Cys Ala Glu His Leu Ile Ala 
 225                230                235                240
Cys Glu Ala Asp Leu Asn Ala Lys Asp Arg Glu Gly Asp Thr Pro Leu 
                 245                250                255
His Asp Ala Val Arg Leu Asn Arg Tyr Lys Met Ile Arg Leu Leu Met 
             260                265                270
Thr Phe Gly Ala Asp Leu Asn Val Lys Asn Cys Ala Gly Lys Ile Pro 
         275                280                285
Met Asp Leu Val Leu His Trp Gln Asn Gly Thr Lys Ala Ile Phe Asp 
     290                295                300
Ser Leu Lys Glu Asn Ala Tyr Lys Asn Ser Arg Ile Ala Thr Phe Ter 
 305                310                315                320



<210> 8632
<211> 476
<212> DNA
<213> Homo sapiens
<308> BF081129
<400> 8632

cgtatctcc  ttctctgtc  ttggcgttg  ggtctgcct  acaggcgat  agatgctcc  60
cgcactcat  gtggccagt  ctcaccgcc  catgcagcg  tgtgctgag  aacttatct  120
gggcgctaa  ttttgctcc  ttattcagc  acaatttta  aacatccag  tttcctcca  180
ggcttgccc  gtgaatggc  gtggattca  gcatatcac  gaattcgat  tgggctcca  240
cttccatta  cttctccac  attgccaaa  gtccttcca  gcatgctct  tgaagagct  300
tccgtttat  aatgatttc  ggttctggt  cctttacaa  tggaacttt  gttttcctg  360
attttttcc  tttcttcag  tgaatgatt  tttcaaggt  ttctaaatt  tcaagcttt  420
atcttttgt  ctagttttt  ctttttgag  tctgcctct  gttgtttct  gctttt  476



<210> 8633
<211> 2450
<212> DNA
<213> Rattus norvegicus
<308> U51013
<400> 8633

cgcggccgc  cgcgggctg  gcggcggcg  tggcgcaag  cggacggcg  gcgcgcggc  60
cggggccct  gctgggcgg  cgtgctcgg  acggcgcgg  ggccgcgca  ccatggccg  120
ggagctgcg  cgggcgctg  tggagctgc  gacgcgtcc  gggaactcg  gctgcgctg  180
ctgcggagc  ccggatcct  actgggcgt  ctacaccct  ggtgtgttc  tctgtttga  240
ctgctctgg  atccaccgg  acatccccc  ggtcagcaa  gtgaagtca  ttcgtctgg  300
tgcctggga  gagacccaa  ttgagttca  gacatctca  gggaacgag  ctgccagag  360
cacatttga  tccaaagta  cacccttct  ctaccggcc  acgttctcc  actgccaac  420
cctacgtga  cagtggatc  gtgccaagt  tgagaggca  gaattcctt  atgtggaga  480
acaggaacc  tactctaca  gataccgtg  gggccttct  tggaaaggc  gtgggccgg  540
acaatggac  gttcttaag  cggaagttt  tgctgacag  acgagaggg  ggcgtctga  600
atacttcaa  aaaaatgac  ctaaggagc  taaggctgt  atgaagatt  agcacctga  660
tgccacctt  cagccagcc  agatcggcc  cccccatgg  ctgcaggtc  cctacttga  720
ggacaacag  actcgcaac  tctttatct  ccacgagga  ggcaaggag  tcgtggact  780
gttcaatgc  ctgcgagca  cccgcttcc  ctacctgca  gtggctttc  caggagcca  840
tgacgcaga  ctggtgccc  agctctcta  gaactacct  aaggaaggc  acatggaga  900
gacagggcc  aagcagaca  aaggctttc  gaagcgctg  ttcaccatg  acgaccgga  960
gctcatgta  ttcaaagac  ctctggatg  ctttgcccg  ggggaagtc  tcattggca  1020
caaggaaag  ggttacacg  tcctggagg  cctcccacc  tcaacccag  gtcaccact  1080
gccccatgg  atcaccatt  tcacccctg  ccgaaaatt  ctgttcacg  gtgagacag  1140
gtcagacca  agggagtgg  tagcagcct  ccagaaggt  gtggacagg  ccatgctgc  1200
tcaggagta  gcagtggaa  cccacttca  gcatataaa  cctaaggaa  agagcccgg  1260
ggccccagg  ttctgcact  gtgtggcgg  tcagctgga  agcaggaga  cctatgttc  1320
tcggtgtgg  ccaggcatg  ccaggtggg  ctcaggcaa  cccatcaga  agacagatt  1380
ttcagaacc  cattaaagt  gaaggcaga  ttggttctg  gcctcactt  aacccctgg  1440
cctgtcatg  cgctcccag  catgcccag  cgacccacc  attttcctg  tgctggagg  1500
agccctgcc  cccaacttg  gcaggaccc  actaactct  ctggcctga  gggatcttg  1560
cctcaggac  ggacttggt  ctgggctgc  gtggacagc  atggacagc  atgaacagc  1620
gtggcagcg  gctggcctg  ctgctggac  cactctggg  tgtgcagca  gcctcccct  1680
ctctcactc  tccacttca  acaagtata  tattgagct  cctgctgtg  gtcagtcag  1740
gatcaaggg  caggggtca  ctctccttc  cctagggct  acccagctg  agggattgg  1800
ggtcaggta  ttttccaag  gaactgtgt  cataggccc  gcacccacc  gtttgcccc  1860
cccccccac  cccaggccc  ttgggacag  tggctggag  aaccaggga  ggagaccta  1920
cctgcaggg  gctgtgcat  gagcccagg  gcggtttcc  tgggatgac  ggaggcccc  1980
caatccccc  tctgacttt  tggagctgt  agtgcccca  ctcggtgct  tccccagca  2040
tgtaaccca  gccctctgc  ctgccctta  agtctttga  ccccttgat  aatgaaagc  2100
caaggacca  gaagtggtc  ttggcagga  tggctgccc  ccagccctg  ttgctgctg  2160
caggccagt  gttaaagct  cctgtattt  tttccccca  tgccctctg  ccaccccaa  2220
agatgggct  ccttctatg  gatccccaa  agggcaggt  ctggccagc  ggacagctg  2280
ggagcattg  tgggggacc  atctgtgaa  gacctggtc  ctcctcaaa  ctaagccct  2340
gggacctgg  gggaggggt  cttagttgg  cttctgctg  cctgctgtc  tgtcgcctg  2400
aataaagtg  ggctctggc  ttgtaaaaa  aaaaaaaaa  aaaaaaaaaa  2450



<210> 8634
<211> 419
<212> PRT
<213> Rattus norvegicus
<308> AAC52683
<400> 8634

Met Ala Gly Glu Leu Arg Arg Ala Leu Leu Glu Leu Leu Thr Arg Pro 
  1               5                  10                  15
Gly Asn Ser Arg Cys Ala Asp Cys Gly Ala Pro Asp Pro Asp Trp Ala 
             20                  25                  30
Ser Tyr Thr Leu Gly Val Phe Ile Cys Leu Ser Cys Ser Gly Ile His 
         35                  40                  45
Arg Asn Ile Pro Gln Val Ser Lys Val Lys Ser Val Arg Leu Asp Ala 
     50                  55                  60
Trp Asp Glu Thr Gln Val Glu Phe Met Thr Ser His Gly Asn Glu Ala 
 65                  70                  75                  80
Ala Arg Ala Thr Phe Glu Ser Lys Val Pro Pro Phe Tyr Tyr Arg Pro 
                 85                  90                  95
Thr Phe Ser Asp Cys Gln Leu Leu Arg Glu Gln Trp Ile Arg Ala Lys 
             100                105                110
Tyr Glu Arg Gln Glu Phe Leu His Val Glu Lys Gln Glu Pro Tyr Ser 
         115                120                125
Thr Gly Tyr Arg Glu Gly Leu Leu Trp Lys Gly Gly Gly Pro Gly Gln 
     130                135                140
Trp Thr Val Leu Lys Ser Glu Val Cys Ala Asp Arg Thr Arg Gly Trp 
 145                150                155                160
Arg Leu Lys Tyr Phe Asn Lys Asn Asp Ala Lys Glu Pro Lys Ala Val 
                 165                170                175
Met Lys Ile Glu His Leu Asn Ala Thr Phe Gln Pro Ala Lys Ile Gly 
             180                185                190
His Pro His Gly Leu Gln Val Thr Tyr Leu Lys Asp Asn Ser Thr Arg 
         195                200                205
Asn Ile Phe Ile Tyr His Glu Asp Gly Lys Glu Ile Val Asp Trp Phe 
     210                215                220
Asn Ala Leu Arg Ala Ala Arg Phe His Tyr Leu Gln Val Ala Phe Pro 
 225                230                235                240
Gly Ala Ser Asp Ala Asp Leu Val Pro Lys Leu Ser Arg Asn Tyr Leu 
                 245                250                255
Lys Glu Gly Tyr Met Glu Lys Thr Gly Pro Lys Gln Thr Glu Gly Phe 
             260                265                270
Arg Lys Arg Trp Phe Thr Met Asp Asp Arg Arg Leu Met Tyr Phe Lys 
         275                280                285
Asp Pro Leu Asp Ala Phe Ala Arg Gly Glu Val Phe Ile Gly Ser Lys 
     290                295                300
Glu Ser Gly Tyr Thr Val Leu Glu Gly Leu Pro Pro Ser Thr Gln Ser 
 305                310                315                320
His His Trp Pro His Gly Ile Thr Ile Val Thr Pro Asp Arg Lys Phe 
                 325                330                335
Leu Phe Thr Cys Glu Thr Glu Ser Asp Gln Arg Glu Trp Ile Ala Ala 
             340                345                350
Phe Gln Lys Val Val Asp Arg Pro Met Leu Pro Gln Glu Tyr Ala Val 
         355                360                365
Glu Ala His Phe Lys His Ile Asn Pro Lys Glu Glu Ser Pro Glu Ala 
     370                375                380
Pro Gly Phe Cys Thr Arg Val Ala Ala Gln Leu Asp Ser Arg Arg Ala 
 385                390                395                400
Tyr Val Pro Arg Cys Gly Pro Gly Met Ala Arg Trp Gly Ser Gly Lys 
                 405                410                415
Pro Ile Arg 
             420



<210> 8635
<211> 2378
<212> DNA
<213> Homo sapiens
<308> AF082324
<400> 8635

aattccctc  gccgcggtc  ctgagcgag  gcggcggga  tgcggaacc  gcgcgcggg  60
tgaggccgc  cgggatggc  caggggcgg  ggcggcggg  ggcctgcgc  gggccctag  120
gagccgggc  gacgctccc  gccccggcc  cggcatcgg  atcgcgggc  catcgcggc  180
atggccaag  agcggcgca  ggcggtcct  gagctgctg  agcggccgg  gaacgcgcg  240
tgcgcggac  gcggcgccc  ggatcccga  tgggcctcc  acactctgg  cgtcttcat  300
tgcctgagc  gctcgggaa  ccaccggaa  atcccccag  tcagcaagg  gaagtccgt  360
cgcctggac  cctgggagg  ggcccaagt  gagttcatg  cctcccacg  gaacgacgc  420
gcgagagcc  ggtttgagt  caaagtacc  tccttctac  accggccca  gccctccga  480
tgccagctc  ttcgagagc  gtggatccg  gccaagtac  agcgacagg  gttcatcta  540
ccggagaag  aggagccct  ctcggcagg  taccgtgag  gttttctct  gaagcgtgg  600
cgggacaac  ggcagtttt  gagccggaa  tttgtgctg  cagaacgag  gggtgctct  660
aagtatttc  acagaaatg  tgccaagga  cccaaggcc  tgatgaaga  cgagcacct  720
aatgccacc  tccagccgg  caagatcgg  cacccccac  gcctgcagg  cacctacct  780
aaggacaac  gcacccgta  catcttcat  taccatgag  acgggaagg  gattgtgga  840
tggttcaat  cactccgag  tgctcgctt  cactacctg  aggtggcat  cccaggggc  900
agcgacgca  atctggtgc  aaagctctc  aggaactac  tgaaggaag  ctacatgga  960
aagacgggg  ccaagcaaa  ggaaggctt  cggaagcgc  ggttcacca  ggatgaccg  1020
aggctcatg  acttcaaag  ccccctgga  gccttcgcc  gaggggaag  cttcattgg  1080
agcaaggag  gtggctaca  ggtgctgca  gggttcccg  cgtccaccc  gggccacca  1140
tggccacat  gcatcacca  cgtcacgcc  gaccgcaag  ttctgtttg  ctgcgagac  1200
gagtccgac  agagggagt  ggtggcggc  ttccagaag  cggtggaca  gcccatgct  1260
ccccaggag  acgcagtgg  ggcgcactt  aagcataaa  cttagcgag  gcggctgga  1320
gaccacgga  attggactc  ctgtggctg  acggagggg  cccgtggat  ggggggctc  1380
ggcgtcctg  ggccacctg  ccccacctg  tcctcaggg  agcccggcg  ggccaggta  1440
ggcccgagc  tcagcttcc  ggatgcttc  ctggaacct  aaggcaggc  gcccaggcc  1500
tgggcctga  ctctaaccc  gtcatgctg  tgctgacca  acccagcca  cctgcccct  1560
cctgacccg  ggccccctt  cctccaggg  ccagtctgg  tcccgagct  agacacagc  1620
cccaggagc  gcccaccac  gctgtggga  cttccaggc  tcagcgcag  gccctgctt  1680
gggccagca  ggtgggcag  tgccggccg  tggggactg  gccctgctc  catgccgcc  1740
cgccctccc  ccacctcca  gactattta  tgagcgcct  ttgtgtgtc  cggggctat  1800
agggccgtg  ggtgtttgg  tggattatc  acacaggtc  cggcccctg  ccgggctgg  1860
gttgccaca  cctgtgctc  tggtcctca  ctggagggg  cagcaggct  ccgtcccac  1920
acacgtggc  tctgcgccc  gcacggtgc  cgccgacag  ggtgtctga  cccttgggg  1980
cgagggcct  ggccgcggt  aggccacca  aggcaggag  ggccctggg  gtcccgggc  2040
ctgtcgcgc  tgctgcagg  ggcccagcc  tgtatttat  tttcaccta  ctccttcct  2100
tcaaggcag  ccgggctcc  gggctcccc  tgcgtgggg  atgtaggtg  gggaggcgt  2160
tgcaggtca  ctggggggc  cagccctct  ccagccttg  ctggctgag  tgtgttcca  2220
gggagccct  gacaagccc  cataggcag  gagggggtt  ccgaggcca  gcatccgcc  2280
ccccgtgtc  catcctgga  taaaatgtg  ctctggcat  gttaaaaaa  aaaaaaaaa  2340
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  2378



<210> 8636
<211> 374
<212> PRT
<213> Homo sapiens
<308> NP_006860
<400> 8636

Met Ala Lys Glu Arg Arg Arg Ala Val Leu Glu Leu Leu Gln Arg Pro 
  1               5                  10                  15
Gly Asn Ala Arg Cys Ala Asp Cys Gly Ala Pro Asp Pro Asp Trp Ala 
             20                  25                  30
Ser Tyr Thr Leu Gly Val Phe Ile Cys Leu Ser Cys Ser Gly Ile His 
         35                  40                  45
Arg Asn Ile Pro Gln Val Ser Lys Val Lys Ser Val Arg Leu Asp Ala 
     50                  55                  60
Trp Glu Glu Ala Gln Val Glu Phe Met Ala Ser His Gly Asn Asp Ala 
 65                  70                  75                  80
Ala Arg Ala Arg Phe Glu Ser Lys Val Pro Ser Phe Tyr Tyr Arg Pro 
                 85                  90                  95
Thr Pro Ser Asp Cys Gln Leu Leu Arg Glu Gln Trp Ile Arg Ala Lys 
             100                105                110
Tyr Glu Arg Gln Glu Phe Ile Tyr Pro Glu Lys Gln Glu Pro Tyr Ser 
         115                120                125
Ala Gly Tyr Arg Glu Gly Phe Leu Trp Lys Arg Gly Arg Asp Asn Gly 
     130                135                140
Gln Phe Leu Ser Arg Lys Phe Val Leu Thr Glu Arg Glu Gly Ala Leu 
 145                150                155                160
Lys Tyr Phe Asn Arg Asn Asp Ala Lys Glu Pro Lys Ala Val Met Lys 
                 165                170                175
Ile Glu His Leu Asn Ala Thr Phe Gln Pro Ala Lys Ile Gly His Pro 
             180                185                190
His Gly Leu Gln Val Thr Tyr Leu Lys Asp Asn Ser Thr Arg Asn Ile 
         195                200                205
Phe Ile Tyr His Glu Asp Gly Lys Glu Ile Val Asp Trp Phe Asn Ala 
     210                215                220
Leu Arg Ala Ala Arg Phe His Tyr Leu Gln Val Ala Phe Pro Gly Ala 
 225                230                235                240
Ser Asp Ala Asp Leu Val Pro Lys Leu Ser Arg Asn Tyr Leu Lys Glu 
                 245                250                255
Gly Tyr Met Glu Lys Thr Gly Pro Lys Gln Thr Glu Gly Phe Arg Lys 
             260                265                270
Arg Trp Phe Thr Met Asp Asp Arg Arg Leu Met Tyr Phe Lys Asp Pro 
         275                280                285
Leu Asp Ala Phe Ala Arg Gly Glu Val Phe Ile Gly Ser Lys Glu Ser 
     290                295                300
Gly Tyr Thr Val Leu His Gly Phe Pro Pro Ser Thr Gln Gly His His 
 305                310                315                320
Trp Pro His Gly Ile Thr Ile Val Thr Pro Asp Arg Lys Phe Leu Phe 
                 325                330                335
Ala Cys Glu Thr Glu Ser Asp Gln Arg Glu Trp Val Ala Ala Phe Gln 
             340                345                350
Lys Ala Val Asp Arg Pro Met Leu Pro Gln Glu Tyr Ala Val Glu Ala 
         355                360                365
His Phe Lys His Lys Pro 
     370



<210> 8637
<211> 530
<212> DNA
<213> Rattus norvegicus
<308> U52530
<400> 8637

tctagagaa  ggggagcgg  tggcacagc  ccagatctg  accattgac  tctacatgg  60
catggtcaa  tgctggatg  ttgatgaga  tattcgccc  acctttaaa  aactagcca  120
tgagtttac  aggatggcc  gtgacccac  aaggtatct  gtcatcaag  gagcgagtg  180
gcctggaac  cctcctgcg  cagaaccct  tgttctgac  accaaagag  tgcaggagg  240
agagctgga  ccagaactg  acctagacc  agacttgga  gcagaggag  agggcctgg  300
cacctccct  ggttctgct  ccagcttgc  tacgggaac  ctcacccgg  cacgtggga  360
ccagagcct  ttaagtccc  catctgggt  catgcccat  aaccagagc  gtctcggag  420
ggcttgtct  gattctgcg  ttttggggg  tcgtgaaca  ttctcccgt  ccatctctc  480
gcacccaat  ccacggggg  gtccagcat  agagtcatc  gaggggcata  530



<210> 8638
<211> 1339
<212> PRT
<213> Rattus norvegicus
<308> AAC53050
<400> 8638

Met Arg Ala Thr Gly Thr Leu Gln Val Leu Cys Phe Leu Leu Ser Leu 
  1               5                  10                  15
Ala Arg Gly Ser Glu Met Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
             20                  25                  30
Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Asp Asn Gln Tyr Gln Thr 
         35                  40                  45
Leu Tyr Lys Leu Tyr Glu Lys Cys Glu Val Val Met Gly Asn Leu Glu 
     50                  55                  60
Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
 65                  70                  75                  80
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Val 
                 85                  90                  95
Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
             100                105                110
Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
         115                120                125
His Ala Leu Arg Gln Leu Lys Phe Thr Gln Leu Thr Glu Ile Leu Ser 
     130                135                140
Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
 145                150                155                160
Ile Asp Trp Arg Asp Ile Val Arg Val Arg Gly Ala Glu Ile Val Val 
                 165                170                175
Lys Asn Asn Gly Ala Asn Cys Pro Pro Cys His Glu Val Cys Lys Gly 
             180                185                190
Arg Cys Trp Gly Pro Gly Pro Asp Asp Cys Gln Ile Leu Thr Lys Thr 
         195                200                205
Ile Cys Ala Pro Gln Cys Asn Gly Arg Cys Phe Gly Pro Asn Pro Asn 
     210                215                220
Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
 225                230                235                240
Thr Asp Cys Phe Ala Cys Arg Arg Phe Asn Asp Ser Gly Ala Cys Val 
                 245                250                255
Pro Arg Cys Pro Glu Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
             260                265                270
Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
         275                280                285
Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Phe Cys Val Arg Ala 
     290                295                300
Cys Pro Pro Asp Lys Met Glu Val Asp Lys His Gly Leu Lys Met Cys 
 305                310                315                320
Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                 325                330                335
Gly Ser Arg Tyr Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
             340                345                350
Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
         355                360                365
Asn Val Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
     370                375                380
Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
 385                390                395                400
Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                 405                410                415
Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
             420                425                430
Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
         435                440                445
Ile Ser Ala Gly Arg Val Tyr Ile Ser Ala Asn Gln Gln Leu Cys Tyr 
     450                455                460
His His Ser Leu Asn Trp Thr Arg Leu Leu Arg Gly Pro Ser Glu Glu 
 465                470                475                480
Arg Leu Asp Ile Lys Tyr Asp Arg Pro Leu Gly Glu Cys Leu Ala Glu 
                 485                490                495
Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
             500                505                510
Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Glu Gly Val 
         515                520                525
Cys Val Thr His Cys Asn Phe Leu Gln Gly Glu Pro Arg Glu Phe Val 
     530                535                540
His Glu Ala Gln Cys Phe Ser Cys His Pro Glu Cys Leu Pro Met Glu 
 545                550                555                560
Gly Thr Ser Thr Cys Asn Gly Ser Gly Ser Asp Ala Cys Ala Arg Cys 
                 565                570                575
Ala His Phe Arg Asp Gly Pro His Cys Val Asn Ser Cys Pro His Gly 
             580                585                590
Ile Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Ala Gln Asn 
         595                600                605
Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Asn Gly Pro 
     610                615                620
Glu Leu Gln Asp Cys Leu Gly Gln Ala Glu Val Leu Met Ser Lys Pro 
 625                630                635                640
His Leu Val Ile Ala Val Thr Val Gly Leu Ala Val Ile Leu Met Ile 
                 645                650                655
Leu Gly Gly Ser Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln Asn Lys 
             660                665                670
Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu Pro Leu 
         675                680                685
Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe Lys Glu 
     690                695                700
Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe Gly Thr 
 705                710                715                720
Val His Lys Gly Ile Trp Ile Pro Glu Gly Glu Ser Ile Lys Ile Pro 
                 725                730                735
Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser Phe Gln 
             740                745                750
Ala Val Thr Asp His Met Leu Ala Val Gly Ser Leu Asp His Ala His 
         755                760                765
Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln Leu Val 
     770                775                780
Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Lys Gln His 
 785                790                795                800
Arg Glu Thr Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val Gln Ile 
                 805                810                815
Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Ser Met Val His Arg Asp 
             820                825                830
Leu Ala Leu Arg Asn Val Met Leu Lys Ser Pro Ser Gln Val Gln Val 
         835                840                845
Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys Gln Leu 
     850                855                860
Leu His Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu Glu Ser 
 865                870                875                880
Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly 
                 885                890                895
Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr Ala Gly 
             900                905                910
Leu Arg Leu Ala Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu 
         915                920                925
Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met Val Lys 
     930                935                940
Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu Leu Ala 
 945                950                955                960
Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu Val Ile 
                 965                970                975
Lys Arg Ala Ser Gly Pro Gly Thr Pro Pro Ala Ala Glu Pro Ser Val 
             980                985                990
Leu Thr Thr Lys Glu Leu Gln Glu Ala Glu Leu Glu Pro Glu Leu Asp 
         995                1000                1005
Leu Asp Leu Asp Leu Glu Ala Glu Glu Glu Gly Leu Ala Thr Ser Leu 
     1010                1015                1020
Gly Ser Ala Leu Ser Leu Pro Thr Gly Thr Leu Thr Arg Pro Arg Gly 
 1025                1030                1035                1040
Ser Gln Ser Leu Leu Ser Pro Ser Ser Gly Tyr Met Pro Met Asn Gln 
                 1045                1050                1055
Ser Ser Leu Gly Glu Ala Cys Leu Asp Ser Ala Val Leu Gly Gly Arg 
             1060                1065                1070
Glu Gln Phe Ser Arg Pro Ile Ser Leu His Pro Ile Pro Arg Gly Arg 
         1075                1080                1085
Pro Ala Ser Glu Ser Ser Glu Gly His Val Thr Gly Ser Glu Ala Glu 
     1090                1095                1100
Leu Gln Glu Lys Val Ser Val Cys Arg Ser Arg Ser Arg Ser Arg Ser 
 1105                1110                1115                1120
Pro Arg Pro Arg Gly Asp Ser Ala Tyr His Ser Gln Arg His Ser Leu 
                 1125                1130                1135
Leu Thr Pro Val Thr Pro Leu Ser Pro Pro Gly Leu Glu Glu Glu Asp 
             1140                1145                1150
Gly Asn Gly Tyr Val Met Pro Asp Thr His Leu Arg Gly Ala Ser Ser 
         1155                1160                1165
Ser Arg Glu Gly Thr Leu Ser Ser Val Gly Leu Ser Ser Val Leu Gly 
     1170                1175                1180
Thr Glu Glu Glu Asp Glu Asp Glu Glu Tyr Glu Tyr Met Asn Arg Lys 
 1185                1190                1195                1200
Arg Arg Gly Ser Pro Pro Arg Pro Pro Arg Pro Gly Ser Leu Glu Glu 
                 1205                1210                1215
Leu Gly Tyr Glu Tyr Met Asp Val Gly Ser Asp Leu Ser Ala Ser Leu 
             1220                1225                1230
Gly Ser Thr Gln Ser Cys Pro Leu His Pro Met Ala Ile Val Pro Ser 
         1235                1240                1245
Ala Gly Thr Thr Pro Asp Glu Asp Tyr Glu Tyr Met Asn Arg Arg Arg 
     1250                1255                1260
Gly Ala Gly Gly Ala Gly Gly Asp Tyr Ala Ala Met Gly Ala Cys Pro 
 1265                1270                1275                1280
Ala Ala Glu Gln Gly Tyr Glu Glu Met Arg Ala Phe Gln Gly Pro Gly 
                 1285                1290                1295
His His Ala Pro His Val Arg Tyr Ala Arg Leu Lys Thr Leu Arg Ser 
             1300                1305                1310
Leu Glu Ala Thr Asp Ser Ala Phe Asp Asn Pro Asp Tyr Trp His Ser 
         1315                1320                1325
Arg Leu Phe Pro Lys Ala Asn Ala Gln Arg Thr 
     1330                1335



<210> 8639
<211> 4879
<212> DNA
<213> Homo sapiens
<308> M29366
<400> 8639

accaattcg  cagcggttc  ggtggctct  gcctcgatg  cctagccta  gggcccccg  60
gccggactt  gctgggctc  cttcaccct  tgcggagtc  tgagggcga  cgacgctct  120
caggtgctg  gcttgcttt  cagcctggc  cggggctcc  aggtgggca  ctctcaggc  180
gtgtgtcct  ggactctga  tggcctgag  gtgaccggc  atgctgaga  ccaatacca  240
acactgtac  agctctacg  gaggtgtga  gtggtgatg  ggaaccttg  gattgtgct  300
acgggacac  atgccgacc  ctccttcct  cagtggatt  gagaagtga  aggctatgt  360
ctcgtggcc  tgaatgaat  ctctactct  ccattgccc  acctccgcg  ggtgcgagg  420
acccaggtc  acgatggga  gtttgccat  ttcgtcatg  tgaactata  caccaactc  480
agccacgct  tgcgccagc  ccgcttgac  cagctcacc  agattctgt  agggggtgt  540
tatattgag  agaacgata  gctttgtca  atggacaca  ttgactgga  ggacatcgt  600
agggaccga  atgctgaga  agtggtgaa  gacaatggc  gaagctgtc  cccctgtca  660
gaggtttgc  aggggcgat  ctggggtcc  ggatcagaa  actgccaga  attgaccaa  720
accatctgt  ctcctcagt  taatggtca  tgctttggg  ccaacccca  ccagtgctg  780
catgatgag  gtgccgggg  ctgctcagg  cctcaggac  cagactgct  tgcctgccg  840
cacttcaat  acagtggag  ctgtgtacc  cgctgtcca  agcctcttg  ctacaacaa  900
ctaactttc  agctggaac  caatcccca  accaagtat  agtatggag  agtttgtgt  960
gccagctgt  cccataact  tgtggtgga  caaacatcc  gtgtcaggg  ctgtcctcc  1020
gacaagatg  aagtagata  aaatgggct  aagatgtgt  agccttgtg  gggactatg  1080
cccaaagcc  gtgagggaa  aggctctgg  agccgcttc  agactgtgg  ctcgagcaa  1140
attgatgga  ttgtgaact  caccaagat  ctgggcaac  tggactttc  gatcaccgg  1200
ctcaatgga  acccctggc  caagatccc  gccctggac  cagagaagc  caatgtctt  1260
cggacagta  gggagatca  aggttacct  aacatccag  cctggccgc  ccacatgca  1320
aacttcagt  ttttttcca  tttgacaac  attggaggc  gaagcctct  caaccgggg  1380
ttctcattg  tgatcatga  gaacttgaa  gtcacatct  tgggcttcc  atccctgaa  1440
gaaattagt  ctgggcgta  ctatataag  gccaatagg  agctctgct  ccaccactc  1500
ttgaactgg  ccaaggtgc  tcgggggcc  acggaagag  gactagaca  caagcataa  1560
cggccgcgc  gagactgcg  ggcagaggg  aaagtgtgt  acccactgt  ctcctctgg  1620
ggatgctgg  gcccaggcc  tggtcagtg  ttgtcctgt  gaaattata  ccgaggagg  1680
gtctgtgtg  cccactgca  ctttctgaa  ggggagcct  gagaatttg  ccatgaggc  1740
gaatgcttc  cctgccacc  ggaatgcca  cccatggag  gcactgcca  atgcaatgg  1800
tcgggctct  atacttgtg  tcaatgtgc  cattttcga  atgggcccc  ctgtgtgag  1860
agctgcccc  atggagtcc  aggtgccaa  ggcccaatc  acaagtacc  agatgttca  1920
aatgaatgt  ggccctgcc  tgagaactg  acccagggg  gtaaaggac  agagcttca  1980
gactgttta  gacaaacac  ggtgctgat  ggcaaaacc  atctgacaa  ggctttgac  2040
gtgatagca  gattggtag  gattttcat  atgctgggc  gcacttttc  ctactggcg  2100
gggcgccgg  ttcagaata  aagggctat  aggcgatac  tggaacggg  tgagagcat  2160
gagcctctg  accccagtg  gaaggctaa  aaagtcttg  ccagaatct  caaagagac  2220
gagctaagg  agcttaaag  gcttggctc  ggtgtcttt  gaactgtgc  caaaggagt  2280
tggatccct  agggtgaat  aatcaagat  ccagtctgc  ttaaagtca  tgaggacaa  2340
agtggacgg  agagttttc  agctgtgac  gatcatatg  tggccattg  cagcctgga  2400
catgcccac  ttgtaaggc  gctgggact  tgcccaggg  catctctgc  gcttgtcac  2460
caatatttg  ctctgggtt  tctgctgga  catgtgaga  aacaccggg  ggcactggg  2520
ccacagctg  tgctcaact  gggagtaca  attgccaag  gaatgtact  ccttgagga  2580
catggtatg  tgcatagaa  cctggctgc  cgaaacgtg  tactcaagt  acccagtca  2640
gttcaggtg  cagattttg  tgtggctga  ctgctgcct  ctgatgata  gcagctgct  2700
tacagtgag  ccaagactc  aattaagtg  atggccctt  agagtatcc  ctttgggaa  2760
tacacacac  agagtgatg  ctggagcta  ggtgtgaca  tttgggagt  gatgacctt  2820
ggggcagag  cctatgcag  gctacgatt  gctgaagta  cagacctgc  agagaaggg  2880
gagcggttg  cacagcccc  gatctgcac  attgatgtc  acatggtga  ggtcaagtg  2940
tggatgatt  atgagaaca  tcgcccaac  tttaaagaa  tagccaatg  gttcaccag  3000
atggcccga  acccaccac  gtatctggt  ataaagaga  agagtgggc  tggaatagc  3060
cctgggcca  agccccatg  tctgacaaa  aagaagcta  aggaagtag  gctggagcc  3120
gaactagac  tagacctag  cttggaagc  gaggaggac  acctggcaa  caccacact  3180
ggctccgcc  tcagcctac  agttggaac  cttaatcgg  cacgtggga  ccagagcct  3240
ttaagtcca  catctggat  catgcccat  aaccagggt  atcttgggg  gtcttgcca  3300
gagtctgca  tttctggga  cagtgaacg  tgcccccgt  cagtctctc  acacccaat  3360
ccacgggga  gcctggcat  agagtcatc  gaggggcat  taacaggct  tgaggctga  3420
ctccaggag  aagtgtcaa  gtgtagaag  cggagcagg  gccggagcc  acggccacg  3480
ggagatagc  cctaccatt  ccagcgcca  agtctgctg  ctcctgtta  cccactctc  3540
ccacccggg  tagaggaag  ggatgtcaa  ggttatgtc  tgccagata  acacctcaa  3600
ggtactccc  cctcccggg  aggcaccct  tcttcagtg  gtcttagtt  tgtcctggg  3660
actgaagaa  aagatgaag  tgaggagta  gaatacatg  accggagga  aaggcacag  3720
ccacctcat  cccctaggc  aagttccct  gaggagctg  gttatgagt  catggatgt  3780
gggtcagac  tcagtgcct  tctgggcag  acacagagt  gcccactcc  ccctgtacc  3840
atcatgccc  ctgcaggca  aactccaga  gaagactat  aatatatga  tcggcaacg  3900
gatggaggt  gtcctgggg  tgattatgc  gccatgggg  cctgcccag  atctgagca  3960
gggtatgaa  agatgagag  ttttcaggg  cctggacat  aggcccccc  tgtccatta  4020
gcccgccta  aaactctac  tagcttaga  gctacagac  ctgcctttg  taaccctga  4080
tactggcat  gcaggcttt  ccccaaggc  aatgcccag  gaacgtaac  cctgctccc  4140
gtggcactc  gggagcatt  aatggcagc  agtgccttt  gagggtacc  tcttctccc  4200
attccctct  tctcccagg  cccagcccc  tttccccag  cccagacaa  tccattcaa  4260
ctttggagg  ttttaaaca  tttgacaca  aattcttat  gtatgtagc  agctgtgca  4320
tttcttctc  ttcccaacc  caggaaagg  tttccttat  ttgtgtgct  tcccagtcc  4380
attcctcag  ttcttcaca  gcactcctg  agatatgaa  gattactct  catatccct  4440
cctctcagg  tcttgacta  ttggaacta  gctcttatg  gtgcctttg  ttcccatca  4500
actgtcaag  agaggaaag  gaggaaacc  agcagagga  agtgtaatt  tggtttatg  4560
ctcttaacc  cctagaaag  cagaagctt  aaatctgtg  agaaagagg  taggagtag  4620
tattgatta  tatcataat  cagcactta  ctatgagcc  ggcatcata  taaacttca  4680
ctacattat  tcacttagt  ctttatcat  cttaaaaca  ttctgtgac  tacatatta  4740
ctcatttta  acaaaggga  gtcgggcat  gtggctcat  cctgtaatc  cagcacttt  4800
ggaggctga  gcagaagga  tacctgagg  aaggagttt  agaccagct  agccaacat  4860
gtaagaccc  catctcttt  4879



<210> 8640
<211> 1342
<212> PRT
<213> Homo sapiens
<308> P21860
<400> 8640

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
  1               5                  10                  15
Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
             20                  25                  30
Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
         35                  40                  45
Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
     50                  55                  60
Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
 65                  70                  75                  80
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                 85                  90                  95
Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
             100                105                110
Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
         115                120                125
His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
     130                135                140
Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
 145                150                155                160
Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                 165                170                175
Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
             180                185                190
Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
         195                200                205
Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
     210                215                220
Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
 225                230                235                240
Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                 245                250                255
Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
             260                265                270
Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
         275                280                285
Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
     290                295                300
Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
 305                310                315                320
Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                 325                330                335
Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
             340                345                350
Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
         355                360                365
Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
     370                375                380
Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
 385                390                395                400
Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                 405                410                415
Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
             420                425                430
Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
         435                440                445
Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
     450                455                460
His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
 465                470                475                480
Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                 485                490                495
Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
             500                505                510
Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
         515                520                525
Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
     530                535                540
His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
 545                550                555                560
Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                 565                570                575
Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
             580                585                590
Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
         595                600                605
Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
     610                615                620
Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
 625                630                635                640
His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                 645                650                655
Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
             660                665                670
Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
         675                680                685
Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
     690                695                700
Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
 705                710                715                720
Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                 725                730                735
Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
             740                745                750
Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
         755                760                765
Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
     770                775                780
Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
 785                790                795                800
Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                 805                810                815
Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
             820                825                830
Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
         835                840                845
Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
     850                855                860
Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
 865                870                875                880
Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                 885                890                895
Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
             900                905                910
Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
         915                920                925
Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
     930                935                940
Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
 945                950                955                960
Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                 965                970                975
Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
             980                985                990
His Gly Leu Thr Asn Lys Lys Leu Glu Glu Val Glu Leu Glu Pro Glu 
         995                1000                1005
Leu Asp Leu Asp Leu Asp Leu Glu Ala Glu Glu Asp Asn Leu Ala Thr 
     1010                1015                1020
Thr Thr Leu Gly Ser Ala Leu Ser Leu Pro Val Gly Thr Leu Asn Arg 
 1025                1030                1035                1040
Pro Arg Gly Ser Gln Ser Leu Leu Ser Pro Ser Ser Gly Tyr Met Pro 
                 1045                1050                1055
Met Asn Gln Gly Asn Leu Gly Glu Ser Cys Gln Glu Ser Ala Val Ser 
             1060                1065                1070
Gly Ser Ser Glu Arg Cys Pro Arg Pro Val Ser Leu His Pro Met Pro 
         1075                1080                1085
Arg Gly Cys Leu Ala Ser Glu Ser Ser Glu Gly His Val Thr Gly Ser 
     1090                1095                1100
Glu Ala Glu Leu Gln Glu Lys Val Ser Met Cys Arg Ser Arg Ser Arg 
 1105                1110                1115                1120
Ser Arg Ser Pro Arg Pro Arg Gly Asp Ser Ala Tyr His Ser Gln Arg 
                 1125                1130                1135
His Ser Leu Leu Thr Pro Val Thr Pro Leu Ser Pro Pro Gly Leu Glu 
             1140                1145                1150
Glu Glu Asp Val Asn Gly Tyr Val Met Pro Asp Thr His Leu Lys Gly 
         1155                1160                1165
Thr Pro Ser Ser Arg Glu Gly Thr Leu Ser Ser Val Gly Leu Ser Ser 
     1170                1175                1180
Val Leu Gly Thr Glu Glu Glu Asp Glu Asp Glu Glu Tyr Glu Tyr Met 
 1185                1190                1195                1200
Asn Arg Arg Arg Arg His Ser Pro Pro His Pro Pro Arg Pro Ser Ser 
                 1205                1210                1215
Leu Glu Glu Leu Gly Tyr Glu Tyr Met Asp Val Gly Ser Asp Leu Ser 
             1220                1225                1230
Ala Ser Leu Gly Ser Thr Gln Ser Cys Pro Leu His Pro Val Pro Ile 
         1235                1240                1245
Met Pro Thr Ala Gly Thr Thr Pro Asp Glu Asp Tyr Glu Tyr Met Asn 
     1250                1255                1260
Arg Gln Arg Asp Gly Gly Gly Pro Gly Gly Asp Tyr Ala Ala Met Gly 
 1265                1270                1275                1280
Ala Cys Pro Ala Ser Glu Gln Gly Tyr Glu Glu Met Arg Ala Phe Gln 
                 1285                1290                1295
Gly Pro Gly His Gln Ala Pro His Val His Tyr Ala Arg Leu Lys Thr 
             1300                1305                1310
Leu Arg Ser Leu Glu Ala Thr Asp Ser Ala Phe Asp Asn Pro Asp Tyr 
         1315                1320                1325
Trp His Ser Arg Leu Phe Pro Lys Ala Asn Ala Gln Arg Thr 
     1330                1335                1340



<210> 8641
<211> 312
<212> DNA
<213> Rattus norvegicus
<308> U52663
<400> 8641

cttattact  tgcaatttc  acaattttc  gccttcttt  tgcttctca  cagcatata  60
accttttta  actgcacgt  aataaaatt  attagccat  tgtaagttc  cgattttat  120
atgaacgtt  agcccttgg  tagaaaagg  tgagagaca  atttaaaaa  gggccgtct  180
tttttcccc  ttgtctcgt  ttgttttgt  taaagcaga  catgaccgc  agctcgagt  240
aagttctgg  agagtcctg  gaagattcc  aggtatgcc  gtgaccttt  agaatctct  300
tgtctggcc  gg  312



<210> 8642
<211> 976
<212> PRT
<213> Rattus norvegicus
<308> AAC05607
<400> 8642

Met Ala Gly Arg Ala Arg Ser Gly Leu Leu Leu Leu Leu Leu Gly Leu 
  1               5                  10                  15
Leu Ala Leu Gln Ser Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val 
             20                  25                  30
Phe Lys Arg Phe Lys Glu Thr Thr Arg Ser Phe Ser Asn Glu Cys Leu 
         35                  40                  45
Gly Thr Ile Gly Pro Val Thr Pro Leu Asp Ala Ser Asp Phe Ala Leu 
     50                  55                  60
Asp Ile Arg Met Pro Gly Val Thr Pro Lys Glu Ser Asp Thr Tyr Phe 
 65                  70                  75                  80
Cys Met Ser Met Arg Leu Pro Val Asp Glu Glu Ala Phe Val Ile Asp 
                 85                  90                  95
Phe Lys Pro Arg Ala Ser Met Asp Thr Val His His Met Leu Leu Phe 
             100                105                110
Gly Cys Asn Met Pro Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu 
         115                120                125
Gly Thr Cys Thr Asp Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn 
     130                135                140
Ala Pro Pro Thr Arg Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly 
 145                150                155                160
Glu Thr Gly Ser Lys Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile 
                 165                170                175
Ser Ala Phe Arg Asp Asn His Lys Asp Cys Ser Gly Val Ser Val His 
             180                185                190
Leu Thr Arg Val Pro Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met 
         195                200                205
Ser Val Asp Thr Val Ile Pro Pro Gly Glu Lys Val Val Asn Ala Asp 
     210                215                220
Ile Ser Cys Gln Tyr Lys Met Tyr Pro Met His Val Phe Ala Tyr Arg 
 225                230                235                240
Val His Thr His His Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg 
                 245                250                255
Asn Gly Gln Trp Thr Leu Ile Gly Arg Gln Asn Pro Gln Leu Pro Gln 
             260                265                270
Ala Phe Tyr Pro Val Glu His Pro Val Asp Val Thr Phe Gly Asp Ile 
         275                280                285
Leu Ala Ala Arg Cys Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr 
     290                295                300
His Ile Gly Gly Thr Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met 
 305                310                315                320
Tyr Tyr Met Glu Ala Lys Tyr Ala Leu Ser Phe Met Thr Cys Thr Lys 
                 325                330                335
Asn Val Ala Pro Asp Met Phe Arg Thr Ile Pro Ala Glu Ala Asn Ile 
             340                345                350
Pro Ile Pro Val Lys Pro Asp Met Val Met Met His Gly His His Lys 
         355                360                365
Glu Ala Glu Asn Lys Glu Lys Ser Ala Leu Met Gln Gln Pro Lys Gln 
     370                375                380
Gly Glu Glu Glu Val Leu Glu Gln Gly Asp Phe Tyr Ser Leu Leu Ser 
 385                390                395                400
Lys Leu Leu Gly Glu Arg Glu Asp Val His Val His Lys Tyr Asn Pro 
                 405                410                415
Thr Glu Lys Thr Glu Ser Gly Ser Asp Leu Val Ala Glu Ile Ala Asn 
             420                425                430
Val Val Gln Lys Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala 
         435                440                445
Glu His Glu Glu Trp Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His 
     450                455                460
Arg Phe His Gln Leu Glu Ser Thr Leu Arg Pro Ala Glu Ser Arg Ala 
 465                470                475                480
Phe Ser Phe Gln Gln Pro Gly Glu Gly Pro Trp Glu Pro Glu Pro Ser 
                 485                490                495
Gly Asp Phe His Val Glu Glu Glu Leu Asp Trp Pro Gly Val Tyr Leu 
             500                505                510
Leu Pro Gly Gln Val Ser Gly Val Ala Leu Asp Ser Lys Asn Asn Leu 
         515                520                525
Val Ile Phe His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp 
     530                535                540
Ser Lys Phe Val Tyr Gln Gln Arg Gly Leu Gly Pro Ile Glu Glu Asp 
 545                550                555                560
Thr Ile Leu Val Ile Asp Pro Asn Asn Ala Glu Ile Leu Gln Ser Ser 
                 565                570                575
Gly Lys Asn Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Thr Asp 
             580                585                590
Gly Asn Tyr Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu 
         595                600                605
Asp Pro His Ser Lys Glu Gly Pro Leu Leu Ile Leu Gly Arg Ser Met 
     610                615                620
Gln Pro Gly Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala 
 625                630                635                640
Val Glu Pro Ser Thr Gly Ala Val Phe Val Ser Asp Gly Tyr Cys Asn 
                 645                650                655
Ser Arg Ile Val Gln Phe Ser Pro Ser Gly Lys Phe Val Thr Gln Trp 
             660                665                670
Gly Glu Glu Ser Ser Gly Ser Ser Pro Arg Pro Gly Gln Phe Ser Val 
         675                680                685
Pro His Ser Leu Ala Leu Val Pro His Leu Asp Gln Leu Cys Val Ala 
     690                695                700
Asp Arg Glu Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu 
 705                710                715                720
Phe Val Arg Glu Ile Lys His Ala Ser Phe Gly Arg Asn Val Phe Ala 
                 725                730                735
Ile Ser Tyr Ile Pro Gly Phe Leu Phe Ala Val Asn Gly Lys Pro Tyr 
             740                745                750
Phe Gly Asp Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Ser 
         755                760                765
Gly Glu Ile Ile Asp Val Phe Lys Pro Val Arg Lys His Phe Asp Met 
     770                775                780
Pro His Asp Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp 
 785                790                795                800
Ala His Thr Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Met Glu 
                 805                810                815
His Arg Ser Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu 
             820                825                830
Ala Glu Ala Val Val Glu Pro Lys Val Glu Asn Lys Pro Thr Ser Ser 
         835                840                845
Glu Leu Gln Lys Met Gln Glu Lys Gln Lys Leu Ser Thr Glu Pro Gly 
     850                855                860
Ser Gly Val Ser Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val 
 865                870                875                880
Leu Val Leu Leu Ala Ile Val Met Phe Ile Arg Trp Lys Lys Ser Arg 
                 885                890                895
Ala Phe Gly Asp His Asp Arg Lys Leu Glu Ser Ser Ser Gly Arg Val 
             900                905                910
Leu Gly Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn 
         915                920                925
Phe Phe Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Val 
     930                935                940
Ser Thr Glu Gly Ser Asp Gln Glu Lys Asp Glu Asp Asp Gly Thr Glu 
 945                950                955                960
Ser Glu Glu Glu Tyr Ser Ala Pro Leu Pro Lys Pro Ala Pro Ser Ser 
                 965                970                975



<210> 8644
<211> 974
<212> PRT
<213> Homo sapiens
<308> P19021
<400> 8644

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
  1               5                  10                  15
Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
             20                  25                  30
Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
         35                  40                  45
Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
     50                  55                  60
Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
 65                  70                  75                  80
Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                 85                  90                  95
Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
             100                105                110
Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
         115                120                125
Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
     130                135                140
Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
 145                150                155                160
Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                 165                170                175
Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
             180                185                190
Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
         195                200                205
Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
     210                215                220
Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
 225                230                235                240
Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                 245                250                255
Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
             260                265                270
Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
         275                280                285
Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
     290                295                300
Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
 305                310                315                320
Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                 325                330                335
Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
             340                345                350
Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
         355                360                365
Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
     370                375                380
Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
 385                390                395                400
Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                 405                410                415
Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
             420                425                430
Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
         435                440                445
Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
     450                455                460
Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
 465                470                475                480
Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                 485                490                495
His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
             500                505                510
Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
         515                520                525
His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
     530                535                540
Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
 545                550                555                560
Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Glu Lys Asn 
                 565                570                575
Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
             580                585                590
Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
         595                600                605
Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
     610                615                620
Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
 625                630                635                640
Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                 645                650                655
Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
             660                665                670
Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
         675                680                685
Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
     690                695                700
Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
 705                710                715                720
Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                 725                730                735
Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
             740                745                750
Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
         755                760                765
Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
     770                775                780
Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
 785                790                795                800
Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                 805                810                815
Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala 
             820                825                830
Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln 
         835                840                845
Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val 
     850                855                860
Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu 
 865                870                875                880
Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly 
                 885                890                895
Ala Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly 
             900                905                910
Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe 
         915                920                925
Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr 
     930                935                940
Glu Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu 
 945                950                955                960
Glu Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                 965                970



<210> 8645
<211> 487
<212> DNA
<213> Rattus norvegicus
<308> U52950
<400> 8645

gcagagcag  ggagcggcg  gagaggaac  cttctccca  gctttagca  agccggcag  60
atggcgacc  tggtggtgg  agccaccga  ccggagcca  cgggcagca  cggcaaccc  120
gcggcgacc  cctcgccca  cctgtcgca  cgcttccta  acagcaagt  ctacttgct  180
gtggtggtc  gcgagacgg  gaccgaaga  cacctgagg  gtgccatcg  caacatcga  240
ctggggatc  gatcgtggg  gacaaacct  atcgagtgc  acttggacc  agagctcaa  300
cttttcgtg  ctcgacact  cgcgagatt  tctcctgaa  ttccaggac  aaagatcct  360
catcaccga  gtgacgtct  agaaactgt  gttctgatc  acccttcgg  tgaagcagt  420
agcaccgag  tgcgtttgg  gatcactga  gccgcccgc  ataaattgc  ggtgctctc  480
ggacagt  487



<210> 8646
<211> 2459
<212> PRT
<213> Rattus norvegicus
<308> AAB17068
<400> 8646

Met Ala Thr Val Val Val Glu Ala Thr Glu Pro Glu Pro Ser Gly Ser 
  1               5                  10                  15
Ile Gly Asn Pro Ala Ala Thr Thr Ser Pro Ser Leu Ser His Arg Phe 
             20                  25                  30
Leu Asp Ser Lys Phe Tyr Leu Leu Val Val Val Gly Glu Thr Val Thr 
         35                  40                  45
Glu Glu His Leu Arg Arg Ala Ile Gly Asn Ile Glu Leu Gly Ile Arg 
     50                  55                  60
Ser Trp Glu Thr Asn Leu Ile Glu Cys Asn Leu Asp Gln Glu Leu Lys 
 65                  70                  75                  80
Leu Phe Val Ser Arg His Ser Ala Arg Phe Ser Pro Glu Val Pro Gly 
                 85                  90                  95
Gln Lys Ile Leu His His Arg Ser Asp Val Leu Glu Thr Val Val Leu 
             100                105                110
Ile Asn Pro Ser Asp Glu Ala Val Ser Thr Glu Val Arg Leu Met Ile 
         115                120                125
Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln Cys Phe 
     130                135                140
Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser Phe Gln 
 145                150                155                160
Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu Leu Ser 
                 165                170                175
Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys Pro Glu 
             180                185                190
Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu Gln Asp 
         195                200                205
Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu Met Glu 
     210                215                220
Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu Val Pro 
 225                230                235                240
Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Lys 
                 245                250                255
Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly Asp Ser 
             260                265                270
Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly Gly Ser 
         275                280                285
Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp Arg Val 
     290                295                300
Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro Gly Ile 
 305                310                315                320
Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu Ser Gln 
                 325                330                335
Gly Ser Thr Ser Asn Ser Asp Trp Met Lys Asn Leu Ile Ser Pro Asp 
             340                345                350
Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys Asn Pro Glu 
         355                360                365
Pro Asn Ile Lys Met Lys Arg Ser Thr Glu Glu Ala Cys Phe Thr Leu 
     370                375                380
Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu Phe Arg Ser 
 385                390                395                400
Val Gly Asn Ala Ile Glu Pro Val Ile Leu Phe Gln Lys Met Gly Val 
                 405                410                415
Gly Lys Leu Lys Met Tyr Val Leu Asn Pro Val Lys Ser Ser Lys Glu 
             420                425                430
Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys Asp Lys Ala 
         435                440                445
Glu Leu Ile Leu Pro Asn Gly Gln Glu Val Asp Ile Pro Ile Ser Tyr 
     450                455                460
Leu Ala Ser Val Ser Ser Leu Ile Val Trp His Pro Ala Asn Pro Ala 
 465                470                475                480
Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr Gln Tyr Asn 
                 485                490                495
Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe Leu Lys Gln 
             500                505                510
Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Ser Thr Pro Pro 
         515                520                525
Val Lys Gln Val Lys Leu Lys Gln Arg Ala Asp Ser Arg Glu Ser Leu 
     530                535                540
Lys Pro Ala Thr Lys Pro Leu Ser Ser Lys Ser Val Arg Lys Glu Ser 
 545                550                555                560
Lys Glu Glu Ala Pro Glu Ala Thr Lys Ala Ser Gln Val Glu Lys Thr 
                 565                570                575
Pro Lys Val Glu Ser Lys Glu Lys Val Ile Val Lys Lys Asp Lys Pro 
             580                585                590
Gly Lys Val Glu Ser Lys Pro Ser Val Thr Glu Lys Glu Val Pro Ser 
         595                600                605
Lys Glu Glu Gln Ser Pro Val Lys Ala Glu Val Ala Glu Lys Ala Ala 
     610                615                620
Thr Glu Ser Lys Pro Lys Val Thr Lys Asp Lys Val Val Lys Lys Glu 
 625                630                635                640
Ile Lys Thr Lys Pro Glu Glu Lys Lys Glu Glu Lys Pro Lys Lys Glu 
                 645                650                655
Val Ala Lys Lys Glu Asp Lys Thr Pro Leu Lys Lys Asp Glu Lys Pro 
             660                665                670
Lys Lys Glu Glu Ala Lys Lys Glu Ile Lys Lys Glu Ile Lys Lys Glu 
         675                680                685
Glu Lys Lys Glu Leu Lys Lys Glu Val Lys Lys Glu Thr Pro Leu Lys 
     690                695                700
Asp Ala Lys Lys Glu Val Lys Lys Asp Glu Lys Lys Glu Val Lys Lys 
 705                710                715                720
Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys Ile Ser Lys Asp Ile 
                 725                730                735
Lys Lys Ser Thr Pro Leu Ser Asp Thr Lys Lys Pro Ala Ala Leu Lys 
             740                745                750
Pro Lys Val Ala Lys Lys Glu Glu Pro Thr Lys Lys Glu Pro Ile Ala 
         755                760                765
Ala Gly Lys Leu Lys Asp Lys Gly Lys Val Lys Val Ile Lys Lys Glu 
     770                775                780
Gly Lys Thr Thr Glu Ala Ala Ala Thr Ala Val Gly Thr Ala Ala Val 
 785                790                795                800
Ala Ala Ala Ala Gly Val Ala Ala Ser Gly Pro Ala Lys Glu Leu Glu 
                 805                810                815
Ala Glu Arg Ser Leu Met Ser Ser Pro Glu Asp Leu Thr Lys Asp Phe 
             820                825                830
Glu Glu Leu Lys Ala Glu Glu Ile Asp Val Ala Lys Asp Ile Lys Pro 
         835                840                845
Gln Leu Glu Leu Ile Glu Asp Glu Glu Lys Leu Lys Glu Thr Glu Pro 
     850                855                860
Gly Glu Ala Tyr Val Ile Gln Lys Glu Thr Glu Val Ser Lys Gly Ser 
 865                870                875                880
Ala Glu Ser Pro Asp Glu Gly Ile Thr Thr Thr Glu Gly Glu Gly Glu 
                 885                890                895
Cys Glu Gln Thr Pro Glu Glu Leu Glu Pro Val Glu Lys Gln Gly Val 
             900                905                910
Asp Asp Ile Glu Lys Phe Glu Asp Glu Gly Ala Gly Phe Glu Glu Ser 
         915                920                925
Ser Glu Ala Gly Asp Tyr Glu Glu Lys Ala Glu Thr Glu Glu Ala Glu 
     930                935                940
Glu Pro Glu Glu Asp Gly Glu Asp Asn Val Ser Gly Ser Ala Ser Lys 
 945                950                955                960
His Ser Pro Thr Glu Asp Glu Glu Ile Ala Lys Ala Glu Ala Asp Val 
                 965                970                975
His Ile Lys Glu Lys Arg Glu Ser Val Ala Ser Gly Asp Asp Arg Ala 
             980                985                990
Glu Glu Asp Met Asp Glu Ala Leu Glu Lys Gly Glu Ala Glu Gln Ser 
         995                1000                1005
Glu Glu Glu Gly Glu Glu Glu Glu Asp Lys Ala Glu Asp Ala Arg Glu 
     1010                1015                1020
Glu Asp His Glu Pro Asp Lys Thr Glu Ala Glu Asp Tyr Val Met Ala 
 1025                1030                1035                1040
Val Val Asp Lys Ala Ala Glu Ala Gly Val Thr Glu Asp Gln Tyr Asp 
                 1045                1050                1055
Phe Leu Gly Thr Pro Ala Lys Gln Pro Gly Val Gln Ser Pro Ser Arg 
             1060                1065                1070
Glu Pro Ala Ser Ser Ile His Asp Glu Thr Leu Pro Gly Gly Ser Glu 
         1075                1080                1085
Ser Glu Ala Thr Ala Ser Asp Glu Glu Asn Arg Glu Asp Gln Pro Glu 
     1090                1095                1100
Glu Phe Thr Ala Thr Ser Gly Tyr Thr Gln Ser Thr Ile Glu Ile Ser 
 1105                1110                1115                1120
Ser Glu Pro Thr Pro Met Asp Glu Met Ser Thr Pro Arg Asp Val Met 
                 1125                1130                1135
Thr Asp Glu Thr Asn Asn Glu Glu Thr Glu Ser Pro Ser Gln Glu Phe 
             1140                1145                1150
Val Asn Ile Thr Lys Tyr Glu Ser Ser Leu Tyr Ser Gln Glu Tyr Ser 
         1155                1160                1165
Lys Pro Val Val Ala Ser Phe Asn Gly Leu Ser Asp Gly Ser Lys Thr 
     1170                1175                1180
Asp Ala Thr Asp Gly Arg Asp Tyr Asn Ala Ser Ala Ser Thr Ile Ser 
 1185                1190                1195                1200
Pro Pro Ser Ser Met Glu Glu Asp Lys Phe Ser Lys Ser Ala Leu Arg 
                 1205                1210                1215
Asp Ala Tyr Arg Pro Glu Glu Thr Asp Val Lys Thr Gly Ala Glu Leu 
             1220                1225                1230
Asp Ile Lys Asp Val Ser Asp Glu Arg Leu Ser Pro Ala Lys Ser Pro 
         1235                1240                1245
Ser Leu Ser Pro Ser Pro Pro Ser Pro Ile Glu Lys Thr Pro Leu Gly 
     1250                1255                1260
Glu Arg Ser Val Asn Phe Ser Leu Thr Pro Asn Glu Ile Lys Ala Ser 
 1265                1270                1275                1280
Ala Glu Gly Glu Ala Thr Ala Val Val Ser Pro Gly Val Thr Gln Ala 
                 1285                1290                1295
Val Val Glu Glu His Cys Ala Ser Pro Glu Glu Lys Thr Leu Glu Val 
             1300                1305                1310
Val Ser Pro Ser Gln Ser Val Thr Gly Ser Ala Gly His Thr Pro Tyr 
         1315                1320                1325
Tyr Gln Ser Pro Thr Asp Glu Lys Ser Ser His Leu Pro Thr Glu Val 
     1330                1335                1340
Thr Glu Asn Ala Gln Ala Val Pro Val Ser Phe Glu Phe Thr Glu Ala 
 1345                1350                1355                1360
Lys Asp Glu Asn Glu Arg Ser Ser Ile Ser Pro Met Asp Glu Pro Val 
                 1365                1370                1375
Pro Asp Ser Glu Ser Pro Ile Glu Lys Val Leu Ser Pro Leu Arg Ser 
             1380                1385                1390
Pro Pro Leu Ile Gly Ser Glu Ser Ala Tyr Glu Asp Phe Leu Ser Ala 
         1395                1400                1405
Asp Asp Lys Ala Leu Gly Arg Arg Ser Glu Ser Pro Phe Glu Gly Lys 
     1410                1415                1420
Asn Gly Lys Gln Gly Phe Ser Asp Lys Glu Ser Pro Val Ser Asp Leu 
 1425                1430                1435                1440
Thr Ser Asp Leu Tyr Gln Asp Lys Gln Glu Glu Lys Arg Ala Gly Phe 
                 1445                1450                1455
Ile Pro Ile Lys Glu Asp Phe Ser Pro Glu Lys Lys Ala Ser Asp Ala 
             1460                1465                1470
Glu Ile Met Ser Ser Gln Ser Ala Leu Ala Leu Asp Glu Arg Lys Leu 
         1475                1480                1485
Gly Gly Asp Gly Ser Pro Thr Gln Val Asp Val Ser Gln Phe Gly Ser 
     1490                1495                1500
Phe Lys Glu Asp Thr Lys Met Ser Ile Ser Glu Gly Thr Val Ser Asp 
 1505                1510                1515                1520
Lys Ser Ala Thr Pro Val Asp Glu Gly Ala Glu Asp Thr Tyr Ser His 
                 1525                1530                1535
Met Glu Gly Val Ala Ser Val Ser Thr Ala Ser Val Ala Thr Ser Ser 
             1540                1545                1550
Phe Pro Glu Pro Thr Thr Asp Asp Val Ser Pro Ser Leu His Ala Glu 
         1555                1560                1565
Val Gly Ser Pro His Ser Thr Glu Val Asp Asp Ser Leu Ser Val Ser 
     1570                1575                1580
Val Val Gln Thr Pro Thr Thr Phe Gln Glu Thr Glu Met Ser Pro Ser 
 1585                1590                1595                1600
Lys Glu Glu Cys Pro Arg Pro Met Ser Ile Ser Pro Pro Asp Phe Ser 
                 1605                1610                1615
Pro Lys Thr Ala Lys Ser Arg Thr Pro Val Gln Asp His Arg Ser Glu 
             1620                1625                1630
Gln Ser Ser Met Ser Ile Glu Phe Gly Gln Glu Ser Pro Glu His Ser 
         1635                1640                1645
Leu Ala Met Asp Phe Ser Arg Gln Ser Pro Asp His Pro Thr Val Gly 
     1650                1655                1660
Ala Gly Met Leu His Ile Thr Glu Asn Gly Pro Thr Glu Val Asp Tyr 
 1665                1670                1675                1680
Ser Pro Ser Asp Ile Gln Asp Ser Ser Leu Ser His Lys Ile Pro Pro 
                 1685                1690                1695
Thr Glu Glu Pro Ser Tyr Thr Gln Asp Asn Asp Leu Ser Glu Leu Ile 
             1700                1705                1710
Ser Val Ser Gln Val Glu Ala Ser Pro Ser Thr Ser Ser Ala His Thr 
         1715                1720                1725
Pro Ser Gln Ile Ala Ser Pro Leu Gln Glu Asp Thr Leu Ser Asp Val 
     1730                1735                1740
Val Pro Pro Arg Asp Met Ser Leu Tyr Ala Ser Leu Ala Ser Glu Lys 
 1745                1750                1755                1760
Val Gln Ser Leu Glu Gly Glu Lys Leu Ser Pro Lys Ser Asp Ile Ser 
                 1765                1770                1775
Pro Leu Thr Pro Arg Glu Ser Ser Pro Thr Tyr Ser Pro Gly Phe Ser 
             1780                1785                1790
Asp Ser Thr Ser Gly Ala Lys Glu Ser Thr Ala Ala Tyr Gln Thr Ser 
         1795                1800                1805
Ser Ser Pro Pro Ile Asp Ala Ala Ala Ala Glu Pro Tyr Gly Phe Arg 
     1810                1815                1820
Ser Ser Met Leu Phe Asp Thr Met Gln His His Leu Ala Leu Ser Arg 
 1825                1830                1835                1840
Asp Leu Thr Thr Ser Ser Val Glu Lys Asp Asn Gly Gly Lys Thr Pro 
                 1845                1850                1855
Gly Asp Phe Asn Tyr Ala Tyr Gln Lys Pro Glu Ser Thr Thr Glu Ser 
             1860                1865                1870
Pro Asp Glu Glu Asp Tyr Asp Tyr Glu Ser His Glu Lys Thr Ile Gln 
         1875                1880                1885
Ala His Asp Val Gly Gly Tyr Tyr Tyr Glu Lys Thr Glu Arg Thr Ile 
     1890                1895                1900
Lys Ser Pro Cys Asp Ser Gly Tyr Ser Tyr Glu Thr Ile Glu Lys Thr 
 1905                1910                1915                1920
Thr Lys Thr Pro Glu Asp Gly Gly Tyr Ser Cys Glu Ile Thr Glu Lys 
                 1925                1930                1935
Thr Thr Arg Thr Pro Glu Glu Gly Gly Tyr Ser Tyr Glu Ile Ser Glu 
             1940                1945                1950
Lys Thr Thr Arg Thr Pro Glu Val Ser Gly Tyr Thr Tyr Glu Lys Thr 
         1955                1960                1965
Glu Arg Ser Arg Arg Leu Leu Asp Asp Ile Ser Asn Gly Tyr Asp Asp 
     1970                1975                1980
Thr Glu Asp Gly Gly His Thr Leu Gly Asp Cys Ser Tyr Ser Tyr Glu 
 1985                1990                1995                2000
Thr Thr Glu Lys Ile Thr Ser Phe Pro Glu Ser Glu Ser Tyr Ser Tyr 
                 2005                2010                2015
Glu Thr Thr Thr Lys Thr Thr Arg Ser Pro Asp Thr Ser Ala Tyr Cys 
             2020                2025                2030
Tyr Glu Thr Met Glu Lys Ile Thr Lys Thr Pro Gln Ala Ser Thr Tyr 
         2035                2040                2045
Ser Tyr Glu Thr Ser Asp Arg Cys Tyr Thr Pro Glu Arg Lys Ser Pro 
     2050                2055                2060
Ser Glu Ala Arg Gln Asp Val Asp Leu Cys Leu Val Ser Ser Cys Glu 
 2065                2070                2075                2080
Phe Lys His Pro Lys Thr Glu Leu Ser Pro Ser Phe Ile Asn Pro Asn 
                 2085                2090                2095
Pro Leu Glu Trp Phe Ala Gly Glu Glu Pro Thr Glu Glu Ser Glu Arg 
             2100                2105                2110
Pro Leu Thr Gln Ser Gly Gly Ala Pro Pro Pro Ser Gly Gly Lys Gln 
         2115                2120                2125
Gln Gly Arg Gln Cys Asp Glu Thr Pro Pro Thr Ser Val Ser Glu Ser 
     2130                2135                2140
Ala Pro Ser Gln Thr Asp Ser Asp Val Pro Pro Glu Thr Glu Glu Cys 
 2145                2150                2155                2160
Pro Ser Ile Thr Ala Asp Ala Asn Leu Asp Ser Glu Asp Glu Ser Glu 
                 2165                2170                2175
Thr Ile Pro Thr Asp Lys Thr Val Thr Tyr Lys His Met Asp Pro Pro 
             2180                2185                2190
Pro Ala Pro Met Gln Asp Arg Ser Pro Ser Pro Arg His Pro Asp Val 
         2195                2200                2205
Ser Met Val Asp Pro Glu Ala Leu Ala Ile Glu Gln Asn Leu Gly Lys 
     2210                2215                2220
Ala Leu Lys Lys Asp Leu Lys Glu Lys Ala Lys Thr Lys Lys Pro Gly 
 2225                2230                2235                2240
Thr Lys Thr Lys Ser Ser Ser Pro Val Lys Lys Gly Asp Gly Lys Ser 
                 2245                2250                2255
Lys Pro Ser Ala Ala Ser Pro Lys Pro Gly Ala Leu Lys Glu Ser Ser 
             2260                2265                2270
Asp Lys Val Ser Arg Val Ala Ser Pro Lys Lys Lys Glu Ser Val Glu 
         2275                2280                2285
Lys Ala Met Lys Thr Thr Thr Thr Pro Glu Val Lys Ala Thr Arg Gly 
     2290                2295                2300
Glu Glu Lys Asp Lys Glu Thr Lys Asn Ala Ala Asn Ala Ser Ala Ser 
 2305                2310                2315                2320
Lys Ser Val Lys Thr Ala Thr Ala Gly Pro Gly Thr Thr Lys Thr Ala 
                 2325                2330                2335
Lys Ser Ser Thr Val Pro Pro Gly Leu Pro Val Tyr Leu Asp Leu Cys 
             2340                2345                2350
Tyr Ile Pro Asn His Ser Asn Ser Lys Asn Val Asp Val Glu Phe Phe 
         2355                2360                2365
Lys Arg Val Arg Ser Ser Tyr Tyr Val Val Ser Gly Asn Asp Pro Ala 
     2370                2375                2380
Ala Glu Glu Pro Ser Arg Ala Val Leu Asp Ala Leu Leu Glu Gly Lys 
 2385                2390                2395                2400
Ala Gln Trp Gly Ser Asn Met Gln Val Thr Leu Ile Pro Thr His Asp 
                 2405                2410                2415
Ser Glu Val Met Arg Glu Trp Tyr Gln Glu Thr His Glu Lys Gln Gln 
             2420                2425                2430
Asp Leu Asn Ile Met Val Leu Ala Ser Ser Ser Thr Val Val Met Gln 
         2435                2440                2445
Asp Glu Ser Phe Pro Ala Cys Lys Ile Glu Leu 
     2450                2455



<210> 8647
<211> 9416
<212> DNA
<213> Homo sapiens
<308> NM_005909
<400> 8647

aagcgcgcc  cctccccgc  ctctctcac  ccccgctcc  ctccgccgc  cactctcgc  60
gcgctggga  agggcggag  gggaggcgg  gcgcggcgc  agaggaggg  ggacgcagg  120
ggcggagcg  agacagtac  ttcggagat  atcctttct  ctgccgcag  ggagaggag  180
ggccggagc  agacacttc  ccgaggcac  gcagccggc  ggatggcga  cgtggtggt  240
gaagccacc  agccggagc  gtccggcag  atcgccaac  cggcggcgt  cacctcgcc  300
agcctgtcg  accgcttcc  tgacagcaa  ttctacttg  tggtggtcg  cggcgagat  360
gtgaccgag  agcacctgc  gcgtgccat  ggcaacatc  agctcggaa  ccgatcatg  420
gacacaaac  tgattgaat  caacttgga  caagaactc  aactttttg  atctcgaca  480
tctgcaaga  tctctcctg  agtcccagg  caaaagatc  ttcatcacc  aagtgacgt  540
ttagaaaca  tggtcctga  caacccttc  gatgaagca  tcagcaccg  ggtgcgctt  600
atgatcact  atgctgccc  acacaagct  ctcgtgctg  ccgggcagt  ctttgaaaa  660
accggagag  tcattctcc  gtccggctc  ttctccttc  agaacttca  agagatttt  720
accgatcaa  agatcgggg  gttactaag  accacccat  ctgccaaca  agccagctt  780
accctgttc  gtcctgaag  aggggactg  aagaactcc  atcttgaca  acacaatct  840
caagacttc  tcaatatta  actcaattc  gcttctatc  tgccagaaa  ggaaggact  900
tctgagttt  ccgagtatc  ctcagaatc  gtggaagtc  catctccct  tgacatctt  960
gaacctccc  catcgggtg  atttctgaa  ctctccaag  cctgctgtt  tatttttcc  1020
ggagggagg  gcgattctg  cttgtttgc  gtgaatggt  tcaatatgc  catcaatgg  1080
ggatcagag  gaaaatcct  cttctggaa  ctcatccga  acttagacc  agtggactc  1140
atcctgctc  cccacattg  ggatgacaa  ttgcctgga  taaacagca  gttacagcg  1200
aaaattgca  agctcgagg  agaacagtc  cagggctcc  ccacaaata  tgactggat  1260
aaaaacctc  tctcccctg  cttaggagt  gtatttctc  atgtacctg  aaatctcaa  1320
aatccagag  caaacatca  gatgaagag  agcatagaa  aagcctgct  cactctcca  1380
tacctaaac  aattgtcca  gaaaccaga  cctctgttt  gaagtgtag  caatactat  1440
gatcctgtc  ttcttttcc  aaaaatggg  gtaggtaaa  ttgagatgt  tgtgcttaa  1500
ccagtcaag  gcagcaagg  aatgcagta  tttatgcag  agtggactg  taccaacaa  1560
gacaaggct  aattcattc  gcctaatgg  caagaagta  atctcccga  ttcctactt  1620
acttcagtc  catctttga  tgtgtggca  ccagcaaac  ctgcggaga  aatcatccg  1680
gtcctgttt  ctgggaaca  cacccagta  aacatcctg  aagggttgg  aaagctcaa  1740
catctagac  ttctgaagc  gccactggc  acccaaaag  atctcactg  ccaggtgcc  1800
actcctgtg  tgaaacaaa  aaaactgaa  cagagggct  atagccgag  aagtctgaa  1860
ccagccgca  aaccacttc  tagcaaatc  gtgcgcaag  agtcaaaag  agaaacccc  1920
gaggtcaca  aagtgaatc  cgtggaaaa  ccacccaaa  ttgaaagca  agaaaaggt  1980
atggtgaaa  aagacaagc  agtaaaaac  gagaccaaa  cttcagtga  tgaaaagga  2040
gttcccagc  aagaagagc  atctccagt  aaagccgag  tggctgaga  gcaagccac  2100
gatgtcaaa  ccaaagctg  caaggagaa  acggtgaaa  aggaaacaa  ggtaaagcc  2160
gaagacaag  aagaggaga  agaaaagcc  aagaaagaa  tggctaaaa  ggaggacaa  2220
acacctatc  agaaggagg  aaaaccaaa  aaggaagag  tgaaaaaag  agtcaaaaa  2280
gagatcaag  aagaagaga  aaaagaacc  aagaaagag  ttaagaaag  aacaccgcc  2340
aaggaagtc  agaaggaag  taagaagga  gagaagaag  aagtgaaaa  ggaagaaaa  2400
gaacccaaa  aagaaatta  gaagctccc  aaagacgca  agaaatcat  tactcctct  2460
tctgaagca  aaaaaccag  tgctttaaa  ccaaaagta  ccaagaagg  agagtctgt  2520
aagaaagat  ctgttgctg  cggaaagcc  aaggagaag  ggaaaataa  agtcattaa  2580
aaggaaggc  aggccgcag  ggctgtcgc  gcagctgtc  gcactggag  caccacagc  2640
gctgtcatg  cggcagctg  aatagcagc  attggccct  ccaaagaac  cgaagctga  2700
aggtccctt  tgtcatctc  tgaggatct  accaaggac  ttgaagagt  aaaggctga  2760
gaggtcgat  taacaaagg  catcaagcc  cagctggag  taatcgaag  cgaagagaa  2820
ctgaaggaa  ctgagccag  cgaagccta  gtcatccag  aggagagag  agtcaccaa  2880
ggtcctgcc  agtcccctg  tgagggaat  actaccact  aaggggagg  cgaatgtga  2940
cagacacct  aggagctgg  gcccgtcga  aagcaggga  tagacgaca  tgaaaaatt  3000
gaagatgaa  gagccggtt  tgaagaatc  tcagagact  gagactatg  agagaaggc  3060
gaaactgag  aggctgagg  gccagaaga  gatggggag  aacacgtat  tgtgagcgc  3120
tccaagcac  gccccactg  ggatgagga  agtgccaag  cggaggctg  tgcatacat  3180
agggagaag  gggagtctg  ggccagtgg  gatgaccga  ccgaagaag  catggatga  3240
gccattgag  aaggagagg  tgaacaatc  gaagaggag  ctgatgagg  ggacaaagc  3300
gaagatgcc  gagaggagg  atatgagcc  gaaaaaatg  aagctgaag  ctatgtgat  3360
gctgtggtc  acaaggctg  agaggctgg  ggtgccgag  agcagtatg  attcctcac  3420
acaccaacc  agcaactag  agcccagtc  cctggccga  aacctgcat  ttcaattca  3480
gatgagact  tacctggag  ctcagagag  gaggccacc  cttctgatg  ggagaatcg  3540
gaagaccag  ctgaggaat  cactgccac  tctggctac  ctcagtcta  tattgagat  3600
tccagtgag  ccaccccca  ggatgagat  tctacccct  gagacgtga  gagtgatga  3660
accaacaat  aagagacgg  gtccccttc  caggaattc  taaatatca  caaatatga  3720
tcttcattg  attctcagg  atactctaa  cctgctgat  ttacaccgc  caacggatt  3780
tctgaagga  caaaaacag  tgccactga  ggcaaggat  acaatgctt  agcctctac  3840
atatcacca  cctcttcca  ggaggaaga  aaattcagc  gatctgctt  acgtgatgc  3900
tactgctct  aagtgaaag  cagcaccac  ttggacatc  aagatagca  ctcagctgt  3960
tcaagtgaa  aggtcagcc  atcgaagag  ccgtccctg  gtccatctc  accatcacc  4020
ttagaaaag  cccccctgg  tgaacgtag  gtgaacttc  ctctgacgc  caatgagat  4080
aaagtctct  cagaggcag  agtagcccc  gtgtctcct  aggtgaccc  agaagtagt  4140
gaagaacat  gtgctagtc  tgaggacaa  actctggaa  tggtgtcac  atctcagtc  4200
gtgactggc  gtgctggtc  cacacctta  tatcaatct  ctactgacg  gaaatccag  4260
catctccct  cagaagtca  tgaaaaacc  ccagcagtt  cagtgagtt  tgaattcag  4320
gatgccaaa  atgagaatg  aagggcttc  gtaagcccc  tggatgagc  cgtgcctga  4380
tcagagtct  ctattgaaa  agttttgtc  cctttacgc  gcccgcccc  cattggatc  4440
gagtctgct  atgaaagtt  tctaagtgc  gatgacaag  cttctggca  aggtgccga  4500
agtcctttt  aagaaaaga  tggaaaaca  ggctctcca  accaagtaa  tccagtttc  4560
gaaatgact  ctactagtc  ttaccaaga  aaacaggaa  ggaaaagca  agactttgc  4620
ccaataaaa  aagactttg  ccaagaaaa  aaaactgat  atgttgaag  catgagttc  4680
caaccagca  tggctctgg  tgaaaggaa  ttaggagat  tttctccca  acaaataga  4740
gtcagtcag  ttggatctt  taaagaaga  actaagatg  ccatttctg  aggtactgt  4800
tcagacaag  cagctactc  tgttgatga  ggcgtagca  aagacacgt  ctctcatat  4860
gagggtgtg  cctcagtgt  cacagcctc  gtggctacg  gctcatttc  agagccaac  4920
acagatgat  tgtctccat  tctgcatgc  gaggttggc  ccccacatt  cacagaagt  4980
gatgactcc  tttcagtgt  tgttgtgca  acacctacc  cattccagg  aacagaaat  5040
tctccatct  aagaagaat  cccaagacc  atgtcaatt  ctccaccag  tttctcccc  5100
aaaactgca  agtccagga  acccgttca  gatcacaga  ctgaacagt  ctcaatgtc  5160
attgaattt  gccaagaat  tcctgagca  tcccttgct  tggacttca  tcgacagtc  5220
ccagatcac  ctacagtgg  tgcaggcgt  cttcacatc  ctgaaaatg  gccaactga  5280
gtggactac  gtccttctg  catgcagga  tccagttta  cacataaga  accacctat  5340
gaggagccg  cctacaccc  agataatga  ctttctgag  tcatctcag  atctcaggt  5400
gaggcctcc  cgtccacct  ttctgctca  accccttct  agatcgctt  tcctctcca  5460
gaagatact  tatccgatg  tgctcctcc  agagatatg  ccttatatg  ctcactcac  5520
tctgaaaaa  tgcaaagtc  ggaaggaga  aagctctct  caaaatctg  tatctctcc  5580
ctcacccca  gagagtcct  tcctttata  tcacctact  tttcagatt  tacctctgc  5640
gtcaaagag  aaacagcaa  ttgccacag  tcctcttct  caccaatag  tgcagcatc  5700
gcagagccc  atggcttcc  tgcctcagt  ttattcgat  caatgcaac  ccatctagc  5760
ttgaataga  atttgtcca  acctggcct  gagaaggac  gtggaggga  gacacctgg  5820
gactttagc  atgcctatc  aaagcctga  gaaacaacc  ggtccccag  tgaagaaga  5880
tatgactat  agtcttatg  gaagaccac  cggacctca  atgtgggtg  ctattacta  5940
gagaagata  agagaacca  aaaatctcc  agtgacagt  gctactcct  tgagaccat  6000
gggaaaact  ccaagaccc  tgaagatgg  gactattcc  atgaaatta  tgagaagac  6060
acacggacc  ctgaagagg  tgggtactc  tatgacata  gtgaaaaga  caccagccc  6120
cccgaagtg  gtggttaca  ctatgaaaa  actgagagg  ctagaaggc  tctggatga  6180
atcagcaat  gctatgatg  ctctgagga  ggtggccac  cacttgggg  ccccagcta  6240
tcttatgaa  ccactgaga  aattaccag  ttccctgag  ctgaaggtt  ttcctatga  6300
acatctaca  agacaacac  aacccctga  acttccaca  actgttacg  gactgcaga  6360
aaaatcact  gaacccctc  ggcatccac  tattcctac  agacttcag  cctatgcta  6420
actgcagaa  agaagtccc  ctcagaagc  cgtcaggat  tcgatttat  cctcgtgtc  6480
tcttgtgaa  acaagcacc  caagacaga  ctttcaccc  ctttcatta  tcccaatcc  6540
cttgagtgg  ttgccagtg  agaacccac  gaagaatct  aaaagcccc  cactcaatc  6600
gggggagcc  caccgcctc  aggaggaaa  caacagggc  gacagtgtg  tgaaacccc  6660
cccacctca  tcagcgagt  agccccatc  cagaccgac  ctgatgttc  cccggagac  6720
gaagagtgc  cctccatca  ggccgatgc  aatatcgac  ctgaagacg  gtcggaaac  6780
atccccaca  acaaaactg  cacgtacaa  cacatggac  cacctccag  tcccgtgca  6840
gaccgcagc  cttcgccac  ccaccctga  gtgtccatg  tggacccag  ggccttggc  6900
attgagcag  acctgggca  agctctaaa  aaagatctg  aagagaaga  caaaaccaa  6960
aagccaggt  caaagacca  gtcatcttc  cctgtcaaa  agagtgatg  gaagtctaa  7020
cccttggca  cttcaccaa  accagcggg  ttgaaagaa  cctcggata  agtgtccag  7080
gtggcttct  ctaagaaga  agaatctgt  gaaaaggca  caaaaccca  caccactcc  7140
gaggtcaaa  ctgcacgtg  ggaagagaa  gacaaggag  ccaagaatg  tgccaatgc  7200
tctgcatcc  agtcggcca  gaccgccac  gcaggacca  gaactacca  gacgaccaa  7260
tcatctgct  tgcccccag  cctccctgt  tatttggac  tgtgctaca  tcctaacca  7320
agcaatagt  agaatgttg  tgtggaatt  ttcaagaga  tgcggtctt  ctactacgt  7380
gtgagtggg  atgaccctg  tgctgagga  cccagccgg  ctgtcctgg  cgctttgtt  7440
gaaggaaag  ctcagtggg  cagcaacat  caggtgaca  tgatcccaa  tcatgactc  7500
gaagtgatg  gggaatggt  ccaggagac  catgagaaa  agcaagatc  caacatcat  7560
gttttagca  gcagcagca  agtggttat  caagatgaa  ccttccctg  atgcaagat  7620
gaactgtaa  aaccaaggc  agccacacc  caggatctg  actttgttt  cagaaattc  7680
tcaatttga  atcaccttt  ctaaaaagt  aattcatct  gttaagtcg  tgaacaatt  7740
cctgccaaa  gctatactg  gtcatggtg  tgcaagtca  taaatttct  agtttttgc  7800
gattgctaa  ggaaataac  gtatttcca  aatagggtt  aaattcctg  aaaattacc  7860
accccagtt  atctctgct  aacatttgg  aaccatgca  tagccaacc  aactgactt  7920
tgctaggta  aggcatttg  cttagagag  gagagagcg  gggagagag  gagagagag  7980
gagagcaca  agataacgc  ggagagaga  agagaaaga  tgagaaaga  aaggaatgc  8040
agagaagga  atgtaatga  agagagttc  ggtgagata  ccagagaga  aaagagaga  8100
cagggtggg  taaggagga  aaaataaac  aacaattag  tctgcattt  ctcaggcag  8160
aggcattct  tagtctaca  aggcaaagt  ttccatttt  gtcagtctg  gtcatcaaa  8220
agagtctta  ttttctaaa  caagttggc  agaagaaag  aaaaagaac  acacttgtt  8280
tgagggcat  tgatatttt  acatcttaa  taagctcct  cagtttgaa  gctgcacac  8340
gacataatg  agtgagtgt  gactggcca  gcaagtggt  tgggcccca  tcagaactc  8400
cagactcta  acacacaag  agattgatc  aaggcatgc  cccagcatt  gtccaccca  8460
ttagtccac  ctgagtcga  taacctgca  gcagcaaca  ccaagtcca  cccaattaa  8520
tgaagcaaa  accaaagca  ttgggagta  atatggtag  caatttgcc  taggaagtg  8580
cttgaatgt  caaagatac  tgatgcact  attttttaa  gtgagacag  aagtttata  8640
aacatccat  taggattat  gatacttaa  ggaacacgt  ggtgagcgt  tgtgggggt  8700
ctagaagct  atctgattg  tccaacagt  tgatgctga  tcatgcgtg  tgaatccca  8760
ttcagtgca  ctgtggcct  tcagtcaaa  aagttgtgc  tttcacagc  tctttacta  8820
tgcaagttc  agactgaaa  ggcttctat  atcagaact  ggaaaacag  gaatcttat  8880
gtggaagag  ttctcagca  gtgtacagt  tttaccttc  tttgtctta  attggcttt  8940
taaattttc  attaatttc  acataatta  gggaacaag  gtacagaag  atttttttt  9000
taagatatg  gagaacttt  catagatga  ctttttaac  aatgttttc  tttacagga  9060
attgcaaag  aaattctca  gtgatagtc  tttttttta  gtgtttcgt  agacaaaaa  9120
tgaataatg  tttttgaag  tctggcaag  ttgaagtct  atattgcag  aatgatatt  9180
attaaaaac  cataactac  aggaataat  atacctccc  ccccttgat  cccataaca  9240
aaaagtgct  cttgagagt  ggggagaat  gcatggtag  ctacttttc  gggccttga  9300
aagtacatc  cccagtggt  tcctacata  ttctttcaa  atcttcaac  atgaggtaa  9360
agagccaag  tcaaagaac  ctagcacaa  tttgctttg  gattttctt  tctgga  9416



<210> 8648
<211> 2468
<212> PRT
<213> Homo sapiens
<308> NP_005900
<400> 8648

Met Ala Thr Val Val Val Glu Ala Thr Glu Pro Glu Pro Ser Gly Ser 
  1               5                  10                  15
Ile Ala Asn Pro Ala Ala Ser Thr Ser Pro Ser Leu Ser His Arg Phe 
             20                  25                  30
Leu Asp Ser Lys Phe Tyr Leu Leu Val Val Val Gly Glu Ile Val Thr 
         35                  40                  45
Glu Glu His Leu Arg Arg Ala Ile Gly Asn Ile Glu Leu Gly Ile Arg 
     50                  55                  60
Ser Trp Asp Thr Asn Leu Ile Glu Cys Asn Leu Asp Gln Glu Leu Lys 
 65                  70                  75                  80
Leu Phe Val Ser Arg His Ser Ala Arg Phe Ser Pro Glu Val Pro Gly 
                 85                  90                  95
Gln Lys Ile Leu His His Arg Ser Asp Val Leu Glu Thr Val Val Leu 
             100                105                110
Ile Asn Pro Ser Asp Glu Ala Val Ser Thr Glu Val Arg Leu Met Ile 
         115                120                125
Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln Cys Phe 
     130                135                140
Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser Phe Gln 
 145                150                155                160
Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu Leu Ser 
                 165                170                175
Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys Pro Glu 
             180                185                190
Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu Gln Asp 
         195                200                205
Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu Met Glu 
     210                215                220
Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu Val Pro 
 225                230                235                240
Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Lys 
                 245                250                255
Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly Asp Ser 
             260                265                270
Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly Gly Ser 
         275                280                285
Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp Arg Val 
     290                295                300
Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro Gly Ile 
 305                310                315                320
Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu Gln Ser 
                 325                330                335
Gln Gly Ser Thr Thr Asn Ser Asp Trp Met Lys Asn Leu Ile Ser Pro 
             340                345                350
Asp Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys Asn Pro 
         355                360                365
Glu Pro Asn Ile Lys Met Lys Arg Ser Ile Glu Glu Ala Cys Phe Thr 
     370                375                380
Leu Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu Phe Arg 
 385                390                395                400
Ser Val Gly Asn Thr Ile Asp Pro Val Ile Leu Phe Gln Lys Met Gly 
                 405                410                415
Val Gly Lys Leu Glu Met Tyr Val Leu Asn Pro Val Lys Ser Ser Lys 
             420                425                430
Glu Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys Asp Lys 
         435                440                445
Ala Glu Phe Ile Leu Pro Asn Gly Gln Glu Val Asp Leu Pro Ile Ser 
     450                455                460
Tyr Leu Thr Ser Val Ser Ser Leu Ile Val Trp His Pro Ala Asn Pro 
 465                470                475                480
Ala Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr Gln Tyr 
                 485                490                495
Asn Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe Leu Lys 
             500                505                510
Gln Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Pro Thr Pro 
         515                520                525
Val Val Lys Gln Thr Lys Leu Lys Gln Arg Ala Asp Ser Arg Glu Ser 
     530                535                540
Leu Lys Pro Ala Ala Lys Pro Leu Pro Ser Lys Ser Val Arg Lys Glu 
 545                550                555                560
Ser Lys Glu Glu Thr Pro Glu Val Thr Lys Val Asn His Val Glu Lys 
                 565                570                575
Pro Pro Lys Val Glu Ser Lys Glu Lys Val Met Val Lys Lys Asp Lys 
             580                585                590
Pro Val Lys Thr Glu Thr Lys Pro Ser Val Thr Glu Lys Glu Val Pro 
         595                600                605
Ser Lys Glu Glu Pro Ser Pro Val Lys Ala Glu Val Ala Glu Lys Gln 
     610                615                620
Ala Thr Asp Val Lys Pro Lys Ala Ala Lys Glu Lys Thr Val Lys Lys 
 625                630                635                640
Glu Thr Lys Val Lys Pro Glu Asp Lys Lys Glu Glu Lys Glu Lys Pro 
                 645                650                655
Lys Lys Glu Val Ala Lys Lys Glu Asp Lys Thr Pro Ile Lys Lys Glu 
             660                665                670
Glu Lys Pro Lys Lys Glu Glu Val Lys Lys Glu Val Lys Lys Glu Ile 
         675                680                685
Lys Lys Glu Glu Lys Lys Glu Pro Lys Lys Glu Val Lys Lys Glu Thr 
     690                695                700
Pro Pro Lys Glu Val Lys Lys Glu Val Lys Lys Glu Glu Lys Lys Glu 
 705                710                715                720
Val Lys Lys Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys Leu Pro 
                 725                730                735
Lys Asp Ala Lys Lys Ser Ser Thr Pro Leu Ser Glu Ala Lys Lys Pro 
             740                745                750
Ala Ala Leu Lys Pro Lys Val Pro Lys Lys Glu Glu Ser Val Lys Lys 
         755                760                765
Asp Ser Val Ala Ala Gly Lys Pro Lys Glu Lys Gly Lys Ile Lys Val 
     770                775                780
Ile Lys Lys Glu Gly Lys Ala Ala Glu Ala Val Ala Ala Ala Val Gly 
 785                790                795                800
Thr Gly Ala Thr Thr Ala Ala Val Met Ala Ala Ala Gly Ile Ala Ala 
                 805                810                815
Ile Gly Pro Ala Lys Glu Leu Glu Ala Glu Arg Ser Leu Met Ser Ser 
             820                825                830
Pro Glu Asp Leu Thr Lys Asp Phe Glu Glu Leu Lys Ala Glu Glu Val 
         835                840                845
Asp Val Thr Lys Asp Ile Lys Pro Gln Leu Glu Leu Ile Glu Asp Glu 
     850                855                860
Glu Lys Leu Lys Glu Thr Glu Pro Val Glu Ala Tyr Val Ile Gln Lys 
 865                870                875                880
Glu Arg Glu Val Thr Lys Gly Pro Ala Glu Ser Pro Asp Glu Gly Ile 
                 885                890                895
Thr Thr Thr Glu Gly Glu Gly Glu Cys Glu Gln Thr Pro Glu Glu Leu 
             900                905                910
Glu Pro Val Glu Lys Gln Gly Val Asp Asp Ile Glu Lys Phe Glu Asp 
         915                920                925
Glu Gly Ala Gly Phe Glu Glu Ser Ser Glu Thr Gly Asp Tyr Glu Glu 
     930                935                940
Lys Ala Glu Thr Glu Glu Ala Glu Glu Pro Glu Glu Asp Gly Glu Glu 
 945                950                955                960
His Val Cys Val Ser Ala Ser Lys His Ser Pro Thr Glu Asp Glu Glu 
                 965                970                975
Ser Ala Lys Ala Glu Ala Asp Ala Tyr Ile Arg Glu Lys Arg Glu Ser 
             980                985                990
Val Ala Ser Gly Asp Asp Arg Ala Glu Glu Asp Met Asp Glu Ala Ile 
         995                1000                1005
Glu Lys Gly Glu Ala Glu Gln Ser Glu Glu Glu Ala Asp Glu Glu Asp 
     1010                1015                1020
Lys Ala Glu Asp Ala Arg Glu Glu Glu Tyr Glu Pro Glu Lys Met Glu 
 1025                1030                1035                1040
Ala Glu Asp Tyr Val Met Ala Val Val Asp Lys Ala Ala Glu Ala Gly 
                 1045                1050                1055
Gly Ala Glu Glu Gln Tyr Gly Phe Leu Thr Thr Pro Thr Lys Gln Leu 
             1060                1065                1070
Gly Ala Gln Ser Pro Gly Arg Glu Pro Ala Ser Ser Ile His Asp Glu 
         1075                1080                1085
Thr Leu Pro Gly Gly Ser Glu Ser Glu Ala Thr Ala Ser Asp Glu Glu 
     1090                1095                1100
Asn Arg Glu Asp Gln Pro Glu Glu Phe Thr Ala Thr Ser Gly Tyr Thr 
 1105                1110                1115                1120
Gln Ser Thr Ile Glu Ile Ser Ser Glu Pro Thr Pro Met Asp Glu Met 
                 1125                1130                1135
Ser Thr Pro Arg Asp Val Met Ser Asp Glu Thr Asn Asn Glu Glu Thr 
             1140                1145                1150
Glu Ser Pro Ser Gln Glu Phe Val Asn Ile Thr Lys Tyr Glu Ser Ser 
         1155                1160                1165
Leu Tyr Ser Gln Glu Tyr Ser Lys Pro Ala Asp Val Thr Pro Leu Asn 
     1170                1175                1180
Gly Phe Ser Glu Gly Ser Lys Thr Asp Ala Thr Asp Gly Lys Asp Tyr 
 1185                1190                1195                1200
Asn Ala Ser Ala Ser Thr Ile Ser Pro Pro Ser Ser Met Glu Glu Asp 
                 1205                1210                1215
Lys Phe Ser Arg Ser Ala Leu Arg Asp Ala Tyr Cys Ser Glu Val Lys 
             1220                1225                1230
Ala Ser Thr Thr Leu Asp Ile Lys Asp Ser Ile Ser Ala Val Ser Ser 
         1235                1240                1245
Glu Lys Val Ser Pro Ser Lys Ser Pro Ser Leu Ser Pro Ser Pro Pro 
     1250                1255                1260
Ser Pro Leu Glu Lys Thr Pro Leu Gly Glu Arg Ser Val Asn Phe Ser 
 1265                1270                1275                1280
Leu Thr Pro Asn Glu Ile Lys Val Ser Ala Glu Ala Glu Val Ala Pro 
                 1285                1290                1295
Val Ser Pro Glu Val Thr Gln Glu Val Val Glu Glu His Cys Ala Ser 
             1300                1305                1310
Pro Glu Asp Lys Thr Leu Glu Val Val Ser Pro Ser Gln Ser Val Thr 
         1315                1320                1325
Gly Ser Ala Gly His Thr Pro Tyr Tyr Gln Ser Pro Thr Asp Glu Lys 
     1330                1335                1340
Ser Ser His Leu Pro Thr Glu Val Ile Glu Lys Pro Pro Ala Val Pro 
 1345                1350                1355                1360
Val Ser Phe Glu Phe Ser Asp Ala Lys Asp Glu Asn Glu Arg Ala Ser 
                 1365                1370                1375
Val Ser Pro Met Asp Glu Pro Val Pro Asp Ser Glu Ser Pro Ile Glu 
             1380                1385                1390
Lys Val Leu Ser Pro Leu Arg Ser Pro Pro Leu Ile Gly Ser Glu Ser 
         1395                1400                1405
Ala Tyr Glu Ser Phe Leu Ser Ala Asp Asp Lys Ala Ser Gly Arg Gly 
     1410                1415                1420
Ala Glu Ser Pro Phe Glu Glu Lys Ser Gly Lys Gln Gly Ser Pro Asp 
 1425                1430                1435                1440
Gln Val Ser Pro Val Ser Glu Met Thr Ser Thr Ser Leu Tyr Gln Asp 
                 1445                1450                1455
Lys Gln Glu Gly Lys Ser Thr Asp Phe Ala Pro Ile Lys Glu Asp Phe 
             1460                1465                1470
Gly Gln Glu Lys Lys Thr Asp Asp Val Glu Ala Met Ser Ser Gln Pro 
         1475                1480                1485
Ala Leu Ala Leu Asp Glu Arg Lys Leu Gly Asp Val Ser Pro Thr Gln 
     1490                1495                1500
Ile Asp Val Ser Gln Phe Gly Ser Phe Lys Glu Asp Thr Lys Met Ser 
 1505                1510                1515                1520
Ile Ser Glu Gly Thr Val Ser Asp Lys Ser Ala Thr Pro Val Asp Glu 
                 1525                1530                1535
Gly Val Ala Glu Asp Thr Tyr Ser His Met Glu Gly Val Ala Ser Val 
             1540                1545                1550
Ser Thr Ala Ser Val Ala Thr Ser Ser Phe Pro Glu Pro Thr Thr Asp 
         1555                1560                1565
Asp Val Ser Pro Ser Leu His Ala Glu Val Gly Ser Pro His Ser Thr 
     1570                1575                1580
Glu Val Asp Asp Ser Leu Ser Val Ser Val Val Gln Thr Pro Thr Thr 
 1585                1590                1595                1600
Phe Gln Glu Thr Glu Met Ser Pro Ser Lys Glu Glu Cys Pro Arg Pro 
                 1605                1610                1615
Met Ser Ile Ser Pro Pro Asp Phe Ser Pro Lys Thr Ala Lys Ser Arg 
             1620                1625                1630
Thr Pro Val Gln Asp His Arg Ser Glu Gln Ser Ser Met Ser Ile Glu 
         1635                1640                1645
Phe Gly Gln Glu Ser Pro Glu Gln Ser Leu Ala Met Asp Phe Ser Arg 
     1650                1655                1660
Gln Ser Pro Asp His Pro Thr Val Gly Ala Gly Val Leu His Ile Thr 
 1665                1670                1675                1680
Glu Asn Gly Pro Thr Glu Val Asp Tyr Ser Pro Ser Asp Met Gln Asp 
                 1685                1690                1695
Ser Ser Leu Ser His Lys Ile Pro Pro Met Glu Glu Pro Ser Tyr Thr 
             1700                1705                1710
Gln Asp Asn Asp Leu Ser Glu Leu Ile Ser Val Ser Gln Val Glu Ala 
         1715                1720                1725
Ser Pro Ser Thr Ser Ser Ala His Thr Pro Ser Gln Ile Ala Ser Pro 
     1730                1735                1740
Leu Gln Glu Asp Thr Leu Ser Asp Val Ala Pro Pro Arg Asp Met Ser 
 1745                1750                1755                1760
Leu Tyr Ala Ser Leu Thr Ser Glu Lys Val Gln Ser Leu Glu Gly Glu 
                 1765                1770                1775
Lys Leu Ser Pro Lys Ser Asp Ile Ser Pro Leu Thr Pro Arg Glu Ser 
             1780                1785                1790
Ser Pro Leu Tyr Ser Pro Thr Phe Ser Asp Ser Thr Ser Ala Val Lys 
         1795                1800                1805
Glu Lys Thr Ala Thr Cys His Ser Ser Ser Ser Pro Pro Ile Asp Ala 
     1810                1815                1820
Ala Ser Ala Glu Pro Tyr Gly Phe Arg Ala Ser Val Leu Phe Asp Thr 
 1825                1830                1835                1840
Met Gln His His Leu Ala Leu Asn Arg Asp Leu Ser Thr Pro Gly Leu 
                 1845                1850                1855
Glu Lys Asp Ser Gly Gly Lys Thr Pro Gly Asp Phe Ser Tyr Ala Tyr 
             1860                1865                1870
Gln Lys Pro Glu Glu Thr Thr Arg Ser Pro Asp Glu Glu Asp Tyr Asp 
         1875                1880                1885
Tyr Glu Ser Tyr Glu Lys Thr Thr Arg Thr Ser Asp Val Gly Gly Tyr 
     1890                1895                1900
Tyr Tyr Glu Lys Ile Glu Arg Thr Thr Lys Ser Pro Ser Asp Ser Gly 
 1905                1910                1915                1920
Tyr Ser Tyr Glu Thr Ile Gly Lys Thr Thr Lys Thr Pro Glu Asp Gly 
                 1925                1930                1935
Asp Tyr Ser Tyr Glu Ile Ile Glu Lys Thr Thr Arg Thr Pro Glu Glu 
             1940                1945                1950
Gly Gly Tyr Ser Tyr Asp Ile Ser Glu Lys Thr Thr Ser Pro Pro Glu 
         1955                1960                1965
Val Ser Gly Tyr Ser Tyr Glu Lys Thr Glu Arg Ser Arg Arg Leu Leu 
     1970                1975                1980
Asp Asp Ile Ser Asn Gly Tyr Asp Asp Ser Glu Asp Gly Gly His Thr 
 1985                1990                1995                2000
Leu Gly Asp Pro Ser Tyr Ser Tyr Glu Thr Thr Glu Lys Ile Thr Ser 
                 2005                2010                2015
Phe Pro Glu Ser Glu Gly Tyr Ser Tyr Glu Thr Ser Thr Lys Thr Thr 
             2020                2025                2030
Arg Thr Pro Asp Thr Ser Thr Tyr Cys Tyr Glu Thr Ala Glu Lys Ile 
         2035                2040                2045
Thr Arg Thr Pro Gln Ala Ser Thr Tyr Ser Tyr Glu Thr Ser Asp Leu 
     2050                2055                2060
Cys Tyr Thr Ala Glu Lys Lys Ser Pro Ser Glu Ala Arg Gln Asp Val 
 2065                2070                2075                2080
Asp Leu Cys Leu Val Ser Ser Cys Glu Tyr Lys His Pro Lys Thr Glu 
                 2085                2090                2095
Leu Ser Pro Ser Phe Ile Asn Pro Asn Pro Leu Glu Trp Phe Ala Ser 
             2100                2105                2110
Glu Glu Pro Thr Glu Glu Ser Glu Lys Pro Leu Thr Gln Ser Gly Gly 
         2115                2120                2125
Ala Pro Pro Pro Pro Gly Gly Lys Gln Gln Gly Arg Gln Cys Asp Glu 
     2130                2135                2140
Thr Pro Pro Thr Ser Val Ser Glu Ser Ala Pro Ser Gln Thr Asp Ser 
 2145                2150                2155                2160
Asp Val Pro Pro Glu Thr Glu Glu Cys Pro Ser Ile Thr Ala Asp Ala 
                 2165                2170                2175
Asn Ile Asp Ser Glu Asp Glu Ser Glu Thr Ile Pro Thr Asp Lys Thr 
             2180                2185                2190
Val Thr Tyr Lys His Met Asp Pro Pro Pro Ala Pro Val Gln Asp Arg 
         2195                2200                2205
Ser Pro Ser Pro Arg His Pro Asp Val Ser Met Val Asp Pro Glu Ala 
     2210                2215                2220
Leu Ala Ile Glu Gln Asn Leu Gly Lys Ala Leu Lys Lys Asp Leu Lys 
 2225                2230                2235                2240
Glu Lys Thr Lys Thr Lys Lys Pro Gly Thr Lys Thr Lys Ser Ser Ser 
                 2245                2250                2255
Pro Val Lys Lys Ser Asp Gly Lys Ser Lys Pro Leu Ala Ala Ser Pro 
             2260                2265                2270
Lys Pro Ala Gly Leu Lys Glu Ser Ser Asp Lys Val Ser Arg Val Ala 
         2275                2280                2285
Ser Pro Lys Lys Lys Glu Ser Val Glu Lys Ala Ala Lys Pro Thr Thr 
     2290                2295                2300
Thr Pro Glu Val Lys Ala Ala Arg Gly Glu Glu Lys Asp Lys Glu Thr 
 2305                2310                2315                2320
Lys Asn Ala Ala Asn Ala Ser Ala Ser Lys Ser Ala Lys Thr Ala Thr 
                 2325                2330                2335
Ala Gly Pro Gly Thr Thr Lys Thr Thr Lys Ser Ser Ala Val Pro Pro 
             2340                2345                2350
Gly Leu Pro Val Tyr Leu Asp Leu Cys Tyr Ile Pro Asn His Ser Asn 
         2355                2360                2365
Ser Lys Asn Val Asp Val Glu Phe Phe Lys Arg Val Arg Ser Ser Tyr 
     2370                2375                2380
Tyr Val Val Ser Gly Asn Asp Pro Ala Ala Glu Glu Pro Ser Arg Ala 
 2385                2390                2395                2400
Val Leu Asp Ala Leu Leu Glu Gly Lys Ala Gln Trp Gly Ser Asn Met 
                 2405                2410                2415
Gln Val Thr Leu Ile Pro Thr His Asp Ser Glu Val Met Arg Glu Trp 
             2420                2425                2430
Tyr Gln Glu Thr His Glu Lys Gln Gln Asp Leu Asn Ile Met Val Leu 
         2435                2440                2445
Ala Ser Ser Ser Thr Val Val Met Gln Asp Glu Ser Phe Pro Ala Cys 
     2450                2455                2460
Lys Ile Glu Leu 
 2465



<210> 8649
<211> 487
<212> DNA
<213> Rattus norvegicus
<308> U52950
<400> 8649

gcagagcag  ggagcggcg  gagaggaac  cttctccca  gctttagca  agccggcag  60
atggcgacc  tggtggtgg  agccaccga  ccggagcca  cgggcagca  cggcaaccc  120
gcggcgacc  cctcgccca  cctgtcgca  cgcttccta  acagcaagt  ctacttgct  180
gtggtggtc  gcgagacgg  gaccgaaga  cacctgagg  gtgccatcg  caacatcga  240
ctggggatc  gatcgtggg  gacaaacct  atcgagtgc  acttggacc  agagctcaa  300
cttttcgtg  ctcgacact  cgcgagatt  tctcctgaa  ttccaggac  aaagatcct  360
catcaccga  gtgacgtct  agaaactgt  gttctgatc  acccttcgg  tgaagcagt  420
agcaccgag  tgcgtttgg  gatcactga  gccgcccgc  ataaattgc  ggtgctctc  480
ggacagt  487



<210> 8650
<211> 2459
<212> PRT
<213> Rattus norvegicus
<308> CAC16162
<400> 8650

Met Ala Thr Val Val Val Glu Ala Thr Glu Pro Glu Pro Ser Gly Ser 
  1               5                  10                  15
Ile Gly Asn Pro Ala Ala Thr Thr Ser Pro Ser Leu Ser His Arg Phe 
             20                  25                  30
Leu Asp Ser Lys Phe Tyr Leu Leu Val Val Val Gly Glu Thr Val Thr 
         35                  40                  45
Glu Glu His Leu Arg Arg Ala Ile Gly Asn Ile Glu Leu Gly Ile Arg 
     50                  55                  60
Ser Trp Glu Thr Asn Leu Ile Glu Cys Asn Leu Asp Gln Glu Leu Lys 
 65                  70                  75                  80
Leu Phe Val Ser Arg His Ser Ala Arg Phe Ser Pro Glu Val Pro Gly 
                 85                  90                  95
Gln Lys Ile Leu His His Arg Ser Asp Val Leu Glu Thr Val Val Leu 
             100                105                110
Ile Asn Pro Ser Asp Glu Ala Val Ser Thr Glu Val Arg Leu Met Ile 
         115                120                125
Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln Cys Phe 
     130                135                140
Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser Phe Gln 
 145                150                155                160
Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu Leu Ser 
                 165                170                175
Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys Pro Glu 
             180                185                190
Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu Gln Asp 
         195                200                205
Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu Met Glu 
     210                215                220
Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu Val Pro 
 225                230                235                240
Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Lys 
                 245                250                255
Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly Asp Ser 
             260                265                270
Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly Gly Ser 
         275                280                285
Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp Arg Val 
     290                295                300
Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro Gly Ile 
 305                310                315                320
Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu Ser Gln 
                 325                330                335
Gly Ser Thr Ser Asn Ser Asp Trp Met Lys Asn Leu Ile Ser Pro Asp 
             340                345                350
Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys Asn Pro Glu 
         355                360                365
Pro Asn Ile Lys Met Lys Arg Ser Thr Glu Glu Ala Cys Phe Thr Leu 
     370                375                380
Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu Phe Arg Ser 
 385                390                395                400
Val Gly Asn Ala Ile Glu Pro Val Ile Leu Phe Gln Lys Met Gly Val 
                 405                410                415
Gly Lys Leu Lys Met Tyr Val Leu Asn Pro Val Lys Ser Ser Lys Glu 
             420                425                430
Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys Asp Lys Ala 
         435                440                445
Glu Leu Ile Leu Pro Asn Gly Gln Glu Val Asp Ile Pro Ile Ser Tyr 
     450                455                460
Leu Ala Ser Val Ser Ser Leu Ile Val Trp His Pro Ala Asn Pro Ala 
 465                470                475                480
Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr Gln Tyr Asn 
                 485                490                495
Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe Leu Lys Gln 
             500                505                510
Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Ser Thr Pro Pro 
         515                520                525
Val Lys Gln Val Lys Leu Lys Gln Arg Ala Asp Ser Arg Glu Ser Leu 
     530                535                540
Lys Pro Ala Thr Lys Pro Leu Ser Ser Lys Ser Val Arg Lys Glu Ser 
 545                550                555                560
Lys Glu Glu Ala Pro Glu Ala Thr Lys Ala Ser Gln Val Glu Lys Thr 
                 565                570                575
Pro Lys Val Glu Ser Lys Glu Lys Val Ile Val Lys Lys Asp Lys Pro 
             580                585                590
Gly Lys Val Glu Ser Lys Pro Ser Val Thr Glu Lys Glu Val Pro Ser 
         595                600                605
Lys Glu Glu Gln Ser Pro Val Lys Ala Glu Val Ala Glu Lys Ala Ala 
     610                615                620
Thr Glu Ser Lys Pro Lys Val Thr Lys Asp Lys Val Val Lys Lys Glu 
 625                630                635                640
Ile Lys Thr Lys Pro Glu Glu Lys Lys Glu Glu Lys Pro Lys Lys Glu 
                 645                650                655
Val Ala Lys Lys Glu Asp Lys Thr Pro Leu Lys Lys Asp Glu Lys Pro 
             660                665                670
Lys Lys Glu Glu Ala Lys Lys Glu Ile Lys Lys Glu Ile Lys Lys Glu 
         675                680                685
Glu Lys Lys Glu Leu Lys Lys Glu Val Lys Lys Glu Thr Pro Leu Lys 
     690                695                700
Asp Ala Lys Lys Glu Val Lys Lys Asp Glu Lys Lys Glu Val Lys Lys 
 705                710                715                720
Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys Ile Ser Lys Asp Ile 
                 725                730                735
Lys Lys Ser Thr Pro Leu Ser Asp Thr Lys Lys Pro Ala Ala Leu Lys 
             740                745                750
Pro Lys Val Ala Lys Lys Glu Glu Pro Thr Lys Lys Glu Pro Ile Ala 
         755                760                765
Ala Gly Lys Leu Lys Asp Lys Gly Lys Val Lys Val Ile Lys Lys Glu 
     770                775                780
Gly Lys Thr Thr Glu Ala Ala Ala Thr Ala Val Gly Thr Ala Ala Val 
 785                790                795                800
Ala Ala Ala Ala Gly Val Ala Ala Ser Gly Pro Ala Lys Glu Leu Glu 
                 805                810                815
Ala Glu Arg Ser Leu Met Ser Ser Pro Glu Asp Leu Thr Lys Asp Phe 
             820                825                830
Glu Glu Leu Lys Ala Glu Glu Ile Asp Val Ala Lys Asp Ile Lys Pro 
         835                840                845
Gln Leu Glu Leu Ile Glu Asp Glu Glu Lys Leu Lys Glu Thr Glu Pro 
     850                855                860
Gly Glu Ala Tyr Val Ile Gln Lys Glu Thr Glu Val Ser Lys Gly Ser 
 865                870                875                880
Ala Glu Ser Pro Asp Glu Gly Ile Thr Thr Thr Glu Gly Glu Gly Glu 
                 885                890                895
Cys Glu Gln Thr Pro Glu Glu Leu Glu Pro Val Glu Lys Gln Gly Val 
             900                905                910
Asp Asp Ile Glu Lys Phe Glu Asp Glu Gly Ala Gly Phe Glu Glu Ser 
         915                920                925
Ser Glu Ala Gly Asp Tyr Glu Glu Lys Ala Glu Thr Glu Glu Ala Glu 
     930                935                940
Glu Pro Glu Glu Asp Gly Glu Asp Asn Val Ser Gly Ser Ala Ser Lys 
 945                950                955                960
His Ser Pro Thr Glu Asp Glu Glu Ile Ala Lys Ala Glu Ala Asp Val 
                 965                970                975
His Ile Lys Glu Lys Arg Glu Ser Val Ala Ser Gly Asp Asp Arg Ala 
             980                985                990
Glu Glu Asp Met Asp Glu Ala Leu Glu Lys Gly Glu Ala Glu Gln Ser 
         995                1000                1005
Glu Glu Glu Gly Glu Glu Glu Glu Asp Lys Ala Glu Asp Ala Arg Glu 
     1010                1015                1020
Glu Asp His Glu Pro Asp Lys Thr Glu Ala Glu Asp Tyr Val Met Ala 
 1025                1030                1035                1040
Val Val Asp Lys Ala Ala Glu Ala Gly Val Thr Glu Asp Gln Tyr Asp 
                 1045                1050                1055
Phe Leu Gly Thr Pro Ala Lys Gln Pro Gly Val Gln Ser Pro Ser Arg 
             1060                1065                1070
Glu Pro Ala Ser Ser Ile His Asp Glu Thr Leu Pro Gly Gly Ser Glu 
         1075                1080                1085
Ser Glu Ala Thr Ala Ser Asp Glu Glu Asn Arg Glu Asp Gln Pro Glu 
     1090                1095                1100
Glu Phe Thr Ala Thr Ser Gly Tyr Thr Gln Ser Thr Ile Glu Ile Ser 
 1105                1110                1115                1120
Ser Glu Pro Thr Pro Met Asp Glu Met Ser Thr Pro Arg Asp Val Met 
                 1125                1130                1135
Thr Asp Glu Thr Asn Asn Glu Glu Thr Glu Ser Pro Ser Gln Glu Phe 
             1140                1145                1150
Val Asn Ile Thr Lys Tyr Glu Ser Ser Leu Tyr Ser Gln Glu Tyr Ser 
         1155                1160                1165
Lys Pro Val Val Ala Ser Phe Asn Gly Leu Ser Asp Gly Ser Lys Thr 
     1170                1175                1180
Asp Ala Thr Asp Gly Arg Asp Tyr Asn Ala Ser Ala Ser Thr Ile Ser 
 1185                1190                1195                1200
Pro Pro Ser Ser Met Glu Glu Asp Lys Phe Ser Lys Ser Ala Leu Arg 
                 1205                1210                1215
Asp Ala Tyr Arg Pro Glu Glu Thr Asp Val Lys Thr Gly Ala Glu Leu 
             1220                1225                1230
Asp Ile Lys Asp Val Ser Asp Glu Arg Leu Ser Pro Ala Lys Ser Pro 
         1235                1240                1245
Ser Leu Ser Pro Ser Pro Pro Ser Pro Ile Glu Lys Thr Pro Leu Gly 
     1250                1255                1260
Glu Arg Ser Val Asn Phe Ser Leu Thr Pro Asn Glu Ile Lys Ala Ser 
 1265                1270                1275                1280
Ala Glu Gly Glu Ala Thr Ala Val Val Ser Pro Gly Val Thr Gln Ala 
                 1285                1290                1295
Val Val Glu Glu His Cys Ala Ser Pro Glu Glu Lys Thr Leu Glu Val 
             1300                1305                1310
Val Ser Pro Ser Gln Ser Val Thr Gly Ser Ala Gly His Thr Pro Tyr 
         1315                1320                1325
Tyr Gln Ser Pro Thr Asp Glu Lys Ser Ser His Leu Pro Thr Glu Val 
     1330                1335                1340
Thr Glu Asn Ala Gln Ala Val Pro Val Ser Phe Glu Phe Thr Glu Ala 
 1345                1350                1355                1360
Lys Asp Glu Asn Glu Arg Ser Ser Ile Ser Pro Met Asp Glu Pro Val 
                 1365                1370                1375
Pro Asp Ser Glu Ser Pro Ile Glu Lys Val Leu Ser Pro Leu Arg Ser 
             1380                1385                1390
Pro Pro Leu Ile Gly Ser Glu Ser Ala Tyr Glu Asp Phe Leu Ser Ala 
         1395                1400                1405
Asp Asp Lys Ala Leu Gly Arg Arg Ser Glu Ser Pro Phe Glu Gly Lys 
     1410                1415                1420
Asn Gly Lys Gln Gly Phe Ser Asp Lys Glu Ser Pro Val Ser Asp Leu 
 1425                1430                1435                1440
Thr Ser Asp Leu Tyr Gln Asp Lys Gln Glu Glu Lys Arg Ala Gly Phe 
                 1445                1450                1455
Ile Pro Ile Lys Glu Asp Phe Ser Pro Glu Lys Lys Ala Ser Asp Ala 
             1460                1465                1470
Glu Ile Met Ser Ser Gln Ser Ala Leu Ala Leu Asp Glu Arg Lys Leu 
         1475                1480                1485
Gly Gly Asp Gly Ser Pro Thr Gln Val Asp Val Ser Gln Phe Gly Ser 
     1490                1495                1500
Phe Lys Glu Asp Thr Lys Met Ser Ile Ser Glu Gly Thr Val Ser Asp 
 1505                1510                1515                1520
Lys Ser Ala Thr Pro Val Asp Glu Gly Ala Glu Asp Thr Tyr Ser His 
                 1525                1530                1535
Met Glu Gly Val Ala Ser Val Ser Thr Ala Ser Val Ala Thr Ser Ser 
             1540                1545                1550
Phe Pro Glu Pro Thr Thr Asp Asp Val Ser Pro Ser Leu His Ala Glu 
         1555                1560                1565
Val Gly Ser Pro His Ser Thr Glu Val Asp Asp Ser Leu Ser Val Ser 
     1570                1575                1580
Val Val Gln Thr Pro Thr Thr Phe Gln Glu Thr Glu Met Ser Pro Ser 
 1585                1590                1595                1600
Lys Glu Glu Cys Pro Arg Pro Met Ser Ile Ser Pro Pro Asp Phe Ser 
                 1605                1610                1615
Pro Lys Thr Ala Lys Ser Arg Thr Pro Val Gln Asp His Arg Ser Glu 
             1620                1625                1630
Gln Ser Ser Met Ser Ile Glu Phe Gly Gln Glu Ser Pro Glu His Ser 
         1635                1640                1645
Leu Ala Met Asp Phe Ser Arg Gln Ser Pro Asp His Pro Thr Val Gly 
     1650                1655                1660
Ala Gly Met Leu His Ile Thr Glu Asn Gly Pro Thr Glu Val Asp Tyr 
 1665                1670                1675                1680
Ser Pro Ser Asp Ile Gln Asp Ser Ser Leu Ser His Lys Ile Pro Pro 
                 1685                1690                1695
Thr Glu Glu Pro Ser Tyr Thr Gln Asp Asn Asp Leu Ser Glu Leu Ile 
             1700                1705                1710
Ser Val Ser Gln Val Glu Ala Ser Pro Ser Thr Ser Ser Ala His Thr 
         1715                1720                1725
Pro Ser Gln Ile Ala Ser Pro Leu Gln Glu Asp Thr Leu Ser Asp Val 
     1730                1735                1740
Val Pro Pro Arg Asp Met Ser Leu Tyr Ala Ser Leu Ala Ser Glu Lys 
 1745                1750                1755                1760
Val Gln Ser Leu Glu Gly Glu Lys Leu Ser Pro Lys Ser Asp Ile Ser 
                 1765                1770                1775
Pro Leu Thr Pro Arg Glu Ser Ser Pro Thr Tyr Ser Pro Gly Phe Ser 
             1780                1785                1790
Asp Ser Thr Ser Gly Ala Lys Glu Ser Thr Ala Ala Tyr Gln Thr Ser 
         1795                1800                1805
Ser Ser Pro Pro Ile Asp Ala Ala Ala Ala Glu Pro Tyr Gly Phe Arg 
     1810                1815                1820
Ser Ser Met Leu Phe Asp Thr Met Gln His His Leu Ala Leu Ser Arg 
 1825                1830                1835                1840
Asp Leu Thr Thr Ser Ser Val Glu Lys Asp Asn Gly Gly Lys Thr Pro 
                 1845                1850                1855
Gly Asp Phe Asn Tyr Ala Tyr Gln Lys Pro Glu Ser Thr Thr Glu Ser 
             1860                1865                1870
Pro Asp Glu Glu Asp Tyr Asp Tyr Glu Ser His Glu Lys Thr Ile Gln 
         1875                1880                1885
Ala His Asp Val Gly Gly Tyr Tyr Tyr Glu Lys Thr Glu Arg Thr Ile 
     1890                1895                1900
Lys Ser Pro Cys Asp Ser Gly Tyr Ser Tyr Glu Thr Ile Glu Lys Thr 
 1905                1910                1915                1920
Thr Lys Thr Pro Glu Asp Gly Gly Tyr Ser Cys Glu Ile Thr Glu Lys 
                 1925                1930                1935
Thr Thr Arg Thr Pro Glu Glu Gly Gly Tyr Ser Tyr Glu Ile Ser Glu 
             1940                1945                1950
Lys Thr Thr Arg Thr Pro Glu Val Ser Gly Tyr Thr Tyr Glu Lys Thr 
         1955                1960                1965
Glu Arg Ser Arg Arg Leu Leu Asp Asp Ile Ser Asn Gly Tyr Asp Asp 
     1970                1975                1980
Thr Glu Asp Gly Gly His Thr Leu Gly Asp Cys Ser Tyr Ser Tyr Glu 
 1985                1990                1995                2000
Thr Thr Glu Lys Ile Thr Ser Phe Pro Glu Ser Glu Ser Tyr Ser Tyr 
                 2005                2010                2015
Glu Thr Thr Thr Lys Thr Thr Arg Ser Pro Asp Thr Ser Ala Tyr Cys 
             2020                2025                2030
Tyr Glu Thr Met Glu Lys Ile Thr Lys Thr Pro Gln Ala Ser Thr Tyr 
         2035                2040                2045
Ser Tyr Glu Thr Ser Asp Arg Cys Tyr Thr Pro Glu Arg Lys Ser Pro 
     2050                2055                2060
Ser Glu Ala Arg Gln Asp Val Asp Leu Cys Leu Val Ser Ser Cys Glu 
 2065                2070                2075                2080
Phe Lys His Pro Lys Thr Glu Leu Ser Pro Ser Phe Ile Asn Pro Asn 
                 2085                2090                2095
Pro Leu Glu Trp Phe Ala Gly Glu Glu Pro Thr Glu Glu Ser Glu Arg 
             2100                2105                2110
Pro Leu Thr Gln Ser Gly Gly Ala Pro Pro Pro Ser Gly Gly Lys Gln 
         2115                2120                2125
Gln Gly Arg Gln Cys Asp Glu Thr Pro Pro Thr Ser Val Ser Glu Ser 
     2130                2135                2140
Ala Pro Ser Gln Thr Asp Ser Asp Val Pro Pro Glu Thr Glu Glu Cys 
 2145                2150                2155                2160
Pro Ser Ile Thr Ala Asp Ala Asn Leu Asp Ser Glu Asp Glu Ser Glu 
                 2165                2170                2175
Thr Ile Pro Thr Asp Lys Thr Val Thr Tyr Lys His Met Asp Pro Pro 
             2180                2185                2190
Pro Ala Pro Met Gln Asp Arg Ser Pro Ser Pro Arg His Pro Asp Val 
         2195                2200                2205
Ser Met Val Asp Pro Glu Ala Leu Ala Ile Glu Gln Asn Leu Gly Lys 
     2210                2215                2220
Ala Leu Lys Lys Asp Leu Lys Glu Lys Ala Lys Thr Lys Lys Pro Gly 
 2225                2230                2235                2240
Thr Lys Thr Lys Ser Ser Ser Pro Val Lys Lys Gly Asp Gly Lys Ser 
                 2245                2250                2255
Lys Pro Ser Ala Ala Ser Pro Lys Pro Gly Ala Leu Lys Glu Ser Ser 
             2260                2265                2270
Asp Lys Val Ser Arg Val Ala Ser Pro Lys Lys Lys Glu Ser Val Glu 
         2275                2280                2285
Lys Ala Met Lys Thr Thr Thr Thr Pro Glu Val Lys Ala Thr Arg Gly 
     2290                2295                2300
Glu Glu Lys Asp Lys Glu Thr Lys Asn Ala Ala Asn Ala Ser Ala Ser 
 2305                2310                2315                2320
Lys Ser Val Lys Thr Ala Thr Ala Gly Pro Gly Thr Thr Lys Thr Ala 
                 2325                2330                2335
Lys Ser Ser Thr Val Pro Pro Gly Leu Pro Val Tyr Leu Asp Leu Cys 
             2340                2345                2350
Tyr Ile Pro Asn His Ser Asn Ser Lys Asn Val Asp Val Glu Phe Phe 
         2355                2360                2365
Lys Arg Val Arg Ser Ser Tyr Tyr Val Val Ser Gly Asn Asp Pro Ala 
     2370                2375                2380
Ala Glu Glu Pro Ser Arg Ala Val Leu Asp Ala Leu Leu Glu Gly Lys 
 2385                2390                2395                2400
Ala Gln Trp Gly Ser Asn Met Gln Val Thr Leu Ile Pro Thr His Asp 
                 2405                2410                2415
Ser Glu Val Met Arg Glu Trp Tyr Gln Glu Thr His Glu Lys Gln Gln 
             2420                2425                2430
Asp Leu Asn Ile Met Val Leu Ala Ser Ser Ser Thr Val Val Met Gln 
         2435                2440                2445
Asp Glu Ser Phe Pro Ala Cys Lys Ile Glu Leu 
     2450                2455



<210> 8651
<211> 9416
<212> DNA
<213> Homo sapiens
<308> L06237
<400> 8651

aagcgcgcc  cctccccgc  ctctctcac  ccccgctcc  ctccgccgc  cactctcgc  60
gcgctggga  agggcggag  gggaggcgg  gcgcggcgc  agaggaggg  ggacgcagg  120
ggcggagcg  agacagtac  ttcggagat  atcctttct  ctgccgcag  ggagaggag  180
ggccggagc  agacacttc  ccgaggcac  gcagccggc  ggatggcga  cgtggtggt  240
gaagccacc  agccggagc  gtccggcag  atcgccaac  cggcggcgt  cacctcgcc  300
agcctgtcg  accgcttcc  tgacagcaa  ttctacttg  tggtggtcg  cggcgagat  360
gtgaccgag  agcacctgc  gcgtgccat  ggcaacatc  agctcggaa  ccgatcatg  420
gacacaaac  tgattgaat  caacttgga  caagaactc  aactttttg  atctcgaca  480
tctgcaaga  tctctcctg  agtcccagg  caaaagatc  ttcatcacc  aagtgacgt  540
ttagaaaca  tggtcctga  caacccttc  gatgaagca  tcagcaccg  ggtgcgctt  600
atgatcact  atgctgccc  acacaagct  ctcgtgctg  ccgggcagt  ctttgaaaa  660
accggagag  tcattctcc  gtccggctc  ttctccttc  agaacttca  agagatttt  720
accgatcaa  agatcgggg  gttactaag  accacccat  ctgccaaca  agccagctt  780
accctgttc  gtcctgaag  aggggactg  aagaactcc  atcttgaca  acacaatct  840
caagacttc  tcaatatta  actcaattc  gcttctatc  tgccagaaa  ggaaggact  900
tctgagttt  ccgagtatc  ctcagaatc  gtggaagtc  catctccct  tgacatctt  960
gaacctccc  catcgggtg  atttctgaa  ctctccaag  cctgctgtt  tatttttcc  1020
ggagggagg  gcgattctg  cttgtttgc  gtgaatggt  tcaatatgc  catcaatgg  1080
ggatcagag  gaaaatcct  cttctggaa  ctcatccga  acttagacc  agtggactc  1140
atcctgctc  cccacattg  ggatgacaa  ttgcctgga  taaacagca  gttacagcg  1200
aaaattgca  agctcgagg  agaacagtc  cagggctcc  ccacaaata  tgactggat  1260
aaaaacctc  tctcccctg  cttaggagt  gtatttctc  atgtacctg  aaatctcaa  1320
aatccagag  caaacatca  gatgaagag  agcatagaa  aagcctgct  cactctcca  1380
tacctaaac  aattgtcca  gaaaccaga  cctctgttt  gaagtgtag  caatactat  1440
gatcctgtc  ttcttttcc  aaaaatggg  gtaggtaaa  ttgagatgt  tgtgcttaa  1500
ccagtcaag  gcagcaagg  aatgcagta  tttatgcag  agtggactg  taccaacaa  1560
gacaaggct  aattcattc  gcctaatgg  caagaagta  atctcccga  ttcctactt  1620
acttcagtc  catctttga  tgtgtggca  ccagcaaac  ctgcggaga  aatcatccg  1680
gtcctgttt  ctgggaaca  cacccagta  aacatcctg  aagggttgg  aaagctcaa  1740
catctagac  ttctgaagc  gccactggc  acccaaaag  atctcactg  ccaggtgcc  1800
actcctgtg  tgaaacaaa  aaaactgaa  cagagggct  atagccgag  aagtctgaa  1860
ccagccgca  aaccacttc  tagcaaatc  gtgcgcaag  agtcaaaag  agaaacccc  1920
gaggtcaca  aagtgaatc  cgtggaaaa  ccacccaaa  ttgaaagca  agaaaaggt  1980
atggtgaaa  aagacaagc  agtaaaaac  gagaccaaa  cttcagtga  tgaaaagga  2040
gttcccagc  aagaagagc  atctccagt  aaagccgag  tggctgaga  gcaagccac  2100
gatgtcaaa  ccaaagctg  caaggagaa  acggtgaaa  aggaaacaa  ggtaaagcc  2160
gaagacaag  aagaggaga  agaaaagcc  aagaaagaa  tggctaaaa  ggaggacaa  2220
acacctatc  agaaggagg  aaaaccaaa  aaggaagag  tgaaaaaag  agtcaaaaa  2280
gagatcaag  aagaagaga  aaaagaacc  aagaaagag  ttaagaaag  aacaccgcc  2340
aaggaagtc  agaaggaag  taagaagga  gagaagaag  aagtgaaaa  ggaagaaaa  2400
gaacccaaa  aagaaatta  gaagctccc  aaagacgca  agaaatcat  tactcctct  2460
tctgaagca  aaaaaccag  tgctttaaa  ccaaaagta  ccaagaagg  agagtctgt  2520
aagaaagat  ctgttgctg  cggaaagcc  aaggagaag  ggaaaataa  agtcattaa  2580
aaggaaggc  aggccgcag  ggctgtcgc  gcagctgtc  gcactggag  caccacagc  2640
gctgtcatg  cggcagctg  aatagcagc  attggccct  ccaaagaac  cgaagctga  2700
aggtccctt  tgtcatctc  tgaggatct  accaaggac  ttgaagagt  aaaggctga  2760
gaggtcgat  taacaaagg  catcaagcc  cagctggag  taatcgaag  cgaagagaa  2820
ctgaaggaa  ctgagccag  cgaagccta  gtcatccag  aggagagag  agtcaccaa  2880
ggtcctgcc  agtcccctg  tgagggaat  actaccact  aaggggagg  cgaatgtga  2940
cagacacct  aggagctgg  gcccgtcga  aagcaggga  tagacgaca  tgaaaaatt  3000
gaagatgaa  gagccggtt  tgaagaatc  tcagagact  gagactatg  agagaaggc  3060
gaaactgag  aggctgagg  gccagaaga  gatggggag  aacacgtat  tgtgagcgc  3120
tccaagcac  gccccactg  ggatgagga  agtgccaag  cggaggctg  tgcatacat  3180
agggagaag  gggagtctg  ggccagtgg  gatgaccga  ccgaagaag  catggatga  3240
gccattgag  aaggagagg  tgaacaatc  gaagaggag  ctgatgagg  ggacaaagc  3300
gaagatgcc  gagaggagg  atatgagcc  gaaaaaatg  aagctgaag  ctatgtgat  3360
gctgtggtc  acaaggctg  agaggctgg  ggtgccgag  agcagtatg  attcctcac  3420
acaccaacc  agcaactag  agcccagtc  cctggccga  aacctgcat  ttcaattca  3480
gatgagact  tacctggag  ctcagagag  gaggccacc  cttctgatg  ggagaatcg  3540
gaagaccag  ctgaggaat  cactgccac  tctggctac  ctcagtcta  tattgagat  3600
tccagtgag  ccaccccca  ggatgagat  tctacccct  gagacgtga  gagtgatga  3660
accaacaat  aagagacgg  gtccccttc  caggaattc  taaatatca  caaatatga  3720
tcttcattg  attctcagg  atactctaa  cctgctgat  ttacaccgc  caacggatt  3780
tctgaagga  caaaaacag  tgccactga  ggcaaggat  acaatgctt  agcctctac  3840
atatcacca  cctcttcca  ggaggaaga  aaattcagc  gatctgctt  acgtgatgc  3900
tactgctct  aagtgaaag  cagcaccac  ttggacatc  aagatagca  ctcagctgt  3960
tcaagtgaa  aggtcagcc  atcgaagag  ccgtccctg  gtccatctc  accatcacc  4020
ttagaaaag  cccccctgg  tgaacgtag  gtgaacttc  ctctgacgc  caatgagat  4080
aaagtctct  cagaggcag  agtagcccc  gtgtctcct  aggtgaccc  agaagtagt  4140
gaagaacat  gtgctagtc  tgaggacaa  actctggaa  tggtgtcac  atctcagtc  4200
gtgactggc  gtgctggtc  cacacctta  tatcaatct  ctactgacg  gaaatccag  4260
catctccct  cagaagtca  tgaaaaacc  ccagcagtt  cagtgagtt  tgaattcag  4320
gatgccaaa  atgagaatg  aagggcttc  gtaagcccc  tggatgagc  cgtgcctga  4380
tcagagtct  ctattgaaa  agttttgtc  cctttacgc  gcccgcccc  cattggatc  4440
gagtctgct  atgaaagtt  tctaagtgc  gatgacaag  cttctggca  aggtgccga  4500
agtcctttt  aagaaaaga  tggaaaaca  ggctctcca  accaagtaa  tccagtttc  4560
gaaatgact  ctactagtc  ttaccaaga  aaacaggaa  ggaaaagca  agactttgc  4620
ccaataaaa  aagactttg  ccaagaaaa  aaaactgat  atgttgaag  catgagttc  4680
caaccagca  tggctctgg  tgaaaggaa  ttaggagat  tttctccca  acaaataga  4740
gtcagtcag  ttggatctt  taaagaaga  actaagatg  ccatttctg  aggtactgt  4800
tcagacaag  cagctactc  tgttgatga  ggcgtagca  aagacacgt  ctctcatat  4860
gagggtgtg  cctcagtgt  cacagcctc  gtggctacg  gctcatttc  agagccaac  4920
acagatgat  tgtctccat  tctgcatgc  gaggttggc  ccccacatt  cacagaagt  4980
gatgactcc  tttcagtgt  tgttgtgca  acacctacc  cattccagg  aacagaaat  5040
tctccatct  aagaagaat  cccaagacc  atgtcaatt  ctccaccag  tttctcccc  5100
aaaactgca  agtccagga  acccgttca  gatcacaga  ctgaacagt  ctcaatgtc  5160
attgaattt  gccaagaat  tcctgagca  tcccttgct  tggacttca  tcgacagtc  5220
ccagatcac  ctacagtgg  tgcaggcgt  cttcacatc  ctgaaaatg  gccaactga  5280
gtggactac  gtccttctg  catgcagga  tccagttta  cacataaga  accacctat  5340
gaggagccg  cctacaccc  agataatga  ctttctgag  tcatctcag  atctcaggt  5400
gaggcctcc  cgtccacct  ttctgctca  accccttct  agatcgctt  tcctctcca  5460
gaagatact  tatccgatg  tgctcctcc  agagatatg  ccttatatg  ctcactcac  5520
tctgaaaaa  tgcaaagtc  ggaaggaga  aagctctct  caaaatctg  tatctctcc  5580
ctcacccca  gagagtcct  tcctttata  tcacctact  tttcagatt  tacctctgc  5640
gtcaaagag  aaacagcaa  ttgccacag  tcctcttct  caccaatag  tgcagcatc  5700
gcagagccc  atggcttcc  tgcctcagt  ttattcgat  caatgcaac  ccatctagc  5760
ttgaataga  atttgtcca  acctggcct  gagaaggac  gtggaggga  gacacctgg  5820
gactttagc  atgcctatc  aaagcctga  gaaacaacc  ggtccccag  tgaagaaga  5880
tatgactat  agtcttatg  gaagaccac  cggacctca  atgtgggtg  ctattacta  5940
gagaagata  agagaacca  aaaatctcc  agtgacagt  gctactcct  tgagaccat  6000
gggaaaact  ccaagaccc  tgaagatgg  gactattcc  atgaaatta  tgagaagac  6060
acacggacc  ctgaagagg  cgggtactc  tatgacata  gtgaaaaga  caccagccc  6120
cccgaagtg  gtggttaca  ctatgaaaa  actgagagg  ctagaaggc  tctggatga  6180
atcagcaat  gctatgatg  ctctgagga  ggtggccac  cacttgggg  ccccagcta  6240
tcttatgaa  ccactgaga  aattaccag  ttccctgag  ctgaaggtt  ttcctatga  6300
acatctaca  agacaacac  aacccctga  acttccaca  actgttacg  gactgcaga  6360
aaaatcact  gaacccctc  ggcatccac  tattcctac  agacttcag  cctatgcta  6420
actgcagaa  agaagtccc  ctcagaagc  cgtcaggat  tcgatttat  cctcgtgtc  6480
tcttgtgaa  acaagcacc  caagacaga  ctttcaccc  ctttcatta  tcccaatcc  6540
cttgagtgg  ttgccagtg  agaacccac  gaagaatct  aaaagcccc  cactcaatc  6600
gggggagcc  caccgcctc  aggaggaaa  caacagggc  gacagtgtg  tgaaacccc  6660
cccacctca  tcagcgagt  agccccatc  cagaccgac  ctgatgttc  cccggagac  6720
gaagagtgc  cctccatca  ggccgatgc  aatatcgac  ctgaagacg  gtcggaaac  6780
atccccaca  acaaaactg  cacgtacaa  cacatggac  cacctccag  tcccgtgca  6840
gaccgcagc  cttcgccac  ccaccctga  gtgtccatg  tggacccag  ggccttggc  6900
attgagcag  acctgggca  agctctaaa  aaagatctg  aagagaaga  caaaaccaa  6960
aagccaggt  caaagacca  gtcatcttc  cctgtcaaa  agagtgatg  gaagtctaa  7020
cccttggca  cttcaccaa  accagcggg  ttgaaagaa  cctcggata  agtgtccag  7080
gtggcttct  ctaagaaga  agaatctgt  gaaaaggca  caaaaccca  caccactcc  7140
gaggtcaaa  ctgcacgtg  ggaagagaa  gacaaggag  ccaagaatg  tgccaatgc  7200
tctgcatcc  agtcggcca  gaccgccac  gcaggacca  gaactacca  gacgaccaa  7260
tcatctgct  tgcccccag  cctccctgt  tatttggac  tgtgctaca  tcctaacca  7320
agcaatagt  agaatgttg  tgtggaatt  ttcaagaga  tgcggtctt  ctactacgt  7380
gtgagtggg  atgaccctg  tgctgagga  cccagccgg  ctgtcctgg  cgctttgtt  7440
gaaggaaag  ctcagtggg  cagcaacat  caggtgaca  tgatcccaa  tcatgactc  7500
gaagtgatg  gggaatggt  ccaggagac  catgagaaa  agcaagatc  caacatcat  7560
gttttagca  gcagcagca  agtggttat  caagatgaa  ccttccctg  atgcaagat  7620
gaactgtaa  aaccaaggc  agccacacc  caggatctg  actttgttt  cagaaattc  7680
tcaatttga  atcaccttt  ctaaaaagt  aattcatct  gttaagtcg  tgaacaatt  7740
cctgccaaa  gctatactg  gtcatggtg  tgcaagtca  taaatttct  agtttttgc  7800
gattgctaa  ggaaataac  gtatttcca  aatagggtt  aaattcctg  aaaattacc  7860
accccagtt  atctctgct  aacatttgg  aaccatgca  tagccaacc  aactgactt  7920
tgctaggta  aggcatttg  cttagagag  gagagagcg  gggagagag  gagagagag  7980
gagagcaca  agataacgc  ggagagaga  agagaaaga  tgagaaaga  aaggaatgc  8040
agagaagga  atgtaatga  agagagttc  ggtgagata  ccagagaga  aaagagaga  8100
cagggtggg  taaggagga  aaaataaac  aacaattag  tctgcattt  ctcaggcag  8160
aggcattct  tagtctaca  aggcaaagt  ttccatttt  gtcagtctg  gtcatcaaa  8220
agagtctta  ttttctaaa  caagttggc  agaagaaag  aaaaagaac  acacttgtt  8280
tgagggcat  tgatatttt  acatcttaa  taagctcct  cagtttgaa  gctgcacac  8340
gacataatg  agtgagtgt  gactggcca  gcaagtggt  tgggcccca  tcagaactc  8400
cagactcta  acacacaag  agattgatc  aaggcatgc  cccagcatt  gtccaccca  8460
ttagtccac  ctgagtcga  taacctgca  gcagcaaca  ccaagtcca  cccaattaa  8520
tgaagcaaa  accaaagca  ttgggagta  atatggtag  caatttgcc  taggaagtg  8580
cttgaatgt  caaagatac  tgatgcact  attttttaa  gtgagacag  aagtttata  8640
aacatccat  taggattat  gatacttaa  ggaacacgt  ggtgagcgt  tgtgggggt  8700
ctagaagct  atctgattg  tccaacagt  tgatgctga  tcatgcgtg  tgaatccca  8760
ttcagtgca  ctgtggcct  tcagtcaaa  aagttgtgc  tttcacagc  tctttacta  8820
tgcaagttc  agactgaaa  ggcttctat  atcagaact  ggaaaacag  gaatcttat  8880
gtggaagag  ttctcagca  gtgtacagt  tttaccttc  tttgtctta  attggcttt  8940
taaattttc  attaatttc  acataatta  gggaacaag  gtacagaag  atttttttt  9000
taagatatg  gagaacttt  catagatga  ctttttaac  aatgttttc  tttacagga  9060
attgcaaag  aaattctca  gtgatagtc  tttttttta  gtgtttcgt  agacaaaaa  9120
tgaataatg  tttttgaag  tctggcaag  ttgaagtct  atattgcag  aatgatatt  9180
attaaaaac  cataactac  aggaataat  atacctccc  ccccttgat  cccataaca  9240
aaaagtgct  cttgagagt  ggggagaat  gcatggtag  ctacttttc  gggccttga  9300
aagtacatc  cccagtggt  tcctacata  ttctttcaa  atcttcaac  atgaggtaa  9360
agagccaag  tcaaagaac  ctagcacaa  tttgctttg  gattttctt  tctgga  9416



<210> 8652
<211> 2468
<212> PRT
<213> Homo sapiens
<308> AAA18904
<400> 8652

Met Ala Thr Val Val Val Glu Ala Thr Glu Pro Glu Pro Ser Gly Ser 
  1               5                  10                  15
Ile Ala Asn Pro Ala Ala Ser Thr Ser Pro Ser Leu Ser His Arg Phe 
             20                  25                  30
Leu Asp Ser Lys Phe Tyr Leu Leu Val Val Val Gly Glu Ile Val Thr 
         35                  40                  45
Glu Glu His Leu Arg Arg Ala Ile Gly Asn Ile Glu Leu Gly Ile Arg 
     50                  55                  60
Ser Trp Asp Thr Asn Leu Ile Glu Cys Asn Leu Asp Gln Glu Leu Lys 
 65                  70                  75                  80
Leu Phe Val Ser Arg His Ser Ala Arg Phe Ser Pro Glu Val Pro Gly 
                 85                  90                  95
Gln Lys Ile Leu His His Arg Ser Asp Val Leu Glu Thr Val Val Leu 
             100                105                110
Ile Asn Pro Ser Asp Glu Ala Val Ser Thr Glu Val Arg Leu Met Ile 
         115                120                125
Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln Cys Phe 
     130                135                140
Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser Phe Gln 
 145                150                155                160
Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu Leu Ser 
                 165                170                175
Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys Pro Glu 
             180                185                190
Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu Gln Asp 
         195                200                205
Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu Met Glu 
     210                215                220
Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu Val Pro 
 225                230                235                240
Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Lys 
                 245                250                255
Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly Asp Ser 
             260                265                270
Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly Gly Ser 
         275                280                285
Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp Arg Val 
     290                295                300
Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro Gly Ile 
 305                310                315                320
Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu Gln Ser 
                 325                330                335
Gln Gly Ser Thr Thr Asn Ser Asp Trp Met Lys Asn Leu Ile Ser Pro 
             340                345                350
Asp Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys Asn Pro 
         355                360                365
Glu Pro Asn Ile Lys Met Lys Arg Ser Ile Glu Glu Ala Cys Phe Thr 
     370                375                380
Leu Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu Phe Arg 
 385                390                395                400
Ser Val Gly Asn Thr Ile Asp Pro Val Ile Leu Phe Gln Lys Met Gly 
                 405                410                415
Val Gly Lys Leu Glu Met Tyr Val Leu Asn Pro Val Lys Ser Ser Lys 
             420                425                430
Glu Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys Asp Lys 
         435                440                445
Ala Glu Phe Ile Leu Pro Asn Gly Gln Glu Val Asp Leu Pro Ile Ser 
     450                455                460
Tyr Leu Thr Ser Val Ser Ser Leu Ile Val Trp His Pro Ala Asn Pro 
 465                470                475                480
Ala Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr Gln Tyr 
                 485                490                495
Asn Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe Leu Lys 
             500                505                510
Gln Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Pro Thr Pro 
         515                520                525
Val Val Lys Gln Thr Lys Leu Lys Gln Arg Ala Asp Ser Arg Glu Ser 
     530                535                540
Leu Lys Pro Ala Ala Lys Pro Leu Pro Ser Lys Ser Val Arg Lys Glu 
 545                550                555                560
Ser Lys Glu Glu Thr Pro Glu Val Thr Lys Val Asn His Val Glu Lys 
                 565                570                575
Pro Pro Lys Val Glu Ser Lys Glu Lys Val Met Val Lys Lys Asp Lys 
             580                585                590
Pro Val Lys Thr Glu Thr Lys Pro Ser Val Thr Glu Lys Glu Val Pro 
         595                600                605
Ser Lys Glu Glu Pro Ser Pro Val Lys Ala Glu Val Ala Glu Lys Gln 
     610                615                620
Ala Thr Asp Val Lys Pro Lys Ala Ala Lys Glu Lys Thr Val Lys Lys 
 625                630                635                640
Glu Thr Lys Val Lys Pro Glu Asp Lys Lys Glu Glu Lys Glu Lys Pro 
                 645                650                655
Lys Lys Glu Val Ala Lys Lys Glu Asp Lys Thr Pro Ile Lys Lys Glu 
             660                665                670
Glu Lys Pro Lys Lys Glu Glu Val Lys Lys Glu Val Lys Lys Glu Ile 
         675                680                685
Lys Lys Glu Glu Lys Lys Glu Pro Lys Lys Glu Val Lys Lys Glu Thr 
     690                695                700
Pro Pro Lys Glu Val Lys Lys Glu Val Lys Lys Glu Glu Lys Lys Glu 
 705                710                715                720
Val Lys Lys Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys Leu Pro 
                 725                730                735
Lys Asp Ala Lys Lys Ser Ser Thr Pro Leu Ser Glu Ala Lys Lys Pro 
             740                745                750
Ala Ala Leu Lys Pro Lys Val Pro Lys Lys Glu Glu Ser Val Lys Lys 
         755                760                765
Asp Ser Val Ala Ala Gly Lys Pro Lys Glu Lys Gly Lys Ile Lys Val 
     770                775                780
Ile Lys Lys Glu Gly Lys Ala Ala Glu Ala Val Ala Ala Ala Val Gly 
 785                790                795                800
Thr Gly Ala Thr Thr Ala Ala Val Met Ala Ala Ala Gly Ile Ala Ala 
                 805                810                815
Ile Gly Pro Ala Lys Glu Leu Glu Ala Glu Arg Ser Leu Met Ser Ser 
             820                825                830
Pro Glu Asp Leu Thr Lys Asp Phe Glu Glu Leu Lys Ala Glu Glu Val 
         835                840                845
Asp Val Thr Lys Asp Ile Lys Pro Gln Leu Glu Leu Ile Glu Asp Glu 
     850                855                860
Glu Lys Leu Lys Glu Thr Glu Pro Val Glu Ala Tyr Val Ile Gln Lys 
 865                870                875                880
Glu Arg Glu Val Thr Lys Gly Pro Ala Glu Ser Pro Asp Glu Gly Ile 
                 885                890                895
Thr Thr Thr Glu Gly Glu Gly Glu Cys Glu Gln Thr Pro Glu Glu Leu 
             900                905                910
Glu Pro Val Glu Lys Gln Gly Val Asp Asp Ile Glu Lys Phe Glu Asp 
         915                920                925
Glu Gly Ala Gly Phe Glu Glu Ser Ser Glu Thr Gly Asp Tyr Glu Glu 
     930                935                940
Lys Ala Glu Thr Glu Glu Ala Glu Glu Pro Glu Glu Asp Gly Glu Glu 
 945                950                955                960
His Val Cys Val Ser Ala Ser Lys His Ser Pro Thr Glu Asp Glu Glu 
                 965                970                975
Ser Ala Lys Ala Glu Ala Asp Ala Tyr Ile Arg Glu Lys Arg Glu Ser 
             980                985                990
Val Ala Ser Gly Asp Asp Arg Ala Glu Glu Asp Met Asp Glu Ala Ile 
         995                1000                1005
Glu Lys Gly Glu Ala Glu Gln Ser Glu Glu Glu Ala Asp Glu Glu Asp 
     1010                1015                1020
Lys Ala Glu Asp Ala Arg Glu Glu Glu Tyr Glu Pro Glu Lys Met Glu 
 1025                1030                1035                1040
Ala Glu Asp Tyr Val Met Ala Val Val Asp Lys Ala Ala Glu Ala Gly 
                 1045                1050                1055
Gly Ala Glu Glu Gln Tyr Gly Phe Leu Thr Thr Pro Thr Lys Gln Leu 
             1060                1065                1070
Gly Ala Gln Ser Pro Gly Arg Glu Pro Ala Ser Ser Ile His Asp Glu 
         1075                1080                1085
Thr Leu Pro Gly Gly Ser Glu Ser Glu Ala Thr Ala Ser Asp Glu Glu 
     1090                1095                1100
Asn Arg Glu Asp Gln Pro Glu Glu Phe Thr Ala Thr Ser Gly Tyr Thr 
 1105                1110                1115                1120
Gln Ser Thr Ile Glu Ile Ser Ser Glu Pro Thr Pro Met Asp Glu Met 
                 1125                1130                1135
Ser Thr Pro Arg Asp Val Met Ser Asp Glu Thr Asn Asn Glu Glu Thr 
             1140                1145                1150
Glu Ser Pro Ser Gln Glu Phe Val Asn Ile Thr Lys Tyr Glu Ser Ser 
         1155                1160                1165
Leu Tyr Ser Gln Glu Tyr Ser Lys Pro Ala Asp Val Thr Pro Leu Asn 
     1170                1175                1180
Gly Phe Ser Glu Gly Ser Lys Thr Asp Ala Thr Asp Gly Lys Asp Tyr 
 1185                1190                1195                1200
Asn Ala Ser Ala Ser Thr Ile Ser Pro Pro Ser Ser Met Glu Glu Asp 
                 1205                1210                1215
Lys Phe Ser Arg Ser Ala Leu Arg Asp Ala Tyr Cys Ser Glu Val Lys 
             1220                1225                1230
Ala Ser Thr Thr Leu Asp Ile Lys Asp Ser Ile Ser Ala Val Ser Ser 
         1235                1240                1245
Glu Lys Val Ser Pro Ser Lys Ser Pro Ser Leu Ser Pro Ser Pro Pro 
     1250                1255                1260
Ser Pro Leu Glu Lys Thr Pro Leu Gly Glu Arg Ser Val Asn Phe Ser 
 1265                1270                1275                1280
Leu Thr Pro Asn Glu Ile Lys Val Ser Ala Glu Ala Glu Val Ala Pro 
                 1285                1290                1295
Val Ser Pro Glu Val Thr Gln Glu Val Val Glu Glu His Cys Ala Ser 
             1300                1305                1310
Pro Glu Asp Lys Thr Leu Glu Val Val Ser Pro Ser Gln Ser Val Thr 
         1315                1320                1325
Gly Ser Ala Gly His Thr Pro Tyr Tyr Gln Ser Pro Thr Asp Glu Lys 
     1330                1335                1340
Ser Ser His Leu Pro Thr Glu Val Ile Glu Lys Pro Pro Ala Val Pro 
 1345                1350                1355                1360
Val Ser Phe Glu Phe Ser Asp Ala Lys Asp Glu Asn Glu Arg Ala Ser 
                 1365                1370                1375
Val Ser Pro Met Asp Glu Pro Val Pro Asp Ser Glu Ser Pro Ile Glu 
             1380                1385                1390
Lys Val Leu Ser Pro Leu Arg Ser Pro Pro Leu Ile Gly Ser Glu Ser 
         1395                1400                1405
Ala Tyr Glu Ser Phe Leu Ser Ala Asp Asp Lys Ala Ser Gly Arg Gly 
     1410                1415                1420
Ala Glu Ser Pro Phe Glu Glu Lys Ser Gly Lys Gln Gly Ser Pro Asp 
 1425                1430                1435                1440
Gln Val Ser Pro Val Ser Glu Met Thr Ser Thr Ser Leu Tyr Gln Asp 
                 1445                1450                1455
Lys Gln Glu Gly Lys Ser Thr Asp Phe Ala Pro Ile Lys Glu Asp Phe 
             1460                1465                1470
Gly Gln Glu Lys Lys Thr Asp Asp Val Glu Ala Met Ser Ser Gln Pro 
         1475                1480                1485
Ala Leu Ala Leu Asp Glu Arg Lys Leu Gly Asp Val Ser Pro Thr Gln 
     1490                1495                1500
Ile Asp Val Ser Gln Phe Gly Ser Phe Lys Glu Asp Thr Lys Met Ser 
 1505                1510                1515                1520
Ile Ser Glu Gly Thr Val Ser Asp Lys Ser Ala Thr Pro Val Asp Glu 
                 1525                1530                1535
Gly Val Ala Glu Asp Thr Tyr Ser His Met Glu Gly Val Ala Ser Val 
             1540                1545                1550
Ser Thr Ala Ser Val Ala Thr Ser Ser Phe Pro Glu Pro Thr Thr Asp 
         1555                1560                1565
Asp Val Ser Pro Ser Leu His Ala Glu Val Gly Ser Pro His Ser Thr 
     1570                1575                1580
Glu Val Asp Asp Ser Leu Ser Val Ser Val Val Gln Thr Pro Thr Thr 
 1585                1590                1595                1600
Phe Gln Glu Thr Glu Met Ser Pro Ser Lys Glu Glu Cys Pro Arg Pro 
                 1605                1610                1615
Met Ser Ile Ser Pro Pro Asp Phe Ser Pro Lys Thr Ala Lys Ser Arg 
             1620                1625                1630
Thr Pro Val Gln Asp His Arg Ser Glu Gln Ser Ser Met Ser Ile Glu 
         1635                1640                1645
Phe Gly Gln Glu Ser Pro Glu Gln Ser Leu Ala Met Asp Phe Ser Arg 
     1650                1655                1660
Gln Ser Pro Asp His Pro Thr Val Gly Ala Gly Val Leu His Ile Thr 
 1665                1670                1675                1680
Glu Asn Gly Pro Thr Glu Val Asp Tyr Ser Pro Ser Asp Met Gln Asp 
                 1685                1690                1695
Ser Ser Leu Ser His Lys Ile Pro Pro Met Glu Glu Pro Ser Tyr Thr 
             1700                1705                1710
Gln Asp Asn Asp Leu Ser Glu Leu Ile Ser Val Ser Gln Val Glu Ala 
         1715                1720                1725
Ser Pro Ser Thr Ser Ser Ala His Thr Pro Ser Gln Ile Ala Ser Pro 
     1730                1735                1740
Leu Gln Glu Asp Thr Leu Ser Asp Val Ala Pro Pro Arg Asp Met Ser 
 1745                1750                1755                1760
Leu Tyr Ala Ser Leu Thr Ser Glu Lys Val Gln Ser Leu Glu Gly Glu 
                 1765                1770                1775
Lys Leu Ser Pro Lys Ser Asp Ile Ser Pro Leu Thr Pro Arg Glu Ser 
             1780                1785                1790
Ser Pro Leu Tyr Ser Pro Thr Phe Ser Asp Ser Thr Ser Ala Val Lys 
         1795                1800                1805
Glu Lys Thr Ala Thr Cys His Ser Ser Ser Ser Pro Pro Ile Asp Ala 
     1810                1815                1820
Ala Ser Ala Glu Pro Tyr Gly Phe Arg Ala Ser Val Leu Phe Asp Thr 
 1825                1830                1835                1840
Met Gln His His Leu Ala Leu Asn Arg Asp Leu Ser Thr Pro Gly Leu 
                 1845                1850                1855
Glu Lys Asp Ser Gly Gly Lys Thr Pro Gly Asp Phe Ser Tyr Ala Tyr 
             1860                1865                1870
Gln Lys Pro Glu Glu Thr Thr Arg Ser Pro Asp Glu Glu Asp Tyr Asp 
         1875                1880                1885
Tyr Glu Ser Tyr Glu Lys Thr Thr Arg Thr Ser Asp Val Gly Gly Tyr 
     1890                1895                1900
Tyr Tyr Glu Lys Ile Glu Arg Thr Thr Lys Ser Pro Ser Asp Ser Gly 
 1905                1910                1915                1920
Tyr Ser Tyr Glu Thr Ile Gly Lys Thr Thr Lys Thr Pro Glu Asp Gly 
                 1925                1930                1935
Asp Tyr Ser Tyr Glu Ile Ile Glu Lys Thr Thr Arg Thr Pro Glu Glu 
             1940                1945                1950
Gly Gly Tyr Ser Tyr Asp Ile Ser Glu Lys Thr Thr Ser Pro Pro Glu 
         1955                1960                1965
Val Ser Gly Tyr Ser Tyr Glu Lys Thr Glu Arg Ser Arg Arg Leu Leu 
     1970                1975                1980
Asp Asp Ile Ser Asn Gly Tyr Asp Asp Ser Glu Asp Gly Gly His Thr 
 1985                1990                1995                2000
Leu Gly Asp Pro Ser Tyr Ser Tyr Glu Thr Thr Glu Lys Ile Thr Ser 
                 2005                2010                2015
Phe Pro Glu Ser Glu Gly Tyr Ser Tyr Glu Thr Ser Thr Lys Thr Thr 
             2020                2025                2030
Arg Thr Pro Asp Thr Ser Thr Tyr Cys Tyr Glu Thr Ala Glu Lys Ile 
         2035                2040                2045
Thr Arg Thr Pro Gln Ala Ser Thr Tyr Ser Tyr Glu Thr Ser Asp Leu 
     2050                2055                2060
Cys Tyr Thr Ala Glu Lys Lys Ser Pro Ser Glu Ala Arg Gln Asp Val 
 2065                2070                2075                2080
Asp Leu Cys Leu Val Ser Ser Cys Glu Tyr Lys His Pro Lys Thr Glu 
                 2085                2090                2095
Leu Ser Pro Ser Phe Ile Asn Pro Asn Pro Leu Glu Trp Phe Ala Ser 
             2100                2105                2110
Glu Glu Pro Thr Glu Glu Ser Glu Lys Pro Leu Thr Gln Ser Gly Gly 
         2115                2120                2125
Ala Pro Pro Pro Pro Gly Gly Lys Gln Gln Gly Arg Gln Cys Asp Glu 
     2130                2135                2140
Thr Pro Pro Thr Ser Val Ser Glu Ser Ala Pro Ser Gln Thr Asp Ser 
 2145                2150                2155                2160
Asp Val Pro Pro Glu Thr Glu Glu Cys Pro Ser Ile Thr Ala Asp Ala 
                 2165                2170                2175
Asn Ile Asp Ser Glu Asp Glu Ser Glu Thr Ile Pro Thr Asp Lys Thr 
             2180                2185                2190
Val Thr Tyr Lys His Met Asp Pro Pro Pro Ala Pro Val Gln Asp Arg 
         2195                2200                2205
Ser Pro Ser Pro Arg His Pro Asp Val Ser Met Val Asp Pro Glu Ala 
     2210                2215                2220
Leu Ala Ile Glu Gln Asn Leu Gly Lys Ala Leu Lys Lys Asp Leu Lys 
 2225                2230                2235                2240
Glu Lys Thr Lys Thr Lys Lys Pro Gly Thr Lys Thr Lys Ser Ser Ser 
                 2245                2250                2255
Pro Val Lys Lys Ser Asp Gly Lys Ser Lys Pro Leu Ala Ala Ser Pro 
             2260                2265                2270
Lys Pro Ala Gly Leu Lys Glu Ser Ser Asp Lys Val Ser Arg Val Ala 
         2275                2280                2285
Ser Pro Lys Lys Lys Glu Ser Val Glu Lys Ala Ala Lys Pro Thr Thr 
     2290                2295                2300
Thr Pro Glu Val Lys Ala Ala Arg Gly Glu Glu Lys Asp Lys Glu Thr 
 2305                2310                2315                2320
Lys Asn Ala Ala Asn Ala Ser Ala Ser Lys Ser Ala Lys Thr Ala Thr 
                 2325                2330                2335
Ala Gly Pro Gly Thr Thr Lys Thr Thr Lys Ser Ser Ala Val Pro Pro 
             2340                2345                2350
Gly Leu Pro Val Tyr Leu Asp Leu Cys Tyr Ile Pro Asn His Ser Asn 
         2355                2360                2365
Ser Lys Asn Val Asp Val Glu Phe Phe Lys Arg Val Arg Ser Ser Tyr 
     2370                2375                2380
Tyr Val Val Ser Gly Asn Asp Pro Ala Ala Glu Glu Pro Ser Arg Ala 
 2385                2390                2395                2400
Val Leu Asp Ala Leu Leu Glu Gly Lys Ala Gln Trp Gly Ser Asn Met 
                 2405                2410                2415
Gln Val Thr Leu Ile Pro Thr His Asp Ser Glu Val Met Arg Glu Trp 
             2420                2425                2430
Tyr Gln Glu Thr His Glu Lys Gln Gln Asp Leu Asn Ile Met Val Leu 
         2435                2440                2445
Ala Ser Ser Ser Thr Val Val Met Gln Asp Glu Ser Phe Pro Ala Cys 
     2450                2455                2460
Lys Ile Glu Leu 
 2465



<210> 8653
<211> 487
<212> DNA
<213> Rattus norvegicus
<308> U52950
<400> 8653

gcagagcag  ggagcggcg  gagaggaac  cttctccca  gctttagca  agccggcag  60
atggcgacc  tggtggtgg  agccaccga  ccggagcca  cgggcagca  cggcaaccc  120
gcggcgacc  cctcgccca  cctgtcgca  cgcttccta  acagcaagt  ctacttgct  180
gtggtggtc  gcgagacgg  gaccgaaga  cacctgagg  gtgccatcg  caacatcga  240
ctggggatc  gatcgtggg  gacaaacct  atcgagtgc  acttggacc  agagctcaa  300
cttttcgtg  ctcgacact  cgcgagatt  tctcctgaa  ttccaggac  aaagatcct  360
catcaccga  gtgacgtct  agaaactgt  gttctgatc  acccttcgg  tgaagcagt  420
agcaccgag  tgcgtttgg  gatcactga  gccgcccgc  ataaattgc  ggtgctctc  480
ggacagt  487



<210> 8654
<211> 2459
<212> PRT
<213> Rattus norvegicus
<308> AAB17068
<400> 8654

Met Ala Thr Val Val Val Glu Ala Thr Glu Pro Glu Pro Ser Gly Ser 
  1               5                  10                  15
Ile Gly Asn Pro Ala Ala Thr Thr Ser Pro Ser Leu Ser His Arg Phe 
             20                  25                  30
Leu Asp Ser Lys Phe Tyr Leu Leu Val Val Val Gly Glu Thr Val Thr 
         35                  40                  45
Glu Glu His Leu Arg Arg Ala Ile Gly Asn Ile Glu Leu Gly Ile Arg 
     50                  55                  60
Ser Trp Glu Thr Asn Leu Ile Glu Cys Asn Leu Asp Gln Glu Leu Lys 
 65                  70                  75                  80
Leu Phe Val Ser Arg His Ser Ala Arg Phe Ser Pro Glu Val Pro Gly 
                 85                  90                  95
Gln Lys Ile Leu His His Arg Ser Asp Val Leu Glu Thr Val Val Leu 
             100                105                110
Ile Asn Pro Ser Asp Glu Ala Val Ser Thr Glu Val Arg Leu Met Ile 
         115                120                125
Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln Cys Phe 
     130                135                140
Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser Phe Gln 
 145                150                155                160
Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu Leu Ser 
                 165                170                175
Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys Pro Glu 
             180                185                190
Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu Gln Asp 
         195                200                205
Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu Met Glu 
     210                215                220
Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu Val Pro 
 225                230                235                240
Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Lys 
                 245                250                255
Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly Asp Ser 
             260                265                270
Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly Gly Ser 
         275                280                285
Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp Arg Val 
     290                295                300
Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro Gly Ile 
 305                310                315                320
Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu Ser Gln 
                 325                330                335
Gly Ser Thr Ser Asn Ser Asp Trp Met Lys Asn Leu Ile Ser Pro Asp 
             340                345                350
Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys Asn Pro Glu 
         355                360                365
Pro Asn Ile Lys Met Lys Arg Ser Thr Glu Glu Ala Cys Phe Thr Leu 
     370                375                380
Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu Phe Arg Ser 
 385                390                395                400
Val Gly Asn Ala Ile Glu Pro Val Ile Leu Phe Gln Lys Met Gly Val 
                 405                410                415
Gly Lys Leu Lys Met Tyr Val Leu Asn Pro Val Lys Ser Ser Lys Glu 
             420                425                430
Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys Asp Lys Ala 
         435                440                445
Glu Leu Ile Leu Pro Asn Gly Gln Glu Val Asp Ile Pro Ile Ser Tyr 
     450                455                460
Leu Ala Ser Val Ser Ser Leu Ile Val Trp His Pro Ala Asn Pro Ala 
 465                470                475                480
Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr Gln Tyr Asn 
                 485                490                495
Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe Leu Lys Gln 
             500                505                510
Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Ser Thr Pro Pro 
         515                520                525
Val Lys Gln Val Lys Leu Lys Gln Arg Ala Asp Ser Arg Glu Ser Leu 
     530                535                540
Lys Pro Ala Thr Lys Pro Leu Ser Ser Lys Ser Val Arg Lys Glu Ser 
 545                550                555                560
Lys Glu Glu Ala Pro Glu Ala Thr Lys Ala Ser Gln Val Glu Lys Thr 
                 565                570                575
Pro Lys Val Glu Ser Lys Glu Lys Val Ile Val Lys Lys Asp Lys Pro 
             580                585                590
Gly Lys Val Glu Ser Lys Pro Ser Val Thr Glu Lys Glu Val Pro Ser 
         595                600                605
Lys Glu Glu Gln Ser Pro Val Lys Ala Glu Val Ala Glu Lys Ala Ala 
     610                615                620
Thr Glu Ser Lys Pro Lys Val Thr Lys Asp Lys Val Val Lys Lys Glu 
 625                630                635                640
Ile Lys Thr Lys Pro Glu Glu Lys Lys Glu Glu Lys Pro Lys Lys Glu 
                 645                650                655
Val Ala Lys Lys Glu Asp Lys Thr Pro Leu Lys Lys Asp Glu Lys Pro 
             660                665                670
Lys Lys Glu Glu Ala Lys Lys Glu Ile Lys Lys Glu Ile Lys Lys Glu 
         675                680                685
Glu Lys Lys Glu Leu Lys Lys Glu Val Lys Lys Glu Thr Pro Leu Lys 
     690                695                700
Asp Ala Lys Lys Glu Val Lys Lys Asp Glu Lys Lys Glu Val Lys Lys 
 705                710                715                720
Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys Ile Ser Lys Asp Ile 
                 725                730                735
Lys Lys Ser Thr Pro Leu Ser Asp Thr Lys Lys Pro Ala Ala Leu Lys 
             740                745                750
Pro Lys Val Ala Lys Lys Glu Glu Pro Thr Lys Lys Glu Pro Ile Ala 
         755                760                765
Ala Gly Lys Leu Lys Asp Lys Gly Lys Val Lys Val Ile Lys Lys Glu 
     770                775                780
Gly Lys Thr Thr Glu Ala Ala Ala Thr Ala Val Gly Thr Ala Ala Val 
 785                790                795                800
Ala Ala Ala Ala Gly Val Ala Ala Ser Gly Pro Ala Lys Glu Leu Glu 
                 805                810                815
Ala Glu Arg Ser Leu Met Ser Ser Pro Glu Asp Leu Thr Lys Asp Phe 
             820                825                830
Glu Glu Leu Lys Ala Glu Glu Ile Asp Val Ala Lys Asp Ile Lys Pro 
         835                840                845
Gln Leu Glu Leu Ile Glu Asp Glu Glu Lys Leu Lys Glu Thr Glu Pro 
     850                855                860
Gly Glu Ala Tyr Val Ile Gln Lys Glu Thr Glu Val Ser Lys Gly Ser 
 865                870                875                880
Ala Glu Ser Pro Asp Glu Gly Ile Thr Thr Thr Glu Gly Glu Gly Glu 
                 885                890                895
Cys Glu Gln Thr Pro Glu Glu Leu Glu Pro Val Glu Lys Gln Gly Val 
             900                905                910
Asp Asp Ile Glu Lys Phe Glu Asp Glu Gly Ala Gly Phe Glu Glu Ser 
         915                920                925
Ser Glu Ala Gly Asp Tyr Glu Glu Lys Ala Glu Thr Glu Glu Ala Glu 
     930                935                940
Glu Pro Glu Glu Asp Gly Glu Asp Asn Val Ser Gly Ser Ala Ser Lys 
 945                950                955                960
His Ser Pro Thr Glu Asp Glu Glu Ile Ala Lys Ala Glu Ala Asp Val 
                 965                970                975
His Ile Lys Glu Lys Arg Glu Ser Val Ala Ser Gly Asp Asp Arg Ala 
             980                985                990
Glu Glu Asp Met Asp Glu Ala Leu Glu Lys Gly Glu Ala Glu Gln Ser 
         995                1000                1005
Glu Glu Glu Gly Glu Glu Glu Glu Asp Lys Ala Glu Asp Ala Arg Glu 
     1010                1015                1020
Glu Asp His Glu Pro Asp Lys Thr Glu Ala Glu Asp Tyr Val Met Ala 
 1025                1030                1035                1040
Val Val Asp Lys Ala Ala Glu Ala Gly Val Thr Glu Asp Gln Tyr Asp 
                 1045                1050                1055
Phe Leu Gly Thr Pro Ala Lys Gln Pro Gly Val Gln Ser Pro Ser Arg 
             1060                1065                1070
Glu Pro Ala Ser Ser Ile His Asp Glu Thr Leu Pro Gly Gly Ser Glu 
         1075                1080                1085
Ser Glu Ala Thr Ala Ser Asp Glu Glu Asn Arg Glu Asp Gln Pro Glu 
     1090                1095                1100
Glu Phe Thr Ala Thr Ser Gly Tyr Thr Gln Ser Thr Ile Glu Ile Ser 
 1105                1110                1115                1120
Ser Glu Pro Thr Pro Met Asp Glu Met Ser Thr Pro Arg Asp Val Met 
                 1125                1130                1135
Thr Asp Glu Thr Asn Asn Glu Glu Thr Glu Ser Pro Ser Gln Glu Phe 
             1140                1145                1150
Val Asn Ile Thr Lys Tyr Glu Ser Ser Leu Tyr Ser Gln Glu Tyr Ser 
         1155                1160                1165
Lys Pro Val Val Ala Ser Phe Asn Gly Leu Ser Asp Gly Ser Lys Thr 
     1170                1175                1180
Asp Ala Thr Asp Gly Arg Asp Tyr Asn Ala Ser Ala Ser Thr Ile Ser 
 1185                1190                1195                1200
Pro Pro Ser Ser Met Glu Glu Asp Lys Phe Ser Lys Ser Ala Leu Arg 
                 1205                1210                1215
Asp Ala Tyr Arg Pro Glu Glu Thr Asp Val Lys Thr Gly Ala Glu Leu 
             1220                1225                1230
Asp Ile Lys Asp Val Ser Asp Glu Arg Leu Ser Pro Ala Lys Ser Pro 
         1235                1240                1245
Ser Leu Ser Pro Ser Pro Pro Ser Pro Ile Glu Lys Thr Pro Leu Gly 
     1250                1255                1260
Glu Arg Ser Val Asn Phe Ser Leu Thr Pro Asn Glu Ile Lys Ala Ser 
 1265                1270                1275                1280
Ala Glu Gly Glu Ala Thr Ala Val Val Ser Pro Gly Val Thr Gln Ala 
                 1285                1290                1295
Val Val Glu Glu His Cys Ala Ser Pro Glu Glu Lys Thr Leu Glu Val 
             1300                1305                1310
Val Ser Pro Ser Gln Ser Val Thr Gly Ser Ala Gly His Thr Pro Tyr 
         1315                1320                1325
Tyr Gln Ser Pro Thr Asp Glu Lys Ser Ser His Leu Pro Thr Glu Val 
     1330                1335                1340
Thr Glu Asn Ala Gln Ala Val Pro Val Ser Phe Glu Phe Thr Glu Ala 
 1345                1350                1355                1360
Lys Asp Glu Asn Glu Arg Ser Ser Ile Ser Pro Met Asp Glu Pro Val 
                 1365                1370                1375
Pro Asp Ser Glu Ser Pro Ile Glu Lys Val Leu Ser Pro Leu Arg Ser 
             1380                1385                1390
Pro Pro Leu Ile Gly Ser Glu Ser Ala Tyr Glu Asp Phe Leu Ser Ala 
         1395                1400                1405
Asp Asp Lys Ala Leu Gly Arg Arg Ser Glu Ser Pro Phe Glu Gly Lys 
     1410                1415                1420
Asn Gly Lys Gln Gly Phe Ser Asp Lys Glu Ser Pro Val Ser Asp Leu 
 1425                1430                1435                1440
Thr Ser Asp Leu Tyr Gln Asp Lys Gln Glu Glu Lys Arg Ala Gly Phe 
                 1445                1450                1455
Ile Pro Ile Lys Glu Asp Phe Ser Pro Glu Lys Lys Ala Ser Asp Ala 
             1460                1465                1470
Glu Ile Met Ser Ser Gln Ser Ala Leu Ala Leu Asp Glu Arg Lys Leu 
         1475                1480                1485
Gly Gly Asp Gly Ser Pro Thr Gln Val Asp Val Ser Gln Phe Gly Ser 
     1490                1495                1500
Phe Lys Glu Asp Thr Lys Met Ser Ile Ser Glu Gly Thr Val Ser Asp 
 1505                1510                1515                1520
Lys Ser Ala Thr Pro Val Asp Glu Gly Ala Glu Asp Thr Tyr Ser His 
                 1525                1530                1535
Met Glu Gly Val Ala Ser Val Ser Thr Ala Ser Val Ala Thr Ser Ser 
             1540                1545                1550
Phe Pro Glu Pro Thr Thr Asp Asp Val Ser Pro Ser Leu His Ala Glu 
         1555                1560                1565
Val Gly Ser Pro His Ser Thr Glu Val Asp Asp Ser Leu Ser Val Ser 
     1570                1575                1580
Val Val Gln Thr Pro Thr Thr Phe Gln Glu Thr Glu Met Ser Pro Ser 
 1585                1590                1595                1600
Lys Glu Glu Cys Pro Arg Pro Met Ser Ile Ser Pro Pro Asp Phe Ser 
                 1605                1610                1615
Pro Lys Thr Ala Lys Ser Arg Thr Pro Val Gln Asp His Arg Ser Glu 
             1620                1625                1630
Gln Ser Ser Met Ser Ile Glu Phe Gly Gln Glu Ser Pro Glu His Ser 
         1635                1640                1645
Leu Ala Met Asp Phe Ser Arg Gln Ser Pro Asp His Pro Thr Val Gly 
     1650                1655                1660
Ala Gly Met Leu His Ile Thr Glu Asn Gly Pro Thr Glu Val Asp Tyr 
 1665                1670                1675                1680
Ser Pro Ser Asp Ile Gln Asp Ser Ser Leu Ser His Lys Ile Pro Pro 
                 1685                1690                1695
Thr Glu Glu Pro Ser Tyr Thr Gln Asp Asn Asp Leu Ser Glu Leu Ile 
             1700                1705                1710
Ser Val Ser Gln Val Glu Ala Ser Pro Ser Thr Ser Ser Ala His Thr 
         1715                1720                1725
Pro Ser Gln Ile Ala Ser Pro Leu Gln Glu Asp Thr Leu Ser Asp Val 
     1730                1735                1740
Val Pro Pro Arg Asp Met Ser Leu Tyr Ala Ser Leu Ala Ser Glu Lys 
 1745                1750                1755                1760
Val Gln Ser Leu Glu Gly Glu Lys Leu Ser Pro Lys Ser Asp Ile Ser 
                 1765                1770                1775
Pro Leu Thr Pro Arg Glu Ser Ser Pro Thr Tyr Ser Pro Gly Phe Ser 
             1780                1785                1790
Asp Ser Thr Ser Gly Ala Lys Glu Ser Thr Ala Ala Tyr Gln Thr Ser 
         1795                1800                1805
Ser Ser Pro Pro Ile Asp Ala Ala Ala Ala Glu Pro Tyr Gly Phe Arg 
     1810                1815                1820
Ser Ser Met Leu Phe Asp Thr Met Gln His His Leu Ala Leu Ser Arg 
 1825                1830                1835                1840
Asp Leu Thr Thr Ser Ser Val Glu Lys Asp Asn Gly Gly Lys Thr Pro 
                 1845                1850                1855
Gly Asp Phe Asn Tyr Ala Tyr Gln Lys Pro Glu Ser Thr Thr Glu Ser 
             1860                1865                1870
Pro Asp Glu Glu Asp Tyr Asp Tyr Glu Ser His Glu Lys Thr Ile Gln 
         1875                1880                1885
Ala His Asp Val Gly Gly Tyr Tyr Tyr Glu Lys Thr Glu Arg Thr Ile 
     1890                1895                1900
Lys Ser Pro Cys Asp Ser Gly Tyr Ser Tyr Glu Thr Ile Glu Lys Thr 
 1905                1910                1915                1920
Thr Lys Thr Pro Glu Asp Gly Gly Tyr Ser Cys Glu Ile Thr Glu Lys 
                 1925                1930                1935
Thr Thr Arg Thr Pro Glu Glu Gly Gly Tyr Ser Tyr Glu Ile Ser Glu 
             1940                1945                1950
Lys Thr Thr Arg Thr Pro Glu Val Ser Gly Tyr Thr Tyr Glu Lys Thr 
         1955                1960                1965
Glu Arg Ser Arg Arg Leu Leu Asp Asp Ile Ser Asn Gly Tyr Asp Asp 
     1970                1975                1980
Thr Glu Asp Gly Gly His Thr Leu Gly Asp Cys Ser Tyr Ser Tyr Glu 
 1985                1990                1995                2000
Thr Thr Glu Lys Ile Thr Ser Phe Pro Glu Ser Glu Ser Tyr Ser Tyr 
                 2005                2010                2015
Glu Thr Thr Thr Lys Thr Thr Arg Ser Pro Asp Thr Ser Ala Tyr Cys 
             2020                2025                2030
Tyr Glu Thr Met Glu Lys Ile Thr Lys Thr Pro Gln Ala Ser Thr Tyr 
         2035                2040                2045
Ser Tyr Glu Thr Ser Asp Arg Cys Tyr Thr Pro Glu Arg Lys Ser Pro 
     2050                2055                2060
Ser Glu Ala Arg Gln Asp Val Asp Leu Cys Leu Val Ser Ser Cys Glu 
 2065                2070                2075                2080
Phe Lys His Pro Lys Thr Glu Leu Ser Pro Ser Phe Ile Asn Pro Asn 
                 2085                2090                2095
Pro Leu Glu Trp Phe Ala Gly Glu Glu Pro Thr Glu Glu Ser Glu Arg 
             2100                2105                2110
Pro Leu Thr Gln Ser Gly Gly Ala Pro Pro Pro Ser Gly Gly Lys Gln 
         2115                2120                2125
Gln Gly Arg Gln Cys Asp Glu Thr Pro Pro Thr Ser Val Ser Glu Ser 
     2130                2135                2140
Ala Pro Ser Gln Thr Asp Ser Asp Val Pro Pro Glu Thr Glu Glu Cys 
 2145                2150                2155                2160
Pro Ser Ile Thr Ala Asp Ala Asn Leu Asp Ser Glu Asp Glu Ser Glu 
                 2165                2170                2175
Thr Ile Pro Thr Asp Lys Thr Val Thr Tyr Lys His Met Asp Pro Pro 
             2180                2185                2190
Pro Ala Pro Met Gln Asp Arg Ser Pro Ser Pro Arg His Pro Asp Val 
         2195                2200                2205
Ser Met Val Asp Pro Glu Ala Leu Ala Ile Glu Gln Asn Leu Gly Lys 
     2210                2215                2220
Ala Leu Lys Lys Asp Leu Lys Glu Lys Ala Lys Thr Lys Lys Pro Gly 
 2225                2230                2235                2240
Thr Lys Thr Lys Ser Ser Ser Pro Val Lys Lys Gly Asp Gly Lys Ser 
                 2245                2250                2255
Lys Pro Ser Ala Ala Ser Pro Lys Pro Gly Ala Leu Lys Glu Ser Ser 
             2260                2265                2270
Asp Lys Val Ser Arg Val Ala Ser Pro Lys Lys Lys Glu Ser Val Glu 
         2275                2280                2285
Lys Ala Met Lys Thr Thr Thr Thr Pro Glu Val Lys Ala Thr Arg Gly 
     2290                2295                2300
Glu Glu Lys Asp Lys Glu Thr Lys Asn Ala Ala Asn Ala Ser Ala Ser 
 2305                2310                2315                2320
Lys Ser Val Lys Thr Ala Thr Ala Gly Pro Gly Thr Thr Lys Thr Ala 
                 2325                2330                2335
Lys Ser Ser Thr Val Pro Pro Gly Leu Pro Val Tyr Leu Asp Leu Cys 
             2340                2345                2350
Tyr Ile Pro Asn His Ser Asn Ser Lys Asn Val Asp Val Glu Phe Phe 
         2355                2360                2365
Lys Arg Val Arg Ser Ser Tyr Tyr Val Val Ser Gly Asn Asp Pro Ala 
     2370                2375                2380
Ala Glu Glu Pro Ser Arg Ala Val Leu Asp Ala Leu Leu Glu Gly Lys 
 2385                2390                2395                2400
Ala Gln Trp Gly Ser Asn Met Gln Val Thr Leu Ile Pro Thr His Asp 
                 2405                2410                2415
Ser Glu Val Met Arg Glu Trp Tyr Gln Glu Thr His Glu Lys Gln Gln 
             2420                2425                2430
Asp Leu Asn Ile Met Val Leu Ala Ser Ser Ser Thr Val Val Met Gln 
         2435                2440                2445
Asp Glu Ser Phe Pro Ala Cys Lys Ile Glu Leu 
     2450                2455



<210> 8655
<211> 9416
<212> DNA
<213> Homo sapiens
<308> NM_005909
<400> 8655

aagcgcgcc  cctccccgc  ctctctcac  ccccgctcc  ctccgccgc  cactctcgc  60
gcgctggga  agggcggag  gggaggcgg  gcgcggcgc  agaggaggg  ggacgcagg  120
ggcggagcg  agacagtac  ttcggagat  atcctttct  ctgccgcag  ggagaggag  180
ggccggagc  agacacttc  ccgaggcac  gcagccggc  ggatggcga  cgtggtggt  240
gaagccacc  agccggagc  gtccggcag  atcgccaac  cggcggcgt  cacctcgcc  300
agcctgtcg  accgcttcc  tgacagcaa  ttctacttg  tggtggtcg  cggcgagat  360
gtgaccgag  agcacctgc  gcgtgccat  ggcaacatc  agctcggaa  ccgatcatg  420
gacacaaac  tgattgaat  caacttgga  caagaactc  aactttttg  atctcgaca  480
tctgcaaga  tctctcctg  agtcccagg  caaaagatc  ttcatcacc  aagtgacgt  540
ttagaaaca  tggtcctga  caacccttc  gatgaagca  tcagcaccg  ggtgcgctt  600
atgatcact  atgctgccc  acacaagct  ctcgtgctg  ccgggcagt  ctttgaaaa  660
accggagag  tcattctcc  gtccggctc  ttctccttc  agaacttca  agagatttt  720
accgatcaa  agatcgggg  gttactaag  accacccat  ctgccaaca  agccagctt  780
accctgttc  gtcctgaag  aggggactg  aagaactcc  atcttgaca  acacaatct  840
caagacttc  tcaatatta  actcaattc  gcttctatc  tgccagaaa  ggaaggact  900
tctgagttt  ccgagtatc  ctcagaatc  gtggaagtc  catctccct  tgacatctt  960
gaacctccc  catcgggtg  atttctgaa  ctctccaag  cctgctgtt  tatttttcc  1020
ggagggagg  gcgattctg  cttgtttgc  gtgaatggt  tcaatatgc  catcaatgg  1080
ggatcagag  gaaaatcct  cttctggaa  ctcatccga  acttagacc  agtggactc  1140
atcctgctc  cccacattg  ggatgacaa  ttgcctgga  taaacagca  gttacagcg  1200
aaaattgca  agctcgagg  agaacagtc  cagggctcc  ccacaaata  tgactggat  1260
aaaaacctc  tctcccctg  cttaggagt  gtatttctc  atgtacctg  aaatctcaa  1320
aatccagag  caaacatca  gatgaagag  agcatagaa  aagcctgct  cactctcca  1380
tacctaaac  aattgtcca  gaaaccaga  cctctgttt  gaagtgtag  caatactat  1440
gatcctgtc  ttcttttcc  aaaaatggg  gtaggtaaa  ttgagatgt  tgtgcttaa  1500
ccagtcaag  gcagcaagg  aatgcagta  tttatgcag  agtggactg  taccaacaa  1560
gacaaggct  aattcattc  gcctaatgg  caagaagta  atctcccga  ttcctactt  1620
acttcagtc  catctttga  tgtgtggca  ccagcaaac  ctgcggaga  aatcatccg  1680
gtcctgttt  ctgggaaca  cacccagta  aacatcctg  aagggttgg  aaagctcaa  1740
catctagac  ttctgaagc  gccactggc  acccaaaag  atctcactg  ccaggtgcc  1800
actcctgtg  tgaaacaaa  aaaactgaa  cagagggct  atagccgag  aagtctgaa  1860
ccagccgca  aaccacttc  tagcaaatc  gtgcgcaag  agtcaaaag  agaaacccc  1920
gaggtcaca  aagtgaatc  cgtggaaaa  ccacccaaa  ttgaaagca  agaaaaggt  1980
atggtgaaa  aagacaagc  agtaaaaac  gagaccaaa  cttcagtga  tgaaaagga  2040
gttcccagc  aagaagagc  atctccagt  aaagccgag  tggctgaga  gcaagccac  2100
gatgtcaaa  ccaaagctg  caaggagaa  acggtgaaa  aggaaacaa  ggtaaagcc  2160
gaagacaag  aagaggaga  agaaaagcc  aagaaagaa  tggctaaaa  ggaggacaa  2220
acacctatc  agaaggagg  aaaaccaaa  aaggaagag  tgaaaaaag  agtcaaaaa  2280
gagatcaag  aagaagaga  aaaagaacc  aagaaagag  ttaagaaag  aacaccgcc  2340
aaggaagtc  agaaggaag  taagaagga  gagaagaag  aagtgaaaa  ggaagaaaa  2400
gaacccaaa  aagaaatta  gaagctccc  aaagacgca  agaaatcat  tactcctct  2460
tctgaagca  aaaaaccag  tgctttaaa  ccaaaagta  ccaagaagg  agagtctgt  2520
aagaaagat  ctgttgctg  cggaaagcc  aaggagaag  ggaaaataa  agtcattaa  2580
aaggaaggc  aggccgcag  ggctgtcgc  gcagctgtc  gcactggag  caccacagc  2640
gctgtcatg  cggcagctg  aatagcagc  attggccct  ccaaagaac  cgaagctga  2700
aggtccctt  tgtcatctc  tgaggatct  accaaggac  ttgaagagt  aaaggctga  2760
gaggtcgat  taacaaagg  catcaagcc  cagctggag  taatcgaag  cgaagagaa  2820
ctgaaggaa  ctgagccag  cgaagccta  gtcatccag  aggagagag  agtcaccaa  2880
ggtcctgcc  agtcccctg  tgagggaat  actaccact  aaggggagg  cgaatgtga  2940
cagacacct  aggagctgg  gcccgtcga  aagcaggga  tagacgaca  tgaaaaatt  3000
gaagatgaa  gagccggtt  tgaagaatc  tcagagact  gagactatg  agagaaggc  3060
gaaactgag  aggctgagg  gccagaaga  gatggggag  aacacgtat  tgtgagcgc  3120
tccaagcac  gccccactg  ggatgagga  agtgccaag  cggaggctg  tgcatacat  3180
agggagaag  gggagtctg  ggccagtgg  gatgaccga  ccgaagaag  catggatga  3240
gccattgag  aaggagagg  tgaacaatc  gaagaggag  ctgatgagg  ggacaaagc  3300
gaagatgcc  gagaggagg  atatgagcc  gaaaaaatg  aagctgaag  ctatgtgat  3360
gctgtggtc  acaaggctg  agaggctgg  ggtgccgag  agcagtatg  attcctcac  3420
acaccaacc  agcaactag  agcccagtc  cctggccga  aacctgcat  ttcaattca  3480
gatgagact  tacctggag  ctcagagag  gaggccacc  cttctgatg  ggagaatcg  3540
gaagaccag  ctgaggaat  cactgccac  tctggctac  ctcagtcta  tattgagat  3600
tccagtgag  ccaccccca  ggatgagat  tctacccct  gagacgtga  gagtgatga  3660
accaacaat  aagagacgg  gtccccttc  caggaattc  taaatatca  caaatatga  3720
tcttcattg  attctcagg  atactctaa  cctgctgat  ttacaccgc  caacggatt  3780
tctgaagga  caaaaacag  tgccactga  ggcaaggat  acaatgctt  agcctctac  3840
atatcacca  cctcttcca  ggaggaaga  aaattcagc  gatctgctt  acgtgatgc  3900
tactgctct  aagtgaaag  cagcaccac  ttggacatc  aagatagca  ctcagctgt  3960
tcaagtgaa  aggtcagcc  atcgaagag  ccgtccctg  gtccatctc  accatcacc  4020
ttagaaaag  cccccctgg  tgaacgtag  gtgaacttc  ctctgacgc  caatgagat  4080
aaagtctct  cagaggcag  agtagcccc  gtgtctcct  aggtgaccc  agaagtagt  4140
gaagaacat  gtgctagtc  tgaggacaa  actctggaa  tggtgtcac  atctcagtc  4200
gtgactggc  gtgctggtc  cacacctta  tatcaatct  ctactgacg  gaaatccag  4260
catctccct  cagaagtca  tgaaaaacc  ccagcagtt  cagtgagtt  tgaattcag  4320
gatgccaaa  atgagaatg  aagggcttc  gtaagcccc  tggatgagc  cgtgcctga  4380
tcagagtct  ctattgaaa  agttttgtc  cctttacgc  gcccgcccc  cattggatc  4440
gagtctgct  atgaaagtt  tctaagtgc  gatgacaag  cttctggca  aggtgccga  4500
agtcctttt  aagaaaaga  tggaaaaca  ggctctcca  accaagtaa  tccagtttc  4560
gaaatgact  ctactagtc  ttaccaaga  aaacaggaa  ggaaaagca  agactttgc  4620
ccaataaaa  aagactttg  ccaagaaaa  aaaactgat  atgttgaag  catgagttc  4680
caaccagca  tggctctgg  tgaaaggaa  ttaggagat  tttctccca  acaaataga  4740
gtcagtcag  ttggatctt  taaagaaga  actaagatg  ccatttctg  aggtactgt  4800
tcagacaag  cagctactc  tgttgatga  ggcgtagca  aagacacgt  ctctcatat  4860
gagggtgtg  cctcagtgt  cacagcctc  gtggctacg  gctcatttc  agagccaac  4920
acagatgat  tgtctccat  tctgcatgc  gaggttggc  ccccacatt  cacagaagt  4980
gatgactcc  tttcagtgt  tgttgtgca  acacctacc  cattccagg  aacagaaat  5040
tctccatct  aagaagaat  cccaagacc  atgtcaatt  ctccaccag  tttctcccc  5100
aaaactgca  agtccagga  acccgttca  gatcacaga  ctgaacagt  ctcaatgtc  5160
attgaattt  gccaagaat  tcctgagca  tcccttgct  tggacttca  tcgacagtc  5220
ccagatcac  ctacagtgg  tgcaggcgt  cttcacatc  ctgaaaatg  gccaactga  5280
gtggactac  gtccttctg  catgcagga  tccagttta  cacataaga  accacctat  5340
gaggagccg  cctacaccc  agataatga  ctttctgag  tcatctcag  atctcaggt  5400
gaggcctcc  cgtccacct  ttctgctca  accccttct  agatcgctt  tcctctcca  5460
gaagatact  tatccgatg  tgctcctcc  agagatatg  ccttatatg  ctcactcac  5520
tctgaaaaa  tgcaaagtc  ggaaggaga  aagctctct  caaaatctg  tatctctcc  5580
ctcacccca  gagagtcct  tcctttata  tcacctact  tttcagatt  tacctctgc  5640
gtcaaagag  aaacagcaa  ttgccacag  tcctcttct  caccaatag  tgcagcatc  5700
gcagagccc  atggcttcc  tgcctcagt  ttattcgat  caatgcaac  ccatctagc  5760
ttgaataga  atttgtcca  acctggcct  gagaaggac  gtggaggga  gacacctgg  5820
gactttagc  atgcctatc  aaagcctga  gaaacaacc  ggtccccag  tgaagaaga  5880
tatgactat  agtcttatg  gaagaccac  cggacctca  atgtgggtg  ctattacta  5940
gagaagata  agagaacca  aaaatctcc  agtgacagt  gctactcct  tgagaccat  6000
gggaaaact  ccaagaccc  tgaagatgg  gactattcc  atgaaatta  tgagaagac  6060
acacggacc  ctgaagagg  tgggtactc  tatgacata  gtgaaaaga  caccagccc  6120
cccgaagtg  gtggttaca  ctatgaaaa  actgagagg  ctagaaggc  tctggatga  6180
atcagcaat  gctatgatg  ctctgagga  ggtggccac  cacttgggg  ccccagcta  6240
tcttatgaa  ccactgaga  aattaccag  ttccctgag  ctgaaggtt  ttcctatga  6300
acatctaca  agacaacac  aacccctga  acttccaca  actgttacg  gactgcaga  6360
aaaatcact  gaacccctc  ggcatccac  tattcctac  agacttcag  cctatgcta  6420
actgcagaa  agaagtccc  ctcagaagc  cgtcaggat  tcgatttat  cctcgtgtc  6480
tcttgtgaa  acaagcacc  caagacaga  ctttcaccc  ctttcatta  tcccaatcc  6540
cttgagtgg  ttgccagtg  agaacccac  gaagaatct  aaaagcccc  cactcaatc  6600
gggggagcc  caccgcctc  aggaggaaa  caacagggc  gacagtgtg  tgaaacccc  6660
cccacctca  tcagcgagt  agccccatc  cagaccgac  ctgatgttc  cccggagac  6720
gaagagtgc  cctccatca  ggccgatgc  aatatcgac  ctgaagacg  gtcggaaac  6780
atccccaca  acaaaactg  cacgtacaa  cacatggac  cacctccag  tcccgtgca  6840
gaccgcagc  cttcgccac  ccaccctga  gtgtccatg  tggacccag  ggccttggc  6900
attgagcag  acctgggca  agctctaaa  aaagatctg  aagagaaga  caaaaccaa  6960
aagccaggt  caaagacca  gtcatcttc  cctgtcaaa  agagtgatg  gaagtctaa  7020
cccttggca  cttcaccaa  accagcggg  ttgaaagaa  cctcggata  agtgtccag  7080
gtggcttct  ctaagaaga  agaatctgt  gaaaaggca  caaaaccca  caccactcc  7140
gaggtcaaa  ctgcacgtg  ggaagagaa  gacaaggag  ccaagaatg  tgccaatgc  7200
tctgcatcc  agtcggcca  gaccgccac  gcaggacca  gaactacca  gacgaccaa  7260
tcatctgct  tgcccccag  cctccctgt  tatttggac  tgtgctaca  tcctaacca  7320
agcaatagt  agaatgttg  tgtggaatt  ttcaagaga  tgcggtctt  ctactacgt  7380
gtgagtggg  atgaccctg  tgctgagga  cccagccgg  ctgtcctgg  cgctttgtt  7440
gaaggaaag  ctcagtggg  cagcaacat  caggtgaca  tgatcccaa  tcatgactc  7500
gaagtgatg  gggaatggt  ccaggagac  catgagaaa  agcaagatc  caacatcat  7560
gttttagca  gcagcagca  agtggttat  caagatgaa  ccttccctg  atgcaagat  7620
gaactgtaa  aaccaaggc  agccacacc  caggatctg  actttgttt  cagaaattc  7680
tcaatttga  atcaccttt  ctaaaaagt  aattcatct  gttaagtcg  tgaacaatt  7740
cctgccaaa  gctatactg  gtcatggtg  tgcaagtca  taaatttct  agtttttgc  7800
gattgctaa  ggaaataac  gtatttcca  aatagggtt  aaattcctg  aaaattacc  7860
accccagtt  atctctgct  aacatttgg  aaccatgca  tagccaacc  aactgactt  7920
tgctaggta  aggcatttg  cttagagag  gagagagcg  gggagagag  gagagagag  7980
gagagcaca  agataacgc  ggagagaga  agagaaaga  tgagaaaga  aaggaatgc  8040
agagaagga  atgtaatga  agagagttc  ggtgagata  ccagagaga  aaagagaga  8100
cagggtggg  taaggagga  aaaataaac  aacaattag  tctgcattt  ctcaggcag  8160
aggcattct  tagtctaca  aggcaaagt  ttccatttt  gtcagtctg  gtcatcaaa  8220
agagtctta  ttttctaaa  caagttggc  agaagaaag  aaaaagaac  acacttgtt  8280
tgagggcat  tgatatttt  acatcttaa  taagctcct  cagtttgaa  gctgcacac  8340
gacataatg  agtgagtgt  gactggcca  gcaagtggt  tgggcccca  tcagaactc  8400
cagactcta  acacacaag  agattgatc  aaggcatgc  cccagcatt  gtccaccca  8460
ttagtccac  ctgagtcga  taacctgca  gcagcaaca  ccaagtcca  cccaattaa  8520
tgaagcaaa  accaaagca  ttgggagta  atatggtag  caatttgcc  taggaagtg  8580
cttgaatgt  caaagatac  tgatgcact  attttttaa  gtgagacag  aagtttata  8640
aacatccat  taggattat  gatacttaa  ggaacacgt  ggtgagcgt  tgtgggggt  8700
ctagaagct  atctgattg  tccaacagt  tgatgctga  tcatgcgtg  tgaatccca  8760
ttcagtgca  ctgtggcct  tcagtcaaa  aagttgtgc  tttcacagc  tctttacta  8820
tgcaagttc  agactgaaa  ggcttctat  atcagaact  ggaaaacag  gaatcttat  8880
gtggaagag  ttctcagca  gtgtacagt  tttaccttc  tttgtctta  attggcttt  8940
taaattttc  attaatttc  acataatta  gggaacaag  gtacagaag  atttttttt  9000
taagatatg  gagaacttt  catagatga  ctttttaac  aatgttttc  tttacagga  9060
attgcaaag  aaattctca  gtgatagtc  tttttttta  gtgtttcgt  agacaaaaa  9120
tgaataatg  tttttgaag  tctggcaag  ttgaagtct  atattgcag  aatgatatt  9180
attaaaaac  cataactac  aggaataat  atacctccc  ccccttgat  cccataaca  9240
aaaagtgct  cttgagagt  ggggagaat  gcatggtag  ctacttttc  gggccttga  9300
aagtacatc  cccagtggt  tcctacata  ttctttcaa  atcttcaac  atgaggtaa  9360
agagccaag  tcaaagaac  ctagcacaa  tttgctttg  gattttctt  tctgga  9416



<210> 8656
<211> 2468
<212> PRT
<213> Homo sapiens
<308> NP_005900
<400> 8656

Met Ala Thr Val Val Val Glu Ala Thr Glu Pro Glu Pro Ser Gly Ser 
  1               5                  10                  15
Ile Ala Asn Pro Ala Ala Ser Thr Ser Pro Ser Leu Ser His Arg Phe 
             20                  25                  30
Leu Asp Ser Lys Phe Tyr Leu Leu Val Val Val Gly Glu Ile Val Thr 
         35                  40                  45
Glu Glu His Leu Arg Arg Ala Ile Gly Asn Ile Glu Leu Gly Ile Arg 
     50                  55                  60
Ser Trp Asp Thr Asn Leu Ile Glu Cys Asn Leu Asp Gln Glu Leu Lys 
 65                  70                  75                  80
Leu Phe Val Ser Arg His Ser Ala Arg Phe Ser Pro Glu Val Pro Gly 
                 85                  90                  95
Gln Lys Ile Leu His His Arg Ser Asp Val Leu Glu Thr Val Val Leu 
             100                105                110
Ile Asn Pro Ser Asp Glu Ala Val Ser Thr Glu Val Arg Leu Met Ile 
         115                120                125
Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln Cys Phe 
     130                135                140
Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser Phe Gln 
 145                150                155                160
Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu Leu Ser 
                 165                170                175
Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys Pro Glu 
             180                185                190
Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu Gln Asp 
         195                200                205
Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu Met Glu 
     210                215                220
Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu Val Pro 
 225                230                235                240
Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Lys 
                 245                250                255
Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly Asp Ser 
             260                265                270
Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly Gly Ser 
         275                280                285
Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp Arg Val 
     290                295                300
Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro Gly Ile 
 305                310                315                320
Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu Gln Ser 
                 325                330                335
Gln Gly Ser Thr Thr Asn Ser Asp Trp Met Lys Asn Leu Ile Ser Pro 
             340                345                350
Asp Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys Asn Pro 
         355                360                365
Glu Pro Asn Ile Lys Met Lys Arg Ser Ile Glu Glu Ala Cys Phe Thr 
     370                375                380
Leu Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu Phe Arg 
 385                390                395                400
Ser Val Gly Asn Thr Ile Asp Pro Val Ile Leu Phe Gln Lys Met Gly 
                 405                410                415
Val Gly Lys Leu Glu Met Tyr Val Leu Asn Pro Val Lys Ser Ser Lys 
             420                425                430
Glu Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys Asp Lys 
         435                440                445
Ala Glu Phe Ile Leu Pro Asn Gly Gln Glu Val Asp Leu Pro Ile Ser 
     450                455                460
Tyr Leu Thr Ser Val Ser Ser Leu Ile Val Trp His Pro Ala Asn Pro 
 465                470                475                480
Ala Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr Gln Tyr 
                 485                490                495
Asn Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe Leu Lys 
             500                505                510
Gln Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Pro Thr Pro 
         515                520                525
Val Val Lys Gln Thr Lys Leu Lys Gln Arg Ala Asp Ser Arg Glu Ser 
     530                535                540
Leu Lys Pro Ala Ala Lys Pro Leu Pro Ser Lys Ser Val Arg Lys Glu 
 545                550                555                560
Ser Lys Glu Glu Thr Pro Glu Val Thr Lys Val Asn His Val Glu Lys 
                 565                570                575
Pro Pro Lys Val Glu Ser Lys Glu Lys Val Met Val Lys Lys Asp Lys 
             580                585                590
Pro Val Lys Thr Glu Thr Lys Pro Ser Val Thr Glu Lys Glu Val Pro 
         595                600                605
Ser Lys Glu Glu Pro Ser Pro Val Lys Ala Glu Val Ala Glu Lys Gln 
     610                615                620
Ala Thr Asp Val Lys Pro Lys Ala Ala Lys Glu Lys Thr Val Lys Lys 
 625                630                635                640
Glu Thr Lys Val Lys Pro Glu Asp Lys Lys Glu Glu Lys Glu Lys Pro 
                 645                650                655
Lys Lys Glu Val Ala Lys Lys Glu Asp Lys Thr Pro Ile Lys Lys Glu 
             660                665                670
Glu Lys Pro Lys Lys Glu Glu Val Lys Lys Glu Val Lys Lys Glu Ile 
         675                680                685
Lys Lys Glu Glu Lys Lys Glu Pro Lys Lys Glu Val Lys Lys Glu Thr 
     690                695                700
Pro Pro Lys Glu Val Lys Lys Glu Val Lys Lys Glu Glu Lys Lys Glu 
 705                710                715                720
Val Lys Lys Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys Leu Pro 
                 725                730                735
Lys Asp Ala Lys Lys Ser Ser Thr Pro Leu Ser Glu Ala Lys Lys Pro 
             740                745                750
Ala Ala Leu Lys Pro Lys Val Pro Lys Lys Glu Glu Ser Val Lys Lys 
         755                760                765
Asp Ser Val Ala Ala Gly Lys Pro Lys Glu Lys Gly Lys Ile Lys Val 
     770                775                780
Ile Lys Lys Glu Gly Lys Ala Ala Glu Ala Val Ala Ala Ala Val Gly 
 785                790                795                800
Thr Gly Ala Thr Thr Ala Ala Val Met Ala Ala Ala Gly Ile Ala Ala 
                 805                810                815
Ile Gly Pro Ala Lys Glu Leu Glu Ala Glu Arg Ser Leu Met Ser Ser 
             820                825                830
Pro Glu Asp Leu Thr Lys Asp Phe Glu Glu Leu Lys Ala Glu Glu Val 
         835                840                845
Asp Val Thr Lys Asp Ile Lys Pro Gln Leu Glu Leu Ile Glu Asp Glu 
     850                855                860
Glu Lys Leu Lys Glu Thr Glu Pro Val Glu Ala Tyr Val Ile Gln Lys 
 865                870                875                880
Glu Arg Glu Val Thr Lys Gly Pro Ala Glu Ser Pro Asp Glu Gly Ile 
                 885                890                895
Thr Thr Thr Glu Gly Glu Gly Glu Cys Glu Gln Thr Pro Glu Glu Leu 
             900                905                910
Glu Pro Val Glu Lys Gln Gly Val Asp Asp Ile Glu Lys Phe Glu Asp 
         915                920                925
Glu Gly Ala Gly Phe Glu Glu Ser Ser Glu Thr Gly Asp Tyr Glu Glu 
     930                935                940
Lys Ala Glu Thr Glu Glu Ala Glu Glu Pro Glu Glu Asp Gly Glu Glu 
 945                950                955                960
His Val Cys Val Ser Ala Ser Lys His Ser Pro Thr Glu Asp Glu Glu 
                 965                970                975
Ser Ala Lys Ala Glu Ala Asp Ala Tyr Ile Arg Glu Lys Arg Glu Ser 
             980                985                990
Val Ala Ser Gly Asp Asp Arg Ala Glu Glu Asp Met Asp Glu Ala Ile 
         995                1000                1005
Glu Lys Gly Glu Ala Glu Gln Ser Glu Glu Glu Ala Asp Glu Glu Asp 
     1010                1015                1020
Lys Ala Glu Asp Ala Arg Glu Glu Glu Tyr Glu Pro Glu Lys Met Glu 
 1025                1030                1035                1040
Ala Glu Asp Tyr Val Met Ala Val Val Asp Lys Ala Ala Glu Ala Gly 
                 1045                1050                1055
Gly Ala Glu Glu Gln Tyr Gly Phe Leu Thr Thr Pro Thr Lys Gln Leu 
             1060                1065                1070
Gly Ala Gln Ser Pro Gly Arg Glu Pro Ala Ser Ser Ile His Asp Glu 
         1075                1080                1085
Thr Leu Pro Gly Gly Ser Glu Ser Glu Ala Thr Ala Ser Asp Glu Glu 
     1090                1095                1100
Asn Arg Glu Asp Gln Pro Glu Glu Phe Thr Ala Thr Ser Gly Tyr Thr 
 1105                1110                1115                1120
Gln Ser Thr Ile Glu Ile Ser Ser Glu Pro Thr Pro Met Asp Glu Met 
                 1125                1130                1135
Ser Thr Pro Arg Asp Val Met Ser Asp Glu Thr Asn Asn Glu Glu Thr 
             1140                1145                1150
Glu Ser Pro Ser Gln Glu Phe Val Asn Ile Thr Lys Tyr Glu Ser Ser 
         1155                1160                1165
Leu Tyr Ser Gln Glu Tyr Ser Lys Pro Ala Asp Val Thr Pro Leu Asn 
     1170                1175                1180
Gly Phe Ser Glu Gly Ser Lys Thr Asp Ala Thr Asp Gly Lys Asp Tyr 
 1185                1190                1195                1200
Asn Ala Ser Ala Ser Thr Ile Ser Pro Pro Ser Ser Met Glu Glu Asp 
                 1205                1210                1215
Lys Phe Ser Arg Ser Ala Leu Arg Asp Ala Tyr Cys Ser Glu Val Lys 
             1220                1225                1230
Ala Ser Thr Thr Leu Asp Ile Lys Asp Ser Ile Ser Ala Val Ser Ser 
         1235                1240                1245
Glu Lys Val Ser Pro Ser Lys Ser Pro Ser Leu Ser Pro Ser Pro Pro 
     1250                1255                1260
Ser Pro Leu Glu Lys Thr Pro Leu Gly Glu Arg Ser Val Asn Phe Ser 
 1265                1270                1275                1280
Leu Thr Pro Asn Glu Ile Lys Val Ser Ala Glu Ala Glu Val Ala Pro 
                 1285                1290                1295
Val Ser Pro Glu Val Thr Gln Glu Val Val Glu Glu His Cys Ala Ser 
             1300                1305                1310
Pro Glu Asp Lys Thr Leu Glu Val Val Ser Pro Ser Gln Ser Val Thr 
         1315                1320                1325
Gly Ser Ala Gly His Thr Pro Tyr Tyr Gln Ser Pro Thr Asp Glu Lys 
     1330                1335                1340
Ser Ser His Leu Pro Thr Glu Val Ile Glu Lys Pro Pro Ala Val Pro 
 1345                1350                1355                1360
Val Ser Phe Glu Phe Ser Asp Ala Lys Asp Glu Asn Glu Arg Ala Ser 
                 1365                1370                1375
Val Ser Pro Met Asp Glu Pro Val Pro Asp Ser Glu Ser Pro Ile Glu 
             1380                1385                1390
Lys Val Leu Ser Pro Leu Arg Ser Pro Pro Leu Ile Gly Ser Glu Ser 
         1395                1400                1405
Ala Tyr Glu Ser Phe Leu Ser Ala Asp Asp Lys Ala Ser Gly Arg Gly 
     1410                1415                1420
Ala Glu Ser Pro Phe Glu Glu Lys Ser Gly Lys Gln Gly Ser Pro Asp 
 1425                1430                1435                1440
Gln Val Ser Pro Val Ser Glu Met Thr Ser Thr Ser Leu Tyr Gln Asp 
                 1445                1450                1455
Lys Gln Glu Gly Lys Ser Thr Asp Phe Ala Pro Ile Lys Glu Asp Phe 
             1460                1465                1470
Gly Gln Glu Lys Lys Thr Asp Asp Val Glu Ala Met Ser Ser Gln Pro 
         1475                1480                1485
Ala Leu Ala Leu Asp Glu Arg Lys Leu Gly Asp Val Ser Pro Thr Gln 
     1490                1495                1500
Ile Asp Val Ser Gln Phe Gly Ser Phe Lys Glu Asp Thr Lys Met Ser 
 1505                1510                1515                1520
Ile Ser Glu Gly Thr Val Ser Asp Lys Ser Ala Thr Pro Val Asp Glu 
                 1525                1530                1535
Gly Val Ala Glu Asp Thr Tyr Ser His Met Glu Gly Val Ala Ser Val 
             1540                1545                1550
Ser Thr Ala Ser Val Ala Thr Ser Ser Phe Pro Glu Pro Thr Thr Asp 
         1555                1560                1565
Asp Val Ser Pro Ser Leu His Ala Glu Val Gly Ser Pro His Ser Thr 
     1570                1575                1580
Glu Val Asp Asp Ser Leu Ser Val Ser Val Val Gln Thr Pro Thr Thr 
 1585                1590                1595                1600
Phe Gln Glu Thr Glu Met Ser Pro Ser Lys Glu Glu Cys Pro Arg Pro 
                 1605                1610                1615
Met Ser Ile Ser Pro Pro Asp Phe Ser Pro Lys Thr Ala Lys Ser Arg 
             1620                1625                1630
Thr Pro Val Gln Asp His Arg Ser Glu Gln Ser Ser Met Ser Ile Glu 
         1635                1640                1645
Phe Gly Gln Glu Ser Pro Glu Gln Ser Leu Ala Met Asp Phe Ser Arg 
     1650                1655                1660
Gln Ser Pro Asp His Pro Thr Val Gly Ala Gly Val Leu His Ile Thr 
 1665                1670                1675                1680
Glu Asn Gly Pro Thr Glu Val Asp Tyr Ser Pro Ser Asp Met Gln Asp 
                 1685                1690                1695
Ser Ser Leu Ser His Lys Ile Pro Pro Met Glu Glu Pro Ser Tyr Thr 
             1700                1705                1710
Gln Asp Asn Asp Leu Ser Glu Leu Ile Ser Val Ser Gln Val Glu Ala 
         1715                1720                1725
Ser Pro Ser Thr Ser Ser Ala His Thr Pro Ser Gln Ile Ala Ser Pro 
     1730                1735                1740
Leu Gln Glu Asp Thr Leu Ser Asp Val Ala Pro Pro Arg Asp Met Ser 
 1745                1750                1755                1760
Leu Tyr Ala Ser Leu Thr Ser Glu Lys Val Gln Ser Leu Glu Gly Glu 
                 1765                1770                1775
Lys Leu Ser Pro Lys Ser Asp Ile Ser Pro Leu Thr Pro Arg Glu Ser 
             1780                1785                1790
Ser Pro Leu Tyr Ser Pro Thr Phe Ser Asp Ser Thr Ser Ala Val Lys 
         1795                1800                1805
Glu Lys Thr Ala Thr Cys His Ser Ser Ser Ser Pro Pro Ile Asp Ala 
     1810                1815                1820
Ala Ser Ala Glu Pro Tyr Gly Phe Arg Ala Ser Val Leu Phe Asp Thr 
 1825                1830                1835                1840
Met Gln His His Leu Ala Leu Asn Arg Asp Leu Ser Thr Pro Gly Leu 
                 1845                1850                1855
Glu Lys Asp Ser Gly Gly Lys Thr Pro Gly Asp Phe Ser Tyr Ala Tyr 
             1860                1865                1870
Gln Lys Pro Glu Glu Thr Thr Arg Ser Pro Asp Glu Glu Asp Tyr Asp 
         1875                1880                1885
Tyr Glu Ser Tyr Glu Lys Thr Thr Arg Thr Ser Asp Val Gly Gly Tyr 
     1890                1895                1900
Tyr Tyr Glu Lys Ile Glu Arg Thr Thr Lys Ser Pro Ser Asp Ser Gly 
 1905                1910                1915                1920
Tyr Ser Tyr Glu Thr Ile Gly Lys Thr Thr Lys Thr Pro Glu Asp Gly 
                 1925                1930                1935
Asp Tyr Ser Tyr Glu Ile Ile Glu Lys Thr Thr Arg Thr Pro Glu Glu 
             1940                1945                1950
Gly Gly Tyr Ser Tyr Asp Ile Ser Glu Lys Thr Thr Ser Pro Pro Glu 
         1955                1960                1965
Val Ser Gly Tyr Ser Tyr Glu Lys Thr Glu Arg Ser Arg Arg Leu Leu 
     1970                1975                1980
Asp Asp Ile Ser Asn Gly Tyr Asp Asp Ser Glu Asp Gly Gly His Thr 
 1985                1990                1995                2000
Leu Gly Asp Pro Ser Tyr Ser Tyr Glu Thr Thr Glu Lys Ile Thr Ser 
                 2005                2010                2015
Phe Pro Glu Ser Glu Gly Tyr Ser Tyr Glu Thr Ser Thr Lys Thr Thr 
             2020                2025                2030
Arg Thr Pro Asp Thr Ser Thr Tyr Cys Tyr Glu Thr Ala Glu Lys Ile 
         2035                2040                2045
Thr Arg Thr Pro Gln Ala Ser Thr Tyr Ser Tyr Glu Thr Ser Asp Leu 
     2050                2055                2060
Cys Tyr Thr Ala Glu Lys Lys Ser Pro Ser Glu Ala Arg Gln Asp Val 
 2065                2070                2075                2080
Asp Leu Cys Leu Val Ser Ser Cys Glu Tyr Lys His Pro Lys Thr Glu 
                 2085                2090                2095
Leu Ser Pro Ser Phe Ile Asn Pro Asn Pro Leu Glu Trp Phe Ala Ser 
             2100                2105                2110
Glu Glu Pro Thr Glu Glu Ser Glu Lys Pro Leu Thr Gln Ser Gly Gly 
         2115                2120                2125
Ala Pro Pro Pro Pro Gly Gly Lys Gln Gln Gly Arg Gln Cys Asp Glu 
     2130                2135                2140
Thr Pro Pro Thr Ser Val Ser Glu Ser Ala Pro Ser Gln Thr Asp Ser 
 2145                2150                2155                2160
Asp Val Pro Pro Glu Thr Glu Glu Cys Pro Ser Ile Thr Ala Asp Ala 
                 2165                2170                2175
Asn Ile Asp Ser Glu Asp Glu Ser Glu Thr Ile Pro Thr Asp Lys Thr 
             2180                2185                2190
Val Thr Tyr Lys His Met Asp Pro Pro Pro Ala Pro Val Gln Asp Arg 
         2195                2200                2205
Ser Pro Ser Pro Arg His Pro Asp Val Ser Met Val Asp Pro Glu Ala 
     2210                2215                2220
Leu Ala Ile Glu Gln Asn Leu Gly Lys Ala Leu Lys Lys Asp Leu Lys 
 2225                2230                2235                2240
Glu Lys Thr Lys Thr Lys Lys Pro Gly Thr Lys Thr Lys Ser Ser Ser 
                 2245                2250                2255
Pro Val Lys Lys Ser Asp Gly Lys Ser Lys Pro Leu Ala Ala Ser Pro 
             2260                2265                2270
Lys Pro Ala Gly Leu Lys Glu Ser Ser Asp Lys Val Ser Arg Val Ala 
         2275                2280                2285
Ser Pro Lys Lys Lys Glu Ser Val Glu Lys Ala Ala Lys Pro Thr Thr 
     2290                2295                2300
Thr Pro Glu Val Lys Ala Ala Arg Gly Glu Glu Lys Asp Lys Glu Thr 
 2305                2310                2315                2320
Lys Asn Ala Ala Asn Ala Ser Ala Ser Lys Ser Ala Lys Thr Ala Thr 
                 2325                2330                2335
Ala Gly Pro Gly Thr Thr Lys Thr Thr Lys Ser Ser Ala Val Pro Pro 
             2340                2345                2350
Gly Leu Pro Val Tyr Leu Asp Leu Cys Tyr Ile Pro Asn His Ser Asn 
         2355                2360                2365
Ser Lys Asn Val Asp Val Glu Phe Phe Lys Arg Val Arg Ser Ser Tyr 
     2370                2375                2380
Tyr Val Val Ser Gly Asn Asp Pro Ala Ala Glu Glu Pro Ser Arg Ala 
 2385                2390                2395                2400
Val Leu Asp Ala Leu Leu Glu Gly Lys Ala Gln Trp Gly Ser Asn Met 
                 2405                2410                2415
Gln Val Thr Leu Ile Pro Thr His Asp Ser Glu Val Met Arg Glu Trp 
             2420                2425                2430
Tyr Gln Glu Thr His Glu Lys Gln Gln Asp Leu Asn Ile Met Val Leu 
         2435                2440                2445
Ala Ser Ser Ser Thr Val Val Met Gln Asp Glu Ser Phe Pro Ala Cys 
     2450                2455                2460
Lys Ile Glu Leu 
 2465



<210> 8657
<211> 487
<212> DNA
<213> Rattus norvegicus
<308> U52950
<400> 8657

gcagagcag  ggagcggcg  gagaggaac  cttctccca  gctttagca  agccggcag  60
atggcgacc  tggtggtgg  agccaccga  ccggagcca  cgggcagca  cggcaaccc  120
gcggcgacc  cctcgccca  cctgtcgca  cgcttccta  acagcaagt  ctacttgct  180
gtggtggtc  gcgagacgg  gaccgaaga  cacctgagg  gtgccatcg  caacatcga  240
ctggggatc  gatcgtggg  gacaaacct  atcgagtgc  acttggacc  agagctcaa  300
cttttcgtg  ctcgacact  cgcgagatt  tctcctgaa  ttccaggac  aaagatcct  360
catcaccga  gtgacgtct  agaaactgt  gttctgatc  acccttcgg  tgaagcagt  420
agcaccgag  tgcgtttgg  gatcactga  gccgcccgc  ataaattgc  ggtgctctc  480
ggacagt  487



<210> 8658
<211> 2459
<212> PRT
<213> Rattus norvegicus
<308> CAC16162
<400> 8658

Met Ala Thr Val Val Val Glu Ala Thr Glu Pro Glu Pro Ser Gly Ser 
  1               5                  10                  15
Ile Gly Asn Pro Ala Ala Thr Thr Ser Pro Ser Leu Ser His Arg Phe 
             20                  25                  30
Leu Asp Ser Lys Phe Tyr Leu Leu Val Val Val Gly Glu Thr Val Thr 
         35                  40                  45
Glu Glu His Leu Arg Arg Ala Ile Gly Asn Ile Glu Leu Gly Ile Arg 
     50                  55                  60
Ser Trp Glu Thr Asn Leu Ile Glu Cys Asn Leu Asp Gln Glu Leu Lys 
 65                  70                  75                  80
Leu Phe Val Ser Arg His Ser Ala Arg Phe Ser Pro Glu Val Pro Gly 
                 85                  90                  95
Gln Lys Ile Leu His His Arg Ser Asp Val Leu Glu Thr Val Val Leu 
             100                105                110
Ile Asn Pro Ser Asp Glu Ala Val Ser Thr Glu Val Arg Leu Met Ile 
         115                120                125
Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln Cys Phe 
     130                135                140
Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser Phe Gln 
 145                150                155                160
Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu Leu Ser 
                 165                170                175
Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys Pro Glu 
             180                185                190
Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu Gln Asp 
         195                200                205
Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu Met Glu 
     210                215                220
Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu Val Pro 
 225                230                235                240
Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Lys 
                 245                250                255
Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly Asp Ser 
             260                265                270
Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly Gly Ser 
         275                280                285
Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp Arg Val 
     290                295                300
Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro Gly Ile 
 305                310                315                320
Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu Ser Gln 
                 325                330                335
Gly Ser Thr Ser Asn Ser Asp Trp Met Lys Asn Leu Ile Ser Pro Asp 
             340                345                350
Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys Asn Pro Glu 
         355                360                365
Pro Asn Ile Lys Met Lys Arg Ser Thr Glu Glu Ala Cys Phe Thr Leu 
     370                375                380
Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu Phe Arg Ser 
 385                390                395                400
Val Gly Asn Ala Ile Glu Pro Val Ile Leu Phe Gln Lys Met Gly Val 
                 405                410                415
Gly Lys Leu Lys Met Tyr Val Leu Asn Pro Val Lys Ser Ser Lys Glu 
             420                425                430
Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys Asp Lys Ala 
         435                440                445
Glu Leu Ile Leu Pro Asn Gly Gln Glu Val Asp Ile Pro Ile Ser Tyr 
     450                455                460
Leu Ala Ser Val Ser Ser Leu Ile Val Trp His Pro Ala Asn Pro Ala 
 465                470                475                480
Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr Gln Tyr Asn 
                 485                490                495
Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe Leu Lys Gln 
             500                505                510
Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Ser Thr Pro Pro 
         515                520                525
Val Lys Gln Val Lys Leu Lys Gln Arg Ala Asp Ser Arg Glu Ser Leu 
     530                535                540
Lys Pro Ala Thr Lys Pro Leu Ser Ser Lys Ser Val Arg Lys Glu Ser 
 545                550                555                560
Lys Glu Glu Ala Pro Glu Ala Thr Lys Ala Ser Gln Val Glu Lys Thr 
                 565                570                575
Pro Lys Val Glu Ser Lys Glu Lys Val Ile Val Lys Lys Asp Lys Pro 
             580                585                590
Gly Lys Val Glu Ser Lys Pro Ser Val Thr Glu Lys Glu Val Pro Ser 
         595                600                605
Lys Glu Glu Gln Ser Pro Val Lys Ala Glu Val Ala Glu Lys Ala Ala 
     610                615                620
Thr Glu Ser Lys Pro Lys Val Thr Lys Asp Lys Val Val Lys Lys Glu 
 625                630                635                640
Ile Lys Thr Lys Pro Glu Glu Lys Lys Glu Glu Lys Pro Lys Lys Glu 
                 645                650                655
Val Ala Lys Lys Glu Asp Lys Thr Pro Leu Lys Lys Asp Glu Lys Pro 
             660                665                670
Lys Lys Glu Glu Ala Lys Lys Glu Ile Lys Lys Glu Ile Lys Lys Glu 
         675                680                685
Glu Lys Lys Glu Leu Lys Lys Glu Val Lys Lys Glu Thr Pro Leu Lys 
     690                695                700
Asp Ala Lys Lys Glu Val Lys Lys Asp Glu Lys Lys Glu Val Lys Lys 
 705                710                715                720
Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys Ile Ser Lys Asp Ile 
                 725                730                735
Lys Lys Ser Thr Pro Leu Ser Asp Thr Lys Lys Pro Ala Ala Leu Lys 
             740                745                750
Pro Lys Val Ala Lys Lys Glu Glu Pro Thr Lys Lys Glu Pro Ile Ala 
         755                760                765
Ala Gly Lys Leu Lys Asp Lys Gly Lys Val Lys Val Ile Lys Lys Glu 
     770                775                780
Gly Lys Thr Thr Glu Ala Ala Ala Thr Ala Val Gly Thr Ala Ala Val 
 785                790                795                800
Ala Ala Ala Ala Gly Val Ala Ala Ser Gly Pro Ala Lys Glu Leu Glu 
                 805                810                815
Ala Glu Arg Ser Leu Met Ser Ser Pro Glu Asp Leu Thr Lys Asp Phe 
             820                825                830
Glu Glu Leu Lys Ala Glu Glu Ile Asp Val Ala Lys Asp Ile Lys Pro 
         835                840                845
Gln Leu Glu Leu Ile Glu Asp Glu Glu Lys Leu Lys Glu Thr Glu Pro 
     850                855                860
Gly Glu Ala Tyr Val Ile Gln Lys Glu Thr Glu Val Ser Lys Gly Ser 
 865                870                875                880
Ala Glu Ser Pro Asp Glu Gly Ile Thr Thr Thr Glu Gly Glu Gly Glu 
                 885                890                895
Cys Glu Gln Thr Pro Glu Glu Leu Glu Pro Val Glu Lys Gln Gly Val 
             900                905                910
Asp Asp Ile Glu Lys Phe Glu Asp Glu Gly Ala Gly Phe Glu Glu Ser 
         915                920                925
Ser Glu Ala Gly Asp Tyr Glu Glu Lys Ala Glu Thr Glu Glu Ala Glu 
     930                935                940
Glu Pro Glu Glu Asp Gly Glu Asp Asn Val Ser Gly Ser Ala Ser Lys 
 945                950                955                960
His Ser Pro Thr Glu Asp Glu Glu Ile Ala Lys Ala Glu Ala Asp Val 
                 965                970                975
His Ile Lys Glu Lys Arg Glu Ser Val Ala Ser Gly Asp Asp Arg Ala 
             980                985                990
Glu Glu Asp Met Asp Glu Ala Leu Glu Lys Gly Glu Ala Glu Gln Ser 
         995                1000                1005
Glu Glu Glu Gly Glu Glu Glu Glu Asp Lys Ala Glu Asp Ala Arg Glu 
     1010                1015                1020
Glu Asp His Glu Pro Asp Lys Thr Glu Ala Glu Asp Tyr Val Met Ala 
 1025                1030                1035                1040
Val Val Asp Lys Ala Ala Glu Ala Gly Val Thr Glu Asp Gln Tyr Asp 
                 1045                1050                1055
Phe Leu Gly Thr Pro Ala Lys Gln Pro Gly Val Gln Ser Pro Ser Arg 
             1060                1065                1070
Glu Pro Ala Ser Ser Ile His Asp Glu Thr Leu Pro Gly Gly Ser Glu 
         1075                1080                1085
Ser Glu Ala Thr Ala Ser Asp Glu Glu Asn Arg Glu Asp Gln Pro Glu 
     1090                1095                1100
Glu Phe Thr Ala Thr Ser Gly Tyr Thr Gln Ser Thr Ile Glu Ile Ser 
 1105                1110                1115                1120
Ser Glu Pro Thr Pro Met Asp Glu Met Ser Thr Pro Arg Asp Val Met 
                 1125                1130                1135
Thr Asp Glu Thr Asn Asn Glu Glu Thr Glu Ser Pro Ser Gln Glu Phe 
             1140                1145                1150
Val Asn Ile Thr Lys Tyr Glu Ser Ser Leu Tyr Ser Gln Glu Tyr Ser 
         1155                1160                1165
Lys Pro Val Val Ala Ser Phe Asn Gly Leu Ser Asp Gly Ser Lys Thr 
     1170                1175                1180
Asp Ala Thr Asp Gly Arg Asp Tyr Asn Ala Ser Ala Ser Thr Ile Ser 
 1185                1190                1195                1200
Pro Pro Ser Ser Met Glu Glu Asp Lys Phe Ser Lys Ser Ala Leu Arg 
                 1205                1210                1215
Asp Ala Tyr Arg Pro Glu Glu Thr Asp Val Lys Thr Gly Ala Glu Leu 
             1220                1225                1230
Asp Ile Lys Asp Val Ser Asp Glu Arg Leu Ser Pro Ala Lys Ser Pro 
         1235                1240                1245
Ser Leu Ser Pro Ser Pro Pro Ser Pro Ile Glu Lys Thr Pro Leu Gly 
     1250                1255                1260
Glu Arg Ser Val Asn Phe Ser Leu Thr Pro Asn Glu Ile Lys Ala Ser 
 1265                1270                1275                1280
Ala Glu Gly Glu Ala Thr Ala Val Val Ser Pro Gly Val Thr Gln Ala 
                 1285                1290                1295
Val Val Glu Glu His Cys Ala Ser Pro Glu Glu Lys Thr Leu Glu Val 
             1300                1305                1310
Val Ser Pro Ser Gln Ser Val Thr Gly Ser Ala Gly His Thr Pro Tyr 
         1315                1320                1325
Tyr Gln Ser Pro Thr Asp Glu Lys Ser Ser His Leu Pro Thr Glu Val 
     1330                1335                1340
Thr Glu Asn Ala Gln Ala Val Pro Val Ser Phe Glu Phe Thr Glu Ala 
 1345                1350                1355                1360
Lys Asp Glu Asn Glu Arg Ser Ser Ile Ser Pro Met Asp Glu Pro Val 
                 1365                1370                1375
Pro Asp Ser Glu Ser Pro Ile Glu Lys Val Leu Ser Pro Leu Arg Ser 
             1380                1385                1390
Pro Pro Leu Ile Gly Ser Glu Ser Ala Tyr Glu Asp Phe Leu Ser Ala 
         1395                1400                1405
Asp Asp Lys Ala Leu Gly Arg Arg Ser Glu Ser Pro Phe Glu Gly Lys 
     1410                1415                1420
Asn Gly Lys Gln Gly Phe Ser Asp Lys Glu Ser Pro Val Ser Asp Leu 
 1425                1430                1435                1440
Thr Ser Asp Leu Tyr Gln Asp Lys Gln Glu Glu Lys Arg Ala Gly Phe 
                 1445                1450                1455
Ile Pro Ile Lys Glu Asp Phe Ser Pro Glu Lys Lys Ala Ser Asp Ala 
             1460                1465                1470
Glu Ile Met Ser Ser Gln Ser Ala Leu Ala Leu Asp Glu Arg Lys Leu 
         1475                1480                1485
Gly Gly Asp Gly Ser Pro Thr Gln Val Asp Val Ser Gln Phe Gly Ser 
     1490                1495                1500
Phe Lys Glu Asp Thr Lys Met Ser Ile Ser Glu Gly Thr Val Ser Asp 
 1505                1510                1515                1520
Lys Ser Ala Thr Pro Val Asp Glu Gly Ala Glu Asp Thr Tyr Ser His 
                 1525                1530                1535
Met Glu Gly Val Ala Ser Val Ser Thr Ala Ser Val Ala Thr Ser Ser 
             1540                1545                1550
Phe Pro Glu Pro Thr Thr Asp Asp Val Ser Pro Ser Leu His Ala Glu 
         1555                1560                1565
Val Gly Ser Pro His Ser Thr Glu Val Asp Asp Ser Leu Ser Val Ser 
     1570                1575                1580
Val Val Gln Thr Pro Thr Thr Phe Gln Glu Thr Glu Met Ser Pro Ser 
 1585                1590                1595                1600
Lys Glu Glu Cys Pro Arg Pro Met Ser Ile Ser Pro Pro Asp Phe Ser 
                 1605                1610                1615
Pro Lys Thr Ala Lys Ser Arg Thr Pro Val Gln Asp His Arg Ser Glu 
             1620                1625                1630
Gln Ser Ser Met Ser Ile Glu Phe Gly Gln Glu Ser Pro Glu His Ser 
         1635                1640                1645
Leu Ala Met Asp Phe Ser Arg Gln Ser Pro Asp His Pro Thr Val Gly 
     1650                1655                1660
Ala Gly Met Leu His Ile Thr Glu Asn Gly Pro Thr Glu Val Asp Tyr 
 1665                1670                1675                1680
Ser Pro Ser Asp Ile Gln Asp Ser Ser Leu Ser His Lys Ile Pro Pro 
                 1685                1690                1695
Thr Glu Glu Pro Ser Tyr Thr Gln Asp Asn Asp Leu Ser Glu Leu Ile 
             1700                1705                1710
Ser Val Ser Gln Val Glu Ala Ser Pro Ser Thr Ser Ser Ala His Thr 
         1715                1720                1725
Pro Ser Gln Ile Ala Ser Pro Leu Gln Glu Asp Thr Leu Ser Asp Val 
     1730                1735                1740
Val Pro Pro Arg Asp Met Ser Leu Tyr Ala Ser Leu Ala Ser Glu Lys 
 1745                1750                1755                1760
Val Gln Ser Leu Glu Gly Glu Lys Leu Ser Pro Lys Ser Asp Ile Ser 
                 1765                1770                1775
Pro Leu Thr Pro Arg Glu Ser Ser Pro Thr Tyr Ser Pro Gly Phe Ser 
             1780                1785                1790
Asp Ser Thr Ser Gly Ala Lys Glu Ser Thr Ala Ala Tyr Gln Thr Ser 
         1795                1800                1805
Ser Ser Pro Pro Ile Asp Ala Ala Ala Ala Glu Pro Tyr Gly Phe Arg 
     1810                1815                1820
Ser Ser Met Leu Phe Asp Thr Met Gln His His Leu Ala Leu Ser Arg 
 1825                1830                1835                1840
Asp Leu Thr Thr Ser Ser Val Glu Lys Asp Asn Gly Gly Lys Thr Pro 
                 1845                1850                1855
Gly Asp Phe Asn Tyr Ala Tyr Gln Lys Pro Glu Ser Thr Thr Glu Ser 
             1860                1865                1870
Pro Asp Glu Glu Asp Tyr Asp Tyr Glu Ser His Glu Lys Thr Ile Gln 
         1875                1880                1885
Ala His Asp Val Gly Gly Tyr Tyr Tyr Glu Lys Thr Glu Arg Thr Ile 
     1890                1895                1900
Lys Ser Pro Cys Asp Ser Gly Tyr Ser Tyr Glu Thr Ile Glu Lys Thr 
 1905                1910                1915                1920
Thr Lys Thr Pro Glu Asp Gly Gly Tyr Ser Cys Glu Ile Thr Glu Lys 
                 1925                1930                1935
Thr Thr Arg Thr Pro Glu Glu Gly Gly Tyr Ser Tyr Glu Ile Ser Glu 
             1940                1945                1950
Lys Thr Thr Arg Thr Pro Glu Val Ser Gly Tyr Thr Tyr Glu Lys Thr 
         1955                1960                1965
Glu Arg Ser Arg Arg Leu Leu Asp Asp Ile Ser Asn Gly Tyr Asp Asp 
     1970                1975                1980
Thr Glu Asp Gly Gly His Thr Leu Gly Asp Cys Ser Tyr Ser Tyr Glu 
 1985                1990                1995                2000
Thr Thr Glu Lys Ile Thr Ser Phe Pro Glu Ser Glu Ser Tyr Ser Tyr 
                 2005                2010                2015
Glu Thr Thr Thr Lys Thr Thr Arg Ser Pro Asp Thr Ser Ala Tyr Cys 
             2020                2025                2030
Tyr Glu Thr Met Glu Lys Ile Thr Lys Thr Pro Gln Ala Ser Thr Tyr 
         2035                2040                2045
Ser Tyr Glu Thr Ser Asp Arg Cys Tyr Thr Pro Glu Arg Lys Ser Pro 
     2050                2055                2060
Ser Glu Ala Arg Gln Asp Val Asp Leu Cys Leu Val Ser Ser Cys Glu 
 2065                2070                2075                2080
Phe Lys His Pro Lys Thr Glu Leu Ser Pro Ser Phe Ile Asn Pro Asn 
                 2085                2090                2095
Pro Leu Glu Trp Phe Ala Gly Glu Glu Pro Thr Glu Glu Ser Glu Arg 
             2100                2105                2110
Pro Leu Thr Gln Ser Gly Gly Ala Pro Pro Pro Ser Gly Gly Lys Gln 
         2115                2120                2125
Gln Gly Arg Gln Cys Asp Glu Thr Pro Pro Thr Ser Val Ser Glu Ser 
     2130                2135                2140
Ala Pro Ser Gln Thr Asp Ser Asp Val Pro Pro Glu Thr Glu Glu Cys 
 2145                2150                2155                2160
Pro Ser Ile Thr Ala Asp Ala Asn Leu Asp Ser Glu Asp Glu Ser Glu 
                 2165                2170                2175
Thr Ile Pro Thr Asp Lys Thr Val Thr Tyr Lys His Met Asp Pro Pro 
             2180                2185                2190
Pro Ala Pro Met Gln Asp Arg Ser Pro Ser Pro Arg His Pro Asp Val 
         2195                2200                2205
Ser Met Val Asp Pro Glu Ala Leu Ala Ile Glu Gln Asn Leu Gly Lys 
     2210                2215                2220
Ala Leu Lys Lys Asp Leu Lys Glu Lys Ala Lys Thr Lys Lys Pro Gly 
 2225                2230                2235                2240
Thr Lys Thr Lys Ser Ser Ser Pro Val Lys Lys Gly Asp Gly Lys Ser 
                 2245                2250                2255
Lys Pro Ser Ala Ala Ser Pro Lys Pro Gly Ala Leu Lys Glu Ser Ser 
             2260                2265                2270
Asp Lys Val Ser Arg Val Ala Ser Pro Lys Lys Lys Glu Ser Val Glu 
         2275                2280                2285
Lys Ala Met Lys Thr Thr Thr Thr Pro Glu Val Lys Ala Thr Arg Gly 
     2290                2295                2300
Glu Glu Lys Asp Lys Glu Thr Lys Asn Ala Ala Asn Ala Ser Ala Ser 
 2305                2310                2315                2320
Lys Ser Val Lys Thr Ala Thr Ala Gly Pro Gly Thr Thr Lys Thr Ala 
                 2325                2330                2335
Lys Ser Ser Thr Val Pro Pro Gly Leu Pro Val Tyr Leu Asp Leu Cys 
             2340                2345                2350
Tyr Ile Pro Asn His Ser Asn Ser Lys Asn Val Asp Val Glu Phe Phe 
         2355                2360                2365
Lys Arg Val Arg Ser Ser Tyr Tyr Val Val Ser Gly Asn Asp Pro Ala 
     2370                2375                2380
Ala Glu Glu Pro Ser Arg Ala Val Leu Asp Ala Leu Leu Glu Gly Lys 
 2385                2390                2395                2400
Ala Gln Trp Gly Ser Asn Met Gln Val Thr Leu Ile Pro Thr His Asp 
                 2405                2410                2415
Ser Glu Val Met Arg Glu Trp Tyr Gln Glu Thr His Glu Lys Gln Gln 
             2420                2425                2430
Asp Leu Asn Ile Met Val Leu Ala Ser Ser Ser Thr Val Val Met Gln 
         2435                2440                2445
Asp Glu Ser Phe Pro Ala Cys Lys Ile Glu Leu 
     2450                2455



<210> 8659
<211> 9416
<212> DNA
<213> Homo sapiens
<308> L06237
<400> 8659

aagcgcgcc  cctccccgc  ctctctcac  ccccgctcc  ctccgccgc  cactctcgc  60
gcgctggga  agggcggag  gggaggcgg  gcgcggcgc  agaggaggg  ggacgcagg  120
ggcggagcg  agacagtac  ttcggagat  atcctttct  ctgccgcag  ggagaggag  180
ggccggagc  agacacttc  ccgaggcac  gcagccggc  ggatggcga  cgtggtggt  240
gaagccacc  agccggagc  gtccggcag  atcgccaac  cggcggcgt  cacctcgcc  300
agcctgtcg  accgcttcc  tgacagcaa  ttctacttg  tggtggtcg  cggcgagat  360
gtgaccgag  agcacctgc  gcgtgccat  ggcaacatc  agctcggaa  ccgatcatg  420
gacacaaac  tgattgaat  caacttgga  caagaactc  aactttttg  atctcgaca  480
tctgcaaga  tctctcctg  agtcccagg  caaaagatc  ttcatcacc  aagtgacgt  540
ttagaaaca  tggtcctga  caacccttc  gatgaagca  tcagcaccg  ggtgcgctt  600
atgatcact  atgctgccc  acacaagct  ctcgtgctg  ccgggcagt  ctttgaaaa  660
accggagag  tcattctcc  gtccggctc  ttctccttc  agaacttca  agagatttt  720
accgatcaa  agatcgggg  gttactaag  accacccat  ctgccaaca  agccagctt  780
accctgttc  gtcctgaag  aggggactg  aagaactcc  atcttgaca  acacaatct  840
caagacttc  tcaatatta  actcaattc  gcttctatc  tgccagaaa  ggaaggact  900
tctgagttt  ccgagtatc  ctcagaatc  gtggaagtc  catctccct  tgacatctt  960
gaacctccc  catcgggtg  atttctgaa  ctctccaag  cctgctgtt  tatttttcc  1020
ggagggagg  gcgattctg  cttgtttgc  gtgaatggt  tcaatatgc  catcaatgg  1080
ggatcagag  gaaaatcct  cttctggaa  ctcatccga  acttagacc  agtggactc  1140
atcctgctc  cccacattg  ggatgacaa  ttgcctgga  taaacagca  gttacagcg  1200
aaaattgca  agctcgagg  agaacagtc  cagggctcc  ccacaaata  tgactggat  1260
aaaaacctc  tctcccctg  cttaggagt  gtatttctc  atgtacctg  aaatctcaa  1320
aatccagag  caaacatca  gatgaagag  agcatagaa  aagcctgct  cactctcca  1380
tacctaaac  aattgtcca  gaaaccaga  cctctgttt  gaagtgtag  caatactat  1440
gatcctgtc  ttcttttcc  aaaaatggg  gtaggtaaa  ttgagatgt  tgtgcttaa  1500
ccagtcaag  gcagcaagg  aatgcagta  tttatgcag  agtggactg  taccaacaa  1560
gacaaggct  aattcattc  gcctaatgg  caagaagta  atctcccga  ttcctactt  1620
acttcagtc  catctttga  tgtgtggca  ccagcaaac  ctgcggaga  aatcatccg  1680
gtcctgttt  ctgggaaca  cacccagta  aacatcctg  aagggttgg  aaagctcaa  1740
catctagac  ttctgaagc  gccactggc  acccaaaag  atctcactg  ccaggtgcc  1800
actcctgtg  tgaaacaaa  aaaactgaa  cagagggct  atagccgag  aagtctgaa  1860
ccagccgca  aaccacttc  tagcaaatc  gtgcgcaag  agtcaaaag  agaaacccc  1920
gaggtcaca  aagtgaatc  cgtggaaaa  ccacccaaa  ttgaaagca  agaaaaggt  1980
atggtgaaa  aagacaagc  agtaaaaac  gagaccaaa  cttcagtga  tgaaaagga  2040
gttcccagc  aagaagagc  atctccagt  aaagccgag  tggctgaga  gcaagccac  2100
gatgtcaaa  ccaaagctg  caaggagaa  acggtgaaa  aggaaacaa  ggtaaagcc  2160
gaagacaag  aagaggaga  agaaaagcc  aagaaagaa  tggctaaaa  ggaggacaa  2220
acacctatc  agaaggagg  aaaaccaaa  aaggaagag  tgaaaaaag  agtcaaaaa  2280
gagatcaag  aagaagaga  aaaagaacc  aagaaagag  ttaagaaag  aacaccgcc  2340
aaggaagtc  agaaggaag  taagaagga  gagaagaag  aagtgaaaa  ggaagaaaa  2400
gaacccaaa  aagaaatta  gaagctccc  aaagacgca  agaaatcat  tactcctct  2460
tctgaagca  aaaaaccag  tgctttaaa  ccaaaagta  ccaagaagg  agagtctgt  2520
aagaaagat  ctgttgctg  cggaaagcc  aaggagaag  ggaaaataa  agtcattaa  2580
aaggaaggc  aggccgcag  ggctgtcgc  gcagctgtc  gcactggag  caccacagc  2640
gctgtcatg  cggcagctg  aatagcagc  attggccct  ccaaagaac  cgaagctga  2700
aggtccctt  tgtcatctc  tgaggatct  accaaggac  ttgaagagt  aaaggctga  2760
gaggtcgat  taacaaagg  catcaagcc  cagctggag  taatcgaag  cgaagagaa  2820
ctgaaggaa  ctgagccag  cgaagccta  gtcatccag  aggagagag  agtcaccaa  2880
ggtcctgcc  agtcccctg  tgagggaat  actaccact  aaggggagg  cgaatgtga  2940
cagacacct  aggagctgg  gcccgtcga  aagcaggga  tagacgaca  tgaaaaatt  3000
gaagatgaa  gagccggtt  tgaagaatc  tcagagact  gagactatg  agagaaggc  3060
gaaactgag  aggctgagg  gccagaaga  gatggggag  aacacgtat  tgtgagcgc  3120
tccaagcac  gccccactg  ggatgagga  agtgccaag  cggaggctg  tgcatacat  3180
agggagaag  gggagtctg  ggccagtgg  gatgaccga  ccgaagaag  catggatga  3240
gccattgag  aaggagagg  tgaacaatc  gaagaggag  ctgatgagg  ggacaaagc  3300
gaagatgcc  gagaggagg  atatgagcc  gaaaaaatg  aagctgaag  ctatgtgat  3360
gctgtggtc  acaaggctg  agaggctgg  ggtgccgag  agcagtatg  attcctcac  3420
acaccaacc  agcaactag  agcccagtc  cctggccga  aacctgcat  ttcaattca  3480
gatgagact  tacctggag  ctcagagag  gaggccacc  cttctgatg  ggagaatcg  3540
gaagaccag  ctgaggaat  cactgccac  tctggctac  ctcagtcta  tattgagat  3600
tccagtgag  ccaccccca  ggatgagat  tctacccct  gagacgtga  gagtgatga  3660
accaacaat  aagagacgg  gtccccttc  caggaattc  taaatatca  caaatatga  3720
tcttcattg  attctcagg  atactctaa  cctgctgat  ttacaccgc  caacggatt  3780
tctgaagga  caaaaacag  tgccactga  ggcaaggat  acaatgctt  agcctctac  3840
atatcacca  cctcttcca  ggaggaaga  aaattcagc  gatctgctt  acgtgatgc  3900
tactgctct  aagtgaaag  cagcaccac  ttggacatc  aagatagca  ctcagctgt  3960
tcaagtgaa  aggtcagcc  atcgaagag  ccgtccctg  gtccatctc  accatcacc  4020
ttagaaaag  cccccctgg  tgaacgtag  gtgaacttc  ctctgacgc  caatgagat  4080
aaagtctct  cagaggcag  agtagcccc  gtgtctcct  aggtgaccc  agaagtagt  4140
gaagaacat  gtgctagtc  tgaggacaa  actctggaa  tggtgtcac  atctcagtc  4200
gtgactggc  gtgctggtc  cacacctta  tatcaatct  ctactgacg  gaaatccag  4260
catctccct  cagaagtca  tgaaaaacc  ccagcagtt  cagtgagtt  tgaattcag  4320
gatgccaaa  atgagaatg  aagggcttc  gtaagcccc  tggatgagc  cgtgcctga  4380
tcagagtct  ctattgaaa  agttttgtc  cctttacgc  gcccgcccc  cattggatc  4440
gagtctgct  atgaaagtt  tctaagtgc  gatgacaag  cttctggca  aggtgccga  4500
agtcctttt  aagaaaaga  tggaaaaca  ggctctcca  accaagtaa  tccagtttc  4560
gaaatgact  ctactagtc  ttaccaaga  aaacaggaa  ggaaaagca  agactttgc  4620
ccaataaaa  aagactttg  ccaagaaaa  aaaactgat  atgttgaag  catgagttc  4680
caaccagca  tggctctgg  tgaaaggaa  ttaggagat  tttctccca  acaaataga  4740
gtcagtcag  ttggatctt  taaagaaga  actaagatg  ccatttctg  aggtactgt  4800
tcagacaag  cagctactc  tgttgatga  ggcgtagca  aagacacgt  ctctcatat  4860
gagggtgtg  cctcagtgt  cacagcctc  gtggctacg  gctcatttc  agagccaac  4920
acagatgat  tgtctccat  tctgcatgc  gaggttggc  ccccacatt  cacagaagt  4980
gatgactcc  tttcagtgt  tgttgtgca  acacctacc  cattccagg  aacagaaat  5040
tctccatct  aagaagaat  cccaagacc  atgtcaatt  ctccaccag  tttctcccc  5100
aaaactgca  agtccagga  acccgttca  gatcacaga  ctgaacagt  ctcaatgtc  5160
attgaattt  gccaagaat  tcctgagca  tcccttgct  tggacttca  tcgacagtc  5220
ccagatcac  ctacagtgg  tgcaggcgt  cttcacatc  ctgaaaatg  gccaactga  5280
gtggactac  gtccttctg  catgcagga  tccagttta  cacataaga  accacctat  5340
gaggagccg  cctacaccc  agataatga  ctttctgag  tcatctcag  atctcaggt  5400
gaggcctcc  cgtccacct  ttctgctca  accccttct  agatcgctt  tcctctcca  5460
gaagatact  tatccgatg  tgctcctcc  agagatatg  ccttatatg  ctcactcac  5520
tctgaaaaa  tgcaaagtc  ggaaggaga  aagctctct  caaaatctg  tatctctcc  5580
ctcacccca  gagagtcct  tcctttata  tcacctact  tttcagatt  tacctctgc  5640
gtcaaagag  aaacagcaa  ttgccacag  tcctcttct  caccaatag  tgcagcatc  5700
gcagagccc  atggcttcc  tgcctcagt  ttattcgat  caatgcaac  ccatctagc  5760
ttgaataga  atttgtcca  acctggcct  gagaaggac  gtggaggga  gacacctgg  5820
gactttagc  atgcctatc  aaagcctga  gaaacaacc  ggtccccag  tgaagaaga  5880
tatgactat  agtcttatg  gaagaccac  cggacctca  atgtgggtg  ctattacta  5940
gagaagata  agagaacca  aaaatctcc  agtgacagt  gctactcct  tgagaccat  6000
gggaaaact  ccaagaccc  tgaagatgg  gactattcc  atgaaatta  tgagaagac  6060
acacggacc  ctgaagagg  cgggtactc  tatgacata  gtgaaaaga  caccagccc  6120
cccgaagtg  gtggttaca  ctatgaaaa  actgagagg  ctagaaggc  tctggatga  6180
atcagcaat  gctatgatg  ctctgagga  ggtggccac  cacttgggg  ccccagcta  6240
tcttatgaa  ccactgaga  aattaccag  ttccctgag  ctgaaggtt  ttcctatga  6300
acatctaca  agacaacac  aacccctga  acttccaca  actgttacg  gactgcaga  6360
aaaatcact  gaacccctc  ggcatccac  tattcctac  agacttcag  cctatgcta  6420
actgcagaa  agaagtccc  ctcagaagc  cgtcaggat  tcgatttat  cctcgtgtc  6480
tcttgtgaa  acaagcacc  caagacaga  ctttcaccc  ctttcatta  tcccaatcc  6540
cttgagtgg  ttgccagtg  agaacccac  gaagaatct  aaaagcccc  cactcaatc  6600
gggggagcc  caccgcctc  aggaggaaa  caacagggc  gacagtgtg  tgaaacccc  6660
cccacctca  tcagcgagt  agccccatc  cagaccgac  ctgatgttc  cccggagac  6720
gaagagtgc  cctccatca  ggccgatgc  aatatcgac  ctgaagacg  gtcggaaac  6780
atccccaca  acaaaactg  cacgtacaa  cacatggac  cacctccag  tcccgtgca  6840
gaccgcagc  cttcgccac  ccaccctga  gtgtccatg  tggacccag  ggccttggc  6900
attgagcag  acctgggca  agctctaaa  aaagatctg  aagagaaga  caaaaccaa  6960
aagccaggt  caaagacca  gtcatcttc  cctgtcaaa  agagtgatg  gaagtctaa  7020
cccttggca  cttcaccaa  accagcggg  ttgaaagaa  cctcggata  agtgtccag  7080
gtggcttct  ctaagaaga  agaatctgt  gaaaaggca  caaaaccca  caccactcc  7140
gaggtcaaa  ctgcacgtg  ggaagagaa  gacaaggag  ccaagaatg  tgccaatgc  7200
tctgcatcc  agtcggcca  gaccgccac  gcaggacca  gaactacca  gacgaccaa  7260
tcatctgct  tgcccccag  cctccctgt  tatttggac  tgtgctaca  tcctaacca  7320
agcaatagt  agaatgttg  tgtggaatt  ttcaagaga  tgcggtctt  ctactacgt  7380
gtgagtggg  atgaccctg  tgctgagga  cccagccgg  ctgtcctgg  cgctttgtt  7440
gaaggaaag  ctcagtggg  cagcaacat  caggtgaca  tgatcccaa  tcatgactc  7500
gaagtgatg  gggaatggt  ccaggagac  catgagaaa  agcaagatc  caacatcat  7560
gttttagca  gcagcagca  agtggttat  caagatgaa  ccttccctg  atgcaagat  7620
gaactgtaa  aaccaaggc  agccacacc  caggatctg  actttgttt  cagaaattc  7680
tcaatttga  atcaccttt  ctaaaaagt  aattcatct  gttaagtcg  tgaacaatt  7740
cctgccaaa  gctatactg  gtcatggtg  tgcaagtca  taaatttct  agtttttgc  7800
gattgctaa  ggaaataac  gtatttcca  aatagggtt  aaattcctg  aaaattacc  7860
accccagtt  atctctgct  aacatttgg  aaccatgca  tagccaacc  aactgactt  7920
tgctaggta  aggcatttg  cttagagag  gagagagcg  gggagagag  gagagagag  7980
gagagcaca  agataacgc  ggagagaga  agagaaaga  tgagaaaga  aaggaatgc  8040
agagaagga  atgtaatga  agagagttc  ggtgagata  ccagagaga  aaagagaga  8100
cagggtggg  taaggagga  aaaataaac  aacaattag  tctgcattt  ctcaggcag  8160
aggcattct  tagtctaca  aggcaaagt  ttccatttt  gtcagtctg  gtcatcaaa  8220
agagtctta  ttttctaaa  caagttggc  agaagaaag  aaaaagaac  acacttgtt  8280
tgagggcat  tgatatttt  acatcttaa  taagctcct  cagtttgaa  gctgcacac  8340
gacataatg  agtgagtgt  gactggcca  gcaagtggt  tgggcccca  tcagaactc  8400
cagactcta  acacacaag  agattgatc  aaggcatgc  cccagcatt  gtccaccca  8460
ttagtccac  ctgagtcga  taacctgca  gcagcaaca  ccaagtcca  cccaattaa  8520
tgaagcaaa  accaaagca  ttgggagta  atatggtag  caatttgcc  taggaagtg  8580
cttgaatgt  caaagatac  tgatgcact  attttttaa  gtgagacag  aagtttata  8640
aacatccat  taggattat  gatacttaa  ggaacacgt  ggtgagcgt  tgtgggggt  8700
ctagaagct  atctgattg  tccaacagt  tgatgctga  tcatgcgtg  tgaatccca  8760
ttcagtgca  ctgtggcct  tcagtcaaa  aagttgtgc  tttcacagc  tctttacta  8820
tgcaagttc  agactgaaa  ggcttctat  atcagaact  ggaaaacag  gaatcttat  8880
gtggaagag  ttctcagca  gtgtacagt  tttaccttc  tttgtctta  attggcttt  8940
taaattttc  attaatttc  acataatta  gggaacaag  gtacagaag  atttttttt  9000
taagatatg  gagaacttt  catagatga  ctttttaac  aatgttttc  tttacagga  9060
attgcaaag  aaattctca  gtgatagtc  tttttttta  gtgtttcgt  agacaaaaa  9120
tgaataatg  tttttgaag  tctggcaag  ttgaagtct  atattgcag  aatgatatt  9180
attaaaaac  cataactac  aggaataat  atacctccc  ccccttgat  cccataaca  9240
aaaagtgct  cttgagagt  ggggagaat  gcatggtag  ctacttttc  gggccttga  9300
aagtacatc  cccagtggt  tcctacata  ttctttcaa  atcttcaac  atgaggtaa  9360
agagccaag  tcaaagaac  ctagcacaa  tttgctttg  gattttctt  tctgga  9416



<210> 8660
<211> 2468
<212> PRT
<213> Homo sapiens
<308> AAA18904
<400> 8660

Met Ala Thr Val Val Val Glu Ala Thr Glu Pro Glu Pro Ser Gly Ser 
  1               5                  10                  15
Ile Ala Asn Pro Ala Ala Ser Thr Ser Pro Ser Leu Ser His Arg Phe 
             20                  25                  30
Leu Asp Ser Lys Phe Tyr Leu Leu Val Val Val Gly Glu Ile Val Thr 
         35                  40                  45
Glu Glu His Leu Arg Arg Ala Ile Gly Asn Ile Glu Leu Gly Ile Arg 
     50                  55                  60
Ser Trp Asp Thr Asn Leu Ile Glu Cys Asn Leu Asp Gln Glu Leu Lys 
 65                  70                  75                  80
Leu Phe Val Ser Arg His Ser Ala Arg Phe Ser Pro Glu Val Pro Gly 
                 85                  90                  95
Gln Lys Ile Leu His His Arg Ser Asp Val Leu Glu Thr Val Val Leu 
             100                105                110
Ile Asn Pro Ser Asp Glu Ala Val Ser Thr Glu Val Arg Leu Met Ile 
         115                120                125
Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln Cys Phe 
     130                135                140
Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser Phe Gln 
 145                150                155                160
Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu Leu Ser 
                 165                170                175
Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys Pro Glu 
             180                185                190
Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu Gln Asp 
         195                200                205
Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu Met Glu 
     210                215                220
Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu Val Pro 
 225                230                235                240
Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Lys 
                 245                250                255
Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly Asp Ser 
             260                265                270
Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly Gly Ser 
         275                280                285
Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp Arg Val 
     290                295                300
Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro Gly Ile 
 305                310                315                320
Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu Gln Ser 
                 325                330                335
Gln Gly Ser Thr Thr Asn Ser Asp Trp Met Lys Asn Leu Ile Ser Pro 
             340                345                350
Asp Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys Asn Pro 
         355                360                365
Glu Pro Asn Ile Lys Met Lys Arg Ser Ile Glu Glu Ala Cys Phe Thr 
     370                375                380
Leu Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu Phe Arg 
 385                390                395                400
Ser Val Gly Asn Thr Ile Asp Pro Val Ile Leu Phe Gln Lys Met Gly 
                 405                410                415
Val Gly Lys Leu Glu Met Tyr Val Leu Asn Pro Val Lys Ser Ser Lys 
             420                425                430
Glu Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys Asp Lys 
         435                440                445
Ala Glu Phe Ile Leu Pro Asn Gly Gln Glu Val Asp Leu Pro Ile Ser 
     450                455                460
Tyr Leu Thr Ser Val Ser Ser Leu Ile Val Trp His Pro Ala Asn Pro 
 465                470                475                480
Ala Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr Gln Tyr 
                 485                490                495
Asn Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe Leu Lys 
             500                505                510
Gln Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Pro Thr Pro 
         515                520                525
Val Val Lys Gln Thr Lys Leu Lys Gln Arg Ala Asp Ser Arg Glu Ser 
     530                535                540
Leu Lys Pro Ala Ala Lys Pro Leu Pro Ser Lys Ser Val Arg Lys Glu 
 545                550                555                560
Ser Lys Glu Glu Thr Pro Glu Val Thr Lys Val Asn His Val Glu Lys 
                 565                570                575
Pro Pro Lys Val Glu Ser Lys Glu Lys Val Met Val Lys Lys Asp Lys 
             580                585                590
Pro Val Lys Thr Glu Thr Lys Pro Ser Val Thr Glu Lys Glu Val Pro 
         595                600                605
Ser Lys Glu Glu Pro Ser Pro Val Lys Ala Glu Val Ala Glu Lys Gln 
     610                615                620
Ala Thr Asp Val Lys Pro Lys Ala Ala Lys Glu Lys Thr Val Lys Lys 
 625                630                635                640
Glu Thr Lys Val Lys Pro Glu Asp Lys Lys Glu Glu Lys Glu Lys Pro 
                 645                650                655
Lys Lys Glu Val Ala Lys Lys Glu Asp Lys Thr Pro Ile Lys Lys Glu 
             660                665                670
Glu Lys Pro Lys Lys Glu Glu Val Lys Lys Glu Val Lys Lys Glu Ile 
         675                680                685
Lys Lys Glu Glu Lys Lys Glu Pro Lys Lys Glu Val Lys Lys Glu Thr 
     690                695                700
Pro Pro Lys Glu Val Lys Lys Glu Val Lys Lys Glu Glu Lys Lys Glu 
 705                710                715                720
Val Lys Lys Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys Leu Pro 
                 725                730                735
Lys Asp Ala Lys Lys Ser Ser Thr Pro Leu Ser Glu Ala Lys Lys Pro 
             740                745                750
Ala Ala Leu Lys Pro Lys Val Pro Lys Lys Glu Glu Ser Val Lys Lys 
         755                760                765
Asp Ser Val Ala Ala Gly Lys Pro Lys Glu Lys Gly Lys Ile Lys Val 
     770                775                780
Ile Lys Lys Glu Gly Lys Ala Ala Glu Ala Val Ala Ala Ala Val Gly 
 785                790                795                800
Thr Gly Ala Thr Thr Ala Ala Val Met Ala Ala Ala Gly Ile Ala Ala 
                 805                810                815
Ile Gly Pro Ala Lys Glu Leu Glu Ala Glu Arg Ser Leu Met Ser Ser 
             820                825                830
Pro Glu Asp Leu Thr Lys Asp Phe Glu Glu Leu Lys Ala Glu Glu Val 
         835                840                845
Asp Val Thr Lys Asp Ile Lys Pro Gln Leu Glu Leu Ile Glu Asp Glu 
     850                855                860
Glu Lys Leu Lys Glu Thr Glu Pro Val Glu Ala Tyr Val Ile Gln Lys 
 865                870                875                880
Glu Arg Glu Val Thr Lys Gly Pro Ala Glu Ser Pro Asp Glu Gly Ile 
                 885                890                895
Thr Thr Thr Glu Gly Glu Gly Glu Cys Glu Gln Thr Pro Glu Glu Leu 
             900                905                910
Glu Pro Val Glu Lys Gln Gly Val Asp Asp Ile Glu Lys Phe Glu Asp 
         915                920                925
Glu Gly Ala Gly Phe Glu Glu Ser Ser Glu Thr Gly Asp Tyr Glu Glu 
     930                935                940
Lys Ala Glu Thr Glu Glu Ala Glu Glu Pro Glu Glu Asp Gly Glu Glu 
 945                950                955                960
His Val Cys Val Ser Ala Ser Lys His Ser Pro Thr Glu Asp Glu Glu 
                 965                970                975
Ser Ala Lys Ala Glu Ala Asp Ala Tyr Ile Arg Glu Lys Arg Glu Ser 
             980                985                990
Val Ala Ser Gly Asp Asp Arg Ala Glu Glu Asp Met Asp Glu Ala Ile 
         995                1000                1005
Glu Lys Gly Glu Ala Glu Gln Ser Glu Glu Glu Ala Asp Glu Glu Asp 
     1010                1015                1020
Lys Ala Glu Asp Ala Arg Glu Glu Glu Tyr Glu Pro Glu Lys Met Glu 
 1025                1030                1035                1040
Ala Glu Asp Tyr Val Met Ala Val Val Asp Lys Ala Ala Glu Ala Gly 
                 1045                1050                1055
Gly Ala Glu Glu Gln Tyr Gly Phe Leu Thr Thr Pro Thr Lys Gln Leu 
             1060                1065                1070
Gly Ala Gln Ser Pro Gly Arg Glu Pro Ala Ser Ser Ile His Asp Glu 
         1075                1080                1085
Thr Leu Pro Gly Gly Ser Glu Ser Glu Ala Thr Ala Ser Asp Glu Glu 
     1090                1095                1100
Asn Arg Glu Asp Gln Pro Glu Glu Phe Thr Ala Thr Ser Gly Tyr Thr 
 1105                1110                1115                1120
Gln Ser Thr Ile Glu Ile Ser Ser Glu Pro Thr Pro Met Asp Glu Met 
                 1125                1130                1135
Ser Thr Pro Arg Asp Val Met Ser Asp Glu Thr Asn Asn Glu Glu Thr 
             1140                1145                1150
Glu Ser Pro Ser Gln Glu Phe Val Asn Ile Thr Lys Tyr Glu Ser Ser 
         1155                1160                1165
Leu Tyr Ser Gln Glu Tyr Ser Lys Pro Ala Asp Val Thr Pro Leu Asn 
     1170                1175                1180
Gly Phe Ser Glu Gly Ser Lys Thr Asp Ala Thr Asp Gly Lys Asp Tyr 
 1185                1190                1195                1200
Asn Ala Ser Ala Ser Thr Ile Ser Pro Pro Ser Ser Met Glu Glu Asp 
                 1205                1210                1215
Lys Phe Ser Arg Ser Ala Leu Arg Asp Ala Tyr Cys Ser Glu Val Lys 
             1220                1225                1230
Ala Ser Thr Thr Leu Asp Ile Lys Asp Ser Ile Ser Ala Val Ser Ser 
         1235                1240                1245
Glu Lys Val Ser Pro Ser Lys Ser Pro Ser Leu Ser Pro Ser Pro Pro 
     1250                1255                1260
Ser Pro Leu Glu Lys Thr Pro Leu Gly Glu Arg Ser Val Asn Phe Ser 
 1265                1270                1275                1280
Leu Thr Pro Asn Glu Ile Lys Val Ser Ala Glu Ala Glu Val Ala Pro 
                 1285                1290                1295
Val Ser Pro Glu Val Thr Gln Glu Val Val Glu Glu His Cys Ala Ser 
             1300                1305                1310
Pro Glu Asp Lys Thr Leu Glu Val Val Ser Pro Ser Gln Ser Val Thr 
         1315                1320                1325
Gly Ser Ala Gly His Thr Pro Tyr Tyr Gln Ser Pro Thr Asp Glu Lys 
     1330                1335                1340
Ser Ser His Leu Pro Thr Glu Val Ile Glu Lys Pro Pro Ala Val Pro 
 1345                1350                1355                1360
Val Ser Phe Glu Phe Ser Asp Ala Lys Asp Glu Asn Glu Arg Ala Ser 
                 1365                1370                1375
Val Ser Pro Met Asp Glu Pro Val Pro Asp Ser Glu Ser Pro Ile Glu 
             1380                1385                1390
Lys Val Leu Ser Pro Leu Arg Ser Pro Pro Leu Ile Gly Ser Glu Ser 
         1395                1400                1405
Ala Tyr Glu Ser Phe Leu Ser Ala Asp Asp Lys Ala Ser Gly Arg Gly 
     1410                1415                1420
Ala Glu Ser Pro Phe Glu Glu Lys Ser Gly Lys Gln Gly Ser Pro Asp 
 1425                1430                1435                1440
Gln Val Ser Pro Val Ser Glu Met Thr Ser Thr Ser Leu Tyr Gln Asp 
                 1445                1450                1455
Lys Gln Glu Gly Lys Ser Thr Asp Phe Ala Pro Ile Lys Glu Asp Phe 
             1460                1465                1470
Gly Gln Glu Lys Lys Thr Asp Asp Val Glu Ala Met Ser Ser Gln Pro 
         1475                1480                1485
Ala Leu Ala Leu Asp Glu Arg Lys Leu Gly Asp Val Ser Pro Thr Gln 
     1490                1495                1500
Ile Asp Val Ser Gln Phe Gly Ser Phe Lys Glu Asp Thr Lys Met Ser 
 1505                1510                1515                1520
Ile Ser Glu Gly Thr Val Ser Asp Lys Ser Ala Thr Pro Val Asp Glu 
                 1525                1530                1535
Gly Val Ala Glu Asp Thr Tyr Ser His Met Glu Gly Val Ala Ser Val 
             1540                1545                1550
Ser Thr Ala Ser Val Ala Thr Ser Ser Phe Pro Glu Pro Thr Thr Asp 
         1555                1560                1565
Asp Val Ser Pro Ser Leu His Ala Glu Val Gly Ser Pro His Ser Thr 
     1570                1575                1580
Glu Val Asp Asp Ser Leu Ser Val Ser Val Val Gln Thr Pro Thr Thr 
 1585                1590                1595                1600
Phe Gln Glu Thr Glu Met Ser Pro Ser Lys Glu Glu Cys Pro Arg Pro 
                 1605                1610                1615
Met Ser Ile Ser Pro Pro Asp Phe Ser Pro Lys Thr Ala Lys Ser Arg 
             1620                1625                1630
Thr Pro Val Gln Asp His Arg Ser Glu Gln Ser Ser Met Ser Ile Glu 
         1635                1640                1645
Phe Gly Gln Glu Ser Pro Glu Gln Ser Leu Ala Met Asp Phe Ser Arg 
     1650                1655                1660
Gln Ser Pro Asp His Pro Thr Val Gly Ala Gly Val Leu His Ile Thr 
 1665                1670                1675                1680
Glu Asn Gly Pro Thr Glu Val Asp Tyr Ser Pro Ser Asp Met Gln Asp 
                 1685                1690                1695
Ser Ser Leu Ser His Lys Ile Pro Pro Met Glu Glu Pro Ser Tyr Thr 
             1700                1705                1710
Gln Asp Asn Asp Leu Ser Glu Leu Ile Ser Val Ser Gln Val Glu Ala 
         1715                1720                1725
Ser Pro Ser Thr Ser Ser Ala His Thr Pro Ser Gln Ile Ala Ser Pro 
     1730                1735                1740
Leu Gln Glu Asp Thr Leu Ser Asp Val Ala Pro Pro Arg Asp Met Ser 
 1745                1750                1755                1760
Leu Tyr Ala Ser Leu Thr Ser Glu Lys Val Gln Ser Leu Glu Gly Glu 
                 1765                1770                1775
Lys Leu Ser Pro Lys Ser Asp Ile Ser Pro Leu Thr Pro Arg Glu Ser 
             1780                1785                1790
Ser Pro Leu Tyr Ser Pro Thr Phe Ser Asp Ser Thr Ser Ala Val Lys 
         1795                1800                1805
Glu Lys Thr Ala Thr Cys His Ser Ser Ser Ser Pro Pro Ile Asp Ala 
     1810                1815                1820
Ala Ser Ala Glu Pro Tyr Gly Phe Arg Ala Ser Val Leu Phe Asp Thr 
 1825                1830                1835                1840
Met Gln His His Leu Ala Leu Asn Arg Asp Leu Ser Thr Pro Gly Leu 
                 1845                1850                1855
Glu Lys Asp Ser Gly Gly Lys Thr Pro Gly Asp Phe Ser Tyr Ala Tyr 
             1860                1865                1870
Gln Lys Pro Glu Glu Thr Thr Arg Ser Pro Asp Glu Glu Asp Tyr Asp 
         1875                1880                1885
Tyr Glu Ser Tyr Glu Lys Thr Thr Arg Thr Ser Asp Val Gly Gly Tyr 
     1890                1895                1900
Tyr Tyr Glu Lys Ile Glu Arg Thr Thr Lys Ser Pro Ser Asp Ser Gly 
 1905                1910                1915                1920
Tyr Ser Tyr Glu Thr Ile Gly Lys Thr Thr Lys Thr Pro Glu Asp Gly 
                 1925                1930                1935
Asp Tyr Ser Tyr Glu Ile Ile Glu Lys Thr Thr Arg Thr Pro Glu Glu 
             1940                1945                1950
Gly Gly Tyr Ser Tyr Asp Ile Ser Glu Lys Thr Thr Ser Pro Pro Glu 
         1955                1960                1965
Val Ser Gly Tyr Ser Tyr Glu Lys Thr Glu Arg Ser Arg Arg Leu Leu 
     1970                1975                1980
Asp Asp Ile Ser Asn Gly Tyr Asp Asp Ser Glu Asp Gly Gly His Thr 
 1985                1990                1995                2000
Leu Gly Asp Pro Ser Tyr Ser Tyr Glu Thr Thr Glu Lys Ile Thr Ser 
                 2005                2010                2015
Phe Pro Glu Ser Glu Gly Tyr Ser Tyr Glu Thr Ser Thr Lys Thr Thr 
             2020                2025                2030
Arg Thr Pro Asp Thr Ser Thr Tyr Cys Tyr Glu Thr Ala Glu Lys Ile 
         2035                2040                2045
Thr Arg Thr Pro Gln Ala Ser Thr Tyr Ser Tyr Glu Thr Ser Asp Leu 
     2050                2055                2060
Cys Tyr Thr Ala Glu Lys Lys Ser Pro Ser Glu Ala Arg Gln Asp Val 
 2065                2070                2075                2080
Asp Leu Cys Leu Val Ser Ser Cys Glu Tyr Lys His Pro Lys Thr Glu 
                 2085                2090                2095
Leu Ser Pro Ser Phe Ile Asn Pro Asn Pro Leu Glu Trp Phe Ala Ser 
             2100                2105                2110
Glu Glu Pro Thr Glu Glu Ser Glu Lys Pro Leu Thr Gln Ser Gly Gly 
         2115                2120                2125
Ala Pro Pro Pro Pro Gly Gly Lys Gln Gln Gly Arg Gln Cys Asp Glu 
     2130                2135                2140
Thr Pro Pro Thr Ser Val Ser Glu Ser Ala Pro Ser Gln Thr Asp Ser 
 2145                2150                2155                2160
Asp Val Pro Pro Glu Thr Glu Glu Cys Pro Ser Ile Thr Ala Asp Ala 
                 2165                2170                2175
Asn Ile Asp Ser Glu Asp Glu Ser Glu Thr Ile Pro Thr Asp Lys Thr 
             2180                2185                2190
Val Thr Tyr Lys His Met Asp Pro Pro Pro Ala Pro Val Gln Asp Arg 
         2195                2200                2205
Ser Pro Ser Pro Arg His Pro Asp Val Ser Met Val Asp Pro Glu Ala 
     2210                2215                2220
Leu Ala Ile Glu Gln Asn Leu Gly Lys Ala Leu Lys Lys Asp Leu Lys 
 2225                2230                2235                2240
Glu Lys Thr Lys Thr Lys Lys Pro Gly Thr Lys Thr Lys Ser Ser Ser 
                 2245                2250                2255
Pro Val Lys Lys Ser Asp Gly Lys Ser Lys Pro Leu Ala Ala Ser Pro 
             2260                2265                2270
Lys Pro Ala Gly Leu Lys Glu Ser Ser Asp Lys Val Ser Arg Val Ala 
         2275                2280                2285
Ser Pro Lys Lys Lys Glu Ser Val Glu Lys Ala Ala Lys Pro Thr Thr 
     2290                2295                2300
Thr Pro Glu Val Lys Ala Ala Arg Gly Glu Glu Lys Asp Lys Glu Thr 
 2305                2310                2315                2320
Lys Asn Ala Ala Asn Ala Ser Ala Ser Lys Ser Ala Lys Thr Ala Thr 
                 2325                2330                2335
Ala Gly Pro Gly Thr Thr Lys Thr Thr Lys Ser Ser Ala Val Pro Pro 
             2340                2345                2350
Gly Leu Pro Val Tyr Leu Asp Leu Cys Tyr Ile Pro Asn His Ser Asn 
         2355                2360                2365
Ser Lys Asn Val Asp Val Glu Phe Phe Lys Arg Val Arg Ser Ser Tyr 
     2370                2375                2380
Tyr Val Val Ser Gly Asn Asp Pro Ala Ala Glu Glu Pro Ser Arg Ala 
 2385                2390                2395                2400
Val Leu Asp Ala Leu Leu Glu Gly Lys Ala Gln Trp Gly Ser Asn Met 
                 2405                2410                2415
Gln Val Thr Leu Ile Pro Thr His Asp Ser Glu Val Met Arg Glu Trp 
             2420                2425                2430
Tyr Gln Glu Thr His Glu Lys Gln Gln Asp Leu Asn Ile Met Val Leu 
         2435                2440                2445
Ala Ser Ser Ser Thr Val Val Met Gln Asp Glu Ser Phe Pro Ala Cys 
     2450                2455                2460
Lys Ile Glu Leu 
 2465



<210> 8661
<211> 2006
<212> DNA
<213> Rattus norvegicus
<308> U53184
<400> 8661

gcgcgcgcg  ccagcgaga  ctcccggct  cactggcgg  gcgggcggc  gtaaaatgt  60
ggctccagg  ccttaccaa  cagctgcag  cccttctgt  atgcctact  cacccccaa  120
ctatgaaga  acagtgggt  tcaacagtt  ctacccaac  cccccagca  ctcagccgg  180
accagccac  gggctcatt  cgggcccgg  tgggaaggg  atgaatcca  cttcgtact  240
cacccagcc  gtgcctgtc  ccaacgcca  cgcaattgc  gtgcagacg  tttatgtgc  300
gcagcccat  tccttctac  accgcccca  ccagatgtg  tgtccttcc  gcaacaaga  360
gatcgtgac  cagttgtcc  acaatgcag  agccctcac  tggctctcc  gtggcagtc  420
gtgtctgct  ggatgcgtc  ctggctgct  cttcattcc  ttttgcgtg  acgccctgc  480
ggatgtgga  cattactgc  ccaactgca  agcgctcct  ggcacctac  aacgtttgt  540
ggactcggc  agccacagg  gaggtagac  agtgctccc  gaagtcacc  aacccttgc  600
cagcgcagc  agaagacgt  ccttccttg  tctcttcat  agctcgtct  cgtgtcttt  660
agggggtgg  gaaagtcgg  aaagtaaca  acccccaaa  ccagaaact  ctgctggag  720
tgtgccctg  acatgcaaa  acgtggacc  tgggtgttg  tttaagggt  taccgcctg  780
tctcgttac  ccactaact  tgattgtta  tccatttgc  tctcgtctg  tgatttgcc  840
ctgcctgcc  cctcttcct  aagaagagg  cttcctggt  ccaggctca  aacccgaag  900
tacagtttg  cttattttt  actgtttgg  ttgatctgt  ccatctctc  cagccctaa  960
gacagagac  ttgccttaa  gactttgcg  ttctgtaat  gcagacttc  ccagcactc  1020
gaatcactt  caattccat  gagttgttc  tctccacac  cacccctcc  ccggtgcac  1080
gaagggctg  cgacaccca  cagactcat  cagagaagg  cacaagtac  aaatgaaag  1140
ctcccagcc  accttgtct  agcccctgt  ctgtgaagg  actccttcc  cacacagtt  1200
ctgtgactt  cttttgttc  taaacacat  gaagttact  ggcagggag  catttctag  1260
ataattttt  tgatcacga  acacccttc  ttctccgtt  gctggtatg  ttttagttg  1320
tttggtttt  gttttccac  tacagtcta  ctcgtggcc  gccttgagc  ccgaggaga  1380
cctccatct  ctcctctca  atacccagg  cccagacat  tgcctctgc  cctgctggg  1440
tttttctct  atttttcct  aaccagaaa  acaaacggg  aatttcatc  actgcctat  1500
taggtttgg  gtggttttg  aaaccttgt  tccatgggg  cctttgggg  agtcagggg  1560
cccctgcac  agcccatgc  tcaatgccg  gagattggc  gctggaacc  cctgaagca  1620
gatttcatg  tttagagat  agcttctgt  gtacggtca  catggtctc  aacatcaac  1680
gacaaggta  aaggatgtc  acgacaaag  taagttcag  gctctttct  gggtcacca  1740
tctgtcctg  gtaacactg  cacagtctg  ccagccttt  aggaggtcc  ggctccctc  1800
taaacccat  taggwcttg  tgcaagtaa  agtgtatga  gtcaacctg  cctggaaca  1860
aagtctgca  attggttaa  atacagcct  tgtatcttc  tacaacgat  cagaagtac  1920
agacatcat  tttgcagtg  attatgggt  ccatacatg  ctttgatga  atctgcttt  1980
aaacaaata  aatctttga  cactca  2006



<210> 8662
<211> 2368
<212> DNA
<213> Homo sapiens
<308> AB034747
<400> 8662

gtttctctc  ctgcccccg  gacttcgcg  aagatccgg  aaggacacc  gaggcccct  60
ggagaccct  gggaggtga  agtcagaga  cgaagcggg  cgtggcccc  aggcctgac  120
cctccccgc  gggtaaggc  ggcaccccg  gagcgcagg  gtcctctta  tgctgatgg  180
acccagctc  gggcccaga  gccgctcac  gtccaccgc  ggtgctggg  aaaatgtcg  240
ttccaggac  ttaccaggc  gccactggg  cttcctcag  accatccgc  cctccatcc  300
atgaagaga  agtggctgt  aacagttat  accccacac  tccagctcc  atgcctggg  360
caactacgg  gcttgtgac  gggcctgat  ggaagggca  gaatcctcc  tcgtattat  420
cccagccag  gcccatccc  aataacaat  caattaccg  gcagacggt  tacgtgcag  480
accccatca  ctttttgga  cgccctatc  aaatgtgtt  tccttcctg  aacaagatg  540
tcgtgagtc  gctgtccta  aacgccggt  ctctgacct  gctgtcctg  gggagcctg  600
gcctgctgg  gtgcatagc  ggctgctgc  tcatcccct  ctgcgtgga  gccctgcag  660
acgtggacc  ttactgtcc  aactgcaga  ctctcctgg  cacctacaa  cgtttgtag  720
actcagcca  acgtggagg  agccgggtg  cgcaggaag  cctttccac  tctcatcca  780
cttcacgcc  ggtggaggt  ctgccctgg  ggtctcacc  ctccagggg  cccaccttc  840
tgtcttctt  tggggggaa  acgtcgcaa  actaacaaa  ctccaaacc  cagaaattg  900
tgcttggag  cgtgcatag  acttgcaaa  acattcccc  tgagtgtca  ttccacggt  960
tcctgcctc  ctgagaccc  gagtcctgc  atctaactg  gatcattgc  ctatccgaa  1020
atcttcctg  gatctgcca  cagtggctc  tttttcctg  ttccatggg  ctttctggt  1080
gcagtctca  actgagaag  cacagttgc  ttatttttg  ggctgttct  cccagagct  1140
ggctgaacc  gcctttagt  cctaccatt  tcttatccg  ctcttcccg  ccctgatga  1200
aaagatctt  ccttacaga  tttacaggc  tggctttga  attctgtaa  tgcagactt  1260
attagcaca  agattcact  taatttctt  atttttttt  taaatacaa  gagggggct  1320
ttaacaccc  gtacagaca  atccacaag  tcgtaaatg  atgctagaa  aatagggct  1380
gatcttatc  ctgccctgt  tccccttgt  tctctgtgc  agatcttca  tgccccttt  1440
catacaggg  tttttttct  atagagtaa  tatatgaac  gtttttatg  cctcctttt  1500
gtctgaaat  cttttgaac  gaatttctt  tttttaaaa  aaaacagag  tggggtctt  1560
ctatgttgc  caggctggt  tcgaactcc  gggctcaag  gatccttct  ccttggcct  1620
ccgaagtgc  gggattgca  gcataagct  ccatgctgg  cctgaacat  atttcaaga  1680
gaggattta  aaaaccatt  tctgtaatc  aatgattgg  gtcattttc  catttgcca  1740
tgtagtctc  cttaaaaaa  aaaaaaaga  aaagaaatg  ataatttca  ctactgcct  1800
tacttgggg  taatgtgat  cttaaacac  ttcatcatg  aactctcag  gtggggtcc  1860
ttttggttt  ctggtggtg  gttttgaaa  ataagggaa  gcacatttt  agcatgtct  1920
ggtaccatg  tgcggatgc  tgggaacca  aactgtttc  gaggaatct  aagtctgat  1980
ttagttttc  gagacacag  ttgttgtaa  acatgagaa  acatgattt  taggactca  2040
gcagcaagc  aggattcta  gttggctgc  gtgtcatct  tgaagtcaa  acaaagctg  2100
gctcgacct  caagggtcc  cgttttgat  atacttcag  atagggaac  catgtgaat  2160
ctactatgt  gaaataaaa  ctagacctt  agcgaacat  tgtatattg  ttgaaaacg  2220
tagtggtaa  cattgatcc  ccttcattt  atgtttgga  aattccagt  attatcatt  2280
ttgcaacga  tatggatac  acatagtac  ttggtgtta  ctgcttttg  aaaataaag  2340
ctttggttc  cccggtaaa  aaaaaaaa  2368



<210> 8663
<211> 228
<212> PRT
<213> Homo sapiens
<308> Q99732
<400> 8663

Met Ser Val Pro Gly Pro Tyr Gln Ala Ala Thr Gly Pro Ser Ser Ala 
  1               5                  10                  15
Pro Ser Ala Pro Pro Ser Tyr Glu Glu Thr Val Ala Val Asn Ser Tyr 
             20                  25                  30
Tyr Pro Thr Pro Pro Ala Pro Met Pro Gly Pro Thr Thr Gly Leu Val 
         35                  40                  45
Thr Gly Pro Asp Gly Lys Gly Met Asn Pro Pro Ser Tyr Tyr Thr Gln 
     50                  55                  60
Pro Ala Pro Ile Pro Asn Asn Asn Pro Ile Thr Val Gln Thr Val Tyr 
 65                  70                  75                  80
Val Gln His Pro Ile Thr Phe Leu Asp Arg Pro Ile Gln Met Cys Cys 
                 85                  90                  95
Pro Ser Cys Asn Lys Met Ile Val Ser Gln Leu Ser Tyr Asn Ala Gly 
             100                105                110
Ala Leu Thr Trp Leu Ser Cys Gly Ser Leu Cys Leu Leu Gly Val His 
         115                120                125
Ser Gly Leu Leu Leu His Pro Leu Leu Arg Gly Cys Pro Ala Gly Arg 
     130                135                140
Gly Pro Leu Leu Ser Gln Leu Gln Ser Ser Pro Gly His Leu Gln Ala 
 145                150                155                160
Phe Val Gly Leu Ser Gln Thr Trp Arg Glu Pro Gly Ala Ala Gly Ser 
                 165                170                175
Pro Phe His Leu Ser Ser Ser Phe Thr Pro Gly Gly Gly Ser Ala Leu 
             180                185                190
Val Val Ser Pro Leu Gln Gly Ala His Leu His Val Phe Phe Trp Gly 
         195                200                205
Glu Tyr Val Ala Lys Leu Thr Asn Leu Gln Thr Pro Glu Ile Ala Ala 
     210                215                220
Trp Ser Arg Ala 
 225



<210> 8664
<211> 2044
<212> DNA
<213> Rattus norvegicus
<308> NM_030999
<400> 8664

ctaggtgct  ctcaaccag  cctagtgac  ggcnccact  cgccagcgc  tctcagagc  60
ctnnntcac  gggtacnag  acctcgtct  ggtgctgga  aaggtgagt  ggcctgggt  120
tcgccgccc  gcagcctca  tttctatgc  tgggtctcc  gaccgctca  ggctgatat  180
gaccttctg  gccacaagc  gggttagct  cggcggncg  caccgctgc  nnnnnnctc  240
cgcactgcc  caagccggg  tgcggggag  cgaggttca  cacggccag  gtgcgggga  300
ccggcccgg  tttgggcag  ggaccgagg  ggcgggagc  nncagccag  ggaggggcg  360
ggagcggag  agggaccgc  ggggagagg  gggagaaag  ggaggggag  gaggcgagg  420
ggcggggag  cgaggcgag  ggcaggcgg  ccgtggggg  ggcgactgg  caaggcggg  480
tccaggcag  agagaggtg  nggcccggc  gagtcggga  aaggctacc  gactnnnnn  540
gaagggcga  ccagagctg  cggtggggc  gggcggggc  gaagggtgc  aagcccggc  600
cctgggcgc  gatcacggc  cggggagac  ggccgccca  cggagaccg  agccgcncg  660
cctccgctc  gggatgtcg  agcgatcca  gcatccagg  cgctgacgg  gcgagnccg  720
ggatgggac  gcgcccgca  ctccggctc  tgaaggccc  tctccttct  gggctgaac  780
ctgtgtcca  ctcccttca  gatcagcgc  gtgagaacc  gtccctgac  agcaatgtt  840
ctggcctgc  gtgcaatgc  tccgtggac  tcattggca  ctgctggcc  cggagccct  900
cgggccagt  ggtggtccg  ccctgccct  cctttttct  cggtgtccg  tacaacacg  960
caaacaatg  ctaccggga  tgcctggcc  acggcagct  ggcagcccg  gtgaattat  1020
ctgagtgcc  ggagattct  aacgaagag  agaagagca  agtacacta  catgttgca  1080
tcatcatca  ctacctggg  cactgcatc  ccctggtag  cctcctggt  gcctttgtc  1140
tcttcttgc  gctcaggag  atccggtgc  tgagaaaca  catccactg  aacctcatc  1200
cggctttca  cctacgcaa  gccacgtgg  ttgtggtcc  gctcaccgt  agccccgag  1260
tgcaccaga  caatgtggc  tggtgtagg  tggtgacag  cgcctacaa  tacttccat  1320
taaccaact  cttctggat  ttcggtgag  gctgctacc  gcacacagc  attgtgctc  1380
cgtactcca  cgaccgtct  cgcaagtgg  tgttcgtct  cattggctg  ggtgtacct  1440
tccccatca  tgtggcttg  gccattggg  agctgcact  cgacaatga  aagtgctgg  1500
ttggcaaac  tcctggggt  tacactgac  acatctacc  gggccccat  atcctggtc  1560
tgctgatca  ctttatctt  ctcttcaac  ttgtccgca  cctcatgac  aaactccgg  1620
catccacta  atctgagac  attcagtac  ggaaggctg  gaaggccac  ctggtgctc  1680
tgccccttc  gggcatcac  tacatgttg  tcttcgtca  ccctggaga  gacgaggtc  1740
ccagggtcg  cttcatcta  ttcaactct  ttctggagt  ctttcaggg  ttctttgtg  1800
ctgtgttct  ctgttttct  aacagtgag  tccgctccg  tatccggaa  aggtggcgt  1860
ggtggcagg  caagcactc  atcagagcc  gagtggccc  agctatgtc  atccccacc  1920
ccccgacca  agtcagctt  cacagcatc  agcagtcca  agcagtgtg  gctccaggc  1980
acagagcag  ccccaagac  tgaggccgg  gagatgatg  aagctcact  acgagccag  2040
ctgc  2044



<210> 8665
<211> 415
<212> PRT
<213> Rattus norvegicus
<308> NP_112261
<400> 8665

Met Gly Arg Arg Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
  1               5                  10                  15
Gly Leu Asn Pro Val Ser Thr Ser Leu Gln Asp Gln Arg Cys Glu Asn 
             20                  25                  30
Leu Ser Leu Thr Ser Asn Val Ser Gly Leu Gln Cys Asn Ala Ser Val 
         35                  40                  45
Asp Leu Ile Gly Thr Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
     50                  55                  60
Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Thr Thr 
 65                  70                  75                  80
Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                 85                  90                  95
Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
             100                105                110
Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
         115                120                125
Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
     130                135                140
Arg Ser Ile Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser 
 145                150                155                160
Ala Phe Ile Leu Arg Asn Ala Thr Trp Phe Val Val Gln Leu Thr Val 
                 165                170                175
Ser Pro Glu Val His Gln Ser Asn Val Ala Trp Cys Arg Leu Val Thr 
             180                185                190
Ala Ala Tyr Asn Tyr Phe His Val Thr Asn Phe Phe Trp Met Phe Gly 
         195                200                205
Glu Gly Cys Tyr Leu His Thr Ala Ile Val Leu Thr Tyr Ser Thr Asp 
     210                215                220
Arg Leu Arg Lys Trp Met Phe Val Cys Ile Gly Trp Gly Val Pro Phe 
 225                230                235                240
Pro Ile Ile Val Ala Trp Ala Ile Gly Lys Leu His Tyr Asp Asn Glu 
                 245                250                255
Lys Cys Trp Phe Gly Lys Arg Pro Gly Val Tyr Thr Asp Tyr Ile Tyr 
             260                265                270
Gln Gly Pro Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe 
         275                280                285
Asn Ile Val Arg Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser 
     290                295                300
Glu Thr Ile Gln Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu 
 305                310                315                320
Pro Leu Leu Gly Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu 
                 325                330                335
Asp Glu Val Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu 
             340                345                350
Ser Phe Gln Gly Phe Phe Val Ser Val Phe Tyr Cys Phe Leu Asn Ser 
         355                360                365
Glu Val Arg Ser Ala Ile Arg Lys Arg Trp Arg Arg Trp Gln Asp Lys 
     370                375                380
His Ser Ile Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro Thr Ser 
 385                390                395                400
Pro Thr Arg Val Ser Phe His Ser Ile Lys Gln Ser Thr Ala Val 
                 405                410                415



<210> 8666
<211> 1285
<212> DNA
<213> Homo sapiens
<308> L23332
<400> 8666

cccgggcat  caggacggt  gccgagcga  cccgaggat  ggagggcac  cgcagctcc  60
tctcgtcaa  gcccttctc  ttctggggc  gaaccccgt  tctgcctcc  tccaggacc  120
gcactgcga  agcctgtcc  tggccagca  catctcagg  ctgcagtgc  acgcatccg  180
ggacctcat  ggcacctgc  ggccccgca  ccctgcggg  cagctagtg  ttcggccct  240
ccctgcctt  ttctatggt  tccgctaca  taccacaaa  aatggctac  gggagtgcc  300
ggccaatgg  agctgggcc  cccgcgtga  ttactccga  tgccaggag  tcctcaatg  360
ggagaaaaa  agcaaggtg  actaccatg  cgcagtcat  atcaactac  tgggccact  420
tatctccct  gtggccctc  tggtggcct  tgtcctctt  ctgcggctc  ggagcatcc  480
gtgcctgcg  aacatcatc  actggaacc  catctccgc  ttcatcctg  gcaacgcca  540
ctggttcgt  gtccagcta  ccatgagcc  cgaggtcca  cagagcaac  tgggctggt  600
caggttggt  acagccgcc  acaactact  ccatgtgac  aacttcttc  ggatgttcg  660
cgagggctg  tacctgcac  cagccatcg  gctcaccta  tccactgac  ggctgcgca  720
atggatgtt  atctgcatt  gctggggtg  gcccttccc  atcattgtg  cctgggcca  780
tgggaagct  tactacgac  atgagaagt  ctggtttgg  aaaaggcct  gggtgtaca  840
cgactacat  taccagggc  ccatgatcc  ggtcctgct  atcaatttc  tcttccttt  900
caacatcgt  cgcatcctc  tgaccaagc  ccgggcatc  accacgtct  agaccattc  960
gtacaggaa  gctgtgaaa  ccactctgg  gctgctgcc  ctcctgggc  tcacctaca  1020
gctgttctt  gtcaatccc  gggaggatg  ggtctcccg  gtcgtcttc  tctacttca  1080
ctccttcct  gaatccttc  agggcttct  tgtgtctgt  ttctactgt  tcctcaata  1140
tgaggtccg  tctgccatc  ggaagaggt  gcaccggtg  caggacaag  actcgatcc  1200
tgcccgagt  gcccgtgcc  tgtccatcc  cacctcccc  acccgtgtc  gctttcaca  1260
catcaagca  tccacagca  tctga  1285



<210> 8667
<211> 444
<212> PRT
<213> Homo sapiens
<308> P34998
<400> 8667

Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
  1               5                  10                  15
Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
             20                  25                  30
Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
         35                  40                  45
Asp Leu Ile Gly Thr Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
     50                  55                  60
Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Thr Thr 
 65                  70                  75                  80
Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                 85                  90                  95
Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
             100                105                110
Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
         115                120                125
Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
     130                135                140
Arg Pro Gly Cys Thr His Trp Gly Asp Gln Ala Asp Gly Ala Leu Glu 
 145                150                155                160
Val Gly Ala Pro Trp Ser Gly Ala Pro Phe Gln Val Arg Arg Ser Ile 
                 165                170                175
Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser Ala Phe Ile 
             180                185                190
Leu Arg Asn Ala Thr Trp Phe Val Val Gln Leu Thr Met Ser Pro Glu 
         195                200                205
Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val Thr Ala Ala Tyr 
     210                215                220
Asn Tyr Phe His Val Thr Asn Phe Phe Trp Met Phe Gly Glu Gly Cys 
 225                230                235                240
Tyr Leu His Thr Ala Ile Val Leu Thr Tyr Ser Thr Asp Arg Leu Arg 
                 245                250                255
Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe Pro Ile Ile 
             260                265                270
Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu Lys Cys Trp 
         275                280                285
Phe Gly Lys Arg Pro Gly Val Tyr Thr Asp Tyr Ile Tyr Gln Gly Pro 
     290                295                300
Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe Asn Ile Val 
 305                310                315                320
Arg Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile 
                 325                330                335
Gln Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu Pro Leu Leu 
             340                345                350
Gly Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Glu Val 
         355                360                365
Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu Ser Phe Gln 
     370                375                380
Gly Phe Phe Val Ser Val Phe Tyr Cys Phe Leu Asn Ser Glu Val Arg 
 385                390                395                400
Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln Asp Lys His Ser Ile 
                 405                410                415
Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro Thr Ser Pro Thr Arg 
             420                425                430
Val Ser Phe His Ser Ile Lys Gln Ser Thr Ala Val 
         435                440



<210> 8668
<211> 1705
<212> DNA
<213> Rattus norvegicus
<308> U53706
<400> 8668

gccggtgct  ggctctgta  ctcggtact  cagcctctc  tcatggcct  ggaaaagcc  60
caggaccta  tggtcacct  caccgcgcc  gtcaacatc  cggttatca  atactgggg  120
aagcgggat  aagcgctga  cctgcccat  aacccctcc  tgagcgtca  gctgcacca  180
gaccagcta  aaaccacca  aactgcggc  attagcaag  acttcacag  ggaccgcat  240
tggctgaac  gtcgtgagg  ggacgtggg  cagccacgg  tccaggcct  cctgagaga  300
attcgccgc  tggctcgga  gcggaggag  acgggagac  gggatgccc  gcccctcag  360
ctcggctat  aggtgcacg  ggcgtcagt  aacaacttc  ccaccgctg  aggcctggc  420
tcctcagca  ccggctacg  ctgcctagc  tataccttg  cccgggtct  cggggttga  480
ggagacctc  cagaagtgg  ccggcgggg  tcaggcagc  catgccgca  cctctacgg  540
ggcttcgtg  agtggcaga  gggggaaca  gccgatggg  aggacagca  cgcccggca  600
atagcccca  agtggcact  gccccagct  cgagttctt  tccttgtgg  gagtgcaga  660
aagaagccg  cgggcagca  agtgggcat  cagaccagc  tggcgacca  taccctgct  720
aagttccgg  ctgagtcca  tgtgcctga  cgcatgaag  agatgaccc  ttgcatcca  780
gagcaggac  tccaggcct  cgcccagct  accatgaag  acagcaacc  gtttcacgc  840
acctgcctc  acaccttcc  gcccatctc  tacctcaat  acacctcca  gcgcatcat  900
cagctagtc  accgcttca  cgcccacca  gggcagacg  aggtggcgt  cacatttga  960
gcgggcccc  atgctgtga  cttcactct  gaggacacc  tggccgagt  tgtggcggc  1020
gtaaggcac  gcttccccc  tgctgcgaa  ggagacaag  ttctcaagg  gctgcaggt  1080
gcacccgtt  ttctctccg  tgagctgaa  acttcgctg  ctacggagc  cagccctgg  1140
ggggttcag  acatcattg  cactcaggt  ggaccagga  ctcaagtcc  agacgaccc  1200
caccatcat  tgctaggcc  ggatggcct  ccacagcgg  acctttgat  tctcccatg  1260
gcatctgga  aaaggggtt  ctcccggga  ctcgggagc  cctgtgctg  tgggccacg  1320
ccaaaggct  gcttgatga  acctagggg  gtctcctgt  atgagcagc  gtctgggca  1380
ccggggacc  ctctcaagt  cctcacctt  ctgctggct  gccgacctt  gggaagagg  1440
gtcggcgtc  ctcccaccg  agatgcccc  gagggcctc  aagcgtgaa  gatgagggc  1500
cagacagca  tgcctctgt  gagactcag  ccacagttt  tttgagaag  ctcctggtg  1560
gggtagggg  tgtggaacc  acaggtagg  tccattgtg  gtgtggatg  accacgaag  1620
tgcagttga  ggacccgat  accacagga  taaagtgtg  cactgctgc  tgccaaaaa  1680
aaaaaaaaa  aaaaaaaaa  aaacc  1705



<210> 8669
<211> 401
<212> PRT
<213> Rattus norvegicus
<308> Q62967
<400> 8669

Met Ala Ser Glu Lys Pro Gln Asp Leu Met Val Thr Cys Thr Ala Pro 
  1               5                  10                  15
Val Asn Ile Ala Val Ile Lys Tyr Trp Gly Lys Arg Asp Glu Ala Leu 
             20                  25                  30
Ile Leu Pro Ile Asn Pro Ser Leu Ser Val Thr Leu His Gln Asp Gln 
         35                  40                  45
Leu Lys Thr Thr Thr Thr Ala Ala Ile Ser Lys Asp Phe Thr Glu Asp 
     50                  55                  60
Arg Ile Trp Leu Asn Gly Arg Glu Glu Asp Val Gly Gln Pro Arg Leu 
 65                  70                  75                  80
Gln Ala Cys Leu Arg Glu Ile Arg Arg Leu Ala Arg Lys Arg Arg Ser 
                 85                  90                  95
Thr Gly Asp Gly Asp Ala Leu Pro Leu Ser Leu Gly Tyr Lys Val His 
             100                105                110
Val Ala Ser Val Asn Asn Phe Pro Thr Ala Ala Gly Leu Ala Ser Ser 
         115                120                125
Ala Ala Gly Tyr Ala Cys Leu Ala Tyr Thr Leu Ala Arg Val Tyr Gly 
     130                135                140
Val Glu Gly Asp Leu Ser Glu Val Ala Arg Arg Gly Ser Gly Ser Ala 
 145                150                155                160
Cys Arg Ser Leu Tyr Gly Gly Phe Val Glu Trp Gln Met Gly Glu Gln 
                 165                170                175
Ala Asp Gly Lys Asp Ser Ile Ala Arg Gln Ile Ala Pro Glu Trp His 
             180                185                190
Trp Pro Gln Leu Arg Val Leu Ile Leu Val Val Ser Ala Glu Lys Lys 
         195                200                205
Pro Thr Gly Ser Thr Val Gly Met Gln Thr Ser Val Ala Thr Ser Thr 
     210                215                220
Leu Leu Lys Phe Arg Ala Glu Ser Ile Val Pro Glu Arg Met Lys Glu 
 225                230                235                240
Met Thr Arg Cys Ile Gln Glu Gln Asp Phe Gln Ala Phe Ala Gln Leu 
                 245                250                255
Thr Met Lys Asp Ser Asn Gln Phe His Ala Thr Cys Leu Asp Thr Phe 
             260                265                270
Pro Pro Ile Ser Tyr Leu Asn Asp Thr Ser Arg Arg Ile Ile Gln Leu 
         275                280                285
Val His Arg Phe Asn Ala His His Gly Gln Thr Lys Val Ala Tyr Thr 
     290                295                300
Phe Asp Ala Gly Pro Asn Ala Val Ile Phe Thr Leu Glu Asp Thr Val 
 305                310                315                320
Ala Glu Phe Val Ala Ala Val Arg His Ser Phe Pro Pro Ala Ala Asn 
                 325                330                335
Gly Asp Lys Phe Leu Lys Gly Leu Gln Val Ala Pro Val Leu Leu Ser 
             340                345                350
Asp Glu Leu Lys Thr Ser Leu Ala Thr Glu Pro Ser Pro Gly Gly Val 
         355                360                365
Gln Tyr Ile Ile Ala Thr Gln Val Gly Pro Gly Pro Gln Val Leu Asp 
     370                375                380
Asp Pro His His His Leu Leu Gly Pro Asp Gly Leu Pro Gln Arg Asp 
 385                390                395                400
Leu 
                 405



<210> 8670
<211> 1812
<212> DNA
<213> Homo sapiens
<308> NM_002461
<400> 8670

tgggaccat  gcctcggag  agccgctgg  ggcagtcac  tgtacagcg  cggtcaaca  60
cgcggtcat  aagtactgg  gcaagcgcg  tgaagagct  gttctgccc  tcaactcct  120
cctgagcgt  actctgcac  aggaccagt  aaaaaccac  acaacagcc  tcatcagca  180
ggacttcac  gaggaccgg  tttggctga  tggccggga  gaggatgtg  ggcagccga  240
gctgcaggc  tgcctgcgg  agatccgct  cctggcccg  aagcggagg  actcacggg  300
tggggaccc  ctgccctcc  gcctcagct  caaggtgca  gtggcatcg  tgaacaact  360
ccccacggc  gcgggcctg  cctcctcag  ggcgggcta  gcctgccta  cctacaccc  420
ggcccgtgt  tacggcgtg  agagtgacc  ctcagaagt  gctcgccgg  gctcaggca  480
cgcctgccg  agcctgtat  ggggctttg  ggagtggca  atgggagag  aggccgacg  540
gaaggacag  atcgctcgg  aagtggccc  cgagtcaca  tggcctgaa  tccgcgtgc  600
catccttgt  gtgagcgct  agaagaagc  gacaggcag  accgtgggc  tgcgggcca  660
tgtggagac  agccccctg  ttcggttcc  ggccgagtc  gtggtgccc  cgcgcatgg  720
ggagatggc  cgctgcatc  gggagcgag  cttccccag  ttcgcccag  tgaccatga  780
ggacagcaa  cagttccac  ccacctgcc  cgacacctt  ccgcccatc  cttacctca  840
tgccatctc  tggcgcatc  tccacctgg  gcaccgctt  aacgcccac  acggggaca  900
caaggtggc  tacaccttt  acgcgggcc  caatgccgt  atcttcacc  tggacgaca  960
tgtggctga  tttgtggct  ctgtgtggc  cggctttcc  ccaggctcg  atggagaca  1020
gtttctgaa  gggctgcag  tgaggccgg  ccctctctc  gctgagctt  aggctgcgc  1080
ggccatgga  ccgaccccc  gtggggtca  atacatcat  gtcactcag  tggggccag  1140
gcctcaaat  ctggatgac  cctgcgccc  cctcctggg  cctgacggc  tgccgaagc  1200
agctgcctg  ctgcctcag  agggaccgc  tgccgcttg  agaaggggt  gcctcgccg  1260
agctaggga  cggatgtgg  gggctggcc  gactcctgg  acatgtggg  ggtggcttg  1320
ccccgggcc  atgggcagc  tgctgtggg  cagtgcagg  agtcctgcg  ccgcccagg  1380
gtcaggaga  gtccccgcc  agtgcttca  ctgccctaa  ctgcaccag  gctttgcca  1440
gatgggatg  ggagggggt  tgagaactg  cagagcctc  gtgcagcag  gctgaaggg  1500
tttctcacc  cagctctgg  tatgcccag  tctctgaga  aggagctca  tggggaggt  1560
gtccctcca  cggaccagg  aaggggtca  tgtgctggg  gcagcctcc  tgggcctca  1620
gaaaccacc  agtgcctcg  atggtggct  cccacggcg  ttctgctga  accctgccc  1680
cggcccagg  gtctcggag  gtggctgcc  acggcctgg  tgtggctgg  atggtggca  1740
gagtgggca  cagtgcggc  ccggtggcc  tggggaata  accagcatt  ctgccaaaa  1800
aaaaaaaaa  aa  1812



<210> 8671
<211> 400
<212> PRT
<213> Homo sapiens
<308> P53602
<400> 8671

Met Ala Ser Glu Lys Pro Leu Ala Ala Val Thr Cys Thr Ala Pro Val 
  1               5                  10                  15
Asn Ile Ala Val Ile Lys Tyr Trp Gly Lys Arg Asp Glu Glu Leu Val 
             20                  25                  30
Leu Pro Ile Asn Ser Ser Leu Ser Val Thr Leu His Gln Asp Gln Leu 
         35                  40                  45
Lys Thr Thr Thr Thr Ala Val Ile Ser Lys Asp Phe Thr Glu Asp Arg 
     50                  55                  60
Ile Trp Leu Asn Gly Arg Glu Glu Asp Val Gly Gln Pro Arg Leu Gln 
 65                  70                  75                  80
Ala Cys Leu Arg Glu Ile Arg Cys Leu Ala Arg Lys Arg Arg Asn Ser 
                 85                  90                  95
Arg Asp Gly Asp Pro Leu Pro Ser Ser Leu Ser Cys Lys Val His Val 
             100                105                110
Ala Ser Val Asn Asn Phe Pro Thr Ala Ala Gly Leu Ala Ser Ser Ala 
         115                120                125
Ala Gly Tyr Ala Cys Leu Ala Tyr Thr Leu Ala Arg Val Tyr Gly Val 
     130                135                140
Glu Ser Asp Leu Ser Glu Val Ala Arg Arg Gly Ser Gly Ser Ala Cys 
 145                150                155                160
Arg Ser Leu Tyr Gly Gly Phe Val Glu Trp Gln Met Gly Glu Gln Ala 
                 165                170                175
Asp Gly Lys Asp Ser Ile Ala Arg Gln Val Ala Pro Glu Ser His Trp 
             180                185                190
Pro Glu Leu Arg Val Leu Ile Leu Val Val Ser Ala Glu Lys Lys Leu 
         195                200                205
Thr Gly Ser Thr Val Gly Met Arg Ala Ser Val Glu Thr Ser Pro Leu 
     210                215                220
Leu Arg Phe Arg Ala Glu Ser Val Val Pro Ala Arg Met Ala Glu Met 
 225                230                235                240
Ala Arg Cys Ile Arg Glu Arg Asp Phe Pro Ser Phe Ala Gln Leu Thr 
                 245                250                255
Met Lys Asp Ser Asn Gln Phe His Ala Thr Cys Leu Asp Thr Phe Pro 
             260                265                270
Pro Ile Ser Tyr Leu Asn Ala Ile Ser Trp Arg Ile Ile His Leu Val 
         275                280                285
His Arg Phe Asn Ala His His Gly Asp Thr Lys Val Ala Tyr Thr Phe 
     290                295                300
Asp Ala Gly Pro Asn Ala Val Ile Phe Thr Leu Asp Asp Thr Val Ala 
 305                310                315                320
Glu Phe Val Ala Ala Val Trp His Gly Phe Pro Pro Gly Ser Asn Gly 
                 325                330                335
Asp Thr Phe Leu Lys Gly Leu Gln Val Arg Pro Ala Pro Leu Ser Ala 
             340                345                350
Glu Leu Gln Ala Ala Leu Ala Met Glu Pro Thr Pro Gly Gly Val Lys 
         355                360                365
Tyr Ile Ile Val Thr Gln Val Gly Pro Gly Pro Gln Ile Leu Asp Asp 
     370                375                380
Pro Cys Ala His Leu Leu Gly Pro Asp Gly Leu Pro Lys Pro Ala Ala 
 385                390                395                400



<210> 8672
<211> 1610
<212> DNA
<213> Rattus norvegicus
<308> U53922
<400> 8672

ggccgggcg  aactttcca  aacgctcgg  gggtggtag  ggagcagcg  ctggccgag  60
tgcgctgtg  tacgctcct  tttccgctc  ccggcgccg  cccgctcac  ggctgtaaa  120
aatggtgaa  gaaactact  actatgatg  tctgggggt  aaacccaat  ccacccagg  180
agaattgaa  aaggcatat  gaaaattgg  cttgaagta  caccctgat  aaaatccaa  240
tgaaggaga  aagtttaaa  agatttctc  agcttatga  gttcttgct  attccaaga  300
aagggaact  tatgataaa  ggggcgagc  ggcgattaa  gagggcgga  caggtggag  360
ttttggctc  cccatggat  tctttgata  gttctttgg  ggaggagga  ggatgcaaa  420
agaaaggag  ggtaaaaat  tcgtgcatc  gctctcagt  accttagaa  acttatata  480
tggtgcaac  aggaaactg  ctctgcaaa  aaatgtgat  tgtgacaaa  gtgaaggcc  540
aggtggtaa  aaaggagca  tagagtgct  tcccaactg  cgggggact  gcatgcaga  600
caggattca  cagattgga  caggaatgg  tcagcaaat  cagtcagtg  gcatggagt  660
ccagggtca  ggagaacgc  tcagtccta  agacagatg  aaaagctgc  atggaagaa  720
gatagttcg  gagaagaaa  ttttagaag  tcatattga  aaaggcatg  aagatggtc  780
gaagataac  ttccacggt  aaggagacc  agaaccagg  ctggagcca  gagatatta  840
cattgtgtt  gatcagaag  accatgctg  ttttacaag  cgaggagaa  accttttca  900
gtgtatgga  atacagctg  ttgaagcat  gtgtggctt  caaaagcca  tatctactc  960
tgacaaccg  accatagtc  tcacctctc  tccaggtca  attgtcaag  atggggata  1020
aaaatgtgt  ctaaatgaa  gtatgccaa  ataccgtcg  ccatatgaa  agggacgtc  1080
aatcattga  tttaaggta  actttcctg  aaatggctt  ctctctcct  ataaactct  1140
tttgctgga  aaactcctt  ctgaaagga  ggaagtaga  gagactgat  aaatggatc  1200
ggtagaact  gtggacttt  atccaaatc  ggaaagacg  cgtcattat  atggagaag  1260
gtatgagga  gatgagcat  accccagag  tggcgttca  tgtcagacc  cttaatggg  1320
cagtcactc  ttgaccttg  gtatgcagt  gtgaatgtg  gaaggactg  aatcataat  1380
tgctcacta  ttggctgtt  tttttgttt  aatattcaa  tatagtagt  ttttaaaag  1440
taaatgaag  ataaacaca  atataaaag  tctgacttt  ccctgtatg  atgatgact  1500
taatgttca  gatgaaaat  aatacttgt  aaaaactag  ttaaaaaat  ccctagcat  1560
tgttaggcc  tatcttgtg  aactgataa  agcgtgtac  ttagactgac  1610



<210> 8673
<211> 397
<212> PRT
<213> Rattus norvegicus
<308> P54102
<400> 8673

Met Val Lys Glu Thr Thr Tyr Tyr Asp Val Leu Gly Val Lys Pro Asn 
  1               5                  10                  15
Ala Thr Gln Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys 
             20                  25                  30
Tyr His Pro Asp Lys Asn Pro Asn Glu Gly Glu Lys Phe Lys Gln Ile 
         35                  40                  45
Ser Gln Ala Tyr Glu Val Leu Ala Asp Ser Lys Lys Arg Glu Leu Tyr 
     50                  55                  60
Asp Lys Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ala Gly Gly Gly 
 65                  70                  75                  80
Phe Gly Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly Gly 
                 85                  90                  95
Arg Met Gln Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu Ser 
             100                105                110
Val Thr Leu Glu Asp Leu Tyr Asn Gly Ala Thr Arg Lys Leu Ala Leu 
         115                120                125
Gln Lys Asn Val Ile Cys Asp Lys Cys Glu Gly Arg Gly Gly Lys Lys 
     130                135                140
Gly Ala Val Glu Cys Cys Pro Asn Cys Arg Gly Thr Gly Met Gln Ile 
 145                150                155                160
Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Ser Val 
                 165                170                175
Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro Lys Asp Arg 
             180                185                190
Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys Lys Ile Leu 
         195                200                205
Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys Ile Thr Phe 
     210                215                220
His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly Asp Ile Ile 
 225                230                235                240
Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg Arg Gly Glu 
                 245                250                255
Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala Leu Cys Gly 
             260                265                270
Phe Gln Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile Val Ile Thr 
         275                280                285
Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys Cys Val Leu 
     290                295                300
Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys Gly Arg Leu 
 305                310                315                320
Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe Leu Ser Pro 
                 325                330                335
Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg Lys Glu Val 
             340                345                350
Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp Phe Asp Pro 
         355                360                365
Asn Gln Glu Arg Arg Arg His Tyr Asn Gly Glu Ala Tyr Glu Asp Asp 
     370                375                380
Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser 
 385                390                395



<210> 8674
<211> 1474
<212> DNA
<213> Homo sapiens
<308> BC008182
<400> 8674

gctcggtga  aggcggagg  gcggtaact  ccccggctg  gcacagctc  gcgctcctt  60
ccgctccct  acacaccgg  ctcagcccg  accggcagt  gaagatggt  aaagaaaca  120
cttactacg  tgttttggg  gtcaaaccc  atgctactc  ggaagaatt  aaaaaggct  180
ataggaaac  ggccttgaa  taccatcct  ataagaacc  aaatgaagg  gagaagttt  240
aacagattt  tcaagctta  gaagttctc  ctgatgcaa  gaaaaggga  ttatatgac  300
aaggaggag  acaggcaat  aaagagggt  gagcaggtg  cggttttgg  tcccccatg  360
acatctttg  tatgttttt  ggaggagga  gaaggatgc  gagagaaag  agaggtaaa  420
atgttgtac  tcagctctc  gtaacccta  aagacttat  taatggtgc  acaagaaaa  480
tggctctgc  aaagaatgt  atttgtgac  aatgtgaag  tagaggagg  aagaaagga  540
cagtagagt  ctgtcccaa  tgccgaggt  ctggaatgc  aataagaat  catcagata  600
gacctggaa  ggttcagca  attcagtct  tgtgcatgg  gtgccaggg  catggggag  660
ggatcagtc  taaagatag  tgtaaaagc  gcaacggaa  gaagatagt  cgagagaag  720
aaattttag  agttcatat  gacaaaggc  tgaaagatg  ccagaagat  acattccat  780
gtgaaggag  ccaagaacc  ggactggag  caggcgata  tatcattgt  ttagatcag  840
aggaccatg  tgtttttac  cgacgagga  aagaccttt  catgtgtat  gacatacag  900
tcgttgaag  actgtgtgg  ttccagaag  caatatcta  tcttgacaa  cgaaccatc  960
tcatcacct  tcatccagg  cagattgtc  agcatggag  tatcaagtg  gtactaaat  1020
aaggcatgc  aatttatcg  agaccatat  aaaagggtc  cctaatcat  gaatttaag  1080
taaactttc  tgagaatgg  tttctctct  ctgataaac  gtctttgct  gaaaaactc  1140
tacccgaga  gaaggaagt  gaagagact  atgagatgg  ccaagtaga  ctggtggac  1200
ttgatccaa  tcaggaaag  cggcgccac  acaatggag  agcatatga  gatgatgaa  1260
atcatccca  aggtggtgt  cagtgtcag  cctcttaat  ggccagtga  taacactca  1320
tgctggcat  taatgtgca  tagtgaatg  gtgaaggac  gtaatcata  tatgctcac  1380
acttgctct  gtttttgtt  taataaact  tagtagtgt  ttaaaaagt  aaatgaaga  1440
taaacgcaa  tataaaagc  aaaaaaaaa  aaaa  1474



<210> 8675
<211> 397
<212> PRT
<213> Homo sapiens
<308> P31689
<400> 8675

Met Val Lys Glu Thr Thr Tyr Tyr Asp Val Leu Gly Val Lys Pro Asn 
  1               5                  10                  15
Ala Thr Gln Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys 
             20                  25                  30
Tyr His Pro Asp Lys Asn Pro Asn Glu Gly Glu Lys Phe Lys Gln Ile 
         35                  40                  45
Ser Gln Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Glu Leu Tyr 
     50                  55                  60
Asp Lys Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ala Gly Gly Gly 
 65                  70                  75                  80
Phe Gly Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly Gly 
                 85                  90                  95
Arg Met Gln Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu Ser 
             100                105                110
Val Thr Leu Glu Asp Leu Tyr Asn Gly Ala Thr Arg Lys Leu Ala Leu 
         115                120                125
Gln Lys Asn Val Ile Cys Asp Lys Cys Glu Gly Arg Gly Gly Lys Lys 
     130                135                140
Gly Ala Val Glu Cys Cys Pro Asn Cys Arg Gly Thr Gly Met Gln Ile 
 145                150                155                160
Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Ser Val 
                 165                170                175
Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro Lys Asp Arg 
             180                185                190
Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys Lys Ile Leu 
         195                200                205
Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys Ile Thr Phe 
     210                215                220
His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly Asp Ile Ile 
 225                230                235                240
Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg Arg Gly Glu 
                 245                250                255
Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala Leu Cys Gly 
             260                265                270
Phe Gln Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile Val Ile Thr 
         275                280                285
Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys Cys Val Leu 
     290                295                300
Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys Gly Arg Leu 
 305                310                315                320
Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe Leu Ser Pro 
                 325                330                335
Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg Lys Glu Val 
             340                345                350
Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp Phe Asp Pro 
         355                360                365
Asn Gln Glu Arg Arg Arg His Tyr Asn Gly Glu Ala Tyr Glu Asp Asp 
     370                375                380
Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser 
 385                390                395



<210> 8676
<211> 1092
<212> DNA
<213> Rattus norvegicus
<308> U54632
<400> 8676

aggggaagt  ccgagacaa  ggagcgccg  cgcctctgc  gccgcgacg  tccgggccg  60
ggtcgccca  ggactttga  tatgtcggg  attgccctc  gccgacttg  gcaggagag  120
aaagcctgg  ggaaggacc  cccttttgg  tttgtggct  tcccaacaa  gaaccctga  180
ggcacgatg  acctgatga  ctgggagtg  gctatccct  gaaagaagg  gactccgtg  240
gaaggaggc  tgttcaagc  acggatgct  ttcaaagat  actatccgt  ctcaccacc  300
aaatgtaaa  ttgagccac  actgtttca  ccaaacgtg  atccttctg  cacagtgtg  360
ctgtccatc  tggaggaag  caaggactg  cggccagct  ttacgatca  acagatctt  420
ttaggaata  aagaacttc  aaatgaacc  aatattcaa  acccagctc  agcagaggc  480
tatacaatt  actgccaaa  cagagtgga  tatgagaaa  gggttcgag  acaagcgaa  540
aagtttgcc  cctcataag  agcggcccg  gctccatga  gaggaaggg  ttggcttgg  600
aagaacttg  ttacaacct  ttgcagatc  aagtcgctc  gtacagtta  tagtagcct  660
ggagggttg  gcgggcgcc  ttttccatt  ccgccactg  catattcag  cttttgtat  720
tttgattat  gagtaaaac  tgcttttat  ttaatattg  tgtcagtat  tcaactgct  780
taaaatgat  aacttttgt  cttggtaag  cctaggagc  agtttcttc  cgtccgctc  840
gatcgaggc  tgttcccca  tgttcagag  tctggcctc  agctggctg  atgacagaa  900
cacactgtc  ctccttcct  ccctaccct  gtccttctc  gaaacctgg  ctgttgctt  960
tgagcctca  atccaaagt  ggccagcat  tccattctg  accacttcc  ttgtgttta  1020
atggcgttt  gtctgtgtt  ctgtttaga  taaataaac  gtttatata  aaaaaaaaa  1080
aaaaaaaaa  aa  1092



<210> 8677
<211> 158
<212> PRT
<213> Rattus norvegicus
<308> P50550
<400> 8677

Met Ser Gly Ile Ala Leu Ser Arg Leu Ala Gln Glu Arg Lys Ala Trp 
  1               5                  10                  15
Arg Lys Asp His Pro Phe Gly Phe Val Ala Val Pro Thr Lys Asn Pro 
             20                  25                  30
Asp Gly Thr Met Asn Leu Met Asn Trp Glu Cys Ala Ile Pro Gly Lys 
         35                  40                  45
Lys Gly Thr Pro Trp Glu Gly Gly Leu Phe Lys Leu Arg Met Leu Phe 
     50                  55                  60
Lys Asp Asp Tyr Pro Ser Ser Pro Pro Lys Cys Lys Phe Glu Pro Pro 
 65                  70                  75                  80
Leu Phe His Pro Asn Val Tyr Pro Ser Gly Thr Val Cys Leu Ser Ile 
                 85                  90                  95
Leu Glu Glu Asp Lys Asp Trp Arg Pro Ala Ile Thr Ile Lys Gln Ile 
             100                105                110
Leu Leu Gly Ile Gln Glu Leu Leu Asn Glu Pro Asn Ile Gln Asp Pro 
         115                120                125
Ala Gln Ala Glu Ala Tyr Thr Ile Tyr Cys Gln Asn Arg Val Glu Tyr 
     130                135                140
Glu Lys Arg Val Arg Ala Gln Ala Lys Lys Phe Ala Pro Ser 
 145                150                155



<210> 8678
<211> 1077
<212> DNA
<213> Homo sapiens
<308> U29092
<400> 8678

aattcggca  gagggactt  gaacatgtc  gggatcgcc  tcagcagac  cgcccagga  60
aggaaagca  ggaggaaag  ccacccatt  ggtttcgtg  ctgtcccaa  aaaaaatcc  120
gatggcacg  tgaacctca  gaactggga  tgcgccatt  caggaaaga  agggactcc  180
tgggaagga  gcttgttta  actacggat  cttttcaaa  atgattatc  atcttcgcc  240
ccaaaatgt  aattcgaac  accattatt  cacccgaat  tgtaccctt  ggggacagt  300
tgcctgtcc  tcttagagg  ggacaagga  tggaggcca  ccatcacaa  caaacagat  360
ctattagga  tacaggaac  tctaaatga  ccaaatatc  aagacccag  tcaagcaga  420
gcctacacg  tttactgcc  aaacagagt  gagtacgag  aaagggtcc  agcacaagc  480
aagaagttt  cgccctcat  agcagcgac  ttgtggcat  gtcaaaagg  agggattgg  540
ttggcaaga  cttgtttac  acatttttg  aaatctaaa  ttgctccat  caatgacta  600
tcacctggg  gggttgggc  ggcgccatc  tccattgcc  ccgcgggtg  gcggtctcg  660
ttcgctgaa  tgcccgttt  catacaggg  ctcttcctt  ggtcttttg  atttttgat  720
gttatgtaa  actcgcttt  attttaata  tgatgtcag  atttcaact  ctgtaaaat  780
ataaacttt  atacttggg  aagtccccc  gggcgagtt  ctcgctctg  gatgcaggc  840
tgcttctca  cgtgcagag  tgcacttgg  ctcagctgg  tgtatggaa  tgcaccctc  900
ctcctgccg  tcctctcta  aaccttcta  aacctgggc  gtgctgctt  tgagcctca  960
accccaggg  agcatctcg  ttctgcgcc  cttcctttg  gttatatgg  gttttgtct  1020
tgttgctgt  tagagtaaa  aaactgttt  tataaaaaa  aaaaaaaaa  aactcga  1077



<210> 8679
<211> 158
<212> PRT
<213> Homo sapiens
<308> P50550
<400> 8679

Met Ser Gly Ile Ala Leu Ser Arg Leu Ala Gln Glu Arg Lys Ala Trp 
  1               5                  10                  15
Arg Lys Asp His Pro Phe Gly Phe Val Ala Val Pro Thr Lys Asn Pro 
             20                  25                  30
Asp Gly Thr Met Asn Leu Met Asn Trp Glu Cys Ala Ile Pro Gly Lys 
         35                  40                  45
Lys Gly Thr Pro Trp Glu Gly Gly Leu Phe Lys Leu Arg Met Leu Phe 
     50                  55                  60
Lys Asp Asp Tyr Pro Ser Ser Pro Pro Lys Cys Lys Phe Glu Pro Pro 
 65                  70                  75                  80
Leu Phe His Pro Asn Val Tyr Pro Ser Gly Thr Val Cys Leu Ser Ile 
                 85                  90                  95
Leu Glu Glu Asp Lys Asp Trp Arg Pro Ala Ile Thr Ile Lys Gln Ile 
             100                105                110
Leu Leu Gly Ile Gln Glu Leu Leu Asn Glu Pro Asn Ile Gln Asp Pro 
         115                120                125
Ala Gln Ala Glu Ala Tyr Thr Ile Tyr Cys Gln Asn Arg Val Glu Tyr 
     130                135                140
Glu Lys Arg Val Arg Ala Gln Ala Lys Lys Phe Ala Pro Ser 
 145                150                155



<210> 8680
<211> 1092
<212> DNA
<213> Rattus norvegicus
<308> U54632
<400> 8680

aggggaagt  ccgagacaa  ggagcgccg  cgcctctgc  gccgcgacg  tccgggccg  60
ggtcgccca  ggactttga  tatgtcggg  attgccctc  gccgacttg  gcaggagag  120
aaagcctgg  ggaaggacc  cccttttgg  tttgtggct  tcccaacaa  gaaccctga  180
ggcacgatg  acctgatga  ctgggagtg  gctatccct  gaaagaagg  gactccgtg  240
gaaggaggc  tgttcaagc  acggatgct  ttcaaagat  actatccgt  ctcaccacc  300
aaatgtaaa  ttgagccac  actgtttca  ccaaacgtg  atccttctg  cacagtgtg  360
ctgtccatc  tggaggaag  caaggactg  cggccagct  ttacgatca  acagatctt  420
ttaggaata  aagaacttc  aaatgaacc  aatattcaa  acccagctc  agcagaggc  480
tatacaatt  actgccaaa  cagagtgga  tatgagaaa  gggttcgag  acaagcgaa  540
aagtttgcc  cctcataag  agcggcccg  gctccatga  gaggaaggg  ttggcttgg  600
aagaacttg  ttacaacct  ttgcagatc  aagtcgctc  gtacagtta  tagtagcct  660
ggagggttg  gcgggcgcc  ttttccatt  ccgccactg  catattcag  cttttgtat  720
tttgattat  gagtaaaac  tgcttttat  ttaatattg  tgtcagtat  tcaactgct  780
taaaatgat  aacttttgt  cttggtaag  cctaggagc  agtttcttc  cgtccgctc  840
gatcgaggc  tgttcccca  tgttcagag  tctggcctc  agctggctg  atgacagaa  900
cacactgtc  ctccttcct  ccctaccct  gtccttctc  gaaacctgg  ctgttgctt  960
tgagcctca  atccaaagt  ggccagcat  tccattctg  accacttcc  ttgtgttta  1020
atggcgttt  gtctgtgtt  ctgtttaga  taaataaac  gtttatata  aaaaaaaaa  1080
aaaaaaaaa  aa  1092



<210> 8681
<211> 158
<212> PRT
<213> Rattus norvegicus
<308> P50550
<400> 8681

Met Ser Gly Ile Ala Leu Ser Arg Leu Ala Gln Glu Arg Lys Ala Trp 
  1               5                  10                  15
Arg Lys Asp His Pro Phe Gly Phe Val Ala Val Pro Thr Lys Asn Pro 
             20                  25                  30
Asp Gly Thr Met Asn Leu Met Asn Trp Glu Cys Ala Ile Pro Gly Lys 
         35                  40                  45
Lys Gly Thr Pro Trp Glu Gly Gly Leu Phe Lys Leu Arg Met Leu Phe 
     50                  55                  60
Lys Asp Asp Tyr Pro Ser Ser Pro Pro Lys Cys Lys Phe Glu Pro Pro 
 65                  70                  75                  80
Leu Phe His Pro Asn Val Tyr Pro Ser Gly Thr Val Cys Leu Ser Ile 
                 85                  90                  95
Leu Glu Glu Asp Lys Asp Trp Arg Pro Ala Ile Thr Ile Lys Gln Ile 
             100                105                110
Leu Leu Gly Ile Gln Glu Leu Leu Asn Glu Pro Asn Ile Gln Asp Pro 
         115                120                125
Ala Gln Ala Glu Ala Tyr Thr Ile Tyr Cys Gln Asn Arg Val Glu Tyr 
     130                135                140
Glu Lys Arg Val Arg Ala Gln Ala Lys Lys Phe Ala Pro Ser 
 145                150                155



<210> 8682
<211> 1077
<212> DNA
<213> Homo sapiens
<308> U29092
<400> 8682

aattcggca  gagggactt  gaacatgtc  gggatcgcc  tcagcagac  cgcccagga  60
aggaaagca  ggaggaaag  ccacccatt  ggtttcgtg  ctgtcccaa  aaaaaatcc  120
gatggcacg  tgaacctca  gaactggga  tgcgccatt  caggaaaga  agggactcc  180
tgggaagga  gcttgttta  actacggat  cttttcaaa  atgattatc  atcttcgcc  240
ccaaaatgt  aattcgaac  accattatt  cacccgaat  tgtaccctt  ggggacagt  300
tgcctgtcc  tcttagagg  ggacaagga  tggaggcca  ccatcacaa  caaacagat  360
ctattagga  tacaggaac  tctaaatga  ccaaatatc  aagacccag  tcaagcaga  420
gcctacacg  tttactgcc  aaacagagt  gagtacgag  aaagggtcc  agcacaagc  480
aagaagttt  cgccctcat  agcagcgac  ttgtggcat  gtcaaaagg  agggattgg  540
ttggcaaga  cttgtttac  acatttttg  aaatctaaa  ttgctccat  caatgacta  600
tcacctggg  gggttgggc  ggcgccatc  tccattgcc  ccgcgggtg  gcggtctcg  660
ttcgctgaa  tgcccgttt  catacaggg  ctcttcctt  ggtcttttg  atttttgat  720
gttatgtaa  actcgcttt  attttaata  tgatgtcag  atttcaact  ctgtaaaat  780
ataaacttt  atacttggg  aagtccccc  gggcgagtt  ctcgctctg  gatgcaggc  840
tgcttctca  cgtgcagag  tgcacttgg  ctcagctgg  tgtatggaa  tgcaccctc  900
ctcctgccg  tcctctcta  aaccttcta  aacctgggc  gtgctgctt  tgagcctca  960
accccaggg  agcatctcg  ttctgcgcc  cttcctttg  gttatatgg  gttttgtct  1020
tgttgctgt  tagagtaaa  aaactgttt  tataaaaaa  aaaaaaaaa  aactcga  1077



<210> 8683
<211> 158
<212> PRT
<213> Homo sapiens
<308> P50550
<400> 8683

Met Ser Gly Ile Ala Leu Ser Arg Leu Ala Gln Glu Arg Lys Ala Trp 
  1               5                  10                  15
Arg Lys Asp His Pro Phe Gly Phe Val Ala Val Pro Thr Lys Asn Pro 
             20                  25                  30
Asp Gly Thr Met Asn Leu Met Asn Trp Glu Cys Ala Ile Pro Gly Lys 
         35                  40                  45
Lys Gly Thr Pro Trp Glu Gly Gly Leu Phe Lys Leu Arg Met Leu Phe 
     50                  55                  60
Lys Asp Asp Tyr Pro Ser Ser Pro Pro Lys Cys Lys Phe Glu Pro Pro 
 65                  70                  75                  80
Leu Phe His Pro Asn Val Tyr Pro Ser Gly Thr Val Cys Leu Ser Ile 
                 85                  90                  95
Leu Glu Glu Asp Lys Asp Trp Arg Pro Ala Ile Thr Ile Lys Gln Ile 
             100                105                110
Leu Leu Gly Ile Gln Glu Leu Leu Asn Glu Pro Asn Ile Gln Asp Pro 
         115                120                125
Ala Gln Ala Glu Ala Tyr Thr Ile Tyr Cys Gln Asn Arg Val Glu Tyr 
     130                135                140
Glu Lys Arg Val Arg Ala Gln Ala Lys Lys Phe Ala Pro Ser 
 145                150                155



<210> 8684
<211> 3726
<212> DNA
<213> Rattus norvegicus
<308> U55815
<400> 8684

atgcctcac  tcaccgtgg  gccggtgga  gggccgcga  gcggcgact  tgacaacct  60
gaggggctc  gttgggtgg  ctacgggga  cgcgccgag  gggaagact  ggatggaca  120
ggtaaccac  gagagaata  tcccttcct  agccctttg  acgcctcca  aggaaatga  180
tactatgac  ggaacctgg  actgtttga  gaggagctg  acatccgcc  aaaggtatc  240
tctctcctg  gcaagcttg  cagctatac  aacctcacc  aaggagcca  ggagcacga  300
gaagctgag  gtggagaag  tggccgtcg  agagccgcc  aggcaccca  catgggcac  360
cttatggga  tgtacctgc  ctgcctgca  aatatcttc  gggtcatcc  cttcctgcg  420
ctgacctgg  tggtgggca  agctggcgt  ctgcaggct  tcctcattg  cctcatctg  480
tgctgctgt  ccctgctga  agccatctc  atgagtgcc  tcgccacca  tggtgtggt  540
ccagctggt  gctcttact  catgatttc  cgctctttg  gaccagaat  cggaggtgc  600
gtgggccta  gcttctacc  ggggaccac  tttgcagca  ccatgtata  cctaggagc  660
attgagatc  tgctgacct  cattgctcc  ccagctgcc  tcttttacc  atcgggcac  720
cacgacatg  caagcgcca  cttgaataa  atgcgggtg  acggaacca  tttcctgac  780
ttcatgacc  tagtggtgt  tgtcggtgt  aagtatgtg  acaagttcg  ctcactctt  840
ctggcctgt  tgatcatct  catcctctc  atttacgtg  gaggcatca  gtccgcttt  900
gaccctcct  tttttccgg  gtgcatgct  ggcaatagg  ctctgtctc  ggaccagtt  960
gacatctgt  ccaagacag  tgtggtgga  aatgagaca  tggccaccc  gctgtggac  1020
ttcttctgc  acagcccca  ccttactgc  gactcctgt  acccctact  cctgctcaa  1080
aatgtgaca  agattcctg  catacctgg  gcagctgct  gtgtgctcc  ggaaaacct  1140
tggagtgct  acctggaga  gggtgaggt  gtggagaag  atgggctgc  ctccacaga  1200
acccttggc  tgaaggaga  cctgtccct  tatgtggtg  ccgacatcg  cacatcctt  1260
accgtgctg  ttggcatct  tttcccttc  gtaacaggc  tcatggctg  ctcaaaccg  1320
tccggggac  tccgtgatg  tcagaagtc  atccctgtg  ggaccattc  ggctattgt  1380
accacttca  tcgtgtact  cagcagtgt  attctcttc  gtgcctgca  cgagggtgt  1440
gtgctccgg  acaagtacg  tgatggcgt  agcaggaac  tggtggtag  caccttggc  1500
tggccttca  cttgggtca  cgtggtcgg  tccttcttc  caacatgtg  tgccggcct  1560
caaagtctc  ctggggcgc  acgtttact  caagccatt  ccaaggata  catcatccc  1620
ttcctccgg  tgtttggcc  cgggaaagc  aatggtgag  caacgtggg  cctcctcct  1680
acagcgctc  tcgctgagc  gggcatcct  atcgcctcc  ttgacatgg  ggcccccat  1740
ctttccatg  tctttctga  gtgttacct  tttgtaaac  tggcctgtg  tgtgcagac  1800
cttctgagg  cccccaact  gcggccccg  ttcaagtac  atcactggg  gttgtcttt  1860
ctgggcatg  gtctgtgcc  ggctctcat  tttgtctcc  cctggtact  cgccctagt  1920
gccatggtc  tcgcaggca  gatctacaa  tacatcgag  accaagggg  tgagaagga  1980
tggggtgat  ggatccgag  cctgtccct  agtgccgca  gatatgcac  gctgagact  2040
gaggaaggg  ctcctcaca  gaagaactg  cggcctcag  tcctggtgc  gctgaagtt  2100
gacgaagat  ttcatgtga  gtaccctcg  ctcctcacc  ttgcctccc  acttaaggc  2160
gggaaaggc  tgacaatcg  tggctctgt  atccagggc  gctttctgg  gagctatgg  2220
gaagcccag  ctgctgagc  gacaatcaa  aacatgatg  agattgaga  agtaaaagg  2280
ttctgccag  tagtggtgg  cagcaaggt  cgagagggg  tggcccacc  catccagtc  2340
tgcggcctg  gtggcatga  acataactc  gtggtgctg  gctggccct  tggctggcg  2400
cagagtgag  acccacgtg  ctggaagac  tttatcgac  ctgtgcgct  caccacagc  2460
gcccacctg  ccctgctgg  gccaaagaa  atagctttc  accccagca  ccacgagcg  2520
tacctggag  gccacattg  tgtgtggtg  atcgtgcat  acggaggca  gctgatgct  2580
ctgcccttc  tgctgcgcc  gcataaggt  tggaagaag  gccggatgc  cattttcac  2640
gtggcccag  tggacgaca  cagcatcca  atgaagaag  atctggcca  cttcctgta  2700
cacctccgc  tggaagctg  agtggaggt  gtagagatg  acaacagtg  catctcggc  2760
tacacctac  agcggacac  gatgatgga  cagcggtct  aaatgctgc  acagatgag  2820
ctgaccaaa  cagagcggg  tcgagaggc  cagctggtg  aggacaggc  ctcggctct  2880
aggctagag  gcctctact  cgacgagga  gatgagtct  tgacaggcg  tgacaagat  2940
cagatgaca  ggaccagag  caagtacat  gctgaaccc  gggacccca  ccatgcccc  3000
gacaacttc  gggagctgg  gcacattaa  ccggaccag  ccaatgtgc  gcgtatgca  3060
actgctgtg  agctcaatg  agtcattgt  acacgctcc  atgatgccc  cctggtcct  3120
ctgaacatg  ccggccccc  taagaacag  gagggtgat  agaactaca  ggaattcct  3180
gaagtccta  ccgagggcc  tgaacgggt  ttgttggtg  gtggtggtg  ccgggaagt  3240
atcaccatc  attcttgag  ccgatggag  cttgtggcc  ggagttggg  tgtctaaga  3300
aacagtgcc  agccttgca  ctacttgcc  gttctgcct  gcccagcct  gctttggac  3360
agctttgct  ggtctccag  gaaaccaag  ttgggcctt  caatgggaa  ggatccgag  3420
gcccacggg  cctggagga  ttagggact  tcccctccc  tactccaag  gaggcctct  3480
ctgactcga  atgactggt  agggctgat  tgggatttg  agtcccaga  tggctcaca  3540
gtgctattt  ttgtatatt  attgtgtgg  tgtcatcat  tcagaaagg  gggagacaa  3600
aaaaggggg  gccgagctg  gcctgtctg  aggaagatc  ggctcaggc  gctgtgggc  3660
gcatcaagc  aagtggaat  gagctggcc  agctgagcc  gactttttt  aataaaacc  3720
cgtgcc  3726



<210> 8685
<211> 1085
<212> PRT
<213> Rattus norvegicus
<308> AAC52634
<400> 8685

Met Pro His Phe Thr Val Val Pro Val Asp Gly Pro Arg Arg Gly Asp 
  1               5                  10                  15
Tyr Asp Asn Leu Glu Gly Leu Ser Trp Val Asp Tyr Gly Glu Arg Ala 
             20                  25                  30
Glu Arg Glu Asp Ser Asp Gly Gln Gly Asn His Arg Glu Asn Ser Pro 
         35                  40                  45
Phe Leu Ser Pro Leu Asp Ala Ser Arg Gly Asn Asp Tyr Tyr Asp Arg 
     50                  55                  60
Asn Leu Ala Leu Phe Glu Glu Glu Leu Asp Ile Arg Pro Lys Val Ser 
 65                  70                  75                  80
Ser Leu Leu Gly Lys Leu Val Ser Tyr Thr Asn Leu Thr Gln Gly Ala 
                 85                  90                  95
Lys Glu His Glu Glu Ala Glu Ser Gly Glu Gly Gly Arg Arg Arg Ala 
             100                105                110
Ala Lys Ala Pro Ser Met Gly Thr Leu Met Gly Val Tyr Leu Pro Cys 
         115                120                125
Leu Gln Asn Ile Phe Gly Val Ile Leu Phe Leu Arg Leu Thr Trp Met 
     130                135                140
Val Gly Thr Ala Gly Val Leu Gln Ala Leu Leu Ile Val Leu Ile Cys 
 145                150                155                160
Cys Cys Cys Thr Leu Leu Thr Ala Ile Ser Met Ser Ala Ile Ala Thr 
                 165                170                175
Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Phe Met Ile Ser Arg Ser 
             180                185                190
Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly 
         195                200                205
Thr Thr Phe Ala Ala Ala Met Tyr Ile Leu Gly Ala Ile Glu Ile Leu 
     210                215                220
Leu Thr Tyr Ile Ala Pro Pro Ala Ala Ile Phe Tyr Pro Ser Gly Thr 
 225                230                235                240
His Asp Met Ser Ser Ala Thr Leu Asn Asn Met Arg Val Tyr Gly Thr 
                 245                250                255
Ile Phe Leu Thr Phe Met Thr Leu Val Val Phe Val Gly Val Lys Tyr 
             260                265                270
Val Asn Lys Phe Ala Ser Leu Phe Leu Ala Cys Val Ile Ile Ser Ile 
         275                280                285
Leu Ser Ile Tyr Val Gly Gly Ile Lys Ser Ala Phe Asp Pro Pro Val 
     290                295                300
Phe Pro Val Cys Met Leu Gly Asn Arg Thr Leu Ser Arg Asp Gln Phe 
 305                310                315                320
Asp Ile Cys Ala Lys Thr Val Val Val Asp Asn Glu Thr Val Ala Thr 
                 325                330                335
Arg Leu Trp Thr Phe Phe Cys His Ser Pro Asn Leu Thr Ala Asp Ser 
             340                345                350
Cys Asp Pro Tyr Phe Leu Leu Asn Asn Val Thr Glu Ile Pro Gly Ile 
         355                360                365
Pro Gly Ala Ala Ala Gly Val Leu Gln Glu Asn Leu Trp Ser Ala Tyr 
     370                375                380
Leu Glu Lys Gly Glu Val Val Glu Lys His Gly Leu Pro Ser Thr Asp 
 385                390                395                400
Thr Leu Gly Leu Lys Glu Ser Leu Ser Leu Tyr Val Val Ala Asp Ile 
                 405                410                415
Ala Thr Ser Phe Thr Val Leu Val Gly Ile Phe Phe Pro Ser Val Thr 
             420                425                430
Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Arg Asp Ala Gln 
         435                440                445
Lys Ser Ile Pro Val Gly Thr Ile Leu Ala Ile Val Thr Thr Ser Leu 
     450                455                460
Val Tyr Phe Ser Ser Val Ile Leu Phe Gly Ala Cys Ile Glu Gly Val 
 465                470                475                480
Val Leu Arg Asp Lys Tyr Gly Asp Gly Val Ser Arg Asn Leu Val Val 
                 485                490                495
Gly Thr Leu Ala Trp Pro Ser Pro Trp Val Ile Val Val Gly Ser Phe 
             500                505                510
Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg 
         515                520                525
Leu Leu Gln Ala Ile Ala Lys Asp Asn Ile Ile Pro Phe Leu Arg Val 
     530                535                540
Phe Gly His Gly Lys Ala Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu 
 545                550                555                560
Thr Ala Leu Ile Ala Glu Leu Gly Ile Leu Ile Ala Ser Leu Asp Met 
                 565                570                575
Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Leu Phe Val 
             580                585                590
Asn Leu Ala Cys Ala Val Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg 
         595                600                605
Pro Arg Phe Lys Tyr Tyr His Trp Ala Leu Ser Phe Leu Gly Met Ser 
     610                615                620
Leu Cys Leu Ala Leu Met Phe Val Ser Ser Trp Tyr Tyr Ala Leu Val 
 625                630                635                640
Ala Met Val Ile Ala Gly Met Ile Tyr Lys Tyr Ile Glu Tyr Gln Gly 
                 645                650                655
Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Ser Ala 
             660                665                670
Ala Arg Tyr Ala Leu Leu Arg Leu Glu Glu Gly Pro Pro His Thr Lys 
         675                680                685
Asn Trp Arg Pro Gln Leu Leu Val Leu Leu Lys Leu Asp Glu Asp Leu 
     690                695                700
His Val Lys Tyr Pro Arg Leu Leu Thr Phe Ala Ser Gln Leu Lys Ala 
 705                710                715                720
Gly Lys Gly Leu Thr Ile Val Gly Ser Val Ile Gln Gly Ser Phe Leu 
                 725                730                735
Glu Ser Tyr Gly Glu Ala Gln Ala Ala Glu Gln Thr Ile Lys Asn Met 
             740                745                750
Met Glu Ile Glu Lys Val Lys Gly Phe Cys Gln Val Val Val Ala Ser 
         755                760                765
Lys Val Arg Glu Gly Leu Ala His Leu Ile Gln Ser Cys Gly Leu Gly 
     770                775                780
Gly Met Arg His Asn Ser Val Val Leu Gly Trp Pro Tyr Gly Trp Arg 
 785                790                795                800
Gln Ser Glu Asp Pro Arg Ala Trp Lys Thr Phe Ile Asp Thr Val Arg 
                 805                810                815
Cys Thr Thr Ala Ala His Leu Ala Leu Leu Val Pro Lys Asn Ile Ala 
             820                825                830
Phe Tyr Pro Ser Asn His Glu Arg Tyr Leu Glu Gly His Ile Asp Val 
         835                840                845
Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu 
     850                855                860
Leu Arg Gln His Lys Val Trp Lys Lys Cys Arg Met Arg Ile Phe Thr 
 865                870                875                880
Val Ala Gln Met Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Ala 
                 885                890                895
Ile Phe Leu Tyr His Leu Arg Leu Glu Ala Glu Val Glu Val Val Glu 
             900                905                910
Met His Asn Ser Asp Ile Ser Ala Tyr Thr Tyr Glu Arg Thr Leu Met 
         915                920                925
Met Glu Gln Arg Ser Gln Met Leu Arg Gln Met Arg Leu Thr Lys Thr 
     930                935                940
Glu Arg Asp Arg Glu Ala Gln Leu Val Lys Asp Arg His Ser Ala Leu 
 945                950                955                960
Arg Leu Glu Ser Leu Tyr Ser Asp Glu Glu Asp Glu Ser Val Thr Gly 
                 965                970                975
Ala Asp Lys Ile Gln Met Thr Trp Thr Arg Asp Lys Tyr Met Ala Glu 
             980                985                990
Pro Trp Asp Pro Ser His Ala Pro Asp Asn Phe Arg Glu Leu Val His 
         995                1000                1005
Ile Lys Pro Asp Gln Ser Asn Val Arg Arg Met His Thr Ala Val Lys 
     1010                1015                1020
Leu Asn Glu Val Ile Val Thr Arg Ser His Asp Ala Arg Leu Val Leu 
 1025                1030                1035                1040
Leu Asn Met Pro Gly Pro Pro Lys Asn Ser Glu Gly Asp Glu Asn Tyr 
                 1045                1050                1055
Met Glu Phe Leu Glu Val Leu Thr Glu Gly Leu Glu Arg Val Leu Leu 
             1060                1065                1070
Val Arg Gly Gly Gly Arg Glu Val Ile Thr Ile Tyr Ser 
         1075                1080                1085



<210> 8686
<211> 4318
<212> DNA
<213> Homo sapiens
<308> AK024493
<400> 8686

gacatcccg  tctgcctcc  ggggaaccg  acgctgtca  ggcgcagct  cgatgcctg  60
gtcaaggcc  acggcatcc  caacaactc  gccacctcc  cgctctggg  cctcttctg  120
aacggctcc  agcccagcg  cgcctgtga  gagtacttc  tccagaaca  cgtcaccga  180
atccagggc  tcccgggcg  ggccagtgg  gtcttcctg  agaacctgt  gagtacgta  240
gcgcacgcg  gggcgtttg  ggagaagaa  ggtgtgccc  cggtgcccg  ggcagagga  300
agccgtgcc  gcgcactgc  ctacgtgct  accgacatc  cggcctcct  caccctgct  360
gttggcatc  acttcccct  cgtgaccgg  atcatggcg  gttcaaacc  gtccgggga  420
ctcaaggat  cacagaagt  catccccac  gggaccatc  tggccatag  gacgacgtc  480
ttcatctat  tctcctgca  tgtgctgtt  ggggcctgc  ttgaaggcg  ggtcttacg  540
gataagttc  gggaggccc  gcaggggaa  ctggtcatc  gcatgctgg  ctggccctc  600
ccctgggtc  tcgtcatcg  ctccttctt  tccacctgc  gtgccggcc  gcagagcct  660
acgggggca  cgcgcctac  gcaggccat  gcccgtgac  gcatcgtcc  cttcctgca  720
gtgtttggc  acgggaagg  caacgggga  cccacgtgg  cgctgctgc  gacagtcct  780
atctgcgag  ctggcatcc  catcgcctc  ctggacagc  tggccccga  cctctccat  840
ttcttcctc  tgtgctacc  gttcgtgaa  ctggcctgc  ccgtgcaga  cctgctacg  900
acccccaac  ggcgtccac  cttcaagtt  taccactgg  ccctgtcct  tctgggtat  960
agcctgtgc  tggcgctga  gttcatctg  tcctggtac  acgcgctgt  cgccatgct  1020
atcgctggc  gcatctaca  gtacatcga  taccgcggg  ccgagaagg  gtggggcga  1080
ggcatccgt  gcctatccc  gaacgccgc  cgctacgcc  tgctgcgcg  ggagcacgg  1140
cccccccac  ccaagaact  gaggcccca  gtgctggtg  tgctgaacc  ggacgcgga  1200
caggccgtg  agcaccccc  cctgctgtc  ttcacgtcg  agctgaagg  cggcaaggg  1260
ctgaccatc  tgggctcgg  gctggaggg  acgtacctg  acaagcaca  ggaggctca  1320
cgggccgag  agaacatac  gtccctaat  agcacagag  agaccaagg  cttctgcca  1380
ctggtggtc  cgtccagcc  gcgggatgg  atgtcccac  tgatccagt  ggccggcct  1440
ggcggcctg  agcacaaca  ggtgctcat  gcctggccc  catcctgga  gcaggagga  1500
aaccccttc  cctggaaga  ctttgtaga  accgtccgc  acaccaccg  cgcgcacca  1560
gctctgctg  tggccaaga  cgtcgactc  tttccgcaa  accaggagc  cttcggcgg  1620
ggccacatc  acgtgtggt  gatcgtgca  gacggcggc  tgctcatgc  gctgccctt  1680
ctgctgcgc  agcacaagg  gtggaggaa  tgccggatg  gtatcttca  cgtggccca  1740
gtggacgac  acagcatcc  gatgaagaa  gacctgcag  tgttcttgt  ccacttgcg  1800
atcagcgcc  aggtggagg  ggtggagat  gttgaaaac  acatatctg  tttcaccta  1860
gagaggaca  taatgatgg  gcagaggtc  cagatgctg  agcagatgc  gctgtccaa  1920
aacgagcag  agcgagagg  ccagctgat  cacgacagg  acaccgcgt  ccacaccgc  1980
gcggcagcc  ggacccaag  gccgcctac  ccagacaag  tgcagatga  ctggaccag  2040
gagaagctg  tcgctgaga  gtacaggag  agagacacc  gcctatctg  tttcaaaga  2100
ctcttcagc  tgaagccgg  ccagtccaa  gtcaggcgg  tgcacacgg  tgtgaagct  2160
aatggcgtc  tcctcaaca  gtcccagga  gcgcagctg  tcctgctca  catgccagg  2220
cctcccaaa  accggcagg  agacgagaa  tacatggag  ttcttgaag  cctgaccga  2280
gggctgaac  gagtcctcc  ggtcagggg  ggcggccgg  aggtgatca  catctactc  2340
taatgccca  cagcatcac  gcactctgg  acaggcacg  aggacggcg  gggcagcct  2400
ggcctgggc  tggcccagg  aaacagacg  cagacacac  tgtccccca  tgatgccac  2460
caagctgcc  atggggctt  ctacggaag  ttctaggcc  gtcacctag  gctctcctg  2520
tcagcctta  caggctcag  aaatcaggg  gtggctgga  gatttcctt  catctgagg  2580
cagacgctg  taccggagt  acctggacg  ggccagatc  tctcgcagg  cacaagaag  2640
cagtgagcc  ttgccttgg  ttctggaag  tcttttcct  ggctggatt  acccagtgg  2700
taggttgca  ttctacccc  tccagaaca  tcttggaag  gcacccgga  ctgaagctg  2760
ccctgatga  gaaggtgaa  cgtcagccc  ggccatggc  ccgctcagg  ccccggtca  2820
ctccgagtc  ctctgttcc  tgactgtct  tgtgtttct  tacctcaag  cactgaagc  2880
ggaggactc  gtccatgcc  gtgtcaccc  cgtgtggga  cctctgggc  cggcaggtc  2940
acatttcat  agctgaggc  tgggccagg  ccatctgga  agggaactc  gcttttcca  3000
aacgtggtg  atcatctgt  gggtgtgtg  tgaacacgt  cagttcatc  gggcctacg  3060
tccgggaag  ggcccccag  tgtggctct  ccatgccgg  ctgtgtttg  agctgtccg  3120
gtctccatc  acctttaga  aaccagcca  ttcttttca  aagcactga  agggcccag  3180
ccacagcca  aggtgcgat  agtgcctca  gcaggcaaa  gcactgaaa  ccaggggca  3240
acgcgcgca  agtgaacag  gagttcccc  gacagccca  gacagccag  actgccctc  3300
ccaccccac  ccaccccag  agcacggca  acagttcag  ctctgagct  gctcacacg  3360
gccatcccc  ccccggtgc  ccagggaag  aggacacgg  cccgacgtg  gaggtcctc  3420
ggcagcagt  gcgcctggt  tcaggtctg  ctggctgag  cccgggcgt  ccctgccat  3480
gcctgtgcc  tgcatggag  cggcggtgg  actgaagag  tagctttca  gggcccaac  3540
ctttgcact  cggctggct  tgagtttct  ctttgtagg  tgtggtcac  tttgcaggc  3600
gcgggcagt  gcaccgact  gggcctccc  ttctatgtg  catatttat  tatttaaac  3660
ccccaggga  ttacgtggt  acaaggttg  ccataaaga  gttgcttct  tatactaga  3720
gccccagat  gccaggcct  gggctacgt  tggcttgca  ggtctccca  gggaatcag  3780
cccatcaac  aagttcaaa  cggggcaga  gctgcactt  tgcccccag  tgtttctga  3840
gagccagac  agggctggc  ttgctgtag  gtgacggct  ctgcccaga  cgtgtccca  3900
acatcacag  ggggctcag  agttcccac  gcctctgcc  gccttggct  agcatgagt  3960
aagcagcaa  acgctcctc  atgtctgga  ggggccggc  ggtcctgtg  cccctgcac  4020
tggaggaga  caggctaga  gcacagcgg  cacatggtg  tggctctga  cgttggttg  4080
tggctggaa  acagccctg  ttctgaggg  cgctcagtt  tgcacacga  accacctcc  4140
gagggctca  ctctgcccc  gccctgggc  gcagcctct  cacgcaagc  ccaggcatc  4200
tttgtgttg  caactccgt  taaccagta  ctacagcca  ttacaattg  ctccgtttc  4260
ttttgtagg  ttccctgtc  gtctgtgtt  gtagaaaaa  aaaatccta  gaaatctg  4318



<210> 8687
<211> 1085
<212> PRT
<213> Homo sapiens
<308> NP_005063
<400> 8687

Met Pro His Phe Thr Val Val Pro Val Asp Gly Pro Arg Arg Gly Asp 
  1               5                  10                  15
Tyr Asp Asn Leu Glu Gly Leu Ser Trp Val Asp Tyr Gly Glu Arg Ala 
             20                  25                  30
Glu Leu Asp Asp Ser Asp Gly His Gly Asn His Arg Glu Ser Ser Pro 
         35                  40                  45
Phe Leu Ser Pro Leu Glu Ala Ser Arg Gly Ile Asp Tyr Tyr Asp Arg 
     50                  55                  60
Asn Leu Ala Leu Phe Glu Glu Glu Leu Asp Ile Arg Pro Lys Val Ser 
 65                  70                  75                  80
Ser Leu Leu Gly Lys Leu Val Ser Tyr Thr Asn Leu Thr Gln Gly Ala 
                 85                  90                  95
Lys Glu His Glu Glu Ala Glu Ser Gly Glu Gly Thr Arg Arg Arg Ala 
             100                105                110
Ala Glu Ala Pro Ser Met Gly Thr Leu Met Gly Val Tyr Leu Pro Cys 
         115                120                125
Leu Gln Asn Ile Phe Gly Val Ile Leu Phe Leu Arg Leu Thr Trp Met 
     130                135                140
Val Gly Thr Ala Gly Val Leu Gln Ala Leu Leu Ile Val Leu Ile Cys 
 145                150                155                160
Cys Cys Cys Thr Leu Leu Thr Ala Ile Ser Met Ser Ala Ile Ala Thr 
                 165                170                175
Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Phe Met Ile Ser Arg Ser 
             180                185                190
Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly 
         195                200                205
Thr Thr Phe Ala Ala Ala Met Tyr Ile Leu Gly Ala Ile Glu Ile Leu 
     210                215                220
Leu Thr Tyr Ile Ala Pro Pro Ala Ala Ile Phe Tyr Pro Ser Gly Ala 
 225                230                235                240
His Asp Thr Ser Asn Ala Thr Leu Asn Asn Met Arg Val Tyr Gly Thr 
                 245                250                255
Ile Phe Leu Thr Phe Met Thr Leu Val Val Phe Val Gly Val Lys Tyr 
             260                265                270
Val Asn Lys Phe Ala Ser Leu Phe Leu Ala Cys Val Ile Ile Ser Ile 
         275                280                285
Leu Ser Ile Tyr Ala Gly Gly Ile Lys Ser Ile Phe Asp Pro Pro Val 
     290                295                300
Phe Pro Val Cys Met Leu Gly Asn Arg Thr Leu Ser Arg Asp Gln Phe 
 305                310                315                320
Asp Ile Cys Ala Lys Thr Ala Val Val Asp Asn Glu Thr Val Ala Thr 
                 325                330                335
Gln Leu Trp Ser Phe Phe Cys His Ser Pro Asn Leu Thr Thr Asp Ser 
             340                345                350
Cys Asp Pro Tyr Phe Met Leu Asn Asn Val Thr Glu Ile Pro Gly Ile 
         355                360                365
Pro Gly Ala Ala Ala Gly Val Leu Gln Glu Asn Leu Trp Ser Ala Tyr 
     370                375                380
Leu Glu Lys Gly Asp Ile Val Glu Lys His Gly Leu Pro Ser Ala Asp 
 385                390                395                400
Ala Pro Ser Leu Lys Glu Ser Leu Pro Leu Tyr Val Val Ala Asp Ile 
                 405                410                415
Ala Thr Ser Phe Thr Val Leu Val Gly Ile Phe Phe Pro Ser Val Thr 
             420                425                430
Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Arg Asp Ala Gln 
         435                440                445
Lys Ser Ile Pro Val Gly Thr Ile Leu Ala Ile Ile Thr Thr Ser Leu 
     450                455                460
Val Tyr Phe Ser Ser Val Val Leu Phe Gly Ala Cys Ile Glu Gly Val 
 465                470                475                480
Val Leu Arg Asp Lys Tyr Gly Asp Gly Val Ser Arg Asn Leu Val Val 
                 485                490                495
Gly Thr Leu Ala Trp Pro Ser Pro Trp Val Ile Val Ile Gly Ser Phe 
             500                505                510
Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg 
         515                520                525
Leu Leu Gln Ala Ile Ala Lys Asp Asn Ile Ile Pro Phe Leu Arg Val 
     530                535                540
Phe Gly His Gly Lys Val Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu 
 545                550                555                560
Thr Ala Leu Ile Ala Glu Leu Gly Ile Leu Ile Ala Ser Leu Asp Met 
                 565                570                575
Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Leu Phe Val 
             580                585                590
Asn Leu Ala Cys Ala Val Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg 
         595                600                605
Pro Arg Phe Lys Tyr Tyr His Trp Ala Leu Ser Phe Leu Gly Met Ser 
     610                615                620
Leu Cys Leu Ala Leu Met Phe Val Ser Ser Trp Tyr Tyr Ala Leu Val 
 625                630                635                640
Ala Met Leu Ile Ala Gly Met Ile Tyr Lys Tyr Ile Glu Tyr Gln Gly 
                 645                650                655
Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Ser Ala 
             660                665                670
Ala Arg Tyr Ala Leu Leu Arg Leu Glu Glu Gly Pro Pro His Thr Lys 
         675                680                685
Asn Trp Arg Pro Gln Leu Leu Val Leu Leu Lys Leu Asp Glu Asp Leu 
     690                695                700
His Val Lys Tyr Pro Arg Leu Leu Thr Phe Ala Ser Gln Leu Lys Ala 
 705                710                715                720
Gly Lys Gly Leu Thr Ile Val Gly Ser Val Ile Gln Gly Ser Phe Leu 
                 725                730                735
Glu Ser Tyr Gly Glu Ala Gln Ala Ala Glu Gln Thr Ile Lys Asn Met 
             740                745                750
Met Glu Ile Glu Lys Val Lys Gly Phe Cys Gln Val Val Val Ala Ser 
         755                760                765
Lys Val Arg Glu Gly Leu Ala His Leu Ile Gln Ser Cys Gly Leu Gly 
     770                775                780
Gly Met Arg His Asn Ser Val Val Leu Gly Trp Pro Tyr Gly Trp Arg 
 785                790                795                800
Gln Ser Glu Asp Pro Arg Ala Trp Lys Thr Phe Ile Asp Thr Val Arg 
                 805                810                815
Cys Thr Thr Ala Ala His Leu Ala Leu Leu Val Pro Lys Asn Ile Ala 
             820                825                830
Phe Tyr Pro Ser Asn His Glu Arg Tyr Leu Glu Gly His Ile Asp Val 
         835                840                845
Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu 
     850                855                860
Leu Arg Gln His Lys Val Trp Arg Lys Cys Arg Met Arg Ile Phe Thr 
 865                870                875                880
Val Ala Gln Met Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Ala 
                 885                890                895
Val Phe Leu Tyr His Leu Arg Leu Glu Ala Glu Val Glu Val Val Glu 
             900                905                910
Met His Asn Ser Asp Ile Ser Ala Tyr Thr Tyr Glu Arg Thr Leu Met 
         915                920                925
Met Glu Gln Arg Ser Gln Met Leu Arg Gln Met Arg Leu Thr Lys Thr 
     930                935                940
Glu Arg Glu Arg Glu Ala Gln Leu Val Lys Asp Arg His Ser Ala Leu 
 945                950                955                960
Arg Leu Glu Ser Leu Tyr Ser Asp Glu Glu Asp Glu Ser Ala Val Gly 
                 965                970                975
Ala Asp Lys Ile Gln Met Thr Trp Thr Arg Asp Lys Tyr Met Thr Glu 
             980                985                990
Thr Trp Asp Pro Ser His Ala Pro Asp Asn Phe Arg Glu Leu Val His 
         995                1000                1005
Ile Lys Pro Asp Gln Ser Asn Val Arg Arg Met His Thr Ala Val Lys 
     1010                1015                1020
Leu Asn Glu Val Ile Val Thr Arg Ser His Asp Ala Arg Leu Val Leu 
 1025                1030                1035                1040
Leu Asn Met Pro Gly Pro Pro Arg Asn Ser Glu Gly Asp Glu Asn Tyr 
                 1045                1050                1055
Met Glu Phe Leu Glu Val Leu Thr Glu Gly Leu Glu Arg Val Leu Leu 
             1060                1065                1070
Val Arg Gly Gly Gly Arg Glu Val Ile Thr Ile Tyr Ser 
         1075                1080                1085



<210> 8688
<211> 3726
<212> DNA
<213> Rattus norvegicus
<308> U55815
<400> 8688

atgcctcac  tcaccgtgg  gccggtgga  gggccgcga  gcggcgact  tgacaacct  60
gaggggctc  gttgggtgg  ctacgggga  cgcgccgag  gggaagact  ggatggaca  120
ggtaaccac  gagagaata  tcccttcct  agccctttg  acgcctcca  aggaaatga  180
tactatgac  ggaacctgg  actgtttga  gaggagctg  acatccgcc  aaaggtatc  240
tctctcctg  gcaagcttg  cagctatac  aacctcacc  aaggagcca  ggagcacga  300
gaagctgag  gtggagaag  tggccgtcg  agagccgcc  aggcaccca  catgggcac  360
cttatggga  tgtacctgc  ctgcctgca  aatatcttc  gggtcatcc  cttcctgcg  420
ctgacctgg  tggtgggca  agctggcgt  ctgcaggct  tcctcattg  cctcatctg  480
tgctgctgt  ccctgctga  agccatctc  atgagtgcc  tcgccacca  tggtgtggt  540
ccagctggt  gctcttact  catgatttc  cgctctttg  gaccagaat  cggaggtgc  600
gtgggccta  gcttctacc  ggggaccac  tttgcagca  ccatgtata  cctaggagc  660
attgagatc  tgctgacct  cattgctcc  ccagctgcc  tcttttacc  atcgggcac  720
cacgacatg  caagcgcca  cttgaataa  atgcgggtg  acggaacca  tttcctgac  780
ttcatgacc  tagtggtgt  tgtcggtgt  aagtatgtg  acaagttcg  ctcactctt  840
ctggcctgt  tgatcatct  catcctctc  atttacgtg  gaggcatca  gtccgcttt  900
gaccctcct  tttttccgg  gtgcatgct  ggcaatagg  ctctgtctc  ggaccagtt  960
gacatctgt  ccaagacag  tgtggtgga  aatgagaca  tggccaccc  gctgtggac  1020
ttcttctgc  acagcccca  ccttactgc  gactcctgt  acccctact  cctgctcaa  1080
aatgtgaca  agattcctg  catacctgg  gcagctgct  gtgtgctcc  ggaaaacct  1140
tggagtgct  acctggaga  gggtgaggt  gtggagaag  atgggctgc  ctccacaga  1200
acccttggc  tgaaggaga  cctgtccct  tatgtggtg  ccgacatcg  cacatcctt  1260
accgtgctg  ttggcatct  tttcccttc  gtaacaggc  tcatggctg  ctcaaaccg  1320
tccggggac  tccgtgatg  tcagaagtc  atccctgtg  ggaccattc  ggctattgt  1380
accacttca  tcgtgtact  cagcagtgt  attctcttc  gtgcctgca  cgagggtgt  1440
gtgctccgg  acaagtacg  tgatggcgt  agcaggaac  tggtggtag  caccttggc  1500
tggccttca  cttgggtca  cgtggtcgg  tccttcttc  caacatgtg  tgccggcct  1560
caaagtctc  ctggggcgc  acgtttact  caagccatt  ccaaggata  catcatccc  1620
ttcctccgg  tgtttggcc  cgggaaagc  aatggtgag  caacgtggg  cctcctcct  1680
acagcgctc  tcgctgagc  gggcatcct  atcgcctcc  ttgacatgg  ggcccccat  1740
ctttccatg  tctttctga  gtgttacct  tttgtaaac  tggcctgtg  tgtgcagac  1800
cttctgagg  cccccaact  gcggccccg  ttcaagtac  atcactggg  gttgtcttt  1860
ctgggcatg  gtctgtgcc  ggctctcat  tttgtctcc  cctggtact  cgccctagt  1920
gccatggtc  tcgcaggca  gatctacaa  tacatcgag  accaagggg  tgagaagga  1980
tggggtgat  ggatccgag  cctgtccct  agtgccgca  gatatgcac  gctgagact  2040
gaggaaggg  ctcctcaca  gaagaactg  cggcctcag  tcctggtgc  gctgaagtt  2100
gacgaagat  ttcatgtga  gtaccctcg  ctcctcacc  ttgcctccc  acttaaggc  2160
gggaaaggc  tgacaatcg  tggctctgt  atccagggc  gctttctgg  gagctatgg  2220
gaagcccag  ctgctgagc  gacaatcaa  aacatgatg  agattgaga  agtaaaagg  2280
ttctgccag  tagtggtgg  cagcaaggt  cgagagggg  tggcccacc  catccagtc  2340
tgcggcctg  gtggcatga  acataactc  gtggtgctg  gctggccct  tggctggcg  2400
cagagtgag  acccacgtg  ctggaagac  tttatcgac  ctgtgcgct  caccacagc  2460
gcccacctg  ccctgctgg  gccaaagaa  atagctttc  accccagca  ccacgagcg  2520
tacctggag  gccacattg  tgtgtggtg  atcgtgcat  acggaggca  gctgatgct  2580
ctgcccttc  tgctgcgcc  gcataaggt  tggaagaag  gccggatgc  cattttcac  2640
gtggcccag  tggacgaca  cagcatcca  atgaagaag  atctggcca  cttcctgta  2700
cacctccgc  tggaagctg  agtggaggt  gtagagatg  acaacagtg  catctcggc  2760
tacacctac  agcggacac  gatgatgga  cagcggtct  aaatgctgc  acagatgag  2820
ctgaccaaa  cagagcggg  tcgagaggc  cagctggtg  aggacaggc  ctcggctct  2880
aggctagag  gcctctact  cgacgagga  gatgagtct  tgacaggcg  tgacaagat  2940
cagatgaca  ggaccagag  caagtacat  gctgaaccc  gggacccca  ccatgcccc  3000
gacaacttc  gggagctgg  gcacattaa  ccggaccag  ccaatgtgc  gcgtatgca  3060
actgctgtg  agctcaatg  agtcattgt  acacgctcc  atgatgccc  cctggtcct  3120
ctgaacatg  ccggccccc  taagaacag  gagggtgat  agaactaca  ggaattcct  3180
gaagtccta  ccgagggcc  tgaacgggt  ttgttggtg  gtggtggtg  ccgggaagt  3240
atcaccatc  attcttgag  ccgatggag  cttgtggcc  ggagttggg  tgtctaaga  3300
aacagtgcc  agccttgca  ctacttgcc  gttctgcct  gcccagcct  gctttggac  3360
agctttgct  ggtctccag  gaaaccaag  ttgggcctt  caatgggaa  ggatccgag  3420
gcccacggg  cctggagga  ttagggact  tcccctccc  tactccaag  gaggcctct  3480
ctgactcga  atgactggt  agggctgat  tgggatttg  agtcccaga  tggctcaca  3540
gtgctattt  ttgtatatt  attgtgtgg  tgtcatcat  tcagaaagg  gggagacaa  3600
aaaaggggg  gccgagctg  gcctgtctg  aggaagatc  ggctcaggc  gctgtgggc  3660
gcatcaagc  aagtggaat  gagctggcc  agctgagcc  gactttttt  aataaaacc  3720
cgtgcc  3726



<210> 8689
<211> 1085
<212> PRT
<213> Rattus norvegicus
<308> AAC52634
<400> 8689

Met Pro His Phe Thr Val Val Pro Val Asp Gly Pro Arg Arg Gly Asp 
  1               5                  10                  15
Tyr Asp Asn Leu Glu Gly Leu Ser Trp Val Asp Tyr Gly Glu Arg Ala 
             20                  25                  30
Glu Arg Glu Asp Ser Asp Gly Gln Gly Asn His Arg Glu Asn Ser Pro 
         35                  40                  45
Phe Leu Ser Pro Leu Asp Ala Ser Arg Gly Asn Asp Tyr Tyr Asp Arg 
     50                  55                  60
Asn Leu Ala Leu Phe Glu Glu Glu Leu Asp Ile Arg Pro Lys Val Ser 
 65                  70                  75                  80
Ser Leu Leu Gly Lys Leu Val Ser Tyr Thr Asn Leu Thr Gln Gly Ala 
                 85                  90                  95
Lys Glu His Glu Glu Ala Glu Ser Gly Glu Gly Gly Arg Arg Arg Ala 
             100                105                110
Ala Lys Ala Pro Ser Met Gly Thr Leu Met Gly Val Tyr Leu Pro Cys 
         115                120                125
Leu Gln Asn Ile Phe Gly Val Ile Leu Phe Leu Arg Leu Thr Trp Met 
     130                135                140
Val Gly Thr Ala Gly Val Leu Gln Ala Leu Leu Ile Val Leu Ile Cys 
 145                150                155                160
Cys Cys Cys Thr Leu Leu Thr Ala Ile Ser Met Ser Ala Ile Ala Thr 
                 165                170                175
Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Phe Met Ile Ser Arg Ser 
             180                185                190
Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly 
         195                200                205
Thr Thr Phe Ala Ala Ala Met Tyr Ile Leu Gly Ala Ile Glu Ile Leu 
     210                215                220
Leu Thr Tyr Ile Ala Pro Pro Ala Ala Ile Phe Tyr Pro Ser Gly Thr 
 225                230                235                240
His Asp Met Ser Ser Ala Thr Leu Asn Asn Met Arg Val Tyr Gly Thr 
                 245                250                255
Ile Phe Leu Thr Phe Met Thr Leu Val Val Phe Val Gly Val Lys Tyr 
             260                265                270
Val Asn Lys Phe Ala Ser Leu Phe Leu Ala Cys Val Ile Ile Ser Ile 
         275                280                285
Leu Ser Ile Tyr Val Gly Gly Ile Lys Ser Ala Phe Asp Pro Pro Val 
     290                295                300
Phe Pro Val Cys Met Leu Gly Asn Arg Thr Leu Ser Arg Asp Gln Phe 
 305                310                315                320
Asp Ile Cys Ala Lys Thr Val Val Val Asp Asn Glu Thr Val Ala Thr 
                 325                330                335
Arg Leu Trp Thr Phe Phe Cys His Ser Pro Asn Leu Thr Ala Asp Ser 
             340                345                350
Cys Asp Pro Tyr Phe Leu Leu Asn Asn Val Thr Glu Ile Pro Gly Ile 
         355                360                365
Pro Gly Ala Ala Ala Gly Val Leu Gln Glu Asn Leu Trp Ser Ala Tyr 
     370                375                380
Leu Glu Lys Gly Glu Val Val Glu Lys His Gly Leu Pro Ser Thr Asp 
 385                390                395                400
Thr Leu Gly Leu Lys Glu Ser Leu Ser Leu Tyr Val Val Ala Asp Ile 
                 405                410                415
Ala Thr Ser Phe Thr Val Leu Val Gly Ile Phe Phe Pro Ser Val Thr 
             420                425                430
Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Arg Asp Ala Gln 
         435                440                445
Lys Ser Ile Pro Val Gly Thr Ile Leu Ala Ile Val Thr Thr Ser Leu 
     450                455                460
Val Tyr Phe Ser Ser Val Ile Leu Phe Gly Ala Cys Ile Glu Gly Val 
 465                470                475                480
Val Leu Arg Asp Lys Tyr Gly Asp Gly Val Ser Arg Asn Leu Val Val 
                 485                490                495
Gly Thr Leu Ala Trp Pro Ser Pro Trp Val Ile Val Val Gly Ser Phe 
             500                505                510
Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg 
         515                520                525
Leu Leu Gln Ala Ile Ala Lys Asp Asn Ile Ile Pro Phe Leu Arg Val 
     530                535                540
Phe Gly His Gly Lys Ala Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu 
 545                550                555                560
Thr Ala Leu Ile Ala Glu Leu Gly Ile Leu Ile Ala Ser Leu Asp Met 
                 565                570                575
Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Leu Phe Val 
             580                585                590
Asn Leu Ala Cys Ala Val Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg 
         595                600                605
Pro Arg Phe Lys Tyr Tyr His Trp Ala Leu Ser Phe Leu Gly Met Ser 
     610                615                620
Leu Cys Leu Ala Leu Met Phe Val Ser Ser Trp Tyr Tyr Ala Leu Val 
 625                630                635                640
Ala Met Val Ile Ala Gly Met Ile Tyr Lys Tyr Ile Glu Tyr Gln Gly 
                 645                650                655
Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Ser Ala 
             660                665                670
Ala Arg Tyr Ala Leu Leu Arg Leu Glu Glu Gly Pro Pro His Thr Lys 
         675                680                685
Asn Trp Arg Pro Gln Leu Leu Val Leu Leu Lys Leu Asp Glu Asp Leu 
     690                695                700
His Val Lys Tyr Pro Arg Leu Leu Thr Phe Ala Ser Gln Leu Lys Ala 
 705                710                715                720
Gly Lys Gly Leu Thr Ile Val Gly Ser Val Ile Gln Gly Ser Phe Leu 
                 725                730                735
Glu Ser Tyr Gly Glu Ala Gln Ala Ala Glu Gln Thr Ile Lys Asn Met 
             740                745                750
Met Glu Ile Glu Lys Val Lys Gly Phe Cys Gln Val Val Val Ala Ser 
         755                760                765
Lys Val Arg Glu Gly Leu Ala His Leu Ile Gln Ser Cys Gly Leu Gly 
     770                775                780
Gly Met Arg His Asn Ser Val Val Leu Gly Trp Pro Tyr Gly Trp Arg 
 785                790                795                800
Gln Ser Glu Asp Pro Arg Ala Trp Lys Thr Phe Ile Asp Thr Val Arg 
                 805                810                815
Cys Thr Thr Ala Ala His Leu Ala Leu Leu Val Pro Lys Asn Ile Ala 
             820                825                830
Phe Tyr Pro Ser Asn His Glu Arg Tyr Leu Glu Gly His Ile Asp Val 
         835                840                845
Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu 
     850                855                860
Leu Arg Gln His Lys Val Trp Lys Lys Cys Arg Met Arg Ile Phe Thr 
 865                870                875                880
Val Ala Gln Met Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Ala 
                 885                890                895
Ile Phe Leu Tyr His Leu Arg Leu Glu Ala Glu Val Glu Val Val Glu 
             900                905                910
Met His Asn Ser Asp Ile Ser Ala Tyr Thr Tyr Glu Arg Thr Leu Met 
         915                920                925
Met Glu Gln Arg Ser Gln Met Leu Arg Gln Met Arg Leu Thr Lys Thr 
     930                935                940
Glu Arg Asp Arg Glu Ala Gln Leu Val Lys Asp Arg His Ser Ala Leu 
 945                950                955                960
Arg Leu Glu Ser Leu Tyr Ser Asp Glu Glu Asp Glu Ser Val Thr Gly 
                 965                970                975
Ala Asp Lys Ile Gln Met Thr Trp Thr Arg Asp Lys Tyr Met Ala Glu 
             980                985                990
Pro Trp Asp Pro Ser His Ala Pro Asp Asn Phe Arg Glu Leu Val His 
         995                1000                1005
Ile Lys Pro Asp Gln Ser Asn Val Arg Arg Met His Thr Ala Val Lys 
     1010                1015                1020
Leu Asn Glu Val Ile Val Thr Arg Ser His Asp Ala Arg Leu Val Leu 
 1025                1030                1035                1040
Leu Asn Met Pro Gly Pro Pro Lys Asn Ser Glu Gly Asp Glu Asn Tyr 
                 1045                1050                1055
Met Glu Phe Leu Glu Val Leu Thr Glu Gly Leu Glu Arg Val Leu Leu 
             1060                1065                1070
Val Arg Gly Gly Gly Arg Glu Val Ile Thr Ile Tyr Ser 
         1075                1080                1085



<210> 8690
<211> 4318
<212> DNA
<213> Homo sapiens
<308> AK024493
<400> 8690

gacatcccg  tctgcctcc  ggggaaccg  acgctgtca  ggcgcagct  cgatgcctg  60
gtcaaggcc  acggcatcc  caacaactc  gccacctcc  cgctctggg  cctcttctg  120
aacggctcc  agcccagcg  cgcctgtga  gagtacttc  tccagaaca  cgtcaccga  180
atccagggc  tcccgggcg  ggccagtgg  gtcttcctg  agaacctgt  gagtacgta  240
gcgcacgcg  gggcgtttg  ggagaagaa  ggtgtgccc  cggtgcccg  ggcagagga  300
agccgtgcc  gcgcactgc  ctacgtgct  accgacatc  cggcctcct  caccctgct  360
gttggcatc  acttcccct  cgtgaccgg  atcatggcg  gttcaaacc  gtccgggga  420
ctcaaggat  cacagaagt  catccccac  gggaccatc  tggccatag  gacgacgtc  480
ttcatctat  tctcctgca  tgtgctgtt  ggggcctgc  ttgaaggcg  ggtcttacg  540
gataagttc  gggaggccc  gcaggggaa  ctggtcatc  gcatgctgg  ctggccctc  600
ccctgggtc  tcgtcatcg  ctccttctt  tccacctgc  gtgccggcc  gcagagcct  660
acgggggca  cgcgcctac  gcaggccat  gcccgtgac  gcatcgtcc  cttcctgca  720
gtgtttggc  acgggaagg  caacgggga  cccacgtgg  cgctgctgc  gacagtcct  780
atctgcgag  ctggcatcc  catcgcctc  ctggacagc  tggccccga  cctctccat  840
ttcttcctc  tgtgctacc  gttcgtgaa  ctggcctgc  ccgtgcaga  cctgctacg  900
acccccaac  ggcgtccac  cttcaagtt  taccactgg  ccctgtcct  tctgggtat  960
agcctgtgc  tggcgctga  gttcatctg  tcctggtac  acgcgctgt  cgccatgct  1020
atcgctggc  gcatctaca  gtacatcga  taccgcggg  ccgagaagg  gtggggcga  1080
ggcatccgt  gcctatccc  gaacgccgc  cgctacgcc  tgctgcgcg  ggagcacgg  1140
cccccccac  ccaagaact  gaggcccca  gtgctggtg  tgctgaacc  ggacgcgga  1200
caggccgtg  agcaccccc  cctgctgtc  ttcacgtcg  agctgaagg  cggcaaggg  1260
ctgaccatc  tgggctcgg  gctggaggg  acgtacctg  acaagcaca  ggaggctca  1320
cgggccgag  agaacatac  gtccctaat  agcacagag  agaccaagg  cttctgcca  1380
ctggtggtc  cgtccagcc  gcgggatgg  atgtcccac  tgatccagt  ggccggcct  1440
ggcggcctg  agcacaaca  ggtgctcat  gcctggccc  catcctgga  gcaggagga  1500
aaccccttc  cctggaaga  ctttgtaga  accgtccgc  acaccaccg  cgcgcacca  1560
gctctgctg  tggccaaga  cgtcgactc  tttccgcaa  accaggagc  cttcggcgg  1620
ggccacatc  acgtgtggt  gatcgtgca  gacggcggc  tgctcatgc  gctgccctt  1680
ctgctgcgc  agcacaagg  gtggaggaa  tgccggatg  gtatcttca  cgtggccca  1740
gtggacgac  acagcatcc  gatgaagaa  gacctgcag  tgttcttgt  ccacttgcg  1800
atcagcgcc  aggtggagg  ggtggagat  gttgaaaac  acatatctg  tttcaccta  1860
gagaggaca  taatgatgg  gcagaggtc  cagatgctg  agcagatgc  gctgtccaa  1920
aacgagcag  agcgagagg  ccagctgat  cacgacagg  acaccgcgt  ccacaccgc  1980
gcggcagcc  ggacccaag  gccgcctac  ccagacaag  tgcagatga  ctggaccag  2040
gagaagctg  tcgctgaga  gtacaggag  agagacacc  gcctatctg  tttcaaaga  2100
ctcttcagc  tgaagccgg  ccagtccaa  gtcaggcgg  tgcacacgg  tgtgaagct  2160
aatggcgtc  tcctcaaca  gtcccagga  gcgcagctg  tcctgctca  catgccagg  2220
cctcccaaa  accggcagg  agacgagaa  tacatggag  ttcttgaag  cctgaccga  2280
gggctgaac  gagtcctcc  ggtcagggg  ggcggccgg  aggtgatca  catctactc  2340
taatgccca  cagcatcac  gcactctgg  acaggcacg  aggacggcg  gggcagcct  2400
ggcctgggc  tggcccagg  aaacagacg  cagacacac  tgtccccca  tgatgccac  2460
caagctgcc  atggggctt  ctacggaag  ttctaggcc  gtcacctag  gctctcctg  2520
tcagcctta  caggctcag  aaatcaggg  gtggctgga  gatttcctt  catctgagg  2580
cagacgctg  taccggagt  acctggacg  ggccagatc  tctcgcagg  cacaagaag  2640
cagtgagcc  ttgccttgg  ttctggaag  tcttttcct  ggctggatt  acccagtgg  2700
taggttgca  ttctacccc  tccagaaca  tcttggaag  gcacccgga  ctgaagctg  2760
ccctgatga  gaaggtgaa  cgtcagccc  ggccatggc  ccgctcagg  ccccggtca  2820
ctccgagtc  ctctgttcc  tgactgtct  tgtgtttct  tacctcaag  cactgaagc  2880
ggaggactc  gtccatgcc  gtgtcaccc  cgtgtggga  cctctgggc  cggcaggtc  2940
acatttcat  agctgaggc  tgggccagg  ccatctgga  agggaactc  gcttttcca  3000
aacgtggtg  atcatctgt  gggtgtgtg  tgaacacgt  cagttcatc  gggcctacg  3060
tccgggaag  ggcccccag  tgtggctct  ccatgccgg  ctgtgtttg  agctgtccg  3120
gtctccatc  acctttaga  aaccagcca  ttcttttca  aagcactga  agggcccag  3180
ccacagcca  aggtgcgat  agtgcctca  gcaggcaaa  gcactgaaa  ccaggggca  3240
acgcgcgca  agtgaacag  gagttcccc  gacagccca  gacagccag  actgccctc  3300
ccaccccac  ccaccccag  agcacggca  acagttcag  ctctgagct  gctcacacg  3360
gccatcccc  ccccggtgc  ccagggaag  aggacacgg  cccgacgtg  gaggtcctc  3420
ggcagcagt  gcgcctggt  tcaggtctg  ctggctgag  cccgggcgt  ccctgccat  3480
gcctgtgcc  tgcatggag  cggcggtgg  actgaagag  tagctttca  gggcccaac  3540
ctttgcact  cggctggct  tgagtttct  ctttgtagg  tgtggtcac  tttgcaggc  3600
gcgggcagt  gcaccgact  gggcctccc  ttctatgtg  catatttat  tatttaaac  3660
ccccaggga  ttacgtggt  acaaggttg  ccataaaga  gttgcttct  tatactaga  3720
gccccagat  gccaggcct  gggctacgt  tggcttgca  ggtctccca  gggaatcag  3780
cccatcaac  aagttcaaa  cggggcaga  gctgcactt  tgcccccag  tgtttctga  3840
gagccagac  agggctggc  ttgctgtag  gtgacggct  ctgcccaga  cgtgtccca  3900
acatcacag  ggggctcag  agttcccac  gcctctgcc  gccttggct  agcatgagt  3960
aagcagcaa  acgctcctc  atgtctgga  ggggccggc  ggtcctgtg  cccctgcac  4020
tggaggaga  caggctaga  gcacagcgg  cacatggtg  tggctctga  cgttggttg  4080
tggctggaa  acagccctg  ttctgaggg  cgctcagtt  tgcacacga  accacctcc  4140
gagggctca  ctctgcccc  gccctgggc  gcagcctct  cacgcaagc  ccaggcatc  4200
tttgtgttg  caactccgt  taaccagta  ctacagcca  ttacaattg  ctccgtttc  4260
ttttgtagg  ttccctgtc  gtctgtgtt  gtagaaaaa  aaaatccta  gaaatctg  4318



<210> 8691
<211> 1085
<212> PRT
<213> Homo sapiens
<308> NP_005063
<400> 8691

Met Pro His Phe Thr Val Val Pro Val Asp Gly Pro Arg Arg Gly Asp 
  1               5                  10                  15
Tyr Asp Asn Leu Glu Gly Leu Ser Trp Val Asp Tyr Gly Glu Arg Ala 
             20                  25                  30
Glu Leu Asp Asp Ser Asp Gly His Gly Asn His Arg Glu Ser Ser Pro 
         35                  40                  45
Phe Leu Ser Pro Leu Glu Ala Ser Arg Gly Ile Asp Tyr Tyr Asp Arg 
     50                  55                  60
Asn Leu Ala Leu Phe Glu Glu Glu Leu Asp Ile Arg Pro Lys Val Ser 
 65                  70                  75                  80
Ser Leu Leu Gly Lys Leu Val Ser Tyr Thr Asn Leu Thr Gln Gly Ala 
                 85                  90                  95
Lys Glu His Glu Glu Ala Glu Ser Gly Glu Gly Thr Arg Arg Arg Ala 
             100                105                110
Ala Glu Ala Pro Ser Met Gly Thr Leu Met Gly Val Tyr Leu Pro Cys 
         115                120                125
Leu Gln Asn Ile Phe Gly Val Ile Leu Phe Leu Arg Leu Thr Trp Met 
     130                135                140
Val Gly Thr Ala Gly Val Leu Gln Ala Leu Leu Ile Val Leu Ile Cys 
 145                150                155                160
Cys Cys Cys Thr Leu Leu Thr Ala Ile Ser Met Ser Ala Ile Ala Thr 
                 165                170                175
Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Phe Met Ile Ser Arg Ser 
             180                185                190
Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly 
         195                200                205
Thr Thr Phe Ala Ala Ala Met Tyr Ile Leu Gly Ala Ile Glu Ile Leu 
     210                215                220
Leu Thr Tyr Ile Ala Pro Pro Ala Ala Ile Phe Tyr Pro Ser Gly Ala 
 225                230                235                240
His Asp Thr Ser Asn Ala Thr Leu Asn Asn Met Arg Val Tyr Gly Thr 
                 245                250                255
Ile Phe Leu Thr Phe Met Thr Leu Val Val Phe Val Gly Val Lys Tyr 
             260                265                270
Val Asn Lys Phe Ala Ser Leu Phe Leu Ala Cys Val Ile Ile Ser Ile 
         275                280                285
Leu Ser Ile Tyr Ala Gly Gly Ile Lys Ser Ile Phe Asp Pro Pro Val 
     290                295                300
Phe Pro Val Cys Met Leu Gly Asn Arg Thr Leu Ser Arg Asp Gln Phe 
 305                310                315                320
Asp Ile Cys Ala Lys Thr Ala Val Val Asp Asn Glu Thr Val Ala Thr 
                 325                330                335
Gln Leu Trp Ser Phe Phe Cys His Ser Pro Asn Leu Thr Thr Asp Ser 
             340                345                350
Cys Asp Pro Tyr Phe Met Leu Asn Asn Val Thr Glu Ile Pro Gly Ile 
         355                360                365
Pro Gly Ala Ala Ala Gly Val Leu Gln Glu Asn Leu Trp Ser Ala Tyr 
     370                375                380
Leu Glu Lys Gly Asp Ile Val Glu Lys His Gly Leu Pro Ser Ala Asp 
 385                390                395                400
Ala Pro Ser Leu Lys Glu Ser Leu Pro Leu Tyr Val Val Ala Asp Ile 
                 405                410                415
Ala Thr Ser Phe Thr Val Leu Val Gly Ile Phe Phe Pro Ser Val Thr 
             420                425                430
Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Arg Asp Ala Gln 
         435                440                445
Lys Ser Ile Pro Val Gly Thr Ile Leu Ala Ile Ile Thr Thr Ser Leu 
     450                455                460
Val Tyr Phe Ser Ser Val Val Leu Phe Gly Ala Cys Ile Glu Gly Val 
 465                470                475                480
Val Leu Arg Asp Lys Tyr Gly Asp Gly Val Ser Arg Asn Leu Val Val 
                 485                490                495
Gly Thr Leu Ala Trp Pro Ser Pro Trp Val Ile Val Ile Gly Ser Phe 
             500                505                510
Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg 
         515                520                525
Leu Leu Gln Ala Ile Ala Lys Asp Asn Ile Ile Pro Phe Leu Arg Val 
     530                535                540
Phe Gly His Gly Lys Val Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu 
 545                550                555                560
Thr Ala Leu Ile Ala Glu Leu Gly Ile Leu Ile Ala Ser Leu Asp Met 
                 565                570                575
Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Leu Phe Val 
             580                585                590
Asn Leu Ala Cys Ala Val Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg 
         595                600                605
Pro Arg Phe Lys Tyr Tyr His Trp Ala Leu Ser Phe Leu Gly Met Ser 
     610                615                620
Leu Cys Leu Ala Leu Met Phe Val Ser Ser Trp Tyr Tyr Ala Leu Val 
 625                630                635                640
Ala Met Leu Ile Ala Gly Met Ile Tyr Lys Tyr Ile Glu Tyr Gln Gly 
                 645                650                655
Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Ser Ala 
             660                665                670
Ala Arg Tyr Ala Leu Leu Arg Leu Glu Glu Gly Pro Pro His Thr Lys 
         675                680                685
Asn Trp Arg Pro Gln Leu Leu Val Leu Leu Lys Leu Asp Glu Asp Leu 
     690                695                700
His Val Lys Tyr Pro Arg Leu Leu Thr Phe Ala Ser Gln Leu Lys Ala 
 705                710                715                720
Gly Lys Gly Leu Thr Ile Val Gly Ser Val Ile Gln Gly Ser Phe Leu 
                 725                730                735
Glu Ser Tyr Gly Glu Ala Gln Ala Ala Glu Gln Thr Ile Lys Asn Met 
             740                745                750
Met Glu Ile Glu Lys Val Lys Gly Phe Cys Gln Val Val Val Ala Ser 
         755                760                765
Lys Val Arg Glu Gly Leu Ala His Leu Ile Gln Ser Cys Gly Leu Gly 
     770                775                780
Gly Met Arg His Asn Ser Val Val Leu Gly Trp Pro Tyr Gly Trp Arg 
 785                790                795                800
Gln Ser Glu Asp Pro Arg Ala Trp Lys Thr Phe Ile Asp Thr Val Arg 
                 805                810                815
Cys Thr Thr Ala Ala His Leu Ala Leu Leu Val Pro Lys Asn Ile Ala 
             820                825                830
Phe Tyr Pro Ser Asn His Glu Arg Tyr Leu Glu Gly His Ile Asp Val 
         835                840                845
Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu 
     850                855                860
Leu Arg Gln His Lys Val Trp Arg Lys Cys Arg Met Arg Ile Phe Thr 
 865                870                875                880
Val Ala Gln Met Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Ala 
                 885                890                895
Val Phe Leu Tyr His Leu Arg Leu Glu Ala Glu Val Glu Val Val Glu 
             900                905                910
Met His Asn Ser Asp Ile Ser Ala Tyr Thr Tyr Glu Arg Thr Leu Met 
         915                920                925
Met Glu Gln Arg Ser Gln Met Leu Arg Gln Met Arg Leu Thr Lys Thr 
     930                935                940
Glu Arg Glu Arg Glu Ala Gln Leu Val Lys Asp Arg His Ser Ala Leu 
 945                950                955                960
Arg Leu Glu Ser Leu Tyr Ser Asp Glu Glu Asp Glu Ser Ala Val Gly 
                 965                970                975
Ala Asp Lys Ile Gln Met Thr Trp Thr Arg Asp Lys Tyr Met Thr Glu 
             980                985                990
Thr Trp Asp Pro Ser His Ala Pro Asp Asn Phe Arg Glu Leu Val His 
         995                1000                1005
Ile Lys Pro Asp Gln Ser Asn Val Arg Arg Met His Thr Ala Val Lys 
     1010                1015                1020
Leu Asn Glu Val Ile Val Thr Arg Ser His Asp Ala Arg Leu Val Leu 
 1025                1030                1035                1040
Leu Asn Met Pro Gly Pro Pro Arg Asn Ser Glu Gly Asp Glu Asn Tyr 
                 1045                1050                1055
Met Glu Phe Leu Glu Val Leu Thr Glu Gly Leu Glu Arg Val Leu Leu 
             1060                1065                1070
Val Arg Gly Gly Gly Arg Glu Val Ile Thr Ile Tyr Ser 
         1075                1080                1085



<210> 8692
<211> 3726
<212> DNA
<213> Rattus norvegicus
<308> U55815
<400> 8692

atgcctcac  tcaccgtgg  gccggtgga  gggccgcga  gcggcgact  tgacaacct  60
gaggggctc  gttgggtgg  ctacgggga  cgcgccgag  gggaagact  ggatggaca  120
ggtaaccac  gagagaata  tcccttcct  agccctttg  acgcctcca  aggaaatga  180
tactatgac  ggaacctgg  actgtttga  gaggagctg  acatccgcc  aaaggtatc  240
tctctcctg  gcaagcttg  cagctatac  aacctcacc  aaggagcca  ggagcacga  300
gaagctgag  gtggagaag  tggccgtcg  agagccgcc  aggcaccca  catgggcac  360
cttatggga  tgtacctgc  ctgcctgca  aatatcttc  gggtcatcc  cttcctgcg  420
ctgacctgg  tggtgggca  agctggcgt  ctgcaggct  tcctcattg  cctcatctg  480
tgctgctgt  ccctgctga  agccatctc  atgagtgcc  tcgccacca  tggtgtggt  540
ccagctggt  gctcttact  catgatttc  cgctctttg  gaccagaat  cggaggtgc  600
gtgggccta  gcttctacc  ggggaccac  tttgcagca  ccatgtata  cctaggagc  660
attgagatc  tgctgacct  cattgctcc  ccagctgcc  tcttttacc  atcgggcac  720
cacgacatg  caagcgcca  cttgaataa  atgcgggtg  acggaacca  tttcctgac  780
ttcatgacc  tagtggtgt  tgtcggtgt  aagtatgtg  acaagttcg  ctcactctt  840
ctggcctgt  tgatcatct  catcctctc  atttacgtg  gaggcatca  gtccgcttt  900
gaccctcct  tttttccgg  gtgcatgct  ggcaatagg  ctctgtctc  ggaccagtt  960
gacatctgt  ccaagacag  tgtggtgga  aatgagaca  tggccaccc  gctgtggac  1020
ttcttctgc  acagcccca  ccttactgc  gactcctgt  acccctact  cctgctcaa  1080
aatgtgaca  agattcctg  catacctgg  gcagctgct  gtgtgctcc  ggaaaacct  1140
tggagtgct  acctggaga  gggtgaggt  gtggagaag  atgggctgc  ctccacaga  1200
acccttggc  tgaaggaga  cctgtccct  tatgtggtg  ccgacatcg  cacatcctt  1260
accgtgctg  ttggcatct  tttcccttc  gtaacaggc  tcatggctg  ctcaaaccg  1320
tccggggac  tccgtgatg  tcagaagtc  atccctgtg  ggaccattc  ggctattgt  1380
accacttca  tcgtgtact  cagcagtgt  attctcttc  gtgcctgca  cgagggtgt  1440
gtgctccgg  acaagtacg  tgatggcgt  agcaggaac  tggtggtag  caccttggc  1500
tggccttca  cttgggtca  cgtggtcgg  tccttcttc  caacatgtg  tgccggcct  1560
caaagtctc  ctggggcgc  acgtttact  caagccatt  ccaaggata  catcatccc  1620
ttcctccgg  tgtttggcc  cgggaaagc  aatggtgag  caacgtggg  cctcctcct  1680
acagcgctc  tcgctgagc  gggcatcct  atcgcctcc  ttgacatgg  ggcccccat  1740
ctttccatg  tctttctga  gtgttacct  tttgtaaac  tggcctgtg  tgtgcagac  1800
cttctgagg  cccccaact  gcggccccg  ttcaagtac  atcactggg  gttgtcttt  1860
ctgggcatg  gtctgtgcc  ggctctcat  tttgtctcc  cctggtact  cgccctagt  1920
gccatggtc  tcgcaggca  gatctacaa  tacatcgag  accaagggg  tgagaagga  1980
tggggtgat  ggatccgag  cctgtccct  agtgccgca  gatatgcac  gctgagact  2040
gaggaaggg  ctcctcaca  gaagaactg  cggcctcag  tcctggtgc  gctgaagtt  2100
gacgaagat  ttcatgtga  gtaccctcg  ctcctcacc  ttgcctccc  acttaaggc  2160
gggaaaggc  tgacaatcg  tggctctgt  atccagggc  gctttctgg  gagctatgg  2220
gaagcccag  ctgctgagc  gacaatcaa  aacatgatg  agattgaga  agtaaaagg  2280
ttctgccag  tagtggtgg  cagcaaggt  cgagagggg  tggcccacc  catccagtc  2340
tgcggcctg  gtggcatga  acataactc  gtggtgctg  gctggccct  tggctggcg  2400
cagagtgag  acccacgtg  ctggaagac  tttatcgac  ctgtgcgct  caccacagc  2460
gcccacctg  ccctgctgg  gccaaagaa  atagctttc  accccagca  ccacgagcg  2520
tacctggag  gccacattg  tgtgtggtg  atcgtgcat  acggaggca  gctgatgct  2580
ctgcccttc  tgctgcgcc  gcataaggt  tggaagaag  gccggatgc  cattttcac  2640
gtggcccag  tggacgaca  cagcatcca  atgaagaag  atctggcca  cttcctgta  2700
cacctccgc  tggaagctg  agtggaggt  gtagagatg  acaacagtg  catctcggc  2760
tacacctac  agcggacac  gatgatgga  cagcggtct  aaatgctgc  acagatgag  2820
ctgaccaaa  cagagcggg  tcgagaggc  cagctggtg  aggacaggc  ctcggctct  2880
aggctagag  gcctctact  cgacgagga  gatgagtct  tgacaggcg  tgacaagat  2940
cagatgaca  ggaccagag  caagtacat  gctgaaccc  gggacccca  ccatgcccc  3000
gacaacttc  gggagctgg  gcacattaa  ccggaccag  ccaatgtgc  gcgtatgca  3060
actgctgtg  agctcaatg  agtcattgt  acacgctcc  atgatgccc  cctggtcct  3120
ctgaacatg  ccggccccc  taagaacag  gagggtgat  agaactaca  ggaattcct  3180
gaagtccta  ccgagggcc  tgaacgggt  ttgttggtg  gtggtggtg  ccgggaagt  3240
atcaccatc  attcttgag  ccgatggag  cttgtggcc  ggagttggg  tgtctaaga  3300
aacagtgcc  agccttgca  ctacttgcc  gttctgcct  gcccagcct  gctttggac  3360
agctttgct  ggtctccag  gaaaccaag  ttgggcctt  caatgggaa  ggatccgag  3420
gcccacggg  cctggagga  ttagggact  tcccctccc  tactccaag  gaggcctct  3480
ctgactcga  atgactggt  agggctgat  tgggatttg  agtcccaga  tggctcaca  3540
gtgctattt  ttgtatatt  attgtgtgg  tgtcatcat  tcagaaagg  gggagacaa  3600
aaaaggggg  gccgagctg  gcctgtctg  aggaagatc  ggctcaggc  gctgtgggc  3660
gcatcaagc  aagtggaat  gagctggcc  agctgagcc  gactttttt  aataaaacc  3720
cgtgcc  3726



<210> 8693
<211> 1085
<212> PRT
<213> Rattus norvegicus
<308> AAC52634
<400> 8693

Met Pro His Phe Thr Val Val Pro Val Asp Gly Pro Arg Arg Gly Asp 
  1               5                  10                  15
Tyr Asp Asn Leu Glu Gly Leu Ser Trp Val Asp Tyr Gly Glu Arg Ala 
             20                  25                  30
Glu Arg Glu Asp Ser Asp Gly Gln Gly Asn His Arg Glu Asn Ser Pro 
         35                  40                  45
Phe Leu Ser Pro Leu Asp Ala Ser Arg Gly Asn Asp Tyr Tyr Asp Arg 
     50                  55                  60
Asn Leu Ala Leu Phe Glu Glu Glu Leu Asp Ile Arg Pro Lys Val Ser 
 65                  70                  75                  80
Ser Leu Leu Gly Lys Leu Val Ser Tyr Thr Asn Leu Thr Gln Gly Ala 
                 85                  90                  95
Lys Glu His Glu Glu Ala Glu Ser Gly Glu Gly Gly Arg Arg Arg Ala 
             100                105                110
Ala Lys Ala Pro Ser Met Gly Thr Leu Met Gly Val Tyr Leu Pro Cys 
         115                120                125
Leu Gln Asn Ile Phe Gly Val Ile Leu Phe Leu Arg Leu Thr Trp Met 
     130                135                140
Val Gly Thr Ala Gly Val Leu Gln Ala Leu Leu Ile Val Leu Ile Cys 
 145                150                155                160
Cys Cys Cys Thr Leu Leu Thr Ala Ile Ser Met Ser Ala Ile Ala Thr 
                 165                170                175
Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Phe Met Ile Ser Arg Ser 
             180                185                190
Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly 
         195                200                205
Thr Thr Phe Ala Ala Ala Met Tyr Ile Leu Gly Ala Ile Glu Ile Leu 
     210                215                220
Leu Thr Tyr Ile Ala Pro Pro Ala Ala Ile Phe Tyr Pro Ser Gly Thr 
 225                230                235                240
His Asp Met Ser Ser Ala Thr Leu Asn Asn Met Arg Val Tyr Gly Thr 
                 245                250                255
Ile Phe Leu Thr Phe Met Thr Leu Val Val Phe Val Gly Val Lys Tyr 
             260                265                270
Val Asn Lys Phe Ala Ser Leu Phe Leu Ala Cys Val Ile Ile Ser Ile 
         275                280                285
Leu Ser Ile Tyr Val Gly Gly Ile Lys Ser Ala Phe Asp Pro Pro Val 
     290                295                300
Phe Pro Val Cys Met Leu Gly Asn Arg Thr Leu Ser Arg Asp Gln Phe 
 305                310                315                320
Asp Ile Cys Ala Lys Thr Val Val Val Asp Asn Glu Thr Val Ala Thr 
                 325                330                335
Arg Leu Trp Thr Phe Phe Cys His Ser Pro Asn Leu Thr Ala Asp Ser 
             340                345                350
Cys Asp Pro Tyr Phe Leu Leu Asn Asn Val Thr Glu Ile Pro Gly Ile 
         355                360                365
Pro Gly Ala Ala Ala Gly Val Leu Gln Glu Asn Leu Trp Ser Ala Tyr 
     370                375                380
Leu Glu Lys Gly Glu Val Val Glu Lys His Gly Leu Pro Ser Thr Asp 
 385                390                395                400
Thr Leu Gly Leu Lys Glu Ser Leu Ser Leu Tyr Val Val Ala Asp Ile 
                 405                410                415
Ala Thr Ser Phe Thr Val Leu Val Gly Ile Phe Phe Pro Ser Val Thr 
             420                425                430
Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Arg Asp Ala Gln 
         435                440                445
Lys Ser Ile Pro Val Gly Thr Ile Leu Ala Ile Val Thr Thr Ser Leu 
     450                455                460
Val Tyr Phe Ser Ser Val Ile Leu Phe Gly Ala Cys Ile Glu Gly Val 
 465                470                475                480
Val Leu Arg Asp Lys Tyr Gly Asp Gly Val Ser Arg Asn Leu Val Val 
                 485                490                495
Gly Thr Leu Ala Trp Pro Ser Pro Trp Val Ile Val Val Gly Ser Phe 
             500                505                510
Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg 
         515                520                525
Leu Leu Gln Ala Ile Ala Lys Asp Asn Ile Ile Pro Phe Leu Arg Val 
     530                535                540
Phe Gly His Gly Lys Ala Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu 
 545                550                555                560
Thr Ala Leu Ile Ala Glu Leu Gly Ile Leu Ile Ala Ser Leu Asp Met 
                 565                570                575
Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Leu Phe Val 
             580                585                590
Asn Leu Ala Cys Ala Val Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg 
         595                600                605
Pro Arg Phe Lys Tyr Tyr His Trp Ala Leu Ser Phe Leu Gly Met Ser 
     610                615                620
Leu Cys Leu Ala Leu Met Phe Val Ser Ser Trp Tyr Tyr Ala Leu Val 
 625                630                635                640
Ala Met Val Ile Ala Gly Met Ile Tyr Lys Tyr Ile Glu Tyr Gln Gly 
                 645                650                655
Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Ser Ala 
             660                665                670
Ala Arg Tyr Ala Leu Leu Arg Leu Glu Glu Gly Pro Pro His Thr Lys 
         675                680                685
Asn Trp Arg Pro Gln Leu Leu Val Leu Leu Lys Leu Asp Glu Asp Leu 
     690                695                700
His Val Lys Tyr Pro Arg Leu Leu Thr Phe Ala Ser Gln Leu Lys Ala 
 705                710                715                720
Gly Lys Gly Leu Thr Ile Val Gly Ser Val Ile Gln Gly Ser Phe Leu 
                 725                730                735
Glu Ser Tyr Gly Glu Ala Gln Ala Ala Glu Gln Thr Ile Lys Asn Met 
             740                745                750
Met Glu Ile Glu Lys Val Lys Gly Phe Cys Gln Val Val Val Ala Ser 
         755                760                765
Lys Val Arg Glu Gly Leu Ala His Leu Ile Gln Ser Cys Gly Leu Gly 
     770                775                780
Gly Met Arg His Asn Ser Val Val Leu Gly Trp Pro Tyr Gly Trp Arg 
 785                790                795                800
Gln Ser Glu Asp Pro Arg Ala Trp Lys Thr Phe Ile Asp Thr Val Arg 
                 805                810                815
Cys Thr Thr Ala Ala His Leu Ala Leu Leu Val Pro Lys Asn Ile Ala 
             820                825                830
Phe Tyr Pro Ser Asn His Glu Arg Tyr Leu Glu Gly His Ile Asp Val 
         835                840                845
Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu 
     850                855                860
Leu Arg Gln His Lys Val Trp Lys Lys Cys Arg Met Arg Ile Phe Thr 
 865                870                875                880
Val Ala Gln Met Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Ala 
                 885                890                895
Ile Phe Leu Tyr His Leu Arg Leu Glu Ala Glu Val Glu Val Val Glu 
             900                905                910
Met His Asn Ser Asp Ile Ser Ala Tyr Thr Tyr Glu Arg Thr Leu Met 
         915                920                925
Met Glu Gln Arg Ser Gln Met Leu Arg Gln Met Arg Leu Thr Lys Thr 
     930                935                940
Glu Arg Asp Arg Glu Ala Gln Leu Val Lys Asp Arg His Ser Ala Leu 
 945                950                955                960
Arg Leu Glu Ser Leu Tyr Ser Asp Glu Glu Asp Glu Ser Val Thr Gly 
                 965                970                975
Ala Asp Lys Ile Gln Met Thr Trp Thr Arg Asp Lys Tyr Met Ala Glu 
             980                985                990
Pro Trp Asp Pro Ser His Ala Pro Asp Asn Phe Arg Glu Leu Val His 
         995                1000                1005
Ile Lys Pro Asp Gln Ser Asn Val Arg Arg Met His Thr Ala Val Lys 
     1010                1015                1020
Leu Asn Glu Val Ile Val Thr Arg Ser His Asp Ala Arg Leu Val Leu 
 1025                1030                1035                1040
Leu Asn Met Pro Gly Pro Pro Lys Asn Ser Glu Gly Asp Glu Asn Tyr 
                 1045                1050                1055
Met Glu Phe Leu Glu Val Leu Thr Glu Gly Leu Glu Arg Val Leu Leu 
             1060                1065                1070
Val Arg Gly Gly Gly Arg Glu Val Ile Thr Ile Tyr Ser 
         1075                1080                1085



<210> 8694
<211> 4318
<212> DNA
<213> Homo sapiens
<308> AK024493
<400> 8694

gacatcccg  tctgcctcc  ggggaaccg  acgctgtca  ggcgcagct  cgatgcctg  60
gtcaaggcc  acggcatcc  caacaactc  gccacctcc  cgctctggg  cctcttctg  120
aacggctcc  agcccagcg  cgcctgtga  gagtacttc  tccagaaca  cgtcaccga  180
atccagggc  tcccgggcg  ggccagtgg  gtcttcctg  agaacctgt  gagtacgta  240
gcgcacgcg  gggcgtttg  ggagaagaa  ggtgtgccc  cggtgcccg  ggcagagga  300
agccgtgcc  gcgcactgc  ctacgtgct  accgacatc  cggcctcct  caccctgct  360
gttggcatc  acttcccct  cgtgaccgg  atcatggcg  gttcaaacc  gtccgggga  420
ctcaaggat  cacagaagt  catccccac  gggaccatc  tggccatag  gacgacgtc  480
ttcatctat  tctcctgca  tgtgctgtt  ggggcctgc  ttgaaggcg  ggtcttacg  540
gataagttc  gggaggccc  gcaggggaa  ctggtcatc  gcatgctgg  ctggccctc  600
ccctgggtc  tcgtcatcg  ctccttctt  tccacctgc  gtgccggcc  gcagagcct  660
acgggggca  cgcgcctac  gcaggccat  gcccgtgac  gcatcgtcc  cttcctgca  720
gtgtttggc  acgggaagg  caacgggga  cccacgtgg  cgctgctgc  gacagtcct  780
atctgcgag  ctggcatcc  catcgcctc  ctggacagc  tggccccga  cctctccat  840
ttcttcctc  tgtgctacc  gttcgtgaa  ctggcctgc  ccgtgcaga  cctgctacg  900
acccccaac  ggcgtccac  cttcaagtt  taccactgg  ccctgtcct  tctgggtat  960
agcctgtgc  tggcgctga  gttcatctg  tcctggtac  acgcgctgt  cgccatgct  1020
atcgctggc  gcatctaca  gtacatcga  taccgcggg  ccgagaagg  gtggggcga  1080
ggcatccgt  gcctatccc  gaacgccgc  cgctacgcc  tgctgcgcg  ggagcacgg  1140
cccccccac  ccaagaact  gaggcccca  gtgctggtg  tgctgaacc  ggacgcgga  1200
caggccgtg  agcaccccc  cctgctgtc  ttcacgtcg  agctgaagg  cggcaaggg  1260
ctgaccatc  tgggctcgg  gctggaggg  acgtacctg  acaagcaca  ggaggctca  1320
cgggccgag  agaacatac  gtccctaat  agcacagag  agaccaagg  cttctgcca  1380
ctggtggtc  cgtccagcc  gcgggatgg  atgtcccac  tgatccagt  ggccggcct  1440
ggcggcctg  agcacaaca  ggtgctcat  gcctggccc  catcctgga  gcaggagga  1500
aaccccttc  cctggaaga  ctttgtaga  accgtccgc  acaccaccg  cgcgcacca  1560
gctctgctg  tggccaaga  cgtcgactc  tttccgcaa  accaggagc  cttcggcgg  1620
ggccacatc  acgtgtggt  gatcgtgca  gacggcggc  tgctcatgc  gctgccctt  1680
ctgctgcgc  agcacaagg  gtggaggaa  tgccggatg  gtatcttca  cgtggccca  1740
gtggacgac  acagcatcc  gatgaagaa  gacctgcag  tgttcttgt  ccacttgcg  1800
atcagcgcc  aggtggagg  ggtggagat  gttgaaaac  acatatctg  tttcaccta  1860
gagaggaca  taatgatgg  gcagaggtc  cagatgctg  agcagatgc  gctgtccaa  1920
aacgagcag  agcgagagg  ccagctgat  cacgacagg  acaccgcgt  ccacaccgc  1980
gcggcagcc  ggacccaag  gccgcctac  ccagacaag  tgcagatga  ctggaccag  2040
gagaagctg  tcgctgaga  gtacaggag  agagacacc  gcctatctg  tttcaaaga  2100
ctcttcagc  tgaagccgg  ccagtccaa  gtcaggcgg  tgcacacgg  tgtgaagct  2160
aatggcgtc  tcctcaaca  gtcccagga  gcgcagctg  tcctgctca  catgccagg  2220
cctcccaaa  accggcagg  agacgagaa  tacatggag  ttcttgaag  cctgaccga  2280
gggctgaac  gagtcctcc  ggtcagggg  ggcggccgg  aggtgatca  catctactc  2340
taatgccca  cagcatcac  gcactctgg  acaggcacg  aggacggcg  gggcagcct  2400
ggcctgggc  tggcccagg  aaacagacg  cagacacac  tgtccccca  tgatgccac  2460
caagctgcc  atggggctt  ctacggaag  ttctaggcc  gtcacctag  gctctcctg  2520
tcagcctta  caggctcag  aaatcaggg  gtggctgga  gatttcctt  catctgagg  2580
cagacgctg  taccggagt  acctggacg  ggccagatc  tctcgcagg  cacaagaag  2640
cagtgagcc  ttgccttgg  ttctggaag  tcttttcct  ggctggatt  acccagtgg  2700
taggttgca  ttctacccc  tccagaaca  tcttggaag  gcacccgga  ctgaagctg  2760
ccctgatga  gaaggtgaa  cgtcagccc  ggccatggc  ccgctcagg  ccccggtca  2820
ctccgagtc  ctctgttcc  tgactgtct  tgtgtttct  tacctcaag  cactgaagc  2880
ggaggactc  gtccatgcc  gtgtcaccc  cgtgtggga  cctctgggc  cggcaggtc  2940
acatttcat  agctgaggc  tgggccagg  ccatctgga  agggaactc  gcttttcca  3000
aacgtggtg  atcatctgt  gggtgtgtg  tgaacacgt  cagttcatc  gggcctacg  3060
tccgggaag  ggcccccag  tgtggctct  ccatgccgg  ctgtgtttg  agctgtccg  3120
gtctccatc  acctttaga  aaccagcca  ttcttttca  aagcactga  agggcccag  3180
ccacagcca  aggtgcgat  agtgcctca  gcaggcaaa  gcactgaaa  ccaggggca  3240
acgcgcgca  agtgaacag  gagttcccc  gacagccca  gacagccag  actgccctc  3300
ccaccccac  ccaccccag  agcacggca  acagttcag  ctctgagct  gctcacacg  3360
gccatcccc  ccccggtgc  ccagggaag  aggacacgg  cccgacgtg  gaggtcctc  3420
ggcagcagt  gcgcctggt  tcaggtctg  ctggctgag  cccgggcgt  ccctgccat  3480
gcctgtgcc  tgcatggag  cggcggtgg  actgaagag  tagctttca  gggcccaac  3540
ctttgcact  cggctggct  tgagtttct  ctttgtagg  tgtggtcac  tttgcaggc  3600
gcgggcagt  gcaccgact  gggcctccc  ttctatgtg  catatttat  tatttaaac  3660
ccccaggga  ttacgtggt  acaaggttg  ccataaaga  gttgcttct  tatactaga  3720
gccccagat  gccaggcct  gggctacgt  tggcttgca  ggtctccca  gggaatcag  3780
cccatcaac  aagttcaaa  cggggcaga  gctgcactt  tgcccccag  tgtttctga  3840
gagccagac  agggctggc  ttgctgtag  gtgacggct  ctgcccaga  cgtgtccca  3900
acatcacag  ggggctcag  agttcccac  gcctctgcc  gccttggct  agcatgagt  3960
aagcagcaa  acgctcctc  atgtctgga  ggggccggc  ggtcctgtg  cccctgcac  4020
tggaggaga  caggctaga  gcacagcgg  cacatggtg  tggctctga  cgttggttg  4080
tggctggaa  acagccctg  ttctgaggg  cgctcagtt  tgcacacga  accacctcc  4140
gagggctca  ctctgcccc  gccctgggc  gcagcctct  cacgcaagc  ccaggcatc  4200
tttgtgttg  caactccgt  taaccagta  ctacagcca  ttacaattg  ctccgtttc  4260
ttttgtagg  ttccctgtc  gtctgtgtt  gtagaaaaa  aaaatccta  gaaatctg  4318



<210> 8695
<211> 1085
<212> PRT
<213> Homo sapiens
<308> NP_005063
<400> 8695

Met Pro His Phe Thr Val Val Pro Val Asp Gly Pro Arg Arg Gly Asp 
  1               5                  10                  15
Tyr Asp Asn Leu Glu Gly Leu Ser Trp Val Asp Tyr Gly Glu Arg Ala 
             20                  25                  30
Glu Leu Asp Asp Ser Asp Gly His Gly Asn His Arg Glu Ser Ser Pro 
         35                  40                  45
Phe Leu Ser Pro Leu Glu Ala Ser Arg Gly Ile Asp Tyr Tyr Asp Arg 
     50                  55                  60
Asn Leu Ala Leu Phe Glu Glu Glu Leu Asp Ile Arg Pro Lys Val Ser 
 65                  70                  75                  80
Ser Leu Leu Gly Lys Leu Val Ser Tyr Thr Asn Leu Thr Gln Gly Ala 
                 85                  90                  95
Lys Glu His Glu Glu Ala Glu Ser Gly Glu Gly Thr Arg Arg Arg Ala 
             100                105                110
Ala Glu Ala Pro Ser Met Gly Thr Leu Met Gly Val Tyr Leu Pro Cys 
         115                120                125
Leu Gln Asn Ile Phe Gly Val Ile Leu Phe Leu Arg Leu Thr Trp Met 
     130                135                140
Val Gly Thr Ala Gly Val Leu Gln Ala Leu Leu Ile Val Leu Ile Cys 
 145                150                155                160
Cys Cys Cys Thr Leu Leu Thr Ala Ile Ser Met Ser Ala Ile Ala Thr 
                 165                170                175
Asn Gly Val Val Pro Ala Gly Gly Ser Tyr Phe Met Ile Ser Arg Ser 
             180                185                190
Leu Gly Pro Glu Phe Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly 
         195                200                205
Thr Thr Phe Ala Ala Ala Met Tyr Ile Leu Gly Ala Ile Glu Ile Leu 
     210                215                220
Leu Thr Tyr Ile Ala Pro Pro Ala Ala Ile Phe Tyr Pro Ser Gly Ala 
 225                230                235                240
His Asp Thr Ser Asn Ala Thr Leu Asn Asn Met Arg Val Tyr Gly Thr 
                 245                250                255
Ile Phe Leu Thr Phe Met Thr Leu Val Val Phe Val Gly Val Lys Tyr 
             260                265                270
Val Asn Lys Phe Ala Ser Leu Phe Leu Ala Cys Val Ile Ile Ser Ile 
         275                280                285
Leu Ser Ile Tyr Ala Gly Gly Ile Lys Ser Ile Phe Asp Pro Pro Val 
     290                295                300
Phe Pro Val Cys Met Leu Gly Asn Arg Thr Leu Ser Arg Asp Gln Phe 
 305                310                315                320
Asp Ile Cys Ala Lys Thr Ala Val Val Asp Asn Glu Thr Val Ala Thr 
                 325                330                335
Gln Leu Trp Ser Phe Phe Cys His Ser Pro Asn Leu Thr Thr Asp Ser 
             340                345                350
Cys Asp Pro Tyr Phe Met Leu Asn Asn Val Thr Glu Ile Pro Gly Ile 
         355                360                365
Pro Gly Ala Ala Ala Gly Val Leu Gln Glu Asn Leu Trp Ser Ala Tyr 
     370                375                380
Leu Glu Lys Gly Asp Ile Val Glu Lys His Gly Leu Pro Ser Ala Asp 
 385                390                395                400
Ala Pro Ser Leu Lys Glu Ser Leu Pro Leu Tyr Val Val Ala Asp Ile 
                 405                410                415
Ala Thr Ser Phe Thr Val Leu Val Gly Ile Phe Phe Pro Ser Val Thr 
             420                425                430
Gly Ile Met Ala Gly Ser Asn Arg Ser Gly Asp Leu Arg Asp Ala Gln 
         435                440                445
Lys Ser Ile Pro Val Gly Thr Ile Leu Ala Ile Ile Thr Thr Ser Leu 
     450                455                460
Val Tyr Phe Ser Ser Val Val Leu Phe Gly Ala Cys Ile Glu Gly Val 
 465                470                475                480
Val Leu Arg Asp Lys Tyr Gly Asp Gly Val Ser Arg Asn Leu Val Val 
                 485                490                495
Gly Thr Leu Ala Trp Pro Ser Pro Trp Val Ile Val Ile Gly Ser Phe 
             500                505                510
Phe Ser Thr Cys Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg 
         515                520                525
Leu Leu Gln Ala Ile Ala Lys Asp Asn Ile Ile Pro Phe Leu Arg Val 
     530                535                540
Phe Gly His Gly Lys Val Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu 
 545                550                555                560
Thr Ala Leu Ile Ala Glu Leu Gly Ile Leu Ile Ala Ser Leu Asp Met 
                 565                570                575
Val Ala Pro Ile Leu Ser Met Phe Phe Leu Met Cys Tyr Leu Phe Val 
             580                585                590
Asn Leu Ala Cys Ala Val Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg 
         595                600                605
Pro Arg Phe Lys Tyr Tyr His Trp Ala Leu Ser Phe Leu Gly Met Ser 
     610                615                620
Leu Cys Leu Ala Leu Met Phe Val Ser Ser Trp Tyr Tyr Ala Leu Val 
 625                630                635                640
Ala Met Leu Ile Ala Gly Met Ile Tyr Lys Tyr Ile Glu Tyr Gln Gly 
                 645                650                655
Ala Glu Lys Glu Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Ser Ala 
             660                665                670
Ala Arg Tyr Ala Leu Leu Arg Leu Glu Glu Gly Pro Pro His Thr Lys 
         675                680                685
Asn Trp Arg Pro Gln Leu Leu Val Leu Leu Lys Leu Asp Glu Asp Leu 
     690                695                700
His Val Lys Tyr Pro Arg Leu Leu Thr Phe Ala Ser Gln Leu Lys Ala 
 705                710                715                720
Gly Lys Gly Leu Thr Ile Val Gly Ser Val Ile Gln Gly Ser Phe Leu 
                 725                730                735
Glu Ser Tyr Gly Glu Ala Gln Ala Ala Glu Gln Thr Ile Lys Asn Met 
             740                745                750
Met Glu Ile Glu Lys Val Lys Gly Phe Cys Gln Val Val Val Ala Ser 
         755                760                765
Lys Val Arg Glu Gly Leu Ala His Leu Ile Gln Ser Cys Gly Leu Gly 
     770                775                780
Gly Met Arg His Asn Ser Val Val Leu Gly Trp Pro Tyr Gly Trp Arg 
 785                790                795                800
Gln Ser Glu Asp Pro Arg Ala Trp Lys Thr Phe Ile Asp Thr Val Arg 
                 805                810                815
Cys Thr Thr Ala Ala His Leu Ala Leu Leu Val Pro Lys Asn Ile Ala 
             820                825                830
Phe Tyr Pro Ser Asn His Glu Arg Tyr Leu Glu Gly His Ile Asp Val 
         835                840                845
Trp Trp Ile Val His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu 
     850                855                860
Leu Arg Gln His Lys Val Trp Arg Lys Cys Arg Met Arg Ile Phe Thr 
 865                870                875                880
Val Ala Gln Met Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Ala 
                 885                890                895
Val Phe Leu Tyr His Leu Arg Leu Glu Ala Glu Val Glu Val Val Glu 
             900                905                910
Met His Asn Ser Asp Ile Ser Ala Tyr Thr Tyr Glu Arg Thr Leu Met 
         915                920                925
Met Glu Gln Arg Ser Gln Met Leu Arg Gln Met Arg Leu Thr Lys Thr 
     930                935                940
Glu Arg Glu Arg Glu Ala Gln Leu Val Lys Asp Arg His Ser Ala Leu 
 945                950                955                960
Arg Leu Glu Ser Leu Tyr Ser Asp Glu Glu Asp Glu Ser Ala Val Gly 
                 965                970                975
Ala Asp Lys Ile Gln Met Thr Trp Thr Arg Asp Lys Tyr Met Thr Glu 
             980                985                990
Thr Trp Asp Pro Ser His Ala Pro Asp Asn Phe Arg Glu Leu Val His 
         995                1000                1005
Ile Lys Pro Asp Gln Ser Asn Val Arg Arg Met His Thr Ala Val Lys 
     1010                1015                1020
Leu Asn Glu Val Ile Val Thr Arg Ser His Asp Ala Arg Leu Val Leu 
 1025                1030                1035                1040
Leu Asn Met Pro Gly Pro Pro Arg Asn Ser Glu Gly Asp Glu Asn Tyr 
                 1045                1050                1055
Met Glu Phe Leu Glu Val Leu Thr Glu Gly Leu Glu Arg Val Leu Leu 
             1060                1065                1070
Val Arg Gly Gly Gly Arg Glu Val Ile Thr Ile Tyr Ser 
         1075                1080                1085



<210> 8696
<211> 1688
<212> DNA
<213> Rattus norvegicus
<308> U56839
<400> 8696

gaattcctg  ctcagtccc  gtagctggt  caggcctgt  cacatgcga  tgaagaact  60
gaacggacg  tgagcatcc  agagcacct  ctgcagcac  tgctgtcac  ccaagagca  120
gagctgatc  ggtccaggg  aatggcagc  ggcctggac  cctggaata  taccatcaa  180
ggcacctgg  agggggacg  actgggtta  aaatgtcgc  tcaacgagg  cttcaagta  240
gtgctgctg  ccgtgtcct  tggcgtggt  tgcgtgctc  ggctgtgcc  gaacgtcgt  300
gccctctac  tcttcctgt  ccgcctcaa  acctggaac  cctccacca  ctacatgtt  360
cacctggca  tttctgact  tctctacgc  gcctccctg  cgctgctgg  ttattacta  420
gcccagggt  accactggc  atttagcac  gtgctctgc  agctggtgc  tttcctttt  480
tacactaac  tctactgca  catcctctt  ctcacctgc  tcagcgtgc  ccggtgcct  540
ggggtcctg  gccctctgc  ctccctgag  tggggccat  cccgctatg  ccgccgagt  600
gctgcggtt  tgtgggtgc  agtgctggc  tgccaggca  ccgtgctct  ctttgtcac  660
accagcgtg  gagggaccc  aatcacctg  cacgacacc  cggcccgag  gctctttag  720
cattttgtg  cttacagct  tgtcatgct  ggtctgctt  ttgctgtgc  cttttccat  780
atcctggtc  gttacgtgc  catggcccg  cggctgctc  aaccggctt  tgggaccac  840
ggtctgcct  gggccaagc  caagtctgt  cgcaccatc  ccttagtac  ggccgtctt  900
gccctctgc  tcctgcctt  ccacgtcac  cgcaccctc  attactcct  ccgatcact  960
gacctcagt  gccacaccc  caacgccat  aacatggcg  ataagatca  ccggccact  1020
gccagcgcc  acagttgcc  tgaccctgt  ctctacttc  tggcagggc  gagactggt  1080
cgctttgcc  gagatgcca  gcccgccac  gagcctaca  ccagcccac  ggctcgtcg  1140
aagctgggg  tgcacaggc  taacagaac  gacactgtg  ggaaagatt  gtcgatcag  1200
agtgatgac  caagaagga  agagtccac  ccagctgga  gtgagacta  ggacattcg  1260
ctatagcag  tcagtcagg  gtcagttca  gtaggggag  gctgtaggg  accaaagct  1320
gttcaaagg  gctgatatc  tctgatatg  tatcaacgg  tctcatttg  cagggactc  1380
ggatactca  cctgtggtc  caagagtga  aggacccca  agtccccaa  catttgtat  1440
tgtgagttg  ggaatcgta  ctaaggcaa  gccacctga  tcccatgca  acagctgcc  1500
ttcctgcca  ggtacctag  ccgagcttc  gcctcttaa  tccaaggga  aagcaggcc  1560
agggagaac  cagcagagt  cagactagc  acctggatt  gaagtagaa  cgaggggtt  1620
gggatttag  tcagcggta  agcgccctg  gttcagtcc  cagctccgg  aaaaaaaag  1680
aaaaaaaa  1688



<210> 8697
<211> 374
<212> PRT
<213> Rattus norvegicus
<308> P41232
<400> 8697

Met Ala Ala Gly Leu Asp Ser Trp Asn Ser Thr Ile Asn Gly Thr Trp 
  1               5                  10                  15
Glu Gly Asp Glu Leu Gly Tyr Lys Cys Arg Phe Asn Glu Asp Phe Lys 
             20                  25                  30
Tyr Val Leu Leu Pro Val Ser Tyr Gly Val Val Cys Val Leu Gly Leu 
         35                  40                  45
Cys Leu Asn Val Val Ala Leu Tyr Ile Phe Leu Cys Arg Leu Lys Thr 
     50                  55                  60
Trp Asn Ala Ser Thr Thr Tyr Met Phe His Leu Ala Val Ser Asp Ser 
 65                  70                  75                  80
Leu Tyr Ala Ala Ser Leu Pro Leu Leu Val Tyr Tyr Tyr Ala Gln Gly 
                 85                  90                  95
Asp His Trp Pro Phe Ser Thr Val Leu Cys Lys Leu Val Arg Phe Leu 
             100                105                110
Phe Tyr Thr Asn Leu Tyr Cys Ser Ile Leu Phe Leu Thr Cys Ile Ser 
         115                120                125
Val His Arg Cys Leu Gly Val Leu Arg Pro Leu His Ser Leu Ser Trp 
     130                135                140
Gly His Ala Arg Tyr Ala Arg Arg Val Ala Ala Val Val Trp Val Leu 
 145                150                155                160
Val Leu Ala Cys Gln Ala Pro Val Leu Tyr Phe Val Thr Thr Ser Val 
                 165                170                175
Arg Gly Thr Arg Ile Thr Cys His Asp Thr Ser Ala Arg Glu Leu Phe 
             180                185                190
Ser His Phe Val Ala Tyr Ser Ser Val Met Leu Gly Leu Leu Phe Ala 
         195                200                205
Val Pro Phe Ser Ile Ile Leu Val Cys Tyr Val Leu Met Ala Arg Arg 
     210                215                220
Leu Leu Lys Pro Ala Tyr Gly Thr Thr Gly Leu Pro Arg Ala Lys Arg 
 225                230                235                240
Lys Ser Val Arg Thr Ile Ala Leu Val Leu Ala Val Phe Ala Leu Cys 
                 245                250                255
Phe Leu Pro Phe His Val Thr Arg Thr Leu Tyr Tyr Ser Phe Arg Ser 
             260                265                270
Leu Asp Leu Ser Cys His Thr Leu Asn Ala Ile Asn Met Ala Tyr Lys 
         275                280                285
Ile Thr Arg Pro Leu Ala Ser Ala Asn Ser Cys Leu Asp Pro Val Leu 
     290                295                300
Tyr Phe Leu Ala Gly Gln Arg Leu Val Arg Phe Ala Arg Asp Ala Lys 
 305                310                315                320
Pro Ala Thr Glu Pro Thr Pro Ser Pro Gln Ala Arg Arg Lys Leu Gly 
                 325                330                335
Leu His Arg Pro Asn Arg Thr Asp Thr Val Arg Lys Asp Leu Ser Ile 
             340                345                350
Ser Ser Asp Asp Ser Arg Arg Thr Glu Ser Thr Pro Ala Gly Ser Glu 
         355                360                365
Thr Lys Asp Ile Arg Leu 
     370



<210> 8698
<211> 2681
<212> DNA
<213> Homo sapiens
<308> BC012104
<400> 8698

gaacagcgc  gggaggtgg  tagccgggc  cccaggcac  tgggtctct  cggctgcgg  60
gggacccgg  cactggcac  cgggagcgg  ggcgacggc  ccccgagag  agaagcgca  120
cgcagtggc  agaggagcc  cttgtggca  cagcactac  tgcccagaa  aatgctgga  180
gctgggcgt  gccccaggc  tggggacct  tttttcctg  ttcccgcag  gttccctgc  240
gcccggtcc  ggtccaggc  tgtgcattc  tgagtgagg  acccgtgca  gcgctgagc  300
tcctgacct  tagagcagg  gctggtcag  ttccagagc  tggaggttc  aggtccaga  360
ccaagtcag  tggcaatga  agccctggt  aggtggctg  gtcaggtcc  ctaggggcg  420
tccggccac  accctgatg  ccccacccc  cccttccct  cagggcgat  gcagcagac  480
tgggcccct  gaatgacac  atcaatggc  cctgggatg  ggatgagct  ggctacagg  540
gccgcttca  cgaggactt  aagtacgtg  tgctgcctg  gtcctacgg  gtggtgtgc  600
tgcttgggc  gtgtctgaa  gccgtggcg  tctacatct  cttgtgccg  ctcaagacc  660
ggaatgcgt  caccacata  atgttccac  tggctgtgt  tgatgcact  tatgcggcc  720
ccctgccgc  gctggtcta  tactacgcc  gcggcgacc  ctggccctt  agcacggtg  780
tctgcaagc  ggtgcgctt  ctcttctac  ccaaccttt  ctgcagcat  ctcttcctc  840
cctgcatca  cgtgcaccg  tgtctgggc  tcttacgac  tctgcgctc  ctgcgctgg  900
gccgggccc  ctacgctcg  cgggtggcc  gggccgtgt  ggtgttggt  ctggcctgc  960
aggcccccg  gctctactt  gtcaccacc  gcgcgcgcg  gggccgcgt  acctgccac  1020
acacctcgg  acccgagct  ttcagccgc  tcgtggcct  cagctcagt  atgctgggc  1080
tgctcttcg  ggtgccctt  gccgtcatc  ttgtctgtt  cgtgctcat  gctcggcga  1140
tgctaaagc  agcctacgg  acctcgggc  gcctgccta  ggccaagcg  aagtccgtg  1200
gcaccatcg  cgtggtgct  gctgtcttc  ccctctgct  cctgccatt  cacgtcacc  1260
gcaccctct  ctactcctt  cgttcgctg  acctcagct  ccacaccct  aacgccatc  1320
acatggcct  caaggttac  cggccgctg  ccagtgcta  cagttgcct  gaccccgtg  1380
tctacttcc  ggctgggca  agcctcgta  gctttgccc  agatgccaa  ccacccact  1440
gccccagcc  tgccacccc  gctcgccgc  ggctgggcc  gcgcagatc  gacagaact  1500
acatgcaga  gatagaaga  gtgttgggc  gcagtgagg  ctctaggcg  acagagtcc  1560
cgccggctg  tagcgagaa  actaaggac  ttcggctgt  ggagcagaa  acttcagcc  1620
gtgcaggtt  atattggga  gctgtagag  accaggact  gtgcagacg  cacagtctc  1680
ccagatatg  accatcagt  actcatgct  gatgacccc  tgctccgtc  tttgacagg  1740
gctcaggat  ttcactctg  ggtccagag  caactgttc  cataacccc  agtcatcgt  1800
tgtgtgtat  agttggggg  attaagttt  aagaaaggc  agagctcaa  gtcaatgac  1860
cccctggcc  gactcccat  caagtagct  gctgtactg  caaggtacc  aggttggag  1920
ccagcctaa  caagtcaaa  ggagaaaca  gcccagaga  gaaggtggc  taccaagat  1980
acataccag  gtctggagc  gagctacct  gggtggggg  caagtcaca  gttggccag  2040
aaaccctgg  aagtaatga  ggctgagtt  gcacagtgg  ctggaatgg  ctgggtgcc  2100
cggtggact  agctctgag  agtaccccc  gcccaagag  tgaacatct  gggactaat  2160
tcatagacc  atctggagg  tcccatggg  taggagcca  tgtgaggct  taacttata  2220
taaaggttg  gttgcctgc  gagctgtgc  ctattgtgt  gtcggggga  gaggatatg  2280
cagggaagc  ttcaccagc  acacaaggg  cctttctcc  atccgttcc  ttttgccac  2340
tgccttctc  ctagctgtc  caggagtag  ctcatatca  ggatcctct  tccaggccc  2400
aggtcatcc  ccactgtaa  gccagttgg  ttctgtgcc  gactctgtg  tgagcacag  2460
gaaaagtca  gtgcagtcc  agtccttga  atttcccag  ttaggtgat  gccagtcat  2520
tgctggtaa  tgttaagcc  tttaactgg  gctccgatt  aactgggaa  cccttcttt  2580
tagaactgc  catttccat  gtgcaaaaa  tcttatggc  aaattcaaa  tataaacat  2640
atgtcaact  ccttgtaaa  aaaaaaaaa  aaaaaaaaa  a  2681



<210> 8699
<211> 377
<212> PRT
<213> Homo sapiens
<308> P41231
<400> 8699

Met Ala Ala Asp Leu Gly Pro Trp Asn Asp Thr Ile Asn Gly Thr Trp 
  1               5                  10                  15
Asp Gly Asp Glu Leu Gly Tyr Arg Cys Arg Phe Asn Glu Asp Phe Lys 
             20                  25                  30
Tyr Val Leu Leu Pro Val Ser Tyr Gly Val Val Cys Val Leu Gly Leu 
         35                  40                  45
Cys Leu Asn Ala Val Ala Leu Tyr Ile Phe Leu Cys Arg Leu Lys Thr 
     50                  55                  60
Trp Asn Ala Ser Thr Thr Tyr Met Phe His Leu Ala Val Ser Asp Ala 
 65                  70                  75                  80
Leu Tyr Ala Ala Ser Leu Pro Leu Leu Val Tyr Tyr Tyr Ala Arg Gly 
                 85                  90                  95
Asp His Trp Pro Phe Ser Thr Val Leu Cys Lys Leu Val Arg Phe Leu 
             100                105                110
Phe Tyr Thr Asn Leu Tyr Cys Ser Ile Leu Phe Leu Thr Cys Ile Ser 
         115                120                125
Val His Arg Cys Leu Gly Val Leu Arg Pro Leu Arg Ser Leu Arg Trp 
     130                135                140
Gly Arg Ala Arg Tyr Ala Arg Arg Val Ala Gly Ala Val Trp Val Leu 
 145                150                155                160
Val Leu Ala Cys Gln Ala Pro Val Leu Tyr Phe Val Thr Thr Ser Ala 
                 165                170                175
Arg Gly Gly Arg Val Thr Cys His Asp Thr Ser Ala Pro Glu Leu Phe 
             180                185                190
Ser Arg Phe Val Ala Tyr Ser Ser Val Met Leu Gly Leu Leu Phe Ala 
         195                200                205
Val Pro Phe Ala Val Ile Leu Val Cys Tyr Val Leu Met Ala Arg Arg 
     210                215                220
Leu Leu Lys Pro Ala Tyr Gly Thr Ser Gly Gly Leu Pro Arg Ala Lys 
 225                230                235                240
Arg Lys Ser Val Arg Thr Ile Ala Val Val Leu Ala Val Phe Ala Leu 
                 245                250                255
Cys Phe Leu Pro Phe His Val Thr Arg Thr Leu Tyr Tyr Ser Phe Arg 
             260                265                270
Ser Leu Asp Leu Ser Cys His Thr Leu Asn Ala Ile Asn Met Ala Tyr 
         275                280                285
Lys Val Thr Arg Pro Leu Ala Ser Ala Asn Ser Cys Leu Asp Pro Val 
     290                295                300
Leu Tyr Phe Leu Ala Gly Gln Arg Leu Val Arg Phe Ala Arg Asp Ala 
 305                310                315                320
Lys Pro Pro Thr Gly Pro Ser Pro Ala Thr Pro Ala Arg Arg Arg Leu 
                 325                330                335
Gly Leu Arg Arg Ser Asp Arg Thr Asp Met Gln Arg Ile Glu Asp Val 
             340                345                350
Leu Gly Ser Ser Glu Asp Ser Arg Arg Thr Glu Ser Thr Pro Ala Gly 
         355                360                365
Ser Glu Asn Thr Lys Asp Ile Arg Leu 
     370                375



<210> 8700
<211> 1578
<212> DNA
<213> Rattus norvegicus
<308> U56862
<400> 8700

cgaaaacct  gaaacaaag  atttcctgt  ggcacagac  ttggttctg  aagagtccc  60
cctatatat  ggctccaga  gaaaagaaa  tgaactgtg  tttccccac  ttcctcatt  120
ctgaacatg  gagaactgt  aggaagaac  attaacaca  agacagttc  gtctttcag  180
cccttgtaa  cacatctcc  gtcactcac  taaaaatct  tcatatatc  ggcttgact  240
gacacttac  aattaatat  gaaaagaaa  tgtacgtat  cagtgaatg  ggcaaagcg  300
tcatccaac  tcagtagat  ctaggcgag  atccttgtg  gaaacagaa  gttggaaag  360
cttcagccc  agtcagagc  tctgcatga  gaacctgat  ctggagaga  agtttatga  420
tgtgatgaa  gtaggaaaa  ctttagcct  gaacaacac  ttgtggaac  taagaaaac  480
cacggtggg  agaagtcac  cgagtgtac  ggatgtggt  aagagttct  gaaagcctc  540
tcacttact  gacatctga  aagtcgctc  cggagggaa  catataagt  tggtaactg  600
gggagaacc  tcagccaga  aggaaactt  ctttctcac  agaaacaac  tgctgaaga  660
agacccagt  agtctaaga  aactcccgt  cccatgaca  ccatcgtca  aaatcagag  720
aacgccggg  ataaaccat  tgcgtgtaa  gagtgtggg  aagccttta  tggcaaatc  780
tatctcaaa  aacatgaga  aattcatac  ggagagaaa  catttgaat  taatcagtg  840
ggtagagcc  tcagccaga  gcagtacct  attaaacac  agaacgtcc  cagtgggaa  900
aagcctttt  agtgtaatg  gtgtggtaa  gcttttagc  agaaagaaa  cctcattat  960
caccagaga  tccataccg  agagaagcc  tatgaatgt  aagggtgtg  gaaggcctt  1020
attcagaaa  caagcctca  cagacacca  aggagccat  ctggagaga  accgtacac  1080
tgtaaggaa  gtgggaaag  cttcagcgg  aaatcaaac  tgactgagc  tgagaaaat  1140
catattgga  agaaaccct  taaatgtaa  gagtgtgga  caattttca  gcagaagca  1200
tacctcatc  aacatcaca  cattcacac  ggcgagaag  catatgagt  caataagtg  1260
ggaaaggcc  tttctcgaa  cacgtcgct  attgtgcat  tgagaattc  cacaggcga  1320
aagccctat  agtgtaaag  ctgtgggaa  gccttctgt  agagttcgt  tctaaccgt  1380
catatgagg  gccacacgg  tgagaaacc  tatggctgc  atgagtgtg  gaaggcttt  1440
tctcagttc  ccactcttg  tttacacat  agaatccac  ctggcgaga  gccttatca  1500
tgcagtgag  gtgggaagg  cttcagcca  aagtcccat  acatcagac  ccagagaat  1560
catattcac  aaaactct  1578



<210> 8701
<211> 407
<212> PRT
<213> Rattus norvegicus
<308> Q62981
<400> 8701

Met Leu Glu Ser Leu Gln Pro Glu Ser Glu Leu Leu His Asp Glu Pro 
  1               5                  10                  15
Asp Pro Gly Glu Lys Val Tyr Glu Cys Asp Glu Cys Arg Lys Thr Phe 
             20                  25                  30
Ser Leu Glu Gln His Phe Val Glu His Lys Lys Thr His Gly Gly Glu 
         35                  40                  45
Lys Ser Pro Glu Cys Thr Gly Cys Gly Glu Glu Phe Ser Lys Ala Ser 
     50                  55                  60
Ser Leu Thr Arg His Leu Arg Ser Arg Ser Arg Arg Glu Ser Tyr Lys 
 65                  70                  75                  80
Cys Gly Asn Cys Gly Arg Thr Phe Ser Gln Arg Gly Asn Phe Leu Ser 
                 85                  90                  95
His Gln Lys Gln His Ala Glu Glu Arg Pro Ser Glu Ser Lys Lys Thr 
             100                105                110
Pro Val Pro Met Thr Thr Ile Val Arg Asn Gln Arg Asn Ala Gly Asn 
         115                120                125
Lys Pro Tyr Ala Cys Lys Glu Cys Gly Lys Ala Phe Asn Gly Lys Ser 
     130                135                140
Tyr Leu Lys Glu His Glu Lys Ile His Thr Gly Glu Lys Pro Phe Glu 
 145                150                155                160
Cys Asn Gln Cys Gly Arg Ala Phe Ser Gln Lys Gln Tyr Leu Ile Lys 
                 165                170                175
His Gln Asn Val His Ser Gly Lys Lys Pro Phe Lys Cys Asn Glu Cys 
             180                185                190
Gly Lys Ala Phe Ser Gln Lys Glu Asn Leu Ile Ile His Gln Arg Ile 
         195                200                205
His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gly Cys Gly Lys Ala Phe 
     210                215                220
Ile Gln Lys Ser Ser Leu Ile Arg His Gln Arg Ser His Thr Gly Glu 
 225                230                235                240
Lys Pro Tyr Thr Cys Lys Glu Cys Gly Lys Ala Phe Ser Gly Lys Ser 
                 245                250                255
Asn Leu Thr Glu His Glu Lys Ile His Ile Gly Glu Lys Pro Tyr Lys 
             260                265                270
Cys Asn Glu Cys Gly Thr Ile Phe Arg Gln Lys Gln Tyr Leu Ile Lys 
         275                280                285
His His Asn Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Lys Cys 
     290                295                300
Gly Lys Ala Phe Ser Arg Ile Thr Ser Leu Ile Val His Val Arg Ile 
 305                310                315                320
His Thr Gly Asp Lys Pro Tyr Glu Cys Lys Val Cys Gly Lys Ala Phe 
                 325                330                335
Cys Gln Ser Ser Ser Leu Thr Val His Met Arg Ser His Thr Gly Glu 
             340                345                350
Lys Pro Tyr Gly Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln Phe Ser 
         355                360                365
Thr Leu Ala Leu His Met Arg Ile His Thr Gly Glu Lys Pro Tyr Gln 
     370                375                380
Cys Ser Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser His His Ile Arg 
 385                390                395                400
His Gln Arg Ile His Ile His 
                 405



<210> 8702
<211> 841
<212> DNA
<213> Homo sapiens
<308> AL542378
<400> 8702

cttgccact  aaggctttc  cacattcct  acacgtata  kgtttctct  ctgtgtgac  60
tctctggtg  ctaatgagg  ttgacttct  aatgaaagc  ttcccacac  ctttacatt  120
ataaggttt  tctccagta  ggattctct  atgtataat  aggttttcc  tctggctaa  180
agcttttcc  cactcacta  atttaaagg  cttctttcc  gtatggatg  tctgatgtt  240
aatgaggta  tgcttctgg  tgaaggctc  tccacactg  ttacattca  atggttttt  300
tccagtatg  attttctca  gctcagtga  atatgcttt  ccgttaaag  ctttgccac  360
ttccttaca  gcatagggt  tggttcctg  atgattttt  tggkgtctg  tgatggttg  420
catctgaat  gaaactttt  cacattcat  aggkttctc  ccagtgtga  gtttctgat  480
agaaaggaa  ttttccttc  ggctgaagg  ttttccaca  ttattacat  tatatgcct  540
ctttcctgt  tgacttcta  ggtgtagag  aagaaatga  actcgagag  acactttac  600
acattcagt  cattcatga  atttctctc  agtatgcat  ttcttatgc  ctacaaggt  660
ttgcttcag  ctaaaagtt  ttctacatt  attacattc  taaggtttc  ctccagtat  720
aatttgatc  tgctgaagg  gatctgatt  atgctgaag  ctttccaac  tgcctatca  780
gcatgtgaa  ttaatcagg  gattyccct  gtatctaat  agatgtaat  agggtgaaa  840
c  841



<210> 8703
<211> 292
<212> PRT
<213> Homo sapiens
<308> Q15072
<400> 8703

Met Ser His Leu Ser Gln Gln Lys Ile Tyr Ser Gly Glu Asn Pro Phe 
  1               5                  10                  15
Ala Cys Lys Val Cys Gly Lys Val Phe Ser His Lys Ser Asn Leu Thr 
             20                  25                  30
Glu His Glu His Phe His Thr Arg Glu Lys Pro Phe Glu Cys Asn Glu 
         35                  40                  45
Cys Gly Lys Ala Phe Ser Gln Lys Gln Tyr Val Ile Lys His Gln Asn 
     50                  55                  60
Thr His Thr Gly Glu Lys Leu Phe Glu Cys Asn Glu Cys Gly Lys Ser 
 65                  70                  75                  80
Phe Ser Gln Lys Glu Asn Leu Leu Thr His Gln Lys Ile His Thr Gly 
                 85                  90                  95
Glu Lys Pro Phe Glu Cys Lys Asp Cys Gly Lys Ala Phe Ile Gln Lys 
             100                105                110
Ser Asn Leu Ile Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Phe 
         115                120                125
Val Cys Lys Glu Cys Gly Lys Thr Phe Ser Gly Lys Ser Asn Leu Thr 
     130                135                140
Glu His Glu Lys Ile His Ile Gly Glu Lys Pro Phe Lys Cys Ser Glu 
 145                150                155                160
Cys Gly Thr Ala Phe Gly Gln Lys Lys Tyr Leu Ile Lys His Gln Asn 
                 165                170                175
Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala 
             180                185                190
Phe Ser Gln Arg Thr Ser Leu Ile Val His Val Arg Ile His Ser Gly 
         195                200                205
Asp Lys Pro Tyr Glu Cys Asn Val Cys Gly Lys Ala Phe Ser Gln Ser 
     210                215                220
Ser Ser Leu Thr Val His Val Arg Ser His Thr Gly Glu Lys Pro Tyr 
 225                230                235                240
Gly Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln Phe Ser Thr Leu Ala 
                 245                250                255
Leu His Leu Arg Ile His Thr Gly Lys Lys Pro Tyr Gln Cys Ser Glu 
             260                265                270
Cys Gly Lys Ala Phe Ser Gln Lys Ser His His Ile Arg His Gln Lys 
         275                280                285
Ile His Thr His 
     290



<210> 8704
<211> 3003
<212> DNA
<213> Rattus norvegicus
<308> U57391
<400> 8704

gcgcccgcc  cgagagggt  gcagatagt  cctcggagt  tccgcccca  gggcatgtg  60
agggtgtcc  ccgattagg  tcgggtccg  gtgattgac  acggggccc  gagggtccg  120
acctggagc  cagcctgca  cctccacca  ccgcccttc  ggaatgtca  aactaagcc  180
agaggcagg  gcaccggaa  attgtgact  agccttctt  gcagaagag  aactgagtc  240
ccagtccag  aaccgcagg  ctgttggcg  tcacctcga  tcttctggc  gctttccta  300
ttgctccct  caggctccc  ctgtcctcc  cctggggca  atcatgaat  gtgcccctt  360
cccagagga  ggggttttc  cttctccac  agcgctgcc  ccaccccct  ccccaagtt  420
gcaagagtt  tgtgagtcc  atgcgaggg  tgctgccct  gatcttgct  gccgttttc  480
cctctatct  gcctcccac  cacaatatg  agagccggg  gcagaggct  ccttttctg  540
ccgttttgc  gagctcttc  tgcagcact  cgaagctga  gtggctcgg  cctcgggct  600
actctcccc  cctgtcttg  ctccattga  ccctggtgt  gaaatccca  catcacatg  660
cctgtccct  gagagctgc  gggtgggtg  gcccctggc  gtgttgggc  cttctcgat  720
ttctgagga  ctggctgga  cccttcctt  ctcagtctc  tcctctaca  cgtcctcaa  780
gccgaagct  aagaaacgc  tctccctcc  ctcggtggg  cgttcagtc  gaggttctg  840
ccgaggcat  ctgcagtgg  ggggggctg  tgaatctcc  tcccaagct  ggcctctgg  900
gaccacatc  ggtcctcca  ttctaggtg  aaacagcaa  tccaactcc  ctggtggtg  960
tgggacagt  ggtagggca  tggccaacg  tggcacatc  cctggggag  gatggactc  1020
tcgctttga  aggctaagg  taagtcgtg  agggggaac  ttgagagac  gagcaggag  1080
gatacagag  gaagagctg  tgagtttca  gggggctga  gaggctgcc  ctgacccag  1140
aggagtagg  cgtggagga  gggcagctg  gctgacctc  ggaggagga  ggcagcctc  1200
gtggcagaa  tgtcgatta  tgctccgga  tgaaggaga  ggaggagga  gaagtcgct  1260
ggagttctt  gtaccaccc  aggcatccc  gccccgtct  agcattccc  gttctacta  1320
tactgatgt  cgcacagcc  cagccctgg  gatgcctga  agggagaac  cgtttgtgg  1380
taaggtaga  ggcccttca  agtacatcc  ggagacaac  gatgcactt  atgtgaagg  1440
ctgggtgtc  gacatccaa  agtgcctaa  cccaggacc  tgccctgct  tcagccccc  1500
tcccatgac  cttcccctg  cccctggga  ctccttcct  acaaaggat  acacagaga  1560
cctggagtt  ccctgcctg  atcattcag  gagtctgcc  agccaggat  ttcttctgg  1620
acccagcga  agtaacgac  gcctgtcgc  gggagctta  ggaggcctc  cagaccggc  1680
gtcagcgtc  ttctcccct  gttctgcct  cattgctgc  tcccatttt  actcaatgg  1740
actgcttcc  ccagagttg  cccctcgga  tcccattga  gaggggcct  cagcaggga  1800
agttcatcc  ctctctacc  cgtaccctc  cctggatac  cctgaagca  ccacagggt  1860
attcctctt  caaggggag  cagaggggg  tgaggggga  cagcccctc  caggctacc  1920
ttggttcca  ggcatgctc  ctcggctca  agctgccca  ttagtgtta  aaggaggta  1980
cagctccca  ggtgtcttc  tggtacgcc  gagtgagac  agacgtggt  aatatgtcc  2040
cactttcaa  ttccagggc  aggctaagc  cctgcgttt  tcactaaat  aggagggtc  2100
gtgccgggt  caacatctg  ggttccagt  cattttcga  atgcttgag  acttccggg  2160
gcaccccat  cctctggag  ctggaggct  cagtgatgt  gtccttgtc  gctatgtgc  2220
ctcccagcg  cagcaggaa  ggagcacct  ccgtgatcc  acccagccc  ctgaacccc  2280
tccatggac  gatccccca  atcctgggg  agaagaggc  tcgggggcg  cagaagtgg  2340
ggcagccac  gccgcagca  ccaaagaga  gcaagagaa  gagaaagcg  gcggcggag  2400
ggtccagga  gagctggtc  ccatggctg  gctggtccc  atggctgaa  tggaagagg  2460
catagcacc  ggcactgag  ctcagggtg  tgctggctc  agtggggac  tggaggtgt  2520
cctaatggt  cagctccag  agttaccac  agggggcaa  ggagaagaa  ggggtcacc  2580
ccgagccat  aataaccag  actcatttg  ctgagatac  tgcccaccc  ccattttcc  2640
gctcccagc  ttaagttgt  agactgggc  gggtaagga  acagaggaa  gtgggagtc  2700
cctccctac  tgcttcctg  cccttgtca  ccaagggtg  gtatgttgg  acaagtaga  2760
gttcaagag  ccagttaag  ccccagtta  tacactaca  gtgcccttg  cccgaggcc  2820
aggacttgg  ctccattac  tccctgagg  gctcttatg  tcagcccca  ccctggggg  2880
tgtttcccc  actaataac  cccaaccca  gcaagggtg  gggggaagg  ctgtcagtt  2940
tattaaggt  gttgttgtt  ttttaaacc  aatggaaaa  cataaataa  taaagggtt  3000
atc  3003



<210> 8705
<211> 756
<212> PRT
<213> Rattus norvegicus
<308> AAC52601
<400> 8705

Met Asn Gly Ala Pro Ser Pro Glu Asp Gly Val Phe Pro Ser Pro Pro 
  1               5                  10                  15
Ala Leu Pro Pro Pro Pro Pro Pro Ser Trp Gln Glu Phe Cys Glu Ser 
             20                  25                  30
His Ala Arg Ala Ala Ala Leu Asp Leu Ala Arg Arg Phe Arg Leu Tyr 
         35                  40                  45
Leu Ala Ser His Pro Gln Tyr Ala Glu Pro Gly Ala Glu Ala Ala Phe 
     50                  55                  60
Ser Gly Arg Phe Ala Glu Leu Phe Leu Gln His Phe Glu Ala Glu Val 
 65                  70                  75                  80
Ala Arg Ala Ser Gly Ser Leu Ser Pro Pro Val Leu Ala Pro Leu Ser 
                 85                  90                  95
Pro Gly Val Glu Ile Pro Pro Ser His Asp Leu Ser Leu Glu Ser Cys 
             100                105                110
Arg Val Gly Gly Pro Leu Ala Val Leu Gly Pro Ser Arg Ser Ser Glu 
         115                120                125
Asp Leu Ala Gly Pro Leu Pro Ser Ser Val Ser Ser Ser Thr Thr Ser 
     130                135                140
Ser Lys Pro Lys Leu Lys Lys Arg Phe Ser Leu Arg Ser Val Gly Arg 
 145                150                155                160
Ser Val Arg Gly Ser Val Arg Gly Ile Leu Gln Trp Arg Gly Ala Val 
                 165                170                175
Glu Ser Pro Ser Gln Ala Gly Pro Leu Glu Thr Thr Ser Gly Pro Pro 
             180                185                190
Val Leu Gly Gly Asn Ser Asn Ser Asn Ser Ser Gly Gly Ala Gly Thr 
         195                200                205
Val Gly Arg Ala Leu Ala Asn Asp Gly Thr Ser Pro Gly Glu Arg Trp 
     210                215                220
Thr His Arg Phe Glu Arg Leu Arg Leu Ser Arg Gly Gly Gly Thr Leu 
 225                230                235                240
Arg Asp Gly Ala Gly Val Ile Gln Arg Glu Glu Leu Leu Ser Phe Met 
                 245                250                255
Gly Ala Glu Glu Ala Ala Pro Asp Pro Ala Gly Val Gly Arg Gly Gly 
             260                265                270
Gly Ala Ala Gly Leu Thr Ser Gly Gly Gly Gly Gln Pro Gln Trp Gln 
         275                280                285
Lys Cys Arg Leu Leu Leu Arg Ser Glu Gly Glu Gly Gly Gly Gly Ser 
     290                295                300
Arg Leu Glu Phe Phe Val Pro Pro Lys Ala Ser Arg Pro Arg Leu Ser 
 305                310                315                320
Ile Pro Cys Ser Thr Ile Thr Asp Val Arg Thr Ala Thr Ala Leu Glu 
                 325                330                335
Met Pro Asp Arg Glu Asn Thr Phe Val Val Lys Val Glu Gly Pro Ser 
             340                345                350
Glu Tyr Ile Leu Glu Thr Thr Asp Ala Leu His Val Lys Ala Trp Val 
         355                360                365
Ser Asp Ile Gln Glu Cys Leu Ser Pro Gly Pro Cys Pro Ala Ile Ser 
     370                375                380
Pro Arg Pro Met Thr Leu Pro Leu Ala Pro Gly Thr Ser Phe Leu Thr 
 385                390                395                400
Lys Asp Asn Thr Glu Ser Leu Glu Leu Pro Cys Leu Asn His Ser Glu 
                 405                410                415
Ser Leu Pro Ser Gln Asp Leu Leu Leu Gly Pro Ser Glu Ser Asn Asp 
             420                425                430
Arg Leu Ser Gln Gly Ala Tyr Gly Gly Leu Ser Asp Arg Pro Ser Ala 
         435                440                445
Ser Phe Ser Pro Ser Ser Ala Ser Ile Ala Ala Ser His Phe Asp Ser 
     450                455                460
Met Glu Leu Leu Pro Pro Glu Leu Pro Pro Arg Ile Pro Ile Glu Glu 
 465                470                475                480
Gly Pro Pro Ala Gly Thr Val His Pro Leu Ser Thr Pro Tyr Pro Pro 
                 485                490                495
Leu Asp Thr Pro Glu Ala Ala Thr Gly Ser Phe Leu Phe Gln Gly Glu 
             500                505                510
Ala Glu Gly Gly Glu Gly Asp Gln Pro Leu Ser Gly Tyr Pro Trp Phe 
         515                520                525
His Gly Met Leu Ser Arg Leu Lys Ala Ala Gln Leu Val Leu Glu Gly 
     530                535                540
Gly Thr Ser Ser His Gly Val Phe Leu Val Arg Gln Ser Glu Thr Arg 
 545                550                555                560
Arg Gly Glu Tyr Val Leu Thr Phe Asn Phe Gln Gly Lys Ala Lys His 
                 565                570                575
Leu Arg Leu Ser Leu Asn Glu Glu Gly Gln Cys Arg Val Gln His Leu 
             580                585                590
Trp Phe Gln Ser Ile Phe Asp Met Leu Glu His Phe Arg Val His Pro 
         595                600                605
Ile Pro Leu Glu Ser Gly Gly Ser Ser Asp Val Val Leu Val Ser Tyr 
     610                615                620
Val Pro Ser Gln Arg Gln Gln Glu Arg Ser Thr Ser Arg Asp Pro Thr 
 625                630                635                640
Gln Pro Ser Glu Pro Pro Pro Trp Thr Asp Pro Pro His Pro Gly Ala 
                 645                650                655
Glu Glu Ala Ser Gly Ala Pro Glu Val Ala Ala Ala Thr Ala Ala Ala 
             660                665                670
Ala Lys Glu Arg Gln Glu Lys Glu Lys Ala Gly Gly Gly Gly Val Gln 
         675                680                685
Glu Glu Leu Val Pro Met Ala Glu Leu Val Pro Met Ala Glu Leu Glu 
     690                695                700
Glu Ala Ile Ala Pro Gly Thr Glu Ala Gln Gly Gly Ala Gly Ser Ser 
 705                710                715                720
Gly Asp Leu Glu Val Ser Leu Met Val Gln Leu Gln Gln Leu Pro Leu 
                 725                730                735
Gly Gly Asn Gly Glu Glu Gly Gly His Pro Arg Ala Ile Asn Asn Gln 
             740                745                750
Tyr Ser Phe Val 
         755



<210> 8706
<211> 6043
<212> DNA
<213> Homo sapiens
<308> AB037720
<400> 8706

gacggggtt  caccatgtt  gtcaggctg  tctcaaact  ctgacctca  gccatccgc  60
cgcctcggc  tcccaaagg  ctgggatta  aggcgtgag  cagcgctcc  ggccctgac  120
tcatttttt  tttttctat  tttaaaata  ggattctag  tctgttgcc  gggctggag  180
gccgtggcg  catctcggc  caccgcaat  tctgccttc  ggattcaag  tattctctt  240
cctctgcct  cggagggac  gggactaca  gcgcgcgcc  ccatgcccg  ctaattttt  300
tatttttag  agagacggg  tttcaccat  ttggccagg  tggtctcga  ctcctgacc  360
caggtgatc  acctgcctc  gccttccga  gtgctggga  tacaggcat  agccactgc  420
cccggccct  acctcatta  ttctaccca  cccctcccc  accactacc  ccatcttca  480
ctccagcct  agagatgca  actcctgga  cgcctgccc  tttcctcag  taaaccaag  540
tcgtaagtt  aggctccgc  tccccgcag  gcctcccca  ggtcacccg  ttctttcct  600
gctcagctc  ttggtggcg  tgtccgcgt  cccctccac  gcggggccg  cgctctagg  660
tgcagcggg  cgttcacac  gcctcatca  ctcgctggt  tccggtgct  ggcggctac  720
ctagccctc  gccgggccc  gggactcta  cccctaagg  cggttctct  tggtcgaca  780
cgccccttt  tcccgaatt  cctccggga  gacgctctg  tgggatcca  gcacttccc  840
cgctgcgtc  gtggtcgct  ttaggtgca  ctggagaag  cactgaagc  ctacgagat  900
cacaccgtc  tcggtctcc  ggggtcggc  ccgagtggg  ggatggcgg  agtaagtat  960
aaggtgccc  tccctcccg  cgctgttct  tatggtctc  tccttcagc  acgggaaag  1020
gggtcctga  gcctgcgcg  aaccgggct  ggcgctcgt  gcgtagtgg  tgggggcgc  1080
gggagcggg  gccgccgcc  ccgccgccg  cgccggagc  aacctcggg  accgagatg  1140
aggtgggac  ggaaccgga  cccccctct  caagtacct  ttccctctc  gcgacccgg  1200
cctggcgcc  gagaggatt  ctgggtggg  gtgggcgtg  agggccggg  gctggagag  1260
cactcggcc  cggagagtg  agcagacag  gctggtccc  aggtggatg  ggccccgga  1320
aatgggcgg  tggggggtg  ccagggagt  gggtcggat  ggagtatat  gaccaccgg  1380
cccggaggg  ccgagccga  agcggagcc  gcaccctcc  cctcccgcc  ttcgggaaa  1440
atcagaact  agccaggag  caggtgcac  gggaaaatg  gtctgagtc  tgcttggca  1500
aagagaaac  gagtcacca  cttaggagt  gcagggtca  cgggcctga  gggggctgg  1560
tctgtctgc  gtgcggagg  ttgggtggg  ctgtgtgag  cgaggtggc  gctggctgg  1620
gattggttt  cacttcttg  ctgggttcc  ccgtgctcc  tgactcctg  atctcctga  1680
tgtttctcg  tggtttgga  ttgtccctg  ggttggagc  atctgagct  gtagggtcg  1740
ggcccagga  gaaggggag  gttcaccga  ttacagcct  gctgtaggt  tgaacagga  1800
tctgaggtc  ctgagggtt  ggggaggct  tcctgagct  ctctggccc  agtcctggg  1860
ctgtcacct  ccagtattg  gtggcggga  gagcgctaa  aagagccaa  ggttgtaaa  1920
tccacaccc  gctctgcca  tttctagtt  taagacctt  agagggctc  tcctttctc  1980
aatttctat  ttagaaaat  ggaacaata  tattcttct  ccacatgaa  atagtaaca  2040
tggcagtcg  tcagcggat  cttactttg  gttcagcgc  gacataccc  attccatgt  2100
attctctca  catttcgag  ggagggatc  ttagctttg  ttaacagat  gaaaaacgg  2160
ggctcagag  ggacgtgga  tttgttcaa  ataacatcg  tcataaggt  gctggactg  2220
gtgctcata  ggtggtttg  gccctggtc  gactcaagt  catggcctt  accagaagg  2280
taacctgcc  ttagggcat  ctccccagt  ggagaagag  aaggtgaaa  atcctaggg  2340
cccagctct  cctgtgatg  tttgtttac  tgaggccag  aaagacttg  cctgagcca  2400
cccagtttc  cctctgggg  ccctgcggc  tctggcccc  gactgaagg  ataccaaag  2460
agtgggctg  agctatttc  catctcctt  acgcagtgc  tgggtgctg  actctgggg  2520
cagctttca  gacaattac  gttttggtc  atcatgcat  catcctcat  aatgaatcg  2580
ccccctcca  agagttgga  cctaagatg  gtgaggcag  ctctctaag  tctagaatc  2640
cagctcctc  ctagccccc  gcgagctgg  gcggtgagg  gctatggct  aggctggcc  2700
agccgggcc  tggggacag  gactatgaa  tggggaaaa  agtagactt  gagttctga  2760
acttttctg  gcttcggtt  cctcatctg  tcgagaggt  tttgaaacc  ctcagggaa  2820
ggtaagata  ccaagtggg  gcctctaga  tggctcatg  gaagtgtga  atgaatatt  2880
gaggatccg  tgtagaggg  gggtgatct  gaaaagttc  cttttttag  gggaaggtg  2940
tccaaagcc  tctactgct  gatccaaag  taaggaaag  gggggcaaa  gtggcaggc  3000
cggggcagg  tagacgctg  ggagccagt  ggctggggc  tgcagggtg  caggatctg  3060
gagagggaa  ggaggtgtt  ggctccctt  cccattgct  tctgcggag  ctgaagtag  3120
gtcggacgt  tctggctgg  ggtgggatg  agcctccgg  gcgccctca  cagtgaccc  3180
cgtgtgtgc  tctctcttc  tttcgcagc  gctgccgcc  acccctcgt  ttctggctg  3240
ctccctctt  gtgccccac  ggctccccc  ctccacctc  tggggccca  catgaatgg  3300
gccccttcc  cagaggacg  ggcctcccc  tcgtctccc  cgctgcccc  acccccgcc  3360
cctagttgg  gggagttct  tgagtccca  gcccgggct  cggctctgg  ctttgcccg  3420
cgttttcgc  tctacctgg  ctcccaccc  caatatgcg  ggcccgggg  cgaggctgc  3480
ttctcccgc  gttttgctg  gctcttcct  cagcacttt  aagccgagg  ggcccgggc  3540
tctggctcc  tgtcgccac  catcctggc  cccctgagc  ctggtgcgg  gatttcgcc  3600
catgacctg  cccttgaga  ctgcagggt  ggtgggccc  tggctgtgc  gggcccttc  3660
cgatcatct  aggacctgg  cggccccct  ccttcctca  tctcttcct  ctctacaac  3720
tcctccaag  cgaagctca  gaagcgctt  tccctgcgt  cagtgggtc  ctctgtccg  3780
ggctcagtc  gtggcatcc  gcagtggcg  gggaccgtt  accctccct  ctccgctgg  3840
cccctggag  cctcgtcag  ccccccagt  ttaggtgga  acagcaact  caactcctc  3900
ggcggggct  ggaccgttg  taggggact  gtcagtgat  gaacgtccc  tggggaaag  3960
tggactcac  gttttgaga  gctgagact  agtcgggga  ggggcgcct  gaaggatgg  4020
gcagggatg  tgcagaggg  agagctgct  agtttcatg  gggctgagg  ggcagcccc  4080
gacccagcc  gagtgggcc  gggaggagg  gtggctggg  ctccttcag  gggaggagg  4140
cagcctcag  ggcagaagt  tcgcctgct  cttcgaagt  aaggagaag  aggaggagg  4200
agtcgcctg  agttctttg  accacccaa  gcctctcgg  cccgactca  catcccctg  4260
tcttctatc  cagacgtcc  gacaaccac  gccctggag  tgcctgacc  ggagaacac  4320
tttgtggtt  aggtggaag  tccatccga  tatatcatg  agacagtgg  tgcccagca  4380
gtgaaggcc  gggtgtctg  catccaaga  tgcctgagc  caggaccct  ccctgctac  4440
agtccccgc  ccatgaccc  ccctctggc  cctgggacc  cattcctta  aagggagaa  4500
acagacagc  tggagctgt  ctgcctgaa  cactcggag  gtctaccca  ccaggacct  4560
ctgcttgga  ccagcgaga  caatgaccg  ctgtcgcag  gggcatatg  gggcctctc  4620
gaccgcccc  cggcatcca  ctcccccag  tctgcctcc  ttgccgcct  ccattttga  4680
tcgatggaa  tgcttcccc  agagttgcc  ccccgcatc  ccattgaag  gggaccccc  4740
acagggaca  ttcatcccc  ctcagcccc  taccctccc  tggacactc  ggaaacagc  4800
acagggtcc  tcctgttcc  gggggagcc  gagggcggt  agggggacc  gcccctctc  4860
gggtatcct  ggttccacg  gatgctctc  cggctcaag  ctgcacagt  ggtgctgac  4920
ggcggcact  gctcccacg  tgtcttcct  gtgcgccag  gtgagacaa  gcggggtga  4980
tacgtcctc  ccttcaact  ccagggcaa  gccaagcac  tgcgtttgt  gctgaacga  5040
gagggtcag  gccgggtcc  gcacctgtg  ttccagtcc  ttttcgata  gctcgagca  5100
ttccgggtg  accccatcc  tttggagtc  ggaggctcc  gtgatgttg  ccttgtcag  5160
tatgtccca  cctcccagc  acagcaggg  cgggagcag  ctgggagcc  tgcgggggt  5220
tgcgaggga  atggatgcc  ccccgatgc  tcctgcacc  tcatgccct  cggagcgag  5280
gactgtgta  ccgaccacc  cccatgacc  accccagcc  cctgaaccc  cttcatgga  5340
agatccccc  cagcctggg  cagaagagg  gtcgagggc  ccagaagtg  cggcagcag  5400
agccgcagc  gccaaagag  ggcaagaga  agagaaagc  ggcggtgga  gggtcccgg  5460
agagctggt  cccgtggtt  agctggtcc  cgtggttga  ttggaagag  ccatagccc  5520
aggctcaga  gcccagggc  ctgggtctg  tggggacgc  ggggtgccc  caatggtgc  5580
gctgcagca  tcaccacta  ggggtgatg  agaggaagg  ggccacccc  gggccatta  5640
caaccagta  tccttcgtg  gagccaacc  cacccgctc  acccttttt  aacccccca  5700
ccctgctcg  gagattggg  tgggtaggg  cagaggagg  cgaaatccc  cccccatgc  5760
tcctgaccc  tgttggcca  gggcatctt  gatggtaca  gcagaggct  gggagaggc  5820
cccgtcaca  actacaggt  ccctcccca  ggcagggga  ttgggctcc  tgagctcct  5880
gaggggctc  tctggtcag  cccaccctg  gggccattt  cccattaac  acccccagc  5940
cgaggcagg  tgaggggga  gggctgtca  ttacattaa  gtggttgtt  ttgttgttt  6000
aaacaaaat  gagaagcat  aataaataa  aaggtttat  tcg  6043



<210> 8707
<211> 756
<212> PRT
<213> Homo sapiens
<308> AAF73912
<400> 8707

Met Asn Gly Ala Pro Ser Pro Glu Asp Gly Ala Ser Pro Ser Ser Pro 
  1               5                  10                  15
Pro Leu Pro Pro Pro Pro Pro Pro Ser Trp Arg Glu Phe Cys Glu Ser 
             20                  25                  30
His Ala Arg Ala Ala Ala Leu Asp Phe Ala Arg Arg Phe Arg Leu Tyr 
         35                  40                  45
Leu Ala Ser His Pro Gln Tyr Ala Gly Pro Gly Ala Glu Ala Ala Phe 
     50                  55                  60
Ser Arg Arg Phe Ala Glu Leu Phe Leu Gln His Phe Glu Ala Glu Val 
 65                  70                  75                  80
Ala Arg Ala Ser Gly Ser Leu Ser Pro Pro Ile Leu Ala Pro Leu Ser 
                 85                  90                  95
Pro Gly Ala Glu Ile Ser Pro His Asp Leu Ser Leu Glu Ser Cys Arg 
             100                105                110
Val Gly Gly Pro Leu Ala Val Leu Gly Pro Ser Arg Ser Ser Glu Asp 
         115                120                125
Leu Ala Gly Pro Leu Pro Ser Ser Val Ser Ser Ser Ser Thr Thr Ser 
     130                135                140
Ser Lys Pro Lys Leu Lys Lys Arg Phe Ser Leu Arg Ser Val Gly Arg 
 145                150                155                160
Ser Val Arg Gly Ser Val Arg Gly Ile Leu Gln Trp Arg Gly Thr Val 
                 165                170                175
Asp Pro Pro Ser Ser Ala Gly Pro Leu Glu Thr Ser Ser Gly Pro Pro 
             180                185                190
Val Leu Gly Gly Asn Ser Asn Ser Asn Ser Ser Gly Gly Ala Gly Thr 
         195                200                205
Val Gly Arg Gly Leu Val Ser Asp Gly Thr Ser Pro Gly Glu Arg Trp 
     210                215                220
Thr His Arg Phe Glu Arg Leu Arg Leu Ser Arg Gly Gly Gly Ala Leu 
 225                230                235                240
Lys Asp Gly Ala Gly Met Val Gln Arg Glu Glu Leu Leu Ser Phe Met 
                 245                250                255
Gly Ala Glu Glu Ala Ala Pro Asp Pro Ala Gly Val Gly Arg Gly Gly 
             260                265                270
Gly Val Ala Gly Pro Pro Ser Gly Gly Gly Gly Gln Pro Gln Trp Gln 
         275                280                285
Lys Cys Arg Leu Leu Leu Arg Ser Glu Gly Glu Gly Gly Gly Gly Ser 
     290                295                300
Arg Leu Glu Phe Phe Val Pro Pro Lys Ala Ser Arg Pro Arg Leu Ser 
 305                310                315                320
Ile Pro Cys Ser Ser Ile Thr Asp Val Arg Thr Thr Thr Ala Leu Glu 
                 325                330                335
Met Pro Asp Arg Glu Asn Thr Phe Val Val Lys Val Glu Gly Pro Ser 
             340                345                350
Glu Tyr Ile Met Glu Thr Val Asp Ala Gln His Val Lys Ala Trp Val 
         355                360                365
Ser Asp Ile Gln Glu Cys Leu Ser Pro Gly Pro Cys Pro Ala Thr Ser 
     370                375                380
Pro Arg Pro Met Thr Leu Pro Leu Ala Pro Gly Thr Ser Phe Leu Thr 
 385                390                395                400
Arg Glu Asn Thr Asp Ser Leu Glu Leu Ser Cys Leu Asn His Ser Glu 
                 405                410                415
Ser Leu Pro Ser Gln Asp Leu Leu Leu Gly Pro Ser Glu Ser Asn Asp 
             420                425                430
Arg Leu Ser Gln Gly Ala Tyr Gly Gly Leu Ser Asp Arg Pro Ser Ala 
         435                440                445
Ser Ile Ser Pro Ser Ser Ala Ser Ile Ala Ala Ser His Phe Asp Ser 
     450                455                460
Met Glu Leu Leu Pro Pro Glu Leu Pro Pro Arg Ile Pro Ile Glu Glu 
 465                470                475                480
Gly Pro Pro Ala Gly Thr Val His Pro Leu Ser Ala Pro Tyr Pro Pro 
                 485                490                495
Leu Asp Thr Pro Glu Thr Ala Thr Gly Ser Phe Leu Phe Gln Gly Glu 
             500                505                510
Pro Glu Gly Gly Glu Gly Asp Gln Pro Leu Ser Gly Tyr Pro Trp Phe 
         515                520                525
His Gly Met Leu Ser Arg Leu Lys Ala Ala Gln Leu Val Leu Thr Gly 
     530                535                540
Gly Thr Gly Ser His Gly Val Phe Leu Val Arg Gln Ser Glu Thr Arg 
 545                550                555                560
Arg Gly Glu Tyr Val Leu Thr Phe Asn Phe Gln Gly Lys Ala Lys His 
                 565                570                575
Leu Arg Leu Ser Leu Asn Glu Glu Gly Gln Cys Arg Val Gln His Leu 
             580                585                590
Trp Phe Gln Ser Ile Phe Asp Met Leu Glu His Phe Arg Val His Pro 
         595                600                605
Ile Pro Leu Glu Ser Gly Gly Ser Ser Asp Val Val Leu Val Ser Tyr 
     610                615                620
Val Pro Ser Ser Gln Arg Gln Gln Glu Pro Thr Thr Ser His Asp Pro 
 625                630                635                640
Pro Gln Pro Pro Glu Pro Pro Ser Trp Thr Asp Pro Pro Gln Pro Gly 
                 645                650                655
Ala Glu Glu Ala Ser Arg Ala Pro Glu Val Ala Ala Ala Ala Ala Ala 
             660                665                670
Ala Ala Lys Glu Arg Gln Glu Lys Glu Lys Ala Gly Gly Gly Gly Val 
         675                680                685
Pro Glu Glu Leu Val Pro Val Val Glu Leu Val Pro Val Val Glu Leu 
     690                695                700
Glu Glu Ala Ile Ala Pro Gly Ser Glu Ala Gln Gly Ala Gly Ser Gly 
 705                710                715                720
Gly Asp Ala Gly Val Pro Pro Met Val Gln Leu Gln Gln Ser Pro Leu 
                 725                730                735
Gly Gly Asp Gly Glu Glu Gly Gly His Pro Arg Ala Ile Asn Asn Gln 
             740                745                750
Tyr Ser Phe Val 
         755



<210> 8708
<211> 3003
<212> DNA
<213> Rattus norvegicus
<308> U57391
<400> 8708

gcgcccgcc  cgagagggt  gcagatagt  cctcggagt  tccgcccca  gggcatgtg  60
agggtgtcc  ccgattagg  tcgggtccg  gtgattgac  acggggccc  gagggtccg  120
acctggagc  cagcctgca  cctccacca  ccgcccttc  ggaatgtca  aactaagcc  180
agaggcagg  gcaccggaa  attgtgact  agccttctt  gcagaagag  aactgagtc  240
ccagtccag  aaccgcagg  ctgttggcg  tcacctcga  tcttctggc  gctttccta  300
ttgctccct  caggctccc  ctgtcctcc  cctggggca  atcatgaat  gtgcccctt  360
cccagagga  ggggttttc  cttctccac  agcgctgcc  ccaccccct  ccccaagtt  420
gcaagagtt  tgtgagtcc  atgcgaggg  tgctgccct  gatcttgct  gccgttttc  480
cctctatct  gcctcccac  cacaatatg  agagccggg  gcagaggct  ccttttctg  540
ccgttttgc  gagctcttc  tgcagcact  cgaagctga  gtggctcgg  cctcgggct  600
actctcccc  cctgtcttg  ctccattga  ccctggtgt  gaaatccca  catcacatg  660
cctgtccct  gagagctgc  gggtgggtg  gcccctggc  gtgttgggc  cttctcgat  720
ttctgagga  ctggctgga  cccttcctt  ctcagtctc  tcctctaca  cgtcctcaa  780
gccgaagct  aagaaacgc  tctccctcc  ctcggtggg  cgttcagtc  gaggttctg  840
ccgaggcat  ctgcagtgg  ggggggctg  tgaatctcc  tcccaagct  ggcctctgg  900
gaccacatc  ggtcctcca  ttctaggtg  aaacagcaa  tccaactcc  ctggtggtg  960
tgggacagt  ggtagggca  tggccaacg  tggcacatc  cctggggag  gatggactc  1020
tcgctttga  aggctaagg  taagtcgtg  agggggaac  ttgagagac  gagcaggag  1080
gatacagag  gaagagctg  tgagtttca  gggggctga  gaggctgcc  ctgacccag  1140
aggagtagg  cgtggagga  gggcagctg  gctgacctc  ggaggagga  ggcagcctc  1200
gtggcagaa  tgtcgatta  tgctccgga  tgaaggaga  ggaggagga  gaagtcgct  1260
ggagttctt  gtaccaccc  aggcatccc  gccccgtct  agcattccc  gttctacta  1320
tactgatgt  cgcacagcc  cagccctgg  gatgcctga  agggagaac  cgtttgtgg  1380
taaggtaga  ggcccttca  agtacatcc  ggagacaac  gatgcactt  atgtgaagg  1440
ctgggtgtc  gacatccaa  agtgcctaa  cccaggacc  tgccctgct  tcagccccc  1500
tcccatgac  cttcccctg  cccctggga  ctccttcct  acaaaggat  acacagaga  1560
cctggagtt  ccctgcctg  atcattcag  gagtctgcc  agccaggat  ttcttctgg  1620
acccagcga  agtaacgac  gcctgtcgc  gggagctta  ggaggcctc  cagaccggc  1680
gtcagcgtc  ttctcccct  gttctgcct  cattgctgc  tcccatttt  actcaatgg  1740
actgcttcc  ccagagttg  cccctcgga  tcccattga  gaggggcct  cagcaggga  1800
agttcatcc  ctctctacc  cgtaccctc  cctggatac  cctgaagca  ccacagggt  1860
attcctctt  caaggggag  cagaggggg  tgaggggga  cagcccctc  caggctacc  1920
ttggttcca  ggcatgctc  ctcggctca  agctgccca  ttagtgtta  aaggaggta  1980
cagctccca  ggtgtcttc  tggtacgcc  gagtgagac  agacgtggt  aatatgtcc  2040
cactttcaa  ttccagggc  aggctaagc  cctgcgttt  tcactaaat  aggagggtc  2100
gtgccgggt  caacatctg  ggttccagt  cattttcga  atgcttgag  acttccggg  2160
gcaccccat  cctctggag  ctggaggct  cagtgatgt  gtccttgtc  gctatgtgc  2220
ctcccagcg  cagcaggaa  ggagcacct  ccgtgatcc  acccagccc  ctgaacccc  2280
tccatggac  gatccccca  atcctgggg  agaagaggc  tcgggggcg  cagaagtgg  2340
ggcagccac  gccgcagca  ccaaagaga  gcaagagaa  gagaaagcg  gcggcggag  2400
ggtccagga  gagctggtc  ccatggctg  gctggtccc  atggctgaa  tggaagagg  2460
catagcacc  ggcactgag  ctcagggtg  tgctggctc  agtggggac  tggaggtgt  2520
cctaatggt  cagctccag  agttaccac  agggggcaa  ggagaagaa  ggggtcacc  2580
ccgagccat  aataaccag  actcatttg  ctgagatac  tgcccaccc  ccattttcc  2640
gctcccagc  ttaagttgt  agactgggc  gggtaagga  acagaggaa  gtgggagtc  2700
cctccctac  tgcttcctg  cccttgtca  ccaagggtg  gtatgttgg  acaagtaga  2760
gttcaagag  ccagttaag  ccccagtta  tacactaca  gtgcccttg  cccgaggcc  2820
aggacttgg  ctccattac  tccctgagg  gctcttatg  tcagcccca  ccctggggg  2880
tgtttcccc  actaataac  cccaaccca  gcaagggtg  gggggaagg  ctgtcagtt  2940
tattaaggt  gttgttgtt  ttttaaacc  aatggaaaa  cataaataa  taaagggtt  3000
atc  3003



<210> 8709
<211> 756
<212> PRT
<213> Rattus norvegicus
<308> AAC52601
<400> 8709

Met Asn Gly Ala Pro Ser Pro Glu Asp Gly Val Phe Pro Ser Pro Pro 
  1               5                  10                  15
Ala Leu Pro Pro Pro Pro Pro Pro Ser Trp Gln Glu Phe Cys Glu Ser 
             20                  25                  30
His Ala Arg Ala Ala Ala Leu Asp Leu Ala Arg Arg Phe Arg Leu Tyr 
         35                  40                  45
Leu Ala Ser His Pro Gln Tyr Ala Glu Pro Gly Ala Glu Ala Ala Phe 
     50                  55                  60
Ser Gly Arg Phe Ala Glu Leu Phe Leu Gln His Phe Glu Ala Glu Val 
 65                  70                  75                  80
Ala Arg Ala Ser Gly Ser Leu Ser Pro Pro Val Leu Ala Pro Leu Ser 
                 85                  90                  95
Pro Gly Val Glu Ile Pro Pro Ser His Asp Leu Ser Leu Glu Ser Cys 
             100                105                110
Arg Val Gly Gly Pro Leu Ala Val Leu Gly Pro Ser Arg Ser Ser Glu 
         115                120                125
Asp Leu Ala Gly Pro Leu Pro Ser Ser Val Ser Ser Ser Thr Thr Ser 
     130                135                140
Ser Lys Pro Lys Leu Lys Lys Arg Phe Ser Leu Arg Ser Val Gly Arg 
 145                150                155                160
Ser Val Arg Gly Ser Val Arg Gly Ile Leu Gln Trp Arg Gly Ala Val 
                 165                170                175
Glu Ser Pro Ser Gln Ala Gly Pro Leu Glu Thr Thr Ser Gly Pro Pro 
             180                185                190
Val Leu Gly Gly Asn Ser Asn Ser Asn Ser Ser Gly Gly Ala Gly Thr 
         195                200                205
Val Gly Arg Ala Leu Ala Asn Asp Gly Thr Ser Pro Gly Glu Arg Trp 
     210                215                220
Thr His Arg Phe Glu Arg Leu Arg Leu Ser Arg Gly Gly Gly Thr Leu 
 225                230                235                240
Arg Asp Gly Ala Gly Val Ile Gln Arg Glu Glu Leu Leu Ser Phe Met 
                 245                250                255
Gly Ala Glu Glu Ala Ala Pro Asp Pro Ala Gly Val Gly Arg Gly Gly 
             260                265                270
Gly Ala Ala Gly Leu Thr Ser Gly Gly Gly Gly Gln Pro Gln Trp Gln 
         275                280                285
Lys Cys Arg Leu Leu Leu Arg Ser Glu Gly Glu Gly Gly Gly Gly Ser 
     290                295                300
Arg Leu Glu Phe Phe Val Pro Pro Lys Ala Ser Arg Pro Arg Leu Ser 
 305                310                315                320
Ile Pro Cys Ser Thr Ile Thr Asp Val Arg Thr Ala Thr Ala Leu Glu 
                 325                330                335
Met Pro Asp Arg Glu Asn Thr Phe Val Val Lys Val Glu Gly Pro Ser 
             340                345                350
Glu Tyr Ile Leu Glu Thr Thr Asp Ala Leu His Val Lys Ala Trp Val 
         355                360                365
Ser Asp Ile Gln Glu Cys Leu Ser Pro Gly Pro Cys Pro Ala Ile Ser 
     370                375                380
Pro Arg Pro Met Thr Leu Pro Leu Ala Pro Gly Thr Ser Phe Leu Thr 
 385                390                395                400
Lys Asp Asn Thr Glu Ser Leu Glu Leu Pro Cys Leu Asn His Ser Glu 
                 405                410                415
Ser Leu Pro Ser Gln Asp Leu Leu Leu Gly Pro Ser Glu Ser Asn Asp 
             420                425                430
Arg Leu Ser Gln Gly Ala Tyr Gly Gly Leu Ser Asp Arg Pro Ser Ala 
         435                440                445
Ser Phe Ser Pro Ser Ser Ala Ser Ile Ala Ala Ser His Phe Asp Ser 
     450                455                460
Met Glu Leu Leu Pro Pro Glu Leu Pro Pro Arg Ile Pro Ile Glu Glu 
 465                470                475                480
Gly Pro Pro Ala Gly Thr Val His Pro Leu Ser Thr Pro Tyr Pro Pro 
                 485                490                495
Leu Asp Thr Pro Glu Ala Ala Thr Gly Ser Phe Leu Phe Gln Gly Glu 
             500                505                510
Ala Glu Gly Gly Glu Gly Asp Gln Pro Leu Ser Gly Tyr Pro Trp Phe 
         515                520                525
His Gly Met Leu Ser Arg Leu Lys Ala Ala Gln Leu Val Leu Glu Gly 
     530                535                540
Gly Thr Ser Ser His Gly Val Phe Leu Val Arg Gln Ser Glu Thr Arg 
 545                550                555                560
Arg Gly Glu Tyr Val Leu Thr Phe Asn Phe Gln Gly Lys Ala Lys His 
                 565                570                575
Leu Arg Leu Ser Leu Asn Glu Glu Gly Gln Cys Arg Val Gln His Leu 
             580                585                590
Trp Phe Gln Ser Ile Phe Asp Met Leu Glu His Phe Arg Val His Pro 
         595                600                605
Ile Pro Leu Glu Ser Gly Gly Ser Ser Asp Val Val Leu Val Ser Tyr 
     610                615                620
Val Pro Ser Gln Arg Gln Gln Glu Arg Ser Thr Ser Arg Asp Pro Thr 
 625                630                635                640
Gln Pro Ser Glu Pro Pro Pro Trp Thr Asp Pro Pro His Pro Gly Ala 
                 645                650                655
Glu Glu Ala Ser Gly Ala Pro Glu Val Ala Ala Ala Thr Ala Ala Ala 
             660                665                670
Ala Lys Glu Arg Gln Glu Lys Glu Lys Ala Gly Gly Gly Gly Val Gln 
         675                680                685
Glu Glu Leu Val Pro Met Ala Glu Leu Val Pro Met Ala Glu Leu Glu 
     690                695                700
Glu Ala Ile Ala Pro Gly Thr Glu Ala Gln Gly Gly Ala Gly Ser Ser 
 705                710                715                720
Gly Asp Leu Glu Val Ser Leu Met Val Gln Leu Gln Gln Leu Pro Leu 
                 725                730                735
Gly Gly Asn Gly Glu Glu Gly Gly His Pro Arg Ala Ile Asn Asn Gln 
             740                745                750
Tyr Ser Phe Val 
         755



<210> 8710
<211> 6043
<212> DNA
<213> Homo sapiens
<308> AB037720
<400> 8710

gacggggtt  caccatgtt  gtcaggctg  tctcaaact  ctgacctca  gccatccgc  60
cgcctcggc  tcccaaagg  ctgggatta  aggcgtgag  cagcgctcc  ggccctgac  120
tcatttttt  tttttctat  tttaaaata  ggattctag  tctgttgcc  gggctggag  180
gccgtggcg  catctcggc  caccgcaat  tctgccttc  ggattcaag  tattctctt  240
cctctgcct  cggagggac  gggactaca  gcgcgcgcc  ccatgcccg  ctaattttt  300
tatttttag  agagacggg  tttcaccat  ttggccagg  tggtctcga  ctcctgacc  360
caggtgatc  acctgcctc  gccttccga  gtgctggga  tacaggcat  agccactgc  420
cccggccct  acctcatta  ttctaccca  cccctcccc  accactacc  ccatcttca  480
ctccagcct  agagatgca  actcctgga  cgcctgccc  tttcctcag  taaaccaag  540
tcgtaagtt  aggctccgc  tccccgcag  gcctcccca  ggtcacccg  ttctttcct  600
gctcagctc  ttggtggcg  tgtccgcgt  cccctccac  gcggggccg  cgctctagg  660
tgcagcggg  cgttcacac  gcctcatca  ctcgctggt  tccggtgct  ggcggctac  720
ctagccctc  gccgggccc  gggactcta  cccctaagg  cggttctct  tggtcgaca  780
cgccccttt  tcccgaatt  cctccggga  gacgctctg  tgggatcca  gcacttccc  840
cgctgcgtc  gtggtcgct  ttaggtgca  ctggagaag  cactgaagc  ctacgagat  900
cacaccgtc  tcggtctcc  ggggtcggc  ccgagtggg  ggatggcgg  agtaagtat  960
aaggtgccc  tccctcccg  cgctgttct  tatggtctc  tccttcagc  acgggaaag  1020
gggtcctga  gcctgcgcg  aaccgggct  ggcgctcgt  gcgtagtgg  tgggggcgc  1080
gggagcggg  gccgccgcc  ccgccgccg  cgccggagc  aacctcggg  accgagatg  1140
aggtgggac  ggaaccgga  cccccctct  caagtacct  ttccctctc  gcgacccgg  1200
cctggcgcc  gagaggatt  ctgggtggg  gtgggcgtg  agggccggg  gctggagag  1260
cactcggcc  cggagagtg  agcagacag  gctggtccc  aggtggatg  ggccccgga  1320
aatgggcgg  tggggggtg  ccagggagt  gggtcggat  ggagtatat  gaccaccgg  1380
cccggaggg  ccgagccga  agcggagcc  gcaccctcc  cctcccgcc  ttcgggaaa  1440
atcagaact  agccaggag  caggtgcac  gggaaaatg  gtctgagtc  tgcttggca  1500
aagagaaac  gagtcacca  cttaggagt  gcagggtca  cgggcctga  gggggctgg  1560
tctgtctgc  gtgcggagg  ttgggtggg  ctgtgtgag  cgaggtggc  gctggctgg  1620
gattggttt  cacttcttg  ctgggttcc  ccgtgctcc  tgactcctg  atctcctga  1680
tgtttctcg  tggtttgga  ttgtccctg  ggttggagc  atctgagct  gtagggtcg  1740
ggcccagga  gaaggggag  gttcaccga  ttacagcct  gctgtaggt  tgaacagga  1800
tctgaggtc  ctgagggtt  ggggaggct  tcctgagct  ctctggccc  agtcctggg  1860
ctgtcacct  ccagtattg  gtggcggga  gagcgctaa  aagagccaa  ggttgtaaa  1920
tccacaccc  gctctgcca  tttctagtt  taagacctt  agagggctc  tcctttctc  1980
aatttctat  ttagaaaat  ggaacaata  tattcttct  ccacatgaa  atagtaaca  2040
tggcagtcg  tcagcggat  cttactttg  gttcagcgc  gacataccc  attccatgt  2100
attctctca  catttcgag  ggagggatc  ttagctttg  ttaacagat  gaaaaacgg  2160
ggctcagag  ggacgtgga  tttgttcaa  ataacatcg  tcataaggt  gctggactg  2220
gtgctcata  ggtggtttg  gccctggtc  gactcaagt  catggcctt  accagaagg  2280
taacctgcc  ttagggcat  ctccccagt  ggagaagag  aaggtgaaa  atcctaggg  2340
cccagctct  cctgtgatg  tttgtttac  tgaggccag  aaagacttg  cctgagcca  2400
cccagtttc  cctctgggg  ccctgcggc  tctggcccc  gactgaagg  ataccaaag  2460
agtgggctg  agctatttc  catctcctt  acgcagtgc  tgggtgctg  actctgggg  2520
cagctttca  gacaattac  gttttggtc  atcatgcat  catcctcat  aatgaatcg  2580
ccccctcca  agagttgga  cctaagatg  gtgaggcag  ctctctaag  tctagaatc  2640
cagctcctc  ctagccccc  gcgagctgg  gcggtgagg  gctatggct  aggctggcc  2700
agccgggcc  tggggacag  gactatgaa  tggggaaaa  agtagactt  gagttctga  2760
acttttctg  gcttcggtt  cctcatctg  tcgagaggt  tttgaaacc  ctcagggaa  2820
ggtaagata  ccaagtggg  gcctctaga  tggctcatg  gaagtgtga  atgaatatt  2880
gaggatccg  tgtagaggg  gggtgatct  gaaaagttc  cttttttag  gggaaggtg  2940
tccaaagcc  tctactgct  gatccaaag  taaggaaag  gggggcaaa  gtggcaggc  3000
cggggcagg  tagacgctg  ggagccagt  ggctggggc  tgcagggtg  caggatctg  3060
gagagggaa  ggaggtgtt  ggctccctt  cccattgct  tctgcggag  ctgaagtag  3120
gtcggacgt  tctggctgg  ggtgggatg  agcctccgg  gcgccctca  cagtgaccc  3180
cgtgtgtgc  tctctcttc  tttcgcagc  gctgccgcc  acccctcgt  ttctggctg  3240
ctccctctt  gtgccccac  ggctccccc  ctccacctc  tggggccca  catgaatgg  3300
gccccttcc  cagaggacg  ggcctcccc  tcgtctccc  cgctgcccc  acccccgcc  3360
cctagttgg  gggagttct  tgagtccca  gcccgggct  cggctctgg  ctttgcccg  3420
cgttttcgc  tctacctgg  ctcccaccc  caatatgcg  ggcccgggg  cgaggctgc  3480
ttctcccgc  gttttgctg  gctcttcct  cagcacttt  aagccgagg  ggcccgggc  3540
tctggctcc  tgtcgccac  catcctggc  cccctgagc  ctggtgcgg  gatttcgcc  3600
catgacctg  cccttgaga  ctgcagggt  ggtgggccc  tggctgtgc  gggcccttc  3660
cgatcatct  aggacctgg  cggccccct  ccttcctca  tctcttcct  ctctacaac  3720
tcctccaag  cgaagctca  gaagcgctt  tccctgcgt  cagtgggtc  ctctgtccg  3780
ggctcagtc  gtggcatcc  gcagtggcg  gggaccgtt  accctccct  ctccgctgg  3840
cccctggag  cctcgtcag  ccccccagt  ttaggtgga  acagcaact  caactcctc  3900
ggcggggct  ggaccgttg  taggggact  gtcagtgat  gaacgtccc  tggggaaag  3960
tggactcac  gttttgaga  gctgagact  agtcgggga  ggggcgcct  gaaggatgg  4020
gcagggatg  tgcagaggg  agagctgct  agtttcatg  gggctgagg  ggcagcccc  4080
gacccagcc  gagtgggcc  gggaggagg  gtggctggg  ctccttcag  gggaggagg  4140
cagcctcag  ggcagaagt  tcgcctgct  cttcgaagt  aaggagaag  aggaggagg  4200
agtcgcctg  agttctttg  accacccaa  gcctctcgg  cccgactca  catcccctg  4260
tcttctatc  cagacgtcc  gacaaccac  gccctggag  tgcctgacc  ggagaacac  4320
tttgtggtt  aggtggaag  tccatccga  tatatcatg  agacagtgg  tgcccagca  4380
gtgaaggcc  gggtgtctg  catccaaga  tgcctgagc  caggaccct  ccctgctac  4440
agtccccgc  ccatgaccc  ccctctggc  cctgggacc  cattcctta  aagggagaa  4500
acagacagc  tggagctgt  ctgcctgaa  cactcggag  gtctaccca  ccaggacct  4560
ctgcttgga  ccagcgaga  caatgaccg  ctgtcgcag  gggcatatg  gggcctctc  4620
gaccgcccc  cggcatcca  ctcccccag  tctgcctcc  ttgccgcct  ccattttga  4680
tcgatggaa  tgcttcccc  agagttgcc  ccccgcatc  ccattgaag  gggaccccc  4740
acagggaca  ttcatcccc  ctcagcccc  taccctccc  tggacactc  ggaaacagc  4800
acagggtcc  tcctgttcc  gggggagcc  gagggcggt  agggggacc  gcccctctc  4860
gggtatcct  ggttccacg  gatgctctc  cggctcaag  ctgcacagt  ggtgctgac  4920
ggcggcact  gctcccacg  tgtcttcct  gtgcgccag  gtgagacaa  gcggggtga  4980
tacgtcctc  ccttcaact  ccagggcaa  gccaagcac  tgcgtttgt  gctgaacga  5040
gagggtcag  gccgggtcc  gcacctgtg  ttccagtcc  ttttcgata  gctcgagca  5100
ttccgggtg  accccatcc  tttggagtc  ggaggctcc  gtgatgttg  ccttgtcag  5160
tatgtccca  cctcccagc  acagcaggg  cgggagcag  ctgggagcc  tgcgggggt  5220
tgcgaggga  atggatgcc  ccccgatgc  tcctgcacc  tcatgccct  cggagcgag  5280
gactgtgta  ccgaccacc  cccatgacc  accccagcc  cctgaaccc  cttcatgga  5340
agatccccc  cagcctggg  cagaagagg  gtcgagggc  ccagaagtg  cggcagcag  5400
agccgcagc  gccaaagag  ggcaagaga  agagaaagc  ggcggtgga  gggtcccgg  5460
agagctggt  cccgtggtt  agctggtcc  cgtggttga  ttggaagag  ccatagccc  5520
aggctcaga  gcccagggc  ctgggtctg  tggggacgc  ggggtgccc  caatggtgc  5580
gctgcagca  tcaccacta  ggggtgatg  agaggaagg  ggccacccc  gggccatta  5640
caaccagta  tccttcgtg  gagccaacc  cacccgctc  acccttttt  aacccccca  5700
ccctgctcg  gagattggg  tgggtaggg  cagaggagg  cgaaatccc  cccccatgc  5760
tcctgaccc  tgttggcca  gggcatctt  gatggtaca  gcagaggct  gggagaggc  5820
cccgtcaca  actacaggt  ccctcccca  ggcagggga  ttgggctcc  tgagctcct  5880
gaggggctc  tctggtcag  cccaccctg  gggccattt  cccattaac  acccccagc  5940
cgaggcagg  tgaggggga  gggctgtca  ttacattaa  gtggttgtt  ttgttgttt  6000
aaacaaaat  gagaagcat  aataaataa  aaggtttat  tcg  6043



<210> 8711
<211> 756
<212> PRT
<213> Homo sapiens
<308> AAF73912
<400> 8711

Met Asn Gly Ala Pro Ser Pro Glu Asp Gly Ala Ser Pro Ser Ser Pro 
  1               5                  10                  15
Pro Leu Pro Pro Pro Pro Pro Pro Ser Trp Arg Glu Phe Cys Glu Ser 
             20                  25                  30
His Ala Arg Ala Ala Ala Leu Asp Phe Ala Arg Arg Phe Arg Leu Tyr 
         35                  40                  45
Leu Ala Ser His Pro Gln Tyr Ala Gly Pro Gly Ala Glu Ala Ala Phe 
     50                  55                  60
Ser Arg Arg Phe Ala Glu Leu Phe Leu Gln His Phe Glu Ala Glu Val 
 65                  70                  75                  80
Ala Arg Ala Ser Gly Ser Leu Ser Pro Pro Ile Leu Ala Pro Leu Ser 
                 85                  90                  95
Pro Gly Ala Glu Ile Ser Pro His Asp Leu Ser Leu Glu Ser Cys Arg 
             100                105                110
Val Gly Gly Pro Leu Ala Val Leu Gly Pro Ser Arg Ser Ser Glu Asp 
         115                120                125
Leu Ala Gly Pro Leu Pro Ser Ser Val Ser Ser Ser Ser Thr Thr Ser 
     130                135                140
Ser Lys Pro Lys Leu Lys Lys Arg Phe Ser Leu Arg Ser Val Gly Arg 
 145                150                155                160
Ser Val Arg Gly Ser Val Arg Gly Ile Leu Gln Trp Arg Gly Thr Val 
                 165                170                175
Asp Pro Pro Ser Ser Ala Gly Pro Leu Glu Thr Ser Ser Gly Pro Pro 
             180                185                190
Val Leu Gly Gly Asn Ser Asn Ser Asn Ser Ser Gly Gly Ala Gly Thr 
         195                200                205
Val Gly Arg Gly Leu Val Ser Asp Gly Thr Ser Pro Gly Glu Arg Trp 
     210                215                220
Thr His Arg Phe Glu Arg Leu Arg Leu Ser Arg Gly Gly Gly Ala Leu 
 225                230                235                240
Lys Asp Gly Ala Gly Met Val Gln Arg Glu Glu Leu Leu Ser Phe Met 
                 245                250                255
Gly Ala Glu Glu Ala Ala Pro Asp Pro Ala Gly Val Gly Arg Gly Gly 
             260                265                270
Gly Val Ala Gly Pro Pro Ser Gly Gly Gly Gly Gln Pro Gln Trp Gln 
         275                280                285
Lys Cys Arg Leu Leu Leu Arg Ser Glu Gly Glu Gly Gly Gly Gly Ser 
     290                295                300
Arg Leu Glu Phe Phe Val Pro Pro Lys Ala Ser Arg Pro Arg Leu Ser 
 305                310                315                320
Ile Pro Cys Ser Ser Ile Thr Asp Val Arg Thr Thr Thr Ala Leu Glu 
                 325                330                335
Met Pro Asp Arg Glu Asn Thr Phe Val Val Lys Val Glu Gly Pro Ser 
             340                345                350
Glu Tyr Ile Met Glu Thr Val Asp Ala Gln His Val Lys Ala Trp Val 
         355                360                365
Ser Asp Ile Gln Glu Cys Leu Ser Pro Gly Pro Cys Pro Ala Thr Ser 
     370                375                380
Pro Arg Pro Met Thr Leu Pro Leu Ala Pro Gly Thr Ser Phe Leu Thr 
 385                390                395                400
Arg Glu Asn Thr Asp Ser Leu Glu Leu Ser Cys Leu Asn His Ser Glu 
                 405                410                415
Ser Leu Pro Ser Gln Asp Leu Leu Leu Gly Pro Ser Glu Ser Asn Asp 
             420                425                430
Arg Leu Ser Gln Gly Ala Tyr Gly Gly Leu Ser Asp Arg Pro Ser Ala 
         435                440                445
Ser Ile Ser Pro Ser Ser Ala Ser Ile Ala Ala Ser His Phe Asp Ser 
     450                455                460
Met Glu Leu Leu Pro Pro Glu Leu Pro Pro Arg Ile Pro Ile Glu Glu 
 465                470                475                480
Gly Pro Pro Ala Gly Thr Val His Pro Leu Ser Ala Pro Tyr Pro Pro 
                 485                490                495
Leu Asp Thr Pro Glu Thr Ala Thr Gly Ser Phe Leu Phe Gln Gly Glu 
             500                505                510
Pro Glu Gly Gly Glu Gly Asp Gln Pro Leu Ser Gly Tyr Pro Trp Phe 
         515                520                525
His Gly Met Leu Ser Arg Leu Lys Ala Ala Gln Leu Val Leu Thr Gly 
     530                535                540
Gly Thr Gly Ser His Gly Val Phe Leu Val Arg Gln Ser Glu Thr Arg 
 545                550                555                560
Arg Gly Glu Tyr Val Leu Thr Phe Asn Phe Gln Gly Lys Ala Lys His 
                 565                570                575
Leu Arg Leu Ser Leu Asn Glu Glu Gly Gln Cys Arg Val Gln His Leu 
             580                585                590
Trp Phe Gln Ser Ile Phe Asp Met Leu Glu His Phe Arg Val His Pro 
         595                600                605
Ile Pro Leu Glu Ser Gly Gly Ser Ser Asp Val Val Leu Val Ser Tyr 
     610                615                620
Val Pro Ser Ser Gln Arg Gln Gln Glu Pro Thr Thr Ser His Asp Pro 
 625                630                635                640
Pro Gln Pro Pro Glu Pro Pro Ser Trp Thr Asp Pro Pro Gln Pro Gly 
                 645                650                655
Ala Glu Glu Ala Ser Arg Ala Pro Glu Val Ala Ala Ala Ala Ala Ala 
             660                665                670
Ala Ala Lys Glu Arg Gln Glu Lys Glu Lys Ala Gly Gly Gly Gly Val 
         675                680                685
Pro Glu Glu Leu Val Pro Val Val Glu Leu Val Pro Val Val Glu Leu 
     690                695                700
Glu Glu Ala Ile Ala Pro Gly Ser Glu Ala Gln Gly Ala Gly Ser Gly 
 705                710                715                720
Gly Asp Ala Gly Val Pro Pro Met Val Gln Leu Gln Gln Ser Pro Leu 
                 725                730                735
Gly Gly Asp Gly Glu Glu Gly Gly His Pro Arg Ala Ile Asn Asn Gln 
             740                745                750
Tyr Ser Phe Val 
         755



<210> 8712
<211> 1780
<212> DNA
<213> Rattus norvegicus
<308> U57715
<400> 8712

cgcgcgggc  ggtctatgg  gagggacga  gagtcccac  ctctctgcg  caacggttg  60
ctgagaaag  gtcatgacg  cacacaggg  cctcgaaga  ggcaggtga  tggctagag  120
agtgagcac  aaacagcag  gacgttggg  tcagacccc  cccctttcc  tggagcgcg  180
agactcgct  cggaagctt  ggccaatca  aaggaagac  caaggatga  atggtgatg  240
catgcagcc  gaggtaaaa  gacaaggtg  cttattcga  atgtcaaaa  cttgtttcc  300
gagctctct  actgctctc  cgtactcaa  aatagtggg  acagagccg  cctggggag  360
cttggcttc  agagacgct  gattataaa  aaagccagg  gtcccggtc  ccaaaatgg  420
gaggagcca  tgaagaaac  ggcccagtt  cctctttaa  acccacccc  gagcgctgg  480
cccgcctca  gccgttgct  ctgcgaccc  cccccttcc  ctcgccccc  ggctgggct  540
gggctcccg  ttccgcgcc  ctggctacg  gggtacggc  ccctagcca  cactacttg  600
ggccttctg  tcaagatcc  tccaggcac  gcggatgga  gcgtggggg  gccttggaa  660
ctcagacta  ttttgaatc  ctgccctgc  agtcactag  ttgtggctt  gagtctgac  720
agatgtacc  ggtcccatt  acactggac  gggatggga  cctagtccg  ctccgcttc  780
ctatggtgg  cctgatcac  gtctgctgt  cacttgtcg  cttcttctt  tgcatcctg  840
ggtccctgc  cttccactt  aaggagaca  catctacac  ctgtggggt  cccaattac  900
tgccatcag  gagctctgc  attggtggg  aggttcccc  gcgctacgt  tggcgtttc  960
gcattggcc  gcactcggc  ccccgcttc  tgacagcct  cgcctattg  aaccactac  1020
tcagctgtg  atccccgtg  ccgggttac  gccttctct  ccgcctcaa  ttcagtctc  1080
atgtggtgg  gaacctggc  ctgctcgtg  tcacctatg  ctcctcctc  gaggacttc  1140
ccatccatg  aaatgcttt  attgtgttt  tcgcggcct  cctcagtta  atgctcctc  1200
cctgcattc  ctggcggct  accaagaag  acacagatc  caagtccta  agctggaaa  1260
aacggctct  catcatcaa  ttcatctcc  tcttctcgg  gctggctgt  tacttccgg  1320
acaacatgt  ttgtgaggc  ggagtgtac  ccatctttg  catcctgga  tacactgtg  1380
tcctaacca  catggcgtt  cacatgaca  cctggtggg  cttcgggaa  aaagagctg  1440
taataacct  tcagcctgg  aaaagagat  ctaaacccc  tctctgatc  tggaaaaca  1500
gaaaccact  tggccttcc  tatctcagt  tcctctctg  gcccttctc  gtctgggga  1560
tgggagaga  gagcaggaa  ggtaggaca  ggctgaccc  agcactgct  acttctccc  1620
ccctctcat  tctcatggg  gtcttcaag  agcatcact  ctcactgaa  ggtcctaaa  1680
agctgagct  gcaggaaag  cctaccact  ggtgctaag  aaaaaaaaa  aaaaaaaaa  1740
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaaa  1780



<210> 8713
<211> 254
<212> PRT
<213> Rattus norvegicus
<308> AAB07050
<400> 8713

Met Tyr Gln Val Pro Leu Thr Leu Asp Arg Asp Gly Thr Leu Val Arg 
  1               5                  10                  15
Leu Arg Phe Thr Met Val Ala Leu Ile Thr Val Cys Cys Pro Leu Val 
             20                  25                  30
Ala Phe Phe Phe Cys Ile Leu Trp Ser Leu Leu Phe His Phe Lys Glu 
         35                  40                  45
Thr Thr Ser Thr His Cys Gly Val Pro Asn Tyr Leu Pro Ser Val Ser 
     50                  55                  60
Ser Ala Ile Gly Gly Glu Val Pro Gln Arg Tyr Val Trp Arg Phe Cys 
 65                  70                  75                  80
Ile Gly Leu His Ser Ala Pro Arg Phe Leu Thr Ala Phe Ala Tyr Trp 
                 85                  90                  95
Asn His Tyr Leu Ser Cys Ala Ser Pro Cys Pro Gly Tyr Arg Leu Leu 
             100                105                110
Cys Arg Leu Asn Phe Ser Leu Asn Val Val Glu Asn Leu Ala Leu Leu 
         115                120                125
Val Leu Thr Tyr Val Ser Ser Ser Glu Asp Phe Thr Ile His Glu Asn 
     130                135                140
Ala Phe Ile Val Phe Ile Ala Ala Ser Leu Ser Tyr Met Leu Leu Thr 
 145                150                155                160
Cys Ile Leu Trp Arg Leu Thr Lys Lys His Thr Asp Arg Lys Ser Tyr 
                 165                170                175
Ser Trp Lys Gln Arg Leu Phe Ile Ile Asn Phe Ile Ser Phe Phe Ser 
             180                185                190
Ala Leu Ala Val Tyr Phe Arg His Asn Met Tyr Cys Glu Ala Gly Val 
         195                200                205
Tyr Thr Ile Phe Ala Ile Leu Glu Tyr Thr Val Val Leu Thr Asn Met 
     210                215                220
Ala Phe His Met Thr Ala Trp Trp Asp Phe Gly Asn Lys Glu Leu Leu 
 225                230                235                240
Ile Thr Ser Gln Pro Gly Lys Arg Asp Ser Lys Pro Arg Leu 
                 245                250



<210> 8714
<211> 1353
<212> DNA
<213> Rattus norvegicus
<308> U59241
<400> 8714

ccccgcatc  cggtcacca  ttcaggaga  aaagacaca  cctcccaca  tgtcctaca  60
acgagagct  gagaaatat  gagacctgg  tgaggatga  atcctgggg  ccctcacag  120
ggaggagct  aggacactg  aaaacgagc  ggatgagct  gaccctgat  atgcactgc  180
ccctgcagg  ctgaggcag  aggatcaga  caccaaggc  cccacaggc  cctttaaaa  240
agaggagct  ttggaccac  tggaaaagc  agcgaagga  tttaaggac  gagaagacc  300
ggttcccta  acaggggag  aacgaggaa  gatctgggt  cccaagcag  agccaatgg  360
tcccgtgct  gagagcgtg  cgctggagc  ggaactgga  gaggcccta  caaatgcct  420
agatgccga  ctatgtgac  ttgcagcta  tctgggcat  cacacgctc  tgagcaacc  480
gcagtacta  caagccttg  gcagcagct  catcgtgaa  aaggagggg  tcaacagtg  540
gatcaaacc  acacagtac  agcctgtgc  tgatgaaga  ccaaatcca  cagatgtag  600
ggaaacgct  gagcgaata  agaacaatg  cccagaact  gaagaggtt  atcttaaca  660
catccggaa  attcccata  ccactctca  ggcgtacgc  gaaagcctg  aagagaact  720
ctacgtgaa  aagttcagc  tcgtgggga  ccgcagcaa  gaccctgtg  catttgctc  780
tgctgaaat  ctgaaggtg  acaaggtgt  gaagacgct  aatgtcgag  ccaacttca  840
ctccggagc  gggatcctg  gcctggtgg  agctctccc  cacaacact  ctctggtcg  900
actgaaaat  gacaaccag  gccagcctt  gggcaacaa  gtggaaatg  agatcgtga  960
catgttgga  aaaaacaca  cactcctca  atttggcta  cactttacc  agcaggggc  1020
ccggctgcg  gcatccaac  ccatgatga  caacaacga  cttgtgagg  agaggaggc  1080
cgcagacct  acggggcct  ttattccca  gtgccgcag  ggtgtctag  gcgcaaagg  1140
acgcccacg  ctataagct  gacgtgttc  accgatggt  tgtgttccc  agtggagac  1200
aggaggcaa  tgttggcgt  aactcttgt  gttcagttc  ttgtgcact  aggtttagg  1260
taactagtg  ctgtagttg  accttttat  aaatatggt  aatgtgaag  ttttcttta  1320
tcacagaag  tcagtctga  aattattta  aaa  1353



<210> 8715
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> AAC52855
<400> 8715

Met Ser Tyr Arg Arg Glu Leu Glu Lys Tyr Arg Asp Leu Asp Glu Asp 
  1               5                  10                  15
Glu Ile Leu Gly Ala Leu Thr Glu Glu Glu Leu Arg Thr Leu Glu Asn 
             20                  25                  30
Glu Leu Asp Glu Leu Asp Pro Asp Asn Ala Leu Leu Pro Ala Gly Leu 
         35                  40                  45
Arg Gln Lys Asp Gln Thr Thr Lys Ala Pro Thr Gly Pro Phe Lys Arg 
     50                  55                  60
Glu Glu Leu Leu Asp His Leu Glu Lys Gln Ala Lys Glu Phe Lys Asp 
 65                  70                  75                  80
Arg Glu Asp Leu Val Pro Tyr Thr Gly Glu Lys Arg Gly Lys Ile Trp 
                 85                  90                  95
Val Pro Lys Gln Lys Pro Met Asp Pro Val Leu Glu Ser Val Thr Leu 
             100                105                110
Glu Pro Glu Leu Glu Glu Ala Leu Ala Asn Ala Ser Asp Ala Glu Leu 
         115                120                125
Cys Asp Ile Ala Ala Ile Leu Gly Met His Thr Leu Met Ser Asn Gln 
     130                135                140
Gln Tyr Tyr Gln Ala Leu Gly Ser Ser Ser Ile Val Asn Lys Glu Gly 
 145                150                155                160
Leu Asn Ser Val Ile Lys Pro Thr Gln Tyr Lys Pro Val Pro Asp Glu 
                 165                170                175
Glu Pro Asn Pro Thr Asp Val Glu Glu Thr Leu Glu Arg Ile Lys Asn 
             180                185                190
Asn Asp Pro Glu Leu Glu Glu Val Asn Leu Asn Asn Ile Arg Asn Ile 
         195                200                205
Pro Ile Pro Thr Leu Lys Ala Tyr Ala Glu Ser Leu Lys Glu Asn Ser 
     210                215                220
Tyr Val Lys Lys Phe Ser Ile Val Gly Thr Arg Ser Asn Asp Pro Val 
 225                230                235                240
Ala Phe Ala Leu Ala Glu Met Leu Lys Val Asn Lys Val Leu Lys Thr 
                 245                250                255
Leu Asn Val Glu Ser Asn Phe Ile Ser Gly Ala Gly Ile Leu Cys Leu 
             260                265                270
Val Glu Ala Leu Pro His Asn Thr Ser Leu Val Glu Leu Lys Ile Asp 
         275                280                285
Asn Gln Ser Gln Pro Leu Gly Asn Lys Val Glu Met Glu Ile Val Asn 
     290                295                300
Met Leu Glu Lys Asn Thr Thr Leu Leu Lys Phe Gly Tyr His Phe Thr 
 305                310                315                320
Gln Gln Gly Pro Arg Leu Arg Ala Ser Asn Ala Met Met Asn Asn Asn 
                 325                330                335
Asp Leu Val Arg Lys Arg Arg Leu Ala Asp Leu Thr Gly Pro Ile Ile 
             340                345                350
Pro Lys Cys Arg Ser Gly Val 
         355



<210> 8716
<211> 2665
<212> DNA
<213> Homo sapiens
<308> M77016
<400> 8716

agaaattca  gagacacag  caagttctt  cacgatgtc  tacagacga  aactagaga  60
ataccgtga  ctggatgaa  atgaaatcc  tggagccct  acagaggaa  agctgagga  120
cctggaaaa  gagctggat  agctggacc  tgataatgc  ctgctgcct  caggcctga  180
gcagaagga  cagaccacc  aggcgccca  gggcccctt  aaaagagag  agctcttgg  240
tcacttgga  aagcaagca  aggagttta  ggaccgaga  gatctggtc  cctacacag  300
ggaaaaacg  ggaaaggtc  gggttccta  gcagaagcc  ctggatcct  tgctggaaa  360
tgtgacgct  gaaccggag  tggaggaag  cttggcaaa  gcttcagat  cagaactct  420
tgacattgc  gcgatcctg  gcatgcaca  gctcatgag  aaccagcag  actaccagg  480
cctgagcag  agctccatc  tgaacaagg  ggggctcaa  agcgtgatt  aacccacac  540
atacaagcc  gtgcccgac  aagaaccaa  ttcaacaga  gtagaggaa  cgctggaac  600
gataaagaa  aacgaccca  aacttgaag  agttaacct  aataatatc  ggaatatcc  660
catccccac  ctcaaggca  atgcagaag  cctgaaaga  aactcatat  tgaagaagt  720
cagcatcgt  gggacacgg  gtaatgacc  cgtggcgta  gcccttgct  agatgctca  780
ggagaacaa  gtgttgaag  cactgaatg  ggaatccaa  ttcatttct  gagctggga  840
tctgcgcct  gtagaagcc  tcccataca  cacttctct  gtggaaatg  aaattgaca  900
ccagagcca  cccctgggc  acaaagtgg  aatggagat  gtgagcatg  tggaaaaaa  960
cgcaacact  ctcaaattc  gctaccact  tacccagca  ggaccccgg  ttcgggcat  1020
caacgcaat  atgaacaac  atgaccttg  gaggaagag  aggcttgcg  acctgactg  1080
gcccatcat  cccaagtgc  ggagtggtg  ctagtgtgt  gcggtggag  ccatgcctt  1140
gaactggat  tgttctatt  atgacctgt  ctctgcagg  gaaaccaga  ggcaaaatg  1200
tggcagcat  aaacccttt  gtggttcag  tctttatgc  ctaaggttt  aggttgact  1260
gtggttgta  ttgaaaatt  tataaaata  cgttaatgt  aagtttttc  ttagtcaca  1320
aagttgaat  tggttatta  ttaaaaact  gaagccccc  aaccagcag  tcttactga  1380
gatgatgtt  cagcagcag  gacttagcc  caggagccc  gtttcaatg  ccttgctgt  1440
tggtgtttc  agtgcattt  aaatgtgtg  cacagaaac  gcacactct  ccacatgct  1500
ttgaagtat  ataaaacac  ttattacaa  tttgtctta  ctattagca  ataaaactg  1560
ttatcattc  ttattaacc  tccttggaa  tttgaaaac  tcgattaaa  ttgccaaat  1620
gattactgg  tccagaaca  aattttccc  tcagaacag  tagacagac  gaagccact  1680
aactctgcc  ggagtcaac  tgagattcc  tttgctgga  atgcagaaa  gataggaaa  1740
aaaccaatg  tgaaatttc  agtttcaaa  accaacctt  cattaccaa  cccaggcaa  1800
aaacatgtc  ctgagtgtt  tttaagaac  tttgggatt  atgtacaat  taatactgg  1860
gttagaact  tttccttat  gaatgccaa  cttatgatg  atgtgaaaa  ctacggcca  1920
atacttttg  aaacacctt  ctatattgc  cagtgggca  atggcttat  tgaggtaag  1980
cactagagg  ataaatttc  agatcaaca  ggctatggt  tttagtaat  gcccagctt  2040
gagacttca  ctactgatc  catcactta  tagacaaat  gctgctgac  ttacgcctg  2100
atattaagc  tccgcagga  gccggacaa  ggtgaagaa  ctccagata  caaggaatt  2160
ggaaatcct  gccaaacca  cccaagatg  ttacactga  atgtagtat  agtactgct  2220
ccagatctc  ttttaacat  atgtgcgtc  cttgggatc  agcaaaagt  ttaagccac  2280
atgcccttg  gccttttaa  ataccacag  gccagttaa  ctaatattt  tgtttgttg  2340
ttttgggag  tattttcat  agtgatttc  gcaaatctc  tgataaagg  caaggtcaa  2400
aactccaga  cactgagca  agaggctgg  gatgaaaag  tgaaggcct  cgcactgaa  2460
tgtaaggca  tgggcagta  agggtaact  gaggcgggg  cagggcctc  gcgctatgg  2520
agagtgtcc  ctgaggctg  acatggccc  ggagtggca  catgttgca  ggacaacca  2580
ccccatttg  cttctcctt  aaacacaat  gcagctgca  tctgcatcg  tgaaaactg  2640
aatataata  taaatctgt  ggtcg  2665



<210> 8717
<211> 359
<212> PRT
<213> Homo sapiens
<308> P28289
<400> 8717

Met Ser Tyr Arg Arg Glu Leu Glu Lys Tyr Arg Asp Leu Asp Glu Asp 
  1               5                  10                  15
Glu Ile Leu Gly Ala Leu Thr Glu Glu Glu Leu Arg Thr Leu Glu Asn 
             20                  25                  30
Glu Leu Asp Glu Leu Asp Pro Asp Asn Ala Leu Leu Pro Ala Gly Leu 
         35                  40                  45
Arg Gln Lys Asp Gln Thr Thr Lys Ala Pro Thr Gly Pro Phe Lys Arg 
     50                  55                  60
Glu Glu Leu Leu Asp His Leu Glu Lys Gln Ala Lys Glu Phe Lys Asp 
 65                  70                  75                  80
Arg Glu Asp Leu Val Pro Tyr Thr Gly Glu Lys Arg Gly Lys Val Trp 
                 85                  90                  95
Val Pro Lys Gln Lys Pro Leu Asp Pro Val Leu Glu Ser Val Thr Leu 
             100                105                110
Glu Pro Glu Leu Glu Glu Ala Leu Ala Asn Ala Ser Asp Ala Glu Leu 
         115                120                125
Cys Asp Ile Ala Ala Ile Leu Gly Met His Thr Leu Met Ser Asn Gln 
     130                135                140
Gln Tyr Tyr Gln Ala Leu Ser Ser Ser Ser Ile Met Asn Lys Glu Gly 
 145                150                155                160
Leu Asn Ser Val Ile Lys Pro Thr Gln Tyr Lys Pro Val Pro Asp Glu 
                 165                170                175
Glu Pro Asn Ser Thr Asp Val Glu Glu Thr Leu Glu Arg Ile Lys Asn 
             180                185                190
Asn Asp Pro Lys Leu Glu Glu Val Asn Leu Asn Asn Ile Arg Asn Ile 
         195                200                205
Pro Ile Pro Thr Leu Lys Ala Tyr Ala Glu Ala Leu Lys Glu Asn Ser 
     210                215                220
Tyr Val Lys Lys Phe Ser Ile Val Gly Thr Arg Ser Asn Asp Pro Val 
 225                230                235                240
Ala Tyr Ala Leu Ala Glu Met Leu Lys Glu Asn Lys Val Leu Lys Thr 
                 245                250                255
Leu Asn Val Glu Ser Asn Phe Ile Ser Gly Ala Gly Ile Leu Arg Leu 
             260                265                270
Val Glu Ala Leu Pro Tyr Asn Thr Ser Leu Val Glu Met Lys Ile Asp 
         275                280                285
Asn Gln Ser Gln Pro Leu Gly Asn Lys Val Glu Met Glu Ile Val Ser 
     290                295                300
Met Leu Glu Lys Asn Ala Thr Leu Leu Lys Phe Gly Tyr His Phe Thr 
 305                310                315                320
Gln Gln Gly Pro Arg Leu Arg Ala Ser Asn Ala Met Met Asn Asn Asn 
                 325                330                335
Asp Leu Val Arg Lys Arg Arg Leu Ala Asp Leu Thr Gly Pro Ile Ile 
             340                345                350
Pro Lys Cys Arg Ser Gly Val 
         355



<210> 8718
<211> 1353
<212> DNA
<213> Rattus norvegicus
<308> U59241
<400> 8718

ccccgcatc  cggtcacca  ttcaggaga  aaagacaca  cctcccaca  tgtcctaca  60
acgagagct  gagaaatat  gagacctgg  tgaggatga  atcctgggg  ccctcacag  120
ggaggagct  aggacactg  aaaacgagc  ggatgagct  gaccctgat  atgcactgc  180
ccctgcagg  ctgaggcag  aggatcaga  caccaaggc  cccacaggc  cctttaaaa  240
agaggagct  ttggaccac  tggaaaagc  agcgaagga  tttaaggac  gagaagacc  300
ggttcccta  acaggggag  aacgaggaa  gatctgggt  cccaagcag  agccaatgg  360
tcccgtgct  gagagcgtg  cgctggagc  ggaactgga  gaggcccta  caaatgcct  420
agatgccga  ctatgtgac  ttgcagcta  tctgggcat  cacacgctc  tgagcaacc  480
gcagtacta  caagccttg  gcagcagct  catcgtgaa  aaggagggg  tcaacagtg  540
gatcaaacc  acacagtac  agcctgtgc  tgatgaaga  ccaaatcca  cagatgtag  600
ggaaacgct  gagcgaata  agaacaatg  cccagaact  gaagaggtt  atcttaaca  660
catccggaa  attcccata  ccactctca  ggcgtacgc  gaaagcctg  aagagaact  720
ctacgtgaa  aagttcagc  tcgtgggga  ccgcagcaa  gaccctgtg  catttgctc  780
tgctgaaat  ctgaaggtg  acaaggtgt  gaagacgct  aatgtcgag  ccaacttca  840
ctccggagc  gggatcctg  gcctggtgg  agctctccc  cacaacact  ctctggtcg  900
actgaaaat  gacaaccag  gccagcctt  gggcaacaa  gtggaaatg  agatcgtga  960
catgttgga  aaaaacaca  cactcctca  atttggcta  cactttacc  agcaggggc  1020
ccggctgcg  gcatccaac  ccatgatga  caacaacga  cttgtgagg  agaggaggc  1080
cgcagacct  acggggcct  ttattccca  gtgccgcag  ggtgtctag  gcgcaaagg  1140
acgcccacg  ctataagct  gacgtgttc  accgatggt  tgtgttccc  agtggagac  1200
aggaggcaa  tgttggcgt  aactcttgt  gttcagttc  ttgtgcact  aggtttagg  1260
taactagtg  ctgtagttg  accttttat  aaatatggt  aatgtgaag  ttttcttta  1320
tcacagaag  tcagtctga  aattattta  aaa  1353



<210> 8719
<211> 359
<212> PRT
<213> Rattus norvegicus
<308> AAC52855
<400> 8719

Met Ser Tyr Arg Arg Glu Leu Glu Lys Tyr Arg Asp Leu Asp Glu Asp 
  1               5                  10                  15
Glu Ile Leu Gly Ala Leu Thr Glu Glu Glu Leu Arg Thr Leu Glu Asn 
             20                  25                  30
Glu Leu Asp Glu Leu Asp Pro Asp Asn Ala Leu Leu Pro Ala Gly Leu 
         35                  40                  45
Arg Gln Lys Asp Gln Thr Thr Lys Ala Pro Thr Gly Pro Phe Lys Arg 
     50                  55                  60
Glu Glu Leu Leu Asp His Leu Glu Lys Gln Ala Lys Glu Phe Lys Asp 
 65                  70                  75                  80
Arg Glu Asp Leu Val Pro Tyr Thr Gly Glu Lys Arg Gly Lys Ile Trp 
                 85                  90                  95
Val Pro Lys Gln Lys Pro Met Asp Pro Val Leu Glu Ser Val Thr Leu 
             100                105                110
Glu Pro Glu Leu Glu Glu Ala Leu Ala Asn Ala Ser Asp Ala Glu Leu 
         115                120                125
Cys Asp Ile Ala Ala Ile Leu Gly Met His Thr Leu Met Ser Asn Gln 
     130                135                140
Gln Tyr Tyr Gln Ala Leu Gly Ser Ser Ser Ile Val Asn Lys Glu Gly 
 145                150                155                160
Leu Asn Ser Val Ile Lys Pro Thr Gln Tyr Lys Pro Val Pro Asp Glu 
                 165                170                175
Glu Pro Asn Pro Thr Asp Val Glu Glu Thr Leu Glu Arg Ile Lys Asn 
             180                185                190
Asn Asp Pro Glu Leu Glu Glu Val Asn Leu Asn Asn Ile Arg Asn Ile 
         195                200                205
Pro Ile Pro Thr Leu Lys Ala Tyr Ala Glu Ser Leu Lys Glu Asn Ser 
     210                215                220
Tyr Val Lys Lys Phe Ser Ile Val Gly Thr Arg Ser Asn Asp Pro Val 
 225                230                235                240
Ala Phe Ala Leu Ala Glu Met Leu Lys Val Asn Lys Val Leu Lys Thr 
                 245                250                255
Leu Asn Val Glu Ser Asn Phe Ile Ser Gly Ala Gly Ile Leu Cys Leu 
             260                265                270
Val Glu Ala Leu Pro His Asn Thr Ser Leu Val Glu Leu Lys Ile Asp 
         275                280                285
Asn Gln Ser Gln Pro Leu Gly Asn Lys Val Glu Met Glu Ile Val Asn 
     290                295                300
Met Leu Glu Lys Asn Thr Thr Leu Leu Lys Phe Gly Tyr His Phe Thr 
 305                310                315                320
Gln Gln Gly Pro Arg Leu Arg Ala Ser Asn Ala Met Met Asn Asn Asn 
                 325                330                335
Asp Leu Val Arg Lys Arg Arg Leu Ala Asp Leu Thr Gly Pro Ile Ile 
             340                345                350
Pro Lys Cys Arg Ser Gly Val 
         355



<210> 8720
<211> 2665
<212> DNA
<213> Homo sapiens
<308> M77016
<400> 8720

agaaattca  gagacacag  caagttctt  cacgatgtc  tacagacga  aactagaga  60
ataccgtga  ctggatgaa  atgaaatcc  tggagccct  acagaggaa  agctgagga  120
cctggaaaa  gagctggat  agctggacc  tgataatgc  ctgctgcct  caggcctga  180
gcagaagga  cagaccacc  aggcgccca  gggcccctt  aaaagagag  agctcttgg  240
tcacttgga  aagcaagca  aggagttta  ggaccgaga  gatctggtc  cctacacag  300
ggaaaaacg  ggaaaggtc  gggttccta  gcagaagcc  ctggatcct  tgctggaaa  360
tgtgacgct  gaaccggag  tggaggaag  cttggcaaa  gcttcagat  cagaactct  420
tgacattgc  gcgatcctg  gcatgcaca  gctcatgag  aaccagcag  actaccagg  480
cctgagcag  agctccatc  tgaacaagg  ggggctcaa  agcgtgatt  aacccacac  540
atacaagcc  gtgcccgac  aagaaccaa  ttcaacaga  gtagaggaa  cgctggaac  600
gataaagaa  aacgaccca  aacttgaag  agttaacct  aataatatc  ggaatatcc  660
catccccac  ctcaaggca  atgcagaag  cctgaaaga  aactcatat  tgaagaagt  720
cagcatcgt  gggacacgg  gtaatgacc  cgtggcgta  gcccttgct  agatgctca  780
ggagaacaa  gtgttgaag  cactgaatg  ggaatccaa  ttcatttct  gagctggga  840
tctgcgcct  gtagaagcc  tcccataca  cacttctct  gtggaaatg  aaattgaca  900
ccagagcca  cccctgggc  acaaagtgg  aatggagat  gtgagcatg  tggaaaaaa  960
cgcaacact  ctcaaattc  gctaccact  tacccagca  ggaccccgg  ttcgggcat  1020
caacgcaat  atgaacaac  atgaccttg  gaggaagag  aggcttgcg  acctgactg  1080
gcccatcat  cccaagtgc  ggagtggtg  ctagtgtgt  gcggtggag  ccatgcctt  1140
gaactggat  tgttctatt  atgacctgt  ctctgcagg  gaaaccaga  ggcaaaatg  1200
tggcagcat  aaacccttt  gtggttcag  tctttatgc  ctaaggttt  aggttgact  1260
gtggttgta  ttgaaaatt  tataaaata  cgttaatgt  aagtttttc  ttagtcaca  1320
aagttgaat  tggttatta  ttaaaaact  gaagccccc  aaccagcag  tcttactga  1380
gatgatgtt  cagcagcag  gacttagcc  caggagccc  gtttcaatg  ccttgctgt  1440
tggtgtttc  agtgcattt  aaatgtgtg  cacagaaac  gcacactct  ccacatgct  1500
ttgaagtat  ataaaacac  ttattacaa  tttgtctta  ctattagca  ataaaactg  1560
ttatcattc  ttattaacc  tccttggaa  tttgaaaac  tcgattaaa  ttgccaaat  1620
gattactgg  tccagaaca  aattttccc  tcagaacag  tagacagac  gaagccact  1680
aactctgcc  ggagtcaac  tgagattcc  tttgctgga  atgcagaaa  gataggaaa  1740
aaaccaatg  tgaaatttc  agtttcaaa  accaacctt  cattaccaa  cccaggcaa  1800
aaacatgtc  ctgagtgtt  tttaagaac  tttgggatt  atgtacaat  taatactgg  1860
gttagaact  tttccttat  gaatgccaa  cttatgatg  atgtgaaaa  ctacggcca  1920
atacttttg  aaacacctt  ctatattgc  cagtgggca  atggcttat  tgaggtaag  1980
cactagagg  ataaatttc  agatcaaca  ggctatggt  tttagtaat  gcccagctt  2040
gagacttca  ctactgatc  catcactta  tagacaaat  gctgctgac  ttacgcctg  2100
atattaagc  tccgcagga  gccggacaa  ggtgaagaa  ctccagata  caaggaatt  2160
ggaaatcct  gccaaacca  cccaagatg  ttacactga  atgtagtat  agtactgct  2220
ccagatctc  ttttaacat  atgtgcgtc  cttgggatc  agcaaaagt  ttaagccac  2280
atgcccttg  gccttttaa  ataccacag  gccagttaa  ctaatattt  tgtttgttg  2340
ttttgggag  tattttcat  agtgatttc  gcaaatctc  tgataaagg  caaggtcaa  2400
aactccaga  cactgagca  agaggctgg  gatgaaaag  tgaaggcct  cgcactgaa  2460
tgtaaggca  tgggcagta  agggtaact  gaggcgggg  cagggcctc  gcgctatgg  2520
agagtgtcc  ctgaggctg  acatggccc  ggagtggca  catgttgca  ggacaacca  2580
ccccatttg  cttctcctt  aaacacaat  gcagctgca  tctgcatcg  tgaaaactg  2640
aatataata  taaatctgt  ggtcg  2665



<210> 8721
<211> 359
<212> PRT
<213> Homo sapiens
<308> P28289
<400> 8721

Met Ser Tyr Arg Arg Glu Leu Glu Lys Tyr Arg Asp Leu Asp Glu Asp 
  1               5                  10                  15
Glu Ile Leu Gly Ala Leu Thr Glu Glu Glu Leu Arg Thr Leu Glu Asn 
             20                  25                  30
Glu Leu Asp Glu Leu Asp Pro Asp Asn Ala Leu Leu Pro Ala Gly Leu 
         35                  40                  45
Arg Gln Lys Asp Gln Thr Thr Lys Ala Pro Thr Gly Pro Phe Lys Arg 
     50                  55                  60
Glu Glu Leu Leu Asp His Leu Glu Lys Gln Ala Lys Glu Phe Lys Asp 
 65                  70                  75                  80
Arg Glu Asp Leu Val Pro Tyr Thr Gly Glu Lys Arg Gly Lys Val Trp 
                 85                  90                  95
Val Pro Lys Gln Lys Pro Leu Asp Pro Val Leu Glu Ser Val Thr Leu 
             100                105                110
Glu Pro Glu Leu Glu Glu Ala Leu Ala Asn Ala Ser Asp Ala Glu Leu 
         115                120                125
Cys Asp Ile Ala Ala Ile Leu Gly Met His Thr Leu Met Ser Asn Gln 
     130                135                140
Gln Tyr Tyr Gln Ala Leu Ser Ser Ser Ser Ile Met Asn Lys Glu Gly 
 145                150                155                160
Leu Asn Ser Val Ile Lys Pro Thr Gln Tyr Lys Pro Val Pro Asp Glu 
                 165                170                175
Glu Pro Asn Ser Thr Asp Val Glu Glu Thr Leu Glu Arg Ile Lys Asn 
             180                185                190
Asn Asp Pro Lys Leu Glu Glu Val Asn Leu Asn Asn Ile Arg Asn Ile 
         195                200                205
Pro Ile Pro Thr Leu Lys Ala Tyr Ala Glu Ala Leu Lys Glu Asn Ser 
     210                215                220
Tyr Val Lys Lys Phe Ser Ile Val Gly Thr Arg Ser Asn Asp Pro Val 
 225                230                235                240
Ala Tyr Ala Leu Ala Glu Met Leu Lys Glu Asn Lys Val Leu Lys Thr 
                 245                250                255
Leu Asn Val Glu Ser Asn Phe Ile Ser Gly Ala Gly Ile Leu Arg Leu 
             260                265                270
Val Glu Ala Leu Pro Tyr Asn Thr Ser Leu Val Glu Met Lys Ile Asp 
         275                280                285
Asn Gln Ser Gln Pro Leu Gly Asn Lys Val Glu Met Glu Ile Val Ser 
     290                295                300
Met Leu Glu Lys Asn Ala Thr Leu Leu Lys Phe Gly Tyr His Phe Thr 
 305                310                315                320
Gln Gln Gly Pro Arg Leu Arg Ala Ser Asn Ala Met Met Asn Asn Asn 
                 325                330                335
Asp Leu Val Arg Lys Arg Arg Leu Ala Asp Leu Thr Gly Pro Ile Ile 
             340                345                350
Pro Lys Cys Arg Ser Gly Val 
         355



<210> 8722
<211> 2230
<212> DNA
<213> Rattus norvegicus
<308> U59672
<400> 8722

gaattcggg  agaccctcg  tctccaaag  tacatagac  cttggattc  agagggcac  60
agaaaaggg  gtcttggtg  tcctcccag  acaccccag  aagccagga  acccctggc  120
gcaccactc  ttcagggtc  gccttagtg  cctgtccaa  agcactgct  tgaccacag  180
gctgcaggt  ccaggacaa  aggcctagt  gctctcaga  agccagtac  gtcctaggc  240
cagagctga  tcgactctg  aactggggc  aggaagggt  aggatggac  gtggggatg  300
aagggggag  tccccaaat  tccagggca  aagaacagc  agtctccat  gagagagcc  360
cactgttcc  ttccgtgct  atagcccag  gagaaggca  ccggaggag  gccacccag  420
cccacagca  cacccagcc  gctctgctg  ggctgtcag  tcacctcct  gctaactac  480
agaagggag  gcggcctgt  cgggactgg  ggaagccca  cctggtctc  attgatgtc  540
tcatgtatg  catcctcaa  gtggatgag  agaaccagg  tctgaccac  tacatatgg  600
accggcagt  ctggaccga  gagtttcta  agtggactc  tgaggactt  gacaatgtc  660
ccaaattgt  catccccac  gacagcatc  gggtccctg  catcctcat  aatgagttt  720
tggacgtgg  gaagtctcc  agcattcct  atgtgtatg  gcaccatca  ggtgaagtc  780
agaactaca  gcccctaca  ctggtgacc  cctgtagcc  tgacatcta  aacttcccg  840
tcgatgtgc  gaactgctc  ctgaccttc  ccagctggc  gcataccat  caggacatc  900
acatttccc  gtggcgaac  ccagaagaa  tgaggtcgg  caagagcat  ttcataaat  960
agggcgagt  ggagctgct  ggggtgttc  ccaaatttc  ggagttcag  atagaaacc  1020
gtaacagct  tgcggaaat  aagttctac  tggtcatcc  ccggcggcc  ttattctac  1080
cagtcagcc  cttgctgcc  agtatcttc  tcatggtcg  ggacattgt  ggcttttgt  1140
tgcccccgg  cagtggtga  agagtgtct  tcaagatca  gctccttct  ggatactca  1200
tctttctca  catcgtgtc  gacacactg  ctgcaacgg  catcggcac  cccctcatt  1260
gtgtctact  tgtagtgtg  atggctctg  tggtgataa  cctcgctga  accatcttc  1320
ttgtgcagc  ggtgcataa  caggattta  agcgccctg  acctgactg  ctgaggcac  1380
tggtcctag  cagaatagc  tggctgctc  gcctagggg  gcagcccat  gcccatagg  1440
ccccagcca  cttccaagc  aacaagact  atgactgct  agccatggg  aaccactgc  1500
gccatgtcg  aagccctca  gacttggag  agacctcga  gagcagaga  agccctctt  1560
caccaccaa  ggaggcctc  ctggctgtg  gtggcctct  gcaagagct  tcctccatc  1620
gccactccc  ggagaagcg  gatgagatg  gggaggtgg  aagggactg  ttgcgggtg  1680
gatatgtgc  ggacaggct  ctgtttcgc  tctacctgc  ggccgtgct  gcttacagc  1740
tcaccctgg  cacgctctg  tccatttgg  attattcct  agtgggtac  gcctggcag  1800
gaggggatg  gagtcctgc  tcctgtttc  aacaccaat  catctgagc  accccagtc  1860
ccttgtccc  taaacttag  actgaagac  cggtcagac  ccccgactt  gctatcatg  1920
ctttaaagc  tgatatcct  gatcaagag  aaccaagac  cctctaact  attaagaca  1980
caagccctg  ttccttttc  agtacttct  tgattatgg  ccttgggat  gctcatttc  2040
acagttttt  tttcctttt  gatcagagg  aagcaaatt  tcttgccta  gtgcctgag  2100
cgtctgtgc  tgttttatc  aggccccag  ggcttcttc  tcagctcac  tgtgggtac  2160
tccctagcg  tcagcctca  caaccaacg  ggggagggg  taataaaat  ctatgatat  2220
ccccgaattc  2230



<210> 8723
<211> 227
<212> PRT
<213> Rattus norvegicus
<308> AAB18293
<400> 8723

Pro Ser Ile Phe Leu Met Val Val Asp Ile Gly Gly Phe Cys Leu Pro 
  1               5                  10                  15
Pro Asp Ser Gly Glu Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly 
             20                  25                  30
Tyr Ser Val Phe Leu Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala 
         35                  40                  45
Ile Gly Thr Pro Leu Ile Gly Val Tyr Phe Val Val Cys Met Ala Leu 
     50                  55                  60
Leu Val Ile Ser Leu Ala Glu Thr Ile Phe Ile Val Gln Leu Val His 
 65                  70                  75                  80
Lys Gln Asp Leu Gln Arg Pro Val Pro Asp Trp Leu Arg His Leu Val 
                 85                  90                  95
Leu Asp Arg Ile Ala Trp Leu Leu Cys Leu Gly Glu Gln Pro Met Ala 
             100                105                110
His Arg Pro Pro Ala Thr Phe Gln Ala Asn Lys Thr Asp Asp Cys Ser 
         115                120                125
Ala Met Gly Asn His Cys Ser His Val Gly Ser Pro Gln Asp Leu Glu 
     130                135                140
Lys Thr Ser Arg Ser Arg Asp Ser Pro Leu Pro Pro Pro Arg Glu Ala 
 145                150                155                160
Ser Leu Ala Val Arg Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg His 
                 165                170                175
Ser Leu Glu Lys Arg Asp Glu Met Arg Glu Val Ala Arg Asp Trp Leu 
             180                185                190
Arg Val Gly Tyr Val Leu Asp Arg Leu Leu Phe Arg Ile Tyr Leu Leu 
         195                200                205
Ala Val Leu Ala Tyr Ser Ile Thr Leu Val Thr Leu Trp Ser Ile Trp 
     210                215                220
His Tyr Ser 
 225



<210> 8724
<211> 1642
<212> DNA
<213> Homo sapiens
<308> AJ003078
<400> 8724

ctgagcact  ggaggcact  ctatgcttg  aaagctcgc  atgctgctg  gggtccagc  60
ggcgctgct  gccttgctc  tccccacac  cctggcaca  ggagaagcc  ggaggagcc  120
aaacaccac  aggcccgct  tgctgaggc  gtcggatta  cttttgacc  actacagga  180
gggtgtgcg  cccgtgagg  actggagga  gccaaccac  gtatccatt  acgtcattg  240
ctatgccat  ctcaacgtg  atgagaaga  tcaggtgct  accacctac  tctggtacc  300
gcagtactg  actgatgag  ttctccagt  gaaccctga  gactttgac  acatcacca  360
gttgtccat  cccacggac  gcatctggg  cccggacat  ctcatcaat  agttcgtgg  420
tgtggggaa  tctccaaat  tcccgtacg  gtatattcg  catcaaggc  aagttcaga  480
ctacaagcc  cttcaggtg  tgactgcct  tagcctcga  atctacaac  tccccttcg  540
tgtccagaa  tgctcgctg  ccttcacca  ttggctgca  accatccag  acatcaaca  600
ctctttgtg  cgcttgcca  aaaaggtga  atccgacag  agtgtcttc  tgaaccagg  660
agagtggga  ttgctgggg  tgctgccct  ctttcggga  ttcagcatg  aaagcagta  720
ctactatgc  gaaatgaag  tctatgtgg  catccgccg  cggcccctc  tctatgtgg  780
cagcctgct  ctgcccagc  tcttcctca  ggtcatgga  atcgtgggc  tctacctgc  840
ccccaacag  ggcgagagg  tctctttca  aattacact  ctcctgggc  actcggtct  900
cctgatcat  gtttctgac  cgctgccgg  cactgccat  ggcactcct  tcattggta  960
ggcccctcc  ggcagcaga  ctcagtctg  tgagaaacc  gccccctcc  acctcctgc  1020
tgtgtctct  gcctctgcc  tgggctgca  aggtgtcta  tttgtggtg  gcatggctc  1080
gctggtgat  agtttggcc  agaccatct  cattgtgcg  ctggtgcac  agcaagacc  1140
gcagcagcc  gtgcctgct  ggctgcgtc  cctggttct  gagagaatc  cctggctac  1200
ttgcctgag  gagcagtca  cttcccaga  gcccccagc  acctcccaa  ccaccaaga  1260
tgatgactg  tcagccatg  gaaaccact  cagccacat  ggaggaccc  aggacttcg  1320
gaagagccc  agggacaga  gtagccctc  cccaccacc  cgggaggcc  cgctggcgg  1380
gtgtgggct  ctgcaggag  tgtcctcca  ccggcaatt  ctggaaaag  gggatgaga  1440
ccgagaggt  gcccgagac  ggctgcgcg  gggctccgt  ctggacaag  tgctattcc  1500
catttacct  ctagcggtg  tggcctaca  catcaccct  gttatgctc  ggtccatct  1560
gcagtacgc  tgagtgggt  cagcccagt  gaggagggg  tacagtcct  gttaggtgg  1620
gacagagga  ttctgctta  gc  1642



<210> 8725
<211> 478
<212> PRT
<213> Homo sapiens
<308> P46098
<400> 8725

Met Leu Leu Trp Val Gln Gln Ala Leu Leu Ala Leu Leu Leu Pro Thr 
  1               5                  10                  15
Leu Leu Ala Gln Gly Glu Ala Arg Arg Ser Arg Asn Thr Thr Arg Pro 
             20                  25                  30
Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu Thr Asn Tyr Arg Lys Gly 
         35                  40                  45
Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr Thr Val Ser Ile Asp 
     50                  55                  60
Val Ile Val Tyr Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val Leu 
 65                  70                  75                  80
Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp Thr Asp Glu Phe Leu Gln 
                 85                  90                  95
Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr Lys Leu Ser Ile Pro Thr 
             100                105                110
Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn Glu Phe Val Asp Val 
         115                120                125
Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr Ile Arg His Gln Gly Glu 
     130                135                140
Val Gln Asn Tyr Lys Pro Leu Gln Val Val Thr Ala Cys Ser Leu Asp 
 145                150                155                160
Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Thr 
                 165                170                175
Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile Ser Leu Trp Arg Leu 
             180                185                190
Pro Glu Lys Val Lys Ser Asp Arg Ser Val Phe Met Asn Gln Gly Glu 
         195                200                205
Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe Arg Glu Phe Ser Met Glu 
     210                215                220
Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe Tyr Val Val Ile Arg Arg 
 225                230                235                240
Arg Pro Leu Phe Tyr Val Val Ser Leu Leu Leu Pro Ser Ile Phe Leu 
                 245                250                255
Met Val Met Asp Ile Val Gly Phe Tyr Leu Pro Pro Asn Ser Gly Glu 
             260                265                270
Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly Tyr Ser Val Phe Leu 
         275                280                285
Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala Ile Gly Thr Pro Leu 
     290                295                300
Ile Gly Val Tyr Phe Val Val Cys Met Ala Leu Leu Val Ile Ser Leu 
 305                310                315                320
Ala Glu Thr Ile Phe Ile Val Arg Leu Val His Lys Gln Asp Leu Gln 
                 325                330                335
Gln Pro Val Pro Ala Trp Leu Arg His Leu Val Leu Glu Arg Ile Ala 
             340                345                350
Trp Leu Leu Cys Leu Arg Glu Gln Ser Thr Ser Gln Arg Pro Pro Ala 
         355                360                365
Thr Ser Gln Ala Thr Lys Thr Asp Asp Cys Ser Ala Met Gly Asn His 
     370                375                380
Cys Ser His Met Gly Gly Pro Gln Asp Phe Glu Lys Ser Pro Arg Asp 
 385                390                395                400
Arg Cys Ser Pro Pro Pro Pro Pro Arg Glu Ala Ser Leu Ala Val Cys 
                 405                410                415
Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg Gln Phe Leu Glu Lys Arg 
             420                425                430
Asp Glu Ile Arg Glu Val Ala Arg Asp Trp Leu Arg Val Gly Ser Val 
         435                440                445
Leu Asp Lys Leu Leu Phe His Ile Tyr Leu Leu Ala Val Leu Ala Tyr 
     450                455                460
Ser Ile Thr Leu Val Met Leu Trp Ser Ile Trp Gln Tyr Ala 
 465                470                475



<210> 8726
<211> 2230
<212> DNA
<213> Rattus norvegicus
<308> U59672
<400> 8726

gaattcggg  agaccctcg  tctccaaag  tacatagac  cttggattc  agagggcac  60
agaaaaggg  gtcttggtg  tcctcccag  acaccccag  aagccagga  acccctggc  120
gcaccactc  ttcagggtc  gccttagtg  cctgtccaa  agcactgct  tgaccacag  180
gctgcaggt  ccaggacaa  aggcctagt  gctctcaga  agccagtac  gtcctaggc  240
cagagctga  tcgactctg  aactggggc  aggaagggt  aggatggac  gtggggatg  300
aagggggag  tccccaaat  tccagggca  aagaacagc  agtctccat  gagagagcc  360
cactgttcc  ttccgtgct  atagcccag  gagaaggca  ccggaggag  gccacccag  420
cccacagca  cacccagcc  gctctgctg  ggctgtcag  tcacctcct  gctaactac  480
agaagggag  gcggcctgt  cgggactgg  ggaagccca  cctggtctc  attgatgtc  540
tcatgtatg  catcctcaa  gtggatgag  agaaccagg  tctgaccac  tacatatgg  600
accggcagt  ctggaccga  gagtttcta  agtggactc  tgaggactt  gacaatgtc  660
ccaaattgt  catccccac  gacagcatc  gggtccctg  catcctcat  aatgagttt  720
tggacgtgg  gaagtctcc  agcattcct  atgtgtatg  gcaccatca  ggtgaagtc  780
agaactaca  gcccctaca  ctggtgacc  cctgtagcc  tgacatcta  aacttcccg  840
tcgatgtgc  gaactgctc  ctgaccttc  ccagctggc  gcataccat  caggacatc  900
acatttccc  gtggcgaac  ccagaagaa  tgaggtcgg  caagagcat  ttcataaat  960
agggcgagt  ggagctgct  ggggtgttc  ccaaatttc  ggagttcag  atagaaacc  1020
gtaacagct  tgcggaaat  aagttctac  tggtcatcc  ccggcggcc  ttattctac  1080
cagtcagcc  cttgctgcc  agtatcttc  tcatggtcg  ggacattgt  ggcttttgt  1140
tgcccccgg  cagtggtga  agagtgtct  tcaagatca  gctccttct  ggatactca  1200
tctttctca  catcgtgtc  gacacactg  ctgcaacgg  catcggcac  cccctcatt  1260
gtgtctact  tgtagtgtg  atggctctg  tggtgataa  cctcgctga  accatcttc  1320
ttgtgcagc  ggtgcataa  caggattta  agcgccctg  acctgactg  ctgaggcac  1380
tggtcctag  cagaatagc  tggctgctc  gcctagggg  gcagcccat  gcccatagg  1440
ccccagcca  cttccaagc  aacaagact  atgactgct  agccatggg  aaccactgc  1500
gccatgtcg  aagccctca  gacttggag  agacctcga  gagcagaga  agccctctt  1560
caccaccaa  ggaggcctc  ctggctgtg  gtggcctct  gcaagagct  tcctccatc  1620
gccactccc  ggagaagcg  gatgagatg  gggaggtgg  aagggactg  ttgcgggtg  1680
gatatgtgc  ggacaggct  ctgtttcgc  tctacctgc  ggccgtgct  gcttacagc  1740
tcaccctgg  cacgctctg  tccatttgg  attattcct  agtgggtac  gcctggcag  1800
gaggggatg  gagtcctgc  tcctgtttc  aacaccaat  catctgagc  accccagtc  1860
ccttgtccc  taaacttag  actgaagac  cggtcagac  ccccgactt  gctatcatg  1920
ctttaaagc  tgatatcct  gatcaagag  aaccaagac  cctctaact  attaagaca  1980
caagccctg  ttccttttc  agtacttct  tgattatgg  ccttgggat  gctcatttc  2040
acagttttt  tttcctttt  gatcagagg  aagcaaatt  tcttgccta  gtgcctgag  2100
cgtctgtgc  tgttttatc  aggccccag  ggcttcttc  tcagctcac  tgtgggtac  2160
tccctagcg  tcagcctca  caaccaacg  ggggagggg  taataaaat  ctatgatat  2220
ccccgaattc  2230



<210> 8727
<211> 227
<212> PRT
<213> Rattus norvegicus
<308> AAB18293
<400> 8727

Pro Ser Ile Phe Leu Met Val Val Asp Ile Gly Gly Phe Cys Leu Pro 
  1               5                  10                  15
Pro Asp Ser Gly Glu Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly 
             20                  25                  30
Tyr Ser Val Phe Leu Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala 
         35                  40                  45
Ile Gly Thr Pro Leu Ile Gly Val Tyr Phe Val Val Cys Met Ala Leu 
     50                  55                  60
Leu Val Ile Ser Leu Ala Glu Thr Ile Phe Ile Val Gln Leu Val His 
 65                  70                  75                  80
Lys Gln Asp Leu Gln Arg Pro Val Pro Asp Trp Leu Arg His Leu Val 
                 85                  90                  95
Leu Asp Arg Ile Ala Trp Leu Leu Cys Leu Gly Glu Gln Pro Met Ala 
             100                105                110
His Arg Pro Pro Ala Thr Phe Gln Ala Asn Lys Thr Asp Asp Cys Ser 
         115                120                125
Ala Met Gly Asn His Cys Ser His Val Gly Ser Pro Gln Asp Leu Glu 
     130                135                140
Lys Thr Ser Arg Ser Arg Asp Ser Pro Leu Pro Pro Pro Arg Glu Ala 
 145                150                155                160
Ser Leu Ala Val Arg Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg His 
                 165                170                175
Ser Leu Glu Lys Arg Asp Glu Met Arg Glu Val Ala Arg Asp Trp Leu 
             180                185                190
Arg Val Gly Tyr Val Leu Asp Arg Leu Leu Phe Arg Ile Tyr Leu Leu 
         195                200                205
Ala Val Leu Ala Tyr Ser Ile Thr Leu Val Thr Leu Trp Ser Ile Trp 
     210                215                220
His Tyr Ser 
 225



<210> 8728
<211> 1642
<212> DNA
<213> Homo sapiens
<308> AJ003078
<400> 8728

ctgagcact  ggaggcact  ctatgcttg  aaagctcgc  atgctgctg  gggtccagc  60
ggcgctgct  gccttgctc  tccccacac  cctggcaca  ggagaagcc  ggaggagcc  120
aaacaccac  aggcccgct  tgctgaggc  gtcggatta  cttttgacc  actacagga  180
gggtgtgcg  cccgtgagg  actggagga  gccaaccac  gtatccatt  acgtcattg  240
ctatgccat  ctcaacgtg  atgagaaga  tcaggtgct  accacctac  tctggtacc  300
gcagtactg  actgatgag  ttctccagt  gaaccctga  gactttgac  acatcacca  360
gttgtccat  cccacggac  gcatctggg  cccggacat  ctcatcaat  agttcgtgg  420
tgtggggaa  tctccaaat  tcccgtacg  gtatattcg  catcaaggc  aagttcaga  480
ctacaagcc  cttcaggtg  tgactgcct  tagcctcga  atctacaac  tccccttcg  540
tgtccagaa  tgctcgctg  ccttcacca  ttggctgca  accatccag  acatcaaca  600
ctctttgtg  cgcttgcca  aaaaggtga  atccgacag  agtgtcttc  tgaaccagg  660
agagtggga  ttgctgggg  tgctgccct  ctttcggga  ttcagcatg  aaagcagta  720
ctactatgc  gaaatgaag  tctatgtgg  catccgccg  cggcccctc  tctatgtgg  780
cagcctgct  ctgcccagc  tcttcctca  ggtcatgga  atcgtgggc  tctacctgc  840
ccccaacag  ggcgagagg  tctctttca  aattacact  ctcctgggc  actcggtct  900
cctgatcat  gtttctgac  cgctgccgg  cactgccat  ggcactcct  tcattggta  960
ggcccctcc  ggcagcaga  ctcagtctg  tgagaaacc  gccccctcc  acctcctgc  1020
tgtgtctct  gcctctgcc  tgggctgca  aggtgtcta  tttgtggtg  gcatggctc  1080
gctggtgat  agtttggcc  agaccatct  cattgtgcg  ctggtgcac  agcaagacc  1140
gcagcagcc  gtgcctgct  ggctgcgtc  cctggttct  gagagaatc  cctggctac  1200
ttgcctgag  gagcagtca  cttcccaga  gcccccagc  acctcccaa  ccaccaaga  1260
tgatgactg  tcagccatg  gaaaccact  cagccacat  ggaggaccc  aggacttcg  1320
gaagagccc  agggacaga  gtagccctc  cccaccacc  cgggaggcc  cgctggcgg  1380
gtgtgggct  ctgcaggag  tgtcctcca  ccggcaatt  ctggaaaag  gggatgaga  1440
ccgagaggt  gcccgagac  ggctgcgcg  gggctccgt  ctggacaag  tgctattcc  1500
catttacct  ctagcggtg  tggcctaca  catcaccct  gttatgctc  ggtccatct  1560
gcagtacgc  tgagtgggt  cagcccagt  gaggagggg  tacagtcct  gttaggtgg  1620
gacagagga  ttctgctta  gc  1642



<210> 8729
<211> 478
<212> PRT
<213> Homo sapiens
<308> P46098
<400> 8729

Met Leu Leu Trp Val Gln Gln Ala Leu Leu Ala Leu Leu Leu Pro Thr 
  1               5                  10                  15
Leu Leu Ala Gln Gly Glu Ala Arg Arg Ser Arg Asn Thr Thr Arg Pro 
             20                  25                  30
Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu Thr Asn Tyr Arg Lys Gly 
         35                  40                  45
Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr Thr Val Ser Ile Asp 
     50                  55                  60
Val Ile Val Tyr Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val Leu 
 65                  70                  75                  80
Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp Thr Asp Glu Phe Leu Gln 
                 85                  90                  95
Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr Lys Leu Ser Ile Pro Thr 
             100                105                110
Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn Glu Phe Val Asp Val 
         115                120                125
Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr Ile Arg His Gln Gly Glu 
     130                135                140
Val Gln Asn Tyr Lys Pro Leu Gln Val Val Thr Ala Cys Ser Leu Asp 
 145                150                155                160
Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Thr 
                 165                170                175
Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile Ser Leu Trp Arg Leu 
             180                185                190
Pro Glu Lys Val Lys Ser Asp Arg Ser Val Phe Met Asn Gln Gly Glu 
         195                200                205
Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe Arg Glu Phe Ser Met Glu 
     210                215                220
Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe Tyr Val Val Ile Arg Arg 
 225                230                235                240
Arg Pro Leu Phe Tyr Val Val Ser Leu Leu Leu Pro Ser Ile Phe Leu 
                 245                250                255
Met Val Met Asp Ile Val Gly Phe Tyr Leu Pro Pro Asn Ser Gly Glu 
             260                265                270
Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly Tyr Ser Val Phe Leu 
         275                280                285
Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala Ile Gly Thr Pro Leu 
     290                295                300
Ile Gly Val Tyr Phe Val Val Cys Met Ala Leu Leu Val Ile Ser Leu 
 305                310                315                320
Ala Glu Thr Ile Phe Ile Val Arg Leu Val His Lys Gln Asp Leu Gln 
                 325                330                335
Gln Pro Val Pro Ala Trp Leu Arg His Leu Val Leu Glu Arg Ile Ala 
             340                345                350
Trp Leu Leu Cys Leu Arg Glu Gln Ser Thr Ser Gln Arg Pro Pro Ala 
         355                360                365
Thr Ser Gln Ala Thr Lys Thr Asp Asp Cys Ser Ala Met Gly Asn His 
     370                375                380
Cys Ser His Met Gly Gly Pro Gln Asp Phe Glu Lys Ser Pro Arg Asp 
 385                390                395                400
Arg Cys Ser Pro Pro Pro Pro Pro Arg Glu Ala Ser Leu Ala Val Cys 
                 405                410                415
Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg Gln Phe Leu Glu Lys Arg 
             420                425                430
Asp Glu Ile Arg Glu Val Ala Arg Asp Trp Leu Arg Val Gly Ser Val 
         435                440                445
Leu Asp Lys Leu Leu Phe His Ile Tyr Leu Leu Ala Val Leu Ala Tyr 
     450                455                460
Ser Ile Thr Leu Val Met Leu Trp Ser Ile Trp Gln Tyr Ala 
 465                470                475



<210> 8730
<211> 167
<212> DNA
<213> Rattus norvegicus
<308> U60578
<400> 8730

ccatctctc  agcctgaaa  taactttgt  aaattacat  atgttttta  atgtctcat  60
tccgtaaac  gaacttcaa  tcggagggg  aggctgaag  actgatggt  gacaactgg  120
gtccagctc  gccgctgaa  aacagaaag  tcaaggcgt  ctttaaa  167



<210> 8731
<211> 259
<212> PRT
<213> Rattus norvegicus
<308> AAC53104
<400> 8731

Ser His His Trp Gly Tyr Ser Lys Ser Asn Gly Pro Glu Asn Trp His 
  1               5                  10                  15
Lys Glu Phe Pro Ile Ala Asn Gly Asp Arg Gln Ser Pro Val Asp Ile 
             20                  25                  30
Asp Thr Gly Thr Ala Gln His Asp Pro Ser Leu Gln Pro Leu Leu Ile 
         35                  40                  45
Cys Tyr Asp Lys Val Ala Ser Lys Ser Ile Val Asn Asn Gly His Ser 
     50                  55                  60
Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Phe Ala Val Leu Lys Glu 
 65                  70                  75                  80
Gly Pro Leu Ser Gly Ser Tyr Arg Leu Ile Gln Phe His Phe His Trp 
                 85                  90                  95
Gly Ser Ser Asp Gly Gln Gly Ser Glu His Thr Val Asn Lys Lys Lys 
             100                105                110
Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly Asp 
         115                120                125
Phe Gly Lys Ala Val Gln His Pro Asp Gly Leu Ala Val Leu Gly Ile 
     130                135                140
Phe Leu Lys Ile Gly Pro Ala Ser Gln Gly Leu Gln Lys Ile Thr Glu 
 145                150                155                160
Ala Leu His Ser Ile Lys Thr Lys Gly Lys Arg Ala Ala Phe Ala Asn 
                 165                170                175
Phe Asp Pro Cys Ser Leu Leu Pro Gly Asn Leu Asp Tyr Trp Thr Tyr 
             180                185                190
Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp Ile 
         195                200                205
Val Leu Lys Glu Pro Ile Thr Val Ser Ser Glu Gln Met Ser His Phe 
     210                215                220
Arg Lys Leu Asn Phe Asn Ser Glu Gly Glu Ala Glu Glu Leu Met Val 
 225                230                235                240
Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Lys Ile Lys Ala 
                 245                250                255
Ser Phe Lys 
             260



<210> 8732
<211> 1551
<212> DNA
<213> Homo sapiens
<308> NM_000067
<400> 8732

ggcgcccaa  ccgccgccg  cagatcggt  ccgattcct  ccctgcccc  accgccagc  60
cgaccatgt  ccatcactg  gggtacggc  aacacaacg  acctgagca  tggcataag  120
acttcccca  tgccaaggg  gagcgccag  cccctgttg  catcgacac  catacagcc  180
agtatgacc  ttccctgaa  cccctgtct  tttcctatg  tcaagcaac  tccctgagg  240
tcctcaaca  tggtcatgc  ttcaacgtg  agtttgatg  ctctcagga  aaagcagtg  300
tcaagggag  acccctgga  ggcacttac  gattgattc  gtttcactt  cactggggt  360
cacttgatg  acaaggttc  gagcatact  tggataaaa  gaaatatgc  gcagaactt  420
acttggttc  ctggaacac  aaatatggg  attttggga  agctgtgca  caacctgat  480
gactggccg  tctaggtat  tttttgaag  ttggcagcg  taaaccggg  cttcagaaa  540
ttgttgatg  gctggattc  attaaaaca  agggcaaga  tgctgactt  actaacttc  600
atcctcgtg  cctccttcc  gaatccctg  attactgga  ctacccagg  tcactgacc  660
cccctcctc  tctggaatg  gtgacctgg  ttgtgctca  ggaacccat  agcgtcagc  720
gcgagcagg  gttgaaatt  cgtaaactt  acttcaatg  ggagggtga  cccgaagaa  780
tgatggtgg  caactggcg  ccagctcag  cactgaaga  caggcaaat  aaagcttcc  840
tcaaataag  tggtcccat  gtctgtatc  aaataatga  tcttcgggt  tttcccttt  900
gctaagcac  gatctacct  ggtgatttg  accctggtt  ctttgtgtc  agttttcta  960
acccttcat  tcttacttg  tagacttac  aataaaatg  gaagactag  ccaattgtc  1020
tgcttgaca  aactgctgt  gctggttgg  gctttgttt  tggtagtag  ttttctgta  1080
cacagaata  aggataaga  ataagaata  agtaccttg  ctttgttca  agcatgtag  1140
gtgatgagc  ctcacaatt  ttgactaaa  tgctgcttt  aaaacatag  aaagtagaa  1200
ggttgagtg  aaatccata  cacaagata  attgagcta  ttaaggcaa  tcaggtaaa  1260
tagtcatga  tctatgtaa  gtaaaccag  aaaaataaa  gttcatgat  tcaagatgt  1320
atattaaag  aaaacttta  aaattatta  atatttata  caaagttat  ttaaatatg  1380
attctgttg  aatttaatg  cttttgaat  acagagata  aaatgaagt  ttatctgta  1440
aaattgtta  aattagagt  gtgatacag  gtatatttc  attcagaca  tatatcata  1500
cttaataaa  attgtattt  agatatatt  tctaataaa  ttcagaatt  t  1551



<210> 8733
<211> 259
<212> PRT
<213> Homo sapiens
<308> P00918
<400> 8733

Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp His 
  1               5                  10                  15
Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp Ile 
             20                  25                  30
Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser Val 
         35                  40                  45
Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His Ala 
     50                  55                  60
Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys Gly 
 65                  70                  75                  80
Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His Trp 
                 85                  90                  95
Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys Lys 
             100                105                110
Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly Asp 
         115                120                125
Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly Ile 
     130                135                140
Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val Asp 
 145                150                155                160
Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr Asn 
                 165                170                175
Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr Tyr 
             180                185                190
Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp Ile 
         195                200                205
Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys Phe 
     210                215                220
Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met Val 
 225                230                235                240
Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys Ala 
                 245                250                255
Ser Phe Lys 
             260



<210> 8734
<211> 1201
<212> DNA
<213> Rattus norvegicus
<308> U60882
<400> 8734

agatggcgg  agccgaggc  gcgaactgc  tcatggagg  ttcctgtgg  caagcagaa  60
gtagtgaga  gcccaatgc  gaggacatg  catccaaag  ctactactt  gactcctat  120
cccactttg  catccacga  gagatgcta  aggatgagg  gcgaaccct  acgtaccgc  180
actccatgt  tcacaatcg  catctcttc  aagacaagg  ggtgctgga  gtgggctcg  240
gcactggca  cctctgcat  ttcgctgcc  aggcagggg  ccgcaaggt  attgggatc  300
agtgctcca  tatctctga  tatgctgtg  agattgtca  agccaataa  ttagaccac  360
tggtgacca  catcaaggg  aaggtggag  aggtggagc  gcctgtgga  aaggtggac  420
tcatcatca  cgagtggat  ggttattgc  tcttctatg  gtccatgct  aacactgtg  480
tgcacgctc  tgacaagtg  ctggcacct  atggcctca  cttcccaga  cgagccacc  540
tgtatgtga  agccattga  gaccgacag  ataaagact  caagatcca  tggtgggag  600
atgtatatg  ctttgatat  tcctgcatt  aagacgtgg  catcaagga  cccctggtg  660
acgtggtgg  cccaaagca  ctggtcacc  acgcctgcc  cataaagga  gtggacatc  720
acacagtca  ggtggagga  ctgaccttc  cctccccgt  ttgtctgca  gtgaagagg  780
atgactatg  gcatgcact  gtggcctac  tcaacatcg  gttcacccg  tgccacaag  840
ggaccggct  ctctaccag  cctgagtct  catacacac  ttggaagca  actgtgttc  900
acatggagg  ctacctaac  gtgaagacc  gcgaggaga  ttttggcac  attggaatg  960
ggcccaacg  caaaaacaa  cgtgacttg  actttacca  cgacctgga  ttcaagggt  1020
agctgtgtg  gctctcttg  tccaccgac  accggatgc  ctgaggagg  gccaggctg  1080
ccctcctgc  aaagggggc  caggggctg  gcttggggg  tgggagggt  catcgtggc  1140
gtgtttttc  taacttatg  ttttatatg  ttgcgttta  gccaataaa  cctcagctg  1200
c  1201



<210> 8735
<211> 353
<212> PRT
<213> Rattus norvegicus
<308> Q63009
<400> 8735

Met Ala Ala Ala Glu Ala Ala Asn Cys Ile Met Glu Val Ser Cys Gly 
  1               5                  10                  15
Gln Ala Glu Ser Ser Glu Lys Pro Asn Ala Glu Asp Met Thr Ser Lys 
             20                  25                  30
Asp Tyr Tyr Phe Asp Ser Tyr Ala His Phe Gly Ile His Glu Glu Met 
         35                  40                  45
Leu Lys Asp Glu Val Arg Thr Leu Thr Tyr Arg Asn Ser Met Phe His 
     50                  55                  60
Asn Arg His Leu Phe Lys Asp Lys Val Val Leu Asp Val Gly Ser Gly 
 65                  70                  75                  80
Thr Gly Ile Leu Cys Met Phe Ala Ala Lys Ala Gly Ala Arg Lys Val 
                 85                  90                  95
Ile Gly Ile Glu Cys Ser Ser Ile Ser Asp Tyr Ala Val Lys Ile Val 
             100                105                110
Lys Ala Asn Lys Leu Asp His Val Val Thr Ile Ile Lys Gly Lys Val 
         115                120                125
Glu Glu Val Glu Leu Pro Val Glu Lys Val Asp Ile Ile Ile Ser Glu 
     130                135                140
Trp Met Gly Tyr Cys Leu Phe Tyr Glu Ser Met Leu Asn Thr Val Leu 
 145                150                155                160
His Ala Arg Asp Lys Trp Leu Ala Pro Asp Gly Leu Ile Phe Pro Asp 
                 165                170                175
Arg Ala Thr Leu Tyr Val Thr Ala Ile Glu Asp Arg Gln Tyr Lys Asp 
             180                185                190
Tyr Lys Ile His Trp Trp Glu Asn Val Tyr Gly Phe Asp Met Ser Cys 
         195                200                205
Ile Lys Asp Val Ala Ile Lys Glu Pro Leu Val Asp Val Val Asp Pro 
     210                215                220
Lys Gln Leu Val Thr Asn Ala Cys Leu Ile Lys Glu Val Asp Ile Tyr 
 225                230                235                240
Thr Val Lys Val Glu Asp Leu Thr Phe Thr Ser Pro Phe Cys Leu Gln 
                 245                250                255
Val Lys Arg Asn Asp Tyr Val His Ala Leu Val Ala Tyr Phe Asn Ile 
             260                265                270
Glu Phe Thr Arg Cys His Lys Arg Thr Gly Phe Ser Thr Ser Pro Glu 
         275                280                285
Ser Pro Tyr Thr His Trp Lys Gln Thr Val Phe Tyr Met Glu Asp Tyr 
     290                295                300
Leu Thr Val Lys Thr Gly Glu Glu Ile Phe Gly Thr Ile Gly Met Arg 
 305                310                315                320
Pro Asn Ala Lys Asn Asn Arg Asp Leu Asp Phe Thr Ile Asp Leu Asp 
                 325                330                335
Phe Lys Gly Gln Leu Cys Glu Leu Ser Cys Ser Thr Asp Tyr Arg Met 
             340                345                350
Arg 
         355



<210> 8736
<211> 2606
<212> DNA
<213> Homo sapiens
<308> AK026786
<400> 8736

attctcttt  ctgtgaacc  ccagaacaa  ttgcttgaa  ttctcttgt  gaacaaacc  60
tattccagc  tctatcaga  acaataagg  tcttagaat  tagaaaaca  ggtcctggg  120
gggcacagt  cccacacgt  tatttcttc  acaggacct  cacgctgcc  tgctgttgg  180
gatctgtgc  gtaggcagt  gtggaatta  aagcaacac  ccatgtcgc  gaatgttca  240
ggatcacag  ccactgccg  ttcccaccc  ctcccagcc  ccggggagt  ttagcctgt  300
gagtcccag  aagcacatg  aaaagagag  cttggaacc  gagtggagt  acagctaag  360
ggtgctgga  gcccctgtg  ccttgatca  gcacaatgc  cagaccagc  ccgactttt  420
cctctcctt  acatattta  atggagtcg  tattggggt  agcttcatg  acggagcct  480
cttcagctt  agaggtgaa  agccccccc  cccagcccc  ccagcccgt  gtccctgct  540
agcccgtgc  atgcgtcca  catgtgtcc  ctcaaccca  ctgcccagg  cggggcaag  600
tgtccaagc  gctgaaccc  gaggagatg  cctcgagag  ttattactt  gactcctat  660
cccactttg  gatccacga  gaaatgctg  aggatgagg  gcggactct  acttaccgg  720
actccatgt  ccacaacaa  cacgtgttc  aggacaaag  ggtactgga  gtggggagt  780
gtactggga  cctttccat  ttcgctgcc  aggcagggg  caagaaggt  tttggggtg  840
cctcaccct  cctcaaggc  tggccagag  cgtcagaaa  tccctcagt  cccctttgc  900
agtacttct  aagggaatg  tccctgccc  aggcctggg  gtagtctga  gggccccca  960
gtgtggaga  cgaatgctc  agtatttct  actactcag  gaagatcat  aaggccaac  1020
acttggaca  catcatcac  atatttaag  gtaaagtgg  agaggtgga  ctgcctgtg  1080
agaaggtgg  catcatcat  agcgagtgg  tgggctact  tctgttcta  gagtccatg  1140
tcaacacgg  gatctttgc  agggacaag  ggctgaaac  tggagggct  atgtttcca  1200
accgggcag  tttgtacgt  gtagcgatt  aagacagac  gtacaagga  ttcaaaatc  1260
actggctac  gggaaataa  tggccagca  aaagaagaa  aaaaaatct  atcccttgg  1320
tgatctgtg  tctgaatga  tgaaggtgg  gcagtccag  tgaggagat  agacccaaa  1380
taacccata  aaagggtgg  agaatgtct  tggctttga  atgacctgc  tccgggacg  1440
ggccatgaa  gagcctcta  tggacatcg  ggatccaaa  caagtggtg  ccaatgcct  1500
tttgataaa  atacagcgc  acgactacg  ccacgccct  gtcacctat  ttaatattg  1560
atttaccaa  tgccacaag  aaatggggt  tcccacagc  cctgatgct  cctacaccc  1620
ctggaagca  accgtcttc  acttggaag  ttacctcac  gtccggagg  gggaggaaa  1680
ctacgggac  atatccatg  agccaaatg  caaaaaatg  gcgagacct  gatttcaca  1740
tagacttgg  ttttaaggg  cagctgtgt  aaacatctg  atctaatga  tacaaaatg  1800
gttagcaca  gtgggaagc  gcagagagc  acgagaaaa  gaactctca  ctcgatctg  1860
cgtgccgtc  caaagaata  cgtttgcag  actacacac  tgaaaacca  agttttcaa  1920
tctgccttg  agattggtg  actccccag  gctcccgtg  gctctgcca  tggacagaa  1980
gcctccagc  cctccgctc  gccctggta  cccttaacg  aggctttgt  ttgccaaca  2040
agagcgacc  ggcgtgctg  ggctgggcc  cgagggtgg  aacgtattc  cgtctcccc  2100
tctcctcct  aactgtgac  ctccgggtc  tctgagttt  gcatgctgc  ggtgtctag  2160
acagattgc  tccactaga  cctggagac  tagcatctt  gatagcata  gccagatta  2220
tctgtgtgt  cggtggtgt  cgtgtgcgt  catgtgtga  tgtgagcag  atagttgat  2280
tttacccac  aacacctgt  tatgggtgc  tatacaacc  agtgggtag  cctaggtgt  2340
ctctcagag  ggtgtgtgt  tgtatgcgt  cgcgtgtgc  tagaatata  attactctc  2400
gaggagatt  tgttgcttt  gaataggaa  ttgttttgt  attagttcg  cccttcccc  2460
ccccttacc  gatgttaag  agctatgaa  cattctctg  actagttct  gtctccttt  2520
gactggact  tggctctga  ccttgagca  agtaccacg  actccgtgg  cgctcaata  2580
acacacatg  gaacaaaaa  aaaaaa  2606



<210> 8737
<211> 168
<212> PRT
<213> Homo sapiens
<308> AK026786
<400> 8737

Met Glu Ser Ile Leu Gly Ser Ala Ser Cys Thr Glu Pro Ser Ser Ala 
  1               5                  10                  15
Leu Glu Val Asn Ser Pro Pro Ser Gln Pro Pro Gln Pro Val Val Pro 
             20                  25                  30
Ala Lys Pro Val Gln Cys Val His His Val Ser Thr Gln Pro Ser Cys 
         35                  40                  45
Pro Gly Arg Gly Lys Met Ser Lys Leu Leu Asn Pro Glu Glu Met Thr 
     50                  55                  60
Ser Arg Asp Tyr Tyr Phe Asp Ser Tyr Ala His Phe Gly Ile His Glu 
 65                  70                  75                  80
Glu Met Leu Lys Asp Glu Val Arg Thr Leu Thr Tyr Arg Asn Ser Met 
                 85                  90                  95
Tyr His Asn Lys His Val Phe Lys Asp Lys Val Val Leu Asp Val Gly 
             100                105                110
Ser Gly Thr Gly Ile Leu Ser Met Phe Ala Ala Lys Ala Gly Ala Lys 
         115                120                125
Lys Val Phe Gly Val Pro Ser Pro Phe Leu Lys Ala Trp Pro Glu Ala 
     130                135                140
Ser Glu Thr Pro Ser Val Pro Leu Cys Glu Tyr Phe Ser Arg Glu Trp 
 145                150                155                160
Ser Leu Pro Glu Ala Trp Gly Ter 
                 165



<210> 8738
<211> 2431
<212> DNA
<213> Rattus norvegicus
<308> U61184
<400> 8738

tctcgacca  ggcggcgac  acagctaac  cagaaatga  atcagatgt  ccatcactg  60
gtcccacca  tgcttctgg  aatcccgga  ctgggattc  aggtggagg  gctgttgtc  120
agagggcta  taagcgacg  tcagggctg  attttgatg  tgaaggaga  gtgaacagt  180
aatttttga  atgtgacga  gagcagatg  gtaacgaca  agagcggtt  gccaggtcg  240
atgatgagc  gagctctgc  gataaagag  gacttgcca  ggaaaatca  agtgaaata  300
agcggcggc  acggaacaa  atgacagct  acatcacag  actgtcaga  atggtacct  360
cctgtagtg  cctggctcg  aaaccagac  agctaacca  cttacgcat  gctgtttct  420
acatgaagt  cttgagggg  acgggcaat  catccactg  cggctccta  aagccgtcc  480
tcctcactg  tcaggaact  aaacatttg  ttttggagg  agcagatgg  tttctgttt  540
ttgtctctt  tgagactgg  cgagtggtg  atgtctctg  ctcggtgac  cccgttttg  600
accagccac  gtctgaatg  tttgggagc  cactgtatg  ccaagtgca  ccagatgat  660
tggataaac  tcgagagca  ctttctact  cagaaaatg  cctaacagg  cggatcctg  720
atctgaaga  tggaacagt  aaaaaggaa  gtcagcagt  ttccatgag  atgtgcatg  780
gctcaagaa  atcgttcat  tgccggatg  ggtgtggca  cagctctgt  gaccctgtt  840
ccatgaata  actgagctt  ttgaggaac  gatgcagga  tggacttgg  tctgtgaag  900
aaggagagc  tcactttgt  gtagtccac  gcacaggtt  catcaaggc  tggccacca  960
caggtgtct  cctcccaga  gatgatcca  aggctggcc  ggggagcaa  ttctgccta  1020
tggccattg  caggctgca  gtaaccagt  ctcctaact  tacagatat  agtaacatc  1080
gtcagccaa  agagttcat  tccagacat  acattgaag  gatattcac  tttgtagat  1140
atcgttgtg  ggctactgt  ggctaccag  cacaggagc  cttaggaaa  aatattgta  1200
aattttgtc  tcctgaaga  caacaactt  taagagaca  ctttcagca  gtggtgaaa  1260
taaaaggcc  agtgctgtc  gtcatgttc  gattccgag  taagaaccg  gaatggctg  1320
ggatgagaa  aagctcctt  actttccaa  acccgtatt  agatgaaat  agtatattt  1380
tctgcacca  caccaacgt  aagaactct  gccaggaac  acggcctac  ttgtctaac  1440
caatccaga  gtcacagct  ggtccgaca  ctaatttat  cctagagat  ggtacaggt  1500
tcctggcat  caggcagca  cagcagcag  agcagcagc  gcagcagca  cagcagcag  1560
agacagaat  ggatatggt  ccaggaaga  atgggctgg  cagctatag  cattcccag  1620
tttctgtcc  gcccgtggc  actgcagga  cagaacaca  caagcccct  gagaagtca  1680
aaggtctct  tgtgcagga  agagatccg  ggttttcag  aatctatcc  aacatcagt  1740
cagatcaga  taaaggcct  tcctccagc  ctgtccctg  cacccaaca  ctgttctcc  1800
agggcagct  attccctcc  aacccccgg  cggcagaaa  tttcaggaa  agtggtctt  1860
cccctcccg  aaccattgt  cagccgtca  cttctgcag  gcagatatt  gcccagatt  1920
ctcgtcact  caaccttac  cagggatca  caccaactt  gacctctag  actcgccca  1980
gtttctctg  ccagctgcc  actcaggct  cagccaaga  tcgttcttc  caatttggt  2040
tgaacaact  tcagacttc  tcctccttc  gtgccatgt  tcttccggg  gctcccact  2100
cctcaccca  tactgctgc  taccctact  ttcctaacc  tggatccaa  tttcctcct  2160
agactggac  gacaacagg  cagttccag  cccggacag  agagggtgt  ggtgtctgg  2220
cacagtggc  aggccagca  ccccatcac  ggtctagtt  caatgagca  catgttcag  2280
caacatcag  acaaccaag  agccagcct  aggtctttc  agaaatgct  tccatgctg  2340
gggaccaga  caacaccta  aacaatgaa  agtttcctg  tctaactat  tttccccct  2400
tttctgaat  gaactattg  ggtgaggat  a  2431



<210> 8739
<211> 800
<212> PRT
<213> Rattus norvegicus
<308> P41739
<400> 8739

Met Ala Ala Thr Thr Ala Asn Pro Glu Met Thr Ser Asp Val Pro Ser 
  1               5                  10                  15
Leu Gly Pro Thr Ile Ala Ser Gly Asn Pro Gly Pro Gly Ile Gln Gly 
             20                  25                  30
Gly Gly Ala Val Val Gln Arg Ala Ile Lys Arg Arg Ser Gly Leu Asp 
         35                  40                  45
Phe Asp Asp Glu Gly Glu Val Asn Ser Lys Phe Leu Arg Cys Asp Asp 
     50                  55                  60
Glu Gln Met Cys Asn Asp Lys Glu Arg Phe Ala Arg Ser Asp Asp Glu 
 65                  70                  75                  80
Gln Ser Ser Ala Asp Lys Glu Arg Leu Ala Arg Glu Asn His Ser Glu 
                 85                  90                  95
Ile Glu Arg Arg Arg Arg Asn Lys Met Thr Ala Tyr Ile Thr Glu Leu 
             100                105                110
Ser Asp Met Val Pro Thr Cys Ser Ala Leu Ala Arg Lys Pro Asp Lys 
         115                120                125
Leu Thr Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg Gly 
     130                135                140
Thr Gly Asn Thr Ser Thr Asp Gly Ser Tyr Lys Pro Ser Phe Leu Thr 
 145                150                155                160
Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu 
                 165                170                175
Phe Ile Val Ser Cys Glu Thr Gly Arg Val Val Tyr Val Ser Asp Ser 
             180                185                190
Val Thr Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser Thr 
         195                200                205
Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln 
     210                215                220
Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly Arg Ile Leu Asp Leu Lys 
 225                230                235                240
Thr Gly Thr Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met Cys 
                 245                250                255
Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Thr Ser 
             260                265                270
Ser Val Asp Pro Val Ser Met Asn Arg Leu Ser Phe Leu Arg Asn Arg 
         275                280                285
Cys Arg Asn Gly Leu Gly Ser Val Lys Glu Gly Glu Pro His Phe Val 
     290                295                300
Val Val His Cys Thr Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly Val 
 305                310                315                320
Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys Phe Cys 
                 325                330                335
Leu Val Ala Ile Gly Arg Leu Gln Val Thr Ser Ser Pro Asn Cys Thr 
             340                345                350
Asp Met Ser Asn Ile Cys Gln Pro Thr Glu Phe Ile Ser Arg His Asn 
         355                360                365
Ile Glu Gly Ile Phe Thr Phe Val Asp His Arg Cys Val Ala Thr Val 
     370                375                380
Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu Phe Cys 
 385                390                395                400
His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln Val Val 
                 405                410                415
Lys Leu Lys Gly Gln Val Leu Ser Val Met Phe Arg Phe Arg Ala Lys 
             420                425                430
Asn Arg Glu Trp Leu Trp Met Arg Thr Ser Ser Phe Thr Phe Gln Asn 
         435                440                445
Pro Tyr Ser Asp Glu Met Ser Ile Phe Ile Cys Thr Asn Thr Asn Val 
     450                455                460
Lys Asn Ser Ser Gln Glu Pro Arg Pro Thr Leu Ser Asn Thr Ile Gln 
 465                470                475                480
Arg Ser Gln Leu Gly Pro Thr Thr Asn Leu Ser Leu Glu Met Gly Thr 
                 485                490                495
Gly Val Leu Ala Ser Arg Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
             500                505                510
Gln Gln Gln Gln Gln Gln Thr Glu Leu Asp Met Val Pro Gly Arg Asp 
         515                520                525
Gly Leu Ala Ser Tyr Ser His Ser Gln Val Ser Val Gln Pro Val Ala 
     530                535                540
Thr Ala Gly Ser Glu His Ser Lys Pro Leu Glu Lys Ser Glu Gly Leu 
 545                550                555                560
Phe Val Gln Asp Arg Asp Pro Arg Phe Ser Glu Ile Tyr Pro Asn Ile 
                 565                570                575
Ser Ala Asp Gln Ser Lys Gly Leu Ser Ser Ser Thr Val Pro Ala Thr 
             580                585                590
Gln Gln Leu Phe Ser Gln Gly Ser Ser Phe Pro Pro Asn Pro Arg Pro 
         595                600                605
Ala Glu Asn Phe Arg Asn Ser Gly Leu Thr Pro Pro Val Thr Ile Val 
     610                615                620
Gln Pro Ser Ser Ser Ala Gly Gln Ile Leu Ala Gln Ile Ser Arg His 
 625                630                635                640
Ser Asn Leu Thr Gln Gly Ser Ala Pro Thr Trp Thr Ser Ser Thr Arg 
                 645                650                655
Pro Gly Phe Ser Ala Gln Leu Pro Thr Gln Ala Thr Ala Lys Thr Arg 
             660                665                670
Ser Ser Gln Phe Gly Val Asn Asn Phe Gln Thr Ser Ser Ser Phe Ser 
         675                680                685
Ala Met Ser Leu Pro Gly Ala Pro Thr Ala Ser Pro Ser Thr Ala Ala 
     690                695                700
Tyr Pro Thr Leu Pro Asn Arg Gly Ser Asn Phe Pro Pro Glu Thr Gly 
 705                710                715                720
Gln Thr Thr Gly Gln Phe Gln Thr Arg Thr Ala Glu Gly Val Gly Val 
                 725                730                735
Trp Pro Gln Trp Gln Gly Gln Gln Pro His His Arg Ser Ser Ser Asn 
             740                745                750
Glu Gln His Val Gln Pro Thr Ser Ala Gln Pro Ser Ser Gln Pro Glu 
         755                760                765
Val Phe Gln Glu Met Leu Ser Met Leu Gly Asp Gln Ser Asn Thr Tyr 
     770                775                780
Asn Asn Glu Glu Phe Pro Asp Leu Thr Met Phe Pro Pro Phe Ser Glu 
 785                790                795                800



<210> 8740
<211> 1174
<212> DNA
<213> Homo sapiens
<308> AF001307
<400> 8740

atggcggct  ctcccactg  ggggggggt  gcgcggcgg  ggtggcatc  cggccatgg  60
ggcgactac  gccaacccc  aaatgacat  agatgtacc  tcactgggt  cagccattg  120
ctctggaaa  tctggacct  gaattcaag  tggaggagc  attgtccag  gggctatta  180
gcggcgacc  gggctggat  ttgatgatg  tggagaagg  aacagtaaa  ttttgaggt  240
tgatgatga  cagatgtct  acgataagg  gcggtttgc  aggtcggat  atgagcaga  300
ctctgcgga  aaagagaga  ttgccaggg  aaatcacag  gaaattgaa  ggcggcgac  360
gaacaagat  acagcctac  tcacagaac  gtcagatat  gtacccacc  gtagtgccc  420
ggctcgaaa  ccagacaag  taaccatct  acgcatggc  gtttctcac  tgaagtcct  480
gcggggaac  ggcaacaca  ccactgatg  ctcctataa  ccgtctttc  tcactgatc  540
ggaactgaa  catttgatc  tggaggcag  agatggctt  ctgtttatt  tctcatgtg  600
gacaggcag  gtggtgtat  tgtctgact  cgtgactcc  gttttgaac  agccacagt  660
tgaatggtt  ggcagcaca  tctatgatc  ggtgcaccc  gatgatgtg  ataaacttc  720
tgagcagct  tccacttca  aaaatgccc  gacagggcg  atcctggat  taaagactg  780
aacagtgaa  aaggaaggt  agcagtctt  catgagaat  tgtatgggc  caaggagat  840
gtttatttg  cgaatgagg  gtggcagta  ctctgtgga  ccagtttct  tgaataggc  900
gagctttgt  aggaacaga  gcaggaatg  acttggctc  gtaaaggat  gggaacctc  960
cttcgtggt  gtccactgc  caggctaca  caaggcctg  cccccagca  gtgtttccc  1020
cccagatga  gacccagcc  gaggtcttc  aggagatgc  gtccatgct  ggagatcag  1080
gcaacagct  caacaatga  gaattccct  atctaacta  gtttccccc  ttttcagaa  1140
agaactatt  gggtgagga  aaggggtgg  ggag  1174



<210> 8741
<211> 789
<212> PRT
<213> Homo sapiens
<308> P27540
<400> 8741

Met Ala Ala Thr Thr Ala Asn Pro Glu Met Thr Ser Asp Val Pro Ser 
  1               5                  10                  15
Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly 
             20                  25                  30
Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Leu Asp 
         35                  40                  45
Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp 
     50                  55                  60
Asp Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Ser Asp Asp Glu 
 65                  70                  75                  80
Gln Ser Ser Ala Asp Lys Glu Arg Leu Ala Arg Glu Asn His Ser Glu 
                 85                  90                  95
Ile Glu Arg Arg Arg Arg Asn Lys Met Thr Ala Tyr Ile Thr Glu Leu 
             100                105                110
Ser Asp Met Val Pro Thr Cys Ser Ala Leu Ala Arg Lys Pro Asp Lys 
         115                120                125
Leu Thr Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg Gly 
     130                135                140
Thr Gly Asn Thr Ser Thr Asp Gly Ser Tyr Lys Pro Ser Phe Leu Thr 
 145                150                155                160
Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu 
                 165                170                175
Phe Ile Val Ser Cys Glu Thr Gly Arg Val Val Tyr Val Ser Asp Ser 
             180                185                190
Val Thr Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser Thr 
         195                200                205
Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln 
     210                215                220
Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly Arg Ile Leu Asp Leu Lys 
 225                230                235                240
Thr Gly Thr Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met Cys 
                 245                250                255
Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser Ser 
             260                265                270
Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn Arg 
         275                280                285
Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe Val 
     290                295                300
Val Val His Cys Thr Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly Val 
 305                310                315                320
Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys Phe Cys 
                 325                330                335
Leu Val Ala Ile Gly Arg Leu Gln Val Thr Ser Ser Pro Asn Cys Thr 
             340                345                350
Asp Met Ser Asn Val Cys Gln Pro Thr Glu Phe Ile Ser Arg His Asn 
         355                360                365
Ile Glu Gly Ile Phe Thr Phe Val Asp His Arg Cys Val Ala Thr Val 
     370                375                380
Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu Phe Cys 
 385                390                395                400
His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln Val Val 
                 405                410                415
Lys Leu Lys Gly Gln Val Leu Ser Val Met Phe Arg Phe Arg Ser Lys 
             420                425                430
Asn Gln Glu Trp Leu Trp Met Arg Thr Ser Ser Phe Thr Phe Gln Asn 
         435                440                445
Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile Cys Thr Asn Thr Asn Val 
     450                455                460
Lys Asn Ser Ser Gln Glu Pro Arg Pro Thr Leu Ser Asn Thr Ile Gln 
 465                470                475                480
Arg Pro Gln Leu Gly Pro Thr Ala Asn Leu Pro Leu Glu Met Gly Ser 
                 485                490                495
Gly Gln Leu Ala Pro Arg Gln Gln Gln Gln Gln Thr Glu Leu Asp Met 
             500                505                510
Val Pro Gly Arg Asp Gly Leu Ala Ser Tyr Asn His Ser Gln Val Val 
         515                520                525
Gln Pro Val Thr Thr Thr Gly Pro Glu His Ser Lys Pro Leu Glu Lys 
     530                535                540
Ser Asp Gly Leu Phe Ala Gln Asp Arg Asp Pro Arg Phe Ser Glu Ile 
 545                550                555                560
Tyr His Asn Ile Asn Ala Asp Gln Ser Lys Gly Ile Ser Ser Ser Thr 
                 565                570                575
Val Pro Ala Thr Gln Gln Leu Phe Ser Gln Gly Asn Thr Phe Pro Pro 
             580                585                590
Thr Pro Arg Pro Ala Glu Asn Phe Arg Asn Ser Gly Leu Ala Pro Pro 
         595                600                605
Val Thr Ile Val Gln Pro Ser Ala Ser Ala Gly Gln Met Leu Ala Gln 
     610                615                620
Ile Ser Arg His Ser Asn Pro Thr Gln Gly Ala Thr Pro Thr Trp Thr 
 625                630                635                640
Pro Thr Thr Arg Ser Gly Phe Ser Ala Gln Gln Val Ala Thr Gln Ala 
                 645                650                655
Thr Ala Lys Thr Arg Thr Ser Gln Phe Gly Val Gly Ser Phe Gln Thr 
             660                665                670
Pro Ser Ser Phe Ser Ser Met Ser Leu Pro Gly Ala Pro Thr Ala Ser 
         675                680                685
Pro Gly Ala Ala Ala Tyr Pro Ser Leu Thr Asn Arg Gly Ser Asn Phe 
     690                695                700
Ala Pro Glu Thr Gly Gln Thr Ala Gly Gln Phe Gln Thr Arg Thr Ala 
 705                710                715                720
Glu Gly Val Gly Val Trp Pro Gln Trp Gln Gly Gln Gln Pro His His 
                 725                730                735
Arg Ser Ser Ser Ser Glu Gln His Val Gln Gln Pro Pro Ala Gln Gln 
             740                745                750
Pro Gly Gln Pro Glu Val Phe Gln Glu Met Leu Ser Met Leu Gly Asp 
         755                760                765
Gln Ser Asn Ser Tyr Asn Asn Glu Glu Phe Pro Asp Leu Thr Met Phe 
     770                775                780
Pro Pro Phe Ser Glu 
 785



<210> 8742
<211> 1428
<212> DNA
<213> Rattus norvegicus
<308> U61373
<400> 8742

atgcgaagt  tcagcctgg  gtggctgct  ggaggtatc  cccttctgg  ggcctcggc  60
tcctgcaac  ggaccgtga  tgcaccggg  cccaacagt  aagggagaa  tctgattgg  120
agattggac  cgccgcctc  catcactgg  aaaggggct  cagttgaac  aggcttttc  180
gttgatgaa  tctctgcat  cgtcctcac  gggaagctg  ccaccgtct  tctcccggt  240
atctacatc  ttgtctttg  aattggttt  cccagtaat  gtatggccc  ctgggtctt  300
ttcttccga  cgaagaaga  gcaccctgc  gtgatttac  tggccaacc  ggccttggc  360
gacctcctc  ctgtcatct  gttccccct  aagatctcc  accacctcc  tggcaacga  420
tggacctat  gggatgcgc  ctgcaaggt  ctcattggc  ttttctacg  caatatgta  480
tgctccatc  ttttcatga  ctgcctcag  gtgcagagg  actgggtga  cgtgaaccc  540
atgggacac  ccaggaaga  ggccaacat  gctgttggc  tctccctgg  catctggct  600
ctgattttt  tggtcacca  ccctctgta  gtcatgagg  agaccatct  cattccagc  660
ttgaacatc  ccacctgtc  cgacgtgct  cccgaggag  tcctggtgg  ggacatgtt  720
agttacttc  tctccctgg  cattggagt  tttctgttc  cagccctcc  tactgcgtc  780
gcctacgtg  tcatgatca  aacgctccg  tcttccgcc  tggacgagc  ctcggagaa  840
aaaaggcgg  gggctatcc  cctcatcat  acggtgctg  ccatgtact  catctgctt  900
gctcccagc  acgtgctgc  cgtcgtgca  tatttcctc  tcaaaagcc  gaggcagag  960
cacgtctac  ccctctacc  cgtcgccct  tgcctgtcc  ccctcaaca  ctgcataga  1020
ccctttgtc  actactttg  ttcgaaaga  ttcagggac  aggccagaa  cgcgctcct  1080
tgccgaagc  tccgcaccg  gaaacgcat  cagatatcg  tcacctcca  caagttctc  1140
aggaaatcc  gctcttact  ctccagctc  accagtgtt  aaacctcct  ctgagctgg  1200
tctgaggat  tggagccag  ttgatgatg  tgctggtga  gatgatgat  atgatgatg  1260
tgatgatgc  gatgatgct  atgatgctg  tgatgctga  gatgatgat  tatgtgtgt  1320
caattgtgc  tgcatgcgt  tgtgtgtgt  tgtgtgtgt  tgtgtgtgt  tgttaggga  1380
gccaccaca  cgcacgggg  tgtcatttc  attccaagt  gcactata  1428



<210> 8743
<211> 397
<212> PRT
<213> Rattus norvegicus
<308> Q63645
<400> 8743

Met Arg Ser Leu Ser Leu Ala Trp Leu Leu Gly Gly Ile Thr Leu Leu 
  1               5                  10                  15
Ala Ala Ser Ala Ser Cys Asn Arg Thr Val Asn Ala Pro Gly Pro Asn 
             20                  25                  30
Ser Lys Gly Arg Ser Leu Ile Gly Arg Leu Asp Thr Pro Pro Pro Ile 
         35                  40                  45
Thr Gly Lys Gly Ala Pro Val Glu Pro Gly Phe Ser Val Asp Glu Phe 
     50                  55                  60
Ser Ala Ser Val Leu Thr Gly Lys Leu Thr Thr Val Phe Leu Pro Val 
 65                  70                  75                  80
Ile Tyr Ile Ile Val Phe Val Ile Gly Leu Pro Ser Asn Gly Met Ala 
                 85                  90                  95
Leu Trp Val Phe Phe Phe Arg Thr Lys Lys Lys His Pro Ala Val Ile 
             100                105                110
Tyr Met Ala Asn Leu Ala Leu Ala Asp Leu Leu Ser Val Ile Trp Phe 
         115                120                125
Pro Leu Lys Ile Ser Tyr His Leu His Gly Asn Asp Trp Thr Tyr Gly 
     130                135                140
Asp Ala Leu Cys Lys Val Leu Ile Gly Phe Phe Tyr Gly Asn Met Tyr 
 145                150                155                160
Cys Ser Ile Leu Phe Met Thr Cys Leu Ser Val Gln Arg Tyr Trp Val 
                 165                170                175
Ile Val Asn Pro Met Gly His Ser Arg Lys Arg Ala Asn Ile Ala Val 
             180                185                190
Gly Val Ser Leu Ala Ile Trp Leu Leu Ile Phe Leu Val Thr Ile Pro 
         195                200                205
Leu Tyr Val Met Arg Gln Thr Ile Tyr Ile Pro Ala Leu Asn Ile Thr 
     210                215                220
Thr Cys His Asp Val Leu Pro Glu Glu Val Leu Val Gly Asp Met Phe 
 225                230                235                240
Ser Tyr Phe Leu Ser Leu Ala Ile Gly Val Phe Leu Phe Pro Ala Leu 
                 245                250                255
Leu Thr Ala Ser Ala Tyr Val Leu Met Ile Lys Thr Leu Arg Ser Ser 
             260                265                270
Ala Met Asp Glu His Ser Glu Lys Lys Arg Arg Arg Ala Ile Arg Leu 
         275                280                285
Ile Ile Thr Val Leu Ser Met Tyr Phe Ile Cys Phe Ala Pro Ser Asn 
     290                295                300
Val Leu Leu Val Val His Tyr Phe Leu Ile Lys Ser Gln Arg Gln Ser 
 305                310                315                320
His Val Tyr Ala Leu Tyr Leu Val Ala Leu Cys Leu Ser Thr Leu Asn 
                 325                330                335
Ser Cys Ile Asp Pro Phe Val Tyr Tyr Phe Val Ser Lys Asp Phe Arg 
             340                345                350
Asp Gln Ala Arg Asn Ala Leu Leu Cys Arg Ser Val Arg Thr Val Lys 
         355                360                365
Arg Met Gln Ile Ser Leu Thr Ser Asn Lys Phe Ser Arg Lys Ser Ser 
     370                375                380
Ser Tyr Ser Ser Ser Ser Thr Ser Val Lys Thr Ser Tyr 
 385                390                395



<210> 8744
<211> 2813
<212> DNA
<213> Homo sapiens
<308> BC012453
<400> 8744

ctgactttc  ctcggtgcg  ccagtggag  tctgagttt  gaatcggtg  cggcggatt  60
cccgcgcgc  cggcgtcgg  gcttccagg  ggatgcgga  ccccagcgc  gcgtggctg  120
tgggggccg  catcctgct  gcagcctct  tctcctgca  tggcaccat  caaggaacc  180
atagatcct  taaaggaag  agccttatt  gtaaggttg  tggcacatc  cacgtcact  240
gaaaaggag  tacagttga  acagtcttt  ctgtggatg  gttttctgc  tctgtcctc  300
ctggaaaac  gaccactgt  ttccttcca  ttgtctaca  aattgtgtt  gtggtgggt  360
tgccaagta  cggcatggc  ctgtgggtc  ttcttttcc  aactaagaa  aagcaccct  420
ctgtgattt  catggccaa  ctggccttg  ctgacctcc  ctctgtcat  tggttcccc  480
tgaagattg  ctatcacat  catggcaac  actggattt  tggggaagc  ctttgtaat  540
tgcttattg  ctttttcta  ggcaacatg  actgttcca  tctcttcat  acctgcctc  600
gtgtgcaga  gtattgggt  atcgtgaac  ccatggggc  ctccaggaa  aaggcaaac  660
ttgccattg  catctccct  gcaatatgg  tgctgattc  gctggtcac  atccctttg  720
atgtcgtga  gcagaccat  ttcattcct  ccctgaaca  cacgacctg  catgatgtt  780
tgcctgagc  gctcttggt  ggagacatg  tcaattact  cctctctct  gccattggg  840
tctttctgt  cccagcctt  ctcacagcc  ctgcctatg  gctgatgat  agaatgctg  900
gatcttctg  catggatga  aactcagag  agaaaagga  gagggccat  aaactcatt  960
tcactgtcc  ggccatgta  ctgatctgc  tcactccta  taaccttct  cttgtggtg  1020
attattttc  gattaagag  cagggccag  gccatgtct  tgccctgta  attgtagcc  1080
tctgcctct  tacccttaa  agctgcatc  acccctttg  ctattactt  gtttcacat  1140
atttcaggg  tcatgcaaa  aacgctctc  tttgccgaa  tgtccgcac  gtaaagcag  1200
tgcaagtat  cctcacctc  aagaaacac  ccaggaaat  cagctctta  tcttcaagt  1260
caaccactg  taagacctc  tattgagtt  tccaggtcc  cagatggga  ttgcacagt  1320
ggatgtgga  cctgtttaa  gttatgagg  cgtgtctgt  atttcctaa  caaaaaggt  1380
tcaccacat  ccatgtgga  gcagcacct  tcaggattg  taggagctc  cctgtttgc  1440
tgagaaaag  agtccccca  attaacatc  gtgtctgtt  cagaatctc  ctactcaga  1500
gaccccaga  actgaacca  cagaagcag  cttttcaga  gatggtgaa  acagaaacc  1560
agtaacttg  aaaaagtag  cttggtgtg  agactcact  ctcagctga  attatatat  1620
tacacatat  tatatatat  ttacatctg  gatcatgat  gacttgtta  ggcttcaag  1680
ccctcagag  tgatcagtc  aactgaacg  ccttacaaa  gaggaaacc  agataaatg  1740
gctgccaga  tcaggtttc  aatcaacag  agtgagatg  gattggaca  tagaatttc  1800
atgtccagt  agtgaggtt  ttgtaccac  tcatcaaaa  catggatct  ggctgggtg  1860
ggtgcctca  gcctgtaat  ctagcactt  gggaggctg  ggcaggcaa  cacttgagg  1920
caggagttc  agaccagcc  ggccatcat  gcgaaacct  atctctact  aaaatacaa  1980
agttaacca  gtgtgtggt  cacgtttgt  atcccagtt  ctcaggagg  tgaggcaca  2040
gaattgagt  tcactttaa  tcaggaggc  gaggttgca  tgagccgag  ttgcaccac  2100
gcactccag  ttgggtgat  aaataaaat  aaatagtcg  gaatcttgt  caaaatgca  2160
attcctcag  ttcaataat  agagctcag  ctgggaaca  ggcccagga  tctgtgtgg  2220
acaaacctg  atggtgttt  tgcacacag  gatttgaga  ccattgttc  gaatgctgc  2280
tccatttga  aaagtgccg  gataatttt  gaaaagaga  gcaaacaat  gtgtctctt  2340
tatgttcag  ttataatga  atctgtttg  tgacttatt  ggactttga  ttatttctt  2400
attaaccct  tgagttttt  tatgtatta  tattaaaga  aaatgcaat  aggatttta  2460
acatgtaaa  acaaatttt  tataacttt  gatgacttc  gtgaaattt  caggtagtc  2520
gagtaatag  ttgttttgc  acttagaat  gcatttgcc  cttagtatt  taaaaaata  2580
ttgttggag  atttattgt  agttttgtt  acttgttat  taatacaaa  ttataaagc  2640
ttcagaggg  ttggaccac  tctctttgg  aaatagttt  caacatatt  aagagatac  2700
tgatgccaa  atgacttta  acaacgatt  tatttgtga  ttttaaaaa  aattatttt  2760
ttgtgtaat  gatttataa  taacaaaat  ttttttaca  cttaaaaaa  aaa  2813



<210> 8745
<211> 397
<212> PRT
<213> Homo sapiens
<308> P55085
<400> 8745

Met Arg Ser Pro Ser Ala Ala Trp Leu Leu Gly Ala Ala Ile Leu Leu 
  1               5                  10                  15
Ala Ala Ser Leu Ser Cys Ser Gly Thr Ile Gln Gly Thr Asn Arg Ser 
             20                  25                  30
Ser Lys Gly Arg Ser Leu Ile Gly Lys Val Asp Gly Thr Ser His Val 
         35                  40                  45
Thr Gly Lys Gly Val Thr Val Glu Thr Val Phe Ser Val Asp Glu Phe 
     50                  55                  60
Ser Ala Ser Val Leu Thr Gly Lys Leu Thr Thr Val Phe Leu Pro Ile 
 65                  70                  75                  80
Val Tyr Thr Ile Val Phe Val Val Gly Leu Pro Ser Asn Gly Met Ala 
                 85                  90                  95
Leu Trp Val Phe Leu Phe Arg Thr Lys Lys Lys His Pro Ala Val Ile 
             100                105                110
Tyr Met Ala Asn Leu Ala Leu Ala Asp Leu Leu Ser Val Ile Trp Phe 
         115                120                125
Pro Leu Lys Ile Ala Tyr His Ile His Gly Asn Asn Trp Ile Tyr Gly 
     130                135                140
Glu Ala Leu Cys Asn Val Leu Ile Gly Phe Phe Tyr Gly Asn Met Tyr 
 145                150                155                160
Cys Ser Ile Leu Phe Met Thr Cys Leu Ser Val Gln Arg Tyr Trp Val 
                 165                170                175
Ile Val Asn Pro Met Gly His Ser Arg Lys Lys Ala Asn Ile Ala Ile 
             180                185                190
Gly Ile Ser Leu Ala Ile Trp Leu Leu Ile Leu Leu Val Thr Ile Pro 
         195                200                205
Leu Tyr Val Val Lys Gln Thr Ile Phe Ile Pro Ala Leu Asn Ile Thr 
     210                215                220
Thr Cys His Asp Val Leu Pro Glu Gln Leu Leu Val Gly Asp Met Phe 
 225                230                235                240
Asn Tyr Phe Leu Ser Leu Ala Ile Gly Val Phe Leu Phe Pro Ala Phe 
                 245                250                255
Leu Thr Ala Ser Ala Tyr Val Leu Met Ile Arg Met Leu Arg Ser Ser 
             260                265                270
Ala Met Asp Glu Asn Ser Glu Lys Lys Arg Lys Arg Ala Ile Lys Leu 
         275                280                285
Ile Val Thr Val Leu Ala Met Tyr Leu Ile Cys Phe Thr Pro Ser Asn 
     290                295                300
Leu Leu Leu Val Val His Tyr Phe Leu Ile Lys Ser Gln Gly Gln Ser 
 305                310                315                320
His Val Tyr Ala Leu Tyr Ile Val Ala Leu Cys Leu Ser Thr Leu Asn 
                 325                330                335
Ser Cys Ile Asp Pro Phe Val Tyr Tyr Phe Val Ser His Asp Phe Arg 
             340                345                350
Asp His Ala Lys Asn Ala Leu Leu Cys Arg Ser Val Arg Thr Val Lys 
         355                360                365
Gln Met Gln Val Ser Leu Thr Ser Lys Lys His Ser Arg Lys Ser Ser 
     370                375                380
Ser Tyr Ser Ser Ser Ser Thr Thr Val Lys Thr Ser Tyr 
 385                390                395



<210> 8746
<211> 1619
<212> DNA
<213> Rattus norvegicus
<308> U61729
<400> 8746

ccaacacgt  catggtcct  gccccgaac  ttccagcag  agcctccgc  gccgccccg  60
gacgcctgc  ccccgtcgt  tgccgagcc  cgcgccatg  ctgtcgtct  cgttccaca  120
cgagatctc  ctctgggcg  ccgctagcg  cgttgggtt  ctcggggcc  tcccgatgg  180
gagcccggc  ccgccgccc  tgccgcgcc  tccggaccc  cgcgctctg  cacccaccc  240
cttcctgcc  cacttcctc  gaggggacg  gccgtgcct  gcccgcgcc  cgcaccgct  300
caccgtcca  ctgcagctt  gtcccggcc  ctgccccac  gcagcgccc  agaagcggc  360
gaagaaaaa  gtgcgggcc  gcccggccg  gcagctccc  agccgcttc  accagtttc  420
gcagcaccg  ccgagcctg  agggtggcc  cagcccggt  ccggggccg  tcgcagcgc  480
ggaggagcg  ggtccaggg  ccactgccc  gctatacag  cagccccca  tcgcgaagg  540
ggttttaaa  tcaaagatg  gaaaatcgg  gaaaatttc  cctccccat  gccagcttg  600
gcatggtat  cacttgtgt  aacaaccaa  gataagcag  cagaaaagc  aatttaact  660
gccactaac  aagatcacc  ctgcaaaaa  gaatgaaaa  gacttttgg  aagattccg  720
ttcctctga  agaatgcag  agcaggaaa  aaagcctct  aaaaatact  agaacatta  780
gaataacca  ttgaagaaa  cagcatttc  aacagaagg  agccaaaag  aaaattacg  840
cggagccaa  ttcagcgac  caccgtccc  tagtgtcct  ccaaagcct  cgagtcact  900
gatgggaag  accactgag  atcccagcc  gagccggga  ctgatggca  tgcacttga  960
aacgctcct  aaagtgcag  cctaggctc  agtctgcag  gtgtattag  cacagattc  1020
cccccatcc  cggactgaa  gaagtggat  cggcagtgg  aatttgccg  atcgcagca  1080
ccgacacaa  gagcttatg  cacacaagc  gcttgtatt  tattttgta  tttgtaaat  1140
ctgtatacc  tgtattatg  gtatattgt  catacttga  aggtacatt  tagttttgt  1200
atgaaagta  gtattttcc  tgcggatgt  gtgggtgtt  tgtatatat  cagtggaga  1260
attttaagt  ggtgctaag  cacgtggaa  actgtttat  tgcacaggt  ctgacattt  1320
tttaagaac  gctgtcaaa  ctcaaaagt  aagatctaa  tgtgaacag  ttacctaat  1380
tactactga  gcttaagtc  ggcacaatc  ctgtaaaca  ggagtttgt  tttctctaa  1440
ttgacttga  ttttaatct  taattacta  aaagcttcc  atttttacc  aacttgact  1500
ctggatatc  gtatattgc  attattgaa  agatttaaa  cacctctaa  tttaaatac  1560
aacaaaatt  gttgtaatc  aattttaaa  caataataa  ttggcctcc  ccccttaaa  1619



<210> 8747
<211> 269
<212> PRT
<213> Rattus norvegicus
<308> AAB09057
<400> 8747

Met Val Ser Pro Ala Pro Pro Pro Leu Pro Arg Leu Pro Asp Pro Arg 
  1               5                  10                  15
Ala Leu Pro Pro Thr Leu Phe Leu Pro His Phe Leu Gly Gly Asp Gly 
             20                  25                  30
Pro Cys Leu Ala Arg Ala Ser His Arg Cys Thr Val Gln Leu Gln Leu 
         35                  40                  45
Gly Pro Gly Arg Cys Pro Thr Ala Ala Pro Lys Lys Arg Arg Lys Lys 
     50                  55                  60
Lys Val Arg Ala Ser Pro Ala Gly Gln Leu Pro Ser Arg Phe His Gln 
 65                  70                  75                  80
Phe Gln Gln His Arg Pro Ser Leu Glu Gly Gly Arg Ser Pro Val Pro 
                 85                  90                  95
Gly Pro Ile Ala Ala Gln Glu Glu Arg Gly Pro Gly Ala Thr Ala Leu 
             100                105                110
Leu Tyr Arg Gln Pro Pro Leu Ala Lys Glu Val Leu Lys Ser Lys Met 
         115                120                125
Gly Lys Ser Glu Lys Ile Ser Pro Pro His Ser Gln Leu Val His Gly 
     130                135                140
Ile His Leu Cys Glu Gln Pro Lys Ile Ser Arg Gln Lys Ser Lys Phe 
 145                150                155                160
Asn Leu Pro Leu Thr Lys Ile Thr Ser Ala Lys Arg Asn Glu Asn Asp 
                 165                170                175
Phe Trp Gln Asp Ser Ala Ser Ser Asp Arg Met Gln Lys Gln Glu Lys 
             180                185                190
Lys Pro Leu Lys Asn Thr Glu Asn Ile Lys Asn Asn His Leu Lys Lys 
         195                200                205
Ser Ala Phe Leu Thr Glu Gly Ser Gln Lys Glu Asn Tyr Ala Gly Ala 
     210                215                220
Lys Phe Ser Asp Pro Pro Ser Pro Ser Val Leu Pro Lys Pro Pro Ser 
 225                230                235                240
His Trp Met Gly Ser Thr Thr Glu Asn Pro Ser Gln Ser Arg Glu Leu 
                 245                250                255
Met Ala Val His Leu Lys Thr Leu Leu Lys Val Gln Thr 
             260                265



<210> 8748
<211> 616
<212> DNA
<213> Homo sapiens
<308> AW974441
<400> 8748

aaagggggg  ggccaaatt  ttattattg  tttaaaatt  gattacaac  aattttgtt  60
gtatttaaa  ttagaggtg  tttaaatct  cataatggc  atataccaa  atccagaaa  120
gaagtttgg  aaaaacggg  agctttcta  gaattgcag  ttaaaagtc  agttgtcaa  180
ttagagcaa  acagactcc  tgattacag  gattgtgcc  aatttcacc  tcagtagta  240
ataaggaaa  tgttcacag  tacatcttc  cttttgaga  ttgacagct  ttcttaaaa  300
aatttcggt  cctgtgcaa  taaacagtc  tccatgtgc  ttagcaccc  cttagacta  360
ctccactgt  tatatacaa  acaccacca  agctgcagg  caaaataca  actttcata  420
caaaactat  atgtcctct  aagtatgaa  aatgtacac  taatacatg  tatacagta  480
ttacaaaat  taaaatata  tacaagctg  ttgtgtgac  taagcttaa  tgggcggat  540
ctgcaacca  gcaaagttt  actgttgta  ccgtttcct  ttgagtcca  agatttggg  600
gaaattgat  tttccc  616



<210> 8749
<211> 327
<212> PRT
<213> Homo sapiens
<308> NP_006804
<400> 8749

Met Thr Val Val Ser Val Pro Gln Arg Glu Pro Leu Val Leu Gly Gly 
  1               5                  10                  15
Arg Leu Ala Pro Leu Gly Phe Ser Ser Arg Gly Tyr Phe Gly Ala Leu 
             20                  25                  30
Pro Met Val Thr Thr Ala Pro Pro Pro Leu Pro Arg Ile Pro Asp Pro 
         35                  40                  45
Arg Ala Leu Pro Pro Thr Leu Phe Leu Pro His Phe Leu Gly Gly Asp 
     50                  55                  60
Gly Pro Cys Leu Thr Pro Gln Pro Arg Ala Pro Ala Ala Leu Pro Asn 
 65                  70                  75                  80
Arg Ser Leu Ala Val Ala Gly Gly Thr Pro Arg Ala Ala Pro Lys Lys 
                 85                  90                  95
Arg Arg Lys Lys Lys Val Arg Ala Ser Pro Ala Gly Gln Leu Pro Ser 
             100                105                110
Arg Phe His Gln Tyr Gln Gln His Arg Pro Ser Leu Glu Gly Gly Arg 
         115                120                125
Ser Pro Ala Thr Gly Pro Ser Gly Ala Gln Glu Val Pro Gly Pro Ala 
     130                135                140
Ala Ala Leu Ala Pro Ser Pro Ala Ala Ala Ala Gly Thr Glu Gly Ala 
 145                150                155                160
Ser Pro Asp Leu Ala Pro Leu Arg Pro Ala Ala Pro Gly Gln Thr Pro 
                 165                170                175
Leu Arg Lys Glu Val Leu Lys Ser Lys Met Gly Lys Ser Glu Lys Ile 
             180                185                190
Ala Leu Pro His Gly Gln Leu Val His Gly Ile His Leu Tyr Glu Gln 
         195                200                205
Pro Lys Ile Asn Arg Gln Lys Ser Lys Tyr Asn Leu Pro Leu Thr Lys 
     210                215                220
Ile Thr Ser Ala Lys Arg Asn Glu Asn Asn Phe Trp Gln Asp Ser Val 
 225                230                235                240
Ser Ser Asp Arg Ile Gln Lys Gln Glu Lys Lys Pro Phe Lys Asn Thr 
                 245                250                255
Glu Asn Ile Lys Asn Ser His Leu Lys Lys Ser Ala Phe Leu Thr Glu 
             260                265                270
Val Ser Gln Lys Glu Asn Tyr Ala Gly Ala Lys Phe Ser Asp Pro Pro 
         275                280                285
Ser Pro Ser Val Leu Pro Lys Pro Pro Ser His Trp Met Gly Ser Thr 
     290                295                300
Val Glu Asn Ser Asn Gln Asn Arg Glu Leu Met Ala Val His Leu Lys 
 305                310                315                320
Thr Leu Leu Lys Val Gln Thr 
                 325



<210> 8750
<211> 2481
<212> DNA
<213> Rattus norvegicus
<308> U62316
<400> 8750

tctcactat  gggctcgag  ggccgcccg  gcaggtcgg  tggcgagga  acgtcaggg  60
acataaata  ataaataat  ccattcagc  gatgacagc  aggcgaggc  gctgcagct  120
ggcgggggg  ccgggagag  agcggtgcg  accgggtgt  agagccaga  ctgaggacc  180
aacccaggg  cttgcactt  ctaggttgt  ttcgtctcc  gtagaagct  agaaatgcc  240
tcagagtct  cagtaaagg  aacggcggc  ccgcctcca  tcccacttc  tccggacgg  300
gggtggggc  gggttgtag  ctgcgcatc  ttcatctcc  ttgggttct  ctatgcctt  360
cccaaagcc  tcacggtat  cttcaatga  atcaaggac  ttttcaaga  cacctccag  420
cagatcgcg  ggatatcct  cattatgct  gctgtcatg  acgcaggag  tcccatcag  480
agtgtgttg  tgaataact  tggcagccg  cctgtggtg  tagtaggag  attactgtg  540
tgtactgga  tgatcttgg  ttctttcag  agcagtgtg  tagaacttt  cctcaccgt  600
ggcttcatt  gaggtttag  attagcatt  aacctgcaa  cagccttaa  aataatcgg  660
aaatacttc  ataggaagc  accccttgc  aatggcttt  ccatggctg  aagtcctgt  720
ttcttaagc  cactggctc  tttcaatca  ttcctattt  acagctatg  ctggaaggg  780
agttttttg  ttttggggg  catattttt  cactcctgt  tggccgggt  cctcatgag  840
cctgttggg  caagtccac  tgctgcgaa  tctaaaagt  aggttggct  aagacaaga  900
tcaagtacg  agagactca  taaggtatc  acagcagaa  agattaatc  gtttttaga  960
ttcggcctt  ttacacata  aggattttt  atctacctg  ctggaaatg  cgtgttgtt  1020
ttagggatg  ttgccccta  tatattctt  gctccgtat  ctaaggaca  aggagtgga  1080
gactataat  cagctttct  gctgtctgt  atggctttt  ccgatatgt  tgctcggcc  1140
tcggtagga  taatagcca  cactagctt  atccgtcca  gaatccagt  cttgttcag  1200
gtggcaatc  tgttcactg  catatgcca  ctcctctgc  ccctagccc  ttcctacac  1260
gctttggtg  tctacgtta  attttttgg  ataggattt  gaagtatta  cagtctcct  1320
tttgaatgt  ttatggacc  ggttggagc  tccaggttc  ccagtgctg  ggggctcgt  1380
actatcgtg  agtgttgcc  agttcttcc  ggccctccc  tggctggta  attgctcga  1440
ataactgga  aatataaat  cctgtacat  gccagtggg  tagtcgtgt  atcatcagg  1500
atttaccta  tgatttgca  tgctataaa  tatagactt  tcgagaagg  aaggaagag  1560
gagaaagca  ggaggaaga  atcagcctc  caggcatcc  aagaaatgg  ggctttgag  1620
agatctaaa  aggacgatg  tactgtgaa  gtttcaaat  cacacaatc  tccctcaga  1680
agggacaaa  aaagtagta  ttaacaagt  tcatctccg  atcagtgtt  agaaattta  1740
ttatgagtt  ctttgtgtt  ttttcaatg  attgcaaag  attttagct  caacaaaag  1800
tcgcaaaca  taacgaaac  ggtatcttc  tcaatgacg  actaaaaat  agtgcttta  1860
tatttgtta  agatggtta  cttttgaga  tgtgcacat  aaaaatcca  acagctgct  1920
atctgcaca  caaagctgt  atgaaaatg  attttttta  atcttctgc  aacttttac  1980
tttagctat  gaatgagat  tgcatccca  accccggct  acctaagca  aattcaaca  2040
taattccac  taactaccc  cttcaaggt  catttttcg  cggatacta  gtcatgaag  2100
gaattgaag  caatcattc  ttctattca  cacacaaag  attacacat  tagccacgc  2160
aacactgag  aacgggata  cataaagaa  taaatgaat  tgagaaaat  attatcata  2220
tcattttta  gtcaaagga  ataagactc  ggcaagtgg  aatgtaata  atttgtgtg  2280
agtcatcca  tgtggtttc  aaataacag  ctatgttga  aattcaagt  ttattaact  2340
aaaacacgc  aaaggggaa  ctatctaca  tgggtgagt  tggctaaac  cccacacag  2400
tctactagt  ttcaccatc  ctctgccac  tttgtgcct  ttttatcca  atcacctgt  2460
tgcactgtt  cagcacaat  g  2481



<210> 8751
<211> 489
<212> PRT
<213> Rattus norvegicus
<308> Q63344
<400> 8751

Met Pro Ser Glu Ser Ser Val Lys Ala Thr Ala Ala Pro Pro Pro Phe 
  1               5                  10                  15
Pro Leu Pro Pro Asp Gly Gly Trp Gly Trp Val Val Val Cys Ala Ser 
             20                  25                  30
Phe Ile Ser Ile Gly Phe Ser Tyr Ala Phe Pro Lys Ala Val Thr Val 
         35                  40                  45
Phe Phe Asn Asp Ile Lys Asp Ile Phe Lys Thr Thr Ser Ser Gln Ile 
     50                  55                  60
Ala Trp Ile Ser Ser Ile Met Leu Ala Val Met Tyr Ala Gly Gly Pro 
 65                  70                  75                  80
Ile Ser Ser Val Leu Val Asn Asn Tyr Gly Ser Arg Pro Val Leu Ile 
                 85                  90                  95
Val Gly Gly Leu Leu Cys Cys Thr Gly Met Ile Leu Ala Ser Phe Ser 
             100                105                110
Ser Ser Val Ile Glu Leu Tyr Leu Thr Val Gly Phe Ile Gly Gly Leu 
         115                120                125
Gly Leu Ala Phe Asn Leu Gln Pro Ala Leu Thr Ile Ile Gly Lys Tyr 
     130                135                140
Phe Tyr Arg Lys Arg Pro Leu Ala Asn Gly Phe Ala Met Ala Gly Ser 
 145                150                155                160
Pro Val Phe Leu Ser Thr Leu Ala Pro Phe Asn Gln Phe Leu Phe Asn 
                 165                170                175
Ser Tyr Gly Trp Lys Gly Ser Phe Leu Ile Leu Gly Ala Ile Phe Leu 
             180                185                190
His Ser Cys Val Ala Gly Cys Leu Met Arg Pro Val Gly Pro Ser Pro 
         195                200                205
Arg Ala Ala Lys Ser Lys Ser Lys Val Gly Ser Arg Gln Asp Ser Ser 
     210                215                220
Thr Lys Arg Leu Ser Lys Val Ser Thr Ala Glu Lys Ile Asn Arg Phe 
 225                230                235                240
Leu Asp Phe Gly Leu Phe Thr His Arg Gly Phe Leu Ile Tyr Leu Ser 
                 245                250                255
Gly Asn Val Val Leu Phe Leu Gly Met Phe Ala Pro Ile Ile Phe Leu 
             260                265                270
Ala Pro Tyr Ala Lys Asp Lys Gly Val Asp Asp Tyr Asn Ser Ala Phe 
         275                280                285
Leu Leu Ser Val Met Ala Phe Thr Asp Met Phe Ala Arg Pro Ser Val 
     290                295                300
Gly Leu Ile Ala Asn Thr Ser Leu Ile Arg Pro Arg Ile Gln Tyr Leu 
 305                310                315                320
Phe Ser Val Ala Ile Met Phe Thr Gly Ile Cys His Leu Leu Cys Pro 
                 325                330                335
Leu Ala His Ser Tyr Thr Ala Leu Val Val Tyr Val Ile Phe Phe Gly 
             340                345                350
Ile Gly Phe Gly Ser Ile Ser Ser Leu Leu Phe Glu Cys Leu Met Asp 
         355                360                365
Gln Val Gly Ala Ser Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile 
     370                375                380
Val Glu Cys Cys Pro Val Leu Phe Gly Pro Pro Leu Ala Gly Lys Leu 
 385                390                395                400
Leu Asp Ile Thr Gly Gln Tyr Lys Tyr Leu Tyr Ile Ala Ser Gly Ile 
                 405                410                415
Val Val Leu Ser Ser Gly Ile Tyr Leu Leu Ile Cys Asn Ala Ile Asn 
             420                425                430
Tyr Arg Leu Leu Glu Lys Glu Arg Lys Arg Glu Lys Ala Arg Arg Lys 
         435                440                445
Lys Ser Ala Ser Gln Ala Ser Lys Glu Met Glu Ala Leu Ser Arg Ser 
     450                455                460
Lys Gln Asp Asp Val Thr Val Lys Val Ser Asn Thr His Asn Pro Pro 
 465                470                475                480
Ser Asp Arg Asp Lys Glu Ser Ser Ile 
                 485



<210> 8752
<211> 2104
<212> DNA
<213> Homo sapiens
<308> AF058056
<400> 8752

ggaaacttc  gcctcaggt  gggagagga  tccatagat  agggaaact  atgtcttgg  60
gaaatggaa  accatgttt  taaacacct  tcgccaggt  acttgaatt  ccactagag  120
agcagaaat  ccaccaatg  caagtgccc  acctgtgca  ccacctcca  atggaggat  180
gggttggat  gtggttgga  cagctttta  ctccattgg  ttttcctat  cattcccca  240
agctgtcac  gtattcttc  aagaaattc  gcaaatatt  cacactacc  acagtgaaa  300
agcatggat  tcatccatt  tgctggctg  tatgtacgc  ggaggtcct  taagtagtg  360
tttggtgaa  aaatacggc  gccggccgg  ggtgatagc  ggaggctta  tatgctgtc  420
tggaatggt  ttggcctcc  ttagtagca  cgtggtaca  ctgtacctc  ctatgggat  480
cattacagg  ttaggttta  ccttcaacc  gcaacccgc  ttaaccata  ttggcaaat  540
cttctatag  aagcgaccc  tggcaaatg  attggccat  gcaggaagt  ctgttttct  600
aagttcatt  gctcctttc  atcagtacc  ttttaatac  tttggctgg  aaggaagct  660
cctgatttt  ggaagtcta  ttttgaatg  ctgtgtggc  ggttccctc  tgagacccc  720
tggacccaa  caaaccact  ctaagtcta  aaataagac  ggcaaaaca  aagatgatt  780
aagcccaaa  aaaatcaaa  cgaagaaat  aacttggga  aaagttaat  agtatttag  840
tttctccct  tttaagcat  gaggatttc  gatatatct  tctggaaat  tcattatgt  900
cctaggttt  tttgccccc  ttatattct  ggctccata  gctaaagac  aaggaattg  960
tgagtactc  gcagctttt  tgctatctg  tatggcttt  gttgatatg  ttgctaggc  1020
ttctgtagg  ttaattgca  actccaaat  tattcgacc  cgaattcag  acttcttca  1080
ttttgcaat  atgttcaat  gagtgtgtc  cctcttgtg  ccactggca  aggactaca  1140
aagcctggt  ttatatgct  tattttttg  ccttggatt  gggagtgtt  gcagtgttc  1200
ctttgaaac  ctcatggac  tcgtgggtg  accaagatt  tccagtgcc  tcggacttg  1260
cacaattgt  gagtgtggc  cagttcttc  tggccctcc  cttgcaggt  aattggtgg  1320
tttaactgg  gaatataaa  acatgtaca  gtcctgtgg  gctattgtg  tagcagcaa  1380
cgtgtggct  ctcattggc  atgctatca  ctatagatt  cttgcaaag  aaaggaagg  1440
ggaaaatgc  aggcagaag  ccagagaat  tgaaccctt  agcaaatct  aacattcgg  1500
agatgttaa  gtcaaagtt  caaatgcac  gagtgtaac  tcagaaaga  aaactaaca  1560
ttaacaaga  tcacatctc  gatttcagt  tttatgact  tatctagga  tttgttttt  1620
attttgttt  tttaaagta  tagaaaagg  tttagctga  atgaggagt  acaattdaa  1680
gatggaggt  atattttcc  caatggcaa  ttttaaatt  gtttttaaa  acttactta  1740
ttgggtagt  aaattttga  attatgcat  gaaagaatc  atgctatag  tttatttcc  1800
tacctgact  tgggtgtgg  ggttaaaat  ctaatttta  agtcttcca  tgactttcg  1860
tcttggtta  atggagaat  ctgaatccc  aacccctgg  ttaagtagg  agaaggagg  1920
tgcctaatc  tacaaagtg  ccctttata  atttcattt  ttatttgat  ttaaagtat  1980
agatagagt  gagagacaa  taattatcc  ctcttacac  caaacacac  tactcccac  2040
tacttaccc  catgtacac  gagtatctg  agaataaaa  ccaaattca  aaaaaaaaa  2100
aaaa  2104



<210> 8753
<211> 478
<212> PRT
<213> Homo sapiens
<308> O60669
<400> 8753

Met Pro Pro Met Pro Ser Ala Pro Pro Val His Pro Pro Pro Asp Gly 
  1               5                  10                  15
Gly Trp Gly Trp Ile Val Val Gly Ala Ala Phe Ile Ser Ile Gly Phe 
             20                  25                  30
Ser Tyr Ala Phe Pro Lys Ala Val Thr Val Phe Phe Lys Glu Ile Gln 
         35                  40                  45
Gln Ile Phe His Thr Thr Tyr Ser Glu Ile Ala Trp Ile Ser Ser Ile 
     50                  55                  60
Met Leu Ala Val Met Tyr Ala Gly Gly Pro Val Ser Ser Val Leu Val 
 65                  70                  75                  80
Asn Lys Tyr Gly Ser Arg Pro Val Val Ile Ala Gly Gly Leu Leu Cys 
                 85                  90                  95
Cys Leu Gly Met Val Leu Ala Ser Phe Ser Ser Ser Val Val Gln Leu 
             100                105                110
Tyr Leu Thr Met Gly Phe Ile Thr Gly Leu Gly Leu Ala Phe Asn Leu 
         115                120                125
Gln Pro Ala Leu Thr Ile Ile Gly Lys Tyr Phe Tyr Arg Lys Arg Pro 
     130                135                140
Met Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Ser Ser 
 145                150                155                160
Leu Ala Pro Phe Asn Gln Tyr Leu Phe Asn Thr Phe Gly Trp Lys Gly 
                 165                170                175
Ser Phe Leu Ile Leu Gly Ser Leu Leu Leu Asn Ala Cys Val Ala Gly 
             180                185                190
Ser Leu Met Arg Pro Leu Gly Pro Asn Gln Thr Thr Ser Lys Ser Lys 
         195                200                205
Asn Lys Thr Gly Lys Thr Glu Asp Asp Ser Ser Pro Lys Lys Ile Lys 
     210                215                220
Thr Lys Lys Ser Thr Trp Glu Lys Val Asn Lys Tyr Leu Asp Phe Ser 
 225                230                235                240
Leu Phe Lys His Arg Gly Phe Leu Ile Tyr Leu Ser Gly Asn Val Ile 
                 245                250                255
Met Phe Leu Gly Phe Phe Ala Pro Ile Ile Phe Leu Ala Pro Tyr Ala 
             260                265                270
Lys Asp Gln Gly Ile Asp Glu Tyr Ser Ala Ala Phe Leu Leu Ser Val 
         275                280                285
Met Ala Phe Val Asp Met Phe Ala Arg Pro Ser Val Gly Leu Ile Ala 
     290                295                300
Asn Ser Lys Tyr Ile Arg Pro Arg Ile Gln Tyr Phe Phe Ser Phe Ala 
 305                310                315                320
Ile Met Phe Asn Gly Val Cys His Leu Leu Cys Pro Leu Ala Gln Asp 
                 325                330                335
Tyr Thr Ser Leu Val Leu Tyr Ala Val Phe Phe Gly Leu Gly Phe Gly 
             340                345                350
Ser Val Ser Ser Val Leu Phe Glu Thr Leu Met Asp Leu Val Gly Ala 
         355                360                365
Pro Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile Val Glu Cys Gly 
     370                375                380
Pro Val Leu Leu Gly Pro Pro Leu Ala Gly Lys Leu Val Asp Leu Thr 
 385                390                395                400
Gly Glu Tyr Lys Tyr Met Tyr Met Ser Cys Gly Ala Ile Val Val Ala 
                 405                410                415
Ala Ser Val Trp Leu Leu Ile Gly Asn Ala Ile Asn Tyr Arg Leu Leu 
             420                425                430
Ala Lys Glu Arg Lys Glu Glu Asn Ala Arg Gln Lys Ser Arg Glu Ser 
         435                440                445
Glu Pro Leu Ser Lys Ser Lys His Ser Glu Asp Val Asn Val Lys Val 
     450                455                460
Ser Asn Ala Gln Ser Val Thr Ser Glu Arg Glu Thr Asn Ile 
 465                470                475



<210> 8754
<211> 2481
<212> DNA
<213> Rattus norvegicus
<308> U62316
<400> 8754

tctcactat  gggctcgag  ggccgcccg  gcaggtcgg  tggcgagga  acgtcaggg  60
acataaata  ataaataat  ccattcagc  gatgacagc  aggcgaggc  gctgcagct  120
ggcgggggg  ccgggagag  agcggtgcg  accgggtgt  agagccaga  ctgaggacc  180
aacccaggg  cttgcactt  ctaggttgt  ttcgtctcc  gtagaagct  agaaatgcc  240
tcagagtct  cagtaaagg  aacggcggc  ccgcctcca  tcccacttc  tccggacgg  300
gggtggggc  gggttgtag  ctgcgcatc  ttcatctcc  ttgggttct  ctatgcctt  360
cccaaagcc  tcacggtat  cttcaatga  atcaaggac  ttttcaaga  cacctccag  420
cagatcgcg  ggatatcct  cattatgct  gctgtcatg  acgcaggag  tcccatcag  480
agtgtgttg  tgaataact  tggcagccg  cctgtggtg  tagtaggag  attactgtg  540
tgtactgga  tgatcttgg  ttctttcag  agcagtgtg  tagaacttt  cctcaccgt  600
ggcttcatt  gaggtttag  attagcatt  aacctgcaa  cagccttaa  aataatcgg  660
aaatacttc  ataggaagc  accccttgc  aatggcttt  ccatggctg  aagtcctgt  720
ttcttaagc  cactggctc  tttcaatca  ttcctattt  acagctatg  ctggaaggg  780
agttttttg  ttttggggg  catattttt  cactcctgt  tggccgggt  cctcatgag  840
cctgttggg  caagtccac  tgctgcgaa  tctaaaagt  aggttggct  aagacaaga  900
tcaagtacg  agagactca  taaggtatc  acagcagaa  agattaatc  gtttttaga  960
ttcggcctt  ttacacata  aggattttt  atctacctg  ctggaaatg  cgtgttgtt  1020
ttagggatg  ttgccccta  tatattctt  gctccgtat  ctaaggaca  aggagtgga  1080
gactataat  cagctttct  gctgtctgt  atggctttt  ccgatatgt  tgctcggcc  1140
tcggtagga  taatagcca  cactagctt  atccgtcca  gaatccagt  cttgttcag  1200
gtggcaatc  tgttcactg  catatgcca  ctcctctgc  ccctagccc  ttcctacac  1260
gctttggtg  tctacgtta  attttttgg  ataggattt  gaagtatta  cagtctcct  1320
tttgaatgt  ttatggacc  ggttggagc  tccaggttc  ccagtgctg  ggggctcgt  1380
actatcgtg  agtgttgcc  agttcttcc  ggccctccc  tggctggta  attgctcga  1440
ataactgga  aatataaat  cctgtacat  gccagtggg  tagtcgtgt  atcatcagg  1500
atttaccta  tgatttgca  tgctataaa  tatagactt  tcgagaagg  aaggaagag  1560
gagaaagca  ggaggaaga  atcagcctc  caggcatcc  aagaaatgg  ggctttgag  1620
agatctaaa  aggacgatg  tactgtgaa  gtttcaaat  cacacaatc  tccctcaga  1680
agggacaaa  aaagtagta  ttaacaagt  tcatctccg  atcagtgtt  agaaattta  1740
ttatgagtt  ctttgtgtt  ttttcaatg  attgcaaag  attttagct  caacaaaag  1800
tcgcaaaca  taacgaaac  ggtatcttc  tcaatgacg  actaaaaat  agtgcttta  1860
tatttgtta  agatggtta  cttttgaga  tgtgcacat  aaaaatcca  acagctgct  1920
atctgcaca  caaagctgt  atgaaaatg  attttttta  atcttctgc  aacttttac  1980
tttagctat  gaatgagat  tgcatccca  accccggct  acctaagca  aattcaaca  2040
taattccac  taactaccc  cttcaaggt  catttttcg  cggatacta  gtcatgaag  2100
gaattgaag  caatcattc  ttctattca  cacacaaag  attacacat  tagccacgc  2160
aacactgag  aacgggata  cataaagaa  taaatgaat  tgagaaaat  attatcata  2220
tcattttta  gtcaaagga  ataagactc  ggcaagtgg  aatgtaata  atttgtgtg  2280
agtcatcca  tgtggtttc  aaataacag  ctatgttga  aattcaagt  ttattaact  2340
aaaacacgc  aaaggggaa  ctatctaca  tgggtgagt  tggctaaac  cccacacag  2400
tctactagt  ttcaccatc  ctctgccac  tttgtgcct  ttttatcca  atcacctgt  2460
tgcactgtt  cagcacaat  g  2481



<210> 8755
<211> 489
<212> PRT
<213> Rattus norvegicus
<308> Q63344
<400> 8755

Met Pro Ser Glu Ser Ser Val Lys Ala Thr Ala Ala Pro Pro Pro Phe 
  1               5                  10                  15
Pro Leu Pro Pro Asp Gly Gly Trp Gly Trp Val Val Val Cys Ala Ser 
             20                  25                  30
Phe Ile Ser Ile Gly Phe Ser Tyr Ala Phe Pro Lys Ala Val Thr Val 
         35                  40                  45
Phe Phe Asn Asp Ile Lys Asp Ile Phe Lys Thr Thr Ser Ser Gln Ile 
     50                  55                  60
Ala Trp Ile Ser Ser Ile Met Leu Ala Val Met Tyr Ala Gly Gly Pro 
 65                  70                  75                  80
Ile Ser Ser Val Leu Val Asn Asn Tyr Gly Ser Arg Pro Val Leu Ile 
                 85                  90                  95
Val Gly Gly Leu Leu Cys Cys Thr Gly Met Ile Leu Ala Ser Phe Ser 
             100                105                110
Ser Ser Val Ile Glu Leu Tyr Leu Thr Val Gly Phe Ile Gly Gly Leu 
         115                120                125
Gly Leu Ala Phe Asn Leu Gln Pro Ala Leu Thr Ile Ile Gly Lys Tyr 
     130                135                140
Phe Tyr Arg Lys Arg Pro Leu Ala Asn Gly Phe Ala Met Ala Gly Ser 
 145                150                155                160
Pro Val Phe Leu Ser Thr Leu Ala Pro Phe Asn Gln Phe Leu Phe Asn 
                 165                170                175
Ser Tyr Gly Trp Lys Gly Ser Phe Leu Ile Leu Gly Ala Ile Phe Leu 
             180                185                190
His Ser Cys Val Ala Gly Cys Leu Met Arg Pro Val Gly Pro Ser Pro 
         195                200                205
Arg Ala Ala Lys Ser Lys Ser Lys Val Gly Ser Arg Gln Asp Ser Ser 
     210                215                220
Thr Lys Arg Leu Ser Lys Val Ser Thr Ala Glu Lys Ile Asn Arg Phe 
 225                230                235                240
Leu Asp Phe Gly Leu Phe Thr His Arg Gly Phe Leu Ile Tyr Leu Ser 
                 245                250                255
Gly Asn Val Val Leu Phe Leu Gly Met Phe Ala Pro Ile Ile Phe Leu 
             260                265                270
Ala Pro Tyr Ala Lys Asp Lys Gly Val Asp Asp Tyr Asn Ser Ala Phe 
         275                280                285
Leu Leu Ser Val Met Ala Phe Thr Asp Met Phe Ala Arg Pro Ser Val 
     290                295                300
Gly Leu Ile Ala Asn Thr Ser Leu Ile Arg Pro Arg Ile Gln Tyr Leu 
 305                310                315                320
Phe Ser Val Ala Ile Met Phe Thr Gly Ile Cys His Leu Leu Cys Pro 
                 325                330                335
Leu Ala His Ser Tyr Thr Ala Leu Val Val Tyr Val Ile Phe Phe Gly 
             340                345                350
Ile Gly Phe Gly Ser Ile Ser Ser Leu Leu Phe Glu Cys Leu Met Asp 
         355                360                365
Gln Val Gly Ala Ser Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile 
     370                375                380
Val Glu Cys Cys Pro Val Leu Phe Gly Pro Pro Leu Ala Gly Lys Leu 
 385                390                395                400
Leu Asp Ile Thr Gly Gln Tyr Lys Tyr Leu Tyr Ile Ala Ser Gly Ile 
                 405                410                415
Val Val Leu Ser Ser Gly Ile Tyr Leu Leu Ile Cys Asn Ala Ile Asn 
             420                425                430
Tyr Arg Leu Leu Glu Lys Glu Arg Lys Arg Glu Lys Ala Arg Arg Lys 
         435                440                445
Lys Ser Ala Ser Gln Ala Ser Lys Glu Met Glu Ala Leu Ser Arg Ser 
     450                455                460
Lys Gln Asp Asp Val Thr Val Lys Val Ser Asn Thr His Asn Pro Pro 
 465                470                475                480
Ser Asp Arg Asp Lys Glu Ser Ser Ile 
                 485



<210> 8756
<211> 2104
<212> DNA
<213> Homo sapiens
<308> AF058056
<400> 8756

ggaaacttc  gcctcaggt  gggagagga  tccatagat  agggaaact  atgtcttgg  60
gaaatggaa  accatgttt  taaacacct  tcgccaggt  acttgaatt  ccactagag  120
agcagaaat  ccaccaatg  caagtgccc  acctgtgca  ccacctcca  atggaggat  180
gggttggat  gtggttgga  cagctttta  ctccattgg  ttttcctat  cattcccca  240
agctgtcac  gtattcttc  aagaaattc  gcaaatatt  cacactacc  acagtgaaa  300
agcatggat  tcatccatt  tgctggctg  tatgtacgc  ggaggtcct  taagtagtg  360
tttggtgaa  aaatacggc  gccggccgg  ggtgatagc  ggaggctta  tatgctgtc  420
tggaatggt  ttggcctcc  ttagtagca  cgtggtaca  ctgtacctc  ctatgggat  480
cattacagg  ttaggttta  ccttcaacc  gcaacccgc  ttaaccata  ttggcaaat  540
cttctatag  aagcgaccc  tggcaaatg  attggccat  gcaggaagt  ctgttttct  600
aagttcatt  gctcctttc  atcagtacc  ttttaatac  tttggctgg  aaggaagct  660
cctgatttt  ggaagtcta  ttttgaatg  ctgtgtggc  ggttccctc  tgagacccc  720
tggacccaa  caaaccact  ctaagtcta  aaataagac  ggcaaaaca  aagatgatt  780
aagcccaaa  aaaatcaaa  cgaagaaat  aacttggga  aaagttaat  agtatttag  840
tttctccct  tttaagcat  gaggatttc  gatatatct  tctggaaat  tcattatgt  900
cctaggttt  tttgccccc  ttatattct  ggctccata  gctaaagac  aaggaattg  960
tgagtactc  gcagctttt  tgctatctg  tatggcttt  gttgatatg  ttgctaggc  1020
ttctgtagg  ttaattgca  actccaaat  tattcgacc  cgaattcag  acttcttca  1080
ttttgcaat  atgttcaat  gagtgtgtc  cctcttgtg  ccactggca  aggactaca  1140
aagcctggt  ttatatgct  tattttttg  ccttggatt  gggagtgtt  gcagtgttc  1200
ctttgaaac  ctcatggac  tcgtgggtg  accaagatt  tccagtgcc  tcggacttg  1260
cacaattgt  gagtgtggc  cagttcttc  tggccctcc  cttgcaggt  aattggtgg  1320
tttaactgg  gaatataaa  acatgtaca  gtcctgtgg  gctattgtg  tagcagcaa  1380
cgtgtggct  ctcattggc  atgctatca  ctatagatt  cttgcaaag  aaaggaagg  1440
ggaaaatgc  aggcagaag  ccagagaat  tgaaccctt  agcaaatct  aacattcgg  1500
agatgttaa  gtcaaagtt  caaatgcac  gagtgtaac  tcagaaaga  aaactaaca  1560
ttaacaaga  tcacatctc  gatttcagt  tttatgact  tatctagga  tttgttttt  1620
attttgttt  tttaaagta  tagaaaagg  tttagctga  atgaggagt  acaattdaa  1680
gatggaggt  atattttcc  caatggcaa  ttttaaatt  gtttttaaa  acttactta  1740
ttgggtagt  aaattttga  attatgcat  gaaagaatc  atgctatag  tttatttcc  1800
tacctgact  tgggtgtgg  ggttaaaat  ctaatttta  agtcttcca  tgactttcg  1860
tcttggtta  atggagaat  ctgaatccc  aacccctgg  ttaagtagg  agaaggagg  1920
tgcctaatc  tacaaagtg  ccctttata  atttcattt  ttatttgat  ttaaagtat  1980
agatagagt  gagagacaa  taattatcc  ctcttacac  caaacacac  tactcccac  2040
tacttaccc  catgtacac  gagtatctg  agaataaaa  ccaaattca  aaaaaaaaa  2100
aaaa  2104



<210> 8757
<211> 478
<212> PRT
<213> Homo sapiens
<308> O60669
<400> 8757

Met Pro Pro Met Pro Ser Ala Pro Pro Val His Pro Pro Pro Asp Gly 
  1               5                  10                  15
Gly Trp Gly Trp Ile Val Val Gly Ala Ala Phe Ile Ser Ile Gly Phe 
             20                  25                  30
Ser Tyr Ala Phe Pro Lys Ala Val Thr Val Phe Phe Lys Glu Ile Gln 
         35                  40                  45
Gln Ile Phe His Thr Thr Tyr Ser Glu Ile Ala Trp Ile Ser Ser Ile 
     50                  55                  60
Met Leu Ala Val Met Tyr Ala Gly Gly Pro Val Ser Ser Val Leu Val 
 65                  70                  75                  80
Asn Lys Tyr Gly Ser Arg Pro Val Val Ile Ala Gly Gly Leu Leu Cys 
                 85                  90                  95
Cys Leu Gly Met Val Leu Ala Ser Phe Ser Ser Ser Val Val Gln Leu 
             100                105                110
Tyr Leu Thr Met Gly Phe Ile Thr Gly Leu Gly Leu Ala Phe Asn Leu 
         115                120                125
Gln Pro Ala Leu Thr Ile Ile Gly Lys Tyr Phe Tyr Arg Lys Arg Pro 
     130                135                140
Met Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Ser Ser 
 145                150                155                160
Leu Ala Pro Phe Asn Gln Tyr Leu Phe Asn Thr Phe Gly Trp Lys Gly 
                 165                170                175
Ser Phe Leu Ile Leu Gly Ser Leu Leu Leu Asn Ala Cys Val Ala Gly 
             180                185                190
Ser Leu Met Arg Pro Leu Gly Pro Asn Gln Thr Thr Ser Lys Ser Lys 
         195                200                205
Asn Lys Thr Gly Lys Thr Glu Asp Asp Ser Ser Pro Lys Lys Ile Lys 
     210                215                220
Thr Lys Lys Ser Thr Trp Glu Lys Val Asn Lys Tyr Leu Asp Phe Ser 
 225                230                235                240
Leu Phe Lys His Arg Gly Phe Leu Ile Tyr Leu Ser Gly Asn Val Ile 
                 245                250                255
Met Phe Leu Gly Phe Phe Ala Pro Ile Ile Phe Leu Ala Pro Tyr Ala 
             260                265                270
Lys Asp Gln Gly Ile Asp Glu Tyr Ser Ala Ala Phe Leu Leu Ser Val 
         275                280                285
Met Ala Phe Val Asp Met Phe Ala Arg Pro Ser Val Gly Leu Ile Ala 
     290                295                300
Asn Ser Lys Tyr Ile Arg Pro Arg Ile Gln Tyr Phe Phe Ser Phe Ala 
 305                310                315                320
Ile Met Phe Asn Gly Val Cys His Leu Leu Cys Pro Leu Ala Gln Asp 
                 325                330                335
Tyr Thr Ser Leu Val Leu Tyr Ala Val Phe Phe Gly Leu Gly Phe Gly 
             340                345                350
Ser Val Ser Ser Val Leu Phe Glu Thr Leu Met Asp Leu Val Gly Ala 
         355                360                365
Pro Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile Val Glu Cys Gly 
     370                375                380
Pro Val Leu Leu Gly Pro Pro Leu Ala Gly Lys Leu Val Asp Leu Thr 
 385                390                395                400
Gly Glu Tyr Lys Tyr Met Tyr Met Ser Cys Gly Ala Ile Val Val Ala 
                 405                410                415
Ala Ser Val Trp Leu Leu Ile Gly Asn Ala Ile Asn Tyr Arg Leu Leu 
             420                425                430
Ala Lys Glu Arg Lys Glu Glu Asn Ala Arg Gln Lys Ser Arg Glu Ser 
         435                440                445
Glu Pro Leu Ser Lys Ser Lys His Ser Glu Asp Val Asn Val Lys Val 
     450                455                460
Ser Asn Ala Gln Ser Val Thr Ser Glu Arg Glu Thr Asn Ile 
 465                470                475



<210> 8759
<211> 146
<212> PRT
<213> Rattus norvegicus
<308> AAB05795
<400> 8759

Met Ala Arg Asn Val Leu Tyr Pro Leu Tyr Gln Leu Gly Gly Pro Gln 
  1               5                  10                  15
Leu Arg Val Phe Arg Thr Asn Phe Phe Ile Gln Leu Val Arg Pro Gly 
             20                  25                  30
Thr Ala Gln Pro Glu Asp Thr Val Gln Phe Arg Ile Pro Met Glu Met 
         35                  40                  45
Thr Arg Val Asp Leu Arg Asn Tyr Leu Glu Gln Ile Tyr Asn Val Pro 
     50                  55                  60
Val Ala Ala Val Arg Thr Arg Val Gln His Gly Ser Asn Arg Arg Arg 
 65                  70                  75                  80
Asp His Lys Asn Val Arg Ile Lys Lys Pro Asp Tyr Lys Val Ala Tyr 
                 85                  90                  95
Val Gln Leu Ala His Gly Gln Thr Phe Thr Phe Pro Asp Leu Phe Pro 
             100                105                110
Glu Lys Glu Pro Thr Ser Pro Asp Pro Leu Glu Glu Glu Leu Pro Gln 
         115                120                125
Gln Arg Gln Ser Ser Asp Pro Arg Cys Pro Gly Ile Pro Ser Trp Phe 
     130                135                140
Gly Leu 
 145



<210> 8760
<211> 700
<212> DNA
<213> Homo sapiens
<308> U26596
<400> 8760

gggcgggcg  gctgctcct  cgcctcgcg  accccggaa  cgcgcgtgg  cgccatggc  600
cggaatgtg  tgtaccccc  gtaccggct  ggtggccca  aacttcggg  gttccgaac  660
aacttcttc  ttcagctgg  gcggcccgg  gtggcccagc  700



<210> 8761
<211> 153
<212> PRT
<213> Homo sapiens
<308> NP_066957
<400> 8761

Met Ala Arg Asn Val Val Tyr Pro Leu Tyr Arg Leu Gly Gly Pro Gln 
  1               5                  10                  15
Leu Arg Val Phe Arg Thr Asn Phe Phe Ile Gln Leu Val Arg Pro Gly 
             20                  25                  30
Val Ala Gln Pro Glu Asp Thr Val Gln Phe Arg Ile Pro Met Glu Met 
         35                  40                  45
Thr Arg Val Asp Leu Arg Asn Tyr Leu Glu Gly Ile Tyr Asn Val Pro 
     50                  55                  60
Val Ala Ala Val Arg Thr Arg Val Gln His Gly Ser Asn Lys Arg Arg 
 65                  70                  75                  80
Asp His Arg Asn Val Arg Ile Lys Lys Pro Asp Tyr Lys Val Ala Tyr 
                 85                  90                  95
Val Gln Leu Ala His Gly Gln Thr Phe Thr Phe Pro Asp Leu Phe Pro 
             100                105                110
Glu Lys Asp Glu Ser Pro Glu Gly Ser Ala Ala Asp Asp Leu Tyr Ser 
         115                120                125
Met Leu Glu Glu Glu Arg Gln Gln Arg Gln Ser Ser Asp Pro Arg Arg 
     130                135                140
Gly Gly Val Pro Ser Trp Phe Gly Leu 
 145                150



<210> 8762
<211> 1697
<212> DNA
<213> Rattus norvegicus
<308> U63740
<400> 8762

tagctggct  gcccgctgc  gttgcactg  accgggcca  ctctagccg  tggatgggg  60
tgtctggct  aaccccggg  tccgattcc  tcctccagg  cctgctcag  gaaacggat  120
ttgacagtt  ccatcattg  actacggtg  caggatgga  gctccactg  tgagtctgg  180
tgaagagtt  gaagatatc  ggccctgct  cactgagga  ccagaggaa  agccacaaa  240
tctctatgg  acatctcct  accacctgg  ggacccttc  ctctccgag  ttgagaatt  300
ttcttccga  ataatcagc  tcaagtcca  ggaggacct  gtgaatgaa  ttgatgaga  360
gctcaatgt  tgctttcgg  actacaatg  caagaccga  aacctggct  cagtgaaga  420
ccagttgca  atccaggag  aggaggaga  tcttcggga  gaggaggtt  gggatgctc  480
gacagacaa  tacatccct  cactctcag  agactggag  gacccaaac  ttgaagctc  540
gaatggcaa  agctctgac  ctgagatcc  cgagaagga  gaagaagat  agttcattg  600
gaagagtga  aacgactct  gtatcaacg  ggagcctct  ctcacagct  accaggtga  660
tgaggagat  gaagaaatg  tgcagaact  cccagatcc  gaggaggaa  tggaggtgc  720
ggaagagga  gatggagga  aaatctcgt  tcaggcaga  tcagtcctg  tacaagaga  780
gcaggccct  acgcagacc  tcaacaaca  ctggtccta  gaagggctg  gacacatgt  840
tgggtctga  ctgacagag  tgctggacc  ggtggaggg  gccatccgt  acttctcgg  900
ggagctggt  caccagctg  cccgcagag  tgagctgga  tttgagaag  aagtgaaga  960
ctctttcat  acggtgctc  ttgaggttc  gaataagca  aaggagcag  gggaactga  1020
gaagaagag  cggaaagag  aggggttaa  cctgcagag  agtcggata  agaagggga  1080
ccagatgcc  ctcaagcgt  tcagcatgg  gggcatctc  aacatcctg  agagtggca  1140
ccgccagac  tttggctcc  caggagctg  cagacagta  ctgaacaca  tcatccctt  1200
tgagaagaa  tcttctcct  cctctgtgg  agacctgca  atgctgaca  acattctct  1260
cgccatgaa  gaggataac  agaaggtgc  tactttgct  acggactac  ttttaaaag  1320
gctctgtcc  acctaacct  acctttgga  cagcctcac  gcaggaggt  actgagcaa  1380
aaagtcatt  catcactgg  attgcatga  accacgtaa  ctccggcgt  tatttaaac  1440
tgtatagct  aacctggat  aaacatgag  aaccgcgca  gcgcggggt  ctttgctgt  1500
ggcttctag  gctagtaat  attggatgc  tgatcgggc  tagggccag  gactctgct  1560
cctctaacc  gtgttgggg  agacaggtg  cctcaccac  cattatgta  tctggctcc  1620
gccctcaac  cagcttata  tcttcagac  aattttgaa  taaaccttc  tttaattaa  1680
atcaaaaaa  aaaaaaa  1697



<210> 8763
<211> 393
<212> PRT
<213> Rattus norvegicus
<308> P97577
<400> 8763

Met Glu Ala Pro Leu Val Ser Leu Asp Glu Glu Phe Glu Asp Ile Arg 
  1               5                  10                  15
Pro Cys Cys Thr Glu Asp Pro Glu Glu Lys Pro Gln Ser Leu Tyr Gly 
             20                  25                  30
Thr Ser Pro His His Leu Glu Asp Pro Ser Leu Ser Glu Leu Glu Asn 
         35                  40                  45
Phe Ser Ser Glu Ile Ile Ser Phe Lys Ser Met Glu Asp Leu Val Asn 
     50                  55                  60
Glu Phe Asp Glu Lys Leu Asn Val Cys Phe Arg Asn Tyr Asn Ala Lys 
 65                  70                  75                  80
Thr Glu Asn Leu Ala Pro Val Lys Asn Gln Leu Gln Ile Gln Glu Glu 
                 85                  90                  95
Glu Glu Thr Leu Arg Asp Glu Glu Val Trp Asp Ala Leu Thr Asp Asn 
             100                105                110
Tyr Ile Pro Ser Leu Ser Glu Asp Trp Arg Asp Pro Asn Ile Glu Ala 
         115                120                125
Leu Asn Gly Asn Ser Ser Asp Thr Glu Ile His Glu Lys Glu Glu Glu 
     130                135                140
Asp Glu Phe Ile Glu Lys Ser Glu Asn Asp Ser Gly Ile Asn Glu Glu 
 145                150                155                160
Pro Leu Leu Thr Ala Asp Gln Val Ile Glu Glu Ile Glu Glu Met Met 
                 165                170                175
Gln Asn Ser Pro Asp Pro Glu Glu Glu Val Glu Val Leu Glu Glu Glu 
             180                185                190
Asp Gly Gly Glu Ile Ser Ser Gln Ala Asp Ser Val Leu Leu Gln Glu 
         195                200                205
Met Gln Ala Leu Thr Gln Thr Phe Asn Asn Asn Trp Ser Tyr Glu Gly 
     210                215                220
Leu Arg His Met Ser Gly Ser Glu Leu Thr Glu Leu Leu Asp Gln Val 
 225                230                235                240
Glu Gly Ala Ile Arg Asp Phe Ser Glu Glu Leu Val His Gln Leu Ala 
                 245                250                255
Arg Arg Asp Glu Leu Glu Phe Glu Lys Glu Val Lys Asn Ser Phe Ile 
             260                265                270
Thr Val Leu Ile Glu Val Gln Asn Lys Gln Lys Glu Gln Arg Glu Leu 
         275                280                285
Met Lys Lys Arg Arg Lys Glu Lys Gly Leu Ser Leu Gln Ser Ser Arg 
     290                295                300
Ile Glu Lys Gly Asn Gln Met Pro Leu Lys Arg Phe Ser Met Glu Gly 
 305                310                315                320
Ile Ser Asn Ile Leu Gln Ser Gly Ile Arg Gln Thr Phe Gly Ser Ser 
                 325                330                335
Gly Ala Asp Arg Gln Tyr Leu Asn Thr Val Ile Pro Tyr Glu Lys Lys 
             340                345                350
Ser Ser Pro Pro Ser Val Glu Asp Leu Gln Met Leu Thr Asn Ile Leu 
         355                360                365
Phe Ala Met Lys Glu Asp Asn Glu Lys Val Pro Thr Leu Leu Thr Asp 
     370                375                380
Tyr Ile Leu Lys Val Leu Cys Pro Thr 
 385                390



<210> 8764
<211> 1654
<212> DNA
<213> Homo sapiens
<308> U60060
<400> 8764

acgagggtc  ggctgagcc  cgggatccg  ctccctccg  caggacccg  acagataaa  60
tcatcctga  agtcgctgt  gttctcctg  tgagcaaga  tggaggccc  actggtgag  120
ctggatgaa  agtttgagg  ccttcgacc  tcctgctcg  aggacccgg  ggagaagcc  180
cagtgtttc  atggttcat  tccccacca  ctcgaggac  cctccctct  cgagcttga  240
aatttttct  ccgaaataa  cagcttcaa  tccatggag  acctcgtaa  tgaatttga  300
gagaagctc  atgtctgct  tcggaacta  aacgccaag  ccgagaacc  agctcccgt  360
aagaaccag  tacagatcc  agaggagga  gagaccctt  aggacgagg  ggtttggga  420
gctctgaca  acaattaca  cccttcact  tcagaagac  ggagggatc  aaacatcga  480
gctctgaat  gcaactgct  tgacactga  atccatgag  aagaagagg  agagttcaa  540
gagaagagt  aaaatgatt  cggtatcaa  gaggagcct  tgctcacag  agatcaggt  600
attgaggag  ttgaggaaa  gatgcagaa  tccccagac  ctgaggaag  agaggaggt  660
ctggaagaa  aggatggag  agaaacttc  tcccaggca  actcggtcc  cctgcagga  720
atgcaggca  tgacacaga  cttcaacaa  aactggtcc  atgaagggc  gaggcacat  780
tctgggtct  agctgaccg  gctgctgga  caggtggag  gtgccatcc  tgacttctc  840
gaggagctg  tgcagcagc  ggcccgccg  gacgagctg  agtttgaga  ggaagtgaa  900
aactccttt  tcacggtgc  tattgaggt  cagaacaag  agaaggagc  gcgagaact  960
atgaaaaag  ggcggaaag  gaaagggct  agcctgcag  gcagccgga  agagaaggg  1020
aaccagatg  ctctcaagc  cttcagcat  gaaggcatc  ccaacattc  gcagagtgg  1080
atccgccag  cctttggct  ctcaggaac  gacaaacag  atctgaaca  agtcattcc  1140
tacgagaag  aagcctctc  tccctcagt  gaagacctg  agatgctga  aaacattct  1200
tttgccatg  aggaggata  tgagaaggt  cctactttg  taacggact  cattttaaa  1260
gtgctctgc  ctacctaac  ttgcccttt  gagcagcct  gctgcagga  gtcactgag  1320
aagagtcat  ccatcacag  gactgcatg  gaccatgta  cctccgaca  gtatttaaa  1380
gtgtatagc  taacctgga  taaacacga  caagcgcgc  gggtccttt  ccgttggct  1440
ctagtgcta  taatcattg  atgcatgat  gggcagggc  ggtgatggt  cctccccct  1500
gctggtgtc  ggagagggg  aggcagccg  tttcaccgc  cattatgta  tctggctac  1560
gccctccaa  acagcttat  ctcttaaga  taattttga  ataaaacct  catttaatt  1620
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  taaa  1654



<210> 8765
<211> 392
<212> PRT
<213> Homo sapiens
<308> Q99689
<400> 8765

Met Glu Ala Pro Leu Val Ser Leu Asp Glu Glu Phe Glu Asp Leu Arg 
  1               5                  10                  15
Pro Ser Cys Ser Glu Asp Pro Glu Glu Lys Pro Gln Cys Phe Tyr Gly 
             20                  25                  30
Ser Ser Pro His His Leu Glu Asp Pro Ser Leu Ser Glu Leu Glu Asn 
         35                  40                  45
Phe Ser Ser Glu Ile Ile Ser Phe Lys Ser Met Glu Asp Leu Val Asn 
     50                  55                  60
Glu Phe Asp Glu Lys Leu Asn Val Cys Phe Arg Asn Tyr Asn Ala Lys 
 65                  70                  75                  80
Thr Glu Asn Leu Ala Pro Val Lys Asn Gln Leu Gln Ile Gln Glu Glu 
                 85                  90                  95
Glu Glu Thr Leu Gln Asp Glu Glu Val Trp Asp Ala Leu Thr Asp Asn 
             100                105                110
Tyr Ile Pro Ser Leu Ser Glu Asp Trp Arg Asp Pro Asn Ile Glu Ala 
         115                120                125
Leu Asn Gly Asn Cys Ser Asp Thr Glu Ile His Glu Lys Glu Glu Glu 
     130                135                140
Glu Phe Asn Glu Lys Ser Glu Asn Asp Ser Gly Ile Asn Glu Glu Pro 
 145                150                155                160
Leu Leu Thr Ala Asp Gln Val Ile Glu Glu Ile Glu Glu Met Met Gln 
                 165                170                175
Asn Ser Pro Asp Pro Glu Glu Glu Glu Glu Val Leu Glu Glu Glu Asp 
             180                185                190
Gly Gly Glu Thr Ser Ser Gln Ala Asp Ser Val Leu Leu Gln Glu Met 
         195                200                205
Gln Ala Leu Thr Gln Thr Phe Asn Asn Asn Trp Ser Tyr Glu Gly Leu 
     210                215                220
Arg His Met Ser Gly Ser Glu Leu Thr Glu Leu Leu Asp Gln Val Glu 
 225                230                235                240
Gly Ala Ile Arg Asp Phe Ser Glu Glu Leu Val Gln Gln Leu Ala Arg 
                 245                250                255
Arg Asp Glu Leu Glu Phe Glu Lys Glu Val Lys Asn Ser Phe Ile Thr 
             260                265                270
Val Leu Ile Glu Val Gln Asn Lys Gln Lys Glu Gln Arg Glu Leu Met 
         275                280                285
Lys Lys Arg Arg Lys Glu Lys Gly Leu Ser Leu Gln Ser Ser Arg Ile 
     290                295                300
Glu Lys Gly Asn Gln Met Pro Leu Lys Arg Phe Ser Met Glu Gly Ile 
 305                310                315                320
Ser Asn Ile Leu Gln Ser Gly Ile Arg Gln Thr Phe Gly Ser Ser Gly 
                 325                330                335
Thr Asp Lys Gln Tyr Leu Asn Thr Val Ile Pro Tyr Glu Lys Lys Ala 
             340                345                350
Ser Pro Pro Ser Val Glu Asp Leu Gln Met Leu Thr Asn Ile Leu Phe 
         355                360                365
Ala Met Lys Glu Asp Asn Glu Lys Val Pro Thr Leu Leu Thr Asp Tyr 
     370                375                380
Ile Leu Lys Val Leu Cys Pro Thr 
 385                390



<210> 8766
<211> 1690
<212> DNA
<213> Rattus norvegicus
<308> U63972
<400> 8766

gaattcggc  cgagaccag  ggtggtggt  aggcatccc  agcgcaaga  gtcgggaga  60
gwcgagttt  acctgtttc  gaatatctc  tcagtgggg  cctgggatg  gcctcagta  120
cacattgct  ccgtctggg  cttccacct  caggcagcc  tcatgggat  tgtcttctt  180
gcagggacc  cactcaatg  cacagtgtt  gtggccaca  tgcactaca  aaagttgcg  240
cagcccctc  actacattc  ggtcaatgt  tccctcgga  gcttcctct  ctgcatctt  300
tctgtcttc  cagtcttca  cgccagctg  catggatac  tcctctttg  tcgccacgt  360
tgtgctctg  aggccttct  gggctctgt  gcaggtcta  tgacaggat  gtccttggc  420
ttcctggcc  ttgagcgct  ccttgtcat  tgtaaaccc  ttggcaaca  ccgcttcaa  480
tccaagcac  cactgacgg  ggttctgat  acttggacc  ttggcatcg  ggtgtccat  540
ccgcccttc  ttggctgga  caggttcat  cctgagggc  tgcagtgct  ctgtggccc  600
gactggtac  ccgtgggca  caagtatcg  agcgagcac  atacctggt  tctgttcat  660
ttctgtttc  tcattcctc  ttccctcat  tgtttctcc  acttccagt  gctgaggac  720
ctcagagct  tggcggccc  gcagcaaga  tcagctaca  ctcaaaagg  tgaacggga  780
gtgagccat  tggtggtgg  gatggtggg  tccttctgt  tctgctacg  gccctatgc  840
gccctggcc  tgtacatgg  caacaatcg  aaccacggg  tgtacttac  gcttgtcac  900
atccccgcc  tcttttcca  gagttcatg  gtctacaac  ccatcatct  ctgcttcat  960
aataagcag  tccgggcct  catcctgga  atggtgtgc  ggaagccca  gacagacga  1020
tctgacatg  ctggctctc  gaaaacaga  gtttctact  tttcttcca  caaagttgg  1080
cctcactaa  gaccctcag  tggcctgct  gcagcaacc  tggggccac  ttgaattat  1140
tacatctcc  ttagaattc  aaccattaa  aatgtaggg  acagacagg  gcagtggca  1200
ctggccggt  agtttcatt  tcctgttac  ctctccctg  cagcagggc  acacgggcc  1260
tttcaacag  cacagtttc  aagtgatac  ttcatctct  gagaactgt  agagaaggg  1320
cgtgcctct  gtgtatggg  aacacctgg  tgttctttt  ttccgtgct  ggatctgag  1380
tgatatatc  tgttagaat  agcttggca  ggggcagtg  gaagaaaaa  cagcagaca  1440
caaacacct  cagtgagct  aagctttcc  atgcggcct  tcccagttg  tgccgtctg  1500
gctatggct  ccctgccca  aactgcccc  cctcactca  ctgacagtt  ttctaagtc  1560
tctcccctc  atttggcta  atgtatcca  ttaaagctg  gtgttgatt  aagttagtg  1620
cttaatctc  tgacgacct  aaaaaaaaa  aaaaaaaac  cagagtact  ctagagcgc  1680
gcggcccatc  1690



<210> 8767
<211> 346
<212> PRT
<213> Rattus norvegicus
<308> Q63652
<400> 8767

Met Ser Gly Glu Xaa Glu Phe Tyr Leu Phe Gln Asn Ile Ser Ser Val 
  1               5                  10                  15
Gly Pro Trp Asp Gly Pro Gln Tyr His Ile Ala Pro Val Trp Ala Phe 
             20                  25                  30
His Leu Gln Ala Ala Phe Met Gly Phe Val Phe Phe Ala Gly Thr Pro 
         35                  40                  45
Leu Asn Ala Thr Val Leu Val Ala Thr Leu His Tyr Lys Lys Leu Arg 
     50                  55                  60
Gln Pro Leu Asn Tyr Ile Leu Val Asn Val Ser Leu Gly Gly Phe Leu 
 65                  70                  75                  80
Phe Cys Ile Phe Ser Val Phe Thr Val Phe Ile Ala Ser Cys His Gly 
                 85                  90                  95
Tyr Phe Leu Phe Gly Arg His Val Cys Ala Leu Glu Ala Phe Leu Gly 
             100                105                110
Ser Val Ala Gly Leu Val Thr Gly Trp Ser Leu Ala Phe Leu Ala Phe 
         115                120                125
Glu Arg Tyr Leu Val Ile Cys Lys Pro Phe Gly Asn Ile Arg Phe Asn 
     130                135                140
Ser Lys His Ala Leu Thr Val Val Leu Ile Thr Trp Thr Ile Gly Ile 
 145                150                155                160
Gly Val Ser Ile Pro Pro Phe Phe Gly Trp Ser Arg Phe Ile Pro Glu 
                 165                170                175
Gly Leu Gln Cys Ser Cys Gly Pro Asp Trp Tyr Thr Val Gly Thr Lys 
             180                185                190
Tyr Arg Ser Glu His Tyr Thr Trp Phe Leu Phe Ile Phe Cys Phe Ile 
         195                200                205
Ile Pro Leu Ser Leu Ile Cys Phe Ser Tyr Phe Gln Leu Leu Arg Thr 
     210                215                220
Leu Arg Ala Val Ala Ala Gln Gln Gln Glu Ser Ala Thr Thr Gln Lys 
 225                230                235                240
Ala Glu Arg Glu Val Ser His Met Val Val Val Met Val Gly Ser Phe 
                 245                250                255
Cys Leu Cys Tyr Val Pro Tyr Ala Ala Leu Ala Met Tyr Met Val Asn 
             260                265                270
Asn Arg Asn His Gly Leu Tyr Leu Arg Leu Val Thr Ile Pro Ala Phe 
         275                280                285
Phe Ser Lys Ser Ser Cys Val Tyr Asn Pro Ile Ile Tyr Cys Phe Met 
     290                295                300
Asn Lys Gln Phe Arg Ala Cys Ile Leu Glu Met Val Cys Arg Lys Pro 
 305                310                315                320
Met Thr Asp Glu Ser Asp Met Ser Gly Ser Gln Lys Thr Glu Val Ser 
                 325                330                335
Thr Val Ser Ser Ser Lys Val Gly Pro His 
             340                345



<210> 8768
<211> 1101
<212> DNA
<213> Homo sapiens
<308> NM_001708
<400> 8768

ggcatccat  agaaaaatg  cggaggaag  gttttatct  ttcaaaaat  tctcttcag  60
ggggccgtg  gatgggcct  agtaccaca  tgcccctgt  tgggccttc  acctccagg  120
agctttcat  ggcactgtc  tccttatag  gttcccact  aatgccatg  tgctggtgg  180
cacactgcg  tacaaaaag  tgcggcagc  cctcaacta  attctggtc  acgtgtcct  240
cggaggctt  ctcctctgc  tcttctctg  cttccctgt  ttcgtcgcc  gctgtaacg  300
atacttcgt  ttcggtcgc  atgtttgtg  tttggaggg  ttcctgggc  ctgtagcag  360
tctggttac  ggatggtca  tggccttcc  ggcctttga  cgctacatt  tcatctgta  420
gcccttcgg  aacttccgc  tcagctcca  gcatgcact  acggtggtc  tggctacct  480
gaccattgg  attggcgtc  ccatcccac  cttctttgg  tggagccgg  tcatccctg  540
gggcctgca  tgttcctgt  gccctgact  gtacaccgt  ggcaccaaa  accgcagcg  600
gtcctatac  tggttcctc  tcatcttct  cttcattgt  cctctctcc  tcatctgct  660
ctcctacac  cagctgctg  gggccctga  agctgttgc  gctcagcag  aggagtcag  720
tacgaccca  aaggctgaa  gggaggtga  ccgcatggt  gttgtgatg  taggatcct  780
ctgtgtctg  tacgtgccc  acgcggcct  cgccatgta  atggtcaac  accgtaacc  840
tgggctgga  ttacggctt  tcaccattc  ttcattctt  tccaagagt  cttgcatct  900
caatcccat  atctactgc  tcatgaata  gcagttcca  gcttgcatc  tgaagatgg  960
gtgtgggaa  gccatgaca  atgaatccg  cacatgcag  tcccagaaa  cagaagttt  1020
tactgtctc  tctacccaa  ttggcccca  ctgaggacc  aatattggc  tgtttgcaa  1080
agctagaat  aaattttac  t  1101



<210> 8769
<211> 348
<212> PRT
<213> Homo sapiens
<308> P03999
<400> 8769

Met Arg Lys Met Ser Glu Glu Glu Phe Tyr Leu Phe Lys Asn Ile Ser 
  1               5                  10                  15
Ser Val Gly Pro Trp Asp Gly Pro Gln Tyr His Ile Ala Pro Val Trp 
             20                  25                  30
Ala Phe Tyr Leu Gln Ala Ala Phe Met Gly Thr Val Phe Leu Ile Gly 
         35                  40                  45
Phe Pro Leu Asn Ala Met Val Leu Val Ala Thr Leu Arg Tyr Lys Lys 
     50                  55                  60
Leu Arg Gln Pro Leu Asn Tyr Ile Leu Val Asn Val Ser Phe Gly Gly 
 65                  70                  75                  80
Phe Leu Leu Cys Ile Phe Ser Val Phe Pro Val Phe Val Ala Ser Cys 
                 85                  90                  95
Asn Gly Tyr Phe Val Phe Gly Arg His Val Cys Ala Leu Glu Gly Phe 
             100                105                110
Leu Gly Thr Val Ala Gly Leu Val Thr Gly Trp Ser Leu Ala Phe Leu 
         115                120                125
Ala Phe Glu Arg Tyr Ile Val Ile Cys Lys Pro Phe Gly Asn Phe Arg 
     130                135                140
Phe Ser Ser Lys His Ala Leu Thr Val Val Leu Ala Thr Trp Thr Ile 
 145                150                155                160
Gly Ile Gly Val Ser Ile Pro Pro Phe Phe Gly Trp Ser Arg Phe Ile 
                 165                170                175
Pro Glu Gly Leu Gln Cys Ser Cys Gly Pro Asp Trp Tyr Thr Val Gly 
             180                185                190
Thr Lys Tyr Arg Ser Glu Ser Tyr Thr Trp Phe Leu Phe Ile Phe Cys 
         195                200                205
Phe Ile Val Pro Leu Ser Leu Ile Cys Phe Ser Tyr Thr Gln Leu Leu 
     210                215                220
Arg Ala Leu Lys Ala Val Ala Ala Gln Gln Gln Glu Ser Ala Thr Thr 
 225                230                235                240
Gln Lys Ala Glu Arg Glu Val Ser Arg Met Val Val Val Met Val Gly 
                 245                250                255
Ser Phe Cys Val Cys Tyr Val Pro Tyr Ala Ala Phe Ala Met Tyr Met 
             260                265                270
Val Asn Asn Arg Asn His Gly Leu Asp Leu Arg Leu Val Thr Ile Pro 
         275                280                285
Ser Phe Phe Ser Lys Ser Ala Cys Ile Tyr Asn Pro Ile Ile Tyr Cys 
     290                295                300
Phe Met Asn Lys Gln Phe Gln Ala Cys Ile Met Lys Met Val Cys Gly 
 305                310                315                320
Lys Ala Met Thr Asp Glu Ser Asp Thr Cys Ser Ser Gln Lys Thr Glu 
                 325                330                335
Val Ser Thr Val Ser Ser Thr Gln Val Gly Pro Asn 
             340                345



<210> 8770
<211> 952
<212> DNA
<213> Rattus norvegicus
<308> U64030
<400> 8770

ggcctccag  gccatgccg  tcttgtgcg  gctgctgcg  agccgactc  aaccttctc  60
gctccgctc  cttacgctc  cgtccgcgc  aagcctaag  tgcggcgga  gcagaggag  120
ccggacctg  agcgcgcgg  ccggacccg  agcgtgcgc  gaccctgcg  tctctgtct  180
taagagggc  cgagcggaa  atgacgctt  tctgcgttt  gtgcggctc  cggagcacg  240
tacggctcc  acccgcggg  ccgcgcgcg  tgcaggcta  gacctgtac  gtgcctatg  300
ttatacaat  ccatccatg  agaaagccc  tgtgaagac  gacattcag  tagctgttc  360
ttctgggtg  tatggaaga  tggctccac  ttctggctt  gctgtaaag  acttcatag  420
tgtaggagc  ggtgtcata  acgaagatt  tagaggaaa  gtcggcgtc  tgctgttca  480
ttttggaaa  gagaagttc  aggtgaaaa  aggtgaccg  atcgcgcag  tcatttgtg  540
gcggattct  tatccagac  tagaggagg  gcaaacact  gataacact  agagaggtt  600
aggaggctt  ggctccacg  gaaagaatt  aaactttgc  tgaagtact  tgctgtttg  660
acactgtaa  cgagcttta  tttcagaag  attttgtgt  ctaggatgt  ggaaaggat  720
cctatcacg  tggaactgc  ctgttctct  gttgatggt  gcctgtaaa  ctgtatcgt  780
agaactggc  gtgacatgc  gacttggtt  ttagatatt  tttttaaat  tggtattgt  840
tttaaatta  agtcctata  gaactgatt  tgctctaat  gctatatta  ttgtaattt  900
tttttttta  ccaataagt  cgaagtctt  agcgaaaaa  aaaaaaaaa  aa  952



<210> 8771
<211> 205
<212> PRT
<213> Rattus norvegicus
<308> P70583
<400> 8771

Met Pro Leu Leu Cys Ala Leu Leu Arg Ser Arg Leu Gln Pro Ser Leu 
  1               5                  10                  15
Leu Arg Ser Leu Thr Leu Thr Ser Ala Gln Ser Leu Ser Cys Gly Gly 
             20                  25                  30
Ser Arg Gly Val Arg Thr Trp Ser Ala Arg Thr Gly Pro Gly Ala Cys 
         35                  40                  45
Ala Asp Pro Ala Val Ser Val Ser Lys Arg Ala Arg Ala Glu Asp Asp 
     50                  55                  60
Ala Ser Leu Arg Phe Val Arg Leu Ser Glu His Ala Thr Ala Pro Thr 
 65                  70                  75                  80
Arg Gly Ser Ala Arg Ala Ala Gly Tyr Asp Leu Tyr Ser Ala Tyr Asp 
                 85                  90                  95
Tyr Thr Ile Pro Ser Met Glu Lys Ala Leu Val Lys Thr Asp Ile Gln 
             100                105                110
Ile Ala Val Pro Ser Gly Cys Tyr Gly Arg Val Ala Pro Arg Ser Gly 
         115                120                125
Leu Ala Val Lys His Phe Ile Asp Val Gly Ala Gly Val Ile Asp Glu 
     130                135                140
Asp Tyr Arg Gly Asn Val Gly Val Val Leu Phe Asn Phe Gly Lys Glu 
 145                150                155                160
Lys Phe Glu Val Lys Lys Gly Asp Arg Ile Ala Gln Leu Ile Cys Glu 
                 165                170                175
Arg Ile Leu Tyr Pro Asp Leu Glu Glu Val Gln Thr Leu Asp Asn Thr 
             180                185                190
Glu Arg Gly Ser Gly Gly Phe Gly Ser Thr Gly Lys Asn 
         195                200                205



<210> 8772
<211> 1816
<212> DNA
<213> Homo sapiens
<308> NM_001948
<400> 8772

ctcgccttc  ggctctgcc  tgccctgct  tgaagagac  cccgccatt  cacccagta  60
gcgggcccg  cctgcggag  tgggcggca  gcagctccg  tttgcccgg  tctccgagc  120
cgccacggc  cccacccgg  gctccgcgc  cgccgcggg  tacgacctg  acagtgcct  180
tgattacac  ataccacct  tggagaaag  tgttgtgaa  acggacatt  agatagcgc  240
cccttctgg  tgttatgga  gagtggctc  acggtcagg  ttggctgca  aacacttta  300
tgatgtagg  gctggtgtc  tagatgaag  ttatagagg  aatgttggt  ttgtactgt  360
taattttgg  aaagaaaag  ttgaagtca  aaaaggtga  cgaattgca  agctcattt  420
cgaacggat  ttttatcca  aaatagaag  agttcaagc  ttggatgac  ccgaaaggg  480
ttcaggagg  tttggttcc  ctggaaaga  ttaaaattt  tgccaagaa  agaaaacaa  540
aagtcatac  tttttctta  aaaaaaaaa  aaagttttt  cttcaagtg  tttggtgtt  600
tgcacttct  taaacttac  agctttacc  tctaaaagt  ctgcatttt  tactttttt  660
tatgatcaa  gaaaagatc  ttaaaaaaa  acacaaaga  gtttttctt  gtgtttgga  720
caaaaagaa  ctttgtttt  ccgcaattg  aggttgtat  taaatctgc  ttgtggtga  780
ctgatgtaa  cagtgtctt  ttaaaatca  atgtaaatc  attacagat  aaaaaaaaa  840
gcctgtatt  aactcatat  atctccctt  agcaactta  tttgcttta  ttgctttaa  900
tcttaagca  tatttttta  tcagtaaac  aattctttc  caaggtaca  aatcttgca  960
aagctgaac  aaaataaaa  tgaaaagga  agattaaag  tattccttg  tcttccctt  1020
tcttcacta  tctaaaaac  tctttttaa  cttaagatt  tttgtgatg  gggtgagaa  1080
aagaatcct  agtttattt  tccactatt  atctttctt  tgataaatc  tctattgac  1140
gggtagagg  atgtttgtg  aagacatgt  acttgggga  ttgttactt  aggtttgtt  1200
ccttgaatt  catctcatc  ggcaaattg  actagttgt  gttacgagt  ttccctcag  1260
gaagtagca  taggctgta  tcaagaaaa  atgccattt  tagagataa  ataaatgaa  1320
taatacttc  gccaccagg  ttttctgtc  cacatacat  agcagcatt  cattgcaga  1380
atgggactg  ttctgtggc  taccttgat  aacatcttt  ggaagtttt  ctagtgtgc  1440
ttcctttct  tactatgtt  ctcagattc  tttgtatca  ggttttggg  gtcacttag  1500
ttttgtcca  cagattctg  gagacacca  gcatcgttt  gaggatgtg  gttatacac  1560
tggagtgct  ctggaacta  cagcccact  gaccaccca  tttgtggaa  cacaggcaa  1620
agtgttctt  tctggtgat  ctccaggcc  tttaatacc  tgcaatgta  ttgtccctc  1680
gtggctcac  tttcattag  gagccatga  atcaactca  tgggacata  ccagcattt  1740
tgcatacca  gttgggcta  aaaatattt  tgttgtcaa  aaattttaa  tgttttcct  1800
ctaaaaaaa  aaaaaa  1816



<210> 8773
<211> 252
<212> PRT
<213> Homo sapiens
<308> P33316
<400> 8773

Met Thr Pro Leu Cys Pro Arg Pro Ala Leu Cys Tyr His Phe Leu Thr 
  1               5                  10                  15
Ser Leu Leu Arg Ser Ala Met Gln Asn Ala Arg Gly Thr Ala Glu Gly 
             20                  25                  30
Arg Ser Arg Gly Thr Leu Arg Ala Arg Pro Ala Pro Arg Pro Pro Ala 
         35                  40                  45
Ala Gln His Gly Ile Pro Arg Pro Leu Ser Ser Ala Gly Arg Leu Ser 
     50                  55                  60
Gln Gly Cys Arg Gly Ala Ser Thr Val Gly Ala Ala Gly Trp Lys Gly 
 65                  70                  75                  80
Glu Leu Pro Lys Ala Gly Gly Ser Pro Ala Pro Gly Pro Glu Thr Pro 
                 85                  90                  95
Ala Ile Ser Pro Ser Lys Arg Ala Arg Pro Ala Glu Val Gly Gly Met 
             100                105                110
Gln Leu Arg Phe Ala Arg Leu Ser Glu His Ala Thr Ala Pro Thr Arg 
         115                120                125
Gly Ser Ala Arg Ala Ala Gly Tyr Asp Leu Tyr Ser Ala Tyr Asp Tyr 
     130                135                140
Thr Ile Pro Pro Met Glu Lys Ala Val Val Lys Thr Asp Ile Gln Ile 
 145                150                155                160
Ala Leu Pro Ser Gly Cys Tyr Gly Arg Val Ala Pro Arg Ser Gly Leu 
                 165                170                175
Ala Ala Lys His Phe Ile Asp Val Gly Ala Gly Val Ile Asp Glu Asp 
             180                185                190
Tyr Arg Gly Asn Val Gly Val Val Leu Phe Asn Phe Gly Lys Glu Lys 
         195                200                205
Phe Glu Val Lys Lys Gly Asp Arg Ile Ala Gln Leu Ile Cys Glu Arg 
     210                215                220
Ile Phe Tyr Pro Glu Ile Glu Glu Val Gln Ala Leu Asp Asp Thr Glu 
 225                230                235                240
Arg Gly Ser Gly Gly Phe Gly Ser Thr Gly Lys Asn 
                 245                250



<210> 8774
<211> 976
<212> DNA
<213> Rattus norvegicus
<308> U64689
<400> 8774

gagaagctg  gcctgtgct  ccgccccac  tcggacgcc  accccccgc  ggcggccgt  60
cggcccatc  cggagcgca  cctcttgca  ggggacgag  tttggaatg  cctgacaga  120
aattatggg  atgtcatgc  tgtagactg  aagtcgtcc  atacgagga  cttgcattt  180
cttactctg  acctcacag  gaaagggat  agtgatggc  ttcccttcg  cacctcaga  240
gaggaggag  tgagggagc  gctggatat  cattcaatc  ttgtctcct  tgtcaacga  300
gagcccctc  tcactgcag  ccaggttat  gaagaaatt  aagaaatga  gcaggagtc  360
ccagaccta  aagacgatg  gacccccac  cagtcagac  ggctctcca  gctctccca  420
gagattcag  ctctcaaga  ctctagcat  agcagctgt  aagagcgag  gaaaaggct  480
tcagtgtct  agctaaacg  actgctgga  gaaattgag  cggccatta  ggagtactc  540
gaggagcta  tgcagcagt  ggccctgag  gatgagctg  agtttgaga  ggaagtgga  600
aacagcttt  tttctgctc  gattgaagt  cagaacaag  agaaagaac  caaggagac  660
gccaagaag  agaagaagc  caaaaatgg  agctctcag  atgggagga  tgagagaag  720
cacatgcca  gcacacgct  cagcatgga  gggatctca  atgtcattc  gaatggcct  780
cgccacacc  ttggaaact  aggtggaga  aaacagtat  tgacgacag  catccctta  840
gagaaaaag  atggcccgc  gtctgtgga  gatcttcaa  tattaacaa  aattctgca  900
gccatgaag  aggacagtg  gaaagttcc  agcttgtta  cggactata  actgaaagt  960
ctgtgtccg  cataga  976



<210> 8775
<211> 324
<212> PRT
<213> Rattus norvegicus
<308> P97578
<400> 8775

Glu Lys Leu Ser Leu Cys Phe Arg Pro Thr Ser Asp Ala Asp Pro Pro 
  1               5                  10                  15
Arg Ala Ala Val Arg Pro Ile Thr Glu Arg Ser Leu Leu Gln Gly Asp 
             20                  25                  30
Glu Ile Trp Asn Ala Leu Thr Asp Asn Tyr Gly Asn Val Met Pro Val 
         35                  40                  45
Asp Trp Lys Ser Ser His Thr Arg Thr Leu His Leu Leu Thr Leu Asn 
     50                  55                  60
Leu Thr Glu Lys Gly Met Ser Asp Gly Leu Pro Phe Asp Thr Ser Asp 
 65                  70                  75                  80
Glu Glu Glu Leu Arg Glu Gln Leu Asp Met His Ser Ile Ile Val Ser 
                 85                  90                  95
Cys Val Asn Glu Glu Pro Leu Phe Thr Ala Asp Gln Val Ile Glu Glu 
             100                105                110
Ile Glu Glu Met Met Gln Glu Ser Pro Asp Leu Glu Asp Asp Glu Thr 
         115                120                125
Pro Thr Gln Ser Asp Arg Leu Ser Met Leu Ser Gln Glu Ile Gln Thr 
     130                135                140
Leu Lys Ser Ser Ser Met Ser Ser Cys Glu Glu Arg Val Lys Arg Leu 
 145                150                155                160
Ser Val Ser Glu Leu Asn Glu Leu Leu Glu Glu Ile Glu Thr Ala Ile 
                 165                170                175
Lys Glu Tyr Ser Glu Glu Leu Val Gln Gln Leu Ala Leu Arg Asp Glu 
             180                185                190
Leu Glu Phe Glu Lys Glu Val Glu Asn Ser Phe Ile Ser Ala Leu Ile 
         195                200                205
Glu Val Gln Asn Lys Gln Lys Glu His Lys Glu Thr Ala Lys Lys Lys 
     210                215                220
Lys Lys Leu Lys Asn Gly Ser Ser Gln Asn Gly Arg Asn Glu Arg Ser 
 225                230                235                240
His Met Pro Gly Thr Arg Phe Ser Met Glu Gly Ile Ser Asn Val Ile 
                 245                250                255
Gln Asn Gly Leu Arg His Thr Phe Gly Asn Ser Gly Gly Glu Lys Gln 
             260                265                270
Tyr Leu Thr Thr Val Ile Pro Tyr Glu Lys Lys Asn Gly Pro Pro Ser 
         275                280                285
Val Glu Asp Leu Gln Ile Leu Thr Lys Ile Leu His Ala Met Lys Glu 
     290                295                300
Asp Ser Glu Lys Val Pro Ser Leu Leu Thr Asp Tyr Ile Leu Lys Val 
 305                310                315                320
Leu Cys Pro Thr 
                 325



<210> 8776
<211> 886
<212> DNA
<213> Homo sapiens
<308> U69140
<400> 8776

gactggaag  catcgcata  taggacctt  cacttgctt  ctctgaacc  ctcagaaaa  60
ggggtaagt  ncagtttgc  ctttgatac  tcagatgat  aagagctga  agaacagct  120
gatatgcac  caatcatcg  ctcctgtgt  aatgatgaa  ccctcttca  ggcagacca  180
gttattgaa  aaattgaag  aatgatgca  gaatcaccg  acccagaag  tgatgaaac  240
cctacacag  cagatcggc  ttcaatgct  tcccaggaa  ttcaaactc  caagaggtc  300
agtaccggc  gttatgaag  gagagtgaa  aggctctca  tgtctgagt  aaatgaaat  360
ctggaagaa  ttgagactg  cattaagga  tactctgag  agctggtgc  gcagttggc  420
ttacgagat  aactggagt  tgaaaagga  gtgaaaaac  gctttattt  tgttcttat  480
gaagtgcaa  acaaacaga  agagcacaa  gaaacagca  aaaagaaaa  gaaactaaa  540
aatggcagc  ctcagaatg  gaagaatga  agaagtcat  tgcccggca  atatttgac  600
acagtcatt  cttatgaga  aaaaaacgg  ccaccgtct  ttgaagatc  tcaaatatt  660
acaaaaatt  ttcgtgcca  gaaggagga  agtgaaaaa  ttccgagct  gttaactga  720
tatattctg  aagtgctgt  tcctacata  agcagcaac  ttatctgcg  tgggctcca  780
gctagattt  cgacagcat  attctgaga  ctggctacc  ttacccttc  tgctattgg  840
aactcagca  atttgaact  gggtttgat  cagtattaa  agatct  886



<210> 8777
<211> 320
<212> PRT
<213> Homo sapiens
<308> Q9UHY8
<400> 8777

Met Gly Glu Arg Arg Gly Arg Asp Gly Leu Gly Ala Pro Thr Val Ser 
  1               5                  10                  15
Arg Pro Trp Leu Gln Leu Gly Gly Glu Ala Glu Pro Val Leu Pro Pro 
             20                  25                  30
Leu Gly Ser Gly Arg Arg Ala Arg Gly Arg Pro Cys Gly His His Gly 
         35                  40                  45
Ala Gln Leu Leu Gln Gly Asp Glu Ile Trp Asn Ala Leu Thr Asp Asn 
     50                  55                  60
Tyr Gly Asn Val Met Pro Val Asp Trp Lys Ser Ser His Thr Arg Thr 
 65                  70                  75                  80
Leu His Leu Leu Thr Leu Asn Leu Ser Glu Lys Gly Val Ser Asp Ser 
                 85                  90                  95
Leu Leu Phe Asp Thr Ser Asp Asp Glu Glu Leu Arg Glu Gln Leu Asp 
             100                105                110
Met His Ser Ile Ile Val Ser Cys Val Asn Asp Glu Pro Leu Phe Thr 
         115                120                125
Ala Asp Gln Val Ile Glu Glu Ile Glu Glu Met Met Gln Glu Ser Pro 
     130                135                140
Asp Pro Glu Asp Asp Glu Thr Pro Thr Gln Ser Asp Arg Leu Ser Met 
 145                150                155                160
Leu Ser Gln Glu Ile Gln Thr Leu Lys Arg Ser Ser Thr Gly Ser Tyr 
                 165                170                175
Glu Glu Arg Val Lys Arg Leu Ser Val Ser Glu Leu Asn Glu Ile Leu 
             180                185                190
Glu Glu Ile Glu Thr Ala Ile Lys Glu Tyr Ser Glu Glu Leu Val Gln 
         195                200                205
Gln Leu Ala Leu Arg Asp Glu Leu Glu Phe Glu Lys Glu Val Lys Asn 
     210                215                220
Ser Phe Ile Ser Val Leu Ile Glu Val Gln Asn Lys Gln Lys Glu His 
 225                230                235                240
Lys Glu Thr Ala Lys Lys Lys Lys Lys Leu Lys Asn Gly Ser Ser Gln 
                 245                250                255
Asn Gly Lys Asn Glu Arg Ser His Met Pro Gly Thr Tyr Leu Thr Thr 
             260                265                270
Val Ile Pro Tyr Glu Lys Lys Asn Gly Pro Pro Ser Val Glu Asp Leu 
         275                280                285
Gln Ile Leu Thr Lys Ile Leu Arg Ala Met Lys Glu Asp Ser Glu Lys 
     290                295                300
Val Pro Ser Leu Leu Thr Asp Tyr Ile Leu Lys Val Leu Cys Pro Thr 
 305                310                315                320



<210> 8778
<211> 4189
<212> DNA
<213> Rattus norvegicus
<308> U65007
<400> 8778

atgaaggct  ccaccgcgc  ggcacctgg  attctgctg  tgctgctga  cttggcgca  60
aggagccat  gggagtgca  ggaggccct  gtgaagtct  agatgaacg  gaacatgaa  120
taccagctt  ccaacttca  cgcagaaac  cccatccag  atgtcgtcc  ccatgggca  180
catatttat  tcggagcca  aaactacat  tatgtttta  atgacaaag  ccttcagaa  240
gtatctgag  tcaagaccg  gcccgtggt  gaacaccca  attgttttc  ttgtcagga  300
tgcagcagc  aagccaatg  gtcaggagg  gtttggaaa  acaacgtca  catggcgct  360
cttgttgac  cttactatg  cgaccagct  atcagctgt  gcagcgtca  cagagggac  420
tgccaaagg  atgtccttc  tcctgacaa  gctgccgac  ttcagtccg  ggttcactg  480
atgttctcc  cacttgcgg  ggaagagtc  ggccagtgt  ccgactgtg  agtgagtgc  540
ctgggagcc  aagtcctcc  gtctgaaaa  gaccggttc  tcaatttct  cgtggggaa  600
acgataaac  cttcctacc  tcccgatta  tcattgcat  caatatcgg  gaggcggct  660
aaggaaacc  aggacggtt  taagttttt  acagaccag  cctacattg  tgtcctggg  720
gaattccga  attcctacc  catcaagta  atacatgcc  tcgaaagca  ccattttat  780
tactttctg  ctgtccaga  ggaaaccct  gatgctcag  ctttccata  aagaataat  840
aggttctgt  ctgtagact  tgggttgca  tcctacatg  aaatgcctc  ggagtgcat  900
ctgacggaa  aaagaagaa  gagatccac  agggaagaa  tgtttaata  cctccaagc  960
gcgtatgtc  gtaaaccag  ggccaatct  gctaagcaa  taggggcca  cccgtatga  1020
gacattctc  acggggtgt  tgcacaaag  aagccagat  ctgctgagc  catgaaccg  1080
tcagcggtc  gtgcattcc  catcaaata  gtcaatgac  tcttcaaca  gattgtcaa  1140
aaaaacaac  tacggtgtc  ccagcattt  tatggaccc  accacgagc  ctgtttcaa  1200
aggaccctg  tgagaaatt  atcgggctg  gaagtgcgc  gtgacgagt  ccggacgga  1260
tttaccaca  cgctgcagg  tgtggattt  ttcatgggc  ggctcaacc  tgtactctt  1320
acgtctatc  ctaccttca  caaaggtga  ctcaccatt  ctaatctag  gacatcaga  1380
ggtcgcttc  tgcaggtgg  gctctctcg  acagcacat  tcacccccc  tgtgaattt  1440
ctcctggat  cccatcctg  gtctccgga  gttattgtc  aacatccat  aaatcaaaa  1500
ggctatacc  tggtggtca  agggaagaa  atcaccaag  ttccactga  tggcctagg  1560
tgtgggcat  tccagtcct  cagtcagtg  ctctctgcc  cctacttta  acagtgtgg  1620
tggtgccac  atcggtgtg  gcattccaa  gaatgcccc  gcggtacat  gactcaaga  1680
atctgtctg  cagcagttt  taaggtttt  cccactagt  cacccctcg  aggaggaac  1740
atgctgacc  tatgtggct  ggactttgg  ttcaagaag  ataataaat  tgatttaag  1800
aaaaccaaa  ttctgcttg  caacgagag  tgtaccttg  ccttaagcg  gagcacgac  1860
aatacgttg  aatgcacag  tggccccgc  atgagtgag  acttcaatg  gtctgtgat  1920
gtctcaaac  gtcgagaga  aacacagta  agtgcgttt  cctatgtgg  tcctgtaat  1980
acaagtatt  ctccaaggt  tggtcctca  gccggaggc  ccttactca  tttgactgg  2040
aaatacctc  acagcggca  ttctagaca  atttcaatc  gagggaaaa  atgtacttt  2100
aaaagtgta  cagatagca  tctcgaatg  tacacccca  gccacaccg  ctctgccga  2160
tttcccgtg  aattgaaaa  cgacctggc  gaccgagtg  caagcagct  cagttacgg  2220
gaagacccg  ttgtctctg  aatccaccc  accaaatct  ttatcagtg  tggaagcac  2280
ataacgggg  ttggaaaga  cctgaattc  gttagcacc  caaagctgg  aatagaagt  2340
catgacgtg  gcgtgaact  caccgtggc  tgccaacat  gctcgagtt  agagatcat  2400
tgctgcacc  ctccttccc  gcaacagct  gacctgcaa  tccccctga  gaccaaagc  2460
ttcttcctg  tggacggga  cctttccaa  cactttgat  tcacttatg  acatgatcc  2520
atgtttaag  cttttgaaa  gccagtaat  atctccatg  gcaatgaga  tgtagtgga  2580
attaaggga  acgatattg  ccctgaagc  gttaaaggt  aagtgttaa  agtcgggaa  2640
aagagctgt  agaatctcc  ctggcattc  gaagctttg  tgtgtacgg  ccccagtga  2700
ctgctgaag  tgaacggcg  cgagctaaa  atagagtgg  agcaagcag  ctcttcaac  2760
gtccttgga  aagtgatcg  tcaaccgga  cagaatttt  caggattga  cattggtgc  2820
gtctcaata  cagtggtag  tttgttagt  tccgggctc  tcctgtggc  gagaaagag  2880
aagcataaa  atctgggca  tgaattagt  cgctatgac  caagagtac  cactcctca  2940
ttggatagg  ttgtaagtg  ccgaagtgt  agcccaact  cagagatgg  ctcaaatga  3000
tctgtagac  acagagcta  ttttccaga  gaccagttt  ccaactcct  tcagaatgg  3060
gcctgcaga  aagtgcagt  tccactgac  gatctgtcc  ccatcctga  gagtggaga  3120
tctgatata  ccagcccat  actacaaaa  actgttcac  ttgacctca  cgctctaaa  3180
ccagagctg  tccaagcgg  gcagcacgt  gtgattgga  ccagtagcc  gattgtgca  3240
ttcaatgaa  tcataggaa  agggcattt  ggctgtgtc  atcatggga  tttgttgga  3300
agtgacgga  agaaaattc  ctgtgctgt  aaatccttg  atagaatca  agatataga  3360
gaagtctcc  agtttctga  tgagggaat  atcatgaaa  atttcagcc  ccccaatgt  3420
ctctcactc  tgggaatct  cctgcggag  gaagggtcc  ctctggtgg  tctgcccta  3480
atgaagcac  gagatcttc  caatttcat  cgaaacgag  ctcataacc  aactgtgaa  3540
gatcttata  gattcggtc  tcaagtagc  aagggcatg  aatatcttg  cagcaaaaa  3600
tttgtccac  gagacttag  tgcaagaaa  tgcatgttg  atgaaaaat  cactgtcaa  3660
gttgctgat  tcggtcttg  cagagacat  tacgacaaa  agtattata  cgtccacaa  3720
aaaacgggt  cgaaactac  ggtgaagtg  atggcttta  agagtctgc  gacgcaaaa  3780
ttcaccacc  agtcagacg  gtggtcctt  ggtgtgctt  tctgggagc  catgacgag  3840
ggagcccct  cttatcctg  cgtgaacac  tttgatatc  ctatatacc  gttgcaagg  3900
agaagactc  tgcaaccag  gtactgtcc  gacgccttg  atgaagtga  gctaaaatg  3960
tggcacccc  aagcagaaa  gcgcccatc  ttttctgaa  tggtctcca  aatatcctc  4020
atcttctcc  ctttcattg  cgagcacta  gtccatgtg  acgctactt  tgtgaatgt  4080
aaatgtgtt  ctccatatc  ttctctgtt  ccatcccaa  acaacattg  cggcgaagc  4140
aacacatga  ggataagag  cccgccagc  cacttccaa  aaacagttc  4189



<210> 8779
<211> 1382
<212> PRT
<213> Rattus norvegicus
<308> P97523
<400> 8779

Met Lys Ala Pro Thr Ala Leu Ala Pro Gly Ile Leu Leu Leu Leu Leu 
  1               5                  10                  15
Thr Leu Ala Gln Arg Ser His Gly Glu Cys Lys Glu Ala Leu Val Lys 
             20                  25                  30
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
         35                  40                  45
Glu Thr Pro Ile His Asn Val Val Leu Pro Gly His His Ile Tyr Leu 
     50                  55                  60
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Asp Lys Asp Leu Gln Lys 
 65                  70                  75                  80
Val Ser Glu Phe Lys Thr Gly Pro Val Val Glu His Pro Asp Cys Phe 
                 85                  90                  95
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Val Ser Gly Gly Val Trp 
             100                105                110
Lys Asp Asn Val Asn Met Ala Leu Leu Val Asp Thr Tyr Tyr Asp Asp 
         115                120                125
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
     130                135                140
Val Leu Pro Pro Asp Asn Ala Ala Asp Ile Gln Ser Glu Val His Cys 
 145                150                155                160
Met Phe Ser Pro Leu Ala Glu Glu Glu Ser Gly Gln Cys Pro Asp Cys 
                 165                170                175
Val Val Ser Ala Leu Gly Ala Lys Val Leu Leu Ser Glu Lys Asp Arg 
             180                185                190
Phe Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Pro Pro 
         195                200                205
Asp Tyr Ser Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Gln 
     210                215                220
Asp Gly Phe Lys Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro 
 225                230                235                240
Glu Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Ile His Ala Phe Glu Ser 
                 245                250                255
Asn His Phe Ile Tyr Phe Leu Thr Val Gln Lys Glu Thr Leu Asp Ala 
             260                265                270
Gln Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Val Asp Ser Gly 
         275                280                285
Leu His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys 
     290                295                300
Arg Arg Lys Arg Ser Thr Arg Glu Glu Val Phe Asn Ile Leu Gln Ala 
 305                310                315                320
Ala Tyr Val Ser Lys Pro Gly Ala Asn Leu Ala Lys Gln Ile Gly Ala 
                 325                330                335
Ser Pro Tyr Asp Asp Ile Leu Tyr Gly Val Phe Ala Gln Ser Lys Pro 
             340                345                350
Asp Ser Ala Glu Pro Met Asn Arg Ser Ala Val Cys Ala Phe Pro Ile 
         355                360                365
Lys Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val 
     370                375                380
Arg Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn 
 385                390                395                400
Arg Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Val Arg Ser Asp Glu 
                 405                410                415
Tyr Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met 
             420                425                430
Gly Arg Leu Asn His Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys 
         435                440                445
Gly Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met 
     450                455                460
Gln Val Val Leu Ser Arg Thr Ala His Phe Thr Pro His Val Asn Phe 
 465                470                475                480
Leu Leu Asp Ser Tyr Pro Val Ser Pro Glu Val Ile Val Glu His Pro 
                 485                490                495
Ser Asn Gln Asn Gly Tyr Thr Leu Val Val Thr Gly Lys Lys Ile Thr 
             500                505                510
Lys Ile Pro Leu Asn Gly Leu Gly Cys Gly His Phe Gln Ser Cys Ser 
         515                520                525
Gln Cys Leu Ser Pro Pro Tyr Phe Ile Gln Cys Gly Trp Cys His Asn 
     530                535                540
Arg Cys Val His Ser Asn Glu Cys Pro Ser Gly Thr Trp Thr Gln Glu 
 545                550                555                560
Ile Cys Leu Pro Ala Val Tyr Lys Val Phe Pro Thr Ser Ala Pro Leu 
                 565                570                575
Glu Gly Gly Thr Met Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Lys 
             580                585                590
Lys Asn Asn Lys Phe Asp Leu Arg Lys Thr Lys Val Leu Leu Gly Asn 
         595                600                605
Glu Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Thr Asn Thr Leu Lys 
     610                615                620
Cys Thr Val Gly Pro Ala Met Ser Glu His Phe Asn Val Ser Val Ile 
 625                630                635                640
Val Ser Asn Ser Arg Glu Thr Thr Gln Tyr Ser Ala Phe Ser Tyr Val 
                 645                650                655
Asp Pro Val Ile Thr Ser Ile Ser Pro Arg Tyr Gly Pro His Ala Gly 
             660                665                670
Gly Thr Leu Leu Thr Leu Thr Gly Lys Tyr Leu Asn Ser Gly Asn Ser 
         675                680                685
Arg His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser 
     690                695                700
Asp Ser Ile Leu Glu Cys Tyr Thr Pro Gly His Thr Val Ser Ala Glu 
 705                710                715                720
Phe Pro Val Lys Leu Lys Ile Asp Leu Ala Asp Arg Val Thr Ser Ser 
                 725                730                735
Phe Ser Tyr Arg Glu Asp Pro Val Val Ser Glu Ile His Pro Thr Lys 
             740                745                750
Ser Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Ile Gly Lys Asn Leu 
         755                760                765
Asn Ser Val Ser Thr Pro Lys Leu Val Ile Glu Val His Asp Val Gly 
     770                775                780
Val Asn Tyr Thr Val Ala Cys Gln His Arg Ser Ser Ser Glu Ile Ile 
 785                790                795                800
Cys Cys Thr Thr Pro Ser Leu Arg Gln Leu Asp Leu Gln Leu Pro Leu 
                 805                810                815
Lys Thr Lys Ala Phe Phe Leu Leu Asp Gly Ile Leu Ser Lys His Phe 
             820                825                830
Asp Leu Thr Tyr Val His Asp Pro Met Phe Lys Pro Phe Glu Lys Pro 
         835                840                845
Val Met Ile Ser Met Gly Asn Glu Asn Val Val Glu Ile Lys Gly Asp 
     850                855                860
Asp Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn 
 865                870                875                880
Lys Ser Cys Glu Asn Leu His Trp His Ser Glu Ala Leu Leu Cys Thr 
                 885                890                895
Val Pro Ser Asp Leu Leu Lys Leu Asn Gly Gly Glu Leu Asn Ile Glu 
             900                905                910
Trp Lys Gln Ala Val Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln 
         915                920                925
Pro Asp Gln Asn Phe Ala Gly Leu Ile Ile Gly Ala Val Ser Ile Ser 
     930                935                940
Val Val Val Leu Leu Val Ser Gly Leu Phe Leu Trp Leu Arg Lys Arg 
 945                950                955                960
Lys His Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val 
                 965                970                975
His Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro 
             980                985                990
Thr Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr Phe 
         995                1000                1005
Pro Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn Gly Ala Cys Arg Gln 
     1010                1015                1020
Val Gln Tyr Leu Leu Thr Asp Leu Ser Pro Ile Leu Thr Ser Gly Asp 
 1025                1030                1035                1040
Ser Asp Ile Ser Ser Pro Leu Leu Gln Asn Thr Val His Ile Asp Leu 
                 1045                1050                1055
Ser Ala Leu Asn Pro Glu Leu Val Gln Ala Val Pro His Val Val Ile 
             1060                1065                1070
Gly Pro Ser Ser Leu Ile Val His Phe Asn Glu Val Ile Gly Arg Gly 
         1075                1080                1085
His Phe Gly Cys Val Tyr His Gly Thr Leu Leu Asp Ser Asp Gly Lys 
     1090                1095                1100
Lys Ile His Cys Ala Val Lys Ser Leu Asn Arg Ile Thr Asp Ile Glu 
 1105                1110                1115                1120
Glu Val Ser Gln Phe Leu Thr Glu Gly Ile Ile Met Lys Asp Phe Ser 
                 1125                1130                1135
His Pro Asn Val Leu Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu Gly 
             1140                1145                1150
Ser Pro Leu Val Val Leu Pro Tyr Met Lys His Gly Asp Leu Arg Asn 
         1155                1160                1165
Phe Ile Arg Asn Glu Thr His Asn Pro Thr Val Lys Asp Leu Ile Gly 
     1170                1175                1180
Phe Gly Leu Gln Val Ala Lys Gly Met Lys Tyr Leu Val Ser Lys Lys 
 1185                1190                1195                1200
Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu Lys 
                 1205                1210                1215
Phe Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr Asp 
             1220                1225                1230
Lys Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala Lys Leu Pro Val 
         1235                1240                1245
Lys Trp Met Ala Leu Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr Lys 
     1250                1255                1260
Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Leu Met Thr Arg 
 1265                1270                1275                1280
Gly Ala Pro Pro Tyr Pro Asp Val Asn Thr Phe Asp Ile Thr Ile Tyr 
                 1285                1290                1295
Leu Leu Gln Gly Arg Arg Leu Leu Gln Pro Glu Tyr Cys Pro Asp Ala 
             1300                1305                1310
Leu Tyr Glu Val Met Leu Lys Cys Trp His Pro Lys Ala Glu Met Arg 
         1315                1320                1325
Pro Ser Val Ser Glu Leu Val Ser Arg Ile Ser Ser Ile Phe Ser Thr 
     1330                1335                1340
Phe Ile Gly Glu His Tyr Val His Val Asn Ala Thr Tyr Val Asn Val 
 1345                1350                1355                1360
Lys Cys Val Ala Pro Tyr Pro Ser Leu Leu Pro Ser Gln Asp Asn Ile 
                 1365                1370                1375
Asp Gly Glu Ala Asn Thr 
             1380



<210> 8780
<211> 432
<212> DNA
<213> Homo sapiens
<308> U11813
<400> 8780

tggtccttt  gcgtcgtcc  ctgggagct  atgacaaga  gagccccac  ttatcctga  60
gtaaacacc  ttgatataa  tgtttactt  ttgcaaggg  gaagactcc  acaacccga  120
tactgccca  accccttgt  agtagtctt  ctgcacctc  tacgttctt  acttttaca  180
aaatgcctg  cttcaaagg  tcttcttac  gcatgtctt  ctttttgga  cagatatga  240
gtaatgcta  aatgctggc  ccctaaagc  gaaatgcgc  catcctttt  tgaactggt  300
tcccggata  cagcaatct  ctctacttt  attggggag  actatgtcc  tgtgaacgc  360
acttatgtg  acgtaaaat  tgtcgctcc  tatccttct  tgttgtcat  agaagataa  420
gctgatgat  ag  432



<210> 8781
<211> 1390
<212> PRT
<213> Homo sapiens
<308> P08581
<400> 8781

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
  1               5                  10                  15
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
             20                  25                  30
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
         35                  40                  45
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
     50                  55                  60
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
 65                  70                  75                  80
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                 85                  90                  95
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
             100                105                110
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
         115                120                125
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
     130                135                140
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
 145                150                155                160
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                 165                170                175
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
             180                185                190
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
         195                200                205
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
     210                215                220
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
 225                230                235                240
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                 245                250                255
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
             260                265                270
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
         275                280                285
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
     290                295                300
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
 305                310                315                320
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                 325                330                335
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
             340                345                350
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
         355                360                365
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
     370                375                380
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
 385                390                395                400
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                 405                410                415
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
             420                425                430
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
         435                440                445
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
     450                455                460
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
 465                470                475                480
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                 485                490                495
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
             500                505                510
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
         515                520                525
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
     530                535                540
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
 545                550                555                560
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                 565                570                575
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
             580                585                590
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
         595                600                605
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
     610                615                620
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
 625                630                635                640
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                 645                650                655
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
             660                665                670
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
         675                680                685
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
     690                695                700
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
 705                710                715                720
Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                 725                730                735
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
             740                745                750
Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
         755                760                765
Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
     770                775                780
Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
 785                790                795                800
Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                 805                810                815
Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
             820                825                830
Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
         835                840                845
Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
     850                855                860
Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
 865                870                875                880
Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                 885                890                895
Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
             900                905                910
Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
         915                920                925
Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
     930                935                940
Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
 945                950                955                960
Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                 965                970                975
Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
             980                985                990
Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr Phe Pro 
         995                1000                1005
Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg Gln Val 
     1010                1015                1020
Gln Tyr Pro Leu Thr Asp Met Ser Pro Ile Leu Thr Ser Gly Asp Ser 
 1025                1030                1035                1040
Asp Ile Ser Ser Pro Leu Leu Gln Asn Thr Val His Ile Asp Leu Ser 
                 1045                1050                1055
Ala Leu Asn Pro Glu Leu Val Gln Ala Val Gln His Val Val Ile Gly 
             1060                1065                1070
Pro Ser Ser Leu Ile Val His Phe Asn Glu Val Ile Gly Arg Gly His 
         1075                1080                1085
Phe Gly Cys Val Tyr His Gly Thr Leu Leu Asp Asn Asp Gly Lys Lys 
     1090                1095                1100
Ile His Cys Ala Val Lys Ser Leu Asn Arg Ile Thr Asp Ile Gly Glu 
 1105                1110                1115                1120
Val Ser Gln Phe Leu Thr Glu Gly Ile Ile Met Lys Asp Phe Ser His 
                 1125                1130                1135
Pro Asn Val Leu Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu Gly Ser 
             1140                1145                1150
Pro Leu Val Val Leu Pro Tyr Met Lys His Gly Asp Leu Arg Asn Phe 
         1155                1160                1165
Ile Arg Asn Glu Thr His Asn Pro Thr Val Lys Asp Leu Ile Gly Phe 
     1170                1175                1180
Gly Leu Gln Val Ala Lys Gly Met Lys Tyr Leu Ala Ser Lys Lys Phe 
 1185                1190                1195                1200
Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu Lys Phe 
                 1205                1210                1215
Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr Asp Lys 
             1220                1225                1230
Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala Lys Leu Pro Val Lys 
         1235                1240                1245
Trp Met Ala Leu Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr Lys Ser 
     1250                1255                1260
Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Leu Met Thr Arg Gly 
 1265                1270                1275                1280
Ala Pro Pro Tyr Pro Asp Val Asn Thr Phe Asp Ile Thr Val Tyr Leu 
                 1285                1290                1295
Leu Gln Gly Arg Arg Leu Leu Gln Pro Glu Tyr Cys Pro Asp Pro Leu 
             1300                1305                1310
Tyr Glu Val Met Leu Lys Cys Trp His Pro Lys Ala Glu Met Arg Pro 
         1315                1320                1325
Ser Phe Ser Glu Leu Val Ser Arg Ile Ser Ala Ile Phe Ser Thr Phe 
     1330                1335                1340
Ile Gly Glu His Tyr Val His Val Asn Ala Thr Tyr Val Asn Val Lys 
 1345                1350                1355                1360
Cys Val Ala Pro Tyr Pro Ser Leu Leu Ser Ser Glu Asp Asn Ala Asp 
                 1365                1370                1375
Asp Glu Val Asp Thr Arg Pro Ala Ser Phe Trp Glu Thr Ser 
             1380                1385                1390



<210> 8782
<211> 620
<212> DNA
<213> Rattus norvegicus
<308> U65217
<400> 8782

gcggtgacc  agctggggc  gccctcagc  gagtacttt  acaagcagt  cctggagcg  60
acgcgggcc  agctggaca  ggtctgcag  cacaactac  agaagacag  ggtccccac  120
tccctgcgg  ggcttgagc  gcccaatgt  gccatctcc  tgtccagga  agaggccct  180
aaccaccac  acttgctgg  ctgctcagt  acagatttc  acccagccc  gatcaaagt  240
cgctggttc  ggaatggcc  ggaggagat  gcgggggtc  tgtccacac  gcttattag  300
aacggggac  ggacctttc  gatcctggt  atgctggag  tgacgcctc  gcggggaga  360
gtgtacacc  gccgtgttg  ccaccccag  ctcgatagc  ctgtcacag  ggagtggcg  420
gcacagtcc  agtctgccc  gagcaagat  ctgagtggc  tcgggggcc  tgtgctggg  480
gtgatcttc  ttgggcttg  ccttttcat  cattataag  gtcagaaag  acctcaggg  540
cctcctcca  caaggtctc  tacagtgac  cagagtgtt  tgagtgagt  gactgtctc  600
cacggtcag  ccctgaaaat  620



<210> 8783
<211> 196
<212> PRT
<213> Rattus norvegicus
<308> AAB39559
<400> 8783

Ala Val Thr Glu Leu Gly Arg Pro Ser Ala Glu Tyr Phe Asn Lys Gln 
  1               5                  10                  15
Tyr Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg His Asn 
             20                  25                  30
Tyr Glu Lys Thr Glu Val Pro Thr Ser Leu Arg Arg Leu Glu Gln Pro 
         35                  40                  45
Asn Val Ala Ile Ser Leu Ser Arg Thr Glu Ala Leu Asn His His Asn 
     50                  55                  60
Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val 
 65                  70                  75                  80
Arg Trp Phe Arg Asn Gly Gln Glu Glu Met Ala Gly Val Val Ser Thr 
                 85                  90                  95
Gln Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu 
             100                105                110
Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys Arg Val Asp His 
         115                120                125
Pro Ser Leu Asp Ser Pro Val Thr Val Glu Trp Arg Ala Gln Ser Glu 
     130                135                140
Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Leu Val Leu Gly 
 145                150                155                160
Val Ile Phe Leu Gly Leu Gly Leu Phe Ile His Tyr Lys Ser Gln Lys 
                 165                170                175
Gly Pro Gln Gly Pro Pro Pro Ala Arg Ser Pro Thr Val Thr Gln Ser 
             180                185                190
Val Leu Ser Glu 
         195



<210> 8784
<211> 1763
<212> DNA
<213> Homo sapiens
<308> M16276
<400> 8784

gcactggac  gagaacctt  accaaaaaa  tgtctgccc  gagacagat  aggtccttc  60
gctccagtg  tgattggtt  ttttccaaa  gcccatcta  tcctaccac  cacggaaat  120
tccacaggt  tttattctt  ctgccagct  catcagatc  atcaggtcc  agctgagtt  180
actaccact  cttttccct  tgtctcaat  atgtcttgg  agaaggctt  gcggatccc  240
ggaggcctt  gggcaccaa  tgtgacctt  atgctggcg  tgctgagca  cccagtggc  300
gagggcaga  accctcccg  ggatttcgt  ctccagttt  aggccatgt  ctacttcac  360
aatgggacg  agcgcgtgc  ttatgtgac  agatacatc  ataaccgag  ggaggacgt  420
cgcttcgac  gcgacgtgg  ggtgtatcg  gcggtgacg  cgcaggggc  gcctgacgc  480
gagtactgg  acagccaga  ggacatcct  gagaggacc  gagcggagt  ggacacggt  540
tgcagacac  actacgagg  ggcgttccg  gggatcttg  agaggagag  ggagcccac  600
gtgaccatc  ccccatcca  gacagaggc  ctcaaccac  acaacctgc  ggtctgctc  660
gtgacagat  tctatccag  ccagatcaa  gtccggtgg  ttcggaatg  ccaggagga  720
acagctggc  ttgtgtcca  cccccttat  aggaacggt  actggacct  ccagatcct  780
gtgatgctg  aaatgactc  ccagcatgg  gacgtctac  cctgccacg  ggagcaccc  840
agcctccag  gccccatca  cgtggagtg  cgggctcag  ctgaatctg  ccagaacaa  900
atgctgagt  gcattggag  cttcgtgct  gggctgatc  tcctcgggc  gggccttat  960
atccgtcaa  ggagtcaga  aggacctca  gggcctcca  cagcagggc  tctgcactg  1020
ctcctgaga  tattttaac  aggattggt  atcactctt  tgtgatgcc  gcttgtgcc  1080
gcccagaat  cccagctgc  tgtgtcagc  tgtcccccg  gatcaaagt  ctacagtgg  1140
tgtcacgca  ccaccaggt  atctccttt  atccccacc  caaggcgct  gctgtgact  1200
tgcttcctg  actgaccca  agcctctgc  tgtgcacgg  cagctgcgt  tactcaggt  1260
ccaaggggt  tctgtttct  ttctctcct  agactgctc  agagaagca  atgaaaaac  1320
ttacctgac  ttagagctt  tttacataa  taaacatga  cctgagtta  aaaaaaaaa  1380
ggaaatcgc  gcagaatga  ggaatatcc  ttgaggtga  ccagccaac  tgtggccag  1440
aggagggtt  taccttgaa  agaccactg  aagcatttt  gggtgtcaa  taagggtgg  1500
cagaggagg  agaaaatca  ttcaattgt  gcatcattc  tggttcttt  atattgatg  1560
tcagtgcat  ggccttaga  tatcccagc  tctcttctg  tttggtgag  gctgtgtaa  1620
taagcatgg  agaattgtt  ggagacata  atagtgatc  ttggtcact  gtgtttcaa  1680
cattctgga  agtcacatc  atcaagaat  ttttttatt  ttaagaaag  ataaccagc  1740
ataaaaata  tatttttga  tct  1763



<210> 8785
<211> 261
<212> PRT
<213> Homo sapiens
<308> P01919
<400> 8785

Met Ser Trp Lys Lys Ser Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
  1               5                  10                  15
Thr Val Thr Leu Met Leu Ala Ile Leu Ser Ser Ser Leu Ala Glu Gly 
             20                  25                  30
Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Leu Cys Tyr 
         35                  40                  45
Phe Thr Asn Gly Thr Glu Arg Val Arg Gly Val Thr Arg His Ile Tyr 
     50                  55                  60
Asn Arg Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
 65                  70                  75                  80
Ala Val Thr Pro Gln Gly Arg Pro Val Ala Glu Tyr Trp Asn Ser Gln 
                 85                  90                  95
Lys Glu Val Leu Glu Gly Ala Arg Ala Ser Val Asp Arg Val Cys Arg 
             100                105                110
His Asn Tyr Glu Val Ala Tyr Arg Gly Ile Leu Gln Arg Arg Val Glu 
         115                120                125
Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
     130                135                140
Asn Leu Leu Ile Cys Ser Val Thr Asp Phe Tyr Pro Ser Gln Ile Lys 
 145                150                155                160
Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                 165                170                175
Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
             180                185                190
Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
         195                200                205
His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
     210                215                220
Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu 
 225                230                235                240
Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Arg 
                 245                250                255
Lys Gly Leu Leu His 
             260



<210> 8786
<211> 1058
<212> DNA
<213> Rattus norvegicus
<308> U65417
<400> 8786

tggaattaa  tgaggagca  agctggatg  gcaacagga  agaccttca  tacgagctg  60
accccggag  ggtggccac  gccagcatt  tctttggcg  tttgtggtt  ttctctatc  120
ttggcaatt  ccttgtgtg  ctggtcatc  ataggagcc  gaggactca  tccaccacc  180
actaccttg  ggtctccat  gcgtgtgct  accttctca  cagtgtggc  agcacaccg  240
ttgtcgtgc  gcagttcac  accgggagg  ggaccctcg  gagcgccat  tgcaaggtg  300
tccgctact  ccagtatct  accccaggc  tccagatct  cgtgctgct  tccatctgc  360
tagaccgct  ctacaccat  gtctaccct  tgagcttca  ggtgtccag  gaaaaggcc  420
agagaatga  cgcagcctc  tggatcttg  acgcagcct  cgtgacgcc  gtcttcttt  480
tctacggct  taactggga  agccactgt  actacttcc  cccaccctc  tgggaggga  540
ctgcctata  tgttatcca  ttcttggtg  gctttgtga  tccctctgt  ctcataatc  600
tgttttacc  gaaagtcat  aagtatatc  ggagaatag  cacggacgg  cggaccctg  660
ggaggacaa  gaacattgt  cccaggacc  aggtgaaga  ggtcaagat  tttctgctc  720
tcaaccttg  gttcctgtt  tcctggctg  ctttccatg  ggctcagct  tggcatccc  780
atgagcaag  gtacaggaa  agctccctt  ttttcacag  agtcacgtg  gtgtctttc  840
gctcttcgg  ctctaaacc  actctgtac  ctatttata  cgccaattt  cggagaggg  900
tgaaagaga  tttctgcat  tcctcaatg  aatgttacc  cagcaatgc  tacaccatc  960
cgaccagtt  aaggatggc  aaaagaaac  atgtgggca  ttcggaaat  cctcccgtg  1020
gcaggacga  aaccaaaga  tcgatctat  actcatta  1058



<210> 8787
<211> 352
<212> PRT
<213> Rattus norvegicus
<308> AAB49752
<400> 8787

Glu Leu Ser Glu Glu His Ser Trp Met Ser Asn Arg Thr Asp Leu Gln 
  1               5                  10                  15
Tyr Glu Leu Asn Pro Gly Glu Val Ala Thr Ala Ser Ile Phe Phe Gly 
             20                  25                  30
Ala Leu Trp Leu Phe Ser Ile Phe Gly Asn Ser Leu Val Cys Leu Val 
         35                  40                  45
Ile His Arg Ser Arg Arg Thr Gln Ser Thr Thr Asn Tyr Leu Val Val 
     50                  55                  60
Ser Met Ala Cys Ala Asp Leu Leu Ile Ser Val Ala Ser Thr Pro Phe 
 65                  70                  75                  80
Val Val Leu Gln Phe Thr Thr Gly Arg Trp Thr Leu Gly Ser Ala Met 
                 85                  90                  95
Cys Lys Val Val Arg Tyr Phe Gln Tyr Leu Thr Pro Gly Val Gln Ile 
             100                105                110
Tyr Val Leu Leu Ser Ile Cys Ile Asp Arg Phe Tyr Thr Ile Val Tyr 
         115                120                125
Pro Leu Ser Phe Lys Val Ser Arg Glu Lys Ala Lys Arg Met Ile Ala 
     130                135                140
Ala Ser Trp Ile Leu Asp Ala Ala Phe Val Thr Pro Val Phe Phe Phe 
 145                150                155                160
Tyr Gly Ser Asn Trp Asp Ser His Cys Asn Tyr Phe Leu Pro Pro Ser 
                 165                170                175
Trp Glu Gly Thr Ala Tyr Thr Val Ile His Phe Leu Val Gly Phe Val 
             180                185                190
Ile Pro Ser Val Leu Ile Ile Leu Phe Tyr Gln Lys Val Ile Lys Tyr 
         195                200                205
Ile Trp Arg Ile Gly Thr Asp Gly Arg Thr Leu Arg Arg Thr Met Asn 
     210                215                220
Ile Val Pro Arg Thr Lys Val Lys Thr Val Lys Met Phe Leu Leu Phe 
 225                230                235                240
Asn Leu Val Phe Leu Phe Ser Trp Leu Pro Phe His Val Ala Gln Leu 
                 245                250                255
Trp His Pro His Glu Gln Glu Tyr Arg Lys Ser Ser Leu Val Phe Thr 
             260                265                270
Ala Val Thr Trp Val Ser Phe Ser Ser Ser Ala Ser Lys Pro Thr Leu 
         275                280                285
Tyr Ser Ile Tyr Asn Ala Asn Phe Arg Arg Gly Met Lys Glu Thr Phe 
     290                295                300
Cys Met Ser Ser Met Lys Cys Tyr Arg Ser Asn Ala Tyr Thr Ile Thr 
 305                310                315                320
Thr Ser Ser Arg Met Ala Lys Arg Asn Tyr Val Gly Ile Ser Glu Ile 
                 325                330                335
Pro Pro Val Ser Arg Thr Ile Thr Lys Asp Ser Ile Tyr Asp Ser Leu 
             340                345                350



<210> 8788
<211> 1409
<212> DNA
<213> Homo sapiens
<308> NM_006143
<400> 8788

aattaagag  aaaaaagtg  atatggttt  tgctcacag  atggataac  gcaagccac  60
tttgattat  cctacactt  tggtgcccc  ccaaaaccg  agctgcact  aaacagcca  120
acctctgcc  agccaatac  tgatggaat  aagtgagga  cacagttgg  tgagcaacc  180
aacagacct  cactatgtg  tgaaacccg  ggaagtggc  acagccagc  tcttctttg  240
gattctgtg  ttgttttct  tcttcggca  ttccctggt  tgtttggtc  tccatagga  300
taggaggac  cagtctacc  ccaactact  tgtggtctc  atggcatgt  ctgaccttc  360
catcagcgt  gccagcacg  ctttcgtcc  gctccagtt  accactgga  ggtggacgc  420
gggtagtgc  acgtgcaag  ttgtgcgat  ttttcaata  ctcactcca  gtgtccaga  480
ctacgttct  ctctccatc  gcatagacc  gttctacac  atcgtctat  ctctgagct  540
caaggtgtc  agagaaaaa  ccaagaaaa  gattgcggc  tcgtggatc  ttgatgcag  600
ctttgtgac  cctgtgctc  ttttctatg  ctccaactg  gacagtcat  gtaactatt  660
cctcccctc  tcttgggaa  gcactgcct  cactgtcat  cacttcttg  tgggctttg  720
gattccatc  gtcctcata  ttttatttt  ccaaaaggt  ataaaatat  tttggagaa  780
aggcacaga  ggccgaacg  tgaggagga  aatgaacat  gtccctcgg  caaaagtga  840
aactatcaa  atgttcctc  ttttaaatc  gttgttttt  ctctcctgg  tgccttttc  900
tgtagctca  ctatggcac  cccatgaac  agactataa  aaaagttcc  ttgttttca  960
agctatcac  tggatatcc  ttagttctt  agcctctaa  cctactctg  attcaattt  1020
taatgccaa  tttcggaga  ggatgaaag  gactttttg  atgtcctct  tgaaatgtt  1080
ccgaagcaa  gcctatact  tcacaacaa  ttcaaggat  gccaaaaaa  actacgttg  1140
catttcaga  atcccttcc  tggccaaaa  tattaccaa  gactcgatc  atgactcat  1200
tgacagaga  gccaaggaa  aaaagcttg  ttggcccat  aactcaaat  caccaaata  1260
ttttgtcta  gttctcatt  tttcaattg  tatgcacca  agattaaaa  gctttaact  1320
taaaaacag  agctattta  atatttgtt  tcactcaac  ttccaaggg  aatgtttta  1380
tttgtaaaa  gcattcatt  gtttactgt  1409



<210> 8789
<211> 415
<212> PRT
<213> Homo sapiens
<308> NP_006134
<400> 8789

Met Val Phe Ala His Arg Met Asp Asn Ser Lys Pro His Leu Ile Ile 
  1               5                  10                  15
Pro Thr Leu Leu Val Pro Leu Gln Asn Arg Ser Cys Thr Glu Thr Ala 
             20                  25                  30
Thr Pro Leu Pro Ser Gln Tyr Leu Met Glu Leu Ser Glu Glu His Ser 
         35                  40                  45
Trp Met Ser Asn Gln Thr Asp Leu His Tyr Val Leu Lys Pro Gly Glu 
     50                  55                  60
Val Ala Thr Ala Ser Ile Phe Phe Gly Ile Leu Trp Leu Phe Ser Ile 
 65                  70                  75                  80
Phe Gly Asn Ser Leu Val Cys Leu Val Ile His Arg Ser Arg Arg Thr 
                 85                  90                  95
Gln Ser Thr Thr Asn Tyr Phe Val Val Ser Met Ala Cys Ala Asp Leu 
             100                105                110
Leu Ile Ser Val Ala Ser Thr Pro Phe Val Leu Leu Gln Phe Thr Thr 
         115                120                125
Gly Arg Trp Thr Leu Gly Ser Ala Thr Cys Lys Val Val Arg Tyr Phe 
     130                135                140
Gln Tyr Leu Thr Pro Gly Val Gln Ile Tyr Val Leu Leu Ser Ile Cys 
 145                150                155                160
Ile Asp Arg Phe Tyr Thr Ile Val Tyr Pro Leu Ser Phe Lys Val Ser 
                 165                170                175
Arg Glu Lys Ala Lys Lys Met Ile Ala Ala Ser Trp Ile Phe Asp Ala 
             180                185                190
Gly Phe Val Thr Pro Val Leu Phe Phe Tyr Gly Ser Asn Trp Asp Ser 
         195                200                205
His Cys Asn Tyr Phe Leu Pro Ser Ser Trp Glu Gly Thr Ala Tyr Thr 
     210                215                220
Val Ile His Phe Leu Val Gly Phe Val Ile Pro Ser Val Leu Ile Ile 
 225                230                235                240
Leu Phe Tyr Gln Lys Val Ile Lys Tyr Ile Trp Arg Ile Gly Thr Asp 
                 245                250                255
Gly Arg Thr Val Arg Arg Thr Met Asn Ile Val Pro Arg Thr Lys Val 
             260                265                270
Lys Thr Ile Lys Met Phe Leu Ile Leu Asn Leu Leu Phe Leu Leu Ser 
         275                280                285
Trp Leu Pro Phe His Val Ala Gln Leu Trp His Pro His Glu Gln Asp 
     290                295                300
Tyr Lys Lys Ser Ser Leu Val Phe Thr Ala Ile Thr Trp Ile Ser Phe 
 305                310                315                320
Ser Ser Ser Ala Ser Lys Pro Thr Leu Tyr Ser Ile Tyr Asn Ala Asn 
                 325                330                335
Phe Arg Arg Gly Met Lys Glu Thr Phe Cys Met Ser Ser Met Lys Cys 
             340                345                350
Tyr Arg Ser Asn Ala Tyr Thr Ile Thr Thr Ser Ser Arg Met Ala Lys 
         355                360                365
Lys Asn Tyr Val Gly Ile Ser Glu Ile Pro Ser Met Ala Lys Thr Ile 
     370                375                380
Thr Lys Asp Ser Ile Tyr Asp Ser Phe Asp Arg Glu Ala Lys Glu Lys 
 385                390                395                400
Lys Leu Ala Trp Pro Ile Asn Ser Asn Pro Pro Asn Thr Phe Val 
                 405                410                415



<210> 8790
<211> 3053
<212> DNA
<213> Rattus norvegicus
<308> U65656
<400> 8790

ctggcgtct  cccgccctt  tttccgctg  atccagact  ccccgggtg  ctggaggct  60
tgtgtgcat  cagaacttt  gatatacaa  gggattact  ggacctgca  gcacccgca  120
ccgtggtgc  tactggtac  tgggatccc  ttatgagac  ctgagcccg  agaagctga  180
gcaattgag  aaaggggtc  cagaacgcc  tggagagca  gcgccagcc  ggtggaccc  240
agggcacag  cagcgacct  agggtgaca  gcggagccc  ggagcgcaa  gatggaggc  300
cgattggtc  ggggagtgc  cgtcggccc  ctgcgggtt  tctgcgtcc  gtgctgcct  360
ctgggccac  ccatcgctg  accgtcgcc  atcatcaag  tccccggcg  tgtctcccc  420
aaaacagac  aagagttgg  agtgcaata  ctgaacact  tctatggct  ccccaagga  480
agttgcaac  tctttgtgc  gaaggacac  ctcaagaag  tgcagaagt  ctttgggct  540
ccccagaca  gtgaccttg  ccagaacac  atcgagacc  tgcggaaac  aagatgtgg  600
aacccagat  tggccaact  caacttctt  ccccgcaag  ccaagtggg  caagaatca  660
atcacatac  ggatcattg  ttacacacc  gacctggac  ctgagacag  ggatgatgc  720
tttgctcgg  ccttaaaag  atggagcga  gtaactcca  tacgctttt  tcgaatcca  780
gatggggaa  ctgacatca  gatcaactt  ggtcgatgg  agcatggag  tggataccc  840
tttgacggc  aggacggac  cctggcaca  gcctttgcc  cgggcactg  tgttggggg  900
gattctcac  ttgatgacg  tgagctgtg  actctagga  aaggacaag  ggtccgagt  960
aagtatggg  acgctgatg  cgagtactg  aagttcccc  tcttgttta  tggtcggga  1020
tacagcagc  gcacagaca  tggccggag  gacggcttc  tctggtgtt  caccacgta  1080
aactttgag  aggacggca  atatggctt  tgtccccac  aagccttgt  taccatggg  1140
ggcaatgga  atggacagc  ctgcaagtt  ccgttccgc  tccagggca  ctcttacaa  1200
agctgtacc  ccgagggcc  tacagacgg  taccgctgg  gtggcacca  cgaggatta  1260
gaccgggat  agaagtatg  attctgccc  gagactgct  tgtccactg  gggtggaaa  1320
tcagaaggt  ccccatgtg  cttcccctt  acttttctg  gcaacaagt  tgagagctg  1380
accagcgct  gccgaagcg  tggcaaggt  tggtgtgca  ccacaacca  ctacgatga  1440
gaccggaag  ggggcttct  tcccgacca  ggatatagc  tattccttg  ggcagccca  1500
gagttcggc  atgccatgg  gctggaaca  tcacaggac  ctggagctt  gatggcccc  1560
atctacacc  acaccaaga  cttccgact  tccaatgat  acatcaagg  gatccagga  1620
ctctatggg  cctcccctg  tgctgatac  gacactggt  ctggaccca  gcctacact  1680
ggacctgtc  ctcccgaga  ctgcaagca  gacattgtc  ttgatggca  tgctcagat  1740
cgtggtgag  tcttcttct  caaggatcg  tttatttgg  ggacagtga  accacgtga  1800
aagcccaca  gtcccttgc  ggtggccac  ttctggcct  agctcccgg  aaagattga  1860
gccgtgtac  aggccccac  ggaagagaa  gctgtgttc  tcgcaggga  tgagtactg  1920
gtctattct  ccagcactt  ggaaagagg  taccccaag  cactgacca  cctgggttt  1980
ccccctgat  tccagcaag  agacgctgc  tttaactgg  gtaagaaca  gaagacata  2040
atcttttct  gggacaagt  ctggagata  aatgaagta  agaagaaaa  ggaccccgg  2100
ttcccgaag  tcatcgcag  ctcctggaa  gccatccct  ataacctgg  tgcagtcgt  2160
gacctgcag  gtggtggtc  cagctattt  ttcaagggt  cttattacc  gaagttgga  2220
aaccaaagt  tgaagagtg  gaagtttgg  agcatcaaa  cggactggc  gggctgctg  2280
gctggccct  ttctgacgg  ccgtacaat  ttcactgca  accgggccc  ggaccctgg  2340
gaaggacgt  aagaggcct  gttaccctg  ctcctgctc  gtagttaat  agccttctc  2400
ttcacctgg  gatttcaga  ttaagaggg  ggcttcttt  ttgtgccca  agaaaggtg  2460
tgaccgtat  cctcccagg  gctactttc  cccgcccac  caaggggat  cttggatat  2520
cacaatgca  ccctccttt  ggctgccct  gtgctccac  cttcaggtt  tccagcatg  2580
atgatcttt  gtgggttac  gcacactca  agtcaacag  gactgtctt  ggagggcac  2640
ggtggctca  cagcctggc  cagggcagt  ggatacagg  gtgccaagg  ggaaaccag  2700
gacatctgg  gtctccctt  cggctgccc  ggcactttt  ctactttag  tgtttgctt  2760
gtttgccct  tgctgtttg  ttcaacctt  tcagttttc  accacactg  atttttctc  2820
ccgaaggac  ccggttgtc  gacatcact  cacgatgca  ctggcctgg  ctatggatg  2880
ctcccctcc  cactttgtg  agaagcaac  ccagtcact  cctccactg  ttggaggag  2940
accaagtca  cggcttcct  ctcagcctt  ttgcttctc  ctttaacag  tccccatgg  3000
aaatggcaa  aagtataaa  aaaggcacc  tttgagtgg  aaaaaaaaa  aaa  3053



<210> 8791
<211> 662
<212> PRT
<213> Rattus norvegicus
<308> P33436
<400> 8791

Met Glu Ala Arg Leu Val Trp Gly Val Leu Val Gly Pro Leu Arg Val 
  1               5                  10                  15
Leu Cys Val Leu Cys Cys Leu Leu Gly His Ala Ile Ala Ala Pro Ser 
             20                  25                  30
Pro Ile Ile Lys Phe Pro Gly Asp Val Ala Pro Lys Thr Asp Lys Glu 
         35                  40                  45
Leu Ala Val Gln Tyr Leu Asn Thr Phe Tyr Gly Cys Pro Lys Glu Ser 
     50                  55                  60
Cys Asn Leu Phe Val Leu Lys Asp Thr Leu Lys Lys Met Gln Lys Phe 
 65                  70                  75                  80
Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn Thr Ile Glu Thr 
                 85                  90                  95
Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala Asn Tyr Asn Phe 
             100                105                110
Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr Tyr Arg Ile 
         115                120                125
Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala Phe 
     130                135                140
Ala Arg Ala Leu Lys Val Trp Ser Asp Val Thr Pro Leu Arg Phe Ser 
 145                150                155                160
Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn Phe Gly Arg Trp 
                 165                170                175
Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala 
             180                185                190
His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp Ser His Phe Asp 
         195                200                205
Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val Val Arg Val Lys 
     210                215                220
Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn 
 225                230                235                240
Gly Arg Glu Tyr Ser Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe 
                 245                250                255
Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly 
             260                265                270
Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn Ala Asp Gly 
         275                280                285
Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asn Ser 
     290                295                300
Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr 
 305                310                315                320
Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala 
                 325                330                335
Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro 
             340                345                350
Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg 
         355                360                365
Asn Asp Gly Lys Val Trp Cys Ala Thr Thr Thr Asn Tyr Asp Asp Asp 
     370                375                380
Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val 
 385                390                395                400
Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu His Ser Gln Asp 
                 405                410                415
Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr Lys Asn Phe Arg 
             420                425                430
Leu Ser His Asp Asp Ile Lys Gly Ile Gln Glu Leu Tyr Gly Pro Ser 
         435                440                445
Pro Asp Ala Asp Thr Asp Thr Gly Thr Gly Pro Thr Pro Thr Leu Gly 
     450                455                460
Pro Val Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp Gly Ile 
 465                470                475                480
Ala Gln Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe Ile Trp 
                 485                490                495
Arg Thr Val Thr Pro Arg Asp Lys Pro Thr Gly Pro Leu Leu Val Ala 
             500                505                510
Thr Phe Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr Glu Ala 
         515                520                525
Pro Gln Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr Trp Val 
     530                535                540
Tyr Ser Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu Thr Ser 
 545                550                555                560
Leu Gly Leu Pro Pro Asp Val Gln Gln Val Asp Ala Ala Phe Asn Trp 
                 565                570                575
Ser Lys Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe Trp Arg 
             580                585                590
Tyr Asn Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys Leu Ile 
         595                600                605
Ala Asp Ser Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val Val Asp 
     610                615                620
Leu Gln Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr Tyr Leu 
 625                630                635                640
Lys Leu Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile Lys 
                 645                650                655
Ser Asp Trp Leu Gly Cys 
             660



<210> 8792
<211> 758
<212> DNA
<213> Homo sapiens
<308> AU123141
<400> 8792

ttgtagaga  cctggccag  atacaaaga  acagacctg  taatacttt  tcaaggacg  60
ttactttgc  aaaaaaaat  aagaaagaa  acaaaataa  gtggaagct  aattaagag  120
taaacagga  caagaagca  aacaaaagt  agaagaaga  gctatctgg  gctttaaac  180
tacaaaggg  ttgccagga  ccgccgcgc  gtcgcccat  atcaagttc  ccggcgatg  240
cgcccccaa  acggacaaa  agttggcag  gcaatacct  aacaccttc  atggctgcc  300
caaggagag  tgcaacctg  ttgtgctga  ggacacact  aagaagatg  agaagttct  360
tggactgcc  cagacaggt  atcttgacc  gaataccat  gaagaccat  cggaaagcc  420
cgctgcggc  acccagatg  ggccaacta  aacttcttc  ctcgcaagc  caagtggga  480
aagaaccag  tcacataca  ggatcattg  ctacacacc  gatctggac  cagaagaca  540
tggatgatg  ctttgctcg  gccttccaa  tctggnagc  atgttgacc  ccactgcgg  600
tttctcgaa  cccattgat  ggagaggca  gacattcat  gatcaactt  ttgggccgc  660
tggggaagc  ttgggcgaa  ggggaatac  cccttttgn  acnggttaa  ggaaccggg  720
acttccctg  ggcttcatt  gcctttccg  ccccaagg  758



<210> 8793
<211> 408
<212> PRT
<213> Homo sapiens
<308> P05455
<400> 8793

Met Ala Glu Asn Gly Asp Asn Glu Lys Met Ala Ala Leu Glu Ala Lys 
  1               5                  10                  15
Ile Cys His Gln Ile Glu Tyr Tyr Phe Gly Asp Phe Asn Leu Pro Arg 
             20                  25                  30
Asp Lys Phe Leu Lys Glu Gln Ile Lys Leu Asp Glu Gly Trp Val Pro 
         35                  40                  45
Leu Glu Ile Met Ile Lys Phe Asn Arg Leu Asn Arg Leu Thr Thr Asp 
     50                  55                  60
Phe Asn Val Ile Val Glu Ala Leu Ser Lys Ser Lys Ala Glu Leu Met 
 65                  70                  75                  80
Glu Ile Ser Glu Asp Lys Thr Lys Ile Arg Arg Ser Pro Ser Lys Pro 
                 85                  90                  95
Leu Pro Glu Val Thr Asp Glu Tyr Lys Asn Asp Val Lys Asn Arg Ser 
             100                105                110
Val Tyr Ile Lys Gly Phe Pro Thr Asp Ala Thr Leu Asp Asp Ile Lys 
         115                120                125
Glu Trp Leu Glu Asp Lys Gly Gln Val Leu Asn Ile Gln Met Arg Arg 
     130                135                140
Thr Leu His Lys Ala Phe Lys Gly Ser Ile Phe Val Val Phe Asp Ser 
 145                150                155                160
Ile Glu Ser Ala Lys Lys Phe Val Glu Thr Pro Gly Gln Lys Tyr Lys 
                 165                170                175
Glu Thr Asp Leu Leu Ile Leu Phe Lys Asp Asp Tyr Phe Ala Lys Lys 
             180                185                190
Asn Glu Glu Arg Lys Gln Asn Lys Val Glu Ala Lys Leu Arg Ala Lys 
         195                200                205
Gln Glu Gln Glu Ala Lys Gln Lys Leu Glu Glu Asp Ala Glu Met Lys 
     210                215                220
Ser Leu Glu Glu Lys Ile Gly Cys Leu Leu Lys Phe Ser Gly Asp Leu 
 225                230                235                240
Asp Asp Gln Thr Cys Arg Glu Asp Leu His Ile Leu Phe Ser Asn His 
                 245                250                255
Gly Glu Ile Lys Trp Ile Asp Phe Val Arg Gly Ala Lys Glu Gly Ile 
             260                265                270
Ile Leu Phe Lys Glu Lys Ala Lys Glu Ala Leu Gly Lys Ala Lys Asp 
         275                280                285
Ala Asn Asn Gly Asn Leu Gln Leu Arg Asn Lys Glu Val Thr Trp Glu 
     290                295                300
Val Leu Glu Gly Glu Val Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu 
 305                310                315                320
Asp Gln Gln Glu Ser Leu Asn Lys Trp Lys Ser Lys Gly Arg Arg Phe 
                 325                330                335
Lys Gly Lys Gly Lys Gly Asn Lys Ala Ala Gln Pro Gly Ser Gly Lys 
             340                345                350
Gly Lys Val Gln Phe Gln Gly Lys Lys Thr Lys Phe Ala Ser Asp Asp 
         355                360                365
Glu His Asp Glu His Asp Glu Asn Gly Ala Thr Gly Pro Val Lys Arg 
     370                375                380
Ala Arg Glu Glu Thr Asp Lys Glu Glu Pro Ala Ser Lys Gln Gln Lys 
 385                390                395                400
Thr Glu Asn Gly Ala Gly Asp Gln 
                 405



<210> 8794
<211> 1257
<212> DNA
<213> Rattus norvegicus
<308> U66470
<400> 8794

cacgaagcc  gagccccag  cgcgcacag  ccgccgcag  agctccggt  ttcagcagg  60
tgtcccggt  gctaatgca  atgttgatg  tgcccctat  gctgctccc  ttgggtcaa  120
ctgccccca  ggatggagt  gcaaggctg  accctgagg  acaacagca  ctcacaacc  180
accccttcc  gccaggccc  gagcagctc  gacgtctgc  ggattatct  aagggactg  240
agaagatgg  agaggaccc  gaacaaatg  accgggagc  agtcctgct  tatctcttt  300
ctcttcacg  ctttgacca  aacggacaa  tggacggcc  ggaactctt  tccatgctg  360
cagcagctc  ggcccctgg  gctgcacac  tccccatca  cccggtgat  ctggtagta  420
acatggtgc  tgagactca  gacctggat  gagacgggc  catgactcc  gcagagctc  480
tcaacttcc  aggagaagc  cccaagcgc  cagagtccc  tcccccagc  ctccaggag  540
cacaacctg  cggaagtca  ccgctttta  ccaacagtc  gctgcaatc  gaaacccag  600
aatccctgg  gactaaaga  gaaattaca  gtcaggtag  ggccaaaag  gccttggag  660
ctgaacagg  ggctggaca  cacatagag  ctaaagtag  tgctctaag  cctgaaggg  720
aggctaggg  tcaggcaga  tctgaagga  atgccccag  tccccgaga  gatgctgag  780
gacaggtgg  gagcaagga  aacgaaggg  aagccaaag  cctgccagc  gaaacacta  840
agacccaaa  cactccaaa  gtggttgag  ctcatagca  ccaactgga  aacgacgag  900
tatgagcta  acacacagg  tcatgcccc  caggatctc  gtgcagaac  gaagcatca  960
gtgtgaata  agtgggtct  gagccacct  tgacatggg  atggtggtc  aagctcgta  1020
tcccagaag  actgagagc  ccaggctag  ctaggccac  tagcaagtt  gaagccagg  1080
tgggctact  cgtgaggcc  tgtcttgag  aggggaaaa  aaacgctct  ccacgtctc  1140
tttctggcc  tcagtagga  gcaggactt  tcttcgcag  tcaggggag  ccacaagct  1200
agaggcaga  ttcaggccc  aaacaatca  taaaaaaca  aatggattt  tctccat  1257



<210> 8795
<211> 281
<212> PRT
<213> Rattus norvegicus
<308> AAC52950
<400> 8795

Met Ser Arg Trp Leu Met Gln Met Leu Met Leu Pro Leu Leu Leu Leu 
  1               5                  10                  15
Pro Leu Gly Gln Ala Ala Pro Lys Asp Gly Val Ala Arg Leu Asp Pro 
             20                  25                  30
Glu Ala Gln Gln Gln Leu Thr Thr Asn Pro Phe Gln Pro Gly Pro Glu 
         35                  40                  45
Gln Leu Arg Arg Leu Arg Asp Tyr Leu Lys Gly Leu Glu Lys Met Glu 
     50                  55                  60
Glu Asp Pro Glu Gln Met Asn Arg Glu Gln Val Leu Leu Tyr Leu Phe 
 65                  70                  75                  80
Ala Leu His Asp Phe Asp Gln Asn Gly Gln Leu Asp Gly Leu Glu Leu 
                 85                  90                  95
Leu Ser Met Leu Thr Ala Ala Leu Ala Pro Gly Ala Ala His Phe Pro 
             100                105                110
Ile Asn Pro Val Ile Leu Val Val Asp Met Val Leu Glu Thr Gln Asp 
         115                120                125
Leu Asp Gly Asp Gly Leu Met Thr Pro Ala Glu Leu Ile Asn Phe Pro 
     130                135                140
Gly Glu Ala Pro Lys Arg Ala Glu Ser Leu Pro Pro Ala Leu Gln Glu 
 145                150                155                160
Pro Gln Pro Ala Gly Ser Gln Pro Leu Leu Ala Asn Ser Pro Leu Gln 
                 165                170                175
Ser Glu Thr Gln Gln Ser Leu Gly Thr Lys Glu Glu Ile Thr Ser Gln 
             180                185                190
Val Glu Ala Lys Arg Ala Leu Glu Pro Glu Gln Glu Ala Gly His His 
         195                200                205
Ile Glu Thr Lys Val Asp Ala Leu Ser Pro Glu Gly Glu Ala Arg Gly 
     210                215                220
Gln Ala Glu Ser Glu Gly Asp Ala Pro Gly Pro Arg Glu Asp Ala Glu 
 225                230                235                240
Arg Gln Val Glu Ser Lys Asp Asn Glu Gly Glu Ala Lys Asp Leu Pro 
                 245                250                255
Ala Glu Thr Leu Glu Thr Gln Asn Thr Pro Asn Val Val Glu Ala His 
             260                265                270
Ser Ile Gln Leu Glu Asn Asp Glu Ile 
         275                280



<210> 8796
<211> 1175
<212> DNA
<213> Homo sapiens
<308> U66468
<400> 8796

gggcggcgc  cgagcagga  cgcccacgg  gctggaccc  cagagccgc  cgcccgcgc  60
gcagttcca  gaaggatgt  acctttgac  atgacagtg  taatcctgc  gctgctccc  120
acgggtcag  ctgccccaa  ggatggagt  acaaggcca  actctgaag  gcagcatca  180
ctcctgccc  accccttcc  gccaggcca  gagcagctc  gacttctgc  gagctacct  240
aagggacta  gaaggacag  agtgcaact  gagcatctg  gccgggagc  ggttctcct  300
tacctcttt  ccctccatg  ctatgacca  agtggacag  tggatggcc  ggagctgct  360
tccatgttg  cagctgctc  ggcccctgg  gctgccaac  ctcctacca  caacccggt  420
atattgata  tggacaaag  gctcgagac  caggacctg  atggggatg  gctcatgac  480
cctgctgag  tcatcaact  cccgggagt  gccctcagg  acgtggagc  cggagagcc  540
cttgctcca  ctcctcagg  gccacaagc  gttggaagg  agtccctat  agctaaaag  600
ccattaaga  aagaaacac  ggaagcccc  ggtcccaga  aagaagcaa  gggccaggt  660
gaggccaga  gggagtctt  ggatcctgt  caggagcct  ggggccagg  agaggctga  720
ggagatgtt  cagggccca  aggggaagc  gagggccag  cagaggcta  aggagatgc  780
cctgggccc  gaggggaag  tgagggcca  gcagaggct  aaggagatg  ccctgggcc  840
agaggggaa  ctgggggcc  ggcagaggc  agggagaat  gagaggagg  caaggaact  900
ccaggggaa  cactggagt  taagaacac  caaaatgac  ttgaggtgc  cattgttca  960
gtggagaat  atgagatct  gatcttaag  tacaggtac  cacagaagt  tcagtgcca  1020
aacataagc  ctgaagtgg  caggggaaa  gtacgctgg  acaaggacc  tctctgtgc  1080
ccctgtctg  tcccagtag  tatcaggtc  ttctatgca  ctcagggag  ccctaagtt  1140
aggggcaga  taccaataa  gaactgaat  aattc  1175



<210> 8797
<211> 301
<212> PRT
<213> Homo sapiens
<308> XP_002427
<400> 8797

Met Leu Pro Leu Thr Met Thr Val Leu Ile Leu Leu Leu Leu Pro Thr 
  1               5                  10                  15
Gly Gln Ala Ala Pro Lys Asp Gly Val Thr Arg Pro Asp Ser Glu Val 
             20                  25                  30
Gln His Gln Leu Leu Pro Asn Pro Phe Gln Pro Gly Gln Glu Gln Leu 
         35                  40                  45
Gly Leu Leu Gln Ser Tyr Leu Lys Gly Leu Gly Arg Thr Glu Val Gln 
     50                  55                  60
Leu Glu His Leu Ser Arg Glu Gln Val Leu Leu Tyr Leu Phe Ala Leu 
 65                  70                  75                  80
His Asp Tyr Asp Gln Ser Gly Gln Leu Asp Gly Leu Glu Leu Leu Ser 
                 85                  90                  95
Met Leu Thr Ala Ala Leu Ala Pro Gly Ala Ala Asn Ser Pro Thr Thr 
             100                105                110
Asn Pro Val Ile Leu Ile Val Asp Lys Val Leu Glu Thr Gln Asp Leu 
         115                120                125
Asn Gly Asp Gly Leu Met Thr Pro Ala Glu Leu Ile Asn Phe Pro Gly 
     130                135                140
Val Ala Leu Arg His Val Glu Pro Gly Glu Pro Leu Ala Pro Ser Pro 
 145                150                155                160
Gln Glu Pro Gln Ala Val Gly Arg Gln Ser Leu Leu Ala Lys Ser Pro 
                 165                170                175
Leu Arg Gln Glu Thr Gln Glu Ala Pro Gly Pro Arg Glu Glu Ala Lys 
             180                185                190
Gly Gln Val Glu Ala Arg Arg Glu Ser Leu Asp Pro Val Gln Glu Pro 
         195                200                205
Gly Gly Gln Ala Glu Ala Asp Gly Asp Val Pro Gly Pro Arg Gly Glu 
     210                215                220
Ala Glu Gly Gln Ala Glu Ala Lys Gly Asp Ala Pro Gly Pro Arg Gly 
 225                230                235                240
Glu Ala Gly Gly Gln Ala Glu Ala Glu Gly Asp Ala Pro Gly Pro Arg 
                 245                250                255
Gly Glu Ala Gly Gly Gln Ala Glu Ala Arg Glu Asn Gly Glu Glu Ala 
             260                265                270
Lys Glu Leu Pro Gly Glu Thr Leu Glu Ser Lys Asn Thr Gln Asn Asp 
         275                280                285
Phe Glu Val His Ile Val Gln Val Glu Asn Asp Glu Ile 
     290                295                300



<210> 8798
<211> 1265
<212> DNA
<213> Rattus norvegicus
<308> U66471
<400> 8798

cctgggcga  tgaggacct  caaagtttg  ccgctccgg  gcgccatac  agctcggtt  60
ccggccggc  ggctggtcc  ggcttagcc  ggagacccc  atggccgca  tgttcctgg  120
tacgctcta  gaatactcg  cgctcttct  catcgcggt  gtcttcacc  gcttcatcg  180
caccaccgg  ctggtatta  gatggcttg  ctgggacgt  ccagtaatt  tgagaaact  240
agaagaaac  cagttcagc  caagagctt  caagaaaca  atgagacaa  tgaagaatc  300
gttcggctt  gagatcact  actcatccg  agcttccct  gcaacaggt  taaccttga  360
gacagactg  ctggaagac  gtcgtctta  gtgctactg  gggtgcagt  ttcaaaagc  420
ctatgaagc  cttcagaag  acgtttact  cttcaggat  agcactccg  aagccttgg  480
agaggcgct  tacagtgac  atctccacc  agaacagta  tttattaaa  agcacagca  540
agaagaaat  tattgccaa  taccaagca  tactggggt  gaagacttt  gtccagtgc  600
cagatctcg  tatccgttg  tagctctgt  gaccctcgc  gatgaggat  acagggaaa  660
ttatgacat  atttccatg  tgtctgtca  tcatattcc  gataagact  acaaacttc  720
ctgcagaat  ttgtatcaa  atttaatcc  ggctcaagg  caattttat  atcttaagc  780
acttttcat  tctgcaaat  atagtgcta  tccctccag  gaccagtct  ccgcagacg  840
gagtgtgga  cacagcttg  tggagaagg  ggggctggc  ggggctgaa  tggacccgg  900
ggaggagag  agcaaagac  gtgtggtgt  ccagaacgg  ggtgtgaac  gggtgctcc  960
gccttgccg  cacgcctgc  tgtgcgaca  ctgtgtgtg  tacttcaag  agtgtccca  1020
gtgccgcca  tttgtgcag  aatcctttg  actgtgtgg  cagaaagag  cagacaagg  1080
catactaga  acttcctga  gaatcacag  cggagagtg  actttctac  caagggcag  1140
acctcgtgt  cttagagtc  atcctaaca  agtctgcag  cttacctgt  ggagagagc  1200
ctgtgtgca  tttcatact  tgtacagta  atggatgac  ggaataaag  cttctgctc  1260
gtgcg  1265



<210> 8799
<211> 332
<212> PRT
<213> Rattus norvegicus
<308> AAC52951
<400> 8799

Met Ala Ala Val Phe Leu Val Thr Leu Tyr Glu Tyr Ser Pro Leu Phe 
  1               5                  10                  15
Tyr Ile Ala Val Val Phe Thr Cys Phe Ile Ala Thr Thr Gly Leu Val 
             20                  25                  30
Leu Gly Trp Leu Gly Trp Asp Val Pro Val Ile Leu Arg Asn Ser Glu 
         35                  40                  45
Glu Thr Gln Phe Ser Thr Arg Ala Phe Lys Lys Gln Met Arg Gln Val 
     50                  55                  60
Lys Asn Pro Phe Gly Leu Glu Ile Thr Asn Ser Ser Ala Ala Ser Leu 
 65                  70                  75                  80
Ala Thr Gly Val Thr Leu Thr Thr Asp Cys Leu Glu Asp Ser Arg Leu 
                 85                  90                  95
Thr Cys Tyr Trp Gly Cys Ser Val Gln Lys Leu Tyr Glu Ala Leu Gln 
             100                105                110
Lys His Val Tyr Cys Phe Arg Ile Ser Thr Pro Gln Ala Leu Glu Glu 
         115                120                125
Ala Leu Tyr Ser Asp Tyr Leu His Arg Glu Gln Tyr Phe Ile Lys Lys 
     130                135                140
His Ser Lys Glu Glu Ile Tyr Cys Gln Leu Pro Ser Ser Thr Gly Val 
 145                150                155                160
Glu Asp Phe Gly Pro Val Pro Arg Ser Arg Tyr Pro Leu Val Ala Leu 
                 165                170                175
Leu Thr Leu Ala Asp Glu Asp Asp Arg Glu Ile Tyr Asp Ile Ile Ser 
             180                185                190
Met Val Ser Val Ile His Ile Pro Asp Lys Thr Tyr Lys Leu Pro Cys 
         195                200                205
Arg Ile Leu Tyr Gln Tyr Leu Ile Leu Ala Gln Gly Gln Phe Tyr Asp 
     210                215                220
Leu Lys Gln Leu Phe Met Ser Ala Asn Asn Ser Ala Thr Pro Ser Arg 
 225                230                235                240
Asp Gln Ser Pro Ala Asp Gly Ser Val Glu His Ser Leu Leu Glu Lys 
                 245                250                255
Ala Gly Leu Ala Gly Ala Glu Val Asp Pro Val Glu Glu Ser Ser Lys 
             260                265                270
Asp Cys Val Val Cys Gln Asn Gly Gly Val Asn Trp Val Leu Leu Pro 
         275                280                285
Cys Arg His Ala Cys Leu Cys Asp Ser Cys Val Cys Tyr Phe Lys Gln 
     290                295                300
Cys Pro Met Cys Arg Gln Phe Val Gln Glu Ser Phe Ala Leu Cys Gly 
 305                310                315                320
Gln Lys Glu Ala Asp Lys Asp Ile Leu Glu Thr Ser 
                 325                330



<210> 8800
<211> 1258
<212> DNA
<213> Homo sapiens
<308> U66469
<400> 8800

ccgggctct  cccagagca  gaccctgat  gctgcggtg  ttctggtaa  gctttatga  60
tactcgccg  ttttctaca  cgcggtggt  tttacctgc  tcatcgtga  caccggcct  120
gtattggga  ggtttggtt  ggatgttcc  gtaattctg  gaaattcag  agagaccca  180
ttcagcaca  gagttttca  aaagcaaat  agacaagtc  agaatcctt  tggcttaga  240
atcactaat  catcttcag  ttcaattac  actggcata  ccttgacaa  agattgcct  300
gaagatagc  tccttacat  ctactgggg  tgcagtgtt  aaaaattat  tgaagctct  360
cagaagcat  tttattgct  cagaataag  actccccaa  cattagaag  tgctctgta  420
agtgaatat  tctatcagg  acagtattt  attaaaaag  atagcaaag  agaaatata  480
tgccagtta  caagagata  taaaattga  gactttggt  cagtaccca  atctcgcta  540
ccattggta  cgctattga  cttagctga  gaggatgac  gggaaattt  tgatattat  600
tccatggtg  cagtgattc  tattcctga  aggacttat  aactatcct  cagaatatt  660
tatcaatat  tactcttgg  tcaaggtca  tttcatgat  ttaagcaac  tttcatgtc  720
gcaaataat  atttcactc  ctccaacaa  tcctcttca  aagaaaaaa  cacagacag  780
agtttgttg  aaaaggtgg  actctctga  agtgaagtt  agccatcgg  agagaacag  840
aaggactgt  ttgtttgcc  gaatgggac  gtgaactgg  tactcttac  atgcagaca  900
acatgcctg  gtgatggct  tgtgaagta  tttcagcag  gcccaatgt  caggcagtt  960
gttcaggaa  cttttgcac  ttgcagtca  aaagagcaa  ataaagaca  accgaagac  1020
ctttgaaga  atcgtaaca  tgaaaagta  actttctac  aaagatgca  aaattgatg  1080
tcttggaat  catcataac  tggaatcta  agtactgac  atcaatgaa  attatattt  1140
aacttcata  ttgtatggt  cttggatga  aaaaattaa  tattccttt  tgcttagtg  1200
atgaatact  gaatccatc  gtgttgata  aataaaaat  cattcaact  ttgaaaag  1258



<210> 8801
<211> 332
<212> PRT
<213> Homo sapiens
<308> NP_006559
<400> 8801

Met Ala Ala Val Phe Leu Val Thr Leu Tyr Glu Tyr Ser Pro Leu Phe 
  1               5                  10                  15
Tyr Ile Ala Val Val Phe Thr Cys Phe Ile Val Thr Thr Gly Leu Val 
             20                  25                  30
Leu Gly Trp Phe Gly Trp Asp Val Pro Val Ile Leu Arg Asn Ser Glu 
         35                  40                  45
Glu Thr Gln Phe Ser Thr Arg Val Phe Lys Lys Gln Met Arg Gln Val 
     50                  55                  60
Lys Asn Pro Phe Gly Leu Glu Ile Thr Asn Pro Ser Ser Ala Ser Ile 
 65                  70                  75                  80
Thr Thr Gly Ile Thr Leu Thr Thr Asp Cys Leu Glu Asp Ser Leu Leu 
                 85                  90                  95
Thr Cys Tyr Trp Gly Cys Ser Val Gln Lys Leu Tyr Glu Ala Leu Gln 
             100                105                110
Lys His Val Tyr Cys Phe Arg Ile Ser Thr Pro Gln Ala Leu Glu Asp 
         115                120                125
Ala Leu Tyr Ser Glu Tyr Leu Tyr Gln Glu Gln Tyr Phe Ile Lys Lys 
     130                135                140
Asp Ser Lys Glu Glu Ile Tyr Cys Gln Leu Pro Arg Asp Thr Lys Ile 
 145                150                155                160
Glu Asp Phe Gly Thr Val Pro Arg Ser Arg Tyr Pro Leu Val Ala Leu 
                 165                170                175
Leu Thr Leu Ala Asp Glu Asp Asp Arg Glu Ile Tyr Asp Ile Ile Ser 
             180                185                190
Met Val Ser Val Ile His Ile Pro Asp Arg Thr Tyr Lys Leu Ser Cys 
         195                200                205
Arg Ile Leu Tyr Gln Tyr Leu Leu Leu Ala Gln Gly Gln Phe His Asp 
     210                215                220
Leu Lys Gln Leu Phe Met Ser Ala Asn Asn Asn Phe Thr Pro Ser Asn 
 225                230                235                240
Asn Ser Ser Ser Glu Glu Lys Asn Thr Asp Arg Ser Leu Leu Glu Lys 
                 245                250                255
Val Gly Leu Ser Glu Ser Glu Val Glu Pro Ser Glu Glu Asn Ser Lys 
             260                265                270
Asp Cys Val Val Cys Gln Asn Gly Thr Val Asn Trp Val Leu Leu Pro 
         275                280                285
Cys Arg His Thr Cys Leu Cys Asp Gly Cys Val Lys Tyr Phe Gln Gln 
     290                295                300
Cys Pro Met Cys Arg Gln Phe Val Gln Glu Ser Phe Ala Leu Cys Ser 
 305                310                315                320
Gln Lys Glu Gln Asp Lys Asp Lys Pro Lys Thr Leu 
                 325                330



<210> 8802
<211> 1265
<212> DNA
<213> Rattus norvegicus
<308> U66471
<400> 8802

cctgggcga  tgaggacct  caaagtttg  ccgctccgg  gcgccatac  agctcggtt  60
ccggccggc  ggctggtcc  ggcttagcc  ggagacccc  atggccgca  tgttcctgg  120
tacgctcta  gaatactcg  cgctcttct  catcgcggt  gtcttcacc  gcttcatcg  180
caccaccgg  ctggtatta  gatggcttg  ctgggacgt  ccagtaatt  tgagaaact  240
agaagaaac  cagttcagc  caagagctt  caagaaaca  atgagacaa  tgaagaatc  300
gttcggctt  gagatcact  actcatccg  agcttccct  gcaacaggt  taaccttga  360
gacagactg  ctggaagac  gtcgtctta  gtgctactg  gggtgcagt  ttcaaaagc  420
ctatgaagc  cttcagaag  acgtttact  cttcaggat  agcactccg  aagccttgg  480
agaggcgct  tacagtgac  atctccacc  agaacagta  tttattaaa  agcacagca  540
agaagaaat  tattgccaa  taccaagca  tactggggt  gaagacttt  gtccagtgc  600
cagatctcg  tatccgttg  tagctctgt  gaccctcgc  gatgaggat  acagggaaa  660
ttatgacat  atttccatg  tgtctgtca  tcatattcc  gataagact  acaaacttc  720
ctgcagaat  ttgtatcaa  atttaatcc  ggctcaagg  caattttat  atcttaagc  780
acttttcat  tctgcaaat  atagtgcta  tccctccag  gaccagtct  ccgcagacg  840
gagtgtgga  cacagcttg  tggagaagg  ggggctggc  ggggctgaa  tggacccgg  900
ggaggagag  agcaaagac  gtgtggtgt  ccagaacgg  ggtgtgaac  gggtgctcc  960
gccttgccg  cacgcctgc  tgtgcgaca  ctgtgtgtg  tacttcaag  agtgtccca  1020
gtgccgcca  tttgtgcag  aatcctttg  actgtgtgg  cagaaagag  cagacaagg  1080
catactaga  acttcctga  gaatcacag  cggagagtg  actttctac  caagggcag  1140
acctcgtgt  cttagagtc  atcctaaca  agtctgcag  cttacctgt  ggagagagc  1200
ctgtgtgca  tttcatact  tgtacagta  atggatgac  ggaataaag  cttctgctc  1260
gtgcg  1265



<210> 8803
<211> 332
<212> PRT
<213> Rattus norvegicus
<308> AAC52951
<400> 8803

Met Ala Ala Val Phe Leu Val Thr Leu Tyr Glu Tyr Ser Pro Leu Phe 
  1               5                  10                  15
Tyr Ile Ala Val Val Phe Thr Cys Phe Ile Ala Thr Thr Gly Leu Val 
             20                  25                  30
Leu Gly Trp Leu Gly Trp Asp Val Pro Val Ile Leu Arg Asn Ser Glu 
         35                  40                  45
Glu Thr Gln Phe Ser Thr Arg Ala Phe Lys Lys Gln Met Arg Gln Val 
     50                  55                  60
Lys Asn Pro Phe Gly Leu Glu Ile Thr Asn Ser Ser Ala Ala Ser Leu 
 65                  70                  75                  80
Ala Thr Gly Val Thr Leu Thr Thr Asp Cys Leu Glu Asp Ser Arg Leu 
                 85                  90                  95
Thr Cys Tyr Trp Gly Cys Ser Val Gln Lys Leu Tyr Glu Ala Leu Gln 
             100                105                110
Lys His Val Tyr Cys Phe Arg Ile Ser Thr Pro Gln Ala Leu Glu Glu 
         115                120                125
Ala Leu Tyr Ser Asp Tyr Leu His Arg Glu Gln Tyr Phe Ile Lys Lys 
     130                135                140
His Ser Lys Glu Glu Ile Tyr Cys Gln Leu Pro Ser Ser Thr Gly Val 
 145                150                155                160
Glu Asp Phe Gly Pro Val Pro Arg Ser Arg Tyr Pro Leu Val Ala Leu 
                 165                170                175
Leu Thr Leu Ala Asp Glu Asp Asp Arg Glu Ile Tyr Asp Ile Ile Ser 
             180                185                190
Met Val Ser Val Ile His Ile Pro Asp Lys Thr Tyr Lys Leu Pro Cys 
         195                200                205
Arg Ile Leu Tyr Gln Tyr Leu Ile Leu Ala Gln Gly Gln Phe Tyr Asp 
     210                215                220
Leu Lys Gln Leu Phe Met Ser Ala Asn Asn Ser Ala Thr Pro Ser Arg 
 225                230                235                240
Asp Gln Ser Pro Ala Asp Gly Ser Val Glu His Ser Leu Leu Glu Lys 
                 245                250                255
Ala Gly Leu Ala Gly Ala Glu Val Asp Pro Val Glu Glu Ser Ser Lys 
             260                265                270
Asp Cys Val Val Cys Gln Asn Gly Gly Val Asn Trp Val Leu Leu Pro 
         275                280                285
Cys Arg His Ala Cys Leu Cys Asp Ser Cys Val Cys Tyr Phe Lys Gln 
     290                295                300
Cys Pro Met Cys Arg Gln Phe Val Gln Glu Ser Phe Ala Leu Cys Gly 
 305                310                315                320
Gln Lys Glu Ala Asp Lys Asp Ile Leu Glu Thr Ser 
                 325                330



<210> 8804
<211> 1258
<212> DNA
<213> Homo sapiens
<308> U66469
<400> 8804

ccgggctct  cccagagca  gaccctgat  gctgcggtg  ttctggtaa  gctttatga  60
tactcgccg  ttttctaca  cgcggtggt  tttacctgc  tcatcgtga  caccggcct  120
gtattggga  ggtttggtt  ggatgttcc  gtaattctg  gaaattcag  agagaccca  180
ttcagcaca  gagttttca  aaagcaaat  agacaagtc  agaatcctt  tggcttaga  240
atcactaat  catcttcag  ttcaattac  actggcata  ccttgacaa  agattgcct  300
gaagatagc  tccttacat  ctactgggg  tgcagtgtt  aaaaattat  tgaagctct  360
cagaagcat  tttattgct  cagaataag  actccccaa  cattagaag  tgctctgta  420
agtgaatat  tctatcagg  acagtattt  attaaaaag  atagcaaag  agaaatata  480
tgccagtta  caagagata  taaaattga  gactttggt  cagtaccca  atctcgcta  540
ccattggta  cgctattga  cttagctga  gaggatgac  gggaaattt  tgatattat  600
tccatggtg  cagtgattc  tattcctga  aggacttat  aactatcct  cagaatatt  660
tatcaatat  tactcttgg  tcaaggtca  tttcatgat  ttaagcaac  tttcatgtc  720
gcaaataat  atttcactc  ctccaacaa  tcctcttca  aagaaaaaa  cacagacag  780
agtttgttg  aaaaggtgg  actctctga  agtgaagtt  agccatcgg  agagaacag  840
aaggactgt  ttgtttgcc  gaatgggac  gtgaactgg  tactcttac  atgcagaca  900
acatgcctg  gtgatggct  tgtgaagta  tttcagcag  gcccaatgt  caggcagtt  960
gttcaggaa  cttttgcac  ttgcagtca  aaagagcaa  ataaagaca  accgaagac  1020
ctttgaaga  atcgtaaca  tgaaaagta  actttctac  aaagatgca  aaattgatg  1080
tcttggaat  catcataac  tggaatcta  agtactgac  atcaatgaa  attatattt  1140
aacttcata  ttgtatggt  cttggatga  aaaaattaa  tattccttt  tgcttagtg  1200
atgaatact  gaatccatc  gtgttgata  aataaaaat  cattcaact  ttgaaaag  1258



<210> 8805
<211> 332
<212> PRT
<213> Homo sapiens
<308> NP_006559
<400> 8805

Met Ala Ala Val Phe Leu Val Thr Leu Tyr Glu Tyr Ser Pro Leu Phe 
  1               5                  10                  15
Tyr Ile Ala Val Val Phe Thr Cys Phe Ile Val Thr Thr Gly Leu Val 
             20                  25                  30
Leu Gly Trp Phe Gly Trp Asp Val Pro Val Ile Leu Arg Asn Ser Glu 
         35                  40                  45
Glu Thr Gln Phe Ser Thr Arg Val Phe Lys Lys Gln Met Arg Gln Val 
     50                  55                  60
Lys Asn Pro Phe Gly Leu Glu Ile Thr Asn Pro Ser Ser Ala Ser Ile 
 65                  70                  75                  80
Thr Thr Gly Ile Thr Leu Thr Thr Asp Cys Leu Glu Asp Ser Leu Leu 
                 85                  90                  95
Thr Cys Tyr Trp Gly Cys Ser Val Gln Lys Leu Tyr Glu Ala Leu Gln 
             100                105                110
Lys His Val Tyr Cys Phe Arg Ile Ser Thr Pro Gln Ala Leu Glu Asp 
         115                120                125
Ala Leu Tyr Ser Glu Tyr Leu Tyr Gln Glu Gln Tyr Phe Ile Lys Lys 
     130                135                140
Asp Ser Lys Glu Glu Ile Tyr Cys Gln Leu Pro Arg Asp Thr Lys Ile 
 145                150                155                160
Glu Asp Phe Gly Thr Val Pro Arg Ser Arg Tyr Pro Leu Val Ala Leu 
                 165                170                175
Leu Thr Leu Ala Asp Glu Asp Asp Arg Glu Ile Tyr Asp Ile Ile Ser 
             180                185                190
Met Val Ser Val Ile His Ile Pro Asp Arg Thr Tyr Lys Leu Ser Cys 
         195                200                205
Arg Ile Leu Tyr Gln Tyr Leu Leu Leu Ala Gln Gly Gln Phe His Asp 
     210                215                220
Leu Lys Gln Leu Phe Met Ser Ala Asn Asn Asn Phe Thr Pro Ser Asn 
 225                230                235                240
Asn Ser Ser Ser Glu Glu Lys Asn Thr Asp Arg Ser Leu Leu Glu Lys 
                 245                250                255
Val Gly Leu Ser Glu Ser Glu Val Glu Pro Ser Glu Glu Asn Ser Lys 
             260                265                270
Asp Cys Val Val Cys Gln Asn Gly Thr Val Asn Trp Val Leu Leu Pro 
         275                280                285
Cys Arg His Thr Cys Leu Cys Asp Gly Cys Val Lys Tyr Phe Gln Gln 
     290                295                300
Cys Pro Met Cys Arg Gln Phe Val Gln Glu Ser Phe Ala Leu Cys Ser 
 305                310                315                320
Gln Lys Glu Gln Asp Lys Asp Lys Pro Lys Thr Leu 
                 325                330



<210> 8806
<211> 2002
<212> DNA
<213> Rattus norvegicus
<308> U66478
<400> 8806

accaaggcg  ggccagggc  gaggcgcgg  gacggcggc  gagagctaa  cgacgtggg  60
cggtgactg  gaacggatc  gagcgcggg  cccggcccg  gtctcgtgc  tccccgccg  120
tgggcctcc  ccgagccgg  gctaactgg  tcttccctg  agcagaagg  acagtattt  180
ctacctttc  gaaccgaag  ccaagaagc  agagaatct  tgtaaataa  ctgaaatct  240
tgttggctt  gcaccccac  ccggagccg  cacttttac  tggtctgag  agcgtgtag  300
cctcggcca  ccgctatga  tgtgaccag  ttgttttca  tcacaagcc  agctgtgaa  360
agactcctt  ggtggaaac  gggcgacga  gaagagaaa  gggcggaga  ggctgtgga  420
gctttggtg  agaaactga  gaagaagaa  ggggccatg  aagagctgg  gaaggccct  480
agctgcccc  ggcagccca  taactgtgt  accattcct  gctccctgg  tggcaggtt  540
caggtgtcc  accggaagg  actgcctca  gtcatttat  gccgcgtgt  gcgctggcc  600
gacctccag  gccatcatg  actaaagcc  ctggaatgc  gcgagttcc  atttggttc  660
aagcagaag  aagtctgca  caatcccta  cactataag  gagtggaga  ccccgttct  720
ccaccggtg  tggttccga  gcacagcga  tacaaccct  agcacagcc  tctggctca  780
ttccgaaac  tgggacaaa  tgagcccca  atgccactg  atgccacgt  ccccgactc  840
ttccagcag  cacacagcc  cccgtttgc  cagtacccc  acagcagct  ccccaactc  900
cctggcagc  gcagcagca  ctaccctca  tccccgacc  gctcagacc  gggcagccc  960
tttcagatg  cagccgaca  acccccgcc  gcttacctg  ctcctgaag  ccccatggc  1020
caggatggc  ctcagccta  ggacacgaa  atgacgaac  tgacggcac  gacactgcc  1080
gcggagatc  atagaggag  tgttcaagc  gttgcttac  aggaaccaa  acactggtg  1140
tctattgtg  actatgagc  caacaaccg  gtgggcgaa  ggttccatg  ctcctccac  1200
agcgtgttg  tggatggtt  caccgatcc  tccaacaat  agaaccgat  ctgccttgg  1260
ctgctctcc  atgttaacc  gaactccac  attgaaaat  ccaggcgac  catcgggaa  1320
ggagtccac  tttattacg  cggaggaga  gtgtatgcg  agtgcctca  tgacagcag  1380
atcttcgtg  agagtcgaa  ctgcaacta  caccatggc  ttcatccca  cacggtctg  1440
aagatcccc  gcgggtgca  cttgaaaat  ttcaacaac  aagagttcg  tcagctact  1500
gcgcagtct  tgaaccatg  gttcgagac  gagtatgaa  tcaccaaaa  gtgcactat  1560
cgaatgagc  tcgtgaagg  ctggggagc  gagtaccac  ggcaggatg  cactagcac  1620
ccctgctgg  ttgagatac  cctgcatgg  cctctccag  ggctggata  agtccttac  1680
cagatgggt  cgccccaca  ccctatttc  tcggtgtct  aaaggccct  ggcttctgt  1740
tcttgcaaa  tattgggcc  tgcagtact  gaaggacgg  gaagtcaga  aggatgggg  1800
gctgtaaag  agccgtgat  cttgacctc  gtgaccaac  gttggatgg  gaagctgac  1860
ggccttggt  acaagctgt  gatatcaag  acccgctta  tttacattg  gacattctg  1920
tgtaaaatc  actaaaatg  tgactttta  caggacttt  tgaatagtt  gaaaagaga  1980
ggccaagcc  ggggcaaat  at  2002



<210> 8807
<211> 468
<212> PRT
<213> Rattus norvegicus
<308> P97588
<400> 8807

Met Asn Val Thr Ser Leu Phe Ser Phe Thr Ser Pro Ala Val Lys Arg 
  1               5                  10                  15
Leu Leu Gly Trp Lys Gln Gly Asp Glu Glu Glu Lys Trp Ala Glu Lys 
             20                  25                  30
Ala Val Asp Ala Leu Val Lys Lys Leu Lys Lys Lys Lys Gly Ala Met 
         35                  40                  45
Glu Glu Leu Glu Lys Ala Leu Ser Cys Pro Gly Gln Pro Ser Asn Cys 
     50                  55                  60
Val Thr Ile Pro Arg Ser Leu Asp Gly Arg Leu Gln Val Ser His Arg 
 65                  70                  75                  80
Lys Gly Leu Pro His Val Ile Tyr Cys Arg Val Trp Arg Trp Pro Asp 
                 85                  90                  95
Leu Gln Ser His His Glu Leu Lys Pro Leu Glu Cys Cys Glu Phe Pro 
             100                105                110
Phe Gly Ser Lys Gln Lys Glu Val Cys Ile Asn Pro Tyr His Tyr Lys 
         115                120                125
Arg Val Glu Ser Pro Val Leu Pro Pro Val Leu Val Pro Arg His Ser 
     130                135                140
Glu Tyr Asn Pro Gln His Ser Leu Leu Ala Gln Phe Arg Asn Leu Gly 
 145                150                155                160
Gln Asn Glu Pro His Met Pro Leu Asn Ala Thr Phe Pro Asp Ser Phe 
                 165                170                175
Gln Gln Pro His Ser His Pro Phe Ala Gln Tyr Pro Asn Ser Ser Tyr 
             180                185                190
Pro Asn Ser Pro Gly Ser Ser Ser Ser Thr Tyr Pro His Ser Pro Thr 
         195                200                205
Ser Ser Asp Pro Gly Ser Pro Phe Gln Met Pro Ala Asp Thr Pro Pro 
     210                215                220
Pro Ala Tyr Leu Pro Pro Glu Asp Pro Met Ala Gln Asp Gly Ser Gln 
 225                230                235                240
Pro Met Asp Thr Asn Met Thr Asn Met Thr Ala Pro Thr Leu Pro Ala 
                 245                250                255
Glu Ile Asn Arg Gly Asp Val Gln Ala Val Ala Tyr Glu Glu Pro Lys 
             260                265                270
His Trp Cys Ser Ile Val Tyr Tyr Glu Leu Asn Asn Arg Val Gly Glu 
         275                280                285
Arg Phe His Ala Ser Ser Thr Ser Val Leu Val Asp Gly Phe Thr Asp 
     290                295                300
Pro Ser Asn Asn Lys Asn Arg Phe Cys Leu Gly Leu Leu Ser Asn Val 
 305                310                315                320
Asn Arg Asn Ser Thr Ile Glu Asn Thr Arg Arg His Ile Gly Lys Gly 
                 325                330                335
Val His Leu Tyr Tyr Val Gly Gly Glu Val Tyr Ala Glu Cys Leu Ser 
             340                345                350
Asp Ser Ser Ile Phe Val Gln Ser Arg Asn Cys Asn Tyr His His Gly 
         355                360                365
Phe His Pro Thr Thr Val Cys Lys Ile Pro Ser Gly Cys Ser Leu Lys 
     370                375                380
Ile Phe Asn Asn Gln Glu Phe Ala Gln Leu Leu Ala Gln Ser Val Asn 
 385                390                395                400
His Gly Phe Glu Thr Glu Tyr Glu Leu Thr Lys Met Cys Thr Ile Arg 
                 405                410                415
Met Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr His Arg Gln Asp Val 
             420                425                430
Thr Ser Thr Pro Cys Trp Ile Glu Ile His Leu His Gly Pro Leu Gln 
         435                440                445
Trp Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro His Asn Pro Ile 
     450                455                460
Ser Ser Val Ser 
 465



<210> 8808
<211> 1990
<212> DNA
<213> Homo sapiens
<308> U59423
<400> 8808

gaattccgg  ggtattggc  gctgaggag  ggaggctgg  cagctccga  tccctgacg  60
cagcgcgac  agatcaatc  aggctccag  agaaagcag  cgggcgggc  gagaaagga  120
aggccgagc  gctcaaccc  ggccgaggc  cggggagcg  agagtggcg  accgcccgg  180
cgtccggac  cgggccgcg  gaccccgct  gcccggcca  tcgtgctcc  gcacggacg  240
gcgcgccgc  aacccggtg  tgactgggt  actttttta  acactagga  tggtaattt  300
tactcttct  gacttcaaa  taagaagtt  aagagactt  tctgtaaat  aacaaatct  360
ttctgctgt  cttttgcat  tggagacag  tttatttca  catatccaa  gagtataac  420
agtgctgtc  ttatgaatg  gacaagttt  ttttccttt  caagtccag  tgtgaagag  480
cttcttggg  ggaaacagg  cgatgaaga  gaaaaatgg  cagagaaag  tgttgatgc  540
ttggtgaaa  aactgaaga  aaagaaagg  gccatggag  aactggaaa  ggccttgag  600
tgcccaggg  aaccgagta  ctgtgtcac  attccccgc  ctctggatg  caggctgca  660
gtctcccac  ggaagggac  gcctcatgt  atttactgc  gtgtgtggc  ctggcccga  720
cttcagagc  accatgaac  aaaaccact  gaatgctgt  agtttcctt  tggttccaa  780
cagaaggag  tctgcatca  tccctacca  tataagaga  tagaaagcc  tgtacttcc  840
cctgtgctg  ttccaagac  cagcgaata  aatcctcag  acagcctct  agctcagtt  900
cgtaactta  gacaaaatg  gcctcacat  ccactcaac  ccacttttc  agattcttt  960
cagcaaccc  acagccacc  gtttcctca  tctcccaat  gcagttacc  aaactctcc  1020
gggagcagc  gcagcacct  ccctcactc  cccaccagc  cagacccag  aagcccttt  1080
cagatgcca  ctgatacgc  cccacctgc  tacctgcct  ctgaagacc  catgaccca  1140
gatggctct  agccgatgg  cacaaacat  atggcgcct  ccctgccct  agaaatcaa  1200
agaggagat  ttcaggcgg  tgcttatga  gaaccaaaa  actggtgct  tattgtcta  1260
tatgagctc  acaatcgtg  gggtgaagc  ttccatgcc  cctccacaa  tgtgttggt  1320
gatggtttc  ctgatcctt  caacaataa  aaccgtttc  gccttgggc  gctctccaa  1380
gttaaccgg  attccacta  tgaaaacac  aggcggcat  ttggaaaag  agttcatct  1440
tattatgtt  gaggggagg  gtatgccga  tgccttagt  acagtagca  ctttgtgca  1500
agtcggaac  gcaactacc  tcatggatt  catcctact  ctgtttgca  gatccctag  1560
gggtgtagt  tgaaaattt  taacaacca  gaatttgct  agttattgg  acagtctgt  1620
aaccatgga  ttgagacag  ctatgagct  acaaaaatg  gtactatac  tatgagctt  1680
gtgaagggc  ggggagcag  ataccaccg  caggatgtt  ctagcaccc  ctgctggat  1740
gagatacat  tgcacggcc  cctccagtg  ctggataaa  ttcttactc  aatgggttc  1800
cctcataat  ctatttcat  tgtatctta  atggcccca  catctgcct  tggaaaact  1860
ttgagcctt  catgtactt  aaggatgga  gagtcagac  cgattgaga  ctgacaaag  1920
agccttgat  atacttgac  tctgtgacc  actgttgga  tcagaaatt  aaacaaaaa  1980
aaaaaaaaaa  1990



<210> 8809
<211> 465
<212> PRT
<213> Homo sapiens
<308> Q15797
<400> 8809

Met Asn Val Thr Ser Leu Phe Ser Phe Thr Ser Pro Ala Val Lys Arg 
  1               5                  10                  15
Leu Leu Gly Trp Lys Gln Gly Asp Glu Glu Glu Lys Trp Ala Glu Lys 
             20                  25                  30
Ala Val Asp Ala Leu Val Lys Lys Leu Lys Lys Lys Lys Gly Ala Met 
         35                  40                  45
Glu Glu Leu Glu Lys Ala Leu Ser Cys Pro Gly Gln Pro Ser Asn Cys 
     50                  55                  60
Val Thr Ile Pro Arg Ser Leu Asp Gly Arg Leu Gln Val Ser His Arg 
 65                  70                  75                  80
Lys Gly Leu Pro His Val Ile Tyr Cys Arg Val Trp Arg Trp Pro Asp 
                 85                  90                  95
Leu Gln Ser His His Glu Leu Lys Pro Leu Glu Cys Cys Glu Phe Pro 
             100                105                110
Phe Gly Ser Lys Gln Lys Glu Val Cys Ile Asn Pro Tyr His Tyr Lys 
         115                120                125
Arg Val Glu Ser Pro Val Leu Pro Pro Val Leu Val Pro Arg His Ser 
     130                135                140
Glu Tyr Asn Pro Gln His Ser Leu Leu Ala Gln Phe Arg Asn Leu Gly 
 145                150                155                160
Gln Asn Glu Pro His Met Pro Leu Asn Ala Thr Phe Pro Asp Ser Phe 
                 165                170                175
Gln Gln Pro Asn Ser His Pro Phe Pro His Ser Pro Asn Ser Ser Tyr 
             180                185                190
Pro Asn Ser Pro Gly Ser Ser Ser Ser Thr Tyr Pro His Ser Pro Thr 
         195                200                205
Ser Ser Asp Pro Gly Ser Pro Phe Gln Met Pro Ala Asp Thr Pro Pro 
     210                215                220
Pro Ala Tyr Leu Pro Pro Glu Asp Pro Met Thr Gln Asp Gly Ser Gln 
 225                230                235                240
Pro Met Asp Thr Asn Met Met Ala Pro Pro Leu Pro Ser Glu Ile Asn 
                 245                250                255
Arg Gly Asp Val Gln Ala Val Ala Tyr Glu Glu Pro Lys His Trp Cys 
             260                265                270
Ser Ile Val Tyr Tyr Glu Leu Asn Asn Arg Val Gly Glu Ala Phe His 
         275                280                285
Ala Ser Ser Thr Ser Val Leu Val Asp Gly Phe Thr Asp Pro Ser Asn 
     290                295                300
Asn Lys Asn Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn Arg Asn 
 305                310                315                320
Ser Thr Ile Glu Asn Thr Arg Arg His Ile Gly Lys Gly Val His Leu 
                 325                330                335
Tyr Tyr Val Gly Gly Glu Val Tyr Ala Glu Cys Leu Ser Asp Ser Ser 
             340                345                350
Ile Phe Val Gln Ser Arg Asn Cys Asn Tyr His His Gly Phe His Pro 
         355                360                365
Thr Thr Val Cys Lys Ile Pro Ser Gly Cys Ser Leu Lys Ile Phe Asn 
     370                375                380
Asn Gln Glu Phe Ala Gln Leu Leu Ala Gln Ser Val Asn His Gly Phe 
 385                390                395                400
Glu Thr Val Tyr Glu Leu Thr Lys Met Cys Thr Ile Arg Met Ser Phe 
                 405                410                415
Val Lys Gly Trp Gly Ala Glu Tyr His Arg Gln Asp Val Thr Ser Thr 
             420                425                430
Pro Cys Trp Ile Glu Ile His Leu His Gly Pro Leu Gln Trp Leu Asp 
         435                440                445
Lys Val Leu Thr Gln Met Gly Ser Pro His Asn Pro Ile Ser Ser Val 
     450                455                460
Ser 
 465



<210> 8810
<211> 2002
<212> DNA
<213> Rattus norvegicus
<308> U66478
<400> 8810

accaaggcg  ggccagggc  gaggcgcgg  gacggcggc  gagagctaa  cgacgtggg  60
cggtgactg  gaacggatc  gagcgcggg  cccggcccg  gtctcgtgc  tccccgccg  120
tgggcctcc  ccgagccgg  gctaactgg  tcttccctg  agcagaagg  acagtattt  180
ctacctttc  gaaccgaag  ccaagaagc  agagaatct  tgtaaataa  ctgaaatct  240
tgttggctt  gcaccccac  ccggagccg  cacttttac  tggtctgag  agcgtgtag  300
cctcggcca  ccgctatga  tgtgaccag  ttgttttca  tcacaagcc  agctgtgaa  360
agactcctt  ggtggaaac  gggcgacga  gaagagaaa  gggcggaga  ggctgtgga  420
gctttggtg  agaaactga  gaagaagaa  ggggccatg  aagagctgg  gaaggccct  480
agctgcccc  ggcagccca  taactgtgt  accattcct  gctccctgg  tggcaggtt  540
caggtgtcc  accggaagg  actgcctca  gtcatttat  gccgcgtgt  gcgctggcc  600
gacctccag  gccatcatg  actaaagcc  ctggaatgc  gcgagttcc  atttggttc  660
aagcagaag  aagtctgca  caatcccta  cactataag  gagtggaga  ccccgttct  720
ccaccggtg  tggttccga  gcacagcga  tacaaccct  agcacagcc  tctggctca  780
ttccgaaac  tgggacaaa  tgagcccca  atgccactg  atgccacgt  ccccgactc  840
ttccagcag  cacacagcc  cccgtttgc  cagtacccc  acagcagct  ccccaactc  900
cctggcagc  gcagcagca  ctaccctca  tccccgacc  gctcagacc  gggcagccc  960
tttcagatg  cagccgaca  acccccgcc  gcttacctg  ctcctgaag  ccccatggc  1020
caggatggc  ctcagccta  ggacacgaa  atgacgaac  tgacggcac  gacactgcc  1080
gcggagatc  atagaggag  tgttcaagc  gttgcttac  aggaaccaa  acactggtg  1140
tctattgtg  actatgagc  caacaaccg  gtgggcgaa  ggttccatg  ctcctccac  1200
agcgtgttg  tggatggtt  caccgatcc  tccaacaat  agaaccgat  ctgccttgg  1260
ctgctctcc  atgttaacc  gaactccac  attgaaaat  ccaggcgac  catcgggaa  1320
ggagtccac  tttattacg  cggaggaga  gtgtatgcg  agtgcctca  tgacagcag  1380
atcttcgtg  agagtcgaa  ctgcaacta  caccatggc  ttcatccca  cacggtctg  1440
aagatcccc  gcgggtgca  cttgaaaat  ttcaacaac  aagagttcg  tcagctact  1500
gcgcagtct  tgaaccatg  gttcgagac  gagtatgaa  tcaccaaaa  gtgcactat  1560
cgaatgagc  tcgtgaagg  ctggggagc  gagtaccac  ggcaggatg  cactagcac  1620
ccctgctgg  ttgagatac  cctgcatgg  cctctccag  ggctggata  agtccttac  1680
cagatgggt  cgccccaca  ccctatttc  tcggtgtct  aaaggccct  ggcttctgt  1740
tcttgcaaa  tattgggcc  tgcagtact  gaaggacgg  gaagtcaga  aggatgggg  1800
gctgtaaag  agccgtgat  cttgacctc  gtgaccaac  gttggatgg  gaagctgac  1860
ggccttggt  acaagctgt  gatatcaag  acccgctta  tttacattg  gacattctg  1920
tgtaaaatc  actaaaatg  tgactttta  caggacttt  tgaatagtt  gaaaagaga  1980
ggccaagcc  ggggcaaat  at  2002



<210> 8811
<211> 468
<212> PRT
<213> Rattus norvegicus
<308> P97588
<400> 8811

Met Asn Val Thr Ser Leu Phe Ser Phe Thr Ser Pro Ala Val Lys Arg 
  1               5                  10                  15
Leu Leu Gly Trp Lys Gln Gly Asp Glu Glu Glu Lys Trp Ala Glu Lys 
             20                  25                  30
Ala Val Asp Ala Leu Val Lys Lys Leu Lys Lys Lys Lys Gly Ala Met 
         35                  40                  45
Glu Glu Leu Glu Lys Ala Leu Ser Cys Pro Gly Gln Pro Ser Asn Cys 
     50                  55                  60
Val Thr Ile Pro Arg Ser Leu Asp Gly Arg Leu Gln Val Ser His Arg 
 65                  70                  75                  80
Lys Gly Leu Pro His Val Ile Tyr Cys Arg Val Trp Arg Trp Pro Asp 
                 85                  90                  95
Leu Gln Ser His His Glu Leu Lys Pro Leu Glu Cys Cys Glu Phe Pro 
             100                105                110
Phe Gly Ser Lys Gln Lys Glu Val Cys Ile Asn Pro Tyr His Tyr Lys 
         115                120                125
Arg Val Glu Ser Pro Val Leu Pro Pro Val Leu Val Pro Arg His Ser 
     130                135                140
Glu Tyr Asn Pro Gln His Ser Leu Leu Ala Gln Phe Arg Asn Leu Gly 
 145                150                155                160
Gln Asn Glu Pro His Met Pro Leu Asn Ala Thr Phe Pro Asp Ser Phe 
                 165                170                175
Gln Gln Pro His Ser His Pro Phe Ala Gln Tyr Pro Asn Ser Ser Tyr 
             180                185                190
Pro Asn Ser Pro Gly Ser Ser Ser Ser Thr Tyr Pro His Ser Pro Thr 
         195                200                205
Ser Ser Asp Pro Gly Ser Pro Phe Gln Met Pro Ala Asp Thr Pro Pro 
     210                215                220
Pro Ala Tyr Leu Pro Pro Glu Asp Pro Met Ala Gln Asp Gly Ser Gln 
 225                230                235                240
Pro Met Asp Thr Asn Met Thr Asn Met Thr Ala Pro Thr Leu Pro Ala 
                 245                250                255
Glu Ile Asn Arg Gly Asp Val Gln Ala Val Ala Tyr Glu Glu Pro Lys 
             260                265                270
His Trp Cys Ser Ile Val Tyr Tyr Glu Leu Asn Asn Arg Val Gly Glu 
         275                280                285
Arg Phe His Ala Ser Ser Thr Ser Val Leu Val Asp Gly Phe Thr Asp 
     290                295                300
Pro Ser Asn Asn Lys Asn Arg Phe Cys Leu Gly Leu Leu Ser Asn Val 
 305                310                315                320
Asn Arg Asn Ser Thr Ile Glu Asn Thr Arg Arg His Ile Gly Lys Gly 
                 325                330                335
Val His Leu Tyr Tyr Val Gly Gly Glu Val Tyr Ala Glu Cys Leu Ser 
             340                345                350
Asp Ser Ser Ile Phe Val Gln Ser Arg Asn Cys Asn Tyr His His Gly 
         355                360                365
Phe His Pro Thr Thr Val Cys Lys Ile Pro Ser Gly Cys Ser Leu Lys 
     370                375                380
Ile Phe Asn Asn Gln Glu Phe Ala Gln Leu Leu Ala Gln Ser Val Asn 
 385                390                395                400
His Gly Phe Glu Thr Glu Tyr Glu Leu Thr Lys Met Cys Thr Ile Arg 
                 405                410                415
Met Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr His Arg Gln Asp Val 
             420                425                430
Thr Ser Thr Pro Cys Trp Ile Glu Ile His Leu His Gly Pro Leu Gln 
         435                440                445
Trp Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro His Asn Pro Ile 
     450                455                460
Ser Ser Val Ser 
 465



<210> 8812
<211> 1990
<212> DNA
<213> Homo sapiens
<308> U59423
<400> 8812

gaattccgg  ggtattggc  gctgaggag  ggaggctgg  cagctccga  tccctgacg  60
cagcgcgac  agatcaatc  aggctccag  agaaagcag  cgggcgggc  gagaaagga  120
aggccgagc  gctcaaccc  ggccgaggc  cggggagcg  agagtggcg  accgcccgg  180
cgtccggac  cgggccgcg  gaccccgct  gcccggcca  tcgtgctcc  gcacggacg  240
gcgcgccgc  aacccggtg  tgactgggt  actttttta  acactagga  tggtaattt  300
tactcttct  gacttcaaa  taagaagtt  aagagactt  tctgtaaat  aacaaatct  360
ttctgctgt  cttttgcat  tggagacag  tttatttca  catatccaa  gagtataac  420
agtgctgtc  ttatgaatg  gacaagttt  ttttccttt  caagtccag  tgtgaagag  480
cttcttggg  ggaaacagg  cgatgaaga  gaaaaatgg  cagagaaag  tgttgatgc  540
ttggtgaaa  aactgaaga  aaagaaagg  gccatggag  aactggaaa  ggccttgag  600
tgcccaggg  aaccgagta  ctgtgtcac  attccccgc  ctctggatg  caggctgca  660
gtctcccac  ggaagggac  gcctcatgt  atttactgc  gtgtgtggc  ctggcccga  720
cttcagagc  accatgaac  aaaaccact  gaatgctgt  agtttcctt  tggttccaa  780
cagaaggag  tctgcatca  tccctacca  tataagaga  tagaaagcc  tgtacttcc  840
cctgtgctg  ttccaagac  cagcgaata  aatcctcag  acagcctct  agctcagtt  900
cgtaactta  gacaaaatg  gcctcacat  ccactcaac  ccacttttc  agattcttt  960
cagcaaccc  acagccacc  gtttcctca  tctcccaat  gcagttacc  aaactctcc  1020
gggagcagc  gcagcacct  ccctcactc  cccaccagc  cagacccag  aagcccttt  1080
cagatgcca  ctgatacgc  cccacctgc  tacctgcct  ctgaagacc  catgaccca  1140
gatggctct  agccgatgg  cacaaacat  atggcgcct  ccctgccct  agaaatcaa  1200
agaggagat  ttcaggcgg  tgcttatga  gaaccaaaa  actggtgct  tattgtcta  1260
tatgagctc  acaatcgtg  gggtgaagc  ttccatgcc  cctccacaa  tgtgttggt  1320
gatggtttc  ctgatcctt  caacaataa  aaccgtttc  gccttgggc  gctctccaa  1380
gttaaccgg  attccacta  tgaaaacac  aggcggcat  ttggaaaag  agttcatct  1440
tattatgtt  gaggggagg  gtatgccga  tgccttagt  acagtagca  ctttgtgca  1500
agtcggaac  gcaactacc  tcatggatt  catcctact  ctgtttgca  gatccctag  1560
gggtgtagt  tgaaaattt  taacaacca  gaatttgct  agttattgg  acagtctgt  1620
aaccatgga  ttgagacag  ctatgagct  acaaaaatg  gtactatac  tatgagctt  1680
gtgaagggc  ggggagcag  ataccaccg  caggatgtt  ctagcaccc  ctgctggat  1740
gagatacat  tgcacggcc  cctccagtg  ctggataaa  ttcttactc  aatgggttc  1800
cctcataat  ctatttcat  tgtatctta  atggcccca  catctgcct  tggaaaact  1860
ttgagcctt  catgtactt  aaggatgga  gagtcagac  cgattgaga  ctgacaaag  1920
agccttgat  atacttgac  tctgtgacc  actgttgga  tcagaaatt  aaacaaaaa  1980
aaaaaaaaaa  1990



<210> 8813
<211> 465
<212> PRT
<213> Homo sapiens
<308> Q15797
<400> 8813

Met Asn Val Thr Ser Leu Phe Ser Phe Thr Ser Pro Ala Val Lys Arg 
  1               5                  10                  15
Leu Leu Gly Trp Lys Gln Gly Asp Glu Glu Glu Lys Trp Ala Glu Lys 
             20                  25                  30
Ala Val Asp Ala Leu Val Lys Lys Leu Lys Lys Lys Lys Gly Ala Met 
         35                  40                  45
Glu Glu Leu Glu Lys Ala Leu Ser Cys Pro Gly Gln Pro Ser Asn Cys 
     50                  55                  60
Val Thr Ile Pro Arg Ser Leu Asp Gly Arg Leu Gln Val Ser His Arg 
 65                  70                  75                  80
Lys Gly Leu Pro His Val Ile Tyr Cys Arg Val Trp Arg Trp Pro Asp 
                 85                  90                  95
Leu Gln Ser His His Glu Leu Lys Pro Leu Glu Cys Cys Glu Phe Pro 
             100                105                110
Phe Gly Ser Lys Gln Lys Glu Val Cys Ile Asn Pro Tyr His Tyr Lys 
         115                120                125
Arg Val Glu Ser Pro Val Leu Pro Pro Val Leu Val Pro Arg His Ser 
     130                135                140
Glu Tyr Asn Pro Gln His Ser Leu Leu Ala Gln Phe Arg Asn Leu Gly 
 145                150                155                160
Gln Asn Glu Pro His Met Pro Leu Asn Ala Thr Phe Pro Asp Ser Phe 
                 165                170                175
Gln Gln Pro Asn Ser His Pro Phe Pro His Ser Pro Asn Ser Ser Tyr 
             180                185                190
Pro Asn Ser Pro Gly Ser Ser Ser Ser Thr Tyr Pro His Ser Pro Thr 
         195                200                205
Ser Ser Asp Pro Gly Ser Pro Phe Gln Met Pro Ala Asp Thr Pro Pro 
     210                215                220
Pro Ala Tyr Leu Pro Pro Glu Asp Pro Met Thr Gln Asp Gly Ser Gln 
 225                230                235                240
Pro Met Asp Thr Asn Met Met Ala Pro Pro Leu Pro Ser Glu Ile Asn 
                 245                250                255
Arg Gly Asp Val Gln Ala Val Ala Tyr Glu Glu Pro Lys His Trp Cys 
             260                265                270
Ser Ile Val Tyr Tyr Glu Leu Asn Asn Arg Val Gly Glu Ala Phe His 
         275                280                285
Ala Ser Ser Thr Ser Val Leu Val Asp Gly Phe Thr Asp Pro Ser Asn 
     290                295                300
Asn Lys Asn Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn Arg Asn 
 305                310                315                320
Ser Thr Ile Glu Asn Thr Arg Arg His Ile Gly Lys Gly Val His Leu 
                 325                330                335
Tyr Tyr Val Gly Gly Glu Val Tyr Ala Glu Cys Leu Ser Asp Ser Ser 
             340                345                350
Ile Phe Val Gln Ser Arg Asn Cys Asn Tyr His His Gly Phe His Pro 
         355                360                365
Thr Thr Val Cys Lys Ile Pro Ser Gly Cys Ser Leu Lys Ile Phe Asn 
     370                375                380
Asn Gln Glu Phe Ala Gln Leu Leu Ala Gln Ser Val Asn His Gly Phe 
 385                390                395                400
Glu Thr Val Tyr Glu Leu Thr Lys Met Cys Thr Ile Arg Met Ser Phe 
                 405                410                415
Val Lys Gly Trp Gly Ala Glu Tyr His Arg Gln Asp Val Thr Ser Thr 
             420                425                430
Pro Cys Trp Ile Glu Ile His Leu His Gly Pro Leu Gln Trp Leu Asp 
         435                440                445
Lys Val Leu Thr Gln Met Gly Ser Pro His Asn Pro Ile Ser Ser Val 
     450                455                460
Ser 
 465



<210> 8814
<211> 2830
<212> DNA
<213> Rattus norvegicus
<308> U67081
<400> 8814

gaattcggc  cgagggagc  actcggata  gatgaacct  atgcggctg  aggagcagc  60
aagccccag  tctagaacg  tctccagct  tgccaagga  gatgggtgt  atgagaggg  120
tgatgacac  acctcagtg  actcagaca  gtctgagga  gtatttgac  tgaccaagg  180
caacctgac  ctgctagag  aagccattg  cttggagac  gagagagcc  aggccatgc  240
agagaagat  gccatggat  ctgggagaa  ggataacct  agatcctat  aggaccagt  300
tccaagaca  ctggctggg  aagacagaa  atccaaatc  agtgacagc  atgtcaaaa  360
gccatacta  gatccctca  gaacagaaa  gagagagag  aagtgtcca  cccccgggt  420
tgatggaac  ggccacgta  ctgggcttt  cccgcatca  cgcagtctg  ctggatgcc  480
gcacaaaga  agggtccct  cagaaattc  tgccatgca  gaaaatgtt  tcaagtgtc  540
cactccagg  tgcacaggg  gagggcatg  gcatagcaa  aggaactcg  acagaagcc  600
ctctggatg  cctattgct  ctgcagaaa  actggcaaa  gcccaggag  aacatcaga  660
ctgtgatgt  tccaaatcc  accaggcct  agaccgagt  ctcaggcca  tgtgctttg  720
caaacagct  gagattcct  agtatggct  cagaaacaa  gttcccaca  ctacaccgc  780
ctccaacct  gccaaggag  ttgagaaat  ttccaagac  tcgtttgag  acaacagtt  840
cgacaacca  acttatggc  aaagagcca  agctcccaa  gtgcaaacc  gggacatat  900
ccccaaagg  tatgacgat  ccaagcggt  ctgcaagaa  gccagcccc  gcagcagca  960
caccagcag  tatgcaccc  gcagcagca  caacctcag  tgtggtggt  gcagcagtg  1020
cagtagcac  tgtagcaag  gcagctttg  ctacacaca  gacatggag  ccgcacaca  1080
ggcagccac  gccattctc  acctgtcca  acgttgccg  gaaatgcca  agaacctgt  1140
caccaagcc  caggacctg  gcactgccc  gaacccaga  atggaggtg  atgagaatg  1200
gaccctgga  ctgagcatg  acaagcaga  gcctcgaga  agctgctgc  cagtcctga  1260
acccctgga  cccatgtcc  cccagcagc  ggcagtgat  acgagccga  gcttccaac  1320
gagcgaggg  gattgttgg  acttacccg  agactacac  aaaatgaag  ctcggaggg  1380
agatgagga  gaccccaaa  agattaccc  agaagactt  gacccattc  aggaggctc  1440
ggaagaaag  agatatcca  gggaggtga  catcccaag  cccaaaccc  agtaccctc  1500
atgcaagga  agcaaaaag  acttaataa  tctgtctgg  tgccccctg  cggacaaaa  1560
cattcgaag  atgctggcc  ccagttccc  agagctcaa  tgccccacc  ctggctgtg  1620
cggttctgg  cacatcact  gcatctacg  ttctcatcg  agcctttcc  ggtgcccaa  1680
agcaaagaa  agtggtatc  ggatagcac  aagcaaaga  gacaaggaa  accaggagc  1740
aatcaggtg  ccggtacct  gctgtgatg  tcagggaca  atcactggg  agtacgcat  1800
ccaccgcag  gcctctggg  gccccttgg  agccaagag  cagaaagat  ggtacctta  1860
tggctccca  ttctcctgg  agtcagtca  gacagaggg  atgtcctgc  ctacacccg  1920
gtgtgatgg  tcaggacac  tcagtgcta  cttcctcac  caccgcagc  tgtcaggat  1980
tccaagagc  acatcagca  tgaagaaag  aaagctgtc  ggagaacag  tgttgacta  2040
caagcagcg  gccagcaac  gtatagaaa  cgatgagga  atcaagcag  tggatgaag  2100
gatcaagga  ctcaatgag  ccaattccc  gatggaggc  gacatgatc  aactcagaa  2160
tcagatcac  acaatggat  gcaacctga  gacgattga  gaggagaac  aagtcattg  2220
gcagcagaa  gagtcgctc  tgcacgagt  ggccaacct  agccagtcc  tgatccaca  2280
cctcgccaa  atccagctg  ctcacatgg  tccaatcaa  gaacaaaat  ttgatgctt  2340
cgtgactac  ttgacggaa  tgtatacaa  tcaagatcg  tatcagagt  cagaaaata  2400
agccctact  gaaaatata  agcaggctg  gagaggaat  caggtctga  cagctgctc  2460
agtggtgac  catgcttaa  aaggatgcc  cttgtttct  gctgctgta  cttaccaga  2520
agtgttata  atttatttc  gtcggaaca  tgttatgct  caagacttc  taatggttt  2580
gtgtgctct  gagatagta  ctgcagact  gttttggat  cattcacat  ttgtacgtt  2640
tcatataag  tgacatagt  tgatttccc  tgtaatgtt  atagctgct  ctgtctgca  2700
atttggggg  ctctatatt  ctgaagagg  aagctgacg  aaataaata  agtgtaaat  2760
ctttttaat  ctttagtga  taaatgttt  agtattttg  actgaaatg  acaaaaaaa  2820
aaaaaaaaaa  2830



<210> 8815
<211> 815
<212> PRT
<213> Rattus norvegicus
<308> AAB40718
<400> 8815

Asn Ser Ala Arg Gly Ser Tyr Ser Asp Met Met Asn Leu Met Arg Leu 
  1               5                  10                  15
Glu Glu Gln Leu Ser Pro Arg Ser Arg Thr Phe Ser Ser Cys Ala Lys 
             20                  25                  30
Glu Asp Gly Cys His Glu Arg Asp Asp Asp Thr Thr Ser Val Asn Ser 
         35                  40                  45
Asp Arg Ser Glu Glu Val Phe Asp Met Thr Lys Gly Asn Leu Thr Leu 
     50                  55                  60
Leu Glu Lys Ala Ile Ala Leu Glu Thr Glu Arg Ala Lys Ala Met Arg 
 65                  70                  75                  80
Glu Lys Met Ala Met Asp Ala Gly Arg Arg Asp Asn Leu Arg Ser Tyr 
                 85                  90                  95
Glu Asp Gln Ser Pro Arg Gln Leu Ala Gly Glu Asp Arg Lys Ser Lys 
             100                105                110
Ser Ser Asp Ser His Val Lys Lys Pro Tyr Tyr Asp Pro Ser Arg Thr 
         115                120                125
Glu Lys Arg Glu Ser Lys Cys Pro Thr Pro Gly Cys Asp Gly Thr Gly 
     130                135                140
His Val Thr Gly Leu Tyr Pro His His Arg Ser Leu Ser Gly Cys Pro 
 145                150                155                160
His Lys Asp Arg Val Pro Pro Glu Ile Leu Ala Met His Glu Asn Val 
                 165                170                175
Leu Lys Cys Pro Thr Pro Gly Cys Thr Gly Arg Gly His Val His Ser 
             180                185                190
Asn Arg Asn Ser His Arg Ser Leu Ser Gly Cys Pro Ile Ala Ala Ala 
         195                200                205
Glu Lys Leu Ala Lys Ala Gln Glu Lys His Gln Ser Cys Asp Val Ser 
     210                215                220
Lys Ser Asn Gln Ala Ser Asp Arg Val Leu Arg Pro Met Cys Phe Val 
 225                230                235                240
Lys Gln Leu Glu Ile Pro Gln Tyr Gly Tyr Arg Asn Asn Val Pro Thr 
                 245                250                255
Thr Thr Pro Arg Ser Asn Leu Ala Lys Glu Leu Glu Lys Tyr Ser Lys 
             260                265                270
Thr Ser Phe Glu Tyr Asn Ser Tyr Asp Asn His Thr Tyr Gly Lys Arg 
         275                280                285
Ala Ile Ala Pro Lys Val Gln Thr Arg Asp Ile Ser Pro Lys Gly Tyr 
     290                295                300
Asp Asp Ala Lys Arg Tyr Cys Lys Asn Ala Ser Pro Ser Ser Ser Thr 
 305                310                315                320
Thr Ser Ser Tyr Ala Pro Ser Ser Ser Ser Asn Leu Ser Cys Gly Gly 
                 325                330                335
Gly Ser Ser Ala Ser Ser Thr Cys Ser Lys Ser Ser Phe Asp Tyr Thr 
             340                345                350
His Asp Met Glu Ala Ala His Met Ala Ala Thr Ala Ile Leu Asn Leu 
         355                360                365
Ser Thr Arg Cys Arg Glu Met Pro Gln Asn Leu Ser Thr Lys Pro Gln 
     370                375                380
Asp Leu Cys Thr Ala Arg Asn Pro Asp Met Glu Val Asp Glu Asn Gly 
 385                390                395                400
Thr Leu Asp Leu Ser Met Asn Lys Gln Arg Pro Arg Asp Ser Cys Cys 
                 405                410                415
Pro Val Leu Thr Pro Leu Glu Pro Met Ser Pro Gln Gln Gln Ala Val 
             420                425                430
Met Thr Ser Arg Cys Phe Gln Leu Ser Glu Gly Asp Cys Trp Asp Leu 
         435                440                445
Pro Val Asp Tyr Thr Lys Met Lys Pro Arg Arg Val Asp Glu Glu Asp 
     450                455                460
Pro Lys Glu Ile Thr Pro Glu Asp Leu Asp Pro Phe Gln Glu Ala Leu 
 465                470                475                480
Glu Glu Arg Arg Tyr Pro Gly Glu Val Thr Ile Pro Ser Pro Lys Pro 
                 485                490                495
Lys Tyr Pro Gln Cys Lys Glu Ser Lys Lys Asp Leu Ile Thr Leu Ser 
             500                505                510
Gly Cys Pro Leu Ala Asp Lys Ser Ile Arg Ser Met Leu Ala Thr Ser 
         515                520                525
Ser Gln Glu Leu Lys Cys Pro Thr Pro Gly Cys Asp Gly Ser Gly His 
     530                535                540
Ile Thr Gly Ile Tyr Ala Ser His Arg Ser Leu Ser Gly Cys Pro Arg 
 545                550                555                560
Ala Lys Lys Ser Gly Ile Arg Ile Ala Gln Ser Lys Glu Asp Lys Glu 
                 565                570                575
Asp Gln Glu Pro Ile Arg Cys Pro Val Pro Gly Cys Asp Gly Gln Gly 
             580                585                590
His Ile Thr Gly Lys Tyr Ala Ser His Arg Ser Ala Ser Gly Cys Pro 
         595                600                605
Leu Ala Ala Lys Arg Gln Lys Asp Gly Tyr Leu Asn Gly Ser Gln Phe 
     610                615                620
Ser Trp Lys Ser Val Lys Thr Glu Gly Met Ser Cys Pro Thr Pro Gly 
 625                630                635                640
Cys Asp Gly Ser Gly His Val Ser Ala Ser Phe Leu Thr His Arg Ser 
                 645                650                655
Leu Ser Gly Cys Pro Arg Ala Thr Ser Ala Met Lys Lys Ala Lys Leu 
             660                665                670
Ser Gly Glu Gln Met Leu Thr Ile Lys Gln Arg Ala Ser Asn Gly Ile 
         675                680                685
Glu Asn Asp Glu Glu Ile Lys Gln Leu Asp Glu Glu Ile Lys Glu Leu 
     690                695                700
Asn Glu Ser Asn Ser Gln Met Glu Ala Asp Met Ile Lys Leu Arg Thr 
 705                710                715                720
Gln Ile Thr Thr Met Asp Ser Asn Leu Lys Thr Ile Glu Glu Glu Asn 
                 725                730                735
Lys Val Ile Glu Gln Gln Asn Glu Ser Leu Leu His Glu Leu Ala Asn 
             740                745                750
Leu Ser Gln Ser Leu Ile His Ser Leu Ala Asn Ile Gln Leu Pro His 
         755                760                765
Met Asp Pro Ile Asn Glu Gln Asn Phe Asp Ala Tyr Val Thr Thr Leu 
     770                775                780
Thr Glu Met Tyr Thr Asn Gln Asp Arg Tyr Gln Ser Pro Glu Asn Lys 
 785                790                795                800
Ala Leu Leu Glu Asn Ile Lys Gln Ala Val Arg Gly Ile Gln Val 
                 805                810                815



<210> 8816
<211> 3164
<212> DNA
<213> Homo sapiens
<308> AK057398
<400> 8816

agtcaataa  ctagggctt  accatgcca  atccaaaat  ttctgttgt  gatctctgg  60
atcaacagc  cagaaactg  agaacagac  cctgacagt  accaacact  tcctccaaa  120
agcattctg  ttactgttt  atgtattct  aggagttca  ctttgctcc  ctttgggaa  180
tggaacaaa  gctctggtg  agacaggga  cacaggaca  atttacctg  aggggatat  240
aaagagcag  ctcaagact  gcaaaacaa  gtcgtccca  tgaattatc  gtgcctaca  300
ccgcacttg  caccttcgg  taagccagc  tctgacaag  agttgttcc  acggcagcc  360
cccctgcct  ccatcttag  gactcaccc  gaaaattct  caacctgct  cacgactac  420
aaactcttc  aatgctttt  aacgcccac  atttgttct  cattcatcc  accaacttt  480
cactgcaca  cttctctct  taccggcgc  caggcaagg  gccacttct  atctgtatg  540
taattattt  gccacatgg  caaaagtaa  aatgctttc  gacaggaaa  taacaggcc  600
gaagtcgaa  atggaaatt  ataagttga  accactaaa  gacagggaa  acgggcatg  660
gtacagcgc  ctgccgggc  ggtgaagtg  agcctccat  aaaaggcag  agacagaca  720
cgccgggct  cgagtcccg  ctgtgctgc  tgcatcagg  tcacgctcc  ttagagacc  780
catcgctgc  gcagaagag  ctcggaagc  tcctgctga  ttaccctgt  tcaggctgc  840
tccttgaag  aacacaaaa  atatccact  ccccaaatc  taaggtggg  gggaacttc  900
ctgctgatc  agatatttt  caagctaca  ctgtggatt  aaccagtaa  ttctaacct  960
cctgtgtat  aagcttgca  cagtcagac  cgagtggag  tgtgtgcag  atgctgctt  1020
ccttgtacc  acaggcccc  aaatctcta  agcagaatg  gtatcatga  cagtgctgt  1080
tttaatgta  tagatgaga  ctgtaaata  cggagtcag  ctgttagca  ctaccagct  1140
ggcaatata  ctaaaaata  ctctcgtat  attgatgtt  tggtaaatt  atgctgtgg  1200
caaagaaac  tcacagaag  aagctgaac  tacagtatt  tagatggca  tgctggtta  1260
catccaagc  aaacaaaaa  aggttccaa  acctgtcac  tcttaaaat  aaagaatgg  1320
gacacaaga  ttaactcta  ccaattctt  aaatcgttt  cgggttgcc  acctcacta  1380
attattctg  ttcagtatg  gcttcttgc  tcgttttct  ttaaaacaa  agctatgaa  1440
ctacttgtc  aagaaagtt  aaacatttt  cacctttta  tattgtttg  agaaaaaaa  1500
atagaaaaa  ttttctttg  aaagacaag  cctaatatg  tttttaaaa  agctaaggg  1560
acatagata  ctgatgttc  ttagcattt  tttctggct  aaaaaagtg  tgattttat  1620
agtggcttc  tgagtcaag  cacagatgt  ttactctgg  ggtgaccat  ccgtttcac  1680
ctctgcaaa  ctctctcct  taacactca  cgctatgaa  ggctacgtt  aatcataaa  1740
gctacttta  cacctccca  cctcgcccc  ggaaactag  cttgaatac  cagactcat  1800
tttaacaac  actccgggc  gcatgcaga  atagcagtg  ccacaatgg  attacactg  1860
aggagaagc  cttttgaga  agggtccat  gttggcgcg  tcacacgcc  aaccaagag  1920
ctttaggaa  tgttgtgta  gcaatcaaa  gagagctgg  gataggcag  caggtggag  1980
aacaactat  tttgaagta  ttaagagaa  aactgggag  tgcaaccac  aggcaaatt  2040
agaaaaaaa  aaatcctat  taaccttta  aataaaagg  aagaggtac  tttttgtgg  2100
agagctggt  gccatcaag  caaatcctg  tccgcagtc  gcttctcac  cacgcaggg  2160
tctgtctgc  gtggagaga  catcgcacg  gctggtcac  gttccctct  tgtttccat  2220
ccattcacc  ctaccctct  gcgcccgca  tccaccagc  cactatcca  agtgagtga  2280
agtcgagag  agaacagca  gagggagca  ccactgcag  ctttccaca  agcatagct  2340
tgactgtgg  ttccgtggg  agactgaca  agaagcccc  agttaccag  aacaccctc  2400
tccagctct  agaggtaat  cctctgaag  ccgagctct  ccctgatgt  ttgggacca  2460
acttactgg  tactataga  gctgcaatt  ccttcccat  gagccctgc  agacaccac  2520
gcagtctga  agcaaggaa  gctttaaga  aatgtcctg  accattcca  cttctcaca  2580
cacaatact  cttacagta  gactaaaat  ttccccccc  ccaactttt  caataatca  2640
cacgtgggg  gcagagatt  ttttaaaag  ggtacatgg  aggaaaatt  tcctagcag  2700
acagcctaa  acagcaatg  ttatcactc  ttctctatc  aataaataa  cattcatgc  2760
ttctttcta  ttttataac  cctggctta  attttctct  ccatctctg  ttacttcta  2820
agataccct  aggactcat  atgatgtca  agccaaaaa  acttccatt  tagaaacat  2880
catagaaaa  tcactgtgt  tgcttgaac  atgcaggtg  gaaagaaac  cagagagaa  2940
agagggtgg  aaaacagac  aacagggac  aagttaaag  gagaggggg  agaagagag  3000
gaaaggaaa  tggggagaa  gagagagaa  agacaagac  caaagatat  acaaacaga  3060
ccacattgc  ttgaaatag  ccactgatg  aaaaaatgg  tagctgttg  ctttaaata  3120
tctaatatc  gaaaaaatc  tgcaataaa  tactataaa  gtag  3164



<210> 8817
<211> 1192
<212> PRT
<213> Homo sapiens
<308> AAF14051
<400> 8817

Met Glu Val Asp Thr Glu Glu Lys Arg His Arg Thr Arg Ser Lys Gly 
  1               5                  10                  15
Val Arg Val Pro Val Glu Pro Ala Ile Gln Glu Leu Phe Ser Cys Pro 
             20                  25                  30
Thr Pro Gly Cys Asp Gly Ser Gly His Val Ser Gly Lys Tyr Ala Arg 
         35                  40                  45
His Arg Ser Val Tyr Gly Cys Pro Leu Ala Lys Lys Arg Lys Thr Gln 
     50                  55                  60
Asp Lys Gln Pro Gln Glu Pro Ala Pro Lys Arg Lys Pro Phe Ala Val 
 65                  70                  75                  80
Lys Ala Asp Ser Ser Ser Val Asp Glu Cys Asp Asp Ser Asp Gly Thr 
                 85                  90                  95
Glu Asp Met Asp Glu Lys Glu Glu Asp Glu Gly Glu Glu Tyr Ser Glu 
             100                105                110
Asp Asn Asp Glu Pro Gly Asp Glu Asp Glu Glu Asp Glu Glu Gly Asp 
         115                120                125
Arg Glu Glu Glu Glu Glu Ile Glu Glu Glu Asp Glu Asp Asp Asp Glu 
     130                135                140
Asp Gly Glu Asp Val Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu 
 145                150                155                160
Glu Glu Glu Glu Glu Glu Glu Asn Glu Asp His Gln Met Asn Cys His 
                 165                170                175
Asn Thr Arg Ile Met Gln Asp Thr Glu Lys Asp Asp Asn Asn Ser Asp 
             180                185                190
Glu Tyr Asp Asn Tyr Asp Glu Leu Val Ala Lys Ser Leu Leu Asn Leu 
         195                200                205
Gly Lys Ile Ala Glu Asp Ala Ala Tyr Arg Ala Arg Thr Glu Ser Glu 
     210                215                220
Met Asn Ser Asn Thr Ser Asn Ser Leu Glu Asp Asp Ser Asp Lys Asn 
 225                230                235                240
Glu Asn Leu Gly Arg Lys Ser Glu Leu Ser Leu Asp Leu Asp Ser Asp 
                 245                250                255
Val Val Arg Glu Thr Val Asp Ser Leu Lys Leu Leu Ala Gln Gly His 
             260                265                270
Gly Val Val Leu Ser Glu Asn Met Asn Asp Arg Asn Tyr Ala Asp Ser 
         275                280                285
Met Ser Gln Gln Asp Ser Arg Asn Met Asn Tyr Val Met Leu Gly Lys 
     290                295                300
Pro Met Asn Asn Gly Leu Met Glu Lys Met Val Glu Glu Ser Asp Glu 
 305                310                315                320
Glu Val Cys Leu Ser Ser Leu Glu Cys Leu Arg Asn Gln Cys Phe Asp 
                 325                330                335
Leu Ala Arg Lys Leu Ser Glu Thr Asn Pro Gln Glu Arg Asn Pro Gln 
             340                345                350
Gln Asn Met Asn Ile Arg Gln His Val Arg Pro Glu Glu Asp Phe Pro 
         355                360                365
Gly Arg Thr Pro Asp Arg Asn Tyr Ser Asp Met Leu Asn Leu Met Arg 
     370                375                380
Leu Glu Glu Gln Leu Ser Pro Arg Ser Arg Val Phe Ala Ser Cys Ala 
 385                390                395                400
Lys Glu Asp Gly Cys His Glu Arg Asp Asp Asp Thr Thr Ser Val Asn 
                 405                410                415
Ser Asp Arg Ser Glu Glu Val Phe Asp Met Thr Lys Gly Asn Leu Thr 
             420                425                430
Leu Leu Glu Lys Ala Ile Ala Leu Glu Thr Glu Arg Ala Lys Ala Met 
         435                440                445
Arg Glu Lys Met Ala Met Glu Ala Gly Arg Arg Asp Asn Met Arg Ser 
     450                455                460
Tyr Glu Asp Gln Ser Pro Arg Gln Leu Pro Gly Glu Asp Arg Lys Pro 
 465                470                475                480
Lys Ser Ser Asp Ser His Val Lys Lys Pro Tyr Tyr Gly Lys Asp Pro 
                 485                490                495
Ser Arg Thr Glu Lys Lys Glu Ser Lys Cys Pro Thr Pro Gly Cys Asp 
             500                505                510
Gly Thr Gly His Val Thr Gly Leu Tyr Pro His His Arg Ser Leu Ser 
         515                520                525
Gly Cys Pro His Lys Asp Arg Val Pro Pro Glu Ile Leu Ala Met His 
     530                535                540
Glu Ser Val Leu Lys Cys Pro Thr Pro Gly Cys Thr Gly Arg Gly His 
 545                550                555                560
Val Asn Ser Asn Arg Asn Ser His Arg Ser Leu Ser Gly Cys Pro Ile 
                 565                570                575
Ala Ala Ala Glu Lys Leu Ala Lys Ala Gln Glu Lys His Gln Ser Cys 
             580                585                590
Asp Val Ser Lys Ser Ser Gln Ala Ser Asp Arg Val Leu Arg Pro Met 
         595                600                605
Cys Phe Val Lys Gln Leu Glu Ile Pro Gln Tyr Gly Tyr Arg Asn Asn 
     610                615                620
Val Pro Thr Thr Thr Pro Arg Ser Asn Leu Ala Lys Glu Leu Glu Lys 
 625                630                635                640
Tyr Ser Lys Thr Ser Phe Glu Tyr Asn Ser Tyr Asp Asn His Thr Tyr 
                 645                650                655
Gly Lys Arg Ala Ile Ala Pro Lys Val Gln Thr Arg Asp Ile Ser Pro 
             660                665                670
Lys Gly Tyr Asp Asp Ala Lys Arg Tyr Cys Lys Asp Pro Ser Pro Ser 
         675                680                685
Ser Ser Ser Thr Ser Ser Tyr Ala Pro Ser Ser Ser Ser Asn Leu Ser 
     690                695                700
Cys Gly Gly Gly Ser Ser Ala Ser Ser Thr Cys Ser Lys Ser Ser Phe 
 705                710                715                720
Asp Tyr Thr His Asp Met Glu Ala Ala His Met Ala Ala Thr Ala Ile 
                 725                730                735
Leu Asn Leu Ser Thr Arg Cys Arg Glu Met Pro Gln Asn Leu Ser Thr 
             740                745                750
Lys Pro Gln Asp Leu Cys Ala Thr Arg Asn Pro Asp Met Glu Val Asp 
         755                760                765
Glu Asn Gly Thr Leu Asp Leu Ser Met Asn Lys Gln Arg Pro Arg Asp 
     770                775                780
Ser Cys Cys Pro Ile Leu Thr Pro Leu Glu Pro Met Ser Pro Gln Gln 
 785                790                795                800
Gln Ala Val Met Asn Asn Arg Cys Phe Gln Leu Gly Glu Gly Asp Cys 
                 805                810                815
Trp Asp Leu Pro Val Asp Tyr Thr Lys Met Lys Pro Arg Arg Ile Asp 
             820                825                830
Glu Asp Glu Ser Lys Asp Ile Thr Pro Glu Asp Leu Asp Pro Phe Gln 
         835                840                845
Glu Ala Leu Glu Glu Arg Arg Tyr Pro Gly Glu Val Thr Ile Pro Ser 
     850                855                860
Pro Lys Pro Lys Tyr Pro Gln Cys Lys Glu Ser Lys Lys Asp Leu Ile 
 865                870                875                880
Thr Leu Ser Gly Cys Pro Leu Ala Asp Lys Ser Ile Arg Ser Met Leu 
                 885                890                895
Ala Thr Ser Ser Gln Glu Leu Lys Cys Pro Thr Pro Gly Cys Asp Gly 
             900                905                910
Ser Gly His Ile Thr Gly Asn Tyr Ala Ser His Arg Ser Leu Ser Gly 
         915                920                925
Cys Pro Arg Ala Lys Lys Arg Gly Ile Arg Ile Ala Gln Ser Lys Glu 
     930                935                940
Asp Lys Glu Asp Gln Glu Pro Ile Arg Cys Pro Val Pro Gly Cys Asp 
 945                950                955                960
Gly Gln Gly His Ile Thr Gly Lys Tyr Ala Ser His Arg Ser Ala Ser 
                 965                970                975
Gly Cys Pro Leu Ala Ala Lys Arg Gln Lys Glu Gly Tyr Leu Asn Gly 
             980                985                990
Ser Gln Phe Ser Trp Lys Ser Val Lys Thr Glu Gly Met Ser Cys Pro 
         995                1000                1005
Thr Pro Gly Cys Asp Gly Ser Gly His Val Ser Gly Ser Phe Leu Thr 
     1010                1015                1020
His Arg Ser Leu Ser Gly Cys Pro Arg Ala Thr Ser Ala Met Lys Lys 
 1025                1030                1035                1040
Ala Lys Leu Ser Gly Glu Gln Met Leu Thr Ile Lys Gln Arg Ala Ser 
                 1045                1050                1055
Asn Gly Ile Glu Asn Asp Glu Glu Ile Lys Gln Leu Asp Glu Glu Ile 
             1060                1065                1070
Lys Glu Leu Asn Glu Ser Asn Ser Gln Met Glu Ala Asp Met Ile Lys 
         1075                1080                1085
Leu Arg Thr Gln Ile Thr Thr Met Glu Ser Asn Leu Lys Thr Ile Glu 
     1090                1095                1100
Glu Glu Asn Lys Val Val Glu Gln Gln Asn Glu Ser Leu Leu His Glu 
 1105                1110                1115                1120
Leu Ala Asn Leu Ser Gln Ser Leu Ile His Ser Leu Ala Asn Ile Gln 
                 1125                1130                1135
Leu Pro His Met Asp Pro Ile Asn Glu Gln Asn Phe Asp Ala Tyr Val 
             1140                1145                1150
Thr Thr Leu Thr Glu Met Tyr Thr Asn Gln Asp Arg Tyr Gln Ser Pro 
         1155                1160                1165
Glu Asn Lys Ala Leu Leu Glu Asn Ile Lys Gln Ala Val Arg Gly Ile 
     1170                1175                1180
Gln Phe Arg Ser Glu Gln Leu Leu 
 1185                1190



<210> 8818
<211> 3348
<212> DNA
<213> Rattus norvegicus
<308> U67140
<400> 8818

gaattcggc  cgagcggca  cgtgctgga  ggatgtgtg  cgcagtcct  agtcccaca  60
ccgcttccg  ggtgtcatc  gcagcatac  tgccggcta  catttttcc  gtgcacgcg  120
ctccctggt  ggacagctg  tgcctggga  aggtgacac  agtgcccaa  tagggcaaa  180
gcccccgcc  cgtgggcca  gatcatgaa  ggcctcggt  acagccgcc  ccgccacct  240
tccgacagc  tggacccac  tcatgagcc  ctctttgcc  ggcctgacc  caaccccta  300
ctgctgtcg  ccaccgagg  ctttgcccg  gaagcccgt  tccctgggc  aaacacact  360
ccgggggat  ggctcttcc  actcaacaa  cagctgccc  caccaagca  cacctttcc  420
cggatccac  ataactccc  ctttgaggt  cccgaggaa  gtccgttcc  cagccatgc  480
caagccacc  agatcaacc  gctgcctgc  aacctcctg  accagtttg  gaaacaact  540
cctatccac  gggatggtt  cagcaccct  cagttcccc  ggggcgagg  caaggcccg  600
ggtgagagt  ctggccgca  tcgccacct  gtccactcc  tccagcgtc  cttcttcac  660
aaggcaccc  cgatggagg  caccacggg  aaggtgggt  gcaacggcg  caagaaagg  720
gtcctggag  acgggaaag  ccggagggc  aaaagcaag  aacgggcca  ggctgggga  780
cccaaacgg  gaagccgct  caacatctc  ggctggtgg  gttccgatg  caacctgga  840
ggtgagggt  gtgccttcc  cagcggccc  gcctcgggg  tgatgactc  gggccgcca  900
ccagaacgt  cccagcccc  ctacttcat  cacgcctac  acaccatca  cggacacat  960
ctcaaaacc  ccaagaaca  taccaccga  ctgactgcc  caccacccc  gcctgctcc  1020
cctgctacc  gtcccagcc  tggagtggg  actgacacc  actatgtca  acgtggttc  1080
tggtccact  tgaccctca  ccatgccca  gaggtctgc  agaagacct  agccacttt  1140
gataagagc  tgctgaagt  caaatcctg  caccagggt  tggcctacc  ttacttgca  1200
gtgcccggc  gagggggag  gtggagcac  acgctgctg  cccctcgag  tatggatag  1260
accgctgag  ggccgatcc  gtgccggcg  atgcgcagt  gcagctata  caaggccat  1320
ggcgacgaa  acagtgatg  gtctggagg  ggtagcccc  agccttctc  caagactgc  1380
gcacggcgt  agagctatc  gagggccac  cagcagtcc  tgggagagc  gagcaaccc  1440
cgcaggagc  tggaccgct  ggattcagt  gacatgccg  tgccgtcca  gtaccccag  1500
tgggaagag  actacaacc  catcagtga  agcctcaat  actccggct  tatcagcca  1560
gtttttgga  aggcttccc  gatccctca  ttgtttggc  atgatcaac  ggtccggga  1620
gcagacctg  gtgaccagt  tgaggcagc  tgtgagtcg  cctgcagtg  ggctgagtc  1680
acagccgca  aggcgctcg  cttgtcgct  cccagctac  tccgctcac  cagccacag  1740
tacctgcga  ccatccagg  gggctgctc  caggaggag  acagtgtct  cctgcagtc  1800
ctctcccca  cgcccagca  cggcagcct  agcaacagc  gtacacttc  aagttcatc  1860
tgcctagtg  catataaga  gaccccacc  ccggtccct  cacgtacca  atcgaaacc  1920
ttcatctca  ttaccgttc  gagcagtac  gagtctgct  aggacacct  cctggacag  1980
caagaccac  agagtgaag  gacaagcca  tcgggcttg  gtaactcat  agacagcct  2040
gacagcagt  cccggccac  cagtgtgac  cggggtgga  ttacgccag  ccctgaggc  2100
ccagagcca  cccctaagc  tgcagctct  aagagtgaa  acgggacac  gacgagctc  2160
gagtcccac  ccgaggccg  ccccaaaag  aaactgtca  caataggaa  acaagttga  2220
tgcattcag  cagtgccaa  agaggagcc  agtcccgct  ccaaattcc  gtccatcgg  2280
gttcaggta  aggacgact  gcgaagcag  gccccctct  acagcatgt  ctcccgtcg  2340
gacactgac  ccgataccc  ggacgccaa  gactccagt  gtaagtcat  tgagaggag  2400
ctcccagac  gtacctcac  ccccaattc  atcagcatt  atgctggcc  ccgacaggc  2460
cccaagatt  cccagatca  gcgcaacct  tcctatgga  acaacagcg  ccctgccct  2520
gaggcatct  cgctgcccc  acccgaccc  tggatggag  cttcctcca  ctccccagc  2580
gagccagct  agccagggg  ctgccgcag  gatggctac  ggttcctga  gctccttca  2640
gctgaaacg  agaggctgg  aggatggtg  tgtcagatg  acaaggaga  caaagagaa  2700
aacctctct  aagaagtct  aggaaaagt  ctcagtgct  tgggcagcg  ccagctcct  2760
atgtcccag  aattccaac  gttccgtgg  atttgtgag  agaacttga  ccctgatgc  2820
aacccccgt  cgacagccc  ggacctggc  gggttctgg  acctgctgc  gctgtccat  2880
gaggacatc  gcatgaagt  cgatgagct  taccacctc  aggccaaca  ctggcagct  2940
gtggagacc  ccgagaaga  gaaggaaga  aagaaacca  cccctccag  cccgaagaa  3000
ccagccaaa  ccaaggcgg  agtgagccg  gacaaggcc  cagatgcgg  ggacaagca  3060
cggcaggag  ccagaaaga  actcctggc  gccaagcgg  cagcatctg  gcggcagaa  3120
tcggccaca  agagtgcag  cagcatcga  atttatgtc  ctgaggccc  gaccaggct  3180
taaggccac  aaggagaaa  cactcattt  aaatcatta  aaactcaat  caaacggaa  3240
agcgtttct  accctttgg  atggttatt  tctctagag  ccctgagcc  actttccaa  3300
tgacacgta  aagggctca  aaggtggct  ttctctcgt  ccgaattc  3348



<210> 8819
<211> 992
<212> PRT
<213> Rattus norvegicus
<308> P97839
<400> 8819

Met Lys Gly Leu Gly Asp Ser Arg Pro Arg His Leu Ser Asp Ser Leu 
  1               5                  10                  15
Asp Pro Pro His Glu Pro Leu Phe Ala Gly Pro Asp Arg Asn Pro Tyr 
             20                  25                  30
Leu Leu Ser Pro Thr Glu Ala Phe Ala Arg Glu Ala Arg Phe Pro Gly 
         35                  40                  45
Gln Asn Thr Leu Pro Gly Asp Gly Leu Phe Pro Leu Asn Asn Gln Leu 
     50                  55                  60
Pro Pro Pro Ser Ser Thr Phe Pro Arg Ile His Tyr Asn Ser His Phe 
 65                  70                  75                  80
Glu Val Pro Glu Glu Ser Pro Phe Pro Ser His Ala Gln Ala Thr Lys 
                 85                  90                  95
Ile Asn Arg Leu Pro Ala Asn Leu Leu Asp Gln Phe Glu Lys Gln Leu 
             100                105                110
Pro Ile His Arg Asp Gly Phe Ser Thr Leu Gln Phe Pro Arg Gly Glu 
         115                120                125
Ala Lys Ala Arg Gly Glu Ser Pro Gly Arg Ile Arg His Leu Val His 
     130                135                140
Ser Val Gln Arg Leu Phe Phe Thr Lys Ala Pro Ser Met Glu Gly Thr 
 145                150                155                160
Thr Gly Lys Val Gly Gly Asn Gly Gly Lys Lys Gly Val Leu Glu Asp 
                 165                170                175
Gly Lys Gly Arg Arg Ala Lys Ser Lys Glu Arg Ala Lys Ala Gly Glu 
             180                185                190
Pro Lys Arg Arg Ser Arg Ser Asn Ile Ser Gly Trp Trp Ser Ser Asp 
         195                200                205
Asp Asn Leu Asp Gly Glu Gly Gly Ala Phe Arg Ser Gly Pro Ala Ser 
     210                215                220
Gly Leu Met Thr Leu Gly Arg Gln Pro Glu Arg Thr Gln Pro Arg Tyr 
 225                230                235                240
Phe Met His Ala Tyr Asn Thr Ile Ser Gly His Met Leu Lys Thr Thr 
                 245                250                255
Lys Asn Thr Thr Thr Glu Leu Thr Ala Pro Pro Pro Pro Pro Ala Pro 
             260                265                270
Pro Ala Thr Cys Pro Ser Leu Gly Val Gly Thr Asp Thr Asn Tyr Val 
         275                280                285
Lys Arg Gly Ser Trp Ser Thr Leu Thr Leu Ser His Ala His Glu Val 
     290                295                300
Cys Gln Lys Thr Ser Ala Thr Leu Asp Lys Ser Leu Leu Lys Ser Lys 
 305                310                315                320
Ser Cys His Gln Gly Leu Ala Tyr His Tyr Leu Gln Val Pro Gly Gly 
                 325                330                335
Gly Gly Glu Trp Ser Thr Thr Leu Leu Ser Pro Arg Asp Met Asp Ser 
             340                345                350
Thr Ala Glu Gly Pro Ile Pro Cys Arg Arg Met Arg Ser Gly Ser Tyr 
         355                360                365
Ile Lys Ala Met Gly Asp Glu Asp Ser Asp Glu Ser Gly Gly Gly Ser 
     370                375                380
Pro Lys Pro Ser Pro Lys Thr Ala Ala Arg Arg Gln Ser Tyr Leu Arg 
 385                390                395                400
Ala Thr Gln Gln Ser Leu Gly Glu Gln Ser Asn Pro Arg Arg Ser Leu 
                 405                410                415
Asp Arg Leu Asp Ser Val Asp Met Pro Leu Pro Ser Lys Tyr Pro Ser 
             420                425                430
Trp Glu Glu Asp Tyr Asn Pro Ile Ser Asp Ser Leu Asn Asp Ser Gly 
         435                440                445
Cys Ile Ser Gln Val Phe Gly Gln Ala Ser Leu Ile Pro Gln Leu Phe 
     450                455                460
Gly His Asp Gln Gln Val Arg Glu Ala Asp Leu Ser Asp Gln Tyr Glu 
 465                470                475                480
Ala Ala Cys Glu Ser Ala Cys Ser Glu Ala Glu Ser Thr Ala Ala Glu 
                 485                490                495
Ala Leu Asp Leu Ser Leu Pro Ser Tyr Phe Arg Ser Arg Ser His Ser 
             500                505                510
Tyr Leu Arg Ala Ile Gln Ala Gly Cys Ser Gln Glu Glu Asp Ser Val 
         515                520                525
Ser Leu Gln Ser Leu Ser Pro Pro Pro Ser Thr Gly Ser Leu Ser Asn 
     530                535                540
Ser Arg Thr Leu Pro Ser Ser Ser Cys Leu Val Ala Tyr Lys Lys Thr 
 545                550                555                560
Pro Pro Pro Val Pro Pro Arg Thr Thr Ser Lys Pro Phe Ile Ser Val 
                 565                570                575
Thr Val Gln Ser Ser Thr Glu Ser Ala Gln Asp Thr Tyr Leu Asp Ser 
             580                585                590
Gln Asp His Lys Ser Glu Val Thr Ser Gln Ser Gly Leu Ser Asn Ser 
         595                600                605
Ser Asp Ser Leu Asp Ser Ser Thr Arg Pro Pro Ser Val Thr Arg Gly 
     610                615                620
Gly Ile Thr Pro Gly Pro Glu Ala Pro Glu Pro Pro Pro Lys His Ala 
 625                630                635                640
Ala Leu Lys Ser Glu His Gly Thr Leu Thr Ser Ser Glu Ser His Ser 
                 645                650                655
Glu Ala Val Pro Lys Arg Lys Leu Ser Ser Ile Gly Ile Gln Val Asp 
             660                665                670
Cys Ile Gln Pro Val Pro Lys Glu Glu Pro Ser Pro Ala Thr Lys Phe 
         675                680                685
Gln Ser Ile Gly Val Gln Val Glu Asp Asp Trp Arg Ser Ser Ala Pro 
     690                695                700
Ser His Ser Met Ser Ser Arg Arg Asp Thr Asp Ser Asp Thr Gln Asp 
 705                710                715                720
Ala Asn Asp Ser Ser Cys Lys Ser Ser Glu Arg Ser Leu Pro Asp Cys 
                 725                730                735
Thr Ser His Pro Asn Ser Ile Ser Ile Asp Ala Gly Pro Arg Gln Ala 
             740                745                750
Pro Lys Ile Ala Gln Ile Lys Arg Asn Leu Ser Tyr Gly Asp Asn Ser 
         755                760                765
Asp Pro Ala Leu Glu Ala Ser Ser Leu Pro Pro Pro Asp Pro Trp Met 
     770                775                780
Glu Thr Ser Ser Ser Ser Pro Ala Glu Pro Ala Gln Pro Gly Ala Cys 
 785                790                795                800
Arg Arg Asp Gly Tyr Trp Phe Leu Lys Leu Leu Gln Ala Glu Thr Glu 
                 805                810                815
Arg Leu Glu Gly Trp Cys Cys Gln Met Asp Lys Glu Thr Lys Glu Asn 
             820                825                830
Asn Leu Ser Glu Glu Val Leu Gly Lys Val Leu Ser Ala Val Gly Ser 
         835                840                845
Ala Gln Leu Leu Met Ser Gln Lys Phe Gln Gln Phe Arg Gly Ile Cys 
     850                855                860
Glu Gln Asn Leu Asn Pro Asp Ala Asn Pro Arg Pro Thr Ala Gln Asp 
 865                870                875                880
Leu Ala Gly Phe Trp Asp Leu Leu Gln Leu Ser Ile Glu Asp Ile Ser 
                 885                890                895
Met Lys Phe Asp Glu Leu Tyr His Leu Lys Ala Asn Ser Trp Gln Leu 
             900                905                910
Val Glu Thr Pro Glu Lys Arg Lys Glu Glu Lys Lys Pro Pro Pro Pro 
         915                920                925
Val Pro Lys Lys Pro Ala Lys Ser Lys Ala Ala Val Ser Arg Asp Lys 
     930                935                940
Ala Ser Asp Ala Gly Asp Lys Gln Arg Gln Glu Ala Arg Lys Arg Leu 
 945                950                955                960
Leu Ala Ala Lys Arg Ala Ala Ser Val Arg Gln Asn Ser Ala Thr Glu 
                 965                970                975
Ser Ala Asp Ser Ile Glu Ile Tyr Val Pro Glu Ala Gln Thr Arg Leu 
             980                985                990



<210> 8820
<211> 556
<212> DNA
<213> Rattus norvegicus
<308> U67207
<400> 8820

ggaaatcag  ccaatctca  tttcctgtg  gcagaatca  cacacactg  tacagttct  60
gccatcaat  ccatcggtg  ctcccttgt  aattttaac  ttacgttct  atggcccat  120
agtaaagtg  atgctgtgc  gtcactcag  gcttatccc  tgagcagca  ctcgctcat  180
ctttcctgg  cactgtcac  taatgatta  agtctgtta  atctggtta  tgaatggaa  240
aaccttaat  atgatgatg  aatgaagtg  cttagaatc  cttcgaatg  taacaagta  300
tatatccat  ataatttta  tcctatcga  aaatatcag  ttagtcttt  cccagtatt  360
atggaagga  ttggaaaac  aaagataat  aatggtttc  ccaaagatg  tatcgccaa  420
cagcaaaat  atgcagggc  gtatgtcat  gtaccgata  ttatttcct  ttgtgtcct  480
ctgctcgga  cactgttaa  ttcacacca  agaatgaaa  agttgtttt  ggacgatgt  540
ccaaacccc  agaatt  556



<210> 8821
<211> 2991
<212> DNA
<213> Homo sapiens
<308> U52912
<400> 8821

gcgcgcgcg  cgcaggtgc  cgagccccg  cccgcgccc  tctctgcct  cggtcgagt  60
ggacccccg  atcaaggtg  acttctctg  agtaagatg  tttgtcaaa  attctgtgt  120
gttttgtta  attgggaat  tatttatgt  ataactgcg  ttaacttgt  atatccaat  180
actccttgg  gatttaagt  gtcttgcat  ccaccaaat  caacctatg  ctacttcct  240
ttgcctgct  gactctcaa  gaatacttc  aattcgaat  gacattatg  gacagctgt  300
gaacctaag  ttaattcaa  tggtactca  ttttctaac  tatccaaag  aactttcca  360
tgttgcttt  ggagtgagc  agatagaaa  tgctcctta  gtgcagaca  cattgaagg  420
aggacattt  tttcaacag  aaattcttt  gtttttcaa  aaatagatg  aaactggaa  480
atacagtgc  ggctaaaag  agacttaaa  ttattcatc  gttatgtgg  gtcattatt  540
aagaatcta  tcaggaatt  taactataa  gtccatctt  tatatgttc  gcctgaagt  600
ttagaagat  cacctctgg  tccccaaaa  ggcagtttt  agatggttc  ctgcaattg  660
agtgttcat  aatgttgtg  atgtcttgt  cctgtgcca  cagccaaac  caacgacac  720
ctccttatg  gtttgaaaa  cacatctgg  ggagtaatt  tccggtcac  tctaatgtc  780
gttcagccc  taaatatgg  gaagcctga  ccaccatta  gtttgcata  ggaaatcac  840
gatgatggt  atttaaaga  ttcttggtc  agcccacca  tggtaccat  tccacttca  900
tatcaagtg  aatattcag  gaattctac  acagttatc  gagaagctg  caagattgt  960
tcagctaca  ccctgctag  agacagtat  cttcctggg  cttcgtatg  ggttcaggt  1020
aggggcaag  gactggatg  cccaggaat  tggagtgac  ggagtactc  tcgtgtctt  1080
accacacaa  atgtcatat  ctttccacc  aaaattctg  caagtgttg  gtctaatgt  1140
tcttttcac  gcatctata  gaaggaaaa  aagattgtt  cctcaaaag  gattgtttg  1200
tggatgaat  tagctgaga  aattcctca  agccagtat  atgttgtga  tgatcatgt  1260
agcaaagtt  cttttttca  tctgaatga  accaaacct  gaggaaagt  tacctatga  1320
gcagtgtac  gctgcaatg  acatgaatg  catcatcgc  atgctgaat  atatgtgat  1380
gatgtcaat  tcaatatct  atgtgaaac  gatgggtac  taactaaaa  gacttgcag  1440
tggtcaacc  gtacaatcc  gtcacttgc  gaaagcact  tgcaattga  gtatcatag  1500
agcagcctt  actgttctg  tattccatc  attcatccc  tatctgagc  caaagattg  1560
tatttgcag  gtgatggtt  ttatgaatg  attttccag  caatcttcc  attatctgg  1620
tacacaatg  ggattagga  caatcactc  ctaggttca  ttgactctc  accaacatg  1680
gtccttcct  attctgtgg  gaagccact  cctccatcc  gtgtgaaag  agaaattac  1740
ataaacatt  gattattga  aatatcttg  gaaaagcca  tctttccag  gaataacct  1800
caattccag  ttcgctatg  tttaagtgg  aaagaagta  aatggaaga  gtatgaggt  1860
tatgatgca  aatcaaaat  tgtcagtct  ccagttcca  acttgtgtg  agtctatgc  1920
gttcaggtg  gctgtaaga  gctagatgg  ctgggatat  ggagtaatt  gagcaatcc  1980
gcctacaca  ttgtcatgg  tataaaagt  cctatgaga  gacctgaat  ttggagaat  2040
attaatgga  atactatga  aaaggagaa  aatgtcact  tactttgga  gcccctgat  2100
aaaaatgac  cattgtgca  tgttcagag  tatgtgata  accatcata  ttcctgcaa  2160
ggaacatgg  cagaagatg  gggaaatca  acgaaattc  ctttcctgt  gacagagca  2220
gcacatact  ttacggttc  ggccatcaa  tcaattggt  cttctgttg  aaattttaa  2280
ttaaccttt  catggccta  gagcaaagt  aatatcgtg  agtcactca  tgcttatcc  2340
ttaaacagc  gttgtgtga  tgtttcctg  atactatca  ccagtgatt  caagctaat  2400
tattttatt  ttgagtgga  aaatcttaa  gaagatggt  aaataaaat  gcttagaat  2460
tcttcatct  ttaagaagt  ttatatcca  gatcatttt  tccccattg  gaagtacca  2520
ttcagtctt  acccaatat  tatggaagg  gtgggaaaa  caaagataa  taatagttt  2580
actcaagat  atattgaaa  acaccagag  gatgcaggt  tatatgtaa  tgtgccagt  2640
attatttcc  cttccatct  attgcttgg  acattatta  tatcacacc  aagaatgaa  2700
aagctattt  gggaagatg  tccgaaccc  aagaattgt  cctgggcac  aggacttaa  2760
tttcagaag  tgcttgaag  cagcatgtt  gttaagagt  atcaccact  cctaatctc  2820
agtacccag  gacacaaac  ctgcggaag  ccacagggt  ctctgcata  gaaaaccag  2880
gacctttgt  cacttgttt  tctgctgac  ctccctcca  tattgtcct  tgaccctgc  2940
aaatccccc  ctgtgagaa  cacccaaga  tgatcaata  aaaaaaaaa  a  2991



<210> 8822
<211> 1165
<212> PRT
<213> Homo sapiens
<308> P48357
<400> 8822

Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
  1               5                  10                  15
Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
             20                  25                  30
Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
         35                  40                  45
Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
     50                  55                  60
Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
 65                  70                  75                  80
Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                 85                  90                  95
Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
             100                105                110
Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
         115                120                125
Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
     130                135                140
Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
 145                150                155                160
Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                 165                170                175
Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
             180                185                190
Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
         195                200                205
Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
     210                215                220
Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
 225                230                235                240
Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                 245                250                255
Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
             260                265                270
Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
         275                280                285
Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
     290                295                300
Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
 305                310                315                320
Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                 325                330                335
Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
             340                345                350
Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
         355                360                365
Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
     370                375                380
Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
 385                390                395                400
Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                 405                410                415
Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
             420                425                430
Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
         435                440                445
Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
     450                455                460
Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
 465                470                475                480
Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                 485                490                495
Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
             500                505                510
Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
         515                520                525
Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
     530                535                540
Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
 545                550                555                560
Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                 565                570                575
Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
             580                585                590
Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
         595                600                605
Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
     610                615                620
Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
 625                630                635                640
Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                 645                650                655
Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
             660                665                670
Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
         675                680                685
Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
     690                695                700
Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
 705                710                715                720
Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                 725                730                735
Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
             740                745                750
Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
         755                760                765
Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
     770                775                780
Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
 785                790                795                800
Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                 805                810                815
Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
             820                825                830
Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
         835                840                845
Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
     850                855                860
Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
 865                870                875                880
Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Pro Glu Thr Phe Glu 
                 885                890                895
His Leu Phe Ile Lys His Thr Ala Ser Val Thr Cys Gly Pro Leu Leu 
             900                905                910
Leu Glu Pro Glu Thr Ile Ser Glu Asp Ile Ser Val Asp Thr Ser Trp 
         915                920                925
Lys Asn Lys Asp Glu Met Met Pro Thr Thr Val Val Ser Leu Leu Ser 
     930                935                940
Thr Thr Asp Leu Glu Lys Gly Ser Val Cys Ile Ser Asp Gln Phe Asn 
 945                950                955                960
Ser Val Asn Phe Ser Glu Ala Glu Gly Thr Glu Val Thr Tyr Glu Ala 
                 965                970                975
Glu Ser Gln Arg Gln Pro Phe Val Lys Tyr Ala Thr Leu Ile Ser Asn 
             980                985                990
Ser Lys Pro Ser Glu Thr Gly Glu Glu Gln Gly Leu Ile Asn Ser Ser 
         995                1000                1005
Val Thr Lys Cys Phe Ser Ser Lys Asn Ser Pro Leu Lys Asp Ser Phe 
     1010                1015                1020
Ser Asn Ser Ser Trp Glu Ile Glu Ala Gln Ala Phe Phe Ile Leu Ser 
 1025                1030                1035                1040
Asp Gln His Pro Asn Ile Ile Ser Pro His Leu Thr Phe Ser Glu Gly 
                 1045                1050                1055
Leu Asp Glu Leu Leu Lys Leu Glu Gly Asn Phe Pro Glu Glu Asn Asn 
             1060                1065                1070
Asp Lys Lys Ser Ile Tyr Tyr Leu Gly Val Thr Ser Ile Lys Lys Arg 
         1075                1080                1085
Glu Ser Gly Val Leu Leu Thr Asp Lys Ser Arg Val Ser Cys Pro Phe 
     1090                1095                1100
Pro Ala Pro Cys Leu Phe Thr Asp Ile Arg Val Leu Gln Asp Ser Cys 
 1105                1110                1115                1120
Ser His Phe Val Glu Asn Asn Ile Asn Leu Gly Thr Ser Ser Lys Lys 
                 1125                1130                1135
Thr Phe Ala Ser Tyr Met Pro Gln Phe Gln Thr Cys Ser Thr Gln Thr 
             1140                1145                1150
His Lys Ile Met Glu Asn Lys Met Cys Asp Leu Thr Val 
         1155                1160                1165



<210> 8823
<211> 1235
<212> DNA
<213> Rattus norvegicus
<308> U67910
<400> 8823

tagagaaga  caaagacag  tgaggtgat  tctcccaga  cctccgaca  ctgagtgtt  60
cgctgaagc  gagtggcca  gccactaga  acctcaagc  cctggaatg  acctaccct  120
ctgctccct  gttcctggc  tattctgca  accacaacc  gttgggcct  gccagccct  180
acctccaac  gggcccgta  tactcactg  gtccgaatg  tgaagctgc  gctgctgac  240
ctgcctctc  tgtccagcc  ggtgcacgc  gcccctagt  tagctatgc  acgagaggg  300
attgtgggg  gacaggagg  gtctgggaa  aagtggccc  ggcaggtga  cctgcgtgt  360
aatgacacc  actggatgc  tttctgcgg  ggctccctc  tccacccac  gtgggtgct  420
actgcggca  actgtgtgg  accgaataa  gctgacccc  acaagctca  ggtacagct  480
cgtaagcag  atctctatt  tcatgacca  ctgctgacc  tgagccaga  catctcaca  540
cctgacttc  acatcgccc  ggatggggc  gacattgcc  tgctgaaac  cactaaccc  600
gtgaacatt  ccagcaatg  ccacactgt  tccctgcct  ccgcctcag  gaccttccc  660
tcagggaca  tgtgctggg  gacaggctg  ggtaacatc  acaatgatg  aagcctgcc  720
ccgccattt  ctttggagg  ggtgcaagt  cccattgta  aaaaccgcc  ctgtgactt  780
aagtatcac  aaggtctca  cacaggtga  aacgtccac  ttgtccgtg  cgacatgct  840
tgtgctggg  atgaaggac  tgactcctg  cagggcgac  ccggaggac  tctggtctg  900
aaggttgaa  atacctggc  gcaggcagg  gttgtgagc  ggggtgagg  ctgcgcaca  960
cccaacagg  ctggcatct  cactcgggt  acctattac  tggactgga  ctaccgcta  1020
gtccccaag  acttctgag  tgcatccag  gtgacctct  ttgtttcca  catgctgct  1080
tctgcctcc  tgcttccct  ctccccagc  tgagcccca  ctctgctct  cctgagccc  1140
tgaccactt  tgtccctcc  gctcaggta  ccacactgt  caggcagcc  ctctgctat  1200
gctcaataa  atgcattaa  gcaaaaaaa  aaaaa  1235



<210> 8824
<211> 273
<212> PRT
<213> Rattus norvegicus
<308> P27435
<400> 8824

Met Leu Lys Leu Leu Leu Leu Thr Leu Pro Leu Leu Ser Ser Leu Val 
  1               5                  10                  15
His Ala Ala Pro Ser Leu Ala Met Pro Arg Glu Gly Ile Val Gly Gly 
             20                  25                  30
Gln Glu Ala Ser Gly Asn Lys Trp Pro Trp Gln Val Ser Leu Arg Val 
         35                  40                  45
Asn Asp Thr Tyr Trp Met His Phe Cys Gly Gly Ser Leu Ile His Pro 
     50                  55                  60
Gln Trp Val Leu Thr Ala Ala His Cys Val Gly Pro Asn Lys Ala Asp 
 65                  70                  75                  80
Pro Asn Lys Leu Arg Val Gln Leu Arg Lys Gln Tyr Leu Tyr Tyr His 
                 85                  90                  95
Asp His Leu Leu Thr Val Ser Gln Ile Ile Ser His Pro Asp Phe Tyr 
             100                105                110
Ile Ala Gln Asp Gly Ala Asp Ile Ala Leu Leu Lys Leu Thr Asn Pro 
         115                120                125
Val Asn Ile Thr Ser Asn Val His Thr Val Ser Leu Pro Pro Ala Ser 
     130                135                140
Glu Thr Phe Pro Ser Gly Thr Leu Cys Trp Val Thr Gly Trp Gly Asn 
 145                150                155                160
Ile Asn Asn Asp Val Ser Leu Pro Pro Pro Phe Pro Leu Glu Glu Val 
                 165                170                175
Gln Val Pro Ile Val Glu Asn Arg Leu Cys Asp Leu Lys Tyr His Lys 
             180                185                190
Gly Leu Asn Thr Gly Asp Asn Val His Ile Val Arg Asp Asp Met Leu 
         195                200                205
Cys Ala Gly Asn Glu Gly His Asp Ser Cys Gln Gly Asp Ser Gly Gly 
     210                215                220
Pro Leu Val Cys Lys Val Glu Asp Thr Trp Leu Gln Ala Gly Val Val 
 225                230                235                240
Ser Trp Gly Glu Gly Cys Ala Gln Pro Asn Arg Pro Gly Ile Tyr Thr 
                 245                250                255
Arg Val Thr Tyr Tyr Leu Asp Trp Ile Tyr Arg Tyr Val Pro Lys Tyr 
             260                265                270
Phe 
         275



<210> 8825
<211> 1154
<212> DNA
<213> Homo sapiens
<308> M30038
<400> 8825

ggaattccg  ggccaggat  ctgagcctg  tgctgctgg  gctgcccgt  ctggcgagc  60
gcgcctacg  ggcccctgc  ccagtccag  ccctgcagc  agcgggtat  gtcgggggt  120
aggaggccc  caggagcaa  tggccctgg  aggtgagcc  gagagtccg  gaccgatac  180
ggatgcact  ctgcggggg  tccctcatc  acccccagt  ggtgctgac  gcggcgcac  240
gcctgggac  ggacgtcaa  gatctggcc  ccctcaggg  gcaactgcg  gagcagcac  300
tctactacc  ggaccagct  ctgccagtc  gcaggatca  cgtgcaccc  cagttctac  360
tcatccaga  tggagcgga  atcgccctg  tggagctgg  ggagcccgt  aacatctcc  420
gccgcgtcc  cacggtcat  ctgccccct  cctcggaga  cttcccccc  gggatgccg  480
gctgggtca  tggctgggg  gatgtggac  atgatgagc  cctcccacc  ccatttccc  540
tgaagcagg  gaaggtccc  ataatggaa  accacattt  tgacgcaaa  taccacctt  600
gcgcctaca  gggagacga  gtccgcatc  tccgtgacg  catgctgtg  gccgggaac  660
gccagaggg  ctcctgcaa  ggcgactct  gagggcccc  ggtgtgcaa  gtgaatggc  720
cctggctac  ggcgggcgt  gtcagctgg  acgagggct  tgcccagcc  aaccggcct  780
gcatctaca  ccgtgtcac  tactacttg  actggatcc  ccactatgt  cccaaaaag  840
cgtgagtca  gcctgggtg  gccacctgg  tcactggag  accaacccc  gctgtccaa  900
acaccactg  ttcctaccc  ggtggcgac  gccccccac  ccttccctg  cccgtcctg  960
gtgcccctt  ctgtcctaa  ccccctgct  tcttctgag  cccttcccc  gtcctgagg  1020
cccttcccc  tcctgagcc  ccttccctg  cctaagcct  acgcctgca  tgctccggc  1080
ctcccctgc  caggcagct  gtggtgggc  ctaatcctc  tgagtgctg  acctcatta  1140
agtgcatgg  aatc  1154



<210> 8826
<211> 275
<212> PRT
<213> Homo sapiens
<308> P15157
<400> 8826

Met Leu Ser Leu Leu Leu Leu Ala Leu Pro Val Leu Ala Ser Arg Ala 
  1               5                  10                  15
Tyr Ala Ala Pro Ala Pro Val Gln Ala Leu Gln Gln Ala Gly Ile Val 
             20                  25                  30
Gly Gly Gln Glu Ala Pro Arg Ser Lys Trp Pro Trp Gln Val Ser Leu 
         35                  40                  45
Arg Val Arg Asp Arg Tyr Trp Met His Phe Cys Gly Gly Ser Leu Ile 
     50                  55                  60
His Pro Gln Trp Val Leu Thr Ala Ala His Cys Leu Gly Pro Asp Val 
 65                  70                  75                  80
Lys Asp Leu Ala Thr Leu Arg Val Gln Leu Arg Glu Gln His Leu Tyr 
                 85                  90                  95
Tyr Gln Asp Gln Leu Leu Pro Val Ser Arg Ile Ile Val His Pro Gln 
             100                105                110
Phe Tyr Ile Ile Gln Thr Gly Ala Asp Ile Ala Leu Leu Glu Leu Glu 
         115                120                125
Glu Pro Val Asn Ile Ser Ser Arg Val His Thr Val Met Leu Pro Pro 
     130                135                140
Ala Ser Glu Thr Phe Pro Pro Gly Met Pro Cys Trp Val Thr Gly Trp 
 145                150                155                160
Gly Asp Val Asp Asn Asp Glu Pro Leu Pro Pro Pro Phe Pro Leu Lys 
                 165                170                175
Gln Val Lys Val Pro Ile Met Glu Asn His Ile Cys Asp Ala Lys Tyr 
             180                185                190
His Leu Gly Ala Tyr Thr Gly Asp Asp Val Arg Ile Ile Arg Asp Asp 
         195                200                205
Met Leu Cys Ala Gly Asn Thr Arg Arg Asp Ser Cys Lys Gly Asp Ser 
     210                215                220
Gly Gly Pro Leu Val Cys Lys Val Asn Gly Thr Trp Leu Gln Ala Gly 
 225                230                235                240
Val Val Ser Trp Asp Glu Gly Cys Ala Gln Pro Asn Arg Pro Gly Ile 
                 245                250                255
Tyr Thr Arg Val Thr Tyr Tyr Leu Asp Trp Ile His His Tyr Val Pro 
             260                265                270
Lys Lys Pro 
         275



<210> 8827
<211> 1018
<212> DNA
<213> Rattus norvegicus
<308> U67915
<400> 8827

tccaggctg  accactggc  acaaaaaat  caggcccta  tattcctga  ggctcttct  60
ttgccttct  gagctggag  tgaggagat  atcggtggt  tggagtcta  accacactc  120
cgtccttac  tggcccatc  ggagatcac  actgagaga  gttacaagg  cacctgtgg  180
gggtttctt  tgacccgcc  atttgtgat  actgccgca  actgtaagg  aagagaaac  240
actgttacc  ttggagttc  tgatgtgag  aagacagaa  ccacacagc  gaagataaa  300
gtcgaaaaa  aaattgttc  cccaaatta  aacttctat  ccaatctcc  tgatatcat  360
ttactgaag  ttcaaaaga  agccaaggt  actcctgct  tggatgtaa  tcccctgcc  420
cagccctct  actttctca  gcctgggaa  atgtgccgg  cagctggct  ggggcaaac  480
ggagtgaca  aaccaacct  aaatacact  agggaggtg  aacagagaa  catggataa  540
gaggcctgt  aaaactatt  tcattataa  tataacttc  aggtctgcg  gggcagtcc  600
agaaagata  gatcagcat  taagggaga  tccggagga  cactagtgt  tgctggggt  660
gcccatggt  ttgtatctt  tggacgtgg  gatgcaaag  cccctgcag  cttcacccg  720
atctcccca  atgtgccct  gattaataa  gtcataaag  gcaaggatc  gaccagcct  780
agtctgcac  agtcagagt  tccaagcta  agaactctt  tgatatccc  tgggatcaa  840
aaagcctgt  cccagcctg  cacctgctt  tcccatacc  gttcccagc  tgcccccaa  900
ttgccccca  cccatcccc  gcctgtccc  agcctgtcc  taggatgat  tcaacaata  960
acaagtctg  ggtgatgga  tgttccctg  aaagcacct  aataaagac  taacctca  1018



<210> 8828
<211> 260
<212> PRT
<213> Rattus norvegicus
<308> P09650
<400> 8828

Met Gln Ala Leu Leu Phe Leu Met Ala Leu Leu Leu Pro Ser Gly Ala 
  1               5                  10                  15
Gly Ala Glu Glu Ile Ile Gly Gly Val Glu Ser Arg Pro His Ser Arg 
             20                  25                  30
Pro Tyr Met Ala His Leu Glu Ile Thr Thr Glu Arg Gly Tyr Lys Ala 
         35                  40                  45
Thr Cys Gly Gly Phe Leu Val Thr Arg Gln Phe Val Met Thr Ala Ala 
     50                  55                  60
His Cys Lys Gly Arg Glu Thr Thr Val Thr Leu Gly Val His Asp Val 
 65                  70                  75                  80
Ser Lys Thr Glu Ser Thr Gln Gln Lys Ile Lys Val Glu Lys Gln Ile 
                 85                  90                  95
Val His Pro Asn Tyr Asn Phe Tyr Ser Asn Leu His Asp Ile Met Leu 
             100                105                110
Leu Lys Leu Gln Lys Lys Ala Lys Val Thr Pro Ala Val Asp Val Ile 
         115                120                125
Pro Leu Pro Gln Pro Ser Asp Phe Leu Lys Pro Gly Lys Met Cys Arg 
     130                135                140
Ala Ala Gly Trp Gly Gln Thr Gly Val Thr Lys Pro Thr Ser Asn Thr 
 145                150                155                160
Leu Arg Glu Val Lys Gln Arg Ile Met Asp Lys Glu Ala Cys Lys Asn 
                 165                170                175
Tyr Phe His Tyr Asn Tyr Asn Phe Gln Val Cys Val Gly Ser Pro Arg 
             180                185                190
Lys Ile Arg Ser Ala Tyr Lys Gly Asp Ser Gly Gly Pro Leu Val Cys 
         195                200                205
Ala Gly Val Ala His Gly Ile Val Ser Tyr Gly Arg Gly Asp Ala Lys 
     210                215                220
Pro Pro Ala Val Phe Thr Arg Ile Ser Pro Tyr Val Pro Trp Ile Asn 
 225                230                235                240
Lys Val Ile Lys Gly Lys Asp Leu Thr Ser Leu Ser Leu His Glu Ser 
                 245                250                255
Glu Ser Pro Ser 
             260



<210> 8829
<211> 769
<212> DNA
<213> Homo sapiens
<308> M69136
<400> 8829

agcctctct  ggaagatgc  gcttcttcc  ctccccctg  tgctctttc  cttgtgctc  60
agagctgaa  ctggggaga  catcggggg  acagaatgc  agccacatt  ccgccccta  120
atggcctac  tggaaattg  aacttccaa  ggtccctca  aattttgtg  tggtttcct  180
ataagacgg  actttgtgc  gacggctgc  cattgtgca  gaaggtcta  aacagtcac  240
cttggagcc  ataacataa  agaggaaga  gacacatgg  agaagcttg  ggttataaa  300
caattccgt  atccaaaat  taacacttc  actcttcac  acgatatca  gttactaaa  360
ttgaaggag  aagccagcc  gaccctggc  gtggggaca  tccccttcc  atcacaatt  420
aactttgtc  cacctggga  aatgtgccg  gtggctggc  ggggaagaa  aggtgtgtt  480
aagccgggc  cagacactc  gcaagaggt  aagctgaga  tcatggatc  ccaggcctg  540
agccacttc  gagactttg  ccacaatct  cagctgtgt  tgggcaatc  caggaagac  600
aaatctgca  ttaagggag  ctctggggg  cctcttctg  gtgctgggg  ggcccaggg  660
atcgtatcc  atggacggt  ggatgcaaa  ccccctgct  tcttcaccc  aatctccca  720
taccggccc  ggatcaacc  gatcctgca  gcaaattaa  cctggatcc  769



<210> 8830
<211> 247
<212> PRT
<213> Homo sapiens
<308> P23946
<400> 8830

Met Leu Leu Leu Pro Leu Pro Leu Leu Leu Phe Leu Leu Cys Ser Arg 
  1               5                  10                  15
Ala Glu Ala Gly Glu Ile Ile Gly Gly Thr Glu Cys Lys Pro His Ser 
             20                  25                  30
Arg Pro Tyr Met Ala Tyr Leu Glu Ile Val Thr Ser Asn Gly Pro Ser 
         35                  40                  45
Lys Phe Cys Gly Gly Phe Leu Ile Arg Arg Asn Phe Val Leu Thr Ala 
     50                  55                  60
Ala His Cys Ala Gly Arg Ser Ile Thr Val Thr Leu Gly Ala His Asn 
 65                  70                  75                  80
Ile Thr Glu Glu Glu Asp Thr Trp Gln Lys Leu Glu Val Ile Lys Gln 
                 85                  90                  95
Phe Arg His Pro Lys Tyr Asn Thr Ser Thr Leu His His Asp Ile Met 
             100                105                110
Leu Leu Lys Leu Lys Glu Lys Ala Ser Leu Thr Leu Ala Val Gly Thr 
         115                120                125
Leu Pro Phe Pro Ser Gln Phe Asn Phe Val Pro Pro Gly Arg Met Cys 
     130                135                140
Arg Val Ala Gly Trp Gly Arg Thr Gly Val Leu Lys Pro Gly Ser Asp 
 145                150                155                160
Thr Leu Gln Glu Val Lys Leu Arg Leu Met Asp Pro Gln Ala Cys Ser 
                 165                170                175
His Phe Arg Asp Phe Asp His Asn Leu Gln Leu Cys Val Gly Asn Pro 
             180                185                190
Arg Lys Thr Lys Ser Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu 
         195                200                205
Cys Ala Gly Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Ser Asp Ala 
     210                215                220
Lys Pro Pro Ala Val Phe Thr Arg Ile Ser His Tyr Arg Pro Trp Ile 
 225                230                235                240
Asn Gln Ile Leu Gln Ala Asn 
                 245



<210> 8831
<211> 410
<212> DNA
<213> Rattus norvegicus
<308> U67994
<400> 8831

acgtgaaag  atttgaaca  tttctcgaa  acctggata  atctcggaa  ggggcactt  60
tcaagaaga  cgatttaca  aaagatttc  gaagaaaac  accccatca  accaatgtg  120
atgccttct  cattcaacc  tggagcatt  agtcaatgc  gtagaatcg  cagtgtgac  180
gaatcctta  agcagagct  tcttttctt  tctttcttt  ttctttttt  cggagctgg  240
gacgaaccc  gggccttga  cttgttagg  aagcgctct  ccactgagc  gaatcccca  300
cccctcaga  ctttctttt  agaaatcat  tatgtcaaa  agacctggt  tctgagacc  360
aagagggtg  caaaggccc  gaaagaaac  ataaatcaa  gaataaatgc  410



<210> 8832
<211> 29
<212> PRT
<213> Rattus norvegicus
<308> AAB39619
<400> 8832

Val Lys Val Phe Glu Gln Phe Leu Glu Asn Leu Asp Lys Ser Arg Lys 
  1               5                  10                  15
Gly Ala Leu Leu Lys Lys Ser Asp Leu Gln Lys Asp Phe 
             20                  25



<210> 8833
<211> 1399
<212> DNA
<213> Homo sapiens
<308> X74330
<400> 8833

cttaccgtg  cgagttccg  gctcaatgg  gacgtttga  cccaccgag  tgcccgagc  60
gcttaaact  tattaccgg  ggctctttc  ctactctca  tactatcgc  ggctcaact  120
cggtggagt  ataaagaat  actttcaac  ccgtgaatt  tcattcaca  tgaaagatg  180
tatttacat  cgctaccaa  ccttcaaca  ccagagtga  ctggaaaag  agatgcaga  240
aatgaatcc  tacaagatt  atataggcg  agtatattc  cacagaccc  atcaacaca  300
tacagtgaa  ctgggagct  tccaggctc  ggaaaaaga  ctggtattt  acattgaca  360
gacagacta  gacgatgtg  ggagatgtt  tagttctgc  gacatatgt  ctaagtgct  420
gaccctcat  acaatggcc  tacgcatca  tgacagagc  ttgaaggag  actttggat  480
taagcatcg  ctctgggta  attctggaa  gagaggtgt  cattgttgg  tctgtgatg  540
atcagttag  aaactgtct  ctgcagtac  ttctgggat  gttgagtat  tgagccttg  600
aaagggtgg  caagacgtt  aaaagaaag  tcacctaag  gaaaaaatt  accctttta  660
cagaaaatc  ataaacata  taaaaaaat  ctttgaaga  tatgccttg  ttaatcaag  720
tattctcga  aataaagaa  gctgggata  gattttagc  cttgttcct  aaacaattc  780
tgatgaact  caacaaagc  tccaaaagt  tcacaattc  cttcagcgt  gggagcact  840
gaagaaagt  gccagcaga  atcagaata  catcaaaaa  gacaaatat  gaccctggc  900
ggagtggga  attatgctc  agtactgtt  tccacggct  gatatcaat  tcagcaaag  960
aatcaatca  ctactgaag  gccctttta  tgttcatcc  aaaacaggt  gcatctctg  1020
gcctattga  ttgcagaaa  tggaccagt  tgatccatt  actgttccg  ccataagct  1080
catctgccg  gaattggat  ccatttcca  taatgaaga  gaaaaagag  agaatgaag  1140
tgaatctga  gtcaaacat  gaaccagag  ttataagaa  accagtcta  caccttatg  1200
gaaagtttt  gaacatttt  ttgaaaatc  ggataaatc  cgaaaagga  aacttctta  1260
gaagagtga  ttacaaaaa  atttctgaa  acagagctc  tcaaaccat  gtggatatc  1320
tctgccttc  accacagat  aaatacttc  agagccatt  aataaatat  gcagaacta  1380
aaagaaaaa  aaaaaaagg  1399



<210> 8834
<211> 420
<212> PRT
<213> Homo sapiens
<308> P49642
<400> 8834

Met Glu Thr Phe Asp Pro Thr Glu Leu Pro Glu Leu Leu Lys Leu Tyr 
  1               5                  10                  15
Tyr Arg Arg Leu Phe Pro Tyr Ser Gln Tyr Tyr Arg Trp Leu Asn Tyr 
             20                  25                  30
Gly Gly Val Ile Lys Asn Tyr Phe Gln His Arg Glu Phe Ser Phe Thr 
         35                  40                  45
Leu Lys Asp Asp Ile Tyr Ile Arg Tyr Gln Ser Phe Asn Asn Gln Ser 
     50                  55                  60
Asp Leu Glu Lys Glu Met Gln Lys Met Asn Pro Tyr Lys Ile Asp Ile 
 65                  70                  75                  80
Gly Ala Val Tyr Ser His Arg Pro Asn Gln His Asn Thr Val Lys Leu 
                 85                  90                  95
Gly Ala Phe Gln Ala Gln Glu Lys Glu Leu Val Phe Asp Ile Asp Met 
             100                105                110
Thr Asp Tyr Asp Asp Val Arg Arg Cys Cys Ser Ser Ala Asp Ile Cys 
         115                120                125
Pro Lys Cys Trp Thr Leu Met Thr Met Ala Ile Arg Ile Ile Asp Arg 
     130                135                140
Ala Leu Lys Glu Asp Phe Gly Phe Lys His Arg Leu Trp Val Tyr Ser 
 145                150                155                160
Gly Arg Arg Gly Val His Cys Trp Val Cys Asp Glu Ser Val Arg Lys 
                 165                170                175
Leu Ser Ser Ala Val Arg Ser Gly Ile Val Glu Tyr Leu Ser Leu Val 
             180                185                190
Lys Gly Gly Gln Asp Val Lys Lys Lys Val His Leu Ser Glu Lys Ile 
         195                200                205
His Pro Phe Ile Arg Lys Ser Ile Asn Ile Ile Lys Lys Tyr Phe Glu 
     210                215                220
Glu Tyr Ala Leu Val Asn Gln Asp Ile Leu Glu Asn Lys Glu Ser Trp 
 225                230                235                240
Asp Lys Ile Leu Ala Leu Val Pro Glu Thr Ile His Asp Glu Leu Gln 
                 245                250                255
Gln Ser Phe Gln Lys Ser His Asn Ser Leu Gln Arg Trp Glu His Leu 
             260                265                270
Lys Lys Val Ala Ser Arg Tyr Gln Asn Asn Ile Lys Asn Asp Lys Tyr 
         275                280                285
Gly Pro Trp Leu Glu Trp Glu Ile Met Leu Gln Tyr Cys Phe Pro Arg 
     290                295                300
Leu Asp Ile Asn Val Ser Lys Gly Ile Asn His Leu Leu Lys Ser Pro 
 305                310                315                320
Phe Ser Val His Pro Lys Thr Gly Arg Ile Ser Val Pro Ile Asp Leu 
                 325                330                335
Gln Lys Val Asp Gln Phe Asp Pro Phe Thr Val Pro Thr Ile Ser Phe 
             340                345                350
Ile Cys Arg Glu Leu Asp Ala Ile Ser Thr Asn Glu Glu Glu Lys Glu 
         355                360                365
Glu Asn Glu Ala Glu Ser Asp Val Lys His Arg Thr Arg Asp Tyr Lys 
     370                375                380
Lys Thr Ser Leu Ala Pro Tyr Val Lys Val Phe Glu His Phe Leu Glu 
 385                390                395                400
Asn Leu Asp Lys Ser Arg Lys Gly Glu Leu Leu Lys Lys Ser Asp Leu 
                 405                410                415
Gln Lys Asp Phe 
             420



<210> 8835
<211> 474
<212> DNA
<213> Rattus norvegicus
<308> U68272
<400> 8835

attatgtgc  gaaagggga  ggttggacc  cctggcctg  acatcggaa  gaaggaaga  60
cagctgatt  tccacatat  tcaccctaa  gtcaatgtg  gtcaggaaa  catgtttgg  120
gacggaaat  cctgttaca  attcgacta  actgtgttt  tgaaacatt  caggagtgg  180
gagatccta  atacagaac  tagcgtcct  aaagaagat  gtagcgaaa  tctgtgtga  240
ttaaacatc  cagtgtcca  gctgaattc  aattactgt  tttcagtag  tggaaagtc  300
tctttctgg  aagttaata  agaaacatc  aaagacgtc  gtatcccct  tctccatga  360
gacagagaa  aatcaattt  gatgctgct  gttgctcct  ttctcttcc  tacaatagt  420
gtcccggca  ttgtgtgtt  ttacattaa  aagaatcca  ttaagagaa  aagc  474



<210> 8836
<211> 158
<212> PRT
<213> Rattus norvegicus
<308> AAB17055
<400> 8836

Ile Met Cys Arg Lys Gly Lys Val Gly Pro Pro Gly Leu Asp Ile Gly 
  1               5                  10                  15
Arg Lys Glu Asp Gln Leu Ile Val His Ile Phe His Pro Lys Val Asn 
             20                  25                  30
Val Ser Gln Glu Thr Met Phe Gly Asp Gly Asn Thr Cys Tyr Thr Phe 
         35                  40                  45
Asp Tyr Thr Val Phe Val Lys His Tyr Arg Ser Gly Glu Ile Leu His 
     50                  55                  60
Thr Glu His Ser Val Leu Lys Glu Asp Cys Ser Glu Thr Leu Cys Glu 
 65                  70                  75                  80
Leu Asn Ile Ser Val Ser Thr Leu Asn Ser Asn Tyr Cys Val Ser Val 
                 85                  90                  95
Val Gly Lys Ser Ser Phe Trp Gln Val Asn Thr Glu Thr Ser Lys Asp 
             100                105                110
Val Cys Ile Pro Phe Leu His Asp Asp Arg Glu Glu Ser Ile Trp Met 
         115                120                125
Leu Leu Val Ala Pro Leu Leu Phe Leu Thr Ile Val Val Pro Ala Leu 
     130                135                140
Val Cys Cys Tyr Ile Lys Lys Asn Pro Phe Lys Arg Lys Ser 
 145                150                155



<210> 8837
<211> 1641
<212> DNA
<213> Homo sapiens
<308> AF056979
<400> 8837

ccagcgacc  tcggtagca  catggctct  ctctttctc  taccccttg  catgcaggg  60
gtgagcagg  ctgagatgg  caccgcgga  ctggggccg  cctcagtgc  tacaccaac  120
aatgttaca  ttgaatcct  taacatgaa  cctatcgta  attgggagt  ccagatcat  180
ccacaggtc  ctgttttta  cgtagaggg  aagaactat  gtgttaaga  ttcagaatg  240
attgatgcc  gcatcaata  ttctcatca  tattgtaat  tttctgatc  tgttggtga  300
ccatcaaat  ctctttggg  cagagttaa  gccagggtt  gacaaaaag  atctgccta  360
gcaaagtca  aagaatttg  tgtatgccg  gatggaaaa  ttggaccac  taaactgga  420
atcagaaag  aggagaagc  aatcatgat  gacatattt  acccttcag  ttttgtaaa  480
ggagacgag  aggaagtcg  ttatgatcc  gaaactacc  gttacatta  ggtgtacaa  540
gtgtatgtg  gaatgaacg  aagtgagat  cagtataaa  tactcacgc  gaaggaaga  600
gattgtgac  agattcagt  ccagttagc  attccagta  cctcactga  ttctcagta  660
tgtgtttca  cagaaggag  cttacatgt  tggggtgtt  caactgaaa  gtcaaaaga  720
gtttgtatt  ccattttca  tagcagtat  aaaggttct  tttggattc  agttgttgc  780
gctttacta  tctttctag  gcttagcct  gtattcatc  gtttttata  taagaaaat  840
aatccattg  aggaaaaaa  cataatatt  cccaagtcc  tgatctctg  ggtaagaag  900
gctacttta  agacaaaac  tgaatcaaa  tatgtatca  tcatcacgt  ataccagcc  960
ttttcctta  aaaaggagg  ggtctgtga  gagccgttg  ctccagcaa  agttccagg  1020
atgcatacc  aagacaatc  aggaaaagt  gaacataca  aagaacttt  tagtataac  1080
gaagtggtg  ctactgaag  aaatattcc  gacgtggtc  cgggcagcc  tctgactcc  1140
atagagaga  agagttctt  acctttaag  agtaaccag  ctgaacctg  cagcatcgc  1200
ttaaactcg  atcactcca  aaattgttc  gagagtgat  actccagaa  tggttttga  1260
actgattcc  gctgtctgg  atcacatag  tccttatct  actcagaat  tcccccaaa  1320
aataaaggt  aaataaaaa  agaaggaca  gagctcata  ccgtaataa  agcccccac  1380
tcctttggt  atgataaac  acatgtgct  gtggatcta  ttgtggatg  tagcggtaa  1440
gagtccttg  ttggttata  accaacaga  gattccaaa  aattttcat  agatcagct  1500
agttgcacc  actttgaag  ctgattttc  tggacagtt  tctgcttta  tttcatgaa  1560
agattatga  ctcagaaat  gtatcttag  tggtatcaa  caaatggag  gacttagtg  1620
acatgaaag  gtaaagagg  t  1641



<210> 8838
<211> 489
<212> PRT
<213> Homo sapiens
<308> P15260
<400> 8838

Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg 
  1               5                  10                  15
Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro 
             20                  25                  30
Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp 
         35                  40                  45
Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys 
     50                  55                  60
Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile 
 65                  70                  75                  80
Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn 
                 85                  90                  95
Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala 
             100                105                110
Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly 
         115                120                125
Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp 
     130                135                140
Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp 
 145                150                155                160
Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val 
                 165                170                175
Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu 
             180                185                190
Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser 
         195                200                205
Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp 
     210                215                220
Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn 
 225                230                235                240
Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu 
                 245                250                255
Leu Phe Leu Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys 
             260                265                270
Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile 
         275                280                285
Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr 
     290                295                300
Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val 
 305                310                315                320
Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr 
                 325                330                335
Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile 
             340                345                350
Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly 
         355                360                365
Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser 
     370                375                380
Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg 
 385                390                395                400
Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser 
                 405                410                415
Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro 
             420                425                430
Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val 
         435                440                445
Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val 
     450                455                460
Asp Leu Leu Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg 
 465                470                475                480
Pro Thr Glu Asp Ser Lys Glu Phe Ser 
                 485



<210> 8839
<211> 1548
<212> DNA
<213> Rattus norvegicus
<308> U68417
<400> 8839

cgggatcat  tctgcagct  tactaggac  ggtctggac  cggaagctt  tgcctattc  60
ctggcgtct  tgtgtgccc  gaagatgtg  gtcctccaa  ttcaaggcg  cagacctcc  120
ggttcaggt  accagagag  cacagaaga  gccagcccc  agccagcct  tgctgtttg  180
gaagacatt  acggaccac  tgctgatgg  ggagtggaa  agcaagaca  gctggggcc  240
tccaaggat  cagcccttc  agaacctca  actgcaccc  gcctgctcc  gcctgcact  300
ctcattgca  ctctttgaa  gcttgaaag  ttataaagg  agagacaag  aggtacgcc  360
cttccggcc  tggctcaac  tggacagga  gctacgttc  gcaaggcgc  tctgcctgc  420
agactttga  aagcaggaa  tgctggagt  catccgcca  ctcattgaa  tagacaaag  480
ctgggttcc  gatggcaat  gaacaagcc  ctatgtgcg  ccggtgctt  ttggaaatg  540
gccctccct  ggtgttgga  tggtcacac  agccctcct  ttcgtcatt  tgtgccctg  600
gggctccta  ttccccgga  actccatga  acctgtctc  ctcctggcg  acccctcat  660
cgtcagagc  tggattggt  gggtcggtg  ctgcaagtt  ggggggaat  acggcccca  720
tgtggctgt  caacaagaa  cccagaaga  aggctgcga  caggtcctc  ggctgtacg  780
gccggacca  cagctcacc  aggtgggaa  catgaacat  tttgtctac  ggactcatg  840
agacggaga  ctggagctg  caacccccc  actggatgg  atcatcctc  ccggagtgg  900
tcgacaaag  ctgctggat  tggccagga  ttggggtga  ttccgggtg  cagaacgca  960
ggtcactat  aaggaattg  agcgggcac  ggaggaggg  cgggtgcga  aagtcttcg  1020
ctcaggcac  gcttgtcag  tctgcccag  gcaccaaat  ctatatgaa  gcaagcaac  1080
ccacattcc  accatggaa  atgggccgg  actcatcct  cgcttccag  aggagttga  1140
ggctattca  tacggaacc  gtgcccacg  ttggatgct  cgtgtgtga  gttagggag  1200
ttgtgccct  cctggttgg  tccgctgac  tgcagcatc  agttcagcg  cctcgcctc  1260
cagagactc  agagaagtg  aatagggaa  gtcgttcca  actgctggc  ctctggcac  1320
ctcacgtgg  agttacact  caaagcctt  agggcggac  catgtaatt  ggaccccac  1380
tcagttcag  tcgtccgcg  cctggtgtt  aagagagaa  cttggcttc  tctcgatct  1440
cgttctcag  cggatcccc  gtgctcttc  tgtcttttt  ttttttttt  tccgtctct  1500
tctccttgc  gcaattttg  aataaaaat  ccaaagaac  agaaaaaa  1548



<210> 8840
<211> 393
<212> PRT
<213> Rattus norvegicus
<308> O35854
<400> 8840

Met Ser Ala Ala Ile Leu Gly Gln Val Trp Thr Arg Lys Leu Leu Pro 
  1               5                  10                  15
Ile Pro Trp Arg Leu Cys Val Pro Gly Arg Cys Val Ser Ser Asn Phe 
             20                  25                  30
Lys Ala Ala Asp Leu Gln Val Gln Val Thr Arg Glu Pro Gln Lys Lys 
         35                  40                  45
Pro Ala Pro Ser Gln Pro Leu Leu Phe Gly Lys Thr Phe Thr Asp His 
     50                  55                  60
Met Leu Met Val Glu Trp Asn Ser Lys Thr Gly Trp Gly Pro Pro Arg 
 65                  70                  75                  80
Ile Gln Pro Phe Gln Asn Leu Thr Leu His Pro Ala Cys Ser Gly Leu 
                 85                  90                  95
His Tyr Ser Leu Gln Leu Phe Glu Gly Leu Lys Ala Tyr Lys Gly Arg 
             100                105                110
Asp Lys Gln Val Arg Leu Phe Arg Pro Trp Leu Asn Met Asp Arg Met 
         115                120                125
Leu Arg Ser Ala Arg Arg Leu Cys Leu Pro Asp Phe Asp Lys Gln Glu 
     130                135                140
Leu Leu Glu Cys Ile Arg Gln Leu Ile Glu Val Asp Lys Asp Trp Val 
 145                150                155                160
Pro Asp Gly Asn Gly Thr Ser Leu Tyr Val Arg Pro Val Leu Ile Gly 
                 165                170                175
Asn Glu Pro Ser Leu Gly Val Gly Met Val Thr Gln Ala Leu Leu Phe 
             180                185                190
Val Ile Leu Cys Pro Val Gly Ser Tyr Phe Pro Gly Asp Ser Met Thr 
         195                200                205
Pro Val Ser Leu Leu Ala Asp Pro Ser Phe Val Arg Ala Trp Ile Gly 
     210                215                220
Gly Val Gly Asp Cys Lys Leu Gly Gly Asn Tyr Gly Pro Thr Val Ala 
 225                230                235                240
Val Gln Gln Glu Ala Gln Lys Lys Gly Cys Glu Gln Val Leu Trp Leu 
                 245                250                255
Tyr Gly Pro Asp His Gln Leu Thr Glu Val Gly Thr Met Asn Ile Phe 
             260                265                270
Val Tyr Trp Thr His Glu Asp Gly Glu Leu Glu Leu Ala Thr Pro Pro 
         275                280                285
Leu Asp Gly Ile Ile Leu Pro Gly Val Val Arg Gln Ser Leu Leu Asp 
     290                295                300
Leu Ala Arg Thr Trp Gly Glu Phe Arg Val Ala Glu Arg Lys Val Thr 
 305                310                315                320
Met Lys Glu Leu Lys Arg Ala Leu Glu Glu Gly Arg Val Arg Glu Val 
                 325                330                335
Phe Gly Ser Gly Thr Ala Cys Gln Val Cys Pro Val His Gln Ile Leu 
             340                345                350
Tyr Glu Gly Lys Gln Leu His Ile Pro Thr Met Glu Asn Gly Pro Glu 
         355                360                365
Leu Ile Leu Arg Phe Gln Lys Glu Leu Lys Ala Ile Gln Tyr Gly Thr 
     370                375                380
Ser Ala His Asp Trp Met Leu Arg Val 
 385                390



<210> 8841
<211> 1569
<212> DNA
<213> Homo sapiens
<308> BC001900
<400> 8841

cgccgcacg  atcatggcc  cagccgctc  ggggcagat  tgggcacga  agcttctct  60
tgtcccttg  cttctgtgt  gtcccagaa  atatgcctc  tccagtttc  aggctgcag  120
cctgcagct  gaaatgaca  agaagcctc  taagaagcc  ggccccggc  agcccctgg  180
gtttgggaa  acatttacc  accacatgc  gatggtgga  tggaatgac  agggctggg  240
ccagccccg  atccagccc  tccagaacc  cacgctgca  ccagcctcc  ccagcctcc  300
ctactccct  cagctgttt  agggcatga  ggcgttcaa  ggcaaagac  agcaggtgc  360
cctcttccg  ccctggctc  acatggacc  gatgctgcg  tcagccatg  gcctgtgcc  420
gccgagttt  gacaagctg  agttgctgg  gtgcatccg  cggctcatc  aagtggaca  480
ggactgggt  cccgatgcc  ccggcacca  cctctatgt  cggcctgtg  tcattggga  540
cgagccctc  ctgggtgtc  gccagccca  gcgcgcgct  ctgttcgtc  ttctctgcc  600
agtgggtgc  tacttccct  gaggctccg  gaccccggt  tccctcctg  ccgacccag  660
cttcatccg  gcctgggtg  gcggggtcg  caactacaa  ttaggtggg  attatgggc  720
caccgtgtt  gtgcaacag  aggcactca  gcggggctg  gaacaggtc  tctggctgt  780
tgggcccga  caccagctc  ccgaggtgg  aaccatgaa  atctttgtc  actggaccc  840
cgaagatgg  gtgctggag  tggtgacgc  cccgctgaa  ggtgttatc  tgcctggag  900
ggtcagaca  agtctactg  acatggctc  gacctgggg  gagttccgg  tggtggagc  960
cacgatcac  atgaagcag  tgctgcggg  cctggagga  ggccgcgtg  gggaagtct  1020
tggctcggg  accgcttgc  aggtctgcc  agtgcaccg  atcctgtac  aagacagga  1080
cctccacat  cccaccatg  aaaatgggc  tgagctgat  ctccgcttc  agaaggagc  1140
gaaggagat  cagtacgga  tcagagccc  cgagtggat  ttcccggtg  gaagctgca  1200
gctgtgctc  agatccacc  acccgtagc  tctcgtcac  ccagcactc  cctccctac  1260
aatgactca  ctgaagtgc  atacgaaat  aaaggccag  gggcggcgt  tgggtctct  1320
gcgccccca  gtggttgcg  cactcccaa  gccgtaagg  ccgacccag  catcttggc  1380
cccagcccc  cgtcgcggg  tcaggtccg  ccattactc  ttgtcgtgc  gtcaaggat  1440
caccttggc  ccgattccg  atctctccg  tctcaggcc  gacccctgg  gctgccgtt  1500
atttttttt  ctctgtctt  gctgcaatt  tgaaataaa  tgccaaaga  caaaaaaaa  1560
aaaaaaaaa  1569



<210> 8842
<211> 392
<212> PRT
<213> Homo sapiens
<308> O15382
<400> 8842

Met Ala Ala Ala Ala Leu Gly Gln Ile Trp Ala Arg Lys Leu Leu Ser 
  1               5                  10                  15
Val Pro Trp Leu Leu Cys Gly Pro Arg Arg Tyr Ala Ser Ser Ser Phe 
             20                  25                  30
Lys Ala Ala Asp Leu Gln Leu Glu Met Thr Gln Lys Pro His Lys Lys 
         35                  40                  45
Pro Gly Pro Gly Glu Pro Leu Val Phe Gly Lys Thr Phe Thr Asp His 
     50                  55                  60
Met Leu Met Val Glu Trp Asn Asp Lys Gly Trp Gly Gln Pro Arg Ile 
 65                  70                  75                  80
Gln Pro Phe Gln Asn Leu Thr Leu His Pro Ala Ser Ser Ser Leu His 
                 85                  90                  95
Tyr Ser Leu Gln Leu Phe Glu Gly Met Lys Ala Phe Lys Gly Lys Asp 
             100                105                110
Gln Gln Val Arg Leu Phe Arg Pro Trp Leu Asn Met Asp Arg Met Leu 
         115                120                125
Arg Ser Ala Met Arg Leu Cys Leu Pro Ser Phe Asp Lys Leu Glu Leu 
     130                135                140
Leu Glu Cys Ile Arg Arg Leu Ile Glu Val Asp Lys Asp Trp Val Pro 
 145                150                155                160
Asp Ala Ala Gly Thr Ser Leu Tyr Val Arg Pro Val Leu Ile Gly Asn 
                 165                170                175
Glu Pro Ser Leu Gly Val Ser Gln Pro Thr Arg Ala Leu Leu Phe Val 
             180                185                190
Ile Leu Cys Pro Val Gly Ala Tyr Phe Pro Gly Gly Ser Val Thr Pro 
         195                200                205
Val Ser Leu Leu Ala Asp Pro Ala Phe Ile Arg Ala Trp Val Gly Gly 
     210                215                220
Val Gly Asn Tyr Lys Leu Gly Gly Asn Tyr Gly Pro Thr Val Leu Val 
 225                230                235                240
Gln Gln Glu Ala Leu Lys Arg Gly Cys Glu Gln Val Leu Trp Leu Tyr 
                 245                250                255
Gly Pro Asp His Gln Leu Thr Glu Val Gly Thr Met Asn Ile Phe Val 
             260                265                270
Tyr Trp Thr His Glu Asp Gly Val Leu Glu Leu Val Thr Pro Pro Leu 
         275                280                285
Asn Gly Val Ile Leu Pro Gly Val Val Arg Gln Ser Leu Leu Asp Met 
     290                295                300
Ala Gln Thr Trp Gly Glu Phe Arg Val Val Glu Arg Thr Ile Thr Met 
 305                310                315                320
Lys Gln Leu Leu Arg Ala Leu Glu Glu Gly Arg Val Arg Glu Val Phe 
                 325                330                335
Gly Ser Gly Thr Ala Cys Gln Val Cys Pro Val His Arg Ile Leu Tyr 
             340                345                350
Lys Asp Arg Asn Leu His Ile Pro Thr Met Glu Asn Gly Pro Glu Leu 
         355                360                365
Ile Leu Arg Phe Gln Lys Glu Leu Lys Glu Ile Gln Tyr Gly Ile Arg 
     370                375                380
Ala His Glu Trp Met Phe Pro Val 
 385                390



<210> 8843
<211> 13894
<212> DNA
<213> Rattus norvegicus
<308> U68562
<400> 8843

ctttgggtc  cccaggaac  gtatgaagt  gcaattgag  aaatgcctt  attagattg  60
cccacagga  agctgatgg  acagaatct  aatgatgga  gtaggaagc  tctctgggt  120
atgccaccc  tgggtaggt  gcagtgggc  gtgtaagaa  gcaggctga  aagggtgca  180
gctgtaaca  cctaggtcc  tgctctttg  tttagcccc  gcccatggt  tcctgtaag  240
ttccttgaa  ttgagataa  ctttcttct  agagtagct  ttgctcagc  gttatcaca  300
gaatagaat  taaactaag  cagtaccta  gtgtaagtc  ccattcatc  atgtaataa  360
gccaaattc  tcctgaaag  tcatttacc  agaaatcca  tatttctca  aactcttta  420
ctctgtagc  tacttgaag  aaaagcacc  taaattacc  gactgtcca  tcatttata  480
tatttattt  gaaatgttt  taacagtac  gtgaaacta  atttcagag  caatggctg  540
cagtttagg  atcatccgt  tattataaa  gggaggcat  gaaattatt  acatgatga  600
atagttcag  atatcagtg  aatgggcag  ttcatgtga  accatttca  cagtgattt  660
agtcgacat  ctttccaag  atgtcgcca  ctctaaata  gaagtaatc  tgtgaataa  720
gagaccact  attaagata  taataacaa  tataaactg  ttttttttt  ggttctttt  780
ttttttttt  ggagctggg  accgaaccc  gggccttgc  cttcctagg  aagccctct  840
ccactgagc  aaatcccca  cccctaaac  gattttaaa  cattagctt  acttacctt  900
tcgtctagt  ctactttgg  gcctccgtg  tctgggaga  gaactttat  tccaacttt  960
acactgaca  gctgaatct  tccaccctg  tgaaaacag  cacttgtta  caaagatgt  1020
tgtcttgtt  actagatac  cattaaagt  tttgtttca  tatgtacac  aggagcctc  1080
tgcctcagg  ttgtgttaa  tataggcat  aatcacatt  aaactgtaa  ttttaagtc  1140
ctaaatttg  aaaagtgct  aaaccagta  ctggcaggt  cctaattag  ggttaagca  1200
tatagacct  acctacatt  aatgtagac  ttcataata  agcatcact  tagttacta  1260
atgacagag  tgccttcag  gggcagcta  ggttggcta  ctttttact  ttaaatatt  1320
acacaccgt  agaccaagg  aagggaagt  aagcaggta  ttgttacac  agacagcaa  1380
tggtcatgt  tgacttcga  caaatcgaa  aaattggca  tacttttct  catttaata  1440
acatttatt  acttaatgt  cttgttgtc  agacacaga  ttggtcaga  actgaagga  1500
aatgtccac  cccccatac  ctagcggtt  agttaagtg  agaacaccc  gagtagttc  1560
cctcctttc  caagtaggc  aactaaaac  cgaaatggt  taggatgat  tcagtgtct  1620
ggctaagcc  acagtcagg  tcctccacc  atcaccgca  ccttgcttt  ggggaacgg  1680
agtggggtg  tggggtcta  gtaaaaact  actggccat  aattctgga  ccccctcac  1740
cagcactgt  cctgtgcta  aattagttt  gtgccttat  aaatacctc  tccttcaat  1800
ctgaaaaga  ccctgggtt  atctacttg  atgactctt  ctgtctatt  aaaatttga  1860
gagtaggct  caaaataac  acagaggta  ttctttttt  ttttcagag  tggggaccg  1920
acccagggc  ttgcgcttg  taggcaagg  ctctaccac  gagctaaat  cccaaccca  1980
tacagaggt  tttcatttt  tgaggtttt  ttttacttt  agatatggt  tcgtcctgt  2040
cctcctgtt  gcctacaag  ctctataat  cacttgcct  ggcctccaa  gaacctggg  2100
tagaggcat  aggcactat  aaggcaggc  ctttttaat  tgtagtgtg  ggcactgct  2160
aattagctc  gtgggtaaa  agacttgct  tcaaagtat  ggaacccaa  ttgccatcc  2220
aacactata  taaaaagga  gtaaccccc  acatgctca  gccagaaac  agactagtt  2280
aacacgact  taccccaaa  gagtaaggt  gagatggcc  tgcaacaca  catacagac  2340
tgtgcacat  cagtcatac  actcaaata  cctctgcct  tttacagtc  ctgtcattc  2400
ttagaaata  aaaacattc  aaaattgtt  tcctgaatg  gaggttctt  gtgaattga  2460
atctaactt  aaattactt  caaaaaaac  ttgccattt  taattaact  tttaattaa  2520
aaaccaatt  ctcctcctt  ccacatcac  taaaattct  taccactct  ggagctccg  2580
gttacacct  tcctttccc  cctgatccc  cagccacga  cgttgcttg  aatactttt  2640
cttgagact  ttctggaag  ataatgcca  ctttggtca  agtttcagc  gcactcctt  2700
caaccaata  tctgtcaaa  agcggaaga  acttcctaa  agcttgtcc  gcctgtgga  2760
agaaatgtg  tcaaacaga  agtaattaa  ttcgaagtg  caggagacg  gttaattaa  2820
taccactgc  aaccttaac  ttaatagtc  aaagccttc  aaaatgaac  gaaaactta  2880
gtgtatctt  agaatatag  ccttcaatg  tcactccat  tagccagtt  attttcatt  2940
ccttgtctg  tgtgagtgt  tgggggccg  gggtcttca  tcgctcatc  gcaatcgca  3000
ccttggtct  tctccaagg  caaatattt  tcctttctc  gattttttt  tcaaactcg  3060
gtaacaggg  agtggtgtc  atttttaag  ccgatctta  tctttctcc  acataggac  3120
cattcacct  ggctgtgcc  gggcaggtg  gcttctgag  atgtacccg  gcgcccgcc  3180
cctgctcca  acgcctgcc  cacacgtgc  tgcagaaaa  ccgtggtgg  gaaagggtc  3240
gataggcct  gcttctgta  agcaacgga  gtcgctgga  actgagtga  ccctgtcct  3300
tcctgctag  cccaaagcg  acatggatc  gtcggcctg  cagccacga  cactcacca  3360
gacttacgc  gccgcagct  cggactctg  actcggact  ctgctgcaa  gagactccc  3420
tgggccggc  caggacacg  gaaaagaca  cgcagcgcg  aggcgcact  agcccctta  3480
cgtgagaga  ggcggccac  ccagcgcgc  cgccgattg  tggccagga  tccgcgcag  3540
cggccgatg  gggtagccg  aggcggaag  aaaggggag  actttctag  cttttccag  3600
tcggccgct  aggtgaaag  acaagcccc  cccggaaat  acgccactt  acctttcac  3660
cacgaaaag  gcggggcct  ccggaaggt  ctagaaccg  gcgcggccc  ggaaccagt  3720
tacggcggc  ggagagtgc  gaggccacg  ggctgaggc  gctcaggta  ggagggcgg  3780
gccgcgcgc  tcgcatgca  attgcaggg  cggggcgtg  gagaagtgg  gcgcgcgcg  3840
gcgcacgcg  ggcgcgggg  ggggccggg  agggagggg  ctcgggctc  ttgcggtgc  3900
cgcccagtg  tgggtccct  actcgccgc  gacggcctg  ctcgcctcg  gctcttccg  3960
cgccgcccc  caggtacgc  gcctcggcg  gcacggcgg  ccggtgctc  tgggcctgc  4020
tgcagcgcg  accgagcac  gagggctgg  gataagtct  tcagcgacg  gcaggctcg  4080
ttcacttgt  caggcccag  agggccata  tgctttcat  acgtgcggc  ggcaccacg  4140
gacctaggc  aagcgcggg  gcaagggcg  gctagggtg  gagcaactt  ggccctgtg  4200
ttccatctg  gcctggcga  tgtagggct  tatcggagg  tggtcgcgg  cctctagtc  4260
ctgtggccg  ggtgatccg  cgccttcac  ttgaccttg  tcggggctc  tggtcgaga  4320
gacacgtgg  gctcggcgc  tgcgctgag  tagggccct  ttctccggc  ttgcttgct  4380
ctgtgctac  gtagctccg  gtggatgct  gcgggcaca  tctccttag  gggttttgc  4440
ccgtcatta  tacttctgt  attctctag  cacttgcat  tagaacctg  ctgcttaca  4500
caacttttt  tttcagaca  ttttcggag  ggatctgct  ccaaggccg  tttggcagt  4560
aaagattaa  tcgagaggg  aggaggggg  ggccatggg  aggtggttt  gtgtgcttt  4620
tgctagtgc  gtaggtcag  catgggggc  gcctccatg  tcagttggt  aacagatta  4680
gtcctgaat  tgcagcgcc  ttagcagag  acagcagaa  tccaatcta  ccaccatat  4740
ttgaagcac  gttggacaa  tttgtagtg  tactttttt  ctttcccca  aaatgcttc  4800
actacccac  gtccttcgc  agatgagac  agtgtctcg  gcactggct  ctcatctca  4860
tcgggccta  gccaaagat  taaaatttg  tgcggatgc  cgagcctta  tgcttcaag  4920
tgtagacct  ttagccgat  ctgtagctg  tacaatggg  ccaaaggta  cagtatact  4980
atgtcgtgt  aaagaatag  gttctgtag  tgcaagaca  cattttgta  tcgagtttt  5040
tgagtatct  atttgcatg  ggtacaact  agtggtttg  ggggtgtta  ttaggtttg  5100
tagttggtc  ttctacgac  gtgtcctta  tgctgcttc  gtcgatttg  gagacttct  5160
tgcgttgtg  tgtaatagt  acagctcaa  gaagatttt  aaaccagag  catgactgt  5220
tgcatgctt  cattaaatt  tggatccca  cccagtagt  agagggtat  tagagggga  5280
agtacaact  cactctaat  actcaagtg  atagctgta  tgtgagcgt  cactgaacg  5340
tgaaatttc  aacataaaa  gcaaatgca  tagtgtaga  tcattactt  aaaggtgtc  5400
tatttttat  tgcatttta  tctgcctgc  tttatgtct  tgccagggt  ccaaggttc  5460
gggaactga  ttccccctt  ggaagagga  cctgtacta  taccaccaa  cctgtcttt  5520
cttaacttt  tgagctttg  tgtttgggt  ttttgtttg  tttattcaa  atgcatttc  5580
ctggtagcc  aggctgtcc  ggaactcaa  gagatcatc  acctgcttc  gcaacacat  5640
gtcagactc  ttttacttg  cctttggga  aaactttgt  gtctcccat  catctctac  5700
ttgtacata  ctcatgttt  tgcaattat  acattgcaa  gatttgtct  gttttgggt  5760
tttgagtct  actagttta  tctggcttc  aacgcccgt  gcaaggcta  cctcacatc  5820
ccagcgtag  aattcagta  tctactcac  cagtgtgtt  ttattatga  aaggtctct  5880
accatagct  gccaagtca  ccttgaact  gagcactgc  aagatcaga  gctgggatc  5940
cacatttaa  tggctgaat  gggagctat  gtactttga  gacatcatt  gatacagtg  6000
ggtcatttt  aattgatac  agactgaac  gcataatcc  agcattcag  aggctcagg  6060
aggtggatc  gaaagccat  gatctaaag  tataagaga  atcctgtct  gaaaaacaa  6120
acaacaaaa  gccctgcat  tttaagtac  gtttacata  ctcaagaca  aatagaagc  6180
tggttcaaa  ccaaaagtt  ccaataccg  cgttgccat  tttgaagtt  ttattgagt  6240
aaccagaag  gcccatatt  atcttactg  ctgatattt  gtgaatgaa  tttaaagca  6300
aacatgttt  tgataagca  ggcattagt  agtggttct  gcctctggt  ccagccttc  6360
ggaggcaga  gcaagtaga  ctttgtgct  tgtgagttt  aggacagcc  tggctgcac  6420
cagaagaac  ctgtctcag  aaacaaagc  agttcatag  caaactcaa  tacaaacga  6480
gtgaagaat  tcctgggat  tgtgttttc  tgttttata  gtagcatct  ttagttcca  6540
ggaattcct  ttgtgcctc  gtcaaagtt  gactccagg  cacatgagt  gtgttcatt  6600
tgtctatac  cctaagatg  ttgattaac  tggctttga  gttcgtgtt  caggattgt  6660
aacaatgac  acttcaagg  ttatcttta  gggttgata  ttttttttt  tgtcactat  6720
gggaagaac  gtgattatt  aacagagtt  gggaagtcc  aaagtaaca  aagatgggg  6780
cactgttgc  aagtcaatt  atttaaagg  taaatacaa  aatatcgga  ctaagcttg  6840
tcaggatgt  gccaataac  caaatgaag  ggctgggga  ggcaccacc  ctgccactg  6900
tctggcacc  tctattgcc  aggagggct  tgagaagat  agcaaaggg  ctaatccag  6960
ggaaatccg  agaggtaag  gtttgtcct  gatcctatg  tgtaaagaa  tctacatct  7020
catctttgt  ctttttgtt  tagagtttg  gtatgttct  ggtagagtt  cccttcctt  7080
cttatgtgg  tttccaaga  tgaactgag  ccttcaggc  tgtgggtcc  gtactttta  7140
tccctagac  tatcttcca  accttgttt  ttaacttat  taatggaag  gaaaataca  7200
ggctttcgg  atatccctg  ctgtcctgg  cacgcttgg  aactttgta  acctggcta  7260
ttagcttca  atagatctg  ctgcttctc  tttctgagt  ctggggtta  atgtgggca  7320
taccaccca  gcccaaggc  ctgtagtat  acttaacct  tgatccatc  cgtgagccc  7380
aagtagtga  aattctgaa  ctatctttt  ttgttttga  taggtctcc  ttttagcct  7440
ccctgacat  gttccctat  taatccatg  aggtctcaa  tttttagcc  ttctgtctc  7500
gtctcttgg  tcctcggat  acatgtgtg  gccaccatg  aacatctag  tcaagcttt  7560
caaaatgtt  gttttcagt  taaatgatt  attgaatgc  tactgttgt  tggtgcagt  7620
gggagagtg  tgacatgag  ggttgcatg  gatcgttag  aggaatctg  aattcttag  7680
ggggaccat  ataagcatt  tagtaacat  cattcttga  ctaggtgtg  tgttggctg  7740
tgatgctgt  attgctgaa  ttaagaaac  atctaaacc  gtgacaacc  ctgaagaaa  7800
tgctcaggt  aggatttta  ttcgtgttg  aaagaataa  tttgatctt  tggttccaa  7860
aacaggatt  gggtttgtc  ttgtagcca  gactatcct  gaattaaac  tatagatca  7920
gctgacctt  aactcaaat  cctctgctt  caaagtgct  gccccatca  tgttagatc  7980
tactctttt  agttttacg  tgctgtaaa  aaaatttgt  ttatttgtg  aaatattct  8040
aggtgatat  aatgtaccc  gtactatat  ggttcaaac  tagtccttg  agcatagtt  8100
acaagtgtt  tttatatgt  tgtgcctgg  tgttgtgtg  gttgcacca  atgcatgca  8160
gaacccata  gaagaatta  gagacagtt  ccagccact  tggtgtagg  gctggcccg  8220
acagtaagt  atcttaacc  ctgaggcat  tctccacct  tttagtttt  gtttattct  8280
aatgtgtca  ataatggag  aatgagggt  tagctccat  taaaactaa  aactggccc  8340
cttgctctc  tccttgctc  gtccccttg  tcctttccc  ttctctcca  tcccctccc  8400
actccccac  tgctcatgg  cggctctac  tttcttctg  ctttttctg  ctttactac  8460
catcctcat  ccctaaata  tcaattcta  tttaaaaaa  aaactatta  ctgtaaaat  8520
atcagttta  agtgtcaaa  gagaagaaa  ttgaaaata  taatcttac  atttgattt  8580
gaagtaaat  ggttatttc  ggttgctac  atttctgca  acggagaca  agacattgg  8640
aacatcatt  ctgatgcaa  gaagaaggt  ggaagaaag  gtgtcatca  agtgaaggc  8700
agcatggga  ttgatatgt  ttgataata  cttcaatgg  gtgtctgta  cctattttc  8760
aaataaaaa  ttgaatctc  tgtttgtgt  agtacaatt  attcctttg  cttaacatc  8820
gtattgagt  tatgctcac  attagtctg  atatttgcc  cctacaatg  gttcatcta  8880
cttaaataa  tagctctct  ctagctgta  atagaatgg  gcctctaat  ctggctgtc  8940
gggaactct  ggcttcaac  ttagagaga  ggcatccct  tgtcatctc  tctttctga  9000
gattaaaaa  ggcatgggt  cctgagctc  actttagtt  gtggcttga  tttttgtgg  9060
agtgcagtt  gaggacact  cagcatttc  atgttgagt  ccttatgcc  gtgtcatct  9120
ttgctaatt  ggtatgtaa  ttcaaatgt  ggcttatgt  tttgagaca  ggtctcatt  9180
tgtagtcat  tttttgaga  agggtctca  tgtatagat  gtccaaatt  ggcttgtgt  9240
tcttttaag  gattttttc  atctatgag  gtttgtttg  acatgtatg  gcaccttgg  9300
gtccagaag  aacagcaga  tcctaggaa  tgagttgag  accatcatg  aggtgcaca  9360
aacccaatt  tattcaaga  aagcaaatg  ggctggaaa  ctggatggc  cagtgatta  9420
gaacactgg  tgctcttcc  gagaccatg  gttcaatct  tagcaacca  atggtggct  9480
acagcaacc  aaaacggga  atagtgccc  ggtctggca  acaggtgta  atgctgata  9540
gagtatgta  aatatataa  ataagtata  ctttagaaa  aaaagagaa  agcaaatgt  9600
cttaaccct  gagccatct  taggtttag  tgaccaagt  ttgtttctt  agtttaaat  9660
ggatggaaa  accctgaat  atgagctag  aattattga  ggcatgaag  ttgatagag  9720
atatatttc  ccatatttt  ttaacacat  aaaaggtaa  agcccatcc  caagtgaaa  9780
tcgtcacaa  atgctctaa  ctgctaact  actgtcagc  gtgggtaat  ggtatggct  9840
atgcaataa  taaaaactg  gatgtttaa  cattaatgg  ttggtaaat  aagaagaac  9900
tgagttact  gtctcattg  ggaagtaaa  tgttttact  ctcattgta  ttataggtc  9960
aaaatgtga  ttccaagat  cctatgttt  gttgagtga  aagaaaatt  ctagtgttc  10020
gtccattgt  cctgctctt  aaattgcca  tgctcaccg  aagcccttg  tcataattg  10080
tgaagatgt  gatggagaa  ctcttagca  actggtttt  aacaggtaa  agataaatt  10140
gattgggtt  atatatttt  agatagaag  taatttctt  cttttgctt  tttgaaatt  10200
cacattttg  ttgtgtgtc  caaagctgt  gtatatatg  tgtagtgct  tatgcatta  10260
gagtctatc  ctagctggt  tcaaatgca  ataattctt  agcctgtgc  tcccacagc  10320
tcccagaga  aactataca  atgtctttt  tttttttgt  agatttatt  tatataatt  10380
cacaaggga  catcagatc  tattacaga  ggttgtgag  caccatgtg  ttgctggga  10440
ttgaactca  gacctctgg  agagcagtc  gttttctca  ccaactgag  catctctcc  10500
gctctacat  tgtcttttt  tcttttttt  tctttctct  cttttctct  ctttttttc  10560
gagctgggg  ttgaaccca  ggccttgca  ttgctaggc  agtgctcta  cactgagat  10620
aatccccaa  ccctcacac  tgtcttttt  acactggtg  gcttagcac  aatgcccaa  10680
tgtgtctgg  aatgtaaga  cagcatttc  ttaagaagg  aatcaggtt  aaacaaatt  10740
agatgagta  aggtcccca  ctcatcttt  ttaagacca  aagttgaag  aaaagagta  10800
ggtctgtac  gtcatgtag  cctagaact  accagggac  aaactagat  ctttttccc  10860
attccccct  tggtttaca  cttacgcag  taaatgtct  tacaggcta  aagttggtc  10920
tcaggttgt  gcagtcaaa  ctccagggt  tggggacaa  aggaagaac  agcttaaag  10980
tatggctat  gctactggt  gtgcggtaa  taaaccttg  catactgct  tgctcagtg  11040
tgtttatgc  tccagatcg  aaatacaat  tatacttca  aatagatgg  ctgtttctt  11100
ctattggat  tttggaaca  gggttggat  aaggtctca  ttctaactt  ctgagcctg  11160
cctgagaat  gacatgatt  aaagttctt  tcaaaattt  aaactaatt  gtgtaagtg  11220
ttttattta  actttgttc  gatatacca  tggaaaaat  gcatttctt  ctctggatt  11280
ttaagcttt  tgtatatgg  tgtttgtct  catgttttg  atgatgtat  cataccaga  11340
ggcatttta  ccagttcca  agcactaca  ttatagaca  ttgtaagct  ccatatgga  11400
gctgggatt  gaactcagg  cacctgaaa  agtagaata  ctctccagt  cttgtgact  11460
ctgagacat  tcactagcc  tgaaaagct  tttttcaca  aaatatttg  gactatagt  11520
ataaaccta  tataatgga  gccactaac  gcacattgt  tttataggt  tttggagaa  11580
agggtttga  tctaaatct  gaagatgtt  aagctcatg  tttaggaaa  gttggagag  11640
tcatcgtca  caaagatga  gccatgctt  tgaaaggaa  aggtgacaa  gctcacatt  11700
aaaaacgta  tcaagaaat  actgagcag  tagacatca  aactagtga  tatgagaag  11760
aaaagctga  cgagcgact  gctaaactc  cagatggag  agctgtgtt  aaggtaaga  11820
tgacttgca  gtaaacatt  taggctgag  ctggtgata  tggttcttt  gtatttacc  11880
atagtaact  agtgacctt  ccccaaatc  ttagttttt  ttgctcgtt  gttttggtt  11940
ttgcatgtg  tataaccaa  tttccatgg  gcacatgta  agggacaac  ttcagcagt  12000
ggtcatcta  ctttgcagt  atttttaga  gcaagcaag  cctttgacc  acttgggtc  12060
tatccttag  ccttctgag  catcaatag  catctatcc  ctactggta  tatgcatga  12120
accgaaacc  ttcttgtgc  gtgtcatgc  aacagtcta  cactgccca  tttcccagc  12180
tccttttct  tttttctct  tgtagccct  actgtctcg  aactcactc  gttaactct  12240
tagacagga  tttcagtcc  agaactcac  tagtagacc  agctagctt  gaactgaaa  12300
tcgctgcct  tgcctccca  gtgctggga  taaaggggt  tgcacttct  cttggctag  12360
atcctattc  cacagggca  tacagcttg  gttgtagga  gttttgata  ggggataca  12420
tataaccta  tactctaga  ttgcttcct  ctttgtttt  gttttgaac  ctgctgtca  12480
ccaggcagg  ctccgttgg  ataacccac  tgccttacc  tctcaagtg  tggggtcgt  12540
actatgaca  tatacccag  tcaggtctg  catccaggt  gcttcaagt  atcattgac  12600
gggaagggt  ggtactacc  ggaattttt  atttaatct  taggttgga  ggacaagtg  12660
tgttgaagt  aatgagaag  aagacagag  tacagatgc  ctcaatgct  caagagcag  12720
tgttgaaga  ggcattgtt  taggagggg  ctgtgctct  cttcggtgc  tcccagcct  12780
ggattcatt  aagcctgct  atgaagatc  gaagatagg  aaagattct  tcaaatgag  12840
ttgtggcca  agaggtaat  agcaatgca  cacacttta  aggggattg  ttcacctat  12900
gtaggattg  atgtctgat  gcttactaa  cttttatct  tataattat  ttatgtgtg  12960
gtgggagtg  attttgctc  catgtctcg  gtgctgtgt  tttgcagta  tctgagggg  13020
tggaaagat  gctcagtgg  taagagcac  gactgctct  ccagaggtc  tgagttcaa  13080
tcccagcaa  cacatggtg  ttcacagcc  tctgtgatg  gatctgatg  cctcttgtg  13140
gtgtctgaa  acagctgta  tgttgttat  tataataag  aaatttgaa  aaaaaagaa  13200
tgcagtatt  tgagggcca  atggggtca  cagatagct  ggaactgga  ttacattgg  13260
gctaaggat  aaaccaggt  ctctgaaaa  gaaaccatt  accattgag  catctttgg  13320
tccccaaaa  gggaaaaca  aagtaagtt  atgaaaatg  gtttgcttt  taggtatag  13380
aattattaa  agagcactt  aaattcctg  aatgacgat  gctaagaat  caggtgttg  13440
aggatcttt  atagttgaa  aaattctgc  gagttcctc  gaggttggc  atgatgcca  13500
gcttggaga  tttgtgaac  tggtggaaa  gggaatcat  gatccaaca  aggtaaata  13560
atcagcatt  ctaaacaat  aatgacttg  tctctggtg  atggttttc  ttaattttt  13620
tcttttttt  ggagctggg  accgaaccc  gggccttgc  tagcaagcg  tctaccact  13680
agctaaatc  ccaacccct  tctttaatt  ttaattgtt  tactaaatt  ttttctagg  13740
tgtaagaac  gctttactg  atgctgctg  ggtggcctc  ctgctaact  cagccgaag  13800
tgtagtgac  gaaattcct  aagaagaga  ggaccctgg  atgggtgca  tgggtggaa  13860
gggaggggg  atgggaggt  gcatgttct  actc  13894



<210> 8844
<211> 573
<212> PRT
<213> Rattus norvegicus
<308> U68562
<400> 8844

Met Leu Arg Leu Pro Thr Val Leu Arg Gln Met Arg Pro Val Ser Arg 
  1               5                  10                  15
Ala Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 
             20                  25                  30
Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 
         35                  40                  45
Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 
     50                  55                  60
Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 
 65                  70                  75                  80
Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 
                 85                  90                  95
Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 
             100                105                110
Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 
         115                120                125
Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 
     130                135                140
Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 
 145                150                155                160
Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 
                 165                170                175
Asn Gly Asp Lys Asp Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 
             180                185                190
Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 
         195                200                205
Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 
     210                215                220
Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 
 225                230                235                240
Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Val Gln Ser 
                 245                250                255
Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 
             260                265                270
Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 
         275                280                285
Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 
     290                295                300
Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 
 305                310                315                320
Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Asn Leu Asn Leu Glu Asp 
                 325                330                335
Val Gln Ala His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 
             340                345                350
Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala His Ile Glu 
         355                360                365
Lys Arg Ile Gln Glu Ile Thr Glu Gln Leu Asp Ile Thr Thr Ser Glu 
     370                375                380
Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 
 385                390                395                400
Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 
                 405                410                415
Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 
             420                425                430
Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 
         435                440                445
Pro Ala Leu Asp Ser Leu Lys Pro Ala Asn Glu Asp Gln Lys Ile Gly 
     450                455                460
Ile Glu Ile Ile Lys Arg Ala Leu Lys Ile Pro Ala Met Thr Ile Ala 
 465                470                475                480
Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Leu Gln 
                 485                490                495
Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Leu Gly Asp Phe Val Asn 
             500                505                510
Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 
         515                520                525
Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Ala 
     530                535                540
Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 
 545                550                555                560
Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 
                 565                570



<210> 8845
<211> 1854
<212> DNA
<213> Rattus norvegicus
<308> U70211
<400> 8845

caagatggc  ggggccggg  cccagctgt  agtcgccgc  gccgccgcg  cgcgctgcc  60
cgcagctag  ggcccggac  cccgccgga  aagatgagc  cccgccgcc  cctgcagcc  120
agccagacg  ggaccgccg  gcccggggc  ggctgcccc  ctagcgccc  gtcgcgccg  180
gccttcatc  ccggccccg  gcccgcccg  cagccacga  gagcgaaca  agtatctgc  240
aagcacggg  ctccgtgat  gtctacgat  acaccagta  gaaatgggt  ccaatcaag  300
ctggccagc  gggattcag  cggatcaac  tctaccaca  cactgccag  aacactttc  360
gggttgtag  ggtcaagct  caggatcag  aggttgtga  caattattc  attgtgaaa  420
ggctgaagt  caatcaggc  acacccacc  tccatcagt  gcgagacgc  cgtcaggtc  480
atggcttaa  ctttgcgag  aagggagaa  caaccacat  ctccaacgc  atgctcttt  540
ccctgaaca  catgaactc  caagaagga  gcccctcca  acagcgtca  gtgcagaat  600
gcccctctc  tgaggagat  gacatccag  gaagacaag  aatggagca  cagcaccgc  660
aggagtctc  ggagagaag  atctccgcc  cagggccca  tctcccccc  gggcatccg  720
catcggcag  cagcgccac  ttctcctgt  gtggacctc  acctccacc  ccacctcca  780
ttccacctc  acccacagg  tctactccc  cgcccccgc  cccgctgcc  gctggagga  840
cccagggga  caaccacga  gagagctct  catcaggac  ggctgctgc  ctggcagga  900
ccaagctaa  gagggtgca  cggccagag  atgcatctg  aggctccag  cctagcggg  960
cttcaaagt  cgatgccaa  cgggcaagc  gtgggggag  aggaggagg  ctcatggaa  1020
aaatgaaca  gctgctggc  aagaggaga  aggcagcct  ccagacaga  aagcccgct  1080
acagaaagg  agatgagaa  caaacggaa  atcctagca  ctccccatc  ccagggagc  1140
gagccacca  ccagccacc  aattcctca  aggctggcc  aaagccctg  gaacggagc  1200
actcggtgg  gaaacctgt  tcctcgttg  tgtccaggg  gaagcctgc  gggagtgtg  1260
atgacgtgg  cctggatgc  ttagatttg  accggatga  acaggagat  ctggaggag  1320
tggtccgag  gctccacaa  gtgaaggag  agatcatag  tgccatcag  caggaacta  1380
gtgggatca  caccacata  gatggcgcc  gccctggag  atcttgagg  gctgtgcta  1440
ccccagcga  catcgagcc  gcggaagct  ggatatact  aagtctcac  ctgtgatac  1500
atattaaaa  gaggaaaca  acttcaact  ctggatttt  tagtgtatc  gacacagaa  1560
accgggtct  ttctttttg  tattttata  ttgcttatt  aagtgtaca  tcctttggt  1620
tatagagaa  acccccaaa  cacctgctt  attagatgg  ttccaagtt  tctcctagg  1680
gacactgtt  gcacctcag  tggcaggga  cagctgggt  cagcgtgac  tttccgtgc  1740
acagagctg  caggatgca  cacagctcc  gcagccaca  tgtcccagt  tgtccacgc  1800
gtgcgtgtt  tgtccacag  ataaactgt  cactgtcca  aaaaaaaaa  aaaa  1854



<210> 8846
<211> 393
<212> PRT
<213> Rattus norvegicus
<308> AAC53322
<400> 8846

Met Ser Glu Gln Ser Ile Cys Gln Ala Arg Ala Ser Val Met Val Tyr 
  1               5                  10                  15
Asp Asp Thr Ser Lys Lys Trp Val Pro Ile Lys Pro Gly Gln Gln Gly 
             20                  25                  30
Phe Ser Arg Ile Asn Ile Tyr His Asn Thr Ala Ser Asn Thr Phe Arg 
         35                  40                  45
Val Val Gly Val Lys Leu Gln Asp Gln Gln Val Val Ile Asn Tyr Ser 
     50                  55                  60
Ile Val Lys Gly Leu Lys Tyr Asn Gln Ala Thr Pro Thr Phe His Gln 
 65                  70                  75                  80
Trp Arg Asp Ala Arg Gln Val Tyr Gly Leu Asn Phe Ala Ser Lys Gly 
                 85                  90                  95
Glu Ala Thr Thr Phe Ser Asn Ala Met Leu Phe Ala Leu Asn Ile Met 
             100                105                110
Asn Ser Gln Glu Gly Gly Pro Ser Thr Gln Arg Gln Val Gln Asn Gly 
         115                120                125
Pro Ser Pro Glu Glu Met Asp Ile Gln Arg Arg Gln Val Met Glu Gln 
     130                135                140
Gln His Arg Gln Glu Ser Leu Glu Arg Arg Ile Ser Ala Thr Gly Pro 
 145                150                155                160
Ile Leu Pro Pro Gly His Pro Ser Ser Ala Ala Ser Ala Thr Phe Ser 
                 165                170                175
Cys Ser Gly Pro Pro Pro Pro Pro Pro Pro Pro Val Pro Pro Pro Pro 
             180                185                190
Thr Gly Ser Thr Pro Pro Pro Pro Pro Pro Leu Pro Ala Gly Gly Ala 
         195                200                205
Gln Gly Thr Asn His Asp Glu Ser Ser Ala Ser Gly Leu Ala Ala Ala 
     210                215                220
Leu Ala Gly Ala Lys Leu Arg Arg Val Gln Arg Pro Glu Asp Ala Ser 
 225                230                235                240
Gly Gly Ser Ser Pro Ser Gly Thr Ser Lys Ser Asp Ala Asn Arg Ala 
                 245                250                255
Ser Ser Gly Gly Gly Gly Gly Gly Leu Met Glu Glu Met Asn Lys Leu 
             260                265                270
Leu Ala Lys Arg Arg Lys Ala Ala Ser Gln Thr Asp Lys Pro Ala Asp 
         275                280                285
Arg Lys Glu Asp Glu Asn Gln Thr Glu Asp Pro Ser Thr Ser Pro Ser 
     290                295                300
Pro Gly Ser Arg Ala Thr Ser Gln Pro Pro Asn Ser Ser Glu Ala Gly 
 305                310                315                320
Arg Lys Pro Trp Glu Arg Ser Asn Ser Val Glu Lys Pro Val Ser Ser 
                 325                330                335
Leu Leu Ser Arg Val Lys Pro Ala Gly Ser Val Asn Asp Val Gly Leu 
             340                345                350
Asp Ala Leu Asp Leu Asp Arg Met Lys Gln Glu Ile Leu Glu Glu Val 
         355                360                365
Val Arg Glu Leu His Lys Val Lys Glu Glu Ile Ile Asp Ala Ile Arg 
     370                375                380
Gln Glu Leu Ser Gly Ile Ser Thr Thr 
 385                390



<210> 8847
<211> 836
<212> DNA
<213> Homo sapiens
<308> BI767712
<400> 8847

cgatcttcc  tccggagcc  cgtcagcat  tatatcaat  aagtccact  cttctgaca  60
ggctccgga  ggaagatcg  gagtccgga  gatggacaa  gtaaggaag  tgccacggg  120
atatggcgg  ggcggcggc  agtccggac  aggcccgaa  cgcgcgaac  gcctgatca  180
cataggctg  tgggagtac  ggactcgcc  cctcagggt  ccctgtgct  ccacttttc  240
gccatggcc  caagtgaac  gagtatctg  caagcccgg  cttccgtga  ggtctacga  300
gacaccagt  agaaatggg  accaatcaa  cctggccag  agggattca  ccggatcaa  360
atctaccac  acactgcca  caacacctt  agagtcgtt  gagtcaagt  gcaggatca  420
caggttgtg  tcaattatt  aatcgtgaa  gggctgaag  acaatcagg  cacgccaac  480
ttccaccag  ggcgagatg  ccgccaggt  tacggctta  actttgcaa  taaagaaga  540
gcaaccacg  tctccaatg  aatgctgtt  gccctgaac  tcatgaatt  ccaagaagg  600
ggtgcgtgc  tcctctaat  acaaagcaa  cttgtattt  cttccacaa  tgaatggag  660
cagcctaac  tcatgtggc  cctccagcc  gcgtcaggt  cagaatggc  cctctcctg  720
tgagatgga  atccagaga  gacaagtga  ggagcagca  cagcagcag  gtcggaatc  780
ctagaaaga  gaacctcgg  acagggccc  tcctccacc  ggacatcct  catctc  836



<210> 8848
<211> 418
<212> PRT
<213> Homo sapiens
<308> NP_057421
<400> 8848

Met Ala Thr Ser Glu Gln Ser Ile Cys Gln Ala Arg Ala Ser Val Met 
  1               5                  10                  15
Val Tyr Asp Asp Thr Ser Lys Lys Trp Val Pro Ile Lys Pro Gly Gln 
             20                  25                  30
Gln Gly Phe Ser Arg Ile Asn Ile Tyr His Asn Thr Ala Ser Asn Thr 
         35                  40                  45
Phe Arg Val Val Gly Val Lys Leu Gln Asp Gln Gln Val Val Ile Asn 
     50                  55                  60
Tyr Ser Ile Val Lys Gly Leu Lys Tyr Asn Gln Ala Thr Pro Thr Phe 
 65                  70                  75                  80
His Gln Trp Arg Asp Ala Arg Gln Val Tyr Gly Leu Asn Phe Ala Ser 
                 85                  90                  95
Lys Glu Glu Ala Thr Thr Phe Ser Asn Ala Met Leu Phe Ala Leu Asn 
             100                105                110
Ile Met Asn Ser Gln Glu Gly Gly Pro Ser Ser Gln Arg Gln Val Gln 
         115                120                125
Asn Gly Pro Ser Pro Asp Glu Met Asp Ile Gln Arg Arg Gln Val Met 
     130                135                140
Glu Gln His Gln Gln Gln Arg Gln Glu Ser Leu Glu Arg Arg Thr Ser 
 145                150                155                160
Ala Thr Gly Pro Ile Leu Pro Pro Gly His Pro Ser Ser Ala Ala Ser 
                 165                170                175
Ala Pro Val Ser Cys Ser Gly Pro Pro Pro Pro Pro Pro Pro Pro Val 
             180                185                190
Pro Pro Pro Pro Thr Gly Ala Thr Pro Pro Pro Pro Pro Pro Leu Pro 
         195                200                205
Ala Gly Gly Ala Gln Gly Ser Ser His Asp Glu Ser Ser Met Ser Gly 
     210                215                220
Leu Ala Ala Ala Ile Ala Gly Ala Lys Leu Arg Arg Val Gln Arg Pro 
 225                230                235                240
Glu Asp Ala Ser Gly Gly Ser Ser Pro Ser Gly Thr Ser Lys Ser Asp 
                 245                250                255
Ala Asn Arg Ala Ser Ser Gly Gly Gly Gly Gly Gly Leu Met Glu Glu 
             260                265                270
Met Asn Lys Leu Leu Ala Lys Arg Arg Lys Ala Ala Ser Gln Ser Asp 
         275                280                285
Lys Pro Ala Glu Lys Lys Glu Asp Glu Ser Gln Met Glu Asp Pro Ser 
     290                295                300
Thr Ser Pro Ser Pro Gly Thr Arg Ala Ala Ser Gln Pro Pro Asn Ser 
 305                310                315                320
Ser Glu Ala Gly Arg Lys Pro Trp Glu Arg Ser Asn Ser Val Glu Lys 
                 325                330                335
Pro Val Ser Ser Ile Leu Ser Arg Thr Pro Ser Val Ala Lys Ser Pro 
             340                345                350
Glu Ala Lys Ser Pro Leu Gln Ser Gln Pro His Ser Arg Met Lys Pro 
         355                360                365
Ala Gly Ser Val Asn Asp Met Ala Leu Asp Ala Phe Asp Leu Asp Arg 
     370                375                380
Met Lys Gln Glu Ile Leu Glu Glu Val Val Arg Glu Leu His Lys Val 
 385                390                395                400
Lys Glu Glu Ile Ile Asp Ala Ile Arg Gln Glu Leu Ser Gly Ile Ser 
                 405                410                415
Thr Thr 
             420



<210> 8849
<211> 206
<212> DNA
<213> Rattus norvegicus
<308> U70270
<400> 8849

cccctccgc  ccagactcc  agctcctgc  cccagccta  tgacctagc  ctccccagc  60
tgctctgtg  tattgtcac  tatgctgac  tcctctctt  tgcagattc  tacacacac  120
acaacgtgt  agggaggaa  aagaaagat  ttttgggga  tgactttct  tttagatac  180
gtacagtaa  ttggtcaga  taaaag  206



<210> 8850
<211> 1600
<212> DNA
<213> Rattus norvegicus
<308> U70779
<400> 8850

gggaggggg  cggggacca  ggcgacgac  cgggggacg  cggggcccc  cggggagag  60
ggagggcgg  cccgggcgg  aaggagggg  tctccccgg  cgtgggagg  gggcggcgg  120
gcctcgtcc  gccgcggcg  gcgcccagc  ccgcctaca  accccagcc  gccactcca  180
ctctacacc  gtctcccag  cagaggtgc  gcatgaggg  ccgcagggg  gatcgcatg  240
ccatcaaca  ccaggagca  atggccatc  acgtgtgcc  tggacccat  aggcccatc  300
gccagatct  cgactactt  cctcgcagg  ggccaggac  agagggtgg  ggcggcggc  360
ggggcttcg  ggaagcccc  gctcatctg  cccctctgg  tctggcccc  cctgcggct  420
tccttgggg  cactacacc  gacgatgga  ctgaggtag  cagctacga  tcggatgat  480
ccactgccc  gggcacgct  gaatttgac  ttctctatg  tcaggcttc  tgcatgctg  540
actgtagaa  cctcagggc  aagggcctc  agcccatgg  tttcaacgg  ctggctgac  600
cctatgtaa  gctgcacct  ctgccagga  cctgcaagg  caataagct  aaaaccaag  660
cacagagga  cacactgaa  ccagtgtgg  acgaggagc  gacgtacag  ggaatcaca  720
atgacgaca  cacccacaa  gtgctcagg  tctcggtct  tgatgagga  aagctgagt  780
acaatgaat  tattgggga  atccgagtg  ccctccgcc  cctcaagcc  tcacagaag  840
agcatttta  catctgcct  gagcgtcag  tcccgcttc  ttcgccctc  tcaatgtct  900
cggcgctga  gggcatatc  tgttacctg  aggagctag  gcaggcaga  cagggacct  960
ggctgttgg  agagcgcgg  cgcatcctg  tgagcctca  ctacagctc  cggcggcat  1020
ggctgctgg  gggcattgt  cgctgtgct  acctggctg  aatggatgt  aacggctac  1080
ctgaccctt  tgtgaagac  tacttgaga  cagacgtgg  taagaaatc  aagcataag  1140
cgtgtgtaa  gaagaagac  ctgaacccg  aatttaatg  ggaattctt  tatgagatg  1200
aactctcca  tctggctac  aagaccctg  aagtcacag  ctgggacta  gacattggc  1260
aatccaatg  cttcatagg  ggtgtgtct  tggggccag  agcccgggg  gaggcccag  1320
aacactgga  agactgtct  catcagccg  acacagcag  ggagcgctg  cataccctg  1380
ccagcgagc  gcccccagc  gcaggggcg  tgccgttgg  ctgaacaga  tgcagctgc  1440
cagcacagg  cctctgcgg  cgggtccag  acccaacct  cgcacgagt  tgttgcacg  1500
ttacatggg  gggacgccc  gccccacac  acctgtctt  tttttgtga  tttctgtga  1560
cgtgggtct  tcttcttgt  agggattgt  gagagctata  1600



<210> 8851
<211> 403
<212> PRT
<213> Rattus norvegicus
<308> AAB47748
<400> 8851

Met Arg Gly Arg Arg Gly Asp Arg Met Thr Ile Asn Ile Gln Glu His 
  1               5                  10                  15
Met Ala Ile Asn Val Cys Pro Gly Pro Ile Arg Pro Ile Arg Gln Ile 
             20                  25                  30
Ser Asp Tyr Phe Pro Arg Arg Gly Pro Gly Pro Glu Gly Gly Gly Gly 
         35                  40                  45
Gly Arg Gly Phe Gly Glu Ala Pro Ala His Leu Ala Pro Leu Ala Leu 
     50                  55                  60
Ala Pro Pro Ala Ala Leu Leu Gly Ala Thr Thr Pro Asp Asp Gly Ala 
 65                  70                  75                  80
Glu Val Asp Ser Tyr Asp Ser Asp Asp Thr Thr Ala Leu Gly Thr Leu 
                 85                  90                  95
Glu Phe Asp Leu Leu Tyr Asp Gln Ala Ser Cys Met Leu His Cys Arg 
             100                105                110
Ile Leu Arg Ala Lys Gly Leu Lys Pro Met Asp Phe Asn Gly Leu Ala 
         115                120                125
Asp Pro Tyr Val Lys Leu His Leu Leu Pro Gly Ala Cys Lys Ala Asn 
     130                135                140
Lys Leu Lys Thr Lys Thr Gln Arg Asn Thr Leu Asn Pro Val Trp Asn 
 145                150                155                160
Glu Glu Leu Thr Tyr Ser Gly Ile Thr Asp Asp Asp Ile Thr His Lys 
                 165                170                175
Val Leu Arg Ile Ser Val Cys Asp Glu Asp Lys Leu Ser His Asn Glu 
             180                185                190
Phe Ile Gly Glu Ile Arg Val Pro Leu Arg Arg Leu Lys Pro Ser Gln 
         195                200                205
Lys Lys His Phe Asn Ile Cys Leu Glu Arg Gln Val Pro Leu Pro Ser 
     210                215                220
Pro Ser Ser Met Ser Ala Ala Leu Arg Gly Ile Ser Cys Tyr Leu Lys 
 225                230                235                240
Glu Leu Glu Gln Ala Glu Gln Gly Pro Gly Leu Leu Glu Glu Arg Gly 
                 245                250                255
Arg Ile Leu Leu Ser Leu Ser Tyr Ser Ser Arg Arg His Gly Leu Leu 
             260                265                270
Val Gly Ile Val Arg Cys Ala His Leu Ala Ala Met Asp Val Asn Gly 
         275                280                285
Tyr Ser Asp Pro Tyr Val Lys Thr Tyr Leu Arg Pro Asp Val Asp Lys 
     290                295                300
Lys Ser Lys His Lys Thr Cys Val Lys Lys Lys Thr Leu Asn Pro Glu 
 305                310                315                320
Phe Asn Glu Glu Phe Phe Tyr Glu Met Glu Leu Ser Thr Leu Ala Thr 
                 325                330                335
Lys Thr Leu Glu Val Thr Val Trp Asp Tyr Asp Ile Gly Lys Ser Asn 
             340                345                350
Asp Phe Ile Gly Gly Val Ser Leu Gly Pro Gly Ala Arg Gly Glu Ala 
         355                360                365
Gln Lys His Trp Arg Asp Cys Leu His Gln Pro Asp Thr Ala Val Glu 
     370                375                380
Arg Trp His Thr Leu Thr Ser Glu Leu Pro Pro Ala Ala Gly Ala Leu 
 385                390                395                400
Pro Leu Ala 
                 405



<210> 8852
<211> 1621
<212> DNA
<213> Homo sapiens
<308> NM_003586
<400> 8852

tcctgacgg  gctggagct  aggggcagt  cggatgccc  aggaaggct  ctaggaaga  60
gggacccac  gtgacttcc  aaggaagcg  ggttcccag  caggggtgc  gcatgaggg  120
ccgcagggg  gatcgcatg  ccatcaaca  ccaggagca  atggccatc  acgtgtgcc  180
cgggcccat  cggcccatc  gccagatct  tgactactt  ccccgggga  caggacctg  240
agggggcgg  gggagcggc  gggaggccc  cgcccatct  gtccccctg  ctctggccc  300
ccctgcagc  ctccttggg  ccaccacgc  tgaggatgg  gcggaggtg  acagctatg  360
ctcggatga  gccaccgcc  taggcaagc  ggagtttga  cttctctac  accgggcct  420
ctgcactct  cacgtatgc  tcctcaggg  caagggcct  aagcccatg  atttcaatg  480
cctcgccga  ccctacgtc  agctgcact  gctgcctgg  gcctgtaag  ccaataagc  540
aaaaacgaa  actcagagg  acacactga  tcccgtgtg  aatgaggac  tgacttaca  600
cgggatcac  gatgacgac  tcacgcaca  ggtgctcag  atcgccgtc  gtgatgagg  660
caagctgag  cacaatgag  ttattgggg  gatccgcgt  cccctccgc  gcctcaagc  720
ttcgcagaa  aagcatttt  acatctgcc  cgagcgcca  gtcccgctg  cgtccccct  780
ttccatgtc  gcggcgctg  ggggcatct  ctgttatct  aaggacttg  agcaggcgg  840
gcaggggca  gggctgctg  aggagcgtg  ccgcatcct  ctgagtctc  gctacagct  900
gcggcgccg  ggactgctg  taggcatct  gcgctgcgc  catctggct  ccatggacg  960
caacggtta  tcggacccc  acgtcaaga  gtacctgag  cccgatgtg  acaagaaat  1020
caagcataa  acgtgtgtg  agaagaaga  tctcaaccc  gaatttaac  aggagtttt  1080
ctacgagat  gagctctcc  ctctggcca  caagaccct  gaagtcacc  tctgggact  1140
tgacattgg  aaatccaat  acttcattg  tggcgtgtc  ctggggcca  gtgcccgag  1200
cgaggctcg  aagcactgg  gtgactgcc  gcagcagcg  gacgcagcc  tggagcgct  1260
gcacaccct  accagtgag  tgccccctg  ggccggggc  ctgtcctca  cctgagtgg  1320
cagcagtgt  ccggcacag  cccatcgag  cgggtccag  acccaacct  cgcacgagt  1380
tgttgcacg  ttacacagg  gggctgccc  accctgcac  acctatttt  tgagtctcg  1440
gacccgggt  tgtctgctc  tgaggggct  cggagttct  tattcacat  tgcaaacct  1500
ctgcctgac  cgctagtcc  tgcaaatat  caaaccccc  tactactgc  cacccgggc  1560
gtgctcaga  ccgcccagg  cccgcgctc  tcactcctg  ctctccacg  tgccccgtc  1620
c  1621



<210> 8853
<211> 400
<212> PRT
<213> Homo sapiens
<308> NP_003577
<400> 8853

Met Arg Gly Arg Arg Gly Asp Arg Met Thr Ile Asn Ile Gln Glu His 
  1               5                  10                  15
Met Ala Ile Asn Val Cys Pro Gly Pro Ile Arg Pro Ile Arg Gln Ile 
             20                  25                  30
Ser Asp Tyr Phe Pro Arg Gly Pro Gly Pro Glu Gly Gly Gly Gly Ser 
         35                  40                  45
Gly Gly Glu Ala Pro Ala His Leu Val Pro Leu Ala Leu Ala Pro Pro 
     50                  55                  60
Ala Ala Leu Leu Gly Ala Thr Thr Pro Glu Asp Gly Ala Glu Val Asp 
 65                  70                  75                  80
Ser Tyr Asp Ser Asp Asp Ala Thr Ala Leu Gly Lys Leu Glu Phe Asp 
                 85                  90                  95
Leu Leu Tyr Asp Arg Ala Ser Cys Thr Leu His Val Cys Ile Leu Arg 
             100                105                110
Ala Lys Gly Leu Lys Pro Met Asp Phe Asn Gly Leu Ala Asp Pro Tyr 
         115                120                125
Val Lys Leu His Leu Leu Pro Gly Ala Cys Lys Ala Asn Lys Leu Lys 
     130                135                140
Thr Lys Thr Gln Arg Asn Thr Leu Asn Pro Val Trp Asn Glu Asp Leu 
 145                150                155                160
Thr Tyr Ser Gly Ile Thr Asp Asp Asp Ile Thr His Lys Val Leu Arg 
                 165                170                175
Ile Ala Val Cys Asp Glu Asp Lys Leu Ser His Asn Glu Phe Ile Gly 
             180                185                190
Glu Ile Arg Val Pro Leu Arg Arg Leu Lys Pro Ser Gln Lys Lys His 
         195                200                205
Phe Asn Ile Cys Leu Glu Arg Gln Val Pro Leu Ala Ser Pro Ser Ser 
     210                215                220
Met Ser Ala Ala Leu Arg Gly Ile Ser Cys Tyr Leu Lys Asp Leu Glu 
 225                230                235                240
Gln Ala Glu Gln Gly Gln Gly Leu Leu Glu Glu Arg Gly Arg Ile Leu 
                 245                250                255
Leu Ser Leu Ser Tyr Ser Ser Arg Arg Arg Gly Leu Leu Val Gly Ile 
             260                265                270
Leu Arg Cys Ala His Leu Ala Ala Met Asp Val Asn Gly Tyr Ser Asp 
         275                280                285
Pro Tyr Val Lys Thr Tyr Leu Arg Pro Asp Val Asp Lys Lys Ser Lys 
     290                295                300
His Lys Thr Cys Val Lys Lys Lys Thr Leu Asn Pro Glu Phe Asn Glu 
 305                310                315                320
Glu Phe Phe Tyr Glu Ile Glu Leu Ser Thr Leu Ala Thr Lys Thr Leu 
                 325                330                335
Glu Val Thr Val Trp Asp Tyr Asp Ile Gly Lys Ser Asn Asp Phe Ile 
             340                345                350
Gly Gly Val Ser Leu Gly Pro Gly Ala Arg Gly Glu Ala Arg Lys His 
         355                360                365
Trp Ser Asp Cys Leu Gln Gln Arg Asp Ala Ala Leu Glu Arg Trp His 
     370                375                380
Thr Leu Thr Ser Glu Leu Pro Pro Ala Ala Gly Ala Leu Ser Ser Ala 
 385                390                395                400



<210> 8854
<211> 1742
<212> DNA
<213> Rattus norvegicus
<308> U72350
<400> 8854

cacagagca  acccagtga  tgagcaggt  ttttggaca  tggactggt  gagcccatc  60
ctattataa  aatgtctca  agcaaccgg  agctggtgg  tgactttct  tcctacaag  120
tctcccaga  aggatacag  tggagtcag  ttagcgatg  cgaagagaa  aggactgaa  180
ccccagaag  aactgaacc  gaaagggag  cccccagtg  catcaatgg  aacccatcc  240
ggcacctgg  ggatagccc  gcggtgaat  gagccactg  ccacagcag  agtttggat  300
cgcgggagg  aatccccat  gcagcagtg  agcaagcgc  gagagaggc  ggcgatgag  360
ttgaactgc  gtaccggag  gcattcagt  atctaacat  ccagcttca  ataacccca  420
ggacagcat  tcagagctt  gaacaggta  tgaatgaac  ctttcggga  ggggtaaac  480
ggggtcgca  tgtggcctt  ttctccttt  gcggggcac  gtgcgtgga  agcgtagac  540
aggagatgc  ggtattggt  agtcggatt  caagttgga  ggccaccta  ctgaatgac  600
acctagagc  ttggatcca  gagaacggc  gctgggaca  ttttgtgga  ctctacggg  660
acaatgcag  agccgagag  cggaaaggc  aggagcgtt  caaccgctg  ttcctgacg  720
gcatgactg  ggctggtgt  gttctgctg  gctcactct  cagtcggaa  tgaccagac  780
ctgaccgtc  actcacctc  cacctccca  cttgccccc  ccacaactc  ctcttcagc  840
accattgct  ccaggagaa  cactacatg  aactcacgc  ccttcccct  ttatagggt  900
gggcctaga  ggagtcccc  gcagttagc  ttctagaat  taccacgct  ctgtgaaag  960
caccttccc  ccacatctc  gttcccttg  cctcaaaac  cacaaggtt  ttcctcaga  1020
cagctcctt  gaggctggc  ggagtggga  ggggtgtgc  agagggaga  gagcctgcc  1080
tgttggtgg  accctgatt  cccctgagc  tctcgggaa  gcttttctg  cagggagct  1140
gagagctct  taaacctct  cccccagag  ctagattgc  ttggttttg  tgtgtgtgg  1200
ctcagaatt  atccatttc  cattctgct  tgtccctgg  gcggctcct  cttcccatc  1260
ccacccccc  ccccccaga  ccattgagt  aggtgcttt  agccctttt  actaactaa  1320
aatgcaggc  gcttgggat  acgaggcaa  gacctcctc  ccacctgtg  cctggccaa  1380
cccccactc  tggtctgaa  gttctcctg  ggcctctgg  tagagtcca  ccccaccca  1440
gaggaggga  ggagctgcg  aaagtccac  ctgcgagag  ctgagcggc  cttgcggct  1500
agcaccacc  cagatcctt  tccacccct  ccctggctc  atggtgacc  tgactgagg  1560
accaactgg  cccacgcta  gtgccccag  gctgttaat  acttcagct  cctcacttc  1620
tgcaagatc  gcctgtggc  tctttgcct  gggtgctgg  cacagggtc  agggactct  1680
gccttagcc  agaagtgag  ggaagctta  agcgcagct  tgggagccc  gggggcttc  1740
ct  1742



<210> 8855
<211> 233
<212> PRT
<213> Rattus norvegicus
<308> P53563
<400> 8855

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
  1               5                  10                  15
Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
             20                  25                  30
Asn Arg Thr Glu Ala Pro Glu Glu Thr Glu Pro Glu Arg Glu Thr Pro 
         35                  40                  45
Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
     50                  55                  60
Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
 65                  70                  75                  80
Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                 85                  90                  95
Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
             100                105                110
His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
         115                120                125
Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
     130                135                140
Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
 145                150                155                160
Val Leu Val Ser Arg Ile Ala Ser Trp Met Ala Thr Tyr Leu Asn Asp 
                 165                170                175
His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
             180                185                190
Asp Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
         195                200                205
Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
     210                215                220
Leu Leu Gly Ser Leu Phe Ser Arg Lys 
 225                230



<210> 8856
<211> 2472
<212> DNA
<213> Rattus norvegicus
<308> U72497
<400> 8856

ggtttgtgc  agccgagtt  tctcgggtg  cggtcggct  caggagatc  tggtgctga  60
cgaagtgtg  accacgctg  ctggggtct  cggggtttg  ctagcctgc  gcttgttgt  120
ggcggcggt  gtcctgcga  ggaccgggc  ccagaaggc  cggggcgcg  cgaccaggg  180
gcggcagaa  cagcgagcc  gcctggaga  catggacaa  gcggtgcag  gcttccggc  240
gcagaatcc  gacctggac  cggaggcct  gctgaccct  cccctactc  aactggtac  300
gaagttaca  agtggagag  tgtccccag  ggctgtgtt  tttacttac  tgggaaagg  360
ctgggaagt  aacaaaggg  ccaactgcg  gacctccta  ctgaccgac  gtgagactc  420
gctgtccca  gccccacgg  agggcctgc  ctatggtgt  cctgtgagc  tcaaggaat  480
cttcagcta  aagggccac  actccacac  gggcttgag  ctgaatgag  gcatgccat  540
ggaatctga  tgtgtggtg  tgcaagtgt  gaagctgca  ggagctgtg  cctttgtgc  600
taccaatgt  ccccagtcc  tgttaagct  tgactgcag  aaccctctc  ttggccaga  660
catgaaccc  tggaagtcc  ccaagagcc  aggaggttc  tcagggggt  agggggctc  720
cattggatc  ggaggttcc  ctctgggtt  aggcactga  attggcggc  gcatccggt  780
cccttctgc  ttctgcggc  tctgtggcc  caagcctac  ggcaaccgc  tcagcaaga  840
tggcctgaa  ggctgtgtc  atggacaga  ggcagtgca  ctttctctt  gccccatgg  900
ccgggatgt  gagagcctg  cgctatgcc  gaaagctct  ctgtgtgag  acttgttca  960
cttggaccc  accgtgcct  ccttgccct  cagagagga  gtctataga  gttctagac  1020
cctgcgtgt  gggtactat  agactgaca  ctataccat  cccagccca  ctatgagga  1080
ggctctgat  gagaccaag  agagacttg  ggctgctgg  cacacgctg  ttcccttct  1140
acccaacaa  ataccctac  ccctggagg  cctgtctgc  ggcggcctg  tcagtgacg  1200
tggccgcag  tttctccaa  acttcaaag  tgactttgt  gatccctgc  tgggagacc  1260
gatcttaat  ctgaggctg  ccagctggt  taaaagact  ctgagcctc  tgctgaagc  1320
tctgtttcc  cggctggca  cctttctca  cagtatgcg  cctcggtca  ctgaaaagc  1380
gtggaaact  cagcatgag  ttgagatgt  tcgccagtc  gtgattgcc  agtggaaag  1440
gatgaactt  gatgtgctg  tgaccccca  gttgggccc  gctctggat  tgaacacac  1500
gggcagagc  acaggggct  tcagctaca  cgttctcta  aactgcctg  acttccctg  1560
gggggtggt  cctgtcacc  ctgtgaccg  cgaggacga  gcccagatg  aactctaca  1620
aggctactt  ggggatatc  gggacatca  cctgaagaa  gccatgaaa  atagtgtcg  1680
tctgcctgt  gctgtgcag  gcgtggctc  gccctggca  gaagagctg  gtctgaggt  1740
catgcggga  gtggaacag  tgatgaccc  tcaaaagca  ccatcgtga  ggtcgttca  1800
ccgccagct  tggaggacc  aaggcccat  cgctgtgca  tgtagcccc  tgtattcag  1860
agccaccac  cacgaggga  cgcccagca  agggaagag  tgtctacct  ccctcccct  1920
gactcctgc  gccacaacc  agtctggac  ttcctcccc  ttatggtct  ctttccatc  1980
tgattccct  ctttttatg  cagccagca  gaatgacgt  ggccaagga  caccaacat  2040
caaaaacaa  gcgtttatc  attttctgg  tatctccat  agggccctg  gaaccagag  2100
gctgggaag  ctgtccaga  cctccagag  tggctgtaa  cacatcact  tcctgctcc  2160
aagcctccc  agttctgtc  cccacaaga  agacacagg  acatgtcct  ggcacttga  2220
tcctgtcct  cctttctta  tcagattga  cccagcctt  atggaccct  cccctgcac  2280
tccttcctc  gtccacctc  ctgccgaca  gcccttttt  tggctcctc  atttgttgt  2340
gagacaagg  ttctctcag  agccctggc  gtccaggac  tcactctgt  gatgaggct  2400
gctttcaac  cacaaggct  cctgcctgg  tgctgggat  aaaggcgta  gccaccaca  2460
agaaaaaaa  aa  2472



<210> 8857
<211> 579
<212> PRT
<213> Rattus norvegicus
<308> P97612
<400> 8857

Met Val Leu Ser Glu Val Trp Thr Thr Leu Ser Gly Val Ser Gly Val 
  1               5                  10                  15
Cys Leu Ala Cys Ser Leu Leu Ser Ala Ala Val Val Leu Arg Trp Thr 
             20                  25                  30
Gly Arg Gln Lys Ala Arg Gly Ala Ala Thr Arg Ala Arg Gln Lys Gln 
         35                  40                  45
Arg Ala Ser Leu Glu Thr Met Asp Lys Ala Val Gln Arg Phe Arg Leu 
     50                  55                  60
Gln Asn Pro Asp Leu Asp Ser Glu Ala Leu Leu Thr Leu Pro Leu Leu 
 65                  70                  75                  80
Gln Leu Val Gln Lys Leu Gln Ser Gly Glu Leu Ser Pro Glu Ala Val 
                 85                  90                  95
Phe Phe Thr Tyr Leu Gly Lys Ala Trp Glu Val Asn Lys Gly Thr Asn 
             100                105                110
Cys Val Thr Ser Tyr Leu Thr Asp Cys Glu Thr Gln Leu Ser Gln Ala 
         115                120                125
Pro Arg Gln Gly Leu Leu Tyr Gly Val Pro Val Ser Leu Lys Glu Cys 
     130                135                140
Phe Ser Tyr Lys Gly His Asp Ser Thr Leu Gly Leu Ser Leu Asn Glu 
 145                150                155                160
Gly Met Pro Ser Glu Ser Asp Cys Val Val Val Gln Val Leu Lys Leu 
                 165                170                175
Gln Gly Ala Val Pro Phe Val His Thr Asn Val Pro Gln Ser Met Leu 
             180                185                190
Ser Phe Asp Cys Ser Asn Pro Leu Phe Gly Gln Thr Met Asn Pro Trp 
         195                200                205
Lys Ser Ser Lys Ser Pro Gly Gly Ser Ser Gly Gly Glu Gly Ala Leu 
     210                215                220
Ile Gly Ser Gly Gly Ser Pro Leu Gly Leu Gly Thr Asp Ile Gly Gly 
 225                230                235                240
Ser Ile Arg Phe Pro Ser Ala Phe Cys Gly Ile Cys Gly Leu Lys Pro 
                 245                250                255
Thr Gly Asn Arg Leu Ser Lys Ser Gly Leu Lys Gly Cys Val Tyr Gly 
             260                265                270
Gln Thr Ala Val Gln Leu Ser Leu Gly Pro Met Ala Arg Asp Val Glu 
         275                280                285
Ser Leu Ala Leu Cys Leu Lys Ala Leu Leu Cys Glu His Leu Phe Thr 
     290                295                300
Leu Asp Pro Thr Val Pro Pro Leu Pro Phe Arg Glu Glu Val Tyr Arg 
 305                310                315                320
Ser Ser Arg Pro Leu Arg Val Gly Tyr Tyr Glu Thr Asp Asn Tyr Thr 
                 325                330                335
Met Pro Ser Pro Ala Met Arg Arg Ala Leu Ile Glu Thr Lys Gln Arg 
             340                345                350
Leu Glu Ala Ala Gly His Thr Leu Ile Pro Phe Leu Pro Asn Asn Ile 
         355                360                365
Pro Tyr Ala Leu Glu Val Leu Ser Ala Gly Gly Leu Phe Ser Asp Gly 
     370                375                380
Gly Arg Ser Phe Leu Gln Asn Phe Lys Gly Asp Phe Val Asp Pro Cys 
 385                390                395                400
Leu Gly Asp Leu Ile Leu Ile Leu Arg Leu Pro Ser Trp Phe Lys Arg 
                 405                410                415
Leu Leu Ser Leu Leu Leu Lys Pro Leu Phe Pro Arg Leu Ala Ala Phe 
             420                425                430
Leu Asn Ser Met Arg Pro Arg Ser Ala Glu Lys Leu Trp Lys Leu Gln 
         435                440                445
His Glu Ile Glu Met Tyr Arg Gln Ser Val Ile Ala Gln Trp Lys Ala 
     450                455                460
Met Asn Leu Asp Val Leu Leu Thr Pro Met Leu Gly Pro Ala Leu Asp 
 465                470                475                480
Leu Asn Thr Pro Gly Arg Ala Thr Gly Ala Ile Ser Tyr Thr Val Leu 
                 485                490                495
Tyr Asn Cys Leu Asp Phe Pro Ala Gly Val Val Pro Val Thr Thr Val 
             500                505                510
Thr Ala Glu Asp Asp Ala Gln Met Glu Leu Tyr Lys Gly Tyr Phe Gly 
         515                520                525
Asp Ile Trp Asp Ile Ile Leu Lys Lys Ala Met Lys Asn Ser Val Gly 
     530                535                540
Leu Pro Val Ala Val Gln Cys Val Ala Leu Pro Trp Gln Glu Glu Leu 
 545                550                555                560
Cys Leu Arg Phe Met Arg Glu Val Glu Gln Leu Met Thr Pro Gln Lys 
                 565                570                575
Gln Pro Ser 
             580



<210> 8858
<211> 1056
<212> DNA
<213> Homo sapiens
<308> AL050372
<400> 8858

cggaggcag  atccgcttc  cctcctcct  ctgcggcat  tgcggcctc  agcccacag  60
gaaccgcct  aggtctaca  cagctctca  cccctgcgt  tggggtact  tgagactga  120
aactatacc  tgccctccc  ggccatgag  cgggccgtg  tggagacca  acagagcct  180
gaggctgcg  ggcacacgc  ggttccctt  ttgccaagc  acatacccc  tgctctgga  240
accctgtca  caggtgggc  cttcagtga  ggtggccac  ccttcctac  gaacttcaa  300
ggtgatttc  tggacccct  cctggggga  ctggtctca  ttctgaagc  tccccaatg  360
cttaaagga  tgctggcct  cctggtgaa  cctctgctg  caaggctgt  agctttcct  420
agcaacatg  agtctcggt  taccgcaaa  ccgtgattg  ccagtggag  gcgctggac  480
tggatgtgg  gctgacccc  atgctggcc  ctgctctgg  cttgaatgc  ccaggcagg  540
ccacagggg  ggtgcctgt  accacggtg  ctgctgagg  cgaggccca  atggaacat  600
acaggggct  ctttgggga  atctgggac  agatgctgc  gaagggcat  aagaagagt  660
tggggctgc  ggtggccgt  cagtgtgtg  ctctgccct  gcaagaaga  ttgtgtctg  720
ggttcatgc  ggaggtgga  cgactgatg  cccctgaaa  gcagtcatc  tgatggctc  780
ggctccaga  gacctgaga  tcacactct  tgcagccca  cctagtcag  gcacagctg  840
cctgctgcc  cagcaagga  atgtcctgc  tggggcaga  gcttccgtg  cctctcccc  900
aaccccctg  aagaagcgc  gactccctg  gtctggacc  ccatccctg  tctggtccc  960
tctcttcgt  ctgatccct  cacccccat  tggcagccc  tgggtatga  ataggccaa  1020
gcccaacta  cagtcaaga  acagctaaa  aaaaaa  1056



<210> 8859
<211> 579
<212> PRT
<213> Homo sapiens
<308> O00519
<400> 8859

Met Val Gln Tyr Glu Leu Trp Ala Ala Leu Pro Gly Ala Ser Gly Val 
  1               5                  10                  15
Ala Leu Ala Cys Cys Phe Val Ala Ala Ala Val Ala Leu Arg Trp Ser 
             20                  25                  30
Gly Arg Arg Thr Ala Arg Gly Ala Val Val Arg Ala Arg Gln Lys Gln 
         35                  40                  45
Arg Ala Gly Leu Glu Asn Met Asp Arg Ala Ala Gln Arg Phe Arg Leu 
     50                  55                  60
Gln Asn Pro Asp Leu Asp Ser Glu Ala Leu Leu Ala Leu Pro Leu Pro 
 65                  70                  75                  80
Gln Leu Val Gln Lys Leu His Ser Arg Glu Leu Ala Pro Glu Ala Val 
                 85                  90                  95
Leu Phe Thr Tyr Val Gly Lys Ala Trp Glu Val Asn Lys Gly Thr Asn 
             100                105                110
Cys Val Thr Ser Tyr Leu Ala Asp Cys Glu Thr Gln Leu Ser Gln Ala 
         115                120                125
Pro Arg Gln Gly Leu Leu Tyr Gly Val Pro Val Ser Leu Lys Glu Cys 
     130                135                140
Phe Thr Tyr Lys Gly Gln Asp Ser Thr Leu Gly Leu Ser Leu Asn Glu 
 145                150                155                160
Gly Val Pro Ala Glu Cys Asp Ser Val Val Val His Val Leu Lys Leu 
                 165                170                175
Gln Gly Ala Val Pro Phe Val His Thr Asn Val Pro Gln Ser Met Phe 
             180                185                190
Ser Tyr Asp Cys Ser Asn Pro Leu Phe Gly Gln Thr Val Asn Pro Trp 
         195                200                205
Lys Ser Ser Lys Ser Pro Gly Gly Ser Ser Gly Gly Glu Gly Ala Leu 
     210                215                220
Ile Gly Ser Gly Gly Ser Pro Leu Gly Leu Gly Thr Asp Ile Gly Gly 
 225                230                235                240
Ser Ile Arg Phe Pro Ser Ser Phe Cys Gly Ile Cys Gly Leu Lys Pro 
                 245                250                255
Thr Gly Asn Arg Leu Ser Lys Ser Gly Leu Lys Gly Cys Val Tyr Gly 
             260                265                270
Gln Glu Ala Val Arg Leu Ser Val Gly Pro Met Ala Arg Asp Val Glu 
         275                280                285
Ser Leu Ala Leu Cys Leu Arg Ala Leu Leu Cys Glu Asp Met Phe Arg 
     290                295                300
Leu Asp Pro Thr Val Pro Pro Leu Pro Phe Arg Glu Glu Val Tyr Thr 
 305                310                315                320
Ser Ser Gln Pro Leu Arg Val Gly Tyr Tyr Glu Thr Asp Asn Tyr Thr 
                 325                330                335
Met Pro Ser Pro Ala Met Arg Arg Ala Val Leu Glu Thr Lys Gln Ser 
             340                345                350
Leu Glu Ala Ala Gly His Thr Leu Val Pro Phe Leu Pro Ser Asn Ile 
         355                360                365
Pro His Ala Leu Glu Thr Leu Ser Thr Gly Gly Leu Phe Ser Asp Gly 
     370                375                380
Gly His Thr Phe Leu Gln Asn Phe Lys Gly Asp Phe Val Asp Pro Cys 
 385                390                395                400
Leu Gly Asp Leu Val Ser Ile Leu Lys Leu Pro Gln Trp Leu Lys Gly 
                 405                410                415
Leu Leu Ala Phe Leu Val Lys Pro Leu Leu Pro Arg Leu Ser Ala Phe 
             420                425                430
Leu Ser Asn Met Lys Ser Arg Ser Ala Gly Lys Leu Trp Glu Leu Gln 
         435                440                445
His Glu Ile Glu Val Tyr Arg Lys Thr Val Ile Ala Gln Trp Arg Ala 
     450                455                460
Leu Asp Leu Asp Val Val Leu Thr Pro Met Leu Ala Pro Ala Leu Asp 
 465                470                475                480
Leu Asn Ala Pro Gly Arg Ala Thr Gly Ala Val Ser Tyr Thr Met Leu 
                 485                490                495
Tyr Asn Cys Leu Asp Phe Pro Ala Gly Val Val Pro Val Thr Thr Val 
             500                505                510
Thr Ala Glu Asp Glu Ala Gln Met Glu His Tyr Arg Gly Tyr Phe Gly 
         515                520                525
Asp Ile Trp Asp Lys Met Leu Gln Lys Gly Met Lys Lys Ser Val Gly 
     530                535                540
Leu Pro Val Ala Val Gln Cys Val Ala Leu Pro Trp Gln Glu Glu Leu 
 545                550                555                560
Cys Leu Arg Phe Met Arg Glu Val Glu Arg Leu Met Thr Pro Glu Lys 
                 565                570                575
Gln Ser Ser 
             580



<210> 8860
<211> 1070
<212> DNA
<213> Rattus norvegicus
<308> U72741
<400> 8860

aagagatgg  tttcttcag  acccagcct  catacatga  cccagtcat  ccctttact  60
gaataatcc  aggagggtt  cagaacgga  ttcagatca  cctccaggg  accgtccac  120
cttttccaa  taggattgc  gtgaacttt  agactggct  cagtggaaa  gacattgcc  180
tccacttca  tccccggtt  gaggaagga  gatatgtgg  ttgcaacac  aagcagaat  240
gaaagtggg  gcctgagga  aggaagatg  agatgccct  ccagaaggg  atgcccttt  300
agctttgct  cctggtaca  aggtcggaa  tcaaggtga  ggtgaacaa  aacttcttt  360
tacagtact  acaccgcgt  ccctaccac  tcgtggaca  catttcggt  tcgggatgc  420
tgcacctgt  cttcatcaa  ttccagaac  ccactgcag  ccctgtcca  cctgtcttc  480
ccacaatgc  attctctca  ccagtccag  tcccacgga  gcccaaggg  cgcaaacag  540
gaactcagg  ctttcagcc  gccctccag  cacccgtgg  tcaaactat  atccacaca  600
ttcacagca  ccctggaca  atgctctct  ctcctggaa  ccctcctat  gcatacccc  660
ccccagcct  tactatacc  ttcttcacc  gcatcccaa  tgggtttta  ccatccaag  720
ccatcaaca  atcaggcgt  gtcttgcca  atgctaaga  gttccatat  aaccttcgc  780
gtgggggtg  cattgcttt  cacctgaac  cccgtttca  tgagaaggt  gtggtccga  840
acactcaga  caacaactc  tgggggccc  aggagcgaa  cctgcctgg  agaatgccc  900
tcaatcgtg  ccagagttt  tcagtgtgg  tcttatgtg  aggtcactg  ttcaaggtg  960
ccgtggatg  tcagcatat  tgtgaatat  accaccgcc  gaagaactt  ccggatatc  1020
acactctag  ggtggccgg  gatatccag  tgacacacg  gcagacctag  1070



<210> 8861
<211> 354
<212> PRT
<213> Rattus norvegicus
<308> P97840
<400> 8861

Met Ala Phe Phe Ser Thr Gln Pro Pro Tyr Met Asn Pro Val Ile Pro 
  1               5                  10                  15
Phe Thr Gly Ile Ile Gln Gly Gly Leu Gln Asn Gly Leu Gln Ile Thr 
             20                  25                  30
Leu Gln Gly Thr Val His Pro Phe Pro Asn Arg Ile Ala Val Asn Phe 
         35                  40                  45
Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro Arg 
     50                  55                  60
Phe Glu Glu Gly Gly Tyr Val Val Cys Asn Thr Lys Gln Asn Gly Lys 
 65                  70                  75                  80
Trp Gly Pro Glu Glu Arg Lys Met Gln Met Pro Phe Gln Lys Gly Met 
                 85                  90                  95
Pro Phe Glu Leu Cys Phe Leu Val Gln Arg Ser Glu Phe Lys Val Met 
             100                105                110
Val Asn Lys Asn Phe Phe Val Gln Tyr Ser His Arg Val Pro Tyr His 
         115                120                125
Leu Val Asp Thr Ile Ser Val Ser Gly Cys Leu His Leu Ser Phe Ile 
     130                135                140
Asn Phe Gln Asn Ser Thr Ala Ala Pro Val Gln Pro Val Phe Ser Thr 
 145                150                155                160
Met Gln Phe Ser Gln Pro Val Gln Phe Pro Arg Met Pro Lys Gly Arg 
                 165                170                175
Lys Gln Arg Thr Gln Gly Phe Gln Pro Ala Leu Gln Ala Pro Val Ala 
             180                185                190
Gln Thr Ile Ile His Thr Val His Ser Ile Pro Gly Gln Met Leu Ser 
         195                200                205
Thr Pro Gly Ile Pro Pro Met Ala Tyr Pro Thr Pro Ala Tyr Thr Ile 
     210                215                220
Pro Phe Phe Thr Ser Ile Pro Asn Gly Phe Tyr Pro Ser Lys Ser Ile 
 225                230                235                240
Asn Ile Ser Gly Val Val Leu Pro Asp Ala Lys Arg Phe His Ile Asn 
                 245                250                255
Leu Arg Cys Gly Gly Asp Ile Ala Phe His Leu Asn Pro Arg Phe Asn 
             260                265                270
Glu Lys Val Val Val Arg Asn Thr Gln Ile Asn Asn Ser Trp Gly Pro 
         275                280                285
Glu Glu Arg Ser Leu Pro Gly Arg Met Pro Phe Asn Arg Gly Gln Ser 
     290                295                300
Phe Ser Val Trp Ile Leu Cys Glu Gly His Cys Phe Lys Val Ala Val 
 305                310                315                320
Asp Gly Gln His Ile Cys Glu Tyr Tyr His Arg Leu Lys Asn Leu Pro 
                 325                330                335
Asp Ile Asn Thr Leu Glu Val Ala Gly Asp Ile Gln Leu Thr His Val 
             340                345                350
Gln Thr 
         355



<210> 8862
<211> 440
<212> DNA
<213> Homo sapiens
<308> AA810306
<400> 8862

ttttttttt  ttgttaagt  gttccctct  caaaggact  cctagtggg  gtgaaaggc  60
gcggtggcc  cagaggcgg  ggagagatg  ccttcagcg  ttcccaggc  ccctacctg  120
gtccagctg  ccccttttc  gggactatt  aaggaggtc  ccaggacgg  cttcagatc  180
ctgtcaatg  gaccgttct  agctccagt  gaaccaggt  tgctgtgaa  tttcagact  240
gcttcagtg  aaatgacat  gccttccac  tcaaccctc  gtttgaaga  ggagggtac  300
tggtgtgca  cacgaggca  aacggaagc  gggggcccg  ggagaggaa  acacacatg  360
ctttccaga  ggggatgcc  tttgacctc  gcttcctgg  ggcgagctc  gatttcaag  420
tgatggtga  cgggatcctc  440



<210> 8863
<211> 355
<212> PRT
<213> Homo sapiens
<308> O00182
<400> 8863

Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
  1               5                  10                  15
Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
             20                  25                  30
Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
         35                  40                  45
Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
     50                  55                  60
Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
 65                  70                  75                  80
Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
                 85                  90                  95
Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
             100                105                110
Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
         115                120                125
His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
     130                135                140
Ile Ser Phe Gln Asn Pro Arg Thr Val Pro Val Gln Pro Ala Phe Ser 
 145                150                155                160
Thr Val Pro Phe Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly 
                 165                170                175
Arg Arg Gln Lys Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile 
             180                185                190
Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe 
         195                200                205
Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
     210                215                220
Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser 
 225                230                235                240
Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile 
                 245                250                255
Asn Leu Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe 
             260                265                270
Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly 
         275                280                285
Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln 
     290                295                300
Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala 
 305                310                315                320
Val Asp Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu 
                 325                330                335
Pro Thr Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His 
             340                345                350
Val Gln Thr 
         355



<210> 8864
<211> 5249
<212> DNA
<213> Rattus norvegicus
<308> U72995
<400> 8864

gaattctcg  acgaggcgc  ggctcgccg  ggcgctggg  taggaagcg  cgggcgctt  60
gcggttcgg  gacgtccgg  gggcctggc  ggttcctcg  agagtagat  ttatcaaga  120
tcctccctg  aacgctggc  ccttgctca  tgccctgaa  tctctctgc  atgaactga  180
acattggaa  catggtgca  aagaagttc  gccctcggt  acttgacta  ctagtgatc  240
taggggcca  gcatccaag  agtgacagt  tggctcaga  tcctgaact  ctgcggagg  300
acccactag  ggaccaccc  gagtttccc  tgcccccag  tgtggtgtt  ttctgccag  360
cagagggat  tctgagcgt  cggcaacgg  gcatgagcc  ccgagatga  acctctttt  420
tcttcaccc  aaccgataa  gacactgga  tcacccgtt  tggcatctg  gtcaacttc  480
accgttcct  tcaaaagcg  atgccaaag  aaaaggcgg  aggcggagc  ggaccccgt  540
ggaaggaag  agctcatgc  ccctgtgcc  cagaagagg  cgccaccga  agctcagag  600
gtggctcaa  cttgcagcc  cctagtgct  actccactc  tgacgtaaa  cagtctcct  660
ggggcaaac  tagggcaaa  gcaggcaac  gctcccgaa  cagtaccct  acatccctg  720
gtgtgctta  ccactaccc  ttcttctct  ccttcagag  gtgtctgta  actctcaaa  780
gtctggtag  ctgctgtag  gaacggctc  taggcaaga  accgggcat  cctcgaggt  840
tacaaaggg  caccatgtg  cgaatcttt  ctggatcac  gctagtgga  gagaagtcc  900
gtgcccttc  gcatgacct  cgagagatc  aggcctgga  ctatcggtt  ctacgctcc  960
cggtgcctg  ctctgggca  aagcgagtg  acattgagg  cctacccca  gaagtgcag  1020
aggccctga  atttgctct  ccagatcca  cccggttca  cctagtaga  ttccctctt  1080
accttccct  ggaacttct  ggtgtagat  cttgtcttc  ggtgctaac  tgcatcctg  1140
tggagcaca  ggtggtgct  cagtctcga  actacaacg  actctccat  tctgtgatg  1200
cgtttgtgg  aatgatcta  cccctggag  acatgttcc  tgtcatccc  ctgcttccc  1260
cctgcatgg  ttcggcaga  cagctactc  tggctccaa  cccatatat  attggagtc  1320
ctgccagct  tttcctcta  aagctagac  tcaaaatgc  tgatgacgt  tggctggtg  1380
atctggaca  caacagggt  attgccccc  ccaatgcag  agtgctacc  atcctgcca  1440
aaccggaat  attagagct  aaaaaacac  taaagcagg  tctagccag  atgagtctc  1500
acacccagc  cattcttaa  ctggagaaa  tccatgagg  ccaggagac  ccacttctc  1560
tgggaaggt  ttctaatga  cttcagtct  caccttcca  tgaattcaa  ccactcatt  1620
atggcaatg  tgtagattc  gtcgatgtt  caacgagag  ggccatggt  cgtttcttc  1680
actctgcta  cgtgctgca  ggctttcag  tgcacacac  taccctgcg  ctcttcccc  1740
ggcccgtgg  tgccttcca  gctggctcc  ttctggcct  acgcccccg  cagaccccc  1800
ttgctgaga  actggccag  actcaagcc  tggagtact  tggagaatg  atcctgaac  1860
cttctaact  tgccttcca  cggattcac  acaatacgt  tgatccagc  ctcattggt  1920
acaagccta  gtggtacgc  caccagctg  agcccattc  ctatcgagt  tatgacagc  1980
attctcagc  ggctgaggc  ctgagtgtg  caccggagc  tgattctga  tctgacccc  2040
ctgatgaca  tggcagtga  agcatggac  atgatgact  aagctcttc  tactcctcc  2100
tgggggact  cgtcagtga  atgatgaag  gtgacatca  tggcgacac  cccaatgtg  2160
atcctctga  gcatgcggc  ctgggagac  ccagtgaag  ggagattga  gagctgcag  2220
cccagaagg  gggagagga  cctggccca  acagtgaga  ctctcagga  aaccttccc  2280
tgcgctcca  ctccagcac  actgccagc  gtagcccta  caccatcgt  cacggcgcc  2340
actctgaac  tgctgattc  acagaggtg  gagataagg  agcaacagg  atctccaag  2400
ccctccctc  tgtgcctcc  agcatttgc  aatctactg  ggacaggag  cagacagag  2460
ctggagagg  gtcagtgtg  cagcgaacc  acgaccatc  atattttga  ccccaatat  2520
gctcccccg  tgaggaaga  gatgacgag  agggagaga  ctacacgcc  cggttcagc  2580
aacatgcca  tggcagtcg  gctcaaaag  tgctgcggc  caacagctt  aagctggcc  2640
gtgactcag  cgcagagtc  gactcccga  caagctctc  caactccac  gtctctaac  2700
acagcaccg  gggcttcgg  ggcatcatg  cttttgcta  cagcctgta  cggaaccat  2760
gtacaagct  cagcctttc  aacctcaca  tgcccacca  aggtgcccg  gagaagact  2820
caccattcc  cagcctgaa  ggaaacagg  gggccttag  ggaccagaa  tcatctgtc  2880
ttaaacaca  cccaactgt  aaaagagaa  ctccatcac  gcagggccg  tccagcaat  2940
ctagcgaga  ccaacagtt  ctgaaggag  tggtccaca  tgtgctgga  ggccaggga  3000
tcggctggc  caacatgaa  aaggtgcgc  ggctgctgg  gagtgagca  ctccgagtc  3060
ttgtactga  caagctgag  cgtgcagtg  agtcagagg  tgatgcccg  caggatgtc  3120
tccaggatg  ggagatcag  cggaaggtg  acaagggaa  gctagacct  ctcaagtgc  3180
cagtcctca  cctcgagca  tcctatgcc  atgctggtc  gggtggcat  gccagcatc  3240
ttgggcttt  ggagattgc  cagacccat  actatagta  agaaccaga  aaacgcaag  3300
gaagtccaa  agagaatgt  aatacccca  ttggcaagg  tcctggtct  gctgggcgg  3360
gggacccaa  ggcaatggc  cagctaagg  tccctcagc  gggtcctcg  gcaccaagt  3420
ctacaggaa  gggtcctaa  gaactggac  ccagaagtt  aaaggaaga  aattttgta  3480
cgtctgtgg  accagaggt  atcaagcct  tctttgacc  gggtgagac  gaggagaaa  3540
agtcccaga  cagcgcaga  agtggtgtg  gcctggcat  tgcttccca  aggactgat  3600
aagactctg  catcggtgt  agtccagct  ttatgatcc  aagctcaag  caggattct  3660
aagtgagta  cagttcagg  gagaccctc  gagcagaca  tgacctgag  agcaatgca  3720
gtgatgggc  aggaggcga  ggcagtgcc  acttggcaa  ttctcgggc  actctgtct  3780
acagtgaaa  tgaaaccaa  tctgctaca  gcaccatct  tggtaaagc  catagcttg  3840
agccaaagg  gaagccggc  agtagtcca  ttcgctctt  cgaagatgt  agccagcga  3900
tctatctct  tgagggact  ctaggaagg  acaaaggat  catgtggga  cagttagag  3960
atgctgcta  ggagacctt  tctataagc  aagagcggt  tactttatg  gaccaaatg  4020
agttctggg  agatgcgtt  ctagatgct  tgatgttgg  aagagaagg  atgggtatg  4080
accagggcc  tcaggaaat  atcgacagg  acctgtccc  aggagagca  gaccggaag  4140
gcctggagg  tgatgaaga  cgcttactg  ccacactct  acacaacct  atatcctat  4200
tgctcctga  gaaggtgaa  aagaacgac  tcaggaaga  agtacggcg  ctaatggga  4260
agtcccacg  tgggctggt  tacagtcaa  aaatcaatg  ggtgctcga  cagctgacc  4320
acctgaatg  gcgtgatct  tccatccga  ccagtggca  caggcacat  aagaagcag  4380
cgttcgttg  gcacgcagg  acggacaca  atggagata  ctttttcat  gaagtgtgt  4440
acgactgtg  ggtcttacg  agtaacatc  ggacagtgt  cgagcgctg  tggtatgag  4500
agcttatca  catgaccta  tgtcccaag  ccaaggtcc  gtgcttatg  cgtagaaat  4560
gctctgaga  gcagctcaa  aagttctat  ccaagaagt  tcgggagct  tactactgt  4620
tgaaggaca  catggagcg  gcggctgcc  ggcaacaaa  catcaaacc  gggcctgaa  4680
taggtggtg  gttccctgt  caggacatg  agactggag  gggcggctt  cttcaggtc  4740
ccctggaag  gatcaatct  aagttcatg  ataaccagg  tttcataga  ctgaatcac  4800
ttaaaaagt  caatacagt  cgaggcgtc  ttgtcctgg  agaatttgt  cctgaaatt  4860
aagaagtgg  gagccacaa  tacaagact  caatggccc  cgagatctg  tattctgtg  4920
tgtgtctct  ctcgtatgt  gccgcagtt  gtagcagtg  agaagacct  cgaacccca  4980
ctcggcctg  ctctagctg  tagagaggg  ttacacagc  gggccagcc  aggggtcac  5040
cctcacctc  tgctgctcc  aagcgctga  gctgcctcg  ctgagacag  gactctgtg  5100
gtgtgtgtg  gtgtgttct  tgcaaggtg  tctctgcaa  ctccttcct  cggttgagc  5160
ggtttcgtt  tatgtctga  tgtgtcctt  tgttcatct  tcatggggc  aagctagtc  5220
cattacctt  tcttcctac  atagcagac  5249



<210> 8865
<211> 1602
<212> PRT
<213> Rattus norvegicus
<308> AAC53149
<400> 8865

Met Val Gln Lys Lys Phe Cys Pro Arg Leu Leu Asp Tyr Leu Val Ile 
  1               5                  10                  15
Val Gly Ala Arg His Pro Ser Ser Asp Ser Val Ala Gln Thr Pro Glu 
             20                  25                  30
Leu Leu Arg Arg Tyr Pro Leu Glu Asp His Pro Glu Phe Pro Leu Pro 
         35                  40                  45
Pro Asp Val Val Phe Phe Cys Gln Pro Glu Gly Cys Leu Ser Val Arg 
     50                  55                  60
Gln Arg Arg Met Ser Leu Arg Asp Asp Thr Ser Phe Val Phe Thr Leu 
 65                  70                  75                  80
Thr Asp Lys Asp Thr Gly Val Thr Arg Tyr Gly Ile Cys Val Asn Phe 
                 85                  90                  95
Tyr Arg Ser Phe Gln Lys Arg Met Pro Lys Glu Lys Ala Glu Gly Gly 
             100                105                110
Ala Gly Pro Arg Gly Lys Glu Gly Ala His Ala Pro Cys Ala Ser Glu 
         115                120                125
Glu Ala Ala Thr Glu Ser Ser Glu Ser Gly Ser Thr Leu Gln Pro Pro 
     130                135                140
Ser Ala Asp Ser Thr Pro Asp Val Asn Gln Ser Pro Arg Gly Lys Arg 
 145                150                155                160
Arg Ala Lys Ala Gly Asn Arg Ser Arg Asn Ser Thr Leu Thr Ser Leu 
                 165                170                175
Cys Val Leu Ser His Tyr Pro Phe Phe Ser Thr Phe Arg Glu Cys Leu 
             180                185                190
Tyr Thr Leu Lys Arg Leu Val Asp Cys Cys Ser Glu Arg Leu Leu Gly 
         195                200                205
Lys Lys Pro Gly Ile Pro Arg Gly Val Gln Arg Asp Thr Met Trp Arg 
     210                215                220
Ile Phe Thr Gly Ser Leu Leu Val Glu Glu Lys Ser Ser Ala Leu Leu 
 225                230                235                240
His Asp Leu Arg Glu Ile Glu Ala Trp Ile Tyr Arg Leu Leu Arg Ser 
                 245                250                255
Pro Val Pro Val Ser Gly Gln Lys Arg Val Asp Ile Glu Val Leu Pro 
             260                265                270
Gln Glu Val Gln Gln Ala Leu Thr Phe Ala Leu Pro Asp Pro Ser Arg 
         275                280                285
Phe Thr Leu Val Asp Phe Pro Leu His Leu Pro Leu Glu Leu Leu Gly 
     290                295                300
Val Asp Ala Cys Leu Gln Val Leu Thr Cys Ile Leu Leu Glu His Lys 
 305                310                315                320
Val Val Leu Gln Ser Arg Asp Tyr Asn Ala Leu Ser Met Ser Val Met 
                 325                330                335
Ala Phe Val Ala Met Ile Tyr Pro Leu Glu Tyr Met Phe Pro Val Ile 
             340                345                350
Pro Leu Leu Pro Thr Cys Met Ala Ser Ala Glu Gln Leu Leu Leu Ala 
         355                360                365
Pro Thr Pro Tyr Ile Ile Gly Val Pro Ala Ser Phe Phe Leu Tyr Lys 
     370                375                380
Leu Asp Phe Lys Met Pro Asp Asp Val Trp Leu Val Asp Leu Asp Ser 
 385                390                395                400
Asn Arg Val Ile Ala Pro Thr Asn Ala Glu Val Leu Pro Ile Leu Pro 
                 405                410                415
Glu Pro Glu Ser Leu Glu Leu Lys Lys His Leu Lys Gln Ala Leu Ala 
             420                425                430
Ser Met Ser Leu Asn Thr Gln Pro Ile Leu Asn Leu Glu Lys Phe His 
         435                440                445
Glu Gly Gln Glu Thr Pro Leu Leu Leu Gly Arg Phe Ser Asn Asp Leu 
     450                455                460
Gln Ser Thr Pro Ser Thr Glu Phe Asn Pro Leu Ile Tyr Gly Asn Asp 
 465                470                475                480
Val Asp Ser Val Asp Val Ala Thr Arg Val Ala Met Val Arg Phe Phe 
                 485                490                495
Asn Ser Ala Asn Val Leu Gln Gly Phe Gln Met His Thr Arg Thr Leu 
             500                505                510
Arg Leu Phe Pro Arg Pro Val Val Ala Phe Gln Ala Gly Ser Phe Leu 
         515                520                525
Ala Ser Arg Pro Arg Gln Thr Pro Phe Ala Glu Lys Leu Ala Arg Thr 
     530                535                540
Gln Ala Val Glu Tyr Phe Gly Glu Trp Ile Leu Asn Pro Ser Asn Tyr 
 545                550                555                560
Ala Phe Gln Arg Ile His Asn Asn Thr Phe Asp Pro Ala Leu Ile Gly 
                 565                570                575
Asp Lys Pro Lys Trp Tyr Ala His Gln Leu Gln Pro Ile His Tyr Arg 
             580                585                590
Val Tyr Asp Ser Asn Ser Gln Leu Ala Glu Ala Leu Ser Val Pro Pro 
         595                600                605
Glu Arg Asp Ser Glu Ser Asp Pro Thr Asp Asp Ser Gly Ser Asp Ser 
     610                615                620
Met Asp Tyr Asp Asp Ser Ser Ser Ser Tyr Ser Ser Leu Gly Asp Phe 
 625                630                635                640
Val Ser Glu Met Met Lys Cys Asp Ile Asn Gly Asp Thr Pro Asn Val 
                 645                650                655
Asp Pro Leu Thr His Ala Ala Leu Gly Asp Ala Ser Glu Val Glu Ile 
             660                665                670
Asp Glu Leu Gln Pro Gln Lys Glu Gly Glu Glu Pro Gly Pro Asp Ser 
         675                680                685
Glu Asn Ser Gln Glu Asn Leu Pro Leu Arg Ser Ser Ser Ser Thr Thr 
     690                695                700
Ala Ser Ser Ser Pro Ser Thr Ile Val His Gly Ala His Ser Glu Pro 
 705                710                715                720
Ala Asp Ser Thr Glu Val Gly Asp Lys Ala Ala Thr Gly Ile Ser Lys 
                 725                730                735
Pro Leu Pro Pro Val Pro Pro Ser Ile Cys Lys Ser Thr Val Asp Arg 
             740                745                750
Arg Gln Thr Glu Thr Gly Glu Gly Ser Val Cys Gln Arg Thr Tyr Asp 
         755                760                765
His Pro Tyr Phe Glu Pro Gln Tyr Gly Ser Pro Ala Glu Glu Asp Asp 
     770                775                780
Asp Glu Gln Gly Glu Ser Tyr Thr Pro Arg Phe Ser Gln His Ala Ser 
 785                790                795                800
Gly Ser Arg Ala Gln Lys Leu Leu Arg Pro Asn Ser Leu Lys Leu Ala 
                 805                810                815
Ser Asp Ser Asp Ala Glu Ser Asp Ser Arg Ala Ser Ser Pro Asn Ser 
             820                825                830
Thr Val Ser Asn Asn Ser Thr Glu Gly Phe Gly Gly Ile Met Ser Phe 
         835                840                845
Ala Ser Ser Leu Tyr Arg Asn His Ser Thr Ser Phe Ser Leu Ser Asn 
     850                855                860
Leu Thr Leu Pro Thr Lys Gly Ala Arg Glu Lys Thr Thr Pro Phe Pro 
 865                870                875                880
Ser Leu Lys Gly Asn Arg Arg Ala Leu Val Asp Gln Lys Ser Ser Val 
                 885                890                895
Ile Lys His Ser Pro Thr Val Lys Arg Glu Pro Pro Ser Pro Gln Gly 
             900                905                910
Arg Ser Ser Asn Ser Ser Glu Asn Gln Gln Phe Leu Lys Glu Val Val 
         915                920                925
His Ser Val Leu Asp Gly Gln Gly Val Gly Trp Leu Asn Met Lys Lys 
     930                935                940
Val Arg Arg Leu Leu Glu Ser Glu Gln Leu Arg Val Phe Val Leu Ser 
 945                950                955                960
Lys Leu Ser Arg Ala Val Gln Ser Glu Asp Asp Ala Arg Gln Asp Val 
                 965                970                975
Ile Gln Asp Val Glu Ile Ser Arg Lys Val Tyr Lys Gly Met Leu Asp 
             980                985                990
Leu Leu Lys Cys Thr Val Leu Ser Leu Glu Gln Ser Tyr Ala His Ala 
         995                1000                1005
Gly Leu Gly Gly Met Ala Ser Ile Phe Gly Leu Leu Glu Ile Ala Gln 
     1010                1015                1020
Thr His Tyr Tyr Ser Lys Glu Pro Asp Lys Arg Lys Arg Ser Pro Thr 
 1025                1030                1035                1040
Glu Asn Val Asn Thr Pro Val Gly Lys Asp Pro Gly Leu Ala Gly Arg 
                 1045                1050                1055
Gly Asp Pro Lys Ala Met Ala Gln Leu Arg Val Pro Gln Leu Gly Pro 
             1060                1065                1070
Arg Ala Pro Ser Ala Thr Gly Arg Gly Pro Lys Glu Leu Asp Thr Arg 
         1075                1080                1085
Ser Leu Lys Glu Glu Asn Phe Val Ala Ser Val Gly Pro Glu Val Ile 
     1090                1095                1100
Lys Pro Val Phe Asp Leu Gly Glu Thr Glu Glu Lys Lys Ser Gln Ile 
 1105                1110                1115                1120
Ser Ala Asp Ser Gly Val Ser Leu Ala Ser Ala Ser Gln Arg Thr Asp 
                 1125                1130                1135
Gln Asp Ser Val Ile Gly Val Ser Pro Ala Val Met Ile Arg Ser Ser 
             1140                1145                1150
Ser Gln Asp Ser Glu Val Ser Asn Ser Ser Gly Glu Thr Leu Gly Ala 
         1155                1160                1165
Asp Ser Asp Leu Ser Ser Asn Ala Gly Asp Gly Pro Gly Gly Glu Gly 
     1170                1175                1180
Ser Ala His Leu Ala Ser Ser Arg Ala Thr Leu Ser Asp Ser Glu Ile 
 1185                1190                1195                1200
Glu Thr Asn Ser Ala Thr Ser Thr Ile Phe Gly Lys Ala His Ser Leu 
                 1205                1210                1215
Lys Pro Lys Glu Lys Pro Ala Ser Ser Pro Val Arg Ser Ser Glu Asp 
             1220                1225                1230
Val Ser Gln Arg Val Tyr Leu Tyr Glu Gly Leu Leu Gly Arg Asp Lys 
         1235                1240                1245
Gly Ser Met Trp Asp Gln Leu Glu Asp Ala Ala Met Glu Thr Phe Ser 
     1250                1255                1260
Ile Ser Lys Glu Arg Ser Thr Leu Trp Asp Gln Met Gln Phe Trp Glu 
 1265                1270                1275                1280
Asp Ala Phe Leu Asp Ala Val Met Leu Glu Arg Glu Gly Met Gly Met 
                 1285                1290                1295
Asp Gln Gly Pro Gln Glu Met Ile Asp Arg Tyr Leu Ser Leu Gly Glu 
             1300                1305                1310
His Asp Arg Lys Arg Leu Glu Asp Asp Glu Asp Arg Leu Leu Ala Thr 
         1315                1320                1325
Leu Leu His Asn Leu Ile Ser Tyr Met Leu Leu Met Lys Val Asn Lys 
     1330                1335                1340
Asn Asp Ile Arg Lys Lys Val Arg Arg Leu Met Gly Lys Ser His Val 
 1345                1350                1355                1360
Gly Leu Val Tyr Ser Gln Gln Ile Asn Glu Val Leu Asp Gln Leu Thr 
                 1365                1370                1375
Asn Leu Asn Gly Arg Asp Leu Ser Ile Arg Ser Ser Gly Ser Arg His 
             1380                1385                1390
Met Lys Lys Gln Thr Phe Val Val His Ala Gly Thr Asp Thr Asn Gly 
         1395                1400                1405
Asp Ile Phe Phe Met Glu Val Cys Asp Asp Cys Val Val Leu Arg Ser 
     1410                1415                1420
Asn Ile Gly Thr Val Tyr Glu Arg Trp Trp Tyr Glu Lys Leu Ile Asn 
 1425                1430                1435                1440
Met Thr Tyr Cys Pro Lys Thr Lys Val Leu Cys Leu Trp Arg Arg Asn 
                 1445                1450                1455
Gly Ser Glu Thr Gln Leu Asn Lys Phe Tyr Thr Lys Lys Cys Arg Glu 
             1460                1465                1470
Leu Tyr Tyr Cys Val Lys Asp Ser Met Glu Arg Ala Ala Ala Arg Gln 
         1475                1480                1485
Gln Ser Ile Lys Pro Gly Pro Glu Leu Gly Gly Glu Phe Pro Val Gln 
     1490                1495                1500
Asp Met Lys Thr Gly Glu Gly Gly Leu Leu Gln Val Thr Leu Glu Gly 
 1505                1510                1515                1520
Ile Asn Leu Lys Phe Met His Asn Gln Val Phe Ile Glu Leu Asn His 
                 1525                1530                1535
Ile Lys Lys Cys Asn Thr Val Arg Gly Val Phe Val Leu Glu Glu Phe 
             1540                1545                1550
Val Pro Glu Ile Lys Glu Val Val Ser His Lys Tyr Lys Thr Pro Met 
         1555                1560                1565
Ala His Glu Ile Cys Tyr Ser Val Leu Cys Leu Phe Ser Tyr Val Ala 
     1570                1575                1580
Ala Val Arg Ser Ser Glu Glu Asp Leu Arg Thr Pro Pro Arg Pro Val 
 1585                1590                1595                1600
Ser Ser 
                 1605



<210> 8866
<211> 5942
<212> DNA
<213> Homo sapiens
<308> AB002356
<400> 8866

ctggcgccc  ctcggagcg  cgccgcgct  gggagcgac  gacgccccg  tgccggggg  60
cgtcgggct  ggcctggcc  gtcccccag  gcttgggag  cttcgattt  cagaattcc  120
cctgggaat  ctgactcct  gcttggtgc  ctgatgctt  tctgagata  actgatgaa  180
tggaaccat  gtgcaaaag  agaagttct  tcctcggtt  cttgactat  tagtgatcg  240
aggggccag  cacccgagc  gtgatagcg  ggcccagac  cctgaattg  tacggcgat  300
ccccttgga  gatcacact  agtttcccc  gcccccaga  gtagtgttc  tctgccagc  360
cgagggctg  ctgagcgtg  ggcagcggc  catgagcct  cgggatgat  cctcttttg  420
cttcaccct  actgacaag  acactggag  cacgcgata  ggcatctgt  ttaacttct  480
ccgctcctt  caaaagcga  tctctaagg  gaaggggga  ggtggggca  ggtcccgtg  540
gaaggaagg  acccatgcc  cctgtgcct  agaagaggg  ggcactgag  gctcagaga  600
tggctcatc  ctgcagcct  tcagtgctg  ctctacccc  gatgtgaac  agtctcctc  660
gggcaaacg  cgggccaag  cggggagcc  ctcccgcaa  agtactctc  cgtccctgt  720
cgtgctcag  cactaccct  tcttctcca  cttccgaga  tgtttgtat  ctctcaagc  780
cctggtgga  tgctgtagt  agcgccttc  gggcaagaa  ctgggcatc  ctcgaggcg  840
acaaaggga  accatgtgg  ggatcttta  tggatcgct  ctggtagag  agaagtcaa  900
tgcccttct  catgacctt  gagagattg  ggcctggat  tatcgattg  tgcgctccc  960
agtacccgt  tctgggcag  agcgagtag  catcgaggt  ctaccccaa  agctccagc  1020
agctctgac  tttgctctt  cagacccat  tcgattcac  ctagtggat  tcccactgc  1080
ccttccctt  gaacttcta  gtgtggacg  ctgtctcca  gtgctaacc  gcattctgt  1140
agagcacaa  gtggtgcta  agtcccgag  ctacaatgc  ctctccatg  ctgtgatgg  1200
attcgtggc  atgatctac  cactggaat  tatgtttcc  gtcatcccg  tgctaccca  1260
ctgcatggc  tcagcagag  agctgctgt  ggctccaac  ccgtacatc  ttggggttc  1320
tgccagctt  ttcctctac  aactggact  caaaatgcc  gatgatgta  ggctagtgg  1380
tctggacag  aatagggtg  ttgccccca  caatgcaga  gtgctgcct  tcctgccag  1440
accagaatc  ctagagctg  aaaagcatt  aaagcaggc  ttggccagc  tgagtctca  1500
cacccagcc  atcctcaat  tggagaaat  tcatgaggg  caggagatc  cccttctct  1560
gggaaggcc  tctaatgac  tgcagtcca  accgtccac  gaattcaac  cactcatct  1620
tggcaacga  gtggattct  tggatgttg  aaccagggt  gccatggta  ggttcttca  1680
ttccgccaa  gtgctgcag  gatttcaga  gcacacgcg  accctgcgc  tctttcctc  1740
gcctgtggt  gcttttcaa  ctggctcct  tctagcctc  cgtccccgg  agactcctt  1800
tgccgagaa  ttggccagg  ctcaggctg  ggagtactt  ggggaatgg  tccttaacc  1860
caccaacta  gcctttcag  gaattcaca  caatatgtt  gatccagcc  tgattggtg  1920
caagccaaa  tggtatgct  atcagctgc  gcctatcca  tatcgcgtc  atgacagca  1980
ttcccagct  gctgaggcc  tgagtgtac  accagagcg  gactctgac  ccgaaccta  2040
tgatgatag  ggcagtgat  gtatggatt  tgacgattc  agctcttct  actcctccc  2100
tggtgactt  gtcagtgaa  tgatgaaat  tgacattaa  ggtgatact  ccaatgtgg  2160
ccctctgac  catgcagca  tgggggatg  cagcgaggt  gagattgac  agctgcaga  2220
tcagaagga  gcagaagag  ctggcccag  cagtgagaa  tctcaggaa  accccccac  2280
gcgctccag  tctagcacc  cagccagca  cagccccag  actgtcatc  acggagcca  2340
ctctgaacc  gctgactct  cggagatgg  tgataaggc  gcagtaggc  tctccaagc  2400
cctcccttc  gtgcctccc  gcattggca  atcgaacgt  gacagacgt  aggcagaaa  2460
tggagaggg  tcagtgcgc  ggcgaatct  tgacaatcc  tacttcgag  cccaatatg  2520
ctttccccc  gaggaagat  aggatgagc  gggggaaag  tacactccc  gattcagcc  2580
acatgtcag  ggcaatcgg  ctcaaaagc  gctgcggcc  aacagcttg  gactggcaa  2640
tgactcaga  gcagagtca  actctcggg  aagctctcc  aactccacc  tctccaaca  2700
cagcaccga  ggcttcggg  gcatcatgt  ttttgccag  agcctctat  ggaaccaca  2760
taccagctt  agtctttca  acctcacac  gcccaccaa  ggtgcccga  agaaggcca  2820
gcccttccc  agtctgaaa  tatttgggc  aaatactct  atggagatt  ttactgaag  2880
cggccccgg  agtggtgaa  gaaacagga  ggcgttagt  gatcagaag  catctgtca  2940
taaacacag  ccaacagtg  aaagagaac  tccatcacc  cagggtcga  ccagcaatt  3000
tagtgagaa  cagcagttc  tgaaggagg  ggtgcacag  gtgctggac  gccagggag  3060
tggctggct  aacatgaaa  aggtgcgcc  gctgctgga  agcgagcag  tgcgagtct  3120
tgtcctgag  aagctgaac  gcatggtgc  gtcagagga  gatgcccgg  aggacatca  3180
cccggatgt  gagatcagt  ggaaggtgt  caagggaat  ttagacctc  tcaagtgta  3240
agtcctcag  ttggagcag  cctatgccc  cgcgggtct  ggtggcatg  ccagcatct  3300
tgggctttt  gagattgcc  agacccact  ctatagtaa  gaaccagac  agcggaaga  3360
aagtccaac  gaaagtgta  ataccccag  tggcaagga  cctggccta  ctgggcggg  3420
ggacccaaa  gctatggca  aactgagag  tccacaact  ggacctcgg  caccaagtg  3480
cacaggaaa  ggtcctaag  aactggaca  cagaagttt  aaggaagaa  attttatag  3540
atctattga  ttgtggaac  agcaccagg  agtgaaaaa  caaaaagct  tggaaaaac  3600
gaggcctga  gtaatcaaa  ctgtctttg  ccttggtga  acagaggag  aaaagtccc  3660
gatcagcgc  gacagtggt  tgagcctga  gtctagttc  cagaggact  atcaagact  3720
tgtcatcgg  gtgagtcca  ctgttatga  ccgcagctc  agtcaggat  ctgaagtta  3780
caccgtggt  agtaatagc  ctggagaga  ccttggagc  gacagtgac  tgagcagca  3840
tgcaggtga  ggaccaggt  gcgagggca  tgttcacct  gcaagctct  ggggcactt  3900
gtctgatag  gaaattgag  ccaactctg  cacaagcac  atctttggt  aagcccaca  3960
cttgaagcc  agcataaag  agaagctgg  aggcagccc  attcgtact  ctgaagatg  4020
gagccagcg  gtctatctc  atgagggac  cctaggaag  gacaaagga  ccatgtggg  4080
ccagttaga  gatgcagct  tggagacct  ttctataag  aaagagcgt  ctactttat  4140
ggaccaaat  caattctgg  aagatgcct  cttagatgc  gtgatgttg  agagagaag  4200
gatgggtat  gaccagggt  cccaggaaa  gatcgacag  tacctgtcc  ttggagaac  4260
tgaccggaa  cgcctggaa  atgatgaag  tcgcttgct  gccacactt  tgcacaacc  4320
catctccta  atgctgctg  tgaaggtaa  taagaatga  atccgcaag  aggtgaggc  4380
cctaatggg  aagtcgcac  ttgggcttg  gtacagcca  caaatcaat  aggtgcttg  4440
tcagctggc  aacctgaat  gacgcgatc  ctctatctg  tccagtggc  gccggcaca  4500
gaagaagca  acatttgtg  tacatgcag  gacagatac  aacggagat  tctttttca  4560
ggaggtgtg  gatgactgt  tggtgttgc  tagtaacat  ggaacagtg  atgagcgct  4620
gtggtacga  aagctcatc  acatgacct  ctgtcccaa  acgaaggtg  tgtgcttgt  4680
gcgtagaaa  ggctctgag  cccagctca  caagttcta  actaaaaag  gtcgggagc  4740
gtactactg  gtgaaggac  gcatggagc  cgctgccgc  cgacagcaa  gcatcaaac  4800
cggacctga  ttgggtggc  agttccctg  gcaggacct  aagactggt  agggtggcc  4860
gctgcaggt  accctggaa  ggatcaacc  caaattcat  cacaatcag  tcctgaaat  4920
aaagaagtg  tgagccaca  gtacaagac  ccaatggcc  acgaaatct  ctactccgt  4980
ttatgtctc  tctcgtacg  ggctgcagt  catagcagt  aggaagatc  cagaacccc  5040
ccccggcct  tctctagct  atggagagg  gctacgcag  tgccccagc  cagggcacg  5100
ccctggccc  ttgctgttc  caagtgcac  atgctgctg  gactgagga  tggatgatg  5160
tcgtgtgtc  tctgcaagc  ccctgctgt  gcttggttg  ttaccggtt  tgtgtccct  5220
tgagtgtgt  ttgagcgtg  ccaccttct  cctctccac  cccagaaga  caaactgcc  5280
tcccctcag  gctcaagaa  gtgtacagt  tgtggggcc  gtgtgaacc  actattttg  5340
gtccttgag  catttgtgt  gtggttcct  gtccttgtc  ctggcgtta  aactgtcca  5400
tgcaagagt  tggctctcc  ttctctgtg  cccggcatg  ctgggcgcc  ggagcagtt  5460
cactctgtg  ggagtgagg  aaccctggg  ctcaccctc  cagaggaag  gcacagaga  5520
gaagggaag  attgggggg  agccggagt  agtggcagc  tccctgctt  cttctgcat  5580
cccaagccg  cagctactg  ccagggccc  cagtgttgg  tgctgcctg  cacagcctc  5640
gtgactgca  tggagcggc  aattccctg  ggcctgcca  gccttcggc  tcagaggat  5700
gagtggtcg  ggctagtgg  gtcccaggg  ccgctggct  ctctgcctg  gcatcaggg  5760
gggggcagg  aagaccaag  tgggtttgc  catctgtct  caggctgtc  ctccaggca  5820
ggggtgtca  gagggagag  cagcctggg  atgggcaag  aatgactgt  aatatttca  5880
ccccacatt  tttatagaa  atgtacagt  gtgtgaatg  gaaataaat  tcctcaact  5940
cc  5942



<210> 8867
<211> 1582
<212> PRT
<213> Homo sapiens
<308> AB002356
<400> 8867

Met Val Gln Lys Lys Lys Phe Cys Pro Arg Leu Leu Asp Tyr Leu Val 
  1               5                  10                  15
Ile Val Gly Ala Arg His Pro Ser Ser Asp Ser Val Ala Gln Thr Pro 
             20                  25                  30
Glu Leu Leu Arg Arg Tyr Pro Leu Glu Asp His Thr Glu Phe Pro Leu 
         35                  40                  45
Pro Pro Asp Val Val Phe Phe Cys Gln Pro Glu Gly Cys Leu Ser Val 
     50                  55                  60
Arg Gln Arg Arg Met Ser Leu Arg Asp Asp Thr Ser Phe Val Phe Thr 
 65                  70                  75                  80
Leu Thr Asp Lys Asp Thr Gly Val Thr Arg Tyr Gly Ile Cys Val Asn 
                 85                  90                  95
Phe Tyr Arg Ser Phe Gln Lys Arg Ile Ser Lys Glu Lys Gly Glu Gly 
             100                105                110
Gly Ala Gly Ser Arg Gly Lys Glu Gly Thr His Ala Thr Cys Ala Ser 
         115                120                125
Glu Glu Gly Gly Thr Glu Ser Ser Glu Ser Gly Ser Ser Leu Gln Pro 
     130                135                140
Leu Ser Ala Asp Ser Thr Pro Asp Val Asn Gln Ser Pro Arg Gly Lys 
 145                150                155                160
Arg Arg Ala Lys Ala Gly Ser Arg Ser Arg Asn Ser Thr Leu Thr Ser 
                 165                170                175
Leu Cys Val Leu Ser His Tyr Pro Phe Phe Ser Thr Phe Arg Glu Cys 
             180                185                190
Leu Tyr Thr Leu Lys Arg Leu Val Asp Cys Cys Ser Glu Arg Leu Leu 
         195                200                205
Gly Lys Lys Leu Gly Ile Pro Arg Gly Val Gln Arg Asp Thr Met Trp 
     210                215                220
Arg Ile Phe Thr Gly Ser Leu Leu Val Glu Glu Lys Ser Ser Ala Leu 
 225                230                235                240
Leu His Asp Leu Arg Glu Ile Glu Ala Trp Ile Tyr Arg Leu Leu Arg 
                 245                250                255
Ser Pro Val Pro Val Ser Gly Gln Lys Arg Val Asp Ile Glu Val Leu 
             260                265                270
Pro Gln Glu Leu Gln Pro Ala Leu Thr Phe Ala Leu Pro Asp Pro Ser 
         275                280                285
Arg Phe Thr Leu Val Asp Phe Pro Leu His Leu Pro Leu Glu Leu Leu 
     290                295                300
Gly Val Asp Ala Cys Leu Gln Val Leu Thr Cys Ile Leu Leu Glu His 
 305                310                315                320
Lys Val Val Leu Gln Ser Arg Asp Tyr Asn Ala Leu Ser Met Ser Val 
                 325                330                335
Met Ala Phe Val Ala Met Ile Tyr Pro Leu Glu Tyr Met Phe Pro Val 
             340                345                350
Ile Pro Leu Leu Pro Thr Cys Met Ala Ser Ala Glu Gln Leu Leu Leu 
         355                360                365
Ala Pro Thr Pro Tyr Ile Ile Gly Val Pro Ala Ser Phe Phe Leu Tyr 
     370                375                380
Lys Leu Asp Phe Lys Met Pro Asp Asp Val Trp Leu Val Asp Leu Asp 
 385                390                395                400
Ser Asn Arg Val Ile Ala Pro Thr Asn Ala Glu Val Leu Pro Ile Leu 
                 405                410                415
Pro Glu Pro Glu Ser Leu Glu Leu Lys Lys His Leu Lys Gln Ala Leu 
             420                425                430
Ala Ser Met Ser Leu Asn Thr Gln Pro Ile Leu Asn Leu Glu Lys Phe 
         435                440                445
His Glu Gly Gln Glu Ile Pro Leu Leu Leu Gly Arg Pro Ser Asn Asp 
     450                455                460
Leu Gln Ser Thr Pro Ser Thr Glu Phe Asn Pro Leu Ile Tyr Gly Asn 
 465                470                475                480
Asp Val Asp Ser Val Asp Val Ala Thr Arg Val Ala Met Val Arg Phe 
                 485                490                495
Phe Asn Ser Ala Asn Val Leu Gln Gly Phe Gln Met His Thr Arg Thr 
             500                505                510
Leu Arg Leu Phe Pro Arg Pro Val Val Ala Phe Gln Ala Gly Ser Phe 
         515                520                525
Leu Ala Ser Arg Pro Arg Gln Thr Pro Phe Ala Glu Lys Leu Ala Arg 
     530                535                540
Thr Gln Ala Val Glu Tyr Phe Gly Glu Trp Ile Leu Asn Pro Thr Asn 
 545                550                555                560
Tyr Ala Phe Gln Arg Ile His Asn Asn Met Phe Asp Pro Ala Leu Ile 
                 565                570                575
Gly Asp Lys Pro Lys Trp Tyr Ala His Gln Leu Gln Pro Ile His Tyr 
             580                585                590
Arg Val Tyr Asp Ser Asn Ser Gln Leu Ala Glu Ala Leu Ser Val Pro 
         595                600                605
Pro Glu Arg Asp Ser Asp Ser Glu Pro Thr Asp Asp Ser Gly Ser Asp 
     610                615                620
Ser Met Asp Tyr Asp Asp Ser Ser Ser Ser Tyr Ser Ser Leu Gly Asp 
 625                630                635                640
Phe Val Ser Glu Met Met Lys Cys Asp Ile Asn Gly Asp Thr Pro Asn 
                 645                650                655
Val Asp Pro Leu Thr His Ala Ala Leu Gly Asp Ala Ser Glu Val Glu 
             660                665                670
Ile Asp Glu Leu Gln Asn Gln Lys Glu Ala Glu Glu Pro Gly Pro Asp 
         675                680                685
Ser Glu Asn Ser Gln Glu Asn Pro Pro Leu Arg Ser Ser Ser Ser Thr 
     690                695                700
Thr Ala Ser Ser Ser Pro Ser Thr Val Ile His Gly Ala Asn Ser Glu 
 705                710                715                720
Pro Ala Asp Ser Thr Glu Met Asp Asp Lys Ala Ala Val Gly Val Ser 
                 725                730                735
Lys Pro Leu Pro Ser Val Pro Pro Ser Ile Gly Lys Ser Asn Val Asp 
             740                745                750
Arg Arg Gln Ala Glu Ile Gly Glu Gly Ser Val Arg Arg Arg Ile Tyr 
         755                760                765
Asp Asn Pro Tyr Phe Glu Pro Gln Tyr Gly Phe Pro Pro Glu Glu Asp 
     770                775                780
Glu Asp Glu Gln Gly Glu Ser Tyr Thr Pro Arg Phe Ser Gln His Val 
 785                790                795                800
Ser Gly Asn Arg Ala Gln Lys Leu Leu Arg Pro Asn Ser Leu Arg Leu 
                 805                810                815
Ala Ser Asp Ser Asp Ala Glu Ser Asp Ser Arg Ala Ser Ser Pro Asn 
             820                825                830
Ser Thr Val Ser Asn Thr Ser Thr Glu Gly Phe Gly Gly Ile Met Ser 
         835                840                845
Phe Ala Ser Ser Leu Tyr Arg Asn His Ser Thr Ser Phe Ser Leu Ser 
     850                855                860
Asn Leu Thr Leu Pro Thr Lys Gly Ala Arg Glu Lys Ala Thr Pro Phe 
 865                870                875                880
Pro Ser Leu Lys Val Phe Gly Leu Asn Thr Leu Met Glu Ile Val Thr 
                 885                890                895
Glu Ala Gly Pro Gly Ser Gly Glu Gly Asn Arg Arg Ala Leu Val Asp 
             900                905                910
Gln Lys Ser Ser Val Ile Lys His Ser Pro Thr Val Lys Arg Glu Pro 
         915                920                925
Pro Ser Pro Gln Gly Arg Ser Ser Asn Ser Ser Glu Asn Gln Gln Phe 
     930                935                940
Leu Lys Glu Val Val His Ser Val Leu Asp Gly Gln Gly Val Gly Trp 
 945                950                955                960
Leu Asn Met Lys Lys Val Arg Arg Leu Leu Glu Ser Glu Gln Leu Arg 
                 965                970                975
Val Phe Val Leu Ser Lys Leu Asn Arg Met Val Gln Ser Glu Asp Asp 
             980                985                990
Ala Arg Gln Asp Ile Ile Pro Asp Val Glu Ile Ser Arg Lys Val Tyr 
         995                1000                1005
Lys Gly Met Leu Asp Leu Leu Lys Cys Thr Val Leu Ser Leu Glu Gln 
     1010                1015                1020
Ser Tyr Ala His Ala Gly Leu Gly Gly Met Ala Ser Ile Phe Gly Leu 
 1025                1030                1035                1040
Leu Glu Ile Ala Gln Thr His Tyr Tyr Ser Lys Glu Pro Asp Lys Arg 
                 1045                1050                1055
Lys Arg Ser Pro Thr Glu Ser Val Asn Thr Pro Val Gly Lys Asp Pro 
             1060                1065                1070
Gly Leu Ala Gly Arg Gly Asp Pro Lys Ala Met Ala Gln Leu Arg Val 
         1075                1080                1085
Pro Gln Leu Gly Pro Arg Ala Pro Ser Ala Thr Gly Lys Gly Pro Lys 
     1090                1095                1100
Glu Leu Asp Thr Arg Ser Leu Lys Glu Glu Asn Phe Ile Ala Ser Ile 
 1105                1110                1115                1120
Glu Leu Trp Asn Lys His Gln Glu Val Lys Lys Gln Lys Ala Leu Glu 
                 1125                1130                1135
Lys Gln Arg Pro Glu Val Ile Lys Pro Val Phe Asp Leu Gly Glu Thr 
             1140                1145                1150
Glu Glu Lys Lys Ser Gln Ile Ser Ala Asp Ser Gly Val Ser Leu Thr 
         1155                1160                1165
Ser Ser Ser Gln Arg Thr Asp Gln Asp Ser Val Ile Gly Val Ser Pro 
     1170                1175                1180
Ala Val Met Ile Arg Ser Ser Ser Gln Asp Ser Glu Val Ser Thr Val 
 1185                1190                1195                1200
Val Ser Asn Ser Ser Gly Glu Thr Leu Gly Ala Asp Ser Asp Leu Ser 
                 1205                1210                1215
Ser Asn Ala Gly Asp Gly Pro Gly Gly Glu Gly Ser Val His Leu Ala 
             1220                1225                1230
Ser Ser Arg Gly Thr Leu Ser Asp Ser Glu Ile Glu Thr Asn Ser Ala 
         1235                1240                1245
Thr Ser Thr Ile Phe Gly Lys Ala His Ser Leu Lys Pro Ser Ile Lys 
     1250                1255                1260
Glu Lys Leu Ala Gly Ser Pro Ile Arg Thr Ser Glu Asp Val Ser Gln 
 1265                1270                1275                1280
Arg Val Tyr Leu Tyr Glu Gly Leu Leu Gly Arg Asp Lys Gly Ser Met 
                 1285                1290                1295
Trp Asp Gln Leu Glu Asp Ala Ala Met Glu Thr Phe Ser Ile Ser Lys 
             1300                1305                1310
Glu Arg Ser Thr Leu Trp Asp Gln Met Gln Phe Trp Glu Asp Ala Phe 
         1315                1320                1325
Leu Asp Ala Val Met Leu Glu Arg Glu Gly Met Gly Met Asp Gln Gly 
     1330                1335                1340
Pro Gln Glu Met Ile Asp Arg Tyr Leu Ser Leu Gly Glu His Asp Arg 
 1345                1350                1355                1360
Lys Arg Leu Glu Asp Asp Glu Asp Arg Leu Leu Ala Thr Leu Leu His 
                 1365                1370                1375
Asn Leu Ile Ser Tyr Met Leu Leu Met Lys Val Asn Lys Asn Asp Ile 
             1380                1385                1390
Arg Lys Lys Val Arg Arg Leu Met Gly Lys Ser His Ile Gly Leu Val 
         1395                1400                1405
Tyr Ser Gln Gln Ile Asn Glu Val Leu Asp Gln Leu Ala Asn Leu Asn 
     1410                1415                1420
Gly Arg Asp Leu Ser Ile Trp Ser Ser Gly Ser Arg His Met Lys Lys 
 1425                1430                1435                1440
Gln Thr Phe Val Val His Ala Gly Thr Asp Thr Asn Gly Asp Ile Phe 
                 1445                1450                1455
Phe Met Glu Val Cys Asp Asp Cys Val Val Leu Arg Ser Asn Ile Gly 
             1460                1465                1470
Thr Val Tyr Glu Arg Trp Trp Tyr Glu Lys Leu Ile Asn Met Thr Tyr 
         1475                1480                1485
Cys Pro Lys Thr Lys Val Leu Cys Leu Trp Arg Arg Asn Gly Ser Glu 
     1490                1495                1500
Thr Gln Leu Asn Lys Phe Tyr Thr Lys Lys Cys Arg Glu Leu Tyr Tyr 
 1505                1510                1515                1520
Cys Val Lys Asp Ser Met Glu Arg Ala Ala Ala Arg Gln Gln Ser Ile 
                 1525                1530                1535
Lys Pro Gly Pro Glu Leu Gly Gly Glu Phe Pro Val Gln Asp Leu Lys 
             1540                1545                1550
Thr Gly Glu Gly Gly Leu Leu Gln Val Thr Leu Glu Gly Ile Asn Leu 
         1555                1560                1565
Lys Phe Met His Asn Gln Phe Leu Lys Leu Lys Lys Trp Ter 
     1570                1575                1580



<210> 8868
<211> 3132
<212> DNA
<213> Rattus norvegicus
<308> U73142
<400> 8868

gccgctgga  aatgtcgca  gaaaggccc  cgttctacc  gcaggagct  aacaagacc  60
tctgggagg  gcccgagcg  taccagaac  tgtccccgg  gggctcggg  gcctacggc  120
cggtgtgtg  tgcttttga  acaaagacg  gacatcgtg  ggcagtgaa  aagctgtcg  180
gaccgtttc  gtccatcat  cacgccaaa  ggacctaca  ggagctgcg  ctgctgaag  240
acatgaagc  cgagaatgt  attggtctg  tggatgtgt  tacacctgc  aggtccctg  300
aagaattca  cgatgtgta  ctggtgacc  atctcatgg  ggcagacct  aacaacatc  360
tgaagtgtc  gaagcttac  gatgaccac  ttcagtttc  tatctacca  atcctgcga  420
ggctgaagt  tatacactc  gctgacata  tccacaggg  cctaaagcc  agcaacctc  480
ctgtgaatg  agactgtga  ctgaagatt  tggattttg  gctggctcg  cacactgat  540
acgaaatga  cggctacgt  gctacccgg  ggtacagag  ccccgagat  atgctgaat  600
ggatgcact  caaccagac  gtggatatt  ggtccgtgg  ctgcatcat  gctgagctg  660
tgaccggaa  aacgttgtt  cctggtaca  accatattg  tcagttgaa  ctcatttta  720
gactcgttg  aaccccagg  gctgagctt  tgaagaaaa  ctcctcaga  tctgcaaga  780
actacattc  gtctctggc  cagatgccg  agatgaact  cgcaaatgt  tttattggt  840
ccaatcccc  ggctgtcga  ctgctggaa  agatgctgg  tttggactc  gataagagg  900
tcacagcag  ccaagctct  gcgcatgcc  actttgctc  gtaccacga  cctgatgat  960
agccagtgg  tgaacctta  gaccagtcc  ttgaaagca  ggacttcct  atagacgaa  1020
ggaagagcc  gacctacga  gaagtcatt  gctttgtgc  accgcccct  gaccaagaa  1080
aaatggagt  ctgagcacc  tgcttctgt  ctgtccatc  cacttcact  tgaggggaa  1140
gcctgttca  gggaactct  caaatacca  tcaagtgcc  cttgttgaa  gattccttc  1200
tggtggaag  gggtgcatg  atgtgcgta  tgtttgtgt  tgtctgtct  tctgtccgt  1260
tgtccatgt  tctttgtgg  agtcattgt  atggcagtg  cttcatgag  ggtagatgc  1320
ccttggcag  ctgcctgct  tctcagagt  cgggcaggc  gatgggaac  gccgtctcc  1380
tagggatgt  tgtgtgtat  ttaagtgca  agtaagaat  ttaaaatat  cctgttcct  1440
gttaccttg  cacttcggc  tctcctgtg  ccctgcctt  accatatca  agtgacaga  1500
agaggctgc  tcaggtctg  ggctatccc  cagccatgc  taaagccca  gagaaccaa  1560
tggctcctg  gctctagcc  gtgatcggc  tgctcatgt  ctcagaacc  gtcagtctg  1620
ttgtgcctt  aaaggagag  agggcgcgt  gtggtagtt  cagaatctc  gttgctggc  1680
ttctgagcc  ggcaaggca  agggctgtt  gatggccag  ggggagctg  acaaaacaa  1740
gcagccttc  aggaggcca  gggtgcatg  ttgcatgag  gtatgtgca  ccgccctcc  1800
tcacctcca  gagcaagct  ttttctatg  ttacctaag  tcacctcag  gcagaggtc  1860
ccagtgcca  gcacaggct  ctgccatca  tagcttcct  tgtcatctt  acgtcatgc  1920
ggtgtttgc  tgctgtgct  tggagcttg  cctgtcttc  ggaagccct  ggccgggcg  1980
gtgaagact  cccagcagt  ctatccacg  acctcagct  aggccacgg  cacactgct  2040
cttcctcac  ccagctacg  tgtgttgaa  acaactgat  ctccaggtg  ttgtggtgc  2100
ggaaacggg  cgaacagag  acctgaacc  ttgccatct  acatcaccg  cacaggaga  2160
cagtcctct  ctctcctct  ctctcctct  ctaggacag  ccccggctc  ggaatcatg  2220
tcttctcac  catggtagc  agctaagaa  gctgcaaac  gaacaaagg  agaaccgag  2280
tcctgaagc  aggagctcc  tttactgtc  ttctcaaaa  agggtcatt  gacacagcc  2340
agtcgtcaa  ggccccttt  cttgtacgg  gcccccccg  ccccggcag  ttgacactg  2400
tttcagtgt  tatttgggg  gaaagcaat  ttgtcttgg  attttgtat  ttgtaggaa  2460
ccttagaga  tgtggttcc  tctgatggg  agaaagggc  aattatttt  atattttgt  2520
tttcacctt  ataaacatg  atcctcagg  gtgaagaac  gtttgcata  ttttctgaa  2580
ttcaggcac  ttgtgctat  tgaggaccc  tatatttaa  ctttttgtg  agtaagaaa  2640
tgtaaagcc  attccagtg  tggacgaaa  aggtctcgt  tttaggtca  ggtgtctcc  2700
ttctctatc  gtgcaggga  atgcagttt  tgtggggca  ggtaggacc  tgcatcatt  2760
ggagcccag  aggaggccg  ctggccagg  ctcaccgcc  cagtatgca  tccagctcc  2820
cgtcatccc  tcacaatgg  tagtagcaa  gtctgggtt  gaacgccag  cgtggttat  2880
ttattgagg  tgcctttgc  catgtggcc  tgctgtgtt  ggactgtgc  ccagggccc  2940
gacttgaag  tagagctgg  agaagagct  ctggcatcc  tggtgcgat  ctgccgcca  3000
ccagtttct  cattggaag  caagggaat  agaagactg  tgtgtatgt  tatttgtga  3060
cttggttgt  atctggtat  ccataggat  tcagacaat  tcactggtt  aagtaaagc  3120
tatttttca  at  3132



<210> 8869
<211> 360
<212> PRT
<213> Rattus norvegicus
<308> P70618
<400> 8869

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
  1               5                  10                  15
Val Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
             20                  25                  30
Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly His 
         35                  40                  45
Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
     50                  55                  60
Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
 65                  70                  75                  80
Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                 85                  90                  95
Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
             100                105                110
Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
         115                120                125
Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
     130                135                140
Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
 145                150                155                160
Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                 165                170                175
Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
             180                185                190
Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
         195                200                205
Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
     210                215                220
Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
 225                230                235                240
Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                 245                250                255
Asn Tyr Ile Gln Ser Leu Ala Gln Met Pro Lys Met Asn Phe Ala Asn 
             260                265                270
Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
         275                280                285
Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
     290                295                300
His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
 305                310                315                320
Glu Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Phe Leu Ile Asp Glu 
                 325                330                335
Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
             340                345                350
Leu Asp Gln Glu Glu Met Glu Ser 
         355                360



<210> 8870
<211> 3757
<212> DNA
<213> Homo sapiens
<308> L35263
<400> 8870

ggaaccgcg  ccactggag  cttagcggg  gcagcagct  gaacgggag  actgcgacg  60
agcccggag  cggccttgt  ggggcgaag  tgcagggag  tcgcggcgg  cgcagtctt  120
agcgccgga  cgcgtccct  cccttagcg  ggcttgccc  agtcgcagg  gcacatcca  180
ccgctgcgg  tgacagcag  cgcgcgcgc  ggagtctgc  gggtcgcgg  agccgcacc  240
gcgcgggcg  ccagcgcaa  gtccccgcc  ggctgggcg  gcagcaagg  ccggggaga  300
ggtgcgggt  caggcgggg  ccccacagg  ccaccttct  gcccggcgg  tgccgctgg  360
aaatgtctc  ggagaggcc  acgttctac  ggcaggagc  gaacaagac  atctgggag  420
tgcccgagc  ttaccagaa  ctgtctcca  tgggctctg  cgcctatgg  tctgtgtgt  480
ctgcttttg  cacaaaaac  gggttacgt  tggcagtga  gaagctctc  agaccattt  540
agtccatca  tcatgcgaa  agaacctac  gagaactgc  gttacttaa  catatgaaa  600
atgaaaatg  gattggtct  ttggacgtt  ttacacctg  aaggtctct  gaggaattc  660
atgatgtgt  tctggtgac  catctcatg  gggcagatc  gaacaacat  gtgaaatgt  720
agaagctta  agatgacca  gttcagttc  ttatctacc  aattctccg  ggtctaaag  780
atatacatt  agctgacat  attcacagg  acctaaaac  tagtaatct  gctgtgaat  840
aagactgtg  gctgaagat  ctggatttt  gactggctc  gcacacaga  gatgaaatg  900
caggctacg  ggccactag  tggtacagg  ctcctgaga  catgctgaa  tggatgcat  960
acaaccaga  agttgatat  tggtcagtg  gatgcataa  ggccgagct  ttgactgga  1020
gaacattgt  tcctggtac  gaccatatt  accagcttc  gcagattat  cgtctgaca  1080
gaacacccc  cgcttatct  attaacagg  tgccaagcc  tgaggcaag  aactatatt  1140
agtctttga  tcagatgcc  aagatgaac  ttgcgaatg  atttattgg  gccaatccc  1200
tggctgtcg  cttgctgga  aagatgctt  tattggact  agataagag  attacagcg  1260
cccaagccc  tgcacatgc  tactttgct  agtaccacg  tcctgatga  gaaccagtg  1320
ccgatcctt  tgatcagtc  tttgaaagc  gggacctcc  tatagatga  tggaaaagc  1380
tgacctatg  tgaagtcat  agctttgtg  caccacccc  tgaccaaga  gagatggag  1440
cctgagcac  tggtttctg  tctgttgat  ccacttcac  gtgagggga  ggccttttc  1500
cgggaactc  ccaaatatt  ttcaagtgc  tcttgttgc  gagatttcc  ccatggtgg  1560
agggggtgt  cgtgcgtgt  cgtgcgtgt  agtgtgtgt  catgtgtgt  tctgtcttt  1620
tgggagggt  agacaatat  aacaaacta  gatcacagt  actttacag  aggttgtgg  1680
tgctccagg  cagcctcca  cttgctctt  tttctgaga  ttggctcag  cagacaaga  1740
ctgctgtcc  tttaggaat  tgttcaatg  aaagtaaaa  aatatgaat  gtccccaat  1800
ccggtcatg  ttttgccac  ttggcttct  ctgtgaccc  accttgacg  tggggcgta  1860
acttgacaa  atcccacag  ggcacggag  gaaggccca  accttctgg  tgcttcaga  1920
ctgacaccg  ccctcagtg  tacgtacag  caaaaagga  caactggct  ctgtgcact  1980
gcctgtgat  aacttgctt  gtatggttc  cagatcttg  cagtatatt  gaaactgta  2040
atatgtttg  gccttaaaa  gagagaaga  agtgtagat  gttaaaaga  tgcagctgc  2100
gaagttctg  gccgggcaa  tcgagaggg  tgttggaca  ctgcttgtg  gcccggagt  2160
atcaggcag  cttcatagg  ggtcatgtg  gcatgtgag  acatgcgta  atgtgcgtc  2220
ctctttctc  ctcaccccc  ggtgttgcc  tttctctgc  tacccttca  ctttggtgc  2280
gaggtttct  gaatatctg  cccagtagt  agaagcagg  tcttgatgt  atgtacttc  2340
tgtgtactc  ttatttcta  cagagtgag  atgtgtttt  cacgtcttg  tatttgagc  2400
tgcacagct  cttgtcctg  tctcttcag  aggccctgg  gtcaggcag  tttgccagt  2460
aagacttct  gggtagttt  gatcccatg  cacctcagc  gatattatg  caagtgata  2520
cacctctct  cagccccta  tgctattct  tgttgaaca  aattgatac  tcaggtgct  2580
ttgatgtga  aatcatgaa  agaggaaca  gtggatgta  agcattttt  ttcatgcca  2640
ctgttttca  ccaactatt  ttgaggaat  atcatggga  aagaccagg  cttttccca  2700
gaatatccc  aacttcgga  acaagttat  ctcttcact  ccaataact  atgctaaga  2760
atgctgaaa  tcaaagtaa  aaattaaag  ccataaggc  agaaactcc  tttgctgtc  2820
ttctctaaa  atgattact  taaaataaa  aagtaacaa  gtgtctttt  cactcctat  2880
gaaaagggt  ttcttggca  cttaacatt  acttcttgg  ttggggaga  ataaatttt  2940
tttcagaat  ttgtatatt  taggaatcc  tttgagaat  tgattcctt  tgatgggga  3000
aaagggcaa  ttattttaa  attttgtat  ttcaacttt  taaagataa  atatcctca  3060
gggtggaga  gtgtcgttt  cataacttg  tgaatttca  gcattttgt  ctacatgag  3120
actcatata  ttaagcctt  tgtgtaata  gaaagtata  agtcacttc  agtgttggc  3180
gtgtgacag  atcttgtat  tgggccaag  tgtttccat  tctcaatca  tgcagtgat  3240
catgtactc  agagggaca  ggtggaccc  ctgagtcaa  tggagcaag  aggaaggag  3300
cagactgat  gcgattccc  ctcacccgg  actctcccc  tttcaagga  agtgaacct  3360
taaagtaaa  gcctcatct  ctttattgc  gttcaaatc  tcaccatcc  cagcaagat  3420
aattttatc  gccatgttt  gttgtaaat  ctcgtgtga  ttcctacag  aatactgct  3480
tgaatattt  gtaataaag  tctttgcac  tgtgaccac  tacgtgtta  gaggctgca  3540
gctctggaa  cctggactc  aagctggag  tcttggaag  gctcttcgg  ttctgagca  3600
aatgctccc  tctcctgat  tctctgaac  gaaaacaaa  gagagaatg  gggaaattg  3660
tattttatt  gtattcatg  acttggctg  aatcagtta  gccgtatag  atgtcagac  3720
ataccactg  ttaaaataa  gcctatttt  caaattt  3757



<210> 8871
<211> 360
<212> PRT
<213> Homo sapiens
<308> Q16539
<400> 8871

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
  1               5                  10                  15
Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
             20                  25                  30
Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
         35                  40                  45
Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
     50                  55                  60
Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
 65                  70                  75                  80
Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                 85                  90                  95
Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
             100                105                110
Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
         115                120                125
Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
     130                135                140
Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
 145                150                155                160
Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                 165                170                175
Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
             180                185                190
Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
         195                200                205
Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
     210                215                220
Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
 225                230                235                240
Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                 245                250                255
Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
             260                265                270
Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
         275                280                285
Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
     290                295                300
His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
 305                310                315                320
Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                 325                330                335
Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
             340                345                350
Leu Asp Gln Glu Glu Met Glu Ser 
         355                360



<210> 8872
<211> 3132
<212> DNA
<213> Rattus norvegicus
<308> U73142
<400> 8872

gccgctgga  aatgtcgca  gaaaggccc  cgttctacc  gcaggagct  aacaagacc  60
tctgggagg  gcccgagcg  taccagaac  tgtccccgg  gggctcggg  gcctacggc  120
cggtgtgtg  tgcttttga  acaaagacg  gacatcgtg  ggcagtgaa  aagctgtcg  180
gaccgtttc  gtccatcat  cacgccaaa  ggacctaca  ggagctgcg  ctgctgaag  240
acatgaagc  cgagaatgt  attggtctg  tggatgtgt  tacacctgc  aggtccctg  300
aagaattca  cgatgtgta  ctggtgacc  atctcatgg  ggcagacct  aacaacatc  360
tgaagtgtc  gaagcttac  gatgaccac  ttcagtttc  tatctacca  atcctgcga  420
ggctgaagt  tatacactc  gctgacata  tccacaggg  cctaaagcc  agcaacctc  480
ctgtgaatg  agactgtga  ctgaagatt  tggattttg  gctggctcg  cacactgat  540
acgaaatga  cggctacgt  gctacccgg  ggtacagag  ccccgagat  atgctgaat  600
ggatgcact  caaccagac  gtggatatt  ggtccgtgg  ctgcatcat  gctgagctg  660
tgaccggaa  aacgttgtt  cctggtaca  accatattg  tcagttgaa  ctcatttta  720
gactcgttg  aaccccagg  gctgagctt  tgaagaaaa  ctcctcaga  tctgcaaga  780
actacattc  gtctctggc  cagatgccg  agatgaact  cgcaaatgt  tttattggt  840
ccaatcccc  ggctgtcga  ctgctggaa  agatgctgg  tttggactc  gataagagg  900
tcacagcag  ccaagctct  gcgcatgcc  actttgctc  gtaccacga  cctgatgat  960
agccagtgg  tgaacctta  gaccagtcc  ttgaaagca  ggacttcct  atagacgaa  1020
ggaagagcc  gacctacga  gaagtcatt  gctttgtgc  accgcccct  gaccaagaa  1080
aaatggagt  ctgagcacc  tgcttctgt  ctgtccatc  cacttcact  tgaggggaa  1140
gcctgttca  gggaactct  caaatacca  tcaagtgcc  cttgttgaa  gattccttc  1200
tggtggaag  gggtgcatg  atgtgcgta  tgtttgtgt  tgtctgtct  tctgtccgt  1260
tgtccatgt  tctttgtgg  agtcattgt  atggcagtg  cttcatgag  ggtagatgc  1320
ccttggcag  ctgcctgct  tctcagagt  cgggcaggc  gatgggaac  gccgtctcc  1380
tagggatgt  tgtgtgtat  ttaagtgca  agtaagaat  ttaaaatat  cctgttcct  1440
gttaccttg  cacttcggc  tctcctgtg  ccctgcctt  accatatca  agtgacaga  1500
agaggctgc  tcaggtctg  ggctatccc  cagccatgc  taaagccca  gagaaccaa  1560
tggctcctg  gctctagcc  gtgatcggc  tgctcatgt  ctcagaacc  gtcagtctg  1620
ttgtgcctt  aaaggagag  agggcgcgt  gtggtagtt  cagaatctc  gttgctggc  1680
ttctgagcc  ggcaaggca  agggctgtt  gatggccag  ggggagctg  acaaaacaa  1740
gcagccttc  aggaggcca  gggtgcatg  ttgcatgag  gtatgtgca  ccgccctcc  1800
tcacctcca  gagcaagct  ttttctatg  ttacctaag  tcacctcag  gcagaggtc  1860
ccagtgcca  gcacaggct  ctgccatca  tagcttcct  tgtcatctt  acgtcatgc  1920
ggtgtttgc  tgctgtgct  tggagcttg  cctgtcttc  ggaagccct  ggccgggcg  1980
gtgaagact  cccagcagt  ctatccacg  acctcagct  aggccacgg  cacactgct  2040
cttcctcac  ccagctacg  tgtgttgaa  acaactgat  ctccaggtg  ttgtggtgc  2100
ggaaacggg  cgaacagag  acctgaacc  ttgccatct  acatcaccg  cacaggaga  2160
cagtcctct  ctctcctct  ctctcctct  ctaggacag  ccccggctc  ggaatcatg  2220
tcttctcac  catggtagc  agctaagaa  gctgcaaac  gaacaaagg  agaaccgag  2280
tcctgaagc  aggagctcc  tttactgtc  ttctcaaaa  agggtcatt  gacacagcc  2340
agtcgtcaa  ggccccttt  cttgtacgg  gcccccccg  ccccggcag  ttgacactg  2400
tttcagtgt  tatttgggg  gaaagcaat  ttgtcttgg  attttgtat  ttgtaggaa  2460
ccttagaga  tgtggttcc  tctgatggg  agaaagggc  aattatttt  atattttgt  2520
tttcacctt  ataaacatg  atcctcagg  gtgaagaac  gtttgcata  ttttctgaa  2580
ttcaggcac  ttgtgctat  tgaggaccc  tatatttaa  ctttttgtg  agtaagaaa  2640
tgtaaagcc  attccagtg  tggacgaaa  aggtctcgt  tttaggtca  ggtgtctcc  2700
ttctctatc  gtgcaggga  atgcagttt  tgtggggca  ggtaggacc  tgcatcatt  2760
ggagcccag  aggaggccg  ctggccagg  ctcaccgcc  cagtatgca  tccagctcc  2820
cgtcatccc  tcacaatgg  tagtagcaa  gtctgggtt  gaacgccag  cgtggttat  2880
ttattgagg  tgcctttgc  catgtggcc  tgctgtgtt  ggactgtgc  ccagggccc  2940
gacttgaag  tagagctgg  agaagagct  ctggcatcc  tggtgcgat  ctgccgcca  3000
ccagtttct  cattggaag  caagggaat  agaagactg  tgtgtatgt  tatttgtga  3060
cttggttgt  atctggtat  ccataggat  tcagacaat  tcactggtt  aagtaaagc  3120
tatttttca  at  3132



<210> 8873
<211> 360
<212> PRT
<213> Rattus norvegicus
<308> P70618
<400> 8873

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
  1               5                  10                  15
Val Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
             20                  25                  30
Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly His 
         35                  40                  45
Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
     50                  55                  60
Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
 65                  70                  75                  80
Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                 85                  90                  95
Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
             100                105                110
Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
         115                120                125
Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
     130                135                140
Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
 145                150                155                160
Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                 165                170                175
Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
             180                185                190
Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
         195                200                205
Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
     210                215                220
Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
 225                230                235                240
Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                 245                250                255
Asn Tyr Ile Gln Ser Leu Ala Gln Met Pro Lys Met Asn Phe Ala Asn 
             260                265                270
Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
         275                280                285
Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
     290                295                300
His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
 305                310                315                320
Glu Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Phe Leu Ile Asp Glu 
                 325                330                335
Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
             340                345                350
Leu Asp Gln Glu Glu Met Glu Ser 
         355                360



<210> 8874
<211> 3757
<212> DNA
<213> Homo sapiens
<308> L35263
<400> 8874

ggaaccgcg  ccactggag  cttagcggg  gcagcagct  gaacgggag  actgcgacg  60
agcccggag  cggccttgt  ggggcgaag  tgcagggag  tcgcggcgg  cgcagtctt  120
agcgccgga  cgcgtccct  cccttagcg  ggcttgccc  agtcgcagg  gcacatcca  180
ccgctgcgg  tgacagcag  cgcgcgcgc  ggagtctgc  gggtcgcgg  agccgcacc  240
gcgcgggcg  ccagcgcaa  gtccccgcc  ggctgggcg  gcagcaagg  ccggggaga  300
ggtgcgggt  caggcgggg  ccccacagg  ccaccttct  gcccggcgg  tgccgctgg  360
aaatgtctc  ggagaggcc  acgttctac  ggcaggagc  gaacaagac  atctgggag  420
tgcccgagc  ttaccagaa  ctgtctcca  tgggctctg  cgcctatgg  tctgtgtgt  480
ctgcttttg  cacaaaaac  gggttacgt  tggcagtga  gaagctctc  agaccattt  540
agtccatca  tcatgcgaa  agaacctac  gagaactgc  gttacttaa  catatgaaa  600
atgaaaatg  gattggtct  ttggacgtt  ttacacctg  aaggtctct  gaggaattc  660
atgatgtgt  tctggtgac  catctcatg  gggcagatc  gaacaacat  gtgaaatgt  720
agaagctta  agatgacca  gttcagttc  ttatctacc  aattctccg  ggtctaaag  780
atatacatt  agctgacat  attcacagg  acctaaaac  tagtaatct  gctgtgaat  840
aagactgtg  gctgaagat  ctggatttt  gactggctc  gcacacaga  gatgaaatg  900
caggctacg  ggccactag  tggtacagg  ctcctgaga  catgctgaa  tggatgcat  960
acaaccaga  agttgatat  tggtcagtg  gatgcataa  ggccgagct  ttgactgga  1020
gaacattgt  tcctggtac  gaccatatt  accagcttc  gcagattat  cgtctgaca  1080
gaacacccc  cgcttatct  attaacagg  tgccaagcc  tgaggcaag  aactatatt  1140
agtctttga  tcagatgcc  aagatgaac  ttgcgaatg  atttattgg  gccaatccc  1200
tggctgtcg  cttgctgga  aagatgctt  tattggact  agataagag  attacagcg  1260
cccaagccc  tgcacatgc  tactttgct  agtaccacg  tcctgatga  gaaccagtg  1320
ccgatcctt  tgatcagtc  tttgaaagc  gggacctcc  tatagatga  tggaaaagc  1380
tgacctatg  tgaagtcat  agctttgtg  caccacccc  tgaccaaga  gagatggag  1440
cctgagcac  tggtttctg  tctgttgat  ccacttcac  gtgagggga  ggccttttc  1500
cgggaactc  ccaaatatt  ttcaagtgc  tcttgttgc  gagatttcc  ccatggtgg  1560
agggggtgt  cgtgcgtgt  cgtgcgtgt  agtgtgtgt  catgtgtgt  tctgtcttt  1620
tgggagggt  agacaatat  aacaaacta  gatcacagt  actttacag  aggttgtgg  1680
tgctccagg  cagcctcca  cttgctctt  tttctgaga  ttggctcag  cagacaaga  1740
ctgctgtcc  tttaggaat  tgttcaatg  aaagtaaaa  aatatgaat  gtccccaat  1800
ccggtcatg  ttttgccac  ttggcttct  ctgtgaccc  accttgacg  tggggcgta  1860
acttgacaa  atcccacag  ggcacggag  gaaggccca  accttctgg  tgcttcaga  1920
ctgacaccg  ccctcagtg  tacgtacag  caaaaagga  caactggct  ctgtgcact  1980
gcctgtgat  aacttgctt  gtatggttc  cagatcttg  cagtatatt  gaaactgta  2040
atatgtttg  gccttaaaa  gagagaaga  agtgtagat  gttaaaaga  tgcagctgc  2100
gaagttctg  gccgggcaa  tcgagaggg  tgttggaca  ctgcttgtg  gcccggagt  2160
atcaggcag  cttcatagg  ggtcatgtg  gcatgtgag  acatgcgta  atgtgcgtc  2220
ctctttctc  ctcaccccc  ggtgttgcc  tttctctgc  tacccttca  ctttggtgc  2280
gaggtttct  gaatatctg  cccagtagt  agaagcagg  tcttgatgt  atgtacttc  2340
tgtgtactc  ttatttcta  cagagtgag  atgtgtttt  cacgtcttg  tatttgagc  2400
tgcacagct  cttgtcctg  tctcttcag  aggccctgg  gtcaggcag  tttgccagt  2460
aagacttct  gggtagttt  gatcccatg  cacctcagc  gatattatg  caagtgata  2520
cacctctct  cagccccta  tgctattct  tgttgaaca  aattgatac  tcaggtgct  2580
ttgatgtga  aatcatgaa  agaggaaca  gtggatgta  agcattttt  ttcatgcca  2640
ctgttttca  ccaactatt  ttgaggaat  atcatggga  aagaccagg  cttttccca  2700
gaatatccc  aacttcgga  acaagttat  ctcttcact  ccaataact  atgctaaga  2760
atgctgaaa  tcaaagtaa  aaattaaag  ccataaggc  agaaactcc  tttgctgtc  2820
ttctctaaa  atgattact  taaaataaa  aagtaacaa  gtgtctttt  cactcctat  2880
gaaaagggt  ttcttggca  cttaacatt  acttcttgg  ttggggaga  ataaatttt  2940
tttcagaat  ttgtatatt  taggaatcc  tttgagaat  tgattcctt  tgatgggga  3000
aaagggcaa  ttattttaa  attttgtat  ttcaacttt  taaagataa  atatcctca  3060
gggtggaga  gtgtcgttt  cataacttg  tgaatttca  gcattttgt  ctacatgag  3120
actcatata  ttaagcctt  tgtgtaata  gaaagtata  agtcacttc  agtgttggc  3180
gtgtgacag  atcttgtat  tgggccaag  tgtttccat  tctcaatca  tgcagtgat  3240
catgtactc  agagggaca  ggtggaccc  ctgagtcaa  tggagcaag  aggaaggag  3300
cagactgat  gcgattccc  ctcacccgg  actctcccc  tttcaagga  agtgaacct  3360
taaagtaaa  gcctcatct  ctttattgc  gttcaaatc  tcaccatcc  cagcaagat  3420
aattttatc  gccatgttt  gttgtaaat  ctcgtgtga  ttcctacag  aatactgct  3480
tgaatattt  gtaataaag  tctttgcac  tgtgaccac  tacgtgtta  gaggctgca  3540
gctctggaa  cctggactc  aagctggag  tcttggaag  gctcttcgg  ttctgagca  3600
aatgctccc  tctcctgat  tctctgaac  gaaaacaaa  gagagaatg  gggaaattg  3660
tattttatt  gtattcatg  acttggctg  aatcagtta  gccgtatag  atgtcagac  3720
ataccactg  ttaaaataa  gcctatttt  caaattt  3757



<210> 8875
<211> 360
<212> PRT
<213> Homo sapiens
<308> Q16539
<400> 8875

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
  1               5                  10                  15
Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
             20                  25                  30
Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
         35                  40                  45
Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
     50                  55                  60
Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
 65                  70                  75                  80
Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                 85                  90                  95
Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
             100                105                110
Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
         115                120                125
Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
     130                135                140
Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
 145                150                155                160
Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                 165                170                175
Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
             180                185                190
Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
         195                200                205
Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
     210                215                220
Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
 225                230                235                240
Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                 245                250                255
Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
             260                265                270
Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
         275                280                285
Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
     290                295                300
His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
 305                310                315                320
Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                 325                330                335
Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
             340                345                350
Leu Asp Gln Glu Glu Met Glu Ser 
         355                360



<210> 8876
<211> 1428
<212> DNA
<213> Rattus norvegicus
<308> U73174
<400> 8876

ctgtttctg  tacttgctc  ttgtttcaa  ctgccttgg  gagtttctc  cagtaccgt  60
tgcttcttg  taacttccg  tttaagctt  agtcgttct  tagtctctt  agttttcac  120
ctgagcctc  acactggac  actgaaatc  tgtagtgaa  gttggatgt  tcccaaaaa  180
gtaatgtgg  acacagccg  gcactcgga  ttcatacat  atcacgtgg  ttacggctt  240
caaaactgc  agagtaaat  caattggca  gtcatcaag  agaagcggg  tgcttacgt  300
agccgcctg  acaacatct  ccaaaacaa  ttaaccaag  cccacatcg  agtcatcca  360
ggctacgca  catttcgag  tggtcccca  cccacagcg  aagtcaacg  gaagaagtt  420
actgctccg  acatcctga  cgccacggg  ggtgtgccc  cggttcctc  tgagaacca  480
atcccaggt  ccagcctgg  gataaccag  gatgggttc  ttcagctgg  agacttgcc  540
agccgcagc  ttattgtgg  tgccggtta  attgccgtg  agattgcgg  catcctctc  600
gccctgggc  ccaagacgt  tcttatgat  aggcatgat  aggtgctta  aagctttga  660
tcactcatc  gttccaact  caccgagga  ctggagaac  ctggcggtg  tgaggttct  720
acagttaag  agttctcac  ggttaagga  gtaaagaag  cctcatcgg  cttggaact  780
catgtggtt  ctgcacttc  cggtaggaa  cccaccgtg  ccacgattc  agatgtcga  840
tgcctgctc  gggccattg  acgggaccc  aactctaag  gcctgaatc  aaataaact  900
gggatacag  ctgatgaca  aggccatat  ctagtggac  agttccaga  taccaatgt  960
aaaggcgtc  atgccgtgg  cgatgtctg  gggaaagca  ttctcaccc  agttgcgat  1020
gctgctggc  ggaaactcg  ccatagact  tttgagggc  aagaagatt  caggttgga  1080
tatgacaac  tccctaccg  ggtcttcag  cacccgcct  tcgggacag  ggggctcac  1140
gaagatgaa  ccgtccata  gtatggcaa  gacaatgtg  aaatctact  gaccgcctt  1200
accccgatg  atcacgctg  gaccacgag  aagacgaaa  gcgtgatga  gatggtttg  1260
gccaacaaa  aggagaagg  ggttggcat  catatgcag  ggattggct  cgatgagat  1320
cttcagggc  tcgctgtag  agtgaaaat  ggggccacc  aggccgact  cgacaatag  1380
gtcgccatt  atcctacct  ttcagagga  ctggtcaca  ttcgttga  1428



<210> 8877
<211> 420
<212> PRT
<213> Rattus norvegicus
<308> AAB18132
<400> 8877

Met Cys Pro Lys Lys Val Met Trp Asn Thr Ala Val His Ser Glu Phe 
  1               5                  10                  15
Ile His Asp His Val Asp Tyr Gly Phe Gln Asn Cys Lys Ser Lys Phe 
             20                  25                  30
Asn Trp His Val Ile Lys Glu Lys Arg Asp Ala Tyr Val Ser Arg Leu 
         35                  40                  45
Asn Asn Ile Tyr Gln Asn Asn Leu Thr Lys Ser His Ile Glu Val Ile 
     50                  55                  60
His Gly Tyr Ala Thr Phe Arg Asp Gly Pro Gln Pro Thr Ala Glu Val 
 65                  70                  75                  80
Asn Gly Lys Lys Phe Thr Ala Pro His Ile Leu Ile Ala Thr Gly Gly 
                 85                  90                  95
Val Pro Thr Val Pro His Glu Asn Gln Ile Pro Gly Ala Ser Leu Gly 
             100                105                110
Ile Thr Ser Asp Gly Phe Phe Gln Leu Glu Asp Leu Pro Ser Arg Ser 
         115                120                125
Val Ile Val Gly Ala Gly Tyr Ile Ala Val Glu Ile Ala Gly Ile Leu 
     130                135                140
Ser Ala Leu Gly Ser Lys Thr Ser Leu Met Ile Arg His Asp Lys Val 
 145                150                155                160
Leu Arg Ser Phe Asp Ser Leu Ile Ser Ser Asn Cys Thr Glu Glu Leu 
                 165                170                175
Glu Asn Ala Gly Gly Val Glu Val Leu Thr Val Lys Lys Phe Ser Gln 
             180                185                190
Val Lys Glu Val Lys Lys Thr Ser Ser Gly Leu Glu Leu His Val Val 
         195                200                205
Thr Ala Leu Pro Gly Arg Lys Pro Thr Val Thr Thr Ile Pro Asp Val 
     210                215                220
Asp Cys Leu Leu Trp Ala Ile Gly Arg Asp Pro Asn Ser Lys Gly Leu 
 225                230                235                240
Asn Leu Asn Lys Leu Gly Ile Gln Thr Asp Asp Lys Gly His Ile Leu 
                 245                250                255
Val Asp Glu Phe Gln Asn Thr Asn Val Lys Gly Val Tyr Ala Val Gly 
             260                265                270
Asp Val Cys Gly Lys Ala Leu Leu Thr Pro Val Ala Ile Ala Ala Gly 
         275                280                285
Arg Lys Leu Ala His Arg Leu Phe Glu Gly Lys Glu Asp Ser Arg Leu 
     290                295                300
Asp Tyr Asp Asn Ile Pro Thr Val Val Phe Ser His Pro Pro Ile Gly 
 305                310                315                320
Thr Val Gly Leu Thr Glu Asp Glu Ala Val His Lys Tyr Gly Lys Asp 
                 325                330                335
Asn Val Lys Ile Tyr Ser Thr Ala Phe Thr Pro Met Tyr His Ala Val 
             340                345                350
Thr Thr Arg Lys Thr Lys Cys Val Met Lys Met Val Cys Ala Asn Lys 
         355                360                365
Glu Glu Lys Val Val Gly Ile His Met Gln Gly Ile Gly Cys Asp Glu 
     370                375                380
Met Leu Gln Gly Phe Ala Val Ala Val Lys Met Gly Ala Thr Lys Ala 
 385                390                395                400
Asp Phe Asp Asn Arg Val Ala Ile His Pro Thr Ser Ser Glu Glu Leu 
                 405                410                415
Val Thr Leu Arg 
             420



<210> 8878
<211> 522
<212> PRT
<213> Homo sapiens
<308> 1GRT
<400> 8878

Met Ala Leu Leu Pro Arg Ala Leu Ser Ala Gly Ala Gly Pro Ser Trp 
  1               5                  10                  15
Arg Arg Ala Ala Arg Ala Phe Arg Gly Phe Leu Leu Leu Leu Pro Glu 
             20                  25                  30
Pro Ala Ala Leu Thr Arg Ala Leu Ser Arg Ala Met Ala Cys Arg Gln 
         35                  40                  45
Glu Pro Gln Pro Gln Gly Pro Pro Pro Ala Ala Gly Ala Val Ala Ser 
     50                  55                  60
Tyr Asp Tyr Leu Val Ile Gly Gly Gly Ser Gly Gly Leu Ala Ser Ala 
 65                  70                  75                  80
Arg Arg Ala Ala Glu Leu Gly Ala Arg Ala Ala Val Val Glu Ser His 
                 85                  90                  95
Lys Leu Gly Gly Thr Cys Val Asn Val Gly Cys Val Pro Lys Lys Val 
             100                105                110
Met Trp Asn Thr Ala Val His Ser Glu Phe Met His Asp His Ala Asp 
         115                120                125
Tyr Gly Phe Pro Ser Cys Glu Gly Lys Phe Asn Trp Arg Val Ile Lys 
     130                135                140
Glu Lys Arg Asp Ala Tyr Val Ser Arg Leu Asn Ala Ile Tyr Gln Asn 
 145                150                155                160
Asn Leu Thr Lys Ser His Ile Glu Ile Ile Arg Gly His Ala Ala Phe 
                 165                170                175
Thr Ser Asp Pro Lys Pro Thr Ile Glu Val Ser Gly Lys Lys Tyr Thr 
             180                185                190
Ala Pro His Ile Leu Ile Ala Thr Gly Gly Met Pro Ser Thr Pro His 
         195                200                205
Glu Ser Gln Ile Pro Gly Ala Ser Leu Gly Ile Thr Ser Asp Gly Phe 
     210                215                220
Phe Gln Leu Glu Glu Leu Pro Gly Arg Ser Val Ile Val Gly Ala Gly 
 225                230                235                240
Tyr Ile Ala Val Glu Met Ala Gly Ile Leu Ser Ala Leu Gly Ser Lys 
                 245                250                255
Thr Ser Leu Met Ile Arg His Asp Lys Val Leu Arg Ser Phe Asp Ser 
             260                265                270
Met Ile Ser Thr Asn Cys Thr Glu Glu Leu Glu Asn Ala Gly Val Glu 
         275                280                285
Val Leu Lys Phe Ser Gln Val Lys Glu Val Lys Lys Thr Leu Ser Gly 
     290                295                300
Leu Glu Val Ser Met Val Thr Ala Val Pro Gly Arg Leu Pro Val Met 
 305                310                315                320
Thr Met Ile Pro Asp Val Asp Cys Leu Leu Trp Ala Ile Gly Arg Val 
                 325                330                335
Pro Asn Thr Lys Asp Leu Ser Leu Asn Lys Leu Gly Ile Gln Thr Asp 
             340                345                350
Asp Lys Gly His Ile Ile Val Asp Glu Phe Gln Asn Thr Asn Val Lys 
         355                360                365
Gly Ile Tyr Ala Val Gly Asp Val Cys Gly Lys Ala Leu Leu Thr Pro 
     370                375                380
Val Ala Ile Ala Ala Gly Arg Lys Leu Ala His Arg Leu Phe Glu Tyr 
 385                390                395                400
Lys Glu Asp Ser Lys Leu Asp Tyr Asn Asn Ile Pro Thr Val Val Phe 
                 405                410                415
Ser His Pro Pro Ile Gly Thr Val Gly Leu Thr Glu Asp Glu Ala Ile 
             420                425                430
His Lys Tyr Gly Ile Glu Asn Val Lys Thr Tyr Ser Thr Ser Phe Thr 
         435                440                445
Pro Met Tyr His Ala Val Thr Lys Arg Lys Thr Lys Cys Val Met Lys 
     450                455                460
Met Val Cys Ala Asn Lys Glu Glu Lys Val Val Gly Ile His Met Gln 
 465                470                475                480
Gly Leu Gly Cys Asp Glu Met Leu Gln Gly Phe Ala Val Ala Val Lys 
                 485                490                495
Met Gly Ala Thr Lys Ala Asp Phe Asp Asn Thr Val Ala Ile His Pro 
             500                505                510
Thr Ser Ser Glu Glu Leu Val Thr Leu Arg 
         515                520



<210> 8879
<211> 1428
<212> DNA
<213> Rattus norvegicus
<308> U73174
<400> 8879

ctgtttctg  tacttgctc  ttgtttcaa  ctgccttgg  gagtttctc  cagtaccgt  60
tgcttcttg  taacttccg  tttaagctt  agtcgttct  tagtctctt  agttttcac  120
ctgagcctc  acactggac  actgaaatc  tgtagtgaa  gttggatgt  tcccaaaaa  180
gtaatgtgg  acacagccg  gcactcgga  ttcatacat  atcacgtgg  ttacggctt  240
caaaactgc  agagtaaat  caattggca  gtcatcaag  agaagcggg  tgcttacgt  300
agccgcctg  acaacatct  ccaaaacaa  ttaaccaag  cccacatcg  agtcatcca  360
ggctacgca  catttcgag  tggtcccca  cccacagcg  aagtcaacg  gaagaagtt  420
actgctccg  acatcctga  cgccacggg  ggtgtgccc  cggttcctc  tgagaacca  480
atcccaggt  ccagcctgg  gataaccag  gatgggttc  ttcagctgg  agacttgcc  540
agccgcagc  ttattgtgg  tgccggtta  attgccgtg  agattgcgg  catcctctc  600
gccctgggc  ccaagacgt  tcttatgat  aggcatgat  aggtgctta  aagctttga  660
tcactcatc  gttccaact  caccgagga  ctggagaac  ctggcggtg  tgaggttct  720
acagttaag  agttctcac  ggttaagga  gtaaagaag  cctcatcgg  cttggaact  780
catgtggtt  ctgcacttc  cggtaggaa  cccaccgtg  ccacgattc  agatgtcga  840
tgcctgctc  gggccattg  acgggaccc  aactctaag  gcctgaatc  aaataaact  900
gggatacag  ctgatgaca  aggccatat  ctagtggac  agttccaga  taccaatgt  960
aaaggcgtc  atgccgtgg  cgatgtctg  gggaaagca  ttctcaccc  agttgcgat  1020
gctgctggc  ggaaactcg  ccatagact  tttgagggc  aagaagatt  caggttgga  1080
tatgacaac  tccctaccg  ggtcttcag  cacccgcct  tcgggacag  ggggctcac  1140
gaagatgaa  ccgtccata  gtatggcaa  gacaatgtg  aaatctact  gaccgcctt  1200
accccgatg  atcacgctg  gaccacgag  aagacgaaa  gcgtgatga  gatggtttg  1260
gccaacaaa  aggagaagg  ggttggcat  catatgcag  ggattggct  cgatgagat  1320
cttcagggc  tcgctgtag  agtgaaaat  ggggccacc  aggccgact  cgacaatag  1380
gtcgccatt  atcctacct  ttcagagga  ctggtcaca  ttcgttga  1428



<210> 8880
<211> 420
<212> PRT
<213> Rattus norvegicus
<308> AAB18132
<400> 8880

Met Cys Pro Lys Lys Val Met Trp Asn Thr Ala Val His Ser Glu Phe 
  1               5                  10                  15
Ile His Asp His Val Asp Tyr Gly Phe Gln Asn Cys Lys Ser Lys Phe 
             20                  25                  30
Asn Trp His Val Ile Lys Glu Lys Arg Asp Ala Tyr Val Ser Arg Leu 
         35                  40                  45
Asn Asn Ile Tyr Gln Asn Asn Leu Thr Lys Ser His Ile Glu Val Ile 
     50                  55                  60
His Gly Tyr Ala Thr Phe Arg Asp Gly Pro Gln Pro Thr Ala Glu Val 
 65                  70                  75                  80
Asn Gly Lys Lys Phe Thr Ala Pro His Ile Leu Ile Ala Thr Gly Gly 
                 85                  90                  95
Val Pro Thr Val Pro His Glu Asn Gln Ile Pro Gly Ala Ser Leu Gly 
             100                105                110
Ile Thr Ser Asp Gly Phe Phe Gln Leu Glu Asp Leu Pro Ser Arg Ser 
         115                120                125
Val Ile Val Gly Ala Gly Tyr Ile Ala Val Glu Ile Ala Gly Ile Leu 
     130                135                140
Ser Ala Leu Gly Ser Lys Thr Ser Leu Met Ile Arg His Asp Lys Val 
 145                150                155                160
Leu Arg Ser Phe Asp Ser Leu Ile Ser Ser Asn Cys Thr Glu Glu Leu 
                 165                170                175
Glu Asn Ala Gly Gly Val Glu Val Leu Thr Val Lys Lys Phe Ser Gln 
             180                185                190
Val Lys Glu Val Lys Lys Thr Ser Ser Gly Leu Glu Leu His Val Val 
         195                200                205
Thr Ala Leu Pro Gly Arg Lys Pro Thr Val Thr Thr Ile Pro Asp Val 
     210                215                220
Asp Cys Leu Leu Trp Ala Ile Gly Arg Asp Pro Asn Ser Lys Gly Leu 
 225                230                235                240
Asn Leu Asn Lys Leu Gly Ile Gln Thr Asp Asp Lys Gly His Ile Leu 
                 245                250                255
Val Asp Glu Phe Gln Asn Thr Asn Val Lys Gly Val Tyr Ala Val Gly 
             260                265                270
Asp Val Cys Gly Lys Ala Leu Leu Thr Pro Val Ala Ile Ala Ala Gly 
         275                280                285
Arg Lys Leu Ala His Arg Leu Phe Glu Gly Lys Glu Asp Ser Arg Leu 
     290                295                300
Asp Tyr Asp Asn Ile Pro Thr Val Val Phe Ser His Pro Pro Ile Gly 
 305                310                315                320
Thr Val Gly Leu Thr Glu Asp Glu Ala Val His Lys Tyr Gly Lys Asp 
                 325                330                335
Asn Val Lys Ile Tyr Ser Thr Ala Phe Thr Pro Met Tyr His Ala Val 
             340                345                350
Thr Thr Arg Lys Thr Lys Cys Val Met Lys Met Val Cys Ala Asn Lys 
         355                360                365
Glu Glu Lys Val Val Gly Ile His Met Gln Gly Ile Gly Cys Asp Glu 
     370                375                380
Met Leu Gln Gly Phe Ala Val Ala Val Lys Met Gly Ala Thr Lys Ala 
 385                390                395                400
Asp Phe Asp Asn Arg Val Ala Ile His Pro Thr Ser Ser Glu Glu Leu 
                 405                410                415
Val Thr Leu Arg 
             420



<210> 8881
<211> 522
<212> PRT
<213> Homo sapiens
<308> 1GRT
<400> 8881

Met Ala Leu Leu Pro Arg Ala Leu Ser Ala Gly Ala Gly Pro Ser Trp 
  1               5                  10                  15
Arg Arg Ala Ala Arg Ala Phe Arg Gly Phe Leu Leu Leu Leu Pro Glu 
             20                  25                  30
Pro Ala Ala Leu Thr Arg Ala Leu Ser Arg Ala Met Ala Cys Arg Gln 
         35                  40                  45
Glu Pro Gln Pro Gln Gly Pro Pro Pro Ala Ala Gly Ala Val Ala Ser 
     50                  55                  60
Tyr Asp Tyr Leu Val Ile Gly Gly Gly Ser Gly Gly Leu Ala Ser Ala 
 65                  70                  75                  80
Arg Arg Ala Ala Glu Leu Gly Ala Arg Ala Ala Val Val Glu Ser His 
                 85                  90                  95
Lys Leu Gly Gly Thr Cys Val Asn Val Gly Cys Val Pro Lys Lys Val 
             100                105                110
Met Trp Asn Thr Ala Val His Ser Glu Phe Met His Asp His Ala Asp 
         115                120                125
Tyr Gly Phe Pro Ser Cys Glu Gly Lys Phe Asn Trp Arg Val Ile Lys 
     130                135                140
Glu Lys Arg Asp Ala Tyr Val Ser Arg Leu Asn Ala Ile Tyr Gln Asn 
 145                150                155                160
Asn Leu Thr Lys Ser His Ile Glu Ile Ile Arg Gly His Ala Ala Phe 
                 165                170                175
Thr Ser Asp Pro Lys Pro Thr Ile Glu Val Ser Gly Lys Lys Tyr Thr 
             180                185                190
Ala Pro His Ile Leu Ile Ala Thr Gly Gly Met Pro Ser Thr Pro His 
         195                200                205
Glu Ser Gln Ile Pro Gly Ala Ser Leu Gly Ile Thr Ser Asp Gly Phe 
     210                215                220
Phe Gln Leu Glu Glu Leu Pro Gly Arg Ser Val Ile Val Gly Ala Gly 
 225                230                235                240
Tyr Ile Ala Val Glu Met Ala Gly Ile Leu Ser Ala Leu Gly Ser Lys 
                 245                250                255
Thr Ser Leu Met Ile Arg His Asp Lys Val Leu Arg Ser Phe Asp Ser 
             260                265                270
Met Ile Ser Thr Asn Cys Thr Glu Glu Leu Glu Asn Ala Gly Val Glu 
         275                280                285
Val Leu Lys Phe Ser Gln Val Lys Glu Val Lys Lys Thr Leu Ser Gly 
     290                295                300
Leu Glu Val Ser Met Val Thr Ala Val Pro Gly Arg Leu Pro Val Met 
 305                310                315                320
Thr Met Ile Pro Asp Val Asp Cys Leu Leu Trp Ala Ile Gly Arg Val 
                 325                330                335
Pro Asn Thr Lys Asp Leu Ser Leu Asn Lys Leu Gly Ile Gln Thr Asp 
             340                345                350
Asp Lys Gly His Ile Ile Val Asp Glu Phe Gln Asn Thr Asn Val Lys 
         355                360                365
Gly Ile Tyr Ala Val Gly Asp Val Cys Gly Lys Ala Leu Leu Thr Pro 
     370                375                380
Val Ala Ile Ala Ala Gly Arg Lys Leu Ala His Arg Leu Phe Glu Tyr 
 385                390                395                400
Lys Glu Asp Ser Lys Leu Asp Tyr Asn Asn Ile Pro Thr Val Val Phe 
                 405                410                415
Ser His Pro Pro Ile Gly Thr Val Gly Leu Thr Glu Asp Glu Ala Ile 
             420                425                430
His Lys Tyr Gly Ile Glu Asn Val Lys Thr Tyr Ser Thr Ser Phe Thr 
         435                440                445
Pro Met Tyr His Ala Val Thr Lys Arg Lys Thr Lys Cys Val Met Lys 
     450                455                460
Met Val Cys Ala Asn Lys Glu Glu Lys Val Val Gly Ile His Met Gln 
 465                470                475                480
Gly Leu Gly Cys Asp Glu Met Leu Gln Gly Phe Ala Val Ala Val Lys 
                 485                490                495
Met Gly Ala Thr Lys Ala Asp Phe Asp Asn Thr Val Ala Ile His Pro 
             500                505                510
Thr Ser Ser Glu Glu Leu Val Thr Leu Arg 
         515                520



<210> 8882
<211> 1428
<212> DNA
<213> Rattus norvegicus
<308> U73174
<400> 8882

ctgtttctg  tacttgctc  ttgtttcaa  ctgccttgg  gagtttctc  cagtaccgt  60
tgcttcttg  taacttccg  tttaagctt  agtcgttct  tagtctctt  agttttcac  120
ctgagcctc  acactggac  actgaaatc  tgtagtgaa  gttggatgt  tcccaaaaa  180
gtaatgtgg  acacagccg  gcactcgga  ttcatacat  atcacgtgg  ttacggctt  240
caaaactgc  agagtaaat  caattggca  gtcatcaag  agaagcggg  tgcttacgt  300
agccgcctg  acaacatct  ccaaaacaa  ttaaccaag  cccacatcg  agtcatcca  360
ggctacgca  catttcgag  tggtcccca  cccacagcg  aagtcaacg  gaagaagtt  420
actgctccg  acatcctga  cgccacggg  ggtgtgccc  cggttcctc  tgagaacca  480
atcccaggt  ccagcctgg  gataaccag  gatgggttc  ttcagctgg  agacttgcc  540
agccgcagc  ttattgtgg  tgccggtta  attgccgtg  agattgcgg  catcctctc  600
gccctgggc  ccaagacgt  tcttatgat  aggcatgat  aggtgctta  aagctttga  660
tcactcatc  gttccaact  caccgagga  ctggagaac  ctggcggtg  tgaggttct  720
acagttaag  agttctcac  ggttaagga  gtaaagaag  cctcatcgg  cttggaact  780
catgtggtt  ctgcacttc  cggtaggaa  cccaccgtg  ccacgattc  agatgtcga  840
tgcctgctc  gggccattg  acgggaccc  aactctaag  gcctgaatc  aaataaact  900
gggatacag  ctgatgaca  aggccatat  ctagtggac  agttccaga  taccaatgt  960
aaaggcgtc  atgccgtgg  cgatgtctg  gggaaagca  ttctcaccc  agttgcgat  1020
gctgctggc  ggaaactcg  ccatagact  tttgagggc  aagaagatt  caggttgga  1080
tatgacaac  tccctaccg  ggtcttcag  cacccgcct  tcgggacag  ggggctcac  1140
gaagatgaa  ccgtccata  gtatggcaa  gacaatgtg  aaatctact  gaccgcctt  1200
accccgatg  atcacgctg  gaccacgag  aagacgaaa  gcgtgatga  gatggtttg  1260
gccaacaaa  aggagaagg  ggttggcat  catatgcag  ggattggct  cgatgagat  1320
cttcagggc  tcgctgtag  agtgaaaat  ggggccacc  aggccgact  cgacaatag  1380
gtcgccatt  atcctacct  ttcagagga  ctggtcaca  ttcgttga  1428



<210> 8883
<211> 420
<212> PRT
<213> Rattus norvegicus
<308> AAB18132
<400> 8883

Met Cys Pro Lys Lys Val Met Trp Asn Thr Ala Val His Ser Glu Phe 
  1               5                  10                  15
Ile His Asp His Val Asp Tyr Gly Phe Gln Asn Cys Lys Ser Lys Phe 
             20                  25                  30
Asn Trp His Val Ile Lys Glu Lys Arg Asp Ala Tyr Val Ser Arg Leu 
         35                  40                  45
Asn Asn Ile Tyr Gln Asn Asn Leu Thr Lys Ser His Ile Glu Val Ile 
     50                  55                  60
His Gly Tyr Ala Thr Phe Arg Asp Gly Pro Gln Pro Thr Ala Glu Val 
 65                  70                  75                  80
Asn Gly Lys Lys Phe Thr Ala Pro His Ile Leu Ile Ala Thr Gly Gly 
                 85                  90                  95
Val Pro Thr Val Pro His Glu Asn Gln Ile Pro Gly Ala Ser Leu Gly 
             100                105                110
Ile Thr Ser Asp Gly Phe Phe Gln Leu Glu Asp Leu Pro Ser Arg Ser 
         115                120                125
Val Ile Val Gly Ala Gly Tyr Ile Ala Val Glu Ile Ala Gly Ile Leu 
     130                135                140
Ser Ala Leu Gly Ser Lys Thr Ser Leu Met Ile Arg His Asp Lys Val 
 145                150                155                160
Leu Arg Ser Phe Asp Ser Leu Ile Ser Ser Asn Cys Thr Glu Glu Leu 
                 165                170                175
Glu Asn Ala Gly Gly Val Glu Val Leu Thr Val Lys Lys Phe Ser Gln 
             180                185                190
Val Lys Glu Val Lys Lys Thr Ser Ser Gly Leu Glu Leu His Val Val 
         195                200                205
Thr Ala Leu Pro Gly Arg Lys Pro Thr Val Thr Thr Ile Pro Asp Val 
     210                215                220
Asp Cys Leu Leu Trp Ala Ile Gly Arg Asp Pro Asn Ser Lys Gly Leu 
 225                230                235                240
Asn Leu Asn Lys Leu Gly Ile Gln Thr Asp Asp Lys Gly His Ile Leu 
                 245                250                255
Val Asp Glu Phe Gln Asn Thr Asn Val Lys Gly Val Tyr Ala Val Gly 
             260                265                270
Asp Val Cys Gly Lys Ala Leu Leu Thr Pro Val Ala Ile Ala Ala Gly 
         275                280                285
Arg Lys Leu Ala His Arg Leu Phe Glu Gly Lys Glu Asp Ser Arg Leu 
     290                295                300
Asp Tyr Asp Asn Ile Pro Thr Val Val Phe Ser His Pro Pro Ile Gly 
 305                310                315                320
Thr Val Gly Leu Thr Glu Asp Glu Ala Val His Lys Tyr Gly Lys Asp 
                 325                330                335
Asn Val Lys Ile Tyr Ser Thr Ala Phe Thr Pro Met Tyr His Ala Val 
             340                345                350
Thr Thr Arg Lys Thr Lys Cys Val Met Lys Met Val Cys Ala Asn Lys 
         355                360                365
Glu Glu Lys Val Val Gly Ile His Met Gln Gly Ile Gly Cys Asp Glu 
     370                375                380
Met Leu Gln Gly Phe Ala Val Ala Val Lys Met Gly Ala Thr Lys Ala 
 385                390                395                400
Asp Phe Asp Asn Arg Val Ala Ile His Pro Thr Ser Ser Glu Glu Leu 
                 405                410                415
Val Thr Leu Arg 
             420



<210> 8884
<211> 522
<212> PRT
<213> Homo sapiens
<308> 1GRT
<400> 8884

Met Ala Leu Leu Pro Arg Ala Leu Ser Ala Gly Ala Gly Pro Ser Trp 
  1               5                  10                  15
Arg Arg Ala Ala Arg Ala Phe Arg Gly Phe Leu Leu Leu Leu Pro Glu 
             20                  25                  30
Pro Ala Ala Leu Thr Arg Ala Leu Ser Arg Ala Met Ala Cys Arg Gln 
         35                  40                  45
Glu Pro Gln Pro Gln Gly Pro Pro Pro Ala Ala Gly Ala Val Ala Ser 
     50                  55                  60
Tyr Asp Tyr Leu Val Ile Gly Gly Gly Ser Gly Gly Leu Ala Ser Ala 
 65                  70                  75                  80
Arg Arg Ala Ala Glu Leu Gly Ala Arg Ala Ala Val Val Glu Ser His 
                 85                  90                  95
Lys Leu Gly Gly Thr Cys Val Asn Val Gly Cys Val Pro Lys Lys Val 
             100                105                110
Met Trp Asn Thr Ala Val His Ser Glu Phe Met His Asp His Ala Asp 
         115                120                125
Tyr Gly Phe Pro Ser Cys Glu Gly Lys Phe Asn Trp Arg Val Ile Lys 
     130                135                140
Glu Lys Arg Asp Ala Tyr Val Ser Arg Leu Asn Ala Ile Tyr Gln Asn 
 145                150                155                160
Asn Leu Thr Lys Ser His Ile Glu Ile Ile Arg Gly His Ala Ala Phe 
                 165                170                175
Thr Ser Asp Pro Lys Pro Thr Ile Glu Val Ser Gly Lys Lys Tyr Thr 
             180                185                190
Ala Pro His Ile Leu Ile Ala Thr Gly Gly Met Pro Ser Thr Pro His 
         195                200                205
Glu Ser Gln Ile Pro Gly Ala Ser Leu Gly Ile Thr Ser Asp Gly Phe 
     210                215                220
Phe Gln Leu Glu Glu Leu Pro Gly Arg Ser Val Ile Val Gly Ala Gly 
 225                230                235                240
Tyr Ile Ala Val Glu Met Ala Gly Ile Leu Ser Ala Leu Gly Ser Lys 
                 245                250                255
Thr Ser Leu Met Ile Arg His Asp Lys Val Leu Arg Ser Phe Asp Ser 
             260                265                270
Met Ile Ser Thr Asn Cys Thr Glu Glu Leu Glu Asn Ala Gly Val Glu 
         275                280                285
Val Leu Lys Phe Ser Gln Val Lys Glu Val Lys Lys Thr Leu Ser Gly 
     290                295                300
Leu Glu Val Ser Met Val Thr Ala Val Pro Gly Arg Leu Pro Val Met 
 305                310                315                320
Thr Met Ile Pro Asp Val Asp Cys Leu Leu Trp Ala Ile Gly Arg Val 
                 325                330                335
Pro Asn Thr Lys Asp Leu Ser Leu Asn Lys Leu Gly Ile Gln Thr Asp 
             340                345                350
Asp Lys Gly His Ile Ile Val Asp Glu Phe Gln Asn Thr Asn Val Lys 
         355                360                365
Gly Ile Tyr Ala Val Gly Asp Val Cys Gly Lys Ala Leu Leu Thr Pro 
     370                375                380
Val Ala Ile Ala Ala Gly Arg Lys Leu Ala His Arg Leu Phe Glu Tyr 
 385                390                395                400
Lys Glu Asp Ser Lys Leu Asp Tyr Asn Asn Ile Pro Thr Val Val Phe 
                 405                410                415
Ser His Pro Pro Ile Gly Thr Val Gly Leu Thr Glu Asp Glu Ala Ile 
             420                425                430
His Lys Tyr Gly Ile Glu Asn Val Lys Thr Tyr Ser Thr Ser Phe Thr 
         435                440                445
Pro Met Tyr His Ala Val Thr Lys Arg Lys Thr Lys Cys Val Met Lys 
     450                455                460
Met Val Cys Ala Asn Lys Glu Glu Lys Val Val Gly Ile His Met Gln 
 465                470                475                480
Gly Leu Gly Cys Asp Glu Met Leu Gln Gly Phe Ala Val Ala Val Lys 
                 485                490                495
Met Gly Ala Thr Lys Ala Asp Phe Asp Asn Thr Val Ala Ile His Pro 
             500                505                510
Thr Ser Ser Glu Glu Leu Val Thr Leu Arg 
         515                520



<210> 8885
<211> 1281
<212> DNA
<213> Rattus norvegicus
<308> U73525
<400> 8885

cccttgacg  gcaggccgg  tgggctctg  atccctctg  tcacactgc  gggagatgg  60
tcagcggct  ctcctgagg  ggttcctga  ctcagtcat  tccaggaag  ctcctcagg  120
tgtgtgggc  tccctcacc  ctacgagcc  gcagacccc  ccgtacaat  ctggtggtc  180
aactggaac  cccagccct  cccggacat  tcacaccac  agagtctgt  caacaacct  240
taacgtcca  gatggacct  actttcaag  cagagttgt  aacagtgag  caccagttg  300
cgtggactt  catgcacag  ggtgtggcc  ctgcaagat  ctaggacct  ggttagaga  360
gatggtagc  aaacagcac  ggaaggtgg  gatggccaa  gtggacatt  acgatcaca  420
agaccttgc  attgagtac  aggtgtctg  tgtgcctac  gtgctggcc  tcaagaacg  480
ggacgtggt  gacaagttt  tggggatca  ggacgaaga  cagctggaa  ccttcctga  540
gaagctaat  ggctgacaa  cagggaaga  gccagactg  ccttgcctg  tggaaaccc  600
tttggggag  aacctagta  aactcccag  cctcagctg  catccttcg  gccctgccc  660
tgttttgtc  ttgtgggtc  tgcctttgg  cagcagact  ccaaaccta  aagccacca  720
cacttcaga  ccagccctc  gccaggatg  ccaggagag  ggcaatgct  ccgatggtg  780
ggaggaggg  catcctgag  acctcctac  gtgtgcttc  cctgtgcac  tactgtgtg  840
ttcttctag  gcttgttgc  attccccta  atgctagac  aagcctggg  cagcctgta  900
tcaccgccc  ggcaatggc  cagtcctcg  ctctgaggt  ctctgatct  aagcctcag  960
cccacacac  cacatgtgg  tctggtgta  ttcctctcc  gcctctgct  gaaaaggaa  1020
caagaagct  aacaagtga  agtaatgga  aattctctc  tcttttgta  gtctgtaat  1080
aagaacttt  tgtgatccc  tctacctct  gctgtgaag  acagagccc  ccccattcc  1140
tatctctgt  ccttctctt  cttgtcacc  ccctgggtt  gctgggcct  ggttctggt  1200
ccctgagca  gaggaggag  tgtgaacaa  cagaccaat  aaaccaggt  tgcattgcc  1260
caaaaaaaa  aaaaaaaaa  a  1281



<210> 8886
<211> 166
<212> PRT
<213> Rattus norvegicus
<308> P97615
<400> 8886

Met Ala Gln Arg Leu Leu Leu Arg Arg Phe Leu Thr Ser Val Ile Ser 
  1               5                  10                  15
Arg Lys Pro Pro Gln Gly Val Trp Ala Ser Leu Thr Ser Thr Ser Leu 
             20                  25                  30
Gln Thr Pro Pro Tyr Asn Ala Gly Gly Leu Thr Gly Thr Pro Ser Pro 
         35                  40                  45
Ala Arg Thr Phe His Thr Thr Arg Val Cys Ser Thr Thr Phe Asn Val 
     50                  55                  60
Gln Asp Gly Pro Asp Phe Gln Asp Arg Val Val Asn Ser Glu Thr Pro 
 65                  70                  75                  80
Val Val Val Asp Phe His Ala Gln Trp Cys Gly Pro Cys Lys Ile Leu 
                 85                  90                  95
Gly Pro Arg Leu Glu Lys Met Val Ala Lys Gln His Gly Lys Val Val 
             100                105                110
Met Ala Lys Val Asp Ile Asp Asp His Thr Asp Leu Ala Ile Glu Tyr 
         115                120                125
Glu Val Ser Ala Val Pro Thr Val Leu Ala Ile Lys Asn Gly Asp Val 
     130                135                140
Val Asp Lys Phe Val Gly Ile Lys Asp Glu Asp Gln Leu Glu Ala Phe 
 145                150                155                160
Leu Lys Lys Leu Ile Gly 
                 165



<210> 8887
<211> 370
<212> DNA
<213> Rattus norvegicus
<308> U75392
<400> 8887

acagntgac  accttgtgc  gaatttgca  gatgaaagt  taattcggg  aagngacag  60
ttcattaag  gtaagaagt  agtgtggac  tcaagaacc  caccaccag  gaagttggc  120
cacttttcc  gtttggagg  gccagctag  gggtcaagc  taccccacc  tgacccaag  180
atcatgtga  ggattcttc  gtatctgct  tcttggatt  aggaagact  aagaccaac  240
ctttcagag  ggttttcct  cttcttgta  tggctggga  ggggggggg  caggagaca  300
tgtgatttc  cagtgattt  ctgtagtgt  gtccctctc  ctgaatggg  ggagataac  360
accatgccag  370



<210> 8888
<211> 26
<212> PRT
<213> Rattus norvegicus
<308> AAB18747
<400> 8888

Thr Xaa Asp Asn Leu Val Leu Asn Leu Gln Asp Glu Ser Leu Ile Arg 
  1               5                  10                  15
Gly Xaa Asp Ser Phe Ile Lys Gly Lys Lys 
             20                  25



<210> 8889
<211> 1342
<212> DNA
<213> Homo sapiens
<308> NM_007273
<400> 8889

gcagtacct  agccggagc  gggtagagg  gggccggca  ccccttctg  cctccagtg  60
cgccggcct  aagatcaga  atggcccag  acttgaagg  cttggcggg  cggctgccc  120
ccgggcccc  gggcatggg  acggccctg  agctgttgc  gggggccgg  gccgtggcc  180
acggtgtgc  cgaatctgt  ttcaccgtg  aaggcgggc  cagagccat  ttcttcaat  240
ggatcggtg  agtgcagca  gacactatc  tggccgagg  ccttcactt  aggatccct  300
ggttccagt  ccccattat  tatgacatt  gggccagac  tcgaaaaat  tcctcccct  360
caggctcca  agacctaca  atggtgaat  tctccctgc  agtgttgtc  cgacccaat  420
ctcaggagc  tcctagcat  taccagcgc  tagggctgg  ctacgagga  cgagtgttg  480
cgtccattg  caacgaggt  ctcaagagt  tggtggcca  gttcaatgc  tcacagctg  540
tcacccagc  ggcccaggt  tccctgttg  tccgccggg  gctgacaga  agggccaag  600
acttcagcc  catcctgga  gatgtggcc  tcacagagc  gagctttag  cgagagtac  660
cagctgctg  agaagccaa  caagtggcc  agcaggagg  ccagcgggc  caattcttg  720
tagaaaaag  aaagcagga  cagcggcag  aaattgtgc  ggccgaggg  gaggccgag  780
ctgccaaga  gcttggaga  gcactgagc  agaaccctg  ctacatcaa  cttcgcaag  840
ttcgagcag  ccagaatat  tccaagacg  tcgccacat  acagaatcg  atctatctc  900
cagctgaca  ccttgtgct  aacctacag  atgaaagtt  caccagggg  agtgacagc  960
tcatcaagg  taagaaatg  gcctagtca  caagaactc  acccccaga  gaagtggat  1020
tgcttctcc  gtttttgag  agccagcca  gggtccagc  cagccctac  ccgccccag  1080
atcatgcga  ggtccccca  accggttcc  tgaacccct  ttggattaa  gaagactga  1140
gactagccc  ttttctggg  aattacttt  ctcctccct  tgttaactg  ggctgttgg  1200
gacagtgcg  gatttctca  tgatttcct  cagtgttgt  ccctccctc  aggctggga  1260
gagataaac  ccaacccag  aattctcaa  aaattttta  tacttaacc  gaaaaaaaa  1320
aaaaaaaaa  aaaaaaaaa  aa  1342



<210> 8890
<211> 299
<212> PRT
<213> Homo sapiens
<308> NP_009204
<400> 8890

Met Ala Gln Asn Leu Lys Asp Leu Ala Gly Arg Leu Pro Ala Gly Pro 
  1               5                  10                  15
Arg Gly Met Gly Thr Ala Leu Lys Leu Leu Leu Gly Ala Gly Ala Val 
             20                  25                  30
Ala Tyr Gly Val Arg Glu Ser Val Phe Thr Val Glu Gly Gly His Arg 
         35                  40                  45
Ala Ile Phe Phe Asn Arg Ile Gly Gly Val Gln Gln Asp Thr Ile Leu 
     50                  55                  60
Ala Glu Gly Leu His Phe Arg Ile Pro Trp Phe Gln Tyr Pro Ile Ile 
 65                  70                  75                  80
Tyr Asp Ile Arg Ala Arg Pro Arg Lys Ile Ser Ser Pro Thr Gly Ser 
                 85                  90                  95
Lys Asp Leu Gln Met Val Asn Ile Ser Leu Arg Val Leu Ser Arg Pro 
             100                105                110
Asn Ala Gln Glu Leu Pro Ser Met Tyr Gln Arg Leu Gly Leu Asp Tyr 
         115                120                125
Glu Glu Arg Val Leu Pro Ser Ile Val Asn Glu Val Leu Lys Ser Val 
     130                135                140
Val Ala Lys Phe Asn Ala Ser Gln Leu Ile Thr Gln Arg Ala Gln Val 
 145                150                155                160
Ser Leu Leu Ile Arg Arg Glu Leu Thr Glu Arg Ala Lys Asp Phe Ser 
                 165                170                175
Leu Ile Leu Asp Asp Val Ala Ile Thr Glu Leu Ser Phe Ser Arg Glu 
             180                185                190
Tyr Thr Ala Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu Ala Gln 
         195                200                205
Arg Ala Gln Phe Leu Val Glu Lys Ala Lys Gln Glu Gln Arg Gln Lys 
     210                215                220
Ile Val Gln Ala Glu Gly Glu Ala Glu Ala Ala Lys Met Leu Gly Glu 
 225                230                235                240
Ala Leu Ser Lys Asn Pro Gly Tyr Ile Lys Leu Arg Lys Ile Arg Ala 
                 245                250                255
Ala Gln Asn Ile Ser Lys Thr Ile Ala Thr Ser Gln Asn Arg Ile Tyr 
             260                265                270
Leu Thr Ala Asp Asn Leu Val Leu Asn Leu Gln Asp Glu Ser Phe Thr 
         275                280                285
Arg Gly Ser Asp Ser Leu Ile Lys Gly Lys Lys 
     290                295



<210> 8891
<211> 3348
<212> DNA
<213> Rattus norvegicus
<308> U75916
<400> 8891

ctcgaggaa  actgcagct  gtggtgttg  gagacagca  gcagaccct  atcaacatc  60
catctctga  tgacagcga  tcggaagtg  aggatatct  ggaaatcga  tccaaccga  120
ctttttctc  agaggagag  cgccagcag  attctgatc  ggagtatca  tcctccact  180
agaagctga  ggagaggcc  agctcaaga  aggagacct  aggcagaat  tccaggatg  240
gtgccacac  cacgccgtt  aagtccacg  gggacatca  agctgcagg  gtcacagaa  300
ccaacaagg  acccaggtc  caggaagaa  ccccagttc  tcaacccag  acagcatca  360
gagtctttc  tcgtcctag  cccgaaaat  aagcaatat  tggccctaa  accaaaatg  420
tgaagttca  gaagggaga  agcgtgggc  tccggttgg  tggtggaaa  gatgttggc  480
tatttgtgg  tggcattca  gagggcacc  ctgcagagc  ggagggcct  caagaaggg  540
accagattc  gaaggtgaa  acacaagat  tcagagggc  ggtccggga  gatgccgtc  600
tctacctgt  agaaatccc  aaaggtgaa  ccgtgacca  tttggctca  agccgagca  660
acgtgtata  agacatcct  gcctgtggc  ggggagact  gttcttcat  aggagccac  720
ttgaatgtg  gaaggagac  ccgcagagc  tggccttca  caggggaga  gtcttccga  780
tggtagaca  gctgtacga  ggcaaactg  gccactggc  ggctgtgag  attggaaat  840
agctggaga  gggcttaat  cctaacaaa  gcagagctg  gcagatggc  agtgtccag  900
atgcccagc  agagaatgc  ggggacaga  cagacttct  gcggatgcg  ggccagaga  960
ccggggtca  gaagaacat  cgcaagagc  gggaagacc  ggcagctgc  gtgtcggtt  1020
gcaccaagt  ccccgccta  gaaaaggtt  tgcttcggg  agctggctt  aagaaaccc  1080
tggttctgt  tggccccat  gcagatata  caatggaaa  gctgactac  gagctaccc  1140
acctgtttc  aactgcaaa  acagaaccc  aagatgcgg  atctgagaa  tccagtgga  1200
tggttcggt  gaatactgt  aagcaaatt  ttgagcagg  caagcatgc  ctgctcgac  1260
ttaccccca  agctgtgga  ctgctccat  atactcagt  gttcccaat  gtgattttc  1320
tcaccccgg  ttccagaca  ggcattaaa  ccataaggc  gaagttgaa  ccaacatcc  1380
ataaaattt  tcgcaagtt  ttcgatcaa  cnaacaagt  caaaaaaac  tgttctcat  1440
ttttaacag  taccatcaa  gtgaattca  ccaatgatg  ctggtttgg  agcctgaag  1500
acagcattc  gcagcagca  cacgaagca  tgtgggttt  tgaaggaaa  atggagggg  1560
tggatgatg  cgctgaaga  cgcatgtcc  acttaaccg  catgggtgc  gactatctg  1620
gttgtgaca  ccgtctcat  agtgacttt  aagatacgg  cggcgaggg  ggcgcctac  1680
ctgacaatg  gctggatga  ccagctgag  agccgctgg  gtcttccat  acccgctcc  1740
cagagccgg  gcagcatga  gagagcata  ggaagccca  cccagagcc  cgcgctcag  1800
tgaggaggg  agctagcag  gaccagctt  gggatggta  cccgccccc  gcattcaag  1860
cagagccgc  caaggtcag  aaccaaaac  gagaggact  tttcaacta  tccaagtca  1920
acttttctg  catggctgg  agtgaaatc  cggggggat  caccaaagg  tgtcctccc  1980
ctattgcgg  gaaacctgc  tttgggcga  ccatcctga  gccttctac  ccagtcccc  2040
tgcctgaga  tgaggaggt  ggggagagc  ccgaggagc  ggaagaggc  cccaaatca  2100
tcctgggca  agtgaaaat  ttcgagaag  tggaccaca  ggcgaaatt  cagaggatg  2160
aggagctcc  agaagcaca  aatgcgagg  ttgaaatag  tcagaagca  cctgacatc  2220
atgcggttc  aatcaaagc  cccaagcca  atgctggcc  gccccagca  atgagttct  2280
gacccccag  gccacagaa  gctccttct  ggctttacc  ggacaccag  ggaagctac  2340
gcagtgatc  cgaggaaga  gaggagtac  gccaacagt  ggcagcaca  tcgaagcgt  2400
gttactaca  ccagccctc  cggtaccga  acaccgaat  atagagggc  acttgtgga  2460
tcctgcgag  ctccctgga  gtcttctcc  gttaaaatg  actgcagag  tacggtggg  2520
atccaggca  cagacagct  gaattatca  ccgaaggct  tgttcgtgg  actggagta  2580
agttggtta  gactttttg  atgaagaga  acactatag  ctgataatg  ttacttgct  2640
tggtgtgga  caaaaatct  tattaatct  tctgtattt  taatatgta  attgagcaa  2700
aactccttc  cctcgttca  agctgcctt  cagagctgc  tcgatgtga  gcaaatgtg  2760
acagggagt  aaaaaaaaa  aagtactcc  tctcaaact  aatccagaa  taatttatc  2820
cgactccct  agtgccttt  acaagatgt  tcttagttt  cttccctga  gctttatgc  2880
aagctataa  ggactaaaa  ttttatttt  actaaattt  tataccagt  tagcagctg  2940
aactgccct  agcaccatg  caccttttc  gggcattat  ttgggagtg  ggctattag  3000
tctacatag  tcggaggcc  agttttatt  gagtgtttg  ccttgtttg  ctgaaacca  3060
gtgctccac  aagtcagag  cttgagaaa  gggtatttt  tttccttcc  atcagcata  3120
gtactgaca  caggtggtt  tataattta  taaaaagga  taccttgtg  tcaagaatg  3180
gctttgtgc  gaatntnta  acaccttcc  tttgggctg  gtggggtgg  atccaagat  3240
ctcatgcat  cagagtgct  ctccaccgc  gaactatac  ccagacttc  tgatttatt  3300
tattttaat  aaaaaaatt  aaaagactt  aaaaaaaaa  aaaaaaaa  3348



<210> 8892
<211> 1811
<212> DNA
<213> Homo sapiens
<308> AK025185
<400> 8892

aaaagctaa  ggagttaga  ttacttaga  aataagatt  gttgagaat  tgccatcgt  60
ctgggagtt  gaatgggtg  tatgagaac  ttagggaat  tgtctaggc  tctagaatt  120
gatcgcttc  ccctcgggg  gatagctca  acacagctg  gctgcaggg  ggagagagg  180
agattctat  acctgtggc  gcttttatt  tagaagctt  tggtgttag  atcctgttc  240
ccagctgaa  tgaggtagt  ttgtgagac  tgacagtga  tattttgtt  cagaattga  300
taagttttg  tctttgaga  ctagatgtg  agtcaaagt  tctggcatc  atggagtgc  360
tccagtttg  aagggggat  caagcttcc  tggggagga  aggttgaac  ggacatagc  420
tctgccttt  agggtctga  aatcttgta  aggcatgga  gtgagtgta  cacaaggca  480
cgtgcaatg  gttgatatt  ctaggagag  ggtaccagg  gaacaggct  cagaggagc  540
ggattcaga  gaaaagcaa  acagactga  aaagtgtgg  ttagccgcg  tatggagga  600
ggatggtag  acagatagg  tgcagggcc  ctaatttga  ttcctgcac  aaaacgacc  660
taatatcaa  attgtacca  agccaagtg  tctcaggga  aaaaataaa  gatgccttc  720
ctggcgagc  catcaaggt  tcagtcgct  ggctgtgtc  ttgggaatt  tcttgagtc  780
ccactccca  gagccacat  agaccccac  gaccgtcca  cacaaattc  tctagatgg  840
agggatgga  gatgacccc  aagaccgca  gtcctactt  actgccatg  gcgcagact  900
tctgagttg  gacagccgc  tcatcagtg  ctttgaaga  acggacggt  aaggaggcg  960
ctacactga  aatgagctg  atgagccag  cgaggagcc  ctggtgtcg  ccatcaccc  1020
ctcctcgga  ccggtgcag  acgaggagg  gaggcgagg  aggccacgg  caggaacag  1080
agagcctgg  gttttcctt  cactctcgt  gacagctgt  tgttcaggg  gctgtggaa  1140
gcattccta  gggttggag  agatgactt  cagggagtc  ctcgctttg  gtccacgct  1200
gcatggttg  agtctgtgg  aaagtgggg  aggcaggtg  acttcagaa  agcttgagg  1260
gtcagcact  cgcacaccc  tgccctcag  tgcgatgga  aaacagaat  gctttaggt  1320
ccgtctgtc  aaattacca  cggaacctt  cttcccatg  agtattgtt  tatgtactt  1380
taacctttg  ttaggtttc  ctctgtact  ttagatgtc  ttgcttttc  tccccatcc  1440
gcctttaac  tttctaatc  tgccaaagc  cttgagtgt  tccccatca  tttccttct  1500
tcttatatt  cagtttttt  attgagttc  tgatcaaac  ttcatctga  cacatcaca  1560
gtactgtgc  tccactgtg  ttagatagc  tatgggatc  ttgaaatca  attgacagg  1620
actgtaagt  acagccaag  tagcaatta  tagttgcac  tcagagaat  ttggaataa  1680
gatctttga  gatgggatt  ttcatatat  tggataatt  ttgctgtgg  tttctctct  1740
gcattttag  tcattccag  aaatgattt  tttctttat  aaatagaac  accaaaaaa  1800
aaaaaaaaa  a  1811



<210> 8893
<211> 464
<212> DNA
<213> Rattus norvegicus
<308> U75920
<400> 8893

cggagccgg  cgcgcggac  gcggacgcg  gtcctgtga  agccgaaga  ggcagtgaa  60
gtgtactcg  cgtcagtca  cagtgataa  ctcagtcga  atgacatgc  ggcttggat  120
aatgaatct  tgcagttga  tctgacaaa  atagaacag  tatgttcag  ggctgcata  180
tgtcagttc  tggacatgc  cttccccgg  tccattgcc  tgaagaaag  gaaattccn  240
gctaagcta  aacatgaat  tatccagaa  ttcaaaata  tacaagccg  cttcaagaa  300
atgggcttg  caaaataat  cctgtggat  aattagtaa  angaaaatt  aggacattt  360
gaattccnt  catggttcn  aantttttg  tgcnntttt  attggaaan  ttttatcct  420
tcccgccaa  aagncaaaa  gnatggncc  ccttgtccc  cccc  464



<210> 8894
<211> 89
<212> PRT
<213> Rattus norvegicus
<308> AAB81885
<400> 8894

Met Ala Val Asn Val Tyr Ser Thr Ser Val Thr Ser Asp Asn Leu Ser 
  1               5                  10                  15
Arg His Asp Met Leu Ala Trp Ile Asn Glu Ser Leu Gln Leu Asn Leu 
             20                  25                  30
Thr Lys Ile Glu Gln Leu Cys Ser Gly Ala Ala Tyr Cys Gln Phe Met 
         35                  40                  45
Asp Met Leu Phe Pro Gly Ser Ile Ala Leu Lys Lys Val Lys Phe Xaa 
     50                  55                  60
Ala Lys Leu Glu His Glu Tyr Ile Gln Asn Phe Lys Ile Leu Gln Ala 
 65                  70                  75                  80
Gly Phe Lys Lys Met Gly Leu Thr Lys 
                 85



<210> 8895
<211> 2540
<212> DNA
<213> Homo sapiens
<308> NM_012325
<400> 8895

acgagacga  gacggaacc  gagccggtt  cgggcagtg  acgcggttc  gccgagagc  60
gaagatggc  gtgaacgta  actcaacgt  agtgaccag  gataaccta  gtcgacatg  120
catgctggc  tggatcaat  agtctctgc  gttgaatct  acaaagatc  aacagttgt  180
ctcaggggc  gcgtattgt  agtttatgg  catgctgtt  cctggctcc  ttgccttga  240
gaaagtgaa  ttccaagct  agctagaac  cgagtacat  cagaacttc  aaatactac  300
agcaggttt  aagagaatg  gtgttgaca  aataattcc  gtggacaaa  tagtaaaag  360
aaagtttca  gacaatttt  aattcgttc  gtggttcaa  aagtttttc  atgcaaact  420
tgatggaaa  gactatgac  ctgtggctg  cagacaagg  caagaaact  cagtggctc  480
ttcccttgt  gctccagct  tgaataaac  gaagaaacc  ctcacttct  gcagtgcag  540
tccccagag  cccatctca  cacagagaa  cgctgcggc  cctaaggct  gccctggtg  600
ggtgcgaaa  aaccctggt  tgggcaacg  agacgacga  gcagctgag  tgatgcagc  660
ggtcaacgt  ttgaaactt  ctgttgaag  cttggagaa  gagagggat  tctacttcg  720
aaagctacg  aacattgaa  tgatttgcc  ggagaacga  ggggaaaac  accctgtat  780
gcagaggat  gtagacatt  tgtatgcca  agatgaagg  tttgtgata  ctgatgaag  840
gggcccaca  gaggagcaa  aagagtatt  acagcctgg  ccagcagag  aacatcgga  900
ttcttcact  caaatcatg  gcttaactg  aaaatactc  cttttgtta  ccttagagg  960
ctcactggt  tcttttcat  agcaaaaag  acctcttct  aaagtgcac  ttgcagacg  1020
ttcactcct  ttccaataa  tttgagtta  gagctttta  cttgtagca  agcagtatt  1080
acatctagt  ggttcacct  gaaaacaga  aggctgacc  tggggctca  catgcggat  1140
cgggtcaca  tgaatgctg  agagatgta  gtaatatgc  gaggtggcg  cctcagtgg  1200
gaaatgtaa  gactgaatt  aattttaag  taatgtgaa  tcagagaat  ttgtaataa  1260
taaatgcct  aagagtatt  aaaatatgc  tccacattt  aaaatataa  atgtaacat  1320
acaagagat  ttgcgtttg  cattgtgtc  gggaaggaa  ggccagacc  tggaacctt  1380
ggaacctgc  gtcaacagg  cttacaggg  tgcttgaac  ctcataggc  taggctttg  1440
tctaaaagg  acatttaaa  agttgccct  taaagttat  tggtgtcat  gaccaattg  1500
atcccagct  aaaagcaag  ggcatcgtt  cctggataa  agaggatgt  tttcagccc  1560
gagatgtta  agttgaaga  cttggtttc  ttgagcatt  ctctatttt  ccagttatc  1620
cgaaatttc  atgtattat  ttttgggga  gtgaggtgt  cccagtttt  taatctaac  1680
actactttt  gggacttgc  cacatctct  ggatttgaa  ggggattgt  tcccatttt  1740
ctgtctttt  ggtttacat  taccacgtt  ctcttctct  ctccccttg  ccactggga  1800
tcctctttg  ctccttgaa  tttgctgct  agagttgga  gtgcagcag  caggtgatc  1860
tgctgcaag  tctttctgg  cctctggca  agggagtgg  cagtgaagg  catcgttac  1920
ttgggatct  ccaggctgg  gtgttttcg  tatctgctg  tcacagctc  ccactgtaa  1980
ccgaatact  tgccagtgc  ctaatctct  tggagataa  attcattag  gtgttacta  2040
atgttaatt  tcttttgcg  aaaatacag  accgtgtct  aattaatta  taatattta  2100
aatacttca  tccttaact  tccctcatt  gctttgccc  cagcctatt  agttccttt  2160
tttggcagg  ttctgcaaa  tgtgtctca  ccactactg  gattgttca  cccctgatg  2220
atttgtatt  atttgtttc  ggtggtagc  tgtcctgaa  tgtgtgtag  aagcaagta  2280
tttatgata  aaatgttgt  tagtgcatg  tctgtgtgg  attcagagg  aaacccaga  2340
tcagtgatt  acaatgcca  aaaatgcaa  taactagcc  ttgttcaaa  gacagtggt  2400
ctatttctc  tttgtggcc  tttagactt  tgttgccct  aaattccat  ttattggga  2460
cccattttc  acctggtct  tcttgacag  gtttttttc  actttaaac  gtttctaaa  2520
aaaattctg  atttcaaaaa  2540



<210> 8896
<211> 268
<212> PRT
<213> Homo sapiens
<308> Q15691
<400> 8896

Met Ala Val Asn Val Tyr Ser Thr Ser Val Thr Ser Asp Asn Leu Ser 
  1               5                  10                  15
Arg His Asp Met Leu Ala Trp Ile Asn Glu Ser Leu Gln Leu Asn Leu 
             20                  25                  30
Thr Lys Ile Glu Gln Leu Cys Ser Gly Ala Ala Tyr Cys Gln Phe Met 
         35                  40                  45
Asp Met Leu Phe Pro Gly Ser Ile Ala Leu Lys Lys Val Lys Phe Gln 
     50                  55                  60
Ala Lys Leu Glu His Glu Tyr Ile Gln Asn Phe Lys Ile Leu Gln Ala 
 65                  70                  75                  80
Gly Phe Lys Arg Met Gly Val Asp Lys Ile Ile Pro Val Asp Lys Leu 
                 85                  90                  95
Val Lys Gly Lys Phe Gln Asp Asn Phe Glu Phe Val Gln Trp Phe Lys 
             100                105                110
Lys Phe Phe Asp Ala Asn Tyr Asp Gly Lys Asp Tyr Asp Pro Val Ala 
         115                120                125
Ala Arg Gln Gly Gln Glu Thr Ala Val Ala Pro Ser Leu Val Ala Pro 
     130                135                140
Ala Leu Asn Lys Pro Lys Lys Pro Leu Thr Ser Ser Ser Ala Ala Pro 
 145                150                155                160
Gln Arg Pro Ile Ser Thr Gln Arg Thr Ala Ala Ala Pro Lys Ala Gly 
                 165                170                175
Pro Gly Val Val Arg Lys Asn Pro Gly Val Gly Asn Gly Asp Asp Glu 
             180                185                190
Ala Ala Glu Leu Met Gln Gln Val Asn Val Leu Lys Leu Thr Val Glu 
         195                200                205
Asp Leu Glu Lys Glu Arg Asp Phe Tyr Phe Gly Lys Leu Arg Asn Ile 
     210                215                220
Glu Leu Ile Cys Gln Glu Asn Glu Gly Glu Asn Asp Pro Val Leu Gln 
 225                230                235                240
Arg Ile Val Asp Ile Leu Tyr Ala Thr Asp Glu Gly Phe Val Ile Pro 
                 245                250                255
Asp Glu Gly Gly Pro Gln Glu Glu Gln Glu Glu Tyr 
             260                265



<210> 8897
<211> 219
<212> DNA
<213> Rattus norvegicus
<308> U75923
<400> 8897

gagagagtg  ttactttga  ttaatcaaa  ttaaaatat  tcatcaaat  acccaggaa  60
atccaggta  cagaaatat  taacatatc  atttcttac  aggtcacaa  tcagtttta  120
aaggctata  atatatgta  gtatatgta  tatgccatt  aaaccactt  cgctttctg  180
actgaagaa  tcgagwnwg  aataagctt  gtggtgcta  219



<210> 8898
<211> 50
<212> PRT
<213> Rattus norvegicus
<308> AAB81886
<400> 8898

Met Gln Thr Ser Leu Gly Asn Phe Val Thr Thr Thr Gly Ile Ser Ser 
  1               5                  10                  15
Thr Arg Thr Pro Arg Pro Arg Arg Glu Ser Val Tyr Phe Asp Leu Ile 
             20                  25                  30
Lys Leu Lys Ile Phe His Gln Ile Thr Gln Glu Asn Pro Gly Ser Arg 
         35                  40                  45
Asn Ile 
     50



<210> 8899
<211> 234
<212> DNA
<213> Rattus norvegicus
<308> U75927
<400> 8899

aatggttaa  gactgcttt  ttggtggca  ttaatacac  tcaataaat  ttgatcccc  60
tagaagagt  cagttattc  tcaggttcc  ggtccatcg  gcagtgaat  aaactgaac  120
atgtggaga  tgggatgac  acgtcagtt  tgcttcttg  ggaatgcag  catagctaa  180
atatagatg  catacgctg  tccaccaac  gtcagaagc  ttgtggctc  gtaa  234



<210> 8900
<211> 83
<212> PRT
<213> Rattus norvegicus
<308> NP_071948
<400> 8900

Met Leu Arg Asn Val Leu Ala Leu Arg Gln Ile Ala Gln Arg Thr Ile 
  1               5                  10                  15
Ser Thr Thr Ser Arg Arg His Phe Glu Asn Lys Val Pro Glu Lys Gln 
             20                  25                  30
Lys Leu Phe Gln Glu Asp Asn Gly Met Pro Val His Leu Lys Gly Gly 
         35                  40                  45
Thr Ser Asp Ala Leu Leu Tyr Arg Ala Thr Met Leu Leu Thr Val Gly 
     50                  55                  60
Gly Thr Ala Tyr Ala Ile Tyr Met Leu Ala Met Ala Ala Phe Pro Lys 
 65                  70                  75                  80
Lys Gln Asn 
                 85



<210> 8901
<211> 470
<212> DNA
<213> Homo sapiens
<308> NM_001865
<400> 8901

gtagttccg  ttccggcgt  gccattttc  ttggtggtg  tcagttgtg  cggttgctg  60
tcagtaaca  ccaagatgc  gcggaatct  ctggctctt  gtcagattg  gcagaggac  120
ataagcact  cttcccgca  gcattttaa  aataaagtt  cggagaagc  aaaactgtt  180
caggaggat  atgaaattc  actgtatct  aagggtggg  tagctgatg  cctcctgta  240
agagccacc  tgattctta  agttggtgg  acagcatat  ccatatatg  gctggctgt  300
gcttcattt  ccaagaagc  ggagtgact  cagtcatcc  agcaatcgc  tggttcagt  360
tcattcagc  ctctatgga  cagtaatct  ataaataac  gagctcttc  ttggggatc  420
atatttatt  acttgtagt  actgccacc  ataaagcag  ctttaccatg  470



<210> 8902
<211> 83
<212> PRT
<213> Homo sapiens
<308> P14406
<400> 8902

Met Leu Arg Asn Leu Leu Ala Leu Arg Gln Ile Gly Gln Arg Thr Ile 
  1               5                  10                  15
Ser Thr Ala Ser Arg Arg His Phe Lys Asn Lys Val Pro Glu Lys Gln 
             20                  25                  30
Lys Leu Phe Gln Glu Asp Asp Glu Ile Pro Leu Tyr Leu Lys Gly Gly 
         35                  40                  45
Val Ala Asp Ala Leu Leu Tyr Arg Ala Thr Met Ile Leu Thr Val Gly 
     50                  55                  60
Gly Thr Ala Tyr Ala Ile Tyr Glu Leu Ala Val Ala Ser Phe Pro Lys 
 65                  70                  75                  80
Lys Gln Glu 
                 85



<210> 8903
<211> 2899
<212> DNA
<213> Rattus norvegicus
<308> U75973
<400> 8903

agaaagacc  aagttgcca  agatgtgga  cgctcagca  gacagcgac  ccgcggagg  60
cctgggacg  cgccaacgc  ggttctgtg  tggaacact  gtgctggct  tcactggaa  120
cttcatcat  ggcttcctc  ttgggtggt  tataaaacc  tccaatgat  ctactagca  180
tgtttccta  cctggcatg  agaaggcat  tttgcaaga  ttgaaggct  agaacatca  240
aaaattttt  tacaatttc  cacggacac  acatttggc  gggacacaa  acaattttg  300
gcttgcaaa  caaattcat  cccagtgga  agaatttgg  ctggatttg  ttgagttat  360
tgattatga  gtcctgttg  cctacccaa  taagaccca  cccaactat  tctcaataa  420
taatgaaga  ggaaatgag  ttttcaaaa  atcattagc  gaactgtca  ccccgggat  480
tgagaacat  tcagatgta  tgccaccat  cagtgcctt  tctccacaa  ggacaccag  540
gggggatct  gtatatgtt  actatgcac  aactgaaga  ttctttaaa  tggaacggg  600
catgaagat  aattgttct  ggaagattg  catcgccag  tatgggcaa  tgttcagag  660
aaataaggt  aaaaatgct  agctggcag  tgcaaaagg  atcattctg  actcagacc  720
tgctgatta  tttgttcct  gggtgaagt  ctatccaga  ggttggaac  tccctggag  780
tggtgttca  cgtggaaat  tcttaaatc  taatggtgc  ggtgatccc  tcacaccag  840
ttatccagc  aatgaatat  cctacaggc  tgaattcac  gaagctgtc  gtcttccaa  900
tattcctgt  catccaatt  gatatgatg  tgcacagaa  ctattagaa  atatgggtg  960
ctccgcacc  cctgacagc  gctggaagg  aggactaaa  gtgccttac  acgtgggac  1020
tggctttgc  ggaaacttt  caaaacaaa  ggtcaagct  catattcac  cctacaata  1080
agtgacaag  atctacaat  ttattggta  cctcaaagg  gctgtggaa  cagacagat  1140
tgttattct  ggagggcac  gagatgctt  ggtgtttgg  ggcattgac  ctcagagtg  1200
agcagctgt  gttcatgaa  ttgtcagga  ctttggaac  ctgaagaag  aaggttgga  1260
gcctagaag  actattttg  ttgcaagct  ggatgctga  gaatttggc  ttcttggtt  1320
tactgagtg  gcagaggaa  attcaagac  cttacaaga  cgtggtgtg  cttatatca  1380
cgctgattc  tccatagaa  gaaactaca  tctcagagt  gattgcaca  cactgatgc  1440
cagcttagt  tacaaccta  caaaagagc  gccaagccc  gatgaaggc  ttgaaggca  1500
atctcttta  gacagctgg  aagaaaaaa  tccttcaac  gagttcatt  gaatgccaa  1560
gattagcaa  ctggggtct  gcaatgatt  tgaagtgtt  ttccaaaga  ttggaattg  1620
ttcaggcag  gcccggtat  ctaaaaatt  gaaaaacaa  aaagtcagc  gctatcctc  1680
ctatcacag  gtctatgaa  catacgaat  ggtagaaaa  ttctatgat  cgacattta  1740
atatcacct  actgtggcc  aggttcgag  agcaatggt  tttgaattg  ccaattcta  1800
agtgcttcc  tttgactgc  aaagttatg  tgtagctct  aagaaacat  ctgagacta  1860
ctacaacat  tcaatgaat  atccacagg  gatgaaggc  tacatgata  catttgatt  1920
gctgttttc  gcagtaaat  attttacag  tgttgcatc  aagttcaat  agagactgc  1980
agacttaga  aagagcaac  ccatattac  gagaatttt  aatgatcag  taatgtatc  2040
ggaacgtgc  ttcattgat  ctttaggat  accaggaag  cctttctac  ggcatatca  2100
ctatgctcc  agcagccac  acaagtatg  aggagaatc  ttcccaggg  tttatgatg  2160
cctttttga  attaataac  aagtcgaca  ttctaaggc  tggagagaa  tgaagagac  2220
gatttctat  gcagccttc  cagtgcaag  tgcagcaga  actctgaga  aagtagact  2280
agcagtctt  acagaattc  taaaaaact  atttgtgga  caaaagaca  aagtgaata  2340
tttcataat  acttataat  ttggcatgt  ttactaaaa  ttaaaattc  ataggtatt  2400
aaactaatg  aaacagcct  ataaaatga  acatttgac  gtattagat  attatccga  2460
atctaatac  cccttccca  atctaccct  tagttttac  tcattatgg  atacatctt  2520
gatagttca  aattctgct  tacctgggg  cctatatgc  ctctggtca  caaaggctg  2580
gaggatcat  atagtcacc  tagcagacg  gttctaatt  attctctct  cttgtaaac  2640
taattcctc  ttattgaaa  gtttaagta  ataggccaa  gtcttgtct  tggctccct  2700
tggaggatc  tgataaaaa  cggcagtcc  tggttttaa  gtatttatg  tctaaaact  2760
tataaattg  aaaagtaca  ctactaatt  acatctata  tctcagtaa  tgaacttct  2820
aacaaatgc  ttatttata  gaaatataa  catggtctt  aattttatg  ttataatgt  2880
tctttttat  tagaattac  2899



<210> 8904
<211> 752
<212> PRT
<213> Rattus norvegicus
<308> P70627
<400> 8904

Met Trp Asn Ala Gln Gln Asp Ser Asp Ser Ala Glu Ala Leu Gly Arg 
  1               5                  10                  15
Arg Gln Arg Trp Phe Cys Ala Gly Thr Leu Val Leu Ala Phe Thr Gly 
             20                  25                  30
Thr Phe Ile Ile Gly Phe Leu Phe Gly Trp Phe Ile Lys Pro Ser Asn 
         35                  40                  45
Asp Ser Thr Ser Ser Val Ser Tyr Pro Gly Met Lys Lys Ala Phe Leu 
     50                  55                  60
Gln Glu Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr 
 65                  70                  75                  80
Arg Thr Pro His Leu Ala Gly Thr Gln His Asn Phe Glu Leu Ala Lys 
                 85                  90                  95
Gln Ile His Ala Gln Trp Lys Glu Phe Gly Leu Asp Leu Val Glu Leu 
             100                105                110
Ser Asp Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn 
         115                120                125
Tyr Ile Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Lys Thr Ser 
     130                135                140
Leu Ala Glu Leu Ser Pro Pro Gly Tyr Glu Asn Ile Ser Asp Val Val 
 145                150                155                160
Pro Pro Tyr Ser Ala Phe Ser Pro Gln Gly Thr Pro Glu Gly Asp Leu 
                 165                170                175
Val Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg 
             180                185                190
Val Met Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly 
         195                200                205
Gln Val Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala 
     210                215                220
Lys Gly Ile Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Val Pro Gly 
 225                230                235                240
Val Lys Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln 
                 245                250                255
Arg Gly Asn Val Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro 
             260                265                270
Gly Tyr Pro Ala Asn Glu Tyr Ala Tyr Arg His Glu Phe Thr Glu Ala 
         275                280                285
Val Gly Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Asp Asp Ala 
     290                295                300
Gln Lys Leu Leu Glu His Met Gly Gly Ser Ala Pro Pro Asp Ser Ser 
 305                310                315                320
Trp Lys Gly Gly Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Ala 
                 325                330                335
Gly Asn Phe Ser Lys Gln Lys Val Lys Leu His Ile His Ser Tyr Asn 
             340                345                350
Lys Val Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Lys Gly Ala Val 
         355                360                365
Glu Pro Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ala Trp Val 
     370                375                380
Phe Gly Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile 
 385                390                395                400
Val Arg Thr Phe Gly Thr Leu Lys Lys Lys Gly Trp Arg Pro Arg Arg 
                 405                410                415
Thr Ile Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly 
             420                425                430
Ser Thr Glu Trp Ala Glu Glu His Ser Arg Leu Leu Gln Glu Arg Gly 
         435                440                445
Val Ala Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu 
     450                455                460
Arg Val Asp Cys Thr Pro Leu Met His Ser Leu Val Tyr Asn Leu Thr 
 465                470                475                480
Lys Glu Leu Pro Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr 
                 485                490                495
Asp Ser Trp Lys Glu Lys Ser Pro Ser Thr Glu Phe Ile Gly Met Pro 
             500                505                510
Arg Ile Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln 
         515                520                525
Arg Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Lys 
     530                535                540
Asn Asn Lys Val Ser Ser Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr 
 545                550                555                560
Tyr Glu Leu Val Glu Lys Phe Tyr Asp Pro Thr Phe Lys Tyr His Leu 
                 565                570                575
Thr Val Ala Gln Val Arg Gly Ala Met Val Phe Glu Leu Ala Asn Ser 
             580                585                590
Ile Val Leu Pro Phe Asp Cys Gln Ser Tyr Ala Val Ala Leu Lys Lys 
         595                600                605
His Ala Glu Thr Ile Tyr Asn Ile Ser Met Asn His Pro Gln Glu Met 
     610                615                620
Lys Ala Tyr Met Ile Ser Phe Asp Ser Leu Phe Ser Ala Val Asn Asn 
 625                630                635                640
Phe Thr Asp Val Ala Ser Lys Phe Asn Gln Arg Leu Gln Asp Leu Asp 
                 645                650                655
Lys Ser Asn Pro Ile Leu Leu Arg Ile Leu Asn Asp Gln Leu Met Tyr 
             660                665                670
Leu Glu Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Gly Arg Pro Phe 
         675                680                685
Tyr Arg His Ile Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly 
     690                695                700
Glu Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Asn Asn Lys 
 705                710                715                720
Val Asp Thr Ser Lys Ala Trp Arg Glu Val Lys Arg Gln Ile Ser Ile 
                 725                730                735
Ala Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Arg Glu Val Asp 
             740                745                750



<210> 8905
<211> 573
<212> DNA
<213> Homo sapiens
<308> AF254357
<400> 8905

cctttcagt  ctttctctc  tcaaggaat  ccagagggc  atctagtgt  tgttaacta  60
gcacgaact  aagacttct  taaattgga  cgggacatg  aaatcaatt  ctctgggaa  120
attgtaatt  ccagatatg  gaaagtttt  agaggaaat  agaatatgc  tataggcgt  180
gaattgcag  ggctgttgg  cttccaagt  ttcctgttc  tccaattgg  tactatgat  240
cacagaagc  cctagaaaa  atgggtggc  cagcaccac  agatagcag  tggagagga  300
gtctcaaag  gccctacaa  gttggacct  gctttactg  aaacttttc  acacaaaaa  360
tcaagatgc  catccactc  accaatgaa  tgacaagaa  ttacaatgt  ataggtact  420
tcagaggag  agtggaacc  gacagatat  tcattctgg  aggtcaccg  gactcatgg  480
tgtttggtg  tattgaccc  cagagtgga  cagctgttg  tcatgaaat  gtgaggagc  540
ttggaacac  gaaaaagga  gggtggaga  cta  573



<210> 8906
<211> 750
<212> PRT
<213> Homo sapiens
<308> Q04609
<400> 8906

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
  1               5                  10                  15
Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
             20                  25                  30
Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
         35                  40                  45
Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
     50                  55                  60
Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
 65                  70                  75                  80
Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                 85                  90                  95
Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
             100                105                110
Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
         115                120                125
Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
     130                135                140
Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
 145                150                155                160
Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                 165                170                175
Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
             180                185                190
Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
         195                200                205
Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
     210                215                220
Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
 225                230                235                240
Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                 245                250                255
Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
             260                265                270
Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
         275                280                285
Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
     290                295                300
Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
 305                310                315                320
Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                 325                330                335
Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
             340                345                350
Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
         355                360                365
Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
     370                375                380
Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
 385                390                395                400
Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                 405                410                415
Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
             420                425                430
Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
         435                440                445
Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
     450                455                460
Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
 465                470                475                480
Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                 485                490                495
Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
             500                505                510
Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
         515                520                525
Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
     530                535                540
Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
 545                550                555                560
Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                 565                570                575
Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
             580                585                590
Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
         595                600                605
Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
     610                615                620
Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
 625                630                635                640
Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                 645                650                655
Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
             660                665                670
Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
         675                680                685
His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
     690                695                700
Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
 705                710                715                720
Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                 725                730                735
Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
             740                745                750



<210> 8907
<211> 1690
<212> DNA
<213> Rattus norvegicus
<308> U76206
<400> 8907

aattctctc  tccgcaccc  gggttctgt  gatgaaact  gcctctgag  atcctgaac  60
tggagaaat  gagataaat  ccccagaag  gggggagta  gtgttcaca  ccttggtgg  120
tttcgcctc  tgtctgtcc  tccacttta  gagatgccg  tcacctgag  gccacaaac  180
gcgctctaa  taaccagcc  gcctttcta  ccagatctt  gtctccaga  gtgagaaga  240
ggacaacac  acaaccaca  aacctccaa  gcagccctg  acccggaac  ccctgatca  300
acagcagat  atccccatg  tgtactgtg  ggtcttcat  acaggggtc  tcctcaacg  360
aatatcggg  tggatattc  tttacgtgc  cagctctaa  agttttatc  tctatctca  420
gaacatagt  gtggctgac  ttctcatgg  cctcacttt  cctttcaaa  tcctcagcg  480
ctcaggcct  ggtccctgg  agctgaatg  gtttgtatt  agggtgtct  ccgtgatct  540
ctacgtcaa  atgtacgtc  gcatcgcgt  cttcgggct  atcagcttt  acaggtact  600
taaaatcgt  aagcccctt  tggtgtcta  cgtccagtc  gtgaactac  gcaaagtgc  660
gtccgtgct  gtgtgggtg  tcatgcttc  cctcgctgt  cccaacatc  ttctgacaa  720
ccagagtgt  aaggatgtc  ctaacatac  gtgcatgga  ctcaaaaac  agctggggc  780
gaagtggca  aaggcgtct  actatgtct  cgtgagcat  ttctggatc  tgttccttc  840
gctgaccgt  ttctacatg  ccataacga  gaagatctt  aagtctcac  tcaagtcca  900
aaagaattc  atctccgtc  aaaggaagt  cagccgcaa  atattcagc  ttgtgctcg  960
atttgtcgc  tgtttcgcg  cttaccacg  tgccaggat  ccctacacc  agagccaga  1020
ggaaggaca  tacagctgc  aggccaagg  gaccctgct  tatacgaaa  aattcaccc  1080
gctgctctc  gctgccaat  tgtgtctgg  ccccatatc  atttcttct  atgccagcc  1140
tttagagaa  tcttgaata  gaagttaag  atgtcacta  cagtccaga  tgacctaga  1200
acttccaaa  ccagaaggg  aaatatgat  caggaaagc  cagatactt  gcaattctc  1260
ccctttcca  gtattatgg  ccttgttac  cggtaatta  gatgtatga  gtgaaaagc  1320
gaaaagtat  ataaaaatg  aaggtaagt  cccatgtaa  gtgaaagtc  acagcacgc  1380
gaaaagtat  ataaaaatg  aaggtaagt  cccatgtaa  gtgaaagtc  acagcacgt  1440
acatctttt  agaaatcga  tggagaagt  gcatgtggg  gctagtctg  gagttaccc  1500
aaaactaaa  tctctcttc  attaacggg  ttcttagaa  acacccacc  tttcagaag  1560
tcctcctga  tatccttct  agtaatgct  acctctgtt  catgctttg  tctgtgtat  1620
cgccaataa  caagttgtc  ttaaaaccc  aaaaaaaaa  aaaaaaaaa  gtactagtc  1680
acgcgtggcc  1690



<210> 8908
<211> 305
<212> PRT
<213> Rattus norvegicus
<308> O35881
<400> 8908

Met Asp Asn Thr Thr Thr Thr Glu Pro Pro Lys Gln Pro Cys Thr Arg 
  1               5                  10                  15
Asn Thr Leu Ile Thr Gln Gln Ile Ile Pro Met Leu Tyr Cys Val Val 
             20                  25                  30
Phe Ile Thr Gly Val Leu Leu Asn Gly Ile Ser Gly Trp Ile Phe Phe 
         35                  40                  45
Tyr Val Pro Ser Ser Lys Ser Phe Ile Ile Tyr Leu Lys Asn Ile Val 
     50                  55                  60
Val Ala Asp Phe Leu Met Gly Leu Thr Phe Pro Phe Lys Val Leu Ser 
 65                  70                  75                  80
Asp Ser Gly Leu Gly Pro Trp Gln Leu Asn Val Phe Val Phe Arg Val 
                 85                  90                  95
Ser Ala Val Ile Phe Tyr Val Asn Met Tyr Val Ser Ile Ala Phe Phe 
             100                105                110
Gly Leu Ile Ser Phe Asp Arg Tyr Tyr Lys Ile Val Lys Pro Leu Leu 
         115                120                125
Val Ser Ile Val Gln Ser Val Asn Tyr Ser Lys Val Leu Ser Val Leu 
     130                135                140
Val Trp Val Leu Met Leu Leu Leu Ala Val Pro Asn Ile Ile Leu Thr 
 145                150                155                160
Asn Gln Ser Val Lys Asp Val Thr Asn Ile Gln Cys Met Glu Leu Lys 
                 165                170                175
Asn Glu Leu Gly Arg Lys Trp His Lys Ala Ser Asn Tyr Val Phe Val 
             180                185                190
Ser Ile Phe Trp Ile Val Phe Leu Leu Leu Thr Val Phe Tyr Met Ala 
         195                200                205
Ile Thr Arg Lys Ile Phe Lys Ser His Leu Lys Ser Arg Lys Asn Ser 
     210                215                220
Ile Ser Val Lys Arg Lys Ser Ser Arg Asn Ile Phe Ser Ile Val Leu 
 225                230                235                240
Ala Phe Val Ala Cys Phe Ala Pro Tyr His Val Ala Arg Ile Pro Tyr 
                 245                250                255
Thr Lys Ser Gln Thr Glu Gly His Tyr Ser Cys Gln Ala Lys Glu Thr 
             260                265                270
Leu Leu Tyr Thr Lys Glu Phe Thr Leu Leu Leu Ser Ala Ala Asn Val 
         275                280                285
Cys Leu Asp Pro Ile Ser Ile Ser Ser Tyr Ala Ser Arg Leu Glu Lys 
     290                295                300
Ser 
 305



<210> 8909
<211> 2416
<212> DNA
<213> Homo sapiens
<308> D13626
<400> 8909

gaacagtgt  accttggag  ctacaatga  aggtatttc  aaatgagtg  agcatgact  60
tcacagatg  aggcctaga  gcaggatct  taatggaaa  acacttggg  cacttcaag  120
cgacaaacg  tcactgggc  aaacacctt  actgaaaag  gacctcata  tatgcaaaa  180
aaatcttaa  aggcctctg  cttcagaag  tacaagatg  tcaattcaa  ctccacaca  240
cctccagat  aatcctgct  tcagaacct  ctgatcact  agcagatca  tcctgtgct  300
tactgtatg  tcttcattg  gggaatcct  ctcaatgga  tgtcaggat  gatattctt  360
tacgtgccc  gctctaaga  tttcatcat  tatctcaag  acattgtta  tgctgactt  420
gtgatgagc  tgacttttc  tttcaagat  cttggtgac  caggccttg  tccctggca  480
ctgaacgtg  ttgtgtgca  ggtctctgc  gtgctcttc  acgtcaaca  gtacgtcag  540
attgtgttc  ttgggctca  cagctttga  aggtattat  aaattgtaa  gcctctttg  600
acttctttc  tccagtcag  gagttacag  aaacttctg  cagtgatag  atggatgct  660
atgctcctc  ttgctgttc  aaatattat  ctcaccaac  agagtgtta  ggaggttac  720
caaataaaa  gtatagaac  gaaaagtga  ctgggacgg  agtggcaca  agcatcaaa  780
tacatcttc  tggccatct  ctggattgt  tttcttttg  taatcgttt  ctatactgc  840
atcacaaag  aaatcttta  gtcccacct  aagtcaagt  ggaattcca  ttcggtcaa  900
aagaaatct  gccgcaaca  attcagcat  gtgtttgtg  tttttgtct  ttttgtacc  960
taccatatt  ccagaatcc  ctacacaaa  agtcagacc  aagctcatt  cagctgcca  1020
tcaaaagaa  tcttgcggt  tatgaaaga  ttcactctg  tactatctg  tgcaaatgt  1080
tgcttggac  ctattattt  tttctttct  tgccagccg  ttagggaaa  cttatgtaa  1140
aaattgcac  ttccattaa  agctcagaa  gacctagac  tttccagaa  caaaagagg  1200
aatacaaca  ttgaaagca  agatacttt  tgagttcct  ccctcttcc  aagaaagac  1260
acgtgtgca  gttgtcatc  tcaattaca  aacagaaat  aataagata  gtgccctca  1320
cataaatat  atctctagc  ctgccatcc  atttagttc  ataaaattc  aatataagt  1380
tccatgctt  tttgtaaca  caaagaaaa  atacccatc  gtaatttct  taatactga  1440
ctttctatt  tctattaat  aaaaattaa  acatacaat  attcaattc  attatatta  1500
aataagtta  agtttataa  cactagtct  gtcagttaa  gtagaaatt  aaatagtaa  1560
taaaacaca  cataatcaa  gacaactca  tcaggcatc  tctttctct  aataccaga  1620
tctagtatg  aattgtttt  aacactgtc  ttaaagact  acttgaaag  aggcacagt  1680
tgatgaagg  ctagagagc  gtttgcaat  aaaagtcag  tttttttcc  gatttgaag  1740
agcaggaaa  gctgacacc  agacaatca  ttaagaaac  ccttattga  gtatttcat  1800
gcactgcaa  ggaagagga  tattaattg  atacttagc  agaaaattt  ttttttctg  1860
tagcacttt  aggatatta  atacatgct  aatatgttt  ctacaaaga  ttacgtcat  1920
taatgagcc  ggggttctg  tgttagaat  tttttaagt  ggctttact  agagaaact  1980
aatattggc  tacgttatc  gcaacttcc  ctgttcaat  gtatgggaa  aataagatg  2040
ctgggaaaa  gacacaccc  caccgtaga  catatatta  tctactggc  aatgggaaa  2100
gagaccatt  tcttagaaa  caaataaac  tgatttttt  aaatctaaa  tttacatta  2160
tgagtgcaa  ataacacat  aaatgaaaa  tcacacatc  catttttct  gaaaacaga  2220
ggattttac  tctggagac  tggcatacg  ttactgact  atgagctac  aaaactaaa  2280
tctttctct  ctattaact  gctagaaga  attcatcta  ttttcaaat  ttctttcaa  2340
acattttta  aagtaatgt  tgtatctat  tcatgcttt  ctgtctata  actaataaa  2400
aaatgtttt  atactg  2416



<210> 8910
<211> 338
<212> PRT
<213> Homo sapiens
<308> Q15391
<400> 8910

Met Ile Asn Ser Thr Ser Thr Gln Pro Pro Asp Glu Ser Cys Ser Gln 
  1               5                  10                  15
Asn Leu Leu Ile Thr Gln Gln Ile Ile Pro Val Leu Tyr Cys Met Val 
             20                  25                  30
Phe Ile Ala Gly Ile Leu Leu Asn Gly Val Ser Gly Trp Ile Phe Phe 
         35                  40                  45
Tyr Val Pro Ser Ser Lys Ser Phe Ile Ile Tyr Leu Lys Asn Ile Val 
     50                  55                  60
Ile Ala Asp Phe Val Met Ser Leu Thr Phe Pro Phe Lys Ile Leu Gly 
 65                  70                  75                  80
Asp Ser Gly Leu Gly Pro Trp Gln Leu Asn Val Phe Val Cys Arg Val 
                 85                  90                  95
Ser Ala Val Leu Phe Tyr Val Asn Met Tyr Val Ser Ile Val Phe Phe 
             100                105                110
Gly Leu Ile Ser Phe Asp Arg Tyr Tyr Lys Ile Val Lys Pro Leu Trp 
         115                120                125
Thr Ser Phe Ile Gln Ser Val Ser Tyr Ser Lys Leu Leu Ser Val Ile 
     130                135                140
Val Trp Met Leu Met Leu Leu Leu Ala Val Pro Asn Ile Ile Leu Thr 
 145                150                155                160
Asn Gln Ser Val Arg Glu Val Thr Gln Ile Lys Cys Ile Glu Leu Lys 
                 165                170                175
Ser Glu Leu Gly Arg Lys Trp His Lys Ala Ser Asn Tyr Ile Phe Val 
             180                185                190
Ala Ile Phe Trp Ile Val Phe Leu Leu Leu Ile Val Phe Tyr Thr Ala 
         195                200                205
Ile Thr Lys Lys Ile Phe Lys Ser His Leu Lys Ser Ser Arg Asn Ser 
     210                215                220
Thr Ser Val Lys Lys Lys Ser Ser Arg Asn Ile Phe Ser Ile Val Phe 
 225                230                235                240
Val Phe Phe Val Cys Phe Val Pro Tyr His Ile Ala Arg Ile Pro Tyr 
                 245                250                255
Thr Lys Ser Gln Thr Glu Ala His Tyr Ser Cys Gln Ser Lys Glu Ile 
             260                265                270
Leu Arg Tyr Met Lys Glu Phe Thr Leu Leu Leu Ser Ala Ala Asn Val 
         275                280                285
Cys Leu Asp Pro Ile Ile Tyr Phe Phe Leu Cys Gln Pro Phe Arg Glu 
     290                295                300
Ile Leu Cys Lys Lys Leu His Ile Pro Leu Lys Ala Gln Asn Asp Leu 
 305                310                315                320
Asp Ile Ser Arg Ile Lys Arg Gly Asn Thr Thr Leu Glu Ser Thr Asp 
                 325                330                335
Thr Leu 
             340



<210> 8911
<211> 1719
<212> DNA
<213> Rattus norvegicus
<308> U76252
<400> 8911

atggcatgg  gccatagga  cacagtctg  ctggtcctg  tgggtgtga  tctgggtct  60
gccatcatt  tgctggctg  ggtccttcc  catcaccaa  cctcttgcc  tcccgatgc  120
ttcactcgt  ctgccgtag  tgctgactc  aagatctgc  cagatattg  acgagtcat  180
ctccagcag  agggctcac  tgtggacgc  gccattgct  ccctcatct  taccggtgt  240
gttaaccct  agagcatgg  cctgggcgg  ggggtcgtc  tcaccatct  caatgcatc  300
acagggaag  tggaggtca  caatgctcg  gagacagtg  cagccagcc  tgaccagag  360
ctgctagac  agtgtacaa  tgccctgcc  ctgtgcaca  gggcccagt  gatcggggt  420
cctggtgag  tccgcggct  tgctgaggc  caccgccga  acggccgcc  gccttgggc  480
cagcttttc  agcccacca  tgccctgct  cgagagggt  tccgtgtgc  ccctatcct  540
agtcagttc  tcaacacca  cttcctgca  ccctgcttg  attcatcaa  cctgagaca  600
ctcttcttc  atgggacag  aaccttgag  tctcaggac  cactcccat  gcctgcgct  660
gccaacacc  tggagactg  ggctaagga  ggtgcagag  tcttataca  cggaaagct  720
ggacaaacg  tggtggaag  cattgcctg  caaggaagc  agctgacgg  tcaggactt  780
gctgccttc  ggccgaaag  ggtggaacc  ctggagatg  ccctaggaa  ctataccct  840
tactctcca  cgccgcctg  agggggcgc  attcttagc  tcattctca  cgtgctgaa  900
gggttcaac  tttctgcag  gacggtggc  gggcctgaa  ggaaggtga  catgtacca  960
caccttgta  agacgctca  gttcgcagt  gggcagagg  ggcggctat  ggaccccta  1020
agccaccca  ggatacaga  catctccca  gaccttctc  gggagactc  agcccagca  1080
atccgccag  agattgatg  ccgtggtga  caccagctc  gccattaca  cctgtccgg  1140
gtcaggggc  acagcatgg  cacgtctca  gtgtctgtg  tgggagaag  cggcagcgc  1200
gtggcagcc  ccagcacca  caacacacc  tttggagcg  tggtgtact  cccacggac  1260
ggcatcctc  tcaacaacg  gctactaga  ttatgctgg  gacacaagc  aggttcaac  1320
gtcacccct  cccctgttc  aggtgagca  ccaccatca  ccatggtac  ctccatctt  1380
atcaacgaa  tccaggggt  gaagctggt  atcggtggg  ctggtgggg  gcttatcat  1440
tctgctgtg  cccaggcta  cgtgaataa  ctgtggctt  gctttagcc  gacagacgc  1500
atcgcagcg  ccatcctac  tgtgaatag  aagggccac  tggaatatg  gcccaagtt  1560
aaccaggag  ttcggaagg  gctacagga  cgaggccag  gccagagcc  gagccagag  1620
ccggttttc  tgaattcgg  ccaggctgt  tttcaggaa  ggccctgtg  ctatgcagc  1680
tctgacctg  ggaaggctg  aaaggcttc  ggatactaa  1719



<210> 8912
<211> 568
<212> PRT
<213> Rattus norvegicus
<308> P07314
<400> 8912

Met Lys Asn Arg Phe Leu Val Leu Gly Leu Val Ala Val Val Leu Val 
  1               5                  10                  15
Phe Val Ile Ile Gly Leu Cys Ile Trp Leu Pro Thr Thr Ser Gly Lys 
             20                  25                  30
Pro Asp His Val Tyr Ser Lys Ala Ala Val Ala Thr Asp Ala Lys Arg 
         35                  40                  45
Cys Ser Glu Ile Gly Arg Asp Met Leu Gln Glu Gly Gly Ser Val Val 
     50                  55                  60
Asp Ala Ala Ile Ala Ser Leu Leu Cys Met Gly Leu Ile Asn Ala His 
 65                  70                  75                  80
Ser Met Gly Ile Gly Gly Gly Leu Phe Phe Thr Ile Tyr Asn Ser Thr 
                 85                  90                  95
Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Met Ala Pro Arg Leu 
             100                105                110
Ala Asn Thr Ser Met Phe Asn Asn Ser Lys Asp Ser Glu Glu Gly Gly 
         115                120                125
Leu Ser Val Ala Val Pro Gly Glu Ile Arg Gly Tyr Glu Leu Ala His 
     130                135                140
Gln Arg His Gly Arg Leu Pro Trp Ala Arg Leu Phe Gln Pro Ser Ile 
 145                150                155                160
Gln Leu Ala Arg His Gly Phe Pro Val Gly Lys Gly Leu Ala Arg Ala 
                 165                170                175
Leu Asp Lys Lys Arg Asp Ile Ile Glu Lys Thr Pro Ala Leu Cys Glu 
             180                185                190
Val Phe Cys Arg Gln Gly Lys Val Leu Gln Glu Gly Glu Thr Val Thr 
         195                200                205
Met Pro Lys Leu Ala Asp Thr Leu Gln Ile Leu Ala Gln Glu Gly Ala 
     210                215                220
Arg Ala Phe Tyr Asn Gly Ser Leu Thr Ala Gln Ile Val Lys Asp Ile 
 225                230                235                240
Gln Glu Ala Gly Gly Ile Met Thr Val Glu Asp Leu Asn Asn Tyr Arg 
                 245                250                255
Ala Glu Val Ile Glu His Pro Met Ser Ile Gly Leu Gly Asp Ser Thr 
             260                265                270
Leu Tyr Val Pro Ser Ala Pro Leu Ser Gly Pro Val Leu Ile Leu Ile 
         275                280                285
Leu Asn Ile Leu Lys Gly Tyr Asn Phe Ser Pro Lys Ser Val Ala Thr 
     290                295                300
Pro Glu Gln Lys Ala Leu Thr Tyr His Arg Ile Val Glu Ala Phe Arg 
 305                310                315                320
Phe Ala Tyr Ala Lys Arg Thr Met Leu Gly Asp Pro Lys Phe Val Asp 
                 325                330                335
Val Ser Gln Val Ile Arg Asn Met Ser Ser Glu Phe Tyr Ala Thr Gln 
             340                345                350
Leu Arg Ala Arg Ile Thr Asp Glu Thr Thr His Pro Thr Ala Tyr Tyr 
         355                360                365
Glu Ala Glu Phe Tyr Leu Pro Asp Asp Gly Gly Thr Ala His Leu Ser 
     370                375                380
Val Val Ser Glu Asp Gly Ser Ala Val Ala Ala Thr Ser Thr Ile Asn 
 385                390                395                400
Leu Tyr Phe Gly Ser Lys Val Leu Ser Arg Val Ser Gly Ile Leu Phe 
                 405                410                415
Asn Asp Glu Met Asp Asp Phe Ser Ser Pro Asn Phe Thr Asn Gln Phe 
             420                425                430
Gly Val Ala Pro Ser Pro Ala Asn Phe Ile Lys Pro Gly Lys Gln Pro 
         435                440                445
Leu Ser Ser Met Cys Pro Ser Ile Ile Val Asp Lys Asp Gly Lys Val 
     450                455                460
Arg Met Val Val Gly Ala Ser Gly Gly Thr Gln Ile Thr Thr Ser Val 
 465                470                475                480
Ala Leu Ala Ile Ile Asn Ser Leu Trp Phe Gly Tyr Asp Val Lys Arg 
                 485                490                495
Ala Val Glu Glu Pro Arg Leu His Asn Gln Leu Leu Pro Asn Thr Thr 
             500                505                510
Thr Val Glu Lys Asn Ile Asp Gln Val Val Thr Ala Gly Leu Lys Thr 
         515                520                525
Arg His His His Thr Glu Val Thr Pro Asp Phe Ile Ala Val Val Gln 
     530                535                540
Ala Val Val Arg Thr Ser Gly Gly Trp Ala Ala Ala Ser Asp Ser Arg 
 545                550                555                560
Lys Gly Gly Glu Pro Ala Gly Tyr 
                 565



<210> 8913
<211> 2444
<212> DNA
<213> Homo sapiens
<308> AL117414
<400> 8913

gggccactc  gtagtgtgc  cttggtgag  gcagcagct  gccacagct  ccagccatc  60
gtccattca  ccatctgtc  gtctggcag  ccgctgttc  gacctgtct  tctgtccgc  120
catctgtaa  cccatctct  tcccattgt  tatctgacc  tctttctct  actgtcctc  180
ttgtctagc  atctggcct  tctgtcgat  catcttcgt  tctgtcttc  gcccccacc  240
gtttgtcca  ctgtccaat  acctgtgac  ctgtgcatc  tcttgtcca  tcatctgcc  300
acccatccg  ccctccgtc  gcccaccag  cgcccctct  ctcctgggc  gcagagcca  360
ggcccgggg  tacggggcc  cggtcagcc  agtcctgct  ggtctgggg  tggcgctgg  420
tgtcattgt  ctggctgtg  tcctctctc  acaccaggc  ccatgtggc  cccaggcct  480
tgcccacgc  gctgttgcc  ccgactcca  ggtctgctc  gatattgga  gagccatcc  540
ccagcagca  ggctcaccc  tggatgcca  catcgcggc  ctggtctgc  ccagcgtcg  600
caaccctca  agcatgggc  tgggcggag  ggtcatctt  accatctac  atgtgacaa  660
aggggccca  tggatcggg  tgcccgggg  gctccgtgg  tatgccgag  cccaccgcc  720
ccatggccg  ctgccctgg  cgcagctgt  ccagcccac  atcgcgctg  tccgagggg  780
gcatgtggt  gcccctgtc  tcagccgtt  cctgcacaa  agcatcctg  ggccttcct  840
gcaggcgtc  accctgcgc  agctcttct  caacgggac  gaacccctg  ggcctcagg  900
cccactccc  tggcctgca  tggccacca  cctggagac  gtggccaca  agggcgtgg  960
ggtcttcta  acggggagg  tgggccaga  gctggtgga  gacattgcc  aggaaggga  1020
ccagctgac  ctgcaggac  tggccaagt  ccagcccga  gtggtggat  ccctggagg  1080
gcccctggg  gactatacc  tgtactcac  accgccgcc  gcagggggt  ccattctca  1140
ctttatcct  aacgtgcta  gagggttca  cttctcaac  gagtctatg  ccaggcctg  1200
agggagggt  aacgtgtac  accaccttg  agagacgct  aagtttgcc  aggggcaga  1260
gtggaggct  ggggaccct  gaagccacc  gaagctcca  aatgcctcc  gggacctgc  1320
gggggagac  ctggcccag  tcatccgcc  acagatcga  ggccggggg  accaccagc  1380
cagccacta  agcttggcc  aggcctggg  ccacgggac  ggcacgtcc  atgtgtcag  1440
gctggggga  gatggcagc  ccgtggctg  caccagcac  atctacaca  cctttggag  1500
gatggtgta  tcaccacgg  caggcatca  cctcaacaa  gagctcctg  acttatgcg  1560
gcgatgccc  cggggttcc  gcaccaccc  ctcacctgt  agggagaca  ggtgggtgg  1620
gctcccgga  ggtgctggc  cccagttcc  ggcgagcgt  ccccatcct  catggtgcc  1680
tccatcttg  tcaacaaag  ccaggggtc  aagctagtg  ttggcgggg  tggcgggga  1740
ctcatcatc  ctgctgtgg  ccaggccat  atgagcaag  tgtggcttg  ctttgacct  1800
agagcggcc  ttgcagccc  catcctgca  gtcaacagc  agggctgtg  ggagtacga  1860
cccaacttc  gccagagac  gtgtcttgc  ttgttgccc  ggctgttct  aaactcctg  1920
cctcaagtg  tcctgccac  ttggctccc  agtggctaa  actgtagga  gtgcagagg  1980
gactccaag  ccgtggcca  aaccagacc  agaggccct  cttcctgaa  gtggtccag  2040
ctgtgtccc  ggagggggc  tgtgtgtac  ccgtctcgg  cctgaggaa  agtggggag  2100
ccgcaggct  ctaagacac  gctctgccc  gagctgaag  ctggcccca  catgagtcc  2160
gtgtccagg  cggacatgg  tgggggacc  actactctg  caggatctg  acccctggc  2220
ggggagtcc  gctgagagt  gaagaggtg  cggggacca  ctgggcaga  gagaggctg  2280
gcctcatcc  taaccccct  tcccagagc  cctggtggt  ctgaaccgg  ccctctatc  2340
ctccgcagg  ctcttgcct  gggccactc  cccaccctc  cgatctgta  atcctccag  2400
ccaagatta  agaggcgga  tatgaaaaa  aaaaaaaaa  aaac  2444



<210> 8914
<211> 586
<212> PRT
<213> Homo sapiens
<308> P36269
<400> 8914

Met Ala Arg Gly Tyr Gly Ala Thr Val Ser Leu Val Leu Leu Gly Leu 
  1               5                  10                  15
Gly Leu Ala Leu Ala Val Ile Val Leu Ala Val Val Leu Ser Arg His 
             20                  25                  30
Gln Ala Pro Cys Gly Pro Gln Ala Phe Ala His Ala Ala Val Ala Ala 
         35                  40                  45
Asp Ser Lys Val Cys Ser Asp Ile Gly Arg Ala Ile Leu Gln Gln Gln 
     50                  55                  60
Gly Ser Pro Val Asp Ala Thr Ile Ala Ala Leu Val Cys Thr Ser Val 
 65                  70                  75                  80
Val Asn Pro Gln Ser Met Gly Leu Gly Gly Gly Val Ile Phe Thr Ile 
                 85                  90                  95
Tyr Asn Val Thr Thr Gly Lys Val Glu Val Ile Asn Ala Arg Glu Thr 
             100                105                110
Val Pro Ala Ser His Ala Pro Ser Leu Leu Asp Gln Cys Ala Gln Ala 
         115                120                125
Leu Pro Leu Gly Thr Gly Ala Gln Trp Ile Gly Val Pro Gly Glu Leu 
     130                135                140
Arg Gly Tyr Ala Glu Ala His Arg Arg His Gly Arg Leu Pro Trp Ala 
 145                150                155                160
Gln Leu Phe Gln Pro Thr Ile Ala Leu Leu Arg Gly Gly His Val Val 
                 165                170                175
Ala Pro Val Leu Ser Arg Phe Leu His Asn Ser Ile Leu Arg Pro Ser 
             180                185                190
Leu Gln Ala Ser Thr Leu Arg Gln Leu Phe Phe Asn Gly Thr Glu Pro 
         195                200                205
Leu Arg Pro Gln Asp Pro Leu Pro Trp Pro Ala Leu Ala Thr Thr Leu 
     210                215                220
Glu Thr Val Ala Thr Glu Gly Val Glu Val Phe Tyr Thr Gly Arg Leu 
 225                230                235                240
Gly Gln Met Leu Val Glu Asp Ile Ala Lys Glu Gly Ser Gln Leu Thr 
                 245                250                255
Leu Gln Asp Leu Ala Lys Phe Gln Pro Glu Val Val Asp Ala Leu Glu 
             260                265                270
Val Pro Leu Gly Asp Tyr Thr Leu Tyr Ser Pro Pro Pro Pro Ala Gly 
         275                280                285
Gly Ala Ile Leu Ser Phe Ile Leu Asn Val Leu Arg Gly Phe Asn Phe 
     290                295                300
Ser Thr Glu Ser Met Ala Arg Pro Glu Gly Arg Val Asn Val Tyr His 
 305                310                315                320
His Leu Val Glu Thr Leu Lys Phe Ala Arg Gly Gln Arg Trp Arg Leu 
                 325                330                335
Gly Asp Pro Arg Ser His Pro Lys Leu Gln Asn Ala Ser Arg Asp Leu 
             340                345                350
Leu Gly Glu Thr Leu Ala Gln Leu Ile Arg Gln Gln Ile Asp Gly Arg 
         355                360                365
Gly Asp His Gln Leu Ser His Tyr Ser Leu Ala Glu Ala Trp Gly His 
     370                375                380
Gly Thr Gly Thr Ser His Val Ser Val Leu Gly Glu Asp Gly Ser Ala 
 385                390                395                400
Val Ala Ala Thr Ser Thr Ile Asn Thr Pro Phe Gly Ala Met Val Tyr 
                 405                410                415
Ser Pro Arg Thr Gly Ile Ile Leu Asn Asn Glu Leu Leu Asp Leu Cys 
             420                425                430
Glu Arg Cys Pro Trp Gly Ser Gly Thr Thr Pro Ser Pro Val Ser Gly 
         435                440                445
Asp Arg Val Gly Gly Ala Pro Gly Arg Cys Trp Pro Pro Val Pro Gly 
     450                455                460
Glu Arg Ser Pro Ser Ser Met Val Pro Ser Ile Leu Ile Asn Lys Ala 
 465                470                475                480
Gln Gly Ser Lys Leu Val Ile Gly Gly Ala Gly Gly Glu Leu Ile Ile 
                 485                490                495
Ser Ala Val Ala Gln Ala Ile Met Ser Lys Leu Trp Leu Gly Phe Asp 
             500                505                510
Leu Arg Ala Ala Ile Ala Ala Pro Ile Leu His Val Asn Ser Lys Gly 
         515                520                525
Cys Val Glu Tyr Glu Pro Asn Phe Ser Gln Glu Val Gln Arg Gly Leu 
     530                535                540
Gln Asp Arg Gly Gln Asn Gln Thr Gln Arg Pro Phe Phe Leu Asn Val 
 545                550                555                560
Val Gln Ala Val Ser Gln Glu Gly Ala Cys Val Tyr Ala Val Ser Asp 
                 565                570                575
Leu Arg Lys Ser Gly Glu Ala Ala Gly Tyr 
             580                585



<210> 8915
<211> 4039
<212> DNA
<213> Rattus norvegicus
<308> U76557
<400> 8915

agcatacac  gctgtgcat  tacttcaac  tgctttcta  aagaatctt  tatcgtagg  60
tcatatttt  caacaaaaa  tccttgaac  aactgtaca  tcagagccg  cttcccaac  120
cctcctgag  caagaacga  tagcttata  tcacgcatg  tgcacactt  ttacactta  180
tacctctcg  gctgtgttg  ttcggtcga  gagccgtcg  cgccatttc  agacagtgc  240
agaaacatt  ttgttagta  tggcggcag  agaagtcaa  tatcccctt  ttctatctc  300
agaagctcc  gatggcgtc  tccgtgggc  acgtggccg  cagcacagg  ttagctgag  360
tggcacatc  ggaatatca  gcaggagac  ttgaggcag  tgagagaca  tgcatgcag  420
tctggagac  agagcctga  aatactggt  ttcttttat  actttcatc  atacatttc  480
agtgtcgaa  gctggacag  tctgctcac  ttagcacct  ggcaattaa  cagaatccc  540
ttctagcag  agcctattc  aatttggga  atgtataca  ggaaagagg  caattacag  600
aagcaattg  gcattatcg  catgctttg  ggctcaagc  tgatttcat  gatggttat  660
ttaacctgg  agcagcctt  gtagcagca  gtgacatgg  gggagcagt  caagcatac  720
tctctgctc  tcagtacaa  cctgatttg  actgtgttc  cagtgacct  gggaacctg  780
tcaaagccc  gggtcgctt  gaagaagcc  aggcatgtt  tttgaaagc  attgagacg  840
aaccaaact  tgctgtagc  tggagtaat  tcggctgtg  tttcaatgc  caaggggag  900
tttggctgg  aattcatca  tttgaaaag  ctgtcaccc  tgacccaaa  tttctggat  960
cttatatca  tttaggaaa  gttttgaaa  aggcacgga  ttttgacag  gctgtggca  1020
cttatcttc  tgccttaag  ttgagccca  atcatgcgg  ggtacacgg  aacctggct  1080
gtgtgtact  tgagcaagg  cttatagac  tggccattg  tacctacag  cgagctata  1140
aactgcagc  tcatttccc  gatgcatac  gcaacctag  aaatgctct  aaagagaag  1200
gcagtgttg  tgaagcaga  gattgttat  acacagctc  tcgtctgtg  cctacccat  1260
cagactctt  gaataacct  gccaacatc  aacgggaac  gggcaatat  gaagaggca  1320
ttcgcctgt  tcgcaaagc  ttagaggtc  tcccagagt  tgctgctgc  cattccaat  1380
tagcaagtg  actgcaaca  cagggcaag  tgcaggaag  actgatgca  tataaggaa  1440
ccataagaa  cagtcctac  tttgctgat  cttattcca  tatgggaaa  actttaaag  1500
agatgcagg  tgttcaggg  gctttgcag  gttatactc  tgccatcca  attaatcct  1560
ccttcgcag  tgcacacag  aatctggct  ccattcaca  ggattcagg  aatattcca  1620
aagcaatag  ttcttaccg  acagctctg  aacttaagc  tgactttcc  gatgcttat  1680
gtaacttgg  tcattgcct  cagattgtc  gtgattgga  agactatga  gagcggatg  1740
agaaattgg  tagtattgt  gctgagcag  tagagaaga  taggctgcc  tctgtccat  1800
ctcatcaca  catgctgta  cctctttcc  atggcttca  gaaggccat  gcagagagg  1860
atgggaatc  ctgcttgga  aagattaat  tccttcata  accaccata  gagcatcca  1920
aagacttga  gctcagtga  ggccgattg  gtgtaggct  tgtgagttc  gactttggg  1980
atcatccta  ttcacacct  atgcagtct  ttccaggca  gcacaaccc  gataagttt  2040
aggtattct  ctatgcctt  agcccggat  acggtacaa  cttccgagt  aaggtgatg  2100
cggaagcca  tcacttcat  gatctttct  agattccgt  caatggaaa  gcagctgac  2160
gcatccacc  agatggaat  cacatcctt  tcaatatga  tgggtacac  aagggtgcc  2220
gaaatgagc  ctttgctct  aggccagct  ctattcagg  tatgtggct  ggctaccct  2280
ggactagtg  cgcactgtt  atggattac  tcatcactg  tcaggaaac  tccccagct  2340
aagttgcag  gcagtattc  gaaaaactg  cttatatgc  ccatacgtt  tttattggt  2400
atcatgcta  tatgttccc  cacctgaag  aaaaagcag  catcgattt  aaatctaat  2460
ggcacattt  tgacaatcg  atagttttg  atggcatcg  tctcaaagc  tttctcgat  2520
gtctacccg  tgtgaagat  gtcaagatg  aatgtcctg  tggaggtga  aatgcagac  2580
ccactaaca  agctcttaa  atgcccgtt  ttcccatga  tacgattgc  gaagcagta  2640
ttgaaatga  taacagagg  cagattcag  taacaatta  tggattcag  attagcaat  2700
gactggcta  tacacagat  aataacaag  ctgcaactg  agaggaagt  ccccgtacc  2760
ttattgtaa  cacccgttc  cagtacggg  taccagaag  tgccattgt  tactgtaac  2820
ttaatcagt  atataaaat  gacccttct  ccctgcaga  gggggcaaa  attctgaaa  2880
gtgtgccta  tagcgtgct  tggctgttg  gttttccag  agtaggaga  cccaatatt  2940
aacaatatg  acaaaatat  ggccttccc  agaaccgta  cattttctc  cctgtggct  3000
ctaaagagg  gcatgtcag  agaggtcag  tggctgatg  ctgcctgga  actcctttg  3060
gtaatggac  taccacagg  atggatgtt  tctgggcag  aacacccat  gtgactatg  3120
caggagaga  tcttgcctc  cgagttgca  cttctcagc  cacttgtct  ggatgtctt  3180
agctcattg  taaaagcag  caggaatat  aagacatag  cgtgaaact  gggaccgat  3240
tagaatacc  gaagaaaat  cgtggcaaa  tatggaaac  gagaatatc  agccctctg  3300
tcaacacca  acaatacac  atggaatta  agcggctgt  tctgcagat  tgggagcat  3360
atgcagctg  caacaaacc  gaccacatg  ttaagcctg  tgaagtcac  gagtcagcc  3420
gaataaaga  tgcgcacag  agaattgcc  ctatacctg  gcctcaacc  tctggggga  3480
agggaacta  ataacatgc  ttatgctta  ctgtatagt  ctgtgttgc  gatgggtga  3540
atataatga  aatagaata  cacagccag  cttgcttcc  gcatgatag  gagagacaa  3600
aaataagaa  ctactattc  acaaggaat  tctagagtt  tgcagcaaa  aggtdgtgc  3660
caggdctgg  atgtttgct  tcctttrgt  ttccatgga  gcttaatgt  gagggagat  3720
gagattaac  agccatttt  tgattccgt  gattgatca  atcttctga  cctttattt  3780
tttctttat  ttatggggt  tgaagcttt  aaaaatgtt  gctttcagg  atttttttt  3840
catgtgaag  gatcttgat  cttctgaga  gaggtttta  actaaaatg  tgcttcctg  3900
tttagtgtc  gaactctga  agggtgaca  ggaccttgc  ggtgtaatc  ttttatagg  3960
tttataaac  acatgagcc  atatcagtc  ttttagtgt  tgacctaat  cttggcact  4020
tcagtgctt  gtgtaaatg  4039



<210> 8916
<211> 1036
<212> PRT
<213> Rattus norvegicus
<308> P56558
<400> 8916

Met Ala Ser Ser Val Gly Asn Val Ala Asp Ser Thr Gly Leu Ala Glu 
  1               5                  10                  15
Leu Ala His Arg Glu Tyr Gln Ala Gly Asp Phe Glu Ala Ala Glu Arg 
             20                  25                  30
His Cys Met Gln Leu Trp Arg Gln Glu Pro Asp Asn Thr Gly Val Leu 
         35                  40                  45
Leu Leu Leu Ser Ser Ile His Phe Gln Cys Arg Arg Leu Asp Arg Ser 
     50                  55                  60
Ala His Phe Ser Thr Leu Ala Ile Lys Gln Asn Pro Leu Leu Ala Glu 
 65                  70                  75                  80
Ala Tyr Ser Asn Leu Gly Asn Val Tyr Lys Glu Arg Gly Gln Leu Gln 
                 85                  90                  95
Glu Ala Ile Glu His Tyr Arg His Ala Leu Arg Leu Lys Pro Asp Phe 
             100                105                110
Ile Asp Gly Tyr Ile Asn Leu Ala Ala Ala Leu Val Ala Ala Gly Asp 
         115                120                125
Met Glu Gly Ala Val Gln Ala Tyr Val Ser Ala Leu Gln Tyr Asn Pro 
     130                135                140
Asp Leu Tyr Cys Val Arg Ser Asp Leu Gly Asn Leu Leu Lys Ala Leu 
 145                150                155                160
Gly Arg Leu Glu Glu Ala Lys Ala Cys Tyr Leu Lys Ala Ile Glu Thr 
                 165                170                175
Gln Pro Asn Phe Ala Val Ala Trp Ser Asn Leu Gly Cys Val Phe Asn 
             180                185                190
Ala Gln Gly Glu Ile Trp Leu Ala Ile His His Phe Glu Lys Ala Val 
         195                200                205
Thr Leu Asp Pro Asn Phe Leu Asp Ala Tyr Ile Asn Leu Gly Asn Val 
     210                215                220
Leu Lys Glu Ala Arg Ile Phe Asp Arg Ala Val Ala Ala Tyr Leu Arg 
 225                230                235                240
Ala Leu Ser Leu Ser Pro Asn His Ala Val Val His Gly Asn Leu Ala 
                 245                250                255
Cys Val Tyr Tyr Glu Gln Gly Leu Ile Asp Leu Ala Ile Asp Thr Tyr 
             260                265                270
Arg Arg Ala Ile Glu Leu Gln Pro His Phe Pro Asp Ala Tyr Cys Asn 
         275                280                285
Leu Ala Asn Ala Leu Lys Glu Lys Gly Ser Val Ala Glu Ala Glu Asp 
     290                295                300
Cys Tyr Asn Thr Ala Leu Arg Leu Cys Pro Thr His Ala Asp Ser Leu 
 305                310                315                320
Asn Asn Leu Ala Asn Ile Lys Arg Glu Gln Gly Asn Ile Glu Glu Ala 
                 325                330                335
Val Arg Leu Tyr Arg Lys Ala Leu Glu Val Phe Pro Glu Phe Ala Ala 
             340                345                350
Ala His Ser Asn Leu Ala Ser Val Leu Gln Gln Gln Gly Lys Leu Gln 
         355                360                365
Glu Ala Leu Met His Tyr Lys Glu Ala Ile Arg Ile Ser Pro Thr Phe 
     370                375                380
Ala Asp Ala Tyr Ser Asn Met Gly Asn Thr Leu Lys Glu Met Gln Asp 
 385                390                395                400
Val Gln Gly Ala Leu Gln Cys Tyr Thr Arg Ala Ile Gln Ile Asn Pro 
                 405                410                415
Ala Phe Ala Asp Ala His Ser Asn Leu Ala Ser Ile His Lys Asp Ser 
             420                425                430
Gly Asn Ile Pro Glu Ala Ile Ala Ser Tyr Arg Thr Ala Leu Lys Leu 
         435                440                445
Lys Pro Asp Phe Pro Asp Ala Tyr Cys Asn Leu Ala His Cys Leu Gln 
     450                455                460
Ile Val Cys Asp Trp Thr Asp Tyr Asp Glu Arg Met Lys Lys Leu Val 
 465                470                475                480
Ser Ile Val Ala Glu Gln Leu Glu Lys Asn Arg Leu Pro Ser Val His 
                 485                490                495
Pro His His Ser Met Leu Tyr Pro Leu Ser His Gly Phe Arg Lys Ala 
             500                505                510
Ile Ala Glu Arg His Gly Asn Leu Cys Leu Asp Lys Ile Asn Val Leu 
         515                520                525
His Lys Pro Pro Tyr Glu His Pro Lys Asp Leu Lys Leu Ser Asp Gly 
     530                535                540
Arg Leu Arg Val Gly Tyr Val Ser Ser Asp Phe Gly Asn His Pro Thr 
 545                550                555                560
Ser His Leu Met Gln Ser Ile Pro Gly Met His Asn Pro Asp Lys Phe 
                 565                570                575
Glu Val Phe Cys Tyr Ala Leu Ser Pro Asp Asp Gly Thr Asn Phe Arg 
             580                585                590
Val Lys Val Met Ala Glu Ala Asn His Phe Ile Asp Leu Ser Gln Ile 
         595                600                605
Pro Cys Asn Gly Lys Ala Ala Asp Arg Ile His Gln Asp Gly Ile His 
     610                615                620
Ile Leu Val Asn Met Asn Gly Tyr Thr Lys Gly Ala Arg Asn Glu Leu 
 625                630                635                640
Phe Ala Leu Arg Pro Ala Pro Ile Gln Ala Met Trp Leu Gly Tyr Pro 
                 645                650                655
Gly Thr Ser Gly Ala Leu Phe Met Asp Tyr Ile Ile Thr Asp Gln Glu 
             660                665                670
Thr Ser Pro Ala Glu Val Ala Glu Gln Tyr Ser Glu Lys Leu Ala Tyr 
         675                680                685
Met Pro His Thr Phe Phe Ile Gly Asp His Ala Asn Met Phe Pro His 
     690                695                700
Leu Lys Lys Lys Ala Val Ile Asp Phe Lys Ser Asn Gly His Ile Tyr 
 705                710                715                720
Asp Asn Arg Ile Val Leu Asn Gly Ile Asp Leu Lys Ala Phe Leu Asp 
                 725                730                735
Ser Leu Pro Asp Val Lys Ile Val Lys Met Lys Cys Pro Asp Gly Gly 
             740                745                750
Asp Asn Ala Asp Thr Thr Asn Thr Ala Leu Asn Met Pro Val Ile Pro 
         755                760                765
Met Asn Thr Ile Ala Glu Ala Val Ile Glu Met Ile Asn Arg Gly Gln 
     770                775                780
Ile Gln Ile Thr Ile Asn Gly Phe Ser Ile Ser Asn Gly Leu Ala Thr 
 785                790                795                800
Thr Gln Ile Asn Asn Lys Ala Ala Thr Gly Glu Glu Val Pro Arg Thr 
                 805                810                815
Ile Ile Val Thr Thr Arg Ser Gln Tyr Gly Leu Pro Glu Asp Ala Ile 
             820                825                830
Val Tyr Cys Asn Phe Asn Gln Leu Tyr Lys Ile Asp Pro Ser Thr Leu 
         835                840                845
Gln Met Gly Ala Asn Ile Leu Lys Arg Val Pro Asn Ser Val Leu Trp 
     850                855                860
Leu Leu Arg Phe Pro Ala Val Gly Glu Pro Asn Ile Gln Gln Tyr Ala 
 865                870                875                880
Gln Asn Met Gly Leu Pro Gln Asn Arg Ile Ile Phe Ser Pro Val Ala 
                 885                890                895
Pro Lys Glu Glu His Val Arg Arg Gly Gln Leu Ala Asp Val Cys Leu 
             900                905                910
Asp Thr Pro Leu Cys Asn Gly His Thr Thr Gly Met Asp Val Leu Trp 
         915                920                925
Ala Gly Thr Pro Met Val Thr Met Pro Gly Glu Thr Leu Ala Ser Arg 
     930                935                940
Val Ala Ala Ser Gln Leu Thr Cys Leu Gly Cys Leu Glu Leu Ile Ala 
 945                950                955                960
Lys Ser Arg Gln Glu Tyr Glu Asp Ile Ala Val Lys Leu Gly Thr Asp 
                 965                970                975
Leu Glu Tyr Leu Lys Lys Ile Arg Gly Lys Val Trp Lys Gln Arg Ile 
             980                985                990
Ser Ser Pro Leu Phe Asn Thr Lys Gln Tyr Thr Met Glu Leu Glu Arg 
         995                1000                1005
Leu Tyr Leu Gln Met Trp Glu His Tyr Ala Ala Gly Asn Lys Pro Asp 
     1010                1015                1020
His Met Ile Lys Pro Val Glu Val Thr Glu Ser Ala 
 1025                1030                1035



<210> 8917
<211> 2129
<212> DNA
<213> Rattus norvegicus
<308> U76714
<400> 8917

gaggccgct  gagagcagg  ttagggtct  ctgcggccg  tggaccctc  aacccgctt  60
cataaggct  tagctttcc  acttcagct  cagtgttag  taagtttgg  aagaagaca  120
aaagaagac  ccggtgggc  gctttgctg  tctttgcct  agttgtcct  tggggtctt  180
cggcacaag  ctgctgtgc  tatagccgt  ctatctccg  ttcctcaca  tcctgtgaa  240
aagccctgg  caagagcag  taaagctac  agcatccga  caaacaagg  gagagcgtc  300
ggtgccatg  ccaagtcaa  agatcagac  catcaggaa  gatgctgtg  atctttagc  360
aactacctg  cctcagcaa  attcctcct  taccttggc  actctctct  cacttgggg  420
gatcggatg  ggcactttg  agtgtctgt  tttctggtg  aactctacg  aaacagcct  480
ctcttgaca  ctgtctacg  gttggtggt  gcaggctct  ttctggtcc  gggagccat  540
attggtgac  gggtggata  gaatgccag  cttaaagtg  cccagacgt  cctggtggt  600
cagaatgta  cagtcattc  ctgcgggat  atcctgatg  tggttttct  acacaagaa  660
gagcttctg  acatgtatc  tggatgggt  cttactgtc  gctacatcc  gatcatcac  720
attgcaaac  ttgcgaatt  ggccagtac  gccactgca  ttacaatcc  aagggactg  780
attgttgtc  tagcaggag  aaacaggag  agattagca  acatgaatg  taccattag  840
aggattgac  agctaacca  catcctggc  cccatggct  ttggccaga  tatgacatt  900
ggttcccca  tcattggct  tggtttcat  tctggttgg  atttggtgt  catgtgtgt  960
gagtacttc  tgctctgga  ggtttacca  aagacccct  ctctggctg  aaaagctgc  1020
ctcaaggta  aggagtcag  actgaagca  ctgacctca  ctaaagata  ggagccaaa  1080
cctttggag  gaactcacc  aatgggtga  aaagactct  acatccgtg  acttgaatg  1140
gaacaagaa  ccacctgtg  ctcccagat  gcagaaccc  tccgcactt  tcgagatgg  1200
tgggtctcc  actataacc  gcccgtatt  ttgggctgg  atgggcctg  ctttcctct  1260
tatgacagt  ctgggcttc  actgtatcg  cacagtata  gcttacact  agggactga  1320
tggttccat  ctcagtgtt  tgatgggag  atcagcaat  actggaata  tgggaactg  1380
ggccttcac  tggctacgt  gaaaatgtg  ccttgttcg  actggtctg  tctcaggac  1440
ggctcagct  tcttgtttg  tcttgtgtg  gatctccgt  ttcatgcct  gaagcccct  1500
ggacctgtc  gtttctcca  ttgaagata  ccgttctag  tttatacat  aggaggcag  1560
gtcctcaac  accaaaata  ctgaaacgg  aatgcttat  tctaatgtg  ctaatgttg  1620
caataccgt  catgagatg  gtactaaat  cgtccccat  atctccgtc  gcctgctgt  1680
tgcaggagt  attgctgct  gaatcggtc  ttggtcctt  gatttgact  tgacacagt  1740
gctgcaaga  aatgtaatt  aatcagaaa  aggcattat  aatggtgtg  agaactcca  1800
gaactacct  ctcgacctt  tgcatttca  catggtcat  ttggcccca  atcctgaag  1860
ttttggctt  ctagtattg  tttcagtcy  ctttgtggc  atgggacat  ttatgtatt  1920
ccgttttgc  csgaagact  tgggcaacc  gatttttgt  tgtgctcct  atgaaaagg  1980
agttacaga  gaaagtcag  ctaatacat  tgttgtgta  aatagttta  ctgtggccc  2040
tgttactag  tttgtggag  gcatgtgtg  ttattttgt  ctacagaat  ccaataaat  2100
cctgcactt  taaaaaaaa  aaaaaaaaa  2129



<210> 8918
<211> 405
<212> PRT
<213> Rattus norvegicus
<308> AAD00260
<400> 8918

Met Thr Lys Ser Arg Asp Gln Thr His Gln Glu Gly Cys Cys Gly Ser 
  1               5                  10                  15
Leu Ala Asn Tyr Leu Thr Ser Ala Lys Phe Leu Leu Tyr Leu Gly His 
             20                  25                  30
Ser Leu Ser Thr Trp Gly Asp Arg Met Trp His Phe Ala Val Ser Val 
         35                  40                  45
Phe Leu Val Glu Leu Tyr Gly Asn Ser Leu Leu Leu Thr Ala Val Tyr 
     50                  55                  60
Gly Leu Val Val Ala Gly Ser Val Leu Val Leu Gly Ala Ile Ile Gly 
 65                  70                  75                  80
Asp Trp Val Asp Lys Asn Ala Arg Leu Lys Val Ala Gln Thr Ser Leu 
                 85                  90                  95
Val Val Gln Asn Val Ser Val Ile Leu Cys Gly Ile Ile Leu Met Met 
             100                105                110
Val Phe Leu His Lys Asn Glu Leu Leu Asn Met Tyr His Gly Trp Val 
         115                120                125
Leu Thr Val Cys Tyr Ile Leu Ile Ile Thr Ile Ala Asn Ile Ala Asn 
     130                135                140
Leu Ala Ser Thr Ala Thr Ala Ile Thr Ile Gln Arg Asp Trp Ile Val 
 145                150                155                160
Val Val Ala Gly Glu Asn Arg Ser Arg Leu Ala Asp Met Asn Ala Thr 
                 165                170                175
Ile Arg Arg Ile Asp Gln Leu Thr Asn Ile Leu Ala Pro Met Ala Val 
             180                185                190
Gly Gln Ile Met Thr Phe Gly Ser Pro Val Ile Gly Cys Gly Phe Ile 
         195                200                205
Ser Gly Trp Asn Leu Val Ser Met Cys Val Glu Tyr Phe Leu Leu Trp 
     210                215                220
Lys Val Tyr Gln Lys Thr Pro Ala Leu Ala Val Lys Ala Ala Leu Lys 
 225                230                235                240
Val Glu Glu Ser Glu Leu Lys Gln Leu Thr Ser Pro Lys Asp Thr Glu 
                 245                250                255
Pro Lys Pro Leu Glu Gly Thr His Leu Met Gly Glu Lys Asp Ser Asn 
             260                265                270
Ile Arg Glu Leu Glu Cys Glu Gln Glu Pro Thr Cys Ala Ser Gln Ile 
         275                280                285
Ala Glu Pro Phe Arg Thr Phe Arg Asp Gly Trp Val Ser Tyr Tyr Asn 
     290                295                300
Gln Pro Val Phe Leu Gly Trp His Gly Pro Gly Phe Pro Leu Tyr Asp 
 305                310                315                320
Ser Pro Gly Leu Arg Leu Tyr Arg His Ser Ile Cys Leu His Ser Gly 
                 325                330                335
Thr Glu Trp Phe His Pro Gln Cys Phe Asp Gly Ser Ile Ser Asn Asn 
             340                345                350
Trp Asn Asn Gly Asn Cys Gly Leu His Leu Ala Thr Ser Lys Met Trp 
         355                360                365
Pro Cys Ser Asp Trp Ser Val Leu Arg Thr Gly Ser Ala Phe Leu Phe 
     370                375                380
Asp Leu Val Cys Asp Leu Arg Val His Ala Trp Lys Pro Leu Gly Pro 
 385                390                395                400
Val Cys Phe Ser Ile 
                 405



<210> 8919
<211> 2286
<212> DNA
<213> Homo sapiens
<308> AK002038
<400> 8919

cttaaagaa  aggaaactg  attgaaaca  ctgaattta  acaaagata  tgagccaaa  60
cccctggag  gaactcatc  aatgggtgt  aaagactct  acatccatg  gcttgaaca  120
gagcaagag  ctacttgtg  ctcccagat  gctgagccc  tccgtacct  ccgagatgg  180
tgggtctcc  actacaacc  gcctgtgtt  ctggctggc  tgggtcttg  tttccttta  240
atgactgtc  tgggctttg  ctgcatcac  acagggtac  cctacactc  gggactgag  300
ggttccatc  tcagtattt  gatgggagc  tcagctata  ctggaataa  gggaactgt  360
gcttttact  ggctacgtc  aaaatgtgg  ttggttcgg  caggtctga  ctcaggatt  420
gcacagctt  cctgtttga  cttgtgtgt  atctctgta  tcatgcctg  aagccccct  480
gacttgtcc  tttctcctt  tgaagatat  cgatcaagg  tcattcaag  agagtcaat  540
acacctacc  agatacctg  aattacaac  gaaatacat  tctaatggg  ctaattctg  600
taatattgt  ccggagaca  gtcctgaat  tgtgcccat  atctctgtc  gtctgctgt  660
tgcaggcgt  attgctgct  gaatcggtc  ttggtcctt  gatttaact  tgacacagt  720
gctgcaaga  aatgtaatt  aatctgaaa  aggcattat  aatggtgta  agaactcca  780
gaactatct  cttgatctt  tgcatttca  catggtcat  ctggctcca  atcctgaag  840
ttttggctt  ctcgtattg  tttcagtct  ctttgtggc  atgggccac  ttatgtatt  900
ccgatttgc  caaaatact  tgggaaaca  gctctttgc  tgcggtcct  atgcaaaag  960
agttaggaa  gaaaatcaa  caaatacat  tgttgtttg  gacagttta  ctgttgcta  1020
cctgttact  gattatata  agcacatgt  cttattttg  gctgcagaa  tccaataaa  1080
ggctgggtg  tttgctctg  ttttaccac  gctgtgcct  gagaactaa  agctgttta  1140
gaaacctaa  tcagcagaa  ttaactgat  aatttccct  atgttgagg  atggaaaaa  1200
aattggaaa  gaaaaactc  gtttaaata  ggagactat  atgataaca  tgaattccc  1260
tatttctca  gagtagata  aatcttacg  aaaagagtg  ttagtcacg  gaattcagt  1320
atcatttga  agattctta  ctgtactag  attcagata  gtcagtttt  tgcaaaact  1380
actcttgtt  aagactagc  aatttattt  tttgcatct  agttatttt  aaaaacaaa  1440
tcttcaagt  tgaagacta  attttgata  ctaatatta  ccttattga  cctattgat  1500
ttaaggtat  tacatgtat  tggaaaaac  aaacactta  ctagaattc  ctaataagg  1560
ttatggttt  gcttaaaga  cacctttgt  tttttatta  cagatgggg  aacatattg  1620
atgaagcat  tgtagcact  cacagcatg  ttatcatgt  agctgcagg  agaagcaaa  1680
ctgtaaagt  gatttatca  acaatgact  catacagac  tcaaatatg  caatagttt  1740
gtcatagaa  ctagaagcc  aaagccaca  agaagggca  gaatcccaa  ttaactcat  1800
ttatcatca  tagtgatct  tgttgtaga  catgagggt  taagccttc  gcctggcaa  1860
ttacatgta  aaagcccac  cttgtgaag  ttttgtttt  caaatcact  gatttaaca  1920
actcaggta  aatattttt  tttttactg  tttataccc  gaagttatt  ctacattgt  1980
ctacagcaa  aatattcat  aaagtatcc  tttcaaatg  ctttgagaa  aatagaaga  2040
aaaaagttt  tatatattt  aaaaaattg  tttaaaagt  agtttgcaa  atgtctgta  2100
caagatggt  ctttgcctt  accgtttat  tgcactttc  tggagactg  aatacgttg  2160
tatgagcac  ttctttatc  ttggagttt  atcctttgc  tcatctttc  acagtatga  2220
ataatgatt  gctatgttg  aaaatcttt  taaaaaatt  ctatataaa  atattttga  2280
aatctt  2286



<210> 8920
<211> 571
<212> PRT
<213> Homo sapiens
<308> NP_055400
<400> 8920

Met Thr Arg Ala Gly Asp His Asn Arg Gln Arg Gly Cys Cys Gly Ser 
  1               5                  10                  15
Leu Ala Asp Tyr Leu Thr Ser Ala Lys Phe Leu Leu Tyr Leu Gly His 
             20                  25                  30
Ser Leu Ser Thr Trp Gly Asp Arg Met Trp His Phe Ala Val Ser Val 
         35                  40                  45
Phe Leu Val Glu Leu Tyr Gly Asn Ser Leu Leu Leu Thr Ala Val Tyr 
     50                  55                  60
Gly Leu Val Val Ala Gly Ser Val Leu Val Leu Gly Ala Ile Ile Gly 
 65                  70                  75                  80
Asp Trp Val Asp Lys Asn Ala Arg Leu Lys Val Ala Gln Thr Ser Leu 
                 85                  90                  95
Val Val Gln Asn Val Ser Val Ile Leu Cys Gly Ile Ile Leu Met Met 
             100                105                110
Val Phe Leu His Lys His Glu Leu Leu Thr Met Tyr His Gly Trp Val 
         115                120                125
Leu Thr Ser Cys Tyr Ile Leu Ile Ile Thr Ile Ala Asn Ile Ala Asn 
     130                135                140
Leu Ala Ser Thr Ala Thr Ala Ile Thr Ile Gln Arg Asp Trp Ile Val 
 145                150                155                160
Val Val Ala Gly Glu Asp Arg Ser Lys Leu Ala Asn Met Asn Ala Thr 
                 165                170                175
Ile Arg Arg Ile Asp Gln Leu Thr Asn Ile Leu Ala Pro Met Ala Val 
             180                185                190
Gly Gln Ile Met Thr Phe Gly Ser Pro Val Ile Gly Cys Gly Phe Ile 
         195                200                205
Ser Gly Trp Asn Leu Val Ser Met Cys Val Glu Tyr Val Leu Leu Trp 
     210                215                220
Lys Val Tyr Gln Lys Thr Pro Ala Leu Ala Val Lys Ala Gly Leu Lys 
 225                230                235                240
Glu Glu Glu Thr Glu Leu Lys Gln Leu Asn Leu His Lys Asp Thr Glu 
                 245                250                255
Pro Lys Pro Leu Glu Gly Thr His Leu Met Gly Val Lys Asp Ser Asn 
             260                265                270
Ile His Glu Leu Glu His Glu Gln Glu Pro Thr Cys Ala Ser Gln Met 
         275                280                285
Ala Glu Pro Phe Arg Thr Phe Arg Asp Gly Trp Val Ser Tyr Tyr Asn 
     290                295                300
Gln Pro Val Phe Leu Ala Gly Met Gly Leu Ala Phe Leu Tyr Met Thr 
 305                310                315                320
Val Leu Gly Phe Asp Cys Ile Thr Thr Gly Tyr Ala Tyr Thr Gln Gly 
                 325                330                335
Leu Ser Gly Ser Ile Leu Ser Ile Leu Met Gly Ala Ser Ala Ile Thr 
             340                345                350
Gly Ile Met Gly Thr Val Ala Phe Thr Trp Leu Arg Arg Lys Cys Gly 
         355                360                365
Leu Val Arg Thr Gly Leu Ile Ser Gly Leu Ala Gln Leu Ser Cys Leu 
     370                375                380
Ile Leu Cys Val Ile Ser Val Phe Met Pro Gly Ser Pro Leu Asp Leu 
 385                390                395                400
Ser Val Ser Pro Phe Glu Asp Ile Arg Ser Arg Phe Ile Gln Gly Glu 
                 405                410                415
Ser Ile Thr Pro Thr Lys Ile Pro Glu Ile Thr Thr Glu Ile Tyr Met 
             420                425                430
Ser Asn Gly Ser Asn Ser Ala Asn Ile Val Pro Glu Thr Ser Pro Glu 
         435                440                445
Ser Val Pro Ile Ile Ser Val Ser Leu Leu Phe Ala Gly Val Ile Ala 
     450                455                460
Ala Arg Ile Gly Leu Trp Ser Phe Asp Leu Thr Val Thr Gln Leu Leu 
 465                470                475                480
Gln Glu Asn Val Ile Glu Ser Glu Arg Gly Ile Ile Asn Gly Val Gln 
                 485                490                495
Asn Ser Met Asn Tyr Leu Leu Asp Leu Leu His Phe Ile Met Val Ile 
             500                505                510
Leu Ala Pro Asn Pro Glu Ala Phe Gly Leu Leu Val Leu Ile Ser Val 
         515                520                525
Ser Phe Val Ala Met Gly His Ile Met Tyr Phe Arg Phe Ala Gln Asn 
     530                535                540
Thr Leu Gly Asn Lys Leu Phe Ala Cys Gly Pro Asp Ala Lys Glu Val 
 545                550                555                560
Arg Lys Glu Asn Gln Ala Asn Thr Ser Val Val 
                 565                570



<210> 8921
<211> 2129
<212> DNA
<213> Rattus norvegicus
<308> U76714
<400> 8921

gaggccgct  gagagcagg  ttagggtct  ctgcggccg  tggaccctc  aacccgctt  60
cataaggct  tagctttcc  acttcagct  cagtgttag  taagtttgg  aagaagaca  120
aaagaagac  ccggtgggc  gctttgctg  tctttgcct  agttgtcct  tggggtctt  180
cggcacaag  ctgctgtgc  tatagccgt  ctatctccg  ttcctcaca  tcctgtgaa  240
aagccctgg  caagagcag  taaagctac  agcatccga  caaacaagg  gagagcgtc  300
ggtgccatg  ccaagtcaa  agatcagac  catcaggaa  gatgctgtg  atctttagc  360
aactacctg  cctcagcaa  attcctcct  taccttggc  actctctct  cacttgggg  420
gatcggatg  ggcactttg  agtgtctgt  tttctggtg  aactctacg  aaacagcct  480
ctcttgaca  ctgtctacg  gttggtggt  gcaggctct  ttctggtcc  gggagccat  540
attggtgac  gggtggata  gaatgccag  cttaaagtg  cccagacgt  cctggtggt  600
cagaatgta  cagtcattc  ctgcgggat  atcctgatg  tggttttct  acacaagaa  660
gagcttctg  acatgtatc  tggatgggt  cttactgtc  gctacatcc  gatcatcac  720
attgcaaac  ttgcgaatt  ggccagtac  gccactgca  ttacaatcc  aagggactg  780
attgttgtc  tagcaggag  aaacaggag  agattagca  acatgaatg  taccattag  840
aggattgac  agctaacca  catcctggc  cccatggct  ttggccaga  tatgacatt  900
ggttcccca  tcattggct  tggtttcat  tctggttgg  atttggtgt  catgtgtgt  960
gagtacttc  tgctctgga  ggtttacca  aagacccct  ctctggctg  aaaagctgc  1020
ctcaaggta  aggagtcag  actgaagca  ctgacctca  ctaaagata  ggagccaaa  1080
cctttggag  gaactcacc  aatgggtga  aaagactct  acatccgtg  acttgaatg  1140
gaacaagaa  ccacctgtg  ctcccagat  gcagaaccc  tccgcactt  tcgagatgg  1200
tgggtctcc  actataacc  gcccgtatt  ttgggctgg  atgggcctg  ctttcctct  1260
tatgacagt  ctgggcttc  actgtatcg  cacagtata  gcttacact  agggactga  1320
tggttccat  ctcagtgtt  tgatgggag  atcagcaat  actggaata  tgggaactg  1380
ggccttcac  tggctacgt  gaaaatgtg  ccttgttcg  actggtctg  tctcaggac  1440
ggctcagct  tcttgtttg  tcttgtgtg  gatctccgt  ttcatgcct  gaagcccct  1500
ggacctgtc  gtttctcca  ttgaagata  ccgttctag  tttatacat  aggaggcag  1560
gtcctcaac  accaaaata  ctgaaacgg  aatgcttat  tctaatgtg  ctaatgttg  1620
caataccgt  catgagatg  gtactaaat  cgtccccat  atctccgtc  gcctgctgt  1680
tgcaggagt  attgctgct  gaatcggtc  ttggtcctt  gatttgact  tgacacagt  1740
gctgcaaga  aatgtaatt  aatcagaaa  aggcattat  aatggtgtg  agaactcca  1800
gaactacct  ctcgacctt  tgcatttca  catggtcat  ttggcccca  atcctgaag  1860
ttttggctt  ctagtattg  tttcagtcy  ctttgtggc  atgggacat  ttatgtatt  1920
ccgttttgc  csgaagact  tgggcaacc  gatttttgt  tgtgctcct  atgaaaagg  1980
agttacaga  gaaagtcag  ctaatacat  tgttgtgta  aatagttta  ctgtggccc  2040
tgttactag  tttgtggag  gcatgtgtg  ttattttgt  ctacagaat  ccaataaat  2100
cctgcactt  taaaaaaaa  aaaaaaaaa  2129



<210> 8922
<211> 405
<212> PRT
<213> Rattus norvegicus
<308> AAD00260
<400> 8922

Met Thr Lys Ser Arg Asp Gln Thr His Gln Glu Gly Cys Cys Gly Ser 
  1               5                  10                  15
Leu Ala Asn Tyr Leu Thr Ser Ala Lys Phe Leu Leu Tyr Leu Gly His 
             20                  25                  30
Ser Leu Ser Thr Trp Gly Asp Arg Met Trp His Phe Ala Val Ser Val 
         35                  40                  45
Phe Leu Val Glu Leu Tyr Gly Asn Ser Leu Leu Leu Thr Ala Val Tyr 
     50                  55                  60
Gly Leu Val Val Ala Gly Ser Val Leu Val Leu Gly Ala Ile Ile Gly 
 65                  70                  75                  80
Asp Trp Val Asp Lys Asn Ala Arg Leu Lys Val Ala Gln Thr Ser Leu 
                 85                  90                  95
Val Val Gln Asn Val Ser Val Ile Leu Cys Gly Ile Ile Leu Met Met 
             100                105                110
Val Phe Leu His Lys Asn Glu Leu Leu Asn Met Tyr His Gly Trp Val 
         115                120                125
Leu Thr Val Cys Tyr Ile Leu Ile Ile Thr Ile Ala Asn Ile Ala Asn 
     130                135                140
Leu Ala Ser Thr Ala Thr Ala Ile Thr Ile Gln Arg Asp Trp Ile Val 
 145                150                155                160
Val Val Ala Gly Glu Asn Arg Ser Arg Leu Ala Asp Met Asn Ala Thr 
                 165                170                175
Ile Arg Arg Ile Asp Gln Leu Thr Asn Ile Leu Ala Pro Met Ala Val 
             180                185                190
Gly Gln Ile Met Thr Phe Gly Ser Pro Val Ile Gly Cys Gly Phe Ile 
         195                200                205
Ser Gly Trp Asn Leu Val Ser Met Cys Val Glu Tyr Phe Leu Leu Trp 
     210                215                220
Lys Val Tyr Gln Lys Thr Pro Ala Leu Ala Val Lys Ala Ala Leu Lys 
 225                230                235                240
Val Glu Glu Ser Glu Leu Lys Gln Leu Thr Ser Pro Lys Asp Thr Glu 
                 245                250                255
Pro Lys Pro Leu Glu Gly Thr His Leu Met Gly Glu Lys Asp Ser Asn 
             260                265                270
Ile Arg Glu Leu Glu Cys Glu Gln Glu Pro Thr Cys Ala Ser Gln Ile 
         275                280                285
Ala Glu Pro Phe Arg Thr Phe Arg Asp Gly Trp Val Ser Tyr Tyr Asn 
     290                295                300
Gln Pro Val Phe Leu Gly Trp His Gly Pro Gly Phe Pro Leu Tyr Asp 
 305                310                315                320
Ser Pro Gly Leu Arg Leu Tyr Arg His Ser Ile Cys Leu His Ser Gly 
                 325                330                335
Thr Glu Trp Phe His Pro Gln Cys Phe Asp Gly Ser Ile Ser Asn Asn 
             340                345                350
Trp Asn Asn Gly Asn Cys Gly Leu His Leu Ala Thr Ser Lys Met Trp 
         355                360                365
Pro Cys Ser Asp Trp Ser Val Leu Arg Thr Gly Ser Ala Phe Leu Phe 
     370                375                380
Asp Leu Val Cys Asp Leu Arg Val His Ala Trp Lys Pro Leu Gly Pro 
 385                390                395                400
Val Cys Phe Ser Ile 
                 405



<210> 8923
<211> 2286
<212> DNA
<213> Homo sapiens
<308> AK002038
<400> 8923

cttaaagaa  aggaaactg  attgaaaca  ctgaattta  acaaagata  tgagccaaa  60
cccctggag  gaactcatc  aatgggtgt  aaagactct  acatccatg  gcttgaaca  120
gagcaagag  ctacttgtg  ctcccagat  gctgagccc  tccgtacct  ccgagatgg  180
tgggtctcc  actacaacc  gcctgtgtt  ctggctggc  tgggtcttg  tttccttta  240
atgactgtc  tgggctttg  ctgcatcac  acagggtac  cctacactc  gggactgag  300
ggttccatc  tcagtattt  gatgggagc  tcagctata  ctggaataa  gggaactgt  360
gcttttact  ggctacgtc  aaaatgtgg  ttggttcgg  caggtctga  ctcaggatt  420
gcacagctt  cctgtttga  cttgtgtgt  atctctgta  tcatgcctg  aagccccct  480
gacttgtcc  tttctcctt  tgaagatat  cgatcaagg  tcattcaag  agagtcaat  540
acacctacc  agatacctg  aattacaac  gaaatacat  tctaatggg  ctaattctg  600
taatattgt  ccggagaca  gtcctgaat  tgtgcccat  atctctgtc  gtctgctgt  660
tgcaggcgt  attgctgct  gaatcggtc  ttggtcctt  gatttaact  tgacacagt  720
gctgcaaga  aatgtaatt  aatctgaaa  aggcattat  aatggtgta  agaactcca  780
gaactatct  cttgatctt  tgcatttca  catggtcat  ctggctcca  atcctgaag  840
ttttggctt  ctcgtattg  tttcagtct  ctttgtggc  atgggccac  ttatgtatt  900
ccgatttgc  caaaatact  tgggaaaca  gctctttgc  tgcggtcct  atgcaaaag  960
agttaggaa  gaaaatcaa  caaatacat  tgttgtttg  gacagttta  ctgttgcta  1020
cctgttact  gattatata  agcacatgt  cttattttg  gctgcagaa  tccaataaa  1080
ggctgggtg  tttgctctg  ttttaccac  gctgtgcct  gagaactaa  agctgttta  1140
gaaacctaa  tcagcagaa  ttaactgat  aatttccct  atgttgagg  atggaaaaa  1200
aattggaaa  gaaaaactc  gtttaaata  ggagactat  atgataaca  tgaattccc  1260
tatttctca  gagtagata  aatcttacg  aaaagagtg  ttagtcacg  gaattcagt  1320
atcatttga  agattctta  ctgtactag  attcagata  gtcagtttt  tgcaaaact  1380
actcttgtt  aagactagc  aatttattt  tttgcatct  agttatttt  aaaaacaaa  1440
tcttcaagt  tgaagacta  attttgata  ctaatatta  ccttattga  cctattgat  1500
ttaaggtat  tacatgtat  tggaaaaac  aaacactta  ctagaattc  ctaataagg  1560
ttatggttt  gcttaaaga  cacctttgt  tttttatta  cagatgggg  aacatattg  1620
atgaagcat  tgtagcact  cacagcatg  ttatcatgt  agctgcagg  agaagcaaa  1680
ctgtaaagt  gatttatca  acaatgact  catacagac  tcaaatatg  caatagttt  1740
gtcatagaa  ctagaagcc  aaagccaca  agaagggca  gaatcccaa  ttaactcat  1800
ttatcatca  tagtgatct  tgttgtaga  catgagggt  taagccttc  gcctggcaa  1860
ttacatgta  aaagcccac  cttgtgaag  ttttgtttt  caaatcact  gatttaaca  1920
actcaggta  aatattttt  tttttactg  tttataccc  gaagttatt  ctacattgt  1980
ctacagcaa  aatattcat  aaagtatcc  tttcaaatg  ctttgagaa  aatagaaga  2040
aaaaagttt  tatatattt  aaaaaattg  tttaaaagt  agtttgcaa  atgtctgta  2100
caagatggt  ctttgcctt  accgtttat  tgcactttc  tggagactg  aatacgttg  2160
tatgagcac  ttctttatc  ttggagttt  atcctttgc  tcatctttc  acagtatga  2220
ataatgatt  gctatgttg  aaaatcttt  taaaaaatt  ctatataaa  atattttga  2280
aatctt  2286



<210> 8924
<211> 571
<212> PRT
<213> Homo sapiens
<308> NP_055400
<400> 8924

Met Thr Arg Ala Gly Asp His Asn Arg Gln Arg Gly Cys Cys Gly Ser 
  1               5                  10                  15
Leu Ala Asp Tyr Leu Thr Ser Ala Lys Phe Leu Leu Tyr Leu Gly His 
             20                  25                  30
Ser Leu Ser Thr Trp Gly Asp Arg Met Trp His Phe Ala Val Ser Val 
         35                  40                  45
Phe Leu Val Glu Leu Tyr Gly Asn Ser Leu Leu Leu Thr Ala Val Tyr 
     50                  55                  60
Gly Leu Val Val Ala Gly Ser Val Leu Val Leu Gly Ala Ile Ile Gly 
 65                  70                  75                  80
Asp Trp Val Asp Lys Asn Ala Arg Leu Lys Val Ala Gln Thr Ser Leu 
                 85                  90                  95
Val Val Gln Asn Val Ser Val Ile Leu Cys Gly Ile Ile Leu Met Met 
             100                105                110
Val Phe Leu His Lys His Glu Leu Leu Thr Met Tyr His Gly Trp Val 
         115                120                125
Leu Thr Ser Cys Tyr Ile Leu Ile Ile Thr Ile Ala Asn Ile Ala Asn 
     130                135                140
Leu Ala Ser Thr Ala Thr Ala Ile Thr Ile Gln Arg Asp Trp Ile Val 
 145                150                155                160
Val Val Ala Gly Glu Asp Arg Ser Lys Leu Ala Asn Met Asn Ala Thr 
                 165                170                175
Ile Arg Arg Ile Asp Gln Leu Thr Asn Ile Leu Ala Pro Met Ala Val 
             180                185                190
Gly Gln Ile Met Thr Phe Gly Ser Pro Val Ile Gly Cys Gly Phe Ile 
         195                200                205
Ser Gly Trp Asn Leu Val Ser Met Cys Val Glu Tyr Val Leu Leu Trp 
     210                215                220
Lys Val Tyr Gln Lys Thr Pro Ala Leu Ala Val Lys Ala Gly Leu Lys 
 225                230                235                240
Glu Glu Glu Thr Glu Leu Lys Gln Leu Asn Leu His Lys Asp Thr Glu 
                 245                250                255
Pro Lys Pro Leu Glu Gly Thr His Leu Met Gly Val Lys Asp Ser Asn 
             260                265                270
Ile His Glu Leu Glu His Glu Gln Glu Pro Thr Cys Ala Ser Gln Met 
         275                280                285
Ala Glu Pro Phe Arg Thr Phe Arg Asp Gly Trp Val Ser Tyr Tyr Asn 
     290                295                300
Gln Pro Val Phe Leu Ala Gly Met Gly Leu Ala Phe Leu Tyr Met Thr 
 305                310                315                320
Val Leu Gly Phe Asp Cys Ile Thr Thr Gly Tyr Ala Tyr Thr Gln Gly 
                 325                330                335
Leu Ser Gly Ser Ile Leu Ser Ile Leu Met Gly Ala Ser Ala Ile Thr 
             340                345                350
Gly Ile Met Gly Thr Val Ala Phe Thr Trp Leu Arg Arg Lys Cys Gly 
         355                360                365
Leu Val Arg Thr Gly Leu Ile Ser Gly Leu Ala Gln Leu Ser Cys Leu 
     370                375                380
Ile Leu Cys Val Ile Ser Val Phe Met Pro Gly Ser Pro Leu Asp Leu 
 385                390                395                400
Ser Val Ser Pro Phe Glu Asp Ile Arg Ser Arg Phe Ile Gln Gly Glu 
                 405                410                415
Ser Ile Thr Pro Thr Lys Ile Pro Glu Ile Thr Thr Glu Ile Tyr Met 
             420                425                430
Ser Asn Gly Ser Asn Ser Ala Asn Ile Val Pro Glu Thr Ser Pro Glu 
         435                440                445
Ser Val Pro Ile Ile Ser Val Ser Leu Leu Phe Ala Gly Val Ile Ala 
     450                455                460
Ala Arg Ile Gly Leu Trp Ser Phe Asp Leu Thr Val Thr Gln Leu Leu 
 465                470                475                480
Gln Glu Asn Val Ile Glu Ser Glu Arg Gly Ile Ile Asn Gly Val Gln 
                 485                490                495
Asn Ser Met Asn Tyr Leu Leu Asp Leu Leu His Phe Ile Met Val Ile 
             500                505                510
Leu Ala Pro Asn Pro Glu Ala Phe Gly Leu Leu Val Leu Ile Ser Val 
         515                520                525
Ser Phe Val Ala Met Gly His Ile Met Tyr Phe Arg Phe Ala Gln Asn 
     530                535                540
Thr Leu Gly Asn Lys Leu Phe Ala Cys Gly Pro Asp Ala Lys Glu Val 
 545                550                555                560
Arg Lys Glu Asn Gln Ala Asn Thr Ser Val Val 
                 565                570



<210> 8925
<211> 1792
<212> DNA
<213> Rattus norvegicus
<308> U77483
<400> 8925

cccctccac  aacgcccca  ccccctcct  cttcgcctc  aagagggtg  tctcctacc  60
acccaccca  tcccacttc  cccttccag  gtattctga  aggatgagg  ctatattct  120
gaagtatgc  agatgcaga  gccaccagt  aaagaccat  ggagacaaa  atcccctca  180
ttcgtggtg  agtttctag  gtcaggtcc  gcagacagc  accagacct  ctagaccgt  240
aagggtcta  cctctgcac  ctcacctgg  atattgtaa  ctccattgt  aattcaatt  300
taaaacgta  ttcctatat  ggctttacc  tctgcaaag  gctgaactc  gacccctga  360
cctgctgag  aaactgccc  gctcagcct  aatcactta  taaggtgta  ttcctacat  420
cattaaccc  ctgaggagt  gatagcaca  tctttgaca  attaggaaa  tgactgtca  480
tcaggtccc  gagacagac  ggctgcaca  ccagatacg  tggtagaca  gttcttcag  540
cattagcaa  attccttcg  tgctcattg  tcacttgta  ggagcacca  agcatgcca  600
gtgtctagg  tggcctcag  agtacccat  tccagtacc  gtcccatcc  agcactttc  660
caggtggcc  gtctccttg  ggtatgcaa  acaacggtc  ccacttccc  acagaggaa  720
acggtggga  gtagtcctg  ctctgaagc  gccaactgg  gagcaccaa  acatggtca  780
gggtcatcc  gggctctaa  acatataac  tgcttacag  tacaagaat  gagaagaca  840
agaaacact  ctgtagtgc  cctgggctg  gtctttctt  tgctggagt  aggtgcaac  900
agccaagac  cacacacgg  gctcctcct  atgagaggc  cgtttgtca  ggagctgat  960
tctcctggg  agtctccag  gatctccaa  ggcttcagt  atctgggtc  cttctgctg  1020
tctctgttg  gggggtcga  tcccagaag  acccctaca  gctaaaaag  aaagcgaac  1080
attcgctcg  aatctcgcc  gcttaacca  ttagggttt  ctcgcgccc  aaaggatta  1140
tgacacgat  caaagaagc  agggcgaca  cgcattgca  agagaccgg  tagggaatt  1200
gttgccagg  ctgaattcg  accctactt  aggtagggc  gggcaacca  ggtgcaagg  1260
accagggct  cactgctct  agggtgggt  tcccaagat  ctagaagta  cttcggtgt  1320
gatcggcgc  gtgcagtgc  acggtcgct  gagccagca  cgcgtgcgg  aaggcggcg  1380
gcgcacagc  gcgccccgc  cctgtctgt  gttattgga  tactcgcac  tccgtcggc  1440
gttatcggc  aatggaaaa  gagccggag  tagtggtcg  gcggcagag  gaggtgcgg  1500
gcagacgag  gacagaccc  gcccgcggt  ggcctggca  cggactgcg  tcgcgactc  1560
gccccctgc  ggcggcggc  cggtgcggg  cgggtggac  cgcttgcag  cccgcggga  1620
ggcggagga  gggagccgg  gcggcggag  gtgtgtgcc  cccgcggac  ggtcacgtc  1680
tcgcgcggc  gccggcacc  gcttcgtgc  gaaccagag  gccacagcc  tacgctcgc  1740
gccccgccc  gccgggtgc  gctcgaccg  cgcacgaag  cgcgcccgg  ag  1792



<210> 8926
<211> 1062
<212> DNA
<213> Rattus norvegicus
<308> U77583
<400> 8926

atggcgagc  gcagcggct  caaggccga  tttatcgtc  gtgggaaat  caaactggt  60
cggaagatc  gatctggtt  cttcgggga  atttatcta  cgatcaaca  caccaatgg  120
gaggaagtg  cagtgaaac  agaatccca  aaggccagg  atccccagt  gctgtacga  180
agcaaactg  ataagattc  tcaaggtgg  gttggcatc  ctcacatac  gtggtatgg  240
caaggaaaa  actataatg  gctagtcat  gatcttctg  gacccagcc  cgaagacct  300
ttcaatttc  gttcaagaa  gttcactat  aagactgta  ttatgttag  tgaccagat  360
atcagtaga  ttgaatatg  gcatacaaa  aattttata  acagagaca  taaaccaga  420
aacttccta  tgggtattg  gcgtcactg  aataagtgt  tagaatctc  agtggggaa  480
aggaaaaga  gcatgactg  tagtccttc  caggaccca  ctttctcag  attaaacca  540
ttattcctt  ttgattttg  tttggccaa  aagtacaga  acaacagga  aaggcaaca  600
ataccatac  gggaagata  aaacctcac  ggcactgcc  ggtatgcca  catcaatgc  660
catcttggc  ttgagcaga  tcgccgaga  gacatggaa  ctttaggat  tgttttgat  720
tattttaat  gaaccagtc  gccatggca  gggctaaag  ctgcaacaa  gaaacaaaa  780
tatgaaaag  ttagtgaaa  gaagatgtc  actcctgtt  aagttttgt  taaggggtt  840
cctgcagaa  ttgccatgt  cttaaatta  tgtcgtggg  tgcgctttg  ggaagctcc  900
gattacatg  atctgaggc  gctgttccg  atcctcttc  ggaccctga  ccaccagta  960
gactacacg  ttgattgga  gatgttaaa  cagaaagca  cccagcagg  agcctcttc  1020
agtgggcag  gtcagcagg  ccaaacccc  acaggtttc  aa  1062



<210> 8927
<211> 325
<212> PRT
<213> Rattus norvegicus
<308> AAB19228
<400> 8927

Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
  1               5                  10                  15
Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
             20                  25                  30
Leu Ala Ile Asn Ile Thr Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
         35                  40                  45
Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
     50                  55                  60
Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
 65                  70                  75                  80
Gln Gly Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                 85                  90                  95
Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Thr Met Lys Thr 
             100                105                110
Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
         115                120                125
Thr Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
     130                135                140
Gly Ile Gly Arg His Cys Asn Lys Leu Phe Leu Ile Asp Phe Gly Leu 
 145                150                155                160
Ala Lys Lys Tyr Arg Asp Asn Arg Thr Arg Gln His Ile Pro Tyr Arg 
                 165                170                175
Glu Asp Lys Asn Leu Thr Gly Thr Ala Arg Tyr Ala Ser Ile Asn Ala 
             180                185                190
His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly 
         195                200                205
Tyr Val Leu Met Tyr Phe Asn Arg Thr Ser Leu Pro Trp Gln Gly Leu 
     210                215                220
Lys Ala Ala Thr Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys 
 225                230                235                240
Met Ser Thr Pro Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe 
                 245                250                255
Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro 
             260                265                270
Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Thr Leu 
         275                280                285
Asn His Gln Tyr Asp Tyr Thr Phe Asp Trp Thr Met Leu Lys Gln Lys 
     290                295                300
Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln 
 305                310                315                320
Thr Pro Thr Gly Phe 
                 325



<210> 8928
<211> 222
<212> DNA
<213> Rattus norvegicus
<308> U77626
<400> 8928

gaactgaaa  agatttcat  gtccactta  atgtttccc  ttttctggt  acatttctt  60
aatagaaat  tcatattct  tttgaagta  ttcccttta  tacttttga  tatttttaa  120
catattttt  ataagttat  tgtaacttt  ggtagcgaa  gtcttttta  aattgttag  180
gtacttgta  gaatagctt  ttaaaaacc  taaagtaaa  ta  222



<210> 8929
<211> 429
<212> DNA
<213> Rattus norvegicus
<308> U77829
<400> 8929

gtgaggcga  gctgagcag  aatggccct  tggacctct  tgatgggac  tctggtgga  60
tctcacagg  agttctgtg  caaagatgg  tgaaagcta  ggactcatg  ggaagctgg  120
taactgaac  aagccatgt  caagaatgg  aagccagaa  atgggatgg  ggagtttga  180
tcaggtgga  agttctaaa  gtacaaatg  tttcgtata  aggtaccac  tgtgggtcc  240
tttaactga  ggcatggca  gctccacac  aggtccttc  tttctgaat  tcaagggct  300
ctctgacaa  tggacagtg  agtgggtgc  ccttttcca  aggtgactg  atggatgct  360
gaacagaag  tttgccaaa  agacattgt  ctgtcaaga  ttttaccat  aaaagtgca  420
tattgtagc  429



<210> 8930
<211> 429
<212> DNA
<213> Rattus norvegicus
<308> U77829
<400> 8930

gtgaggcga  gctgagcag  aatggccct  tggacctct  tgatgggac  tctggtgga  60
tctcacagg  agttctgtg  caaagatgg  tgaaagcta  ggactcatg  ggaagctgg  120
taactgaac  aagccatgt  caagaatgg  aagccagaa  atgggatgg  ggagtttga  180
tcaggtgga  agttctaaa  gtacaaatg  tttcgtata  aggtaccac  tgtgggtcc  240
tttaactga  ggcatggca  gctccacac  aggtccttc  tttctgaat  tcaagggct  300
ctctgacaa  tggacagtg  agtgggtgc  ccttttcca  aggtgactg  atggatgct  360
gaacagaag  tttgccaaa  agacattgt  ctgtcaaga  ttttaccat  aaaagtgca  420
tattgtagc  429



<210> 8931
<211> 1038
<212> DNA
<213> Rattus norvegicus
<308> U77931
<400> 8931

ggctgctag  cgccggccg  ggcgaggcg  cgcgcggaa  accgcggcc  ggggggcgg  60
cccggcggg  gaacaccga  gcggaggtt  cccccacac  cgcgggaca  gcccgcccg  120
ccccgccac  cacctcggg  gaggcgatg  gggggtgga  cgaggcccc  cggggaggg  180
acccgcgcc  gcacccgcc  ggctccccg  gagcggccg  gacgcccgc  gcagctgag  240
cgatccacg  gaagggccc  gctcgcgtc  agagtcgcc  ccgccgccg  cccccccga  300
tgtccgggc  ccccgcccc  ccgggggcc  gctggttcc  cccgctccg  aacccccgc  360
gggttggac  cgccgcccc  gagcccgcg  cgcgcgccg  cccccgacc  gccccccga  420
gggaagaag  aggggggaa  agaggtggc  acgacgcgg  ggacgacgg  gccccgcgg  480
gaagagggg  gggcgggcc  gggcggaaa  gacgggggg  ctccccgga  gtgggagag  540
gcggcggcg  ctcgtccag  cgcggcgcg  gcccagccc  gcttcgcgc  ccagcccga  600
cgacccagc  cttagagcc  atccttatc  cgaagttac  gatccggct  gccgacttc  660
cttacctac  ttgttccaa  atgccagag  ctgttcacc  tggagacct  ctgcggata  720
gggtacggc  cggcgcgag  tttacaccc  ctcccccgg  ttttcaagg  ccagcgaga  780
ctcaccgga  gccgccgga  ccgcgacgc  ttccaaggc  cgggcccct  tctcggggc  840
aacccattc  agggcgccc  gcccttcac  aagaaaaga  aactctccc  ggggctccc  900
ccggcttct  cgggatcgg  cgcgttacc  cactggacg  ctcgcggcg  ccatctccg  960
cactccgga  tcggagatc  gaacccgac  ccctttcga  cggccgagc  tctgtcaag  1020
cttggacca  gtaaaaat  1038



<210> 8932
<211> 295
<212> PRT
<213> Rattus norvegicus
<308> AAK21974
<400> 8932

Met Gly Gly Trp Ser Glu Ala Pro Arg Gly Gly Asp Pro Arg Arg His 
  1               5                  10                  15
Pro Pro Gly Ser Pro Gly Ala Ala Ala Thr Pro Ala Ala Ala Glu Ala 
             20                  25                  30
Ile His Gly Lys Gly Pro Ala Arg Val Gln Ser Arg Arg Arg Arg Arg 
         35                  40                  45
Pro Pro Arg Val Ser Gly Pro Pro Ala Pro Pro Gly Ala Arg Trp Phe 
     50                  55                  60
Leu Pro Leu Arg Asn Pro Arg Gly Val Gly Pro Ala Ala Pro Glu Pro 
 65                  70                  75                  80
Ala Pro Arg Ala Asp Pro Arg Pro Ala Pro Arg Arg Glu Glu Gly Gly 
                 85                  90                  95
Gly Lys Arg Gly Gly Asp Asp Ala Gly Asp Asp Gly Ala Pro Arg Gly 
             100                105                110
Arg Gly Glu Gly Gly Pro Gly Arg Lys Gly Arg Gly Val Ser Pro Asp 
         115                120                125
Val Gly Glu Gly Gly Gly Ala Ser Ser Ser Arg Gly Ala Arg Pro Ala 
     130                135                140
Pro Leu Arg Ala Pro Ala Arg Pro Thr Gln Pro Leu Glu Pro Ile Leu 
 145                150                155                160
Ile Pro Lys Leu Arg Ile Arg Leu Ala Asp Phe Pro Tyr Leu His Cys 
                 165                170                175
Ser Asn Met Pro Glu Ala Val His Leu Gly Asp Leu Leu Arg Ile Trp 
             180                185                190
Val Arg Pro Gly Ala Arg Phe Thr Pro Ser Pro Pro Asp Phe Gln Gly 
         195                200                205
Pro Ala Arg Ala His Arg Thr Pro Pro Glu Pro Arg Arg Phe Pro Arg 
     210                215                220
His Gly Pro Leu Ser Arg Gly Glu Pro Ile Pro Gly Arg Pro Ala Leu 
 225                230                235                240
His Lys Glu Lys Arg Thr Leu Pro Gly Ala Pro Ala Gly Phe Ser Gly 
                 245                250                255
Ile Gly Arg Val Thr Ala Leu Asp Ala Ser Arg Arg Pro Ser Pro Pro 
             260                265                270
Leu Arg Ile Arg Arg Ser Glu Pro Asp Ser Leu Ser Ile Gly Arg Ala 
         275                280                285
Ser Val Lys Ser Trp Thr Lys 
     290                295



<210> 8933
<211> 3365
<212> DNA
<213> Rattus norvegicus
<308> U77933
<400> 8933

ctggaaatg  cggcgtcga  cgggaggtc  cagtcttcc  tgcacagga  ggggctgat  60
gcggctgac  ggaggagca  gattttggc  gtgtgtgga  tgcatcctg  ccatcagga  120
actctgaaa  agaatcgag  ggtgctggc  aaacagctg  tgctgagcg  actgttaga  180
catctccta  aaaaggaca  tatcacttt  gaaatgagg  agctaatcc  ggccaaagg  240
ggcagtttc  gccagaatg  ggaactcct  aacctgctg  caaagagag  accccaggc  300
tttgatgcc  tctgtgaag  cctgcggga  accaggcag  gtcacttgg  agacttact  360
ctcacaacc  tctctgata  ccagcacat  ctcccaccg  tgagctgtg  ctatgactc  420
agtctcccc  tctcggtgt  tgagtcctg  cctcctcac  agcagtccc  cctatccac  480
gatactatg  aacactcct  agataatgg  gatggtcct  cctgtcttc  ggtgaagcc  540
tgcactcct  agttttacc  ggcacacta  cagctggcc  ataggttgc  gtctcagcc  600
cgtggcttg  cactggtga  gagtaatgt  cacttcact  gagagaaag  cctggaatt  660
cgctccgga  gggatgtgg  ccacactac  ctagtcacc  tcttcaagc  tttgggcta  720
aatgtccat  tgctgtatg  ccagactgc  caggaaatg  aagagaaac  tcagaattt  780
gcacagtta  ctgcacacc  ggtcacaga  tcctgcata  tagcactcc  ctcacatgg  840
gtggaaggt  gcatctacg  ggtggatgg  aaactgctt  agctccaag  ggtttttcg  900
ctttttgac  atgctaact  tccaagtct  cagaacaaa  caaaaatgt  cttcatcca  960
gcatgtcgt  gagatgaga  agatagagg  gttgaccag  aagatggaa  gaaccatgc  1020
caatcccct  gatgtgagg  gagtgatgc  ggcaaggag  aattaatga  gatgagact  1080
cctactcgc  cagacatga  atgtggcta  gcttgcctt  aaggcaatg  tgccatgcg  1140
aataccaaa  ggggttcct  gtacattga  gccctcact  aggtgttct  tgagagagc  1200
tgtgacatg  acgtggccg  catgcttgt  aaggtgaat  cccttatca  ggagcgtga  1260
ggctatgcc  ctggtacag  attccaccg  tgcaaggag  tgtctgagt  ctgtagtac  1320
ctgtgccag  agctctacc  gttcccagg  tacccaccc  cgtgatgcc  cctgctagt  1380
atgctgttg  aggccactg  accacgggg  acaatggag  cttctcttc  agatgtttt  1440
gttctgtct  ctccctcag  gatatgaga  tctcccaag  ttgtttcct  tcagccatc  1500
ccgtctttg  gggtgaaac  tgaggacag  tcctctggt  tggtgttct  ttcctgtag  1560
gccagctat  aatggatct  ttgccagaa  cattttggc  atagccaat  agactagaa  1620
atgacattg  gaacacagt  ttattgtgg  gagagggca  acggatttc  caatgtttg  1680
gatattttt  ttcccaggg  tcttaggga  actttgatt  ttgcttttt  atatcagtt  1740
aggactttc  gatatcatc  cctactttt  ttttcatat  tgcaacctc  ttttttcca  1800
agtgaagat  tggaaaatg  cccaattta  tgcagttgt  gtcatctgt  atgaagcgg  1860
aggtgagac  ctgctactt  agcagaagt  tcagacctt  gagttcagg  cttaggtga  1920
ggacagtcc  tcagctttt  cattggttt  tttgtgttc  ttgtaccca  cttttgagc  1980
gagcctggg  tctgcttgc  gtgacactg  aagttatat  cgtttccct  gttatgaat  2040
gtcactgaa  tgaacctta  tgggcatat  aacataaaa  tgcagtgac  ggtgagtgt  2100
ctgtgtctc  tactgtcac  tgtcaccag  atatctctc  ttccttact  tggtttctg  2160
tgtgcagtt  aactacttg  tggctgacc  ccaagaacc  tcttgcttt  cattggttc  2220
cctccttga  ccattcact  cttctgcca  gtctgtgaa  tcttccctt  tagaatgtt  2280
ctggccact  aagcagtac  gcttcagca  aaggtttct  cggttttct  cggcagtgt  2340
tccattctc  ctgtttctc  gttttagtg  ggatagtac  ataggtgat  taacctaga  2400
gcacttatc  ctgctctta  gaaactttc  tattcttaa  aaccttttg  atttccatt  2460
ttttcctct  ttccagttt  ttctccaca  gacagagta  ttttgtttt  ttttaatat  2520
tggtgatgt  actcccttg  taagaacat  agcttcctg  tacacctca  ctaaaattc  2580
aattcttac  cagtttatg  gatccggct  ttacgttcc  tttggatct  attagatgg  2640
gatttctct  tgtgttcag  ccctcagtt  ctcagctca  tgttgcaag  gttctgagc  2700
cttctttaa  atagtctct  attcttgag  ctggcggag  cctcttgac  gtgatgttg  2760
tgaagtaag  cttctgtac  tccttagga  ggcatcatg  tggtccttg  gcttactgc  2820
ggttgtaat  gcacgtttc  cttgctccc  ccaaagctg  aggctccaa  agagcagga  2880
tgtactcct  acttattgg  tattcagta  ggcacttac  aggtcttca  tgaatgttt  2940
ctgagtaaa  gaaggagac  agcagctaa  tttagttag  gcctatctt  tgcgatttc  3000
aaattgcta  tatagtact  agtttaatt  gtatttgta  tcttgtggg  gtttttttc  3060
aggtgtttt  tttttatcc  ctgttttgt  gttttttta  attgtttga  gatgtatca  3120
gtgtgagac  acttctttc  catctccat  gtgccccgc  aatttgagg  ctatggtag  3180
tgaggtgct  aattaatgt  tgtcgtatg  accaggtgg  ttgaagact  gctgccaaa  3240
tctgccttt  ggtcagtat  ggatgcatg  gtggtagac  cttcacact  cccactgcc  3300
agattttgt  ttgccatca  gtgccaaat  aatgtcgat  cttactact  acaaaaaaa  3360
aaaaa  3365



<210> 8934
<211> 452
<212> PRT
<213> Rattus norvegicus
<308> AAB96379
<400> 8934

Met Ala Ala Ser Ser Gly Arg Ser Gln Ser Ser Leu His Arg Lys Gly 
  1               5                  10                  15
Leu Met Ala Ala Asp Arg Arg Ser Arg Ile Leu Ala Val Cys Gly Met 
             20                  25                  30
His Pro Asp His Gln Glu Thr Leu Lys Lys Asn Arg Val Val Leu Ala 
         35                  40                  45
Lys Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys Asp 
     50                  55                  60
Ile Ile Thr Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Gly Gly Ser 
 65                  70                  75                  80
Phe Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly Pro 
                 85                  90                  95
Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu Arg Glu Thr Arg Gln Gly 
             100                105                110
His Leu Glu Asp Leu Leu Leu Thr Thr Leu Ser Asp Ile Gln His Ile 
         115                120                125
Leu Pro Pro Leu Ser Cys Asp Tyr Asp Ser Ser Leu Pro Phe Ser Val 
     130                135                140
Cys Glu Ser Cys Pro Pro His Lys Gln Ser Arg Leu Ser Thr Asp Thr 
 145                150                155                160
Met Glu His Ser Leu Asp Asn Gly Asp Gly Pro Pro Cys Leu Gln Val 
                 165                170                175
Lys Pro Cys Thr Pro Glu Phe Tyr Gln Ala His Tyr Gln Leu Ala Tyr 
             180                185                190
Arg Leu Gln Ser Gln Pro Arg Gly Leu Ala Leu Val Met Ser Asn Val 
         195                200                205
His Phe Thr Gly Glu Lys Asp Leu Glu Phe Arg Ser Gly Gly Asp Val 
     210                215                220
Asp His Thr Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asn Val 
 225                230                235                240
His Val Leu Tyr Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln 
                 245                250                255
Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val 
             260                265                270
Ala Leu Leu Ser His Gly Val Glu Gly Gly Ile Tyr Gly Val Asp Gly 
         275                280                285
Lys Leu Leu Gln Leu Gln Glu Val Phe Arg Leu Phe Asp Asn Ala Asn 
     290                295                300
Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys 
 305                310                315                320
Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp Gly Lys Asn 
                 325                330                335
His Ala Gln Ser Pro Gly Cys Glu Glu Ser Asp Ala Gly Lys Glu Glu 
             340                345                350
Leu Met Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr 
         355                360                365
Ala Cys Leu Lys Gly Asn Ala Ala Met Arg Asn Thr Lys Arg Gly Ser 
     370                375                380
Trp Tyr Ile Glu Ala Leu Thr Gln Val Phe Ser Glu Arg Ala Cys Asp 
 385                390                395                400
Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Glu 
                 405                410                415
Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Glu Met 
             420                425                430
Ser Glu Tyr Cys Ser Thr Leu Cys Gln Gln Leu Tyr Leu Phe Pro Gly 
         435                440                445
Tyr Pro Pro Thr 
     450



<210> 8935
<211> 1048
<212> DNA
<213> Homo sapiens
<308> AF314175
<400> 8935

atgcatcct  atcatcagg  aactctaaa  aagaaccga  tggtgctag  caaacagct  60
ttgttgagc  aattgttag  acatcttct  gagaaggac  tcatcacct  ggaaatgag  120
gagctcatc  aggccaaag  gggcagttt  agccagaat  tggaactcc  caacttgct  180
cctaagagg  gtccccaag  ttttgatgc  ttctgtgaa  ccttgcact  ctgaatttt  240
tcaaacaca  ttccagctg  catataggt  gcagtctcg  cctcgtggc  tagcactgg  300
gttgagcaa  gtgcacttc  ctggagaga  agaactgga  tttcgctct  gaggggatg  360
ggaccacag  actctagtc  ccctcttca  gcttttggg  tatgacgtc  atgttctat  420
tgaccagac  gcacaggaa  tgcaagaga  actgcagaa  tttgcacag  tacctgcac  480
ccgagtcac  gactgctgc  tcgtggcac  cctctcgca  ggtgtggag  gcgccatct  540
tggtgtgga  gggaaactg  tccagctcc  agaggtttt  cagctcttt  acaacgcca  600
ccgcccaag  ctacagaac  aaccaaaaa  gttcttcat  caggcctgc  gtggagatg  660
gactaatcg  ggggttgac  aacaagatg  aaagaacca  gcaggatcc  ctgggtgcg  720
ggagagtga  gccggtaaa  aaaagttgc  gaagatgag  ctgcccacg  gctcagaca  780
gatatgcgg  tatgcctgc  tcaaaggga  tgccgccat  cggaacacc  aacgaggtt  840
ctggtacat  gaggctctt  ctcaagtgt  ttctgagcg  gcttgtgat  tgcacgtgg  900
cgacatgct  gttaaggtg  acgcactta  caaggatcg  gaaggttat  ctcctggca  960
agaattcca  cggtgcaag  agatgtctg  atactgcag  actctgtgc  gccacctct  1020
cctgttccc  ggacaccct  ccacatga  1048



<210> 8936
<211> 435
<212> PRT
<213> Homo sapiens
<308> P42575
<400> 8936

Met Ala Ala Asp Arg Gly Arg Arg Ile Leu Gly Val Cys Gly Met His 
  1               5                  10                  15
Pro His His Gln Glu Thr Leu Lys Lys Asn Arg Val Val Leu Ala Lys 
             20                  25                  30
Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys Asp Ile 
         35                  40                  45
Ile Thr Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Val Gly Ser Phe 
     50                  55                  60
Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly Pro Gln 
 65                  70                  75                  80
Ala Phe Asp Ala Phe Cys Glu Ala Leu Arg Glu Thr Lys Gln Gly His 
                 85                  90                  95
Leu Glu Asp Met Leu Leu Thr Thr Leu Ser Gly Leu Gln His Val Leu 
             100                105                110
Pro Pro Leu Ser Cys Asp Tyr Asp Leu Ser Leu Pro Phe Pro Val Cys 
         115                120                125
Glu Ser Cys Pro Leu Tyr Lys Lys Leu Arg Leu Ser Thr Asp Thr Val 
     130                135                140
Glu His Ser Leu Asp Asn Lys Asp Gly Pro Val Cys Leu Gln Val Lys 
 145                150                155                160
Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr Arg 
                 165                170                175
Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val His 
             180                185                190
Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val Asp 
         195                200                205
His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val His 
     210                215                220
Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln Asn 
 225                230                235                240
Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val Ala 
                 245                250                255
Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly Lys 
             260                265                270
Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn Cys 
         275                280                285
Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg 
     290                295                300
Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp Gly Lys Asn His 
 305                310                315                320
Ala Gly Ser Pro Gly Cys Glu Glu Ser Asp Ala Gly Lys Glu Lys Leu 
                 325                330                335
Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala 
             340                345                350
Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp 
         355                360                365
Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met 
     370                375                380
His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg 
 385                390                395                400
Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser 
                 405                410                415
Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His 
             420                425                430
Pro Pro Thr 
         435



<210> 8937
<211> 7628
<212> DNA
<213> Rattus norvegicus
<308> U78090
<400> 8937

cccgctgta  ttcaccagg  agtactagg  catagatcc  gtgttccgg  ctcggcgct  60
cgggcttcc  agggctggg  ccgggacgc  gcctcccgc  atggcgcag  tggagggtt  120
ttacttctc  gccgccttg  gctgcacct  cctggtgtc  tgcctgctc  tctccgcct  180
cagccgcgc  ctgcgtgag  cttacatgg  cgagatctt  cacctgccg  aggcgcagc  240
ctactgcga  ggccgcttc  cactgtcac  gtgggatcc  atgattact  cattacctg  300
cctgtacct  gtgtcggtc  gagtggtca  acctgccag  tggatcctt  gctggtctg  360
gcatgtcgt  tgctccatc  gaatgctca  atttgtcaa  cttctcttc  gtgttggca  420
cttctattt  ctgtatttg  tcttcagga  gatacagcc  agaaacaag  cttcttcaa  480
tatccagag  atcttgtca  cattaaccc  agcagtatt  ccaaccctc  attttttta  540
ctttcttta  tatacagaa  ccggctctg  attctttac  ctttttgct  atttgatgt  600
tctttacgg  aaccatagg  cttcggcct  gcttgggtt  tgtggcttc  tgtttcgtc  660
gaccaatat  atctgggct  ccttctgtg  aggacacat  attgcacag  agtgcagtg  720
agcctggaa  actgaacta  agaagaaga  ggaagagag  cttcccccg  ctaaaggac  780
gctctcgga  ctcagaaga  ttcttcagt  tctgctgat  tactccatg  cccttaaga  840
cctgagtat  cttttcctt  tgacctggc  ctacatgct  ctgctgttg  catttttcg  900
ttttgtggt  gttaatggt  ggattgtcg  gggtgatcg  agtagtcat  aggcctgcc  960
ccattttcc  cagttgttc  acttcttct  ctttactgc  tttttttcc  ttcctcacc  1020
actttctcc  accaaagtc  agacttttc  tagcttagt  tggaaacgt  gagttcagt  1080
ctctgtgat  actttagtc  cggtatttt  ggtttggaa  ttcacttac  tccataagt  1140
tttactggc  gacaatagg  attacacgt  ttatgtgtg  aaaagagta  ttcagagac  1200
tgaaattgt  aagtattta  tagttccag  ctacatgtt  gctggttgg  ctgtagctg  1260
ctctttaaa  tcaaagtca  ttttctgga  tttaatgtt  tttgtatgc  tggttgctt  1320
tacggttcc  cagaaacta  tagaattcc  ttacttcat  ttaccatac  ttatttata  1380
gctcaacat  cctctgcca  ccatatcta  acttgtttg  gaactgggt  gctatgcag  1440
tgtcaattt  ctaactttt  acatctttc  gaacaagac  tttcagtgg  cggatagtc  1500
tgacatcca  aggtttatg  ggtagtggc  gggctattt  gaactctaa  agcctattt  1560
tacaacaga  gactgggta  aggagtgtg  atttctttt  agtaaattc  gggagacga  1620
aagaattac  tttgaggct  gcctaaaag  ttagataat  ctaataaat  tgcttgcag  1680
tgtcttgag  atcttttca  aagtttggg  attttccgt  tatgtaggg  actgggtga  1740
ctccgtagc  ccagaacct  tcaaccaac  tcctttgta  agaacagtg  agaatgtga  1800
aactgttta  aaataaatg  cctagtggt  tttctgagc  aaattgcca  atattgcag  1860
aaatatagc  ctggtctta  taacttatg  acgagattc  gggatgtct  tctaggaat  1920
gggtatttt  actaagaat  tagaagtga  gaagccatt  gaactaact  cttatttga  1980
ggttttgca  gccgaaggt  agctgtgct  attatgaca  cttttatag  taatctttc  2040
gaaatactg  tctgttagt  gtccagggc  cctgcacaa  actgaccat  aaccttgtg  2100
cttcagagt  ttttctcac  tacgaataa  cagcaccta  actcgagtg  tggcagagc  2160
cctaaactc  agtgctggc  gagctcgct  cttcaggag  caagagttc  ttgttcctg  2220
tcagctcac  ccttagagg  gccttactt  tagacaggt  cctccagtc  gtctgtgtc  2280
gcacaggac  gtctccacc  gcttcttgt  cagttaatg  cattggctt  agggatcct  2340
tgattcagg  taacggtac  tggagaccc  ggattatat  tatcacatt  ttaaagtaa  2400
ttccctttc  gaggtccca  atcattttg  tgtgtgtgt  tgtgtgtgt  tgtgtgtgt  2460
tgtgtgtgt  tgtgtgtgt  tgtaagtaa  atgaccttg  tgagagctt  taagtaaaa  2520
ttagttttt  aaagagagg  caaaaaaca  caacaacaa  acccagatg  ccaaggtca  2580
gtaatttac  tttgtccct  ttatccaaa  aaaccagaa  tcagaaggt  agaggtcat  2640
ggtttagtt  cattttata  tttaggaag  actactagg  tctggggtt  gctttgtct  2700
ggttccggt  ctgtgctgc  gtttaaagt  tgtttattg  ttgtcacca  tgttacaga  2760
actgttgct  agtcctgtg  tgagagtgt  aacacggaa  tgtgacttg  gcttactta  2820
cccacttcc  gagctttac  cacacacac  cacacacac  cacacacac  cacactcac  2880
ccccaaagg  acagaacct  ttattttat  ggataatgt  ttctttgag  tttaaatat  2940
tagtaaact  tatacaact  taaaaacta  ttggataaa  gttacaagc  tagccctgg  3000
tggtcagcc  gcacagacc  ctctgatgc  tcggaggtt  gctcaagtg  aacagtgac  3060
ggtgtgtta  cacatcaga  agcttcatg  cactttatt  tgatagaag  taagtccag  3120
aagcaaaca  ttgcaattg  ataaagcaa  tgctgtctg  tgcttagtc  ctggctttt  3180
tgtctggga  cacagaggg  tggagtgct  catcccagt  gtctgctgt  aggagggaa  3240
cactttgtc  catgtaatg  aaggaggct  ctttcagat  tgttgagtc  cttcagaat  3300
aggagacat  gtaggggtc  acagagaga  agagagaga  agagagaga  agagagaga  3360
agagagaga  agagagaga  agaaaataa  tactggtat  ctacaccac  tcccattat  3420
tattggaag  aggacttgg  atttcagac  gcagtgcca  ggactaaaa  gtgctattt  3480
gttgttact  tgatcttaa  aatggatgc  tgttgatac  tttgaggta  gggtttggt  3540
aatgttgct  gggcagttg  caagttaat  gtcatttgc  gataaattt  tcagtcttt  3600
aactcagta  gtgagagaa  aaggcttca  ccggcggtt  acttttggt  gttcaaatt  3660
acagcccca  ctctgaagt  atttcactt  ggaaaaaaa  ccttgcttt  gcaaatgta  3720
attgtattt  tactttaat  tttaaaaag  attatcaag  agttttcat  agacttaat  3780
gatttattg  tcataagag  ctcagtggt  aaaagcttg  gcccccatt  cagggaccc  3840
cgtgtggtt  cttgcccct  gggcagcct  tagggcact  actgcaggc  tccagctct  3900
cagcctcct  aactcatct  ctgtaaaca  actgcccac  gcctacttc  gttaaaaac  3960
ctaaatggt  agtgtagaa  atgtcagct  ctgaagggg  gtggagtgc  agttctcca  4020
cactcttcc  gtggacatt  tagagcctt  atgaagagg  ccaggcttg  ctgagctgc  4080
ctaggctca  tggtcagtt  tagcagctc  gctttctgt  acaatccac  ggcatagac  4140
cacttccca  acacattag  acgagtgtg  gcactgtac  tgcttatat  tacacttcc  4200
tggacagcc  tcccacggc  gcgtctcac  aaaccttgt  gacatagtg  gttgtactt  4260
acacatagt  cataatctt  tacgaggaa  ttctgtgct  atggaccat  tgtgtttgt  4320
gttgtaaaa  acccactgt  aacagtgtg  tttacttac  gggaatagc  taggatatc  4380
gtgatgtat  tctggtgtg  acttacctg  cttggacat  gtgctcatc  cctttgtct  4440
gagaggaga  aagggagtc  cagctttca  ttataactc  tagagagta  acatatatt  4500
taggtcaag  tcaaactgt  ttcaggtaa  atcatatct  agagcagtt  gaaagcctt  4560
aaatgttaa  acaagtgta  ttttaatgt  tacaatatt  tgcatagat  aacttaaga  4620
gtagaaaag  atgcccttg  ttttggttc  acataaaaa  gacagattg  tgaaagaca  4680
gtgcttgtt  ctgatctca  atgagaatg  tatgtttga  ctcttgtta  tacctgggg  4740
gagtcctac  gcatttcaa  aggattcat  ctgtagtac  tatctgtat  ctcataaac  4800
tgctgtttg  tgtatatcg  gtaaatttg  attgaatgg  gttttcaat  tagaaggaa  4860
cagatattc  agaaaagta  catataacc  acttaatct  aggaagcaa  tgtgtttta  4920
actaagcca  cctgaccca  cctctgcct  ttttctgaa  gttattttc  atagtaatg  4980
atttagtca  gcccgttta  tatgcgccg  gtgcaatag  cttgattct  acaatgcca  5040
ttaaatatg  agtcattca  taattacag  aagtttgat  acttgtctt  tacatttca  5100
tcagttaga  acatcttct  tttggtttt  gctctctga  ttacttttc  ttgggtgca  5160
tttaggtat  tgaagtcaa  ggcaaaatg  tgctgagaa  tataaacaa  ttagttaat  5220
atgacataa  tttaatata  cgaaatgat  ccagcacta  attccataa  gtttggaag  5280
tatttctaa  gtaaatttg  tgataatag  tatctaata  tctcttttt  ttatttaaa  5340
tgagatatt  attagtggc  ttctccata  cttagacac  gttaaagca  aagtaggta  5400
ggtatattt  tctttcaaa  aagtaaata  atggaattt  cattcagaa  tttgatcag  5460
tcaatttat  tgagccctg  actttcact  tcttgctca  gatgaataa  aatgaaaag  5520
attacagta  ttgtctttc  caatagtgt  ttgctggtt  acacacaca  acgcactca  5580
actcacact  acacacatc  taaagctga  cttttgcta  tttgtttcg  tatcaaagc  5640
gtactggtc  gacctctca  gttattgtg  gagttacag  tttttaaaa  ccttaggag  5700
cttttagag  aacatgtat  aaatgataa  cgcttaggt  ttattacaa  atgagttgt  5760
gaacaaatt  ttgatgttt  attggaaaa  catagctcc  ataacaaca  gttcttacg  5820
ttatttgaa  gcataatac  ttgctttaa  tgtagatca  tggtcaaca  ataggtttt  5880
actcacaaa  acacccttt  ttaattatg  tgtctcttt  ggggcatag  gctccccta  5940
ataagtttt  tatttactg  aaacatttc  ctgggaaag  gtcagtggc  tgagagagt  6000
gatatggga  agtgtcttt  caagggtct  aaaacctgc  attttaaac  tgagtttat  6060
gtagttcat  ttctttata  tcttcggta  gtcaggttc  agaatctct  gaagtattc  6120
gcctttcat  tattttgtt  ctgaaataa  gtggatgtt  agctttcgt  aagctggtt  6180
ttaaattgt  tcatacacc  agccacagg  ggtgtaaag  ctcagcgca  cagtaatgc  6240
gtgtttacc  acatacgtt  gtgttcctt  gtcaggaga  aagtgtatt  gggtttccc  6300
tgtagtgag  aataggaaa  tactgtgta  tcaaatttg  actgaaatg  ttactaggt  6360
atgacagtg  gctacattt  aacgtattc  tgtaattta  ctttttcta  tagtctgga  6420
taaactttt  atagttttg  attgttttg  accacaaag  tttagaatt  tccaccttc  6480
ttaatgatt  tttgttgtt  aggaagggt  tcataatcc  ggctagcct  gaatttaca  6540
tgtagccaa  aaagacctt  aactcctga  tcttttgcc  ctacctctg  actgctggg  6600
tcccggcat  ccgcaccat  cccagtgta  gcagtgctg  ggagcaaac  cagaactta  6660
ggcagccgg  aagcagtct  ccagctggg  tgtttcctc  agccctgct  cttctactg  6720
ggccgaaaa  gttccctgg  ttccatgaa  tggaaggta  atgtgaaac  aaaagtcat  6780
tgttccatg  ttaaattgt  tctcagatg  cggaaccta  tgcacccgg  catgaaact  6840
tttacctca  agactgggg  atgtttctg  tagtgataa  aggtttgga  acaacctga  6900
ctgtctact  ctgtctcgc  ggttctcag  cctcttgtg  taactgtac  acatacacg  6960
agagactga  gagagggtg  gtttttgtc  catattaga  taagcagaa  gagtatttg  7020
ctaatgtta  aaagtagct  tgtgagctg  ctttatgag  gggcagcct  acgagaatc  7080
ggctcttag  tgcagctga  atggagtag  aggaaggac  ctgagtcta  cttcctttt  7140
gtaacattt  ggaaaacaa  ttccatggg  aatagaact  cactacttt  ctagatcag  7200
cagttgagg  gcatacaga  tgtctcttc  agagcaggc  gtctctccc  ttgtgtcat  7260
acggcctca  cttgttgtg  gaacacaaa  tctacagca  gggctgaag  tgtcagccc  7320
attaacaag  aagtaaaga  ctttgatat  caatagaga  gtagttgcc  aagaattaa  7380
ttctcaaaa  aactttgga  ataaatggt  gttttaaac  gatctgtga  ttttaaata  7440
tcttttctg  aagaatttg  tgtttattt  aaatacgtg  atatatgtt  taaccgttt  7500
ttaaggttt  acattttgt  acattcaaa  cttaagatg  ttgactcta  aattgtgat  7560
catgtcatt  aaactcttg  ataaaccta  ttataagaa  aaaagcgtt  taaatagtt  7620
aaaaaaaa  7628



<210> 8938
<211> 474
<212> PRT
<213> Rattus norvegicus
<308> AAC34249
<400> 8938

Met Ala Gln Leu Glu Gly Tyr Tyr Phe Ser Ala Ala Leu Ser Cys Thr 
  1               5                  10                  15
Phe Leu Val Ser Cys Leu Leu Phe Ser Ala Phe Ser Arg Ala Leu Arg 
             20                  25                  30
Glu Pro Tyr Met Asp Glu Ile Phe His Leu Pro Gln Ala Gln Arg Tyr 
         35                  40                  45
Cys Glu Gly Arg Phe Ser Leu Ser Gln Trp Asp Pro Met Ile Thr Thr 
     50                  55                  60
Leu Pro Gly Leu Tyr Leu Val Ser Val Gly Val Val Lys Pro Ala Ser 
 65                  70                  75                  80
Trp Ile Leu Gly Trp Ser Glu His Val Val Cys Ser Ile Gly Met Leu 
                 85                  90                  95
Arg Phe Val Asn Leu Leu Phe Ser Val Gly Asn Phe Tyr Leu Leu Tyr 
             100                105                110
Leu Leu Phe Arg Lys Ile Gln Pro Arg Asn Lys Ala Ser Ser Ser Ile 
         115                120                125
Gln Arg Ile Leu Ser Thr Leu Thr Leu Ala Val Phe Pro Thr Leu Tyr 
     130                135                140
Phe Phe Asn Phe Leu Tyr Tyr Thr Glu Ala Gly Ser Val Phe Phe Thr 
 145                150                155                160
Leu Phe Ala Tyr Leu Met Cys Leu Tyr Gly Asn His Arg Thr Ser Ala 
                 165                170                175
Leu Leu Gly Phe Cys Gly Phe Met Phe Arg Gln Thr Asn Ile Ile Trp 
             180                185                190
Ala Ala Phe Cys Ala Gly His Ile Ile Ala Gln Lys Cys Ser Glu Ala 
         195                200                205
Trp Lys Thr Glu Leu Gln Lys Lys Lys Glu Glu Arg Leu Pro Pro Ala 
     210                215                220
Lys Gly Pro Leu Ser Glu Leu Arg Arg Val Leu Gln Phe Leu Leu Met 
 225                230                235                240
Tyr Ser Met Ser Leu Lys Asn Leu Ser Met Leu Phe Leu Leu Thr Trp 
                 245                250                255
Pro Tyr Met Leu Leu Leu Leu Ala Phe Phe Val Phe Val Val Val Asn 
             260                265                270
Gly Gly Ile Val Val Gly Asp Arg Ser Ser His Glu Ala Cys Leu His 
         275                280                285
Phe Pro Gln Leu Phe Tyr Phe Phe Ser Phe Thr Ala Phe Phe Ser Phe 
     290                295                300
Pro His Leu Leu Ser Pro Thr Lys Val Lys Thr Phe Leu Ser Leu Val 
 305                310                315                320
Trp Lys Arg Arg Val Gln Phe Ser Val Ile Thr Leu Val Ser Val Phe 
                 325                330                335
Leu Val Trp Lys Phe Thr Tyr Val His Lys Tyr Leu Leu Ala Asp Asn 
             340                345                350
Arg His Tyr Thr Phe Tyr Val Trp Lys Arg Val Phe Gln Arg His Glu 
         355                360                365
Ile Val Lys Tyr Leu Leu Val Pro Ala Tyr Met Phe Ala Gly Trp Ala 
     370                375                380
Val Ala Asp Ser Leu Lys Ser Lys Ser Ile Phe Trp Asn Leu Met Phe 
 385                390                395                400
Phe Val Cys Leu Val Ala Ser Thr Val Pro Gln Lys Leu Leu Glu Phe 
                 405                410                415
Arg Tyr Phe Ile Leu Pro Tyr Ile Ile Tyr Arg Leu Asn Met Pro Leu 
             420                425                430
Pro Pro Ile Ser Arg Leu Val Cys Glu Leu Gly Cys Tyr Ala Val Val 
         435                440                445
Asn Phe Leu Thr Phe Tyr Ile Phe Leu Asn Lys Thr Phe Gln Trp Ser 
     450                455                460
Asp Ser His Asp Ile Gln Arg Phe Met Trp 
 465                470



<210> 8939
<211> 2245
<212> DNA
<213> Homo sapiens
<308> AK023061
<400> 8939

gaccctgtt  ctctagccg  gcagctgca  ggtcactag  cagaaaaac  caagtcata  60
acatgtttt  tcttgaaag  gcagtagtc  gaaaagaaa  gaactgatc  tggacttga  120
gaaacagcc  cagaggtga  agagatagt  gttaacctg  acagcctct  tccagcctc  180
tcacagata  caagggctt  cggaacaag  aacttgtat  ttctgtgca  ctcaaataa  240
attaagaag  tgaacatca  ttgacaaag  gtaaaaaat  actgggagt  gacgggaaa  300
taaactgtc  tttatgaaa  tgtagctta  tccagaaca  cagatttca  aagatacag  360
atcctgttg  tccacaatt  aatttgtcc  acaaaaagc  aatatagta  atagaagtt  420
ccaacactg  agagaagat  aacaaatct  agcatccca  tggagcaga  aacatgttc  480
gaccatcca  agatccaaa  ggcaggttt  atcactcca  ttgacacca  gtacaagcc  540
ggtaatgta  taatcatgg  atcccactt  aaaatgaaa  aaaatgaag  aaaagcaag  600
ggtaatagg  acaagacag  cacaaatat  tcaagccca  gtctcatct  cagcaacaa  660
cagaaattt  gagaagtta  tctatgaca  gattaagta  gtccttggc  gaacaggat  720
cgtttttcc  attttttgc  cccggacca  cttagtgat  gttcaggta  cagcaacca  780
taaacaaca  caacttaaa  tctatttct  ttttccaag  aatgttctt  aaaagcctt  840
attttgata  ataaactgc  aatgttcca  tttttaaaa  catggaaac  ttgtttggg  900
ctcttaagt  taggaaaac  tttggacca  aggctccat  atgacagct  acataaact  960
agacagaaa  tgttgccaa  ccctctgta  taacgttac  atatgccct  tagtaaaga  1020
tattgtcat  ttgcagatg  gtaacctga  tttctgaaa  tcagaacat  tccaagatc  1080
caaaactag  aaatcacag  accaagatt  aagatcaga  ctttctcta  aacagactt  1140
atatttcta  ccagtaccc  atattgtgt  accagagaa  caggggatg  ttattttga  1200
atttatatg  acatacttg  acagtcaaa  atatactca  aaatgatgt  acttgactg  1260
ttgccagtt  atccagtta  cagttcact  aaaataccc  gggaaggaa  ttgtgatta  1320
aaattgtca  tttttggta  ctgaagatc  ctccagtcc  ccctatccc  cccctaaaa  1380
gcacagtga  gtgcttgac  ggtgagcta  aggaaagtt  tctggtatt  ccaaggagc  1440
cccgaatgc  tttaatcct  aaacaagga  agacaaagt  ggatcgata  cgtcagctg  1500
caagaggag  gctcagttc  ccgttgagt  ttctcccag  tcactcctt  ctggaggac  1560
gatctgctg  ttattcatt  atttaataa  tatttcaca  atctcagag  caggaacaa  1620
agactatac  cagtttctt  catgttctg  ggcttgagg  ggtggaaca  gacgagtga  1680
gtctaagga  gggaggacg  ggggacgct  ggacctctc  ggcctctcc  ggggtgggg  1740
caggttggg  accccacct  ggaaaggga  aaatggccc  cacagtagc  ctgcgcctg  1800
ggcaggtgg  agatctcgt  catgtaggg  tctcgcaac  cccggctga  ggcggagaa  1860
aggaggcag  atactaaaa  ggtagctca  ggcggccga  aaatagtaa  cttccagct  1920
cgccattcc  gctcccaca  ccactgccc  agaacctac  cctggaaaa  tctgagcct  1980
gaaacccga  ctggaaact  gggctcgaa  tgggcgcgc  aggcgggac  agccagacg  2040
ggccacata  cggaaggca  aggatgctg  gagagcgcg  atccggaaa  atcgggtcg  2100
tgtttcccg  agtgacggg  ttagataac  gaccggatg  ttaccctct  aatcgcatt  2160
cccggggcg  acaaagtgt  aaaacttcc  gaaggggcg  gtctcggat  tcgccagcg  2220
gggaggtgc  tggcttgct  cttag  2245



<210> 8940
<211> 2399
<212> DNA
<213> Rattus norvegicus
<308> U78517
<400> 8940

cgggtcatc  gcctggttc  gcaatgggc  gccatgtat  gtgatcttc  ccaagaaga  60
gacgtggcc  tggctttcc  ggaggagtt  tatgtgtct  tatcagatg  tgcacggat  120
atggtcgcc  tcaaggagc  gctggctga  ctggagaag  ctgtcaaac  gatctcaga  180
gacgcaaaa  ctccacaga  gaagcacaa  gtgcttttg  agcagttta  tacaggtga  240
gagagggcc  agaagcgtc  gccgattcg  ggctctgat  aagttttgt  caaggtcta  300
tgcattgac  acaccgata  caccatccg  gtgcctgta  ccgcctcgg  gaaagaagt  360
atcagtgca  tagcagaca  acttggctc  ggggaaggc  tgatcattg  caagatgaa  420
tctggagga  aaaaggtgg  gctcaaacc  aatgatgtt  cagtattta  gacgctcac  480
attaatgga  gcctgtttg  ctgcccgcg  gagcaattc  actcactga  tcccttgcc  540
gaacaggag  gcccgacca  tgggacagt  gggacgttt  aactgatga  ctcgaaaga  600
ttggcgtac  agatgacaa  gtatgactg  gaactcttc  actgtgtgc  cgagctgga  660
ctaatctac  acacatttg  aaggcataa  tttaaaaag  ccacagcaa  cttggattt  720
ttcctgagg  gatttaatg  aattcagtt  tgggttgtc  ctgagatct  cctttgttc  780
cagctcagc  agcgtgttc  gcttttgaa  aaatgtatc  agatagcgg  tcactgcaa  840
gagtacaaa  acttgaatt  cttcttcgg  atcgtcatg  ggctcagta  cgtggctga  900
agccgcctg  cattaacat  ggagaaact  ccgagcaag  ttaagaagt  ctatgcgga  960
tttgagagc  taatggatc  ttccagaaa  cacaaggcg  acaggctga  agcagctaa  1020
ctggagccc  ccctcatcc  tttcatgcc  ttgcttatt  aagatatga  atttactca  1080
gaggggaac  agacattca  tgacaatct  gtaaacttt  aaaaaatgc  catgattgc  1140
aatactgcc  gaacggtgc  ctactacag  agccagcca  tcaatccgg  tgctgctca  1200
gctaataag  accatcagg  tgtccggag  tatgtacgg  aattaaatg  gattgacaa  1260
cagagaact  tatcacaga  gtcacacag  ttagagcct  gcaggccat  gacatctgc  1320
gtgcccaga  tgatgctcc  tctccagtc  acaatcttt  aaaagatgc  gtgtatgct  1380
ctactgact  tgttgctac  agagaattc  ccagaatga  caagagaca  ctcctgaga  1440
cccctcggg  ccacatcct  ctttccgac  acacaggag  aggatctgt  ttgtctaac  1500
cggacatgc  gtagcttag  aaccatcag  tgtagtcat  ttcttcacg  ttggcacac  1560
accgcaggc  cacgtgaag  cataacctg  cgaggctac  ccaggcccc  gacatccct  1620
cccaggctg  tgcagcatg  gactgtccc  tggataggt  tgacttgga  tcgctgcaa  1680
gatataatt  aatgatttg  ttacttagc  ccttatttg  ggtctgggt  ctggggagg  1740
tgttgacca  aaaagtcca  attatccat  atgttcctc  atcgtcata  tcttacctc  1800
gaaggaatg  aacctcatc  caacactat  aaacattat  actgttcag  ctgtaattt  1860
ggaatgatc  atagaataa  atgtttaca  tgtaacttt  aaaaactta  aaatcagga  1920
tacacacat  agaattcca  taagaaaca  caaggttct  aatatcgcc  gcgttaaga  1980
agaaagtaa  atttcagaa  agcacaata  acacaaaac  ttttttcaa  ttgaaatat  2040
ttcctgggc  ttaaaaaac  tttccacta  aaatttatt  ttactgatg  aaaaaaaag  2100
atattttct  gacttaaat  ttattacaa  aatcttaat  ttcagcaat  gttttgcac  2160
ttcagatag  ttgtaaata  gttatgcag  caatggtat  gaattattt  tttgctaca  2220
aatagacat  gtgccaaat  attcctttt  atttatttt  ttcagtatg  aattttgga  2280
tacattttt  ctgttttct  aattagact  catttaatg  ataggaatt  tatgtacat  2340
tctcttctg  aaataacag  cagtatctt  attaaatat  cttgacaag  aaaaaaaaa  2399



<210> 8941
<211> 436
<212> PRT
<213> Rattus norvegicus
<308> AAD03423
<400> 8941

Arg Val Ile Arg Leu Val Leu Gln Trp Ala Ala Met Tyr Gly Asp Leu 
  1               5                  10                  15
Leu Gln Glu Asp Asp Val Ala Met Ala Phe Leu Glu Glu Phe Tyr Val 
             20                  25                  30
Ser Val Ser Asp Asp Ala Arg Met Met Val Ala Phe Lys Glu Gln Leu 
         35                  40                  45
Ala Glu Leu Glu Lys Thr Val Lys Gln Ile Ser Glu Asp Ala Lys Ala 
     50                  55                  60
Pro Gln Lys Lys His Lys Val Leu Leu Gln Gln Phe Asn Thr Gly Asp 
 65                  70                  75                  80
Glu Arg Ala Gln Lys Arg Gln Pro Ile Arg Gly Ser Asp Glu Val Leu 
                 85                  90                  95
Phe Lys Val Tyr Cys Ile Asp His Thr Asp Thr Thr Ile Arg Val Pro 
             100                105                110
Val Ala Ala Ser Val Lys Glu Val Ile Ser Ala Val Ala Asp Lys Leu 
         115                120                125
Gly Ser Gly Glu Gly Leu Ile Ile Val Lys Met Asn Ser Gly Gly Glu 
     130                135                140
Lys Val Val Leu Lys Pro Asn Asp Val Ser Val Phe Thr Thr Leu Thr 
 145                150                155                160
Ile Asn Gly Arg Leu Phe Ala Cys Pro Arg Glu Gln Phe Asp Ser Leu 
                 165                170                175
Thr Pro Leu Pro Glu Gln Glu Gly Pro Thr Thr Gly Thr Val Gly Thr 
             180                185                190
Phe Glu Leu Met Ser Ser Lys Asp Leu Ala Tyr Gln Met Thr Thr Tyr 
         195                200                205
Asp Trp Glu Leu Phe Asn Cys Val Leu Glu Leu Glu Leu Ile Tyr His 
     210                215                220
Thr Phe Gly Arg His Asn Phe Lys Lys Thr Thr Ala Asn Leu Asp Leu 
 225                230                235                240
Phe Leu Arg Arg Phe Asn Glu Ile Gln Phe Trp Val Val Thr Glu Ile 
                 245                250                255
Cys Leu Cys Ser Gln Leu Ser Lys Arg Val Gln Leu Leu Lys Lys Cys 
             260                265                270
Ile Lys Ile Ala Ala His Cys Lys Glu Tyr Lys Asn Leu Asn Ser Phe 
         275                280                285
Phe Gly Ile Val Met Gly Leu Ser Asn Val Ala Glu Ser Arg Leu Ala 
     290                295                300
Leu Thr Trp Glu Lys Leu Pro Ser Lys Phe Lys Lys Phe Tyr Ala Glu 
 305                310                315                320
Phe Glu Ser Leu Met Asp Pro Ser Arg Asn His Lys Ala Tyr Arg Leu 
                 325                330                335
Thr Ala Ala Lys Leu Glu Pro Pro Leu Ile Pro Phe Met Pro Leu Leu 
             340                345                350
Ile Lys Asp Met Thr Phe Thr His Glu Gly Asn Lys Thr Phe Ile Asp 
         355                360                365
Asn Leu Val Asn Phe Glu Lys Met Arg Met Ile Ala Asn Thr Ala Arg 
     370                375                380
Thr Val Arg Tyr Tyr Arg Ser Gln Pro Phe Asn Pro Asp Ala Ala Gln 
 385                390                395                400
Ala Asn Lys Asn His Gln Asp Val Arg Ser Tyr Val Arg Gln Leu Asn 
                 405                410                415
Val Ile Asp Asn Gln Arg Thr Leu Ser Gln Met Ser His Arg Leu Glu 
             420                425                430
Pro Arg Arg Pro 
         435



<210> 8942
<211> 4261
<212> DNA
<213> Homo sapiens
<308> XM_002437
<400> 8942

cgggaggag  ggggtccgc  cggcggacg  ggcgggggc  gaggcgcag  cagagcgag  60
gcgggaggt  gccgcagcc  gggacaccg  gcgccgccg  tcaacatgg  cgctgcgca  120
gctgcccat  cttcctcct  tgccgagtg  atcgcctgc  tggataaaa  accactgga  180
cgatccagc  aagatgtgg  tataatctt  actcgactg  aagaagtta  agcttttga  240
aaatttcac  caaatctcc  tcatcagat  tgcttatgt  gttattatg  gaatctgga  300
aagggaata  cattatttc  ccagggtga  attggaaca  actggtatg  tgtcctggc  360
gggtctttg  atgttaaag  atctgagac  agcagtcac  aggatgctg  gaccatctg  420
accctggga  ttgggacgg  ctttggaga  tccattctg  acaacacac  ccgccatgc  480
accatcgtt  ccagggaga  cagtgaact  ctccgcatc  agcagaagg  cttcaaggc  540
ctatgggag  aatatcgac  gtatatggc  ggacttctg  ctcctcctt  tggtgttat  600
gaaacgggc  ctaacaatg  caggattcc  gacaaggag  acacacctc  cattgaacc  660
cacgttcct  ttcgtcctg  taacaccat  accaaggtc  cttcagaga  gatcctcag  720
gctggaaaa  ttttacgaa  tgccattct  tctcgagca  ctcacatga  aagagatag  780
aaataccac  taaagacat  cagacaatg  tgtgtggga  ctgaactgg  ggactggat  840
atgcagcag  caccatgtg  tcactcccg  actcaagct  ttggcatgt  gcaagtcct  900
ttagaagat  gtgttctca  ccacgtgga  caggagcac  atttccaag  caaatattt  960
ttctatcga  ttctggatg  tgagcacga  gatgcccct  tgcctactg  ggaggagaa  1020
aaggagtgt  atgaggagc  ccaggacac  atgctgctg  tgtcacaga  gggccccga  1080
gcccacatg  ggatgatcc  tcgcaaacc  cctggccag  ggactgtgg  tgacctaga  1140
attatctat  aggagcttc  tcatattaa  gccttatcc  atctttcta  cacagtgaa  1200
cgagagtta  caggtgttc  catttttga  tctcacgcc  aaggaggga  tgtgttgtt  1260
aaccagggg  aagaaggta  ctcctggta  attattcta  aaggatcag  gaatgtagt  1320
atttacggc  agggtgtgg  ctgcaccct  catgaagga  atgacttcg  caagttagc  1380
ctagtgaat  atgccccac  agctgcctc  atcgtctta  gagaagata  ctgccattt  1440
ttaagagta  acaaggagg  tttcaaccg  atcctaagg  acgtggagg  gaatacagt  1500
agacttaaa  aacatgacc  agatgtctt  gtgctggag  aggtcccag  agggaacag  1560
gcttctaat  aaggaaact  acagcctca  caaaagtat  ctgtgatgt  aggaacacc  1620
gaaaaaatt  tagagcatt  tctagaaac  atacgcctt  aggcaactt  aaatgaagc  1680
acagattct  ttttaaatg  ctttattat  atgcactgt  tttttatgc  aaataccca  1740
ctttgcccg  cactggtgg  ccactacca  gcacagcct  cacaaggta  agaacagga  1800
aaaatggat  atgccctca  caataagag  cgagtcatc  gcctggttc  acagtgggc  1860
gccatgtat  gagacctcc  gcaagagga  gacgtgtct  tggccttcc  ggaggagtt  1920
tatgtatct  tatcagatg  tgcccggat  attgctgcc  tcaaggagc  actgccaga  1980
ttggagaag  ttgtcaagc  aatctcaga  gatgcaaag  caccacaaa  gaagcacaa  2040
gttcttttg  aacagttca  tacgggcga  gagagagcc  agaagcgcc  gcctatccg  2100
ggctctgat  aagttctgt  taaggtcta  tgcatggac  acacctaca  aaccattcg  2160
gtgccagtg  ccacttcgg  gaaggaagt  atcagtgca  ttgccgaca  gctgggctc  2220
ggggagggc  tgatcatag  caagatgag  tccggagga  aaaaggtgg  gctcaaacc  2280
aatgatgtt  cagtattta  gacgctcac  attaatgga  gcctgtttg  ttgcccgcg  2340
gagcaattc  attcactga  tcccttacc  gaacaggaa  gcccaactg  tggaacagt  2400
ggaactttt  aactgatga  ctccaaaga  ttagcatac  agatgacaa  ttatgattg  2460
gaactcttc  actgcgtgc  tgagctgga  ctaatctat  acacatttg  aaggcataa  2520
tttaaaaag  ccacagcaa  cttggattt  ttcctgagg  gatttaatg  aattcagtt  2580
tgggtcgtc  ctgagatct  cctttgttc  cagctcagc  agcgtgttc  gctattaaa  2640
aaatttatt  agatagcag  ccactgtaa  gagtataaa  atctgaatt  cttttttgc  2700
atcgtcatg  gactaagta  cgttgctgt  agccgcttg  cactaacgt  ggagaaact  2760
ccaagcaag  tcaagaagt  ctatgcgga  tttgaaagt  taatggacc  ttcaaggaa  2820
cacagggcc  acaggctga  agtagctaa  ctggaacct  ctctcatcc  cttcatgcc  2880
ttgctcatt  aagatatga  atttactca  gaggggaac  agacgttca  tgacaatct  2940
gtaaacttt  aaaaaatgc  catgattgc  aatacggcc  gaacagtga  atactacag  3000
agccaaccc  tcaatcctg  tgcagctca  gctaataag  accatcagg  tgtccggag  3060
tatgtacgg  aattaaatg  gattgacaa  cagagaact  tatcacaga  gtcacacag  3120
ttagagcct  gtcgaccat  gacatttca  atgcccaaa  caacagttt  tctccagtc  3180
acaatcttt  aaaaatgcc  tttatgcta  tactgactg  attgccact  gagaattct  3240
caaaacaag  aaaaacaca  cctgagaca  ctcagggct  cattcagct  accagctac  3300
tagcaagag  aggaattat  tgacatgcc  aaagcttac  cactctagc  taggaatcc  3360
cagtttgtg  ctaccctgt  tcatttcca  ttgtgccat  ttctttgct  aagtgttga  3420
taaggccca  gtgaagagt  tggtagaaa  agccttgtc  agagaacta  caagcccct  3480
acatttttt  ctaagagtg  ttatgggat  agatgtgct  caaatggga  agatttgga  3540
aaaatttta  ctcaacatc  tgatttgga  cctggggtt  cgggaaggt  ttgaggaat  3600
tatagaagt  caaattata  gttgtattc  tccatcttc  ttgtcttac  tctgaagga  3660
tagaacctg  ccacattat  atgaaacat  atggctgtt  atgtaattt  gggaggact  3720
gtctgtaat  tctgaatgt  tatagaata  tatttatgt  tacaatgta  cttttcaaa  3780
tttacaaat  aggattata  acataagaa  tccactaag  aatgccaag  ttcttaaat  3840
tgccagcgt  aaagtagaa  ataacattt  agaagagca  aatatgcat  aaacatttt  3900
caaaattga  atattttcc  gggcattaa  aacctttac  attggctac  aatttattg  3960
acctgatga  aacatattt  ctggactta  atgttatta  aaatatctt  attttcagt  4020
attgttttg  actttcaaa  attgtaaat  gttcattca  tcaatggta  ggagttatt  4080
atttgctac  taatagata  tgtgccaaa  aattacttt  tatttattt  atttagtac  4140
taattttga  gtacatttt  tcctgtttt  acaattaga  tacatttaa  gtgtaggaa  4200
tgtatgtat  tatatcttc  gtaaataac  tctagtatc  tcactaaat  taattgtcg  4260
c  4261



<210> 8943
<211> 1011
<212> PRT
<213> Homo sapiens
<308> XP_002437
<400> 8943

Met Val Ala Ala His Ala Ala His Ser Ser Ser Ser Ala Glu Trp Ile 
  1               5                  10                  15
Ala Cys Leu Asp Lys Arg Pro Leu Glu Arg Ser Ser Glu Asp Val Asp 
             20                  25                  30
Ile Ile Phe Thr Arg Leu Lys Glu Val Lys Ala Phe Glu Lys Phe His 
         35                  40                  45
Pro Asn Leu Leu His Gln Ile Cys Leu Cys Gly Tyr Tyr Glu Asn Leu 
     50                  55                  60
Glu Lys Gly Ile Thr Leu Phe Arg Gln Gly Asp Ile Gly Thr Asn Trp 
 65                  70                  75                  80
Tyr Ala Val Leu Ala Gly Ser Leu Asp Val Lys Val Ser Glu Thr Ser 
                 85                  90                  95
Ser His Gln Asp Ala Val Thr Ile Cys Thr Leu Gly Ile Gly Thr Ala 
             100                105                110
Phe Gly Glu Ser Ile Leu Asp Asn Thr Pro Arg His Ala Thr Ile Val 
         115                120                125
Thr Arg Glu Ser Ser Glu Leu Leu Arg Ile Glu Gln Lys Asp Phe Lys 
     130                135                140
Ala Leu Trp Glu Lys Tyr Arg Gln Tyr Met Ala Gly Leu Leu Ala Pro 
 145                150                155                160
Pro Tyr Gly Val Met Glu Thr Gly Ser Asn Asn Asp Arg Ile Pro Asp 
                 165                170                175
Lys Glu Asn Thr Pro Leu Ile Glu Pro His Val Pro Leu Arg Pro Ala 
             180                185                190
Asn Thr Ile Thr Lys Val Pro Ser Glu Lys Ile Leu Arg Ala Gly Lys 
         195                200                205
Ile Leu Arg Asn Ala Ile Leu Ser Arg Ala Pro His Met Ile Arg Asp 
     210                215                220
Arg Lys Tyr His Leu Lys Thr Tyr Arg Gln Cys Cys Val Gly Thr Glu 
 225                230                235                240
Leu Val Asp Trp Met Met Gln Gln Thr Pro Cys Val His Ser Arg Thr 
                 245                250                255
Gln Ala Val Gly Met Trp Gln Val Leu Leu Glu Asp Gly Val Leu Asn 
             260                265                270
His Val Asp Gln Glu His His Phe Gln Asp Lys Tyr Leu Phe Tyr Arg 
         275                280                285
Phe Leu Asp Asp Glu His Glu Asp Ala Pro Leu Pro Thr Glu Glu Glu 
     290                295                300
Lys Lys Glu Cys Asp Glu Glu Leu Gln Asp Thr Met Leu Leu Leu Ser 
 305                310                315                320
Gln Met Gly Pro Asp Ala His Met Arg Met Ile Leu Arg Lys Pro Pro 
                 325                330                335
Gly Gln Arg Thr Val Asp Asp Leu Glu Ile Ile Tyr Glu Glu Leu Leu 
             340                345                350
His Ile Lys Ala Leu Ser His Leu Ser Thr Thr Val Lys Arg Glu Leu 
         355                360                365
Ala Gly Val Leu Ile Phe Glu Ser His Ala Lys Gly Gly Thr Val Leu 
     370                375                380
Phe Asn Gln Gly Glu Glu Gly Thr Ser Trp Tyr Ile Ile Leu Lys Gly 
 385                390                395                400
Ser Val Asn Val Val Ile Tyr Gly Lys Gly Val Val Cys Thr Leu His 
                 405                410                415
Glu Gly Asp Asp Phe Gly Lys Leu Ala Leu Val Asn Asp Ala Pro Arg 
             420                425                430
Ala Ala Ser Ile Val Leu Arg Glu Asp Asn Cys His Phe Leu Arg Val 
         435                440                445
Asp Lys Glu Asp Phe Asn Arg Ile Leu Arg Asp Val Glu Ala Asn Thr 
     450                455                460
Val Arg Leu Lys Glu His Asp Gln Asp Val Leu Val Leu Glu Lys Val 
 465                470                475                480
Pro Ala Gly Asn Arg Ala Ser Asn Gln Gly Asn Ser Gln Pro Gln Gln 
                 485                490                495
Lys Tyr Thr Val Met Ser Gly Thr Pro Glu Lys Ile Leu Glu His Phe 
             500                505                510
Leu Glu Thr Ile Arg Leu Glu Ala Thr Leu Asn Glu Ala Thr Asp Ser 
         515                520                525
Val Leu Asn Asp Phe Ile Met Met His Cys Val Phe Met Pro Asn Thr 
     530                535                540
Gln Leu Cys Pro Ala Leu Val Ala His Tyr His Ala Gln Pro Ser Gln 
 545                550                555                560
Gly Thr Glu Gln Glu Lys Met Asp Tyr Ala Leu Asn Asn Lys Arg Arg 
                 565                570                575
Val Ile Arg Leu Val Leu Gln Trp Ala Ala Met Tyr Gly Asp Leu Leu 
             580                585                590
Gln Glu Asp Asp Val Ser Met Ala Phe Leu Glu Glu Phe Tyr Val Ser 
         595                600                605
Val Ser Asp Asp Ala Arg Met Ile Ala Ala Leu Lys Glu Gln Leu Pro 
     610                615                620
Glu Leu Glu Lys Ile Val Lys Gln Ile Ser Glu Asp Ala Lys Ala Pro 
 625                630                635                640
Gln Lys Lys His Lys Val Leu Leu Gln Gln Phe Asn Thr Gly Asp Glu 
                 645                650                655
Arg Ala Gln Lys Arg Gln Pro Ile Arg Gly Ser Asp Glu Val Leu Phe 
             660                665                670
Lys Val Tyr Cys Met Asp His Thr Tyr Thr Thr Ile Arg Val Pro Val 
         675                680                685
Ala Thr Ser Val Lys Glu Val Ile Ser Ala Val Ala Asp Lys Leu Gly 
     690                695                700
Ser Gly Glu Gly Leu Ile Ile Val Lys Met Ser Ser Gly Gly Glu Lys 
 705                710                715                720
Val Val Leu Lys Pro Asn Asp Val Ser Val Phe Thr Thr Leu Thr Ile 
                 725                730                735
Asn Gly Arg Leu Phe Ala Cys Pro Arg Glu Gln Phe Asp Ser Leu Thr 
             740                745                750
Pro Leu Pro Glu Gln Glu Gly Pro Thr Val Gly Thr Val Gly Thr Phe 
         755                760                765
Glu Leu Met Ser Ser Lys Asp Leu Ala Tyr Gln Met Thr Ile Tyr Asp 
     770                775                780
Trp Glu Leu Phe Asn Cys Val His Glu Leu Glu Leu Ile Tyr His Thr 
 785                790                795                800
Phe Gly Arg His Asn Phe Lys Lys Thr Thr Ala Asn Leu Asp Leu Phe 
                 805                810                815
Leu Arg Arg Phe Asn Glu Ile Gln Phe Trp Val Val Thr Glu Ile Cys 
             820                825                830
Leu Cys Ser Gln Leu Ser Lys Arg Val Gln Leu Leu Lys Lys Phe Ile 
         835                840                845
Lys Ile Ala Ala His Cys Lys Glu Tyr Lys Asn Leu Asn Ser Phe Phe 
     850                855                860
Ala Ile Val Met Gly Leu Ser Asn Val Ala Val Ser Arg Leu Ala Leu 
 865                870                875                880
Thr Trp Glu Lys Leu Pro Ser Lys Phe Lys Lys Phe Tyr Ala Glu Phe 
                 885                890                895
Glu Ser Leu Met Asp Pro Ser Arg Asn His Arg Ala Tyr Arg Leu Thr 
             900                905                910
Val Ala Lys Leu Glu Pro Pro Leu Ile Pro Phe Met Pro Leu Leu Ile 
         915                920                925
Lys Asp Met Thr Phe Thr His Glu Gly Asn Lys Thr Phe Ile Asp Asn 
     930                935                940
Leu Val Asn Phe Glu Lys Met Arg Met Ile Ala Asn Thr Ala Arg Thr 
 945                950                955                960
Val Arg Tyr Tyr Arg Ser Gln Pro Phe Asn Pro Asp Ala Ala Gln Ala 
                 965                970                975
Asn Lys Asn His Gln Asp Val Arg Ser Tyr Val Arg Gln Leu Asn Val 
             980                985                990
Ile Asp Asn Gln Arg Thr Leu Ser Gln Met Ser His Arg Leu Glu Pro 
         995                1000                1005
Arg Arg Pro 
     1010



<210> 8944
<211> 2399
<212> DNA
<213> Rattus norvegicus
<308> U78517
<400> 8944

cgggtcatc  gcctggttc  gcaatgggc  gccatgtat  gtgatcttc  ccaagaaga  60
gacgtggcc  tggctttcc  ggaggagtt  tatgtgtct  tatcagatg  tgcacggat  120
atggtcgcc  tcaaggagc  gctggctga  ctggagaag  ctgtcaaac  gatctcaga  180
gacgcaaaa  ctccacaga  gaagcacaa  gtgcttttg  agcagttta  tacaggtga  240
gagagggcc  agaagcgtc  gccgattcg  ggctctgat  aagttttgt  caaggtcta  300
tgcattgac  acaccgata  caccatccg  gtgcctgta  ccgcctcgg  gaaagaagt  360
atcagtgca  tagcagaca  acttggctc  ggggaaggc  tgatcattg  caagatgaa  420
tctggagga  aaaaggtgg  gctcaaacc  aatgatgtt  cagtattta  gacgctcac  480
attaatgga  gcctgtttg  ctgcccgcg  gagcaattc  actcactga  tcccttgcc  540
gaacaggag  gcccgacca  tgggacagt  gggacgttt  aactgatga  ctcgaaaga  600
ttggcgtac  agatgacaa  gtatgactg  gaactcttc  actgtgtgc  cgagctgga  660
ctaatctac  acacatttg  aaggcataa  tttaaaaag  ccacagcaa  cttggattt  720
ttcctgagg  gatttaatg  aattcagtt  tgggttgtc  ctgagatct  cctttgttc  780
cagctcagc  agcgtgttc  gcttttgaa  aaatgtatc  agatagcgg  tcactgcaa  840
gagtacaaa  acttgaatt  cttcttcgg  atcgtcatg  ggctcagta  cgtggctga  900
agccgcctg  cattaacat  ggagaaact  ccgagcaag  ttaagaagt  ctatgcgga  960
tttgagagc  taatggatc  ttccagaaa  cacaaggcg  acaggctga  agcagctaa  1020
ctggagccc  ccctcatcc  tttcatgcc  ttgcttatt  aagatatga  atttactca  1080
gaggggaac  agacattca  tgacaatct  gtaaacttt  aaaaaatgc  catgattgc  1140
aatactgcc  gaacggtgc  ctactacag  agccagcca  tcaatccgg  tgctgctca  1200
gctaataag  accatcagg  tgtccggag  tatgtacgg  aattaaatg  gattgacaa  1260
cagagaact  tatcacaga  gtcacacag  ttagagcct  gcaggccat  gacatctgc  1320
gtgcccaga  tgatgctcc  tctccagtc  acaatcttt  aaaagatgc  gtgtatgct  1380
ctactgact  tgttgctac  agagaattc  ccagaatga  caagagaca  ctcctgaga  1440
cccctcggg  ccacatcct  ctttccgac  acacaggag  aggatctgt  ttgtctaac  1500
cggacatgc  gtagcttag  aaccatcag  tgtagtcat  ttcttcacg  ttggcacac  1560
accgcaggc  cacgtgaag  cataacctg  cgaggctac  ccaggcccc  gacatccct  1620
cccaggctg  tgcagcatg  gactgtccc  tggataggt  tgacttgga  tcgctgcaa  1680
gatataatt  aatgatttg  ttacttagc  ccttatttg  ggtctgggt  ctggggagg  1740
tgttgacca  aaaagtcca  attatccat  atgttcctc  atcgtcata  tcttacctc  1800
gaaggaatg  aacctcatc  caacactat  aaacattat  actgttcag  ctgtaattt  1860
ggaatgatc  atagaataa  atgtttaca  tgtaacttt  aaaaactta  aaatcagga  1920
tacacacat  agaattcca  taagaaaca  caaggttct  aatatcgcc  gcgttaaga  1980
agaaagtaa  atttcagaa  agcacaata  acacaaaac  ttttttcaa  ttgaaatat  2040
ttcctgggc  ttaaaaaac  tttccacta  aaatttatt  ttactgatg  aaaaaaaag  2100
atattttct  gacttaaat  ttattacaa  aatcttaat  ttcagcaat  gttttgcac  2160
ttcagatag  ttgtaaata  gttatgcag  caatggtat  gaattattt  tttgctaca  2220
aatagacat  gtgccaaat  attcctttt  atttatttt  ttcagtatg  aattttgga  2280
tacattttt  ctgttttct  aattagact  catttaatg  ataggaatt  tatgtacat  2340
tctcttctg  aaataacag  cagtatctt  attaaatat  cttgacaag  aaaaaaaaa  2399



<210> 8945
<211> 436
<212> PRT
<213> Rattus norvegicus
<308> AAD03423
<400> 8945

Arg Val Ile Arg Leu Val Leu Gln Trp Ala Ala Met Tyr Gly Asp Leu 
  1               5                  10                  15
Leu Gln Glu Asp Asp Val Ala Met Ala Phe Leu Glu Glu Phe Tyr Val 
             20                  25                  30
Ser Val Ser Asp Asp Ala Arg Met Met Val Ala Phe Lys Glu Gln Leu 
         35                  40                  45
Ala Glu Leu Glu Lys Thr Val Lys Gln Ile Ser Glu Asp Ala Lys Ala 
     50                  55                  60
Pro Gln Lys Lys His Lys Val Leu Leu Gln Gln Phe Asn Thr Gly Asp 
 65                  70                  75                  80
Glu Arg Ala Gln Lys Arg Gln Pro Ile Arg Gly Ser Asp Glu Val Leu 
                 85                  90                  95
Phe Lys Val Tyr Cys Ile Asp His Thr Asp Thr Thr Ile Arg Val Pro 
             100                105                110
Val Ala Ala Ser Val Lys Glu Val Ile Ser Ala Val Ala Asp Lys Leu 
         115                120                125
Gly Ser Gly Glu Gly Leu Ile Ile Val Lys Met Asn Ser Gly Gly Glu 
     130                135                140
Lys Val Val Leu Lys Pro Asn Asp Val Ser Val Phe Thr Thr Leu Thr 
 145                150                155                160
Ile Asn Gly Arg Leu Phe Ala Cys Pro Arg Glu Gln Phe Asp Ser Leu 
                 165                170                175
Thr Pro Leu Pro Glu Gln Glu Gly Pro Thr Thr Gly Thr Val Gly Thr 
             180                185                190
Phe Glu Leu Met Ser Ser Lys Asp Leu Ala Tyr Gln Met Thr Thr Tyr 
         195                200                205
Asp Trp Glu Leu Phe Asn Cys Val Leu Glu Leu Glu Leu Ile Tyr His 
     210                215                220
Thr Phe Gly Arg His Asn Phe Lys Lys Thr Thr Ala Asn Leu Asp Leu 
 225                230                235                240
Phe Leu Arg Arg Phe Asn Glu Ile Gln Phe Trp Val Val Thr Glu Ile 
                 245                250                255
Cys Leu Cys Ser Gln Leu Ser Lys Arg Val Gln Leu Leu Lys Lys Cys 
             260                265                270
Ile Lys Ile Ala Ala His Cys Lys Glu Tyr Lys Asn Leu Asn Ser Phe 
         275                280                285
Phe Gly Ile Val Met Gly Leu Ser Asn Val Ala Glu Ser Arg Leu Ala 
     290                295                300
Leu Thr Trp Glu Lys Leu Pro Ser Lys Phe Lys Lys Phe Tyr Ala Glu 
 305                310                315                320
Phe Glu Ser Leu Met Asp Pro Ser Arg Asn His Lys Ala Tyr Arg Leu 
                 325                330                335
Thr Ala Ala Lys Leu Glu Pro Pro Leu Ile Pro Phe Met Pro Leu Leu 
             340                345                350
Ile Lys Asp Met Thr Phe Thr His Glu Gly Asn Lys Thr Phe Ile Asp 
         355                360                365
Asn Leu Val Asn Phe Glu Lys Met Arg Met Ile Ala Asn Thr Ala Arg 
     370                375                380
Thr Val Arg Tyr Tyr Arg Ser Gln Pro Phe Asn Pro Asp Ala Ala Gln 
 385                390                395                400
Ala Asn Lys Asn His Gln Asp Val Arg Ser Tyr Val Arg Gln Leu Asn 
                 405                410                415
Val Ile Asp Asn Gln Arg Thr Leu Ser Gln Met Ser His Arg Leu Glu 
             420                425                430
Pro Arg Arg Pro 
         435



<210> 8946
<211> 4261
<212> DNA
<213> Homo sapiens
<308> XM_002437
<400> 8946

cgggaggag  ggggtccgc  cggcggacg  ggcgggggc  gaggcgcag  cagagcgag  60
gcgggaggt  gccgcagcc  gggacaccg  gcgccgccg  tcaacatgg  cgctgcgca  120
gctgcccat  cttcctcct  tgccgagtg  atcgcctgc  tggataaaa  accactgga  180
cgatccagc  aagatgtgg  tataatctt  actcgactg  aagaagtta  agcttttga  240
aaatttcac  caaatctcc  tcatcagat  tgcttatgt  gttattatg  gaatctgga  300
aagggaata  cattatttc  ccagggtga  attggaaca  actggtatg  tgtcctggc  360
gggtctttg  atgttaaag  atctgagac  agcagtcac  aggatgctg  gaccatctg  420
accctggga  ttgggacgg  ctttggaga  tccattctg  acaacacac  ccgccatgc  480
accatcgtt  ccagggaga  cagtgaact  ctccgcatc  agcagaagg  cttcaaggc  540
ctatgggag  aatatcgac  gtatatggc  ggacttctg  ctcctcctt  tggtgttat  600
gaaacgggc  ctaacaatg  caggattcc  gacaaggag  acacacctc  cattgaacc  660
cacgttcct  ttcgtcctg  taacaccat  accaaggtc  cttcagaga  gatcctcag  720
gctggaaaa  ttttacgaa  tgccattct  tctcgagca  ctcacatga  aagagatag  780
aaataccac  taaagacat  cagacaatg  tgtgtggga  ctgaactgg  ggactggat  840
atgcagcag  caccatgtg  tcactcccg  actcaagct  ttggcatgt  gcaagtcct  900
ttagaagat  gtgttctca  ccacgtgga  caggagcac  atttccaag  caaatattt  960
ttctatcga  ttctggatg  tgagcacga  gatgcccct  tgcctactg  ggaggagaa  1020
aaggagtgt  atgaggagc  ccaggacac  atgctgctg  tgtcacaga  gggccccga  1080
gcccacatg  ggatgatcc  tcgcaaacc  cctggccag  ggactgtgg  tgacctaga  1140
attatctat  aggagcttc  tcatattaa  gccttatcc  atctttcta  cacagtgaa  1200
cgagagtta  caggtgttc  catttttga  tctcacgcc  aaggaggga  tgtgttgtt  1260
aaccagggg  aagaaggta  ctcctggta  attattcta  aaggatcag  gaatgtagt  1320
atttacggc  agggtgtgg  ctgcaccct  catgaagga  atgacttcg  caagttagc  1380
ctagtgaat  atgccccac  agctgcctc  atcgtctta  gagaagata  ctgccattt  1440
ttaagagta  acaaggagg  tttcaaccg  atcctaagg  acgtggagg  gaatacagt  1500
agacttaaa  aacatgacc  agatgtctt  gtgctggag  aggtcccag  agggaacag  1560
gcttctaat  aaggaaact  acagcctca  caaaagtat  ctgtgatgt  aggaacacc  1620
gaaaaaatt  tagagcatt  tctagaaac  atacgcctt  aggcaactt  aaatgaagc  1680
acagattct  ttttaaatg  ctttattat  atgcactgt  tttttatgc  aaataccca  1740
ctttgcccg  cactggtgg  ccactacca  gcacagcct  cacaaggta  agaacagga  1800
aaaatggat  atgccctca  caataagag  cgagtcatc  gcctggttc  acagtgggc  1860
gccatgtat  gagacctcc  gcaagagga  gacgtgtct  tggccttcc  ggaggagtt  1920
tatgtatct  tatcagatg  tgcccggat  attgctgcc  tcaaggagc  actgccaga  1980
ttggagaag  ttgtcaagc  aatctcaga  gatgcaaag  caccacaaa  gaagcacaa  2040
gttcttttg  aacagttca  tacgggcga  gagagagcc  agaagcgcc  gcctatccg  2100
ggctctgat  aagttctgt  taaggtcta  tgcatggac  acacctaca  aaccattcg  2160
gtgccagtg  ccacttcgg  gaaggaagt  atcagtgca  ttgccgaca  gctgggctc  2220
ggggagggc  tgatcatag  caagatgag  tccggagga  aaaaggtgg  gctcaaacc  2280
aatgatgtt  cagtattta  gacgctcac  attaatgga  gcctgtttg  ttgcccgcg  2340
gagcaattc  attcactga  tcccttacc  gaacaggaa  gcccaactg  tggaacagt  2400
ggaactttt  aactgatga  ctccaaaga  ttagcatac  agatgacaa  ttatgattg  2460
gaactcttc  actgcgtgc  tgagctgga  ctaatctat  acacatttg  aaggcataa  2520
tttaaaaag  ccacagcaa  cttggattt  ttcctgagg  gatttaatg  aattcagtt  2580
tgggtcgtc  ctgagatct  cctttgttc  cagctcagc  agcgtgttc  gctattaaa  2640
aaatttatt  agatagcag  ccactgtaa  gagtataaa  atctgaatt  cttttttgc  2700
atcgtcatg  gactaagta  cgttgctgt  agccgcttg  cactaacgt  ggagaaact  2760
ccaagcaag  tcaagaagt  ctatgcgga  tttgaaagt  taatggacc  ttcaaggaa  2820
cacagggcc  acaggctga  agtagctaa  ctggaacct  ctctcatcc  cttcatgcc  2880
ttgctcatt  aagatatga  atttactca  gaggggaac  agacgttca  tgacaatct  2940
gtaaacttt  aaaaaatgc  catgattgc  aatacggcc  gaacagtga  atactacag  3000
agccaaccc  tcaatcctg  tgcagctca  gctaataag  accatcagg  tgtccggag  3060
tatgtacgg  aattaaatg  gattgacaa  cagagaact  tatcacaga  gtcacacag  3120
ttagagcct  gtcgaccat  gacatttca  atgcccaaa  caacagttt  tctccagtc  3180
acaatcttt  aaaaatgcc  tttatgcta  tactgactg  attgccact  gagaattct  3240
caaaacaag  aaaaacaca  cctgagaca  ctcagggct  cattcagct  accagctac  3300
tagcaagag  aggaattat  tgacatgcc  aaagcttac  cactctagc  taggaatcc  3360
cagtttgtg  ctaccctgt  tcatttcca  ttgtgccat  ttctttgct  aagtgttga  3420
taaggccca  gtgaagagt  tggtagaaa  agccttgtc  agagaacta  caagcccct  3480
acatttttt  ctaagagtg  ttatgggat  agatgtgct  caaatggga  agatttgga  3540
aaaatttta  ctcaacatc  tgatttgga  cctggggtt  cgggaaggt  ttgaggaat  3600
tatagaagt  caaattata  gttgtattc  tccatcttc  ttgtcttac  tctgaagga  3660
tagaacctg  ccacattat  atgaaacat  atggctgtt  atgtaattt  gggaggact  3720
gtctgtaat  tctgaatgt  tatagaata  tatttatgt  tacaatgta  cttttcaaa  3780
tttacaaat  aggattata  acataagaa  tccactaag  aatgccaag  ttcttaaat  3840
tgccagcgt  aaagtagaa  ataacattt  agaagagca  aatatgcat  aaacatttt  3900
caaaattga  atattttcc  gggcattaa  aacctttac  attggctac  aatttattg  3960
acctgatga  aacatattt  ctggactta  atgttatta  aaatatctt  attttcagt  4020
attgttttg  actttcaaa  attgtaaat  gttcattca  tcaatggta  ggagttatt  4080
atttgctac  taatagata  tgtgccaaa  aattacttt  tatttattt  atttagtac  4140
taattttga  gtacatttt  tcctgtttt  acaattaga  tacatttaa  gtgtaggaa  4200
tgtatgtat  tatatcttc  gtaaataac  tctagtatc  tcactaaat  taattgtcg  4260
c  4261



<210> 8947
<211> 1011
<212> PRT
<213> Homo sapiens
<308> XP_002437
<400> 8947

Met Val Ala Ala His Ala Ala His Ser Ser Ser Ser Ala Glu Trp Ile 
  1               5                  10                  15
Ala Cys Leu Asp Lys Arg Pro Leu Glu Arg Ser Ser Glu Asp Val Asp 
             20                  25                  30
Ile Ile Phe Thr Arg Leu Lys Glu Val Lys Ala Phe Glu Lys Phe His 
         35                  40                  45
Pro Asn Leu Leu His Gln Ile Cys Leu Cys Gly Tyr Tyr Glu Asn Leu 
     50                  55                  60
Glu Lys Gly Ile Thr Leu Phe Arg Gln Gly Asp Ile Gly Thr Asn Trp 
 65                  70                  75                  80
Tyr Ala Val Leu Ala Gly Ser Leu Asp Val Lys Val Ser Glu Thr Ser 
                 85                  90                  95
Ser His Gln Asp Ala Val Thr Ile Cys Thr Leu Gly Ile Gly Thr Ala 
             100                105                110
Phe Gly Glu Ser Ile Leu Asp Asn Thr Pro Arg His Ala Thr Ile Val 
         115                120                125
Thr Arg Glu Ser Ser Glu Leu Leu Arg Ile Glu Gln Lys Asp Phe Lys 
     130                135                140
Ala Leu Trp Glu Lys Tyr Arg Gln Tyr Met Ala Gly Leu Leu Ala Pro 
 145                150                155                160
Pro Tyr Gly Val Met Glu Thr Gly Ser Asn Asn Asp Arg Ile Pro Asp 
                 165                170                175
Lys Glu Asn Thr Pro Leu Ile Glu Pro His Val Pro Leu Arg Pro Ala 
             180                185                190
Asn Thr Ile Thr Lys Val Pro Ser Glu Lys Ile Leu Arg Ala Gly Lys 
         195                200                205
Ile Leu Arg Asn Ala Ile Leu Ser Arg Ala Pro His Met Ile Arg Asp 
     210                215                220
Arg Lys Tyr His Leu Lys Thr Tyr Arg Gln Cys Cys Val Gly Thr Glu 
 225                230                235                240
Leu Val Asp Trp Met Met Gln Gln Thr Pro Cys Val His Ser Arg Thr 
                 245                250                255
Gln Ala Val Gly Met Trp Gln Val Leu Leu Glu Asp Gly Val Leu Asn 
             260                265                270
His Val Asp Gln Glu His His Phe Gln Asp Lys Tyr Leu Phe Tyr Arg 
         275                280                285
Phe Leu Asp Asp Glu His Glu Asp Ala Pro Leu Pro Thr Glu Glu Glu 
     290                295                300
Lys Lys Glu Cys Asp Glu Glu Leu Gln Asp Thr Met Leu Leu Leu Ser 
 305                310                315                320
Gln Met Gly Pro Asp Ala His Met Arg Met Ile Leu Arg Lys Pro Pro 
                 325                330                335
Gly Gln Arg Thr Val Asp Asp Leu Glu Ile Ile Tyr Glu Glu Leu Leu 
             340                345                350
His Ile Lys Ala Leu Ser His Leu Ser Thr Thr Val Lys Arg Glu Leu 
         355                360                365
Ala Gly Val Leu Ile Phe Glu Ser His Ala Lys Gly Gly Thr Val Leu 
     370                375                380
Phe Asn Gln Gly Glu Glu Gly Thr Ser Trp Tyr Ile Ile Leu Lys Gly 
 385                390                395                400
Ser Val Asn Val Val Ile Tyr Gly Lys Gly Val Val Cys Thr Leu His 
                 405                410                415
Glu Gly Asp Asp Phe Gly Lys Leu Ala Leu Val Asn Asp Ala Pro Arg 
             420                425                430
Ala Ala Ser Ile Val Leu Arg Glu Asp Asn Cys His Phe Leu Arg Val 
         435                440                445
Asp Lys Glu Asp Phe Asn Arg Ile Leu Arg Asp Val Glu Ala Asn Thr 
     450                455                460
Val Arg Leu Lys Glu His Asp Gln Asp Val Leu Val Leu Glu Lys Val 
 465                470                475                480
Pro Ala Gly Asn Arg Ala Ser Asn Gln Gly Asn Ser Gln Pro Gln Gln 
                 485                490                495
Lys Tyr Thr Val Met Ser Gly Thr Pro Glu Lys Ile Leu Glu His Phe 
             500                505                510
Leu Glu Thr Ile Arg Leu Glu Ala Thr Leu Asn Glu Ala Thr Asp Ser 
         515                520                525
Val Leu Asn Asp Phe Ile Met Met His Cys Val Phe Met Pro Asn Thr 
     530                535                540
Gln Leu Cys Pro Ala Leu Val Ala His Tyr His Ala Gln Pro Ser Gln 
 545                550                555                560
Gly Thr Glu Gln Glu Lys Met Asp Tyr Ala Leu Asn Asn Lys Arg Arg 
                 565                570                575
Val Ile Arg Leu Val Leu Gln Trp Ala Ala Met Tyr Gly Asp Leu Leu 
             580                585                590
Gln Glu Asp Asp Val Ser Met Ala Phe Leu Glu Glu Phe Tyr Val Ser 
         595                600                605
Val Ser Asp Asp Ala Arg Met Ile Ala Ala Leu Lys Glu Gln Leu Pro 
     610                615                620
Glu Leu Glu Lys Ile Val Lys Gln Ile Ser Glu Asp Ala Lys Ala Pro 
 625                630                635                640
Gln Lys Lys His Lys Val Leu Leu Gln Gln Phe Asn Thr Gly Asp Glu 
                 645                650                655
Arg Ala Gln Lys Arg Gln Pro Ile Arg Gly Ser Asp Glu Val Leu Phe 
             660                665                670
Lys Val Tyr Cys Met Asp His Thr Tyr Thr Thr Ile Arg Val Pro Val 
         675                680                685
Ala Thr Ser Val Lys Glu Val Ile Ser Ala Val Ala Asp Lys Leu Gly 
     690                695                700
Ser Gly Glu Gly Leu Ile Ile Val Lys Met Ser Ser Gly Gly Glu Lys 
 705                710                715                720
Val Val Leu Lys Pro Asn Asp Val Ser Val Phe Thr Thr Leu Thr Ile 
                 725                730                735
Asn Gly Arg Leu Phe Ala Cys Pro Arg Glu Gln Phe Asp Ser Leu Thr 
             740                745                750
Pro Leu Pro Glu Gln Glu Gly Pro Thr Val Gly Thr Val Gly Thr Phe 
         755                760                765
Glu Leu Met Ser Ser Lys Asp Leu Ala Tyr Gln Met Thr Ile Tyr Asp 
     770                775                780
Trp Glu Leu Phe Asn Cys Val His Glu Leu Glu Leu Ile Tyr His Thr 
 785                790                795                800
Phe Gly Arg His Asn Phe Lys Lys Thr Thr Ala Asn Leu Asp Leu Phe 
                 805                810                815
Leu Arg Arg Phe Asn Glu Ile Gln Phe Trp Val Val Thr Glu Ile Cys 
             820                825                830
Leu Cys Ser Gln Leu Ser Lys Arg Val Gln Leu Leu Lys Lys Phe Ile 
         835                840                845
Lys Ile Ala Ala His Cys Lys Glu Tyr Lys Asn Leu Asn Ser Phe Phe 
     850                855                860
Ala Ile Val Met Gly Leu Ser Asn Val Ala Val Ser Arg Leu Ala Leu 
 865                870                875                880
Thr Trp Glu Lys Leu Pro Ser Lys Phe Lys Lys Phe Tyr Ala Glu Phe 
                 885                890                895
Glu Ser Leu Met Asp Pro Ser Arg Asn His Arg Ala Tyr Arg Leu Thr 
             900                905                910
Val Ala Lys Leu Glu Pro Pro Leu Ile Pro Phe Met Pro Leu Leu Ile 
         915                920                925
Lys Asp Met Thr Phe Thr His Glu Gly Asn Lys Thr Phe Ile Asp Asn 
     930                935                940
Leu Val Asn Phe Glu Lys Met Arg Met Ile Ala Asn Thr Ala Arg Thr 
 945                950                955                960
Val Arg Tyr Tyr Arg Ser Gln Pro Phe Asn Pro Asp Ala Ala Gln Ala 
                 965                970                975
Asn Lys Asn His Gln Asp Val Arg Ser Tyr Val Arg Gln Leu Asn Val 
             980                985                990
Ile Asp Asn Gln Arg Thr Leu Ser Gln Met Ser His Arg Leu Glu Pro 
         995                1000                1005
Arg Arg Pro 
     1010



<210> 8948
<211> 936
<212> DNA
<213> Rattus norvegicus
<308> U78977
<400> 8948

caggaacgc  ccggaaagc  cacctgtgc  gtaggggac  gaggcaatg  cgtcagcat  60
atccaggaa  cagactgcg  cgtgggcgt  gagggcaag  aaggaaagc  ggcttcgct  120
gccgcggac  tctccatca  ccagttcaa  catctcggc  ggctactca  ggtgcacgg  180
cggaacagc  acaagcgct  ggcggctct  agccagttc  tcatccaca  gagcctctg  240
atcagtacc  tgcaggccg  cttctcttc  gtgttctac  ttgcatccg  tcctctcta  300
caaggcttc  tgatcatcg  gtattctac  atctacacc  tgtttcccg  gttttccct  360
gtcttggac  aagacgtga  gtcagaagt  gccatgttg  atcctgagc  ctacaagga  420
ctcctcaag  ggcggccac  gtcctacaa  acgttctta  tttgggtgt  aatcagcat  480
tatcaaggg  gcaccatca  gtacggggc  ctgctgctg  tcgagtccg  atttgtaca  540
atcgtggct  tctctttca  gtcactcat  ctcaccgag  tactgatgg  ggcgctcac  600
atccagacg  ggcactggc  catgacagt  gccgagctg  tcagcctgg  ctgctacat  660
gcctccctg  tgttcctcc  cgagttcat  gatgtctac  tcattgcta  cctgtcgtt  720
ctctggaag  tgtccgtca  caccctggt  agctgtctc  ccctctacg  cctcaagta  780
ctgcggaga  ggttctccc  ccccagcta  tccaagctc  cttcataag  tgcaaggcg  840
cagcagggc  tccggtctc  gcgctctcc  tggaggagg  caagttcag  cgcatgacc  900
cctcaggtg  atggcgcag  cacagctgg  acatga  936



<210> 8949
<211> 275
<212> PRT
<213> Rattus norvegicus
<308> AAC05244
<400> 8949

Gln Glu Arg Thr Gly Lys Leu Thr Cys Ala Val Gly Asp Gly Gly Asn 
  1               5                  10                  15
Asp Val Ser Met Ile Gln Glu Ser Asp Cys Gly Val Gly Val Glu Gly 
             20                  25                  30
Lys Glu Gly Lys Gln Ala Ser Leu Ala Ala Asp Phe Ser Ile Thr Gln 
         35                  40                  45
Phe Lys His Leu Gly Arg Leu Leu Met Val His Gly Arg Asn Ser Tyr 
     50                  55                  60
Lys Arg Ser Ala Ala Leu Ser Gln Phe Val Ile His Arg Ser Leu Cys 
 65                  70                  75                  80
Ile Ser Thr Met Gln Ala Val Phe Ser Ser Val Phe Tyr Phe Ala Ser 
                 85                  90                  95
Val Pro Leu Tyr Gln Gly Phe Leu Ile Ile Gly Tyr Ser Thr Ile Tyr 
             100                105                110
Thr Met Phe Pro Val Phe Ser Leu Val Leu Asp Lys Asp Val Lys Ser 
         115                120                125
Glu Val Ala Met Leu Tyr Pro Glu Leu Tyr Lys Asp Leu Leu Lys Gly 
     130                135                140
Arg Pro Leu Ser Tyr Lys Thr Phe Leu Ile Trp Val Leu Ile Ser Ile 
 145                150                155                160
Tyr Gln Gly Ser Thr Ile Met Tyr Gly Ala Leu Leu Leu Phe Glu Ser 
                 165                170                175
Glu Phe Val His Ile Val Ala Ile Ser Phe Thr Ser Leu Ile Leu Thr 
             180                185                190
Glu Leu Leu Met Val Ala Leu Thr Ile Gln Thr Trp His Trp Leu Met 
         195                200                205
Thr Val Ala Glu Leu Leu Ser Leu Ala Cys Tyr Ile Ala Ser Leu Val 
     210                215                220
Phe Leu His Glu Phe Ile Asp Val Tyr Phe Ile Ala Thr Leu Ser Phe 
 225                230                235                240
Leu Trp Lys Val Ser Val Ile Thr Leu Val Ser Cys Leu Pro Leu Tyr 
                 245                250                255
Val Leu Lys Tyr Leu Arg Arg Arg Phe Ser Pro Pro Ser Tyr Ser Lys 
             260                265                270
Leu Thr Ser 
         275



<210> 8950
<211> 7176
<212> DNA
<213> Homo sapiens
<308> AB014511
<400> 8950

gcggatgga  agcaggccc  gcgccgggt  ctgcgagtg  ctgagatgc  gcggtggag  60
ggaggccag  ccccgcact  tctggctgg  gcaccccga  aagagagac  agaggtatc  120
tcggaatgt  atcaacaat  agaagtaca  tttcttcac  tttcttcct  gggtgctgt  180
caaccagtt  aaatacttt  tcaacctct  tttcttact  cttgcctgc  ctcagtttg  240
tcccgaaat  agacttggt  cactctata  ctactgggt  cccctgggc  tcgtgctgg  300
cgtcactgt  atccgtgag  cggtggagg  gatccgatg  tacgtgcgg  acaaggaag  360
caactccca  gtctacagc  ggctcacag  acgaggtac  gttgtgggt  ttgttcttt  420
cactggcag  gaactccgg  gtgtcatga  tacctcaaa  ccccgaagt  agatcggcc  480
gttcgactt  gaagtgaac  gcctcacca  gatcctctt  ggtgccctg  tggtggtct  540
gctggtcat  gttgccctt  agcactttg  aggccgttg  tacctgcag  tcatccgct  600
cctcctctt  ttttccaac  tcatcccca  tagtttgcg  gtgaacctg  acatgggca  660
gatcgtgta  agctgggtg  ttcgaaggg  ctcaaaaat  cccgggacc  tggttcgct  720
cagcacgat  cctgagcag  tgggcagga  ttcgtactt  ctcacagac  agacaggca  780
tcttaccca  aacgagatg  ttttcaaac  gctccatct  ggaacagta  cctacggcc  840
cgactcaat  gacgaagta  aaagccaca  tttcagcat  tacacccag  aatcccagg  900
cccaccggc  cagaagggc  caacgctca  cactaaggt  cggcggacc  tgagcagcc  960
cgtgcacga  gccgtgaag  ccatcgcgc  ctgccacaa  gtgactccc  tgtatgagt  1020
caacggtgt  actgatcag  ctgaggccg  gaagcagta  gaagactcc  gccgcgtat  1080
ccaggcatc  agccccgat  aggtggccc  ggtacagtg  acggaaagt  tgggcttaa  1140
cctggtggg  cgagaccag  cttccatgc  gctgaggac  cctggcgac  agatcctga  1200
cttcaccat  ctacagatc  tccctttca  ctatgaaag  aaacgtatg  gcatcatcg  1260
gcgggatga  tcaactgga  aaattacgt  ttacatgaa  ggagcagat  tggtcatgg  1320
tggcattgt  cagtacaat  actggttgg  ggaagagtg  ggcaacatg  cccgagaag  1380
gctgcgggt  ctcgtggtg  caaagaagt  tcttgcaga  gagcagtat  aggactttg  1440
agcccgcta  gtccaggcc  agctgagtg  gcacgaccg  tccctcaaa  tggccacgg  1500
gatcgagag  ctggagatg  agatggaac  gctgtgcct  acgggcgtg  aggaccagc  1560
gcaggcaga  gtgcggccc  cgctggaga  cctgaggaa  gctggcatc  aggtttgga  1620
gctgacagg  gacaagctg  agacagcta  gtgcacagc  aagaatgca  atctggtga  1680
cagaaacca  gacatccac  tttttcggc  ggtgaccaa  cgcggggag  ctcacctcg  1740
gctgaacgc  ttccgcagg  agcatgatt  tgccctggt  atctcggga  actccctgg  1800
ggtttgcct  aagtactat  agtacgagt  catggagct  gcctgccag  gcccggccg  1860
agtctgctg  cgatgtgcc  ccacccaga  ggcccagat  gtgcgcctg  ttcaggagc  1920
cacgggcaa  ctcacctgt  cagtagggg  cggaggcaa  gacgtcagc  tgattcagg  1980
atctgactg  ggcgtggga  tggaaggaa  ggaaggaaa  caggcttcg  tggctgcag  2040
cttctccat  actcaattt  agcatcttg  ccggttgct  atggtgcat  gccggaaca  2100
ctacaagcg  tcagccgcc  tcagccagt  cgtgattca  aggagcctc  gtatcagca  2160
catgcaggc  gtcttttcc  ccgtgtttt  ctttgcctc  gtccctctc  atcaaggat  2220
cctcatcat  gggtactcc  caatttaca  catgtttcc  gtgttttct  tggtcctgg  2280
caaagatgt  aaatcggaa  ttgccatgc  gtatcctga  ctctacaag  atcttctca  2340
gggacggcc  ttgtcctac  agacattct  aatatgggt  ttgattagc  tctatcaag  2400
gagcaccat  atgtacggg  cgctgctgc  gtttgagtc  gagttcgtg  acatcgtgg  2460
catctcctt  acctcgctg  tcctcaccg  gctgctcat  gtggcgctg  ccatccaga  2520
ctggcactg  ctcatgaca  tggcggagc  gctcagcct  gcctgctac  tcgcctccc  2580
ggtgttctt  cacgagttc  tcgatgtgt  cttcatcgc  accttgtca  tcttgtgga  2640
agtctccgt  atcactctg  tcagctgcc  ccccctcta  gtcctcaag  acctgcgaa  2700
acggttctc  ccccccagc  actcaaagc  cacatcata  gccgtgcgt  cgctggagg  2760
ggccctggt  ttggcgctt  cctgatgga  agagctcaa  ttccattta  attaaccgc  2820
acctgtgga  tttgcagta  ttgctaaca  atgcagttt  aatgggaag  ggctctgcg  2880
ctaaacgga  tcctaacgc  gcatcaacg  gagggaggg  cctgaaaga  acccatctg  2940
gcctgtctg  acccctcgt  cttcatgtt  aggtgaata  gaatatgtt  aagctggtg  3000
ctcagctgg  agatttata  gggtcactg  gcgagcttc  ttatgactt  aattttgtt  3060
tcacatgat  aaagtttct  tgtagctga  ggttgtaga  ggcttgtgt  tgtgtgtgt  3120
tgtgtgtgt  tgtgtgtgt  tgtgttttt  aagagtcct  atgtgtatg  actctttat  3180
tctttcttg  tcttacaaa  aggtgtcag  aaaatagaa  gctcttggt  tcggtttgg  3240
aggaaaaga  agtgacatt  ggtaaaaag  tatccacac  ataatctcc  ttcggaaat  3300
ctcagtatc  tctccagcc  gccctgctt  tccaggtta  actggattc  tgggatcgt  3360
accagtaaa  gagaggaga  ggagagaga  tgtcctaag  ccaatctgt  atccttgat  3420
tgattcagc  tccatagtg  gtgagttaa  ttcacctgc  acctcgtaa  agaatttca  3480
aggtgtgat  ccgctttat  gggacctgg  aacaatcac  aagccagtg  ctgtttgag  3540
aggacctca  acattttca  cagagttgt  ttagcagga  acgtgccac  gaatggccc  3600
taaatgtgt  gacagtgtg  taagagact  aactaattc  ttaggcaac  tggcagatg  3660
gactcagat  ctccaagac  aaagcggaa  ggtcagggg  ctgggactc  tctcttcca  3720
agaagcctg  ttcctgtta  gaggcataa  ggaagatga  cccacaaag  cagaggcat  3780
tttcggaac  acactggtg  cagctttca  aacaaggaa  ccctggtgg  aggacgccc  3840
agctacagc  ttgggatct  ggatctgtt  cactgccgg  agatttcaa  gggaacttg  3900
tgaaaggca  ccagtggtg  agatttctc  cctcccagg  tggactaca  gccggcatg  3960
ttcttataa  gctgtggct  cttgtttca  aggaaggga  tttgcagtc  cgggacgtg  4020
tagagcaag  cattcttgg  ttttcaagt  gcttcttgc  gaagccaca  atgcatgcc  4080
taagggtta  gttggtgga  ctttaagag  caagtgtgg  tgagatctt  gatttgcgt  4140
tacttcttg  tgaatacat  tccttcaaa  cctctgcct  gcgctactt  tgtgtgctt  4200
agagaggta  atcacagcc  ggtttctga  gcctactaa  tcctgctct  ggagagctg  4260
agacacgag  atcagatag  cccttgcct  tggagcact  ttgataagc  tttgtattt  4320
gtgttgtcc  tttaaaatg  tctagaatg  ctttacgtt  caggtactg  ttaattggc  4380
gttgacacc  catctattt  gtcttatga  tctgcagtt  tgcagtact  ttctctatc  4440
gattcagcc  tttctgcca  agggaaaag  tcggcagaa  agatgtatt  agtgaatag  4500
taaggatag  atctttgtc  aaaaatttc  gaaagattg  gcaaatctg  cgtattcat  4560
gagtgagtt  ctgtgtttt  aaaggtgga  gagaaattt  tgctggaag  ttttaagcc  4620
ccgttttct  ggaaatcag  ctgtaacac  ggcaagtct  aagatagtc  cgtttagac  4680
ttgcagatg  tgaacctgg  tctgtaacg  tgggaagtc  taagatagt  ctgtttaga  4740
tttgcaaac  ctgtacctg  ctttgctcg  agattcggg  tgctggctc  tgcaggcag  4800
gcgtgtggg  gcctcgtca  aaagtttta  aggtttcca  cagaagcag  atgaagatg  4860
tctccctgg  cttttcctt  attctcaat  ttgattgag  tgcacaagt  gacttttaa  4920
gccaacgct  aagatactg  ttgacatct  caagggaga  tgctcccag  aggggctga  4980
gaagccata  ttggaagtg  aaggtactc  tcagtgttc  ccacaaacc  ttttactct  5040
ttgtctcag  cgcactggg  cggaggcgg  caagggtga  aagtaccga  actcaagtg  5100
aaactgcca  gtcgttggc  catcccatc  gtgggcagc  ggctgacgc  attcactgg  5160
cggtccctg  acacctagg  atgcacaca  cgtgcttct  agacactgg  gacgcaaag  5220
caggaggat  cagtccggt  agaggacac  atctttacc  gcacaatca  actgtaagc  5280
cagcagaga  ccccagggg  gcctgggta  ttctcggag  tcatcttag  tgtggtggg  5340
aagacaaag  aataagcaa  caagaaact  gagttacta  acaagaaac  ctcctgagt  5400
tgtaaacct  aagcataag  attcagttg  cctttttct  ggttcatca  tctggaaag  5460
acttacata  agcgccatt  acactgtca  ctgggagct  catgggccg  aagtctttg  5520
cagccaatt  aatttgagg  cagagggcc  tgaggtaca  agtcagcac  gtttgaaca  5580
ttttcctga  agcaaaact  acagctccc  gcgccctct  acaacacta  ctatttctg  5640
cagagtaag  acttctatt  ctattttat  attgttcat  tgtcttttg  tgatggttg  5700
gtgacaggg  gaagcagga  ctatttggt  tcttccccc  ccccccacc  cttcctttt  5760
gtctctctt  ttttttctc  aagaaaatc  ccagactag  ttttccatc  tgagtaatt  5820
cttatgtgg  acagttttg  tcctcattt  gaaagcatg  gtgcgcaca  gtgtgttgc  5880
tgtggtgcc  ggtgagaca  gtggcacta  ctccagctg  ttggaaggc  tcccaaggg  5940
gcatcttaa  gttggagca  acctccctt  tccagcccc  ggggccatt  gaccacgtg  6000
tggaactag  attgtaaaa  tcccatccc  gttccactc  cctgaagtg  aaccctttt  6060
tttttgtga  agtaaatct  aaaaatcat  gtctcttta  gaacatttc  tcagtttct  6120
ctctgctga  aatgtaagc  atgctactt  ttaatgtat  ttgaatttt  tgctcattg  6180
aaattgata  gctaatgcc  cccccaccc  ccgccagac  tttcttttt  tactttgtc  6240
tgtttttac  ggggtaggc  gggcatgcg  gcgtgcctt  agggcagca  tttaaacct  6300
tgccaaaat  gcaaatggg  catgtacat  cttctgctc  atcctactt  aacacctat  6360
agctatttt  atctttaac  ttttctgta  gtttgaagt  tgtgggggg  gtgtgtgtg  6420
gtgaaagag  gagagaatg  tgtcatcta  agttttttg  agaattatt  ggttttcat  6480
gcattaaaa  tctatcact  ccagctttg  tttcattta  aaaaatata  aaagagctt  6540
gtaaataca  cacatttta  ttctccccc  tcttttaat  tacagcttt  ttgccactt  6600
tatatactt  aaatattcc  atgaattat  tccagttct  cttggaaaa  aatttggtt  6660
tgaatgaac  tgcaaagca  cctgcagcg  gagcagctc  tccacctgg  gctccgaag  6720
atcttctca  gccaaagcg  cattacccg  gaatctgtc  tctccgcca  agcatggtt  6780
gaggcgcag  ctgttaata  agctgggcc  tgtcagtga  tgttgtgtt  gtggggtca  6840
gtggggggc  tggtatttg  aaaaaaaac  aattatggc  aatttatta  tttgttgca  6900
tggggttaa  tgtaaactc  tgtaagagt  tgtgatttc  tcattggtt  atctctctc  6960
ctgtaatcc  cattgcaaa  tttcaccag  acagcgttt  ttgattaga  gggagctct  7020
gcacagtat  ctttaattt  gcaggaact  ccagatgat  taaattctc  atgctgtga  7080
gacacacat  tgatctttc  tgtttctga  cgactctac  ttcattgtt  gccagcgtg  7140
ctcgttgct  ttgcccaat  aagcttgtg  acgttc  7176



<210> 8951
<211> 1047
<212> PRT
<213> Homo sapiens
<308> O75110
<400> 8951

Met Thr Asp Asn Ile Pro Leu Gln Pro Val Arg Gln Lys Lys Arg Met 
  1               5                  10                  15
Asp Ser Arg Pro Arg Ala Gly Cys Cys Glu Trp Leu Arg Cys Cys Gly 
             20                  25                  30
Gly Gly Glu Ala Arg Pro Arg Thr Val Trp Leu Gly His Pro Glu Lys 
         35                  40                  45
Arg Asp Gln Arg Tyr Pro Arg Asn Val Ile Asn Asn Gln Lys Tyr Asn 
     50                  55                  60
Phe Phe Thr Phe Leu Pro Gly Val Leu Phe Asn Gln Phe Lys Tyr Phe 
 65                  70                  75                  80
Phe Asn Leu Tyr Phe Leu Leu Leu Ala Cys Ser Gln Phe Val Pro Glu 
                 85                  90                  95
Met Arg Leu Gly Ala Leu Tyr Thr Tyr Trp Val Pro Leu Gly Phe Val 
             100                105                110
Leu Ala Val Thr Val Ile Arg Glu Ala Val Glu Glu Ile Arg Cys Tyr 
         115                120                125
Val Arg Asp Lys Glu Val Asn Ser Gln Val Tyr Ser Arg Leu Thr Ala 
     130                135                140
Arg Gly Thr Val Lys Val Lys Ser Ser Asn Ile Gln Val Gly Asp Leu 
 145                150                155                160
Ile Ile Val Glu Lys Asn Gln Arg Val Pro Ala Asp Met Ile Phe Leu 
                 165                170                175
Arg Thr Ser Glu Lys Asn Gly Ser Cys Phe Leu Arg Thr Asp Gln Leu 
             180                185                190
Asp Gly Glu Thr Asp Trp Lys Leu Arg Leu Pro Val Ala Cys Thr Gln 
         195                200                205
Arg Leu Pro Thr Ala Ala Asp Leu Leu Gln Ile Arg Ser Tyr Val Tyr 
     210                215                220
Ala Glu Glu Pro Asn Ile Asp Ile His Asn Phe Val Gly Thr Phe Thr 
 225                230                235                240
Arg Glu Asp Ser Asp Pro Pro Ile Ser Glu Ser Leu Ser Ile Glu Asn 
                 245                250                255
Thr Leu Trp Ala Gly Thr Val Val Ala Ser Gly Thr Val Val Gly Val 
             260                265                270
Val Leu Tyr Thr Gly Arg Glu Leu Arg Ser Val Met Asn Thr Ser Asn 
         275                280                285
Pro Arg Ser Lys Ile Gly Leu Phe Asp Leu Glu Val Asn Cys Leu Thr 
     290                295                300
Lys Ile Leu Phe Gly Ala Leu Val Val Val Ser Leu Val Met Val Ala 
 305                310                315                320
Leu Gln His Phe Ala Gly Arg Trp Tyr Leu Gln Ile Ile Arg Phe Leu 
                 325                330                335
Leu Leu Phe Ser Asn Ile Ile Pro Ile Ser Leu Arg Val Asn Leu Asp 
             340                345                350
Met Gly Lys Ile Val Tyr Ser Trp Val Ile Arg Arg Asp Ser Lys Ile 
         355                360                365
Pro Gly Thr Val Val Arg Ser Ser Thr Ile Pro Glu Gln Leu Gly Arg 
     370                375                380
Ile Ser Tyr Leu Leu Thr Asp Lys Thr Gly Thr Leu Thr Gln Asn Glu 
 385                390                395                400
Met Ile Phe Lys Arg Leu His Leu Gly Thr Val Ala Tyr Gly Leu Asp 
                 405                410                415
Ser Met Asp Glu Val Gln Ser His Ile Phe Ser Ile Tyr Thr Gln Gln 
             420                425                430
Ser Gln Asp Pro Pro Ala Gln Lys Gly Pro Thr Leu Thr Thr Lys Val 
         435                440                445
Arg Arg Thr Met Ser Ser Arg Val His Glu Ala Val Lys Ala Ile Ala 
     450                455                460
Leu Cys His Asn Val Thr Pro Val Tyr Glu Ser Asn Gly Val Thr Asp 
 465                470                475                480
Gln Ala Glu Ala Glu Lys Gln Tyr Glu Asp Ser Cys Arg Val Tyr Gln 
                 485                490                495
Ala Ser Ser Pro Asp Glu Val Ala Leu Val Gln Trp Thr Glu Ser Val 
             500                505                510
Gly Leu Thr Leu Val Gly Arg Asp Gln Ser Ser Met Gln Leu Arg Thr 
         515                520                525
Pro Gly Asp Gln Ile Leu Asn Phe Thr Ile Leu Gln Ile Phe Pro Phe 
     530                535                540
Thr Tyr Glu Ser Lys Arg Met Gly Ile Ile Val Arg Asp Glu Ser Thr 
 545                550                555                560
Gly Glu Ile Thr Phe Tyr Met Lys Gly Ala Asp Val Val Met Ala Gly 
                 565                570                575
Ile Val Gln Tyr Asn Asp Trp Leu Glu Glu Glu Cys Gly Asn Met Ala 
             580                585                590
Arg Glu Gly Leu Arg Val Leu Val Val Ala Lys Lys Ser Leu Ala Glu 
         595                600                605
Glu Gln Tyr Gln Asp Phe Glu Ala Arg Tyr Val Gln Ala Lys Leu Ser 
     610                615                620
Val His Asp Arg Ser Leu Lys Val Ala Thr Val Ile Glu Ser Leu Glu 
 625                630                635                640
Met Glu Met Glu Leu Leu Cys Leu Thr Gly Val Glu Asp Gln Leu Gln 
                 645                650                655
Ala Asp Val Arg Pro Thr Leu Glu Thr Leu Arg Asn Ala Gly Ile Lys 
             660                665                670
Val Trp Met Leu Thr Gly Asp Lys Leu Glu Thr Ala Thr Cys Thr Ala 
         675                680                685
Lys Asn Ala His Leu Val Thr Arg Asn Gln Asp Ile His Val Phe Arg 
     690                695                700
Leu Val Thr Asn Arg Gly Glu Ala His Leu Glu Leu Asn Ala Phe Arg 
 705                710                715                720
Arg Lys His Asp Cys Ala Leu Val Ile Ser Gly Asp Ser Leu Glu Val 
                 725                730                735
Cys Leu Lys Tyr Tyr Glu Tyr Glu Phe Met Glu Leu Ala Cys Gln Cys 
             740                745                750
Pro Ala Val Val Cys Cys Arg Cys Ala Pro Thr Gln Lys Ala Gln Ile 
         755                760                765
Val Arg Leu Leu Gln Glu Arg Thr Gly Lys Leu Thr Cys Ala Val Gly 
     770                775                780
Asp Gly Gly Asn Asp Val Ser Met Ile Gln Glu Ser Asp Cys Gly Val 
 785                790                795                800
Gly Val Glu Gly Lys Glu Gly Lys Gln Ala Ser Leu Ala Ala Asp Phe 
                 805                810                815
Ser Ile Thr Gln Phe Lys His Leu Gly Arg Leu Leu Met Val His Gly 
             820                825                830
Arg Asn Ser Tyr Lys Arg Ser Ala Ala Leu Ser Gln Phe Val Ile His 
         835                840                845
Arg Ser Leu Cys Ile Ser Thr Met Gln Ala Val Phe Ser Ser Val Phe 
     850                855                860
Tyr Phe Ala Ser Val Pro Leu Tyr Gln Gly Phe Leu Ile Ile Gly Tyr 
 865                870                875                880
Ser Thr Ile Tyr Thr Met Phe Pro Val Phe Ser Leu Val Leu Asp Lys 
                 885                890                895
Asp Val Lys Ser Glu Val Ala Met Leu Tyr Pro Glu Leu Tyr Lys Asp 
             900                905                910
Leu Leu Lys Gly Arg Pro Leu Ser Tyr Lys Thr Phe Leu Ile Trp Val 
         915                920                925
Leu Ile Ser Ile Tyr Gln Gly Ser Thr Ile Met Tyr Gly Ala Leu Leu 
     930                935                940
Leu Phe Glu Ser Glu Phe Val His Ile Val Ala Ile Ser Phe Thr Ser 
 945                950                955                960
Leu Ile Leu Thr Glu Leu Leu Met Val Ala Leu Thr Ile Gln Thr Trp 
                 965                970                975
His Trp Leu Met Thr Val Ala Glu Leu Leu Ser Leu Ala Cys Tyr Ile 
             980                985                990
Ala Ser Leu Val Phe Leu His Glu Phe Ile Asp Val Tyr Phe Ile Ala 
         995                1000                1005
Thr Leu Ser Phe Leu Trp Lys Val Ser Val Ile Thr Leu Val Ser Cys 
     1010                1015                1020
Leu Pro Leu Tyr Val Leu Lys Tyr Leu Arg Arg Arg Phe Ser Pro Pro 
 1025                1030                1035                1040
Ser Tyr Ser Lys Leu Thr Ser 
                 1045



<210> 8952
<211> 936
<212> DNA
<213> Rattus norvegicus
<308> U78977
<400> 8952

caggaacgc  ccggaaagc  cacctgtgc  gtaggggac  gaggcaatg  cgtcagcat  60
atccaggaa  cagactgcg  cgtgggcgt  gagggcaag  aaggaaagc  ggcttcgct  120
gccgcggac  tctccatca  ccagttcaa  catctcggc  ggctactca  ggtgcacgg  180
cggaacagc  acaagcgct  ggcggctct  agccagttc  tcatccaca  gagcctctg  240
atcagtacc  tgcaggccg  cttctcttc  gtgttctac  ttgcatccg  tcctctcta  300
caaggcttc  tgatcatcg  gtattctac  atctacacc  tgtttcccg  gttttccct  360
gtcttggac  aagacgtga  gtcagaagt  gccatgttg  atcctgagc  ctacaagga  420
ctcctcaag  ggcggccac  gtcctacaa  acgttctta  tttgggtgt  aatcagcat  480
tatcaaggg  gcaccatca  gtacggggc  ctgctgctg  tcgagtccg  atttgtaca  540
atcgtggct  tctctttca  gtcactcat  ctcaccgag  tactgatgg  ggcgctcac  600
atccagacg  ggcactggc  catgacagt  gccgagctg  tcagcctgg  ctgctacat  660
gcctccctg  tgttcctcc  cgagttcat  gatgtctac  tcattgcta  cctgtcgtt  720
ctctggaag  tgtccgtca  caccctggt  agctgtctc  ccctctacg  cctcaagta  780
ctgcggaga  ggttctccc  ccccagcta  tccaagctc  cttcataag  tgcaaggcg  840
cagcagggc  tccggtctc  gcgctctcc  tggaggagg  caagttcag  cgcatgacc  900
cctcaggtg  atggcgcag  cacagctgg  acatga  936



<210> 8953
<211> 275
<212> PRT
<213> Rattus norvegicus
<308> AAC05244
<400> 8953

Gln Glu Arg Thr Gly Lys Leu Thr Cys Ala Val Gly Asp Gly Gly Asn 
  1               5                  10                  15
Asp Val Ser Met Ile Gln Glu Ser Asp Cys Gly Val Gly Val Glu Gly 
             20                  25                  30
Lys Glu Gly Lys Gln Ala Ser Leu Ala Ala Asp Phe Ser Ile Thr Gln 
         35                  40                  45
Phe Lys His Leu Gly Arg Leu Leu Met Val His Gly Arg Asn Ser Tyr 
     50                  55                  60
Lys Arg Ser Ala Ala Leu Ser Gln Phe Val Ile His Arg Ser Leu Cys 
 65                  70                  75                  80
Ile Ser Thr Met Gln Ala Val Phe Ser Ser Val Phe Tyr Phe Ala Ser 
                 85                  90                  95
Val Pro Leu Tyr Gln Gly Phe Leu Ile Ile Gly Tyr Ser Thr Ile Tyr 
             100                105                110
Thr Met Phe Pro Val Phe Ser Leu Val Leu Asp Lys Asp Val Lys Ser 
         115                120                125
Glu Val Ala Met Leu Tyr Pro Glu Leu Tyr Lys Asp Leu Leu Lys Gly 
     130                135                140
Arg Pro Leu Ser Tyr Lys Thr Phe Leu Ile Trp Val Leu Ile Ser Ile 
 145                150                155                160
Tyr Gln Gly Ser Thr Ile Met Tyr Gly Ala Leu Leu Leu Phe Glu Ser 
                 165                170                175
Glu Phe Val His Ile Val Ala Ile Ser Phe Thr Ser Leu Ile Leu Thr 
             180                185                190
Glu Leu Leu Met Val Ala Leu Thr Ile Gln Thr Trp His Trp Leu Met 
         195                200                205
Thr Val Ala Glu Leu Leu Ser Leu Ala Cys Tyr Ile Ala Ser Leu Val 
     210                215                220
Phe Leu His Glu Phe Ile Asp Val Tyr Phe Ile Ala Thr Leu Ser Phe 
 225                230                235                240
Leu Trp Lys Val Ser Val Ile Thr Leu Val Ser Cys Leu Pro Leu Tyr 
                 245                250                255
Val Leu Lys Tyr Leu Arg Arg Arg Phe Ser Pro Pro Ser Tyr Ser Lys 
             260                265                270
Leu Thr Ser 
         275



<210> 8954
<211> 7176
<212> DNA
<213> Homo sapiens
<308> AB014511
<400> 8954

gcggatgga  agcaggccc  gcgccgggt  ctgcgagtg  ctgagatgc  gcggtggag  60
ggaggccag  ccccgcact  tctggctgg  gcaccccga  aagagagac  agaggtatc  120
tcggaatgt  atcaacaat  agaagtaca  tttcttcac  tttcttcct  gggtgctgt  180
caaccagtt  aaatacttt  tcaacctct  tttcttact  cttgcctgc  ctcagtttg  240
tcccgaaat  agacttggt  cactctata  ctactgggt  cccctgggc  tcgtgctgg  300
cgtcactgt  atccgtgag  cggtggagg  gatccgatg  tacgtgcgg  acaaggaag  360
caactccca  gtctacagc  ggctcacag  acgaggtac  gttgtgggt  ttgttcttt  420
cactggcag  gaactccgg  gtgtcatga  tacctcaaa  ccccgaagt  agatcggcc  480
gttcgactt  gaagtgaac  gcctcacca  gatcctctt  ggtgccctg  tggtggtct  540
gctggtcat  gttgccctt  agcactttg  aggccgttg  tacctgcag  tcatccgct  600
cctcctctt  ttttccaac  tcatcccca  tagtttgcg  gtgaacctg  acatgggca  660
gatcgtgta  agctgggtg  ttcgaaggg  ctcaaaaat  cccgggacc  tggttcgct  720
cagcacgat  cctgagcag  tgggcagga  ttcgtactt  ctcacagac  agacaggca  780
tcttaccca  aacgagatg  ttttcaaac  gctccatct  ggaacagta  cctacggcc  840
cgactcaat  gacgaagta  aaagccaca  tttcagcat  tacacccag  aatcccagg  900
cccaccggc  cagaagggc  caacgctca  cactaaggt  cggcggacc  tgagcagcc  960
cgtgcacga  gccgtgaag  ccatcgcgc  ctgccacaa  gtgactccc  tgtatgagt  1020
caacggtgt  actgatcag  ctgaggccg  gaagcagta  gaagactcc  gccgcgtat  1080
ccaggcatc  agccccgat  aggtggccc  ggtacagtg  acggaaagt  tgggcttaa  1140
cctggtggg  cgagaccag  cttccatgc  gctgaggac  cctggcgac  agatcctga  1200
cttcaccat  ctacagatc  tccctttca  ctatgaaag  aaacgtatg  gcatcatcg  1260
gcgggatga  tcaactgga  aaattacgt  ttacatgaa  ggagcagat  tggtcatgg  1320
tggcattgt  cagtacaat  actggttgg  ggaagagtg  ggcaacatg  cccgagaag  1380
gctgcgggt  ctcgtggtg  caaagaagt  tcttgcaga  gagcagtat  aggactttg  1440
agcccgcta  gtccaggcc  agctgagtg  gcacgaccg  tccctcaaa  tggccacgg  1500
gatcgagag  ctggagatg  agatggaac  gctgtgcct  acgggcgtg  aggaccagc  1560
gcaggcaga  gtgcggccc  cgctggaga  cctgaggaa  gctggcatc  aggtttgga  1620
gctgacagg  gacaagctg  agacagcta  gtgcacagc  aagaatgca  atctggtga  1680
cagaaacca  gacatccac  tttttcggc  ggtgaccaa  cgcggggag  ctcacctcg  1740
gctgaacgc  ttccgcagg  agcatgatt  tgccctggt  atctcggga  actccctgg  1800
ggtttgcct  aagtactat  agtacgagt  catggagct  gcctgccag  gcccggccg  1860
agtctgctg  cgatgtgcc  ccacccaga  ggcccagat  gtgcgcctg  ttcaggagc  1920
cacgggcaa  ctcacctgt  cagtagggg  cggaggcaa  gacgtcagc  tgattcagg  1980
atctgactg  ggcgtggga  tggaaggaa  ggaaggaaa  caggcttcg  tggctgcag  2040
cttctccat  actcaattt  agcatcttg  ccggttgct  atggtgcat  gccggaaca  2100
ctacaagcg  tcagccgcc  tcagccagt  cgtgattca  aggagcctc  gtatcagca  2160
catgcaggc  gtcttttcc  ccgtgtttt  ctttgcctc  gtccctctc  atcaaggat  2220
cctcatcat  gggtactcc  caatttaca  catgtttcc  gtgttttct  tggtcctgg  2280
caaagatgt  aaatcggaa  ttgccatgc  gtatcctga  ctctacaag  atcttctca  2340
gggacggcc  ttgtcctac  agacattct  aatatgggt  ttgattagc  tctatcaag  2400
gagcaccat  atgtacggg  cgctgctgc  gtttgagtc  gagttcgtg  acatcgtgg  2460
catctcctt  acctcgctg  tcctcaccg  gctgctcat  gtggcgctg  ccatccaga  2520
ctggcactg  ctcatgaca  tggcggagc  gctcagcct  gcctgctac  tcgcctccc  2580
ggtgttctt  cacgagttc  tcgatgtgt  cttcatcgc  accttgtca  tcttgtgga  2640
agtctccgt  atcactctg  tcagctgcc  ccccctcta  gtcctcaag  acctgcgaa  2700
acggttctc  ccccccagc  actcaaagc  cacatcata  gccgtgcgt  cgctggagg  2760
ggccctggt  ttggcgctt  cctgatgga  agagctcaa  ttccattta  attaaccgc  2820
acctgtgga  tttgcagta  ttgctaaca  atgcagttt  aatgggaag  ggctctgcg  2880
ctaaacgga  tcctaacgc  gcatcaacg  gagggaggg  cctgaaaga  acccatctg  2940
gcctgtctg  acccctcgt  cttcatgtt  aggtgaata  gaatatgtt  aagctggtg  3000
ctcagctgg  agatttata  gggtcactg  gcgagcttc  ttatgactt  aattttgtt  3060
tcacatgat  aaagtttct  tgtagctga  ggttgtaga  ggcttgtgt  tgtgtgtgt  3120
tgtgtgtgt  tgtgtgtgt  tgtgttttt  aagagtcct  atgtgtatg  actctttat  3180
tctttcttg  tcttacaaa  aggtgtcag  aaaatagaa  gctcttggt  tcggtttgg  3240
aggaaaaga  agtgacatt  ggtaaaaag  tatccacac  ataatctcc  ttcggaaat  3300
ctcagtatc  tctccagcc  gccctgctt  tccaggtta  actggattc  tgggatcgt  3360
accagtaaa  gagaggaga  ggagagaga  tgtcctaag  ccaatctgt  atccttgat  3420
tgattcagc  tccatagtg  gtgagttaa  ttcacctgc  acctcgtaa  agaatttca  3480
aggtgtgat  ccgctttat  gggacctgg  aacaatcac  aagccagtg  ctgtttgag  3540
aggacctca  acattttca  cagagttgt  ttagcagga  acgtgccac  gaatggccc  3600
taaatgtgt  gacagtgtg  taagagact  aactaattc  ttaggcaac  tggcagatg  3660
gactcagat  ctccaagac  aaagcggaa  ggtcagggg  ctgggactc  tctcttcca  3720
agaagcctg  ttcctgtta  gaggcataa  ggaagatga  cccacaaag  cagaggcat  3780
tttcggaac  acactggtg  cagctttca  aacaaggaa  ccctggtgg  aggacgccc  3840
agctacagc  ttgggatct  ggatctgtt  cactgccgg  agatttcaa  gggaacttg  3900
tgaaaggca  ccagtggtg  agatttctc  cctcccagg  tggactaca  gccggcatg  3960
ttcttataa  gctgtggct  cttgtttca  aggaaggga  tttgcagtc  cgggacgtg  4020
tagagcaag  cattcttgg  ttttcaagt  gcttcttgc  gaagccaca  atgcatgcc  4080
taagggtta  gttggtgga  ctttaagag  caagtgtgg  tgagatctt  gatttgcgt  4140
tacttcttg  tgaatacat  tccttcaaa  cctctgcct  gcgctactt  tgtgtgctt  4200
agagaggta  atcacagcc  ggtttctga  gcctactaa  tcctgctct  ggagagctg  4260
agacacgag  atcagatag  cccttgcct  tggagcact  ttgataagc  tttgtattt  4320
gtgttgtcc  tttaaaatg  tctagaatg  ctttacgtt  caggtactg  ttaattggc  4380
gttgacacc  catctattt  gtcttatga  tctgcagtt  tgcagtact  ttctctatc  4440
gattcagcc  tttctgcca  agggaaaag  tcggcagaa  agatgtatt  agtgaatag  4500
taaggatag  atctttgtc  aaaaatttc  gaaagattg  gcaaatctg  cgtattcat  4560
gagtgagtt  ctgtgtttt  aaaggtgga  gagaaattt  tgctggaag  ttttaagcc  4620
ccgttttct  ggaaatcag  ctgtaacac  ggcaagtct  aagatagtc  cgtttagac  4680
ttgcagatg  tgaacctgg  tctgtaacg  tgggaagtc  taagatagt  ctgtttaga  4740
tttgcaaac  ctgtacctg  ctttgctcg  agattcggg  tgctggctc  tgcaggcag  4800
gcgtgtggg  gcctcgtca  aaagtttta  aggtttcca  cagaagcag  atgaagatg  4860
tctccctgg  cttttcctt  attctcaat  ttgattgag  tgcacaagt  gacttttaa  4920
gccaacgct  aagatactg  ttgacatct  caagggaga  tgctcccag  aggggctga  4980
gaagccata  ttggaagtg  aaggtactc  tcagtgttc  ccacaaacc  ttttactct  5040
ttgtctcag  cgcactggg  cggaggcgg  caagggtga  aagtaccga  actcaagtg  5100
aaactgcca  gtcgttggc  catcccatc  gtgggcagc  ggctgacgc  attcactgg  5160
cggtccctg  acacctagg  atgcacaca  cgtgcttct  agacactgg  gacgcaaag  5220
caggaggat  cagtccggt  agaggacac  atctttacc  gcacaatca  actgtaagc  5280
cagcagaga  ccccagggg  gcctgggta  ttctcggag  tcatcttag  tgtggtggg  5340
aagacaaag  aataagcaa  caagaaact  gagttacta  acaagaaac  ctcctgagt  5400
tgtaaacct  aagcataag  attcagttg  cctttttct  ggttcatca  tctggaaag  5460
acttacata  agcgccatt  acactgtca  ctgggagct  catgggccg  aagtctttg  5520
cagccaatt  aatttgagg  cagagggcc  tgaggtaca  agtcagcac  gtttgaaca  5580
ttttcctga  agcaaaact  acagctccc  gcgccctct  acaacacta  ctatttctg  5640
cagagtaag  acttctatt  ctattttat  attgttcat  tgtcttttg  tgatggttg  5700
gtgacaggg  gaagcagga  ctatttggt  tcttccccc  ccccccacc  cttcctttt  5760
gtctctctt  ttttttctc  aagaaaatc  ccagactag  ttttccatc  tgagtaatt  5820
cttatgtgg  acagttttg  tcctcattt  gaaagcatg  gtgcgcaca  gtgtgttgc  5880
tgtggtgcc  ggtgagaca  gtggcacta  ctccagctg  ttggaaggc  tcccaaggg  5940
gcatcttaa  gttggagca  acctccctt  tccagcccc  ggggccatt  gaccacgtg  6000
tggaactag  attgtaaaa  tcccatccc  gttccactc  cctgaagtg  aaccctttt  6060
tttttgtga  agtaaatct  aaaaatcat  gtctcttta  gaacatttc  tcagtttct  6120
ctctgctga  aatgtaagc  atgctactt  ttaatgtat  ttgaatttt  tgctcattg  6180
aaattgata  gctaatgcc  cccccaccc  ccgccagac  tttcttttt  tactttgtc  6240
tgtttttac  ggggtaggc  gggcatgcg  gcgtgcctt  agggcagca  tttaaacct  6300
tgccaaaat  gcaaatggg  catgtacat  cttctgctc  atcctactt  aacacctat  6360
agctatttt  atctttaac  ttttctgta  gtttgaagt  tgtgggggg  gtgtgtgtg  6420
gtgaaagag  gagagaatg  tgtcatcta  agttttttg  agaattatt  ggttttcat  6480
gcattaaaa  tctatcact  ccagctttg  tttcattta  aaaaatata  aaagagctt  6540
gtaaataca  cacatttta  ttctccccc  tcttttaat  tacagcttt  ttgccactt  6600
tatatactt  aaatattcc  atgaattat  tccagttct  cttggaaaa  aatttggtt  6660
tgaatgaac  tgcaaagca  cctgcagcg  gagcagctc  tccacctgg  gctccgaag  6720
atcttctca  gccaaagcg  cattacccg  gaatctgtc  tctccgcca  agcatggtt  6780
gaggcgcag  ctgttaata  agctgggcc  tgtcagtga  tgttgtgtt  gtggggtca  6840
gtggggggc  tggtatttg  aaaaaaaac  aattatggc  aatttatta  tttgttgca  6900
tggggttaa  tgtaaactc  tgtaagagt  tgtgatttc  tcattggtt  atctctctc  6960
ctgtaatcc  cattgcaaa  tttcaccag  acagcgttt  ttgattaga  gggagctct  7020
gcacagtat  ctttaattt  gcaggaact  ccagatgat  taaattctc  atgctgtga  7080
gacacacat  tgatctttc  tgtttctga  cgactctac  ttcattgtt  gccagcgtg  7140
ctcgttgct  ttgcccaat  aagcttgtg  acgttc  7176



<210> 8955
<211> 1047
<212> PRT
<213> Homo sapiens
<308> O75110
<400> 8955

Met Thr Asp Asn Ile Pro Leu Gln Pro Val Arg Gln Lys Lys Arg Met 
  1               5                  10                  15
Asp Ser Arg Pro Arg Ala Gly Cys Cys Glu Trp Leu Arg Cys Cys Gly 
             20                  25                  30
Gly Gly Glu Ala Arg Pro Arg Thr Val Trp Leu Gly His Pro Glu Lys 
         35                  40                  45
Arg Asp Gln Arg Tyr Pro Arg Asn Val Ile Asn Asn Gln Lys Tyr Asn 
     50                  55                  60
Phe Phe Thr Phe Leu Pro Gly Val Leu Phe Asn Gln Phe Lys Tyr Phe 
 65                  70                  75                  80
Phe Asn Leu Tyr Phe Leu Leu Leu Ala Cys Ser Gln Phe Val Pro Glu 
                 85                  90                  95
Met Arg Leu Gly Ala Leu Tyr Thr Tyr Trp Val Pro Leu Gly Phe Val 
             100                105                110
Leu Ala Val Thr Val Ile Arg Glu Ala Val Glu Glu Ile Arg Cys Tyr 
         115                120                125
Val Arg Asp Lys Glu Val Asn Ser Gln Val Tyr Ser Arg Leu Thr Ala 
     130                135                140
Arg Gly Thr Val Lys Val Lys Ser Ser Asn Ile Gln Val Gly Asp Leu 
 145                150                155                160
Ile Ile Val Glu Lys Asn Gln Arg Val Pro Ala Asp Met Ile Phe Leu 
                 165                170                175
Arg Thr Ser Glu Lys Asn Gly Ser Cys Phe Leu Arg Thr Asp Gln Leu 
             180                185                190
Asp Gly Glu Thr Asp Trp Lys Leu Arg Leu Pro Val Ala Cys Thr Gln 
         195                200                205
Arg Leu Pro Thr Ala Ala Asp Leu Leu Gln Ile Arg Ser Tyr Val Tyr 
     210                215                220
Ala Glu Glu Pro Asn Ile Asp Ile His Asn Phe Val Gly Thr Phe Thr 
 225                230                235                240
Arg Glu Asp Ser Asp Pro Pro Ile Ser Glu Ser Leu Ser Ile Glu Asn 
                 245                250                255
Thr Leu Trp Ala Gly Thr Val Val Ala Ser Gly Thr Val Val Gly Val 
             260                265                270
Val Leu Tyr Thr Gly Arg Glu Leu Arg Ser Val Met Asn Thr Ser Asn 
         275                280                285
Pro Arg Ser Lys Ile Gly Leu Phe Asp Leu Glu Val Asn Cys Leu Thr 
     290                295                300
Lys Ile Leu Phe Gly Ala Leu Val Val Val Ser Leu Val Met Val Ala 
 305                310                315                320
Leu Gln His Phe Ala Gly Arg Trp Tyr Leu Gln Ile Ile Arg Phe Leu 
                 325                330                335
Leu Leu Phe Ser Asn Ile Ile Pro Ile Ser Leu Arg Val Asn Leu Asp 
             340                345                350
Met Gly Lys Ile Val Tyr Ser Trp Val Ile Arg Arg Asp Ser Lys Ile 
         355                360                365
Pro Gly Thr Val Val Arg Ser Ser Thr Ile Pro Glu Gln Leu Gly Arg 
     370                375                380
Ile Ser Tyr Leu Leu Thr Asp Lys Thr Gly Thr Leu Thr Gln Asn Glu 
 385                390                395                400
Met Ile Phe Lys Arg Leu His Leu Gly Thr Val Ala Tyr Gly Leu Asp 
                 405                410                415
Ser Met Asp Glu Val Gln Ser His Ile Phe Ser Ile Tyr Thr Gln Gln 
             420                425                430
Ser Gln Asp Pro Pro Ala Gln Lys Gly Pro Thr Leu Thr Thr Lys Val 
         435                440                445
Arg Arg Thr Met Ser Ser Arg Val His Glu Ala Val Lys Ala Ile Ala 
     450                455                460
Leu Cys His Asn Val Thr Pro Val Tyr Glu Ser Asn Gly Val Thr Asp 
 465                470                475                480
Gln Ala Glu Ala Glu Lys Gln Tyr Glu Asp Ser Cys Arg Val Tyr Gln 
                 485                490                495
Ala Ser Ser Pro Asp Glu Val Ala Leu Val Gln Trp Thr Glu Ser Val 
             500                505                510
Gly Leu Thr Leu Val Gly Arg Asp Gln Ser Ser Met Gln Leu Arg Thr 
         515                520                525
Pro Gly Asp Gln Ile Leu Asn Phe Thr Ile Leu Gln Ile Phe Pro Phe 
     530                535                540
Thr Tyr Glu Ser Lys Arg Met Gly Ile Ile Val Arg Asp Glu Ser Thr 
 545                550                555                560
Gly Glu Ile Thr Phe Tyr Met Lys Gly Ala Asp Val Val Met Ala Gly 
                 565                570                575
Ile Val Gln Tyr Asn Asp Trp Leu Glu Glu Glu Cys Gly Asn Met Ala 
             580                585                590
Arg Glu Gly Leu Arg Val Leu Val Val Ala Lys Lys Ser Leu Ala Glu 
         595                600                605
Glu Gln Tyr Gln Asp Phe Glu Ala Arg Tyr Val Gln Ala Lys Leu Ser 
     610                615                620
Val His Asp Arg Ser Leu Lys Val Ala Thr Val Ile Glu Ser Leu Glu 
 625                630                635                640
Met Glu Met Glu Leu Leu Cys Leu Thr Gly Val Glu Asp Gln Leu Gln 
                 645                650                655
Ala Asp Val Arg Pro Thr Leu Glu Thr Leu Arg Asn Ala Gly Ile Lys 
             660                665                670
Val Trp Met Leu Thr Gly Asp Lys Leu Glu Thr Ala Thr Cys Thr Ala 
         675                680                685
Lys Asn Ala His Leu Val Thr Arg Asn Gln Asp Ile His Val Phe Arg 
     690                695                700
Leu Val Thr Asn Arg Gly Glu Ala His Leu Glu Leu Asn Ala Phe Arg 
 705                710                715                720
Arg Lys His Asp Cys Ala Leu Val Ile Ser Gly Asp Ser Leu Glu Val 
                 725                730                735
Cys Leu Lys Tyr Tyr Glu Tyr Glu Phe Met Glu Leu Ala Cys Gln Cys 
             740                745                750
Pro Ala Val Val Cys Cys Arg Cys Ala Pro Thr Gln Lys Ala Gln Ile 
         755                760                765
Val Arg Leu Leu Gln Glu Arg Thr Gly Lys Leu Thr Cys Ala Val Gly 
     770                775                780
Asp Gly Gly Asn Asp Val Ser Met Ile Gln Glu Ser Asp Cys Gly Val 
 785                790                795                800
Gly Val Glu Gly Lys Glu Gly Lys Gln Ala Ser Leu Ala Ala Asp Phe 
                 805                810                815
Ser Ile Thr Gln Phe Lys His Leu Gly Arg Leu Leu Met Val His Gly 
             820                825                830
Arg Asn Ser Tyr Lys Arg Ser Ala Ala Leu Ser Gln Phe Val Ile His 
         835                840                845
Arg Ser Leu Cys Ile Ser Thr Met Gln Ala Val Phe Ser Ser Val Phe 
     850                855                860
Tyr Phe Ala Ser Val Pro Leu Tyr Gln Gly Phe Leu Ile Ile Gly Tyr 
 865                870                875                880
Ser Thr Ile Tyr Thr Met Phe Pro Val Phe Ser Leu Val Leu Asp Lys 
                 885                890                895
Asp Val Lys Ser Glu Val Ala Met Leu Tyr Pro Glu Leu Tyr Lys Asp 
             900                905                910
Leu Leu Lys Gly Arg Pro Leu Ser Tyr Lys Thr Phe Leu Ile Trp Val 
         915                920                925
Leu Ile Ser Ile Tyr Gln Gly Ser Thr Ile Met Tyr Gly Ala Leu Leu 
     930                935                940
Leu Phe Glu Ser Glu Phe Val His Ile Val Ala Ile Ser Phe Thr Ser 
 945                950                955                960
Leu Ile Leu Thr Glu Leu Leu Met Val Ala Leu Thr Ile Gln Thr Trp 
                 965                970                975
His Trp Leu Met Thr Val Ala Glu Leu Leu Ser Leu Ala Cys Tyr Ile 
             980                985                990
Ala Ser Leu Val Phe Leu His Glu Phe Ile Asp Val Tyr Phe Ile Ala 
         995                1000                1005
Thr Leu Ser Phe Leu Trp Lys Val Ser Val Ile Thr Leu Val Ser Cys 
     1010                1015                1020
Leu Pro Leu Tyr Val Leu Lys Tyr Leu Arg Arg Arg Phe Ser Pro Pro 
 1025                1030                1035                1040
Ser Tyr Ser Lys Leu Thr Ser 
                 1045



<210> 8956
<211> 2127
<212> DNA
<213> Rattus norvegicus
<308> U79417
<400> 8956

atggccacg  cggccgagc  cttcgagga  ccttttgtg  ccgatgaat  cattgaacg  60
ctcgtgtgg  gaaccccgg  aggtggttc  aggggtgga  ctgaagctt  tgatcctaa  120
aggttatta  aagaatttg  gaatcatat  caagaacta  agataatgg  tgaaaggat  180
caaaggaaa  tagagaagt  agaacagca  tgtcagaag  aggcaaagg  gtttgctaa  240
aaggtacaa  agctgcaga  aagcaacca  gttgctttc  aacatttcc  agaactaga  300
gaacacatt  gctatgtag  taccaaagt  tgtcacctt  gagaccagt  ggaaggggt  360
aacacacct  gacagcgtg  agtggaggc  cagaaattg  tgaaatact  taatgagtt  420
ctagatgga  aattgaaat  tgatgtttt  acaaatcct  aaaagatca  ggaagcagc  480
gacgtcatt  agaaactgc  tctgatcgc  caggagtta  ctttcgata  gttttcaga  540
gtaaaatcc  aaattgcaa  taaatacca  gacttagaa  gccagctga  tcaggagtt  600
accagtgca  aacgaagag  tgaggtctc  cggatgagg  aggtggcag  tgtcctgct  660
cattttaag  gttattccc  ctgtattga  gtttatata  agcagtgcc  ggagggtgc  720
tacttgaga  atgatatat  cgaagacgc  gcaattctc  gtcagcgag  gaacaagca  780
gttggagat  tctttagta  tccagaagc  gtactggct  agcttattc  gaatgtgtt  840
gaagtcaaa  tacagagtt  tgtgaaaga  cagttagaa  aatgtagga  atcggatgc  900
gagcagtat  ttaaaagtc  gtatgatct  tacacaaga  ccaccagtc  ttccagcaa  960
ttgatggag  ttaacttag  tactgataa  cagactttc  tgtctaagc  tatcaaatc  1020
attttcgtt  cctatctgg  gaactatat  gaagtggag  ttggatatt  gaaaagcag  1080
agtgctatg  tcctacagc  ctattatga  tcaaaaaac  accaaaaga  atccattgg  1140
acaggaggt  ttcaagatt  gaaagaaag  attagacaa  gtaccaact  accactggg  1200
ccaagtatt  acacacatg  ggagacttt  ctatctcaa  aagtggtag  taatctttt  1260
caagaaacc  aacaagcct  tgaaagatg  cataggctt  ctgatcctt  tgatttacc  1320
aggaatgcc  ttagaattt  taccattct  gtggaattt  tatgtattg  gcatattga  1380
tatgcttta  aaacggggc  tgctggaat  ccatcatca  attctagga  cgcaaatct  1440
tattttttg  atgttgtac  acaggccaa  actattttt  atctttttg  caaacagtt  1500
aatgatcac  taatgccac  aataagctc  tctcctaag  tgtctgaat  cctccagaa  1560
aagaaggag  taattgagc  gatggagat  aagttggac  ctggcatcg  taggacgtt  1620
aattgtatg  ttggacaga  gaagcacat  ttggctgca  aacaaaaga  aacagattt  1680
aagccagaa  atgaaaaca  tgttttgat  cagtatact  atgcatgtg  aaaggtttg  1740
gcttatgta  gaaaacaag  tgagaagat  aagaattcc  tggatggga  gaatgtgga  1800
acggttctg  tggagctcg  agtacgttt  caccggctt  cttatgagc  tcttcaaca  1860
tattcctac  gttgtatgg  cggcatgct  gcaatttgc  acgttgctg  atatagaaa  1920
tgtgccaaa  acttcaaga  tccaatggt  ttacatctt  ttgatactc  gcatgcact  1980
tgcaatctc  tagtcgttg  tccagataa  ttaaagcaa  tctgctcag  agaacaact  2040
gccaatctg  acaagaaca  actccactc  ttcgtccag  ttcgagctg  ctatagatc  2100
gcccgcctg  ctcggcact  cagctga  2127



<210> 8957
<211> 708
<212> PRT
<213> Rattus norvegicus
<308> AAC53096
<400> 8957

Met Ala Thr Thr Ala Glu Leu Phe Glu Glu Pro Phe Val Ala Asp Glu 
  1               5                  10                  15
Tyr Ile Glu Arg Leu Val Trp Arg Thr Pro Gly Gly Gly Ser Arg Gly 
             20                  25                  30
Gly Pro Glu Ala Phe Asp Pro Lys Arg Leu Leu Glu Glu Phe Val Asn 
         35                  40                  45
His Ile Gln Glu Leu Gln Ile Met Asp Glu Arg Ile Gln Arg Lys Val 
     50                  55                  60
Glu Lys Leu Glu Gln Gln Cys Gln Lys Glu Ala Lys Glu Phe Ala Lys 
 65                  70                  75                  80
Lys Val Gln Glu Leu Gln Lys Ser Asn Gln Val Ala Phe Gln His Phe 
                 85                  90                  95
Gln Glu Leu Asp Glu His Ile Ser Tyr Val Ala Thr Lys Val Cys His 
             100                105                110
Leu Gly Asp Gln Leu Glu Gly Val Asn Thr Pro Arg Gln Arg Ala Val 
         115                120                125
Glu Ala Gln Lys Leu Met Lys Tyr Phe Asn Glu Phe Leu Asp Gly Glu 
     130                135                140
Leu Lys Ser Asp Val Phe Thr Asn Pro Glu Lys Ile Lys Glu Ala Ala 
 145                150                155                160
Asp Val Ile Gln Lys Leu His Leu Ile Ala Gln Glu Leu Pro Phe Asp 
                 165                170                175
Arg Phe Ser Glu Val Lys Ser Lys Ile Ala Ser Lys Tyr His Asp Leu 
             180                185                190
Glu Cys Gln Leu Ile Gln Glu Phe Thr Ser Ala Gln Arg Arg Gly Glu 
         195                200                205
Val Ser Arg Met Arg Glu Val Ala Ala Val Leu Leu His Phe Lys Gly 
     210                215                220
Tyr Ser His Cys Ile Asp Val Tyr Ile Lys Gln Cys Gln Glu Gly Ala 
 225                230                235                240
Tyr Leu Arg Asn Asp Ile Phe Glu Asp Ala Ala Ile Leu Cys Gln Arg 
                 245                250                255
Val Asn Lys Gln Val Gly Asp Ile Phe Ser Asn Pro Glu Ala Val Leu 
             260                265                270
Ala Lys Leu Ile Gln Asn Val Phe Glu Val Lys Leu Gln Ser Phe Val 
         275                280                285
Lys Asp Gln Leu Glu Glu Cys Arg Lys Ser Asp Ala Glu Gln Tyr Leu 
     290                295                300
Lys Ser Leu Tyr Asp Leu Tyr Thr Arg Thr Thr Ser Leu Ser Ser Lys 
 305                310                315                320
Leu Met Glu Phe Asn Leu Gly Thr Asp Lys Gln Thr Phe Leu Ser Lys 
                 325                330                335
Leu Ile Lys Ser Ile Phe Val Ser Tyr Leu Glu Asn Tyr Ile Glu Val 
             340                345                350
Glu Ile Gly Tyr Leu Lys Ser Arg Ser Ala Met Ile Leu Gln Arg Tyr 
         355                360                365
Tyr Asp Ser Lys Asn His Gln Lys Arg Ser Ile Gly Thr Gly Gly Ile 
     370                375                380
Gln Asp Leu Lys Glu Arg Ile Arg Gln Arg Thr Asn Leu Pro Leu Gly 
 385                390                395                400
Pro Ser Ile Asp Thr His Gly Glu Thr Phe Leu Ser Gln Glu Val Val 
                 405                410                415
Val Asn Leu Leu Gln Glu Thr Lys Gln Ala Phe Glu Arg Cys His Arg 
             420                425                430
Leu Ser Asp Pro Ser Asp Leu Pro Arg Asn Ala Phe Arg Ile Phe Thr 
         435                440                445
Ile Leu Val Glu Phe Leu Cys Ile Glu His Ile Asp Tyr Ala Leu Glu 
     450                455                460
Thr Gly Leu Ala Gly Ile Pro Ser Ser Asp Ser Arg Asn Ala Asn Leu 
 465                470                475                480
Tyr Phe Leu Asp Val Val Gln Gln Ala Asn Thr Ile Phe His Leu Phe 
                 485                490                495
Asp Lys Gln Phe Asn Asp His Leu Met Pro Leu Ile Ser Ser Ser Pro 
             500                505                510
Lys Leu Ser Glu Cys Leu Gln Lys Lys Lys Glu Ile Ile Glu Gln Met 
         515                520                525
Glu Met Lys Leu Asp Thr Gly Ile Asp Arg Thr Leu Asn Cys Met Ile 
     530                535                540
Gly Gln Met Lys His Ile Leu Ala Ala Glu Gln Lys Lys Thr Asp Phe 
 545                550                555                560
Lys Pro Glu Asp Glu Asn Asn Val Leu Ile Gln Tyr Thr Asn Ala Cys 
                 565                570                575
Val Lys Val Cys Ala Tyr Val Arg Lys Gln Val Glu Lys Ile Lys Asn 
             580                585                590
Ser Met Asp Gly Lys Asn Val Asp Thr Val Leu Met Glu Leu Gly Val 
         595                600                605
Arg Phe His Arg Leu Thr Tyr Glu His Leu Gln Gln Tyr Ser Tyr Ser 
     610                615                620
Cys Met Gly Gly Met Leu Ala Ile Cys Asp Val Ala Glu Tyr Arg Lys 
 625                630                635                640
Cys Ala Lys Asp Phe Lys Ile Pro Met Val Leu His Leu Phe Asp Thr 
                 645                650                655
Leu His Ala Leu Cys Asn Leu Leu Val Val Ala Pro Asp Asn Leu Lys 
             660                665                670
Gln Val Cys Ser Gly Glu Gln Leu Ala Asn Leu Asp Lys Asn Ile Leu 
         675                680                685
His Ser Phe Val Gln Leu Arg Ala Asp Tyr Arg Ser Ala Arg Leu Ala 
     690                695                700
Arg His Phe Ser 
 705



<210> 8958
<211> 483
<212> DNA
<213> Homo sapiens
<308> BE939943
<400> 8958

tgatagggc  tgcctatat  ttgatattt  cccaccttc  ccgctccag  cttagatgt  60
gagtgtgca  taaggctct  gtacagttt  agcatttca  agacaattt  caagttacc  120
taacattta  ctaaacaaa  gctctcccc  cctttctag  tatttcatt  atctgtttt  180
attctgcag  ctgattttt  tactttttt  atcccatta  agatcagtg  aaattctaa  240
gagaaagaa  cctatttcc  ttcatcaca  tcaatttga  gaatgatat  tttatgata  300
tttcaaagg  ttgtttggt  tcttgtaaa  gattaacca  cacttcttg  gatagaaaa  360
tctccccat  agtatcgat  cttggccca  gtggtaagt  ggtacgctg  ctaattctt  420
ccttcaaat  ttgaatact  gtacatcat  aagacaaat  aaaaaaaga  aacatttta  480
tta  483



<210> 8959
<211> 708
<212> PRT
<213> Homo sapiens
<308> NP_006535
<400> 8959

Met Ala Thr Thr Ala Glu Leu Phe Glu Glu Pro Phe Val Ala Asp Glu 
  1               5                  10                  15
Tyr Ile Glu Arg Leu Val Trp Arg Thr Pro Gly Gly Gly Ser Arg Gly 
             20                  25                  30
Gly Pro Glu Ala Phe Asp Pro Lys Arg Leu Leu Glu Glu Phe Val Asn 
         35                  40                  45
His Ile Gln Glu Leu Gln Ile Met Asp Glu Arg Ile Gln Arg Lys Val 
     50                  55                  60
Glu Lys Leu Glu Gln Gln Cys Gln Lys Glu Ala Lys Glu Phe Ala Lys 
 65                  70                  75                  80
Lys Val Gln Glu Leu Gln Lys Ser Asn Gln Val Ala Phe Gln His Phe 
                 85                  90                  95
Gln Glu Leu Asp Glu His Ile Ser Tyr Val Ala Thr Lys Val Cys His 
             100                105                110
Leu Gly Asp Gln Leu Glu Gly Val Asn Thr Pro Arg Gln Arg Ala Val 
         115                120                125
Glu Ala Gln Lys Leu Met Lys Tyr Phe Asn Glu Phe Leu Asp Gly Glu 
     130                135                140
Leu Lys Ser Asp Val Phe Thr Asn Ser Glu Lys Ile Lys Glu Ala Ala 
 145                150                155                160
Asp Ile Ile Gln Lys Leu His Leu Ile Ala Gln Glu Leu Pro Phe Asp 
                 165                170                175
Arg Phe Ser Glu Val Lys Ser Lys Ile Ala Ser Lys Tyr His Asp Leu 
             180                185                190
Glu Cys Gln Leu Ile Gln Glu Phe Thr Ser Ala Gln Arg Arg Gly Glu 
         195                200                205
Ile Ser Arg Met Arg Glu Val Ala Ala Val Leu Leu His Phe Lys Gly 
     210                215                220
Tyr Ser His Cys Val Asp Val Tyr Ile Lys Gln Cys Gln Glu Gly Ala 
 225                230                235                240
Tyr Leu Arg Asn Asp Ile Phe Glu Asp Ala Gly Ile Leu Cys Gln Arg 
                 245                250                255
Val Asn Lys Gln Val Gly Asp Ile Phe Ser Asn Pro Glu Thr Val Leu 
             260                265                270
Ala Lys Leu Ile Gln Asn Val Phe Glu Ile Lys Leu Gln Ser Phe Val 
         275                280                285
Lys Glu Gln Leu Glu Glu Cys Arg Lys Ser Asp Ala Glu Gln Tyr Leu 
     290                295                300
Lys Asn Leu Tyr Asp Leu Tyr Thr Arg Thr Thr Asn Leu Ser Ser Lys 
 305                310                315                320
Leu Met Glu Phe Asn Leu Gly Thr Asp Lys Gln Thr Phe Leu Ser Lys 
                 325                330                335
Leu Ile Lys Ser Ile Phe Ile Ser Tyr Leu Glu Asn Tyr Ile Glu Val 
             340                345                350
Glu Thr Gly Tyr Leu Lys Ser Arg Ser Ala Met Ile Leu Gln Arg Tyr 
         355                360                365
Tyr Asp Ser Lys Asn His Gln Lys Arg Ser Ile Gly Thr Gly Gly Ile 
     370                375                380
Gln Asp Leu Lys Glu Arg Ile Arg Gln Arg Thr Asn Leu Pro Leu Gly 
 385                390                395                400
Pro Ser Ile Asp Thr His Gly Glu Thr Phe Leu Ser Gln Glu Val Val 
                 405                410                415
Val Asn Leu Leu Gln Glu Thr Lys Gln Ala Phe Glu Arg Cys His Arg 
             420                425                430
Leu Ser Asp Pro Ser Asp Leu Pro Arg Asn Ala Phe Arg Ile Phe Thr 
         435                440                445
Ile Leu Val Glu Phe Leu Cys Ile Glu His Ile Asp Tyr Ala Leu Glu 
     450                455                460
Thr Gly Leu Ala Gly Ile Pro Ser Ser Asp Ser Arg Asn Ala Asn Leu 
 465                470                475                480
Tyr Phe Leu Asp Val Val Gln Gln Ala Asn Thr Ile Phe His Leu Phe 
                 485                490                495
Asp Lys Gln Phe Asn Asp His Leu Met Pro Leu Ile Ser Ser Ser Pro 
             500                505                510
Lys Leu Ser Glu Cys Leu Gln Lys Lys Lys Glu Ile Ile Glu Gln Met 
         515                520                525
Glu Met Lys Leu Asp Thr Gly Ile Asp Arg Thr Leu Asn Cys Met Ile 
     530                535                540
Gly Gln Met Lys His Ile Leu Ala Ala Glu Gln Lys Lys Thr Asp Phe 
 545                550                555                560
Lys Pro Glu Asp Glu Asn Asn Val Leu Ile Gln Tyr Thr Asn Ala Cys 
                 565                570                575
Val Lys Val Cys Ala Tyr Val Arg Lys Gln Val Glu Lys Ile Lys Asn 
             580                585                590
Ser Met Asp Gly Lys Asn Val Asp Thr Val Leu Met Glu Leu Gly Val 
         595                600                605
Arg Phe His Arg Leu Ile Tyr Glu His Leu Gln Gln Tyr Ser Tyr Ser 
     610                615                620
Cys Met Gly Gly Met Leu Ala Ile Cys Asp Val Ala Glu Tyr Arg Lys 
 625                630                635                640
Cys Ala Lys Asp Phe Lys Ile Pro Met Val Leu His Leu Phe Asp Thr 
                 645                650                655
Leu His Ala Leu Cys Asn Leu Leu Val Val Ala Pro Asp Asn Leu Lys 
             660                665                670
Gln Val Cys Ser Gly Glu Gln Leu Ala Asn Leu Asp Lys Asn Ile Leu 
         675                680                685
His Ser Phe Val Gln Leu Arg Ala Asp Tyr Arg Ser Ala Arg Leu Ala 
     690                695                700
Arg His Phe Ser 
 705



<210> 8960
<211> 5952
<212> DNA
<213> Rattus norvegicus
<308> U79568
<400> 8960

atggcgatg  tgcctcctc  aggacctca  agtttcgtt  acttcacaa  acagtccct  60
gccctcatt  aacagcgta  ttctgaaga  aaagccaag  aacacaaag  cgaaaagaa  120
gatgatgag  aagaaggcc  caagcccag  agtgacttg  aagctggga  acagctccc  180
ttcatctat  gagacattc  ccctggaat  gtgtcagag  ccctggagg  cctggaccc  240
tactatgct  acaaaaaaa  ttttatagt  ttgaacaaa  ggaaagcaa  cttccgttt  300
aacgccacc  ctgctttgt  catgctgtc  cccttcagt  ctctaagaa  aatatctat  360
aagatctta  tgcactcct  attcagcat  ctaatcatg  gcacaattc  gacgaactg  420
atattcatg  ccttgagca  ccctccaga  tggaccaaa  atgtagagt  cacttttac  480
gggatatat  cttttgaat  actcataaa  atccttgca  gaggctttt  cgtgggaga  540
ttcaccttc  tccgtgacc  ttggaactg  ctggacttt  ttgtcattg  ttttgcgta  600
ttaacagaa  ttgtaaacc  aggcaatgt  tcagctctt  gaactttca  agtcttgag  660
gctttgaaa  ctatttctg  aatcccagg  ctaaagacc  tcgtggggg  cctgatcca  720
tcagtgaag  agctctctg  cgtcatgat  ctcactgtg  tctgtctca  tgtgtttgc  780
ctaattgga  tacagctgt  tatgggcaa  ttgaagcat  aatgtttca  gaaggaact  840
gaagagaat  aaacattag  aagtatcat  aatactgct  agagtgaag  agaattgaa  900
aaatatttt  attacttgg  gggatccaa  gatgctcta  tctgcggct  cagcacaga  960
tcagggcag  gtccagaag  ctacatctg  gtgaaggct  gcagaaacc  ggattatgg  1020
tacacgagc  ttgacacat  cagctgggc  ttcttggcc  tgtttcggc  aatgactca  1080
gactactgg  agaaccttt  ccaacagac  ctgcgtgct  ctggcaaaa  ctacatgat  1140
ttctttgtc  tggttattt  tctgggctc  ttttacctg  taaacttga  cctggctgt  1200
gtagccatg  cgtatgagg  acagaacca  gccaacatc  aagaagcta  acagaaaga  1260
ttagaattt  agcagatgt  agaccgact  aaaaaggag  aggaagaag  tgaggcgat  1320
gctgcagct  ctgctgagt  cacgagtat  gggcggagc  ggatcatgg  actctctga  1380
agctcttca  aaacctcca  gctgagctc  aagagtgcc  aggagagaa  aaaccgaag  1440
aagaaaaag  aacagaaga  gtccagtgg  gaggaaaag  gtgacgatg  gaagctgtc  1500
aagtcagga  cagaggaaa  catccgaaa  aaaagcttc  atctcggtg  ggaagggca  1560
caccggacc  gggaaaaga  gctgtccac  cccaaccag  cgccactca  cattcgcgg  1620
tccctgttt  ctgccaggc  cagcagcag  acgagtctc  tcagtttta  ggggcgagg  1680
agagatctg  gatctgaga  agaattcgc  gatgatgag  atagcattt  tggagacaa  1740
gagagcaga  ggggttcac  attcgtacc  catagaccc  gggagcggc  cagcagtaa  1800
atcagtcag  ccagtaggt  cccgccagt  ctaccggtg  acgggaaga  gcacagtgc  1860
gtggactgc  atggagtcg  gtcgcttgt  gatggaccc  cagccctca  gctccccaa  1920
ggacagctt  ttccagagg  gataataga  aaggcaact  ccgacgaca  cggcacgac  1980
aatcagatg  gcaaaaaaa  gctctctag  tcttacttc  tgtctgagg  catgctgaa  2040
gacccgcat  tcaggcaaa  ggccatgag  agggcgagc  tactgacca  cactgtgga  2100
gaacttgaa  aatctagac  aaaatgtcc  ccatggtgg  acagatttg  tcacacatt  2160
ttaatctgg  attgctctc  atattggat  aaattcaaa  agctcatct  ttttattgt  2220
atggatcct  ttgtagatc  tgcaattac  atttgcata  ttttaaaca  cttatttat  2280
gctatggag  accacccaa  gactgaaga  ttcaaaaat  tccttgcag  ggggaactt  2340
atctttaca  ggatcttcg  agctgaaat  gtactgaag  taatagcca  ggaccccta  2400
gagtatttc  aagtagggt  gaatatttt  gacagccta  ttgtgacgc  gagtttgat  2460
gagcttttc  tagcagatg  ggaaggatt  tcagttctg  ggtcattca  attgctccg  2520
gtcttcaag  tggcaaagt  ctggcccac  ctgaacatg  tcattaaga  catcggcaa  2580
tcggtgggc  cactgggca  cctgaccct  gtgctggcc  tcatcgtct  catttttgc  2640
gtggtcggc  tgcagctgt  tggaaagag  tacaaggag  gtgtctgca  gatcaatgt  2700
gactgcaag  tgccgcgct  gcacatgaa  gacttcttc  actccttcc  catcgtgtt  2760
cgagtgctg  gtggggagt  gatagagac  atgtgggac  gcatggagg  cgcgggcca  2820
accatgtgc  ttattgttt  catgatggt  atggtgatt  ggaaccttg  ggtcctgaa  2880
ctgtttctg  ctcttttgc  gagttcctt  agttctgac  atcttacag  aattgagga  2940
gacaccgat  caaacaacc  ccagatcgc  gtggccaga  ttaagaggg  aatcaatta  3000
gtgaaacag  ccctgcgtg  attcattct  aaatcattt  ccaaaaagc  aaagggctc  3060
aaggacaca  aacgaacag  agatcccaa  aacaagaaa  aaaactata  ttcaaaccg  3120
acccttgcg  agatgagca  ggatcacaa  ttcctcaaa  aaaaggata  gatcagtgg  3180
tatggcagc  gtctagaca  aagctttat  gatgaaaat  attaccagt  ctttatcca  3240
aaccccagc  tcacagtga  agtgccaat  gcacctggg  agtctgatt  ggagattat  3300
aacacagaa  agcttagca  tgactcaga  agtgactac  gcaaagaga  acggaaccg  3360
tcaagctct  ctgagtgca  cactgttga  aaccctctg  caggagaag  ggaggctga  3420
gcagagccc  taaacgcag  tgagcctga  gcctgcttt  cagatggtt  tgtgaggag  3480
tttccatgc  gccaagtta  tgtagactc  gggaaaggg  aagtttggt  gaccatcag  3540
aagacgtgc  acaggatag  tgaacacag  tggtttgaa  gcttcatcg  tctcatgat  3600
ctgctcagc  gtggagctc  ggcttttga  gatatctat  ttgaaaaga  aaagaccat  3660
aagattatc  tggagtatg  tgacaagat  ttcacctac  tcttcattc  ggaaatgct  3720
ctaaaatgg  tcgcatatg  gtataaaac  tatttcact  atgcctggt  ttggctgga  3780
ttcttaatt  ttgatgtgt  tctagttac  ttagtagcc  acactcttg  ctactcaga  3840
cttggcccc  ttaaatctc  acggacact  agggcccta  gacccctaa  agccttgtc  3900
agatttgaa  gaatgaggg  agtggtcaa  gcactcata  gagcaatcc  ttccatcat  3960
aacgtgctt  tcgtgtgcc  tatattctg  ctaatattt  gcatcatgg  agtcaatct  4020
tttgctggc  agttctatg  gtgtgtcaa  accaccgat  ggtcacgat  tcctacatc  4080
caagttgca  accgttctg  gtgttttgc  ctgatgaac  ttagtggaa  tgtgcgatg  4140
aaaaacctg  aagtaaact  cgacaacgt  gggcttggt  acctgtcgc  gcttcaagt  4200
gcaacattc  agggctgga  ggatattat  tatgcagca  ttgactctg  taatgtaaa  4260
gaacagccg  aatacgaat  cagtctcta  atgtacatt  actttgtca  cttcatcat  4320
ttcggctca  tcttcacgt  gaacctgtt  attggtgtc  tcatagata  tttcaacca  4380
cagaaaaaa  agcttggag  tcaagatat  tttatgaca  aagaacaga  gaaatacta  4440
aatgcaatg  agaagcttg  gtccaaaaa  ccacaaaaa  caattccaa  gccagggaa  4500
aaattccaa  gatgtatat  tgacttagt  acaaaccaa  cttttgata  caccatcat  4560
gttcttata  gcctcaaca  ggtaaccat  atggtagaa  aagaggggc  aactgagta  4620
atggattat  ttttacact  gatcaacat  gtcttcatt  tcctgttca  tggggagtg  4680
gtgctgaag  taatctccc  cagacatta  tacttcact  tgggttgga  catttttga  4740
tttgtggta  tgatcctct  cattgtagg  atgtttctc  ctgagatga  agagaagta  4800
ttcgtgtcc  ctaccctgt  ccgagtcat  cgcctggcc  ggattggac  aatcctacg  4860
ctgatcaaa  gcgccaagg  gatccgcac  ctgctcttt  ctttgatga  gtcccttcc  4920
gcgctgttc  acatcggcc  cctgctttt  ctggtcatg  tcatctacg  catctttgg  4980
atgtccaac  ttgcctacg  taaaaagga  gctggaatt  atgacatgt  caactttga  5040
acttttggc  acagcatga  ctgcttgtt  caaatcacc  cctctgccg  ctgggacgg  5100
ctgctggcc  ccatcctca  cagcgcacc  cccgactgt  accctaaaa  agttcaccc  5160
ggaagttca  tggaagggg  ctgtgggaa  ccatccgtg  ggatttttt  ctttgtcag  5220
tacatcatc  tatccttcc  ggtggtggt  aacatgtac  tcgctgtca  cctggagaa  5280
ttcagcgtc  ccaccgaag  gagcactga  cctctgagt  aggacgact  tgagatgtt  5340
tacgaggtc  gggagaagt  cgaccctga  gccactcag  tcatagagt  ctgcaagct  5400
tctgacttt  cagctgccc  ggatcctcc  ctcctcatc  caaagccaa  caaagtcca  5460
ctcattgcc  tggacctgc  catggtgag  ggagaccgc  tccactgcc  ggacatctt  5520
tttgctttt  caaagcggg  cctgggtga  ggtggagag  tggattctc  tcgttcaca  5580
atggaagaa  ggttcatgt  agccaatcc  tctaaagtg  cctatgaac  catcacgac  5640
acactgaag  gaaaacaag  ggaggtgtc  gcgactatc  ttcagcgtg  ttacagacg  5700
tatcgcctc  gacaacacg  caagaatat  tcgagtata  acataaaag  tggagacag  5760
gatgatgat  tgcccaata  agaagatac  gtttttgat  acgtgaacg  gaactcaag  5820
ccggaaaag  cagatgtaa  tgcctcaac  atctcgcca  cttcctatg  cagtgtcac  5880
aagccagat  aagagaaat  tgaaacaga  aaaacagag  aggaagaca  agagaaaga  5940
gaaagcagg  aa  5952



<210> 8961
<211> 1984
<212> PRT
<213> Rattus norvegicus
<308> AAB50403
<400> 8961

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
  1               5                  10                  15
Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ser Glu Glu Lys Ala 
             20                  25                  30
Lys Glu His Lys Asp Glu Lys Lys Asp Asp Glu Glu Glu Gly Pro Lys 
         35                  40                  45
Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
     50                  55                  60
Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
 65                  70                  75                  80
Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Ala 
                 85                  90                  95
Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
             100                105                110
Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
         115                120                125
Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
     130                135                140
Leu Ser Asn Pro Pro Glu Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
 145                150                155                160
Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg Gly Phe 
                 165                170                175
Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
             180                185                190
Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
         195                200                205
Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
     210                215                220
Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
 225                230                235                240
Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                 245                250                255
Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
             260                265                270
His Lys Cys Phe Arg Lys Glu Leu Glu Glu Asn Glu Thr Leu Glu Ser 
         275                280                285
Ile Met Asn Thr Ala Glu Ser Glu Glu Glu Leu Lys Lys Tyr Phe Tyr 
     290                295                300
Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
 305                310                315                320
Ser Gly Gln Cys Pro Glu Gly Tyr Ile Cys Val Lys Ala Gly Arg Asn 
                 325                330                335
Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
             340                345                350
Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
         355                360                365
Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
     370                375                380
Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
 385                390                395                400
Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                 405                410                415
Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
             420                425                430
Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Phe Thr 
         435                440                445
Ser Ile Gly Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
     450                455                460
Thr Ser Arg Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
 465                470                475                480
Lys Lys Lys Lys Gln Lys Met Ser Ser Gly Glu Glu Lys Gly Asp Asp 
                 485                490                495
Glu Lys Leu Ser Lys Ser Gly Ser Glu Glu Ser Ile Arg Lys Lys Ser 
             500                505                510
Phe His Leu Gly Val Glu Gly His His Arg Thr Arg Glu Lys Arg Leu 
         515                520                525
Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe Ser 
     530                535                540
Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg Gly 
 545                550                555                560
Arg Asp Leu Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser Ile 
                 565                570                575
Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His Arg 
             580                585                590
Pro Arg Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser Pro 
         595                600                605
Pro Val Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys Asn 
     610                615                620
Gly Val Val Ser Leu Val Asp Gly Pro Ser Ala Leu Met Leu Pro Asn 
 625                630                635                640
Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp Asp 
                 645                650                655
Ser Gly Thr Thr Asn Gln Met Arg Lys Lys Arg Leu Ser Ser Ser Tyr 
             660                665                670
Phe Leu Ser Glu Asp Met Leu Asn Asp Pro His Leu Arg Gln Arg Ala 
         675                680                685
Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu Glu 
     690                695                700
Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Thr Phe 
 705                710                715                720
Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Leu Ile 
                 725                730                735
Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
             740                745                750
Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr 
         755                760                765
Glu Glu Phe Lys Asn Val Leu Ala Val Gly Asn Leu Ile Phe Thr Gly 
     770                775                780
Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr 
 785                790                795                800
Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 
                 805                810                815
Leu Ser Leu Ile Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 
             820                825                830
Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
         835                840                845
Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
     850                855                860
Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
 865                870                875                880
Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
                 885                890                895
Lys Ile Asn Val Asp Cys Lys Leu Pro Arg Trp His Met Asn Asp Phe 
             900                905                910
Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
         915                920                925
Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
     930                935                940
Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
 945                950                955                960
Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Thr 
                 965                970                975
Ala Ile Glu Glu Asp Thr Asp Ala Asn Asn Leu Gln Ile Ala Val Ala 
             980                985                990
Arg Ile Lys Arg Gly Ile Asn Tyr Val Lys Gln Thr Leu Arg Glu Phe 
         995                1000                1005
Ile Leu Lys Ser Phe Ser Lys Lys Pro Lys Gly Ser Lys Asp Thr Lys 
     1010                1015                1020
Arg Thr Ala Asp Pro Asn Asn Lys Lys Glu Asn Tyr Ile Ser Asn Arg 
 1025                1030                1035                1040
Thr Leu Ala Glu Met Ser Lys Asp His Asn Phe Leu Lys Glu Lys Asp 
                 1045                1050                1055
Arg Ile Ser Gly Tyr Gly Ser Ser Leu Asp Lys Ser Phe Met Asp Glu 
             1060                1065                1070
Asn Asp Tyr Gln Ser Phe Ile His Asn Pro Ser Leu Thr Val Thr Val 
         1075                1080                1085
Pro Ile Ala Pro Gly Glu Ser Asp Leu Glu Ile Met Asn Thr Glu Glu 
     1090                1095                1100
Leu Ser Ser Asp Ser Asp Ser Asp Tyr Ser Lys Glu Lys Arg Asn Arg 
 1105                1110                1115                1120
Ser Ser Ser Ser Glu Cys Ser Thr Val Asp Asn Pro Leu Pro Gly Glu 
                 1125                1130                1135
Glu Glu Ala Glu Ala Glu Pro Val Asn Ala Asp Glu Pro Glu Ala Cys 
             1140                1145                1150
Phe Thr Asp Gly Cys Val Arg Arg Phe Pro Cys Cys Gln Val Asn Val 
         1155                1160                1165
Asp Ser Gly Lys Gly Lys Val Trp Trp Thr Ile Arg Lys Thr Cys Tyr 
     1170                1175                1180
Arg Ile Val Glu His Ser Trp Phe Glu Ser Phe Ile Val Leu Met Ile 
 1185                1190                1195                1200
Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu Lys 
                 1205                1210                1215
Lys Lys Thr Ile Lys Ile Ile Leu Glu Tyr Ala Asp Lys Ile Phe Thr 
             1220                1225                1230
Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Tyr 
         1235                1240                1245
Lys Thr Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile Val 
     1250                1255                1260
Asp Val Ser Leu Val Thr Leu Val Ala Asn Thr Leu Gly Tyr Ser Asp 
 1265                1270                1275                1280
Leu Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu 
                 1285                1290                1295
Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala Leu 
             1300                1305                1310
Ile Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile 
         1315                1320                1325
Phe Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys 
     1330                1335                1340
Phe Tyr Glu Cys Val Asn Thr Thr Asp Gly Ser Arg Phe Pro Thr Ser 
 1345                1350                1355                1360
Gln Val Ala Asn Arg Ser Glu Cys Phe Ala Leu Met Asn Val Ser Gly 
                 1365                1370                1375
Asn Val Arg Trp Lys Asn Leu Lys Val Asn Phe Asp Asn Val Gly Leu 
             1380                1385                1390
Gly Tyr Leu Ser Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp 
         1395                1400                1405
Ile Met Tyr Ala Ala Val Asp Ser Val Asn Val Asn Glu Gln Pro Lys 
     1410                1415                1420
Tyr Glu Tyr Ser Leu Tyr Met Tyr Ile Tyr Phe Val Ile Phe Ile Ile 
 1425                1430                1435                1440
Phe Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp 
                 1445                1450                1455
Asn Phe Asn Gln Gln Lys Lys Lys Leu Gly Gly Gln Asp Ile Phe Met 
             1460                1465                1470
Thr Glu Glu Gln Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser 
         1475                1480                1485
Lys Lys Pro Gln Lys Pro Ile Pro Arg Pro Gly Asn Lys Phe Gln Gly 
     1490                1495                1500
Cys Ile Phe Asp Leu Val Thr Asn Gln Ala Phe Asp Ile Thr Ile Met 
 1505                1510                1515                1520
Val Leu Ile Cys Leu Asn Met Val Thr Met Met Val Glu Lys Glu Gly 
                 1525                1530                1535
Gln Thr Glu Tyr Met Asp Tyr Val Leu His Trp Ile Asn Met Val Phe 
             1540                1545                1550
Ile Ile Leu Phe Thr Gly Glu Cys Val Leu Lys Leu Ile Ser Leu Arg 
         1555                1560                1565
His Tyr Tyr Phe Thr Val Gly Trp Asn Ile Phe Asp Phe Val Val Val 
     1570                1575                1580
Ile Leu Ser Ile Val Gly Met Phe Leu Ala Glu Met Ile Glu Lys Tyr 
 1585                1590                1595                1600
Phe Val Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly 
                 1605                1610                1615
Arg Ile Leu Arg Leu Ile Lys Gly Ala Lys Gly Ile Arg Thr Leu Leu 
             1620                1625                1630
Phe Ala Leu Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu 
         1635                1640                1645
Leu Phe Leu Val Met Phe Ile Tyr Ala Ile Phe Gly Met Ser Asn Phe 
     1650                1655                1660
Ala Tyr Val Lys Lys Glu Ala Gly Ile Asn Asp Met Phe Asn Phe Glu 
 1665                1670                1675                1680
Thr Phe Gly Asn Ser Met Ile Cys Leu Phe Gln Ile Thr Thr Ser Ala 
                 1685                1690                1695
Gly Trp Asp Gly Leu Leu Ala Pro Ile Leu Asn Ser Ala Pro Pro Asp 
             1700                1705                1710
Cys Asp Pro Lys Lys Val His Pro Gly Ser Ser Val Glu Gly Asp Cys 
         1715                1720                1725
Gly Asn Pro Ser Val Gly Ile Phe Tyr Phe Val Ser Tyr Ile Ile Ile 
     1730                1735                1740
Ser Phe Leu Val Val Val Asn Met Tyr Ile Ala Val Ile Leu Glu Asn 
 1745                1750                1755                1760
Phe Ser Val Ala Thr Glu Glu Ser Thr Glu Pro Leu Ser Glu Asp Asp 
                 1765                1770                1775
Phe Glu Met Phe Tyr Glu Val Trp Glu Lys Phe Asp Pro Asp Ala Thr 
             1780                1785                1790
Gln Phe Ile Glu Phe Cys Lys Leu Ser Asp Phe Ala Ala Ala Leu Asp 
         1795                1800                1805
Pro Pro Leu Leu Ile Ala Lys Pro Asn Lys Val Gln Leu Ile Ala Met 
     1810                1815                1820
Asp Leu Pro Met Val Ser Gly Asp Arg Ile His Cys Leu Asp Ile Leu 
 1825                1830                1835                1840
Phe Ala Phe Thr Lys Arg Val Leu Gly Glu Gly Gly Glu Met Asp Ser 
                 1845                1850                1855
Leu Arg Ser Gln Met Glu Glu Arg Phe Met Ser Ala Asn Pro Ser Lys 
             1860                1865                1870
Val Ser Tyr Glu Pro Ile Thr Thr Thr Leu Lys Arg Lys Gln Glu Glu 
         1875                1880                1885
Val Ser Ala Thr Ile Ile Gln Arg Ala Tyr Arg Arg Tyr Arg Leu Arg 
     1890                1895                1900
Gln His Val Lys Asn Ile Ser Ser Ile Tyr Ile Lys Asp Gly Asp Arg 
 1905                1910                1915                1920
Asp Asp Asp Leu Pro Asn Lys Glu Asp Thr Val Phe Asp Asn Val Asn 
                 1925                1930                1935
Glu Asn Ser Ser Pro Glu Lys Thr Asp Val Thr Ala Ser Thr Ile Ser 
             1940                1945                1950
Pro Pro Ser Tyr Asp Ser Val Thr Lys Pro Asp Gln Glu Lys Tyr Glu 
         1955                1960                1965
Thr Asp Lys Thr Glu Lys Glu Asp Lys Glu Lys Asp Glu Ser Arg Lys 
     1970                1975                1980



<210> 8962
<211> 7831
<212> DNA
<213> Homo sapiens
<308> XM_008249
<400> 8962

ccagcaccc  ggggctgcg  actgcagct  cccaggcca  ccaccaccc  tctggtctc  60
gagcccagg  tgcgaggat  gccagacca  ctctgtgca  cctggtgcc  ctgggccct  120
agtgcttgc  ccccttcac  cgggagtca  tggcagcca  agaacagcg  gcggtggag  180
aggaggccc  gctgcagcg  aataagcag  tggagattg  ggagcccga  cggaagcca  240
gaagtgact  ggaggctgg  aagaaccta  ccatgatct  cggagaccc  ccgccggag  300
tcatcggca  ccccctgga  gacctggat  cctactaca  caataagaa  accttcatc  360
tactcaaca  gggcaaggc  atcttccgc  tctccgcca  acctgctct  tacctgctg  420
gccccttca  cgtagtcag  cgcggggcc  tcaaggtgc  catccatgc  ctgttcagc  480
tgttcatca  gatcaccat  ttgaccaac  gcgtattca  gaccatgag  gacccgcct  540
cctggtcca  gaatgtgga  tacaccttc  cagggatct  cacctttga  tccctcatc  600
agatactgg  ccgaggctt  tgtgtcgac  acttcacat  cctccggga  ccctggaac  660
ggctggact  cagtgtcat  atgatggcg  acctgacag  gtttgtgga  ttgggcaac  720
tctcagccc  gaggacctt  cgggtgctg  gggccctca  aaccatcac  gtcatccca  780
ggctgaaga  gatcgtggg  gccctgatc  agtcggtga  aaagctgtc  gatgtgatg  840
tcctcactg  cttctgcct  agcgtcttt  cgctggtag  actgcagct  ttcatggga  900
acctgaggc  gaagtgtgt  cgctggccc  cgccgttca  cgacaccaa  accacgtgg  960
acagcaatg  cacgtggta  ggcaatgac  catggtatg  caatgagat  tggtacggc  1020
atgactcat  gtatgccaa  gacacgtgg  acagccatg  aagctgggc  accaacgat  1080
cctttgatt  ggacgccta  atcagtgat  aagggaact  ctacttcct  gagggctcc  1140
acgatgccc  gctctgtgg  aacagcagt  atgctgggc  ctgccctga  ggttatgag  1200
gcatcaaga  cgggcggaa  cccaactat  gctacacca  ctatgacac  ttcagctgg  1260
ccttcttgg  tctcttccg  ctcatgaca  aggactatt  ggagaacct  ttccagctg  1320
cccttcgag  agctggcaa  acctacatg  tcttcttcg  ggtcatcat  ttcctgggc  1380
ctttctacc  catcaatct  atcctggcc  tggtggcca  ggcatatgc  gagcagaat  1440
aggccaccc  ggccgagga  aaggagaaa  aggaggagt  tcagcagat  cttgagaag  1500
tcaaaaagc  ccaggagga  ctggagaag  ccaaggccg  ccaagctct  gaaggtggg  1560
aggcagatg  ggacccagc  catggcaaa  actgcaatg  cagcctgga  acatcgcaa  1620
gggagaagg  agccccgag  cagagcggc  gcggagaca  cggcatctc  gacgccatg  1680
aagaactgg  agaggccca  caaaagtgc  caccatggt  gtacaagtg  gcccacaaa  1740
tgctcatat  gaactgctg  gccccgtgg  tgaagttca  gaacatcat  cacctgatc  1800
tcatggacc  gttcgtgga  ctgggcatc  ccatctgca  cgtgctcaa  accctcttc  1860
tggccatgg  acattaccc  atgacggag  actttgaca  cgtgctcac  gtgggcaac  1920
tggtcttca  aggcatctt  acagcagag  tggttctga  gctgattgc  atggacccc  1980
acgagtatt  ccagcaggg  tggaatatc  tcgacagca  catcgtcac  ctcagcctg  2040
tagagctag  cctggccaa  gtacaggga  tgtctgtgc  acgctcctt  cgtctgctg  2100
gggtcttca  gctggccaa  tcgtggcca  cgctgaaca  gctcatcaa  atcattggc  2160
attcagtgg  ggcgctggg  aacctgacg  tggtgctgg  tatcatcgt  ttcatcttc  2220
ccgtggtgg  catgcagct  tttggcaag  gctacaagg  gtgcgtgtg  aagattgcc  2280
tggactgca  cctgccgcg  tggcacatg  atgatttct  ccactcctt  ctcatcgtc  2340
tccgcatcc  gtgcgggga  tggatcgag  ccatgtggg  ctgcatgga  gtggccggc  2400
aagccatgt  cctcaccgt  ttcctcatg  tcatggtca  cggcaatct  gtggtcctg  2460
acctgttcc  ggctctgct  ctgagctcc  tcagcgccg  cagtctggc  gcctcggat  2520
aggatggcg  gatgaacaa  ctgcagatt  ccatcgggc  catcaagtt  ggcatcggc  2580
ttgccaagg  cttcctcct  gggctgctg  atggcaaga  cctgagccc  aaggacatc  2640
tgctcagcc  cggggaggc  gacggggcc  gggaggctg  agaggcggg  gagactgcc  2700
ccgaggatg  gaagaagga  ccgcccgag  aggacctga  gaaggacaa  cacatcctg  2760
accacatgg  cctggctga  ggcccccca  ccagcctcg  gctggacca  cttaacttc  2820
tcaacaacc  ctacctgac  atacaggtg  ccatcgcct  cgaggagtc  gacctggag  2880
tgcccaccg  ggaggaaac  gacactttc  cagagcctg  ggatagcaa  aagccgccg  2940
agcctctct  tgatgggaa  tcgtccgtc  gcagcacag  tgactacaa  ccccccgag  3000
aggaccctg  ggagcaggc  gaggagaac  ccgaggggg  gcagcctga  gagtgcttc  3060
ctgaggcct  cgtgcagcg  tggccctgc  tctacgtgg  catctccca  ggccgtggg  3120
agaagtggt  gactctgcg  agggcctgc  tcaagattg  cgagcacaa  tggttcgag  3180
ccttcattg  cttcatgat  ctgctcagc  gtggggctc  ggccttcga  gacatctac  3240
ttgagcagc  gcgagtcat  cgcaccatc  tagaatatg  cgacaaggt  ttcacctac  3300
tcttcatca  ggagatgct  ctcaaatgg  tggcctacg  ctttaaggt  tacttcacc  3360
acgcctggt  ctggctcga  ttcctcatc  tggatgtct  catcatcag  ttggtggcc  3420
actggctgg  ctactcgga  ctgggaccc  tcaaatccc  gcggacact  cgggccctg  3480
gtcccctga  ggcactgtc  cgattcgag  gcatgaggg  ggtggtgaa  gccctccta  3540
gcgccatcc  ctccatcat  aatgtgctg  ttgtctgcc  catcttctg  ctgatcttc  3600
gcatcatgg  tgtcaacct  tttgccggc  agttctact  ctgcatcaa  accaccacc  3660
ctgagaggt  cgacatctc  gaggtcaac  acaagtctg  gtgcgagag  ctcatgcac  3720
caggccagg  ccgctggct  aatgtcaag  tcaactacg  caacgtggg  ctgggctac  3780
tctccctcc  gcaggtggc  accttcaag  gttggatgg  catcatgta  gcagccgtg  3840
actcccggg  gaaggagga  cagccgcag  acgaggtga  cctctacat  tacctctac  3900
ttgtcatct  catcatctt  ggctccttc  tcaccctca  cctcttcat  ggcgtcatc  3960
ttgacaact  caaccagca  aagaagaag  tagggggga  agacatctt  atgacggag  4020
aacagaaga  atactataa  gccatgaag  agcttggct  caagaagcc  cagaagcca  4080
ttccccggc  ccagaacaa  atccagggc  tggtgtatg  cctcgtgac  aagcaggcc  4140
tcgacatca  catcatgat  ctcatctgc  tcaacatgg  caccatgat  gtggagaca  4200
acaaccaga  ccagctcaa  gtggacatc  tgtacaaca  caacatgat  ttcatcatc  4260
tcttcacag  ggagtgcgt  ctcaagatg  tcgccctgc  ccagtacta  ttcaccgtt  4320
gctggaaca  ctttgactt  gtggtcgtc  tcctgtcca  tgtgggcct  gccctctct  4380
acctgatcc  gaagtactt  gtgtcaccc  cgctgttcc  tgtgatccg  ctggcgcgg  4440
ttgggcgtg  cctgcggct  atccgcggg  ccaagggca  ccggacgct  ctgttcgcc  4500
tcatgatgt  gctgcctgc  ctcttcaac  tcggcctcc  cctcttcct  gtcatgttc  4560
tctactcca  cttcggcat  tccaacttt  cctacgtca  gaaggagtc  ggcatcgat  4620
atatgttca  cttcgagac  ttcggcaac  gcatcatct  cctgttcga  atcaccacg  4680
cggccggct  ggacgggct  ctcaacccc  tcctcaaca  cgggccccc  gactgtgac  4740
ccaacctgg  gaacccggg  accagtgtc  agggtgact  cggcaaccc  tccatcggc  4800
tctgcttct  ctgcagcta  atcatcatc  ccttcctca  cgtggtcaa  atgtacatc  4860
ccatcatcc  ggagaactt  aatgtggcc  cagaggaga  cagcgagcc  cttggtgaa  4920
atgactttg  gatgttcta  gagacatgg  agaagttcg  ccccgacgc  acccagttc  4980
tcgcctaca  ccgcctctc  gacttcgtg  acaccctgc  ggaaccgct  aggattgcc  5040
agcccaaca  gatcaagct  atcacactg  acttgccca  ggtgccagg  gacaagatc  5100
actgcctgg  catcctctt  gccctgacc  aagaggtcc  gggtgactc  ggggaaatg  5160
acgccctca  gcagaccat  gaggagaag  tcatggcag  caacccctc  aaggtgtcc  5220
acgagccca  caccaccac  ctcaagagg  agcacgagg  ggtgtgcgc  atcaagatc  5280
agagggcct  ccgccggca  ctgctacag  gctccatga  gcaggcatc  tacatgtac  5340
gccacagcc  cgacggcag  ggggatgac  cccctgaga  ggaggggct  cttgccaac  5400
ccatgagca  gatgtatgg  cacgagaat  ggaacagca  ctcgccaag  ccggaggag  5460
agggcgagg  aggggacgc  ggacccact  tggggctga  gcccatcag  ccctcagac  5520
ctgcctggc  tcccgcccc  cccccaggg  agactgtgc  cccaggtgt  aaggagtct  5580
ttgtctagc  ggcagcatc  gggtggccc  ctgagtctc  gcatagtcc  cagagctcc  5640
ccgtggtgc  tgcacacag  gtgagggag  agggctttg  atctgggac  gtgcctggc  5700
ccctgatgg  ggacaggat  tggccacac  ggggctgac  cccaggccc  agcgcctgc  5760
ttcccagac  atgggaaat  ggaattgcg  tcaggggct  catgctggg  ctgaggccc  5820
tgcctccaa  atttaacct  caagttgct  tgacctcct  tgggccctg  cgcccctcc  5880
tttggcctg  gggaggtca  aacattcga  tctctgccc  tcacttgag  aggagctgg  5940
ctgcggtgg  gggatcagt  gccccccat  accagagtc  taagggtca  tggcctctc  6000
ccaggaagt  gctcagacc  ctcagcccc  gcccagaca  agatgtctt  acctcaggg  6060
gtgcagaca  ctaacccca  ggcactgcc  gcccacccc  tttgactct  gggtgcagc  6120
tcacccacc  ggccagctc  ggaattccc  agaaaaggg  aatgtgact  gttcagaaa  6180
agctcctca  agcctcaaa  cctgattgg  cactggatc  tgctgcttt  ggctgggat  6240
gtgactcct  aaacctctt  ctaggccac  tccaggtcc  tagctcccc  ggctggccc  6300
taggggaag  gcagaagga  ggatgccac  tgggaatga  ttgtccttt  ctaggaagc  6360
cgggggagt  agacaggct  ggtcctgcc  gctggatcg  tgcacatgg  ctgagcatc  6420
agacctgag  gggagtcag  gacctgctg  tcagtaaga  gattctcgc  ccttccctc  6480
ctccctgcc  cactcctcc  tgagcacca  cagggctcc  ggagcctca  ccagcctca  6540
agatctccc  tctcatctc  ccacgcccg  ctctttctc  cctttccca  ctctctccc  6600
aaagtgatc  taagaatgt  cagttgagc  caggttaga  atttcgacc  tggggcgtg  6660
agcagggaa  gcccaactg  ttcaggctc  accttccaa  ttcctgtgg  ctgaagaag  6720
acttctgct  catcgctgt  ctgggcatg  cagggccag  cctctgctg  ctcctggag  6780
gcagaggct  tgcccagag  aggaggggt  agagacctg  tcaggcgtc  ctggattta  6840
tcacttgtg  gtgtacctg  ggctgtgtg  ctgcttgta  gcatttata  gcctgtgtg  6900
atagctgtg  gtgtgttca  gtgcgtgac  gtatgtgtg  gtgtgaacc  ctgtgtact  6960
gagcctgca  tatgcacgt  tctgggtat  tttgtatat  tgtgtatat  tgtgtgccc  7020
ggactgttt  aaggtccac  gagtacggc  ggtgtgtca  actgtgcag  cctgtccct  7080
ggagtgttc  cgtgcctgg  agagtggac  tgtgctgtg  gtgtgtgga  gcgtgtgaa  7140
gcatgtggt  aggtgtgta  tcagggcat  ctgttggcc  aagtgcctc  tctttttct  7200
cttgtttct  atgaaaagt  tgattaaaa  tcaggaagc  gcaaaacct  caaaacaag  7260
catgtatgt  tgcttgagt  tgtgaacac  tgtgtgtgt  tgtgcacat  tacatgcca  7320
gcctatggg  cagagttgt  tttattgtc  accatgctc  ctcacctgc  cccagtcct  7380
cctgaacag  cctctctct  actcccctc  cctcccctt  ctgtttctc  ttgtcacac  7440
catggcctc  gccctgctc  ctgcctcct  cctatgtct  ctctatgga  ggaggcctc  7500
actccttcc  tctcttcct  cagaagttt  gtctaatgg  ggcagtctc  ccttcctgg  7560
acattgccc  tctgccttg  cctcctggg  cctgggctg  cacagcccc  ggagcctca  7620
aaatctgtt  gattggata  tctcctcgg  ctgtgtgca  gttgcagag  aagagtaga  7680
gagccgggt  cggcctctc  ctgcctgtg  cccctcccc  gcagacgga  gcccattcc  7740
gcctggtcc  gtggggaac  ggtcccacg  caggccagc  ggcgggctc  tttgtacag  7800
tcttacaat  aaccctcct  ggtgcctct  g  7831



<210> 8963
<211> 1836
<212> PRT
<213> Homo sapiens
<308> XP_008249
<400> 8963

Met Ala Arg Pro Ser Leu Cys Thr Leu Val Pro Leu Gly Pro Glu Cys 
  1               5                  10                  15
Leu Arg Pro Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ala 
             20                  25                  30
Val Glu Glu Glu Ala Arg Leu Gln Arg Asn Lys Gln Met Glu Ile Glu 
         35                  40                  45
Glu Pro Glu Arg Lys Pro Arg Ser Asp Leu Glu Ala Gly Lys Asn Leu 
     50                  55                  60
Pro Met Ile Tyr Gly Asp Pro Pro Pro Glu Val Ile Gly Ile Pro Leu 
 65                  70                  75                  80
Glu Asp Leu Asp Pro Tyr Tyr Ser Asn Lys Lys Thr Phe Ile Val Leu 
                 85                  90                  95
Asn Lys Gly Lys Ala Ile Phe Arg Phe Ser Ala Thr Pro Ala Leu Tyr 
             100                105                110
Leu Leu Ser Pro Phe Ser Val Val Arg Arg Gly Ala Ile Lys Val Leu 
         115                120                125
Ile His Ala Leu Phe Ser Met Phe Ile Met Ile Thr Ile Leu Thr Asn 
     130                135                140
Cys Val Phe Met Thr Met Ser Asp Pro Pro Pro Trp Ser Lys Asn Val 
 145                150                155                160
Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile 
                 165                170                175
Leu Ala Arg Gly Phe Cys Val Asp Asp Phe Thr Phe Leu Arg Asp Pro 
             180                185                190
Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Leu Thr Glu 
         195                200                205
Phe Val Asp Leu Gly Asn Ile Ser Ala Leu Arg Thr Phe Arg Val Leu 
     210                215                220
Arg Ala Leu Lys Thr Ile Thr Val Ile Pro Gly Leu Lys Thr Ile Val 
 225                230                235                240
Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu 
                 245                250                255
Thr Val Phe Cys Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe 
             260                265                270
Met Gly Asn Leu Arg Gln Lys Cys Val Arg Trp Pro Pro Pro Phe Asn 
         275                280                285
Asp Thr Asn Thr Thr Trp Tyr Ser Asn Asp Thr Trp Tyr Gly Asn Asp 
     290                295                300
Thr Trp Tyr Gly Asn Glu Met Trp Tyr Gly Asn Asp Ser Trp Tyr Ala 
 305                310                315                320
Asn Asp Thr Trp Asn Ser His Ala Ser Trp Ala Thr Asn Asp Thr Phe 
                 325                330                335
Asp Trp Asp Ala Tyr Ile Ser Asp Glu Gly Asn Phe Tyr Phe Leu Glu 
             340                345                350
Gly Ser Asn Asp Ala Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly His 
         355                360                365
Cys Pro Glu Gly Tyr Glu Cys Ile Lys Thr Gly Arg Asn Pro Asn Tyr 
     370                375                380
Gly Tyr Thr Ser Tyr Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe 
 385                390                395                400
Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Phe Gln Leu Thr Leu 
                 405                410                415
Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Ile Ile Phe 
             420                425                430
Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val Ala Met 
         435                440                445
Ala Tyr Ala Glu Gln Asn Glu Ala Thr Leu Ala Glu Asp Lys Glu Lys 
     450                455                460
Glu Glu Glu Phe Gln Gln Met Leu Glu Lys Phe Lys Lys His Gln Glu 
 465                470                475                480
Glu Leu Glu Lys Ala Lys Ala Ala Gln Ala Leu Glu Gly Gly Glu Ala 
                 485                490                495
Asp Gly Asp Pro Ala His Gly Lys Asp Cys Asn Gly Ser Leu Asp Thr 
             500                505                510
Ser Gln Gly Glu Lys Gly Ala Pro Arg Gln Ser Gly Ser Gly Asp Ser 
         515                520                525
Gly Ile Ser Asp Ala Met Glu Glu Leu Glu Glu Ala His Gln Lys Cys 
     530                535                540
Pro Pro Trp Trp Tyr Lys Cys Ala His Lys Val Leu Ile Trp Asn Cys 
 545                550                555                560
Cys Ala Pro Trp Leu Lys Phe Lys Asn Ile Ile His Leu Ile Val Met 
                 565                570                575
Asp Pro Phe Val Asp Leu Gly Ile Thr Ile Cys Ile Val Leu Asn Thr 
             580                585                590
Leu Phe Met Ala Met Glu His Tyr Pro Met Thr Glu His Phe Asp Asn 
         595                600                605
Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu 
     610                615                620
Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Gln 
 625                630                635                640
Gly Trp Asn Ile Phe Asp Ser Ile Ile Val Thr Leu Ser Leu Val Glu 
                 645                650                655
Leu Gly Leu Ala Asn Val Gln Gly Leu Ser Val Leu Arg Ser Phe Arg 
             660                665                670
Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met 
         675                680                685
Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr 
     690                695                700
Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln 
 705                710                715                720
Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Ala Leu Asp 
                 725                730                735
Cys Asn Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu 
             740                745                750
Ile Val Phe Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp 
         755                760                765
Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Leu Met 
     770                775                780
Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu 
 785                790                795                800
Leu Leu Ser Ser Phe Ser Ala Asp Ser Leu Ala Ala Ser Asp Glu Asp 
                 805                810                815
Gly Glu Met Asn Asn Leu Gln Ile Ala Ile Gly Arg Ile Lys Leu Gly 
             820                825                830
Ile Gly Phe Ala Lys Ala Phe Leu Leu Gly Leu Leu His Gly Lys Ile 
         835                840                845
Leu Ser Pro Lys Asp Ile Met Leu Ser Leu Gly Glu Ala Asp Gly Ala 
     850                855                860
Gly Glu Ala Gly Glu Ala Gly Glu Thr Ala Pro Glu Asp Glu Lys Lys 
 865                870                875                880
Glu Pro Pro Glu Glu Asp Leu Lys Lys Asp Asn His Ile Leu Asn His 
                 885                890                895
Met Gly Leu Ala Asp Gly Pro Pro Ser Ser Leu Glu Leu Asp His Leu 
             900                905                910
Asn Phe Ile Asn Asn Pro Tyr Leu Thr Ile Gln Val Pro Ile Ala Ser 
         915                920                925
Glu Glu Ser Asp Leu Glu Met Pro Thr Glu Glu Glu Thr Asp Thr Phe 
     930                935                940
Ser Glu Pro Glu Asp Ser Lys Lys Pro Pro Gln Pro Leu Tyr Asp Gly 
 945                950                955                960
Asn Ser Ser Val Cys Ser Thr Ala Asp Tyr Lys Pro Pro Glu Glu Asp 
                 965                970                975
Pro Glu Glu Gln Ala Glu Glu Asn Pro Glu Gly Glu Gln Pro Glu Glu 
             980                985                990
Cys Phe Thr Glu Ala Cys Val Gln Arg Trp Pro Cys Leu Tyr Val Asp 
         995                1000                1005
Ile Ser Gln Gly Arg Gly Lys Lys Trp Trp Thr Leu Arg Arg Ala Cys 
     1010                1015                1020
Phe Lys Ile Val Glu His Asn Trp Phe Glu Thr Phe Ile Val Phe Met 
 1025                1030                1035                1040
Ile Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu 
                 1045                1050                1055
Gln Arg Arg Val Ile Arg Thr Ile Leu Glu Tyr Ala Asp Lys Val Phe 
             1060                1065                1070
Thr Tyr Ile Phe Ile Met Glu Met Leu Leu Lys Trp Val Ala Tyr Gly 
         1075                1080                1085
Phe Lys Val Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile 
     1090                1095                1100
Val Asp Val Ser Ile Ile Ser Leu Val Ala Asn Trp Leu Gly Tyr Ser 
 1105                1110                1115                1120
Glu Leu Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro 
                 1125                1130                1135
Leu Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala 
             1140                1145                1150
Leu Leu Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu 
         1155                1160                1165
Ile Phe Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly 
     1170                1175                1180
Lys Phe Tyr Tyr Cys Ile Asn Thr Thr Thr Ser Glu Arg Phe Asp Ile 
 1185                1190                1195                1200
Ser Glu Val Asn Asn Lys Ser Glu Cys Glu Ser Leu Met His Thr Gly 
                 1205                1210                1215
Gln Val Arg Trp Leu Asn Val Lys Val Asn Tyr Asp Asn Val Gly Leu 
             1220                1225                1230
Gly Tyr Leu Ser Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp 
         1235                1240                1245
Ile Met Tyr Ala Ala Val Asp Ser Arg Glu Lys Glu Glu Gln Pro Gln 
     1250                1255                1260
Tyr Glu Val Asn Leu Tyr Met Tyr Leu Tyr Phe Val Ile Phe Ile Ile 
 1265                1270                1275                1280
Phe Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp 
                 1285                1290                1295
Asn Phe Asn Gln Gln Lys Lys Lys Leu Gly Gly Lys Asp Ile Phe Met 
             1300                1305                1310
Thr Glu Glu Gln Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser 
         1315                1320                1325
Lys Lys Pro Gln Lys Pro Ile Pro Arg Pro Gln Asn Lys Ile Gln Gly 
     1330                1335                1340
Met Val Tyr Asp Leu Val Thr Lys Gln Ala Phe Asp Ile Thr Ile Met 
 1345                1350                1355                1360
Ile Leu Ile Cys Leu Asn Met Val Thr Met Met Val Glu Thr Asp Asn 
                 1365                1370                1375
Gln Ser Gln Leu Lys Val Asp Ile Leu Tyr Asn Ile Asn Met Ile Phe 
             1380                1385                1390
Ile Ile Ile Phe Thr Gly Glu Cys Val Leu Lys Met Leu Ala Leu Arg 
         1395                1400                1405
Gln Tyr Tyr Phe Thr Val Gly Trp Asn Ile Phe Asp Phe Val Val Val 
     1410                1415                1420
Ile Leu Ser Ile Val Gly Leu Ala Leu Ser Asp Leu Ile Gln Lys Tyr 
 1425                1430                1435                1440
Phe Val Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly 
                 1445                1450                1455
Arg Val Leu Arg Leu Ile Arg Gly Ala Lys Gly Ile Arg Thr Leu Leu 
             1460                1465                1470
Phe Ala Leu Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu 
         1475                1480                1485
Leu Phe Leu Val Met Phe Ile Tyr Ser Ile Phe Gly Met Ser Asn Phe 
     1490                1495                1500
Ala Tyr Val Lys Lys Glu Ser Gly Ile Asp Asp Met Phe Asn Phe Glu 
 1505                1510                1515                1520
Thr Phe Gly Asn Ser Ile Ile Cys Leu Phe Glu Ile Thr Thr Ser Ala 
                 1525                1530                1535
Gly Trp Asp Gly Leu Leu Asn Pro Ile Leu Asn Ser Gly Pro Pro Asp 
             1540                1545                1550
Cys Asp Pro Asn Leu Glu Asn Pro Gly Thr Ser Val Lys Gly Asp Cys 
         1555                1560                1565
Gly Asn Pro Ser Ile Gly Ile Cys Phe Phe Cys Ser Tyr Ile Ile Ile 
     1570                1575                1580
Ser Phe Leu Ile Val Val Asn Met Tyr Ile Ala Ile Ile Leu Glu Asn 
 1585                1590                1595                1600
Phe Asn Val Ala Thr Glu Glu Ser Ser Glu Pro Leu Gly Glu Asp Asp 
                 1605                1610                1615
Phe Glu Met Phe Tyr Glu Thr Trp Glu Lys Phe Asp Pro Asp Ala Thr 
             1620                1625                1630
Gln Phe Ile Ala Tyr Ser Arg Leu Ser Asp Phe Val Asp Thr Leu Gln 
         1635                1640                1645
Glu Pro Leu Arg Ile Ala Lys Pro Asn Lys Ile Lys Leu Ile Thr Leu 
     1650                1655                1660
Asp Leu Pro Met Val Pro Gly Asp Lys Ile His Cys Leu Asp Ile Leu 
 1665                1670                1675                1680
Phe Ala Leu Thr Lys Glu Val Leu Gly Asp Ser Gly Glu Met Asp Ala 
                 1685                1690                1695
Leu Lys Gln Thr Met Glu Glu Lys Phe Met Ala Ala Asn Pro Ser Lys 
             1700                1705                1710
Val Ser Tyr Glu Pro Ile Thr Thr Thr Leu Lys Arg Lys His Glu Glu 
         1715                1720                1725
Val Cys Ala Ile Lys Ile Gln Arg Ala Tyr Arg Arg His Leu Leu Gln 
     1730                1735                1740
Arg Ser Met Lys Gln Ala Ser Tyr Met Tyr Arg His Ser His Asp Gly 
 1745                1750                1755                1760
Ser Gly Asp Asp Ala Pro Glu Lys Glu Gly Leu Leu Ala Asn Thr Met 
                 1765                1770                1775
Ser Lys Met Tyr Gly His Glu Asn Gly Asn Ser Ser Ser Pro Ser Pro 
             1780                1785                1790
Glu Glu Lys Gly Glu Ala Gly Asp Ala Gly Pro Thr Met Gly Leu Met 
         1795                1800                1805
Pro Ile Ser Pro Ser Asp Thr Ala Trp Pro Pro Ala Pro Pro Pro Gly 
     1810                1815                1820
Gln Thr Val Arg Pro Gly Val Lys Glu Ser Leu Val 
 1825                1830                1835



<210> 8964
<211> 3498
<212> DNA
<213> Rattus norvegicus
<308> U81035
<400> 8964

attgagatt  cgatggatc  gacccaacc  ccaacgatc  ccaagcagt  ggtgaagga  60
cacatcgtg  acccccgag  taacatcct  attgaatgt  aagctaaag  gaaccccgc  120
cccagtttc  actggactc  caacagcag  ttcttcaac  ttgccaagg  cccacgggt  180
tccatgagg  ggaggtctg  gaccttggt  atcgacttc  gcagtggtg  gcggcctga  240
gagtacgaa  gggagtacc  gtgctttgc  cggaacaaa  tcggcacag  tcttagcaa  300
ccgatccgc  tgcaggtgt  caaatctcc  ctgtggccc  aggaaaacc  agaccccgt  360
gtggttcaa  agggtgccc  cttaaccct  cagtgcaac  ccccacctg  cctcccatc  420
cccgtcatc  tctggatga  cacgtccat  gagcccatc  cccaggaca  gcgtgtctc  480
cagggtcac  acggggacc  gtacttctc  aacgtcatg  tgcaggaca  gcagaccga  540
tacagctgc  atgcacgct  ccacttcac  cacaccatt  agcagaaga  tcccttcac  600
ctcaaagtc  tcaccaaca  cccctataa  gactcgtct  taagaaacc  ccctgacat  660
tatagtgcc  gaggagttg  ggaaagaac  cctagcttc  tgtatcccc  gggcacgtc  720
agcagtcag  tggtactgc  cggcatgga  ctgctgctg  agtgcattg  ctctggggt  780
ccaacacca  atattgcat  gtacaagaa  ggtggggac  tcccatctg  caaggccaa  840
ttcgagaat  ttaacaagg  tctgcgcat  accaatgtc  ctgaagagg  ctctgggga  900
tatttctgc  tggcctcca  caagatggg  agcatccgg  acacgatct  ggtgagagt  960
aaggctgcc  catactggc  ggatgagcc  aagaacttg  tcctggctc  tggtgaaga  1020
gggaggctg  tgtgtcgag  caatgggaa  ccgaagccg  ccgtccagt  gctggtgaa  1080
ggagaccct  tgcaatcgg  accacccaa  cccaaccgt  aggtggccg  agacactat  1140
atcttccgg  acactcaga  cagcagcag  gcagtgtac  agtgtaaca  atccaacga  1200
catggctac  tgctggcca  tgccttcgt  agcgtatta  atgtacccc  tcggatgct  1260
tctccccgg  accagctca  cagggtgat  ctttacaac  ggacgcgac  ggactgtcc  1320
ttctttggg  ctcccattc  aacactccg  tggtttaag  atgggcaag  aagcaacct  1380
gatggtggt  actaccacg  ctaccaaaa  ggcagcctg  aaatcaaga  gattcgcaa  1440
gaggaccaa  gcatctaca  ctgtgtggc  accaacatc  tgggaaaag  tgaaaatca  1500
gtccgcctg  aggtcaaag  ccccaccag  atctacagg  tgcctgaag  ccaggtggc  1560
aagaggggc  ccacagtgc  gctggagtg  cgtgtgaag  atgacccct  cttgaaact  1620
acagtctcc  ggctgaagg  tgacgagcc  ctctacatt  gaaacagga  gaaaaagga  1680
gatgactcc  tgaccatct  cggagtggc  gagcgggac  aaggcagtt  cacgtgcat  1740
gccagcacc  agctggacc  ggacctggc  aaggcctac  tcactgttc  agctgatca  1800
gccactccg  ctaaccgtt  ggctgccct  cccaaaggg  ggccagacc  acccaggga  1860
ctggagctc  ctgacctgg  ggaaaggag  gtgaggctg  cctggatcc  gggggatga  1920
aacaacagt  ccatcacag  ctacgttgt  cagtttgaa  aggaccagt  ccagccagg  1980
gtcttgcat  accactcca  gttcccagg  agtgtcaac  cagccgtcc  ccatctgtc  2040
ccgtatgtc  actatgact  ccgagtcat  gctgtcaac  aggttggga  cagccaccc  2100
agccttcca  ccgagcggt  ccgaacaag  ggggcaccc  ctgaatcca  ccccagtga  2160
gtgaagggc  aagggacac  aaaaaacaa  atggagatc  catggacgc  tatgaatgc  2220
acctccgcc  ttggcccca  cctgcgcta  tacattgtc  agtggcgac  gagagaaac  2280
cgagagact  ggaacaatg  caccgtgtg  ggctctcgc  atgtggtgg  gcagacccc  2340
gtctacgta  cctatgaga  ccgagtcca  gctgaaaat  actttggga  aggcccgga  2400
cctgaaacc  tcattgggt  ctcggggga  gattatccc  gggctgcac  cactgaagt  2460
aaaatccga  tcctgaaca  cacagccat  agccttcag  ggaaccgcg  ctaccctga  2520
acggtccag  gccagctca  agagtatcg  gcttactac  ggagggaaa  cagtttgct  2580
aagaacctg  gggtgtctc  gaagagaca  caggccagc  tccctggcg  ccgcccccg  2640
ggcgtggtg  gtcgcctgt  cccctacag  aactacaag  tggagatgg  tgtggtcaa  2700
gggagaggt  atgggcctc  aagtgaaac  aaggaattc  ccaccccgg  aggagtacc  2760
agtgccccc  ggcgtttca  agtccgaca  cccaacctg  agaccatca  cctggaatg  2820
gatcaccca  agcacccca  cgggatcct  attggatac  cgctcagat  cgtgccctt  2880
aatggaacc  aactgggaa  gcagatggt  gaaaacttc  ctcccaatc  gaccaagtt  2940
tcggtgcag  gagcagacc  cgtgtcccg  taccgcttc  ccctcagtg  caggacgca  3000
gtgggctct  gagaagcag  cacggagga  tccccaaca  ctccaaatg  agctactcc  3060
actgcagct  acaccaaca  ccagactga  atcgccacc  agggctggt  catcgggct  3120
atgtgtgcc  ttgcccttc  ggtgctgat  ctgctgatc  tctgcttca  caagaggag  3180
cgtggcggc  agtacccag  gcgagaaaa  aaggatgtc  ccttgggcc  tgaagaccc  3240
aaagaagaa  atggttcat  tgactacag  gacgaggac  acaagcccc  gcagggcag  3300
cagacatct  tggacggca  catcaagca  caggagagt  acgacagcc  agtggacta  3360
ggcgagggt  gcgagggcc  gttcaacga  gatggctcc  ttattggcc  gtacactgt  3420
agaaaggac  aggaggaga  cgagggcaa  gagagctca  aggccacat  tccagtcaa  3480
gccatctat  ccctggcc  3498



<210> 8965
<211> 1217
<212> PRT
<213> Rattus norvegicus
<308> AAB47753
<400> 8965

Ile Glu Ile Pro Met Asp Pro Ser Ile Gln Asn Glu Leu Thr Gln Pro 
  1               5                  10                  15
Pro Thr Ile Thr Lys Gln Ser Val Lys Asp His Ile Val Asp Pro Arg 
             20                  25                  30
Asp Asn Ile Leu Ile Glu Cys Glu Ala Lys Gly Asn Pro Ala Pro Ser 
         35                  40                  45
Phe His Trp Thr Arg Asn Ser Arg Phe Phe Asn Ile Ala Lys Asp Pro 
     50                  55                  60
Arg Val Ser Met Arg Arg Arg Ser Gly Thr Leu Val Ile Asp Phe Arg 
 65                  70                  75                  80
Ser Gly Gly Arg Pro Glu Glu Tyr Glu Gly Glu Tyr Gln Cys Phe Ala 
                 85                  90                  95
Arg Asn Lys Phe Gly Thr Ala Leu Ser Asn Arg Ile Arg Leu Gln Val 
             100                105                110
Ser Lys Ser Pro Leu Trp Pro Lys Glu Asn Leu Asp Pro Val Val Val 
         115                120                125
Gln Glu Gly Ala Pro Leu Thr Leu Gln Cys Asn Pro Pro Pro Gly Leu 
     130                135                140
Pro Ser Pro Val Ile Phe Trp Met Ser Ser Ser Met Glu Pro Ile Thr 
 145                150                155                160
Gln Asp Lys Arg Val Ser Gln Gly His Asn Gly Asp Leu Tyr Phe Ser 
                 165                170                175
Asn Val Met Leu Gln Asp Met Gln Thr Asp Tyr Ser Cys Asn Ala Arg 
             180                185                190
Phe His Phe Thr His Thr Ile Gln Gln Lys Asn Pro Phe Thr Leu Lys 
         195                200                205
Val Leu Thr Thr Arg Gly Val Ala Glu Arg Thr Pro Ser Phe Met Tyr 
     210                215                220
Pro Gln Gly Thr Ser Ser Ser Gln Met Val Leu Arg Gly Met Asp Leu 
 225                230                235                240
Leu Leu Glu Cys Ile Ala Ser Gly Val Pro Thr Pro Asp Ile Ala Trp 
                 245                250                255
Tyr Lys Lys Gly Gly Asp Leu Pro Ser Asp Lys Ala Lys Phe Glu Asn 
             260                265                270
Phe Asn Lys Ala Leu Arg Ile Thr Asn Val Ser Glu Glu Asp Ser Gly 
         275                280                285
Glu Tyr Phe Cys Leu Ala Ser Asn Lys Met Gly Ser Ile Arg His Thr 
     290                295                300
Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Leu Asp Glu Pro Lys 
 305                310                315                320
Asn Leu Ile Leu Ala Pro Gly Glu Asp Gly Arg Leu Val Cys Arg Ala 
                 325                330                335
Asn Gly Asn Pro Lys Pro Thr Val Gln Trp Leu Val Asn Gly Asp Pro 
             340                345                350
Leu Gln Ser Ala Pro Pro Asn Pro Asn Arg Glu Val Ala Gly Asp Thr 
         355                360                365
Ile Ile Phe Arg Asp Thr Gln Ile Ser Ser Arg Ala Val Tyr Gln Cys 
     370                375                380
Asn Thr Ser Asn Glu His Gly Tyr Leu Leu Ala Asn Ala Phe Val Ser 
 385                390                395                400
Val Leu Asp Val Pro Pro Arg Met Leu Ser Pro Arg Asn Gln Leu Ile 
                 405                410                415
Arg Val Ile Leu Tyr Asn Arg Thr Arg Leu Asp Cys Pro Phe Phe Gly 
             420                425                430
Ser Pro Ile Pro Thr Leu Arg Trp Phe Lys Asn Gly Gln Gly Ser Asn 
         435                440                445
Leu Asp Gly Gly Asn Tyr His Val Tyr Gln Asn Gly Ser Leu Glu Ile 
     450                455                460
Lys Met Ile Arg Lys Glu Asp Gln Gly Ile Tyr Thr Cys Val Ala Thr 
 465                470                475                480
Asn Ile Leu Gly Lys Ala Glu Asn Gln Val Arg Leu Glu Val Lys Asp 
                 485                490                495
Pro Thr Arg Ile Tyr Arg Met Pro Glu Asp Gln Val Ala Lys Arg Gly 
             500                505                510
Thr Thr Val Gln Leu Glu Cys Arg Val Lys His Asp Pro Ser Leu Lys 
         515                520                525
Leu Thr Val Ser Trp Leu Lys Asp Asp Glu Pro Leu Tyr Ile Gly Asn 
     530                535                540
Arg Met Lys Lys Glu Asp Asp Ser Leu Thr Ile Phe Gly Val Ala Glu 
 545                550                555                560
Arg Asp Gln Gly Ser Tyr Thr Cys Met Ala Ser Thr Glu Leu Asp Gln 
                 565                570                575
Asp Leu Ala Lys Ala Tyr Leu Thr Val Leu Ala Asp Gln Ala Thr Pro 
             580                585                590
Thr Asn Arg Leu Ala Ala Leu Pro Lys Gly Arg Pro Asp Arg Pro Arg 
         595                600                605
Asp Leu Glu Leu Thr Asp Leu Ala Glu Arg Ser Val Arg Leu Thr Trp 
     610                615                620
Ile Pro Gly Asp Asp Asn Asn Ser Pro Ile Thr Asp Tyr Val Val Gln 
 625                630                635                640
Phe Glu Glu Asp Gln Phe Gln Pro Gly Val Leu His Asp His Ser Lys 
                 645                650                655
Phe Pro Gly Ser Val Asn Ser Ala Val Leu His Leu Ser Pro Tyr Val 
             660                665                670
Asn Tyr Asp Phe Arg Val Ile Ala Val Asn Glu Val Gly Ser Ser His 
         675                680                685
Pro Ser Leu Pro Ser Glu Arg Tyr Arg Thr Ser Gly Ala Pro Pro Glu 
     690                695                700
Ser Asn Pro Ser Asp Val Lys Gly Glu Gly Thr Arg Lys Asn Asn Met 
 705                710                715                720
Glu Ile Thr Trp Thr Pro Met Asn Ala Thr Ser Ala Phe Gly Pro Asn 
                 725                730                735
Leu Arg Tyr Tyr Ile Val Lys Trp Arg Arg Arg Glu Thr Arg Glu Thr 
             740                745                750
Trp Asn Asn Val Thr Val Trp Gly Ser Arg Tyr Val Val Gly Gln Thr 
         755                760                765
Pro Val Tyr Val Pro Tyr Glu Ile Arg Val Gln Ala Glu Asn Asp Phe 
     770                775                780
Gly Lys Gly Pro Glu Pro Glu Thr Val Ile Gly Tyr Ser Gly Glu Asp 
 785                790                795                800
Leu Pro Ser Ala Pro Arg Arg Phe Arg Val Arg Gln Pro Asn Leu Glu 
                 805                810                815
Thr Ile Asn Leu Glu Trp Asp His Pro Glu His Pro Asn Gly Ile Leu 
             820                825                830
Ile Gly Tyr Thr Leu Arg Tyr Val Pro Phe Asn Gly Thr Lys Leu Gly 
         835                840                845
Lys Gln Met Val Glu Asn Phe Ser Pro Asn Gln Thr Lys Phe Ser Val 
     850                855                860
Gln Arg Ala Asp Pro Val Ser Arg Tyr Arg Phe Ser Leu Ser Ala Arg 
 865                870                875                880
Thr Gln Val Gly Ser Gly Glu Ala Ala Thr Glu Glu Ser Pro Thr Pro 
                 885                890                895
Pro Asn Glu Ala Thr Pro Thr Ala Ala Pro Pro Thr Leu Pro Pro Thr 
             900                905                910
Thr Val Gly Thr Thr Gly Leu Val Ser Ser Thr Asp Ala Thr Ala Leu 
         915                920                925
Ala Ala Thr Ser Glu Ala Thr Thr Val Pro Ile Ile Pro Thr Val Val 
     930                935                940
Pro Thr Thr Val Ala Thr Thr Ile Ala Thr Thr Thr Thr Thr Thr Ala 
 945                950                955                960
Ala Ala Thr Thr Thr Thr Thr Thr Glu Ser Pro Pro Thr Thr Thr Thr 
                 965                970                975
Gly Thr Lys Ile His Glu Thr Ala Pro Asp Glu Gln Ser Ile Trp Asn 
             980                985                990
Val Thr Val Leu Pro Asn Ser Lys Trp Ala Asn Ile Thr Trp Lys His 
         995                1000                1005
Asn Phe Arg Pro Gly Thr Asp Phe Val Val Glu Tyr Ile Asp Ser Asn 
     1010                1015                1020
His Thr Lys Lys Thr Val Pro Val Lys Ala Gln Ala Gln Pro Ile Gln 
 1025                1030                1035                1040
Leu Thr Asp Leu Phe Pro Gly Met Thr Tyr Thr Leu Arg Val Tyr Ser 
                 1045                1050                1055
Arg Asp Asn Glu Gly Ile Ser Ser Thr Val Ile Thr Phe Met Thr Ser 
             1060                1065                1070
Thr Ala Tyr Thr Asn Asn Gln Thr Asp Ile Ala Thr Gln Gly Trp Phe 
         1075                1080                1085
Ile Gly Leu Met Cys Ala Ile Ala Leu Leu Val Leu Ile Leu Leu Ile 
     1090                1095                1100
Val Cys Phe Ile Lys Arg Ser Arg Gly Gly Lys Tyr Pro Val Arg Glu 
 1105                1110                1115                1120
Lys Lys Asp Val Pro Leu Gly Pro Glu Asp Pro Lys Glu Glu Asp Gly 
                 1125                1130                1135
Ser Phe Asp Tyr Ser Asp Glu Asp Asn Lys Pro Leu Gln Gly Ser Gln 
             1140                1145                1150
Thr Ser Leu Asp Gly Thr Ile Lys Gln Gln Glu Ser Asp Asp Ser Leu 
         1155                1160                1165
Val Asp Tyr Gly Glu Gly Gly Glu Gly Gln Phe Asn Glu Asp Gly Ser 
     1170                1175                1180
Phe Ile Gly Gln Tyr Thr Val Arg Lys Asp Lys Glu Glu Thr Glu Gly 
 1185                1190                1195                1200
Asn Glu Ser Ser Glu Ala Thr Ser Pro Val Asn Ala Ile Tyr Ser Leu 
                 1205                1210                1215
Ala 
             1220



<210> 8966
<211> 4955
<212> DNA
<213> Homo sapiens
<308> AB018299
<400> 8966

ccaagcatt  agaatgagc  gacgcagcc  ccaaccatc  ccaagcagt  agcgaagga  60
cacatcgtg  acccccgtg  taacatcct  attgagtgt  aagcaaaag  gaaccctgc  120
cccagcttc  actggacac  aaacagcag  ttcttcaac  tcgccaagg  cccccgggt  180
tccatgagg  ggaggtctg  gaccctggt  attgacttc  gcagtggcg  gcggccgga  240
gaatatgag  gggaatatc  gtgcttcgc  cgcaacaaa  ttggcacgg  cctgtccaa  300
aggatccgc  tgcaggtgt  taaatctcc  ctgtggccc  aggaaaacc  agaccctgt  360
gtggtccaa  agggcgctc  tttgacgct  cagtgcaac  ccccgcctg  acttccatc  420
ccggtcatc  tctggatga  cagctccat  gagcccatc  cccaagaca  acgtgtctc  480
cagggccat  acggagacc  atacttctc  aacgtgatg  tgcaggaca  gcagaccga  540
tacagttgt  acgcccgct  ccacttcac  cacaccatc  agcagaaga  ccctttcac  600
ctcaaggtc  tcaccaccc  aggagttgc  gaaagaaca  caagcttca  gtatcccca  660
ggcaccgcg  gcagccaga  ggtgcttcg  ggcatggac  tcctgctgg  atgcatcgc  720
tccggggtc  caacaccag  catcgcatg  tacaagaaa  gtggggacc  cccatctga  780
aaggccaag  ttgagaact  taataaggc  ctgcgtatc  caaatgtct  tgaggaaga  840
tccggggag  atttctgcc  ggcctccaa  aagatgggc  gcatccggc  cacgatctc  900
gtgagagta  aggctgctc  ctactggct  gacgaaccc  agaacctta  tctggctcc  960
ggcgaggat  ggagactgg  gtgtcgagc  aatggaaac  ccaaaccca  tgtccagtg  1020
atggtgaat  gggaacctt  gcaatcggc  ccacctaac  caaaccgtg  ggtggccgg  1080
gacaccatc  tcttccggg  cacccagat  agcagcagg  ctgtgtacc  gtgcaacac  1140
tccaacgag  atggctacc  gctggccaa  gcctttgtc  gtgtgctgg  tgtgccgcc  1200
cggatgctg  cgccccgga  ccagctcat  cgagtgatt  tttacaacc  gacgcggct  1260
gactgccct  tctttgggt  tcccatccc  acactgcga  ggtttaaga  tgggcaagg  1320
agcaacctg  atggtggca  ctaccatgt  tatgagaac  gcagtctgg  aattaagat  1380
atccgcaaa  aggaccagg  catctacac  tgtgtcgcc  ccaacatcc  gggcaaagc  1440
gaaaaccaa  tccgcctgg  ggtcaaaga  cccaccagg  tctaccgga  gcccgagga  1500
caggtggcc  gaaggggca  cacggtgca  ctggagtgt  gggtgaagc  cgacccctc  1560
ctgaaactc  ccgtctcct  gctgaagga  gacgagccg  tctatattg  aaacaggat  1620
aagaaggaa  acgactccc  gaccatctt  ggggtggca  agcgggacc  gggcagtta  1680
acgtgtgtc  ccagcaccg  gctagacca  gacctggcc  aggcctacc  caccgtgct  1740
gctgatcag  ccactccaa  taaccgttt  gctgccctg  ccaaaggac  gccagaccg  1800
ccccgggac  tggagctga  cgacctggc  gagaggagc  tgcggctga  ctggatccc  1860
ggggatgct  acaacagcc  catcacaga  tacgtcgtc  agtttgaag  agaccagtt  1920
caacctggg  tctggcatg  ccatcccaa  taccccggc  gcgttaact  agccgtcct  1980
cggctgtcc  cgtatgtca  ctaccagtt  cgtgtcatt  ccatcaacg  ggttgggag  2040
agccacccc  gcctcccat  cgagcgcta  cgaaccagt  gagcacccc  cgagtccaa  2100
cctggtgac  tgaagggag  ggggaccag  aagaacaac  tggagatca  gtggacgcc  2160
atgaatgcc  cctcggcct  tggccccaa  ctgcgctac  ttgtcaagt  gaggcggag  2220
gagactcga  aggcctgga  caacgtcac  gtgtggggc  ctcgctacg  ggtggggca  2280
accccagtc  acgtgccct  tgagatccg  gtccaggct  aaaatgact  cgggaaggg  2340
cctgagcca  agtccgtca  cggttactc  ggagaagat  tacccagtg  ccctaggcg  2400
ttccgagtc  ggcagccca  cctggagac  atcaacctg  aatgggatc  tcctgagca  2460
ccaaatggg  tcatgattg  atacactct  aaatatgtg  cctttaacg  gaccaaagt  2520
ggaaagcag  tagtggaaa  cttctctcc  aatcagacc  agttcacgg  gcaaagaac  2580
gaccccgtg  cacgctacc  ctttaccct  agcgccagg  cgcaggtgg  ctctgggga  2640
gccgtcaca  aggagtcac  agcaccccc  aatgaagct  ctccaaccg  agcttacac  2700
aacaaccaa  cggacatcg  cacccaggg  tggttcatt  ggcttatgt  cgccatcgc  2760
ctcctggtg  tgatcctgc  catcgtctg  ttcatcaag  ggagtcgcg  cggcaagta  2820
ccagtacga  aaaagaagg  tgttcccct  ggccctgaa  accccaagg  agaggatgg  2880
tcatttgac  atagtgatg  ggacaacaa  cccctgcag  gcagtcaga  atctctgga  2940
ggcaccatc  agcagcagg  gagtgacga  agcctggtg  actatggcg  gggtggcga  3000
ggtcagttc  atgaagacg  ctccttcat  ggccagtac  cggtcaaaa  ggacaagga  3060
gaaacagag  gcaacgaaa  ctcagaggc  acgtcacct  tcaatgcta  ctactctct  3120
gcctaacgg  gcccaccca  gcacagcca  cactttgca  gtgggagga  gggagaagg  3180
gagacaaaa  cactgcaga  ctaccacga  gccaccacc  ccttcagta  caagggtac  3240
atatggggg  ctgccaagc  gtgaggacc  gtagccacc  agccaccca  aagccccct  3300
ccaatgacc  cccttcagc  ccgggtgcc  ccagtgtgg  agagctgga  ccgtggctg  3360
gctcagctg  agggagcct  gccccttgc  cggtctcgc  gccaccccg  gcgttccac  3420
acactgtcc  cccttggcc  cggcacacg  tcacctttt  tgttggtta  gggacttct  3480
attgtctta  tttcgcttt  tgcatcttc  cctccagac  caatgtctc  gttttcttt  3540
ccttttgaa  aagagtccc  ggaaaagaa  gaataagtg  attctcccc  aggagaatc  3600
tttttgcaa  gataggcaa  aaggattga  tccatacca  aacacgtag  caggctgta  3660
tattcaaac  acctctggg  caatgcatt  ccaaaggat  cctttctcg  catatgcct  3720
ccctggccc  cagcccctc  gcctcggcc  tgtcagttg  tgagctggg  ttggctcct  3780
tctggaaaa  gacagtatt  ttggcaggg  gaaggtgcg  aggcctcct  gctgctctc  3840
ggtttggtt  ggaggtgtg  ttacctctt  ctcctcatt  ctcccctgc  cttttctct  3900
gaatatcta  gatgtgagc  gcattgact  tgaagacgt  tgaggaaca  gagtgggca  3960
tgatagaaa  gacttcaac  ccagtgact  tgtacctcc  gcagaagaa  atcaggtgt  4020
tggtcttgg  ggcactgtg  tcacctcta  agagaagaa  aaggctggg  ttggacttc  4080
tgcctcctc  ctggtgaaa  ccaggatgt  gatagaggg  cacacccac  ctgtccaga  4140
tagagggca  ctgtccacg  ggccagggc  catgctgcc  ccctcgagg  gatggaacc  4200
tgtgatgca  aagctttgc  ggtgtgttt  gggcataag  cactgctcc  cttccatct  4260
tagcagata  catcttctc  gccaattct  taggacact  aggctcttg  ttgacatgg  4320
gtgtggatg  ggacttgcc  caagactga  caggtctgc  ctttcattg  ggtgtatac  4380
tatcagggg  ccctgaggt  gcaccgtac  cagtgttgt  atgccccca  ctagggagg  4440
ctcaatgct  tttgtatgc  ttatgcagc  ctgatctgt  cctggagtt  ccaggttcc  4500
agctccccc  ctgcaagcc  tgaagcctc  agcaacgtc  atctccagg  gagcagggc  4560
gcctatgca  gtgttccgg  aggaccaga  gtggccact  aacacacgt  ctcaccagt  4620
accccaaat  gagacactc  cagacctgc  gttctcaga  cgaaggtgc  gccttcatc  4680
tccccacct  atgcatttt  gaaaccaaa  gtacctagc  tcagagaca  agaaggaga  4740
ggggagatc  tgagtctaa  aggaaccct  tagctgttt  tgcagctga  gtcagtttc  4800
ggagggtga  gctgatccc  aggaatgga  cagctgcca  gggcacagc  tccgatttg  4860
gcctctccg  ctgccagcc  gggggcctg  gccagacca  ggctctgtc  ttccgtgac  4920
ttattaaag  aacatttgc  acatgttta  gccgc  4955



<210> 8967
<211> 836
<212> PRT
<213> Homo sapiens
<308> BAA34476
<400> 8967

His Asn Gly Asp Leu Tyr Phe Ser Asn Val Met Leu Gln Asp Met Gln 
  1               5                  10                  15
Thr Asp Tyr Ser Cys Asn Ala Arg Phe His Phe Thr His Thr Ile Gln 
             20                  25                  30
Gln Lys Asn Pro Phe Thr Leu Lys Val Leu Thr Thr Arg Gly Val Ala 
         35                  40                  45
Glu Arg Thr Pro Ser Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln 
     50                  55                  60
Met Val Leu Arg Gly Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly 
 65                  70                  75                  80
Val Pro Thr Pro Asp Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro 
                 85                  90                  95
Ser Asp Lys Ala Lys Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr 
             100                105                110
Asn Val Ser Glu Glu Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn 
         115                120                125
Lys Met Gly Ser Ile Arg His Thr Ile Ser Val Arg Val Lys Ala Ala 
     130                135                140
Pro Tyr Trp Leu Asp Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu 
 145                150                155                160
Asp Gly Arg Leu Val Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val 
                 165                170                175
Gln Trp Met Val Asn Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro 
             180                185                190
Asn Arg Glu Val Ala Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile 
         195                200                205
Ser Ser Arg Ala Val Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr 
     210                215                220
Leu Leu Ala Asn Ala Phe Val Ser Val Leu Asp Val Pro Pro Arg Met 
 225                230                235                240
Leu Ser Pro Arg Asn Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr 
                 245                250                255
Arg Leu Asp Cys Pro Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp 
             260                265                270
Phe Lys Asn Gly Gln Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val 
         275                280                285
Tyr Glu Asn Gly Ser Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln 
     290                295                300
Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn 
 305                310                315                320
Gln Val Arg Leu Glu Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro 
                 325                330                335
Glu Asp Gln Val Ala Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg 
             340                345                350
Val Lys His Asp Pro Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp 
         355                360                365
Asp Glu Pro Leu Tyr Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser 
     370                375                380
Leu Thr Ile Phe Gly Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys 
 385                390                395                400
Val Ala Ser Thr Glu Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr 
                 405                410                415
Val Leu Gly Arg Pro Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu 
             420                425                430
Ala Glu Arg Ser Val Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn 
         435                440                445
Ser Pro Ile Thr Asp Tyr Val Val Gln Phe Glu Glu Asp Gln Phe Gln 
     450                455                460
Pro Gly Val Trp His Asp His Ser Lys Tyr Pro Gly Ser Val Asn Ser 
 465                470                475                480
Ala Val Leu Arg Leu Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile 
                 485                490                495
Ala Ile Asn Glu Val Gly Ser Ser His Pro Ser Leu Pro Ser Glu Arg 
             500                505                510
Tyr Arg Thr Ser Gly Ala Pro Pro Glu Ser Asn Pro Gly Asp Val Lys 
         515                520                525
Gly Glu Gly Thr Arg Lys Asn Asn Met Glu Ile Thr Trp Thr Pro Met 
     530                535                540
Asn Ala Thr Ser Ala Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp 
 545                550                555                560
Arg Arg Arg Glu Thr Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly 
                 565                570                575
Ser Arg Tyr Val Val Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile 
             580                585                590
Arg Val Gln Ala Glu Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser 
         595                600                605
Val Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Arg Ala Ala Pro Thr Glu 
     610                615                620
Val Lys Val Arg Val Met Asn Ser Thr Ala Ile Ser Leu Gln Trp Asn 
 625                630                635                640
Arg Val Tyr Ser Asp Thr Val Gln Gly Gln Leu Arg Glu Tyr Arg Ala 
                 645                650                655
Tyr Tyr Trp Arg Glu Ser Ser Leu Leu Lys Asn Leu Trp Val Ser Gln 
             660                665                670
Lys Arg Gln Gln Ala Ser Phe Pro Gly Asp Arg Leu Arg Gly Val Val 
         675                680                685
Ser Arg Leu Phe Pro Tyr Ser Asn Tyr Lys Leu Glu Met Val Val Val 
     690                695                700
Asn Gly Arg Gly Asp Gly Pro Arg Ser Glu Thr Lys Glu Phe Thr Thr 
 705                710                715                720
Pro Glu Gly Val Pro Ser Ala Pro Arg Arg Phe Arg Val Arg Gln Pro 
                 725                730                735
Asn Leu Glu Thr Ile Asn Leu Glu Trp Asp His Pro Glu His Pro Asn 
             740                745                750
Gly Ile Met Ile Gly Tyr Thr Leu Lys Tyr Val Ala Phe Asn Gly Thr 
         755                760                765
Lys Val Gly Lys Gln Ile Val Glu Asn Phe Ser Pro Asn Gln Thr Lys 
     770                775                780
Phe Thr Val Gln Arg Thr Asp Pro Val Ser Arg Tyr Arg Phe Thr Leu 
 785                790                795                800
Ser Ala Arg Thr Gln Val Gly Ser Gly Glu Ala Val Thr Glu Glu Ser 
                 805                810                815
Pro Ala Pro Pro Asn Glu Gly Arg Cys Met Ala Ala Ala Pro Gly Val 
             820                825                830
Lys Gly Pro Ser 
         835



<210> 8968
<211> 4044
<212> DNA
<213> Rattus norvegicus
<308> U81037
<400> 8968

gctgatcag  ttaaaacca  gccgaagaa  aagcccttg  ctgcaggca  agcgcccct  60
tttctcttc  tgtgccaga  gatcagcgc  ctggatgtt  ctcttgatc  aaagctcct  120
gatgacttg  tacagcctc  aactatcac  caacagtca  caaaagact  catcattga  180
ccacgggag  atattgtaa  ccaatgtga  gccaaaggg  aacctcctc  aagcttttc  240
tggactcgt  acggaacac  ttttgacat  gacaaagac  ctctggtca  tatgaagcc  300
ggctcagga  cccttgtca  caacatcat  agtgaagga  aggcggaga  ctatgaagg  360
gtttaccag  gcactgcaa  gaatgagcg  ggagctgct  tctccaata  cattgttgt  420
cgcccctct  ggtcaccct  gtggaccaa  gaaagactt  aaccaataa  cctccgaag  480
ggtcagtca  tagtactac  atgtaggcc  ccaattgga  taccaccgg  cataatatt  540
tggatggat  actcctttc  aagactgcc  cagagtgag  gggtttccc  aggactgaa  600
ggagacctt  acttctcca  tgtcctccc  gaggacacc  gtgaggact  catctgcta  660
gccagattt  atcacactc  aacaattca  cagaaacaa  ctatttctc  gaaggtgat  720
tcagtggat  aattgaatg  cactatagc  gctaatttg  gtgacactg  gttttatgg  780
gctaaatct  gtaaagaga  gccaccaac  tttctaact  cagagggca  tgaaagtca  840
aaggaagaa  taagaggaa  cgtgctttc  ctggagtgc  ttgcagaag  cctacctac  900
ccagttatt  actggatca  ggaagatgg  acgcttcct  tcaaccgga  gttttatcg  960
aactttaag  aaaccttgc  gatcattca  gtctctgaa  cagactctg  aaattatca  1020
tgcatagca  aaaacgcat  gggagccgt  catcatacc  tttctgtca  agttaaagc  1080
gctccctac  ggattgttg  acctcacaa  ctcgtgctt  ccccagggg  gaatgggac  1140
ctcatctgc  gagctaacg  caacccaaa  cccagaatt  gctggttaa  aaatggagt  1200
ccagtagaa  ttgctctcg  tgaccccag  cgaaaaatc  atggtgata  cattatgtt  1260
tcaaatgtt  aagaaagct  aagtgcggt  tatcagtgc  atgcctcta  caaatatgg  1320
tatttacta  caaatgcat  tgtaaatgt  ctcgctgaa  cacctcgga  tcttacctc  1380
gcaaacaca  tgtaccagg  cattgcaaa  cggcctgct  tgctggact  tgccttctt  1440
gggtctcct  tgcctacca  tgagtggtt  aaaggaact  aaggaagcg  tcttcacga  1500
gacatttat  ttttacatg  taacggaac  ctagaaatt  ctgtggccc  aaaggatag  1560
acagggaca  atacttgtg  cgcaaggaa  aaattaggg  tggcaaaga  tgaagttca  1620
ttggaaatc  aagatccaa  caggttcat  aaacaacct  gatatgcag  cgttcagag  1680
gggagcaag  tttcctttg  atgcaaagt  aaacacgac  acaccttaa  ccccaccat  1740
ctgtggctg  aggacaatg  agagctgcc  aatgatgaa  ggttctctg  cgacaagga  1800
catctggtg  tctctgacg  aaaggatga  gatggtggg  cctacacat  tgcagccaa  1860
acaacgctg  acagtgttt  agccagcgc  gtgctcagg  tggtcgctc  tactccaac  1920
ccagccccc  tttacgatg  cccgaatcc  ccctttgat  tagaattga  caatcaact  1980
gacaaaagt  ttcagctga  atggacccc  ggcgatgac  acaatagtc  cattacaaa  2040
ttcatcatc  agtatgaag  tgcaatgca  gaggcaggg  tgtggcgcc  ccaggcgga  2100
gtttctgga  cgcagacca  agcccagct  aagctgtct  cctatgtga  ctactcctt  2160
cgagtcatg  cggagaaca  catcgggag  agtgtgcca  gcgaggcat  ggagcagta  2220
cttacaaag  ccgcggaac  agaccagaa  cccacggct  tggaaggac  agggacaga  2280
ccggacaac  tggtgatca  atggaagcc  ctgaatggt  ttcaatcga  tgggcccgg  2340
ctccagtac  aagtgagct  gcgtcagaa  gatggtgac  atgaatgga  gtctgtggt  2400
gtggccaat  tatccaaat  cattgtttc  ggcacacca  cttttgtcc  atacctgat  2460
aaagttcaa  ccctgaatg  tgtgggctt  gctccagag  cagctgcag  catgggaca  2520
tccggagaa  accttccaa  ggtggctcc  ggaaatgtg  gtgtcagtg  ggtgaacag  2580
accttggca  aggcacact  ggaccctgt  cctcccaag  gtgtccgag  acacttaca  2640
ggctaccgg  tttactact  gaaggctca  agctcatct  aaagaaaca  acgccacat  2700
gagaagaag  tcctcacct  ccagggcag  aagactcac  gcatgctgc  agggctgca  2760
ccttacagt  actatgttc  caatgtccg  gtggtcaat  ggaaagggg  gggcccagc  2820
agcgccgac  gaggcttcc  tactccaga  ggagtccct  gtgctccct  atctttgaa  2880
attgttaat  ctacactgg  ctctctcac  ttggaatgg  accctccaa  ccacccaaa  2940
ggtatcctg  ctgaataca  cttaaaata  cagccaatt  atagcacac  cgaactagg  3000
cctctggta  atttaaaaa  tcctgccaa  aagacacgc  ggactttga  aaatttaaa  3060
ttcagcact  ggtacaagt  ctacttcta  gcacaaaca  cagtgggat  gggcagtca  3120
atcacagag  aagcaataa  aactgtgga  gaaggtaag  aggctggta  tcttccacc  3180
gatgtaggt  caggcaaag  aatggcaag  cggcaagtg  atattgcga  ccaaggctg  3240
ttcataggt  taatgtgtg  tgttgccct  ctcatctta  ttttgctaa  cgtttgctt  3300
atcagaaga  acaagggtg  taaatatcc  gttaaagaa  aggaggatg  tcacgcaga  3360
cctgaaatc  agcccatga  ggaggatga  ggaacgttt  gagaatata  tgatgcaga  3420
gatcacaag  ctttgaaaa  gggaagtcg  acaccttca  acaggactg  gaaaaaaga  3480
gatagtgat  acagcctgg  tgactatgg  gagggggtg  atggccaat  caatgagga  3540
ggctccttt  tcggacaat  cagtggtaa  aaagagaaa  aaccagcag  gggaaatga  3600
agctcagag  ccccttctc  tgtcaacgc  atgaactcc  ttgtttaag  ctttaagct  3660
tgtgccaat  tcccatctc  ctggaatgg  tttcctgaa  acttgtcat  cctctcata  3720
tatggacat  tgggtagaa  gaatgtttt  tgcggtata  gagtattat  agaacagag  3780
aagaacata  ctcagtcag  tgatacgtt  atatgaact  gggtgaaaa  gcatacttt  3840
tgttcagag  gggttttct  aatttcctt  gaactgatt  aaaagaact  caacatcat  3900
aatagctta  attattccc  gtgcaggat  cagttcaat  agatgcatg  aacatgctg  3960
acagaggac  tagctgtgt  tgtgattgc  acgtggttg  gtacttcgt  gacactatc  4020
tcagctgaa  cctaaatat  aatt  4044



<210> 8969
<211> 1215
<212> PRT
<213> Rattus norvegicus
<308> AAB47755
<400> 8969

Ala Asp Gln Leu Lys Thr Met Pro Lys Lys Lys Pro Leu Ser Ala Gly 
  1               5                  10                  15
Arg Ala Pro Leu Phe Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Asp 
             20                  25                  30
Val Pro Leu Asp Pro Lys Leu Leu Asp Asp Leu Val Gln Pro Pro Thr 
         35                  40                  45
Ile Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn 
     50                  55                  60
Ile Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser 
 65                  70                  75                  80
Trp Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val 
                 85                  90                  95
Thr Met Lys Pro Gly Ser Gly Thr Leu Val Ile Asn Ile Met Ser Glu 
             100                105                110
Gly Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn 
         115                120                125
Glu Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg 
     130                135                140
Ser Pro Leu Trp Thr Lys Glu Arg Leu Glu Pro Ile Ile Leu Arg Ser 
 145                150                155                160
Gly Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro 
                 165                170                175
Ala Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser 
             180                185                190
Glu Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val 
         195                200                205
Leu Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn 
     210                215                220
His Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Leu Lys Val Ile 
 225                230                235                240
Ser Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr 
                 245                250                255
Glu Phe Tyr Gly Ala Lys Ser Ser Lys Glu Arg Pro Pro Thr Phe Leu 
             260                265                270
Thr Pro Glu Gly Asn Glu Ser His Lys Glu Glu Leu Arg Gly Asn Val 
         275                280                285
Leu Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Val Ile Tyr 
     290                295                300
Trp Ile Lys Glu Asp Gly Thr Leu Pro Val Asn Arg Thr Phe Tyr Arg 
 305                310                315                320
Asn Phe Lys Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser 
                 325                330                335
Gly Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Val His His 
             340                345                350
Thr Ile Ser Val Thr Val Lys Ala Ala Pro Tyr Trp Ile Val Ala Pro 
         355                360                365
His Asn Leu Val Leu Ser Pro Gly Glu Asn Gly Thr Leu Ile Cys Arg 
     370                375                380
Ala Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val 
 385                390                395                400
Pro Val Glu Ile Ala Leu Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp 
                 405                410                415
Thr Ile Met Phe Ser Asn Val Gln Glu Ser Ser Ser Ala Val Tyr Gln 
             420                425                430
Cys Asn Ala Ser Asn Lys Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val 
         435                440                445
Asn Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Ser Ala Asn Thr Leu 
     450                455                460
Tyr Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe 
 465                470                475                480
Gly Ser Pro Met Pro Thr Ile Glu Trp Phe Lys Gly Thr Lys Gly Ser 
                 485                490                495
Ala Leu His Glu Asp Ile Tyr Val Leu His Asp Asn Gly Thr Leu Glu 
             500                505                510
Ile Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala 
         515                520                525
Arg Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys 
     530                535                540
Asp Pro Thr Arg Phe Ile Lys Gln Pro Gly Tyr Ala Val Val Gln Arg 
 545                550                555                560
Gly Ser Lys Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu 
                 565                570                575
Ile Pro Thr Ile Leu Trp Leu Lys Asp Asn Gly Glu Leu Pro Asn Asp 
             580                585                590
Glu Arg Phe Ser Val Asp Lys Asp His Leu Val Val Ser Asp Val Lys 
         595                600                605
Asp Glu Asp Gly Gly Thr Tyr Thr Cys Ala Ala Asn Thr Thr Leu Asp 
     610                615                620
Ser Val Ser Ala Ser Ala Val Leu Arg Val Val Ala Pro Thr Pro Thr 
 625                630                635                640
Pro Ala Pro Ile Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu 
                 645                650                655
Thr Asn Gln Leu Asp Lys Ser Val Gln Leu Thr Trp Thr Pro Gly Asp 
             660                665                670
Asp Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala 
         675                680                685
Met His Glu Ala Gly Leu Trp Arg His Gln Ala Glu Val Ser Gly Thr 
     690                695                700
Gln Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe 
 705                710                715                720
Arg Val Met Ala Glu Asn Ser Ile Gly Arg Ser Val Pro Ser Glu Ala 
                 725                730                735
Ser Glu Gln Tyr Leu Thr Lys Ala Ala Glu Pro Asp Gln Asn Pro Thr 
             740                745                750
Ala Val Glu Gly Leu Gly Thr Glu Pro Asp Asn Leu Val Ile Thr Trp 
         755                760                765
Lys Pro Leu Asn Gly Phe Gln Ser Asn Gly Pro Gly Leu Gln Tyr Lys 
     770                775                780
Val Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val 
 785                790                795                800
Val Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val 
                 805                810                815
Pro Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Val Gly Phe Ala Pro 
             820                825                830
Glu Pro Ala Ala Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val 
         835                840                845
Ala Pro Gly Asn Val Arg Val Ser Val Val Asn Ser Thr Leu Ala Glu 
     850                855                860
Ala His Trp Asp Pro Val Pro Pro Lys Ser Val Arg Gly His Leu Gln 
 865                870                875                880
Gly Tyr Arg Ile Tyr Tyr Trp Lys Ala Gln Ser Ser Ser Lys Arg Asn 
                 885                890                895
Arg Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr 
             900                905                910
His Gly Met Leu Pro Gly Leu Gln Pro Tyr Ser His Tyr Val Leu Asn 
         915                920                925
Val Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Ala Asp Arg 
     930                935                940
Gly Phe His Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys 
 945                950                955                960
Ile Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro 
                 965                970                975
Ser His Pro Asn Gly Ile Leu Thr Glu Tyr Ile Leu Lys Tyr Gln Pro 
             980                985                990
Ile Asn Ser Thr His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro 
         995                1000                1005
Ala Asn Lys Thr Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg 
     1010                1015                1020
Tyr Lys Phe Tyr Phe Tyr Ala Gln Thr Ser Val Gly Ser Gly Ser Gln 
 1025                1030                1035                1040
Ile Thr Glu Glu Ala Ile Thr Thr Val Asp Glu Gly Lys Lys Ala Gly 
                 1045                1050                1055
Ile Leu Pro Pro Asp Val Gly Ala Gly Lys Ala Met Ala Ser Arg Gln 
             1060                1065                1070
Val Asp Ile Ala Thr Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Val 
         1075                1080                1085
Ala Leu Leu Ile Leu Ile Leu Leu Ile Val Cys Phe Ile Arg Arg Asn 
     1090                1095                1100
Lys Gly Gly Lys Tyr Pro Val Lys Glu Lys Glu Asp Ala His Ala Asp 
 1105                1110                1115                1120
Pro Glu Ile Gln Pro Met Lys Glu Asp Asp Gly Thr Phe Gly Glu Tyr 
                 1125                1130                1135
Ser Asp Ala Glu Asp His Lys Pro Leu Lys Lys Gly Ser Arg Thr Pro 
             1140                1145                1150
Ser Asp Arg Thr Val Lys Lys Glu Asp Ser Asp Asp Ser Leu Val Asp 
         1155                1160                1165
Tyr Gly Glu Gly Val Asn Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile 
     1170                1175                1180
Gly Gln Tyr Ser Gly Lys Lys Glu Lys Glu Pro Ala Glu Gly Asn Glu 
 1185                1190                1195                1200
Ser Ser Glu Ala Pro Ser Pro Val Asn Ala Met Asn Ser Phe Val 
                 1205                1210                1215



<210> 8971
<211> 1180
<212> PRT
<213> Homo sapiens
<308> NP_005001
<400> 8971

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
  1               5                  10                  15
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
             20                  25                  30
Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile 
         35                  40                  45
Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile 
     50                  55                  60
Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp 
 65                  70                  75                  80
Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr 
                 85                  90                  95
Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
             100                105                110
Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu 
         115                120                125
Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser 
     130                135                140
Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly 
 145                150                155                160
Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro 
                 165                170                175
Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu 
             180                185                190
Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu 
         195                200                205
Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His 
     210                215                220
Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser 
 225                230                235                240
Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly 
                 245                250                255
Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu 
             260                265                270
Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu 
         275                280                285
Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys 
     290                295                300
Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln 
 305                310                315                320
Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val 
                 325                330                335
Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val 
             340                345                350
Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn 
         355                360                365
Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile 
     370                375                380
Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe 
 385                390                395                400
Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser 
                 405                410                415
Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala 
             420                425                430
Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile 
         435                440                445
Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu 
     450                455                460
Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu 
 465                470                475                480
Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala 
                 485                490                495
Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu 
             500                505                510
Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp Ala Thr Trp 
         515                520                525
Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val 
     530                535                540
Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val 
 545                550                555                560
Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr 
                 565                570                575
Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser 
             580                585                590
Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala 
         595                600                605
Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val 
     610                615                620
Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu 
 625                630                635                640
Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser 
                 645                650                655
Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met His Lys Pro 
             660                665                670
Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala 
         675                680                685
Gln Leu Asn Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala 
     690                695                700
Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr 
 705                710                715                720
Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly 
                 725                730                735
Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys Pro Leu Asn 
             740                745                750
Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg 
         755                760                765
Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val 
     770                775                780
Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile 
 785                790                795                800
Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val 
                 805                810                815
Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn 
             820                825                830
Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp 
         835                840                845
Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile 
     850                855                860
Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile 
 865                870                875                880
Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu 
                 885                890                895
Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val 
             900                905                910
Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr 
         915                920                925
Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro 
     930                935                940
Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn 
 945                950                955                960
Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr 
                 965                970                975
His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala Asn Lys Thr 
             980                985                990
Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr Lys Phe Tyr 
         995                1000                1005
Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile Thr Glu Glu 
     1010                1015                1020
Ala Val Thr Thr Val Asp Glu Ala Met Ala Ser Arg Gln Val Asp Ile 
 1025                1030                1035                1040
Ala Thr Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu 
                 1045                1050                1055
Ile Leu Ile Leu Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly 
             1060                1065                1070
Lys Tyr Pro Val Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile 
         1075                1080                1085
Gln Pro Met Lys Glu Asp Asp Gly Thr Phe Gly Glu Tyr Ser Asp Ala 
     1090                1095                1100
Glu Asp His Lys Pro Leu Lys Lys Gly Ser Arg Thr Pro Ser Asp Arg 
 1105                1110                1115                1120
Thr Val Lys Lys Glu Asp Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu 
                 1125                1130                1135
Gly Val Asn Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr 
             1140                1145                1150
Ser Gly Lys Lys Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser Glu 
         1155                1160                1165
Ala Pro Ser Pro Val Asn Ala Met Asn Ser Phe Val 
     1170                1175                1180



<210> 8972
<211> 1830
<212> DNA
<213> Rattus norvegicus
<308> U81186
<400> 8972

tggcgagtt  tggagcgcg  tctcccggc  gccggcttc  tatactggg  gggcgcgag  60
accattgct  acctgaccc  gcgagcctc  tactcgctc  tcagggcct  ccaggtgtg  120
tgcgtgggc  accaggcct  tgtcggccc  cggctcgga  aatgggcag  tgttacagg  180
ggcactgat  gaattggaa  atcatatgc  gaagagtta  caaagcgtg  aatgaagat  240
gtcttgata  gcagatccc  ggataaact  aaggaagtt  ccaacaaca  caaagaaaa  300
ttcaacgtt  aaacaagga  cattgctgt  gacttttca  tggatgata  ttatgataa  360
attaagaca  gcctgtctg  tcttgaaat  ggcgtttta  tgaacaacg  gggcatgtc  420
tacgagtat  cagaatact  tttggaaat  cctgacttg  acaacacca  caagaaact  480
ataaatatt  atgtgcttt  catttgcaa  gtgacacgc  tggtgctgc  tggcatggt  540
gagagatct  aaggggtga  tctcaacat  tcctctgcc  gtggcatgc  cccggttcc  600
ctgttgaca  tctactctg  aaccaaggc  tttgtagat  tcttctctc  gtgcctcca  660
gaggagtat  agagcaagg  catctttgt  cagagtgtc  tgccattct  tgtatctac  720
aaactggca  aaatacgga  gccgacttt  gataagccc  ctgcagaga  atttgtgaa  780
tctgcaatt  aaacagtag  tctgcagac  cgaaccact  ggatatgtg  tccacgcca  840
catgggctc  ataaactca  tcttgcccc  ttggattta  tttaaaacg  tcatgggtt  900
caacaagtc  ttgcggaat  gctatctga  gaaaaccaa  aagaactaa  ttctgctgg  960
tcatcgagc  ccttggcca  acgcttgac  tgtgcttgc  tactgggcc  ctgcctgtc  1020
ccagagtct  tactgtcat  tcagtaatt  ctaacatgg  atagctggc  gaaagcaaa  1080
tccttttag  ggttcctaa  atatattct  gatacaacc  ggagtaatt  gaagtttaa  1140
ataaatgtt  ttggcaaat  tatgtatac  actttgaca  aaaggaaca  atcccagaa  1200
gacagacgt  gcacccatc  ggcccagaa  gccaatgat  acctaatat  tggtctgga  1260
cctactata  agtgtaata  ctagctact  ttttatttt  aacattaaa  ggaatgggg  1320
ttagttgat  tttttttta  gggcagata  aatgcagtt  acattgatt  ctgtaaggt  1380
ttctaaagg  atgttccag  ttatgtgtt  ctatggaac  ggtcttctt  aaagtagct  1440
agaaagaca  aaagagaat  gaaacacgg  gttctttct  acacagaag  ccacaaaat  1500
ttattcttg  aacacacat  atgtctgct  tgttccatg  atgtaaata  tgaatgcta  1560
atagtgtga  tgaaatgta  aggtaagtg  gcccaagtg  acatcaaga  cagcaacat  1620
ctgtggtac  gtgggatcc  gaagagcag  ctgcctgga  atccagtgt  ggtcatgtc  1680
gtactgcac  catactatt  gcctaggat  acagactcc  tctgtggta  tgaggggtc  1740
tggaaacat  ttcttttta  gttggtgtc  catttgaat  catatatcc  cttttaata  1800
aagatgatg  aaccgcaaa  aaaaaaaaaa  1830



<210> 8973
<211> 291
<212> PRT
<213> Rattus norvegicus
<308> AAD00504
<400> 8973

Met Glu Arg Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala 
  1               5                  10                  15
Ser Thr Ile Ala Tyr Leu Thr Leu Arg Ala Ser Tyr Ser Leu Phe Arg 
             20                  25                  30
Ala Phe Gln Val Trp Cys Val Gly Asn Gln Ala Phe Val Gly Pro Arg 
         35                  40                  45
Leu Gly Glu Trp Ala Val Val Thr Gly Gly Thr Asp Gly Ile Gly Lys 
     50                  55                  60
Ser Tyr Ala Glu Glu Leu Ala Lys Arg Gly Met Lys Ile Val Leu Ile 
 65                  70                  75                  80
Ser Arg Ser Gln Asp Lys Leu Lys Glu Val Ser Asn Asn Ile Lys Glu 
                 85                  90                  95
Lys Phe Asn Val Glu Thr Arg Thr Ile Ala Val Asp Phe Ser Leu Asp 
             100                105                110
Asp Ile Tyr Asp Lys Ile Lys Thr Gly Leu Ser Gly Leu Glu Ile Gly 
         115                120                125
Val Leu Val Asn Asn Val Gly Met Ser Tyr Glu Tyr Pro Glu Tyr Phe 
     130                135                140
Leu Glu Ile Pro Asp Leu Asp Asn Thr Ile Lys Lys Leu Ile Asn Ile 
 145                150                155                160
Asn Val Leu Ser Ile Cys Lys Val Thr Arg Leu Val Leu Pro Gly Met 
                 165                170                175
Val Glu Arg Ser Lys Gly Val Ile Leu Asn Ile Ser Ser Ala Ser Gly 
             180                185                190
Met Leu Pro Val Pro Leu Leu Thr Val Tyr Ser Ala Thr Lys Ala Phe 
         195                200                205
Val Asp Phe Phe Ser Gln Cys Leu His Glu Glu Tyr Lys Ser Lys Gly 
     210                215                220
Ile Phe Val Gln Ser Val Leu Pro Phe Phe Val Ser Thr Lys Leu Ala 
 225                230                235                240
Lys Ile Arg Lys Pro Thr Leu Asp Lys Pro Ser Ala Glu Thr Phe Val 
                 245                250                255
Lys Ser Ala Ile Lys Thr Val Gly Leu Gln Thr Arg Thr Thr Gly Ile 
             260                265                270
Cys Asp Pro Arg His His Gly Leu Asn Lys Leu Asn Leu Ala Pro Leu 
         275                280                285
Asp Leu Phe 
     290



<210> 8974
<211> 2393
<212> DNA
<213> Homo sapiens
<308> NM_016142
<400> 8974

ggccggcgc  tcctcctgg  ttcattcac  cgctctttt  attcacgaa  gtagtgagg  60
ctagtggaa  gccatggag  gcgctctcc  cgccgccgg  ttcctgtac  gggtcggcg  120
gggcaccgt  gcctaccta  ccctgcgta  ttcgtactc  ctcttcacg  ccctccggg  180
ctggggagt  gggaatgag  cgggggtcg  cccggggct  ggagagtgg  cagttgtca  240
aggtagtac  gatggaatt  gaaaatcat  tgcagaaga  ttagcaaag  atggaatga  300
ggttgtcct  atcagcaga  caaaggata  acttgacca  gtttccagt  aaataaaag  360
aaaattcaa  gtggagaca  gaaccattg  tgttgactt  gcatcagaa  atatttatg  420
taaaattaa  acaggcttg  ctggtcttg  aatcggcat  ttagtgaac  acgtgggaa  480
gtcgtatga  tatcctgaa  actttttgg  tgttcctga  ttggacaat  tgatcaaga  540
aatgataaa  attaatatt  tttctgttt  taagatgac  caattggta  tgcctggca  600
ggtggaaag  tccaaaggg  ctattctga  catttcatc  ggcagtggc  tgctccctg  660
cccactctt  accatctat  ctgcaacca  gacttttgt  gatttcttc  ctcagtgcc  720
ccatgagga  tataggagc  agggcgtct  tgtgcagag  gtcctgcca  acttcgtag  780
tacaaaact  gctaaaatc  ggaagccaa  tttggataa  ccctctccg  agacgtttg  840
gaagtctgc  attaaaaca  tcggcctgc  atcccgaac  aatggatac  tgatccatg  900
tcttatggg  tcgataatc  caaacctgc  ttcttggat  tatttgaaa  tagtcatga  960
tatgaacaa  tctacacgg  ctcactatc  gaagaaaac  aagaagaac  aagcatgat  1020
actgcattg  aacttggcc  gatgctcca  catatgcac  ttcactgca  agcacccta  1080
tggttttga  aatctgacc  tgtcatttc  atagttatt  acatgacta  atattatct  1140
aattaagag  aaaatagaa  ttgctttta  gggtttctg  catatattc  ggatactat  1200
cgaggtaat  ttgaagttt  atataaatg  tcatatcaa  tgaatatag  actaatatt  1260
tcgggaaca  ctaatagaa  ggaatacta  tatagcaaa  cacagaatg  tagactcaa  1320
cataaaact  ggcagtttt  tctgcttca  aatgccatt  atcattatt  ctgtatttt  1380
tctgaaact  attataaaa  ccaatgtcc  gctactctt  tgtttttga  acttgaaga  1440
atggagatc  atttgattt  tttataagc  gacacactg  aatttacaa  gatctcttt  1500
cggttttat  aaattatct  ccagtttgt  catttatat  gaattgttc  ttatcaagg  1560
tagctaatg  catgaaaat  attgtgaaa  atggaatta  ttctgacac  tgaagccca  1620
taaactatg  tttcctata  tgcatattt  ttctcagtt  aaatgtatg  aaatatcga  1680
gctatatgg  atgatttat  aagataaat  ggccaaagt  tacattgag  ctggcagcc  1740
tctatggta  cactgaaac  ctgacccag  aaagtggct  gcttggaca  ccagctgcc  1800
ttgtttctg  attaaacca  tattgatca  acatatgac  caggctagt  ctataaaag  1860
aatgacttc  tagaaatgg  attataatt  ttaagttga  actctacag  tagctattg  1920
tataattag  tttaataaa  catgctgca  ccatggtat  caacaaaaa  acatttctt  1980
ggtgattga  attaaggcc  tatttacaa  gacttaata  aagactgac  tttatcctg  2040
ttcataact  gtatggaga  ctcaccaag  aagaattca  tactgtgaa  tatgcagca  2100
gaagattgg  ctttaccta  gctgtgttt  ctaagctct  agttttcag  accagtaga  2160
ttgtattaa  agaaaaaaa  atggggcct  agcttctgg  ttttaattt  gccagctaa  2220
gacataaaa  aaaaataaa  aaacaaaaa  aaatagcca  ctgctatca  catcattat  2280
taaaagaaa  tatatttta  cccctaaaa  taggaagaa  gtaatctca  aataaaggt  2340
gtcatttaa  ttgaataaa  atatagctt  atgaaaaac  caaaaaaaa  aaa  2393



<210> 8975
<211> 312
<212> PRT
<213> Homo sapiens
<308> NP_057226
<400> 8975

Met Glu Ser Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala 
  1               5                  10                  15
Gly Thr Val Ala Tyr Leu Ala Leu Arg Ile Ser Tyr Ser Leu Phe Thr 
             20                  25                  30
Ala Leu Arg Val Trp Gly Val Gly Asn Glu Ala Gly Val Gly Pro Gly 
         35                  40                  45
Leu Gly Glu Trp Ala Val Val Thr Gly Ser Thr Asp Gly Ile Gly Lys 
     50                  55                  60
Ser Tyr Ala Glu Glu Leu Ala Lys His Gly Met Lys Val Val Leu Ile 
 65                  70                  75                  80
Ser Arg Ser Lys Asp Lys Leu Asp Gln Val Ser Ser Glu Ile Lys Glu 
                 85                  90                  95
Lys Phe Lys Val Glu Thr Arg Thr Ile Ala Val Asp Phe Ala Ser Glu 
             100                105                110
Asp Ile Tyr Asp Lys Ile Lys Thr Gly Leu Ala Gly Leu Glu Ile Gly 
         115                120                125
Ile Leu Val Asn Asn Val Gly Met Ser Tyr Glu Tyr Pro Glu Tyr Phe 
     130                135                140
Leu Asp Val Pro Asp Leu Asp Asn Val Ile Lys Lys Met Ile Asn Ile 
 145                150                155                160
Asn Ile Leu Ser Val Cys Lys Met Thr Gln Leu Val Leu Pro Gly Met 
                 165                170                175
Val Glu Arg Ser Lys Gly Ala Ile Leu Asn Ile Ser Ser Gly Ser Gly 
             180                185                190
Met Leu Pro Val Pro Leu Leu Thr Ile Tyr Ser Ala Thr Lys Thr Phe 
         195                200                205
Val Asp Phe Phe Ser Gln Cys Leu His Glu Glu Tyr Arg Ser Lys Gly 
     210                215                220
Val Phe Val Gln Ser Val Leu Pro Tyr Phe Val Ala Thr Lys Leu Ala 
 225                230                235                240
Lys Ile Arg Lys Pro Thr Leu Asp Lys Pro Ser Pro Glu Thr Phe Val 
                 245                250                255
Lys Ser Ala Ile Lys Thr Val Gly Leu Gln Ser Arg Thr Asn Gly Tyr 
             260                265                270
Leu Ile His Ala Leu Met Gly Ser Ile Ile Ser Asn Leu Pro Ser Trp 
         275                280                285
Ile Tyr Leu Lys Ile Val Met Asn Met Asn Lys Ser Thr Arg Ala His 
     290                295                300
Tyr Leu Lys Lys Thr Lys Lys Asn 
 305                310



<210> 8976
<211> 1830
<212> DNA
<213> Rattus norvegicus
<308> U81186
<400> 8976

tggcgagtt  tggagcgcg  tctcccggc  gccggcttc  tatactggg  gggcgcgag  60
accattgct  acctgaccc  gcgagcctc  tactcgctc  tcagggcct  ccaggtgtg  120
tgcgtgggc  accaggcct  tgtcggccc  cggctcgga  aatgggcag  tgttacagg  180
ggcactgat  gaattggaa  atcatatgc  gaagagtta  caaagcgtg  aatgaagat  240
gtcttgata  gcagatccc  ggataaact  aaggaagtt  ccaacaaca  caaagaaaa  300
ttcaacgtt  aaacaagga  cattgctgt  gacttttca  tggatgata  ttatgataa  360
attaagaca  gcctgtctg  tcttgaaat  ggcgtttta  tgaacaacg  gggcatgtc  420
tacgagtat  cagaatact  tttggaaat  cctgacttg  acaacacca  caagaaact  480
ataaatatt  atgtgcttt  catttgcaa  gtgacacgc  tggtgctgc  tggcatggt  540
gagagatct  aaggggtga  tctcaacat  tcctctgcc  gtggcatgc  cccggttcc  600
ctgttgaca  tctactctg  aaccaaggc  tttgtagat  tcttctctc  gtgcctcca  660
gaggagtat  agagcaagg  catctttgt  cagagtgtc  tgccattct  tgtatctac  720
aaactggca  aaatacgga  gccgacttt  gataagccc  ctgcagaga  atttgtgaa  780
tctgcaatt  aaacagtag  tctgcagac  cgaaccact  ggatatgtg  tccacgcca  840
catgggctc  ataaactca  tcttgcccc  ttggattta  tttaaaacg  tcatgggtt  900
caacaagtc  ttgcggaat  gctatctga  gaaaaccaa  aagaactaa  ttctgctgg  960
tcatcgagc  ccttggcca  acgcttgac  tgtgcttgc  tactgggcc  ctgcctgtc  1020
ccagagtct  tactgtcat  tcagtaatt  ctaacatgg  atagctggc  gaaagcaaa  1080
tccttttag  ggttcctaa  atatattct  gatacaacc  ggagtaatt  gaagtttaa  1140
ataaatgtt  ttggcaaat  tatgtatac  actttgaca  aaaggaaca  atcccagaa  1200
gacagacgt  gcacccatc  ggcccagaa  gccaatgat  acctaatat  tggtctgga  1260
cctactata  agtgtaata  ctagctact  ttttatttt  aacattaaa  ggaatgggg  1320
ttagttgat  tttttttta  gggcagata  aatgcagtt  acattgatt  ctgtaaggt  1380
ttctaaagg  atgttccag  ttatgtgtt  ctatggaac  ggtcttctt  aaagtagct  1440
agaaagaca  aaagagaat  gaaacacgg  gttctttct  acacagaag  ccacaaaat  1500
ttattcttg  aacacacat  atgtctgct  tgttccatg  atgtaaata  tgaatgcta  1560
atagtgtga  tgaaatgta  aggtaagtg  gcccaagtg  acatcaaga  cagcaacat  1620
ctgtggtac  gtgggatcc  gaagagcag  ctgcctgga  atccagtgt  ggtcatgtc  1680
gtactgcac  catactatt  gcctaggat  acagactcc  tctgtggta  tgaggggtc  1740
tggaaacat  ttcttttta  gttggtgtc  catttgaat  catatatcc  cttttaata  1800
aagatgatg  aaccgcaaa  aaaaaaaaaa  1830



<210> 8977
<211> 291
<212> PRT
<213> Rattus norvegicus
<308> AAD00504
<400> 8977

Met Glu Arg Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala 
  1               5                  10                  15
Ser Thr Ile Ala Tyr Leu Thr Leu Arg Ala Ser Tyr Ser Leu Phe Arg 
             20                  25                  30
Ala Phe Gln Val Trp Cys Val Gly Asn Gln Ala Phe Val Gly Pro Arg 
         35                  40                  45
Leu Gly Glu Trp Ala Val Val Thr Gly Gly Thr Asp Gly Ile Gly Lys 
     50                  55                  60
Ser Tyr Ala Glu Glu Leu Ala Lys Arg Gly Met Lys Ile Val Leu Ile 
 65                  70                  75                  80
Ser Arg Ser Gln Asp Lys Leu Lys Glu Val Ser Asn Asn Ile Lys Glu 
                 85                  90                  95
Lys Phe Asn Val Glu Thr Arg Thr Ile Ala Val Asp Phe Ser Leu Asp 
             100                105                110
Asp Ile Tyr Asp Lys Ile Lys Thr Gly Leu Ser Gly Leu Glu Ile Gly 
         115                120                125
Val Leu Val Asn Asn Val Gly Met Ser Tyr Glu Tyr Pro Glu Tyr Phe 
     130                135                140
Leu Glu Ile Pro Asp Leu Asp Asn Thr Ile Lys Lys Leu Ile Asn Ile 
 145                150                155                160
Asn Val Leu Ser Ile Cys Lys Val Thr Arg Leu Val Leu Pro Gly Met 
                 165                170                175
Val Glu Arg Ser Lys Gly Val Ile Leu Asn Ile Ser Ser Ala Ser Gly 
             180                185                190
Met Leu Pro Val Pro Leu Leu Thr Val Tyr Ser Ala Thr Lys Ala Phe 
         195                200                205
Val Asp Phe Phe Ser Gln Cys Leu His Glu Glu Tyr Lys Ser Lys Gly 
     210                215                220
Ile Phe Val Gln Ser Val Leu Pro Phe Phe Val Ser Thr Lys Leu Ala 
 225                230                235                240
Lys Ile Arg Lys Pro Thr Leu Asp Lys Pro Ser Ala Glu Thr Phe Val 
                 245                250                255
Lys Ser Ala Ile Lys Thr Val Gly Leu Gln Thr Arg Thr Thr Gly Ile 
             260                265                270
Cys Asp Pro Arg His His Gly Leu Asn Lys Leu Asn Leu Ala Pro Leu 
         275                280                285
Asp Leu Phe 
     290



<210> 8978
<211> 2393
<212> DNA
<213> Homo sapiens
<308> NM_016142
<400> 8978

ggccggcgc  tcctcctgg  ttcattcac  cgctctttt  attcacgaa  gtagtgagg  60
ctagtggaa  gccatggag  gcgctctcc  cgccgccgg  ttcctgtac  gggtcggcg  120
gggcaccgt  gcctaccta  ccctgcgta  ttcgtactc  ctcttcacg  ccctccggg  180
ctggggagt  gggaatgag  cgggggtcg  cccggggct  ggagagtgg  cagttgtca  240
aggtagtac  gatggaatt  gaaaatcat  tgcagaaga  ttagcaaag  atggaatga  300
ggttgtcct  atcagcaga  caaaggata  acttgacca  gtttccagt  aaataaaag  360
aaaattcaa  gtggagaca  gaaccattg  tgttgactt  gcatcagaa  atatttatg  420
taaaattaa  acaggcttg  ctggtcttg  aatcggcat  ttagtgaac  acgtgggaa  480
gtcgtatga  tatcctgaa  actttttgg  tgttcctga  ttggacaat  tgatcaaga  540
aatgataaa  attaatatt  tttctgttt  taagatgac  caattggta  tgcctggca  600
ggtggaaag  tccaaaggg  ctattctga  catttcatc  ggcagtggc  tgctccctg  660
cccactctt  accatctat  ctgcaacca  gacttttgt  gatttcttc  ctcagtgcc  720
ccatgagga  tataggagc  agggcgtct  tgtgcagag  gtcctgcca  acttcgtag  780
tacaaaact  gctaaaatc  ggaagccaa  tttggataa  ccctctccg  agacgtttg  840
gaagtctgc  attaaaaca  tcggcctgc  atcccgaac  aatggatac  tgatccatg  900
tcttatggg  tcgataatc  caaacctgc  ttcttggat  tatttgaaa  tagtcatga  960
tatgaacaa  tctacacgg  ctcactatc  gaagaaaac  aagaagaac  aagcatgat  1020
actgcattg  aacttggcc  gatgctcca  catatgcac  ttcactgca  agcacccta  1080
tggttttga  aatctgacc  tgtcatttc  atagttatt  acatgacta  atattatct  1140
aattaagag  aaaatagaa  ttgctttta  gggtttctg  catatattc  ggatactat  1200
cgaggtaat  ttgaagttt  atataaatg  tcatatcaa  tgaatatag  actaatatt  1260
tcgggaaca  ctaatagaa  ggaatacta  tatagcaaa  cacagaatg  tagactcaa  1320
cataaaact  ggcagtttt  tctgcttca  aatgccatt  atcattatt  ctgtatttt  1380
tctgaaact  attataaaa  ccaatgtcc  gctactctt  tgtttttga  acttgaaga  1440
atggagatc  atttgattt  tttataagc  gacacactg  aatttacaa  gatctcttt  1500
cggttttat  aaattatct  ccagtttgt  catttatat  gaattgttc  ttatcaagg  1560
tagctaatg  catgaaaat  attgtgaaa  atggaatta  ttctgacac  tgaagccca  1620
taaactatg  tttcctata  tgcatattt  ttctcagtt  aaatgtatg  aaatatcga  1680
gctatatgg  atgatttat  aagataaat  ggccaaagt  tacattgag  ctggcagcc  1740
tctatggta  cactgaaac  ctgacccag  aaagtggct  gcttggaca  ccagctgcc  1800
ttgtttctg  attaaacca  tattgatca  acatatgac  caggctagt  ctataaaag  1860
aatgacttc  tagaaatgg  attataatt  ttaagttga  actctacag  tagctattg  1920
tataattag  tttaataaa  catgctgca  ccatggtat  caacaaaaa  acatttctt  1980
ggtgattga  attaaggcc  tatttacaa  gacttaata  aagactgac  tttatcctg  2040
ttcataact  gtatggaga  ctcaccaag  aagaattca  tactgtgaa  tatgcagca  2100
gaagattgg  ctttaccta  gctgtgttt  ctaagctct  agttttcag  accagtaga  2160
ttgtattaa  agaaaaaaa  atggggcct  agcttctgg  ttttaattt  gccagctaa  2220
gacataaaa  aaaaataaa  aaacaaaaa  aaatagcca  ctgctatca  catcattat  2280
taaaagaaa  tatatttta  cccctaaaa  taggaagaa  gtaatctca  aataaaggt  2340
gtcatttaa  ttgaataaa  atatagctt  atgaaaaac  caaaaaaaa  aaa  2393



<210> 8979
<211> 312
<212> PRT
<213> Homo sapiens
<308> NP_057226
<400> 8979

Met Glu Ser Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala 
  1               5                  10                  15
Gly Thr Val Ala Tyr Leu Ala Leu Arg Ile Ser Tyr Ser Leu Phe Thr 
             20                  25                  30
Ala Leu Arg Val Trp Gly Val Gly Asn Glu Ala Gly Val Gly Pro Gly 
         35                  40                  45
Leu Gly Glu Trp Ala Val Val Thr Gly Ser Thr Asp Gly Ile Gly Lys 
     50                  55                  60
Ser Tyr Ala Glu Glu Leu Ala Lys His Gly Met Lys Val Val Leu Ile 
 65                  70                  75                  80
Ser Arg Ser Lys Asp Lys Leu Asp Gln Val Ser Ser Glu Ile Lys Glu 
                 85                  90                  95
Lys Phe Lys Val Glu Thr Arg Thr Ile Ala Val Asp Phe Ala Ser Glu 
             100                105                110
Asp Ile Tyr Asp Lys Ile Lys Thr Gly Leu Ala Gly Leu Glu Ile Gly 
         115                120                125
Ile Leu Val Asn Asn Val Gly Met Ser Tyr Glu Tyr Pro Glu Tyr Phe 
     130                135                140
Leu Asp Val Pro Asp Leu Asp Asn Val Ile Lys Lys Met Ile Asn Ile 
 145                150                155                160
Asn Ile Leu Ser Val Cys Lys Met Thr Gln Leu Val Leu Pro Gly Met 
                 165                170                175
Val Glu Arg Ser Lys Gly Ala Ile Leu Asn Ile Ser Ser Gly Ser Gly 
             180                185                190
Met Leu Pro Val Pro Leu Leu Thr Ile Tyr Ser Ala Thr Lys Thr Phe 
         195                200                205
Val Asp Phe Phe Ser Gln Cys Leu His Glu Glu Tyr Arg Ser Lys Gly 
     210                215                220
Val Phe Val Gln Ser Val Leu Pro Tyr Phe Val Ala Thr Lys Leu Ala 
 225                230                235                240
Lys Ile Arg Lys Pro Thr Leu Asp Lys Pro Ser Pro Glu Thr Phe Val 
                 245                250                255
Lys Ser Ala Ile Lys Thr Val Gly Leu Gln Ser Arg Thr Asn Gly Tyr 
             260                265                270
Leu Ile His Ala Leu Met Gly Ser Ile Ile Ser Asn Leu Pro Ser Trp 
         275                280                285
Ile Tyr Leu Lys Ile Val Met Asn Met Asn Lys Ser Thr Arg Ala His 
     290                295                300
Tyr Leu Lys Lys Thr Lys Lys Asn 
 305                310



<210> 8980
<211> 1830
<212> DNA
<213> Rattus norvegicus
<308> U81186
<400> 8980

tggcgagtt  tggagcgcg  tctcccggc  gccggcttc  tatactggg  gggcgcgag  60
accattgct  acctgaccc  gcgagcctc  tactcgctc  tcagggcct  ccaggtgtg  120
tgcgtgggc  accaggcct  tgtcggccc  cggctcgga  aatgggcag  tgttacagg  180
ggcactgat  gaattggaa  atcatatgc  gaagagtta  caaagcgtg  aatgaagat  240
gtcttgata  gcagatccc  ggataaact  aaggaagtt  ccaacaaca  caaagaaaa  300
ttcaacgtt  aaacaagga  cattgctgt  gacttttca  tggatgata  ttatgataa  360
attaagaca  gcctgtctg  tcttgaaat  ggcgtttta  tgaacaacg  gggcatgtc  420
tacgagtat  cagaatact  tttggaaat  cctgacttg  acaacacca  caagaaact  480
ataaatatt  atgtgcttt  catttgcaa  gtgacacgc  tggtgctgc  tggcatggt  540
gagagatct  aaggggtga  tctcaacat  tcctctgcc  gtggcatgc  cccggttcc  600
ctgttgaca  tctactctg  aaccaaggc  tttgtagat  tcttctctc  gtgcctcca  660
gaggagtat  agagcaagg  catctttgt  cagagtgtc  tgccattct  tgtatctac  720
aaactggca  aaatacgga  gccgacttt  gataagccc  ctgcagaga  atttgtgaa  780
tctgcaatt  aaacagtag  tctgcagac  cgaaccact  ggatatgtg  tccacgcca  840
catgggctc  ataaactca  tcttgcccc  ttggattta  tttaaaacg  tcatgggtt  900
caacaagtc  ttgcggaat  gctatctga  gaaaaccaa  aagaactaa  ttctgctgg  960
tcatcgagc  ccttggcca  acgcttgac  tgtgcttgc  tactgggcc  ctgcctgtc  1020
ccagagtct  tactgtcat  tcagtaatt  ctaacatgg  atagctggc  gaaagcaaa  1080
tccttttag  ggttcctaa  atatattct  gatacaacc  ggagtaatt  gaagtttaa  1140
ataaatgtt  ttggcaaat  tatgtatac  actttgaca  aaaggaaca  atcccagaa  1200
gacagacgt  gcacccatc  ggcccagaa  gccaatgat  acctaatat  tggtctgga  1260
cctactata  agtgtaata  ctagctact  ttttatttt  aacattaaa  ggaatgggg  1320
ttagttgat  tttttttta  gggcagata  aatgcagtt  acattgatt  ctgtaaggt  1380
ttctaaagg  atgttccag  ttatgtgtt  ctatggaac  ggtcttctt  aaagtagct  1440
agaaagaca  aaagagaat  gaaacacgg  gttctttct  acacagaag  ccacaaaat  1500
ttattcttg  aacacacat  atgtctgct  tgttccatg  atgtaaata  tgaatgcta  1560
atagtgtga  tgaaatgta  aggtaagtg  gcccaagtg  acatcaaga  cagcaacat  1620
ctgtggtac  gtgggatcc  gaagagcag  ctgcctgga  atccagtgt  ggtcatgtc  1680
gtactgcac  catactatt  gcctaggat  acagactcc  tctgtggta  tgaggggtc  1740
tggaaacat  ttcttttta  gttggtgtc  catttgaat  catatatcc  cttttaata  1800
aagatgatg  aaccgcaaa  aaaaaaaaaa  1830



<210> 8981
<211> 291
<212> PRT
<213> Rattus norvegicus
<308> AAD00504
<400> 8981

Met Glu Arg Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala 
  1               5                  10                  15
Ser Thr Ile Ala Tyr Leu Thr Leu Arg Ala Ser Tyr Ser Leu Phe Arg 
             20                  25                  30
Ala Phe Gln Val Trp Cys Val Gly Asn Gln Ala Phe Val Gly Pro Arg 
         35                  40                  45
Leu Gly Glu Trp Ala Val Val Thr Gly Gly Thr Asp Gly Ile Gly Lys 
     50                  55                  60
Ser Tyr Ala Glu Glu Leu Ala Lys Arg Gly Met Lys Ile Val Leu Ile 
 65                  70                  75                  80
Ser Arg Ser Gln Asp Lys Leu Lys Glu Val Ser Asn Asn Ile Lys Glu 
                 85                  90                  95
Lys Phe Asn Val Glu Thr Arg Thr Ile Ala Val Asp Phe Ser Leu Asp 
             100                105                110
Asp Ile Tyr Asp Lys Ile Lys Thr Gly Leu Ser Gly Leu Glu Ile Gly 
         115                120                125
Val Leu Val Asn Asn Val Gly Met Ser Tyr Glu Tyr Pro Glu Tyr Phe 
     130                135                140
Leu Glu Ile Pro Asp Leu Asp Asn Thr Ile Lys Lys Leu Ile Asn Ile 
 145                150                155                160
Asn Val Leu Ser Ile Cys Lys Val Thr Arg Leu Val Leu Pro Gly Met 
                 165                170                175
Val Glu Arg Ser Lys Gly Val Ile Leu Asn Ile Ser Ser Ala Ser Gly 
             180                185                190
Met Leu Pro Val Pro Leu Leu Thr Val Tyr Ser Ala Thr Lys Ala Phe 
         195                200                205
Val Asp Phe Phe Ser Gln Cys Leu His Glu Glu Tyr Lys Ser Lys Gly 
     210                215                220
Ile Phe Val Gln Ser Val Leu Pro Phe Phe Val Ser Thr Lys Leu Ala 
 225                230                235                240
Lys Ile Arg Lys Pro Thr Leu Asp Lys Pro Ser Ala Glu Thr Phe Val 
                 245                250                255
Lys Ser Ala Ile Lys Thr Val Gly Leu Gln Thr Arg Thr Thr Gly Ile 
             260                265                270
Cys Asp Pro Arg His His Gly Leu Asn Lys Leu Asn Leu Ala Pro Leu 
         275                280                285
Asp Leu Phe 
     290



<210> 8982
<211> 2393
<212> DNA
<213> Homo sapiens
<308> NM_016142
<400> 8982

ggccggcgc  tcctcctgg  ttcattcac  cgctctttt  attcacgaa  gtagtgagg  60
ctagtggaa  gccatggag  gcgctctcc  cgccgccgg  ttcctgtac  gggtcggcg  120
gggcaccgt  gcctaccta  ccctgcgta  ttcgtactc  ctcttcacg  ccctccggg  180
ctggggagt  gggaatgag  cgggggtcg  cccggggct  ggagagtgg  cagttgtca  240
aggtagtac  gatggaatt  gaaaatcat  tgcagaaga  ttagcaaag  atggaatga  300
ggttgtcct  atcagcaga  caaaggata  acttgacca  gtttccagt  aaataaaag  360
aaaattcaa  gtggagaca  gaaccattg  tgttgactt  gcatcagaa  atatttatg  420
taaaattaa  acaggcttg  ctggtcttg  aatcggcat  ttagtgaac  acgtgggaa  480
gtcgtatga  tatcctgaa  actttttgg  tgttcctga  ttggacaat  tgatcaaga  540
aatgataaa  attaatatt  tttctgttt  taagatgac  caattggta  tgcctggca  600
ggtggaaag  tccaaaggg  ctattctga  catttcatc  ggcagtggc  tgctccctg  660
cccactctt  accatctat  ctgcaacca  gacttttgt  gatttcttc  ctcagtgcc  720
ccatgagga  tataggagc  agggcgtct  tgtgcagag  gtcctgcca  acttcgtag  780
tacaaaact  gctaaaatc  ggaagccaa  tttggataa  ccctctccg  agacgtttg  840
gaagtctgc  attaaaaca  tcggcctgc  atcccgaac  aatggatac  tgatccatg  900
tcttatggg  tcgataatc  caaacctgc  ttcttggat  tatttgaaa  tagtcatga  960
tatgaacaa  tctacacgg  ctcactatc  gaagaaaac  aagaagaac  aagcatgat  1020
actgcattg  aacttggcc  gatgctcca  catatgcac  ttcactgca  agcacccta  1080
tggttttga  aatctgacc  tgtcatttc  atagttatt  acatgacta  atattatct  1140
aattaagag  aaaatagaa  ttgctttta  gggtttctg  catatattc  ggatactat  1200
cgaggtaat  ttgaagttt  atataaatg  tcatatcaa  tgaatatag  actaatatt  1260
tcgggaaca  ctaatagaa  ggaatacta  tatagcaaa  cacagaatg  tagactcaa  1320
cataaaact  ggcagtttt  tctgcttca  aatgccatt  atcattatt  ctgtatttt  1380
tctgaaact  attataaaa  ccaatgtcc  gctactctt  tgtttttga  acttgaaga  1440
atggagatc  atttgattt  tttataagc  gacacactg  aatttacaa  gatctcttt  1500
cggttttat  aaattatct  ccagtttgt  catttatat  gaattgttc  ttatcaagg  1560
tagctaatg  catgaaaat  attgtgaaa  atggaatta  ttctgacac  tgaagccca  1620
taaactatg  tttcctata  tgcatattt  ttctcagtt  aaatgtatg  aaatatcga  1680
gctatatgg  atgatttat  aagataaat  ggccaaagt  tacattgag  ctggcagcc  1740
tctatggta  cactgaaac  ctgacccag  aaagtggct  gcttggaca  ccagctgcc  1800
ttgtttctg  attaaacca  tattgatca  acatatgac  caggctagt  ctataaaag  1860
aatgacttc  tagaaatgg  attataatt  ttaagttga  actctacag  tagctattg  1920
tataattag  tttaataaa  catgctgca  ccatggtat  caacaaaaa  acatttctt  1980
ggtgattga  attaaggcc  tatttacaa  gacttaata  aagactgac  tttatcctg  2040
ttcataact  gtatggaga  ctcaccaag  aagaattca  tactgtgaa  tatgcagca  2100
gaagattgg  ctttaccta  gctgtgttt  ctaagctct  agttttcag  accagtaga  2160
ttgtattaa  agaaaaaaa  atggggcct  agcttctgg  ttttaattt  gccagctaa  2220
gacataaaa  aaaaataaa  aaacaaaaa  aaatagcca  ctgctatca  catcattat  2280
taaaagaaa  tatatttta  cccctaaaa  taggaagaa  gtaatctca  aataaaggt  2340
gtcatttaa  ttgaataaa  atatagctt  atgaaaaac  caaaaaaaa  aaa  2393



<210> 8983
<211> 312
<212> PRT
<213> Homo sapiens
<308> NP_057226
<400> 8983

Met Glu Ser Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala 
  1               5                  10                  15
Gly Thr Val Ala Tyr Leu Ala Leu Arg Ile Ser Tyr Ser Leu Phe Thr 
             20                  25                  30
Ala Leu Arg Val Trp Gly Val Gly Asn Glu Ala Gly Val Gly Pro Gly 
         35                  40                  45
Leu Gly Glu Trp Ala Val Val Thr Gly Ser Thr Asp Gly Ile Gly Lys 
     50                  55                  60
Ser Tyr Ala Glu Glu Leu Ala Lys His Gly Met Lys Val Val Leu Ile 
 65                  70                  75                  80
Ser Arg Ser Lys Asp Lys Leu Asp Gln Val Ser Ser Glu Ile Lys Glu 
                 85                  90                  95
Lys Phe Lys Val Glu Thr Arg Thr Ile Ala Val Asp Phe Ala Ser Glu 
             100                105                110
Asp Ile Tyr Asp Lys Ile Lys Thr Gly Leu Ala Gly Leu Glu Ile Gly 
         115                120                125
Ile Leu Val Asn Asn Val Gly Met Ser Tyr Glu Tyr Pro Glu Tyr Phe 
     130                135                140
Leu Asp Val Pro Asp Leu Asp Asn Val Ile Lys Lys Met Ile Asn Ile 
 145                150                155                160
Asn Ile Leu Ser Val Cys Lys Met Thr Gln Leu Val Leu Pro Gly Met 
                 165                170                175
Val Glu Arg Ser Lys Gly Ala Ile Leu Asn Ile Ser Ser Gly Ser Gly 
             180                185                190
Met Leu Pro Val Pro Leu Leu Thr Ile Tyr Ser Ala Thr Lys Thr Phe 
         195                200                205
Val Asp Phe Phe Ser Gln Cys Leu His Glu Glu Tyr Arg Ser Lys Gly 
     210                215                220
Val Phe Val Gln Ser Val Leu Pro Tyr Phe Val Ala Thr Lys Leu Ala 
 225                230                235                240
Lys Ile Arg Lys Pro Thr Leu Asp Lys Pro Ser Pro Glu Thr Phe Val 
                 245                250                255
Lys Ser Ala Ile Lys Thr Val Gly Leu Gln Ser Arg Thr Asn Gly Tyr 
             260                265                270
Leu Ile His Ala Leu Met Gly Ser Ile Ile Ser Asn Leu Pro Ser Trp 
         275                280                285
Ile Tyr Leu Lys Ile Val Met Asn Met Asn Lys Ser Thr Arg Ala His 
     290                295                300
Tyr Leu Lys Lys Thr Lys Lys Asn 
 305                310



<210> 8984
<211> 1830
<212> DNA
<213> Rattus norvegicus
<308> U81186
<400> 8984

tggcgagtt  tggagcgcg  tctcccggc  gccggcttc  tatactggg  gggcgcgag  60
accattgct  acctgaccc  gcgagcctc  tactcgctc  tcagggcct  ccaggtgtg  120
tgcgtgggc  accaggcct  tgtcggccc  cggctcgga  aatgggcag  tgttacagg  180
ggcactgat  gaattggaa  atcatatgc  gaagagtta  caaagcgtg  aatgaagat  240
gtcttgata  gcagatccc  ggataaact  aaggaagtt  ccaacaaca  caaagaaaa  300
ttcaacgtt  aaacaagga  cattgctgt  gacttttca  tggatgata  ttatgataa  360
attaagaca  gcctgtctg  tcttgaaat  ggcgtttta  tgaacaacg  gggcatgtc  420
tacgagtat  cagaatact  tttggaaat  cctgacttg  acaacacca  caagaaact  480
ataaatatt  atgtgcttt  catttgcaa  gtgacacgc  tggtgctgc  tggcatggt  540
gagagatct  aaggggtga  tctcaacat  tcctctgcc  gtggcatgc  cccggttcc  600
ctgttgaca  tctactctg  aaccaaggc  tttgtagat  tcttctctc  gtgcctcca  660
gaggagtat  agagcaagg  catctttgt  cagagtgtc  tgccattct  tgtatctac  720
aaactggca  aaatacgga  gccgacttt  gataagccc  ctgcagaga  atttgtgaa  780
tctgcaatt  aaacagtag  tctgcagac  cgaaccact  ggatatgtg  tccacgcca  840
catgggctc  ataaactca  tcttgcccc  ttggattta  tttaaaacg  tcatgggtt  900
caacaagtc  ttgcggaat  gctatctga  gaaaaccaa  aagaactaa  ttctgctgg  960
tcatcgagc  ccttggcca  acgcttgac  tgtgcttgc  tactgggcc  ctgcctgtc  1020
ccagagtct  tactgtcat  tcagtaatt  ctaacatgg  atagctggc  gaaagcaaa  1080
tccttttag  ggttcctaa  atatattct  gatacaacc  ggagtaatt  gaagtttaa  1140
ataaatgtt  ttggcaaat  tatgtatac  actttgaca  aaaggaaca  atcccagaa  1200
gacagacgt  gcacccatc  ggcccagaa  gccaatgat  acctaatat  tggtctgga  1260
cctactata  agtgtaata  ctagctact  ttttatttt  aacattaaa  ggaatgggg  1320
ttagttgat  tttttttta  gggcagata  aatgcagtt  acattgatt  ctgtaaggt  1380
ttctaaagg  atgttccag  ttatgtgtt  ctatggaac  ggtcttctt  aaagtagct  1440
agaaagaca  aaagagaat  gaaacacgg  gttctttct  acacagaag  ccacaaaat  1500
ttattcttg  aacacacat  atgtctgct  tgttccatg  atgtaaata  tgaatgcta  1560
atagtgtga  tgaaatgta  aggtaagtg  gcccaagtg  acatcaaga  cagcaacat  1620
ctgtggtac  gtgggatcc  gaagagcag  ctgcctgga  atccagtgt  ggtcatgtc  1680
gtactgcac  catactatt  gcctaggat  acagactcc  tctgtggta  tgaggggtc  1740
tggaaacat  ttcttttta  gttggtgtc  catttgaat  catatatcc  cttttaata  1800
aagatgatg  aaccgcaaa  aaaaaaaaaa  1830



<210> 8985
<211> 291
<212> PRT
<213> Rattus norvegicus
<308> AAD00504
<400> 8985

Met Glu Arg Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala 
  1               5                  10                  15
Ser Thr Ile Ala Tyr Leu Thr Leu Arg Ala Ser Tyr Ser Leu Phe Arg 
             20                  25                  30
Ala Phe Gln Val Trp Cys Val Gly Asn Gln Ala Phe Val Gly Pro Arg 
         35                  40                  45
Leu Gly Glu Trp Ala Val Val Thr Gly Gly Thr Asp Gly Ile Gly Lys 
     50                  55                  60
Ser Tyr Ala Glu Glu Leu Ala Lys Arg Gly Met Lys Ile Val Leu Ile 
 65                  70                  75                  80
Ser Arg Ser Gln Asp Lys Leu Lys Glu Val Ser Asn Asn Ile Lys Glu 
                 85                  90                  95
Lys Phe Asn Val Glu Thr Arg Thr Ile Ala Val Asp Phe Ser Leu Asp 
             100                105                110
Asp Ile Tyr Asp Lys Ile Lys Thr Gly Leu Ser Gly Leu Glu Ile Gly 
         115                120                125
Val Leu Val Asn Asn Val Gly Met Ser Tyr Glu Tyr Pro Glu Tyr Phe 
     130                135                140
Leu Glu Ile Pro Asp Leu Asp Asn Thr Ile Lys Lys Leu Ile Asn Ile 
 145                150                155                160
Asn Val Leu Ser Ile Cys Lys Val Thr Arg Leu Val Leu Pro Gly Met 
                 165                170                175
Val Glu Arg Ser Lys Gly Val Ile Leu Asn Ile Ser Ser Ala Ser Gly 
             180                185                190
Met Leu Pro Val Pro Leu Leu Thr Val Tyr Ser Ala Thr Lys Ala Phe 
         195                200                205
Val Asp Phe Phe Ser Gln Cys Leu His Glu Glu Tyr Lys Ser Lys Gly 
     210                215                220
Ile Phe Val Gln Ser Val Leu Pro Phe Phe Val Ser Thr Lys Leu Ala 
 225                230                235                240
Lys Ile Arg Lys Pro Thr Leu Asp Lys Pro Ser Ala Glu Thr Phe Val 
                 245                250                255
Lys Ser Ala Ile Lys Thr Val Gly Leu Gln Thr Arg Thr Thr Gly Ile 
             260                265                270
Cys Asp Pro Arg His His Gly Leu Asn Lys Leu Asn Leu Ala Pro Leu 
         275                280                285
Asp Leu Phe 
     290



<210> 8986
<211> 2393
<212> DNA
<213> Homo sapiens
<308> NM_016142
<400> 8986

ggccggcgc  tcctcctgg  ttcattcac  cgctctttt  attcacgaa  gtagtgagg  60
ctagtggaa  gccatggag  gcgctctcc  cgccgccgg  ttcctgtac  gggtcggcg  120
gggcaccgt  gcctaccta  ccctgcgta  ttcgtactc  ctcttcacg  ccctccggg  180
ctggggagt  gggaatgag  cgggggtcg  cccggggct  ggagagtgg  cagttgtca  240
aggtagtac  gatggaatt  gaaaatcat  tgcagaaga  ttagcaaag  atggaatga  300
ggttgtcct  atcagcaga  caaaggata  acttgacca  gtttccagt  aaataaaag  360
aaaattcaa  gtggagaca  gaaccattg  tgttgactt  gcatcagaa  atatttatg  420
taaaattaa  acaggcttg  ctggtcttg  aatcggcat  ttagtgaac  acgtgggaa  480
gtcgtatga  tatcctgaa  actttttgg  tgttcctga  ttggacaat  tgatcaaga  540
aatgataaa  attaatatt  tttctgttt  taagatgac  caattggta  tgcctggca  600
ggtggaaag  tccaaaggg  ctattctga  catttcatc  ggcagtggc  tgctccctg  660
cccactctt  accatctat  ctgcaacca  gacttttgt  gatttcttc  ctcagtgcc  720
ccatgagga  tataggagc  agggcgtct  tgtgcagag  gtcctgcca  acttcgtag  780
tacaaaact  gctaaaatc  ggaagccaa  tttggataa  ccctctccg  agacgtttg  840
gaagtctgc  attaaaaca  tcggcctgc  atcccgaac  aatggatac  tgatccatg  900
tcttatggg  tcgataatc  caaacctgc  ttcttggat  tatttgaaa  tagtcatga  960
tatgaacaa  tctacacgg  ctcactatc  gaagaaaac  aagaagaac  aagcatgat  1020
actgcattg  aacttggcc  gatgctcca  catatgcac  ttcactgca  agcacccta  1080
tggttttga  aatctgacc  tgtcatttc  atagttatt  acatgacta  atattatct  1140
aattaagag  aaaatagaa  ttgctttta  gggtttctg  catatattc  ggatactat  1200
cgaggtaat  ttgaagttt  atataaatg  tcatatcaa  tgaatatag  actaatatt  1260
tcgggaaca  ctaatagaa  ggaatacta  tatagcaaa  cacagaatg  tagactcaa  1320
cataaaact  ggcagtttt  tctgcttca  aatgccatt  atcattatt  ctgtatttt  1380
tctgaaact  attataaaa  ccaatgtcc  gctactctt  tgtttttga  acttgaaga  1440
atggagatc  atttgattt  tttataagc  gacacactg  aatttacaa  gatctcttt  1500
cggttttat  aaattatct  ccagtttgt  catttatat  gaattgttc  ttatcaagg  1560
tagctaatg  catgaaaat  attgtgaaa  atggaatta  ttctgacac  tgaagccca  1620
taaactatg  tttcctata  tgcatattt  ttctcagtt  aaatgtatg  aaatatcga  1680
gctatatgg  atgatttat  aagataaat  ggccaaagt  tacattgag  ctggcagcc  1740
tctatggta  cactgaaac  ctgacccag  aaagtggct  gcttggaca  ccagctgcc  1800
ttgtttctg  attaaacca  tattgatca  acatatgac  caggctagt  ctataaaag  1860
aatgacttc  tagaaatgg  attataatt  ttaagttga  actctacag  tagctattg  1920
tataattag  tttaataaa  catgctgca  ccatggtat  caacaaaaa  acatttctt  1980
ggtgattga  attaaggcc  tatttacaa  gacttaata  aagactgac  tttatcctg  2040
ttcataact  gtatggaga  ctcaccaag  aagaattca  tactgtgaa  tatgcagca  2100
gaagattgg  ctttaccta  gctgtgttt  ctaagctct  agttttcag  accagtaga  2160
ttgtattaa  agaaaaaaa  atggggcct  agcttctgg  ttttaattt  gccagctaa  2220
gacataaaa  aaaaataaa  aaacaaaaa  aaatagcca  ctgctatca  catcattat  2280
taaaagaaa  tatatttta  cccctaaaa  taggaagaa  gtaatctca  aataaaggt  2340
gtcatttaa  ttgaataaa  atatagctt  atgaaaaac  caaaaaaaa  aaa  2393



<210> 8987
<211> 312
<212> PRT
<213> Homo sapiens
<308> NP_057226
<400> 8987

Met Glu Ser Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala 
  1               5                  10                  15
Gly Thr Val Ala Tyr Leu Ala Leu Arg Ile Ser Tyr Ser Leu Phe Thr 
             20                  25                  30
Ala Leu Arg Val Trp Gly Val Gly Asn Glu Ala Gly Val Gly Pro Gly 
         35                  40                  45
Leu Gly Glu Trp Ala Val Val Thr Gly Ser Thr Asp Gly Ile Gly Lys 
     50                  55                  60
Ser Tyr Ala Glu Glu Leu Ala Lys His Gly Met Lys Val Val Leu Ile 
 65                  70                  75                  80
Ser Arg Ser Lys Asp Lys Leu Asp Gln Val Ser Ser Glu Ile Lys Glu 
                 85                  90                  95
Lys Phe Lys Val Glu Thr Arg Thr Ile Ala Val Asp Phe Ala Ser Glu 
             100                105                110
Asp Ile Tyr Asp Lys Ile Lys Thr Gly Leu Ala Gly Leu Glu Ile Gly 
         115                120                125
Ile Leu Val Asn Asn Val Gly Met Ser Tyr Glu Tyr Pro Glu Tyr Phe 
     130                135                140
Leu Asp Val Pro Asp Leu Asp Asn Val Ile Lys Lys Met Ile Asn Ile 
 145                150                155                160
Asn Ile Leu Ser Val Cys Lys Met Thr Gln Leu Val Leu Pro Gly Met 
                 165                170                175
Val Glu Arg Ser Lys Gly Ala Ile Leu Asn Ile Ser Ser Gly Ser Gly 
             180                185                190
Met Leu Pro Val Pro Leu Leu Thr Ile Tyr Ser Ala Thr Lys Thr Phe 
         195                200                205
Val Asp Phe Phe Ser Gln Cys Leu His Glu Glu Tyr Arg Ser Lys Gly 
     210                215                220
Val Phe Val Gln Ser Val Leu Pro Tyr Phe Val Ala Thr Lys Leu Ala 
 225                230                235                240
Lys Ile Arg Lys Pro Thr Leu Asp Lys Pro Ser Pro Glu Thr Phe Val 
                 245                250                255
Lys Ser Ala Ile Lys Thr Val Gly Leu Gln Ser Arg Thr Asn Gly Tyr 
             260                265                270
Leu Ile His Ala Leu Met Gly Ser Ile Ile Ser Asn Leu Pro Ser Trp 
         275                280                285
Ile Tyr Leu Lys Ile Val Met Asn Met Asn Lys Ser Thr Arg Ala His 
     290                295                300
Tyr Leu Lys Lys Thr Lys Lys Asn 
 305                310



<210> 8988
<211> 3622
<212> DNA
<213> Rattus norvegicus
<308> U82623
<400> 8988

cagcgtgag  gcgaggcgg  ggcggcggc  gcagcggag  ggacggtcg  tcggcggca  60
gcactggtg  aatggatag  taacagaag  ccacttccc  tcctcctca  ggcttcagc  120
tgactgagt  cttcctgcc  cccaccagc  gccctagtg  acaccgcag  gccgagcac  180
gcagcgggc  gacccggac  cccagctcc  aggagatca  ccctacaaa  tttcctgga  240
tgtaccgga  gggtgagcc  tcacctccc  atgacatcc  ccacgagcc  cctgatatc  300
tgtcagatg  tgagaaaga  catggaaag  aaaaaggaa  atttaagaa  aaggagaaa  360
ggactgaag  ctacgctgc  ttccaggaa  acagctctg  agatgaggc  gaaagtcct  420
ccaagatga  gaggtccaa  ggcatccat  tgttcaaaa  gcccagctt  tctaaaaag  480
aggaaaagg  ttttaaaat  aaagaaaag  ccaaagaag  aaagcacaa  gaagaaaag  540
ataaagagg  aaagcataa  gaaaagaaa  gtaaagact  gacggccgc  gatgttgtt  600
aacagtgga  ggaaaagaa  aaaaagaag  agccaactc  ggagccaga  gtgcctcag  660
cggacgccc  gagtctcag  cccattttc  gcgctccct  ggctgacgc  gtagagagg  720
ccatgatgt  cgacggcat  cggctgcca  ctgtcttcc  ggagtgcgt  gactacatg  780
agaagcacg  catgaaatg  gaaggcatc  accgagtgt  aggaatcaa  tcaaaggta  840
atgagctga  agcagccta  gaccgagag  agtctccaa  cttggaaga  tatgaacct  900
acactgtag  cagcttgct  aagcagtat  tgcgagacc  tcccgagaa  ttgcttacc  960
aagagctta  gccccgatt  gaagaggct  gtgggagga  cacagaggt  gagaaagtg  1020
aggagttcc  gcgcttgct  agggaactg  cggagtaca  ccatcttct  ctctcctgg  1080
tcattgtgc  catggacca  gtcatcgcg  aggagctgg  aaccaagat  aacatccag  1140
acatctcca  agtgctgag  ccaaccgtc  agatcagca  ccgggtcct  tatgtgctt  1200
tcacacacg  gcaagagct  tttggcacc  tggtcctga  gcaagtaac  agacctctg  1260
gttggtcca  catggccac  atgcctaca  tgccagaga  ccaagcagg  atcaaggaa  1320
aaatcagga  acaggagtt  cttttgaac  gtttacatc  agatctgca  ggcgggata  1380
aggacttgt  taaagaaga  agattatgg  aagtacaga  gattctgac  gccctcaag  1440
gaaagctga  ggaagctaa  agacaagag  gtgagacca  gattgcaca  gagatagcc  1500
gcctttcga  ggaggatgt  tccaaagaa  aaacgaacg  aaacgagga  gtcataaat  1560
tcctccttg  ccaggagaa  gagatcctg  ctgagcagg  ggagctcct  gccatggag  1620
agtttctgc  tcgtcagat  gcctcggag  aagaagaga  tgaccccct  cgagctgag  1680
ttgcggaga  ccagagtcg  cagcatggc  gcagcgaga  agaggagta  tcctctgac  1740
gcgagagcg  gagcgagga  gaggaggag  tgcagatca  tctggaaga  ttacagagg  1800
agaatgaag  gttagaaat  aagaacaat  acttgaacc  ggcagtcca  gaagagcgg  1860
aggccatcg  tgagctccg  gtgcagctc  ggctgctcc  gatgctgcg  gccaagtct  1920
agcagcagc  ccaggagga  gaggagccc  agaggcgag  gggcacagg  ccactaccc  1980
gtgaaggtg  cctcgaggt  agagcagcc  aggagcagg  gaagcctcg  ccagcaaag  2040
ccggaagga  acgcccatc  gaactgccc  ggccctgtg  atcgtactg  aagcgagag  2100
ccgctgcct  tcctgccag  cagcgttct  tgaaggctc  cagagacgc  cgctcttgc  2160
cacgtctga  tccgtgtca  gctcaggtc  tgggagagt  aaggggtgg  cactcgggg  2220
tggggggct  gcagggaac  caggtattt  cagatagtg  cagcttatt  gaaaattaa  2280
tttctttgt  aaaaataac  attttaacc  ttgagtggc  tctttttaa  ccaaaaaac  2340
ttttgcttt  ttttgttgt  gtttaaatc  cagcagaat  aggatctct  tcttatcaa  2400
gggtgggaa  caaaccagg  cacttctgc  cctgccttg  ggacgctcg  ggtctcacc  2460
gccctgcag  gtccctggc  actcttgct  gtgccttcc  caccttttg  tgcagattg  2520
tcagtgggg  gctgcctca  attctctga  tggccaaaa  ggctctcgc  ggggttccc  2580
gtacctgcc  tgtgtgtac  actttgctt  tccagctcc  ggtctgtca  tgtgagtca  2640
gacggccca  tttggttgc  gacggaggt  accatgcag  ctgccacca  cctgggcag  2700
gcaggccac  cactcactg  cagggagca  caagggcct  ttctcagag  tggtcagag  2760
tgaccacct  gaccctgag  ttgcacagg  cacttctca  accagggtc  ttttccaca  2820
tgaccttcc  ggaaagtca  cttccacag  gacttcagt  gctagcttg  gctgggata  2880
ccacacctc  gccaggata  gccatgtag  tgctgtcat  cacaacttt  acctgtcca  2940
gtcatctca  ggggctgct  aaggactct  acagaactg  gcggaagga  ggaaagcgt  3000
actgtaatt  accccccct  gtgtttgcc  ctaacctgg  cgactgctc  cagcggtct  3060
ggaggccgg  ctcttaggc  accggattt  actgtcaga  gagtggccc  cagggaggt  3120
cccctgtgg  tctgaagac  aatcccaca  tctaaagtg  gcgacaaac  cacaggagg  3180
ctccggtct  ctcctagtt  gtatttatt  cagcacctg  tggtgcgat  tttcgttag  3240
ctctaccta  tgcactgtt  tgacttgtt  gccattatt  gatttttgt  cggaaaaaa  3300
agctttgtt  tagaaatca  catactatt  ttttaaatc  ggagagaag  tattatgga  3360
actggaaac  tggtcaggt  tcaaatgta  atgtataaa  gccttgctg  acccgtcag  3420
tgtgcaaca  tcattctat  tttgctggc  atattgagg  attcttttt  tttgtgtaa  3480
ctctaattt  tatcaaggt  tcatgggtt  ttaaaattt  attacaaat  tctcaatgt  3540
ggttaacta  tttttgcca  gaccattat  gattaagga  ataaactca  cagccattt  3600
agaaaaaaa  aaaaaaaaa  aa  3622



<210> 8989
<211> 693
<212> PRT
<213> Rattus norvegicus
<308> AAB91537
<400> 8989

Met Thr Glu Cys Phe Leu Pro Pro Thr Ser Ser Pro Ser Glu His Arg 
  1               5                  10                  15
Arg Ala Glu His Gly Ser Gly Leu Thr Arg Thr Pro Ser Ser Glu Glu 
             20                  25                  30
Ile Ser Pro Thr Lys Phe Pro Gly Leu Tyr Arg Thr Gly Glu Pro Ser 
         35                  40                  45
Pro Pro His Asp Ile Leu His Glu Pro Pro Asp Ile Val Ser Asp Asp 
     50                  55                  60
Glu Lys Asp His Gly Lys Lys Lys Gly Lys Phe Lys Lys Lys Glu Lys 
 65                  70                  75                  80
Arg Thr Glu Gly Tyr Ala Ala Phe Gln Glu Asp Ser Ser Gly Asp Glu 
                 85                  90                  95
Ala Glu Ser Pro Ser Lys Met Lys Arg Ser Lys Gly Ile His Val Phe 
             100                105                110
Lys Lys Pro Ser Phe Ser Lys Lys Lys Glu Lys Asp Phe Lys Ile Lys 
         115                120                125
Glu Lys Pro Lys Glu Glu Lys His Lys Glu Glu Lys His Lys Glu Glu 
     130                135                140
Lys His Lys Glu Lys Lys Cys Lys Asp Leu Thr Ala Ala Asp Val Val 
 145                150                155                160
Lys Gln Trp Lys Glu Lys Lys Lys Lys Lys Lys Pro Thr Gln Glu Pro 
                 165                170                175
Glu Val Pro Gln Thr Asp Ala Pro Ser Leu Arg Pro Ile Phe Gly Ala 
             180                185                190
Pro Leu Ala Asp Ala Val Glu Arg Thr Met Met Tyr Asp Gly Ile Arg 
         195                200                205
Leu Pro Ala Val Phe Arg Glu Cys Val Asp Tyr Met Glu Lys His Gly 
     210                215                220
Met Lys Cys Glu Gly Ile Tyr Arg Val Ser Gly Ile Lys Ser Lys Val 
 225                230                235                240
Asp Glu Leu Lys Ala Ala Tyr Asp Arg Glu Glu Ser Pro Asn Leu Glu 
                 245                250                255
Glu Tyr Glu Pro Asn Thr Val Ala Ser Leu Leu Lys Gln Tyr Leu Arg 
             260                265                270
Asp Leu Pro Glu Asn Leu Leu Thr Lys Glu Leu Met Pro Arg Phe Glu 
         275                280                285
Glu Ala Cys Gly Arg Thr Thr Glu Val Glu Lys Val Gln Glu Phe Gln 
     290                295                300
Arg Leu Leu Arg Glu Leu Pro Glu Tyr Asn His Leu Leu Leu Ser Trp 
 305                310                315                320
Leu Ile Val His Met Asp His Val Ile Ala Lys Glu Leu Glu Thr Lys 
                 325                330                335
Met Asn Ile Gln Asn Ile Ser Ile Val Leu Ser Pro Thr Val Gln Ile 
             340                345                350
Ser Asn Arg Val Leu Tyr Val Leu Phe Thr His Val Gln Glu Leu Phe 
         355                360                365
Gly Thr Val Val Leu Lys Gln Val Thr Arg Pro Leu Arg Trp Ser Asn 
     370                375                380
Met Ala Thr Met Pro Thr Leu Pro Glu Thr Gln Ala Gly Ile Lys Glu 
 385                390                395                400
Glu Ile Arg Arg Gln Glu Phe Leu Leu Asn Cys Leu His Arg Asp Leu 
                 405                410                415
Gln Gly Gly Ile Lys Asp Leu Ser Lys Glu Glu Arg Leu Trp Glu Val 
             420                425                430
Gln Arg Ile Leu Thr Ala Leu Lys Arg Lys Leu Arg Glu Ala Lys Arg 
         435                440                445
Gln Glu Cys Glu Thr Lys Ile Ala Gln Glu Ile Ala Ser Leu Ser Lys 
     450                455                460
Glu Asp Val Ser Lys Glu Glu Thr Asn Glu Asn Glu Glu Val Ile Asn 
 465                470                475                480
Ile Leu Leu Ala Gln Glu Asn Glu Ile Leu Thr Glu Gln Glu Glu Leu 
                 485                490                495
Leu Ala Met Glu Gln Phe Leu Arg Arg Gln Ile Ala Ser Glu Lys Glu 
             500                505                510
Glu Ile Asp Pro Leu Arg Ala Glu Ile Ala Glu Ile Gln Ser Arg Gln 
         515                520                525
His Gly Arg Ser Glu Thr Glu Glu Tyr Ser Ser Asp Ser Glu Ser Glu 
     530                535                540
Ser Glu Asp Glu Glu Glu Leu Gln Ile Ile Leu Glu Asp Leu Gln Arg 
 545                550                555                560
Gln Asn Glu Glu Leu Glu Ile Lys Asn Asn His Leu Asn Gln Ala Val 
                 565                570                575
His Glu Glu Arg Glu Ala Ile Val Glu Leu Arg Val Gln Leu Arg Leu 
             580                585                590
Leu Gln Met Leu Arg Ala Lys Ser Glu Gln Gln Leu Gln Glu Glu Glu 
         595                600                605
Glu Pro Glu Arg Arg Gly Gly Thr Gly Pro Leu Pro Cys Glu Gly Val 
     610                615                620
Leu Glu Val Arg Ala Ala Lys Glu Gln Ala Lys Pro Arg Pro Ala Lys 
 625                630                635                640
Thr Gly Arg Arg Arg Pro Ser Glu Leu Pro Arg Pro Cys Ala Ser Tyr 
                 645                650                655
Cys Lys Arg Glu Ser Ala Ala Cys Pro Ala Arg Gln Arg Ser Val Lys 
             660                665                670
Ala Leu Arg Asp Ala Arg Ser Cys Thr Arg Leu Thr Pro Cys Gln Ala 
         675                680                685
Gln Val Leu Gly Glu 
     690



<210> 8990
<211> 217
<212> DNA
<213> Homo sapiens
<308> AA029488
<400> 8990

aaaccccac  cgagggctc  cacctcctt  tcctaggta  tatttattt  cagcacctg  60
ttgatgcag  ttttaatcc  ctacctatt  cactgttgt  actcgttgg  cattatttg  120
tttttgtac  aaaaaaagc  ttgttatag  aatcagcat  ctatttttt  aaatctgga  180
agaagatat  ctggtgact  gaangtatg  gcccggg  217



<210> 8991
<211> 655
<212> PRT
<213> Homo sapiens
<308> NP_006779
<400> 8991

Met Thr Glu Cys Phe Leu Pro Pro Thr Ser Ser Pro Ser Glu His Arg 
  1               5                  10                  15
Arg Val Glu His Gly Ser Gly Leu Thr Arg Thr Pro Ser Ser Glu Glu 
             20                  25                  30
Ile Ser Pro Thr Lys Phe Pro Gly Leu Tyr Arg Thr Gly Glu Pro Ser 
         35                  40                  45
Pro Pro His Asp Ile Leu His Glu Pro Pro Asp Val Val Ser Asp Asp 
     50                  55                  60
Glu Lys Asp His Gly Lys Lys Lys Gly Lys Phe Lys Lys Lys Glu Lys 
 65                  70                  75                  80
Arg Thr Glu Gly Tyr Ala Ala Phe Gln Glu Asp Ser Ser Gly Asp Glu 
                 85                  90                  95
Ala Glu Ser Pro Ser Lys Met Lys Arg Ser Lys Gly Ile His Val Phe 
             100                105                110
Lys Lys Pro Ser Phe Ser Lys Lys Lys Glu Lys Asp Phe Lys Ile Lys 
         115                120                125
Glu Lys Pro Lys Glu Glu Lys His Lys Glu Glu Lys His Lys Glu Glu 
     130                135                140
Lys His Lys Glu Lys Lys Ser Lys Asp Leu Thr Ala Ala Asp Val Val 
 145                150                155                160
Lys Gln Trp Lys Glu Lys Lys Lys Lys Lys Lys Pro Ile Gln Glu Pro 
                 165                170                175
Glu Val Pro Gln Ile Asp Val Pro Asn Leu Lys Pro Ile Phe Gly Ile 
             180                185                190
Pro Leu Ala Asp Ala Val Glu Arg Thr Met Met Tyr Asp Gly Ile Arg 
         195                200                205
Leu Pro Ala Val Phe Arg Glu Cys Ile Asp Tyr Val Glu Lys Tyr Gly 
     210                215                220
Met Lys Cys Glu Gly Ile Tyr Arg Val Ser Gly Ile Lys Ser Lys Val 
 225                230                235                240
Asp Glu Leu Lys Ala Ala Tyr Asp Arg Glu Glu Ser Thr Asn Leu Glu 
                 245                250                255
Asp Tyr Glu Pro Asn Thr Val Ala Ser Leu Leu Lys Gln Tyr Leu Arg 
             260                265                270
Asp Leu Pro Glu Asn Leu Leu Thr Lys Glu Leu Met Pro Arg Phe Glu 
         275                280                285
Glu Ala Cys Gly Arg Thr Thr Glu Thr Glu Lys Val Gln Glu Phe Gln 
     290                295                300
Arg Leu Leu Lys Glu Leu Pro Glu Cys Asn Tyr Leu Leu Ile Ser Trp 
 305                310                315                320
Leu Ile Val His Met Asp His Val Ile Ala Lys Glu Leu Glu Thr Lys 
                 325                330                335
Met Asn Ile Gln Asn Ile Ser Ile Val Leu Ser Pro Thr Val Gln Ile 
             340                345                350
Ser Asn Arg Val Leu Tyr Val Phe Phe Thr His Val Gln Glu Leu Phe 
         355                360                365
Gly Asn Val Val Leu Lys Gln Val Met Lys Pro Leu Arg Trp Ser Asn 
     370                375                380
Met Ala Thr Met Pro Thr Leu Pro Glu Thr Gln Ala Gly Ile Lys Glu 
 385                390                395                400
Glu Ile Arg Arg Gln Glu Phe Leu Leu Asn Cys Leu His Arg Asp Leu 
                 405                410                415
Gln Gly Gly Ile Lys Asp Leu Ser Lys Glu Glu Arg Leu Trp Glu Val 
             420                425                430
Gln Arg Ile Leu Thr Ala Leu Lys Arg Lys Leu Arg Glu Ala Lys Arg 
         435                440                445
Gln Glu Cys Glu Thr Lys Ile Ala Gln Glu Ile Ala Ser Leu Ser Lys 
     450                455                460
Glu Asp Val Ser Lys Glu Glu Met Asn Glu Asn Glu Glu Val Ile Asn 
 465                470                475                480
Ile Leu Leu Ala Gln Glu Asn Glu Ile Leu Thr Glu Gln Glu Glu Leu 
                 485                490                495
Leu Ala Met Glu Gln Phe Leu Arg Arg Gln Ile Ala Ser Glu Lys Glu 
             500                505                510
Glu Ile Glu Arg Leu Arg Ala Glu Ile Ala Glu Ile Gln Ser Arg Gln 
         515                520                525
Gln His Gly Arg Ser Glu Thr Glu Glu Tyr Ser Ser Glu Ser Glu Ser 
     530                535                540
Glu Ser Glu Asp Glu Glu Glu Leu Gln Ile Ile Leu Glu Asp Leu Gln 
 545                550                555                560
Arg Gln Asn Glu Glu Leu Glu Ile Lys Asn Asn His Leu Asn Gln Ala 
                 565                570                575
Ile His Glu Glu Arg Glu Ala Ile Ile Glu Leu Arg Val Gln Leu Arg 
             580                585                590
Leu Leu Gln Met Gln Arg Ala Lys Ala Glu Gln Gln Ala Gln Glu Asp 
         595                600                605
Glu Glu Pro Glu Trp Arg Gly Gly Ala Val Gln Pro Pro Arg Asp Gly 
     610                615                620
Val Leu Glu Pro Lys Ala Ala Lys Glu Gln Pro Lys Ala Gly Lys Glu 
 625                630                635                640
Pro Ala Lys Pro Ser Pro Ser Arg Asp Arg Lys Glu Thr Ser Ile 
                 645                650                655



<210> 8992
<211> 4104
<212> DNA
<213> Rattus norvegicus
<308> U82626
<400> 8992

gaggggccg  tctgcgtct  tcctgaccc  gccgccgcg  tgttgcggt  ctgaggtga  60
gctttcctc  tgcggaggg  cgcggagcc  tgtacatca  gcaggtgat  atccagggc  120
tccgaagtt  ccgagatca  acaattgta  atcccttca  ttcaaaaca  aatgttatt  180
tgggcagaa  tggatctgg  aaaagcaac  ttttttatg  aatccagtt  gttctcagt  240
atgaattta  tcatcttcg  ccagagcag  gattggctt  gttgcacga  ggtacaggt  300
ctcgtgtta  ttctgcttt  gtggaaatc  tttttgaca  ttcagacaa  cggttacca  360
ttgataaag  ggaagtttc  cttcgaaga  ttattggtg  caaaaaaga  cagtatttc  420
tagataaga  gatggtcac  aaaaatgat  tgatgaatc  ccttgaaag  gctgggttt  480
cgagaagta  tccttatta  attgttaaa  aaggaaaga  caaccaaat  gcaacagca  540
cggattctc  gagattaaa  ctgttgaga  aagtagctg  cactcgagt  tatgacgag  600
gcaaagagg  aagcatctc  ctgatgaaa  aaacagagg  caaacggga  aagatcaat  660
agttgttaa  atacattga  gagcgatta  atactctag  ggaggagaa  gaggaactg  720
cccagtatc  gaagtggga  aaaatgagg  gtgccctgg  gtacaccat  tacaaccag  780
agctcaacg  gactcgcgc  aagcttgat  agctttctg  taagcgaga  acaagcgga  840
agaaatcca  acaattaag  gatgcccag  aggatgcaa  agataaaat  gaggatatt  900
agcgccaag  tagagaact  aaaacaaaa  tttcagcca  gaaagaaga  aaagaacag  960
tcagtgcgg  gagacaaga  cagattaag  aaaggacca  gctggagct  aaagccaag  1020
acttacagg  tgagctggc  gggaacagt  agcagcgga  acgtttatt  aaagaaaga  1080
agaagctgc  tgaaaaaat  gaagaaaag  agaaagaac  ggcagaaac  gaaccgaaa  1140
tcaacagcg  aaaggaaaa  gaagagcga  gaattgcta  attggctca  gctacacag  1200
aaagaactg  tctttatgc  aagcagggt  gaggaagcc  gtttacatc  aaagaagaa  1260
gagataagt  gattaagaa  gaactgaag  ctttagatc  ggctattaa  gataagaaa  1320
gacagattg  tgctataca  aaggatttg  aggataccg  ggccaataa  gagaaaaat  1380
tggagcaat  taataaact  gatcaggat  tcaatgaag  caaagctcg  gttgaagaa  1440
tggacagaa  atattatga  gtgaaaaat  agaaagatg  actacaaag  gaaagaaat  1500
acttgtgga  agaggagaa  gcagaacag  aagcacttg  cgctaagag  gaagacctt  1560
agaagaagc  gcagcttct  agagcggca  caggaaagg  cattttaaa  ggaatcgac  1620
gcattaaca  agtgttaga  catttccgg  ggaagggta  aaaccagca  gtgcaaaat  1680
gctaccatg  catcgtgat  aataacttt  agtgcgaac  agctttcta  acttgtgtg  1740
aagtcactg  cggtaacag  ttattctat  acattgtcg  ttcagatga  gtcagcacg  1800
agatattaa  ggagttcaa  aaaatgaat  ttcctggag  ggtgacttt  ctgcctctt  1860
acaagttag  tgtgaggga  actgcctat  ctgaaacta  cgatgctat  cctatgatc  1920
gtaagctga  gtacaatcc  agattcgac  aagctttca  acatgtgtt  ggaaagaca  1980
tcatctgtc  gagcatgga  gtttccact  agctagctc  tgccttcac  atggactgc  2040
ttactctgg  aggtgatca  gtcagccat  gaggtgctc  gactggagg  tattacgac  2100
caagaaagt  tcgccttga  ttacagaag  atgttagga  agcagagga  gagctgggt  2160
agctcgaag  taagctcaa  gaaaacctg  gcagaaaca  tgaaaggat  aataatgaa  2220
ttgatcaat  gatgaacca  atgcagcag  tagagaccc  acagagaaa  tttaaagca  2280
ccagagata  caccttatc  gagatgaag  tgctaaaag  gaagagaca  cagtcagaa  2340
agaccttca  gccaaagca  cgcagtttg  agagtctgg  ggccagtct  cacgctatg  2400
agtcgacca  agagtcgct  aaggcagag  tagggacag  tttgccctc  cagctcagc  2460
tggaagacc  gaaaagagt  gacgcactg  atgacgaga  ccggcagct  cagcagaaa  2520
acagacagc  gctgaatga  agaattaaa  tagaaggca  tattactcg  gtagagact  2580
acctcaatg  gaatctgag  aaacgtctg  accaagtag  gcaggaact  aatgaactg  2640
gagagacag  aggtggcac  gttcttact  ccaccacgt  acaacttga  gctattaat  2700
aaagagtga  agatactat  gcaagatca  aagatttgg  taattccat  gacaaaaca  2760
aagctggaa  taaagagct  cagaaaagc  tggagcgct  gaagaacat  gagaaggag  2820
acatggatg  cataaatca  gacactaaa  agctggaga  gatgaccaa  cgacagggc  2880
tgctgttga  gaagaaaga  gagtgcatg  agaagatcc  agagctggg  tcccttccc  2940
aggaagcat  tgaaaagta  cagacactg  gcctgaagc  gttgtttcg  aaacttgag  3000
agtgcaaca  agagttgaa  aagtacagc  atgtcaaca  gaaggctct  gaccagttt  3060
tgaatttct  tgagcagaa  gagaaactg  taaagcgac  ggaagaatt  gacaggggc  3120
acaagtcaa  catggagtt  atgaatgta  tcgaactta  aaaatatga  gctatccag  3180
taaccttca  acaggtatc  aagaacttt  gtgaagttt  ccagaagtt  gtacctggg  3240
caaaagcga  cttggtgat  aagaaagga  acgtggagg  cagccagtc  caggacgaa  3300
gagagggga  cggcgagag  gagaggggc  ctgggtcac  aagcagcgt  ccatcagtt  3360
accagttca  aggagtcgg  atcagggta  catttacag  aaagcaagg  gagatgaga  3420
aaatgcagc  gctttcagg  gggcagaag  ctctggtag  ccttgctct  atttttgcc  3480
ttcagaagt  tgaccctgc  cctttctac  tgtttgatg  gatcgacca  gctttggat  3540
ctcagcaca  aaaagctgt  tcagatatg  ttatggaac  agctgtaca  gcccagttt  3600
tcactacca  ttttaggcc  gaactgctt  agtctgctg  taaatcctc  gggaagtca  3660
aataaggta  tcacatcga  gtgatcaca  caagagatg  ccaaagact  tgtagaaga  3720
gataccacg  atggttaac  gaaagataa  gcctgccgt  ttggaagat  tgtatagta  3780
tgtggtccg  acctgggaa  gtaaatttt  aaaataata  ttggttatt  ctgagtttt  3840
ggatttaga  tacacagtc  ttttatact  gtctttgta  tttataagc  cccctgtaa  3900
gttacattt  tacgtatag  cgaggaatt  tatttccta  acgacaaaa  gtaagtgtc  3960
tcctatttt  aatcttttg  gattctaaa  attcccaat  attttatag  ttctattaa  4020
taattggtt  gtgcataac  tagtgtaaa  gtggccttt  gtctttgta  ttgttagaa  4080
cattcggtg  gtattttgc  taag  4104



<210> 8993
<211> 1191
<212> PRT
<213> Rattus norvegicus
<308> AAB96342
<400> 8993

Met Tyr Ile Lys Gln Val Ile Ile Gln Gly Phe Arg Ser Tyr Arg Asp 
  1               5                  10                  15
Gln Thr Ile Val Asp Pro Phe Ser Ser Lys His Asn Val Ile Val Gly 
             20                  25                  30
Arg Asn Gly Ser Gly Lys Ser Asn Phe Phe Tyr Ala Ile Gln Phe Val 
         35                  40                  45
Leu Ser Asp Glu Phe Ser His Leu Arg Pro Glu Gln Arg Leu Ala Leu 
     50                  55                  60
Leu His Glu Gly Thr Gly Pro Arg Val Ile Ser Ala Phe Val Glu Ile 
 65                  70                  75                  80
Ile Phe Asp Asn Ser Asp Asn Arg Leu Pro Ile Asp Lys Glu Glu Val 
                 85                  90                  95
Ser Leu Arg Arg Val Ile Gly Ala Lys Lys Asp Gln Tyr Phe Leu Asp 
             100                105                110
Lys Lys Met Val Thr Lys Asn Asp Val Met Asn Leu Leu Glu Ser Ala 
         115                120                125
Gly Phe Ser Arg Ser Asn Pro Tyr Tyr Ile Val Lys Gln Gly Lys Ile 
     130                135                140
Asn Gln Met Ala Thr Ala Pro Asp Ser Gln Arg Leu Lys Leu Leu Arg 
 145                150                155                160
Glu Val Ala Gly Thr Arg Val Tyr Asp Glu Arg Lys Glu Glu Ser Ile 
                 165                170                175
Ser Leu Met Lys Glu Thr Glu Gly Lys Arg Glu Lys Ile Asn Glu Leu 
             180                185                190
Leu Lys Tyr Ile Glu Glu Arg Leu His Thr Leu Glu Glu Glu Lys Glu 
         195                200                205
Glu Leu Ala Gln Tyr Gln Lys Trp Asp Lys Met Arg Arg Ala Leu Glu 
     210                215                220
Tyr Thr Ile Tyr Asn Gln Glu Leu Asn Glu Thr Arg Ala Lys Leu Asp 
 225                230                235                240
Glu Leu Ser Ala Lys Arg Glu Thr Ser Gly Glu Lys Ser Arg Gln Leu 
                 245                250                255
Arg Asp Ala Gln Gln Asp Ala Arg Asp Lys Met Glu Asp Ile Glu Arg 
             260                265                270
Gln Val Arg Glu Leu Lys Thr Lys Ile Ser Ala Met Lys Glu Glu Lys 
         275                280                285
Glu Gln Leu Ser Ala Glu Arg Gln Glu Gln Ile Lys Gln Arg Thr Lys 
     290                295                300
Leu Glu Leu Lys Ala Lys Asp Leu Gln Asp Glu Leu Ala Gly Asn Ser 
 305                310                315                320
Glu Gln Arg Lys Arg Leu Leu Lys Glu Arg Gln Lys Leu Leu Glu Lys 
                 325                330                335
Ile Glu Glu Lys Gln Lys Glu Leu Ala Glu Thr Glu Pro Lys Phe Asn 
             340                345                350
Ser Val Lys Glu Lys Glu Glu Arg Gly Ile Ala Arg Leu Ala Gln Ala 
         355                360                365
Thr Gln Glu Arg Thr Asp Leu Tyr Ala Lys Gln Gly Arg Gly Ser Gln 
     370                375                380
Phe Thr Ser Lys Glu Glu Arg Asp Lys Trp Ile Lys Lys Glu Leu Lys 
 385                390                395                400
Ser Leu Asp Gln Ala Ile Asn Asp Lys Lys Arg Gln Ile Ala Ala Ile 
                 405                410                415
His Lys Asp Leu Glu Asp Thr Glu Ala Asn Lys Glu Lys Asn Leu Glu 
             420                425                430
Gln Tyr Asn Lys Leu Asp Gln Asp Leu Asn Glu Val Lys Ala Arg Val 
         435                440                445
Glu Glu Leu Asp Arg Lys Tyr Tyr Glu Val Lys Asn Lys Lys Asp Glu 
     450                455                460
Leu Gln Ser Glu Arg Asn Tyr Leu Trp Arg Glu Glu Asn Ala Glu Gln 
 465                470                475                480
Gln Ala Leu Ala Ala Lys Arg Glu Asp Leu Glu Lys Lys Gln Gln Leu 
                 485                490                495
Leu Arg Ala Ala Thr Gly Lys Ala Ile Leu Asn Gly Ile Asp Ser Ile 
             500                505                510
Asn Lys Val Leu Asp His Phe Arg Arg Lys Gly Ile Asn Gln His Val 
         515                520                525
Gln Asn Gly Tyr His Gly Ile Val Met Asn Asn Phe Glu Cys Glu Pro 
     530                535                540
Ala Phe Tyr Thr Cys Val Glu Val Thr Ala Gly Asn Arg Leu Phe Tyr 
 545                550                555                560
His Ile Val Asp Ser Asp Glu Val Ser Thr Lys Ile Leu Met Glu Phe 
                 565                570                575
Asn Lys Met Asn Leu Pro Gly Glu Val Thr Phe Leu Pro Leu Asn Lys 
             580                585                590
Leu Asp Val Arg Asp Thr Ala Tyr Pro Glu Thr Asn Asp Ala Ile Pro 
         595                600                605
Met Ile Ser Lys Leu Arg Tyr Asn Pro Arg Phe Asp Lys Ala Phe Lys 
     610                615                620
His Val Phe Gly Lys Thr Leu Ile Cys Arg Ser Met Glu Val Ser Thr 
 625                630                635                640
Gln Leu Ala Arg Ala Phe Thr Met Asp Cys Ile Thr Leu Glu Gly Asp 
                 645                650                655
Gln Val Ser His Arg Gly Ala Leu Thr Gly Gly Tyr Tyr Asp Thr Arg 
             660                665                670
Lys Ser Arg Leu Glu Leu Gln Lys Asp Val Arg Lys Ala Glu Glu Glu 
         675                680                685
Leu Gly Glu Leu Glu Ala Lys Leu Asn Glu Asn Leu Arg Arg Asn Ile 
     690                695                700
Glu Arg Ile Asn Asn Glu Ile Asp Gln Leu Met Asn Gln Met Gln Gln 
 705                710                715                720
Ile Glu Thr Gln Gln Arg Lys Phe Lys Ala Ser Arg Asp Ser Thr Leu 
                 725                730                735
Ser Glu Met Lys Met Leu Lys Glu Lys Arg Gln Gln Ser Glu Lys Thr 
             740                745                750
Phe Met Pro Lys Gln Arg Ser Leu Gln Ser Leu Glu Ala Ser Leu His 
         755                760                765
Ala Met Glu Ser Thr Arg Glu Ser Leu Lys Ala Glu Leu Gly Thr Asp 
     770                775                780
Leu Pro Ser Gln Leu Ser Leu Glu Asp Gln Lys Arg Val Asp Ala Leu 
 785                790                795                800
Asn Asp Glu Ile Arg Gln Leu Gln Gln Lys Asn Arg Gln Leu Leu Asn 
                 805                810                815
Glu Arg Ile Lys Leu Glu Gly Ile Ile Thr Arg Val Glu Thr Tyr Leu 
             820                825                830
Asn Glu Asn Leu Arg Lys Arg Leu Asp Gln Val Glu Gln Glu Leu Asn 
         835                840                845
Glu Leu Arg Glu Thr Glu Gly Gly Thr Val Leu Thr Ala Thr Thr Ser 
     850                855                860
Gln Leu Glu Ala Ile Asn Lys Arg Val Lys Asp Thr Met Ala Arg Ser 
 865                870                875                880
Glu Asp Leu Asp Asn Ser Ile Asp Lys Thr Glu Ala Gly Ile Lys Glu 
                 885                890                895
Leu Gln Lys Ser Met Glu Arg Trp Lys Asn Met Glu Lys Glu His Met 
             900                905                910
Asp Ala Ile Asn His Asp Thr Lys Glu Leu Glu Lys Met Thr Asn Arg 
         915                920                925
Gln Gly Met Leu Leu Lys Lys Lys Glu Glu Cys Met Lys Lys Ile Arg 
     930                935                940
Glu Leu Gly Ser Leu Pro Gln Glu Ala Phe Glu Lys Tyr Gln Thr Leu 
 945                950                955                960
Ser Leu Lys Gln Leu Phe Arg Lys Leu Glu Gln Cys Asn Thr Glu Leu 
                 965                970                975
Lys Lys Tyr Ser His Val Asn Lys Lys Ala Leu Asp Gln Phe Val Asn 
             980                985                990
Phe Ser Glu Gln Lys Glu Lys Leu Ile Lys Arg Gln Glu Glu Leu Asp 
         995                1000                1005
Arg Gly Tyr Lys Ser Ile Met Glu Leu Met Asn Val Leu Glu Leu Arg 
     1010                1015                1020
Lys Tyr Glu Ala Ile Gln Leu Thr Phe Lys Gln Val Ser Lys Asn Phe 
 1025                1030                1035                1040
Ser Glu Val Phe Gln Lys Leu Val Pro Gly Ala Lys Ala Thr Leu Val 
                 1045                1050                1055
Met Lys Lys Gly Asp Val Glu Gly Ser Gln Ser Gln Asp Glu Gly Glu 
             1060                1065                1070
Gly Ser Gly Glu Ser Glu Arg Gly Ser Gly Ser Gln Ser Ser Val Pro 
         1075                1080                1085
Ser Val Asp Gln Phe Thr Gly Val Gly Ile Arg Val Ser Phe Thr Gly 
     1090                1095                1100
Lys Gln Gly Glu Met Arg Glu Met Gln Gln Leu Ser Gly Gly Gln Lys 
 1105                1110                1115                1120
Ser Leu Val Ala Leu Ala Leu Ile Phe Ala Ile Gln Lys Cys Asp Pro 
                 1125                1130                1135
Ala Pro Phe Tyr Leu Phe Asp Glu Ile Asp Gln Ala Leu Asp Ala Gln 
             1140                1145                1150
His Arg Lys Ala Val Ser Asp Met Ile Met Glu Leu Ala Val His Ala 
         1155                1160                1165
Gln Phe Ile Thr Thr Thr Phe Arg Pro Glu Leu Leu Glu Ser Ala Asp 
     1170                1175                1180
Lys Ser Ser Gly Lys Ser Glu 
 1185                1190



<210> 8994
<211> 3903
<212> DNA
<213> Rattus norvegicus
<308> U83119
<400> 8994

aggaagcaa  aaactaatc  tcttggcaa  aaaacaaag  gaatgaaag  acacaaaca  60
aacctcaca  ccaaatatg  atataaagg  agcaataat  actattcct  aatatctct  120
aatatcaat  gcctcaact  cccaataaa  agacataga  taacaaact  gatacgcaa  180
gaggaccct  cattctgct  cctacagga  acacacctc  gagacaaag  cagacatta  240
ctcagagtg  aaggctgga  aacaacttt  caagcaaat  gtcagaaga  gcaagctgg  300
gtagccatt  taatatcaa  taaaatcaa  ttccaacta  aagtcatca  aaaagataa  360
gaaggacac  tcatattca  caaaggaaa  atccaccaa  atgaactct  aatcctaaa  420
atctatgcc  caaatacaa  ggcacctac  tacgtaaaa  aaaccttac  aaagctcaa  480
acacacatt  cacctcaca  aataatagt  ggagacttc  acaccccac  ctcatcaat  540
gacagatca  ggaaacaga  attaaacag  gatgtcgac  gactaagag  agtcatgag  600
caaatggac  taacggata  ttatagaac  ttctatcct  aagcaaaag  atatacctt  660
ttctcagct  ctcatggta  tttctccaa  attgaccat  taattggtc  aaaaacggg  720
ctcaacagg  acagaaaga  agagataat  ccatgcatg  tatcggacc  ccacggcct  780
aaactggtc  tcaataaca  taagggaag  atgcccaca  atacgtgga  attgaacaa  840
gctctactc  atgataacc  ggtcaagga  gaaataaag  aagaaatta  aaagttttt  900
gaatttaat  aaaatgaag  tacaacata  tcaaactta  gggacacaa  gaaagctgt  960
ctaagagga  aactcatag  gctgagtgc  tgcagaaag  aacaggaaa  agcatatgt  1020
agcagcttg  caacacacc  aaaagctct  gaacaaaaa  aagcaaata  gcccaggag  1080
agtagaagg  aggaaataa  caaactcag  gctgaaatc  accaagtag  aacaaaaag  1140
accatagaa  gaatcaaca  aaccaaaag  tggttcttt  agaaaatca  caagataga  1200
aaaccctta  ccagactaa  gagaggaca  agagagtgc  tccaaatta  caaaatcag  1260
aatgaaaag  gagacataa  tacagattc  gaggaaatt  aaaaaatca  cagatctta  1320
tataaaaac  tatattcaa  aaaatttga  aatcttcag  aaatggaca  tttcctaga  1380
agataccag  tatcgaagt  aaatcagga  cagataaac  agttaaaca  ccccataac  1440
cctaaggaa  tagaagcag  cactaaagg  ctcccaacc  aaaagagcc  aggtccaga  1500
gggtttagt  cagaattct  tcaaacctt  atagaagac  tcataccaa  attatccaa  1560
ctattccac  aaattgaaa  agatggagc  ctaccgaat  ccttctatg  agccacaat  1620
actcttata  ctaaaccac  caaagacac  acaaagaaa  agaacttca  accaatttc  1680
cttatgaat  tcaacgcaa  aatactcaa  aaaattctg  caaaccgaa  tcaagagca  1740
atcaaaaca  tcatccacc  tgatcaagt  ggcttcatc  caggcatgc  gggatggtt  1800
aatatacgg  aaaccatca  cgtgatcca  tatataaac  aactgaaag  acagaacca  1860
atgatcatt  cattagatg  tgagaaagc  tttgacaaa  ttcaacacc  cttcatgat  1920
aaagtcctg  aaagaatag  aattcaagg  ccataccta  acatagtaa  agccatata  1980
agcaaacca  ttgctaaca  taaactaaa  ggagagaaa  ttgaagcaa  cccactaaa  2040
tcagggact  gacaaggct  cccactctc  ccctactta  tcaatatag  tcttgaagt  2100
ctagccaga  caatcagaa  acaaaagga  atcaagggg  tacagatcg  aaaagaaga  2160
gtcaaaata  cactatttg  agatgacat  atagtatat  taagtgatc  caaaagttc  2220
accagagaa  aactaaagc  gataaacaa  ttcagcaaa  tggctgggt  taaaattaa  2280
tcaaataaa  cagttgcct  cctctatac  aaagagaaa  aagccgaga  agaaattag  2340
gaaacgaca  ccttcataa  agacccaaa  aatataaag  acctcggtg  gactttaac  2400
aagcaagta  aagatctgt  caataagaa  ttcaagaca  tgaggaaag  aattgaaga  2460
gacctcaga  gatggaaag  tctcccatg  tcatggatt  gcaggatta  tatagtaaa  2520
atggccatt  taccaaaag  aatctacag  ttcaatgca  tccccatca  aataccaat  2580
caattcttc  aagagttag  cagaacaat  tgcaaattc  tctggaata  caaaaaacc  2640
aggatagct  aagctatcc  caacaataa  aggacttca  ggggaatca  tatccctga  2700
ctcaagcag  attacagag  aatagtgat  aaaactgca  ggtattggt  cagagacag  2760
cagatagac  aatggaata  aattgaaga  ccagaaatg  actcacaca  ctatggtca  2820
ttgattttt  acaaaggag  caaaaccat  caatggaaa  aagatagca  tttcagcaa  2880
tggtgctgg  tcaactgga  ggcaacatg  agaagaatg  agatcgatc  atgcttatc  2940
ccctgtaca  agcttaagt  caagtggat  aaggacctc  acatcaaac  agacacact  3000
aaactaata  aagaaaaac  agggaagca  ctggaacac  tgggcactg  aaaaaattt  3060
ctgaacaaa  caccaatgg  ttatgctct  agatcaaga  ttgacaaat  ggatctcat  3120
aaactgcaa  gcttctgta  ggcaaagga  actgtggtt  ggacaaaac  gcaaccaac  3180
gattgggaa  agatcttta  caaccctac  acagataga  gccttatat  caaaatata  3240
aaagaactc  agaagttag  ccgcaggga  acaaataac  ctattaaaa  atggggttc  3300
gagctaaac  aagaattca  agctgagga  tgccgaatg  ctgagaaac  cctaaagaa  3360
tgttcaaca  ctttagtca  aagggaaat  caaatcaaa  caaccctga  atttcacct  3420
acaccagtg  gaatggcta  gatcaaaaa  tcaggggac  acagatgct  gcgaggatg  3480
ggagaaaga  gaacactcc  ccattgttg  tgggattgc  aactggtac  accattctg  3540
aaatcagtc  ggaggatcc  cagaaaatt  gacattgaa  tgcctgagg  tccagctat  3600
cctctcttg  gcatatacc  aaaagatgc  ccaacatat  aaaaagaca  gtgctccac  3660
atgttcatt  cagccttat  tataatagc  agaagctgg  aagaaccca  atgcccttc  3720
acagaggaa  ggatacaga  aatgtggta  atctacaca  tggaatatt  ctcagctat  3780
aaaaacaac  actttatga  attcgtagg  aaatggctg  aactggaaa  tatcatcct  3840
agtgagcta  cccaaacac  gaaagacat  catggtatg  actcactga  atgtggcta  3900
tag  3903



<210> 8995
<211> 1300
<212> PRT
<213> Rattus norvegicus
<308> AAB41224
<400> 8995

Arg Lys Gln Glu Thr Asn Arg Leu Gly Asn Lys Thr Lys Arg Met Lys 
  1               5                  10                  15
Ala His Lys His Asn Leu Thr Ser Lys Tyr Glu Tyr Lys Gly Ser Asn 
             20                  25                  30
Asn His Tyr Ser Leu Ile Ser Leu Asn Ile Asn Gly Leu Asn Ser Pro 
         35                  40                  45
Ile Lys Arg His Arg Leu Thr Asn Trp Ile Arg Asn Glu Asp Pro Ala 
     50                  55                  60
Phe Cys Cys Leu Gln Glu Thr His Leu Arg Asp Lys Asp Arg His Tyr 
 65                  70                  75                  80
Leu Arg Val Lys Gly Trp Lys Thr Thr Phe Gln Ala Asn Gly Gln Lys 
                 85                  90                  95
Lys Gln Ala Gly Val Ala Ile Leu Ile Ser Asn Lys Ile Asn Phe Gln 
             100                105                110
Leu Lys Val Ile Lys Lys Asp Lys Glu Gly His Phe Ile Phe Ile Lys 
         115                120                125
Gly Lys Ile His Gln Asp Glu Leu Ser Ile Leu Asn Ile Tyr Ala Pro 
     130                135                140
Asn Thr Arg Ala Pro Thr Tyr Val Lys Glu Thr Leu Leu Lys Leu Lys 
 145                150                155                160
Thr His Ile Ala Pro His Thr Ile Ile Val Gly Asp Phe Asn Thr Pro 
                 165                170                175
Leu Ser Ser Met Asp Arg Ser Trp Lys Gln Lys Leu Asn Ser Asp Val 
             180                185                190
Asp Arg Leu Arg Glu Val Met Ser Gln Met Asp Leu Thr Asp Ile Tyr 
         195                200                205
Arg Thr Phe Tyr Pro Lys Ala Lys Gly Tyr Thr Phe Phe Ser Ala Pro 
     210                215                220
His Gly Thr Phe Ser Lys Ile Asp His Ile Ile Gly Gln Lys Thr Gly 
 225                230                235                240
Leu Asn Arg Tyr Arg Lys Ile Glu Ile Ile Pro Cys Met Leu Ser Asp 
                 245                250                255
His His Gly Leu Lys Leu Val Phe Asn Asn Asn Lys Gly Arg Met Pro 
             260                265                270
Thr Tyr Thr Trp Lys Leu Asn Asn Ala Leu Leu Asn Asp Asn Leu Val 
         275                280                285
Lys Glu Glu Ile Lys Lys Glu Ile Lys Lys Phe Leu Glu Phe Asn Glu 
     290                295                300
Asn Glu Asp Thr Thr Tyr Ser Asn Leu Trp Asp Thr Met Lys Ala Val 
 305                310                315                320
Leu Arg Gly Lys Leu Ile Ala Leu Ser Ala Cys Arg Lys Lys Gln Glu 
                 325                330                335
Arg Ala Tyr Val Ser Ser Leu Thr Thr His Leu Lys Ala Leu Glu Gln 
             340                345                350
Lys Glu Ala Asn Thr Pro Arg Arg Ser Arg Arg Gln Glu Ile Ile Lys 
         355                360                365
Leu Arg Ala Glu Ile Asn Gln Val Glu Thr Lys Arg Thr Ile Glu Arg 
     370                375                380
Ile Asn Arg Thr Lys Ser Trp Phe Phe Glu Lys Ile Asn Lys Ile Asp 
 385                390                395                400
Lys Pro Leu Ala Arg Leu Thr Arg Gly His Arg Glu Cys Val Gln Ile 
                 405                410                415
Asn Lys Ile Arg Asn Glu Lys Gly Asp Ile Thr Thr Asp Ser Glu Glu 
             420                425                430
Ile Gln Lys Ile Ile Arg Ser Tyr Tyr Lys Asn Leu Tyr Ser Thr Lys 
         435                440                445
Phe Glu Asn Leu Gln Glu Met Asp Asn Phe Leu Asp Arg Tyr Gln Val 
     450                455                460
Ser Lys Leu Asn Gln Glu Gln Ile Asn Gln Leu Asn Asn Pro Ile Thr 
 465                470                475                480
Pro Lys Glu Ile Glu Ala Val Thr Lys Gly Leu Pro Thr Lys Lys Ser 
                 485                490                495
Pro Gly Pro Asp Gly Phe Ser Ala Glu Phe Tyr Gln Thr Phe Ile Glu 
             500                505                510
Asp Leu Ile Pro Ile Leu Ser Lys Leu Phe His Lys Ile Glu Thr Asp 
         515                520                525
Gly Ala Leu Pro Asn Ser Phe Tyr Glu Ala Thr Ile Thr Leu Ile Pro 
     530                535                540
Lys Pro His Lys Asp Thr Thr Lys Lys Glu Asn Phe Arg Pro Ile Ser 
 545                550                555                560
Leu Met Asn Ile Asn Ala Lys Ile Leu Asn Lys Ile Leu Ala Asn Arg 
                 565                570                575
Ile Gln Glu His Ile Lys Thr Ile Ile His His Asp Gln Val Gly Phe 
             580                585                590
Ile Pro Gly Met Gln Gly Trp Phe Asn Ile Arg Lys Thr Ile Asn Val 
         595                600                605
Ile His Tyr Ile Asn Lys Leu Lys Glu Gln Asn His Met Ile Ile Ser 
     610                615                620
Leu Asp Ala Glu Lys Ala Phe Asp Lys Ile Gln His Pro Phe Met Ile 
 625                630                635                640
Lys Val Leu Glu Arg Ile Gly Ile Gln Gly Pro Tyr Leu Asn Ile Val 
                 645                650                655
Lys Ala Ile Tyr Ser Lys Pro Val Ala Asn Ile Lys Leu Asn Gly Glu 
             660                665                670
Lys Leu Glu Ala Ile Pro Leu Lys Ser Gly Thr Arg Gln Gly Cys Pro 
         675                680                685
Leu Ser Pro Tyr Leu Phe Asn Ile Val Leu Glu Val Leu Ala Arg Pro 
     690                695                700
Ile Arg Lys Gln Lys Glu Ile Lys Gly Ile Gln Ile Gly Lys Glu Glu 
 705                710                715                720
Val Lys Ile Ser Leu Phe Ala Asp Asp Met Ile Val Tyr Leu Ser Asp 
                 725                730                735
Pro Lys Ser Ser Thr Arg Glu Gln Leu Lys Leu Ile Asn Asn Phe Ser 
             740                745                750
Lys Val Ala Gly Tyr Lys Ile Asn Ser Asn Lys Ser Val Ala Phe Leu 
         755                760                765
Tyr Thr Lys Glu Lys Gln Ala Glu Lys Glu Ile Arg Glu Thr Thr Pro 
     770                775                780
Phe Ile Ile Asp Pro Asn Asn Ile Lys Tyr Leu Gly Val Thr Leu Thr 
 785                790                795                800
Lys Gln Val Lys Asp Leu Tyr Asn Lys Asn Phe Lys Thr Leu Arg Lys 
                 805                810                815
Glu Ile Glu Glu Asp Leu Arg Arg Trp Lys Asp Leu Pro Cys Ser Trp 
             820                825                830
Ile Gly Arg Ile Asn Ile Val Lys Met Ala Ile Leu Pro Lys Ala Ile 
         835                840                845
Tyr Arg Phe Asn Ala Ile Pro Ile Lys Ile Pro Ile Gln Phe Phe Lys 
     850                855                860
Glu Leu Asp Arg Thr Ile Cys Lys Phe Ile Trp Asn Asn Lys Lys Pro 
 865                870                875                880
Arg Ile Ala Lys Ala Ile Leu Asn Asn Lys Arg Thr Ser Gly Gly Ile 
                 885                890                895
Thr Ile Pro Glu Leu Lys Gln Tyr Tyr Arg Ala Ile Val Ile Lys Thr 
             900                905                910
Ala Trp Tyr Trp Tyr Arg Asp Arg Gln Ile Asp Gln Trp Asn Arg Ile 
         915                920                925
Glu Asp Pro Glu Met Asn Ser His Thr Tyr Gly His Leu Ile Phe Asp 
     930                935                940
Lys Gly Ala Lys Thr Ile Gln Trp Lys Lys Asp Ser Ile Phe Ser Lys 
 945                950                955                960
Trp Cys Trp Phe Asn Trp Arg Ala Thr Cys Arg Arg Met Gln Ile Asp 
                 965                970                975
Pro Cys Leu Ser Pro Cys Thr Lys Leu Lys Ser Lys Trp Ile Lys Asp 
             980                985                990
Leu His Ile Lys Pro Asp Thr Leu Lys Leu Ile Glu Glu Lys Leu Gly 
         995                1000                1005
Lys His Leu Glu His Met Gly Thr Gly Lys Asn Phe Leu Asn Lys Thr 
     1010                1015                1020
Pro Met Ala Tyr Ala Leu Arg Ser Arg Ile Asp Lys Trp Asp Leu Ile 
 1025                1030                1035                1040
Lys Leu Gln Ser Phe Cys Lys Ala Lys Asp Thr Val Val Arg Thr Lys 
                 1045                1050                1055
Arg Gln Pro Thr Asp Trp Glu Lys Ile Phe Thr Asn Pro Thr Thr Asp 
             1060                1065                1070
Arg Gly Leu Ile Ser Lys Ile Tyr Lys Glu Leu Lys Lys Leu Asp Arg 
         1075                1080                1085
Arg Glu Thr Asn Asn Pro Ile Lys Lys Trp Gly Ser Glu Leu Asn Lys 
     1090                1095                1100
Glu Phe Thr Ala Glu Glu Cys Arg Met Ala Glu Lys His Leu Lys Lys 
 1105                1110                1115                1120
Cys Ser Thr Ser Leu Val Ile Arg Glu Met Gln Ile Lys Thr Thr Leu 
                 1125                1130                1135
Arg Phe His Leu Thr Pro Val Arg Met Ala Lys Ile Lys Asn Ser Gly 
             1140                1145                1150
Asp Asn Arg Cys Trp Arg Gly Cys Gly Glu Arg Gly Thr Leu Leu His 
         1155                1160                1165
Cys Trp Trp Asp Cys Lys Leu Val Gln Pro Phe Trp Lys Ser Val Trp 
     1170                1175                1180
Arg Ile Leu Arg Lys Leu Asp Ile Glu Leu Pro Glu Asp Pro Ala Ile 
 1185                1190                1195                1200
Pro Leu Leu Gly Ile Tyr Pro Lys Asp Ala Pro Thr Tyr Lys Lys Asp 
                 1205                1210                1215
Thr Cys Ser Thr Met Phe Ile Ala Ala Leu Phe Ile Ile Ala Arg Ser 
             1220                1225                1230
Trp Lys Glu Pro Arg Cys Pro Ser Thr Glu Glu Trp Ile Gln Lys Met 
         1235                1240                1245
Trp Tyr Ile Tyr Thr Met Glu Tyr Tyr Ser Ala Ile Lys Asn Asn Asp 
     1250                1255                1260
Phe Met Lys Phe Val Gly Lys Trp Leu Glu Leu Glu Asn Ile Ile Leu 
 1265                1270                1275                1280
Ser Glu Leu Thr Gln Thr Gln Lys Asp Ile His Gly Met Tyr Ser Leu 
                 1285                1290                1295
Ile Cys Gly Tyr 
             1300



<210> 8996
<211> 6075
<212> DNA
<213> Homo sapiens
<308> M80340
<400> 8996

gggggagga  ccaagatgg  cgaatagga  cagctccgg  ctacagctc  cagcgtgag  60
gacgcagaa  acggtgatt  ctgcatttc  atctgaggt  ccgggttca  ctcactagg  120
agtgccaga  agtgggcgc  ggccagtgt  tgtgcgcac  gtgcgcgag  cgaagcagg  180
cgaggcatt  cctcacctg  gaagcgcaa  gggtcaggg  gttcccttt  tgagtcaaa  240
aaaggggtg  cggtcgcac  tggaaaatc  ggtcactcc  acccgaata  tgcgctttt  300
agaccggct  aagaaacgg  gcaccacga  actatatcc  acacctggc  cggagggtc  360
tacgcccac  gaatctcgc  gattgctag  acagcagtc  gagatcaaa  tgcaaggcg  420
caacgaggc  gggggaggg  cgcccgcca  tgcccaggc  tgcttaggt  aacaaagca  480
ccgggaagc  cgaactggg  ggagcccac  acagctcaa  gaggcctgc  tgcctctgt  540
ggctccacc  ctgggggca  ggcacagac  aacaaaaag  cagcagtaa  ctctgcaga  600
ttaagtgtc  ctgtctgac  gctttgaag  gagcagtgg  tctcccagc  cgcagctgg  660
gatctgaga  cgggcagac  gactgcctc  tcaagtggg  ccctgactc  tgacccccg  720
gcagcctaa  tgggaggca  cccccagca  gggcacact  acacctcac  cggcagggt  780
ttccaacag  cctgcagct  agggtcctg  ctgttagaa  gaaaactaa  aaccagaaa  840
gacatctac  ccgaaaacc  atctgtaca  caccatcat  aaagaccaa  agtagataa  900
accacaaag  tgggaaaaa  cagaacaga  aaactggaa  ctctaaaac  cagagcgcc  960
ctcctcctc  aaaggaacg  agttcctca  cagcaacag  acaaagctg  atggagaat  1020
attttgacg  gctgagaga  gaaggcttc  gacgatcaa  ttactctga  ctacgggag  1080
acattcaaa  caaaggcaa  gaagttgaa  actttgaaa  aaatttaga  gaatgtata  1140
ctagaatat  caatacaga  aagtgctta  aggagctga  ggagctgaa  accaaggct  1200
gagaactac  tgaagaatg  agaagcctc  ggagccgat  cgatcaact  gaagaaagg  1260
tatcagcaa  ggaagatga  atgaatgaa  tgaagcgag  agggaagtt  agagaaaaa  1320
gaataaaaa  aaatgagca  agcctccaa  aaatatggg  ctatgtgaa  agaccaaat  1380
tacgtctga  tggtgtacc  gaaagtgat  tggagaatg  aaccaagtt  gaaaacact  1440
tgcaggata  tatccagga  aacttcccc  atctagcaa  gcaggccaa  gttcagatt  1500
aggaaatac  gagaacgcc  caaagatac  cctcgagaa  agcaactcc  agacacata  1560
ttgtcagat  caccaaagt  gaaatgaag  aaaaaatgt  aagggcagc  agagagaaa  1620
gtcgggtta  cctcaaagg  aagcccatc  gactaacag  ggatctctc  gcagaaacc  1680
tacaagcca  aagagagtg  gggccaata  tcaacattc  taaagaaaa  aattttcaa  1740
ccagaattt  atatccagc  aaactaagc  tcataagtg  aggagaaat  aaatacttt  1800
tagacaagc  aatgttgag  gattttgtc  ccaccaggc  tgccctaaa  gagctcctg  1860
aggaagcgc  aaacatgga  aggaacaac  ggtaccagc  gctgcaaaa  catgccaaa  1920
tgtaaagac  atcgagact  ggaagaaac  gcatcaact  atgagcaaa  tcaccagct  1980
acatcataa  gacaggatc  aattcacac  taacaatat  aactttaaa  ataaatgga  2040
taaattctg  aattaaaag  cacagactg  caagttgga  aaagagtca  gacccatca  2100
tgtgctgta  tcaggaaac  catctcacg  gcagagaca  acataggct  aaaataaaa  2160
gatggagga  gatctacca  gccaatgga  aacaaaaaa  ggcaggggt  gcaatccta  2220
tctctgata  aacagactt  aaaccaaca  agatcaaaa  agacaaaga  ggccattac  2280
taatggtaa  gggatcaat  caacaagag  agctaacta  cctaaatat  tatgcaccc  2340
atacaggag  acccagatt  ataaagcaa  tcctcagtg  cctacaaag  gacttagac  2400
cccacacat  aataatggg  gactttaac  ccccactgt  aacattaga  agatcaacg  2460
gacagaaag  caacaagga  acccaggaa  tgaactcag  tctgcacca  gcagaccta  2520
tagacatct  cagaactct  caccccaaa  caacagaat  tacattttt  tcagcacca  2580
accacacct  ttccaaaat  gaccacata  ttggaagta  agctctcct  agcaaatgt  2640
aaagaacag  aattataac  aactatctc  cagaccaca  tgcaatcaa  ctagaactc  2700
ggattaaga  tctcactca  agccgctca  ctacatgga  actgaacaa  ctgctcctg  2760
atgactact  ggtacataa  gaaatgaag  cagaaataa  gatgttctt  gaaaccaac  2820
agaacaaag  caccacata  cagaatctc  gggacgcat  caaagcagt  tgtagaggg  2880
aatttatag  actaaatgc  tacaagaga  agcaggaaa  atccaaaat  gacacccta  2940
catcacaat  aaaagaact  gaaaagcaa  agcaaacac  ttcaaaagc  agcagaagg  3000
aagaaataa  taaaatcag  gcagaactg  aggaaatag  gacacaaaa  acccttcaa  3060
aaatcaatg  atccaggag  tggtttttt  aaaggatca  caaaattga  agaccgcta  3120
caagactaa  aaagaaaaa  agagagaag  atcaaatag  cacaataaa  aatgataaa  3180
gggatatca  caccgatcc  acagaaata  aaactacca  cagagaata  tacaaacac  3240
tctacgcaa  taaactaga  aatctagaa  aaatggata  attcctcga  acatacact  3300
tcccaagac  aaaccagga  gaagttgaa  ctctgaata  accaataac  ggctctgaa  3360
ttgtggcaa  aatcaatag  ttaccaacc  aaaagagtc  aggaccaga  ggattcaca  3420
ccgaattct  ccagaggta  atggaggaa  tggtaccat  ccttctgaa  ctattccaa  3480
caatagaaa  agagggaat  ctccctaac  cattttatg  ggccagcat  attctgata  3540
caaagccgg  cagagacac  accaaaaaa  agaatttta  accaatatc  ttgatgaac  3600
ttgatgcaa  aatcctcaa  aaaatactg  caaaccgaa  ccagcagca  atcaaaaag  3660
ttatccacc  tgatcaagt  ggcttcatc  ctgggatgc  aggctggtt  aatatacgc  3720
aatcaataa  tgtaatcca  catataaac  gagccaatg  caaaaacca  atgattatc  3780
caatagatg  agaaaaagc  tttgacaaa  ttcaacaac  cttcatgct  aaaactctc  3840
ataaattag  tattgatgg  acgtatttc  aaataataa  agctatcta  gacaaaccc  3900
cagccaata  catactgaa  gggcaaaaa  tggaagcat  ccctttgaa  accggcaca  3960
gacagggat  ccctctctc  ccgctccta  tcaacatag  gttggaagt  ctggccagg  4020
caatcaggc  ggagaagga  ataaagggt  ttcaattag  aaaagagga  gtcaaattg  4080
ccctgtttg  agacgacat  attgtatat  tagaaaacc  catcgtctc  gcccaaaat  4140
tccttaagc  gataagcaa  ttcagcaaa  tctcaggat  caaaatcaa  gtacaaaaa  4200
cacaagcat  cttatacac  aacaacaga  aaacagaga  ccaaatcat  ggtgaactc  4260
cattcgtaa  tgcttcaaa  agaataaaa  acctaggaa  ccaacttac  agggatgtg  4320
aggacctct  caaggagaa  tacaaacca  tgctcaagg  aataaaaga  gacacaaac  4380
aatggaaga  cattccatg  tcatgggta  gaagaatca  tatcgtgaa  atggccata  4440
tgcccaagg  aatttacag  ttcaatgcc  tccccatca  gctaccaat  actttcttc  4500
cagaattgg  aaaaactac  ttaaagttc  tatggaacc  aaaaagagc  cgcattgcc  4560
agtcaatcc  aagccaaaa  aacaaagct  gaggcatca  actacctga  ttcaaacta  4620
actacaagg  tacagtaac  aaaacagca  ggtactggt  ccaaaacag  gatatagat  4680
aatggaaca  aacagagcc  tcagaaata  tgccgcata  ctacaacta  ctgatcttt  4740
acaaacctg  gaaaaacaa  caatgggga  aggattccc  atttaataa  tggtgctgg  4800
aaaactggc  agccatatg  agaaagctg  aactggatc  cttccttac  ccttataca  4860
aaatcaatt  aagatggat  aaagattta  acgttaaac  taaaaccat  aaaacccta  4920
aagaaaacc  aggcattac  attcaggac  taggcgtgg  caaggactt  atgtccaaa  4980
caccaaaag  aatggcaac  aaagacaaa  ttgacaaat  ggatctaat  aaactaaag  5040
gcttctgca  agcaaaaga  actaccatc  gagtgaaca  gcaacctac  acatgggag  5100
aaattttcg  aacctactc  tctgacaaa  ggctaatat  cagaatcta  aatgaactc  5160
aacaaattt  caagaaaaa  acaaacaac  ccatcaaaa  gtgggcgaa  gacatgaac  5220
gacacttct  aaaagaaga  atttatgca  ccaaaaaac  catgaagaa  tgctcatca  5280
cactggcca  cagagaaat  caaatcaaa  ccactatga  atatcatct  acaccagtt  5340
gaatggcaa  cattaaaaa  tcaggaaac  acaggtgct  gagaggatg  ggagaaata  5400
gaacacttt  acactgttg  tgggactgt  aactagttc  accattgtg  aagtcagtg  5460
ggcgattcc  cagggatct  gaactagaa  taccatttg  cccagccat  ccattactg  5520
gtatatacc  aaatgagta  aaatcatgc  gctataaag  cacatgcac  cgtatgttt  5580
ttgcggcac  attcacaat  gcaaagact  ggaaccaac  gaaatgtcc  acaatgata  5640
actggatta  gaaaatgtg  cacatatac  ccatggaat  ctatgcagc  ataaaaaat  5700
atgagttca  atcctttgt  gggacatgg  tgaaattgg  aaccatcat  ctcagtaaa  5760
tatcgcaag  acaaaaaac  aaacaccgc  tattctcac  cataggtgg  aattgaaca  5820
tgagatcac  tggacacag  aaggggaat  tcacactct  gggactgtg  tggggtcgg  5880
ggagggggg  gggatagca  tgggagata  acctaatgc  agatgacac  ttagtgggt  5940
cagcgcacc  gcatggcac  tgtatacat  tgtaactaa  ctgcacaat  tgcacatgt  6000
ccctaaaac  tagagtata  taaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  6060
aaaaaaaaa  aaaaa  6075



<210> 8997
<211> 1275
<212> PRT
<213> Homo sapiens
<308> AAA51622
<400> 8997

Met Thr Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Asn Ile Asn 
  1               5                  10                  15
Gly Leu Asn Ser Ala Ile Lys Arg His Arg Leu Ala Ser Trp Ile Lys 
             20                  25                  30
Ser Gln Asp Pro Ser Val Cys Cys Ile Gln Glu Thr His Leu Thr Cys 
         35                  40                  45
Arg Asp Thr His Arg Leu Lys Ile Lys Gly Trp Arg Lys Ile Tyr Gln 
     50                  55                  60
Ala Asn Gly Lys Gln Lys Lys Ala Gly Val Ala Ile Leu Val Ser Asp 
 65                  70                  75                  80
Lys Thr Asp Phe Lys Pro Thr Lys Ile Lys Arg Asp Lys Glu Gly His 
                 85                  90                  95
Tyr Ile Met Val Lys Gly Ser Ile Gln Gln Glu Glu Leu Thr Ile Leu 
             100                105                110
Asn Ile Tyr Ala Pro Asn Thr Gly Ala Pro Arg Phe Ile Lys Gln Val 
         115                120                125
Leu Ser Asp Leu Gln Arg Asp Leu Asp Ser His Thr Leu Ile Met Gly 
     130                135                140
Asp Phe Asn Thr Pro Leu Ser Thr Leu Asp Arg Ser Thr Arg Gln Lys 
 145                150                155                160
Val Asn Lys Asp Thr Gln Glu Leu Asn Ser Ala Leu His Gln Ala Asp 
                 165                170                175
Leu Ile Asp Ile Tyr Arg Thr Leu His Pro Lys Ser Thr Glu Tyr Thr 
             180                185                190
Phe Phe Ser Ala Pro His His Thr Tyr Ser Lys Ile Asp His Ile Val 
         195                200                205
Gly Ser Lys Ala Leu Leu Ser Lys Cys Lys Arg Thr Glu Ile Ile Thr 
     210                215                220
Asn Tyr Leu Ser Asp His Ser Ala Ile Lys Leu Glu Leu Arg Ile Lys 
 225                230                235                240
Asn Leu Thr Gln Ser Arg Ser Thr Thr Trp Lys Leu Asn Asn Leu Leu 
                 245                250                255
Leu Asn Asp Tyr Trp Val His Asn Glu Met Lys Ala Glu Ile Lys Met 
             260                265                270
Phe Phe Glu Thr Asn Glu Asn Lys Asp Thr Thr Tyr Gln Asn Leu Trp 
         275                280                285
Asp Ala Phe Lys Ala Val Cys Arg Gly Lys Phe Ile Ala Leu Asn Ala 
     290                295                300
Tyr Lys Arg Lys Gln Glu Arg Ser Lys Ile Asp Thr Leu Thr Ser Gln 
 305                310                315                320
Leu Lys Glu Leu Glu Lys Gln Glu Gln Thr His Ser Lys Ala Ser Arg 
                 325                330                335
Arg Gln Glu Ile Thr Lys Ile Arg Ala Glu Leu Lys Glu Ile Glu Thr 
             340                345                350
Gln Lys Thr Leu Gln Lys Ile Asn Glu Ser Arg Ser Trp Phe Phe Glu 
         355                360                365
Arg Ile Asn Lys Ile Asp Arg Pro Leu Ser Arg Leu Ile Lys Lys Lys 
     370                375                380
Arg Glu Lys Asn Gln Ile Asp Thr Ile Lys Asn Asp Lys Gly Asp Ile 
 385                390                395                400
Thr Thr Asp Pro Thr Glu Ile Gln Thr Thr Ile Arg Glu Tyr Tyr Lys 
                 405                410                415
His Leu Tyr Ala Asn Lys Leu Glu Asn Leu Glu Glu Met Asp Thr Phe 
             420                425                430
Leu Asp Thr Tyr Thr Leu Pro Arg Leu Asn Gln Glu Glu Val Glu Ser 
         435                440                445
Leu Asn Arg Pro Ile Thr Gly Ser Glu Ile Val Ala Ile Ile Asn Ser 
     450                455                460
Leu Pro Thr Lys Lys Ser Pro Gly Pro Asp Gly Phe Thr Ala Glu Phe 
 465                470                475                480
Tyr Gln Arg Tyr Met Glu Glu Leu Val Pro Phe Leu Leu Lys Leu Phe 
                 485                490                495
Gln Ser Ile Glu Lys Glu Gly Ile Leu Pro Asn Ser Phe Tyr Glu Ala 
             500                505                510
Ser Ile Ile Leu Ile Pro Lys Pro Gly Arg Asp Thr Thr Lys Lys Glu 
         515                520                525
Asn Phe Arg Pro Ile Ser Leu Met Asn Ile Asp Ala Lys Ile Leu Asn 
     530                535                540
Lys Ile Leu Ala Asn Arg Ile Gln Gln His Ile Lys Lys Leu Ile His 
 545                550                555                560
His Asp Gln Val Gly Phe Ile Pro Gly Met Gln Gly Trp Phe Asn Ile 
                 565                570                575
Arg Lys Ser Ile Asn Val Ile Gln His Ile Asn Arg Ala Asn Asp Lys 
             580                585                590
Asn His Met Ile Ile Ser Ile Asp Ala Glu Lys Ala Phe Asp Lys Ile 
         595                600                605
Gln Gln Pro Phe Met Leu Lys Thr Leu Asn Lys Leu Gly Ile Asp Gly 
     610                615                620
Thr Tyr Phe Lys Ile Ile Arg Ala Ile Tyr Asp Lys Pro Thr Ala Asn 
 625                630                635                640
Ile Ile Leu Asn Gly Gln Lys Leu Glu Ala Phe Pro Leu Lys Thr Gly 
                 645                650                655
Thr Arg Gln Gly Cys Pro Leu Ser Pro Leu Leu Phe Asn Ile Val Leu 
             660                665                670
Glu Val Leu Ala Arg Ala Ile Arg Gln Glu Lys Glu Ile Lys Gly Ile 
         675                680                685
Gln Leu Gly Lys Glu Glu Val Lys Leu Ser Leu Phe Ala Asp Asp Met 
     690                695                700
Ile Val Tyr Leu Glu Asn Pro Ile Val Ser Ala Gln Asn Leu Leu Lys 
 705                710                715                720
Leu Ile Ser Asn Phe Ser Lys Val Ser Gly Tyr Lys Ile Asn Val Gln 
                 725                730                735
Lys Ser Gln Ala Phe Leu Tyr Thr Asn Asn Arg Gln Thr Glu Ser Gln 
             740                745                750
Ile Met Gly Glu Leu Pro Phe Val Ile Ala Ser Lys Arg Ile Lys Tyr 
         755                760                765
Leu Gly Ile Gln Leu Thr Arg Asp Val Lys Asp Leu Phe Lys Glu Asn 
     770                775                780
Tyr Lys Pro Leu Leu Lys Glu Ile Lys Glu Asp Thr Asn Lys Trp Lys 
 785                790                795                800
Asn Ile Pro Cys Ser Trp Val Gly Arg Ile Asn Ile Val Lys Met Ala 
                 805                810                815
Ile Leu Pro Lys Val Ile Tyr Arg Phe Asn Ala Ile Pro Ile Lys Leu 
             820                825                830
Pro Met Thr Phe Phe Thr Glu Leu Glu Lys Thr Thr Leu Lys Phe Ile 
         835                840                845
Trp Asn Gln Lys Arg Ala Arg Ile Ala Lys Ser Ile Leu Ser Gln Lys 
     850                855                860
Asn Lys Ala Gly Gly Ile Thr Leu Pro Asp Phe Lys Leu Tyr Tyr Lys 
 865                870                875                880
Ala Thr Val Thr Lys Thr Ala Trp Tyr Trp Tyr Gln Asn Arg Asp Ile 
                 885                890                895
Asp Gln Trp Asn Arg Thr Glu Pro Ser Glu Ile Met Pro His Ile Tyr 
             900                905                910
Asn Tyr Leu Ile Phe Asp Lys Pro Glu Lys Asn Lys Gln Trp Gly Lys 
         915                920                925
Asp Ser Leu Phe Asn Lys Trp Cys Trp Glu Asn Trp Leu Ala Ile Cys 
     930                935                940
Arg Lys Leu Lys Leu Asp Pro Phe Leu Thr Pro Tyr Thr Lys Ile Asn 
 945                950                955                960
Ser Arg Trp Ile Lys Asp Leu Asn Val Lys Pro Lys Thr Ile Lys Thr 
                 965                970                975
Leu Glu Glu Asn Leu Gly Ile Thr Ile Gln Asp Ile Gly Val Gly Lys 
             980                985                990
Asp Phe Met Ser Lys Thr Pro Lys Ala Met Ala Thr Lys Asp Lys Ile 
         995                1000                1005
Asp Lys Trp Asp Leu Ile Lys Leu Lys Ser Phe Cys Thr Ala Lys Glu 
     1010                1015                1020
Thr Thr Ile Arg Val Asn Arg Gln Pro Thr Thr Trp Glu Lys Ile Phe 
 1025                1030                1035                1040
Ala Thr Tyr Ser Ser Asp Lys Gly Leu Ile Ser Arg Ile Tyr Asn Glu 
                 1045                1050                1055
Leu Lys Gln Ile Tyr Lys Lys Lys Thr Asn Asn Pro Ile Lys Lys Trp 
             1060                1065                1070
Ala Lys Asp Met Asn Arg His Phe Ser Lys Glu Asp Ile Tyr Ala Ala 
         1075                1080                1085
Lys Lys His Met Lys Lys Cys Ser Ser Ser Leu Ala Ile Arg Glu Met 
     1090                1095                1100
Gln Ile Lys Thr Thr Met Arg Tyr His Leu Thr Pro Val Arg Met Ala 
 1105                1110                1115                1120
Ile Ile Lys Lys Ser Gly Asn Asn Arg Cys Trp Arg Gly Cys Gly Glu 
                 1125                1130                1135
Ile Gly Thr Leu Leu His Cys Trp Trp Asp Cys Lys Leu Val Gln Pro 
             1140                1145                1150
Leu Trp Lys Ser Val Trp Arg Phe Leu Arg Asp Leu Glu Leu Glu Ile 
         1155                1160                1165
Pro Phe Asp Pro Ala Ile Pro Leu Leu Gly Ile Tyr Pro Asn Glu Tyr 
     1170                1175                1180
Lys Ser Cys Cys Tyr Lys Asp Thr Cys Thr Arg Met Phe Ile Ala Ala 
 1185                1190                1195                1200
Leu Phe Thr Ile Ala Lys Thr Trp Asn Gln Pro Lys Cys Pro Thr Met 
                 1205                1210                1215
Ile Asp Trp Ile Lys Lys Met Trp His Ile Tyr Thr Met Glu Tyr Tyr 
             1220                1225                1230
Ala Ala Ile Lys Asn Asp Glu Phe Ile Ser Phe Val Gly Thr Trp Met 
         1235                1240                1245
Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu Ser Gln Glu Gln Lys Thr 
     1250                1255                1260
Lys His Arg Ile Phe Ser Leu Ile Gly Gly Asn 
 1265                1270                1275



<210> 8998
<211> 3166
<212> DNA
<213> Rattus norvegicus
<308> U83883
<400> 8998

ccgtgcaac  gggcatcgt  aagatggtc  tctctgggt  tgccatgat  gtccgaggg  60
tgccccgtg  taccgctcc  gagaggcag  tcaacctca  caacattcg  gctggaaat  120
tcgacacac  tcgtcgagc  gctacacaa  cagatggga  agatacccc  gatgagccc  180
gggcatttc  tgctagaga  ttccttcgc  agaagctga  tgggaagga  gtctgtttc  240
cgatagaaa  caagactcc  caaggacga  agtatggaa  gatctacct  ggaaaagat  300
ctaatgggg  aaacattgc  gagtcgcta  tcgcagaag  cttggctcc  ggagagagc  360
tgagagcca  taatccaga  cagaaccgg  tttcagaat  cgaggaaca  gcaaaggca  420
cgaagaaag  gatgtggag  gaggggacg  gtcacacac  tccggacct  aagtacacc  480
ttgagaacc  aaggcactt  gtggactca  accaccaga  gcctgtcaa  gctatcatt  540
agcatgttc  agacggcag  gtggtccgg  ccctgctcc  tccggatca  taccttgtt  600
ccgtcatgc  gtcagggat  aagtgccca  cctttcgtc  agaaacaga  ggtagtgaa  660
caccagagc  cttcgctgc  gaagccaag  ttttcacgg  gtctcgact  cttcagaga  720
atgttcaga  cattctgga  agctgccat  atcagaaca  tctgggcac  atccttcat  780
caaatggta  catcactga  ctcctcctg  aggaaggtt  tgcccgctg  gtggactgg  840
caattgcag  ttacacccg  ggtgcagaa  agctgaggg  agctgagag  tttgccaag  900
agcgtaggc  gagaatatg  agagactat  tgcctccta  tgctaattt  gaccaaaag  960
acaagcagt  tgttgccaa  gtaatgcag  ttttgaatg  tgatgccat  gttgtgaag  1020
tgagttctg  agactacaa  accatccac  tgtcaagca  ccgaccacc  aggttggag  1080
gagacaaca  acaggataa  aataagaag  tgcgtcccc  gtatgacat  ccctacatg  1140
ttgaggccc  ggaattcct  cgcaaaaag  tgattggga  gaaggtcag  gtgactgtg  1200
actacatta  accagccag  ccagccaca  aaacagtgc  tgccttttc  gagcgtacc  1260
gtgccacag  caccattgg  ggaataaac  ttactgagg  ccttgtcag  aaaggccta  1320
ccacagtga  cagataccg  caggatgat  accagagat  ttcacacta  gatgagctg  1380
tggctgcag  ggccagagc  attaagaat  gcaaaggat  gcacagcaa  aaggaagtg  1440
ccatccacc  agttgcaga  atttctggg  acacccaga  agcaaagca  ttcctgccc  1500
ttcttcagc  cgcaggccg  tctgaggct  tggtggagt  tgtcttcag  ggctctcgc  1560
tcaagctct  cttacctaa  gagacctgt  tcatcacct  cctgctggc  ggcattgaa  1620
gtcccagag  agcacgaaa  ctcccaggc  tggtgcagg  aggagagcc  ttcagtgag  1680
aagccacac  tttcaccaa  gaactagtg  tgcagcgag  ggtggaggt  gaggtagag  1740
gcatggata  ggctggcaa  ttcattggc  ggctacaca  ggatggggc  aacctgtct  1800
tcttgctgg  ggagcacgc  ctctccaag  tccacttca  tgctgagcg  agcggctac  1860
ataagcctc  cctgtctgc  gaggaagct  ccaagcaga  gaaagagaa  gtctgggcc  1920
actatgagg  gcagcctgt  gaggaggta  tgcctgtac  ggaagagaa  gagcgctcg  1980
ccagctaca  gccagtgtt  gtgaccgag  tcacagatg  cctgcattt  tatgtgcaa  2040
atgtggaga  tggcaccca  ctggaaaaa  tgatggaga  catgcgcag  gacatctcc  2100
gccaccctc  tgttgaggg  ctacgccca  gccggggag  gttctgcat  gccaaattt  2160
tagatggag  atggtaccg  gcccgggta  aaaaagagg  gtcccctgc  aaagtgcat  2220
tcttctaca  cgactatgg  aatagagag  tcctgccat  cacccgcct  gccctacca  2280
ctgccttca  cactcgcgt  ttgccagct  aagccacag  gtatgcctt  gccttcatc  2340
agtggcccc  agatgagga  gctcgcaca  atgctgtga  agtgtgtgc  gacatccaa  2400
acactcagt  cctgctcaa  gtggagcac  tgagtgcca  ctgccccca  gtcactctg  2460
agtttgcgg  ttccaaagg  gatgtgggg  tgggcctgg  gaaggaagg  ctcgtcatg  2520
tagaagttc  gaaggagaa  cagttccag  aagtgatca  agagtacct  aatgcccag  2580
aatcagcca  gagtgccag  ctgaacctg  ggcgctatg  cgacttccg  gctgacgat  2640
ctgatgagt  tggctacag  cgctaagga  aacttgcct  gctcccagc  ccgatgatg  2700
cagaccttc  ccctctgcc  ggaagccgt  ttcaactcc  gacctggtc  ggggagtat  2760
gattgggtc  agcttgctt  agacagaaa  ctcctctgt  gcgggtagc  ttggagctg  2820
ggtggagag  ccaaggctt  ctggggcag  cccctcagt  gtactgccg  ccagtctct  2880
ccagatgat  ttgtatttt  atttaattg  cttcaaatc  ggaaagaac  atgaaagac  2940
gtgtgttag  gaagggtat  atcgtgaca  agaggcagc  gtcagctgg  acccacctc  3000
cccccagac  acccttctt  ccaagctct  tccaagtgt  gattatgtg  cttctgata  3060
atccgttct  aaattccag  gtgcccata  ctgccccca  accagcctg  tctgtattt  3120
aagcttttg  gacccaata  aatagtacc  gctgtctgc  aaaaaa  3166



<210> 8999
<211> 880
<212> PRT
<213> Rattus norvegicus
<308> AAB41439
<400> 8999

Met Val Leu Ser Gly Cys Ala Met Ile Val Arg Gly Leu Pro Arg Gly 
  1               5                  10                  15
Thr Ala Pro Glu Arg Gln Ile Asn Leu Ser Asn Ile Arg Ala Gly Asn 
             20                  25                  30
Leu Asp Thr Arg Arg Arg Ala Ala Thr Gln Pro Asp Gly Lys Asp Thr 
         35                  40                  45
Pro Asp Glu Pro Trp Ala Phe Pro Ala Arg Glu Phe Leu Arg Lys Lys 
     50                  55                  60
Leu Ile Gly Lys Glu Val Cys Phe Thr Ile Glu Asn Lys Thr Pro Gln 
 65                  70                  75                  80
Gly Arg Glu Tyr Gly Met Ile Tyr Leu Gly Lys Asp Thr Asn Gly Glu 
                 85                  90                  95
Asn Ile Ala Glu Ser Leu Val Ala Glu Gly Leu Ala Pro Gly Glu Ser 
             100                105                110
Met Arg Ala Asn Asn Pro Glu Gln Asn Arg Leu Ser Glu Cys Glu Glu 
         115                120                125
Gln Ala Lys Ala Ser Lys Lys Gly Met Trp Ser Glu Gly Thr Gly His 
     130                135                140
Thr His Pro Asp Leu Lys Tyr Thr Ile Glu Asn Pro Arg His Phe Val 
 145                150                155                160
Asp Ser His His Gln Lys Pro Val Asn Ala Ile Ile Glu His Val Arg 
                 165                170                175
Asp Gly Ser Val Val Arg Ala Leu Leu Leu Pro Asp His Tyr Leu Val 
             180                185                190
Thr Val Met Leu Ser Gly Ile Lys Cys Pro Thr Phe Arg Arg Glu Thr 
         195                200                205
Asp Gly Ser Glu Thr Pro Glu Pro Phe Ala Ala Glu Ala Lys Phe Phe 
     210                215                220
Thr Glu Ser Arg Leu Leu Gln Arg Asp Val Gln Ile Ile Leu Glu Ser 
 225                230                235                240
Cys His Asn Gln Asn Ile Leu Gly Thr Ile Leu His Pro Asn Gly Asn 
                 245                250                255
Ile Thr Glu Leu Leu Leu Lys Glu Gly Phe Ala Arg Cys Val Asp Trp 
             260                265                270
Ser Ile Ala Val Tyr Thr Arg Gly Ala Glu Lys Leu Arg Ala Ala Glu 
         275                280                285
Arg Phe Ala Lys Glu Arg Arg Leu Arg Ile Trp Arg Asp Tyr Val Pro 
     290                295                300
Pro Thr Ala Asn Leu Asp Gln Lys Asp Lys Gln Phe Val Ala Lys Val 
 305                310                315                320
Met Gln Val Leu Asn Ala Asp Ala Ile Val Val Lys Leu Ser Ser Gly 
                 325                330                335
Asp Tyr Lys Thr Ile His Leu Ser Ser Ile Arg Pro Pro Arg Leu Glu 
             340                345                350
Gly Asp Asn Ile Gln Asp Lys Asn Lys Lys Leu Arg Pro Leu Tyr Asp 
         355                360                365
Ile Pro Tyr Met Phe Glu Ala Arg Glu Phe Leu Arg Lys Lys Leu Ile 
     370                375                380
Gly Lys Lys Val Ser Val Thr Val Asp Tyr Ile Arg Pro Ala Ser Pro 
 385                390                395                400
Ala Thr Glu Thr Val Pro Ala Phe Ser Glu Arg Thr Cys Ala Thr Val 
                 405                410                415
Thr Ile Gly Gly Ile Asn Ile Thr Glu Ala Leu Val Ser Lys Gly Leu 
             420                425                430
Ala Thr Val Ile Arg Tyr Arg Gln Asp Asp Asp Gln Arg Ser Ser His 
         435                440                445
Tyr Asp Glu Leu Leu Ala Ala Glu Ala Arg Ala Ile Lys Asn Gly Lys 
     450                455                460
Gly Leu His Ser Lys Lys Glu Val Pro Ile His Arg Val Ala Asp Ile 
 465                470                475                480
Ser Gly Asp Thr Gln Lys Ala Lys Gln Phe Leu Pro Phe Leu Gln Arg 
                 485                490                495
Ala Gly Arg Ser Glu Ala Val Val Glu Tyr Val Phe Ser Gly Ser Arg 
             500                505                510
Leu Lys Leu Tyr Leu Pro Lys Glu Thr Cys Leu Ile Thr Phe Leu Leu 
         515                520                525
Ala Gly Ile Glu Cys Pro Arg Gly Ala Arg Asn Leu Pro Gly Leu Val 
     530                535                540
Gln Glu Gly Glu Pro Phe Ser Glu Glu Ala Thr Leu Phe Thr Lys Glu 
 545                550                555                560
Leu Val Leu Gln Arg Glu Val Glu Val Glu Val Glu Ser Met Asp Lys 
                 565                570                575
Ala Gly Asn Phe Ile Gly Trp Leu His Met Asp Gly Ala Asn Leu Ser 
             580                585                590
Val Leu Leu Val Glu His Ala Leu Ser Lys Val His Phe Thr Ala Glu 
         595                600                605
Arg Ser Gly Tyr Tyr Lys Pro Leu Leu Ser Ala Glu Glu Ala Ala Lys 
     610                615                620
Gln Arg Lys Glu Lys Val Trp Ala His Tyr Glu Glu Gln Pro Val Glu 
 625                630                635                640
Glu Val Met Pro Val Leu Glu Glu Lys Glu Arg Ser Ala Ser Tyr Lys 
                 645                650                655
Pro Val Phe Val Thr Glu Ile Thr Asp Asp Leu His Phe Tyr Val Gln 
             660                665                670
Asp Val Glu Thr Gly Thr Gln Leu Glu Lys Leu Met Glu Asn Met Arg 
         675                680                685
Ser Asp Ile Ser Ser His Pro Pro Val Glu Gly Leu Arg Pro Arg Arg 
     690                695                700
Gly Glu Phe Cys Ile Ala Lys Phe Val Asp Gly Glu Trp Tyr Arg Ala 
 705                710                715                720
Arg Val Glu Lys Glu Glu Ser Pro Ala Lys Val His Val Phe Tyr Ile 
                 725                730                735
Asp Tyr Gly Asn Arg Glu Ile Leu Pro Ser Thr Arg Leu Ala Leu Pro 
             740                745                750
Pro Ala Phe Ser Thr Arg Val Leu Pro Ala Gln Ala Thr Glu Tyr Ala 
         755                760                765
Phe Ala Phe Ile Gln Trp Pro Gln Asp Glu Asp Ala Arg Thr Asp Ala 
     770                775                780
Val Thr Val Cys Ala Asp Ile Gln Asn Thr Gln Cys Leu Leu Asn Val 
 785                790                795                800
Glu His Leu Ser Ala Ser Cys Pro His Val Thr Leu Gln Phe Ala Asp 
                 805                810                815
Ser Lys Gly Asp Val Gly Leu Gly Leu Val Lys Glu Gly Leu Val Met 
             820                825                830
Val Glu Val Arg Lys Glu Lys Gln Phe Gln Lys Val Ile Thr Glu Tyr 
         835                840                845
Leu Asn Ala Gln Glu Ser Ala Lys Ser Ala Arg Leu Asn Leu Trp Arg 
     850                855                860
Tyr Gly Asp Phe Arg Ala Asp Asp Ala Asp Glu Phe Gly Tyr Ser Arg 
 865                870                875                880



<210> 9000
<211> 714
<212> DNA
<213> Homo sapiens
<308> BG542891
<400> 9000

gaggctctt  tcagcaaag  tctagccac  gtgatcaga  accggcagg  tgatgacca  60
agatcatca  actacgatg  actgcttgc  gcagaggcc  gagctatta  gaatggcaa  120
ggattgcat  gcaagaagg  agtgcctat  caccgtgtt  cagatatat  tggggatac  180
caaaaagca  agcagttcc  gccttttct  cagcgggca  gtcgttctg  agctgtggt  240
gaatacgtc  tcagtggtt  tcgtctcaa  ctctatttg  caaaggaaa  ttgccttat  300
accttcttg  ttgcaggca  tgaatgccc  agaggagcc  gaaacctcc  aggcttggt  360
caggaagga  agcccttca  cgaggaagc  acacttttc  ccaaggaac  ggtgctgca  420
cgagaggtc  gggcccact  tgaggagca  cccgtggag  aggtgatgc  agtgctgga  480
gagaaggag  gatctgcta  ctacaagcc  gtgtttgtg  ccgagatca  tgatgacct  540
cacttctac  tgcaggatg  ggagaccgg  acccagttg  agaagctga  ggagaacat  600
cgcaatgac  ttgccagtc  cccccctgt  gagggctcc  tatgccccc  gcaggggag  660
gttctgatt  caaatttgt  gatggagaa  ggtaccgtg  ccgagtaga  aaag  714



<210> 9001
<211> 914
<212> PRT
<213> Homo sapiens
<308> XP_011618
<400> 9001

Met Ala Ser Ser Ala Gln Ser Gly Gly Ser Ser Gly Gly Pro Ala Val 
  1               5                  10                  15
Pro Thr Val Gln Arg Gly Ile Ile Lys Met Val Leu Ser Gly Cys Ala 
             20                  25                  30
Ile Ile Val Arg Gly Gln Pro Arg Gly Gly Pro Pro Pro Glu Arg Gln 
         35                  40                  45
Ile Asn Leu Ser Asn Ile Arg Ala Gly Asn Leu Ala Arg Arg Ala Ala 
     50                  55                  60
Ala Thr Gln Pro Asp Ala Lys Asp Thr Pro Asp Glu Pro Trp Ala Phe 
 65                  70                  75                  80
Pro Ala Arg Glu Phe Leu Arg Lys Lys Leu Ile Gly Lys Glu Val Cys 
                 85                  90                  95
Phe Thr Ile Glu Asn Lys Thr Pro Gln Gly Arg Glu Tyr Gly Met Ile 
             100                105                110
Tyr Leu Gly Lys Asp Thr Asn Gly Glu Asn Ile Ala Glu Ser Leu Val 
         115                120                125
Ala Glu Gly Leu Ala Thr Arg Arg Glu Gly Met Arg Ala Asn Asn Pro 
     130                135                140
Glu Gln Asn Arg Leu Ser Glu Cys Glu Glu Gln Ala Lys Ala Ala Lys 
 145                150                155                160
Lys Gly Met Trp Ser Glu Gly Asn Gly Ser His Thr Ile Arg Asp Leu 
                 165                170                175
Lys Tyr Thr Ile Glu Asn Pro Arg His Phe Val Asp Ser His His Gln 
             180                185                190
Lys Pro Val Asn Ala Ile Ile Glu His Val Arg Asp Gly Ser Val Val 
         195                200                205
Arg Ala Leu Leu Leu Pro Asp Tyr Tyr Leu Val Thr Val Met Leu Ser 
     210                215                220
Gly Ile Lys Cys Pro Thr Phe Arg Arg Glu Ala Asp Gly Ser Glu Thr 
 225                230                235                240
Pro Glu Pro Phe Ala Ala Glu Ala Lys Phe Phe Thr Glu Ser Arg Leu 
                 245                250                255
Leu Gln Arg Asp Val Gln Ile Ile Leu Glu Ser Cys His Asn Gln Asn 
             260                265                270
Ile Leu Gly Thr Ile Leu His Pro Asn Gly Asn Ile Thr Glu Leu Leu 
         275                280                285
Leu Lys Glu Gly Phe Ala Arg Cys Val Asp Trp Ser Ile Ala Val Tyr 
     290                295                300
Thr Arg Gly Ala Glu Lys Leu Arg Ala Ala Glu Arg Phe Ala Lys Glu 
 305                310                315                320
Arg Arg Leu Arg Ile Trp Arg Asp Tyr Val Ala Pro Thr Ala Asn Leu 
                 325                330                335
Asp Gln Lys Asp Lys Gln Phe Val Ala Lys Val Met Gln Val Leu Asn 
             340                345                350
Ala Asp Ala Ile Val Val Lys Leu Asn Ser Gly Asp Tyr Lys Thr Ile 
         355                360                365
His Leu Ser Ser Ile Arg Pro Pro Arg Leu Glu Gly Glu Asn Thr Gln 
     370                375                380
Asp Lys Asn Lys Lys Leu Arg Pro Leu Tyr Asp Ile Pro Tyr Met Phe 
 385                390                395                400
Glu Ala Arg Glu Phe Leu Arg Lys Lys Leu Ile Gly Lys Lys Val Asn 
                 405                410                415
Val Thr Val Asp Tyr Ile Arg Pro Ala Ser Pro Ala Thr Glu Thr Val 
             420                425                430
Pro Ala Phe Ser Glu Arg Thr Cys Ala Thr Val Thr Ile Gly Gly Ile 
         435                440                445
Asn Ile Ala Glu Ala Leu Val Ser Lys Gly Leu Ala Thr Val Ile Arg 
     450                455                460
Tyr Arg Gln Asp Asp Asp Gln Arg Ser Ser His Tyr Asp Glu Leu Leu 
 465                470                475                480
Ala Ala Glu Ala Arg Ala Ile Lys Asn Gly Lys Gly Leu His Ser Lys 
                 485                490                495
Lys Glu Val Pro Ile His Arg Val Ala Asp Ile Ser Gly Asp Thr Gln 
             500                505                510
Lys Ala Lys Gln Phe Leu Pro Phe Leu Gln Arg Ala Gly Arg Ser Glu 
         515                520                525
Ala Val Val Glu Tyr Val Phe Ser Gly Ser Arg Leu Lys Leu Tyr Leu 
     530                535                540
Pro Lys Glu Thr Cys Leu Ile Thr Phe Leu Leu Ala Gly Ile Glu Cys 
 545                550                555                560
Pro Arg Gly Ala Arg Asn Leu Pro Gly Leu Val Gln Glu Gly Glu Pro 
                 565                570                575
Phe Ser Glu Glu Ala Thr Leu Phe Thr Lys Glu Leu Val Leu Gln Arg 
             580                585                590
Glu Val Glu Val Glu Val Glu Ser Met Asp Lys Ala Gly Asn Phe Ile 
         595                600                605
Gly Trp Leu His Ile Asp Gly Ala Asn Leu Ser Val Leu Leu Val Glu 
     610                615                620
His Ala Leu Ser Lys Val His Phe Thr Ala Glu Arg Ser Ser Tyr Tyr 
 625                630                635                640
Lys Ser Leu Leu Ser Ala Glu Glu Ala Ala Lys Gln Lys Lys Glu Lys 
                 645                650                655
Val Trp Ala His Tyr Glu Glu Gln Pro Val Glu Glu Val Met Pro Val 
             660                665                670
Leu Glu Glu Lys Glu Arg Ser Ala Ser Tyr Lys Pro Val Phe Val Thr 
         675                680                685
Glu Ile Thr Asp Asp Leu His Phe Tyr Val Gln Asp Val Glu Thr Gly 
     690                695                700
Thr Gln Leu Glu Lys Leu Met Glu Asn Met Arg Asn Asp Ile Ala Ser 
 705                710                715                720
His Pro Pro Val Glu Gly Ser Tyr Ala Pro Arg Arg Gly Glu Phe Cys 
                 725                730                735
Ile Ala Lys Phe Val Asp Gly Glu Trp Tyr Arg Ala Arg Val Glu Lys 
             740                745                750
Val Glu Ser Pro Ala Lys Ile His Val Phe Tyr Ile Asp Tyr Gly Asn 
         755                760                765
Arg Glu Val Leu Pro Ser Thr Arg Leu Gly Thr Leu Ser Pro Ala Phe 
     770                775                780
Ser Thr Arg Val Leu Pro Ala Gln Ala Thr Glu Tyr Ala Phe Ala Phe 
 785                790                795                800
Ile Gln Val Pro Gln Asp Asp Asp Ala Arg Thr Asp Ala Val Asp Ser 
                 805                810                815
Val Val Arg Asp Ile Gln Asn Thr Gln Cys Leu Leu Asn Val Glu His 
             820                825                830
Leu Ser Ala Gly Cys Pro His Val Thr Leu Gln Phe Ala Asp Ser Lys 
         835                840                845
Gly Asp Val Gly Leu Gly Leu Val Lys Glu Gly Leu Val Met Val Glu 
     850                855                860
Val Arg Lys Glu Lys Gln Phe Gln Lys Val Ile Thr Glu Tyr Leu Asn 
 865                870                875                880
Ala Gln Glu Ser Ala Lys Ser Ala Arg Leu Asn Leu Trp Arg Tyr Gly 
                 885                890                895
Asp Phe Arg Ala Asp Asp Ala Asp Cys Pro Arg Pro Ser Ser Leu Ser 
             900                905                910
Asn Cys 
         915



<210> 9002
<211> 3166
<212> DNA
<213> Rattus norvegicus
<308> U83883
<400> 9002

ccgtgcaac  gggcatcgt  aagatggtc  tctctgggt  tgccatgat  gtccgaggg  60
tgccccgtg  taccgctcc  gagaggcag  tcaacctca  caacattcg  gctggaaat  120
tcgacacac  tcgtcgagc  gctacacaa  cagatggga  agatacccc  gatgagccc  180
gggcatttc  tgctagaga  ttccttcgc  agaagctga  tgggaagga  gtctgtttc  240
cgatagaaa  caagactcc  caaggacga  agtatggaa  gatctacct  ggaaaagat  300
ctaatgggg  aaacattgc  gagtcgcta  tcgcagaag  cttggctcc  ggagagagc  360
tgagagcca  taatccaga  cagaaccgg  tttcagaat  cgaggaaca  gcaaaggca  420
cgaagaaag  gatgtggag  gaggggacg  gtcacacac  tccggacct  aagtacacc  480
ttgagaacc  aaggcactt  gtggactca  accaccaga  gcctgtcaa  gctatcatt  540
agcatgttc  agacggcag  gtggtccgg  ccctgctcc  tccggatca  taccttgtt  600
ccgtcatgc  gtcagggat  aagtgccca  cctttcgtc  agaaacaga  ggtagtgaa  660
caccagagc  cttcgctgc  gaagccaag  ttttcacgg  gtctcgact  cttcagaga  720
atgttcaga  cattctgga  agctgccat  atcagaaca  tctgggcac  atccttcat  780
caaatggta  catcactga  ctcctcctg  aggaaggtt  tgcccgctg  gtggactgg  840
caattgcag  ttacacccg  ggtgcagaa  agctgaggg  agctgagag  tttgccaag  900
agcgtaggc  gagaatatg  agagactat  tgcctccta  tgctaattt  gaccaaaag  960
acaagcagt  tgttgccaa  gtaatgcag  ttttgaatg  tgatgccat  gttgtgaag  1020
tgagttctg  agactacaa  accatccac  tgtcaagca  ccgaccacc  aggttggag  1080
gagacaaca  acaggataa  aataagaag  tgcgtcccc  gtatgacat  ccctacatg  1140
ttgaggccc  ggaattcct  cgcaaaaag  tgattggga  gaaggtcag  gtgactgtg  1200
actacatta  accagccag  ccagccaca  aaacagtgc  tgccttttc  gagcgtacc  1260
gtgccacag  caccattgg  ggaataaac  ttactgagg  ccttgtcag  aaaggccta  1320
ccacagtga  cagataccg  caggatgat  accagagat  ttcacacta  gatgagctg  1380
tggctgcag  ggccagagc  attaagaat  gcaaaggat  gcacagcaa  aaggaagtg  1440
ccatccacc  agttgcaga  atttctggg  acacccaga  agcaaagca  ttcctgccc  1500
ttcttcagc  cgcaggccg  tctgaggct  tggtggagt  tgtcttcag  ggctctcgc  1560
tcaagctct  cttacctaa  gagacctgt  tcatcacct  cctgctggc  ggcattgaa  1620
gtcccagag  agcacgaaa  ctcccaggc  tggtgcagg  aggagagcc  ttcagtgag  1680
aagccacac  tttcaccaa  gaactagtg  tgcagcgag  ggtggaggt  gaggtagag  1740
gcatggata  ggctggcaa  ttcattggc  ggctacaca  ggatggggc  aacctgtct  1800
tcttgctgg  ggagcacgc  ctctccaag  tccacttca  tgctgagcg  agcggctac  1860
ataagcctc  cctgtctgc  gaggaagct  ccaagcaga  gaaagagaa  gtctgggcc  1920
actatgagg  gcagcctgt  gaggaggta  tgcctgtac  ggaagagaa  gagcgctcg  1980
ccagctaca  gccagtgtt  gtgaccgag  tcacagatg  cctgcattt  tatgtgcaa  2040
atgtggaga  tggcaccca  ctggaaaaa  tgatggaga  catgcgcag  gacatctcc  2100
gccaccctc  tgttgaggg  ctacgccca  gccggggag  gttctgcat  gccaaattt  2160
tagatggag  atggtaccg  gcccgggta  aaaaagagg  gtcccctgc  aaagtgcat  2220
tcttctaca  cgactatgg  aatagagag  tcctgccat  cacccgcct  gccctacca  2280
ctgccttca  cactcgcgt  ttgccagct  aagccacag  gtatgcctt  gccttcatc  2340
agtggcccc  agatgagga  gctcgcaca  atgctgtga  agtgtgtgc  gacatccaa  2400
acactcagt  cctgctcaa  gtggagcac  tgagtgcca  ctgccccca  gtcactctg  2460
agtttgcgg  ttccaaagg  gatgtgggg  tgggcctgg  gaaggaagg  ctcgtcatg  2520
tagaagttc  gaaggagaa  cagttccag  aagtgatca  agagtacct  aatgcccag  2580
aatcagcca  gagtgccag  ctgaacctg  ggcgctatg  cgacttccg  gctgacgat  2640
ctgatgagt  tggctacag  cgctaagga  aacttgcct  gctcccagc  ccgatgatg  2700
cagaccttc  ccctctgcc  ggaagccgt  ttcaactcc  gacctggtc  ggggagtat  2760
gattgggtc  agcttgctt  agacagaaa  ctcctctgt  gcgggtagc  ttggagctg  2820
ggtggagag  ccaaggctt  ctggggcag  cccctcagt  gtactgccg  ccagtctct  2880
ccagatgat  ttgtatttt  atttaattg  cttcaaatc  ggaaagaac  atgaaagac  2940
gtgtgttag  gaagggtat  atcgtgaca  agaggcagc  gtcagctgg  acccacctc  3000
cccccagac  acccttctt  ccaagctct  tccaagtgt  gattatgtg  cttctgata  3060
atccgttct  aaattccag  gtgcccata  ctgccccca  accagcctg  tctgtattt  3120
aagcttttg  gacccaata  aatagtacc  gctgtctgc  aaaaaa  3166



<210> 9003
<211> 880
<212> PRT
<213> Rattus norvegicus
<308> AAB41439
<400> 9003

Met Val Leu Ser Gly Cys Ala Met Ile Val Arg Gly Leu Pro Arg Gly 
  1               5                  10                  15
Thr Ala Pro Glu Arg Gln Ile Asn Leu Ser Asn Ile Arg Ala Gly Asn 
             20                  25                  30
Leu Asp Thr Arg Arg Arg Ala Ala Thr Gln Pro Asp Gly Lys Asp Thr 
         35                  40                  45
Pro Asp Glu Pro Trp Ala Phe Pro Ala Arg Glu Phe Leu Arg Lys Lys 
     50                  55                  60
Leu Ile Gly Lys Glu Val Cys Phe Thr Ile Glu Asn Lys Thr Pro Gln 
 65                  70                  75                  80
Gly Arg Glu Tyr Gly Met Ile Tyr Leu Gly Lys Asp Thr Asn Gly Glu 
                 85                  90                  95
Asn Ile Ala Glu Ser Leu Val Ala Glu Gly Leu Ala Pro Gly Glu Ser 
             100                105                110
Met Arg Ala Asn Asn Pro Glu Gln Asn Arg Leu Ser Glu Cys Glu Glu 
         115                120                125
Gln Ala Lys Ala Ser Lys Lys Gly Met Trp Ser Glu Gly Thr Gly His 
     130                135                140
Thr His Pro Asp Leu Lys Tyr Thr Ile Glu Asn Pro Arg His Phe Val 
 145                150                155                160
Asp Ser His His Gln Lys Pro Val Asn Ala Ile Ile Glu His Val Arg 
                 165                170                175
Asp Gly Ser Val Val Arg Ala Leu Leu Leu Pro Asp His Tyr Leu Val 
             180                185                190
Thr Val Met Leu Ser Gly Ile Lys Cys Pro Thr Phe Arg Arg Glu Thr 
         195                200                205
Asp Gly Ser Glu Thr Pro Glu Pro Phe Ala Ala Glu Ala Lys Phe Phe 
     210                215                220
Thr Glu Ser Arg Leu Leu Gln Arg Asp Val Gln Ile Ile Leu Glu Ser 
 225                230                235                240
Cys His Asn Gln Asn Ile Leu Gly Thr Ile Leu His Pro Asn Gly Asn 
                 245                250                255
Ile Thr Glu Leu Leu Leu Lys Glu Gly Phe Ala Arg Cys Val Asp Trp 
             260                265                270
Ser Ile Ala Val Tyr Thr Arg Gly Ala Glu Lys Leu Arg Ala Ala Glu 
         275                280                285
Arg Phe Ala Lys Glu Arg Arg Leu Arg Ile Trp Arg Asp Tyr Val Pro 
     290                295                300
Pro Thr Ala Asn Leu Asp Gln Lys Asp Lys Gln Phe Val Ala Lys Val 
 305                310                315                320
Met Gln Val Leu Asn Ala Asp Ala Ile Val Val Lys Leu Ser Ser Gly 
                 325                330                335
Asp Tyr Lys Thr Ile His Leu Ser Ser Ile Arg Pro Pro Arg Leu Glu 
             340                345                350
Gly Asp Asn Ile Gln Asp Lys Asn Lys Lys Leu Arg Pro Leu Tyr Asp 
         355                360                365
Ile Pro Tyr Met Phe Glu Ala Arg Glu Phe Leu Arg Lys Lys Leu Ile 
     370                375                380
Gly Lys Lys Val Ser Val Thr Val Asp Tyr Ile Arg Pro Ala Ser Pro 
 385                390                395                400
Ala Thr Glu Thr Val Pro Ala Phe Ser Glu Arg Thr Cys Ala Thr Val 
                 405                410                415
Thr Ile Gly Gly Ile Asn Ile Thr Glu Ala Leu Val Ser Lys Gly Leu 
             420                425                430
Ala Thr Val Ile Arg Tyr Arg Gln Asp Asp Asp Gln Arg Ser Ser His 
         435                440                445
Tyr Asp Glu Leu Leu Ala Ala Glu Ala Arg Ala Ile Lys Asn Gly Lys 
     450                455                460
Gly Leu His Ser Lys Lys Glu Val Pro Ile His Arg Val Ala Asp Ile 
 465                470                475                480
Ser Gly Asp Thr Gln Lys Ala Lys Gln Phe Leu Pro Phe Leu Gln Arg 
                 485                490                495
Ala Gly Arg Ser Glu Ala Val Val Glu Tyr Val Phe Ser Gly Ser Arg 
             500                505                510
Leu Lys Leu Tyr Leu Pro Lys Glu Thr Cys Leu Ile Thr Phe Leu Leu 
         515                520                525
Ala Gly Ile Glu Cys Pro Arg Gly Ala Arg Asn Leu Pro Gly Leu Val 
     530                535                540
Gln Glu Gly Glu Pro Phe Ser Glu Glu Ala Thr Leu Phe Thr Lys Glu 
 545                550                555                560
Leu Val Leu Gln Arg Glu Val Glu Val Glu Val Glu Ser Met Asp Lys 
                 565                570                575
Ala Gly Asn Phe Ile Gly Trp Leu His Met Asp Gly Ala Asn Leu Ser 
             580                585                590
Val Leu Leu Val Glu His Ala Leu Ser Lys Val His Phe Thr Ala Glu 
         595                600                605
Arg Ser Gly Tyr Tyr Lys Pro Leu Leu Ser Ala Glu Glu Ala Ala Lys 
     610                615                620
Gln Arg Lys Glu Lys Val Trp Ala His Tyr Glu Glu Gln Pro Val Glu 
 625                630                635                640
Glu Val Met Pro Val Leu Glu Glu Lys Glu Arg Ser Ala Ser Tyr Lys 
                 645                650                655
Pro Val Phe Val Thr Glu Ile Thr Asp Asp Leu His Phe Tyr Val Gln 
             660                665                670
Asp Val Glu Thr Gly Thr Gln Leu Glu Lys Leu Met Glu Asn Met Arg 
         675                680                685
Ser Asp Ile Ser Ser His Pro Pro Val Glu Gly Leu Arg Pro Arg Arg 
     690                695                700
Gly Glu Phe Cys Ile Ala Lys Phe Val Asp Gly Glu Trp Tyr Arg Ala 
 705                710                715                720
Arg Val Glu Lys Glu Glu Ser Pro Ala Lys Val His Val Phe Tyr Ile 
                 725                730                735
Asp Tyr Gly Asn Arg Glu Ile Leu Pro Ser Thr Arg Leu Ala Leu Pro 
             740                745                750
Pro Ala Phe Ser Thr Arg Val Leu Pro Ala Gln Ala Thr Glu Tyr Ala 
         755                760                765
Phe Ala Phe Ile Gln Trp Pro Gln Asp Glu Asp Ala Arg Thr Asp Ala 
     770                775                780
Val Thr Val Cys Ala Asp Ile Gln Asn Thr Gln Cys Leu Leu Asn Val 
 785                790                795                800
Glu His Leu Ser Ala Ser Cys Pro His Val Thr Leu Gln Phe Ala Asp 
                 805                810                815
Ser Lys Gly Asp Val Gly Leu Gly Leu Val Lys Glu Gly Leu Val Met 
             820                825                830
Val Glu Val Arg Lys Glu Lys Gln Phe Gln Lys Val Ile Thr Glu Tyr 
         835                840                845
Leu Asn Ala Gln Glu Ser Ala Lys Ser Ala Arg Leu Asn Leu Trp Arg 
     850                855                860
Tyr Gly Asp Phe Arg Ala Asp Asp Ala Asp Glu Phe Gly Tyr Ser Arg 
 865                870                875                880



<210> 9004
<211> 714
<212> DNA
<213> Homo sapiens
<308> BG542891
<400> 9004

gaggctctt  tcagcaaag  tctagccac  gtgatcaga  accggcagg  tgatgacca  60
agatcatca  actacgatg  actgcttgc  gcagaggcc  gagctatta  gaatggcaa  120
ggattgcat  gcaagaagg  agtgcctat  caccgtgtt  cagatatat  tggggatac  180
caaaaagca  agcagttcc  gccttttct  cagcgggca  gtcgttctg  agctgtggt  240
gaatacgtc  tcagtggtt  tcgtctcaa  ctctatttg  caaaggaaa  ttgccttat  300
accttcttg  ttgcaggca  tgaatgccc  agaggagcc  gaaacctcc  aggcttggt  360
caggaagga  agcccttca  cgaggaagc  acacttttc  ccaaggaac  ggtgctgca  420
cgagaggtc  gggcccact  tgaggagca  cccgtggag  aggtgatgc  agtgctgga  480
gagaaggag  gatctgcta  ctacaagcc  gtgtttgtg  ccgagatca  tgatgacct  540
cacttctac  tgcaggatg  ggagaccgg  acccagttg  agaagctga  ggagaacat  600
cgcaatgac  ttgccagtc  cccccctgt  gagggctcc  tatgccccc  gcaggggag  660
gttctgatt  caaatttgt  gatggagaa  ggtaccgtg  ccgagtaga  aaag  714



<210> 9005
<211> 914
<212> PRT
<213> Homo sapiens
<308> XP_011618
<400> 9005

Met Ala Ser Ser Ala Gln Ser Gly Gly Ser Ser Gly Gly Pro Ala Val 
  1               5                  10                  15
Pro Thr Val Gln Arg Gly Ile Ile Lys Met Val Leu Ser Gly Cys Ala 
             20                  25                  30
Ile Ile Val Arg Gly Gln Pro Arg Gly Gly Pro Pro Pro Glu Arg Gln 
         35                  40                  45
Ile Asn Leu Ser Asn Ile Arg Ala Gly Asn Leu Ala Arg Arg Ala Ala 
     50                  55                  60
Ala Thr Gln Pro Asp Ala Lys Asp Thr Pro Asp Glu Pro Trp Ala Phe 
 65                  70                  75                  80
Pro Ala Arg Glu Phe Leu Arg Lys Lys Leu Ile Gly Lys Glu Val Cys 
                 85                  90                  95
Phe Thr Ile Glu Asn Lys Thr Pro Gln Gly Arg Glu Tyr Gly Met Ile 
             100                105                110
Tyr Leu Gly Lys Asp Thr Asn Gly Glu Asn Ile Ala Glu Ser Leu Val 
         115                120                125
Ala Glu Gly Leu Ala Thr Arg Arg Glu Gly Met Arg Ala Asn Asn Pro 
     130                135                140
Glu Gln Asn Arg Leu Ser Glu Cys Glu Glu Gln Ala Lys Ala Ala Lys 
 145                150                155                160
Lys Gly Met Trp Ser Glu Gly Asn Gly Ser His Thr Ile Arg Asp Leu 
                 165                170                175
Lys Tyr Thr Ile Glu Asn Pro Arg His Phe Val Asp Ser His His Gln 
             180                185                190
Lys Pro Val Asn Ala Ile Ile Glu His Val Arg Asp Gly Ser Val Val 
         195                200                205
Arg Ala Leu Leu Leu Pro Asp Tyr Tyr Leu Val Thr Val Met Leu Ser 
     210                215                220
Gly Ile Lys Cys Pro Thr Phe Arg Arg Glu Ala Asp Gly Ser Glu Thr 
 225                230                235                240
Pro Glu Pro Phe Ala Ala Glu Ala Lys Phe Phe Thr Glu Ser Arg Leu 
                 245                250                255
Leu Gln Arg Asp Val Gln Ile Ile Leu Glu Ser Cys His Asn Gln Asn 
             260                265                270
Ile Leu Gly Thr Ile Leu His Pro Asn Gly Asn Ile Thr Glu Leu Leu 
         275                280                285
Leu Lys Glu Gly Phe Ala Arg Cys Val Asp Trp Ser Ile Ala Val Tyr 
     290                295                300
Thr Arg Gly Ala Glu Lys Leu Arg Ala Ala Glu Arg Phe Ala Lys Glu 
 305                310                315                320
Arg Arg Leu Arg Ile Trp Arg Asp Tyr Val Ala Pro Thr Ala Asn Leu 
                 325                330                335
Asp Gln Lys Asp Lys Gln Phe Val Ala Lys Val Met Gln Val Leu Asn 
             340                345                350
Ala Asp Ala Ile Val Val Lys Leu Asn Ser Gly Asp Tyr Lys Thr Ile 
         355                360                365
His Leu Ser Ser Ile Arg Pro Pro Arg Leu Glu Gly Glu Asn Thr Gln 
     370                375                380
Asp Lys Asn Lys Lys Leu Arg Pro Leu Tyr Asp Ile Pro Tyr Met Phe 
 385                390                395                400
Glu Ala Arg Glu Phe Leu Arg Lys Lys Leu Ile Gly Lys Lys Val Asn 
                 405                410                415
Val Thr Val Asp Tyr Ile Arg Pro Ala Ser Pro Ala Thr Glu Thr Val 
             420                425                430
Pro Ala Phe Ser Glu Arg Thr Cys Ala Thr Val Thr Ile Gly Gly Ile 
         435                440                445
Asn Ile Ala Glu Ala Leu Val Ser Lys Gly Leu Ala Thr Val Ile Arg 
     450                455                460
Tyr Arg Gln Asp Asp Asp Gln Arg Ser Ser His Tyr Asp Glu Leu Leu 
 465                470                475                480
Ala Ala Glu Ala Arg Ala Ile Lys Asn Gly Lys Gly Leu His Ser Lys 
                 485                490                495
Lys Glu Val Pro Ile His Arg Val Ala Asp Ile Ser Gly Asp Thr Gln 
             500                505                510
Lys Ala Lys Gln Phe Leu Pro Phe Leu Gln Arg Ala Gly Arg Ser Glu 
         515                520                525
Ala Val Val Glu Tyr Val Phe Ser Gly Ser Arg Leu Lys Leu Tyr Leu 
     530                535                540
Pro Lys Glu Thr Cys Leu Ile Thr Phe Leu Leu Ala Gly Ile Glu Cys 
 545                550                555                560
Pro Arg Gly Ala Arg Asn Leu Pro Gly Leu Val Gln Glu Gly Glu Pro 
                 565                570                575
Phe Ser Glu Glu Ala Thr Leu Phe Thr Lys Glu Leu Val Leu Gln Arg 
             580                585                590
Glu Val Glu Val Glu Val Glu Ser Met Asp Lys Ala Gly Asn Phe Ile 
         595                600                605
Gly Trp Leu His Ile Asp Gly Ala Asn Leu Ser Val Leu Leu Val Glu 
     610                615                620
His Ala Leu Ser Lys Val His Phe Thr Ala Glu Arg Ser Ser Tyr Tyr 
 625                630                635                640
Lys Ser Leu Leu Ser Ala Glu Glu Ala Ala Lys Gln Lys Lys Glu Lys 
                 645                650                655
Val Trp Ala His Tyr Glu Glu Gln Pro Val Glu Glu Val Met Pro Val 
             660                665                670
Leu Glu Glu Lys Glu Arg Ser Ala Ser Tyr Lys Pro Val Phe Val Thr 
         675                680                685
Glu Ile Thr Asp Asp Leu His Phe Tyr Val Gln Asp Val Glu Thr Gly 
     690                695                700
Thr Gln Leu Glu Lys Leu Met Glu Asn Met Arg Asn Asp Ile Ala Ser 
 705                710                715                720
His Pro Pro Val Glu Gly Ser Tyr Ala Pro Arg Arg Gly Glu Phe Cys 
                 725                730                735
Ile Ala Lys Phe Val Asp Gly Glu Trp Tyr Arg Ala Arg Val Glu Lys 
             740                745                750
Val Glu Ser Pro Ala Lys Ile His Val Phe Tyr Ile Asp Tyr Gly Asn 
         755                760                765
Arg Glu Val Leu Pro Ser Thr Arg Leu Gly Thr Leu Ser Pro Ala Phe 
     770                775                780
Ser Thr Arg Val Leu Pro Ala Gln Ala Thr Glu Tyr Ala Phe Ala Phe 
 785                790                795                800
Ile Gln Val Pro Gln Asp Asp Asp Ala Arg Thr Asp Ala Val Asp Ser 
                 805                810                815
Val Val Arg Asp Ile Gln Asn Thr Gln Cys Leu Leu Asn Val Glu His 
             820                825                830
Leu Ser Ala Gly Cys Pro His Val Thr Leu Gln Phe Ala Asp Ser Lys 
         835                840                845
Gly Asp Val Gly Leu Gly Leu Val Lys Glu Gly Leu Val Met Val Glu 
     850                855                860
Val Arg Lys Glu Lys Gln Phe Gln Lys Val Ile Thr Glu Tyr Leu Asn 
 865                870                875                880
Ala Gln Glu Ser Ala Lys Ser Ala Arg Leu Asn Leu Trp Arg Tyr Gly 
                 885                890                895
Asp Phe Arg Ala Asp Asp Ala Asp Cys Pro Arg Pro Ser Ser Leu Ser 
             900                905                910
Asn Cys 
         915



<210> 9006
<211> 1399
<212> DNA
<213> Rattus norvegicus
<308> U83895
<400> 9006

gcgagctgg  gtctggcag  acgcgggct  cgggaggtc  gtggcggtc  gtggccgga  60
tcggtcgcc  gcaccatgg  ggacgatga  agctatgtc  ccagtgacc  gactgcaga  120
gagcgtcaa  aactggaga  catccggcg  aggaagcag  agctgctgg  tgacatcca  180
aggctgaag  aagagatag  agaggttgc  aatgaaatt  aaagcctgg  atccacaga  240
gaacggaaa  acatgcaga  gaacaaaca  gtagccatg  gcagaaaga  attcaacat  300
gatcctaag  aggggatcc  gttcttaat  gagaatggc  tgctgaaaa  cacttgtga  360
gacattgcc  agttcctgt  taaagggga  gggctcaac  aaacagcca  cggtgacta  420
cttggggag  gagatgagt  cagcatcca  gtcttgcat  catttgtgg  gctgcacga  480
ttcaccgac  tgaacctcg  ccaggcctt  cggcagttc  tgtggagct  ccggctccc  540
ggagaggcc  agaagattg  ccggatgat  gaggccttt  cgcagcggt  ctgtcagtg  600
aatactggg  tgttccagt  tacagacac  tgctatgtc  tgtcctttg  aatcatcat  660
ctgaacacc  gcctacaca  ccccaacgt  aaagacaag  ctacggtgg  gaggttcat  720
gccatgaac  gaggcatca  tgacggagg  gacctgccc  aggagctgc  gcggaatct  780
tatgagagc  tcaaaaacg  accctttaa  atcccagaa  atgacggca  tgatctcac  840
cacactttc  tcaatccag  ccgagaggg  tggctacta  agctcggag  tggcagggt  900
aagacttgg  agaggcgct  gttcattct  actgacaac  gcctttact  ctttgaata  960
accacggac  aagagcccc  cgggatcat  cccctggag  acctgagta  ccgagaggt  1020
gaagactcc  agaagccga  ctgctttga  ctttatatc  ctgacaata  agaccaggt  1080
attaaggcc  gcaagacag  ggctgacgg  cgagtggtg  aagggaacc  cactgtgta  1140
cgcatctcg  cccccactc  tgaggagaa  gaagactgg  tcaagtgca  caaagccgc  1200
atcagcaga  acccgttct  cgagatgct  gcagcacgg  aaaagaagg  ctcctccac  1260
aagaggcac  gagggtgca  cagggcacg  ccagcccgt  aagctgtgg  cccttctcc  1320
gcctcccct  agggcgctg  ggagcccag  agaggagag  agagggctt  tctgccagt  1380
cctgcccac  ccgctccta  1399



<210> 9007
<211> 398
<212> PRT
<213> Rattus norvegicus
<308> P97694
<400> 9007

Met Glu Asp Asp Asp Ser Tyr Val Pro Ser Asp Leu Thr Ala Glu Glu 
  1               5                  10                  15
Arg Gln Glu Leu Glu Asn Ile Arg Arg Arg Lys Gln Glu Leu Leu Ala 
             20                  25                  30
Asp Ile Gln Arg Leu Lys Glu Glu Ile Ala Glu Val Ala Asn Glu Ile 
         35                  40                  45
Glu Ser Leu Gly Ser Thr Glu Glu Arg Lys Asn Met Gln Arg Asn Lys 
     50                  55                  60
Gln Val Ala Met Gly Arg Lys Lys Phe Asn Met Asp Pro Lys Lys Gly 
 65                  70                  75                  80
Ile Gln Phe Leu Ile Glu Asn Gly Leu Leu Lys Asn Thr Cys Glu Asp 
                 85                  90                  95
Ile Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Thr Ala Ile 
             100                105                110
Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Ser Ile Gln Val Leu His 
         115                120                125
Ala Phe Val Glu Leu His Glu Phe Thr Asp Leu Asn Leu Val Gln Ala 
     130                135                140
Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu Ala Gln Lys 
 145                150                155                160
Ile Asp Arg Met Met Glu Ala Phe Ala Gln Arg Tyr Cys Gln Cys Asn 
                 165                170                175
Thr Gly Val Phe Gln Ser Thr Asp Thr Cys Tyr Val Leu Ser Phe Ala 
             180                185                190
Ile Ile Met Leu Asn Thr Ser Leu His Asn Pro Asn Val Lys Asp Lys 
         195                200                205
Pro Thr Val Glu Arg Phe Ile Ala Met Asn Arg Gly Ile Asn Asp Gly 
     210                215                220
Gly Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr Glu Ser Ile Lys 
 225                230                235                240
Asn Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn Asp Leu Thr His 
                 245                250                255
Thr Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Gly 
             260                265                270
Gly Arg Val Lys Thr Trp Lys Arg Arg Trp Phe Ile Leu Thr Asp Asn 
         275                280                285
Cys Leu Tyr Tyr Phe Glu Tyr Thr Thr Asp Lys Glu Pro Arg Gly Ile 
     290                295                300
Ile Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Glu Asp Ser Lys Lys 
 305                310                315                320
Pro Asn Cys Phe Glu Leu Tyr Ile Pro Asp Asn Lys Asp Gln Val Ile 
                 325                330                335
Lys Ala Cys Lys Thr Glu Ala Asp Gly Arg Val Val Glu Gly Asn His 
             340                345                350
Thr Val Tyr Arg Ile Ser Ala Pro Thr Pro Glu Glu Lys Glu Asp Trp 
         355                360                365
Ile Lys Cys Ile Lys Ala Ala Ile Ser Arg Asp Pro Phe Tyr Glu Met 
     370                375                380
Leu Ala Ala Arg Lys Lys Lys Val Ser Ser Thr Lys Arg His 
 385                390                395



<210> 9008
<211> 3311
<212> DNA
<213> Homo sapiens
<308> NM_004762
<400> 9008

gcgagcggg  gcgcgggtg  cgcggcggg  cgcgagcgg  gagccggag  gcgagcccg  60
tcccgcacc  tggaggagg  cgacagcta  gttcccagt  acctgacag  agaggagcg  120
caagaactg  agaacatcc  acggagaaa  caggagctg  tggctgaca  tcagaggct  180
aaggatgag  tagcagaag  agctaatga  attgaaaac  tgggatcca  agaggaaag  240
aaaaacatg  agaggaaca  acaggtagc  atgggcagg  aaaaattta  tatggaccc  300
aaaaagggg  tccagttct  aatagagaa  gacctcctg  agaacactt  tgaagacat  360
gcccagttc  tatataaag  cgaagggct  aacaagaca  ccatcggcg  ctacctagg  420
gagagagat  agtttaata  ccaggttct  catgcattt  tggagctgc  tgagttcac  480
gatcttaat  tcgtccagg  actacggca  ttcctgtgg  gcttccggc  acccggaga  540
gcccagaag  tcgaccgga  gatggaggc  tttgcccag  gatattgtc  gtgcaataa  600
ggcgtgttc  agtccacgg  tacttgtta  gtcctctcc  ttgccatca  catgttgaa  660
accagtctg  acaacccca  tgtcaaaga  aagcccact  tggagaggt  cattgccat  720
aaccgaggc  tcaatgatg  gggagacct  ccggaggag  tcctccgga  tctctatga  780
agcataaaa  atgaaccct  taaaatccc  gaagacgac  ggaatgacc  cactcacac  840
ttcttcaat  cagaccgag  aggctggct  ttgaaactc  gaggtggca  ggtaaagac  900
tggaagaga  gctggttca  tctgactga  aactgcctt  actactttg  gtataccac  960
gataaggag  cccgtggaa  catcccttt  gagaatctg  gtatccggg  agtggagga  1020
tccaaaaaa  caaactgct  tgagcttta  atccccgac  ataaagacc  agttatcaa  1080
gcctgcaag  ccgaggctg  cgggcgggt  gtggagggg  accacactg  ttaccggat  1140
tcagctccg  cgcccgagg  gaaggagga  tggattaag  gcattaaag  agccatcag  1200
agggaccct  tctacgaaa  gctcgcagc  cggaaaaag  aggtctcct  cacgaagcg  1260
cactgagcg  gcagccaag  gcgttggtc  gcgggggcc  tggagctcc  gctcttctc  1320
cgcacctcc  tggatgcac  gctgccgag  agagcgtcc  ctgccaggc  ccgccctgg  1380
ttcctagag  ctagcttca  cttttgcta  tttttttaa  tgggagaag  gtgggcagt  1440
atcactggg  aagagagga  cggccacct  tccagcatg  gctccagag  cttcctctc  1500
cacagggca  agctcttgt  ggcagggca  cctcctggc  agtttctct  ctcagtgtt  1560
tggtagcag  gctcagagc  aactgttta  ctcttggtt  tccccgtga  gaagccttc  1620
aaccctgca  cataaatac  tgtgtccat  tattattat  tgttaagag  aaaaggtgg  1680
aaggaagag  agccacata  tataaagat  tattttttt  ttttaagag  gaacgtagg  1740
ctgttcagg  gcattctgc  ctggctgcg  tggggagct  ctccctgga  aagagcacc  1800
ggggctgcg  ccaaggggc  tcagcctgg  cccgcggca  ggcctggcc  gcctctcct  1860
tgctgtggg  gctcgctgc  tggtgcttg  cttggcgag  tggacaggt  aggtcgagg  1920
cgcagaggg  agaggccca  tggagcctc  gacggcaca  tcagagtcg  gggcctgcc  1980
ggccggggt  gcagtcggc  gcagcgtgc  gtccggcat  tcccgcgga  gcttttcca  2040
cccaagtgc  tgcggagcc  gaggagagg  gagagctga  tggacgctt  cgttatttt  2100
ctccttcag  atccaagtt  ttgttgggc  ttaaagtag  aagtcagca  tttccttga  2160
ctaaatacc  aataaccaa  actgtgagg  aggttatcg  gacagaggt  ccggataac  2220
tgtttcatt  tgggttttc  tcctcttcc  cagactcca  tcctcgttc  agaggaagg  2280
gtaggactt  cccgatccc  gtagcttca  ctttttctg  ctcaaaacc  gccctaact  2340
gactactct  gatgcattt  gtggtgggc  ccctagagg  aagatgggc  tttatctgc  2400
ccgtggggt  cactggagt  aggggggtg  ccgggctgc  tctcgcatc  ctgtcttcc  2460
ctgcaggcg  tgtgtgagc  ggccctgcc  ctcctcatt  cagtatgaa  ggagccgtg  2520
cacgcagca  tttcctgcc  ttctctcag  gactctcag  gcagctcct  ccactccgc  2580
agggccagc  tgccagtcc  ggcagagca  gtggctggc  gtctggccg  ctcgccccg  2640
ccctccaca  gaccctgga  cagggcggt  cagggcgca  ccccgagga  gcaggtgga  2700
gagctgcgg  ttttcacag  gccgcgtcg  cacggctcc  ctgatcctt  agggttggc  2760
agcatctct  gaaatagct  ttgcagagg  gtggtggga  gaatagagg  ggacagtct  2820
tcacctccc  ccccgccac  ttgtgtaga  cctacctgg  gggaatggc  ttaggcact  2880
ttgtgccag  gcttgtgag  gtgacagaa  agggtccag  ctggaaacc  gaactttct  2940
ggtgggaga  ccaggtggt  cctgccgag  tctgggcgt  tttgggccg  tgctggagc  3000
tgtccagct  gcccgggcc  tggcctggt  ctcaagtgt  tcctagaca  agaggcacc  3060
gggtcagta  tagtctatt  atcagaggt  taaataatc  atgtatagt  tttctcctt  3120
tagattatt  tgtatttgt  taaaagaag  tttgtcaaa  tacaaaaat  taaagaaat  3180
actgaaagt  gttgacagg  tttttaaga  ataattatt  taattgttt  tgtttgttt  3240
tttttgcct  gtaaactag  gccaaggaa  tgcagcaaa  aaactccaa  tctgcccaa  3300
caaaaaaaa  a  3311



<210> 9009
<211> 398
<212> PRT
<213> Homo sapiens
<308> Q15438
<400> 9009

Met Glu Glu Asp Asp Ser Tyr Val Pro Ser Asp Leu Thr Ala Glu Glu 
  1               5                  10                  15
Arg Gln Glu Leu Glu Asn Ile Arg Arg Arg Lys Gln Glu Leu Leu Ala 
             20                  25                  30
Asp Ile Gln Arg Leu Lys Asp Glu Ile Ala Glu Val Ala Asn Glu Ile 
         35                  40                  45
Glu Asn Leu Gly Ser Thr Glu Glu Arg Lys Asn Met Gln Arg Asn Lys 
     50                  55                  60
Gln Val Ala Met Gly Arg Lys Lys Phe Asn Met Asp Pro Lys Lys Gly 
 65                  70                  75                  80
Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Lys Asn Thr Cys Glu Asp 
                 85                  90                  95
Ile Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Thr Ala Ile 
             100                105                110
Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn Ile Gln Val Leu His 
         115                120                125
Ala Phe Val Glu Leu His Glu Phe Thr Asp Leu Asn Leu Val Gln Ala 
     130                135                140
Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu Ala Gln Lys 
 145                150                155                160
Ile Asp Arg Met Met Glu Ala Phe Ala Gln Arg Tyr Cys Gln Cys Asn 
                 165                170                175
Asn Gly Val Phe Gln Ser Thr Asp Thr Cys Tyr Val Leu Ser Phe Ala 
             180                185                190
Ile Ile Met Leu Asn Thr Ser Leu His Asn Pro Asn Val Lys Asp Lys 
         195                200                205
Pro Thr Val Glu Arg Phe Ile Ala Met Asn Arg Gly Ile Asn Asp Gly 
     210                215                220
Gly Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr Glu Ser Ile Lys 
 225                230                235                240
Asn Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn Asp Leu Thr His 
                 245                250                255
Thr Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Gly 
             260                265                270
Gly Arg Val Lys Thr Trp Lys Arg Arg Trp Phe Ile Leu Thr Asp Asn 
         275                280                285
Cys Leu Tyr Tyr Phe Glu Tyr Thr Thr Asp Lys Glu Pro Arg Gly Ile 
     290                295                300
Ile Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Glu Asp Ser Lys Lys 
 305                310                315                320
Pro Asn Cys Phe Glu Leu Tyr Ile Pro Asp Asn Lys Asp Gln Val Ile 
                 325                330                335
Lys Ala Cys Lys Thr Glu Ala Asp Gly Arg Val Val Glu Gly Asn His 
             340                345                350
Thr Val Tyr Arg Ile Ser Ala Pro Thr Pro Glu Glu Lys Glu Glu Trp 
         355                360                365
Ile Lys Cys Ile Lys Ala Ala Ile Ser Arg Asp Pro Phe Tyr Glu Met 
     370                375                380
Leu Ala Ala Arg Lys Lys Lys Val Ser Ser Thr Lys Arg His 
 385                390                395



<210> 9010
<211> 1561
<212> DNA
<213> Rattus norvegicus
<308> U83896
<400> 9010

gcgggcccc  ccggccggg  ggttgggcc  tgaagggag  gtcttttcg  cgctgagga  60
gggcgctga  gaggcggcg  tggctcctg  ggcgtttga  cgggctcac  cgagcccgc  120
ggccgacgc  gacgcaggc  cagccggcg  aaacgcccc  gactccccg  gggccttcc  180
agccgccat  gaggacggt  tctacgagc  cccagactt  actccagag  agcgcatgg  240
gctggagaa  atccgtcgg  gaaagcagg  gctgctggt  gagatccag  gcctccggg  300
agagctaag  gaagctatg  gcgaagtgg  gggtctgga  gccaatgag  gcagtaaga  360
cttgcagcg  aaccggaag  tggcaatgg  ccggaagaa  ttcaacatg  accccaaaa  420
ggggatcca  ttcttggtg  agcatgaac  tctacagaa  acacctgag  aaattgccc  480
cttcctgta  aagggcgag  ggctgaaca  gacagccat  ggggactac  taggggaaa  540
ggaagagct  aacctgtct  tgctccatg  ttttgtgga  ctacatgag  tcaccgacc  600
caatctggt  caggccctc  ggcaattcc  gtggagctt  cgcctccct  gagaggctc  660
gaaaattga  cgaatgatg  aggcctttg  ccagagata  tgcttatgt  atcccgggg  720
cttccagtc  acagacacc  gctacgtgt  gtccttcgc  gtgatcatg  tgaacacca  780
ccttcacaa  cccaatgtc  gggacaagc  gggcctgga  cgctttgtg  ccatgaacc  840
aggcatcaa  gagggtggg  acctgcctg  ggaccttct  aggaacctc  atgacagca  900
ccgaaacga  cccttcaaa  tccctgagg  tgatgggaa  gatctcacc  acaccttct  960
caacccaga  cgagagggc  ggctcctaa  gctgggagg  ggccgggtg  agacttgga  1020
gcgtcgctg  ttcatcctc  cagacaact  cctctacta  tttgagtac  ctacggaca  1080
ggagcccag  gggatcatc  ccctagaga  cctgagcat  cgtgaggtg  atgatcctc  1140
gaagccgaa  tgctttgag  tttacattc  caacaataa  ggacagctc  tcaaagcct  1200
caaaacgga  gctgatggt  gggtagtag  ggggaacca  atggtgtac  gaatctcag  1260
acccacaca  gaggagaaa  acgagtgga  caagtccat  caggctgct  taagcgtgg  1320
ccccttcta  gagatgttg  cagcaagaa  gaagcggat  tctgtgaag  agaagcaag  1380
acaaccctg  ccctgtccc  aactccatt  tttattttg  agctgcccc  cctgggtgg  1440
aggacccct  ggccctggg  ctgtggatc  tggttccct  tttggaaaa  caccacctc  1500
agctcctga  tccttattt  taattaaca  gttggtaat  ttattaatt  tttaacccc  1560
c  1561



<210> 9011
<211> 400
<212> PRT
<213> Rattus norvegicus
<308> P97695
<400> 9011

Met Glu Asp Gly Val Tyr Glu Pro Pro Asp Leu Thr Pro Glu Glu Arg 
  1               5                  10                  15
Met Glu Leu Glu Asn Ile Arg Arg Arg Lys Gln Glu Leu Leu Val Glu 
             20                  25                  30
Ile Gln Arg Leu Arg Glu Glu Leu Ser Glu Ala Met Ser Glu Val Glu 
         35                  40                  45
Gly Leu Glu Ala Asn Glu Gly Ser Lys Thr Leu Gln Arg Asn Arg Lys 
     50                  55                  60
Met Ala Met Gly Arg Lys Lys Phe Asn Met Asp Pro Lys Lys Gly Ile 
 65                  70                  75                  80
Gln Phe Leu Val Glu His Glu Leu Leu Gln Asn Thr Pro Glu Glu Ile 
                 85                  90                  95
Ala Arg Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Thr Ala Ile Gly 
             100                105                110
Asp Tyr Leu Gly Glu Arg Glu Glu Leu Asn Leu Ser Val Leu His Ala 
         115                120                125
Phe Val Asp Leu His Glu Phe Thr Asp Leu Asn Leu Val Gln Ala Leu 
     130                135                140
Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu Ala Gln Lys Ile 
 145                150                155                160
Asp Arg Met Met Glu Ala Phe Ala Gln Arg Tyr Cys Leu Cys Asn Pro 
                 165                170                175
Gly Val Phe Gln Ser Thr Asp Thr Cys Tyr Val Leu Ser Phe Ala Val 
             180                185                190
Ile Met Leu Asn Thr Ser Leu His Asn Pro Asn Val Arg Asp Lys Pro 
         195                200                205
Gly Leu Glu Arg Phe Val Ala Met Asn Arg Gly Ile Asn Glu Gly Gly 
     210                215                220
Asp Leu Pro Glu Asp Leu Leu Arg Asn Leu Tyr Asp Ser Ile Arg Asn 
 225                230                235                240
Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn Asp Leu Thr His Thr 
                 245                250                255
Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Gly Gly 
             260                265                270
Arg Val Lys Thr Trp Lys Arg Arg Trp Phe Ile Leu Thr Asp Asn Cys 
         275                280                285
Leu Tyr Tyr Phe Glu Tyr Thr Thr Asp Lys Glu Pro Arg Gly Ile Ile 
     290                295                300
Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Asp Asp Pro Arg Lys Pro 
 305                310                315                320
Asn Cys Phe Glu Leu Tyr Ile Pro Asn Asn Lys Gly Gln Leu Ile Lys 
                 325                330                335
Ala Cys Lys Thr Glu Ala Asp Gly Arg Val Val Glu Gly Asn His Met 
             340                345                350
Val Tyr Arg Ile Ser Ala Pro Thr Gln Glu Glu Lys Asp Glu Trp Ile 
         355                360                365
Lys Ser Ile Gln Ala Ala Val Ser Val Asp Pro Phe Tyr Glu Met Leu 
     370                375                380
Ala Ala Arg Lys Lys Arg Ile Ser Val Lys Lys Lys Gln Glu Gln Pro 
 385                390                395                400



<210> 9012
<211> 311
<212> DNA
<213> Homo sapiens
<308> AA371941
<400> 9012

ctgcccctg  gcacccctc  ctgtgccca  cctgtttct  tngcctgcg  ctcttgggg  60
tgctccatt  tcccgcctt  ccttctcct  cacctggtc  tgcctgctt  ctcgctgtc  120
gccccagga  gtaggtaca  gacctgtct  tgtctccca  cccttccct  tcagggggc  180
gggtgaaga  gtggaagcg  cgctggttt  tcctcacag  caactgcct  tactacttt  240
agtacacca  ggacaagga  ccccgagga  tcatccccc  gggagaaat  tgaggcatt  300
cgagaaggt  g  311



<210> 9013
<211> 400
<212> PRT
<213> Homo sapiens
<308> Q99418
<400> 9013

Met Glu Asp Gly Val Tyr Glu Pro Pro Asp Leu Thr Pro Glu Glu Arg 
  1               5                  10                  15
Met Glu Leu Glu Asn Ile Arg Arg Arg Lys Gln Glu Leu Leu Val Glu 
             20                  25                  30
Ile Gln Arg Leu Arg Glu Glu Leu Ser Glu Ala Met Ser Glu Val Glu 
         35                  40                  45
Gly Leu Glu Ala Asn Glu Gly Ser Lys Thr Leu Gln Arg Asn Arg Lys 
     50                  55                  60
Met Ala Met Gly Arg Lys Lys Phe Asn Met Asp Pro Lys Lys Gly Ile 
 65                  70                  75                  80
Gln Phe Leu Val Glu Asn Glu Leu Leu Gln Asn Thr Pro Glu Glu Ile 
                 85                  90                  95
Ala Arg Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Thr Ala Ile Gly 
             100                105                110
Asp Tyr Leu Gly Glu Arg Glu Glu Leu Asn Leu Ala Val Leu His Ala 
         115                120                125
Phe Val Asp Leu His Glu Phe Thr Asp Leu Asn Leu Val Gln Ala Leu 
     130                135                140
Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu Ala Gln Lys Ile 
 145                150                155                160
Asp Arg Met Met Glu Ala Phe Ala Gln Arg Tyr Cys Leu Cys Asn Pro 
                 165                170                175
Gly Val Phe Gln Ser Thr Asp Thr Cys Tyr Val Leu Ser Phe Ala Val 
             180                185                190
Ile Met Leu Asn Thr Ser Leu His Asn Pro Asn Val Arg Asp Lys Pro 
         195                200                205
Gly Leu Glu Arg Phe Val Ala Met Asn Arg Gly Ile Asn Glu Gly Gly 
     210                215                220
Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr Asp Ser Ile Arg Asn 
 225                230                235                240
Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn Asp Leu Thr His Thr 
                 245                250                255
Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Gly Gly 
             260                265                270
Arg Val Lys Thr Trp Lys Arg Arg Trp Phe Ile Leu Thr Asp Asn Cys 
         275                280                285
Leu Tyr Tyr Phe Glu Tyr Thr Thr Asp Lys Glu Pro Arg Gly Ile Ile 
     290                295                300
Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Asp Asp Pro Arg Lys Pro 
 305                310                315                320
Asn Cys Phe Glu Leu Tyr Ile Pro Asn Asn Lys Gly Gln Leu Ile Lys 
                 325                330                335
Ala Cys Lys Thr Glu Ala Asp Gly Arg Val Val Glu Gly Asn His Met 
             340                345                350
Val Tyr Arg Ile Ser Ala Pro Thr Gln Glu Glu Lys Asp Glu Trp Ile 
         355                360                365
Lys Ser Ile Gln Ala Ala Val Ser Val Asp Pro Phe Tyr Glu Met Leu 
     370                375                380
Ala Ala Arg Lys Lys Arg Ile Ser Val Lys Lys Lys Gln Glu Gln Pro 
 385                390                395                400



<210> 9014
<211> 1081
<212> DNA
<213> Rattus norvegicus
<308> U84410
<400> 9014

gcttggaac  gtacgcgaa  aaaagtgac  atggacaac  acgaaacct  cgtggattc  60
aaatccatt  ataattttg  aacaaagac  atccatgga  gcaagtcga  ggactctgg  120
atatatctg  acagcagtt  caaaatgga  taccctgaa  tgggcttgt  tataataat  180
aataataag  acttccata  aagcactgg  atgtcagct  gcaatggta  cgatgtcga  240
gcagctaac  tcagagaga  attcatggc  ctgaaatac  aagtcagga  taaaaatga  300
cttactcgt  aagaaatta  ggaattgat  gatagtgtt  ctaaggaag  tcacagcaa  360
aggagcagt  ttgtgtgtg  gattctaag  catggagat  aaggagtaa  ttttggaac  420
aacggacct  tggacctga  aaaactaac  agtttcttc  gaggcgact  ctgccggag  480
ctgactgga  agccgaaac  cttcatcat  caggcctgc  gaggtacag  gctggactg  540
ggtattgag  cagacagtg  aactgacga  gatatggca  gccagaaga  accagtggg  600
gccgacttc  tgtatgctt  ctctaccgc  cccggttac  attcctgga  aaattcaag  660
gacgggtca  ggttcatcc  gtcactttg  gccatgctg  aactgtacg  gcacaagct  720
gaattcatg  acatcctca  tcgtgttaa  cggaaggtg  ccatggaat  tgagtcctt  780
tccctggac  ccactttcc  cgcaaagaa  cagatcccg  gtattgtgt  aatgctcac  840
aaagaactg  acttttatc  ctaaaggaa  gactgggag  ggggtaggg  catgtttct  900
ttttggttt  tttttggtt  ttggtttgt  ttttttttt  ttatttgaa  gccaaatga  960
aaaactgtc  gggagactt  ttttttccc  tctcattta  atcaaatcc  atgttccag  1020
tcgtcattg  acaatacca  tgcctgcaa  gcagccaca  tacaatacc  cagctttga  1080
a  1081



<210> 9015
<211> 277
<212> PRT
<213> Rattus norvegicus
<308> P55213
<400> 9015

Met Asp Asn Asn Glu Thr Ser Val Asp Ser Lys Ser Ile Asn Asn Phe 
  1               5                  10                  15
Glu Thr Lys Thr Ile His Gly Ser Lys Ser Met Asp Ser Gly Ile Tyr 
             20                  25                  30
Leu Asp Ser Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
         35                  40                  45
Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Ser Ala Arg 
     50                  55                  60
Asn Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Met Ala 
 65                  70                  75                  80
Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                 85                  90                  95
Met Glu Leu Met Asp Ser Val Ser Lys Glu Asp His Ser Lys Arg Ser 
             100                105                110
Ser Phe Val Cys Val Ile Leu Ser His Gly Asp Glu Gly Val Ile Phe 
         115                120                125
Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Leu Thr Ser Phe Phe Arg 
     130                135                140
Gly Asp Tyr Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
 145                150                155                160
Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                 165                170                175
Gly Thr Asp Asp Asp Met Ala Cys Gln Lys Ile Pro Val Glu Ala Asp 
             180                185                190
Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
         195                200                205
Ser Arg Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
     210                215                220
Leu Tyr Ala His Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
 225                230                235                240
Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Leu Asp Ala Thr Phe 
                 245                250                255
His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
             260                265                270
Leu Tyr Phe Tyr His 
         275



<210> 9016
<211> 834
<212> DNA
<213> Homo sapiens
<308> U26943
<400> 9016

atggagaac  ctgaaaact  agtggattc  aaatccatt  aaaatttgg  accaaagat  60
atacatgga  gcgaatcaa  ggactctgg  atatccctg  acaacagtt  taaaatgga  120
tatcctgag  tgggtttat  tataataat  aataataag  attttcata  aagcactgg  180
atgacatct  ggtctggta  agatgtcga  gcagcaaac  tcagggaaa  attcagaaa  240
ttgaaatat  aagtcagga  taaaaatga  cttacacgt  aagaaattg  ggaattgat  300
cgtgatgtt  ctaaagaag  tcacagcaa  aggagcagt  ttgtttgtg  gcttctgag  360
catggtgaa  aaggaataa  ttttggaac  aatggacct  ttgacctga  aaaaataac  420
aactttttc  gaggggatc  ttgtagaag  ctaactgga  aacccaaac  tttcattat  480
caggcctgc  gtggtacag  actggactg  ggcattgag  cagacagtg  tgttgatga  540
gacatggcg  gtcataaaa  accagtgga  gccgacttc  tgtatgcat  ctccacagc  600
cctggttat  attcttggc  aaattcaaa  gatggctcc  ggttcatcc  gtcgctttg  660
gccatgctg  aacagtatg  cgacaagct  gaatttatg  acattctta  ccgggttaa  720
cgaaaggtg  caacagaat  tgagtcctt  tcctttgac  ctacttttc  tgcaaagaa  780
cagattcca  gtattgttt  catgctcac  aaagaactc  atttttatc  ctaa  834



<210> 9017
<211> 277
<212> PRT
<213> Homo sapiens
<308> P42574
<400> 9017

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
  1               5                  10                  15
Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
             20                  25                  30
Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
         35                  40                  45
Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
     50                  55                  60
Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
 65                  70                  75                  80
Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                 85                  90                  95
Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
             100                105                110
Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
         115                120                125
Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
     130                135                140
Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
 145                150                155                160
Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                 165                170                175
Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Asp Ala Asp 
             180                185                190
Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
         195                200                205
Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
     210                215                220
Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
 225                230                235                240
Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                 245                250                255
His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
             260                265                270
Leu Tyr Phe Tyr His 
         275



<210> 9018
<211> 678
<212> DNA
<213> Rattus norvegicus
<308> U86635
<400> 9018

atgtcgtgc  ccaagtcta  ggttctggg  tactgggat  tccgcgggc  ggctcatgc  60
atccgtatg  tcctggagt  tactgatac  agctatgaa  agaaacagt  cacgtgtgg  120
gaagctcct  actatgata  aagccaatg  ctggacgtg  aattcaagc  agatctgga  180
tttcctaac  tgccctacc  tatggacgg  aagaacaag  tcacccaga  taacgccat  240
ttgcggtac  tcgcacgca  gcacaacat  tgtggtgac  ccgaagaag  aaagattcg  300
gtggacatc  tggagaacc  gataatgga  ttccgcatg  agctggttc  gctctgcta  360
aattctaac  acgaaagcc  gaagcctca  tatttggaa  aactgcctg  acagctgaa  420
cagttctcg  tgttcctgg  gaaattcac  tggtttgca  gagaaaagc  gaccttcgt  480
gattttctc  cttatgacg  cttggacca  aatcgtatg  ttgagccca  gtgcctgga  540
gagttccca  atctgaagg  tttcatgtg  cgttttgag  ctttggaga  gattgctgc  600
ttcctgcag  ctgaccgct  cttcaagat  ccaatcaac  acaagatgg  caagtgggg  660
aacaagagc  tatgctga  678



<210> 9019
<211> 217
<212> PRT
<213> Rattus norvegicus
<308> A29036
<400> 9019

Pro Met Thr Leu Gly Tyr Trp Asp Ile Arg Gly Leu Ala His Ala Ile 
  1               5                  10                  15
Arg Leu Leu Leu Glu Tyr Thr Asp Ser Ser Tyr Glu Glu Lys Arg Tyr 
             20                  25                  30
Thr Met Gly Asp Ala Pro Asp Phe Asp Arg Ser Gln Trp Leu Asn Glu 
         35                  40                  45
Lys Phe Lys Leu Gly Leu Asp Phe Pro Asn Leu Pro Tyr Leu Ile Asp 
     50                  55                  60
Gly Ser His Lys Ile Thr Gln Ser Asn Ala Ile Leu Arg Tyr Leu Gly 
 65                  70                  75                  80
Arg Lys His Asn Leu Cys Gly Glu Thr Glu Glu Glu Arg Ile Arg Val 
                 85                  90                  95
Asp Ile Leu Glu Asn Gln Leu Met Asp Asn Arg Met Val Leu Ala Arg 
             100                105                110
Leu Cys Tyr Asn Pro Asp Phe Glu Lys Leu Lys Pro Gly Tyr Leu Glu 
         115                120                125
Gln Leu Pro Gly Met Met Arg Leu Tyr Ser Glu Phe Leu Gly Lys Arg 
     130                135                140
Pro Trp Phe Ala Gly Asp Lys Ile Thr Phe Val Asp Phe Ile Ala Tyr 
 145                150                155                160
Asp Val Leu Glu Arg Asn Gln Val Phe Glu Ala Thr Cys Leu Asp Ala 
                 165                170                175
Phe Pro Asn Leu Lys Asp Phe Ile Ala Arg Phe Glu Gly Leu Lys Lys 
             180                185                190
Ile Ser Asp Tyr Met Lys Ser Ser Arg Phe Leu Pro Arg Pro Leu Phe 
         195                200                205
Thr Lys Met Ala Ile Trp Gly Ser Lys 
     210                215



<210> 9020
<211> 1286
<212> DNA
<213> Homo sapiens
<308> BC000088
<400> 9020

ggcacgagg  ggaagcccg  caccatgtc  tgcgagtcg  ctatggttc  cgggtactg  60
gatattcgt  ggctggcgc  cgccatccg  ctgctcctg  agttcacgg  tacctctta  120
gaggagaaa  ggtacacgt  cggggaagc  cctgactat  atcgaagcc  atggctgga  180
gtgaaattc  agctagacc  ggactttcc  aatctgccc  acctcctgg  tgggaagaa  240
aagatcacc  agagcaatg  catcttgcg  tacatcgct  gcaagcaca  catgtgtgg  300
gagactgaa  aagaaaaga  tcgagtgga  atcatagag  accaagtaa  ggatttccg  360
acacaactg  taaggctct  ttacagctc  gaccacgaa  aactgaagc  tcagtactt  420
gaagagcta  ctggacaac  gaaacaatt  tccatgttt  tggggaaat  ctcatggtt  480
gccggggaa  agctcacct  tgtggattt  ctcacctat  atatcttgg  tcagaaccg  540
atatttgac  ccaagtgcc  ggatgagtt  ccaaacctg  aggctttca  gtgccgttt  600
gaggctttg  agaaaatcg  tgcctactt  cagtctgat  agttctgca  gatgcccat  660
aacaacaag  tggcccagt  gggcaacaa  cctgtatgc  gagcaggag  cagacttgc  720
gagcttgtt  tgtttcatc  tgtccgtaa  gggtcagcg  tcttgcttt  ctcttttca  780
tgaatagca  ttatgttac  ggtgtccag  tgagtttct  ttgggtata  aggctaaaa  840
ggaaaaagg  tatgtggag  atcatcaag  tatgaattg  atcgctgcg  tactggcat  900
tccctactc  ccaactgag  tcaagggct  taggttcat  cccaagccc  gagagtggg  960
actagaaaa  acgagattg  acagttgga  agagcaggt  tgttaaatg  gactggagt  1020
cctgtgaag  ctgggtgag  ataacacaa  taaaactgt  gtactgatg  acttaaccg  1080
agttcggaa  ccgtcctgt  tacacatgg  agtttagtg  gataaaggc  gtatttcag  1140
ctggtgggc  agccaatag  gttgggaca  ttgcttact  attaaaaat  atagagccc  1200
acttgacac  attcactaa  attaatctg  aatttaagg  ccaacatta  acacaaagc  1260
gttgaaata  aaaaaaaaa  aaaaaa  1286



<210> 9021
<211> 224
<212> PRT
<213> Homo sapiens
<308> P21266
<400> 9021

Ser Cys Glu Ser Ser Met Val Leu Gly Tyr Trp Asp Ile Arg Gly Leu 
  1               5                  10                  15
Ala His Ala Ile Arg Leu Leu Leu Glu Phe Thr Asp Thr Ser Tyr Glu 
             20                  25                  30
Glu Lys Arg Tyr Thr Cys Gly Glu Ala Pro Asp Tyr Asp Arg Ser Gln 
         35                  40                  45
Trp Leu Asp Val Lys Phe Lys Leu Asp Leu Asp Phe Pro Asn Leu Pro 
     50                  55                  60
Tyr Leu Leu Asp Gly Lys Asn Lys Ile Thr Gln Ser Asn Ala Ile Leu 
 65                  70                  75                  80
Arg Tyr Ile Ala Arg Lys His Asn Met Cys Gly Glu Thr Glu Glu Glu 
                 85                  90                  95
Lys Ile Arg Val Asp Ile Ile Glu Asn Gln Val Met Asp Phe Arg Thr 
             100                105                110
Gln Leu Ile Arg Leu Cys Tyr Ser Ser Asp His Glu Lys Leu Lys Pro 
         115                120                125
Gln Tyr Leu Glu Glu Leu Pro Gly Gln Leu Lys Gln Phe Ser Met Phe 
     130                135                140
Leu Gly Lys Phe Ser Trp Phe Ala Gly Glu Lys Leu Thr Phe Val Asp 
 145                150                155                160
Phe Leu Thr Tyr Asp Ile Leu Asp Gln Asn Arg Ile Phe Asp Pro Lys 
                 165                170                175
Cys Leu Asp Glu Phe Pro Asn Leu Lys Ala Phe Met Cys Arg Phe Glu 
             180                185                190
Ala Leu Glu Lys Ile Ala Ala Tyr Leu Gln Ser Asp Gln Phe Cys Lys 
         195                200                205
Met Pro Ile Asn Asn Lys Met Ala Gln Trp Gly Asn Lys Pro Val Cys 
     210                215                220



<210> 9022
<211> 678
<212> DNA
<213> Rattus norvegicus
<308> U86635
<400> 9022

atgtcgtgc  ccaagtcta  ggttctggg  tactgggat  tccgcgggc  ggctcatgc  60
atccgtatg  tcctggagt  tactgatac  agctatgaa  agaaacagt  cacgtgtgg  120
gaagctcct  actatgata  aagccaatg  ctggacgtg  aattcaagc  agatctgga  180
tttcctaac  tgccctacc  tatggacgg  aagaacaag  tcacccaga  taacgccat  240
ttgcggtac  tcgcacgca  gcacaacat  tgtggtgac  ccgaagaag  aaagattcg  300
gtggacatc  tggagaacc  gataatgga  ttccgcatg  agctggttc  gctctgcta  360
aattctaac  acgaaagcc  gaagcctca  tatttggaa  aactgcctg  acagctgaa  420
cagttctcg  tgttcctgg  gaaattcac  tggtttgca  gagaaaagc  gaccttcgt  480
gattttctc  cttatgacg  cttggacca  aatcgtatg  ttgagccca  gtgcctgga  540
gagttccca  atctgaagg  tttcatgtg  cgttttgag  ctttggaga  gattgctgc  600
ttcctgcag  ctgaccgct  cttcaagat  ccaatcaac  acaagatgg  caagtgggg  660
aacaagagc  tatgctga  678



<210> 9023
<211> 217
<212> PRT
<213> Rattus norvegicus
<308> A29036
<400> 9023

Pro Met Thr Leu Gly Tyr Trp Asp Ile Arg Gly Leu Ala His Ala Ile 
  1               5                  10                  15
Arg Leu Leu Leu Glu Tyr Thr Asp Ser Ser Tyr Glu Glu Lys Arg Tyr 
             20                  25                  30
Thr Met Gly Asp Ala Pro Asp Phe Asp Arg Ser Gln Trp Leu Asn Glu 
         35                  40                  45
Lys Phe Lys Leu Gly Leu Asp Phe Pro Asn Leu Pro Tyr Leu Ile Asp 
     50                  55                  60
Gly Ser His Lys Ile Thr Gln Ser Asn Ala Ile Leu Arg Tyr Leu Gly 
 65                  70                  75                  80
Arg Lys His Asn Leu Cys Gly Glu Thr Glu Glu Glu Arg Ile Arg Val 
                 85                  90                  95
Asp Ile Leu Glu Asn Gln Leu Met Asp Asn Arg Met Val Leu Ala Arg 
             100                105                110
Leu Cys Tyr Asn Pro Asp Phe Glu Lys Leu Lys Pro Gly Tyr Leu Glu 
         115                120                125
Gln Leu Pro Gly Met Met Arg Leu Tyr Ser Glu Phe Leu Gly Lys Arg 
     130                135                140
Pro Trp Phe Ala Gly Asp Lys Ile Thr Phe Val Asp Phe Ile Ala Tyr 
 145                150                155                160
Asp Val Leu Glu Arg Asn Gln Val Phe Glu Ala Thr Cys Leu Asp Ala 
                 165                170                175
Phe Pro Asn Leu Lys Asp Phe Ile Ala Arg Phe Glu Gly Leu Lys Lys 
             180                185                190
Ile Ser Asp Tyr Met Lys Ser Ser Arg Phe Leu Pro Arg Pro Leu Phe 
         195                200                205
Thr Lys Met Ala Ile Trp Gly Ser Lys 
     210                215



<210> 9024
<211> 1286
<212> DNA
<213> Homo sapiens
<308> BC000088
<400> 9024

ggcacgagg  ggaagcccg  caccatgtc  tgcgagtcg  ctatggttc  cgggtactg  60
gatattcgt  ggctggcgc  cgccatccg  ctgctcctg  agttcacgg  tacctctta  120
gaggagaaa  ggtacacgt  cggggaagc  cctgactat  atcgaagcc  atggctgga  180
gtgaaattc  agctagacc  ggactttcc  aatctgccc  acctcctgg  tgggaagaa  240
aagatcacc  agagcaatg  catcttgcg  tacatcgct  gcaagcaca  catgtgtgg  300
gagactgaa  aagaaaaga  tcgagtgga  atcatagag  accaagtaa  ggatttccg  360
acacaactg  taaggctct  ttacagctc  gaccacgaa  aactgaagc  tcagtactt  420
gaagagcta  ctggacaac  gaaacaatt  tccatgttt  tggggaaat  ctcatggtt  480
gccggggaa  agctcacct  tgtggattt  ctcacctat  atatcttgg  tcagaaccg  540
atatttgac  ccaagtgcc  ggatgagtt  ccaaacctg  aggctttca  gtgccgttt  600
gaggctttg  agaaaatcg  tgcctactt  cagtctgat  agttctgca  gatgcccat  660
aacaacaag  tggcccagt  gggcaacaa  cctgtatgc  gagcaggag  cagacttgc  720
gagcttgtt  tgtttcatc  tgtccgtaa  gggtcagcg  tcttgcttt  ctcttttca  780
tgaatagca  ttatgttac  ggtgtccag  tgagtttct  ttgggtata  aggctaaaa  840
ggaaaaagg  tatgtggag  atcatcaag  tatgaattg  atcgctgcg  tactggcat  900
tccctactc  ccaactgag  tcaagggct  taggttcat  cccaagccc  gagagtggg  960
actagaaaa  acgagattg  acagttgga  agagcaggt  tgttaaatg  gactggagt  1020
cctgtgaag  ctgggtgag  ataacacaa  taaaactgt  gtactgatg  acttaaccg  1080
agttcggaa  ccgtcctgt  tacacatgg  agtttagtg  gataaaggc  gtatttcag  1140
ctggtgggc  agccaatag  gttgggaca  ttgcttact  attaaaaat  atagagccc  1200
acttgacac  attcactaa  attaatctg  aatttaagg  ccaacatta  acacaaagc  1260
gttgaaata  aaaaaaaaa  aaaaaa  1286



<210> 9025
<211> 224
<212> PRT
<213> Homo sapiens
<308> P21266
<400> 9025

Ser Cys Glu Ser Ser Met Val Leu Gly Tyr Trp Asp Ile Arg Gly Leu 
  1               5                  10                  15
Ala His Ala Ile Arg Leu Leu Leu Glu Phe Thr Asp Thr Ser Tyr Glu 
             20                  25                  30
Glu Lys Arg Tyr Thr Cys Gly Glu Ala Pro Asp Tyr Asp Arg Ser Gln 
         35                  40                  45
Trp Leu Asp Val Lys Phe Lys Leu Asp Leu Asp Phe Pro Asn Leu Pro 
     50                  55                  60
Tyr Leu Leu Asp Gly Lys Asn Lys Ile Thr Gln Ser Asn Ala Ile Leu 
 65                  70                  75                  80
Arg Tyr Ile Ala Arg Lys His Asn Met Cys Gly Glu Thr Glu Glu Glu 
                 85                  90                  95
Lys Ile Arg Val Asp Ile Ile Glu Asn Gln Val Met Asp Phe Arg Thr 
             100                105                110
Gln Leu Ile Arg Leu Cys Tyr Ser Ser Asp His Glu Lys Leu Lys Pro 
         115                120                125
Gln Tyr Leu Glu Glu Leu Pro Gly Gln Leu Lys Gln Phe Ser Met Phe 
     130                135                140
Leu Gly Lys Phe Ser Trp Phe Ala Gly Glu Lys Leu Thr Phe Val Asp 
 145                150                155                160
Phe Leu Thr Tyr Asp Ile Leu Asp Gln Asn Arg Ile Phe Asp Pro Lys 
                 165                170                175
Cys Leu Asp Glu Phe Pro Asn Leu Lys Ala Phe Met Cys Arg Phe Glu 
             180                185                190
Ala Leu Glu Lys Ile Ala Ala Tyr Leu Gln Ser Asp Gln Phe Cys Lys 
         195                200                205
Met Pro Ile Asn Asn Lys Met Ala Gln Trp Gly Asn Lys Pro Val Cys 
     210                215                220



<210> 9026
<211> 678
<212> DNA
<213> Rattus norvegicus
<308> U86635
<400> 9026

atgtcgtgc  ccaagtcta  ggttctggg  tactgggat  tccgcgggc  ggctcatgc  60
atccgtatg  tcctggagt  tactgatac  agctatgaa  agaaacagt  cacgtgtgg  120
gaagctcct  actatgata  aagccaatg  ctggacgtg  aattcaagc  agatctgga  180
tttcctaac  tgccctacc  tatggacgg  aagaacaag  tcacccaga  taacgccat  240
ttgcggtac  tcgcacgca  gcacaacat  tgtggtgac  ccgaagaag  aaagattcg  300
gtggacatc  tggagaacc  gataatgga  ttccgcatg  agctggttc  gctctgcta  360
aattctaac  acgaaagcc  gaagcctca  tatttggaa  aactgcctg  acagctgaa  420
cagttctcg  tgttcctgg  gaaattcac  tggtttgca  gagaaaagc  gaccttcgt  480
gattttctc  cttatgacg  cttggacca  aatcgtatg  ttgagccca  gtgcctgga  540
gagttccca  atctgaagg  tttcatgtg  cgttttgag  ctttggaga  gattgctgc  600
ttcctgcag  ctgaccgct  cttcaagat  ccaatcaac  acaagatgg  caagtgggg  660
aacaagagc  tatgctga  678



<210> 9027
<211> 217
<212> PRT
<213> Rattus norvegicus
<308> A29036
<400> 9027

Pro Met Thr Leu Gly Tyr Trp Asp Ile Arg Gly Leu Ala His Ala Ile 
  1               5                  10                  15
Arg Leu Leu Leu Glu Tyr Thr Asp Ser Ser Tyr Glu Glu Lys Arg Tyr 
             20                  25                  30
Thr Met Gly Asp Ala Pro Asp Phe Asp Arg Ser Gln Trp Leu Asn Glu 
         35                  40                  45
Lys Phe Lys Leu Gly Leu Asp Phe Pro Asn Leu Pro Tyr Leu Ile Asp 
     50                  55                  60
Gly Ser His Lys Ile Thr Gln Ser Asn Ala Ile Leu Arg Tyr Leu Gly 
 65                  70                  75                  80
Arg Lys His Asn Leu Cys Gly Glu Thr Glu Glu Glu Arg Ile Arg Val 
                 85                  90                  95
Asp Ile Leu Glu Asn Gln Leu Met Asp Asn Arg Met Val Leu Ala Arg 
             100                105                110
Leu Cys Tyr Asn Pro Asp Phe Glu Lys Leu Lys Pro Gly Tyr Leu Glu 
         115                120                125
Gln Leu Pro Gly Met Met Arg Leu Tyr Ser Glu Phe Leu Gly Lys Arg 
     130                135                140
Pro Trp Phe Ala Gly Asp Lys Ile Thr Phe Val Asp Phe Ile Ala Tyr 
 145                150                155                160
Asp Val Leu Glu Arg Asn Gln Val Phe Glu Ala Thr Cys Leu Asp Ala 
                 165                170                175
Phe Pro Asn Leu Lys Asp Phe Ile Ala Arg Phe Glu Gly Leu Lys Lys 
             180                185                190
Ile Ser Asp Tyr Met Lys Ser Ser Arg Phe Leu Pro Arg Pro Leu Phe 
         195                200                205
Thr Lys Met Ala Ile Trp Gly Ser Lys 
     210                215



<210> 9028
<211> 1286
<212> DNA
<213> Homo sapiens
<308> BC000088
<400> 9028

ggcacgagg  ggaagcccg  caccatgtc  tgcgagtcg  ctatggttc  cgggtactg  60
gatattcgt  ggctggcgc  cgccatccg  ctgctcctg  agttcacgg  tacctctta  120
gaggagaaa  ggtacacgt  cggggaagc  cctgactat  atcgaagcc  atggctgga  180
gtgaaattc  agctagacc  ggactttcc  aatctgccc  acctcctgg  tgggaagaa  240
aagatcacc  agagcaatg  catcttgcg  tacatcgct  gcaagcaca  catgtgtgg  300
gagactgaa  aagaaaaga  tcgagtgga  atcatagag  accaagtaa  ggatttccg  360
acacaactg  taaggctct  ttacagctc  gaccacgaa  aactgaagc  tcagtactt  420
gaagagcta  ctggacaac  gaaacaatt  tccatgttt  tggggaaat  ctcatggtt  480
gccggggaa  agctcacct  tgtggattt  ctcacctat  atatcttgg  tcagaaccg  540
atatttgac  ccaagtgcc  ggatgagtt  ccaaacctg  aggctttca  gtgccgttt  600
gaggctttg  agaaaatcg  tgcctactt  cagtctgat  agttctgca  gatgcccat  660
aacaacaag  tggcccagt  gggcaacaa  cctgtatgc  gagcaggag  cagacttgc  720
gagcttgtt  tgtttcatc  tgtccgtaa  gggtcagcg  tcttgcttt  ctcttttca  780
tgaatagca  ttatgttac  ggtgtccag  tgagtttct  ttgggtata  aggctaaaa  840
ggaaaaagg  tatgtggag  atcatcaag  tatgaattg  atcgctgcg  tactggcat  900
tccctactc  ccaactgag  tcaagggct  taggttcat  cccaagccc  gagagtggg  960
actagaaaa  acgagattg  acagttgga  agagcaggt  tgttaaatg  gactggagt  1020
cctgtgaag  ctgggtgag  ataacacaa  taaaactgt  gtactgatg  acttaaccg  1080
agttcggaa  ccgtcctgt  tacacatgg  agtttagtg  gataaaggc  gtatttcag  1140
ctggtgggc  agccaatag  gttgggaca  ttgcttact  attaaaaat  atagagccc  1200
acttgacac  attcactaa  attaatctg  aatttaagg  ccaacatta  acacaaagc  1260
gttgaaata  aaaaaaaaa  aaaaaa  1286



<210> 9029
<211> 224
<212> PRT
<213> Homo sapiens
<308> P21266
<400> 9029

Ser Cys Glu Ser Ser Met Val Leu Gly Tyr Trp Asp Ile Arg Gly Leu 
  1               5                  10                  15
Ala His Ala Ile Arg Leu Leu Leu Glu Phe Thr Asp Thr Ser Tyr Glu 
             20                  25                  30
Glu Lys Arg Tyr Thr Cys Gly Glu Ala Pro Asp Tyr Asp Arg Ser Gln 
         35                  40                  45
Trp Leu Asp Val Lys Phe Lys Leu Asp Leu Asp Phe Pro Asn Leu Pro 
     50                  55                  60
Tyr Leu Leu Asp Gly Lys Asn Lys Ile Thr Gln Ser Asn Ala Ile Leu 
 65                  70                  75                  80
Arg Tyr Ile Ala Arg Lys His Asn Met Cys Gly Glu Thr Glu Glu Glu 
                 85                  90                  95
Lys Ile Arg Val Asp Ile Ile Glu Asn Gln Val Met Asp Phe Arg Thr 
             100                105                110
Gln Leu Ile Arg Leu Cys Tyr Ser Ser Asp His Glu Lys Leu Lys Pro 
         115                120                125
Gln Tyr Leu Glu Glu Leu Pro Gly Gln Leu Lys Gln Phe Ser Met Phe 
     130                135                140
Leu Gly Lys Phe Ser Trp Phe Ala Gly Glu Lys Leu Thr Phe Val Asp 
 145                150                155                160
Phe Leu Thr Tyr Asp Ile Leu Asp Gln Asn Arg Ile Phe Asp Pro Lys 
                 165                170                175
Cys Leu Asp Glu Phe Pro Asn Leu Lys Ala Phe Met Cys Arg Phe Glu 
             180                185                190
Ala Leu Glu Lys Ile Ala Ala Tyr Leu Gln Ser Asp Gln Phe Cys Lys 
         195                200                205
Met Pro Ile Asn Asn Lys Met Ala Gln Trp Gly Asn Lys Pro Val Cys 
     210                215                220



<210> 9030
<211> 2838
<212> DNA
<213> Rattus norvegicus
<308> U87306
<400> 9030

atgagggcc  ggagcgggg  gcggggcgc  ctgctgctg  cgctgctgc  ctgctggga  60
ccgacaccg  gcttagcag  cattgactc  ggtggccag  cactcccag  ctccttccc  120
tcagcaccc  cggagcagc  gcctcactt  ctgctggaa  cagaggatg  ctacatcgt  180
aagaacaag  cagtggaat  gcactgccg  gccttccct  ccacacaga  ctacttcaa  240
tgtaatggc  agtgggtta  ccagaaagg  cacgtcacg  aggagagcc  ggatgaggc  300
acaggcttg  gaatacgag  ggtgcagat  gaggtgtcg  ggcagcagg  ggaggaact  360
tttgggctc  aggactact  gtgtcagtg  gtggcctgg  gctcttcgg  aaccaccaa  420
agtcgccga  cctacatcc  cattgccta  ttgcgcaag  actttgacc  ggagcctct  480
gcgaaggag  tacccttgg  tcatgaggt  cttctgcag  gccgcccac  agagggagt  540
cctgtggct  aggtggaat  gctcaagaa  gaagatgtc  tcgatcccg  tcaggacac  600
aacttcctg  tcaccattg  ccacaacct  atcatccgc  aggcgcgcc  ctcagacac  660
gccaactac  cctgtgtgg  aaagaatat  gtggccaag  gccggagca  gacggccac  720
gtcatcgtc  atgtgaacg  aggttggtc  agctgggca  aatggtcac  ctgctctaa  780
cgctgcggc  gaggttggc  gaaacgtac  aggacctgc  ccaacccag  cccactcaa  840
ggaggtgcc  tctgcgagg  acaggcttg  cagaagacg  cttgcacca  cgtgtgccc  900
gtggatgga  cgtggactg  gtggagcaa  tggtccgcc  gcagcacag  gtgtgcgca  960
tggcgcagc  gcgagtgca  ggcaccgcc  ccccagaac  gaggccgtg  ctgcagcgg  1020
acgctactt  actccaaga  ctgcaccga  gggctgtgc  tgctgaatc  gagaactct  1080
aacgaccct  aaagccgcc  cctggagcc  tcgggagac  tggcgctgt  tgcgggcct  1140
gtggtggcc  tctttgtgg  tctggcagt  ctcatggct  taggagtga  cgtgtaccg  1200
agaaactgc  gggacttcg  cacggacat  actgactcc  ctgctgccc  cactggtgg  1260
ttccacccc  tcaacttca  gactgcaag  cccagcaac  cacagctcc  gcacccatc  1320
gcccctccg  acctaacgg  cagtgctgg  atctaccgc  gacctgtgt  tgccctgca  1380
gactctgcc  acaagatcc  tatgactaa  tcacccctt  tggatccct  gcccagcct  1440
aagatcaag  tctatgact  cagcaccat  ggctctggg  ctggcctgg  tgatggagc  1500
gacctgctg  gtgtcttac  acccggtac  tacccaggc  atttctccc  ggacaccca  1560
ttcctgcac  tgcgcagcg  cagccttgg  tcccagcac  tcctgggcc  ccctcgaga  1620
cccagcagc  gtgtcagtg  cacctttgg  tgcctgggt  ggaggctga  cattcccgg  1680
acaggggtc  gcctgttgg  accaaatgg  gccattccc  agggcaagt  ctatgactt  1740
tatctacgt  tcaacaaga  tgaaagcac  ctcccactt  cggaaggtt  ccagacagt  1800
ttgagcccc  cggtgacct  cgggcccac  ggcctcctc  tgtgccgcc  tgttgtcct  1860
actgtgccc  actgtgctg  agtcattgc  ggagactgg  tcttccagc  caagaccca  1920
gcccatcag  gccactggg  ggaggtggt  actttggat  aggagactc  gaacacccc  1980
tgctactgc  agctagagg  taaatcctg  cacatcctg  tggaccagc  gggtaccta  2040
gtgttcacg  gcgagtcct  ctcccgctc  gcagtcaag  ggctccagc  agccatctt  2100
gccccagcc  tctgcacct  cctggagta  agtctcagg  tctactgtc  ggaggacac  2160
cctgcagca  tgaaggagg  cctagagct  gagaggact  tgggtggct  cttggtgga  2220
gagcccaag  ctttgctct  taaggacag  taccacaac  tacgnctct  cctccatga  2280
atcccccat  cccactgga  gagcaaact  ctggccaag  accaggaga  tcccttcta  2340
catgtgtgg  acggcagcc  gaaagccct  cactgcact  tcaccctgg  gagacatag  2400
ctagcctcc  ctgagttca  ctgtaaggt  tgcgtgcgg  aggtagaag  ggaaggcca  2460
attttccag  tgcacacca  gctggctga  acgcctgct  gctccctgg  tgcactctg  2520
tctgcccct  gcaatgctg  caccacaca  ctgggaccc  atgccttca  gataccact  2580
tccatccgc  agaagatct  caacagcct  gacgccccc  actcacggg  caatgactg  2640
cggctgttg  cacagaagc  ctccatgga  cggtacctg  actacttcg  caccaaagc  2700
agtcccaca  gcgtgatct  agacctctg  gaagctcgg  agcaggatg  tggggacct  2760
aacagcctg  ccagtgcct  ggaggagat  ggcaagagt  agatgctgg  agccatgac  2820
actgatggc  attgctga  2838



<210> 9031
<211> 945
<212> PRT
<213> Rattus norvegicus
<308> AAB57679
<400> 9031

Met Arg Ala Arg Ser Gly Ala Arg Gly Ala Leu Leu Leu Ala Leu Leu 
  1               5                  10                  15
Leu Cys Trp Asp Pro Thr Pro Ser Leu Ala Gly Ile Asp Ser Gly Gly 
             20                  25                  30
Gln Ala Leu Pro Asp Ser Phe Pro Ser Ala Pro Ala Glu Gln Leu Pro 
         35                  40                  45
His Phe Leu Leu Glu Pro Glu Asp Ala Tyr Ile Val Lys Asn Lys Pro 
     50                  55                  60
Val Glu Leu His Cys Arg Ala Phe Pro Ala Thr Gln Ile Tyr Phe Lys 
 65                  70                  75                  80
Cys Asn Gly Glu Trp Val Ser Gln Lys Gly His Val Thr Gln Glu Ser 
                 85                  90                  95
Leu Asp Glu Ala Thr Gly Leu Arg Ile Arg Glu Val Gln Ile Glu Val 
             100                105                110
Ser Arg Gln Gln Val Glu Glu Leu Phe Gly Leu Glu Asp Tyr Trp Cys 
         115                120                125
Gln Cys Val Ala Trp Ser Ser Ser Gly Thr Thr Lys Ser Arg Arg Ala 
     130                135                140
Tyr Ile Arg Ile Ala Tyr Leu Arg Lys Asn Phe Asp Gln Glu Pro Leu 
 145                150                155                160
Ala Lys Glu Val Pro Leu Asp His Glu Val Leu Leu Gln Cys Arg Pro 
                 165                170                175
Pro Glu Gly Val Pro Val Ala Glu Val Glu Trp Leu Lys Asn Glu Asp 
             180                185                190
Val Ile Asp Pro Ala Gln Asp Thr Asn Phe Leu Leu Thr Ile Asp His 
         195                200                205
Asn Leu Ile Ile Arg Gln Ala Arg Leu Ser Asp Thr Ala Asn Tyr Thr 
     210                215                220
Cys Val Ala Lys Asn Ile Val Ala Lys Arg Arg Ser Thr Thr Ala Thr 
 225                230                235                240
Val Ile Val Tyr Val Asn Gly Gly Trp Ser Ser Trp Ala Glu Trp Ser 
                 245                250                255
Pro Cys Ser Asn Arg Cys Gly Arg Gly Trp Gln Lys Arg Thr Arg Thr 
             260                265                270
Cys Thr Asn Pro Ala Pro Leu Asn Gly Gly Ala Phe Cys Glu Gly Gln 
         275                280                285
Ala Cys Gln Lys Thr Ala Cys Thr Thr Val Cys Pro Val Asp Gly Ala 
     290                295                300
Trp Thr Glu Trp Ser Lys Trp Ser Ala Cys Ser Thr Glu Cys Ala His 
 305                310                315                320
Trp Arg Ser Arg Glu Cys Met Ala Pro Pro Pro Gln Asn Gly Gly Arg 
                 325                330                335
Asp Cys Ser Gly Thr Leu Leu Asp Ser Lys Asn Cys Thr Asp Gly Leu 
             340                345                350
Cys Val Leu Asn Gln Arg Thr Leu Asn Asp Pro Lys Ser Arg Pro Leu 
         355                360                365
Glu Pro Ser Gly Asp Val Ala Leu Tyr Ala Gly Leu Val Val Ala Val 
     370                375                380
Phe Val Val Leu Ala Val Leu Met Ala Val Gly Val Ile Val Tyr Arg 
 385                390                395                400
Arg Asn Cys Arg Asp Phe Asp Thr Asp Ile Thr Asp Ser Ser Ala Ala 
                 405                410                415
Leu Thr Gly Gly Phe His Pro Val Asn Phe Lys Thr Ala Arg Pro Ser 
             420                425                430
Asn Pro Gln Leu Leu His Pro Ser Ala Pro Pro Asp Leu Thr Ala Ser 
         435                440                445
Ala Gly Ile Tyr Arg Gly Pro Val Tyr Ala Leu Gln Asp Ser Ala Asp 
     450                455                460
Lys Ile Pro Met Thr Asn Ser Pro Leu Leu Asp Pro Leu Pro Ser Leu 
 465                470                475                480
Lys Ile Lys Val Tyr Asp Ser Ser Thr Ile Gly Ser Gly Ala Gly Leu 
                 485                490                495
Ala Asp Gly Ala Asp Leu Leu Gly Val Leu Pro Pro Gly Thr Tyr Pro 
             500                505                510
Gly Asp Phe Ser Arg Asp Thr His Phe Leu His Leu Arg Ser Ala Ser 
         515                520                525
Leu Gly Ser Gln His Leu Leu Gly Leu Pro Arg Asp Pro Ser Ser Ser 
     530                535                540
Val Ser Gly Thr Phe Gly Cys Leu Gly Gly Arg Leu Thr Ile Pro Gly 
 545                550                555                560
Thr Gly Val Ser Leu Leu Val Pro Asn Gly Ala Ile Pro Gln Gly Lys 
                 565                570                575
Phe Tyr Asp Leu Tyr Leu Arg Ile Asn Lys Thr Glu Ser Thr Leu Pro 
             580                585                590
Leu Ser Glu Gly Ser Gln Thr Val Leu Ser Pro Ser Val Thr Cys Gly 
         595                600                605
Pro Thr Gly Leu Leu Leu Cys Arg Pro Val Val Leu Thr Val Pro His 
     610                615                620
Cys Ala Glu Val Ile Ala Gly Asp Trp Ile Phe Gln Leu Lys Thr Gln 
 625                630                635                640
Ala His Gln Gly His Trp Glu Glu Val Val Thr Leu Asp Glu Glu Thr 
                 645                650                655
Leu Asn Thr Pro Cys Tyr Cys Gln Leu Glu Ala Lys Ser Cys His Ile 
             660                665                670
Leu Leu Asp Gln Leu Gly Thr Tyr Val Phe Thr Gly Glu Ser Tyr Ser 
         675                680                685
Arg Ser Ala Val Lys Arg Leu Gln Leu Ala Ile Phe Ala Pro Ala Leu 
     690                695                700
Cys Thr Ser Leu Glu Tyr Ser Leu Arg Val Tyr Cys Leu Glu Asp Thr 
 705                710                715                720
Pro Ala Ala Leu Lys Glu Val Leu Glu Leu Glu Arg Thr Leu Gly Gly 
                 725                730                735
Tyr Leu Val Glu Glu Pro Lys Thr Leu Leu Phe Lys Asp Ser Tyr His 
             740                745                750
Asn Leu Arg Leu Ser Leu His Asp Ile Pro His Ala His Trp Arg Ser 
         755                760                765
Lys Leu Leu Ala Lys Tyr Gln Glu Ile Pro Phe Tyr His Val Trp Asn 
     770                775                780
Gly Ser Gln Lys Ala Leu His Cys Thr Phe Thr Leu Glu Arg His Ser 
 785                790                795                800
Leu Ala Ser Thr Glu Phe Thr Cys Lys Val Cys Val Arg Gln Val Glu 
                 805                810                815
Gly Glu Gly Gln Ile Phe Gln Leu His Thr Thr Leu Ala Glu Thr Pro 
             820                825                830
Ala Gly Ser Leu Asp Ala Leu Cys Ser Ala Pro Gly Asn Ala Ala Thr 
         835                840                845
Thr Gln Leu Gly Pro Tyr Ala Phe Lys Ile Pro Leu Ser Ile Arg Gln 
     850                855                860
Lys Ile Cys Asn Ser Leu Asp Ala Pro Asn Ser Arg Gly Asn Asp Trp 
 865                870                875                880
Arg Leu Leu Ala Gln Lys Leu Ser Met Asp Arg Tyr Leu Asn Tyr Phe 
                 885                890                895
Ala Thr Lys Ala Ser Pro Thr Gly Val Ile Leu Asp Leu Trp Glu Ala 
             900                905                910
Arg Gln Gln Asp Asp Gly Asp Leu Asn Ser Leu Ala Ser Ala Leu Glu 
         915                920                925
Glu Met Gly Lys Ser Glu Met Leu Val Ala Met Thr Thr Asp Gly Asp 
     930                935                940
Cys 
 945



<210> 9032
<211> 1948
<212> DNA
<213> Homo sapiens
<308> AK022859
<400> 9032

ctagcgatt  cgcccggga  acccacttc  tgcacctgc  cagcgccag  ctcggttcc  60
agcagctct  gggcctgcc  cgagaccca  ggagcagcg  cagcggcac  tttggctgc  120
tgggtggga  gctcagcat  cccggcaca  gggtcagct  gctggtgcc  aatggagcc  180
ttccccagg  caagttcta  gagatgtat  tactcatca  caaggcaga  agtaccctc  240
cgctttcag  agggaccca  acagtattg  gcccctcgg  gacctgtgg  cccacaggc  300
tcctgctgt  ccgccccgt  atcctcacc  tgccccact  tgccgaagt  agtgcccgt  360
actggatct  tcagctcaa  acccaggcc  accagggcc  ctgggagga  gtggtgacc  420
tggatgagg  gaccctgaa  acaccctgc  actgccagc  ggagcccag  gcctgtcac  480
tcctgctgg  ccagctggg  acctacgtg  tcacgggcg  gtcctattc  cgctcagca  540
tcaagcggc  ccagctggc  gtcttcgcc  ccgccctct  cacctccct  gagtacagc  600
tccgggtct  ctgcctgga  gacacgcct  tagcactga  ggaggtgct  gagctggag  660
ggactctgg  cggatactt  gtggaggag  cgaaaccgc  aatgttcaa  gacagttac  720
acaacctgc  cctctccct  catgacctc  cccatgccc  ttggaggag  aagctgctg  780
ccaaatacc  ggagatccc  ttctatcac  tttggagtg  cagccagaa  gccctccac  840
gcactttca  cctggagag  cacagcttg  cctccacag  gctcacctg  aagatctgc  900
tgcggcaag  ggaagggga  ggccagata  tccagctgc  taccactct  gcagagaca  960
ctgctggct  cctggacac  ctctgctct  cccctggca  cactgtcac  acccagccg  1020
gaccttatg  cttcaagat  ccactgtcc  tccgccaga  gatatgcaa  agcctagat  1080
cccccaact  acggggcaa  gactggcgg  tgttagcac  gaagctctc  atggaccgg  1140
acctgaatt  ctttgccac  aaagcgagc  ccacgggtg  gatcctgga  ctctgggaa  1200
ctctgcagc  ggacgatgg  gacctcaac  gcctggcga  tgccttgga  gagatgggc  1260
agagtgaga  gctggtggc  gtggccacc  acggggact  ctgagcctc  tgggacagc  1320
ggctggcag  gactggcag  aggcaggtg  agggaggcc  ggggcagcc  cctgatggg  1380
atgtttggc  tctgcttcc  cccagttca  agccagagt  gcctctcct  ctcctcttc  1440
ccaaccccc  gaccatgac  agccttaga  aatccatgt  ctctgttgt  agagggccc  1500
gagttcctt  tccaccccc  ctctctctc  cttggcctg  gatctctgt  caggaacca  1560
gatggggct  aagcctctg  aggcagttg  ttgggggcg  gcaggcagg  ggccctccc  1620
ccacccccc  accctcagc  cggcaactt  tgggttcca  gggttttag  tccgttctc  1680
ttttcttcc  ccgttattg  tttctcctt  ctccctaag  ccccttctg  ttccacgcc  1740
ttttcctct  tgaagagtc  agtacaatt  agacaaact  ctttctcct  tccaaaagc  1800
aaaaggcaa  ggaaagaaa  aaagcttca  accgctagt  aggctcaaa  aagaagaaa  1860
acaccaaaa  cacaaggga  aagaaaaac  cagtttctt  ggaaacgca  acgatttat  1920
atccagatt  tttggataa  tccttttt  1948



<210> 9033
<211> 931
<212> PRT
<213> Homo sapiens
<308> AAC67491
<400> 9033

Met Arg Lys Gly Leu Arg Ala Thr Ala Ala Arg Cys Gly Leu Gly Leu 
  1               5                  10                  15
Gly Tyr Leu Leu Gln Met Leu Val Leu Pro Ala Leu Ala Leu Leu Ser 
             20                  25                  30
Ala Ser Gly Thr Gly Ser Ala Ala Gln Asp Asp Asp Phe Phe His Glu 
         35                  40                  45
Leu Pro Glu Thr Phe Pro Ser Asp Pro Pro Glu Pro Leu Pro His Phe 
     50                  55                  60
Leu Ile Glu Pro Glu Glu Ala Tyr Ile Val Lys Asn Lys Pro Val Asn 
 65                  70                  75                  80
Leu Tyr Cys Lys Ala Ser Pro Ala Thr Gln Ile Tyr Phe Lys Cys Asn 
                 85                  90                  95
Ser Glu Trp Val His Gln Lys Asp His Ile Val Asp Glu Arg Val Asp 
             100                105                110
Glu Thr Ser Gly Leu Ile Val Arg Glu Val Ser Ile Glu Ile Ser Arg 
         115                120                125
Gln Gln Val Glu Glu Leu Phe Gly Pro Glu Asp Tyr Trp Cys Gln Cys 
     130                135                140
Val Ala Trp Ser Ser Ala Gly Thr Thr Lys Ser Arg Lys Ala Tyr Val 
 145                150                155                160
Arg Ile Ala Tyr Leu Arg Lys Thr Phe Glu Gln Glu Pro Leu Gly Lys 
                 165                170                175
Glu Val Ser Leu Glu Gln Glu Val Leu Leu Gln Cys Arg Pro Pro Glu 
             180                185                190
Gly Ile Pro Val Ala Glu Val Glu Trp Leu Lys Asn Glu Asp Ile Ile 
         195                200                205
Asp Pro Val Glu Asp Arg Asn Phe Tyr Ile Thr Ile Asp His Asn Leu 
     210                215                220
Ile Ile Lys Gln Ala Arg Leu Ser Asp Thr Ala Asn Tyr Thr Cys Val 
 225                230                235                240
Ala Lys Asn Ile Val Ala Lys Arg Lys Ser Thr Thr Ala Thr Val Ile 
                 245                250                255
Val Tyr Val Asn Gly Gly Trp Ser Thr Trp Thr Glu Trp Ser Val Cys 
             260                265                270
Asn Ser Arg Cys Gly Arg Gly Tyr Gln Lys Arg Thr Arg Thr Cys Thr 
         275                280                285
Asn Pro Ala Pro Leu Asn Gly Gly Ala Phe Cys Glu Gly Gln Ser Val 
     290                295                300
Gln Lys Ile Ala Cys Thr Thr Leu Cys Pro Val Asp Gly Arg Trp Thr 
 305                310                315                320
Pro Trp Ser Lys Trp Ser Thr Cys Gly Thr Glu Cys Thr His Trp Arg 
                 325                330                335
Arg Arg Glu Cys Thr Ala Pro Ala Pro Lys Asn Gly Gly Lys Asp Cys 
             340                345                350
Asp Gly Leu Val Leu Gln Ser Lys Asn Cys Thr Asp Gly Leu Cys Met 
         355                360                365
Gln Thr Ala Pro Asp Ser Asp Asp Val Ala Leu Tyr Val Gly Ile Val 
     370                375                380
Ile Ala Val Ile Val Cys Leu Ala Ile Ser Val Val Val Ala Leu Phe 
 385                390                395                400
Val Tyr Arg Lys Asn His Arg Asp Phe Glu Ser Asp Ile Ile Asp Ser 
                 405                410                415
Ser Ala Leu Asn Gly Gly Phe Gln Pro Val Asn Ile Lys Ala Ala Arg 
             420                425                430
Gln Asp Leu Leu Ala Val Pro Pro Asp Leu Thr Ser Ala Ala Ala Met 
         435                440                445
Tyr Arg Gly Pro Val Tyr Ala Leu His Asp Val Ser Asp Lys Ile Pro 
     450                455                460
Met Thr Asn Ser Pro Ile Leu Asp Pro Leu Pro Asn Leu Lys Ile Lys 
 465                470                475                480
Val Tyr Asn Thr Ser Gly Ala Val Ser Pro Gln Asp Asp Leu Ser Glu 
                 485                490                495
Phe Thr Ser Lys Leu Ser Pro Gln Met Thr Gln Ser Leu Leu Glu Asn 
             500                505                510
Glu Ala Leu Ser Leu Lys Asn Gln Ser Leu Ala Arg Gln Thr Asp Pro 
         515                520                525
Ser Cys Thr Ala Phe Gly Ser Phe Asn Ser Leu Gly Gly His Leu Ile 
     530                535                540
Val Pro Asn Ser Gly Val Ser Leu Leu Ile Pro Ala Gly Ala Ile Pro 
 545                550                555                560
Gln Gly Arg Val Tyr Glu Met Tyr Val Thr Val His Arg Lys Glu Thr 
                 565                570                575
Met Arg Pro Pro Met Asp Asp Ser Gln Thr Leu Leu Thr Pro Val Val 
             580                585                590
Ser Cys Gly Pro Pro Gly Ala Leu Leu Thr Arg Pro Val Val Leu Thr 
         595                600                605
Met His His Cys Ala Asp Pro Asn Thr Glu Asp Trp Lys Ile Leu Leu 
     610                615                620
Lys Asn Gln Ala Ala Gln Gly Gln Trp Glu Asp Val Val Val Val Gly 
 625                630                635                640
Glu Glu Asn Phe Thr Thr Pro Cys Tyr Ile Lys Leu Asp Ala Glu Ala 
                 645                650                655
Cys His Ile Leu Thr Glu Asn Leu Ser Thr Tyr Ala Leu Val Gly His 
             660                665                670
Ser Thr Thr Lys Ala Ala Ala Lys Arg Leu Lys Leu Ala Ile Phe Gly 
         675                680                685
Pro Leu Cys Cys Ser Ser Leu Glu Tyr Ser Ile Arg Val Tyr Cys Leu 
     690                695                700
Asp Asp Thr Gln Asp Ala Leu Lys Glu Ile Leu His Leu Glu Arg Gln 
 705                710                715                720
Thr Gly Gly Gln Leu Leu Glu Glu Pro Lys Ala Leu His Phe Lys Gly 
                 725                730                735
Ser Thr His Asn Leu Arg Leu Ser Ile His Asp Ile Ala His Ser Leu 
             740                745                750
Trp Lys Ser Lys Leu Leu Ala Lys Tyr Gln Glu Ile Pro Phe Tyr His 
         755                760                765
Val Trp Ser Gly Ser Gln Arg Asn Leu His Cys Thr Phe Thr Leu Glu 
     770                775                780
Arg Phe Ser Leu Asn Thr Val Glu Leu Val Cys Lys Leu Cys Val Arg 
 785                790                795                800
Gln Val Glu Gly Glu Gly Gln Ile Phe Gln Leu Asn Cys Thr Val Ser 
                 805                810                815
Glu Glu Pro Thr Gly Ile Asp Leu Pro Leu Leu Asp Pro Ala Asn Thr 
             820                825                830
Ile Thr Thr Val Thr Gly Pro Ser Ala Phe Ser Ile Pro Leu Pro Ile 
         835                840                845
Arg Gln Lys Leu Cys Ser Ser Leu Asp Ala Pro Gln Thr Arg Gly His 
     850                855                860
Asp Trp Arg Met Leu Ala His Lys Leu Asn Leu Asp Arg Tyr Leu Asn 
 865                870                875                880
Tyr Phe Ala Thr Lys Ser Ser Pro Thr Gly Val Ile Leu Asp Leu Trp 
                 885                890                895
Glu Ala Gln Asn Phe Pro Asp Gly Asn Leu Ser Met Leu Ala Ala Val 
             900                905                910
Leu Glu Glu Met Gly Arg His Glu Thr Val Val Ser Leu Ala Ala Glu 
         915                920                925
Gly Gln Tyr 
     930



<210> 9034
<211> 770
<212> DNA
<213> Rattus norvegicus
<308> U87971
<400> 9034

gtacgtgta  gtgacgtgg  ggctccagt  ctttggtcc  gcttccact  cttacaagt  60
cggcgagga  gcggcaacg  cctgaggag  gtagcggtg  cggtaggca  cagaagagt  120
cgaggttat  cgactcgat  atcccgcgg  aacgctacg  atctaagaa  acggatcag  180
gtgtctacc  gggtctctc  aagacacag  ttctgtccc  tgcaactgc  atcaatagc  240
gcagtgaca  cgctccttt  cccaccccg  tggccctgg  cccctcccc  cccgacact  300
tgtcctgcc  ggatcggac  caggagttc  tgtctgcct  caagtcgct  cagagccgt  360
agaatggaa  ccaaacaaa  aaaccagct  tgcacgcta  ccggcagtg  agcgagttt  420
ccctcatgg  caggcgcat  gggaaagat  tcagcaata  atttgccaa  ctggagaag  480
taacaatcc  ggcaaagcg  aagtccctc  ttgatgata  agcagtaga  attgaggaa  540
taacataca  catcaaaca  gacatcaat  gcctcaaca  acaaattgc  cagcttcaa  600
attttgtga  ggccaaggg  agccagagt  gccggcatc  gcagaccca  tccaacacc  660
ttgtagttt  attgcagtc  aaactggct  ccatgtcca  tgacttcaa  tctgttttg  720
aagtgagga  tgaaaatct  aaacagcag  ggaaccgtc  ggaacagttc  770



<210> 9035
<211> 211
<212> PRT
<213> Rattus norvegicus
<308> AAB93844
<400> 9035

Met Ile Pro Arg Lys Arg Tyr Gly Ser Lys Asn Thr Asp Gln Gly Val 
  1               5                  10                  15
Tyr Leu Gly Leu Ser Lys Thr Gln Val Leu Ser Pro Ala Thr Ala Ile 
             20                  25                  30
Asn Ser Ser Ser Asp Ile Ala Pro Leu Pro Thr Pro Val Ala Leu Val 
         35                  40                  45
Pro Ser Pro Pro Asp Thr Met Ser Cys Arg Asp Arg Thr Gln Glu Phe 
     50                  55                  60
Leu Ser Ala Cys Lys Ser Leu Gln Ser Arg Gln Asn Gly Ile Gln Thr 
 65                  70                  75                  80
Asn Lys Pro Ala Leu His Ala Thr Arg Gln Cys Ser Glu Phe Thr Leu 
                 85                  90                  95
Met Ala Arg Arg Ile Gly Lys Asp Leu Ser Asn Thr Phe Ala Lys Leu 
             100                105                110
Glu Lys Leu Thr Ile Leu Ala Lys Arg Lys Ser Leu Phe Asp Asp Lys 
         115                120                125
Ala Val Glu Ile Glu Glu Leu Thr Tyr Ile Ile Lys Gln Asp Ile Asn 
     130                135                140
Ser Leu Asn Lys Gln Ile Ala Gln Leu Gln Asp Phe Val Arg Ala Lys 
 145                150                155                160
Gly Ser Gln Ser Gly Arg His Leu Gln Thr His Ser Asn Thr Ile Val 
                 165                170                175
Val Ser Leu Gln Ser Lys Leu Ala Ser Met Ser Asn Asp Phe Lys Ser 
             180                185                190
Val Leu Glu Val Arg Thr Glu Asn Leu Lys Gln Gln Arg Asn Arg Arg 
         195                200                205
Glu Gln Phe 
     210



<210> 9036
<211> 1507
<212> DNA
<213> Homo sapiens
<308> NM_003164
<400> 9036

ctcgaggcc  cgaaggccc  gacaccatg  cctgccggg  tcggaccca  gagtttctg  60
ctgcctgca  gtcgctgca  acccgtcag  atggaatcc  gacaaataa  ccagctttg  120
gtgctgtcc  acaacgcag  gaattcacc  tcatggcca  gcgcattgg  aaagacctt  180
gcaacacat  tgccaagct  gagaagctg  caatcttgg  aaagcgcaa  tccctcttt  240
atgataaag  agtggaaat  gaagagcta  catatatca  caaacagga  atcaatagc  300
tcaacaaac  aattgctca  ctccaggat  tcgtgagag  caagggcag  cagagtggc  360
ggcacctgc  gacccactc  aacaccatt  tggtctcct  gcagtcgaa  ctggcttct  420
tgtccaatg  cttcaaatc  gttttagaa  tgaggacag  gaacctgaa  cagcagagg  480
gccggagag  gcagttctc  cgggcacct  tgtcagccc  gccccttgc  cctaaccac  540
tgggcggtg  tgctgtggt  ctgggggca  agtcccatg  ctccaagga  gtcgccatc  600
acatgatgg  ctctcggac  agccagcag  tgcagctca  tgacgagca  gattcctac  660
tccagagtc  ggcagacac  atgcagaac  ttgagtcga  aattgttga  ttgggctcc  720
tctttcagc  gttggcaca  atggttaag  aacaggagg  aaccattca  aggatcgac  780
agaacgtgc  aggagccca  ctggacgtt  aggccgccc  ttcagagat  ctcaagtac  840
tccagtctg  cacctccaa  cggtggctc  tggtcaaaa  cttcctcat  ctcattgtc  900
tcttcatca  ctttgtggt  ttccttgct  gaaccctct  tactctgag  cactctgtt  960
gggtttggg  ccctcctgg  aaggcaagt  gccagtgct  ccactgagc  tgtgcaggg  1020
acttgggag  aaggccctg  ttccctgga  ctgctaaga  tgaccactg  ccctgatcc  1080
ccacccctt  cctctggcc  ccctgtcct  cccccacca  cctcaggcc  atgaaacac  1140
cagggttct  gatttgaac  ctgctgtga  gtgactgga  gggagcaga  gccagctgg  1200
ggccagtgg  ggaggttgt  tccactagg  gatttttat  aaccctctc  agcctctcc  1260
ggaaaggaa  cgttggcag  aaagggaga  gatgccctt  cccaccttc  tgtgagtga  1320
gagaggaag  agccccagg  accaatttt  ccaattgac  tctttcttc  tctttcacc  1380
tgtgaggca  ggagccctg  gcccttcag  tgcctgcac  acccctgac  ttggctgct  1440
gtgactcaa  ctgccaaat  tgctgcagc  cgttttctc  caattacag  aagactgtc  1500
gcctcca  1507



<210> 9037
<211> 301
<212> PRT
<213> Homo sapiens
<308> Q13190
<400> 9037

Met Ser Cys Arg Asp Arg Thr Gln Glu Phe Leu Ser Ala Cys Lys Ser 
  1               5                  10                  15
Leu Gln Thr Arg Gln Asn Gly Ile Gln Thr Asn Lys Pro Ala Leu Arg 
             20                  25                  30
Ala Val Arg Gln Arg Ser Glu Phe Thr Leu Met Ala Lys Arg Ile Gly 
         35                  40                  45
Lys Asp Leu Ser Asn Thr Phe Ala Lys Leu Glu Lys Leu Thr Ile Leu 
     50                  55                  60
Ala Lys Arg Lys Ser Leu Phe Asp Asp Lys Ala Val Glu Ile Glu Glu 
 65                  70                  75                  80
Leu Thr Tyr Ile Ile Lys Gln Asp Ile Asn Ser Leu Asn Lys Gln Ile 
                 85                  90                  95
Ala Gln Leu Gln Asp Phe Val Arg Ala Lys Gly Ser Gln Ser Gly Arg 
             100                105                110
His Leu Gln Thr His Ser Asn Thr Ile Val Val Ser Leu Gln Ser Lys 
         115                120                125
Leu Ala Ser Met Ser Asn Asp Phe Lys Ser Val Leu Glu Val Arg Thr 
     130                135                140
Glu Asn Leu Lys Gln Gln Arg Ser Arg Arg Glu Gln Phe Ser Arg Ala 
 145                150                155                160
Pro Val Ser Ala Leu Pro Leu Ala Pro Asn His Leu Gly Gly Gly Ala 
                 165                170                175
Val Val Leu Gly Ala Glu Ser His Ala Ser Lys Asp Val Ala Ile Asp 
             180                185                190
Met Met Asp Ser Arg Thr Ser Gln Gln Leu Gln Leu Ile Asp Glu Gln 
         195                200                205
Asp Ser Tyr Ile Gln Ser Arg Ala Asp Thr Met Gln Asn Ile Glu Ser 
     210                215                220
Thr Ile Val Glu Leu Gly Ser Ile Phe Gln Gln Leu Ala His Met Val 
 225                230                235                240
Lys Glu Gln Glu Glu Thr Ile Gln Arg Ile Asp Glu Asn Val Leu Gly 
                 245                250                255
Ala Gln Leu Asp Val Glu Ala Ala His Ser Glu Ile Leu Lys Tyr Phe 
             260                265                270
Gln Ser Val Thr Ser Asn Arg Trp Leu Met Val Lys Ile Phe Leu Ile 
         275                280                285
Leu Ile Val Phe Phe Ile Ile Phe Val Val Phe Leu Ala 
     290                295                300



<210> 9038
<211> 770
<212> DNA
<213> Rattus norvegicus
<308> U87971
<400> 9038

gtacgtgta  gtgacgtgg  ggctccagt  ctttggtcc  gcttccact  cttacaagt  60
cggcgagga  gcggcaacg  cctgaggag  gtagcggtg  cggtaggca  cagaagagt  120
cgaggttat  cgactcgat  atcccgcgg  aacgctacg  atctaagaa  acggatcag  180
gtgtctacc  gggtctctc  aagacacag  ttctgtccc  tgcaactgc  atcaatagc  240
gcagtgaca  cgctccttt  cccaccccg  tggccctgg  cccctcccc  cccgacact  300
tgtcctgcc  ggatcggac  caggagttc  tgtctgcct  caagtcgct  cagagccgt  360
agaatggaa  ccaaacaaa  aaaccagct  tgcacgcta  ccggcagtg  agcgagttt  420
ccctcatgg  caggcgcat  gggaaagat  tcagcaata  atttgccaa  ctggagaag  480
taacaatcc  ggcaaagcg  aagtccctc  ttgatgata  agcagtaga  attgaggaa  540
taacataca  catcaaaca  gacatcaat  gcctcaaca  acaaattgc  cagcttcaa  600
attttgtga  ggccaaggg  agccagagt  gccggcatc  gcagaccca  tccaacacc  660
ttgtagttt  attgcagtc  aaactggct  ccatgtcca  tgacttcaa  tctgttttg  720
aagtgagga  tgaaaatct  aaacagcag  ggaaccgtc  ggaacagttc  770



<210> 9039
<211> 211
<212> PRT
<213> Rattus norvegicus
<308> AAB93844
<400> 9039

Met Ile Pro Arg Lys Arg Tyr Gly Ser Lys Asn Thr Asp Gln Gly Val 
  1               5                  10                  15
Tyr Leu Gly Leu Ser Lys Thr Gln Val Leu Ser Pro Ala Thr Ala Ile 
             20                  25                  30
Asn Ser Ser Ser Asp Ile Ala Pro Leu Pro Thr Pro Val Ala Leu Val 
         35                  40                  45
Pro Ser Pro Pro Asp Thr Met Ser Cys Arg Asp Arg Thr Gln Glu Phe 
     50                  55                  60
Leu Ser Ala Cys Lys Ser Leu Gln Ser Arg Gln Asn Gly Ile Gln Thr 
 65                  70                  75                  80
Asn Lys Pro Ala Leu His Ala Thr Arg Gln Cys Ser Glu Phe Thr Leu 
                 85                  90                  95
Met Ala Arg Arg Ile Gly Lys Asp Leu Ser Asn Thr Phe Ala Lys Leu 
             100                105                110
Glu Lys Leu Thr Ile Leu Ala Lys Arg Lys Ser Leu Phe Asp Asp Lys 
         115                120                125
Ala Val Glu Ile Glu Glu Leu Thr Tyr Ile Ile Lys Gln Asp Ile Asn 
     130                135                140
Ser Leu Asn Lys Gln Ile Ala Gln Leu Gln Asp Phe Val Arg Ala Lys 
 145                150                155                160
Gly Ser Gln Ser Gly Arg His Leu Gln Thr His Ser Asn Thr Ile Val 
                 165                170                175
Val Ser Leu Gln Ser Lys Leu Ala Ser Met Ser Asn Asp Phe Lys Ser 
             180                185                190
Val Leu Glu Val Arg Thr Glu Asn Leu Lys Gln Gln Arg Asn Arg Arg 
         195                200                205
Glu Gln Phe 
     210



<210> 9040
<211> 1507
<212> DNA
<213> Homo sapiens
<308> NM_003164
<400> 9040

ctcgaggcc  cgaaggccc  gacaccatg  cctgccggg  tcggaccca  gagtttctg  60
ctgcctgca  gtcgctgca  acccgtcag  atggaatcc  gacaaataa  ccagctttg  120
gtgctgtcc  acaacgcag  gaattcacc  tcatggcca  gcgcattgg  aaagacctt  180
gcaacacat  tgccaagct  gagaagctg  caatcttgg  aaagcgcaa  tccctcttt  240
atgataaag  agtggaaat  gaagagcta  catatatca  caaacagga  atcaatagc  300
tcaacaaac  aattgctca  ctccaggat  tcgtgagag  caagggcag  cagagtggc  360
ggcacctgc  gacccactc  aacaccatt  tggtctcct  gcagtcgaa  ctggcttct  420
tgtccaatg  cttcaaatc  gttttagaa  tgaggacag  gaacctgaa  cagcagagg  480
gccggagag  gcagttctc  cgggcacct  tgtcagccc  gccccttgc  cctaaccac  540
tgggcggtg  tgctgtggt  ctgggggca  agtcccatg  ctccaagga  gtcgccatc  600
acatgatgg  ctctcggac  agccagcag  tgcagctca  tgacgagca  gattcctac  660
tccagagtc  ggcagacac  atgcagaac  ttgagtcga  aattgttga  ttgggctcc  720
tctttcagc  gttggcaca  atggttaag  aacaggagg  aaccattca  aggatcgac  780
agaacgtgc  aggagccca  ctggacgtt  aggccgccc  ttcagagat  ctcaagtac  840
tccagtctg  cacctccaa  cggtggctc  tggtcaaaa  cttcctcat  ctcattgtc  900
tcttcatca  ctttgtggt  ttccttgct  gaaccctct  tactctgag  cactctgtt  960
gggtttggg  ccctcctgg  aaggcaagt  gccagtgct  ccactgagc  tgtgcaggg  1020
acttgggag  aaggccctg  ttccctgga  ctgctaaga  tgaccactg  ccctgatcc  1080
ccacccctt  cctctggcc  ccctgtcct  cccccacca  cctcaggcc  atgaaacac  1140
cagggttct  gatttgaac  ctgctgtga  gtgactgga  gggagcaga  gccagctgg  1200
ggccagtgg  ggaggttgt  tccactagg  gatttttat  aaccctctc  agcctctcc  1260
ggaaaggaa  cgttggcag  aaagggaga  gatgccctt  cccaccttc  tgtgagtga  1320
gagaggaag  agccccagg  accaatttt  ccaattgac  tctttcttc  tctttcacc  1380
tgtgaggca  ggagccctg  gcccttcag  tgcctgcac  acccctgac  ttggctgct  1440
gtgactcaa  ctgccaaat  tgctgcagc  cgttttctc  caattacag  aagactgtc  1500
gcctcca  1507



<210> 9041
<211> 301
<212> PRT
<213> Homo sapiens
<308> Q13190
<400> 9041

Met Ser Cys Arg Asp Arg Thr Gln Glu Phe Leu Ser Ala Cys Lys Ser 
  1               5                  10                  15
Leu Gln Thr Arg Gln Asn Gly Ile Gln Thr Asn Lys Pro Ala Leu Arg 
             20                  25                  30
Ala Val Arg Gln Arg Ser Glu Phe Thr Leu Met Ala Lys Arg Ile Gly 
         35                  40                  45
Lys Asp Leu Ser Asn Thr Phe Ala Lys Leu Glu Lys Leu Thr Ile Leu 
     50                  55                  60
Ala Lys Arg Lys Ser Leu Phe Asp Asp Lys Ala Val Glu Ile Glu Glu 
 65                  70                  75                  80
Leu Thr Tyr Ile Ile Lys Gln Asp Ile Asn Ser Leu Asn Lys Gln Ile 
                 85                  90                  95
Ala Gln Leu Gln Asp Phe Val Arg Ala Lys Gly Ser Gln Ser Gly Arg 
             100                105                110
His Leu Gln Thr His Ser Asn Thr Ile Val Val Ser Leu Gln Ser Lys 
         115                120                125
Leu Ala Ser Met Ser Asn Asp Phe Lys Ser Val Leu Glu Val Arg Thr 
     130                135                140
Glu Asn Leu Lys Gln Gln Arg Ser Arg Arg Glu Gln Phe Ser Arg Ala 
 145                150                155                160
Pro Val Ser Ala Leu Pro Leu Ala Pro Asn His Leu Gly Gly Gly Ala 
                 165                170                175
Val Val Leu Gly Ala Glu Ser His Ala Ser Lys Asp Val Ala Ile Asp 
             180                185                190
Met Met Asp Ser Arg Thr Ser Gln Gln Leu Gln Leu Ile Asp Glu Gln 
         195                200                205
Asp Ser Tyr Ile Gln Ser Arg Ala Asp Thr Met Gln Asn Ile Glu Ser 
     210                215                220
Thr Ile Val Glu Leu Gly Ser Ile Phe Gln Gln Leu Ala His Met Val 
 225                230                235                240
Lys Glu Gln Glu Glu Thr Ile Gln Arg Ile Asp Glu Asn Val Leu Gly 
                 245                250                255
Ala Gln Leu Asp Val Glu Ala Ala His Ser Glu Ile Leu Lys Tyr Phe 
             260                265                270
Gln Ser Val Thr Ser Asn Arg Trp Leu Met Val Lys Ile Phe Leu Ile 
         275                280                285
Leu Ile Val Phe Phe Ile Ile Phe Val Val Phe Leu Ala 
     290                295                300



<210> 9042
<211> 1614
<212> DNA
<213> Rattus norvegicus
<308> U88958
<400> 9042

tactctctc  ctctctttc  gtctcttcc  cgctccctc  ctttctctc  tccctctgc  60
ttcccagtg  ataaagtct  tgtcgctcc  ggaacttgt  ggcaatgcc  atttttcag  120
tttcccccg  gttctctaa  ctaactatt  aaaggtctg  ggtcgcaaa  ggtttgact  180
aacgtagga  gggacttaa  ttgaacggc  gatatattt  actgatcct  gcggtgcaa  240
tagcttacc  ggtgcaggc  gtgagagca  caggcaagt  cgatgcagt  tttaagggc  300
tttcagact  tttgctcaa  ctgggtgac  gcatggcca  ctacccgca  ggcctggac  360
acaagacga  catcaagac  gtgtgcaca  actgggagg  tttccacag  tgcacggtc  420
cagctctta  ggattgcca  gaaggggcg  aagatatgt  ggataaact  agaaaagaa  480
cgaaaaacc  caatatcca  ggcagctta  tcgaactct  cggcagcgg  aacggggcg  540
cggggtccc  gctcccggc  ctttccgtg  tcctggtgt  tctctcggc  gctttagcg  600
cctggcttt  cttctgagc  cggggccgg  tcccccctc  gctcaccca  ccacactca  660
tccatgctc  cggaaatcg  gaggaagag  cattcgttc  ctaaggacg  tgtgattct  720
tgtgatatt  aaaacactc  tatgggatt  tgggaaatc  tgtttctct  ttttttttt  780
tttaatttt  ttttatttt  gttgagtcc  tgtgtttta  ttgccaaat  ttaccgatc  840
gtgagcaaa  caagcacag  caaaatcgg  cctcacctt  agtccgtct  cacacaaaa  900
taagaaaac  gcaaactca  ccccatttt  aattttgtt  ttaatttta  ttacttatt  960
atttattta  tttttggca  aagaatctc  ggaatggcc  tgggccacc  actatatta  1020
tcatgttga  aacatgaaa  atgatgggc  cctcctaat  agaaagcga  gagaggaga  1080
ggccagggg  atgagctca  gagtgatgc  cacgtgggg  gcatctggt  aataatcgc  1140
cacgtcttt  ttccacagt  ccttgtttt  atcatttcc  cagcacatt  ctcctccag  1200
aacgcgaaa  acacaagcg  gtgggttct  catttttaa  gataagaga  agaaagagg  1260
tgggtatag  aggacaggt  gtcagaaga  atgctgcta  ggtcacgag  ggccggttt  1320
acctgctat  gtcgtcgcc  ccttcagtt  cactgcctt  atgtcccct  ctctctctt  1380
ttttagctg  tacacatac  gtaatacct  aatatccaa  ggtatagtt  acaaggggg  1440
aatcaatgt  aaatctaaa  tagaattta  aaaaaaaag  ttttgacat  aaagagcct  1500
gattttaaa  aaaaagaga  agatgtaat  taaaaagtt  attataaat  aaattcagc  1560
aaaatttgc  acaaagtat  gagaagtat  aaataaaag  tattgtttg  aaaa  1614



<210> 9043
<211> 142
<212> PRT
<213> Rattus norvegicus
<308> AAB53415
<400> 9043

Met Gly Leu Lys Leu Asn Gly Arg Tyr Ile Ser Leu Ile Leu Ala Val 
  1               5                  10                  15
Gln Ile Ala Tyr Leu Val Gln Ala Val Arg Ala Ala Gly Lys Cys Asp 
             20                  25                  30
Ala Val Phe Lys Gly Phe Ser Asp Cys Leu Leu Lys Leu Gly Asp Ser 
         35                  40                  45
Met Ala Asn Tyr Pro Gln Gly Leu Asp Asp Lys Thr Asn Ile Lys Thr 
     50                  55                  60
Val Cys Thr Tyr Trp Glu Asp Phe His Ser Cys Thr Val Thr Ala Leu 
 65                  70                  75                  80
Thr Asp Cys Gln Glu Gly Ala Lys Asp Met Trp Asp Lys Leu Arg Lys 
                 85                  90                  95
Glu Ser Lys Asn Leu Asn Ile Gln Gly Ser Leu Phe Glu Leu Cys Gly 
             100                105                110
Ser Gly Asn Gly Ala Ala Gly Ser Leu Leu Pro Ala Leu Ser Val Leu 
         115                120                125
Leu Val Ser Leu Ser Ala Ala Leu Ala Thr Trp Leu Ser Phe 
     130                135                140



<210> 9044
<211> 1589
<212> DNA
<213> Homo sapiens
<308> AF136631
<400> 9044

gtctcttcc  cgctccctc  ctttctctc  tccctctgc  ttcccagtg  ataaagtct  60
tgtcgctcc  ggaacttgt  ggcaatgcc  attttttgg  tttcccccg  gttctctaa  120
ctaactatt  aaaggtctg  ggtcgcaaa  ggtttgact  aacgtagga  gggacttaa  180
ttgaacggc  gatatattt  actgatcct  gcggtgcaa  tagcgtatc  ggtgcaggc  240
gtgagagca  cgggcaagt  cgatgcggt  ttcaagggc  tttcggact  tttgctcaa  300
ctgggcgac  gcatggcca  ctacccgca  ggcctggac  acaagacga  catcaagac  360
gtgtgcaca  actgggagg  tttccacag  tgcacggtc  cagccctta  ggattgcca  420
gaaggggcg  aagatatgt  ggataaact  agaaaagaa  ccaaaaacc  caacatcca  480
ggcagctta  tcgaactct  cggcagcgg  aacggggcg  cggggtccc  gctcccggc  540
ttcccggtg  tcctggtgt  tctctcggc  gctttagcg  cctggcttt  cttctgagc  600
tggggccag  tccccccgc  cgcccaccc  cactcactc  atgctcccg  aaatcgaga  660
gaagatcca  tagttcttt  gggacgttg  gattctctg  gatgctgaa  acactcata  720
aggattgtg  gaaatcctg  ttctctttt  tatttcgtt  gatttcttg  gttttattt  780
ccaaatgtt  ccaatcagt  agcaagcaa  cacagccaa  atcggacct  agctttagt  840
cgtcttcac  cacaaataa  aaaacggca  acccacccc  ttttttaat  ttattatta  900
taatttttt  tgttggcaa  agaatctca  gaacggccc  gggccacct  ctatattaa  960
catgctagt  acatgaaaa  tgatgggct  ctcctaata  gaaggcgag  agaggagaa  1020
gccagggga  tgaattcaa  agagatgtc  acggccgaa  catacggtg  ataattcac  1080
ctcacgtcg  tcttccaca  tatcttgtt  tgatcattt  cactgcaca  ttctcctca  1140
gaaaagcga  aggacagac  gttggcttt  tgtttggag  ataggaggg  gagagggaa  1200
gggctgagg  aatctctgg  gtaagagta  aggcttcca  aagacatgc  gctatggtc  1260
ctgaggggt  agctttatc  gctgttgtt  atgcatccg  ccaagttca  tgcctttat  1320
ttccctcct  cctcttgtt  tagctgtta  acacacagt  atacctgaa  atccaacgg  1380
atagatcac  aggggggga  gttaaatgt  aatctaaaa  atagctaaa  aaagatttt  1440
acataaaag  gccttgatt  taaaaaaaa  agagagaga  atgtaattt  aaaagttta  1500
tataaatta  attcagcaa  aaaagattt  ctacaaagt  tagagaagt  taaaataaa  1560
gttattgtt  gaaaaaaaa  aaaaaaaaa  1589



<210> 9045
<211> 142
<212> PRT
<213> Homo sapiens
<308> NP_057672
<400> 9045

Met Gly Leu Lys Leu Asn Gly Arg Tyr Ile Ser Leu Ile Leu Ala Val 
  1               5                  10                  15
Gln Ile Ala Tyr Leu Val Gln Ala Val Arg Ala Ala Gly Lys Cys Asp 
             20                  25                  30
Ala Val Phe Lys Gly Phe Ser Asp Cys Leu Leu Lys Leu Gly Asp Ser 
         35                  40                  45
Met Ala Asn Tyr Pro Gln Gly Leu Asp Asp Lys Thr Asn Ile Lys Thr 
     50                  55                  60
Val Cys Thr Tyr Trp Glu Asp Phe His Ser Cys Thr Val Thr Ala Leu 
 65                  70                  75                  80
Thr Asp Cys Gln Glu Gly Ala Lys Asp Met Trp Asp Lys Leu Arg Lys 
                 85                  90                  95
Glu Ser Lys Asn Leu Asn Ile Gln Gly Ser Leu Phe Glu Leu Cys Gly 
             100                105                110
Ser Gly Asn Gly Ala Ala Gly Ser Leu Leu Pro Ala Phe Pro Val Leu 
         115                120                125
Leu Val Ser Leu Ser Ala Ala Leu Ala Thr Trp Leu Ser Phe 
     130                135                140



<210> 9046
<211> 1614
<212> DNA
<213> Rattus norvegicus
<308> U88958
<400> 9046

tactctctc  ctctctttc  gtctcttcc  cgctccctc  ctttctctc  tccctctgc  60
ttcccagtg  ataaagtct  tgtcgctcc  ggaacttgt  ggcaatgcc  atttttcag  120
tttcccccg  gttctctaa  ctaactatt  aaaggtctg  ggtcgcaaa  ggtttgact  180
aacgtagga  gggacttaa  ttgaacggc  gatatattt  actgatcct  gcggtgcaa  240
tagcttacc  ggtgcaggc  gtgagagca  caggcaagt  cgatgcagt  tttaagggc  300
tttcagact  tttgctcaa  ctgggtgac  gcatggcca  ctacccgca  ggcctggac  360
acaagacga  catcaagac  gtgtgcaca  actgggagg  tttccacag  tgcacggtc  420
cagctctta  ggattgcca  gaaggggcg  aagatatgt  ggataaact  agaaaagaa  480
cgaaaaacc  caatatcca  ggcagctta  tcgaactct  cggcagcgg  aacggggcg  540
cggggtccc  gctcccggc  ctttccgtg  tcctggtgt  tctctcggc  gctttagcg  600
cctggcttt  cttctgagc  cggggccgg  tcccccctc  gctcaccca  ccacactca  660
tccatgctc  cggaaatcg  gaggaagag  cattcgttc  ctaaggacg  tgtgattct  720
tgtgatatt  aaaacactc  tatgggatt  tgggaaatc  tgtttctct  ttttttttt  780
tttaatttt  ttttatttt  gttgagtcc  tgtgtttta  ttgccaaat  ttaccgatc  840
gtgagcaaa  caagcacag  caaaatcgg  cctcacctt  agtccgtct  cacacaaaa  900
taagaaaac  gcaaactca  ccccatttt  aattttgtt  ttaatttta  ttacttatt  960
atttattta  tttttggca  aagaatctc  ggaatggcc  tgggccacc  actatatta  1020
tcatgttga  aacatgaaa  atgatgggc  cctcctaat  agaaagcga  gagaggaga  1080
ggccagggg  atgagctca  gagtgatgc  cacgtgggg  gcatctggt  aataatcgc  1140
cacgtcttt  ttccacagt  ccttgtttt  atcatttcc  cagcacatt  ctcctccag  1200
aacgcgaaa  acacaagcg  gtgggttct  catttttaa  gataagaga  agaaagagg  1260
tgggtatag  aggacaggt  gtcagaaga  atgctgcta  ggtcacgag  ggccggttt  1320
acctgctat  gtcgtcgcc  ccttcagtt  cactgcctt  atgtcccct  ctctctctt  1380
ttttagctg  tacacatac  gtaatacct  aatatccaa  ggtatagtt  acaaggggg  1440
aatcaatgt  aaatctaaa  tagaattta  aaaaaaaag  ttttgacat  aaagagcct  1500
gattttaaa  aaaaagaga  agatgtaat  taaaaagtt  attataaat  aaattcagc  1560
aaaatttgc  acaaagtat  gagaagtat  aaataaaag  tattgtttg  aaaa  1614



<210> 9047
<211> 142
<212> PRT
<213> Rattus norvegicus
<308> AAB53415
<400> 9047

Met Gly Leu Lys Leu Asn Gly Arg Tyr Ile Ser Leu Ile Leu Ala Val 
  1               5                  10                  15
Gln Ile Ala Tyr Leu Val Gln Ala Val Arg Ala Ala Gly Lys Cys Asp 
             20                  25                  30
Ala Val Phe Lys Gly Phe Ser Asp Cys Leu Leu Lys Leu Gly Asp Ser 
         35                  40                  45
Met Ala Asn Tyr Pro Gln Gly Leu Asp Asp Lys Thr Asn Ile Lys Thr 
     50                  55                  60
Val Cys Thr Tyr Trp Glu Asp Phe His Ser Cys Thr Val Thr Ala Leu 
 65                  70                  75                  80
Thr Asp Cys Gln Glu Gly Ala Lys Asp Met Trp Asp Lys Leu Arg Lys 
                 85                  90                  95
Glu Ser Lys Asn Leu Asn Ile Gln Gly Ser Leu Phe Glu Leu Cys Gly 
             100                105                110
Ser Gly Asn Gly Ala Ala Gly Ser Leu Leu Pro Ala Leu Ser Val Leu 
         115                120                125
Leu Val Ser Leu Ser Ala Ala Leu Ala Thr Trp Leu Ser Phe 
     130                135                140



<210> 9048
<211> 1589
<212> DNA
<213> Homo sapiens
<308> AF136631
<400> 9048

gtctcttcc  cgctccctc  ctttctctc  tccctctgc  ttcccagtg  ataaagtct  60
tgtcgctcc  ggaacttgt  ggcaatgcc  attttttgg  tttcccccg  gttctctaa  120
ctaactatt  aaaggtctg  ggtcgcaaa  ggtttgact  aacgtagga  gggacttaa  180
ttgaacggc  gatatattt  actgatcct  gcggtgcaa  tagcgtatc  ggtgcaggc  240
gtgagagca  cgggcaagt  cgatgcggt  ttcaagggc  tttcggact  tttgctcaa  300
ctgggcgac  gcatggcca  ctacccgca  ggcctggac  acaagacga  catcaagac  360
gtgtgcaca  actgggagg  tttccacag  tgcacggtc  cagccctta  ggattgcca  420
gaaggggcg  aagatatgt  ggataaact  agaaaagaa  ccaaaaacc  caacatcca  480
ggcagctta  tcgaactct  cggcagcgg  aacggggcg  cggggtccc  gctcccggc  540
ttcccggtg  tcctggtgt  tctctcggc  gctttagcg  cctggcttt  cttctgagc  600
tggggccag  tccccccgc  cgcccaccc  cactcactc  atgctcccg  aaatcgaga  660
gaagatcca  tagttcttt  gggacgttg  gattctctg  gatgctgaa  acactcata  720
aggattgtg  gaaatcctg  ttctctttt  tatttcgtt  gatttcttg  gttttattt  780
ccaaatgtt  ccaatcagt  agcaagcaa  cacagccaa  atcggacct  agctttagt  840
cgtcttcac  cacaaataa  aaaacggca  acccacccc  ttttttaat  ttattatta  900
taatttttt  tgttggcaa  agaatctca  gaacggccc  gggccacct  ctatattaa  960
catgctagt  acatgaaaa  tgatgggct  ctcctaata  gaaggcgag  agaggagaa  1020
gccagggga  tgaattcaa  agagatgtc  acggccgaa  catacggtg  ataattcac  1080
ctcacgtcg  tcttccaca  tatcttgtt  tgatcattt  cactgcaca  ttctcctca  1140
gaaaagcga  aggacagac  gttggcttt  tgtttggag  ataggaggg  gagagggaa  1200
gggctgagg  aatctctgg  gtaagagta  aggcttcca  aagacatgc  gctatggtc  1260
ctgaggggt  agctttatc  gctgttgtt  atgcatccg  ccaagttca  tgcctttat  1320
ttccctcct  cctcttgtt  tagctgtta  acacacagt  atacctgaa  atccaacgg  1380
atagatcac  aggggggga  gttaaatgt  aatctaaaa  atagctaaa  aaagatttt  1440
acataaaag  gccttgatt  taaaaaaaa  agagagaga  atgtaattt  aaaagttta  1500
tataaatta  attcagcaa  aaaagattt  ctacaaagt  tagagaagt  taaaataaa  1560
gttattgtt  gaaaaaaaa  aaaaaaaaa  1589



<210> 9049
<211> 142
<212> PRT
<213> Homo sapiens
<308> NP_057672
<400> 9049

Met Gly Leu Lys Leu Asn Gly Arg Tyr Ile Ser Leu Ile Leu Ala Val 
  1               5                  10                  15
Gln Ile Ala Tyr Leu Val Gln Ala Val Arg Ala Ala Gly Lys Cys Asp 
             20                  25                  30
Ala Val Phe Lys Gly Phe Ser Asp Cys Leu Leu Lys Leu Gly Asp Ser 
         35                  40                  45
Met Ala Asn Tyr Pro Gln Gly Leu Asp Asp Lys Thr Asn Ile Lys Thr 
     50                  55                  60
Val Cys Thr Tyr Trp Glu Asp Phe His Ser Cys Thr Val Thr Ala Leu 
 65                  70                  75                  80
Thr Asp Cys Gln Glu Gly Ala Lys Asp Met Trp Asp Lys Leu Arg Lys 
                 85                  90                  95
Glu Ser Lys Asn Leu Asn Ile Gln Gly Ser Leu Phe Glu Leu Cys Gly 
             100                105                110
Ser Gly Asn Gly Ala Ala Gly Ser Leu Leu Pro Ala Phe Pro Val Leu 
         115                120                125
Leu Val Ser Leu Ser Ala Ala Leu Ala Thr Trp Leu Ser Phe 
     130                135                140



<210> 9050
<211> 1624
<212> DNA
<213> Rattus norvegicus
<308> U88986
<400> 9050

tcataggaa  aattcattc  ttagagtaa  atggagcgc  gctttttgc  aggggcccc  60
gcccctctg  ttttaccct  tcagaagtt  gaatgtcac  aagaagtga  gcccgggtg  120
acacttcta  actgcagaa  atcgccgca  atatgagca  cctgataga  aatctcgac  180
cccgggaac  tcattttga  ggagaggag  tggagtatg  tgcatctcc  ggagacccc  240
cggctcagg  agcgtgcat  ccattctct  ctatttaca  cactcaagg  tttaaggag  300
ccaacatcc  gatctacct  tctggctgt  ctgtaaaag  acaagtact  gaagtggag  360
gcttcacgt  gacctcgag  atgccaagt  tcaacctgt  caccatcga  ttaacacac  420
gggaattca  atggcaagt  aagaggaaa  tcaagcact  ccaagagtt  catagagag  480
tcctcaagt  caaagcctt  atccggatc  ccattccca  caaaagaca  acgtttaga  540
gacaaaatg  caaagaaga  cccagagaa  tgcccagtc  gccccgttc  tcagaaaat  600
caatccagg  ggagcagtt  tttggcagg  ggaagcaac  ggaagatta  ttgacaaaa  660
tactaaaaa  gcccatgta  agaaactat  atgccacga  agagttcct  gatgtaagc  720
aactgtctt  tatccatga  ttgggacca  agggcctgg  aggaatgat  atgaaaaga  780
ctgggggac  caggatacc  ggtgtgaat  gctgtggcc  tggaagagc  tgctaccgg  840
ggtcaaaga  gtggttgat  gtgaaagac  ctttcctgc  gtatatgaa  ccagacagc  900
gggcgatcg  cttcgtcct  cttgtagac  aagaattca  aatcaaagt  ggaaagaag  960
agacagaaa  gaaatatgg  cttcgaatt  ataatcttt  aaggacact  attttaaaa  1020
gtaacagct  cagacatgc  cggtggtgg  gaggcgcca  cgaggagtt  atccagaag  1080
acggcactg  cttcctcaa  gaccatcgc  tcggctcct  cgctgcggt  cacgagaac  1140
ttttagcta  atggtacgt  aacgccaaa  gttactttg  agatatcgc  aacgcaatg  1200
aaggggcaa  ggaagagat  tttatcaca  attggtggt  aagtccaga  atcttcctg  1260
agcgcccag  ggtggaagg  aaccgctgg  ggctggact  catcctcaa  cggaaagca  1320
aacaaggtg  gcggatttt  ataatgctt  acaaagagg  ggagctagc  ctcgggatc  1380
acagcgagt  caccaagcg  actttgatg  ggctgcacc  caacataaa  gtgatgaga  1440
acccagacc  tgtgtcctc  agtgtgtat  tgtgggctc  tcacgagaa  ctcgtcatt  1500
tcgaccaat  ggtggcgtt  gtgggtggg  ttgacctgg  ctatggacg  tgggatgac  1560
atgagcaca  actcacaga  gtgggcagt  tcaagcggg  cacctcagg  cagtctctg  1620
gctc  1624



<210> 9051
<211> 3609
<212> DNA
<213> Homo sapiens
<308> U38545
<400> 9051

ggcacgagg  gccctgaga  tccgccgcc  acgcgcagg  gctagcggc  ccttcgccc  60
gcagcccct  tgcttttac  ctgtccaaa  ttaacatgt  actgaaaaa  gagccacgg  120
taaatacct  tgcactgca  aaaattgct  ctgacatga  taatatcat  gaaaatctg  180
acacgcggg  actccactt  gagggagag  aggtagact  cgacgtgtc  cccagcgat  240
ccaagatac  agaagtgta  atccctttc  ctgctattt  taacactca  ggatttaag  300
agcctaata  acagacgta  ctctccggc  gtccaataa  agcacaagt  ctggaagtg  360
aacgcttca  atctacaac  agggtacca  gtattaatc  ttacactat  gaattaaca  420
atggggaat  taaatggca  gttaagagg  aattcaagc  ttttcaaga  tttcacaga  480
agctgctca  gtacaaagc  tttatccgc  tccccattc  cactagaag  cacacgttt  540
ggaggcaaa  cgtcagaga  gagcctcga  agatgccca  tttgccccg  tcatctgaa  600
acatgataa  agaagaaca  ttccttggt  gaagaaaac  actggaaga  tacttgaca  660
agatactaa  aatgcccat  tatagaaac  atcatgcca  aacagagtt  cttgatata  720
gccagctgt  tttcatcca  gatttggga  caaagggca  agaaggtat  ataatgaaa  780
gatctggag  acacagaat  ccaggcttg  attgctgtg  tcagggaag  gcctgctac  840
gatggtcaa  aagatggtt  atagtgaaa  attcctttt  attgtatat  aaaccagac  900
gcggtgcca  tgccttcgt  ctgctggta  acaaagaat  caaaattaa  gtggggaag  960
aggagacag  aacgaaata  ggaatccga  ttgataatc  ttcaaggac  cttatttta  1020
aatgcaaca  ctatagaca  gctcggtgg  ggggagggg  tatagaaga  ttcatccag  1080
aacatggca  caactttct  aaagatcat  gatttgggt  atatgctgc  atccaagag  1140
atgctttag  taaatggta  gttaatgcc  aaggatatt  tgaagatgt  gcaaatgca  1200
tggaagagg  aaatgaaga  atttttatc  cagactggt  gctgagtcc  gaaatcttc  1260
tgaaacgcc  agtggttga  ggaaatcgt  ggaggttgg  ctgcattct  aaacgaaaa  1320
cacaacaag  agtgaggat  ttcataatg  tctacaaag  ggtggaact  gctcttggc  1380
tcaatagtg  atacaccaa  aggactttg  tgcgtctac  tcccaacat  aaggtgatg  1440
gacacccgg  tcatgtgtc  tccaccgtc  atttgtggg  tcaccatga  aagcttgtc  1500
tcattgacc  atcggtggc  tttgtggga  ggattgacc  ggcctatgg  aggtgggac  1560
acaatgagc  cagactcac  gacgtgggc  gtgtgaagc  ggtcacttc  ggaccgtct  1620
tgggttccc  cccacctgc  gcaatggag  ctatggaat  cttaagact  aaagataaa  1680
atgagcctg  tcaaaacct  cccatccag  agagtattg  tgatgtgga  tcaaaactg  1740
aaggaatag  aaagccaag  aagttctcc  aatttagtc  ctacaagca  ctccacagg  1800
accacctgc  cgacgcaga  agcatcagc  gcattgaca  cacctccag  tattttaat  1860
actatagaa  tcatcacaa  ttaatccat  gtttaaaac  ccacttcaa  ctctttcac  1920
cgtccagtg  gtctgagca  ggactcact  gacctcatg  tgataccgg  tccatccgt  1980
gtttacaga  aggtgtggg  gagctgcat  gggaaacca  attctggca  ggaaaggac  2040
actgcaatt  cgtcttcaa  gactgggtt  aacttgata  accttttgc  gatttcatt  2100
acaggtact  cacgccccg  atgccctgg  atgacattg  ctctgcagt  cacgggaag  2160
cggctcgtg  tgtggcacg  cacttcatc  agcgctgga  cttcacaaa  attatgaaa  2220
caaaatatc  gtccctttc  tatcctttt  tgcttccaa  gtctcaaac  acagcccat  2280
agttgagat  tcaagtgcc  gggtctgtc  atgctaacg  acagttgct  cgctctgct  2340
ctgattggt  tgctggtat  aagtaccat  aagagtcca  ccacgccgc  tacgtccat  2400
tgatagaga  cagcaggca  tatatctat  tcgaaaacc  gtttttcat  agctgtgct  2460
atgacaaag  tgtgttcaa  aagataggc  atgccattg  ccagaggat  ctgaaagct  2520
acagggaaa  ccagaaata  cgggtatat  tcgtgatac  acttctgcc  gggttcgaa  2580
gagacattt  aaccggcgg  ggaaatgct  tacaggcaa  catgcactt  aactacaga  2640
ccatgtgca  aggagaaaa  tccatcctt  gacagttaa  agcagagct  ggtaatcag  2700
ggataaatt  catatcatt  tgtggtctt  gaacacatg  agagctcga  ggaaaccta  2760
taactgagc  tatctatgt  cacagcaag  tgttaattg  tgatgataa  actgttatt  2820
ttggctctg  caacataaa  gaccgcagc  tgctgggaa  gcgtgacag  gaaatggct  2880
tcattgtgc  agatacaga  actgttcct  cagtaatgg  tggaaaaga  taccaagct  2940
gccggtttg  ccgaggact  cggctacag  gctttaggg  tgtccttgg  tatcttgat  3000
acccaagtg  ggacattca  gatccagtg  gtgacaaat  cttcaagga  gtgtgggtt  3060
caacagcag  tcgaaatgc  acaatttat  acaaggttt  ccggtgcct  cccaatgat  3120
aagtacaca  tttaattca  ctgagagac  ttataaaca  gcccgtatt  gctaaggaa  3180
atcccattc  agctgagga  gaactgaag  agatccgtg  atttttggt  caattcccc  3240
tttatttct  gtctgaaga  agcctactg  cttctgttg  gaccaaaga  gccatagtg  3300
ccatggagg  ttggactta  gagatattc  ttggcagct  aaagacttc  accctggag  3360
ccacactgc  cacagtgac  tcctgggga  gtcatagcc  aagccaggc  tgacgcatt  3420
tcgtatcca  cccaaggac  ttttggaat  actggggag  gctgcagtc  cattgatgt  3480
aggactgta  acatcagca  gactttata  ttccttctg  ctaacttgt  aaaaggggg  3540
tgcattctt  ttggtagca  gtactctgt  gagtaaaac  catattcaa  ttccgctcg  3600
gccgaattc  3609



<210> 9052
<211> 1074
<212> PRT
<213> Homo sapiens
<308> Q13393
<400> 9052

Met Ser Leu Lys Asn Glu Pro Arg Val Asn Thr Ser Ala Leu Gln Lys 
  1               5                  10                  15
Ile Ala Ala Asp Met Ser Asn Ile Ile Glu Asn Leu Asp Thr Arg Glu 
             20                  25                  30
Leu His Phe Glu Gly Glu Glu Val Asp Tyr Asp Val Ser Pro Ser Asp 
         35                  40                  45
Pro Lys Ile Gln Glu Val Tyr Ile Pro Phe Ser Ala Ile Tyr Asn Thr 
     50                  55                  60
Gln Gly Phe Lys Glu Pro Asn Ile Gln Thr Tyr Leu Ser Gly Cys Pro 
 65                  70                  75                  80
Ile Lys Ala Gln Val Leu Glu Val Glu Arg Phe Thr Ser Thr Thr Arg 
                 85                  90                  95
Val Pro Ser Ile Asn Leu Tyr Thr Ile Glu Leu Thr His Gly Glu Phe 
             100                105                110
Lys Trp Gln Val Lys Arg Lys Phe Lys His Phe Gln Glu Phe His Arg 
         115                120                125
Glu Leu Leu Lys Tyr Lys Ala Phe Ile Arg Ile Pro Ile Pro Thr Arg 
     130                135                140
Arg His Thr Phe Arg Arg Gln Asn Val Arg Glu Glu Pro Arg Glu Met 
 145                150                155                160
Pro Ser Leu Pro Arg Ser Ser Glu Asn Met Ile Arg Glu Glu Gln Phe 
                 165                170                175
Leu Gly Arg Arg Lys Gln Leu Glu Asp Tyr Leu Thr Lys Ile Leu Lys 
             180                185                190
Met Pro Met Tyr Arg Asn Tyr His Ala Thr Thr Glu Phe Leu Asp Ile 
         195                200                205
Ser Gln Leu Ser Phe Ile His Asp Leu Gly Pro Lys Gly Ile Glu Gly 
     210                215                220
Met Ile Met Lys Arg Ser Gly Gly His Arg Ile Pro Gly Leu Asn Cys 
 225                230                235                240
Cys Gly Gln Gly Arg Ala Cys Tyr Arg Trp Ser Lys Arg Trp Leu Ile 
                 245                250                255
Val Lys Asp Ser Phe Leu Leu Tyr Met Lys Pro Asp Ser Gly Ala Ile 
             260                265                270
Ala Phe Val Leu Leu Val Asp Lys Glu Phe Lys Ile Lys Val Gly Lys 
         275                280                285
Lys Glu Thr Glu Thr Lys Tyr Gly Ile Arg Ile Asp Asn Leu Ser Arg 
     290                295                300
Thr Leu Ile Leu Lys Cys Asn Ser Tyr Arg His Ala Arg Trp Trp Gly 
 305                310                315                320
Gly Ala Ile Glu Glu Phe Ile Gln Lys His Gly Thr Asn Phe Leu Lys 
                 325                330                335
Asp His Arg Phe Gly Ser Tyr Ala Ala Ile Gln Glu Asn Ala Leu Ala 
             340                345                350
Lys Trp Tyr Val Asn Ala Lys Gly Tyr Phe Glu Asp Val Ala Asn Ala 
         355                360                365
Met Glu Glu Ala Asn Glu Glu Ile Phe Ile Thr Asp Trp Trp Leu Ser 
     370                375                380
Pro Glu Ile Phe Leu Lys Arg Pro Val Val Glu Gly Asn Arg Trp Arg 
 385                390                395                400
Leu Asp Cys Ile Leu Lys Arg Lys Ala Gln Gln Gly Val Arg Ile Phe 
                 405                410                415
Ile Met Leu Tyr Lys Glu Val Glu Leu Ala Leu Gly Ile Asn Ser Glu 
             420                425                430
Tyr Thr Lys Arg Thr Leu Met Arg Leu His Pro Asn Ile Lys Val Met 
         435                440                445
Arg His Pro Asp His Val Ser Ser Thr Val Tyr Leu Trp Ala His His 
     450                455                460
Glu Lys Leu Val Ile Ile Asp Gln Ser Val Ala Phe Val Gly Gly Ile 
 465                470                475                480
Asp Leu Ala Tyr Gly Arg Trp Asp Asp Asn Glu His Arg Leu Thr Asp 
                 485                490                495
Val Gly Ser Val Lys Arg Val Thr Ser Gly Pro Ser Leu Gly Ser Leu 
             500                505                510
Pro Pro Ala Ala Met Glu Ser Met Glu Ser Leu Arg Leu Lys Asp Lys 
         515                520                525
Asn Glu Pro Val Gln Asn Leu Pro Ile Gln Lys Ser Ile Asp Asp Val 
     530                535                540
Asp Ser Lys Leu Lys Gly Ile Gly Lys Pro Arg Lys Phe Ser Lys Phe 
 545                550                555                560
Ser Leu Tyr Lys Gln Leu His Arg His His Leu His Asp Ala Asp Ser 
                 565                570                575
Ile Ser Ser Ile Asp Ser Thr Ser Ser Tyr Phe Asn His Tyr Arg Ser 
             580                585                590
His His Asn Leu Ile His Gly Leu Lys Pro His Phe Lys Leu Phe His 
         595                600                605
Pro Ser Ser Glu Ser Glu Gln Gly Leu Thr Arg Pro His Ala Asp Thr 
     610                615                620
Gly Ser Ile Arg Ser Leu Gln Thr Gly Val Gly Glu Leu His Gly Glu 
 625                630                635                640
Thr Arg Phe Trp His Gly Lys Asp Tyr Cys Asn Phe Val Phe Lys Asp 
                 645                650                655
Trp Val Gln Leu Asp Lys Pro Phe Ala Asp Phe Ile Asp Arg Tyr Ser 
             660                665                670
Thr Pro Arg Met Pro Trp His Asp Ile Ala Ser Ala Val His Gly Lys 
         675                680                685
Ala Ala Arg Asp Val Ala Arg His Phe Ile Gln Arg Trp Asn Phe Thr 
     690                695                700
Lys Ile Met Lys Ser Lys Tyr Arg Ser Leu Ser Tyr Pro Phe Leu Leu 
 705                710                715                720
Pro Lys Ser Gln Thr Thr Ala His Glu Leu Arg Tyr Gln Val Pro Gly 
                 725                730                735
Ser Val His Ala Asn Val Gln Leu Leu Arg Ser Ala Ala Asp Trp Ser 
             740                745                750
Ala Gly Ile Lys Tyr His Glu Glu Ser Ile His Ala Ala Tyr Val His 
         755                760                765
Val Ile Glu Asn Ser Arg His Tyr Ile Tyr Ile Glu Asn Gln Phe Phe 
     770                775                780
Ile Ser Cys Ala Asp Asp Lys Val Val Phe Asn Lys Ile Gly Asp Ala 
 785                790                795                800
Ile Ala Gln Arg Ile Leu Lys Ala His Arg Glu Asn Gln Lys Tyr Arg 
                 805                810                815
Val Tyr Val Val Ile Pro Leu Leu Pro Gly Phe Glu Gly Asp Ile Ser 
             820                825                830
Thr Gly Gly Gly Asn Ala Leu Gln Ala Ile Met His Phe Asn Tyr Arg 
         835                840                845
Thr Met Cys Arg Gly Glu Asn Ser Ile Leu Gly Gln Leu Lys Ala Glu 
     850                855                860
Leu Gly Asn Gln Trp Ile Asn Tyr Ile Ser Phe Cys Gly Leu Arg Thr 
 865                870                875                880
His Ala Glu Leu Glu Gly Asn Leu Val Thr Glu Leu Ile Tyr Val His 
                 885                890                895
Ser Lys Leu Leu Ile Ala Asp Asp Asn Thr Val Ile Ile Gly Ser Ala 
             900                905                910
Asn Ile Asn Asp Arg Ser Met Leu Gly Lys Arg Asp Ser Glu Met Ala 
         915                920                925
Val Ile Val Gln Asp Thr Glu Thr Val Pro Ser Val Met Asp Gly Lys 
     930                935                940
Glu Tyr Gln Ala Gly Arg Phe Ala Arg Gly Leu Arg Leu Gln Cys Phe 
 945                950                955                960
Arg Val Val Leu Gly Tyr Leu Asp Asp Pro Ser Glu Asp Ile Gln Asp 
                 965                970                975
Pro Val Ser Asp Lys Phe Phe Lys Glu Val Trp Val Ser Thr Ala Ala 
             980                985                990
Arg Asn Ala Thr Ile Tyr Asp Lys Val Phe Arg Cys Leu Pro Asn Asp 
         995                1000                1005
Glu Val His Asn Leu Ile Gln Leu Arg Asp Phe Ile Asn Lys Pro Val 
     1010                1015                1020
Leu Ala Lys Glu Asp Pro Ile Arg Ala Glu Glu Glu Leu Lys Lys Ile 
 1025                1030                1035                1040
Arg Gly Phe Leu Val Gln Phe Pro Phe Tyr Phe Leu Ser Glu Glu Ser 
                 1045                1050                1055
Leu Leu Pro Ser Val Gly Thr Lys Glu Ala Ile Val Pro Met Glu Val 
             1060                1065                1070
Trp Thr 
         1075



<210> 9053
<211> 8216
<212> DNA
<213> Rattus norvegicus
<308> U89282
<400> 9053

gagctccgc  cctcccctt  cccagcctc  ccccttcgc  tctctaggg  gttggtttc  60
tttcagttc  ctttcttca  cctatccac  ggctgacct  ggccggttt  tgctccttg  120
tgcggagaa  caacgcgcc  ctcactgtg  acagctttt  cagtcccga  cgcaggcac  180
tagagattg  gctgccgct  tggagaaac  ctgtggtta  gtgcctgtc  acccagaca  240
cctctcctt  aagaatcgg  gcctgacca  gctctctga  atccaaccc  tggagaaaa  300
acatggaca  agatctgtc  acccagaca  cctgtcctt  gagaaccgg  gcctgacct  360
gctccctga  ctccagccc  tggagaaaa  acatggaca  agatctgtc  acccagaca  420
cctctcctc  gagaaccgg  gtctgacct  gctccctga  ctccagtcc  tggagaagc  480
atgtggaca  atgtctagt  acccagacg  cctctcttt  gagaaccga  gtcttgcta  540
cctcccgac  gtaaagaga  ctgtttcga  tggcccctt  ctccagtgt  ttcacagat  600
tcatacggc  caagctgat  tgcgtgacc  gaactttcg  aactgcctg  tccctgagc  660
tcctaccat  gaggctcca  gtttcttga  ggaactaga  cttccaact  gacccaggg  720
cctgaaatc  atgtctgct  cagctcgag  tcaggaagt  gctttgggt  agcggtgcg  780
ctcagaagg  aaggaattg  aggaagaaa  agaaagcgc  gaagtcccg  tgcctttgt  840
cagtctaag  ttgggggga  aagaagaag  agtggtggg  gcaccggtc  taaaactca  900
atctggaga  tctgactct  accctgaaa  cactgacca  atcctgcag  agaagaaga  960
ggctctctt  accttgctg  gctcagcta  ggcctcaag  gtgaatgtg  aagatgcct  1020
cgatcctac  cgggcatct  tccatgaag  ctgcagtgc  ctggccccc  tggaacctg  1080
gttcatcct  aaggcatct  tgtatgcta  gcagcagct  aacctccgg  acatagcca  1140
tatagtgtt  gccgtggct  ccctcttgc  agcctgccg  ccccatgta  gacggtatt  1200
ctctgccat  gttcacctg  cttcagact  gatccaggt  gccgagttc  accagagcc  1260
ggcagaagg  gatgagaag  agttggtgc  cctgcctgc  tgcctccgt  ctgccatga  1320
tgacaaatt  gcccagttt  atgagtacc  gctagcgaa  tacaaccca  ggaaacacc  1380
atccaagac  cgttcccgc  agccacccc  ccctcaaag  acaaaacct  cattttcag  1440
gagtgggaa  tgttttcca  agagcgttt  gccccttaa  aacgaacag  tttcgttcg  1500
agcagctta  aatgcagtg  cagagaaga  aaggctacc  aggttcact  tgaagaagt  1560
ggtagagca  ctgcatatc  atgagcctg  gcagcatgt  caggccctg  tgggctaca  1620
gtacccatc  accctagag  tcttttctc  gagtcatct  cctgggcca  gggactcta  1680
cagggctgg  caacggatg  agctccaaa  gccagagac  tgggagcgg  agctgagct  1740
acgtggaaa  agagcttct  tgtgggagg  actcataga  aatgggaaa  tccccttca  1800
ggccatgct  cggaacctg  gtaacctgc  gcggactgg  atcagtgcc  accaccatg  1860
actcgttct  cagagactc  agcatgaga  atctgtgat  cacagtcgg  agtttccat  1920
cagattcct  aatgctcac  actctctcg  tagactcga  gctcagctc  gaagtaaag  1980
atcgccctt  ccttccaat  caacattga  gaagcggat  atgattaga  actcaaaaa  2040
aatcaagag  cctgccaac  cgaggtacc  gtgcaccct  acgcagcgg  agcttcggg  2100
ggcaatggc  atcccggtg  tgtatgagc  tctcaagcg  gagaaactg  ggctgcaca  2160
ggccagaca  tggacctgt  accttgagt  gctggagcg  tatcgccag  ccctggaaa  2220
ggccgtgaa  atctctgta  agcacaacc  acccccgct  ccaggccga  ccctcttgg  2280
ctatctcac  gatgcaaat  ccaacagac  ttgtcccaa  agtcacttg  aagggcctc  2340
cctgaacta  gtgctgctg  tgatcggga  gatgatggc  cgggcggag  agacgacag  2400
ttggctgtg  gggacagga  ctgtgaaga  accagtact  acagccgac  aaggtatcc  2460
gaagactgc  atcaaactt  aggctcaag  ccaggagtt  gaagaaaat  atgagtggc  2520
cctggaaac  tttgagaag  acctgctat  tctggctgt  cgaaggacc  ctattgaca  2580
ggtcatcct  ttcggccaa  ggatggata  ggagctgct  aatgtagcc  aacagatta  2640
ctggcagca  gtgaattcc  agtgcctct  cgtcagtgt  ctcctacgg  aaatgcagt  2700
catgtcacc  aatttgaat  ccaatgatg  gacgctctc  ggctgcact  acgggatcc  2760
gaagttcat  gcggagcat  gagcctctc  tcttctgga  catgtgggc  aactagata  2820
gatattcaa  atccctcca  ccccaggaa  gacaaaggt  tcacctctc  ggccgctgg  2880
ggagaacaa  cctggtccc  tcgttccta  ttcccagca  ggatggcgc  acatccggc  2940
tttcatttc  tccactttc  gagacatgc  tggggaacg  gacttgctg  tgcgatctg  3000
tctgccagc  ctgcaggcc  gagcgttcc  ccaccgcat  agccttcac  ccattgacc  3060
gcgctgggg  atcacggag  aagagaccc  caggaacag  caactggaa  tgtgccttg  3120
ggaggtgga  aactctcag  tgttcgtgg  gatcctggg  tcccgctat  gctatactc  3180
ccccagcta  gatctgcct  accaccccc  ctttcactg  acccagcga  acccttcgg  3240
gcgctctgt  acagagatg  aggtgatgc  gttcctgaa  cgtggccaa  gctcggaac  3300
ctctgacca  gctctcatc  acttccgag  tcctggttt  cttagctct  tgccagatg  3360
ctggaaacc  gactttatt  ccgagtcag  agaggctgc  catcgggtc  cagaactga  3420
gagattcct  caggaacag  aagaggtta  ctgccgcag  tactcctgt  aatggggag  3480
cgtagcagc  ggccggccc  atactgggg  cctggagga  tttggacag  tggttctcc  3540
agatgtgtg  agcgtgatc  agaagcgtt  cctgcagcc  ggggcccag  tggagcagc  3600
aggatccat  tcagaagag  atttgatcc  ggccagctt  cagcagctg  agagcccac  3660
gagtcccgc  cggccacgc  ttcttcagg  taccgtgca  cagctgatg  tgccccacg  3720
gaggctgag  ctagtgatt  ggcaggcag  acagggaaa  actgccttc  tggcatccc  3780
tgtgtcggc  ctgaaggtt  ccgaccagc  caatgtggc  ccgttcgtt  tcttccact  3840
ttcagcagc  cgccctgac  agtgtcttg  tttcaacct  ctcagacgc  tctgtaccc  3900
tctgcatca  aaactggga  agccgagcg  tctccccag  acttacaga  gcctggtgt  3960
ggaactgca  cagaagctg  tcctcaaat  tgcccagtg  ctgcaacca  gccagactt  4020
ggtccttat  atcgacggg  cagataagt  ggtggacca  aatggacag  tgatttcag  4080
ctggatccc  aagtctctt  cgcggcgag  acacctggt  ctgagtgtg  ctagtgact  4140
aggcctggg  gagaccctt  agcaaagtc  gagtgctta  gtggtggcc  tggggtctt  4200
ggtcccgtc  tcaagggct  agcttgtga  agaagagct  gcactgtat  ggaaacggc  4260
ggaggagtc  ccttttaac  accagatgc  gctgctgct  gcaaagcag  ggtcaagcc  4320
gccactgta  ctgcacctc  tcactgact  cctgaggct  ttcacactg  acgaacagg  4380
gtctgagag  cttcgaacc  tgcccgcca  tctcccact  ctgctgcag  acatcctga  4440
caccttgga  caagagcat  gccataacg  ccttcctca  gctttgact  cccttgagg  4500
cacgcacag  ggtctgact  tggaccagc  gcatgcagt  ctgagcacg  ggttgactt  4560
gcccaagga  actaagagc  gggaagagg  agtggctgc  agtcacagt  gaaacctct  4620
ccccttggc  ccatttgcc  accttgtcc  gagtctacg  agtttacta  gcgagggcc  4680
cgtggagcg  cctggcgcc  gtctctgcc  ctctgatgg  cctctgagg  cagcagtta  4740
acgtcgcta  gggaaaagg  tggggctag  gaagactgc  catgtcctc  ttgcagctc  4800
cctctggaa  atgtgtgac  ctgatgcct  aggcacctt  cgaagttgc  ctcccgagg  4860
tctgaaaga  ttaccttac  acctgctcc  gagcgggaa  catggtctc  ttgcaaagt  4920
ccttaccaa  ctccatgtg  tggctgcat  tctggaagt  ggtctagtc  cggacctct  4980
ggaggctta  gagctctat  cttcttcaa  gcctgaagt  aaccagaag  tcccggagg  5040
agatgttgc  gtattccac  acttcctga  acaacaggc  tcactcctt  cccagtatc  5100
tttgctcct  ctccagcag  cagctagcc  gcctgaaga  tcacctgtt  gctgccagg  5160
ccccctgct  acccagcgg  ggcacaacc  gtgcatact  aaatggatt  ataaacccc  5220
gaccttgaa  ggtcagcaa  gcttgtctc  gccaatttc  tcatcccca  ctgctgtgg  5280
cttctctcc  aatgggcaa  gagcagctg  ggggactgc  ggtgggaca  tttacctgt  5340
gaacttgag  acctggcag  aggagaagg  tctggtgag  ggctgtgat  ggatttcct  5400
tttcgcgtt  ctgtcagac  ctgctcttt  ccttaccac  ttcgatggg  tcctggagc  5460
ttgggacct  caacatggt  gttgggtgt  ccagaccaa  gcccaccag  accaaatca  5520
tggctgctg  ctgagccca  accgccgcc  gctggccac  gtgtgtttg  gaggatacg  5580
aaagctgtg  gacacagtc  agggccagc  ggctttcca  tacacccat  ccaagtctc  5640
aaactgcat  accttccac  cagaggggc  ggtggtagc  acaggcaac  ggtctggca  5700
cgtgacctt  ttccaggca  atggactca  agtcaccaa  gaactaggg  gcccaggac  5760
ctctgttcg  acgctggca  tcagtgcac  cgggaaggt  gtggctcta  gccggatag  5820
tgggacagt  gagctgtgg  cctggcaag  gggcacacg  ctggcagcc  tccctgcac  5880
gtgtggcgg  gtctccacc  ttcttttct  gcatgctgg  ggccggttc  tgacggctg  5940
ggaagatgg  aaggctcag  tatggtcag  atttcttgg  cggcccagg  gttgcctgg  6000
ctctcttta  ctttctcct  cgctctctg  ggctctcaa  ccagacggt  accaggtgg  6060
tgttgggta  cgaggagat  gcattaaaa  ctacagaat  tcttcaggt  cccaggagg  6120
tcaatgcca  gagctaaat  tggcggtgt  tgcactggt  tggctgagt  ccagcgtct  6180
ggtgagtgg  gcagaagat  gctccctgc  tggctggat  ctcaggaga  actcccttc  6240
gtccctgtg  ctgtcatcc  tgtgccaga  gcctgtgct  gggctggct  cctcccagg  6300
gttcttggc  tctgcctca  aggacttca  ggtgcgact  tggccaaga  agctgctga  6360
acagccaca  gcagtagaa  agttgccct  tgcggctga  ctccgggga  acgaggggc  6420
ggtgtgctg  tgtagcttc  gcccggatg  acgcatctt  gccacagcg  gcagggatc  6480
gaatctcct  tgctgggac  tcaaggtag  ccaagcccc  ctcctgatt  acacgttct  6540
gtcctgtca  cgagactgg  tcactggct  tacgtggac  aaagacaac  tcctgatct  6600
ctgctctag  gatggctct  tgggactct  gaacccaga  gcaggacag  aacttggcc  6660
gttcccagg  caccagagt  ccgtgagcg  tgtggttgc  gtggaggaa  acattgtat  6720
tgtgagtcg  gatgggacc  tgaaagtgt  ggaccgtca  ggtgtggag  tgaccagca  6780
ccctgccca  tccggaccc  ttagccagt  tgcggctgc  ctggaaccc  gtccagctg  6840
acagcctgg  tcagagctt  tggtggtga  tgttggact  gatggggcc  caaagctgt  6900
gcatcccct  ttggtgtgc  aaatacata  cctgcaggg  cacagtggt  cagtcacag  6960
tgctgctgc  tcagaggcc  caggcctcc  gctgacctc  gacaatagc  ctgtacgac  7020
ctggcagat  cctaaggaa  cagatgata  ctgcaaacc  aggagttct  cggtcatca  7080
cgctgtggc  tgggcacca  atggttctc  ggtggtgtc  ggaaatgaa  ctggggaac  7140
aacgctgtg  cagaaagcg  aggctgtgg  tacggcacg  gctccaggc  gcgtcagtg  7200
cctgatctg  tgctccgca  atgcattct  tgttctcag  gctaatgaa  atgtcagtg  7260
gtggcaagt  gaactgagg  aaggttcaa  atgcaccaa  ttcagactt  atctgaaga  7320
agttctgca  gaggacttg  gagtcttga  aggtatggc  ctggcgcct  acggccagt  7380
tctcatttt  atgaaagag  atgtagaat  gctacagat  aagcccggg  ctactccat  7440
ttcgatctg  aggaggtat  cagtgcatt  ttctatact  tgcaccagc  aagactatg  7500
cctgtttta  ctgcagcag  gaaactctg  atctctttc  atcttggag  aggaggagt  7560
agggaagtt  gaaaagacc  tggacttca  tctgaactt  aataatcct  atgggtccc  7620
agtatcaat  actcaggct  aacctgagt  tgggtcctc  cttttgtgt  ctacctctg  7680
tgggatgct  tggaactta  ctgagtgta  cccagaagg  gagtgggtc  tagataaca  7740
ctggcagaa  aaatcaaga  accctaaaa  tcgaactcc  gggacagat  cgtccccag  7800
cttattctg  atggatagc  gggtagaac  cacacattt  aaggcacgg  agtgtaaaa  7860
gattcactt  ggctctgtc  cggccctcc  tgtgctgcc  ggattgctg  tgactgctt  7920
agaggacag  gatgttaag  tgtgggaga  acccagtat  cagctgctc  gcttgttcc  7980
atgtgaagg  ccggtgagc  gtctggaac  ttggatgga  cccagctct  ccctgcagc  8040
tgctgtggg  gatgcacaa  gaaacttgt  ttttctatc  tgggaatga  gatgaagaa  8100
caggacaaa  atggtgtca  cggatgatg  tcacctgaa  acaccagtg  ctatattct  8160
aataaggtt  taaaataaa  tgttggaag  tctaaaaaa  aaaaaaaaa  aaaaaa  8216



<210> 9054
<211> 2629
<212> PRT
<213> Rattus norvegicus
<308> AAB51690
<400> 9054

Met Glu Lys Leu Cys Gly Tyr Val Pro Val His Pro Asp Ile Leu Ser 
  1               5                  10                  15
Leu Lys Asn Arg Cys Leu Thr Met Leu Ser Asp Ile Gln Pro Leu Glu 
             20                  25                  30
Lys Ile His Gly Gln Arg Ser Val Asn Pro Asp Ile Leu Ser Leu Glu 
         35                  40                  45
Asn Arg Cys Leu Thr Leu Leu Pro Asp Leu Gln Pro Met Glu Lys Ile 
     50                  55                  60
His Gly Gln Arg Ser Val His Pro Asp Ile Leu Ser Ser Glu Asn Arg 
 65                  70                  75                  80
Cys Leu Thr Leu Leu Pro Asp Leu Gln Ser Leu Glu Lys Leu Cys Gly 
                 85                  90                  95
His Met Ser Ser His Pro Asp Val Leu Ser Leu Glu Asn Arg Cys Leu 
             100                105                110
Ala Thr Leu Pro Thr Val Lys Arg Thr Val Ser Ser Gly Pro Leu Leu 
         115                120                125
Gln Cys Leu His Arg Ser His Thr Ala Gln Ala Asp Leu Arg Asp Pro 
     130                135                140
Asn Phe Arg Asn Cys Leu Phe Pro Glu Pro Pro Thr Ile Glu Ala Pro 
 145                150                155                160
Cys Phe Leu Lys Glu Leu Asp Leu Pro Thr Gly Pro Arg Ala Leu Lys 
                 165                170                175
Ser Met Ser Ala Thr Ala Arg Val Gln Glu Val Ala Leu Gly Gln Arg 
             180                185                190
Cys Val Ser Glu Gly Lys Glu Leu Gln Glu Glu Lys Glu Ser Ala Glu 
         195                200                205
Val Pro Met Pro Leu Tyr Ser Leu Ser Leu Gly Gly Glu Glu Glu Glu 
     210                215                220
Val Val Gly Ala Pro Val Leu Lys Leu Thr Ser Gly Asp Ser Asp Ser 
 225                230                235                240
His Pro Glu Thr Thr Asp Gln Ile Leu Gln Glu Lys Lys Met Ala Leu 
                 245                250                255
Leu Thr Leu Leu Cys Ser Ala Met Ala Ser Ser Val Asn Val Lys Asp 
             260                265                270
Ala Ser Asp Pro Thr Arg Ala Ser Ile His Glu Val Cys Ser Ala Leu 
         275                280                285
Ala Pro Leu Glu Pro Glu Phe Ile Leu Lys Ala Ser Leu Tyr Ala Arg 
     290                295                300
Gln Gln Leu Asn Leu Arg Asp Ile Ala Asn Ile Val Leu Ala Val Ala 
 305                310                315                320
Ala Leu Leu Pro Ala Cys Arg Pro His Val Arg Arg Tyr Tyr Ser Ala 
                 325                330                335
Ile Val His Leu Pro Ser Asp Trp Ile Gln Val Ala Glu Phe Tyr Gln 
             340                345                350
Ser Leu Ala Glu Gly Asp Glu Lys Lys Leu Val Pro Leu Pro Ala Cys 
         355                360                365
Leu Arg Ala Ala Met Thr Asp Lys Phe Ala Gln Phe Asp Glu Tyr Gln 
     370                375                380
Leu Ala Lys Tyr Asn Pro Arg Lys His Arg Ser Lys Thr Arg Ser Arg 
 385                390                395                400
Gln Pro Pro Arg Pro Gln Arg Thr Lys Pro Pro Phe Ser Glu Ser Gly 
                 405                410                415
Lys Cys Phe Pro Lys Ser Val Trp Pro Leu Lys Asn Glu Gln Ile Ser 
             420                425                430
Phe Glu Ala Ala Tyr Asn Ala Val Ser Glu Lys Lys Arg Leu Pro Arg 
         435                440                445
Phe Thr Leu Lys Lys Leu Val Glu Gln Leu His Ile His Glu Pro Ala 
     450                455                460
Gln His Val Gln Ala Leu Leu Gly Tyr Arg Tyr Pro Ser Thr Leu Glu 
 465                470                475                480
Leu Phe Ser Arg Ser His Leu Pro Gly Pro Trp Asp Ser Ser Arg Ala 
                 485                490                495
Gly Gln Arg Met Lys Leu Gln Arg Pro Glu Thr Trp Glu Arg Glu Leu 
             500                505                510
Ser Leu Arg Gly Asn Arg Ala Ser Val Trp Glu Glu Leu Ile Asp Asn 
         515                520                525
Gly Lys Leu Pro Phe Met Ala Met Leu Arg Asn Leu Cys Asn Leu Leu 
     530                535                540
Arg Thr Gly Ile Ser Ala His His His Glu Leu Val Leu Gln Arg Leu 
 545                550                555                560
Gln His Glu Lys Ser Val Ile His Ser Arg Gln Phe Pro Phe Arg Phe 
                 565                570                575
Leu Asn Ala His Asp Ser Leu Asp Arg Leu Glu Ala Gln Leu Arg Ser 
             580                585                590
Lys Ala Ser Pro Phe Pro Ser Asn Thr Thr Leu Met Lys Arg Ile Met 
         595                600                605
Ile Arg Asn Ser Lys Lys Ile Lys Arg Pro Ala Asn Pro Arg Tyr Leu 
     610                615                620
Cys Thr Leu Thr Gln Arg Gln Leu Arg Ala Ala Met Ala Ile Pro Val 
 625                630                635                640
Met Tyr Glu His Leu Lys Arg Glu Lys Leu Arg Leu His Lys Ala Arg 
                 645                650                655
Gln Trp Thr Cys Asp Leu Glu Leu Leu Glu Arg Tyr Arg Gln Ala Leu 
             660                665                670
Glu Thr Ala Val Asn Ile Ser Val Lys His Asn Leu Pro Pro Leu Pro 
         675                680                685
Gly Arg Thr Leu Leu Val Tyr Leu Thr Asp Ala Asn Ala Asn Arg Leu 
     690                695                700
Cys Pro Lys Ser His Leu Gln Gly Pro Pro Leu Asn Tyr Val Leu Leu 
 705                710                715                720
Leu Ile Gly Met Met Met Ala Arg Ala Glu Gln Thr Thr Val Trp Leu 
                 725                730                735
Cys Gly Thr Gly Thr Val Lys Thr Pro Val Leu Thr Ala Asp Glu Gly 
             740                745                750
Ile Leu Lys Thr Ala Ile Lys Leu Gln Ala Gln Val Gln Glu Leu Glu 
         755                760                765
Glu Asn Asp Glu Trp Pro Leu Glu Thr Phe Glu Lys Tyr Leu Leu Ser 
     770                775                780
Leu Ala Val Arg Arg Thr Pro Ile Asp Arg Val Ile Leu Phe Gly Gln 
 785                790                795                800
Arg Met Asp Thr Glu Leu Leu Asn Val Ala Lys Gln Ile Ile Trp Gln 
                 805                810                815
His Val Asn Ser Lys Cys Leu Phe Val Ser Val Leu Leu Arg Lys Met 
             820                825                830
Gln Tyr Met Ser Pro Asn Leu Asn Pro Asn Asp Val Thr Leu Ser Gly 
         835                840                845
Cys Thr Asp Gly Ile Leu Lys Phe Ile Ala Glu His Gly Ala Ser Arg 
     850                855                860
Leu Leu Glu His Val Gly Gln Leu Asp Lys Ile Phe Lys Ile Pro Pro 
 865                870                875                880
Pro Pro Gly Lys Thr Lys Val Ser Pro Leu Arg Pro Leu Glu Glu Asn 
                 885                890                895
Asn Pro Gly Pro Phe Val Pro Ile Ser Gln His Gly Trp Arg Asn Ile 
             900                905                910
Arg Leu Phe Ile Ser Ser Thr Phe Arg Asp Met His Gly Glu Arg Asp 
         915                920                925
Leu Leu Met Arg Ser Val Leu Pro Ala Leu Gln Ala Arg Ala Phe Pro 
     930                935                940
His Arg Ile Ser Leu His Ala Ile Asp Leu Arg Trp Gly Ile Thr Glu 
 945                950                955                960
Glu Glu Thr Arg Arg Asn Arg Gln Leu Glu Val Cys Leu Gly Glu Val 
                 965                970                975
Glu Asn Ser Gln Leu Phe Val Gly Ile Leu Gly Ser Arg Tyr Gly Tyr 
             980                985                990
Thr Pro Pro Ser Tyr Asp Leu Pro Asp His Pro His Phe His Trp Thr 
         995                1000                1005
Gln Arg Tyr Pro Ser Gly Arg Ser Val Thr Glu Met Glu Val Met Gln 
     1010                1015                1020
Phe Leu Asn Arg Gly Gln Arg Ser Glu Pro Ser Asp Gln Ala Leu Ile 
 1025                1030                1035                1040
Tyr Phe Arg Asp Pro Gly Phe Leu Ser Ser Val Pro Asp Val Trp Lys 
                 1045                1050                1055
Pro Asp Phe Ile Ser Glu Ser Glu Glu Ala Ala His Arg Val Ser Glu 
             1060                1065                1070
Leu Lys Arg Phe Leu Gln Glu Gln Lys Glu Val Thr Cys Arg Arg Tyr 
         1075                1080                1085
Ser Cys Glu Trp Gly Gly Val Ala Ala Gly Arg Pro Tyr Thr Gly Gly 
     1090                1095                1100
Leu Glu Glu Phe Gly Gln Leu Val Leu Gln Asp Val Trp Ser Val Ile 
 1105                1110                1115                1120
Gln Lys Arg Tyr Leu Gln Pro Gly Ala Gln Leu Glu Gln Pro Gly Ser 
                 1125                1130                1135
Ile Ser Glu Glu Asp Leu Ile Gln Ala Ser Phe Gln Gln Leu Lys Ser 
             1140                1145                1150
Pro Pro Ser Pro Ala Arg Pro Arg Leu Leu Gln Asp Thr Val Gln Gln 
         1155                1160                1165
Leu Met Leu Pro His Gly Arg Leu Ser Leu Val Ile Gly Gln Ala Gly 
     1170                1175                1180
Gln Gly Lys Thr Ala Phe Leu Ala Ser Leu Val Ser Ala Leu Lys Val 
 1185                1190                1195                1200
Pro Asp Gln Pro Asn Val Ala Pro Phe Val Phe Phe His Phe Ser Ala 
                 1205                1210                1215
Ala Arg Pro Asp Gln Cys Leu Ala Phe Asn Leu Leu Arg Arg Leu Cys 
             1220                1225                1230
Thr His Leu His Gln Lys Leu Gly Glu Pro Ser Ala Leu Pro Ser Thr 
         1235                1240                1245
Tyr Arg Gly Leu Val Trp Glu Leu Gln Gln Lys Leu Leu Leu Lys Ser 
     1250                1255                1260
Ala Gln Trp Leu Gln Pro Gly Gln Thr Leu Val Leu Ile Ile Asp Gly 
 1265                1270                1275                1280
Ala Asp Lys Leu Val Asp His Asn Gly Gln Leu Ile Ser Asp Trp Ile 
                 1285                1290                1295
Pro Lys Ser Leu Pro Arg Arg Val His Leu Val Leu Ser Val Ser Ser 
             1300                1305                1310
Asp Ser Gly Leu Gly Glu Thr Leu Gln Gln Ser Gln Ser Ala Tyr Val 
         1315                1320                1325
Val Ala Leu Gly Ser Leu Val Pro Ser Ser Arg Ala Gln Leu Val Arg 
     1330                1335                1340
Glu Glu Leu Ala Leu Tyr Gly Lys Arg Leu Glu Glu Ser Pro Phe Asn 
 1345                1350                1355                1360
Asn Gln Met Arg Leu Leu Leu Ala Lys Gln Gly Ser Ser Leu Pro Leu 
                 1365                1370                1375
Tyr Leu His Leu Val Thr Asp Tyr Leu Arg Leu Phe Thr Leu Tyr Glu 
             1380                1385                1390
Gln Val Ser Glu Arg Leu Arg Thr Leu Pro Ala Thr Leu Pro Leu Leu 
         1395                1400                1405
Leu Gln His Ile Leu Ser Thr Leu Glu Gln Glu His Gly His Asn Val 
     1410                1415                1420
Leu Pro Gln Ala Leu Thr Ala Leu Glu Val Thr His Ser Gly Leu Thr 
 1425                1430                1435                1440
Val Asp Gln Leu His Ala Val Leu Ser Thr Trp Leu Thr Leu Pro Lys 
                 1445                1450                1455
Glu Thr Lys Ser Trp Glu Glu Ala Val Ala Ala Ser His Ser Gly Asn 
             1460                1465                1470
Leu Tyr Pro Leu Ala Pro Phe Ala Tyr Leu Val Gln Ser Leu Arg Ser 
         1475                1480                1485
Leu Leu Gly Glu Gly Pro Val Glu Arg Pro Gly Ala Arg Leu Cys Leu 
     1490                1495                1500
Ser Asp Gly Pro Leu Arg Thr Ala Val Lys Arg Arg Tyr Gly Lys Arg 
 1505                1510                1515                1520
Leu Gly Leu Glu Lys Thr Ala His Val Leu Ile Ala Ala His Leu Trp 
                 1525                1530                1535
Lys Met Cys Asp Pro Asp Ala Ser Gly Thr Phe Arg Ser Cys Pro Pro 
             1540                1545                1550
Glu Ala Leu Lys Asp Leu Pro Tyr His Leu Leu Gln Ser Gly Asn His 
         1555                1560                1565
Gly Leu Leu Ala Lys Phe Leu Thr Asn Leu His Val Val Ala Ala Tyr 
     1570                1575                1580
Leu Glu Val Gly Leu Val Pro Asp Leu Leu Glu Ala Tyr Glu Leu Tyr 
 1585                1590                1595                1600
Ala Ser Ser Lys Pro Glu Val Asn Gln Lys Leu Pro Glu Ala Asp Val 
                 1605                1610                1615
Ala Val Phe His Asn Phe Leu Lys Gln Gln Ala Ser Leu Leu Thr Gln 
             1620                1625                1630
Tyr Pro Leu Leu Leu Leu Gln Gln Ala Ala Ser Gln Pro Glu Glu Ser 
         1635                1640                1645
Pro Val Cys Cys Gln Ala Pro Leu Leu Thr Gln Arg Trp His Asn Gln 
     1650                1655                1660
Cys Ile Leu Lys Trp Ile Asn Lys Pro Gln Thr Leu Lys Gly Gln Gln 
 1665                1670                1675                1680
Ser Leu Ser Leu Pro Ile Ser Ser Ser Pro Thr Ala Val Ala Phe Ser 
                 1685                1690                1695
Pro Asn Gly Gln Arg Ala Ala Val Gly Thr Ala Gly Gly Thr Ile Tyr 
             1700                1705                1710
Leu Leu Asn Leu Arg Thr Trp Gln Glu Glu Lys Ala Leu Val Ser Gly 
         1715                1720                1725
Cys Asp Gly Ile Ser Ser Phe Ala Phe Leu Ser Asp Thr Ala Leu Phe 
     1730                1735                1740
Leu Thr Thr Phe Asp Gly Leu Leu Glu Leu Trp Asp Leu Gln His Gly 
 1745                1750                1755                1760
Cys Trp Val Phe Gln Thr Lys Ala His Gln Tyr Gln Ile Thr Gly Cys 
                 1765                1770                1775
Cys Leu Ser Pro Asp Arg Arg Leu Leu Ala Thr Val Cys Leu Gly Gly 
             1780                1785                1790
Tyr Val Lys Leu Trp Asp Thr Val Gln Gly Gln Leu Ala Phe Gln Tyr 
         1795                1800                1805
Thr His Pro Lys Ser Leu Asn Cys Ile Thr Phe His Pro Glu Gly Gln 
     1810                1815                1820
Val Val Ala Thr Gly Asn Trp Ser Gly Ile Val Thr Phe Phe Gln Ala 
 1825                1830                1835                1840
Asp Gly Leu Lys Val Thr Lys Glu Leu Gly Gly Pro Gly Pro Ser Val 
                 1845                1850                1855
Arg Thr Leu Ala Phe Ser Ala Pro Gly Lys Val Val Ala Leu Gly Arg 
             1860                1865                1870
Ile Asp Gly Thr Val Glu Leu Trp Ala Trp Gln Glu Gly Thr Arg Leu 
         1875                1880                1885
Ala Ala Phe Pro Ala Gln Cys Gly Gly Val Ser Thr Val Leu Phe Leu 
     1890                1895                1900
His Ala Gly Gly Arg Phe Leu Thr Ala Gly Glu Asp Gly Lys Ala Gln 
 1905                1910                1915                1920
Leu Trp Ser Gly Phe Leu Gly Arg Pro Arg Gly Cys Leu Gly Ser Leu 
                 1925                1930                1935
Tyr Leu Ser Pro Ala Leu Ser Val Ala Leu Asn Pro Asp Gly Asp Gln 
             1940                1945                1950
Val Ala Val Gly Tyr Arg Gly Asp Gly Ile Lys Ile Tyr Arg Ile Ser 
         1955                1960                1965
Ser Gly Pro Gln Glu Ala Gln Cys Gln Glu Leu Asn Val Ala Val Ser 
     1970                1975                1980
Ala Leu Val Trp Leu Ser Pro Ser Val Leu Val Ser Gly Ala Glu Asp 
 1985                1990                1995                2000
Gly Ser Leu His Gly Trp Met Leu Arg Arg Asn Ser Leu Gln Ser Leu 
                 2005                2010                2015
Trp Leu Ser Ser Val Cys Gln Lys Pro Val Leu Gly Leu Ala Ala Ser 
             2020                2025                2030
Gln Glu Phe Leu Ala Ser Ala Ser Glu Asp Phe Thr Val Arg Leu Trp 
         2035                2040                2045
Pro Arg Gln Leu Leu Thr Gln Pro His Ala Val Glu Glu Leu Pro Cys 
     2050                2055                2060
Ala Ala Glu Leu Arg Gly His Glu Gly Pro Val Cys Cys Cys Ser Phe 
 2065                2070                2075                2080
Ser Pro Asp Gly Arg Ile Leu Ala Thr Ala Gly Arg Asp Arg Asn Leu 
                 2085                2090                2095
Leu Cys Trp Asp Val Lys Val Ala Gln Ala Pro Leu Leu Ile His Thr 
             2100                2105                2110
Phe Ser Ser Cys His Arg Asp Trp Ile Thr Gly Cys Thr Trp Thr Lys 
         2115                2120                2125
Asp Asn Ile Leu Ile Ser Cys Ser Ser Asp Gly Ser Val Gly Leu Trp 
     2130                2135                2140
Asn Pro Glu Ala Gly Gln Gln Leu Gly Gln Phe Pro Gly His Gln Ser 
 2145                2150                2155                2160
Ala Val Ser Ala Val Val Ala Val Glu Glu His Ile Val Ser Val Ser 
                 2165                2170                2175
Arg Asp Gly Thr Leu Lys Val Trp Asp Arg Gln Gly Val Glu Leu Thr 
             2180                2185                2190
Ser Ile Pro Ala His Ser Gly Pro Ile Ser Gln Cys Ala Ala Ala Leu 
         2195                2200                2205
Glu Pro Arg Pro Ala Gly Gln Pro Gly Ser Glu Leu Met Val Val Thr 
     2210                2215                2220
Val Gly Leu Asp Gly Ala Thr Lys Leu Trp His Pro Leu Leu Val Cys 
 2225                2230                2235                2240
Gln Ile His Thr Leu Gln Gly His Ser Gly Pro Val Thr Ala Ala Ala 
                 2245                2250                2255
Ala Ser Glu Ala Ser Gly Leu Leu Leu Thr Ser Asp Asn Ser Ser Val 
             2260                2265                2270
Arg Leu Trp Gln Ile Pro Lys Glu Ala Asp Asp Thr Cys Lys Pro Arg 
         2275                2280                2285
Ser Ser Ala Val Ile Thr Ala Val Ala Trp Ala Pro Asp Gly Ser Leu 
     2290                2295                2300
Val Val Ser Gly Asn Glu Ala Gly Glu Leu Thr Leu Trp Gln Lys Ala 
 2305                2310                2315                2320
Gln Ala Val Ala Thr Ala Arg Ala Pro Gly Arg Val Ser Asp Leu Ile 
                 2325                2330                2335
Trp Cys Ser Ala Asn Ala Phe Phe Val Leu Ser Ala Asn Glu Asn Val 
             2340                2345                2350
Ser Glu Trp Gln Val Glu Leu Arg Lys Gly Ser Thr Cys Thr Asn Phe 
         2355                2360                2365
Arg Leu Tyr Leu Lys Arg Val Leu Gln Glu Asp Leu Gly Val Leu Thr 
     2370                2375                2380
Gly Met Ala Leu Ala Pro Asp Gly Gln Ser Leu Ile Leu Met Lys Glu 
 2385                2390                2395                2400
Asp Val Glu Leu Leu Gln Met Lys Pro Gly Ser Thr Pro Ser Ser Ile 
                 2405                2410                2415
Cys Arg Arg Tyr Ala Val His Ser Ser Ile Leu Cys Thr Ser Lys Asp 
             2420                2425                2430
Tyr Gly Leu Phe Tyr Leu Gln Gln Gly Asn Ser Gly Ser Leu Ser Ile 
         2435                2440                2445
Leu Glu Gln Glu Glu Ser Gly Lys Phe Glu Lys Thr Leu Asp Phe Asn 
     2450                2455                2460
Leu Asn Leu Asn Asn Pro Asn Gly Ser Pro Val Ser Ile Thr Gln Ala 
 2465                2470                2475                2480
Glu Pro Glu Ser Gly Ser Ser Leu Leu Cys Ala Thr Ser Asp Gly Met 
                 2485                2490                2495
Leu Trp Asn Leu Ser Glu Cys Thr Pro Glu Gly Glu Trp Val Val Asp 
             2500                2505                2510
Asn Ile Trp Gln Lys Lys Ser Arg Asn Pro Lys Ser Arg Thr Pro Gly 
         2515                2520                2525
Thr Asp Ser Ser Pro Gly Leu Phe Cys Met Asp Ser Trp Val Glu Pro 
     2530                2535                2540
Thr His Leu Lys Ala Arg Gln Cys Lys Lys Ile His Leu Gly Ser Val 
 2545                2550                2555                2560
Thr Ala Leu His Val Leu Pro Gly Leu Leu Val Thr Ala Ser Glu Asp 
                 2565                2570                2575
Arg Asp Val Lys Leu Trp Glu Arg Pro Ser Met Gln Leu Leu Gly Leu 
             2580                2585                2590
Phe Arg Cys Glu Gly Pro Val Ser Cys Leu Glu Pro Trp Met Glu Pro 
         2595                2600                2605
Ser Ser Pro Leu Gln Leu Ala Val Gly Asp Ala Gln Gly Asn Leu Tyr 
     2610                2615                2620
Phe Leu Ser Trp Glu 
 2625



<210> 9055
<211> 8665
<212> DNA
<213> Homo sapiens
<308> U86136
<400> 9055

ggtaccggt  cggaattcc  gggtcgacc  acgcgtccg  aatcggacg  cccaggcat  60
tacaagctg  gtttcagcc  tggaaaaac  ccatgggca  gtgtctgcc  atccagaca  120
cctctcctt  gagaaccgg  gcctggcta  gctccctga  ttacagccc  tggagaaac  180
acatcagca  gtatctacc  actcagata  cctctcctt  aagaaccag  gcctagcca  240
gcttcctga  ctgaagacc  tggaaaaac  acatggata  gtgtctgcc  acccagaca  300
cctctcctt  gagaaccag  gcctggcca  actttctga  ctgaagacc  tggagaaac  360
acatggaca  gtttctgcc  acccagaca  cctctcctt  gagaaccgg  gcctggcca  420
cctccctag  ctaaagagc  ctgtgtctg  cagcccctt  ttccagagt  tacagatat  480
tcacatgac  caagctgat  tgtaccgtg  gaacaacag  aattgcctg  tctctgagc  540
tccaagttg  agggctcag  atttctcta  gggactaga  ctttcaacc  gccctatag  600
cctgaaatc  atctctgcc  cagagacag  tcaggaagc  actttgggt  gttggtttg  660
ttcagaaga  aagaaaggg  cagagaccc  aatgccttc  tatagtctg  gcttgggag  720
ggaggagga  gtggaggat  tggccgtga  gctcacctc  ggagactct  aatctcatc  780
agagcctac  gaccatgtc  ttcaggaaa  gaagatggc  ctactgagc  tgctgtgct  840
tactctggt  tcagaagta  acatgaaca  tacatctga  cccaccctg  ctgccattt  900
tgaaatctg  cgtgaactt  ccctcctgg  gcctgagtt  atcctcaag  catctttgt  960
tgccaggca  cagctgaac  tccggaatg  ggccaataa  atcttggcc  ttgctgctt  1020
cttgccggc  tgtcgcccc  acctgcgac  atatttctg  gccattgtc  agctgcctt  1080
tgactggat  caggtggct  agctttacc  gagcctggc  gagggagat  agaataagc  1140
ggtgcccct  cccgcctgt  tccgtactg  catgacgga  aaatttgcc  agtttgacg  1200
gtaccagct  gctaagtac  accctcgga  gcaccgggc  aagagacac  cccgccggc  1260
accccgctc  ccagggatg  agcctccat  ttctcacag  tgttttcca  ggtacatag  1320
gtttctcag  gaagagcag  gaaagtttg  gaaggccgg  gatacagtg  cagagaaaa  1380
gaatcctcc  aggttcacc  tgaagaagc  ggttcagcg  ctgcacatc  acaagcctg  1440
ccagcacgt  caagccctg  tgggttaca  atacccctc  aacctacag  tcttttctc  1500
aagtcgcct  cctgggcct  gggattcta  cagagctgg  aagaggatg  agctgtcta  1560
gccagagac  tgggagcgg  agctgagcc  acgggggaa  aaagcgtcg  tctgggagg  1620
actcattga  aatgggaag  ttcccttca  ggccatgct  cggaacctg  gcaacctgc  1680
gcgggttgg  atcagttcc  gccaccatg  gctcattct  cagagactc  agcatggga  1740
gtcggtgat  cacagtcgg  agtttccat  cagatttct  aacgcccat  atgccattg  1800
tgccctcga  gctcaactc  gaaatcaag  attgccctt  ccttcgaat  taacactga  1860
gaggcggat  ctaactaga  atgaaaaga  ccgtcccag  cggaggttt  tttgccacc  1920
aagccgtca  cagcttcgt  tggcaatga  gatacctgt  ttgtatgag  agctcaaga  1980
ggagaagct  agagtacac  aggccagac  gtggaaata  gatggtgag  tgctgaaca  2040
gtaccgaca  gccctagag  cagctgtga  cctctctgt  aagcacagc  tgcccctgc  2100
gccaggccg  actgtcttg  tctatctga  agatgctaa  gcagacagg  tctgtccaa  2160
gagcaaccc  caagggccc  cgctgaact  tgcactgct  ttgattggg  tgatgatca  2220
gagggcgga  caggtggac  tcgtgctgt  tggaggtga  actctgaag  ctgcagtgc  2280
taaggcaga  gaaggcatc  tgaagactg  catcaagct  caggctcaa  tccaggagt  2340
tgatgaaaa  gatggatgg  ccctgaata  ttttgggaa  tacctgctg  ctctggctg  2400
ccaaagggt  cctgtggac  gggtcatcc  ccttggcca  agcatggat  atggaatga  2460
aaatgtggc  aaacagctt  actggcagc  tgtgaattc  aagtgcctc  ttgttggta  2520
cctcctaag  agggtacaa  acctgtcaa  agatttgaa  cccaatgat  tgacactct  2580
aggctgtac  gatgcgata  tgaagttca  tgcagagca  ggggcctcc  atcttctgg  2640
acatgtggg  caaatggac  aaatattca  gattccacc  cccccagga  agacagggg  2700
ccagtctct  cggccactg  aagaggaca  tccaagccc  ttggctcct  tttcccagc  2760
aggatggcg  agcatccgg  ttttcattt  atccacttt  cgagacatg  acggggagc  2820
ggacctgct  ctgaggtct  tgctgccag  actgcaggc  cgagcggcc  ctcaccgta  2880
cagccttca  ggaatcgac  tccgctggg  cgtcactga  gaggagacc  gtaggaaca  2940
acaactgga  gtgtgcctt  gggaggtgg  gaacgcaca  ctgtttgtg  ggattctgg  3000
ctcccgtta  ggatacatt  cccccagct  caaccttcc  gaccatcca  acttccact  3060
ggcccagca  tacccttca  ggcgctctg  gacagagat  gaggtgatg  agttcctga  3120
ccggaacca  cgtctgcag  cctctgccc  agctctcat  tacttccgg  attccagct  3180
cctcagctc  gtgccagat  cctggaaat  tgactttgt  tctgagtct  aagaggccg  3240
atgtcggat  tcagaactg  agagctacc  aagcagaca  aaagggata  cctgccgca  3300
atacccctg  gagtggggg  gtgtggcag  tggccggcc  tatgttggc  ggctggagg  3360
gtttgggca  ttggttctg  aggatgtat  gaatatgat  cagaagctc  acctgcagc  3420
tggggccct  ctggagcag  cagtgtcca  cccagacga  gacttggtc  aggccacct  3480
ccagcagct  cagaagcca  cgagtcctg  ccggccacg  cttcttcag  acacagtgc  3540
acagctgat  ctgccccac  gaaggctga  cctggtgac  gggcagtca  gacagggca  3600
gacagcctt  ctggcatct  ttgtgtcag  cctgcaggc  cctgatggg  ccaaggtgg  3660
accattagt  ttcttccac  tttctgggg  tcgtcctga  cagggtctt  ccctcactc  3720
gctcagacg  ctctgtacc  atctgcgtg  ccaactaaa  gagccaggt  ccctcccca  3780
cacctaccg  agcctggtg  gggagctgc  gcagaggct  ctgcccaag  ctgctgagt  3840
cctgcatcc  ggccagacc  aggtcctga  catcgatgg  gctgatagg  tagtggacc  3900
gaatgggca  ctgatttca  actggatcc  aaagaagct  ccccggtgt  tacacctgg  3960
gctgagtgt  tctagtgat  caggcctag  ggagaccct  gagcagagc  agggtgccc  4020
cgtgctggc  ttggggcct  tggaggcct  tgctcgggc  cggctggtg  gagaggagc  4080
ggccctgta  gggaagcgg  tggaggagt  accatttaa  aaccagatg  gactgctgc  4140
ggtgaagcg  gaatcaggc  ggccgctct  cctgcgctt  gtcaccgat  acctgaggc  4200
cttcacgct  tatgagcag  tgtctgaga  actccggac  ctgcctgcc  ctgtccccc  4260
gctgctgca  cacatcctg  gcacactgg  gaaggagca  gggcctgat  tccttcccc  4320
ggccttgac  gccctagaa  tcacacgga  tggtttgac  gtggaccag  tgcacggag  4380
gctgagtgt  tggcggaca  taccgaagg  gactaagag  tgggaagaa  cagtggctg  4440
tggtaacag  ggagacccc  accccatgg  cccgtttgc  tgcctcgtc  agagtctgc  4500
cagtttgct  ggggagggc  ctctggagc  ccctggtgc  cggctgtgc  tccctgatg  4560
gcccctgag  acagcagct  aacgttgct  tgggaagag  ccagggcta  aggacacgg  4620
acacatcct  attgcagct  agctctgga  gacatgtga  gctgatgcc  caggcacct  4680
ccgaagttg  cctcctgag  ctctgggag  cctgcctta  cacctgctc  agagcggga  4740
ccgtggact  ctttcgaag  tccttacca  cctccatgt  gtggctgca  acttggaat  4800
gggtctggt  tctcggctc  tggaggccc  tgccctcta  gcttcttca  tccccaaag  4860
ggaacaaaa  ctccccgag  ctgacgttg  agtgtttcg  accttcctg  ggcagcagg  4920
ttcaatcct  agccagtac  cccggctcc  gccccagca  gcagccaac  agcccctgg  4980
ctcacctct  tgccaccaa  cctcgctgc  ctcccggag  tggcacctc  aacacacac  5040
acgatggct  aataaaccc  ggaccatga  aaatcagca  agctccagc  tgtctctgg  5100
agtttcctc  tcccctact  ctgtggcct  ctccaccaa  gggcaaaga  cagctgtgg  5160
cactgccaa  gggacagtt  acctgttgg  cctgagaac  tggcaggag  agaagtctg  5220
ggtgagtgg  tgtgatgga  tctctgctt  tttgttcct  tccgatgat  cactctttc  5280
tactgcctt  gacgggctc  tggagctct  ggacctgca  catggttgt  gggtgctgc  5340
gactaaggc  caccagtac  aaatcactg  ctgctgcct  agcccagac  gccggctgc  5400
agccaccgt  tgcttggga  gatgcctaa  gctgtggga  acagtccgt  ggcagctgg  5460
cttccagca  acctacccc  agtccctga  ctgtgttgc  ttccaccca  aggggcagg  5520
aatagccac  ggcagctgg  ctggcagca  cagcttctt  caggtggat  ggctcaaag  5580
caccaagga  ctgggggca  ccggagcct  tatccgtac  ttggccttc  atgtgcctg  5640
gggggttgt  gctgtgggc  ggctggaca  tatggtgga  ctgtgggcc  ggcgagaag  5700
ggcacggct  gctgccttc  ctgcccacc  tggctttgt  gctgctgcg  ttttcctgc  5760
tgcgggttg  cagttactg  cggctggag  ggatggcaa  gttcaggtg  ggtcagggt  5820
tctgggtcg  ccccgtggg  acctgggtt  cctttctct  tctcctgcc  tctctgtgg  5880
actcagccc  gatggtgat  gggtggctg  tggatatcg  gcggatggc  ttaggatct  5940
caaaatctc  tcaggttcc  agggggctc  gggtcaggc  ctggatgtg  cagtgtccg  6000
cctggcctg  ctaagcccc  aggtattgg  gagtggtgc  gaagatggg  ccttgcagg  6060
ctgggcact  aaggaatgc  cccttcagt  cctctggct  ctgtccaga  tccagaagc  6120
tgtgctagg  ctggccact  cccaggagc  cttggcttc  gcctcagag  atttcacag  6180
gcagctgtg  ccaaggcag  tgctgacgc  gccacacaa  gcagaagac  ttccctgtg  6240
cactgagct  cggggacat  agggccctg  gagctgctg  agtttcagc  ctgatggag  6300
cagcctggc  accgggggc  gggatcgga  tctcctctg  tgggacgtg  ggacaccca  6360
aacccctgt  ttgatccac  ccttccctg  ctgtcaccg  gactgggtc  ctggctgtg  6420
ctggaccaa  gataaccta  tgatatcct  ctccagtga  ggctctgtg  ggctctggg  6480
cccagagtc  ggacagcgg  ttggtcagt  cctgggtca  cagagtgct  tgagcgctg  6540
ggcagctgt  gaggagcac  tggtgtctg  gagccggga  gggaccttg  aagtgtggg  6600
ccatcaagg  gtggagctg  ccagcatcc  tgctcactc  ggacccatt  gccactgtg  6660
agctgccat  gagccccgt  cagctggac  gcctgggtc  gagcttctg  tggtaaccg  6720
cgggctaga  ggggccaca  ggttatggc  tccactctt  gtgtgccaa  cccacaccc  6780
cctgggaca  agcggccca  tccgtgctg  tgctgtttc  gaaacctca  gcctcatgc  6840
gaccgcctc  gaggatggt  ctgtacggc  ctggcaggt  cctaaggaa  cagatgaca  6900
atgtatacc  aggagttct  cagccgtca  tgctgtggc  tgggcacca  atggttcca  6960
ggcagtatc  ggaaatcaa  ctggggaac  aatcttgtg  caggaagct  aggctgtgg  7020
cacagcaca  gctccaggc  acattggtg  tctgatctg  tcctcggca  acacctttt  7080
tgtcctcag  gctgatgag  aaatcagcg  gtggcaagt  aaactgcgg  agggttcgg  7140
acccggaaa  ttgagtctt  acctgaacc  aattctaca  gaggactta  gggtgctga  7200
aagtctgga  tgggctcct  atggtcact  tctcatctt  gccaaagca  atttgaagt  7260
actttgcat  aagccaggg  atgctccat  tgaaatctg  agcagctat  cagaaaatc  7320
tatgatatt  tccacccac  aggagtatg  catatttgt  ctgcagccc  aggatcctg  7380
agttctttc  ttcttgagg  aaaaggaat  aggagagtt  gaagagagg  tgaactttg  7440
tataaactt  gagaatcct  gtaggaccc  aatatcgat  actcaagcc  aacctgaat  7500
tgagtcctc  tttttgtgt  ccagctctg  tgggatcct  tggaacctg  ccaaatgca  7560
cccagaagg  gaatggacc  caggtaaca  gtggcagaa  aaagcaaac  ctccagaaa  7620
ccaaactcc  gggacagac  catctacct  cagggaatc  gatgccagc  tggatagtg  7680
tgccagcat  gatagtgag  caacaccac  tctaaagac  cggcagcgt  gaaagattc  7740
ctcgggctc  gtcacagcc  tccatgtgc  acctgagtt  ctggtgaca  cttcgaagg  7800
cagagatgt  aagctatgg  agagaccca  tatgcagct  ctgggcctg  tccgatgcg  7860
agggtcagt  agctgcctg  aaccttggc  gggcgctaa  tccaccctg  agcttgccg  7920
gggagacgt  cagggcaat  tgtactttc  gaattggga  tgaagatgt  ccactcggg  7980
ataatgata  cccttgtgc  agagatgca  agcctgaag  cactggtag  ttttaataa  8040
tataaaatt  ataatttct  gataattat  aaaatgaag  gtcaaaaaa  ctcaagtgt  8100
ggcctgcct  tgttctcat  tggatttag  acaggagga  attctatgt  tatgtatat  8160
tacattcta  tgtgtgtct  ttcttattc  acattaatc  ttactagaa  cacaagaaa  8220
tgaatgaaa  ctttagtag  tactctttt  aaactaggt  ytagaattc  tgcatcact  8280
gcgggccct  ggaccctag  atgccattc  tgccaggag  aggaatgag  gtgatgttg  8340
ccaacattc  atttgaaca  agcatggaa  acctttcag  tcatcggga  agaatgagg  8400
agggagaat  agtcagtca  gcatcaggg  atttagaaa  agctatgtt  ctgtcacag  8460
gacagccct  ttctcagaa  tacccagag  aggccgggc  tggtggctc  cgcttgtaa  8520
cccagcact  tgggaggcc  aggtgggca  atcacgagg  caggagatc  agaccatcc  8580
ggctaacat  gtgaaaccc  gtctctact  aaaaataca  aaagttaac  aggcatgta  8640
cggccgctc  agaggatcc  agctt  8665



<210> 9056
<211> 2627
<212> PRT
<213> Homo sapiens
<308> XP_007488
<400> 9056

Met Glu Lys Leu His Gly His Val Ser Ala His Pro Asp Ile Leu Ser 
  1               5                  10                  15
Leu Glu Asn Arg Cys Leu Ala Met Leu Pro Asp Leu Gln Pro Leu Glu 
             20                  25                  30
Lys Leu His Gln His Val Ser Thr His Ser Asp Ile Leu Ser Leu Lys 
         35                  40                  45
Asn Gln Cys Leu Ala Thr Leu Pro Asp Leu Lys Thr Met Glu Lys Pro 
     50                  55                  60
His Gly Tyr Val Ser Ala His Pro Asp Ile Leu Ser Leu Glu Asn Gln 
 65                  70                  75                  80
Cys Leu Ala Thr Leu Ser Asp Leu Lys Thr Met Glu Lys Pro His Gly 
                 85                  90                  95
His Val Ser Ala His Pro Asp Ile Leu Ser Leu Glu Asn Arg Cys Leu 
             100                105                110
Ala Thr Leu Ser Ser Leu Lys Ser Thr Val Ser Ala Ser Pro Leu Phe 
         115                120                125
Gln Ser Leu Gln Ile Ser His Met Thr Gln Ala Asp Leu Tyr Arg Val 
     130                135                140
Asn Asn Ser Asn Cys Leu Leu Ser Glu Pro Pro Ser Trp Arg Ala Gln 
 145                150                155                160
His Phe Ser Lys Gly Leu Asp Leu Ser Thr Cys Pro Ile Ala Leu Lys 
                 165                170                175
Ser Ile Ser Ala Thr Glu Thr Ala Gln Glu Ala Thr Leu Gly Arg Trp 
             180                185                190
Phe Asp Ser Glu Glu Lys Lys Gly Ala Glu Thr Gln Met Pro Ser Tyr 
         195                200                205
Ser Leu Ser Leu Gly Glu Glu Glu Glu Val Glu Asp Leu Ala Val Lys 
     210                215                220
Leu Thr Ser Gly Asp Ser Glu Ser His Pro Glu Pro Thr Asp His Val 
 225                230                235                240
Leu Gln Glu Lys Lys Met Ala Leu Leu Ser Leu Leu Cys Ser Thr Leu 
                 245                250                255
Val Ser Glu Val Asn Met Asn Asn Thr Ser Asp Pro Thr Leu Ala Ala 
             260                265                270
Ile Phe Glu Ile Cys Arg Glu Leu Ala Leu Leu Glu Pro Glu Phe Ile 
         275                280                285
Leu Lys Ala Ser Leu Tyr Ala Arg Gln Gln Leu Asn Val Arg Asn Val 
     290                295                300
Ala Asn Asn Ile Leu Ala Ile Ala Ala Phe Leu Pro Ala Cys Arg Pro 
 305                310                315                320
His Leu Arg Arg Tyr Phe Cys Ala Ile Val Gln Leu Pro Ser Asp Trp 
                 325                330                335
Ile Gln Val Ala Glu Leu Tyr Gln Ser Leu Ala Glu Gly Asp Lys Asn 
             340                345                350
Lys Leu Val Pro Leu Pro Ala Cys Leu Arg Thr Ala Met Thr Asp Lys 
         355                360                365
Phe Ala Gln Phe Asp Glu Tyr Gln Leu Ala Lys Tyr Asn Pro Arg Lys 
     370                375                380
His Arg Ala Lys Arg His Pro Arg Arg Pro Pro Arg Ser Pro Gly Met 
 385                390                395                400
Glu Pro Pro Phe Ser His Arg Cys Phe Pro Arg Tyr Ile Gly Phe Leu 
                 405                410                415
Arg Glu Glu Gln Arg Lys Phe Glu Lys Ala Gly Asp Thr Val Ser Glu 
             420                425                430
Lys Lys Asn Pro Pro Arg Phe Thr Leu Lys Lys Leu Val Gln Arg Leu 
         435                440                445
His Ile His Lys Pro Ala Gln His Val Gln Ala Leu Leu Gly Tyr Arg 
     450                455                460
Tyr Pro Ser Asn Leu Gln Leu Phe Ser Arg Ser Arg Leu Pro Gly Pro 
 465                470                475                480
Trp Asp Ser Ser Arg Ala Gly Lys Arg Met Lys Leu Ser Arg Pro Glu 
                 485                490                495
Thr Trp Glu Arg Glu Leu Ser Leu Arg Gly Asn Lys Ala Ser Val Trp 
             500                505                510
Glu Glu Leu Ile Glu Asn Gly Lys Leu Pro Phe Met Ala Met Leu Arg 
         515                520                525
Asn Leu Cys Asn Leu Leu Arg Val Gly Ile Ser Ser Arg His His Glu 
     530                535                540
Leu Ile Leu Gln Arg Leu Gln His Ala Lys Ser Val Ile His Ser Arg 
 545                550                555                560
Gln Phe Pro Phe Arg Phe Leu Asn Ala His Asp Ala Ile Asp Ala Leu 
                 565                570                575
Glu Ala Gln Leu Arg Asn Gln Ala Leu Pro Phe Pro Ser Asn Ile Thr 
             580                585                590
Leu Met Arg Arg Ile Leu Thr Arg Asn Glu Lys Asn Arg Pro Arg Arg 
         595                600                605
Arg Phe Leu Cys His Leu Ser Arg Gln Gln Leu Arg Met Ala Met Arg 
     610                615                620
Ile Pro Val Leu Tyr Glu Gln Leu Lys Arg Glu Lys Leu Arg Val His 
 625                630                635                640
Lys Ala Arg Gln Trp Lys Tyr Asp Gly Glu Met Leu Asn Arg Tyr Arg 
                 645                650                655
Gln Ala Leu Glu Thr Ala Val Asn Leu Ser Val Lys His Ser Leu Pro 
             660                665                670
Leu Leu Pro Gly Arg Thr Val Leu Val Tyr Leu Thr Asp Ala Asn Ala 
         675                680                685
Asp Arg Leu Cys Pro Lys Ser Asn Pro Gln Gly Pro Pro Leu Asn Tyr 
     690                695                700
Ala Leu Leu Leu Ile Gly Met Met Ile Thr Arg Ala Glu Gln Val Asp 
 705                710                715                720
Val Val Leu Cys Gly Gly Asp Thr Leu Lys Thr Ala Val Leu Lys Ala 
                 725                730                735
Glu Glu Gly Ile Leu Lys Thr Ala Ile Lys Leu Gln Ala Gln Val Gln 
             740                745                750
Glu Phe Asp Glu Asn Asp Gly Trp Ser Leu Asn Thr Phe Gly Lys Tyr 
         755                760                765
Leu Leu Ser Leu Ala Gly Gln Arg Val Pro Val Asp Arg Val Ile Leu 
     770                775                780
Leu Gly Gln Ser Met Asp Asp Gly Met Ile Asn Val Ala Lys Gln Leu 
 785                790                795                800
Tyr Trp Gln Arg Val Asn Ser Lys Cys Leu Phe Val Gly Ile Leu Leu 
                 805                810                815
Arg Arg Val Gln Tyr Leu Ser Thr Asp Leu Asn Pro Asn Asp Val Thr 
             820                825                830
Leu Ser Gly Cys Thr Asp Ala Ile Leu Lys Phe Ile Ala Glu His Gly 
         835                840                845
Ala Ser His Leu Leu Glu His Val Gly Gln Met Asp Lys Ile Phe Lys 
     850                855                860
Ile Pro Pro Pro Pro Gly Lys Thr Gly Val Gln Ser Leu Arg Pro Leu 
 865                870                875                880
Glu Glu Asp Thr Pro Ser Pro Leu Ala Pro Val Ser Gln Gln Gly Trp 
                 885                890                895
Arg Ser Ile Arg Leu Phe Ile Ser Ser Thr Phe Arg Asp Met His Gly 
             900                905                910
Glu Arg Asp Leu Leu Leu Arg Ser Val Leu Pro Ala Leu Gln Ala Arg 
         915                920                925
Ala Ala Pro His Arg Ile Ser Leu His Gly Ile Asp Leu Arg Trp Gly 
     930                935                940
Val Thr Glu Glu Glu Thr Arg Arg Asn Arg Gln Leu Glu Val Cys Leu 
 945                950                955                960
Gly Glu Val Glu Asn Ala Gln Leu Phe Val Gly Ile Leu Gly Ser Arg 
                 965                970                975
Tyr Gly Tyr Ile Pro Pro Ser Tyr Asn Leu Pro Asp His Pro His Phe 
             980                985                990
His Trp Ala Gln Gln Tyr Pro Ser Gly Arg Ser Val Thr Glu Met Glu 
         995                1000                1005
Val Met Gln Phe Leu Asn Arg Asn Gln Arg Leu Gln Pro Ser Ala Gln 
     1010                1015                1020
Ala Leu Ile Tyr Phe Arg Asp Ser Ser Phe Leu Ser Ser Val Pro Asp 
 1025                1030                1035                1040
Ala Trp Lys Ser Asp Phe Val Ser Glu Ser Glu Glu Ala Ala Arg Arg 
                 1045                1050                1055
Ile Ser Glu Leu Lys Ser Tyr Leu Ser Arg Gln Lys Gly Ile Thr Cys 
             1060                1065                1070
Arg Arg Tyr Pro Cys Glu Trp Gly Gly Val Ala Ala Gly Arg Pro Tyr 
         1075                1080                1085
Val Gly Gly Leu Glu Glu Phe Gly Gln Leu Val Leu Gln Asp Val Trp 
     1090                1095                1100
Asn Met Ile Gln Lys Leu Tyr Leu Gln Pro Gly Ala Leu Leu Glu Gln 
 1105                1110                1115                1120
Pro Val Ser Ile Pro Asp Asp Asp Leu Val Gln Ala Thr Phe Gln Gln 
                 1125                1130                1135
Leu Gln Lys Pro Pro Ser Pro Ala Arg Pro Arg Leu Leu Gln Asp Thr 
             1140                1145                1150
Val Gln Arg Leu Met Leu Pro His Gly Arg Leu Ser Leu Val Thr Gly 
         1155                1160                1165
Gln Ser Gly Gln Gly Lys Thr Ala Phe Leu Ala Ser Leu Val Ser Ala 
     1170                1175                1180
Leu Gln Ala Pro Asp Gly Ala Lys Val Ala Ser Leu Val Phe Phe His 
 1185                1190                1195                1200
Phe Ser Gly Ala Arg Pro Asp Gln Gly Leu Ala Leu Thr Leu Leu Arg 
                 1205                1210                1215
Arg Leu Cys Thr Tyr Leu Arg Gly Gln Leu Lys Glu Pro Gly Ala Leu 
             1220                1225                1230
Pro Ser Thr Tyr Arg Ser Leu Val Trp Glu Leu Gln Gln Arg Leu Leu 
         1235                1240                1245
Pro Lys Ser Ala Glu Ser Leu His Pro Gly Gln Thr Gln Val Leu Ile 
     1250                1255                1260
Ile Asp Gly Ala Asp Arg Leu Val Asp Gln Asn Gly Gln Leu Ile Ser 
 1265                1270                1275                1280
Asp Trp Ile Pro Lys Lys Leu Pro Arg Cys Val His Leu Val Leu Ser 
                 1285                1290                1295
Val Ser Ser Asp Ala Gly Leu Gly Glu Thr Leu Glu Gln Ser Gln Gly 
             1300                1305                1310
Ala His Val Leu Ala Leu Gly Pro Leu Glu Ala Ser Ala Arg Ala Arg 
         1315                1320                1325
Leu Val Arg Glu Glu Leu Ala Leu Tyr Gly Lys Arg Leu Glu Glu Ser 
     1330                1335                1340
Pro Phe Asn Asn Gln Met Arg Leu Leu Leu Val Lys Arg Glu Ser Gly 
 1345                1350                1355                1360
Arg Pro Leu Tyr Leu Arg Leu Val Thr Asp His Leu Arg Leu Phe Thr 
                 1365                1370                1375
Leu Tyr Glu Gln Val Ser Glu Arg Leu Arg Thr Leu Pro Ala Thr Val 
             1380                1385                1390
Pro Leu Leu Leu Gln His Ile Leu Ser Thr Leu Glu Lys Glu His Gly 
         1395                1400                1405
Pro Asp Val Leu Pro Gln Ala Leu Thr Ala Leu Glu Val Thr Arg Ser 
     1410                1415                1420
Gly Leu Thr Val Asp Gln Leu His Gly Val Leu Ser Val Trp Arg Thr 
 1425                1430                1435                1440
Leu Pro Lys Gly Thr Lys Ser Trp Glu Glu Ala Val Ala Ala Gly Asn 
                 1445                1450                1455
Ser Gly Asp Pro Tyr Pro Met Gly Pro Phe Ala Cys Leu Val Gln Ser 
             1460                1465                1470
Leu Arg Ser Leu Leu Gly Glu Gly Pro Leu Glu Arg Pro Gly Ala Arg 
         1475                1480                1485
Leu Cys Leu Pro Asp Gly Pro Leu Arg Thr Ala Ala Lys Arg Cys Tyr 
     1490                1495                1500
Gly Lys Arg Pro Gly Leu Glu Asp Thr Ala His Ile Leu Ile Ala Ala 
 1505                1510                1515                1520
Gln Leu Trp Lys Thr Cys Asp Ala Asp Ala Ser Gly Thr Phe Arg Ser 
                 1525                1530                1535
Cys Pro Pro Glu Ala Leu Gly Asp Leu Pro Tyr His Leu Leu Gln Ser 
             1540                1545                1550
Gly Asn Arg Gly Leu Leu Ser Lys Phe Leu Thr Asn Leu His Val Val 
         1555                1560                1565
Ala Ala His Leu Glu Leu Gly Leu Val Ser Arg Leu Leu Glu Ala His 
     1570                1575                1580
Ala Leu Tyr Ala Ser Ser Val Pro Lys Glu Glu Gln Lys Leu Pro Glu 
 1585                1590                1595                1600
Ala Asp Val Ala Val Phe Arg Thr Phe Leu Arg Gln Gln Ala Ser Ile 
                 1605                1610                1615
Leu Ser Gln Tyr Pro Arg Leu Leu Pro Gln Gln Ala Ala Asn Gln Pro 
             1620                1625                1630
Leu Asp Ser Pro Leu Cys His Gln Ala Ser Leu Leu Ser Arg Arg Trp 
         1635                1640                1645
His Leu Gln His Thr Leu Arg Trp Leu Asn Lys Pro Arg Thr Met Lys 
     1650                1655                1660
Asn Gln Gln Ser Ser Ser Leu Ser Leu Ala Val Ser Ser Ser Pro Thr 
 1665                1670                1675                1680
Ala Val Ala Phe Ser Thr Asn Gly Gln Arg Ala Ala Val Gly Thr Ala 
                 1685                1690                1695
Asn Gly Thr Val Tyr Leu Leu Asp Leu Arg Thr Trp Gln Glu Glu Lys 
             1700                1705                1710
Ser Val Val Ser Gly Cys Asp Gly Ile Ser Ala Cys Leu Phe Leu Ser 
         1715                1720                1725
Asp Asp Thr Leu Phe Leu Thr Ala Phe Asp Gly Leu Leu Glu Leu Trp 
     1730                1735                1740
Asp Leu Gln His Gly Cys Arg Val Leu Gln Thr Lys Ala His Gln Tyr 
 1745                1750                1755                1760
Gln Ile Thr Gly Cys Cys Leu Ser Pro Asp Cys Arg Leu Leu Ala Thr 
                 1765                1770                1775
Val Cys Leu Gly Gly Cys Leu Lys Leu Trp Asp Thr Val Arg Gly Gln 
             1780                1785                1790
Leu Ala Phe Gln His Thr Tyr Pro Lys Ser Leu Asn Cys Val Ala Phe 
         1795                1800                1805
His Pro Glu Gly Gln Val Ile Ala Thr Gly Ser Trp Ala Gly Ser Ile 
     1810                1815                1820
Ser Phe Phe Gln Val Asp Gly Leu Lys Val Thr Lys Asp Leu Gly Ala 
 1825                1830                1835                1840
Pro Gly Ala Ser Ile Arg Thr Leu Ala Phe Asn Val Pro Gly Gly Val 
                 1845                1850                1855
Val Ala Val Gly Arg Leu Asp Ser Met Val Glu Leu Trp Ala Trp Arg 
             1860                1865                1870
Glu Gly Ala Arg Leu Ala Ala Phe Pro Ala His His Gly Phe Val Ala 
         1875                1880                1885
Ala Ala Leu Phe Leu His Ala Gly Cys Gln Leu Leu Thr Ala Gly Glu 
     1890                1895                1900
Asp Gly Lys Val Gln Val Trp Ser Gly Ser Leu Gly Arg Pro Arg Gly 
 1905                1910                1915                1920
His Leu Gly Ser Leu Ser Leu Ser Pro Ala Leu Ser Val Ala Leu Ser 
                 1925                1930                1935
Pro Asp Gly Asp Arg Val Ala Val Gly Tyr Arg Ala Asp Gly Ile Arg 
             1940                1945                1950
Ile Tyr Lys Ile Ser Ser Gly Ser Gln Gly Ala Gln Gly Gln Ala Leu 
         1955                1960                1965
Asp Val Ala Val Ser Ala Leu Ala Trp Leu Ser Pro Lys Val Leu Val 
     1970                1975                1980
Ser Gly Ala Glu Asp Gly Ser Leu Gln Gly Trp Ala Leu Lys Glu Cys 
 1985                1990                1995                2000
Ser Leu Gln Ser Leu Trp Leu Leu Ser Arg Phe Gln Lys Pro Val Leu 
                 2005                2010                2015
Gly Leu Ala Thr Ser Gln Glu Leu Leu Ala Ser Ala Ser Glu Asp Phe 
             2020                2025                2030
Thr Val Gln Leu Trp Pro Arg Gln Leu Leu Thr Arg Pro His Lys Ala 
         2035                2040                2045
Glu Asp Phe Pro Cys Gly Thr Glu Leu Arg Gly His Glu Gly Pro Val 
     2050                2055                2060
Ser Cys Cys Ser Phe Ser Thr Asp Gly Gly Ser Leu Ala Thr Gly Gly 
 2065                2070                2075                2080
Arg Asp Arg Ser Leu Leu Cys Trp Asp Val Arg Thr Pro Lys Thr Pro 
                 2085                2090                2095
Val Leu Ile His Ser Phe Pro Ala Cys His Arg Asp Trp Val Thr Gly 
             2100                2105                2110
Cys Ala Trp Thr Lys Asp Asn Leu Leu Ile Ser Cys Ser Ser Asp Gly 
         2115                2120                2125
Ser Val Gly Leu Trp Asp Pro Glu Ser Gly Gln Arg Leu Gly Gln Phe 
     2130                2135                2140
Leu Gly His Gln Ser Ala Val Ser Ala Val Ala Ala Val Glu Glu His 
 2145                2150                2155                2160
Val Val Ser Val Ser Arg Asp Gly Thr Leu Lys Val Trp Asp His Gln 
                 2165                2170                2175
Gly Val Glu Leu Thr Ser Ile Pro Ala His Ser Gly Pro Ile Ser His 
             2180                2185                2190
Cys Ala Ala Ala Met Glu Pro Arg Ala Ala Gly Gln Pro Gly Ser Glu 
         2195                2200                2205
Leu Leu Val Val Thr Val Gly Leu Asp Gly Ala Thr Arg Leu Trp His 
     2210                2215                2220
Pro Leu Leu Val Cys Gln Thr His Thr Leu Leu Gly His Ser Gly Pro 
 2225                2230                2235                2240
Val Arg Ala Ala Ala Val Ser Glu Thr Ser Gly Leu Met Leu Thr Ala 
                 2245                2250                2255
Ser Glu Asp Gly Ser Val Arg Leu Trp Gln Val Pro Lys Glu Ala Asp 
             2260                2265                2270
Asp Thr Cys Ile Pro Arg Ser Ser Ala Ala Val Thr Ala Val Ala Trp 
         2275                2280                2285
Ala Pro Asp Gly Ser Met Ala Val Ser Gly Asn Gln Ala Gly Glu Leu 
     2290                2295                2300
Ile Leu Trp Gln Glu Ala Lys Ala Val Ala Thr Ala Gln Ala Pro Gly 
 2305                2310                2315                2320
His Ile Gly Ala Leu Ile Trp Ser Ser Ala His Thr Phe Phe Val Leu 
                 2325                2330                2335
Ser Ala Asp Glu Lys Ile Ser Glu Trp Gln Val Lys Leu Arg Lys Gly 
             2340                2345                2350
Ser Ala Pro Gly Asn Leu Ser Leu His Leu Asn Arg Ile Leu Gln Glu 
         2355                2360                2365
Asp Leu Gly Val Leu Thr Ser Leu Asp Trp Ala Pro Asp Gly His Phe 
     2370                2375                2380
Leu Ile Leu Ala Lys Ala Asp Leu Lys Leu Leu Cys Met Lys Pro Gly 
 2385                2390                2395                2400
Asp Ala Pro Ser Glu Ile Trp Ser Ser Tyr Thr Glu Asn Pro Met Ile 
                 2405                2410                2415
Leu Ser Thr His Lys Glu Tyr Gly Ile Phe Val Leu Gln Pro Lys Asp 
             2420                2425                2430
Pro Gly Val Leu Ser Phe Leu Arg Gln Lys Glu Ser Gly Glu Phe Glu 
         2435                2440                2445
Glu Arg Leu Asn Phe Asp Ile Asn Leu Glu Asn Pro Ser Arg Thr Leu 
     2450                2455                2460
Ile Ser Ile Thr Gln Ala Lys Pro Glu Ser Glu Ser Ser Phe Leu Cys 
 2465                2470                2475                2480
Ala Ser Ser Asp Gly Ile Leu Trp Asn Leu Ala Lys Cys Ser Pro Glu 
                 2485                2490                2495
Gly Glu Trp Thr Thr Gly Asn Met Trp Gln Lys Lys Ala Asn Thr Pro 
             2500                2505                2510
Glu Thr Gln Thr Pro Gly Thr Asp Pro Ser Thr Cys Arg Glu Ser Asp 
         2515                2520                2525
Ala Ser Met Asp Ser Asp Ala Ser Met Asp Ser Glu Pro Thr Pro His 
     2530                2535                2540
Leu Lys Thr Arg Gln Arg Arg Lys Ile His Ser Gly Ser Val Thr Ala 
 2545                2550                2555                2560
Leu His Val Leu Pro Glu Leu Leu Val Thr Ala Ser Lys Asp Arg Asp 
                 2565                2570                2575
Val Lys Leu Trp Glu Arg Pro Ser Met Gln Leu Leu Gly Leu Phe Arg 
             2580                2585                2590
Cys Glu Gly Ser Val Ser Cys Leu Glu Pro Trp Leu Gly Ala Asn Ser 
         2595                2600                2605
Thr Leu Gln Leu Ala Val Gly Asp Val Gln Gly Asn Val Tyr Phe Leu 
     2610                2615                2620
Asn Trp Glu 
 2625



<210> 9057
<211> 3098
<212> DNA
<213> Rattus norvegicus
<308> U89529
<400> 9057

aagttccca  tccagactt  tgcgagaac  cgtgaggaa  cagcgagaa  cgggggttt  60
caagccaga  aaggatgcg  actccggga  caggaacag  ctctgtggc  tcattgggg  120
tgctttggc  tctgggact  ccgtggacc  ggagcgcgg  ggcggcgtt  ggtgtgtac  180
tgggtagcg  tggctggcg  tttctgcgt  tcgtctgca  gacggcgag  cgagacctc  240
ttggcctct  tgttctgat  cgcgtgcgg  tagagctac  acgacaccg  cgagcagga  300
acacgatcc  acgcatctt  caggccgtg  cccagcgac  gccggagcg  ctggcgctg  360
tagatgcga  tagcggtat  tgctggacc  tcgcacagc  agacaccta  tccaatgct  420
tggccaatc  gttcctcca  ctgggcttt  cgccaggcg  tgtggtggc  gtgttcctg  480
aaggccggc  cgagttcgt  ggactgtgg  tgggcctgg  caaggccgg  gtagtggct  540
cgcttctca  tgtcaacct  aggcgggag  cccttgcct  ctgcttggg  acatcagct  600
ccaaggccc  catttatgg  ggggagatg  cagcggcgg  ggcggaggt  agtgagcag  660
tggggaaga  cctgctcaa  ttctgctct  gagatctgg  gcctgagag  gtcctgcct  720
acacgcagc  tctggaccc  atgcttgct  aggcgccca  cacacccct  gcacaggcc  780
caggcaagg  catggatga  cggctattt  acatctata  ttctgggac  accggactt  840
ctaaggcgg  cattgtggt  cacagcagg  actaccgca  cgcagcctt  ggccaccat  900
cctacagca  gcgggccaa  gatgtgctc  atgactgcc  acctctcta  cactcagca  960
ggaacatca  gggcgtggg  cagtgtatc  tctacgggt  aacggtggt  ctgcgcaag  1020
agttctccg  cagccgctt  tgggacgac  gtgtcaaat  taattgcac  gtagtgcag  1080
acatcggtg  aatatgccg  tacctgcta  ggcagccgg  tcgcgatgt  gagcggcgg  1140
accgcgtgc  cctggccgt  ggtaacgga  tgcggccag  catctggga  gagttcacg  1200
agggtttcg  tgtgcgaca  attggcgag  tctacggcg  caccgaatg  aactgcagc  1260
ttgccaaca  ggacggcaa  gtcggctcc  gcggcttca  cagccgtat  ctcacgcat  1320
tgtacccca  ccgtctggt  aaggtcaac  aggacacga  ggagccact  agggactcc  1380
aaggcctct  catcccgtg  cagcccggg  aacctgggc  tctcgtggg  cagatcaac  1440
agcaagacc  tctgcggcg  ttcgatggc  atgttagtg  cagcgccac  aacaagaag  1500
ttgcccaca  cgtgttccg  aagggggac  gcgcctacc  ttcaggtga  gtgctagtg  1560
tggacgagc  ggggtacat  tacttccgt  accgcagcg  ggatacctt  cgatggcgc  1620
gcgagaacg  atccaccac  gaggtggaa  ccgtgctga  ccgcctgtt  ggccagacg  1680
acgtggctg  gtatggagt  gctgtgcca  gagtggagg  gaaaagcgg  atggcggcc  1740
ttgcagacc  ccacaacca  ctggaccct  actcaatgt  ccaggaatt  cagaaggtt  1800
ttgcatcct  tgcccagcc  atcttcctg  gtcttctgc  ccaagtgga  acaacaggc  1860
ccttcaaga  ccagaagac  cgactacag  gtgaaggct  tgacccccg  cagacctca  1920
accggctct  ctttctaga  ctgaaacag  gacgctacc  acccctgga  gagagagtc  1980
atgcccgca  ctgcgcagg  gacttctca  tctgagcct  gtgagtggg  tggccctgg  2040
cttgtgaga  cagggagcc  gacacccct  ttcaggtgt  tctcctgcc  ggccacgtg  2100
ccagcagca  ctgtgggtg  aggaaactg  aacctgagt  gccgggtgt  cctttccta  2160
aacccacca  gcacacatc  agcctctgc  ttggtcttt  tctccatct  tttcctccg  2220
gcccagcag  agccccaca  acacattgg  tgctgtgtc  tgcagtggg  ccggtgtct  2280
ggggtccat  ctgcaggct  tgacccgca  tggtgccca  ctcccttcc  cattgtgcc  2340
taggttcct  cactgtgcg  cggtgaagc  agtggggac  cacatagct  ttgtccctg  2400
tgagggttg  tagcaaatg  accctcatg  cagctggga  acacatgca  tctcccact  2460
acccccaat  aactgaaga  actgttttg  attattgtt  tgagatagg  tctcactgt  2520
gaggccaag  tggcctcag  ctcaccact  tactgcctc  gggcaccag  ctgcagttt  2580
atgacatgt  tgcactatt  ttctaaggg  cttctgagt  cctgctttc  cctcatgtc  2640
taaaacctt  cagaactga  tctgatcac  tggatgtag  tagtgttgg  cctgcccac  2700
tgtgtcaat  caggggtcc  caggcatca  ctctggagg  cctaacctt  gcaaagctt  2760
gatgtcctc  catcacagc  ggagaccca  gaaggttgc  gtggtgtct  ttgggcacc  2820
ctggcggca  ccgtggaca  gcttccctg  tgtgatagc  caaactgtt  cctatgaca  2880
ttgaggtct  cccttctgg  tgccatggt  cccattgag  tctttggtg  ctcacctca  2940
ccaccaagc  aggcctctg  cttccttca  ctctaaggg  atgaagggt  tggacagag  3000
agccacagg  tgcccacag  cacccacat  caagtgtta  ttccttgtt  gttttaaaa  3060
aataaacat  ctgagcctt  aaaaaaaaa  aaaaaaaa  3098



<210> 9058
<211> 646
<212> PRT
<213> Rattus norvegicus
<308> P97849
<400> 9058

Met Arg Thr Pro Gly Ala Gly Thr Ala Ser Val Ala Ser Leu Gly Leu 
  1               5                  10                  15
Leu Trp Leu Leu Gly Leu Pro Trp Thr Trp Ser Ala Ala Ala Ala Phe 
             20                  25                  30
Gly Val Tyr Val Gly Ser Gly Gly Trp Arg Phe Leu Arg Ile Val Cys 
         35                  40                  45
Lys Thr Ala Arg Arg Asp Leu Phe Gly Leu Ser Val Leu Ile Arg Val 
     50                  55                  60
Arg Leu Glu Leu Arg Arg His Arg Arg Ala Gly Asp Thr Ile Pro Arg 
 65                  70                  75                  80
Ile Phe Gln Ala Val Ala Gln Arg Gln Pro Glu Arg Leu Ala Leu Val 
                 85                  90                  95
Asp Ala Ser Ser Gly Ile Cys Trp Thr Phe Ala Gln Leu Asp Thr Tyr 
             100                105                110
Ser Asn Ala Val Ala Asn Leu Phe Leu Gln Leu Gly Phe Ala Pro Gly 
         115                120                125
Asp Val Val Ala Val Phe Leu Glu Gly Arg Pro Glu Phe Val Gly Leu 
     130                135                140
Trp Leu Gly Leu Ala Lys Ala Gly Val Val Ala Ala Leu Leu Asn Val 
 145                150                155                160
Asn Leu Arg Arg Glu Pro Leu Ala Phe Cys Leu Gly Thr Ser Ala Ala 
                 165                170                175
Lys Ala Leu Ile Tyr Gly Gly Glu Met Ala Ala Ala Val Ala Glu Val 
             180                185                190
Ser Glu Gln Leu Gly Lys Ser Leu Leu Lys Phe Cys Ser Gly Asp Leu 
         195                200                205
Gly Pro Glu Ser Val Leu Pro Asp Thr Gln Leu Leu Asp Pro Met Leu 
     210                215                220
Ala Glu Ala Pro Thr Thr Pro Leu Ala Gln Ala Pro Gly Lys Gly Met 
 225                230                235                240
Asp Asp Arg Leu Phe Tyr Ile Tyr Thr Ser Gly Thr Thr Gly Leu Pro 
                 245                250                255
Lys Ala Ala Ile Val Val His Ser Arg Tyr Tyr Arg Ile Ala Ala Phe 
             260                265                270
Gly His His Ser Tyr Ser Met Arg Ala Asn Asp Val Leu Tyr Asp Cys 
         275                280                285
Leu Pro Leu Tyr His Ser Ala Gly Asn Ile Met Gly Val Gly Gln Cys 
     290                295                300
Ile Ile Tyr Gly Leu Thr Val Val Leu Arg Lys Lys Phe Ser Ala Ser 
 305                310                315                320
Arg Phe Trp Asp Asp Cys Val Lys Tyr Asn Cys Thr Val Val Gln Tyr 
                 325                330                335
Ile Gly Glu Ile Cys Arg Tyr Leu Leu Arg Gln Pro Val Arg Asp Val 
             340                345                350
Glu Arg Arg His Arg Val Arg Leu Ala Val Gly Asn Gly Leu Arg Pro 
         355                360                365
Ala Ile Trp Glu Glu Phe Thr Gln Gly Phe Gly Val Arg Gln Ile Gly 
     370                375                380
Glu Phe Tyr Gly Ala Thr Glu Cys Asn Cys Ser Ile Ala Asn Met Asp 
 385                390                395                400
Gly Lys Val Gly Ser Cys Gly Phe Asn Ser Arg Ile Leu Thr His Val 
                 405                410                415
Tyr Pro Ile Arg Leu Val Lys Val Asn Glu Asp Thr Met Glu Pro Leu 
             420                425                430
Arg Asp Ser Gln Gly Leu Cys Ile Pro Cys Gln Pro Gly Glu Pro Gly 
         435                440                445
Leu Leu Val Gly Gln Ile Asn Gln Gln Asp Pro Leu Arg Arg Phe Asp 
     450                455                460
Gly Tyr Val Ser Asp Ser Ala Thr Asn Lys Lys Ile Ala His Ser Val 
 465                470                475                480
Phe Arg Lys Gly Asp Ser Ala Tyr Leu Ser Gly Asp Val Leu Val Met 
                 485                490                495
Asp Glu Leu Gly Tyr Met Tyr Phe Arg Asp Arg Ser Gly Asp Thr Phe 
             500                505                510
Arg Trp Arg Gly Glu Asn Val Ser Thr Thr Glu Val Glu Ala Val Leu 
         515                520                525
Ser Arg Leu Leu Gly Gln Thr Asp Val Ala Val Tyr Gly Val Ala Val 
     530                535                540
Pro Gly Val Glu Gly Lys Ser Gly Met Ala Ala Ile Ala Asp Pro His 
 545                550                555                560
Asn Gln Leu Asp Pro Asn Ser Met Tyr Gln Glu Leu Gln Lys Val Leu 
                 565                570                575
Ala Ser Tyr Ala Gln Pro Ile Phe Leu Arg Leu Leu Pro Gln Val Asp 
             580                585                590
Thr Thr Gly Thr Phe Lys Ile Gln Lys Thr Arg Leu Gln Arg Glu Gly 
         595                600                605
Phe Asp Pro Arg Gln Thr Ser Asp Arg Leu Phe Phe Leu Asp Leu Lys 
     610                615                620
Gln Gly Arg Tyr Leu Pro Leu Asp Glu Arg Val His Ala Arg Ile Cys 
 625                630                635                640
Ala Gly Asp Phe Ser Leu 
                 645



<210> 9059
<211> 794
<212> DNA
<213> Homo sapiens
<308> BG828409
<400> 9059

gaaatgaaa  aaagaaaag  aaaagaggg  agagttaag  ccagacagg  acagggatg  60
aaggagaca  aggctgaaa  gcagggaga  gaggcagac  caggggcac  aaggcagca  120
agaggcacg  gttcctctg  ggttccagt  tctcagtcc  ggatgggcc  tgccaggta  180
agctcggcc  ggtgggtgt  tactaggcg  ccacccctg  gcagcgctg  ctggctcaa  240
ctggcctct  ccaccaggc  cagagtttg  ggccagtag  ggaacagct  cagagggcg  300
aggcgcccg  gcagatgcg  gtgtagact  cctcattta  gggcaggta  tggccctgc  360
tcaggtcca  gaagaagag  cggtctgag  tctggcgtg  gtcaaagcc  tctcgctgc  420
gcctcgtct  ctggatctt  aaggtgcct  gaacagcca  cccatagac  gccacgtct  480
tctggccca  caggcggct  agcacgccc  ccacctcgg  ggtggagac  ttctcccct  540
gccagcgga  ggtgtcccc  ctacggtcc  ggaagtaca  gtagcccag  tcatccatc  600
ctagcacgt  acctgagag  taggcgctg  cgcccttgc  gaagacgct  tgggcgatc  660
tcttgctgg  ggcgctctc  ctgacatag  catcgaagc  ggcgcagcg  gtcctgttg  720
cttgatctg  cccacaacg  aggccaggc  ccccggcct  gcaagggac  gcagaggcc  780
tgggcatcc  gcac  794



<210> 9060
<211> 643
<212> PRT
<213> Homo sapiens
<308> XP_026964
<400> 9060

Met Leu Leu Gly Ala Ser Leu Val Gly Val Leu Leu Phe Ser Lys Leu 
  1               5                  10                  15
Val Leu Lys Leu Pro Trp Thr Gln Val Gly Phe Ser Leu Leu Phe Leu 
             20                  25                  30
Tyr Leu Gly Ser Gly Gly Trp Arg Phe Ile Arg Val Phe Ile Lys Thr 
         35                  40                  45
Ile Arg Arg Asp Ile Phe Gly Gly Leu Val Leu Leu Lys Val Lys Ala 
     50                  55                  60
Lys Val Arg Gln Cys Leu Gln Glu Arg Arg Thr Val Pro Ile Leu Phe 
 65                  70                  75                  80
Ala Ser Thr Val Arg Arg His Pro Asp Lys Thr Ala Leu Ile Phe Glu 
                 85                  90                  95
Gly Thr Asp Thr His Trp Thr Phe Arg Gln Leu Asp Glu Tyr Ser Ser 
             100                105                110
Ser Val Ala Asn Phe Leu Gln Ala Arg Gly Leu Ala Ser Gly Asp Val 
         115                120                125
Ala Ala Ile Phe Met Glu Asn Arg Asn Glu Phe Val Gly Leu Trp Leu 
     130                135                140
Gly Met Ala Lys Leu Gly Val Glu Ala Ala Leu Ile Asn Thr Asn Leu 
 145                150                155                160
Arg Arg Asp Ala Leu Leu His Cys Leu Thr Thr Ser Arg Ala Arg Ala 
                 165                170                175
Leu Val Phe Gly Ser Glu Met Ala Ser Ala Ile Cys Glu Val His Ala 
             180                185                190
Ser Leu Asp Pro Ser Leu Ser Leu Phe Cys Ser Gly Ser Trp Glu Pro 
         195                200                205
Gly Ala Val Pro Pro Ser Thr Glu His Leu Asp Pro Leu Leu Lys Asp 
     210                215                220
Ala Pro Lys His Leu Pro Ser Cys Pro Asp Lys Gly Phe Thr Asp Lys 
 225                230                235                240
Leu Phe Tyr Ile Tyr Thr Ser Gly Thr Thr Gly Leu Pro Lys Ala Ala 
                 245                250                255
Ile Val Val His Ser Arg Tyr Tyr Arg Met Ala Ala Leu Val Tyr Tyr 
             260                265                270
Gly Phe Arg Met Arg Pro Asn Asp Ile Val Tyr Asp Cys Leu Pro Leu 
         275                280                285
Tyr His Ser Ala Gly Asn Ile Val Gly Ile Gly Gln Cys Leu Leu His 
     290                295                300
Gly Met Thr Val Val Ile Arg Lys Lys Phe Ser Ala Ser Arg Phe Trp 
 305                310                315                320
Asp Asp Cys Ile Lys Tyr Asn Cys Thr Ile Val Gln Tyr Ile Gly Glu 
                 325                330                335
Leu Cys Arg Tyr Leu Leu Asn Gln Pro Pro Arg Glu Ala Glu Asn Gln 
             340                345                350
His Gln Val Arg Met Ala Leu Gly Asn Gly Leu Arg Gln Ser Ile Trp 
         355                360                365
Thr Asn Phe Ser Ser Arg Phe His Ile Pro Gln Val Ala Glu Phe Tyr 
     370                375                380
Gly Ala Thr Glu Cys Asn Cys Ser Leu Gly Asn Phe Asp Ser Gln Val 
 385                390                395                400
Gly Ala Cys Gly Phe Asn Ser Arg Ile Leu Ser Phe Val Tyr Pro Ile 
                 405                410                415
Arg Leu Val Arg Val Asn Glu Asp Thr Met Glu Leu Ile Arg Gly Pro 
             420                425                430
Asp Gly Val Cys Ile Pro Cys Gln Pro Gly Glu Pro Gly Gln Leu Val 
         435                440                445
Gly Arg Ile Ile Gln Lys Asp Pro Leu Arg Arg Phe Asp Gly Tyr Leu 
     450                455                460
Asn Gln Gly Ala Asn Asn Lys Lys Ile Ala Lys Asp Val Phe Lys Lys 
 465                470                475                480
Gly Asp Gln Ala Tyr Leu Thr Gly Asp Val Leu Val Met Asp Glu Leu 
                 485                490                495
Gly Tyr Leu Tyr Phe Arg Asp Arg Thr Gly Asp Thr Phe Arg Trp Lys 
             500                505                510
Gly Glu Asn Val Ser Thr Thr Glu Val Glu Gly Thr Leu Ser Arg Leu 
         515                520                525
Leu Asp Met Ala Asp Val Ala Val Tyr Gly Val Glu Val Pro Gly Thr 
     530                535                540
Glu Gly Arg Ala Gly Met Ala Ala Val Ala Ser Pro Thr Gly Asn Cys 
 545                550                555                560
Asp Leu Glu Arg Phe Ala Gln Val Leu Glu Lys Glu Leu Pro Leu Tyr 
                 565                570                575
Ala Arg Pro Ile Phe Leu Arg Leu Leu Pro Glu Leu His Lys Thr Gly 
             580                585                590
Thr Tyr Lys Phe Gln Lys Thr Glu Leu Arg Lys Glu Gly Phe Asp Pro 
         595                600                605
Ala Ile Val Lys Asp Pro Leu Phe Tyr Leu Asp Ala Gln Lys Gly Arg 
     610                615                620
Tyr Val Pro Leu Asp Gln Glu Ala Tyr Ser Arg Ile Gln Ala Gly Glu 
 625                630                635                640
Glu Lys Leu 
                 645



<210> 9061
<211> 1114
<212> DNA
<213> Rattus norvegicus
<308> U89745
<400> 9061

tcagtnatc  gccgaattc  cggccgctc  ggcctccac  gttttgtca  tcagttagg  60
ggtgggccc  accttagag  tgggggccc  gccttcact  ttctgttat  cagagggtg  120
ggcctgacc  ccacttttc  gttattcag  gggcagggc  tgacctcca  ttttctgtt  180
ttcaggggg  agggtctga  ctccactgt  ctgtcagtc  tttgggggg  ggggcctgg  240
ggagctata  tgcctgttc  tgaggtggc  ctgcccagt  cagcactgg  ctaaccaca  300
gccaagtgc  gagtaacta  gacccaggc  tgctgggtg  ggggttccg  gaactcatg  360
acctctgtc  tgcctctga  ggactttga  gattgttgc  ctgcagtgt  cctagcagt  420
aaacccagc  gccatgttc  agaggtttc  ccttagctg  tgtgcctct  tgggctggg  480
gggtggttt  aagcatgca  caccaagga  ccagtgtgt  ctttgcttg  ctggaccca  540
cctctgctt  tgctccgtc  tgggaatgc  tctccttat  tcactttcc  ctttcagaa  600
cagaaggac  tgggcctgc  tgaaagctg  gccgtcctt  tttgtgctc  tgccggggc  660
cagtctctg  aaggtggcc  tgagttagg  atccttggt  gaatcctgt  ccactgaac  720
ggtgttaac  ttgaaccac  ctcactctg  gccttggct  ccctttctg  aaaatgggg  780
tractgagc  aaggstgct  gtgggaggr  cacacaggc  tgaggstgg  cctgtgagc  840
tgtgccttt  cttccctcc  tgtgaggtc  tggggagga  ccytgctgg  gcacatgtc  900
ttatccctc  cbcggataa  acacacatt  gtaggkncg  gcgcattyt  acacacaca  960
acacacaca  acacacaca  acacacaca  accccamtn  tcagtgtct  gtgttcatw  1020
cccagntac  cacattccc  gtgcccacc  acactcaca  aggatncct  gctctttaa  1080
ctacaaccc  acacagtcc  ctgcacacc  caaa  1114



<210> 9062
<211> 97
<212> PRT
<213> Rattus norvegicus
<308> AAB49895
<400> 9062

Ser Val Ile Gly Arg Ile Arg Gly Arg Ser Gly Leu His Cys Phe Val 
  1               5                  10                  15
Ser Gln Leu Gly Gly Gly Pro Asn Leu Arg Asp Gly Gly Pro Ala Phe 
             20                  25                  30
Thr Val Leu Leu Phe Arg Gly Trp Gly Leu Thr Ser Thr Phe Leu Leu 
         35                  40                  45
Phe Arg Gly Gln Gly Leu Thr Ser Thr Phe Leu Leu Phe Arg Gly Gln 
     50                  55                  60
Gly Leu Thr Ser Thr Val Leu Ser Val Ile Trp Gly Ala Gly Pro Gly 
 65                  70                  75                  80
Gly Ala Ile Met Pro Val Pro Glu Val Ala Leu Pro Ser Pro Ala Leu 
                 85                  90                  95
Asp 
             100



<210> 9063
<211> 1504
<212> DNA
<213> Rattus norvegicus
<308> U89905
<400> 9063

gctgcgtgg  gtcagggtt  tggagctgg  aggcctggc  ccagggccg  tctgcggga  60
gatcctggc  gacttcggc  ccgaggtgg  gctcgtgga  agactgggc  ccgtgaacc  120
ccccagtca  ctggcccga  gcaagcgct  gctggcgct  gacctgaag  ggtctccgg  180
agccgcggt  ttgcggcgc  tgtgcgcac  cgcggacgt  ttgctggag  ccttccgtt  240
cggtgtcat  gagaaactc  agcttgggc  agagactct  cggcaggac  atccaaagc  300
catctatgc  aggctgagt  gatttggcc  gtcgggaat  ttctccaaa  tagctggcc  360
tgacatcaa  tatgtggct  tgtcaggtg  cctgtcaaa  attggcagg  gcggtgaga  420
cccataccc  cccctgaac  tcctggccg  ctttggtgg  ggtggcctc  tgtgcacat  480
gggcatttt  ctggctctc  tcgaacgca  gcggtctgg  ctagggcag  tcattgatg  540
gaacatggt  gaaggaacg  catacttaa  tactttcct  tggaaaact  aggccatgg  600
tctgtgggc  cagcctcga  ggcaaaacc  gttagatgg  ggggcacct  tctacacaa  660
ctacaagac  gcagatggg  agttcatgg  tgtaggtgc  atagaaccc  agttctaca  720
actgctgct  aaaggactt  gacttgagt  tgaggaact  cccagccag  tgagcatag  780
agattggcc  gaaatgaag  agaaatttg  agatgtgtt  gcaaggaag  ctaaggcag  840
gtggtgcca  atctttgac  ggacagatg  atgtgtgac  ccagtgctg  ctcttgagg  900
ggccctcca  caccagcac  acagagaac  gggctcctt  atcactgat  aggagcagc  960
tgcatgccc  cgtcctgca  cccagcttt  cagaacccc  gctgttcct  ctgccaaaa  1020
ggacccttc  gtgggagag  acactgtag  ggtgcttaa  gactatgga  tcagtcagg  1080
agagatcca  cagctgcac  cggatagaa  cattgaaag  aataagcta  aagccaacc  1140
ctgactcag  ttcacagct  aagtgaatc  gaaggctgt  tctgtactg  agaaggatg  1200
ccaccactg  ccgtatgga  atgtgaatg  acagtaatg  agtaatcca  atattccaa  1260
caagacaca  cgaaagact  attacagag  aatgactgt  ctctcacac  gctcatccg  1320
gcctctgat  gaggagtat  tttgtgtgt  tactgatat  aacttgtgg  agttttctg  1380
ctttcagct  acttggtga  gtgcattca  tgattaaaa  ccttttgta  atgcaactc  1440
gataatata  taaatgaac  aatataact  taataaata  agctttttt  tccttgaaa  1500
aaaa  1504



<210> 9064
<211> 381
<212> PRT
<213> Rattus norvegicus
<308> P70473
<400> 9064

Ala Leu Arg Gly Val Arg Val Leu Glu Leu Ala Gly Leu Ala Pro Gly 
  1               5                  10                  15
Pro Phe Cys Gly Met Ile Leu Ala Asp Phe Gly Ala Glu Val Val Leu 
             20                  25                  30
Val Asp Arg Leu Gly Ser Val Asn His Pro Ser His Leu Ala Arg Gly 
         35                  40                  45
Lys Arg Ser Leu Ala Leu Asp Leu Lys Arg Ser Pro Gly Ala Ala Val 
     50                  55                  60
Leu Arg Arg Met Cys Ala Arg Ala Asp Val Leu Leu Glu Pro Phe Arg 
 65                  70                  75                  80
Cys Gly Val Met Glu Lys Leu Gln Leu Gly Pro Glu Thr Leu Arg Gln 
                 85                  90                  95
Asp Asn Pro Lys Leu Ile Tyr Ala Arg Leu Ser Gly Phe Gly Gln Ser 
             100                105                110
Gly Ile Phe Ser Lys Val Ala Gly His Asp Ile Asn Tyr Val Ala Leu 
         115                120                125
Ser Gly Val Leu Ser Lys Ile Gly Arg Ser Gly Glu Asn Pro Tyr Pro 
     130                135                140
Pro Leu Asn Leu Leu Ala Asp Phe Gly Gly Gly Gly Leu Met Cys Thr 
 145                150                155                160
Leu Gly Ile Leu Leu Ala Leu Phe Glu Arg Thr Arg Ser Gly Leu Gly 
                 165                170                175
Gln Val Ile Asp Ala Asn Met Val Glu Gly Thr Ala Tyr Leu Ser Thr 
             180                185                190
Phe Leu Trp Lys Thr Gln Ala Met Gly Leu Trp Ala Gln Pro Arg Gly 
         195                200                205
Gln Asn Leu Leu Asp Gly Gly Ala Pro Phe Tyr Thr Thr Tyr Lys Thr 
     210                215                220
Ala Asp Gly Glu Phe Met Ala Val Gly Ala Ile Glu Pro Gln Phe Tyr 
 225                230                235                240
Thr Leu Leu Leu Lys Gly Leu Gly Leu Glu Ser Glu Glu Leu Pro Ser 
                 245                250                255
Gln Met Ser Ile Glu Asp Trp Pro Glu Met Lys Lys Lys Phe Ala Asp 
             260                265                270
Val Phe Ala Arg Lys Thr Lys Ala Glu Trp Cys Gln Ile Phe Asp Gly 
         275                280                285
Thr Asp Ala Cys Val Thr Pro Val Leu Thr Leu Glu Glu Ala Leu His 
     290                295                300
His Gln His Asn Arg Glu Arg Gly Ser Phe Ile Thr Asp Glu Glu Gln 
 305                310                315                320
His Ala Cys Pro Arg Pro Ala Pro Gln Leu Ser Arg Thr Pro Ala Val 
                 325                330                335
Pro Ser Ala Lys Arg Asp Pro Ser Val Gly Glu His Thr Val Glu Val 
             340                345                350
Leu Lys Asp Tyr Gly Phe Ser Gln Glu Glu Ile His Gln Leu His Ser 
         355                360                365
Asp Arg Ile Ile Glu Ser Asn Lys Leu Lys Ala Asn Leu 
     370                375                380



<210> 9065
<211> 2946
<212> DNA
<213> Homo sapiens
<308> BC009471
<400> 9065

ctgggaagc  ccatggcac  gcagggcat  tcggtcatg  agctgtccg  cctggcccc  60
ggcccgttc  gtgctatgg  cctggctga  ttcggggcg  gtgtggtac  cgtggaccg  120
cccggctcc  gctacgacg  gagccgctt  ggccggggc  agcgctcgc  agtgctgga  180
ctgaagcag  cgcggggag  cgccgtgct  cggcgtctg  gcaagcggt  ggatgtgct  240
ctggagccc  tccgccgcg  tgtcatgga  aaactccag  tgggcccag  gattctgca  300
cgggaaaat  caaggctta  ttatgccag  ctgagtgga  ttggccagt  aggaagctt  360
tgccggtta  ctggccacg  tatcaacta  ttggctttg  caggtggaa  gaacagcat  420
tttaagttc  tttctgtgg  aaactcaga  atcgagtct  tgggaagca  ctcgaggac  480
gaacatgtt  gatggtgga  cacctttct  tacgactta  aggacagca  atggggaat  540
catggctgt  ggagcaata  aaccccagt  ctacgagct  ctgatcaaa  gacttggac  600
aaagtctga  gaacttccc  atcagatga  catggatga  tggccagaa  tgaagaaga  660
gtttgcaga  gtatttgca  agaagacga  ggcagagtg  tgtcaaatc  ttgacggca  720
agatgcctg  gtgactccg  ttctgactt  tgaggaggt  gttcatcat  atcacaaca  780
ggaacgggg  tcgtttatc  ccagtgagg  gcaggacgt  agcccccgc  ctgcacctc  840
gctgttaaa  accccagcc  tcccttctt  caaaaggga  cctttcata  gagaacaca  900
tgaggagat  cttgaagaa  ttggattca  ccgcgaaga  atttatcag  ttaactcag  960
taaaatcat  gaaagtaat  aggtaaaag  tagtctcta  cttccaggc  cacggctca  1020
gtgaatttg  atactgcat  tacagtgta  agtaacaca  aacattgta  gcatggaaa  1080
atggaggaa  agtattaca  tgtcctacc  ctctaatca  gaaaagaat  acagactct  1140
attctacag  gatgattga  ttctaaaaa  ggttatcat  agggctttt  atttataaa  1200
ctttgggta  ttatactaa  ttatggtag  tattctgcc  tccagtttg  ttgatatat  1260
tgttgatat  aagattctt  acttatatt  tgaatgggt  ctagtgaaa  aggaatgat  1320
tattcttga  gacatcgat  tacatttat  tacactctt  attctacaa  gtagaaaat  1380
aggaaatgc  acaaattgt  tggtgataa  agtcacgtg  aacagagtg  ttggttgca  1440
ccaggcctt  tgtcttggt  ttcatgatc  ccctctaag  acattccaa  ctttagcaa  1500
agttatcac  ctttgtaat  tgcaaagaa  agtttcacc  gtattgaat  agaatgcct  1560
caactgaaa  aaacatatc  aaaataatg  ggaaatgtg  tggctcact  cgtagagtc  1620
agagggaca  tcagtttta  ggttgcctg  atccagtaa  tcggggcct  tttccccgt  1680
ggtctctgg  ctgtcagct  tcctttctc  atgtgtttg  tttctcctc  ggctggtag  1740
aagttctgg  tcttatacc  aacacacag  aacatccag  aataaagat  tcaggaccc  1800
ccagcaagt  gttttgtgt  tccttggac  gagttaagt  acaagcctt  cttatacct  1860
tctttgaca  agaagacgg  attgtcttt  cataaaacc  gcctgctcc  ggagcttcc  1920
tggactcaa  ttcctaaag  catgtgagg  aggggtaga  tccacaatc  aatccgggt  1980
ccatcagag  agagggagt  gagaatgga  gttgggtag  ccatcaata  ggtccattc  2040
gcgcagtat  tcaactgcc  ttcaacaat  gcaagagga  ggtggagca  gtttcttca  2100
cttacagtt  agaaaacag  gactcagaa  ggcttctta  ttcatgttt  ccttagcgc  2160
tcagtgatt  tttcatggt  gcttaggcc  aaagaaata  ctaaccatt  aatttataa  2220
taattaggt  cccaacgaa  taaatatta  gtcctacca  cttattagc  gcttgaaaa  2280
tataataca  ataaataaa  aaatatatt  ttcatttct  tttcattgt  aatcacaac  2340
acttactaa  gagatgtat  cacctattg  acactgtgc  acttctcac  tggaatgag  2400
ttggacact  ctgccctca  tttctgctc  atgttggtg  ccatatagt  cttgatttt  2460
tatcagatg  cctggaaaa  ccagtctca  aaaaatatg  aattatcag  aggattata  2520
tgcaatctt  tgttgaaag  atgaactac  tcactagta  ttcacgtga  gtctgacag  2580
tgttgagtt  cattgtgtt  gtgtgttca  atttttaaa  attctgaga  actcttgtg  2640
ggtcactct  atgccctgg  tgccttggc  cagttttag  aataccagt  gaaaatatt  2700
gctcaggaa  atgcaacta  gaaggggca  aatcagaat  taagctttc  tattctagc  2760
ttcagtctt  ttcttcaac  attttcagg  actttccca  aaggttatg  tttccagcc  2820
aggcatgga  gatcacttg  ggccaagag  tcgagacca  cctggggaa  ttggctgga  2880
ctccgtttc  acgaaataa  aataaaaaa  ttatccagg  aaaaaaaaa  aaaaaaaaa  2940
aaaaaa  2946



<210> 9066
<211> 382
<212> PRT
<213> Homo sapiens
<308> Q9UHK6
<400> 9066

Met Ala Leu Gln Gly Ile Ser Val Val Glu Leu Ser Gly Leu Ala Pro 
  1               5                  10                  15
Gly Pro Phe Cys Ala Met Val Leu Ala Asp Phe Gly Ala Arg Val Val 
             20                  25                  30
Arg Val Asp Arg Pro Gly Ser Arg Tyr Asp Val Ser Arg Leu Gly Arg 
         35                  40                  45
Gly Lys Arg Ser Leu Val Leu Asp Leu Lys Gln Pro Arg Gly Ala Ala 
     50                  55                  60
Val Leu Arg Arg Leu Cys Lys Arg Ser Asp Val Leu Leu Glu Pro Phe 
 65                  70                  75                  80
Arg Arg Gly Val Met Glu Lys Leu Gln Leu Gly Pro Glu Ile Leu Gln 
                 85                  90                  95
Arg Glu Asn Pro Arg Leu Ile Tyr Ala Arg Leu Ser Gly Phe Gly Gln 
             100                105                110
Ser Gly Ser Phe Cys Arg Leu Ala Gly His Asp Ile Asn Tyr Leu Ala 
         115                120                125
Leu Ser Gly Val Leu Ser Lys Ile Gly Arg Ser Gly Glu Asn Pro Tyr 
     130                135                140
Ala Pro Leu Asn Leu Leu Ala Asp Phe Ala Gly Gly Gly Leu Met Cys 
 145                150                155                160
Ala Leu Gly Ile Ile Met Ala Leu Phe Asp Arg Thr Arg Thr Gly Lys 
                 165                170                175
Gly Gln Val Ile Asp Ala Asn Met Val Glu Gly Thr Ala Tyr Leu Ser 
             180                185                190
Ser Phe Leu Trp Lys Thr Gln Lys Ser Ser Leu Trp Glu Ala Pro Arg 
         195                200                205
Gly Gln Asn Met Leu Asp Gly Gly Ala Pro Phe Tyr Thr Thr Tyr Arg 
     210                215                220
Thr Ala Asp Gly Glu Phe Met Ala Val Gly Ala Ile Glu Pro Gln Phe 
 225                230                235                240
Tyr Glu Leu Leu Ile Lys Gly Leu Gly Leu Lys Ser Asp Glu Leu Pro 
                 245                250                255
Asn Gln Met Ser Met Asp Asp Trp Pro Glu Met Lys Lys Lys Phe Ala 
             260                265                270
Asp Val Phe Ala Lys Lys Thr Lys Ala Glu Trp Cys Gln Ile Phe Asp 
         275                280                285
Gly Thr Asp Ala Cys Val Thr Pro Val Leu Thr Phe Glu Glu Val Val 
     290                295                300
His His Asp His Asn Lys Glu Arg Gly Ser Phe Ile Thr Ser Glu Glu 
 305                310                315                320
Gln Asp Val Ser Pro Arg Pro Ala Pro Leu Leu Leu Asn Thr Pro Ala 
                 325                330                335
Ile Pro Ser Phe Lys Arg Asp Pro Phe Ile Gly Glu His Thr Glu Glu 
             340                345                350
Ile Leu Glu Glu Phe Gly Phe Ser Arg Glu Glu Ile Tyr Gln Leu Asn 
         355                360                365
Ser Asp Lys Ile Ile Glu Ser Asn Lys Val Lys Ala Ser Leu 
     370                375                380



<210> 9067
<211> 1504
<212> DNA
<213> Rattus norvegicus
<308> U89905
<400> 9067

gctgcgtgg  gtcagggtt  tggagctgg  aggcctggc  ccagggccg  tctgcggga  60
gatcctggc  gacttcggc  ccgaggtgg  gctcgtgga  agactgggc  ccgtgaacc  120
ccccagtca  ctggcccga  gcaagcgct  gctggcgct  gacctgaag  ggtctccgg  180
agccgcggt  ttgcggcgc  tgtgcgcac  cgcggacgt  ttgctggag  ccttccgtt  240
cggtgtcat  gagaaactc  agcttgggc  agagactct  cggcaggac  atccaaagc  300
catctatgc  aggctgagt  gatttggcc  gtcgggaat  ttctccaaa  tagctggcc  360
tgacatcaa  tatgtggct  tgtcaggtg  cctgtcaaa  attggcagg  gcggtgaga  420
cccataccc  cccctgaac  tcctggccg  ctttggtgg  ggtggcctc  tgtgcacat  480
gggcatttt  ctggctctc  tcgaacgca  gcggtctgg  ctagggcag  tcattgatg  540
gaacatggt  gaaggaacg  catacttaa  tactttcct  tggaaaact  aggccatgg  600
tctgtgggc  cagcctcga  ggcaaaacc  gttagatgg  ggggcacct  tctacacaa  660
ctacaagac  gcagatggg  agttcatgg  tgtaggtgc  atagaaccc  agttctaca  720
actgctgct  aaaggactt  gacttgagt  tgaggaact  cccagccag  tgagcatag  780
agattggcc  gaaatgaag  agaaatttg  agatgtgtt  gcaaggaag  ctaaggcag  840
gtggtgcca  atctttgac  ggacagatg  atgtgtgac  ccagtgctg  ctcttgagg  900
ggccctcca  caccagcac  acagagaac  gggctcctt  atcactgat  aggagcagc  960
tgcatgccc  cgtcctgca  cccagcttt  cagaacccc  gctgttcct  ctgccaaaa  1020
ggacccttc  gtgggagag  acactgtag  ggtgcttaa  gactatgga  tcagtcagg  1080
agagatcca  cagctgcac  cggatagaa  cattgaaag  aataagcta  aagccaacc  1140
ctgactcag  ttcacagct  aagtgaatc  gaaggctgt  tctgtactg  agaaggatg  1200
ccaccactg  ccgtatgga  atgtgaatg  acagtaatg  agtaatcca  atattccaa  1260
caagacaca  cgaaagact  attacagag  aatgactgt  ctctcacac  gctcatccg  1320
gcctctgat  gaggagtat  tttgtgtgt  tactgatat  aacttgtgg  agttttctg  1380
ctttcagct  acttggtga  gtgcattca  tgattaaaa  ccttttgta  atgcaactc  1440
gataatata  taaatgaac  aatataact  taataaata  agctttttt  tccttgaaa  1500
aaaa  1504



<210> 9068
<211> 381
<212> PRT
<213> Rattus norvegicus
<308> P70473
<400> 9068

Ala Leu Arg Gly Val Arg Val Leu Glu Leu Ala Gly Leu Ala Pro Gly 
  1               5                  10                  15
Pro Phe Cys Gly Met Ile Leu Ala Asp Phe Gly Ala Glu Val Val Leu 
             20                  25                  30
Val Asp Arg Leu Gly Ser Val Asn His Pro Ser His Leu Ala Arg Gly 
         35                  40                  45
Lys Arg Ser Leu Ala Leu Asp Leu Lys Arg Ser Pro Gly Ala Ala Val 
     50                  55                  60
Leu Arg Arg Met Cys Ala Arg Ala Asp Val Leu Leu Glu Pro Phe Arg 
 65                  70                  75                  80
Cys Gly Val Met Glu Lys Leu Gln Leu Gly Pro Glu Thr Leu Arg Gln 
                 85                  90                  95
Asp Asn Pro Lys Leu Ile Tyr Ala Arg Leu Ser Gly Phe Gly Gln Ser 
             100                105                110
Gly Ile Phe Ser Lys Val Ala Gly His Asp Ile Asn Tyr Val Ala Leu 
         115                120                125
Ser Gly Val Leu Ser Lys Ile Gly Arg Ser Gly Glu Asn Pro Tyr Pro 
     130                135                140
Pro Leu Asn Leu Leu Ala Asp Phe Gly Gly Gly Gly Leu Met Cys Thr 
 145                150                155                160
Leu Gly Ile Leu Leu Ala Leu Phe Glu Arg Thr Arg Ser Gly Leu Gly 
                 165                170                175
Gln Val Ile Asp Ala Asn Met Val Glu Gly Thr Ala Tyr Leu Ser Thr 
             180                185                190
Phe Leu Trp Lys Thr Gln Ala Met Gly Leu Trp Ala Gln Pro Arg Gly 
         195                200                205
Gln Asn Leu Leu Asp Gly Gly Ala Pro Phe Tyr Thr Thr Tyr Lys Thr 
     210                215                220
Ala Asp Gly Glu Phe Met Ala Val Gly Ala Ile Glu Pro Gln Phe Tyr 
 225                230                235                240
Thr Leu Leu Leu Lys Gly Leu Gly Leu Glu Ser Glu Glu Leu Pro Ser 
                 245                250                255
Gln Met Ser Ile Glu Asp Trp Pro Glu Met Lys Lys Lys Phe Ala Asp 
             260                265                270
Val Phe Ala Arg Lys Thr Lys Ala Glu Trp Cys Gln Ile Phe Asp Gly 
         275                280                285
Thr Asp Ala Cys Val Thr Pro Val Leu Thr Leu Glu Glu Ala Leu His 
     290                295                300
His Gln His Asn Arg Glu Arg Gly Ser Phe Ile Thr Asp Glu Glu Gln 
 305                310                315                320
His Ala Cys Pro Arg Pro Ala Pro Gln Leu Ser Arg Thr Pro Ala Val 
                 325                330                335
Pro Ser Ala Lys Arg Asp Pro Ser Val Gly Glu His Thr Val Glu Val 
             340                345                350
Leu Lys Asp Tyr Gly Phe Ser Gln Glu Glu Ile His Gln Leu His Ser 
         355                360                365
Asp Arg Ile Ile Glu Ser Asn Lys Leu Lys Ala Asn Leu 
     370                375                380



<210> 9069
<211> 2946
<212> DNA
<213> Homo sapiens
<308> BC009471
<400> 9069

ctgggaagc  ccatggcac  gcagggcat  tcggtcatg  agctgtccg  cctggcccc  60
ggcccgttc  gtgctatgg  cctggctga  ttcggggcg  gtgtggtac  cgtggaccg  120
cccggctcc  gctacgacg  gagccgctt  ggccggggc  agcgctcgc  agtgctgga  180
ctgaagcag  cgcggggag  cgccgtgct  cggcgtctg  gcaagcggt  ggatgtgct  240
ctggagccc  tccgccgcg  tgtcatgga  aaactccag  tgggcccag  gattctgca  300
cgggaaaat  caaggctta  ttatgccag  ctgagtgga  ttggccagt  aggaagctt  360
tgccggtta  ctggccacg  tatcaacta  ttggctttg  caggtggaa  gaacagcat  420
tttaagttc  tttctgtgg  aaactcaga  atcgagtct  tgggaagca  ctcgaggac  480
gaacatgtt  gatggtgga  cacctttct  tacgactta  aggacagca  atggggaat  540
catggctgt  ggagcaata  aaccccagt  ctacgagct  ctgatcaaa  gacttggac  600
aaagtctga  gaacttccc  atcagatga  catggatga  tggccagaa  tgaagaaga  660
gtttgcaga  gtatttgca  agaagacga  ggcagagtg  tgtcaaatc  ttgacggca  720
agatgcctg  gtgactccg  ttctgactt  tgaggaggt  gttcatcat  atcacaaca  780
ggaacgggg  tcgtttatc  ccagtgagg  gcaggacgt  agcccccgc  ctgcacctc  840
gctgttaaa  accccagcc  tcccttctt  caaaaggga  cctttcata  gagaacaca  900
tgaggagat  cttgaagaa  ttggattca  ccgcgaaga  atttatcag  ttaactcag  960
taaaatcat  gaaagtaat  aggtaaaag  tagtctcta  cttccaggc  cacggctca  1020
gtgaatttg  atactgcat  tacagtgta  agtaacaca  aacattgta  gcatggaaa  1080
atggaggaa  agtattaca  tgtcctacc  ctctaatca  gaaaagaat  acagactct  1140
attctacag  gatgattga  ttctaaaaa  ggttatcat  agggctttt  atttataaa  1200
ctttgggta  ttatactaa  ttatggtag  tattctgcc  tccagtttg  ttgatatat  1260
tgttgatat  aagattctt  acttatatt  tgaatgggt  ctagtgaaa  aggaatgat  1320
tattcttga  gacatcgat  tacatttat  tacactctt  attctacaa  gtagaaaat  1380
aggaaatgc  acaaattgt  tggtgataa  agtcacgtg  aacagagtg  ttggttgca  1440
ccaggcctt  tgtcttggt  ttcatgatc  ccctctaag  acattccaa  ctttagcaa  1500
agttatcac  ctttgtaat  tgcaaagaa  agtttcacc  gtattgaat  agaatgcct  1560
caactgaaa  aaacatatc  aaaataatg  ggaaatgtg  tggctcact  cgtagagtc  1620
agagggaca  tcagtttta  ggttgcctg  atccagtaa  tcggggcct  tttccccgt  1680
ggtctctgg  ctgtcagct  tcctttctc  atgtgtttg  tttctcctc  ggctggtag  1740
aagttctgg  tcttatacc  aacacacag  aacatccag  aataaagat  tcaggaccc  1800
ccagcaagt  gttttgtgt  tccttggac  gagttaagt  acaagcctt  cttatacct  1860
tctttgaca  agaagacgg  attgtcttt  cataaaacc  gcctgctcc  ggagcttcc  1920
tggactcaa  ttcctaaag  catgtgagg  aggggtaga  tccacaatc  aatccgggt  1980
ccatcagag  agagggagt  gagaatgga  gttgggtag  ccatcaata  ggtccattc  2040
gcgcagtat  tcaactgcc  ttcaacaat  gcaagagga  ggtggagca  gtttcttca  2100
cttacagtt  agaaaacag  gactcagaa  ggcttctta  ttcatgttt  ccttagcgc  2160
tcagtgatt  tttcatggt  gcttaggcc  aaagaaata  ctaaccatt  aatttataa  2220
taattaggt  cccaacgaa  taaatatta  gtcctacca  cttattagc  gcttgaaaa  2280
tataataca  ataaataaa  aaatatatt  ttcatttct  tttcattgt  aatcacaac  2340
acttactaa  gagatgtat  cacctattg  acactgtgc  acttctcac  tggaatgag  2400
ttggacact  ctgccctca  tttctgctc  atgttggtg  ccatatagt  cttgatttt  2460
tatcagatg  cctggaaaa  ccagtctca  aaaaatatg  aattatcag  aggattata  2520
tgcaatctt  tgttgaaag  atgaactac  tcactagta  ttcacgtga  gtctgacag  2580
tgttgagtt  cattgtgtt  gtgtgttca  atttttaaa  attctgaga  actcttgtg  2640
ggtcactct  atgccctgg  tgccttggc  cagttttag  aataccagt  gaaaatatt  2700
gctcaggaa  atgcaacta  gaaggggca  aatcagaat  taagctttc  tattctagc  2760
ttcagtctt  ttcttcaac  attttcagg  actttccca  aaggttatg  tttccagcc  2820
aggcatgga  gatcacttg  ggccaagag  tcgagacca  cctggggaa  ttggctgga  2880
ctccgtttc  acgaaataa  aataaaaaa  ttatccagg  aaaaaaaaa  aaaaaaaaa  2940
aaaaaa  2946



<210> 9070
<211> 382
<212> PRT
<213> Homo sapiens
<308> Q9UHK6
<400> 9070

Met Ala Leu Gln Gly Ile Ser Val Val Glu Leu Ser Gly Leu Ala Pro 
  1               5                  10                  15
Gly Pro Phe Cys Ala Met Val Leu Ala Asp Phe Gly Ala Arg Val Val 
             20                  25                  30
Arg Val Asp Arg Pro Gly Ser Arg Tyr Asp Val Ser Arg Leu Gly Arg 
         35                  40                  45
Gly Lys Arg Ser Leu Val Leu Asp Leu Lys Gln Pro Arg Gly Ala Ala 
     50                  55                  60
Val Leu Arg Arg Leu Cys Lys Arg Ser Asp Val Leu Leu Glu Pro Phe 
 65                  70                  75                  80
Arg Arg Gly Val Met Glu Lys Leu Gln Leu Gly Pro Glu Ile Leu Gln 
                 85                  90                  95
Arg Glu Asn Pro Arg Leu Ile Tyr Ala Arg Leu Ser Gly Phe Gly Gln 
             100                105                110
Ser Gly Ser Phe Cys Arg Leu Ala Gly His Asp Ile Asn Tyr Leu Ala 
         115                120                125
Leu Ser Gly Val Leu Ser Lys Ile Gly Arg Ser Gly Glu Asn Pro Tyr 
     130                135                140
Ala Pro Leu Asn Leu Leu Ala Asp Phe Ala Gly Gly Gly Leu Met Cys 
 145                150                155                160
Ala Leu Gly Ile Ile Met Ala Leu Phe Asp Arg Thr Arg Thr Gly Lys 
                 165                170                175
Gly Gln Val Ile Asp Ala Asn Met Val Glu Gly Thr Ala Tyr Leu Ser 
             180                185                190
Ser Phe Leu Trp Lys Thr Gln Lys Ser Ser Leu Trp Glu Ala Pro Arg 
         195                200                205
Gly Gln Asn Met Leu Asp Gly Gly Ala Pro Phe Tyr Thr Thr Tyr Arg 
     210                215                220
Thr Ala Asp Gly Glu Phe Met Ala Val Gly Ala Ile Glu Pro Gln Phe 
 225                230                235                240
Tyr Glu Leu Leu Ile Lys Gly Leu Gly Leu Lys Ser Asp Glu Leu Pro 
                 245                250                255
Asn Gln Met Ser Met Asp Asp Trp Pro Glu Met Lys Lys Lys Phe Ala 
             260                265                270
Asp Val Phe Ala Lys Lys Thr Lys Ala Glu Trp Cys Gln Ile Phe Asp 
         275                280                285
Gly Thr Asp Ala Cys Val Thr Pro Val Leu Thr Phe Glu Glu Val Val 
     290                295                300
His His Asp His Asn Lys Glu Arg Gly Ser Phe Ile Thr Ser Glu Glu 
 305                310                315                320
Gln Asp Val Ser Pro Arg Pro Ala Pro Leu Leu Leu Asn Thr Pro Ala 
                 325                330                335
Ile Pro Ser Phe Lys Arg Asp Pro Phe Ile Gly Glu His Thr Glu Glu 
             340                345                350
Ile Leu Glu Glu Phe Gly Phe Ser Arg Glu Glu Ile Tyr Gln Leu Asn 
         355                360                365
Ser Asp Lys Ile Ile Glu Ser Asn Lys Val Lys Ala Ser Leu 
     370                375                380



<210> 9071
<211> 5033
<212> DNA
<213> Rattus norvegicus
<308> U90312
<400> 9071

cacgaggcg  cctcgggca  gaccccgcc  cggctcccc  gtgctcccg  cgcccatgg  60
gctgagcaa  gggctgcga  tgctggcgc  gctggaccc  accggcccg  gcagcgtgc  120
gctggaggc  cggggccgc  gcgactgtc  actctttga  gccggcgcg  tggccacgc  180
ggctccgga  gagaaggaa  tcattaaag  actgtatgg  aagccgacg  atgcctatg  240
ctgcctcgg  gagctgagt  taaaatccg  tggcgtccc  ttgagcttt  tggtgttgg  300
gacaggctg  acgtcagtg  gcagaattc  agatgcaga  atctacaaa  tcactggca  360
tgagtttta  cccctgcag  aagaggcca  ggaagagga  cgcctgcca  ccttgaaga  420
aatcctgag  tcaggggtg  tctatttcg  atggcccaa  gatggcgcc  gcttcgatc  480
gaccatcag  gctcagaaa  agggtgatg  ctgctctga  tgggggacc  ccttcttct  540
gaaccagct  ttgcatgtg  ctctgcggc  gcaccaggt  aactgtcat  actggttgc  600
gaaagtcat  tgtggggtg  tgaccatcc  cacggttta  gcctcccac  agcaggcca  660
ggcctgtct  atctctcgc  tcagctgtg  acgcgcagg  gctcgcttc  tcacccggg  720
tgtgaacga  gatggccac  tgtccaact  tgtggagac  gagcaggcg  tttacatgg  780
tgatggagt  tcgtccttt  tccagatcc  aggctccgt  ccgctgttc  gggagcagc  840
agggctcca  gttggctcc  atcatctga  actgcacag  ggcctagag  ccaacgccc  900
tgcttttga  aggcacatg  tgcttctga  ggagcagta  gggcagcag  tggtggtga  960
cctgctggg  agcagaggc  gtgaggagg  gctcaacag  gccttcaag  agttgctct  1020
ggcttcttg  cacgcaggc  acacgccta  gataaattt  gacttccat  agtttgcca  1080
aggtaggaa  ctagagaaa  tggagaacc  gttgagacc  cagttaaaa  tacactggg  1140
tgactttgg  gtatttgcg  agggcgaga  tgtaagtcc  cggtttcag  aaggcactc  1200
gcggatgaa  tgtctcgac  gtctggaca  aaccaacac  gtacagtgc  tcattgctc  1260
tgaggtgct  catctgcag  ttgagagcc  agggctgaa  tccaagccc  tcactgacc  1320
cttcgtgga  tccttcaaa  ccatgtggt  tctgaatgg  catggcctg  gcaaggtgt  1380
cacagggag  agggccctg  aaggaaagg  caaggtggg  aagctgaag  atggggcta  1440
atccatgtc  cgtaccatc  agtccaact  cttcgacgg  gtgaagcag  aggccatca  1500
gctactgct  gttggagat  tctacaatg  agagtctac  gacaaaggc  ggatgctgc  1560
ggacaacac  gcccttctg  gtttggggt  aaataaaca  aacagtctt  caggcatgc  1620
ggatggaaa  gcaacaccc  ggatcctga  ggccatgac  gaacgccag  cagaattca  1680
aaatttcaa  cggatccag  ttgctatgg  gacctggaa  gtgaacgga  gaaaacaat  1740
ccgtagcaa  ctcctgggg  ccactgaac  cactgactg  ctcctggat  caccccagc  1800
ctcaggagc  gtggactct  aggacgatg  cggtcccgc  gacatattt  ccgtcgggt  1860
tgaggagat  gtggagctg  gtgcaggaa  tattgtcaa  gccagcacc  ccaacagga  1920
gatgtgggg  gagcagctc  agaaagcca  ctcccgatc  catcggtac  tcctcttga  1980
ctcagcaca  ctggtgggc  tctgtcttt  catctttgt  cgtccgtac  acgtcccgt  2040
catcaggga  gtggccatc  acaccgtga  gaccggtat  gggggaaag  cagggaata  2100
gggcgccgt  ggtatccgc  ttcagttcc  cagcactag  ttctgcttc  tctgcagtc  2160
cctgacggc  gggcagtct  aggtgaagg  gaggaacga  gactaccgg  agatcacgc  2220
caagctctc  ttcccttcg  ggagaaaca  attttcaca  gattatgtg  tttggtgtg  2280
cgatttcaa  taccgcatc  atcttactt  cgaagaagt  ttctatttt  ttaaacgcc  2340
agactggaa  aaacttatg  aatttgatc  gttacagct  cagaaatca  gtgggaaaa  2400
ttttaaaga  tttcatgaa  gaaccatta  cttcggacc  acctacaag  atgacgttg  2460
atcggctgc  tatgacaca  gtgacaagt  ccggacccc  gcctggaca  acagggtgc  2520
gtggtggag  aagaagcat  cgtacgata  gacagctgg  gaactcaac  ttctagaca  2580
tgatctaga  ggtgatgcc  acatcagac  tacctggtc  ccgggcact  tcaagtact  2640
cggccgtgc  gagctgcag  catctgatc  cagacctgt  ctggccatc  tagaggtgg  2700
ggttcaaga  gtcgatgtg  gagcccggg  gagagtctt  caggaagtg  cctctgtcc  2760
aggcccgct  gacgccact  ttattgtaa  ccttcagtc  ccaaccctt  aagagagaa  2820
tgaatttcc  gaggacctg  gcacagaac  tatgcagac  ttggggaat  atgggacga  2880
tattctggt  aggatcaac  aagggcaga  gctggtgac  tttgcagac  gccactcag  2940
tctcagtgt  ctggatgtg  atggtatga  ggtgaaagg  agggccgtg  agattcgac  3000
aaagaccaa  gattggcta  aaggcttga  agaggagct  attcggaag  gggacagca  3060
ggcccctgt  tctcccacc  ccaactcct  cttgttgga  gagaacttt  acttcacaa  3120
tctggacta  gagtcagaa  gggatgttc  tgaagatga  gaagactac  tagcggatg  3180
gtttggtca  cctgtagtc  cagacagtg  gcttggagg  gacgactct  ctgatacca  3240
gagcgcctc  acacctgcc  gcaagtctc  cgcactggc  aaaaagaag  aacatccaa  3300
gtacaaagc  ggcttaatg  tgaagaagt  tgcctcaga  gcgtctatc  cctccggaa  3360
ccacgggca  tattccatc  tgcagaccg  gaaacttct  ccaggagca  ctcagcaac  3420
gcccaaggc  cgaactgga  taagtaaac  ttacaacgt  aaacagatc  aaaccacca  3480
tgctcagga  gcggaagca  ctatccggt  tctcctgga  gctggcgga  gtgtcccag  3540
gtcagcccc  ggtgccacg  ccctgagaa  ccaagggtc  tctaagcca  aggcctccc  3600
ggggcctcc  gtcctaccg  gccggcctg  tccaagggt  cccactatg  agaaaccaa  3660
tttgaggag  acaggaaag  tcgttttct  ctctagctc  caagcttct  aaccttgct  3720
actgctgca  agacatgag  ttgtaagga  agtagccgc  cagagactg  cacccgtag  3780
tgcttccgg  tcttccgtt  gatctcagt  ctgggagca  gccacttgc  catgttacc  3840
gaagaacag  gtgaacagc  gcctgtcca  tttacaatg  cttcccagg  aatgaacct  3900
gagacccct  ctccaataa  agctcccat  ccgcctgtt  ccaaaccaa  aacatttca  3960
cctgggaga  gtgttgaga  gaggccgag  ggtggcaag  cagaaccgg  tgacgctcc  4020
cctgtgaca  gcgctgtgg  gttatcgtc  ccagaggcc  cagaggccc  gtccctggc  4080
cccaaggtg  ctcctagga  gaagaagtc  gcaccagca  ccttccacc  gcaggtcct  4140
cagagcaac  gccaacttc  gcagggcct  acatgctcc  gcagttctc  gtccccacc  4200
aagcctgac  cccccctgc  ctatccgca  atggcactt  gcacttcat  tgctataag  4260
cccgaaact  atggcccca  agtgacgga  cccgaggca  cctcttttc  tggcgatta  4320
ccagatccc  tctggagcc  tctccacca  cccaagctg  tgaataata  tacctggct  4380
tccaagagc  ctgagcctt  agacttggg  tccaggacc  ctgagagga  acacacaga  4440
tcagcgcag  tcaatgcat  agtggttga  agggggctt  caccagacc  tgggggtaa  4500
gacttcagt  actggatgg  cgccagtaa  aaagacaag  ggacaacat  aggcgtttg  4560
cccacaggc  agaacatgg  ctgttggct  tgtagatgc  ctcatttca  acgctcacc  4620
tcctcatgt  ggcattgct  gacctggtc  aaagggatg  tgatgtaaa  gcacactga  4680
accctttgt  tatctgtca  tctgtgtag  gaatgaaaa  tgtctccca  tcagtacag  4740
tatccagcc  cccaaacgt  ccattcaag  tctgtgcat  ttaagcttg  tctcaggac  4800
ctgggaaat  tgctgttgc  ttcgggata  ggattttaa  gggaagaaa  ctagattcc  4860
aagacgctc  catctgcgg  attttaagt  gttgttcaa  atatgtttg  gtgccattt  4920
cttgttggt  ttgtttgtg  ttttacaga  ttgggataa  tggttaggt  cataaaaga  4980
gacatcaaa  gcagtcggg  ccttaagag  tgttgtgac  cacttgaaa  cac  5033



<210> 9072
<211> 1248
<212> PRT
<213> Rattus norvegicus
<308> O55207
<400> 9072

Met Ala Leu Ser Lys Gly Leu Arg Leu Leu Ala Arg Leu Asp Pro Thr 
  1               5                  10                  15
Gly Pro Ser Ser Val Leu Leu Glu Ala Arg Gly Arg Gly Asp Cys Leu 
             20                  25                  30
Leu Phe Glu Ala Gly Ala Val Ala Thr Leu Ala Pro Glu Glu Lys Glu 
         35                  40                  45
Val Ile Lys Gly Leu Tyr Gly Lys Pro Thr Asp Ala Tyr Gly Cys Leu 
     50                  55                  60
Gly Glu Leu Ser Leu Lys Ser Gly Gly Val Pro Leu Ser Phe Leu Val 
 65                  70                  75                  80
Leu Val Thr Gly Cys Thr Ser Val Gly Arg Ile Pro Asp Ala Glu Ile 
                 85                  90                  95
Tyr Lys Ile Thr Gly Thr Glu Phe Tyr Pro Leu Gln Glu Glu Ala Lys 
             100                105                110
Glu Glu Asp Arg Leu Pro Ala Leu Lys Lys Ile Leu Ser Ser Gly Val 
         115                120                125
Phe Tyr Phe Ala Trp Pro Asn Asp Gly Ala Cys Phe Asp Leu Thr Ile 
     130                135                140
Arg Ala Gln Lys Gln Gly Asp Asp Cys Ser Glu Trp Gly Thr Ser Phe 
 145                150                155                160
Phe Trp Asn Gln Leu Leu His Val Pro Leu Arg Gln His Gln Val Asn 
                 165                170                175
Cys His Asp Trp Leu Leu Lys Val Ile Cys Gly Val Val Thr Ile Arg 
             180                185                190
Thr Val Tyr Ala Ser His Lys Gln Ala Lys Ala Cys Leu Ile Ser Arg 
         195                200                205
Ile Ser Cys Glu Arg Ala Gly Ala Arg Phe Leu Thr Arg Gly Val Asn 
     210                215                220
Asp Asp Gly His Val Ser Asn Phe Val Glu Thr Glu Gln Ala Ile Tyr 
 225                230                235                240
Met Asp Asp Gly Val Ser Ser Phe Val Gln Ile Arg Gly Ser Val Pro 
                 245                250                255
Leu Phe Trp Glu Gln Pro Gly Leu Gln Val Gly Ser His His Leu Arg 
             260                265                270
Leu His Arg Gly Leu Glu Ala Asn Ala Pro Ala Phe Glu Arg His Met 
         275                280                285
Val Leu Leu Lys Glu Gln Tyr Gly Gln Gln Val Val Val Asn Leu Leu 
     290                295                300
Gly Ser Arg Gly Gly Glu Glu Val Leu Asn Arg Ala Phe Lys Lys Leu 
 305                310                315                320
Leu Trp Ala Ser Cys His Ala Gly Asp Thr Pro Met Ile Asn Phe Asp 
                 325                330                335
Phe His Gln Phe Ala Lys Gly Arg Lys Leu Glu Lys Leu Glu Asn Leu 
             340                345                350
Leu Arg Pro Gln Leu Lys Leu His Trp Asp Asp Phe Gly Val Phe Ala 
         355                360                365
Lys Gly Glu Asn Val Ser Pro Arg Phe Gln Lys Gly Thr Leu Arg Met 
     370                375                380
Asn Cys Leu Asp Cys Leu Asp Arg Thr Asn Thr Val Gln Cys Phe Ile 
 385                390                395                400
Ala Leu Glu Val Leu His Leu Gln Leu Glu Ser Leu Gly Leu Asn Ser 
                 405                410                415
Lys Pro Ile Thr Asp Arg Phe Val Glu Ser Phe Lys Ala Met Trp Ser 
             420                425                430
Leu Asn Gly His Gly Leu Ser Lys Val Phe Thr Gly Ser Arg Ala Leu 
         435                440                445
Glu Gly Lys Ala Lys Val Gly Lys Leu Lys Asp Gly Ala Arg Ser Met 
     450                455                460
Ser Arg Thr Ile Gln Ser Asn Phe Phe Asp Gly Val Lys Gln Glu Ala 
 465                470                475                480
Ile Lys Leu Leu Leu Val Gly Asp Val Tyr Asn Glu Glu Ser Thr Asp 
                 485                490                495
Lys Gly Arg Met Leu Leu Asp Asn Thr Ala Leu Leu Gly Leu Gly Ser 
             500                505                510
Asn Lys Gln Asn Ser Leu Ser Gly Met Leu Asp Gly Lys Ala Thr Pro 
         515                520                525
Arg Ile Leu Lys Ala Met Thr Glu Arg Gln Ser Glu Phe Thr Asn Phe 
     530                535                540
Lys Arg Ile Gln Ile Ala Met Gly Thr Trp Asn Val Asn Gly Gly Lys 
 545                550                555                560
Gln Phe Arg Ser Asn Leu Leu Gly Thr Thr Glu Leu Thr Asp Trp Leu 
                 565                570                575
Leu Asp Ala Pro Gln Leu Ser Gly Ala Val Asp Ser Gln Asp Asp Gly 
             580                585                590
Gly Pro Ala Asp Ile Phe Ala Val Gly Phe Glu Glu Met Val Glu Leu 
         595                600                605
Ser Ala Gly Asn Ile Val Asn Ala Ser Thr Thr Asn Arg Lys Met Trp 
     610                615                620
Gly Glu Gln Leu Gln Lys Ala Ile Ser Arg Ser His Arg Tyr Ile Leu 
 625                630                635                640
Leu Thr Ser Ala Gln Leu Val Gly Val Cys Leu Tyr Ile Phe Val Arg 
                 645                650                655
Pro Tyr His Val Pro Phe Ile Arg Asp Val Ala Ile Asp Thr Val Lys 
             660                665                670
Thr Gly Met Gly Gly Lys Ala Gly Asn Lys Gly Ala Val Gly Ile Arg 
         675                680                685
Phe Gln Phe His Ser Thr Ser Phe Cys Phe Ile Cys Ser His Leu Thr 
     690                695                700
Ala Gly Gln Ser Gln Val Lys Glu Arg Asn Glu Asp Tyr Arg Glu Ile 
 705                710                715                720
Thr His Lys Leu Ser Phe Pro Ser Gly Arg Asn Ile Phe Ser His Asp 
                 725                730                735
Tyr Val Phe Trp Cys Gly Asp Phe Asn Tyr Arg Ile Asp Leu Thr Tyr 
             740                745                750
Glu Glu Val Phe Tyr Phe Val Lys Arg Gln Asp Trp Lys Lys Leu Met 
         755                760                765
Glu Phe Asp Gln Leu Gln Leu Gln Lys Ser Ser Gly Lys Ile Phe Lys 
     770                775                780
Asp Phe His Glu Gly Thr Ile Asn Phe Gly Pro Thr Tyr Lys Tyr Asp 
 785                790                795                800
Val Gly Ser Ala Ala Tyr Asp Thr Ser Asp Lys Cys Arg Thr Pro Ala 
                 805                810                815
Trp Thr Asp Arg Val Leu Trp Trp Arg Lys Lys His Pro Tyr Asp Lys 
             820                825                830
Thr Ala Gly Glu Leu Asn Leu Leu Asp Ser Asp Leu Asp Gly Asp Ala 
         835                840                845
Asn Ile Arg His Thr Trp Ser Pro Gly Thr Leu Lys Tyr Tyr Gly Arg 
     850                855                860
Ala Glu Leu Gln Ala Ser Asp His Arg Pro Val Leu Ala Ile Val Glu 
 865                870                875                880
Val Glu Val Gln Glu Val Asp Val Gly Ala Arg Glu Arg Val Phe Gln 
                 885                890                895
Glu Val Ser Ser Val Gln Gly Pro Leu Asp Ala Thr Val Ile Val Asn 
             900                905                910
Leu Gln Ser Pro Thr Leu Glu Glu Arg Asn Glu Phe Pro Glu Asp Leu 
         915                920                925
Arg Thr Glu Leu Met Gln Thr Leu Gly Asn Tyr Gly Thr Ile Ile Leu 
     930                935                940
Val Arg Ile Asn Gln Gly Gln Met Leu Val Thr Phe Ala Asp Ser His 
 945                950                955                960
Ser Ala Leu Ser Val Leu Asp Val Asp Gly Met Lys Val Lys Gly Arg 
                 965                970                975
Ala Val Lys Ile Arg Pro Lys Thr Lys Asp Trp Leu Glu Gly Leu Arg 
             980                985                990
Glu Glu Leu Ile Arg Lys Arg Asp Ser Met Ala Pro Val Ser Pro Thr 
         995                1000                1005
Ala Asn Ser Cys Leu Leu Glu Glu Asn Phe Asp Phe Thr Ser Leu Asp 
     1010                1015                1020
Tyr Glu Ser Glu Gly Asp Val Leu Glu Asp Asp Glu Asp Tyr Leu Ala 
 1025                1030                1035                1040
Asp Glu Phe Gly Gln Pro Val Val Ser Asp Ser Glu Leu Gly Gly Asp 
                 1045                1050                1055
Asp Ser Ser Asp Thr Met Ser Ala Ser Thr Pro Ala Ser Lys Ser Pro 
             1060                1065                1070
Ala Leu Ala Lys Lys Lys Gln His Pro Thr Tyr Lys Ala Gly Leu Met 
         1075                1080                1085
Val Lys Lys Ser Ala Ser Asp Ala Ser Ile Ser Ser Gly Thr His Gly 
     1090                1095                1100
Gln Tyr Ser Ile Leu Gln Thr Ala Lys Leu Leu Pro Gly Ala Pro Gln 
 1105                1110                1115                1120
Gln Pro Pro Lys Ala Arg Thr Gly Ile Ser Lys Pro Tyr Asn Val Lys 
                 1125                1130                1135
Gln Ile Lys Thr Thr Asn Ala Gln Glu Ala Glu Ala Ala Ile Arg Cys 
             1140                1145                1150
Leu Leu Glu Ala Gly Gly Gly Val Pro Glu Ser Ala Pro Gly Ala Thr 
         1155                1160                1165
Pro Leu Arg Asn Gln Gly Ser Ser Lys Pro Glu Ala Ser Leu Gly Pro 
     1170                1175                1180
Pro Val Leu Pro Arg Arg Pro Val Pro Arg Val Pro Thr Met Lys Lys 
 1185                1190                1195                1200
Pro Thr Leu Arg Arg Thr Gly Lys Ile Val Phe Cys Ser Ser Ser Gln 
                 1205                1210                1215
Ala Ser Gln Pro Cys Ser Leu Leu Gln Arg His Glu Phe Val Arg Thr 
             1220                1225                1230
Val Ala Ala Gln Arg Leu Thr Pro Val Asp Ala Ser Gly Ser Ser Val 
         1235                1240                1245



<210> 9073
<211> 6799
<212> DNA
<213> Homo sapiens
<308> AL157424
<400> 9073

ctagatata  tgggaggtg  tttatagaa  gtgcagcat  tcctttgtc  gattccaaa  60
aaatgtaga  gtctacgct  gctagtagt  atggcagct  ggaggtgca  gttctctcc  120
cccaggctc  ttttccacg  tttgggtca  gggggacag  tggtcctgg  ctgtggcac  180
aagaaagca  gactcctgc  ccgtcttcc  ttgaggggc  gaacagggc  gagtctgca  240
ctgtgcccg  gcccagcat  acgcccacc  cgctgcctt  gcaggcaca  ggtgcttct  300
aaggagcag  acgggcagc  ggtggtcgt  aaccttctg  gaagcagag  cggagagga  360
gtgctcaac  gagccttca  gaagctgct  tgggcttct  gccacgcgg  cgacacgcc  420
atgatcaat  ttgacttcc  tcagtttgc  aaaggtggg  agctagaga  attggagac  480
ctcttgagg  cacagttaa  gctgcactg  gaagacttc  atgtgttca  aaaggggga  540
aacgtcagt  cacggtgag  ctcgctgcg  actgtgccg  gtcttctgc  ggggggaag  600
gtcagtcca  gttttcaga  aggcacttt  cggatgaac  gtcttgact  cctggaccg  660
accaacact  tgcagagct  catcgcgct  gaggtcctg  atctgcagc  caagaccct  720
gggctgagt  caaaaccca  cgttgaccg  tttgtggag  ccttcaaag  catgtggtc  780
ctgaatggc  acagcctga  caaggtgtt  acaggcagc  gagccctgg  agggaaggc  840
aaggtgggg  agctgaagg  tggagcccg  tccatgtct  gaaccatcc  gtccaactt  900
ttcgacggg  tgaagcagg  ggccatcaa  ctgctgctg  ttggggacg  ctacggcga  960
gaggtggca  acaaagggg  catgctgct  gacagcacg  cgctcctgg  gactcccag  1020
atcctgaaa  ctatgactg  gcgtcagtc  gaattcaca  atttcaagc  gatccggat  1080
gctatgggg  cctggaacg  gaacggagg  aagcagttc  ggagcaacg  gctcaggac  1140
gcggagctg  cagactggc  gctcgactc  ccccagctc  cgggagcta  cgactccca  1200
gatgacagc  gcccagctg  catatttgc  gtggggttt  aagagatgg  ggaattgag  1260
gcagggaat  ttgtcaatg  cagtactac  aacaagaag  tgtggggtg  acagcttca  1320
aaagccatc  cacgctctc  tagatacat  ctgttgact  cggcacagc  ggtgggcgt  1380
tgtctttat  tctttgtac  tccatacca  gtcccgttc  tcagggacg  agccatcga  1440
acagtgaag  cgggcatgg  gggcaaggc  gggaacaag  gcgccgtcg  catccgctt  1500
cagttccac  gcaccagct  ctgcttcat  tgtagtcac  tgacggccg  gcagtccca  1560
gtgaaggag  ggaatgaag  ctacaagga  atcacccag  aactctgct  cccaatggg  1620
agaaatgtt  tttctcatg  ttatgtatt  tggtgtggc  atttcaact  ccgcattga  1680
cttacttat  aagaagtct  ctattttgt  aaacgccaa  actggaaga  acttctgga  1740
tttgatcaa  tacagctac  gaaatcaag  ggaaaaatt  ttaaggact  tcacgaagg  1800
gccattaac  ttggaccca  ctacaagta  gacgttggc  cagccgcct  cgatacaag  1860
gacaaatgc  gcacccccg  ctggacaga  agggtgctg  ggtggagga  gaaacatcc  1920
tttgataaa  cagctggag  actcaacct  ctagacagt  atctagatg  tgacaccaa  1980
gtcagacac  cctggtctc  tggtgccct  cagtattat  gtcgtgcgg  gctacaagc  2040
tctgatcac  gacctgtgc  ggcgatcgt  gaggtggaa  ttcaggaag  cgatgtggg  2100
gctcgggag  gggttttcc  ggaagtgtc  tccttccag  gccccctgg  tgccactgt  2160
gtagtaaac  ttcaatcac  gaccttaga  gagaaaaac  agtttccag  ggacctgcg  2220
actgagctc  tgcagacct  ggggagtta  gggacaatt  ttcttgtca  gatcaacca  2280
gggcagatg  tggtaactt  tgcagacag  cactcggct  tcagtgtcc  ggacgtgga  2340
ggtatgaag  tgaaaggca  agcagtgaa  attagaccg  agaccaagg  ctggctgaa  2400
ggtttgcga  aggagatca  tcggaaacg  gacagcatg  cccccgtgt  tcccactgc  2460
aactcctgt  tgctggagg  aaactttga  ttcacaagt  tggactatg  gtcagaagg  2520
gatattctt  aagacgatg  agactactt  gtggatgaa  tcaatcagc  tggggtctc  2580
gacagtgaa  tcgggggag  cgacctctc  gatgtcccc  gccccacag  actggctcc  2640
cccagcaag  cacctgctc  caccaaaaa  aagcagcat  caacgtaca  agatgacgc  2700
gacctggtg  agctcaagc  ggagctgga  gccgtcggg  agttccgcc  ccgttctcc  2760
agcaggtct  tgtcggtcc  caaccggcc  cggccacct  aaccccccg  agagacccc  2820
ccctccaac  ggtttaatg  tgaaaaagt  ggcttcaga  gcgtccatc  cctccggca  2880
ccatgggca  tattcaatt  tgcagacgg  aagacttct  ccaggagca  ctcagcaac  2940
tcccaaggc  cggactgga  taagtaaac  ttataatgt  aagcagatc  aaaccacca  3000
tgcccagga  gcagaagca  caaatccgg  gtctcctgg  agccagagg  ggtgcctcc  3060
aagaagccc  aagtgccgt  gccccaagg  accttgaag  atcctctga  ccagagccc  3120
caccggggg  agccaaacc  gagacccca  aggcgcccc  actccttcc  cgtcggccc  3180
cacccagag  tcctgccat  aagaagcca  ccttgagaa  gacaggaaa  cccctgtca  3240
cggaagaac  gtttgagca  cagactgtc  attttacaa  cgggccccc  gagacaagc  3300
ttgaggccc  tcctgtcgt  acagcccct  gagtccctc  tgttcccaa  ccaagaaca  3360
ttcagcctg  gaaagctgc  gagaggcca  gccacagga  gccagcatc  gacgaagcc  3420
ctcctgggg  aggagcctc  gtgccacca  ctctggagg  gccgcctct  gtgcccaag  3480
tacccccga  gaggaagaa  tcagccccc  cagccttcc  cctgcaggt  ctgcagagc  3540
acagccagc  tctccaggg  ctcacttac  atagcagtg  cagcccctc  gggcaccca  3600
ctgcgcggg  accgtcttc  cacaagggg  ctttctcag  acttcatct  ctacaagcc  3660
cgacagcga  ggcaccaaa  cgatgaagc  agaggcagc  ccacttctt  gtgattatc  3720
ggacccctt  tggaacctt  ttcaccacc  taaactgtt  aataacact  ggctttcta  3780
gagctcaga  cctttggac  caggaacca  gagccccaa  agagatccc  tagacccag  3840
gtcagctgg  gcttcagct  ccaaggcag  gctgccacc  gatcatgaa  acaaaacct  3900
aggtcactg  gtgacaatc  gtgaccaag  aaagaggac  gcactgcag  tgtttgacc  3960
actggcaaa  acatgactg  gcagctttg  aggctgcag  cctatagaa  gcatacctt  4020
ctccctcta  acatccctc  accagaaga  acatctatt  aaaggcaca  tggccaaaa  4080
gtttgtgca  ctgtcactc  cgtgtagtt  acaaaaatc  tgtctctta  tcagtaaga  4140
ggttactca  ccaccaaaa  atatttcac  caaggcttg  acatctgaa  tttgctctt  4200
aaggaatgg  aaccttcct  ttaaattcg  tgtatggat  ttaagaaag  aatctagcc  4260
atgaggtcc  agaagttct  acccattga  tttttaaat  gctgttcag  tcatgttgt  4320
cgtgatgga  atttgtctt  tgttttatt  gcattttac  gatttggta  aacattttg  4380
ggagccacc  gaaggttga  gtataaagt  aggattaga  aaagaggtc  ttgtgacca  4440
tagtagctg  cctggccca  ttaaacaag  ttacaaaaa  tcagagtcg  aagcagcca  4500
ataggtcaa  ctaatgact  gactgtaca  tcccatgag  cttcatgtt  aagtgtgta  4560
atgtgcgtt  accttgatg  tgcgtgaat  ccgagggag  cggtggcat  caccgttag  4620
ttaacctta  cttaaacta  ctgaaggct  ctgtgccat  tcttagaca  tgcatgccc  4680
atcaattac  ataatcctg  gccatggtg  gctactgaa  ccaattttt  tccaccatc  4740
agtccttat  aaatgaaac  tcacggatc  tttgttccg  ttatattcc  tgcatacca  4800
ataaaagca  acagtgcga  aactcttgc  gatacgcga  attgattct  attgttaga  4860
tatggagag  gtttcagcc  cgtctgtcc  gctggagct  cgggatgga  agtgctatg  4920
gtccctgca  ataagaatc  ccaggccag  gtttctggg  ttgcttgtc  atatgtttg  4980
ctatatttt  tgcctatac  tttttccca  gtttccaac  gcacttctc  cctattcaa  5040
aactgaaaa  gacattacc  tagtgcttt  catttttaa  gtaatgtta  aaggtctgg  5100
atccatttg  agcagatac  gtgttttcg  tatttaata  gaagttcag  agtgaaatc  5160
tactgtacc  cctgttgta  ctgggagcc  cgtacagag  ctcgcacag  agtgatcag  5220
tgtcatccc  tacgtgact  ggggatgtc  gtcctaaaa  ctgactgct  ggatagtaa  5280
gatcatctt  cctgggcta  gccactgtc  tgttaccaa  tagacatct  gaatttcat  5340
attagtttt  attgtcact  tcaagatat  ttgcagatt  cttaaatat  gccatcaaa  5400
caaaagtta  aacacgtat  tcttttcat  tgaaaacta  tacctggaa  aggataaaa  5460
aaaaaaaag  aatccgtga  ccacagagc  agacagata  gatgcatag  tgaccagtc  5520
taaaaggcg  tgtttaggt  atcaggatg  cgttggtgg  atttacgtg  tttatatga  5580
ttttacctc  gtaacaaac  caagaaata  acagaatgg  ccttaacag  gtttggggg  5640
gagagcaag  tgggttcct  ggagaagct  atttgccaa  atgcacatc  ctattaaca  5700
ccagagtca  aaatgaaat  aaattgaag  attcattca  atgctcttt  ccctataac  5760
tcttttctc  ccaaaaagg  gataaattt  aaaacagat  aatgtaaca  ccagtcaaa  5820
aagcagggg  aaagtaagc  cctccaaag  tgcttgcag  gctggaaat  gatctcatt  5880
ttaggtttt  tcttcgttc  agataccaa  taaatggga  agagaataa  atttttgtt  5940
aaatatgtg  tcatctcct  agtagctct  cagagtctg  ccgtaagta  aaacacaca  6000
aattgtgtt  actggggga  gtgaatcac  aaaaagtta  gaggagttt  agagttaaa  6060
attatttga  cgtggctgt  aaatttagt  aacaacata  attggattt  gagttggta  6120
taggtatgg  tctcatacc  gaattctct  aaaaaaaaa  aaaaggaca  ttggaattg  6180
cttatttat  tttaaaatc  atgcttact  gttggtagg  ttcccaggt  agcagcagg  6240
ttgattaaa  aatcttgac  atgagcagc  gccatcttg  gggattttc  ttctgtggt  6300
ttttaaatg  ttcgtcttt  atgctacca  ccagggctt  ttattgtga  cttgtagcc  6360
attttgttc  tgctgttct  taacatggt  cagttcacg  agactggtt  aggtacttc  6420
caactcacc  ttgtctctc  gaccccaag  ctagtccct  ttacatcac  atcttctca  6480
acttcttgc  tattcttaa  atatgtttt  gttaatgat  gaattagga  atcagctta  6540
gcaattcct  taacggttt  acgttgttg  agttcaagg  acataataa  attctccct  6600
atgtgtgtg  aagtataaa  aaagtaatg  atcaaagcg  tcactttat  atgaagtca  6660
ttcattggg  aggaaagct  caaagatta  tgggggact  gtgattaat  aaatcctgt  6720
atatttttg  agtgaaaat  tgtactgaa  ttgtacatg  tacctatta  atgtttttg  6780
cttttttca  aaaaaaaaa  6799



<210> 9074
<211> 1443
<212> PRT
<213> Homo sapiens
<308> O15056
<400> 9074

Tyr Gly Lys Leu Thr Asp Ala Tyr Gly Cys Leu Gly Glu Leu Arg Leu 
  1               5                  10                  15
Lys Ser Gly Gly Thr Ser Leu Ser Phe Leu Val Leu Val Thr Gly Cys 
             20                  25                  30
Thr Ser Val Gly Arg Ile Pro Asp Ala Glu Ile Tyr Lys Ile Thr Ala 
         35                  40                  45
Thr Asp Phe Tyr Pro Leu Gln Glu Glu Ala Lys Glu Glu Glu Arg Leu 
     50                  55                  60
Ile Ala Leu Lys Lys Ile Leu Ser Ser Gly Val Phe Tyr Phe Ser Trp 
 65                  70                  75                  80
Pro Asn Asp Gly Ser Arg Phe Asp Leu Thr Val Arg Thr Gln Lys Gln 
                 85                  90                  95
Gly Asp Asp Ser Ser Glu Trp Gly Asn Ser Phe Phe Trp Asn Gln Leu 
             100                105                110
Leu His Val Pro Leu Arg Gln His Gln Val Ser Cys Cys Asp Trp Leu 
         115                120                125
Leu Lys Ile Ile Cys Gly Val Val Thr Ile Arg Thr Val Tyr Ala Ser 
     130                135                140
His Lys Gln Ala Lys Ala Cys Leu Val Ser Arg Val Ser Cys Glu Arg 
 145                150                155                160
Thr Gly Thr Arg Phe His Thr Arg Gly Val Asn Asp Asp Gly His Val 
                 165                170                175
Ser Asn Phe Val Glu Thr Glu Gln Met Ile Tyr Met Asp Asp Gly Val 
             180                185                190
Ser Ser Phe Val Gln Ile Arg Gly Ser Val Pro Leu Phe Trp Glu Gln 
         195                200                205
Pro Gly Leu Gln Val Gly Ser His His Leu Arg Leu His Arg Gly Leu 
     210                215                220
Glu Ala Asn Ala Pro Ala Phe Asp Arg His Met Val Leu Leu Lys Glu 
 225                230                235                240
Gln Tyr Gly Gln Gln Val Val Val Asn Leu Leu Gly Ser Arg Gly Gly 
                 245                250                255
Glu Glu Val Leu Asn Arg Ala Phe Lys Lys Leu Leu Trp Ala Ser Cys 
             260                265                270
His Ala Gly Asp Thr Pro Met Ile Asn Phe Asp Phe His Gln Phe Ala 
         275                280                285
Lys Gly Gly Lys Leu Glu Lys Leu Glu Thr Leu Leu Arg Pro Gln Leu 
     290                295                300
Lys Leu His Trp Glu Asp Phe Asp Val Phe Thr Lys Gly Glu Asn Val 
 305                310                315                320
Ser Pro Arg Phe Gln Lys Gly Thr Leu Arg Met Asn Cys Leu Asp Cys 
                 325                330                335
Leu Asp Arg Thr Asn Thr Val Gln Ser Phe Ile Ala Leu Glu Val Leu 
             340                345                350
His Leu Gln Leu Lys Thr Leu Gly Leu Ser Ser Lys Pro Ile Val Asp 
         355                360                365
Arg Phe Val Glu Ser Phe Lys Ala Met Trp Ser Leu Asn Gly His Ser 
     370                375                380
Leu Ser Lys Val Phe Thr Gly Ser Arg Ala Leu Glu Gly Lys Ala Lys 
 385                390                395                400
Val Gly Lys Leu Lys Asp Gly Ala Arg Ser Met Ser Arg Thr Ile Gln 
                 405                410                415
Ser Asn Phe Phe Asp Gly Val Lys Gln Glu Ala Ile Lys Leu Leu Leu 
             420                425                430
Val Gly Asp Val Tyr Gly Glu Glu Val Ala Asp Lys Gly Gly Met Leu 
         435                440                445
Leu Asp Ser Thr Ala Leu Leu Val Thr Pro Arg Ile Leu Lys Ala Met 
     450                455                460
Thr Glu Arg Gln Ser Glu Phe Thr Asn Phe Lys Arg Ile Arg Ile Ala 
 465                470                475                480
Met Gly Thr Trp Asn Val Asn Gly Gly Lys Gln Phe Arg Ser Asn Val 
                 485                490                495
Leu Arg Thr Ala Glu Leu Thr Asp Trp Leu Leu Asp Ser Pro Gln Leu 
             500                505                510
Ser Gly Ala Thr Asp Ser Gln Asp Asp Ser Ser Pro Ala Asp Ile Phe 
         515                520                525
Ala Val Gly Phe Glu Glu Met Val Glu Leu Ser Ala Gly Asn Ile Val 
     530                535                540
Asn Ala Ser Thr Thr Asn Lys Lys Met Trp Gly Glu Gln Leu Gln Lys 
 545                550                555                560
Ala Ile Ser Arg Ser His Arg Tyr Ile Leu Leu Thr Ser Ala Gln Leu 
                 565                570                575
Val Gly Val Cys Leu Tyr Ile Phe Val Arg Pro Tyr His Val Pro Phe 
             580                585                590
Ile Arg Asp Val Ala Ile Asp Thr Val Lys Thr Gly Met Gly Gly Lys 
         595                600                605
Ala Gly Asn Lys Gly Ala Val Gly Ile Arg Phe Gln Phe His Ser Thr 
     610                615                620
Ser Phe Cys Phe Ile Cys Ser His Leu Thr Ala Gly Gln Ser Gln Val 
 625                630                635                640
Lys Glu Arg Asn Glu Asp Tyr Lys Glu Ile Thr Gln Lys Leu Cys Phe 
                 645                650                655
Pro Met Gly Arg Asn Val Phe Ser His Asp Tyr Val Phe Trp Cys Gly 
             660                665                670
Asp Phe Asn Tyr Arg Ile Asp Leu Thr Tyr Glu Glu Val Phe Tyr Phe 
         675                680                685
Val Lys Arg Gln Asp Trp Lys Lys Leu Leu Glu Phe Asp Gln Leu Gln 
     690                695                700
Leu Gln Lys Ser Ser Gly Lys Ile Phe Lys Asp Phe His Glu Gly Ala 
 705                710                715                720
Ile Asn Phe Gly Pro Thr Tyr Lys Tyr Asp Val Gly Ser Ala Ala Tyr 
                 725                730                735
Asp Thr Ser Asp Lys Cys Arg Thr Pro Ala Trp Thr Asp Arg Val Leu 
             740                745                750
Trp Trp Arg Lys Lys His Pro Phe Asp Lys Thr Ala Gly Glu Leu Asn 
         755                760                765
Leu Leu Asp Ser Asp Leu Asp Val Asp Thr Lys Val Arg His Thr Trp 
     770                775                780
Ser Pro Gly Ala Leu Gln Tyr Tyr Gly Arg Ala Glu Leu Gln Ala Ser 
 785                790                795                800
Asp His Arg Pro Val Leu Ala Ile Val Glu Val Glu Val Gln Glu Val 
                 805                810                815
Asp Val Gly Ala Arg Glu Arg Val Phe Gln Glu Val Ser Ser Phe Gln 
             820                825                830
Gly Pro Leu Asp Ala Thr Val Val Val Asn Leu Gln Ser Pro Thr Leu 
         835                840                845
Glu Glu Lys Asn Glu Phe Pro Glu Asp Leu Arg Thr Glu Leu Met Gln 
     850                855                860
Thr Leu Gly Ser Tyr Gly Thr Ile Val Leu Val Arg Ile Asn Gln Gly 
 865                870                875                880
Gln Met Leu Val Thr Phe Ala Asp Ser His Ser Ala Leu Ser Val Leu 
                 885                890                895
Asp Val Asp Gly Met Lys Val Lys Gly Arg Ala Val Lys Ile Arg Pro 
             900                905                910
Lys Thr Lys Asp Trp Leu Lys Gly Leu Arg Glu Glu Ile Ile Arg Lys 
         915                920                925
Arg Asp Ser Met Ala Pro Val Ser Pro Thr Ala Asn Ser Cys Leu Leu 
     930                935                940
Glu Glu Asn Phe Asp Phe Thr Ser Leu Asp Tyr Glu Ser Glu Gly Asp 
 945                950                955                960
Ile Leu Glu Asp Asp Glu Asp Tyr Leu Val Asp Glu Phe Asn Gln Pro 
                 965                970                975
Gly Val Ser Asp Ser Glu Leu Gly Gly Asp Asp Leu Ser Asp Val Pro 
             980                985                990
Gly Pro Thr Ala Leu Ala Pro Pro Ser Lys Ser Pro Ala Leu Thr Lys 
         995                1000                1005
Lys Lys Gln His Pro Thr Tyr Lys Asp Asp Ala Asp Leu Val Glu Leu 
     1010                1015                1020
Lys Arg Glu Leu Glu Ala Val Gly Glu Phe Arg His Arg Ser Pro Ser 
 1025                1030                1035                1040
Arg Ser Leu Ser Val Pro Asn Arg Pro Arg Pro Pro Gln Pro Pro Gln 
                 1045                1050                1055
Arg Pro Pro Pro Pro Thr Gly Leu Met Val Lys Lys Ser Ala Ser Asp 
             1060                1065                1070
Ala Ser Ile Ser Ser Gly Thr His Gly Gln Tyr Ser Ile Leu Gln Thr 
         1075                1080                1085
Ala Arg Leu Leu Pro Gly Ala Pro Gln Gln Pro Pro Lys Ala Arg Thr 
     1090                1095                1100
Gly Ile Ser Lys Pro Tyr Asn Val Lys Gln Ile Lys Thr Thr Asn Ala 
 1105                1110                1115                1120
Gln Glu Ala Glu Ala Ala Ile Arg Cys Leu Leu Glu Ala Arg Gly Gly 
                 1125                1130                1135
Ala Ser Glu Glu Ala Leu Ser Ala Val Ala Pro Arg Asp Leu Glu Ala 
             1140                1145                1150
Ser Ser Glu Pro Glu Pro Thr Pro Gly Ala Ala Lys Pro Glu Thr Pro 
         1155                1160                1165
Gln Ala Pro Pro Leu Leu Pro Arg Arg Pro Pro Pro Arg Val Pro Ala 
     1170                1175                1180
Ile Lys Lys Pro Thr Leu Arg Arg Thr Gly Lys Pro Leu Ser Pro Glu 
 1185                1190                1195                1200
Glu Gln Phe Glu Gln Gln Thr Val His Phe Thr Ile Gly Pro Pro Glu 
                 1205                1210                1215
Thr Ser Val Glu Ala Pro Pro Val Val Thr Ala Pro Arg Val Pro Pro 
             1220                1225                1230
Val Pro Lys Pro Arg Thr Phe Gln Pro Gly Lys Ala Ala Glu Arg Pro 
         1235                1240                1245
Ser His Arg Lys Pro Ala Ser Asp Glu Ala Pro Pro Gly Ala Gly Ala 
     1250                1255                1260
Ser Val Pro Pro Pro Leu Glu Ala Pro Pro Leu Val Pro Lys Val Pro 
 1265                1270                1275                1280
Pro Arg Arg Lys Lys Ser Ala Pro Ala Ala Phe His Leu Gln Val Leu 
                 1285                1290                1295
Gln Ser Asn Ser Gln Leu Leu Gln Gly Leu Thr Tyr Asn Ser Ser Asp 
             1300                1305                1310
Ser Pro Ser Gly His Pro Pro Ala Ala Gly Thr Val Phe Pro Gln Gly 
         1315                1320                1325
Asp Phe Leu Ser Thr Ser Ser Ala Thr Ser Pro Asp Ser Asp Gly Thr 
     1330                1335                1340
Lys Ala Met Lys Pro Glu Ala Ala Pro Leu Leu Gly Asp Tyr Gln Asp 
 1345                1350                1355                1360
Pro Phe Trp Asn Leu Leu His His Pro Lys Leu Leu Asn Asn Thr Trp 
                 1365                1370                1375
Leu Ser Lys Ser Ser Asp Pro Leu Asp Ser Gly Thr Arg Ser Pro Lys 
             1380                1385                1390
Arg Asp Pro Ile Asp Pro Val Ser Ala Gly Ala Ser Ala Ala Lys Ala 
         1395                1400                1405
Glu Leu Pro Pro Asp His Glu His Lys Thr Leu Gly His Trp Val Thr 
     1410                1415                1420
Ile Ser Asp Gln Glu Lys Arg Thr Ala Leu Gln Val Phe Asp Pro Leu 
 1425                1430                1435                1440
Ala Lys Thr 
                 1445



<210> 9075
<211> 1050
<212> DNA
<213> Rattus norvegicus
<308> U90610
<400> 9075

atggaaata  acacttcgg  taactactc  gaagaagta  ggtctggag  ctatgactc  60
aacaaggaa  cctgcttcc  ggatgaaaa  gaaaacttc  acaggatct  cctgcccac  120
atctatttt  tcatcttct  gactggcat  gtgggcaat  ggttggtaa  cctggtcat  180
ggttaccag  agaagctga  gagcatgac  gacaagtac  ggctgcacc  gtccgtggc  240
gacctcctc  ttgtcatca  actcccctt  tgggcagtg  acgccatgg  tgactggta  300
tttgggaaa  ttttatgta  ggctgtgca  atcatctac  ccgtcaacc  ttacagcag  360
gttctcatc  tggccttca  cagcctgga  cgctacctt  ccattgtcc  cgccaccaa  420
agccagagc  cgaggaagc  gctggctga  aaggccgtc  atgtgggtg  ctggatccc  480
gccctcctc  tgactatcc  tgacatcat  ttcgccgat  tcagccagg  ggacggcag  540
tacatctgt  accgccttt  ccccgacag  ctgtggatg  tggtgttcc  gttccagca  600
atcatggtg  gtctcatcc  gccgggcat  gtcatcctg  cctgttact  catcatcat  660
tccaagctg  cacactcca  gggccacca  aagcgcaag  ccctcaaga  tacggtcat  720
cttatcctg  ctttctttg  ctgctggct  ccgtattac  tggggatca  catcgattc  780
ttcatcctt  tggaggtca  caagcaagg  tgtgagttc  agagcgtcg  gcacaagtg  840
atctccatc  cggaggccc  cgccttctt  cactgttgc  tgaacccca  cctctacgc  900
ttcctcggg  ccaaattca  gagctccgc  cagcatgca  tcaattcca  gagcagagg  960
tccagcctc  agatccttt  caaagggaa  cggggtgga  actcttccg  ctccacaga  1020
tcagaatcc  caagttttc  ctccagctaa  1050



<210> 9076
<211> 349
<212> PRT
<213> Rattus norvegicus
<308> O08565
<400> 9076

Met Glu Ile Tyr Thr Ser Asp Asn Tyr Ser Glu Glu Val Gly Ser Gly 
  1               5                  10                  15
Asp Tyr Asp Ser Asn Lys Glu Pro Cys Phe Arg Asp Glu Asn Glu Asn 
             20                  25                  30
Phe Asn Arg Ile Phe Leu Pro Thr Ile Tyr Phe Ile Ile Phe Leu Thr 
         35                  40                  45
Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly Tyr Gln Lys 
     50                  55                  60
Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu Ser Val Ala 
 65                  70                  75                  80
Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val Asp Ala Met 
                 85                  90                  95
Ala Asp Trp Tyr Phe Gly Lys Phe Leu Cys Lys Ala Val His Ile Ile 
             100                105                110
Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala Phe Ile Ser 
         115                120                125
Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser Gln Ser Ala 
     130                135                140
Arg Lys Leu Leu Ala Glu Lys Ala Val Tyr Val Gly Val Trp Ile Pro 
 145                150                155                160
Ala Leu Leu Leu Thr Ile Pro Asp Ile Ile Phe Ala Asp Val Ser Gln 
                 165                170                175
Gly Asp Gly Arg Tyr Ile Cys Asp Arg Leu Tyr Pro Asp Ser Leu Trp 
             180                185                190
Met Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu Ile Leu Pro 
         195                200                205
Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser Lys Leu Ser 
     210                215                220
His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr Thr Val Ile 
 225                230                235                240
Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr Val Gly Ile 
                 245                250                255
Ser Ile Asp Ser Phe Ile Leu Leu Glu Val Ile Lys Gln Gly Cys Glu 
             260                265                270
Phe Glu Ser Val Val His Lys Trp Ile Ser Ile Thr Glu Ala Leu Ala 
         275                280                285
Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe Leu Gly Ala 
     290                295                300
Lys Phe Lys Ser Ser Ala Gln His Ala Leu Asn Ser Met Ser Arg Gly 
 305                310                315                320
Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly His Ser Ser 
                 325                330                335
Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
             340                345



<210> 9077
<211> 1670
<212> DNA
<213> Homo sapiens
<308> L06797
<400> 9077

cggcacgag  caagtgacg  cgagggcct  agtgctcca  tagccaccg  atctggaga  60
ccagcggtt  ccatggagg  gatcagtat  tacacttca  ataactaca  cgaggaaat  120
ggctcaggg  actatgact  catgaagga  ccctgtttc  gtgaagaaa  tgctaattt  180
aataaaatc  tcctgccca  catctactc  atcatcttc  taactggca  tgtgggcaa  240
ggattggtc  tcctggtca  gggttacca  aagaaactg  gaagcatga  ggacaagta  300
aggctgcac  tgtcagtgg  cgacctcct  tttgtcatc  cgcttccct  ctgggcagt  360
gatgccgtg  caaactggt  ctttgggaa  ttcctatgc  aggcagtcc  tgtcatcta  420
acagtcaac  tctacagca  tgtcctcat  ctggccttc  tcagtctgg  ccgctacct  480
gccatcgtc  acgccacca  cagtcagag  ccaaggaag  tgttggctg  aaaggtggt  540
tatgttggc  tctggatcc  tgccctcct  ctgactatt  ccgacttca  ctttgccaa  600
gtcagtgag  cagatgaca  atatatctg  gaccgcttc  accccaatg  cttgtgggt  660
gttgtgttc  agtttcagc  catcatggt  ggccttatc  tgcctggta  tgtcatcct  720
tcctgctat  gcattatca  ctccaagct  tcacactcc  agggccacc  gaagcgcaa  780
gccctcaag  ccacagtca  cctcatcct  gctttcttc  cctgttggc  gccttacta  840
attgggatc  gcatcgact  cttcatcct  ctggaaatc  tcaagcaag  gtgtgagtt  900
gagaacact  tgcacaagt  gatttccat  accgaggcc  tagctttct  ccactgttg  960
ctgaacccc  tcctctatg  tttccttgg  gccaaattt  aaacctctg  ccagcacgc  1020
ctcacctct  tgagcagag  gtccagcct  aagatcctc  ccaaaggaa  gcgaggtgg  1080
cattcatct  tttccactg  gtctgagtc  tcaagtttt  actccagct  acacagatg  1140
aagagactt  tttttatac  ataaataac  tttttttaa  ttacacatt  ttcagatat  1200
aaagactga  caatattgt  cagttttta  tgcttgttg  atttttgct  ttgtgtttc  1260
ttagttttt  gtgaaggtt  aattgactt  tttatataa  ttttttttg  ttcatattg  1320
tgtgtgtct  ggcaggacc  gtggccaag  tcttagttg  tgtatgtct  gtggtagga  1380
tgtagaaaa  ggaactgaa  attccagag  gtgtagtga  tcacgtaaa  ctagaaatg  1440
tccccagct  tttatgcat  gataatctc  ccattcccg  ggaacgttt  tcctgttct  1500
aagacgtga  tttgctgta  aagatggca  ttataacca  agcccaaag  ggtatagaa  1560
tgctggttt  tcagttttc  ggagtgggt  gatttcagc  cctacagtg  acagtcttg  1620
attaagttg  taataaaag  acatgttaa  cttaaaaaa  aaaaaaaaaa  1670



<210> 9078
<211> 352
<212> PRT
<213> Homo sapiens
<308> P30991
<400> 9078

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
  1               5                  10                  15
Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
             20                  25                  30
Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
         35                  40                  45
Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
     50                  55                  60
Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
 65                  70                  75                  80
Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                 85                  90                  95
Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
             100                105                110
His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
         115                120                125
Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
     130                135                140
Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
 145                150                155                160
Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 
                 165                170                175
Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
             180                185                190
Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
         195                200                205
Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
     210                215                220
Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
 225                230                235                240
Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                 245                250                255
Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
             260                265                270
Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
         275                280                285
Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
     290                295                300
Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
 305                310                315                320
Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                 325                330                335
His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
             340                345                350



<210> 9079
<211> 1050
<212> DNA
<213> Rattus norvegicus
<308> U90610
<400> 9079

atggaaata  acacttcgg  taactactc  gaagaagta  ggtctggag  ctatgactc  60
aacaaggaa  cctgcttcc  ggatgaaaa  gaaaacttc  acaggatct  cctgcccac  120
atctatttt  tcatcttct  gactggcat  gtgggcaat  ggttggtaa  cctggtcat  180
ggttaccag  agaagctga  gagcatgac  gacaagtac  ggctgcacc  gtccgtggc  240
gacctcctc  ttgtcatca  actcccctt  tgggcagtg  acgccatgg  tgactggta  300
tttgggaaa  ttttatgta  ggctgtgca  atcatctac  ccgtcaacc  ttacagcag  360
gttctcatc  tggccttca  cagcctgga  cgctacctt  ccattgtcc  cgccaccaa  420
agccagagc  cgaggaagc  gctggctga  aaggccgtc  atgtgggtg  ctggatccc  480
gccctcctc  tgactatcc  tgacatcat  ttcgccgat  tcagccagg  ggacggcag  540
tacatctgt  accgccttt  ccccgacag  ctgtggatg  tggtgttcc  gttccagca  600
atcatggtg  gtctcatcc  gccgggcat  gtcatcctg  cctgttact  catcatcat  660
tccaagctg  cacactcca  gggccacca  aagcgcaag  ccctcaaga  tacggtcat  720
cttatcctg  ctttctttg  ctgctggct  ccgtattac  tggggatca  catcgattc  780
ttcatcctt  tggaggtca  caagcaagg  tgtgagttc  agagcgtcg  gcacaagtg  840
atctccatc  cggaggccc  cgccttctt  cactgttgc  tgaacccca  cctctacgc  900
ttcctcggg  ccaaattca  gagctccgc  cagcatgca  tcaattcca  gagcagagg  960
tccagcctc  agatccttt  caaagggaa  cggggtgga  actcttccg  ctccacaga  1020
tcagaatcc  caagttttc  ctccagctaa  1050



<210> 9080
<211> 349
<212> PRT
<213> Rattus norvegicus
<308> O08565
<400> 9080

Met Glu Ile Tyr Thr Ser Asp Asn Tyr Ser Glu Glu Val Gly Ser Gly 
  1               5                  10                  15
Asp Tyr Asp Ser Asn Lys Glu Pro Cys Phe Arg Asp Glu Asn Glu Asn 
             20                  25                  30
Phe Asn Arg Ile Phe Leu Pro Thr Ile Tyr Phe Ile Ile Phe Leu Thr 
         35                  40                  45
Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly Tyr Gln Lys 
     50                  55                  60
Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu Ser Val Ala 
 65                  70                  75                  80
Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val Asp Ala Met 
                 85                  90                  95
Ala Asp Trp Tyr Phe Gly Lys Phe Leu Cys Lys Ala Val His Ile Ile 
             100                105                110
Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala Phe Ile Ser 
         115                120                125
Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser Gln Ser Ala 
     130                135                140
Arg Lys Leu Leu Ala Glu Lys Ala Val Tyr Val Gly Val Trp Ile Pro 
 145                150                155                160
Ala Leu Leu Leu Thr Ile Pro Asp Ile Ile Phe Ala Asp Val Ser Gln 
                 165                170                175
Gly Asp Gly Arg Tyr Ile Cys Asp Arg Leu Tyr Pro Asp Ser Leu Trp 
             180                185                190
Met Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu Ile Leu Pro 
         195                200                205
Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser Lys Leu Ser 
     210                215                220
His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr Thr Val Ile 
 225                230                235                240
Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr Val Gly Ile 
                 245                250                255
Ser Ile Asp Ser Phe Ile Leu Leu Glu Val Ile Lys Gln Gly Cys Glu 
             260                265                270
Phe Glu Ser Val Val His Lys Trp Ile Ser Ile Thr Glu Ala Leu Ala 
         275                280                285
Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe Leu Gly Ala 
     290                295                300
Lys Phe Lys Ser Ser Ala Gln His Ala Leu Asn Ser Met Ser Arg Gly 
 305                310                315                320
Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly His Ser Ser 
                 325                330                335
Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
             340                345



<210> 9081
<211> 1670
<212> DNA
<213> Homo sapiens
<308> L06797
<400> 9081

cggcacgag  caagtgacg  cgagggcct  agtgctcca  tagccaccg  atctggaga  60
ccagcggtt  ccatggagg  gatcagtat  tacacttca  ataactaca  cgaggaaat  120
ggctcaggg  actatgact  catgaagga  ccctgtttc  gtgaagaaa  tgctaattt  180
aataaaatc  tcctgccca  catctactc  atcatcttc  taactggca  tgtgggcaa  240
ggattggtc  tcctggtca  gggttacca  aagaaactg  gaagcatga  ggacaagta  300
aggctgcac  tgtcagtgg  cgacctcct  tttgtcatc  cgcttccct  ctgggcagt  360
gatgccgtg  caaactggt  ctttgggaa  ttcctatgc  aggcagtcc  tgtcatcta  420
acagtcaac  tctacagca  tgtcctcat  ctggccttc  tcagtctgg  ccgctacct  480
gccatcgtc  acgccacca  cagtcagag  ccaaggaag  tgttggctg  aaaggtggt  540
tatgttggc  tctggatcc  tgccctcct  ctgactatt  ccgacttca  ctttgccaa  600
gtcagtgag  cagatgaca  atatatctg  gaccgcttc  accccaatg  cttgtgggt  660
gttgtgttc  agtttcagc  catcatggt  ggccttatc  tgcctggta  tgtcatcct  720
tcctgctat  gcattatca  ctccaagct  tcacactcc  agggccacc  gaagcgcaa  780
gccctcaag  ccacagtca  cctcatcct  gctttcttc  cctgttggc  gccttacta  840
attgggatc  gcatcgact  cttcatcct  ctggaaatc  tcaagcaag  gtgtgagtt  900
gagaacact  tgcacaagt  gatttccat  accgaggcc  tagctttct  ccactgttg  960
ctgaacccc  tcctctatg  tttccttgg  gccaaattt  aaacctctg  ccagcacgc  1020
ctcacctct  tgagcagag  gtccagcct  aagatcctc  ccaaaggaa  gcgaggtgg  1080
cattcatct  tttccactg  gtctgagtc  tcaagtttt  actccagct  acacagatg  1140
aagagactt  tttttatac  ataaataac  tttttttaa  ttacacatt  ttcagatat  1200
aaagactga  caatattgt  cagttttta  tgcttgttg  atttttgct  ttgtgtttc  1260
ttagttttt  gtgaaggtt  aattgactt  tttatataa  ttttttttg  ttcatattg  1320
tgtgtgtct  ggcaggacc  gtggccaag  tcttagttg  tgtatgtct  gtggtagga  1380
tgtagaaaa  ggaactgaa  attccagag  gtgtagtga  tcacgtaaa  ctagaaatg  1440
tccccagct  tttatgcat  gataatctc  ccattcccg  ggaacgttt  tcctgttct  1500
aagacgtga  tttgctgta  aagatggca  ttataacca  agcccaaag  ggtatagaa  1560
tgctggttt  tcagttttc  ggagtgggt  gatttcagc  cctacagtg  acagtcttg  1620
attaagttg  taataaaag  acatgttaa  cttaaaaaa  aaaaaaaaaa  1670



<210> 9082
<211> 352
<212> PRT
<213> Homo sapiens
<308> P30991
<400> 9082

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
  1               5                  10                  15
Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
             20                  25                  30
Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
         35                  40                  45
Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
     50                  55                  60
Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
 65                  70                  75                  80
Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                 85                  90                  95
Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
             100                105                110
His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
         115                120                125
Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
     130                135                140
Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
 145                150                155                160
Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 
                 165                170                175
Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
             180                185                190
Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
         195                200                205
Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
     210                215                220
Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
 225                230                235                240
Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                 245                250                255
Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
             260                265                270
Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
         275                280                285
Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
     290                295                300
Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
 305                310                315                320
Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                 325                330                335
His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
             340                345                350



<210> 9083
<211> 4413
<212> DNA
<213> Rattus norvegicus
<308> U90725
<400> 9083

ggcgtcttg  tcctgtttc  ccacagttc  taccttatg  gcttggatt  ctcacgcta  60
taaaagagg  gcagtaaaa  ctggcaggc  gacagaggc  acctcagga  ggactttct  120
gctactgac  attttgctg  gtcttacta  gattgtgtg  ggacgtgag  tcaaccatg  180
gctccgttg  agttttgac  caagagagt  ttgctgaac  tcgaagtgg  ctggttcca  240
aacaaatca  agttgccac  ttaaattca  aagaagaaa  tgaccctcc  acctacaag  300
atgccttcc  tccactgcc  gagaaagca  cttgcttgg  aagtgccca  gaacctgct  360
gagcctgga  taacaagat  cggcccatc  aggcctctg  catcactca  gtgtttcat  420
tacccctgg  ggagagaaa  tataaggac  tgaaccagt  tggagaagg  gaacaagca  480
aaatctgcc  tgagatcat  caaaggact  gtgctcacc  ggagctctc  ctggctaaa  540
accaaggtc  ctccatcat  gtctcaggg  agctggatg  agtcatgaa  gcccggaaa  600
acattgttg  tagactaca  acacaggcc  cagccactg  tcccattcc  aaagagcac  660
accgctttg  tattggcaa  aacggagaa  aactacaag  cttagaact  aaaactgct  720
ccaaaatcc  gatcccacg  ccagatgac  ccagtaatc  gatcaagat  actggcacc  780
aagaaggna  cgagaaagc  cgccatgag  tccttctga  ctctgctga  caggacaag  840
gtgccgtaa  gaggctaga  gtggagaag  ccttccacc  cttcatcgc  gggccgtac  900
atagacttg  gggtgaaat  atgcaggaa  cagggacgc  aatcaacat  cctccaccc  960
gtgttaacc  tacagaaat  gtcttcact  gagaaaagg  acagctggc  caggctgtg  1020
ctcgtatta  gaagattta  gaggaaaag  agaagaaga  tacgaccat  gcggtagag  1080
tgaagaaat  tcaacacaa  tatgtcatc  ggccgaagg  caactcact  caagagatc  1140
tggaacgta  tggagtctc  gttgagatc  cgccctcag  cagcatctc  gagactgtg  1200
tacttagag  cgagcctga  aagctggga  aggcattga  tgaagtcta  gccaaggcc  1260
acagtttta  agtgtcctc  gtctctgcc  cttcctggc  tcaccgttt  atcattggt  1320
agaaagggc  gaacctggc  aaaatcact  accaaatgc  aaaggttca  attgagttc  1380
cagaaggtg  ggacaagat  accctggag  gccccacag  agatgtgaa  gttgcccag  1440
aacagattg  aggaatggt  aaagacctg  ttaatcgga  ggactatgt  gaaatcaac  1500
ttgaccata  attccacag  cacctcatt  ggaagagtg  agccaacat  aacagaatc  1560
aagaccagt  caaagtgtc  gtgcgcatc  cccctgaca  cgagaagag  aacctgatc  1620
gaattgagg  agacccaca  ggtgtgcaa  aggccaagc  ggagctgct  gagcttgct  1680
ctcgcatgg  aaatgagcg  accaaggat  taatcattg  gcaaagatt  catcgcaca  1740
tcattgggc  gaaaggtga  cggattcga  aaattcgtg  caaattccc  gaggtgatc  1800
tcaactttc  ggatccagc  caaaagagt  agattgttc  actcagagg  cccaagaat  1860
aggtggaga  atgtaccaa  tacatgcag  aaatggttg  agatctggt  gaaaatagc  1920
attcaattt  tgtaccgat  ttcaaacag  ttcacaaga  tatcattgg  aaaggaggt  1980
caaacatta  aaagattcg  gaagagagc  acaccaaga  tgaccttcc  gccgagaac  2040
gcaactcgg  gaccattgt  atcactggc  agcgagcca  ctgtgaagc  gcccggagc  2100
ggatcctgt  catccagaa  gatctggcc  acatagctg  ggtggaggt  tcaatccct  2160
ccaaactac  caactctct  attggcacc  agggtcgtc  gatccgctc  atcatggag  2220
aatgtggtg  cgtccatat  cactttcct  tggaaggtt  tggtagtga  actgttgtc  2280
tcaggggtc  ttcctcaga  gtggagaag  ccaagaagc  gcttctgca  ctggctgag  2340
agaagcaaa  caagagttt  actgtggat  tccgggcca  gccagaata  cacaaattc  2400
tcattggca  agggggagg  aaaatccgc  aggtgcgcg  cagtactgg  gcccgcatt  2460
tatttccgg  tgctgagga  aaggaccag  acctgataa  aatcatagg  aaggaagat  2520
ctgtccgtg  ggcacaaaa  gagctggaa  cattgatcc  gaacctgga  aatgtggtt  2580
aagactaca  gctggtgga  cccagacac  accgccatt  tgttatccg  agaggacag  2640
tattacgag  gattgctga  gaatatggc  gggtgatgg  cagcttccc  cgctctggc  2700
cacagagtg  caaagtcac  ctcaagggt  ccaaagact  tgtggaggc  gccaagaag  2760
gaattcagg  aatcattga  gatctggaa  ctcaagtaa  gctggaatg  gctataccc  2820
agaagtttc  tcgttcggt  atgggtccc  aaggttcaa  aatccagca  atcactcgg  2880
actacaatg  tcaaattaa  ttcccagac  gagaggaaa  cccagttca  agtgtagag  2940
cttccatcc  ggagaatgg  gatgaggct  gagagggca  agaggccaa  gagaccgac  3000
cgggatctc  caggaggtg  gacatcata  ttatctctg  ccggaaaga  aaatgtgag  3060
ctgccaagg  agccctgga  gcactggtt  cagtcacca  cgaggtaga  gtacccttt  3120
atcttcacc  ctacatcat  gggcagaaa  gaagtggaa  ccgcaagat  atggatgag  3180
ttgaggtga  tatacatgt  ccagccccc  aactgcagt  acacaccat  gccatcact  3240
gccttgcag  aaatttgga  agggctaag  cggggctac  ggatcgagt  aaggagctg  3300
aggctgagc  ggaagatcg  gctttaagg  gttttaagc  gagtgtcac  gtagacccc  3360
aataccatc  caaaattat  gggggaaaa  gggcagtga  cacacagat  cgattggaa  3420
atgatgtga  catccaatt  cctgataag  acgatggga  tcagcccca  gaccaaatc  3480
ccatcacag  gtatgagaa  aacactgaa  ctgcccgtg  tgctatcct  aaaattgtg  3540
gtgagcttg  gcagatggt  tctgaggat  ttcccttgg  tcaccgtgt  catgcccga  3600
tcattggtg  cagaggcaa  gccatccgg  aaatcatgg  tgagttcaa  gtggacatt  3660
gcttcccac  gagcggagc  ccagaccct  actgcgtca  tgtgacagg  ctcccggag  3720
atgtggagg  agctatcga  catatcctc  acctagaag  ggaatatct  gctgatgtg  3780
tggacagtg  ggcgctgca  gtttacatg  agcccccag  acatgaaga  tccaaggca  3840
catccaaag  ctttgtggt  cgagatgct  cctggacct  caacagcag  gagaaggct  3900
ctgatatga  cagctctga  gaaattccc  cctttgggg  tcaagtggc  cccaagacc  3960
tcccgtggg  ccccaaacg  taatgatca  aaagaaact  tccagcctg  tgcccaaac  4020
caaccacac  atggtttgt  tcaatctga  tcagcagct  gaccctcgt  aattgttga  4080
gctccccct  cccgaagtc  cgcagcaaa  cctggtggg  tggccttct  tggctgctt  4140
ccctggcct  gtcagcacc  gcaggctca  ggtctgctc  tgacgctgt  ctctgggaa  4200
gtgcacgcc  ctgcgtgaa  cactaagca  ggtaatcga  catttcgtg  tcacagact  4260
cagcttcct  gtccaccca  catgtagtc  gcattctga  tttcacagc  gagttccac  4320
gcggctagg  gttgacttc  ttgtgtcat  acctcagga  ataaatttc  ttgacttta  4380
aaaagccaa  aaaaaaaaa  aaaaaaaaa  aaa  4413



<210> 9084
<211> 1268
<212> PRT
<213> Rattus norvegicus
<308> AAD09246
<400> 9084

Met Ser Ser Val Ala Val Leu Thr Gln Glu Ser Phe Ala Glu His Arg 
  1               5                  10                  15
Ser Gly Leu Val Pro Gln Gln Ile Ile Val Ala Thr Leu Asn Ser Glu 
             20                  25                  30
Glu Glu Ser Asp Pro Pro Thr Tyr Lys Asp Ala Phe Pro Pro Leu Pro 
         35                  40                  45
Glu Lys Ala Ala Cys Leu Glu Ser Ala Gln Glu Pro Ala Gly Ala Trp 
     50                  55                  60
Ser Asn Lys Ile Arg Pro Ile Lys Ala Ser Val Ile Thr Gln Val Phe 
 65                  70                  75                  80
His Val Pro Leu Glu Glu Arg Lys Tyr Lys Asp Met Asn Gln Phe Gly 
                 85                  90                  95
Glu Gly Glu Gln Ala Lys Ile Cys Leu Glu Ile Met Gln Arg Thr Gly 
             100                105                110
Ala His Leu Glu Leu Ser Leu Ala Lys Asp Gln Gly Leu Ser Ile Met 
         115                120                125
Val Ser Gly Lys Leu Asp Ala Val Met Lys Ala Arg Lys Asp Ile Val 
     130                135                140
Ala Arg Leu Gln Thr Gln Ala Ser Ala Thr Val Pro Ile Pro Lys Glu 
 145                150                155                160
His His Arg Phe Val Ile Gly Lys Asn Gly Glu Lys Leu Gln Asp Leu 
                 165                170                175
Glu Leu Lys Thr Ala Thr Lys Ile Gln Ile Pro Arg Pro Asp Asp Pro 
             180                185                190
Ser Asn Gln Ile Lys Ile Thr Gly Thr Lys Glu Gly Ile Glu Lys Ala 
         195                200                205
Arg His Glu Val Leu Leu Ile Ser Ala Glu Gln Asp Lys Arg Ala Val 
     210                215                220
Lys Arg Leu Glu Val Glu Lys Ala Phe His Pro Phe Ile Ala Gly Pro 
 225                230                235                240
Tyr Asn Arg Leu Val Gly Glu Ile Met Gln Glu Thr Gly Thr Arg Ile 
                 245                250                255
Asn Ile Pro Pro Pro Ser Val Asn Arg Thr Glu Ile Val Phe Thr Gly 
             260                265                270
Glu Lys Glu Gln Leu Ala Gln Ala Val Ala Arg Ile Lys Lys Ile Tyr 
         275                280                285
Glu Glu Lys Lys Lys Lys Thr Thr Thr Ile Ala Val Glu Val Lys Lys 
     290                295                300
Ser Gln His Lys Tyr Val Ile Gly Pro Lys Gly Asn Ser Leu Gln Glu 
 305                310                315                320
Ile Leu Glu Arg Thr Gly Val Ser Val Glu Ile Pro Pro Ser Asp Ser 
                 325                330                335
Ile Ser Glu Thr Val Ile Leu Arg Gly Glu Pro Glu Lys Leu Gly Gln 
             340                345                350
Ala Leu Thr Glu Val Tyr Ala Lys Ala Asn Ser Phe Thr Val Ser Ser 
         355                360                365
Val Ser Ala Pro Ser Trp Leu His Arg Phe Ile Ile Gly Lys Lys Gly 
     370                375                380
Gln Asn Leu Ala Lys Ile Thr His Gln Met Pro Lys Val His Ile Glu 
 385                390                395                400
Phe Thr Glu Gly Glu Asp Lys Ile Thr Leu Glu Gly Pro Thr Glu Asp 
                 405                410                415
Val Asn Val Ala Gln Glu Gln Ile Glu Gly Met Val Lys Asp Leu Ile 
             420                425                430
Asn Arg Met Asp Tyr Val Glu Ile Asn Ile Asp His Lys Phe His Arg 
         435                440                445
His Leu Ile Gly Lys Ser Gly Ala Asn Ile Asn Arg Ile Lys Asp Gln 
     450                455                460
Tyr Lys Val Ser Val Arg Ile Pro Pro Asp Ser Glu Lys Ser Asn Leu 
 465                470                475                480
Ile Arg Ile Glu Gly Asp Pro Gln Gly Val Gln Gln Ala Lys Arg Glu 
                 485                490                495
Leu Leu Glu Leu Ala Ser Arg Met Glu Asn Glu Arg Thr Lys Asp Leu 
             500                505                510
Ile Ile Glu Gln Arg Phe His Arg Thr Ile Ile Gly Gln Lys Gly Glu 
         515                520                525
Arg Ile Arg Glu Ile Arg Asp Lys Phe Pro Glu Val Ile Ile Asn Phe 
     530                535                540
Pro Asp Pro Ala Gln Lys Ser Glu Ile Val Gln Leu Arg Gly Pro Lys 
 545                550                555                560
Asn Glu Val Glu Lys Cys Thr Lys Tyr Met Gln Lys Met Val Ala Asp 
                 565                570                575
Leu Val Glu Asn Ser Tyr Ser Ile Ser Val Pro Ile Phe Lys Gln Phe 
             580                585                590
His Lys Asn Ile Ile Gly Lys Gly Gly Ala Asn Ile Lys Lys Ile Arg 
         595                600                605
Glu Glu Ser Asn Thr Lys Ile Asp Leu Pro Ala Glu Asn Ser Asn Ser 
     610                615                620
Glu Thr Ile Val Ile Thr Gly Lys Arg Ala Asn Cys Glu Ala Ala Arg 
 625                630                635                640
Ser Arg Ile Leu Ser Ile Gln Lys Asp Leu Ala Asn Ile Ala Glu Val 
                 645                650                655
Glu Val Ser Ile Pro Ala Lys Leu His Asn Ser Leu Ile Gly Thr Lys 
             660                665                670
Gly Arg Leu Ile Arg Ser Ile Met Glu Glu Cys Gly Gly Val His Ile 
         675                680                685
His Phe Pro Val Glu Gly Ser Gly Ser Asp Thr Val Val Ile Arg Gly 
     690                695                700
Pro Ser Ser Asp Val Glu Lys Ala Lys Lys Gln Leu Leu His Leu Ala 
 705                710                715                720
Glu Glu Lys Gln Thr Lys Ser Phe Thr Val Asp Ile Arg Ala Lys Pro 
                 725                730                735
Glu Tyr His Lys Phe Leu Ile Gly Lys Gly Gly Gly Lys Ile Arg Lys 
             740                745                750
Val Arg Asp Ser Thr Gly Ala Arg Ile Ile Phe Pro Ala Ala Glu Asp 
         755                760                765
Lys Asp Gln Asp Leu Ile Thr Ile Ile Gly Lys Glu Asp Ala Val Arg 
     770                775                780
Glu Ala Gln Lys Glu Leu Glu Ala Leu Ile Gln Asn Leu Asp Asn Val 
 785                790                795                800
Val Glu Asp Tyr Met Leu Val Asp Pro Arg His His Arg His Phe Val 
                 805                810                815
Ile Arg Arg Gly Gln Val Leu Arg Glu Ile Ala Glu Glu Tyr Gly Gly 
             820                825                830
Val Met Val Ser Phe Pro Arg Ser Gly Thr Gln Ser Asp Lys Val Thr 
         835                840                845
Leu Lys Gly Ala Lys Asp Cys Val Glu Ala Ala Lys Lys Arg Ile Gln 
     850                855                860
Glu Ile Ile Glu Asp Leu Glu Ala Gln Val Thr Leu Glu Cys Ala Ile 
 865                870                875                880
Pro Gln Lys Phe His Arg Ser Val Met Gly Pro Lys Gly Ser Arg Ile 
                 885                890                895
Gln Gln Ile Thr Arg Asp Tyr Asn Val Gln Ile Lys Phe Pro Asp Arg 
             900                905                910
Glu Glu Asn Pro Val His Ser Val Glu Pro Ser Ile Gln Glu Asn Gly 
         915                920                925
Asp Glu Ala Gly Glu Gly Arg Glu Ala Lys Glu Thr Asp Pro Gly Ser 
     930                935                940
Pro Arg Arg Cys Asp Ile Ile Val Ile Ser Gly Arg Lys Glu Lys Cys 
 945                950                955                960
Glu Ala Ala Lys Glu Ala Leu Glu Ala Leu Val Pro Val Thr Ile Glu 
                 965                970                975
Val Glu Val Pro Phe Asp Leu His Arg Tyr Ile Ile Gly Gln Lys Gly 
             980                985                990
Ser Gly Ile Arg Lys Met Met Asp Glu Phe Glu Val Asn Ile His Val 
         995                1000                1005
Pro Ala Pro Glu Leu Gln Ser His Thr Ile Ala Ile Thr Gly Leu Ala 
     1010                1015                1020
Ala Asn Leu Asp Arg Ala Lys Ala Gly Leu Leu Asp Arg Val Lys Glu 
 1025                1030                1035                1040
Leu Gln Ala Glu Gln Glu Asp Arg Ala Leu Arg Ser Phe Lys Leu Ser 
                 1045                1050                1055
Val Thr Val Asp Pro Lys Tyr His Pro Lys Ile Ile Gly Gly Lys Gly 
             1060                1065                1070
Ala Val Ile Thr Gln Ile Arg Leu Glu His Asp Val Asn Ile Gln Phe 
         1075                1080                1085
Pro Asp Lys Asp Asp Gly Asn Gln Pro Gln Asp Gln Ile Thr Ile Thr 
     1090                1095                1100
Gly Tyr Glu Lys Asn Thr Glu Ala Ala Arg Asp Ala Ile Leu Lys Ile 
 1105                1110                1115                1120
Val Gly Glu Leu Glu Gln Met Val Ser Glu Asp Val Pro Leu Asp His 
                 1125                1130                1135
Arg Val His Ala Arg Ile Ile Gly Ala Arg Gly Lys Ala Ile Arg Lys 
             1140                1145                1150
Ile Met Asp Glu Phe Lys Val Asp Ile Arg Phe Pro Gln Ser Gly Ala 
         1155                1160                1165
Pro Asp Pro Asn Cys Val Thr Val Thr Gly Leu Pro Glu Asn Val Glu 
     1170                1175                1180
Glu Ala Ile Asp His Ile Leu Asn Leu Glu Glu Glu Tyr Leu Ala Asp 
 1185                1190                1195                1200
Val Val Asp Ser Glu Ala Leu Gln Val Tyr Met Lys Pro Pro Ala His 
                 1205                1210                1215
Glu Glu Ser Lys Ala Pro Ser Lys Gly Phe Val Val Arg Asp Ala Pro 
             1220                1225                1230
Trp Thr Ser Asn Ser Ser Glu Lys Ala Pro Asp Met Ser Ser Ser Glu 
         1235                1240                1245
Glu Ile Pro Thr Phe Gly Ala Gln Val Ala Pro Lys Thr Leu Pro Trp 
     1250                1255                1260
Gly Pro Lys Arg 
 1265



<210> 9085
<211> 4354
<212> DNA
<213> Homo sapiens
<308> M64098
<400> 9085

gaattcggg  ggcgagtaa  ccagcggca  gaccagcgg  cgggggcca  aacaaaagc  60
ggcaggctg  cagaggcgg  ctcaggacg  accttctgg  tactgaccg  tttgctgtg  120
ttttcccgg  ttgtgtgta  gtgtgagat  aaccatgag  tccgttgca  ttttgaccc  180
agagagttt  gctgaacac  gaagtgggc  ggttccgca  caaatcaaa  ttgccactc  240
aaattcaga  gaggagagc  accctccaa  ctacaagga  gccttccct  cacttcctg  300
gaaagctgc  tgcctggaa  gtgcccagg  acccgctgg  gcctggggg  acaagatcc  360
acccatcaa  gcttctgtc  tcactcagg  gttccatgt  cccctggag  agagaaaat  420
caaggatat  aaccagttt  gagaaggtg  acaagcaaa  atctgcctt  agatcatgc  480
gagaactgg  gctcacttg  agctgtctt  ggccaaaga  caaggcctc  ccatcatgg  540
gtcaggaaa  ctggatgct  tcatgaaag  tcggaagga  attgttgct  gactgcaga  600
tcaggcctc  gcaactgtt  ccattccca  agaacacca  cgctttgtt  ttggcaaaa  660
tggagagaa  ctgcaagac  tggagctaa  aactgcaac  aaaatccag  tcccacgcc  720
agatgaccc  agcaatcag  tcaagatca  tggcaccaa  gagggcatc  agaaagctc  780
ccatgaagt  ttactcatc  ctgccgagc  ggacaaacg  gctgtggag  ggctagaag  840
agaaaaggc  ttccacccc  tcatcgctg  gccgtataa  agactggtt  gcgagatca  900
gcaggagac  ggcacgcgc  tcaacatcc  cccacccag  gtgaaccgg  cagagattg  960
cttcactgg  gagaaggaa  agttggctc  ggctgtggc  cgcatcaag  agatttatg  1020
ggagaagaa  aagaagact  caaccattg  agtggaagt  aagaaatcc  aacacaagt  1080
tgtcattgg  cccaagggc  attcattgc  ggagatcct  gagagaact  gagtttccg  1140
tgagatccc  ccctcagac  gcatctctg  gactgtaat  cttcgaggc  aacctgaaa  1200
gttaggtca  gcgttgact  aagtctatg  caaggccaa  agcttcacc  tctcctctg  1260
cgccgcccc  tcctggctt  accgtttca  cattggcaa  aaagggcag  acctggcca  1320
aatcactca  cagatgcca  aggttcaca  cgagttcac  gagggcgaa  acaagatca  1380
cctggaggg  cctacagag  atgtcaatg  ggcccagga  cagatagaa  gcatggtca  1440
agatttgat  aaccggatg  actatgtgg  gatcaacat  gaccacaag  tccacaggc  1500
cctcattgg  aagagcggt  ccaacataa  cagaatcaa  gaccagtac  aggtgtccg  1560
gcgcatccc  cctgacagt  agaagagca  tttgatccg  atcgagggg  acccacagg  1620
cgtgcagca  gccaagcga  agctgctgg  gcttgcatc  cgcatggaa  atgagcgta  1680
caaggatct  atcattgag  aaagatttc  tcgcacaat  attgggcag  agggtgaac  1740
gatccgtga  attcgtgac  aattcccag  ggtcatcat  aactttcca  acccagcac  1800
aaaaagtga  attgtccag  tcagaggac  taagaatga  gtggaaaaa  gcacaaaat  1860
catgcagaa  atggtggca  atctggtgg  aaatagcta  tcaatttct  ttccgatct  1920
caaacagtt  cacaagaat  tcattggga  aggaggcgc  aacattaaa  agattcgtg  1980
agaaagcaa  accaaaatc  accttccag  agagaatag  aattcagag  ccattatca  2040
cacaggcaa  cgagccaac  gcgaagctg  ccggagcag  attctgtct  ttcagaaag  2100
cctggccaa  atagccgag  tagaggtct  catccctgc  aagctgcac  actccctca  2160
tggcaccaa  ggccgtctg  tccgctcca  catggagga  tgcggcggg  tccacattc  2220
ctttcccgt  gaaggttca  gaagcgaca  cgttgttat  aggggccct  cctcggatg  2280
ggagaaggc  aagaagcag  tcctgcatc  ggcggagga  aagcaaacc  agagtttca  2340
tgttgacat  cgcgccaag  cagaatacc  caaattcct  atcggcaag  ggggcggca  2400
aattcgcaa  gtgcgcgac  gcactggag  acgtgtcat  ttccctgcg  ctgaggaca  2460
ggaccagga  ctgatcacc  tcattggaa  ggaggacgc  gtccgagag  cacagaagg  2520
gctggaggc  ttgatccaa  acctggata  tgtggtgga  gactccatg  tggtggacc  2580
caagcacca  cgccacttc  tcatccgca  aggccaggt  ttgcgggag  ttgctgaag  2640
gtatggcgg  gtgatggtc  gcttcccac  ctctggcac  cagagcgac  aagtcaccc  2700
caagggcgc  aaggactgt  tggaggcag  caagaaacg  attcaggag  tcattgagg  2760
cctggaagc  caggtgaca  tagaatgtg  tatacccca  aaattccat  gatctgtca  2820
gggccccaa  ggttccaga  tccagcaga  tactcggga  ttcagtgtt  aaattaaat  2880
cccagacag  gaggagaac  cagttcaca  tacagagcc  gttgtccag  agaatgggg  2940
cgaagctgg  gaggggaga  aggctaaag  ttgtgaccc  ggctctcca  ggaggtgtg  3000
catcatcat  atctctggc  ggaaagaaa  gtgtgaggc  gccaaggaa  ctctggagg  3060
attggttcc  gtcaccatt  aagtagagg  gccctttga  cttcaccgt  acgttattg  3120
gcagaaagg  agtgggatc  gcaagatga  ggatgagtt  gaggtgaac  tacatgtcc  3180
ggcacctga  ctgcagtct  acatcatcg  catcacggg  ctcgctgca  atttggacc  3240
ggccaaggc  ggactgctg  agcgtgtga  ggagctaca  gccgagcag  aggaccggg  3300
tttaaggag  tttaagctg  gtgtcactg  agaccccaa  taccatccc  agattatcg  3360
gagaaaggg  gcagtaatt  cccaaatcc  gttggagca  gacgtgaac  tccagtttc  3420
tgataagga  gatgggaac  agccccagg  ccaaattac  atcacaggg  acgaaaaga  3480
cacagaagc  gccagggat  ctatactga  aattgtggg  gaacttgag  agatggttt  3540
tgaggacgt  ccgctggac  accgcgttc  cgcccgcat  attggtgcc  gcggcaaag  3600
cattcgcaa  atcatggac  aattcaagg  ggacattcg  ttcccacag  gcggagccc  3660
agaccccaa  tgcgtcact  tgacggggc  cccagagaa  gtggaggaa  ccatcgacc  3720
catcctcaa  ctggaggag  aatacctag  tgacgtggt  gacagtgag  cgctgcagg  3780
atacatgaa  cccccagca  acgaagagg  caaggcacc  tccagaggc  ttgtggtgc  3840
ggacgcacc  tggaccgcc  gcagcagtg  gaaggctcc  gacatgagc  gctctgagg  3900
atttcccag  tttggggct  aggtggctc  caagaccct  ccttggggc  ccaaacgat  3960
atgatcaaa  agaacagaa  cctctccag  ctgctgacc  gaacccaac  acacaatgg  4020
ttgtctcaa  ctgacccag  ggctggacc  tccgtaaat  gttgagcgc  cttcccctt  4080
ccgaggtcc  cagggagcc  agcgcctgg  tgtgtgtgc  gccgctcct  caggcctgg  4140
cgtgcccgc  caggacctg  tccactgtt  aacaataaa  caaggtcat  agcattcga  4200
ctaagataa  agactccag  tcctggtcc  cccggcatg  cagtcagca  tctggcctt  4260
atcacgaga  ctccgcagc  gtggctagg  ttccacttc  tgtgtcatg  cctcaggaa  4320
taaacgtcc  tgactttat  aaagccccg  attc  4354



<210> 9086
<211> 1268
<212> PRT
<213> Homo sapiens
<308> Q00341
<400> 9086

Met Ser Ser Val Ala Val Leu Thr Gln Glu Ser Phe Ala Glu His Arg 
  1               5                  10                  15
Ser Gly Leu Val Pro Gln Gln Ile Lys Val Ala Thr Leu Asn Ser Glu 
             20                  25                  30
Glu Glu Ser Asp Pro Pro Thr Tyr Lys Asp Ala Phe Pro Pro Leu Pro 
         35                  40                  45
Glu Lys Ala Ala Cys Leu Glu Ser Ala Gln Glu Pro Ala Gly Ala Trp 
     50                  55                  60
Gly Asn Lys Ile Arg Pro Ile Lys Ala Ser Val Ile Thr Gln Val Phe 
 65                  70                  75                  80
His Val Pro Leu Glu Glu Arg Lys Tyr Lys Asp Met Asn Gln Phe Gly 
                 85                  90                  95
Glu Gly Glu Gln Ala Lys Ile Cys Leu Glu Ile Met Gln Arg Thr Gly 
             100                105                110
Ala His Leu Glu Leu Ser Leu Ala Lys Asp Gln Gly Leu Ser Ile Met 
         115                120                125
Val Ser Gly Lys Leu Asp Ala Val Met Lys Ala Arg Lys Asp Ile Val 
     130                135                140
Ala Arg Leu Gln Thr Gln Ala Ser Ala Thr Val Ala Ile Pro Lys Glu 
 145                150                155                160
His His Arg Phe Val Ile Gly Lys Asn Gly Glu Lys Leu Gln Asp Leu 
                 165                170                175
Glu Leu Lys Thr Ala Thr Lys Ile Gln Ile Pro Arg Pro Asp Asp Pro 
             180                185                190
Ser Asn Gln Ile Lys Ile Thr Gly Thr Lys Glu Gly Ile Glu Lys Ala 
         195                200                205
Arg His Glu Val Leu Leu Ile Ser Ala Glu Gln Asp Lys Arg Ala Val 
     210                215                220
Glu Arg Leu Glu Val Glu Lys Ala Phe His Pro Phe Ile Ala Gly Pro 
 225                230                235                240
Tyr Asn Arg Leu Val Gly Glu Ile Met Gln Glu Thr Gly Thr Arg Ile 
                 245                250                255
Asn Ile Pro Pro Pro Ser Val Asn Arg Thr Glu Ile Val Phe Thr Gly 
             260                265                270
Glu Lys Glu Gln Leu Ala Gln Ala Val Ala Arg Ile Lys Lys Ile Tyr 
         275                280                285
Glu Glu Lys Lys Lys Lys Thr Thr Thr Ile Ala Val Glu Val Lys Lys 
     290                295                300
Ser Gln His Lys Tyr Val Ile Gly Pro Lys Gly Asn Ser Leu Gln Glu 
 305                310                315                320
Ile Leu Glu Arg Thr Gly Val Ser Val Glu Ile Pro Pro Ser Asp Ser 
                 325                330                335
Ile Ser Glu Thr Val Ile Leu Arg Gly Glu Pro Glu Lys Leu Gly Gln 
             340                345                350
Ala Leu Thr Glu Val Tyr Ala Lys Ala Asn Ser Phe Thr Val Ser Ser 
         355                360                365
Val Ala Ala Pro Ser Trp Leu His Arg Phe Ile Ile Gly Lys Lys Gly 
     370                375                380
Gln Asn Leu Ala Lys Ile Thr Gln Gln Met Pro Lys Val His Ile Glu 
 385                390                395                400
Phe Thr Glu Gly Glu Asp Lys Ile Thr Leu Glu Gly Pro Thr Glu Asp 
                 405                410                415
Val Asn Val Ala Gln Glu Gln Ile Glu Gly Met Val Lys Asp Leu Ile 
             420                425                430
Asn Arg Met Asp Tyr Val Glu Ile Asn Ile Asp His Lys Phe His Arg 
         435                440                445
His Leu Ile Gly Lys Ser Gly Ala Asn Ile Asn Arg Ile Lys Asp Gln 
     450                455                460
Tyr Lys Val Ser Val Arg Ile Pro Pro Asp Ser Glu Lys Ser Asn Leu 
 465                470                475                480
Ile Arg Ile Glu Gly Asp Pro Gln Gly Val Gln Gln Ala Lys Arg Glu 
                 485                490                495
Leu Leu Glu Leu Ala Ser Arg Met Glu Asn Glu Arg Thr Lys Asp Leu 
             500                505                510
Ile Ile Glu Gln Arg Phe His Arg Thr Ile Ile Gly Gln Lys Gly Glu 
         515                520                525
Arg Ile Arg Glu Ile Arg Asp Lys Phe Pro Glu Val Ile Ile Asn Phe 
     530                535                540
Pro Asp Pro Ala Gln Lys Ser Asp Ile Val Gln Leu Arg Gly Pro Lys 
 545                550                555                560
Asn Glu Val Glu Lys Cys Thr Lys Tyr Met Gln Lys Met Val Ala Asp 
                 565                570                575
Leu Val Glu Asn Ser Tyr Ser Ile Ser Val Pro Ile Phe Lys Gln Phe 
             580                585                590
His Lys Asn Ile Ile Gly Lys Gly Gly Ala Asn Ile Lys Lys Ile Arg 
         595                600                605
Glu Glu Ser Asn Thr Lys Ile Asp Leu Pro Ala Glu Asn Ser Asn Ser 
     610                615                620
Glu Thr Ile Ile Ile Thr Gly Lys Arg Ala Asn Cys Glu Ala Ala Arg 
 625                630                635                640
Ser Arg Ile Leu Ser Ile Gln Lys Asp Leu Ala Asn Ile Ala Glu Val 
                 645                650                655
Glu Val Ser Ile Pro Ala Lys Leu His Asn Ser Leu Ile Gly Thr Lys 
             660                665                670
Gly Arg Leu Ile Arg Ser Ile Met Glu Glu Cys Gly Gly Val His Ile 
         675                680                685
His Phe Pro Val Glu Gly Ser Gly Ser Asp Thr Val Val Ile Arg Gly 
     690                695                700
Pro Ser Ser Asp Val Glu Lys Ala Lys Lys Gln Leu Leu His Leu Ala 
 705                710                715                720
Glu Glu Lys Gln Thr Lys Ser Phe Thr Val Asp Ile Arg Ala Lys Pro 
                 725                730                735
Glu Tyr His Lys Phe Leu Ile Gly Lys Gly Gly Gly Lys Ile Arg Lys 
             740                745                750
Val Arg Asp Ser Thr Gly Ala Arg Val Ile Phe Pro Ala Ala Glu Asp 
         755                760                765
Lys Asp Gln Asp Leu Ile Thr Ile Ile Gly Lys Glu Asp Ala Val Arg 
     770                775                780
Glu Ala Gln Lys Glu Leu Glu Ala Leu Ile Gln Asn Leu Asp Asn Val 
 785                790                795                800
Val Glu Asp Ser Met Leu Val Asp Pro Lys His His Arg His Phe Val 
                 805                810                815
Ile Arg Arg Gly Gln Val Leu Arg Glu Ile Ala Glu Glu Tyr Gly Gly 
             820                825                830
Val Met Val Ser Phe Pro Arg Ser Gly Thr Gln Ser Asp Lys Val Thr 
         835                840                845
Leu Lys Gly Ala Lys Asp Cys Val Glu Ala Ala Lys Lys Arg Ile Gln 
     850                855                860
Glu Ile Ile Glu Asp Leu Glu Ala Gln Val Thr Leu Glu Cys Ala Ile 
 865                870                875                880
Pro Gln Lys Phe His Arg Ser Val Met Gly Pro Lys Gly Ser Arg Ile 
                 885                890                895
Gln Gln Ile Thr Arg Asp Phe Ser Val Gln Ile Lys Phe Pro Asp Arg 
             900                905                910
Glu Glu Asn Ala Val His Ser Thr Glu Pro Val Val Gln Glu Asn Gly 
         915                920                925
Asp Glu Ala Gly Glu Gly Arg Glu Ala Lys Asp Cys Asp Pro Gly Ser 
     930                935                940
Pro Arg Arg Cys Asp Ile Ile Ile Ile Ser Gly Arg Lys Glu Lys Cys 
 945                950                955                960
Glu Ala Ala Lys Glu Ala Leu Glu Ala Leu Val Pro Val Thr Ile Glu 
                 965                970                975
Val Glu Val Pro Phe Asp Leu His Arg Tyr Val Ile Gly Gln Lys Gly 
             980                985                990
Ser Gly Ile Arg Lys Met Met Asp Glu Phe Glu Val Asn Ile His Val 
         995                1000                1005
Pro Ala Pro Glu Leu Gln Ser Asp Ile Ile Ala Ile Thr Gly Leu Ala 
     1010                1015                1020
Ala Asn Leu Asp Arg Ala Lys Ala Gly Leu Leu Glu Arg Val Lys Glu 
 1025                1030                1035                1040
Leu Gln Ala Glu Gln Glu Asp Arg Ala Leu Arg Ser Phe Lys Leu Ser 
                 1045                1050                1055
Val Thr Val Asp Pro Lys Tyr His Pro Lys Ile Ile Gly Arg Lys Gly 
             1060                1065                1070
Ala Val Ile Thr Gln Ile Arg Leu Glu His Asp Val Asn Ile Gln Phe 
         1075                1080                1085
Pro Asp Lys Asp Asp Gly Asn Gln Pro Gln Asp Gln Ile Thr Ile Thr 
     1090                1095                1100
Gly Tyr Glu Lys Asn Thr Glu Ala Ala Arg Asp Ala Ile Leu Arg Ile 
 1105                1110                1115                1120
Val Gly Glu Leu Glu Gln Met Val Ser Glu Asp Val Pro Leu Asp His 
                 1125                1130                1135
Arg Val His Ala Arg Ile Ile Gly Ala Arg Gly Lys Ala Ile Arg Lys 
             1140                1145                1150
Ile Met Asp Glu Phe Lys Val Asp Ile Arg Phe Pro Gln Ser Gly Ala 
         1155                1160                1165
Pro Asp Pro Asn Cys Val Thr Val Thr Gly Leu Pro Glu Asn Val Glu 
     1170                1175                1180
Glu Ala Ile Asp His Ile Leu Asn Leu Glu Glu Glu Tyr Leu Ala Asp 
 1185                1190                1195                1200
Val Val Asp Ser Glu Ala Leu Gln Val Tyr Met Lys Pro Pro Ala His 
                 1205                1210                1215
Glu Glu Ala Lys Ala Pro Ser Arg Gly Phe Val Val Arg Asp Ala Pro 
             1220                1225                1230
Trp Thr Ala Ser Ser Ser Glu Lys Ala Pro Asp Met Ser Ser Ser Glu 
         1235                1240                1245
Glu Phe Pro Ser Phe Gly Ala Gln Val Ala Pro Lys Thr Leu Pro Trp 
     1250                1255                1260
Gly Pro Lys Arg 
 1265



<210> 9087
<211> 4413
<212> DNA
<213> Rattus norvegicus
<308> U90725
<400> 9087

ggcgtcttg  tcctgtttc  ccacagttc  taccttatg  gcttggatt  ctcacgcta  60
taaaagagg  gcagtaaaa  ctggcaggc  gacagaggc  acctcagga  ggactttct  120
gctactgac  attttgctg  gtcttacta  gattgtgtg  ggacgtgag  tcaaccatg  180
gctccgttg  agttttgac  caagagagt  ttgctgaac  tcgaagtgg  ctggttcca  240
aacaaatca  agttgccac  ttaaattca  aagaagaaa  tgaccctcc  acctacaag  300
atgccttcc  tccactgcc  gagaaagca  cttgcttgg  aagtgccca  gaacctgct  360
gagcctgga  taacaagat  cggcccatc  aggcctctg  catcactca  gtgtttcat  420
tacccctgg  ggagagaaa  tataaggac  tgaaccagt  tggagaagg  gaacaagca  480
aaatctgcc  tgagatcat  caaaggact  gtgctcacc  ggagctctc  ctggctaaa  540
accaaggtc  ctccatcat  gtctcaggg  agctggatg  agtcatgaa  gcccggaaa  600
acattgttg  tagactaca  acacaggcc  cagccactg  tcccattcc  aaagagcac  660
accgctttg  tattggcaa  aacggagaa  aactacaag  cttagaact  aaaactgct  720
ccaaaatcc  gatcccacg  ccagatgac  ccagtaatc  gatcaagat  actggcacc  780
aagaaggna  cgagaaagc  cgccatgag  tccttctga  ctctgctga  caggacaag  840
gtgccgtaa  gaggctaga  gtggagaag  ccttccacc  cttcatcgc  gggccgtac  900
atagacttg  gggtgaaat  atgcaggaa  cagggacgc  aatcaacat  cctccaccc  960
gtgttaacc  tacagaaat  gtcttcact  gagaaaagg  acagctggc  caggctgtg  1020
ctcgtatta  gaagattta  gaggaaaag  agaagaaga  tacgaccat  gcggtagag  1080
tgaagaaat  tcaacacaa  tatgtcatc  ggccgaagg  caactcact  caagagatc  1140
tggaacgta  tggagtctc  gttgagatc  cgccctcag  cagcatctc  gagactgtg  1200
tacttagag  cgagcctga  aagctggga  aggcattga  tgaagtcta  gccaaggcc  1260
acagtttta  agtgtcctc  gtctctgcc  cttcctggc  tcaccgttt  atcattggt  1320
agaaagggc  gaacctggc  aaaatcact  accaaatgc  aaaggttca  attgagttc  1380
cagaaggtg  ggacaagat  accctggag  gccccacag  agatgtgaa  gttgcccag  1440
aacagattg  aggaatggt  aaagacctg  ttaatcgga  ggactatgt  gaaatcaac  1500
ttgaccata  attccacag  cacctcatt  ggaagagtg  agccaacat  aacagaatc  1560
aagaccagt  caaagtgtc  gtgcgcatc  cccctgaca  cgagaagag  aacctgatc  1620
gaattgagg  agacccaca  ggtgtgcaa  aggccaagc  ggagctgct  gagcttgct  1680
ctcgcatgg  aaatgagcg  accaaggat  taatcattg  gcaaagatt  catcgcaca  1740
tcattgggc  gaaaggtga  cggattcga  aaattcgtg  caaattccc  gaggtgatc  1800
tcaactttc  ggatccagc  caaaagagt  agattgttc  actcagagg  cccaagaat  1860
aggtggaga  atgtaccaa  tacatgcag  aaatggttg  agatctggt  gaaaatagc  1920
attcaattt  tgtaccgat  ttcaaacag  ttcacaaga  tatcattgg  aaaggaggt  1980
caaacatta  aaagattcg  gaagagagc  acaccaaga  tgaccttcc  gccgagaac  2040
gcaactcgg  gaccattgt  atcactggc  agcgagcca  ctgtgaagc  gcccggagc  2100
ggatcctgt  catccagaa  gatctggcc  acatagctg  ggtggaggt  tcaatccct  2160
ccaaactac  caactctct  attggcacc  agggtcgtc  gatccgctc  atcatggag  2220
aatgtggtg  cgtccatat  cactttcct  tggaaggtt  tggtagtga  actgttgtc  2280
tcaggggtc  ttcctcaga  gtggagaag  ccaagaagc  gcttctgca  ctggctgag  2340
agaagcaaa  caagagttt  actgtggat  tccgggcca  gccagaata  cacaaattc  2400
tcattggca  agggggagg  aaaatccgc  aggtgcgcg  cagtactgg  gcccgcatt  2460
tatttccgg  tgctgagga  aaggaccag  acctgataa  aatcatagg  aaggaagat  2520
ctgtccgtg  ggcacaaaa  gagctggaa  cattgatcc  gaacctgga  aatgtggtt  2580
aagactaca  gctggtgga  cccagacac  accgccatt  tgttatccg  agaggacag  2640
tattacgag  gattgctga  gaatatggc  gggtgatgg  cagcttccc  cgctctggc  2700
cacagagtg  caaagtcac  ctcaagggt  ccaaagact  tgtggaggc  gccaagaag  2760
gaattcagg  aatcattga  gatctggaa  ctcaagtaa  gctggaatg  gctataccc  2820
agaagtttc  tcgttcggt  atgggtccc  aaggttcaa  aatccagca  atcactcgg  2880
actacaatg  tcaaattaa  ttcccagac  gagaggaaa  cccagttca  agtgtagag  2940
cttccatcc  ggagaatgg  gatgaggct  gagagggca  agaggccaa  gagaccgac  3000
cgggatctc  caggaggtg  gacatcata  ttatctctg  ccggaaaga  aaatgtgag  3060
ctgccaagg  agccctgga  gcactggtt  cagtcacca  cgaggtaga  gtacccttt  3120
atcttcacc  ctacatcat  gggcagaaa  gaagtggaa  ccgcaagat  atggatgag  3180
ttgaggtga  tatacatgt  ccagccccc  aactgcagt  acacaccat  gccatcact  3240
gccttgcag  aaatttgga  agggctaag  cggggctac  ggatcgagt  aaggagctg  3300
aggctgagc  ggaagatcg  gctttaagg  gttttaagc  gagtgtcac  gtagacccc  3360
aataccatc  caaaattat  gggggaaaa  gggcagtga  cacacagat  cgattggaa  3420
atgatgtga  catccaatt  cctgataag  acgatggga  tcagcccca  gaccaaatc  3480
ccatcacag  gtatgagaa  aacactgaa  ctgcccgtg  tgctatcct  aaaattgtg  3540
gtgagcttg  gcagatggt  tctgaggat  ttcccttgg  tcaccgtgt  catgcccga  3600
tcattggtg  cagaggcaa  gccatccgg  aaatcatgg  tgagttcaa  gtggacatt  3660
gcttcccac  gagcggagc  ccagaccct  actgcgtca  tgtgacagg  ctcccggag  3720
atgtggagg  agctatcga  catatcctc  acctagaag  ggaatatct  gctgatgtg  3780
tggacagtg  ggcgctgca  gtttacatg  agcccccag  acatgaaga  tccaaggca  3840
catccaaag  ctttgtggt  cgagatgct  cctggacct  caacagcag  gagaaggct  3900
ctgatatga  cagctctga  gaaattccc  cctttgggg  tcaagtggc  cccaagacc  3960
tcccgtggg  ccccaaacg  taatgatca  aaagaaact  tccagcctg  tgcccaaac  4020
caaccacac  atggtttgt  tcaatctga  tcagcagct  gaccctcgt  aattgttga  4080
gctccccct  cccgaagtc  cgcagcaaa  cctggtggg  tggccttct  tggctgctt  4140
ccctggcct  gtcagcacc  gcaggctca  ggtctgctc  tgacgctgt  ctctgggaa  4200
gtgcacgcc  ctgcgtgaa  cactaagca  ggtaatcga  catttcgtg  tcacagact  4260
cagcttcct  gtccaccca  catgtagtc  gcattctga  tttcacagc  gagttccac  4320
gcggctagg  gttgacttc  ttgtgtcat  acctcagga  ataaatttc  ttgacttta  4380
aaaagccaa  aaaaaaaaa  aaaaaaaaa  aaa  4413



<210> 9088
<211> 1268
<212> PRT
<213> Rattus norvegicus
<308> AAD09246
<400> 9088

Met Ser Ser Val Ala Val Leu Thr Gln Glu Ser Phe Ala Glu His Arg 
  1               5                  10                  15
Ser Gly Leu Val Pro Gln Gln Ile Ile Val Ala Thr Leu Asn Ser Glu 
             20                  25                  30
Glu Glu Ser Asp Pro Pro Thr Tyr Lys Asp Ala Phe Pro Pro Leu Pro 
         35                  40                  45
Glu Lys Ala Ala Cys Leu Glu Ser Ala Gln Glu Pro Ala Gly Ala Trp 
     50                  55                  60
Ser Asn Lys Ile Arg Pro Ile Lys Ala Ser Val Ile Thr Gln Val Phe 
 65                  70                  75                  80
His Val Pro Leu Glu Glu Arg Lys Tyr Lys Asp Met Asn Gln Phe Gly 
                 85                  90                  95
Glu Gly Glu Gln Ala Lys Ile Cys Leu Glu Ile Met Gln Arg Thr Gly 
             100                105                110
Ala His Leu Glu Leu Ser Leu Ala Lys Asp Gln Gly Leu Ser Ile Met 
         115                120                125
Val Ser Gly Lys Leu Asp Ala Val Met Lys Ala Arg Lys Asp Ile Val 
     130                135                140
Ala Arg Leu Gln Thr Gln Ala Ser Ala Thr Val Pro Ile Pro Lys Glu 
 145                150                155                160
His His Arg Phe Val Ile Gly Lys Asn Gly Glu Lys Leu Gln Asp Leu 
                 165                170                175
Glu Leu Lys Thr Ala Thr Lys Ile Gln Ile Pro Arg Pro Asp Asp Pro 
             180                185                190
Ser Asn Gln Ile Lys Ile Thr Gly Thr Lys Glu Gly Ile Glu Lys Ala 
         195                200                205
Arg His Glu Val Leu Leu Ile Ser Ala Glu Gln Asp Lys Arg Ala Val 
     210                215                220
Lys Arg Leu Glu Val Glu Lys Ala Phe His Pro Phe Ile Ala Gly Pro 
 225                230                235                240
Tyr Asn Arg Leu Val Gly Glu Ile Met Gln Glu Thr Gly Thr Arg Ile 
                 245                250                255
Asn Ile Pro Pro Pro Ser Val Asn Arg Thr Glu Ile Val Phe Thr Gly 
             260                265                270
Glu Lys Glu Gln Leu Ala Gln Ala Val Ala Arg Ile Lys Lys Ile Tyr 
         275                280                285
Glu Glu Lys Lys Lys Lys Thr Thr Thr Ile Ala Val Glu Val Lys Lys 
     290                295                300
Ser Gln His Lys Tyr Val Ile Gly Pro Lys Gly Asn Ser Leu Gln Glu 
 305                310                315                320
Ile Leu Glu Arg Thr Gly Val Ser Val Glu Ile Pro Pro Ser Asp Ser 
                 325                330                335
Ile Ser Glu Thr Val Ile Leu Arg Gly Glu Pro Glu Lys Leu Gly Gln 
             340                345                350
Ala Leu Thr Glu Val Tyr Ala Lys Ala Asn Ser Phe Thr Val Ser Ser 
         355                360                365
Val Ser Ala Pro Ser Trp Leu His Arg Phe Ile Ile Gly Lys Lys Gly 
     370                375                380
Gln Asn Leu Ala Lys Ile Thr His Gln Met Pro Lys Val His Ile Glu 
 385                390                395                400
Phe Thr Glu Gly Glu Asp Lys Ile Thr Leu Glu Gly Pro Thr Glu Asp 
                 405                410                415
Val Asn Val Ala Gln Glu Gln Ile Glu Gly Met Val Lys Asp Leu Ile 
             420                425                430
Asn Arg Met Asp Tyr Val Glu Ile Asn Ile Asp His Lys Phe His Arg 
         435                440                445
His Leu Ile Gly Lys Ser Gly Ala Asn Ile Asn Arg Ile Lys Asp Gln 
     450                455                460
Tyr Lys Val Ser Val Arg Ile Pro Pro Asp Ser Glu Lys Ser Asn Leu 
 465                470                475                480
Ile Arg Ile Glu Gly Asp Pro Gln Gly Val Gln Gln Ala Lys Arg Glu 
                 485                490                495
Leu Leu Glu Leu Ala Ser Arg Met Glu Asn Glu Arg Thr Lys Asp Leu 
             500                505                510
Ile Ile Glu Gln Arg Phe His Arg Thr Ile Ile Gly Gln Lys Gly Glu 
         515                520                525
Arg Ile Arg Glu Ile Arg Asp Lys Phe Pro Glu Val Ile Ile Asn Phe 
     530                535                540
Pro Asp Pro Ala Gln Lys Ser Glu Ile Val Gln Leu Arg Gly Pro Lys 
 545                550                555                560
Asn Glu Val Glu Lys Cys Thr Lys Tyr Met Gln Lys Met Val Ala Asp 
                 565                570                575
Leu Val Glu Asn Ser Tyr Ser Ile Ser Val Pro Ile Phe Lys Gln Phe 
             580                585                590
His Lys Asn Ile Ile Gly Lys Gly Gly Ala Asn Ile Lys Lys Ile Arg 
         595                600                605
Glu Glu Ser Asn Thr Lys Ile Asp Leu Pro Ala Glu Asn Ser Asn Ser 
     610                615                620
Glu Thr Ile Val Ile Thr Gly Lys Arg Ala Asn Cys Glu Ala Ala Arg 
 625                630                635                640
Ser Arg Ile Leu Ser Ile Gln Lys Asp Leu Ala Asn Ile Ala Glu Val 
                 645                650                655
Glu Val Ser Ile Pro Ala Lys Leu His Asn Ser Leu Ile Gly Thr Lys 
             660                665                670
Gly Arg Leu Ile Arg Ser Ile Met Glu Glu Cys Gly Gly Val His Ile 
         675                680                685
His Phe Pro Val Glu Gly Ser Gly Ser Asp Thr Val Val Ile Arg Gly 
     690                695                700
Pro Ser Ser Asp Val Glu Lys Ala Lys Lys Gln Leu Leu His Leu Ala 
 705                710                715                720
Glu Glu Lys Gln Thr Lys Ser Phe Thr Val Asp Ile Arg Ala Lys Pro 
                 725                730                735
Glu Tyr His Lys Phe Leu Ile Gly Lys Gly Gly Gly Lys Ile Arg Lys 
             740                745                750
Val Arg Asp Ser Thr Gly Ala Arg Ile Ile Phe Pro Ala Ala Glu Asp 
         755                760                765
Lys Asp Gln Asp Leu Ile Thr Ile Ile Gly Lys Glu Asp Ala Val Arg 
     770                775                780
Glu Ala Gln Lys Glu Leu Glu Ala Leu Ile Gln Asn Leu Asp Asn Val 
 785                790                795                800
Val Glu Asp Tyr Met Leu Val Asp Pro Arg His His Arg His Phe Val 
                 805                810                815
Ile Arg Arg Gly Gln Val Leu Arg Glu Ile Ala Glu Glu Tyr Gly Gly 
             820                825                830
Val Met Val Ser Phe Pro Arg Ser Gly Thr Gln Ser Asp Lys Val Thr 
         835                840                845
Leu Lys Gly Ala Lys Asp Cys Val Glu Ala Ala Lys Lys Arg Ile Gln 
     850                855                860
Glu Ile Ile Glu Asp Leu Glu Ala Gln Val Thr Leu Glu Cys Ala Ile 
 865                870                875                880
Pro Gln Lys Phe His Arg Ser Val Met Gly Pro Lys Gly Ser Arg Ile 
                 885                890                895
Gln Gln Ile Thr Arg Asp Tyr Asn Val Gln Ile Lys Phe Pro Asp Arg 
             900                905                910
Glu Glu Asn Pro Val His Ser Val Glu Pro Ser Ile Gln Glu Asn Gly 
         915                920                925
Asp Glu Ala Gly Glu Gly Arg Glu Ala Lys Glu Thr Asp Pro Gly Ser 
     930                935                940
Pro Arg Arg Cys Asp Ile Ile Val Ile Ser Gly Arg Lys Glu Lys Cys 
 945                950                955                960
Glu Ala Ala Lys Glu Ala Leu Glu Ala Leu Val Pro Val Thr Ile Glu 
                 965                970                975
Val Glu Val Pro Phe Asp Leu His Arg Tyr Ile Ile Gly Gln Lys Gly 
             980                985                990
Ser Gly Ile Arg Lys Met Met Asp Glu Phe Glu Val Asn Ile His Val 
         995                1000                1005
Pro Ala Pro Glu Leu Gln Ser His Thr Ile Ala Ile Thr Gly Leu Ala 
     1010                1015                1020
Ala Asn Leu Asp Arg Ala Lys Ala Gly Leu Leu Asp Arg Val Lys Glu 
 1025                1030                1035                1040
Leu Gln Ala Glu Gln Glu Asp Arg Ala Leu Arg Ser Phe Lys Leu Ser 
                 1045                1050                1055
Val Thr Val Asp Pro Lys Tyr His Pro Lys Ile Ile Gly Gly Lys Gly 
             1060                1065                1070
Ala Val Ile Thr Gln Ile Arg Leu Glu His Asp Val Asn Ile Gln Phe 
         1075                1080                1085
Pro Asp Lys Asp Asp Gly Asn Gln Pro Gln Asp Gln Ile Thr Ile Thr 
     1090                1095                1100
Gly Tyr Glu Lys Asn Thr Glu Ala Ala Arg Asp Ala Ile Leu Lys Ile 
 1105                1110                1115                1120
Val Gly Glu Leu Glu Gln Met Val Ser Glu Asp Val Pro Leu Asp His 
                 1125                1130                1135
Arg Val His Ala Arg Ile Ile Gly Ala Arg Gly Lys Ala Ile Arg Lys 
             1140                1145                1150
Ile Met Asp Glu Phe Lys Val Asp Ile Arg Phe Pro Gln Ser Gly Ala 
         1155                1160                1165
Pro Asp Pro Asn Cys Val Thr Val Thr Gly Leu Pro Glu Asn Val Glu 
     1170                1175                1180
Glu Ala Ile Asp His Ile Leu Asn Leu Glu Glu Glu Tyr Leu Ala Asp 
 1185                1190                1195                1200
Val Val Asp Ser Glu Ala Leu Gln Val Tyr Met Lys Pro Pro Ala His 
                 1205                1210                1215
Glu Glu Ser Lys Ala Pro Ser Lys Gly Phe Val Val Arg Asp Ala Pro 
             1220                1225                1230
Trp Thr Ser Asn Ser Ser Glu Lys Ala Pro Asp Met Ser Ser Ser Glu 
         1235                1240                1245
Glu Ile Pro Thr Phe Gly Ala Gln Val Ala Pro Lys Thr Leu Pro Trp 
     1250                1255                1260
Gly Pro Lys Arg 
 1265



<210> 9089
<211> 4354
<212> DNA
<213> Homo sapiens
<308> M64098
<400> 9089

gaattcggg  ggcgagtaa  ccagcggca  gaccagcgg  cgggggcca  aacaaaagc  60
ggcaggctg  cagaggcgg  ctcaggacg  accttctgg  tactgaccg  tttgctgtg  120
ttttcccgg  ttgtgtgta  gtgtgagat  aaccatgag  tccgttgca  ttttgaccc  180
agagagttt  gctgaacac  gaagtgggc  ggttccgca  caaatcaaa  ttgccactc  240
aaattcaga  gaggagagc  accctccaa  ctacaagga  gccttccct  cacttcctg  300
gaaagctgc  tgcctggaa  gtgcccagg  acccgctgg  gcctggggg  acaagatcc  360
acccatcaa  gcttctgtc  tcactcagg  gttccatgt  cccctggag  agagaaaat  420
caaggatat  aaccagttt  gagaaggtg  acaagcaaa  atctgcctt  agatcatgc  480
gagaactgg  gctcacttg  agctgtctt  ggccaaaga  caaggcctc  ccatcatgg  540
gtcaggaaa  ctggatgct  tcatgaaag  tcggaagga  attgttgct  gactgcaga  600
tcaggcctc  gcaactgtt  ccattccca  agaacacca  cgctttgtt  ttggcaaaa  660
tggagagaa  ctgcaagac  tggagctaa  aactgcaac  aaaatccag  tcccacgcc  720
agatgaccc  agcaatcag  tcaagatca  tggcaccaa  gagggcatc  agaaagctc  780
ccatgaagt  ttactcatc  ctgccgagc  ggacaaacg  gctgtggag  ggctagaag  840
agaaaaggc  ttccacccc  tcatcgctg  gccgtataa  agactggtt  gcgagatca  900
gcaggagac  ggcacgcgc  tcaacatcc  cccacccag  gtgaaccgg  cagagattg  960
cttcactgg  gagaaggaa  agttggctc  ggctgtggc  cgcatcaag  agatttatg  1020
ggagaagaa  aagaagact  caaccattg  agtggaagt  aagaaatcc  aacacaagt  1080
tgtcattgg  cccaagggc  attcattgc  ggagatcct  gagagaact  gagtttccg  1140
tgagatccc  ccctcagac  gcatctctg  gactgtaat  cttcgaggc  aacctgaaa  1200
gttaggtca  gcgttgact  aagtctatg  caaggccaa  agcttcacc  tctcctctg  1260
cgccgcccc  tcctggctt  accgtttca  cattggcaa  aaagggcag  acctggcca  1320
aatcactca  cagatgcca  aggttcaca  cgagttcac  gagggcgaa  acaagatca  1380
cctggaggg  cctacagag  atgtcaatg  ggcccagga  cagatagaa  gcatggtca  1440
agatttgat  aaccggatg  actatgtgg  gatcaacat  gaccacaag  tccacaggc  1500
cctcattgg  aagagcggt  ccaacataa  cagaatcaa  gaccagtac  aggtgtccg  1560
gcgcatccc  cctgacagt  agaagagca  tttgatccg  atcgagggg  acccacagg  1620
cgtgcagca  gccaagcga  agctgctgg  gcttgcatc  cgcatggaa  atgagcgta  1680
caaggatct  atcattgag  aaagatttc  tcgcacaat  attgggcag  agggtgaac  1740
gatccgtga  attcgtgac  aattcccag  ggtcatcat  aactttcca  acccagcac  1800
aaaaagtga  attgtccag  tcagaggac  taagaatga  gtggaaaaa  gcacaaaat  1860
catgcagaa  atggtggca  atctggtgg  aaatagcta  tcaatttct  ttccgatct  1920
caaacagtt  cacaagaat  tcattggga  aggaggcgc  aacattaaa  agattcgtg  1980
agaaagcaa  accaaaatc  accttccag  agagaatag  aattcagag  ccattatca  2040
cacaggcaa  cgagccaac  gcgaagctg  ccggagcag  attctgtct  ttcagaaag  2100
cctggccaa  atagccgag  tagaggtct  catccctgc  aagctgcac  actccctca  2160
tggcaccaa  ggccgtctg  tccgctcca  catggagga  tgcggcggg  tccacattc  2220
ctttcccgt  gaaggttca  gaagcgaca  cgttgttat  aggggccct  cctcggatg  2280
ggagaaggc  aagaagcag  tcctgcatc  ggcggagga  aagcaaacc  agagtttca  2340
tgttgacat  cgcgccaag  cagaatacc  caaattcct  atcggcaag  ggggcggca  2400
aattcgcaa  gtgcgcgac  gcactggag  acgtgtcat  ttccctgcg  ctgaggaca  2460
ggaccagga  ctgatcacc  tcattggaa  ggaggacgc  gtccgagag  cacagaagg  2520
gctggaggc  ttgatccaa  acctggata  tgtggtgga  gactccatg  tggtggacc  2580
caagcacca  cgccacttc  tcatccgca  aggccaggt  ttgcgggag  ttgctgaag  2640
gtatggcgg  gtgatggtc  gcttcccac  ctctggcac  cagagcgac  aagtcaccc  2700
caagggcgc  aaggactgt  tggaggcag  caagaaacg  attcaggag  tcattgagg  2760
cctggaagc  caggtgaca  tagaatgtg  tatacccca  aaattccat  gatctgtca  2820
gggccccaa  ggttccaga  tccagcaga  tactcggga  ttcagtgtt  aaattaaat  2880
cccagacag  gaggagaac  cagttcaca  tacagagcc  gttgtccag  agaatgggg  2940
cgaagctgg  gaggggaga  aggctaaag  ttgtgaccc  ggctctcca  ggaggtgtg  3000
catcatcat  atctctggc  ggaaagaaa  gtgtgaggc  gccaaggaa  ctctggagg  3060
attggttcc  gtcaccatt  aagtagagg  gccctttga  cttcaccgt  acgttattg  3120
gcagaaagg  agtgggatc  gcaagatga  ggatgagtt  gaggtgaac  tacatgtcc  3180
ggcacctga  ctgcagtct  acatcatcg  catcacggg  ctcgctgca  atttggacc  3240
ggccaaggc  ggactgctg  agcgtgtga  ggagctaca  gccgagcag  aggaccggg  3300
tttaaggag  tttaagctg  gtgtcactg  agaccccaa  taccatccc  agattatcg  3360
gagaaaggg  gcagtaatt  cccaaatcc  gttggagca  gacgtgaac  tccagtttc  3420
tgataagga  gatgggaac  agccccagg  ccaaattac  atcacaggg  acgaaaaga  3480
cacagaagc  gccagggat  ctatactga  aattgtggg  gaacttgag  agatggttt  3540
tgaggacgt  ccgctggac  accgcgttc  cgcccgcat  attggtgcc  gcggcaaag  3600
cattcgcaa  atcatggac  aattcaagg  ggacattcg  ttcccacag  gcggagccc  3660
agaccccaa  tgcgtcact  tgacggggc  cccagagaa  gtggaggaa  ccatcgacc  3720
catcctcaa  ctggaggag  aatacctag  tgacgtggt  gacagtgag  cgctgcagg  3780
atacatgaa  cccccagca  acgaagagg  caaggcacc  tccagaggc  ttgtggtgc  3840
ggacgcacc  tggaccgcc  gcagcagtg  gaaggctcc  gacatgagc  gctctgagg  3900
atttcccag  tttggggct  aggtggctc  caagaccct  ccttggggc  ccaaacgat  3960
atgatcaaa  agaacagaa  cctctccag  ctgctgacc  gaacccaac  acacaatgg  4020
ttgtctcaa  ctgacccag  ggctggacc  tccgtaaat  gttgagcgc  cttcccctt  4080
ccgaggtcc  cagggagcc  agcgcctgg  tgtgtgtgc  gccgctcct  caggcctgg  4140
cgtgcccgc  caggacctg  tccactgtt  aacaataaa  caaggtcat  agcattcga  4200
ctaagataa  agactccag  tcctggtcc  cccggcatg  cagtcagca  tctggcctt  4260
atcacgaga  ctccgcagc  gtggctagg  ttccacttc  tgtgtcatg  cctcaggaa  4320
taaacgtcc  tgactttat  aaagccccg  attc  4354



<210> 9090
<211> 1268
<212> PRT
<213> Homo sapiens
<308> Q00341
<400> 9090

Met Ser Ser Val Ala Val Leu Thr Gln Glu Ser Phe Ala Glu His Arg 
  1               5                  10                  15
Ser Gly Leu Val Pro Gln Gln Ile Lys Val Ala Thr Leu Asn Ser Glu 
             20                  25                  30
Glu Glu Ser Asp Pro Pro Thr Tyr Lys Asp Ala Phe Pro Pro Leu Pro 
         35                  40                  45
Glu Lys Ala Ala Cys Leu Glu Ser Ala Gln Glu Pro Ala Gly Ala Trp 
     50                  55                  60
Gly Asn Lys Ile Arg Pro Ile Lys Ala Ser Val Ile Thr Gln Val Phe 
 65                  70                  75                  80
His Val Pro Leu Glu Glu Arg Lys Tyr Lys Asp Met Asn Gln Phe Gly 
                 85                  90                  95
Glu Gly Glu Gln Ala Lys Ile Cys Leu Glu Ile Met Gln Arg Thr Gly 
             100                105                110
Ala His Leu Glu Leu Ser Leu Ala Lys Asp Gln Gly Leu Ser Ile Met 
         115                120                125
Val Ser Gly Lys Leu Asp Ala Val Met Lys Ala Arg Lys Asp Ile Val 
     130                135                140
Ala Arg Leu Gln Thr Gln Ala Ser Ala Thr Val Ala Ile Pro Lys Glu 
 145                150                155                160
His His Arg Phe Val Ile Gly Lys Asn Gly Glu Lys Leu Gln Asp Leu 
                 165                170                175
Glu Leu Lys Thr Ala Thr Lys Ile Gln Ile Pro Arg Pro Asp Asp Pro 
             180                185                190
Ser Asn Gln Ile Lys Ile Thr Gly Thr Lys Glu Gly Ile Glu Lys Ala 
         195                200                205
Arg His Glu Val Leu Leu Ile Ser Ala Glu Gln Asp Lys Arg Ala Val 
     210                215                220
Glu Arg Leu Glu Val Glu Lys Ala Phe His Pro Phe Ile Ala Gly Pro 
 225                230                235                240
Tyr Asn Arg Leu Val Gly Glu Ile Met Gln Glu Thr Gly Thr Arg Ile 
                 245                250                255
Asn Ile Pro Pro Pro Ser Val Asn Arg Thr Glu Ile Val Phe Thr Gly 
             260                265                270
Glu Lys Glu Gln Leu Ala Gln Ala Val Ala Arg Ile Lys Lys Ile Tyr 
         275                280                285
Glu Glu Lys Lys Lys Lys Thr Thr Thr Ile Ala Val Glu Val Lys Lys 
     290                295                300
Ser Gln His Lys Tyr Val Ile Gly Pro Lys Gly Asn Ser Leu Gln Glu 
 305                310                315                320
Ile Leu Glu Arg Thr Gly Val Ser Val Glu Ile Pro Pro Ser Asp Ser 
                 325                330                335
Ile Ser Glu Thr Val Ile Leu Arg Gly Glu Pro Glu Lys Leu Gly Gln 
             340                345                350
Ala Leu Thr Glu Val Tyr Ala Lys Ala Asn Ser Phe Thr Val Ser Ser 
         355                360                365
Val Ala Ala Pro Ser Trp Leu His Arg Phe Ile Ile Gly Lys Lys Gly 
     370                375                380
Gln Asn Leu Ala Lys Ile Thr Gln Gln Met Pro Lys Val His Ile Glu 
 385                390                395                400
Phe Thr Glu Gly Glu Asp Lys Ile Thr Leu Glu Gly Pro Thr Glu Asp 
                 405                410                415
Val Asn Val Ala Gln Glu Gln Ile Glu Gly Met Val Lys Asp Leu Ile 
             420                425                430
Asn Arg Met Asp Tyr Val Glu Ile Asn Ile Asp His Lys Phe His Arg 
         435                440                445
His Leu Ile Gly Lys Ser Gly Ala Asn Ile Asn Arg Ile Lys Asp Gln 
     450                455                460
Tyr Lys Val Ser Val Arg Ile Pro Pro Asp Ser Glu Lys Ser Asn Leu 
 465                470                475                480
Ile Arg Ile Glu Gly Asp Pro Gln Gly Val Gln Gln Ala Lys Arg Glu 
                 485                490                495
Leu Leu Glu Leu Ala Ser Arg Met Glu Asn Glu Arg Thr Lys Asp Leu 
             500                505                510
Ile Ile Glu Gln Arg Phe His Arg Thr Ile Ile Gly Gln Lys Gly Glu 
         515                520                525
Arg Ile Arg Glu Ile Arg Asp Lys Phe Pro Glu Val Ile Ile Asn Phe 
     530                535                540
Pro Asp Pro Ala Gln Lys Ser Asp Ile Val Gln Leu Arg Gly Pro Lys 
 545                550                555                560
Asn Glu Val Glu Lys Cys Thr Lys Tyr Met Gln Lys Met Val Ala Asp 
                 565                570                575
Leu Val Glu Asn Ser Tyr Ser Ile Ser Val Pro Ile Phe Lys Gln Phe 
             580                585                590
His Lys Asn Ile Ile Gly Lys Gly Gly Ala Asn Ile Lys Lys Ile Arg 
         595                600                605
Glu Glu Ser Asn Thr Lys Ile Asp Leu Pro Ala Glu Asn Ser Asn Ser 
     610                615                620
Glu Thr Ile Ile Ile Thr Gly Lys Arg Ala Asn Cys Glu Ala Ala Arg 
 625                630                635                640
Ser Arg Ile Leu Ser Ile Gln Lys Asp Leu Ala Asn Ile Ala Glu Val 
                 645                650                655
Glu Val Ser Ile Pro Ala Lys Leu His Asn Ser Leu Ile Gly Thr Lys 
             660                665                670
Gly Arg Leu Ile Arg Ser Ile Met Glu Glu Cys Gly Gly Val His Ile 
         675                680                685
His Phe Pro Val Glu Gly Ser Gly Ser Asp Thr Val Val Ile Arg Gly 
     690                695                700
Pro Ser Ser Asp Val Glu Lys Ala Lys Lys Gln Leu Leu His Leu Ala 
 705                710                715                720
Glu Glu Lys Gln Thr Lys Ser Phe Thr Val Asp Ile Arg Ala Lys Pro 
                 725                730                735
Glu Tyr His Lys Phe Leu Ile Gly Lys Gly Gly Gly Lys Ile Arg Lys 
             740                745                750
Val Arg Asp Ser Thr Gly Ala Arg Val Ile Phe Pro Ala Ala Glu Asp 
         755                760                765
Lys Asp Gln Asp Leu Ile Thr Ile Ile Gly Lys Glu Asp Ala Val Arg 
     770                775                780
Glu Ala Gln Lys Glu Leu Glu Ala Leu Ile Gln Asn Leu Asp Asn Val 
 785                790                795                800
Val Glu Asp Ser Met Leu Val Asp Pro Lys His His Arg His Phe Val 
                 805                810                815
Ile Arg Arg Gly Gln Val Leu Arg Glu Ile Ala Glu Glu Tyr Gly Gly 
             820                825                830
Val Met Val Ser Phe Pro Arg Ser Gly Thr Gln Ser Asp Lys Val Thr 
         835                840                845
Leu Lys Gly Ala Lys Asp Cys Val Glu Ala Ala Lys Lys Arg Ile Gln 
     850                855                860
Glu Ile Ile Glu Asp Leu Glu Ala Gln Val Thr Leu Glu Cys Ala Ile 
 865                870                875                880
Pro Gln Lys Phe His Arg Ser Val Met Gly Pro Lys Gly Ser Arg Ile 
                 885                890                895
Gln Gln Ile Thr Arg Asp Phe Ser Val Gln Ile Lys Phe Pro Asp Arg 
             900                905                910
Glu Glu Asn Ala Val His Ser Thr Glu Pro Val Val Gln Glu Asn Gly 
         915                920                925
Asp Glu Ala Gly Glu Gly Arg Glu Ala Lys Asp Cys Asp Pro Gly Ser 
     930                935                940
Pro Arg Arg Cys Asp Ile Ile Ile Ile Ser Gly Arg Lys Glu Lys Cys 
 945                950                955                960
Glu Ala Ala Lys Glu Ala Leu Glu Ala Leu Val Pro Val Thr Ile Glu 
                 965                970                975
Val Glu Val Pro Phe Asp Leu His Arg Tyr Val Ile Gly Gln Lys Gly 
             980                985                990
Ser Gly Ile Arg Lys Met Met Asp Glu Phe Glu Val Asn Ile His Val 
         995                1000                1005
Pro Ala Pro Glu Leu Gln Ser Asp Ile Ile Ala Ile Thr Gly Leu Ala 
     1010                1015                1020
Ala Asn Leu Asp Arg Ala Lys Ala Gly Leu Leu Glu Arg Val Lys Glu 
 1025                1030                1035                1040
Leu Gln Ala Glu Gln Glu Asp Arg Ala Leu Arg Ser Phe Lys Leu Ser 
                 1045                1050                1055
Val Thr Val Asp Pro Lys Tyr His Pro Lys Ile Ile Gly Arg Lys Gly 
             1060                1065                1070
Ala Val Ile Thr Gln Ile Arg Leu Glu His Asp Val Asn Ile Gln Phe 
         1075                1080                1085
Pro Asp Lys Asp Asp Gly Asn Gln Pro Gln Asp Gln Ile Thr Ile Thr 
     1090                1095                1100
Gly Tyr Glu Lys Asn Thr Glu Ala Ala Arg Asp Ala Ile Leu Arg Ile 
 1105                1110                1115                1120
Val Gly Glu Leu Glu Gln Met Val Ser Glu Asp Val Pro Leu Asp His 
                 1125                1130                1135
Arg Val His Ala Arg Ile Ile Gly Ala Arg Gly Lys Ala Ile Arg Lys 
             1140                1145                1150
Ile Met Asp Glu Phe Lys Val Asp Ile Arg Phe Pro Gln Ser Gly Ala 
         1155                1160                1165
Pro Asp Pro Asn Cys Val Thr Val Thr Gly Leu Pro Glu Asn Val Glu 
     1170                1175                1180
Glu Ala Ile Asp His Ile Leu Asn Leu Glu Glu Glu Tyr Leu Ala Asp 
 1185                1190                1195                1200
Val Val Asp Ser Glu Ala Leu Gln Val Tyr Met Lys Pro Pro Ala His 
                 1205                1210                1215
Glu Glu Ala Lys Ala Pro Ser Arg Gly Phe Val Val Arg Asp Ala Pro 
             1220                1225                1230
Trp Thr Ala Ser Ser Ser Glu Lys Ala Pro Asp Met Ser Ser Ser Glu 
         1235                1240                1245
Glu Phe Pro Ser Phe Gly Ala Gln Val Ala Pro Lys Thr Leu Pro Trp 
     1250                1255                1260
Gly Pro Lys Arg 
 1265



<210> 9091
<211> 1759
<212> DNA
<213> Rattus norvegicus
<308> U90829
<400> 9091

ctacttacg  ggctctgct  atcgtgggg  aagcgcggc  atggctcag  aagggaaga  60
actcaagga  caaaagtac  accggcagc  gaggttgtg  ggtgatcat  gtcaagaag  120
tttggaatc  gctcacgtt  gcttgataa  tgccacagc  acaggaacg  aaattctta  180
aaacttggt  ctgccaggt  taggatcat  tacaattat  gatggaaat  aggtcagcg  240
agaagatgt  ggaaacaat  ttttccttc  aaaatgcag  attggcaag  atcgagctc  300
agctgccat  gaattctta  aagagctaa  tagcgatgt  tctggaagt  ttgtggaag  360
gagtccaga  aaccttcta  acaatgatc  ttcattttt  tgtaggttt  ctattgtgg  420
tgcaactca  cttcttgaa  gtacattac  acgtttagc  gatgtcctc  ggaattccc  480
gatccctct  ttgatctgt  ggacatatg  cctagttgg  tatatgagg  ttattataa  540
agaacatcc  gtaatagaa  ctcatccag  taatgcatt  gaggaccta  gactagata  600
gccatttcc  gaactgaga  aacattttc  gtcttatga  ttggaccat  tggaaaaaa  660
ggaccatag  catactcca  ggattgtga  catagctaa  tatttagcc  agtggtata  720
tgagacaaa  ggacgaatt  ctaaaagtt  taaagaaaa  gaggacttc  gagaattga  780
aagacaagg  attttaaag  atgagaatg  agctccaga  gatgaagag  attttgaag  840
agctattaa  aatgtgaac  cagcactaa  tacaactca  atcccaagc  gtattgaag  900
tatatttaa  gatgatcgc  gcataaata  caccaaaca  accccatct  tttggattt  960
agctcgtgc  ttaaaggaa  ttgtggcca  ggagggtca  ggaaattta  ctgttcgag  1020
cacaattcc  gatatgatt  cagattcaa  caaatacat  aaattgcag  atgtttatc  1080
tgagaaagc  aagaaagat  ctgctgctg  aggtaatca  gttgccaaa  tgcttcagt  1140
ttgtggcca  gcaccagag  ccatttcag  gaaagaatt  aaactgctt  gtagcaatt  1200
tgcatttct  cgagtggta  gatgtcggt  tttagctga  gagtatggt  tgcatacag  1260
caacaaaga  gaaattatt  ctagcatgg  caatccgga  aatgagata  tcctgtacc  1320
aatgttgcg  gctgttgat  gatttcata  gcagcatgg  agataccca  gagtatcta  1380
ctatcaagt  gaagaagat  tagggaagt  gaagtcctg  cttactggc  tccttcagg  1440
atatgggtt  tctgtaatg  tgaaggacg  ttatgtcca  gaattttgc  ggtacggag  1500
tgctgagcc  cacaccgtt  ctgcattcc  gggaggagc  gctgctcaa  aagttatca  1560
aataatcac  aaacaattt  taattttta  caatactta  atttatagt  gtatgtcac  1620
aacttctgc  actttccaa  tgtagaata  gcaccccgt  taatatgtt  atggttgaa  1680
ctgtaattg  cttcctgtt  tgctttact  tgtaaacat  tgtttaggg  cagaagtta  1740
gttgtttcc  taataaaat  1759



<210> 9092
<211> 534
<212> PRT
<213> Rattus norvegicus
<308> AAD09247
<400> 9092

Met Ala Gln Gln Gly Lys Ile Leu Lys Glu Gln Lys Tyr Asp Arg Gln 
  1               5                  10                  15
Leu Arg Leu Trp Gly Asp His Gly Gln Glu Ala Leu Glu Ser Ala His 
             20                  25                  30
Val Cys Leu Ile Asn Ala Thr Ala Thr Gly Thr Glu Ile Leu Lys Asn 
         35                  40                  45
Leu Val Leu Pro Gly Ile Gly Ser Phe Thr Ile Ile Asp Gly Asn Gln 
     50                  55                  60
Val Ser Gly Glu Asp Val Gly Asn Asn Phe Phe Leu Gln Lys Cys Ser 
 65                  70                  75                  80
Ile Gly Lys Asn Arg Ala Gln Ala Ala Met Glu Phe Leu Gln Glu Leu 
                 85                  90                  95
Asn Ser Asp Val Ser Gly Ser Phe Val Glu Glu Ser Pro Glu Asn Leu 
             100                105                110
Leu Asp Asn Asp Pro Ser Phe Phe Cys Arg Phe Thr Ile Val Val Ala 
         115                120                125
Thr Gln Leu Leu Glu Ser Thr Leu Leu Arg Leu Ala Asp Val Leu Trp 
     130                135                140
Asn Ser Gln Ile Pro Leu Leu Ile Cys Arg Thr Tyr Gly Leu Val Gly 
 145                150                155                160
Tyr Met Arg Ile Ile Ile Lys Glu His Pro Val Ile Glu Ser His Pro 
                 165                170                175
Asp Asn Ala Leu Glu Asp Leu Arg Leu Asp Lys Pro Phe Pro Glu Leu 
             180                185                190
Arg Glu His Phe Gln Ser Tyr Asp Leu Asp His Met Glu Lys Lys Asp 
         195                200                205
His Ser His Thr Pro Trp Ile Val Ile Ile Ala Lys Tyr Leu Ala Gln 
     210                215                220
Trp Tyr Ser Glu Thr Asn Gly Arg Ile Pro Lys Ser Tyr Lys Glu Lys 
 225                230                235                240
Glu Asp Phe Arg Glu Leu Ile Arg Gln Gly Ile Leu Lys Asn Glu Asn 
                 245                250                255
Gly Ala Pro Glu Asp Glu Glu Asn Phe Glu Glu Ala Ile Lys Asn Val 
             260                265                270
Asn Thr Ala Leu Asn Thr Thr Gln Ile Pro Ser Ser Ile Glu Asp Ile 
         275                280                285
Phe Asn Asp Asp Arg Cys Ile Asn Ile Thr Lys Gln Thr Pro Ser Phe 
     290                295                300
Trp Ile Leu Ala Arg Ala Leu Lys Glu Phe Val Ala Lys Glu Gly Gln 
 305                310                315                320
Gly Asn Leu Pro Val Arg Gly Thr Ile Pro Asp Met Ile Ala Asp Ser 
                 325                330                335
Asn Lys Tyr Ile Lys Leu Gln Asn Val Tyr Arg Glu Lys Ala Lys Lys 
             340                345                350
Asp Ala Ala Ala Val Gly Asn His Val Ala Lys Leu Leu Gln Ser Cys 
         355                360                365
Gly Gln Ala Pro Glu Ser Ile Ser Glu Lys Glu Leu Lys Leu Leu Cys 
     370                375                380
Ser Asn Ser Ala Phe Leu Arg Val Val Arg Cys Arg Ser Leu Ala Glu 
 385                390                395                400
Glu Tyr Gly Leu His Thr Val Asn Lys Asp Glu Ile Ile Ser Ser Met 
                 405                410                415
Asp Asn Pro Asp Asn Glu Ile Val Leu Tyr Leu Met Leu Arg Ala Val 
             420                425                430
Asp Arg Phe His Lys Gln His Gly Arg Tyr Pro Gly Val Ser Asn Tyr 
         435                440                445
Gln Val Glu Glu Asp Ile Gly Lys Leu Lys Ser Cys Leu Thr Gly Phe 
     450                455                460
Leu Gln Glu Tyr Gly Leu Ser Val Met Val Lys Asp Asp Tyr Val His 
 465                470                475                480
Glu Phe Cys Arg Tyr Gly Ala Ala Glu Pro His Thr Val Ala Ala Phe 
                 485                490                495
Leu Gly Gly Ala Ala Ala Gln Glu Val Ile Lys Ile Ile Thr Lys Gln 
             500                505                510
Phe Val Ile Phe Asn Asn Thr Tyr Ile Tyr Ser Gly Met Ser Gln Thr 
         515                520                525
Ser Ala Thr Phe Gln Leu 
     530



<210> 9093
<211> 1823
<212> DNA
<213> Homo sapiens
<308> U50939
<400> 9093

gaattccgc  cttgtggag  tggtggcgg  gctccgcag  ggctcggct  ttttccgcg  60
ggcaggcgc  gccatggcg  agctgggaa  gctgctcaa  gagcagaag  acgaccggc  120
gctgaggtt  tggggtgat  atgggcaag  ggctttaga  tctgctcat  tttgcctaa  180
aaatgcaac  gccacagga  ctgaaattc  taaaaactt  gtactacca  gtattggtt  240
gtttacaat  attgatgga  atcaggtca  cggagaaga  gctggaaac  atttcttcc  300
tcaaagaag  agtatcggc  agaaccgag  tgaagctgc  atggaattc  tacaagaat  360
aaatagcga  gtctctgga  gttttgtgg  agagagtcc  gaaaacctt  tagacaatg  420
tccctcatt  ttctgtagg  ttactgttg  agttgcaac  cagcttcct  aaagcactt  480
actacgctt  gcagatgtc  tctggaatt  ccagattcc  cttttgatc  gtaggacat  540
tggactagt  ggttatatg  ggatcatta  aaaagaaca  ccagtaata  aatctcatc  600
agataatgc  ttagaggat  tacgactag  taagccatt  cctgaactg  gagaacatt  660
tcagtccta  gatttggat  atatggaaa  aaaggacca  agtcatact  catggattg  720
gatcatagc  aaatattta  cacagtggt  tagtgaaac  aatggacga  tacctaaaa  780
gtataaaga  aaagaggac  tcagagatt  gattagaca  ggaattcta  aaaatgaaa  840
tggggctcc  gaagatgaa  agaattttg  agaagctat  aaaaatgtg  acacagcac  900
aaatacaac  cagatccca  gcagtattg  agatatatt  aatgatgat  gctgcataa  960
tatcaccaa  cagactcca  cattttgga  tttagctcg  gccttaaag  aatttgtgg  1020
caaagaggg  caaggaaat  tacctgttc  aggcacaat  cctgatatg  ttgcagatt  1080
aggcaaata  ataaaactg  aaaacgttt  ccgtgaaaa  gcaaagaaa  atgctgccg  1140
tgtgggtaa  catgttgcc  aattgctgc  gtccattgg  caggcacca  agtccattt  1200
agagaaaga  ttaaaatta  tctgcagca  ttctgcatt  cttcgagtg  taagatgtc  1260
atccttagc  gaagaatat  gtttggata  aattaacaa  gatgaaatt  tttctagca  1320
ggacaatcc  gataatgaa  tagtgttgt  cttaatgtt  cgggctgtt  atagatttc  1380
taaacaaca  ggtagatat  caggagtat  taactatca  gttgaagaa  atataggaa  1440
gttgaagtc  tgtctcact  gcttccttc  ggaatatgg  ttatctgta  tggtgaaag  1500
tgattatgt  cacgaattt  gccgatatg  agctgctga  ccacatacc  ttgctgcat  1560
cttgggggg  gctgctgct  aagaggtca  caaaataat  accaaacaa  ttgtaattt  1620
taataatac  tacatttac  gtggcatgt  acaaacttc  gcaactttc  agttgtaga  1680
taagcaagc  ccttaagta  tgtgttaat  attgaaact  taattgcct  cgggttgtg  1740
tttagtctg  aaaattcta  aggagagct  ctaaattgt  ttcttaata  acatttttc  1800
catttgtaa  aaaaaagga  ttc  1823



<210> 9094
<211> 534
<212> PRT
<213> Homo sapiens
<308> NP_003896
<400> 9094

Met Ala Gln Leu Gly Lys Leu Leu Lys Glu Gln Lys Tyr Asp Arg Gln 
  1               5                  10                  15
Leu Arg Leu Trp Gly Asp His Gly Gln Glu Ala Leu Glu Ser Ala His 
             20                  25                  30
Val Cys Leu Ile Asn Ala Thr Ala Thr Gly Thr Glu Ile Leu Lys Asn 
         35                  40                  45
Leu Val Leu Pro Gly Ile Gly Ser Phe Thr Ile Ile Asp Gly Asn Gln 
     50                  55                  60
Val Ser Gly Glu Asp Ala Gly Asn Asn Phe Phe Leu Gln Arg Ser Ser 
 65                  70                  75                  80
Ile Gly Lys Asn Arg Ala Glu Ala Ala Met Glu Phe Leu Gln Glu Leu 
                 85                  90                  95
Asn Ser Asp Val Ser Gly Ser Phe Val Glu Glu Ser Pro Glu Asn Leu 
             100                105                110
Leu Asp Asn Asp Pro Ser Phe Phe Cys Arg Phe Thr Val Val Val Ala 
         115                120                125
Thr Gln Leu Pro Glu Ser Thr Ser Leu Arg Leu Ala Asp Val Leu Trp 
     130                135                140
Asn Ser Gln Ile Pro Leu Leu Ile Cys Arg Thr Tyr Gly Leu Val Gly 
 145                150                155                160
Tyr Met Arg Ile Ile Ile Lys Glu His Pro Val Ile Glu Ser His Pro 
                 165                170                175
Asp Asn Ala Leu Glu Asp Leu Arg Leu Asp Lys Pro Phe Pro Glu Leu 
             180                185                190
Arg Glu His Phe Gln Ser Tyr Asp Leu Asp His Met Glu Lys Lys Asp 
         195                200                205
His Ser His Thr Pro Trp Ile Val Ile Ile Ala Lys Tyr Leu Ala Gln 
     210                215                220
Trp Tyr Ser Glu Thr Asn Gly Arg Ile Pro Lys Thr Tyr Lys Glu Lys 
 225                230                235                240
Glu Asp Phe Arg Asp Leu Ile Arg Gln Gly Ile Leu Lys Asn Glu Asn 
                 245                250                255
Gly Ala Pro Glu Asp Glu Glu Asn Phe Glu Glu Ala Ile Lys Asn Val 
             260                265                270
Asn Thr Ala Leu Asn Thr Thr Gln Ile Pro Ser Ser Ile Glu Asp Ile 
         275                280                285
Phe Asn Asp Asp Arg Cys Ile Asn Ile Thr Lys Gln Thr Pro Ser Phe 
     290                295                300
Trp Ile Leu Ala Arg Ala Leu Lys Glu Phe Val Ala Lys Glu Gly Gln 
 305                310                315                320
Gly Asn Leu Pro Val Arg Gly Thr Ile Pro Asp Met Ile Ala Asp Ser 
                 325                330                335
Gly Lys Tyr Ile Lys Leu Gln Asn Val Tyr Arg Glu Lys Ala Lys Lys 
             340                345                350
Asp Ala Ala Ala Val Gly Asn His Val Ala Lys Leu Leu Gln Ser Ile 
         355                360                365
Gly Gln Ala Pro Glu Ser Ile Ser Glu Lys Glu Leu Lys Leu Leu Cys 
     370                375                380
Ser Asn Ser Ala Phe Leu Arg Val Val Arg Cys Arg Ser Leu Ala Glu 
 385                390                395                400
Glu Tyr Gly Leu Asp Thr Ile Asn Lys Asp Glu Ile Ile Ser Ser Met 
                 405                410                415
Asp Asn Pro Asp Asn Glu Ile Val Leu Tyr Leu Met Leu Arg Ala Val 
             420                425                430
Asp Arg Phe His Lys Gln Gln Gly Arg Tyr Pro Gly Val Ser Asn Tyr 
         435                440                445
Gln Val Glu Glu Asp Ile Gly Lys Leu Lys Ser Cys Leu Thr Gly Phe 
     450                455                460
Leu Gln Glu Tyr Gly Leu Ser Val Met Val Lys Asp Asp Tyr Val His 
 465                470                475                480
Glu Phe Cys Arg Tyr Gly Ala Ala Glu Pro His Thr Ile Ala Ala Phe 
                 485                490                495
Leu Gly Gly Ala Ala Ala Gln Glu Val Ile Lys Ile Ile Thr Lys Gln 
             500                505                510
Phe Val Ile Phe Asn Asn Thr Tyr Ile Tyr Ser Gly Met Ser Gln Thr 
         515                520                525
Ser Ala Thr Phe Gln Leu 
     530



<210> 9095
<211> 1759
<212> DNA
<213> Rattus norvegicus
<308> U90829
<400> 9095

ctacttacg  ggctctgct  atcgtgggg  aagcgcggc  atggctcag  aagggaaga  60
actcaagga  caaaagtac  accggcagc  gaggttgtg  ggtgatcat  gtcaagaag  120
tttggaatc  gctcacgtt  gcttgataa  tgccacagc  acaggaacg  aaattctta  180
aaacttggt  ctgccaggt  taggatcat  tacaattat  gatggaaat  aggtcagcg  240
agaagatgt  ggaaacaat  ttttccttc  aaaatgcag  attggcaag  atcgagctc  300
agctgccat  gaattctta  aagagctaa  tagcgatgt  tctggaagt  ttgtggaag  360
gagtccaga  aaccttcta  acaatgatc  ttcattttt  tgtaggttt  ctattgtgg  420
tgcaactca  cttcttgaa  gtacattac  acgtttagc  gatgtcctc  ggaattccc  480
gatccctct  ttgatctgt  ggacatatg  cctagttgg  tatatgagg  ttattataa  540
agaacatcc  gtaatagaa  ctcatccag  taatgcatt  gaggaccta  gactagata  600
gccatttcc  gaactgaga  aacattttc  gtcttatga  ttggaccat  tggaaaaaa  660
ggaccatag  catactcca  ggattgtga  catagctaa  tatttagcc  agtggtata  720
tgagacaaa  ggacgaatt  ctaaaagtt  taaagaaaa  gaggacttc  gagaattga  780
aagacaagg  attttaaag  atgagaatg  agctccaga  gatgaagag  attttgaag  840
agctattaa  aatgtgaac  cagcactaa  tacaactca  atcccaagc  gtattgaag  900
tatatttaa  gatgatcgc  gcataaata  caccaaaca  accccatct  tttggattt  960
agctcgtgc  ttaaaggaa  ttgtggcca  ggagggtca  ggaaattta  ctgttcgag  1020
cacaattcc  gatatgatt  cagattcaa  caaatacat  aaattgcag  atgtttatc  1080
tgagaaagc  aagaaagat  ctgctgctg  aggtaatca  gttgccaaa  tgcttcagt  1140
ttgtggcca  gcaccagag  ccatttcag  gaaagaatt  aaactgctt  gtagcaatt  1200
tgcatttct  cgagtggta  gatgtcggt  tttagctga  gagtatggt  tgcatacag  1260
caacaaaga  gaaattatt  ctagcatgg  caatccgga  aatgagata  tcctgtacc  1320
aatgttgcg  gctgttgat  gatttcata  gcagcatgg  agataccca  gagtatcta  1380
ctatcaagt  gaagaagat  tagggaagt  gaagtcctg  cttactggc  tccttcagg  1440
atatgggtt  tctgtaatg  tgaaggacg  ttatgtcca  gaattttgc  ggtacggag  1500
tgctgagcc  cacaccgtt  ctgcattcc  gggaggagc  gctgctcaa  aagttatca  1560
aataatcac  aaacaattt  taattttta  caatactta  atttatagt  gtatgtcac  1620
aacttctgc  actttccaa  tgtagaata  gcaccccgt  taatatgtt  atggttgaa  1680
ctgtaattg  cttcctgtt  tgctttact  tgtaaacat  tgtttaggg  cagaagtta  1740
gttgtttcc  taataaaat  1759



<210> 9096
<211> 534
<212> PRT
<213> Rattus norvegicus
<308> AAD09247
<400> 9096

Met Ala Gln Gln Gly Lys Ile Leu Lys Glu Gln Lys Tyr Asp Arg Gln 
  1               5                  10                  15
Leu Arg Leu Trp Gly Asp His Gly Gln Glu Ala Leu Glu Ser Ala His 
             20                  25                  30
Val Cys Leu Ile Asn Ala Thr Ala Thr Gly Thr Glu Ile Leu Lys Asn 
         35                  40                  45
Leu Val Leu Pro Gly Ile Gly Ser Phe Thr Ile Ile Asp Gly Asn Gln 
     50                  55                  60
Val Ser Gly Glu Asp Val Gly Asn Asn Phe Phe Leu Gln Lys Cys Ser 
 65                  70                  75                  80
Ile Gly Lys Asn Arg Ala Gln Ala Ala Met Glu Phe Leu Gln Glu Leu 
                 85                  90                  95
Asn Ser Asp Val Ser Gly Ser Phe Val Glu Glu Ser Pro Glu Asn Leu 
             100                105                110
Leu Asp Asn Asp Pro Ser Phe Phe Cys Arg Phe Thr Ile Val Val Ala 
         115                120                125
Thr Gln Leu Leu Glu Ser Thr Leu Leu Arg Leu Ala Asp Val Leu Trp 
     130                135                140
Asn Ser Gln Ile Pro Leu Leu Ile Cys Arg Thr Tyr Gly Leu Val Gly 
 145                150                155                160
Tyr Met Arg Ile Ile Ile Lys Glu His Pro Val Ile Glu Ser His Pro 
                 165                170                175
Asp Asn Ala Leu Glu Asp Leu Arg Leu Asp Lys Pro Phe Pro Glu Leu 
             180                185                190
Arg Glu His Phe Gln Ser Tyr Asp Leu Asp His Met Glu Lys Lys Asp 
         195                200                205
His Ser His Thr Pro Trp Ile Val Ile Ile Ala Lys Tyr Leu Ala Gln 
     210                215                220
Trp Tyr Ser Glu Thr Asn Gly Arg Ile Pro Lys Ser Tyr Lys Glu Lys 
 225                230                235                240
Glu Asp Phe Arg Glu Leu Ile Arg Gln Gly Ile Leu Lys Asn Glu Asn 
                 245                250                255
Gly Ala Pro Glu Asp Glu Glu Asn Phe Glu Glu Ala Ile Lys Asn Val 
             260                265                270
Asn Thr Ala Leu Asn Thr Thr Gln Ile Pro Ser Ser Ile Glu Asp Ile 
         275                280                285
Phe Asn Asp Asp Arg Cys Ile Asn Ile Thr Lys Gln Thr Pro Ser Phe 
     290                295                300
Trp Ile Leu Ala Arg Ala Leu Lys Glu Phe Val Ala Lys Glu Gly Gln 
 305                310                315                320
Gly Asn Leu Pro Val Arg Gly Thr Ile Pro Asp Met Ile Ala Asp Ser 
                 325                330                335
Asn Lys Tyr Ile Lys Leu Gln Asn Val Tyr Arg Glu Lys Ala Lys Lys 
             340                345                350
Asp Ala Ala Ala Val Gly Asn His Val Ala Lys Leu Leu Gln Ser Cys 
         355                360                365
Gly Gln Ala Pro Glu Ser Ile Ser Glu Lys Glu Leu Lys Leu Leu Cys 
     370                375                380
Ser Asn Ser Ala Phe Leu Arg Val Val Arg Cys Arg Ser Leu Ala Glu 
 385                390                395                400
Glu Tyr Gly Leu His Thr Val Asn Lys Asp Glu Ile Ile Ser Ser Met 
                 405                410                415
Asp Asn Pro Asp Asn Glu Ile Val Leu Tyr Leu Met Leu Arg Ala Val 
             420                425                430
Asp Arg Phe His Lys Gln His Gly Arg Tyr Pro Gly Val Ser Asn Tyr 
         435                440                445
Gln Val Glu Glu Asp Ile Gly Lys Leu Lys Ser Cys Leu Thr Gly Phe 
     450                455                460
Leu Gln Glu Tyr Gly Leu Ser Val Met Val Lys Asp Asp Tyr Val His 
 465                470                475                480
Glu Phe Cys Arg Tyr Gly Ala Ala Glu Pro His Thr Val Ala Ala Phe 
                 485                490                495
Leu Gly Gly Ala Ala Ala Gln Glu Val Ile Lys Ile Ile Thr Lys Gln 
             500                505                510
Phe Val Ile Phe Asn Asn Thr Tyr Ile Tyr Ser Gly Met Ser Gln Thr 
         515                520                525
Ser Ala Thr Phe Gln Leu 
     530



<210> 9097
<211> 1823
<212> DNA
<213> Homo sapiens
<308> U50939
<400> 9097

gaattccgc  cttgtggag  tggtggcgg  gctccgcag  ggctcggct  ttttccgcg  60
ggcaggcgc  gccatggcg  agctgggaa  gctgctcaa  gagcagaag  acgaccggc  120
gctgaggtt  tggggtgat  atgggcaag  ggctttaga  tctgctcat  tttgcctaa  180
aaatgcaac  gccacagga  ctgaaattc  taaaaactt  gtactacca  gtattggtt  240
gtttacaat  attgatgga  atcaggtca  cggagaaga  gctggaaac  atttcttcc  300
tcaaagaag  agtatcggc  agaaccgag  tgaagctgc  atggaattc  tacaagaat  360
aaatagcga  gtctctgga  gttttgtgg  agagagtcc  gaaaacctt  tagacaatg  420
tccctcatt  ttctgtagg  ttactgttg  agttgcaac  cagcttcct  aaagcactt  480
actacgctt  gcagatgtc  tctggaatt  ccagattcc  cttttgatc  gtaggacat  540
tggactagt  ggttatatg  ggatcatta  aaaagaaca  ccagtaata  aatctcatc  600
agataatgc  ttagaggat  tacgactag  taagccatt  cctgaactg  gagaacatt  660
tcagtccta  gatttggat  atatggaaa  aaaggacca  agtcatact  catggattg  720
gatcatagc  aaatattta  cacagtggt  tagtgaaac  aatggacga  tacctaaaa  780
gtataaaga  aaagaggac  tcagagatt  gattagaca  ggaattcta  aaaatgaaa  840
tggggctcc  gaagatgaa  agaattttg  agaagctat  aaaaatgtg  acacagcac  900
aaatacaac  cagatccca  gcagtattg  agatatatt  aatgatgat  gctgcataa  960
tatcaccaa  cagactcca  cattttgga  tttagctcg  gccttaaag  aatttgtgg  1020
caaagaggg  caaggaaat  tacctgttc  aggcacaat  cctgatatg  ttgcagatt  1080
aggcaaata  ataaaactg  aaaacgttt  ccgtgaaaa  gcaaagaaa  atgctgccg  1140
tgtgggtaa  catgttgcc  aattgctgc  gtccattgg  caggcacca  agtccattt  1200
agagaaaga  ttaaaatta  tctgcagca  ttctgcatt  cttcgagtg  taagatgtc  1260
atccttagc  gaagaatat  gtttggata  aattaacaa  gatgaaatt  tttctagca  1320
ggacaatcc  gataatgaa  tagtgttgt  cttaatgtt  cgggctgtt  atagatttc  1380
taaacaaca  ggtagatat  caggagtat  taactatca  gttgaagaa  atataggaa  1440
gttgaagtc  tgtctcact  gcttccttc  ggaatatgg  ttatctgta  tggtgaaag  1500
tgattatgt  cacgaattt  gccgatatg  agctgctga  ccacatacc  ttgctgcat  1560
cttgggggg  gctgctgct  aagaggtca  caaaataat  accaaacaa  ttgtaattt  1620
taataatac  tacatttac  gtggcatgt  acaaacttc  gcaactttc  agttgtaga  1680
taagcaagc  ccttaagta  tgtgttaat  attgaaact  taattgcct  cgggttgtg  1740
tttagtctg  aaaattcta  aggagagct  ctaaattgt  ttcttaata  acatttttc  1800
catttgtaa  aaaaaagga  ttc  1823



<210> 9098
<211> 534
<212> PRT
<213> Homo sapiens
<308> NP_003896
<400> 9098

Met Ala Gln Leu Gly Lys Leu Leu Lys Glu Gln Lys Tyr Asp Arg Gln 
  1               5                  10                  15
Leu Arg Leu Trp Gly Asp His Gly Gln Glu Ala Leu Glu Ser Ala His 
             20                  25                  30
Val Cys Leu Ile Asn Ala Thr Ala Thr Gly Thr Glu Ile Leu Lys Asn 
         35                  40                  45
Leu Val Leu Pro Gly Ile Gly Ser Phe Thr Ile Ile Asp Gly Asn Gln 
     50                  55                  60
Val Ser Gly Glu Asp Ala Gly Asn Asn Phe Phe Leu Gln Arg Ser Ser 
 65                  70                  75                  80
Ile Gly Lys Asn Arg Ala Glu Ala Ala Met Glu Phe Leu Gln Glu Leu 
                 85                  90                  95
Asn Ser Asp Val Ser Gly Ser Phe Val Glu Glu Ser Pro Glu Asn Leu 
             100                105                110
Leu Asp Asn Asp Pro Ser Phe Phe Cys Arg Phe Thr Val Val Val Ala 
         115                120                125
Thr Gln Leu Pro Glu Ser Thr Ser Leu Arg Leu Ala Asp Val Leu Trp 
     130                135                140
Asn Ser Gln Ile Pro Leu Leu Ile Cys Arg Thr Tyr Gly Leu Val Gly 
 145                150                155                160
Tyr Met Arg Ile Ile Ile Lys Glu His Pro Val Ile Glu Ser His Pro 
                 165                170                175
Asp Asn Ala Leu Glu Asp Leu Arg Leu Asp Lys Pro Phe Pro Glu Leu 
             180                185                190
Arg Glu His Phe Gln Ser Tyr Asp Leu Asp His Met Glu Lys Lys Asp 
         195                200                205
His Ser His Thr Pro Trp Ile Val Ile Ile Ala Lys Tyr Leu Ala Gln 
     210                215                220
Trp Tyr Ser Glu Thr Asn Gly Arg Ile Pro Lys Thr Tyr Lys Glu Lys 
 225                230                235                240
Glu Asp Phe Arg Asp Leu Ile Arg Gln Gly Ile Leu Lys Asn Glu Asn 
                 245                250                255
Gly Ala Pro Glu Asp Glu Glu Asn Phe Glu Glu Ala Ile Lys Asn Val 
             260                265                270
Asn Thr Ala Leu Asn Thr Thr Gln Ile Pro Ser Ser Ile Glu Asp Ile 
         275                280                285
Phe Asn Asp Asp Arg Cys Ile Asn Ile Thr Lys Gln Thr Pro Ser Phe 
     290                295                300
Trp Ile Leu Ala Arg Ala Leu Lys Glu Phe Val Ala Lys Glu Gly Gln 
 305                310                315                320
Gly Asn Leu Pro Val Arg Gly Thr Ile Pro Asp Met Ile Ala Asp Ser 
                 325                330                335
Gly Lys Tyr Ile Lys Leu Gln Asn Val Tyr Arg Glu Lys Ala Lys Lys 
             340                345                350
Asp Ala Ala Ala Val Gly Asn His Val Ala Lys Leu Leu Gln Ser Ile 
         355                360                365
Gly Gln Ala Pro Glu Ser Ile Ser Glu Lys Glu Leu Lys Leu Leu Cys 
     370                375                380
Ser Asn Ser Ala Phe Leu Arg Val Val Arg Cys Arg Ser Leu Ala Glu 
 385                390                395                400
Glu Tyr Gly Leu Asp Thr Ile Asn Lys Asp Glu Ile Ile Ser Ser Met 
                 405                410                415
Asp Asn Pro Asp Asn Glu Ile Val Leu Tyr Leu Met Leu Arg Ala Val 
             420                425                430
Asp Arg Phe His Lys Gln Gln Gly Arg Tyr Pro Gly Val Ser Asn Tyr 
         435                440                445
Gln Val Glu Glu Asp Ile Gly Lys Leu Lys Ser Cys Leu Thr Gly Phe 
     450                455                460
Leu Gln Glu Tyr Gly Leu Ser Val Met Val Lys Asp Asp Tyr Val His 
 465                470                475                480
Glu Phe Cys Arg Tyr Gly Ala Ala Glu Pro His Thr Ile Ala Ala Phe 
                 485                490                495
Leu Gly Gly Ala Ala Ala Gln Glu Val Ile Lys Ile Ile Thr Lys Gln 
             500                505                510
Phe Val Ile Phe Asn Asn Thr Tyr Ile Tyr Ser Gly Met Ser Gln Thr 
         515                520                525
Ser Ala Thr Phe Gln Leu 
     530



<210> 9099
<211> 1759
<212> DNA
<213> Rattus norvegicus
<308> U90829
<400> 9099

ctacttacg  ggctctgct  atcgtgggg  aagcgcggc  atggctcag  aagggaaga  60
actcaagga  caaaagtac  accggcagc  gaggttgtg  ggtgatcat  gtcaagaag  120
tttggaatc  gctcacgtt  gcttgataa  tgccacagc  acaggaacg  aaattctta  180
aaacttggt  ctgccaggt  taggatcat  tacaattat  gatggaaat  aggtcagcg  240
agaagatgt  ggaaacaat  ttttccttc  aaaatgcag  attggcaag  atcgagctc  300
agctgccat  gaattctta  aagagctaa  tagcgatgt  tctggaagt  ttgtggaag  360
gagtccaga  aaccttcta  acaatgatc  ttcattttt  tgtaggttt  ctattgtgg  420
tgcaactca  cttcttgaa  gtacattac  acgtttagc  gatgtcctc  ggaattccc  480
gatccctct  ttgatctgt  ggacatatg  cctagttgg  tatatgagg  ttattataa  540
agaacatcc  gtaatagaa  ctcatccag  taatgcatt  gaggaccta  gactagata  600
gccatttcc  gaactgaga  aacattttc  gtcttatga  ttggaccat  tggaaaaaa  660
ggaccatag  catactcca  ggattgtga  catagctaa  tatttagcc  agtggtata  720
tgagacaaa  ggacgaatt  ctaaaagtt  taaagaaaa  gaggacttc  gagaattga  780
aagacaagg  attttaaag  atgagaatg  agctccaga  gatgaagag  attttgaag  840
agctattaa  aatgtgaac  cagcactaa  tacaactca  atcccaagc  gtattgaag  900
tatatttaa  gatgatcgc  gcataaata  caccaaaca  accccatct  tttggattt  960
agctcgtgc  ttaaaggaa  ttgtggcca  ggagggtca  ggaaattta  ctgttcgag  1020
cacaattcc  gatatgatt  cagattcaa  caaatacat  aaattgcag  atgtttatc  1080
tgagaaagc  aagaaagat  ctgctgctg  aggtaatca  gttgccaaa  tgcttcagt  1140
ttgtggcca  gcaccagag  ccatttcag  gaaagaatt  aaactgctt  gtagcaatt  1200
tgcatttct  cgagtggta  gatgtcggt  tttagctga  gagtatggt  tgcatacag  1260
caacaaaga  gaaattatt  ctagcatgg  caatccgga  aatgagata  tcctgtacc  1320
aatgttgcg  gctgttgat  gatttcata  gcagcatgg  agataccca  gagtatcta  1380
ctatcaagt  gaagaagat  tagggaagt  gaagtcctg  cttactggc  tccttcagg  1440
atatgggtt  tctgtaatg  tgaaggacg  ttatgtcca  gaattttgc  ggtacggag  1500
tgctgagcc  cacaccgtt  ctgcattcc  gggaggagc  gctgctcaa  aagttatca  1560
aataatcac  aaacaattt  taattttta  caatactta  atttatagt  gtatgtcac  1620
aacttctgc  actttccaa  tgtagaata  gcaccccgt  taatatgtt  atggttgaa  1680
ctgtaattg  cttcctgtt  tgctttact  tgtaaacat  tgtttaggg  cagaagtta  1740
gttgtttcc  taataaaat  1759



<210> 9100
<211> 534
<212> PRT
<213> Rattus norvegicus
<308> AAD09247
<400> 9100

Met Ala Gln Gln Gly Lys Ile Leu Lys Glu Gln Lys Tyr Asp Arg Gln 
  1               5                  10                  15
Leu Arg Leu Trp Gly Asp His Gly Gln Glu Ala Leu Glu Ser Ala His 
             20                  25                  30
Val Cys Leu Ile Asn Ala Thr Ala Thr Gly Thr Glu Ile Leu Lys Asn 
         35                  40                  45
Leu Val Leu Pro Gly Ile Gly Ser Phe Thr Ile Ile Asp Gly Asn Gln 
     50                  55                  60
Val Ser Gly Glu Asp Val Gly Asn Asn Phe Phe Leu Gln Lys Cys Ser 
 65                  70                  75                  80
Ile Gly Lys Asn Arg Ala Gln Ala Ala Met Glu Phe Leu Gln Glu Leu 
                 85                  90                  95
Asn Ser Asp Val Ser Gly Ser Phe Val Glu Glu Ser Pro Glu Asn Leu 
             100                105                110
Leu Asp Asn Asp Pro Ser Phe Phe Cys Arg Phe Thr Ile Val Val Ala 
         115                120                125
Thr Gln Leu Leu Glu Ser Thr Leu Leu Arg Leu Ala Asp Val Leu Trp 
     130                135                140
Asn Ser Gln Ile Pro Leu Leu Ile Cys Arg Thr Tyr Gly Leu Val Gly 
 145                150                155                160
Tyr Met Arg Ile Ile Ile Lys Glu His Pro Val Ile Glu Ser His Pro 
                 165                170                175
Asp Asn Ala Leu Glu Asp Leu Arg Leu Asp Lys Pro Phe Pro Glu Leu 
             180                185                190
Arg Glu His Phe Gln Ser Tyr Asp Leu Asp His Met Glu Lys Lys Asp 
         195                200                205
His Ser His Thr Pro Trp Ile Val Ile Ile Ala Lys Tyr Leu Ala Gln 
     210                215                220
Trp Tyr Ser Glu Thr Asn Gly Arg Ile Pro Lys Ser Tyr Lys Glu Lys 
 225                230                235                240
Glu Asp Phe Arg Glu Leu Ile Arg Gln Gly Ile Leu Lys Asn Glu Asn 
                 245                250                255
Gly Ala Pro Glu Asp Glu Glu Asn Phe Glu Glu Ala Ile Lys Asn Val 
             260                265                270
Asn Thr Ala Leu Asn Thr Thr Gln Ile Pro Ser Ser Ile Glu Asp Ile 
         275                280                285
Phe Asn Asp Asp Arg Cys Ile Asn Ile Thr Lys Gln Thr Pro Ser Phe 
     290                295                300
Trp Ile Leu Ala Arg Ala Leu Lys Glu Phe Val Ala Lys Glu Gly Gln 
 305                310                315                320
Gly Asn Leu Pro Val Arg Gly Thr Ile Pro Asp Met Ile Ala Asp Ser 
                 325                330                335
Asn Lys Tyr Ile Lys Leu Gln Asn Val Tyr Arg Glu Lys Ala Lys Lys 
             340                345                350
Asp Ala Ala Ala Val Gly Asn His Val Ala Lys Leu Leu Gln Ser Cys 
         355                360                365
Gly Gln Ala Pro Glu Ser Ile Ser Glu Lys Glu Leu Lys Leu Leu Cys 
     370                375                380
Ser Asn Ser Ala Phe Leu Arg Val Val Arg Cys Arg Ser Leu Ala Glu 
 385                390                395                400
Glu Tyr Gly Leu His Thr Val Asn Lys Asp Glu Ile Ile Ser Ser Met 
                 405                410                415
Asp Asn Pro Asp Asn Glu Ile Val Leu Tyr Leu Met Leu Arg Ala Val 
             420                425                430
Asp Arg Phe His Lys Gln His Gly Arg Tyr Pro Gly Val Ser Asn Tyr 
         435                440                445
Gln Val Glu Glu Asp Ile Gly Lys Leu Lys Ser Cys Leu Thr Gly Phe 
     450                455                460
Leu Gln Glu Tyr Gly Leu Ser Val Met Val Lys Asp Asp Tyr Val His 
 465                470                475                480
Glu Phe Cys Arg Tyr Gly Ala Ala Glu Pro His Thr Val Ala Ala Phe 
                 485                490                495
Leu Gly Gly Ala Ala Ala Gln Glu Val Ile Lys Ile Ile Thr Lys Gln 
             500                505                510
Phe Val Ile Phe Asn Asn Thr Tyr Ile Tyr Ser Gly Met Ser Gln Thr 
         515                520                525
Ser Ala Thr Phe Gln Leu 
     530



<210> 9101
<211> 1823
<212> DNA
<213> Homo sapiens
<308> U50939
<400> 9101

gaattccgc  cttgtggag  tggtggcgg  gctccgcag  ggctcggct  ttttccgcg  60
ggcaggcgc  gccatggcg  agctgggaa  gctgctcaa  gagcagaag  acgaccggc  120
gctgaggtt  tggggtgat  atgggcaag  ggctttaga  tctgctcat  tttgcctaa  180
aaatgcaac  gccacagga  ctgaaattc  taaaaactt  gtactacca  gtattggtt  240
gtttacaat  attgatgga  atcaggtca  cggagaaga  gctggaaac  atttcttcc  300
tcaaagaag  agtatcggc  agaaccgag  tgaagctgc  atggaattc  tacaagaat  360
aaatagcga  gtctctgga  gttttgtgg  agagagtcc  gaaaacctt  tagacaatg  420
tccctcatt  ttctgtagg  ttactgttg  agttgcaac  cagcttcct  aaagcactt  480
actacgctt  gcagatgtc  tctggaatt  ccagattcc  cttttgatc  gtaggacat  540
tggactagt  ggttatatg  ggatcatta  aaaagaaca  ccagtaata  aatctcatc  600
agataatgc  ttagaggat  tacgactag  taagccatt  cctgaactg  gagaacatt  660
tcagtccta  gatttggat  atatggaaa  aaaggacca  agtcatact  catggattg  720
gatcatagc  aaatattta  cacagtggt  tagtgaaac  aatggacga  tacctaaaa  780
gtataaaga  aaagaggac  tcagagatt  gattagaca  ggaattcta  aaaatgaaa  840
tggggctcc  gaagatgaa  agaattttg  agaagctat  aaaaatgtg  acacagcac  900
aaatacaac  cagatccca  gcagtattg  agatatatt  aatgatgat  gctgcataa  960
tatcaccaa  cagactcca  cattttgga  tttagctcg  gccttaaag  aatttgtgg  1020
caaagaggg  caaggaaat  tacctgttc  aggcacaat  cctgatatg  ttgcagatt  1080
aggcaaata  ataaaactg  aaaacgttt  ccgtgaaaa  gcaaagaaa  atgctgccg  1140
tgtgggtaa  catgttgcc  aattgctgc  gtccattgg  caggcacca  agtccattt  1200
agagaaaga  ttaaaatta  tctgcagca  ttctgcatt  cttcgagtg  taagatgtc  1260
atccttagc  gaagaatat  gtttggata  aattaacaa  gatgaaatt  tttctagca  1320
ggacaatcc  gataatgaa  tagtgttgt  cttaatgtt  cgggctgtt  atagatttc  1380
taaacaaca  ggtagatat  caggagtat  taactatca  gttgaagaa  atataggaa  1440
gttgaagtc  tgtctcact  gcttccttc  ggaatatgg  ttatctgta  tggtgaaag  1500
tgattatgt  cacgaattt  gccgatatg  agctgctga  ccacatacc  ttgctgcat  1560
cttgggggg  gctgctgct  aagaggtca  caaaataat  accaaacaa  ttgtaattt  1620
taataatac  tacatttac  gtggcatgt  acaaacttc  gcaactttc  agttgtaga  1680
taagcaagc  ccttaagta  tgtgttaat  attgaaact  taattgcct  cgggttgtg  1740
tttagtctg  aaaattcta  aggagagct  ctaaattgt  ttcttaata  acatttttc  1800
catttgtaa  aaaaaagga  ttc  1823



<210> 9102
<211> 534
<212> PRT
<213> Homo sapiens
<308> NP_003896
<400> 9102

Met Ala Gln Leu Gly Lys Leu Leu Lys Glu Gln Lys Tyr Asp Arg Gln 
  1               5                  10                  15
Leu Arg Leu Trp Gly Asp His Gly Gln Glu Ala Leu Glu Ser Ala His 
             20                  25                  30
Val Cys Leu Ile Asn Ala Thr Ala Thr Gly Thr Glu Ile Leu Lys Asn 
         35                  40                  45
Leu Val Leu Pro Gly Ile Gly Ser Phe Thr Ile Ile Asp Gly Asn Gln 
     50                  55                  60
Val Ser Gly Glu Asp Ala Gly Asn Asn Phe Phe Leu Gln Arg Ser Ser 
 65                  70                  75                  80
Ile Gly Lys Asn Arg Ala Glu Ala Ala Met Glu Phe Leu Gln Glu Leu 
                 85                  90                  95
Asn Ser Asp Val Ser Gly Ser Phe Val Glu Glu Ser Pro Glu Asn Leu 
             100                105                110
Leu Asp Asn Asp Pro Ser Phe Phe Cys Arg Phe Thr Val Val Val Ala 
         115                120                125
Thr Gln Leu Pro Glu Ser Thr Ser Leu Arg Leu Ala Asp Val Leu Trp 
     130                135                140
Asn Ser Gln Ile Pro Leu Leu Ile Cys Arg Thr Tyr Gly Leu Val Gly 
 145                150                155                160
Tyr Met Arg Ile Ile Ile Lys Glu His Pro Val Ile Glu Ser His Pro 
                 165                170                175
Asp Asn Ala Leu Glu Asp Leu Arg Leu Asp Lys Pro Phe Pro Glu Leu 
             180                185                190
Arg Glu His Phe Gln Ser Tyr Asp Leu Asp His Met Glu Lys Lys Asp 
         195                200                205
His Ser His Thr Pro Trp Ile Val Ile Ile Ala Lys Tyr Leu Ala Gln 
     210                215                220
Trp Tyr Ser Glu Thr Asn Gly Arg Ile Pro Lys Thr Tyr Lys Glu Lys 
 225                230                235                240
Glu Asp Phe Arg Asp Leu Ile Arg Gln Gly Ile Leu Lys Asn Glu Asn 
                 245                250                255
Gly Ala Pro Glu Asp Glu Glu Asn Phe Glu Glu Ala Ile Lys Asn Val 
             260                265                270
Asn Thr Ala Leu Asn Thr Thr Gln Ile Pro Ser Ser Ile Glu Asp Ile 
         275                280                285
Phe Asn Asp Asp Arg Cys Ile Asn Ile Thr Lys Gln Thr Pro Ser Phe 
     290                295                300
Trp Ile Leu Ala Arg Ala Leu Lys Glu Phe Val Ala Lys Glu Gly Gln 
 305                310                315                320
Gly Asn Leu Pro Val Arg Gly Thr Ile Pro Asp Met Ile Ala Asp Ser 
                 325                330                335
Gly Lys Tyr Ile Lys Leu Gln Asn Val Tyr Arg Glu Lys Ala Lys Lys 
             340                345                350
Asp Ala Ala Ala Val Gly Asn His Val Ala Lys Leu Leu Gln Ser Ile 
         355                360                365
Gly Gln Ala Pro Glu Ser Ile Ser Glu Lys Glu Leu Lys Leu Leu Cys 
     370                375                380
Ser Asn Ser Ala Phe Leu Arg Val Val Arg Cys Arg Ser Leu Ala Glu 
 385                390                395                400
Glu Tyr Gly Leu Asp Thr Ile Asn Lys Asp Glu Ile Ile Ser Ser Met 
                 405                410                415
Asp Asn Pro Asp Asn Glu Ile Val Leu Tyr Leu Met Leu Arg Ala Val 
             420                425                430
Asp Arg Phe His Lys Gln Gln Gly Arg Tyr Pro Gly Val Ser Asn Tyr 
         435                440                445
Gln Val Glu Glu Asp Ile Gly Lys Leu Lys Ser Cys Leu Thr Gly Phe 
     450                455                460
Leu Gln Glu Tyr Gly Leu Ser Val Met Val Lys Asp Asp Tyr Val His 
 465                470                475                480
Glu Phe Cys Arg Tyr Gly Ala Ala Glu Pro His Thr Ile Ala Ala Phe 
                 485                490                495
Leu Gly Gly Ala Ala Ala Gln Glu Val Ile Lys Ile Ile Thr Lys Gln 
             500                505                510
Phe Val Ile Phe Asn Asn Thr Tyr Ile Tyr Ser Gly Met Ser Gln Thr 
         515                520                525
Ser Ala Thr Phe Gln Leu 
     530



<210> 9103
<211> 1759
<212> DNA
<213> Rattus norvegicus
<308> U90829
<400> 9103

ctacttacg  ggctctgct  atcgtgggg  aagcgcggc  atggctcag  aagggaaga  60
actcaagga  caaaagtac  accggcagc  gaggttgtg  ggtgatcat  gtcaagaag  120
tttggaatc  gctcacgtt  gcttgataa  tgccacagc  acaggaacg  aaattctta  180
aaacttggt  ctgccaggt  taggatcat  tacaattat  gatggaaat  aggtcagcg  240
agaagatgt  ggaaacaat  ttttccttc  aaaatgcag  attggcaag  atcgagctc  300
agctgccat  gaattctta  aagagctaa  tagcgatgt  tctggaagt  ttgtggaag  360
gagtccaga  aaccttcta  acaatgatc  ttcattttt  tgtaggttt  ctattgtgg  420
tgcaactca  cttcttgaa  gtacattac  acgtttagc  gatgtcctc  ggaattccc  480
gatccctct  ttgatctgt  ggacatatg  cctagttgg  tatatgagg  ttattataa  540
agaacatcc  gtaatagaa  ctcatccag  taatgcatt  gaggaccta  gactagata  600
gccatttcc  gaactgaga  aacattttc  gtcttatga  ttggaccat  tggaaaaaa  660
ggaccatag  catactcca  ggattgtga  catagctaa  tatttagcc  agtggtata  720
tgagacaaa  ggacgaatt  ctaaaagtt  taaagaaaa  gaggacttc  gagaattga  780
aagacaagg  attttaaag  atgagaatg  agctccaga  gatgaagag  attttgaag  840
agctattaa  aatgtgaac  cagcactaa  tacaactca  atcccaagc  gtattgaag  900
tatatttaa  gatgatcgc  gcataaata  caccaaaca  accccatct  tttggattt  960
agctcgtgc  ttaaaggaa  ttgtggcca  ggagggtca  ggaaattta  ctgttcgag  1020
cacaattcc  gatatgatt  cagattcaa  caaatacat  aaattgcag  atgtttatc  1080
tgagaaagc  aagaaagat  ctgctgctg  aggtaatca  gttgccaaa  tgcttcagt  1140
ttgtggcca  gcaccagag  ccatttcag  gaaagaatt  aaactgctt  gtagcaatt  1200
tgcatttct  cgagtggta  gatgtcggt  tttagctga  gagtatggt  tgcatacag  1260
caacaaaga  gaaattatt  ctagcatgg  caatccgga  aatgagata  tcctgtacc  1320
aatgttgcg  gctgttgat  gatttcata  gcagcatgg  agataccca  gagtatcta  1380
ctatcaagt  gaagaagat  tagggaagt  gaagtcctg  cttactggc  tccttcagg  1440
atatgggtt  tctgtaatg  tgaaggacg  ttatgtcca  gaattttgc  ggtacggag  1500
tgctgagcc  cacaccgtt  ctgcattcc  gggaggagc  gctgctcaa  aagttatca  1560
aataatcac  aaacaattt  taattttta  caatactta  atttatagt  gtatgtcac  1620
aacttctgc  actttccaa  tgtagaata  gcaccccgt  taatatgtt  atggttgaa  1680
ctgtaattg  cttcctgtt  tgctttact  tgtaaacat  tgtttaggg  cagaagtta  1740
gttgtttcc  taataaaat  1759



<210> 9104
<211> 534
<212> PRT
<213> Rattus norvegicus
<308> AAD09247
<400> 9104

Met Ala Gln Gln Gly Lys Ile Leu Lys Glu Gln Lys Tyr Asp Arg Gln 
  1               5                  10                  15
Leu Arg Leu Trp Gly Asp His Gly Gln Glu Ala Leu Glu Ser Ala His 
             20                  25                  30
Val Cys Leu Ile Asn Ala Thr Ala Thr Gly Thr Glu Ile Leu Lys Asn 
         35                  40                  45
Leu Val Leu Pro Gly Ile Gly Ser Phe Thr Ile Ile Asp Gly Asn Gln 
     50                  55                  60
Val Ser Gly Glu Asp Val Gly Asn Asn Phe Phe Leu Gln Lys Cys Ser 
 65                  70                  75                  80
Ile Gly Lys Asn Arg Ala Gln Ala Ala Met Glu Phe Leu Gln Glu Leu 
                 85                  90                  95
Asn Ser Asp Val Ser Gly Ser Phe Val Glu Glu Ser Pro Glu Asn Leu 
             100                105                110
Leu Asp Asn Asp Pro Ser Phe Phe Cys Arg Phe Thr Ile Val Val Ala 
         115                120                125
Thr Gln Leu Leu Glu Ser Thr Leu Leu Arg Leu Ala Asp Val Leu Trp 
     130                135                140
Asn Ser Gln Ile Pro Leu Leu Ile Cys Arg Thr Tyr Gly Leu Val Gly 
 145                150                155                160
Tyr Met Arg Ile Ile Ile Lys Glu His Pro Val Ile Glu Ser His Pro 
                 165                170                175
Asp Asn Ala Leu Glu Asp Leu Arg Leu Asp Lys Pro Phe Pro Glu Leu 
             180                185                190
Arg Glu His Phe Gln Ser Tyr Asp Leu Asp His Met Glu Lys Lys Asp 
         195                200                205
His Ser His Thr Pro Trp Ile Val Ile Ile Ala Lys Tyr Leu Ala Gln 
     210                215                220
Trp Tyr Ser Glu Thr Asn Gly Arg Ile Pro Lys Ser Tyr Lys Glu Lys 
 225                230                235                240
Glu Asp Phe Arg Glu Leu Ile Arg Gln Gly Ile Leu Lys Asn Glu Asn 
                 245                250                255
Gly Ala Pro Glu Asp Glu Glu Asn Phe Glu Glu Ala Ile Lys Asn Val 
             260                265                270
Asn Thr Ala Leu Asn Thr Thr Gln Ile Pro Ser Ser Ile Glu Asp Ile 
         275                280                285
Phe Asn Asp Asp Arg Cys Ile Asn Ile Thr Lys Gln Thr Pro Ser Phe 
     290                295                300
Trp Ile Leu Ala Arg Ala Leu Lys Glu Phe Val Ala Lys Glu Gly Gln 
 305                310                315                320
Gly Asn Leu Pro Val Arg Gly Thr Ile Pro Asp Met Ile Ala Asp Ser 
                 325                330                335
Asn Lys Tyr Ile Lys Leu Gln Asn Val Tyr Arg Glu Lys Ala Lys Lys 
             340                345                350
Asp Ala Ala Ala Val Gly Asn His Val Ala Lys Leu Leu Gln Ser Cys 
         355                360                365
Gly Gln Ala Pro Glu Ser Ile Ser Glu Lys Glu Leu Lys Leu Leu Cys 
     370                375                380
Ser Asn Ser Ala Phe Leu Arg Val Val Arg Cys Arg Ser Leu Ala Glu 
 385                390                395                400
Glu Tyr Gly Leu His Thr Val Asn Lys Asp Glu Ile Ile Ser Ser Met 
                 405                410                415
Asp Asn Pro Asp Asn Glu Ile Val Leu Tyr Leu Met Leu Arg Ala Val 
             420                425                430
Asp Arg Phe His Lys Gln His Gly Arg Tyr Pro Gly Val Ser Asn Tyr 
         435                440                445
Gln Val Glu Glu Asp Ile Gly Lys Leu Lys Ser Cys Leu Thr Gly Phe 
     450                455                460
Leu Gln Glu Tyr Gly Leu Ser Val Met Val Lys Asp Asp Tyr Val His 
 465                470                475                480
Glu Phe Cys Arg Tyr Gly Ala Ala Glu Pro His Thr Val Ala Ala Phe 
                 485                490                495
Leu Gly Gly Ala Ala Ala Gln Glu Val Ile Lys Ile Ile Thr Lys Gln 
             500                505                510
Phe Val Ile Phe Asn Asn Thr Tyr Ile Tyr Ser Gly Met Ser Gln Thr 
         515                520                525
Ser Ala Thr Phe Gln Leu 
     530



<210> 9105
<211> 1823
<212> DNA
<213> Homo sapiens
<308> U50939
<400> 9105

gaattccgc  cttgtggag  tggtggcgg  gctccgcag  ggctcggct  ttttccgcg  60
ggcaggcgc  gccatggcg  agctgggaa  gctgctcaa  gagcagaag  acgaccggc  120
gctgaggtt  tggggtgat  atgggcaag  ggctttaga  tctgctcat  tttgcctaa  180
aaatgcaac  gccacagga  ctgaaattc  taaaaactt  gtactacca  gtattggtt  240
gtttacaat  attgatgga  atcaggtca  cggagaaga  gctggaaac  atttcttcc  300
tcaaagaag  agtatcggc  agaaccgag  tgaagctgc  atggaattc  tacaagaat  360
aaatagcga  gtctctgga  gttttgtgg  agagagtcc  gaaaacctt  tagacaatg  420
tccctcatt  ttctgtagg  ttactgttg  agttgcaac  cagcttcct  aaagcactt  480
actacgctt  gcagatgtc  tctggaatt  ccagattcc  cttttgatc  gtaggacat  540
tggactagt  ggttatatg  ggatcatta  aaaagaaca  ccagtaata  aatctcatc  600
agataatgc  ttagaggat  tacgactag  taagccatt  cctgaactg  gagaacatt  660
tcagtccta  gatttggat  atatggaaa  aaaggacca  agtcatact  catggattg  720
gatcatagc  aaatattta  cacagtggt  tagtgaaac  aatggacga  tacctaaaa  780
gtataaaga  aaagaggac  tcagagatt  gattagaca  ggaattcta  aaaatgaaa  840
tggggctcc  gaagatgaa  agaattttg  agaagctat  aaaaatgtg  acacagcac  900
aaatacaac  cagatccca  gcagtattg  agatatatt  aatgatgat  gctgcataa  960
tatcaccaa  cagactcca  cattttgga  tttagctcg  gccttaaag  aatttgtgg  1020
caaagaggg  caaggaaat  tacctgttc  aggcacaat  cctgatatg  ttgcagatt  1080
aggcaaata  ataaaactg  aaaacgttt  ccgtgaaaa  gcaaagaaa  atgctgccg  1140
tgtgggtaa  catgttgcc  aattgctgc  gtccattgg  caggcacca  agtccattt  1200
agagaaaga  ttaaaatta  tctgcagca  ttctgcatt  cttcgagtg  taagatgtc  1260
atccttagc  gaagaatat  gtttggata  aattaacaa  gatgaaatt  tttctagca  1320
ggacaatcc  gataatgaa  tagtgttgt  cttaatgtt  cgggctgtt  atagatttc  1380
taaacaaca  ggtagatat  caggagtat  taactatca  gttgaagaa  atataggaa  1440
gttgaagtc  tgtctcact  gcttccttc  ggaatatgg  ttatctgta  tggtgaaag  1500
tgattatgt  cacgaattt  gccgatatg  agctgctga  ccacatacc  ttgctgcat  1560
cttgggggg  gctgctgct  aagaggtca  caaaataat  accaaacaa  ttgtaattt  1620
taataatac  tacatttac  gtggcatgt  acaaacttc  gcaactttc  agttgtaga  1680
taagcaagc  ccttaagta  tgtgttaat  attgaaact  taattgcct  cgggttgtg  1740
tttagtctg  aaaattcta  aggagagct  ctaaattgt  ttcttaata  acatttttc  1800
catttgtaa  aaaaaagga  ttc  1823



<210> 9106
<211> 534
<212> PRT
<213> Homo sapiens
<308> NP_003896
<400> 9106

Met Ala Gln Leu Gly Lys Leu Leu Lys Glu Gln Lys Tyr Asp Arg Gln 
  1               5                  10                  15
Leu Arg Leu Trp Gly Asp His Gly Gln Glu Ala Leu Glu Ser Ala His 
             20                  25                  30
Val Cys Leu Ile Asn Ala Thr Ala Thr Gly Thr Glu Ile Leu Lys Asn 
         35                  40                  45
Leu Val Leu Pro Gly Ile Gly Ser Phe Thr Ile Ile Asp Gly Asn Gln 
     50                  55                  60
Val Ser Gly Glu Asp Ala Gly Asn Asn Phe Phe Leu Gln Arg Ser Ser 
 65                  70                  75                  80
Ile Gly Lys Asn Arg Ala Glu Ala Ala Met Glu Phe Leu Gln Glu Leu 
                 85                  90                  95
Asn Ser Asp Val Ser Gly Ser Phe Val Glu Glu Ser Pro Glu Asn Leu 
             100                105                110
Leu Asp Asn Asp Pro Ser Phe Phe Cys Arg Phe Thr Val Val Val Ala 
         115                120                125
Thr Gln Leu Pro Glu Ser Thr Ser Leu Arg Leu Ala Asp Val Leu Trp 
     130                135                140
Asn Ser Gln Ile Pro Leu Leu Ile Cys Arg Thr Tyr Gly Leu Val Gly 
 145                150                155                160
Tyr Met Arg Ile Ile Ile Lys Glu His Pro Val Ile Glu Ser His Pro 
                 165                170                175
Asp Asn Ala Leu Glu Asp Leu Arg Leu Asp Lys Pro Phe Pro Glu Leu 
             180                185                190
Arg Glu His Phe Gln Ser Tyr Asp Leu Asp His Met Glu Lys Lys Asp 
         195                200                205
His Ser His Thr Pro Trp Ile Val Ile Ile Ala Lys Tyr Leu Ala Gln 
     210                215                220
Trp Tyr Ser Glu Thr Asn Gly Arg Ile Pro Lys Thr Tyr Lys Glu Lys 
 225                230                235                240
Glu Asp Phe Arg Asp Leu Ile Arg Gln Gly Ile Leu Lys Asn Glu Asn 
                 245                250                255
Gly Ala Pro Glu Asp Glu Glu Asn Phe Glu Glu Ala Ile Lys Asn Val 
             260                265                270
Asn Thr Ala Leu Asn Thr Thr Gln Ile Pro Ser Ser Ile Glu Asp Ile 
         275                280                285
Phe Asn Asp Asp Arg Cys Ile Asn Ile Thr Lys Gln Thr Pro Ser Phe 
     290                295                300
Trp Ile Leu Ala Arg Ala Leu Lys Glu Phe Val Ala Lys Glu Gly Gln 
 305                310                315                320
Gly Asn Leu Pro Val Arg Gly Thr Ile Pro Asp Met Ile Ala Asp Ser 
                 325                330                335
Gly Lys Tyr Ile Lys Leu Gln Asn Val Tyr Arg Glu Lys Ala Lys Lys 
             340                345                350
Asp Ala Ala Ala Val Gly Asn His Val Ala Lys Leu Leu Gln Ser Ile 
         355                360                365
Gly Gln Ala Pro Glu Ser Ile Ser Glu Lys Glu Leu Lys Leu Leu Cys 
     370                375                380
Ser Asn Ser Ala Phe Leu Arg Val Val Arg Cys Arg Ser Leu Ala Glu 
 385                390                395                400
Glu Tyr Gly Leu Asp Thr Ile Asn Lys Asp Glu Ile Ile Ser Ser Met 
                 405                410                415
Asp Asn Pro Asp Asn Glu Ile Val Leu Tyr Leu Met Leu Arg Ala Val 
             420                425                430
Asp Arg Phe His Lys Gln Gln Gly Arg Tyr Pro Gly Val Ser Asn Tyr 
         435                440                445
Gln Val Glu Glu Asp Ile Gly Lys Leu Lys Ser Cys Leu Thr Gly Phe 
     450                455                460
Leu Gln Glu Tyr Gly Leu Ser Val Met Val Lys Asp Asp Tyr Val His 
 465                470                475                480
Glu Phe Cys Arg Tyr Gly Ala Ala Glu Pro His Thr Ile Ala Ala Phe 
                 485                490                495
Leu Gly Gly Ala Ala Ala Gln Glu Val Ile Lys Ile Ile Thr Lys Gln 
             500                505                510
Phe Val Ile Phe Asn Asn Thr Tyr Ile Tyr Ser Gly Met Ser Gln Thr 
         515                520                525
Ser Ala Thr Phe Gln Leu 
     530



<210> 9107
<211> 1686
<212> DNA
<213> Rattus norvegicus
<308> U91561
<400> 9107

cctaagttg  ttgtctggg  cactggcaa  ttcttcctt  ccaggctag  cacacaggc  60
gagcaattg  ttccgaacc  agaggaacc  aggcgacgc  aggtcacgt  gccgactgc  120
tacatgacc  gcgggctgc  gagcgtcac  gtgacgttc  ggagacctg  gaagtggcc  180
ggctacttc  gtcacctgt  ctgtcgggg  gctgtcatg  acctgggac  gatgcgcaa  240
agttaccgc  gggaccgag  ggcatttga  gaggctcat  tgacctctc  ggatcccat  300
aagcagttt  cttcctggt  cgaggaggc  gttcaatgt  cagatatag  agaagccaa  360
gctatgtgt  tggctacct  caccagaga  ggaaaaccc  ctgcccgca  gctgctgct  420
aagggcttt  gcaaggatg  cttccgctt  ttcactaac  acgagagtc  gaaggggaa  480
gagctggac  ctaacccct  tgcctctct  gtcttctat  gggagcccc  gaaccgtca  540
gtgcgtgtg  aaggcccag  gaagaaact  ccggagaag  aggctgaga  ctacttcca  600
tcccggccc  agagcagcc  gattggggc  gtggtcagt  gccagagtt  tgtgatccc  660
gatcgggag  acctgagaa  gaaaaatga  gaactgggg  agctctacc  ggaacaaga  720
gtgcccaag  cagagtact  gggtggcta  atcctatat  cccaagtga  ggagttctg  780
caaggccaa  ccaaccgcc  gcatgaccg  attgtcttc  gtcgaggcc  ggcaacagg  840
gactcccct  tgggaccca  gacccacca  ggggaggaa  actgggtgt  tgagagact  900
gcaccttga  actggactc  agaatgttg  gggatcatc  tagggaaga  tgggggaag  960
gaaggaaaa  aatggaagc  aggtatacc  tctgtgtgt  tgtgtgtat  tgagacatt  1020
ggtttaaac  tcgctcaca  taggtaaca  tttaccact  agataaagt  ccagcattt  1080
ttcttacta  cttttattt  aagactaag  tgcttagtc  ggccctgaa  tcactgtgt  1140
tacatccca  acaagtctt  gctttgagt  cctcccctc  gtcccttga  tagcagtat  1200
ataggcttg  gccaccagg  ccagttcta  tcctgtttt  aagaagccc  ttgcctttg  1260
ttttttttt  ttttttttt  ttcggggct  gggactgaa  ccaggacct  cggcttcct  1320
ggcaagcgc  ctaccactg  gccaaatcc  caacccgcc  attgccttt  cctttgtta  1380
cccttctac  tgcatttct  caggactca  cctcaagtt  tctgaactc  ggatcggtt  1440
agtggctgg  acagagcgc  gtagtgttg  agagagtca  aagtagcaa  gagtctcat  1500
attattccc  tgattttgc  cctggtttg  ggggacgcc  gtcttggga  ctgcagctg  1560
tctaactct  tttccagta  cagactaat  aggccgcag  tatacaagg  ctcgctggc  1620
atggaaagg  gccagacca  gtttgctgt  actcagaca  accattata  gttctggtt  1680
gccttg  1686



<210> 9108
<211> 261
<212> PRT
<213> Rattus norvegicus
<308> AAC23707
<400> 9108

Met Thr Cys Gly Leu Leu Ser Val Thr Val Thr Phe Arg Arg Pro Ala 
  1               5                  10                  15
Lys Trp Pro Gly Tyr Phe Arg His Leu Cys Cys Arg Gly Ala Val Met 
             20                  25                  30
Asp Leu Gly Pro Met Arg Lys Ser Tyr Arg Gly Asp Arg Glu Ala Phe 
         35                  40                  45
Glu Glu Ala His Leu Thr Ser Leu Asp Pro Met Lys Gln Phe Ala Ser 
     50                  55                  60
Trp Phe Glu Glu Ala Val Gln Cys Pro Asp Ile Gly Glu Ala Asn Ala 
 65                  70                  75                  80
Met Cys Leu Ala Thr Cys Thr Arg Asp Gly Lys Pro Ser Ala Arg Met 
                 85                  90                  95
Leu Leu Leu Lys Gly Phe Gly Lys Asp Gly Phe Arg Phe Phe Thr Asn 
             100                105                110
Tyr Glu Ser Arg Lys Gly Lys Glu Leu Asp Ser Asn Pro Phe Ala Ser 
         115                120                125
Leu Val Phe Tyr Trp Glu Pro Leu Asn Arg Gln Val Arg Val Glu Gly 
     130                135                140
Pro Val Lys Lys Leu Pro Glu Lys Glu Ala Glu Asn Tyr Phe His Ser 
 145                150                155                160
Arg Pro Lys Ser Ser Gln Ile Gly Ala Val Val Ser Arg Gln Ser Ser 
                 165                170                175
Val Ile Pro Asp Arg Glu Tyr Leu Arg Lys Lys Asn Glu Glu Leu Gly 
             180                185                190
Gln Leu Tyr Arg Glu Gln Glu Val Pro Lys Pro Glu Tyr Trp Gly Gly 
         195                200                205
Tyr Ile Leu Tyr Pro Gln Val Met Glu Phe Trp Gln Gly Gln Thr Asn 
     210                215                220
Arg Leu His Asp Arg Ile Val Phe Arg Arg Gly Leu Ala Thr Gly Asp 
 225                230                235                240
Ser Pro Leu Gly Pro Met Thr His His Gly Glu Glu Asp Trp Val Tyr 
                 245                250                255
Glu Arg Leu Ala Pro 
             260



<210> 9109
<211> 2396
<212> DNA
<213> Homo sapiens
<308> NM_018129
<400> 9109

aaatccttc  ttccccggg  tagaagtcc  gggtgagaa  ttggttccg  actcaaagg  60
acccagtgc  gggccacag  cgggtcacg  ggccggcgg  cccccatga  gtgctggct  120
cggggcgtc  cggcgacgt  cgggcgacc  gccgagtgg  caggctacc  cagtcacct  180
tgtggtcgc  gtgctgcca  ggacctggg  cccatgcgc  agagttacc  cggggaccg  240
gaggcattt  aggagactc  tctgacctc  cttgaccca  tgaaacagt  tgctgcctg  300
tttgaggag  ctgttcagt  tcctgacat  ggggaagcc  atgccatgt  tctggctac  360
tgcaccaga  atggaaaac  ctctgctcg  atgttgctg  tgaagggct  cgggaaaga  420
ggcttccgc  tcttcacta  cttcgagag  cgaaaagga  aagagctgg  ctctaatcc  480
tttgcttcc  ttgtcttct  ctgggagcc  cttaaccgt  aggtgcgtg  ggaaggccc  540
gtgaagaaa  tgcctgagg  ggaggctga  tgctacttc  actcccgcc  caagagcag  600
cagattggg  ctgtggtca  ccaccagag  tctgtgatc  ctgatcggg  gtatctgag  660
aagaaaaat  aggaactgg  acagctcta  caggatcaa  aggtgccca  gccaaaatc  720
tggggtggc  atgtcctgt  ccctcaggt  atggagttc  ggcaaggtc  aaccaaccg  780
ctgcatgac  ggatagtct  tcggcgggg  ctacccaca  gagattccc  tttggggcc  840
atgacccac  gcggggagg  agactggct  tatgagaga  ttgcacctt  actctggga  900
ctgctggcc  agagtggag  tagggctag  tgtcaagag  gggtgtggg  ttgggaccc  960
ggcccttct  tctaaactc  acccatttc  ctccctacc  cttatcttc  ggactcttc  1020
gagctaatc  tctaagttc  ctgtactca  ttggttctc  gttagctgg  taagtggag  1080
gtaatggtg  cgtagagaa  cacaaatgg  aaataattc  ataattatt  ttttgacct  1140
gcctatgat  gattaggat  gctccctct  ggggtagca  ccggtgtga  tccctttct  1200
gtgacagac  gggccccag  agccctgtc  gttaccatg  gagtcatac  ggccaaagc  1260
tagtcctag  atatgcacc  gagccaacc  ggccaatca  attgttttg  caataattt  1320
aaatttgaa  tggagagat  cagaacctt  ggagtcatt  aagccaagt  attcatagc  1380
gccaggaaa  aataggaac  aaaagcctc  gcctgctgc  attgcaatt  ccaggatct  1440
tccttccct  gatccctcc  tcccaggtc  gggctgtgc  gttcctccc  ctgccttaa  1500
acaccccac  atctctgta  agtctctct  tctcttttt  tttttttac  taatctagc  1560
agaatctat  tctgttgat  acaacttaa  taactcatt  acggatagg  ctttttttt  1620
ttctttttt  cttttttct  ttctttttt  ttttgagat  gagtctcac  ctgtcaccc  1680
ggctggagt  cagtggtgt  atcttggct  actgcaacc  ctgcctccc  ggttcaagc  1740
attctcctg  ctcagcctc  caagtagct  ggactacag  cacacgcca  cacacccaa  1800
taatttttg  atttttagt  gagatgggg  ttcaccatg  tggccagga  tgtctccat  1860
tcttgacct  gtgatccac  cacctcagc  tcccaaagt  ctgggatta  aggcatgag  1920
caccacacc  agcgagacg  ggtttcatt  tgttggcca  gctggtctc  aactcctga  1980
ctaaagtga  ctgcccgcc  tggcctccc  aagtgctgg  attacagac  tgagccacc  2040
cgcttggcc  ggatagtat  tttttatag  acttcccct  ctgattgct  ccttctctg  2100
ggctacaag  gacccacag  attacaggg  agttacagg  aagcaggtt  catctcaat  2160
ttgggaggg  tttcaaaca  tcacacctg  ctgagaagg  gtgggctgt  actaggaat  2220
tttattccc  gtccgtcag  aattttgta  aagggcttc  tgtgctggt  ccaatagga  2280
aggaagatt  taatcagct  tactatcta  gttttttta  ggaaactgt  tgtatgtat  2340
catacattt  ccaaaaaga  aaattaaat  attatagag  ttatgtttt  cagact  2396



<210> 9110
<211> 261
<212> PRT
<213> Homo sapiens
<308> NP_060599
<400> 9110

Met Thr Cys Trp Leu Arg Gly Val Thr Ala Thr Phe Gly Arg Pro Ala 
  1               5                  10                  15
Glu Trp Pro Gly Tyr Leu Ser His Leu Cys Gly Arg Ser Ala Ala Met 
             20                  25                  30
Asp Leu Gly Pro Met Arg Lys Ser Tyr Arg Gly Asp Arg Glu Ala Phe 
         35                  40                  45
Glu Glu Thr His Leu Thr Ser Leu Asp Pro Val Lys Gln Phe Ala Ala 
     50                  55                  60
Trp Phe Glu Glu Ala Val Gln Cys Pro Asp Ile Gly Glu Ala Asn Ala 
 65                  70                  75                  80
Met Cys Leu Ala Thr Cys Thr Arg Asp Gly Lys Pro Ser Ala Arg Met 
                 85                  90                  95
Leu Leu Leu Lys Gly Phe Gly Lys Asp Gly Phe Arg Phe Phe Thr Asn 
             100                105                110
Phe Glu Ser Arg Lys Gly Lys Glu Leu Asp Ser Asn Pro Phe Ala Ser 
         115                120                125
Leu Val Phe Tyr Trp Glu Pro Leu Asn Arg Gln Val Arg Val Glu Gly 
     130                135                140
Pro Val Lys Lys Leu Pro Glu Glu Glu Ala Glu Cys Tyr Phe His Ser 
 145                150                155                160
Arg Pro Lys Ser Ser Gln Ile Gly Ala Val Val Ser His Gln Ser Ser 
                 165                170                175
Val Ile Pro Asp Arg Glu Tyr Leu Arg Lys Lys Asn Glu Glu Leu Glu 
             180                185                190
Gln Leu Tyr Gln Asp Gln Glu Val Pro Lys Pro Lys Ser Trp Gly Gly 
         195                200                205
Tyr Val Leu Tyr Pro Gln Val Met Glu Phe Trp Gln Gly Gln Thr Asn 
     210                215                220
Arg Leu His Asp Arg Ile Val Phe Arg Arg Gly Leu Pro Thr Gly Asp 
 225                230                235                240
Ser Pro Leu Gly Pro Met Thr His Arg Gly Glu Glu Asp Trp Leu Tyr 
                 245                250                255
Glu Arg Leu Ala Pro 
             260



<210> 9111
<211> 1686
<212> DNA
<213> Rattus norvegicus
<308> U91561
<400> 9111

cctaagttg  ttgtctggg  cactggcaa  ttcttcctt  ccaggctag  cacacaggc  60
gagcaattg  ttccgaacc  agaggaacc  aggcgacgc  aggtcacgt  gccgactgc  120
tacatgacc  gcgggctgc  gagcgtcac  gtgacgttc  ggagacctg  gaagtggcc  180
ggctacttc  gtcacctgt  ctgtcgggg  gctgtcatg  acctgggac  gatgcgcaa  240
agttaccgc  gggaccgag  ggcatttga  gaggctcat  tgacctctc  ggatcccat  300
aagcagttt  cttcctggt  cgaggaggc  gttcaatgt  cagatatag  agaagccaa  360
gctatgtgt  tggctacct  caccagaga  ggaaaaccc  ctgcccgca  gctgctgct  420
aagggcttt  gcaaggatg  cttccgctt  ttcactaac  acgagagtc  gaaggggaa  480
gagctggac  ctaacccct  tgcctctct  gtcttctat  gggagcccc  gaaccgtca  540
gtgcgtgtg  aaggcccag  gaagaaact  ccggagaag  aggctgaga  ctacttcca  600
tcccggccc  agagcagcc  gattggggc  gtggtcagt  gccagagtt  tgtgatccc  660
gatcgggag  acctgagaa  gaaaaatga  gaactgggg  agctctacc  ggaacaaga  720
gtgcccaag  cagagtact  gggtggcta  atcctatat  cccaagtga  ggagttctg  780
caaggccaa  ccaaccgcc  gcatgaccg  attgtcttc  gtcgaggcc  ggcaacagg  840
gactcccct  tgggaccca  gacccacca  ggggaggaa  actgggtgt  tgagagact  900
gcaccttga  actggactc  agaatgttg  gggatcatc  tagggaaga  tgggggaag  960
gaaggaaaa  aatggaagc  aggtatacc  tctgtgtgt  tgtgtgtat  tgagacatt  1020
ggtttaaac  tcgctcaca  taggtaaca  tttaccact  agataaagt  ccagcattt  1080
ttcttacta  cttttattt  aagactaag  tgcttagtc  ggccctgaa  tcactgtgt  1140
tacatccca  acaagtctt  gctttgagt  cctcccctc  gtcccttga  tagcagtat  1200
ataggcttg  gccaccagg  ccagttcta  tcctgtttt  aagaagccc  ttgcctttg  1260
ttttttttt  ttttttttt  ttcggggct  gggactgaa  ccaggacct  cggcttcct  1320
ggcaagcgc  ctaccactg  gccaaatcc  caacccgcc  attgccttt  cctttgtta  1380
cccttctac  tgcatttct  caggactca  cctcaagtt  tctgaactc  ggatcggtt  1440
agtggctgg  acagagcgc  gtagtgttg  agagagtca  aagtagcaa  gagtctcat  1500
attattccc  tgattttgc  cctggtttg  ggggacgcc  gtcttggga  ctgcagctg  1560
tctaactct  tttccagta  cagactaat  aggccgcag  tatacaagg  ctcgctggc  1620
atggaaagg  gccagacca  gtttgctgt  actcagaca  accattata  gttctggtt  1680
gccttg  1686



<210> 9112
<211> 261
<212> PRT
<213> Rattus norvegicus
<308> AAC23707
<400> 9112

Met Thr Cys Gly Leu Leu Ser Val Thr Val Thr Phe Arg Arg Pro Ala 
  1               5                  10                  15
Lys Trp Pro Gly Tyr Phe Arg His Leu Cys Cys Arg Gly Ala Val Met 
             20                  25                  30
Asp Leu Gly Pro Met Arg Lys Ser Tyr Arg Gly Asp Arg Glu Ala Phe 
         35                  40                  45
Glu Glu Ala His Leu Thr Ser Leu Asp Pro Met Lys Gln Phe Ala Ser 
     50                  55                  60
Trp Phe Glu Glu Ala Val Gln Cys Pro Asp Ile Gly Glu Ala Asn Ala 
 65                  70                  75                  80
Met Cys Leu Ala Thr Cys Thr Arg Asp Gly Lys Pro Ser Ala Arg Met 
                 85                  90                  95
Leu Leu Leu Lys Gly Phe Gly Lys Asp Gly Phe Arg Phe Phe Thr Asn 
             100                105                110
Tyr Glu Ser Arg Lys Gly Lys Glu Leu Asp Ser Asn Pro Phe Ala Ser 
         115                120                125
Leu Val Phe Tyr Trp Glu Pro Leu Asn Arg Gln Val Arg Val Glu Gly 
     130                135                140
Pro Val Lys Lys Leu Pro Glu Lys Glu Ala Glu Asn Tyr Phe His Ser 
 145                150                155                160
Arg Pro Lys Ser Ser Gln Ile Gly Ala Val Val Ser Arg Gln Ser Ser 
                 165                170                175
Val Ile Pro Asp Arg Glu Tyr Leu Arg Lys Lys Asn Glu Glu Leu Gly 
             180                185                190
Gln Leu Tyr Arg Glu Gln Glu Val Pro Lys Pro Glu Tyr Trp Gly Gly 
         195                200                205
Tyr Ile Leu Tyr Pro Gln Val Met Glu Phe Trp Gln Gly Gln Thr Asn 
     210                215                220
Arg Leu His Asp Arg Ile Val Phe Arg Arg Gly Leu Ala Thr Gly Asp 
 225                230                235                240
Ser Pro Leu Gly Pro Met Thr His His Gly Glu Glu Asp Trp Val Tyr 
                 245                250                255
Glu Arg Leu Ala Pro 
             260



<210> 9113
<211> 2396
<212> DNA
<213> Homo sapiens
<308> NM_018129
<400> 9113

aaatccttc  ttccccggg  tagaagtcc  gggtgagaa  ttggttccg  actcaaagg  60
acccagtgc  gggccacag  cgggtcacg  ggccggcgg  cccccatga  gtgctggct  120
cggggcgtc  cggcgacgt  cgggcgacc  gccgagtgg  caggctacc  cagtcacct  180
tgtggtcgc  gtgctgcca  ggacctggg  cccatgcgc  agagttacc  cggggaccg  240
gaggcattt  aggagactc  tctgacctc  cttgaccca  tgaaacagt  tgctgcctg  300
tttgaggag  ctgttcagt  tcctgacat  ggggaagcc  atgccatgt  tctggctac  360
tgcaccaga  atggaaaac  ctctgctcg  atgttgctg  tgaagggct  cgggaaaga  420
ggcttccgc  tcttcacta  cttcgagag  cgaaaagga  aagagctgg  ctctaatcc  480
tttgcttcc  ttgtcttct  ctgggagcc  cttaaccgt  aggtgcgtg  ggaaggccc  540
gtgaagaaa  tgcctgagg  ggaggctga  tgctacttc  actcccgcc  caagagcag  600
cagattggg  ctgtggtca  ccaccagag  tctgtgatc  ctgatcggg  gtatctgag  660
aagaaaaat  aggaactgg  acagctcta  caggatcaa  aggtgccca  gccaaaatc  720
tggggtggc  atgtcctgt  ccctcaggt  atggagttc  ggcaaggtc  aaccaaccg  780
ctgcatgac  ggatagtct  tcggcgggg  ctacccaca  gagattccc  tttggggcc  840
atgacccac  gcggggagg  agactggct  tatgagaga  ttgcacctt  actctggga  900
ctgctggcc  agagtggag  tagggctag  tgtcaagag  gggtgtggg  ttgggaccc  960
ggcccttct  tctaaactc  acccatttc  ctccctacc  cttatcttc  ggactcttc  1020
gagctaatc  tctaagttc  ctgtactca  ttggttctc  gttagctgg  taagtggag  1080
gtaatggtg  cgtagagaa  cacaaatgg  aaataattc  ataattatt  ttttgacct  1140
gcctatgat  gattaggat  gctccctct  ggggtagca  ccggtgtga  tccctttct  1200
gtgacagac  gggccccag  agccctgtc  gttaccatg  gagtcatac  ggccaaagc  1260
tagtcctag  atatgcacc  gagccaacc  ggccaatca  attgttttg  caataattt  1320
aaatttgaa  tggagagat  cagaacctt  ggagtcatt  aagccaagt  attcatagc  1380
gccaggaaa  aataggaac  aaaagcctc  gcctgctgc  attgcaatt  ccaggatct  1440
tccttccct  gatccctcc  tcccaggtc  gggctgtgc  gttcctccc  ctgccttaa  1500
acaccccac  atctctgta  agtctctct  tctcttttt  tttttttac  taatctagc  1560
agaatctat  tctgttgat  acaacttaa  taactcatt  acggatagg  ctttttttt  1620
ttctttttt  cttttttct  ttctttttt  ttttgagat  gagtctcac  ctgtcaccc  1680
ggctggagt  cagtggtgt  atcttggct  actgcaacc  ctgcctccc  ggttcaagc  1740
attctcctg  ctcagcctc  caagtagct  ggactacag  cacacgcca  cacacccaa  1800
taatttttg  atttttagt  gagatgggg  ttcaccatg  tggccagga  tgtctccat  1860
tcttgacct  gtgatccac  cacctcagc  tcccaaagt  ctgggatta  aggcatgag  1920
caccacacc  agcgagacg  ggtttcatt  tgttggcca  gctggtctc  aactcctga  1980
ctaaagtga  ctgcccgcc  tggcctccc  aagtgctgg  attacagac  tgagccacc  2040
cgcttggcc  ggatagtat  tttttatag  acttcccct  ctgattgct  ccttctctg  2100
ggctacaag  gacccacag  attacaggg  agttacagg  aagcaggtt  catctcaat  2160
ttgggaggg  tttcaaaca  tcacacctg  ctgagaagg  gtgggctgt  actaggaat  2220
tttattccc  gtccgtcag  aattttgta  aagggcttc  tgtgctggt  ccaatagga  2280
aggaagatt  taatcagct  tactatcta  gttttttta  ggaaactgt  tgtatgtat  2340
catacattt  ccaaaaaga  aaattaaat  attatagag  ttatgtttt  cagact  2396



<210> 9114
<211> 261
<212> PRT
<213> Homo sapiens
<308> NP_060599
<400> 9114

Met Thr Cys Trp Leu Arg Gly Val Thr Ala Thr Phe Gly Arg Pro Ala 
  1               5                  10                  15
Glu Trp Pro Gly Tyr Leu Ser His Leu Cys Gly Arg Ser Ala Ala Met 
             20                  25                  30
Asp Leu Gly Pro Met Arg Lys Ser Tyr Arg Gly Asp Arg Glu Ala Phe 
         35                  40                  45
Glu Glu Thr His Leu Thr Ser Leu Asp Pro Val Lys Gln Phe Ala Ala 
     50                  55                  60
Trp Phe Glu Glu Ala Val Gln Cys Pro Asp Ile Gly Glu Ala Asn Ala 
 65                  70                  75                  80
Met Cys Leu Ala Thr Cys Thr Arg Asp Gly Lys Pro Ser Ala Arg Met 
                 85                  90                  95
Leu Leu Leu Lys Gly Phe Gly Lys Asp Gly Phe Arg Phe Phe Thr Asn 
             100                105                110
Phe Glu Ser Arg Lys Gly Lys Glu Leu Asp Ser Asn Pro Phe Ala Ser 
         115                120                125
Leu Val Phe Tyr Trp Glu Pro Leu Asn Arg Gln Val Arg Val Glu Gly 
     130                135                140
Pro Val Lys Lys Leu Pro Glu Glu Glu Ala Glu Cys Tyr Phe His Ser 
 145                150                155                160
Arg Pro Lys Ser Ser Gln Ile Gly Ala Val Val Ser His Gln Ser Ser 
                 165                170                175
Val Ile Pro Asp Arg Glu Tyr Leu Arg Lys Lys Asn Glu Glu Leu Glu 
             180                185                190
Gln Leu Tyr Gln Asp Gln Glu Val Pro Lys Pro Lys Ser Trp Gly Gly 
         195                200                205
Tyr Val Leu Tyr Pro Gln Val Met Glu Phe Trp Gln Gly Gln Thr Asn 
     210                215                220
Arg Leu His Asp Arg Ile Val Phe Arg Arg Gly Leu Pro Thr Gly Asp 
 225                230                235                240
Ser Pro Leu Gly Pro Met Thr His Arg Gly Glu Glu Asp Trp Leu Tyr 
                 245                250                255
Glu Arg Leu Ala Pro 
             260



<210> 9115
<211> 1686
<212> DNA
<213> Rattus norvegicus
<308> U91561
<400> 9115

cctaagttg  ttgtctggg  cactggcaa  ttcttcctt  ccaggctag  cacacaggc  60
gagcaattg  ttccgaacc  agaggaacc  aggcgacgc  aggtcacgt  gccgactgc  120
tacatgacc  gcgggctgc  gagcgtcac  gtgacgttc  ggagacctg  gaagtggcc  180
ggctacttc  gtcacctgt  ctgtcgggg  gctgtcatg  acctgggac  gatgcgcaa  240
agttaccgc  gggaccgag  ggcatttga  gaggctcat  tgacctctc  ggatcccat  300
aagcagttt  cttcctggt  cgaggaggc  gttcaatgt  cagatatag  agaagccaa  360
gctatgtgt  tggctacct  caccagaga  ggaaaaccc  ctgcccgca  gctgctgct  420
aagggcttt  gcaaggatg  cttccgctt  ttcactaac  acgagagtc  gaaggggaa  480
gagctggac  ctaacccct  tgcctctct  gtcttctat  gggagcccc  gaaccgtca  540
gtgcgtgtg  aaggcccag  gaagaaact  ccggagaag  aggctgaga  ctacttcca  600
tcccggccc  agagcagcc  gattggggc  gtggtcagt  gccagagtt  tgtgatccc  660
gatcgggag  acctgagaa  gaaaaatga  gaactgggg  agctctacc  ggaacaaga  720
gtgcccaag  cagagtact  gggtggcta  atcctatat  cccaagtga  ggagttctg  780
caaggccaa  ccaaccgcc  gcatgaccg  attgtcttc  gtcgaggcc  ggcaacagg  840
gactcccct  tgggaccca  gacccacca  ggggaggaa  actgggtgt  tgagagact  900
gcaccttga  actggactc  agaatgttg  gggatcatc  tagggaaga  tgggggaag  960
gaaggaaaa  aatggaagc  aggtatacc  tctgtgtgt  tgtgtgtat  tgagacatt  1020
ggtttaaac  tcgctcaca  taggtaaca  tttaccact  agataaagt  ccagcattt  1080
ttcttacta  cttttattt  aagactaag  tgcttagtc  ggccctgaa  tcactgtgt  1140
tacatccca  acaagtctt  gctttgagt  cctcccctc  gtcccttga  tagcagtat  1200
ataggcttg  gccaccagg  ccagttcta  tcctgtttt  aagaagccc  ttgcctttg  1260
ttttttttt  ttttttttt  ttcggggct  gggactgaa  ccaggacct  cggcttcct  1320
ggcaagcgc  ctaccactg  gccaaatcc  caacccgcc  attgccttt  cctttgtta  1380
cccttctac  tgcatttct  caggactca  cctcaagtt  tctgaactc  ggatcggtt  1440
agtggctgg  acagagcgc  gtagtgttg  agagagtca  aagtagcaa  gagtctcat  1500
attattccc  tgattttgc  cctggtttg  ggggacgcc  gtcttggga  ctgcagctg  1560
tctaactct  tttccagta  cagactaat  aggccgcag  tatacaagg  ctcgctggc  1620
atggaaagg  gccagacca  gtttgctgt  actcagaca  accattata  gttctggtt  1680
gccttg  1686



<210> 9116
<211> 261
<212> PRT
<213> Rattus norvegicus
<308> AAC23707
<400> 9116

Met Thr Cys Gly Leu Leu Ser Val Thr Val Thr Phe Arg Arg Pro Ala 
  1               5                  10                  15
Lys Trp Pro Gly Tyr Phe Arg His Leu Cys Cys Arg Gly Ala Val Met 
             20                  25                  30
Asp Leu Gly Pro Met Arg Lys Ser Tyr Arg Gly Asp Arg Glu Ala Phe 
         35                  40                  45
Glu Glu Ala His Leu Thr Ser Leu Asp Pro Met Lys Gln Phe Ala Ser 
     50                  55                  60
Trp Phe Glu Glu Ala Val Gln Cys Pro Asp Ile Gly Glu Ala Asn Ala 
 65                  70                  75                  80
Met Cys Leu Ala Thr Cys Thr Arg Asp Gly Lys Pro Ser Ala Arg Met 
                 85                  90                  95
Leu Leu Leu Lys Gly Phe Gly Lys Asp Gly Phe Arg Phe Phe Thr Asn 
             100                105                110
Tyr Glu Ser Arg Lys Gly Lys Glu Leu Asp Ser Asn Pro Phe Ala Ser 
         115                120                125
Leu Val Phe Tyr Trp Glu Pro Leu Asn Arg Gln Val Arg Val Glu Gly 
     130                135                140
Pro Val Lys Lys Leu Pro Glu Lys Glu Ala Glu Asn Tyr Phe His Ser 
 145                150                155                160
Arg Pro Lys Ser Ser Gln Ile Gly Ala Val Val Ser Arg Gln Ser Ser 
                 165                170                175
Val Ile Pro Asp Arg Glu Tyr Leu Arg Lys Lys Asn Glu Glu Leu Gly 
             180                185                190
Gln Leu Tyr Arg Glu Gln Glu Val Pro Lys Pro Glu Tyr Trp Gly Gly 
         195                200                205
Tyr Ile Leu Tyr Pro Gln Val Met Glu Phe Trp Gln Gly Gln Thr Asn 
     210                215                220
Arg Leu His Asp Arg Ile Val Phe Arg Arg Gly Leu Ala Thr Gly Asp 
 225                230                235                240
Ser Pro Leu Gly Pro Met Thr His His Gly Glu Glu Asp Trp Val Tyr 
                 245                250                255
Glu Arg Leu Ala Pro 
             260



<210> 9117
<211> 2396
<212> DNA
<213> Homo sapiens
<308> NM_018129
<400> 9117

aaatccttc  ttccccggg  tagaagtcc  gggtgagaa  ttggttccg  actcaaagg  60
acccagtgc  gggccacag  cgggtcacg  ggccggcgg  cccccatga  gtgctggct  120
cggggcgtc  cggcgacgt  cgggcgacc  gccgagtgg  caggctacc  cagtcacct  180
tgtggtcgc  gtgctgcca  ggacctggg  cccatgcgc  agagttacc  cggggaccg  240
gaggcattt  aggagactc  tctgacctc  cttgaccca  tgaaacagt  tgctgcctg  300
tttgaggag  ctgttcagt  tcctgacat  ggggaagcc  atgccatgt  tctggctac  360
tgcaccaga  atggaaaac  ctctgctcg  atgttgctg  tgaagggct  cgggaaaga  420
ggcttccgc  tcttcacta  cttcgagag  cgaaaagga  aagagctgg  ctctaatcc  480
tttgcttcc  ttgtcttct  ctgggagcc  cttaaccgt  aggtgcgtg  ggaaggccc  540
gtgaagaaa  tgcctgagg  ggaggctga  tgctacttc  actcccgcc  caagagcag  600
cagattggg  ctgtggtca  ccaccagag  tctgtgatc  ctgatcggg  gtatctgag  660
aagaaaaat  aggaactgg  acagctcta  caggatcaa  aggtgccca  gccaaaatc  720
tggggtggc  atgtcctgt  ccctcaggt  atggagttc  ggcaaggtc  aaccaaccg  780
ctgcatgac  ggatagtct  tcggcgggg  ctacccaca  gagattccc  tttggggcc  840
atgacccac  gcggggagg  agactggct  tatgagaga  ttgcacctt  actctggga  900
ctgctggcc  agagtggag  tagggctag  tgtcaagag  gggtgtggg  ttgggaccc  960
ggcccttct  tctaaactc  acccatttc  ctccctacc  cttatcttc  ggactcttc  1020
gagctaatc  tctaagttc  ctgtactca  ttggttctc  gttagctgg  taagtggag  1080
gtaatggtg  cgtagagaa  cacaaatgg  aaataattc  ataattatt  ttttgacct  1140
gcctatgat  gattaggat  gctccctct  ggggtagca  ccggtgtga  tccctttct  1200
gtgacagac  gggccccag  agccctgtc  gttaccatg  gagtcatac  ggccaaagc  1260
tagtcctag  atatgcacc  gagccaacc  ggccaatca  attgttttg  caataattt  1320
aaatttgaa  tggagagat  cagaacctt  ggagtcatt  aagccaagt  attcatagc  1380
gccaggaaa  aataggaac  aaaagcctc  gcctgctgc  attgcaatt  ccaggatct  1440
tccttccct  gatccctcc  tcccaggtc  gggctgtgc  gttcctccc  ctgccttaa  1500
acaccccac  atctctgta  agtctctct  tctcttttt  tttttttac  taatctagc  1560
agaatctat  tctgttgat  acaacttaa  taactcatt  acggatagg  ctttttttt  1620
ttctttttt  cttttttct  ttctttttt  ttttgagat  gagtctcac  ctgtcaccc  1680
ggctggagt  cagtggtgt  atcttggct  actgcaacc  ctgcctccc  ggttcaagc  1740
attctcctg  ctcagcctc  caagtagct  ggactacag  cacacgcca  cacacccaa  1800
taatttttg  atttttagt  gagatgggg  ttcaccatg  tggccagga  tgtctccat  1860
tcttgacct  gtgatccac  cacctcagc  tcccaaagt  ctgggatta  aggcatgag  1920
caccacacc  agcgagacg  ggtttcatt  tgttggcca  gctggtctc  aactcctga  1980
ctaaagtga  ctgcccgcc  tggcctccc  aagtgctgg  attacagac  tgagccacc  2040
cgcttggcc  ggatagtat  tttttatag  acttcccct  ctgattgct  ccttctctg  2100
ggctacaag  gacccacag  attacaggg  agttacagg  aagcaggtt  catctcaat  2160
ttgggaggg  tttcaaaca  tcacacctg  ctgagaagg  gtgggctgt  actaggaat  2220
tttattccc  gtccgtcag  aattttgta  aagggcttc  tgtgctggt  ccaatagga  2280
aggaagatt  taatcagct  tactatcta  gttttttta  ggaaactgt  tgtatgtat  2340
catacattt  ccaaaaaga  aaattaaat  attatagag  ttatgtttt  cagact  2396



<210> 9118
<211> 261
<212> PRT
<213> Homo sapiens
<308> NP_060599
<400> 9118

Met Thr Cys Trp Leu Arg Gly Val Thr Ala Thr Phe Gly Arg Pro Ala 
  1               5                  10                  15
Glu Trp Pro Gly Tyr Leu Ser His Leu Cys Gly Arg Ser Ala Ala Met 
             20                  25                  30
Asp Leu Gly Pro Met Arg Lys Ser Tyr Arg Gly Asp Arg Glu Ala Phe 
         35                  40                  45
Glu Glu Thr His Leu Thr Ser Leu Asp Pro Val Lys Gln Phe Ala Ala 
     50                  55                  60
Trp Phe Glu Glu Ala Val Gln Cys Pro Asp Ile Gly Glu Ala Asn Ala 
 65                  70                  75                  80
Met Cys Leu Ala Thr Cys Thr Arg Asp Gly Lys Pro Ser Ala Arg Met 
                 85                  90                  95
Leu Leu Leu Lys Gly Phe Gly Lys Asp Gly Phe Arg Phe Phe Thr Asn 
             100                105                110
Phe Glu Ser Arg Lys Gly Lys Glu Leu Asp Ser Asn Pro Phe Ala Ser 
         115                120                125
Leu Val Phe Tyr Trp Glu Pro Leu Asn Arg Gln Val Arg Val Glu Gly 
     130                135                140
Pro Val Lys Lys Leu Pro Glu Glu Glu Ala Glu Cys Tyr Phe His Ser 
 145                150                155                160
Arg Pro Lys Ser Ser Gln Ile Gly Ala Val Val Ser His Gln Ser Ser 
                 165                170                175
Val Ile Pro Asp Arg Glu Tyr Leu Arg Lys Lys Asn Glu Glu Leu Glu 
             180                185                190
Gln Leu Tyr Gln Asp Gln Glu Val Pro Lys Pro Lys Ser Trp Gly Gly 
         195                200                205
Tyr Val Leu Tyr Pro Gln Val Met Glu Phe Trp Gln Gly Gln Thr Asn 
     210                215                220
Arg Leu His Asp Arg Ile Val Phe Arg Arg Gly Leu Pro Thr Gly Asp 
 225                230                235                240
Ser Pro Leu Gly Pro Met Thr His Arg Gly Glu Glu Asp Trp Leu Tyr 
                 245                250                255
Glu Arg Leu Ala Pro 
             260



<210> 9119
<211> 1686
<212> DNA
<213> Rattus norvegicus
<308> U91561
<400> 9119

cctaagttg  ttgtctggg  cactggcaa  ttcttcctt  ccaggctag  cacacaggc  60
gagcaattg  ttccgaacc  agaggaacc  aggcgacgc  aggtcacgt  gccgactgc  120
tacatgacc  gcgggctgc  gagcgtcac  gtgacgttc  ggagacctg  gaagtggcc  180
ggctacttc  gtcacctgt  ctgtcgggg  gctgtcatg  acctgggac  gatgcgcaa  240
agttaccgc  gggaccgag  ggcatttga  gaggctcat  tgacctctc  ggatcccat  300
aagcagttt  cttcctggt  cgaggaggc  gttcaatgt  cagatatag  agaagccaa  360
gctatgtgt  tggctacct  caccagaga  ggaaaaccc  ctgcccgca  gctgctgct  420
aagggcttt  gcaaggatg  cttccgctt  ttcactaac  acgagagtc  gaaggggaa  480
gagctggac  ctaacccct  tgcctctct  gtcttctat  gggagcccc  gaaccgtca  540
gtgcgtgtg  aaggcccag  gaagaaact  ccggagaag  aggctgaga  ctacttcca  600
tcccggccc  agagcagcc  gattggggc  gtggtcagt  gccagagtt  tgtgatccc  660
gatcgggag  acctgagaa  gaaaaatga  gaactgggg  agctctacc  ggaacaaga  720
gtgcccaag  cagagtact  gggtggcta  atcctatat  cccaagtga  ggagttctg  780
caaggccaa  ccaaccgcc  gcatgaccg  attgtcttc  gtcgaggcc  ggcaacagg  840
gactcccct  tgggaccca  gacccacca  ggggaggaa  actgggtgt  tgagagact  900
gcaccttga  actggactc  agaatgttg  gggatcatc  tagggaaga  tgggggaag  960
gaaggaaaa  aatggaagc  aggtatacc  tctgtgtgt  tgtgtgtat  tgagacatt  1020
ggtttaaac  tcgctcaca  taggtaaca  tttaccact  agataaagt  ccagcattt  1080
ttcttacta  cttttattt  aagactaag  tgcttagtc  ggccctgaa  tcactgtgt  1140
tacatccca  acaagtctt  gctttgagt  cctcccctc  gtcccttga  tagcagtat  1200
ataggcttg  gccaccagg  ccagttcta  tcctgtttt  aagaagccc  ttgcctttg  1260
ttttttttt  ttttttttt  ttcggggct  gggactgaa  ccaggacct  cggcttcct  1320
ggcaagcgc  ctaccactg  gccaaatcc  caacccgcc  attgccttt  cctttgtta  1380
cccttctac  tgcatttct  caggactca  cctcaagtt  tctgaactc  ggatcggtt  1440
agtggctgg  acagagcgc  gtagtgttg  agagagtca  aagtagcaa  gagtctcat  1500
attattccc  tgattttgc  cctggtttg  ggggacgcc  gtcttggga  ctgcagctg  1560
tctaactct  tttccagta  cagactaat  aggccgcag  tatacaagg  ctcgctggc  1620
atggaaagg  gccagacca  gtttgctgt  actcagaca  accattata  gttctggtt  1680
gccttg  1686



<210> 9120
<211> 261
<212> PRT
<213> Rattus norvegicus
<308> AAC23707
<400> 9120

Met Thr Cys Gly Leu Leu Ser Val Thr Val Thr Phe Arg Arg Pro Ala 
  1               5                  10                  15
Lys Trp Pro Gly Tyr Phe Arg His Leu Cys Cys Arg Gly Ala Val Met 
             20                  25                  30
Asp Leu Gly Pro Met Arg Lys Ser Tyr Arg Gly Asp Arg Glu Ala Phe 
         35                  40                  45
Glu Glu Ala His Leu Thr Ser Leu Asp Pro Met Lys Gln Phe Ala Ser 
     50                  55                  60
Trp Phe Glu Glu Ala Val Gln Cys Pro Asp Ile Gly Glu Ala Asn Ala 
 65                  70                  75                  80
Met Cys Leu Ala Thr Cys Thr Arg Asp Gly Lys Pro Ser Ala Arg Met 
                 85                  90                  95
Leu Leu Leu Lys Gly Phe Gly Lys Asp Gly Phe Arg Phe Phe Thr Asn 
             100                105                110
Tyr Glu Ser Arg Lys Gly Lys Glu Leu Asp Ser Asn Pro Phe Ala Ser 
         115                120                125
Leu Val Phe Tyr Trp Glu Pro Leu Asn Arg Gln Val Arg Val Glu Gly 
     130                135                140
Pro Val Lys Lys Leu Pro Glu Lys Glu Ala Glu Asn Tyr Phe His Ser 
 145                150                155                160
Arg Pro Lys Ser Ser Gln Ile Gly Ala Val Val Ser Arg Gln Ser Ser 
                 165                170                175
Val Ile Pro Asp Arg Glu Tyr Leu Arg Lys Lys Asn Glu Glu Leu Gly 
             180                185                190
Gln Leu Tyr Arg Glu Gln Glu Val Pro Lys Pro Glu Tyr Trp Gly Gly 
         195                200                205
Tyr Ile Leu Tyr Pro Gln Val Met Glu Phe Trp Gln Gly Gln Thr Asn 
     210                215                220
Arg Leu His Asp Arg Ile Val Phe Arg Arg Gly Leu Ala Thr Gly Asp 
 225                230                235                240
Ser Pro Leu Gly Pro Met Thr His His Gly Glu Glu Asp Trp Val Tyr 
                 245                250                255
Glu Arg Leu Ala Pro 
             260



<210> 9121
<211> 2396
<212> DNA
<213> Homo sapiens
<308> NM_018129
<400> 9121

aaatccttc  ttccccggg  tagaagtcc  gggtgagaa  ttggttccg  actcaaagg  60
acccagtgc  gggccacag  cgggtcacg  ggccggcgg  cccccatga  gtgctggct  120
cggggcgtc  cggcgacgt  cgggcgacc  gccgagtgg  caggctacc  cagtcacct  180
tgtggtcgc  gtgctgcca  ggacctggg  cccatgcgc  agagttacc  cggggaccg  240
gaggcattt  aggagactc  tctgacctc  cttgaccca  tgaaacagt  tgctgcctg  300
tttgaggag  ctgttcagt  tcctgacat  ggggaagcc  atgccatgt  tctggctac  360
tgcaccaga  atggaaaac  ctctgctcg  atgttgctg  tgaagggct  cgggaaaga  420
ggcttccgc  tcttcacta  cttcgagag  cgaaaagga  aagagctgg  ctctaatcc  480
tttgcttcc  ttgtcttct  ctgggagcc  cttaaccgt  aggtgcgtg  ggaaggccc  540
gtgaagaaa  tgcctgagg  ggaggctga  tgctacttc  actcccgcc  caagagcag  600
cagattggg  ctgtggtca  ccaccagag  tctgtgatc  ctgatcggg  gtatctgag  660
aagaaaaat  aggaactgg  acagctcta  caggatcaa  aggtgccca  gccaaaatc  720
tggggtggc  atgtcctgt  ccctcaggt  atggagttc  ggcaaggtc  aaccaaccg  780
ctgcatgac  ggatagtct  tcggcgggg  ctacccaca  gagattccc  tttggggcc  840
atgacccac  gcggggagg  agactggct  tatgagaga  ttgcacctt  actctggga  900
ctgctggcc  agagtggag  tagggctag  tgtcaagag  gggtgtggg  ttgggaccc  960
ggcccttct  tctaaactc  acccatttc  ctccctacc  cttatcttc  ggactcttc  1020
gagctaatc  tctaagttc  ctgtactca  ttggttctc  gttagctgg  taagtggag  1080
gtaatggtg  cgtagagaa  cacaaatgg  aaataattc  ataattatt  ttttgacct  1140
gcctatgat  gattaggat  gctccctct  ggggtagca  ccggtgtga  tccctttct  1200
gtgacagac  gggccccag  agccctgtc  gttaccatg  gagtcatac  ggccaaagc  1260
tagtcctag  atatgcacc  gagccaacc  ggccaatca  attgttttg  caataattt  1320
aaatttgaa  tggagagat  cagaacctt  ggagtcatt  aagccaagt  attcatagc  1380
gccaggaaa  aataggaac  aaaagcctc  gcctgctgc  attgcaatt  ccaggatct  1440
tccttccct  gatccctcc  tcccaggtc  gggctgtgc  gttcctccc  ctgccttaa  1500
acaccccac  atctctgta  agtctctct  tctcttttt  tttttttac  taatctagc  1560
agaatctat  tctgttgat  acaacttaa  taactcatt  acggatagg  ctttttttt  1620
ttctttttt  cttttttct  ttctttttt  ttttgagat  gagtctcac  ctgtcaccc  1680
ggctggagt  cagtggtgt  atcttggct  actgcaacc  ctgcctccc  ggttcaagc  1740
attctcctg  ctcagcctc  caagtagct  ggactacag  cacacgcca  cacacccaa  1800
taatttttg  atttttagt  gagatgggg  ttcaccatg  tggccagga  tgtctccat  1860
tcttgacct  gtgatccac  cacctcagc  tcccaaagt  ctgggatta  aggcatgag  1920
caccacacc  agcgagacg  ggtttcatt  tgttggcca  gctggtctc  aactcctga  1980
ctaaagtga  ctgcccgcc  tggcctccc  aagtgctgg  attacagac  tgagccacc  2040
cgcttggcc  ggatagtat  tttttatag  acttcccct  ctgattgct  ccttctctg  2100
ggctacaag  gacccacag  attacaggg  agttacagg  aagcaggtt  catctcaat  2160
ttgggaggg  tttcaaaca  tcacacctg  ctgagaagg  gtgggctgt  actaggaat  2220
tttattccc  gtccgtcag  aattttgta  aagggcttc  tgtgctggt  ccaatagga  2280
aggaagatt  taatcagct  tactatcta  gttttttta  ggaaactgt  tgtatgtat  2340
catacattt  ccaaaaaga  aaattaaat  attatagag  ttatgtttt  cagact  2396



<210> 9122
<211> 261
<212> PRT
<213> Homo sapiens
<308> NP_060599
<400> 9122

Met Thr Cys Trp Leu Arg Gly Val Thr Ala Thr Phe Gly Arg Pro Ala 
  1               5                  10                  15
Glu Trp Pro Gly Tyr Leu Ser His Leu Cys Gly Arg Ser Ala Ala Met 
             20                  25                  30
Asp Leu Gly Pro Met Arg Lys Ser Tyr Arg Gly Asp Arg Glu Ala Phe 
         35                  40                  45
Glu Glu Thr His Leu Thr Ser Leu Asp Pro Val Lys Gln Phe Ala Ala 
     50                  55                  60
Trp Phe Glu Glu Ala Val Gln Cys Pro Asp Ile Gly Glu Ala Asn Ala 
 65                  70                  75                  80
Met Cys Leu Ala Thr Cys Thr Arg Asp Gly Lys Pro Ser Ala Arg Met 
                 85                  90                  95
Leu Leu Leu Lys Gly Phe Gly Lys Asp Gly Phe Arg Phe Phe Thr Asn 
             100                105                110
Phe Glu Ser Arg Lys Gly Lys Glu Leu Asp Ser Asn Pro Phe Ala Ser 
         115                120                125
Leu Val Phe Tyr Trp Glu Pro Leu Asn Arg Gln Val Arg Val Glu Gly 
     130                135                140
Pro Val Lys Lys Leu Pro Glu Glu Glu Ala Glu Cys Tyr Phe His Ser 
 145                150                155                160
Arg Pro Lys Ser Ser Gln Ile Gly Ala Val Val Ser His Gln Ser Ser 
                 165                170                175
Val Ile Pro Asp Arg Glu Tyr Leu Arg Lys Lys Asn Glu Glu Leu Glu 
             180                185                190
Gln Leu Tyr Gln Asp Gln Glu Val Pro Lys Pro Lys Ser Trp Gly Gly 
         195                200                205
Tyr Val Leu Tyr Pro Gln Val Met Glu Phe Trp Gln Gly Gln Thr Asn 
     210                215                220
Arg Leu His Asp Arg Ile Val Phe Arg Arg Gly Leu Pro Thr Gly Asp 
 225                230                235                240
Ser Pro Leu Gly Pro Met Thr His Arg Gly Glu Glu Asp Trp Leu Tyr 
                 245                250                255
Glu Arg Leu Ala Pro 
             260



<210> 9124
<211> 1116
<212> PRT
<213> Rattus norvegicus
<308> AAD04756
<400> 9124

Met Arg Lys Phe Asn Ile Arg Lys Val Leu Asp Gly Leu Thr Ala Gly 
  1               5                  10                  15
Ser Ser Ser Ala Ser Gln Gln Gln Gln Gln Gln Gln His Pro Pro Gly 
             20                  25                  30
Asn Arg Glu Pro Glu Ile Gln Glu Thr Leu Gln Ser Glu His Phe Gln 
         35                  40                  45
Leu Cys Lys Thr Val Arg His Gly Phe Pro Tyr Gln Pro Ser Ala Leu 
     50                  55                  60
Ala Phe Asp Pro Val Gln Lys Ile Leu Ala Val Gly Thr Gln Thr Gly 
 65                  70                  75                  80
Ala Leu Arg Leu Phe Gly Arg Pro Gly Val Glu Cys Tyr Cys Gln His 
                 85                  90                  95
Asp Ser Gly Ala Ala Val Ile Gln Leu Gln Phe Leu Ile Asn Glu Gly 
             100                105                110
Ala Leu Val Ser Ala Leu Ala Asp Asp Thr Leu His Leu Trp Asn Leu 
         115                120                125
Arg Gln Lys Arg Pro Ala Val Leu His Ser Leu Lys Phe Cys Arg Glu 
     130                135                140
Arg Val Thr Phe Cys His Leu Pro Phe Gln Ser Lys Trp Leu Tyr Val 
 145                150                155                160
Gly Thr Glu Arg Gly Asn Ile His Ile Val Asn Val Glu Ser Phe Thr 
                 165                170                175
Leu Ser Gly Tyr Val Ile Met Trp Asn Lys Ala Ile Glu Leu Ser Ser 
             180                185                190
Lys Ser His Pro Gly Pro Val Val His Ile Ser Asp Asn Pro Met Asp 
         195                200                205
Glu Gly Lys Leu Leu Ile Gly Phe Glu Ser Gly Thr Val Val Leu Trp 
     210                215                220
Asp Leu Lys Ser Lys Lys Ala Asp Tyr Arg Tyr Thr Tyr Asp Glu Ala 
 225                230                235                240
Ile His Ser Val Ala Trp His His Glu Gly Lys Gln Phe Ile Cys Ser 
                 245                250                255
His Ser Asp Gly Thr Leu Thr Ile Trp Asn Val Arg Ser Pro Thr Lys 
             260                265                270
Pro Val Gln Thr Ile Thr Pro His Gly Lys Gln Leu Lys Asp Gly Lys 
         275                280                285
Lys Pro Glu Pro Cys Lys Pro Ile Leu Lys Val Glu Phe Lys Thr Thr 
     290                295                300
Arg Ser Gly Glu Pro Phe Ile Ile Leu Ser Gly Gly Leu Ser Tyr Asp 
 305                310                315                320
Thr Val Gly Arg Arg Pro Cys Leu Thr Val Met His Gly Lys Ser Thr 
                 325                330                335
Ala Val Leu Glu Met Asp Tyr Ser Ile Val Asp Phe Leu Thr Leu Cys 
             340                345                350
Glu Thr Pro Tyr Pro Asn Asp Phe Gln Glu Pro Tyr Ala Val Val Val 
         355                360                365
Leu Leu Glu Lys Asp Leu Val Leu Ile Asp Leu Ala Gln Asn Gly Tyr 
     370                375                380
Pro Ile Phe Glu Asn Pro Tyr Pro Leu Ser Ile His Glu Ser Pro Val 
 385                390                395                400
Thr Cys Cys Glu Tyr Phe Ala Asp Cys Pro Val Asp Leu Ile Pro Ala 
                 405                410                415
Leu Tyr Ser Val Gly Ala Arg Gln Lys Arg Gln Gly Tyr Ser Lys Lys 
             420                425                430
Glu Trp Pro Ile Asn Gly Gly Asn Trp Gly Leu Gly Ala Gln Ser Tyr 
         435                440                445
Pro Glu Ile Ile Ile Thr Gly His Ala Asp Gly Ser Ile Lys Phe Trp 
     450                455                460
Asp Ala Ser Ala Ile Thr Leu Gln Val Leu Tyr Lys Leu Lys Thr Ser 
 465                470                475                480
Lys Val Phe Glu Lys Ser Arg Asn Lys Asp Asp Arg Gln Asn Thr Asp 
                 485                490                495
Ile Val Asp Glu Asp Pro Tyr Ala Ile Gln Ile Ile Ser Trp Cys Pro 
             500                505                510
Glu Ser Arg Met Leu Cys Ile Ala Gly Val Ser Ala His Val Ile Ile 
         515                520                525
Tyr Arg Phe Ser Lys Gln Glu Val Val Thr Glu Val Ile Pro Met Leu 
     530                535                540
Glu Val Arg Leu Leu Tyr Glu Ile Asn Asp Val Glu Thr Pro Glu Gly 
 545                550                555                560
Glu Gln Pro Pro Pro Leu Ser Thr Pro Val Gly Ser Ser Thr Ser Gln 
                 565                570                575
Pro Ile Pro Pro Gln Ser His Pro Ser Thr Ser Ser Ser Ser Ser Asp 
             580                585                590
Gly Leu Arg Asp Asn Val Pro Cys Leu Lys Val Lys Asn Ser Pro Leu 
         595                600                605
Lys Gln Ser Pro Gly Tyr Gln Thr Glu Leu Val Ile Gln Leu Val Trp 
     610                615                620
Val Gly Gly Glu Pro Pro Gln Gln Ile Thr Ser Leu Ala Leu Asn Ser 
 625                630                635                640
Ser Tyr Gly Leu Val Val Phe Gly Asn Ser Asn Gly Ile Ala Met Val 
                 645                650                655
Asp Tyr Leu Gln Lys Ala Val Leu Leu Asn Leu Ser Thr Ile Glu Leu 
             660                665                670
Tyr Gly Ser Asn Asp Pro Tyr Arg Arg Glu Pro Arg Ser Pro Arg Lys 
         675                680                685
Ser Arg Gln Pro Ser Gly Ala Gly Leu Cys Asp Ile Thr Glu Gly Thr 
     690                695                700
Val Val Pro Glu Asp Arg Cys Lys Ser Pro Thr Ser Ala Lys Met Ser 
 705                710                715                720
Arg Lys Leu Ser Leu Pro Thr Asp Leu Lys Pro Asp Leu Asp Val Lys 
                 725                730                735
Asp Asn Ser Phe Ser Arg Ser Arg Ser Ser Ser Val Thr Ser Ile Asp 
             740                745                750
Lys Glu Ser Arg Glu Ala Ile Ser Ala Leu His Phe Cys Glu Thr Phe 
         755                760                765
Thr Arg Lys Ala Asp Ser Ser Pro Ser Pro Cys Leu Trp Val Gly Thr 
     770                775                780
Thr Val Gly Thr Ala Phe Val Ile Thr Leu Asn Leu Pro Leu Gly Pro 
 785                790                795                800
Glu Gln Arg Leu Leu Gln Pro Val Ile Val Ser Pro Ser Gly Thr Ile 
                 805                810                815
Leu Arg Leu Lys Gly Ala Ile Leu Arg Met Ala Phe Leu Asp Ala Ala 
             820                825                830
Gly Cys Leu Met Pro Pro Ala Tyr Glu Pro Trp Thr Glu His Asn Val 
         835                840                845
Pro Glu Glu Lys Asp Glu Lys Glu Lys Leu Lys Lys Arg Arg Pro Val 
     850                855                860
Ser Val Ser Pro Ser Ser Ser Gln Glu Ile Ser Glu Asn Gln Tyr Ala 
 865                870                875                880
Val Ile Cys Ser Glu Lys Gln Ala Lys Val Ile Ser Leu Pro Thr Gln 
                 885                890                895
Asn Cys Ala Tyr Lys Gln Asn Ile Thr Glu Thr Ser Phe Val Leu Arg 
             900                905                910
Gly Asp Ile Val Ala Leu Ser Asn Ser Val Cys Leu Ala Cys Phe Cys 
         915                920                925
Ala Asn Gly His Ile Met Thr Phe Ser Leu Pro Ser Leu Arg Pro Leu 
     930                935                940
Leu Asp Val Tyr Tyr Leu Pro Leu Thr Asn Met Arg Ile Ala Arg Thr 
 945                950                955                960
Phe Cys Phe Ala Asn Ser Gly Gln Ala Leu Tyr Leu Val Ser Pro Thr 
                 965                970                975
Glu Ile Gln Arg Leu Thr Tyr Ser Gln Glu Thr Cys Glu Asn Leu Gln 
             980                985                990
Glu Met Leu Gly Glu Leu Phe Thr Pro Val Glu Thr Pro Glu Ala Pro 
         995                1000                1005
Asn Arg Gly Phe Phe Lys Gly Leu Phe Gly Gly Gly Ala Gln Ser Leu 
     1010                1015                1020
Asp Arg Glu Glu Leu Phe Gly Glu Ser Ser Ser Gly Lys Ala Ser Arg 
 1025                1030                1035                1040
Ser Leu Ala Gln His Ile Pro Gly Pro Gly Gly Ile Glu Gly Val Lys 
                 1045                1050                1055
Gly Ala Ala Ser Gly Val Val Gly Glu Leu Ala Arg Ala Arg Leu Ala 
             1060                1065                1070
Leu Asp Glu Arg Gly Gln Lys Leu Ser Asp Leu Glu Glu Arg Thr Ala 
         1075                1080                1085
Ala Met Met Ser Ser Ala Asp Ser Phe Ser Lys His Ala His Glu Met 
     1090                1095                1100
Met Leu Lys Tyr Lys Asp Lys Lys Trp Tyr Gln Phe 
 1105                1110                1115



<210> 9126
<211> 1186
<212> PRT
<213> Homo sapiens
<308> XP_045911
<400> 9126

Met Lys Lys Phe Asn Phe Arg Lys Val Leu Asp Gly Leu Thr Ala Ser 
  1               5                  10                  15
Ser Pro Gly Ser Gly Ser Ser Ser Gly Ser Asn Ser Gly Gly Gly Ala 
             20                  25                  30
Gly Ser Gly Ser Val His Pro Ala Gly Thr Ala Gly Val Leu Arg Glu 
         35                  40                  45
Glu Ile Gln Glu Thr Leu Thr Ser Glu Tyr Phe Gln Ile Cys Lys Thr 
     50                  55                  60
Val Arg His Gly Phe Pro His Gln Pro Thr Ala Leu Ala Phe Asp Pro 
 65                  70                  75                  80
Val Gln Lys Ile Leu Ala Ile Gly Thr Arg Thr Gly Ala Ile Arg Ile 
                 85                  90                  95
Leu Gly Arg Pro Gly Val Asp Cys Tyr Cys Gln His Glu Ser Gly Ala 
             100                105                110
Ala Val Leu Gln Leu Gln Phe Leu Ile Asn Glu Gly Ala Leu Val Ser 
         115                120                125
Ala Ser Ser Asp Asp Thr Leu His Leu Trp Asn Leu Arg Gln Lys Arg 
     130                135                140
Pro Ala Ile Leu His Ser Leu Lys Phe Asn Arg Glu Arg Ile Thr Tyr 
 145                150                155                160
Cys His Leu Pro Phe Gln Ser Lys Trp Leu Tyr Val Gly Thr Glu Arg 
                 165                170                175
Gly Asn Thr His Ile Val Asn Ile Glu Ser Phe Ile Leu Ser Gly Tyr 
             180                185                190
Val Ile Met Trp Asn Lys Ala Ile Glu Leu Ser Thr Lys Thr His Pro 
         195                200                205
Gly Pro Val Val His Leu Ser Asp Ser Pro Arg Asp Glu Gly Lys Leu 
     210                215                220
Leu Ile Gly Tyr Glu Asn Gly Thr Val Val Phe Trp Asp Leu Lys Ser 
 225                230                235                240
Lys Arg Ala Glu Leu Arg Val Tyr Tyr Asp Glu Ala Ile His Ser Ile 
                 245                250                255
Asp Trp His His Glu Gly Lys Gln Phe Met Cys Ser His Ser Asp Gly 
             260                265                270
Ser Leu Thr Leu Trp Asn Leu Lys Ser Pro Ser Arg Pro Phe Gln Thr 
         275                280                285
Thr Ile Pro His Gly Lys Ser Gln Arg Glu Gly Arg Lys Ser Glu Ser 
     290                295                300
Cys Lys Pro Ile Leu Lys Val Glu Tyr Lys Thr Cys Lys Asn Ser Glu 
 305                310                315                320
Pro Phe Ile Ile Phe Ser Gly Gly Leu Ser Tyr Asp Lys Ala Cys Arg 
                 325                330                335
Arg Pro Ser Leu Thr Ile Met His Gly Lys Ala Ile Thr Val Leu Glu 
             340                345                350
Met Asp His Pro Ile Val Glu Phe Leu Thr Leu Cys Glu Thr Pro Tyr 
         355                360                365
Pro Asn Glu Phe Gln Glu Pro Tyr Ala Val Val Val Leu Leu Glu Lys 
     370                375                380
Asp Leu Ile Val Val Asp Leu Thr Gln Ser Asn Phe Pro Ile Phe Glu 
 385                390                395                400
Asn Pro Tyr Pro Met Asp Ile His Glu Ser Pro Val Thr Cys Thr Ala 
                 405                410                415
Tyr Phe Ala Asp Cys Pro Pro Asp Leu Ile Leu Val Leu Tyr Ser Ile 
             420                425                430
Gly Val Lys His Lys Lys Gln Gly Tyr Ser Asn Lys Glu Trp Pro Ile 
         435                440                445
Ser Gly Gly Ala Trp Asn Leu Gly Ala Gln Thr Tyr Pro Glu Ile Ile 
     450                455                460
Ile Thr Gly His Ala Asp Gly Ser Ile Lys Phe Trp Asp Ala Ser Ala 
 465                470                475                480
Ile Thr Leu Gln Met Leu Tyr Lys Leu Lys Thr Ser Lys Val Phe Glu 
                 485                490                495
Lys Gln Lys Val Gly Glu Gly Lys Gln Thr Cys Glu Ile Val Glu Glu 
             500                505                510
Asp Pro Phe Ala Ile Gln Met Ile Tyr Trp Cys Pro Glu Ser Arg Ile 
         515                520                525
Phe Cys Val Ser Gly Val Ser Ala Tyr Val Ile Ile Tyr Lys Phe Ser 
     530                535                540
Arg His Glu Ile Thr Thr Glu Ile Val Ser Leu Glu Val Arg Leu Gln 
 545                550                555                560
Tyr Asp Val Glu Asp Ile Ile Thr Pro Glu Pro Glu Thr Ser Pro Pro 
                 565                570                575
Phe Pro Asp Leu Ser Ala Gln Leu Pro Ser Ser Arg Ser Leu Ser Gly 
             580                585                590
Ser Thr Asn Thr Val Ala Ser Glu Gly Val Thr Lys Asp Ser Ile Pro 
         595                600                605
Cys Leu Asn Val Lys Thr Arg Pro Val Arg Met Pro Pro Gly Tyr Gln 
     610                615                620
Ala Glu Leu Val Ile Gln Leu Val Trp Val Asp Gly Glu Pro Pro Gln 
 625                630                635                640
Gln Ile Thr Ser Leu Ala Val Ser Ser Ala Tyr Gly Ile Val Ala Phe 
                 645                650                655
Gly Asn Cys Asn Gly Leu Ala Val Val Asp Phe Ile Gln Lys Thr Val 
             660                665                670
Leu Leu Ser Met Gly Thr Ile Asp Leu Tyr Arg Ser Ser Asp Leu Tyr 
         675                680                685
Gln Arg Gln Pro Arg Ser Pro Arg Lys Asn Lys Gln Phe Ile Ala Asp 
     690                695                700
Asn Phe Cys Met Arg Gly Leu Ser Asn Phe Tyr Pro Asp Leu Thr Lys 
 705                710                715                720
Arg Ile Arg Thr Ser Tyr Gln Ser Leu Thr Glu Leu Asn Asp Ser Pro 
                 725                730                735
Val Pro Leu Glu Leu Glu Arg Cys Lys Ser Pro Thr Ser Asp His Val 
             740                745                750
Asn Gly His Cys Thr Ser Pro Thr Ser Gln Ser Cys Ser Ser Gly Lys 
         755                760                765
Arg Leu Ser Ser Ala Asp Val Ser Lys Val Asn Arg Trp Gly Pro Gly 
     770                775                780
Arg Pro Pro Phe Arg Lys Ala Gln Ser Ala Ala Cys Met Glu Ile Ser 
 785                790                795                800
Leu Pro Val Thr Thr Glu Glu Asn Arg Glu Asn Ser Tyr Asn Arg Ser 
                 805                810                815
Arg Ser Ser Ser Ile Ser Ser Ile Asp Lys Asp Ser Lys Glu Ala Ile 
             820                825                830
Thr Ala Leu Tyr Phe Met Asp Ser Phe Ala Arg Lys Asn Asp Ser Thr 
         835                840                845
Ile Ser Pro Cys Leu Phe Val Gly Thr Ser Leu Gly Met Val Leu Ile 
     850                855                860
Ile Ser Leu Asn Leu Pro Leu Ala Asp Glu Gln Arg Phe Thr Glu Pro 
 865                870                875                880
Val Met Val Leu Pro Ser Gly Thr Phe Leu Ser Leu Lys Gly Ala Val 
                 885                890                895
Leu Thr Phe Ser Cys Met Asp Arg Met Gly Gly Leu Met Gln Pro Pro 
             900                905                910
Tyr Glu Val Trp Arg Asp Pro Asn Asn Ile Asp Glu Asn Glu Lys Ser 
         915                920                925
Trp Arg Arg Lys Val Val Met Asn Ser Ser Ser Ala Ser Gln Glu Ile 
     930                935                940
Gly Asp His Gln Tyr Thr Ile Ile Cys Ser Glu Lys Gln Ala Lys Val 
 945                950                955                960
Phe Ser Leu Pro Ser Gln Thr Cys Leu Tyr Val His Asn Ile Thr Glu 
                 965                970                975
Thr Ser Phe Ile Leu Gln Ala Asn Val Val Val Met Cys Ser Ser Ala 
             980                985                990
Cys Leu Ala Cys Phe Cys Ala Asn Gly His Ile Met Ile Met Ser Leu 
         995                1000                1005
Pro Ser Leu Arg Pro Met Leu Asp Val Asn Tyr Leu Pro Leu Thr Asp 
     1010                1015                1020
Met Arg Ile Ala Arg Thr Phe Cys Phe Thr Asn Glu Gly Gln Ala Leu 
 1025                1030                1035                1040
Tyr Leu Val Ser Pro Thr Glu Ile Gln Arg Leu Thr Tyr Ser Gln Glu 
                 1045                1050                1055
Met Cys Asp Asn Leu Gln Asp Met Leu Gly Asp Leu Phe Thr Pro Ile 
             1060                1065                1070
Glu Thr Pro Glu Ala Gln Asn Arg Gly Phe Leu Lys Gly Leu Phe Gly 
         1075                1080                1085
Gly Ser Gly Gln Thr Phe Asp Arg Glu Glu Leu Phe Gly Glu Ala Ser 
     1090                1095                1100
Ala Gly Lys Ala Ser Arg Ser Leu Ala Gln His Ile Pro Gly Pro Gly 
 1105                1110                1115                1120
Ser Ile Glu Gly Met Lys Gly Ala Ala Gly Gly Val Met Gly Glu Leu 
                 1125                1130                1135
Thr Arg Ala Arg Ile Ala Leu Asp Glu Arg Gly Gln Arg Leu Gly Glu 
             1140                1145                1150
Leu Glu Glu Lys Thr Ala Gly Met Met Thr Ser Ala Glu Ala Phe Ser 
         1155                1160                1165
Lys His Ala His Glu Leu Met Leu Lys Tyr Lys Asp Lys Lys Trp Tyr 
     1170                1175                1180
Gln Phe 
 1185



<210> 9127
<211> 2854
<212> DNA
<213> Rattus norvegicus
<308> U92279
<400> 9127

tcatctcct  gtgtgcacttctg  gtgctgaca  atccttgga  ccttcagac  gagccagac  ccaggctcc  60
cgctgggca  aaggaggct  ctgctagac  cttcctgtg  cagagaaaa  aggtagtga  120
ctggtgttt  aggatgtaa  ggcccggag  agcagagcg  gctctctcc  ctgcttgcc  180
gccaccctg  gagtgctgg  cggtgtttc  acaatcctt  tggtgggtg  ccccccgtg  240
aggggacct  tgagcaacg  aggcatgcc  gggaagccc  agcacttgg  tgtccccaa  300
gggcgcatg  tcctggctg  ctctgatgg  gaactgacc  gcacatcag  ttcccaggc  360
cagggtgag  gcagaggca  ctccctcag  atccacagc  tccccagtg  ccccagcag  420
cccttctcc  ctgatgagc  gcctgtggc  agctgggcc  agtcctttg  gcggctgct  480
caagaccca  ggggtctgg  ttacttcac  gagttcctg  agaaggaat  cagcgccga  540
aatgtaact  tctggcaag  ctgcgagcg  ttccaacag  tcccagcca  cgacaccaa  600
cagctagct  aggaggccc  caacatcta  catgagttc  tgtccagcc  ggcactgag  660
ccagtgaac  tcgaccgac  ggcctggct  agtgaggag  tgctggccc  gcccaggcc  720
gatatgttc  gagcacagc  gcttcagat  ttcaatttg  tgaagttcg  cagctacgc  780
cgcttcgtc  aatccccgc  gtaccaaga  tgcctgctg  ccgaggccg  gggacgccc  840
ctgcgggaa  ctggatcct  acacctcgg  agcccggac  ctgcgagga  gaagccaaa  900
ctgaagcct  gaaagtcac  gccgctcgg  gtggaagag  tggggcagc  gccgcttgc  960
gagggccgc  ctctccgca  gtcctttcg  agagagatg  cgggtggag  tgtgaattc  1020
gccctgcga  gagagtctc  gggatccct  aattcttcc  cgagtctgg  cctgggctt  1080
cttgccttt  tgagcagca  atccgagag  caccgaaag  gccttggaa  tggagaggg  1140
gagagcgaa  gccggcccg  gaagtactg  tgcgtgtat  tacctgatg  cacggcctc  1200
ttggccctg  ctcgacctg  cctcaccat  cgtgacatg  tggcaggca  ctgtgagaa  1260
agaggcctc  ctctacctg  cattaaggt  tacctggtg  gcaaagaac  gaaggccct  1320
gtcctggat  aggactgca  cgtgctggc  gaccaggaa  tgcgactgg  aaacaggat  1380
accttccag  tggagttgg  cggcctgga  cgtgtggta  ggatctctg  taagcccac  1440
aagcgtctg  aggaggcgc  gcagcctat  ttggccaag  acggcctga  cctggatca  1500
gtggtccta  acaggccag  agagaagca  ctagtggat  tggagaatc  agtgagctc  1560
gtggcttca  agacactgg  tttggacac  cttccagat  caaagacaa  ggaagccag  1620
agcatacct  cctgccgca  ccagggatg  ctccctaga  cccagacca  ggacagtca  1680
cttcctcca  tgtcctcca  tttgtcggt  gaagatgcc  gtggttcta  tgggaaacg  1740
cagacctgc  acattgaag  cctagtgga  ctgctgaat  gtgtgcaga  cagcggggc  1800
catgaccag  ggggacttc  tcgcaaaga  gacctggtc  ttccagaat  tctgcagct  1860
ccttcccaa  gaccaggtt  tcaggaggc  ccaccatag  ctgaatcaa  tattcagcc  1920
agggagggc  cttcagact  caccatcca  tcggtcctc  gacacctgt  taacaatcc  1980
ggctgtctg  atggtgcct  ggcaaacca  gcatgccac  ggtctgtgc  gcatgccct  2040
tctgtacca  gagtgtctt  ggtcccttt  tgctgtggg  aggcccaca  aaagggcca  2100
gaaggggtg  ctacttgtt  tctcatagg  ttacctacc  attcctcac  gtaggccat  2160
aaggggagg  gggccttgt  ccttggcat  agcatactg  acatgaaga  gtgactttg  2220
cagtgtcag  ctccttgac  tgttctagg  tttagcagg  ggcaggaag  aggggctgg  2280
ccctcctta  agagttggt  taagaaaga  ctgggtgta  tactgggca  cccctccct  2340
catccacag  ttttgctgt  catatggat  ttatggttg  cttggggca  ctgggtttg  2400
cctggatgt  tgatactgt  ataataata  ttattatta  tcagccacg  ggtgtcttt  2460
ttttgtctt  ttttttcgg  gctgggaac  gaacccagg  ccttgcgct  gttaggcaa  2520
cgctctacc  ctgagctaa  tccccaacc  catgaggtg  ctttcttgt  tgccactct  2580
ccctgtgta  tctcactac  ccactgcct  tgtgccagg  caggaagtt  tggggaacc  2640
tagtgtata  ctcctcact  cttgttttc  gaatctctc  ccccaaggc  taggatata  2700
aaggcaggg  ggggggagc  gaatggaga  ggagagagc  ccacccccc  ccccctact  2760
ttcttggcc  tcacccagc  gctccacaa  gtccatggg  gatgaatgt  tcctttttg  2820
ttctgttct  tttctgttg  tgatacaat  tatc  2854



<210> 9128
<211> 544
<212> PRT
<213> Rattus norvegicus
<308> O08773
<400> 9128

Met Pro Gly Lys Pro Lys His Leu Gly Val Pro Asn Gly Arg Met Val 
  1               5                  10                  15
Leu Ala Val Ser Asp Gly Glu Leu Thr Ser Thr Ser Gly Ser Gln Ala 
             20                  25                  30
Gln Gly Glu Gly Arg Gly Ser Ser Leu Ser Ile His Ser Leu Pro Ser 
         35                  40                  45
Gly Pro Ser Ser Pro Phe Ser Thr Asp Glu Gln Pro Val Ala Ser Trp 
     50                  55                  60
Ala Gln Ser Phe Glu Arg Leu Leu Gln Asp Pro Arg Gly Leu Ala Tyr 
 65                  70                  75                  80
Phe Thr Glu Phe Leu Lys Lys Glu Phe Ser Ala Glu Asn Val Thr Phe 
                 85                  90                  95
Trp Gln Ala Cys Glu Arg Phe Gln Gln Ile Pro Ala Ser Asp Thr Lys 
             100                105                110
Gln Leu Ala Gln Glu Ala His Asn Ile Tyr His Glu Phe Leu Ser Ser 
         115                120                125
Gln Ala Leu Ser Pro Val Asn Ile Asp Arg Gln Ala Trp Leu Ser Glu 
     130                135                140
Glu Val Leu Ala Gln Pro Arg Pro Asp Met Phe Arg Ala Gln Gln Leu 
 145                150                155                160
Gln Ile Phe Asn Leu Met Lys Phe Asp Ser Tyr Ala Arg Phe Val Lys 
                 165                170                175
Ser Pro Leu Tyr Gln Glu Cys Leu Leu Ala Glu Ala Glu Gly Arg Pro 
             180                185                190
Leu Arg Glu Pro Gly Ser Ser His Leu Gly Ser Pro Asp Thr Ala Arg 
         195                200                205
Lys Lys Pro Lys Leu Lys Pro Gly Lys Ser Leu Pro Leu Gly Val Glu 
     210                215                220
Glu Leu Gly Gln Leu Pro Leu Ala Glu Gly Arg Pro Leu Arg Lys Ser 
 225                230                235                240
Phe Arg Arg Glu Met Pro Gly Gly Ala Val Asn Ser Ala Leu Arg Arg 
                 245                250                255
Glu Ser Gln Gly Ser Leu Asn Ser Ser Ala Ser Leu Asp Leu Gly Phe 
             260                265                270
Leu Ala Phe Val Ser Ser Lys Ser Glu Ser His Arg Lys Ser Leu Gly 
         275                280                285
Ser Gly Glu Gly Glu Ser Glu Ser Arg Pro Gly Lys Tyr Cys Cys Val 
     290                295                300
Tyr Leu Pro Asp Gly Thr Ala Ser Leu Ala Leu Ala Arg Pro Gly Leu 
 305                310                315                320
Thr Ile Arg Asp Met Leu Ala Gly Ile Cys Glu Lys Arg Gly Leu Ser 
                 325                330                335
Leu Pro Asp Ile Lys Val Tyr Leu Val Gly Lys Glu Gln Lys Ala Leu 
             340                345                350
Val Leu Asp Gln Asp Cys Thr Val Leu Ala Asp Gln Glu Val Arg Leu 
         355                360                365
Glu Asn Arg Ile Thr Phe Gln Leu Glu Leu Val Gly Leu Glu Arg Val 
     370                375                380
Val Arg Ile Ser Ala Lys Pro Thr Lys Arg Leu Gln Glu Ala Leu Gln 
 385                390                395                400
Pro Ile Leu Ala Lys His Gly Leu Ser Leu Asp Gln Val Val Leu His 
                 405                410                415
Arg Pro Gly Glu Lys Gln Leu Val Asp Leu Glu Asn Leu Val Ser Ser 
             420                425                430
Val Ala Ser Gln Thr Leu Val Leu Asp Thr Leu Pro Asp Ala Lys Thr 
         435                440                445
Arg Glu Ala Ser Ser Ile Pro Pro Cys Arg Ser Gln Gly Cys Leu Pro 
     450                455                460
Arg Thr Gln Thr Lys Asp Ser His Leu Pro Pro Leu Ser Ser Ser Leu 
 465                470                475                480
Ser Val Glu Asp Ala Ser Gly Ser Thr Gly Lys Arg Gln Thr Cys Asp 
                 485                490                495
Ile Glu Gly Leu Val Glu Leu Leu Asn Arg Val Gln Ser Ser Gly Ala 
             500                505                510
His Asp Gln Arg Gly Leu Leu Arg Lys Glu Asp Leu Val Leu Pro Glu 
         515                520                525
Phe Leu Gln Leu Pro Ser Gln Arg Pro Gly Ser Gln Glu Ala Pro Pro 
     530                535                540



<210> 9129
<211> 822
<212> DNA
<213> Homo sapiens
<308> AF037194
<400> 9129

tcgtgtgag  ccagtgaac  tcgaccgtc  ggcctggct  ggcgaggag  tgctggccg  60
gccccggcc  gacatgttt  gggcacagc  gcttcagat  ttcaacttg  tgaagttcg  120
cagctatgc  cgcttcgtc  agtccccgc  gtaccgcga  tgcctgcta  ccgaagccg  180
gggacgccc  ctgcgggaa  ctggctcct  gcgcctcgg  agccctgac  ccacgagga  240
gaagccgaa  ctgaagccc  ggaagtcgc  gccgctggg  gtggaggag  tggggcagc  300
gccacccgt  gagggtcct  ggggccgcc  tctccgcaa  tccttccgc  gggagctgg  360
cgggactgc  aacgccgcc  tgcgccgag  gtctcaggg  tccctcaac  cctccgcca  420
cctggacct  ggcttccta  ccttcgtca  cagcaaatc  gagagccac  ggaagagcc  480
tgggagcac  gagggtgaa  gtgaaagcc  gccagggaa  tactgctgt  tgtacctgc  540
cgatggcac  gcctccttg  ccctggcca  acctggcct  accatccga  acatgctgg  600
agggatctg  gagaaacga  gcctctctc  acctgacat  aaggtctac  tggtgggca  660
tgaacaggt  ggaacgtga  ctggctcca  ctctaacct  cttcctgat  ctgacccca  720
ctccatttc  gtctctgct  agtcatggc  ccaacccca  ttcaagttc  aaacccaac  780
ccaaagcac  ctcagcacc  actttcact  actcagaca  cc  822



<210> 9130
<211> 594
<212> PRT
<213> Homo sapiens
<308> O43566
<400> 9130

Met Pro Gly Lys Pro Lys His Leu Gly Val Pro Asn Gly Arg Met Val 
  1               5                  10                  15
Leu Ala Val Ser Asp Gly Glu Leu Ser Ser Thr Thr Gly Pro Gln Gly 
             20                  25                  30
Gln Gly Glu Gly Arg Gly Ser Ser Leu Ser Ile His Ser Leu Pro Ser 
         35                  40                  45
Gly Pro Ser Ser Pro Phe Pro Thr Glu Glu Gln Pro Val Ala Ser Trp 
     50                  55                  60
Ala Leu Ser Phe Glu Arg Leu Leu Gln Asp Pro Leu Gly Leu Ala Tyr 
 65                  70                  75                  80
Phe Thr Glu Phe Leu Lys Lys Glu Phe Ser Ala Glu Asn Val Thr Phe 
                 85                  90                  95
Trp Lys Ala Cys Glu Arg Phe Gln Gln Ile Pro Ala Ser Asp Thr Gln 
             100                105                110
Gln Leu Ala Gln Glu Ala Arg Asn Ile Tyr Gln Glu Phe Leu Ser Ser 
         115                120                125
Gln Ala Leu Ser Pro Val Asn Ile Asp Arg Gln Ala Trp Leu Gly Glu 
     130                135                140
Glu Val Leu Ala Glu Pro Arg Pro Asp Met Phe Arg Ala Gln Gln Leu 
 145                150                155                160
Gln Ile Phe Asn Leu Met Lys Phe Asp Ser Tyr Ala Arg Phe Val Lys 
                 165                170                175
Ser Pro Leu Tyr Arg Glu Cys Leu Leu Ala Glu Ala Glu Gly Arg Pro 
             180                185                190
Leu Arg Glu Pro Gly Ser Ser Arg Leu Gly Ser Pro Asp Ala Thr Arg 
         195                200                205
Lys Lys Pro Lys Leu Lys Pro Gly Lys Ser Leu Pro Leu Gly Val Glu 
     210                215                220
Glu Leu Gly Gln Leu Pro Pro Val Glu Gly Pro Gly Gly Arg Pro Leu 
 225                230                235                240
Arg Lys Ser Phe Arg Arg Glu Leu Gly Gly Thr Ala Asn Ala Ala Leu 
                 245                250                255
Arg Arg Glu Ser Gln Gly Ser Leu Asn Ser Ser Ala Ser Leu Asp Leu 
             260                265                270
Gly Phe Leu Ala Phe Val Ser Ser Lys Ser Glu Ser His Arg Lys Ser 
         275                280                285
Leu Gly Ser Thr Glu Gly Glu Ser Glu Ser Arg Pro Gly Lys Tyr Cys 
     290                295                300
Cys Val Tyr Leu Pro Asp Gly Thr Ala Ser Leu Ala Leu Ala Arg Pro 
 305                310                315                320
Gly Leu Thr Ile Arg Asp Met Leu Ala Gly Ile Cys Glu Lys Arg Gly 
                 325                330                335
Ser Leu Tyr Leu Thr Ser Ser Leu Pro Gly Gly Asn Glu Gln Lys Ala 
             340                345                350
Leu Val Leu Asp Gln Asp Cys Thr Val Leu Ala Asp Gln Glu Val Arg 
         355                360                365
Leu Glu Asn Arg Ile Thr Phe Glu Leu Glu Leu Thr Ala Leu Glu Arg 
     370                375                380
Val Val Arg Ile Ser Ala Lys Pro Thr Lys Arg Leu Gln Glu Ala Leu 
 385                390                395                400
Gln Pro Ile Leu Glu Lys His Gly Leu Ser Pro Leu Glu Val Val Leu 
                 405                410                415
His Arg Pro Gly Glu Lys Gln Pro Leu Asp Leu Gly Lys Leu Val Ser 
             420                425                430
Ser Val Ala Ala Gln Arg Leu Val Leu Asp Thr Leu Pro Gly Val Lys 
         435                440                445
Ile Ser Lys Ala Arg Asp Lys Ser Pro Cys Arg Ser Gln Gly Cys Pro 
     450                455                460
Pro Arg Thr Gln Asp Lys Ala Thr His Pro Pro Pro Ala Ser Pro Ser 
 465                470                475                480
Ser Leu Val Lys Val Pro Ser Ser Ala Thr Gly Lys Arg Gln Thr Cys 
                 485                490                495
Asp Ile Glu Gly Leu Glu Leu Leu Asn Arg Val Gln Ser Ser Gly Ala 
             500                505                510
His Asp Gln Arg Gly Leu Leu Arg Lys Glu Asp Leu Val Leu Pro Glu 
         515                520                525
Phe Leu Gln Leu Pro Ala Gln Gly Pro Ala Pro Arg Arg Pro Thr Thr 
     530                535                540
Asp Gln Ile Ser Ser Pro Ala His Arg Gly Ile Leu Glu Leu His His 
 545                550                555                560
Arg Leu Ser Pro Leu Thr Ala Thr Gln Gln Ser Arg Thr Ala Ala Trp 
                 565                570                575
His Pro Ala Gly Arg Ala Cys His Gly Ser Ala Leu His Ala Leu Ser 
             580                585                590
Val Pro 
         595



<210> 9131
<211> 4665
<212> DNA
<213> Rattus norvegicus
<308> U92564
<400> 9131

attgcttgc  tcctagggg  cagggctgt  ctgagcacg  cacaccaat  caagcttca  60
aaacaccta  gggcagttg  agaggggga  gcctcggac  tctcgctgg  ctgggattc  120
tctgtggca  cagcgggag  cctagaagg  gagtcagag  gtgatcgga  atccagccg  180
gcgctggaa  acaggaaca  cgtgacaag  caagaggag  gaaacgagg  cgatgaaga  240
gtggaagat  agtcaattt  cacctgcga  cactgtcag  aggacttcg  gtctctggc  300
gacctgacg  accaccggg  ccaccgctg  cctggagat  gtgatgacg  cccacagct  360
tcctgggtg  cttcatctc  ctccagcaa  gatgttgcg  cacccacgc  gatgatcgg  420
gatggttgt  accttggcc  cggcgagga  gaaggcggc  ccggcctgc  gtacccttg  480
cagttctgc  acaagtcct  catccgcct  agctacttg  agaggcatg  acagatcca  540
agcgacaag  tgccgttca  gtgcacctt  tgcagccgc  tcttcaaac  caagaggag  600
cgggaccgg  acatcaagc  gcacacagg  gacaagaag  accactgcc  cgagtgcga  660
gcggctttc  cccgcaggg  ccacctcaa  atccacctg  agacccaca  ctccagcaa  720
ccgttcaag  gcagcgtgt  caaacgcgg  ttctcctcc  ccagctccc  gcagagcca  780
atgcaggcc  acaagaaga  taaggaaca  ctggctaag  cagagaagg  agccaagaa  840
gacgacttc  tgtgtgact  ctgcgagga  acctttagc  agacagaag  gctggagaa  900
catgtgctt  ccctccacc  gcagctctc  gagaaggcg  acctccagt  tatccactg  960
cccgaggtc  ttgtcgacg  gagcacgct  ctggcccac  tccaccaag  tcacgccaa  1020
cagaaacac  agtgcccca  gtgccctga  cagttctcc  ccgtggagg  tgtgtactg  1080
cacctggac  gccaccggc  gcctgattc  agcaatcac  gtgtcagcc  cgaccccgt  1140
ctgggcagt  tggcttcca  gagcagtgc  acacctgac  cgacgcccg  ccccgtgct  1200
ggcagtgtg  cttccatga  cagtgctac  cctgactcg  gcgcctctg  ggagcgcgg  1260
tccacgcca  actccacct  gaagccgct  agggggcag  agaagatgc  ggatgacgg  1320
cagagctgg  ccaaggttg  ctacagctg  ccctactgt  ctaagcggg  ctttaccag  1380
ctggctgtg  tagagattc  tctgaagac  attcacgcg  acaaacctc  gcagagtca  1440
acgtgtcag  tttgcctgg  ctccatgcc  acgctctac  acctcaacg  gcatgtgcg  1500
aagctgcac  agagccacg  ttaccccgt  atgcaattc  gcaacatct  cgccttcca  1560
tgcaactac  gccccgaga  gttcgcgga  atcaacagc  tgcaggagc  catccgagt  1620
tcgcactgt  gccccaatg  caacccccc  gacgggaac  atgctttct  ctgtaacca  1680
tgttctatg  gctttctca  tgaatcctc  ctcacagag  acatccaac  ggcacactg  1740
agtgtgggg  gcaccaagc  ggagtctcc  gttatccag  ccacacagt  cttcatgga  1800
gtctactcc  gcccttact  taccaactc  cctatcttt  gctccatcc  gaagctcac  1860
aagcacatc  aagagaacc  caagaacat  ccgttggca  acagcaaga  gtccaaggc  1920
gagcagagt  cggtctcct  tgacgtcga  gtgtcttcc  cgaaacgac  gcgcctctc  1980
gggagtgcc  actccatct  taacggcga  tacccctgc  atcagtgcg  cctcaagtt  2040
tccaacttc  agagcttcc  gacccactt  aagctgcac  tggagctgc  gctccggaa  2100
caggcctgc  cccagtgca  agaggactt  gactctcag  agtccctcc  gcagcatct  2160
accgtgcac  acatgacca  gtccaccca  tacgtctgc  agagctgtg  caagcagtt  2220
tcctcagtg  acgacctgc  gaagcacct  ctggacatg  acacctttg  gctatacca  2280
tgcaccctg  gtcaggagg  cttcgactc  aaggtgtcc  tccaggtgc  cctggccgt  2340
aagcacagc  acgagaaga  gatgtaccg  tgcaccgcc  gcaactggg  cttccgcaa  2400
gaggctgac  tgcaggtgc  cgtcaagca  agtcacctc  gcaacccgg  caaggccca  2460
aagtgcatc  tctgtggtg  gaccttcag  accgaggtg  agctccagt  ccacatcac  2520
acgcacagc  agaagtaca  ttgcaggtt  tgcagcaaa  ccttccacg  cgtcctcct  2580
ctggagaag  accttcggg  gaagcattg  gtgtttgac  cagctgcag  gaatggcac  2640
gccaacggg  tgcccccca  ctccaccaa  aaggcagag  ccgccgacc  gcagggcat  2700
ctgctcaag  accctgagg  accgaacag  cacgaggcc  gtgaggacg  tgtggatgc  2760
tcagagccc  tgtacggct  tgacatctg  ggtgcagcc  acaccatgg  ggtgctgct  2820
cagaaccac  gactccggg  tcataacat  cggcccgga  aggacgatg  ctcacgcaa  2880
aaggcagag  tcataaagg  cagccacaa  tgtaacgtg  gctctcgga  tttcttctc  2940
gagaacggg  tccgggaac  cctgcagac  caccggggc  ctgccaagc  ctacatgtg  3000
cccatctgt  gcgagcgct  cccctcgct  ctgacgctc  ctgagcaca  ggtgaccca  3060
agcaagagt  tggacacag  cacctgtcg  atctgcaaa  tgcccctgc  gagtgagga  3120
gagtttatc  agcactgcc  gatgcaccc  gacttgcgg  actccctca  tggtttccg  3180
tgtgtggtc  gtatgcaga  tgtcacctc  accctggag  tcaagatcc  tggcacctt  3240
cacatgcag  agctggctg  cagctcagc  gcttcctcc  ccaatggcc  ggggctgca  3300
aagctctac  agtgcgccc  gtgcctcaa  gagttccgt  gcaagcagg  cctggtcag  3360
cttgacgtc  atgggctgc  ctatggcct  tgtgccggc  gcatggccc  tagtgccaa  3420
ggacaggtg  gtggcctgg  cccacccga  cctgccgac  ggccctgcg  tggcctccg  3480
tgccctgaa  gtaacgtga  gtttgagag  gctgaggac  tggagagcc  catgcaggt  3540
gaccaccgt  atcttaccc  agagaccag  gggccccgg  aaggtgccc  gacgtcacc  3600
gtgccccgg  agaagacgt  ccagtgcat  aagtgccag  tgaccttcg  gaacgagag  3660
gagatccag  tccacgtcg  caaccacat  atcgaggaa  gcatcaacc  tgagtgtaa  3720
ctgtgcaac  agatgttcg  ctccccagc  aagctcctt  gtcacctca  cgaacacag  3780
ttcgagggc  tgggtggta  tttcaagtg  cccgtgtgc  tcacagtct  cgtccaggc  3840
aacaagctg  aacagcaca  cttcgccgt  cacgggcag  aggacaaaa  ctacgactg  3900
tcgcagtgc  cacagaagt  tttcttcca  acagagttg  agaaccaca  gatgagcca  3960
cacgcacag  gagggacct  gcgacagga  acctctccg  agaaggctt  ccggagacg  4020
cgtggggag  gccatttga  cattacatc  aatcaaagt  tcatttgca  cccagatgt  4080
aaactctaa  gatttggcc  tgaggcgct  ctattataa  cagctggaa  tgaatatta  4140
tggcagaga  taaaagtat  ccatgctca  tgtttttta  tgtcctgct  cagctagtg  4200
gcttttaga  ttttcgccg  agactacat  tctagtgtt  gagaaacct  cttttttga  4260
gctattgtc  tttgttcct  catgtatta  attgatagt  ttttttaaa  gattagtgt  4320
atttttttt  cttcttttc  atttctttc  ttcttgttt  tctttctcc  ccttcagtt  4380
actactttt  aattgaaat  ctaggtaat  gtgcatcgt  atgtgattg  ttggctatt  4440
tctgaatat  tccttttaa  tttttaatt  aagactaat  ctttgattg  atttgccag  4500
tcaccggac  gtgattaaa  ctctgtaat  aaaataatc  gtttccgtg  aactggatg  4560
tctgctttt  aatgtgact  gatctgact  cagtaacta  ttcagctca  taaagggaa  4620
ccatgcgtt  acccccaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  4665



<210> 9132
<211> 1186
<212> PRT
<213> Rattus norvegicus
<308> AAB58646
<400> 9132

Met Ile Gly Asp Gly Cys Asp Leu Gly Leu Gly Glu Glu Glu Gly Gly 
  1               5                  10                  15
Thr Gly Leu Pro Tyr Pro Cys Gln Phe Cys Asp Lys Ser Phe Ile Arg 
             20                  25                  30
Leu Ser Tyr Leu Lys Arg His Glu Gln Ile His Ser Asp Lys Leu Pro 
         35                  40                  45
Phe Lys Cys Thr Phe Cys Ser Arg Leu Phe Lys His Lys Arg Ser Arg 
     50                  55                  60
Asp Arg His Ile Lys Leu His Thr Gly Asp Lys Lys Tyr His Cys His 
 65                  70                  75                  80
Glu Cys Glu Ala Ala Phe Ser Arg Arg Asp His Leu Lys Ile His Leu 
                 85                  90                  95
Lys Thr His Ser Ser Ser Lys Pro Phe Lys Cys Ser Val Cys Lys Arg 
             100                105                110
Gly Phe Ser Ser Thr Ser Ser Leu Gln Ser His Met Gln Ala His Lys 
         115                120                125
Lys Asn Lys Glu His Leu Ala Lys Ser Glu Lys Glu Ala Lys Lys Asp 
     130                135                140
Asp Phe Met Cys Asp Tyr Cys Glu Asp Thr Phe Ser Gln Thr Glu Glu 
 145                150                155                160
Leu Glu Lys His Val Leu Thr Leu His Pro Gln Leu Ser Glu Lys Ala 
                 165                170                175
Asp Leu Gln Cys Ile His Cys Pro Glu Val Phe Val Asp Glu Ser Thr 
             180                185                190
Leu Leu Ala His Ile His Gln Ala His Ala Asn Gln Lys His Lys Cys 
         195                200                205
Pro Met Cys Pro Glu Gln Phe Ser Ser Val Glu Gly Val Tyr Cys His 
     210                215                220
Leu Asp Ser His Arg Gln Pro Asp Ser Ser Asn His Ser Val Ser Pro 
 225                230                235                240
Asp Pro Val Leu Gly Ser Val Ala Ser Met Ser Ser Ala Thr Pro Asp 
                 245                250                255
Ser Thr Pro Asp Pro Val Leu Gly Ser Val Ala Ser Met Ser Ser Ala 
             260                265                270
Thr Pro Asp Ser Ser Ala Ser Val Glu Arg Gly Ser Thr Pro Asp Ser 
         275                280                285
Thr Leu Lys Pro Leu Arg Gly Gln Lys Lys Met Arg Asp Asp Gly Gln 
     290                295                300
Ser Trp Ser Lys Val Val Tyr Ser Cys Pro Tyr Cys Ser Lys Arg Asp 
 305                310                315                320
Phe Thr Ser Leu Ala Val Leu Glu Ile His Leu Lys Thr Ile His Ala 
                 325                330                335
Asp Lys Pro Gln Gln Ser His Thr Cys Gln Ile Cys Leu Asp Ser Met 
             340                345                350
Pro Thr Leu Tyr Asn Leu Asn Glu His Val Arg Lys Leu His Lys Ser 
         355                360                365
His Ala Tyr Pro Val Met Gln Phe Gly Asn Ile Ser Ala Phe His Cys 
     370                375                380
Asn Tyr Cys Pro Glu Met Phe Ala Asp Ile Asn Ser Leu Gln Glu His 
 385                390                395                400
Ile Arg Val Ser His Cys Gly Pro Asn Ala Asn Pro Pro Asp Gly Asn 
                 405                410                415
Asn Ala Phe Phe Cys Asn Gln Cys Ser Met Gly Phe Leu Thr Glu Ser 
             420                425                430
Ser Leu Thr Glu His Ile Gln Gln Ala His Cys Ser Val Gly Ser Thr 
         435                440                445
Lys Leu Glu Ser Pro Val Ile Gln Pro Thr Gln Ser Phe Met Glu Val 
     450                455                460
Tyr Ser Cys Pro Tyr Cys Thr Asn Ser Pro Ile Phe Gly Ser Ile Leu 
 465                470                475                480
Lys Leu Thr Lys His Ile Lys Glu Asn His Lys Asn Ile Pro Leu Ala 
                 485                490                495
His Ser Lys Lys Ser Lys Ala Glu Gln Ser Pro Val Ser Ser Asp Val 
             500                505                510
Glu Val Ser Ser Pro Lys Arg Gln Arg Leu Ser Gly Ser Ala Asn Ser 
         515                520                525
Ile Ser Asn Gly Glu Tyr Pro Cys Asn Gln Cys Asp Leu Lys Phe Ser 
     530                535                540
Asn Phe Glu Ser Phe Gln Thr His Leu Lys Leu His Leu Glu Leu Leu 
 545                550                555                560
Leu Arg Lys Gln Ala Cys Pro Gln Cys Lys Glu Asp Phe Asp Ser Gln 
                 565                570                575
Glu Ser Leu Leu Gln His Leu Thr Val His Tyr Met Thr Thr Ser Thr 
             580                585                590
His Tyr Val Cys Glu Ser Cys Asp Lys Gln Phe Ser Ser Val Asp Asp 
         595                600                605
Leu Gln Lys His Leu Leu Asp Met His Thr Phe Val Leu Tyr His Cys 
     610                615                620
Thr Leu Cys Gln Glu Val Phe Asp Ser Lys Val Ser Ile Gln Val His 
 625                630                635                640
Leu Ala Val Lys His Ser Asn Glu Lys Lys Met Tyr Arg Cys Thr Ala 
                 645                650                655
Cys Asn Trp Asp Phe Arg Lys Glu Ala Asp Leu Gln Val His Val Lys 
             660                665                670
His Ser His Leu Gly Asn Pro Ala Lys Ala His Lys Cys Ile Phe Cys 
         675                680                685
Gly Glu Thr Phe Ser Thr Glu Val Glu Leu Gln Cys His Ile Thr Thr 
     690                695                700
His Ser Lys Lys Tyr Asn Cys Arg Phe Cys Ser Lys Ala Phe His Ala 
 705                710                715                720
Val Leu Leu Leu Glu Lys His Leu Arg Glu Lys His Cys Val Phe Asp 
                 725                730                735
Pro Ala Ala Glu Asn Gly Thr Ala Asn Gly Val Pro Pro Thr Ser Thr 
             740                745                750
Lys Lys Ala Glu Pro Ala Asp Leu Gln Gly Met Leu Leu Lys Asn Pro 
         755                760                765
Glu Ala Pro Asn Ser His Glu Ala Ser Glu Asp Asp Val Asp Ala Ser 
     770                775                780
Glu Pro Met Tyr Gly Cys Asp Ile Cys Gly Ala Ala Tyr Thr Met Glu 
 785                790                795                800
Val Leu Leu Gln Asn His Arg Leu Arg Asp His Asn Ile Arg Pro Gly 
                 805                810                815
Glu Asp Asp Gly Ser Arg Lys Lys Ala Glu Phe Ile Lys Gly Ser His 
             820                825                830
Lys Cys Asn Val Cys Ser Arg Thr Phe Phe Ser Glu Asn Gly Leu Arg 
         835                840                845
Glu His Leu Gln Thr His Arg Gly Pro Ala Lys His Tyr Met Cys Pro 
     850                855                860
Ile Cys Gly Glu Arg Phe Pro Ser Leu Leu Thr Leu Thr Glu His Lys 
 865                870                875                880
Val Thr His Ser Lys Ser Leu Asp Thr Gly Thr Cys Arg Ile Cys Lys 
                 885                890                895
Met Pro Leu Gln Ser Glu Glu Glu Phe Ile Glu His Cys Gln Met His 
             900                905                910
Pro Asp Leu Arg Asn Ser Leu Thr Gly Phe Arg Cys Val Val Cys Met 
         915                920                925
Gln Thr Val Thr Ser Thr Leu Glu Leu Lys Ile His Gly Thr Phe His 
     930                935                940
Met Gln Lys Leu Ala Gly Ser Ser Ala Ala Ser Ser Pro Asn Gly Gln 
 945                950                955                960
Gly Leu Gln Lys Leu Tyr Lys Cys Ala Leu Cys Leu Lys Glu Phe Arg 
                 965                970                975
Ser Lys Gln Asp Leu Val Arg Leu Asp Val Asn Gly Leu Pro Tyr Gly 
             980                985                990
Leu Cys Ala Gly Cys Met Ala Arg Ser Ala Asn Gly Gln Val Gly Gly 
         995                1000                1005
Leu Ala Pro Pro Glu Pro Ala Asp Arg Pro Cys Ala Gly Leu Arg Cys 
     1010                1015                1020
Pro Glu Cys Asn Val Lys Phe Glu Ser Ala Glu Asp Leu Glu Ser His 
 1025                1030                1035                1040
Met Gln Val Asp His Arg Asp Leu Thr Pro Glu Thr Ser Gly Pro Arg 
                 1045                1050                1055
Lys Gly Ala Gln Thr Ser Pro Val Pro Arg Lys Lys Thr Tyr Gln Cys 
             1060                1065                1070
Ile Lys Cys Gln Met Thr Phe Glu Asn Glu Arg Glu Ile Gln Ile His 
         1075                1080                1085
Val Ala Asn His Met Ile Glu Glu Gly Ile Asn His Glu Cys Lys Leu 
     1090                1095                1100
Cys Asn Gln Met Phe Asp Ser Pro Ala Lys Leu Leu Cys His Leu Ile 
 1105                1110                1115                1120
Glu His Ser Phe Glu Gly Met Gly Gly Thr Phe Lys Cys Pro Val Cys 
                 1125                1130                1135
Phe Thr Val Phe Val Gln Ala Asn Lys Leu Gln Gln His Ile Phe Ala 
             1140                1145                1150
Val His Gly Gln Glu Asp Lys Ile Tyr Asp Cys Ser Gln Cys Pro Gln 
         1155                1160                1165
Lys Phe Phe Phe Gln Thr Glu Leu Gln Asn His Thr Met Ser Gln His 
     1170                1175                1180
Ala Gln 
 1185



<210> 9133
<211> 4248
<212> DNA
<213> Homo sapiens
<308> AB018303
<400> 9133

atggaggat  aatcaattt  cacctgcga  cactgtcag  aggacttcg  gtctctggc  60
gacctgacg  accaccggg  ccaccgctg  cctggagat  gtgatgacg  cccacaact  120
tcctgggtg  cctcgtctc  ctccagcaa  gatgttgcg  cacccacgc  gatgatcgg  180
gatggttgt  acctcggcc  cggcgagga  gaagggggc  cgggcctgc  atacccttg  240
cagttctgc  acaagtcct  catccgctt  agctacttg  agaggcacg  gcagatcca  300
agcgacaag  tgccgttca  gtgcaccta  tgcagccgc  tcttcaagc  caagaggag  360
cgcgaccgg  acatcaagc  gcatacggg  gacaagaag  atcactgcc  cgagtgcga  420
gcagccttc  cccgcagcg  ccacctcaa  atccacctg  agacccaca  ctccagcaa  480
cccttcaag  gcactgtgt  caagcgcgg  ttctcctcc  ccagctcgc  gcagagcca  540
atgcaggcc  acaaaaaga  caaggagca  ctggccaag  cggagaagg  agccaagaa  600
gacgacttc  tgtgcgact  ctgcgagga  accttcagc  agacggagg  gctggagaa  660
cacgtgctc  cccgccacc  gcagctgtc  gagaaggcg  acctgcagt  cattcactg  720
cctgaggtc  tcgtcgacg  gaacacact  ctcgcccat  tccaccaag  ccacgccaa  780
cagaaacac  agtgcccca  gtgccctga  cagttctcc  cagtggaag  tgtctactg  840
cacctggac  gccaccggc  gcccgactc  agcaaccac  gtgtcagtc  cgaccctgt  900
ctgggcagc  tggcctcca  gagcagcgc  acacccgac  ccagcgcct  tgtggagcg  960
ggctccacc  cggactcca  cttgaagcc  ctgcggggg  agaagaaga  gcgggatga  1020
gggcagggc  ggaccaagg  ggtctatag  tgcccctat  gttccaagc  ggactttaa  1080
agcctggcc  tgctggaga  ccacctgaa  accatccac  cggacaagc  ccagcagag  1140
cacacatgt  agatctgcc  ggactccat  cccaccctc  acaacctca  cgagcacgt  1200
cgcaagctg  acaagaacc  tgcctaccc  gtgatgcag  ttggcaaca  ctctgcctt  1260
cactgcaac  actgccccg  gatgttcgc  gacatcaat  gcctgcagg  gcacatccg  1320
gtctcccac  gcggcccca  cgccaaccc  tctgacggt  ataatgctt  cttctgcaa  1380
cagtgctcc  tgggtttcc  tactgagtc  tccctcacc  agcacatcc  gcaggccca  1440
tgcagtgtg  gcagtgcca  actagagtc  ccggtggtg  agcccacgc  gtccttcat  1500
gaggtctat  cctgcccct  ctgcaccaa  tcccccatc  ttggctcca  cctgaaact  1560
accaagcac  tcaaggaga  ccacaagaa  attccactg  cccacagca  gaagtccaa  1620
gccgagcag  gcccagtct  gtccgatgt  gaggtgtct  ccccgaagc  gcagcggct  1680
tcagcaagc  ccaactcca  ctccaatgg  gagtatcct  gcaatcaat  cgacctcaa  1740
ttctccaac  ttgagagct  ccagaccca  ctgaagctg  acctggagc  gctgctgcg  1800
aagcaagcg  gcccccagt  caaagagga  tttgactcc  aggagtccc  cctgcagca  1860
ctgacagtg  attacatga  cacgtcgac  cactatgtg  gcgagagct  cgacaagca  1920
ttttcctcg  tggatgacc  gcagaagca  ctgctggac  tgcacacct  tgtgttgta  1980
cactgcacc  tgtgtcagg  ggtcttcga  tccaaggtg  ccatccagg  gcacctggc  2040
gtgaagcac  gcaatgaga  gaagatgta  cgctgcacg  cctgcaact  ggacttccg  2100
aaggaggct  acctgcagg  gcacgtcaa  cacagccac  tgggcaacc  ggccaaggc  2160
cacaagtgc  tcttctgtg  ggagacctt  agcaccgag  tggagctgc  gtgccacat  2220
accacacac  gcaagaagt  taactgtaa  ttctgcagc  aggccttcc  cgccatcat  2280
ctgctggag  agcacctgc  ggagaagca  tgtgtgttt  atgctgcga  cgagaacgg  2340
acggccaat  gggtacccc  aatggccac  aagaaagct  agcctgctg  cctgcaggg  2400
atgctgctt  agaaccctg  ggcacctaa  agccatgag  ccagcgagg  tgacgtgga  2460
gcgtcggag  ccatgtacg  ctgtgacat  tgcggggcg  cctacacca  ggaggtgct  2520
ctgcagaat  accggctgc  ggaccacaa  atccggccg  gcgaggatg  tggctcacg  2580
aagaaggct  agtttatca  gggcagtca  aagtgcaac  tttgttcac  gactttctt  2640
tcggagaac  ggctacggg  gcacctgca  acgcaccgg  gccctgcca  gcactacat  2700
tgtcccatc  gtggtgagc  cttcccttc  ctgctgacg  tcaccgaac  caaggtgac  2760
cacagcaag  gcctggaca  gggcacctg  cgcatctgc  agatgcccc  gcagagcga  2820
gaggagttt  ttgagcact  ccagatgca  cctgacctg  gcaactcac  cacgggctt  2880
cgctgtgtg  tctgcatgc  gacagtcac  tccacgctt  agctcaaga  ccatggcac  2940
ttccacatg  agaagctgg  gggcagctc  gcggcgtcc  cccccaatg  ccaggggct  3000
cagaagctc  acaagtgcg  cctgtgcct  aaggagttc  gcagcaagc  ggacctggt  3060
aagcttgac  tcaatgggc  gccctacgg  ctctgcgcc  gctgcatgg  ccgcagcgc  3120
aacggacag  tgggtggcc  ggccccgcc  gagcccgcc  accggccct  tgccggcct  3180
cgttgcccc  agtgcagtg  caagtttga  agtgccgaa  acctggaga  ccacatgca  3240
gtggaccac  gtgacctca  gccggagac  agtgggccc  ggaaaggca  ccagacatc  3300
ccagtgccc  ggaaaaaga  ataccagtg  atcaagtgc  agatgacct  cgagaacga  3360
agagagatc  aaatccacg  tgccaacca  atgattgag  aaggcatca  ccacgagtg  3420
aagctgtgc  accagatgt  cgactcccc  gccaagctc  tctgtcacc  cattgagca  3480
agcttcgag  gcatgggcg  caccttcaa  tgccccgtg  gtttcacag  cttcgtcca  3540
gccaacaag  tgcagcagc  catctttgc  gtgcacggg  aggaggaca  gatctacga  3600
tgctcacag  gccctcaga  gttcttctt  cagaccgag  tgcagaacc  cacgatgag  3660
cagcacgca  agtgaggga  cgctcaaca  gacacctct  cgcagaagg  ttgccggag  3720
cgccgtggg  agggccatt  gaacattac  tccaatcaa  gtgtcattt  caacccaga  3780
gtaaaactc  aatgatttg  ccatgaggc  ctgctatta  aagcagctg  aaatgaata  3840
taatggcag  gattaaaag  attccatgc  cagtatttt  tattgtcct  ctacagcta  3900
tgtgctttt  gactttccg  cgcagacta  atttctaga  ttagagaaa  ctgcttttt  3960
aggctattg  cctttgttc  ttcatgtat  atattgata  tttttaaaa  agaattagt  4020
tgatttttt  tctttgctt  ttttttttc  ttcttgttt  tcttccccc  caccccccc  4080
cccccttcg  ttaactact  tttaattgc  attctaggt  attgtgcat  gtgatgtga  4140
tgcttggct  ttgtctgaa  atttccttt  aatttttta  ttaaagact  atgctttga  4200
tggatttgc  agttcaccg  acagtgatt  aaactatgt  atgaatat  4248



<210> 9134
<211> 1224
<212> PRT
<213> Homo sapiens
<308> BAA34480
<400> 9134

Met Glu Asp Glu Ser Ile Tyr Thr Cys Asp His Cys Gln Gln Asp Phe 
  1               5                  10                  15
Glu Ser Leu Ala Asp Leu Thr Asp His Arg Ala His Arg Cys Pro Gly 
             20                  25                  30
Asp Gly Asp Asp Asp Pro Gln Leu Ser Trp Val Ala Ser Ser Pro Ser 
         35                  40                  45
Ser Lys Asp Val Ala Ser Pro Thr Gln Met Ile Gly Asp Gly Cys Asp 
     50                  55                  60
Leu Gly Leu Gly Glu Glu Glu Gly Gly Thr Gly Leu Pro Tyr Pro Cys 
 65                  70                  75                  80
Gln Phe Cys Asp Lys Ser Phe Ile Arg Leu Ser Tyr Leu Lys Arg His 
                 85                  90                  95
Glu Gln Ile His Ser Asp Lys Leu Pro Phe Lys Cys Thr Tyr Cys Ser 
             100                105                110
Arg Leu Phe Lys His Lys Arg Ser Arg Asp Arg His Ile Lys Leu His 
         115                120                125
Thr Gly Asp Lys Lys Tyr His Cys His Glu Cys Glu Ala Ala Phe Ser 
     130                135                140
Arg Ser Asp His Leu Lys Ile His Leu Lys Thr His Ser Ser Ser Lys 
 145                150                155                160
Pro Phe Lys Cys Thr Val Cys Lys Arg Gly Phe Ser Ser Thr Ser Ser 
                 165                170                175
Leu Gln Ser His Met Gln Ala His Lys Lys Asn Lys Glu His Leu Ala 
             180                185                190
Lys Ser Glu Lys Glu Ala Lys Lys Asp Asp Phe Met Cys Asp Tyr Cys 
         195                200                205
Glu Asp Thr Phe Ser Gln Thr Glu Glu Leu Glu Lys His Val Leu Thr 
     210                215                220
Arg His Pro Gln Leu Ser Glu Lys Ala Asp Leu Gln Cys Ile His Cys 
 225                230                235                240
Pro Glu Val Phe Val Asp Glu Asn Thr Leu Leu Ala His Ile His Gln 
                 245                250                255
Ala His Ala Asn Gln Lys His Lys Cys Pro Met Cys Pro Glu Gln Phe 
             260                265                270
Ser Ser Val Glu Gly Val Tyr Cys His Leu Asp Ser His Arg Gln Pro 
         275                280                285
Asp Ser Ser Asn His Ser Val Ser Pro Asp Pro Val Leu Gly Ser Val 
     290                295                300
Ala Ser Met Ser Ser Ala Thr Pro Asp Ser Ser Ala Ser Val Glu Arg 
 305                310                315                320
Gly Ser Thr Pro Asp Ser Thr Leu Lys Pro Leu Arg Gly Gln Lys Lys 
                 325                330                335
Met Arg Asp Asp Gly Gln Gly Trp Thr Lys Val Val Tyr Ser Cys Pro 
             340                345                350
Tyr Cys Ser Lys Arg Asp Phe Asn Ser Leu Ala Val Leu Glu Ile His 
         355                360                365
Leu Lys Thr Ile His Ala Asp Lys Pro Gln Gln Ser His Thr Cys Gln 
     370                375                380
Ile Cys Leu Asp Ser Met Pro Thr Leu Tyr Asn Leu Asn Glu His Val 
 385                390                395                400
Arg Lys Leu His Lys Asn His Ala Tyr Pro Val Met Gln Phe Gly Asn 
                 405                410                415
Ile Ser Ala Phe His Cys Asn Tyr Cys Pro Glu Met Phe Ala Asp Ile 
             420                425                430
Asn Ser Leu Gln Glu His Ile Arg Val Ser His Cys Gly Pro Asn Ala 
         435                440                445
Asn Pro Ser Asp Gly Asn Asn Ala Phe Phe Cys Asn Gln Cys Ser Met 
     450                455                460
Gly Phe Leu Thr Glu Ser Ser Leu Thr Glu His Ile Gln Gln Ala His 
 465                470                475                480
Cys Ser Val Gly Ser Ala Lys Leu Glu Ser Pro Val Val Gln Pro Thr 
                 485                490                495
Gln Ser Phe Met Glu Val Tyr Ser Cys Pro Tyr Cys Thr Asn Ser Pro 
             500                505                510
Ile Phe Gly Ser Ile Leu Lys Leu Thr Lys His Ile Lys Glu Asn His 
         515                520                525
Lys Asn Ile Pro Leu Ala His Ser Lys Lys Ser Lys Ala Glu Gln Ser 
     530                535                540
Pro Val Ser Ser Asp Val Glu Val Ser Ser Pro Lys Arg Gln Arg Leu 
 545                550                555                560
Ser Ala Ser Ala Asn Ser Ile Ser Asn Gly Glu Tyr Pro Cys Asn Gln 
                 565                570                575
Cys Asp Leu Lys Phe Ser Asn Phe Glu Ser Phe Gln Thr His Leu Lys 
             580                585                590
Leu His Leu Glu Leu Leu Leu Arg Lys Gln Ala Cys Pro Gln Cys Lys 
         595                600                605
Glu Asp Phe Asp Ser Gln Glu Ser Leu Leu Gln His Leu Thr Val His 
     610                615                620
Tyr Met Thr Thr Ser Thr His Tyr Val Cys Glu Ser Cys Asp Lys Gln 
 625                630                635                640
Phe Ser Ser Val Asp Asp Leu Gln Lys His Leu Leu Asp Met His Thr 
                 645                650                655
Phe Val Leu Tyr His Cys Thr Leu Cys Gln Glu Val Phe Asp Ser Lys 
             660                665                670
Val Ser Ile Gln Val His Leu Ala Val Lys His Ser Asn Glu Lys Lys 
         675                680                685
Met Tyr Arg Cys Thr Ala Cys Asn Trp Asp Phe Arg Lys Glu Ala Asp 
     690                695                700
Leu Gln Val His Val Lys His Ser His Leu Gly Asn Pro Ala Lys Ala 
 705                710                715                720
His Lys Cys Ile Phe Cys Gly Glu Thr Phe Ser Thr Glu Val Glu Leu 
                 725                730                735
Gln Cys His Ile Thr Thr His Ser Lys Lys Tyr Asn Cys Lys Phe Cys 
             740                745                750
Ser Lys Ala Phe His Ala Ile Ile Leu Leu Glu Lys His Leu Arg Glu 
         755                760                765
Lys His Cys Val Phe Asp Ala Ala Thr Glu Asn Gly Thr Ala Asn Gly 
     770                775                780
Val Pro Pro Met Ala Thr Lys Lys Ala Glu Pro Ala Asp Leu Gln Gly 
 785                790                795                800
Met Leu Leu Lys Asn Pro Glu Ala Pro Asn Ser His Glu Ala Ser Glu 
                 805                810                815
Asp Asp Val Asp Ala Ser Glu Pro Met Tyr Gly Cys Asp Ile Cys Gly 
             820                825                830
Ala Ala Tyr Thr Met Glu Val Leu Leu Gln Asn His Arg Leu Arg Asp 
         835                840                845
His Asn Ile Arg Pro Gly Glu Asp Asp Gly Ser Arg Lys Lys Ala Glu 
     850                855                860
Phe Ile Lys Gly Ser His Lys Cys Asn Val Cys Ser Arg Thr Phe Phe 
 865                870                875                880
Ser Glu Asn Gly Leu Arg Glu His Leu Gln Thr His Arg Gly Pro Ala 
                 885                890                895
Lys His Tyr Met Cys Pro Ile Cys Gly Glu Arg Phe Pro Ser Leu Leu 
             900                905                910
Thr Leu Thr Glu His Lys Val Thr His Ser Lys Ser Leu Asp Thr Gly 
         915                920                925
Thr Cys Arg Ile Cys Lys Met Pro Leu Gln Ser Glu Glu Glu Phe Ile 
     930                935                940
Glu His Cys Gln Met His Pro Asp Leu Arg Asn Ser Leu Thr Gly Phe 
 945                950                955                960
Arg Cys Val Val Cys Met Gln Thr Val Thr Ser Thr Leu Glu Leu Lys 
                 965                970                975
Ile His Gly Thr Phe His Met Gln Lys Leu Ala Gly Ser Ser Ala Ala 
             980                985                990
Ser Ser Pro Asn Gly Gln Gly Leu Gln Lys Leu Tyr Lys Cys Ala Leu 
         995                1000                1005
Cys Leu Lys Glu Phe Arg Ser Lys Gln Asp Leu Val Lys Leu Asp Val 
     1010                1015                1020
Asn Gly Leu Pro Tyr Gly Leu Cys Ala Gly Cys Met Ala Arg Ser Ala 
 1025                1030                1035                1040
Asn Gly Gln Val Gly Gly Leu Ala Pro Pro Glu Pro Ala Asp Arg Pro 
                 1045                1050                1055
Cys Ala Gly Leu Arg Cys Pro Glu Cys Ser Val Lys Phe Glu Ser Ala 
             1060                1065                1070
Glu Asp Leu Glu Ser His Met Gln Val Asp His Arg Asp Leu Thr Pro 
         1075                1080                1085
Glu Thr Ser Gly Pro Arg Lys Gly Thr Gln Thr Ser Pro Val Pro Arg 
     1090                1095                1100
Lys Lys Thr Tyr Gln Cys Ile Lys Cys Gln Met Thr Phe Glu Asn Glu 
 1105                1110                1115                1120
Arg Glu Ile Gln Ile His Val Ala Asn His Met Ile Glu Glu Gly Ile 
                 1125                1130                1135
Asn His Glu Cys Lys Leu Cys Asn Gln Met Phe Asp Ser Pro Ala Lys 
             1140                1145                1150
Leu Leu Cys His Leu Ile Glu His Ser Phe Glu Gly Met Gly Gly Thr 
         1155                1160                1165
Phe Lys Cys Pro Val Cys Phe Thr Val Phe Val Gln Ala Asn Lys Leu 
     1170                1175                1180
Gln Gln His Ile Phe Ala Val His Gly Gln Glu Asp Lys Ile Tyr Asp 
 1185                1190                1195                1200
Cys Ser Gln Cys Pro Gln Lys Phe Phe Phe Gln Thr Glu Leu Gln Asn 
                 1205                1210                1215
His Thr Met Ser Gln His Ala Gln 
             1220



<210> 9135
<211> 4665
<212> DNA
<213> Rattus norvegicus
<308> U92564
<400> 9135

attgcttgc  tcctagggg  cagggctgt  ctgagcacg  cacaccaat  caagcttca  60
aaacaccta  gggcagttg  agaggggga  gcctcggac  tctcgctgg  ctgggattc  120
tctgtggca  cagcgggag  cctagaagg  gagtcagag  gtgatcgga  atccagccg  180
gcgctggaa  acaggaaca  cgtgacaag  caagaggag  gaaacgagg  cgatgaaga  240
gtggaagat  agtcaattt  cacctgcga  cactgtcag  aggacttcg  gtctctggc  300
gacctgacg  accaccggg  ccaccgctg  cctggagat  gtgatgacg  cccacagct  360
tcctgggtg  cttcatctc  ctccagcaa  gatgttgcg  cacccacgc  gatgatcgg  420
gatggttgt  accttggcc  cggcgagga  gaaggcggc  ccggcctgc  gtacccttg  480
cagttctgc  acaagtcct  catccgcct  agctacttg  agaggcatg  acagatcca  540
agcgacaag  tgccgttca  gtgcacctt  tgcagccgc  tcttcaaac  caagaggag  600
cgggaccgg  acatcaagc  gcacacagg  gacaagaag  accactgcc  cgagtgcga  660
gcggctttc  cccgcaggg  ccacctcaa  atccacctg  agacccaca  ctccagcaa  720
ccgttcaag  gcagcgtgt  caaacgcgg  ttctcctcc  ccagctccc  gcagagcca  780
atgcaggcc  acaagaaga  taaggaaca  ctggctaag  cagagaagg  agccaagaa  840
gacgacttc  tgtgtgact  ctgcgagga  acctttagc  agacagaag  gctggagaa  900
catgtgctt  ccctccacc  gcagctctc  gagaaggcg  acctccagt  tatccactg  960
cccgaggtc  ttgtcgacg  gagcacgct  ctggcccac  tccaccaag  tcacgccaa  1020
cagaaacac  agtgcccca  gtgccctga  cagttctcc  ccgtggagg  tgtgtactg  1080
cacctggac  gccaccggc  gcctgattc  agcaatcac  gtgtcagcc  cgaccccgt  1140
ctgggcagt  tggcttcca  gagcagtgc  acacctgac  cgacgcccg  ccccgtgct  1200
ggcagtgtg  cttccatga  cagtgctac  cctgactcg  gcgcctctg  ggagcgcgg  1260
tccacgcca  actccacct  gaagccgct  agggggcag  agaagatgc  ggatgacgg  1320
cagagctgg  ccaaggttg  ctacagctg  ccctactgt  ctaagcggg  ctttaccag  1380
ctggctgtg  tagagattc  tctgaagac  attcacgcg  acaaacctc  gcagagtca  1440
acgtgtcag  tttgcctgg  ctccatgcc  acgctctac  acctcaacg  gcatgtgcg  1500
aagctgcac  agagccacg  ttaccccgt  atgcaattc  gcaacatct  cgccttcca  1560
tgcaactac  gccccgaga  gttcgcgga  atcaacagc  tgcaggagc  catccgagt  1620
tcgcactgt  gccccaatg  caacccccc  gacgggaac  atgctttct  ctgtaacca  1680
tgttctatg  gctttctca  tgaatcctc  ctcacagag  acatccaac  ggcacactg  1740
agtgtgggg  gcaccaagc  ggagtctcc  gttatccag  ccacacagt  cttcatgga  1800
gtctactcc  gcccttact  taccaactc  cctatcttt  gctccatcc  gaagctcac  1860
aagcacatc  aagagaacc  caagaacat  ccgttggca  acagcaaga  gtccaaggc  1920
gagcagagt  cggtctcct  tgacgtcga  gtgtcttcc  cgaaacgac  gcgcctctc  1980
gggagtgcc  actccatct  taacggcga  tacccctgc  atcagtgcg  cctcaagtt  2040
tccaacttc  agagcttcc  gacccactt  aagctgcac  tggagctgc  gctccggaa  2100
caggcctgc  cccagtgca  agaggactt  gactctcag  agtccctcc  gcagcatct  2160
accgtgcac  acatgacca  gtccaccca  tacgtctgc  agagctgtg  caagcagtt  2220
tcctcagtg  acgacctgc  gaagcacct  ctggacatg  acacctttg  gctatacca  2280
tgcaccctg  gtcaggagg  cttcgactc  aaggtgtcc  tccaggtgc  cctggccgt  2340
aagcacagc  acgagaaga  gatgtaccg  tgcaccgcc  gcaactggg  cttccgcaa  2400
gaggctgac  tgcaggtgc  cgtcaagca  agtcacctc  gcaacccgg  caaggccca  2460
aagtgcatc  tctgtggtg  gaccttcag  accgaggtg  agctccagt  ccacatcac  2520
acgcacagc  agaagtaca  ttgcaggtt  tgcagcaaa  ccttccacg  cgtcctcct  2580
ctggagaag  accttcggg  gaagcattg  gtgtttgac  cagctgcag  gaatggcac  2640
gccaacggg  tgcccccca  ctccaccaa  aaggcagag  ccgccgacc  gcagggcat  2700
ctgctcaag  accctgagg  accgaacag  cacgaggcc  gtgaggacg  tgtggatgc  2760
tcagagccc  tgtacggct  tgacatctg  ggtgcagcc  acaccatgg  ggtgctgct  2820
cagaaccac  gactccggg  tcataacat  cggcccgga  aggacgatg  ctcacgcaa  2880
aaggcagag  tcataaagg  cagccacaa  tgtaacgtg  gctctcgga  tttcttctc  2940
gagaacggg  tccgggaac  cctgcagac  caccggggc  ctgccaagc  ctacatgtg  3000
cccatctgt  gcgagcgct  cccctcgct  ctgacgctc  ctgagcaca  ggtgaccca  3060
agcaagagt  tggacacag  cacctgtcg  atctgcaaa  tgcccctgc  gagtgagga  3120
gagtttatc  agcactgcc  gatgcaccc  gacttgcgg  actccctca  tggtttccg  3180
tgtgtggtc  gtatgcaga  tgtcacctc  accctggag  tcaagatcc  tggcacctt  3240
cacatgcag  agctggctg  cagctcagc  gcttcctcc  ccaatggcc  ggggctgca  3300
aagctctac  agtgcgccc  gtgcctcaa  gagttccgt  gcaagcagg  cctggtcag  3360
cttgacgtc  atgggctgc  ctatggcct  tgtgccggc  gcatggccc  tagtgccaa  3420
ggacaggtg  gtggcctgg  cccacccga  cctgccgac  ggccctgcg  tggcctccg  3480
tgccctgaa  gtaacgtga  gtttgagag  gctgaggac  tggagagcc  catgcaggt  3540
gaccaccgt  atcttaccc  agagaccag  gggccccgg  aaggtgccc  gacgtcacc  3600
gtgccccgg  agaagacgt  ccagtgcat  aagtgccag  tgaccttcg  gaacgagag  3660
gagatccag  tccacgtcg  caaccacat  atcgaggaa  gcatcaacc  tgagtgtaa  3720
ctgtgcaac  agatgttcg  ctccccagc  aagctcctt  gtcacctca  cgaacacag  3780
ttcgagggc  tgggtggta  tttcaagtg  cccgtgtgc  tcacagtct  cgtccaggc  3840
aacaagctg  aacagcaca  cttcgccgt  cacgggcag  aggacaaaa  ctacgactg  3900
tcgcagtgc  cacagaagt  tttcttcca  acagagttg  agaaccaca  gatgagcca  3960
cacgcacag  gagggacct  gcgacagga  acctctccg  agaaggctt  ccggagacg  4020
cgtggggag  gccatttga  cattacatc  aatcaaagt  tcatttgca  cccagatgt  4080
aaactctaa  gatttggcc  tgaggcgct  ctattataa  cagctggaa  tgaatatta  4140
tggcagaga  taaaagtat  ccatgctca  tgtttttta  tgtcctgct  cagctagtg  4200
gcttttaga  ttttcgccg  agactacat  tctagtgtt  gagaaacct  cttttttga  4260
gctattgtc  tttgttcct  catgtatta  attgatagt  ttttttaaa  gattagtgt  4320
atttttttt  cttcttttc  atttctttc  ttcttgttt  tctttctcc  ccttcagtt  4380
actactttt  aattgaaat  ctaggtaat  gtgcatcgt  atgtgattg  ttggctatt  4440
tctgaatat  tccttttaa  tttttaatt  aagactaat  ctttgattg  atttgccag  4500
tcaccggac  gtgattaaa  ctctgtaat  aaaataatc  gtttccgtg  aactggatg  4560
tctgctttt  aatgtgact  gatctgact  cagtaacta  ttcagctca  taaagggaa  4620
ccatgcgtt  acccccaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  4665



<210> 9136
<211> 1186
<212> PRT
<213> Rattus norvegicus
<308> AAB58646
<400> 9136

Met Ile Gly Asp Gly Cys Asp Leu Gly Leu Gly Glu Glu Glu Gly Gly 
  1               5                  10                  15
Thr Gly Leu Pro Tyr Pro Cys Gln Phe Cys Asp Lys Ser Phe Ile Arg 
             20                  25                  30
Leu Ser Tyr Leu Lys Arg His Glu Gln Ile His Ser Asp Lys Leu Pro 
         35                  40                  45
Phe Lys Cys Thr Phe Cys Ser Arg Leu Phe Lys His Lys Arg Ser Arg 
     50                  55                  60
Asp Arg His Ile Lys Leu His Thr Gly Asp Lys Lys Tyr His Cys His 
 65                  70                  75                  80
Glu Cys Glu Ala Ala Phe Ser Arg Arg Asp His Leu Lys Ile His Leu 
                 85                  90                  95
Lys Thr His Ser Ser Ser Lys Pro Phe Lys Cys Ser Val Cys Lys Arg 
             100                105                110
Gly Phe Ser Ser Thr Ser Ser Leu Gln Ser His Met Gln Ala His Lys 
         115                120                125
Lys Asn Lys Glu His Leu Ala Lys Ser Glu Lys Glu Ala Lys Lys Asp 
     130                135                140
Asp Phe Met Cys Asp Tyr Cys Glu Asp Thr Phe Ser Gln Thr Glu Glu 
 145                150                155                160
Leu Glu Lys His Val Leu Thr Leu His Pro Gln Leu Ser Glu Lys Ala 
                 165                170                175
Asp Leu Gln Cys Ile His Cys Pro Glu Val Phe Val Asp Glu Ser Thr 
             180                185                190
Leu Leu Ala His Ile His Gln Ala His Ala Asn Gln Lys His Lys Cys 
         195                200                205
Pro Met Cys Pro Glu Gln Phe Ser Ser Val Glu Gly Val Tyr Cys His 
     210                215                220
Leu Asp Ser His Arg Gln Pro Asp Ser Ser Asn His Ser Val Ser Pro 
 225                230                235                240
Asp Pro Val Leu Gly Ser Val Ala Ser Met Ser Ser Ala Thr Pro Asp 
                 245                250                255
Ser Thr Pro Asp Pro Val Leu Gly Ser Val Ala Ser Met Ser Ser Ala 
             260                265                270
Thr Pro Asp Ser Ser Ala Ser Val Glu Arg Gly Ser Thr Pro Asp Ser 
         275                280                285
Thr Leu Lys Pro Leu Arg Gly Gln Lys Lys Met Arg Asp Asp Gly Gln 
     290                295                300
Ser Trp Ser Lys Val Val Tyr Ser Cys Pro Tyr Cys Ser Lys Arg Asp 
 305                310                315                320
Phe Thr Ser Leu Ala Val Leu Glu Ile His Leu Lys Thr Ile His Ala 
                 325                330                335
Asp Lys Pro Gln Gln Ser His Thr Cys Gln Ile Cys Leu Asp Ser Met 
             340                345                350
Pro Thr Leu Tyr Asn Leu Asn Glu His Val Arg Lys Leu His Lys Ser 
         355                360                365
His Ala Tyr Pro Val Met Gln Phe Gly Asn Ile Ser Ala Phe His Cys 
     370                375                380
Asn Tyr Cys Pro Glu Met Phe Ala Asp Ile Asn Ser Leu Gln Glu His 
 385                390                395                400
Ile Arg Val Ser His Cys Gly Pro Asn Ala Asn Pro Pro Asp Gly Asn 
                 405                410                415
Asn Ala Phe Phe Cys Asn Gln Cys Ser Met Gly Phe Leu Thr Glu Ser 
             420                425                430
Ser Leu Thr Glu His Ile Gln Gln Ala His Cys Ser Val Gly Ser Thr 
         435                440                445
Lys Leu Glu Ser Pro Val Ile Gln Pro Thr Gln Ser Phe Met Glu Val 
     450                455                460
Tyr Ser Cys Pro Tyr Cys Thr Asn Ser Pro Ile Phe Gly Ser Ile Leu 
 465                470                475                480
Lys Leu Thr Lys His Ile Lys Glu Asn His Lys Asn Ile Pro Leu Ala 
                 485                490                495
His Ser Lys Lys Ser Lys Ala Glu Gln Ser Pro Val Ser Ser Asp Val 
             500                505                510
Glu Val Ser Ser Pro Lys Arg Gln Arg Leu Ser Gly Ser Ala Asn Ser 
         515                520                525
Ile Ser Asn Gly Glu Tyr Pro Cys Asn Gln Cys Asp Leu Lys Phe Ser 
     530                535                540
Asn Phe Glu Ser Phe Gln Thr His Leu Lys Leu His Leu Glu Leu Leu 
 545                550                555                560
Leu Arg Lys Gln Ala Cys Pro Gln Cys Lys Glu Asp Phe Asp Ser Gln 
                 565                570                575
Glu Ser Leu Leu Gln His Leu Thr Val His Tyr Met Thr Thr Ser Thr 
             580                585                590
His Tyr Val Cys Glu Ser Cys Asp Lys Gln Phe Ser Ser Val Asp Asp 
         595                600                605
Leu Gln Lys His Leu Leu Asp Met His Thr Phe Val Leu Tyr His Cys 
     610                615                620
Thr Leu Cys Gln Glu Val Phe Asp Ser Lys Val Ser Ile Gln Val His 
 625                630                635                640
Leu Ala Val Lys His Ser Asn Glu Lys Lys Met Tyr Arg Cys Thr Ala 
                 645                650                655
Cys Asn Trp Asp Phe Arg Lys Glu Ala Asp Leu Gln Val His Val Lys 
             660                665                670
His Ser His Leu Gly Asn Pro Ala Lys Ala His Lys Cys Ile Phe Cys 
         675                680                685
Gly Glu Thr Phe Ser Thr Glu Val Glu Leu Gln Cys His Ile Thr Thr 
     690                695                700
His Ser Lys Lys Tyr Asn Cys Arg Phe Cys Ser Lys Ala Phe His Ala 
 705                710                715                720
Val Leu Leu Leu Glu Lys His Leu Arg Glu Lys His Cys Val Phe Asp 
                 725                730                735
Pro Ala Ala Glu Asn Gly Thr Ala Asn Gly Val Pro Pro Thr Ser Thr 
             740                745                750
Lys Lys Ala Glu Pro Ala Asp Leu Gln Gly Met Leu Leu Lys Asn Pro 
         755                760                765
Glu Ala Pro Asn Ser His Glu Ala Ser Glu Asp Asp Val Asp Ala Ser 
     770                775                780
Glu Pro Met Tyr Gly Cys Asp Ile Cys Gly Ala Ala Tyr Thr Met Glu 
 785                790                795                800
Val Leu Leu Gln Asn His Arg Leu Arg Asp His Asn Ile Arg Pro Gly 
                 805                810                815
Glu Asp Asp Gly Ser Arg Lys Lys Ala Glu Phe Ile Lys Gly Ser His 
             820                825                830
Lys Cys Asn Val Cys Ser Arg Thr Phe Phe Ser Glu Asn Gly Leu Arg 
         835                840                845
Glu His Leu Gln Thr His Arg Gly Pro Ala Lys His Tyr Met Cys Pro 
     850                855                860
Ile Cys Gly Glu Arg Phe Pro Ser Leu Leu Thr Leu Thr Glu His Lys 
 865                870                875                880
Val Thr His Ser Lys Ser Leu Asp Thr Gly Thr Cys Arg Ile Cys Lys 
                 885                890                895
Met Pro Leu Gln Ser Glu Glu Glu Phe Ile Glu His Cys Gln Met His 
             900                905                910
Pro Asp Leu Arg Asn Ser Leu Thr Gly Phe Arg Cys Val Val Cys Met 
         915                920                925
Gln Thr Val Thr Ser Thr Leu Glu Leu Lys Ile His Gly Thr Phe His 
     930                935                940
Met Gln Lys Leu Ala Gly Ser Ser Ala Ala Ser Ser Pro Asn Gly Gln 
 945                950                955                960
Gly Leu Gln Lys Leu Tyr Lys Cys Ala Leu Cys Leu Lys Glu Phe Arg 
                 965                970                975
Ser Lys Gln Asp Leu Val Arg Leu Asp Val Asn Gly Leu Pro Tyr Gly 
             980                985                990
Leu Cys Ala Gly Cys Met Ala Arg Ser Ala Asn Gly Gln Val Gly Gly 
         995                1000                1005
Leu Ala Pro Pro Glu Pro Ala Asp Arg Pro Cys Ala Gly Leu Arg Cys 
     1010                1015                1020
Pro Glu Cys Asn Val Lys Phe Glu Ser Ala Glu Asp Leu Glu Ser His 
 1025                1030                1035                1040
Met Gln Val Asp His Arg Asp Leu Thr Pro Glu Thr Ser Gly Pro Arg 
                 1045                1050                1055
Lys Gly Ala Gln Thr Ser Pro Val Pro Arg Lys Lys Thr Tyr Gln Cys 
             1060                1065                1070
Ile Lys Cys Gln Met Thr Phe Glu Asn Glu Arg Glu Ile Gln Ile His 
         1075                1080                1085
Val Ala Asn His Met Ile Glu Glu Gly Ile Asn His Glu Cys Lys Leu 
     1090                1095                1100
Cys Asn Gln Met Phe Asp Ser Pro Ala Lys Leu Leu Cys His Leu Ile 
 1105                1110                1115                1120
Glu His Ser Phe Glu Gly Met Gly Gly Thr Phe Lys Cys Pro Val Cys 
                 1125                1130                1135
Phe Thr Val Phe Val Gln Ala Asn Lys Leu Gln Gln His Ile Phe Ala 
             1140                1145                1150
Val His Gly Gln Glu Asp Lys Ile Tyr Asp Cys Ser Gln Cys Pro Gln 
         1155                1160                1165
Lys Phe Phe Phe Gln Thr Glu Leu Gln Asn His Thr Met Ser Gln His 
     1170                1175                1180
Ala Gln 
 1185



<210> 9137
<211> 4248
<212> DNA
<213> Homo sapiens
<308> AB018303
<400> 9137

atggaggat  aatcaattt  cacctgcga  cactgtcag  aggacttcg  gtctctggc  60
gacctgacg  accaccggg  ccaccgctg  cctggagat  gtgatgacg  cccacaact  120
tcctgggtg  cctcgtctc  ctccagcaa  gatgttgcg  cacccacgc  gatgatcgg  180
gatggttgt  acctcggcc  cggcgagga  gaagggggc  cgggcctgc  atacccttg  240
cagttctgc  acaagtcct  catccgctt  agctacttg  agaggcacg  gcagatcca  300
agcgacaag  tgccgttca  gtgcaccta  tgcagccgc  tcttcaagc  caagaggag  360
cgcgaccgg  acatcaagc  gcatacggg  gacaagaag  atcactgcc  cgagtgcga  420
gcagccttc  cccgcagcg  ccacctcaa  atccacctg  agacccaca  ctccagcaa  480
cccttcaag  gcactgtgt  caagcgcgg  ttctcctcc  ccagctcgc  gcagagcca  540
atgcaggcc  acaaaaaga  caaggagca  ctggccaag  cggagaagg  agccaagaa  600
gacgacttc  tgtgcgact  ctgcgagga  accttcagc  agacggagg  gctggagaa  660
cacgtgctc  cccgccacc  gcagctgtc  gagaaggcg  acctgcagt  cattcactg  720
cctgaggtc  tcgtcgacg  gaacacact  ctcgcccat  tccaccaag  ccacgccaa  780
cagaaacac  agtgcccca  gtgccctga  cagttctcc  cagtggaag  tgtctactg  840
cacctggac  gccaccggc  gcccgactc  agcaaccac  gtgtcagtc  cgaccctgt  900
ctgggcagc  tggcctcca  gagcagcgc  acacccgac  ccagcgcct  tgtggagcg  960
ggctccacc  cggactcca  cttgaagcc  ctgcggggg  agaagaaga  gcgggatga  1020
gggcagggc  ggaccaagg  ggtctatag  tgcccctat  gttccaagc  ggactttaa  1080
agcctggcc  tgctggaga  ccacctgaa  accatccac  cggacaagc  ccagcagag  1140
cacacatgt  agatctgcc  ggactccat  cccaccctc  acaacctca  cgagcacgt  1200
cgcaagctg  acaagaacc  tgcctaccc  gtgatgcag  ttggcaaca  ctctgcctt  1260
cactgcaac  actgccccg  gatgttcgc  gacatcaat  gcctgcagg  gcacatccg  1320
gtctcccac  gcggcccca  cgccaaccc  tctgacggt  ataatgctt  cttctgcaa  1380
cagtgctcc  tgggtttcc  tactgagtc  tccctcacc  agcacatcc  gcaggccca  1440
tgcagtgtg  gcagtgcca  actagagtc  ccggtggtg  agcccacgc  gtccttcat  1500
gaggtctat  cctgcccct  ctgcaccaa  tcccccatc  ttggctcca  cctgaaact  1560
accaagcac  tcaaggaga  ccacaagaa  attccactg  cccacagca  gaagtccaa  1620
gccgagcag  gcccagtct  gtccgatgt  gaggtgtct  ccccgaagc  gcagcggct  1680
tcagcaagc  ccaactcca  ctccaatgg  gagtatcct  gcaatcaat  cgacctcaa  1740
ttctccaac  ttgagagct  ccagaccca  ctgaagctg  acctggagc  gctgctgcg  1800
aagcaagcg  gcccccagt  caaagagga  tttgactcc  aggagtccc  cctgcagca  1860
ctgacagtg  attacatga  cacgtcgac  cactatgtg  gcgagagct  cgacaagca  1920
ttttcctcg  tggatgacc  gcagaagca  ctgctggac  tgcacacct  tgtgttgta  1980
cactgcacc  tgtgtcagg  ggtcttcga  tccaaggtg  ccatccagg  gcacctggc  2040
gtgaagcac  gcaatgaga  gaagatgta  cgctgcacg  cctgcaact  ggacttccg  2100
aaggaggct  acctgcagg  gcacgtcaa  cacagccac  tgggcaacc  ggccaaggc  2160
cacaagtgc  tcttctgtg  ggagacctt  agcaccgag  tggagctgc  gtgccacat  2220
accacacac  gcaagaagt  taactgtaa  ttctgcagc  aggccttcc  cgccatcat  2280
ctgctggag  agcacctgc  ggagaagca  tgtgtgttt  atgctgcga  cgagaacgg  2340
acggccaat  gggtacccc  aatggccac  aagaaagct  agcctgctg  cctgcaggg  2400
atgctgctt  agaaccctg  ggcacctaa  agccatgag  ccagcgagg  tgacgtgga  2460
gcgtcggag  ccatgtacg  ctgtgacat  tgcggggcg  cctacacca  ggaggtgct  2520
ctgcagaat  accggctgc  ggaccacaa  atccggccg  gcgaggatg  tggctcacg  2580
aagaaggct  agtttatca  gggcagtca  aagtgcaac  tttgttcac  gactttctt  2640
tcggagaac  ggctacggg  gcacctgca  acgcaccgg  gccctgcca  gcactacat  2700
tgtcccatc  gtggtgagc  cttcccttc  ctgctgacg  tcaccgaac  caaggtgac  2760
cacagcaag  gcctggaca  gggcacctg  cgcatctgc  agatgcccc  gcagagcga  2820
gaggagttt  ttgagcact  ccagatgca  cctgacctg  gcaactcac  cacgggctt  2880
cgctgtgtg  tctgcatgc  gacagtcac  tccacgctt  agctcaaga  ccatggcac  2940
ttccacatg  agaagctgg  gggcagctc  gcggcgtcc  cccccaatg  ccaggggct  3000
cagaagctc  acaagtgcg  cctgtgcct  aaggagttc  gcagcaagc  ggacctggt  3060
aagcttgac  tcaatgggc  gccctacgg  ctctgcgcc  gctgcatgg  ccgcagcgc  3120
aacggacag  tgggtggcc  ggccccgcc  gagcccgcc  accggccct  tgccggcct  3180
cgttgcccc  agtgcagtg  caagtttga  agtgccgaa  acctggaga  ccacatgca  3240
gtggaccac  gtgacctca  gccggagac  agtgggccc  ggaaaggca  ccagacatc  3300
ccagtgccc  ggaaaaaga  ataccagtg  atcaagtgc  agatgacct  cgagaacga  3360
agagagatc  aaatccacg  tgccaacca  atgattgag  aaggcatca  ccacgagtg  3420
aagctgtgc  accagatgt  cgactcccc  gccaagctc  tctgtcacc  cattgagca  3480
agcttcgag  gcatgggcg  caccttcaa  tgccccgtg  gtttcacag  cttcgtcca  3540
gccaacaag  tgcagcagc  catctttgc  gtgcacggg  aggaggaca  gatctacga  3600
tgctcacag  gccctcaga  gttcttctt  cagaccgag  tgcagaacc  cacgatgag  3660
cagcacgca  agtgaggga  cgctcaaca  gacacctct  cgcagaagg  ttgccggag  3720
cgccgtggg  agggccatt  gaacattac  tccaatcaa  gtgtcattt  caacccaga  3780
gtaaaactc  aatgatttg  ccatgaggc  ctgctatta  aagcagctg  aaatgaata  3840
taatggcag  gattaaaag  attccatgc  cagtatttt  tattgtcct  ctacagcta  3900
tgtgctttt  gactttccg  cgcagacta  atttctaga  ttagagaaa  ctgcttttt  3960
aggctattg  cctttgttc  ttcatgtat  atattgata  tttttaaaa  agaattagt  4020
tgatttttt  tctttgctt  ttttttttc  ttcttgttt  tcttccccc  caccccccc  4080
cccccttcg  ttaactact  tttaattgc  attctaggt  attgtgcat  gtgatgtga  4140
tgcttggct  ttgtctgaa  atttccttt  aatttttta  ttaaagact  atgctttga  4200
tggatttgc  agttcaccg  acagtgatt  aaactatgt  atgaatat  4248



<210> 9138
<211> 1224
<212> PRT
<213> Homo sapiens
<308> BAA34480
<400> 9138

Met Glu Asp Glu Ser Ile Tyr Thr Cys Asp His Cys Gln Gln Asp Phe 
  1               5                  10                  15
Glu Ser Leu Ala Asp Leu Thr Asp His Arg Ala His Arg Cys Pro Gly 
             20                  25                  30
Asp Gly Asp Asp Asp Pro Gln Leu Ser Trp Val Ala Ser Ser Pro Ser 
         35                  40                  45
Ser Lys Asp Val Ala Ser Pro Thr Gln Met Ile Gly Asp Gly Cys Asp 
     50                  55                  60
Leu Gly Leu Gly Glu Glu Glu Gly Gly Thr Gly Leu Pro Tyr Pro Cys 
 65                  70                  75                  80
Gln Phe Cys Asp Lys Ser Phe Ile Arg Leu Ser Tyr Leu Lys Arg His 
                 85                  90                  95
Glu Gln Ile His Ser Asp Lys Leu Pro Phe Lys Cys Thr Tyr Cys Ser 
             100                105                110
Arg Leu Phe Lys His Lys Arg Ser Arg Asp Arg His Ile Lys Leu His 
         115                120                125
Thr Gly Asp Lys Lys Tyr His Cys His Glu Cys Glu Ala Ala Phe Ser 
     130                135                140
Arg Ser Asp His Leu Lys Ile His Leu Lys Thr His Ser Ser Ser Lys 
 145                150                155                160
Pro Phe Lys Cys Thr Val Cys Lys Arg Gly Phe Ser Ser Thr Ser Ser 
                 165                170                175
Leu Gln Ser His Met Gln Ala His Lys Lys Asn Lys Glu His Leu Ala 
             180                185                190
Lys Ser Glu Lys Glu Ala Lys Lys Asp Asp Phe Met Cys Asp Tyr Cys 
         195                200                205
Glu Asp Thr Phe Ser Gln Thr Glu Glu Leu Glu Lys His Val Leu Thr 
     210                215                220
Arg His Pro Gln Leu Ser Glu Lys Ala Asp Leu Gln Cys Ile His Cys 
 225                230                235                240
Pro Glu Val Phe Val Asp Glu Asn Thr Leu Leu Ala His Ile His Gln 
                 245                250                255
Ala His Ala Asn Gln Lys His Lys Cys Pro Met Cys Pro Glu Gln Phe 
             260                265                270
Ser Ser Val Glu Gly Val Tyr Cys His Leu Asp Ser His Arg Gln Pro 
         275                280                285
Asp Ser Ser Asn His Ser Val Ser Pro Asp Pro Val Leu Gly Ser Val 
     290                295                300
Ala Ser Met Ser Ser Ala Thr Pro Asp Ser Ser Ala Ser Val Glu Arg 
 305                310                315                320
Gly Ser Thr Pro Asp Ser Thr Leu Lys Pro Leu Arg Gly Gln Lys Lys 
                 325                330                335
Met Arg Asp Asp Gly Gln Gly Trp Thr Lys Val Val Tyr Ser Cys Pro 
             340                345                350
Tyr Cys Ser Lys Arg Asp Phe Asn Ser Leu Ala Val Leu Glu Ile His 
         355                360                365
Leu Lys Thr Ile His Ala Asp Lys Pro Gln Gln Ser His Thr Cys Gln 
     370                375                380
Ile Cys Leu Asp Ser Met Pro Thr Leu Tyr Asn Leu Asn Glu His Val 
 385                390                395                400
Arg Lys Leu His Lys Asn His Ala Tyr Pro Val Met Gln Phe Gly Asn 
                 405                410                415
Ile Ser Ala Phe His Cys Asn Tyr Cys Pro Glu Met Phe Ala Asp Ile 
             420                425                430
Asn Ser Leu Gln Glu His Ile Arg Val Ser His Cys Gly Pro Asn Ala 
         435                440                445
Asn Pro Ser Asp Gly Asn Asn Ala Phe Phe Cys Asn Gln Cys Ser Met 
     450                455                460
Gly Phe Leu Thr Glu Ser Ser Leu Thr Glu His Ile Gln Gln Ala His 
 465                470                475                480
Cys Ser Val Gly Ser Ala Lys Leu Glu Ser Pro Val Val Gln Pro Thr 
                 485                490                495
Gln Ser Phe Met Glu Val Tyr Ser Cys Pro Tyr Cys Thr Asn Ser Pro 
             500                505                510
Ile Phe Gly Ser Ile Leu Lys Leu Thr Lys His Ile Lys Glu Asn His 
         515                520                525
Lys Asn Ile Pro Leu Ala His Ser Lys Lys Ser Lys Ala Glu Gln Ser 
     530                535                540
Pro Val Ser Ser Asp Val Glu Val Ser Ser Pro Lys Arg Gln Arg Leu 
 545                550                555                560
Ser Ala Ser Ala Asn Ser Ile Ser Asn Gly Glu Tyr Pro Cys Asn Gln 
                 565                570                575
Cys Asp Leu Lys Phe Ser Asn Phe Glu Ser Phe Gln Thr His Leu Lys 
             580                585                590
Leu His Leu Glu Leu Leu Leu Arg Lys Gln Ala Cys Pro Gln Cys Lys 
         595                600                605
Glu Asp Phe Asp Ser Gln Glu Ser Leu Leu Gln His Leu Thr Val His 
     610                615                620
Tyr Met Thr Thr Ser Thr His Tyr Val Cys Glu Ser Cys Asp Lys Gln 
 625                630                635                640
Phe Ser Ser Val Asp Asp Leu Gln Lys His Leu Leu Asp Met His Thr 
                 645                650                655
Phe Val Leu Tyr His Cys Thr Leu Cys Gln Glu Val Phe Asp Ser Lys 
             660                665                670
Val Ser Ile Gln Val His Leu Ala Val Lys His Ser Asn Glu Lys Lys 
         675                680                685
Met Tyr Arg Cys Thr Ala Cys Asn Trp Asp Phe Arg Lys Glu Ala Asp 
     690                695                700
Leu Gln Val His Val Lys His Ser His Leu Gly Asn Pro Ala Lys Ala 
 705                710                715                720
His Lys Cys Ile Phe Cys Gly Glu Thr Phe Ser Thr Glu Val Glu Leu 
                 725                730                735
Gln Cys His Ile Thr Thr His Ser Lys Lys Tyr Asn Cys Lys Phe Cys 
             740                745                750
Ser Lys Ala Phe His Ala Ile Ile Leu Leu Glu Lys His Leu Arg Glu 
         755                760                765
Lys His Cys Val Phe Asp Ala Ala Thr Glu Asn Gly Thr Ala Asn Gly 
     770                775                780
Val Pro Pro Met Ala Thr Lys Lys Ala Glu Pro Ala Asp Leu Gln Gly 
 785                790                795                800
Met Leu Leu Lys Asn Pro Glu Ala Pro Asn Ser His Glu Ala Ser Glu 
                 805                810                815
Asp Asp Val Asp Ala Ser Glu Pro Met Tyr Gly Cys Asp Ile Cys Gly 
             820                825                830
Ala Ala Tyr Thr Met Glu Val Leu Leu Gln Asn His Arg Leu Arg Asp 
         835                840                845
His Asn Ile Arg Pro Gly Glu Asp Asp Gly Ser Arg Lys Lys Ala Glu 
     850                855                860
Phe Ile Lys Gly Ser His Lys Cys Asn Val Cys Ser Arg Thr Phe Phe 
 865                870                875                880
Ser Glu Asn Gly Leu Arg Glu His Leu Gln Thr His Arg Gly Pro Ala 
                 885                890                895
Lys His Tyr Met Cys Pro Ile Cys Gly Glu Arg Phe Pro Ser Leu Leu 
             900                905                910
Thr Leu Thr Glu His Lys Val Thr His Ser Lys Ser Leu Asp Thr Gly 
         915                920                925
Thr Cys Arg Ile Cys Lys Met Pro Leu Gln Ser Glu Glu Glu Phe Ile 
     930                935                940
Glu His Cys Gln Met His Pro Asp Leu Arg Asn Ser Leu Thr Gly Phe 
 945                950                955                960
Arg Cys Val Val Cys Met Gln Thr Val Thr Ser Thr Leu Glu Leu Lys 
                 965                970                975
Ile His Gly Thr Phe His Met Gln Lys Leu Ala Gly Ser Ser Ala Ala 
             980                985                990
Ser Ser Pro Asn Gly Gln Gly Leu Gln Lys Leu Tyr Lys Cys Ala Leu 
         995                1000                1005
Cys Leu Lys Glu Phe Arg Ser Lys Gln Asp Leu Val Lys Leu Asp Val 
     1010                1015                1020
Asn Gly Leu Pro Tyr Gly Leu Cys Ala Gly Cys Met Ala Arg Ser Ala 
 1025                1030                1035                1040
Asn Gly Gln Val Gly Gly Leu Ala Pro Pro Glu Pro Ala Asp Arg Pro 
                 1045                1050                1055
Cys Ala Gly Leu Arg Cys Pro Glu Cys Ser Val Lys Phe Glu Ser Ala 
             1060                1065                1070
Glu Asp Leu Glu Ser His Met Gln Val Asp His Arg Asp Leu Thr Pro 
         1075                1080                1085
Glu Thr Ser Gly Pro Arg Lys Gly Thr Gln Thr Ser Pro Val Pro Arg 
     1090                1095                1100
Lys Lys Thr Tyr Gln Cys Ile Lys Cys Gln Met Thr Phe Glu Asn Glu 
 1105                1110                1115                1120
Arg Glu Ile Gln Ile His Val Ala Asn His Met Ile Glu Glu Gly Ile 
                 1125                1130                1135
Asn His Glu Cys Lys Leu Cys Asn Gln Met Phe Asp Ser Pro Ala Lys 
             1140                1145                1150
Leu Leu Cys His Leu Ile Glu His Ser Phe Glu Gly Met Gly Gly Thr 
         1155                1160                1165
Phe Lys Cys Pro Val Cys Phe Thr Val Phe Val Gln Ala Asn Lys Leu 
     1170                1175                1180
Gln Gln His Ile Phe Ala Val His Gly Gln Glu Asp Lys Ile Tyr Asp 
 1185                1190                1195                1200
Cys Ser Gln Cys Pro Gln Lys Phe Phe Phe Gln Thr Glu Leu Gln Asn 
                 1205                1210                1215
His Thr Met Ser Gln His Ala Gln 
             1220



<210> 9139
<211> 4665
<212> DNA
<213> Rattus norvegicus
<308> U92564
<400> 9139

attgcttgc  tcctagggg  cagggctgt  ctgagcacg  cacaccaat  caagcttca  60
aaacaccta  gggcagttg  agaggggga  gcctcggac  tctcgctgg  ctgggattc  120
tctgtggca  cagcgggag  cctagaagg  gagtcagag  gtgatcgga  atccagccg  180
gcgctggaa  acaggaaca  cgtgacaag  caagaggag  gaaacgagg  cgatgaaga  240
gtggaagat  agtcaattt  cacctgcga  cactgtcag  aggacttcg  gtctctggc  300
gacctgacg  accaccggg  ccaccgctg  cctggagat  gtgatgacg  cccacagct  360
tcctgggtg  cttcatctc  ctccagcaa  gatgttgcg  cacccacgc  gatgatcgg  420
gatggttgt  accttggcc  cggcgagga  gaaggcggc  ccggcctgc  gtacccttg  480
cagttctgc  acaagtcct  catccgcct  agctacttg  agaggcatg  acagatcca  540
agcgacaag  tgccgttca  gtgcacctt  tgcagccgc  tcttcaaac  caagaggag  600
cgggaccgg  acatcaagc  gcacacagg  gacaagaag  accactgcc  cgagtgcga  660
gcggctttc  cccgcaggg  ccacctcaa  atccacctg  agacccaca  ctccagcaa  720
ccgttcaag  gcagcgtgt  caaacgcgg  ttctcctcc  ccagctccc  gcagagcca  780
atgcaggcc  acaagaaga  taaggaaca  ctggctaag  cagagaagg  agccaagaa  840
gacgacttc  tgtgtgact  ctgcgagga  acctttagc  agacagaag  gctggagaa  900
catgtgctt  ccctccacc  gcagctctc  gagaaggcg  acctccagt  tatccactg  960
cccgaggtc  ttgtcgacg  gagcacgct  ctggcccac  tccaccaag  tcacgccaa  1020
cagaaacac  agtgcccca  gtgccctga  cagttctcc  ccgtggagg  tgtgtactg  1080
cacctggac  gccaccggc  gcctgattc  agcaatcac  gtgtcagcc  cgaccccgt  1140
ctgggcagt  tggcttcca  gagcagtgc  acacctgac  cgacgcccg  ccccgtgct  1200
ggcagtgtg  cttccatga  cagtgctac  cctgactcg  gcgcctctg  ggagcgcgg  1260
tccacgcca  actccacct  gaagccgct  agggggcag  agaagatgc  ggatgacgg  1320
cagagctgg  ccaaggttg  ctacagctg  ccctactgt  ctaagcggg  ctttaccag  1380
ctggctgtg  tagagattc  tctgaagac  attcacgcg  acaaacctc  gcagagtca  1440
acgtgtcag  tttgcctgg  ctccatgcc  acgctctac  acctcaacg  gcatgtgcg  1500
aagctgcac  agagccacg  ttaccccgt  atgcaattc  gcaacatct  cgccttcca  1560
tgcaactac  gccccgaga  gttcgcgga  atcaacagc  tgcaggagc  catccgagt  1620
tcgcactgt  gccccaatg  caacccccc  gacgggaac  atgctttct  ctgtaacca  1680
tgttctatg  gctttctca  tgaatcctc  ctcacagag  acatccaac  ggcacactg  1740
agtgtgggg  gcaccaagc  ggagtctcc  gttatccag  ccacacagt  cttcatgga  1800
gtctactcc  gcccttact  taccaactc  cctatcttt  gctccatcc  gaagctcac  1860
aagcacatc  aagagaacc  caagaacat  ccgttggca  acagcaaga  gtccaaggc  1920
gagcagagt  cggtctcct  tgacgtcga  gtgtcttcc  cgaaacgac  gcgcctctc  1980
gggagtgcc  actccatct  taacggcga  tacccctgc  atcagtgcg  cctcaagtt  2040
tccaacttc  agagcttcc  gacccactt  aagctgcac  tggagctgc  gctccggaa  2100
caggcctgc  cccagtgca  agaggactt  gactctcag  agtccctcc  gcagcatct  2160
accgtgcac  acatgacca  gtccaccca  tacgtctgc  agagctgtg  caagcagtt  2220
tcctcagtg  acgacctgc  gaagcacct  ctggacatg  acacctttg  gctatacca  2280
tgcaccctg  gtcaggagg  cttcgactc  aaggtgtcc  tccaggtgc  cctggccgt  2340
aagcacagc  acgagaaga  gatgtaccg  tgcaccgcc  gcaactggg  cttccgcaa  2400
gaggctgac  tgcaggtgc  cgtcaagca  agtcacctc  gcaacccgg  caaggccca  2460
aagtgcatc  tctgtggtg  gaccttcag  accgaggtg  agctccagt  ccacatcac  2520
acgcacagc  agaagtaca  ttgcaggtt  tgcagcaaa  ccttccacg  cgtcctcct  2580
ctggagaag  accttcggg  gaagcattg  gtgtttgac  cagctgcag  gaatggcac  2640
gccaacggg  tgcccccca  ctccaccaa  aaggcagag  ccgccgacc  gcagggcat  2700
ctgctcaag  accctgagg  accgaacag  cacgaggcc  gtgaggacg  tgtggatgc  2760
tcagagccc  tgtacggct  tgacatctg  ggtgcagcc  acaccatgg  ggtgctgct  2820
cagaaccac  gactccggg  tcataacat  cggcccgga  aggacgatg  ctcacgcaa  2880
aaggcagag  tcataaagg  cagccacaa  tgtaacgtg  gctctcgga  tttcttctc  2940
gagaacggg  tccgggaac  cctgcagac  caccggggc  ctgccaagc  ctacatgtg  3000
cccatctgt  gcgagcgct  cccctcgct  ctgacgctc  ctgagcaca  ggtgaccca  3060
agcaagagt  tggacacag  cacctgtcg  atctgcaaa  tgcccctgc  gagtgagga  3120
gagtttatc  agcactgcc  gatgcaccc  gacttgcgg  actccctca  tggtttccg  3180
tgtgtggtc  gtatgcaga  tgtcacctc  accctggag  tcaagatcc  tggcacctt  3240
cacatgcag  agctggctg  cagctcagc  gcttcctcc  ccaatggcc  ggggctgca  3300
aagctctac  agtgcgccc  gtgcctcaa  gagttccgt  gcaagcagg  cctggtcag  3360
cttgacgtc  atgggctgc  ctatggcct  tgtgccggc  gcatggccc  tagtgccaa  3420
ggacaggtg  gtggcctgg  cccacccga  cctgccgac  ggccctgcg  tggcctccg  3480
tgccctgaa  gtaacgtga  gtttgagag  gctgaggac  tggagagcc  catgcaggt  3540
gaccaccgt  atcttaccc  agagaccag  gggccccgg  aaggtgccc  gacgtcacc  3600
gtgccccgg  agaagacgt  ccagtgcat  aagtgccag  tgaccttcg  gaacgagag  3660
gagatccag  tccacgtcg  caaccacat  atcgaggaa  gcatcaacc  tgagtgtaa  3720
ctgtgcaac  agatgttcg  ctccccagc  aagctcctt  gtcacctca  cgaacacag  3780
ttcgagggc  tgggtggta  tttcaagtg  cccgtgtgc  tcacagtct  cgtccaggc  3840
aacaagctg  aacagcaca  cttcgccgt  cacgggcag  aggacaaaa  ctacgactg  3900
tcgcagtgc  cacagaagt  tttcttcca  acagagttg  agaaccaca  gatgagcca  3960
cacgcacag  gagggacct  gcgacagga  acctctccg  agaaggctt  ccggagacg  4020
cgtggggag  gccatttga  cattacatc  aatcaaagt  tcatttgca  cccagatgt  4080
aaactctaa  gatttggcc  tgaggcgct  ctattataa  cagctggaa  tgaatatta  4140
tggcagaga  taaaagtat  ccatgctca  tgtttttta  tgtcctgct  cagctagtg  4200
gcttttaga  ttttcgccg  agactacat  tctagtgtt  gagaaacct  cttttttga  4260
gctattgtc  tttgttcct  catgtatta  attgatagt  ttttttaaa  gattagtgt  4320
atttttttt  cttcttttc  atttctttc  ttcttgttt  tctttctcc  ccttcagtt  4380
actactttt  aattgaaat  ctaggtaat  gtgcatcgt  atgtgattg  ttggctatt  4440
tctgaatat  tccttttaa  tttttaatt  aagactaat  ctttgattg  atttgccag  4500
tcaccggac  gtgattaaa  ctctgtaat  aaaataatc  gtttccgtg  aactggatg  4560
tctgctttt  aatgtgact  gatctgact  cagtaacta  ttcagctca  taaagggaa  4620
ccatgcgtt  acccccaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  4665



<210> 9140
<211> 1186
<212> PRT
<213> Rattus norvegicus
<308> AAB58646
<400> 9140

Met Ile Gly Asp Gly Cys Asp Leu Gly Leu Gly Glu Glu Glu Gly Gly 
  1               5                  10                  15
Thr Gly Leu Pro Tyr Pro Cys Gln Phe Cys Asp Lys Ser Phe Ile Arg 
             20                  25                  30
Leu Ser Tyr Leu Lys Arg His Glu Gln Ile His Ser Asp Lys Leu Pro 
         35                  40                  45
Phe Lys Cys Thr Phe Cys Ser Arg Leu Phe Lys His Lys Arg Ser Arg 
     50                  55                  60
Asp Arg His Ile Lys Leu His Thr Gly Asp Lys Lys Tyr His Cys His 
 65                  70                  75                  80
Glu Cys Glu Ala Ala Phe Ser Arg Arg Asp His Leu Lys Ile His Leu 
                 85                  90                  95
Lys Thr His Ser Ser Ser Lys Pro Phe Lys Cys Ser Val Cys Lys Arg 
             100                105                110
Gly Phe Ser Ser Thr Ser Ser Leu Gln Ser His Met Gln Ala His Lys 
         115                120                125
Lys Asn Lys Glu His Leu Ala Lys Ser Glu Lys Glu Ala Lys Lys Asp 
     130                135                140
Asp Phe Met Cys Asp Tyr Cys Glu Asp Thr Phe Ser Gln Thr Glu Glu 
 145                150                155                160
Leu Glu Lys His Val Leu Thr Leu His Pro Gln Leu Ser Glu Lys Ala 
                 165                170                175
Asp Leu Gln Cys Ile His Cys Pro Glu Val Phe Val Asp Glu Ser Thr 
             180                185                190
Leu Leu Ala His Ile His Gln Ala His Ala Asn Gln Lys His Lys Cys 
         195                200                205
Pro Met Cys Pro Glu Gln Phe Ser Ser Val Glu Gly Val Tyr Cys His 
     210                215                220
Leu Asp Ser His Arg Gln Pro Asp Ser Ser Asn His Ser Val Ser Pro 
 225                230                235                240
Asp Pro Val Leu Gly Ser Val Ala Ser Met Ser Ser Ala Thr Pro Asp 
                 245                250                255
Ser Thr Pro Asp Pro Val Leu Gly Ser Val Ala Ser Met Ser Ser Ala 
             260                265                270
Thr Pro Asp Ser Ser Ala Ser Val Glu Arg Gly Ser Thr Pro Asp Ser 
         275                280                285
Thr Leu Lys Pro Leu Arg Gly Gln Lys Lys Met Arg Asp Asp Gly Gln 
     290                295                300
Ser Trp Ser Lys Val Val Tyr Ser Cys Pro Tyr Cys Ser Lys Arg Asp 
 305                310                315                320
Phe Thr Ser Leu Ala Val Leu Glu Ile His Leu Lys Thr Ile His Ala 
                 325                330                335
Asp Lys Pro Gln Gln Ser His Thr Cys Gln Ile Cys Leu Asp Ser Met 
             340                345                350
Pro Thr Leu Tyr Asn Leu Asn Glu His Val Arg Lys Leu His Lys Ser 
         355                360                365
His Ala Tyr Pro Val Met Gln Phe Gly Asn Ile Ser Ala Phe His Cys 
     370                375                380
Asn Tyr Cys Pro Glu Met Phe Ala Asp Ile Asn Ser Leu Gln Glu His 
 385                390                395                400
Ile Arg Val Ser His Cys Gly Pro Asn Ala Asn Pro Pro Asp Gly Asn 
                 405                410                415
Asn Ala Phe Phe Cys Asn Gln Cys Ser Met Gly Phe Leu Thr Glu Ser 
             420                425                430
Ser Leu Thr Glu His Ile Gln Gln Ala His Cys Ser Val Gly Ser Thr 
         435                440                445
Lys Leu Glu Ser Pro Val Ile Gln Pro Thr Gln Ser Phe Met Glu Val 
     450                455                460
Tyr Ser Cys Pro Tyr Cys Thr Asn Ser Pro Ile Phe Gly Ser Ile Leu 
 465                470                475                480
Lys Leu Thr Lys His Ile Lys Glu Asn His Lys Asn Ile Pro Leu Ala 
                 485                490                495
His Ser Lys Lys Ser Lys Ala Glu Gln Ser Pro Val Ser Ser Asp Val 
             500                505                510
Glu Val Ser Ser Pro Lys Arg Gln Arg Leu Ser Gly Ser Ala Asn Ser 
         515                520                525
Ile Ser Asn Gly Glu Tyr Pro Cys Asn Gln Cys Asp Leu Lys Phe Ser 
     530                535                540
Asn Phe Glu Ser Phe Gln Thr His Leu Lys Leu His Leu Glu Leu Leu 
 545                550                555                560
Leu Arg Lys Gln Ala Cys Pro Gln Cys Lys Glu Asp Phe Asp Ser Gln 
                 565                570                575
Glu Ser Leu Leu Gln His Leu Thr Val His Tyr Met Thr Thr Ser Thr 
             580                585                590
His Tyr Val Cys Glu Ser Cys Asp Lys Gln Phe Ser Ser Val Asp Asp 
         595                600                605
Leu Gln Lys His Leu Leu Asp Met His Thr Phe Val Leu Tyr His Cys 
     610                615                620
Thr Leu Cys Gln Glu Val Phe Asp Ser Lys Val Ser Ile Gln Val His 
 625                630                635                640
Leu Ala Val Lys His Ser Asn Glu Lys Lys Met Tyr Arg Cys Thr Ala 
                 645                650                655
Cys Asn Trp Asp Phe Arg Lys Glu Ala Asp Leu Gln Val His Val Lys 
             660                665                670
His Ser His Leu Gly Asn Pro Ala Lys Ala His Lys Cys Ile Phe Cys 
         675                680                685
Gly Glu Thr Phe Ser Thr Glu Val Glu Leu Gln Cys His Ile Thr Thr 
     690                695                700
His Ser Lys Lys Tyr Asn Cys Arg Phe Cys Ser Lys Ala Phe His Ala 
 705                710                715                720
Val Leu Leu Leu Glu Lys His Leu Arg Glu Lys His Cys Val Phe Asp 
                 725                730                735
Pro Ala Ala Glu Asn Gly Thr Ala Asn Gly Val Pro Pro Thr Ser Thr 
             740                745                750
Lys Lys Ala Glu Pro Ala Asp Leu Gln Gly Met Leu Leu Lys Asn Pro 
         755                760                765
Glu Ala Pro Asn Ser His Glu Ala Ser Glu Asp Asp Val Asp Ala Ser 
     770                775                780
Glu Pro Met Tyr Gly Cys Asp Ile Cys Gly Ala Ala Tyr Thr Met Glu 
 785                790                795                800
Val Leu Leu Gln Asn His Arg Leu Arg Asp His Asn Ile Arg Pro Gly 
                 805                810                815
Glu Asp Asp Gly Ser Arg Lys Lys Ala Glu Phe Ile Lys Gly Ser His 
             820                825                830
Lys Cys Asn Val Cys Ser Arg Thr Phe Phe Ser Glu Asn Gly Leu Arg 
         835                840                845
Glu His Leu Gln Thr His Arg Gly Pro Ala Lys His Tyr Met Cys Pro 
     850                855                860
Ile Cys Gly Glu Arg Phe Pro Ser Leu Leu Thr Leu Thr Glu His Lys 
 865                870                875                880
Val Thr His Ser Lys Ser Leu Asp Thr Gly Thr Cys Arg Ile Cys Lys 
                 885                890                895
Met Pro Leu Gln Ser Glu Glu Glu Phe Ile Glu His Cys Gln Met His 
             900                905                910
Pro Asp Leu Arg Asn Ser Leu Thr Gly Phe Arg Cys Val Val Cys Met 
         915                920                925
Gln Thr Val Thr Ser Thr Leu Glu Leu Lys Ile His Gly Thr Phe His 
     930                935                940
Met Gln Lys Leu Ala Gly Ser Ser Ala Ala Ser Ser Pro Asn Gly Gln 
 945                950                955                960
Gly Leu Gln Lys Leu Tyr Lys Cys Ala Leu Cys Leu Lys Glu Phe Arg 
                 965                970                975
Ser Lys Gln Asp Leu Val Arg Leu Asp Val Asn Gly Leu Pro Tyr Gly 
             980                985                990
Leu Cys Ala Gly Cys Met Ala Arg Ser Ala Asn Gly Gln Val Gly Gly 
         995                1000                1005
Leu Ala Pro Pro Glu Pro Ala Asp Arg Pro Cys Ala Gly Leu Arg Cys 
     1010                1015                1020
Pro Glu Cys Asn Val Lys Phe Glu Ser Ala Glu Asp Leu Glu Ser His 
 1025                1030                1035                1040
Met Gln Val Asp His Arg Asp Leu Thr Pro Glu Thr Ser Gly Pro Arg 
                 1045                1050                1055
Lys Gly Ala Gln Thr Ser Pro Val Pro Arg Lys Lys Thr Tyr Gln Cys 
             1060                1065                1070
Ile Lys Cys Gln Met Thr Phe Glu Asn Glu Arg Glu Ile Gln Ile His 
         1075                1080                1085
Val Ala Asn His Met Ile Glu Glu Gly Ile Asn His Glu Cys Lys Leu 
     1090                1095                1100
Cys Asn Gln Met Phe Asp Ser Pro Ala Lys Leu Leu Cys His Leu Ile 
 1105                1110                1115                1120
Glu His Ser Phe Glu Gly Met Gly Gly Thr Phe Lys Cys Pro Val Cys 
                 1125                1130                1135
Phe Thr Val Phe Val Gln Ala Asn Lys Leu Gln Gln His Ile Phe Ala 
             1140                1145                1150
Val His Gly Gln Glu Asp Lys Ile Tyr Asp Cys Ser Gln Cys Pro Gln 
         1155                1160                1165
Lys Phe Phe Phe Gln Thr Glu Leu Gln Asn His Thr Met Ser Gln His 
     1170                1175                1180
Ala Gln 
 1185



<210> 9141
<211> 4248
<212> DNA
<213> Homo sapiens
<308> AB018303
<400> 9141

atggaggat  aatcaattt  cacctgcga  cactgtcag  aggacttcg  gtctctggc  60
gacctgacg  accaccggg  ccaccgctg  cctggagat  gtgatgacg  cccacaact  120
tcctgggtg  cctcgtctc  ctccagcaa  gatgttgcg  cacccacgc  gatgatcgg  180
gatggttgt  acctcggcc  cggcgagga  gaagggggc  cgggcctgc  atacccttg  240
cagttctgc  acaagtcct  catccgctt  agctacttg  agaggcacg  gcagatcca  300
agcgacaag  tgccgttca  gtgcaccta  tgcagccgc  tcttcaagc  caagaggag  360
cgcgaccgg  acatcaagc  gcatacggg  gacaagaag  atcactgcc  cgagtgcga  420
gcagccttc  cccgcagcg  ccacctcaa  atccacctg  agacccaca  ctccagcaa  480
cccttcaag  gcactgtgt  caagcgcgg  ttctcctcc  ccagctcgc  gcagagcca  540
atgcaggcc  acaaaaaga  caaggagca  ctggccaag  cggagaagg  agccaagaa  600
gacgacttc  tgtgcgact  ctgcgagga  accttcagc  agacggagg  gctggagaa  660
cacgtgctc  cccgccacc  gcagctgtc  gagaaggcg  acctgcagt  cattcactg  720
cctgaggtc  tcgtcgacg  gaacacact  ctcgcccat  tccaccaag  ccacgccaa  780
cagaaacac  agtgcccca  gtgccctga  cagttctcc  cagtggaag  tgtctactg  840
cacctggac  gccaccggc  gcccgactc  agcaaccac  gtgtcagtc  cgaccctgt  900
ctgggcagc  tggcctcca  gagcagcgc  acacccgac  ccagcgcct  tgtggagcg  960
ggctccacc  cggactcca  cttgaagcc  ctgcggggg  agaagaaga  gcgggatga  1020
gggcagggc  ggaccaagg  ggtctatag  tgcccctat  gttccaagc  ggactttaa  1080
agcctggcc  tgctggaga  ccacctgaa  accatccac  cggacaagc  ccagcagag  1140
cacacatgt  agatctgcc  ggactccat  cccaccctc  acaacctca  cgagcacgt  1200
cgcaagctg  acaagaacc  tgcctaccc  gtgatgcag  ttggcaaca  ctctgcctt  1260
cactgcaac  actgccccg  gatgttcgc  gacatcaat  gcctgcagg  gcacatccg  1320
gtctcccac  gcggcccca  cgccaaccc  tctgacggt  ataatgctt  cttctgcaa  1380
cagtgctcc  tgggtttcc  tactgagtc  tccctcacc  agcacatcc  gcaggccca  1440
tgcagtgtg  gcagtgcca  actagagtc  ccggtggtg  agcccacgc  gtccttcat  1500
gaggtctat  cctgcccct  ctgcaccaa  tcccccatc  ttggctcca  cctgaaact  1560
accaagcac  tcaaggaga  ccacaagaa  attccactg  cccacagca  gaagtccaa  1620
gccgagcag  gcccagtct  gtccgatgt  gaggtgtct  ccccgaagc  gcagcggct  1680
tcagcaagc  ccaactcca  ctccaatgg  gagtatcct  gcaatcaat  cgacctcaa  1740
ttctccaac  ttgagagct  ccagaccca  ctgaagctg  acctggagc  gctgctgcg  1800
aagcaagcg  gcccccagt  caaagagga  tttgactcc  aggagtccc  cctgcagca  1860
ctgacagtg  attacatga  cacgtcgac  cactatgtg  gcgagagct  cgacaagca  1920
ttttcctcg  tggatgacc  gcagaagca  ctgctggac  tgcacacct  tgtgttgta  1980
cactgcacc  tgtgtcagg  ggtcttcga  tccaaggtg  ccatccagg  gcacctggc  2040
gtgaagcac  gcaatgaga  gaagatgta  cgctgcacg  cctgcaact  ggacttccg  2100
aaggaggct  acctgcagg  gcacgtcaa  cacagccac  tgggcaacc  ggccaaggc  2160
cacaagtgc  tcttctgtg  ggagacctt  agcaccgag  tggagctgc  gtgccacat  2220
accacacac  gcaagaagt  taactgtaa  ttctgcagc  aggccttcc  cgccatcat  2280
ctgctggag  agcacctgc  ggagaagca  tgtgtgttt  atgctgcga  cgagaacgg  2340
acggccaat  gggtacccc  aatggccac  aagaaagct  agcctgctg  cctgcaggg  2400
atgctgctt  agaaccctg  ggcacctaa  agccatgag  ccagcgagg  tgacgtgga  2460
gcgtcggag  ccatgtacg  ctgtgacat  tgcggggcg  cctacacca  ggaggtgct  2520
ctgcagaat  accggctgc  ggaccacaa  atccggccg  gcgaggatg  tggctcacg  2580
aagaaggct  agtttatca  gggcagtca  aagtgcaac  tttgttcac  gactttctt  2640
tcggagaac  ggctacggg  gcacctgca  acgcaccgg  gccctgcca  gcactacat  2700
tgtcccatc  gtggtgagc  cttcccttc  ctgctgacg  tcaccgaac  caaggtgac  2760
cacagcaag  gcctggaca  gggcacctg  cgcatctgc  agatgcccc  gcagagcga  2820
gaggagttt  ttgagcact  ccagatgca  cctgacctg  gcaactcac  cacgggctt  2880
cgctgtgtg  tctgcatgc  gacagtcac  tccacgctt  agctcaaga  ccatggcac  2940
ttccacatg  agaagctgg  gggcagctc  gcggcgtcc  cccccaatg  ccaggggct  3000
cagaagctc  acaagtgcg  cctgtgcct  aaggagttc  gcagcaagc  ggacctggt  3060
aagcttgac  tcaatgggc  gccctacgg  ctctgcgcc  gctgcatgg  ccgcagcgc  3120
aacggacag  tgggtggcc  ggccccgcc  gagcccgcc  accggccct  tgccggcct  3180
cgttgcccc  agtgcagtg  caagtttga  agtgccgaa  acctggaga  ccacatgca  3240
gtggaccac  gtgacctca  gccggagac  agtgggccc  ggaaaggca  ccagacatc  3300
ccagtgccc  ggaaaaaga  ataccagtg  atcaagtgc  agatgacct  cgagaacga  3360
agagagatc  aaatccacg  tgccaacca  atgattgag  aaggcatca  ccacgagtg  3420
aagctgtgc  accagatgt  cgactcccc  gccaagctc  tctgtcacc  cattgagca  3480
agcttcgag  gcatgggcg  caccttcaa  tgccccgtg  gtttcacag  cttcgtcca  3540
gccaacaag  tgcagcagc  catctttgc  gtgcacggg  aggaggaca  gatctacga  3600
tgctcacag  gccctcaga  gttcttctt  cagaccgag  tgcagaacc  cacgatgag  3660
cagcacgca  agtgaggga  cgctcaaca  gacacctct  cgcagaagg  ttgccggag  3720
cgccgtggg  agggccatt  gaacattac  tccaatcaa  gtgtcattt  caacccaga  3780
gtaaaactc  aatgatttg  ccatgaggc  ctgctatta  aagcagctg  aaatgaata  3840
taatggcag  gattaaaag  attccatgc  cagtatttt  tattgtcct  ctacagcta  3900
tgtgctttt  gactttccg  cgcagacta  atttctaga  ttagagaaa  ctgcttttt  3960
aggctattg  cctttgttc  ttcatgtat  atattgata  tttttaaaa  agaattagt  4020
tgatttttt  tctttgctt  ttttttttc  ttcttgttt  tcttccccc  caccccccc  4080
cccccttcg  ttaactact  tttaattgc  attctaggt  attgtgcat  gtgatgtga  4140
tgcttggct  ttgtctgaa  atttccttt  aatttttta  ttaaagact  atgctttga  4200
tggatttgc  agttcaccg  acagtgatt  aaactatgt  atgaatat  4248



<210> 9142
<211> 1224
<212> PRT
<213> Homo sapiens
<308> BAA34480
<400> 9142

Met Glu Asp Glu Ser Ile Tyr Thr Cys Asp His Cys Gln Gln Asp Phe 
  1               5                  10                  15
Glu Ser Leu Ala Asp Leu Thr Asp His Arg Ala His Arg Cys Pro Gly 
             20                  25                  30
Asp Gly Asp Asp Asp Pro Gln Leu Ser Trp Val Ala Ser Ser Pro Ser 
         35                  40                  45
Ser Lys Asp Val Ala Ser Pro Thr Gln Met Ile Gly Asp Gly Cys Asp 
     50                  55                  60
Leu Gly Leu Gly Glu Glu Glu Gly Gly Thr Gly Leu Pro Tyr Pro Cys 
 65                  70                  75                  80
Gln Phe Cys Asp Lys Ser Phe Ile Arg Leu Ser Tyr Leu Lys Arg His 
                 85                  90                  95
Glu Gln Ile His Ser Asp Lys Leu Pro Phe Lys Cys Thr Tyr Cys Ser 
             100                105                110
Arg Leu Phe Lys His Lys Arg Ser Arg Asp Arg His Ile Lys Leu His 
         115                120                125
Thr Gly Asp Lys Lys Tyr His Cys His Glu Cys Glu Ala Ala Phe Ser 
     130                135                140
Arg Ser Asp His Leu Lys Ile His Leu Lys Thr His Ser Ser Ser Lys 
 145                150                155                160
Pro Phe Lys Cys Thr Val Cys Lys Arg Gly Phe Ser Ser Thr Ser Ser 
                 165                170                175
Leu Gln Ser His Met Gln Ala His Lys Lys Asn Lys Glu His Leu Ala 
             180                185                190
Lys Ser Glu Lys Glu Ala Lys Lys Asp Asp Phe Met Cys Asp Tyr Cys 
         195                200                205
Glu Asp Thr Phe Ser Gln Thr Glu Glu Leu Glu Lys His Val Leu Thr 
     210                215                220
Arg His Pro Gln Leu Ser Glu Lys Ala Asp Leu Gln Cys Ile His Cys 
 225                230                235                240
Pro Glu Val Phe Val Asp Glu Asn Thr Leu Leu Ala His Ile His Gln 
                 245                250                255
Ala His Ala Asn Gln Lys His Lys Cys Pro Met Cys Pro Glu Gln Phe 
             260                265                270
Ser Ser Val Glu Gly Val Tyr Cys His Leu Asp Ser His Arg Gln Pro 
         275                280                285
Asp Ser Ser Asn His Ser Val Ser Pro Asp Pro Val Leu Gly Ser Val 
     290                295                300
Ala Ser Met Ser Ser Ala Thr Pro Asp Ser Ser Ala Ser Val Glu Arg 
 305                310                315                320
Gly Ser Thr Pro Asp Ser Thr Leu Lys Pro Leu Arg Gly Gln Lys Lys 
                 325                330                335
Met Arg Asp Asp Gly Gln Gly Trp Thr Lys Val Val Tyr Ser Cys Pro 
             340                345                350
Tyr Cys Ser Lys Arg Asp Phe Asn Ser Leu Ala Val Leu Glu Ile His 
         355                360                365
Leu Lys Thr Ile His Ala Asp Lys Pro Gln Gln Ser His Thr Cys Gln 
     370                375                380
Ile Cys Leu Asp Ser Met Pro Thr Leu Tyr Asn Leu Asn Glu His Val 
 385                390                395                400
Arg Lys Leu His Lys Asn His Ala Tyr Pro Val Met Gln Phe Gly Asn 
                 405                410                415
Ile Ser Ala Phe His Cys Asn Tyr Cys Pro Glu Met Phe Ala Asp Ile 
             420                425                430
Asn Ser Leu Gln Glu His Ile Arg Val Ser His Cys Gly Pro Asn Ala 
         435                440                445
Asn Pro Ser Asp Gly Asn Asn Ala Phe Phe Cys Asn Gln Cys Ser Met 
     450                455                460
Gly Phe Leu Thr Glu Ser Ser Leu Thr Glu His Ile Gln Gln Ala His 
 465                470                475                480
Cys Ser Val Gly Ser Ala Lys Leu Glu Ser Pro Val Val Gln Pro Thr 
                 485                490                495
Gln Ser Phe Met Glu Val Tyr Ser Cys Pro Tyr Cys Thr Asn Ser Pro 
             500                505                510
Ile Phe Gly Ser Ile Leu Lys Leu Thr Lys His Ile Lys Glu Asn His 
         515                520                525
Lys Asn Ile Pro Leu Ala His Ser Lys Lys Ser Lys Ala Glu Gln Ser 
     530                535                540
Pro Val Ser Ser Asp Val Glu Val Ser Ser Pro Lys Arg Gln Arg Leu 
 545                550                555                560
Ser Ala Ser Ala Asn Ser Ile Ser Asn Gly Glu Tyr Pro Cys Asn Gln 
                 565                570                575
Cys Asp Leu Lys Phe Ser Asn Phe Glu Ser Phe Gln Thr His Leu Lys 
             580                585                590
Leu His Leu Glu Leu Leu Leu Arg Lys Gln Ala Cys Pro Gln Cys Lys 
         595                600                605
Glu Asp Phe Asp Ser Gln Glu Ser Leu Leu Gln His Leu Thr Val His 
     610                615                620
Tyr Met Thr Thr Ser Thr His Tyr Val Cys Glu Ser Cys Asp Lys Gln 
 625                630                635                640
Phe Ser Ser Val Asp Asp Leu Gln Lys His Leu Leu Asp Met His Thr 
                 645                650                655
Phe Val Leu Tyr His Cys Thr Leu Cys Gln Glu Val Phe Asp Ser Lys 
             660                665                670
Val Ser Ile Gln Val His Leu Ala Val Lys His Ser Asn Glu Lys Lys 
         675                680                685
Met Tyr Arg Cys Thr Ala Cys Asn Trp Asp Phe Arg Lys Glu Ala Asp 
     690                695                700
Leu Gln Val His Val Lys His Ser His Leu Gly Asn Pro Ala Lys Ala 
 705                710                715                720
His Lys Cys Ile Phe Cys Gly Glu Thr Phe Ser Thr Glu Val Glu Leu 
                 725                730                735
Gln Cys His Ile Thr Thr His Ser Lys Lys Tyr Asn Cys Lys Phe Cys 
             740                745                750
Ser Lys Ala Phe His Ala Ile Ile Leu Leu Glu Lys His Leu Arg Glu 
         755                760                765
Lys His Cys Val Phe Asp Ala Ala Thr Glu Asn Gly Thr Ala Asn Gly 
     770                775                780
Val Pro Pro Met Ala Thr Lys Lys Ala Glu Pro Ala Asp Leu Gln Gly 
 785                790                795                800
Met Leu Leu Lys Asn Pro Glu Ala Pro Asn Ser His Glu Ala Ser Glu 
                 805                810                815
Asp Asp Val Asp Ala Ser Glu Pro Met Tyr Gly Cys Asp Ile Cys Gly 
             820                825                830
Ala Ala Tyr Thr Met Glu Val Leu Leu Gln Asn His Arg Leu Arg Asp 
         835                840                845
His Asn Ile Arg Pro Gly Glu Asp Asp Gly Ser Arg Lys Lys Ala Glu 
     850                855                860
Phe Ile Lys Gly Ser His Lys Cys Asn Val Cys Ser Arg Thr Phe Phe 
 865                870                875                880
Ser Glu Asn Gly Leu Arg Glu His Leu Gln Thr His Arg Gly Pro Ala 
                 885                890                895
Lys His Tyr Met Cys Pro Ile Cys Gly Glu Arg Phe Pro Ser Leu Leu 
             900                905                910
Thr Leu Thr Glu His Lys Val Thr His Ser Lys Ser Leu Asp Thr Gly 
         915                920                925
Thr Cys Arg Ile Cys Lys Met Pro Leu Gln Ser Glu Glu Glu Phe Ile 
     930                935                940
Glu His Cys Gln Met His Pro Asp Leu Arg Asn Ser Leu Thr Gly Phe 
 945                950                955                960
Arg Cys Val Val Cys Met Gln Thr Val Thr Ser Thr Leu Glu Leu Lys 
                 965                970                975
Ile His Gly Thr Phe His Met Gln Lys Leu Ala Gly Ser Ser Ala Ala 
             980                985                990
Ser Ser Pro Asn Gly Gln Gly Leu Gln Lys Leu Tyr Lys Cys Ala Leu 
         995                1000                1005
Cys Leu Lys Glu Phe Arg Ser Lys Gln Asp Leu Val Lys Leu Asp Val 
     1010                1015                1020
Asn Gly Leu Pro Tyr Gly Leu Cys Ala Gly Cys Met Ala Arg Ser Ala 
 1025                1030                1035                1040
Asn Gly Gln Val Gly Gly Leu Ala Pro Pro Glu Pro Ala Asp Arg Pro 
                 1045                1050                1055
Cys Ala Gly Leu Arg Cys Pro Glu Cys Ser Val Lys Phe Glu Ser Ala 
             1060                1065                1070
Glu Asp Leu Glu Ser His Met Gln Val Asp His Arg Asp Leu Thr Pro 
         1075                1080                1085
Glu Thr Ser Gly Pro Arg Lys Gly Thr Gln Thr Ser Pro Val Pro Arg 
     1090                1095                1100
Lys Lys Thr Tyr Gln Cys Ile Lys Cys Gln Met Thr Phe Glu Asn Glu 
 1105                1110                1115                1120
Arg Glu Ile Gln Ile His Val Ala Asn His Met Ile Glu Glu Gly Ile 
                 1125                1130                1135
Asn His Glu Cys Lys Leu Cys Asn Gln Met Phe Asp Ser Pro Ala Lys 
             1140                1145                1150
Leu Leu Cys His Leu Ile Glu His Ser Phe Glu Gly Met Gly Gly Thr 
         1155                1160                1165
Phe Lys Cys Pro Val Cys Phe Thr Val Phe Val Gln Ala Asn Lys Leu 
     1170                1175                1180
Gln Gln His Ile Phe Ala Val His Gly Gln Glu Asp Lys Ile Tyr Asp 
 1185                1190                1195                1200
Cys Ser Gln Cys Pro Gln Lys Phe Phe Phe Gln Thr Glu Leu Gln Asn 
                 1205                1210                1215
His Thr Met Ser Gln His Ala Gln 
             1220



<210> 9143
<211> 4665
<212> DNA
<213> Rattus norvegicus
<308> U92564
<400> 9143

attgcttgc  tcctagggg  cagggctgt  ctgagcacg  cacaccaat  caagcttca  60
aaacaccta  gggcagttg  agaggggga  gcctcggac  tctcgctgg  ctgggattc  120
tctgtggca  cagcgggag  cctagaagg  gagtcagag  gtgatcgga  atccagccg  180
gcgctggaa  acaggaaca  cgtgacaag  caagaggag  gaaacgagg  cgatgaaga  240
gtggaagat  agtcaattt  cacctgcga  cactgtcag  aggacttcg  gtctctggc  300
gacctgacg  accaccggg  ccaccgctg  cctggagat  gtgatgacg  cccacagct  360
tcctgggtg  cttcatctc  ctccagcaa  gatgttgcg  cacccacgc  gatgatcgg  420
gatggttgt  accttggcc  cggcgagga  gaaggcggc  ccggcctgc  gtacccttg  480
cagttctgc  acaagtcct  catccgcct  agctacttg  agaggcatg  acagatcca  540
agcgacaag  tgccgttca  gtgcacctt  tgcagccgc  tcttcaaac  caagaggag  600
cgggaccgg  acatcaagc  gcacacagg  gacaagaag  accactgcc  cgagtgcga  660
gcggctttc  cccgcaggg  ccacctcaa  atccacctg  agacccaca  ctccagcaa  720
ccgttcaag  gcagcgtgt  caaacgcgg  ttctcctcc  ccagctccc  gcagagcca  780
atgcaggcc  acaagaaga  taaggaaca  ctggctaag  cagagaagg  agccaagaa  840
gacgacttc  tgtgtgact  ctgcgagga  acctttagc  agacagaag  gctggagaa  900
catgtgctt  ccctccacc  gcagctctc  gagaaggcg  acctccagt  tatccactg  960
cccgaggtc  ttgtcgacg  gagcacgct  ctggcccac  tccaccaag  tcacgccaa  1020
cagaaacac  agtgcccca  gtgccctga  cagttctcc  ccgtggagg  tgtgtactg  1080
cacctggac  gccaccggc  gcctgattc  agcaatcac  gtgtcagcc  cgaccccgt  1140
ctgggcagt  tggcttcca  gagcagtgc  acacctgac  cgacgcccg  ccccgtgct  1200
ggcagtgtg  cttccatga  cagtgctac  cctgactcg  gcgcctctg  ggagcgcgg  1260
tccacgcca  actccacct  gaagccgct  agggggcag  agaagatgc  ggatgacgg  1320
cagagctgg  ccaaggttg  ctacagctg  ccctactgt  ctaagcggg  ctttaccag  1380
ctggctgtg  tagagattc  tctgaagac  attcacgcg  acaaacctc  gcagagtca  1440
acgtgtcag  tttgcctgg  ctccatgcc  acgctctac  acctcaacg  gcatgtgcg  1500
aagctgcac  agagccacg  ttaccccgt  atgcaattc  gcaacatct  cgccttcca  1560
tgcaactac  gccccgaga  gttcgcgga  atcaacagc  tgcaggagc  catccgagt  1620
tcgcactgt  gccccaatg  caacccccc  gacgggaac  atgctttct  ctgtaacca  1680
tgttctatg  gctttctca  tgaatcctc  ctcacagag  acatccaac  ggcacactg  1740
agtgtgggg  gcaccaagc  ggagtctcc  gttatccag  ccacacagt  cttcatgga  1800
gtctactcc  gcccttact  taccaactc  cctatcttt  gctccatcc  gaagctcac  1860
aagcacatc  aagagaacc  caagaacat  ccgttggca  acagcaaga  gtccaaggc  1920
gagcagagt  cggtctcct  tgacgtcga  gtgtcttcc  cgaaacgac  gcgcctctc  1980
gggagtgcc  actccatct  taacggcga  tacccctgc  atcagtgcg  cctcaagtt  2040
tccaacttc  agagcttcc  gacccactt  aagctgcac  tggagctgc  gctccggaa  2100
caggcctgc  cccagtgca  agaggactt  gactctcag  agtccctcc  gcagcatct  2160
accgtgcac  acatgacca  gtccaccca  tacgtctgc  agagctgtg  caagcagtt  2220
tcctcagtg  acgacctgc  gaagcacct  ctggacatg  acacctttg  gctatacca  2280
tgcaccctg  gtcaggagg  cttcgactc  aaggtgtcc  tccaggtgc  cctggccgt  2340
aagcacagc  acgagaaga  gatgtaccg  tgcaccgcc  gcaactggg  cttccgcaa  2400
gaggctgac  tgcaggtgc  cgtcaagca  agtcacctc  gcaacccgg  caaggccca  2460
aagtgcatc  tctgtggtg  gaccttcag  accgaggtg  agctccagt  ccacatcac  2520
acgcacagc  agaagtaca  ttgcaggtt  tgcagcaaa  ccttccacg  cgtcctcct  2580
ctggagaag  accttcggg  gaagcattg  gtgtttgac  cagctgcag  gaatggcac  2640
gccaacggg  tgcccccca  ctccaccaa  aaggcagag  ccgccgacc  gcagggcat  2700
ctgctcaag  accctgagg  accgaacag  cacgaggcc  gtgaggacg  tgtggatgc  2760
tcagagccc  tgtacggct  tgacatctg  ggtgcagcc  acaccatgg  ggtgctgct  2820
cagaaccac  gactccggg  tcataacat  cggcccgga  aggacgatg  ctcacgcaa  2880
aaggcagag  tcataaagg  cagccacaa  tgtaacgtg  gctctcgga  tttcttctc  2940
gagaacggg  tccgggaac  cctgcagac  caccggggc  ctgccaagc  ctacatgtg  3000
cccatctgt  gcgagcgct  cccctcgct  ctgacgctc  ctgagcaca  ggtgaccca  3060
agcaagagt  tggacacag  cacctgtcg  atctgcaaa  tgcccctgc  gagtgagga  3120
gagtttatc  agcactgcc  gatgcaccc  gacttgcgg  actccctca  tggtttccg  3180
tgtgtggtc  gtatgcaga  tgtcacctc  accctggag  tcaagatcc  tggcacctt  3240
cacatgcag  agctggctg  cagctcagc  gcttcctcc  ccaatggcc  ggggctgca  3300
aagctctac  agtgcgccc  gtgcctcaa  gagttccgt  gcaagcagg  cctggtcag  3360
cttgacgtc  atgggctgc  ctatggcct  tgtgccggc  gcatggccc  tagtgccaa  3420
ggacaggtg  gtggcctgg  cccacccga  cctgccgac  ggccctgcg  tggcctccg  3480
tgccctgaa  gtaacgtga  gtttgagag  gctgaggac  tggagagcc  catgcaggt  3540
gaccaccgt  atcttaccc  agagaccag  gggccccgg  aaggtgccc  gacgtcacc  3600
gtgccccgg  agaagacgt  ccagtgcat  aagtgccag  tgaccttcg  gaacgagag  3660
gagatccag  tccacgtcg  caaccacat  atcgaggaa  gcatcaacc  tgagtgtaa  3720
ctgtgcaac  agatgttcg  ctccccagc  aagctcctt  gtcacctca  cgaacacag  3780
ttcgagggc  tgggtggta  tttcaagtg  cccgtgtgc  tcacagtct  cgtccaggc  3840
aacaagctg  aacagcaca  cttcgccgt  cacgggcag  aggacaaaa  ctacgactg  3900
tcgcagtgc  cacagaagt  tttcttcca  acagagttg  agaaccaca  gatgagcca  3960
cacgcacag  gagggacct  gcgacagga  acctctccg  agaaggctt  ccggagacg  4020
cgtggggag  gccatttga  cattacatc  aatcaaagt  tcatttgca  cccagatgt  4080
aaactctaa  gatttggcc  tgaggcgct  ctattataa  cagctggaa  tgaatatta  4140
tggcagaga  taaaagtat  ccatgctca  tgtttttta  tgtcctgct  cagctagtg  4200
gcttttaga  ttttcgccg  agactacat  tctagtgtt  gagaaacct  cttttttga  4260
gctattgtc  tttgttcct  catgtatta  attgatagt  ttttttaaa  gattagtgt  4320
atttttttt  cttcttttc  atttctttc  ttcttgttt  tctttctcc  ccttcagtt  4380
actactttt  aattgaaat  ctaggtaat  gtgcatcgt  atgtgattg  ttggctatt  4440
tctgaatat  tccttttaa  tttttaatt  aagactaat  ctttgattg  atttgccag  4500
tcaccggac  gtgattaaa  ctctgtaat  aaaataatc  gtttccgtg  aactggatg  4560
tctgctttt  aatgtgact  gatctgact  cagtaacta  ttcagctca  taaagggaa  4620
ccatgcgtt  acccccaaa  aaaaaaaaa  aaaaaaaaa  aaaaa  4665



<210> 9144
<211> 1186
<212> PRT
<213> Rattus norvegicus
<308> AAB58646
<400> 9144

Met Ile Gly Asp Gly Cys Asp Leu Gly Leu Gly Glu Glu Glu Gly Gly 
  1               5                  10                  15
Thr Gly Leu Pro Tyr Pro Cys Gln Phe Cys Asp Lys Ser Phe Ile Arg 
             20                  25                  30
Leu Ser Tyr Leu Lys Arg His Glu Gln Ile His Ser Asp Lys Leu Pro 
         35                  40                  45
Phe Lys Cys Thr Phe Cys Ser Arg Leu Phe Lys His Lys Arg Ser Arg 
     50                  55                  60
Asp Arg His Ile Lys Leu His Thr Gly Asp Lys Lys Tyr His Cys His 
 65                  70                  75                  80
Glu Cys Glu Ala Ala Phe Ser Arg Arg Asp His Leu Lys Ile His Leu 
                 85                  90                  95
Lys Thr His Ser Ser Ser Lys Pro Phe Lys Cys Ser Val Cys Lys Arg 
             100                105                110
Gly Phe Ser Ser Thr Ser Ser Leu Gln Ser His Met Gln Ala His Lys 
         115                120                125
Lys Asn Lys Glu His Leu Ala Lys Ser Glu Lys Glu Ala Lys Lys Asp 
     130                135                140
Asp Phe Met Cys Asp Tyr Cys Glu Asp Thr Phe Ser Gln Thr Glu Glu 
 145                150                155                160
Leu Glu Lys His Val Leu Thr Leu His Pro Gln Leu Ser Glu Lys Ala 
                 165                170                175
Asp Leu Gln Cys Ile His Cys Pro Glu Val Phe Val Asp Glu Ser Thr 
             180                185                190
Leu Leu Ala His Ile His Gln Ala His Ala Asn Gln Lys His Lys Cys 
         195                200                205
Pro Met Cys Pro Glu Gln Phe Ser Ser Val Glu Gly Val Tyr Cys His 
     210                215                220
Leu Asp Ser His Arg Gln Pro Asp Ser Ser Asn His Ser Val Ser Pro 
 225                230                235                240
Asp Pro Val Leu Gly Ser Val Ala Ser Met Ser Ser Ala Thr Pro Asp 
                 245                250                255
Ser Thr Pro Asp Pro Val Leu Gly Ser Val Ala Ser Met Ser Ser Ala 
             260                265                270
Thr Pro Asp Ser Ser Ala Ser Val Glu Arg Gly Ser Thr Pro Asp Ser 
         275                280                285
Thr Leu Lys Pro Leu Arg Gly Gln Lys Lys Met Arg Asp Asp Gly Gln 
     290                295                300
Ser Trp Ser Lys Val Val Tyr Ser Cys Pro Tyr Cys Ser Lys Arg Asp 
 305                310                315                320
Phe Thr Ser Leu Ala Val Leu Glu Ile His Leu Lys Thr Ile His Ala 
                 325                330                335
Asp Lys Pro Gln Gln Ser His Thr Cys Gln Ile Cys Leu Asp Ser Met 
             340                345                350
Pro Thr Leu Tyr Asn Leu Asn Glu His Val Arg Lys Leu His Lys Ser 
         355                360                365
His Ala Tyr Pro Val Met Gln Phe Gly Asn Ile Ser Ala Phe His Cys 
     370                375                380
Asn Tyr Cys Pro Glu Met Phe Ala Asp Ile Asn Ser Leu Gln Glu His 
 385                390                395                400
Ile Arg Val Ser His Cys Gly Pro Asn Ala Asn Pro Pro Asp Gly Asn 
                 405                410                415
Asn Ala Phe Phe Cys Asn Gln Cys Ser Met Gly Phe Leu Thr Glu Ser 
             420                425                430
Ser Leu Thr Glu His Ile Gln Gln Ala His Cys Ser Val Gly Ser Thr 
         435                440                445
Lys Leu Glu Ser Pro Val Ile Gln Pro Thr Gln Ser Phe Met Glu Val 
     450                455                460
Tyr Ser Cys Pro Tyr Cys Thr Asn Ser Pro Ile Phe Gly Ser Ile Leu 
 465                470                475                480
Lys Leu Thr Lys His Ile Lys Glu Asn His Lys Asn Ile Pro Leu Ala 
                 485                490                495
His Ser Lys Lys Ser Lys Ala Glu Gln Ser Pro Val Ser Ser Asp Val 
             500                505                510
Glu Val Ser Ser Pro Lys Arg Gln Arg Leu Ser Gly Ser Ala Asn Ser 
         515                520                525
Ile Ser Asn Gly Glu Tyr Pro Cys Asn Gln Cys Asp Leu Lys Phe Ser 
     530                535                540
Asn Phe Glu Ser Phe Gln Thr His Leu Lys Leu His Leu Glu Leu Leu 
 545                550                555                560
Leu Arg Lys Gln Ala Cys Pro Gln Cys Lys Glu Asp Phe Asp Ser Gln 
                 565                570                575
Glu Ser Leu Leu Gln His Leu Thr Val His Tyr Met Thr Thr Ser Thr 
             580                585                590
His Tyr Val Cys Glu Ser Cys Asp Lys Gln Phe Ser Ser Val Asp Asp 
         595                600                605
Leu Gln Lys His Leu Leu Asp Met His Thr Phe Val Leu Tyr His Cys 
     610                615                620
Thr Leu Cys Gln Glu Val Phe Asp Ser Lys Val Ser Ile Gln Val His 
 625                630                635                640
Leu Ala Val Lys His Ser Asn Glu Lys Lys Met Tyr Arg Cys Thr Ala 
                 645                650                655
Cys Asn Trp Asp Phe Arg Lys Glu Ala Asp Leu Gln Val His Val Lys 
             660                665                670
His Ser His Leu Gly Asn Pro Ala Lys Ala His Lys Cys Ile Phe Cys 
         675                680                685
Gly Glu Thr Phe Ser Thr Glu Val Glu Leu Gln Cys His Ile Thr Thr 
     690                695                700
His Ser Lys Lys Tyr Asn Cys Arg Phe Cys Ser Lys Ala Phe His Ala 
 705                710                715                720
Val Leu Leu Leu Glu Lys His Leu Arg Glu Lys His Cys Val Phe Asp 
                 725                730                735
Pro Ala Ala Glu Asn Gly Thr Ala Asn Gly Val Pro Pro Thr Ser Thr 
             740                745                750
Lys Lys Ala Glu Pro Ala Asp Leu Gln Gly Met Leu Leu Lys Asn Pro 
         755                760                765
Glu Ala Pro Asn Ser His Glu Ala Ser Glu Asp Asp Val Asp Ala Ser 
     770                775                780
Glu Pro Met Tyr Gly Cys Asp Ile Cys Gly Ala Ala Tyr Thr Met Glu 
 785                790                795                800
Val Leu Leu Gln Asn His Arg Leu Arg Asp His Asn Ile Arg Pro Gly 
                 805                810                815
Glu Asp Asp Gly Ser Arg Lys Lys Ala Glu Phe Ile Lys Gly Ser His 
             820                825                830
Lys Cys Asn Val Cys Ser Arg Thr Phe Phe Ser Glu Asn Gly Leu Arg 
         835                840                845
Glu His Leu Gln Thr His Arg Gly Pro Ala Lys His Tyr Met Cys Pro 
     850                855                860
Ile Cys Gly Glu Arg Phe Pro Ser Leu Leu Thr Leu Thr Glu His Lys 
 865                870                875                880
Val Thr His Ser Lys Ser Leu Asp Thr Gly Thr Cys Arg Ile Cys Lys 
                 885                890                895
Met Pro Leu Gln Ser Glu Glu Glu Phe Ile Glu His Cys Gln Met His 
             900                905                910
Pro Asp Leu Arg Asn Ser Leu Thr Gly Phe Arg Cys Val Val Cys Met 
         915                920                925
Gln Thr Val Thr Ser Thr Leu Glu Leu Lys Ile His Gly Thr Phe His 
     930                935                940
Met Gln Lys Leu Ala Gly Ser Ser Ala Ala Ser Ser Pro Asn Gly Gln 
 945                950                955                960
Gly Leu Gln Lys Leu Tyr Lys Cys Ala Leu Cys Leu Lys Glu Phe Arg 
                 965                970                975
Ser Lys Gln Asp Leu Val Arg Leu Asp Val Asn Gly Leu Pro Tyr Gly 
             980                985                990
Leu Cys Ala Gly Cys Met Ala Arg Ser Ala Asn Gly Gln Val Gly Gly 
         995                1000                1005
Leu Ala Pro Pro Glu Pro Ala Asp Arg Pro Cys Ala Gly Leu Arg Cys 
     1010                1015                1020
Pro Glu Cys Asn Val Lys Phe Glu Ser Ala Glu Asp Leu Glu Ser His 
 1025                1030                1035                1040
Met Gln Val Asp His Arg Asp Leu Thr Pro Glu Thr Ser Gly Pro Arg 
                 1045                1050                1055
Lys Gly Ala Gln Thr Ser Pro Val Pro Arg Lys Lys Thr Tyr Gln Cys 
             1060                1065                1070
Ile Lys Cys Gln Met Thr Phe Glu Asn Glu Arg Glu Ile Gln Ile His 
         1075                1080                1085
Val Ala Asn His Met Ile Glu Glu Gly Ile Asn His Glu Cys Lys Leu 
     1090                1095                1100
Cys Asn Gln Met Phe Asp Ser Pro Ala Lys Leu Leu Cys His Leu Ile 
 1105                1110                1115                1120
Glu His Ser Phe Glu Gly Met Gly Gly Thr Phe Lys Cys Pro Val Cys 
                 1125                1130                1135
Phe Thr Val Phe Val Gln Ala Asn Lys Leu Gln Gln His Ile Phe Ala 
             1140                1145                1150
Val His Gly Gln Glu Asp Lys Ile Tyr Asp Cys Ser Gln Cys Pro Gln 
         1155                1160                1165
Lys Phe Phe Phe Gln Thr Glu Leu Gln Asn His Thr Met Ser Gln His 
     1170                1175                1180
Ala Gln 
 1185



<210> 9145
<211> 4248
<212> DNA
<213> Homo sapiens
<308> AB018303
<400> 9145

atggaggat  aatcaattt  cacctgcga  cactgtcag  aggacttcg  gtctctggc  60
gacctgacg  accaccggg  ccaccgctg  cctggagat  gtgatgacg  cccacaact  120
tcctgggtg  cctcgtctc  ctccagcaa  gatgttgcg  cacccacgc  gatgatcgg  180
gatggttgt  acctcggcc  cggcgagga  gaagggggc  cgggcctgc  atacccttg  240
cagttctgc  acaagtcct  catccgctt  agctacttg  agaggcacg  gcagatcca  300
agcgacaag  tgccgttca  gtgcaccta  tgcagccgc  tcttcaagc  caagaggag  360
cgcgaccgg  acatcaagc  gcatacggg  gacaagaag  atcactgcc  cgagtgcga  420
gcagccttc  cccgcagcg  ccacctcaa  atccacctg  agacccaca  ctccagcaa  480
cccttcaag  gcactgtgt  caagcgcgg  ttctcctcc  ccagctcgc  gcagagcca  540
atgcaggcc  acaaaaaga  caaggagca  ctggccaag  cggagaagg  agccaagaa  600
gacgacttc  tgtgcgact  ctgcgagga  accttcagc  agacggagg  gctggagaa  660
cacgtgctc  cccgccacc  gcagctgtc  gagaaggcg  acctgcagt  cattcactg  720
cctgaggtc  tcgtcgacg  gaacacact  ctcgcccat  tccaccaag  ccacgccaa  780
cagaaacac  agtgcccca  gtgccctga  cagttctcc  cagtggaag  tgtctactg  840
cacctggac  gccaccggc  gcccgactc  agcaaccac  gtgtcagtc  cgaccctgt  900
ctgggcagc  tggcctcca  gagcagcgc  acacccgac  ccagcgcct  tgtggagcg  960
ggctccacc  cggactcca  cttgaagcc  ctgcggggg  agaagaaga  gcgggatga  1020
gggcagggc  ggaccaagg  ggtctatag  tgcccctat  gttccaagc  ggactttaa  1080
agcctggcc  tgctggaga  ccacctgaa  accatccac  cggacaagc  ccagcagag  1140
cacacatgt  agatctgcc  ggactccat  cccaccctc  acaacctca  cgagcacgt  1200
cgcaagctg  acaagaacc  tgcctaccc  gtgatgcag  ttggcaaca  ctctgcctt  1260
cactgcaac  actgccccg  gatgttcgc  gacatcaat  gcctgcagg  gcacatccg  1320
gtctcccac  gcggcccca  cgccaaccc  tctgacggt  ataatgctt  cttctgcaa  1380
cagtgctcc  tgggtttcc  tactgagtc  tccctcacc  agcacatcc  gcaggccca  1440
tgcagtgtg  gcagtgcca  actagagtc  ccggtggtg  agcccacgc  gtccttcat  1500
gaggtctat  cctgcccct  ctgcaccaa  tcccccatc  ttggctcca  cctgaaact  1560
accaagcac  tcaaggaga  ccacaagaa  attccactg  cccacagca  gaagtccaa  1620
gccgagcag  gcccagtct  gtccgatgt  gaggtgtct  ccccgaagc  gcagcggct  1680
tcagcaagc  ccaactcca  ctccaatgg  gagtatcct  gcaatcaat  cgacctcaa  1740
ttctccaac  ttgagagct  ccagaccca  ctgaagctg  acctggagc  gctgctgcg  1800
aagcaagcg  gcccccagt  caaagagga  tttgactcc  aggagtccc  cctgcagca  1860
ctgacagtg  attacatga  cacgtcgac  cactatgtg  gcgagagct  cgacaagca  1920
ttttcctcg  tggatgacc  gcagaagca  ctgctggac  tgcacacct  tgtgttgta  1980
cactgcacc  tgtgtcagg  ggtcttcga  tccaaggtg  ccatccagg  gcacctggc  2040
gtgaagcac  gcaatgaga  gaagatgta  cgctgcacg  cctgcaact  ggacttccg  2100
aaggaggct  acctgcagg  gcacgtcaa  cacagccac  tgggcaacc  ggccaaggc  2160
cacaagtgc  tcttctgtg  ggagacctt  agcaccgag  tggagctgc  gtgccacat  2220
accacacac  gcaagaagt  taactgtaa  ttctgcagc  aggccttcc  cgccatcat  2280
ctgctggag  agcacctgc  ggagaagca  tgtgtgttt  atgctgcga  cgagaacgg  2340
acggccaat  gggtacccc  aatggccac  aagaaagct  agcctgctg  cctgcaggg  2400
atgctgctt  agaaccctg  ggcacctaa  agccatgag  ccagcgagg  tgacgtgga  2460
gcgtcggag  ccatgtacg  ctgtgacat  tgcggggcg  cctacacca  ggaggtgct  2520
ctgcagaat  accggctgc  ggaccacaa  atccggccg  gcgaggatg  tggctcacg  2580
aagaaggct  agtttatca  gggcagtca  aagtgcaac  tttgttcac  gactttctt  2640
tcggagaac  ggctacggg  gcacctgca  acgcaccgg  gccctgcca  gcactacat  2700
tgtcccatc  gtggtgagc  cttcccttc  ctgctgacg  tcaccgaac  caaggtgac  2760
cacagcaag  gcctggaca  gggcacctg  cgcatctgc  agatgcccc  gcagagcga  2820
gaggagttt  ttgagcact  ccagatgca  cctgacctg  gcaactcac  cacgggctt  2880
cgctgtgtg  tctgcatgc  gacagtcac  tccacgctt  agctcaaga  ccatggcac  2940
ttccacatg  agaagctgg  gggcagctc  gcggcgtcc  cccccaatg  ccaggggct  3000
cagaagctc  acaagtgcg  cctgtgcct  aaggagttc  gcagcaagc  ggacctggt  3060
aagcttgac  tcaatgggc  gccctacgg  ctctgcgcc  gctgcatgg  ccgcagcgc  3120
aacggacag  tgggtggcc  ggccccgcc  gagcccgcc  accggccct  tgccggcct  3180
cgttgcccc  agtgcagtg  caagtttga  agtgccgaa  acctggaga  ccacatgca  3240
gtggaccac  gtgacctca  gccggagac  agtgggccc  ggaaaggca  ccagacatc  3300
ccagtgccc  ggaaaaaga  ataccagtg  atcaagtgc  agatgacct  cgagaacga  3360
agagagatc  aaatccacg  tgccaacca  atgattgag  aaggcatca  ccacgagtg  3420
aagctgtgc  accagatgt  cgactcccc  gccaagctc  tctgtcacc  cattgagca  3480
agcttcgag  gcatgggcg  caccttcaa  tgccccgtg  gtttcacag  cttcgtcca  3540
gccaacaag  tgcagcagc  catctttgc  gtgcacggg  aggaggaca  gatctacga  3600
tgctcacag  gccctcaga  gttcttctt  cagaccgag  tgcagaacc  cacgatgag  3660
cagcacgca  agtgaggga  cgctcaaca  gacacctct  cgcagaagg  ttgccggag  3720
cgccgtggg  agggccatt  gaacattac  tccaatcaa  gtgtcattt  caacccaga  3780
gtaaaactc  aatgatttg  ccatgaggc  ctgctatta  aagcagctg  aaatgaata  3840
taatggcag  gattaaaag  attccatgc  cagtatttt  tattgtcct  ctacagcta  3900
tgtgctttt  gactttccg  cgcagacta  atttctaga  ttagagaaa  ctgcttttt  3960
aggctattg  cctttgttc  ttcatgtat  atattgata  tttttaaaa  agaattagt  4020
tgatttttt  tctttgctt  ttttttttc  ttcttgttt  tcttccccc  caccccccc  4080
cccccttcg  ttaactact  tttaattgc  attctaggt  attgtgcat  gtgatgtga  4140
tgcttggct  ttgtctgaa  atttccttt  aatttttta  ttaaagact  atgctttga  4200
tggatttgc  agttcaccg  acagtgatt  aaactatgt  atgaatat  4248



<210> 9146
<211> 1224
<212> PRT
<213> Homo sapiens
<308> BAA34480
<400> 9146

Met Glu Asp Glu Ser Ile Tyr Thr Cys Asp His Cys Gln Gln Asp Phe 
  1               5                  10                  15
Glu Ser Leu Ala Asp Leu Thr Asp His Arg Ala His Arg Cys Pro Gly 
             20                  25                  30
Asp Gly Asp Asp Asp Pro Gln Leu Ser Trp Val Ala Ser Ser Pro Ser 
         35                  40                  45
Ser Lys Asp Val Ala Ser Pro Thr Gln Met Ile Gly Asp Gly Cys Asp 
     50                  55                  60
Leu Gly Leu Gly Glu Glu Glu Gly Gly Thr Gly Leu Pro Tyr Pro Cys 
 65                  70                  75                  80
Gln Phe Cys Asp Lys Ser Phe Ile Arg Leu Ser Tyr Leu Lys Arg His 
                 85                  90                  95
Glu Gln Ile His Ser Asp Lys Leu Pro Phe Lys Cys Thr Tyr Cys Ser 
             100                105                110
Arg Leu Phe Lys His Lys Arg Ser Arg Asp Arg His Ile Lys Leu His 
         115                120                125
Thr Gly Asp Lys Lys Tyr His Cys His Glu Cys Glu Ala Ala Phe Ser 
     130                135                140
Arg Ser Asp His Leu Lys Ile His Leu Lys Thr His Ser Ser Ser Lys 
 145                150                155                160
Pro Phe Lys Cys Thr Val Cys Lys Arg Gly Phe Ser Ser Thr Ser Ser 
                 165                170                175
Leu Gln Ser His Met Gln Ala His Lys Lys Asn Lys Glu His Leu Ala 
             180                185                190
Lys Ser Glu Lys Glu Ala Lys Lys Asp Asp Phe Met Cys Asp Tyr Cys 
         195                200                205
Glu Asp Thr Phe Ser Gln Thr Glu Glu Leu Glu Lys His Val Leu Thr 
     210                215                220
Arg His Pro Gln Leu Ser Glu Lys Ala Asp Leu Gln Cys Ile His Cys 
 225                230                235                240
Pro Glu Val Phe Val Asp Glu Asn Thr Leu Leu Ala His Ile His Gln 
                 245                250                255
Ala His Ala Asn Gln Lys His Lys Cys Pro Met Cys Pro Glu Gln Phe 
             260                265                270
Ser Ser Val Glu Gly Val Tyr Cys His Leu Asp Ser His Arg Gln Pro 
         275                280                285
Asp Ser Ser Asn His Ser Val Ser Pro Asp Pro Val Leu Gly Ser Val 
     290                295                300
Ala Ser Met Ser Ser Ala Thr Pro Asp Ser Ser Ala Ser Val Glu Arg 
 305                310                315                320
Gly Ser Thr Pro Asp Ser Thr Leu Lys Pro Leu Arg Gly Gln Lys Lys 
                 325                330                335
Met Arg Asp Asp Gly Gln Gly Trp Thr Lys Val Val Tyr Ser Cys Pro 
             340                345                350
Tyr Cys Ser Lys Arg Asp Phe Asn Ser Leu Ala Val Leu Glu Ile His 
         355                360                365
Leu Lys Thr Ile His Ala Asp Lys Pro Gln Gln Ser His Thr Cys Gln 
     370                375                380
Ile Cys Leu Asp Ser Met Pro Thr Leu Tyr Asn Leu Asn Glu His Val 
 385                390                395                400
Arg Lys Leu His Lys Asn His Ala Tyr Pro Val Met Gln Phe Gly Asn 
                 405                410                415
Ile Ser Ala Phe His Cys Asn Tyr Cys Pro Glu Met Phe Ala Asp Ile 
             420                425                430
Asn Ser Leu Gln Glu His Ile Arg Val Ser His Cys Gly Pro Asn Ala 
         435                440                445
Asn Pro Ser Asp Gly Asn Asn Ala Phe Phe Cys Asn Gln Cys Ser Met 
     450                455                460
Gly Phe Leu Thr Glu Ser Ser Leu Thr Glu His Ile Gln Gln Ala His 
 465                470                475                480
Cys Ser Val Gly Ser Ala Lys Leu Glu Ser Pro Val Val Gln Pro Thr 
                 485                490                495
Gln Ser Phe Met Glu Val Tyr Ser Cys Pro Tyr Cys Thr Asn Ser Pro 
             500                505                510
Ile Phe Gly Ser Ile Leu Lys Leu Thr Lys His Ile Lys Glu Asn His 
         515                520                525
Lys Asn Ile Pro Leu Ala His Ser Lys Lys Ser Lys Ala Glu Gln Ser 
     530                535                540
Pro Val Ser Ser Asp Val Glu Val Ser Ser Pro Lys Arg Gln Arg Leu 
 545                550                555                560
Ser Ala Ser Ala Asn Ser Ile Ser Asn Gly Glu Tyr Pro Cys Asn Gln 
                 565                570                575
Cys Asp Leu Lys Phe Ser Asn Phe Glu Ser Phe Gln Thr His Leu Lys 
             580                585                590
Leu His Leu Glu Leu Leu Leu Arg Lys Gln Ala Cys Pro Gln Cys Lys 
         595                600                605
Glu Asp Phe Asp Ser Gln Glu Ser Leu Leu Gln His Leu Thr Val His 
     610                615                620
Tyr Met Thr Thr Ser Thr His Tyr Val Cys Glu Ser Cys Asp Lys Gln 
 625                630                635                640
Phe Ser Ser Val Asp Asp Leu Gln Lys His Leu Leu Asp Met His Thr 
                 645                650                655
Phe Val Leu Tyr His Cys Thr Leu Cys Gln Glu Val Phe Asp Ser Lys 
             660                665                670
Val Ser Ile Gln Val His Leu Ala Val Lys His Ser Asn Glu Lys Lys 
         675                680                685
Met Tyr Arg Cys Thr Ala Cys Asn Trp Asp Phe Arg Lys Glu Ala Asp 
     690                695                700
Leu Gln Val His Val Lys His Ser His Leu Gly Asn Pro Ala Lys Ala 
 705                710                715                720
His Lys Cys Ile Phe Cys Gly Glu Thr Phe Ser Thr Glu Val Glu Leu 
                 725                730                735
Gln Cys His Ile Thr Thr His Ser Lys Lys Tyr Asn Cys Lys Phe Cys 
             740                745                750
Ser Lys Ala Phe His Ala Ile Ile Leu Leu Glu Lys His Leu Arg Glu 
         755                760                765
Lys His Cys Val Phe Asp Ala Ala Thr Glu Asn Gly Thr Ala Asn Gly 
     770                775                780
Val Pro Pro Met Ala Thr Lys Lys Ala Glu Pro Ala Asp Leu Gln Gly 
 785                790                795                800
Met Leu Leu Lys Asn Pro Glu Ala Pro Asn Ser His Glu Ala Ser Glu 
                 805                810                815
Asp Asp Val Asp Ala Ser Glu Pro Met Tyr Gly Cys Asp Ile Cys Gly 
             820                825                830
Ala Ala Tyr Thr Met Glu Val Leu Leu Gln Asn His Arg Leu Arg Asp 
         835                840                845
His Asn Ile Arg Pro Gly Glu Asp Asp Gly Ser Arg Lys Lys Ala Glu 
     850                855                860
Phe Ile Lys Gly Ser His Lys Cys Asn Val Cys Ser Arg Thr Phe Phe 
 865                870                875                880
Ser Glu Asn Gly Leu Arg Glu His Leu Gln Thr His Arg Gly Pro Ala 
                 885                890                895
Lys His Tyr Met Cys Pro Ile Cys Gly Glu Arg Phe Pro Ser Leu Leu 
             900                905                910
Thr Leu Thr Glu His Lys Val Thr His Ser Lys Ser Leu Asp Thr Gly 
         915                920                925
Thr Cys Arg Ile Cys Lys Met Pro Leu Gln Ser Glu Glu Glu Phe Ile 
     930                935                940
Glu His Cys Gln Met His Pro Asp Leu Arg Asn Ser Leu Thr Gly Phe 
 945                950                955                960
Arg Cys Val Val Cys Met Gln Thr Val Thr Ser Thr Leu Glu Leu Lys 
                 965                970                975
Ile His Gly Thr Phe His Met Gln Lys Leu Ala Gly Ser Ser Ala Ala 
             980                985                990
Ser Ser Pro Asn Gly Gln Gly Leu Gln Lys Leu Tyr Lys Cys Ala Leu 
         995                1000                1005
Cys Leu Lys Glu Phe Arg Ser Lys Gln Asp Leu Val Lys Leu Asp Val 
     1010                1015                1020
Asn Gly Leu Pro Tyr Gly Leu Cys Ala Gly Cys Met Ala Arg Ser Ala 
 1025                1030                1035                1040
Asn Gly Gln Val Gly Gly Leu Ala Pro Pro Glu Pro Ala Asp Arg Pro 
                 1045                1050                1055
Cys Ala Gly Leu Arg Cys Pro Glu Cys Ser Val Lys Phe Glu Ser Ala 
             1060                1065                1070
Glu Asp Leu Glu Ser His Met Gln Val Asp His Arg Asp Leu Thr Pro 
         1075                1080                1085
Glu Thr Ser Gly Pro Arg Lys Gly Thr Gln Thr Ser Pro Val Pro Arg 
     1090                1095                1100
Lys Lys Thr Tyr Gln Cys Ile Lys Cys Gln Met Thr Phe Glu Asn Glu 
 1105                1110                1115                1120
Arg Glu Ile Gln Ile His Val Ala Asn His Met Ile Glu Glu Gly Ile 
                 1125                1130                1135
Asn His Glu Cys Lys Leu Cys Asn Gln Met Phe Asp Ser Pro Ala Lys 
             1140                1145                1150
Leu Leu Cys His Leu Ile Glu His Ser Phe Glu Gly Met Gly Gly Thr 
         1155                1160                1165
Phe Lys Cys Pro Val Cys Phe Thr Val Phe Val Gln Ala Asn Lys Leu 
     1170                1175                1180
Gln Gln His Ile Phe Ala Val His Gly Gln Glu Asp Lys Ile Tyr Asp 
 1185                1190                1195                1200
Cys Ser Gln Cys Pro Gln Lys Phe Phe Phe Gln Thr Glu Leu Gln Asn 
                 1205                1210                1215
His Thr Met Ser Gln His Ala Gln 
             1220



<210> 9147
<211> 1619
<212> DNA
<213> Rattus norvegicus
<308> U93197
<400> 9147

ggttcgaga  tcggttgaa  aacaggctg  tagttttaa  gcgactcgc  tcaacctgg  60
gacagagtg  aagaacaac  acccccgcc  gcgggagct  gacaggaat  aactatttg  120
aaaggctaa  aatgagatc  tcgatgaag  catcagtct  agccaggtt  ctccaaagc  180
ctgggagga  atccttcag  agtccctgt  ggaacgagt  tcaacgcat  tgatcgaga  240
catctacct  ccagctgcc  agaccatga  ctcaggaac  ttcaacacc  cagtggaca  300
caagcttaa  cagtggact  acaagcagc  tcctaataa  gcagtcgag  ttgcttggg  360
gaccctaca  gacgaattt  cccgcttca  gacagaacc  aaaggaaag  aacacgatg  420
catatttga  aaacttaag  aggctgtga  ggaggagag  atcaagcgg  acaaatgga  480
cgacttcgc  gaagacagc  tgagggtca  ccagcacaa  gctctggag  accggtcca  540
atcagataa  caacagtgg  acgcagcca  ctacttcat  gaagaggca  ttcaaggtc  600
tctcaagga  actgaaaat  ctattgaaa  catgatcgg  ccagactgg  aaaagaggt  660
gatatactg  aagaatcgg  cccaagagc  gtgtgttca  aatgaaacc  agaatgaat  720
ggaaaagat  ctgaaggtt  atgatgaac  cccagctta  cttgcaagt  atgagatta  780
cacagtccg  aagaacctg  aatctcgag  agtcgaagt  gatccaagc  tgattaagg  840
tacttggca  caagtctat  gaagacatt  cctaaaaac  gctctaaat  actgtaacc  900
ttgtcggag  ggtttttat  actaccaga  gcattttat  gactctgag  tggagtgca  960
cgacgtggt  ctgttctgg  gaatacagc  catgctcgc  atcactgcc  acacgctga  1020
gcagcagct  acaaacacc  aagttaggc  gctagagaa  aacgttaaa  aggtattag  1080
agattttgc  gaagacggc  agaagaagg  taaattgct  actggcaaa  gagttcagc  1140
ggcagaaga  ctcaagaaa  ttagagaaa  tcaagaaaa  cttgatgct  tcattgaag  1200
tcttcacca  gagaagtag  cggtgtcaa  atcctgctc  tgttaacac  tctgcatac  1260
tttgaagaa  gaaaacttc  gagtcttgt  ctgcctcct  ttctccagt  ctacccttt  1320
cagtgcaaa  taaagtcat  gggtaaaag  aatgtatgt  tggtacagg  acttaaccc  1380
cagctgccg  gtgagcaga  gaacactgg  aatggcaac  accttctgt  tgcttgtgc  1440
gacaggaaa  actgggaaa  catagttgg  cttgaggct  agtcctcaa  gataaggag  1500
tggctctct  gggccttat  tgtggtggc  ctaatgcga  tcgttatgg  tgttatcag  1560
catttagtg  tagttgctt  ggaataaaa  ggtactatt  taaaaaaaa  aaaaaaaaa  1619



<210> 9148
<211> 317
<212> PRT
<213> Rattus norvegicus
<308> AAB51724
<400> 9148

Met Asn Ser Gly Thr Phe Asn Thr Thr Val Asp Ile Lys Leu Lys Gln 
  1               5                  10                  15
Trp Thr Asp Lys Gln Leu Pro Asn Lys Ala Val Glu Val Ala Trp Glu 
             20                  25                  30
Thr Leu Gln Asp Glu Phe Ser Arg Phe Met Thr Glu Pro Lys Gly Lys 
         35                  40                  45
Glu His Asp Asp Ile Phe Asp Lys Leu Lys Glu Ala Val Lys Glu Glu 
     50                  55                  60
Ser Ile Lys Arg His Lys Trp Asn Asp Phe Ala Glu Asp Ser Leu Arg 
 65                  70                  75                  80
Val Ile Gln His Asn Ala Leu Glu Asp Arg Ser Ile Ser Asp Lys Gln 
                 85                  90                  95
Gln Trp Asp Ala Ala Ile Tyr Phe Met Glu Glu Ala Leu Gln Gly Arg 
             100                105                110
Leu Lys Asp Thr Glu Asn Ala Ile Glu Asn Met Ile Gly Pro Asp Trp 
         115                120                125
Lys Lys Arg Trp Ile Tyr Trp Lys Asn Arg Thr Gln Glu Gln Cys Val 
     130                135                140
His Asn Glu Thr Lys Asn Glu Leu Glu Lys Met Leu Lys Val Asn Asp 
 145                150                155                160
Glu His Pro Ala Tyr Leu Ala Ser Asp Glu Ile Thr Thr Val Arg Lys 
                 165                170                175
Asn Leu Glu Ser Arg Gly Val Glu Val Asp Pro Ser Leu Ile Lys Asp 
             180                185                190
Thr Trp His Gln Val Tyr Arg Arg His Phe Leu Lys Thr Ala Leu Asn 
         195                200                205
His Cys Asn Leu Cys Arg Arg Gly Phe Tyr Tyr Tyr Gln Arg His Phe 
     210                215                220
Ile Asp Ser Glu Leu Glu Cys Asn Asp Val Val Leu Phe Trp Arg Ile 
 225                230                235                240
Gln Arg Met Leu Ala Ile Thr Ala Asn Thr Leu Arg Gln Gln Leu Thr 
                 245                250                255
Asn Thr Glu Val Arg Arg Leu Glu Lys Asn Val Lys Glu Val Leu Glu 
             260                265                270
Asp Phe Ala Glu Asp Gly Glu Lys Lys Val Lys Leu Leu Thr Gly Lys 
         275                280                285
Arg Val Gln Leu Ala Glu Asp Leu Lys Lys Val Arg Glu Ile Gln Glu 
     290                295                300
Lys Leu Asp Ala Phe Ile Glu Ala Leu His Gln Glu Lys 
 305                310                315



<210> 9149
<211> 1338
<212> DNA
<213> Homo sapiens
<308> AK022522
<400> 9149

agagaaaaa  gttaaagag  tattggaag  ttttgctga  gatggtgag  agaagatta  60
attgcttac  ggtaaacgc  ttcaactgg  ggaagacct  aagaaagtt  gagaaattc  120
agaaaaact  gatgctttc  ttgaagctc  tcatcagga  aaataaatt  aaatcgtac  180
cataatcag  tctgcatac  tctgaagaa  aaaaacatc  acgtctttt  tccagcctc  240
ttttcttct  ctgttccac  tttctaaac  tacaataaa  tcatgggat  aaaataatc  300
atgtatgtt  cgggcgctt  aaccatcag  tgcctctcg  atggaagaa  agtggtaat  360
gattaacat  ctattttgt  gtactaaag  gacaaatcg  aataatata  ttggtatgg  420
cattaggtt  agtccttga  gataagaag  ttgttctct  tttgttgtc  tatttgtgg  480
ggcactcgt  taatggatt  actgaggtt  ctcaatgtt  agtttcttt  ccagaaata  540
aatgctagg  gttttgaaa  aaaacttat  tagcaattg  ttaaagtta  caattgtat  600
taaaatcac  gtagcctgc  aaatcattg  atgtgtctg  agtattcta  tcccagaaa  660
tatttgacc  tgataattc  gtttatatt  accacatga  agaaaaatg  gtaacagaa  720
aacccctaa  acaggttaa  ttggattgt  acgttcagt  aaagaaatt  caacccttc  780
tagccagcg  agaaatttg  cttggaagc  aagtcagta  cagcttacc  atttgattc  840
gttgctgtt  tctcactct  tatatccat  tgaaattga  ttattttag  tgttgtata  900
ttacgttag  ctttctgtt  atagtggtt  ttctcctgt  gacagagcc  ccggattat  960
acacaggat  aggaaggtt  aggataatc  attgactaa  ttcatttag  atattatca  1020
acatttcaa  taggtatca  aaaaaggct  tctttcata  gactatttt  aatagaaat  1080
atttcaaca  ttaaagtaa  gttgaccat  cccctctca  ctgaataaa  aaaaattta  1140
ttcaattta  tgcaattta  ttacaatac  accttcaca  cattttcat  tgttttaaa  1200
aaatatttt  taattggct  aaggacatt  aagcaaaga  atgctttct  tacttaaaa  1260
gtctatctc  tttgctgct  tttcactaa  cctttactt  gttaataaa  gtgtccatt  1320
tgtgatgtt  ttgatttt  1338



<210> 9150
<211> 960
<212> PRT
<213> Homo sapiens
<308> O60313
<400> 9150

Met Trp Arg Leu Arg Arg Ala Ala Val Ala Cys Glu Val Cys Gln Ser 
  1               5                  10                  15
Leu Val Lys His Ser Ser Gly Ile Lys Gly Ser Leu Pro Leu Gln Lys 
             20                  25                  30
Leu His Leu Val Ser Arg Ser Ile Tyr His Ser His His Pro Thr Leu 
         35                  40                  45
Lys Leu Gln Arg Pro Gln Leu Arg Thr Ser Phe Gln Gln Phe Ser Ser 
     50                  55                  60
Leu Thr Asn Leu Pro Leu Arg Lys Leu Lys Phe Ser Pro Ile Lys Tyr 
 65                  70                  75                  80
Gly Tyr Gln Pro Arg Arg Asn Phe Trp Pro Ala Arg Leu Ala Thr Arg 
                 85                  90                  95
Leu Leu Lys Leu Arg Tyr Leu Ile Leu Gly Ser Ala Val Gly Gly Gly 
             100                105                110
Tyr Thr Ala Lys Lys Thr Phe Asp Gln Trp Lys Asp Met Ile Pro Asp 
         115                120                125
Leu Ser Glu Tyr Lys Trp Ile Val Pro Asp Ile Val Trp Glu Ile Asp 
     130                135                140
Glu Tyr Ile Asp Phe Glu Lys Ile Arg Lys Ala Leu Pro Asn Ser Glu 
 145                150                155                160
Asp Leu Val Lys Leu Ala Pro Asp Phe Asp Lys Ile Val Glu Ser Leu 
                 165                170                175
Ser Leu Leu Lys Asp Phe Phe Thr Ser Gly Ser Pro Glu Glu Thr Ala 
             180                185                190
Phe Arg Ala Thr Asp Arg Gly Ser Glu Ser Asp Lys His Phe Arg Lys 
         195                200                205
Val Ser Asp Lys Glu Lys Ile Asp Gln Leu Gln Glu Glu Leu Leu His 
     210                215                220
Thr Gln Leu Lys Tyr Gln Arg Ile Leu Glu Arg Leu Glu Lys Glu Asn 
 225                230                235                240
Lys Glu Leu Arg Lys Leu Val Leu Gln Lys Asp Asp Lys Gly Ile His 
                 245                250                255
His Arg Lys Leu Lys Lys Ser Leu Ile Asp Met Tyr Ser Glu Val Leu 
             260                265                270
Asp Val Leu Ser Asp Tyr Asp Ala Ser Tyr Asn Thr Gln Asp His Leu 
         275                280                285
Pro Arg Val Val Val Val Gly Asp Gln Ser Ala Gly Lys Thr Ser Val 
     290                295                300
Leu Glu Met Ile Ala Gln Ala Arg Ile Phe Pro Arg Gly Ser Gly Glu 
 305                310                315                320
Met Met Thr Arg Ser Pro Val Lys Val Thr Leu Ser Glu Gly Pro His 
                 325                330                335
His Val Ala Leu Phe Lys Asp Ser Ser Arg Glu Phe Asp Leu Thr Lys 
             340                345                350
Glu Glu Asp Leu Ala Ala Leu Arg His Glu Ile Glu Leu Arg Met Arg 
         355                360                365
Lys Asn Val Lys Glu Gly Cys Thr Val Ser Pro Glu Thr Ile Ser Leu 
     370                375                380
Asn Val Lys Gly Pro Gly Leu Gln Arg Met Val Leu Val Asp Leu Pro 
 385                390                395                400
Gly Val Ile Asn Thr Val Thr Ser Gly Met Ala Pro Asp Thr Lys Glu 
                 405                410                415
Thr Ile Phe Ser Ile Ser Lys Ala Tyr Met Gln Asn Pro Asn Ala Ile 
             420                425                430
Ile Leu Cys Ile Gln Asp Gly Ser Val Asp Ala Glu Arg Ser Ile Val 
         435                440                445
Thr Asp Leu Val Ser Gln Met Asp Pro His Gly Arg Arg Thr Ile Phe 
     450                455                460
Val Leu Thr Lys Val Asp Leu Ala Glu Lys Asn Val Ala Ser Pro Ser 
 465                470                475                480
Arg Ile Gln Gln Ile Ile Glu Gly Lys Leu Phe Pro Met Lys Ala Leu 
                 485                490                495
Gly Tyr Phe Ala Val Val Thr Gly Lys Gly Asn Ser Ser Glu Ser Ile 
             500                505                510
Glu Ala Ile Arg Glu Tyr Glu Glu Glu Phe Phe Gln Asn Ser Lys Leu 
         515                520                525
Leu Lys Thr Ser Met Leu Lys Ala His Gln Val Thr Thr Arg Asn Leu 
     530                535                540
Ser Leu Ala Val Ser Asp Cys Phe Trp Lys Met Val Arg Glu Ser Val 
 545                550                555                560
Glu Gln Gln Ala Asp Ser Phe Lys Ala Thr Arg Phe Asn Leu Glu Thr 
                 565                570                575
Glu Trp Lys Asn Asn Tyr Pro Arg Leu Arg Glu Leu Asp Arg Asn Glu 
             580                585                590
Leu Phe Glu Lys Ala Lys Asn Glu Ile Leu Asp Glu Val Ile Ser Leu 
         595                600                605
Ser Gln Val Thr Pro Lys His Trp Glu Glu Ile Leu Gln Gln Ser Leu 
     610                615                620
Trp Glu Arg Val Ser Thr His Val Ile Glu Asn Ile Tyr Leu Pro Ala 
 625                630                635                640
Ala Gln Thr Met Asn Ser Gly Thr Phe Asn Thr Thr Val Asp Ile Lys 
                 645                650                655
Leu Lys Gln Trp Thr Asp Lys Gln Leu Pro Asn Lys Ala Val Glu Val 
             660                665                670
Ala Trp Glu Thr Leu Gln Glu Glu Phe Ser Arg Phe Met Thr Glu Pro 
         675                680                685
Lys Gly Lys Glu His Asp Asp Ile Phe Asp Lys Leu Lys Glu Ala Val 
     690                695                700
Lys Glu Glu Ser Ile Lys Arg His Lys Trp Asn Asp Phe Ala Glu Asp 
 705                710                715                720
Ser Leu Arg Val Ile Gln His Asn Ala Leu Glu Asp Arg Ser Ile Ser 
                 725                730                735
Asp Lys Gln Gln Trp Asp Ala Ala Ile Tyr Phe Met Glu Glu Ala Leu 
             740                745                750
Gln Ala Arg Leu Lys Asp Thr Glu Asn Ala Ile Glu Asn Met Val Gly 
         755                760                765
Pro Asp Trp Lys Lys Arg Trp Leu Tyr Trp Lys Asn Arg Thr Gln Glu 
     770                775                780
Gln Cys Val His Asn Glu Thr Lys Asn Glu Leu Glu Lys Met Leu Lys 
 785                790                795                800
Cys Asn Glu Glu His Pro Ala Tyr Leu Ala Ser Asp Glu Ile Thr Thr 
                 805                810                815
Val Arg Lys Asn Leu Glu Ser Arg Gly Val Glu Val Asp Pro Ser Leu 
             820                825                830
Ile Lys Asp Thr Trp His Gln Val Tyr Arg Arg His Phe Leu Lys Thr 
         835                840                845
Ala Leu Asn His Cys Asn Leu Cys Arg Arg Gly Phe Tyr Tyr Tyr Gln 
     850                855                860
Arg His Phe Val Asp Ser Glu Leu Glu Cys Asn Asp Val Val Leu Phe 
 865                870                875                880
Trp Arg Ile Gln Arg Met Leu Ala Ile Thr Ala Asn Thr Leu Arg Gln 
                 885                890                895
Gln Leu Thr Asn Thr Glu Val Arg Arg Leu Glu Lys Asn Val Lys Glu 
             900                905                910
Val Leu Glu Asp Phe Ala Glu Asp Gly Glu Lys Lys Ile Lys Leu Leu 
         915                920                925
Thr Gly Lys Arg Val Gln Leu Ala Glu Asp Leu Lys Lys Val Arg Glu 
     930                935                940
Ile Gln Glu Lys Leu Asp Ala Phe Ile Glu Ala Leu His Gln Glu Lys 
 945                950                955                960



<210> 9151
<211> 3128
<212> DNA
<213> Rattus norvegicus
<308> U94340
<400> 9151

tctgcccat  tgtgcagat  tagagggag  atggcggag  ccacggaga  gctttaccg  60
gtggagtac  ctaagagcg  gcgcgcctc  tgcaagaaa  gcagcgaga  tatccccaa  120
gactcgctc  gcatggcca  catggtgca  tcacccatg  tcgatggaa  agtcccaca  180
tggtatcac  tctcctgct  ctggaaggt  ggccactcc  tccggcagc  tgacacaga  240
gtggacggg  tctctgagc  gcggtggga  gaccagcag  aggtcaaga  gaccgcaga  300
gctggaggc  tggcaggca  aggccagca  ggaggtggc  gcaaggcgg  gaagacgct  360
ggcgacttt  cggcagagt  tgccaagtc  aacaggagc  catgcaagg  ctgcatgga  420
aagatagag  agggtcaga  gcgcctgtc  aagaagatg  tggatccag  gaagccgca  480
ctgggtatg  ttgaccgct  gtaccatcc  acttgcttt  tcaagaacc  ggacgagct  540
ggcttccgg  ctgagtaca  tgccagcca  ctcaagggc  ttagcctcc  ctctgcaga  600
gacaaagaa  ctctgaaga  gcagctccc  gcagtcaag  gtgaaggaa  gagaaaatg  660
gacgaggtg  atggaatag  tgaagtagc  aaaaagaaa  ctaaaaaag  aaaggacaa  720
gagagtagt  aactggaaa  ggcgctcaa  gctcagaac  agctggtct  gaatatcaa  780
gatgagctg  agaaagcct  ctccaccaa  gacctgaag  agttgctca  cttcaacca  840
cagcaagta  catctggag  gtccgcaat  ctggaccga  ttgctgatg  catggcgtt  900
ggggccctt  tgccctgca  ggagtgttc  ggacagctg  tttttaaga  cgacgctta  960
tactgtact  gggatgtca  tgcctggac  aagtgcatg  tcaagacac  gaatcccag  1020
cgaaaggaa  gggtaactc  aaaggaatt  cgagaaata  cctacctca  gaaattaaa  1080
atcaaaaag  aggaccggc  gttccctcc  gagagcagc  ccccagcac  accagcacc  1140
cccgtctcg  tcacctccg  acccacagc  gtgaactcc  ctgcaccag  agacaaacc  1200
ctgtctaac  tgaagatcc  gactcttgg  aagctctcc  agaacaagg  cgaagcaaa  1260
gccatgatt  agaaactcg  aggcaagct  acaggatct  ccaacaagg  ctccttgtg  1320
atcagcact  agaaggagg  ggagaagat  agtaagaag  tggaggaag  gaaagcagc  1380
aatgttcga  tcgtgtgtg  ggacttcct  caggatgtg  ctgcctcag  taagagcct  1440
caagagctg  tctcagccc  tagcttgtc  tcgtggggg  ctgaggtga  ggtagagcc  1500
ggtgaagtg  tggtcccca  ggggaagtc  gctgcaccc  ccaagaaga  caagggtgc  1560
gtcaaggag  aaggtgtca  caagtctga  aagaggatg  aactaactc  gaagggagg  1620
gcagccgtt  atcctgact  tggtctgga  cactctgca  atgtcctgg  gaaaggcgg  1680
aaggtgttc  gtgccacgc  tggcctggt  gacattgtg  aagggacta  ctcctatta  1740
aaactgcaa  ttctggagt  cgacaagga  agcaggtat  ggatcttcc  gtcctgggg  1800
cgagtgggc  cagttatcg  cagtaacaa  cttgagcag  tgccgtcca  agaggatgc  1860
gttgaacac  tcatgaagt  atacgaaga  aagactgga  atgcctggc  ctcgaaaaa  1920
ttcacaaag  atcccaaga  gttctaccc  ctggagatt  actatggcc  ggacgaaga  1980
gcagtaaag  agctggcgg  gaagcctgg  actaagtcg  agctgccga  gccggtgca  2040
gagctcgtc  ggatgatct  cgacgtgga  agcatgaag  aggccttgg  ggagtacga  2100
attgacctt  agaagatgc  cttggggaa  ctgagcaga  ggcagatcc  ggccgccta  2160
tctatcctc  gtgaggtcc  gcaggcagt  tcccaaggc  gcagtgaat  tcagatcct  2220
gatctctcc  atcgcttct  caccctcat  ccccatgac  ttggaatga  gaagccccc  2280
cttctgaac  acacagaca  tgtgcaggc  aaggtggag  tgctggaca  cctcctgga  2340
atcgaggtt  cctatagtc  tctcagggg  gggtctgat  acagcagta  ggaccccat  2400
gatgtcaac  atgagaagc  caaaactga  attaaggtg  ttgacagag  ttctgaaga  2460
gctgaggtc  tcaggaagt  tgtgaagaa  actcacgcg  ccacgcaca  tgcctatga  2520
ctggaagtg  tagacatct  taagataga  cgagaggga  agagccaac  ctacaagcc  2580
ttcaggcag  ttcacaacc  gagactgct  tggcacggg  ccaggacca  caacttcgc  2640
ggcatcctg  cacagggtc  gcggatagc  ccacctgaa  cacctgtga  aggctacat  2700
tttgggaaa  gaatctact  tgctgatat  gtgtccaaa  gtgcgaact  ctgccacac  2760
tctcaggga  acccgattg  cttaatact  ttgggagaa  ttgcccttg  aaacatgta  2820
gaactcaag  atgcttctc  catcagcaa  ttacccaag  gcaagcaca  tgtcaaagg  2880
ttgggcaaa  ccgcccctg  cccttcggc  agcatcacc  tggatggtg  agaggttcc  2940
ctgggaaca  ggattccgt  tggtgttaa  gacacctgc  tgctgtata  cgagtacat  3000
gtctacgac  ttgctcagg  gaatctgaa  tacctactg  aactgaagt  caatttcaa  3060
acctccttg  ggtagagtg  aggcgggct  tgccagcac  cggggccta  gggataatg  3120
ccctagtg  3128



<210> 9152
<211> 1013
<212> PRT
<213> Rattus norvegicus
<308> P27008
<400> 9152

Ala Glu Ala Thr Glu Arg Leu Tyr Arg Val Glu Tyr Ala Lys Ser Gly 
  1               5                  10                  15
Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser Leu 
             20                  25                  30
Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val Pro 
         35                  40                  45
His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile Arg 
     50                  55                  60
Gln Pro Asp Thr Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp Asp 
 65                  70                  75                  80
Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Ala Gly Lys 
                 85                  90                  95
Gly Gln His Gly Gly Gly Gly Lys Ala Glu Lys Thr Leu Gly Asp Phe 
             100                105                110
Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys Met 
         115                120                125
Glu Lys Ile Glu Lys Gly Gln Met Arg Leu Ser Lys Lys Met Leu Asp 
     130                135                140
Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro Thr 
 145                150                155                160
Cys Phe Val Lys Asn Arg Asp Glu Leu Gly Phe Arg Pro Glu Tyr Ser 
                 165                170                175
Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ser Ala Glu Asp Lys Glu 
             180                185                190
Ala Leu Lys Lys Gln Leu Pro Ala Val Lys Ser Glu Gly Lys Arg Lys 
         195                200                205
Cys Asp Glu Val Asp Gly Ile Asp Glu Val Ala Lys Lys Lys Ser Lys 
     210                215                220
Lys Gly Lys Asp Lys Glu Ser Ser Lys Leu Glu Lys Ala Leu Lys Ala 
 225                230                235                240
Gln Asn Glu Leu Val Trp Asn Ile Lys Asp Glu Leu Lys Lys Ala Cys 
                 245                250                255
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Gln Gln Gln Val 
             260                265                270
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Ala 
         275                280                285
Phe Gly Ala Leu Leu Pro Cys Lys Glu Cys Ser Gly Gln Leu Val Phe 
     290                295                300
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys 
 305                310                315                320
Cys Met Val Lys Thr Gln Asn Pro Ser Arg Lys Glu Trp Val Thr Pro 
                 325                330                335
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Ile Lys Lys 
             340                345                350
Gln Asp Arg Leu Phe Pro Pro Glu Ser Ser Ala Pro Ala Pro Pro Ala 
         355                360                365
Pro Pro Val Ser Ile Thr Ser Ala Pro Thr Ala Val Asn Ser Ser Ala 
     370                375                380
Pro Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys 
 385                390                395                400
Leu Ser Gln Asn Lys Asp Glu Ala Lys Ala Met Ile Glu Lys Leu Gly 
                 405                410                415
Gly Lys Leu Thr Gly Ser Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr 
             420                425                430
Lys Lys Glu Val Glu Lys Met Ser Lys Lys Met Glu Glu Val Lys Ala 
         435                440                445
Ala Asn Val Arg Val Val Cys Glu Asp Phe Leu Gln Asp Val Ser Ala 
     450                455                460
Ser Ala Lys Ser Leu Gln Glu Leu Leu Ser Ala His Ser Leu Ser Ser 
 465                470                475                480
Trp Gly Ala Glu Val Lys Val Glu Pro Gly Glu Val Val Val Pro Lys 
                 485                490                495
Gly Lys Ser Ala Ala Pro Ser Lys Lys Ser Lys Gly Ala Val Lys Glu 
             500                505                510
Glu Gly Val Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys Gly 
         515                520                525
Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His Val 
     530                535                540
Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val Asp 
 545                550                555                560
Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu Ser 
                 565                570                575
Asp Lys Glu Ser Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val Gly 
             580                585                590
Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu Asp 
         595                600                605
Ala Val Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn Ala 
     610                615                620
Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro Leu 
 625                630                635                640
Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Ala Val 
                 645                650                655
Lys Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Glu Leu Val 
             660                665                670
Gly Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Leu Val Glu Tyr 
         675                680                685
Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Arg Arg Gln 
     690                695                700
Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val Ser 
 705                710                715                720
Gln Gly Ser Ser Glu Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe Tyr 
                 725                730                735
Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu Asn 
             740                745                750
Asn Thr Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu Leu 
         755                760                765
Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp Ser 
     770                775                780
Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp Ile 
 785                790                795                800
Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Val Ile Arg Lys Tyr 
                 805                810                815
Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu Val 
             820                825                830
Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Ser Gln Arg Tyr Lys 
         835                840                845
Pro Phe Arg Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser Arg 
     850                855                860
Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala Pro 
 865                870                875                880
Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr Phe 
                 885                890                895
Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln Gly 
             900                905                910
Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn Met 
         915                920                925
Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly Lys 
     930                935                940
His Ser Val Lys Gly Leu Gly Lys Thr Ala Pro Asp Pro Ser Ala Ser 
 945                950                955                960
Ile Thr Leu Asp Gly Val Glu Val Pro Leu Gly Thr Gly Ile Pro Ser 
                 965                970                975
Gly Val Asn Asp Thr Cys Leu Leu Tyr Asn Glu Tyr Ile Val Tyr Asp 
             980                985                990
Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn Phe 
         995                1000                1005
Lys Thr Ser Leu Trp 
     1010



<210> 9153
<211> 3640
<212> DNA
<213> Homo sapiens
<308> M18112
<400> 9153

aatctatca  gaacgcgtg  gtcgcgtgt  cgtgcggct  tggccgctc  gctcggctg  60
gtgagcgca  gcgagcgca  cggcagcgt  tttctaggt  gtgcgtcgg  cttccggag  120
tttgcggca  ctagggagg  tggcggagt  ttcggataa  ctctatcga  tcgagtacg  180
caagagcgg  cgcgcctct  gcaagaaat  cagcgagag  atccccaag  actcgctcc  240
gatggccat  atggtgcag  cgcccatgt  tgatggaaa  gtcccacac  ggtaccact  300
ctcctgctt  tggaaggtg  gccactcca  ccggcaccc  gacgttcag  tggatgggt  360
ctctgagct  cggtgggat  accagcaga  agtcaagaa  acagcggaa  ctggaggag  420
gacaggcaa  ggccaggat  gaattggta  caaggcaga  aagactctg  gtgactttg  480
agcagagta  gccaagtcc  acagaagta  gtgcaaggg  tgtatggag  agatagaaa  540
gggccaggt  cgcctgtcc  agaagatgg  ggacccgga  aagccacag  taggcatga  600
tgaccgctg  taccatcca  gctgctttg  caagaacag  gaggagctg  gtttccggc  660
cgagtacag  gcgagtcag  tcaagggct  cagcctcct  gctacagag  ataaagaag  720
cctgaagaa  cagctccca  gagtcaaga  tgaaggaaa  agaaaaggc  atgaggtgg  780
tggagtgga  gaagtggcg  agaagaaat  taaaaaaga  aaagacaag  atagtaagc  840
tgaaaaagc  ctaaaggct  agaacgacc  gatctggaa  atcaaggac  agctaaaga  900
agtgtgttc  actaatgac  tgaaggagc  actcatctt  aacaagcag  aagtgcctt  960
tggggagtc  gcgatcttg  accgagtag  tgatggcat  gtgttcggt  ccctccttc  1020
ctgcgagga  tgctcgggt  agctggtct  caagagcga  gcctattac  gcactgggg  1080
cgtcactgc  tggaccaag  gtatggtca  gacacagac  cccaaccgg  aggagtggg  1140
aaccccaaa  gaattccga  aaatctctt  cctcaagaa  ttgaaggtt  aaaagcagg  1200
ccgtatatt  cccccagaa  ccagcgcct  cgtggcggc  acgcctccg  cctccacag  1260
ctcggctcc  gctgctgtg  actcctctg  ttcagcaga  aagccatta  ccaacatga  1320
gatcctgac  ctcgggaag  tgtcccgga  caaggatga  gtgaaggcc  tgattgaga  1380
actcggggg  aagttgacg  ggacggcca  caaggcttc  ctgtgcatc  gcaccaaaa  1440
ggaggtgga  aagatgaat  agaagatgg  ggaagtaaa  gaagccaac  tccgagttg  1500
gtctgagga  ttcctccag  acgtctccg  ctccaccaa  agccttcag  agttgttct  1560
agcgcacat  ttgtcccct  ggggggcag  ggtgaaggc  gagcctgtt  aagttgtgg  1620
cccaagagg  aagtcaggg  ctgcgctct  caaaaaaag  aagggccag  tcaaggagg  1680
aggtatcaa  aaatctgaa  agagaatga  attaactct  aaaggagga  cagctgtgg  1740
tcctgattc  ggactggaa  actctgcgc  tgtcctgga  aaaggtggg  aggtcttca  1800
tgccaccct  ggcctggtg  acatcgtta  aggaaccaa  tcctactac  agctgcagc  1860
tctggagga  gacaaggaa  acaggtatt  gatattcag  tcctggggc  gtgtgggta  1920
ggtgatcgg  agcaacaaa  tggaacaga  gccgtccaa  gaggatgcc  ttgagcact  1980
catgaaatt  tatgaagaa  aaaccggga  cgcttggca  tccaaaaat  tcacgaagt  2040
tcccaaaaa  ttctacccc  tggagattg  ctatggcca  gatgaagag  cagtgaaga  2100
gctgacagt  aatcctggc  ccaagtcca  gctccccaa  ccagttcag  acctcatca  2160
gatgatctt  gatgtggaa  gtatgaaga  agccatggt  gagtatgag  tcgaccttc  2220
gaagatgcc  ttggggaag  tgagcaaaa  gcagatcca  gccgcatac  ccatcctca  2280
tgaggtcca  caggcggtg  ctcagggca  cagcgactc  cagatcctg  atctctcaa  2340
tcgctttta  accctgatc  cccacgact  tgggatgaa  aagcctccg  tcctgaaca  2400
tgcagacag  gtgcaggcc  aggtggaaa  gcttgacaa  ctgctggac  tcgaggtgg  2460
ctacagtct  ctcagggga  ggtctgatg  tagcagcaa  gatcccatc  atgtcaact  2520
tgagaagct  aaaactgac  ttaaggtgg  tgacagaga  tctgaagaa  ccgagatca  2580
caggaagta  gttaagaac  ctcatgcaa  cacacacaa  gcgtatgac  tggaagtca  2640
cgatatctt  aagatagag  gtgaaggcg  atgccagcg  tacaagccc  ttaagcagc  2700
tcataaccg  agattgctg  ggcacgggt  caggaccac  aactttgct  ggatcctgt  2760
ccagggtct  cggatagcc  cgcctgaag  gcccgtgac  ggctacatg  ttggtaaag  2820
gatctattt  gctgacatg  tctccaaga  tgccaacta  tgccatacg  ctcagggag  2880
cccaatagg  ttaatcctg  tgggagaag  tgcccttgg  aacatgtat  aactgaagc  2940
cgcttcaca  atcagcaag  tacccaagg  caagcacag  gtcaaaggt  tgggcaaaa  3000
tacccctga  ccttcagct  acattagtc  ggatggtgt  gacgttcct  ttgggaccg  3060
gatttcatc  ggtgtgaat  acacctctc  actatataa  gagtacatt  tctatgata  3120
tgctcaggt  aatctgaag  atctgctga  actgaaatt  aattttaag  cctccctgt  3180
gtaattggg  gaggtagcc  agtcacacc  ggtggctct  gtatgaatt  acccgaagc  3240
cttctgcac  aactcacct  gccgctaag  tgctgatgg  tagtacctg  actaaacca  3300
ctcagaaag  attttacag  aacgtgtta  aggttttct  taacttctc  agtcccttg  3360
tttgtgttg  gtctgtggg  aggggttgt  ttggggttg  ttttgtttt  tcttgccag  3420
tagataaaa  tgacataga  aaaaggctg  agagagatt  tgttgcata  actagtcct  3480
tggaaaaaa  caagcttcg  tagaatgtc  gccttactg  tttccccag  gaaggaaaa  3540
tacacttcc  ccctttttt  taagtgttc  tctttagtt  tgattttgg  aagatgtta  3600
gcatttatt  ttagttaaa  ataaaaact  atttcatact  3640



<210> 9154
<211> 1013
<212> PRT
<213> Homo sapiens
<308> P09874
<400> 9154

Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser Gly 
  1               5                  10                  15
Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser Leu 
             20                  25                  30
Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val Pro 
         35                  40                  45
His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile Arg 
     50                  55                  60
His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp Asp 
 65                  70                  75                  80
Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly Lys 
                 85                  90                  95
Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp Phe 
             100                105                110
Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys Met 
         115                120                125
Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val Asp 
     130                135                140
Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro Gly 
 145                150                155                160
Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr Ser 
                 165                170                175
Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys Glu 
             180                185                190
Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg Lys 
         195                200                205
Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser Lys 
     210                215                220
Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala Gln 
 225                230                235                240
Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys Ser 
                 245                250                255
Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val Pro 
             260                265                270
Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val Phe 
         275                280                285
Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe Lys 
     290                295                300
Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys Cys 
 305                310                315                320
Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro Lys 
                 325                330                335
Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys Gln 
             340                345                350
Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr Pro 
         355                360                365
Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala Ser 
     370                375                380
Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys Leu 
 385                390                395                400
Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly Gly 
                 405                410                415
Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr Lys 
             420                425                430
Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu Ala 
         435                440                445
Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala Ser 
     450                455                460
Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro Trp 
 465                470                475                480
Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg Gly 
                 485                490                495
Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys Glu 
             500                505                510
Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys Gly 
         515                520                525
Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His Val 
     530                535                540
Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val Asp 
 545                550                555                560
Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu Asp 
                 565                570                575
Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val Gly 
             580                585                590
Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu Asp 
         595                600                605
Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn Ala 
     610                615                620
Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro Leu 
 625                630                635                640
Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr Val 
                 645                650                655
Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu Ile 
             660                665                670
Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu Tyr 
         675                680                685
Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg Gln 
     690                695                700
Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val Ser 
 705                710                715                720
Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe Tyr 
                 725                730                735
Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu Asn 
             740                745                750
Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu Leu 
         755                760                765
Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp Ser 
     770                775                780
Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp Ile 
 785                790                795                800
Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys Tyr 
                 805                810                815
Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu Val 
             820                825                830
Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr Lys 
         835                840                845
Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser Arg 
     850                855                860
Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala Pro 
 865                870                875                880
Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr Phe 
                 885                890                895
Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln Gly 
             900                905                910
Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn Met 
         915                920                925
Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly Lys 
     930                935                940
His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala Asn 
 945                950                955                960
Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser Ser 
                 965                970                975
Gly Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr Asp 
             980                985                990
Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn Phe 
         995                1000                1005
Lys Thr Ser Leu Trp 
     1010



<210> 9155
<211> 3628
<212> DNA
<213> Rattus norvegicus
<308> U94904
<400> 9155

ccaaagcgt  caccactca  tccttagca  gtgttgcat  tctgataaa  accttggcc  60
acaatgtcc  acagatggc  ggatattca  gcatcgcag  tacggagaa  ggaatcttc  120
atcaaccat  tttcacaaa  agttgatat  cataaagag  aagtggcaa  aagagaaat  180
ggtattttg  ctaccaata  aaacacttc  aggacccat  agattattg  accagccag  240
cttgagcgg  cagtccgtt  tattcgaaa  cctattgac  acacaattt  agatgacat  300
ggacatggc  taaaggtga  tacccagaa  atgaagatg  gtggactgc  acgtacaac  360
cctccaact  agaagcccc  aagtccccc  atgtcaggg  aggggacac  tgggcggca  420
tccccctat  gaacactgg  gccagtgcg  cctccagtg  taccaaatg  ttacgtacc  480
agcccaacc  gtaatatgg  tccctcgca  cagagccct  tgaggacag  ttctgtgaa  540
caaagaaat  gaacttaca  cagtgggag  agtggagga  gccacccaa  tagtcggag  600
agcagtcgg  agaacagcg  aagtggtag  gtgggggtt  ccatcgctg  tcctactcc  660
tctcctcct  gcgtctttc  aggtcatcc  gttcagttc  acagcatga  taggcctgc  720
tctcgccat  cgccaccca  aataggggg  tcattgccc  atagacgcc  tccttccat  780
acttcacaa  caagccttc  gaatcagat  aatggaggt  ctttttata  ccagaatcc  840
gtttcagat  caccacctc  accacctcc  gtggatgag  cagtgttcg  tgagtcccc  900
cctccacca  ctcctccag  ggactcaga  gaggaggaa  cagctgtgg  tgagtacag  960
gatccttac  ccgaagagg  cccaccatg  gcaccaagg  cttacttgg  aaaggtcgt  1020
gcaatctat  attatacga  agacaagga  gatgagctg  cctttcagg  aggagccat  1080
atctatgtc  tcaagaaga  cgatgatgg  tggtatgag  gagttatga  tggagtgac  1140
gggctcttc  ctgggaatt  cgttgagtc  catcatgca  tattcggag  aaagcccag  1200
acagccgtg  ttcttgttc  tggctcagg  attcccaga  tagctagag  ccctgggaa  1260
tccctccca  gaaatatga  gaagcatac  aatgataaa  ttactcttt  tattactgt  1320
ttggtttat  ccctagtat  aaaacctga  agccaagtc  cgaacaagt  gaacttctt  1380
ggtcacttt  cattatgcc  atctagatt  aaaaatgcc  tttctcagt  acggaaagg  1440
actaccaac  tcgaacata  agctaaaat  tataggacc  agactaact  gagaaaaaa  1500
tctgggatc  tctcaggaa  actgtacac  cttggattt  tctgtcctg  agaatctga  1560
acattggat  ctcattgcc  ctgctttgg  gctaacctc  tggcctggt  gacaccctt  1620
ccctttact  tcagtatat  gagaggttg  ttccagtgt  taaatactt  atttaacta  1680
ttttggatt  cttaaaaag  ctgtttttc  tctttaaca  tgtaaatcc  gtgttctct  1740
agcactgga  tgctaggtg  gttaatccc  aactccctt  catcctgtc  tgtttgtag  1800
ttataagga  gacaaaatg  gagtctcca  acattccca  ggttgttac  agtttgatt  1860
taatgcact  ttgcatgag  ctgcattgc  gatagcagc  agtaaaacc  atgtgaaat  1920
tggtaggta  ttcaagtac  gaggtgagc  tgctggaca  aaaggttcc  aaggagctc  1980
aagccttga  gcactgttt  agagtagag  ctaggaaat  agaccagct  ttactgttc  2040
tttgatatt  aaacacccc  ccccacctc  tttaagaag  gactagttg  aagtctctg  2100
cagtcactg  actgggaat  aaaggctgc  actgtgctc  tggaccatt  tcaatggca  2160
tgttagctg  tgccatttt  cttctctca  cctatagaa  aatcaagta  cctcctgat  2220
tgaagtgat  agactttaa  gtagccact  ctcgtaata  tctgaacct  gtgagtcag  2280
gtaaagagt  tactggaaa  gactaatat  gataaaata  ttaccagtc  cactgatga  2340
aaccagtct  tatttgaaa  aattggcat  ccctcatct  ctgaaaaga  gaggaagca  2400
agctgttgt  attcagatg  aggccttgc  catctgtct  gcgagtcta  aagaacaag  2460
gttgtagat  cgagaagaa  ggcaggctg  aaggacgcg  taatactcc  ctcgtagat  2520
tgttatctg  gcctgaggc  tcagtctgt  gcaagtctc  tacccaaac  gtgtccttc  2580
caagaccct  tttgcttta  ggttgtagg  tttgtttgt  tcagacacg  tgctcttct  2640
cttctgctt  gcctctcaa  tattaggac  acaaggagg  ccctacacc  ggagcagga  2700
ttttggttt  aatacacgt  gcatgcaca  cagcagcta  tacactttt  gactttttc  2760
aaatgcttt  gatttttct  taatttgct  ctagtgcac  tttcacttc  tggtttttg  2820
taggtcatc  tgactgtct  caggatatg  ccctgaagc  ctctgaacc  ttagctcca  2880
tatggatat  agcaagagt  tatatgaac  tttaactct  agtgtattg  tacatggaa  2940
cttgtgaaa  tagctatac  aattattta  ttaagtagc  ttttgctga  caagcttag  3000
gattgataa  acattggaa  cccagccaa  agttagctt  ttgtagtca  agaaacaac  3060
ggtggtagg  actggaaca  agctcacct  ctgaacctc  gctgaatta  ggtttgcag  3120
aaacacgtg  gcaatcctt  gtgctgaag  tgtgcgctg  gggtgatcc  tgggacagg  3180
gaccccact  gatccatgg  acaggtgac  ccactcctt  tattattga  tactgatgt  3240
attttaaaa  caaaacaca  aatacggtc  gttggcctt  tttccaccc  ttttaaact  3300
tagcaattt  ttttgaaat  tatgaattg  caaggaagg  tactctgaa  aatgagcca  3360
gcctacagg  aattggagc  ttttaatgt  tgtaatatt  tatagattg  atgctatta  3420
tactgtgag  ttatttcct  ttttattgt  aattttccc  cttatttgc  cattaacaa  3480
aatatggtt  atattagga  ttttaaaca  atgttgaaa  tttctgacc  gattgcaag  3540
cagtttacc  agacacagg  actgagggc  ctggtcaat  ctgaaatgt  tgactctgt  3600
cacagtttc  ttacccttt  aaaaaaaa  3628



<210> 9156
<211> 543
<212> PRT
<213> Rattus norvegicus
<308> AAC53493
<400> 9156

Met Ser Tyr Arg Trp Leu Asp Ile Gln Ala Ser Gln Leu Arg Arg Met 
  1               5                  10                  15
Glu Ser Ser Ile Asn His Ile Ser Gln Thr Val Asp Ile His Lys Glu 
             20                  25                  30
Lys Val Ala Arg Arg Glu Ile Gly Ile Leu Thr Thr Asn Lys Asn Thr 
         35                  40                  45
Ser Arg Thr His Lys Ile Ile Ala Pro Ala Ser Leu Glu Arg Pro Val 
     50                  55                  60
Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Thr Ile Leu Asp Asp Ile Gly 
 65                  70                  75                  80
His Gly Val Lys Val Ser Thr Gln Asn Met Lys Met Gly Gly Leu Pro 
                 85                  90                  95
Arg Thr Thr Pro Pro Thr Gln Lys Pro Pro Ser Pro Pro Met Ser Gly 
             100                105                110
Lys Gly Thr Leu Gly Arg His Ser Pro Tyr Arg Thr Leu Glu Pro Val 
         115                120                125
Arg Pro Pro Val Val Pro Asn Asp Tyr Val Pro Ser Pro Thr Arg Asn 
     130                135                140
Met Ala Pro Ser Gln Gln Ser Pro Val Arg Thr Ala Ser Val Asn Gln 
 145                150                155                160
Arg Asn Arg Thr Tyr Ser Ser Gly Ser Ser Gly Gly Ser His Pro Ser 
                 165                170                175
Ser Arg Ser Ser Ser Arg Glu Asn Ser Gly Ser Gly Ser Val Gly Val 
             180                185                190
Pro Ile Ala Val Pro Thr Pro Ser Pro Pro Ser Val Phe Pro Gly His 
         195                200                205
Pro Val Gln Phe Tyr Ser Met Asn Arg Pro Ala Ser Arg His Thr Pro 
     210                215                220
Pro Thr Ile Gly Gly Ser Leu Pro Tyr Arg Arg Pro Pro Ser Ile Thr 
 225                230                235                240
Ser Gln Thr Ser Leu Gln Asn Gln Met Asn Gly Gly Pro Phe Tyr Asn 
                 245                250                255
Gln Asn Pro Val Ser Asp Thr Pro Pro Pro Pro Pro Pro Val Asp Glu 
             260                265                270
Pro Val Phe Asp Glu Ser Pro Pro Pro Pro Pro Pro Pro Glu Asp Ser 
         275                280                285
Glu Glu Glu Glu Ala Ala Val Val Glu Tyr Ser Asp Pro Tyr Ala Glu 
     290                295                300
Glu Asp Pro Pro Trp Ala Pro Arg Ser Tyr Leu Glu Lys Val Val Ala 
 305                310                315                320
Ile Tyr Asp Tyr Thr Lys Asp Lys Glu Asp Glu Leu Ser Phe Gln Glu 
                 325                330                335
Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp Gly Trp Tyr Glu 
             340                345                350
Gly Val Met Asn Gly Val Thr Gly Leu Phe Pro Gly Asn Tyr Val Glu 
         355                360                365
Ser His His Ala Leu Phe Gly Val Lys Pro Ser Thr Ala Val Leu Leu 
     370                375                380
Val His Gly Ser Gly Ile Pro Arg Leu Ala Arg Gly Pro Gly Asn Ser 
 385                390                395                400
Leu Pro Gly Asn Met Met Lys His Thr Asn Asp Lys Val Thr Leu Phe 
                 405                410                415
Ile Thr Val Leu Val Tyr Pro Leu Val Ser Lys Pro Glu Ser Gln Val 
             420                425                430
Ser Asn Lys Trp Asn Phe Leu Gly His Phe Ala Leu Cys Leu Ser Arg 
         435                440                445
Leu Lys Asn Ala Ile Ser Gln Ser Arg Lys Gly Thr Thr Asn Ile Glu 
     450                455                460
His Ile Ala Lys Ile Tyr Arg Thr Lys Thr Asn Leu Arg Lys Lys Ser 
 465                470                475                480
Gly Ile Phe Ser Gly Ile Leu Tyr Thr Leu Gly Phe Leu Cys Pro Ala 
                 485                490                495
Glu Ser Glu Thr Leu Asp Ala His Cys Leu Cys Phe Gly Ala Asn Leu 
             500                505                510
Met Ala Trp Trp Thr Pro Leu Pro Phe Thr Phe Ser Ile Trp Arg Gly 
         515                520                525
Trp Phe Gln Cys Leu Asn Thr Leu Phe Asn Tyr Phe Trp Ile Ala 
     530                535                540



<210> 9157
<211> 1542
<212> DNA
<213> Homo sapiens
<308> AF260261
<400> 9157

atggcggag  tgcagatgc  gctggaaga  gaaatcccg  ggggccgcc  ggccctttt  60
gacagctac  caaatctgg  acgggtggc  gattactgc  agaacaact  catacagtc  120
gcagataag  agagagccc  agaagaaac  aaagcctac  ccacccaat  cttagcaag  180
gttgcctat  tgataaaca  cttggccaa  aatgtcctg  agatgctgg  tatccaggc  240
tcccagcta  gaaggatgg  atcttcaat  aatcatatt  cacaaacag  tgatattca  300
aaagagaaa  ttgcaagaa  agaaattgg  attttgact  ccaataaaa  cacttcaag  360
acacataag  ttattgctc  agccaacct  gaacgacca  ttcgttata  tagaaaacc  420
attgactat  caattctag  tgatattgg  catggagta  agtggttgc  tagatttaa  480
gtgagtacc  agaacatga  gatgggtgg  ctgccgcgt  caacacctc  aactcagaa  540
ccccctagt  cccctatgt  agggaaagg  acacttggg  ggcactccc  ctatcgcac  600
ctggagcca  tgcgtcctc  agtggtacc  aatgattac  tacctagcc  aacccgtaa  660
atggctccc  cgcagcaga  ccctgtgag  acagcttct  tgaatcaaa  aaatcgaac  720
tacagcagc  gtgggagta  tggagggag  cacccaagt  gtcggagca  cagtcgaga  780
aacagtgga  gtggtagtg  gggggttcc  attgctgtt  ctactccat  tcctcccag  840
gtctttcca  cccctgctg  ctctgctgg  actcctccc  ttcctgcta  ttctgcatc  900
gcccctgct  ctcttgttc  tgctactgt  ccttcctcc  ctgccccaa  cgctgctgc  960
gggggtgcc  caaaccttg  tgatggctt  acttctcca  ctccccctg  tgtttcttc  1020
actccccct  caggtcatc  tgtacagtt  tacagcatg  ataggcctg  ctctcgcca  1080
actccccca  caatagggg  ttcgttgcc  tatagacgc  ctccttcca  tacttcaca  1140
acaagcctt  agaatcaga  gaatggagg  cctttttat  gccagaatc  agtttcaga  1200
acaccacct  caccgccac  tgtggaaga  ccagtcttt  atgagtctc  cccacctcc  1260
cctcctcca  aagattacg  agaggagga  gctgctgtg  ttgagtata  tgatcctta  1320
gctgaagag  acccaccgt  ggctccacg  tcttacttg  aaaaggttg  ggcaattta  1380
gactataca  aagacaagg  agatgagct  tcctttcag  aaggagcca  tatttatgt  1440
atcaagaag  atgacgatg  ttggtatga  ggagttatg  atggagtga  tgggctttt  1500
cctgggaat  acgttgagt  tatcatgca  tattctgag  aa  1542



<210> 9158
<211> 475
<212> PRT
<213> Homo sapiens
<308> NP_005750
<400> 9158

Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
  1               5                  10                  15
Arg Ala Leu Phe Asp Ser Tyr Thr Asn Leu Glu Arg Val Ala Asp Tyr 
             20                  25                  30
Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
         35                  40                  45
Glu Thr Lys Ala Tyr Thr Thr Gln Ser Leu Ala Ser Val Ala Tyr Leu 
     50                  55                  60
Ile Asn Thr Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
 65                  70                  75                  80
Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Thr 
                 85                  90                  95
Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
             100                105                110
Thr Thr Asn Lys Asn Thr Ser Arg Thr His Lys Ile Ile Ala Pro Ala 
         115                120                125
Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Thr 
     130                135                140
Ile Leu Asp Asp Ile Gly His Gly Val Lys Val Ser Thr Gln Asn Met 
 145                150                155                160
Lys Met Gly Gly Leu Pro Arg Thr Thr Pro Pro Thr Gln Lys Pro Pro 
                 165                170                175
Ser Pro Pro Met Ser Gly Lys Gly Thr Leu Gly Arg His Ser Pro Tyr 
             180                185                190
Arg Thr Leu Glu Pro Val Arg Pro Pro Val Val Pro Asn Asp Tyr Val 
         195                200                205
Pro Ser Pro Thr Arg Asn Met Ala Pro Ser Gln Gln Ser Pro Val Arg 
     210                215                220
Thr Ala Ser Val Asn Gln Arg Asn Arg Thr Tyr Ser Ser Ser Gly Ser 
 225                230                235                240
Ser Gly Gly Ser His Pro Ser Ser Arg Ser Ser Ser Arg Glu Asn Ser 
                 245                250                255
Gly Ser Gly Ser Val Gly Val Pro Ile Ala Val Pro Thr Pro Ser Pro 
             260                265                270
Pro Ser Val Phe Pro Gly His Pro Val Gln Phe Tyr Ser Met Asn Arg 
         275                280                285
Pro Ala Ser Arg His Thr Pro Pro Thr Ile Gly Gly Ser Leu Pro Tyr 
     290                295                300
Arg Arg Pro Pro Ser Ile Thr Ser Gln Thr Ser Leu Gln Asn Gln Met 
 305                310                315                320
Asn Gly Gly Pro Phe Tyr Ser Gln Asn Pro Val Ser Leu Ala Pro Pro 
                 325                330                335
Pro Pro Ser Ile Leu Gln Val Thr Pro Gln Leu Pro Leu Met Gly Phe 
             340                345                350
Val Ala Arg Val Gln Glu Asn Ile Ser Asp Thr Pro Pro Pro Pro Pro 
         355                360                365
Pro Val Glu Glu Pro Val Phe Asp Glu Ser Pro Pro Pro Pro Pro Pro 
     370                375                380
Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala Val Val Glu Tyr Ser Asp 
 385                390                395                400
Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala Pro Arg Ser Tyr Leu Glu 
                 405                410                415
Lys Val Val Ala Ile Tyr Asp Tyr Thr Lys Asp Lys Glu Asp Glu Leu 
             420                425                430
Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp 
         435                440                445
Gly Trp Tyr Glu Gly Val Met Asn Gly Val Thr Gly Leu Phe Pro Gly 
     450                455                460
Asn Tyr Val Glu Ser Ile Met His Tyr Ser Glu 
 465                470                475



<210> 9159
<211> 2516
<212> DNA
<213> Rattus norvegicus
<308> U95178
<400> 9159

cccgtcatg  ctaacgaag  agaaacaag  acaaccaat  gtcagcctg  ccaacaggc  60
gcaccgaaa  caccatcaa  gaaggaaaa  aagaaaggt  ctgaaaaga  agatgagta  120
ctgttggcc  ggttcaaag  tgatggtgt  aaatacaag  ccaagctaa  cggtattga  180
gatgtgcct  atgcgaggg  agacaaaat  agtcaggat  ctatgatga  actcaaggg  240
atggcagca  ctggtcgct  tcagggaca  cacaagcaa  ggatctggg  caacatttc  300
ctgtctggc  taaaaatta  tgatgagaa  accggggta  tagagcatg  acatccagt  360
aataagatt  ccttcattg  tcgtgatgt  acagacaat  gagcatttg  ttatgtgtg  420
ggaggagaa  gccagcatc  attttttgc  ataaaaaca  ggcaacagg  tgaaccatt  480
gtcgtcgat  ttaaagacc  ttttcaagt  atctataat  taaagaaaa  ggaagaaga  540
aagaaaaag  ttgaagaag  caacaaagc  gaagagaat  ggagtgagg  cctaatgac  600
cttgatgat  aagctaaca  actgaagct  ggtgttgac  agatggatt  gtttgggga  660
atgtctaca  ctcctgacc  aaataatcc  acatcttca  caaacgacc  gcttgcttc  720
gatatcttt  cctcagaac  tccaggcca  atgtccccc  caggacaac  tgcagtccc  780
caggcgaac  ttatggatc  cttcaaaac  agtgctcct  ccccaatgg  gtcggggcc  840
ctcgtaggt  taggtactg  cccagtaac  cccccccaa  caggacctt  gacacctgt  900
gtcttcact  cttctacaa  tgtggtccc  ggagccata  taagtggcc  gccttccgg  960
tttggtcag  cactcgtct  tggtacaac  ccagcagtg  aagtttgga  tcagccttc  1020
tcatttgca  ctgcagctt  ccctccacc  ccggcagtt  ggtgtccta  cacatctgt  1080
gcacccaac  cttggtcat  cacaagtcc  ctggggaat  cttttcaga  tagtaatat  1140
tttccacct  ccaccatat  cactcagtc  tttcctcag  ctatgatgt  ctctgttct  1200
gtcacacct  cccaaccac  tccccgaaa  ggcccacta  aggacactc  tagtgatgc  1260
ttcactggc  tagacccac  tggggataa  gaggtcaag  aagtgaaag  aatgtttaa  1320
gacttccag  tgcggcagc  acctcttgt  ccctcgagg  agggggaga  accttcctc  1380
gggacctca  gcgccttct  cagttactt  aacaataaa  ttggcattc  tcaggagca  1440
gtagaccat  atgattttg  tgccaatca  ctgttgaac  agattaatg  accaccaaa  1500
ccagccccc  gacaaggtg  cctctcggg  accaaatct  ctgacaatt  actcgagaa  1560
cctttctct  aagggttca  ctcaacaaa  ccctccgtg  tctctcagc  tgcatcttc  1620
gatgcccac  ggagccctt  tggaaatcc  tttgcctaa  ttctttctg  agttgtaat  1680
ctgactgac  atccagatg  gcaaaaggc  ggctttggt  aaggattaa  cagatagcc  1740
gaaacgtgc  gacctctgt  cttgctcca  ctttgatgt  ttacctgtt  ccctacttg  1800
ctttgcctc  tgtacttgt  aaaagcctt  cactctctc  aggctaaag  tacactgaa  1860
caatggctt  acataaatt  aactcctaa  ctctctagc  ccaatataa  tgaagtagc  1920
tccctacca  atccttgtc  gtcgtgctc  tagaacctt  cagaatatt  tccgtttta  1980
cctcaattt  ggaggtgtg  ccaccttta  ccttaatat  acactgcct  gagtaaatg  2040
ccaaatcct  gtagctctc  aggtcattt  tgattcctg  tgtgcatca  aaatctaaa  2100
attaatatt  acattaata  gaaagcaag  caccttgct  cccattccc  ctcagacaa  2160
tttttttat  ataaaatga  agcaagact  acttctcga  tccacccaa  gaccatttc  2220
agatggtct  tctcagcta  ttgcatcat  taccaatcc  actccaagt  gtgtttaca  2280
ttgacttga  aaggagaaa  gtctaactc  aaacataag  cattattca  agctaataa  2340
acaatttct  cctggggcc  cacattgtt  tcattccag  cactttgca  ctgtttgac  2400
ctgatgata  tatgcccta  attttcctt  aagattctg  ttttatttc  tgtgattct  2460
ttttctcaa  aaagatgat  attgtgtgc  tttactaaa  aaacaaaaa  aaaaaa  2516



<210> 9160
<211> 768
<212> PRT
<213> Rattus norvegicus
<308> O88797
<400> 9160

Met Ser Asn Glu Val Glu Thr Ser Thr Thr Asn Gly Gln Pro Asp Gln 
  1               5                  10                  15
Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Ser 
             20                  25                  30
Glu Lys Thr Asp Glu Tyr Leu Leu Ala Arg Phe Lys Gly Asp Gly Val 
         35                  40                  45
Lys Tyr Lys Ala Lys Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
     50                  55                  60
Gly Asp Lys Met Ser Gln Asp Ser Met Met Lys Leu Lys Gly Met Ala 
 65                  70                  75                  80
Ala Ala Gly Arg Ser Gln Gly Gln His Lys Gln Arg Ile Trp Val Asn 
                 85                  90                  95
Ile Ser Leu Ser Gly Ile Lys Ile Ile Asp Glu Lys Thr Gly Val Ile 
             100                105                110
Glu His Glu His Pro Val Asn Lys Ile Ser Phe Ile Ala Arg Asp Val 
         115                120                125
Thr Asp Asn Arg Ala Phe Gly Tyr Val Cys Gly Gly Glu Gly Gln His 
     130                135                140
Gln Phe Phe Ala Ile Lys Thr Gly Gln Gln Ala Glu Pro Leu Val Val 
 145                150                155                160
Asp Leu Lys Asp Leu Phe Gln Val Ile Tyr Asn Val Lys Lys Lys Glu 
                 165                170                175
Glu Glu Lys Lys Lys Val Glu Glu Ala Asn Lys Ala Glu Glu Asn Gly 
             180                185                190
Ser Glu Ala Leu Met Thr Leu Asp Asp Gln Ala Asn Lys Leu Lys Leu 
         195                200                205
Gly Val Asp Gln Met Asp Leu Phe Gly Asp Met Ser Thr Pro Pro Asp 
     210                215                220
Leu Asn Asn Pro Thr Glu Ser Arg Asp Ile Leu Leu Val Asp Leu Asn 
 225                230                235                240
Ser Glu Ile Asp Thr Asn Gln Asn Ser Leu Arg Glu Asn Pro Phe Leu 
                 245                250                255
Thr Asn Gly Val Thr Ser Cys Ser Leu Pro Arg Pro Lys Pro Gln Ala 
             260                265                270
Ser Phe Leu Pro Glu Ser Ala Phe Ser Ala Asn Leu Asn Phe Phe Pro 
         275                280                285
Thr Pro Asn Pro Asp Pro Phe Arg Asp Asp Pro Phe Ala Gln Pro Asp 
     290                295                300
Gln Ser Ala Pro Ser Ser Phe His Ser Leu Thr Ser Ala Asp Gln Lys 
 305                310                315                320
Lys Ala Asn Pro Gly Ser Leu Ser Thr Pro Gln Ser Lys Gly Pro Leu 
                 325                330                335
Asn Gly Asp Thr Asp Tyr Phe Gly Gln Gln Phe Asp Gln Ile Ser Asn 
             340                345                350
Arg Thr Gly Lys Gln Glu Ala Gln Gly Gly Pro Trp Pro Tyr Pro Ser 
         355                360                365
Ser Gln Thr Gln Gln Ala Val Arg Thr Gln Asn Gly Val Ser Glu Lys 
     370                375                380
Glu Gln Asn Gly Phe His Ile Lys Ser Ser Pro Asn Pro Phe Val Gly 
 385                390                395                400
Ser Pro Pro Lys Gly Leu Ser Val Pro Asn Gly Val Lys Gln Asp Leu 
                 405                410                415
Glu Ser Ser Val Gln Ser Ser Ala His Asp Ser Ile Ala Ile Ile Pro 
             420                425                430
Pro Pro Gln Ser Thr Lys Pro Gly Arg Gly Arg Arg Thr Ala Lys Ser 
         435                440                445
Ser Ala Asn Asp Leu Leu Ala Ser Asp Ile Phe Ala Ser Glu Pro Pro 
     450                455                460
Gly Gln Met Ser Pro Thr Gly Gln Pro Ala Val Pro Gln Ala Asn Phe 
 465                470                475                480
Met Asp Leu Phe Lys Thr Ser Ala Pro Ala Pro Met Gly Ser Gly Pro 
                 485                490                495
Leu Val Gly Leu Gly Thr Val Pro Val Thr Pro Pro Gln Ala Gly Pro 
             500                505                510
Trp Thr Pro Val Val Phe Thr Pro Ser Thr Thr Val Val Pro Gly Ala 
         515                520                525
Ile Ile Ser Gly Gln Pro Ser Gly Phe Gly Gln Pro Leu Val Phe Gly 
     530                535                540
Thr Thr Pro Ala Val Gln Val Trp Asn Gln Pro Ser Ser Phe Ala Thr 
 545                550                555                560
Ala Ala Ser Pro Pro Pro Pro Ala Val Trp Cys Pro Thr Thr Ser Val 
                 565                570                575
Ala Pro Asn Thr Trp Ser Ser Thr Ser Pro Leu Gly Asn Pro Phe Gln 
             580                585                590
Ser Ser Asn Ile Phe Pro Pro Ser Thr Ile Ser Thr Gln Ser Phe Pro 
         595                600                605
Gln Pro Met Met Ser Ser Val Leu Val Thr Pro Pro Gln Pro Pro Pro 
     610                615                620
Arg Asn Gly Pro Leu Lys Asp Thr Leu Ser Asp Ala Phe Thr Gly Leu 
 625                630                635                640
Asp Pro Leu Gly Asp Lys Glu Val Lys Glu Val Lys Glu Met Phe Lys 
                 645                650                655
Asp Phe Gln Leu Arg Gln Pro Pro Leu Val Pro Ser Arg Lys Gly Glu 
             660                665                670
Thr Pro Ser Ser Gly Thr Ser Ser Ala Phe Ser Ser Tyr Phe Asn Asn 
         675                680                685
Lys Val Gly Ile Pro Gln Glu His Val Asp His Asp Asp Phe Asp Ala 
     690                695                700
Asn Gln Leu Leu Asn Lys Ile Asn Glu Pro Pro Lys Pro Ala Pro Arg 
 705                710                715                720
Gln Gly Val Leu Ser Gly Thr Lys Ser Ala Asp Asn Ser Leu Glu Asn 
                 725                730                735
Pro Phe Ser Lys Gly Phe Ser Ser Thr Asn Pro Ser Val Val Ser Gln 
             740                745                750
Pro Ala Ser Ser Asp Ala His Arg Ser Pro Phe Gly Asn Pro Phe Ala 
         755                760                765



<210> 9161
<211> 2493
<212> DNA
<213> Homo sapiens
<308> AK024965
<400> 9161

ggagatggt  ccactgcac  ccagcctgg  cgacagaac  agactctgt  tcaaacaaa  60
aaacttaaa  ctgtactca  gactatgtt  aatattata  ataaatatg  tctatctga  120
aatttggct  ctatatgta  tgtctattc  tcccaatag  gcaatggat  catttttat  180
gttaggcac  tctaatctg  actccctgg  ttttatttt  tttctctct  tgagattca  240
attaattct  ggaaatata  aggacaacc  agtttaaat  cagtaactc  actcaaacc  300
tatattgat  tgaaaaggg  aggggaacg  agggcagaa  taatataca  gacttattc  360
tgccttatg  ctgtgaacc  taggcatac  tgtttgtgt  tttaactcc  tttcactat  420
aatatgaag  tcactgaat  tgtatcttt  tttttagat  gaggaagcc  gcaaagcag  480
tgaggtaaa  ttgcatctt  acttcttgt  aatcatgtg  gtgacatgc  taagcccct  540
ttttctacc  gcccaacca  tctcgccac  tcgcttatt  ctatgtgtt  atgacttct  600
tgatcatga  agatgttta  ttaaaagat  ataccaaaa  cattgctgc  tagcagact  660
atagagtgg  caaatacat  ttatagaca  agctcaact  aatccttaa  tatttgcta  720
cttttcaga  tgggagtga  gccctaatg  ttctagatg  ccaaactaa  aaactgaaa  780
cgggtgttg  ccagatgga  ttgtttggg  acatgtcta  acctcctga  ctaaatagt  840
caacagtaa  tgtttgttt  taaatttgc  atgtaataa  atgacatct  taactcaaa  900
tggcaataa  cagaaatct  aagcatctc  ttgaaactt  gaaggtgac  gttgatttt  960
gcaaatgaa  tgtcaatgg  ttttagaat  aatgtgaat  ttaagtcac  atgggaacc  1020
atccacact  attcagtta  attaatatt  cttacagat  aaacctgaa  aataagtca  1080
caatgtagt  cttcttggt  tcacttagg  ttagaagga  gaggtgaat  atagtcctt  1140
aataagcct  cttgaagaa  gtatgactg  tagatggtt  atcataaag  ctcctggcc  1200
cttcatttc  tttgcattc  gtctgttgc  atttagcag  ataaatttg  tgtgaagta  1260
gatttaaaa  aaacaagtg  ctcagttat  ttccaccaa  gcttgtcct  gttagaaag  1320
tgcccattc  cataggatt  tataccata  ccagtctgc  caatattga  tgatctgta  1380
caaccctgt  agaacagaa  agtattttc  tttataaat  aaaaaaaaa  ggtggttca  1440
ggaaaaaaa  agaagaaaa  aaaataaaa  ggaaagagg  ccagattca  gacttaggc  1500
caagtcttc  gaccttcca  aacatacct  taatgaaaa  gtccatgac  ttttgaatg  1560
cttcttgca  cttctttta  ttatgtaac  gtttcctga  cacctgcta  ttgcaaggc  1620
tagcagtaa  atgcacaac  tcaatgaca  catggaatt  actctccgg  agggagacc  1680
acattaaaa  taatcacat  gttagtaat  gatgttact  cagggtatt  atctagttc  1740
gattcaggt  atgcttctg  aggagtgag  ttctagatt  gaacataaa  gatgagaag  1800
caataaaca  acaaaaaga  aattagtct  gaataatgg  gggaaatgt  tagaaagga  1860
tctcttgta  cagaaaatt  tcatggaag  ctatgtgac  aaggttaca  gagttgaag  1920
aatggatca  agattggat  aaattctcc  ttcagactt  tgcagagaa  ttgaggcct  1980
tgaatcctt  ctgcataaa  ctttcaggt  aaatgagat  gagaggagc  gggacttca  2040
gcattcttc  ctgacccta  ccatatgag  atcacaatg  atggtagca  tctaaaatg  2100
ctttaagag  gaagcctgt  taatattca  tttagcagt  agccctaac  cacttgcct  2160
tagaacctt  cattcttca  aatttttgt  atagttctg  ggataaact  tttaaagta  2220
tagactaga  tatcctgac  ggtccatcc  aactctgag  tccttttgg  ttgtagtca  2280
ctttgtgct  tcctccatt  gtgatgttt  ctcaaataa  tcagtatct  aacacttac  2340
tcccaagta  aaatgacat  caaacaagt  atattcaaa  agagcaaag  actcaagat  2400
tgaagtgga  ttccactgg  ataggcaag  aagtactgc  tatataatc  acttctgta  2460
acttctaga  tgttctaaa  aaaaaaaaa  aaa  2493



<210> 9162
<211> 770
<212> PRT
<213> Homo sapiens
<308> NP_001334
<400> 9162

Met Ser Asn Glu Val Glu Thr Ser Ala Thr Asn Gly Gln Pro Asp Gln 
  1               5                  10                  15
Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Pro 
             20                  25                  30
Glu Lys Thr Asp Glu Tyr Leu Leu Ala Arg Phe Lys Gly Asp Gly Val 
         35                  40                  45
Lys Tyr Lys Ala Lys Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
     50                  55                  60
Gly Asp Lys Met Ser Gln Asp Ser Met Met Lys Leu Lys Gly Met Ala 
 65                  70                  75                  80
Ala Arg Gly Arg Ser Gln Gly Gln His Lys Gln Arg Ile Trp Val Asn 
                 85                  90                  95
Ile Ser Leu Ser Gly Ile Lys Ile Ile Asp Glu Lys Thr Gly Val Ile 
             100                105                110
Glu His Glu His Pro Val Asn Lys Ile Ser Phe Ile Ala Arg Asp Val 
         115                120                125
Thr Asp Asn Arg Ala Phe Gly Tyr Val Cys Gly Gly Glu Gly Gln His 
     130                135                140
Gln Phe Phe Thr Ile Lys Thr Gly Gln Gln Ala Glu Pro Leu Val Val 
 145                150                155                160
Asp Leu Lys Asp Leu Phe Gln Val Ile Tyr Asn Val Lys Lys Lys Glu 
                 165                170                175
Glu Glu Lys Lys Lys Ile Glu Glu Ala Ser Lys Ala Val Glu Asn Gly 
             180                185                190
Ser Glu Ala Leu Arg Ile Leu Asp Asp Gln Thr Asn Lys Leu Lys Ser 
         195                200                205
Gly Val Asp Gln Met Asp Leu Phe Gly Asp Met Ser Thr Pro Pro Asp 
     210                215                220
Leu Asn Ser Pro Thr Glu Ser Lys Asp Ile Leu Leu Val Asp Leu Asn 
 225                230                235                240
Ser Glu Ile Asp Thr Asn Gln Asn Ser Leu Arg Glu Asn Pro Phe Leu 
                 245                250                255
Thr Asn Gly Ile Thr Ser Cys Ser Leu Pro Arg Pro Thr Pro Gln Ala 
             260                265                270
Ser Phe Leu Pro Glu Asn Ala Phe Ser Ala Asn Leu Asn Phe Phe Pro 
         275                280                285
Thr Pro Asn Pro Asp Pro Phe Arg Asp Asp Pro Phe Thr Gln Pro Asp 
     290                295                300
Gln Ser Thr Pro Ser Ser Phe Asp Ser Leu Lys Ser Pro Asp Gln Lys 
 305                310                315                320
Lys Glu Asn Ser Ser Ser Ser Ser Thr Pro Leu Ser Asn Gly Pro Leu 
                 325                330                335
Asn Gly Asp Val Asp Tyr Phe Gly Gln Gln Phe Asp Gln Ile Ser Asn 
             340                345                350
Arg Thr Gly Lys Gln Glu Ala Gln Ala Gly Pro Trp Pro Phe Ser Ser 
         355                360                365
Ser Gln Thr Gln Pro Ala Val Arg Thr Gln Asn Gly Val Ser Glu Arg 
     370                375                380
Glu Gln Asn Gly Phe Ser Val Lys Ser Ser Pro Asn Pro Phe Val Gly 
 385                390                395                400
Ser Pro Pro Lys Gly Leu Ser Ile Gln Asn Gly Val Lys Gln Asp Leu 
                 405                410                415
Glu Ser Ser Val Gln Ser Ser Pro His Asp Ser Ile Ala Ile Ile Pro 
             420                425                430
Pro Pro Gln Ser Thr Lys Pro Gly Arg Gly Arg Arg Thr Ala Lys Ser 
         435                440                445
Ser Ala Asn Asp Leu Leu Ala Ser Asp Ile Phe Ala Pro Pro Val Ser 
     450                455                460
Glu Pro Ser Gly Gln Ala Ser Pro Thr Gly Gln Pro Thr Ala Leu Gln 
 465                470                475                480
Pro Asn Pro Leu Asp Leu Phe Lys Thr Ser Ala Pro Ala Pro Val Gly 
                 485                490                495
Pro Leu Val Gly Leu Gly Gly Val Thr Val Thr Leu Pro Gln Ala Gly 
             500                505                510
Pro Trp Asn Thr Ala Ser Leu Val Phe Asn Gln Ser Pro Ser Met Ala 
         515                520                525
Pro Gly Ala Met Met Gly Gly Gln Pro Ser Gly Phe Ser Gln Pro Val 
     530                535                540
Ile Phe Gly Thr Ser Pro Ala Val Ser Gly Trp Asn Gln Pro Ser Pro 
 545                550                555                560
Phe Ala Ala Ser Thr Pro Pro Pro Val Pro Val Val Trp Gly Pro Ser 
                 565                570                575
Ala Ser Val Ala Pro Asn Ala Trp Ser Thr Thr Ser Pro Leu Gly Asn 
             580                585                590
Pro Phe Gln Ser Asn Ile Phe Pro Ala Pro Ala Val Ser Thr Gln Pro 
         595                600                605
Pro Ser Met His Ser Ser Leu Leu Val Thr Pro Pro Gln Pro Pro Pro 
     610                615                620
Arg Ala Gly Pro Pro Lys Asp Ile Ser Ser Asp Ala Phe Thr Ala Leu 
 625                630                635                640
Asp Pro Leu Gly Asp Lys Glu Ile Lys Asp Val Lys Glu Met Phe Lys 
                 645                650                655
Asp Phe Gln Leu Arg Gln Pro Pro Ala Val Pro Ala Arg Lys Gly Glu 
             660                665                670
Gln Thr Ser Ser Gly Thr Leu Ser Ala Phe Ala Ser Tyr Phe Asn Ser 
         675                680                685
Lys Val Gly Ile Pro Gln Glu Asn Ala Asp His Asp Asp Phe Asp Ala 
     690                695                700
Asn Gln Leu Leu Asn Lys Ile Asn Glu Pro Pro Lys Pro Ala Pro Arg 
 705                710                715                720
Gln Val Ser Leu Pro Val Thr Lys Ser Thr Asp Asn Ala Phe Glu Asn 
                 725                730                735
Pro Phe Phe Lys Asp Ser Phe Gly Ser Ser Gln Ala Ser Val Ala Ser 
             740                745                750
Ser Gln Pro Val Ser Ser Glu Met Tyr Arg Asp Pro Phe Gly Asn Pro 
         755                760                765
Phe Ala 
     770



<210> 9163
<211> 1518
<212> DNA
<213> Rattus norvegicus
<308> U95727
<400> 9163

gtcgcgctc  ttccgctcc  ccgcctgct  gcgagtgct  ccgggcagg  cgccatggc  60
aacgtggcc  acacgaagc  gtacgacat  ctgggcgtc  ctcccggcg  cagcgagaa  120
gagctgaag  aggcatacc  aaagttagc  aaagaatac  atcctgata  gaatccaaa  180
gctggagat  aatttaaag  aataagttt  gcctatgaa  tattgtcaa  tccagagaa  240
cgggagcta  atgacagat  tggagaaca  ggtctacgg  aaggcagcg  cgggggtgg  300
ggcatggat  atattttct  acatatttt  ggtggagga  tgtttggct  catgggcaa  360
caaagtaga  gtcgaaatg  cagaagaag  ggcgaggac  tgatgcatc  gctgaaagt  420
tctttagaa  acctgtaca  tggcaagac  accaagctg  agctcagca  gaatgtgct  480
tgtagcgcg  gcagtggcc  aggtggaaa  tctggagct  ttcagaaat  cagtgcttg  540
cggggtcga  gtgtgcgca  tatgataag  cagctggct  cagggatgg  acagcagat  600
cagtctgtg  gctctgact  taatggaga  ggagaggtc  tcaatgaaa  agaccgctg  660
aaaaaatgt  aaggaaaga  ggtgattaa  gaagtcaag  ttctggaag  tcatgtaga  720
aaaggcatg  aacatggac  gagaattac  ttcactggg  aagcagacc  ggctccagg  780
gtggaacct  gagatattg  tcttttcgt  caggaaaaa  aacatgagg  gttccagag  840
gatgggaat  atctgcata  gacatataa  ataggactt  ttgaagctt  gtgtggatt  900
cagttcaca  ttaaacatc  tgatgctcg  cagattgta  tgaaatacc  ccctggcaa  960
gtaattgaa  caggatgtg  tcgtgttgt  cgaggcgaa  gaatgccac  gtatcgtaa  1020
ccctttgaa  agggtgatc  ttacataaa  tttgatgtg  agtttcctg  aaacaactg  1080
atcaaccca  acaaacttt  tgaattaga  gatctcctg  catctagac  agaagttcc  1140
aatgtaatt  gggagacag  agaagtaga  cttcaggaa  tcgatagca  tcgaggctc  1200
ggaggtggt  agaggcgtg  agcctacaa  gacagctct  atgaggaaa  cagcagcca  1260
catggacct  gagtgcagt  tgcccatca  taaactgca  gcaactgca  ggtggattt  1320
ctccacatt  gccggattt  ccagctgct  gagtacctg  atgagtcca  atgaactga  1380
ggacatctg  tgatctatg  gtaacttct  aacttggta  agtatcaca  agtgtataa  1440
ttaaactaa  cacggagct  tacgtcttc  tttcgactg  ctatagcag  gtaaagcac  1500
tgaaataag  ctcccttt  1518



<210> 9164
<211> 412
<212> PRT
<213> Rattus norvegicus
<308> O35824
<400> 9164

Met Ala Asn Val Ala Asp Thr Lys Leu Tyr Asp Ile Leu Gly Val Pro 
  1               5                  10                  15
Pro Gly Ala Ser Glu Asn Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala 
             20                  25                  30
Lys Glu Tyr His Pro Asp Lys Asn Pro Asn Ala Gly Asp Lys Phe Lys 
         35                  40                  45
Glu Ile Ser Phe Ala Tyr Glu Val Leu Ser Asn Pro Glu Lys Arg Glu 
     50                  55                  60
Leu Tyr Asp Arg Tyr Gly Glu Gln Gly Leu Arg Glu Gly Ser Gly Gly 
 65                  70                  75                  80
Gly Gly Gly Met Asp Asp Ile Phe Ser His Ile Phe Gly Gly Gly Leu 
                 85                  90                  95
Phe Gly Phe Met Gly Asn Gln Ser Arg Ser Arg Asn Gly Arg Arg Arg 
             100                105                110
Gly Glu Asp Met Met His Pro Leu Lys Val Ser Leu Glu Asp Leu Tyr 
         115                120                125
Asn Gly Lys Thr Thr Lys Leu Gln Leu Ser Lys Asn Val Leu Cys Ser 
     130                135                140
Ala Cys Ser Gly Gln Gly Gly Lys Ser Gly Ala Val Gln Lys Cys Ser 
 145                150                155                160
Ala Cys Arg Gly Arg Gly Val Arg Ile Met Ile Arg Gln Leu Ala Pro 
                 165                170                175
Gly Met Val Gln Gln Met Gln Ser Val Cys Ser Asp Cys Asn Gly Glu 
             180                185                190
Gly Glu Val Ile Asn Glu Lys Asp Arg Cys Lys Lys Cys Glu Gly Lys 
         195                200                205
Lys Val Ile Lys Glu Val Lys Ile Leu Glu Val His Val Asp Lys Gly 
     210                215                220
Met Lys His Gly Gln Arg Ile Thr Phe Thr Gly Glu Ala Asp Gln Ala 
 225                230                235                240
Pro Gly Val Glu Pro Gly Asp Ile Val Leu Phe Val Gln Glu Lys Glu 
                 245                250                255
His Glu Val Phe Gln Arg Asp Gly Asn Asp Leu His Met Thr Tyr Lys 
             260                265                270
Ile Gly Leu Val Glu Ala Leu Cys Gly Phe Gln Phe Thr Phe Lys His 
         275                280                285
Leu Asp Ala Arg Gln Ile Val Val Lys Tyr Pro Pro Gly Lys Val Ile 
     290                295                300
Glu Pro Gly Cys Val Arg Val Val Arg Gly Glu Gly Met Pro Gln Tyr 
 305                310                315                320
Arg Asn Pro Phe Glu Lys Gly Asp Leu Tyr Ile Lys Phe Asp Val Gln 
                 325                330                335
Phe Pro Glu Asn Asn Trp Ile Asn Pro Asp Lys Leu Ser Glu Leu Glu 
             340                345                350
Asp Leu Leu Pro Ser Arg Pro Glu Val Pro Asn Val Ile Gly Glu Thr 
         355                360                365
Glu Glu Val Glu Leu Gln Glu Phe Asp Ser Thr Arg Gly Ser Gly Gly 
     370                375                380
Gly Gln Arg Arg Glu Ala Tyr Asn Asp Ser Ser Asp Glu Glu Ser Ser 
 385                390                395                400
Ser His His Gly Pro Gly Val Gln Cys Ala His Gln 
                 405                410



<210> 9165
<211> 1993
<212> DNA
<213> Homo sapiens
<308> NM_005880
<400> 9165

ccgctctgt  tgcttcgcc  ccttctccc  gagcactgc  cggccggcc  ccatggcta  60
cgtggctga  acgaagctg  acgacatcc  gggcgtccc  cccggcgcc  gcgagaacg  120
gctgaagaa  gcatacaga  agttagcca  ggaatatca  cctgataag  atccaaatg  180
aggagacaa  tttaaagaa  taagttttg  atatgaagt  ctatcaaat  ctgagaagc  240
tgagttata  gacagatac  gagagcaag  tcttcggga  ggcagcggc  gaggtggtg  300
catggatga  attttctct  acatttttg  tgggggatt  ttcggcttc  tgggcaatc  360
gagtagaag  cgaaatggc  gaagaagag  agaggacat  atgcatcca  tcaaagtat  420
tttagaaga  ctgtataat  gcaagacaa  caaactaca  cttagcaag  atgtgctct  480
tagtgcatg  agtggccaa  gcggaaagt  tggagctgt  caaaagtgt  gtgcttgtc  540
aggtcgagg  gtgcgcatc  tgatcagac  gctggctcc  gggatggta  aacagatgc  600
gtctgtgtg  tctgattgt  atggagaag  agaggtaat  aatgaaaaa  accgctgta  660
aaaatgtga  gggaagaag  tgattaaag  agtcaagat  cttgaagtc  acgtagaca  720
aggcatgaa  catggacag  gaattacat  cactgggga  gcagaccag  ccccaggag  780
ggaacccgg  gacattgtt  ttttgctac  ggagaaaga  catgaggta  ttcagagag  840
tgggaatga  ttgcacatg  catataaaa  aggacttgt  gaagctcta  gtggatttc  900
gttcacatt  aagcacctt  atggacgtc  gattgtggt  aaatacccc  ctggcaaag  960
aattgaacc  gggtgtgtt  gtgtagttc  aggtgaagg  atgccgcag  atcgtaatc  1020
ctttgaaaa  ggtgatctt  acataaagt  tgatgtgca  tttcctgaa  acaactgga  1080
caacccaga  aagctttct  aactagaag  tcttctgcc  tctagaccg  aagttccta  1140
cataattgg  gaaacagag  aggtagagc  tcaggaatt  gatagcact  gaggctcag  1200
aggtggtca  aggcgtgaa  cctataatg  tagctctga  gaagaaagc  gcagccatc  1260
tggacctgg  gtgcagtgt  cccatcagt  aactctgca  acaaattgc  caggtggat  1320
ttctttcca  atttgcctg  tttgttctc  gcaatccag  tggagtgtc  tatcaatcc  1380
agatgaact  agggacatc  gttggtcta  gtataactt  taaaattgg  atagtatct  1440
cagagtgta  aatttaaac  aaccacaaa  ctttacatc  tcattttga  tgttccata  1500
caaaataaa  cacttgaaa  gaaacaaaa  tccctttca  acatggatt  ttataagtt  1560
caatcctgg  atctgtgct  gatttttat  agttttgtg  aaattttta  gtttcatat  1620
ttaaattta  atcccacat  gtaaagttt  tacaatttg  cctgaagct  tgtgtttgg  1680
tgcacctgc  taagctgct  caaataaaa  aaaaaattt  atagcctgt  tctatcatt  1740
aaatgcatg  aaaaaaatg  gctttgcac  caatgggtt  ggagctgac  gggaacaat  1800
gaaaaaatt  cattagctg  ggttgtaaa  tttttttgt  tttgggttt  gtttttttt  1860
tgttttttt  ttttttttt  ttaccattt  gtgaaaggt  tttgaaaat  gataataaa  1920
agcggttgg  gtaaattta  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1980
aaaaaaaaa  aaa  1993



<210> 9166
<211> 412
<212> PRT
<213> Homo sapiens
<308> O60884
<400> 9166

Met Ala Asn Val Ala Asp Thr Lys Leu Tyr Asp Ile Leu Gly Val Pro 
  1               5                  10                  15
Pro Gly Ala Ser Glu Asn Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala 
             20                  25                  30
Lys Glu Tyr His Pro Asp Lys Asn Pro Asn Ala Gly Asp Lys Phe Lys 
         35                  40                  45
Glu Ile Ser Phe Ala Tyr Glu Val Leu Ser Asn Pro Glu Lys Arg Glu 
     50                  55                  60
Leu Tyr Asp Arg Tyr Gly Glu Gln Gly Leu Arg Glu Gly Ser Gly Gly 
 65                  70                  75                  80
Gly Gly Gly Met Asp Asp Ile Phe Ser His Ile Phe Gly Gly Gly Leu 
                 85                  90                  95
Phe Gly Phe Met Gly Asn Gln Ser Arg Ser Arg Asn Gly Arg Arg Arg 
             100                105                110
Gly Glu Asp Met Met His Pro Leu Lys Val Ser Leu Glu Asp Leu Tyr 
         115                120                125
Asn Gly Lys Thr Thr Lys Leu Gln Leu Ser Lys Asn Val Leu Cys Ser 
     130                135                140
Ala Cys Ser Gly Gln Gly Gly Lys Ser Gly Ala Val Gln Lys Cys Ser 
 145                150                155                160
Ala Cys Arg Gly Arg Gly Val Arg Ile Met Ile Arg Gln Leu Ala Pro 
                 165                170                175
Gly Met Val Gln Gln Met Gln Ser Val Cys Ser Asp Cys Asn Gly Glu 
             180                185                190
Gly Glu Val Ile Asn Glu Lys Asp Arg Cys Lys Lys Cys Glu Gly Lys 
         195                200                205
Lys Val Ile Lys Glu Val Lys Ile Leu Glu Val His Val Asp Lys Gly 
     210                215                220
Met Lys His Gly Gln Arg Ile Thr Phe Thr Gly Glu Ala Asp Gln Ala 
 225                230                235                240
Pro Gly Val Glu Pro Gly Asp Ile Val Leu Leu Leu Gln Glu Lys Glu 
                 245                250                255
His Glu Val Phe Gln Arg Asp Gly Asn Asp Leu His Met Thr Tyr Lys 
             260                265                270
Ile Gly Leu Val Glu Ala Leu Cys Gly Phe Gln Phe Thr Phe Lys His 
         275                280                285
Leu Asp Gly Arg Gln Ile Val Val Lys Tyr Pro Pro Gly Lys Val Ile 
     290                295                300
Glu Pro Gly Cys Val Arg Val Val Arg Gly Glu Gly Met Pro Gln Tyr 
 305                310                315                320
Arg Asn Pro Phe Glu Lys Gly Asp Leu Tyr Ile Lys Phe Asp Val Gln 
                 325                330                335
Phe Pro Glu Asn Asn Trp Ile Asn Pro Asp Lys Leu Ser Glu Leu Glu 
             340                345                350
Asp Leu Leu Pro Ser Arg Pro Glu Val Pro Asn Ile Ile Gly Glu Thr 
         355                360                365
Glu Glu Val Glu Leu Gln Glu Phe Asp Ser Thr Arg Gly Ser Gly Gly 
     370                375                380
Gly Gln Arg Arg Glu Ala Tyr Asn Asp Ser Ser Asp Glu Glu Ser Ser 
 385                390                395                400
Ser His His Gly Pro Gly Val Gln Cys Ala His Gln 
                 405                410



<210> 9167
<211> 1518
<212> DNA
<213> Rattus norvegicus
<308> U95727
<400> 9167

gtcgcgctc  ttccgctcc  ccgcctgct  gcgagtgct  ccgggcagg  cgccatggc  60
aacgtggcc  acacgaagc  gtacgacat  ctgggcgtc  ctcccggcg  cagcgagaa  120
gagctgaag  aggcatacc  aaagttagc  aaagaatac  atcctgata  gaatccaaa  180
gctggagat  aatttaaag  aataagttt  gcctatgaa  tattgtcaa  tccagagaa  240
cgggagcta  atgacagat  tggagaaca  ggtctacgg  aaggcagcg  cgggggtgg  300
ggcatggat  atattttct  acatatttt  ggtggagga  tgtttggct  catgggcaa  360
caaagtaga  gtcgaaatg  cagaagaag  ggcgaggac  tgatgcatc  gctgaaagt  420
tctttagaa  acctgtaca  tggcaagac  accaagctg  agctcagca  gaatgtgct  480
tgtagcgcg  gcagtggcc  aggtggaaa  tctggagct  ttcagaaat  cagtgcttg  540
cggggtcga  gtgtgcgca  tatgataag  cagctggct  cagggatgg  acagcagat  600
cagtctgtg  gctctgact  taatggaga  ggagaggtc  tcaatgaaa  agaccgctg  660
aaaaaatgt  aaggaaaga  ggtgattaa  gaagtcaag  ttctggaag  tcatgtaga  720
aaaggcatg  aacatggac  gagaattac  ttcactggg  aagcagacc  ggctccagg  780
gtggaacct  gagatattg  tcttttcgt  caggaaaaa  aacatgagg  gttccagag  840
gatgggaat  atctgcata  gacatataa  ataggactt  ttgaagctt  gtgtggatt  900
cagttcaca  ttaaacatc  tgatgctcg  cagattgta  tgaaatacc  ccctggcaa  960
gtaattgaa  caggatgtg  tcgtgttgt  cgaggcgaa  gaatgccac  gtatcgtaa  1020
ccctttgaa  agggtgatc  ttacataaa  tttgatgtg  agtttcctg  aaacaactg  1080
atcaaccca  acaaacttt  tgaattaga  gatctcctg  catctagac  agaagttcc  1140
aatgtaatt  gggagacag  agaagtaga  cttcaggaa  tcgatagca  tcgaggctc  1200
ggaggtggt  agaggcgtg  agcctacaa  gacagctct  atgaggaaa  cagcagcca  1260
catggacct  gagtgcagt  tgcccatca  taaactgca  gcaactgca  ggtggattt  1320
ctccacatt  gccggattt  ccagctgct  gagtacctg  atgagtcca  atgaactga  1380
ggacatctg  tgatctatg  gtaacttct  aacttggta  agtatcaca  agtgtataa  1440
ttaaactaa  cacggagct  tacgtcttc  tttcgactg  ctatagcag  gtaaagcac  1500
tgaaataag  ctcccttt  1518



<210> 9168
<211> 412
<212> PRT
<213> Rattus norvegicus
<308> O35824
<400> 9168

Met Ala Asn Val Ala Asp Thr Lys Leu Tyr Asp Ile Leu Gly Val Pro 
  1               5                  10                  15
Pro Gly Ala Ser Glu Asn Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala 
             20                  25                  30
Lys Glu Tyr His Pro Asp Lys Asn Pro Asn Ala Gly Asp Lys Phe Lys 
         35                  40                  45
Glu Ile Ser Phe Ala Tyr Glu Val Leu Ser Asn Pro Glu Lys Arg Glu 
     50                  55                  60
Leu Tyr Asp Arg Tyr Gly Glu Gln Gly Leu Arg Glu Gly Ser Gly Gly 
 65                  70                  75                  80
Gly Gly Gly Met Asp Asp Ile Phe Ser His Ile Phe Gly Gly Gly Leu 
                 85                  90                  95
Phe Gly Phe Met Gly Asn Gln Ser Arg Ser Arg Asn Gly Arg Arg Arg 
             100                105                110
Gly Glu Asp Met Met His Pro Leu Lys Val Ser Leu Glu Asp Leu Tyr 
         115                120                125
Asn Gly Lys Thr Thr Lys Leu Gln Leu Ser Lys Asn Val Leu Cys Ser 
     130                135                140
Ala Cys Ser Gly Gln Gly Gly Lys Ser Gly Ala Val Gln Lys Cys Ser 
 145                150                155                160
Ala Cys Arg Gly Arg Gly Val Arg Ile Met Ile Arg Gln Leu Ala Pro 
                 165                170                175
Gly Met Val Gln Gln Met Gln Ser Val Cys Ser Asp Cys Asn Gly Glu 
             180                185                190
Gly Glu Val Ile Asn Glu Lys Asp Arg Cys Lys Lys Cys Glu Gly Lys 
         195                200                205
Lys Val Ile Lys Glu Val Lys Ile Leu Glu Val His Val Asp Lys Gly 
     210                215                220
Met Lys His Gly Gln Arg Ile Thr Phe Thr Gly Glu Ala Asp Gln Ala 
 225                230                235                240
Pro Gly Val Glu Pro Gly Asp Ile Val Leu Phe Val Gln Glu Lys Glu 
                 245                250                255
His Glu Val Phe Gln Arg Asp Gly Asn Asp Leu His Met Thr Tyr Lys 
             260                265                270
Ile Gly Leu Val Glu Ala Leu Cys Gly Phe Gln Phe Thr Phe Lys His 
         275                280                285
Leu Asp Ala Arg Gln Ile Val Val Lys Tyr Pro Pro Gly Lys Val Ile 
     290                295                300
Glu Pro Gly Cys Val Arg Val Val Arg Gly Glu Gly Met Pro Gln Tyr 
 305                310                315                320
Arg Asn Pro Phe Glu Lys Gly Asp Leu Tyr Ile Lys Phe Asp Val Gln 
                 325                330                335
Phe Pro Glu Asn Asn Trp Ile Asn Pro Asp Lys Leu Ser Glu Leu Glu 
             340                345                350
Asp Leu Leu Pro Ser Arg Pro Glu Val Pro Asn Val Ile Gly Glu Thr 
         355                360                365
Glu Glu Val Glu Leu Gln Glu Phe Asp Ser Thr Arg Gly Ser Gly Gly 
     370                375                380
Gly Gln Arg Arg Glu Ala Tyr Asn Asp Ser Ser Asp Glu Glu Ser Ser 
 385                390                395                400
Ser His His Gly Pro Gly Val Gln Cys Ala His Gln 
                 405                410



<210> 9169
<211> 1993
<212> DNA
<213> Homo sapiens
<308> NM_005880
<400> 9169

ccgctctgt  tgcttcgcc  ccttctccc  gagcactgc  cggccggcc  ccatggcta  60
cgtggctga  acgaagctg  acgacatcc  gggcgtccc  cccggcgcc  gcgagaacg  120
gctgaagaa  gcatacaga  agttagcca  ggaatatca  cctgataag  atccaaatg  180
aggagacaa  tttaaagaa  taagttttg  atatgaagt  ctatcaaat  ctgagaagc  240
tgagttata  gacagatac  gagagcaag  tcttcggga  ggcagcggc  gaggtggtg  300
catggatga  attttctct  acatttttg  tgggggatt  ttcggcttc  tgggcaatc  360
gagtagaag  cgaaatggc  gaagaagag  agaggacat  atgcatcca  tcaaagtat  420
tttagaaga  ctgtataat  gcaagacaa  caaactaca  cttagcaag  atgtgctct  480
tagtgcatg  agtggccaa  gcggaaagt  tggagctgt  caaaagtgt  gtgcttgtc  540
aggtcgagg  gtgcgcatc  tgatcagac  gctggctcc  gggatggta  aacagatgc  600
gtctgtgtg  tctgattgt  atggagaag  agaggtaat  aatgaaaaa  accgctgta  660
aaaatgtga  gggaagaag  tgattaaag  agtcaagat  cttgaagtc  acgtagaca  720
aggcatgaa  catggacag  gaattacat  cactgggga  gcagaccag  ccccaggag  780
ggaacccgg  gacattgtt  ttttgctac  ggagaaaga  catgaggta  ttcagagag  840
tgggaatga  ttgcacatg  catataaaa  aggacttgt  gaagctcta  gtggatttc  900
gttcacatt  aagcacctt  atggacgtc  gattgtggt  aaatacccc  ctggcaaag  960
aattgaacc  gggtgtgtt  gtgtagttc  aggtgaagg  atgccgcag  atcgtaatc  1020
ctttgaaaa  ggtgatctt  acataaagt  tgatgtgca  tttcctgaa  acaactgga  1080
caacccaga  aagctttct  aactagaag  tcttctgcc  tctagaccg  aagttccta  1140
cataattgg  gaaacagag  aggtagagc  tcaggaatt  gatagcact  gaggctcag  1200
aggtggtca  aggcgtgaa  cctataatg  tagctctga  gaagaaagc  gcagccatc  1260
tggacctgg  gtgcagtgt  cccatcagt  aactctgca  acaaattgc  caggtggat  1320
ttctttcca  atttgcctg  tttgttctc  gcaatccag  tggagtgtc  tatcaatcc  1380
agatgaact  agggacatc  gttggtcta  gtataactt  taaaattgg  atagtatct  1440
cagagtgta  aatttaaac  aaccacaaa  ctttacatc  tcattttga  tgttccata  1500
caaaataaa  cacttgaaa  gaaacaaaa  tccctttca  acatggatt  ttataagtt  1560
caatcctgg  atctgtgct  gatttttat  agttttgtg  aaattttta  gtttcatat  1620
ttaaattta  atcccacat  gtaaagttt  tacaatttg  cctgaagct  tgtgtttgg  1680
tgcacctgc  taagctgct  caaataaaa  aaaaaattt  atagcctgt  tctatcatt  1740
aaatgcatg  aaaaaaatg  gctttgcac  caatgggtt  ggagctgac  gggaacaat  1800
gaaaaaatt  cattagctg  ggttgtaaa  tttttttgt  tttgggttt  gtttttttt  1860
tgttttttt  ttttttttt  ttaccattt  gtgaaaggt  tttgaaaat  gataataaa  1920
agcggttgg  gtaaattta  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  1980
aaaaaaaaa  aaa  1993



<210> 9170
<211> 412
<212> PRT
<213> Homo sapiens
<308> O60884
<400> 9170

Met Ala Asn Val Ala Asp Thr Lys Leu Tyr Asp Ile Leu Gly Val Pro 
  1               5                  10                  15
Pro Gly Ala Ser Glu Asn Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala 
             20                  25                  30
Lys Glu Tyr His Pro Asp Lys Asn Pro Asn Ala Gly Asp Lys Phe Lys 
         35                  40                  45
Glu Ile Ser Phe Ala Tyr Glu Val Leu Ser Asn Pro Glu Lys Arg Glu 
     50                  55                  60
Leu Tyr Asp Arg Tyr Gly Glu Gln Gly Leu Arg Glu Gly Ser Gly Gly 
 65                  70                  75                  80
Gly Gly Gly Met Asp Asp Ile Phe Ser His Ile Phe Gly Gly Gly Leu 
                 85                  90                  95
Phe Gly Phe Met Gly Asn Gln Ser Arg Ser Arg Asn Gly Arg Arg Arg 
             100                105                110
Gly Glu Asp Met Met His Pro Leu Lys Val Ser Leu Glu Asp Leu Tyr 
         115                120                125
Asn Gly Lys Thr Thr Lys Leu Gln Leu Ser Lys Asn Val Leu Cys Ser 
     130                135                140
Ala Cys Ser Gly Gln Gly Gly Lys Ser Gly Ala Val Gln Lys Cys Ser 
 145                150                155                160
Ala Cys Arg Gly Arg Gly Val Arg Ile Met Ile Arg Gln Leu Ala Pro 
                 165                170                175
Gly Met Val Gln Gln Met Gln Ser Val Cys Ser Asp Cys Asn Gly Glu 
             180                185                190
Gly Glu Val Ile Asn Glu Lys Asp Arg Cys Lys Lys Cys Glu Gly Lys 
         195                200                205
Lys Val Ile Lys Glu Val Lys Ile Leu Glu Val His Val Asp Lys Gly 
     210                215                220
Met Lys His Gly Gln Arg Ile Thr Phe Thr Gly Glu Ala Asp Gln Ala 
 225                230                235                240
Pro Gly Val Glu Pro Gly Asp Ile Val Leu Leu Leu Gln Glu Lys Glu 
                 245                250                255
His Glu Val Phe Gln Arg Asp Gly Asn Asp Leu His Met Thr Tyr Lys 
             260                265                270
Ile Gly Leu Val Glu Ala Leu Cys Gly Phe Gln Phe Thr Phe Lys His 
         275                280                285
Leu Asp Gly Arg Gln Ile Val Val Lys Tyr Pro Pro Gly Lys Val Ile 
     290                295                300
Glu Pro Gly Cys Val Arg Val Val Arg Gly Glu Gly Met Pro Gln Tyr 
 305                310                315                320
Arg Asn Pro Phe Glu Lys Gly Asp Leu Tyr Ile Lys Phe Asp Val Gln 
                 325                330                335
Phe Pro Glu Asn Asn Trp Ile Asn Pro Asp Lys Leu Ser Glu Leu Glu 
             340                345                350
Asp Leu Leu Pro Ser Arg Pro Glu Val Pro Asn Ile Ile Gly Glu Thr 
         355                360                365
Glu Glu Val Glu Leu Gln Glu Phe Asp Ser Thr Arg Gly Ser Gly Gly 
     370                375                380
Gly Gln Arg Arg Glu Ala Tyr Asn Asp Ser Ser Asp Glu Glu Ser Ser 
 385                390                395                400
Ser His His Gly Pro Gly Val Gln Cys Ala His Gln 
                 405                410



<210> 9171
<211> 1358
<212> DNA
<213> Rattus norvegicus
<308> U96130
<400> 9171

tccactgct  gtcactcac  cagtattcc  aatgtgtgt  catggatgc  gatactctg  60
ttctctcaa  tattgatga  ctttttgaa  gagaagaat  gtcagcagc  ccagaccca  120
ggtggcctg  ctgtttcaa  tctggagtc  ttgtctatc  accctcaat  gaaacgtat  180
accagctgt  gcatcttgc  tctgagcaa  gtagttttg  tggtgggga  cagggccta  240
tgaatacat  ttttagtgg  tgggcaacg  cagatatca  aaaacactt  ccatttgtg  300
ataacctga  cagcctctc  atatactcc  acctcccgg  atttaaagc  tttggtaaa  360
atgccaaag  tgtgcactt  ctgggacga  ccaagccat  gaattacac  tacaatccc  420
aaacaaaaa  tgtcaaatg  gaatcccag  acccaattg  gagtcaccc  gagtttctg  480
acctgtggt  ggacacctt  accaccaat  tcttacccc  gctccaaca  catggcctt  540
tcaaagatg  cggttccta  ctaatgatg  aacatgtca  aggagcctt  tcagacctg  600
cctttgggg  ggccccacc  gcatcacag  cttctttgt  ctcagaaga  aggaaggaa  660
ggtgggaac  gggccaggc  gattatatg  gagcagatt  ttttgataa  atcaagaga  720
aacttgaca  ttacctaca  tagaagcac  gccattttc  tgtggacac  tccatgtct  780
aggcacgtt  cgatacata  tatgtgaag  ctgttacaa  tgttagagg  tttcactaa  840
cctcagcag  tgaggggtt  gggcaggac  acaggtgag  actgggcaa  tgttattaa  900
taataattc  attatgtgg  caagtgttg  gtttaaccc  agacttttt  aaaaactct  960
aattcttaa  ttgccaatg  gtgataaag  aaagccaac  ttgagctac  aaattaggc  1020
ctttcaaat  gtgcagaac  tgactctcc  tcttcaaaa  aaggtatga  attctccaa  1080
atttgcttg  tgtatcctt  actagacct  caatgtaga  ttgttcaaa  cctgtcaga  1140
aagtagcct  ctagactaa  gtggccttt  ttaacactg  ggagtgatt  ataagccta  1200
cagctagtg  tagttcacc  gttttctat  caccatgaa  gcggcatgc  gacctgctc  1260
ttctcagtt  tctacttga  aattgcagt  tgctctctg  tggtagctg  ggaagcact  1320
tgtataaca  ataaagact  attgacata  aaaaaaaa  1358



<210> 9172
<211> 332
<212> PRT
<213> Rattus norvegicus
<308> O08730
<400> 9172

Thr Asp Gln Ala Phe Val Thr Leu Thr Thr Asn Asp Ala Tyr Ala Lys 
  1               5                  10                  15
Gly Ala Leu Val Leu Gly Ser Ser Leu Lys Gln His Arg Thr Thr Arg 
             20                  25                  30
Arg Thr Val Val Leu Ala Ser Pro Gln Val Ser Asp Ser Met Arg Lys 
         35                  40                  45
Val Leu Glu Thr Val Phe Asp Glu Val Ile Met Val Asp Val Leu Asp 
     50                  55                  60
Ser Gly Asp Ser Ala His Leu Thr Leu Met Lys Arg Pro Glu Leu Gly 
 65                  70                  75                  80
Ile Thr Leu Thr Lys Leu His Cys Trp Ser Leu Thr Gln Tyr Ser Lys 
                 85                  90                  95
Cys Val Phe Met Asp Ala Asp Thr Leu Val Leu Ser Asn Ile Asp Asp 
             100                105                110
Leu Phe Glu Arg Glu Glu Leu Ser Ala Ala Pro Asp Pro Gly Trp Pro 
         115                120                125
Asp Cys Phe Asn Ser Gly Val Phe Val Tyr Gln Pro Ser Ile Glu Thr 
     130                135                140
Tyr Asn Gln Leu Leu His Leu Ala Ser Glu Gln Gly Ser Phe Asp Gly 
 145                150                155                160
Gly Asp Gln Gly Leu Leu Asn Thr Tyr Phe Ser Gly Trp Ala Thr Thr 
                 165                170                175
Asp Ile Thr Lys His Leu Pro Phe Val Tyr Asn Leu Ser Ser Leu Ser 
             180                185                190
Ile Tyr Ser Tyr Leu Pro Ala Phe Lys Ala Phe Gly Lys Asn Ala Lys 
         195                200                205
Val Val His Phe Leu Gly Arg Thr Lys Pro Trp Asn Tyr Thr Tyr Asn 
     210                215                220
Pro Gln Thr Lys Ser Val Lys Cys Glu Ser Gln Asp Pro Ile Val Ser 
 225                230                235                240
His Pro Glu Phe Leu Asn Leu Trp Trp Asp Thr Phe Thr Thr Asn Val 
                 245                250                255
Leu Pro Leu Leu Gln His His Gly Leu Val Lys Asp Ala Gly Ser Tyr 
             260                265                270
Leu Met Met Glu His Val Thr Gly Ala Leu Ser Asp Leu Ser Phe Gly 
         275                280                285
Glu Ala Pro Pro Ala Ser Gln Pro Ser Leu Ser Ser Glu Glu Arg Lys 
     290                295                300
Glu Arg Trp Glu Gln Gly Gln Ala Asp Tyr Met Gly Ala Asp Ser Phe 
 305                310                315                320
Asp Asn Ile Lys Arg Lys Leu Asp Thr Tyr Leu Gln 
                 325                330



<210> 9173
<211> 1563
<212> DNA
<213> Homo sapiens
<308> X79537
<400> 9173

gctggccgc  ctccctccc  gtgccggct  ctctgagtc  ccaacctga  gctgccccg  60
ccgcctgcg  acccggcag  accatgaca  atcaggcct  tgtgacact  accacaaac  120
atgcctacg  caaaggtgc  ctggtcctg  gatcatctc  gaaacagca  aggaccacc  180
ggaggctgg  cgtgctcgc  acccctcag  tctcagact  catgagaaa  gttttagag  240
cagtctttg  tgaagtcat  atggtagat  tcttggaca  tggcgattc  gctcatcta  300
ccttaatga  gaggccaga  ttgggtgtc  cgctgacaa  gctccactg  tggtcgctt  360
cacagtatt  aaaatgtgt  ttcatggat  cagatactc  ggtcctagc  aatattgat  420
atctttttg  cagagaaga  ttgtcagca  caccagacc  agggtggcc  gactgcttc  480
attccggag  cttcgttta  cagccttca  ttgaaacat  caatcagct  ttgcatctt  540
cttctgagc  aggtagttt  gatggtggg  accaaggca  actgaacac  ttttttagc  600
gctgggcaa  aacagatat  agaaaacac  tgccgttta  ttataacct  agcagcatc  660
ctatatact  ctacctccc  gcatttaaa  tgaagatgt  tcaggagcc  tatcacatc  720
gtcccttgg  gagatccca  ctatggcac  gccgtttgt  tcctcggaa  aacggaagg  780
acgatggga  cagggccag  ctgattata  gggagcaga  tcctttgac  acatcaaga  840
gaaacttga  acttacctc  agtagaaac  ctgcatttt  ctgtgaaca  atccacttc  900
caagccttg  ttctgatac  tagtatcta  agctgggtt  agaaaagtc  gttacagtt  960
ctagaggtt  tcattaaaa  ttatcagat  agaggcttt  ttaggataa  aggtgagaa  1020
tgggcaaaa  ttgtgaagc  gcaattctg  tatatggac  gtgttctgc  ttttaatcc  1080
atttagctt  tttcagaaa  tctcacttt  gttgactgc  aacatacaa  gtaagggaa  1140
ctcaagata  taagatggc  gtatcagtt  ttaaaatct  cagagcctg  ttcaaaatc  1200
gtcactccc  tcagaagca  acatggcat  tgttccttg  ttgcttgtt  gttgtgtac  1260
tttcacgag  cctgaattt  agaattgcc  agtgctgcc  gagtgagtg  gtgtaattc  1320
cctttcagg  aaagatagg  tatctcaac  ctgctgagt  attcataaa  atatcaacc  1380
atagcatta  cccatttta  ttcctgtcc  tagtgtctg  agatgctca  cagttttct  1440
tgtacagta  ggcagcatg  taaaatgct  ttgttcagt  ctgtatatt  gaaaatagc  1500
gtgtgttct  tgatggtta  ctgcagtgg  accctgtac  aaaaataaa  gacttattg  1560
tgt  1563



<210> 9174
<211> 349
<212> PRT
<213> Homo sapiens
<308> P46976
<400> 9174

Thr Asp Gln Ala Phe Val Thr Leu Thr Thr Asn Asp Ala Tyr Ala Lys 
  1               5                  10                  15
Gly Ala Leu Val Leu Gly Ser Ser Leu Lys Gln His Arg Thr Thr Arg 
             20                  25                  30
Arg Leu Val Val Leu Ala Thr Pro Gln Val Ser Asp Ser Met Arg Lys 
         35                  40                  45
Val Leu Glu Thr Val Phe Asp Glu Val Ile Met Val Asp Val Leu Asp 
     50                  55                  60
Ser Gly Asp Ser Ala His Leu Thr Leu Met Lys Arg Pro Glu Leu Gly 
 65                  70                  75                  80
Val Thr Leu Thr Lys Leu His Cys Trp Ser Leu Thr Gln Tyr Ser Lys 
                 85                  90                  95
Cys Val Phe Met Asp Ala Asp Thr Leu Val Leu Ala Asn Ile Asp Asp 
             100                105                110
Leu Phe Asp Arg Glu Glu Leu Ser Ala Ala Pro Asp Pro Gly Trp Pro 
         115                120                125
Asp Cys Phe Asn Ser Gly Val Phe Val Tyr Gln Pro Ser Val Glu Thr 
     130                135                140
Tyr Asn Gln Leu Leu His Leu Ala Ser Glu Gln Gly Ser Phe Asp Gly 
 145                150                155                160
Gly Asp Gln Gly Ile Leu Asn Thr Phe Phe Ser Ser Trp Ala Thr Thr 
                 165                170                175
Asp Ile Arg Lys His Leu Pro Phe Ile Tyr Asn Leu Ser Ser Ile Ser 
             180                185                190
Ile Tyr Ser Tyr Leu Pro Ala Phe Lys Val Phe Gly Ala Ser Ala Lys 
         195                200                205
Val Val His Phe Leu Gly Arg Val Lys Pro Trp Asn Tyr Thr Tyr Asp 
     210                215                220
Pro Lys Thr Lys Ser Val Lys Ser Glu Ala His Asp Pro Asn Met Thr 
 225                230                235                240
His Pro Glu Phe Leu Ile Leu Trp Trp Asn Ile Phe Thr Thr Asn Val 
                 245                250                255
Leu Pro Leu Leu Gln Gln Phe Gly Leu Val Lys Asp Thr Cys Ser Tyr 
             260                265                270
Val Asn Val Leu Ser Asp Leu Val Tyr Thr Leu Ala Phe Ser Cys Gly 
         275                280                285
Phe Cys Arg Lys Glu Asp Val Ser Gly Ala Ile Ser His Leu Ser Leu 
     290                295                300
Gly Glu Ile Pro Ala Met Ala Gln Pro Phe Val Ser Ser Glu Glu Arg 
 305                310                315                320
Lys Glu Arg Trp Glu Gln Gly Gln Ala Asp Tyr Met Gly Ala Asp Ser 
                 325                330                335
Phe Asp Asn Ile Lys Arg Lys Leu Asp Thr Tyr Leu Gln 
             340                345



<210> 9175
<211> 1358
<212> DNA
<213> Rattus norvegicus
<308> U96130
<400> 9175

tccactgct  gtcactcac  cagtattcc  aatgtgtgt  catggatgc  gatactctg  60
ttctctcaa  tattgatga  ctttttgaa  gagaagaat  gtcagcagc  ccagaccca  120
ggtggcctg  ctgtttcaa  tctggagtc  ttgtctatc  accctcaat  gaaacgtat  180
accagctgt  gcatcttgc  tctgagcaa  gtagttttg  tggtgggga  cagggccta  240
tgaatacat  ttttagtgg  tgggcaacg  cagatatca  aaaacactt  ccatttgtg  300
ataacctga  cagcctctc  atatactcc  acctcccgg  atttaaagc  tttggtaaa  360
atgccaaag  tgtgcactt  ctgggacga  ccaagccat  gaattacac  tacaatccc  420
aaacaaaaa  tgtcaaatg  gaatcccag  acccaattg  gagtcaccc  gagtttctg  480
acctgtggt  ggacacctt  accaccaat  tcttacccc  gctccaaca  catggcctt  540
tcaaagatg  cggttccta  ctaatgatg  aacatgtca  aggagcctt  tcagacctg  600
cctttgggg  ggccccacc  gcatcacag  cttctttgt  ctcagaaga  aggaaggaa  660
ggtgggaac  gggccaggc  gattatatg  gagcagatt  ttttgataa  atcaagaga  720
aacttgaca  ttacctaca  tagaagcac  gccattttc  tgtggacac  tccatgtct  780
aggcacgtt  cgatacata  tatgtgaag  ctgttacaa  tgttagagg  tttcactaa  840
cctcagcag  tgaggggtt  gggcaggac  acaggtgag  actgggcaa  tgttattaa  900
taataattc  attatgtgg  caagtgttg  gtttaaccc  agacttttt  aaaaactct  960
aattcttaa  ttgccaatg  gtgataaag  aaagccaac  ttgagctac  aaattaggc  1020
ctttcaaat  gtgcagaac  tgactctcc  tcttcaaaa  aaggtatga  attctccaa  1080
atttgcttg  tgtatcctt  actagacct  caatgtaga  ttgttcaaa  cctgtcaga  1140
aagtagcct  ctagactaa  gtggccttt  ttaacactg  ggagtgatt  ataagccta  1200
cagctagtg  tagttcacc  gttttctat  caccatgaa  gcggcatgc  gacctgctc  1260
ttctcagtt  tctacttga  aattgcagt  tgctctctg  tggtagctg  ggaagcact  1320
tgtataaca  ataaagact  attgacata  aaaaaaaa  1358



<210> 9176
<211> 332
<212> PRT
<213> Rattus norvegicus
<308> O08730
<400> 9176

Thr Asp Gln Ala Phe Val Thr Leu Thr Thr Asn Asp Ala Tyr Ala Lys 
  1               5                  10                  15
Gly Ala Leu Val Leu Gly Ser Ser Leu Lys Gln His Arg Thr Thr Arg 
             20                  25                  30
Arg Thr Val Val Leu Ala Ser Pro Gln Val Ser Asp Ser Met Arg Lys 
         35                  40                  45
Val Leu Glu Thr Val Phe Asp Glu Val Ile Met Val Asp Val Leu Asp 
     50                  55                  60
Ser Gly Asp Ser Ala His Leu Thr Leu Met Lys Arg Pro Glu Leu Gly 
 65                  70                  75                  80
Ile Thr Leu Thr Lys Leu His Cys Trp Ser Leu Thr Gln Tyr Ser Lys 
                 85                  90                  95
Cys Val Phe Met Asp Ala Asp Thr Leu Val Leu Ser Asn Ile Asp Asp 
             100                105                110
Leu Phe Glu Arg Glu Glu Leu Ser Ala Ala Pro Asp Pro Gly Trp Pro 
         115                120                125
Asp Cys Phe Asn Ser Gly Val Phe Val Tyr Gln Pro Ser Ile Glu Thr 
     130                135                140
Tyr Asn Gln Leu Leu His Leu Ala Ser Glu Gln Gly Ser Phe Asp Gly 
 145                150                155                160
Gly Asp Gln Gly Leu Leu Asn Thr Tyr Phe Ser Gly Trp Ala Thr Thr 
                 165                170                175
Asp Ile Thr Lys His Leu Pro Phe Val Tyr Asn Leu Ser Ser Leu Ser 
             180                185                190
Ile Tyr Ser Tyr Leu Pro Ala Phe Lys Ala Phe Gly Lys Asn Ala Lys 
         195                200                205
Val Val His Phe Leu Gly Arg Thr Lys Pro Trp Asn Tyr Thr Tyr Asn 
     210                215                220
Pro Gln Thr Lys Ser Val Lys Cys Glu Ser Gln Asp Pro Ile Val Ser 
 225                230                235                240
His Pro Glu Phe Leu Asn Leu Trp Trp Asp Thr Phe Thr Thr Asn Val 
                 245                250                255
Leu Pro Leu Leu Gln His His Gly Leu Val Lys Asp Ala Gly Ser Tyr 
             260                265                270
Leu Met Met Glu His Val Thr Gly Ala Leu Ser Asp Leu Ser Phe Gly 
         275                280                285
Glu Ala Pro Pro Ala Ser Gln Pro Ser Leu Ser Ser Glu Glu Arg Lys 
     290                295                300
Glu Arg Trp Glu Gln Gly Gln Ala Asp Tyr Met Gly Ala Asp Ser Phe 
 305                310                315                320
Asp Asn Ile Lys Arg Lys Leu Asp Thr Tyr Leu Gln 
                 325                330



<210> 9177
<211> 1563
<212> DNA
<213> Homo sapiens
<308> X79537
<400> 9177

gctggccgc  ctccctccc  gtgccggct  ctctgagtc  ccaacctga  gctgccccg  60
ccgcctgcg  acccggcag  accatgaca  atcaggcct  tgtgacact  accacaaac  120
atgcctacg  caaaggtgc  ctggtcctg  gatcatctc  gaaacagca  aggaccacc  180
ggaggctgg  cgtgctcgc  acccctcag  tctcagact  catgagaaa  gttttagag  240
cagtctttg  tgaagtcat  atggtagat  tcttggaca  tggcgattc  gctcatcta  300
ccttaatga  gaggccaga  ttgggtgtc  cgctgacaa  gctccactg  tggtcgctt  360
cacagtatt  aaaatgtgt  ttcatggat  cagatactc  ggtcctagc  aatattgat  420
atctttttg  cagagaaga  ttgtcagca  caccagacc  agggtggcc  gactgcttc  480
attccggag  cttcgttta  cagccttca  ttgaaacat  caatcagct  ttgcatctt  540
cttctgagc  aggtagttt  gatggtggg  accaaggca  actgaacac  ttttttagc  600
gctgggcaa  aacagatat  agaaaacac  tgccgttta  ttataacct  agcagcatc  660
ctatatact  ctacctccc  gcatttaaa  tgaagatgt  tcaggagcc  tatcacatc  720
gtcccttgg  gagatccca  ctatggcac  gccgtttgt  tcctcggaa  aacggaagg  780
acgatggga  cagggccag  ctgattata  gggagcaga  tcctttgac  acatcaaga  840
gaaacttga  acttacctc  agtagaaac  ctgcatttt  ctgtgaaca  atccacttc  900
caagccttg  ttctgatac  tagtatcta  agctgggtt  agaaaagtc  gttacagtt  960
ctagaggtt  tcattaaaa  ttatcagat  agaggcttt  ttaggataa  aggtgagaa  1020
tgggcaaaa  ttgtgaagc  gcaattctg  tatatggac  gtgttctgc  ttttaatcc  1080
atttagctt  tttcagaaa  tctcacttt  gttgactgc  aacatacaa  gtaagggaa  1140
ctcaagata  taagatggc  gtatcagtt  ttaaaatct  cagagcctg  ttcaaaatc  1200
gtcactccc  tcagaagca  acatggcat  tgttccttg  ttgcttgtt  gttgtgtac  1260
tttcacgag  cctgaattt  agaattgcc  agtgctgcc  gagtgagtg  gtgtaattc  1320
cctttcagg  aaagatagg  tatctcaac  ctgctgagt  attcataaa  atatcaacc  1380
atagcatta  cccatttta  ttcctgtcc  tagtgtctg  agatgctca  cagttttct  1440
tgtacagta  ggcagcatg  taaaatgct  ttgttcagt  ctgtatatt  gaaaatagc  1500
gtgtgttct  tgatggtta  ctgcagtgg  accctgtac  aaaaataaa  gacttattg  1560
tgt  1563



<210> 9178
<211> 349
<212> PRT
<213> Homo sapiens
<308> P46976
<400> 9178

Thr Asp Gln Ala Phe Val Thr Leu Thr Thr Asn Asp Ala Tyr Ala Lys 
  1               5                  10                  15
Gly Ala Leu Val Leu Gly Ser Ser Leu Lys Gln His Arg Thr Thr Arg 
             20                  25                  30
Arg Leu Val Val Leu Ala Thr Pro Gln Val Ser Asp Ser Met Arg Lys 
         35                  40                  45
Val Leu Glu Thr Val Phe Asp Glu Val Ile Met Val Asp Val Leu Asp 
     50                  55                  60
Ser Gly Asp Ser Ala His Leu Thr Leu Met Lys Arg Pro Glu Leu Gly 
 65                  70                  75                  80
Val Thr Leu Thr Lys Leu His Cys Trp Ser Leu Thr Gln Tyr Ser Lys 
                 85                  90                  95
Cys Val Phe Met Asp Ala Asp Thr Leu Val Leu Ala Asn Ile Asp Asp 
             100                105                110
Leu Phe Asp Arg Glu Glu Leu Ser Ala Ala Pro Asp Pro Gly Trp Pro 
         115                120                125
Asp Cys Phe Asn Ser Gly Val Phe Val Tyr Gln Pro Ser Val Glu Thr 
     130                135                140
Tyr Asn Gln Leu Leu His Leu Ala Ser Glu Gln Gly Ser Phe Asp Gly 
 145                150                155                160
Gly Asp Gln Gly Ile Leu Asn Thr Phe Phe Ser Ser Trp Ala Thr Thr 
                 165                170                175
Asp Ile Arg Lys His Leu Pro Phe Ile Tyr Asn Leu Ser Ser Ile Ser 
             180                185                190
Ile Tyr Ser Tyr Leu Pro Ala Phe Lys Val Phe Gly Ala Ser Ala Lys 
         195                200                205
Val Val His Phe Leu Gly Arg Val Lys Pro Trp Asn Tyr Thr Tyr Asp 
     210                215                220
Pro Lys Thr Lys Ser Val Lys Ser Glu Ala His Asp Pro Asn Met Thr 
 225                230                235                240
His Pro Glu Phe Leu Ile Leu Trp Trp Asn Ile Phe Thr Thr Asn Val 
                 245                250                255
Leu Pro Leu Leu Gln Gln Phe Gly Leu Val Lys Asp Thr Cys Ser Tyr 
             260                265                270
Val Asn Val Leu Ser Asp Leu Val Tyr Thr Leu Ala Phe Ser Cys Gly 
         275                280                285
Phe Cys Arg Lys Glu Asp Val Ser Gly Ala Ile Ser His Leu Ser Leu 
     290                295                300
Gly Glu Ile Pro Ala Met Ala Gln Pro Phe Val Ser Ser Glu Glu Arg 
 305                310                315                320
Lys Glu Arg Trp Glu Gln Gly Gln Ala Asp Tyr Met Gly Ala Asp Ser 
                 325                330                335
Phe Asp Asn Ile Lys Arg Lys Leu Asp Thr Tyr Leu Gln 
             340                345



<210> 9179
<211> 1047
<212> DNA
<213> Rattus norvegicus
<308> U96490
<400> 9179

tttgggcag  acaaggcaa  agaagcggc  gtttcagta  tgtttgtac  cagaactca  60
cgaggtcta  ccttgggta  agcgaacgt  cggccatgg  ttaccactc  ggatatgga  120
tccacggtt  caagcatag  acccgggca  ctccaaacc  tcctccact  ttcgatgat  180
caagtggtg  ttattccag  caactaggc  gatacccag  cccaggagc  gatgtagcc  240
tcaatgtca  caacctgct  ggagaccca  tggccaata  ggctatggc  catggcagc  300
ccatagcat  ccaagggaa  gacatagtg  acaaagagc  acaccgttt  gtgtctata  360
acaaactca  gtatttttt  gctgtggac  cagcctatg  agccaagaa  ctagggcta  420
tggtcttcc  ttacacaca  cagaactgg  aagtgcagt  cagtcatga  gtgcctctt  480
cccccacgg  aagacctca  tgcgcctga  ctctatatc  ccaccatgg  cttcataac  540
tacgtgctg  tggctggga  ggcactagg  attcagaaa  ggttctccc  acagcatgt  600
gggctttgt  agcgagaca  gtactggtg  gggtgttaa  ggagtgttg  ctctgcttc  660
ggcctctac  tggccaccg  acgcagtga  ctgggcacc  tccacctct  ggcctagac  720
ggctacaag  atgtaggga  gatcctcag  gtgctcaca  ggctagctt  tcggcagtg  780
tggctacta  gtggccctg  cctggacat  gtctgcact  atgtacttc  ctgtagatc  840
ttgcggact  cagcttggg  cctgacagc  tggggggcc  acccctcgg  agcatctcc  900
gctgtacct  accctggga  ccgctgcct  caacccctt  tgatatact  gctgacctt  960
cacctggtc  ggtgacccc  ggtcctttg  tggcactga  ttttccata  attgaagat  1020
tggtttcct  aaaaaaaaa  aaaaaaa  1047



<210> 9180
<211> 137
<212> PRT
<213> Rattus norvegicus
<308> AAB68777
<400> 9180

Met Ala Tyr His Ser Gly Tyr Gly Val His Gly Ser Lys His Arg Thr 
  1               5                  10                  15
Arg Ala Ala Pro Asn Pro Pro Pro Leu Phe Asp Asp Thr Ser Gly Gly 
             20                  25                  30
Tyr Ser Ser Gln Leu Gly Gly Tyr Pro Ala Pro Gly Ala Asp Val Ala 
         35                  40                  45
Phe Asn Val Asn Asn Leu Leu Gly Asp Pro Val Ala Asn Met Ala Met 
     50                  55                  60
Ala His Gly Ser Ser Ile Ala Ser Gln Gly Lys Asp Ile Val His Lys 
 65                  70                  75                  80
Glu Leu His Arg Phe Val Ser Ile Asn Lys Leu Lys Tyr Phe Phe Ala 
                 85                  90                  95
Val Asp Thr Ala Tyr Val Ala Lys Lys Leu Gly Leu Leu Val Phe Pro 
             100                105                110
Tyr Thr His Gln Asn Trp Lys Val Gln Tyr Ser His Asp Val Pro Leu 
         115                120                125
Ala Pro Thr Glu Arg Pro Gln Cys Ala 
     130                135



<210> 9181
<211> 1096
<212> DNA
<213> Homo sapiens
<308> BC001299
<400> 9181

ccggcgggg  gggggacgt  tcgcgaggc  gggtggcct  ggtcggtac  ctgggcgcg  60
agcagctgc  tcattagta  tcgtaccca  gaggcggcg  agcgggccc  cggggacag  120
gagcgtcgc  gccatggct  atcactcgg  ctacggagc  cacggctcc  agcacaggg  180
ccgggcagc  ccggatccc  ctcccctct  cgatgacac  agcggtggt  attccagcc  240
gcccggggg  tacccagcc  caggagcag  cgtggcctt  agtgtcaac  acttgcttg  300
ggacccaat  gccaatgtg  ctatggcct  tggcagctc  atcgcatcc  atgggaagg  360
catggtgca  aaggagctg  accgttttg  gtctgtgag  aaactcaag  atttttttg  420
tgtggacac  gcctacgtg  ccaagaagc  agggctgct  gtcttcccc  acacacacc  480
gaactggga  gtgcagtac  gtcgtgatg  tcctctgcc  ccccggcaa  acctcaacg  540
ccctgacct  tatatcccc  cgatggcct  cattactta  gtgctcctg  ctgggatgg  600
actgggcat  cagaaaagg  tctccccgg  ggtgctggg  ctgtgtgca  gcacagcgc  660
ggtgtgggt  gtgatggag  tgctggccc  gctcctggg  ctctacctg  ccaccgtgc  720
cagtgacct  agcaccttt  acctgctgg  ctacagtgg  tacaaatac  tgggaatga  780
cctcagtgt  ctcacgggg  tgctgttcg  cagcgatgg  tactacgtg  cgctggcct  840
gacctcatc  gcgctcatg  acttcattg  gcgctcttt  cggacagca  ccctgggcc  900
cgacagcat  gggggcccc  tcccccggc  gcgtctcca  ctctacctg  ctctgggag  960
tgcagcctt  cagcccctc  tcatatact  gctgacttt  cacctggtc  ggtgacccc  1020
tggccccag  tggcactga  tttttcatt  attgaagat  tgatttcct  gaaaaaaaa  1080
aaaaaaaaa  aaaaaa  1096



<210> 9182
<211> 293
<212> PRT
<213> Homo sapiens
<308> NP_065203
<400> 9182

Met Ala Tyr His Ser Gly Tyr Gly Ala His Gly Ser Lys His Arg Ala 
  1               5                  10                  15
Arg Ala Ala Pro Asp Pro Pro Pro Leu Phe Asp Asp Thr Ser Gly Gly 
             20                  25                  30
Tyr Ser Ser Gln Pro Gly Gly Tyr Pro Ala Thr Gly Ala Asp Val Ala 
         35                  40                  45
Phe Ser Val Asn His Leu Leu Gly Asp Pro Met Ala Asn Val Ala Met 
     50                  55                  60
Ala Tyr Gly Ser Ser Ile Ala Ser His Gly Lys Asp Met Val His Lys 
 65                  70                  75                  80
Glu Leu His Arg Phe Val Ser Val Ser Lys Leu Lys Tyr Phe Phe Ala 
                 85                  90                  95
Val Asp Thr Ala Tyr Val Ala Lys Lys Leu Gly Leu Leu Val Phe Pro 
             100                105                110
Tyr Thr His Gln Asn Trp Glu Val Gln Tyr Ser Arg Asp Ala Pro Leu 
         115                120                125
Pro Pro Arg Gln Asp Leu Asn Ala Pro Asp Leu Tyr Ile Pro Thr Lys 
     130                135                140
Ala Phe Ile Thr Tyr Val Leu Leu Ala Gly Met Ala Leu Gly Ile Gln 
 145                150                155                160
Lys Arg Phe Ser Pro Glu Val Leu Gly Leu Cys Ala Ser Thr Ala Leu 
                 165                170                175
Val Trp Val Val Met Glu Val Leu Ala Leu Leu Leu Gly Leu Tyr Leu 
             180                185                190
Ala Thr Val Arg Ser Asp Leu Ser Thr Phe His Leu Leu Ala Tyr Ser 
         195                200                205
Gly Tyr Lys Tyr Val Gly Met Ile Leu Ser Val Leu Thr Gly Leu Leu 
     210                215                220
Phe Gly Ser Asp Gly Tyr Tyr Val Ala Leu Ala Trp Thr Ser Ser Ala 
 225                230                235                240
Leu Met Tyr Phe Ile Val Arg Ser Leu Arg Thr Ala Ala Leu Gly Pro 
                 245                250                255
Asp Ser Met Gly Gly Pro Val Pro Arg Gln Arg Leu Gln Leu Tyr Leu 
             260                265                270
Thr Leu Gly Ala Ala Ala Phe Gln Pro Leu Ile Ile Tyr Trp Leu Thr 
         275                280                285
Phe His Leu Val Arg 
     290



<210> 9183
<211> 1047
<212> DNA
<213> Rattus norvegicus
<308> U96490
<400> 9183

tttgggcag  acaaggcaa  agaagcggc  gtttcagta  tgtttgtac  cagaactca  60
cgaggtcta  ccttgggta  agcgaacgt  cggccatgg  ttaccactc  ggatatgga  120
tccacggtt  caagcatag  acccgggca  ctccaaacc  tcctccact  ttcgatgat  180
caagtggtg  ttattccag  caactaggc  gatacccag  cccaggagc  gatgtagcc  240
tcaatgtca  caacctgct  ggagaccca  tggccaata  ggctatggc  catggcagc  300
ccatagcat  ccaagggaa  gacatagtg  acaaagagc  acaccgttt  gtgtctata  360
acaaactca  gtatttttt  gctgtggac  cagcctatg  agccaagaa  ctagggcta  420
tggtcttcc  ttacacaca  cagaactgg  aagtgcagt  cagtcatga  gtgcctctt  480
cccccacgg  aagacctca  tgcgcctga  ctctatatc  ccaccatgg  cttcataac  540
tacgtgctg  tggctggga  ggcactagg  attcagaaa  ggttctccc  acagcatgt  600
gggctttgt  agcgagaca  gtactggtg  gggtgttaa  ggagtgttg  ctctgcttc  660
ggcctctac  tggccaccg  acgcagtga  ctgggcacc  tccacctct  ggcctagac  720
ggctacaag  atgtaggga  gatcctcag  gtgctcaca  ggctagctt  tcggcagtg  780
tggctacta  gtggccctg  cctggacat  gtctgcact  atgtacttc  ctgtagatc  840
ttgcggact  cagcttggg  cctgacagc  tggggggcc  acccctcgg  agcatctcc  900
gctgtacct  accctggga  ccgctgcct  caacccctt  tgatatact  gctgacctt  960
cacctggtc  ggtgacccc  ggtcctttg  tggcactga  ttttccata  attgaagat  1020
tggtttcct  aaaaaaaaa  aaaaaaa  1047



<210> 9184
<211> 137
<212> PRT
<213> Rattus norvegicus
<308> AAB68777
<400> 9184

Met Ala Tyr His Ser Gly Tyr Gly Val His Gly Ser Lys His Arg Thr 
  1               5                  10                  15
Arg Ala Ala Pro Asn Pro Pro Pro Leu Phe Asp Asp Thr Ser Gly Gly 
             20                  25                  30
Tyr Ser Ser Gln Leu Gly Gly Tyr Pro Ala Pro Gly Ala Asp Val Ala 
         35                  40                  45
Phe Asn Val Asn Asn Leu Leu Gly Asp Pro Val Ala Asn Met Ala Met 
     50                  55                  60
Ala His Gly Ser Ser Ile Ala Ser Gln Gly Lys Asp Ile Val His Lys 
 65                  70                  75                  80
Glu Leu His Arg Phe Val Ser Ile Asn Lys Leu Lys Tyr Phe Phe Ala 
                 85                  90                  95
Val Asp Thr Ala Tyr Val Ala Lys Lys Leu Gly Leu Leu Val Phe Pro 
             100                105                110
Tyr Thr His Gln Asn Trp Lys Val Gln Tyr Ser His Asp Val Pro Leu 
         115                120                125
Ala Pro Thr Glu Arg Pro Gln Cys Ala 
     130                135



<210> 9185
<211> 1096
<212> DNA
<213> Homo sapiens
<308> BC001299
<400> 9185

ccggcgggg  gggggacgt  tcgcgaggc  gggtggcct  ggtcggtac  ctgggcgcg  60
agcagctgc  tcattagta  tcgtaccca  gaggcggcg  agcgggccc  cggggacag  120
gagcgtcgc  gccatggct  atcactcgg  ctacggagc  cacggctcc  agcacaggg  180
ccgggcagc  ccggatccc  ctcccctct  cgatgacac  agcggtggt  attccagcc  240
gcccggggg  tacccagcc  caggagcag  cgtggcctt  agtgtcaac  acttgcttg  300
ggacccaat  gccaatgtg  ctatggcct  tggcagctc  atcgcatcc  atgggaagg  360
catggtgca  aaggagctg  accgttttg  gtctgtgag  aaactcaag  atttttttg  420
tgtggacac  gcctacgtg  ccaagaagc  agggctgct  gtcttcccc  acacacacc  480
gaactggga  gtgcagtac  gtcgtgatg  tcctctgcc  ccccggcaa  acctcaacg  540
ccctgacct  tatatcccc  cgatggcct  cattactta  gtgctcctg  ctgggatgg  600
actgggcat  cagaaaagg  tctccccgg  ggtgctggg  ctgtgtgca  gcacagcgc  660
ggtgtgggt  gtgatggag  tgctggccc  gctcctggg  ctctacctg  ccaccgtgc  720
cagtgacct  agcaccttt  acctgctgg  ctacagtgg  tacaaatac  tgggaatga  780
cctcagtgt  ctcacgggg  tgctgttcg  cagcgatgg  tactacgtg  cgctggcct  840
gacctcatc  gcgctcatg  acttcattg  gcgctcttt  cggacagca  ccctgggcc  900
cgacagcat  gggggcccc  tcccccggc  gcgtctcca  ctctacctg  ctctgggag  960
tgcagcctt  cagcccctc  tcatatact  gctgacttt  cacctggtc  ggtgacccc  1020
tggccccag  tggcactga  tttttcatt  attgaagat  tgatttcct  gaaaaaaaa  1080
aaaaaaaaa  aaaaaa  1096



<210> 9186
<211> 293
<212> PRT
<213> Homo sapiens
<308> NP_065203
<400> 9186

Met Ala Tyr His Ser Gly Tyr Gly Ala His Gly Ser Lys His Arg Ala 
  1               5                  10                  15
Arg Ala Ala Pro Asp Pro Pro Pro Leu Phe Asp Asp Thr Ser Gly Gly 
             20                  25                  30
Tyr Ser Ser Gln Pro Gly Gly Tyr Pro Ala Thr Gly Ala Asp Val Ala 
         35                  40                  45
Phe Ser Val Asn His Leu Leu Gly Asp Pro Met Ala Asn Val Ala Met 
     50                  55                  60
Ala Tyr Gly Ser Ser Ile Ala Ser His Gly Lys Asp Met Val His Lys 
 65                  70                  75                  80
Glu Leu His Arg Phe Val Ser Val Ser Lys Leu Lys Tyr Phe Phe Ala 
                 85                  90                  95
Val Asp Thr Ala Tyr Val Ala Lys Lys Leu Gly Leu Leu Val Phe Pro 
             100                105                110
Tyr Thr His Gln Asn Trp Glu Val Gln Tyr Ser Arg Asp Ala Pro Leu 
         115                120                125
Pro Pro Arg Gln Asp Leu Asn Ala Pro Asp Leu Tyr Ile Pro Thr Lys 
     130                135                140
Ala Phe Ile Thr Tyr Val Leu Leu Ala Gly Met Ala Leu Gly Ile Gln 
 145                150                155                160
Lys Arg Phe Ser Pro Glu Val Leu Gly Leu Cys Ala Ser Thr Ala Leu 
                 165                170                175
Val Trp Val Val Met Glu Val Leu Ala Leu Leu Leu Gly Leu Tyr Leu 
             180                185                190
Ala Thr Val Arg Ser Asp Leu Ser Thr Phe His Leu Leu Ala Tyr Ser 
         195                200                205
Gly Tyr Lys Tyr Val Gly Met Ile Leu Ser Val Leu Thr Gly Leu Leu 
     210                215                220
Phe Gly Ser Asp Gly Tyr Tyr Val Ala Leu Ala Trp Thr Ser Ser Ala 
 225                230                235                240
Leu Met Tyr Phe Ile Val Arg Ser Leu Arg Thr Ala Ala Leu Gly Pro 
                 245                250                255
Asp Ser Met Gly Gly Pro Val Pro Arg Gln Arg Leu Gln Leu Tyr Leu 
             260                265                270
Thr Leu Gly Ala Ala Ala Phe Gln Pro Leu Ile Ile Tyr Trp Leu Thr 
         275                280                285
Phe His Leu Val Arg 
     290



<210> 9187
<211> 2787
<212> DNA
<213> Rattus norvegicus
<308> U97143
<400> 9187

ctccgcatt  gatttgggg  tcgctattg  tcggctgtt  ttattatcg  tattttatt  60
ttatttttt  aacctaagg  agaaagaca  atacacaca  aactgtggg  tttatttaa  120
atgatcttg  caaacgcct  ctgcctctt  ttcttttta  acgaaaccc  ccgctcttt  180
gccagccct  cctccctgc  gggctctga  ctccacggc  ggcgccccc  agtggactg  240
gtccgggcc  atgagctgt  tgcggctga  tccaactgc  gctccaggt  ccgcaccct  300
cggcagtgc  tggcaggcc  ggatcgcaa  accatgctg  ccaataagg  gtgccaggc  360
gccctggag  tcttgcagg  aagcccact  tatgactgc  gctgcaagc  gggcatgaa  420
aaggagctg  agtgtctgc  gatctactg  agcatccat  tggggctga  agagggtga  480
gagttctat  aagcttccc  ctatgagcc  gtgacctcg  gcctctcgg  catcttcag  540
ctcgcttca  tcttctcag  gacagggac  gacccggcg  tcagtacca  aagcaacca  600
tgcctggat  ccgccaagg  ctgcaacct  aatgacaac  gcaagaagc  tcgctcctc  660
tatatctcc  tctgcaacc  tgagatctc  cccaccgaa  gctgcaacc  ccgcaagtg  720
cacaaggct  tgcgccagt  ctttgaccg  gtgcccagc  agtatacct  ccgcatgct  780
ttctgctcc  gtcaggacc  ggcatgtgc  gagcgtcgc  ggcaaacca  cctgcccag  840
tgctcctat  aggacaagg  gaagcccaa  tgcctggac  tgcgcagcc  gtgtcgtac  900
gaccacctg  gccggtccc  actggcaga  ttccacgcc  actgtcgag  ctcctaccg  960
acaatcacc  gctgtcctg  ggacaacta  caggcatgt  tgggctcct  tgctggcat  1020
attgggttt  atatgacac  caactatgt  gactccaac  ccacgggca  cgtggtgtc  1080
ccctggtgc  attgtcgtg  cagtgggaa  atggaagaa  agtgtgaga  gttcctcag  1140
gacttcacg  aaaacccat  cctccggaa  gccattcag  cctttggta  tggcacaga  1200
gtgaacatg  ctcccaaag  cccctcact  ccagctacc  aggcccctc  ggtggagaa  1260
actccttca  tgccagatg  cctcagtga  agcaccagc  tggggacca  tgtcatcac  1320
acctgcaca  ctatccagg  gcaagggct  aaggccaac  actccaaag  gttaagcat  1380
tgcttcaca  agctcacga  aaacatcag  ccagggagt  aaaaggtga  caaacttaa  1440
tcaggctcc  gcagagcca  actgtcggc  gccttgact  ccctcccac  cctgatgct  1500
accttggcc  tgtaggcct  tggaaccca  cacaaaagt  cttcaagca  cccagatat  1560
aactcccgc  tgacaaaat  gaaacacac  catacacac  tgcacacac  cacacacac  1620
cacacacac  cacacacac  cacacacac  cacacaccc  ttgcaaaaa  acttttttt  1680
ctacattgt  tctgaacct  tctcctccc  agtttcttc  ctggagaag  ttttctaaa  1740
caaacagac  agcaggcgg  cagtcagaa  cctgcccag  ggtcccctg  aagggacac  1800
cagcaccaa  gagggctca  ggctcttga  agactcttt  ctcttcact  gtgttttct  1860
tctggacaa  atgagaccc  gatgtggaa  gtactttgc  gtgcctggt  tggactggg  1920
aaaggacag  tgcagctgc  tactctggg  acctgccca  gggttcaca  agagtctca  1980
tcagcaagg  agcagggct  gccacaagg  ctttgtcac  tcttcctct  ggcttcaga  2040
atggaaatg  tttgctgcc  tccccagcc  ttatgtggc  tagtgggtt  aagtctgga  2100
taggaagcc  catggcagc  tcaggccat  gtgcctgta  tatagctgg  gttgggagc  2160
gttacagga  gaagcttct  tggggcatg  gcaagcctt  gttgggcac  agctccaag  2220
tgtaccttc  tcctttatg  caggaatct  gaagtcaaa  agaaatgat  ctctgttgg  2280
tcttttttg  ttgtttttg  atttttttg  gggtccatt  ggcaggtct  tcttgggga  2340
aagggctgt  gagtggggc  ggggagacc  tagctgggc  tgtgtatgg  gcactctgg  2400
gggttccca  gcttgcccc  tctctcttc  tgtttctgc  ttctctctc  tttctgaga  2460
attcatgca  tgtctgtac  tactgggtc  cctttctca  catatgtgt  tatccatat  2520
catatatcc  atgatttta  tctttcttt  atttttttt  aagaaacaa  actatggaa  2580
taataccct  cagatgagc  aaaatgtat  attgtaaag  ttatttttt  taataatgt  2640
gtctatgat  ggaagaaag  taccaggac  cctgagccc  ggtccagtt  ggctggtgg  2700
gctgtggcc  gggactccc  attgcattc  ctcttaacc  agctccaat  aacgtacta  2760
gaagcgagt  gccctgtgc  tcaaaaa  2787



<210> 9188
<211> 464
<212> PRT
<213> Rattus norvegicus
<308> AAC53301
<400> 9188

Met Ile Leu Ala Asn Ala Phe Cys Leu Phe Phe Phe Leu Asp Glu Thr 
  1               5                  10                  15
Leu Arg Ser Leu Ala Ser Pro Ser Ser Leu Gln Gly Ser Glu Leu His 
             20                  25                  30
Gly Trp Arg Pro Gln Val Asp Cys Val Arg Ala Asn Glu Leu Cys Ala 
         35                  40                  45
Ala Glu Ser Asn Cys Ser Ser Arg Tyr Arg Thr Leu Arg Gln Cys Leu 
     50                  55                  60
Ala Gly Arg Asp Arg Asn Thr Met Leu Ala Asn Lys Glu Cys Gln Ala 
 65                  70                  75                  80
Ala Leu Glu Val Leu Gln Glu Ser Pro Leu Tyr Asp Cys Arg Cys Lys 
                 85                  90                  95
Arg Gly Met Lys Lys Glu Leu Gln Cys Leu Gln Ile Tyr Trp Ser Ile 
             100                105                110
His Leu Gly Leu Thr Glu Gly Glu Glu Phe Tyr Glu Ala Ser Pro Tyr 
         115                120                125
Glu Pro Val Thr Ser Arg Leu Ser Asp Ile Phe Arg Leu Ala Ser Ile 
     130                135                140
Phe Ser Gly Thr Gly Thr Asp Pro Ala Val Ser Thr Lys Ser Asn His 
 145                150                155                160
Cys Leu Asp Ala Ala Lys Ala Cys Asn Leu Asn Asp Asn Cys Lys Lys 
                 165                170                175
Leu Arg Ser Ser Tyr Ile Ser Ile Cys Asn Arg Glu Ile Ser Pro Thr 
             180                185                190
Glu Arg Cys Asn Arg Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe 
         195                200                205
Asp Arg Val Pro Ser Glu Tyr Thr Tyr Arg Met Leu Phe Cys Ser Cys 
     210                215                220
Gln Asp Gln Ala Cys Ala Glu Arg Arg Arg Gln Thr Ile Leu Pro Ser 
 225                230                235                240
Cys Ser Tyr Glu Asp Lys Glu Lys Pro Asn Cys Leu Asp Leu Arg Ser 
                 245                250                255
Leu Cys Arg Thr Asp His Leu Cys Arg Ser Arg Leu Ala Asp Phe His 
             260                265                270
Ala Asn Cys Arg Ala Ser Tyr Arg Thr Ile Thr Ser Cys Pro Ala Asp 
         275                280                285
Asn Tyr Gln Ala Cys Leu Gly Ser Tyr Ala Gly Met Ile Gly Phe Asp 
     290                295                300
Met Thr Pro Asn Tyr Val Asp Ser Asn Pro Thr Gly Ile Val Val Ser 
 305                310                315                320
Pro Trp Cys Asn Cys Arg Gly Ser Gly Asn Met Glu Glu Glu Cys Glu 
                 325                330                335
Lys Phe Leu Arg Asp Phe Thr Glu Asn Pro Cys Leu Arg Asn Ala Ile 
             340                345                350
Gln Ala Phe Gly Asn Gly Thr Asp Val Asn Met Ser Pro Lys Gly Pro 
         355                360                365
Ser Leu Pro Ala Thr Gln Ala Pro Arg Val Glu Lys Thr Pro Ser Leu 
     370                375                380
Pro Asp Asp Leu Ser Asp Ser Thr Ser Leu Gly Thr Ser Val Ile Thr 
 385                390                395                400
Thr Cys Thr Ser Ile Gln Glu Gln Gly Leu Lys Ala Asn Asn Ser Lys 
                 405                410                415
Glu Leu Ser Met Cys Phe Thr Glu Leu Thr Thr Asn Ile Ser Pro Gly 
             420                425                430
Ser Lys Lys Val Ile Lys Leu Asn Ser Gly Ser Ser Arg Ala Arg Leu 
         435                440                445
Ser Ala Ala Leu Thr Ala Leu Pro Leu Leu Met Leu Thr Leu Ala Leu 
     450                455                460



<210> 9189
<211> 2906
<212> DNA
<213> Homo sapiens
<308> U97145
<400> 9189

ttttttttt  tgattgtag  gggcaaggg  ggcgtcgag  ggcagcagc  catcgcccg  60
ctctcaccc  accccctcc  gccagaggc  agaatcgca  gactcggga  cttcatcgg  120
tggactagc  gggatctcc  cattggatt  ggggctgat  accactgct  ggctattat  180
attgttgtt  ttactacta  tattttttt  tacccaagg  agaaagaca  aaaaacggt  240
ggatttatt  aacatgatc  tggcaaacg  cttctgcct  ttcttcttt  tagacgaga  300
cctccgctc  ttggccagc  cttcctccc  gcagggccc  gagctccac  gctggcgcc  360
cccagtgga  tgtgtccgg  ccaatgagc  gtgtgccgc  gaatccaac  gcagctctc  420
ctaccgcac  ctgcggcag  gcctggcag  ccgcgaccg  aacaccatg  tggccaaca  480
ggagtgcca  gcggccttg  aggtcttgc  ggagagccc  ctgtacgac  gccgctgca  540
gcggggcat  aagaaggag  tgcagtgtc  gcagatcta  tggagcatc  acctggggc  600
gaccgaggg  gaggagttc  acgaagcct  cccctatga  ccggtgacc  cccgcctct  660
ggacatctt  aggcttgct  caatcttct  agggacagg  gcagacccg  tggtcagcg  720
caagagcaa  cattgcctg  atgctgcca  ggcctgcaa  ctgaatgac  actgcaaga  780
gctgcgctc  tcctacatc  ccatctgca  ccgcgagat  tcgcccacc  agcgctgca  840
ccgccgcaa  tgccacaag  ccctgcgcc  gttcttcga  cgggtgccc  gcgagtaca  900
ctaccgcat  ctcttctgc  cctgccaag  ccaggcgtg  gctgagcgc  gccggcaaa  960
catcctgcc  agctgctcc  atgaggaca  ggagaagcc  aactgcctg  acctgcgtg  1020
cgtgtgccg  actgaccac  tgtgtcggt  ccggctggc  gacttccat  ccaattgtc  1080
agcctccta  cagacggtc  ccagctgcc  tgcggacaa  taccaggcg  gtctgggct  1140
ttatgctgg  atgattggg  ttgacatga  acctaacta  gtggactcc  gccccactg  1200
catcgtggt  tccccctgg  gcagctgtc  tggcagcgg  aacatggag  aggagtgtg  1260
gaagttcct  agggacttc  ccgagaacc  atgcctccg  aacgccatc  aggcctttg  1320
caacggcac  gacgtgaac  tgtccccaa  aggcccctc  ttccaggcc  cccaggccc  1380
tcgggtgga  aagacgcct  ctttgccag  tgacctcag  gacagtacc  gcttgggga  1440
cagtgtcat  accacctgc  cgtctgtcc  ggagcaggg  ctgaaggcc  acaactcca  1500
agagttaag  atgtgcttc  cagagctca  gacaaatat  atcccaggg  gtaacaagg  1560
gatcaaacc  aactcaggc  ccagcagag  cagaccgtc  gctgccttg  ccgtgctgt  1620
tgtcctgat  ctgaaactg  ccttgtagg  tgtgggaac  gagtcagaa  atttttgaa  1680
gctacgcag  caagaacag  cgcctgacg  aatggaaac  cacacagac  cacacacac  1740
ttgcaaaaa  aaaattgtt  ttcccacct  gtcgctgaa  ctgtctcct  ccaggtttc  1800
tctctggag  agtttttgt  aaccaaaca  acaagcagg  aggcagcct  agagctggc  1860
caggggtcc  ctggcaggg  aaactctgg  gccggggag  gcacgaggc  ctagaaatg  1920
ccttcactt  ctcctggtg  ttttctctc  ggacccttc  gaagcagag  ccggacaag  1980
gcctgcagc  gaagggact  tgggctgtg  ctgaggctg  ctgggggca  gacaacaca  2040
ctgcttccc  aggctgccc  ctctgggga  ccgctgggg  ctggcagag  gcatcggtc  2100
gcggggcag  ggggctggc  atgagggtc  accttcagc  ctttggctt  aaggatgga  2160
atggttttg  cctccctct  tgccctcgg  tggggctgg  gggtctgca  ctggtgtgg  2220
aacttcccc  cggatggcg  tggaggggg  tcgcaccgt  ctgggctcc  cctgactgt  2280
gcacggagt  ttggggctg  gggccagct  caggagggc  tgagagctc  gcctgcctg  2340
gagagccct  gtggcgagg  attaaaact  gggcaccag  ttctttctc  gtggcagaa  2400
ttttgaagt  agagagaaa  ggtcctttg  tggcttctt  gctttctcg  gggtccttt  2460
gcaggcctc  ctttgggga  agggagggg  gagaccaca  ccgggtgtg  gtctgcagc  2520
ccgtgggcc  tcaagcttt  ctgctgtct  ctccctcct  ctcctttcc  ctttctctt  2580
cctcatttc  tagacgtac  tcaactgta  gtacatacc  gggctcctc  cctaacata  2640
atgtatata  acatccata  acatatatt  tgtggtttc  cctttcttt  cttttttta  2700
gcaacaaaa  tatggaaat  ataccccaa  agatgagcg  aaatgtatt  ttgtaaagt  2760
tattttttt  aatactgtt  tctataatg  ggaaaaagg  cattggccc  gcagtgccc  2820
gccccagtc  gcctggctg  gctctggtg  gggctcctg  tccgcatcc  agcttaacc  2880
aggctccaa  aaacgtgct  ggaagc  2906



<210> 9190
<211> 464
<212> PRT
<213> Homo sapiens
<308> O00451
<400> 9190

Met Ile Leu Ala Asn Val Phe Cys Leu Phe Phe Phe Leu Asp Glu Thr 
  1               5                  10                  15
Leu Arg Ser Leu Ala Ser Pro Ser Ser Leu Gln Gly Pro Glu Leu His 
             20                  25                  30
Gly Trp Arg Pro Pro Val Asp Cys Val Arg Ala Asn Glu Leu Cys Ala 
         35                  40                  45
Ala Glu Ser Asn Cys Ser Ser Arg Tyr Arg Thr Leu Arg Gln Cys Leu 
     50                  55                  60
Ala Gly Arg Asp Arg Asn Thr Met Leu Ala Asn Lys Glu Cys Gln Ala 
 65                  70                  75                  80
Ala Leu Glu Val Leu Gln Glu Ser Pro Leu Tyr Asp Cys Arg Cys Lys 
                 85                  90                  95
Arg Gly Met Lys Lys Glu Leu Gln Cys Leu Gln Ile Tyr Trp Ser Ile 
             100                105                110
His Leu Gly Leu Thr Glu Gly Glu Glu Phe Tyr Glu Ala Ser Pro Tyr 
         115                120                125
Glu Pro Val Thr Ser Arg Leu Ser Asp Ile Phe Arg Leu Ala Ser Ile 
     130                135                140
Phe Ser Gly Thr Gly Ala Asp Pro Val Val Ser Ala Lys Ser Asn His 
 145                150                155                160
Cys Leu Asp Ala Ala Lys Ala Cys Asn Leu Asn Asp Asn Cys Lys Lys 
                 165                170                175
Leu Arg Ser Ser Tyr Ile Ser Ile Cys Asn Arg Glu Ile Ser Pro Thr 
             180                185                190
Glu Arg Cys Asn Arg Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe 
         195                200                205
Asp Arg Val Pro Ser Glu Tyr Thr Tyr Arg Met Leu Phe Cys Ser Cys 
     210                215                220
Gln Asp Gln Ala Cys Ala Glu Arg Arg Arg Gln Thr Ile Leu Pro Ser 
 225                230                235                240
Cys Ser Tyr Glu Asp Lys Glu Lys Pro Asn Cys Leu Asp Leu Arg Gly 
                 245                250                255
Val Cys Arg Thr Asp His Leu Cys Arg Ser Arg Leu Ala Asp Phe His 
             260                265                270
Ala Asn Cys Arg Ala Ser Tyr Gln Thr Val Thr Ser Cys Pro Ala Asp 
         275                280                285
Asn Tyr Gln Ala Cys Leu Gly Ser Tyr Ala Gly Met Ile Gly Phe Asp 
     290                295                300
Met Thr Pro Asn Tyr Val Asp Ser Ser Pro Thr Gly Ile Val Val Ser 
 305                310                315                320
Pro Trp Cys Ser Cys Arg Gly Ser Gly Asn Met Glu Glu Glu Cys Glu 
                 325                330                335
Lys Phe Leu Arg Asp Phe Thr Glu Asn Pro Cys Leu Arg Asn Ala Ile 
             340                345                350
Gln Ala Phe Gly Asn Gly Thr Asp Val Asn Val Ser Pro Lys Gly Pro 
         355                360                365
Ser Phe Gln Ala Thr Gln Ala Pro Arg Val Glu Lys Thr Pro Ser Leu 
     370                375                380
Pro Asp Asp Leu Ser Asp Ser Thr Ser Leu Gly Thr Ser Val Ile Thr 
 385                390                395                400
Thr Cys Thr Ser Val Gln Glu Gln Gly Leu Lys Ala Asn Asn Ser Lys 
                 405                410                415
Glu Leu Ser Met Cys Phe Thr Glu Leu Thr Thr Asn Ile Ile Pro Gly 
             420                425                430
Ser Asn Lys Val Ile Lys Pro Asn Ser Gly Pro Ser Arg Ala Arg Pro 
         435                440                445
Ser Ala Ala Leu Thr Val Leu Ser Val Leu Met Leu Lys Gln Ala Leu 
     450                455                460



<210> 9191
<211> 1617
<212> DNA
<213> Rattus norvegicus
<308> V01227
<400> 9191

gcgctgtaa  aagcaacac  tcctcctcg  ctccgccat  cacccggca  ccgcgaagc  60
gcaaccatg  gtgagtgta  ctccatcca  gtcggccag  ctggtgtcc  gatcggcaa  120
gcctgctgg  agctctact  cctggaaca  ggcatccag  ctgatggcc  gatgccaag  180
gacaagacc  ttgggggag  agatgactc  ttcaacacc  tcttcagtg  gacaggagc  240
ggcaagcac  tgccccggg  ggtgttcgt  gacctggaa  ccacagtta  tgatgaagt  300
cgcactggc  cctaccgcc  gctcttcca  ccagagcag  tcatcacag  caaggaaga  360
gctgccaat  actatgccc  tggccacta  accattggc  aggagatca  tgaccttgt  420
ttggacaga  ttcgcaagc  ggctgacca  tgcacgggt  tccagggct  cttggtttt  480
cacagcttt  gtgggggaa  tggctctgg  ttcacctcc  tgctgatgg  gaggctctc  540
gtcgactac  gaaagaagt  caagctgga  ttctccatt  acccagccc  ccaggtttc  600
actgctgtg  ttgagccct  caattccat  ctcaccacc  acaccaccc  ggagcactc  660
gattgtgcc  tcatggtag  caatgaggc  atctatgac  tctgtcgta  aaacctcga  720
attgagcgc  caacctaca  taacttaaa  aggttgata  gtcaaattg  gtcttccat  780
actgcttcc  tcagatttg  tggggccct  aatgttgat  tgacagaat  ccagaccaa  840
ctggtgccc  accctcgca  ccacttccc  ctggccact  atgcccctg  catctctgc  900
gagaaagcc  accatgaac  gctttctgt  gcagagatc  ccaatgcct  ctttgagcc  960
gccaaccag  tggtgaaat  tgaccctcg  catggtaaa  acatggctt  ctgcctgct  1020
taccgtggt  atgtggtcc  caaagatgt  aatgctgcc  ttgccacca  caagaccaa  1080
cgtaccatc  agtttgtgg  ctggtgccc  actggcttc  aggttggca  taattacca  1140
cctcccact  tggtccctg  tggcgacct  gccaaggtc  agagagctg  gtgtatgct  1200
agcaacacc  cagccattg  tgaggcctg  gctcgcctg  atcacaagt  tgatctgat  1260
tatgccaag  gtgcctttg  gcactggta  gtgggtgag  gcatggagg  gggagagtt  1320
tctgaggcc  gtgaggaca  ggctgccct  gagaaggat  atgaggagg  tggtgtgga  1380
tctgtggag  gtgagggtg  ggaagaagg  gaggaatac  aaattaaat  tcacaaggt  1440
ctgctttca  agggatgtt  attctggtc  aacatagaa  gttgtgggc  gatcagtta  1500
tttgtatgt  gcaatgtgt  ctttcatac  gttactgac  ttaagtgtg  atgatttgt  1560
agagacccg  gccgtccac  tcactgatg  gttttaaat  aaatactcc  tgtctta  1617



<210> 9192
<211> 451
<212> PRT
<213> Rattus norvegicus
<308> P02551
<400> 9192

Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
  1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
             20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
         35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
     50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
 65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                 85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
             100                105                110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
         115                120                125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
     130                135                140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
 145                150                155                160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                 165                170                175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
             180                185                190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
         195                200                205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
     210                215                220
Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala 
 225                230                235                240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                 245                250                255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
             260                265                270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
         275                280                285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
     290                295                300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
 305                310                315                320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                 325                330                335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
             340                345                350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
         355                360                365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
     370                375                380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
 385                390                395                400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                 405                410                415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
             420                425                430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly 
         435                440                445
Glu Glu Tyr 
     450



<210> 9193
<211> 1657
<212> DNA
<213> Homo sapiens
<308> AF141347
<400> 9193

cctaagagt  gcgctgtaa  aagcaacaa  ctctcctct  cgtctccgc  atcagctcg  60
cagtcgcga  gcagcaacc  tgcgtgagt  catctccat  cacgttggc  aggctggtg  120
ccagattgg  aatgcctgc  gggagctct  ctgcctgga  cacggcatc  agcccgatg  180
ccagatgcc  agtgacaag  ccattgggg  aggagatga  tccttcaac  ccttcttca  240
tgagacggg  gctggcaag  atgtgcccc  ggcagtgtt  gtagacttg  aacccacag  300
cattgatga  gttcgcact  gcacctacc  ccagctctt  caccctgag  aacttatca  360
aggcaaaga  gatgctgcc  ataactatg  ccgagggca  tacaccatt  gcaaggaga  420
cattgacct  gtgttggac  gaattcgca  gctggccga  cagtgcacg  gtctccagg  480
cttcttggt  ttccacagc  ttggtgggg  aactggttc  gggttcacc  cgctgctca  540
ggaacgtct  tcagttgat  atggcaaga  gtccaagct  gagttctct  tttacccgg  600
gccccaggt  tccacagct  tagttgagc  ctacaactc  atcctcacc  cccacacca  660
cctggagca  tctgattgt  ccttcatgg  agacaatga  gccatctat  acatctgtc  720
tagaaacct  gatattgag  gtccaacct  tactaacct  aataggtta  taggtcaaa  780
tgtgtcctc  atcactgct  ccctgagat  tgatggagc  ctgaatgtt  acctgacag  840
attccagac  aacctggtg  cctatcccc  catccactt  cctctggcc  catatgccc  900
tgtcatctc  gctgagaaa  cctaccatg  acagctttc  gtagcagag  tcaccaatg  960
ttgctttga  ccagccaac  agatggtga  atgtgaccc  cgccatggt  aatacatgg  1020
ttgctgcct  ttgtaccgt  gtgacgtgg  tcccaaaga  gtcaatgct  ccattgcca  1080
catcaagac  aagcgtacc  tccagtttg  ggattggtg  cccactggc  tcaaggttg  1140
catcaacta  cagcctccc  ctgtggtgc  tggtggaga  ctggccaag  tacagagag  1200
tgtgtgcat  ctgagcaac  ccacagcca  tgctgaggc  tgggctcgc  tggaccaca  1260
gtttgacct  atgtatgcc  aacgtgcct  tgttcactg  tacgttggg  aggggatgg  1320
ggaaggtga  ttttcagag  cccgtgagg  catggctgc  cttgagaag  attatgagg  1380
ggttggtgt  gattctgtt  aaggagagg  tgaggaaga  ggagaggaa  actaaagtt  1440
aaacgtcac  aaggtgctg  ttttacagg  aagcttatt  tgttttaaa  attgaaaag  1500
tgtggtctg  tcagttaat  tgtatgtag  agtgtatgc  ctcatatac  attactgac  1560
tatgctcta  aacatgaat  ctttgttac  gacccaagc  gtccatttc  gtgatgggt  1620
ttgaataaa  tattccctg  cttaaaaaa  aaaaaaa  1657



<210> 9194
<211> 451
<212> PRT
<213> Homo sapiens
<308> P05209
<400> 9194

Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
  1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
             20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
         35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
     50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
 65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                 85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
             100                105                110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
         115                120                125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
     130                135                140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
 145                150                155                160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                 165                170                175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
             180                185                190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
         195                200                205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
     210                215                220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala 
 225                230                235                240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                 245                250                255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
             260                265                270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
         275                280                285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
     290                295                300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
 305                310                315                320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                 325                330                335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
             340                345                350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
         355                360                365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
     370                375                380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
 385                390                395                400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                 405                410                415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
             420                425                430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly 
         435                440                445
Glu Glu Tyr 
     450



<210> 9195
<211> 1136
<212> DNA
<213> Rattus norvegicus
<308> V01543
<400> 9195

tacaaagtg  acaagtatg  ccgtgcgtg  cctgatggg  ttgtcttga  gaataccca  60
tgcatccca  aaggcttgg  gagctacta  acggagcaa  actccagtg  ccgggagaa  120
ttttacact  tcataaatc  ctacaacct  gccaagcag  gcatcacgc  ctcagtgtc  180
ccgtggatg  cagttctgt  agaagagaa  ctgtcggaa  aggagaccg  agctgcaga  240
aagtcagct  agcaagcgg  gcaggttcc  tacaatgtg  cacttgaag  caacaaagg  300
actttgagg  acatttcat  aaatataat  accgataat  tagagatta  tcatttacg  360
tgcaattgc  tctgtttgc  aatgctgct  tgcaaataa  acttgctgc  gaccaccca  420
aggcataag  aaagtgcat  tcagcactg  ttagagagc  tgatgccac  gtccatgcc  480
aggagtcgc  atttagctc  ttcactggg  cgcactgga  actgtcaag  ggtaattcg  540
cctggctat  ccagggctc  ggccatcag  acagtgcat  tggtggttt  gttctcttt  600
atgcccctt  gctatttgc  gaccttacc  catacatag  gtgacccca  gctctgctg  660
ctgcagtgt  gatgcactg  taagcggcg  agaggaagg  aggtgtgca  cacgacaca  720
gcagccctg  cagggcagt  ctgggaggt  ctctttgct  tgtcccctg  gcagaacac  780
aggatgggg  ggggaggag  tggctctgg  ccagggggt  gccgagcct  tgctcctgt  840
ggtggtgtc  gctggtgat  tgctagata  gaagaaagc  cactggctc  ttcctttcc  900
gttatgata  atttgcacg  acagccctg  atgcaggtg  agttttggt  ttttgtttt  960
ttagccagt  ggcaaagtg  aatgtaatt  tgggtaagc  agggcttct  tagctttta  1020
tctgtgaac  gatgtgact  ctgtgctgt  ggaaggggg  aggacggct  gtggggggc  1080
gatgtggca  cttgaaaat  gaataagtc  acaatcttt  taagaaaag  accccg  1136



<210> 9196
<211> 119
<212> PRT
<213> Rattus norvegicus
<308> CAA24785
<400> 9196

Met Pro Gly Leu Arg Pro Ser Glu Gln Cys Ile Trp Trp Phe Arg Ser 
  1               5                  10                  15
Leu Leu Cys Pro Phe Ala Ile Cys Arg Pro Tyr Pro Ile His Arg Val 
             20                  25                  30
Thr Pro Arg Ser Ala Asp Cys Ser Val Asp Ala Leu Leu Ser Gly Ala 
         35                  40                  45
Glu Glu Gly Arg Cys Ala Pro Arg His Thr Gln Pro Cys Gln Gly Ser 
     50                  55                  60
Ser Gly Arg Phe Ser Leu Leu Cys Pro Leu Arg Arg Thr Arg Gly Trp 
 65                  70                  75                  80
Gly Gly Glu Glu Leu Ala Leu Gly Gln Gly Val Ala Glu Pro Val Leu 
                 85                  90                  95
Leu Trp Val Val Ser Ala Gly Asp Val Leu Asp Arg Lys Lys Ala His 
             100                105                110
Trp Leu Val Pro Phe Leu Leu 
         115



<210> 9197
<211> 1136
<212> DNA
<213> Rattus norvegicus
<308> V01543
<400> 9197

tacaaagtg  acaagtatg  ccgtgcgtg  cctgatggg  ttgtcttga  gaataccca  60
tgcatccca  aaggcttgg  gagctacta  acggagcaa  actccagtg  ccgggagaa  120
ttttacact  tcataaatc  ctacaacct  gccaagcag  gcatcacgc  ctcagtgtc  180
ccgtggatg  cagttctgt  agaagagaa  ctgtcggaa  aggagaccg  agctgcaga  240
aagtcagct  agcaagcgg  gcaggttcc  tacaatgtg  cacttgaag  caacaaagg  300
actttgagg  acatttcat  aaatataat  accgataat  tagagatta  tcatttacg  360
tgcaattgc  tctgtttgc  aatgctgct  tgcaaataa  acttgctgc  gaccaccca  420
aggcataag  aaagtgcat  tcagcactg  ttagagagc  tgatgccac  gtccatgcc  480
aggagtcgc  atttagctc  ttcactggg  cgcactgga  actgtcaag  ggtaattcg  540
cctggctat  ccagggctc  ggccatcag  acagtgcat  tggtggttt  gttctcttt  600
atgcccctt  gctatttgc  gaccttacc  catacatag  gtgacccca  gctctgctg  660
ctgcagtgt  gatgcactg  taagcggcg  agaggaagg  aggtgtgca  cacgacaca  720
gcagccctg  cagggcagt  ctgggaggt  ctctttgct  tgtcccctg  gcagaacac  780
aggatgggg  ggggaggag  tggctctgg  ccagggggt  gccgagcct  tgctcctgt  840
ggtggtgtc  gctggtgat  tgctagata  gaagaaagc  cactggctc  ttcctttcc  900
gttatgata  atttgcacg  acagccctg  atgcaggtg  agttttggt  ttttgtttt  960
ttagccagt  ggcaaagtg  aatgtaatt  tgggtaagc  agggcttct  tagctttta  1020
tctgtgaac  gatgtgact  ctgtgctgt  ggaaggggg  aggacggct  gtggggggc  1080
gatgtggca  cttgaaaat  gaataagtc  acaatcttt  taagaaaag  accccg  1136



<210> 9198
<211> 119
<212> PRT
<213> Rattus norvegicus
<308> NP_077042
<400> 9198

Met Pro Gly Leu Arg Pro Ser Glu Gln Cys Ile Trp Trp Phe Arg Ser 
  1               5                  10                  15
Leu Leu Cys Pro Phe Ala Ile Cys Arg Pro Tyr Pro Ile His Arg Val 
             20                  25                  30
Thr Pro Arg Ser Ala Asp Cys Ser Val Asp Ala Leu Leu Ser Gly Ala 
         35                  40                  45
Glu Glu Gly Arg Cys Ala Pro Arg His Thr Gln Pro Cys Gln Gly Ser 
     50                  55                  60
Ser Gly Arg Phe Ser Leu Leu Cys Pro Leu Arg Arg Thr Arg Gly Trp 
 65                  70                  75                  80
Gly Gly Glu Glu Leu Ala Leu Gly Gln Gly Val Ala Glu Pro Val Leu 
                 85                  90                  95
Leu Trp Val Val Ser Ala Gly Asp Val Leu Asp Arg Lys Lys Ala His 
             100                105                110
Trp Leu Val Pro Phe Leu Leu 
         115



<210> 9199
<211> 2216
<212> DNA
<213> Rattus norvegicus
<308> X01785
<400> 9199

gtcttactg  ggcccagag  aaggatggg  agtccggta  tcaggagac  tttctgcca  60
ctgtccacc  acagcctgc  ctgggccat  gcagcagta  cgctgagca  agctcaagt  120
gaagtggtg  cccaggatg  aagaaagct  ctgcacaca  ctgcatcct  acgctgttc  180
ctaaaaaca  cccaggaac  cttgattgt  acatggcag  aaaagaaag  cgtaggccc  240
gaaaacatg  tcacttaca  caaagccca  ggggttgtc  ttcagccca  ctacaaaga  300
aggataaac  tcactgagc  gggactctt  aacacaagc  tcaccttct  gaacacaac  360
ctggatgat  agggttgct  catgtgtct  ttcaacatg  ttggatctg  gaaggtctc  420
gggacagct  gccttactc  ctatgtaca  cccatagta  accttcact  caactattt  480
gaagaccac  taaacatca  gtgctctgc  actgcccgc  cagcccctg  catctcctg  540
aagggcact  ggtcaggaa  tgagaatag  actgagagt  actcccatt  aaatgggac  600
acatctgtc  ccagcatcc  ccgggtcaa  gaccccaaa  ctcaggttg  aaaggaagt  660
atctgccag  ttttatact  ggggaatgt  attgactac  agcagagtc  ggacaaagg  720
ttttggttt  cagtcccac  gctgctgag  attgtttct  tggtaattc  tctggtctt  780
atctccatc  tattatact  gaaacggca  cgaaatcag  agcggggtg  gtcatcaca  840
gggatgcaa  gaatgaaat  agagctcta  agaaattat  tcagaaccc  gaacgtgtt  900
ccctggtct  cttgaatct  atgttaaag  aaagcagga  ggaaaaggt  attctccat  960
ggacctaaa  aagagcaaa  gatgcagaa  gaagcctgt  agggatttg  ctttttgct  1020
ctgtcccgg  tcctcagta  ttacattcc  agaggaagt  gtgtgcctc  ggtctgttg  1080
aggacttga  ttttgtgga  caatgcagc  tcattgctg  tagaaaggc  ccagactta  1140
aatcaccag  gccaagccg  ctcgcagac  gactagggc  cccaccgga  ggacaaatc  1200
tagtcaact  acctcacag  gcttcctgg  ctttataca  agtagaaag  agtgggacc  1260
gaaaatttg  catgtctga  atctgatgg  attttagga  gaaaactga  gagcgatca  1320
aagaagaag  gagaacaca  aagggtcaa  gagcttcgg  gagtacctt  tgcctttct  1380
ttggggtcc  acctctggt  ttgttctta  gtccaccag  ttgtttccc  gttgtttga  1440
tatctaatt  actacctgc  actgttccg  tgattgttg  ccttgctaa  atccctgat  1500
cccctgccg  tctctatgt  cttctatga  ggttactat  atgaaaata  agaagaatt  1560
agtgtgaag  aacattggc  accgtaatg  gtccattta  cttattttt  tagcacgta  1620
gcaaatacc  ttagtctta  caagtagtt  acatcttta  aaaagcatg  tttccctgt  1680
catttggcc  aggatatca  ccactttga  gccattctg  atcctgtct  gtgtaacga  1740
aatatatta  gaaaacaga  gtgttaaga  tttcctgta  agcagtcag  tgtatattc  1800
ctctctctc  ctctctctc  ctctctctc  ctctctctc  ctctctcaa  ttctttttc  1860
gtgacttta  ttttcacaa  gagaaggca  ctctggaat  caatcgctt  gttctgaag  1920
catttgtgg  catcttaac  ctttgacag  actagtgac  ttgttttct  tatcttttg  1980
ttcatctgt  tctgtagag  gacctagga  ttcaagtgt  agttgtttt  attgtcaaa  2040
tcgatattt  tatacttgg  atgcttttc  tgtgttatt  aattccgta  aattttcct  2100
tatttgtat  aaaatactg  gcaattaaa  gtgtcaact  aatagttga  gtgtgacat  2160
cccttgaga  atatagaaa  aaagaataa  acttggatt  ttttttctc  gtattc  2216



<210> 9200
<211> 278
<212> PRT
<213> Rattus norvegicus
<308> P04218
<400> 9200

Met Gly Ser Pro Val Phe Arg Arg Pro Phe Cys His Leu Ser Thr Tyr 
  1               5                  10                  15
Ser Leu Leu Trp Ala Ile Ala Ala Val Ala Leu Ser Thr Ala Gln Val 
             20                  25                  30
Glu Val Val Thr Gln Asp Glu Arg Lys Leu Leu His Thr Thr Ala Ser 
         35                  40                  45
Leu Arg Cys Ser Leu Lys Thr Thr Gln Glu Pro Leu Ile Val Thr Trp 
     50                  55                  60
Gln Lys Lys Lys Ala Val Gly Pro Glu Asn Met Val Thr Tyr Ser Lys 
 65                  70                  75                  80
Ala His Gly Val Val Ile Gln Pro Thr Tyr Lys Asp Arg Ile Asn Ile 
                 85                  90                  95
Thr Glu Leu Gly Leu Leu Asn Thr Ser Ile Thr Phe Trp Asn Thr Thr 
             100                105                110
Leu Asp Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Met Phe Gly Ser 
         115                120                125
Gly Lys Val Ser Gly Thr Ala Cys Leu Thr Leu Tyr Val Gln Pro Ile 
     130                135                140
Val His Leu His Tyr Asn Tyr Phe Glu Asp His Leu Asn Ile Thr Cys 
 145                150                155                160
Ser Ala Thr Ala Arg Pro Ala Pro Ala Ile Ser Trp Lys Gly Thr Gly 
                 165                170                175
Ser Gly Ile Glu Asn Ser Thr Glu Ser His Ser His Ser Asn Gly Thr 
             180                185                190
Thr Ser Val Thr Ser Ile Leu Arg Val Lys Asp Pro Lys Thr Gln Val 
         195                200                205
Gly Lys Glu Val Ile Cys Gln Val Leu Tyr Leu Gly Asn Val Ile Asp 
     210                215                220
Tyr Lys Gln Ser Leu Asp Lys Gly Phe Trp Phe Ser Val Pro Leu Leu 
 225                230                235                240
Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu 
                 245                250                255
Leu Tyr Trp Lys Arg His Arg Asn Gln Glu Arg Gly Glu Ser Ser Gln 
             260                265                270
Gly Met Gln Arg Met Lys 
         275



<210> 9201
<211> 210
<212> DNA
<213> Homo sapiens
<308> X05323
<400> 9201

ttccttgga  ttgtccaaa  ccaaacccc  atttctgta  tttgctttc  gtcttcagg  60
gatcaggat  cccttctct  atctgtcta  ctacagcct  gtttgggtc  tggcagcag  120
ggtgctgtg  acagcacaa  gtaaagaaa  tcaattccc  tgcttggag  ccagcaaac  180
caatttctg  ggtgaagac  tttagccaga  210



<210> 9202
<211> 274
<212> PRT
<213> Homo sapiens
<308> CAA28943
<400> 9202

Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr Ser Leu Val Trp 
  1               5                  10                  15
Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val Gln Val Val Thr 
             20                  25                  30
Gln Asp Glu Arg Glu Gln Leu Tyr Thr Thr Ala Ser Leu Lys Cys Ser 
         35                  40                  45
Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp Gln Lys Lys Lys 
     50                  55                  60
Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu Asn His Gly Val 
 65                  70                  75                  80
Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile Thr Gln Leu Gly 
                 85                  90                  95
Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr Leu Glu Asp Glu 
             100                105                110
Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe Gly Lys Ile Ser 
         115                120                125
Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile Val Ser Leu His 
     130                135                140
Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys Ser Ala Thr Ala 
 145                150                155                160
Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg Ser Gly Ile Glu 
                 165                170                175
Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr Thr Ser Val Thr 
             180                185                190
Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val Gly Lys Glu Val 
         195                200                205
Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp Phe Lys Gln Thr 
     210                215                220
Val Asn Lys Gly Tyr Trp Phe Ser Val Pro Leu Leu Leu Ser Ile Val 
 225                230                235                240
Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu Leu Tyr Trp Lys 
                 245                250                255
Arg His Arg Asn Gln Asp Arg Gly Glu Leu Ser Gln Gly Val Gln Lys 
             260                265                270
Met Thr 
         275



<210> 9203
<211> 890
<212> DNA
<213> Rattus norvegicus
<308> X02412
<400> 9203

gctgaagct  acgtagcat  tctgaacag  cgcatccag  tggttgagg  ggagttgga  60
cgggctcag  agcggctgg  cacagctct  cagaagctg  aggaggctg  gaaggctgc  120
gatgagagt  agagaggca  gaaagtcat  gaaagccga  cccaaaaag  tgaagaaaa  180
atggagatt  aggagatcc  gctgaaaga  gccaagcac  ttgctgaag  tgctgaccg  240
aagtatgaa  aggtggccc  taagctggt  atcatcgag  gtgatctgg  gcgtgcgga  300
gagagggct  agctctcgg  aggcaaatg  gcggagctt  aagaagagt  gaaaacggt  360
acgaacaac  tgaagtcac  ggaggctca  gctgagaag  actctcaga  agaagacaa  420
tatgaagag  agatcaagg  tctctctga  aagctgaag  aggctgaga  ccgggctga  480
tttgcagag  gatcagtaa  caaattgga  aaaagcatt  atgacttag  agacgagct  540
tatgctcag  aactgaagt  caaggccat  agcgaggag  tggaccacg  tctcaacga  600
atgacttcc  tataagttc  gcttctctc  tcccaagac  ccttcattc  agccggaat  660
tcccacctc  ctgagctct  catctgtct  ctctccagc  gacccaggt  tctttctag  720
gcccaccca  cctagggcc  gcacagacc  tgctttcta  tgtacagag  tgatcctcc  780
agtgtaaaa  aaacactgt  cgctagtcc  gtttgctat  cctctgctc  ttatttatt  840
acatttttg  ctcagcgct  aataaaact  cagttctgc  ttgtgatcta  890



<210> 9204
<211> 284
<212> PRT
<213> Rattus norvegicus
<308> Q63582
<400> 9204

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
  1               5                  10                  15
Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
             20                  25                  30
Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
         35                  40                  45
Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
     50                  55                  60
Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
 65                  70                  75                  80
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                 85                  90                  95
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
             100                105                110
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
         115                120                125
Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
     130                135                140
Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
 145                150                155                160
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                 165                170                175
Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
             180                185                190
Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
         195                200                205
Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu 
     210                215                220
Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
 225                230                235                240
Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                 245                250                255
Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
             260                265                270
Glu Leu Asp His Ala Leu Lys Asp Met Thr Ser Ile 
         275                280



<210> 9205
<211> 2301
<212> DNA
<213> Homo sapiens
<308> X03541
<400> 9205

gtcgaccgg  gggcaggag  agcaggagg  gcaggagca  gaggagcag  aggagcagg  60
ggagcagga  gagcaggag  agcaggaac  ggaggagga  gaggaggag  aggaggagc  120
ggaagagca  gaggaggag  agcaggagc  ggaggagca  gagggagag  aggctgcaa  180
gccgagcgg  ggaggcagg  accggagcg  gagcagtag  tgggtgggc  ccatggctg  240
gatcaccac  atcgaggcg  tgaagcgca  gatccaggt  ctgcagcag  aggcagatg  300
tgcagagga  cgagctgag  gcctccagc  agaagttga  ggagaaagg  gggcccggg  360
acaggctga  gctgaggtg  cctccttga  ccgtaggat  cagctggtt  aagaagagc  420
ggaccgtgc  caggagcgc  tggccactg  cctgcaaaa  ctggaagaa  ctgaaaaag  480
tgctgatga  agtgagaga  gtatgaagg  tattgaaaa  cgggcctta  aagatgaag  540
aaagatgga  ctccaggaa  tccaactcg  agaagctaa  cacattgca  aagaggcag  600
taggaagta  gaagaggtg  ctcgtaagt  ggtgatcat  gaaggagac  tggaacgca  660
agaggaacg  gctgagctg  cagagtcgc  ttgccgaga  atggatgag  agattagac  720
gatggacca  aacctgaag  gtctgagtg  tgccgaaga  aagtactct  aaaaagaag  780
taaatatga  gaagaaatc  agattctta  tgataaact  aaggaggca  agacccgtg  840
tgagtttgc  gagagatcg  tagccaagc  ggaaaagac  attgatgac  tggaagaca  900
taacagcac  tctggagac  cggtggaga  gaaggacga  acacctttt  gggtctcgg  960
ggctgtggg  ctggccgtc  ttgcctgcc  cttcctttc  acgctgctc  ttgtgctca  1020
caaatgtgg  cggagaaac  agtttggga  caaccgccc  gctgtgctg  ctccagagg  1080
tgggctggc  atgtccctg  atttcatga  attgggtgg  agctccctg  cccccaccg  1140
gggcaaagg  tctgggctc  aaggccaca  catcgagaa  ccacaatac  tcagtgatg  1200
ctgtgttca  cacatcaag  gccgggaca  cgtgctcaa  tgggagctg  gggagggcg  1260
ctttgggaa  gtcttcctt  ctgagtgcc  caacctcct  cctgagcag  acaagatgc  1320
ggtggctgt  aaggcactg  aggaggcgt  cgagagtgc  cggcaggac  tccaacgtg  1380
ggctgagct  ctcaccatg  tgcagcacc  gcacatcgt  cgcttcttc  gcgtctgca  1440
cgagggccg  cccctgctc  tggtcttcg  gtatatgcg  cacggggac  tcaaccgct  1500
cctccgatc  catggaccc  atgccaagc  gctggctgg  ggggaggat  tggctccag  1560
ccccctggg  ctggggcag  tgctggccg  ggctagcca  gtcgctgcg  ggatggtgt  1620
cctggcggg  ctgcatttt  tgcaccggg  cctggccac  cgcaactgt  tagtgggcc  1680
gggactggt  gtcaagatt  gtgattttg  catgagcag  gatatctac  gcaccgact  1740
ttaccgtgt  ggaggccgc  ccatgctgc  cattcgctg  atgccgccc  agagcatcc  1800
gtaccgtaa  ttcaccacc  agagcgacg  gtggagctt  ggcgtggtg  tctgggaga  1860
cttcaccta  ggcaagcag  cctggtacc  gctctccaa  acggaggca  tcgactgca  1920
cacgcaggg  cgtgagttg  agcggccac  tgcctgccc  ccagaggtc  acgccatca  1980
gcggggctg  tggcagcgg  agcccagca  cgccacagc  tcaaggatg  gcacgcccg  2040
ctgcaagcc  tggcctagg  acctcctgt  tacctggat  tcctgggct  gggggccgg  2100
ccaggggct  ggagtggtt  gccggaata  tggggcctg  cctcagcat  ccccatagc  2160
cccagcagc  ccagggtga  ctcgaagta  ctaattcgc  ctcagcatg  gggaaggga  2220
aggtggggg  tgggagtag  ggatgttcc  gcttctcta  gcaaggtcc  gtcgtagca  2280
ttatattta  tatgggaat  c  2301



<210> 9206
<211> 796
<212> PRT
<213> Homo sapiens
<308> P04629
<400> 9206

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
  1               5                  10                  15
Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
             20                  25                  30
Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
         35                  40                  45
Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
     50                  55                  60
Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
 65                  70                  75                  80
His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                 85                  90                  95
Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
             100                105                110
Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
         115                120                125
Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
     130                135                140
Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
 145                150                155                160
Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                 165                170                175
Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
             180                185                190
Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
         195                200                205
Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
     210                215                220
Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
 225                230                235                240
Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                 245                250                255
Asp Leu Asn Arg Lys Asn Leu Thr Cys Trp Ala Glu Asn Asp Val Gly 
             260                265                270
Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
         275                280                285
Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
     290                295                300
Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
 305                310                315                320
Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                 325                330                335
Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
             340                345                350
His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
         355                360                365
Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
     370                375                380
Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
 385                390                395                400
Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe 
                 405                410                415
Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu 
             420                425                430
Ser Thr Leu Leu Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe 
         435                440                445
Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met 
     450                455                460
Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu 
 465                470                475                480
Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr 
                 485                490                495
Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu 
             500                505                510
Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu 
         515                520                525
Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys 
     530                535                540
Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu 
 545                550                555                560
Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe 
                 565                570                575
Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met 
             580                585                590
Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala 
         595                600                605
Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu 
     610                615                620
Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr 
 625                630                635                640
Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys 
                 645                650                655
Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser 
             660                665                670
Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met 
         675                680                685
Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe 
     690                695                700
Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile 
 705                710                715                720
Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala 
                 725                730                735
Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys 
             740                745                750
Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro 
         755                760                765
Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu 
     770                775                780
Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
 785                790                795



<210> 9207
<211> 1771
<212> DNA
<213> Rattus norvegicus
<308> X02601
<400> 9207

aaggaggca  caaagaacc  gctgagagc  gtgcagaac  gtgggaagc  agtggaaat  60
aaagggctc  cagtcctgc  gtggctgtg  acggctgtg  gctcatcct  cccattgca  120
ggcagtgaa  aagatgctg  catggaggt  ctgcagaaa  acctagaaa  ctactatgg  180
cttgaaaag  atgtgaagc  gtttactaa  aaaaaggac  gtagccctg  tgtcaaaaa  240
attcaagaa  tgcagaagt  ccttgggct  aagatgaca  ggaagctgg  ctcgaacac  300
atggagctg  tgcacaagc  ccggtgtgg  gttcccgac  tcggtggct  cagtacctt  360
ccaggttca  ccaaatgga  gaaaaacca  atctcctac  ggattgtga  ttatacact  420
gatttacca  gagagagtg  ggattctgc  attgagaga  ctttgaagg  ctgggagga  480
gtgacccca  tcacattct  caggatctc  gaaggagag  ctgacataa  gatctcctt  540
gcagttgaa  aacatggag  ctttatccc  tttgatggg  ctggaatgg  cttggctca  600
gcctatgcc  ctggaccag  gaccaatgg  gatgctcac  ttgatgatg  tgaacgatg  660
acagatgat  tcacaggta  caacctatt  ctggttgct  ctcatgaac  tggccactc  720
ctgggtctc  ttcactcag  caatgctga  gctttgatg  acccagtct  caagtcctc  780
acagacctg  cccgtttcc  tctctctca  gatgatgta  atggtattc  atccctcta  840
ggacctccc  cagaatccc  tgatgtcct  gtggtaccc  ccaaatcta  ctctctgga  900
cctgagacc  taccaatgt  tagctctgc  ttgtccttc  atgcagtca  caccctgcg  960
ggagaagtc  tgttcttta  agacaggca  ttttggcga  aatctctca  gacccctga  1020
cctggcttt  atttgatct  ttcattttg  ccgtctctt  catccaaca  ggatgctgc  1080
tatgaagtt  ctaacagag  cactgtttt  attcttaaa  gaaatcaga  ctgggctat  1140
cgaggtcat  aagagctag  aggttatcc  aaaagcatt  acactctgg  cctccctga  1200
accgtccag  agatcgatg  agccatttc  ttaaaggac  aaaagaaga  gtacttctt  1260
gtagaggac  aattctgga  atttgatga  aagaaacaa  ccatggatc  agaatttcc  1320
aggaaaata  ctgagaact  tccaggcat  ggcacaaag  tggatgctg  ctttgaagc  1380
tttgggttt  tttacttct  cagcggatc  tcacagttg  agtttgatc  aaatgcagg  1440
aaagtgacc  acatattga  gagcaacag  tggtttaat  gttaagaag  tccatggaa  1500
gcgtcgtgt  tttcagctg  ccctgatag  tcttcctct  aaacttggc  cactgaagt  1560
gtttcctta  tctagcatg  gctatggca  agcaaaatg  gagctacat  tggcaccag  1620
caacctcaa  ttgtcgaag  acattcaga  gcactgctt  tcttatact  tgtcaaagg  1680
agaggagaa  acacactcc  gggctacag  caagtaact  tctctgtgt  gatggtttg  1740
tttatttaa  aaaatggtg  gtcatttat  t  1771



<210> 9208
<211> 475
<212> PRT
<213> Rattus norvegicus
<308> P03957
<400> 9208

Met Lys Gly Leu Pro Val Leu Leu Trp Leu Cys Thr Ala Val Cys Ser 
  1               5                  10                  15
Ser Tyr Pro Leu His Gly Ser Glu Glu Asp Ala Gly Met Glu Val Leu 
             20                  25                  30
Gln Lys Tyr Leu Glu Asn Tyr Tyr Gly Leu Glu Lys Asp Val Lys Gln 
         35                  40                  45
Phe Thr Lys Lys Lys Asp Ser Ser Pro Val Val Lys Lys Ile Gln Glu 
     50                  55                  60
Met Gln Lys Phe Leu Gly Leu Lys Met Thr Gly Lys Leu Asp Ser Asn 
 65                  70                  75                  80
Thr Met Glu Leu Met His Lys Pro Arg Cys Gly Val Pro Asp Val Gly 
                 85                  90                  95
Gly Phe Ser Thr Phe Pro Gly Ser Pro Lys Trp Arg Lys Asn His Ile 
             100                105                110
Ser Tyr Arg Ile Val Asn Tyr Thr Leu Asp Leu Pro Arg Glu Ser Val 
         115                120                125
Asp Ser Ala Ile Glu Arg Ala Leu Lys Val Trp Glu Glu Val Thr Pro 
     130                135                140
Leu Thr Phe Ser Arg Ile Ser Glu Gly Glu Ala Asp Ile Met Ile Ser 
 145                150                155                160
Phe Ala Val Glu Glu His Gly Asp Phe Ile Pro Phe Asp Gly Pro Gly 
                 165                170                175
Met Val Leu Ala His Ala Tyr Ala Pro Gly Pro Gly Thr Asn Gly Asp 
             180                185                190
Ala His Phe Asp Asp Asp Glu Arg Trp Thr Asp Asp Val Thr Gly Thr 
         195                200                205
Asn Leu Phe Leu Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu 
     210                215                220
Phe His Ser Ala Asn Ala Glu Ala Leu Met Tyr Pro Val Tyr Lys Ser 
 225                230                235                240
Ser Thr Asp Leu Ala Arg Phe His Leu Ser Gln Asp Asp Val Asp Gly 
                 245                250                255
Ile Gln Ser Leu Tyr Gly Pro Pro Thr Glu Ser Pro Asp Val Leu Val 
             260                265                270
Val Pro Thr Lys Ser Asn Ser Leu Asp Pro Glu Thr Leu Pro Met Cys 
         275                280                285
Ser Ser Ala Leu Ser Phe Asp Ala Val Ser Thr Leu Arg Gly Glu Val 
     290                295                300
Leu Phe Phe Lys Asp Arg His Phe Trp Arg Lys Ser Leu Arg Thr Pro 
 305                310                315                320
Glu Pro Gly Phe Tyr Leu Ile Ser Ser Phe Trp Pro Ser Leu Pro Ser 
                 325                330                335
Asn Met Asp Ala Ala Tyr Glu Val Thr Asn Arg Asp Thr Val Phe Ile 
             340                345                350
Leu Lys Gly Asn Gln Ile Trp Ala Ile Arg Gly His Glu Glu Leu Ala 
         355                360                365
Gly Tyr Pro Lys Ser Ile His Thr Leu Gly Leu Pro Glu Thr Val Gln 
     370                375                380
Lys Ile Asp Ala Ala Ile Ser Leu Lys Asp Gln Lys Lys Thr Tyr Phe 
 385                390                395                400
Phe Val Glu Asp Lys Phe Trp Arg Phe Asp Glu Lys Lys Gln Ser Met 
                 405                410                415
Asp Pro Glu Phe Pro Arg Lys Ile Ala Glu Asn Phe Pro Gly Ile Gly 
             420                425                430
Thr Lys Val Asp Ala Val Phe Glu Ala Phe Gly Phe Leu Tyr Phe Phe 
         435                440                445
Ser Gly Ser Ser Gln Leu Glu Phe Asp Pro Asn Ala Gly Lys Val Thr 
     450                455                460
His Ile Leu Lys Ser Asn Ser Trp Phe Asn Cys 
 465                470                475



<210> 9209
<211> 1434
<212> DNA
<213> Homo sapiens
<308> J03209
<400> 9209

atgaagagt  ttccaatcc  actgttgct  tgcgtggca  tttgctcag  ctatccatt  60
gatggagct  caaggggtg  ggacaccag  atgaacctt  ttcagaaat  tctagaaaa  120
tactacgac  tcgaaaaag  tgtgaaaca  tttgttagg  gaaaggaca  tggtcctgt  180
gttaaaaaa  tccgagaaa  gcagaagtt  cttggattg  aggtgacgg  gaagctgga  240
tccgacact  tggaggtga  gcgcaagcc  aggtgtgga  ttcctgacg  tggtcactt  300
agaaccttt  ctggcatcc  gaagtggag  aaaacccac  ttacataca  gattgtgaa  360
tatacacca  atttgccaa  agatgctgt  gattctgct  ttgagaaag  tctgaaagt  420
tgggaagag  tgactccac  cacattctc  aggctgtat  aaggagagg  tgatataat  480
atctctttt  cagttagag  acatggaga  ttttaccct  ttgatggac  tggaaatgt  540
ttggcccat  cctatgccc  tgggccagg  attaatgga  atgcccact  tgatgatga  600
gaacaatgg  caaaggata  aacagggac  aatttattt  tcgttgctg  tcatgaaat  660
ggccactcc  tgggtctct  tcactcagc  aacactgaa  ctttgatgt  cccactcta  720
cactcactc  cagacctga  tcggttccg  ctgtctcaa  atgatataa  tggcattca  780
tccctctat  gacctcccc  tgactcccc  gagaccccc  tggtaccca  ggaacctgt  840
cctccagaa  ctgggacgc  agccaactg  gatcctgct  tgtcctttg  tgctgtcag  900
actctgagg  gagaaatcc  gatctttaa  gacaggcac  tttggcgca  atccctcag  960
aagcttgaa  ctgaattgc  tttgatctc  tcattttgg  catctcttc  ttcaggcgt  1020
gatgccgca  atgaagtta  tagcaagga  ctcgttttc  tttttaaag  aaatcaatt  1080
tgggccatc  gaggaaatg  ggtacgagc  ggataccca  gaggcatcc  caccctagg  1140
ttccctcca  ccgtgagga  aatcgatgc  gccatttcg  ataaggaaa  gaacaaaac  1200
tatttcttt  tagaggaca  atactggag  tttgatgag  agagaaatt  catggagcc  1260
ggctttccc  agcaaatag  tgaagactt  ccagggatt  actcaaaga  tgatgctgt  1320
tttgaagaa  ttgggttct  ttatttctt  actggatct  cacagttgg  gtttgaccc  1380
aatgcaaag  aagtgacac  cactttgaa  agtaacagc  ggcttaatt  ttga  1434



<210> 9210
<211> 477
<212> PRT
<213> Homo sapiens
<308> P08254
<400> 9210

Met Lys Ser Leu Pro Ile Leu Leu Leu Leu Cys Val Ala Val Cys Ser 
  1               5                  10                  15
Ala Tyr Pro Leu Asp Gly Ala Ala Arg Gly Glu Asp Thr Ser Met Asn 
             20                  25                  30
Leu Val Gln Lys Tyr Leu Glu Asn Tyr Tyr Asp Leu Lys Lys Asp Val 
         35                  40                  45
Lys Gln Phe Val Arg Arg Lys Asp Ser Gly Pro Val Val Lys Lys Ile 
     50                  55                  60
Arg Glu Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp 
 65                  70                  75                  80
Ser Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp 
                 85                  90                  95
Val Gly His Phe Arg Thr Phe Pro Gly Ile Pro Lys Trp Arg Lys Thr 
             100                105                110
His Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Lys Asp 
         115                120                125
Ala Val Asp Ser Ala Val Glu Lys Ala Leu Lys Val Trp Glu Glu Val 
     130                135                140
Thr Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met 
 145                150                155                160
Ile Ser Phe Ala Val Arg Glu His Gly Asp Phe Tyr Pro Phe Asp Gly 
                 165                170                175
Pro Gly Asn Val Leu Ala His Ala Tyr Ala Pro Gly Pro Gly Ile Asn 
             180                185                190
Gly Asp Ala His Phe Asp Asp Asp Glu Gln Trp Thr Lys Asp Thr Thr 
         195                200                205
Gly Thr Asn Leu Phe Leu Val Ala Ala His Glu Ile Gly His Ser Leu 
     210                215                220
Gly Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr 
 225                230                235                240
His Ser Leu Thr Asp Leu Thr Arg Phe Arg Leu Ser Gln Asp Asp Ile 
                 245                250                255
Asn Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Asp Ser Pro Glu Thr 
             260                265                270
Pro Leu Val Pro Thr Glu Pro Val Pro Pro Glu Pro Gly Thr Pro Ala 
         275                280                285
Asn Cys Asp Pro Ala Leu Ser Phe Asp Ala Val Ser Thr Leu Arg Gly 
     290                295                300
Glu Ile Leu Ile Phe Lys Asp Arg His Phe Trp Arg Lys Ser Leu Arg 
 305                310                315                320
Lys Leu Glu Pro Glu Leu His Leu Ile Ser Ser Phe Trp Pro Ser Leu 
                 325                330                335
Pro Ser Gly Val Asp Ala Ala Tyr Glu Val Thr Ser Lys Asp Leu Val 
             340                345                350
Phe Ile Phe Lys Gly Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val 
         355                360                365
Arg Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr 
     370                375                380
Val Arg Lys Ile Asp Ala Ala Ile Ser Asp Lys Glu Lys Asn Lys Thr 
 385                390                395                400
Tyr Phe Phe Val Glu Asp Lys Tyr Trp Arg Phe Asp Glu Lys Arg Asn 
                 405                410                415
Ser Met Glu Pro Gly Phe Pro Lys Gln Ile Ala Glu Asp Phe Pro Gly 
             420                425                430
Ile Asp Ser Lys Ile Asp Ala Val Phe Glu Glu Phe Gly Phe Phe Tyr 
         435                440                445
Phe Phe Thr Gly Ser Ser Gln Leu Glu Phe Asp Pro Asn Ala Lys Lys 
     450                455                460
Val Thr His Thr Leu Lys Ser Asn Ser Trp Leu Asn Cys 
 465                470                475



<210> 9211
<211> 735
<212> DNA
<213> Rattus norvegicus
<308> X02904
<400> 9211

acgcagctt  gagtccaca  ctctgtcta  gcagcagct  tgccgccgt  caccattgt  60
tacttccca  ttcgagggc  ctgtgaggc  acgcgcatg  tgctggctg  ccagggcca  120
agctggaag  aggaggtgg  taccataga  gtctggctt  aaggctcgc  caagtccac  180
tgtctgtat  ggcagctcc  caagtttga  gatggagac  tcacccttt  ccaatctaa  240
gccatcttg  ggcacctgg  tcgctcttt  gggctttat  ggaaagacc  gaaggaggc  300
gccttggtg  atatggtga  tgatggggt  gaggacctt  gatgcaaat  tggtaccct  360
atctacact  actatgaga  tggtaagga  gactatgtg  aggccctgc  tgggcatct  420
aaacctttt  agaccctgc  gtcccagaa  cagggaggc  aagctttca  tgtgggtaa  480
cagatttcc  ttgcagatt  caacttgct  gacctgctg  tggtccacc  agtcctggc  540
cctggctgc  tggacaact  ccccctgct  tctgcctat  tggctcgcc  cagtgcccg  600
cccaagatc  aggcctttc  gtcctcccc  gaccatttg  accgtccca  caacggcaa  660
ggtaaacag  agtggacga  gggacagga  ctccttgtc  cccttttcc  agactaata  720
agtttgtaa  gcaga  735



<210> 9212
<211> 209
<212> PRT
<213> Rattus norvegicus
<308> P04906
<400> 9212

Pro Pro Tyr Thr Ile Val Tyr Phe Pro Val Arg Gly Arg Cys Glu Ala 
  1               5                  10                  15
Thr Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu Val 
             20                  25                  30
Val Thr Ile Asp Val Trp Leu Gln Gly Ser Leu Lys Ser Thr Cys Leu 
         35                  40                  45
Tyr Gly Gln Leu Pro Lys Phe Glu Asp Gly Asp Leu Thr Leu Tyr Gln 
     50                  55                  60
Ser Asn Ala Ile Leu Arg His Leu Gly Arg Ser Leu Gly Leu Tyr Gly 
 65                  70                  75                  80
Lys Asp Gln Lys Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly Val 
                 85                  90                  95
Glu Asp Leu Arg Cys Lys Tyr Gly Thr Leu Ile Tyr Thr Asn Tyr Glu 
             100                105                110
Asn Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly His Leu Lys Pro 
         115                120                125
Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Ala Phe Ile Val 
     130                135                140
Gly Asn Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu Leu 
 145                150                155                160
Val His Gln Val Leu Ala Pro Gly Cys Leu Asp Asn Phe Pro Leu Leu 
                 165                170                175
Ser Ala Tyr Val Ala Arg Leu Ser Ala Arg Pro Lys Ile Lys Ala Phe 
             180                185                190
Leu Ser Ser Pro Asp His Leu Asn Arg Pro Ile Asn Gly Asn Gly Lys 
         195                200                205
Gln 
     210



<210> 9213
<211> 719
<212> DNA
<213> Homo sapiens
<308> U30897
<400> 9213

gtcttcgcc  ccatgccgc  ctacaccgt  gtctatttc  cagttcgag  ccgctgcgc  60
gccctgcgc  tgctgctgg  agatcaggg  cagagctgg  aggaggagg  ggtgaccgt  120
gagacgtgg  aggagggct  actcaaagc  tcctgccta  acgggcagc  ccccaagtt  180
caggacgga  acctcaccc  gtaccagtc  aataccatc  tgcgtcacc  gggccgcac  240
cttgggctc  atgggaagg  ccagcagga  gcagccctg  tggacatgg  gaatgacgg  300
gtggaggac  tccgctgca  atacgtctc  ctcatctac  ccaactatg  ggcgggcaa  360
gatgactat  tgaaggcac  gcccgggca  ctgaagcct  ttgagaccc  gctgtccca  420
aaccaggga  gcaagacct  cattgtggg  gaccagatc  ccttcgctg  ctacaacct  480
ctggacttg  tgctgatcc  tgaggtcct  gcccctggc  gcctggatg  gttccccct  540
ctctcagca  atgtggggc  cctcagtgc  cggcccaag  tcaaggcct  cctggcctc  600
cctgagtac  tgaacctcc  catcaatgg  aacgggaaa  agtgagggt  ggggggact  660
tgagcggga  gcagagttt  ccttccttt  tccaggacc  ataaaattt  taagagagc  719



<210> 9214
<211> 209
<212> PRT
<213> Homo sapiens
<308> P09211
<400> 9214

Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Gly Arg Cys Ala Ala 
  1               5                  10                  15
Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu Val 
             20                  25                  30
Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys Leu 
         35                  40                  45
Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr Gln 
     50                  55                  60
Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr Gly 
 65                  70                  75                  80
Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly Val 
                 85                  90                  95
Glu Asp Leu Arg Cys Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr Glu 
             100                105                110
Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys Pro 
         115                120                125
Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile Val 
     130                135                140
Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu Leu 
 145                150                155                160
Ile His Glu Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu Leu 
                 165                170                175
Ser Ala Tyr Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala Phe 
             180                185                190
Leu Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly Lys 
         195                200                205
Gln 
     210



<210> 9215
<211> 3955
<212> DNA
<213> Rattus norvegicus
<308> X03362
<400> 9215

ccgggccgg  gccgcaatg  tcatcatgg  gctggcggc  tggtgccgc  gggggttcc  60
cctcgccct  ctgcccccc  gaatcgcgg  cacccaagt  tgtaccggc  cagacatga  120
gttgcggct  cctgccagt  ctgagaccc  cctggacat  ctccgccac  tgtaccagg  180
ctgtcaggt  gtgcagggc  acttggagc  tacctacgt  cctgccaat  ccagcctct  240
attcctgca  gacatccag  aagttcagg  ttacatgct  atcgctcac  accaggtga  300
gcgcgtccc  ctgcaaagg  tgcgcatcg  gagagggac  cagctcttt  aggacaagt  360
tgccctggc  gtgctagac  accgagatc  tcaggacaa  gtcgccgcc  ccaccccag  420
cagaacccc  gaggggctg  gggagctgc  gcttcgaag  ctcacagag  tcctgaagg  480
aggagtttt  atccgtggg  accctcagc  ctgctacca  gacatggtt  tgtggaagg  540
cgtcttccg  aagaataac  aactggctc  tgtcgatat  gacaccaat  gttcccggg  600
ctgtccacc  tgtgccccc  cctgcaaag  caatcactg  tggggtgag  gtccggaag  660
ctgtcagat  ttgactggc  ccatctgta  cagtggttg  gcccggtgc  agggccggc  720
gcccactga  tgctgccat  agcagtgtg  cgcaggctg  acgggcccc  agcattctg  780
ctgcctggc  tgcctccac  tcaatcata  tggtatctg  gagctgcac  gcccagccc  840
cgtcaccta  aacacagac  cctttgagt  catgcacaa  cctgagggt  gctacacct  900
tggtgccag  tgcgtgacc  cctgcccct  caactacct  tctacggaa  tgggatcct  960
cactctggt  tgtcccccg  ataaccaag  ggtcacagc  gaggacgga  cacagcgtt  1020
tgagaaatg  agcaagccc  gtgctcgag  gtgctatgg  ctgggcatg  agcaccttc  1080
aggggcgag  gccatcacc  gtgacaatg  ccaggagtt  gatggctgc  agaagatct  1140
tgggagcct  gcatttttg  cggagagct  tgatgggga  ccctcctcc  gcattgctc  1200
gctgaggcc  gagcagctc  aagtgttcg  aaccctgga  gagatcaca  gttacctgt  1260
catctcagc  tggccagac  gtctccgtg  cctcagtgt  ttccagaac  ttcgaatca  1320
tcggggacg  attctccac  atggcgcgt  ctcattgac  ctgcaaggc  tggggatcc  1380
ctcgctggg  ctgcgctca  tgcgggagc  gggcagtgg  ttggctctg  ttcaccgca  1440
cgcccatct  tgctttgta  acactgtac  ttgggacca  ctcttccgg  acccacatc  1500
ggccctgct  cacagtggg  accggccgg  agaggactt  tgcgtctcg  gcggcttgg  1560
ctgtaactc  ctgtgtgcc  acgggcact  ctgggggcc  gggcccacc  agtgtgtca  1620
ctgcagtca  ttccttcgg  gccaggagt  tgtggagga  tgccgagta  ggaaggggc  1680
cccccggga  tatgtgagt  acaagcgct  tctgccgtg  caccccgag  gtcagcctc  1740
aaacagctc  gagacctgc  ttggatcgg  ggctgatca  tgtgcagcc  gcgcccact  1800
caaggactc  tcctcctgt  tggctcgct  ccccagtgg  gtgaaaccg  acctctcct  1860
catgcccat  tggaagtac  cggatgagg  gggcatatg  cagccgtgc  ccatcaact  1920
cacccactc  tgtgtggat  tggatgaac  aggctgccc  gcagagcag  gagccagcc  1980
ggtgacatt  atcattgca  ctgtagagg  cgtcctgct  ttcctgatc  tagtggtgg  2040
cgttggaat  ctaatcaaa  gaaggagac  gaagatccg  aagtatacg  tgcgtaggc  2100
gctgcagga  actgagtta  tggagccgc  gacgcccag  ggagcaatg  ccaaccagg  2160
tcagatgcg  atcctaaaa  agacggagc  aaggaaggt  aaggtgctt  gatcaggag  2220
ttttggcac  gtctacaag  gcatctgga  cccagatgg  gagaatgtg  aaatccccg  2280
ggctatcaa  gtgttgaga  aaaacacat  tcctaaagc  aacaaagaa  ttctagatg  2340
agcgtatgt  atggctggt  tgggttctc  gtatgtgtc  cgcctcctg  gcatctgcc  2400
gacatccac  gtacagctg  tgacacagc  tatgcccta  ggctgcctt  tggaccatg  2460
ccgagaaca  cgaggtcgc  taggctccc  ggacctgct  aactggtgt  ttcagattg  2520
caaggggat  agctacctg  aggacgtgc  gcttgtaca  agggacctg  ctgcccgga  2580
tgtgctagt  aagagtccc  accacgtca  gattacaga  ttcgggctg  ctcggctgc  2640
ggacattga  gagacagag  accatgcag  tgggggcaa  gtgcccatc  aatggatgg  2700
attggaatc  attctcaga  gccggttca  ccatcagag  gatgtgtgg  gctatggag  2760
gactgtgtg  gagctgatg  cttttgggg  caaacctta  gatggaatc  cagcccggg  2820
gatccctga  ttgctggag  agggagaac  cctacctca  cctccaatc  gcaccattg  2880
tgtctacat  attatggtc  aatgttgga  gattgactc  gaatgtcgc  cgagattcc  2940
ggagttggt  tcagaattt  cacgtatgg  gagggaccc  cagcgtttt  tggtcatcc  3000
gaacgagga  ttgggccca  ccagcccca  ggacagtac  ttctaccgt  cactgctgg  3060
agatgatga  atgggtgac  tggtagacg  tgaagagta  ctggtgccc  agcagggat  3120
cttctcccc  gaccctacc  caggcactg  gagcacagc  catagaagg  accgcagct  3180
gtccaccag  agtggaggt  gtgagctga  actgggcct  gagccctcg  aagaagggc  3240
ccccagatc  ccactggct  cctcggaag  ggctggctc  gatgtgttt  atggtgacc  3300
ggcaatggg  gtaaccaaa  ggctgcaga  cctctctcc  catgacctc  gccctctac  3360
gcggtacag  gaggacccc  cattacctc  gccccccga  actgatggc  atgttgctc  3420
cctggcctg  agcccccag  ccgagtatg  gaaccaatc  gaggttcag  ctcagcctc  3480
tttaacccc  gagggtcct  tgcctcctg  ccggcctgc  ggtgctact  tagaaagac  3540
caagactct  tctcctggg  agaatgggg  tgtcaaaga  gtttttgcc  tcgggggtg  3600
tgtggagaa  cctgaatac  tagtaccga  agaaggcac  gcctctccg  cccaccctt  3660
tcctgcctt  agcccagcc  ttgacaacc  ctattactg  gaccagaac  catcggagc  3720
ggggcctcc  ccaagtaac  ttgaaggga  ccccactgc  gagaaccct  agtacctag  3780
cctggatgt  cctgtatga  acgtgtgca  acgtcctgt  ctttcagag  ggggaaggc  3840
tgacttgtg  tctccatcg  cacaaagca  ggagagggt  ctctggcca  attacatcc  3900
gggcagacg  ctctaccag  aacctgccc  gaggaacct  tccttgctg  ttgaa  3955



<210> 9216
<211> 1257
<212> PRT
<213> Rattus norvegicus
<308> P06494
<400> 9216

Met Glu Leu Ala Ala Trp Cys Arg Trp Gly Phe Leu Leu Ala Leu Leu 
  1               5                  10                  15
Pro Pro Gly Ile Ala Gly Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
             20                  25                  30
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
         35                  40                  45
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
     50                  55                  60
Val Pro Ala Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
 65                  70                  75                  80
Gln Gly Tyr Met Leu Ile Ala His Asn Gln Val Lys Arg Val Pro Leu 
                 85                  90                  95
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Lys Tyr 
             100                105                110
Ala Leu Ala Val Leu Asp Asn Arg Asp Pro Gln Asp Asn Val Ala Ala 
         115                120                125
Ser Thr Pro Gly Arg Thr Pro Glu Gly Leu Arg Glu Leu Gln Leu Arg 
     130                135                140
Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Arg Gly Asn Pro 
 145                150                155                160
Gln Leu Cys Tyr Gln Asp Met Val Leu Trp Lys Asp Val Phe Arg Lys 
                 165                170                175
Asn Asn Gln Leu Ala Pro Val Asp Ile Asp Thr Asn Arg Ser Arg Ala 
             180                185                190
Cys Pro Pro Cys Ala Pro Ala Cys Lys Asp Asn His Cys Trp Gly Glu 
         195                200                205
Ser Pro Glu Asp Cys Gln Ile Leu Thr Gly Thr Ile Cys Thr Ser Gly 
     210                215                220
Cys Ala Arg Cys Lys Gly Arg Leu Pro Thr Asp Cys Cys His Glu Gln 
 225                230                235                240
Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys 
                 245                250                255
Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu 
             260                265                270
Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met His Asn Pro Glu Gly 
         275                280                285
Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Thr Cys Pro Tyr Asn Tyr 
     290                295                300
Leu Ser Thr Glu Val Gly Ser Cys Thr Leu Val Cys Pro Pro Asn Asn 
 305                310                315                320
Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser 
                 325                330                335
Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg 
             340                345                350
Gly Ala Arg Ala Ile Thr Ser Asp Asn Val Gln Glu Phe Asp Gly Cys 
         355                360                365
Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly 
     370                375                380
Asp Pro Ser Ser Gly Ile Ala Pro Leu Arg Pro Glu Gln Leu Gln Val 
 385                390                395                400
Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp 
                 405                410                415
Pro Asp Ser Leu Arg Asp Leu Ser Val Phe Gln Asn Leu Arg Ile Ile 
             420                425                430
Arg Gly Arg Ile Leu His Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly 
         435                440                445
Leu Gly Ile His Ser Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser 
     450                455                460
Gly Leu Ala Leu Ile His Arg Asn Ala His Leu Cys Phe Val His Thr 
 465                470                475                480
Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His 
                 485                490                495
Ser Gly Asn Arg Pro Glu Glu Asp Leu Cys Val Ser Ser Gly Leu Val 
             500                505                510
Cys Asn Ser Leu Cys Ala His Gly His Cys Trp Gly Pro Gly Pro Thr 
         515                520                525
Gln Cys Val Asn Cys Ser His Phe Leu Arg Gly Gln Glu Cys Val Glu 
     530                535                540
Glu Cys Arg Val Trp Lys Gly Leu Pro Arg Glu Tyr Val Ser Asp Lys 
 545                550                555                560
Arg Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Ser Ser Glu 
                 565                570                575
Thr Cys Phe Gly Ser Glu Ala Asp Gln Cys Ala Ala Cys Ala His Tyr 
             580                585                590
Lys Asp Ser Ser Ser Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
         595                600                605
Asp Leu Ser Tyr Met Pro Ile Trp Lys Tyr Pro Asp Glu Glu Gly Ile 
     610                615                620
Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 
 625                630                635                640
Glu Arg Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Val Thr Phe Ile 
                 645                650                655
Ile Ala Thr Val Val Gly Val Leu Leu Phe Leu Ile Leu Val Val Val 
             660                665                670
Val Gly Ile Leu Ile Lys Arg Arg Arg Gln Lys Ile Arg Lys Tyr Thr 
         675                680                685
Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro 
     690                695                700
Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr 
 705                710                715                720
Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 
                 725                730                735
Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val 
             740                745                750
Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu 
         755                760                765
Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val 
     770                775                780
Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr 
 785                790                795                800
Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu His Arg 
                 805                810                815
Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Val Gln Ile Ala 
             820                825                830
Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu 
         835                840                845
Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr 
     850                855                860
Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His 
 865                870                875                880
Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 
                 885                890                895
Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 
             900                905                910
Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile 
         915                920                925
Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro 
     930                935                940
Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 
 945                950                955                960
Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser 
                 965                970                975
Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln 
             980                985                990
Asn Glu Asp Leu Gly Pro Ser Ser Pro Met Asp Ser Thr Phe Tyr Arg 
         995                1000                1005
Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu 
     1010                1015                1020
Tyr Leu Val Pro Gln Gln Gly Phe Phe Ser Pro Asp Pro Thr Pro Gly 
 1025                1030                1035                1040
Thr Gly Ser Thr Ala His Arg Arg His Arg Ser Ser Ser Thr Arg Ser 
                 1045                1050                1055
Gly Gly Gly Glu Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu Gly Pro 
             1060                1065                1070
Pro Arg Ser Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe 
         1075                1080                1085
Asp Gly Asp Leu Ala Met Gly Val Thr Lys Gly Leu Gln Ser Leu Ser 
     1090                1095                1100
Pro His Asp Leu Ser Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Leu 
 1105                1110                1115                1120
Pro Leu Pro Pro Glu Thr Asp Gly Tyr Val Ala Pro Leu Ala Cys Ser 
                 1125                1130                1135
Pro Gln Pro Glu Tyr Val Asn Gln Ser Glu Val Gln Pro Gln Pro Pro 
             1140                1145                1150
Leu Thr Pro Glu Gly Pro Leu Pro Pro Val Arg Pro Ala Gly Ala Thr 
         1155                1160                1165
Leu Glu Arg Pro Lys Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys 
     1170                1175                1180
Asp Val Phe Ala Phe Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Val 
 1185                1190                1195                1200
Pro Arg Glu Gly Thr Ala Ser Pro Pro His Pro Ser Pro Ala Phe Ser 
                 1205                1210                1215
Pro Ala Phe Asp Asn Leu Tyr Tyr Trp Asp Gln Asn Ser Ser Glu Gln 
             1220                1225                1230
Gly Pro Pro Pro Ser Asn Phe Glu Gly Thr Pro Thr Ala Glu Asn Pro 
         1235                1240                1245
Glu Tyr Leu Gly Leu Asp Val Pro Val 
     1250                1255



<210> 9217
<211> 4530
<212> DNA
<213> Homo sapiens
<308> M11730
<400> 9217

aattctcga  ctcgtcgac  ggtcgacga  ctcgagggt  gacgagctc  agggcgcgc  60
cccggcccc  acccctcgc  gcaccccgc  ccccgcgcc  tcccagccg  gtccagccg  120
agccatggg  ccggagccg  agtgagcac  atggagctg  cggccttgt  ccgctgggg  180
ctcctcctc  ccctcttgc  ccccggagc  gcgagcacc  aagtgtgca  cggcacaga  240
atgaagctg  ggctccctg  cagtcccga  acccacctg  acatgctcc  ccacctcta  300
cagggctgc  aggtggtgc  gggaaacct  gaactcacc  acctgccca  caatgccag  360
ctgtccttc  tgcaggata  ccaggaggt  cagggctac  tgctcatcg  tcacaacca  420
gtgaggcag  tcccactgc  gaggctgcg  attgtgcga  gcacccagc  ctttgagga  480
aactatgcc  tggccgtgc  agacaatgg  gacccgctg  acaatacca  ccctgtcac  540
ggggcctcc  caggaggcc  gcgggagct  cagcttcga  gcctcacag  gatcttgaa  600
ggaggggtc  tgatccagc  gaaccccca  ctctgctac  aggacacga  tttgtggaa  660
gacatcttc  acaagaaca  ccagctggc  ctcacactg  tagacacca  ccgctctcg  720
gcctgccac  cctgttctc  gatgtgtaa  ggctcccgc  gctggggag  gagttctga  780
gattgtcag  gcctgacgc  cactgtctg  gccggtggc  gtgcccgct  caaggggcc  840
ctgcccact  actgctgcc  tgagcagtg  gctgccggc  gcacgggcc  caagcactc  900
gactgcctg  cctgcctcc  cttcaacca  agtggcatc  gtgagctgc  ctgcccagc  960
ctggtcacc  acaacacag  cacgtttga  tccatgccc  atcccgagg  ccggtatac  1020
ttcggcgcc  gctgtgtga  tgcctgtcc  tacaactac  tttctacgg  cgtgggatc  1080
tgcaccctc  tctgccccc  gcacaacca  gaggtgaca  cagaggatg  aacacagcg  1140
tgtgagaag  gcagcaagc  ctgtgcccg  gtgtgctat  gtctgggca  ggagcactt  1200
cgagaggtg  gggcagtta  cagtgccaa  atccaggag  ttgctggct  caagaagat  1260
tttgggagc  tggcatttc  gccggagag  tttgatggg  acccagcct  caacactgc  1320
ccgctccag  cagagcagc  ccaagtgtt  gagactctg  aagagatca  aggttacct  1380
tacatctca  catggccgg  cagcctgcc  gacctcagc  tcttccaga  cctgcaagt  1440
atccgggga  gaattctgc  caatggcgc  tactcgctg  ccctgcaag  gctgggcat  1500
agctggctg  ggctgcgct  actgaggga  ctgggcagt  gactggccc  catccacca  1560
aacacccac  tctgcttcg  gcacacggt  ccctgggac  agctctttc  gaacccgca  1620
caagctctg  tccacactg  caaccggcc  gaggacgag  gtgtgggcg  gggcctggc  1680
tgccaccag  tgtgcgccc  agggcactg  tggggtcca  ggcccaccc  gtgtgtcaa  1740
tgcagccag  tccttcggg  ccaggagtg  gtggaggaa  gccgagtac  gcaggggct  1800
cccagggag  atgtgaatg  caggcactg  ttgccgtgc  accctgagt  tcagcccca  1860
aatggctca  tgacctgtt  tggaccgga  gctgaccag  gtgtggcct  tgcccacta  1920
aaggaccct  ccttctgcg  ggcccgctg  cccagcggt  tgaaacctg  cctctccta  1980
atgcccatc  ggaagtttc  agatgagga  ggcgcatgc  agccttgcc  catcaactg  2040
acccactcc  gtgtggacc  ggatgacaa  ggctgcccc  ccgagcaga  agccagccc  2100
ctgacgtcc  tcgtctctg  ggtggttgg  attctgctg  tcgtggtct  gggggtggt  2160
tttgggatc  tcatcaagc  acggcagca  aagatccgg  agtacacga  gcggagact  2220
ctgcaggaa  cggagctgg  ggagccgct  acacctagc  gagcgatgc  caaccaggc  2280
cagatgcgg  tcctgaaag  gacggagct  aggaaggtg  aggtgcttg  atctggcgc  2340
tttggcaca  tctacaagg  catctggat  cctgatggg  agaatgtga  aattccagt  2400
gccatcaaa  tgttgaggg  aaacacatc  cccaaagcc  acaaagaaa  cttagacga  2460
gcatacgtg  tggctggtg  gggctcccc  tatgtctcc  gccttctgg  catctgcct  2520
acatccacg  tgcagctgg  gacacagct  atgccctat  gctgcctct  agaccatgt  2580
cgggaaaac  gcggacgcc  gggctccca  gacctgctg  actggtgta  gcagattgc  2640
aaggggatg  gctacctgg  ggatgtgcg  ctcgtacac  gggacttgg  cgctcggaa  2700
gtgctggtc  agagtccca  ccatgtcaa  attacagac  tcgggctgg  tcggctgct  2760
gacattgac  agacagagt  ccatgcaga  gggggcaag  tgcccatca  gtggatggc  2820
ctggagtcc  ttctccgcc  gcggttcac  caccagagt  atgtgtgga  ttatggtgt  2880
actgtgtgg  agctgatga  ttttggggc  aaaccttac  atgggatcc  agcccggga  2940
atccctgac  tgctggaaa  gggggagcg  ctgccccag  cccccatct  caccattga  3000
gtctacatg  tcatggtca  atgttggat  attgactct  aatgtcggc  aagattccg  3060
gagttggtg  ctgaattct  ccgcatggc  agggacccc  agcgctttg  ggtcatcca  3120
aatgaggac  tgggcccag  cagtccctt  gacagcacc  tctaccgct  actgctgga  3180
gacgatgac  tgggggacc  ggtggatgc  gaggagtat  tggtacccc  gcagggctt  3240
ttctgtcca  accctgccc  gggcgctgg  ggcatggtc  accacaggc  ccgcagctc  3300
tctaccagg  gtggcggtg  ggacctgac  ctagggctg  agccctctg  agaggaggc  3360
cccaggtct  cactggcac  ctccgaagg  gctggctcc  atgtatttg  tggtgacct  3420
ggaatgggg  cagccaagg  gctgcaaag  ctccccaca  atgacccca  ccctctaca  3480
cggtacagt  aggacccca  agtacccct  ccctctgag  ctgatggct  cgttgcccc  3540
ctgacctgc  gcccccagc  tgaatatgt  aaccagcca  atgttcggc  ccagccccc  3600
tcgccccga  agggccctc  gcctgctgc  cgacctgct  gtgccactc  ggaaagggc  3660
aagactctc  ccccaggga  gaatggggt  gtcaaagac  tttttgcct  tgggggtgc  3720
gtggagaac  ccgagtact  gacacccca  ggaggagct  cccctcagc  ccaccctcc  3780
cctgccttc  gcccagcct  cgacaacct  tattactgg  accaggacc  accagagcg  3840
ggggctcca  ccagcacct  caaagggac  cctacggca  agaacccag  gtacctggg  3900
ctggacgtg  cagtgtgaa  cagaaggcc  agtccgcag  agccctgat  tgtcctcag  3960
gagcaggga  ggcctgact  ctgctggca  caagaggtg  gagggccct  cgaccactt  4020
caggggaac  tgccatgcc  ggaacctgt  ctaaggaac  ttccttcct  cttgagttc  4080
cagatggct  gaaggggtc  agcctcgtt  gaagaggaa  agcactggg  agtctttgt  4140
gattctgag  ccctgccca  tgagactct  gggtccagt  gatgccaca  cccagcttg  4200
ccctttcct  ccagatcct  ggtactgaa  gccttaggg  agctggcct  agaggggaa  4260
cggccctaa  ggagtgtct  agaacaaaa  cgacccatt  agagactgt  cctgaaacc  4320
agtactgcc  cccatgagg  aggaacagc  atggtgtca  tatccaggc  ttgtacaga  4380
tgcttttct  tttagtttt  acttttttt  ttttgtttt  ttaaagacg  aataaagac  4440
caggggaga  tgggtgttg  atggggagg  aagtgtggg  ggtccttct  cacacccac  4500
ttgtccatt  gcaaatata  tttggaaaac  4530



<210> 9218
<211> 1255
<212> PRT
<213> Homo sapiens
<308> P04626
<400> 9218

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
  1               5                  10                  15
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
             20                  25                  30
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
         35                  40                  45
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
     50                  55                  60
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
 65                  70                  75                  80
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                 85                  90                  95
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
             100                105                110
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
         115                120                125
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
     130                135                140
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
 145                150                155                160
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                 165                170                175
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
             180                185                190
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
         195                200                205
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
     210                215                220
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
 225                230                235                240
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                 245                250                255
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
             260                265                270
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
         275                280                285
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
     290                295                300
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
 305                310                315                320
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                 325                330                335
Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
             340                345                350
Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
         355                360                365
Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
     370                375                380
Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
 385                390                395                400
Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                 405                410                415
Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
             420                425                430
Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
         435                440                445
Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
     450                455                460
Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
 465                470                475                480
Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                 485                490                495
Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
             500                505                510
Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
         515                520                525
Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
     530                535                540
Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
 545                550                555                560
Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                 565                570                575
Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
             580                585                590
Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
         595                600                605
Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
     610                615                620
Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
 625                630                635                640
Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                 645                650                655
Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
             660                665                670
Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
         675                680                685
Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
     690                695                700
Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
 705                710                715                720
Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                 725                730                735
Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
             740                745                750
Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
         755                760                765
Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
     770                775                780
Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
 785                790                795                800
Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                 805                810                815
Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
             820                825                830
Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
         835                840                845
Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
     850                855                860
Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
 865                870                875                880
Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                 885                890                895
Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
             900                905                910
Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
         915                920                925
Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
     930                935                940
Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
 945                950                955                960
Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                 965                970                975
Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
             980                985                990
Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu 
         995                1000                1005
Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu 
     1010                1015                1020
Val Pro Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly 
 1025                1030                1035                1040
Gly Met Val His His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly 
                 1045                1050                1055
Gly Asp Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg 
             1060                1065                1070
Ser Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly 
         1075                1080                1085
Asp Leu Gly Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His 
     1090                1095                1100
Asp Pro Ser Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu 
 1105                1110                1115                1120
Pro Ser Glu Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln 
                 1125                1130                1135
Pro Glu Tyr Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro 
             1140                1145                1150
Arg Glu Gly Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu 
         1155                1160                1165
Arg Pro Lys Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val 
     1170                1175                1180
Phe Ala Phe Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln 
 1185                1190                1195                1200
Gly Gly Ala Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala 
                 1205                1210                1215
Phe Asp Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala 
             1220                1225                1230
Pro Pro Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr 
         1235                1240                1245
Leu Gly Leu Asp Val Pro Val 
     1250                1255



<210> 9219
<211> 1592
<212> DNA
<213> Rattus norvegicus
<308> X03369
<400> 9219

ccaacacca  gcgcgagat  gtgcacatc  aggcgggcc  atgcggcaa  cagatcggc  60
ctaagtttt  ggaggtgat  agcgatgag  atggcatcg  cccgacggg  agctaccat  120
gcgacagtg  cttgcagct  gagagaatc  atgtgtact  caatgaagc  gctggcaac  180
aatatgtac  tcgggccat  ctagtggac  tggagccag  caccatgga  tcagtgagg  240
cgggaccat  cggccagat  ttcaggcca  acaactttg  gttcggtca  agtggtgca  300
gaaataact  ggcaaaggg  cactacaca  agggtgccg  gctggtgga  tctgtcctg  360
atgtggtca  gaaggagtc  gaaagctgt  actgtctcc  gggctttca  ctgacccac  420
cattggggg  aggcactgg  tcaggcatg  ggaccctgc  catcagcaa  atcagagaa  480
agtacccag  ccgcatcat  aacaccttc  gcgtcatgc  ctcacccaa  gtgtcggac  540
ctgtggtgg  gccctataa  gccaccctt  ccgtgcacc  gctggtaga  aacacagac  600
aaacctact  catcgacaa  gaggctctg  atgacatct  cttccgcac  ctgaagctg  660
ccacaccca  ctatggcga  ctcaaccac  tggtgtcag  caccatgag  ggagtgacc  720
cctgcctgc  cttccctgg  cagctgaac  cagacctgc  caagctggc  gtgaacatg  780
tgcctttcc  acgcctgca  ttcttcatg  caggcttcg  acctctgac  agcaggggc  840
gccagcagt  ccgagccct  acagtgccc  agctcaccc  gcagatgtt  gactccaag  900
acatgatgg  tgcctgcga  ccacgccat  gccgctacc  gaccgtagc  gccattttc  960
ggggccgca  gtccatgaa  gaggtggat  agcagatgc  caacgtgca  aacaagaac  1020
gcagctact  cgtggaatg  atccccaac  atgtgaaga  ggccgtgtg  gacatccct  1080
ctcgtggcc  caagatgtc  gccaccttc  ttggcaaca  caccgccat  caagagctg  1140
tcaagcgca  ctcggagca  ttcactgcc  tgttccggc  caaggcctt  ctgcactgg  1200
acacgggcg  gggcatgga  gagatggag  tcaccgagg  ggagagcaa  atgaatgag  1260
tggtgtctg  gtaccagca  taccaggat  ccacggctg  tgagcaggg  gagttcgag  1320
aggaggagg  tgaggatga  gcttgagtt  ccaggccaa  caggttagg  aaagctgag  1380
cgaaaggag  gggtggggg  cttaatctg  gaaaatacc  tggcagttg  aagaaggag  1440
atggtctta  gtttgtgct  ggtctctgg  gctcttact  ttgcctctc  cttttttct  1500
tttttgtaa  atcgatgac  tgatgtgat  cttgagatc  ttctgaact  ctgttgtga  1560
ggctgaaat  gcctgaacc  ttgtgtcct  aa  1592



<210> 9220
<211> 445
<212> PRT
<213> Rattus norvegicus
<308> P04691
<400> 9220

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
  1               5                  10                  15
Gly Pro Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
             20                  25                  30
Thr Gly Ser Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
         35                  40                  45
Val Tyr Tyr Asn Glu Ala Ala Gly Asn Lys Tyr Val Pro Arg Ala Ile 
     50                  55                  60
Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
 65                  70                  75                  80
Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                 85                  90                  95
Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
             100                105                110
Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ser Glu Ser Cys Asp 
         115                120                125
Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
     130                135                140
Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
 145                150                155                160
Asp Arg Ile Met Asn Thr Phe Ser Val Met Pro Ser Pro Lys Val Ser 
                 165                170                175
Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
             180                185                190
Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
         195                200                205
Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
     210                215                220
Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
 225                230                235                240
Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                 245                250                255
Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
             260                265                270
Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
         275                280                285
Leu Thr Gln Gln Met Phe Asp Ser Lys Asn Met Met Ala Ala Cys Asp 
     290                295                300
Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Ile Phe Arg Gly Arg 
 305                310                315                320
Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                 325                330                335
Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
             340                345                350
Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile 
         355                360                365
Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
     370                375                380
Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
 385                390                395                400
Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                 405                410                415
Glu Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Asp Glu 
             420                425                430
Gln Gly Glu Phe Glu Glu Glu Glu Gly Glu Asp Glu Ala 
         435                440                445



<210> 9221
<211> 220
<212> DNA
<213> Homo sapiens
<308> R29239
<400> 9221

cgcaaggcc  tcctgcact  gtacacggg  gagggcatg  acgagatgg  gttcaccga  60
gccgagagc  acatgaatg  cctggtgtc  gagtaccag  agtaccagg  tgccacagc  120
gaggaggag  gcgagttcg  ggaggaggc  gaggaggag  tggcctaga  cttcaatca  180
tgggaaagc  gggaagcag  gtgaactct  tattcactcc  220



<210> 9222
<211> 1485
<212> DNA
<213> Rattus norvegicus
<308> X04070
<400> 9222

cgcagtgcc  gggaggtgt  aatgaggca  gatgaactg  acaggtcta  acaccttgc  60
cagtggcgt  aatcggcat  ctacagcca  tggccgagt  tggctgtcc  tcatcttta  120
cttcagaat  atggtgctg  tggtggctg  agagagcgt  tggggtgat  agaagtctt  180
tttcatctg  aacaccctc  agccgggct  taacagcgt  tgctatgac  attttttcc  240
catctccca  gtgcgcctg  ggtccctgc  actcatctt  gtttccacc  cagctctcc  300
cgtggcaat  cacgtggct  accaacaac  catagaaaa  aaaatgcta  ggcttgagg  360
gcacgggga  ccccttcac  tggaagagg  aaagaggca  aaggtgcac  tctcaggga  420
actgtggtg  acctatgtc  tcagtgtgg  gttccggct  ctgtttgag  ctgtcttca  480
gtatgtctt  tatctgctc  acccgggct  tgccatggt  cggctggtc  agtgtgagg  540
cttcccctg  cccaacacg  tggactgct  cgtgtcccg  cccactgag  aaaccgtct  600
cactgtctt  atgctcgcc  cctccggca  ctgcattat  ctcaacgtg  cggaggtgg  660
gtacctcat  atccgggcc  gtgcccgcc  tgctcagcg  cgctccaat  cgccctccc  720
caagggctc  ggcttcggc  accgcctct  acctgaata  aagcagaat  agatcaaca  780
gctgctgag  gagcaggat  gctctctga  agacatact  cgccgcagt  ctggcactg  840
ggccgggct  gctgagaag  gcgaccgat  ctcagcctg  tgatgccga  taccaggca  900
cctcccatc  aacccctcc  tcaccccac  caggcctgc  cctccttct  ctatgctgg  960
gagcaggcc  ctgcctcct  gggattact  catcaaacc  tccctccct  cctactccc  1020
ttcctcaga  agtcttctg  caaagacct  gccggcttg  gagtgggga  ccacttctg  1080
accagggct  aaggttatt  agggtgtgg  caattcttt  tgcctatac  ctttcctct  1140
ccctctccc  gagatgagg  atgagatgt  ctgaaggtg  ttccaatta  gaaacgtaa  1200
cttaacccc  atgctgtca  gtaccccac  ttgggagtc  tgtcagtgg  gagggctgt  1260
agcaagcag  gtggaggag  ggctctgca  tgtggatgg  gaagggagg  gagcttgcc  1320
tgctgcctg  tacaaggaa  aggaggaca  atctagggt  ggggagttc  ggagggaga  1380
gcaggcaga  aaatcagag  gggggttgg  cagggctgc  cccagtccc  agttcccaa  1440
gcctctctc  ctgaaaatg  tacacatta  acaggattt  acagt  1485



<210> 9223
<211> 283
<212> PRT
<213> Rattus norvegicus
<308> P08033
<400> 9223

Met Asn Trp Thr Gly Leu Tyr Thr Leu Leu Ser Gly Val Asn Arg His 
  1               5                  10                  15
Ser Thr Ala Ile Gly Arg Val Trp Leu Ser Val Ile Phe Ile Phe Arg 
             20                  25                  30
Ile Met Val Leu Val Val Ala Ala Glu Ser Val Trp Gly Asp Glu Lys 
         35                  40                  45
Ser Ser Phe Ile Cys Asn Thr Leu Gln Pro Gly Cys Asn Ser Val Cys 
     50                  55                  60
Tyr Asp His Phe Phe Pro Ile Ser His Val Arg Leu Trp Ser Leu Gln 
 65                  70                  75                  80
Leu Ile Leu Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                 85                  90                  95
His Gln Gln His Ile Glu Lys Lys Met Leu Arg Leu Glu Gly His Gly 
             100                105                110
Asp Pro Leu His Leu Glu Glu Val Lys Arg His Lys Val His Ile Ser 
         115                120                125
Gly Thr Leu Trp Trp Thr Tyr Val Ile Ser Val Val Phe Arg Leu Leu 
     130                135                140
Phe Glu Ala Val Phe Met Tyr Val Phe Tyr Leu Leu Tyr Pro Gly Tyr 
 145                150                155                160
Ala Met Val Arg Leu Val Lys Cys Glu Ala Phe Pro Cys Pro Asn Thr 
                 165                170                175
Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Thr Val 
             180                185                190
Phe Met Leu Ala Ala Ser Gly Ile Cys Ile Ile Leu Asn Val Ala Glu 
         195                200                205
Val Val Tyr Leu Ile Ile Arg Ala Cys Ala Arg Arg Ala Gln Arg Arg 
     210                215                220
Ser Asn Pro Pro Ser Arg Lys Gly Ser Gly Phe Gly His Arg Leu Ser 
 225                230                235                240
Pro Glu Tyr Lys Gln Asn Glu Ile Asn Lys Leu Leu Ser Glu Gln Asp 
                 245                250                255
Gly Ser Leu Lys Asp Ile Leu Arg Arg Ser Pro Gly Thr Gly Ala Gly 
             260                265                270
Leu Ala Glu Lys Ser Asp Arg Cys Ser Ala Cys 
         275                280



<210> 9224
<211> 1561
<212> DNA
<213> Homo sapiens
<308> BC002805
<400> 9224

gacctgtct  ggtggcctc  gggataggc  ctccccaag  tgtgaatga  gcaggatga  60
ctggacagg  ttgtacacc  tgctcagtg  cgtgaaccg  cattctact  ccattggcc  120
agtatggct  tcggtcatc  tcatcttca  aatcatggt  ctggtggtg  ctgcagaga  180
tgtgtgggg  gatgagaaa  cttccttca  ctgcaacac  ctccagcct  gctgcaaca  240
cgtttgcta  gaccaattc  tccccatct  ccatgtgcg  ctgtggtcc  tgcagctca  300
cctagtttc  accccagct  tcctcgtgg  catgcacgt  gctcaccag  aacacatag  360
gaagaaaat  ctacggctt  agggccatg  ggaccccct  cacctggag  aggtgaaga  420
gcacaaggt  cacatctca  ggacactgt  gtggaccta  gtcatcagc  tggtgttcc  480
gctgttgtt  gaggccgtc  tcatgtatg  cttttatct  ctctaccct  gctatgcca  540
ggtgcggct  gtcaagtgc  acgtctacc  ctgccccaa  acagtggac  gcttcgtgt  600
ccgccccac  gagaaaacc  tcttcaccg  cttcatgct  gctgcctct  gcatctgca  660
catcctcaa  gtggccgag  tggtgtacc  catcatccg  gcctgtgcc  gccgagccc  720
gcgccgctc  aatccacct  cccgcaagg  ctcgggctt  ggccaccgc  tctcacctg  780
atacaagca  aatgagatc  acaagctgc  gagtgagca  gatggctcc  tgaaagaca  840
actgcgccg  agccctggc  ccggggctg  gctggctga  aagagcgac  gctgctcgg  900
ctgctgatg  cacatacca  gcaacctcc  atcccaccc  cgaccctgc  ctgggcgag  960
ccctccttc  cccctgccg  tgcacaggc  tctgcctgc  ggggattac  cgatcaaaa  1020
cttccttcc  tggctactt  ccttcctcc  ggggccttc  ttttgagga  ctggagggg  1080
ggggagcta  aggccacct  tgccagtgc  caaggttac  gggagtgtg  gctgccctt  1140
ttgcctgca  ccttccctc  tccctctcc  tctctctgg  accactggg  acaagagat  1200
ggatgctcc  acagcgtct  caattatga  actaatctt  accctgtgc  gtcagatac  1260
ctgtttctg  agtcacatc  gtgaggagg  atgtgggta  gaggagcag  gggcagggg  1320
gctgtggac  tgtgggtgg  gaagggagg  tggccagca  tagtaaagg  ggaatagtg  1380
ttgctggcc  caaggaaaa  gaggaggtg  ctggggtga  ggagttagg  agagagaag  1440
aggcagata  gttggagca  gggttggtc  aggccacct  tgcctctag  ccccaaggc  1500
tctctctgc  tgaaatgtt  cacattaaa  aggatttta  agtaaaaaa  aaaaaaaaa  1560
a  1561



<210> 9225
<211> 283
<212> PRT
<213> Homo sapiens
<308> P08034
<400> 9225

Met Asn Trp Thr Gly Leu Tyr Thr Leu Leu Ser Gly Val Asn Arg His 
  1               5                  10                  15
Ser Thr Ala Ile Gly Arg Val Trp Leu Ser Val Ile Phe Ile Phe Arg 
             20                  25                  30
Ile Met Val Leu Val Val Ala Ala Glu Ser Val Trp Gly Asp Glu Lys 
         35                  40                  45
Ser Ser Phe Ile Cys Asn Thr Leu Gln Pro Gly Cys Asn Ser Val Cys 
     50                  55                  60
Tyr Asp Gln Phe Phe Pro Ile Ser His Val Arg Leu Trp Ser Leu Gln 
 65                  70                  75                  80
Leu Ile Leu Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                 85                  90                  95
His Gln Gln His Ile Glu Lys Lys Met Leu Arg Leu Glu Gly His Gly 
             100                105                110
Asp Pro Leu His Leu Glu Glu Val Lys Arg His Lys Val His Ile Ser 
         115                120                125
Gly Thr Leu Trp Trp Thr Tyr Val Ile Ser Val Val Phe Arg Leu Leu 
     130                135                140
Phe Glu Ala Val Phe Met Tyr Val Phe Tyr Leu Leu Tyr Pro Gly Tyr 
 145                150                155                160
Ala Met Val Arg Leu Val Lys Cys Asp Val Tyr Pro Cys Pro Asn Thr 
                 165                170                175
Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Thr Val 
             180                185                190
Phe Met Leu Ala Ala Ser Gly Ile Cys Ile Ile Leu Asn Val Ala Glu 
         195                200                205
Val Val Tyr Leu Ile Ile Arg Ala Cys Ala Arg Arg Ala Gln Arg Arg 
     210                215                220
Ser Asn Pro Pro Ser Arg Lys Gly Ser Gly Phe Gly His Arg Leu Ser 
 225                230                235                240
Pro Glu Tyr Lys Gln Asn Glu Ile Asn Lys Leu Leu Ser Glu Gln Asp 
                 245                250                255
Gly Ser Leu Lys Asp Ile Leu Arg Arg Ser Pro Gly Thr Gly Ala Gly 
             260                265                270
Leu Ala Glu Lys Ser Asp Arg Cys Ser Ala Cys 
         275                280



<210> 9226
<211> 3237
<212> DNA
<213> Rattus norvegicus
<308> X04979
<400> 9226

cggggatgg  gagagttca  ccgtggcag  ggaatcaac  aagaggggc  agggctaaa  60
ctcagtttt  accccagaa  ctgagcctc  taacagata  agcccccca  ctatttcca  120
ttaagcctc  agccctttt  cgtacaacg  atgcaccag  ccccgcggg  aaggggaga  180
gcagtactc  gtgccccag  accaaggcc  ggattattc  atgaggagt  agctccttt  240
tgggggggg  gggtcacaa  gcatcaaaa  tccacctct  tcctctgcc  tgctgtgaa  300
gggggggga  agcaacccg  ctcgtgaca  ggggttggc  cagcccgcc  tagccctga  360
gagggggcg  gcagggggg  gtcctataa  tggacaggt  tgggatccg  tcccctgct  420
agaccccgg  ggctaagga  ttgtttcgg  aggagctgg  aagacaagc  tgggctggc  480
attcaccca  ggggcttgg  aagacgtgg  caggggacc  tgaaatccg  tggagtcca  540
gaaacaggc  caattatta  aaaagcagg  agcccgata  aagacttag  gtggcgggg  600
gacaaacta  gatcgtgag  taactagcc  ttgccgggg  cagaacaga  ggaggagat  660
gaggggtca  ctccaggag  actgtcggt  cacggcata  gggctcaac  agaaggtag  720
atcaatctt  agcgaagga  ccgcgatga  ccttaggtt  cgtttatgt  aatacctac  780
gatttccat  acagtcccc  aaattaccc  ggccagttt  aaagcgaag  ccctcatgc  840
tgagcgtcc  aagttctgg  gtcgcggga  ggtaccact  cgcagggat  gaggacgat  900
aaaagctta  attagtact  aaccgagag  ccggcttag  agggaaggt  gaaaggaat  960
taaattgga  caccggctg  ccctctgcg  tgtggaatt  gaaccctag  actgggagc  1020
ggaattttt  gcagcgggt  caccccggg  tgctgagat  gagatagga  ggggaggta  1080
atagacctt  gggcagatg  tctattgtg  agatgtttg  gatgactca  agacctgag  1140
agggaatta  ggtgggggc  ctttgggtg  cccgagttt  tccacccct  cccactggt  1200
ttcaaagac  gcttttcct  ccgcagact  gccaatcac  actgggaag  tgaaggctc  1260
gtgggccct  ctgttggtc  cattgctga  aggtatggg  caaggggtg  ctttccctg  1320
tggcaggtt  gggttgggg  agttctgag  cctctgaga  tcaatagcc  tgagcagct  1380
ttttacatg  aggccttgt  tttccctat  cataatatg  gaggattga  gctcagagg  1440
taaaggtgc  tgtcataaa  ctcgaagac  tatctcgga  cccaacatg  tggaaggag  1500
gagcggatt  tctctagtt  tcctctgac  tccaagggt  cacacacag  cacacaatt  1560
aaaagttga  gtgtgtaat  tcttagtcg  ttttaaagg  gaggtatac  ttttctaac  1620
ccataccag  ctagtctca  ctctgttct  cataggata  tagacagtg  atgcttgta  1680
tatctaaac  gactccacg  ctgacttcc  gacgcactg  tgcttcaaa  agacccaag  1740
gcactgtag  tcctgaccc  gccttaaac  tactactct  cacaggatg  ctggccgag  1800
gagagctgg  ggtgacaga  cagctccca  ggcaaagcg  ccaaccctg  gagcaggcc  1860
tgaaccgct  ctgggatta  ctgcgctgg  tgcagacgc  ttctgacca  gtccaggaa  1920
agctgcaga  ctcccaagt  acacaggaa  tgacgtgag  gctcagcgc  tcaccctcc  1980
cacctgctg  gtatccaga  ccaggggtt  ctcctatct  ggcacctac  tacttcttg  2040
ttcctttct  catgagtgt  tgggccagg  tggcttgaa  tctcaatac  tctgctttc  2100
ttagccttc  ggatactgg  atgaacagg  attcattta  gttcttggt  gaatggctt  2160
tggcttttt  agacaggat  ccaatctaa  ttaagctgg  ttcgaaggc  ctgcaattc  2220
ccttcctca  cttctcaac  tctgggaat  caagcgagt  ccaccgcac  tcgctctgt  2280
gtttcctcc  accctaatt  tgacctttt  gtctctgca  tcatctccc  cttgtgttt  2340
ctctgggcc  gcagggtac  gatggagga  actatgact  aagtaaagg  atacaaaaa  2400
gagctggag  aacagctgg  cccagtggc  gaggagaca  gggccaggc  gactaaaga  2460
gtgcaggcg  cacaggccc  tctgggagc  gacatggag  atctacgca  ccgactcgg  2520
cagtaccgc  acgaggtaa  caccatgct  ggccagagc  cagaggagc  gcggtcgcg  2580
ctctccaca  acctgcgca  gatgcgcaa  cgcctgatg  gggatgcgg  tgatctgca  2640
aagcgccta  cggtgtaca  ggccggggc  caggagggc  ccgagcgcg  tgtgagtgc  2700
atccgtgag  gcctggggc  actggtgga  cagggtcgt  agcgcacag  caacctgcg  2760
tggcgccgc  cagccccgc  cgatcgcgc  caggctttg  gtgaccgca  ccgagggcg  2820
ctggaggaa  tgggcaacc  ggcccgaga  cgcctagag  aggtgcgtg  gcagatgga  2880
gaggtgcgc  ccaagatgg  ggagcagac  cagcagata  gcctgcagg  cgagatctt  2940
caggcccgc  tcaagggct  gttcgagcc  ctagtggaa  acatgcagc  ccagtgggc  3000
aacctaatg  agaagatac  ggcctctgt  gctaccaac  ccattgcct  caccacagt  3060
cccctggag  atcaatgat  atccctcac  tacgccctg  cgcaacatc  atgaccagc  3120
aggtggccc  gtcccaagc  ccactctgg  cctctggtg  cccttgctt  ataaagatt  3180
tccaagcac  ttctgagtc  ctgtgagtg  ttccacaca  cttcagcct  agtttat  3237



<210> 9227
<211> 312
<212> PRT
<213> Rattus norvegicus
<308> CAA28650
<400> 9227

Met Lys Ala Leu Trp Ala Leu Leu Leu Val Pro Leu Leu Thr Gly Cys 
  1               5                  10                  15
Leu Ala Glu Gly Glu Leu Glu Val Thr Asp Gln Leu Pro Gly Gln Ser 
             20                  25                  30
Asp Gln Pro Trp Glu Gln Ala Leu Asn Arg Phe Trp Asp Tyr Leu Arg 
         35                  40                  45
Trp Val Gln Thr Leu Ser Asp Gln Val Gln Glu Glu Leu Gln Ser Ser 
     50                  55                  60
Gln Val Thr Gln Glu Leu Thr Val Leu Met Glu Asp Thr Met Thr Glu 
 65                  70                  75                  80
Val Lys Ala Tyr Lys Lys Glu Leu Glu Glu Gln Leu Gly Pro Val Ala 
                 85                  90                  95
Glu Glu Thr Arg Ala Arg Leu Ala Lys Glu Val Gln Ala Ala Gln Ala 
             100                105                110
Arg Leu Gly Ala Asp Met Glu Asp Leu Arg Asn Arg Leu Gly Gln Tyr 
         115                120                125
Arg Asn Glu Val Asn Thr Met Leu Gly Gln Ser Thr Glu Glu Leu Arg 
     130                135                140
Ser Arg Leu Ser Thr His Leu Arg Lys Met Arg Lys Arg Leu Met Arg 
 145                150                155                160
Asp Ala Asp Asp Leu Gln Lys Arg Leu Ala Val Tyr Lys Ala Gly Ala 
                 165                170                175
Gln Glu Gly Ala Glu Arg Gly Val Ser Ala Ile Arg Glu Arg Leu Gly 
             180                185                190
Pro Leu Val Glu Gln Gly Arg Gln Arg Thr Ala Asn Leu Gly Ala Gly 
         195                200                205
Ala Ala Gln Pro Leu Arg Asp Arg Ala Gln Ala Leu Ser Asp Arg Ile 
     210                215                220
Arg Gly Arg Leu Glu Glu Val Gly Asn Gln Ala Arg Asp Arg Leu Glu 
 225                230                235                240
Glu Val Arg Glu Gln Met Glu Glu Val Arg Ser Lys Met Glu Glu Gln 
                 245                250                255
Thr Gln Gln Ile Arg Leu Gln Ala Glu Ile Phe Gln Ala Arg Ile Lys 
             260                265                270
Gly Trp Phe Glu Pro Leu Val Glu Asp Met Gln Arg Gln Trp Ala Asn 
         275                280                285
Leu Met Glu Lys Ile Gln Ala Ser Val Ala Thr Asn Ser Ile Ala Ser 
     290                295                300
Thr Thr Val Pro Leu Glu Asn Gln 
 305                310



<210> 9228
<211> 1156
<212> DNA
<213> Homo sapiens
<308> NM_000041
<400> 9228

cgcagcgga  gtgaaggac  tccttcccc  ggagccgac  ggccaatca  aggcaggaa  60
atgaaggtt  tgtgggctg  gttgctggt  acattcctg  caggatgcc  ggccaaggt  120
gagcaagcg  tggagacag  gccggagcc  gagctgcgc  agcagaccg  gtggcagag  180
ggccagcgc  gggaactgg  actgggtcg  ttttgggat  acctgcgct  ggtgcagac  240
ctgtctgag  aggtgcagg  ggagctgct  agctcccag  tcacccagg  actgagggc  300
ctgatggac  agaccatga  ggagttgaa  gcctacaaa  cggaactgg  ggaacaact  360
accccggtg  cggaggaga  gcgggcacg  ctgtccaag  agctgcagg  ggcgcaggc  420
cggctgggc  cggacatgg  ggacgtgtg  ggccgcctg  tgcagtacc  cggcgaggt  480
caggccatg  tcggccaga  caccgagga  ctgcgggtg  gcctcgcct  ccacctgcg  540
aagctgcgt  agcggctcc  ccgcgatgc  gatgacctg  agaagcgcc  ggcagtgta  600
caggccggg  cccgcgagg  cgccgagcg  ggcctcagc  ccatccgcg  gcgcctggg  660
cccctggtg  aacagggcc  cgtgcgggc  gccactgtg  gctccctgg  cggccagcc  720
ctacaggag  gggcccagg  ctggggcga  cggctgcgc  cgcggatgg  ggagatggg  780
agccggacc  gcgaccgcc  ggacgaggt  aaggagcag  tggcggagg  gcgcgccaa  840
ctggaggag  aggcccagc  gatacgcct  caggccgag  ccttccagg  ccgcctcaa  900
agctggttc  agcccctgg  ggaagacat  cagcgccag  gggccgggc  ggtggagaa  960
gtgcaggct  ccgtgggca  cagcgccgc  cctgtgccc  gcgacaatc  ctgaacgcc  1020
aagcctgca  ccatgcgac  ccacgccac  ccgtgcctc  tgcctccgc  cagcctgca  1080
cgggagacc  tgtccccgc  ccagccgtc  tcctggggt  gaccctagt  taataaaga  1140
tcaccaagt  tcacgc  1156



<210> 9229
<211> 317
<212> PRT
<213> Homo sapiens
<308> P02649
<400> 9229

Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
  1               5                  10                  15
Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
             20                  25                  30
Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
         35                  40                  45
Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
     50                  55                  60
Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
 65                  70                  75                  80
Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                 85                  90                  95
Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
             100                105                110
Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
         115                120                125
Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
     130                135                140
Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
 145                150                155                160
Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                 165                170                175
Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
             180                185                190
Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
         195                200                205
Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 
     210                215                220
Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 
 225                230                235                240
Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 
                 245                250                255
Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
             260                265                270
Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
         275                280                285
Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
     290                295                300
Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
 305                310                315



<210> 9230
<211> 3259
<212> DNA
<213> Rattus norvegicus
<308> X05137
<400> 9230

cagctccgg  gggcagcag  cgctggagc  catcgcagt  cagctcagc  cagcaccat  60
ggtctgcgg  gcggactga  ctagaagcg  agcgctgac  ccggaggcg  gcaatgagg  120
gggcaggtg  tgcctgcag  gccatggac  ggctgcgcc  gctgctgct  ctgattcta  180
gggtgtcct  tggaggtgc  aaggagaca  gttccacag  cctgtacac  cacagcgga  240
agtgctgca  agcctgcaa  ttgggcgaa  gcgtggccc  gccctgcgg  gccaaccag  300
ccgtgtgtg  accctgcct  gacaatgtt  cattctccg  tgtggtgag  gccactgag  360
cgtgcaagc  gtgcaccga  tgcctgggc  tgcagagca  gtccgctcc  tgtgtggag  420
cagacgatg  agtgtgcag  tgtgcctat  gctactacc  ggacgagga  actggccac  480
gtgaggctt  cagcgtgtg  gaggtgggc  cgggactcg  gttctcctg  caggacaaa  540
agaacacag  gtgtgaaga  tgcccagag  gcacatact  agacgaagc  aaccacgtg  600
acccgtgcc  accctgcac  gtgtgcgag  acactgagc  ccagttacg  gagtgcacg  660
cctgggctg  tgctgaatg  gaagagatc  ctggtcgat  gatcccaag  tctacgccc  720
cggagggct  cgacagcac  gcgcccagc  cccaggagc  tgaggttcc  ccagagcaa  780
accttgtac  cagtacagt  gcggatatg  tgaccactg  gatgggcag  tcccagcct  840
tagtgaccc  cggcaccac  gacaacctc  ttcctgtct  ttgctccat  ttggctgct  900
tggtcgtgg  ccttgtggc  tatattgct  tcaagaggt  gaacagctg  aaacaaaat  960
aacaaggcg  caacagccg  cccgtgaac  agacgcccc  accggaggg  gagaaactg  1020
acagcgaca  tggcatctc  gtggacagc  agagcctgc  cgaccagca  acccatacg  1080
agactgcct  aggccaggc  ctcaagggt  atggcaacc  ctacagtag  ctgcccctg  1140
ccaagcgtg  ggaggtaga  aaactgctc  acggggata  ctggcgaca  ctggcaggc  1200
agctgggtt  ccagcctga  catatagac  cctttaccc  cgaggcctg  ccagtgcga  1260
ccctgctgg  cagctgggg  gcccaggac  gtgcaacgc  tgatgccct  ttagccgcc  1320
tgcgacgca  ccagagagc  gacattgtg  agagtctat  cagcgagtc  actgccaca  1380
ccccagtgt  aactcacag  ctgggagcc  ctgtcctgt  ccacattcc  acgactgat  1440
ttctagcca  cccccacag  gctgccccc  ctccctcgg  gatggccca  cggtcagaa  1500
ggagcatct  tgtgcaggg  ctctgtgtt  ccactcctg  ctccgttgc  gctcccgag  1560
gggcccttg  ttctgacca  cctctcctc  gcaagagag  gagagagga  cacccgagc  1620
tgacttgct  catttccat  tcaggcctt  ccttccttt  tacacatta  ctgtgtcag  1680
tctgggggt  tgacactag  agaagggag  gggggcacc  ctaagactc  ggaggtact  1740
aagaaccag  gccatggac  ccacactgt  aaccggaga  caaggggcg  ggcattgtg  1800
taggctaga  cttccttag  ccctccctt  tcccctctg  ccaaagaag  ggattacgg  1860
cctatctga  ctgaaagca  gtttggaac  cagcccaca  ttctctctc  cacacagga  1920
ggtaaaacc  agagaaagg  agggactga  ctaggccac  caaccacag  aagaacaaa  1980
gaaggctga  acactccgt  tctgaatga  ggcgtcaag  gtgcttgtt  acagggatg  2040
cgtgacttt  agggaaata  ctggaagcc  tgtctgccc  gccctcaac  acttccagg  2100
ccctaccca  cccttgtgc  gatgaactg  ttgttcaag  gctggtcca  tggtctatt  2160
tgatggagt  aagctaagg  ctcaggctt  tccataagg  atttgtgga  agatgaatc  2220
gttagtgcg  tcattcttg  cataagcct  aagccaaca  ggcccttaa  gtcagccct  2280
ggggtcagg  accaaggac  cccacccca  aatccaaca  tatactaca  tacacacac  2340
cacacacac  cacacacac  cacacacac  cacacacag  tatcttgct  ttctcccca  2400
ggctctttt  gggctgaga  tagatcctg  tgggagtca  tgccagtga  agatccgga  2460
gggacagag  tgagcttca  ggggctgtc  tcctcgccc  cgggtctgg  aggccaaga  2520
tgactgcat  tgagctggt  tctgtcttc  aatggcctg  gcgtggagg  aatgctccc  2580
ctcctcccc  tcttgaagc  gcccccaga  gactacagt  caaaagagc  gactggtgt  2640
agaacacaa  aaaaagcag  tgctggccc  gcagtctgt  gcagctttc  cctcagctt  2700
aaggcccct  caaaggacg  atttcctga  cacggccag  aaggggcaa  agggttcgg  2760
tcagtggcg  tttctcccg  ctccttggc  tgttctgtt  tgcttgctg  tggaatgag  2820
gggcacccc  tctatttag  atgaaggag  cccaggcag  gtatgcaca  actgaccac  2880
atccctccc  acccagggt  cacccaacc  ggtgaagag  ccaggagca  tgtacgcat  2940
cgcgggtgg  atttttatg  accccaatc  gcaattccc  gacacctgg  aagtgggac  3000
ttctttgtg  atttatttt  ctccccagg  gctggggag  ggtgggggg  tgcaggtac  3060
gtttagcat  tgtttggtt  tgggggtct  tccagcctt  ttttgggcc  agttggaac  3120
tctggccct  cagctggtg  ctatgaact  cagacccct  cgtgctccc  gacgccttc  3180
ccttgcatc  tgtgtaacc  tttcgttgg  ccctcccaa  acctacaca  aaaacatac  3240
ggaggacca  taaattggc  3259



<210> 9231
<211> 425
<212> PRT
<213> Rattus norvegicus
<308> P07174
<400> 9231

Met Arg Arg Ala Gly Ala Ala Cys Ser Ala Met Asp Arg Leu Arg Leu 
  1               5                  10                  15
Leu Leu Leu Leu Ile Leu Gly Val Ser Ser Gly Gly Ala Lys Glu Thr 
             20                  25                  30
Cys Ser Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys 
         35                  40                  45
Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val 
     50                  55                  60
Cys Glu Pro Cys Leu Asp Asn Val Thr Phe Ser Asp Val Val Ser Ala 
 65                  70                  75                  80
Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Leu Gly Leu Gln Ser Met 
                 85                  90                  95
Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr 
             100                105                110
Gly Tyr Tyr Gln Asp Glu Glu Thr Gly His Cys Glu Ala Cys Ser Val 
         115                120                125
Cys Glu Val Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn 
     130                135                140
Thr Val Cys Glu Glu Cys Pro Glu Gly Thr Tyr Ser Asp Glu Ala Asn 
 145                150                155                160
His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg 
                 165                170                175
Gln Leu Arg Glu Cys Thr Pro Trp Ala Asp Ala Glu Cys Glu Glu Ile 
             180                185                190
Pro Gly Arg Trp Ile Pro Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser 
         195                200                205
Thr Ala Pro Ser Thr Gln Glu Pro Glu Val Pro Pro Glu Gln Asp Leu 
     210                215                220
Val Pro Ser Thr Val Ala Asp Met Val Thr Thr Val Met Gly Ser Ser 
 225                230                235                240
Gln Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr 
                 245                250                255
Cys Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala 
             260                265                270
Phe Lys Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala Asn Ser 
         275                280                285
Arg Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu His Ser 
     290                295                300
Asp Ser Gly Ile Ser Val Asp Ser Gln Ser Leu His Asp Gln Gln Thr 
 305                310                315                320
His Thr Gln Thr Ala Ser Gly Gln Ala Leu Lys Gly Asp Gly Asn Leu 
                 325                330                335
Tyr Ser Ser Leu Pro Leu Thr Lys Arg Glu Glu Val Glu Lys Leu Leu 
             340                345                350
Asn Gly Asp Thr Trp Arg His Leu Ala Gly Glu Leu Gly Tyr Gln Pro 
         355                360                365
Glu His Ile Asp Ser Phe Thr His Glu Ala Cys Pro Val Arg Ala Leu 
     370                375                380
Leu Ala Ser Trp Gly Ala Gln Asp Ser Ala Thr Leu Asp Ala Leu Leu 
 385                390                395                400
Ala Ala Leu Arg Arg Ile Gln Arg Ala Asp Ile Val Glu Ser Leu Cys 
                 405                410                415
Ser Glu Ser Thr Ala Thr Ser Pro Val 
             420                425



<210> 9232
<211> 3386
<212> DNA
<213> Homo sapiens
<308> M14764
<400> 9232

gccgcggcc  gctccggcg  gcagggggg  cgctggagc  cagcgcagc  cagccccat  60
agtccgcaa  gcggaccga  ctggaagtc  agcgctgcc  cgggaggcg  gcgatgggg  120
caggtgcca  cggccgcgc  atggacggg  cgcgcctgc  gctgttgct  cttctgggg  180
tgtcccttg  aggtgccaa  gaggcatgc  ccacaggcc  gtacacaca  agcggtgag  240
gctgcaaag  ctgcaacct  ggcgagggt  tggcccagc  ttgtggagc  aaccagacc  300
tgtgtgagc  ctgcctgga  agcgtgacg  tctccgacg  ggtgagcgc  accgagccg  360
gcaagccgt  caccgagtg  gtggggctc  agagcatgt  ggcgccgtg  gtggaggcc  420
acgacgccg  gtgccgctg  gcctacggc  actaccagg  tgagacgac  gggcgctgc  480
aggcgtgcc  cgtgtgcga  gcgggctcg  gcctcgtgt  ctcctgcca  gacaagcag  540
acaccgtgt  cgaggagtg  cccgacggc  cgtattccg  cgaggccaa  cacgtggac  600
cgtgcctgc  ctgcaccgt  tgcgaggac  ccgagcgcc  gctccgcga  tgcacacgc  660
gggccgacg  cgagtgcga  gagatccct  gccgttgga  tacacggtc  acaccccca  720
agggctcgg  cagcacagc  cccagcacc  aggagcctg  ggcacctcc  gaacaagac  780
tcatagcca  cacggtggc  ggtgtggtg  ccacagtga  gggcagctc  cagcccgtg  840
tgacccgag  caccaccga  aacctcatc  ctgtctatt  ctccatcct  gctgctgtg  900
ttgtgggcc  tgtggccta  atagccttc  agaggtgga  cagctgcaa  cagaacaag  960
aaggagcca  cagccggcc  gtgaaccag  cgcccccac  agagggaga  aaactccac  1020
gcgacagtg  catctccgt  gacagccag  gcctgcatg  ccagcagcc  cacacgcag  1080
cagcctcgg  ccaggccct  aagggtgac  gaggcctct  cagcagcct  cccccagcc  1140
agcgggagg  ggtggagaa  cttctcaac  gctctgcgg  ggacacctg  cggcacctg  1200
cgggcgagc  gggctacca  cccgagcac  tagactcct  tacccatga  gcctgcccc  1260
ttcgcgccc  gcttgcaag  tgggccacc  aggacagcg  cacactgga  gccctcctg  1320
ccgccctgc  ccgcatcca  cgagccgac  tcgtggaga  tctgtgcag  gagtccact  1380
ccacatccc  ggtgtgagc  caaccgggg  gcccccgcc  cgccccaca  tccgacaac  1440
gatgctcca  ccaacccct  tggagcccg  acccccacc  tttgggggg  gcccgcctg  1500
cagaactga  ctcctctgg  caggacctc  gagtccagg  cccaaaacc  cagccctgt  1560
agtgcagcc  gtgtggccc  ttcacttct  accacactt  ctgtccaga  agagaagtg  1620
ccctgctgc  tccccaacc  tgcccctgc  ccgtcacca  ctcaggcca  ctgccccct  1680
ctcccacac  gctaggtgg  ccagcccct  ccaccacag  aggtgtcat  tatgggggg  1740
caacaccag  gatggtact  gggggaagt  acaaggccc  agagactca  agggaggaa  1800
cgaggaacc  gagccatgg  ctctacact  tgaacttgg  gaacaaggg  ggcatccca  1860
tggcctcaa  cctccctca  cccctcttg  cccccaccc  agcctaaga  gaagaggat  1920
ggaggcttg  cagagctgg  aggggtttt  gaagctcag  ccacccccc  cattttgga  1980
ataggtcag  gaggcccag  gagaggcca  gattcgccc  aagccagac  gcaacgggg  2040
ggccaagtg  aggctggca  cgccttctc  aaatgaggg  cctcaggtt  gcctgaggg  2100
gaggggagg  tggcaggtg  ccttctggg  aatggcttg  agccaagtc  gctttgcct  2160
ccacgctgt  tccagaccc  caccccttc  ccactgcct  cccacccgt  gagatggga  2220
gcttgccta  ggcctggtc  atgatggag  caggtttgg  gttcgtgga  agggtgctg  2280
ttccctctg  ctgtccctc  caggcatgc  tgtgtgaca  cagtggcat  gctccagtc  2340
gctgccctc  atcccgaca  ggacccgga  ctaacactg  cccctagaa  cagcctagg  2400
gtcagggac  aaggacccc  caccttgca  cacacagac  cacgcacac  cacacacag  2460
aggagaaat  tcacttttc  ccatgagtt  tttctcttg  gctgagact  gatactgcc  2520
ggggcagct  ccagagaag  atcggaggg  attgaggtc  gctcggccg  cttcactcg  2580
ccccgggtt  ggcgggcca  ggactgccg  ccgaggctg  agctggcgt  tgtcttcaa  2640
ggcttacac  tggaggaat  ctcccccat  ctccccttc  ctgcaaaca  ggggttggc  2700
gggcccaga  ggttgcgat  aagaaaagc  ggccagtgt  ggaatgcgg  aagaaggaa  2760
tgacttcga  tgtgacctg  ggggatttc  cccagctct  gacaaccct  caaaggact  2820
ttttttcct  agcttggcc  gaagggggc  atgaggcct  agtggactt  ccaccccct  2880
cctggcctg  tctgttttg  ctgaagttg  agtgagtgt  gctcccctc  atttagcat  2940
acaagcccc  ggcaggctg  gcgctgaca  ccaccgctc  ccagcccag  gttccccca  3000
ccctgtgga  gggactagg  gcactgtag  aaatggcaa  tctttgacc  caacctgtg  3060
tgaggggag  aaactcacc  gctggcccc  cacctgggc  cctggggag  gggacagag  3120
ctgggtgta  ttattttcc  ccccagcag  tggggaggg  gtttggtgg  ttgcaagta  3180
gttttagca  gtgtttggt  ctggggccc  tttttactc  ccttgagct  agatggaac  3240
cttttggcc  ccagctggg  gccatgagc  ccagacccc  agcaaccct  ctatcacct  3300
ccctccttg  ctcctgtgt  atcatttct  gggccctcc  gaaacttac  cacaaaacg  3360
taagtgatg  acattaaat  gcaaag  3386



<210> 9233
<211> 427
<212> PRT
<213> Homo sapiens
<308> P08138
<400> 9233

Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu 
  1               5                  10                  15
Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys 
             20                  25                  30
Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn 
         35                  40                  45
Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys 
     50                  55                  60
Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr 
 65                  70                  75                  80
Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser 
                 85                  90                  95
Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly 
             100                105                110
Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys 
         115                120                125
Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr 
     130                135                140
Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His 
 145                150                155                160
Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln 
                 165                170                175
Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro 
             180                185                190
Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr 
         195                200                205
Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile 
     210                215                220
Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln 
 225                230                235                240
Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr Cys 
                 245                250                255
Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala Phe 
             260                265                270
Lys Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala Asn Ser Arg 
         275                280                285
Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu His Ser Asp 
     290                295                300
Ser Gly Ile Ser Val Asp Ser Gln Ser Leu His Asp Gln Gln Pro His 
 305                310                315                320
Thr Gln Thr Ala Ser Gly Gln Ala Leu Lys Gly Asp Gly Gly Leu Tyr 
                 325                330                335
Ser Ser Leu Pro Pro Ala Lys Arg Glu Glu Val Glu Lys Leu Leu Asn 
             340                345                350
Gly Ser Ala Gly Asp Thr Trp Arg His Leu Ala Gly Glu Leu Gly Tyr 
         355                360                365
Gln Pro Glu His Ile Asp Ser Phe Thr His Glu Ala Cys Pro Val Arg 
     370                375                380
Ala Leu Leu Ala Ser Trp Ala Thr Gln Asp Ser Ala Thr Leu Asp Ala 
 385                390                395                400
Leu Leu Ala Ala Leu Arg Arg Ile Gln Arg Ala Asp Leu Val Glu Ser 
                 405                410                415
Leu Cys Ser Glu Ser Thr Ala Thr Ser Pro Val 
             420                425



<210> 9234
<211> 2214
<212> DNA
<213> Rattus norvegicus
<308> X05300
<400> 9234

tcgcggtca  ggaggcgcc  atcgtcttg  tgctgctgc  atggctcgc  ttggccccg  60
cgcctggca  cgcctcttc  gaggctccg  cgctggtca  cgaggacgt  aagcgcacg  120
tggacctga  cagccacct  gccaaggtg  cggctgagg  ggtcctggc  cacccgggc  180
gcggctcta  agcacgagc  agctctttc  ttctggccc  ggagcccga  ctggagtcg  240
gacttgcac  cctaggcgt  caggtaaag  gagaagatg  ggaagacaa  aacctagaa  300
tacgagaaa  caaaatgaa  gggaaaagt  ggaggtttt  caccgtcaa  ctcccagtt  360
ctcttgatc  tgggtccaa  atctcaatc  ttgtggaaa  tgtctacac  catgtgctt  420
atccatacc  gactcagat  actcagtca  agaaacagt  tgtggtgtt  gagggcaac  480
attacttct  ctctcccta  ccaacaaag  cccagacca  gcgagtgag  cttgcttcc  540
gaaatgtgg  gagccatac  aagctgggg  acccctcaa  gtctgagga  atcctggac  600
atgggcctt  taaagacat  cctgcctac  gtcaggata  tttcaaagt  cattatgag  660
acaatagcc  tttcctgac  atcaccagt  tgacccggg  cattgaggt  tctcactgg  720
gcaatattg  tgtggaaga  aacgtggac  tgaagcata  aggtgcggt  ctgaaggga  780
ctttctccc  ctacgatta  cagaggcag  ctgacagtg  gatctcctc  attcgttct  840
ttaagacca  ccttcctgc  gctgcccag  atgtgtatt  ccgggatga  atcggtaat  900
tttccacca  ccacctcct  attttggat  actccgtgg  aatggaaat  cggcctcga  960
ttggtctct  tggagggtg  aagacacac  acatcgttg  ttacaacct  ccaagctat  1020
agtacctct  taatctggg  gaccagtat  cactgaaga  gcggtttgt  gaccacgtg  1080
ttgatgagc  agtgataga  tctctgaca  tgaagatca  ccttcctga  ggagccaag  1140
acatccagg  agacagtcc  tacgatatt  gccgggccc  agatgagct  cattacacc  1200
acctagaca  attcggccg  ccggtgatt  ttgcttaca  gaagaatct  gttgaacag  1260
acattcagg  cattgtggt  cactacaca  tcaacaagg  gctcatgct  caggagcct  1320
tgctggttg  ggccgcctt  tacatcctg  tcttcaccg  catcatcta  gtccgtcta  1380
acttttcca  caccaagga  ccagcagca  aagccagga  gaaagtggc  tgtatcaca  1440
agcaggtct  aaccctggt  aacaagagg  taggcctct  ccgtcactt  gatgagact  1500
tcaatagat  caagcagtc  cgggacatc  ctaccctca  tagtggcaa  aagagccta  1560
agacagagc  caaagctgt  accagtgag  ttgctgtgc  gcagtctag  ctgaagacg  1620
agggctctg  cctgtgtga  agggtgagc  aaatgcaga  gctggacgc  caggtcaag  1680
agctggtac  gaagtctgc  gtggaggca  agaggctgg  ggctggcaa  ctcaagaag  1740
acacataca  cgagaatga  aagctcagc  caggaaaac  ccaggagct  gtcaccaag  1800
tcgaccaca  cctagacgc  ctgtagctc  tgtctccag  gcaggcctg  gtggcctac  1860
cttctggat  gaataggta  agggaggaa  ttgtgatta  cctaagacc  caagaaaaa  1920
gctgaggcc  atccatggc  gtgtaagaa  cttgtccct  atttctgaa  ggttctctt  1980
tttacaaaa  caaaaacct  aacaaaaat  ctgcccaaa  aacaaactt  gttgtgttt  2040
gagcaaaag  attttgagt  gttgattgc  gttttgttt  gatacctgg  tattttttc  2100
gtctgtaag  cctgtttta  ggccttctg  ttcctaatg  ttggttctt  tgtgagcgt  2160
tgcatggtt  tttaaaagt  tgtatgacc  aataaaaat  aaggaggga  tgtg  2214



<210> 9235
<211> 605
<212> PRT
<213> Rattus norvegicus
<308> P07153
<400> 9235

Met Glu Ala Pro Ile Val Leu Leu Leu Leu Leu Trp Leu Ala Leu Ala 
  1               5                  10                  15
Pro Thr Pro Gly Ser Ala Ser Ser Glu Ala Pro Pro Leu Val Asn Glu 
             20                  25                  30
Asp Val Lys Arg Thr Val Asp Leu Ser Ser His Leu Ala Lys Val Thr 
         35                  40                  45
Ala Glu Val Val Leu Ala His Pro Gly Gly Gly Ser Thr Ala Arg Ala 
     50                  55                  60
Ser Ser Phe Val Leu Ala Leu Glu Pro Glu Leu Glu Ser Arg Leu Ala 
 65                  70                  75                  80
His Leu Gly Val Gln Val Lys Gly Glu Asp Glu Glu Asp Asn Asn Leu 
                 85                  90                  95
Glu Val Arg Glu Thr Lys Met Lys Gly Lys Ser Gly Arg Phe Phe Thr 
             100                105                110
Val Lys Leu Pro Val Ala Leu Asp Pro Gly Ser Lys Ile Ser Ile Val 
         115                120                125
Val Glu Thr Val Tyr Thr His Val Leu His Pro Tyr Pro Thr Gln Ile 
     130                135                140
Thr Gln Ser Glu Lys Gln Phe Val Val Phe Glu Gly Asn His Tyr Phe 
 145                150                155                160
Tyr Ser Pro Tyr Pro Thr Lys Thr Gln Thr Met Arg Val Arg Leu Ala 
                 165                170                175
Ser Arg Asn Val Glu Ser His Thr Lys Leu Gly Asn Pro Ser Arg Ser 
             180                185                190
Glu Asp Ile Leu Asp Tyr Gly Pro Phe Lys Asp Ile Pro Ala Tyr Ser 
         195                200                205
Gln Asp Thr Phe Lys Val His Tyr Glu Asn Asn Ser Pro Phe Leu Thr 
     210                215                220
Ile Thr Ser Met Thr Arg Val Ile Glu Val Ser His Trp Gly Asn Ile 
 225                230                235                240
Ala Val Glu Glu Asn Val Asp Leu Lys His Thr Gly Ala Val Leu Lys 
                 245                250                255
Gly Pro Phe Ser Arg Tyr Asp Tyr Gln Arg Gln Pro Asp Ser Gly Ile 
             260                265                270
Ser Ser Ile Arg Ser Phe Lys Thr Ile Leu Pro Ala Ala Ala Gln Asp 
         275                280                285
Val Tyr Tyr Arg Asp Glu Ile Gly Asn Val Ser Thr Ser His Leu Leu 
     290                295                300
Ile Leu Asp Asp Ser Val Glu Met Glu Ile Arg Pro Arg Phe Gly Leu 
 305                310                315                320
Phe Gly Gly Trp Lys Thr His Tyr Ile Val Gly Tyr Asn Leu Pro Ser 
                 325                330                335
Tyr Glu Tyr Leu Tyr Asn Leu Gly Asp Gln Tyr Ala Leu Lys Met Arg 
             340                345                350
Phe Val Asp His Val Phe Asp Glu Gln Val Ile Asp Ser Leu Thr Val 
         355                360                365
Lys Ile Ile Leu Pro Glu Gly Ala Lys Asn Ile Gln Val Asp Ser Pro 
     370                375                380
Tyr Asp Ile Ser Arg Ala Pro Asp Glu Leu His Tyr Thr Tyr Leu Asp 
 385                390                395                400
Thr Phe Gly Arg Pro Val Ile Val Ala Tyr Lys Lys Asn Leu Val Glu 
                 405                410                415
Gln His Ile Gln Asp Ile Val Val His Tyr Thr Phe Asn Lys Val Leu 
             420                425                430
Met Leu Gln Glu Pro Leu Leu Val Val Ala Ala Phe Tyr Ile Leu Phe 
         435                440                445
Phe Thr Val Ile Ile Tyr Val Arg Leu Asp Phe Ser Ile Thr Lys Asp 
     450                455                460
Pro Ala Ala Glu Ala Arg Met Lys Val Ala Cys Ile Thr Glu Gln Val 
 465                470                475                480
Leu Thr Leu Val Asn Lys Arg Leu Gly Leu Tyr Arg His Phe Asp Glu 
                 485                490                495
Thr Val Asn Arg Tyr Lys Gln Ser Arg Asp Ile Ser Thr Leu Asn Ser 
             500                505                510
Gly Lys Lys Ser Leu Glu Thr Glu His Lys Ala Val Thr Ser Glu Ile 
         515                520                525
Ala Val Leu Gln Ser Arg Leu Lys Thr Glu Gly Ser Asp Leu Cys Asp 
     530                535                540
Arg Val Ser Glu Met Gln Lys Leu Asp Ala Gln Val Lys Glu Leu Val 
 545                550                555                560
Leu Lys Ser Ala Val Glu Ala Glu Arg Leu Val Ala Gly Lys Leu Lys 
                 565                570                575
Lys Asp Thr Tyr Ile Glu Asn Glu Lys Leu Ser Ser Gly Lys Arg Gln 
             580                585                590
Glu Leu Val Thr Lys Ile Asp His Ile Leu Asp Ala Leu 
         595                600                605



<210> 9236
<211> 2397
<212> DNA
<213> Homo sapiens
<308> Y00281
<400> 9236

ttagctagg  atggtggca  atgcctgta  tcccagcta  tcgggaggc  gaggcagga  60
aattgcttg  acccgggag  cagaggttg  agccggctg  gatggcgcc  tcacactcc  120
gcctgctct  cccggtcat  gaggcgcca  ccgccggct  gtttctgct  ctgttgctt  180
ggacttggg  cccggcgcc  ggcagcgcc  cctccgagg  accgccgct  atcaatgag  240
acgtgaagc  cacagtgga  ctaagcagc  acctggcta  ggtgacggc  gaggtggtc  300
tggcgcacc  gggcggcgg  tccacgtcc  gagctacct  tttcctgct  gctttggag  360
ctgagctcg  ggcccggct  gcgcacctg  gcgtgcagg  aaagggaga  gatgaggaa  420
agaacaatt  ggaagtacg  gaaaccaaa  ttaagggta  aagtgggag  ttcttcaca  480
tcaagctcc  agttgctct  gatcctggg  ccaagattt  agtcattgt  gaaacagtc  540
acacccatg  gcttcatcc  tatccaacc  agatcaccc  gtcagagaa  cagtttgtg  600
tgtttgagg  gaaccatta  ttctactct  cctatccaa  gaagacaca  accatgcgt  660
tgaagcttg  ctctcgaaa  gtggagagc  acaccaagc  ggggaaccc  acgcgctct  720
aggacctac  ggattatgg  cctttcaga  atgtgcctg  ctatagtca  gatactttt  780
aagtacatt  tgagaacaa  agccctttc  tgaccatca  cagcatgac  cgagtcatt  840
aagtctctc  ctggggtaa  attgctgtg  aagaaaatg  ggacttaaa  cacacagga  900
ctgtgctta  ggggccttt  tcacgctat  attaccaga  acagccaga  agtggaata  960
cctccatcc  ttcttttaa  accatcctt  ctgctgctg  ccaggatgt  tattaccgg  1020
atgagattg  caatgtttc  accagccac  tccttattt  ggatgactc  gtagagatg  1080
aaatccggc  tcgcttccc  ctctttggc  ggtggaaga  ccattacat  gttggctac  1140
acctcccaa  ctatgagta  ctctataat  tgggtgacc  gtatgcact  aagatgagg  1200
ttgtggacc  tgtgtttga  gaacaagtg  tagattctc  gactgtgaa  atcatcctg  1260
ctgaaggag  caagaacat  gaaattgat  gtccctatg  aatcagccg  gccccagat  1320
agctgcact  cacctatct  gatacattt  gccgccctg  gattgttgc  tacaagaaa  1380
atctggtag  acagcacat  caggacatt  tggtccact  cacgttcaa  aaggtgctc  1440
tgctgcagg  gcccctgct  gtggtggcg  ccttctaca  cctgttctt  accgttatc  1500
tctatgttc  gctggactt  tccatcacc  aggatccag  cgcagaagc  aggatgaag  1560
tagcctgca  cacagagca  gtcttgacc  tggtcaaca  gagaatagg  ctttaccgt  1620
actttgacg  gaccgtcaa  aggtacaag  aatcccggg  catctccac  ctcaacagt  1680
gcaagaaga  cctggagac  gaacacaag  ccttgacca  tgagattgc  ctgctgcag  1740
ccaggctga  gacagaggg  tctgatctg  gcgacagag  gagcgaaat  cagaagctg  1800
atgcacagg  caaggagct  gtgctgaag  cggcggtgg  ggctgagcg  ctggtggct  1860
gcaagctca  gaaagacac  tacattgag  atgagaagc  catctcagg  aagcgccag  1920
agctggtca  caagatcga  cacatcctg  atgccctgt  gcccctgcc  gcatcctcc  1980
gggggccca  ggtgcctgc  ctttgctgt  gcaggcaga  tgggtggta  tgggaggtt  2040
tgcatggag  ccagtgaaa  ctgacatct  taaaaggcc  tcaaggaag  gaaaccagg  2100
cctgcgtca  gcagtgtga  tttgccgtt  gtccttaac  ttctttttt  tttttttta  2160
aaaagaaaa  tttaaaaaa  ctcccatta  aaacaaaac  tctttgtgt  gtgaacaaa  2220
gaattttca  tatttgatt  gtattctgt  ctgaagtct  ggatatttt  cagcctata  2280
agccccctg  tttatgccc  tctaattct  atgtttggg  attgtgtga  tgcatgtgt  2340
ttttttttt  tttttttaa  gcgtgtgtg  acaaatgga  ataaagcag  gactgtg  2397



<210> 9237
<211> 607
<212> PRT
<213> Homo sapiens
<308> P04843
<400> 9237

Met Glu Ala Pro Ala Ala Gly Leu Phe Leu Leu Leu Leu Leu Gly Thr 
  1               5                  10                  15
Trp Ala Pro Ala Pro Gly Ser Ala Ser Ser Glu Ala Pro Pro Leu Ile 
             20                  25                  30
Asn Glu Asp Val Lys Arg Thr Val Asp Leu Ser Ser His Leu Ala Lys 
         35                  40                  45
Val Thr Ala Glu Val Val Leu Ala His Leu Gly Gly Gly Ser Thr Ser 
     50                  55                  60
Arg Ala Thr Ser Phe Leu Leu Ala Leu Glu Pro Glu Leu Glu Ala Arg 
 65                  70                  75                  80
Leu Ala His Leu Gly Val Gln Val Lys Gly Glu Asp Glu Glu Glu Asn 
                 85                  90                  95
Asn Leu Glu Val Arg Glu Thr Lys Ile Lys Gly Lys Ser Gly Arg Phe 
             100                105                110
Phe Thr Val Lys Leu Pro Val Ala Leu Asp Pro Gly Ala Lys Ile Ser 
         115                120                125
Val Ile Val Glu Thr Val Tyr Thr His Val Leu His Pro Tyr Pro Thr 
     130                135                140
Gln Ile Thr Gln Ser Glu Lys Gln Phe Val Val Phe Glu Gly Asn His 
 145                150                155                160
Tyr Phe Tyr Ser Pro Tyr Pro Thr Lys Thr Gln Thr Met Arg Val Lys 
                 165                170                175
Leu Ala Ser Arg Asn Val Glu Ser Tyr Thr Lys Leu Gly Asn Pro Thr 
             180                185                190
Arg Ser Glu Asp Leu Leu Asp Tyr Gly Pro Phe Arg Asp Val Pro Ala 
         195                200                205
Tyr Ser Gln Asp Thr Phe Lys Val His Tyr Glu Asn Asn Ser Pro Phe 
     210                215                220
Leu Thr Ile Thr Ser Met Thr Arg Val Ile Glu Val Ser His Trp Gly 
 225                230                235                240
Asn Ile Ala Val Glu Glu Asn Val Asp Leu Lys His Thr Gly Ala Val 
                 245                250                255
Leu Lys Gly Pro Phe Ser Arg Tyr Asp Tyr Gln Arg Gln Pro Asp Ser 
             260                265                270
Gly Ile Ser Ser Ile Arg Ser Phe Lys Thr Ile Leu Pro Ala Ala Ala 
         275                280                285
Gln Asp Val Tyr Tyr Arg Asp Glu Ile Gly Asn Val Ser Thr Ser His 
     290                295                300
Leu Leu Ile Leu Asp Asp Ser Val Glu Met Glu Ile Arg Pro Arg Phe 
 305                310                315                320
Pro Leu Phe Gly Gly Trp Lys Thr His Tyr Ile Val Gly Tyr Asn Leu 
                 325                330                335
Pro Ser Tyr Glu Tyr Leu Tyr Asn Leu Gly Asp Gln Tyr Ala Leu Lys 
             340                345                350
Met Arg Phe Val Asp His Val Phe Asp Glu Gln Val Ile Asp Ser Leu 
         355                360                365
Thr Val Lys Ile Ile Leu Pro Glu Gly Ala Lys Asn Ile Glu Ile Asp 
     370                375                380
Ser Pro Tyr Glu Ile Ser Arg Ala Pro Asp Glu Leu His Tyr Thr Tyr 
 385                390                395                400
Leu Asp Thr Phe Gly Arg Pro Val Ile Val Ala Tyr Lys Lys Asn Leu 
                 405                410                415
Val Glu Gln His Ile Gln Asp Ile Val Val His Tyr Thr Phe Asn Lys 
             420                425                430
Val Leu Met Leu Gln Glu Pro Leu Leu Val Val Ala Ala Phe Tyr Ile 
         435                440                445
Leu Phe Phe Thr Val Ile Ile Tyr Val Arg Leu Asp Phe Ser Ile Thr 
     450                455                460
Lys Asp Pro Ala Ala Glu Ala Arg Met Lys Val Ala Cys Ile Thr Glu 
 465                470                475                480
Gln Val Leu Thr Leu Val Asn Lys Arg Ile Gly Leu Tyr Arg His Phe 
                 485                490                495
Asp Glu Thr Val Asn Arg Tyr Lys Gln Ser Arg Asp Ile Ser Thr Leu 
             500                505                510
Asn Ser Gly Lys Lys Ser Leu Glu Thr Glu His Lys Ala Leu Thr Ser 
         515                520                525
Glu Ile Ala Leu Leu Gln Ser Arg Leu Lys Thr Glu Gly Ser Asp Leu 
     530                535                540
Cys Asp Arg Val Ser Glu Met Gln Lys Leu Asp Ala Gln Val Lys Glu 
 545                550                555                560
Leu Val Leu Lys Ser Ala Val Glu Ala Glu Arg Leu Val Ala Gly Lys 
                 565                570                575
Leu Lys Lys Asp Thr Tyr Ile Glu Asn Glu Lys Leu Ile Ser Gly Lys 
             580                585                590
Arg Gln Glu Leu Val Thr Lys Ile Asp His Ile Leu Asp Ala Leu 
         595                600                605



<210> 9238
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9238

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9239
<211> 140
<212> PRT
<213> Rattus norvegicus
<308> CAA29032
<400> 9239

Asp Glu Leu Ser Ile Leu Asn Ile Tyr Ala Pro Asn Thr Arg Ala Pro 
  1               5                  10                  15
Thr Tyr Val Lys Glu Thr Leu Leu Lys Leu Lys Ala His Ile Ala Pro 
             20                  25                  30
His Thr Ile Ile Met Gly Asp Phe Asn Thr Pro Leu Ser Ser Met Asp 
         35                  40                  45
Arg Ser Trp Lys Gln Ile Leu Ser Asn Asp Val Asp Arg Leu Arg Glu 
     50                  55                  60
Ala Met Ser Gln Met Gly Leu Thr Asp Ile Tyr Arg Thr Phe Tyr Pro 
 65                  70                  75                  80
Lys Ala Lys Gly Tyr Thr Phe Phe Ser Ala Pro His Gly Thr Phe Ser 
                 85                  90                  95
Lys Ile Asp His Ile Ile Gly Gln Lys Thr Gly Leu Asn Arg Tyr Arg 
             100                105                110
Lys Ile Glu Ile Ile Pro Cys Val Leu Ser Asp His His Gly Leu Lys 
         115                120                125
Leu Val Phe Asn Asn Asn Lys Gly Arg Met Pro Thr 
     130                135                140



<210> 9240
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9240

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9241
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9241

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9242
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9242

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9243
<211> 140
<212> PRT
<213> Rattus norvegicus
<308> CAA29032
<400> 9243

Asp Glu Leu Ser Ile Leu Asn Ile Tyr Ala Pro Asn Thr Arg Ala Pro 
  1               5                  10                  15
Thr Tyr Val Lys Glu Thr Leu Leu Lys Leu Lys Ala His Ile Ala Pro 
             20                  25                  30
His Thr Ile Ile Met Gly Asp Phe Asn Thr Pro Leu Ser Ser Met Asp 
         35                  40                  45
Arg Ser Trp Lys Gln Ile Leu Ser Asn Asp Val Asp Arg Leu Arg Glu 
     50                  55                  60
Ala Met Ser Gln Met Gly Leu Thr Asp Ile Tyr Arg Thr Phe Tyr Pro 
 65                  70                  75                  80
Lys Ala Lys Gly Tyr Thr Phe Phe Ser Ala Pro His Gly Thr Phe Ser 
                 85                  90                  95
Lys Ile Asp His Ile Ile Gly Gln Lys Thr Gly Leu Asn Arg Tyr Arg 
             100                105                110
Lys Ile Glu Ile Ile Pro Cys Val Leu Ser Asp His His Gly Leu Lys 
         115                120                125
Leu Val Phe Asn Asn Asn Lys Gly Arg Met Pro Thr 
     130                135                140



<210> 9244
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9244

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9245
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9245

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9246
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9246

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9247
<211> 140
<212> PRT
<213> Rattus norvegicus
<308> CAA29032
<400> 9247

Asp Glu Leu Ser Ile Leu Asn Ile Tyr Ala Pro Asn Thr Arg Ala Pro 
  1               5                  10                  15
Thr Tyr Val Lys Glu Thr Leu Leu Lys Leu Lys Ala His Ile Ala Pro 
             20                  25                  30
His Thr Ile Ile Met Gly Asp Phe Asn Thr Pro Leu Ser Ser Met Asp 
         35                  40                  45
Arg Ser Trp Lys Gln Ile Leu Ser Asn Asp Val Asp Arg Leu Arg Glu 
     50                  55                  60
Ala Met Ser Gln Met Gly Leu Thr Asp Ile Tyr Arg Thr Phe Tyr Pro 
 65                  70                  75                  80
Lys Ala Lys Gly Tyr Thr Phe Phe Ser Ala Pro His Gly Thr Phe Ser 
                 85                  90                  95
Lys Ile Asp His Ile Ile Gly Gln Lys Thr Gly Leu Asn Arg Tyr Arg 
             100                105                110
Lys Ile Glu Ile Ile Pro Cys Val Leu Ser Asp His His Gly Leu Lys 
         115                120                125
Leu Val Phe Asn Asn Asn Lys Gly Arg Met Pro Thr 
     130                135                140



<210> 9248
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9248

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9249
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9249

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9250
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9250

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9251
<211> 140
<212> PRT
<213> Rattus norvegicus
<308> CAA29032
<400> 9251

Asp Glu Leu Ser Ile Leu Asn Ile Tyr Ala Pro Asn Thr Arg Ala Pro 
  1               5                  10                  15
Thr Tyr Val Lys Glu Thr Leu Leu Lys Leu Lys Ala His Ile Ala Pro 
             20                  25                  30
His Thr Ile Ile Met Gly Asp Phe Asn Thr Pro Leu Ser Ser Met Asp 
         35                  40                  45
Arg Ser Trp Lys Gln Ile Leu Ser Asn Asp Val Asp Arg Leu Arg Glu 
     50                  55                  60
Ala Met Ser Gln Met Gly Leu Thr Asp Ile Tyr Arg Thr Phe Tyr Pro 
 65                  70                  75                  80
Lys Ala Lys Gly Tyr Thr Phe Phe Ser Ala Pro His Gly Thr Phe Ser 
                 85                  90                  95
Lys Ile Asp His Ile Ile Gly Gln Lys Thr Gly Leu Asn Arg Tyr Arg 
             100                105                110
Lys Ile Glu Ile Ile Pro Cys Val Leu Ser Asp His His Gly Leu Lys 
         115                120                125
Leu Val Phe Asn Asn Asn Lys Gly Arg Met Pro Thr 
     130                135                140



<210> 9252
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9252

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9253
<211> 140
<212> PRT
<213> Rattus norvegicus
<308> CAA29032
<400> 9253

Asp Glu Leu Ser Ile Leu Asn Ile Tyr Ala Pro Asn Thr Arg Ala Pro 
  1               5                  10                  15
Thr Tyr Val Lys Glu Thr Leu Leu Lys Leu Lys Ala His Ile Ala Pro 
             20                  25                  30
His Thr Ile Ile Met Gly Asp Phe Asn Thr Pro Leu Ser Ser Met Asp 
         35                  40                  45
Arg Ser Trp Lys Gln Ile Leu Ser Asn Asp Val Asp Arg Leu Arg Glu 
     50                  55                  60
Ala Met Ser Gln Met Gly Leu Thr Asp Ile Tyr Arg Thr Phe Tyr Pro 
 65                  70                  75                  80
Lys Ala Lys Gly Tyr Thr Phe Phe Ser Ala Pro His Gly Thr Phe Ser 
                 85                  90                  95
Lys Ile Asp His Ile Ile Gly Gln Lys Thr Gly Leu Asn Arg Tyr Arg 
             100                105                110
Lys Ile Glu Ile Ile Pro Cys Val Leu Ser Asp His His Gly Leu Lys 
         115                120                125
Leu Val Phe Asn Asn Asn Lys Gly Arg Met Pro Thr 
     130                135                140



<210> 9254
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9254

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9255
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9255

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9256
<211> 140
<212> PRT
<213> Rattus norvegicus
<308> CAA29032
<400> 9256

Asp Glu Leu Ser Ile Leu Asn Ile Tyr Ala Pro Asn Thr Arg Ala Pro 
  1               5                  10                  15
Thr Tyr Val Lys Glu Thr Leu Leu Lys Leu Lys Ala His Ile Ala Pro 
             20                  25                  30
His Thr Ile Ile Met Gly Asp Phe Asn Thr Pro Leu Ser Ser Met Asp 
         35                  40                  45
Arg Ser Trp Lys Gln Ile Leu Ser Asn Asp Val Asp Arg Leu Arg Glu 
     50                  55                  60
Ala Met Ser Gln Met Gly Leu Thr Asp Ile Tyr Arg Thr Phe Tyr Pro 
 65                  70                  75                  80
Lys Ala Lys Gly Tyr Thr Phe Phe Ser Ala Pro His Gly Thr Phe Ser 
                 85                  90                  95
Lys Ile Asp His Ile Ile Gly Gln Lys Thr Gly Leu Asn Arg Tyr Arg 
             100                105                110
Lys Ile Glu Ile Ile Pro Cys Val Leu Ser Asp His His Gly Leu Lys 
         115                120                125
Leu Val Phe Asn Asn Asn Lys Gly Arg Met Pro Thr 
     130                135                140



<210> 9257
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9257

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9258
<211> 1121
<212> DNA
<213> Rattus norvegicus
<308> X05472
<400> 9258

aagatgaac  ctcaatcct  aatatctat  ccccaaata  aagggcacc  acatacgta  60
aagaaacct  actaaagct  aaagcacac  ttgcacctc  cacaataat  atgggagat  120
tcaacacac  actctcatc  atggacaga  catggaaac  gatattaag  aatgatgtc  180
acagactaa  agaagccat  agccaaatg  gcttaacgg  tatttatag  acattctat  240
ctaaagcaa  aggatatac  ttcttctca  ctcctcatg  tactttctc  aaaattgac  300
atataattg  tcaaaaaac  ggcctcaac  ggtacagaa  gatagaaat  atcccatgc  360
tgctatcgg  ccaccacgg  ctaaaactg  tcttcaata  caataaggg  agaatgccc  420
catagacgt  gaaattgaa  aatgctata  tcaatgata  cctggtcaa  gaagaaata  480
agaaagaaa  taaaaactt  ttagaattt  atgaaaatg  agatacaac  tacccaaac  540
tatgggaca  aatgaaagc  gtgctaaga  gaaaactca  agcgctgag  gcctgcaga  600
agaaacagg  aagagcata  gtcagcagc  tgacagcac  cctaaaagc  ctagaacaa  660
aagaagcaa  tacacccag  aggagtaga  ggcaggaaa  aatcaaact  agagctgaa  720
taaaccaag  agaaacaaa  agtaccata  aaagaatca  cagaaccaa  agttggttc  780
ttgagaaaa  caacaagat  gataaaccc  tagccacac  aacgagagg  cacagagag  840
gcgtccaaa  taacaaaat  agaaatgaa  agggagaca  aactacaga  tcagaggaa  900
ttcaaaaaa  catcagatc  tactataaa  acctatatt  aaaaaaact  gaaaatttt  960
aggaaatgg  caatttcct  gacagatac  aggtattga  gttaaatca  gaacagata  1020
accagttaa  caaccccat  actcctaag  aaatagaag  agtcattaa  ggtctccca  1080
ccaaaaaga  cccaggtcc  gacgggttt  gtgcagaat  c  1121



<210> 9259
<211> 1114
<212> DNA
<213> Rattus norvegicus
<308> X05834
<400> 9259

acaattgct  gtcttttga  actagatag  tatcctttc  ataaaacac  gtgacacat  60
tccccaccc  cacccccca  acttgtttt  cggagtatc  gctactaat  tttttcttc  120
attttgaca  aatgtaaat  gcccaattg  atgcttcat  ccgttggac  tgcaggctg  180
cagagatga  tccagagag  aatctttcc  tccagccca  gccaacaag  gtctctcta  240
caaggtcaa  ccacacccc  gtgatgtta  cagaccctc  atttctgag  ggtcatttc  300
cccttaagc  ttctgctct  gagtcaagt  ctcagcttc  gctcaactt  cagcttctc  360
aagcatcgc  ccgcgggat  ttttgagac  tccctctta  atggtgaca  ttggtgccc  420
gttctgctt  agggtattc  gtactgctc  gtattattg  ctaagagaa  caaaagttc  480
tgtgatttg  tctgggatc  aagggaaac  caggtagcc  accacgatg  aatgaattg  540
atggtagta  ccaagagcg  gagcaggaa  ttaaaccag  cagttctgc  ttcttttgc  600
gtctgatct  cagcactgt  aggaggcct  tcctgtggc  gtgtccaaa  accccacag  660
actcactgt  ccaacaatc  taattgcct  gaaatatct  tctcttacc  gttatttat  720
aatttttcc  agtattttt  tacggaaaa  attgtattg  agacacttt  tatgcagtt  780
ataagagga  ttcagtata  ttatggttg  tgactattt  tataatgta  atgccaaca  840
tttactact  tggaaagac  agtgtttta  taaaaagat  tacattcca  gatgtggag  900
tcatttctt  tttaacata  tgtacctag  gagaaaaat  ataatcttc  tgaatgtcc  960
ttagtctct  tgttgggct  gggtggttt  tgcacatga  ctcctgctg  tcttacaga  1020
gcaccgata  tttttgtca  tttgtgttc  gtgttctca  ttgtgattt  aatggactc  1080
aatgtatgc  agcttgcta  ctagcttat  gaag  1114



<210> 9260
<211> 2477
<212> PRT
<213> Rattus norvegicus
<308> CAA29281
<400> 9260

Met Leu Arg Gly Pro Gly Pro Gly Arg Leu Leu Leu Leu Ala Val Leu 
  1               5                  10                  15
Cys Leu Gly Thr Ser Val Arg Cys Thr Glu Thr Gly Lys Ser Lys Arg 
             20                  25                  30
Gln Ala Gln Gln Ile Val Gln Pro Pro Ser Pro Val Ala Val Ser Gln 
         35                  40                  45
Ser Lys Pro Gly Cys Phe Asp Asn Gly Lys His Tyr Gln Ile Asn Gln 
     50                  55                  60
Gln Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr 
 65                  70                  75                  80
Gly Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Pro Glu Glu 
                 85                  90                  95
Thr Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Lys Val Gly Asp Thr 
             100                105                110
Tyr Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly 
         115                120                125
Ala Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu 
     130                135                140
Gly Gly Gln Ser Tyr Lys Ile Gly Asp Lys Trp Arg Arg Pro His Glu 
 145                150                155                160
Thr Gly Gly Tyr Met Leu Glu Cys Leu Cys Leu Gly Asn Gly Lys Gly 
                 165                170                175
Glu Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala 
             180                185                190
Gly Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly 
         195                200                205
Trp Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Asn Gly Arg Ile 
     210                215                220
Thr Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser 
 225                230                235                240
Tyr Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu 
                 245                250                255
Leu Gln Cys Val Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu 
             260                265                270
Arg His Val Leu Gln Ser Ala Ser Ala Gly Ser Gly Ser Phe Thr Asp 
         275                280                285
Val Arg Thr Ala Ile Tyr Gln Pro Gln Thr His Pro Gln Pro Ala Pro 
     290                295                300
Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
 305                310                315                320
Gln Trp Leu Lys Ser Gln Gly Asp Lys Gln Met Leu Cys Thr Cys Leu 
                 325                330                335
Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
             340                345                350
Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe His Tyr Asn Gly 
         355                360                365
Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
     370                375                380
Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
 385                390                395                400
Cys Thr Asp His Ala Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                 405                410                415
Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Ser Asn Arg Asn Tyr Ser 
             420                425                430
Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
         435                440                445
Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
     450                455                460
Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
 465                470                475                480
Gly Asp Gln Trp Asp Lys Gln His Asp Leu Gly His Met Met Arg Cys 
                 485                490                495
Thr Cys Val Gly Asn Gly Arg Gly Gln Trp Ala Cys Ile Pro Tyr Ser 
             500                505                510
Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
         515                520                525
Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
     530                535                540
Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Ile Asp Arg 
 545                550                555                560
Cys Gln Asp Ser Glu Thr Arg Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                 565                570                575
Glu Lys Phe Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
             580                585                590
Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Gly Thr 
         595                600                605
Thr Gly Pro Val Gln Val Ile Ile Thr Glu Thr Pro Ser Gln Pro Asn 
     610                615                620
Ser His Pro Ile Gln Trp Asn Ala Pro Glu Pro Ser His Ile Thr Lys 
 625                630                635                640
Tyr Ile Leu Arg Trp Arg Pro Lys Thr Ser Thr Gly Arg Trp Lys Glu 
                 645                650                655
Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Thr 
             660                665                670
Pro Gly Val Ile Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
         675                680                685
His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Ser Ala Ser Thr Pro 
     690                695                700
Val Thr Ser Asn Thr Val Thr Gly Glu Thr Ala Pro Phe Ser Pro Val 
 705                710                715                720
Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe Val 
                 725                730                735
Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val Glu 
             740                745                750
Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu Pro 
         755                760                765
Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg Lys 
     770                775                780
Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Glu Gly Lys Gln Ser Leu 
 785                790                795                800
Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp Pro 
                 805                810                815
Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser Arg 
             820                825                830
Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser Val 
         835                840                845
Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser Val 
     850                855                860
Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile Tyr 
 865                870                875                880
Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Phe Ile Gln Gln Glu 
                 885                890                895
Thr Thr Gly Val Pro Arg Ser Asp Asp Val Pro Ala Pro Lys Asp Leu 
             900                905                910
Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr Pro 
         915                920                925
Pro Asn Ser Ala Val Thr Gly Tyr Arg Val Asp Val Leu Pro Val Asn 
     930                935                940
Leu Pro Gly Glu His Gly Gln Arg Leu Pro Val Asn Arg Asn Thr Phe 
 945                950                955                960
Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Leu Phe Lys Val 
                 965                970                975
Phe Ala Val His Gln Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln Gln 
             980                985                990
Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu Thr 
         995                1000                1005
Asp Arg Thr Val Leu Val Thr Trp Thr Pro Pro Arg Ala Arg Ile Ala 
     1010                1015                1020
Gly Tyr Arg Leu Thr Val Gly Leu Thr Arg Gly Gly Gln Pro Lys Gln 
 1025                1030                1035                1040
Tyr Asn Val Gly Pro Met Ala Ser Lys Tyr Pro Leu Arg Asn Leu Gln 
                 1045                1050                1055
Pro Gly Ser Glu Tyr Thr Val Thr Leu Met Ala Val Lys Gly Asn Gln 
             1060                1065                1070
Gln Ser Pro Lys Ala Thr Gly Val Phe Thr Thr Leu Gln Pro Leu Arg 
         1075                1080                1085
Ser Ile Pro Pro Tyr Asn Thr Glu Val Thr Glu Thr Thr Ile Val Ile 
     1090                1095                1100
Thr Trp Thr Pro Ala Pro Arg Ile Gly Phe Lys Leu Gly Val Arg Pro 
 1105                1110                1115                1120
Ser Gln Gly Gly Glu Ala Pro Arg Glu Val Thr Ser Asp Ser Gly Ser 
                 1125                1130                1135
Ile Val Val Ser Gly Leu Thr Pro Gly Val Glu Tyr Thr Tyr Thr Ile 
             1140                1145                1150
Gln Val Leu Arg Asp Gly Gln Glu Arg Asp Ala Pro Ile Val Asn Arg 
         1155                1160                1165
Val Val Thr Pro Leu Ser Pro Pro Thr Asn Leu His Leu Glu Ala Asn 
     1170                1175                1180
Pro Asp Thr Gly Val Leu Thr Val Ser Trp Glu Arg Ser Thr Thr Pro 
 1185                1190                1195                1200
Asp Ile Thr Gly Tyr Arg Ile Thr Thr Thr Pro Thr Asn Gly Gln Gln 
                 1205                1210                1215
Gly Thr Ala Leu Glu Glu Val Val His Ala Asp Gln Ser Ser Cys Thr 
             1220                1225                1230
Phe Glu Asn Arg Asn Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr Thr 
         1235                1240                1245
Val Lys Asp Asp Lys Glu Ser Ala Pro Ile Ser Asp Thr Val Ile Pro 
     1250                1255                1260
Glu Val Pro Gln Leu Thr Asp Leu Ser Phe Val Asp Ile Thr Asp Ser 
 1265                1270                1275                1280
Ser Ile Gly Leu Arg Trp Thr Pro Leu Asn Ser Ser Thr Ile Ile Gly 
                 1285                1290                1295
Tyr Arg Ile Thr Val Val Ala Ala Gly Glu Gly Ile Pro Ile Phe Glu 
             1300                1305                1310
Asp Phe Val Asp Ser Ser Val Gly Tyr Tyr Thr Val Thr Gly Leu Glu 
         1315                1320                1325
Pro Gly Ile Asp Tyr Asp Ile Ser Val Ile Thr Leu Ile Asn Gly Gly 
     1330                1335                1340
Glu Ser Ala Pro Thr Thr Leu Thr Gln Gln Thr Ala Val Pro Pro Pro 
 1345                1350                1355                1360
Thr Asp Leu Arg Phe Thr Asn Ile Gly Pro Asp Thr Met Arg Val Thr 
                 1365                1370                1375
Trp Ala Pro Pro Pro Ser Ile Glu Leu Thr Asn Leu Leu Val Arg Tyr 
             1380                1385                1390
Ser Pro Val Lys Asn Glu Glu Asp Val Ala Glu Leu Ser Ile Ser Pro 
         1395                1400                1405
Ser Asp Asn Ala Val Val Leu Thr Asn Leu Leu Pro Gly Thr Glu Tyr 
     1410                1415                1420
Leu Val Ser Val Ser Ser Val Tyr Glu Gln His Glu Ser Ile Pro Leu 
 1425                1430                1435                1440
Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser Pro Thr Gly Phe Asp Ser 
                 1445                1450                1455
Ser Asp Val Thr Ala Asn Ser Phe Thr Val His Trp Val Ala Pro Arg 
             1460                1465                1470
Ala Pro Ile Thr Gly Tyr Ile Ile Arg His His Ala Glu His Ser Ala 
         1475                1480                1485
Gly Arg Pro Arg Gln Asp Arg Val Pro Pro Ser Arg Asn Ser Ile Thr 
     1490                1495                1500
Leu Thr Asn Leu Asn Pro Gly Thr Glu Tyr Ile Val Thr Ile Ile Ala 
 1505                1510                1515                1520
Val Asn Gly Arg Glu Glu Ser Pro Pro Leu Ile Gly Gln Gln Ser Thr 
                 1525                1530                1535
Val Ser Asp Val Pro Arg Asp Leu Glu Val Ile Ala Ser Thr Pro Thr 
             1540                1545                1550
Ser Leu Leu Ile Ser Trp Glu Pro Pro Ala Val Ser Val Arg Tyr Tyr 
         1555                1560                1565
Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 
     1570                1575                1580
Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Asn Asn Ile Lys Pro 
 1585                1590                1595                1600
Gly Ala Asp Tyr Thr Ile Thr Leu Tyr Ala Val Thr Gly Arg Gly Asp 
                 1605                1610                1615
Ser Pro Ala Ser Ser Lys Pro Val Ser Ile Asn Tyr Gln Thr Glu Ile 
             1620                1625                1630
Asp Lys Pro Ser Gln Met Gln Val Thr Asp Val Gln Asp Asn Ser Ile 
         1635                1640                1645
Ser Val Arg Trp Leu Pro Ser Thr Ser Pro Val Thr Gly Tyr Arg Val 
     1650                1655                1660
Thr Thr Ala Pro Lys Asn Gly Leu Gly Pro Thr Lys Ser Gln Thr Val 
 1665                1670                1675                1680
Ser Pro Asp Gln Thr Glu Met Thr Ile Glu Gly Leu Gln Pro Thr Val 
                 1685                1690                1695
Glu Tyr Val Val Ser Val Tyr Ala Gln Asn Arg Asn Gly Glu Ser Gln 
             1700                1705                1710
Pro Leu Val Gln Thr Ala Val Thr Asn Ile Asp Arg Pro Lys Gly Leu 
         1715                1720                1725
Ala Phe Thr Asp Val Asp Val Asp Ser Ile Lys Ile Ala Trp Glu Ser 
     1730                1735                1740
Pro Gln Gly Gln Val Ser Arg Tyr Arg Val Thr Tyr Ser Ser Pro Glu 
 1745                1750                1755                1760
Asp Gly Ile His Glu Leu Phe Pro Ala Pro Asp Gly Asp Glu Asp Thr 
                 1765                1770                1775
Ala Glu Leu His Gly Leu Arg Pro Gly Ser Glu Tyr Thr Val Ser Val 
             1780                1785                1790
Val Ala Leu His Gly Gly Met Glu Ser Gln Pro Leu Ile Gly Val Gln 
         1795                1800                1805
Ser Thr Ala Ile Pro Ala Pro Thr Asn Leu Lys Phe Thr Gln Val Ser 
     1810                1815                1820
Pro Thr Thr Leu Thr Ala Gln Trp Thr Ala Pro Ser Val Lys Leu Thr 
 1825                1830                1835                1840
Gly Tyr Arg Val Arg Val Thr Pro Lys Glu Lys Thr Gly Pro Met Lys 
                 1845                1850                1855
Glu Ile Asn Leu Ser Pro Asp Ser Thr Ser Val Ile Val Ser Gly Leu 
             1860                1865                1870
Met Val Ala Thr Lys Tyr Glu Val Ser Val Tyr Ala Leu Lys Asp Thr 
         1875                1880                1885
Leu Thr Ser Arg Pro Ala Gln Gly Val Val Thr Thr Leu Glu Asn Val 
     1890                1895                1900
Ser Pro Pro Arg Arg Ala Arg Val Thr Asp Ala Thr Glu Thr Thr Ile 
 1905                1910                1915                1920
Thr Ile Ser Trp Arg Thr Lys Thr Glu Thr Ile Thr Gly Phe Gln Val 
                 1925                1930                1935
Asp Ala Ile Pro Ala Asn Gly Gln Thr Pro Val Gln Arg Thr Ile Ser 
             1940                1945                1950
Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp 
         1955                1960                1965
Tyr Lys Ile His Leu Tyr Thr Leu Asn Asp Asn Ala Arg Ser Ser Pro 
     1970                1975                1980
Val Val Ile Asp Ala Ser Thr Ala Ile Asp Ala Pro Ser Asn Leu Arg 
 1985                1990                1995                2000
Phe Leu Thr Thr Thr Pro Asn Ser Leu Leu Val Ser Trp Gln Ala Pro 
                 2005                2010                2015
Arg Ala Arg Ile Thr Gly Tyr Ile Ile Lys Tyr Glu Lys Pro Gly Ser 
             2020                2025                2030
Pro Pro Arg Glu Val Val Pro Arg Pro Arg Pro Gly Val Thr Glu Ala 
         2035                2040                2045
Thr Ile Thr Gly Leu Glu Pro Gly Thr Glu Tyr Thr Ile Tyr Val Ile 
     2050                2055                2060
Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro Leu Ile Gly Arg Lys Lys 
 2065                2070                2075                2080
Thr Asp Glu Leu Pro Gln Leu Val Thr Leu Pro His Pro Asn Leu His 
                 2085                2090                2095
Gly Pro Glu Ile Leu Asp Val Pro Ser Thr Val Gln Lys Thr Pro Phe 
             2100                2105                2110
Val Thr Asn Pro Gly Tyr Asp Thr Glu Asn Gly Ile Gln Leu Pro Gly 
         2115                2120                2125
Thr Ser His Gln Gln Pro Ser Val Gly Gln Gln Met Ile Phe Glu Glu 
     2130                2135                2140
His Gly Phe Arg Arg Thr Thr Pro Pro Thr Ala Ala Thr Pro Val Arg 
 2145                2150                2155                2160
Leu Arg Pro Arg Pro Tyr Leu Pro Asn Val Asp Glu Glu Val Gln Ile 
                 2165                2170                2175
Gly His Val Pro Arg Gly Asp Val Asp Tyr His Leu Tyr Pro His Val 
             2180                2185                2190
Pro Gly Leu Asn Pro Asn Ala Ser Thr Gly Gln Glu Ala Leu Ser Gln 
         2195                2200                2205
Thr Thr Ile Ser Trp Thr Pro Phe Gln Glu Ser Ser Glu Tyr Ile Ile 
     2210                2215                2220
Ser Cys Gln Pro Val Gly Thr Asp Glu Glu Pro Leu Gln Phe Gln Val 
 2225                2230                2235                2240
Pro Gly Thr Ser Thr Ser Ala Thr Leu Thr Gly Leu Thr Arg Gly Val 
                 2245                2250                2255
Thr Tyr Asn Ile Ile Val Glu Ala Leu His Asn Gln Arg Arg His Lys 
             2260                2265                2270
Val Arg Glu Glu Val Val Thr Val Gly Asn Thr Val Asn Glu Gly Leu 
         2275                2280                2285
Asn Gln Pro Thr Asp Asp Ser Cys Phe Asp Pro Tyr Thr Val Ser His 
     2290                2295                2300
Tyr Ala Val Gly Glu Glu Trp Glu Arg Leu Ser Asp Ser Gly Phe Lys 
 2305                2310                2315                2320
Leu Thr Cys Gln Cys Leu Gly Phe Gly Ser Gly His Phe Arg Cys Asp 
                 2325                2330                2335
Ser Ser Lys Trp Cys His Asp Asn Gly Val Asn Tyr Lys Ile Gly Glu 
             2340                2345                2350
Lys Trp Asp Arg Gln Gly Glu Asn Gly Gln Arg Met Ser Cys Thr Cys 
         2355                2360                2365
Leu Gly Asn Gly Lys Gly Glu Phe Lys Cys Asp Pro His Glu Ala Thr 
     2370                2375                2380
Cys Tyr Asp Asp Gly Lys Thr Tyr His Val Gly Glu Gln Trp Gln Lys 
 2385                2390                2395                2400
Glu Tyr Leu Gly Ala Ile Cys Ser Cys Thr Cys Phe Gly Gly Gln Arg 
                 2405                2410                2415
Gly Trp Arg Cys Asp Asn Cys Arg Arg Pro Gly Ala Ala Glu Pro Ser 
             2420                2425                2430
Pro Asp Gly Thr Thr Gly His Thr Tyr Asn Gln Tyr Thr Gln Arg Tyr 
         2435                2440                2445
His Gln Arg Thr Asn Thr Asn Val Asn Cys Pro Ile Glu Cys Phe Met 
     2450                2455                2460
Pro Leu Asp Val Gln Ala Asp Arg Asp Asp Ser Arg Glu 
 2465                2470                2475



<210> 9262
<211> 2386
<212> PRT
<213> Homo sapiens
<308> P02751
<400> 9262

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
  1               5                  10                  15
Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
             20                  25                  30
Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
         35                  40                  45
Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
     50                  55                  60
Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
 65                  70                  75                  80
Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                 85                  90                  95
Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
             100                105                110
Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
         115                120                125
Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
     130                135                140
Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
 145                150                155                160
Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                 165                170                175
Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
             180                185                190
Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
         195                200                205
Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
     210                215                220
Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
 225                230                235                240
Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                 245                250                255
Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
             260                265                270
His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
         275                280                285
Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
     290                295                300
Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
 305                310                315                320
Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                 325                330                335
Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
             340                345                350
Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
         355                360                365
Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
     370                375                380
Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
 385                390                395                400
Cys Thr Asp His Thr Val Leu Val Gln Thr Gln Gly Gly Asn Ser Asn 
                 405                410                415
Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
             420                425                430
Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
         435                440                445
Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
     450                455                460
Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
 465                470                475                480
Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                 485                490                495
Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
             500                505                510
Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
         515                520                525
Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
     530                535                540
Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
 545                550                555                560
Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                 565                570                575
Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
             580                585                590
Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
         595                600                605
Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
     610                615                620
Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
 625                630                635                640
Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                 645                650                655
Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
             660                665                670
Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
         675                680                685
His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
     690                695                700
Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
 705                710                715                720
Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                 725                730                735
Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
             740                745                750
Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
         755                760                765
Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
     770                775                780
Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
 785                790                795                800
Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                 805                810                815
Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
             820                825                830
Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
         835                840                845
Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
     850                855                860
Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
 865                870                875                880
Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                 885                890                895
Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
             900                905                910
Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
         915                920                925
Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
     930                935                940
Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
 945                950                955                960
Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                 965                970                975
Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
             980                985                990
Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu 
         995                1000                1005
Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala Gln Ile 
     1010                1015                1020
Thr Gly Tyr Arg Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg 
 1025                1030                1035                1040
Gln Tyr Asn Val Gly Pro Ser Val Ser Lys Tyr Pro Leu Arg Asn Leu 
                 1045                1050                1055
Gln Pro Ala Ser Glu Tyr Thr Val Ser Leu Val Ala Ile Lys Gly Asn 
             1060                1065                1070
Gln Glu Ser Pro Lys Ala Thr Gly Val Phe Thr Thr Leu Gln Pro Gly 
         1075                1080                1085
Ser Ser Ile Pro Pro Tyr Asn Thr Glu Val Thr Glu Thr Thr Ile Val 
     1090                1095                1100
Ile Thr Trp Thr Pro Ala Pro Arg Ile Gly Phe Lys Leu Gly Val Arg 
 1105                1110                1115                1120
Pro Ser Gln Gly Gly Glu Ala Pro Arg Glu Val Thr Ser Asp Ser Gly 
                 1125                1130                1135
Ser Ile Val Val Ser Gly Leu Thr Pro Gly Val Glu Tyr Val Tyr Thr 
             1140                1145                1150
Ile Gln Val Leu Arg Asp Gly Gln Glu Arg Asp Ala Pro Ile Val Asn 
         1155                1160                1165
Lys Val Val Thr Pro Leu Ser Pro Pro Thr Asn Leu His Leu Glu Ala 
     1170                1175                1180
Asn Pro Asp Thr Gly Val Leu Thr Val Ser Trp Glu Arg Ser Thr Thr 
 1185                1190                1195                1200
Pro Asp Ile Thr Gly Tyr Arg Ile Thr Thr Thr Pro Thr Asn Gly Gln 
                 1205                1210                1215
Gln Gly Asn Ser Leu Glu Glu Val Val His Ala Asp Gln Ser Ser Cys 
             1220                1225                1230
Thr Phe Asp Asn Leu Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr 
         1235                1240                1245
Thr Val Lys Asp Asp Lys Glu Ser Val Pro Ile Ser Asp Thr Ile Ile 
     1250                1255                1260
Pro Ala Val Pro Pro Pro Thr Asp Leu Arg Phe Thr Asn Ile Gly Pro 
 1265                1270                1275                1280
Asp Thr Met Arg Val Thr Trp Ala Pro Pro Pro Ser Ile Asp Leu Thr 
                 1285                1290                1295
Asn Phe Leu Val Arg Tyr Ser Pro Val Lys Asn Glu Glu Asp Val Ala 
             1300                1305                1310
Glu Leu Ser Ile Ser Pro Ser Asp Asn Ala Val Val Leu Thr Asn Leu 
         1315                1320                1325
Leu Pro Gly Thr Glu Tyr Val Val Ser Val Ser Ser Val Tyr Glu Gln 
     1330                1335                1340
His Glu Ser Thr Pro Leu Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser 
 1345                1350                1355                1360
Pro Thr Gly Ile Asp Phe Ser Asp Ile Thr Ala Asn Ser Phe Thr Val 
                 1365                1370                1375
His Trp Ile Ala Pro Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His 
             1380                1385                1390
His Pro Glu His Phe Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His 
         1395                1400                1405
Ser Arg Asn Ser Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr 
     1410                1415                1420
Val Val Ser Ile Val Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu 
 1425                1430                1435                1440
Ile Gly Gln Gln Ser Thr Val Ser Asp Val Pro Arg Asp Leu Glu Val 
                 1445                1450                1455
Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala 
             1460                1465                1470
Val Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn 
         1475                1480                1485
Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr 
     1490                1495                1500
Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala 
 1505                1510                1515                1520
Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile 
                 1525                1530                1535
Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser Gln Met Gln Val Thr Asp 
             1540                1545                1550
Val Gln Asp Asn Ser Ile Ser Val Lys Trp Leu Pro Ser Ser Ser Pro 
         1555                1560                1565
Val Thr Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly Pro Gly Pro 
     1570                1575                1580
Thr Lys Thr Lys Thr Ala Gly Pro Asp Gln Thr Glu Met Thr Ile Glu 
 1585                1590                1595                1600
Gly Leu Gln Pro Thr Val Glu Tyr Val Val Ser Val Tyr Ala Gln Asn 
                 1605                1610                1615
Pro Ser Gly Glu Ser Gln Pro Leu Val Gln Thr Ala Val Thr Asn Ile 
             1620                1625                1630
Asp Arg Pro Lys Gly Leu Ala Phe Thr Asp Val Asp Val Asp Ser Ile 
         1635                1640                1645
Lys Ile Ala Trp Glu Ser Pro Gln Gly Gln Val Ser Arg Tyr Arg Val 
     1650                1655                1660
Thr Tyr Ser Ser Pro Glu Asp Gly Ile His Glu Leu Phe Pro Ala Pro 
 1665                1670                1675                1680
Asp Gly Glu Glu Asp Thr Ala Glu Leu Gln Gly Leu Arg Pro Gly Ser 
                 1685                1690                1695
Glu Tyr Thr Val Ser Val Val Ala Leu His Asp Asp Met Glu Ser Gln 
             1700                1705                1710
Pro Leu Ile Gly Thr Gln Ser Thr Ala Ile Pro Ala Pro Thr Asp Leu 
         1715                1720                1725
Lys Phe Thr Gln Val Thr Pro Thr Ser Leu Ser Ala Gln Trp Thr Pro 
     1730                1735                1740
Pro Asn Val Gln Leu Thr Gly Tyr Arg Val Arg Val Thr Pro Lys Glu 
 1745                1750                1755                1760
Lys Thr Gly Pro Met Lys Glu Ile Asn Leu Ala Pro Asp Ser Ser Ser 
                 1765                1770                1775
Val Val Val Ser Gly Leu Met Val Ala Thr Lys Tyr Glu Val Ser Val 
             1780                1785                1790
Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg Pro Ala Gln Gly Val Val 
         1795                1800                1805
Thr Thr Leu Glu Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp 
     1810                1815                1820
Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp Arg Thr Lys Thr Glu Thr 
 1825                1830                1835                1840
Ile Thr Gly Phe Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro 
                 1845                1850                1855
Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly 
             1860                1865                1870
Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Asp 
         1875                1880                1885
Asn Ala Arg Ser Ser Pro Val Val Ile Asp Ala Ser Thr Ala Ile Asp 
     1890                1895                1900
Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr Thr Pro Asn Ser Leu Leu 
 1905                1910                1915                1920
Val Ser Trp Gln Pro Pro Arg Ala Arg Ile Thr Gly Tyr Ile Ile Lys 
                 1925                1930                1935
Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu Val Val Pro Arg Pro Arg 
             1940                1945                1950
Pro Gly Val Thr Glu Ala Thr Ile Thr Gly Leu Glu Pro Gly Thr Glu 
         1955                1960                1965
Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro 
     1970                1975                1980
Leu Ile Gly Arg Lys Lys Thr Asp Glu Leu Pro Gln Leu Val Thr Leu 
 1985                1990                1995                2000
Pro His Pro Asn Leu His Gly Pro Glu Ile Leu Asp Val Pro Ser Thr 
                 2005                2010                2015
Val Gln Lys Thr Pro Phe Val Thr His Pro Gly Tyr Asp Thr Gly Asn 
             2020                2025                2030
Gly Ile Gln Leu Pro Gly Thr Ser Gly Gln Gln Pro Ser Val Gly Gln 
         2035                2040                2045
Gln Met Ile Phe Glu Glu His Gly Phe Arg Arg Thr Thr Pro Pro Thr 
     2050                2055                2060
Thr Ala Thr Pro Ile Arg His Arg Pro Arg Pro Tyr Pro Pro Asn Val 
 2065                2070                2075                2080
Gly Glu Glu Ile Gln Ile Gly His Ile Pro Arg Glu Asp Val Asp Tyr 
                 2085                2090                2095
His Leu Tyr Pro His Gly Pro Gly Leu Asn Pro Asn Ala Ser Thr Gly 
             2100                2105                2110
Gln Glu Ala Leu Ser Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln Asp 
         2115                2120                2125
Thr Ser Glu Tyr Ile Ile Ser Cys His Pro Val Gly Thr Asp Glu Glu 
     2130                2135                2140
Pro Leu Gln Phe Arg Val Pro Gly Thr Ser Thr Ser Ala Thr Leu Thr 
 2145                2150                2155                2160
Gly Leu Thr Arg Gly Ala Thr Tyr Asn Ile Ile Val Glu Ala Leu Lys 
                 2165                2170                2175
Asp Gln Gln Arg His Lys Val Arg Glu Glu Val Val Thr Val Gly Asn 
             2180                2185                2190
Ser Val Asn Glu Gly Leu Asn Gln Pro Thr Asp Asp Ser Cys Phe Asp 
         2195                2200                2205
Pro Tyr Thr Val Ser His Tyr Ala Val Gly Asp Glu Trp Glu Arg Met 
     2210                2215                2220
Ser Glu Ser Gly Phe Lys Leu Leu Cys Gln Cys Leu Gly Phe Gly Ser 
 2225                2230                2235                2240
Gly His Phe Arg Cys Asp Ser Ser Arg Trp Cys His Asp Asn Gly Val 
                 2245                2250                2255
Asn Tyr Lys Ile Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly Gln 
             2260                2265                2270
Met Met Ser Cys Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys Cys 
         2275                2280                2285
Asp Pro His Glu Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His Val 
     2290                2295                2300
Gly Glu Gln Trp Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys Thr 
 2305                2310                2315                2320
Cys Phe Gly Gly Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg Pro 
                 2325                2330                2335
Gly Gly Glu Pro Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn Gln 
             2340                2345                2350
Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys Pro 
         2355                2360                2365
Ile Glu Cys Phe Met Pro Leu Asp Val Gln Ala Asp Arg Glu Asp Ser 
     2370                2375                2380
Arg Glu 
 2385



<210> 9263
<211> 988
<212> DNA
<213> Rattus norvegicus
<308> X06150
<400> 9263

caggatggt  gacagcgtg  accgtaccc  ctccctggg  gtggcggcc  aagggatcc  60
cgaccagta  gcggatggg  aggccgcac  tgtgtggca  ctgtacatc  gggacaccc  120
cagccgtac  gcagagtac  aggcgtggt  gcttgggct  ctgcgccag  acgggtgcc  180
ccgggtgct  gacgtggcc  gtggcacag  agtggactc  attatgctg  tggaagagg  240
ctttagcgt  acgagtgtg  atgccagcg  caagatgct  aaatacgca  tgaaggagc  300
ctggaaccg  aggaaggag  cagcctttg  caagtgggt  attgaagaa  ccaactggt  360
gactctgga  aaagatgtg  cagcaggag  tggctttga  gctgtcatc  gccttggga  420
cagttttgc  cacctgccg  acagcaaag  tgaccagag  gagcaccgg  tggcgctaa  480
gaacatcgc  agcatggtg  ggcccgggg  cctgctggt  atcgaccac  gcaactacg  540
ctacatcct  agcacgggc  gtgcacccc  agggaagaa  atctactat  agagtgacc  600
gaccaagga  attacgacg  cagtgctga  agtaaacaa  aaagcccac  tggtaaccc  660
ggactacac  gtgcaggtg  caggtgctg  cagagatgg  gctcctggc  tcagtaagt  720
tcggctctc  tactaccca  actgtttgg  gtctttcac  gagttggtc  aagaagcct  780
tgggggcag  tgccagcac  gcgtcctgg  tgacttcaa  ccttacagg  ccggccagg  840
ctacgttcc  tgctacttc  tccacgtgc  caagaagac  ggctgagcc  ggctccggc  900
cccacccta  gaccatcgc  taccacaga  attgcagag  tgtgggggg  aggcaaaca  960
ggagtcgac  atacagcct  cccttgcc  988



<210> 9264
<211> 292
<212> PRT
<213> Rattus norvegicus
<308> P13255
<400> 9264

Val Asp Ser Val Tyr Arg Thr Arg Ser Leu Gly Val Ala Ala Glu Gly 
  1               5                  10                  15
Ile Pro Asp Gln Tyr Ala Asp Gly Glu Ala Ala Arg Val Trp Gln Leu 
             20                  25                  30
Tyr Ile Gly Asp Thr Arg Ser Arg Thr Ala Glu Tyr Lys Ala Trp Leu 
         35                  40                  45
Leu Gly Leu Leu Arg Gln His Gly Cys His Arg Val Leu Asp Val Ala 
     50                  55                  60
Cys Gly Thr Gly Val Asp Ser Ile Met Leu Val Glu Glu Gly Phe Ser 
 65                  70                  75                  80
Val Thr Ser Val Asp Ala Ser Asp Lys Met Leu Lys Tyr Ala Leu Lys 
                 85                  90                  95
Glu Arg Trp Asn Arg Arg Lys Glu Pro Ala Phe Asp Lys Trp Val Ile 
             100                105                110
Glu Glu Ala Asn Trp Leu Thr Leu Asp Lys Asp Val Pro Ala Gly Asp 
         115                120                125
Gly Phe Asp Ala Val Ile Cys Leu Gly Asn Ser Phe Ala His Leu Pro 
     130                135                140
Asp Ser Lys Gly Asp Gln Ser Glu His Arg Leu Ala Leu Lys Asn Ile 
 145                150                155                160
Ala Ser Met Val Arg Pro Gly Gly Leu Leu Val Ile Asp His Arg Asn 
                 165                170                175
Tyr Asp Tyr Ile Leu Ser Thr Gly Cys Ala Pro Pro Gly Lys Asn Ile 
             180                185                190
Tyr Tyr Lys Ser Asp Leu Thr Lys Asp Ile Thr Thr Ser Val Leu Thr 
         195                200                205
Val Asn Asn Lys Ala His Met Val Thr Leu Asp Tyr Thr Val Gln Val 
     210                215                220
Pro Gly Ala Gly Arg Asp Gly Ala Pro Gly Phe Ser Lys Phe Arg Leu 
 225                230                235                240
Ser Tyr Tyr Pro His Cys Leu Ala Ser Phe Thr Glu Leu Val Gln Glu 
                 245                250                255
Ala Phe Gly Gly Arg Cys Gln His Ser Val Leu Gly Asp Phe Lys Pro 
             260                265                270
Tyr Arg Pro Gly Gln Ala Tyr Val Pro Cys Tyr Phe Ile His Val Leu 
         275                280                285
Lys Lys Thr Gly 
     290



<210> 9265
<211> 744
<212> DNA
<213> Homo sapiens
<308> BG820239
<400> 9265

cacgcgtcg  cacgcgtcg  ccttctgcg  ctggcagat  tgacaagct  gtgtttgtg  60
gggcaaatg  ggaccgggc  tcccagcta  gcgttctaa  tgccatcac  cgcaaattc  120
agctagagc  atctgtgag  ctggtaaac  tgctagatt  ctgccctcc  cagctgacg  180
gcgcggacc  ctactctct  tgctctgat  ctatgacag  tgccctcaa  cgcagggtt  240
atgacctgg  ggaagggct  gaacaaggt  gctcagcac  gatgctcac  atggaggac  300
tgctgcagg  tgccgccgg  tgcaaccct  agtcagtga  caggagctg  tccggtaca  360
gcgcatcca  cgcaagttt  ctgcctgct  ggagccccc  aggtctggg  ccccgtcag  420
atggctgca  gaaaacaca  catccaccc  cgcccccac  taaaggagc  ccaggcaga  480
tgaacagtg  tcctggtga  tgggctggg  gagcctggc  agacctgca  accccactt  540
tcgaaggcg  gctcgtgcc  ccggttcca  cgctcctta  gtgcatact  cagcatctt  600
tcactggca  ccacactcg  cacactgaa  ccctcttcc  ccagcataa  ggagtccac  660
ctgagtacg  cagcgagga  aggcagaga  aggcagtta  gggagcctg  gagggcagg  720
ggagacctg  attggaaac  tttg  744



<210> 9266
<211> 980
<212> PRT
<213> Homo sapiens
<308> Q13608
<400> 9266

Met Ala Leu Ala Val Leu Arg Val Leu Glu Pro Phe Pro Thr Glu Thr 
  1               5                  10                  15
Pro Pro Leu Ala Val Leu Leu Pro Pro Gly Gly Pro Trp Pro Ala Ala 
             20                  25                  30
Glu Leu Gly Leu Val Leu Ala Leu Arg Pro Ala Gly Glu Ser Pro Ala 
         35                  40                  45
Gly Pro Ala Leu Leu Val Ala Ala Leu Glu Gly Pro Asp Ala Gly Thr 
     50                  55                  60
Glu Glu Gln Gly Pro Gly Pro Pro Gln Leu Leu Val Ser Arg Ala Leu 
 65                  70                  75                  80
Leu Arg Leu Leu Ala Leu Gly Ser Gly Ala Trp Val Arg Ala Arg Ala 
                 85                  90                  95
Val Arg Arg Pro Pro Ala Leu Gly Trp Ala Leu Leu Gly Thr Ser Leu 
             100                105                110
Gly Pro Gly Leu Gly Pro Arg Val Gly Pro Leu Leu Val Arg Arg Gly 
         115                120                125
Glu Thr Leu Pro Val Pro Gly Pro Arg Val Leu Glu Thr Arg Pro Ala 
     130                135                140
Leu Gln Gly Leu Leu Gly Pro Gly Thr Arg Leu Ala Val Thr Glu Leu 
 145                150                155                160
Arg Gly Arg Ala Arg Leu Cys Pro Glu Ser Gly Asp Ser Ser Arg Pro 
                 165                170                175
Pro Pro Pro Pro Val Val Ser Ser Phe Ala Val Ser Gly Thr Val Arg 
             180                185                190
Arg Leu Gln Gly Val Leu Gly Gly Thr Gly Asp Ser Leu Gly Val Ser 
         195                200                205
Arg Ser Cys Leu Arg Gly Leu Gly Leu Phe Gln Gly Glu Trp Val Trp 
     210                215                220
Val Ala Gln Ala Arg Glu Ser Ser Asn Thr Ser Gln Pro His Leu Ala 
 225                230                235                240
Arg Val Gln Val Leu Glu Pro Arg Trp Asp Leu Ser Asp Arg Leu Gly 
                 245                250                255
Pro Gly Ser Gly Pro Leu Gly Glu Pro Leu Ala Asp Gly Leu Ala Leu 
             260                265                270
Val Pro Ala Thr Leu Ala Phe Asn Leu Gly Cys Asp Pro Leu Glu Met 
         275                280                285
Gly Glu Leu Arg Ile Gln Arg Tyr Leu Glu Gly Ser Ile Ala Pro Glu 
     290                295                300
Asp Lys Gly Ser Cys Ser Leu Leu Pro Gly Pro Pro Phe Ala Arg Glu 
 305                310                315                320
Leu His Ile Glu Ile Val Ser Ser Pro His Tyr Ser Thr Asn Gly Asn 
                 325                330                335
Tyr Asp Gly Val Leu Tyr Arg His Phe Gln Ile Pro Arg Val Val Gln 
             340                345                350
Glu Gly Asp Val Leu Cys Val Pro Thr Ile Gly Gln Val Glu Ile Leu 
         355                360                365
Glu Gly Ser Pro Glu Lys Leu Pro Arg Trp Arg Glu Met Phe Phe Lys 
     370                375                380
Val Lys Lys Thr Val Gly Glu Ala Pro Asp Gly Pro Ala Ser Ala Tyr 
 385                390                395                400
Leu Ala Asp Thr Thr His Thr Ser Leu Tyr Met Val Gly Ser Thr Leu 
                 405                410                415
Ser Pro Val Pro Trp Leu Pro Ser Glu Glu Ser Thr Leu Trp Ser Ser 
             420                425                430
Leu Ser Pro Pro Gly Leu Glu Ala Leu Val Ser Glu Leu Cys Ala Val 
         435                440                445
Leu Lys Pro Arg Leu Gln Pro Gly Gly Ala Leu Leu Thr Gly Thr Ser 
     450                455                460
Ser Val Leu Leu Arg Gly Pro Pro Gly Cys Gly Lys Thr Thr Val Val 
 465                470                475                480
Ala Ala Ala Cys Ser His Leu Gly Leu His Leu Leu Lys Val Pro Cys 
                 485                490                495
Ser Ser Leu Cys Ala Glu Ser Ser Gly Ala Val Glu Thr Lys Leu Gln 
             500                505                510
Ala Ile Phe Ser Arg Ala Arg Arg Cys Arg Pro Ala Val Leu Leu Leu 
         515                520                525
Thr Ala Val Asp Leu Leu Gly Arg Asp Arg Asp Gly Leu Gly Glu Asp 
     530                535                540
Ala Arg Val Met Ala Val Leu Arg His Leu Leu Leu Asn Glu Asp Pro 
 545                550                555                560
Leu Asn Ser Cys Pro Pro Leu Met Val Val Ala Thr Thr Ser Arg Ala 
                 565                570                575
Gln Asp Leu Pro Ala Asp Val Gln Thr Ala Phe Pro His Glu Leu Glu 
             580                585                590
Val Pro Ala Leu Ser Glu Gly Gln Arg Leu Ser Ile Leu Arg Ala Leu 
         595                600                605
Thr Ala His Leu Pro Leu Gly Gln Glu Val Asn Leu Ala Gln Leu Ala 
     610                615                620
Arg Arg Cys Ala Gly Phe Val Val Gly Asp Leu Tyr Ala Leu Leu Thr 
 625                630                635                640
His Ser Ser Arg Ala Ala Cys Thr Arg Ile Lys Asn Ser Gly Leu Ala 
                 645                650                655
Gly Gly Leu Thr Glu Glu Asp Glu Gly Glu Leu Cys Ala Ala Gly Phe 
             660                665                670
Pro Leu Leu Ala Glu Asp Phe Gly Gln Ala Leu Glu Gln Leu Gln Thr 
         675                680                685
Ala His Ser Gln Ala Val Gly Ala Pro Lys Ile Pro Ser Val Ser Trp 
     690                695                700
His Asp Val Gly Gly Leu Gln Glu Val Lys Lys Glu Ile Leu Glu Thr 
 705                710                715                720
Ile Gln Leu Pro Leu Glu His Pro Glu Leu Leu Ser Leu Gly Leu Arg 
                 725                730                735
Arg Ser Gly Leu Leu Leu His Gly Pro Pro Gly Thr Gly Lys Thr Leu 
             740                745                750
Leu Ala Lys Ala Val Ala Thr Glu Cys Ser Leu Thr Phe Leu Ser Val 
         755                760                765
Lys Gly Pro Glu Leu Ile Asn Met Tyr Val Gly Gln Ser Glu Glu Asn 
     770                775                780
Val Arg Glu Val Phe Ala Arg Ala Arg Ala Ala Ala Pro Cys Ile Ile 
 785                790                795                800
Phe Phe Asp Glu Leu Asp Ser Leu Ala Pro Ser Arg Gly Arg Ser Gly 
                 805                810                815
Asp Ser Gly Gly Val Met Asp Arg Val Val Ser Gln Leu Leu Ala Glu 
             820                825                830
Leu Asp Gly Leu His Ser Thr Gln Asp Val Phe Val Ile Gly Ala Thr 
         835                840                845
Asn Arg Pro Asp Leu Leu Asp Pro Ala Leu Leu Arg Pro Gly Arg Phe 
     850                855                860
Asp Lys Leu Val Phe Val Gly Ala Asn Glu Asp Arg Ala Ser Gln Leu 
 865                870                875                880
Arg Val Leu Ser Ala Ile Thr Arg Lys Phe Lys Leu Glu Pro Ser Val 
                 885                890                895
Ser Leu Val Asn Val Leu Asp Cys Cys Pro Pro Gln Leu Thr Gly Ala 
             900                905                910
Asp Leu Tyr Ser Leu Cys Ser Asp Ala Met Thr Ala Ala Leu Lys Arg 
         915                920                925
Arg Val His Asp Leu Glu Glu Gly Leu Glu Pro Gly Ser Ser Ala Leu 
     930                935                940
Met Leu Thr Met Glu Asp Leu Leu Gln Ala Ala Ala Arg Leu Gln Pro 
 945                950                955                960
Ser Val Ser Glu Gln Glu Leu Leu Arg Tyr Lys Arg Ile Gln Arg Lys 
                 965                970                975
Phe Ala Ala Cys 
             980



<210> 9267
<211> 3170
<212> DNA
<213> Rattus norvegicus
<308> X06564
<400> 9267

ctgaggctg  ggctgtcac  cattctccg  tcagcggtg  acgcagctc  gcagtggct  60
gcaagaaac  attctgcaa  aataatcat  tccagcctg  caattgtct  ctcctcggt  120
cattgctcc  ccgccgtcc  cagtcgctt  caagggaag  cactgaatt  accgcggcc  180
gaacatccc  cccagccgg  agtttacaa  gctgcgaac  aaggatctc  tctggactt  240
gtttttcct  ggaactgca  tttccctgc  ggtagatat  gttcccagc  aaggagaaa  300
cagcgttgg  gagtccaaa  tcttcctgt  tcaagtggc  ggagatgcc  aagataagg  360
catctcctg  ttctccccc  acggggaga  actgagccc  aaccagcag  ggatctcag  420
ggtgtggaa  gatgatgac  cctctaccc  caccatcta  aacgccaac  ttgatgatg  480
cggcattta  aagtgcgtg  tcaccgctg  agacggcac  cagtccgag  ccactgtca  540
tgtgaagat  ttccagaag  tcatgttca  gaatgcgcc  accccacag  agtttaagg  600
aggggaaga  gctgtgatt  tctgtgatg  ggtcagctc  ctgccccca  ccatcatct  660
gaaacacaa  ggccgagat  tcatcctga  aaaagatgt  cggttcata  tcctatcca  720
caactacct  cagatccga  gcatcaaga  aacagatga  ggcacttac  gctgtgaag  780
caggatcct  gcccggggg  agatcaact  caaggacat  caggtcatt  tgaatgtac  840
acccactgt  caggccaga  agagcatcg  gaatgccac  gccaacctg  gccagtctg  900
caccctggt  tgtgatgcc  atggcttcc  agagcccac  atgagctgg  caaaggatg  960
ggaacccat  gagaatgag  aggaagatg  cgagaagca  atcttcagt  acgacagtt  1020
ggagctgac  atcaggaat  tggacaaaa  tgacgaagc  gaatacgtc  gcatcgctg  1080
gaacaaggc  ggcgagcag  atgcctcca  ccacctcaa  gtcttcgca  agcccaaaa  1140
cacctatgt  gagaatcag  cagccatgg  actagagga  caagtcact  tgacatgtg  1200
agcctccgg  gaccccatt  cttccatca  ctggagaac  tccacccga  acatcagca  1260
tgaagaaaa  gcatcgtgg  ctcgaccag  gaagcaaga  actctagat  ggcacatgg  1320
ggtacgcag  catgctcgt  tgtcctccc  gaccctgaa  agcatccag  acacagatg  1380
tggagaata  atctgcact  ccagcaaca  catcggcca  gactcccag  ccatgtacc  1440
tgaagttca  tatgctccc  agctccagg  ccctgtagc  gtgtacact  gggaaggga  1500
ccaggtgaa  atcacctgt  aggtctttg  ctacccaag  gccacaatc  cctggttcc  1560
agatggcca  ttgctgcca  gctccaact  cagcaatat  aagatctac  acaccccat  1620
tgcgagcta  ctggaggta  cccctgatt  cgaaaatga  tttggaaac  acaactgca  1680
agcggtgaa  cgtattgga  aggagtcct  ggaattcat  ctggttcaa  cagatacac  1740
atcttcccc  tccatcgac  gggtggaac  atactccag  acagcacag  tacaatttg  1800
tgagccaga  gccacaggt  gagttccca  cctcaaata  aaggctgag  ggaagtcgc  1860
gggtgaaga  gcatggcat  ccaagtggt  tgatgccaa  gaagccaac  tggaaggga  1920
tgtcaccat  atgggcctg  agcctgaga  aaggtacgc  gtacgactg  cggccctca  1980
cggcaaggg  ctgggcgag  tcagtgcag  cactgagtt  aagacacag  cagtccggg  2040
acccagcgc  cccaagctg  aagggcaga  gggagagga  gggaactcc  tcaaggtga  2100
cctgatcaa  caggatgac  gcggctccc  catcagaca  tatctggtc  agtacagag  2160
gctcgcctc  gagtggaaa  cagagatca  gctcccgtc  ggcagtgac  acgtcatgc  2220
caagtccct  gactggaac  ccgagtacg  agtatatgt  gtagctgag  accagcaag  2280
aaaatccaa  gcagctcac  tcgtgttca  gacttcagc  cagcccacg  ccatcccag  2340
caatggcag  cccactgca  gcctgagca  aggcgccat  gtgggcatc  tcattgtca  2400
tttcgtcct  ctcctggtg  tcatggaca  cacctgcta  ttcctgaac  agtgtggcc  2460
gctcatgtg  atcgctgtt  acctgtgcg  caaagcggg  cccggagcc  agggcaaag  2520
catggagga  ggcaaggct  ctttctcga  agatgagtc  aaagaaccc  ttgtagagg  2580
ccgaacgga  gaggaacgg  ctccaaacc  tgacggagg  aagcacaca  agcccaacg  2640
gaccacacc  ctgacagag  ccgagaagg  tcctgtaga  acaaagtcc  agccccagg  2700
gtcagaagc  aagccagcg  caactgaag  caagacggt  cccaatgaa  ccacacaaa  2760
gaaagagaa  gagagcaaa  catgatggg  accagcaaa  agcaaagat  aaaataaca  2820
attgacaca  cggcttcac  agagcatcc  caaataacc  cccccccct  tctctctct  2880
tcacacaca  acacacaca  acacacaca  acacacaca  acactcact  ctctagtgt  2940
ttttgcctt  taaaaaaac  acaaaaaac  gataaacat  ggattgcct  tttgtaggt  3000
tctagaaag  gctcctttg  tgcacactc  cttgttaag  aaaaaaaag  gacaaaaag  3060
ttaaaccca  agccaaact  ggacactcc  ttccctgaa  ccatttaaa  atcaaacaa  3120
agggcccca  attaagaat  taggaagct  agactgaag  gaaaaacaag  3170



<210> 9268
<211> 858
<212> PRT
<213> Rattus norvegicus
<308> P13596
<400> 9268

Met Leu Arg Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
  1               5                  10                  15
Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
             20                  25                  30
Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
         35                  40                  45
Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Ser Pro 
     50                  55                  60
Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Asp Ser Ser Thr 
 65                  70                  75                  80
Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                 85                  90                  95
Val Val Thr Ala Glu Asp Gly Thr Gln Ser Glu Ala Thr Val Asn Val 
             100                105                110
Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
         115                120                125
Phe Lys Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
     130                135                140
Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
 145                150                155                160
Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                 165                170                175
Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
             180                185                190
Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
         195                200                205
Asn Val Pro Pro Thr Val Gln Ala Arg Gln Ser Ile Val Asn Ala Thr 
     210                215                220
Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Asp Gly Phe 
 225                230                235                240
Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Pro Ile Glu Asn 
                 245                250                255
Glu Glu Glu Asp Asp Glu Lys His Ile Phe Ser Asp Asp Ser Ser Glu 
             260                265                270
Leu Thr Ile Arg Asn Val Asp Lys Asn Asp Glu Ala Glu Tyr Val Cys 
         275                280                285
Ile Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Ser Ile His Leu Lys 
     290                295                300
Val Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met 
 305                310                315                320
Glu Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro 
                 325                330                335
Ile Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu 
             340                345                350
Glu Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly 
         355                360                365
His Met Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys 
     370                375                380
Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser Asn 
 385                390                395                400
Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala 
                 405                410                415
Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln 
             420                425                430
Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser 
         435                440                445
Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile 
     450                455                460
Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp 
 465                470                475                480
Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile 
                 485                490                495
Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser 
             500                505                510
Ser Pro Ser Ile Asp Arg Val Glu Pro Tyr Ser Ser Thr Ala Gln Val 
         515                520                525
Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr 
     530                535                540
Lys Ala Glu Trp Lys Ser Leu Gly Glu Glu Ala Trp His Ser Lys Trp 
 545                550                555                560
Tyr Asp Ala Lys Glu Ala Asn Met Glu Gly Ile Val Thr Ile Met Gly 
                 565                570                575
Leu Lys Pro Glu Thr Arg Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly 
             580                585                590
Lys Gly Leu Gly Glu Ile Ser Ala Ala Thr Glu Phe Lys Thr Gln Pro 
         595                600                605
Val Arg Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 
     610                615                620
Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 
 625                630                635                640
Pro Ile Arg His Tyr Leu Val Lys Tyr Arg Ala Leu Ala Ser Glu Trp 
                 645                650                655
Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 
             660                665                670
Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 
         675                680                685
Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 
     690                695                700
Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ala Gly Leu Ser 
 705                710                715                720
Thr Gly Ala Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu 
                 725                730                735
Val Val Met Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Leu 
             740                745                750
Met Cys Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys 
         755                760                765
Gly Lys Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser 
     770                775                780
Lys Glu Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn 
 785                790                795                800
His Asp Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr 
                 805                810                815
Glu Pro Glu Lys Gly Pro Val Glu Thr Lys Ser Glu Pro Gln Glu Ser 
             820                825                830
Glu Ala Lys Pro Ala Pro Thr Glu Val Lys Thr Val Pro Asn Glu Ala 
         835                840                845
Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
     850                855



<210> 9269
<211> 2633
<212> DNA
<213> Homo sapiens
<308> U63041
<400> 9269

ccgcggcaa  aacatccct  ccagccagc  gattacaat  ctgcaaact  aggatctca  60
ctggacttt  tttttcctg  gaactgcag  ttctctgca  gtggatatt  ttcccagcc  120
gggggagat  agcgttgga  agtccaaat  cttcttatg  caagtggca  gagatgcca  180
agataaaga  atctcctgg  tctccccca  tggagaaaa  ctcacccca  accagcagc  240
gatctcagt  gtgtggaat  atgattcct  ctccaccct  accatctat  acgccaaca  300
cgacgacgc  ggcatttac  agtgtgtgg  tacaggcga  gatggcagt  agtcagagg  360
caccgtcaa  gtgaagatc  ttcagaagc  catgttcaa  aatgcgcca  ccccacagg  420
gttccggga  ggggaagat  ccgtgattg  gtgtgatgt  gtcagctcc  tcccaccaa  480
catcatctg  aaacacaaa  gccgagatg  catcctgaa  aaagatgtc  gattcatag  540
cctgtccaa  aactacctg  agatccggg  catcaagaa  acagatgag  gcacttatc  600
ctgtgaggg  agaatcctg  cacgggggg  gatcaactt  aaggacatt  aggtcattg  660
gaatgtgcc  cctaccatc  gggccaggc  gaatattgt  aatgccacc  ccaacctcg  720
ccagtccgt  accctggtg  gcgatgccg  acggttccc  gagcccacc  tgagctgga  780
aaaggatgg  gaacagata  agcaagagg  agacgatga  aagtacatc  tcagcgacg  840
tagttccca  ctgaccatc  aaaaggtgg  taagaacga  gaggctgag  acatctgca  900
tgctgagaa  aaggctggc  agcaggatg  gaccatcca  ctcaaagtc  ttgcaaaac  960
caaaatcac  tatgtagag  accagactg  catggaatt  gaggagcag  tcactctta  1020
ctgtgaagc  tccggagac  ccattccct  catcacctg  aggacttct  cccggaaca  1080
cagcagcga  gaaaagact  tggatgggc  catggtggt  cgtagccat  cccgtgtgt  1140
gtcgctgac  ctgaagagc  tccagtaca  tgatgccgg  gagtacatc  gcaccgcca  1200
caacaccat  ggccaggac  cccagtcca  gtaccttga  gtgcaatat  ccccaaagc  1260
acagggccc  gtggctgtg  acacttggg  ggggaacca  gtgaacatc  cctgcgagg  1320
atttgccta  cccagtgcc  cgatctcat  gtttcggga  ggccagctg  tgccaagct  1380
caattacag  aatatcaag  tctacaaca  cccctctgc  agctatctg  aggtgaccc  1440
agactctga  aatgatttt  ggaactaca  ctgtactgc  gtgaaccgc  ttgggcagg  1500
gtccttcga  ttcatcctt  ttcaagcag  caccccctc  tcaccatcc  tcgaccagg  1560
ggagccata  tccagcaca  cccaggtgc  gtttgatga  ccagaggcc  caggtgggg  1620
gcccatcct  aaatacaaa  ctgagtgga  agcagtggg  gaagaagta  ggcattcca  1680
gtggtatga  gccaaggaa  ccagcatgg  gggcatcgt  accatcgtg  gcctgaagc  1740
cgaaacaac  tacgccgta  ggctggcgg  gctcaatgg  aaagggctg  gtgagatca  1800
cgcggcctc  gagttcaag  cgcagccag  ccaagggga  cccagtgca  ctaagctcg  1860
agggcagat  ggagaggat  gaaactcta  taaagtgaa  ctgatcaag  aggatgacg  1920
cggctcccc  atcagacac  atctggtca  gtaccgagc  ctctcctcc  agtggaaac  1980
agagatcag  ctcccgtct  gcagtgacc  cgtcatgct  aagtccctg  actggaatg  2040
tgagtatga  gtctacgtg  tggctgaga  ccagcaagg  aaatccaag  cggctcatt  2100
tgtgttcag  acctcggcc  agcccacag  catcccagc  aacggcagc  ccacctcag  2160
cctgagcac  ggggccatc  tgggcatcc  catcgtcat  ttcgtcctg  tcctggtgg  2220
tgtggacat  acctgctac  tcctgaaca  gtgtggcct  ttcatgtgc  ttgcggtca  2280
cctgtgtgg  aaagccggg  ccggggcca  gggcaagga  atggaggag  gcaaggccg  2340
cttctcgaa  gatgagtcc  aggagccca  cgtggaggt  cgaacggag  aggagagga  2400
cccaaacca  gatggaggg  aacacacag  gcccaacga  accacgcca  tgacggagc  2460
cgagaaggg  cccgtagaa  caaagccag  gtgccagga  acagaaacg  agccagcgc  2520
agccgaagt  aagacggtc  ccaatgacg  cacacagac  aaggagaac  agagcaaag  2580
atgatgggt  aagagaacc  agcaaagat  aaaataaaa  gtgacacag  agc  2633



<210> 9270
<211> 761
<212> PRT
<213> Homo sapiens
<308> P13592
<400> 9270

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
  1               5                  10                  15
Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
             20                  25                  30
Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
         35                  40                  45
Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
     50                  55                  60
Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
 65                  70                  75                  80
Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                 85                  90                  95
Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
             100                105                110
Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
         115                120                125
Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
     130                135                140
Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
 145                150                155                160
Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                 165                170                175
Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
             180                185                190
Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
         195                200                205
Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
     210                215                220
Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
 225                230                235                240
Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                 245                250                255
Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
             260                265                270
Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
         275                280                285
Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
     290                295                300
Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
 305                310                315                320
Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                 325                330                335
Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
             340                345                350
Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
         355                360                365
Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
     370                375                380
Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
 385                390                395                400
Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                 405                410                415
Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
             420                425                430
Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
         435                440                445
Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
     450                455                460
Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
 465                470                475                480
Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                 485                490                495
Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
             500                505                510
Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
         515                520                525
Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
     530                535                540
Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
 545                550                555                560
Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                 565                570                575
Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
             580                585                590
Phe Lys Thr Gln Pro Val His Ser Pro Pro Pro Pro Ala Ser Ala Ser 
         595                600                605
Ser Ser Thr Pro Val Pro Leu Ser Pro Pro Asp Thr Thr Trp Pro Leu 
     610                615                620
Pro Ala Leu Ala Thr Thr Glu Pro Ala Lys Gly Glu Pro Ser Ala Pro 
 625                630                635                640
Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn 
                 645                650                655
Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val 
             660                665                670
Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro 
         675                680                685
Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu 
     690                695                700
Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala 
 705                710                715                720
Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala 
                 725                730                735
Thr Leu Gly Gly Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe 
             740                745                750
Ser Ala Val Thr Leu Leu Leu Leu Cys 
         755                760



<210> 9271
<211> 2310
<212> DNA
<213> Rattus norvegicus
<308> X06655
<400> 9271

aattcggag  tccgggtgg  caaggagcc  cttggcttc  tgaaggtgc  gcagtgggt  60
tttgccatc  tcgcctttg  tacgtgtgg  agctacacc  gggagcttc  gctgagcgt  120
gagtgtgcc  acaagacgg  gagtgccct  aacatcgaa  ttgaattcg  gtacccctt  180
aggctgcac  aagtgtact  tgatgcacc  tcctgcgtc  aagggggca  taccaagat  240
ttcctggtt  gggactact  ctcgtcggc  gaattcttt  tcaccgtgg  tgtgtttgc  300
ttcctctac  ccatggggg  cctggccac  tacatcttc  tgcagaaca  gtaccgaga  360
aacaacaaa  ggcctatga  ggactttct  gctacagcc  tgttcgctt  catgtggct  420
gttagttca  cagcctggg  caaaggcct  tccgatgtg  agatggcca  ggacccaga  480
aacattatc  aggagatgc  catgtgccg  cagacaggg  acacatgca  ggaactgag  540
gaccctgtg  cttcaggac  caacacctc  gtggtgttt  gcttcctga  cctggtgct  600
tgggttggc  acttatggt  cgtgttcaa  gagacaggc  gggcagccc  attcatgcg  660
gcacctcca  gcgccccgg  aaagcaacc  gcacctggc  atgcctacg  cgatgcggg  720
tacgggcag  gccccggag  ctatgggcc  caggactcc  acgggcctc  gggtggtta  780
caacccgat  acgggcagc  agccagcgg  ggcggtggc  acgggcctc  gggcgacta  840
gggcagcaa  gctatggcc  acagggtgc  cccacctcc  tctccaatc  gatgtaatc  900
ggtcagtga  gtccatgaa  atcccacgg  tgggcaata  ctcaagaga  ggcctgccc  960
ccttttccc  tccccatat  ctaggtctc  acccctcaa  ccaggagac  ctaactgtc  1020
ttgctgttt  tatatatat  tattatata  aaatatcta  ttatctgtc  gagccctac  1080
ttcacccac  tctccatgc  ctagaggcc  agtcctgaa  gggctcctc  ccaaccctg  1140
ccttgcatt  ctcagcccc  atctgttcc  cagccctgt  ccttgaggt  aggggctct  1200
gaaagggga  aggaaggga  ccagacctt  gctgcatgg  gtgggttgg  gtgactttc  1260
ctccttcct  ctctccctc  gcccctcct  actctggcc  tggtcctcc  gcatcacct  1320
aacttcaga  gctctcgaa  ggaaatctg  ccccaagag  agagcagta  actgagtgg  1380
ggaggcttg  gtgaaacgg  cagagagga  ataacctct  tagagagag  actagtcag  1440
caagagttg  attccagac  tactggatg  gcagtctaa  aggaaagtg  tatcctacc  1500
cattctgca  tggggcttt  agtgaccag  gagagtggt  ctaggaggg  tgtggctta  1560
acacagcgg  ctccagagt  ggcaggttt  ggttggatc  agcatctct  gaaggggtg  1620
gtcttggaa  attcaggag  ttgagcttg  ttccaaaga  cttgagcaa  ggtagaagt  1680
ggttcaggg  tgatctaag  ttgagatga  gtcctgctt  ggattccag  caagcatat  1740
aagagatgt  tggtggtct  agaagagga  acccattct  taatggggc  gagaagaaa  1800
cacgttttc  attgagtgg  gtttgaggg  gtgcaggag  ccatggtta  gagctatga  1860
gtgagtttt  ctaaaagca  gagggcgta  tcctggccc  tgcgaattg  ggtaatgtg  1920
ggaaagcca  gtattgtgg  ttggattgt  aacaaaatg  cccttgcgg  ctccctcaa  1980
agacagcta  atcatcaga  gacagagtc  gcaggtctg  agggctggt  taccttctc  2040
cccctttct  tgccctctc  ctccacact  ccgtctgtc  cggaatact  ggaggctgg  2100
tctggagcc  cgatcctgt  ccctctgct  tgtctgtga  gttggtagt  cctgtgatc  2160
tgtgttgcc  ttttgtctg  ctgtggtcc  tccctcttc  ctccagacc  cctactttc  2220
tgtgccctt  ggtattgtt  gaagacccc  tccccgagg  agagcaaat  tgagaaatt  2280
ccctccccc  aataaactc  tcaactacct  2310



<210> 9272
<211> 307
<212> PRT
<213> Rattus norvegicus
<308> P07825
<400> 9272

Met Asp Val Val Asn Gln Leu Val Ala Gly Gly Gln Phe Arg Val Val 
  1               5                  10                  15
Lys Glu Pro Leu Gly Phe Val Lys Val Leu Gln Trp Val Phe Ala Ile 
             20                  25                  30
Phe Ala Phe Ala Thr Cys Gly Ser Tyr Thr Gly Glu Leu Arg Leu Ser 
         35                  40                  45
Val Glu Cys Ala Asn Lys Thr Glu Ser Ala Leu Asn Ile Glu Val Glu 
     50                  55                  60
Phe Glu Tyr Pro Phe Arg Leu His Gln Val Tyr Phe Asp Ala Pro Ser 
 65                  70                  75                  80
Cys Val Lys Gly Gly Thr Thr Lys Ile Phe Leu Val Gly Asp Tyr Ser 
                 85                  90                  95
Ser Ser Ala Glu Phe Phe Val Thr Val Ala Val Phe Ala Phe Leu Tyr 
             100                105                110
Ser Met Gly Ala Leu Ala Thr Tyr Ile Phe Leu Gln Asn Lys Tyr Arg 
         115                120                125
Glu Asn Asn Lys Gly Pro Met Met Asp Phe Leu Ala Thr Ala Val Phe 
     130                135                140
Ala Phe Met Trp Leu Val Ser Ser Ser Ala Trp Ala Lys Gly Leu Ser 
 145                150                155                160
Asp Val Lys Met Ala Thr Asp Pro Glu Asn Ile Ile Lys Glu Met Pro 
                 165                170                175
Met Cys Arg Gln Thr Gly Asn Thr Cys Lys Glu Leu Arg Asp Pro Val 
             180                185                190
Thr Ser Gly Leu Asn Thr Ser Val Val Phe Gly Phe Leu Asn Leu Val 
         195                200                205
Leu Trp Val Gly Asn Leu Trp Phe Val Phe Lys Glu Thr Gly Trp Ala 
     210                215                220
Ala Pro Phe Met Arg Ala Pro Pro Gly Ala Pro Glu Lys Gln Pro Ala 
 225                230                235                240
Pro Gly Asp Ala Tyr Gly Asp Ala Gly Tyr Gly Gln Gly Pro Gly Gly 
                 245                250                255
Tyr Gly Pro Gln Asp Ser Tyr Gly Pro Gln Gly Gly Tyr Gln Pro Asp 
             260                265                270
Tyr Gly Gln Pro Ala Ser Gly Gly Gly Gly Tyr Gly Pro Gln Gly Asp 
         275                280                285
Tyr Gly Gln Gln Gly Tyr Gly Gln Gln Gly Ala Pro Thr Ser Phe Ser 
     290                295                300
Asn Gln Met 
 305



<210> 9273
<211> 31737
<212> DNA
<213> Homo sapiens
<308> AF196779
<400> 9273

gatcaggac  cctcttcca  gctgaagct  ctgcggcgg  tgctggcct  ggagacagc  60
ggggacact  aagagagca  gggatcgga  gcagcccgc  gtggggaca  ggcaccccc  120
gacagtcct  ccaccaccc  ctcctcctc  tccatcaga  tgtcctcca  ccccaggtg  180
aaggggtct  ccaggtccc  caggtggtc  ctgggaaag  gcaggtcca  aagggcatc  240
gagggcggt  cagggggct  ctgatgggg  gcattctgg  caggtcccc  ccctacatg  300
aacgttgct  cgcctggcc  gccctcctc  tcaatgtcc  gctgctctg  cttgaggct  360
tcagaagcc  aagtcgtgg  caaggaaag  agccctgga  tgggaggta  tggcaggcc  420
tggatctgg  cctgcagtt  tagttcctg  aaaaaatag  ggttgggtg  aggataagt  480
gggttcaga  tccctcaga  gcagaggag  ataaaggtt  aaaagggta  gttccctgg  540
ttggaattc  gcttctgct  ctcactagt  ccaaaactt  aggcaaggt  cttaacatc  600
ctgaagctt  agagtcgca  actgtaaag  gggtatata  taatggccc  taggctggg  660
gcggtggct  acgcctgta  tcactttgg  aggccgagg  aggtggatc  cctgaggtc  720
ggagttcga  accagcttg  ccaacatgg  gaaacccca  ctctactaa  aatacaaaa  780
ttagctggg  gtggtggtg  atgcctata  tcctagcta  tcaggaggc  gagacagga  840
aattgcttg  acccgggag  cggaggttg  ggtgagccg  gattgcgcc  ttgcactcc  900
gcctgggca  cgagcgaaa  tccatctca  aaataaata  ataaataaa  aaataaaat  960
atggcccct  tctcataga  ttctgagga  tgaataagt  agtggatat  aagctcttg  1020
cacagtaca  agcacaaga  aaatgctat  tacattagc  atattatta  ccttgttaa  1080
attatgatt  ttatttatc  ttatcacta  catcatcgt  tgatctggg  agcccaggg  1140
tcccccaag  atgccagga  gggaaaccc  ggcctgctc  ctctctgcc  ccacctgca  1200
gaagctctc  ccctcttcc  ccaccacca  ctcctcttt  caaacctga  ttcggagct  1260
caggctgcg  ttggcctgc  ccagggatc  ctgccggct  tccaggtct  tggagcgct  1320
ctgctcctt  tgcagcttg  ggatataat  cacagaggc  ttcaggatg  tgcccttgt  1380
ccagcgcat  tccctgtgg  gcccaagtg  gaggcaagc  ggaaatgcc  catgaggag  1440
ttctcagga  ctgaggcgg  gattgcacc  ggtgggagc  tcccaccac  tgcttagaa  1500
ttgaggctg  ggtctttca  aggtatgga  tatccagag  aaaacttcc  gcctggaat  1560
ttacaatgg  gccccatca  actccaaac  ctggaagcc  tctctgacc  gacccctta  1620
gattcctct  ttccctatg  ccctccgat  gatctcact  cagccacat  ggtctctca  1680
tgctcctag  atatggaaa  ccactccca  ctcagggca  caatcccag  cgtgccctc  1740
gccttgaat  ctcttaccc  cagacaccc  tgcggctcc  cgccttgcc  ccttaggct  1800
tttattcaa  cgtttcctt  tcagttggg  cctgccctg  cctcacctt  cttatccca  1860
actaaccct  cccaacatt  tcccatttt  cttccagtc  ttattcttc  cataacact  1920
atcataatg  atctcatgg  tgtttactt  tttactatt  gtctgcccc  actaaaaca  1980
cagtttcat  aggtctgtt  tgttccctc  ggtatcttt  gggcctaat  tggtacctg  2040
cacaaacca  aggttcaaa  aataaatct  tctcttttc  ttttttttt  cggggcggt  2100
ggggatgga  tctcgctct  tcacccagg  tggagagca  tggcacaat  tcggctcac  2160
acaacctcc  cttcttggg  tcaagcgat  ctcctgcct  agccttctg  gtagctgag  2220
tgacaggcc  acgccacca  gcccagcta  ttttttttg  attttttgt  gagatgggg  2280
ttcaccatg  tggccaggc  ggtctcaaa  tcctgacct  aggtgatcc  cccgtctcg  2340
cctccccaa  tgctgggat  acaggtgcc  accaccacg  cccgctaat  tttatattt  2400
taatagaaa  ggggtttca  catgttggc  agaatggtc  caatctcct  accttgtga  2460
ccacccgcc  cagcctccc  aagtgctgg  attacaggc  tgagccact  cgcccggcc  2520
tcttttttt  tgtttgttt  tgagacaaa  tcttgctct  tcacccagg  tggagtgca  2580
tggcaccat  ttggctcac  gcaacctcc  cctcccggg  tcaagtgat  ctcctgcct  2640
agcatcccg  gtagcgggg  ttacaggtg  gtgccacca  gcccagcta  atttttttt  2700
tttttagtg  agacagggt  tcaccatgt  ggccttcac  tcctgacct  gtgatccgc  2760
tgccttggc  tcccaaagt  ccaggatta  aagtgtgag  cactgcacc  ggctaattt  2820
tgtattttt  agtagagac  gggtttcat  atgttggcc  ggctagtct  aaactcctg  2880
ccttaggtg  tcgaccccg  cttggcctc  caaagtgct  ggattacag  catgagcca  2940
cacacccgg  caataaata  atcttgaat  aataaagga  gtaccattg  accactgca  3000
tccagcctg  gtgacagcg  gagactcca  ctcaaaaaa  agaaaaaaa  aaaggaagt  3060
ctaagtgaa  agaaaagta  gtgcatata  cctacgggg  ccagatggg  cacacagac  3120
ataacatta  gtgcctaaa  ttttaggtg  tgacatagt  agggtctgc  accctgctc  3180
ggctgagaa  gaaccagac  gaggagaaa  gcctgggcc  agactgcct  gtgagccca  3240
caaggcaca  ttttagtag  atgggacgc  tgccccacc  cccgctggc  tgagggtcc  3300
agcccagac  cacgggtca  tggacttag  gatgagagt  cccagttcc  tgatcctgt  3360
gttaatgtt  aatcgcctg  gacgctcaa  tttggagag  ggaggagag  aagaaagag  3420
gggagaaag  gttgtcaat  agccaaaaa  ggaagagac  gaaagtagg  agttgggag  3480
ctgttgcag  gaaggagtt  cccatgggg  gccaggact  ggggtgagg  aggcctgca  3540
agcacccgg  caatgcaca  gctctctgg  ttacttagg  tgtgattgt  tttcttctg  3600
cgttccttc  aaagggcct  tgcctcggt  tctggaaaa  agtggagtg  tcagggcct  3660
tgagcacag  aaggcaaga  acacatgca  atactaagg  agggtttgg  agccaaaag  3720
aggggaaat  cctttttta  aaagtgcct  ctttttact  ttttaagcc  tggtgatag  3780
ctggttgtt  aatccaaga  gagaggaac  gaagtgggg  gaaagcaag  ccacaagcc  3840
tagggggaa  ggggacaaa  agcctccat  tccatatgt  caaaccatt  ccctcagaa  3900
caggcccat  tctagacct  gtaggcaca  ggctcacct  gggtaaagt  tagggccat  3960
gggccaaga  cctatcacc  accagagat  tcccgtttg  tgttgggca  ctcagctgg  4020
caggagttg  tgacagtga  ggctggtgt  gccacgcct  gactactgt  cacatcaag  4080
agattccct  acacaggca  ctgggggca  agagggcag  gaaccacca  ttgggaaca  4140
acccaggct  ggctcctcc  cagaaccag  ttcctgagc  tccacatat  ccaaagatg  4200
ggcaccctc  aatgcaagg  ctggctgac  cagcaccag  acccttgct  ctccttcaa  4260
gcaaattca  atggcgacc  aacagggga  gacagagca  actggacct  ccttgcttc  4320
ctgggagac  ggagcctgc  tggcctgct  atcacttcc  ccagtccct  atatccctc  4380
gtgacctct  aagcccctt  cccaaaccc  ggggctggc  ctgagaaga  atgctggaa  4440
accaccctt  tcaggtctt  gtcggctct  atgggacat  ccagtccgt  agctcctcc  4500
agcacaaca  tccaatcca  cattcttgg  acactccaa  ccaatcttc  ccgaccttg  4560
taaattgtc  tgacaacat  ctatccaaa  tctggcctt  tggagaatt  caacctaat  4620
tccagtctt  cactctgat  aagttgtac  atcttccac  ctgatcaag  tgtaccatc  4680
tccacatca  ggtctcctg  tgctgtgga  caaggtcct  actccagta  cttcctgca  4740
attctgttc  ctcaggaga  tcttatcca  ctattcaat  agcactgct  tatgtcagc  4800
tagtttttt  ttttttcct  tccttcaca  tttcctgga  atactccag  ggagcacgt  4860
aatcttaag  atacccagg  ccaggtgca  tggctcacg  ctgtaatcc  agcactttg  4920
gaggccgag  cgggcggat  acttgaggt  aggagttcg  gaccagcct  gccaacatg  4980
tgaaactcc  tctctacta  aaatacaaa  caacaaaaa  aattagccg  gcatggtgg  5040
ctgcacttg  agtcccagc  acttgagag  ctgaaacag  agagttgct  gaacccagg  5100
ggtagaggt  gcagtgagc  aagatcaca  cactgcact  cagcctggg  aacagagca  5160
gactctatc  caaaataaa  aaataaata  ataaataaa  aaataaata  aaataaaat  5220
aagtatatc  aaatcccac  tcttcatga  ttttaatct  ttttttttt  ttttttttt  5280
tttgagacg  agtatcgtt  tgtcaccca  gctggaggg  agtggcgca  tctcggctc  5340
ctgcaagct  tgcctcccg  gttcacgcc  ttctcctgc  tcagcctcc  gagtagctg  5400
gactacagg  acccgccac  acgcccagc  aattttttc  tatttttag  agagacggg  5460
tttcactgt  ttagccagg  tggtctgga  ctcctgacc  tgtgatctg  ccgcctcag  5520
ctcccaaag  gctgggatt  caggtgtga  ccaccgtgc  tggctgagc  ttaatctct  5580
gaacccact  ccagtctgg  ggatataag  tcccattct  tagttgtgt  caaatcaat  5640
aaaagttct  ataaattag  cccattttt  tacatgctt  catcctatt  ataagttgg  5700
aaaaagcaa  actacagcc  cttggtatg  tctaaagca  gttatgaga  caggcatgg  5760
ggctatgtc  gtaatccca  cactttggg  ggccgaggt  ggcagatgg  ttgagctca  5820
gagttcgag  ccagcctgg  caacacagt  agaccctgt  tctactaaa  atgcaaaaa  5880
ttagccagg  atggtgaca  aagcctatg  tcccagtta  ttgggaggc  gaggtggga  5940
gatcacttg  gcccggaag  tggaggctg  agtgagcca  gattacacc  ctgcactcc  6000
gcctgggtg  cagagcaag  tcctgtctc  aaaataaat  aataggccg  gcgcagtgg  6060
tcaagcctg  aatccgaga  ctttgggag  ccgaggcag  tggatcacc  gaggtcagg  6120
gttcgagac  agcctgacc  acatagtga  accccgtct  tactaaaat  caaaaatta  6180
ccaggcgtg  tggcgggca  ctgtaatct  ggctacttg  gaggctgag  caggagaat  6240
gcttgaacc  aggaggcag  gggtgcaat  agcagagat  gcaccattg  attccagcc  6300
ggacaagga  agtgaaact  catctcaaa  aaaaaaaaa  aaattcaat  aaaaaaaaa  6360
aataaataa  taaagcaag  taggccagg  atggtggct  atgcctgta  tcccagcac  6420
ttgggaggc  gaggcaggc  gatcacaaa  tcaggagat  gagataacc  gggtaacac  6480
gtgaaaccc  gtctctact  aaaatacaa  aattagccg  gcatggggg  acgcgcctg  6540
agtcccagt  actcaggag  ctgaggcaa  agaatcgct  gaacttggt  ggcggaggt  6600
ccagtgagc  gagatagca  cattgcgct  cagcctggg  gacagagca  gactttgtc  6660
caaaaaata  ataaataaa  ataataaag  aagttatga  actcttgga  tgttcaaaa  6720
cagaatgtt  caatggtat  tcccttgct  tagaaagtt  tatctactg  ctagaagga  6780
tctgcctcc  ggcacagtt  acttggtat  ttccaatca  tacgagatc  aactacttg  6840
tataaccca  agcaagttt  aaaactttt  ttatgcttc  aggccaggt  tggtggctc  6900
cacctgtaa  tccagcact  tgggaggcc  aggcaggtg  atcacttga  gtcaggagt  6960
caagaccag  ctggctcac  gggtgaaac  cggtctcta  taaaaatac  aaaattagc  7020
aagcgtagt  gcgtacacc  gtaatccca  ctacgtgag  ggctgaggc  cgaaaatcg  7080
ttgaaccca  aggctgcag  gagccaaga  cgcaccgct  cactccagc  agggtgaca  7140
agtgagact  tgtcttaaa  gaaaaaaaa  gtaaaaata  aataaaaca  aatgctcca  7200
tcattacat  gtctggtgt  tatgtcccg  tgacctgaa  cccttggta  attcaagtt  7260
ctataagat  ctcatctcg  ccgggtgtg  tggctcacg  ctgtaatcc  agtactttg  7320
gaggccgag  caggcagat  acgaagtca  gagttcaag  cccgcctga  caacgtgat  7380
aaaccccgt  tctactaaa  atagaaaaa  tagcttggt  tggtggcac  tgcctataa  7440
cccagctac  caggaggct  aggtaggag  atcgcttgg  cctgggagg  agaggttgc  7500
gtgagctga  accgcgcca  tgcactcta  cctgggtga  agagcgaga  tccgtctcg  7560
aaaaaaaaa  aaaaaaaga  tatcatctc  tggtacttc  cacagcaaa  cccaagcac  7620
ttgatatgc  ctactgtct  agtgaactc  ccacctgta  ctctcacag  ctacatggt  7680
cacctctca  cacagtcca  caaggtcca  aggcattgt  gacataccc  gttctcgtc  7740
taaggcctc  ctctctatc  tagcacaat  aaggcaagg  tctcctata  acacagcca  7800
actgagtat  gtcttggtg  tacagaaat  ccctaattt  cagaccaac  tcccatctc  7860
gggcctcac  gtgctgggg  gctgcagtc  tgtggtgcc  ccgggcaga  agctgagca  7920
ttcatcatt  taactggac  ccaggctga  gatctcatc  atgacatca  caatctagg  7980
gaagaagta  atattatac  ggtttagaa  aatttggga  gggaatgtg  gaggaggtt  8040
ggctgtagc  tcttacctc  ttctctgag  tggacccga  ggtgagcag  gccatgggg  8100
tgttgggcg  actgcctgt  gggccggta  tgtgggcag  ctcaggggc  ggcagtggc  8160
gggcacttg  gggccccgg  ggtggggtg  gggcctggg  agccagctt  ggcccgagt  8220
tggtggaca  gtactgttt  acctgctgc  ggcgcgcct  ctgcaggtg  tagcgcgtt  8280
ggttctcca  atgggtctg  acctgtgaa  taaggtaga  aaggaaaga  aggggacaa  8340
gcagaacag  actcaaagg  gtgaattct  agccccagc  tgaccctcc  aactcattg  8400
tgcctagac  cacgcagac  agctgggcc  agaatctga  aacacccca  aaatattag  8460
gagtctccc  caggaccca  actctcttt  tcagaaatc  ttcacagct  ccaagatcc  8520
cccatgact  acaggatcc  tcgtagttt  tggaaaacc  tgtcacagt  cccaagatt  8580
cccacctag  ctctgacac  acctaatag  cctgggaac  atacaatgc  tcccaagac  8640
ccctaatgg  caaagaact  atgtatccc  cacacatga  gctcttcct  caaagccag  8700
gcccacttg  ggcactcat  agcctccat  gtccaccaa  acatcctca  ggcccccac  8760
aactcctcg  aatttcaca  gatcatctc  gaaacccaa  acacatgag  catgaacac  8820
gataattta  acagtacca  ggaccttcc  tagagcccc  aagaccttg  ccccaaatc  8880
ccagtgcat  gaggccatc  ctagctcct  ggatcactc  tcagtcacc  ggagccccc  8940
cccagggcc  ctggatctc  ccttacctt  agcacctcc  tgggcacct  agcaggggg  9000
ggacggctc  atgtgtggc  cccagcaga  acgccaacc  cagagatgg  aggagaggc  9060
ggtgcagga  tggggaagg  agccgcggc  gcctgttcc  gacgctcac  cctctcctg  9120
tcctgcgcc  gggcccgca  tagctgctg  cgcagcaag  ccctcgatg  agaagatga  9180
gacatggca  gggtcctgg  gccccctgc  gaagacgat  cagagagtg  agctggggt  9240
gctggtgtg  cctgcagtg  tattgggag  ctgtggaat  ggaaatatg  ggccatatt  9300
taggtaagc  aaaagtctc  tcccaagcc  aaagggtct  agcgtgacg  agcagacac  9360
ggaaccagg  ctgttctct  ccttccgag  ccacaatgt  gaagcagag  cacaggaac  9420
aggcttggt  atggctctc  ggggtcaca  tctgatggg  gacacactg  aggtcagtc  9480
ggtggggga  ttttagcct  tggtcctta  ggtgaagcc  agatttgag  ctgttcaca  9540
attaagtgg  gatgctatt  ttcagctct  caagggggg  tttgtccta  ttacaggag  9600
gcagaagaa  cagaattga  gctttggca  cagaatgtg  atacagagg  ctcctaagc  9660
caatgtgag  ctagagaag  tctctgagc  cctgggggt  ggcgtcagg  gataggaga  9720
gccccaggt  cctcttctt  ccctgcctg  gcctctggt  ccaggagct  gtcagtctt  9780
aaaacctcg  agatttcac  atactctct  cctgcccct  ttccccctc  cctcccctc  9840
ctcagagcc  gggccgatg  ctcagcaca  ttagacttc  aagcttggg  aaagaagag  9900
ccagcaggg  ctcctcaag  gctgagggt  ggtgagttg  tagtgtggg  agggactga  9960
ttggggcta  aggcatgtc  ccgcccacc  ggggacatg  gtttaagca  gccacgccc  10020
atctctgag  actccaggc  ggctggaac  cctgaggct  aaacacttg  atatgaatg  10080
gtgtgcagg  gggctgggg  caggcaggg  aggtcttga  agagatact  gaatcctag  10140
ttggccacc  actttcctg  gtgacatgc  ctttctggt  cctaatttt  ccaccacta  10200
aaaacgcag  ctggtgaaa  aatgggttg  gctggtact  agggcctct  cccatcaag  10260
ggggagagg  gggctgagg  attgggagg  gaatcagat  gacaagtca  acatacctt  10320
agcgaaggg  taagggttg  cttttgagc  cgtagaagc  gtcaggatc  aggacgttt  10380
ctaattcta  gtcagcaac  atcccggat  ccggaagca  agagttcag  ctgaggggg  10440
ggtggagtg  tggtcagtg  ttgaatgaa  gaccttatt  cccagccct  ccctgagac  10500
gagaaagag  cagagagcg  gggagaacg  agaggaggg  acaagcccc  catatttgg  10560
caccttgct  ggtaccaca  caccatgaa  tcccacctc  ttcccccat  cccctttcc  10620
ttccccact  tgttactca  agtccctta  gagtcagaa  aataagaac  cctgcatcc  10680
aacccccac  ctgtaacaa  ctgggtttg  ggaaaacag  atttaggaa  aacaattca  10740
tttatagaa  gattcctga  ttcctattc  gagttctcc  agcccccat  ccccctact  10800
ttttttttt  tttgagaca  agtatcgct  tgtcaccag  ctggagtac  gtggtgcga  10860
ctcagctca  tgcaagctc  gcctcctgg  ttcaagtga  tctcacgcc  cagcctccc  10920
agtagctgg  attacaggc  cacgccacc  cgtccggct  atttttgta  ttttagtag  10980
gacggggtt  caccatatt  gccaggatg  tctcgatct  ctgacctca  gatccgctt  11040
cctcggcct  ccaaagtgc  gggattaca  gtgtgagcc  ctgcgcccg  ccaaccccc  11100
gctattttc  ttacagctg  atgtgagcc  aggtatatg  gtgtacaca  acacacaca  11160
agagcaagt  ggggcatcc  tcagcataa  agtcccttg  aacacaaac  gaatgcatc  11220
caaagagaa  tggaaataa  tcacttgac  taaagatct  ccatttcac  aatgagttt  11280
tcccagccc  agccagagt  catgggatg  caacacatg  ctaaatata  aatagaaat  11340
tcaaaggct  ccctcgctc  aacagactg  atttacaag  gggagaatt  gggtggttg  11400
tccacttta  acaagcatt  ttttcttac  ggaggagcc  gcccagcct  ctcctgttt  11460
tttggatag  tcaaaacac  cacacaccc  caacactaa  acccactgg  gcacaaaat  11520
agaagccat  tacacccat  cctttaact  tgtccacta  tgcgatgat  taggttgtt  11580
cagaggaat  agaagatgg  gaatcgata  acagaaagg  tctgctcag  cccagagag  11640
aagggacag  taacacaca  gtggatgaa  atgcatcct  caatttagc  aaacattta  11700
aatgctgag  gattgctgg  gacttcact  gacaagaat  ctctcccct  cccaaggat  11760
tgtcttcct  cctctcctc  ccctcagat  gagccctaa  accacccag  aagttggga  11820
gaggaagct  gggcaagcc  ctgagctca  cacaatccc  ggcacaaag  aggcaaaga  11880
cccccccac  cagggctca  acacccatt  cacagaagt  ggaagagat  ggcactggg  11940
tgagcaggg  gggctgggg  tccaaagcc  attgatgaa  gtaaggatg  gaagaggcc  12000
gaggggatc  acccaggca  ggatggtgc  atctgtact  gttccagct  tatggacag  12060
ttcaagatt  cccccagga  ctcggagat  gaaaagaag  taaaaagaa  aggggtgtg  12120
ggctaggga  tgggaaggg  tgagaggct  gagcgagta  cagcatgaa  aagagcctc  12180
tctgggttc  caaacaagg  ctgaggcct  tgagctaag  ggtaacatc  tcgccctct  12240
cctggctgt  tatcttcca  tcaggccct  aacaggtgt  ggaagaggg  ttttccact  12300
tccttggga  ctgccccag  tgggtaggc  ggcagaggg  aaaggatta  tctggtcaa  12360
tcttgctga  tgttgcttc  cttgttcat  cacacgcac  cacaaggct  gtcccaggc  12420
gcatatctg  gatacctcc  aatccctcc  gattcatgt  atccccaaa  acagcaacc  12480
gtcactgag  ggcaccaag  tcccaagac  gcacttctg  ccctcagga  cccttctcc  12540
acactgagg  aaaaaagat  ctaggattc  cttaaaacc  gtgcctcac  tgacagtgt  12600
ccctcaaat  cattcccct  atgtccgac  gaaaatccc  gaattcagc  tctaatcag  12660
gaccctgtc  accaagttc  gctatctca  accagtttc  ggatactcc  gaataggcc  12720
cgctagacg  agtcaaggg  tccccaaac  tgacccaga  cccgcttaa  gcactccca  12780
gactccttt  ataaagcca  aatccaagc  ggccactgc  ggattcctt  ggtgccccc  12840
caagacggg  gccccgacg  cctccaagg  taggccgag  gcctccaat  ccagtccgg  12900
gcccccgct  cccccgaga  caggcccct  ggagcccca  tcggcactc  cagccccag  12960
cggccccgc  cctgagcag  tgagccgag  cggccggcc  gcgctcctc  aacagcacg  13020
acacggctc  agggccctc  gcgctggcc  ctacgccat  ccgagctgg  tcggccgca  13080
gagacatga  gcccggccc  gggcgagcc  tgccaggcc  gtcgggcct  ggcccggtc  13140
ccctaacaa  ataagagtc  cccctcccc  cagctcgcc  ctgccgcct  ctccgctaa  13200
ccatggagc  agcactgcg  gggcgggcg  cgtctggga  atgggatgg  ctgtgagtc  13260
tcccccgcc  agaacggac  gacgccccc  ctcaaccta  ccccggacg  ccgccctcc  13320
ccccctcgt  ttcttcccc  tcctccctc  tcccaggga  ggggaaact  cacaggaag  13380
gaccgcact  gggatggat  gcccgtctg  ccacgaccc  ttagcgagg  ggccaatcg  13440
tgaacggcg  ttcgagggc  caccctaag  gacgcctcc  acgcggagg  aaaacgcga  13500
tcggcccgc  ctcattccg  gaagcagca  ccagaccac  ccctcaggg  cagcgacaa  13560
taggcgagg  ttgatttgg  tgaaccacg  ctctatgtt  gcgtcgctt  cggagccac  13620
ccctctctt  tcaaattat  cctctgcaa  gtaatatta  gccgctcct  gggtcctct  13680
cgcctgcgc  tcgatggcc  gtcggcgca  ggagggtct  ctggccaag  ttttagctg  13740
ggaaccgcg  cctctttcg  ccaatattt  taatatctg  gccctagac  gcgctccaa  13800
ctcgatctg  ctgtgctct  tcagccaaa  ccataacta  gaggcacag  cagctacat  13860
ccctgaagg  gcgggccag  aaccccccc  tttcgctgt  cgcagtcca  ccgcccagc  13920
ggtcttccg  gagtattcc  cctgttcca  gccatcgag  gcggttgta  tatgttcat  13980
gcgctgcgc  atatgtgct  aataaattc  tgacgggtg  atgaatctg  tcccttcgg  14040
gaatgacga  ttctggaat  acaaagatc  aggtttgaa  agggaaggg  acctcccct  14100
tcccagcct  agctttcct  gcctgttaa  tgggggtca  aatacctgt  tggcagggt  14160
gttctgagg  ttaaagata  tgtatgaaa  gtgctagca  gttgtttgg  atacaagaa  14220
cttcccaaa  ttagttgat  cactcattt  ttcacttat  caacattca  tgagcgctt  14280
tgtatgcca  acgcatgca  gccggctcg  acaaggcgg  gggtctcac  catatatcc  14340
caggtgcaa  tagctcaca  aacacccag  cctacagcc  tcccttcct  tttcctgac  14400
tcccaagac  ccaccctga  ttgcgcctc  aggaatttc  ccgggcttt  atttacctt  14460
gaccttcct  tattggcat  attatttca  aggtctgtc  gttgctttc  taaactcat  14520
catactcac  cacaaccat  tcgtacaag  gggaaacct  tacataata  agatgactt  14580
tggccgggc  cggtggctc  tgcctgtaa  cccagcact  tgggaggcc  aggcgggtg  14640
atcacctga  gtcaggagt  tgagaccag  ctggccaac  cggtgaaac  ccgtctcta  14700
taaaaatac  aaaaattag  cgggcgtgg  ggcgggcgc  tgtaatccc  actactcgg  14760
aggctgagg  aggagaatc  cttgaacca  gaagcagag  ttgcagtga  ccaagatag  14820
gtcactgca  tgcagcctg  gtgacagag  gagactcag  ctcaaaaaa  aaaaaaaaa  14880
aaaaaagaa  acattacca  ttgtaccaa  caaaactct  aaacggaac  tgtagatcc  14940
atgttaaaa  tcctatgat  ccttaaaca  gtaagaatg  gccgggcac  gtggctcac  15000
cctgtaatc  agcagtttg  gaggccaag  ttggtgggt  gcttgaggc  agaagttcg  15060
taccagcct  gccaacatg  caaaacctc  tctctacaa  aatacaaaa  ttagccggg  15120
gtggtggtc  gcgcctggc  tgtagtccc  gctactcgg  aggctgagg  aggagaata  15180
cttgaaccc  acaggcgga  gttgcagtg  gccgagatc  cgccactgc  ctccagcct  15240
gggcgacag  gtgagactc  gtctcaaaa  caaaaacaa  ggcccagtg  ggtggctca  15300
gcctgtaat  ccagcactt  gagaggccg  ggcaggtgg  tcacttgag  tcagaagtt  15360
aagaccagc  tggccaacg  ggcaaaacc  tgtctctac  aaaaataca  aaaaattag  15420
caggcatgg  ggcgtgcgc  tgtaatccc  gctactagg  aggctgagg  acaagaatc  15480
cttgaaccc  ggaggtgga  gttgcagtg  gccaagatc  tgccactgc  ctccagctt  15540
ggagacaga  ctagactcc  tctcaaaaa  aacaaaaac  aacatgtaa  aatggctaa  15600
tttacaaaa  aagaaagag  agggtctgg  ggggtggtt  ccacctgta  tcccaacac  15660
ttgggaggc  aaggtggga  aattgcttg  gcccgggag  ttgagacta  tctgggaaa  15720
atagggaga  cccgtctgt  caaaaaaac  tttaaaaaa  taggccggg  atggtggct  15780
acgcctgta  tcccagcac  ttgggaggc  gaggcggga  gatcacaag  tcaagggat  15840
gaggccatc  tggccaaca  ggtgaaacc  cgtctctac  aaaaataca  aaattagct  15900
ggcatggtg  cacgcgcct  gcctgtagt  ccagctact  gggaggctg  ggcaggaga  15960
tctcttgaa  ccaggaggc  gaggttgca  tgagccgag  ttgcaccac  gcactccag  16020
ctggggaca  agtgagact  tgtctcaga  aaaaagaaa  aaaaagaaa  gaaaagaaa  16080
gaaaaatta  ccaggtatg  tggtgcaca  ctgtggtcc  aactacttg  gaggctgag  16140
caggaggat  gcttgagcc  ggaaagttt  aagttgcag  gagccgtgt  tgtaccact  16200
ccctccagc  tggacgaca  aatgagact  tgtatcaat  aatcaataa  taaaactac  16260
tactgtctg  tgaaagatg  tacaaagtt  aaagactta  aacagactg  caacaaata  16320
ttatagcag  agagccaca  agtaattat  ttgtcacac  tcccaatcc  acaaacacc  16380
gcttcacac  cgcatctca  atgtctcca  gacaagtga  atcccatga  accctgcat  16440
atatgccta  cctgcatct  tctgggttt  tctctctct  ttctttttc  ttttttttt  16500
agacagagt  tcgctcttg  ccaggctgg  gtgcagtgg  acgatctcg  ctcactgca  16560
gctccgcct  ccgggttca  gccattctc  tgcctcagc  tccccagta  ctgggacta  16620
aggcacccg  tactatgcc  ggctaattt  tttgtatgt  tagtagaga  ggggtttca  16680
catgttagc  aggatggtc  tgatctcct  acctcgtga  ccgcctgcc  cggcctccc  16740
aagtgctgg  attacaggc  tgagccact  cacccggac  tcttttttc  ttttctctc  16800
ctctttttt  ttttttttt  tgagatgga  tctcgctct  tcacccagg  tgaggtgca  16860
tggcactat  tcggctcac  gcagcctct  cctcctggg  tcaggcgat  ctcctgcct  16920
agcctccca  gtaactggg  ttacaggtg  ccgccaccg  ggccagcta  ttttttttg  16980
atttttagt  gagacaggg  ttccccatg  tggccaggc  ggtttcaaa  tcctgacct  17040
aagtgatcc  cccgcctca  cctcccata  cgctgggat  aaaggcatg  gccacatgc  17100
cggccctag  ttctatcaa  atctcattc  caactttct  aatacttgc  cccctgcca  17160
atagttgga  ttcctttct  tctttcttt  ttttttttt  ggagacagg  tttcgctct  17220
tcatccagg  tggagtgca  tggtgcgat  tcggctcac  gcaacctta  ctggggttt  17280
actgcaaga  aacttcaag  tgctgtgaa  gggacatgt  gagcgaagt  ggagggcag  17340
tggatggtg  agttggggg  atttaggga  agatatgag  ggtgattga  ggtggcttg  17400
gggtgagtt  gggttctac  acaggacag  ttgcaggca  ttgaaggat  atttgaagg  17460
ctttgggag  aatggggct  caataagac  gtttaagaa  gcaggtggg  gctattggg  17520
gggtggatt  ggaatacgg  taatgggtg  aggatggtt  ggggtacag  tggagggaa  17580
ataggaaga  gggttttta  agatagagt  cggccttct  taaggtggt  taaggaaca  17640
atgttaact  tcataagat  ttgtggtag  ctgaataat  ccctccacc  ctgccaata  17700
atttatgtc  tatgtccta  tccctggaa  tttttttta  ttaattaat  ttttttaga  17760
aaagtctca  tctgtcacc  aggctggag  gcagtggtg  gatcttggc  cactgcaac  17820
tccggctcc  gggttcaag  cattctcct  cctcagact  tcgagtagc  gggactaca  17880
gcaggcacc  gccaccacg  ccggctaat  ttttgtatt  ttaggagag  cggggtttc  17940
ccgtgttag  caggatggt  ttgatctcc  gacctcgtg  tctgcccgc  tcggcctcc  18000
aaagtgctg  tattacagg  gtgagccac  gcatccggc  aaggaactc  tttttttta  18060
agagtcttg  tctgtcacc  aggctggag  gcagtggtg  gatctcagc  cactgcaac  18120
tcgtcttcc  ggttcaagc  aatctcttg  ctcagcctc  caagtagct  ggattacag  18180
catgctgca  catgcccca  taatttttg  atttttagt  gtgacagag  ttcaccatg  18240
tggccaggc  agccttgaa  tcctgacct  aagcaatct  cctgcctcc  cctcccaaa  18300
tgctgggat  acaggcatg  ggcatggcg  ctgccccct  acccatttt  tttgtttgt  18360
ttttgagtc  aggtctcac  ctgtcaccc  ggctggagt  cagtggcat  atcacggct  18420
actgcagcc  ccatctcct  gactcaagc  gccctcccg  ctcagcctc  cgagtagct  18480
ggactacag  tgtgtgaca  catgcctgg  taattccct  gaacctttg  atgctactt  18540
atgtgacaa  aggactttg  aggtgtgat  aagttaagg  ttttgggat  aggagattg  18600
tctggatta  ctggtagac  ctaactgta  tcctaaatg  tcttataag  ggtaggcag  18660
agcaaattc  actgacaga  aaggaggag  caatttgac  acggaggca  actgtagtg  18720
tatgactgc  aaaagccaa  gaatgcctg  agaggcaac  gatagtcct  tttgtttgt  18780
tgtttgttt  tttgtttca  atggaatct  gctctgtca  ccaggctgg  gtgcaatgg  18840
gcagtcttg  ctcactgca  cctctgcct  ctgggttca  gcggttctc  tgcctcagc  18900
tcccaagta  ctgggacta  aggcgcccg  caccatgcc  gattaattt  tgtattttt  18960
gtagagacg  ggtttcgcc  tgttggcca  gctggtctg  aattcctga  ttcaggtga  19020
ccacctgcc  cggccttcc  aattgctgg  attacatgt  tgagccacc  cacctggcc  19080
aaagacaat  tttccatgg  gtgtggtgg  ggatggttt  ggaatgaaa  tgttccacc  19140
cagatgatc  ggcattagt  agattttca  aaggagaat  ttgtaagca  gtaacctgg  19200
tcccttgca  gcacagttc  caatagggt  tgctctcct  tgagaatct  atgccgctg  19260
tgctgtgac  gaagctgga  ttcaggtgt  aatgcttgc  tgcctgcca  tcaggctcc  19320
aacaggcca  tgactggta  ttgtccttg  cccaggggt  ggagatccc  gccttatag  19380
ctccagagg  agtgcagct  tggtgacac  ttaattttg  cccagtgca  ctgatttta  19440
acttctggc  cttaaaact  tgaaagaat  catttctgt  ttttgtttg  ttttaagag  19500
ggtagctat  tatttattt  tttatttag  gatggagtc  cgctctatt  ccctggctg  19560
agtgcagtg  catgatctt  gctcactgc  acctccacc  cccaggttc  agcgatgct  19620
ccacctcgg  ctccctagt  gctgggact  caccatgcc  ggctaattt  tgttaaatt  19680
ttttagtag  gacgggatc  ggccatgtt  tccaggctg  tctcaaact  ctggcctca  19740
gtgatctgc  agcctgggc  tcccaaagt  gtggtatta  aagggtgag  cacgcaaat  19800
tctgttttt  tttcttctt  ttttctttt  tttttttct  tttttgttt  ttttgagac  19860
gagtcttgc  ctgtcgcca  gctggagtg  agtggcgag  tctcggctc  ctgcaacct  19920
cgcctccca  gttcaagcg  ttctcctgc  tcagcccca  gaatagctg  gattacagg  19980
atgtgccac  atgcccggc  aattttgta  ttttagtaa  gacggggtt  caccatgtt  20040
gccaggatg  tctccatct  ttgatctct  aatctgccc  ccttggcct  ccaaagtgt  20100
gggattaca  gtgtgggcc  tcctgcccg  ccctctttg  ttttttaag  caccaagtt  20160
gcagtaatt  gttacaaca  ccacaggga  gaactacag  tggctttgg  gaagagttg  20220
gggtcactg  aaggactta  ggctacgtt  ggggttacc  agggcagtt  gagagtata  20280
ttagaggct  tgggaaagc  tttgggtgc  gttggagcc  tcaaaggga  aattgaggt  20340
ggatttggg  ggtcattgg  gggtggatg  gaggtatag  tgggagact  tggggaggt  20400
aaggggaaa  gtttacagg  agcattggg  gctattaga  ggcagttta  ggtgtagtt  20460
ggagttctt  gagggtggt  tgggtggta  tgttgggaa  aattgaaag  tgttttgtg  20520
gtgtagttg  tcataattt  agacaaggt  ggggctggg  gcagtggct  acacctgta  20580
tcctagcac  tggggaggc  gaggcgggc  gatcacctg  ggtcgggag  tcgagacca  20640
cctgaccaa  atggagaaa  cccgtcttt  ctaaaaata  aaaattagc  gggcgtggt  20700
acacatgcc  gtaatccca  ctactcgtg  ggctgaggc  ggagaatcg  ttgaaccca  20760
gaggcgaag  ttgcagtga  cagagatct  accattgca  tccagcctg  gcaacaaca  20820
ccaaactgc  tctccaaaa  aaaaaaaaa  aaaaaaaaa  agacaaggt  gggcatggc  20880
gtcagtgaa  agtggtttg  ggttacagt  tgggtctgc  gttctggga  caaaggaag  20940
tagttagtg  gtagagtca  ggctggggc  gttggaagg  gaattttag  ggtggggtt  21000
ggaattgtt  gagagtagt  tagttaggt  tgggtatta  tgaaaaggc  ttttgggga  21060
attcttggg  gttgataaa  ggcagtttg  ggatgtaga  cagactgct  gaaggtggt  21120
taggggtga  gatgaggct  gggagggaa  tttagtgat  atatttggg  attatagag  21180
ggtctgggg  acagttgag  gctggtagg  atggtccag  gtgcagttt  ggggtctgt  21240
ttgaagtct  gatgtcaga  gggtgtttt  agttgtggt  gaggagcta  tggtgggta  21300
tttggagag  agttaaaga  cattggata  actactgtt  agcaataaa  ggaacaaac  21360
actgttaca  gctaccaca  ggatgaacc  caaaaacat  aagctaaat  aaagatgtg  21420
gacacaaaa  atccacata  tgcattttt  tgaaatgtc  aagaaaggc  aatttatag  21480
gacagaaag  agatttgtg  ttgcctatg  ttgggaatg  gaatggcat  cagtcatga  21540
ggatttttt  ggggtaatg  aaatgctct  aaactgggc  atagcgatt  ttgcacact  21600
tggtaaata  ttttttctt  tttttttct  ttctttttt  ttttttttg  gacagagtc  21660
tgctctgtc  cccaggctg  agtgcagtg  catgatctc  gctcactgc  acctccgcc  21720
tccaggttc  agctattct  ctgcctcag  cccctgagt  gctgggatt  caggtgcct  21780
ccaccacgc  tggctaatt  ttgtatttt  agtagagat  gggtttcac  atgttggcc  21840
ggctggtcc  gaactcctg  cctcaggtg  tctgcccac  ttggcctct  aaagtgcta  21900
gattacaag  gtgagccac  gtgcctcac  taggtaaat  tactaaagt  gttgcattg  21960
acacttaat  gtggatgac  tttatggta  ataattatc  ttattattt  ttgagatgg  22020
gtctcactc  gttgcccag  ttagagtgc  gtggcacta  cttggctca  tgcaacctc  22080
acctcctgg  tttaagcga  tctcctgcc  cagcctcct  agtagctgg  attacaggt  22140
tgagccatc  tgcccagct  cttttttgt  tttttagta  agacggggt  tcaccatgt  22200
ggccaggct  gtcttgaac  cttggcctc  agtgatcca  tcgccttgg  ctcccaaag  22260
gccgggatt  caagtgtga  ccactgttc  cggcctggt  cgtaaatta  atcccggtt  22320
agttgtttt  agaaaaaaa  cactgagag  gctttgtaa  ttaggtcac  taagtatga  22380
ccagggtgc  agtaagtct  tggagggct  aggggacac  tttggggcc  ctggagtat  22440
atttgggag  ccaattggg  aactacagc  ggatggttg  tggctattc  gaggtacag  22500
tgaggactg  tggagagtg  ttgaggtgc  gtttgggtc  gtggagtgt  ggttagagg  22560
gtagatggt  ctggagggt  gcttgaaat  cagttgaaa  accacagaa  gtatagttg  22620
gttatatgg  acagtgata  gggctgttg  aaggtaatt  tgtggggat  cgaggggag  22680
tcaatgaaa  gtggctggg  aagaggggt  catggaaca  ggtttggag  tagtgtggg  22740
gactgttgg  attattttg  ggtgcaggt  aggcccacg  tgagggtaa  taggaatgt  22800
tgggctggt  ttgggggct  ctggagagc  attttgggt  aatggagta  ggtttggag  22860
gtacatgga  aggagtttg  ggtcaatgg  gggtgttac  ggtgcacat  ggaagtaga  22920
agcaggtga  ttggacatg  tgtttggag  gtaatggtt  cagggctga  tgcagatgg  22980
ttgatggag  aaactgggg  tagtgtaag  tagtttact  ccacagctt  ggtgtccat  23040
gagggtgga  tggaggtac  gcttggaat  aacagacag  agtttgggg  tataatttg  23100
aggataatg  aggttggtt  ggagtgcat  tgaggaaca  cagggaggg  agctggggt  23160
tacaggtgt  gggatagct  acagagagc  gcttggggt  ctgcttgag  gtccctggg  23220
gacgacttg  ggtgagggg  gccagtagg  tccctgagg  gcgtggcct  ggcgaggga  23280
ggctccgcc  ccctcgaga  agcgtgtgc  cacgcgctc  cagcttgtt  gctcctggc  23340
ctcccaggg  aagaaaaat  gaagacccg  gccggcgct  gcgcactta  tctccgcca  23400
tgctgtggt  tcgtgcccc  ccccccggt  cccccaccc  ctaggctag  ctgagcggc  23460
gaggtggcc  tgccgctgg  agcggacag  cccgagtta  aggtggggg  gggggtcca  23520
cgcccgcgg  cgggccggc  ctcccctcc  accctcccc  cgacccccg  ctggccccc  23580
cggctaacg  tagcgcagc  gaacacggc  cacgggcag  gcgccgaag  ggagcaggc  23640
cgcgcccgg  gacgagcag  gcgcagtga  ggaggggcg  gtccactgc  ccggccggc  23700
gaccgacac  gaccccgcc  actgcggcg  ggggaccct  ggtgagtaa  cagccccgc  23760
tgcggagga  gggagggga  agggtgggg  gaaggcccg  aaacgccga  ggggcgtac  23820
tgcgcgcgc  cccgcgacc  ctgaccccg  ggcctcagc  ctgacccct  acgacctga  23880
tacatcttt  ttaaacctc  acccctgct  gccttggcc  caggacctt  catccgagc  23940
ctgacctaa  catattctg  cctggtatg  tcctcaacc  ctgttttgt  cccctaaat  24000
cagtcctga  cccaaaccc  atccagtta  gtcctgggg  tctttgacc  gaccctgat  24060
cttgcctga  cccgtctca  ctctgaaac  tcttgccct  tcctaatgc  caacactga  24120
cccagtttc  gtcctgacg  ttgacctgt  tgttcccta  actcttatc  agtctccaa  24180
cctcttcca  tcatgtcct  tccccctaa  cacaatctg  tgtagttct  tcctgattc  24240
tgccctcta  cttctgtcc  ttctctgca  cctatgtga  atcctctcc  atatactcg  24300
gatctgcat  ctggctcac  accttcgtc  cctgccttg  ccctgcccc  gactctgcc  24360
cgtttttcc  tcttttctt  tcccatcac  atactcatt  ctatcctca  tgtgtcctg  24420
tcttttcct  ttcctgacc  ccatcctga  cctgccctt  tccctgtcc  ctcctttga  24480
cactggctt  gcctttcct  gtcatgtct  ctgactgct  ttctatgtt  atcctgacc  24540
ctgccctgc  gttttgtct  tttcttgta  tttttctct  acccttgtc  tgaacccca  24600
cttatccca  cccctggcc  gtgttctgg  tcattcccc  tcctgcctc  tgacctcca  24660
cctgtgata  ctctggctc  atcttgtcc  ctacactcc  tcctgttct  tcccttccc  24720
tcccagccc  agggtgttc  tccccttac  atgcccctc  accctgttc  gatcttctt  24780
cttcctaat  tccacttgc  atcccttct  agccgagga  aggggtccc  ttatactgt  24840
cccggaact  gaagattct  ctgttccca  gacctccga  gtacatccc  aatgcttct  24900
ttagcaaga  caagcagcc  tatgtgccc  gcgtggctg  tgggggttt  tgtgtgtga  24960
ctcccctat  cccacccta  tgatcttac  tagagctta  atttctctt  ctgccccag  25020
agggcatgc  actgttcct  cgcccctgc  ctctgcaag  gtgaaagaa  accctaaat  25080
attcagtga  tctctggga  tctgagagg  ctgggtcat  tttccagtc  tgctgtgtt  25140
gggactgcc  catgttggg  ggaagagtt  agaaaatat  aagagatgg  ggacccagg  25200
gtatgtatg  atcttctag  ccatgtttg  ttctgggtg  atgatccct  ctttcctgg  25260
ctgaaaaag  agaagtcta  tctaggcca  ggctttggg  cttggtata  aggagggat  25320
gggtcaagg  ttcattctc  ttctctcag  agtaagcaa  aaaaatctt  gtgctaagt  25380
cactccacc  ctgtggggc  tgtcttggg  gagaaggcc  ggcagtcac  ggatttaag  25440
atcaggcct  tccagtggt  acagtaaca  caataatgc  gtgttcccc  cattgtccg  25500
atctccttg  ttctgagga  gatggggag  acttggata  ctagagggt  atgtgttac  25560
caattgggt  ttgttcctg  atttctcat  gagactagt  agtttgaat  acaagatgc  25620
agacctatc  tatcctgaa  atctatcca  acctattga  aacaaaaca  gcattcctc  25680
ctttcccaa  ctatttggt  cctgaattc  gagagggag  gtgcccgaa  ttcagacag  25740
gaaacctac  aagttattt  aaggtattt  gttttcaca  cttacatag  gagtaggga  25800
aattgagat  atgaagaat  atgactaac  aaaaaatgt  tccaaatct  tgaactttc  25860
tgagctcca  ggacaagag  tgggatagt  agggtaccc  gttatgtaa  tggttcctg  25920
attttgttt  gagggtaag  aaagttcaa  aatgaggga  accagtcgt  tctcaaaaa  25980
gtttctgaa  ccattcagt  cttgcattt  gatggtgag  gttcagaca  tttctctga  26040
tgtatttgg  tcctgcatt  ttgatgttg  gaaaggaga  gttggatca  gagggaaac  26100
gctctgttt  aaatatgtc  catttggtg  gcagggagg  taccgtgtc  agatagcaa  26160
tgggatttg  aagctgagg  ataccagtt  tgtctcaaa  atgcatctg  ggccggtcg  26220
ggtggctca  gcctgtaat  ccagcactt  gggaggctg  ggcgggtgg  tcacgaggt  26280
aggagttcg  gcccaccct  gccaagatg  tgaaacccc  tctctacta  aaatacaaa  26340
attagctgg  tgtggtggc  cgcacctgt  atcccagct  ctcgggagg  tgaagcagg  26400
aactgcttg  acccgggtg  tggaggttg  agtgagccg  gatcatgcc  ctgcactcc  26460
gcctgggtg  cagggtgag  ctccgtctc  aaaaaaaaa  aaaaaaaaa  aaaaattgc  26520
tctgaatac  tttagtctc  gattttgga  agcaagagt  cagacaagt  atctgagga  26580
aaacaactg  ttcaaatgt  tcaagtgag  ctgaaggac  ccagctctg  ctggaaaaa  26640
tgtgtctga  tgtatctac  tgattcctg  cttcctgtg  ggaagaata  ttgtaactg  26700
gacagccaa  atacactga  ctcttacca  gcactgttc  gcacaagct  taaatgtat  26760
aactgattt  atgctcaca  tagccccgt  aggtacata  tgttatcat  gtccccaat  26820
gacagagag  cacagagag  ttaagtgac  tgttcaagc  gtcacacag  tagtaagtg  26880
cagagctgg  ttgaatccc  gactcacca  ttactagtg  cagcagggt  acgtgaggc  26940
cagggccca  ctggggtag  gcttagagg  tgggtcctc  tcgaggcta  taaaagtca  27000
ggaccaggg  aatgatgtg  gttagtgac  gccccattt  tctgcctgg  ccaggaggt  27060
cagttacct  ctctccccc  gttaccccc  caacagccc  cctctgtgt  agtgtatta  27120
ttgttgtta  taagagtca  taatgacat  gtgtgtttc  ttgcacttt  aaatgcctt  27180
caaagttat  tggggcctc  attgtctct  taaccacct  ttacccatt  tacagatga  27240
gagacctaa  ctttgagac  caatctaca  tgccagcca  attctcatc  ctcttggct  27300
tgattttat  actgtctca  ttcccaaca  ctttggtgg  ccataagag  tgggagagg  27360
tgtggccga  aggacactc  ccaatgccc  ccttaccac  gcccgcccc  ggcagtgaa  27420
tggggaggg  gatgaaagg  gcctttgtg  tccatgctg  aaatctcac  cccaggaag  27480
aaggtgggc  gggatggcg  gaggcctta  tagtatgag  ctggggcat  gctgattca  27540
agtgagctc  tctctaggc  cagcccatc  gcagctttt  tcacttcag  tcatggtgt  27600
ggctgctgc  ggggtctgg  tagggcttg  gccctgggt  acagagcag  tggtcctga  27660
tggagcaca  gatgtgtgc  gtgtgccgg  actggccca  agctcaggt  gtagtggtg  27720
tggtggtgg  ggtgatggt  gtggtggtg  gcggggtga  gggaggcag  gacagtacg  27780
cgtaaggac  caaagctct  atttccttc  ctggcatga  gcctgactc  ctgaagaag  27840
gagacccag  atggatgtg  agaagcatg  gcccccttc  ctacttctc  ttcccactt  27900
caggagtag  ctctgtctg  ctcccagcc  ggacccagc  cccggaaat  ctgatttca  27960
ctgctcttc  gccactgtg  tctgaatca  gcctcttca  ctttccagg  ctcagcttc  28020
gcatctata  aatggctgt  aggaggctg  gtctgtgcc  tcctgctac  tttgtagga  28080
ccaagaggg  tcaaaaccc  taagtgttt  gtagggtgt  agttgtgct  gatttattg  28140
gattatttc  tctggagcc  cagaaggat  ttgagacct  acctctcct  agaaaggtt  28200
acttcctct  tccccaact  gggaaacta  tattcccca  tgagggtgg  aattgcccc  28260
aggccttct  ccactgcct  gccctggga  gaaagggta  gggcctcag  atgtgatgc  28320
tagtgccaa  acacaaaaa  tcagtttac  cccgaagcc  cccatgtac  ttacagctc  28380
ccacacctc  atggcccag  tccaagttg  cccttgggt  ggcagcgtc  aatcctctg  28440
gaatttggg  agtaggaga  gcagctgct  ctcccacca  tctcagccc  tcttcccag  28500
tttctgcta  gtgtacggg  tgaggaggc  caggcctcc  tgcctggcc  gttttaaaa  28560
aaatttttg  agagatggg  gtctcatta  gttgcacag  ctggccttg  actcttggc  28620
tcaagcaat  ctcccacct  agcctccca  agtgctgag  ttacaggca  cagctaccc  28680
gcctggccc  ggctgtctt  ttagacatg  tgagcaccc  gagtggacc  ggccctgaa  28740
ctgccccca  gggtgaccc  agtcctggt  gcagacagg  aagggttaa  aggtgtggg  28800
cggcccagt  cctggccag  taggctggg  cattaccta  tgggaggtg  ccaaggcat  28860
tgccactgc  gctgactgc  actaccagc  ggagccagg  cctggtcga  acaactatt  28920
ttgaggtat  tgaggctac  ccacagcac  ctctggcat  ggtgagcac  tgggagcag  28980
gggcccagg  tgcgagggg  ataagggca  tggggagct  gggcagggt  tactgaagt  29040
cccttcggt  gagagctag  tctgtggga  aggcacacc  acaatgcag  gcagggtgg  29100
ggtgggggg  taggggggc  gtgagaatg  agggcctga  gacaggggc  aagcccaaa  29160
caccaattt  ctttcctgg  accaagccg  ttcccggcc  gaaatggac  aggagggat  29220
ggggaaaag  gaagtatga  tcccccctt  tccacccta  ccctgcttc  tttcctccc  29280
gccaggagt  gcctctgtc  tcccccaac  cagggccca  ctctccaag  aagaccaga  29340
tgggctact  agaaaccat  actcaggca  ctgcctgcc  atgcctgat  tgttcactg  29400
agtggagga  gcaggggct  tggggaggg  aatggccca  acattgaga  tttgtattt  29460
ctctaatag  ggcaggatg  ggaaatgac  ccccaagtg  tggggtgcc  cccaggtga  29520
gtatcttgg  tgtaaacag  tattacagc  aggaatttc  ttctcggct  tggtgtcag  29580
atggcagac  tgaaaaacc  gccgggccc  cctctgggt  tggggggtg  cctctactg  29640
tctcccgct  cagctggtc  ctgggacag  atgggggcc  tggggtcac  ggtaggggg  29700
gacctgggg  tggtgtggg  gtgtgctgg  gaggggttt  ctgggatcc  tttctcgcc  29760
tctgggcgg  gatgaggca  ctccaggcc  caaggcaag  atgcagagg  caggtgagc  29820
gaggcagaa  cttaggaac  gggtgtggg  gtgtggggc  ttgactgtg  ctagcctgc  29880
cagtgaccc  atgactcat  ctctaacta  gtccccccg  ggtcgggct  atagggagg  29940
gttggggtt  ctgtgtgga  cctgtctgg  cttccagga  gctctgaga  attagagaa  30000
aaaggattg  ctgggtgca  tgcctcacg  atgtaatcc  agcactttg  gaggccgag  30060
cgggtggat  acctgaggt  aggagttcg  gaccagcct  gccaacatg  tgaaaccca  30120
tttctacta  aaatacaaa  gtagccagg  atggtggcg  gcacctgta  tcccagcta  30180
tttggaggc  gaagtggga  aattgcttg  acctgggaa  tggaggctg  agtgagcca  30240
gatcgtgcc  ccactgcat  ccagcctaa  tgacagagc  aggccctat  tccaaaaaa  30300
aaaaaaaaa  aaaaaaaaa  agaatcgaa  cagcccagc  tggaattgg  attggattg  30360
gaccaatgc  ggcaagggg  accgtggat  gagttgggt  cctgtgggg  taaaggaag  30420
ttccaggga  ccctgtgag  gttccttgg  cctaaatgg  ggctgggaa  gttggagcc  30480
cagtgatct  ggatgtgga  gaacccctg  catgctggg  agtgtcaga  cttagatga  30540
tggggatgt  gggcctggg  ttgtcaaaa  gctttaggg  ctgatcccc  cccctgctg  30600
tgaaggcag  gcaccactg  ttcaagaga  gggtacagg  cctatgggg  aggcaggag  30660
actgcagag  aacatgaca  cttacaagc  gcttggcct  accccacaa  acacagatg  30720
ggaaggggc  tgaacccat  cctccttgg  tggctgggt  ttcctcaca  caggctaac  30780
tgtcatgac  agctgccga  ttcaaggta  gtgataatg  agctctgtg  ccccataaa  30840
ccctcccag  cacctgcca  ctaggttag  ccaggtggt  ggaggtgat  tcactcagc  30900
gcccagctg  ggactgagc  tgatgtgga  ggaagggag  aaactccag  ggaggggtg  30960
ccagccaag  caggttcca  ggtcagctg  gccatcggg  gcagagaag  aggcaggag  31020
caggtggtt  gttatttgc  gctgtggac  ttgcttctc  caaatccca  caggaggac  31080
tccctacac  aggctcagg  caggctgtc  tggcaagag  ggctggagg  accctgggt  31140
aagtgaaca  tctccttgc  acactagag  tacagaatg  agttgggac  agcacagac  31200
cacagatct  agcttgaac  ctggctcca  cgcctcctc  tttacttac  ctatctttt  31260
ttcattcag  tggcaccca  tcattgagc  cttgtgtgt  cagccatgt  cagggtgct  31320
gtgatgctg  tgaaaatgg  acagataat  tttcctgtc  tcgtcgatg  tccaggagg  31380
acaatctct  gttggacaa  cgtttgtga  aggatataa  tgtggaagt  ataattaag  31440
tctagaatg  taagtgtga  gcaggggct  gggtggtga  aggttgaag  aagcacttc  31500
ggcagcatc  acagcctgg  caaaggccc  gaggcctga  ggaccaggg  gcttatgag  31560
aagttggtg  agttagagc  gttctcatg  gcgagagtg  aggaccaga  gggtgggcc  31620
ggtttatgt  tgtggctat  ggccagtta  ttcacctct  tgccttcct  tcctcatct  31680
taaaatggg  atacgaatc  ttccgggtg  ctctgaaga  tgagtgtgg  atcatag  31737



<210> 9274
<211> 1871
<212> DNA
<213> Rattus norvegicus
<308> X06832
<400> 9274

caccaccat  accgccact  ccaccacca  cgctaccgc  gtgctccca  tggtgcaga  60
ctccagtgg  cacagaccc  cttccgcca  cctcctgca  cagctcgcc  tctctttcc  120
caccgtccg  ctcgctatg  gctcctccg  ggctttggc  cttctgctg  gcgccgggc  180
agtctttgc  cttcctgtg  acagcccta  gacaaaagg  gacactaag  tgatgaagt  240
tgtcctgga  gtcatctcc  actcgctgt  caaacccag  cccatgcct  tcagccctg  300
gtgtctgga  accctccaa  gagatgaga  ggtcctctc  atccttcga  accagaatt  360
gctgaagga  cttcaagac  tggcgcttc  aggtgccaa  gagcgggcc  agcagcagc  420
gcagcagca  cagcagcag  agcagcagc  gcagcagca  caacaacaa  acagcagct  480
tgaggatga  ctctcggaa  tatttgaga  ccagagccc  gcagccaag  atggagacg  540
agcatcaga  gccccctcc  aggacactg  agagaagag  gaggattct  acaaggggc  600
acaggatgc  tttgaggga  ccacagaag  acccagacc  caggccttt  cagagccca  660
gcaggagtc  tctatgatg  gaaacagtc  atctccagg  gaggacaca  ccaacaata  720
ccaatcacc  accagcctc  ccagccagg  gcatgggat  ccacagacc  cagaaggca  780
tgagagagg  cccagtgcc  agcagcaag  cagaaaagc  aagcaagag  agaaagagg  840
agaggagga  gagaaagag  aagaggagg  ggagaaaga  gagaaggcg  tcgccagag  900
gaaggctgg  cctaaagaa  tccccacgg  agcatccag  tctcacttc  attcaggct  960
caagaagat  cagaaagat  atgatggtc  gtcggagtc  caggcagtg  atggaaaga  1020
aggggcttc  gaagctgtg  catctgaag  gaaggggga  ctggagcac  ctcagcagg  1080
ggaagatgg  gaagaggcc  tggcagggc  cccccaagg  ctcttccca  gtgggaagg  1140
ccaggagct  gaacgtaag  agcaggagg  ggaagagga  gaggagcgt  tgtccagag  1200
atgggagga  aagcgatgg  gcaggatgg  ccagctggc  aaggagctg  cagcagaga  1260
gcggctgga  ggggaagat  accctgacc  gtccatgaa  ctctccttc  gggcccggg  1320
ctatggctt  agggaccct  ggcctcagc  acgccgggg  tggaggcca  cttccagag  1380
agacagtgt  gaggcccga  gcgactttg  ggaaaagaa  gaagaggag  gcagcgcca  1440
ccgcagagc  gaggaccag  agctagaga  cctgtcagc  atcgaggca  agctggaga  1500
ggtggccca  cagctgcag  ctttgcgac  gggatgagg  actggctgg  ggggtccgg  1560
catggcttc  aggcccaac  gctgctcaa  tagggaggc  tccagcctc  gagcccagg  1620
taccccttg  cccttccct  ctcttgctc  cagcccctg  cctggacac  tctgcaggg  1680
agccctgaa  gtcaacaca  attctttct  ggaacacag  cagctttct  gaagtttct  1740
ttccacctt  taatccatg  ggcacaact  cagtagttc  gatctttgg  cgaaagccg  1800
gaactcctg  ctattaaga  attccagat  aaatttatt  aaggaagaa  aaacctgct  1860
tcgggctct  c  1871



<210> 9275
<211> 466
<212> PRT
<213> Rattus norvegicus
<308> CAA29988
<400> 9275

Met Arg Ser Ser Ala Ala Leu Ala Leu Leu Leu Cys Ala Gly Gln Val 
  1               5                  10                  15
Phe Ala Leu Pro Val Asn Ser Pro Met Thr Lys Gly Asp Thr Lys Val 
             20                  25                  30
Met Lys Cys Val Leu Glu Val Ile Ser Asp Ser Leu Ser Lys Pro Ser 
         35                  40                  45
Pro Met Pro Val Ser Pro Glu Cys Leu Glu Thr Leu Gln Gly Asp Glu 
     50                  55                  60
Arg Val Leu Ser Ile Leu Arg His Gln Asn Leu Leu Lys Glu Leu Gln 
 65                  70                  75                  80
Asp Leu Ala Leu Gln Gly Ala Lys Glu Arg Ala Gln Gln Gln Gln Gln 
                 85                  90                  95
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His 
             100                105                110
Ser Ser Phe Glu Asp Glu Leu Ser Glu Val Phe Glu Asn Gln Ser Pro 
         115                120                125
Ala Ala Lys His Gly Asp Ala Ala Ser Glu Ala Pro Ser Lys Asp Thr 
     130                135                140
Val Glu Lys Arg Glu Asp Ser Asp Lys Gly Gln Gln Asp Ala Phe Glu 
 145                150                155                160
Gly Thr Thr Glu Gly Pro Arg Pro Gln Ala Phe Pro Glu Pro Lys Gln 
                 165                170                175
Glu Ser Ser Met Met Gly Asn Ser Gln Ser Pro Gly Glu Asp Thr Ala 
             180                185                190
Asn Asn Thr Gln Ser Pro Thr Ser Leu Pro Ser Gln Glu His Gly Ile 
         195                200                205
Pro Gln Thr Thr Glu Gly Ser Glu Arg Gly Pro Ser Ala Gln Gln Gln 
     210                215                220
Ala Arg Lys Ala Lys Gln Glu Glu Lys Glu Glu Glu Glu Glu Glu Lys 
 225                230                235                240
Glu Glu Glu Glu Glu Glu Lys Glu Glu Lys Ala Ile Ala Arg Glu Lys 
                 245                250                255
Ala Gly Pro Lys Glu Val Pro Thr Ala Ala Ser Ser Ser His Phe Tyr 
             260                265                270
Ser Gly Tyr Lys Lys Ile Gln Lys Asp Asp Asp Gly Gln Ser Glu Ser 
         275                280                285
Gln Ala Val Asn Gly Lys Thr Gly Ala Ser Glu Ala Val Pro Ser Glu 
     290                295                300
Gly Lys Gly Glu Leu Glu His Ser Gln Gln Glu Glu Asp Gly Glu Glu 
 305                310                315                320
Ala Met Ala Gly Pro Pro Gln Gly Leu Phe Pro Gly Gly Lys Gly Gln 
                 325                330                335
Glu Leu Glu Arg Lys Gln Gln Glu Glu Glu Glu Glu Glu Glu Arg Leu 
             340                345                350
Ser Arg Glu Trp Glu Asp Lys Arg Trp Ser Arg Met Asp Gln Leu Ala 
         355                360                365
Lys Glu Leu Thr Ala Glu Lys Arg Leu Glu Gly Glu Asp Asp Pro Asp 
     370                375                380
Arg Ser Met Lys Leu Ser Phe Arg Ala Arg Ala Tyr Gly Phe Arg Asp 
 385                390                395                400
Pro Gly Pro Gln Leu Arg Arg Gly Trp Arg Pro Ser Ser Arg Glu Asp 
                 405                410                415
Ser Val Glu Ala Arg Gly Asp Phe Glu Glu Lys Lys Glu Glu Glu Gly 
             420                425                430
Ser Ala Asn Arg Arg Ala Glu Asp Gln Glu Leu Glu Ser Leu Ser Ala 
         435                440                445
Ile Glu Ala Glu Leu Glu Lys Val Ala His Gln Leu Gln Ala Leu Arg 
     450                455                460
Arg Gly 
 465



<210> 9276
<211> 1994
<212> DNA
<213> Homo sapiens
<308> NM_001275
<400> 9276

gctgccacc  ctcctgcca  tgcagtgct  gagccccgt  caggggagc  tgcgggagg  60
tcgaccgac  gacggacgc  cgccgaggc  ctgcgcccc  agccccgcg  cggtgccac  120
gcagcccga  cccggccgc  agtccagcc  cccctcgcc  ggtgcctag  tgcccggcc  180
cacaccgcc  gctgctcgg  gcccgggtc  gccatgcgc  ccgccgctg  cctggctct  240
ctgctctgc  ccgggcaag  cactgcgct  cctgtgaac  gccctatga  taaagggga  300
accgaggtg  tgaaatgca  cgttgaggt  atctccgac  cactttcca  gcccagccc  360
atgcctgtc  gccaggaat  ttttgagac  ctccgagga  atgaacgga  cctttccat  420
ctgagacat  agaatttac  gaaggagct  caagacctc  ctctccaag  cgccaagga  480
agggcacat  agcagaaga  acacagcgg  tttgaagat  aactctcag  ggttcttga  540
aaccagagc  gccaggccg  gctgaaaga  gcggtggaa  agccatcat  caaggatgt  600
atggagaaa  gagaggatt  caaggaggc  gagaaaagt  gtgaagcca  agacggagc  660
aggccccag  ccctcccgg  gcccatgca  gagtccaag  ctgagggga  caatcaggc  720
cctggggag  aagaggagg  ggaggagga  gccaccaac  cccaccctc  agccagcct  780
cccagccag  aatacccag  cccacaggc  gagggggac  gtgagggcc  ctctcaggg  840
ctggtggac  gagagaagg  cctgagtgc  gagccaggg  ggcaggcaa  gagagaaga  900
gaggaggag  aggaggagg  ggctgaggc  ggagaggag  ctgtccccg  ggaagaagg  960
cccactgta  tgctgaacc  ccacccgag  cttggctac  aggagatcc  gaaaggcga  1020
agtcggtcg  aggctctgg  tgtggatgg  gctgggaag  ctggggctg  ggaggctca  1080
gaccccgaa  ggaagggag  acaggagca  tcccagcag  aagaggagg  ggaggagat  1140
gcagtggtc  cgcaaggcc  cttccgggg  gggaagagc  gagagctgg  gcaggagga  1200
gagcggctc  ccaaggagt  ggaggactc  aaacgctgg  gcaagatgg  ccagctggc  1260
aaggagctg  cggctgaga  gcggctgga  gggcaggag  aggaggagg  caaccggga  1320
agttccatg  agctctcct  ccgggcccg  gcctacggc  tcaggggcc  tgggccgca  1380
ctgcgacga  gctggaggc  atcctcccg  gaggacagc  ttgaggcgg  cctgcccct  1440
caggtccga  gctaccccg  ggagaagaa  gaggaggag  gcagcgcaa  ccgcagacc  1500
gaggaccag  agctggaga  cctgtcggc  attgaagca  agctggaga  agtggccca  1560
cagctgcag  cactacggc  gggctgaga  accggctgg  agggctggc  ccagggcac  1620
ctgtggccc  ggctctgct  tccccttgg  aggtcctgg  cagatggcc  ggacgctgc  1680
tccggtagg  aggcagcct  cagcctgcc  aagcccagg  caccctatc  ccccctacg  1740
gccttgtct  ctactcctg  ctcctacct  ccctggaac  tcctttgca  ggcagcccc  1800
caactttaa  cattgacga  tccttctct  aacacaggc  gctttctag  agtttccct  1860
cctccatcc  atccactgg  cacaactgc  ataacttct  accttttgg  gaaagctga  1920
aactcctga  tgtaacata  tctgtatga  ctttatcta  agaaaaata  atctgttct  1980
ggctctttc  tctg  1994



<210> 9277
<211> 457
<212> PRT
<213> Homo sapiens
<308> P10645
<400> 9277

Met Arg Ser Ala Ala Val Leu Ala Leu Leu Leu Cys Ala Gly Gln Val 
  1               5                  10                  15
Thr Ala Leu Pro Val Asn Ser Pro Met Asn Lys Gly Asp Thr Glu Val 
             20                  25                  30
Met Lys Cys Ile Val Glu Val Ile Ser Asp Thr Leu Ser Lys Pro Ser 
         35                  40                  45
Pro Met Pro Val Ser Gln Glu Cys Phe Glu Thr Leu Arg Gly Asp Glu 
     50                  55                  60
Arg Ile Leu Ser Ile Leu Arg His Gln Asn Leu Leu Lys Glu Leu Gln 
 65                  70                  75                  80
Asp Leu Ala Leu Gln Gly Ala Lys Glu Arg Ala His Gln Gln Lys Lys 
                 85                  90                  95
His Ser Gly Phe Glu Asp Glu Leu Ser Glu Val Leu Glu Asn Gln Ser 
             100                105                110
Ser Gln Ala Glu Leu Lys Glu Ala Val Glu Glu Pro Ser Ser Lys Asp 
         115                120                125
Val Met Glu Lys Arg Glu Asp Ser Lys Glu Ala Glu Lys Ser Gly Glu 
     130                135                140
Ala Thr Asp Gly Ala Arg Pro Gln Ala Leu Pro Glu Pro Met Gln Glu 
 145                150                155                160
Ser Lys Ala Glu Gly Asn Asn Gln Ala Pro Gly Glu Glu Glu Glu Glu 
                 165                170                175
Glu Glu Glu Ala Thr Asn Thr His Pro Pro Ala Ser Leu Pro Ser Gln 
             180                185                190
Lys Tyr Pro Gly Pro Gln Ala Glu Gly Asp Ser Glu Gly Leu Ser Gln 
         195                200                205
Gly Leu Val Asp Arg Glu Lys Gly Leu Ser Ala Glu Pro Gly Trp Gln 
     210                215                220
Ala Lys Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Glu Ala Gly 
 225                230                235                240
Glu Glu Ala Val Pro Glu Glu Glu Gly Pro Thr Val Val Leu Asn Pro 
                 245                250                255
His Pro Ser Leu Gly Tyr Lys Glu Ile Arg Lys Gly Glu Ser Arg Ser 
             260                265                270
Glu Ala Leu Ala Val Asp Gly Ala Gly Lys Pro Gly Ala Glu Glu Ala 
         275                280                285
Gln Asp Pro Glu Gly Lys Gly Glu Gln Glu His Ser Gln Gln Lys Glu 
     290                295                300
Glu Glu Glu Glu Met Ala Val Val Pro Gln Gly Leu Phe Arg Gly Gly 
 305                310                315                320
Lys Ser Gly Glu Leu Glu Gln Glu Glu Glu Arg Leu Ser Lys Glu Trp 
                 325                330                335
Glu Asp Ser Lys Arg Trp Ser Lys Met Asp Gln Leu Ala Lys Glu Leu 
             340                345                350
Thr Ala Glu Lys Arg Leu Glu Gly Gln Glu Glu Glu Glu Asp Asn Arg 
         355                360                365
Asp Ser Ser Met Lys Leu Ser Phe Arg Ala Arg Ala Tyr Gly Phe Arg 
     370                375                380
Gly Pro Gly Pro Gln Leu Arg Arg Gly Trp Arg Pro Ser Arg Glu Glu 
 385                390                395                400
Asp Ser Leu Glu Ala Gly Leu Pro Leu Gln Val Arg Gly Tyr Pro Glu 
                 405                410                415
Glu Lys Lys Glu Glu Glu Gly Ser Ala Asn Arg Arg Pro Glu Asp Gln 
             420                425                430
Glu Leu Glu Ser Leu Ser Ala Ile Glu Ala Glu Leu Glu Lys Val Ala 
         435                440                445
His Gln Leu Gln Ala Leu Arg Arg Gly 
     450                455



<210> 9278
<211> 743
<212> DNA
<213> Rattus norvegicus
<308> X06889
<400> 9278

tcggcttct  ctggggccc  gtcgccagc  cagtcgcca  ggtccgtgt  gccagcttg  60
ctcagttta  agagggcaa  atggcctca  ccacagact  tcgatatgg  cagaaggag  120
cctcagacc  gaacttcga  tatatgttc  agatcctga  cattggtaa  agcagtgtg  180
gcaaaacct  attcctttt  cgctacgca  acgactctt  tactccagc  tttgtcagc  240
ctgtgggca  agacttcaa  gtcaaaacc  tctaccgca  tgacaagag  atcaagctg  300
agatctggg  cacagcagg  caagagcgg  accgaacca  caccacagc  tactaccgg  360
gcgccatgg  cttcattct  atgtatgac  tcaccaatg  ggagtcctt  aatgcagtg  420
aggactggt  cactcagat  aaaacttac  catgggaca  tgcccaggt  ctgctggtg  480
ggaacaagt  cgacatgga  gacgagcga  tggtgtcct  agaacgagg  cggcagctg  540
ccgaccacc  gggctttga  ttctttgag  ccagcgcca  ggacaacat  aatgtcaag  600
agacctttg  acgtctggt  gacgtgatc  gtgagaaga  gtcggagtc  ctagatact  660
cagaccttg  agtcacggg  gccaagcag  gcccacagc  caccgacca  caggcacca  720
ctcatcagg  ttgcgcctg  tga  743



<210> 9279
<211> 220
<212> PRT
<213> Rattus norvegicus
<308> P05713
<400> 9279

Met Ala Ser Ala Thr Asp Ser Arg Tyr Gly Gln Lys Glu Ser Ser Asp 
  1               5                  10                  15
Gln Asn Phe Asp Tyr Met Phe Lys Ile Leu Ile Ile Gly Asn Ser Ser 
             20                  25                  30
Val Gly Lys Thr Ser Phe Leu Phe Arg Tyr Ala Asp Asp Ser Phe Thr 
         35                  40                  45
Pro Ala Phe Val Ser Thr Val Gly Ile Asp Phe Lys Val Lys Thr Ile 
     50                  55                  60
Tyr Arg Asn Asp Lys Arg Ile Lys Leu Gln Ile Trp Asp Thr Ala Gly 
 65                  70                  75                  80
Gln Glu Arg Tyr Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly Ala Met 
                 85                  90                  95
Gly Phe Ile Leu Met Tyr Asp Ile Thr Asn Glu Glu Ser Phe Asn Ala 
             100                105                110
Val Gln Asp Trp Ser Thr Gln Ile Lys Thr Tyr Ser Trp Asp Asn Ala 
         115                120                125
Gln Val Leu Leu Val Gly Asn Lys Cys Asp Met Glu Asp Glu Arg Val 
     130                135                140
Val Ser Ser Glu Arg Gly Arg Gln Leu Ala Asp His Leu Gly Phe Glu 
 145                150                155                160
Phe Phe Glu Ala Ser Ala Lys Asp Asn Ile Asn Val Lys Gln Thr Phe 
                 165                170                175
Glu Arg Leu Val Asp Val Ile Cys Glu Lys Met Ser Glu Ser Leu Asp 
             180                185                190
Thr Ala Asp Pro Ala Val Thr Gly Ala Lys Gln Gly Pro Gln Leu Thr 
         195                200                205
Asp Gln Gln Ala Pro Pro His Gln Asp Cys Ala Cys 
     210                215                220



<210> 9280
<211> 777
<212> DNA
<213> Homo sapiens
<308> M28210
<400> 9280

gaattccgc  tagtcgccg  tgcatcggt  cagggcaag  tggcatcgg  cacagactc  60
cgctatggg  agaaggagt  ctcggatca  aacttcgac  acatgttca  gattctcat  120
atcggcaac  gcagcgtgg  caagacgtc  ttcctcttc  gctatgctg  cgactcgtt  180
acgcctgcc  tcgtcagca  cgtgggcat  gacttcaag  tcaagacca  ctatcgcaa  240
gacaagagg  tcaagctgc  gatctggga  acagcaggg  aagagcggt  ccggaccat  300
accaccgca  actaccggg  cgccatggg  ttcatcctc  tgtatgaca  caccaacga  360
gaatccttc  atgcagtgc  ggactggtc  acccagatc  agacctact  atgggacaa  420
gcccaggtg  tgctggtag  aaacaagtg  gacatggag  atgagcggg  ggtgtcatc  480
gaacgtggc  ggcagctag  tgaccacct  gggttcgag  tctttgagg  aagcgccaa  540
gacaacatt  acgtcaagc  gacctttga  cgcctggtg  atgtcatct  cgagaagat  600
tccgagtcg  tggacacgg  ggaccctgc  gtcacaggc  ccaagcagg  cccacagct  660
agtgaccag  aggtgccac  gcaccagga  tgcgcctgc  gagagccat  ccactccct  720
tcccctctt  cctgtcttc  ccaccttcc  gcaactgac  cggcctgac  cggcccc  777



<210> 9281
<211> 220
<212> PRT
<213> Homo sapiens
<308> P20336
<400> 9281

Met Ala Ser Ala Thr Asp Ser Arg Tyr Gly Gln Lys Glu Ser Ser Asp 
  1               5                  10                  15
Gln Asn Phe Asp Tyr Met Phe Lys Ile Leu Ile Ile Gly Asn Ser Ser 
             20                  25                  30
Val Gly Lys Thr Ser Phe Leu Phe Arg Tyr Ala Asp Asp Ser Phe Thr 
         35                  40                  45
Pro Ala Phe Val Ser Thr Val Gly Ile Asp Phe Lys Val Lys Thr Ile 
     50                  55                  60
Tyr Arg Asn Asp Lys Arg Ile Lys Leu Gln Ile Trp Asp Thr Ala Gly 
 65                  70                  75                  80
Gln Glu Arg Tyr Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly Ala Met 
                 85                  90                  95
Gly Phe Ile Leu Met Tyr Asp Ile Thr Asn Glu Glu Ser Phe Asn Ala 
             100                105                110
Val Gln Asp Trp Ser Thr Gln Ile Lys Thr Tyr Ser Trp Asp Asn Ala 
         115                120                125
Gln Val Leu Leu Val Gly Asn Lys Cys Asp Met Glu Asp Glu Arg Val 
     130                135                140
Val Ser Ser Glu Arg Gly Arg Gln Leu Ala Asp His Leu Gly Phe Glu 
 145                150                155                160
Phe Phe Glu Ala Ser Ala Lys Asp Asn Ile Asn Val Lys Gln Thr Phe 
                 165                170                175
Glu Arg Leu Val Asp Val Ile Cys Glu Lys Met Ser Glu Ser Leu Asp 
             180                185                190
Thr Ala Asp Pro Ala Val Thr Gly Ala Lys Gln Gly Pro Gln Leu Ser 
         195                200                205
Asp Gln Gln Val Pro Pro His Gln Asp Cys Ala Cys 
     210                215                220



<210> 9282
<211> 2288
<212> DNA
<213> Rattus norvegicus
<308> X06942
<400> 9282

gcggtagcg  gtgacagga  gcctatggc  cctgcccag  cctacctca  cccatcttg  60
aaaaatcct  agacaacat  gaaccacca  gaggccctc  tgctagtgg  gctgagcca  120
ctcgggcag  tggcactgt  aaagtgtac  tgcctaaca  gcaacgcac  gtggtgact  180
tccgggatg  catgagtgt  tatgactct  tggacaagg  cctcaaggt  cggggtctc  240
atcaggact  ctgtgtggt  tacagactc  tcaaaggaa  aaagacagt  actgcctgg  300
acacagcca  tgcacctct  gatggcgag  agctcattg  ggaggtcct  gaagatgtg  360
cactgacca  gcacaattt  gtacggaag  cattcttca  tttggcctt  tgtgacttc  420
gccttaagt  tctgttcca  ggctttcgc  gccaaacct  tggctacaa  ttccaccag  480
attgttcct  caaggtccc  acggtctgc  ttgacatga  taccaaccg  cgacagttc  540
accacagca  ccaggattt  tctggaggc  ccaggcagc  ggaggttcc  tcaaatctc  600
ctgtgaatg  gctgctaac  ccccagggt  ccagtccct  tacccagca  cgtgaccag  660
agcacttct  cttccctgc  cctgccaat  ccccactgc  gcgcatccg  tccacatct  720
ctcctaacg  ccacatggt  agcaccaca  ctcccatgg  ctccagcct  atgcagttt  780
ctgctcaga  cttcagcac  gatgctgct  gtagaggtg  tgatggagc  cctcggggt  840
gccctagcc  agctagtgt  tcttcaggg  ggaagtccc  acattccaa  ttacctgca  900
aacagcggg  acggaagtc  ttggcagat  aaaagaaaa  agtgaagaa  ctggggtac  960
gggactcag  ctattactg  gaggtgcca  ccagtgagg  acagctgtt  aagaggatc  1020
ggacaggct  ttttggcac  gtgtttcgg  ggcgttggc  tggcgatgt  gctgtgaaa  1080
tgctcaagg  ggcccaacc  accgctgag  aggcccagg  cttcaagaa  gagatgcag  1140
tgctcagga  gacacgaca  gtcaacatt  tgctgttta  gggtttcat  actcggcca  1200
ggtttgcca  catcacaca  tggtgtgag  gttccagcc  ctaccacca  ctacatgtg  1260
ctgacacgc  ctttgacat  gtccagctc  ttgatgtgg  ccggcagac  gcccagggc  1320
tggactacc  ccacgccaa  aacatcatt  accgagacc  aaagtccaa  aatatcttc  1380
tacatgagg  gctcacagt  aagattggt  acttcggcc  ggccacagt  aagacacga  1440
ggagtgggg  ccagccctt  gagcagccc  cagggtctg  gctgtggat  gcagctgag  1500
tgatccgaa  gcaggaccc  aacccctac  gcttccagt  ggatgtcta  gcctatggt  1560
ttgtgctct  tgagcttat  accggctca  tgccctaca  ccacattgg  agccgtgac  1620
agatcatct  tatggtggg  cgtggctat  tgtctccgg  cctcagcaa  atcttcagt  1680
attgcccca  agccatgag  cgcttgctg  ctgactgcc  caagttcca  cgggaggag  1740
ggcctctat  tccccagat  ctggccacg  tcgagctgc  gcagcggtc  ctccccaag  1800
ttgagcgga  tgcctccga  ccctccttg  accgtaccc  ggctgatga  ttgcctgcc  1860
gccttctca  cgcagcccg  cttgtgcct  agactccac  cccagccca  tagggagcc  1920
ttttcagct  accatgcca  ggcaccccc  tcctaccag  caatcattg  tctgtctgt  1980
ccctgatac  gcctcagga  tccctatcc  acaccctgg  aaatttggg  gactccaaa  2040
actgaggtc  cctgcttcc  ccataattt  gtctcctct  ggctttggg  atagttcta  2100
tttggagag  tgttttacc  ccaatggct  ggattcagt  caaagattc  actcggaac  2160
tctttataa  gttttcgcc  gacatgtct  cactgaatt  tggggttcc  agcacccca  2220
gcggatttg  gagtttccc  ttgtctccc  ccactattc  aggactctc  tctttacca  2280
gaagcaca  2288



<210> 9283
<211> 604
<212> PRT
<213> Rattus norvegicus
<308> P14056
<400> 9283

Met Glu Pro Pro Arg Gly Pro Pro Ala Ser Gly Ala Glu Pro Ser Arg 
  1               5                  10                  15
Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val 
             20                  25                  30
Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
         35                  40                  45
Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
     50                  55                  60
Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro 
 65                  70                  75                  80
Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                 85                  90                  95
Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys 
             100                105                110
Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys 
         115                120                125
Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys 
     130                135                140
Val Asp Met Ser Thr Asn Arg Arg Gln Phe Tyr His Ser Ile Gln Asp 
 145                150                155                160
Leu Ser Gly Gly Ser Arg Gln Gln Glu Val Pro Ser Asn Leu Ser Val 
                 165                170                175
Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Phe Thr Gln Gln Arg 
             180                185                190
Asp Gln Glu His Phe Ser Phe Pro Ala Pro Ala Asn Pro Pro Leu Gln 
         195                200                205
Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr 
     210                215                220
Ala Pro Met Asp Ser Ser Leu Met Gln Phe Thr Ala Gln Ser Phe Ser 
 225                230                235                240
Thr Asp Ala Ala Gly Arg Gly Gly Asp Gly Ala Pro Arg Gly Ser Pro 
                 245                250                255
Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser Lys Leu 
             260                265                270
Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Glu Lys Lys Lys 
         275                280                285
Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr Tyr Trp Glu Val Pro 
     290                295                300
Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Thr Gly Ser Phe Gly 
 305                310                315                320
Thr Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys Val Leu 
                 325                330                335
Lys Val Ala Gln Pro Thr Ala Glu Gln Ala Gln Ala Phe Lys Asn Glu 
             340                345                350
Met Gln Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu Phe Met 
         355                360                365
Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile Thr Gln Trp Cys Glu 
     370                375                380
Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Thr Arg Phe Asp 
 385                390                395                400
Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr Ala Gln Gly Met Asp 
                 405                410                415
Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser Asn Asn 
             420                425                430
Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile Gly Asp Phe Gly Leu 
         435                440                445
Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln Pro Leu Glu Gln Pro 
     450                455                460
Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met Gln Asp 
 465                470                475                480
Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly Val Val 
                 485                490                495
Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr Ser His Ile Gly Ser 
             500                505                510
Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser Pro Asp 
         515                520                525
Leu Ser Lys Ile Phe Ser Asn Cys Pro Lys Ala Met Arg Arg Leu Leu 
     530                535                540
Thr Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe Pro Gln 
 545                550                555                560
Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys Ile Glu 
                 565                570                575
Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr Gln Ala Asp Glu Leu 
             580                585                590
Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro 
         595                600



<210> 9284
<211> 2458
<212> DNA
<213> Homo sapiens
<308> X04790
<400> 9284

tgacccaat  agggtggaa  gctgagtcc  gcagagcca  taacgagag  ccgagaggc  60
acggaggcg  actctgtga  gaaacaaga  gagaggccc  agatggaga  ggcggcggc  120
gtagcggcg  gacaggagc  ccatggcac  tgcccagcc  cacctcagc  catcttgac  180
aaatctaag  ctccatgga  ccaccacgg  gcccccctg  caatggggc  gagccatcc  240
gggcagtgg  caccgtcaa  gtatacctg  ccaacaagc  acgcacggt  gtgactgtc  300
gggatggca  gagtgtcta  gactctcta  acaaggccc  gaaggtgcg  ggtctaaat  360
aggactgct  tgtggtcta  cgactcatc  agggacgaa  gacggtcac  gcctgggac  420
cagccattg  tcccctgga  ggcgaggag  tcattgtcg  ggtccttga  gatgtcccg  480
tgaccatgc  caattttgt  cggaagacc  tcttcagcc  ggcgttctg  gacttctgc  540
ttaagtttc  gttccatgg  ttccgttgc  aaacctgtg  ctacaagtt  caccagcat  600
gttcctcca  ggtccccac  gtctgtgtt  acatgagta  caaccgcca  cagttctac  660
acagtgtcc  ggatttgtc  ggaggctcc  gacagcatg  ggctccctc  aaccgcccc  720
tgaatgagt  gctaacccc  cagggtccc  gcccccgca  ccagcactg  gacccggag  780
acttcccct  ccctgcccc  gccaatgcc  ccctacagc  catccgctc  acgtccact  840
ccaacgtcc  tatggtcag  accacggcc  ccatggact  caacctcat  cagctcact  900
gccagagtt  cagcactga  gctgccggt  gtagaggag  tagtgatgg  accccccgg  960
ggagcccca  cccagccag  gtgtcctcg  ggaggaagt  cccacattc  aagtcacca  1020
cagagcagc  cgagcggaa  tccttggcc  atgacaaga  gaaagtgaa  aacctgggg  1080
accgggant  aggctatta  tgggaggta  cacccagtg  ggtgcagct  ctgaagagg  1140
tcgggacgg  ctcgtttgg  accgtgttt  gagggcggt  gcatggcga  gtggccgtg  1200
aggtgctca  ggtgtccca  cccacagct  agcaggccc  ggctttcaa  aatgagatg  1260
aggtgctca  gaagacgcg  catgtcaac  tcttgctgt  tatgggctt  atgacccgg  1320
cgggatttg  catcatcac  cagtggtgt  agggctcca  cctctacca  cacctgcat  1380
tggccgaca  acgcttcga  atggtccag  tcatcgacg  ggcccggca  actgcccag  1440
gcatggact  cctccatgc  aagaacatc  tccaccgag  tctcaagtc  aacaacatc  1500
tcctacatg  ggggctcac  gtgaagatc  gtgactttg  cttggccac  gtgaagact  1560
gatggagcg  ggcccagcc  ttggagcag  cctcaggat  tgtgctgtg  atggcagct  1620
aggtgatcc  tatgcagga  ccgaacccc  acagcttcc  gtcagacgt  tatgcctac  1680
gggttgtgc  ctacgagct  atgactggc  cactgcctt  cagccacat  ggctgccgt  1740
accagatta  ctttatggt  ggccgtggc  atctgtccc  ggacctcag  aaaatctcc  1800
gcaactgcc  caaggccat  cggcgcctg  tgtctgact  cctcaagtt  cagcgggag  1860
agcggcccc  cttccccca  atcctggcc  caattgagc  gctgcaacg  tcactcccc  1920
agattgagc  gagtgcctc  gaaccctcc  tgcaccgca  ccaggccga  gagttgcct  1980
cctgcctac  cagcgcagc  cgccttgtg  cttaggccc  gcccaagcc  ccagggagc  2040
aatctcagc  ctccacgcc  aggagcctt  cccaccagc  aatcaatgt  cgtctctgc  2100
ctgatgctg  ctcaggatc  cccattccc  accctggga  atgaggggg  ccccatgtg  2160
ttttccagt  cttctggaa  tgggggacc  ccgccaaag  ctgagcccc  tgtctcctc  2220
atcatttgg  ttcctcttg  ctttgggga  acttctaaa  tttgggagc  cctccatct  2280
caatggctg  gatttgtgg  agggattcc  ctcagaacc  ctctggaat  tgtgcctga  2340
gtgccttcc  ctggatttt  gggttccca  caccccatg  ggattttgg  gggtccctt  2400
tgtgtctcc  ccgccattc  aggactcct  tctttcttc  ccaagaagc  cagaattc  2458



<210> 9285
<211> 606
<212> PRT
<213> Homo sapiens
<308> P10398
<400> 9285

Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
  1               5                  10                  15
Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val 
             20                  25                  30
Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
         35                  40                  45
Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
     50                  55                  60
Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro 
 65                  70                  75                  80
Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                 85                  90                  95
Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys 
             100                105                110
Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys 
         115                120                125
Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys 
     130                135                140
Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp 
 145                150                155                160
Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu 
                 165                170                175
Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr Gln His Cys 
             180                185                190
Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala Pro Leu Gln 
         195                200                205
Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr 
     210                215                220
Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln Ser Phe Ser 
 225                230                235                240
Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr Pro Arg Gly 
                 245                250                255
Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser 
             260                265                270
Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Asp Lys 
         275                280                285
Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr Tyr Trp Glu 
     290                295                300
Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Thr Gly Ser 
 305                310                315                320
Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys 
                 325                330                335
Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln Ala Phe Lys 
             340                345                350
Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu 
         355                360                365
Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile Thr Gln Trp 
     370                375                380
Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Thr Arg 
 385                390                395                400
Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr Ala Gln Gly 
                 405                410                415
Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser 
             420                425                430
Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile Gly Asp Phe 
         435                440                445
Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln Pro Leu Glu 
     450                455                460
Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met 
 465                470                475                480
Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly 
                 485                490                495
Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr Ser His Ile 
             500                505                510
Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser 
         515                520                525
Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala Met Arg Arg 
     530                535                540
Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe 
 545                550                555                560
Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys 
                 565                570                575
Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr Gln Ala Asp 
             580                585                590
Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro 
         595                600                605



<210> 9286
<211> 2971
<212> DNA
<213> Rattus norvegicus
<308> X07266
<400> 9286

cggcggccg  gtgcgaggc  gagagcgag  tctgtacgg  gtgcgagcg  gggcgatca  60
agcctgcga  caagcaaag  aagagagcg  gtgagcggc  aggcgcctg  gcgatgctc  120
ggcccctga  cccgcggcc  tgagctagc  gggacggac  tgcgcggga  ggcgccgcg  180
ggccccgct  ccctggggg  atgaaagct  ctggttgac  taagagcac  tggccttca  240
agattcgtg  ccatcccag  gtgggcaca  tgtcaacag  aggagttgc  gctcaggat  300
ttcgagtcc  attaaaaac  ggatttctc  ataatggcc  ggctttggg  aatatgaag  360
cctgctggg  cagtcgcaa  gagtttgaa  agaattttt  aaatatcga  ccaataacc  420
tggcctaca  tctgaactc  cctgctccg  agcatctaa  aaccctcgg  tgtgcttct  480
cgtccgctc  agggagcgg  cacttcttt  cagagcgtg  tccatctcc  aagtcaagc  540
tgccccctc  tgttatccc  ccaagtgaa  gctcgggac  gcgtgaaga  gatcaagtt  600
tgtgtggtt  taagaaact  tcagtgaat  gggtgtgcg  ttccacacc  ccacttaca  660
ccattcaaa  ctgctcttc  ccgtttccc  gtgcagctc  ctgtgatcg  agttcccga  720
cgctcccac  attgcccat  tctgaggac  catctctgg  tgaggccga  tgtgaggtg  780
aatttctaa  cagtgcaga  acagacttc  ttttagaag  ctgcgtgcc  tccgatttc  840
aatacgatg  tcctggcag  cgaagcttc  gtgggtgcg  acagatcaa  tatgcgtat  900
ttgacagcc  aactgtttc  gtggcagat  ttagctgtg  atctgacca  aacagagtt  960
ttccagatc  aaaccctcc  ccgcctcaa  gccatcgca  attaaggag  tctcactca  1020
gaccagccg  gtcgtttaa  aagccagcc  tccggatat  tagctgcac  cacagagcc  1080
ctcctagct  ggatgaaga  aagcctgag  tcccgcccc  ggttcctat  cctcccagg  1140
cagccaagc  agactacag  aggtggtca  cagaagtga  ctctaacac  tacagtgat  1200
aagataggc  tcccaaagt  cccccgaga  aacctttgt  tcggagtaa  tcccgtacc  1260
caagtccta  aagccttcc  tcttacctc  atggggtca  gcctccaac  cagagcttt  1320
cccccgacc  caagtatgt  agcagcaaa  ccctgcaga  acagagcag  gaagggtct  1380
ccaaggccc  ctgcatcct  cccatcatt  agaatggga  gaaggtcag  tccacgcat  1440
attacctac  acctgagag  ccgccatac  ttgacaaat  tgagaagta  tttagggaa  1500
cagaagaag  aaacccaag  acccagatt  agccattac  tgctgcctg  ggtatggtc  1560
ctgccacag  caagctggc  tccagaatg  aaatggatg  gggcggcca  gggaagcgc  1620
aacacttat  ctacgtggt  tctccgtag  tatggggtc  tggttcaac  gaagttaca  1680
ggaacggat  gctgccaag  ttccaattt  aggttcata  aacagtgtc  agtggcaac  1740
tgaagtggt  gactctgcc  tggtgagga  ggcatagag  cgttatgag  tgctgttgt  1800
ctgggagtc  ctgacctat  agcatagga  gaaaaaagt  tgatttaaa  atgtgctag  1860
gggacactt  tacatttga  tacattata  acctatgta  aaacgtgcg  tgtaaccat  1920
gaccatagc  gcaggataa  caattagtc  ctctagagt  atctatatt  agaacaatt  1980
aaacgagct  gaggcacag  tccagacag  gtgaaaatt  agcaaacgg  agagagcag  2040
actgttgat  agttataaa  gtagagatt  ctggcattc  ggcctgcta  ctagtttgt  2100
ttcttcccc  tccctgcca  cagtcttct  catacacga  agggcgtgc  cttcgccag  2160
cctgtaacg  cttgttgaa  tcgttctat  gcctaatac  tgccgctct  ggcgtttgt  2220
ttgagagga  aggacagcc  tttctggac  atgttatct  tcacctgtg  atgtctctc  2280
tggaaatgg  cagaattgg  gacttttcc  tgctattcc  gcttttccc  tccactgaa  2340
aggctttca  gagtgcagt  gagtggtgc  ggccgtcag  gttgggtat  agttttata  2400
accagccca  tgattagcc  tgattgaga  ttatcgtgg  gtgtatggg  tgttgtttt  2460
tttttgaga  tttaaagta  aacacaagc  ggtcttgtg  tgttggttc  tattcagta  2520
ttcctgggg  ttgtttgct  tttaagtga  acacttctg  ccaatagca  agaacgtct  2580
aatgccaga  gtcacttca  catcttcct  cttagaaaa  tcacagctg  ctgcctcac  2640
gccctgaga  tcagtgaga  gcatagctt  tgttcaatt  ttacatcct  tgattgttt  2700
tcttgtata  ataagcaca  agagaaggt  cttgctaac  gagggacac  gctgccatg  2760
cccaacaag  tgttcagtt  aaactgctg  atgacatta  ttgagctat  taaagctta  2820
ttttagtat  aactaaatg  aggttaaaa  atgctttag  aaatgcact  atctccgca  2880
tgtgtgtac  gtattggac  aaggatttg  tcattttgt  gcattattt  gaatattgt  2940
ttttcattt  aataaagtt  tattactta  t  2971



<210> 9287
<211> 459
<212> PRT
<213> Rattus norvegicus
<308> CAA30252
<400> 9287

Met Ser Thr Ala Gly Val Ala Ala Gln Asp Ile Arg Val Pro Leu Lys 
  1               5                  10                  15
Thr Gly Phe Leu His Asn Gly Gln Ala Leu Gly Asn Met Lys Thr Cys 
             20                  25                  30
Trp Gly Ser Arg Asn Glu Phe Glu Lys Asn Phe Leu Asn Ile Asp Pro 
         35                  40                  45
Ile Thr Met Ala Tyr Asn Leu Asn Ser Pro Ala Pro Glu His Leu Thr 
     50                  55                  60
Thr Leu Gly Cys Ala Ser Pro Ser Ala Pro Gly Ser Gly His Phe Phe 
 65                  70                  75                  80
Ala Glu Arg Gly Pro Ser Pro Lys Ser Ser Leu Pro Pro Leu Val Ile 
                 85                  90                  95
Pro Pro Ser Glu Ser Ser Gly Gln Arg Glu Glu Asp Gln Val Leu Cys 
             100                105                110
Gly Phe Lys Lys Leu Ser Val Asn Gly Val Cys Ala Ser Thr Pro Pro 
         115                120                125
Leu Thr Pro Ile Gln Ser Cys Ser Ser Pro Phe Pro Cys Ala Ala Pro 
     130                135                140
Cys Asp Arg Ser Ser Arg Pro Leu Pro Pro Leu Pro Ile Ser Glu Asp 
 145                150                155                160
Pro Ser Leu Asp Glu Ala Asp Cys Glu Val Glu Phe Leu Thr Ser Ala 
                 165                170                175
Asp Thr Asp Phe Leu Leu Glu Asp Cys Val Pro Ser Asp Phe Lys Tyr 
             180                185                190
Asp Val Pro Gly Arg Arg Ser Phe Arg Gly Cys Gly Gln Ile Asn Tyr 
         195                200                205
Ala Tyr Phe Asp Ser Pro Thr Val Ser Val Ala Asp Leu Ser Cys Ala 
     210                215                220
Ser Asp Gln Asn Arg Val Val Pro Asp Pro Asn Pro Pro Pro Pro Gln 
 225                230                235                240
Ser His Arg Arg Leu Arg Arg Ser His Ser Gly Pro Ala Gly Ser Phe 
                 245                250                255
Asn Lys Pro Ala Ile Arg Ile Ser Ser Cys Thr His Arg Ala Ser Pro 
             260                265                270
Ser Ser Asp Glu Asp Lys Pro Glu Ile Pro Pro Arg Val Pro Ile Pro 
         275                280                285
Pro Arg Pro Ala Lys Pro Asp Tyr Arg Arg Trp Ser Ala Glu Val Thr 
     290                295                300
Ser Asn Thr Tyr Ser Asp Glu Asp Arg Pro Pro Lys Val Pro Pro Arg 
 305                310                315                320
Glu Pro Leu Ser Arg Ser Asn Ser Arg Thr Pro Ser Pro Lys Ser Leu 
                 325                330                335
Pro Ser Tyr Leu Asn Gly Val Met Pro Pro Thr Gln Ser Phe Ala Pro 
             340                345                350
Asp Pro Lys Tyr Val Ser Ser Lys Ala Leu Gln Arg Gln Ser Ser Glu 
         355                360                365
Gly Ser Ala Lys Ala Pro Cys Ile Leu Pro Ile Ile Glu Asn Gly Lys 
     370                375                380
Lys Val Ser Ser Thr His Tyr Tyr Leu Leu Pro Glu Arg Pro Pro Tyr 
 385                390                395                400
Leu Asp Lys Tyr Glu Lys Tyr Phe Arg Glu Ala Glu Glu Ala Asn Pro 
                 405                410                415
Ser Thr Gln Ile Gln Pro Leu Pro Ala Ala Cys Gly Met Val Ser Ala 
             420                425                430
Thr Asp Lys Leu Ala Ser Arg Met Lys Met Asp Val Gly Gly His Gly 
         435                440                445
Lys Arg Lys His Leu Ser Tyr Val Val Ser Pro 
     450                455



<210> 9288
<211> 3099
<212> DNA
<213> Homo sapiens
<308> NM_018948
<400> 9288

tgcgaggca  agtgctagc  ggagcgcga  ccagcaaga  gcgcctgcg  gatgtccgg  60
cccctgagc  cgcggcgct  agccagccg  gacggacat  cgcgggagg  cgccgcggg  120
cagccgccg  tcctccggg  gaatgaaag  tactggttg  ttttaaagt  cctgggcct  180
acaggtttg  agatgtccc  gaataaggc  caatgtcaa  agcaggagt  gctgctcag  240
agatcagag  cccattaaa  actggattt  tacataatg  ccgagccat  gggaatatg  300
ggaagacct  ctggagcag  cgcagtgag  ttaaaaaca  ctttttaaa  attgacccg  360
taaccatgg  ctacagtct  aactcttct  ctcaggagc  cctaatacc  cttgggcat  420
cttccaaat  tgctccgat  aatggccac  gctttgcag  aaatggtcc  tctcaaaag  480
ccagcttgc  ccctcttct  attccccca  gtgaaaact  gggaccaca  gaagaggat  540
aagttgtat  tggttttaa  aaactcaca  tgaatgggg  ttgtgcttc  acccctcca  600
tgacaccca  aaaaaactc  ccttccctt  tcccctgtg  ccctctttg  gaacggggt  660
ctaggcctc  tccaccgtt  ccaatctct  aagccctct  tctggatga  acagactgt  720
aggtggaat  cctaactag  tcagataca  acttccttt  agaagactc  acactttct  780
atttcaaat  tgatgttcc  ggcaggcga  gcttccgtg  gtgtggaca  atcaactat  840
catattttg  taccccagc  gtttctgca  cagatctca  ctatgtgtc  gaccaaaat  900
gaggtgtcc  agatccaaa  cctcctcca  ctcagaccc  ccgaagatt  agaaggtct  960
attcgggac  agctggctc  tttaacaag  cagccataa  gatatccaa  tgttgtata  1020
acagagctt  tcctaactc  gatgaagac  aacctgagg  tccccccag  gttcccata  1080
ctcctagac  agtaaagcc  gattataga  gatggtcag  agaagttac  tcgagcacc  1140
atagtgatg  agacaggcc  cccaaagta  cgccaagag  acctttgtc  ccgagtaac  1200
cgcgcacac  gagtcccaa  agccttccg  cttacctca  tggggtcat  cccccgaca  1260
agagctttg  ccctgatcc  aagtatgtc  gcagcaaag  actgcaaag  cagaacagc  1320
aaggatctg  cagtaaggt  ccttgcatt  tgcccatta  tgaaaatgg  aagaaggtt  1380
gttcaacac  ttattacct  ctacctgaa  gaccaccat  cctggacaa  tatgaaaaa  1440
tttttaggg  agcagaaga  acaaatgga  gcgcccaaa  ccagccatt  cctgctgac  1500
gcggtatat  ttcagccac  gaaaagcca  actcaaaaa  aaaaatgga  ctgggtggc  1560
acgtgaagc  taaacattt  tcctatgtg  tttctcctt  gaccttggg  tcatggttc  1620
gcagaggtt  cataggagc  aatggttct  aattttcca  tttgattga  gtgcagaga  1680
aaatccctt  gattgcaaa  taaaatagt  gaactctct  tcttcatgt  gaaggttta  1740
agcagttgt  agatgctgt  atgctgaga  accctgact  tgttagtgt  ggaaaaaag  1800
cttacaagt  tataattta  agatgtgat  gtggggagg  gaggatggg  aagcttttt  1860
tatatgcat  cattacata  ctatatata  acttgtggt  taaccatag  ccatagctg  1920
aggttaacc  attagttac  atcgtagag  aatatatat  cagaataat  aactcaagc  1980
ggagaaatg  gtcctgata  actgaaaat  gagcaaatg  aagaagata  agtattgtt  2040
agatcagaa  cattaaaaa  tatttttgt  tagtaagtt  gaagatttc  ggcttttag  2100
ccttttcta  tttgttcca  ttatttttg  aggcaatct  ttccatgga  ggcagggta  2160
ccattcttt  ccatgggtg  acctgctta  gttaaaaat  ataccaagg  ctcatactt  2220
caggtttca  gttgcgtct  gttgaggga  ggagagcag  ttacttggc  accatattg  2280
cacctgtac  tgtcacaca  cttgaaaaa  aaaacgata  tagaactag  gactaattt  2340
cccttacag  tcctgcttg  tcccaccca  tgaagtagc  catcgtagt  cgggccgta  2400
tagaagcag  ggggtacgt  agactcaga  ggaaaagta  tctaggtgc  agtgttagg  2460
tgtcagttt  acaaaataa  gaagcaatt  gctatgtga  tgagagtta  tgtttgggg  2520
tgtgtgttg  ggttttgct  ttttttttt  agactgtat  aataaacat  caacacaag  2580
tggccttgt  ttgctggtt  ctattcagt  tttcctggg  attgtttgc  ttttaagta  2640
aacacttct  acccatagc  cagtatgtc  gaattccag  ggtcacatc  gcatctttc  2700
gctttgaaa  ctctcacag  tgtggctgc  tcacttaga  gcagtgaga  acatagttg  2760
tgttccgat  ttcacatcc  tccatgtat  tatcttgaa  agataagca  agaagagaa  2820
gtgctcact  acagaggta  attactgca  tgttctctt  acagttaaa  aagctgttt  2880
cagtttaaa  tgctgaata  tatttgagc  atttaaagc  tattatatt  tagtatgaa  2940
taaatgaag  ttaaaacat  cttaagaaa  atgcactga  ttctgcatt  tgtgtacag  3000
attggacaa  ggattttat  cattttgtt  cattatttt  aatattgtc  tttcatttt  3060
ataaagtta  aatacttaa  aaaaaaaaa  aaaaaaaaa  3099



<210> 9289
<211> 462
<212> PRT
<213> Homo sapiens
<308> NP_061821
<400> 9289

Met Ser Ile Ala Gly Val Ala Ala Gln Glu Ile Arg Val Pro Leu Lys 
  1               5                  10                  15
Thr Gly Phe Leu His Asn Gly Arg Ala Met Gly Asn Met Arg Lys Thr 
             20                  25                  30
Tyr Trp Ser Ser Arg Ser Glu Phe Lys Asn Asn Phe Leu Asn Ile Asp 
         35                  40                  45
Pro Ile Thr Met Ala Tyr Ser Leu Asn Ser Ser Ala Gln Glu Arg Leu 
     50                  55                  60
Ile Pro Leu Gly His Ala Ser Lys Ser Ala Pro Met Asn Gly His Cys 
 65                  70                  75                  80
Phe Ala Glu Asn Gly Pro Ser Gln Lys Ser Ser Leu Pro Pro Leu Leu 
                 85                  90                  95
Ile Pro Pro Ser Glu Asn Leu Gly Pro His Glu Glu Asp Gln Val Val 
             100                105                110
Cys Gly Phe Lys Lys Leu Thr Val Asn Gly Val Cys Ala Ser Thr Pro 
         115                120                125
Pro Leu Thr Pro Ile Lys Asn Ser Pro Ser Leu Phe Pro Cys Ala Pro 
     130                135                140
Leu Cys Glu Arg Gly Ser Arg Pro Leu Pro Pro Leu Pro Ile Ser Glu 
 145                150                155                160
Ala Leu Ser Leu Asp Asp Thr Asp Cys Glu Val Glu Phe Leu Thr Ser 
                 165                170                175
Ser Asp Thr Asp Phe Leu Leu Glu Asp Ser Thr Leu Ser Asp Phe Lys 
             180                185                190
Tyr Asp Val Pro Gly Arg Arg Ser Phe Arg Gly Cys Gly Gln Ile Asn 
         195                200                205
Tyr Ala Tyr Phe Asp Thr Pro Ala Val Ser Ala Ala Asp Leu Ser Tyr 
     210                215                220
Val Ser Asp Gln Asn Gly Gly Val Pro Asp Pro Asn Pro Pro Pro Pro 
 225                230                235                240
Gln Thr His Arg Arg Leu Arg Arg Ser His Ser Gly Pro Ala Gly Ser 
                 245                250                255
Phe Asn Lys Pro Ala Ile Arg Ile Ser Asn Cys Cys Ile His Arg Ala 
             260                265                270
Ser Pro Asn Ser Asp Glu Asp Lys Pro Glu Val Pro Pro Arg Val Pro 
         275                280                285
Ile Pro Pro Arg Pro Val Lys Pro Asp Tyr Arg Arg Trp Ser Ala Glu 
     290                295                300
Val Thr Ser Ser Thr Tyr Ser Asp Glu Asp Arg Pro Pro Lys Val Pro 
 305                310                315                320
Pro Arg Glu Pro Leu Ser Pro Ser Asn Ser Arg Thr Pro Ser Pro Lys 
                 325                330                335
Ser Leu Pro Ser Tyr Leu Asn Gly Val Met Pro Pro Thr Gln Ser Phe 
             340                345                350
Ala Pro Asp Pro Lys Tyr Val Ser Ser Lys Ala Leu Gln Arg Gln Asn 
         355                360                365
Ser Glu Gly Ser Ala Ser Lys Val Pro Cys Ile Leu Pro Ile Ile Glu 
     370                375                380
Asn Gly Lys Lys Val Ser Ser Thr His Tyr Tyr Leu Leu Pro Glu Arg 
 385                390                395                400
Pro Pro Tyr Leu Asp Lys Tyr Glu Lys Phe Phe Arg Glu Ala Glu Glu 
                 405                410                415
Thr Asn Gly Gly Ala Gln Ile Gln Pro Leu Pro Ala Asp Cys Gly Ile 
             420                425                430
Ser Ser Ala Thr Glu Lys Pro Asp Ser Lys Thr Lys Met Asp Leu Gly 
         435                440                445
Gly His Val Lys Arg Lys His Leu Ser Tyr Val Val Ser Pro 
     450                455                460



<210> 9290
<211> 1388
<212> DNA
<213> Rattus norvegicus
<308> X07320
<400> 9290

gaattcctg  cacttccat  caagagcct  caagaacct  actaggtgc  tgggatccc  60
tgagatcca  ctgaccatg  cccgggatg  ggccctccc  gactctcat  ctgcacaga  120
tttctatga  aactacgag  ccaaggaga  cctgggcag  ggagtcagc  gcgtggtca  180
gagatgcat  cacaaacct  cgtgccaag  atacgcagt  aaaatcatc  acatcaccg  240
cggaggaag  tttagctcc  aggaggtac  ggagcttcg  gaagccacc  tgaaggagg  300
ggacattct  cagaaggtc  caggacacc  caacatcat  cagctgaag  acacttacg  360
gaccaacac  ttcttcttc  tggtatttg  tctgatgaa  agaggggaa  tctttgact  420
tctcacaga  aaggtcacc  tgactgaga  ggaaaccag  aagatcatg  gggccctgc  480
ggaggtggt  tgcaccttg  acaaactca  cattgtcca  cgggacctg  agccggaga  540
catccttct  gatgacaac  tgaacatca  gctcactga  ttcgggttt  cctgccagc  600
gcagccagg  gagaagctc  gagaggttt  tgggactcc  agttatctg  cccccgaaa  660
catccagtg  tccatggac  aaggccatc  tggctatgg  aaggaggtg  acatgtgga  720
cacaggagt  atcatgtat  cgctgctgg  tggctcccc  cccttctgg  accggaagc  780
aatgctaat  ttgaggatg  tcatggatg  caaatacca  ttcggctca  cagagtggg  840
tgactactc  gataccgtg  aagacttgg  atctcgctt  ttggtggtg  aaccccagg  900
ccgctgctc  gcggaagag  ccttggcgc  tcctttctt  caggagtac  tggtggaag  960
ggtgcggca  ttcagccct  gagggaagt  caaggtcat  tgtctaact  tgctggcct  1020
ggtaaggat  tactaccag  accgtcggg  gaagccggt  accagggag  tcgtcatcc  1080
agaccccta  gccctacgg  cattgcgca  actcatcga  gcctatgct  tccgcatct  1140
cggccactg  gtgaagaaa  ggcaacagc  gaacagagc  gccctcttc  agaacacgc  1200
caaggcagt  ctcctctcc  tggctgagg  ggaggactt  tgaggggtg  cggggcaca  1260
gggagaaag  aaacagggt  cgcgccccc  gaactgtga  aagaggatg  ctcaaggag  1320
aggcttctg  aaaggagct  tgaccctac  ctgcactct  aaaggctcg  cactagatg  1380
gggaattc  1388



<210> 9291
<211> 387
<212> PRT
<213> Rattus norvegicus
<308> P13286
<400> 9291

Thr Arg Asp Glu Ala Leu Pro Asp Ser His Ser Ala Gln Asn Phe Tyr 
  1               5                  10                  15
Glu Asn Tyr Glu Pro Lys Glu Ile Leu Gly Arg Gly Val Ser Ser Val 
             20                  25                  30
Val Arg Arg Cys Ile His Lys Pro Thr Cys Gln Glu Tyr Ala Val Lys 
         35                  40                  45
Ile Ile Asp Ile Thr Gly Gly Gly Ser Phe Ser Ser Glu Glu Val Gln 
     50                  55                  60
Glu Leu Arg Glu Ala Thr Leu Lys Glu Val Asp Ile Leu Gln Lys Val 
 65                  70                  75                  80
Ser Gly His Pro Asn Ile Ile Gln Leu Lys Asp Thr Tyr Glu Thr Asn 
                 85                  90                  95
Thr Phe Phe Phe Leu Val Phe Asp Leu Met Lys Arg Gly Glu Leu Phe 
             100                105                110
Asp Tyr Leu Thr Glu Lys Val Thr Leu Thr Glu Lys Glu Thr Arg Lys 
         115                120                125
Ile Met Arg Ala Leu Leu Glu Val Val Cys Thr Leu His Lys Leu Asn 
     130                135                140
Ile Val His Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp Asp Asn 
 145                150                155                160
Met Asn Ile Lys Leu Thr Asp Phe Gly Phe Ser Cys Gln Leu Gln Pro 
                 165                170                175
Gly Glu Lys Leu Arg Glu Val Cys Gly Thr Pro Ser Tyr Leu Ala Pro 
             180                185                190
Glu Ile Ile Gln Cys Ser Met Asp Glu Gly His Pro Gly Tyr Gly Lys 
         195                200                205
Glu Val Asp Met Trp Ser Thr Gly Val Ile Met Tyr Thr Leu Leu Ala 
     210                215                220
Gly Ser Pro Pro Phe Trp His Arg Lys Gln Met Leu Met Leu Arg Met 
 225                230                235                240
Ile Met Asp Gly Lys Tyr Gln Phe Gly Ser Pro Glu Trp Asp Asp Tyr 
                 245                250                255
Ser Asp Thr Val Lys Asp Leu Val Ser Arg Phe Leu Val Val Gln Pro 
             260                265                270
Gln Asp Arg Cys Ser Ala Glu Glu Ala Leu Ala His Pro Phe Phe Gln 
         275                280                285
Glu Tyr Val Val Glu Glu Val Arg His Phe Ser Pro Arg Gly Lys Phe 
     290                295                300
Lys Val Ile Cys Leu Thr Val Leu Ala Ser Val Arg Ile Tyr Tyr Gln 
 305                310                315                320
Tyr Arg Arg Val Lys Pro Val Thr Arg Glu Ile Val Ile Arg Asp Pro 
                 325                330                335
Tyr Ala Leu Arg Pro Leu Arg Arg Leu Ile Asp Ala Tyr Ala Phe Arg 
             340                345                350
Ile Tyr Gly His Trp Val Lys Lys Gly Gln Gln Gln Asn Arg Ala Ala 
         355                360                365
Leu Phe Glu Asn Thr Pro Lys Ala Val Leu Leu Ser Leu Ala Glu Glu 
     370                375                380
Glu Asp Phe 
 385



<210> 9292
<211> 1377
<212> DNA
<213> Homo sapiens
<308> NM_006213
<400> 9292

ggccttcag  cctctgtgg  cccctctcc  cggggggct  tgggattct  gtcaagctc  60
ttcaagagc  tgcaagcac  taaccagcc  cccagagtt  cctcactga  gatctgagc  120
tgacccggg  cgaggcact  ccggactct  attctgcac  ggacttcta  gagaattat  180
agcccaaag  gatcctggg  aggggcgtt  gcagtgtgg  caggcgatg  atccacaag  240
ccacgagcc  ggagtacgc  gtgaaggtc  tcgacgtca  cggtggagg  agcttcagc  300
cggaggagg  gcgggagct  cgagaagcc  cgctgaagg  ggtggacat  ctgcgcaag  360
tctcagggc  ccccaacat  atacagctg  aggacactt  tgagaccaa  actttcttc  420
tcttggtgt  tgacctgat  aagagaggg  agctctttg  ctacctcac  gagaaggtc  480
ccttgagtg  gaaggaaac  agaaagatc  tgcgagctc  gctggaggt  atctgcacc  540
tgcacaaac  caacatcgt  caccgggac  tgaagcccg  gaacattct  ttggatgac  600
acatgaaca  caagctcac  gactttggc  tttcctgcc  gctggagcc  ggagagagg  660
tgcgagagg  ctgcgggac  cccagttac  tggcccctg  gattatcga  tgctccatg  720
atgaggacc  cccgggcta  gggaaagag  tggacatgt  gagcactgg  gtcatcatg  780
acacgctgc  ggccggctc  ccgcccttc  ggcaccgga  gcagatgct  atgctgagg  840
tgatcatga  cggcaacta  cagtttggc  cgcccgagt  ggatgatta  tcggacacc  900
tgaaggacc  ggtctcccg  ttcctggtg  tgcaacccc  gaaccgcta  acagcggaa  960
aggccttgg  acacccctt  ttccagcag  acttggtgg  ggaagtgcg  cacttcagc  1020
cccggggga  gttcaaggt  atcgctctg  ccgtgctgg  ttcagtgcg  atctactac  1080
agtaccgcc  ggtgaagcc  gtgacccgg  agatcgtca  ccgagaccc  tatgccctc  1140
ggcctctgc  ccggctcat  gacgcctac  ctttccgaa  ctatggcca  tgggtgaag  1200
aggggcagc  gcagaaccg  gcagccctt  tcgagaaca  acccaaggc  gtgctcctc  1260
ccctggccg  ggaggacta  tgaggggct  gccagtcag  gagggctag  gggcaggtg  1320
ggaggggaa  ccatggaaa  acaagtcaa  ggggtaaaa  aaaaaaaaa  aaaaaaa  1377



<210> 9293
<211> 386
<212> PRT
<213> Homo sapiens
<308> Q16816
<400> 9293

Thr Arg Asp Glu Ala Leu Pro Asp Ser His Ser Ala Gln Asp Phe Tyr 
  1               5                  10                  15
Glu Asn Tyr Glu Pro Lys Glu Ile Leu Gly Arg Gly Val Ser Ser Val 
             20                  25                  30
Val Arg Arg Cys Ile His Lys Pro Thr Ser Gln Glu Tyr Ala Val Lys 
         35                  40                  45
Val Ile Asp Val Thr Gly Gly Gly Ser Phe Ser Pro Glu Glu Val Arg 
     50                  55                  60
Glu Leu Arg Glu Ala Thr Leu Lys Glu Val Asp Ile Leu Arg Lys Val 
 65                  70                  75                  80
Ser Gly His Pro Asn Ile Ile Gln Leu Lys Asp Thr Tyr Glu Thr Asn 
                 85                  90                  95
Thr Phe Phe Phe Leu Val Phe Asp Leu Met Lys Arg Gly Glu Leu Phe 
             100                105                110
Asp Tyr Leu Thr Glu Lys Val Thr Leu Ser Glu Lys Glu Thr Arg Lys 
         115                120                125
Ile Met Arg Ala Leu Leu Glu Val Ile Cys Thr Leu His Lys Leu Asn 
     130                135                140
Ile Val His Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp Asp Asn 
 145                150                155                160
Met Asn Ile Lys Leu Thr Asp Phe Gly Phe Ser Cys Gln Leu Glu Pro 
                 165                170                175
Gly Glu Arg Leu Arg Glu Val Cys Gly Thr Pro Ser Tyr Leu Ala Pro 
             180                185                190
Glu Ile Ile Glu Cys Ser Met Asn Glu Asp His Pro Gly Tyr Gly Lys 
         195                200                205
Glu Val Asp Met Trp Ser Thr Gly Val Ile Met Tyr Thr Leu Leu Ala 
     210                215                220
Gly Ser Pro Pro Phe Trp His Arg Lys Gln Met Leu Met Leu Arg Met 
 225                230                235                240
Ile Met Ser Gly Asn Tyr Gln Phe Gly Ser Pro Glu Trp Asp Asp Tyr 
                 245                250                255
Ser Asp Thr Val Lys Asp Leu Val Ser Arg Phe Leu Val Val Gln Pro 
             260                265                270
Gln Asn Arg Tyr Thr Ala Glu Glu Ala Leu Ala His Pro Phe Phe Gln 
         275                280                285
Gln Tyr Leu Val Glu Glu Val Arg His Phe Ser Pro Arg Gly Lys Phe 
     290                295                300
Lys Val Ile Ala Leu Thr Val Leu Ala Ser Val Arg Ile Tyr Tyr Gln 
 305                310                315                320
Tyr Arg Arg Val Lys Pro Val Thr Arg Glu Ile Val Ile Arg Asp Pro 
                 325                330                335
Tyr Ala Leu Arg Pro Leu Arg Arg Leu Ile Asp Ala Tyr Ala Phe Arg 
             340                345                350
Ile Tyr Gly His Trp Val Lys Lys Gly Gln Gln Gln Asn Arg Ala Ala 
         355                360                365
Leu Phe Glu Asn Thr Pro Lys Ala Val Leu Leu Ser Leu Ala Glu Glu 
     370                375                380
Asp Tyr 
 385



<210> 9294
<211> 1290
<212> DNA
<213> Rattus norvegicus
<308> X07636
<400> 9294

tcttagcac  aacccaatt  tagctctaa  gaaatctca  ttcagtccc  gatctgtct  60
cagcctgag  gcccatcat  gagaaggac  ttcaagata  ccagcagct  gactctgag  120
aaaacgacc  tcagctcat  ggcgatgag  aacaaggct  tcatgtgca  aatcttagg  180
cagaaaatc  acgttgggg  ggacagcct  cttccaggc  ctttccaca  cgcctctgc  240
ccaagttcc  cctcagtct  ctcgccctg  ccttcaaca  tctcctgct  gtggtcatc  300
gtgtggttt  atcccaaag  atgcagctg  aaaaggagt  ctggaccct  aaagaaacc  360
tgagcaact  ctccaccac  accctgatg  agttcaagg  tctggactc  cacggaggt  420
gcaggaatg  caacttgac  tcttgggaa  ccatactgg  gaaaaagca  aaggacata  480
aagcagatc  ctccacgct  ctcttccac  tgaagcact  ccccctgga  ctgcgaacc  540
tgacctgtc  gctggcgtt  ttcctgagc  acggcacag  atgctgccc  gttaactgg  600
tggagtttg  tggaagctg  tactggttt  ctcgggatg  gctcacctg  gctgaggct  660
accagtact  ccaaatgga  aatgcccat  tgctggtca  caactccag  gaggagcag  720
aattcgttg  aaagcacag  ggcgcgttt  acatttgga  aggtctcac  gacaaggat  780
gctcctgga  atgggtgga  gggacggaa  atagaagta  cttcaagaa  tgggctttc  840
ctcagccag  taactggca  ggccatgaa  aggggggaa  tgaagactg  gctgaaatc  900
tgtcagatg  cctctggaa  gacaacttc  gccagcagg  gaaccgctg  gcttgtgaa  960
ggaaacggg  catcaccta  taggagtct  ctctactat  tctttgtca  ccctccccc  1020
aacccccgc  tcactcatt  ggagtctgc  ctaccatgt  tctgcccca  cccatcacc  1080
catcacccc  acattttca  tggggatat  ggagcaaga  agagagaca  agtcccagg  1140
atgaggggg  ttatgggag  atggaaagg  ggtggctct  tggtctcat  cgttaggaa  1200
actgagatt  cacccctct  cacaactta  tacaattgt  ataaatttc  acaatggag  1260
aggaaagaa  aaaataaac  ataccagaaa  1290



<210> 9295
<211> 301
<212> PRT
<213> Rattus norvegicus
<308> P08290
<400> 9295

Met Glu Lys Asp Phe Gln Asp Ile Gln Gln Leu Asp Ser Glu Glu Asn 
  1               5                  10                  15
Asp His Gln Leu Ile Gly Asp Glu Glu Gln Gly Ser His Val Gln Asn 
             20                  25                  30
Leu Arg Thr Glu Asn Pro Arg Trp Gly Gly Gln Pro Pro Ser Arg Pro 
         35                  40                  45
Phe Pro Gln Arg Leu Cys Ser Lys Phe Arg Leu Ser Leu Leu Ala Leu 
     50                  55                  60
Ala Phe Asn Ile Leu Leu Leu Val Val Ile Cys Val Val Ser Ser Gln 
 65                  70                  75                  80
Ser Met Gln Leu Gln Lys Glu Phe Trp Thr Leu Lys Glu Thr Leu Ser 
                 85                  90                  95
Asn Phe Ser Thr Thr Thr Leu Met Glu Phe Lys Ala Leu Asp Ser His 
             100                105                110
Gly Gly Ser Arg Asn Asp Asn Leu Thr Ser Trp Glu Thr Ile Leu Glu 
         115                120                125
Lys Lys Gln Lys Asp Ile Lys Ala Asp His Ser Thr Leu Leu Phe His 
     130                135                140
Leu Lys His Phe Pro Leu Asp Leu Arg Thr Leu Thr Cys Gln Leu Ala 
 145                150                155                160
Phe Phe Leu Ser Asn Gly Thr Glu Cys Cys Pro Val Asn Trp Val Glu 
                 165                170                175
Phe Gly Gly Ser Cys Tyr Trp Phe Ser Arg Asp Gly Leu Thr Trp Ala 
             180                185                190
Glu Ala Asp Gln Tyr Cys Gln Met Glu Ile Ala His Leu Leu Val Ile 
         195                200                205
Asn Ser Arg Glu Glu Gln Glu Phe Val Val Lys His Arg Gly Ala Phe 
     210                215                220
His Ile Trp Ile Gly Leu Thr Asp Lys Asp Gly Ser Trp Lys Trp Val 
 225                230                235                240
Asp Gly Thr Glu Tyr Arg Ser Asn Phe Lys Asn Trp Ala Phe Thr Gln 
                 245                250                255
Pro Asp Asn Cys Gln Gly His Glu Glu Gly Gly Ser Glu Asp Cys Ala 
             260                265                270
Glu Ile Leu Ser Asp Gly Leu Trp Asn Asp Asn Phe Cys Gln Gln Val 
         275                280                285
Asn Arg Trp Ala Cys Glu Arg Lys Arg Asp Ile Thr Tyr 
     290                295                300



<210> 9296
<211> 1309
<212> DNA
<213> Homo sapiens
<308> M11025
<400> 9296

gccagggtt  cctgcggga  ccaggcgtc  gctctccac  cctttcaca  ccccagccc  60
cagagcaac  tcagcccag  ccagcccag  tccagctcc  gctccagcc  gggccccat  120
atggccaag  actttcaag  tatccagca  ctgagctcg  aggaaaatg  ccatccttt  180
catcaaggt  aggggccag  cactcgcag  ctgaatccc  ggagaggaa  tccattttt  240
aaagggcca  ctcctgccc  gcccctggc  cagcgtctc  gctccatgg  ctgcttcag  300
ctgcttgcc  tgagcttca  catcctgct  ctggtggtc  tctgtgtga  tgggtccca  360
agtgagggt  acagaggtg  acagctgca  gccgagctg  ggagcctga  ggaagcttt  420
agcaacttc  cctcgagca  cctgacgga  gtccaggca  tcagcaccc  cggaggcag  480
gtgggtgac  agatcacat  cctaggagc  aagctggag  aacagcagc  ggacctgaa  540
gcagatcac  atgccctgc  cttccatct  aagcacttc  ccgtggacc  gcgcttcgt  600
gcctgccag  tggagctcc  ccacagcaa  ggctcccaa  ggacctgct  ccccgtcaa  660
tgggtggag  accaaggca  ctgctactg  ttctctcac  ccgggaagg  ctgggctga  720
gcggagaag  actgccagc  ggagaacgc  cacctggtg  tcatcaact  ctgggagga  780
cagaaattc  ttgtacaac  cacgaaccc  ttcaatacc  ggataggtc  cacggacag  840
gatggctct  ggaaatggg  ggatggcac  gactatagg  acaactaca  gaactgggc  900
gtcactcag  cagataatt  gcacgggca  gagctgggt  gaagtgaag  ctgtgttga  960
gtccagccg  atggccgct  gaacgatga  ttctgcctg  aggtgtacc  ctgggtgtg  1020
gagaaaagg  ggaatgcca  cggcgaggt  gcctgaccc  agcacacct  tggctaacc  1080
ataccccac  cctgcccag  tctggcttc  ctgttgagg  ttttgagga  aggaagaaa  1140
actgagaca  gggtatggg  aagagctga  caaagagag  aaggaggta  tttaagagt  1200
cctgaccct  gaggactga  atcccacct  cttctgtaa  tcattgtaa  tattataat  1260
gtcagcctc  tcaatggcg  aggaaagaa  aaacaaatg  ttgaatctc  1309



<210> 9297
<211> 311
<212> PRT
<213> Homo sapiens
<308> P07307
<400> 9297

Met Ala Lys Asp Phe Gln Asp Ile Gln Gln Leu Ser Ser Glu Glu Asn 
  1               5                  10                  15
Asp His Pro Phe His Gln Gly Glu Gly Pro Gly Thr Arg Arg Leu Asn 
             20                  25                  30
Pro Arg Arg Gly Asn Pro Phe Leu Lys Gly Pro Pro Pro Ala Gln Pro 
         35                  40                  45
Leu Ala Gln Arg Leu Cys Ser Met Val Cys Phe Ser Leu Leu Ala Leu 
     50                  55                  60
Ser Phe Asn Ile Leu Leu Leu Val Val Ile Cys Val Thr Gly Ser Gln 
 65                  70                  75                  80
Ser Glu Gly His Arg Gly Ala Gln Leu Gln Ala Glu Leu Arg Ser Leu 
                 85                  90                  95
Lys Glu Ala Phe Ser Asn Phe Ser Ser Ser Thr Leu Thr Glu Val Gln 
             100                105                110
Ala Ile Ser Thr His Gly Gly Ser Val Gly Asp Lys Ile Thr Ser Leu 
         115                120                125
Gly Ala Lys Leu Glu Lys Gln Gln Gln Asp Leu Lys Ala Asp His Asp 
     130                135                140
Ala Leu Leu Phe His Leu Lys His Phe Pro Val Asp Leu Arg Phe Val 
 145                150                155                160
Ala Cys Gln Met Glu Leu Leu His Ser Asn Gly Ser Gln Arg Thr Cys 
                 165                170                175
Cys Pro Val Asn Trp Val Glu His Gln Gly Ser Cys Tyr Trp Phe Ser 
             180                185                190
His Ser Gly Lys Ala Trp Ala Glu Ala Glu Lys Tyr Cys Gln Leu Glu 
         195                200                205
Asn Ala His Leu Val Val Ile Asn Ser Trp Glu Glu Gln Lys Phe Ile 
     210                215                220
Val Gln His Thr Asn Pro Phe Asn Thr Trp Ile Gly Leu Thr Asp Ser 
 225                230                235                240
Asp Gly Ser Trp Lys Trp Val Asp Gly Thr Asp Tyr Arg His Asn Tyr 
                 245                250                255
Lys Asn Trp Ala Val Thr Gln Pro Asp Asn Trp His Gly His Glu Leu 
             260                265                270
Gly Gly Ser Glu Asp Cys Val Glu Val Gln Pro Asp Gly Arg Trp Asn 
         275                280                285
Asp Asp Phe Cys Leu Gln Val Tyr Arg Trp Val Cys Glu Lys Arg Arg 
     290                295                300
Asn Ala Thr Gly Glu Val Ala 
 305                310



<210> 9298
<211> 7776
<212> DNA
<213> Rattus norvegicus
<308> X07944
<400> 9298

ggatcccgg  atccgggct  ggaaagggg  tttagttga  aattaacaa  ccattaaca  60
cgtgtacat  gtaacaagt  ggagttact  ctaagtctt  ccaatactg  atatgtaag  120
aaccagtca  tcccactta  tctttaaca  tgtaacttt  gtgggggct  gggatttag  180
tcagtggta  agcgcttac  taggaagcg  aaggccctg  gttcggtcc  cagctccaa  240
aaaaaaaaa  accaaaaaa  aaaaaacaa  aaaacaatg  aactttggt  gatacaaat  300
cactgccca  actcttttc  ggtccagac  tctcaaagt  acttagttg  agctaccct  360
aaagattta  cagaataag  gacagctgt  ggcttgaaa  ccctcaacc  cttccctaa  420
atgcgactc  tgcttagat  aaaggcatt  tcttagcat  caactggtg  ctagaatct  480
gttggaagc  accaacgta  aacggagtg  ctctccagc  tctgctggc  tgtctctca  540
caagttttc  ggcataggc  cacagggtg  tgaagcagg  tcaatctac  ccacgaagt  600
tagtctacg  ggcccgcac  caactcaag  cccatccat  ctcggctcg  acctgcgat  660
ccgccaggg  ataaatact  cgcgctgaa  gcaaagccg  ggaagagtt  tgctagtct  720
ccaggccag  gctcagccg  taggacccg  ggagagact  cgtgattga  ccggttgca  780
gacggacga  caagcgcct  tgcgcatgc  ccggccgaa  cccgcctgc  gcccatagg  840
ccctgcggc  agctggtag  caggactgg  ggtgtggtg  gcgtgcgcg  gcctgccgc  900
gggagtgtc  ggcacgagg  cgggcgggg  gcgcgggcg  atgggcggg  ggctgggca  960
gcgcggcgc  ccgccccac  gacgcgccg  gcccgcgcc  cccgcctcc  gcgtcggga  1020
ccgggttgg  cgccaagga  tccccgccc  tcccccgcg  ctcccggcc  gaaccgatc  1080
gggctggtt  gagctggtg  gtctccatg  cgacgtgct  cgcctataa  tagcggcgc  1140
tcgcaccgt  gggctttgt  agtccctgc  gccgccgcc  ccggccgcc  tcagtcagc  1200
gctcggcgc  acctccggt  ggcgactgc  gcgggctcg  cgaggcggc  gacggggcg  1260
cggcgggaa  acggccggg  gcgccttgg  gtttagtgg  ggcttctcc  tgggtccag  1320
cagccgctt  cctgtgctg  gaggtaagc  gggcgcggg  ggattgtgc  gccacgtgt  1380
gcgaggccc  gactgcggt  gccggcagg  gacacgtgg  cggaggctg  tgaccttgc  1440
agcctccgc  ctgaaggca  cagctgttc  tggcccttg  ctgcaagcc  tcggatcgc  1500
ccatgggag  ccgcatcgt  tcagccggg  tcggcgctc  acttgcccg  gcggtgatg  1560
agggcaggt  caggggagc  cggccgcta  cagccgccc  gcagtttcc  gctttcttt  1620
gttttgcta  gtgtacaga  cagagctga  gactcgaag  ggaagtcga  agacctaat  1680
tagtcaggg  gtccctgct  atgaatact  accggctgt  acttggatt  agaactgaa  1740
tctttgaat  acttagggg  ttacgggaa  cggattccc  gctgtcttg  aagcccgac  1800
cagaatcct  aataactgg  agaactggg  agcagatcc  gtcaggaat  tctgggaga  1860
gacaaaaga  tgcagtggc  tgttttatt  aaacctaac  tcgggcaga  tttgactgg  1920
gttcatttt  gttttaatt  gcttgtatc  catccagat  taacttctt  tgctaattg  1980
ttaacagga  ttagctgct  cccatgcca  agtgttagc  ttttttttc  tttatcttt  2040
ttttctttt  ctttttttt  ttttttttt  ttgtattga  gcaaagata  ggaaaggca  2100
aataagtgg  atttcaatg  aagttttcc  ggtttaagc  ggaaggctg  ctggaaaat  2160
cttaacaag  cctaaaatt  caaagttac  gccaaagcc  attcatcag  tctaagtga  2220
atacaactg  gttggctgg  gctggtctg  agtcttcac  taagagagg  ttatgcagc  2280
aacgaagtt  accagtgcc  aaagtctcc  taaagctta  agtgtgctt  atcatgcat  2340
gatttggat  tatgacagg  tcatccccg  ggcctctca  agtgtcccg  gctagagca  2400
actggctcc  aaccattgc  cagccttgg  gcatgtagg  tgctggcac  gaagtgggt  2460
acacaatgg  aaaaagttt  acctggcca  ttgctgctg  tgtccattt  ataagaccc  2520
ggcaggagc  tttattaag  gtggtgatc  tgcttattt  tgttagtaa  aaagttggc  2580
aaaaatttc  tccatatgg  tattatcca  aagtggata  tagaaggca  ttgaggact  2640
ttggattcc  agaagtgcg  atttggtag  caatccagg  tctagaata  tgatgtttc  2700
taacagtaa  aatatactg  gaattgaat  tttttaaat  ctagtactg  ataaaagtt  2760
gggaagttt  ggtggattg  acactaaca  tgagtgctc  ggatacctg  tatactgta  2820
tcactaagt  attcagcat  actctgcaa  tgggagaaa  agacctttt  aggactgca  2880
gttactgta  gcccattaa  gtttttgaa  agctggaat  gctcaaatg  agcagatag  2940
aacatgtaa  aatgccagt  attagactg  taactccgt  ccgttttgg  gaggggcag  3000
gattgagat  ttctatgtg  atagagctg  ggcattcag  tttgaacag  gtggaatct  3060
tttgagtat  ggagatatt  ggggggggg  tcttcacgt  gttctgacc  cacagttga  3120
cttcctgta  tgtgtactc  ctggtatac  gttgcagtg  gtaaccttt  atggtaaga  3180
ttcaaggga  atagcaaca  gttgtgttt  tactcacta  tgtttccac  actccagga  3240
acagcattc  gagttgacc  tgtgagagc  ggccataat  taattccat  tctaggttt  3300
ctgtgtaag  atcagttta  acttgtgaa  ttgtgttga  gcagtgcta  gactttgag  3360
gcattcact  attatctgc  tattgtcag  ttattgttt  agaggcaca  cgagaacca  3420
ccatgggca  ctttactaa  gaagagttt  actgccata  cctcgatga  ggtttcact  3480
ctaaggaca  tctggacca  aaaatcaat  aagtttctt  ctctgtaag  acgggaagc  3540
cacagccac  actcaaaag  tccataaaa  agcatgcct  gccagagaa  ctagaattt  3600
actgactgg  ctgtctagt  agtgtccat  tcagtactg  taacaggga  aggattttg  3660
tagggaagg  ggaaaaaga  cttcagtgt  gccaggtgc  agactgtta  tgaggtccc  3720
gaacccact  actctcatt  caggatgat  aggatgctt  ctatgttgc  gacctcgga  3780
acgttctaa  gaagcatct  aggtggctg  aagctcttc  ccgtgttac  cccttctat  3840
ctgtcaagt  taatgacag  agagccata  tgagcaccc  ggctgccat  gggacagga  3900
ttgattgtg  aagcaaggt  agactgctt  tctcacccc  aaagggtta  cagttgatg  3960
gcttttgtt  gtcaaactc  gtctatata  actgatctt  tctttcaga  tgaaataca  4020
ttggtgcag  ggcttgggg  gcctccaga  aggattatc  atgcaaatc  ttgtaagca  4080
gtgtctcag  tcaagtatg  tgccagtaa  ggagtccag  tgatgactt  tgacagtga  4140
attgagttg  tgaaagttg  cagagcaca  ccaaaggca  agtaagtct  ctgattgag  4200
acaaaaagg  tgggcttgc  aggcagact  taatcttgg  tccttattc  tatacatag  4260
aagaaccag  ctaaaccct  ggttagaat  agacccaca  gcagtagtg  ctagacagg  4320
tgattggat  aacgtgtac  gagtgctta  ttggtgcat  cacttgttt  tgtccacct  4380
ggttggttt  gcggattgc  actgatgat  ccaaagcag  ttgtcggct  agtgttaag  4440
ttggtgcca  actgaaaac  agcaggctt  tcttggaac  ggcaaaaga  ctaaatatt  4500
atgtcattg  tgtcaggtg  ggtctcagt  atagttaca  actgagaca  taaatttta  4560
ggccctttt  tcctctgag  actagtcaa  gaacagcat  ttgttttta  ttcagcttc  4620
atgtgggca  tgggtgtac  gaccctgag  ccttcgtgc  ggcagtgtc  gatgcccgc  4680
gtgtctttg  catgggagt  agtacatga  tcctggagg  gggctgtct  gattgaaat  4740
accaaacca  tgaatctag  atttgcctc  tgtagaagc  gtctgcata  cagatttta  4800
aaccatctg  cctgtgcat  taaacttgt  aatctagca  tttgacttc  aaattttct  4860
gattctaga  agaagttgg  ttcagcatg  atctgcttg  cattggtgg  ggctttcct  4920
ggtctgaag  cacgaagct  aaatttgag  aggtaatta  tacaacatt  acctacaga  4980
ggtgagata  gtatttacc  ttgtggtgt  tttactgat  aaaggagcc  acatgcctg  5040
tgttttgtt  tcactactt  ttatttgca  ctgtagccc  ggctggcct  gaactttca  5100
ttctcctgc  tgtttccca  attttaatg  ttagctcag  gcttatcac  attgtacta  5160
gaagtagac  gggtggaag  agttatatc  tgttggcat  tattcagaa  tcagcattt  5220
gcccctctt  taatccatt  tgtgctatt  tattaaata  taatataaa  tattcataa  5280
gtgttagaa  gagatggtc  tgaggggag  gggaagtgg  gtatgtaca  actagtttc  5340
agagaggtt  gttgcttct  ttgcctgat  acagacctg  tatgctagg  catgtcctg  5400
tcttacaca  agcagtgtg  tctttctcc  caactataa  aaatggctg  tcccttctc  5460
cacttagat  accagtgta  tcaacccag  tctggacaa  tacttccca  cggactctg  5520
agtgagaat  atagctgag  caggcagat  ctacgtcgc  tcagctttc  cacttgcag  5580
gaatatcat  gccaaaaaa  ccgtgtgga  ggagcagac  ggctcggac  gtatgtggt  5640
gcaggatga  tgagtcatg  gggataaca  ttgatatgc  gggtggtaa  tagggtgat  5700
tgtttttct  gatgaagat  agtcaaacg  gcaaacttt  atgtattac  tgaatgatg  5760
agtgtatgg  tcatttaac  gcattcttt  tgaccatgc  catgtgaag  ccctgctgc  5820
gaaggtgag  tctgagcgc  tgctctagc  gtgagtgat  cataggata  agagaacat  5880
gggccgaga  atggctcag  agttaagag  actgactgc  tccagaggc  ctgagttca  5940
tcccagcaa  aacatggtg  ctcaccacc  tctgtatgt  atgatgccc  cttctggtg  6000
gtctgaaga  tagctacag  gtatttata  tctttaaaa  aaaacaaac  aaaaacaaa  6060
attgtcttt  tacagagac  caagccaga  gagaagtat  actcatcca  catctgggg  6120
ccaacatgt  atggccttg  tcggatcgt  gagcgctgt  gcctgcctg  aatgcatgt  6180
ggtgattgg  tgctgtttg  gaacatggg  gcatacact  ttgctgctg  ttctacttt  6240
aatgggttc  agaggccaa  catctacta  gtaatgtca  ggtcaatgt  gtgagtggg  6300
ctgtgcctg  tcatgctct  ttggttgct  agtgtaatg  ttgcctact  tgagccaga  6360
gcctgggtt  tgcctgatg  acacacaca  acatactat  gggggaagg  agtatgtgc  6420
gaggggaag  atcacctga  ctgtctcaa  gggactgaa  ttgtgcttg  tttttatgt  6480
tgataagtt  tttttttac  ttgagctaa  tacagaaat  gagtttttc  aagtaatta  6540
tgctcatct  cagatattt  ctactagga  aggtcttac  agtaagcca  tagattctt  6600
tgcaactaa  atattcaag  tagcatatg  gacctgtgg  ttccttaat  atgaaattt  6660
acattggat  gtttcctgg  atagtgaca  ggtgaggtg  caggagatc  cttgggagg  6720
tgcccaatt  ggagggatt  gggttttga  tatgccata  atgcctttg  ttttcaggc  6780
actcatgaa  caaatccag  gccatggct  cccgccaga  gtggaggag  aggatgttg  6840
cactctgcc  atgtcttgt  cccaggaga  cgggatgga  cgtcaccct  cagcctgtg  6900
ttctgctag  atcaatgta  agatgccat  cttgtagct  ttacctgca  gtttagctt  6960
agttcacgg  atttggggg  accatttaa  ttaattact  ctagtttgg  atgtctttg  7020
aagagtagg  ttggcacca  tgcagtatg  aaagactag  agatggggg  cacacttac  7080
gtgttccta  ggaaacttt  aatatttta  atggatttt  attcacttt  cagacctga  7140
actaatgag  gcccctcgg  tgctgagca  gcatttgta  cttgtacat  ggcagaatg  7200
gctaaaagc  tatgttgtg  cccattttg  aaataaagt  tcttgaaat  attggacat  7260
ggagaatgt  tgcaagtat  ccttacaga  ggcacaaac  tctgcacag  ctgtgtgtt  7320
cagcagtga  tctagccca  cagagatgt  gatgataca  agctgtgcc  cctctgtac  7380
gcatcaatg  gcttagccc  tctcaagtg  ttactgtga  cttggtgcc  aaagtctct  7440
aagagtgtc  tctgcctag  ggcctcttg  cttggccac  tcctaagga  agggcatct  7500
aggctcttt  aaccttgcc  gcagaaacc  tgactgctc  ctcaaccct  ggcctcagc  7560
gcatcacca  ctagtaaca  ttgaagtat  gaacagcac  tggcagtca  cttcctgta  7620
taaattcaa  aacagcaac  actgtgttg  aaattttta  cttgacctt  catattata  7680
tcctgctca  tttatacac  tattgcatc  ccaaagaaa  gccagactc  taacctagt  7740
agtattgaa  acctgtagg  caggaggaa  ggatcc  7776



<210> 9299
<211> 461
<212> PRT
<213> Rattus norvegicus
<308> CAA30765
<400> 9299

Met Gly Ser Phe Thr Lys Glu Glu Phe Asp Cys His Ile Leu Asp Glu 
  1               5                  10                  15
Gly Phe Thr Ala Lys Asp Ile Leu Asp Gln Lys Ile Asn Glu Val Ser 
             20                  25                  30
Ser Ser Asp Asp Lys Asp Ala Phe Tyr Val Ala Asp Leu Gly Asp Val 
         35                  40                  45
Leu Lys Lys His Leu Arg Trp Leu Lys Ala Leu Pro Arg Val Thr Pro 
     50                  55                  60
Phe Tyr Ala Val Lys Cys Asn Asp Ser Arg Ala Ile Val Ser Thr Leu 
 65                  70                  75                  80
Ala Ala Ile Gly Thr Gly Phe Asp Cys Ala Ser Lys Thr Glu Ile Gln 
                 85                  90                  95
Leu Val Gln Gly Leu Gly Val Pro Pro Glu Arg Ile Ile Tyr Ala Asn 
             100                105                110
Pro Cys Lys Gln Val Ser Gln Ile Lys Tyr Ala Ala Ser Asn Gly Val 
         115                120                125
Gln Met Met Thr Phe Asp Ser Glu Ile Glu Leu Met Lys Val Ala Arg 
     130                135                140
Ala His Pro Lys Ala Lys Leu Val Leu Arg Ile Ala Thr Asp Asp Ser 
 145                150                155                160
Lys Ala Val Cys Arg Leu Ser Val Lys Phe Gly Ala Thr Leu Lys Thr 
                 165                170                175
Ser Arg Leu Leu Leu Glu Arg Ala Lys Glu Leu Asn Ile Asp Val Ile 
             180                185                190
Gly Val Ser Phe His Val Gly Ser Gly Cys Thr Asp Pro Glu Thr Phe 
         195                200                205
Val Gln Ala Val Ser Asp Ala Arg Cys Val Phe Asp Met Gly Thr Glu 
     210                215                220
Val Gly Phe Ser Met Tyr Leu Leu Asp Ile Gly Gly Gly Phe Pro Gly 
 225                230                235                240
Ser Glu Asp Thr Lys Leu Lys Phe Glu Glu Ile Thr Ser Val Ile Asn 
                 245                250                255
Pro Ala Leu Asp Lys Tyr Phe Pro Ser Asp Ser Gly Val Arg Ile Ile 
             260                265                270
Ala Glu Pro Gly Arg Tyr Tyr Val Ala Ser Ala Phe Thr Leu Ala Val 
         275                280                285
Asn Ile Ile Ala Lys Lys Thr Val Trp Lys Glu Gln Thr Gly Ser Asp 
     290                295                300
Asp Glu Asp Glu Ser Asn Glu Gln Thr Leu Met Tyr Tyr Val Asn Asp 
 305                310                315                320
Gly Val Tyr Gly Ser Phe Asn Cys Ile Leu Tyr Asp His Ala His Val 
                 325                330                335
Lys Ala Leu Leu Gln Lys Arg Pro Lys Pro Asp Glu Lys Tyr Tyr Ser 
             340                345                350
Ser Ser Ile Trp Gly Pro Thr Cys Asp Gly Leu Asp Arg Ile Val Glu 
         355                360                365
Arg Cys Ser Leu Pro Glu Met His Val Gly Asp Trp Met Leu Phe Glu 
     370                375                380
Asn Met Gly Ala Tyr Thr Val Ala Ala Ala Ser Thr Phe Asn Gly Phe 
 385                390                395                400
Gln Arg Pro Asn Ile Tyr Tyr Val Met Ser Arg Ser Met Trp Gln Leu 
                 405                410                415
Met Lys Gln Ile Gln Ser His Gly Phe Pro Pro Glu Val Glu Glu Gln 
             420                425                430
Asp Val Gly Thr Leu Pro Met Ser Cys Ala Gln Glu Ser Gly Met Asp 
         435                440                445
Arg His Pro Ala Ala Cys Ala Ser Ala Ser Ile Asn Val 
     450                455                460



<210> 9300
<211> 2062
<212> DNA
<213> Homo sapiens
<308> NM_002539
<400> 9300

gtcagtccc  cctgtagcc  ccgccgccg  cgcccgccg  ccctctgcc  gcagctccg  60
cgccacctc  ggccggcgt  tccggcggg  gggagccag  cgctgacgg  cgcggcggg  120
gcggccgag  gctcctgcg  ctgcgactc  ggctccggc  tctgcgctt  cccatgggg  180
tggcctgcg  cgcctgggc  ctctgagat  gtcactgct  ttccaaggg  acacgcaga  240
ggatttgga  ttcctggag  gttgccttt  tgagaagct  gaaatattt  tttcaattc  300
atctcttag  tttccatag  aacatcaag  aatcatgaa  aactttggt  atgaagagt  360
tgactgcca  ttcctcgat  aaggtttta  tgccaagga  attctggac  agaaaatta  420
tgaagtttc  tcttctgat  ataaggatg  cttctatgt  gcagacctg  gagacattc  480
aaagaaaca  ctgaggtgg  taaaagctc  ccctcgtgt  acccccttt  atgcagtca  540
atgtaatga  agcaaagcc  tcgtgaaga  ccttgctgc  accgggaca  gatttgact  600
tgctagcaa  actgaaata  agttggtgc  gagtctggg  gtgcctcca  agaggatta  660
ctatgcaaa  ccttgtaaa  aagtatctc  aattaagta  gctgctaat  atggagtcc  720
gatgatgac  tttgatagt  aagttgagt  gatgaaagt  gccagagca  atcccaaag  780
aaagttggt  ttgcggatt  ccactgatg  ttccaaagc  gtctgtcgt  tcagtgtga  840
attcggtgc  acgctcaga  ccagcaggc  ccttttgga  cgggcgaaa  agctaaata  900
cgatgttgt  ggtgtcagc  tccatgtag  aagcggctg  accgatcct  agaccttcg  960
gcaggcaat  tctgatgcc  gctgtgttt  tgacatggg  gctgaggtt  gtttcagca  1020
gtatctgct  gatattggc  gtggctttc  tggatctga  gatgtgaaa  ttaaatttg  1080
agagatcac  ggcgtaatc  acccagcgt  ggacaaata  tttccgtca  actctggag  1140
gagaatcat  gctgagccc  gcagatact  tgttgcatc  gctttcacg  ttgcagtta  1200
tatcattgc  aagaaaatt  tattaaagg  acagacggg  tctgatgac  aagatgagt  1260
gagtgagca  acctttatg  attatgtga  tgatggcgt  tatggatca  ttaattgca  1320
actctatga  cacgcacat  taaagcccc  tctgcaaaa  agacctaaa  cagatgaga  1380
gtattattc  tccagcata  ggggaccaa  atgtgatgg  ctcgatcgg  ttgttgagc  1440
ctgtgacct  cctgaaatg  atgtgggtg  ttggatgct  tttgaaaac  tgggcgctt  1500
cactgttgc  gctgcctct  cgttcaatg  cttccagag  ccgacgatc  actatgtga  1560
gtcagggcc  gcgtggcaa  tcatgcagc  attccagaa  cccgacttc  cacccgaag  1620
agaggaaca  gatgccagc  ccctgcctg  gtcttgtgc  tgggagagt  ggatgaaac  1680
ccacagagc  gcctgtgct  cggctagta  taatgtgta  atagcactc  ggtagctgt  1740
aactgcaag  ttagcttga  ttaagggat  tggggggac  atgtaactt  attactgct  1800
gttttgaaa  gtctttgta  gagtagggt  gccatgatg  agccatatg  aagactagg  1860
tatgggtca  acttatctg  gttcctatg  aaactattt  aatatttgt  ttatatgga  1920
ttttattca  tcttcagac  cgctactca  gagtgcccc  cagctgctg  acaagcatt  1980
gtagcttgt  caatggcag  atgggccaa  agcttagtg  tgtgacctg  ttttaaaat  2040
aagtatctt  aaataatta  gc  2062



<210> 9301
<211> 461
<212> PRT
<213> Homo sapiens
<308> P11926
<400> 9301

Met Asn Asn Phe Gly Asn Glu Glu Phe Asp Cys His Phe Leu Asp Glu 
  1               5                  10                  15
Gly Phe Thr Ala Lys Asp Ile Leu Asp Gln Lys Ile Asn Glu Val Ser 
             20                  25                  30
Ser Ser Asp Asp Lys Asp Ala Phe Tyr Val Ala Asp Leu Gly Asp Ile 
         35                  40                  45
Leu Lys Lys His Leu Arg Trp Leu Lys Ala Leu Pro Arg Val Thr Pro 
     50                  55                  60
Phe Tyr Ala Val Lys Cys Asn Asp Ser Lys Ala Ile Val Lys Thr Leu 
 65                  70                  75                  80
Ala Ala Thr Gly Thr Gly Phe Asp Cys Ala Ser Lys Thr Glu Ile Gln 
                 85                  90                  95
Leu Val Gln Ser Leu Gly Val Pro Pro Glu Arg Ile Ile Tyr Ala Asn 
             100                105                110
Pro Cys Lys Gln Val Ser Gln Ile Lys Tyr Ala Ala Asn Asn Gly Val 
         115                120                125
Gln Met Met Thr Phe Asp Ser Glu Val Glu Leu Met Lys Val Ala Arg 
     130                135                140
Ala His Pro Lys Ala Lys Leu Val Leu Arg Ile Ala Thr Asp Asp Ser 
 145                150                155                160
Lys Ala Val Cys Arg Leu Ser Val Lys Phe Gly Ala Thr Leu Arg Thr 
                 165                170                175
Ser Arg Leu Leu Leu Glu Arg Ala Lys Glu Leu Asn Ile Asp Val Val 
             180                185                190
Gly Val Ser Phe His Val Gly Ser Gly Cys Thr Asp Pro Glu Thr Phe 
         195                200                205
Val Gln Ala Ile Ser Asp Ala Arg Cys Val Phe Asp Met Gly Ala Glu 
     210                215                220
Val Gly Phe Ser Met Tyr Leu Leu Asp Ile Gly Gly Gly Phe Pro Gly 
 225                230                235                240
Ser Glu Asp Val Lys Leu Lys Phe Glu Glu Ile Thr Gly Val Ile Asn 
                 245                250                255
Pro Ala Leu Asp Lys Tyr Phe Pro Ser Asp Ser Gly Val Arg Ile Ile 
             260                265                270
Ala Glu Pro Gly Arg Tyr Tyr Val Ala Ser Ala Phe Thr Leu Ala Val 
         275                280                285
Asn Ile Ile Ala Lys Lys Ile Val Leu Lys Glu Gln Thr Gly Ser Asp 
     290                295                300
Asp Glu Asp Glu Ser Ser Glu Gln Thr Phe Met Tyr Tyr Val Asn Asp 
 305                310                315                320
Gly Val Tyr Gly Ser Phe Asn Cys Ile Leu Tyr Asp His Ala His Val 
                 325                330                335
Lys Pro Leu Leu Gln Lys Arg Pro Lys Pro Asp Glu Lys Tyr Tyr Ser 
             340                345                350
Ser Ser Ile Trp Gly Pro Thr Cys Asp Gly Leu Asp Arg Ile Val Glu 
         355                360                365
Arg Cys Asp Leu Pro Glu Met His Val Gly Asp Trp Met Leu Phe Glu 
     370                375                380
Asn Met Gly Ala Tyr Thr Val Ala Ala Ala Ser Thr Phe Asn Gly Phe 
 385                390                395                400
Gln Arg Pro Thr Ile Tyr Tyr Val Met Ser Gly Pro Ala Trp Gln Leu 
                 405                410                415
Met Gln Gln Phe Gln Asn Pro Asp Phe Pro Pro Glu Val Glu Glu Gln 
             420                425                430
Asp Ala Ser Thr Leu Pro Val Ser Cys Ala Trp Glu Ser Gly Met Lys 
         435                440                445
Arg His Arg Ala Ala Cys Ala Ser Ala Ser Ile Asn Val 
     450                455                460



<210> 9302
<211> 4964
<212> DNA
<213> Rattus norvegicus
<308> X08056
<400> 9302

gaattctga  ctctgctct  cacacattc  ctgcccctc  gcacaacac  catgtacat  60
taaaaaaaa  taagaaaca  accaaaggg  ttggggatt  agctcagtg  tagagcgct  120
gcctaggaa  cgcaaggcc  tgggtttgg  ccccagctc  gaaaaaaag  accaaaaaa  180
aaaaaaaag  gagagaaac  aaccaaaaa  cccaaaaca  aagtgttaa  tgtttcaat  240
ctaaactgg  ggccctggt  tccactcct  gtttttagc  gttttccct  cctgtaaaa  300
gagagtact  acagttact  ctgtagcat  ttctatggg  taagagttt  actgttctt  360
tagcagttc  cagaaaaat  atcatcttc  aaaggttaa  agtttcact  ttcttctag  420
agttctcag  aaaatgatc  gatcactac  cctaacctg  ccaagtgac  caggagcta  480
agcgggtga  tgacaggtg  ggattggac  agctgggaa  gaccggctt  ttggacctc  540
ccaggccaa  gagtgtcta  acttgaggc  tccagccag  catggcggc  cacgccttt  600
atcccagca  ttcagaggt  gaatcagac  gaactcaga  aaagggcca  cttggccta  660
acagcaagc  ccaggccag  caggagctc  tgtctctaa  taaacagat  aaagagaaa  720
aaaaaaaat  aactttttg  tttgaggag  atcgtggag  gcagctagg  tcagcaagt  780
tcacagcct  ttcagacag  aagtagagt  cccttgtca  ccagccaag  aaatgcaga  840
agtcaagct  cattccaaa  gtctggtac  agggagctt  ccccgcacc  cgcagaagc  900
acaacagta  ttctttcgg  ggcactggt  ccactggta  tctctaagc  tccctccct  960
caccgcacg  acttcgccc  tcaaggcta  aacttcctg  ctagataac  aggctccgc  1020
caggcccgt  ggctccgcc  cactcataa  aaaagactg  attcagctc  acccacgaa  1080
aactacccc  gccctaggc  ggcctccta  gcgccaacc  caccctagc  gaaagctag  1140
ccggggctc  agttttgcc  ctaccaggc  aggccccac  cgtgggaga  gactaggct  1200
cgccactag  agaaggctt  gatttcatc  tatcccata  acacctacc  catggctct  1260
tcctcatcc  tagcagaaa  ctggaccat  caccgtccc  gccggctgg  cccgttcct  1320
agcttcttc  ctcatactt  gcagaaaga  gaccccacc  cattgctcc  gtcccgccc  1380
tagcagaag  ctggactct  ccctaccct  caggctcca  cctgtatgg  tcctgcctg  1440
atccctcat  caagtctgg  ttctgtcca  cccacaggt  tggccccat  catagcaaa  1500
aggttggac  cctccccag  ccaccacta  gtatgcgac  ctagagatc  ggtaccgag  1560
tcggtaccc  gggttcctc  acacccccc  tgcaggacc  atcccattc  atagatccg  1620
ccctcacag  actttactc  gggttccag  cagtagccc  taccctgag  acgctccac  1680
ctgccctca  actccatcc  cccaggccc  ggcccagta  taggctggc  accctcccg  1740
atcaaggcc  aaccctttt  taatgactg  accctccct  tcccagcaa  gcccgcccc  1800
gctaatagg  cccgccacc  ggcccagca  tggactccc  cggggcaca  aggtcccgc  1860
cccgcctca  gctcccacc  accccagtg  aaggctaaa  tcctctttg  agaggcgcc  1920
ccccacccc  cctcctcca  cctggtggt  ccgcagccg  actctcctg  cctggtgtg  1980
acagcctca  catgagttc  tctgcagcc  gcccgcttt  cgcgcctgg  gaggactgc  2040
gccccgcgt  gcgcgcggc  cccgcggcc  atgatacgt  tgacacgca  ctgcagatc  2100
tgggcaagc  agtaatgga  cgttgggag  ccccctaca  gcattcgct  gcggctgct  2160
ctgcctcca  aggtactct  cccagaaga  acggaggct  ctgtttaag  agtgtagga  2220
ttcccatgc  tgctgcatg  ctgagtttc  ttacctgag  cactgagct  ccttggggt  2280
accttggca  ggaagggaa  agtgttggc  aaatgtaga  gcaggcaag  gaagccggc  2340
ccgaactag  acttcctct  ctggggaaa  agacttcta  ttcccggag  tgggttgga  2400
ggtggatct  cggaccaca  cctcgagtg  agcttagag  acatggagg  gcgtgggac  2460
tgtgcgggt  gggaacctc  gagtttccc  aggctgttg  taagaatag  ttgggaaaa  2520
ggagcagag  ggcagctgt  cggtgctat  gccctgaac  tctggacga  gggtggtgt  2580
tgggacacc  cagcctcaa  caggtcaat  gccaaaggg  ttcaaagtt  acccggagc  2640
catgaggac  tggtatcaa  tgcggaatg  aacatggag  ggttacagt  tcgggcctc  2700
gaaccaggc  tggcccttt  taaccccac  tagggccat  gcacaaata  cgtgggtgg  2760
catgggctc  gagtccagg  atccctggg  ccaagccca  aagcacgtg  ccagtccct  2820
aggctccca  gctcgccgc  ctgattggc  gctggccag  gcccacact  tctgtgcta  2880
tttgttctg  ccacccact  ctggctggc  gtccttgag  catgtgtga  accggtcca  2940
cctaaccgt  cccctcccc  acccatgcc  gctgtagtg  ttttgtcct  ctagggggc  3000
gggtcctgg  agtgggctt  gggatggcc  ttgcagcct  cagggtgca  caggccccc  3060
taaaggaac  ctggattat  gaatgcaac  atggggtct  ccagcgtct  caaaactgg  3120
ccctgaagc  gccacataa  gtaccttct  tcactggag  aggaggctg  gagtacccc  3180
ccgggacta  ggagatcat  gggggtacc  atgtgaccc  ttatatcct  ctcttgctc  3240
cttctcctc  ccaaggttg  tcccttgaa  ggcctgtgg  aggaggagg  acctacact  3300
cctgatggt  actttgatg  gagggcact  tgggagcct  gcaaggggg  tggcctctg  3360
gtactgatt  gcagcctct  gggctatca  accctcctt  gctcagtgg  gcttgccgt  3420
aagaatgag  accagagtt  gatccccag  atgcatgtg  tgtaaggag  gaatgggtg  3480
tcataagtt  tcccctacc  caacaaatg  acctccaat  tgcactggg  acatagcct  3540
cgggaaaag  ctccatgaa  tggctagca  aggtgctaa  ggcagctgg  cgggctggg  3600
agtttggcc  ccaaggcca  gggataggt  ggatgaagc  tgggcaagg  tgtgccagc  3660
ctgactggc  ggcctgtgt  cacgctgca  gggattcta  acgacacat  tccactgtc  3720
gaagagacc  ggcacactc  ccagttcaa  tttattaag  tgggactgc  gggccgggg  3780
ccgagggcc  tggacggtc  ggtgggcag  gtgtgatat  tacagacca  cagctctct  3840
ctcatggtc  ctccacccc  tcttgtcca  gccctttct  tctctctgc  gactcatgc  3900
ttccgtttg  tgaagcctg  gggtatcct  acttactgc  acctcacgt  ctgggggga  3960
ctcatgaag  ccaagtaca  agacatcac  gccatgttt  aggtacgct  cctcatagc  4020
agtgggggc  ccgacccaa  agccaggca  tggcccggc  agtgtggtg  tgagaccca  4080
gacatgggg  agaggtcca  tcagggctt  tctgcagcc  gaacctact  ctctctgcc  4140
gtggggcgg  gcctgagag  tgcccacca  ggccatcag  acagcttcc  ttcagcgca  4200
gaggcagct  ttggcacag  aaactcctc  tgctcgaga  gcctacagc  ggcctgtgc  4260
aggatgctg  tctgagaca  agctgaggt  atcaggaaa  ctcgttgcc  gcatagaat  4320
cacactcac  ctaggccct  tcccgcatc  tcagtggtg  cctgtgacc  ctccctaca  4380
gagactcag  tgcctgcac  gctggaagc  ggcttccag  gagaaaaca  ctgtacaga  4440
gtgatggcg  tggtgcccc  agccgactg  cgctactat  ccttccctc  gatgatcac  4500
cccctggtc  ccaagcact  agcggctgg  ccagggcta  aaggagaat  tgtcctcct  4560
agtgccttt  tagctggag  gtgggctcc  gcctctcca  tatccctgc  gtgtgacat  4620
ctaacctct  cctggtacg  ccatctccc  agagctcag  agtaaaata  atgctacca  4680
gactagtag  gggttggct  gcggtgagc  ggaggtgag  cccgcatct  gttcagagc  4740
tgcctctcc  tgcctccat  gatgtggct  ttccatcac  ggtgctcag  ggcccccga  4800
ccagacatg  ccaatcaac  attgtatgt  ttcaacagt  gcccaggaa  agcctgggg  4860
ctcaccagg  tcagggtag  gagagcctc  acgggtccc  gcccagcac  cagcaagtc  4920
tgcaaccct  atggcacga  cctactctg  acatctctg  tacc  4964



<210> 9303
<211> 235
<212> PRT
<213> Rattus norvegicus
<308> CAA30845
<400> 9303

Ser Ser Ser Ala Ala Ser Pro Leu Phe Ala Pro Gly Glu Asp Cys Gly 
  1               5                  10                  15
Pro Ala Trp Arg Ala Ala Pro Ala Ala Tyr Asp Thr Ser Asp Thr His 
             20                  25                  30
Leu Gln Ile Leu Gly Lys Pro Val Met Glu Arg Trp Glu Thr Pro Tyr 
         35                  40                  45
Met His Ser Leu Ala Ala Ala Ala Ala Ser Arg Gly Gly Arg Val Leu 
     50                  55                  60
Glu Val Gly Phe Gly Met Ala Ile Ala Ala Ser Arg Val Gln Gln Ala 
 65                  70                  75                  80
Pro Ile Lys Glu His Trp Ile Ile Glu Cys Asn Asp Gly Val Phe Gln 
                 85                  90                  95
Arg Leu Gln Asn Trp Ala Leu Lys Gln Pro His Lys Val Val Pro Leu 
             100                105                110
Lys Gly Leu Trp Glu Glu Glu Ala Pro Thr Leu Pro Asp Gly His Phe 
         115                120                125
Asp Gly Ile Leu Tyr Asp Thr Tyr Pro Leu Ser Glu Glu Thr Trp His 
     130                135                140
Thr His Gln Phe Asn Phe Ile Lys Thr His Ala Phe Arg Leu Leu Lys 
 145                150                155                160
Pro Gly Gly Ile Leu Thr Tyr Cys Asn Leu Thr Ser Trp Gly Glu Leu 
                 165                170                175
Met Lys Ser Lys Tyr Thr Asp Ile Thr Ala Met Phe Glu Glu Thr Gln 
             180                185                190
Val Pro Ala Leu Leu Glu Ala Gly Phe Gln Arg Glu Asn Ile Cys Thr 
         195                200                205
Glu Val Met Ala Leu Val Pro Pro Ala Asp Cys Arg Tyr Tyr Ala Phe 
     210                215                220
Pro Gln Met Ile Thr Pro Leu Val Thr Lys His 
 225                230                235



<210> 9304
<211> 1086
<212> DNA
<213> Homo sapiens
<308> NM_000156
<400> 9304

ccccggccc  caagcccct  cagggagcg  gcccgggcg  cgcgcgatc  aggtcgggt  60
gccgtccag  ctgcagcat  agcgccccc  gcgcgaccc  catcttcgc  cccggcgag  120
actgcagcc  cgcgtgggg  gcggcgccc  cggcctacg  cgcagcgga  acgcacctg  180
gcatcctgg  caagccggt  atggagcgc  gggagaccc  ctatatgca  gcgctggcc  240
ccgccgcct  ctccaaagg  ggccgggtc  tggaggtgg  ctttggcat  gccatcgca  300
cgtcaaagg  gcaggaggc  cccattgat  agcattgga  catcgagtg  aatgacggc  360
tcttccagc  gctccggga  tgggcccca  ggcagacac  caaggtcat  cccttgaaa  420
gcctgtggg  ggatgtggc  cccaccctg  ctgacggtc  ctttgatgg  atcctgtac  480
acacgtacc  actctcgga  gagacctgg  acacacacc  gttcaactt  atcaagaac  540
acgcctttc  cctgctgaa  ccggggggc  tcctcacct  ctgcaacct  acctcctgg  600
gggagctga  gaagtccaa  tactcagac  tcaccatca  gtttgagga  acgcaggtg  660
ccgcgctgc  ggaggccgg  ttccggagg  agaacatcc  tacggaggt  atggcgctg  720
tcccaccgg  cgactgccg  tactacgcc  tcccacaga  gatcacgcc  ctggtgacc  780
aaggctgag  ccccacccc  gcccggcca  acccatgcc  tcctccgtg  cttcctggc  840
gggagtcca  ggtgtcgca  cagccctgg  ctgatccca  ctgtgtgtc  ccagaagct  900
tcccggctt  tctgtgagg  gtcccacca  cccagggct  atcccagct  tgtgtcacc  960
gcagctttc  cagcttctc  gtgagggtc  ctgctgccc  ctgcagggt  cctgaggtg  1020
agtaaacgc  ggcgctggg  ttggccagt  ggcagtgaa  aaaaaaaaa  aaaaaaaaa  1080
aaaaaa  1086



<210> 9305
<211> 236
<212> PRT
<213> Homo sapiens
<308> Q14353
<400> 9305

Met Ser Ala Pro Ser Ala Thr Pro Ile Phe Ala Pro Gly Glu Asn Cys 
  1               5                  10                  15
Ser Pro Ala Trp Gly Ala Ala Pro Ala Ala Tyr Asp Ala Ala Asp Thr 
             20                  25                  30
His Leu Arg Ile Leu Gly Lys Pro Val Met Glu Arg Trp Glu Thr Pro 
         35                  40                  45
Tyr Met His Ala Leu Ala Ala Ala Ala Ser Ser Lys Gly Gly Arg Val 
     50                  55                  60
Leu Glu Val Gly Phe Gly Met Ala Ile Ala Ala Ser Lys Val Gln Glu 
 65                  70                  75                  80
Ala Pro Ile Asp Glu His Trp Ile Ile Glu Cys Asn Asp Gly Val Phe 
                 85                  90                  95
Gln Arg Leu Arg Asp Trp Ala Pro Arg Gln Thr His Lys Val Ile Pro 
             100                105                110
Leu Lys Gly Leu Trp Glu Asp Val Ala Pro Thr Leu Pro Asp Gly His 
         115                120                125
Phe Asp Gly Ile Leu Tyr Asp Thr Tyr Pro Leu Ser Glu Glu Thr Trp 
     130                135                140
His Thr His Gln Phe Asn Phe Ile Lys Asn His Ala Phe Arg Leu Leu 
 145                150                155                160
Lys Pro Gly Gly Val Leu Thr Tyr Cys Asn Leu Thr Ser Trp Gly Glu 
                 165                170                175
Leu Met Lys Ser Lys Tyr Ser Asp Ile Thr Ile Met Phe Glu Glu Thr 
             180                185                190
Gln Val Pro Ala Leu Leu Glu Ala Gly Phe Arg Arg Glu Asn Ile Arg 
         195                200                205
Thr Glu Val Met Ala Leu Val Pro Pro Ala Asp Cys Arg Tyr Tyr Ala 
     210                215                220
Phe Pro Gln Met Ile Thr Pro Leu Val Thr Lys Gly 
 225                230                235



<210> 9306
<211> 4964
<212> DNA
<213> Rattus norvegicus
<308> X08056
<400> 9306

gaattctga  ctctgctct  cacacattc  ctgcccctc  gcacaacac  catgtacat  60
taaaaaaaa  taagaaaca  accaaaggg  ttggggatt  agctcagtg  tagagcgct  120
gcctaggaa  cgcaaggcc  tgggtttgg  ccccagctc  gaaaaaaag  accaaaaaa  180
aaaaaaaag  gagagaaac  aaccaaaaa  cccaaaaca  aagtgttaa  tgtttcaat  240
ctaaactgg  ggccctggt  tccactcct  gtttttagc  gttttccct  cctgtaaaa  300
gagagtact  acagttact  ctgtagcat  ttctatggg  taagagttt  actgttctt  360
tagcagttc  cagaaaaat  atcatcttc  aaaggttaa  agtttcact  ttcttctag  420
agttctcag  aaaatgatc  gatcactac  cctaacctg  ccaagtgac  caggagcta  480
agcgggtga  tgacaggtg  ggattggac  agctgggaa  gaccggctt  ttggacctc  540
ccaggccaa  gagtgtcta  acttgaggc  tccagccag  catggcggc  cacgccttt  600
atcccagca  ttcagaggt  gaatcagac  gaactcaga  aaagggcca  cttggccta  660
acagcaagc  ccaggccag  caggagctc  tgtctctaa  taaacagat  aaagagaaa  720
aaaaaaaat  aactttttg  tttgaggag  atcgtggag  gcagctagg  tcagcaagt  780
tcacagcct  ttcagacag  aagtagagt  cccttgtca  ccagccaag  aaatgcaga  840
agtcaagct  cattccaaa  gtctggtac  agggagctt  ccccgcacc  cgcagaagc  900
acaacagta  ttctttcgg  ggcactggt  ccactggta  tctctaagc  tccctccct  960
caccgcacg  acttcgccc  tcaaggcta  aacttcctg  ctagataac  aggctccgc  1020
caggcccgt  ggctccgcc  cactcataa  aaaagactg  attcagctc  acccacgaa  1080
aactacccc  gccctaggc  ggcctccta  gcgccaacc  caccctagc  gaaagctag  1140
ccggggctc  agttttgcc  ctaccaggc  aggccccac  cgtgggaga  gactaggct  1200
cgccactag  agaaggctt  gatttcatc  tatcccata  acacctacc  catggctct  1260
tcctcatcc  tagcagaaa  ctggaccat  caccgtccc  gccggctgg  cccgttcct  1320
agcttcttc  ctcatactt  gcagaaaga  gaccccacc  cattgctcc  gtcccgccc  1380
tagcagaag  ctggactct  ccctaccct  caggctcca  cctgtatgg  tcctgcctg  1440
atccctcat  caagtctgg  ttctgtcca  cccacaggt  tggccccat  catagcaaa  1500
aggttggac  cctccccag  ccaccacta  gtatgcgac  ctagagatc  ggtaccgag  1560
tcggtaccc  gggttcctc  acacccccc  tgcaggacc  atcccattc  atagatccg  1620
ccctcacag  actttactc  gggttccag  cagtagccc  taccctgag  acgctccac  1680
ctgccctca  actccatcc  cccaggccc  ggcccagta  taggctggc  accctcccg  1740
atcaaggcc  aaccctttt  taatgactg  accctccct  tcccagcaa  gcccgcccc  1800
gctaatagg  cccgccacc  ggcccagca  tggactccc  cggggcaca  aggtcccgc  1860
cccgcctca  gctcccacc  accccagtg  aaggctaaa  tcctctttg  agaggcgcc  1920
ccccacccc  cctcctcca  cctggtggt  ccgcagccg  actctcctg  cctggtgtg  1980
acagcctca  catgagttc  tctgcagcc  gcccgcttt  cgcgcctgg  gaggactgc  2040
gccccgcgt  gcgcgcggc  cccgcggcc  atgatacgt  tgacacgca  ctgcagatc  2100
tgggcaagc  agtaatgga  cgttgggag  ccccctaca  gcattcgct  gcggctgct  2160
ctgcctcca  aggtactct  cccagaaga  acggaggct  ctgtttaag  agtgtagga  2220
ttcccatgc  tgctgcatg  ctgagtttc  ttacctgag  cactgagct  ccttggggt  2280
accttggca  ggaagggaa  agtgttggc  aaatgtaga  gcaggcaag  gaagccggc  2340
ccgaactag  acttcctct  ctggggaaa  agacttcta  ttcccggag  tgggttgga  2400
ggtggatct  cggaccaca  cctcgagtg  agcttagag  acatggagg  gcgtgggac  2460
tgtgcgggt  gggaacctc  gagtttccc  aggctgttg  taagaatag  ttgggaaaa  2520
ggagcagag  ggcagctgt  cggtgctat  gccctgaac  tctggacga  gggtggtgt  2580
tgggacacc  cagcctcaa  caggtcaat  gccaaaggg  ttcaaagtt  acccggagc  2640
catgaggac  tggtatcaa  tgcggaatg  aacatggag  ggttacagt  tcgggcctc  2700
gaaccaggc  tggcccttt  taaccccac  tagggccat  gcacaaata  cgtgggtgg  2760
catgggctc  gagtccagg  atccctggg  ccaagccca  aagcacgtg  ccagtccct  2820
aggctccca  gctcgccgc  ctgattggc  gctggccag  gcccacact  tctgtgcta  2880
tttgttctg  ccacccact  ctggctggc  gtccttgag  catgtgtga  accggtcca  2940
cctaaccgt  cccctcccc  acccatgcc  gctgtagtg  ttttgtcct  ctagggggc  3000
gggtcctgg  agtgggctt  gggatggcc  ttgcagcct  cagggtgca  caggccccc  3060
taaaggaac  ctggattat  gaatgcaac  atggggtct  ccagcgtct  caaaactgg  3120
ccctgaagc  gccacataa  gtaccttct  tcactggag  aggaggctg  gagtacccc  3180
ccgggacta  ggagatcat  gggggtacc  atgtgaccc  ttatatcct  ctcttgctc  3240
cttctcctc  ccaaggttg  tcccttgaa  ggcctgtgg  aggaggagg  acctacact  3300
cctgatggt  actttgatg  gagggcact  tgggagcct  gcaaggggg  tggcctctg  3360
gtactgatt  gcagcctct  gggctatca  accctcctt  gctcagtgg  gcttgccgt  3420
aagaatgag  accagagtt  gatccccag  atgcatgtg  tgtaaggag  gaatgggtg  3480
tcataagtt  tcccctacc  caacaaatg  acctccaat  tgcactggg  acatagcct  3540
cgggaaaag  ctccatgaa  tggctagca  aggtgctaa  ggcagctgg  cgggctggg  3600
agtttggcc  ccaaggcca  gggataggt  ggatgaagc  tgggcaagg  tgtgccagc  3660
ctgactggc  ggcctgtgt  cacgctgca  gggattcta  acgacacat  tccactgtc  3720
gaagagacc  ggcacactc  ccagttcaa  tttattaag  tgggactgc  gggccgggg  3780
ccgagggcc  tggacggtc  ggtgggcag  gtgtgatat  tacagacca  cagctctct  3840
ctcatggtc  ctccacccc  tcttgtcca  gccctttct  tctctctgc  gactcatgc  3900
ttccgtttg  tgaagcctg  gggtatcct  acttactgc  acctcacgt  ctgggggga  3960
ctcatgaag  ccaagtaca  agacatcac  gccatgttt  aggtacgct  cctcatagc  4020
agtgggggc  ccgacccaa  agccaggca  tggcccggc  agtgtggtg  tgagaccca  4080
gacatgggg  agaggtcca  tcagggctt  tctgcagcc  gaacctact  ctctctgcc  4140
gtggggcgg  gcctgagag  tgcccacca  ggccatcag  acagcttcc  ttcagcgca  4200
gaggcagct  ttggcacag  aaactcctc  tgctcgaga  gcctacagc  ggcctgtgc  4260
aggatgctg  tctgagaca  agctgaggt  atcaggaaa  ctcgttgcc  gcatagaat  4320
cacactcac  ctaggccct  tcccgcatc  tcagtggtg  cctgtgacc  ctccctaca  4380
gagactcag  tgcctgcac  gctggaagc  ggcttccag  gagaaaaca  ctgtacaga  4440
gtgatggcg  tggtgcccc  agccgactg  cgctactat  ccttccctc  gatgatcac  4500
cccctggtc  ccaagcact  agcggctgg  ccagggcta  aaggagaat  tgtcctcct  4560
agtgccttt  tagctggag  gtgggctcc  gcctctcca  tatccctgc  gtgtgacat  4620
ctaacctct  cctggtacg  ccatctccc  agagctcag  agtaaaata  atgctacca  4680
gactagtag  gggttggct  gcggtgagc  ggaggtgag  cccgcatct  gttcagagc  4740
tgcctctcc  tgcctccat  gatgtggct  ttccatcac  ggtgctcag  ggcccccga  4800
ccagacatg  ccaatcaac  attgtatgt  ttcaacagt  gcccaggaa  agcctgggg  4860
ctcaccagg  tcagggtag  gagagcctc  acgggtccc  gcccagcac  cagcaagtc  4920
tgcaaccct  atggcacga  cctactctg  acatctctg  tacc  4964



<210> 9307
<211> 235
<212> PRT
<213> Rattus norvegicus
<308> CAA30845
<400> 9307

Ser Ser Ser Ala Ala Ser Pro Leu Phe Ala Pro Gly Glu Asp Cys Gly 
  1               5                  10                  15
Pro Ala Trp Arg Ala Ala Pro Ala Ala Tyr Asp Thr Ser Asp Thr His 
             20                  25                  30
Leu Gln Ile Leu Gly Lys Pro Val Met Glu Arg Trp Glu Thr Pro Tyr 
         35                  40                  45
Met His Ser Leu Ala Ala Ala Ala Ala Ser Arg Gly Gly Arg Val Leu 
     50                  55                  60
Glu Val Gly Phe Gly Met Ala Ile Ala Ala Ser Arg Val Gln Gln Ala 
 65                  70                  75                  80
Pro Ile Lys Glu His Trp Ile Ile Glu Cys Asn Asp Gly Val Phe Gln 
                 85                  90                  95
Arg Leu Gln Asn Trp Ala Leu Lys Gln Pro His Lys Val Val Pro Leu 
             100                105                110
Lys Gly Leu Trp Glu Glu Glu Ala Pro Thr Leu Pro Asp Gly His Phe 
         115                120                125
Asp Gly Ile Leu Tyr Asp Thr Tyr Pro Leu Ser Glu Glu Thr Trp His 
     130                135                140
Thr His Gln Phe Asn Phe Ile Lys Thr His Ala Phe Arg Leu Leu Lys 
 145                150                155                160
Pro Gly Gly Ile Leu Thr Tyr Cys Asn Leu Thr Ser Trp Gly Glu Leu 
                 165                170                175
Met Lys Ser Lys Tyr Thr Asp Ile Thr Ala Met Phe Glu Glu Thr Gln 
             180                185                190
Val Pro Ala Leu Leu Glu Ala Gly Phe Gln Arg Glu Asn Ile Cys Thr 
         195                200                205
Glu Val Met Ala Leu Val Pro Pro Ala Asp Cys Arg Tyr Tyr Ala Phe 
     210                215                220
Pro Gln Met Ile Thr Pro Leu Val Thr Lys His 
 225                230                235



<210> 9308
<211> 1086
<212> DNA
<213> Homo sapiens
<308> NM_000156
<400> 9308

ccccggccc  caagcccct  cagggagcg  gcccgggcg  cgcgcgatc  aggtcgggt  60
gccgtccag  ctgcagcat  agcgccccc  gcgcgaccc  catcttcgc  cccggcgag  120
actgcagcc  cgcgtgggg  gcggcgccc  cggcctacg  cgcagcgga  acgcacctg  180
gcatcctgg  caagccggt  atggagcgc  gggagaccc  ctatatgca  gcgctggcc  240
ccgccgcct  ctccaaagg  ggccgggtc  tggaggtgg  ctttggcat  gccatcgca  300
cgtcaaagg  gcaggaggc  cccattgat  agcattgga  catcgagtg  aatgacggc  360
tcttccagc  gctccggga  tgggcccca  ggcagacac  caaggtcat  cccttgaaa  420
gcctgtggg  ggatgtggc  cccaccctg  ctgacggtc  ctttgatgg  atcctgtac  480
acacgtacc  actctcgga  gagacctgg  acacacacc  gttcaactt  atcaagaac  540
acgcctttc  cctgctgaa  ccggggggc  tcctcacct  ctgcaacct  acctcctgg  600
gggagctga  gaagtccaa  tactcagac  tcaccatca  gtttgagga  acgcaggtg  660
ccgcgctgc  ggaggccgg  ttccggagg  agaacatcc  tacggaggt  atggcgctg  720
tcccaccgg  cgactgccg  tactacgcc  tcccacaga  gatcacgcc  ctggtgacc  780
aaggctgag  ccccacccc  gcccggcca  acccatgcc  tcctccgtg  cttcctggc  840
gggagtcca  ggtgtcgca  cagccctgg  ctgatccca  ctgtgtgtc  ccagaagct  900
tcccggctt  tctgtgagg  gtcccacca  cccagggct  atcccagct  tgtgtcacc  960
gcagctttc  cagcttctc  gtgagggtc  ctgctgccc  ctgcagggt  cctgaggtg  1020
agtaaacgc  ggcgctggg  ttggccagt  ggcagtgaa  aaaaaaaaa  aaaaaaaaa  1080
aaaaaa  1086



<210> 9309
<211> 236
<212> PRT
<213> Homo sapiens
<308> Q14353
<400> 9309

Met Ser Ala Pro Ser Ala Thr Pro Ile Phe Ala Pro Gly Glu Asn Cys 
  1               5                  10                  15
Ser Pro Ala Trp Gly Ala Ala Pro Ala Ala Tyr Asp Ala Ala Asp Thr 
             20                  25                  30
His Leu Arg Ile Leu Gly Lys Pro Val Met Glu Arg Trp Glu Thr Pro 
         35                  40                  45
Tyr Met His Ala Leu Ala Ala Ala Ala Ser Ser Lys Gly Gly Arg Val 
     50                  55                  60
Leu Glu Val Gly Phe Gly Met Ala Ile Ala Ala Ser Lys Val Gln Glu 
 65                  70                  75                  80
Ala Pro Ile Asp Glu His Trp Ile Ile Glu Cys Asn Asp Gly Val Phe 
                 85                  90                  95
Gln Arg Leu Arg Asp Trp Ala Pro Arg Gln Thr His Lys Val Ile Pro 
             100                105                110
Leu Lys Gly Leu Trp Glu Asp Val Ala Pro Thr Leu Pro Asp Gly His 
         115                120                125
Phe Asp Gly Ile Leu Tyr Asp Thr Tyr Pro Leu Ser Glu Glu Thr Trp 
     130                135                140
His Thr His Gln Phe Asn Phe Ile Lys Asn His Ala Phe Arg Leu Leu 
 145                150                155                160
Lys Pro Gly Gly Val Leu Thr Tyr Cys Asn Leu Thr Ser Trp Gly Glu 
                 165                170                175
Leu Met Lys Ser Lys Tyr Ser Asp Ile Thr Ile Met Phe Glu Glu Thr 
             180                185                190
Gln Val Pro Ala Leu Leu Glu Ala Gly Phe Arg Arg Glu Asn Ile Arg 
         195                200                205
Thr Glu Val Met Ala Leu Val Pro Pro Ala Asp Cys Arg Tyr Tyr Ala 
     210                215                220
Phe Pro Gln Met Ile Thr Pro Leu Val Thr Lys Gly 
 225                230                235



<210> 9310
<211> 1495
<212> DNA
<213> Rattus norvegicus
<308> X12459
<400> 9310

caatccaag  caagatgtc  agcaagggc  ctgtggttc  ggcctacag  ggtggtctg  60
acacctcct  catcctcgt  tggctgaag  aacaaggct  tgatgtcat  gcctacctg  120
ccaacattg  ccagaagga  gactttgag  aagccagga  gaaggcact  aagcttggg  180
ccaaaaagg  gttcattga  gatgtaagc  aggagtttg  ggaagagtt  atctggcct  240
ctgtccagt  cagtgcact  tatgaggac  gctatctcc  aggcacctc  ctcgccagg  300
cttgcatag  tcgcaaaca  gtggaaatt  cccagcgcg  aggggccaa  tatgtgtct  360
acggcgcca  ggggaaggg  aatgaccag  tccgctttg  gctcacctg  tactcgtta  420
caccccaga  taaggtcat  gccccctgg  ggatgcccg  gttttacaa  cggttcaag  480
gccgaaatg  tttgatgga  tacgcaaag  aacatggaa  ccccatccc  gtcaccccc  540
agagcccct  gagcatgga  gagaacctt  tgcacatca  ctacgaggc  ggaatcctg  600
aaaacccca  gaaccaagc  cctccaggt  tctacacaa  aactcagga  cctgccaaa  660
cacccaaca  cccagatgt  cttgagata  aattcaaaa  aggggtccc  gtgaaggtg  720
ccaacgtca  agatggcac  acccacagc  catccttgg  cctcttcat  tacctgaat  780
aagttgcgg  caagcatgg  gtagggcgc  ttgacatcg  ggagaaccg  ttcattgga  840
tgaagtccc  gggtatcta  gagacccca  cagggacca  cctttacca  gctcattta  900
acatagagg  cttcaccat  gatcgggaa  tacgcaaaa  caagcaggg  ctgggcctc  960
aattcgcag  gctcgtata  accggtttc  ggcacagcc  tgaatgtga  tttgttcgc  1020
actgcatcg  caagtccca  gaacgggtg  aaggaaagg  gcaggtatc  gtcttcaag  1080
gccaggtgt  catccttgg  cgggagtct  cactttcac  atacaatga  gagctggtg  1140
gcatgaacg  acagggtga  tatgaaccc  ttgatgcca  cggcttcat  aatatcaac  1200
cgctcaggc  gaaggagta  catcgcctt  agagcaagg  caccgccaa  tagaccgtg  1260
caaagaggc  gggcctccc  gctctgcag  tctcccagg  tccagcatt  attgttgtg  1320
taaatttgt  attgtagct  gttctccta  cacctgact  gggctgctg  gccccccct  1380
acctccccc  cacccacag  ctttgttcc  tggtcccct  tagcctaca  aagtggtca  1440
cgaagggaa  ggggggtgg  aggcagctg  agaaagcgc  taaaatgac  attaa  1495



<210> 9311
<211> 412
<212> PRT
<213> Rattus norvegicus
<308> P09034
<400> 9311

Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp 
  1               5                  10                  15
Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile 
             20                  25                  30
Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg 
         35                  40                  45
Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val 
     50                  55                  60
Ser Lys Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Val Gln Ser Ser 
 65                  70                  75                  80
Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala Arg Pro 
                 85                  90                  95
Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys 
             100                105                110
Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe 
         115                120                125
Glu Leu Thr Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile Ala Pro 
     130                135                140
Trp Arg Met Pro Glu Phe Tyr Asn Arg Phe Lys Gly Arg Asn Asp Leu 
 145                150                155                160
Met Glu Tyr Ala Lys Gln His Gly Ile Pro Ile Pro Val Thr Pro Lys 
                 165                170                175
Ser Pro Trp Ser Met Asp Glu Asn Leu Met His Ile Ser Tyr Glu Ala 
             180                185                190
Gly Ile Leu Glu Asn Pro Lys Asn Gln Ala Pro Pro Gly Leu Tyr Thr 
         195                200                205
Lys Thr Gln Asp Pro Ala Lys Ala Pro Asn Thr Pro Asp Val Leu Glu 
     210                215                220
Ile Glu Phe Lys Lys Gly Val Pro Val Lys Val Thr Asn Val Lys Asp 
 225                230                235                240
Gly Thr Thr His Ser Thr Ser Leu Asp Leu Phe Met Tyr Leu Asn Glu 
                 245                250                255
Val Ala Gly Lys His Gly Val Gly Arg Ile Asp Ile Val Glu Asn Arg 
             260                265                270
Phe Ile Gly Met Lys Ser Arg Gly Ile Tyr Glu Thr Pro Ala Gly Thr 
         275                280                285
Ile Leu Tyr His Ala His Leu Asp Ile Glu Ala Phe Thr Met Asp Arg 
     290                295                300
Glu Val Arg Lys Ile Lys Gln Gly Leu Gly Leu Lys Phe Ala Glu Leu 
 305                310                315                320
Val Tyr Thr Gly Phe Trp His Ser Pro Glu Cys Glu Phe Val Arg His 
                 325                330                335
Cys Ile Asp Lys Ser Gln Glu Arg Val Glu Gly Lys Val Gln Val Ser 
             340                345                350
Val Phe Lys Gly Gln Val Tyr Ile Leu Gly Arg Glu Ser Pro Leu Ser 
         355                360                365
Leu Tyr Asn Glu Glu Leu Val Ser Met Asn Val Gln Gly Asp Tyr Glu 
     370                375                380
Pro Ile Asp Ala Thr Gly Phe Ile Asn Ile Asn Ser Leu Arg Leu Lys 
 385                390                395                400
Glu Tyr His Arg Leu Gln Ser Lys Val Thr Ala Lys 
                 405                410



<210> 9313
<211> 412
<212> PRT
<213> Homo sapiens
<308> P00966
<400> 9313

Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp 
  1               5                  10                  15
Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile 
             20                  25                  30
Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg 
         35                  40                  45
Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val 
     50                  55                  60
Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser 
 65                  70                  75                  80
Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala Arg Pro 
                 85                  90                  95
Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys 
             100                105                110
Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe 
         115                120                125
Glu Leu Ser Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile Ala Pro 
     130                135                140
Trp Arg Met Pro Glu Phe Tyr Asn Arg Phe Lys Gly Arg Asn Asp Leu 
 145                150                155                160
Met Glu Tyr Ala Lys Gln His Gly Ile Pro Ile Pro Val Thr Pro Lys 
                 165                170                175
Asn Pro Trp Ser Met Asp Glu Asn Leu Met His Ile Ser Tyr Glu Ala 
             180                185                190
Gly Ile Leu Glu Asn Pro Lys Asn Gln Ala Pro Pro Gly Leu Tyr Thr 
         195                200                205
Lys Thr Gln Asp Pro Ala Lys Ala Pro Asn Thr Pro Asp Ile Leu Glu 
     210                215                220
Ile Glu Phe Lys Lys Gly Val Pro Val Lys Val Thr Asn Val Lys Asp 
 225                230                235                240
Gly Thr Thr His Gln Thr Ser Leu Glu Leu Phe Met Tyr Leu Asn Glu 
                 245                250                255
Val Ala Gly Lys His Gly Val Gly Arg Ile Asp Ile Val Glu Asn Arg 
             260                265                270
Phe Ile Gly Met Lys Ser Arg Gly Ile Tyr Glu Thr Pro Ala Gly Thr 
         275                280                285
Ile Leu Tyr His Ala His Leu Asp Ile Glu Ala Phe Thr Met Asp Arg 
     290                295                300
Glu Val Arg Lys Ile Lys Gln Gly Leu Gly Leu Lys Phe Ala Glu Leu 
 305                310                315                320
Val Tyr Thr Gly Phe Trp His Ser Pro Glu Cys Glu Phe Val Arg His 
                 325                330                335
Cys Ile Ala Lys Ser Gln Glu Arg Val Glu Gly Lys Val Gln Val Ser 
             340                345                350
Val Leu Lys Gly Gln Val Tyr Ile Leu Gly Arg Glu Ser Pro Leu Ser 
         355                360                365
Leu Tyr Asn Glu Glu Leu Val Ser Met Asn Val Gln Gly Asp Tyr Glu 
     370                375                380
Pro Thr Asp Ala Thr Gly Phe Ile Asn Ile Asn Ser Leu Arg Leu Lys 
 385                390                395                400
Glu Tyr His Arg Leu Gln Ser Lys Val Thr Ala Lys 
                 405                410



<210> 9314
<211> 1269
<212> DNA
<213> Rattus norvegicus
<308> X12535
<400> 9314

tggcgttgt  tctcctcct  tgttgaccc  gcgcttcaa  gatgacctc  aggaagaaa  60
tgttgctga  ggtcatcat  ctgggagac  ctggtgttg  aaagacatc  ctcatgaac  120
agtatgtga  taagaagtt  agtaaccag  acaaagcca  aataggagc  gactttctg  180
ccaaggagg  gatggtgga  gacagactt  ttaccatgc  gatctggga  acagctggt  240
aagaacggt  ccagtctct  ggtgtggcc  tctacagag  tgcagattg  tgcgttctg  300
tgtttgatg  gactgcccc  aacacattc  aaacccttg  cagctggag  gacgagttt  360
tcatccagg  cagcccccg  gatcctgag  acttccctt  tgttgtgtt  ggaaacaag  420
ttgacctgg  aaacagaca  gtggccaca  agagggcac  ggcttggtg  tacagcaaa  480
acaacattc  ttacttcga  accagtgcc  aggaggcca  caatgtgga  caggccttc  540
agacaattg  tcggaatgc  cttaaacag  aaacggaag  ggagctgta  aatgaattc  600
ctgaaccca  caaactgga  aagaacgag  gggccaagg  ctccgcaga  agctgcagc  660
gttgaagag  cagtgagca  agagcacag  gtccttcac  gaccaagaa  acacacgta  720
gccttcaac  cgcgtccct  ctcctctaa  cagaccaga  cgtgagctc  cacatccag  780
tgccaaaag  aactccaca  acacacata  acacatgca  acacacaca  acatacaca  840
acagcaagc  atcaccgcc  gtgcctgtc  gggctcctg  ggacgtctg  caccgtgag  900
ctgtgtatg  acatatggc  gagaccctg  gtgctctgg  gtgcgtggg  agccggaag  960
ttactcttt  tgtccactg  aaagtgaga  aactgttca  agttcatct  tgtctaatt  1020
tctgatttt  tttttaacg  tcttgtggt  ttttacccc  accctcctt  aaggtcctg  1080
gggaaggct  gtgcccagg  tccgttctg  gcaggctgt  ttgtatgta  ctgttaatg  1140
ttgttactt  taatcaatc  gatcttttt  cagtatcca  ttattatgt  atgcttctt  1200
gaaaagaat  ttatagtac  tgttaatat  tgcaaccaa  taaaatgta  aaattagtg  1260
aaggaattc  1269



<210> 9315
<211> 207
<212> PRT
<213> Rattus norvegicus
<308> CAA31053
<400> 9315

Met Thr Ser Arg Lys Lys Val Leu Leu Lys Val Ile Ile Leu Gly Asp 
  1               5                  10                  15
Ser Gly Val Gly Lys Thr Ser Leu Met Asn Gln Tyr Val Asn Lys Lys 
             20                  25                  30
Phe Ser Asn Gln Tyr Lys Ala Thr Ile Gly Ala Asp Phe Leu Thr Lys 
         35                  40                  45
Glu Val Met Val Asp Asp Arg Leu Val Thr Met Gln Ile Trp Asp Thr 
     50                  55                  60
Ala Gly Gln Glu Arg Phe Gln Ser Leu Gly Val Ala Phe Tyr Arg Gly 
 65                  70                  75                  80
Ala Asp Cys Cys Val Leu Val Phe Asp Val Thr Ala Pro Asn Thr Phe 
                 85                  90                  95
Lys Thr Leu Asp Ser Trp Arg Asp Glu Phe Leu Ile Gln Ala Ser Pro 
             100                105                110
Arg Asp Pro Glu Asn Phe Pro Phe Val Val Leu Gly Asn Lys Ile Asp 
         115                120                125
Leu Glu Asn Arg Gln Val Ala Thr Lys Arg Ala Gln Ala Trp Cys Tyr 
     130                135                140
Ser Lys Asn Asn Ile Pro Tyr Phe Glu Thr Ser Ala Lys Glu Ala Ile 
 145                150                155                160
Asn Val Glu Gln Ala Phe Gln Thr Ile Ala Arg Asn Ala Leu Lys Gln 
                 165                170                175
Glu Thr Glu Val Glu Leu Tyr Asn Glu Phe Pro Glu Pro Ile Lys Leu 
             180                185                190
Asp Lys Asn Glu Arg Ala Lys Ala Ser Ala Glu Ser Cys Ser Cys 
         195                200                205



<210> 9316
<211> 1269
<212> DNA
<213> Rattus norvegicus
<308> X12535
<400> 9316

tggcgttgt  tctcctcct  tgttgaccc  gcgcttcaa  gatgacctc  aggaagaaa  60
tgttgctga  ggtcatcat  ctgggagac  ctggtgttg  aaagacatc  ctcatgaac  120
agtatgtga  taagaagtt  agtaaccag  acaaagcca  aataggagc  gactttctg  180
ccaaggagg  gatggtgga  gacagactt  ttaccatgc  gatctggga  acagctggt  240
aagaacggt  ccagtctct  ggtgtggcc  tctacagag  tgcagattg  tgcgttctg  300
tgtttgatg  gactgcccc  aacacattc  aaacccttg  cagctggag  gacgagttt  360
tcatccagg  cagcccccg  gatcctgag  acttccctt  tgttgtgtt  ggaaacaag  420
ttgacctgg  aaacagaca  gtggccaca  agagggcac  ggcttggtg  tacagcaaa  480
acaacattc  ttacttcga  accagtgcc  aggaggcca  caatgtgga  caggccttc  540
agacaattg  tcggaatgc  cttaaacag  aaacggaag  ggagctgta  aatgaattc  600
ctgaaccca  caaactgga  aagaacgag  gggccaagg  ctccgcaga  agctgcagc  660
gttgaagag  cagtgagca  agagcacag  gtccttcac  gaccaagaa  acacacgta  720
gccttcaac  cgcgtccct  ctcctctaa  cagaccaga  cgtgagctc  cacatccag  780
tgccaaaag  aactccaca  acacacata  acacatgca  acacacaca  acatacaca  840
acagcaagc  atcaccgcc  gtgcctgtc  gggctcctg  ggacgtctg  caccgtgag  900
ctgtgtatg  acatatggc  gagaccctg  gtgctctgg  gtgcgtggg  agccggaag  960
ttactcttt  tgtccactg  aaagtgaga  aactgttca  agttcatct  tgtctaatt  1020
tctgatttt  tttttaacg  tcttgtggt  ttttacccc  accctcctt  aaggtcctg  1080
gggaaggct  gtgcccagg  tccgttctg  gcaggctgt  ttgtatgta  ctgttaatg  1140
ttgttactt  taatcaatc  gatcttttt  cagtatcca  ttattatgt  atgcttctt  1200
gaaaagaat  ttatagtac  tgttaatat  tgcaaccaa  taaaatgta  aaattagtg  1260
aaggaattc  1269



<210> 9317
<211> 207
<212> PRT
<213> Rattus norvegicus
<308> CAA31053
<400> 9317

Met Thr Ser Arg Lys Lys Val Leu Leu Lys Val Ile Ile Leu Gly Asp 
  1               5                  10                  15
Ser Gly Val Gly Lys Thr Ser Leu Met Asn Gln Tyr Val Asn Lys Lys 
             20                  25                  30
Phe Ser Asn Gln Tyr Lys Ala Thr Ile Gly Ala Asp Phe Leu Thr Lys 
         35                  40                  45
Glu Val Met Val Asp Asp Arg Leu Val Thr Met Gln Ile Trp Asp Thr 
     50                  55                  60
Ala Gly Gln Glu Arg Phe Gln Ser Leu Gly Val Ala Phe Tyr Arg Gly 
 65                  70                  75                  80
Ala Asp Cys Cys Val Leu Val Phe Asp Val Thr Ala Pro Asn Thr Phe 
                 85                  90                  95
Lys Thr Leu Asp Ser Trp Arg Asp Glu Phe Leu Ile Gln Ala Ser Pro 
             100                105                110
Arg Asp Pro Glu Asn Phe Pro Phe Val Val Leu Gly Asn Lys Ile Asp 
         115                120                125
Leu Glu Asn Arg Gln Val Ala Thr Lys Arg Ala Gln Ala Trp Cys Tyr 
     130                135                140
Ser Lys Asn Asn Ile Pro Tyr Phe Glu Thr Ser Ala Lys Glu Ala Ile 
 145                150                155                160
Asn Val Glu Gln Ala Phe Gln Thr Ile Ala Arg Asn Ala Leu Lys Gln 
                 165                170                175
Glu Thr Glu Val Glu Leu Tyr Asn Glu Phe Pro Glu Pro Ile Lys Leu 
             180                185                190
Asp Lys Asn Glu Arg Ala Lys Ala Ser Ala Glu Ser Cys Ser Cys 
         195                200                205



<210> 9318
<211> 1422
<212> DNA
<213> Rattus norvegicus
<308> X13016
<400> 9318

gtctccagt  tcacaggca  cttctcaaa  tattatgta  ttcaaaaaa  ggagatggt  60
tctgatcct  gaatcgctt  tgctgtctt  ggtaactgg  tttcaagat  aatcagtac  120
aaatgtaaa  gccataacc  gcagcaacg  aaccctgac  atcctgaag  acccacttg  180
atcgtatca  cgtctcacc  ggcttcata  taccaacca  aagatttta  agtacttcc  240
taatggtaa  aaaactgtc  tcgagtctg  atttaaaga  agggtcgat  ttgacaaaa  300
aaatggtgc  cttcgtatc  ataatgtct  gaaagagga  agaggtgac  actacatga  360
aatgttgca  gaaactgag  accagtgga  gataaccat  gaagtatac  atcttgtgt  420
caagcctgc  atcaaaatc  agaagacta  aaatttgac  gactcctgt  acctgaggc  480
atcatgtaa  gtagaggac  aaggtgttg  ctatacttg  tatgaggac  cggggccct  540
tccccaaag  aatccagga  atgtactcg  aatcaccat  actccacac  acaagtcta  600
attttacac  tgccaagtc  gcaatcctg  aagcagcga  aacgacaca  tgtacttta  660
tccaccttg  acgctggcc  gatcttctg  agtccattg  attgcagct  ggctagtgg  720
cacgttatc  atcattccc  gcatcctgc  agcctgaca  gatctctcc  cagtcaaga  780
ggaaacatc  aagccgtat  ttgccttca  cccctgcac  gctcctaac  attgacgct  840
ctctggctc  gtggagcaa  ggaaagtgt  ttattgtta  ctgtgctgg  ttgaatgca  900
gctctatgg  gtaagcaca  gacctagta  agtgctaca  cactgatct  tacaaagat  960
ctaagctaa  tttttaaaa  ctgggggta  catctaatt  tatataccc  agttgtttc  1020
taacattca  tgaagataa  tgcattcct  ttaccaaaa  atgtggcta  cttatacta  1080
tgttgttta  atcactctt  ttttataaa  ataaatgca  tcctttacc  aaatatgtg  1140
ctatatcat  ctaatgttg  ttatatcac  cctttttgt  aagataaat  cattccttt  1200
accaaaata  gtgactatg  catgctaat  ttgtttata  cactctttt  tataaagat  1260
aatgcattc  ttttaccaa  aacatgtgg  tatattata  taatgttgt  tatatcact  1320
ttttttata  agataaatg  attccttct  ccaaaatat  tgactatat  atgctaatg  1380
tgtttatat  accttttta  aaataaaat  ttttcacat  ct  1422



<210> 9319
<211> 240
<212> PRT
<213> Rattus norvegicus
<308> P10252
<400> 9319

Met Tyr Phe Lys Lys Arg Arg Trp Phe Leu Ile Leu Glu Ser Leu Leu 
  1               5                  10                  15
Leu Ser Leu Val Thr Gly Phe Gln Asp Gln Ser Val Pro Asn Val Asn 
             20                  25                  30
Ala Ile Thr Gly Ser Asn Val Thr Leu Thr Ile Leu Lys His Pro Leu 
         35                  40                  45
Ala Ser Tyr Gln Arg Leu Thr Trp Leu His Thr Thr Asn Gln Lys Ile 
     50                  55                  60
Leu Glu Tyr Phe Pro Asn Gly Lys Lys Thr Val Phe Glu Ser Val Phe 
 65                  70                  75                  80
Lys Asp Arg Val Asp Leu Asp Lys Thr Asn Gly Ala Leu Arg Ile Tyr 
                 85                  90                  95
Asn Val Ser Lys Glu Asp Arg Gly Asp Tyr Tyr Met Arg Met Leu His 
             100                105                110
Glu Thr Glu Asp Gln Trp Lys Ile Thr Met Glu Val Tyr Asp Leu Val 
         115                120                125
Ser Lys Pro Ala Ile Lys Ile Glu Lys Thr Lys Asn Leu Thr Asp Ser 
     130                135                140
Cys His Leu Arg Leu Ser Cys Lys Val Glu Asp Gln Gly Val Asp Tyr 
 145                150                155                160
Thr Trp Tyr Glu Asp Ser Gly Pro Phe Pro Gln Arg Asn Pro Gly Tyr 
                 165                170                175
Val Leu Glu Ile Thr Ile Thr Pro His Asn Lys Ser Thr Phe Tyr Thr 
             180                185                190
Cys Gln Val Ser Asn Pro Val Ser Ser Glu Asn Asp Thr Leu Tyr Phe 
         195                200                205
Ile Pro Pro Cys Thr Leu Ala Arg Ser Ser Gly Val His Trp Ile Ala 
     210                215                220
Ala Trp Leu Val Val Thr Leu Ser Ile Ile Pro Ser Ile Leu Leu Ala 
 225                230                235                240



<210> 9320
<211> 1058
<212> DNA
<213> Homo sapiens
<308> M37766
<400> 9320

gggaagttc  ggaaggaag  atgtgctcc  gaggttggg  ttcgtgtct  gctctggaa  60
tgctactgc  gcctctgtc  ctcctggtg  ccagcattc  aggtcactt  gtacatatg  120
ccgtggtct  cggcagcaa  gtgactctg  acatctctg  gagcctgcc  gagaactac  180
aacaactaa  ctggtttta  actttcgac  agaagattg  agaatggga  tccagaaaa  240
ctaagtact  tgaatccaa  tttaaaggc  gggtcagac  tgatcctca  agtggcgca  300
tgtacatct  taaggtcca  aaagaggac  acagcacct  catcatgag  gtgttgaaa  360
agactggga  tgagcaaga  tggaagatc  agctgcaag  gcttgaccc  gtacccaag  420
ctgtcatca  aattgagaa  atagaagac  tggatgaca  ctgttatct  aaactgtca  480
gtgtgatac  tggcgagtc  gtaaactac  cctggtatg  ggacaaaag  cccttccca  540
aggagctcc  gaacagtgt  cttgaaacc  cccttatgc  acataatta  tccaggtgt  600
atacttgcc  agtcagcaa  tctgtgagc  gcaagaatg  caccgtctg  ctcagtcca  660
cctgtaccc  ggcccggtc  tttggagta  aatggattg  aagttggct  gtggtcacg  720
tgcccacca  tcttggcct  ttacttacc  gagatgagc  cttttaact  aagcgaaac  780
tcaaggcca  aagatcttg  ctgttggtg  tcatgctcc  caccaggac  gagactgta  840
aggctgacc  gaagcatgc  gctgaatta  caacgagga  tttcaagtt  acttttaaa  900
actggttat  atttaattt  atatccctt  gttgttttc  agtacacag  gatatagag  960
tacacatgc  tttttccca  ccaaaattg  gacaacatt  tgtgaatgt  ttattattt  1020
ttaaaataa  catttgata  aattatcaa  taactgaa  1058



<210> 9321
<211> 243
<212> PRT
<213> Homo sapiens
<308> P09326
<400> 9321

Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
  1               5                  10                  15
Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
             20                  25                  30
Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
         35                  40                  45
Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
     50                  55                  60
Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
 65                  70                  75                  80
Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                 85                  90                  95
Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
             100                105                110
Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
         115                120                125
Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
     130                135                140
Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
 145                150                155                160
Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                 165                170                175
Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn Tyr Ser Arg 
             180                185                190
Cys Tyr Thr Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Thr 
         195                200                205
Val Cys Leu Ser Pro Pro Cys Thr Leu Ala Arg Ser Phe Gly Val Glu 
     210                215                220
Trp Ile Ala Ser Trp Leu Val Val Thr Val Pro Thr Ile Leu Gly Leu 
 225                230                235                240
Leu Leu Thr 
                 245



<210> 9322
<211> 1150
<212> DNA
<213> Rattus norvegicus
<308> X13044
<400> 9322

gcagcagca  cagcaccag  agcacttgg  ggaaaagct  gaggctaga  tcatggatg  60
ccagcgcga  ctcatctct  accatgagc  gctgcccat  ctgggccag  gtgctagag  120
cccagaaag  aattgcaac  gtggagtcc  gtacaccag  gtctctgtc  tggtggctc  180
gctcttggc  gggcaggcc  ccactgctt  cttcctgta  cagcagcag  gccgcctgg  240
caagctgac  gtcacctcc  agaacctgc  actggagaa  cttcgcatg  agcttccga  300
atctgccaa  cctgtgagc  cgatgcgca  ggctactcc  ttgctgatg  gcccactgt  360
catggataa  atgctccaa  cgcccgtga  gaatgttac  aagtatggc  acatgaccc  420
ggaccacgt  atgcacctg  ttacgaagt  tggacccgt  aactaccca  agctgaagg  480
gagcttccc  gagaatctg  agcacctta  gaactctat  aatggtctg  actggaagg  540
ctttgagag  tggatgaaa  agtggctgt  gtttgaaat  agcaagaac  ccctggagg  600
gaagcagcc  acccagact  cacctaaag  gccactgga  atggaagac  catcttctg  660
cctgggagt  accaagcag  atatgggcc  aatgttctt  tgaagacag  agccagctc  720
gcacggcgg  acgtcccct  ctcctcagc  cttcttaca  tccctaaca  cacacccat  780
ccgtcttcc  gcacctggg  ttgagactg  tatctgctt  accgtccct  acacaacaa  840
tgaaaccgg  acagaatga  aacactgga  ggagggcct  gctgcctac  cccatctaa  900
ggaccccca  ttctgaccc  ttagcagtc  ttaatgtgg  gctctgaga  ctaggccca  960
tgacaggga  aggggatgc  ctaccctta  tctaggctg  atacatttg  tgtcttctc  1020
aggaagagg  caagccctc  cagcaaccc  tcctcatgt  ctgccgacg  ccctgggat  1080
cctgctcag  caagcttgt  agcagcctg  aggaccatg  ttcacgtga  aataaaagg  1140
agaaggtaaa  1150



<210> 9323
<211> 280
<212> PRT
<213> Rattus norvegicus
<308> P10247
<400> 9323

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
  1               5                  10                  15
Leu Gly Gln Arg Ala Arg Ala Pro Glu Ser Asn Cys Asn Arg Gly Val 
             20                  25                  30
Leu Tyr Thr Ser Val Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln 
         35                  40                  45
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
     50                  55                  60
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
 65                  70                  75                  80
Leu Pro Lys Ser Ala Lys Pro Val Ser Pro Met Arg Met Ala Thr Pro 
                 85                  90                  95
Leu Leu Met Arg Pro Leu Ser Met Asp Asn Met Leu Gln Ala Pro Val 
             100                105                110
Lys Asn Val Thr Lys Tyr Gly Asn Met Thr Gln Asp His Val Met His 
         115                120                125
Leu Leu Thr Lys Ser Gly Pro Val Asn Tyr Pro Gln Leu Lys Gly Ser 
     130                135                140
Phe Pro Glu Asn Leu Lys His Leu Lys Asn Ser Met Asn Gly Leu Asp 
 145                150                155                160
Trp Lys Val Phe Glu Ser Trp Met Lys Gln Trp Leu Leu Phe Glu Met 
                 165                170                175
Ser Lys Asn Ser Leu Glu Glu Lys Gln Pro Thr Gln Thr Pro Pro Lys 
             180                185                190
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Asp Val His 
         195                200                205
Pro Gly Ala Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Met Pro 
     210                215                220
Leu Gln Cys His Gly Ser Thr Gly Tyr Cys Trp Cys Val Phe Pro Asn 
 225                230                235                240
Gly Thr Glu Val Pro His Thr Lys Ser Arg Gly Arg His Asn Cys Ser 
                 245                250                255
Glu Pro Leu Asp Met Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
             260                265                270
Gln Asp Met Gly Gln Met Phe Leu 
         275                280



<210> 9324
<211> 1304
<212> DNA
<213> Homo sapiens
<308> NM_004355
<400> 9324

ttcccagat  cacaggagg  gaagcagga  ctgtcggga  gatcagaag  cagtcatgg  60
tgaccagcg  gaccttatc  ccaacaatg  gcaactgcc  atgctgggc  ggcgccctg  120
ggccccgga  agcaagtgc  gccgcggag  cctgtacac  ggcttttcc  tcctggtga  180
tctgctcct  gctggccag  ccaccaccg  ctacttcct  taccagcag  agggccggc  240
ggacaaact  acagtcacc  cccagaacc  gcagctgga  aacctgcgc  tgaagcttc  300
caagcctcc  aagcctgtg  gcaagatgc  catggccac  ccgctgctg  tgcaggcgc  360
gcccatggg  gccctgccc  aggggccca  gcagaatgc  accaagtat  gcaacatga  420
agaggacca  gtgatgcac  tgctccaga  tgctgaccc  ctgaaggtg  acccgccac  480
gaaggggag  ttcccggag  acctgagac  ccttaagaa  accatggag  ccatagact  540
gaaggtctt  gagagctgg  tgcaccatt  gctcctgtt  gaaatgagc  ggcactcct  600
ggagcaaaa  cccactgac  ctccaccga  agagtcact  gaactggag  acccgtctt  660
tgggctggg  gtgaccaag  aggatctgg  cccagtccc  atgtgagag  agcagaggc  720
gtcttcaac  tcctgccag  cccacacag  tacagcttt  ttgctccct  cagccccca  780
cccctcccc  atgtcccac  ctgtacctc  tcccatgag  cctggtgcc  ggctctttc  840
tcacccttg  acaagacaa  ccaagtcgg  acagcagat  acaatgcag  aaggccctg  900
tgcccaatc  ccatctgtc  acaggggcg  gaggtccca  gaagtggcc  aaagctaga  960
agatccccg  tcctgacat  acagcagcc  ccaacacaa  gctccaaga  ctaggctca  1020
ggacgagat  ggaaggcac  gggagaagg  ataacccta  acccagacc  caggctgga  1080
atgctgact  tcctctccc  tccagcctt  ggccttggc  tttctagcc  atttacctg  1140
aggctgagc  actctcttc  ctttcccca  catcactcc  caaggaaga  ccaatgttt  1200
ggacccata  tcctttctg  cgaccccta  ttccctctg  tcagccaag  ttgttatca  1260
ctttcaggg  catggttca  attagaata  aaggtagta  ttag  1304



<210> 9325
<211> 296
<212> PRT
<213> Homo sapiens
<308> P04233
<400> 9325

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
  1               5                  10                  15
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
             20                  25                  30
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
         35                  40                  45
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
     50                  55                  60
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
 65                  70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                 85                  90                  95
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
             100                105                110
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
         115                120                125
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
     130                135                140
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
 145                150                155                160
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                 165                170                175
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
             180                185                190
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
         195                200                205
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
     210                215                220
Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
 225                230                235                240
Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                 245                250                255
Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
             260                265                270
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
         275                280                285
Gln Asp Leu Gly Pro Val Pro Met 
     290                295



<210> 9326
<211> 1150
<212> DNA
<213> Rattus norvegicus
<308> X13044
<400> 9326

gcagcagca  cagcaccag  agcacttgg  ggaaaagct  gaggctaga  tcatggatg  60
ccagcgcga  ctcatctct  accatgagc  gctgcccat  ctgggccag  gtgctagag  120
cccagaaag  aattgcaac  gtggagtcc  gtacaccag  gtctctgtc  tggtggctc  180
gctcttggc  gggcaggcc  ccactgctt  cttcctgta  cagcagcag  gccgcctgg  240
caagctgac  gtcacctcc  agaacctgc  actggagaa  cttcgcatg  agcttccga  300
atctgccaa  cctgtgagc  cgatgcgca  ggctactcc  ttgctgatg  gcccactgt  360
catggataa  atgctccaa  cgcccgtga  gaatgttac  aagtatggc  acatgaccc  420
ggaccacgt  atgcacctg  ttacgaagt  tggacccgt  aactaccca  agctgaagg  480
gagcttccc  gagaatctg  agcacctta  gaactctat  aatggtctg  actggaagg  540
ctttgagag  tggatgaaa  agtggctgt  gtttgaaat  agcaagaac  ccctggagg  600
gaagcagcc  acccagact  cacctaaag  gccactgga  atggaagac  catcttctg  660
cctgggagt  accaagcag  atatgggcc  aatgttctt  tgaagacag  agccagctc  720
gcacggcgg  acgtcccct  ctcctcagc  cttcttaca  tccctaaca  cacacccat  780
ccgtcttcc  gcacctggg  ttgagactg  tatctgctt  accgtccct  acacaacaa  840
tgaaaccgg  acagaatga  aacactgga  ggagggcct  gctgcctac  cccatctaa  900
ggaccccca  ttctgaccc  ttagcagtc  ttaatgtgg  gctctgaga  ctaggccca  960
tgacaggga  aggggatgc  ctaccctta  tctaggctg  atacatttg  tgtcttctc  1020
aggaagagg  caagccctc  cagcaaccc  tcctcatgt  ctgccgacg  ccctgggat  1080
cctgctcag  caagcttgt  agcagcctg  aggaccatg  ttcacgtga  aataaaagg  1140
agaaggtaaa  1150



<210> 9327
<211> 280
<212> PRT
<213> Rattus norvegicus
<308> P10247
<400> 9327

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
  1               5                  10                  15
Leu Gly Gln Arg Ala Arg Ala Pro Glu Ser Asn Cys Asn Arg Gly Val 
             20                  25                  30
Leu Tyr Thr Ser Val Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln 
         35                  40                  45
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
     50                  55                  60
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
 65                  70                  75                  80
Leu Pro Lys Ser Ala Lys Pro Val Ser Pro Met Arg Met Ala Thr Pro 
                 85                  90                  95
Leu Leu Met Arg Pro Leu Ser Met Asp Asn Met Leu Gln Ala Pro Val 
             100                105                110
Lys Asn Val Thr Lys Tyr Gly Asn Met Thr Gln Asp His Val Met His 
         115                120                125
Leu Leu Thr Lys Ser Gly Pro Val Asn Tyr Pro Gln Leu Lys Gly Ser 
     130                135                140
Phe Pro Glu Asn Leu Lys His Leu Lys Asn Ser Met Asn Gly Leu Asp 
 145                150                155                160
Trp Lys Val Phe Glu Ser Trp Met Lys Gln Trp Leu Leu Phe Glu Met 
                 165                170                175
Ser Lys Asn Ser Leu Glu Glu Lys Gln Pro Thr Gln Thr Pro Pro Lys 
             180                185                190
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Asp Val His 
         195                200                205
Pro Gly Ala Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Met Pro 
     210                215                220
Leu Gln Cys His Gly Ser Thr Gly Tyr Cys Trp Cys Val Phe Pro Asn 
 225                230                235                240
Gly Thr Glu Val Pro His Thr Lys Ser Arg Gly Arg His Asn Cys Ser 
                 245                250                255
Glu Pro Leu Asp Met Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
             260                265                270
Gln Asp Met Gly Gln Met Phe Leu 
         275                280



<210> 9328
<211> 1304
<212> DNA
<213> Homo sapiens
<308> NM_004355
<400> 9328

ttcccagat  cacaggagg  gaagcagga  ctgtcggga  gatcagaag  cagtcatgg  60
tgaccagcg  gaccttatc  ccaacaatg  gcaactgcc  atgctgggc  ggcgccctg  120
ggccccgga  agcaagtgc  gccgcggag  cctgtacac  ggcttttcc  tcctggtga  180
tctgctcct  gctggccag  ccaccaccg  ctacttcct  taccagcag  agggccggc  240
ggacaaact  acagtcacc  cccagaacc  gcagctgga  aacctgcgc  tgaagcttc  300
caagcctcc  aagcctgtg  gcaagatgc  catggccac  ccgctgctg  tgcaggcgc  360
gcccatggg  gccctgccc  aggggccca  gcagaatgc  accaagtat  gcaacatga  420
agaggacca  gtgatgcac  tgctccaga  tgctgaccc  ctgaaggtg  acccgccac  480
gaaggggag  ttcccggag  acctgagac  ccttaagaa  accatggag  ccatagact  540
gaaggtctt  gagagctgg  tgcaccatt  gctcctgtt  gaaatgagc  ggcactcct  600
ggagcaaaa  cccactgac  ctccaccga  agagtcact  gaactggag  acccgtctt  660
tgggctggg  gtgaccaag  aggatctgg  cccagtccc  atgtgagag  agcagaggc  720
gtcttcaac  tcctgccag  cccacacag  tacagcttt  ttgctccct  cagccccca  780
cccctcccc  atgtcccac  ctgtacctc  tcccatgag  cctggtgcc  ggctctttc  840
tcacccttg  acaagacaa  ccaagtcgg  acagcagat  acaatgcag  aaggccctg  900
tgcccaatc  ccatctgtc  acaggggcg  gaggtccca  gaagtggcc  aaagctaga  960
agatccccg  tcctgacat  acagcagcc  ccaacacaa  gctccaaga  ctaggctca  1020
ggacgagat  ggaaggcac  gggagaagg  ataacccta  acccagacc  caggctgga  1080
atgctgact  tcctctccc  tccagcctt  ggccttggc  tttctagcc  atttacctg  1140
aggctgagc  actctcttc  ctttcccca  catcactcc  caaggaaga  ccaatgttt  1200
ggacccata  tcctttctg  cgaccccta  ttccctctg  tcagccaag  ttgttatca  1260
ctttcaggg  catggttca  attagaata  aaggtagta  ttag  1304



<210> 9329
<211> 296
<212> PRT
<213> Homo sapiens
<308> P04233
<400> 9329

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
  1               5                  10                  15
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
             20                  25                  30
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
         35                  40                  45
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
     50                  55                  60
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
 65                  70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                 85                  90                  95
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
             100                105                110
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
         115                120                125
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
     130                135                140
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
 145                150                155                160
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                 165                170                175
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
             180                185                190
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
         195                200                205
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
     210                215                220
Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
 225                230                235                240
Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                 245                250                255
Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
             260                265                270
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
         275                280                285
Gln Asp Leu Gly Pro Val Pro Met 
     290                295



<210> 9330
<211> 1150
<212> DNA
<213> Rattus norvegicus
<308> X13044
<400> 9330

gcagcagca  cagcaccag  agcacttgg  ggaaaagct  gaggctaga  tcatggatg  60
ccagcgcga  ctcatctct  accatgagc  gctgcccat  ctgggccag  gtgctagag  120
cccagaaag  aattgcaac  gtggagtcc  gtacaccag  gtctctgtc  tggtggctc  180
gctcttggc  gggcaggcc  ccactgctt  cttcctgta  cagcagcag  gccgcctgg  240
caagctgac  gtcacctcc  agaacctgc  actggagaa  cttcgcatg  agcttccga  300
atctgccaa  cctgtgagc  cgatgcgca  ggctactcc  ttgctgatg  gcccactgt  360
catggataa  atgctccaa  cgcccgtga  gaatgttac  aagtatggc  acatgaccc  420
ggaccacgt  atgcacctg  ttacgaagt  tggacccgt  aactaccca  agctgaagg  480
gagcttccc  gagaatctg  agcacctta  gaactctat  aatggtctg  actggaagg  540
ctttgagag  tggatgaaa  agtggctgt  gtttgaaat  agcaagaac  ccctggagg  600
gaagcagcc  acccagact  cacctaaag  gccactgga  atggaagac  catcttctg  660
cctgggagt  accaagcag  atatgggcc  aatgttctt  tgaagacag  agccagctc  720
gcacggcgg  acgtcccct  ctcctcagc  cttcttaca  tccctaaca  cacacccat  780
ccgtcttcc  gcacctggg  ttgagactg  tatctgctt  accgtccct  acacaacaa  840
tgaaaccgg  acagaatga  aacactgga  ggagggcct  gctgcctac  cccatctaa  900
ggaccccca  ttctgaccc  ttagcagtc  ttaatgtgg  gctctgaga  ctaggccca  960
tgacaggga  aggggatgc  ctaccctta  tctaggctg  atacatttg  tgtcttctc  1020
aggaagagg  caagccctc  cagcaaccc  tcctcatgt  ctgccgacg  ccctgggat  1080
cctgctcag  caagcttgt  agcagcctg  aggaccatg  ttcacgtga  aataaaagg  1140
agaaggtaaa  1150



<210> 9331
<211> 280
<212> PRT
<213> Rattus norvegicus
<308> P10247
<400> 9331

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
  1               5                  10                  15
Leu Gly Gln Arg Ala Arg Ala Pro Glu Ser Asn Cys Asn Arg Gly Val 
             20                  25                  30
Leu Tyr Thr Ser Val Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln 
         35                  40                  45
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
     50                  55                  60
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
 65                  70                  75                  80
Leu Pro Lys Ser Ala Lys Pro Val Ser Pro Met Arg Met Ala Thr Pro 
                 85                  90                  95
Leu Leu Met Arg Pro Leu Ser Met Asp Asn Met Leu Gln Ala Pro Val 
             100                105                110
Lys Asn Val Thr Lys Tyr Gly Asn Met Thr Gln Asp His Val Met His 
         115                120                125
Leu Leu Thr Lys Ser Gly Pro Val Asn Tyr Pro Gln Leu Lys Gly Ser 
     130                135                140
Phe Pro Glu Asn Leu Lys His Leu Lys Asn Ser Met Asn Gly Leu Asp 
 145                150                155                160
Trp Lys Val Phe Glu Ser Trp Met Lys Gln Trp Leu Leu Phe Glu Met 
                 165                170                175
Ser Lys Asn Ser Leu Glu Glu Lys Gln Pro Thr Gln Thr Pro Pro Lys 
             180                185                190
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Asp Val His 
         195                200                205
Pro Gly Ala Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Met Pro 
     210                215                220
Leu Gln Cys His Gly Ser Thr Gly Tyr Cys Trp Cys Val Phe Pro Asn 
 225                230                235                240
Gly Thr Glu Val Pro His Thr Lys Ser Arg Gly Arg His Asn Cys Ser 
                 245                250                255
Glu Pro Leu Asp Met Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
             260                265                270
Gln Asp Met Gly Gln Met Phe Leu 
         275                280



<210> 9332
<211> 1304
<212> DNA
<213> Homo sapiens
<308> NM_004355
<400> 9332

ttcccagat  cacaggagg  gaagcagga  ctgtcggga  gatcagaag  cagtcatgg  60
tgaccagcg  gaccttatc  ccaacaatg  gcaactgcc  atgctgggc  ggcgccctg  120
ggccccgga  agcaagtgc  gccgcggag  cctgtacac  ggcttttcc  tcctggtga  180
tctgctcct  gctggccag  ccaccaccg  ctacttcct  taccagcag  agggccggc  240
ggacaaact  acagtcacc  cccagaacc  gcagctgga  aacctgcgc  tgaagcttc  300
caagcctcc  aagcctgtg  gcaagatgc  catggccac  ccgctgctg  tgcaggcgc  360
gcccatggg  gccctgccc  aggggccca  gcagaatgc  accaagtat  gcaacatga  420
agaggacca  gtgatgcac  tgctccaga  tgctgaccc  ctgaaggtg  acccgccac  480
gaaggggag  ttcccggag  acctgagac  ccttaagaa  accatggag  ccatagact  540
gaaggtctt  gagagctgg  tgcaccatt  gctcctgtt  gaaatgagc  ggcactcct  600
ggagcaaaa  cccactgac  ctccaccga  agagtcact  gaactggag  acccgtctt  660
tgggctggg  gtgaccaag  aggatctgg  cccagtccc  atgtgagag  agcagaggc  720
gtcttcaac  tcctgccag  cccacacag  tacagcttt  ttgctccct  cagccccca  780
cccctcccc  atgtcccac  ctgtacctc  tcccatgag  cctggtgcc  ggctctttc  840
tcacccttg  acaagacaa  ccaagtcgg  acagcagat  acaatgcag  aaggccctg  900
tgcccaatc  ccatctgtc  acaggggcg  gaggtccca  gaagtggcc  aaagctaga  960
agatccccg  tcctgacat  acagcagcc  ccaacacaa  gctccaaga  ctaggctca  1020
ggacgagat  ggaaggcac  gggagaagg  ataacccta  acccagacc  caggctgga  1080
atgctgact  tcctctccc  tccagcctt  ggccttggc  tttctagcc  atttacctg  1140
aggctgagc  actctcttc  ctttcccca  catcactcc  caaggaaga  ccaatgttt  1200
ggacccata  tcctttctg  cgaccccta  ttccctctg  tcagccaag  ttgttatca  1260
ctttcaggg  catggttca  attagaata  aaggtagta  ttag  1304



<210> 9333
<211> 296
<212> PRT
<213> Homo sapiens
<308> P04233
<400> 9333

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
  1               5                  10                  15
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
             20                  25                  30
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
         35                  40                  45
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
     50                  55                  60
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
 65                  70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                 85                  90                  95
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
             100                105                110
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
         115                120                125
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
     130                135                140
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
 145                150                155                160
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                 165                170                175
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
             180                185                190
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
         195                200                205
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
     210                215                220
Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
 225                230                235                240
Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                 245                250                255
Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
             260                265                270
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
         275                280                285
Gln Asp Leu Gly Pro Val Pro Met 
     290                295



<210> 9334
<211> 1150
<212> DNA
<213> Rattus norvegicus
<308> X13044
<400> 9334

gcagcagca  cagcaccag  agcacttgg  ggaaaagct  gaggctaga  tcatggatg  60
ccagcgcga  ctcatctct  accatgagc  gctgcccat  ctgggccag  gtgctagag  120
cccagaaag  aattgcaac  gtggagtcc  gtacaccag  gtctctgtc  tggtggctc  180
gctcttggc  gggcaggcc  ccactgctt  cttcctgta  cagcagcag  gccgcctgg  240
caagctgac  gtcacctcc  agaacctgc  actggagaa  cttcgcatg  agcttccga  300
atctgccaa  cctgtgagc  cgatgcgca  ggctactcc  ttgctgatg  gcccactgt  360
catggataa  atgctccaa  cgcccgtga  gaatgttac  aagtatggc  acatgaccc  420
ggaccacgt  atgcacctg  ttacgaagt  tggacccgt  aactaccca  agctgaagg  480
gagcttccc  gagaatctg  agcacctta  gaactctat  aatggtctg  actggaagg  540
ctttgagag  tggatgaaa  agtggctgt  gtttgaaat  agcaagaac  ccctggagg  600
gaagcagcc  acccagact  cacctaaag  gccactgga  atggaagac  catcttctg  660
cctgggagt  accaagcag  atatgggcc  aatgttctt  tgaagacag  agccagctc  720
gcacggcgg  acgtcccct  ctcctcagc  cttcttaca  tccctaaca  cacacccat  780
ccgtcttcc  gcacctggg  ttgagactg  tatctgctt  accgtccct  acacaacaa  840
tgaaaccgg  acagaatga  aacactgga  ggagggcct  gctgcctac  cccatctaa  900
ggaccccca  ttctgaccc  ttagcagtc  ttaatgtgg  gctctgaga  ctaggccca  960
tgacaggga  aggggatgc  ctaccctta  tctaggctg  atacatttg  tgtcttctc  1020
aggaagagg  caagccctc  cagcaaccc  tcctcatgt  ctgccgacg  ccctgggat  1080
cctgctcag  caagcttgt  agcagcctg  aggaccatg  ttcacgtga  aataaaagg  1140
agaaggtaaa  1150



<210> 9335
<211> 280
<212> PRT
<213> Rattus norvegicus
<308> P10247
<400> 9335

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
  1               5                  10                  15
Leu Gly Gln Arg Ala Arg Ala Pro Glu Ser Asn Cys Asn Arg Gly Val 
             20                  25                  30
Leu Tyr Thr Ser Val Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln 
         35                  40                  45
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
     50                  55                  60
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
 65                  70                  75                  80
Leu Pro Lys Ser Ala Lys Pro Val Ser Pro Met Arg Met Ala Thr Pro 
                 85                  90                  95
Leu Leu Met Arg Pro Leu Ser Met Asp Asn Met Leu Gln Ala Pro Val 
             100                105                110
Lys Asn Val Thr Lys Tyr Gly Asn Met Thr Gln Asp His Val Met His 
         115                120                125
Leu Leu Thr Lys Ser Gly Pro Val Asn Tyr Pro Gln Leu Lys Gly Ser 
     130                135                140
Phe Pro Glu Asn Leu Lys His Leu Lys Asn Ser Met Asn Gly Leu Asp 
 145                150                155                160
Trp Lys Val Phe Glu Ser Trp Met Lys Gln Trp Leu Leu Phe Glu Met 
                 165                170                175
Ser Lys Asn Ser Leu Glu Glu Lys Gln Pro Thr Gln Thr Pro Pro Lys 
             180                185                190
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Asp Val His 
         195                200                205
Pro Gly Ala Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Met Pro 
     210                215                220
Leu Gln Cys His Gly Ser Thr Gly Tyr Cys Trp Cys Val Phe Pro Asn 
 225                230                235                240
Gly Thr Glu Val Pro His Thr Lys Ser Arg Gly Arg His Asn Cys Ser 
                 245                250                255
Glu Pro Leu Asp Met Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
             260                265                270
Gln Asp Met Gly Gln Met Phe Leu 
         275                280



<210> 9336
<211> 1304
<212> DNA
<213> Homo sapiens
<308> NM_004355
<400> 9336

ttcccagat  cacaggagg  gaagcagga  ctgtcggga  gatcagaag  cagtcatgg  60
tgaccagcg  gaccttatc  ccaacaatg  gcaactgcc  atgctgggc  ggcgccctg  120
ggccccgga  agcaagtgc  gccgcggag  cctgtacac  ggcttttcc  tcctggtga  180
tctgctcct  gctggccag  ccaccaccg  ctacttcct  taccagcag  agggccggc  240
ggacaaact  acagtcacc  cccagaacc  gcagctgga  aacctgcgc  tgaagcttc  300
caagcctcc  aagcctgtg  gcaagatgc  catggccac  ccgctgctg  tgcaggcgc  360
gcccatggg  gccctgccc  aggggccca  gcagaatgc  accaagtat  gcaacatga  420
agaggacca  gtgatgcac  tgctccaga  tgctgaccc  ctgaaggtg  acccgccac  480
gaaggggag  ttcccggag  acctgagac  ccttaagaa  accatggag  ccatagact  540
gaaggtctt  gagagctgg  tgcaccatt  gctcctgtt  gaaatgagc  ggcactcct  600
ggagcaaaa  cccactgac  ctccaccga  agagtcact  gaactggag  acccgtctt  660
tgggctggg  gtgaccaag  aggatctgg  cccagtccc  atgtgagag  agcagaggc  720
gtcttcaac  tcctgccag  cccacacag  tacagcttt  ttgctccct  cagccccca  780
cccctcccc  atgtcccac  ctgtacctc  tcccatgag  cctggtgcc  ggctctttc  840
tcacccttg  acaagacaa  ccaagtcgg  acagcagat  acaatgcag  aaggccctg  900
tgcccaatc  ccatctgtc  acaggggcg  gaggtccca  gaagtggcc  aaagctaga  960
agatccccg  tcctgacat  acagcagcc  ccaacacaa  gctccaaga  ctaggctca  1020
ggacgagat  ggaaggcac  gggagaagg  ataacccta  acccagacc  caggctgga  1080
atgctgact  tcctctccc  tccagcctt  ggccttggc  tttctagcc  atttacctg  1140
aggctgagc  actctcttc  ctttcccca  catcactcc  caaggaaga  ccaatgttt  1200
ggacccata  tcctttctg  cgaccccta  ttccctctg  tcagccaag  ttgttatca  1260
ctttcaggg  catggttca  attagaata  aaggtagta  ttag  1304



<210> 9337
<211> 296
<212> PRT
<213> Homo sapiens
<308> P04233
<400> 9337

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
  1               5                  10                  15
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
             20                  25                  30
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
         35                  40                  45
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
     50                  55                  60
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
 65                  70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                 85                  90                  95
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
             100                105                110
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
         115                120                125
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
     130                135                140
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
 145                150                155                160
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                 165                170                175
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
             180                185                190
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
         195                200                205
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
     210                215                220
Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
 225                230                235                240
Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                 245                250                255
Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
             260                265                270
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
         275                280                285
Gln Asp Leu Gly Pro Val Pro Met 
     290                295



<210> 9338
<211> 1509
<212> DNA
<213> Rattus norvegicus
<308> X13411
<400> 9338

gaagctgtc  gggagtttg  caaggagat  gatgtgtct  ttgtgaaaa  tgaagaggt  60
atcggagca  gggagtttg  agaagtgta  aagggccga  tgaagctgc  aggcaagag  120
gaaatctat  tggccatca  gaccctgaa  gctgggtac  cagagaaac  gcgtcggga  180
tttctgagc  aggcgagca  catgggcca  tttgaccat  ccaacatca  tcgcctaga  240
ggtgttgtc  ccaagagcc  acctgtcat  atcattacg  agttcatgg  gaatggcgc  300
ttagactct  tcctccggc  aaatgacgg  cagttcacc  tgatccagc  tgtggggat  360
ctgaggggc  tcgctgctg  catgaagta  ctatctgag  tgaattatg  gcaccggga  420
ctggctgct  ggaacattc  ggtgaacag  aacctggtg  gcaaagtgt  tgactttgg  480
ctctctcgc  acctccagg  tgacacctc  gaccccacc  acaccagct  cttgggggg  540
aagatacct  ttagatgga  agctccaga  gccatcgcc  accgcaagt  tacgtcagc  600
agcgatgtc  ggagctacg  gattgtcat  tgggaagta  tgtcatttg  agagagacc  660
tactgggat  tgtccaatc  agatgtcat  aatgccatt  agcaggact  ccggctgcc  720
cctcctatg  actgcccag  tgccctgca  cagctcatg  tggactgtt  gcagaagga  780
cgaaatagc  ggccccgtt  tgcagagat  gtcaacacc  tggacaaga  gatccggaa  840
ccagctagt  tcaagactg  ggcaaccat  accgctgtg  cttcccaac  cctgcttga  900
cgctctatc  cagacttca  ggcctttac  accgtggat  actggctaa  tgccatcaa  960
atggtccag  acagggaca  cttcctcac  gctggcttc  cctccctcc  gctggtcac  1020
cagatgaca  cagaagacc  cctgagaat  ggggtcacc  tggcaggcc  tcagaagaa  1080
attcttagc  gcatccact  gatgagggt  cagatgaac  agtcaccgt  ggtaatggc  1140
tgagaactc  atgttccta  gggaggaga  gaatgaaaa  gaccagggt  aaaggggaa  1200
cagaggttg  ccacggtgg  atgtgccag  aagatcagc  tcttggctg  gaaacaact  1260
cccacctgt  aagaatgaa  tggacctgc  gcccatggg  aaccgccat  tctcggcca  1320
ggaagtgtg  agaagccgt  ggaaaccaa  cgcgtaatg  ttgacgata  agacagaga  1380
aggtgatgc  aaacagaag  gaagctgaa  ccgtatgcg  tgggaacca  ggtgaactc  1440
gttcccatc  gagagggac  ggagttccc  gtctgcagg  agaaaggaa  gaggtggag  1500
gaagagagg  1509



<210> 9339
<211> 984
<212> PRT
<213> Rattus norvegicus
<308> CAA31777
<400> 9339

Met Ala Leu Asp Cys Leu Leu Leu Phe Leu Leu Ala Ser Ala Val Ala 
  1               5                  10                  15
Ala Met Glu Glu Thr Leu Met Asp Thr Arg Thr Ala Thr Ala Glu Leu 
             20                  25                  30
Gly Trp Thr Ala Asn Pro Ala Ser Gly Trp Glu Glu Val Ser Gly Tyr 
         35                  40                  45
Asp Glu Asn Leu Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val Phe 
     50                  55                  60
Glu Pro Asn Gln Asn Asn Trp Leu Leu Thr Thr Phe Ile Asn Arg Arg 
 65                  70                  75                  80
Gly Ala His Arg Ile Tyr Thr Glu Met Arg Phe Thr Val Arg Asp Cys 
                 85                  90                  95
Ser Ser Leu Pro Asn Val Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu 
             100                105                110
Tyr Tyr Tyr Glu Thr Asp Ser Val Ile Ala Thr Lys Lys Ser Ala Phe 
         115                120                125
Trp Ser Glu Ala Pro Tyr Leu Lys Val Asp Thr Ile Ala Ala Asp Glu 
     130                135                140
Ser Phe Ser Gln Val Asp Phe Gly Gly Arg Leu Met Lys Val Asn Thr 
 145                150                155                160
Glu Val Arg Ser Phe Gly Pro Leu Thr Arg Asn Gly Phe Tyr Leu Ala 
                 165                170                175
Phe Gln Asp Tyr Gly Ala Cys Met Ser Leu Leu Ser Val Arg Val Phe 
             180                185                190
Phe Lys Lys Cys Pro Ser Ile Val Gln Asn Phe Ala Val Phe Pro Glu 
         195                200                205
Thr Met Thr Gly Ala Glu Ser Thr Ser Leu Val Ile Ala Arg Gly Thr 
     210                215                220
Cys Ile Pro Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr Cys 
 225                230                235                240
Asn Gly Asp Gly Glu Trp Met Val Pro Ile Gly Arg Cys Thr Cys Lys 
                 245                250                255
Ala Gly Tyr Glu Pro Glu Asn Ser Val Ala Cys Lys Ala Cys Pro Ala 
             260                265                270
Gly Thr Phe Lys Ala Ser Gln Glu Ala Glu Gly Cys Ser His Cys Pro 
         275                280                285
Ser Asn Ser Arg Ser Pro Ser Glu Ala Ser Pro Ile Cys Thr Cys Arg 
     290                295                300
Thr Gly Tyr Tyr Arg Ala Asp Phe Asp Pro Pro Glu Val Ala Cys Thr 
 305                310                315                320
Ser Val Pro Ser Gly Pro Arg Asn Val Ile Ser Ile Val Asn Glu Thr 
                 325                330                335
Ser Ile Ile Leu Glu Trp His Pro Pro Arg Glu Thr Gly Gly Arg Asp 
             340                345                350
Asp Val Thr Tyr Asn Ile Ile Cys Lys Lys Cys Arg Ala Asp Arg Arg 
         355                360                365
Ser Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro Arg Gln Leu 
     370                375                380
Gly Leu Thr Glu Cys Arg Val Ser Ile Ser Ser Leu Trp Ala His Thr 
 385                390                395                400
Pro Tyr Thr Phe Asp Ile Gln Ala Ile Asn Gly Val Ser Ser Lys Ser 
                 405                410                415
Pro Phe Pro Pro Gln His Val Ser Val Asn Ile Thr Thr Asn Gln Ala 
             420                425                430
Ala Pro Ser Thr Val Pro Ile Met His Gln Val Ser Ala Thr Met Arg 
         435                440                445
Ser Ile Thr Leu Ser Trp Pro Gln Pro Glu Gln Pro Asn Gly Ile Ile 
     450                455                460
Leu Asp Tyr Glu Ile Arg Tyr Tyr Glu Lys Glu His Asn Glu Phe Asn 
 465                470                475                480
Ser Ser Met Ala Arg Ser Gln Thr Asn Thr Ala Arg Ile Asp Gly Leu 
                 485                490                495
Arg Pro Gly Met Val Tyr Val Val Gln Val Arg Ala Arg Thr Val Ala 
             500                505                510
Gly Tyr Gly Lys Phe Ser Gly Lys Met Cys Phe Gln Thr Leu Thr Asp 
         515                520                525
Asp Asp Tyr Lys Ser Glu Leu Arg Glu Gln Leu Pro Leu Ile Ala Gly 
     530                535                540
Ser Ala Ala Ala Gly Val Val Phe Val Val Ser Leu Val Ala Ile Ser 
 545                550                555                560
Ile Val Cys Ser Arg Lys Arg Ala Tyr Ser Lys Glu Ala Val Tyr Ser 
                 565                570                575
Asp Lys Leu Gln His Tyr Ser Thr Gly Arg Gly Ser Pro Gly Met Lys 
             580                585                590
Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg 
         595                600                605
Glu Phe Ala Lys Glu Ile Asp Val Ser Phe Val Lys Ile Glu Glu Val 
     610                615                620
Ile Gly Ala Gly Glu Phe Gly Glu Val Tyr Lys Gly Arg Leu Lys Leu 
 625                630                635                640
Pro Gly Lys Arg Glu Ile Tyr Val Ala Ile Lys Thr Leu Lys Ala Gly 
                 645                650                655
Tyr Ser Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met 
             660                665                670
Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr 
         675                680                685
Lys Ser Arg Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala 
     690                695                700
Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln 
 705                710                715                720
Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ser 
                 725                730                735
Glu Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val 
             740                745                750
Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr 
         755                760                765
Leu Gln Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly 
     770                775                780
Lys Ile Pro Val Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
 785                790                795                800
Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                 805                810                815
Val Met Ser Phe Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
             820                825                830
Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp 
         835                840                845
Cys Pro Ala Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
     850                855                860
Arg Asn Ser Arg Pro Arg Phe Ala Glu Ile Val Asn Thr Leu Asp Lys 
 865                870                875                880
Met Ile Arg Asn Pro Ala Ser Leu Lys Thr Val Ala Thr Ile Thr Ala 
                 885                890                895
Val Pro Ser Gln Pro Leu Leu Asp Arg Ser Ile Pro Asp Phe Thr Ala 
             900                905                910
Phe Thr Thr Val Asp Asp Trp Leu Ser Ala Ile Lys Met Val Gln Tyr 
         915                920                925
Arg Asp Ser Phe Leu Thr Ala Gly Phe Thr Ser Leu Gln Leu Val Thr 
     930                935                940
Gln Met Thr Ser Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly 
 945                950                955                960
His Gln Lys Lys Ile Leu Ser Ser Ile His Ser Met Arg Val Gln Met 
                 965                970                975
Asn Gln Ser Pro Ser Val Met Ala 
             980



<210> 9340
<211> 3037
<212> DNA
<213> Rattus norvegicus
<308> X13722
<400> 9340

ttgacccag  gcggcgtag  attgcagcc  gcatacctg  ggcttgcca  ccaggtttt  60
cagctgaga  accgtggga  ccgtgatcc  gtgtttgca  cgggaacat  tcgggtctg  120
gatccgagt  gggacgcga  gcagaggct  aggatgagc  ccgcggatc  gatgctacg  180
tgggccatc  ccctgctcc  ggctgctgc  ggagttgca  cagaagatt  atgtggcaa  240
aacgagttc  agtgtagag  cggaaaatg  atcgtcagc  agtgggtgt  tgacggcag  300
cgcgagtgc  cggatggct  cgatgagtc  cctgagaca  gcatgtctg  cacctgtcg  360
tccggtgag  tcagctgtg  aggccgcgt  agccgatgc  ttcctgact  ctggagatg  420
gatgggcgg  ccgactgtg  aaatggctc  gatgaacta  actgctccc  caagacgtg  480
tccctggat  agttccgct  ccaggatgg  aagtgcatc  cccggcagt  tgtgtgtga  540
caagactgg  attgcctgg  tggctctga  gaggcccac  gtgcggcca  cacttgtgg  600
cctgctcac  tccgctgca  ctcctcttc  tgcatcccc  gcctgtggg  ctgcgacgg  660
gaccgggac  gtgacgatg  ctccgatga  tggccgcag  actgcgggg  cgaagacac  720
gccgctgag  tggtcagca  cccctgctc  tccctcgag  tccactgtg  cagtagtga  780
tgtatccat  gcagctggg  ctgtgacgg  gcggctgac  gcaaggaca  gtcggacga  840
gagaactgc  cggtgacca  ctgccgacc  gacgaattc  agtgtgcag  tggctcctg  900
attcacggt  gccgccagt  tgaccgtga  catgactgc  aagacatga  cgacgagct  960
ggctgcatc  atgtgaccc  gtgcgatgg  cctaacaaa  tcaagtgcc  cagtgggga  1020
tgcatcagc  tggacaagg  gtgcaactc  gcccgggac  gtcgtgact  gtcggatga  1080
cccatcaag  agtgcaaga  caacgagtg  ttggacaac  atggtggct  ttcccacat  1140
tgcaaggac  tcaagattg  ctatgagtg  ctatgtccc  gcggtttcc  gttggtgga  1200
ggccaccag  gtgaagata  tgacgagtg  caggagcca  acacctgca  ccagctctg  1260
gtgaacctg  agggcagct  caagtgcga  tgtcgggcc  gcttccaca  ggaccctca  1320
accagggtc  gcaaggctg  gggttccat  gggtttctg  tcttcacca  ccgccatga  1380
gtacgtaag  tgaccctgg  ccgcagcga  tataccagc  tgatcccca  cctgaagaa  1440
gtggtggcg  tggacactg  ggtggccaa  aatagaatt  actggtctg  cctgtccca  1500
agaaagatc  acagcgccg  gatggacca  ggcaccagc  tgtcctatg  tgccatcat  1560
agtggggac  tgcacgccc  tgacgggct  gcggtagac  ggatccatg  caacatcta  1620
tggacggat  cagttccgg  cactgtttc  gtggctgac  ccaagggtg  caggaggag  1680
actctgttc  gagagaaag  gtccagacc  agagccatc  tagtggacc  tgtgcatgg  1740
ttcatgtac  ggacagatt  ggggacacc  gccaagatc  agaaagggg  tttgaatgg  1800
gtagacatc  actctctgg  gaccgagga  atccagtgg  caaatggca  cacactaga  1860
cttcccagt  gccgcctct  ttgggttga  tccaaactc  actccatct  cagcatcga  1920
gtcaatggg  gtggtcgga  aaccatttt  gaggatgag  agcagctag  tcacccctt  1980
tccttggcc  tctatgagg  caaagtgta  tggacagat  tcttaaatg  agccatttt  2040
agtgccaac  gcctcacgg  ttcagatgt  aatttggtg  ctaaaaacc  catgtcccc  2100
gaggacatt  tcctgtttc  caacgtcac  cagcctaga  gggtaaact  gtgtgaggc  2160
acggttctc  ccaacggtg  ctgccagta  atgtgcctg  ctgcccctc  gatcagtgc  2220
cactcaccc  agttcacct  cgcttgccc  gatggtatg  tactggcca  ggacatgag  2280
agctgcctc  cagaagtcg  cactgtacc  accacccag  ggacatcca  cattgggcc  2340
gtggtcacc  catcagctg  tgtgtcact  aagcgcaag  aggatccct  agctactag  2400
cacaaggag  atccctcag  tactaggca  aatgaggat  cctcagcta  cagcacctc  2460
aggcagcct  gggataccc  agagctcag  acagtggag  cggtgacag  gtcctccca  2520
gtccaaggt  acatggctg  cagagggga  gaggtgcag  ggcacggtg  ggggttctt  2580
tccatcttc  tccccattg  actggtggc  ctccttgtc  tcggagcca  cctcctgtg  2640
aggaactgg  ggctgagga  cattaacag  ataaacttt  acaacccag  ctaccagaa  2700
accacggag  acgagatcc  catttgccg  agccaggat  gctatacct  cccctcgag  2760
cagatggtc  gcctggagg  tgatgtggc  tgaacagct  aggggagcc  tctctttcc  2820
ggatccgct  ccaccctta  gcaggaagg  cgctttctc  cacctcccc  ccctgcact  2880
gtccttcca  ctcagtggt  tctgtgttg  tcaaagcaa  ataagagca  aactgggct  2940
gggccaagc  cagcggcct  tctgccctg  gtcctgttt  atatattta  tgtctgggg  3000
cagaaaagg  tactggcca  gctccagat  ggaattc  3037



<210> 9341
<211> 879
<212> PRT
<213> Rattus norvegicus
<308> P35952
<400> 9341

Met Ser Thr Ala Asp Leu Met Leu Arg Trp Ala Ile Ala Leu Leu Leu 
  1               5                  10                  15
Ala Ala Ala Gly Val Ala Ala Glu Asp Ser Cys Gly Lys Asn Glu Phe 
             20                  25                  30
Gln Cys Arg Asp Gly Lys Cys Ile Val Ser Lys Trp Val Cys Asp Gly 
         35                  40                  45
Ser Arg Glu Cys Pro Asp Gly Ser Asp Glu Ser Pro Glu Thr Cys Met 
     50                  55                  60
Ser Val Thr Cys Arg Ser Gly Glu Phe Ser Cys Gly Gly Arg Val Ser 
 65                  70                  75                  80
Arg Cys Ile Pro Asp Ser Trp Arg Cys Asp Gly Arg Thr Asp Cys Glu 
                 85                  90                  95
Asn Gly Ser Asp Glu Leu Asp Cys Ser Pro Lys Thr Cys Ser Leu Asp 
             100                105                110
Glu Phe Arg Cys Gln Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
         115                120                125
Asp Gln Asp Trp Asp Cys Leu Asp Gly Ser Asp Glu Ala His Cys Ala 
     130                135                140
Ala Thr Thr Cys Gly Pro Ala His Phe Arg Cys Asn Ser Ser Ser Cys 
 145                150                155                160
Ile Pro Ser Leu Trp Ala Cys Asp Gly Asp Arg Asp Cys Asp Asp Gly 
                 165                170                175
Ser Asp Glu Trp Pro Gln Asn Cys Gly Ala Glu Asp Thr Ala Ala Glu 
             180                185                190
Val Val Ser Ser Pro Cys Ser Ser Leu Glu Phe His Cys Gly Ser Ser 
         195                200                205
Glu Cys Ile His Arg Ser Trp Val Cys Asp Gly Ala Ala Asp Cys Lys 
     210                215                220
Asp Lys Ser Asp Glu Glu Asn Cys Ala Val Thr Thr Cys Arg Pro Asp 
 225                230                235                240
Glu Phe Gln Cys Ala Asp Gly Ser Cys Ile His Gly Ser Arg Gln Cys 
                 245                250                255
Asp Arg Glu His Asp Cys Lys Asp Met Ser Asp Glu Leu Gly Cys Ile 
             260                265                270
Asn Val Thr Gln Cys Asp Gly Pro Asn Lys Phe Lys Cys His Ser Gly 
         275                280                285
Glu Cys Ile Ser Leu Asp Lys Val Cys Asn Ser Ala Arg Asp Cys Arg 
     290                295                300
Asp Trp Ser Asp Glu Pro Ile Lys Glu Cys Lys Thr Asn Glu Cys Leu 
 305                310                315                320
Asp Asn Asn Gly Gly Cys Ser His Ile Cys Lys Asp Leu Lys Ile Gly 
                 325                330                335
Tyr Glu Cys Leu Cys Pro Ser Gly Phe Arg Leu Val Asp Gly His Gln 
             340                345                350
Cys Glu Asp Ile Asp Glu Cys Gln Glu Pro Asp Thr Cys Ser Gln Leu 
         355                360                365
Cys Val Asn Leu Glu Gly Ser Phe Lys Cys Glu Cys Arg Ala Gly Phe 
     370                375                380
His Met Asp Pro His Thr Arg Val Cys Lys Ala Val Gly Ser Ile Gly 
 385                390                395                400
Phe Leu Leu Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp 
                 405                410                415
Arg Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Lys Asn Val Val Ala 
             420                425                430
Leu Asp Thr Glu Val Ala Asn Asn Arg Ile Tyr Trp Ser Asp Leu Ser 
         435                440                445
Gln Arg Lys Ile Tyr Ser Ala Val Met Asp Gln Gly Thr Ser Leu Ser 
     450                455                460
Tyr Asp Ala Ile Ile Ser Gly Asp Leu His Ala Pro Asp Gly Leu Ala 
 465                470                475                480
Val Asp Trp Ile His Gly Asn Ile Tyr Trp Thr Asp Ser Val Pro Gly 
                 485                490                495
Thr Val Ser Val Ala Asp Thr Lys Gly Val Arg Arg Arg Thr Leu Phe 
             500                505                510
Arg Glu Lys Gly Ser Arg Pro Arg Ala Ile Val Val Asp Pro Val His 
         515                520                525
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
     530                535                540
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asp Ile 
 545                550                555                560
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Pro Ser Gly Arg Leu Tyr 
                 565                570                575
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
             580                585                590
Gly Gly Arg Lys Thr Ile Leu Glu Asp Glu Lys Gln Leu Ala His Pro 
         595                600                605
Phe Ser Leu Ala Ile Tyr Glu Asp Lys Val Tyr Trp Thr Asp Val Leu 
     610                615                620
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
 625                630                635                640
Leu Val Ala Lys Asn Leu Met Ser Pro Glu Asp Ile Val Leu Phe His 
                 645                650                655
Asn Val Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Ala Thr Val Leu 
             660                665                670
Pro Asn Gly Gly Cys Gln Tyr Met Cys Leu Pro Ala Pro Gln Ile Ser 
         675                680                685
Ala His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
     690                695                700
Ala Lys Asp Met Arg Ser Cys Leu Pro Glu Val Asp Thr Val Pro Thr 
 705                710                715                720
Thr Gln Gly Thr Ser Thr Ile Gly Pro Val Val Thr Thr Ser Ala Ala 
                 725                730                735
Val Ser Leu Lys Arg Lys Glu Asp Pro Ser Ala Thr Arg His Lys Glu 
             740                745                750
Asp Pro Ser Ala Thr Arg His Asn Glu Asp Pro Ser Ala Thr Ser Thr 
         755                760                765
Ser Arg Gln Pro Gly Asp Thr Pro Glu Leu Ser Thr Val Glu Ser Val 
     770                775                780
Thr Val Ser Ser Gln Val Gln Gly Asp Met Ala Gly Arg Gly Asp Glu 
 785                790                795                800
Val Gln Arg His Gly Val Gly Phe Leu Ser Ile Phe Leu Pro Ile Ala 
                 805                810                815
Leu Val Ala Leu Leu Val Phe Gly Ala Ile Leu Leu Trp Arg Asn Trp 
             820                825                830
Arg Leu Arg Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln 
         835                840                845
Lys Thr Thr Glu Asp Glu Ile His Ile Cys Arg Ser Gln Asp Gly Tyr 
     850                855                860
Thr Tyr Pro Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
 865                870                875



<210> 9342
<211> 542
<212> DNA
<213> Homo sapiens
<308> S70123
<400> 9342

ctctgggcg  cgttgctgg  agaggaaat  agaagaagc  cagtagcgt  agggctctg  60
ccattgtcc  ccccatcgc  acggagctg  gtctctggt  tcgggggca  ctgtgtgac  120
gagcgtgcc  ctccctacg  tgctcctcg  cttcctttg  ctgggggtc  tccttctat  180
gaagaactg  cggcttaag  acatcaaca  catcaactt  gacaacccc  tctatcaga  240
gaccacaga  gatgaggtc  acatttgcc  caaccagga  ggctacagc  acccctcga  300
acagatggt  agtctggag  atgacgtgg  gtgaacatc  gcctggagt  ccgcccctg  360
ccagaaccc  tcctgagac  tcgccggcc  tgttttatt  aaagacaga  aagaccaaa  420
cattgcctg  cagagcttt  ttttatata  ttattcatc  gggaggcag  acaggcttc  480
gacagtgcc  atgcaatgg  ttgggttgg  attttggtt  cttcctttc  tgtgaagga  540
aa  542



<210> 9343
<211> 837
<212> PRT
<213> Homo sapiens
<308> AAF24515
<400> 9343

Gly Asp Arg Cys Glu Arg Asn Glu Phe Gln Cys Gln Asp Gly Lys Cys 
  1               5                  10                  15
Ile Ser Tyr Lys Trp Val Cys Asp Gly Ser Ala Glu Cys Gln Asp Gly 
             20                  25                  30
Ser Asp Glu Ser Gln Glu Thr Cys Leu Ser Val Thr Cys Lys Ser Gly 
         35                  40                  45
Asp Phe Ser Cys Gly Gly Arg Val Asn Arg Cys Ile Pro Gln Phe Trp 
     50                  55                  60
Arg Cys Asp Gly Gln Val Asp Cys Asp Asn Gly Ser Asp Glu Gln Gly 
 65                  70                  75                  80
Cys Pro Pro Lys Thr Cys Ser Gln Asp Glu Phe Arg Cys His Asp Gly 
                 85                  90                  95
Lys Cys Ile Ser Arg Gln Phe Val Cys Asp Ser Asp Arg Asp Cys Leu 
             100                105                110
Asp Gly Ser Asp Glu Ala Ser Cys Pro Val Leu Thr Cys Gly Pro Ala 
         115                120                125
Ser Phe Gln Cys Asn Ser Ser Thr Cys Ile Pro Gln Leu Trp Ala Cys 
     130                135                140
Asp Asn Asp Pro Asp Cys Glu Asp Gly Ser Asp Glu Trp Pro Gln Arg 
 145                150                155                160
Cys Arg Gly Leu Tyr Val Phe Gln Gly Asp Ser Ser Pro Cys Ser Ala 
                 165                170                175
Phe Glu Phe His Cys Leu Ser Gly Glu Cys Ile His Ser Ser Trp Arg 
             180                185                190
Cys Asp Gly Gly Pro Asp Cys Lys Asp Lys Ser Asp Glu Glu Asn Cys 
         195                200                205
Ala Val Ala Thr Cys Arg Pro Asp Glu Phe Gln Cys Ser Asp Gly Asn 
     210                215                220
Cys Ile His Gly Ser Arg Gln Cys Asp Arg Glu Tyr Asp Cys Lys Asp 
 225                230                235                240
Met Ser Asp Glu Val Gly Cys Val Asn Val Thr Leu Cys Glu Gly Pro 
                 245                250                255
Asn Lys Phe Lys Cys His Ser Gly Glu Cys Ile Thr Leu Asp Lys Val 
             260                265                270
Cys Asn Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro Ile Lys 
         275                280                285
Glu Cys Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His 
     290                295                300
Val Cys Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly 
 305                310                315                320
Phe Gln Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu Cys Gln 
                 325                330                335
Asp Pro Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Gly Tyr 
             340                345                350
Lys Cys Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Ala 
         355                360                365
Cys Lys Ala Val Gly Ser Ile Ala Tyr Leu Phe Phe Thr Asn Arg His 
     370                375                380
Glu Val Arg Lys Met Thr Leu Asp Arg Ser Glu Tyr Thr Ser Leu Ile 
 385                390                395                400
Pro Asn Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn 
                 405                410                415
Arg Ile Tyr Trp Ser Asp Leu Ser Gln Arg Met Ile Cys Ser Thr Gln 
             420                425                430
Leu Asp Arg Ala His Gly Val Ser Ser Tyr Asp Thr Val Ile Ser Arg 
         435                440                445
Asp Ile Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His Ser Asn 
     450                455                460
Ile Tyr Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala Asp Thr 
 465                470                475                480
Lys Gly Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys Pro 
                 485                490                495
Arg Ala Ile Val Val Asp Pro Val His Gly Phe Met Tyr Trp Thr Asp 
             500                505                510
Trp Gly Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly Val Asp 
         515                520                525
Ile Tyr Ser Leu Val Thr Glu Asn Ile Gln Trp Pro Asn Gly Ile Thr 
     530                535                540
Leu Asp Leu Leu Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys Leu His 
 545                550                555                560
Ser Ile Ser Ser Ile Asp Val Asn Gly Gly Asn Arg Lys Thr Ile Leu 
                 565                570                575
Glu Asp Glu Lys Arg Leu Ala His Pro Phe Ser Leu Ala Val Phe Glu 
             580                585                590
Asp Lys Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe Ser Ala 
         595                600                605
Asn Arg Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu Asn Leu Leu 
     610                615                620
Ser Pro Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro Arg Gly 
 625                630                635                640
Val Asn Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys Gln Tyr 
                 645                650                655
Leu Cys Leu Pro Ala Ser Gln Ile Asn Pro His Ser Pro Lys Phe Thr 
             660                665                670
Cys Ala Cys Pro Asp Gly Met Leu Leu Ala Arg Asp Met Arg Ser Cys 
         675                680                685
Leu Thr Glu Ala Glu Ala Ala Val Ala Thr Gln Glu Thr Ser Thr Val 
     690                695                700
Arg Leu Lys Val Ser Ser Thr Ala Val Arg Thr Gln His Thr Thr Thr 
 705                710                715                720
Arg Pro Val Pro Asp Thr Ser Arg Leu Pro Gly Ala Thr Pro Gly Leu 
                 725                730                735
Thr Thr Val Glu Ile Val Thr Met Ser His Gln Ala Leu Gly Asp Val 
             740                745                750
Ala Gly Arg Gly Asn Glu Lys Lys Pro Ser Ser Val Arg Ala Leu Ser 
         755                760                765
Ile Val Leu Pro Ile Val Leu Leu Val Phe Leu Cys Leu Gly Val Phe 
     770                775                780
Leu Leu Trp Lys Asn Trp Arg Leu Lys Asn Ile Asn Ser Ile Asn Phe 
 785                790                795                800
Asp Asn Pro Val Tyr Gln Lys Thr Thr Glu Asp Glu Val His Ile Cys 
                 805                810                815
His Asn Gln Asp Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val Ser Leu 
             820                825                830
Glu Asp Asp Val Ala 
         835



<210> 9344
<211> 3085
<212> DNA
<213> Rattus norvegicus
<308> X13804
<400> 9344

caccaggag  aggtgggcg  gctgctcgg  cagattcag  gctgcggtg  cgcgcaggc  60
caggctcag  ccgaggctc  ggacgccct  aagtgcgac  tgacgtcgg  gctgcggga  120
atccgcgcg  agctcgaag  acacacggt  cagagtacg  tgcagtcag  ggagtggtt  180
cgagtgaga  tggaccgac  ctcagaggc  gccaaagtg  acacggatg  tatgcgctc  240
gcccaagag  agataactg  gtaccggcg  cagctgcag  ccaggacca  agagttgga  300
gcactgaaa  gcaccaagg  gtcactgga  aggcagcgc  ctgagctgg  ggaccgtca  360
caggtagac  tggcctcct  ccaggatgc  attcagcag  tggacaatg  gctgagaaa  420
accaaatgg  agatggccg  gcagctccg  gagtaccag  acctgctca  cgtcaagat  480
gccctggat  ttgagatcg  tgcttacag  aaactcctg  aaggcgaag  gtgtcggat  540
ggctttgga  ccattccct  ctctcttac  gagggactc  caaaaattc  ctccatgtc  600
actcacata  aagtcaaaa  cgaagagaa  ataaaagta  tagaaaaat  ggagaagga  660
accgtcatt  tagaggaac  gacagaaga  atccaggtg  cagaagaag  gacagaaga  720
gaggacaaa  aggcccaag  ggaggaaga  gaagaggca  aagagggag  agaagaagc  780
gcaactacg  ctccccctg  agaagaggc  gcatctcca  aaaaggaaa  caagtctcc  840
gtgaaagaa  aggccaagt  cccagctga  gccaagtcc  cagctgagg  caagtcacc  900
gctgaggcc  agtccccag  tgaggtcaa  tctccagct  tggccaagt  cccagctga  960
gtcaaatct  cagctgagg  caaatctcc  gctgaggcc  agtcaccag  tgaggccaa  1020
tcaccagct  aggtcaact  tccagctac  gtgaagtct  caggtgagg  caagtcccc  1080
gctgaggcc  agtcaccag  tgaggtcaa  tctccagtg  aggccaagt  accagctga  1140
gccaagtct  cagcttcag  gaagtcccc  ggtgaggcc  agtcaccag  tgaggccaa  1200
tcaccagct  aggtcaagt  tccagctac  gtgaagtcc  cagttgagg  caagtcacc  1260
gctgaggtc  aatctccag  tacagtgaa  tccccagct  aggccaagt  accagttga  1320
gtcaaatct  cagcttcgg  gaagtcccc  agtgaagcc  agtcacctg  tggagccaa  1380
tcaccagct  aggccaagt  accagttgt  gccaaatca  cagctgagg  caagtcacc  1440
gctggagcc  agcctccag  tgaggccaa  tcaccagct  aggccaagt  tccagctga  1500
gccaagtct  cagctgagg  caagtcacc  gctgaggcc  agtcacctg  tgaggtaaa  1560
tctccagag  aggccaaga  ccccgtgaa  gaaggtgca  aatccctag  tgaggccaa  1620
tcccctgag  aggccaagt  ccctgtgaa  gaagagatc  agcctccag  tgaggtgaa  1680
tcccccgag  aggccaaga  ccccatgag  aaggaggcc  agtctcctg  gaaggccaa  1740
actctggat  tgaagtctc  agaagccaa  cctccagcg  aggaggaag  aaagcgccc  1800
gcagacatc  gatcccctg  gcaggtcaa  agtcctgcc  aggaggagg  caagtcccc  1860
gagaaggaa  agaccagga  tgaaaaggt  gctcccaag  aggaagagg  gaagtcccc  1920
gtggaggag  taaaagcca  agaaccccc  aagaaggtg  aggaggaga  gacaccagc  1980
acaccaaag  cagaggtga  ggagagcaa  aaagatgaa  ctcccaagg  ggcccagaa  2040
cccaaggcg  aggagaagg  gcctctcac  gaaaagccc  aggactctc  gggggaagc  2100
aagaaggaa  aggctaaag  gaagaaggc  gcggcccca  aggaggaga  gcccgccaa  2160
ttgggcgtg  aggaagagg  taaacccaa  gagaaggca  aagacgcca  ggccaaaga  2220
cctagcaaa  cctcagaga  ggagaaacc  aagaaggag  aggtgccgg  agcaccaga  2280
aagaaagac  ccaaggagg  gaagactac  gagtccaag  agcgtgagg  gaaacccaa  2340
atggagcca  ggccaagga  gaggacaag  gccttcccc  agagcctag  aaacccaag  2400
cagaaaagg  tgaaaagtc  tctagcaca  accaaaaag  cagccagcc  tcagagaag  2460
ccccagagg  caaggctgc  aagggagac  agtaagagg  cgagaggga  acccagaat  2520
gccaaagaa  ctcaggacg  ccccggtac  caagggttg  tgtaataaa  tttatttct  2580
cctttccct  cgtaagaag  aacaccact  agatggcgg  cccgccctc  ccaaacagg  2640
tttctatta  gattaagtt  gcaagagaa  atcaaccct  agccctgcc  ccccaacac  2700
aaagccctc  ccaaggtga  ggacaatta  gatagctta  cgtagccga  cggagatgt  2760
ttgctgaac  ctccacgta  aacgcgtga  taaaaactg  cccccctcc  ttccaagta  2820
gtgcattca  ttcccgtat  tcctaccga  aggtgaccg  agtaatgaa  gagcagtta  2880
aaatgcatt  tgcttgaaa  gttgtaacc  attcccgaa  gccttcttg  tttccaaag  2940
agcggtcag  cccttgccc  gtacacgct  ctggaagag  tgcagcagg  gaggcaggg  3000
gctggccgc  gaaccaggc  agggtgtgc  gtccactga  ggccacttt  gattgcttc  3060
gtgcaataa  acccaagtg  ttctg  3085



<210> 9345
<211> 831
<212> PRT
<213> Rattus norvegicus
<308> CAA32038
<400> 9345

His Gln Glu Glu Val Gly Glu Leu Leu Gly Gln Ile Gln Gly Cys Gly 
  1               5                  10                  15
Ala Ala Gln Ala Gln Ala Gln Ala Glu Ala Arg Asp Ala Leu Lys Cys 
             20                  25                  30
Asp Val Thr Ser Ala Leu Arg Glu Ile Arg Ala Gln Leu Glu Gly His 
         35                  40                  45
Thr Val Gln Ser Thr Leu Gln Ser Glu Glu Trp Phe Arg Val Arg Leu 
     50                  55                  60
Asp Arg Leu Ser Glu Ala Ala Lys Val Asn Thr Asp Ala Met Arg Ser 
 65                  70                  75                  80
Ala Gln Glu Glu Ile Thr Glu Tyr Arg Arg Gln Leu Gln Ala Arg Thr 
                 85                  90                  95
Thr Glu Leu Glu Ala Leu Lys Ser Thr Lys Glu Ser Leu Glu Arg Gln 
             100                105                110
Arg Ser Glu Leu Glu Asp Arg His Gln Val Asp Met Ala Ser Tyr Gln 
         115                120                125
Asp Ala Ile Gln Gln Leu Asp Asn Glu Leu Arg Asn Thr Lys Trp Glu 
     130                135                140
Met Ala Ala Gln Leu Arg Glu Tyr Gln Asp Leu Leu Asn Val Lys Met 
 145                150                155                160
Ala Leu Asp Leu Glu Ile Ala Ala Tyr Arg Lys Leu Leu Glu Gly Glu 
                 165                170                175
Glu Cys Arg Ile Gly Phe Gly Pro Ile Pro Phe Ser Leu Thr Glu Gly 
             180                185                190
Leu Pro Lys Ile Pro Ser Met Ser Thr His Ile Lys Val Lys Ser Glu 
         195                200                205
Glu Lys Ile Lys Val Val Glu Lys Ser Glu Lys Glu Thr Val Ile Val 
     210                215                220
Glu Glu Gln Thr Glu Glu Ile Gln Val Thr Glu Glu Val Thr Glu Glu 
 225                230                235                240
Glu Asp Lys Glu Ala Gln Gly Glu Glu Glu Glu Glu Ala Glu Glu Gly 
                 245                250                255
Gly Glu Glu Ala Ala Thr Thr Ser Pro Pro Ala Glu Glu Ala Ala Ser 
             260                265                270
Pro Glu Lys Glu Thr Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro 
         275                280                285
Ala Glu Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro Ala Glu Ala Lys 
     290                295                300
Ser Pro Ala Glu Val Lys Ser Pro Ala Val Ala Lys Ser Pro Ala Glu 
 305                310                315                320
Val Lys Ser Pro Ala Glu Val Lys Ser Pro Ala Glu Ala Lys Ser Pro 
                 325                330                335
Ala Glu Ala Lys Ser Pro Ala Glu Val Lys Ser Pro Ala Thr Val Lys 
             340                345                350
Ser Pro Gly Glu Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro Ala Glu 
         355                360                365
Val Lys Ser Pro Ala Glu Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro 
     370                375                380
Ala Ser Val Lys Ser Pro Gly Glu Ala Lys Ser Pro Ala Glu Ala Lys 
 385                390                395                400
Ser Pro Ala Glu Val Lys Ser Pro Ala Thr Val Lys Ser Pro Val Glu 
                 405                410                415
Ala Lys Ser Pro Ala Glu Val Lys Ser Pro Val Thr Val Lys Ser Pro 
             420                425                430
Ala Glu Ala Lys Ser Pro Val Glu Val Lys Ser Pro Ala Ser Val Lys 
         435                440                445
Ser Pro Ser Glu Ala Lys Ser Pro Ala Gly Ala Lys Ser Pro Ala Glu 
     450                455                460
Ala Lys Ser Pro Val Val Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro 
 465                470                475                480
Ala Gly Ala Lys Pro Pro Ala Glu Ala Lys Ser Pro Ala Glu Ala Lys 
                 485                490                495
Ser Pro Ala Glu Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro Ala Glu 
             500                505                510
Ala Lys Ser Pro Val Glu Val Lys Ser Pro Glu Lys Ala Lys Ser Pro 
         515                520                525
Val Lys Glu Gly Ala Lys Ser Leu Ala Glu Ala Lys Ser Pro Glu Lys 
     530                535                540
Ala Lys Ser Pro Val Lys Glu Glu Ile Lys Pro Pro Ala Glu Val Lys 
 545                550                555                560
Ser Pro Glu Lys Ala Lys Ser Pro Met Arg Lys Glu Ala Lys Ser Pro 
                 565                570                575
Glu Lys Ala Lys Thr Leu Asp Val Lys Ser Pro Glu Ala Lys Pro Pro 
             580                585                590
Ala Lys Glu Glu Ala Lys Arg Pro Ala Asp Ile Arg Ser Pro Glu Gln 
         595                600                605
Val Lys Ser Pro Ala Lys Glu Glu Ala Lys Ser Pro Glu Lys Glu Glu 
     610                615                620
Thr Arg Thr Glu Lys Val Ala Pro Lys Lys Glu Glu Val Lys Ser Pro 
 625                630                635                640
Val Glu Glu Val Lys Ala Lys Glu Pro Pro Lys Lys Val Glu Glu Glu 
                 645                650                655
Lys Thr Pro Ala Thr Pro Lys Thr Glu Val Lys Glu Ser Lys Lys Asp 
             660                665                670
Glu Ala Pro Lys Glu Ala Gln Lys Pro Lys Ala Glu Glu Lys Glu Pro 
         675                680                685
Leu Thr Glu Lys Pro Lys Asp Ser Pro Gly Glu Ala Lys Lys Glu Glu 
     690                695                700
Ala Lys Glu Lys Lys Ala Ala Ala Pro Glu Glu Glu Thr Pro Ala Lys 
 705                710                715                720
Leu Gly Val Lys Glu Glu Ala Lys Pro Lys Glu Lys Ala Glu Asp Ala 
                 725                730                735
Lys Ala Lys Glu Pro Ser Lys Pro Ser Glu Lys Glu Lys Pro Lys Lys 
             740                745                750
Glu Glu Val Pro Ala Ala Pro Glu Lys Lys Asp Thr Lys Glu Glu Lys 
         755                760                765
Thr Thr Glu Ser Lys Lys Arg Glu Glu Lys Pro Lys Met Glu Ala Lys 
     770                775                780
Ala Lys Glu Glu Asp Lys Gly Leu Pro Gln Glu Pro Ser Lys Pro Lys 
 785                790                795                800
Thr Glu Lys Ala Glu Lys Ser Ser Ser Thr Asp Gln Lys Asp Ser Gln 
                 805                810                815
Pro Ser Glu Lys Ala Pro Glu Asp Lys Ala Ala Lys Gly Asp Lys 
             820                825                830



<210> 9346
<211> 3750
<212> DNA
<213> Homo sapiens
<308> XM_037942
<400> 9346

atgatgagc  tcggcggcg  ggacgcgct  ctgggcgcc  cgttcgcgc  gctgcatgg  60
ggcggcagc  tccactacg  gctagcccg  aagggtggc  caggcggga  gcgctccgc  120
gctggctcc  ccagcggct  ccactcgtg  acacggacg  ccgtgagct  cgtgtccgc  180
tcgcccagc  gcttccgtg  cgcaggcgc  gcctcaagc  ccgactcgc  ggacacgct  240
agcaacggg  cggagggct  catggtggc  gtggccacc  cacgcagtg  gaaggagca  300
ctgcaggcg  tgaacgacc  cttcgccgg  tacatcgac  aggtgcggc  gctggaggc  360
cacaaccgc  gcctggagg  cgaggctgc  gcgctgcgg  agcagcagg  gggccgctc  420
gctatgggc  agctgtacg  gcgcgaggt  cgcgagatg  gcggcgcgg  gctgcgcct  480
ggcgcggcg  gcggtcagc  acgcctgga  caggagcac  tgctcgagg  catcgcgca  540
gtgcgccag  gcctagacg  cgaggcccg  cagcgagag  aggccgagg  ggcggcccg  600
gcgctggcg  gcttcgcgc  ggaggccga  gcggcgcgc  tggacctgc  gaagaaggc  660
caggcgctg  aggaggagt  cggctacct  cggcgccac  accaggaag  ggtgggcga  720
ctgctcggc  agatccagg  ctccggcgc  gcgcaggcg  agatgcagg  cgagacgcg  780
gacgccctg  agtgcgacg  gacgtcggc  ctgcgcgag  ttcgcgcgc  gcttgaagg  840
cacgcggtg  agagcacgc  gcagtccga  gagtggttc  gagtgaggc  ggaccgact  900
tcggaggca  ccaaggtga  cacagacgc  atgcgctca  cgcaggagg  gataactga  960
taccggcgt  agctgcagg  caggaccac  gagctggag  cactgaaaa  caccaagga  1020
tcactggag  ggcagcgct  tgagctgga  gaccgtcat  aggccgaca  tgcctccta  1080
caggaagcc  ttcagcagc  ggacgctga  ctgaggaac  ccaagtggg  gatggccgc  1140
cagctgcga  aataccagg  cctgctcaa  gtcaagatg  ctctggata  agagatagc  1200
gcttacaga  aactcctgg  aggtgaaga  tgtcggatt  gctttggcc  aattccttt  1260
tcgcttcca  aaggactcc  caaaattcc  tctgtgtcc  ctcacataa  ggtgaaaag  1320
gaagagaag  tcaaagtgg  ggagaagtc  gagaaagaa  ctgtgattg  ggaggaaca  1380
acagaggag  cccaagtga  tgaagaagt  actgaagaa  aggagaaag  ggccaaaga  1440
gaggagggc  aggaggaag  agggggtga  gaagaggag  cagaagggg  agaagaaga  1500
acaaagtct  ccccagcag  agaggctgc  tccccagag  aggaagcca  gtcaccagt  1560
aaggaagag  caaagtcac  ggctgaggc  aagtcccca  agaaggagg  agcaaaatc  1620
ccagccgaa  tcaagtccc  tgagaaggc  aagtctcca  caaaggaag  ggcaaagtc  1680
ccgcctgag  ccaagtccc  agagaagga  gaagcaaaa  ctccagctg  ggtcaagtc  1740
cccgagaag  ccaagtccc  agcaaagga  gaggcaaag  caccggctg  ggccaagtc  1800
ccagagaag  ccaagtccc  agtgaagga  gaagcaaag  caccggctg  ggccaagtc  1860
ccagtgaag  aagaagcaa  atctccagc  gaggtcaag  ccccggaaa  ggccaagtc  1920
ccaacgaag  aggaagcaa  gtcccctga  aaggccaag  ccccagaga  ggaagaggc  1980
aagtcccct  agaaggcca  gtccccagt  aaggcagaa  caaagtccc  tgagaaggc  2040
aagtcccca  tgaaggcag  agcaaagtc  cctgagaag  ccaagtccc  agtgaagga  2100
gaagcaaag  cccctgaga  ggccaagtc  ccagtgaag  aagaagcaa  gtcccctga  2160
aaggccaag  ccccagtga  ggaagaagc  aagaccccc  agaaggcca  gtccccagt  2220
aaggaagaa  ccaagtccc  agagaaggc  aagtcccca  agaaggcca  gactcttga  2280
gtgaagtct  cagaagcca  gactccagc  aaggaggaa  caaggtccc  tgcagacaa  2340
ttccctgaa  aggccaaaa  ccctgtcaa  gaggaggtc  agtccccag  gaaggcgaa  2400
tctcccctg  aggcggatg  caaggcccc  gagaaggag  tcccaaaaa  ggaagaggt  2460
aagtcccca  tgaaggagg  ggagaagcc  caggaggtg  aagtcaaag  gcccccaaa  2520
aaggcagag  aagagaaag  ccctgccac  ccaaaaaca  aggagaaga  ggacagcaa  2580
aaagaggag  cacccaaga  ggaggctcc  aagcccaag  tggaggaga  gaaggaacc  2640
gctgtcgaa  agcccaaag  atccaaagt  gaagccaag  aggaagagg  tgaagataa  2700
aaaaaagtc  ccaccccag  gaaggaggc  cctgccaag  tggaggtga  ggaagacgc  2760
aaacccaaa  aaaagacag  ggtggccaa  aaggaacca  atgatgcca  ggccaagga  2820
cccagcaaa  cagcagaga  gaaggaggc  gcaccggag  aaaaagaca  caaggagga  2880
aaggccaag  agcctgagg  gaaacccaa  acagaggcc  aagccaagg  agatgacaa  2940
accctctca  aagagccta  caagcctaa  gcagaaaag  ctgaaaaat  ctccagcac  3000
gaccaaaaa  acagcaagc  tccagagaa  gccacagaa  acaaggccg  caaggggaa  3060
taaggcagg  agaaaggaa  atccggaac  gccaaagaa  ctcagaaga  tcccggagc  3120
caaggatca  agtaacaca  ttttcactt  ttctgtctt  atgtaagaa  aaactgctt  3180
gatgacggg  cctccttct  caaacagga  tttctgtta  caatatgtt  gcaagagag  3240
gcactccca  gcccctgcc  ccaggccct  cccaggcga  ggacaatta  gatagctta  3300
gtagctgaa  gtgatacat  ccgaatgcc  cacgtaaac  cttgactat  aaaactgcc  3360
ccctccttt  caaataagt  catttattg  ctctatgtg  aactgacag  tgaccgcaa  3420
aatgaatga  cagttagaa  tacattatg  ttgagatgt  ttaacctat  cccaaatgc  3480
ttctgtttt  caaaggagt  gtcaagccc  tgcccagag  tctctattc  ggaagagcg  3540
tccaggtgg  gccggggac  ggccactga  ttatgccag  gcgcacttt  cactggagt  3600
cactttcaa  tgcttctgt  caataaaac  aagtgctta  aaaatgaaa  tgttgctgc  3660
gttattctc  ttccctggg  aggctgggg  cagggcagg  gaggtctgg  tgtgacacc  3720
cagactgca  gggactgag  aagcatcagt  3750



<210> 9347
<211> 1020
<212> PRT
<213> Homo sapiens
<308> XP_037942
<400> 9347

Met Met Ser Phe Gly Gly Ala Asp Ala Leu Leu Gly Ala Pro Phe Ala 
  1               5                  10                  15
Pro Leu His Gly Gly Gly Ser Leu His Tyr Ala Leu Ala Arg Lys Gly 
             20                  25                  30
Gly Ala Gly Gly Thr Arg Ser Ala Ala Gly Ser Ser Ser Gly Phe His 
         35                  40                  45
Ser Trp Thr Arg Thr Ser Val Ser Ser Val Ser Ala Ser Pro Ser Arg 
     50                  55                  60
Phe Arg Gly Ala Gly Ala Ala Ser Ser Thr Asp Ser Leu Asp Thr Leu 
 65                  70                  75                  80
Ser Asn Gly Pro Glu Gly Cys Met Val Ala Val Ala Thr Ser Arg Ser 
                 85                  90                  95
Glu Lys Glu Gln Leu Gln Ala Leu Asn Asp Arg Phe Ala Gly Tyr Ile 
             100                105                110
Asp Lys Val Arg Gln Leu Glu Ala His Asn Arg Ser Leu Glu Gly Glu 
         115                120                125
Ala Ala Ala Leu Arg Gln Gln Gln Ala Gly Arg Ser Ala Met Gly Glu 
     130                135                140
Leu Tyr Glu Arg Glu Val Arg Glu Met Arg Gly Ala Val Leu Arg Leu 
 145                150                155                160
Gly Ala Ala Arg Gly Gln Leu Arg Leu Glu Gln Glu His Leu Leu Glu 
                 165                170                175
Asp Ile Ala His Val Arg Gln Arg Leu Asp Asp Glu Ala Arg Gln Arg 
             180                185                190
Glu Glu Ala Glu Ala Ala Ala Arg Ala Leu Ala Arg Phe Ala Gln Glu 
         195                200                205
Ala Glu Ala Ala Arg Val Asp Leu Gln Lys Lys Ala Gln Ala Leu Gln 
     210                215                220
Glu Glu Cys Gly Tyr Leu Arg Arg His His Gln Glu Glu Val Gly Glu 
 225                230                235                240
Leu Leu Gly Gln Ile Gln Gly Ser Gly Ala Ala Gln Ala Gln Met Gln 
                 245                250                255
Ala Glu Thr Arg Asp Ala Leu Lys Cys Asp Val Thr Ser Ala Leu Arg 
             260                265                270
Glu Ile Arg Ala Gln Leu Glu Gly His Ala Val Gln Ser Thr Leu Gln 
         275                280                285
Ser Glu Glu Trp Phe Arg Val Arg Leu Asp Arg Leu Ser Glu Ala Ala 
     290                295                300
Lys Val Asn Thr Asp Ala Met Arg Ser Ala Gln Glu Glu Ile Thr Glu 
 305                310                315                320
Tyr Arg Arg Gln Leu Gln Ala Arg Thr Thr Glu Leu Glu Ala Leu Lys 
                 325                330                335
Ser Thr Lys Asp Ser Leu Glu Arg Gln Arg Ser Glu Leu Glu Asp Arg 
             340                345                350
His Gln Ala Asp Ile Ala Ser Tyr Gln Glu Ala Ile Gln Gln Leu Asp 
         355                360                365
Ala Glu Leu Arg Asn Thr Lys Trp Glu Met Ala Ala Gln Leu Arg Glu 
     370                375                380
Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala 
 385                390                395                400
Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Ile Gly Phe Gly 
                 405                410                415
Pro Ile Pro Phe Ser Leu Pro Glu Gly Leu Pro Lys Ile Pro Ser Val 
             420                425                430
Ser Thr His Ile Lys Val Lys Ser Glu Glu Lys Ile Lys Val Val Glu 
         435                440                445
Lys Ser Glu Lys Glu Thr Val Ile Val Glu Glu Gln Thr Glu Glu Thr 
     450                455                460
Gln Val Thr Glu Glu Val Thr Glu Glu Glu Glu Lys Glu Ala Lys Glu 
 465                470                475                480
Glu Glu Gly Lys Glu Glu Glu Gly Gly Glu Glu Glu Glu Ala Glu Gly 
                 485                490                495
Gly Glu Glu Glu Thr Lys Ser Pro Pro Ala Glu Glu Ala Ala Ser Pro 
             500                505                510
Glu Lys Glu Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro Ala 
         515                520                525
Glu Ala Lys Ser Pro Glu Lys Glu Glu Ala Lys Ser Pro Ala Glu Val 
     530                535                540
Lys Ser Pro Glu Lys Ala Lys Ser Pro Ala Lys Glu Glu Ala Lys Ser 
 545                550                555                560
Pro Pro Glu Ala Lys Ser Pro Glu Lys Glu Glu Ala Lys Ser Pro Ala 
                 565                570                575
Glu Val Lys Ser Pro Glu Lys Ala Lys Ser Pro Ala Lys Glu Glu Ala 
             580                585                590
Lys Ser Pro Ala Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val 
         595                600                605
Lys Glu Glu Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro Val Lys Glu 
     610                615                620
Glu Ala Lys Ser Pro Ala Glu Val Lys Ser Pro Glu Lys Ala Lys Ser 
 625                630                635                640
Pro Thr Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Glu 
                 645                650                655
Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val Lys Ala 
             660                665                670
Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val Lys Ala Glu Ala 
         675                680                685
Lys Ser Pro Glu Lys Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Ser 
     690                695                700
Pro Glu Lys Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro Glu 
 705                710                715                720
Lys Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Thr Pro Glu Lys Ala 
                 725                730                735
Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser 
             740                745                750
Pro Glu Lys Ala Lys Thr Leu Asp Val Lys Ser Pro Glu Ala Lys Thr 
         755                760                765
Pro Ala Lys Glu Glu Ala Arg Ser Pro Ala Asp Lys Phe Pro Glu Lys 
     770                775                780
Ala Lys Ser Pro Val Lys Glu Glu Val Lys Ser Pro Glu Lys Ala Lys 
 785                790                795                800
Ser Pro Leu Lys Ala Asp Ala Lys Ala Pro Glu Lys Glu Ile Pro Lys 
                 805                810                815
Lys Glu Glu Val Lys Ser Pro Val Lys Glu Glu Glu Lys Pro Gln Glu 
             820                825                830
Val Lys Val Lys Glu Pro Pro Lys Lys Ala Glu Glu Glu Lys Ala Pro 
         835                840                845
Ala Thr Pro Lys Thr Glu Glu Lys Lys Asp Ser Lys Lys Glu Glu Ala 
     850                855                860
Pro Lys Lys Glu Ala Pro Lys Pro Lys Val Glu Glu Lys Lys Glu Pro 
 865                870                875                880
Ala Val Glu Lys Pro Lys Glu Ser Lys Val Glu Ala Lys Lys Glu Glu 
                 885                890                895
Ala Glu Asp Lys Lys Lys Val Pro Thr Pro Glu Lys Glu Ala Pro Ala 
             900                905                910
Lys Val Glu Val Lys Glu Asp Ala Lys Pro Lys Glu Lys Thr Glu Val 
         915                920                925
Ala Lys Lys Glu Pro Asp Asp Ala Lys Ala Lys Glu Pro Ser Lys Pro 
     930                935                940
Ala Glu Lys Lys Glu Ala Ala Pro Glu Lys Lys Asp Thr Lys Glu Glu 
 945                950                955                960
Lys Ala Lys Lys Pro Glu Glu Lys Pro Lys Thr Glu Ala Lys Ala Lys 
                 965                970                975
Glu Asp Asp Lys Thr Leu Ser Lys Glu Pro Ser Lys Pro Lys Ala Glu 
             980                985                990
Lys Ala Glu Lys Ser Ser Ser Thr Asp Gln Lys Asp Ser Lys Pro Pro 
         995                1000                1005
Glu Lys Ala Thr Glu Asp Lys Ala Ala Lys Gly Lys 
     1010                1015                1020



<210> 9348
<211> 654
<212> DNA
<213> Rattus norvegicus
<308> X13905
<400> 9348

ccgctgccg  catgaaccc  gaatatgac  acctgttta  gctgctttt  attggtgac  60
cgggcgtgg  caagtcatg  ctgcttctg  ggtttgctg  tgacacgta  acagagagc  120
acatcagca  cattggggt  gacttcaag  ttcgaacca  tgaactgga  ggcaaaacc  180
tcaaactac  gatttggga  acagctggt  aggaacggt  caggacagt  acttccagc  240
actatcggg  tgctcatgg  atcattgtg  tgtatgacg  cactgacca  gaatcctac  300
ctaatgtga  acagtggct  caggaaata  atcgctacg  cagtgagaa  gtcaataaa  360
tgctggtag  caacaagag  gacctcacc  ccaagaagg  cgtggacaa  accacagcc  420
aggaatttg  agactctct  ggtgtcccc  tcctggaga  aagtgccaa  aatgccacc  480
atgttgaac  ggcattcat  acaatggct  cagagatca  aaaacggat  gggccagga  540
cagcatctg  gggtgaacg  cccaacctg  agatcgaca  cactcctgt  aaatctgct  600
gtggtggct  ctgctaggg  ggggtactt  gggagggca  ttctccaga  gatg  654



<210> 9349
<211> 201
<212> PRT
<213> Rattus norvegicus
<308> CAA32105
<400> 9349

Met Asn Pro Glu Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp 
  1               5                  10                  15
Ser Gly Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala Asp Asp Thr 
             20                  25                  30
Tyr Thr Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe Lys Ile Arg 
         35                  40                  45
Thr Ile Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile Trp Asp Thr 
     50                  55                  60
Ala Gly Gln Glu Arg Phe Arg Thr Val Thr Ser Ser Tyr Tyr Arg Gly 
 65                  70                  75                  80
Ala His Gly Ile Ile Val Val Tyr Asp Val Thr Asp Gln Glu Ser Tyr 
                 85                  90                  95
Ala Asn Val Lys Gln Trp Leu Gln Glu Ile Asp Arg Tyr Ala Ser Glu 
             100                105                110
Asn Val Asn Lys Leu Leu Val Gly Asn Lys Ser Asp Leu Thr Thr Lys 
         115                120                125
Lys Val Val Asp Asn Thr Thr Ala Lys Glu Phe Ala Asp Ser Leu Gly 
     130                135                140
Val Pro Phe Leu Glu Thr Ser Ala Lys Asn Ala Thr Asn Val Glu Gln 
 145                150                155                160
Ala Phe Met Thr Met Ala Ala Glu Ile Lys Lys Arg Met Gly Pro Gly 
                 165                170                175
Ala Ala Ser Gly Gly Glu Arg Pro Asn Leu Lys Ile Asp Ser Thr Pro 
             180                185                190
Val Lys Ser Ala Ser Gly Gly Cys Cys 
         195                200



<210> 9350
<211> 723
<212> DNA
<213> Homo sapiens
<308> NM_004161
<400> 9350

gggcggcgg  cggcagcaa  gcggcggtg  gccgccgca  ctgcagtga  atgtccagc  60
tgaatcccg  atatgatta  ttattcaag  tacttctga  tggcgactc  ggggttgga  120
agtcttgcc  tcttcttag  tttgcagat  atacatata  agaaagcta  atcagcaca  180
ttggtgtgg  tttcaaaat  agaactata  agttagacg  gaaaacaat  aagcttcaa  240
tatgggaca  agcaggcca  gaaagattt  gaacaatca  ctccagtta  tacagagga  300
cccatggca  catagttgt  tatgatgtg  cagatcagg  gtccttcaa  aatgttaaa  360
agtggctgc  ggaaataga  cgttatgcc  gtgaaaatg  caacaaatt  ttggtaggg  420
acaaatgtg  tctgaccac  aagaaagta  tagactaca  aacagcgaa  gaatttgct  480
attcccttg  aattccgtt  ttggaaacc  gtgctaaga  tgcaacgaa  gtagaacag  540
ctttcatga  gatggcagc  gagattaaa  agcgaatgg  tcccggagc  acagctggt  600
gtgctgaga  gtccaatgt  aaaattcag  gcactccag  caagcagtc  ggtggaggt  660
gctgctaaa  ttgcctcca  ccttttctc  cagcaatga  tttgcaatc  gaacccaag  720
gaa  723



<210> 9351
<211> 205
<212> PRT
<213> Homo sapiens
<308> P11476
<400> 9351

Met Ser Ser Met Asn Pro Glu Tyr Asp Tyr Leu Phe Lys Leu Leu Leu 
  1               5                  10                  15
Ile Gly Asp Ser Gly Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala 
             20                  25                  30
Asp Asp Thr Tyr Thr Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe 
         35                  40                  45
Lys Ile Arg Thr Ile Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile 
     50                  55                  60
Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Ser Ser Tyr 
 65                  70                  75                  80
Tyr Arg Gly Ala His Gly Ile Ile Val Val Tyr Asp Val Thr Asp Gln 
                 85                  90                  95
Glu Ser Phe Asn Asn Val Lys Gln Trp Leu Gln Glu Ile Asp Arg Tyr 
             100                105                110
Ala Ser Glu Asn Val Asn Lys Leu Leu Val Gly Asn Lys Cys Asp Leu 
         115                120                125
Thr Thr Lys Lys Val Val Asp Tyr Thr Thr Ala Lys Glu Phe Ala Asp 
     130                135                140
Ser Leu Gly Ile Pro Phe Leu Glu Thr Ser Ala Lys Asn Ala Thr Asn 
 145                150                155                160
Val Glu Gln Ser Phe Met Thr Met Ala Ala Glu Ile Lys Lys Arg Met 
                 165                170                175
Gly Pro Gly Ala Thr Ala Gly Gly Ala Glu Lys Ser Asn Val Lys Ile 
             180                185                190
Gln Ser Thr Pro Val Lys Gln Ser Gly Gly Gly Cys Cys 
         195                200                205



<210> 9352
<211> 654
<212> DNA
<213> Rattus norvegicus
<308> X13905
<400> 9352

ccgctgccg  catgaaccc  gaatatgac  acctgttta  gctgctttt  attggtgac  60
cgggcgtgg  caagtcatg  ctgcttctg  ggtttgctg  tgacacgta  acagagagc  120
acatcagca  cattggggt  gacttcaag  ttcgaacca  tgaactgga  ggcaaaacc  180
tcaaactac  gatttggga  acagctggt  aggaacggt  caggacagt  acttccagc  240
actatcggg  tgctcatgg  atcattgtg  tgtatgacg  cactgacca  gaatcctac  300
ctaatgtga  acagtggct  caggaaata  atcgctacg  cagtgagaa  gtcaataaa  360
tgctggtag  caacaagag  gacctcacc  ccaagaagg  cgtggacaa  accacagcc  420
aggaatttg  agactctct  ggtgtcccc  tcctggaga  aagtgccaa  aatgccacc  480
atgttgaac  ggcattcat  acaatggct  cagagatca  aaaacggat  gggccagga  540
cagcatctg  gggtgaacg  cccaacctg  agatcgaca  cactcctgt  aaatctgct  600
gtggtggct  ctgctaggg  ggggtactt  gggagggca  ttctccaga  gatg  654



<210> 9353
<211> 201
<212> PRT
<213> Rattus norvegicus
<308> CAA32105
<400> 9353

Met Asn Pro Glu Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp 
  1               5                  10                  15
Ser Gly Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala Asp Asp Thr 
             20                  25                  30
Tyr Thr Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe Lys Ile Arg 
         35                  40                  45
Thr Ile Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile Trp Asp Thr 
     50                  55                  60
Ala Gly Gln Glu Arg Phe Arg Thr Val Thr Ser Ser Tyr Tyr Arg Gly 
 65                  70                  75                  80
Ala His Gly Ile Ile Val Val Tyr Asp Val Thr Asp Gln Glu Ser Tyr 
                 85                  90                  95
Ala Asn Val Lys Gln Trp Leu Gln Glu Ile Asp Arg Tyr Ala Ser Glu 
             100                105                110
Asn Val Asn Lys Leu Leu Val Gly Asn Lys Ser Asp Leu Thr Thr Lys 
         115                120                125
Lys Val Val Asp Asn Thr Thr Ala Lys Glu Phe Ala Asp Ser Leu Gly 
     130                135                140
Val Pro Phe Leu Glu Thr Ser Ala Lys Asn Ala Thr Asn Val Glu Gln 
 145                150                155                160
Ala Phe Met Thr Met Ala Ala Glu Ile Lys Lys Arg Met Gly Pro Gly 
                 165                170                175
Ala Ala Ser Gly Gly Glu Arg Pro Asn Leu Lys Ile Asp Ser Thr Pro 
             180                185                190
Val Lys Ser Ala Ser Gly Gly Cys Cys 
         195                200



<210> 9354
<211> 723
<212> DNA
<213> Homo sapiens
<308> NM_004161
<400> 9354

gggcggcgg  cggcagcaa  gcggcggtg  gccgccgca  ctgcagtga  atgtccagc  60
tgaatcccg  atatgatta  ttattcaag  tacttctga  tggcgactc  ggggttgga  120
agtcttgcc  tcttcttag  tttgcagat  atacatata  agaaagcta  atcagcaca  180
ttggtgtgg  tttcaaaat  agaactata  agttagacg  gaaaacaat  aagcttcaa  240
tatgggaca  agcaggcca  gaaagattt  gaacaatca  ctccagtta  tacagagga  300
cccatggca  catagttgt  tatgatgtg  cagatcagg  gtccttcaa  aatgttaaa  360
agtggctgc  ggaaataga  cgttatgcc  gtgaaaatg  caacaaatt  ttggtaggg  420
acaaatgtg  tctgaccac  aagaaagta  tagactaca  aacagcgaa  gaatttgct  480
attcccttg  aattccgtt  ttggaaacc  gtgctaaga  tgcaacgaa  gtagaacag  540
ctttcatga  gatggcagc  gagattaaa  agcgaatgg  tcccggagc  acagctggt  600
gtgctgaga  gtccaatgt  aaaattcag  gcactccag  caagcagtc  ggtggaggt  660
gctgctaaa  ttgcctcca  ccttttctc  cagcaatga  tttgcaatc  gaacccaag  720
gaa  723



<210> 9355
<211> 205
<212> PRT
<213> Homo sapiens
<308> P11476
<400> 9355

Met Ser Ser Met Asn Pro Glu Tyr Asp Tyr Leu Phe Lys Leu Leu Leu 
  1               5                  10                  15
Ile Gly Asp Ser Gly Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala 
             20                  25                  30
Asp Asp Thr Tyr Thr Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe 
         35                  40                  45
Lys Ile Arg Thr Ile Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile 
     50                  55                  60
Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Ser Ser Tyr 
 65                  70                  75                  80
Tyr Arg Gly Ala His Gly Ile Ile Val Val Tyr Asp Val Thr Asp Gln 
                 85                  90                  95
Glu Ser Phe Asn Asn Val Lys Gln Trp Leu Gln Glu Ile Asp Arg Tyr 
             100                105                110
Ala Ser Glu Asn Val Asn Lys Leu Leu Val Gly Asn Lys Cys Asp Leu 
         115                120                125
Thr Thr Lys Lys Val Val Asp Tyr Thr Thr Ala Lys Glu Phe Ala Asp 
     130                135                140
Ser Leu Gly Ile Pro Phe Leu Glu Thr Ser Ala Lys Asn Ala Thr Asn 
 145                150                155                160
Val Glu Gln Ser Phe Met Thr Met Ala Ala Glu Ile Lys Lys Arg Met 
                 165                170                175
Gly Pro Gly Ala Thr Ala Gly Gly Ala Glu Lys Ser Asn Val Lys Ile 
             180                185                190
Gln Ser Thr Pro Val Lys Gln Ser Gly Gly Gly Cys Cys 
         195                200                205



<210> 9356
<211> 1446
<212> DNA
<213> Rattus norvegicus
<308> X13933
<400> 9356

acgcacaac  caggtagcg  gttagcagc  gcagcggag  catctcggc  gtcacagcc  60
ctgcgctgt  cagccaccc  cgcctgccg  tcttccttc  ttcgctcgc  ccatggctg  120
tcagctgac  gaagaacag  ttgctgaat  caaggaagc  ttctcccta  ttgataaag  180
tggggacgg  accatcaca  caaaggagc  ggggactgt  atgcggtca  tgggtcaga  240
cccaacaga  gctgaactg  aggatatga  caacgaggt  gatgccgac  ggaatggca  300
cattgactt  ccagagttc  tgactatga  ggctagaaa  atgaaagac  cagatagcg  360
agaagaaat  cgtgaggca  tccgagtct  tgacaagga  ggcaatggc  acatcagtg  420
ggcagaact  cgccacgtc  tgacaaacc  cggggaaaa  ctaacagat  aagaagtag  480
cgaaatgat  agagaagca  atattgatg  agacggaca  gtcaactat  aagaattcg  540
acagatgat  actgcaaaa  gaagaccta  tttcaacta  tttccccct  tagaagaat  600
aaattgaaa  cttttactt  cctcttaca  aaaaaaaaa  agaaaaaag  aaaaagttc  660
tttcttcat  ctgtttgta  ctagcaaaa  tgaatgtca  aagtacctt  tgtccacac  720
caaaatctg  atgtattgg  tggtggtcc  gccccctaa  gatcaagcc  cctacatga  780
ttttacagt  taaatactc  tactacctt  taaggaagc  cttagtgac  ccttcaagt  840
ccatttgct  atgattaac  cactgtctg  gctggccag  ttctcatgc  tgcagcttg  900
tgattgagc  cagtcaggc  tttgtatta  aactgaaaa  tggaaaaaa  aaattcaaa  960
tctcagatg  cttctagtt  aatctgttc  gataaatgt  agcagccag  ttaccgcaa  1020
caaacattt  aaattggtt  acctcagga  gatgtgcag  aaacgggtg  aggctaaac  1080
ttgagacac  gccctagat  taggacagt  ctcttcaag  gccccaatc  catggtgac  1140
gtgacaccc  ggtggcgag  ccgagtgtg  tggttcacc  ctgtgcaca  tgcattgga  1200
tgaagtgaa  aaggctgtc  ccaaatcac  cacgtttta  taagaaatg  ttactaagg  1260
agcatcttt  gactctctg  tttaaaacc  tgtgaacca  gactcggag  cagcagagt  1320
ggctgtgtc  gtggacttg  gcacaccat  aacattgct  ttcaggaaa  tataattta  1380
gtccattcc  agttgtaaa  gctagtctt  tattttttt  ttccaataa  aagaccatt  1440
acttaa  1446



<210> 9357
<211> 148
<212> PRT
<213> Rattus norvegicus
<308> P02593
<400> 9357

Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala Phe 
  1               5                  10                  15
Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu Leu 
             20                  25                  30
Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu 
         35                  40                  45
Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile Asp 
     50                  55                  60
Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr Asp 
 65                  70                  75                  80
Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly 
                 85                  90                  95
Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn Leu 
             100                105                110
Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala 
         115                120                125
Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met 
     130                135                140
Met Thr Ala Lys 
 145



<210> 9358
<211> 110
<212> DNA
<213> Homo sapiens
<308> AI802286
<400> 9358

agagatgaa  ggctgcaga  atgtttatt  aatacagtg  caggtttat  aataaaacg  60
atttacaat  tccatagag  tggtccccc  tcagagagg  ggttaaatct  110



<210> 9359
<211> 149
<212> PRT
<213> Homo sapiens
<308> AAH08437
<400> 9359

Met Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
  1               5                  10                  15
Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
             20                  25                  30
Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
         35                  40                  45
Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 
     50                  55                  60
Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr 
 65                  70                  75                  80
Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp 
                 85                  90                  95
Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 
             100                105                110
Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Gln Met Ile Arg Glu 
         115                120                125
Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln 
     130                135                140
Met Met Thr Ala Lys 
 145



<210> 9360
<211> 1525
<212> DNA
<213> Rattus norvegicus
<308> X13983
<400> 9360

caaggatca  atgtgagct  tcgtattgc  aagctcttc  ctgatttaa  gccaactcc  60
tttaccacc  tcctaagta  ttaggcatt  ccttcagga  aaaagaaat  tcatttcat  120
tcattaaga  catcgtcgc  acccttgaa  atgtatgtc  ttttaaagc  tagaaggcc  180
cttgcccat  tccttcctc  gccaagtca  cactcagaa  ttatggctt  ctttagatt  240
ctgcttcct  ccacgttgt  tccagccca  atacagtgt  tctctggca  ctgccctca  300
gagacttca  cttctctaa  gatatcggt  ggctactca  atgcaaaat  tgtcctatc  360
cctgccccg  atcttggaa  ttttatggg  tctgacttc  acttatttg  cattctatc  420
ctaggtcct  gccaaggag  acccatgaa  ggttagaaa  aaccaagga  ctgcagcaa  480
gagaggatg  atgcatgat  taatgaaat  gcctccagg  cctggagac  agagagggg  540
gtgttgggc  aaagtgttt  tgtagtgaa  ggcaaagtc  gctggggtg  tggttaggc  600
cagtaaaaa  gggttattt  acacttgtt  cttttcacc  tcttaaaac  gaaatgagt  660
tatgtgaag  ttaaggtca  tgttatgtt  tactggaat  tagaaattc  ctgtgaagg  720
tacacttac  gaccagcaa  cccaagacc  tcctgtctc  tgtcctcca  aacccagat  780
ctagctaag  attaggaaa  ctaatcatt  ctcctggcc  cgacacttc  ttttcagtc  840
atctaatgt  taataatac  tctaaagtc  atacctact  cctagtttg  ttcaaaatg  900
tttccatag  agggtgctg  tcatgggcc  cacgttaaa  acaggcctt  tgtggccca  960
agcttgctg  cacactccg  tggagtgaa  tattcaagc  tcccagggc  gcttaagcc  1020
cagcctcct  gccaactat  cagacagaa  ctcagagca  ccctaagag  ctgtggggg  1080
ggagaagcc  attatcaag  ttcatgtac  aaagagaaa  agtgagcag  aactggaaa  1140
tccttaatc  ttctgggaa  tctggctaa  gggtcagga  ttaaccttg  cggtaatta  1200
gccatcagt  actctttca  agaatgttc  aaaacctca  ctttgtttg  agaactcgt  1260
tgggtggga  cagctgttt  cacaaagaa  agcataaag  ctagctgct  ctcaccacg  1320
ccaggacca  atctctggc  gggagtagg  tgcaaggca  ccaggtctc  gatcctttc  1380
gcagcatgg  gaagcacag  ctccggagc  tggccctgc  gccactgct  ctgcgcctg  1440
tgctgctgc  gctgcccac  gatgcctca  ctccacaaa  accgtgagt  cagcaaacg  1500
cagacgctt  gatttaggg  ttctg  1525



<210> 9361
<211> 1472
<212> PRT
<213> Rattus norvegicus
<308> NP_036620
<400> 9361

Met Gly Lys His Arg Leu Arg Ser Leu Ala Leu Leu Pro Leu Leu Leu 
  1               5                  10                  15
Arg Leu Leu Leu Leu Leu Leu Pro Thr Asp Ala Ser Ala Pro Gln Lys 
             20                  25                  30
Pro Ile Tyr Met Val Met Val Pro Ser Leu Leu His Ala Gly Thr Pro 
         35                  40                  45
Glu Lys Ala Cys Phe Leu Phe Ser His Leu Asn Glu Thr Val Ala Val 
     50                  55                  60
Arg Val Ser Leu Glu Ser Val His Gly Asn Gln Ser Leu Phe Thr Asp 
 65                  70                  75                  80
Leu Val Val Asp Lys Asp Leu Phe His Cys Thr Ser Phe Thr Val Pro 
                 85                  90                  95
Gln Ser Ser Ser Asp Glu Leu Met Phe Phe Thr Val Gln Val Lys Gly 
             100                105                110
Ala Thr His Glu Phe Arg Arg Gln Ser Thr Val Leu Val Lys Lys Lys 
         115                120                125
Glu Ser Leu Val Phe Ala Gln Thr Asp Lys Pro Ile Tyr Lys Pro Gly 
     130                135                140
Gln Thr Val Arg Phe Arg Val Val Ser Leu Asp Glu Ser Phe His Pro 
 145                150                155                160
Leu Asn Glu Leu Ile Pro Leu Leu Tyr Ile Gln Asp Pro Lys Asn Asn 
                 165                170                175
Arg Ile Ala Gln Trp Gln Asn Phe Asn Leu Glu Gly Gly Leu Lys Gln 
             180                185                190
Leu Ser Phe Pro Leu Ser Ser Glu Pro Thr Gln Gly Ser Tyr Lys Val 
         195                200                205
Val Ile Arg Thr Glu Ser Gly Arg Thr Val Glu His Pro Phe Ser Val 
     210                215                220
Glu Glu Phe Val Leu Pro Lys Phe Glu Val Arg Val Thr Val Pro Glu 
 225                230                235                240
Thr Ile Thr Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Ile 
                 245                250                255
Tyr Thr Tyr Gly Lys Pro Val Pro Gly Arg Val Thr Val Asn Ile Cys 
             260                265                270
Arg Lys Tyr Ser Asn Pro Ser Asn Cys Phe Gly Glu Glu Ser Val Ala 
         275                280                285
Phe Cys Glu Lys Leu Ser Gln Gln Leu Asp Gly Arg Gly Cys Phe Ser 
     290                295                300
Gln Leu Val Lys Thr Lys Ser Phe Gln Leu Lys Arg Gln Glu Tyr Glu 
 305                310                315                320
Met Gln Leu Asp Val His Ala Lys Ile Gln Glu Glu Gly Thr Gly Val 
                 325                330                335
Glu Glu Thr Gly Lys Gly Leu Thr Lys Ile Thr Arg Thr Ile Thr Lys 
             340                345                350
Leu Ser Phe Val Asn Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe 
         355                360                365
Val Gly Gln Val Leu Leu Val Asp Gly Arg Gly Thr Pro Ile Pro Tyr 
     370                375                380
Glu Thr Ile Phe Ile Gly Ala Asp Glu Ala Asn Leu Tyr Ile Asn Thr 
 385                390                395                400
Thr Thr Asp Lys His Gly Leu Ala Arg Phe Ser Ile Asn Thr Asp Asp 
                 405                410                415
Ile Met Gly Thr Ser Leu Thr Val Arg Ala Lys Tyr Lys Asp Ser Asn 
             420                425                430
Ala Cys Tyr Gly Phe Arg Trp Leu Thr Glu Glu Asn Val Glu Ala Trp 
         435                440                445
His Thr Ala Tyr Ala Val Phe Ser Pro Ser Arg Ser Phe Leu His Leu 
     450                455                460
Glu Ser Leu Pro Asp Lys Leu Arg Cys Asp Gln Thr Leu Glu Val Gln 
 465                470                475                480
Ala His Tyr Ile Leu Asn Gly Glu Ala Met Gln Glu Leu Lys Glu Leu 
                 485                490                495
Val Phe Tyr Tyr Leu Met Met Ala Lys Gly Gly Ile Val Arg Ala Gly 
             500                505                510
Thr His Val Leu Pro Leu Lys Gln Gly Gln Met Arg Gly His Phe Ser 
         515                520                525
Ile Leu Ile Ser Met Glu Thr Asp Leu Ala Pro Val Ala Arg Leu Val 
     530                535                540
Leu Tyr Ala Ile Leu Pro Asn Gly Glu Val Val Gly Asp Thr Ala Lys 
 545                550                555                560
Tyr Glu Ile Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Val Phe Arg 
                 565                570                575
Pro Asn Ser Gly Leu Pro Ala Thr Arg Ala Leu Leu Ser Val Met Ala 
             580                585                590
Ser Pro Gln Ser Leu Cys Gly Leu Arg Ala Val Asp Gln Ser Val Leu 
         595                600                605
Leu Met Lys Pro Glu Thr Glu Leu Ser Ala Ser Leu Ile Tyr Asp Leu 
     610                615                620
Leu Pro Val Lys Asp Leu Thr Gly Phe Pro Gln Gly Ala Asp Gln Arg 
 625                630                635                640
Glu Glu Asp Thr Asn Gly Cys Val Lys Gln Asn Asp Thr Tyr Ile Asn 
                 645                650                655
Gly Ile Leu Tyr Ser Pro Val Gln Asn Thr Asn Glu Glu Asp Met Tyr 
             660                665                670
Gly Phe Leu Lys Asp Met Gly Leu Lys Val Phe Thr Asn Ser Asn Ile 
         675                680                685
Arg Lys Pro Lys Val Cys Glu Arg Leu Arg Asp Asn Lys Gly Ile Pro 
     690                695                700
Ala Ala Tyr His Leu Val Ser Gln Ser His Met Asp Ala Phe Leu Glu 
 705                710                715                720
Ser Ser Glu Ser Pro Thr Glu Thr Arg Arg Ser Tyr Phe Pro Glu Thr 
                 725                730                735
Trp Ile Trp Asp Leu Val Val Val Asp Ser Ala Gly Val Ala Glu Val 
             740                745                750
Glu Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly Ala Phe 
         755                760                765
Cys Leu Ser Asn Asp Thr Gly Leu Gly Leu Ser Pro Val Val Gln Phe 
     770                775                780
Gln Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr Ser Val 
 785                790                795                800
Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn Tyr Leu 
                 805                810                815
Pro Thr Cys Ile Arg Val Ala Val Gln Leu Glu Ala Ser Pro Asp Phe 
             820                825                830
Leu Ala Ala Pro Glu Glu Lys Glu Gln Arg Ser His Cys Ile Cys Met 
         835                840                845
Asn Gln Arg His Thr Ala Ser Trp Ala Val Ile Pro Lys Ser Leu Gly 
     850                855                860
Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Asn Ser Lys Glu Leu 
 865                870                875                880
Cys Gly Asn Glu Val Pro Val Val Pro Glu Gln Gly Lys Lys Asp Thr 
                 885                890                895
Ile Ile Lys Ser Leu Leu Val Glu Pro Glu Gly Leu Glu Asn Glu Val 
             900                905                910
Thr Phe Asn Ser Leu Leu Cys Pro Met Gly Ala Glu Val Ser Glu Leu 
         915                920                925
Ile Ala Leu Lys Leu Pro Ser Asp Val Val Glu Glu Ser Ala Arg Ala 
     930                935                940
Ser Val Thr Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln Asn Thr 
 945                950                955                960
Gln Asp Leu Leu Lys Met Pro Tyr Gly Cys Gly Glu Gln Asn Met Val 
                 965                970                975
Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu Thr Gln 
             980                985                990
Gln Leu Thr Gln Glu Ile Lys Thr Lys Ala Ile Ala Tyr Leu Asn Thr 
         995                1000                1005
Gly Tyr Gln Arg Gln Leu Asn Tyr Lys His Arg Asp Gly Ser Tyr Ser 
     1010                1015                1020
Ala Phe Gly Asp Lys Pro Gly Arg Asn His Ala Asn Thr Trp Leu Thr 
 1025                1030                1035                1040
Ala Phe Val Leu Lys Ser Phe Ala Gln Ala Arg Lys Tyr Ile Phe Ile 
                 1045                1050                1055
Asp Glu Val His Ile Thr Gln Ala Leu Leu Trp Leu Ser Gln Gln Gln 
             1060                1065                1070
Lys Asp Asn Gly Cys Phe Arg Ser Ser Gly Ser Leu Leu Asn Asn Ala 
         1075                1080                1085
Met Lys Gly Gly Val Glu Asp Glu Val Thr Leu Ser Ala Tyr Ile Thr 
     1090                1095                1100
Ile Ala Leu Leu Glu Met Ser Leu Pro Val Thr His Pro Val Val Arg 
 1105                1110                1115                1120
Asn Ala Leu Phe Cys Leu Asp Thr Ala Trp Lys Ser Ala Arg Gly Gly 
                 1125                1130                1135
Ala Gly Gly Ser His Val Tyr Thr Lys Ala Leu Leu Ala Tyr Ala Phe 
             1140                1145                1150
Ala Leu Ala Gly Asn Gln Asp Thr Lys Lys Glu Ile Leu Lys Ser Leu 
         1155                1160                1165
Asp Glu Glu Ala Val Lys Glu Glu Asp Ser Val His Trp Thr Arg Pro 
     1170                1175                1180
Gln Lys Pro Ser Val Ser Val Gly Leu Trp Tyr Gln Pro Gln Ala Thr 
 1185                1190                1195                1200
Ser Ala Glu Val Glu Met Thr Ala Tyr Val Leu Leu Ala Tyr Leu Thr 
                 1205                1210                1215
Thr Glu Pro Ala Pro Thr Gln Glu Asp Leu Thr Ala Ala Met Leu Ile 
             1220                1225                1230
Val Lys Trp Leu Thr Lys Gln Gln Asn Ser His Gly Gly Phe Ser Ser 
         1235                1240                1245
Thr Gln Asp Thr Val Val Ala Leu His Ala Leu Ser Lys Tyr Gly Ser 
     1250                1255                1260
Ala Thr Phe Thr Arg Ala Lys Lys Ala Ala Gln Val Thr Ile Arg Ser 
 1265                1270                1275                1280
Ser Gly Thr Phe Ser Thr Lys Phe Gln Val Asn Asn Asn Asn Gln Leu 
                 1285                1290                1295
Leu Leu Gln Arg Val Thr Leu Pro Thr Val Pro Gly Asp Tyr Thr Val 
             1300                1305                1310
Lys Val Thr Gly Glu Gly Cys Val Tyr Leu Gln Thr Ser Leu Lys Tyr 
         1315                1320                1325
Ser Val Leu Pro Arg Glu Glu Glu Phe Pro Phe Ala Val Val Val Gln 
     1330                1335                1340
Thr Leu Pro Gly Thr Cys Glu Asp Pro Lys Ala His Thr Ser Phe Gln 
 1345                1350                1355                1360
Ile Ser Leu Asn Ile Ser Tyr Thr Gly Ser Arg Ser Glu Ser Asn Met 
                 1365                1370                1375
Ala Ile Ala Asp Val Lys Met Val Ser Gly Phe Ile Pro Leu Lys Pro 
             1380                1385                1390
Thr Val Lys Met Leu Glu Arg Ser Val His Val Ser Arg Thr Glu Val 
         1395                1400                1405
Ser Asn Asn His Val Leu Ile Tyr Leu Asp Lys Val Ser Asn Gln Thr 
     1410                1415                1420
Val Asn Leu Ser Phe Thr Val Gln Gln Asp Ile Pro Ile Arg Asp Leu 
 1425                1430                1435                1440
Lys Pro Ala Val Val Lys Val Tyr Asp Tyr Tyr Glu Lys Asp Glu Phe 
                 1445                1450                1455
Ala Val Ala Lys Tyr Ser Ala Pro Cys Ser Thr Asp Tyr Gly Asn Ala 
             1460                1465                1470



<210> 9362
<211> 4576
<212> DNA
<213> Homo sapiens
<308> XM_006925
<400> 9362

tacaataca  tctgttctc  tccagctcc  tctttctgc  acatgggga  gaacaaact  60
cttcatcca  gtctggttc  tctcctctt  gtcctcctg  ccacagacg  ctcagtctc  120
ggaaaaccg  agtatatgg  tctggtccc  tccctgctc  acactgaga  cactgagaa  180
ggctgtgtc  ttctgagct  cctgaatga  acagtgact  taagtgctt  cttggagtc  240
gtcagggga  acaggagcc  cttcactga  ctggaggcg  agaatgacg  actccactg  300
gtcgccttc  ctgtcccaa  gtcttcatc  aatgaggag  taatgttcc  cactgtcca  360
gtgaaagga  caacccaag  atttaagaa  cggaccaca  tgatggtta  gaacgagga  420
agtctggtc  ttgtccaga  agacaaatc  atctacaaa  cagggcaga  agtgaaatt  480
cgtgttgtc  ccatggatg  aaactttca  cccctgaat  agttgattc  actagtata  540
attcaggat  ccaaaggaa  tcgcatcgc  caatggcag  gtttccagt  agagggtgg  600
ctcaagcaa  tttcttttc  cctctcatc  gagcccttc  agggctcct  caaggtggt  660
gtacagaag  aatcaggtg  aaggacaga  caccctttc  ccgtggagg  atttgttct  720
cccaagttt  aagtacaag  aacagtgcc  aagataatc  ccatcttgg  agaagagat  780
aatgtatca  tgtgtggcc  atacacata  gggaagcct  tccctggac  tgtgactgt  840
agcatttgc  gaaagtata  tgacgcttc  gactgccac  gtgaagatt  acaggcttt  900
tgtgagaaa  tcagtggac  gctaaacag  catggctgc  tctatcagc  agtaaaaac  960
aaggtcttc  agctgaaga  gaaggagta  gaaatgaaa  ttcacactg  ggcccagat  1020
caagaagaa  gaacagtgg  ggaattgac  ggaaggcag  ccagtgaaa  cacaagaac  1080
ataaccaaa  tctcatttg  gaaagtgga  tcacacttt  gacagggaa  tcccttctt  1140
gggcaggtg  gcctagtag  tgggaaagg  gtccctata  caaataaag  catattcat  1200
agaggaaat  aagcaaact  ttactccaa  gctaccacg  atgagcatg  ccttgtaca  1260
ttctctatc  acaccacca  tgttatggg  acctctctt  ctgttaggg  caattacaa  1320
gatcgtagt  cctgttacg  ctaccagtg  gtgtcagaa  aacacgaag  ggcacatca  1380
actgcttat  ttgtgttct  cccaagcaa  agctttgtc  accttgagc  catgtctca  1440
gaactaccc  gtggccata  tcagacagt  caggcacat  atattctga  tggaggcac  1500
ctgctgggg  tgaagaagc  ctccttcta  tatctgata  tggcaaagg  aggcattgt  1560
cgaactggg  ctcatggac  gcttgtgaa  caggaagac  tgaagggcc  tttttccat  1620
tcaatccct  tgaagtcag  cattgctcc  gtcgctcgg  tgctcatct  tgctgtttt  1680
cctaccggg  acgtgattg  ggattctgc  aaatatgat  ttgaaaatt  tctggccaa  1740
aaggtggat  tgagcttca  cccatcaca  agtctccca  cctcacacg  ccacctgcg  1800
gtcacagcg  ctcctcagt  cgtctgcgc  ctccgtgct  tggaccaaa  cgtgctgct  1860
atgaagcct  atgctgagc  ctcggcgtc  tcggtttac  acctgctac  agaaaagga  1920
ctcactggc  tccctgggc  tttgaatga  caggacaat  aagactgca  caatcgtca  1980
aatgtctat  ttaatggaa  cacatatac  ccagtatca  gtacaaatg  aaaggatat  2040
tacagcttc  tagaggaca  gggcttaaa  gcattcacc  actcaaaga  tcgtaaacc  2100
aaaatgtgt  cacagcttc  acagtatga  atgcatgga  ctgaaggtc  acgtgtagg  2160
ttttatgag  cagatgtaa  gggaagagg  catgcacgc  tggtgcatg  tgaagagcc  2220
cacacggag  ccgtacgaa  gtacttccc  gagacatgg  tctgggatt  ggtggtggt  2280
aactcagca  gtgtggctg  ggtaggagt  acagtccct  acaccatca  cgagtggaa  2340
gcaggggcc  tctgcctgt  tgaagatgc  ggacttggt  tctcttcca  tgcctctct  2400
cgagccttc  agcccttct  tgtggagct  acaatgcct  actctgtga  tcgtggaga  2460
gccttcaca  tcaaggcca  ggtcctaaa  taccttccc  aatgcatcc  ggtcagtgt  2520
cagctggaa  cctctcccg  cttcctagc  gtcccagtg  agaaggaac  agcgcctca  2580
tgcatctgt  caaacgggc  gcaaactgt  tcctgggca  taaccccaa  gtcattagg  2640
aatgtgaat  tcactgtga  cgcagaggc  ctagagtct  aagagctgt  tgggactga  2700
gtgccttca  ttcctgaac  cggaaggaa  gacacagtc  tcaagcctc  gttggttga  2760
cctgaagga  tagagaagg  aacaacatt  aactcccta  tttgtccat  aggtggtga  2820
gtttctgaa  aattatccc  gaaactgcc  ccaaatgtg  tagaagaat  tgcccgagc  2880
tctgtctca  ttttgggag  catattagg  tctgccatg  aaaacacac  aaatcttct  2940
cagatgccc  atggctgtg  agagcagaa  atggtcctc  ttgctccta  catctatgt  3000
ctggattat  taaatgaaa  acagcagct  actccagag  tcaagtcca  ggccattgg  3060
tatctcaac  ctggttacc  gagacagtt  aactacaaa  actatgatg  ctcctacag  3120
acctttggg  agcgatatg  caggaacca  ggcaacacc  ggctcacag  ctttgttct  3180
aagactttt  cccaagctc  agcctacat  ttcatcgat  aagcacaca  tacccaagc  3240
ctcatatgg  tctcccaga  gcagaagga  aatggctgt  tcaggagct  tgggtcact  3300
ctcaacaat  ccataaagg  aggagtaga  gatgaagtg  ccctctccg  ctatatcac  3360
atcgccctt  tggagattc  tctcacagt  actcaccct  ttgtccgca  tgccctgtt  3420
tgcctggag  cagcctgga  gacagcaca  gaaggggac  atggcagcc  tgtatatac  3480
aaagcactg  tggcctatg  ttttgccct  gcaggtaac  aggacaaga  gaaggaagt  3540
ctcaagtca  ttaatgagg  agctgtgaa  aaagacaac  ctgtccatt  ggagcgccc  3600
cagaaaccc  aggcaccag  ggggcattt  tacgaaccc  aggctccct  tgctgaggt  3660
gagatgaca  cctatgtgc  cctcgctta  ctcacggcc  agccagccc  aacctcgga  3720
gacctgacc  ctgcaacca  catcgtgaa  tggatcacg  agcagcaga  tgcccaggg  3780
ggtttctcc  ccacccagg  cacagtggt  gctctccat  ctctgtcca  atatggagc  3840
gccacattt  ccaggactg  gaaggctgc  caggtgact  tccagtctt  agggacatt  3900
tccagcaaa  tccaagtgg  caacaacaa  cgcctgtta  tgcagcagg  ctcattgcc  3960
gagctgcct  gggaataca  catgaaagt  acaggagaa  gatgtgtct  cctccagac  4020
tccttgaaa  acaatattc  cccagaaaa  gaagagttc  cctttgctt  aggagtgca  4080
actctgcct  aaacttgtg  tgaacccaa  gcccacacc  gcttccaaa  ctccctaag  4140
gtcagttac  cagggagcc  ctctgcctc  aacatggcg  tcgttgatg  gaagatggt  4200
tctggcttc  ttcccctga  gccaacagt  aaaatgctt  aaagatcta  ccatgtgag  4260
cggacagaa  tcagcagca  ccatgtctt  atttacctt  ataaggtgt  aaatcagac  4320
ctgagcttg  tcttcacgg  tctgcaaga  gtcccagta  gagatctga  accagccat  4380
gtgaaagtc  atgattact  cgagacgga  gagtttgca  ttgctgagt  caatgctcc  4440
tgcagcaaa  atcttggaa  tgcttgaag  ccacaaggc  gaaaagtgc  ttgctggag  4500
cctgttctc  gagctccac  gaagacacg  gtttttgta  ctttaaaga  ttgatgaat  4560
aacactttt  ctggtc  4576



<210> 9363
<211> 1474
<212> PRT
<213> Homo sapiens
<308> XP_006925
<400> 9363

Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
  1               5                  10                  15
Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
             20                  25                  30
Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys 
         35                  40                  45
Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu 
     50                  55                  60
Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu 
 65                  70                  75                  80
Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                 85                  90                  95
Asn Glu Glu Val Met Phe Leu Thr Val Gln Val Lys Gly Pro Thr Gln 
             100                105                110
Glu Phe Lys Lys Arg Thr Thr Val Met Val Lys Asn Glu Asp Ser Leu 
         115                120                125
Val Phe Val Gln Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val 
     130                135                140
Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
 145                150                155                160
Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala 
                 165                170                175
Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe Ser Phe 
             180                185                190
Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys Val Val Val Gln 
         195                200                205
Lys Lys Ser Gly Gly Arg Thr Glu His Pro Phe Thr Val Glu Glu Phe 
     210                215                220
Val Leu Pro Lys Phe Glu Val Gln Val Thr Val Pro Lys Ile Ile Thr 
 225                230                235                240
Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Leu Tyr Thr Tyr 
                 245                250                255
Gly Lys Pro Val Pro Gly His Val Thr Val Ser Ile Cys Arg Lys Tyr 
             260                265                270
Ser Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu 
         275                280                285
Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val 
     290                295                300
Lys Thr Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met Lys Leu 
 305                310                315                320
His Thr Glu Ala Gln Ile Gln Glu Glu Gly Thr Val Val Glu Leu Thr 
                 325                330                335
Gly Arg Gln Ser Ser Glu Ile Thr Arg Thr Ile Thr Lys Leu Ser Phe 
             340                345                350
Val Lys Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe Phe Gly Gln 
         355                360                365
Val Arg Leu Val Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile 
     370                375                380
Phe Ile Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp 
 385                390                395                400
Glu His Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly 
                 405                410                415
Thr Ser Leu Thr Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys Tyr 
             420                425                430
Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His His Thr Ala 
         435                440                445
Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val His Leu Glu Pro Met 
     450                455                460
Ser His Glu Leu Pro Cys Gly His Thr Gln Thr Val Gln Ala His Tyr 
 465                470                475                480
Ile Leu Asn Gly Gly Thr Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr 
                 485                490                495
Tyr Leu Ile Met Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly 
             500                505                510
Leu Leu Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile 
         515                520                525
Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala 
     530                535                540
Val Leu Pro Thr Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp Val 
 545                550                555                560
Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ser Gln 
                 565                570                575
Ser Leu Pro Ala Ser His Ala His Leu Arg Val Thr Ala Ala Pro Gln 
             580                585                590
Ser Val Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys 
         595                600                605
Pro Asp Ala Glu Leu Ser Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu 
     610                615                620
Lys Asp Leu Thr Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asn Glu 
 625                630                635                640
Asp Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Thr Tyr Thr 
                 645                650                655
Pro Val Ser Ser Thr Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp 
             660                665                670
Met Gly Leu Lys Ala Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Met 
         675                680                685
Cys Pro Gln Leu Gln Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg 
     690                695                700
Val Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His Ala Arg Leu 
 705                710                715                720
Val His Val Glu Glu Pro His Thr Glu Thr Val Arg Lys Tyr Phe Pro 
                 725                730                735
Glu Thr Trp Ile Trp Asp Leu Val Val Val Asn Ser Ala Gly Val Ala 
             740                745                750
Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly 
         755                760                765
Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala 
     770                775                780
Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr 
 785                790                795                800
Ser Val Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn 
                 805                810                815
Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln Leu Glu Ala Ser Pro 
             820                825                830
Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys Ile 
         835                840                845
Cys Ala Asn Gly Arg Gln Thr Val Ser Trp Ala Val Thr Pro Lys Ser 
     850                855                860
Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu Ser Gln 
 865                870                875                880
Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg Lys 
                 885                890                895
Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys 
             900                905                910
Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val Ser 
         915                920                925
Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser Ala 
     930                935                940
Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln 
 945                950                955                960
Asn Thr Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln Asn 
                 965                970                975
Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu 
             980                985                990
Thr Gln Gln Leu Thr Pro Glu Ile Lys Ser Lys Ala Ile Gly Tyr Leu 
         995                1000                1005
Asn Thr Gly Tyr Gln Arg Gln Leu Asn Tyr Lys His Tyr Asp Gly Ser 
     1010                1015                1020
Tyr Ser Thr Phe Gly Glu Arg Tyr Gly Arg Asn Gln Gly Asn Thr Trp 
 1025                1030                1035                1040
Leu Thr Ala Phe Val Leu Lys Thr Phe Ala Gln Ala Arg Ala Tyr Ile 
                 1045                1050                1055
Phe Ile Asp Glu Ala His Ile Thr Gln Ala Leu Ile Trp Leu Ser Gln 
             1060                1065                1070
Arg Gln Lys Asp Asn Gly Cys Phe Arg Ser Ser Gly Ser Leu Leu Asn 
         1075                1080                1085
Asn Ala Ile Lys Gly Gly Val Glu Asp Glu Val Thr Leu Ser Ala Tyr 
     1090                1095                1100
Ile Thr Ile Ala Leu Leu Glu Ile Pro Leu Thr Val Thr His Pro Val 
 1105                1110                1115                1120
Val Arg Asn Ala Leu Phe Cys Leu Glu Ser Ala Trp Lys Thr Ala Gln 
                 1125                1130                1135
Glu Gly Asp His Gly Ser His Val Tyr Thr Lys Ala Leu Leu Ala Tyr 
             1140                1145                1150
Ala Phe Ala Leu Ala Gly Asn Gln Asp Lys Arg Lys Glu Val Leu Lys 
         1155                1160                1165
Ser Leu Asn Glu Glu Ala Val Lys Lys Asp Asn Ser Val His Trp Glu 
     1170                1175                1180
Arg Pro Gln Lys Pro Lys Ala Pro Val Gly His Phe Tyr Glu Pro Gln 
 1185                1190                1195                1200
Ala Pro Ser Ala Glu Val Glu Met Thr Ser Tyr Val Leu Leu Ala Tyr 
                 1205                1210                1215
Leu Thr Ala Gln Pro Ala Pro Thr Ser Glu Asp Leu Thr Ser Ala Thr 
             1220                1225                1230
Asn Ile Val Lys Trp Ile Thr Lys Gln Gln Asn Ala Gln Gly Gly Phe 
         1235                1240                1245
Ser Ser Thr Gln Asp Thr Val Val Ala Leu His Ala Leu Ser Lys Tyr 
     1250                1255                1260
Gly Ala Ala Thr Phe Thr Arg Thr Gly Lys Ala Ala Gln Val Thr Ile 
 1265                1270                1275                1280
Gln Ser Ser Gly Thr Phe Ser Ser Lys Phe Gln Val Asp Asn Asn Asn 
                 1285                1290                1295
Arg Leu Leu Leu Gln Gln Val Ser Leu Pro Glu Leu Pro Gly Glu Tyr 
             1300                1305                1310
Ser Met Lys Val Thr Gly Glu Gly Cys Val Tyr Leu Gln Thr Ser Leu 
         1315                1320                1325
Lys Tyr Asn Ile Leu Pro Glu Lys Glu Glu Phe Pro Phe Ala Leu Gly 
     1330                1335                1340
Val Gln Thr Leu Pro Gln Thr Cys Asp Glu Pro Lys Ala His Thr Ser 
 1345                1350                1355                1360
Phe Gln Ile Ser Leu Ser Val Ser Tyr Thr Gly Ser Arg Ser Ala Ser 
                 1365                1370                1375
Asn Met Ala Ile Val Asp Val Lys Met Val Ser Gly Phe Ile Pro Leu 
             1380                1385                1390
Lys Pro Thr Val Lys Met Leu Glu Arg Ser Asn His Val Ser Arg Thr 
         1395                1400                1405
Glu Val Ser Ser Asn His Val Leu Ile Tyr Leu Asp Lys Val Ser Asn 
     1410                1415                1420
Gln Thr Leu Ser Leu Phe Phe Thr Val Leu Gln Asp Val Pro Val Arg 
 1425                1430                1435                1440
Asp Leu Lys Pro Ala Ile Val Lys Val Tyr Asp Tyr Tyr Glu Thr Asp 
                 1445                1450                1455
Glu Phe Ala Ile Ala Glu Tyr Asn Ala Pro Cys Ser Lys Asp Leu Gly 
             1460                1465                1470
Asn Ala 
         1475



<210> 9364
<211> 591
<212> DNA
<213> Rattus norvegicus
<308> X14181
<400> 9364

cttttgtga  tggcagtga  cgagcacgc  ctgctatga  ggcgtcggg  acgcttcgg  60
agtacaagg  ggtggggcg  tgcttgcca  ccccaaaat  ccacacacc  ccactgtac  120
gaatgcgaa  ctttgcacc  aaccatgtg  tggccaagt  ccgcttctg  tactttgtg  180
cgcagctga  gaagatgaa  aagtcatcc  gggaaattg  gtactgtgg  caggtgttt  240
agaagtcac  cctgcgtgt  aagaacttc  gcatctggc  gcgctatga  tcccgaagt  300
gcactcaca  catgtaccg  gagtaccgg  acctgacca  tgccggcgc  gtcacacag  360
gctaccgag  catgggtgc  cgacaccgt  cccgtgcgc  ctccatcca  atcatgaag  420
tggaagaga  tgcagctgg  aagtgccgc  ggccagctg  caagcagtt  cacgactcc  480
agatcaagt  cccattgcc  caccgtgtg  tgcggcgcc  gcacaaacc  cgcttcacc  540
ccaagaggc  aaacacctt  ttctagaca  cagagaccc  ctgaataaa  g  591



<210> 9365
<211> 176
<212> PRT
<213> Rattus norvegicus
<308> CAA32385
<400> 9365

Met Lys Ala Ser Gly Thr Leu Arg Glu Tyr Lys Val Val Gly Arg Cys 
  1               5                  10                  15
Leu Pro Thr Pro Lys Cys His Thr Pro Pro Leu Tyr Arg Met Arg Ile 
             20                  25                  30
Phe Ala Pro Asn His Val Val Ala Lys Ser Arg Phe Trp Tyr Phe Val 
         35                  40                  45
Ser Gln Leu Lys Lys Met Lys Lys Ser Ser Gly Glu Ile Val Tyr Cys 
     50                  55                  60
Gly Gln Val Phe Glu Lys Ser Pro Leu Arg Val Lys Asn Phe Gly Ile 
 65                  70                  75                  80
Trp Leu Arg Tyr Asp Ser Arg Ser Gly Thr His Asn Met Tyr Arg Glu 
                 85                  90                  95
Tyr Arg Asp Leu Thr Thr Ala Gly Ala Val Thr Gln Cys Tyr Arg Asp 
             100                105                110
Met Gly Ala Arg His Arg Ala Arg Ala His Ser Ile Gln Ile Met Lys 
         115                120                125
Val Glu Glu Ile Ala Ala Gly Lys Cys Arg Arg Pro Ala Val Lys Gln 
     130                135                140
Phe His Asp Ser Lys Ile Lys Phe Pro Leu Pro His Arg Val Leu Arg 
 145                150                155                160
Arg Gln His Lys Pro Arg Phe Thr Thr Lys Arg Pro Asn Thr Phe Phe 
                 165                170                175



<210> 9366
<211> 618
<212> DNA
<213> Homo sapiens
<308> NM_000980
<400> 9366

cttttgcgg  tggcggcga  cgcggagag  acgccatga  ggcctcggg  acgctacga  60
agtacaagg  agtgggtcg  tgcctgccc  cccccaaat  ccacacgcc  cccctctac  120
gcatgcgaa  ctttgcgcc  aatcatgtc  tcgccaagt  ccgcttctg  tactttgta  180
ctcagttaa  gaagatgaa  aagtcttca  gggagattg  ctactgtgg  caggtgttt  240
agaagtccc  cctgcgggt  aagaacttc  ggatctggc  gcgctatga  tcccggagc  300
gcacccaca  catgtaccg  gaataccgg  acctgacca  cgcaggcgc  gtcacccag  360
gctaccgag  catgggtgc  cggcaccgc  cccgagccc  ctccattca  atcatgaag  420
tggaggaga  cgcggccag  aagtgccgc  ggccggctg  caagcagtt  cacgactcc  480
agatcaagt  cccgctgcc  caccgggtc  tgcgccgtc  gcacaagcc  cgcttcacc  540
ccaagaggc  caacacctt  ttctaggtg  agggccctc  tccgggtgt  ccccaaata  600
actcaggaa  gccccggt  618



<210> 9367
<211> 176
<212> PRT
<213> Homo sapiens
<308> Q02543
<400> 9367

Met Lys Ala Ser Gly Thr Leu Arg Glu Tyr Lys Val Val Gly Arg Cys 
  1               5                  10                  15
Leu Pro Thr Pro Lys Cys His Thr Pro Pro Leu Tyr Arg Met Arg Ile 
             20                  25                  30
Phe Ala Pro Asn His Val Val Ala Lys Ser Arg Phe Trp Tyr Phe Val 
         35                  40                  45
Ser Gln Leu Lys Lys Met Lys Lys Ser Ser Gly Glu Ile Val Tyr Cys 
     50                  55                  60
Gly Gln Val Phe Glu Lys Ser Pro Leu Arg Val Lys Asn Phe Gly Ile 
 65                  70                  75                  80
Trp Leu Arg Tyr Asp Ser Arg Ser Gly Thr His Asn Met Tyr Arg Glu 
                 85                  90                  95
Tyr Arg Asp Leu Thr Thr Ala Gly Ala Val Thr Gln Cys Tyr Arg Asp 
             100                105                110
Met Gly Ala Arg His Arg Ala Arg Ala His Ser Ile Gln Ile Met Lys 
         115                120                125
Val Glu Glu Ile Ala Ala Ser Lys Cys Arg Arg Pro Ala Val Lys Gln 
     130                135                140
Phe His Asp Ser Lys Ile Lys Phe Pro Leu Pro His Arg Val Leu Arg 
 145                150                155                160
Arg Gln His Lys Pro Arg Phe Thr Thr Lys Arg Pro Asn Thr Phe Phe 
                 165                170                175



<210> 9368
<211> 591
<212> DNA
<213> Rattus norvegicus
<308> X14181
<400> 9368

cttttgtga  tggcagtga  cgagcacgc  ctgctatga  ggcgtcggg  acgcttcgg  60
agtacaagg  ggtggggcg  tgcttgcca  ccccaaaat  ccacacacc  ccactgtac  120
gaatgcgaa  ctttgcacc  aaccatgtg  tggccaagt  ccgcttctg  tactttgtg  180
cgcagctga  gaagatgaa  aagtcatcc  gggaaattg  gtactgtgg  caggtgttt  240
agaagtcac  cctgcgtgt  aagaacttc  gcatctggc  gcgctatga  tcccgaagt  300
gcactcaca  catgtaccg  gagtaccgg  acctgacca  tgccggcgc  gtcacacag  360
gctaccgag  catgggtgc  cgacaccgt  cccgtgcgc  ctccatcca  atcatgaag  420
tggaagaga  tgcagctgg  aagtgccgc  ggccagctg  caagcagtt  cacgactcc  480
agatcaagt  cccattgcc  caccgtgtg  tgcggcgcc  gcacaaacc  cgcttcacc  540
ccaagaggc  aaacacctt  ttctagaca  cagagaccc  ctgaataaa  g  591



<210> 9369
<211> 176
<212> PRT
<213> Rattus norvegicus
<308> CAA32385
<400> 9369

Met Lys Ala Ser Gly Thr Leu Arg Glu Tyr Lys Val Val Gly Arg Cys 
  1               5                  10                  15
Leu Pro Thr Pro Lys Cys His Thr Pro Pro Leu Tyr Arg Met Arg Ile 
             20                  25                  30
Phe Ala Pro Asn His Val Val Ala Lys Ser Arg Phe Trp Tyr Phe Val 
         35                  40                  45
Ser Gln Leu Lys Lys Met Lys Lys Ser Ser Gly Glu Ile Val Tyr Cys 
     50                  55                  60
Gly Gln Val Phe Glu Lys Ser Pro Leu Arg Val Lys Asn Phe Gly Ile 
 65                  70                  75                  80
Trp Leu Arg Tyr Asp Ser Arg Ser Gly Thr His Asn Met Tyr Arg Glu 
                 85                  90                  95
Tyr Arg Asp Leu Thr Thr Ala Gly Ala Val Thr Gln Cys Tyr Arg Asp 
             100                105                110
Met Gly Ala Arg His Arg Ala Arg Ala His Ser Ile Gln Ile Met Lys 
         115                120                125
Val Glu Glu Ile Ala Ala Gly Lys Cys Arg Arg Pro Ala Val Lys Gln 
     130                135                140
Phe His Asp Ser Lys Ile Lys Phe Pro Leu Pro His Arg Val Leu Arg 
 145                150                155                160
Arg Gln His Lys Pro Arg Phe Thr Thr Lys Arg Pro Asn Thr Phe Phe 
                 165                170                175



<210> 9370
<211> 618
<212> DNA
<213> Homo sapiens
<308> NM_000980
<400> 9370

cttttgcgg  tggcggcga  cgcggagag  acgccatga  ggcctcggg  acgctacga  60
agtacaagg  agtgggtcg  tgcctgccc  cccccaaat  ccacacgcc  cccctctac  120
gcatgcgaa  ctttgcgcc  aatcatgtc  tcgccaagt  ccgcttctg  tactttgta  180
ctcagttaa  gaagatgaa  aagtcttca  gggagattg  ctactgtgg  caggtgttt  240
agaagtccc  cctgcgggt  aagaacttc  ggatctggc  gcgctatga  tcccggagc  300
gcacccaca  catgtaccg  gaataccgg  acctgacca  cgcaggcgc  gtcacccag  360
gctaccgag  catgggtgc  cggcaccgc  cccgagccc  ctccattca  atcatgaag  420
tggaggaga  cgcggccag  aagtgccgc  ggccggctg  caagcagtt  cacgactcc  480
agatcaagt  cccgctgcc  caccgggtc  tgcgccgtc  gcacaagcc  cgcttcacc  540
ccaagaggc  caacacctt  ttctaggtg  agggccctc  tccgggtgt  ccccaaata  600
actcaggaa  gccccggt  618



<210> 9371
<211> 176
<212> PRT
<213> Homo sapiens
<308> Q02543
<400> 9371

Met Lys Ala Ser Gly Thr Leu Arg Glu Tyr Lys Val Val Gly Arg Cys 
  1               5                  10                  15
Leu Pro Thr Pro Lys Cys His Thr Pro Pro Leu Tyr Arg Met Arg Ile 
             20                  25                  30
Phe Ala Pro Asn His Val Val Ala Lys Ser Arg Phe Trp Tyr Phe Val 
         35                  40                  45
Ser Gln Leu Lys Lys Met Lys Lys Ser Ser Gly Glu Ile Val Tyr Cys 
     50                  55                  60
Gly Gln Val Phe Glu Lys Ser Pro Leu Arg Val Lys Asn Phe Gly Ile 
 65                  70                  75                  80
Trp Leu Arg Tyr Asp Ser Arg Ser Gly Thr His Asn Met Tyr Arg Glu 
                 85                  90                  95
Tyr Arg Asp Leu Thr Thr Ala Gly Ala Val Thr Gln Cys Tyr Arg Asp 
             100                105                110
Met Gly Ala Arg His Arg Ala Arg Ala His Ser Ile Gln Ile Met Lys 
         115                120                125
Val Glu Glu Ile Ala Ala Ser Lys Cys Arg Arg Pro Ala Val Lys Gln 
     130                135                140
Phe His Asp Ser Lys Ile Lys Phe Pro Leu Pro His Arg Val Leu Arg 
 145                150                155                160
Arg Gln His Lys Pro Arg Phe Thr Thr Lys Arg Pro Asn Thr Phe Phe 
                 165                170                175



<210> 9372
<211> 591
<212> DNA
<213> Rattus norvegicus
<308> X14181
<400> 9372

cttttgtga  tggcagtga  cgagcacgc  ctgctatga  ggcgtcggg  acgcttcgg  60
agtacaagg  ggtggggcg  tgcttgcca  ccccaaaat  ccacacacc  ccactgtac  120
gaatgcgaa  ctttgcacc  aaccatgtg  tggccaagt  ccgcttctg  tactttgtg  180
cgcagctga  gaagatgaa  aagtcatcc  gggaaattg  gtactgtgg  caggtgttt  240
agaagtcac  cctgcgtgt  aagaacttc  gcatctggc  gcgctatga  tcccgaagt  300
gcactcaca  catgtaccg  gagtaccgg  acctgacca  tgccggcgc  gtcacacag  360
gctaccgag  catgggtgc  cgacaccgt  cccgtgcgc  ctccatcca  atcatgaag  420
tggaagaga  tgcagctgg  aagtgccgc  ggccagctg  caagcagtt  cacgactcc  480
agatcaagt  cccattgcc  caccgtgtg  tgcggcgcc  gcacaaacc  cgcttcacc  540
ccaagaggc  aaacacctt  ttctagaca  cagagaccc  ctgaataaa  g  591



<210> 9373
<211> 176
<212> PRT
<213> Rattus norvegicus
<308> CAA32385
<400> 9373

Met Lys Ala Ser Gly Thr Leu Arg Glu Tyr Lys Val Val Gly Arg Cys 
  1               5                  10                  15
Leu Pro Thr Pro Lys Cys His Thr Pro Pro Leu Tyr Arg Met Arg Ile 
             20                  25                  30
Phe Ala Pro Asn His Val Val Ala Lys Ser Arg Phe Trp Tyr Phe Val 
         35                  40                  45
Ser Gln Leu Lys Lys Met Lys Lys Ser Ser Gly Glu Ile Val Tyr Cys 
     50                  55                  60
Gly Gln Val Phe Glu Lys Ser Pro Leu Arg Val Lys Asn Phe Gly Ile 
 65                  70                  75                  80
Trp Leu Arg Tyr Asp Ser Arg Ser Gly Thr His Asn Met Tyr Arg Glu 
                 85                  90                  95
Tyr Arg Asp Leu Thr Thr Ala Gly Ala Val Thr Gln Cys Tyr Arg Asp 
             100                105                110
Met Gly Ala Arg His Arg Ala Arg Ala His Ser Ile Gln Ile Met Lys 
         115                120                125
Val Glu Glu Ile Ala Ala Gly Lys Cys Arg Arg Pro Ala Val Lys Gln 
     130                135                140
Phe His Asp Ser Lys Ile Lys Phe Pro Leu Pro His Arg Val Leu Arg 
 145                150                155                160
Arg Gln His Lys Pro Arg Phe Thr Thr Lys Arg Pro Asn Thr Phe Phe 
                 165                170                175



<210> 9374
<211> 618
<212> DNA
<213> Homo sapiens
<308> NM_000980
<400> 9374

cttttgcgg  tggcggcga  cgcggagag  acgccatga  ggcctcggg  acgctacga  60
agtacaagg  agtgggtcg  tgcctgccc  cccccaaat  ccacacgcc  cccctctac  120
gcatgcgaa  ctttgcgcc  aatcatgtc  tcgccaagt  ccgcttctg  tactttgta  180
ctcagttaa  gaagatgaa  aagtcttca  gggagattg  ctactgtgg  caggtgttt  240
agaagtccc  cctgcgggt  aagaacttc  ggatctggc  gcgctatga  tcccggagc  300
gcacccaca  catgtaccg  gaataccgg  acctgacca  cgcaggcgc  gtcacccag  360
gctaccgag  catgggtgc  cggcaccgc  cccgagccc  ctccattca  atcatgaag  420
tggaggaga  cgcggccag  aagtgccgc  ggccggctg  caagcagtt  cacgactcc  480
agatcaagt  cccgctgcc  caccgggtc  tgcgccgtc  gcacaagcc  cgcttcacc  540
ccaagaggc  caacacctt  ttctaggtg  agggccctc  tccgggtgt  ccccaaata  600
actcaggaa  gccccggt  618



<210> 9375
<211> 176
<212> PRT
<213> Homo sapiens
<308> Q02543
<400> 9375

Met Lys Ala Ser Gly Thr Leu Arg Glu Tyr Lys Val Val Gly Arg Cys 
  1               5                  10                  15
Leu Pro Thr Pro Lys Cys His Thr Pro Pro Leu Tyr Arg Met Arg Ile 
             20                  25                  30
Phe Ala Pro Asn His Val Val Ala Lys Ser Arg Phe Trp Tyr Phe Val 
         35                  40                  45
Ser Gln Leu Lys Lys Met Lys Lys Ser Ser Gly Glu Ile Val Tyr Cys 
     50                  55                  60
Gly Gln Val Phe Glu Lys Ser Pro Leu Arg Val Lys Asn Phe Gly Ile 
 65                  70                  75                  80
Trp Leu Arg Tyr Asp Ser Arg Ser Gly Thr His Asn Met Tyr Arg Glu 
                 85                  90                  95
Tyr Arg Asp Leu Thr Thr Ala Gly Ala Val Thr Gln Cys Tyr Arg Asp 
             100                105                110
Met Gly Ala Arg His Arg Ala Arg Ala His Ser Ile Gln Ile Met Lys 
         115                120                125
Val Glu Glu Ile Ala Ala Ser Lys Cys Arg Arg Pro Ala Val Lys Gln 
     130                135                140
Phe His Asp Ser Lys Ile Lys Phe Pro Leu Pro His Arg Val Leu Arg 
 145                150                155                160
Arg Gln His Lys Pro Arg Phe Thr Thr Lys Arg Pro Asn Thr Phe Phe 
                 165                170                175



<210> 9376
<211> 591
<212> DNA
<213> Rattus norvegicus
<308> X14181
<400> 9376

cttttgtga  tggcagtga  cgagcacgc  ctgctatga  ggcgtcggg  acgcttcgg  60
agtacaagg  ggtggggcg  tgcttgcca  ccccaaaat  ccacacacc  ccactgtac  120
gaatgcgaa  ctttgcacc  aaccatgtg  tggccaagt  ccgcttctg  tactttgtg  180
cgcagctga  gaagatgaa  aagtcatcc  gggaaattg  gtactgtgg  caggtgttt  240
agaagtcac  cctgcgtgt  aagaacttc  gcatctggc  gcgctatga  tcccgaagt  300
gcactcaca  catgtaccg  gagtaccgg  acctgacca  tgccggcgc  gtcacacag  360
gctaccgag  catgggtgc  cgacaccgt  cccgtgcgc  ctccatcca  atcatgaag  420
tggaagaga  tgcagctgg  aagtgccgc  ggccagctg  caagcagtt  cacgactcc  480
agatcaagt  cccattgcc  caccgtgtg  tgcggcgcc  gcacaaacc  cgcttcacc  540
ccaagaggc  aaacacctt  ttctagaca  cagagaccc  ctgaataaa  g  591



<210> 9377
<211> 176
<212> PRT
<213> Rattus norvegicus
<308> CAA32385
<400> 9377

Met Lys Ala Ser Gly Thr Leu Arg Glu Tyr Lys Val Val Gly Arg Cys 
  1               5                  10                  15
Leu Pro Thr Pro Lys Cys His Thr Pro Pro Leu Tyr Arg Met Arg Ile 
             20                  25                  30
Phe Ala Pro Asn His Val Val Ala Lys Ser Arg Phe Trp Tyr Phe Val 
         35                  40                  45
Ser Gln Leu Lys Lys Met Lys Lys Ser Ser Gly Glu Ile Val Tyr Cys 
     50                  55                  60
Gly Gln Val Phe Glu Lys Ser Pro Leu Arg Val Lys Asn Phe Gly Ile 
 65                  70                  75                  80
Trp Leu Arg Tyr Asp Ser Arg Ser Gly Thr His Asn Met Tyr Arg Glu 
                 85                  90                  95
Tyr Arg Asp Leu Thr Thr Ala Gly Ala Val Thr Gln Cys Tyr Arg Asp 
             100                105                110
Met Gly Ala Arg His Arg Ala Arg Ala His Ser Ile Gln Ile Met Lys 
         115                120                125
Val Glu Glu Ile Ala Ala Gly Lys Cys Arg Arg Pro Ala Val Lys Gln 
     130                135                140
Phe His Asp Ser Lys Ile Lys Phe Pro Leu Pro His Arg Val Leu Arg 
 145                150                155                160
Arg Gln His Lys Pro Arg Phe Thr Thr Lys Arg Pro Asn Thr Phe Phe 
                 165                170                175



<210> 9378
<211> 618
<212> DNA
<213> Homo sapiens
<308> NM_000980
<400> 9378

cttttgcgg  tggcggcga  cgcggagag  acgccatga  ggcctcggg  acgctacga  60
agtacaagg  agtgggtcg  tgcctgccc  cccccaaat  ccacacgcc  cccctctac  120
gcatgcgaa  ctttgcgcc  aatcatgtc  tcgccaagt  ccgcttctg  tactttgta  180
ctcagttaa  gaagatgaa  aagtcttca  gggagattg  ctactgtgg  caggtgttt  240
agaagtccc  cctgcgggt  aagaacttc  ggatctggc  gcgctatga  tcccggagc  300
gcacccaca  catgtaccg  gaataccgg  acctgacca  cgcaggcgc  gtcacccag  360
gctaccgag  catgggtgc  cggcaccgc  cccgagccc  ctccattca  atcatgaag  420
tggaggaga  cgcggccag  aagtgccgc  ggccggctg  caagcagtt  cacgactcc  480
agatcaagt  cccgctgcc  caccgggtc  tgcgccgtc  gcacaagcc  cgcttcacc  540
ccaagaggc  caacacctt  ttctaggtg  agggccctc  tccgggtgt  ccccaaata  600
actcaggaa  gccccggt  618



<210> 9379
<211> 176
<212> PRT
<213> Homo sapiens
<308> Q02543
<400> 9379

Met Lys Ala Ser Gly Thr Leu Arg Glu Tyr Lys Val Val Gly Arg Cys 
  1               5                  10                  15
Leu Pro Thr Pro Lys Cys His Thr Pro Pro Leu Tyr Arg Met Arg Ile 
             20                  25                  30
Phe Ala Pro Asn His Val Val Ala Lys Ser Arg Phe Trp Tyr Phe Val 
         35                  40                  45
Ser Gln Leu Lys Lys Met Lys Lys Ser Ser Gly Glu Ile Val Tyr Cys 
     50                  55                  60
Gly Gln Val Phe Glu Lys Ser Pro Leu Arg Val Lys Asn Phe Gly Ile 
 65                  70                  75                  80
Trp Leu Arg Tyr Asp Ser Arg Ser Gly Thr His Asn Met Tyr Arg Glu 
                 85                  90                  95
Tyr Arg Asp Leu Thr Thr Ala Gly Ala Val Thr Gln Cys Tyr Arg Asp 
             100                105                110
Met Gly Ala Arg His Arg Ala Arg Ala His Ser Ile Gln Ile Met Lys 
         115                120                125
Val Glu Glu Ile Ala Ala Ser Lys Cys Arg Arg Pro Ala Val Lys Gln 
     130                135                140
Phe His Asp Ser Lys Ile Lys Phe Pro Leu Pro His Arg Val Leu Arg 
 145                150                155                160
Arg Gln His Lys Pro Arg Phe Thr Thr Lys Arg Pro Asn Thr Phe Phe 
                 165                170                175



<210> 9380
<211> 907
<212> DNA
<213> Rattus norvegicus
<308> X14210
<400> 9380

tctttccgt  cccagcgca  catggctcg  ggtcccaag  aacatctga  gcgcgtagc  60
gctccaaaa  actggatgc  ggataagct  actggcgtg  ttgctcctc  tccatccac  120
ggtccacac  aactgaggg  atgcctgcc  ctgatcatt  tcctaagga  cagacttaa  180
tatgccctg  ctggagatg  agtaaaaaa  atttgcatg  agcgattca  taagattga  240
gggaaagtc  ggaccgata  aacctaccc  gctgggttt  tggatgtca  cagcattga  300
aagactgga  agaacttcc  tctgatcta  gacaccaag  gtcgctttg  tgtccatcg  360
attacacct  aggaggcca  gtacaagtt  tgcaaagtg  gaaagatct  tgtgggcac  420
aaaggaatc  cacatctgg  gacccatga  gcccgtact  ttcgatacc  tgatcccct  480
atcaaggtg  atgacacca  tcagattga  ttggaaaca  gcaagataa  tgatttcat  540
aagttcgac  ctgggaacc  gtgtatggt  actggaggt  ctaacttgg  gagaattgg  600
gtaatcacc  atagggaga  acatcctgg  tcttttgat  tggttcatg  gaaagatgc  660
aacggcaac  gctttgcca  tcgtctttc  aacattttt  ttattggca  gggcaacaa  720
ccgtggatt  ctcttcccc  aggaaaagg  atccgcctt  ccattgctg  agagagaga  780
aagaggcta  cagccaaac  gagcagtgg  tgaaatggt  tctaggaga  atgctggag  840
agtatttgt  cctcaacac  acaagcctt  ctaagcaac  tgctagatt  aacagcatg  900
tgaaatc  907



<210> 9381
<211> 262
<212> PRT
<213> Rattus norvegicus
<308> CAA32427
<400> 9381

Ala Arg Gly Pro Lys Lys His Leu Lys Arg Val Ala Ala Pro Lys His 
  1               5                  10                  15
Trp Met Leu Asp Lys Leu Thr Gly Val Phe Ala Pro Arg Pro Ser Thr 
             20                  25                  30
Gly Pro His Lys Leu Arg Glu Cys Leu Pro Leu Ile Ile Phe Leu Arg 
         35                  40                  45
Asn Arg Leu Lys Tyr Ala Leu Thr Gly Asp Glu Val Lys Lys Ile Cys 
     50                  55                  60
Met Gln Arg Phe Ile Lys Ile Asp Gly Lys Val Arg Thr Asp Ile Thr 
 65                  70                  75                  80
Tyr Pro Ala Gly Phe Met Asp Val Ile Ser Ile Asp Lys Thr Gly Glu 
                 85                  90                  95
Asn Phe Arg Leu Ile Tyr Asp Thr Lys Gly Arg Phe Ala Val His Arg 
             100                105                110
Ile Thr Pro Glu Glu Ala Lys Tyr Lys Leu Cys Lys Val Arg Lys Ile 
         115                120                125
Phe Val Gly Thr Lys Gly Ile Pro His Leu Val Thr His Asp Ala Arg 
     130                135                140
Thr Ile Arg Tyr Pro Asp Pro Leu Ile Lys Val Asn Asp Thr Ile Gln 
 145                150                155                160
Ile Asp Leu Glu Thr Gly Lys Ile Thr Asp Phe Ile Lys Phe Asp Thr 
                 165                170                175
Gly Asn Leu Cys Met Val Thr Gly Gly Ala Asn Leu Gly Arg Ile Gly 
             180                185                190
Val Ile Thr Asn Arg Glu Arg His Pro Gly Ser Phe Asp Val Val His 
         195                200                205
Val Lys Asp Ala Asn Gly Asn Ser Phe Ala Thr Arg Leu Ser Asn Ile 
     210                215                220
Phe Val Ile Gly Lys Gly Asn Lys Pro Trp Ile Ser Leu Pro Arg Gly 
 225                230                235                240
Lys Gly Ile Arg Leu Thr Ile Ala Glu Glu Arg Asp Lys Arg Leu Ala 
                 245                250                255
Ala Lys Gln Ser Ser Gly 
             260



<210> 9382
<211> 916
<212> DNA
<213> Homo sapiens
<308> NM_001007
<400> 9382

aagacggag  tcctctttc  ttgcctaac  cagccatgg  tcgtggtcc  aagaagcat  60
tgaagcggg  ggcagctcc  aagcattgg  tgctggata  attgaccgg  gtgtttgct  120
ctcgtccat  caccggtcc  cacaagttg  gagagtgtc  ccccctcat  attttcctg  180
ggaacagac  taagtatgc  ctgacagga  atgaagtaa  gaagatttg  atgcagcgg  240
tcattaaaa  cgatggcaa  gtccgaact  atataacct  ccctgctgg  ttcatggat  300
tcatcagca  tgacaagac  ggagagaat  tccgtctga  ctatgacac  aagggtcgc  360
ttgctgtac  tcgtattac  cctgaggag  ccaagtaca  gttgtgcaa  gtgagaaag  420
tctttgtgg  cacaaaagg  atccctcat  tggtgactc  tgatgcccg  accatccgc  480
accccgatc  cctcatcaa  gtgaatgat  ccattcaga  tgatttgga  actggcaag  540
ttactgatt  catcaagtt  gacactggt  acctgtgta  ggtgactgg  ggtgctaac  600
taggaagaa  tggtgtgat  accaacaga  agaggcacc  tggatcttt  gacgtggtt  660
acgtgaaag  tgccaatgg  aacagcttt  ccactcgac  ttccaacat  tttgttatt  720
gcaagggca  caaaccatg  atttctctt  cccgaggaa  gggtatccg  ctcaccatt  780
ctgaagaga  agacaaaag  ctggcggcc  aacagagca  tgggtgaaa  gggtccctg  840
gtgacatgt  agatctttg  acgtaatta  aaatattgt  gcaggatta  tagcaaaaa  900
aaaaaaaaa  aaaaaa  916



<210> 9383
<211> 262
<212> PRT
<213> Homo sapiens
<308> P12750
<400> 9383

Ala Arg Gly Pro Lys Lys His Leu Lys Arg Val Ala Ala Pro Lys His 
  1               5                  10                  15
Trp Met Leu Asp Lys Leu Thr Gly Val Phe Ala Pro Arg Pro Ser Thr 
             20                  25                  30
Gly Pro His Lys Leu Arg Glu Cys Leu Pro Leu Ile Ile Phe Leu Arg 
         35                  40                  45
Asn Arg Leu Lys Tyr Ala Leu Thr Gly Asp Glu Val Lys Lys Ile Cys 
     50                  55                  60
Met Gln Arg Phe Ile Lys Ile Asp Gly Lys Val Arg Thr Asp Ile Thr 
 65                  70                  75                  80
Tyr Pro Ala Gly Phe Met Asp Val Ile Ser Ile Asp Lys Thr Gly Glu 
                 85                  90                  95
Asn Phe Arg Leu Ile Tyr Asp Thr Lys Gly Arg Phe Ala Val His Arg 
             100                105                110
Ile Thr Pro Glu Glu Ala Lys Tyr Lys Leu Cys Lys Val Arg Lys Ile 
         115                120                125
Phe Val Gly Thr Lys Gly Ile Pro His Leu Val Thr His Asp Ala Arg 
     130                135                140
Thr Ile Arg Tyr Pro Asp Pro Leu Ile Lys Val Asn Asp Thr Ile Gln 
 145                150                155                160
Ile Asp Leu Glu Thr Gly Lys Ile Thr Asp Phe Ile Lys Phe Asp Thr 
                 165                170                175
Gly Asn Leu Cys Met Val Thr Gly Gly Ala Asn Leu Gly Arg Ile Gly 
             180                185                190
Val Ile Thr Asn Arg Glu Arg His Pro Gly Ser Phe Asp Val Val His 
         195                200                205
Val Lys Asp Ala Asn Gly Asn Ser Phe Ala Thr Arg Leu Ser Asn Ile 
     210                215                220
Phe Val Ile Gly Lys Gly Asn Lys Pro Trp Ile Ser Leu Pro Arg Gly 
 225                230                235                240
Lys Gly Ile Arg Leu Thr Ile Ala Glu Glu Arg Asp Lys Arg Leu Ala 
                 245                250                255
Ala Lys Gln Ser Ser Gly 
             260



<210> 9384
<211> 907
<212> DNA
<213> Rattus norvegicus
<308> X14210
<400> 9384

tctttccgt  cccagcgca  catggctcg  ggtcccaag  aacatctga  gcgcgtagc  60
gctccaaaa  actggatgc  ggataagct  actggcgtg  ttgctcctc  tccatccac  120
ggtccacac  aactgaggg  atgcctgcc  ctgatcatt  tcctaagga  cagacttaa  180
tatgccctg  ctggagatg  agtaaaaaa  atttgcatg  agcgattca  taagattga  240
gggaaagtc  ggaccgata  aacctaccc  gctgggttt  tggatgtca  cagcattga  300
aagactgga  agaacttcc  tctgatcta  gacaccaag  gtcgctttg  tgtccatcg  360
attacacct  aggaggcca  gtacaagtt  tgcaaagtg  gaaagatct  tgtgggcac  420
aaaggaatc  cacatctgg  gacccatga  gcccgtact  ttcgatacc  tgatcccct  480
atcaaggtg  atgacacca  tcagattga  ttggaaaca  gcaagataa  tgatttcat  540
aagttcgac  ctgggaacc  gtgtatggt  actggaggt  ctaacttgg  gagaattgg  600
gtaatcacc  atagggaga  acatcctgg  tcttttgat  tggttcatg  gaaagatgc  660
aacggcaac  gctttgcca  tcgtctttc  aacattttt  ttattggca  gggcaacaa  720
ccgtggatt  ctcttcccc  aggaaaagg  atccgcctt  ccattgctg  agagagaga  780
aagaggcta  cagccaaac  gagcagtgg  tgaaatggt  tctaggaga  atgctggag  840
agtatttgt  cctcaacac  acaagcctt  ctaagcaac  tgctagatt  aacagcatg  900
tgaaatc  907



<210> 9385
<211> 262
<212> PRT
<213> Rattus norvegicus
<308> CAA32427
<400> 9385

Ala Arg Gly Pro Lys Lys His Leu Lys Arg Val Ala Ala Pro Lys His 
  1               5                  10                  15
Trp Met Leu Asp Lys Leu Thr Gly Val Phe Ala Pro Arg Pro Ser Thr 
             20                  25                  30
Gly Pro His Lys Leu Arg Glu Cys Leu Pro Leu Ile Ile Phe Leu Arg 
         35                  40                  45
Asn Arg Leu Lys Tyr Ala Leu Thr Gly Asp Glu Val Lys Lys Ile Cys 
     50                  55                  60
Met Gln Arg Phe Ile Lys Ile Asp Gly Lys Val Arg Thr Asp Ile Thr 
 65                  70                  75                  80
Tyr Pro Ala Gly Phe Met Asp Val Ile Ser Ile Asp Lys Thr Gly Glu 
                 85                  90                  95
Asn Phe Arg Leu Ile Tyr Asp Thr Lys Gly Arg Phe Ala Val His Arg 
             100                105                110
Ile Thr Pro Glu Glu Ala Lys Tyr Lys Leu Cys Lys Val Arg Lys Ile 
         115                120                125
Phe Val Gly Thr Lys Gly Ile Pro His Leu Val Thr His Asp Ala Arg 
     130                135                140
Thr Ile Arg Tyr Pro Asp Pro Leu Ile Lys Val Asn Asp Thr Ile Gln 
 145                150                155                160
Ile Asp Leu Glu Thr Gly Lys Ile Thr Asp Phe Ile Lys Phe Asp Thr 
                 165                170                175
Gly Asn Leu Cys Met Val Thr Gly Gly Ala Asn Leu Gly Arg Ile Gly 
             180                185                190
Val Ile Thr Asn Arg Glu Arg His Pro Gly Ser Phe Asp Val Val His 
         195                200                205
Val Lys Asp Ala Asn Gly Asn Ser Phe Ala Thr Arg Leu Ser Asn Ile 
     210                215                220
Phe Val Ile Gly Lys Gly Asn Lys Pro Trp Ile Ser Leu Pro Arg Gly 
 225                230                235                240
Lys Gly Ile Arg Leu Thr Ile Ala Glu Glu Arg Asp Lys Arg Leu Ala 
                 245                250                255
Ala Lys Gln Ser Ser Gly 
             260



<210> 9386
<211> 916
<212> DNA
<213> Homo sapiens
<308> NM_001007
<400> 9386

aagacggag  tcctctttc  ttgcctaac  cagccatgg  tcgtggtcc  aagaagcat  60
tgaagcggg  ggcagctcc  aagcattgg  tgctggata  attgaccgg  gtgtttgct  120
ctcgtccat  caccggtcc  cacaagttg  gagagtgtc  ccccctcat  attttcctg  180
ggaacagac  taagtatgc  ctgacagga  atgaagtaa  gaagatttg  atgcagcgg  240
tcattaaaa  cgatggcaa  gtccgaact  atataacct  ccctgctgg  ttcatggat  300
tcatcagca  tgacaagac  ggagagaat  tccgtctga  ctatgacac  aagggtcgc  360
ttgctgtac  tcgtattac  cctgaggag  ccaagtaca  gttgtgcaa  gtgagaaag  420
tctttgtgg  cacaaaagg  atccctcat  tggtgactc  tgatgcccg  accatccgc  480
accccgatc  cctcatcaa  gtgaatgat  ccattcaga  tgatttgga  actggcaag  540
ttactgatt  catcaagtt  gacactggt  acctgtgta  ggtgactgg  ggtgctaac  600
taggaagaa  tggtgtgat  accaacaga  agaggcacc  tggatcttt  gacgtggtt  660
acgtgaaag  tgccaatgg  aacagcttt  ccactcgac  ttccaacat  tttgttatt  720
gcaagggca  caaaccatg  atttctctt  cccgaggaa  gggtatccg  ctcaccatt  780
ctgaagaga  agacaaaag  ctggcggcc  aacagagca  tgggtgaaa  gggtccctg  840
gtgacatgt  agatctttg  acgtaatta  aaatattgt  gcaggatta  tagcaaaaa  900
aaaaaaaaa  aaaaaa  916



<210> 9387
<211> 262
<212> PRT
<213> Homo sapiens
<308> P12750
<400> 9387

Ala Arg Gly Pro Lys Lys His Leu Lys Arg Val Ala Ala Pro Lys His 
  1               5                  10                  15
Trp Met Leu Asp Lys Leu Thr Gly Val Phe Ala Pro Arg Pro Ser Thr 
             20                  25                  30
Gly Pro His Lys Leu Arg Glu Cys Leu Pro Leu Ile Ile Phe Leu Arg 
         35                  40                  45
Asn Arg Leu Lys Tyr Ala Leu Thr Gly Asp Glu Val Lys Lys Ile Cys 
     50                  55                  60
Met Gln Arg Phe Ile Lys Ile Asp Gly Lys Val Arg Thr Asp Ile Thr 
 65                  70                  75                  80
Tyr Pro Ala Gly Phe Met Asp Val Ile Ser Ile Asp Lys Thr Gly Glu 
                 85                  90                  95
Asn Phe Arg Leu Ile Tyr Asp Thr Lys Gly Arg Phe Ala Val His Arg 
             100                105                110
Ile Thr Pro Glu Glu Ala Lys Tyr Lys Leu Cys Lys Val Arg Lys Ile 
         115                120                125
Phe Val Gly Thr Lys Gly Ile Pro His Leu Val Thr His Asp Ala Arg 
     130                135                140
Thr Ile Arg Tyr Pro Asp Pro Leu Ile Lys Val Asn Asp Thr Ile Gln 
 145                150                155                160
Ile Asp Leu Glu Thr Gly Lys Ile Thr Asp Phe Ile Lys Phe Asp Thr 
                 165                170                175
Gly Asn Leu Cys Met Val Thr Gly Gly Ala Asn Leu Gly Arg Ile Gly 
             180                185                190
Val Ile Thr Asn Arg Glu Arg His Pro Gly Ser Phe Asp Val Val His 
         195                200                205
Val Lys Asp Ala Asn Gly Asn Ser Phe Ala Thr Arg Leu Ser Asn Ile 
     210                215                220
Phe Val Ile Gly Lys Gly Asn Lys Pro Trp Ile Ser Leu Pro Arg Gly 
 225                230                235                240
Lys Gly Ile Arg Leu Thr Ile Ala Glu Glu Arg Asp Lys Arg Leu Ala 
                 245                250                255
Ala Lys Gln Ser Ser Gly 
             260



<210> 9388
<211> 907
<212> DNA
<213> Rattus norvegicus
<308> X14210
<400> 9388

tctttccgt  cccagcgca  catggctcg  ggtcccaag  aacatctga  gcgcgtagc  60
gctccaaaa  actggatgc  ggataagct  actggcgtg  ttgctcctc  tccatccac  120
ggtccacac  aactgaggg  atgcctgcc  ctgatcatt  tcctaagga  cagacttaa  180
tatgccctg  ctggagatg  agtaaaaaa  atttgcatg  agcgattca  taagattga  240
gggaaagtc  ggaccgata  aacctaccc  gctgggttt  tggatgtca  cagcattga  300
aagactgga  agaacttcc  tctgatcta  gacaccaag  gtcgctttg  tgtccatcg  360
attacacct  aggaggcca  gtacaagtt  tgcaaagtg  gaaagatct  tgtgggcac  420
aaaggaatc  cacatctgg  gacccatga  gcccgtact  ttcgatacc  tgatcccct  480
atcaaggtg  atgacacca  tcagattga  ttggaaaca  gcaagataa  tgatttcat  540
aagttcgac  ctgggaacc  gtgtatggt  actggaggt  ctaacttgg  gagaattgg  600
gtaatcacc  atagggaga  acatcctgg  tcttttgat  tggttcatg  gaaagatgc  660
aacggcaac  gctttgcca  tcgtctttc  aacattttt  ttattggca  gggcaacaa  720
ccgtggatt  ctcttcccc  aggaaaagg  atccgcctt  ccattgctg  agagagaga  780
aagaggcta  cagccaaac  gagcagtgg  tgaaatggt  tctaggaga  atgctggag  840
agtatttgt  cctcaacac  acaagcctt  ctaagcaac  tgctagatt  aacagcatg  900
tgaaatc  907



<210> 9389
<211> 262
<212> PRT
<213> Rattus norvegicus
<308> CAA32427
<400> 9389

Ala Arg Gly Pro Lys Lys His Leu Lys Arg Val Ala Ala Pro Lys His 
  1               5                  10                  15
Trp Met Leu Asp Lys Leu Thr Gly Val Phe Ala Pro Arg Pro Ser Thr 
             20                  25                  30
Gly Pro His Lys Leu Arg Glu Cys Leu Pro Leu Ile Ile Phe Leu Arg 
         35                  40                  45
Asn Arg Leu Lys Tyr Ala Leu Thr Gly Asp Glu Val Lys Lys Ile Cys 
     50                  55                  60
Met Gln Arg Phe Ile Lys Ile Asp Gly Lys Val Arg Thr Asp Ile Thr 
 65                  70                  75                  80
Tyr Pro Ala Gly Phe Met Asp Val Ile Ser Ile Asp Lys Thr Gly Glu 
                 85                  90                  95
Asn Phe Arg Leu Ile Tyr Asp Thr Lys Gly Arg Phe Ala Val His Arg 
             100                105                110
Ile Thr Pro Glu Glu Ala Lys Tyr Lys Leu Cys Lys Val Arg Lys Ile 
         115                120                125
Phe Val Gly Thr Lys Gly Ile Pro His Leu Val Thr His Asp Ala Arg 
     130                135                140
Thr Ile Arg Tyr Pro Asp Pro Leu Ile Lys Val Asn Asp Thr Ile Gln 
 145                150                155                160
Ile Asp Leu Glu Thr Gly Lys Ile Thr Asp Phe Ile Lys Phe Asp Thr 
                 165                170                175
Gly Asn Leu Cys Met Val Thr Gly Gly Ala Asn Leu Gly Arg Ile Gly 
             180                185                190
Val Ile Thr Asn Arg Glu Arg His Pro Gly Ser Phe Asp Val Val His 
         195                200                205
Val Lys Asp Ala Asn Gly Asn Ser Phe Ala Thr Arg Leu Ser Asn Ile 
     210                215                220
Phe Val Ile Gly Lys Gly Asn Lys Pro Trp Ile Ser Leu Pro Arg Gly 
 225                230                235                240
Lys Gly Ile Arg Leu Thr Ile Ala Glu Glu Arg Asp Lys Arg Leu Ala 
                 245                250                255
Ala Lys Gln Ser Ser Gly 
             260



<210> 9390
<211> 916
<212> DNA
<213> Homo sapiens
<308> NM_001007
<400> 9390

aagacggag  tcctctttc  ttgcctaac  cagccatgg  tcgtggtcc  aagaagcat  60
tgaagcggg  ggcagctcc  aagcattgg  tgctggata  attgaccgg  gtgtttgct  120
ctcgtccat  caccggtcc  cacaagttg  gagagtgtc  ccccctcat  attttcctg  180
ggaacagac  taagtatgc  ctgacagga  atgaagtaa  gaagatttg  atgcagcgg  240
tcattaaaa  cgatggcaa  gtccgaact  atataacct  ccctgctgg  ttcatggat  300
tcatcagca  tgacaagac  ggagagaat  tccgtctga  ctatgacac  aagggtcgc  360
ttgctgtac  tcgtattac  cctgaggag  ccaagtaca  gttgtgcaa  gtgagaaag  420
tctttgtgg  cacaaaagg  atccctcat  tggtgactc  tgatgcccg  accatccgc  480
accccgatc  cctcatcaa  gtgaatgat  ccattcaga  tgatttgga  actggcaag  540
ttactgatt  catcaagtt  gacactggt  acctgtgta  ggtgactgg  ggtgctaac  600
taggaagaa  tggtgtgat  accaacaga  agaggcacc  tggatcttt  gacgtggtt  660
acgtgaaag  tgccaatgg  aacagcttt  ccactcgac  ttccaacat  tttgttatt  720
gcaagggca  caaaccatg  atttctctt  cccgaggaa  gggtatccg  ctcaccatt  780
ctgaagaga  agacaaaag  ctggcggcc  aacagagca  tgggtgaaa  gggtccctg  840
gtgacatgt  agatctttg  acgtaatta  aaatattgt  gcaggatta  tagcaaaaa  900
aaaaaaaaa  aaaaaa  916



<210> 9391
<211> 262
<212> PRT
<213> Homo sapiens
<308> P12750
<400> 9391

Ala Arg Gly Pro Lys Lys His Leu Lys Arg Val Ala Ala Pro Lys His 
  1               5                  10                  15
Trp Met Leu Asp Lys Leu Thr Gly Val Phe Ala Pro Arg Pro Ser Thr 
             20                  25                  30
Gly Pro His Lys Leu Arg Glu Cys Leu Pro Leu Ile Ile Phe Leu Arg 
         35                  40                  45
Asn Arg Leu Lys Tyr Ala Leu Thr Gly Asp Glu Val Lys Lys Ile Cys 
     50                  55                  60
Met Gln Arg Phe Ile Lys Ile Asp Gly Lys Val Arg Thr Asp Ile Thr 
 65                  70                  75                  80
Tyr Pro Ala Gly Phe Met Asp Val Ile Ser Ile Asp Lys Thr Gly Glu 
                 85                  90                  95
Asn Phe Arg Leu Ile Tyr Asp Thr Lys Gly Arg Phe Ala Val His Arg 
             100                105                110
Ile Thr Pro Glu Glu Ala Lys Tyr Lys Leu Cys Lys Val Arg Lys Ile 
         115                120                125
Phe Val Gly Thr Lys Gly Ile Pro His Leu Val Thr His Asp Ala Arg 
     130                135                140
Thr Ile Arg Tyr Pro Asp Pro Leu Ile Lys Val Asn Asp Thr Ile Gln 
 145                150                155                160
Ile Asp Leu Glu Thr Gly Lys Ile Thr Asp Phe Ile Lys Phe Asp Thr 
                 165                170                175
Gly Asn Leu Cys Met Val Thr Gly Gly Ala Asn Leu Gly Arg Ile Gly 
             180                185                190
Val Ile Thr Asn Arg Glu Arg His Pro Gly Ser Phe Asp Val Val His 
         195                200                205
Val Lys Asp Ala Asn Gly Asn Ser Phe Ala Thr Arg Leu Ser Asn Ile 
     210                215                220
Phe Val Ile Gly Lys Gly Asn Lys Pro Trp Ile Ser Leu Pro Arg Gly 
 225                230                235                240
Lys Gly Ile Arg Leu Thr Ile Ala Glu Glu Arg Asp Lys Arg Leu Ala 
                 245                250                255
Ala Lys Gln Ser Ser Gly 
             260



<210> 9392
<211> 907
<212> DNA
<213> Rattus norvegicus
<308> X14210
<400> 9392

tctttccgt  cccagcgca  catggctcg  ggtcccaag  aacatctga  gcgcgtagc  60
gctccaaaa  actggatgc  ggataagct  actggcgtg  ttgctcctc  tccatccac  120
ggtccacac  aactgaggg  atgcctgcc  ctgatcatt  tcctaagga  cagacttaa  180
tatgccctg  ctggagatg  agtaaaaaa  atttgcatg  agcgattca  taagattga  240
gggaaagtc  ggaccgata  aacctaccc  gctgggttt  tggatgtca  cagcattga  300
aagactgga  agaacttcc  tctgatcta  gacaccaag  gtcgctttg  tgtccatcg  360
attacacct  aggaggcca  gtacaagtt  tgcaaagtg  gaaagatct  tgtgggcac  420
aaaggaatc  cacatctgg  gacccatga  gcccgtact  ttcgatacc  tgatcccct  480
atcaaggtg  atgacacca  tcagattga  ttggaaaca  gcaagataa  tgatttcat  540
aagttcgac  ctgggaacc  gtgtatggt  actggaggt  ctaacttgg  gagaattgg  600
gtaatcacc  atagggaga  acatcctgg  tcttttgat  tggttcatg  gaaagatgc  660
aacggcaac  gctttgcca  tcgtctttc  aacattttt  ttattggca  gggcaacaa  720
ccgtggatt  ctcttcccc  aggaaaagg  atccgcctt  ccattgctg  agagagaga  780
aagaggcta  cagccaaac  gagcagtgg  tgaaatggt  tctaggaga  atgctggag  840
agtatttgt  cctcaacac  acaagcctt  ctaagcaac  tgctagatt  aacagcatg  900
tgaaatc  907



<210> 9393
<211> 262
<212> PRT
<213> Rattus norvegicus
<308> CAA32427
<400> 9393

Ala Arg Gly Pro Lys Lys His Leu Lys Arg Val Ala Ala Pro Lys His 
  1               5                  10                  15
Trp Met Leu Asp Lys Leu Thr Gly Val Phe Ala Pro Arg Pro Ser Thr 
             20                  25                  30
Gly Pro His Lys Leu Arg Glu Cys Leu Pro Leu Ile Ile Phe Leu Arg 
         35                  40                  45
Asn Arg Leu Lys Tyr Ala Leu Thr Gly Asp Glu Val Lys Lys Ile Cys 
     50                  55                  60
Met Gln Arg Phe Ile Lys Ile Asp Gly Lys Val Arg Thr Asp Ile Thr 
 65                  70                  75                  80
Tyr Pro Ala Gly Phe Met Asp Val Ile Ser Ile Asp Lys Thr Gly Glu 
                 85                  90                  95
Asn Phe Arg Leu Ile Tyr Asp Thr Lys Gly Arg Phe Ala Val His Arg 
             100                105                110
Ile Thr Pro Glu Glu Ala Lys Tyr Lys Leu Cys Lys Val Arg Lys Ile 
         115                120                125
Phe Val Gly Thr Lys Gly Ile Pro His Leu Val Thr His Asp Ala Arg 
     130                135                140
Thr Ile Arg Tyr Pro Asp Pro Leu Ile Lys Val Asn Asp Thr Ile Gln 
 145                150                155                160
Ile Asp Leu Glu Thr Gly Lys Ile Thr Asp Phe Ile Lys Phe Asp Thr 
                 165                170                175
Gly Asn Leu Cys Met Val Thr Gly Gly Ala Asn Leu Gly Arg Ile Gly 
             180                185                190
Val Ile Thr Asn Arg Glu Arg His Pro Gly Ser Phe Asp Val Val His 
         195                200                205
Val Lys Asp Ala Asn Gly Asn Ser Phe Ala Thr Arg Leu Ser Asn Ile 
     210                215                220
Phe Val Ile Gly Lys Gly Asn Lys Pro Trp Ile Ser Leu Pro Arg Gly 
 225                230                235                240
Lys Gly Ile Arg Leu Thr Ile Ala Glu Glu Arg Asp Lys Arg Leu Ala 
                 245                250                255
Ala Lys Gln Ser Ser Gly 
             260



<210> 9394
<211> 916
<212> DNA
<213> Homo sapiens
<308> NM_001007
<400> 9394

aagacggag  tcctctttc  ttgcctaac  cagccatgg  tcgtggtcc  aagaagcat  60
tgaagcggg  ggcagctcc  aagcattgg  tgctggata  attgaccgg  gtgtttgct  120
ctcgtccat  caccggtcc  cacaagttg  gagagtgtc  ccccctcat  attttcctg  180
ggaacagac  taagtatgc  ctgacagga  atgaagtaa  gaagatttg  atgcagcgg  240
tcattaaaa  cgatggcaa  gtccgaact  atataacct  ccctgctgg  ttcatggat  300
tcatcagca  tgacaagac  ggagagaat  tccgtctga  ctatgacac  aagggtcgc  360
ttgctgtac  tcgtattac  cctgaggag  ccaagtaca  gttgtgcaa  gtgagaaag  420
tctttgtgg  cacaaaagg  atccctcat  tggtgactc  tgatgcccg  accatccgc  480
accccgatc  cctcatcaa  gtgaatgat  ccattcaga  tgatttgga  actggcaag  540
ttactgatt  catcaagtt  gacactggt  acctgtgta  ggtgactgg  ggtgctaac  600
taggaagaa  tggtgtgat  accaacaga  agaggcacc  tggatcttt  gacgtggtt  660
acgtgaaag  tgccaatgg  aacagcttt  ccactcgac  ttccaacat  tttgttatt  720
gcaagggca  caaaccatg  atttctctt  cccgaggaa  gggtatccg  ctcaccatt  780
ctgaagaga  agacaaaag  ctggcggcc  aacagagca  tgggtgaaa  gggtccctg  840
gtgacatgt  agatctttg  acgtaatta  aaatattgt  gcaggatta  tagcaaaaa  900
aaaaaaaaa  aaaaaa  916



<210> 9395
<211> 262
<212> PRT
<213> Homo sapiens
<308> P12750
<400> 9395

Ala Arg Gly Pro Lys Lys His Leu Lys Arg Val Ala Ala Pro Lys His 
  1               5                  10                  15
Trp Met Leu Asp Lys Leu Thr Gly Val Phe Ala Pro Arg Pro Ser Thr 
             20                  25                  30
Gly Pro His Lys Leu Arg Glu Cys Leu Pro Leu Ile Ile Phe Leu Arg 
         35                  40                  45
Asn Arg Leu Lys Tyr Ala Leu Thr Gly Asp Glu Val Lys Lys Ile Cys 
     50                  55                  60
Met Gln Arg Phe Ile Lys Ile Asp Gly Lys Val Arg Thr Asp Ile Thr 
 65                  70                  75                  80
Tyr Pro Ala Gly Phe Met Asp Val Ile Ser Ile Asp Lys Thr Gly Glu 
                 85                  90                  95
Asn Phe Arg Leu Ile Tyr Asp Thr Lys Gly Arg Phe Ala Val His Arg 
             100                105                110
Ile Thr Pro Glu Glu Ala Lys Tyr Lys Leu Cys Lys Val Arg Lys Ile 
         115                120                125
Phe Val Gly Thr Lys Gly Ile Pro His Leu Val Thr His Asp Ala Arg 
     130                135                140
Thr Ile Arg Tyr Pro Asp Pro Leu Ile Lys Val Asn Asp Thr Ile Gln 
 145                150                155                160
Ile Asp Leu Glu Thr Gly Lys Ile Thr Asp Phe Ile Lys Phe Asp Thr 
                 165                170                175
Gly Asn Leu Cys Met Val Thr Gly Gly Ala Asn Leu Gly Arg Ile Gly 
             180                185                190
Val Ile Thr Asn Arg Glu Arg His Pro Gly Ser Phe Asp Val Val His 
         195                200                205
Val Lys Asp Ala Asn Gly Asn Ser Phe Ala Thr Arg Leu Ser Asn Ile 
     210                215                220
Phe Val Ile Gly Lys Gly Asn Lys Pro Trp Ile Ser Leu Pro Arg Gly 
 225                230                235                240
Lys Gly Ile Arg Leu Thr Ile Ala Glu Glu Arg Asp Lys Arg Leu Ala 
                 245                250                255
Ala Lys Gln Ser Ser Gly 
             260



<210> 9396
<211> 1353
<212> DNA
<213> Rattus norvegicus
<308> X14254
<400> 9396

cagcagcag  agcagcagc  gcaccagca  cacttgggg  aaaagctag  ggctagagt  60
atggatgac  agcgcgacc  catctctaa  catgagcag  tgcccatcc  gggccagcg  120
gctagagcc  cagaaagca  ttgcaaccg  ggagtcctg  acaccagtg  ctctgtcct  180
gtggctctg  tcttggctg  gcaggccac  actgcttac  tcctgtacc  gcagcaggg  240
cgcctggac  agctgaccg  cacctccca  aacctgcaa  tggagaacc  tcgcatgaa  300
cttccgaaa  ctgccaaac  tgtgagccc  atgcgcatg  ctactccct  gctgatgcg  360
ccactgtcc  tggataaca  gctccaagc  cccgtgaag  atgttacca  gtatggcaa  420
atgacccag  accacgtga  gcacctgct  acgaagtct  gacccgtga  ctacccaca  480
ctgaagggg  gcttcccgg  gaatctgaa  caccttaag  actctatga  tggtctgga  540
tggaaggtc  ttgagagct  gatgaaaca  tggctgttg  ttgaaatga  caagaactc  600
ctggaggag  agcagccca  ccagactcc  cctaaagta  tgaccaagt  ccaggaaga  660
gtcagccac  tccctgatg  ccacccggg  gcgttccgt  ccaagtgtg  tgagaacgg  720
aactatatg  cactccagt  ccatgggag  actggctac  gctggtgtg  gttccccaa  780
ggcactgag  tccctcaca  caagagccg  gggcgccat  actgcagtg  gccactgga  840
atggaagac  catcttctg  cctgggagt  accaagcag  atatgggcc  aatgttctt  900
tgaagacag  agccagctc  gcacggcgg  agctcccct  ctcctcagc  cttcttaca  960
tccctaaca  cacacccca  ttcccgtct  cctgcaccc  ggggcttga  actggtatc  1020
gcttcaccg  ccctggaca  aacaaatga  accggaaca  aatgagaac  ctggaggga  1080
ggccttgct  cctaccccc  tctaaggga  ccccatttc  gacccatta  cagtcttta  1140
tgtggggct  tgagatcta  gcccactga  agggatagg  gatgcccta  ccttaatct  1200
ggctggata  atttgctgt  ttctcaagg  agaggccaa  ccctcccag  aacccttcc  1260
catgtcctg  cgacgcccc  gggatccct  ctcagccaa  cttgtcagc  gcctgtagg  1320
ccatggttc  cgtgacaat  aaaggtaga  ggt  1353



<210> 9397
<211> 280
<212> PRT
<213> Rattus norvegicus
<308> CAA32468
<400> 9397

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
  1               5                  10                  15
Leu Gly Gln Arg Ala Arg Ala Pro Glu Ser Asn Cys Asn Arg Gly Val 
             20                  25                  30
Leu Tyr Thr Ser Val Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln 
         35                  40                  45
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
     50                  55                  60
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
 65                  70                  75                  80
Leu Pro Lys Ser Ala Lys Pro Val Ser Pro Met Arg Met Ala Thr Pro 
                 85                  90                  95
Leu Leu Met Arg Pro Leu Ser Met Asp Asn Met Leu Gln Ala Pro Val 
             100                105                110
Lys Asn Val Thr Lys Tyr Gly Asn Met Thr Gln Asp His Val Met His 
         115                120                125
Leu Leu Thr Lys Ser Gly Pro Val Asn Tyr Pro Gln Leu Lys Gly Ser 
     130                135                140
Phe Pro Glu Asn Leu Lys His Leu Lys Asn Ser Met Asn Gly Leu Asp 
 145                150                155                160
Trp Lys Val Phe Glu Ser Trp Met Lys Gln Trp Leu Leu Phe Glu Met 
                 165                170                175
Ser Lys Asn Ser Leu Glu Glu Lys Gln Pro Thr Gln Thr Pro Pro Lys 
             180                185                190
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Asp Val His 
         195                200                205
Pro Gly Ala Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Met Pro 
     210                215                220
Leu Gln Cys His Gly Ser Thr Gly Tyr Cys Trp Cys Val Phe Pro Asn 
 225                230                235                240
Gly Thr Glu Val Pro His Thr Lys Ser Arg Gly Arg His Asn Cys Ser 
                 245                250                255
Glu Pro Leu Asp Met Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
             260                265                270
Gln Asp Met Gly Gln Met Phe Leu 
         275                280



<210> 9398
<211> 1287
<212> DNA
<213> Homo sapiens
<308> K01144
<400> 9398

ctgcagggg  ggggggggg  gggggggac  ttggctctt  cttggggag  gatgcacag  60
aggagaagc  ggagctgtc  ggaagatca  aagccagtc  tggatgacc  gcgcgacct  120
atctccaac  atgagcaac  gcccatgct  ggccggcgc  ctggggccc  ggagagcaa  180
tgcagccgc  gagccctgt  cacaggctt  tccatcctg  tgactctgc  cctcgctgg  240
caggccacc  ccgcctact  cctgtacca  cagcagggc  ggctggaca  actgacagt  300
acctcccag  acctgcagc  ggagaacct  cgcatgaag  ttcccaagc  tcccaagcc  360
gtgagcaag  tgcgcatgg  caccccgct  ctgatgcag  cgctgccca  gggagccct  420
ccccagggg  ccatgcaga  tgccaccaa  tatggcaac  tgacagagg  ccatgtgat  480
cacctgctc  agaatgctg  ccccctgaa  gtgtacccg  cactgaagg  gagcttccc  540
gagaacctg  gacacctta  gaacaccat  gagaccata  actggaagg  ctttgagag  600
tggatgcac  attggctcc  gtttgaaat  agcaggcac  ccttggagc  aaagcccac  660
gacgctcca  cgaaagagt  actggaact  gaggacccg  cttctgggc  gggtgtgac  720
aagcaggat  tgggcccag  ccccatgtg  gagcagcag  ggcggtctt  aacatcctg  780
cagccccac  cagctacag  tttcttgct  ccttcagcc  ccagcccct  ccccatctc  840
caccctgta  ctcatccca  gagaccctg  tgcctggct  tttcgtcac  cttggacaa  900
acaaaccaa  tcggaacag  agataacaa  gcagcaagg  cctgctgcc  aatctccat  960
tgtcaacag  ggcgtgagg  cccaggaag  ggccaaaag  tagacagat  cccgttcct  1020
acatcacag  agcctccaa  acaaggctc  aagacctag  ctcatggac  agatgggaa  1080
gcacaggga  aagggataa  cctacaccc  gaccccagg  tggacatgc  gactgtcct  1140
tcccctcca  cctttggcc  tggcttttc  agcctattt  cctgcaggc  gagccactc  1200
cttcccttt  cccagcatc  ctccccaag  aagagccaa  gttttccac  catccctcc  1260
ccccccccc  ccccccccc  cctgcag  1287



<210> 9399
<211> 296
<212> PRT
<213> Homo sapiens
<308> P04233
<400> 9399

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
  1               5                  10                  15
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
             20                  25                  30
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
         35                  40                  45
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
     50                  55                  60
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
 65                  70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                 85                  90                  95
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
             100                105                110
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
         115                120                125
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
     130                135                140
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
 145                150                155                160
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                 165                170                175
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
             180                185                190
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
         195                200                205
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
     210                215                220
Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
 225                230                235                240
Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                 245                250                255
Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
             260                265                270
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
         275                280                285
Gln Asp Leu Gly Pro Val Pro Met 
     290                295



<210> 9400
<211> 1353
<212> DNA
<213> Rattus norvegicus
<308> X14254
<400> 9400

cagcagcag  agcagcagc  gcaccagca  cacttgggg  aaaagctag  ggctagagt  60
atggatgac  agcgcgacc  catctctaa  catgagcag  tgcccatcc  gggccagcg  120
gctagagcc  cagaaagca  ttgcaaccg  ggagtcctg  acaccagtg  ctctgtcct  180
gtggctctg  tcttggctg  gcaggccac  actgcttac  tcctgtacc  gcagcaggg  240
cgcctggac  agctgaccg  cacctccca  aacctgcaa  tggagaacc  tcgcatgaa  300
cttccgaaa  ctgccaaac  tgtgagccc  atgcgcatg  ctactccct  gctgatgcg  360
ccactgtcc  tggataaca  gctccaagc  cccgtgaag  atgttacca  gtatggcaa  420
atgacccag  accacgtga  gcacctgct  acgaagtct  gacccgtga  ctacccaca  480
ctgaagggg  gcttcccgg  gaatctgaa  caccttaag  actctatga  tggtctgga  540
tggaaggtc  ttgagagct  gatgaaaca  tggctgttg  ttgaaatga  caagaactc  600
ctggaggag  agcagccca  ccagactcc  cctaaagta  tgaccaagt  ccaggaaga  660
gtcagccac  tccctgatg  ccacccggg  gcgttccgt  ccaagtgtg  tgagaacgg  720
aactatatg  cactccagt  ccatgggag  actggctac  gctggtgtg  gttccccaa  780
ggcactgag  tccctcaca  caagagccg  gggcgccat  actgcagtg  gccactgga  840
atggaagac  catcttctg  cctgggagt  accaagcag  atatgggcc  aatgttctt  900
tgaagacag  agccagctc  gcacggcgg  agctcccct  ctcctcagc  cttcttaca  960
tccctaaca  cacacccca  ttcccgtct  cctgcaccc  ggggcttga  actggtatc  1020
gcttcaccg  ccctggaca  aacaaatga  accggaaca  aatgagaac  ctggaggga  1080
ggccttgct  cctaccccc  tctaaggga  ccccatttc  gacccatta  cagtcttta  1140
tgtggggct  tgagatcta  gcccactga  agggatagg  gatgcccta  ccttaatct  1200
ggctggata  atttgctgt  ttctcaagg  agaggccaa  ccctcccag  aacccttcc  1260
catgtcctg  cgacgcccc  gggatccct  ctcagccaa  cttgtcagc  gcctgtagg  1320
ccatggttc  cgtgacaat  aaaggtaga  ggt  1353



<210> 9401
<211> 280
<212> PRT
<213> Rattus norvegicus
<308> CAA32468
<400> 9401

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
  1               5                  10                  15
Leu Gly Gln Arg Ala Arg Ala Pro Glu Ser Asn Cys Asn Arg Gly Val 
             20                  25                  30
Leu Tyr Thr Ser Val Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln 
         35                  40                  45
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
     50                  55                  60
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
 65                  70                  75                  80
Leu Pro Lys Ser Ala Lys Pro Val Ser Pro Met Arg Met Ala Thr Pro 
                 85                  90                  95
Leu Leu Met Arg Pro Leu Ser Met Asp Asn Met Leu Gln Ala Pro Val 
             100                105                110
Lys Asn Val Thr Lys Tyr Gly Asn Met Thr Gln Asp His Val Met His 
         115                120                125
Leu Leu Thr Lys Ser Gly Pro Val Asn Tyr Pro Gln Leu Lys Gly Ser 
     130                135                140
Phe Pro Glu Asn Leu Lys His Leu Lys Asn Ser Met Asn Gly Leu Asp 
 145                150                155                160
Trp Lys Val Phe Glu Ser Trp Met Lys Gln Trp Leu Leu Phe Glu Met 
                 165                170                175
Ser Lys Asn Ser Leu Glu Glu Lys Gln Pro Thr Gln Thr Pro Pro Lys 
             180                185                190
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Asp Val His 
         195                200                205
Pro Gly Ala Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Met Pro 
     210                215                220
Leu Gln Cys His Gly Ser Thr Gly Tyr Cys Trp Cys Val Phe Pro Asn 
 225                230                235                240
Gly Thr Glu Val Pro His Thr Lys Ser Arg Gly Arg His Asn Cys Ser 
                 245                250                255
Glu Pro Leu Asp Met Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
             260                265                270
Gln Asp Met Gly Gln Met Phe Leu 
         275                280



<210> 9402
<211> 1287
<212> DNA
<213> Homo sapiens
<308> K01144
<400> 9402

ctgcagggg  ggggggggg  gggggggac  ttggctctt  cttggggag  gatgcacag  60
aggagaagc  ggagctgtc  ggaagatca  aagccagtc  tggatgacc  gcgcgacct  120
atctccaac  atgagcaac  gcccatgct  ggccggcgc  ctggggccc  ggagagcaa  180
tgcagccgc  gagccctgt  cacaggctt  tccatcctg  tgactctgc  cctcgctgg  240
caggccacc  ccgcctact  cctgtacca  cagcagggc  ggctggaca  actgacagt  300
acctcccag  acctgcagc  ggagaacct  cgcatgaag  ttcccaagc  tcccaagcc  360
gtgagcaag  tgcgcatgg  caccccgct  ctgatgcag  cgctgccca  gggagccct  420
ccccagggg  ccatgcaga  tgccaccaa  tatggcaac  tgacagagg  ccatgtgat  480
cacctgctc  agaatgctg  ccccctgaa  gtgtacccg  cactgaagg  gagcttccc  540
gagaacctg  gacacctta  gaacaccat  gagaccata  actggaagg  ctttgagag  600
tggatgcac  attggctcc  gtttgaaat  agcaggcac  ccttggagc  aaagcccac  660
gacgctcca  cgaaagagt  actggaact  gaggacccg  cttctgggc  gggtgtgac  720
aagcaggat  tgggcccag  ccccatgtg  gagcagcag  ggcggtctt  aacatcctg  780
cagccccac  cagctacag  tttcttgct  ccttcagcc  ccagcccct  ccccatctc  840
caccctgta  ctcatccca  gagaccctg  tgcctggct  tttcgtcac  cttggacaa  900
acaaaccaa  tcggaacag  agataacaa  gcagcaagg  cctgctgcc  aatctccat  960
tgtcaacag  ggcgtgagg  cccaggaag  ggccaaaag  tagacagat  cccgttcct  1020
acatcacag  agcctccaa  acaaggctc  aagacctag  ctcatggac  agatgggaa  1080
gcacaggga  aagggataa  cctacaccc  gaccccagg  tggacatgc  gactgtcct  1140
tcccctcca  cctttggcc  tggcttttc  agcctattt  cctgcaggc  gagccactc  1200
cttcccttt  cccagcatc  ctccccaag  aagagccaa  gttttccac  catccctcc  1260
ccccccccc  ccccccccc  cctgcag  1287



<210> 9403
<211> 296
<212> PRT
<213> Homo sapiens
<308> P04233
<400> 9403

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
  1               5                  10                  15
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
             20                  25                  30
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
         35                  40                  45
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
     50                  55                  60
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
 65                  70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                 85                  90                  95
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
             100                105                110
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
         115                120                125
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
     130                135                140
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
 145                150                155                160
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                 165                170                175
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
             180                185                190
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
         195                200                205
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
     210                215                220
Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
 225                230                235                240
Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                 245                250                255
Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
             260                265                270
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
         275                280                285
Gln Asp Leu Gly Pro Val Pro Met 
     290                295



<210> 9404
<211> 1552
<212> DNA
<213> Rattus norvegicus
<308> X14323
<400> 9404

tcagttctg  aattaatta  ctaacgtgg  tcaaatgag  aggtgaaag  tcacacagg  60
gcactcctg  cgtcttgga  tgggtctcc  tcccaccat  cagtgccct  gtctacgaa  120
agtccacag  gaccttgtg  agaatcaac  aggcggggt  cagaggagt  acgtgtgcc  180
tccactccg  gtcgccctg  caggatggg  atgtcccag  ccggggtcc  cctcagcct  240
ttattggtc  tcctgcctc  gacctgggg  gcggagccc  gtctcccac  gatgtatca  300
cttgcagct  tgtctgact  atcaacggg  cttccctct  tctgggcca  gggctggct  360
ggtgctcag  aatatctga  ctacaacaa  ctgcggcag  aggctgacc  ctgtggggc  420
tggatatgg  aaaaccagg  gtcttggta  tgggagaag  agaccacgg  tctgaaaag  480
aaagaacag  tcttcttgg  ggccatcag  accctggag  accaaataa  tgggacctt  540
acactgcag  gcctgctgg  ctgtgaact  gcccctgat  attcttcat  gcccacggc  600
gtgtttgcc  tcaatggtg  ggagttcat  cggttcaac  caagaacgg  caactggag  660
ggggagtgg  cggagacag  tatcgttgg  aatctgtgg  tgaagcaac  tgaggcggc  720
aggaaggag  gcgagttcc  gctaacttc  tgtcctgag  ggctgctag  ccacctgga  780
aggggccgt  agaacctgg  gtggaagga  ccgccatct  tgcgcctga  ggcccgtcc  840
ggcaactct  gctcctcag  actgacctg  gctgctttc  ccttctacc  gccggagct  900
aagtttcga  tcctgcgca  tgggctagc  tcaggctct  ggaattgca  cactggtcc  960
aatggtgat  gatctttcc  tgcatggtc  ttgctagag  tcaaacgtg  agatgaaca  1020
cattaccaa  gtcaagtgg  gcatgaggg  ctggcccag  ctctcactg  ggacctaga  1080
tcgcccgcc  gatcttctg  gcctgtggt  ggaatcatt  ttggtttat  gctggtggt  1140
gtggccatc  cagggggtg  gctgctatg  aacaggatg  gaagtgggc  gccagcccc  1200
tggctttct  tcagtggtg  tgactctgg  gacctattg  ctggtggga  cttgccccc  1260
gaggctgaa  ctcaaggtg  aaatgcctt  ccggccact  cctgatgcc  acccaggcc  1320
catacccat  gcagcctgt  gggctgtgt  acctcctga  ctgtctctg  gcctcccga  1380
ggagccctg  gctggatgt  ctcctcgtg  atcccttct  ttgtggcct  cttcagttt  1440
ccctcttaa  gtcaatggc  atttccatc  ccacataaa  ttgggccca  atctgtgtg  1500
gcatcgtta  tctcaggtt  caggcagcc  gaataaatt  aacaagttt  ag  1552



<210> 9405
<211> 366
<212> PRT
<213> Rattus norvegicus
<308> CAA32503
<400> 9405

Met Gly Met Ser Gln Pro Gly Val Leu Leu Ser Leu Leu Leu Val Leu 
  1               5                  10                  15
Leu Pro Gln Thr Trp Gly Ala Glu Pro Arg Leu Pro Leu Met Tyr His 
             20                  25                  30
Leu Ala Ala Val Ser Asp Leu Ser Thr Gly Leu Pro Ser Phe Trp Ala 
         35                  40                  45
Thr Gly Trp Leu Gly Ala Gln Gln Tyr Leu Thr Tyr Asn Asn Leu Arg 
     50                  55                  60
Gln Glu Ala Asp Pro Cys Gly Ala Trp Ile Trp Glu Asn Gln Val Ser 
 65                  70                  75                  80
Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Lys Ser Lys Glu Gln Leu 
                 85                  90                  95
Phe Leu Glu Ala Ile Arg Thr Leu Glu Asn Gln Ile Asn Gly Thr Phe 
             100                105                110
Thr Leu Gln Gly Leu Leu Gly Cys Glu Leu Ala Pro Asp Asn Ser Ser 
         115                120                125
Leu Pro Thr Ala Val Phe Ala Leu Asn Gly Glu Glu Phe Met Arg Phe 
     130                135                140
Asn Pro Arg Thr Gly Asn Trp Ser Gly Glu Trp Pro Glu Thr Asp Ile 
 145                150                155                160
Val Gly Asn Leu Trp Met Lys Gln Pro Glu Ala Ala Arg Lys Glu Ser 
                 165                170                175
Glu Phe Leu Leu Thr Ser Cys Pro Glu Arg Leu Leu Gly His Leu Glu 
             180                185                190
Arg Gly Arg Gln Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu 
         195                200                205
Lys Ala Arg Pro Gly Asn Ser Gly Ser Ser Val Leu Thr Cys Ala Ala 
     210                215                220
Phe Ser Phe Tyr Pro Pro Glu Leu Lys Phe Arg Phe Leu Arg Asn Gly 
 225                230                235                240
Leu Ala Ser Gly Ser Gly Asn Cys Ser Thr Gly Pro Asn Gly Asp Gly 
                 245                250                255
Ser Phe His Ala Trp Ser Leu Leu Glu Val Lys Arg Gly Asp Glu His 
             260                265                270
His Tyr Gln Cys Gln Val Glu His Glu Gly Leu Ala Gln Pro Leu Thr 
         275                280                285
Val Asp Leu Asp Ser Pro Ala Arg Ser Ser Val Pro Val Val Gly Ile 
     290                295                300
Ile Leu Gly Leu Leu Leu Val Val Val Ala Ile Ala Gly Gly Val Leu 
 305                310                315                320
Leu Trp Asn Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Leu Ser Leu 
                 325                330                335
Ser Gly Asp Asp Ser Gly Asp Leu Leu Pro Gly Gly Asn Leu Pro Pro 
             340                345                350
Glu Ala Glu Pro Gln Gly Val Asn Ala Phe Pro Ala Thr Ser 
         355                360                365



<210> 9407
<211> 365
<212> PRT
<213> Homo sapiens
<308> P55899
<400> 9407

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
  1               5                  10                  15
Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
             20                  25                  30
His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
         35                  40                  45
Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
     50                  55                  60
Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
 65                  70                  75                  80
Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                 85                  90                  95
Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
             100                105                110
Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
         115                120                125
Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
     130                135                140
Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
 145                150                155                160
Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                 165                170                175
Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
             180                185                190
Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
         195                200                205
Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
     210                215                220
Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
 225                230                235                240
Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                 245                250                255
Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
             260                265                270
Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
         275                280                285
Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
     290                295                300
Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
 305                310                315                320
Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                 325                330                335
Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
             340                345                350
Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
         355                360                365



<210> 9408
<211> 1552
<212> DNA
<213> Rattus norvegicus
<308> X14323
<400> 9408

tcagttctg  aattaatta  ctaacgtgg  tcaaatgag  aggtgaaag  tcacacagg  60
gcactcctg  cgtcttgga  tgggtctcc  tcccaccat  cagtgccct  gtctacgaa  120
agtccacag  gaccttgtg  agaatcaac  aggcggggt  cagaggagt  acgtgtgcc  180
tccactccg  gtcgccctg  caggatggg  atgtcccag  ccggggtcc  cctcagcct  240
ttattggtc  tcctgcctc  gacctgggg  gcggagccc  gtctcccac  gatgtatca  300
cttgcagct  tgtctgact  atcaacggg  cttccctct  tctgggcca  gggctggct  360
ggtgctcag  aatatctga  ctacaacaa  ctgcggcag  aggctgacc  ctgtggggc  420
tggatatgg  aaaaccagg  gtcttggta  tgggagaag  agaccacgg  tctgaaaag  480
aaagaacag  tcttcttgg  ggccatcag  accctggag  accaaataa  tgggacctt  540
acactgcag  gcctgctgg  ctgtgaact  gcccctgat  attcttcat  gcccacggc  600
gtgtttgcc  tcaatggtg  ggagttcat  cggttcaac  caagaacgg  caactggag  660
ggggagtgg  cggagacag  tatcgttgg  aatctgtgg  tgaagcaac  tgaggcggc  720
aggaaggag  gcgagttcc  gctaacttc  tgtcctgag  ggctgctag  ccacctgga  780
aggggccgt  agaacctgg  gtggaagga  ccgccatct  tgcgcctga  ggcccgtcc  840
ggcaactct  gctcctcag  actgacctg  gctgctttc  ccttctacc  gccggagct  900
aagtttcga  tcctgcgca  tgggctagc  tcaggctct  ggaattgca  cactggtcc  960
aatggtgat  gatctttcc  tgcatggtc  ttgctagag  tcaaacgtg  agatgaaca  1020
cattaccaa  gtcaagtgg  gcatgaggg  ctggcccag  ctctcactg  ggacctaga  1080
tcgcccgcc  gatcttctg  gcctgtggt  ggaatcatt  ttggtttat  gctggtggt  1140
gtggccatc  cagggggtg  gctgctatg  aacaggatg  gaagtgggc  gccagcccc  1200
tggctttct  tcagtggtg  tgactctgg  gacctattg  ctggtggga  cttgccccc  1260
gaggctgaa  ctcaaggtg  aaatgcctt  ccggccact  cctgatgcc  acccaggcc  1320
catacccat  gcagcctgt  gggctgtgt  acctcctga  ctgtctctg  gcctcccga  1380
ggagccctg  gctggatgt  ctcctcgtg  atcccttct  ttgtggcct  cttcagttt  1440
ccctcttaa  gtcaatggc  atttccatc  ccacataaa  ttgggccca  atctgtgtg  1500
gcatcgtta  tctcaggtt  caggcagcc  gaataaatt  aacaagttt  ag  1552



<210> 9409
<211> 366
<212> PRT
<213> Rattus norvegicus
<308> CAA32503
<400> 9409

Met Gly Met Ser Gln Pro Gly Val Leu Leu Ser Leu Leu Leu Val Leu 
  1               5                  10                  15
Leu Pro Gln Thr Trp Gly Ala Glu Pro Arg Leu Pro Leu Met Tyr His 
             20                  25                  30
Leu Ala Ala Val Ser Asp Leu Ser Thr Gly Leu Pro Ser Phe Trp Ala 
         35                  40                  45
Thr Gly Trp Leu Gly Ala Gln Gln Tyr Leu Thr Tyr Asn Asn Leu Arg 
     50                  55                  60
Gln Glu Ala Asp Pro Cys Gly Ala Trp Ile Trp Glu Asn Gln Val Ser 
 65                  70                  75                  80
Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Lys Ser Lys Glu Gln Leu 
                 85                  90                  95
Phe Leu Glu Ala Ile Arg Thr Leu Glu Asn Gln Ile Asn Gly Thr Phe 
             100                105                110
Thr Leu Gln Gly Leu Leu Gly Cys Glu Leu Ala Pro Asp Asn Ser Ser 
         115                120                125
Leu Pro Thr Ala Val Phe Ala Leu Asn Gly Glu Glu Phe Met Arg Phe 
     130                135                140
Asn Pro Arg Thr Gly Asn Trp Ser Gly Glu Trp Pro Glu Thr Asp Ile 
 145                150                155                160
Val Gly Asn Leu Trp Met Lys Gln Pro Glu Ala Ala Arg Lys Glu Ser 
                 165                170                175
Glu Phe Leu Leu Thr Ser Cys Pro Glu Arg Leu Leu Gly His Leu Glu 
             180                185                190
Arg Gly Arg Gln Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu 
         195                200                205
Lys Ala Arg Pro Gly Asn Ser Gly Ser Ser Val Leu Thr Cys Ala Ala 
     210                215                220
Phe Ser Phe Tyr Pro Pro Glu Leu Lys Phe Arg Phe Leu Arg Asn Gly 
 225                230                235                240
Leu Ala Ser Gly Ser Gly Asn Cys Ser Thr Gly Pro Asn Gly Asp Gly 
                 245                250                255
Ser Phe His Ala Trp Ser Leu Leu Glu Val Lys Arg Gly Asp Glu His 
             260                265                270
His Tyr Gln Cys Gln Val Glu His Glu Gly Leu Ala Gln Pro Leu Thr 
         275                280                285
Val Asp Leu Asp Ser Pro Ala Arg Ser Ser Val Pro Val Val Gly Ile 
     290                295                300
Ile Leu Gly Leu Leu Leu Val Val Val Ala Ile Ala Gly Gly Val Leu 
 305                310                315                320
Leu Trp Asn Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Leu Ser Leu 
                 325                330                335
Ser Gly Asp Asp Ser Gly Asp Leu Leu Pro Gly Gly Asn Leu Pro Pro 
             340                345                350
Glu Ala Glu Pro Gln Gly Val Asn Ala Phe Pro Ala Thr Ser 
         355                360                365



<210> 9411
<211> 365
<212> PRT
<213> Homo sapiens
<308> P55899
<400> 9411

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
  1               5                  10                  15
Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
             20                  25                  30
His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
         35                  40                  45
Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
     50                  55                  60
Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
 65                  70                  75                  80
Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                 85                  90                  95
Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
             100                105                110
Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
         115                120                125
Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
     130                135                140
Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
 145                150                155                160
Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                 165                170                175
Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
             180                185                190
Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
         195                200                205
Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
     210                215                220
Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
 225                230                235                240
Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                 245                250                255
Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
             260                265                270
Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
         275                280                285
Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
     290                295                300
Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
 305                310                315                320
Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                 325                330                335
Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
             340                345                350
Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
         355                360                365



<210> 9412
<211> 1552
<212> DNA
<213> Rattus norvegicus
<308> X14323
<400> 9412

tcagttctg  aattaatta  ctaacgtgg  tcaaatgag  aggtgaaag  tcacacagg  60
gcactcctg  cgtcttgga  tgggtctcc  tcccaccat  cagtgccct  gtctacgaa  120
agtccacag  gaccttgtg  agaatcaac  aggcggggt  cagaggagt  acgtgtgcc  180
tccactccg  gtcgccctg  caggatggg  atgtcccag  ccggggtcc  cctcagcct  240
ttattggtc  tcctgcctc  gacctgggg  gcggagccc  gtctcccac  gatgtatca  300
cttgcagct  tgtctgact  atcaacggg  cttccctct  tctgggcca  gggctggct  360
ggtgctcag  aatatctga  ctacaacaa  ctgcggcag  aggctgacc  ctgtggggc  420
tggatatgg  aaaaccagg  gtcttggta  tgggagaag  agaccacgg  tctgaaaag  480
aaagaacag  tcttcttgg  ggccatcag  accctggag  accaaataa  tgggacctt  540
acactgcag  gcctgctgg  ctgtgaact  gcccctgat  attcttcat  gcccacggc  600
gtgtttgcc  tcaatggtg  ggagttcat  cggttcaac  caagaacgg  caactggag  660
ggggagtgg  cggagacag  tatcgttgg  aatctgtgg  tgaagcaac  tgaggcggc  720
aggaaggag  gcgagttcc  gctaacttc  tgtcctgag  ggctgctag  ccacctgga  780
aggggccgt  agaacctgg  gtggaagga  ccgccatct  tgcgcctga  ggcccgtcc  840
ggcaactct  gctcctcag  actgacctg  gctgctttc  ccttctacc  gccggagct  900
aagtttcga  tcctgcgca  tgggctagc  tcaggctct  ggaattgca  cactggtcc  960
aatggtgat  gatctttcc  tgcatggtc  ttgctagag  tcaaacgtg  agatgaaca  1020
cattaccaa  gtcaagtgg  gcatgaggg  ctggcccag  ctctcactg  ggacctaga  1080
tcgcccgcc  gatcttctg  gcctgtggt  ggaatcatt  ttggtttat  gctggtggt  1140
gtggccatc  cagggggtg  gctgctatg  aacaggatg  gaagtgggc  gccagcccc  1200
tggctttct  tcagtggtg  tgactctgg  gacctattg  ctggtggga  cttgccccc  1260
gaggctgaa  ctcaaggtg  aaatgcctt  ccggccact  cctgatgcc  acccaggcc  1320
catacccat  gcagcctgt  gggctgtgt  acctcctga  ctgtctctg  gcctcccga  1380
ggagccctg  gctggatgt  ctcctcgtg  atcccttct  ttgtggcct  cttcagttt  1440
ccctcttaa  gtcaatggc  atttccatc  ccacataaa  ttgggccca  atctgtgtg  1500
gcatcgtta  tctcaggtt  caggcagcc  gaataaatt  aacaagttt  ag  1552



<210> 9413
<211> 366
<212> PRT
<213> Rattus norvegicus
<308> CAA32503
<400> 9413

Met Gly Met Ser Gln Pro Gly Val Leu Leu Ser Leu Leu Leu Val Leu 
  1               5                  10                  15
Leu Pro Gln Thr Trp Gly Ala Glu Pro Arg Leu Pro Leu Met Tyr His 
             20                  25                  30
Leu Ala Ala Val Ser Asp Leu Ser Thr Gly Leu Pro Ser Phe Trp Ala 
         35                  40                  45
Thr Gly Trp Leu Gly Ala Gln Gln Tyr Leu Thr Tyr Asn Asn Leu Arg 
     50                  55                  60
Gln Glu Ala Asp Pro Cys Gly Ala Trp Ile Trp Glu Asn Gln Val Ser 
 65                  70                  75                  80
Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Lys Ser Lys Glu Gln Leu 
                 85                  90                  95
Phe Leu Glu Ala Ile Arg Thr Leu Glu Asn Gln Ile Asn Gly Thr Phe 
             100                105                110
Thr Leu Gln Gly Leu Leu Gly Cys Glu Leu Ala Pro Asp Asn Ser Ser 
         115                120                125
Leu Pro Thr Ala Val Phe Ala Leu Asn Gly Glu Glu Phe Met Arg Phe 
     130                135                140
Asn Pro Arg Thr Gly Asn Trp Ser Gly Glu Trp Pro Glu Thr Asp Ile 
 145                150                155                160
Val Gly Asn Leu Trp Met Lys Gln Pro Glu Ala Ala Arg Lys Glu Ser 
                 165                170                175
Glu Phe Leu Leu Thr Ser Cys Pro Glu Arg Leu Leu Gly His Leu Glu 
             180                185                190
Arg Gly Arg Gln Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu 
         195                200                205
Lys Ala Arg Pro Gly Asn Ser Gly Ser Ser Val Leu Thr Cys Ala Ala 
     210                215                220
Phe Ser Phe Tyr Pro Pro Glu Leu Lys Phe Arg Phe Leu Arg Asn Gly 
 225                230                235                240
Leu Ala Ser Gly Ser Gly Asn Cys Ser Thr Gly Pro Asn Gly Asp Gly 
                 245                250                255
Ser Phe His Ala Trp Ser Leu Leu Glu Val Lys Arg Gly Asp Glu His 
             260                265                270
His Tyr Gln Cys Gln Val Glu His Glu Gly Leu Ala Gln Pro Leu Thr 
         275                280                285
Val Asp Leu Asp Ser Pro Ala Arg Ser Ser Val Pro Val Val Gly Ile 
     290                295                300
Ile Leu Gly Leu Leu Leu Val Val Val Ala Ile Ala Gly Gly Val Leu 
 305                310                315                320
Leu Trp Asn Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Leu Ser Leu 
                 325                330                335
Ser Gly Asp Asp Ser Gly Asp Leu Leu Pro Gly Gly Asn Leu Pro Pro 
             340                345                350
Glu Ala Glu Pro Gln Gly Val Asn Ala Phe Pro Ala Thr Ser 
         355                360                365



<210> 9415
<211> 365
<212> PRT
<213> Homo sapiens
<308> P55899
<400> 9415

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
  1               5                  10                  15
Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
             20                  25                  30
His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
         35                  40                  45
Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
     50                  55                  60
Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
 65                  70                  75                  80
Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                 85                  90                  95
Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
             100                105                110
Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
         115                120                125
Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
     130                135                140
Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
 145                150                155                160
Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                 165                170                175
Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
             180                185                190
Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
         195                200                205
Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
     210                215                220
Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
 225                230                235                240
Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                 245                250                255
Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
             260                265                270
Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
         275                280                285
Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
     290                295                300
Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
 305                310                315                320
Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                 325                330                335
Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
             340                345                350
Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
         355                360                365



<210> 9416
<211> 1552
<212> DNA
<213> Rattus norvegicus
<308> X14323
<400> 9416

tcagttctg  aattaatta  ctaacgtgg  tcaaatgag  aggtgaaag  tcacacagg  60
gcactcctg  cgtcttgga  tgggtctcc  tcccaccat  cagtgccct  gtctacgaa  120
agtccacag  gaccttgtg  agaatcaac  aggcggggt  cagaggagt  acgtgtgcc  180
tccactccg  gtcgccctg  caggatggg  atgtcccag  ccggggtcc  cctcagcct  240
ttattggtc  tcctgcctc  gacctgggg  gcggagccc  gtctcccac  gatgtatca  300
cttgcagct  tgtctgact  atcaacggg  cttccctct  tctgggcca  gggctggct  360
ggtgctcag  aatatctga  ctacaacaa  ctgcggcag  aggctgacc  ctgtggggc  420
tggatatgg  aaaaccagg  gtcttggta  tgggagaag  agaccacgg  tctgaaaag  480
aaagaacag  tcttcttgg  ggccatcag  accctggag  accaaataa  tgggacctt  540
acactgcag  gcctgctgg  ctgtgaact  gcccctgat  attcttcat  gcccacggc  600
gtgtttgcc  tcaatggtg  ggagttcat  cggttcaac  caagaacgg  caactggag  660
ggggagtgg  cggagacag  tatcgttgg  aatctgtgg  tgaagcaac  tgaggcggc  720
aggaaggag  gcgagttcc  gctaacttc  tgtcctgag  ggctgctag  ccacctgga  780
aggggccgt  agaacctgg  gtggaagga  ccgccatct  tgcgcctga  ggcccgtcc  840
ggcaactct  gctcctcag  actgacctg  gctgctttc  ccttctacc  gccggagct  900
aagtttcga  tcctgcgca  tgggctagc  tcaggctct  ggaattgca  cactggtcc  960
aatggtgat  gatctttcc  tgcatggtc  ttgctagag  tcaaacgtg  agatgaaca  1020
cattaccaa  gtcaagtgg  gcatgaggg  ctggcccag  ctctcactg  ggacctaga  1080
tcgcccgcc  gatcttctg  gcctgtggt  ggaatcatt  ttggtttat  gctggtggt  1140
gtggccatc  cagggggtg  gctgctatg  aacaggatg  gaagtgggc  gccagcccc  1200
tggctttct  tcagtggtg  tgactctgg  gacctattg  ctggtggga  cttgccccc  1260
gaggctgaa  ctcaaggtg  aaatgcctt  ccggccact  cctgatgcc  acccaggcc  1320
catacccat  gcagcctgt  gggctgtgt  acctcctga  ctgtctctg  gcctcccga  1380
ggagccctg  gctggatgt  ctcctcgtg  atcccttct  ttgtggcct  cttcagttt  1440
ccctcttaa  gtcaatggc  atttccatc  ccacataaa  ttgggccca  atctgtgtg  1500
gcatcgtta  tctcaggtt  caggcagcc  gaataaatt  aacaagttt  ag  1552



<210> 9417
<211> 366
<212> PRT
<213> Rattus norvegicus
<308> CAA32503
<400> 9417

Met Gly Met Ser Gln Pro Gly Val Leu Leu Ser Leu Leu Leu Val Leu 
  1               5                  10                  15
Leu Pro Gln Thr Trp Gly Ala Glu Pro Arg Leu Pro Leu Met Tyr His 
             20                  25                  30
Leu Ala Ala Val Ser Asp Leu Ser Thr Gly Leu Pro Ser Phe Trp Ala 
         35                  40                  45
Thr Gly Trp Leu Gly Ala Gln Gln Tyr Leu Thr Tyr Asn Asn Leu Arg 
     50                  55                  60
Gln Glu Ala Asp Pro Cys Gly Ala Trp Ile Trp Glu Asn Gln Val Ser 
 65                  70                  75                  80
Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Lys Ser Lys Glu Gln Leu 
                 85                  90                  95
Phe Leu Glu Ala Ile Arg Thr Leu Glu Asn Gln Ile Asn Gly Thr Phe 
             100                105                110
Thr Leu Gln Gly Leu Leu Gly Cys Glu Leu Ala Pro Asp Asn Ser Ser 
         115                120                125
Leu Pro Thr Ala Val Phe Ala Leu Asn Gly Glu Glu Phe Met Arg Phe 
     130                135                140
Asn Pro Arg Thr Gly Asn Trp Ser Gly Glu Trp Pro Glu Thr Asp Ile 
 145                150                155                160
Val Gly Asn Leu Trp Met Lys Gln Pro Glu Ala Ala Arg Lys Glu Ser 
                 165                170                175
Glu Phe Leu Leu Thr Ser Cys Pro Glu Arg Leu Leu Gly His Leu Glu 
             180                185                190
Arg Gly Arg Gln Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu 
         195                200                205
Lys Ala Arg Pro Gly Asn Ser Gly Ser Ser Val Leu Thr Cys Ala Ala 
     210                215                220
Phe Ser Phe Tyr Pro Pro Glu Leu Lys Phe Arg Phe Leu Arg Asn Gly 
 225                230                235                240
Leu Ala Ser Gly Ser Gly Asn Cys Ser Thr Gly Pro Asn Gly Asp Gly 
                 245                250                255
Ser Phe His Ala Trp Ser Leu Leu Glu Val Lys Arg Gly Asp Glu His 
             260                265                270
His Tyr Gln Cys Gln Val Glu His Glu Gly Leu Ala Gln Pro Leu Thr 
         275                280                285
Val Asp Leu Asp Ser Pro Ala Arg Ser Ser Val Pro Val Val Gly Ile 
     290                295                300
Ile Leu Gly Leu Leu Leu Val Val Val Ala Ile Ala Gly Gly Val Leu 
 305                310                315                320
Leu Trp Asn Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Leu Ser Leu 
                 325                330                335
Ser Gly Asp Asp Ser Gly Asp Leu Leu Pro Gly Gly Asn Leu Pro Pro 
             340                345                350
Glu Ala Glu Pro Gln Gly Val Asn Ala Phe Pro Ala Thr Ser 
         355                360                365



<210> 9419
<211> 365
<212> PRT
<213> Homo sapiens
<308> P55899
<400> 9419

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
  1               5                  10                  15
Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
             20                  25                  30
His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
         35                  40                  45
Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
     50                  55                  60
Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
 65                  70                  75                  80
Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                 85                  90                  95
Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
             100                105                110
Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
         115                120                125
Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
     130                135                140
Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
 145                150                155                160
Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                 165                170                175
Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
             180                185                190
Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
         195                200                205
Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
     210                215                220
Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
 225                230                235                240
Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                 245                250                255
Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
             260                265                270
Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
         275                280                285
Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
     290                295                300
Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
 305                310                315                320
Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                 325                330                335
Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
             340                345                350
Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
         355                360                365



<210> 9420
<211> 508
<212> DNA
<213> Rattus norvegicus
<308> X14671
<400> 9420

tccttttgc  gccatcgct  gattgcagc  gccaaaatg  agttcaatc  cttcgtgac  60
tctgaccga  gcaagaacc  caaacggca  ttcaatgca  catctcaca  tcggaggaa  120
atcatgtct  ctccgcttt  caaagaact  agacagaag  ataatgttc  gtctatgcc  180
attcgaaag  acgacgaag  tcaggttgt  cgaggacac  acaaaggcc  gcagattgg  240
aaagtggtc  aagtgtaca  gaagaaata  gtcatctac  ttgagcgag  ccagcgaga  300
aaggctaac  gcacaactg  ccatgtggg  atccgcccc  gcaaggtgg  tatcaccag  360
ctaaagctg  acaaggacc  caagaagat  ctggagagg  aagccaagt  ccggcaagt  420
ggaaaggag  agggcaaat  caaggaaga  actatcgag  agatgcagg  gtagaaaaa  480
aatgcccag  tttcattaa  taaagctt  508



<210> 9421
<211> 145
<212> PRT
<213> Rattus norvegicus
<308> CAA32801
<400> 9421

Met Lys Phe Asn Pro Phe Val Thr Ser Asp Arg Ser Lys Asn Arg Lys 
  1               5                  10                  15
Arg His Phe Asn Ala Pro Ser His Ile Arg Arg Lys Ile Met Ser Ser 
             20                  25                  30
Pro Leu Ser Lys Glu Leu Arg Gln Lys Tyr Asn Val Arg Ser Met Pro 
         35                  40                  45
Ile Arg Lys Asp Asp Glu Val Gln Val Val Arg Gly His Tyr Lys Gly 
     50                  55                  60
Gln Gln Ile Gly Lys Val Val Gln Val Tyr Arg Lys Lys Tyr Val Ile 
 65                  70                  75                  80
Tyr Ile Glu Arg Val Gln Arg Glu Lys Ala Asn Gly Thr Thr Val His 
                 85                  90                  95
Val Gly Ile Arg Pro Ser Lys Val Val Ile Thr Arg Leu Lys Leu Asp 
             100                105                110
Lys Asp Arg Lys Lys Ile Leu Glu Arg Lys Ala Lys Ser Arg Gln Val 
         115                120                125
Gly Lys Glu Lys Gly Lys Tyr Lys Glu Glu Thr Ile Glu Lys Met Gln 
     130                135                140
Glu 
 145



<210> 9422
<211> 16300
<212> DNA
<213> Rattus norvegicus
<308> X14848
<400> 9422

gttaatgta  cttataata  agcaaagca  tgaaaatgc  tagatggat  caaaaatcc  60
ataaacaca  aggtttggt  ctggcctta  aattaattg  aggtaagat  acacatgca  120
acatccata  accggtgta  aatccctta  agatttgcc  aaaacttaa  gagagggca  180
caagcacat  atatagctc  agacgcctt  cctagccac  cccccacgg  actcagcag  240
gataaatat  aagcaatga  cgaaagttt  actaagcta  tacctctca  ggttggtaa  300
tttcgtgcc  gccaccgcg  tcatacgat  aacccaaac  aattatttt  ggcgtaaaa  360
gtgccaact  taaatctca  aatagaatt  aaatccaac  tatatgtga  aattcattg  420
taggaccta  gcccaataa  gaaagtaat  ctaatcatt  atataatgc  cgatagcta  480
gacccaaac  gggattaga  accccacta  gcttagccc  aaaccttaa  aattaaacc  540
acaaaatta  ttgccagag  actactagc  acagcttaa  actcaaagg  cttggcggt  600
ctttatatc  atctagagg  gcctgttct  taatcgata  accccgttc  accttaccc  660
ttctcgcta  ttcagccta  ataccgcca  cttcagcaa  ccctaaaaa  gcactaaag  720
aagcacaag  acaaacata  aaacgttag  tcaaggtgt  gccaatgaa  cggaaagaa  780
tgggctaca  tttcttttc  cagagaaca  tacgaaacc  ttatgaaac  aaaggacaa  840
ggaggattt  gtagtaaat  aagaataga  agcttaatt  aatagagca  tgaagtacg  900
acacaccgc  cgtcaccct  ctcaaatta  attgacatt  acatataca  aatttcact  960
acaaattta  gagaggaga  aagtcgtaa  aaggtaagc  tactggaaa  tgtgcttgg  1020
ataatcaca  tgtagctta  tcacaaagc  tctggccta  acccagaag  attcataaa  1080
aatgaacac  ttgaactaa  cctagccct  caaccaacc  acataacta  acccccaca  1140
aaactaaaa  atttaactc  aaaagtatt  gagaaagaa  tttacttac  aagagctat  1200
gagaaagta  cgcaaggga  atgatgaaa  actaattta  agtaaaaac  agacaaaga  1260
taaacctgt  ccttttgca  aatgaatta  ctagaaaat  cttaacaaa  agaatttaa  1320
ctaagaacc  cgaaaccaa  cgagctacc  aaaaacaat  tcatgaatc  acccgtcta  1380
gtagcaaaa  agtgggaag  tttttaggt  gaggtgaaa  gcctatcga  cttggtgat  1440
gctggttgc  caaaaaaga  tttcagttc  aactttaag  ttccatcag  acaacaaat  1500
aaaatgtaa  cttaaaata  agccaaaag  gggacagct  tttaggaaa  ggaaaaaac  1560
ttaaatagt  aataaacaa  tacaatcac  taaccattg  aggcttaaa  gcaagccat  1620
aataaagaa  gcgtcaagc  acatcatct  acacacaca  taattccac  aacctcaaa  1680
attccaaaa  tacaaattg  gctaaatct  tgatcctag  gaatactgt  aatatgtga  1740
caagaacca  tccaccaag  acaagtgct  agacaaccg  ataaccatt  ttaattatt  1800
aatcatagg  ataacccaa  aatagaatt  cctatccct  actcgttag  ccaacacag  1860
cgtgcttta  ggaaagttt  aaaaagtaa  ggaactcgg  aaacacgaa  cccgcctgt  1920
taccaaaaa  atctcctct  gcataacaa  tattagtgg  atcgcctgc  cagtgacta  1980
agttccacg  ccgcggtat  ccgaccgtg  aaaggtagg  taatcactt  ttccttaat  2040
agggactag  atgaatggc  aaacgaggg  ccaaccgtc  cttacttgc  atcagtgaa  2100
ttgaccttc  agtgaaggg  cggactcat  ataaaagac  agaagaccc  atggagctt  2160
aatttacta  tttcaattt  tataaaaaa  cctaatggg  gaaaacaac  aaattatga  2220
ctaccaaat  tcggttggg  tgacctcgg  gaataaaaa  tcctccgaa  gattataac  2280
gagtcggta  ccgtgtccg  cccagtcaa  taatactaa  atcttattg  cccaattat  2340
gatcaacgg  ccaagttac  ctagggtaa  agcgcgacc  atttaagag  tcatatcga  2400
aattagggt  tacgacctc  atgttggat  aggacatcc  aatggtgca  aagctatta  2460
tggttcgtt  gttcaacga  taaagtcct  cgtgatcta  gtccggcaa  ccaggtcgg  2520
ttctatcta  ttacaattt  tcccagtta  gaaaggaca  gagaaatgg  gaccaacca  2580
tcctaggct  ccaaccaat  tagaaaaac  taataaagt  tatatgtac  ataaataac  2640
ttagaccca  gttattagg  tggcagagc  aagtaattg  gtaagactt  aaaccttgt  2700
cccagaggt  caaatcctc  ccctaatag  gtactttat  aatatccta  cactcctaa  2760
cccaatctt  attgccata  gccttctca  cctagtaga  cggaaaatc  taggctaca  2820
acaattacg  aaaggcccc  acaacgaag  cccatatgg  aaactacaa  catttgcag  2880
tgccataaa  ctattcata  aagaaccca  acgccctct  accacctca  tatcactat  2940
tattatcgc  ccaaccctc  cccttacac  agctctaag  ctatgaatt  ccttaccaa  3000
accccaccc  cttatcaac  tcaacctag  cataccatt  attctagcc  catccagcc  3060
ttcggtcta  tccattcta  gatcgggat  agcctcaaa  tcaaaatac  ccctattcg  3120
agccctacg  gccgttgcc  aaaccatct  ttacgaagt  acaatagcc  tatacctct  3180
atccgtcct  ctaataagc  gctccttct  cctacaaat  cttatcact  cacaagaac  3240
tatctgact  ttaatcccc  cctgaccaa  agccataat  tgatacatt  caaccctcg  3300
agaaacaaa  cgagctccc  tcgacttaa  agaaggaga  tcagaatta  tctcaggct  3360
taacgtcga  tacgccgca  gaccattcg  cctattctt  atagccgag  acaccaaca  3420
tattctaat  aacgcccta  catcaattg  attcctagg  cccttatat  atatcaatt  3480
ccctgaatt  tactcaacc  gcttcataa  agaaacact  cttctatcc  caactttcc  3540
atggattcg  gcatcctac  cccgttttc  atatgacca  ctaatgcac  tcctatgaa  3600
aaatttcct  ccactaaca  tagcattct  catatgata  atttccctg  caattttcc  3660
agcaggaat  ccaccctac  catagaaat  tgtctgaca  aagagttac  ttgatagag  3720
aaataatag  ggtttaaat  ctcttattt  taggacaat  ggaattgaa  ctacaccta  3780
gaattcaaa  ttctccgtg  caccaatac  ccctatcct  catagtaag  tcagctaac  3840
aagctatcg  gcccatacc  cgaaaatgt  ggttaaacc  ttcccgtac  aataaatcc  3900
attacccta  ccattattt  cttaaccac  tttaaaggc  gcctaatca  gacacttag  3960
accaactta  caccaatat  agtaggatt  gaaataagc  ttttagcta  catcccact  4020
ctagccaac  aaaaaagcc  acgatcaac  gaagcagca  caaaatatt  tctaaccca  4080
gctacagcc  caataatta  cctactagt  atcatcctc  actacaaac  atcaggaat  4140
tgaaccctt  aacaacaaa  caataacat  ctactcaac  taatactca  ttcactggc  4200
ataaaactt  gactagccc  attccacta  tgactaccc  aagtcaccc  aggaattcc  4260
ctacacatt  gattaatct  actaacatg  caaaaaatt  ctccactat  aattctata  4320
caattttat  aactcctaa  cccaactat  accaccatt  tcgcaattt  atcagtctt  4380
gttggcgcc  gaggaggac  taaccagac  caaacacga  aaatcatag  atactcatc  4440
attgcccac  taggatgaa  aacagcaat  cttccatac  accctaact  aaccctcct  4500
aacttaaca  tttacatcc  acttactgt  ccaatattc  attacatca  aacaaactc  4560
gcaacaaca  tcaacacac  ctcactcgc  tgaaataaa  ctcccataa  cctaaccat  4620
gcatccatc  tcctcctat  actaggagg  ctcccccct  tcacaggat  tttaccaaa  4680
tgagcaatt  tctccgagc  tctaaaaaa  aactgctca  ccctatcaa  actaatagc  4740
atcatagcc  tattaagcc  attcttcta  actcgacta  tttactcta  atccctcac  4800
acattccca  ccaacaaca  ctccaaaat  atctcccac  accaaaacc  aaaacataa  4860
tttatcctc  caaccctca  agtattaag  accctaacc  taccgcttt  ctcccaact  4920
atcacatag  agtttagga  atacagttc  agagccttc  aagccctta  aaaacaaac  4980
agtttaact  ctgataagg  ctgtaagac  atatcttac  tctgttaaa  gcaaatcaa  5040
tgctttaat  aagctaaat  ctcaactag  ttggaagga  tcaaattcc  acgaaaatt  5100
agttaacag  taaataccc  acttactgg  ttcaatcta  ttctcccgc  tatcagaaa  5160
gaggcggga  aagccttag  agaggagat  ctctacacc  tcgaacttg  aattcgaca  5220
gataatcac  ttaaggctt  ttggtaaaa  gggggctca  cccctgtct  tagatttac  5280
gtctaatgc  tactcagcc  ttttaccta  gttcgtaaa  cgttgactc  tttcaacta  5340
ccacaaaga  atcggaacc  tctacctat  atttggagc  tgagcagga  tagtaggga  5400
agctttgag  attctaatt  gagctgaac  aggacagcc  ggcgcactc  taggagatg  5460
ccaaatcta  aatgtcatc  tcacagccc  tgcattcgt  ataattttc  ttatagtaa  5520
acctataat  attggaggc  tcggaaact  acttgtacc  ctaataatt  gagcccctg  5580
tatagcatt  ccacgaata  ataacataa  cttttgact  cttcctcca  catttctac  5640
ccttttagc  tcctccata  tagaagctg  agctggaac  ggatgaaca  tatatcccc  5700
cttagccgg  aacctagcc  atgctgggg  atccgtaga  ttaactatt  tttccctcc  5760
cctagccgg  gtgtcttct  tcttaggag  tatcaactt  atcaccact  tcattaata  5820
aaaaccccc  gctataacc  aatatcaga  acctctctt  gtatgatcc  tactaatta  5880
agccgtcct  ctacttctc  cactgccag  attagcagc  ggtatcact  tactcctta  5940
agaccgaaa  ctaaatact  ctttcttcg  ccccgctgg  ggtggagac  caattcttt  6000
tcaacacct  ttctgattc  tcggccacc  agaagtgta  atcttaatt  ttccagggt  6060
tggaattat  tcacatgta  ttacctatt  ctctggaaa  aaagaaccc  tcggatata  6120
aggtatggt  tgaaccata  tatctattg  cttcctagg  tttattgta  gagcacatc  6180
catattcac  gtaggccta  atgtagaca  ccgagccta  tttacatct  ccactataa  6240
tatcgcaat  cctacaggc  taaaagtat  cagctgact  gctacacta  atggaggaa  6300
tatcaaatg  tcccccgcc  tattatgag  cttagggtt  atcttctta  tcacagtag  6360
gggcctaac  gggatcgta  tatctaact  atcccttga  attgtactt  atgatacat  6420
ctacgtagt  gctcacttc  actatgtct  atctatagg  gcagtattc  ccatcatag  6480
tggcttcgt  cactgattc  cactattct  aggctatac  ctaaatgac  catgagcaa  6540
agcccactt  gccattata  ttgtaggtg  aaacataac  ttttttcct  aacacttcc  6600
aggattagc  gggatacct  gtcgttact  tgattatcc  gatgcttat  ccacatgaa  6660
tacagtctc  tctataggc  cattcatct  acttacggc  gtccttgta  tgatcttca  6720
gatttgaga  gccttcgca  caaaacgag  agtgctctc  atttcctac  cttcaacta  6780
cctagaatg  ctgcatgga  gccccccac  ttaccacac  ttcgaagaa  cttcctatg  6840
aaaagttaa  taagaaagg  aggaatcga  cccctacaa  tggtttcaa  ccaatttca  6900
aaccattat  tctttctca  tgagatatt  gtaaaataa  tacataacc  tgtcaaggt  6960
aagttatag  cctaatcct  tatatctta  atggcttac  catttcaac  tggcttaca  7020
gacgctaca  cacctatca  agaagaact  acaaacttt  atgaccaca  cctaataat  7080
gtattcctc  tcagctccc  agtacttta  attatttca  taatactaa  aacaaaact  7140
acacacaca  gcacaatag  cgcccaaga  gtagaaaca  tttgaacaa  tctcccagc  7200
gtcattctt  ttctaattg  ccttccctc  ctacgaatt  tatacataa  agacgagat  7260
aataaccca  ttctaacag  aaaaactat  ggacaccaa  gatactgaa  ctatgaata  7320
actgactat  aagacctat  ctttgactc  tacataatc  caaccaatg  cctaaaacc  7380
ggtgaactt  gtctattag  agttgataa  cgggtagtc  taccaatag  acttccaat  7440
cgtatacta  tctcatccg  agacgtcct  cactcatga  ccatccctt  actagggtt  7500
aaaaccgac  caatccccg  ccgcctaaa  caagctaca  tcacatcaa  ccgaccagg  7560
ctattctat  gccaatgct  tgaaatttg  ggctcaaat  acagcttca  acccattgt  7620
ctagaaata  tgcctctaa  atatttcga  aactgatca  cttctataa  ttaaactca  7680
tgcgaagct  agagcgtta  ccttttaag  taaagttag  gacaacaaa  ctccacaat  7740
acatgccac  actagacac  tccacatga  ttattacaa  catctcctc  atagccaca  7800
tatttattt  atttcaatt  aaaatttct  cccaaacct  tcctgcacc  ccctcaccc  7860
aaactatag  cacagaaaa  acgaataac  cttgagaat  aaaatgaac  aaaatctat  7920
tgcctcttt  attaccccc  caataatag  tctaccaat  gttgtgacc  ttattatgt  7980
cccatcaat  ctattccca  catcagaac  cctaatcag  aaccgacta  actcatttc  8040
acactgact  atcaaactt  tcatcaaac  aataatgtt  attcacaca  caaaaggac  8100
aacctgagc  ctaataatt  tatccctaa  tatatttat  ggctcaacc  accttctag  8160
gcttcttcc  catacattt  cccctacca  tcagctatc  atagaccta  gcatagcca  8220
ccccctatg  gcaggagcc  taattctag  tttccgaca  aaactaaaa  attctttag  8280
ccacttctc  ccgcaagga  cccccatct  actaattcc  atactaatc  tcatcgaaa  8340
tatcagcct  tttattcaa  cgatagcac  agcagtacg  ctaacagca  acattacag  8400
aggccatct  ttaatgcat  taatcggag  agctaccct  gtacttata  acatcagcc  8460
accaaccgc  acaattaca  ttattattc  acttctact  acagtactt  aatttgccg  8520
agccttaat  caagcctat  tattcaccc  tctagtcag  ctgtaccta  atgataaca  8580
ataatgacc  accaaaccc  tgcatacca  atagtaaac  caagcccat  accactaac  8640
ggagcccta  cagctcttc  actcacatc  ggcttagta  tatgattcc  ttacaactc  8700
acaattctc  tatcattag  cctcctgac  aacatccta  ctatatatc  atgatgacg  8760
gatatcatc  gtgaaggaa  ataccaagg  caccacacc  ctattgtac  aaaaggcct  8820
cgatacgga  taatcctgt  tattgtctc  gaagtattc  tctttgccg  atttttctg  8880
gcattttat  attccagcc  agttcctac  cacgaccta  gcggttgct  acccccaac  8940
ggaatcacc  ctttaaatc  cctagaagt  ccccttcta  atacatcag  cctcttagc  9000
tcaggagtc  caattacat  agcccatca  agcctaata  aaggcaacc  aaaccatat  9060
aaccaagcc  tactaatca  cattctctt  ggattatat  tcactatct  acaagcctc  9120
gagtatttc  aaacatcat  ttctatctc  gacggaatt  acggctcaa  attcttcat  9180
gcaacggga  ttcatggcc  ccacgtaat  attggctca  ctttcctaa  tgtctgtct  9240
ctacgacaa  taaaattcc  cttcacatc  aaacatcat  tcggatttg  agccgcagc  9300
tgatactga  acttcgtag  tgtagtttg  ctattccta  acgtttcta  ctattgatg  9360
ggatcctac  cccttagta  aaacaatac  actgacttc  aatcagtta  ttctgaaaa  9420
actcagaag  gagtaatta  cctacccat  atcatcaca  ttaacatca  cttatcctt  9480
atcctcatt  caattgcat  ctgattgcc  caaataaac  tatactccg  aaaagcaaa  9540
ccatatgaa  gtggcttcg  cccaacaag  tctgcacgc  ttccttttt  aataaaatt  9600
ttcttagta  ccattacat  tctactatt  gacctagaa  tcgccttac  acttcccct  9660
ccatgagcg  ttcaaacaa  caataccac  acaataata  caactgcct  tattttagt  9720
actattttg  ctcttggcc  agcctacga  tgaacacaa  aaggactag  atgaacaga  9780
taattggta  ttagtttaa  taaaattaa  gatttcgac  cattagatt  tgataataa  9840
cataattac  aacaatgac  tctgctttc  taaatttaa  tatagcctt  acattatct  9900
tactaggta  ttttatatt  cgctcccac  taatatcca  tctcctctg  ctagaagga  9960
taatactat  actatttgt  ataacttca  catccacat  aaactccaa  tccataatc  10020
ccataacca  cccaattac  attctagtt  ttgcagcct  cgaagcagc  gtaggttta  10080
ccttactag  aaaaatttc  aatacttac  gaacagact  cgtacaaaa  ctcaacctt  10140
tacaatgtt  aaaattatt  tcccatcta  catactcct  ccactaaca  gactctcag  10200
caacaaaaa  atctgaacc  atgtcacct  ctacagctt  ctagtgagc  tattaagct  10260
atcactcct  tgacaaaat  acgaaaatt  cctaaattt  tcagttata  tctcctccg  10320
tccattatc  accccacta  tcattctaa  aacttgact  ctcccacta  taatgctcg  10380
tagccaaaa  cacataaaa  aagaaaata  aatgcatca  aaactttac  tctcaatac  10440
tattagcct  caaatttta  tcatcataa  attctccgc  acagaacta  ttttatttt  10500
tatcctgtt  gaggccact  taatcccaa  actaattat  attacacga  gaggcaacc  10560
aacagaacg  ttaaatgca  gaatttatt  cctgtttta  acactaatt  gctccatcc  10620
actcttaat  gccctcatt  caatccaaa  ctcaatagg  acactcaac  tcctaatcc  10680
ttccctcac  acacacccc  taccctcaa  atgatccaa  accattcta  gactagcat  10740
tataatagc  tttataatc  aaataccat  atacggagt  catctatga  taccaaaag  10800
ccacgtaga  gctccaatt  caggctcta  aattttagc  gcaattctc  taaagctag  10860
gggttatgg  ataatacga  tttccatca  tctagaccc  ctaacaaaa  ctttagcct  10920
cccattcat  atcctctca  tatgaggca  aattataac  agctcaatc  gcctacgcc  10980
aacagatct  aaatcatta  ttgcttact  atcagtaag  catatagcc  tagtcatca  11040
agccattat  atccagaca  catgaagct  catgggagc  acaatacta  taatcgccc  11100
cggcttaac  tcatcactc  tattctgcc  agcaaacac  aactacgaa  gaattcaca  11160
ccgaactat  attatagct  gaggattac  aataatctt  ccattgata  caacatgat  11220
actattagc  agcttagcc  acctagcac  accacccct  attaacctc  taggcgagt  11280
attcattgt  atagcaaca  tttcctgat  gaacccctc  atcatcctt  tagcaacta  11340
cattgtcat  acaggaata  actcaatat  tatgattat  acaacccaa  gaggaaaac  11400
aaccagcca  ataaacaac  tccaacctt  ccacacacg  gaattaaca  tcatagctc  11460
acacattat  cccctcata  tattaacaa  caaccctaa  ctcatcaca  gcctaacaa  11520
atgtagata  agtttacaa  aaacattag  ctgtgaatc  aacaacagg  aatcaaatt  11580
cttatttac  aagaaagta  gcaagaact  ctaattcat  cacccatac  taaaacata  11640
ggctttctt  cttttatag  atagaagta  tccattggt  ttaggaacc  aaaaccttg  11700
tgcaactcc  aataaaagt  ataaatata  taacaatcc  aatcctcat  attcttgat  11760
tacttacaa  accaatcac  ttttcaata  caatcttaa  caaacttat  tacttccgt  11820
atatgctca  tacatcaat  aaattctca  tcctcctta  cctcttacc  ttactacta  11880
tcttccacc  caacacaga  tacataatt  ctaactgac  ttgactaac  attaattct  11940
ttaaactta  tataagttt  aaaattgac  atttctcaa  cctattcct  tcagtatcc  12000
tattcgtaa  atgatcaat  atacaattc  cttcatgat  tatacactc  gacccccac  12060
ttaaccgat  cattaagta  ttaataata  tcctgaata  catactaat  ctaacctca  12120
ctaacaatc  attccaact  tttattgga  gagaagggg  aggaattat  tccttctta  12180
taatcggat  atgatatgg  cttgcagac  ccaacacag  ggccctcca  gcaatcctc  12240
acaaccgag  cggagacat  ggtttcatc  tagctataa  ctgattctg  ctaaacata  12300
actcctgag  actccaaca  attttctta  ccaacacca  caacaatct  gtccctctc  12360
caggactac  aattgcagc  acaggaaaa  ccgcccaat  cggacttca  ccatgactc  12420
catcagcta  agaaggccc  actcccgtc  ctgccctac  acactcaag  acaatagtt  12480
tagcaggga  cttcctaat  atccgattc  accccctaa  ctcaaacaa  agtactatt  12540
taacagcca  actatgtct  ggtgcaatc  ccacattat  cacagcaat  tgtgctctc  12600
cccaaaacg  catcaaaaa  atcgtagct  tctcaacat  cagccaact  ggccttata  12660
tagtcacat  agggattaa  caaccctac  ttgctttcc  ccacatttg  acccatgca  12720
tcttcaaag  catattatt  atatgctcc  gatcaatca  ccatatcct  aacgatgaa  12780
aagacattc  aaaaatagg  aatataata  aagcaatac  attcacatc  tcttgtctc  12840
ttatcggaa  cctagccct  accggaata  ctttcctca  aggattcta  tcaaaagat  12900
tcatcatcg  agccatcaa  acgtgtaac  ccaacgcct  agccctaat  atcacttta  12960
tcgccacat  cataactgc  gtgtacagc  tacggatca  ctacttcgt  accatgaca  13020
aaccacgat  ctccccact  attactatt  atgaaaaca  cccaaacct  attaatcca  13080
tcaaacgcc  agcattagg  agcatccta  caggcttcc  tatctcact  aatattcct  13140
caactaaca  tcaaattct  acaataccc  gacatttaa  aataacagc  ctacttatt  13200
caatcctag  atttgccat  gccctagaa  ttaacaatt  aacactaaa  ctatcaata  13260
gcaaaccca  caaactatc  tcattctca  cctccctag  ctactaccc  ccaattata  13320
cccgaatta  tcctcaaaa  actctaaat  ctagctaca  attatcctt  aacctacta  13380
acctaatct  atcagaaaa  acaatccca  aatcaacct  aatcaccca  acccaacta  13440
ctaaaataa  atccaacca  aaaggacta  tcaaactat  tttcctatc  tttctcatc  13500
ctatttcac  aatttttat  ttacacaca  ttaatcccg  gtgatttca  taataataa  13560
aatccccgc  aacaatgac  acccagcca  cactatcat  caagtagca  aactataaa  13620
agccgcaac  ccaatcccc  cctccaaca  aaccccaac  tcatcaatc  catacatta  13680
tcaatcgcc  agactatca  aatcaacta  ctccacctt  ttattcaaa  taaacaagt  13740
gaacactac  aactccata  aaagcccta  aacaaaaaa  ctaaaaata  accaattag  13800
ccctcaagt  tccggatat  cctcagtag  catagcagt  gtataccca  atacaacca  13860
catcccacc  aaataaatt  aaaatacta  taaacctaa  aacgaaccc  caaacccta  13920
aactattaa  cacccaata  atccactaa  aatcaatcc  aacccacca  aaataggtg  13980
aggcttcaa  gccaaccct  gacaaccag  caaaaacag  aaacttaaa  taaacatat  14040
atttgtcat  atttctaca  agcatttaa  tgtgactaa  gacatgaaa  atcatcgtt  14100
taattcaac  atagaaaca  ctaatgaca  acatccgaa  atctcaccc  ctattcaaa  14160
tcatcaacc  ctcctttat  gacctaccg  ccccatcta  catctcatc  tgatgaaac  14220
tcggttctc  actaggagt  tgcctcata  tacaaatcc  cacaggctt  ttcctagca  14280
tacactaca  gtctgatac  ataacagca  tctcatcag  cacccacat  tgccgagac  14340
taaactacg  ctgactaat  cgataccta  aagccaacg  cgcctcaat  tttttcatc  14400
gcctattcc  ccatgtggg  cgaggacta  actatggat  ctacacttt  ctagaaacc  14460
gaaacattg  gatcatcct  ctatttgca  tcatagcaa  tgcattcat  ggctatgta  14520
tcccatgag  acaaatatc  ttctgagga  ctacagtaa  tacaaacct  ttatcagct  14580
tcccttaca  tgggactac  ctagtcgaa  gaatctgag  aggcttctc  gtagacaaa  14640
caaccctaa  acgcttctt  gcattccac  tcatcctcc  attcattat  gccgccctt  14700
caattgtac  tcttctttt  ctccacgaa  caggatcaa  taaccccac  ggattaaac  14760
ccgacgcag  caaaatccc  ttccatcca  attatacaa  taaagacct  ctaggtgta  14820
ttatattac  attattcct  ataacccta  tactattct  cccagacct  ctaggagac  14880
cagacaatt  tacacccgc  aaccccctc  acaccccac  ccacatcaa  ccagaatga  14940
actttctct  tgcctacgc  attctacgc  ccattccca  caaactagg  ggggtcgta  15000
ccctaatct  atcaatcct  atcttagcc  tcctaccat  cctgcatac  tcaaaacaa  15060
gcagcttaa  attccgccc  atcacccaa  tcctttact  aatcctagt  gccaacctc  15120
tagtcttaa  atgaatcgg  ggccaacca  tagaacacc  atttatcat  attggtcaa  15180
tagcctcca  cagttattt  tcaattatc  tcattctca  accaatctc  ggaattgtt  15240
aagacaaaa  gttaaaatg  aattaatgt  ccgatagta  aaaaattac  ctggtcttg  15300
aaaccaaaa  tgaagagtc  gtcttctca  gacaatcaa  aagaaggaa  tacctcccc  15360
ccatcaaca  ccaaagctg  tattctact  aaactactt  ttgtcagta  ataaaatga  15420
atggacatt  aaacattta  gtatatcgt  cattaaatt  ttttcccca  gcatataag  15480
atgtaatat  tatctaatg  tttaggaca  acatttaaa  tcaactata  attcacaac  15540
acatgtcta  tctcaaata  attaagata  tgcttatta  acatatctg  gttattaga  15600
atgcaccat  aagtcataa  cctttctct  ccatatgac  atccctgtc  ccaattggt  15660
tctatttct  ccatcctcc  tgaaatcaa  aacccgccc  ctcgtcccc  tcttctcgc  15720
ccgggccca  tcgtcctgg  ggtgactat  ctgaaactt  accaggcat  tggttctta  15780
ttcagggcc  tcaattggt  catcgtcca  acgttcccc  taaataaga  atctcgatg  15840
taacgggtc  aatcagccc  tgatcaaca  aactgtggt  atatacatt  ggtattttt  15900
aattttcgg  tgccttcct  aacatagcc  tcaaggcat  aaggtcagc  caaagtcct  15960
tggaacctt  tagttaagg  tcatttatc  tcatagaca  agctcgaaa  actatttta  16020
tcatgtttg  aagacataa  tatttataa  tactgaaaa  tctgtcaac  aaccccccc  16080
ccccctaca  ctgaaactt  aatgccaaa  cccaaaaac  ttaaagcaa  aattaaata  16140
aacaaaaag  tacttaatt  ttaaaaggc  tctccattc  agtagacca  aaaatttta  16200
cttaaatct  agcattggt  aaatttccc  acacaaaat  tttcctcct  actaaaccc  16260
ctttacttg  ctaccctca  aaaattcca  atacaccaaa  16300



<210> 9423
<211> 16300
<212> DNA
<213> Rattus norvegicus
<308> X14848
<400> 9423

gttaatgta  cttataata  agcaaagca  tgaaaatgc  tagatggat  caaaaatcc  60
ataaacaca  aggtttggt  ctggcctta  aattaattg  aggtaagat  acacatgca  120
acatccata  accggtgta  aatccctta  agatttgcc  aaaacttaa  gagagggca  180
caagcacat  atatagctc  agacgcctt  cctagccac  cccccacgg  actcagcag  240
gataaatat  aagcaatga  cgaaagttt  actaagcta  tacctctca  ggttggtaa  300
tttcgtgcc  gccaccgcg  tcatacgat  aacccaaac  aattatttt  ggcgtaaaa  360
gtgccaact  taaatctca  aatagaatt  aaatccaac  tatatgtga  aattcattg  420
taggaccta  gcccaataa  gaaagtaat  ctaatcatt  atataatgc  cgatagcta  480
gacccaaac  gggattaga  accccacta  gcttagccc  aaaccttaa  aattaaacc  540
acaaaatta  ttgccagag  actactagc  acagcttaa  actcaaagg  cttggcggt  600
ctttatatc  atctagagg  gcctgttct  taatcgata  accccgttc  accttaccc  660
ttctcgcta  ttcagccta  ataccgcca  cttcagcaa  ccctaaaaa  gcactaaag  720
aagcacaag  acaaacata  aaacgttag  tcaaggtgt  gccaatgaa  cggaaagaa  780
tgggctaca  tttcttttc  cagagaaca  tacgaaacc  ttatgaaac  aaaggacaa  840
ggaggattt  gtagtaaat  aagaataga  agcttaatt  aatagagca  tgaagtacg  900
acacaccgc  cgtcaccct  ctcaaatta  attgacatt  acatataca  aatttcact  960
acaaattta  gagaggaga  aagtcgtaa  aaggtaagc  tactggaaa  tgtgcttgg  1020
ataatcaca  tgtagctta  tcacaaagc  tctggccta  acccagaag  attcataaa  1080
aatgaacac  ttgaactaa  cctagccct  caaccaacc  acataacta  acccccaca  1140
aaactaaaa  atttaactc  aaaagtatt  gagaaagaa  tttacttac  aagagctat  1200
gagaaagta  cgcaaggga  atgatgaaa  actaattta  agtaaaaac  agacaaaga  1260
taaacctgt  ccttttgca  aatgaatta  ctagaaaat  cttaacaaa  agaatttaa  1320
ctaagaacc  cgaaaccaa  cgagctacc  aaaaacaat  tcatgaatc  acccgtcta  1380
gtagcaaaa  agtgggaag  tttttaggt  gaggtgaaa  gcctatcga  cttggtgat  1440
gctggttgc  caaaaaaga  tttcagttc  aactttaag  ttccatcag  acaacaaat  1500
aaaatgtaa  cttaaaata  agccaaaag  gggacagct  tttaggaaa  ggaaaaaac  1560
ttaaatagt  aataaacaa  tacaatcac  taaccattg  aggcttaaa  gcaagccat  1620
aataaagaa  gcgtcaagc  acatcatct  acacacaca  taattccac  aacctcaaa  1680
attccaaaa  tacaaattg  gctaaatct  tgatcctag  gaatactgt  aatatgtga  1740
caagaacca  tccaccaag  acaagtgct  agacaaccg  ataaccatt  ttaattatt  1800
aatcatagg  ataacccaa  aatagaatt  cctatccct  actcgttag  ccaacacag  1860
cgtgcttta  ggaaagttt  aaaaagtaa  ggaactcgg  aaacacgaa  cccgcctgt  1920
taccaaaaa  atctcctct  gcataacaa  tattagtgg  atcgcctgc  cagtgacta  1980
agttccacg  ccgcggtat  ccgaccgtg  aaaggtagg  taatcactt  ttccttaat  2040
agggactag  atgaatggc  aaacgaggg  ccaaccgtc  cttacttgc  atcagtgaa  2100
ttgaccttc  agtgaaggg  cggactcat  ataaaagac  agaagaccc  atggagctt  2160
aatttacta  tttcaattt  tataaaaaa  cctaatggg  gaaaacaac  aaattatga  2220
ctaccaaat  tcggttggg  tgacctcgg  gaataaaaa  tcctccgaa  gattataac  2280
gagtcggta  ccgtgtccg  cccagtcaa  taatactaa  atcttattg  cccaattat  2340
gatcaacgg  ccaagttac  ctagggtaa  agcgcgacc  atttaagag  tcatatcga  2400
aattagggt  tacgacctc  atgttggat  aggacatcc  aatggtgca  aagctatta  2460
tggttcgtt  gttcaacga  taaagtcct  cgtgatcta  gtccggcaa  ccaggtcgg  2520
ttctatcta  ttacaattt  tcccagtta  gaaaggaca  gagaaatgg  gaccaacca  2580
tcctaggct  ccaaccaat  tagaaaaac  taataaagt  tatatgtac  ataaataac  2640
ttagaccca  gttattagg  tggcagagc  aagtaattg  gtaagactt  aaaccttgt  2700
cccagaggt  caaatcctc  ccctaatag  gtactttat  aatatccta  cactcctaa  2760
cccaatctt  attgccata  gccttctca  cctagtaga  cggaaaatc  taggctaca  2820
acaattacg  aaaggcccc  acaacgaag  cccatatgg  aaactacaa  catttgcag  2880
tgccataaa  ctattcata  aagaaccca  acgccctct  accacctca  tatcactat  2940
tattatcgc  ccaaccctc  cccttacac  agctctaag  ctatgaatt  ccttaccaa  3000
accccaccc  cttatcaac  tcaacctag  cataccatt  attctagcc  catccagcc  3060
ttcggtcta  tccattcta  gatcgggat  agcctcaaa  tcaaaatac  ccctattcg  3120
agccctacg  gccgttgcc  aaaccatct  ttacgaagt  acaatagcc  tatacctct  3180
atccgtcct  ctaataagc  gctccttct  cctacaaat  cttatcact  cacaagaac  3240
tatctgact  ttaatcccc  cctgaccaa  agccataat  tgatacatt  caaccctcg  3300
agaaacaaa  cgagctccc  tcgacttaa  agaaggaga  tcagaatta  tctcaggct  3360
taacgtcga  tacgccgca  gaccattcg  cctattctt  atagccgag  acaccaaca  3420
tattctaat  aacgcccta  catcaattg  attcctagg  cccttatat  atatcaatt  3480
ccctgaatt  tactcaacc  gcttcataa  agaaacact  cttctatcc  caactttcc  3540
atggattcg  gcatcctac  cccgttttc  atatgacca  ctaatgcac  tcctatgaa  3600
aaatttcct  ccactaaca  tagcattct  catatgata  atttccctg  caattttcc  3660
agcaggaat  ccaccctac  catagaaat  tgtctgaca  aagagttac  ttgatagag  3720
aaataatag  ggtttaaat  ctcttattt  taggacaat  ggaattgaa  ctacaccta  3780
gaattcaaa  ttctccgtg  caccaatac  ccctatcct  catagtaag  tcagctaac  3840
aagctatcg  gcccatacc  cgaaaatgt  ggttaaacc  ttcccgtac  aataaatcc  3900
attacccta  ccattattt  cttaaccac  tttaaaggc  gcctaatca  gacacttag  3960
accaactta  caccaatat  agtaggatt  gaaataagc  ttttagcta  catcccact  4020
ctagccaac  aaaaaagcc  acgatcaac  gaagcagca  caaaatatt  tctaaccca  4080
gctacagcc  caataatta  cctactagt  atcatcctc  actacaaac  atcaggaat  4140
tgaaccctt  aacaacaaa  caataacat  ctactcaac  taatactca  ttcactggc  4200
ataaaactt  gactagccc  attccacta  tgactaccc  aagtcaccc  aggaattcc  4260
ctacacatt  gattaatct  actaacatg  caaaaaatt  ctccactat  aattctata  4320
caattttat  aactcctaa  cccaactat  accaccatt  tcgcaattt  atcagtctt  4380
gttggcgcc  gaggaggac  taaccagac  caaacacga  aaatcatag  atactcatc  4440
attgcccac  taggatgaa  aacagcaat  cttccatac  accctaact  aaccctcct  4500
aacttaaca  tttacatcc  acttactgt  ccaatattc  attacatca  aacaaactc  4560
gcaacaaca  tcaacacac  ctcactcgc  tgaaataaa  ctcccataa  cctaaccat  4620
gcatccatc  tcctcctat  actaggagg  ctcccccct  tcacaggat  tttaccaaa  4680
tgagcaatt  tctccgagc  tctaaaaaa  aactgctca  ccctatcaa  actaatagc  4740
atcatagcc  tattaagcc  attcttcta  actcgacta  tttactcta  atccctcac  4800
acattccca  ccaacaaca  ctccaaaat  atctcccac  accaaaacc  aaaacataa  4860
tttatcctc  caaccctca  agtattaag  accctaacc  taccgcttt  ctcccaact  4920
atcacatag  agtttagga  atacagttc  agagccttc  aagccctta  aaaacaaac  4980
agtttaact  ctgataagg  ctgtaagac  atatcttac  tctgttaaa  gcaaatcaa  5040
tgctttaat  aagctaaat  ctcaactag  ttggaagga  tcaaattcc  acgaaaatt  5100
agttaacag  taaataccc  acttactgg  ttcaatcta  ttctcccgc  tatcagaaa  5160
gaggcggga  aagccttag  agaggagat  ctctacacc  tcgaacttg  aattcgaca  5220
gataatcac  ttaaggctt  ttggtaaaa  gggggctca  cccctgtct  tagatttac  5280
gtctaatgc  tactcagcc  ttttaccta  gttcgtaaa  cgttgactc  tttcaacta  5340
ccacaaaga  atcggaacc  tctacctat  atttggagc  tgagcagga  tagtaggga  5400
agctttgag  attctaatt  gagctgaac  aggacagcc  ggcgcactc  taggagatg  5460
ccaaatcta  aatgtcatc  tcacagccc  tgcattcgt  ataattttc  ttatagtaa  5520
acctataat  attggaggc  tcggaaact  acttgtacc  ctaataatt  gagcccctg  5580
tatagcatt  ccacgaata  ataacataa  cttttgact  cttcctcca  catttctac  5640
ccttttagc  tcctccata  tagaagctg  agctggaac  ggatgaaca  tatatcccc  5700
cttagccgg  aacctagcc  atgctgggg  atccgtaga  ttaactatt  tttccctcc  5760
cctagccgg  gtgtcttct  tcttaggag  tatcaactt  atcaccact  tcattaata  5820
aaaaccccc  gctataacc  aatatcaga  acctctctt  gtatgatcc  tactaatta  5880
agccgtcct  ctacttctc  cactgccag  attagcagc  ggtatcact  tactcctta  5940
agaccgaaa  ctaaatact  ctttcttcg  ccccgctgg  ggtggagac  caattcttt  6000
tcaacacct  ttctgattc  tcggccacc  agaagtgta  atcttaatt  ttccagggt  6060
tggaattat  tcacatgta  ttacctatt  ctctggaaa  aaagaaccc  tcggatata  6120
aggtatggt  tgaaccata  tatctattg  cttcctagg  tttattgta  gagcacatc  6180
catattcac  gtaggccta  atgtagaca  ccgagccta  tttacatct  ccactataa  6240
tatcgcaat  cctacaggc  taaaagtat  cagctgact  gctacacta  atggaggaa  6300
tatcaaatg  tcccccgcc  tattatgag  cttagggtt  atcttctta  tcacagtag  6360
gggcctaac  gggatcgta  tatctaact  atcccttga  attgtactt  atgatacat  6420
ctacgtagt  gctcacttc  actatgtct  atctatagg  gcagtattc  ccatcatag  6480
tggcttcgt  cactgattc  cactattct  aggctatac  ctaaatgac  catgagcaa  6540
agcccactt  gccattata  ttgtaggtg  aaacataac  ttttttcct  aacacttcc  6600
aggattagc  gggatacct  gtcgttact  tgattatcc  gatgcttat  ccacatgaa  6660
tacagtctc  tctataggc  cattcatct  acttacggc  gtccttgta  tgatcttca  6720
gatttgaga  gccttcgca  caaaacgag  agtgctctc  atttcctac  cttcaacta  6780
cctagaatg  ctgcatgga  gccccccac  ttaccacac  ttcgaagaa  cttcctatg  6840
aaaagttaa  taagaaagg  aggaatcga  cccctacaa  tggtttcaa  ccaatttca  6900
aaccattat  tctttctca  tgagatatt  gtaaaataa  tacataacc  tgtcaaggt  6960
aagttatag  cctaatcct  tatatctta  atggcttac  catttcaac  tggcttaca  7020
gacgctaca  cacctatca  agaagaact  acaaacttt  atgaccaca  cctaataat  7080
gtattcctc  tcagctccc  agtacttta  attatttca  taatactaa  aacaaaact  7140
acacacaca  gcacaatag  cgcccaaga  gtagaaaca  tttgaacaa  tctcccagc  7200
gtcattctt  ttctaattg  ccttccctc  ctacgaatt  tatacataa  agacgagat  7260
aataaccca  ttctaacag  aaaaactat  ggacaccaa  gatactgaa  ctatgaata  7320
actgactat  aagacctat  ctttgactc  tacataatc  caaccaatg  cctaaaacc  7380
ggtgaactt  gtctattag  agttgataa  cgggtagtc  taccaatag  acttccaat  7440
cgtatacta  tctcatccg  agacgtcct  cactcatga  ccatccctt  actagggtt  7500
aaaaccgac  caatccccg  ccgcctaaa  caagctaca  tcacatcaa  ccgaccagg  7560
ctattctat  gccaatgct  tgaaatttg  ggctcaaat  acagcttca  acccattgt  7620
ctagaaata  tgcctctaa  atatttcga  aactgatca  cttctataa  ttaaactca  7680
tgcgaagct  agagcgtta  ccttttaag  taaagttag  gacaacaaa  ctccacaat  7740
acatgccac  actagacac  tccacatga  ttattacaa  catctcctc  atagccaca  7800
tatttattt  atttcaatt  aaaatttct  cccaaacct  tcctgcacc  ccctcaccc  7860
aaactatag  cacagaaaa  acgaataac  cttgagaat  aaaatgaac  aaaatctat  7920
tgcctcttt  attaccccc  caataatag  tctaccaat  gttgtgacc  ttattatgt  7980
cccatcaat  ctattccca  catcagaac  cctaatcag  aaccgacta  actcatttc  8040
acactgact  atcaaactt  tcatcaaac  aataatgtt  attcacaca  caaaaggac  8100
aacctgagc  ctaataatt  tatccctaa  tatatttat  ggctcaacc  accttctag  8160
gcttcttcc  catacattt  cccctacca  tcagctatc  atagaccta  gcatagcca  8220
ccccctatg  gcaggagcc  taattctag  tttccgaca  aaactaaaa  attctttag  8280
ccacttctc  ccgcaagga  cccccatct  actaattcc  atactaatc  tcatcgaaa  8340
tatcagcct  tttattcaa  cgatagcac  agcagtacg  ctaacagca  acattacag  8400
aggccatct  ttaatgcat  taatcggag  agctaccct  gtacttata  acatcagcc  8460
accaaccgc  acaattaca  ttattattc  acttctact  acagtactt  aatttgccg  8520
agccttaat  caagcctat  tattcaccc  tctagtcag  ctgtaccta  atgataaca  8580
ataatgacc  accaaaccc  tgcatacca  atagtaaac  caagcccat  accactaac  8640
ggagcccta  cagctcttc  actcacatc  ggcttagta  tatgattcc  ttacaactc  8700
acaattctc  tatcattag  cctcctgac  aacatccta  ctatatatc  atgatgacg  8760
gatatcatc  gtgaaggaa  ataccaagg  caccacacc  ctattgtac  aaaaggcct  8820
cgatacgga  taatcctgt  tattgtctc  gaagtattc  tctttgccg  atttttctg  8880
gcattttat  attccagcc  agttcctac  cacgaccta  gcggttgct  acccccaac  8940
ggaatcacc  ctttaaatc  cctagaagt  ccccttcta  atacatcag  cctcttagc  9000
tcaggagtc  caattacat  agcccatca  agcctaata  aaggcaacc  aaaccatat  9060
aaccaagcc  tactaatca  cattctctt  ggattatat  tcactatct  acaagcctc  9120
gagtatttc  aaacatcat  ttctatctc  gacggaatt  acggctcaa  attcttcat  9180
gcaacggga  ttcatggcc  ccacgtaat  attggctca  ctttcctaa  tgtctgtct  9240
ctacgacaa  taaaattcc  cttcacatc  aaacatcat  tcggatttg  agccgcagc  9300
tgatactga  acttcgtag  tgtagtttg  ctattccta  acgtttcta  ctattgatg  9360
ggatcctac  cccttagta  aaacaatac  actgacttc  aatcagtta  ttctgaaaa  9420
actcagaag  gagtaatta  cctacccat  atcatcaca  ttaacatca  cttatcctt  9480
atcctcatt  caattgcat  ctgattgcc  caaataaac  tatactccg  aaaagcaaa  9540
ccatatgaa  gtggcttcg  cccaacaag  tctgcacgc  ttccttttt  aataaaatt  9600
ttcttagta  ccattacat  tctactatt  gacctagaa  tcgccttac  acttcccct  9660
ccatgagcg  ttcaaacaa  caataccac  acaataata  caactgcct  tattttagt  9720
actattttg  ctcttggcc  agcctacga  tgaacacaa  aaggactag  atgaacaga  9780
taattggta  ttagtttaa  taaaattaa  gatttcgac  cattagatt  tgataataa  9840
cataattac  aacaatgac  tctgctttc  taaatttaa  tatagcctt  acattatct  9900
tactaggta  ttttatatt  cgctcccac  taatatcca  tctcctctg  ctagaagga  9960
taatactat  actatttgt  ataacttca  catccacat  aaactccaa  tccataatc  10020
ccataacca  cccaattac  attctagtt  ttgcagcct  cgaagcagc  gtaggttta  10080
ccttactag  aaaaatttc  aatacttac  gaacagact  cgtacaaaa  ctcaacctt  10140
tacaatgtt  aaaattatt  tcccatcta  catactcct  ccactaaca  gactctcag  10200
caacaaaaa  atctgaacc  atgtcacct  ctacagctt  ctagtgagc  tattaagct  10260
atcactcct  tgacaaaat  acgaaaatt  cctaaattt  tcagttata  tctcctccg  10320
tccattatc  accccacta  tcattctaa  aacttgact  ctcccacta  taatgctcg  10380
tagccaaaa  cacataaaa  aagaaaata  aatgcatca  aaactttac  tctcaatac  10440
tattagcct  caaatttta  tcatcataa  attctccgc  acagaacta  ttttatttt  10500
tatcctgtt  gaggccact  taatcccaa  actaattat  attacacga  gaggcaacc  10560
aacagaacg  ttaaatgca  gaatttatt  cctgtttta  acactaatt  gctccatcc  10620
actcttaat  gccctcatt  caatccaaa  ctcaatagg  acactcaac  tcctaatcc  10680
ttccctcac  acacacccc  taccctcaa  atgatccaa  accattcta  gactagcat  10740
tataatagc  tttataatc  aaataccat  atacggagt  catctatga  taccaaaag  10800
ccacgtaga  gctccaatt  caggctcta  aattttagc  gcaattctc  taaagctag  10860
gggttatgg  ataatacga  tttccatca  tctagaccc  ctaacaaaa  ctttagcct  10920
cccattcat  atcctctca  tatgaggca  aattataac  agctcaatc  gcctacgcc  10980
aacagatct  aaatcatta  ttgcttact  atcagtaag  catatagcc  tagtcatca  11040
agccattat  atccagaca  catgaagct  catgggagc  acaatacta  taatcgccc  11100
cggcttaac  tcatcactc  tattctgcc  agcaaacac  aactacgaa  gaattcaca  11160
ccgaactat  attatagct  gaggattac  aataatctt  ccattgata  caacatgat  11220
actattagc  agcttagcc  acctagcac  accacccct  attaacctc  taggcgagt  11280
attcattgt  atagcaaca  tttcctgat  gaacccctc  atcatcctt  tagcaacta  11340
cattgtcat  acaggaata  actcaatat  tatgattat  acaacccaa  gaggaaaac  11400
aaccagcca  ataaacaac  tccaacctt  ccacacacg  gaattaaca  tcatagctc  11460
acacattat  cccctcata  tattaacaa  caaccctaa  ctcatcaca  gcctaacaa  11520
atgtagata  agtttacaa  aaacattag  ctgtgaatc  aacaacagg  aatcaaatt  11580
cttatttac  aagaaagta  gcaagaact  ctaattcat  cacccatac  taaaacata  11640
ggctttctt  cttttatag  atagaagta  tccattggt  ttaggaacc  aaaaccttg  11700
tgcaactcc  aataaaagt  ataaatata  taacaatcc  aatcctcat  attcttgat  11760
tacttacaa  accaatcac  ttttcaata  caatcttaa  caaacttat  tacttccgt  11820
atatgctca  tacatcaat  aaattctca  tcctcctta  cctcttacc  ttactacta  11880
tcttccacc  caacacaga  tacataatt  ctaactgac  ttgactaac  attaattct  11940
ttaaactta  tataagttt  aaaattgac  atttctcaa  cctattcct  tcagtatcc  12000
tattcgtaa  atgatcaat  atacaattc  cttcatgat  tatacactc  gacccccac  12060
ttaaccgat  cattaagta  ttaataata  tcctgaata  catactaat  ctaacctca  12120
ctaacaatc  attccaact  tttattgga  gagaagggg  aggaattat  tccttctta  12180
taatcggat  atgatatgg  cttgcagac  ccaacacag  ggccctcca  gcaatcctc  12240
acaaccgag  cggagacat  ggtttcatc  tagctataa  ctgattctg  ctaaacata  12300
actcctgag  actccaaca  attttctta  ccaacacca  caacaatct  gtccctctc  12360
caggactac  aattgcagc  acaggaaaa  ccgcccaat  cggacttca  ccatgactc  12420
catcagcta  agaaggccc  actcccgtc  ctgccctac  acactcaag  acaatagtt  12480
tagcaggga  cttcctaat  atccgattc  accccctaa  ctcaaacaa  agtactatt  12540
taacagcca  actatgtct  ggtgcaatc  ccacattat  cacagcaat  tgtgctctc  12600
cccaaaacg  catcaaaaa  atcgtagct  tctcaacat  cagccaact  ggccttata  12660
tagtcacat  agggattaa  caaccctac  ttgctttcc  ccacatttg  acccatgca  12720
tcttcaaag  catattatt  atatgctcc  gatcaatca  ccatatcct  aacgatgaa  12780
aagacattc  aaaaatagg  aatataata  aagcaatac  attcacatc  tcttgtctc  12840
ttatcggaa  cctagccct  accggaata  ctttcctca  aggattcta  tcaaaagat  12900
tcatcatcg  agccatcaa  acgtgtaac  ccaacgcct  agccctaat  atcacttta  12960
tcgccacat  cataactgc  gtgtacagc  tacggatca  ctacttcgt  accatgaca  13020
aaccacgat  ctccccact  attactatt  atgaaaaca  cccaaacct  attaatcca  13080
tcaaacgcc  agcattagg  agcatccta  caggcttcc  tatctcact  aatattcct  13140
caactaaca  tcaaattct  acaataccc  gacatttaa  aataacagc  ctacttatt  13200
caatcctag  atttgccat  gccctagaa  ttaacaatt  aacactaaa  ctatcaata  13260
gcaaaccca  caaactatc  tcattctca  cctccctag  ctactaccc  ccaattata  13320
cccgaatta  tcctcaaaa  actctaaat  ctagctaca  attatcctt  aacctacta  13380
acctaatct  atcagaaaa  acaatccca  aatcaacct  aatcaccca  acccaacta  13440
ctaaaataa  atccaacca  aaaggacta  tcaaactat  tttcctatc  tttctcatc  13500
ctatttcac  aatttttat  ttacacaca  ttaatcccg  gtgatttca  taataataa  13560
aatccccgc  aacaatgac  acccagcca  cactatcat  caagtagca  aactataaa  13620
agccgcaac  ccaatcccc  cctccaaca  aaccccaac  tcatcaatc  catacatta  13680
tcaatcgcc  agactatca  aatcaacta  ctccacctt  ttattcaaa  taaacaagt  13740
gaacactac  aactccata  aaagcccta  aacaaaaaa  ctaaaaata  accaattag  13800
ccctcaagt  tccggatat  cctcagtag  catagcagt  gtataccca  atacaacca  13860
catcccacc  aaataaatt  aaaatacta  taaacctaa  aacgaaccc  caaacccta  13920
aactattaa  cacccaata  atccactaa  aatcaatcc  aacccacca  aaataggtg  13980
aggcttcaa  gccaaccct  gacaaccag  caaaaacag  aaacttaaa  taaacatat  14040
atttgtcat  atttctaca  agcatttaa  tgtgactaa  gacatgaaa  atcatcgtt  14100
taattcaac  atagaaaca  ctaatgaca  acatccgaa  atctcaccc  ctattcaaa  14160
tcatcaacc  ctcctttat  gacctaccg  ccccatcta  catctcatc  tgatgaaac  14220
tcggttctc  actaggagt  tgcctcata  tacaaatcc  cacaggctt  ttcctagca  14280
tacactaca  gtctgatac  ataacagca  tctcatcag  cacccacat  tgccgagac  14340
taaactacg  ctgactaat  cgataccta  aagccaacg  cgcctcaat  tttttcatc  14400
gcctattcc  ccatgtggg  cgaggacta  actatggat  ctacacttt  ctagaaacc  14460
gaaacattg  gatcatcct  ctatttgca  tcatagcaa  tgcattcat  ggctatgta  14520
tcccatgag  acaaatatc  ttctgagga  ctacagtaa  tacaaacct  ttatcagct  14580
tcccttaca  tgggactac  ctagtcgaa  gaatctgag  aggcttctc  gtagacaaa  14640
caaccctaa  acgcttctt  gcattccac  tcatcctcc  attcattat  gccgccctt  14700
caattgtac  tcttctttt  ctccacgaa  caggatcaa  taaccccac  ggattaaac  14760
ccgacgcag  caaaatccc  ttccatcca  attatacaa  taaagacct  ctaggtgta  14820
ttatattac  attattcct  ataacccta  tactattct  cccagacct  ctaggagac  14880
cagacaatt  tacacccgc  aaccccctc  acaccccac  ccacatcaa  ccagaatga  14940
actttctct  tgcctacgc  attctacgc  ccattccca  caaactagg  ggggtcgta  15000
ccctaatct  atcaatcct  atcttagcc  tcctaccat  cctgcatac  tcaaaacaa  15060
gcagcttaa  attccgccc  atcacccaa  tcctttact  aatcctagt  gccaacctc  15120
tagtcttaa  atgaatcgg  ggccaacca  tagaacacc  atttatcat  attggtcaa  15180
tagcctcca  cagttattt  tcaattatc  tcattctca  accaatctc  ggaattgtt  15240
aagacaaaa  gttaaaatg  aattaatgt  ccgatagta  aaaaattac  ctggtcttg  15300
aaaccaaaa  tgaagagtc  gtcttctca  gacaatcaa  aagaaggaa  tacctcccc  15360
ccatcaaca  ccaaagctg  tattctact  aaactactt  ttgtcagta  ataaaatga  15420
atggacatt  aaacattta  gtatatcgt  cattaaatt  ttttcccca  gcatataag  15480
atgtaatat  tatctaatg  tttaggaca  acatttaaa  tcaactata  attcacaac  15540
acatgtcta  tctcaaata  attaagata  tgcttatta  acatatctg  gttattaga  15600
atgcaccat  aagtcataa  cctttctct  ccatatgac  atccctgtc  ccaattggt  15660
tctatttct  ccatcctcc  tgaaatcaa  aacccgccc  ctcgtcccc  tcttctcgc  15720
ccgggccca  tcgtcctgg  ggtgactat  ctgaaactt  accaggcat  tggttctta  15780
ttcagggcc  tcaattggt  catcgtcca  acgttcccc  taaataaga  atctcgatg  15840
taacgggtc  aatcagccc  tgatcaaca  aactgtggt  atatacatt  ggtattttt  15900
aattttcgg  tgccttcct  aacatagcc  tcaaggcat  aaggtcagc  caaagtcct  15960
tggaacctt  tagttaagg  tcatttatc  tcatagaca  agctcgaaa  actatttta  16020
tcatgtttg  aagacataa  tatttataa  tactgaaaa  tctgtcaac  aaccccccc  16080
ccccctaca  ctgaaactt  aatgccaaa  cccaaaaac  ttaaagcaa  aattaaata  16140
aacaaaaag  tacttaatt  ttaaaaggc  tctccattc  agtagacca  aaaatttta  16200
cttaaatct  agcattggt  aaatttccc  acacaaaat  tttcctcct  actaaaccc  16260
ctttacttg  ctaccctca  aaaattcca  atacaccaaa  16300



<210> 9424
<211> 16300
<212> DNA
<213> Rattus norvegicus
<308> X14848
<400> 9424

gttaatgta  cttataata  agcaaagca  tgaaaatgc  tagatggat  caaaaatcc  60
ataaacaca  aggtttggt  ctggcctta  aattaattg  aggtaagat  acacatgca  120
acatccata  accggtgta  aatccctta  agatttgcc  aaaacttaa  gagagggca  180
caagcacat  atatagctc  agacgcctt  cctagccac  cccccacgg  actcagcag  240
gataaatat  aagcaatga  cgaaagttt  actaagcta  tacctctca  ggttggtaa  300
tttcgtgcc  gccaccgcg  tcatacgat  aacccaaac  aattatttt  ggcgtaaaa  360
gtgccaact  taaatctca  aatagaatt  aaatccaac  tatatgtga  aattcattg  420
taggaccta  gcccaataa  gaaagtaat  ctaatcatt  atataatgc  cgatagcta  480
gacccaaac  gggattaga  accccacta  gcttagccc  aaaccttaa  aattaaacc  540
acaaaatta  ttgccagag  actactagc  acagcttaa  actcaaagg  cttggcggt  600
ctttatatc  atctagagg  gcctgttct  taatcgata  accccgttc  accttaccc  660
ttctcgcta  ttcagccta  ataccgcca  cttcagcaa  ccctaaaaa  gcactaaag  720
aagcacaag  acaaacata  aaacgttag  tcaaggtgt  gccaatgaa  cggaaagaa  780
tgggctaca  tttcttttc  cagagaaca  tacgaaacc  ttatgaaac  aaaggacaa  840
ggaggattt  gtagtaaat  aagaataga  agcttaatt  aatagagca  tgaagtacg  900
acacaccgc  cgtcaccct  ctcaaatta  attgacatt  acatataca  aatttcact  960
acaaattta  gagaggaga  aagtcgtaa  aaggtaagc  tactggaaa  tgtgcttgg  1020
ataatcaca  tgtagctta  tcacaaagc  tctggccta  acccagaag  attcataaa  1080
aatgaacac  ttgaactaa  cctagccct  caaccaacc  acataacta  acccccaca  1140
aaactaaaa  atttaactc  aaaagtatt  gagaaagaa  tttacttac  aagagctat  1200
gagaaagta  cgcaaggga  atgatgaaa  actaattta  agtaaaaac  agacaaaga  1260
taaacctgt  ccttttgca  aatgaatta  ctagaaaat  cttaacaaa  agaatttaa  1320
ctaagaacc  cgaaaccaa  cgagctacc  aaaaacaat  tcatgaatc  acccgtcta  1380
gtagcaaaa  agtgggaag  tttttaggt  gaggtgaaa  gcctatcga  cttggtgat  1440
gctggttgc  caaaaaaga  tttcagttc  aactttaag  ttccatcag  acaacaaat  1500
aaaatgtaa  cttaaaata  agccaaaag  gggacagct  tttaggaaa  ggaaaaaac  1560
ttaaatagt  aataaacaa  tacaatcac  taaccattg  aggcttaaa  gcaagccat  1620
aataaagaa  gcgtcaagc  acatcatct  acacacaca  taattccac  aacctcaaa  1680
attccaaaa  tacaaattg  gctaaatct  tgatcctag  gaatactgt  aatatgtga  1740
caagaacca  tccaccaag  acaagtgct  agacaaccg  ataaccatt  ttaattatt  1800
aatcatagg  ataacccaa  aatagaatt  cctatccct  actcgttag  ccaacacag  1860
cgtgcttta  ggaaagttt  aaaaagtaa  ggaactcgg  aaacacgaa  cccgcctgt  1920
taccaaaaa  atctcctct  gcataacaa  tattagtgg  atcgcctgc  cagtgacta  1980
agttccacg  ccgcggtat  ccgaccgtg  aaaggtagg  taatcactt  ttccttaat  2040
agggactag  atgaatggc  aaacgaggg  ccaaccgtc  cttacttgc  atcagtgaa  2100
ttgaccttc  agtgaaggg  cggactcat  ataaaagac  agaagaccc  atggagctt  2160
aatttacta  tttcaattt  tataaaaaa  cctaatggg  gaaaacaac  aaattatga  2220
ctaccaaat  tcggttggg  tgacctcgg  gaataaaaa  tcctccgaa  gattataac  2280
gagtcggta  ccgtgtccg  cccagtcaa  taatactaa  atcttattg  cccaattat  2340
gatcaacgg  ccaagttac  ctagggtaa  agcgcgacc  atttaagag  tcatatcga  2400
aattagggt  tacgacctc  atgttggat  aggacatcc  aatggtgca  aagctatta  2460
tggttcgtt  gttcaacga  taaagtcct  cgtgatcta  gtccggcaa  ccaggtcgg  2520
ttctatcta  ttacaattt  tcccagtta  gaaaggaca  gagaaatgg  gaccaacca  2580
tcctaggct  ccaaccaat  tagaaaaac  taataaagt  tatatgtac  ataaataac  2640
ttagaccca  gttattagg  tggcagagc  aagtaattg  gtaagactt  aaaccttgt  2700
cccagaggt  caaatcctc  ccctaatag  gtactttat  aatatccta  cactcctaa  2760
cccaatctt  attgccata  gccttctca  cctagtaga  cggaaaatc  taggctaca  2820
acaattacg  aaaggcccc  acaacgaag  cccatatgg  aaactacaa  catttgcag  2880
tgccataaa  ctattcata  aagaaccca  acgccctct  accacctca  tatcactat  2940
tattatcgc  ccaaccctc  cccttacac  agctctaag  ctatgaatt  ccttaccaa  3000
accccaccc  cttatcaac  tcaacctag  cataccatt  attctagcc  catccagcc  3060
ttcggtcta  tccattcta  gatcgggat  agcctcaaa  tcaaaatac  ccctattcg  3120
agccctacg  gccgttgcc  aaaccatct  ttacgaagt  acaatagcc  tatacctct  3180
atccgtcct  ctaataagc  gctccttct  cctacaaat  cttatcact  cacaagaac  3240
tatctgact  ttaatcccc  cctgaccaa  agccataat  tgatacatt  caaccctcg  3300
agaaacaaa  cgagctccc  tcgacttaa  agaaggaga  tcagaatta  tctcaggct  3360
taacgtcga  tacgccgca  gaccattcg  cctattctt  atagccgag  acaccaaca  3420
tattctaat  aacgcccta  catcaattg  attcctagg  cccttatat  atatcaatt  3480
ccctgaatt  tactcaacc  gcttcataa  agaaacact  cttctatcc  caactttcc  3540
atggattcg  gcatcctac  cccgttttc  atatgacca  ctaatgcac  tcctatgaa  3600
aaatttcct  ccactaaca  tagcattct  catatgata  atttccctg  caattttcc  3660
agcaggaat  ccaccctac  catagaaat  tgtctgaca  aagagttac  ttgatagag  3720
aaataatag  ggtttaaat  ctcttattt  taggacaat  ggaattgaa  ctacaccta  3780
gaattcaaa  ttctccgtg  caccaatac  ccctatcct  catagtaag  tcagctaac  3840
aagctatcg  gcccatacc  cgaaaatgt  ggttaaacc  ttcccgtac  aataaatcc  3900
attacccta  ccattattt  cttaaccac  tttaaaggc  gcctaatca  gacacttag  3960
accaactta  caccaatat  agtaggatt  gaaataagc  ttttagcta  catcccact  4020
ctagccaac  aaaaaagcc  acgatcaac  gaagcagca  caaaatatt  tctaaccca  4080
gctacagcc  caataatta  cctactagt  atcatcctc  actacaaac  atcaggaat  4140
tgaaccctt  aacaacaaa  caataacat  ctactcaac  taatactca  ttcactggc  4200
ataaaactt  gactagccc  attccacta  tgactaccc  aagtcaccc  aggaattcc  4260
ctacacatt  gattaatct  actaacatg  caaaaaatt  ctccactat  aattctata  4320
caattttat  aactcctaa  cccaactat  accaccatt  tcgcaattt  atcagtctt  4380
gttggcgcc  gaggaggac  taaccagac  caaacacga  aaatcatag  atactcatc  4440
attgcccac  taggatgaa  aacagcaat  cttccatac  accctaact  aaccctcct  4500
aacttaaca  tttacatcc  acttactgt  ccaatattc  attacatca  aacaaactc  4560
gcaacaaca  tcaacacac  ctcactcgc  tgaaataaa  ctcccataa  cctaaccat  4620
gcatccatc  tcctcctat  actaggagg  ctcccccct  tcacaggat  tttaccaaa  4680
tgagcaatt  tctccgagc  tctaaaaaa  aactgctca  ccctatcaa  actaatagc  4740
atcatagcc  tattaagcc  attcttcta  actcgacta  tttactcta  atccctcac  4800
acattccca  ccaacaaca  ctccaaaat  atctcccac  accaaaacc  aaaacataa  4860
tttatcctc  caaccctca  agtattaag  accctaacc  taccgcttt  ctcccaact  4920
atcacatag  agtttagga  atacagttc  agagccttc  aagccctta  aaaacaaac  4980
agtttaact  ctgataagg  ctgtaagac  atatcttac  tctgttaaa  gcaaatcaa  5040
tgctttaat  aagctaaat  ctcaactag  ttggaagga  tcaaattcc  acgaaaatt  5100
agttaacag  taaataccc  acttactgg  ttcaatcta  ttctcccgc  tatcagaaa  5160
gaggcggga  aagccttag  agaggagat  ctctacacc  tcgaacttg  aattcgaca  5220
gataatcac  ttaaggctt  ttggtaaaa  gggggctca  cccctgtct  tagatttac  5280
gtctaatgc  tactcagcc  ttttaccta  gttcgtaaa  cgttgactc  tttcaacta  5340
ccacaaaga  atcggaacc  tctacctat  atttggagc  tgagcagga  tagtaggga  5400
agctttgag  attctaatt  gagctgaac  aggacagcc  ggcgcactc  taggagatg  5460
ccaaatcta  aatgtcatc  tcacagccc  tgcattcgt  ataattttc  ttatagtaa  5520
acctataat  attggaggc  tcggaaact  acttgtacc  ctaataatt  gagcccctg  5580
tatagcatt  ccacgaata  ataacataa  cttttgact  cttcctcca  catttctac  5640
ccttttagc  tcctccata  tagaagctg  agctggaac  ggatgaaca  tatatcccc  5700
cttagccgg  aacctagcc  atgctgggg  atccgtaga  ttaactatt  tttccctcc  5760
cctagccgg  gtgtcttct  tcttaggag  tatcaactt  atcaccact  tcattaata  5820
aaaaccccc  gctataacc  aatatcaga  acctctctt  gtatgatcc  tactaatta  5880
agccgtcct  ctacttctc  cactgccag  attagcagc  ggtatcact  tactcctta  5940
agaccgaaa  ctaaatact  ctttcttcg  ccccgctgg  ggtggagac  caattcttt  6000
tcaacacct  ttctgattc  tcggccacc  agaagtgta  atcttaatt  ttccagggt  6060
tggaattat  tcacatgta  ttacctatt  ctctggaaa  aaagaaccc  tcggatata  6120
aggtatggt  tgaaccata  tatctattg  cttcctagg  tttattgta  gagcacatc  6180
catattcac  gtaggccta  atgtagaca  ccgagccta  tttacatct  ccactataa  6240
tatcgcaat  cctacaggc  taaaagtat  cagctgact  gctacacta  atggaggaa  6300
tatcaaatg  tcccccgcc  tattatgag  cttagggtt  atcttctta  tcacagtag  6360
gggcctaac  gggatcgta  tatctaact  atcccttga  attgtactt  atgatacat  6420
ctacgtagt  gctcacttc  actatgtct  atctatagg  gcagtattc  ccatcatag  6480
tggcttcgt  cactgattc  cactattct  aggctatac  ctaaatgac  catgagcaa  6540
agcccactt  gccattata  ttgtaggtg  aaacataac  ttttttcct  aacacttcc  6600
aggattagc  gggatacct  gtcgttact  tgattatcc  gatgcttat  ccacatgaa  6660
tacagtctc  tctataggc  cattcatct  acttacggc  gtccttgta  tgatcttca  6720
gatttgaga  gccttcgca  caaaacgag  agtgctctc  atttcctac  cttcaacta  6780
cctagaatg  ctgcatgga  gccccccac  ttaccacac  ttcgaagaa  cttcctatg  6840
aaaagttaa  taagaaagg  aggaatcga  cccctacaa  tggtttcaa  ccaatttca  6900
aaccattat  tctttctca  tgagatatt  gtaaaataa  tacataacc  tgtcaaggt  6960
aagttatag  cctaatcct  tatatctta  atggcttac  catttcaac  tggcttaca  7020
gacgctaca  cacctatca  agaagaact  acaaacttt  atgaccaca  cctaataat  7080
gtattcctc  tcagctccc  agtacttta  attatttca  taatactaa  aacaaaact  7140
acacacaca  gcacaatag  cgcccaaga  gtagaaaca  tttgaacaa  tctcccagc  7200
gtcattctt  ttctaattg  ccttccctc  ctacgaatt  tatacataa  agacgagat  7260
aataaccca  ttctaacag  aaaaactat  ggacaccaa  gatactgaa  ctatgaata  7320
actgactat  aagacctat  ctttgactc  tacataatc  caaccaatg  cctaaaacc  7380
ggtgaactt  gtctattag  agttgataa  cgggtagtc  taccaatag  acttccaat  7440
cgtatacta  tctcatccg  agacgtcct  cactcatga  ccatccctt  actagggtt  7500
aaaaccgac  caatccccg  ccgcctaaa  caagctaca  tcacatcaa  ccgaccagg  7560
ctattctat  gccaatgct  tgaaatttg  ggctcaaat  acagcttca  acccattgt  7620
ctagaaata  tgcctctaa  atatttcga  aactgatca  cttctataa  ttaaactca  7680
tgcgaagct  agagcgtta  ccttttaag  taaagttag  gacaacaaa  ctccacaat  7740
acatgccac  actagacac  tccacatga  ttattacaa  catctcctc  atagccaca  7800
tatttattt  atttcaatt  aaaatttct  cccaaacct  tcctgcacc  ccctcaccc  7860
aaactatag  cacagaaaa  acgaataac  cttgagaat  aaaatgaac  aaaatctat  7920
tgcctcttt  attaccccc  caataatag  tctaccaat  gttgtgacc  ttattatgt  7980
cccatcaat  ctattccca  catcagaac  cctaatcag  aaccgacta  actcatttc  8040
acactgact  atcaaactt  tcatcaaac  aataatgtt  attcacaca  caaaaggac  8100
aacctgagc  ctaataatt  tatccctaa  tatatttat  ggctcaacc  accttctag  8160
gcttcttcc  catacattt  cccctacca  tcagctatc  atagaccta  gcatagcca  8220
ccccctatg  gcaggagcc  taattctag  tttccgaca  aaactaaaa  attctttag  8280
ccacttctc  ccgcaagga  cccccatct  actaattcc  atactaatc  tcatcgaaa  8340
tatcagcct  tttattcaa  cgatagcac  agcagtacg  ctaacagca  acattacag  8400
aggccatct  ttaatgcat  taatcggag  agctaccct  gtacttata  acatcagcc  8460
accaaccgc  acaattaca  ttattattc  acttctact  acagtactt  aatttgccg  8520
agccttaat  caagcctat  tattcaccc  tctagtcag  ctgtaccta  atgataaca  8580
ataatgacc  accaaaccc  tgcatacca  atagtaaac  caagcccat  accactaac  8640
ggagcccta  cagctcttc  actcacatc  ggcttagta  tatgattcc  ttacaactc  8700
acaattctc  tatcattag  cctcctgac  aacatccta  ctatatatc  atgatgacg  8760
gatatcatc  gtgaaggaa  ataccaagg  caccacacc  ctattgtac  aaaaggcct  8820
cgatacgga  taatcctgt  tattgtctc  gaagtattc  tctttgccg  atttttctg  8880
gcattttat  attccagcc  agttcctac  cacgaccta  gcggttgct  acccccaac  8940
ggaatcacc  ctttaaatc  cctagaagt  ccccttcta  atacatcag  cctcttagc  9000
tcaggagtc  caattacat  agcccatca  agcctaata  aaggcaacc  aaaccatat  9060
aaccaagcc  tactaatca  cattctctt  ggattatat  tcactatct  acaagcctc  9120
gagtatttc  aaacatcat  ttctatctc  gacggaatt  acggctcaa  attcttcat  9180
gcaacggga  ttcatggcc  ccacgtaat  attggctca  ctttcctaa  tgtctgtct  9240
ctacgacaa  taaaattcc  cttcacatc  aaacatcat  tcggatttg  agccgcagc  9300
tgatactga  acttcgtag  tgtagtttg  ctattccta  acgtttcta  ctattgatg  9360
ggatcctac  cccttagta  aaacaatac  actgacttc  aatcagtta  ttctgaaaa  9420
actcagaag  gagtaatta  cctacccat  atcatcaca  ttaacatca  cttatcctt  9480
atcctcatt  caattgcat  ctgattgcc  caaataaac  tatactccg  aaaagcaaa  9540
ccatatgaa  gtggcttcg  cccaacaag  tctgcacgc  ttccttttt  aataaaatt  9600
ttcttagta  ccattacat  tctactatt  gacctagaa  tcgccttac  acttcccct  9660
ccatgagcg  ttcaaacaa  caataccac  acaataata  caactgcct  tattttagt  9720
actattttg  ctcttggcc  agcctacga  tgaacacaa  aaggactag  atgaacaga  9780
taattggta  ttagtttaa  taaaattaa  gatttcgac  cattagatt  tgataataa  9840
cataattac  aacaatgac  tctgctttc  taaatttaa  tatagcctt  acattatct  9900
tactaggta  ttttatatt  cgctcccac  taatatcca  tctcctctg  ctagaagga  9960
taatactat  actatttgt  ataacttca  catccacat  aaactccaa  tccataatc  10020
ccataacca  cccaattac  attctagtt  ttgcagcct  cgaagcagc  gtaggttta  10080
ccttactag  aaaaatttc  aatacttac  gaacagact  cgtacaaaa  ctcaacctt  10140
tacaatgtt  aaaattatt  tcccatcta  catactcct  ccactaaca  gactctcag  10200
caacaaaaa  atctgaacc  atgtcacct  ctacagctt  ctagtgagc  tattaagct  10260
atcactcct  tgacaaaat  acgaaaatt  cctaaattt  tcagttata  tctcctccg  10320
tccattatc  accccacta  tcattctaa  aacttgact  ctcccacta  taatgctcg  10380
tagccaaaa  cacataaaa  aagaaaata  aatgcatca  aaactttac  tctcaatac  10440
tattagcct  caaatttta  tcatcataa  attctccgc  acagaacta  ttttatttt  10500
tatcctgtt  gaggccact  taatcccaa  actaattat  attacacga  gaggcaacc  10560
aacagaacg  ttaaatgca  gaatttatt  cctgtttta  acactaatt  gctccatcc  10620
actcttaat  gccctcatt  caatccaaa  ctcaatagg  acactcaac  tcctaatcc  10680
ttccctcac  acacacccc  taccctcaa  atgatccaa  accattcta  gactagcat  10740
tataatagc  tttataatc  aaataccat  atacggagt  catctatga  taccaaaag  10800
ccacgtaga  gctccaatt  caggctcta  aattttagc  gcaattctc  taaagctag  10860
gggttatgg  ataatacga  tttccatca  tctagaccc  ctaacaaaa  ctttagcct  10920
cccattcat  atcctctca  tatgaggca  aattataac  agctcaatc  gcctacgcc  10980
aacagatct  aaatcatta  ttgcttact  atcagtaag  catatagcc  tagtcatca  11040
agccattat  atccagaca  catgaagct  catgggagc  acaatacta  taatcgccc  11100
cggcttaac  tcatcactc  tattctgcc  agcaaacac  aactacgaa  gaattcaca  11160
ccgaactat  attatagct  gaggattac  aataatctt  ccattgata  caacatgat  11220
actattagc  agcttagcc  acctagcac  accacccct  attaacctc  taggcgagt  11280
attcattgt  atagcaaca  tttcctgat  gaacccctc  atcatcctt  tagcaacta  11340
cattgtcat  acaggaata  actcaatat  tatgattat  acaacccaa  gaggaaaac  11400
aaccagcca  ataaacaac  tccaacctt  ccacacacg  gaattaaca  tcatagctc  11460
acacattat  cccctcata  tattaacaa  caaccctaa  ctcatcaca  gcctaacaa  11520
atgtagata  agtttacaa  aaacattag  ctgtgaatc  aacaacagg  aatcaaatt  11580
cttatttac  aagaaagta  gcaagaact  ctaattcat  cacccatac  taaaacata  11640
ggctttctt  cttttatag  atagaagta  tccattggt  ttaggaacc  aaaaccttg  11700
tgcaactcc  aataaaagt  ataaatata  taacaatcc  aatcctcat  attcttgat  11760
tacttacaa  accaatcac  ttttcaata  caatcttaa  caaacttat  tacttccgt  11820
atatgctca  tacatcaat  aaattctca  tcctcctta  cctcttacc  ttactacta  11880
tcttccacc  caacacaga  tacataatt  ctaactgac  ttgactaac  attaattct  11940
ttaaactta  tataagttt  aaaattgac  atttctcaa  cctattcct  tcagtatcc  12000
tattcgtaa  atgatcaat  atacaattc  cttcatgat  tatacactc  gacccccac  12060
ttaaccgat  cattaagta  ttaataata  tcctgaata  catactaat  ctaacctca  12120
ctaacaatc  attccaact  tttattgga  gagaagggg  aggaattat  tccttctta  12180
taatcggat  atgatatgg  cttgcagac  ccaacacag  ggccctcca  gcaatcctc  12240
acaaccgag  cggagacat  ggtttcatc  tagctataa  ctgattctg  ctaaacata  12300
actcctgag  actccaaca  attttctta  ccaacacca  caacaatct  gtccctctc  12360
caggactac  aattgcagc  acaggaaaa  ccgcccaat  cggacttca  ccatgactc  12420
catcagcta  agaaggccc  actcccgtc  ctgccctac  acactcaag  acaatagtt  12480
tagcaggga  cttcctaat  atccgattc  accccctaa  ctcaaacaa  agtactatt  12540
taacagcca  actatgtct  ggtgcaatc  ccacattat  cacagcaat  tgtgctctc  12600
cccaaaacg  catcaaaaa  atcgtagct  tctcaacat  cagccaact  ggccttata  12660
tagtcacat  agggattaa  caaccctac  ttgctttcc  ccacatttg  acccatgca  12720
tcttcaaag  catattatt  atatgctcc  gatcaatca  ccatatcct  aacgatgaa  12780
aagacattc  aaaaatagg  aatataata  aagcaatac  attcacatc  tcttgtctc  12840
ttatcggaa  cctagccct  accggaata  ctttcctca  aggattcta  tcaaaagat  12900
tcatcatcg  agccatcaa  acgtgtaac  ccaacgcct  agccctaat  atcacttta  12960
tcgccacat  cataactgc  gtgtacagc  tacggatca  ctacttcgt  accatgaca  13020
aaccacgat  ctccccact  attactatt  atgaaaaca  cccaaacct  attaatcca  13080
tcaaacgcc  agcattagg  agcatccta  caggcttcc  tatctcact  aatattcct  13140
caactaaca  tcaaattct  acaataccc  gacatttaa  aataacagc  ctacttatt  13200
caatcctag  atttgccat  gccctagaa  ttaacaatt  aacactaaa  ctatcaata  13260
gcaaaccca  caaactatc  tcattctca  cctccctag  ctactaccc  ccaattata  13320
cccgaatta  tcctcaaaa  actctaaat  ctagctaca  attatcctt  aacctacta  13380
acctaatct  atcagaaaa  acaatccca  aatcaacct  aatcaccca  acccaacta  13440
ctaaaataa  atccaacca  aaaggacta  tcaaactat  tttcctatc  tttctcatc  13500
ctatttcac  aatttttat  ttacacaca  ttaatcccg  gtgatttca  taataataa  13560
aatccccgc  aacaatgac  acccagcca  cactatcat  caagtagca  aactataaa  13620
agccgcaac  ccaatcccc  cctccaaca  aaccccaac  tcatcaatc  catacatta  13680
tcaatcgcc  agactatca  aatcaacta  ctccacctt  ttattcaaa  taaacaagt  13740
gaacactac  aactccata  aaagcccta  aacaaaaaa  ctaaaaata  accaattag  13800
ccctcaagt  tccggatat  cctcagtag  catagcagt  gtataccca  atacaacca  13860
catcccacc  aaataaatt  aaaatacta  taaacctaa  aacgaaccc  caaacccta  13920
aactattaa  cacccaata  atccactaa  aatcaatcc  aacccacca  aaataggtg  13980
aggcttcaa  gccaaccct  gacaaccag  caaaaacag  aaacttaaa  taaacatat  14040
atttgtcat  atttctaca  agcatttaa  tgtgactaa  gacatgaaa  atcatcgtt  14100
taattcaac  atagaaaca  ctaatgaca  acatccgaa  atctcaccc  ctattcaaa  14160
tcatcaacc  ctcctttat  gacctaccg  ccccatcta  catctcatc  tgatgaaac  14220
tcggttctc  actaggagt  tgcctcata  tacaaatcc  cacaggctt  ttcctagca  14280
tacactaca  gtctgatac  ataacagca  tctcatcag  cacccacat  tgccgagac  14340
taaactacg  ctgactaat  cgataccta  aagccaacg  cgcctcaat  tttttcatc  14400
gcctattcc  ccatgtggg  cgaggacta  actatggat  ctacacttt  ctagaaacc  14460
gaaacattg  gatcatcct  ctatttgca  tcatagcaa  tgcattcat  ggctatgta  14520
tcccatgag  acaaatatc  ttctgagga  ctacagtaa  tacaaacct  ttatcagct  14580
tcccttaca  tgggactac  ctagtcgaa  gaatctgag  aggcttctc  gtagacaaa  14640
caaccctaa  acgcttctt  gcattccac  tcatcctcc  attcattat  gccgccctt  14700
caattgtac  tcttctttt  ctccacgaa  caggatcaa  taaccccac  ggattaaac  14760
ccgacgcag  caaaatccc  ttccatcca  attatacaa  taaagacct  ctaggtgta  14820
ttatattac  attattcct  ataacccta  tactattct  cccagacct  ctaggagac  14880
cagacaatt  tacacccgc  aaccccctc  acaccccac  ccacatcaa  ccagaatga  14940
actttctct  tgcctacgc  attctacgc  ccattccca  caaactagg  ggggtcgta  15000
ccctaatct  atcaatcct  atcttagcc  tcctaccat  cctgcatac  tcaaaacaa  15060
gcagcttaa  attccgccc  atcacccaa  tcctttact  aatcctagt  gccaacctc  15120
tagtcttaa  atgaatcgg  ggccaacca  tagaacacc  atttatcat  attggtcaa  15180
tagcctcca  cagttattt  tcaattatc  tcattctca  accaatctc  ggaattgtt  15240
aagacaaaa  gttaaaatg  aattaatgt  ccgatagta  aaaaattac  ctggtcttg  15300
aaaccaaaa  tgaagagtc  gtcttctca  gacaatcaa  aagaaggaa  tacctcccc  15360
ccatcaaca  ccaaagctg  tattctact  aaactactt  ttgtcagta  ataaaatga  15420
atggacatt  aaacattta  gtatatcgt  cattaaatt  ttttcccca  gcatataag  15480
atgtaatat  tatctaatg  tttaggaca  acatttaaa  tcaactata  attcacaac  15540
acatgtcta  tctcaaata  attaagata  tgcttatta  acatatctg  gttattaga  15600
atgcaccat  aagtcataa  cctttctct  ccatatgac  atccctgtc  ccaattggt  15660
tctatttct  ccatcctcc  tgaaatcaa  aacccgccc  ctcgtcccc  tcttctcgc  15720
ccgggccca  tcgtcctgg  ggtgactat  ctgaaactt  accaggcat  tggttctta  15780
ttcagggcc  tcaattggt  catcgtcca  acgttcccc  taaataaga  atctcgatg  15840
taacgggtc  aatcagccc  tgatcaaca  aactgtggt  atatacatt  ggtattttt  15900
aattttcgg  tgccttcct  aacatagcc  tcaaggcat  aaggtcagc  caaagtcct  15960
tggaacctt  tagttaagg  tcatttatc  tcatagaca  agctcgaaa  actatttta  16020
tcatgtttg  aagacataa  tatttataa  tactgaaaa  tctgtcaac  aaccccccc  16080
ccccctaca  ctgaaactt  aatgccaaa  cccaaaaac  ttaaagcaa  aattaaata  16140
aacaaaaag  tacttaatt  ttaaaaggc  tctccattc  agtagacca  aaaatttta  16200
cttaaatct  agcattggt  aaatttccc  acacaaaat  tttcctcct  actaaaccc  16260
ctttacttg  ctaccctca  aaaattcca  atacaccaaa  16300



<210> 9425
<211> 16300
<212> DNA
<213> Rattus norvegicus
<308> X14848
<400> 9425

gttaatgta  cttataata  agcaaagca  tgaaaatgc  tagatggat  caaaaatcc  60
ataaacaca  aggtttggt  ctggcctta  aattaattg  aggtaagat  acacatgca  120
acatccata  accggtgta  aatccctta  agatttgcc  aaaacttaa  gagagggca  180
caagcacat  atatagctc  agacgcctt  cctagccac  cccccacgg  actcagcag  240
gataaatat  aagcaatga  cgaaagttt  actaagcta  tacctctca  ggttggtaa  300
tttcgtgcc  gccaccgcg  tcatacgat  aacccaaac  aattatttt  ggcgtaaaa  360
gtgccaact  taaatctca  aatagaatt  aaatccaac  tatatgtga  aattcattg  420
taggaccta  gcccaataa  gaaagtaat  ctaatcatt  atataatgc  cgatagcta  480
gacccaaac  gggattaga  accccacta  gcttagccc  aaaccttaa  aattaaacc  540
acaaaatta  ttgccagag  actactagc  acagcttaa  actcaaagg  cttggcggt  600
ctttatatc  atctagagg  gcctgttct  taatcgata  accccgttc  accttaccc  660
ttctcgcta  ttcagccta  ataccgcca  cttcagcaa  ccctaaaaa  gcactaaag  720
aagcacaag  acaaacata  aaacgttag  tcaaggtgt  gccaatgaa  cggaaagaa  780
tgggctaca  tttcttttc  cagagaaca  tacgaaacc  ttatgaaac  aaaggacaa  840
ggaggattt  gtagtaaat  aagaataga  agcttaatt  aatagagca  tgaagtacg  900
acacaccgc  cgtcaccct  ctcaaatta  attgacatt  acatataca  aatttcact  960
acaaattta  gagaggaga  aagtcgtaa  aaggtaagc  tactggaaa  tgtgcttgg  1020
ataatcaca  tgtagctta  tcacaaagc  tctggccta  acccagaag  attcataaa  1080
aatgaacac  ttgaactaa  cctagccct  caaccaacc  acataacta  acccccaca  1140
aaactaaaa  atttaactc  aaaagtatt  gagaaagaa  tttacttac  aagagctat  1200
gagaaagta  cgcaaggga  atgatgaaa  actaattta  agtaaaaac  agacaaaga  1260
taaacctgt  ccttttgca  aatgaatta  ctagaaaat  cttaacaaa  agaatttaa  1320
ctaagaacc  cgaaaccaa  cgagctacc  aaaaacaat  tcatgaatc  acccgtcta  1380
gtagcaaaa  agtgggaag  tttttaggt  gaggtgaaa  gcctatcga  cttggtgat  1440
gctggttgc  caaaaaaga  tttcagttc  aactttaag  ttccatcag  acaacaaat  1500
aaaatgtaa  cttaaaata  agccaaaag  gggacagct  tttaggaaa  ggaaaaaac  1560
ttaaatagt  aataaacaa  tacaatcac  taaccattg  aggcttaaa  gcaagccat  1620
aataaagaa  gcgtcaagc  acatcatct  acacacaca  taattccac  aacctcaaa  1680
attccaaaa  tacaaattg  gctaaatct  tgatcctag  gaatactgt  aatatgtga  1740
caagaacca  tccaccaag  acaagtgct  agacaaccg  ataaccatt  ttaattatt  1800
aatcatagg  ataacccaa  aatagaatt  cctatccct  actcgttag  ccaacacag  1860
cgtgcttta  ggaaagttt  aaaaagtaa  ggaactcgg  aaacacgaa  cccgcctgt  1920
taccaaaaa  atctcctct  gcataacaa  tattagtgg  atcgcctgc  cagtgacta  1980
agttccacg  ccgcggtat  ccgaccgtg  aaaggtagg  taatcactt  ttccttaat  2040
agggactag  atgaatggc  aaacgaggg  ccaaccgtc  cttacttgc  atcagtgaa  2100
ttgaccttc  agtgaaggg  cggactcat  ataaaagac  agaagaccc  atggagctt  2160
aatttacta  tttcaattt  tataaaaaa  cctaatggg  gaaaacaac  aaattatga  2220
ctaccaaat  tcggttggg  tgacctcgg  gaataaaaa  tcctccgaa  gattataac  2280
gagtcggta  ccgtgtccg  cccagtcaa  taatactaa  atcttattg  cccaattat  2340
gatcaacgg  ccaagttac  ctagggtaa  agcgcgacc  atttaagag  tcatatcga  2400
aattagggt  tacgacctc  atgttggat  aggacatcc  aatggtgca  aagctatta  2460
tggttcgtt  gttcaacga  taaagtcct  cgtgatcta  gtccggcaa  ccaggtcgg  2520
ttctatcta  ttacaattt  tcccagtta  gaaaggaca  gagaaatgg  gaccaacca  2580
tcctaggct  ccaaccaat  tagaaaaac  taataaagt  tatatgtac  ataaataac  2640
ttagaccca  gttattagg  tggcagagc  aagtaattg  gtaagactt  aaaccttgt  2700
cccagaggt  caaatcctc  ccctaatag  gtactttat  aatatccta  cactcctaa  2760
cccaatctt  attgccata  gccttctca  cctagtaga  cggaaaatc  taggctaca  2820
acaattacg  aaaggcccc  acaacgaag  cccatatgg  aaactacaa  catttgcag  2880
tgccataaa  ctattcata  aagaaccca  acgccctct  accacctca  tatcactat  2940
tattatcgc  ccaaccctc  cccttacac  agctctaag  ctatgaatt  ccttaccaa  3000
accccaccc  cttatcaac  tcaacctag  cataccatt  attctagcc  catccagcc  3060
ttcggtcta  tccattcta  gatcgggat  agcctcaaa  tcaaaatac  ccctattcg  3120
agccctacg  gccgttgcc  aaaccatct  ttacgaagt  acaatagcc  tatacctct  3180
atccgtcct  ctaataagc  gctccttct  cctacaaat  cttatcact  cacaagaac  3240
tatctgact  ttaatcccc  cctgaccaa  agccataat  tgatacatt  caaccctcg  3300
agaaacaaa  cgagctccc  tcgacttaa  agaaggaga  tcagaatta  tctcaggct  3360
taacgtcga  tacgccgca  gaccattcg  cctattctt  atagccgag  acaccaaca  3420
tattctaat  aacgcccta  catcaattg  attcctagg  cccttatat  atatcaatt  3480
ccctgaatt  tactcaacc  gcttcataa  agaaacact  cttctatcc  caactttcc  3540
atggattcg  gcatcctac  cccgttttc  atatgacca  ctaatgcac  tcctatgaa  3600
aaatttcct  ccactaaca  tagcattct  catatgata  atttccctg  caattttcc  3660
agcaggaat  ccaccctac  catagaaat  tgtctgaca  aagagttac  ttgatagag  3720
aaataatag  ggtttaaat  ctcttattt  taggacaat  ggaattgaa  ctacaccta  3780
gaattcaaa  ttctccgtg  caccaatac  ccctatcct  catagtaag  tcagctaac  3840
aagctatcg  gcccatacc  cgaaaatgt  ggttaaacc  ttcccgtac  aataaatcc  3900
attacccta  ccattattt  cttaaccac  tttaaaggc  gcctaatca  gacacttag  3960
accaactta  caccaatat  agtaggatt  gaaataagc  ttttagcta  catcccact  4020
ctagccaac  aaaaaagcc  acgatcaac  gaagcagca  caaaatatt  tctaaccca  4080
gctacagcc  caataatta  cctactagt  atcatcctc  actacaaac  atcaggaat  4140
tgaaccctt  aacaacaaa  caataacat  ctactcaac  taatactca  ttcactggc  4200
ataaaactt  gactagccc  attccacta  tgactaccc  aagtcaccc  aggaattcc  4260
ctacacatt  gattaatct  actaacatg  caaaaaatt  ctccactat  aattctata  4320
caattttat  aactcctaa  cccaactat  accaccatt  tcgcaattt  atcagtctt  4380
gttggcgcc  gaggaggac  taaccagac  caaacacga  aaatcatag  atactcatc  4440
attgcccac  taggatgaa  aacagcaat  cttccatac  accctaact  aaccctcct  4500
aacttaaca  tttacatcc  acttactgt  ccaatattc  attacatca  aacaaactc  4560
gcaacaaca  tcaacacac  ctcactcgc  tgaaataaa  ctcccataa  cctaaccat  4620
gcatccatc  tcctcctat  actaggagg  ctcccccct  tcacaggat  tttaccaaa  4680
tgagcaatt  tctccgagc  tctaaaaaa  aactgctca  ccctatcaa  actaatagc  4740
atcatagcc  tattaagcc  attcttcta  actcgacta  tttactcta  atccctcac  4800
acattccca  ccaacaaca  ctccaaaat  atctcccac  accaaaacc  aaaacataa  4860
tttatcctc  caaccctca  agtattaag  accctaacc  taccgcttt  ctcccaact  4920
atcacatag  agtttagga  atacagttc  agagccttc  aagccctta  aaaacaaac  4980
agtttaact  ctgataagg  ctgtaagac  atatcttac  tctgttaaa  gcaaatcaa  5040
tgctttaat  aagctaaat  ctcaactag  ttggaagga  tcaaattcc  acgaaaatt  5100
agttaacag  taaataccc  acttactgg  ttcaatcta  ttctcccgc  tatcagaaa  5160
gaggcggga  aagccttag  agaggagat  ctctacacc  tcgaacttg  aattcgaca  5220
gataatcac  ttaaggctt  ttggtaaaa  gggggctca  cccctgtct  tagatttac  5280
gtctaatgc  tactcagcc  ttttaccta  gttcgtaaa  cgttgactc  tttcaacta  5340
ccacaaaga  atcggaacc  tctacctat  atttggagc  tgagcagga  tagtaggga  5400
agctttgag  attctaatt  gagctgaac  aggacagcc  ggcgcactc  taggagatg  5460
ccaaatcta  aatgtcatc  tcacagccc  tgcattcgt  ataattttc  ttatagtaa  5520
acctataat  attggaggc  tcggaaact  acttgtacc  ctaataatt  gagcccctg  5580
tatagcatt  ccacgaata  ataacataa  cttttgact  cttcctcca  catttctac  5640
ccttttagc  tcctccata  tagaagctg  agctggaac  ggatgaaca  tatatcccc  5700
cttagccgg  aacctagcc  atgctgggg  atccgtaga  ttaactatt  tttccctcc  5760
cctagccgg  gtgtcttct  tcttaggag  tatcaactt  atcaccact  tcattaata  5820
aaaaccccc  gctataacc  aatatcaga  acctctctt  gtatgatcc  tactaatta  5880
agccgtcct  ctacttctc  cactgccag  attagcagc  ggtatcact  tactcctta  5940
agaccgaaa  ctaaatact  ctttcttcg  ccccgctgg  ggtggagac  caattcttt  6000
tcaacacct  ttctgattc  tcggccacc  agaagtgta  atcttaatt  ttccagggt  6060
tggaattat  tcacatgta  ttacctatt  ctctggaaa  aaagaaccc  tcggatata  6120
aggtatggt  tgaaccata  tatctattg  cttcctagg  tttattgta  gagcacatc  6180
catattcac  gtaggccta  atgtagaca  ccgagccta  tttacatct  ccactataa  6240
tatcgcaat  cctacaggc  taaaagtat  cagctgact  gctacacta  atggaggaa  6300
tatcaaatg  tcccccgcc  tattatgag  cttagggtt  atcttctta  tcacagtag  6360
gggcctaac  gggatcgta  tatctaact  atcccttga  attgtactt  atgatacat  6420
ctacgtagt  gctcacttc  actatgtct  atctatagg  gcagtattc  ccatcatag  6480
tggcttcgt  cactgattc  cactattct  aggctatac  ctaaatgac  catgagcaa  6540
agcccactt  gccattata  ttgtaggtg  aaacataac  ttttttcct  aacacttcc  6600
aggattagc  gggatacct  gtcgttact  tgattatcc  gatgcttat  ccacatgaa  6660
tacagtctc  tctataggc  cattcatct  acttacggc  gtccttgta  tgatcttca  6720
gatttgaga  gccttcgca  caaaacgag  agtgctctc  atttcctac  cttcaacta  6780
cctagaatg  ctgcatgga  gccccccac  ttaccacac  ttcgaagaa  cttcctatg  6840
aaaagttaa  taagaaagg  aggaatcga  cccctacaa  tggtttcaa  ccaatttca  6900
aaccattat  tctttctca  tgagatatt  gtaaaataa  tacataacc  tgtcaaggt  6960
aagttatag  cctaatcct  tatatctta  atggcttac  catttcaac  tggcttaca  7020
gacgctaca  cacctatca  agaagaact  acaaacttt  atgaccaca  cctaataat  7080
gtattcctc  tcagctccc  agtacttta  attatttca  taatactaa  aacaaaact  7140
acacacaca  gcacaatag  cgcccaaga  gtagaaaca  tttgaacaa  tctcccagc  7200
gtcattctt  ttctaattg  ccttccctc  ctacgaatt  tatacataa  agacgagat  7260
aataaccca  ttctaacag  aaaaactat  ggacaccaa  gatactgaa  ctatgaata  7320
actgactat  aagacctat  ctttgactc  tacataatc  caaccaatg  cctaaaacc  7380
ggtgaactt  gtctattag  agttgataa  cgggtagtc  taccaatag  acttccaat  7440
cgtatacta  tctcatccg  agacgtcct  cactcatga  ccatccctt  actagggtt  7500
aaaaccgac  caatccccg  ccgcctaaa  caagctaca  tcacatcaa  ccgaccagg  7560
ctattctat  gccaatgct  tgaaatttg  ggctcaaat  acagcttca  acccattgt  7620
ctagaaata  tgcctctaa  atatttcga  aactgatca  cttctataa  ttaaactca  7680
tgcgaagct  agagcgtta  ccttttaag  taaagttag  gacaacaaa  ctccacaat  7740
acatgccac  actagacac  tccacatga  ttattacaa  catctcctc  atagccaca  7800
tatttattt  atttcaatt  aaaatttct  cccaaacct  tcctgcacc  ccctcaccc  7860
aaactatag  cacagaaaa  acgaataac  cttgagaat  aaaatgaac  aaaatctat  7920
tgcctcttt  attaccccc  caataatag  tctaccaat  gttgtgacc  ttattatgt  7980
cccatcaat  ctattccca  catcagaac  cctaatcag  aaccgacta  actcatttc  8040
acactgact  atcaaactt  tcatcaaac  aataatgtt  attcacaca  caaaaggac  8100
aacctgagc  ctaataatt  tatccctaa  tatatttat  ggctcaacc  accttctag  8160
gcttcttcc  catacattt  cccctacca  tcagctatc  atagaccta  gcatagcca  8220
ccccctatg  gcaggagcc  taattctag  tttccgaca  aaactaaaa  attctttag  8280
ccacttctc  ccgcaagga  cccccatct  actaattcc  atactaatc  tcatcgaaa  8340
tatcagcct  tttattcaa  cgatagcac  agcagtacg  ctaacagca  acattacag  8400
aggccatct  ttaatgcat  taatcggag  agctaccct  gtacttata  acatcagcc  8460
accaaccgc  acaattaca  ttattattc  acttctact  acagtactt  aatttgccg  8520
agccttaat  caagcctat  tattcaccc  tctagtcag  ctgtaccta  atgataaca  8580
ataatgacc  accaaaccc  tgcatacca  atagtaaac  caagcccat  accactaac  8640
ggagcccta  cagctcttc  actcacatc  ggcttagta  tatgattcc  ttacaactc  8700
acaattctc  tatcattag  cctcctgac  aacatccta  ctatatatc  atgatgacg  8760
gatatcatc  gtgaaggaa  ataccaagg  caccacacc  ctattgtac  aaaaggcct  8820
cgatacgga  taatcctgt  tattgtctc  gaagtattc  tctttgccg  atttttctg  8880
gcattttat  attccagcc  agttcctac  cacgaccta  gcggttgct  acccccaac  8940
ggaatcacc  ctttaaatc  cctagaagt  ccccttcta  atacatcag  cctcttagc  9000
tcaggagtc  caattacat  agcccatca  agcctaata  aaggcaacc  aaaccatat  9060
aaccaagcc  tactaatca  cattctctt  ggattatat  tcactatct  acaagcctc  9120
gagtatttc  aaacatcat  ttctatctc  gacggaatt  acggctcaa  attcttcat  9180
gcaacggga  ttcatggcc  ccacgtaat  attggctca  ctttcctaa  tgtctgtct  9240
ctacgacaa  taaaattcc  cttcacatc  aaacatcat  tcggatttg  agccgcagc  9300
tgatactga  acttcgtag  tgtagtttg  ctattccta  acgtttcta  ctattgatg  9360
ggatcctac  cccttagta  aaacaatac  actgacttc  aatcagtta  ttctgaaaa  9420
actcagaag  gagtaatta  cctacccat  atcatcaca  ttaacatca  cttatcctt  9480
atcctcatt  caattgcat  ctgattgcc  caaataaac  tatactccg  aaaagcaaa  9540
ccatatgaa  gtggcttcg  cccaacaag  tctgcacgc  ttccttttt  aataaaatt  9600
ttcttagta  ccattacat  tctactatt  gacctagaa  tcgccttac  acttcccct  9660
ccatgagcg  ttcaaacaa  caataccac  acaataata  caactgcct  tattttagt  9720
actattttg  ctcttggcc  agcctacga  tgaacacaa  aaggactag  atgaacaga  9780
taattggta  ttagtttaa  taaaattaa  gatttcgac  cattagatt  tgataataa  9840
cataattac  aacaatgac  tctgctttc  taaatttaa  tatagcctt  acattatct  9900
tactaggta  ttttatatt  cgctcccac  taatatcca  tctcctctg  ctagaagga  9960
taatactat  actatttgt  ataacttca  catccacat  aaactccaa  tccataatc  10020
ccataacca  cccaattac  attctagtt  ttgcagcct  cgaagcagc  gtaggttta  10080
ccttactag  aaaaatttc  aatacttac  gaacagact  cgtacaaaa  ctcaacctt  10140
tacaatgtt  aaaattatt  tcccatcta  catactcct  ccactaaca  gactctcag  10200
caacaaaaa  atctgaacc  atgtcacct  ctacagctt  ctagtgagc  tattaagct  10260
atcactcct  tgacaaaat  acgaaaatt  cctaaattt  tcagttata  tctcctccg  10320
tccattatc  accccacta  tcattctaa  aacttgact  ctcccacta  taatgctcg  10380
tagccaaaa  cacataaaa  aagaaaata  aatgcatca  aaactttac  tctcaatac  10440
tattagcct  caaatttta  tcatcataa  attctccgc  acagaacta  ttttatttt  10500
tatcctgtt  gaggccact  taatcccaa  actaattat  attacacga  gaggcaacc  10560
aacagaacg  ttaaatgca  gaatttatt  cctgtttta  acactaatt  gctccatcc  10620
actcttaat  gccctcatt  caatccaaa  ctcaatagg  acactcaac  tcctaatcc  10680
ttccctcac  acacacccc  taccctcaa  atgatccaa  accattcta  gactagcat  10740
tataatagc  tttataatc  aaataccat  atacggagt  catctatga  taccaaaag  10800
ccacgtaga  gctccaatt  caggctcta  aattttagc  gcaattctc  taaagctag  10860
gggttatgg  ataatacga  tttccatca  tctagaccc  ctaacaaaa  ctttagcct  10920
cccattcat  atcctctca  tatgaggca  aattataac  agctcaatc  gcctacgcc  10980
aacagatct  aaatcatta  ttgcttact  atcagtaag  catatagcc  tagtcatca  11040
agccattat  atccagaca  catgaagct  catgggagc  acaatacta  taatcgccc  11100
cggcttaac  tcatcactc  tattctgcc  agcaaacac  aactacgaa  gaattcaca  11160
ccgaactat  attatagct  gaggattac  aataatctt  ccattgata  caacatgat  11220
actattagc  agcttagcc  acctagcac  accacccct  attaacctc  taggcgagt  11280
attcattgt  atagcaaca  tttcctgat  gaacccctc  atcatcctt  tagcaacta  11340
cattgtcat  acaggaata  actcaatat  tatgattat  acaacccaa  gaggaaaac  11400
aaccagcca  ataaacaac  tccaacctt  ccacacacg  gaattaaca  tcatagctc  11460
acacattat  cccctcata  tattaacaa  caaccctaa  ctcatcaca  gcctaacaa  11520
atgtagata  agtttacaa  aaacattag  ctgtgaatc  aacaacagg  aatcaaatt  11580
cttatttac  aagaaagta  gcaagaact  ctaattcat  cacccatac  taaaacata  11640
ggctttctt  cttttatag  atagaagta  tccattggt  ttaggaacc  aaaaccttg  11700
tgcaactcc  aataaaagt  ataaatata  taacaatcc  aatcctcat  attcttgat  11760
tacttacaa  accaatcac  ttttcaata  caatcttaa  caaacttat  tacttccgt  11820
atatgctca  tacatcaat  aaattctca  tcctcctta  cctcttacc  ttactacta  11880
tcttccacc  caacacaga  tacataatt  ctaactgac  ttgactaac  attaattct  11940
ttaaactta  tataagttt  aaaattgac  atttctcaa  cctattcct  tcagtatcc  12000
tattcgtaa  atgatcaat  atacaattc  cttcatgat  tatacactc  gacccccac  12060
ttaaccgat  cattaagta  ttaataata  tcctgaata  catactaat  ctaacctca  12120
ctaacaatc  attccaact  tttattgga  gagaagggg  aggaattat  tccttctta  12180
taatcggat  atgatatgg  cttgcagac  ccaacacag  ggccctcca  gcaatcctc  12240
acaaccgag  cggagacat  ggtttcatc  tagctataa  ctgattctg  ctaaacata  12300
actcctgag  actccaaca  attttctta  ccaacacca  caacaatct  gtccctctc  12360
caggactac  aattgcagc  acaggaaaa  ccgcccaat  cggacttca  ccatgactc  12420
catcagcta  agaaggccc  actcccgtc  ctgccctac  acactcaag  acaatagtt  12480
tagcaggga  cttcctaat  atccgattc  accccctaa  ctcaaacaa  agtactatt  12540
taacagcca  actatgtct  ggtgcaatc  ccacattat  cacagcaat  tgtgctctc  12600
cccaaaacg  catcaaaaa  atcgtagct  tctcaacat  cagccaact  ggccttata  12660
tagtcacat  agggattaa  caaccctac  ttgctttcc  ccacatttg  acccatgca  12720
tcttcaaag  catattatt  atatgctcc  gatcaatca  ccatatcct  aacgatgaa  12780
aagacattc  aaaaatagg  aatataata  aagcaatac  attcacatc  tcttgtctc  12840
ttatcggaa  cctagccct  accggaata  ctttcctca  aggattcta  tcaaaagat  12900
tcatcatcg  agccatcaa  acgtgtaac  ccaacgcct  agccctaat  atcacttta  12960
tcgccacat  cataactgc  gtgtacagc  tacggatca  ctacttcgt  accatgaca  13020
aaccacgat  ctccccact  attactatt  atgaaaaca  cccaaacct  attaatcca  13080
tcaaacgcc  agcattagg  agcatccta  caggcttcc  tatctcact  aatattcct  13140
caactaaca  tcaaattct  acaataccc  gacatttaa  aataacagc  ctacttatt  13200
caatcctag  atttgccat  gccctagaa  ttaacaatt  aacactaaa  ctatcaata  13260
gcaaaccca  caaactatc  tcattctca  cctccctag  ctactaccc  ccaattata  13320
cccgaatta  tcctcaaaa  actctaaat  ctagctaca  attatcctt  aacctacta  13380
acctaatct  atcagaaaa  acaatccca  aatcaacct  aatcaccca  acccaacta  13440
ctaaaataa  atccaacca  aaaggacta  tcaaactat  tttcctatc  tttctcatc  13500
ctatttcac  aatttttat  ttacacaca  ttaatcccg  gtgatttca  taataataa  13560
aatccccgc  aacaatgac  acccagcca  cactatcat  caagtagca  aactataaa  13620
agccgcaac  ccaatcccc  cctccaaca  aaccccaac  tcatcaatc  catacatta  13680
tcaatcgcc  agactatca  aatcaacta  ctccacctt  ttattcaaa  taaacaagt  13740
gaacactac  aactccata  aaagcccta  aacaaaaaa  ctaaaaata  accaattag  13800
ccctcaagt  tccggatat  cctcagtag  catagcagt  gtataccca  atacaacca  13860
catcccacc  aaataaatt  aaaatacta  taaacctaa  aacgaaccc  caaacccta  13920
aactattaa  cacccaata  atccactaa  aatcaatcc  aacccacca  aaataggtg  13980
aggcttcaa  gccaaccct  gacaaccag  caaaaacag  aaacttaaa  taaacatat  14040
atttgtcat  atttctaca  agcatttaa  tgtgactaa  gacatgaaa  atcatcgtt  14100
taattcaac  atagaaaca  ctaatgaca  acatccgaa  atctcaccc  ctattcaaa  14160
tcatcaacc  ctcctttat  gacctaccg  ccccatcta  catctcatc  tgatgaaac  14220
tcggttctc  actaggagt  tgcctcata  tacaaatcc  cacaggctt  ttcctagca  14280
tacactaca  gtctgatac  ataacagca  tctcatcag  cacccacat  tgccgagac  14340
taaactacg  ctgactaat  cgataccta  aagccaacg  cgcctcaat  tttttcatc  14400
gcctattcc  ccatgtggg  cgaggacta  actatggat  ctacacttt  ctagaaacc  14460
gaaacattg  gatcatcct  ctatttgca  tcatagcaa  tgcattcat  ggctatgta  14520
tcccatgag  acaaatatc  ttctgagga  ctacagtaa  tacaaacct  ttatcagct  14580
tcccttaca  tgggactac  ctagtcgaa  gaatctgag  aggcttctc  gtagacaaa  14640
caaccctaa  acgcttctt  gcattccac  tcatcctcc  attcattat  gccgccctt  14700
caattgtac  tcttctttt  ctccacgaa  caggatcaa  taaccccac  ggattaaac  14760
ccgacgcag  caaaatccc  ttccatcca  attatacaa  taaagacct  ctaggtgta  14820
ttatattac  attattcct  ataacccta  tactattct  cccagacct  ctaggagac  14880
cagacaatt  tacacccgc  aaccccctc  acaccccac  ccacatcaa  ccagaatga  14940
actttctct  tgcctacgc  attctacgc  ccattccca  caaactagg  ggggtcgta  15000
ccctaatct  atcaatcct  atcttagcc  tcctaccat  cctgcatac  tcaaaacaa  15060
gcagcttaa  attccgccc  atcacccaa  tcctttact  aatcctagt  gccaacctc  15120
tagtcttaa  atgaatcgg  ggccaacca  tagaacacc  atttatcat  attggtcaa  15180
tagcctcca  cagttattt  tcaattatc  tcattctca  accaatctc  ggaattgtt  15240
aagacaaaa  gttaaaatg  aattaatgt  ccgatagta  aaaaattac  ctggtcttg  15300
aaaccaaaa  tgaagagtc  gtcttctca  gacaatcaa  aagaaggaa  tacctcccc  15360
ccatcaaca  ccaaagctg  tattctact  aaactactt  ttgtcagta  ataaaatga  15420
atggacatt  aaacattta  gtatatcgt  cattaaatt  ttttcccca  gcatataag  15480
atgtaatat  tatctaatg  tttaggaca  acatttaaa  tcaactata  attcacaac  15540
acatgtcta  tctcaaata  attaagata  tgcttatta  acatatctg  gttattaga  15600
atgcaccat  aagtcataa  cctttctct  ccatatgac  atccctgtc  ccaattggt  15660
tctatttct  ccatcctcc  tgaaatcaa  aacccgccc  ctcgtcccc  tcttctcgc  15720
ccgggccca  tcgtcctgg  ggtgactat  ctgaaactt  accaggcat  tggttctta  15780
ttcagggcc  tcaattggt  catcgtcca  acgttcccc  taaataaga  atctcgatg  15840
taacgggtc  aatcagccc  tgatcaaca  aactgtggt  atatacatt  ggtattttt  15900
aattttcgg  tgccttcct  aacatagcc  tcaaggcat  aaggtcagc  caaagtcct  15960
tggaacctt  tagttaagg  tcatttatc  tcatagaca  agctcgaaa  actatttta  16020
tcatgtttg  aagacataa  tatttataa  tactgaaaa  tctgtcaac  aaccccccc  16080
ccccctaca  ctgaaactt  aatgccaaa  cccaaaaac  ttaaagcaa  aattaaata  16140
aacaaaaag  tacttaatt  ttaaaaggc  tctccattc  agtagacca  aaaatttta  16200
cttaaatct  agcattggt  aaatttccc  acacaaaat  tttcctcct  actaaaccc  16260
ctttacttg  ctaccctca  aaaattcca  atacaccaaa  16300



<210> 9426
<211> 2000
<212> DNA
<213> Rattus norvegicus
<308> X15468
<400> 9426

gcagcaccc  ggctcgggg  cgcgacggc  gcggggcgc  ccctccccc  tgccggggc  60
cggcgaagg  atgtggggc  ttgcgggag  aaggctttt  ggcatcttc  cggccccgg  120
gctggtggc  gtggtttgc  gcgcccaga  cgtaaacga  cccgggaac  tgtcctttg  180
gaaggagac  gtcgacaag  tgttgaaag  ctacgacat  cgcctgaga  cggacttcg  240
gggtccccc  gtctgcgtg  ggatgaaca  cgacatcgc  agcatcgac  tggtttctg  300
agtcaacat  gattatacc  taactatgt  tttccaaca  tattggaga  ataaaaggc  360
cgcctactc  gggatccct  tcaacctca  gcttgacaa  cgagtggct  accagctct  420
ggtgcctga  acatatttc  taaatgaca  aaagtcatt  gtgcacgga  tgacagtga  480
aaaccgcat  atccgcctc  accctgatg  aacagtgct  tacgggctc  ggatcacca  540
cacagcagc  tgcatgatg  acctcagaa  atacccact  gatgagcaa  actgcaccc  600
ggaaattga  agctatgga  acaccacgg  tgacattga  ttttactgg  gtggcgggg  660
caaggctgt  actggcgtg  aaaggatcg  gctcccaca  ttctccatt  tggagcacc  720
tctggtctc  aggaatgtt  tcttcgcca  aggtgccta  cctcgactc  cattgagtt  780
tcggttgaa  agaaacatt  ggtacttca  acttcagac  tatatgccc  caatcatga  840
cacaatcct  tcatgggtg  ccttctgga  caattatga  gcatctgct  ctcgagttg  900
cctagggat  accaccgtg  tcaccatga  aaccatcaa  actcacctt  gagagactc  960
acccaaaat  ccctacgtc  aagccatcg  catgtacct  atgggttgc  tcgtctttg  1020
attcctggc  cttctggag  atgcctttg  caactatat  ttctttgga  gaggtcccc  1080
acggcagaa  aagcttgcg  agaagacag  caaggccaa  aatgatcga  ccaagagtg  1140
aatcaaccg  gtggatgct  acgggaata  cctactagc  ccgatggat  ttcacaatg  1200
aatgaatga  gttgcaggc  gcgttggtg  caccaggaa  tcagcaata  cctttgaca  1260
ctcaggaat  cagtatagg  aacagagca  gcccaagga  gggcatggg  ggtacatgg  1320
agacagaag  atcccgcac  agaagacgc  cctacggag  aggtcttcg  agctcaaaa  1380
caaaatccc  gatctaacc  atgtgaatg  catagacag  tggtcccgg  tcgtgtttc  1440
attcacctt  tctctcttc  acttagttt  ctggctgta  tatgttaac  gagtgactg  1500
acttgattt  ttcaaagac  tcatttaac  ctgagtgaa  tattaccct  cctgtcaag  1560
ttttatacc  gtatacaca  acacacaca  aaacaaacg  acacacaaa  acacacata  1620
acaaacaca  acacacaca  acatacaca  acacacaca  ttgtatata  atgtgaact  1680
tctcagcat  tatataaaa  acacgtgta  atgagaatg  atgtgtata  gtttatgta  1740
actggtgag  gtgcctgtg  atgtaaaac  aatacgcat  cataccata  attttgcaa  1800
tatggacaa  ttaacacag  atgcatatt  aagaaagtc  tagcttttt  tttcttttt  1860
aattgaaag  gacaagtat  taaatatta  gcctcaaga  tgagggcga  aaacacagt  1920
atcccaaag  gtgtctttt  ttatcataa  tttttgctt  agaatcaaa  cggaattct  1980
agttaatct  tgggcactcc  2000



<210> 9427
<211> 473
<212> PRT
<213> Rattus norvegicus
<308> CAA33495
<400> 9427

Met Trp Gly Phe Ala Gly Gly Arg Leu Phe Gly Ile Phe Ser Ala Pro 
  1               5                  10                  15
Val Leu Val Ala Val Val Cys Cys Ala Gln Ser Val Asn Asp Pro Gly 
             20                  25                  30
Asn Met Ser Phe Val Lys Glu Thr Val Asp Lys Leu Leu Lys Gly Tyr 
         35                  40                  45
Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Cys Val Gly 
     50                  55                  60
Met Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
 65                  70                  75                  80
Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Tyr Trp Arg Asp Lys Arg 
                 85                  90                  95
Leu Ala Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
             100                105                110
Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
         115                120                125
Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
     130                135                140
Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
 145                150                155                160
Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                 165                170                175
Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
             180                185                190
Trp Arg Gly Gly Asp Lys Ala Val Thr Gly Val Glu Arg Ile Glu Leu 
         195                200                205
Pro Gln Phe Ser Ile Val Glu His Arg Leu Val Ser Arg Asn Val Val 
     210                215                220
Phe Ala Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
 225                230                235                240
Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu 
                 245                250                255
Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser 
             260                265                270
Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
         275                280                285
Ile Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys 
     290                295                300
Ala Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala 
 305                310                315                320
Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro 
                 325                330                335
Gln Arg Gln Lys Lys Leu Ala Glu Lys Thr Ala Lys Ala Lys Asn Asp 
             340                345                350
Arg Ser Lys Ser Glu Ile Asn Arg Val Asp Ala His Gly Asn Ile Leu 
         355                360                365
Leu Ala Pro Met Asp Val His Asn Glu Met Asn Glu Val Ala Gly Ser 
     370                375                380
Val Gly Asp Thr Arg Asn Ser Ala Ile Ser Phe Asp Asn Ser Gly Ile 
 385                390                395                400
Gln Tyr Arg Lys Gln Ser Met Pro Lys Glu Gly His Gly Arg Tyr Met 
                 405                410                415
Gly Asp Arg Ser Ile Pro His Lys Lys Thr His Leu Arg Arg Arg Ser 
             420                425                430
Ser Gln Leu Lys Ile Lys Ile Pro Asp Leu Thr Asp Val Asn Ala Ile 
         435                440                445
Asp Arg Trp Ser Arg Ile Val Phe Pro Phe Thr Phe Ser Leu Phe Asn 
     450                455                460
Leu Val Tyr Trp Leu Tyr Tyr Val Asn 
 465                470



<210> 9428
<211> 1720
<212> DNA
<213> Homo sapiens
<308> NM_000814
<400> 9428

ctcctcccc  ccccctccg  cctcctccg  tccgggcca  cgcggcggc  gcggcggcg  60
cagcagcag  agcagcccc  gctgcgggt  gcgacggcg  cggggcgcc  cctcccccg  120
gccggggcg  ggcggaggg  tgtggggcc  tgcgggagg  aggcttttc  gcatcttct  180
ggccccggt  ctggtggct  tggtgtgct  cgcccagag  gtgaacgat  ccgggaaca  240
gtcctttgt  aaggagacg  tggacaagc  gttgaaagg  tacgacatt  gcctaagac  300
cgacttcgg  ggtcccccg  tctgcgtgg  gatgaacat  gacatcgcc  gcatcgaca  360
ggtttccga  gtcaacatg  attatacct  aaccatgta  tttcaacaa  attggagag  420
taaaaggct  gcctattct  ggatccctc  caacctcac  cttgacaat  gagtggctg  480
ccagctatg  gtgcccgac  catatttct  aaatgacaa  aagtcattt  tgcatggag  540
gacagtgaa  aaccgcatg  tccgtcttc  ccctgatgg  acagtgctg  atgggctca  600
aatcaccac  acagcagca  gcatgatgg  cctcaggag  taccccctg  acgagcaga  660
ctgcactct  gaaattgaa  gctatggct  caccacgga  gacattgag  tttactggc  720
aggcgggga  aaggctgtt  ccggagtgg  aaggattga  ctcccgcag  tctccatcg  780
ggagcaccg  ctggtctcg  ggaatgttg  cttcgccac  ggtgcctat  ctcgactgt  840
actgagctt  cggttgaag  ggaacattg  atacttcat  cttcagact  atatgccct  900
tatactgat  acgattctg  cgtgggtgt  cttctggat  aattatgat  catctgctg  960
tagagttgc  ctcgggatc  caactgtgc  gacaatgac  accatcaac  cccaccttc  1020
ggagacctt  cccaaaatc  cctatgtca  agccattga  atgtacctt  tgggctgct  1080
cgtctttgt  ttcctggcc  ttctggagt  tgcctttgt  aactacatt  tctttggaa  1140
aggccctca  aggcagaag  agcttgcag  aaagacagc  aaggcaaag  atgaccgtt  1200
aaagagcga  agcaaccgg  tggatgctc  tggaaatat  ctgttgaca  cgctggaag  1260
tcacaatga  atgaatgag  tctcaggcg  cattggcga  accaggaat  cagcaatat  1320
ctttgacaa  tcaggaatc  agtacagga  acagagcat  cctcgagaa  ggcatgggc  1380
attcctggg  gacagaagc  tcccgcaca  gaagaccca  ctacggagg  ggtcttcac  1440
gctcaaaat  aaaatacct  atctaaccg  tgtgaatgc  atagacaga  ggtccagga  1500
cgtgtttcc  ttcactttt  ctcttttca  cttagttta  tggctgtac  atgttaact  1560
agtgactgt  cttgatttt  caaagactt  atttaacac  gagtgaaat  ttactctgc  1620
tgtcaagtt  ttatacctg  acacacaca  acacacaag  agacacaca  atatataca  1680
acgcaattg  atatatatg  gaacttctc  gcatatatat  1720



<210> 9429
<211> 473
<212> PRT
<213> Homo sapiens
<308> P28472
<400> 9429

Met Trp Gly Leu Ala Gly Gly Arg Leu Phe Gly Ile Phe Ser Ala Pro 
  1               5                  10                  15
Val Leu Val Ala Val Val Cys Cys Ala Gln Ser Val Asn Asp Pro Gly 
             20                  25                  30
Asn Met Ser Phe Val Lys Glu Thr Val Asp Lys Leu Leu Lys Gly Tyr 
         35                  40                  45
Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Cys Val Gly 
     50                  55                  60
Met Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
 65                  70                  75                  80
Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Tyr Trp Arg Asp Lys Arg 
                 85                  90                  95
Leu Ala Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
             100                105                110
Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
         115                120                125
Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
     130                135                140
Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
 145                150                155                160
Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                 165                170                175
Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
             180                185                190
Trp Arg Gly Gly Asp Lys Ala Val Thr Gly Val Glu Arg Ile Glu Leu 
         195                200                205
Pro Gln Phe Ser Ile Val Glu His Arg Leu Val Ser Arg Asn Val Val 
     210                215                220
Phe Ala Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
 225                230                235                240
Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu 
                 245                250                255
Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser 
             260                265                270
Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
         275                280                285
Ile Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys 
     290                295                300
Ala Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala 
 305                310                315                320
Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro 
                 325                330                335
Gln Arg Gln Lys Lys Leu Ala Glu Lys Thr Ala Lys Ala Lys Asn Asp 
             340                345                350
Arg Ser Lys Ser Glu Ser Asn Arg Val Asp Ala His Gly Asn Ile Leu 
         355                360                365
Leu Thr Ser Leu Glu Val His Asn Glu Met Asn Glu Val Ser Gly Gly 
     370                375                380
Ile Gly Asp Thr Arg Asn Ser Ala Ile Ser Phe Asp Asn Ser Gly Ile 
 385                390                395                400
Gln Tyr Arg Lys Gln Ser Met Pro Arg Glu Gly His Gly Arg Phe Leu 
                 405                410                415
Gly Asp Arg Ser Leu Pro His Lys Lys Thr His Leu Arg Arg Arg Ser 
             420                425                430
Ser Gln Leu Lys Ile Lys Ile Pro Asp Leu Thr Asp Val Asn Ala Ile 
         435                440                445
Asp Arg Trp Ser Arg Ile Val Phe Pro Phe Thr Phe Ser Leu Phe Asn 
     450                455                460
Leu Val Tyr Trp Leu Tyr Tyr Val Asn 
 465                470



<210> 9430
<211> 435
<212> DNA
<213> Rattus norvegicus
<308> X15512
<400> 9430

ggatcatag  ggtgggagg  ggtgggtac  agtgatgcc  cctatccgc  cgcgtctgc  60
tccagggtg  ccctccagc  aggatgagg  tcttcatcg  acttcctgt  ctgatcgtg  120
tcgtagcca  ggctttgga  ggcccagcc  ctgcccagg  ggcccctga  ttttccagc  180
caatggaga  cttaccgga  aaactaaaa  agtttggga  cactttgga  gataaggcc  240
gggcagcca  tgagcatat  aaacagaag  aaattatga  caagactcg  aactggttt  300
cagagacgc  caacaaaat  aaggagaaa  taaaaacca  atttgcctg  gtgcctggc  360
agccacctc  cagcagcaa  gagggccac  tgacgggcc  ggtccctct  caaatacca  420
taaaaactt  tagag  435



<210> 9431
<211> 88
<212> PRT
<213> Rattus norvegicus
<308> P19939
<400> 9431

Met Arg Leu Phe Ile Ala Leu Pro Val Leu Ile Val Val Val Ala Met 
  1               5                  10                  15
Ala Leu Glu Gly Pro Ala Pro Ala Gln Ala Ala Pro Asp Phe Ser Ser 
             20                  25                  30
Ala Met Glu Ser Leu Pro Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu 
         35                  40                  45
Glu Asp Lys Ala Arg Ala Ala Ile Glu His Ile Lys Gln Lys Glu Ile 
     50                  55                  60
Met Ile Lys Thr Arg Asn Trp Phe Ser Glu Thr Leu Asn Lys Met Lys 
 65                  70                  75                  80
Glu Lys Leu Lys Thr Thr Phe Ala 
                 85



<210> 9432
<211> 417
<212> DNA
<213> Homo sapiens
<308> NM_001645
<400> 9432

acctcccaa  caagccctc  agcaaggat  caggagtgc  cctcgggcc  cgccatgag  60
ctcttcctg  cgctcccgg  cctggtggt  gttctgtcg  tcgtcttgg  aggcccagc  120
ccagcccag  ggaccccag  cgtctccag  gccttggat  agctgaagg  gtttggaaa  180
acactggag  acaaggctc  ggaactcat  agccgcatc  aacagagtg  actttctgc  240
aagatgcgg  agtggtttt  agagacatt  cagaaagtg  aggagaaac  caagattga  300
tcatgagga  ctgaagggt  acatccagg  ggggcctct  aaatttccc  caccccagc  360
cctgtgctg  ggactcccg  catgtggcc  caggtgcca  caataaaaa  cctaccg  417



<210> 9433
<211> 83
<212> PRT
<213> Homo sapiens
<308> P02654
<400> 9433

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
  1               5                  10                  15
Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
             20                  25                  30
Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
         35                  40                  45
Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 
     50                  55                  60
Arg Glu Trp Phe Ser Glu Thr Phe Gln Lys Val Lys Glu Lys Leu Lys 
 65                  70                  75                  80
Ile Asp Ser 
                 85



<210> 9435
<211> 633
<212> PRT
<213> Rattus norvegicus
<308> CAA33735
<400> 9435

Met Ser Ala Arg Gly Pro Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr 
  1               5                  10                  15
Ser Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn 
             20                  25                  30
Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr 
         35                  40                  45
Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro 
     50                  55                  60
Thr Asn Thr Ile Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Glu 
 65                  70                  75                  80
Asp Ala Thr Val Gln Ser Asp Met Lys His Trp Pro Phe Arg Val Val 
                 85                  90                  95
Ser Glu Gly Gly Lys Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Met 
             100                105                110
Lys Thr Phe Phe Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met 
         115                120                125
Lys Glu Ile Ala Glu Ala Tyr Leu Gly Gly Lys Val Gln Ser Ala Val 
     130                135                140
Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys 
 145                150                155                160
Asp Ala Gly Thr Ile Thr Gly Leu Asn Val Leu Arg Ile Ile Asn Glu 
                 165                170                175
Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Gly Cys Ala 
             180                185                190
Gly Gly Glu Lys Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe 
         195                200                205
Asp Val Ser Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser 
     210                215                220
Thr Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met 
 225                230                235                240
Val Ser His Leu Ala Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile 
                 245                250                255
Gly Pro Asn Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg 
             260                265                270
Ala Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp 
         275                280                285
Ser Leu Tyr Glu Gly Val Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg 
     290                295                300
Phe Glu Glu Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Glu Pro Val 
 305                310                315                320
Glu Lys Ala Leu Arg Asp Ala Lys Leu Asp Lys Gly Gln Ile Gln Glu 
                 325                330                335
Ile Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu 
             340                345                350
Leu Gln Asp Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro 
         355                360                365
Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ile 
     370                375                380
Gly Asp Lys Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr 
 385                390                395                400
Pro Leu Ser Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Pro Leu 
                 405                410                415
Ile Lys Arg Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr 
             420                425                430
Thr Tyr Ser Asp Asn Gln Ser Ser Val Leu Val Gln Val Tyr Glu Gly 
         435                440                445
Glu Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Asp Leu 
     450                455                460
Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr 
 465                470                475                480
Phe Asp Ile Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Ala Asp Lys 
                 485                490                495
Ser Thr Gly Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg 
             500                505                510
Leu Ser Lys Asp Asp Ile Asp Arg Met Val Gln Glu Ala Asp Gly Tyr 
         515                520                525
Lys Ser Glu Asp Glu Ala Asn Arg Asp Arg Val Ala Ala Lys Asn Ala 
     530                535                540
Val Glu Ser Tyr Thr Tyr Asn Ile Lys Gln Thr Val Glu Asp Glu Lys 
 545                550                555                560
Leu Arg Gly Lys Ile Ser Glu Gln Asp Lys Asn Lys Ile Leu Asp Lys 
                 565                570                575
Cys Gln Glu Val Ile Asn Trp Leu Asp Arg Asn Gln Met Ala Glu Lys 
             580                585                590
Asp Glu Tyr Glu His Lys Gln Lys Glu Leu Glu Arg Val Cys Asn Pro 
         595                600                605
Ile Ile Ser Lys Leu Tyr Gln Gly Gly Pro Gly Gly Gly Gly Ser Ser 
     610                615                620
Gly Gly Pro Thr Ile Glu Glu Val Asp 
 625                630



<210> 9436
<211> 4858
<212> DNA
<213> Homo sapiens
<308> U56725
<400> 9436

ggaattctt  ttttttttt  tttttttga  acagggtct  gctctgtca  ccaggctaa  3780
gtgtagtgc  gcgatctca  ctcattaca  cctctgcct  ccaggttca  gggatcctc  3840
cacctcagc  tcccaagca  ttgggacca  aggcatgtg  caccatatc  ggctaattt  3900
tgctttttt  atagagaca  ggtttcacc  tgttgcaca  gtcggtctt  aactcctga  3960
ctcaagtga  ctacctgct  tggcctccc  aagtgctgg  attacacat  tgaaccacc  4020
tacccggcc  caaaaatgc  ttcttaagc  taactacgt  atgctagtt  tagtttaga  4080
tcctggatg  taacttaaa  tagtcccat  ggaacccag  gtggtggct  acgcctgta  4140
tcccagcct  aggcaggtg  atcatctga  gtcaggagt  cgagaccag  tgggccaac  4200
tggtgaaac  ctgtctcta  taaaaacac  aaaaaatta  ctgggcata  tggcaggca  4260
ccgtaattt  agcttctcg  gacgctgag  cagaagaat  gcttgaacc  aggaggcag  4320
ggttgcagt  agcccagat  gtgccattg  actccagcc  gggcaacaa  agcaaaact  4380
tgtctcaaa  aaatcaatt  atttaggct  ggcgcagtg  ctcatgcct  taaatccca  4440
cactttgag  ggctgaagc  ggtggatca  gaggtcaag  gatcgagac  atcctggct  4500
acacggtga  accccattt  tactaaaaa  acaaaaaaa  aaccccaaa  aacaaaaaa  4560
caaaaacaa  caaacaaac  aaaaaaaca  aacaactag  caggcgtag  ggcaggcgc  4620
tgtaatccc  gctagtcgg  aggctgagg  aggaggaga  tggagtgaa  ccaggaggc  4680
gagcttgca  tgagctgag  tcgcgccac  gcactccag  ctgggcaac  gagcgagac  4740
ccatctcag  aaaaaaaaa  ttaattaat  aaaaaaaca  taagataaa  aacacttct  4800
ccatttcag  aaaaggatg  agccagttt  tcaatgaat  aaaacaaga  actgttga  4858



<210> 9437
<211> 639
<212> PRT
<213> Homo sapiens
<308> P54652
<400> 9437

Met Ser Ala Arg Gly Pro Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr 
  1               5                  10                  15
Ser Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn 
             20                  25                  30
Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr 
         35                  40                  45
Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro 
     50                  55                  60
Thr Asn Thr Ile Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Glu 
 65                  70                  75                  80
Asp Ala Thr Val Gln Ser Asp Met Lys His Trp Pro Phe Arg Val Val 
                 85                  90                  95
Ser Glu Gly Gly Lys Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr 
             100                105                110
Lys Thr Phe Phe Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met 
         115                120                125
Lys Glu Ile Ala Glu Ala Tyr Leu Gly Gly Lys Val His Ser Ala Val 
     130                135                140
Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys 
 145                150                155                160
Asp Ala Gly Thr Ile Thr Gly Leu Asn Val Leu Arg Ile Ile Asn Glu 
                 165                170                175
Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Gly Cys Ala 
             180                185                190
Gly Gly Glu Lys Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe 
         195                200                205
Asp Val Ser Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser 
     210                215                220
Thr Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met 
 225                230                235                240
Val Ser His Leu Ala Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile 
                 245                250                255
Gly Pro Asn Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg 
             260                265                270
Ala Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp 
         275                280                285
Ser Leu Tyr Glu Gly Val Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg 
     290                295                300
Phe Glu Glu Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Glu Pro Val 
 305                310                315                320
Glu Lys Ala Leu Arg Asp Ala Lys Leu Asp Lys Gly Gln Ile Gln Glu 
                 325                330                335
Ile Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu 
             340                345                350
Leu Gln Asp Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro 
         355                360                365
Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ile 
     370                375                380
Gly Asp Lys Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr 
 385                390                395                400
Pro Leu Ser Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Pro Leu 
                 405                410                415
Ile Lys Arg Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr 
             420                425                430
Thr Tyr Ser Asp Asn Gln Ser Ser Val Leu Val Gln Val Tyr Glu Gly 
         435                440                445
Glu Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Asp Leu 
     450                455                460
Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr 
 465                470                475                480
Phe Asp Ile Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Ala Asp Lys 
                 485                490                495
Ser Thr Gly Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg 
             500                505                510
Leu Ser Lys Asp Asp Ile Asp Arg Met Val Gln Glu Ala Glu Arg Tyr 
         515                520                525
Lys Ser Glu Asp Glu Ala Asn Arg Asp Arg Val Ala Ala Lys Asn Ala 
     530                535                540
Leu Glu Ser Tyr Thr Tyr Asn Ile Lys Gln Thr Val Glu Asp Glu Lys 
 545                550                555                560
Leu Arg Gly Lys Ile Ser Glu Gln Asp Lys Asn Lys Ile Leu Asp Lys 
                 565                570                575
Cys Gln Glu Val Ile Asn Trp Leu Asp Arg Asn Gln Met Ala Glu Lys 
             580                585                590
Asp Glu Tyr Glu His Lys Gln Lys Glu Leu Glu Arg Val Cys Asn Pro 
         595                600                605
Ile Ile Ser Lys Leu Tyr Gln Gly Gly Pro Gly Gly Gly Ser Gly Gly 
     610                615                620
Gly Gly Ser Gly Ala Ser Gly Gly Pro Thr Ile Glu Glu Val Asp 
 625                630                635



<210> 9438
<211> 3507
<212> DNA
<213> Rattus norvegicus
<308> X16002
<400> 9438

ctaagacta  agacttatt  gcattttat  taaattaga  ggacttggc  ttggacaat  60
tccatacaa  aaaaaaaaa  atttcattt  ctaggcaca  cttctgact  tcagattct  120
gctgccttt  agtcttgta  cgtcatcat  agaccgcat  ccagacaga  ttccagatt  180
gaacaccta  cccccaaaa  gtaggtgtt  gggagacca  atcacttca  gacttatgt  240
tgaggagca  taggctgtt  tctagacta  gcaagctct  gaaagcaat  ctgagtctc  300
gagaagagg  agcatgggg  gtgctgatt  aaaaacaga  aatgcaaag  tggactgaa  360
atatcccaa  tcttctaag  aatctgctt  aggcttcca  acttacctt  atttggtaa  420
aaaataagc  gccctattt  tctttcttc  tctcttaca  ctggaacca  ccatttccc  480
aaactacca  catggaggt  gcaatggtg  gtgccgaga  ctcagggtg  aacagccac  540
tgccttatg  ttatgctgc  caggccagg  ctcgagaga  ggagagact  gctcactcc  600
gggcagctg  agctgctgc  gttgcagct  ccacggctg  ggtggaagg  actggaggt  660
ctggtggag  cccccacca  catcatcag  cacgtgggg  ctactcctc  catgatcct  720
aaggaagcc  aggtagtcg  gaggaggag  ccacacgaa  tgagaagaa  aagaaactc  780
accacaggc  gagcagttt  cctcattgc  cagacctga  gcccagtgg  tctgaagag  840
agatcctta  ggagctgag  gaggaggag  aagacgagg  ggaggaaga  gaggaggaa  900
aggagggaa  gttttacta  agtgaagag  accatgggg  tgggtgttc  tacactgac  960
tactgccac  ggacgatgg  ggtggcggc  gctacagtt  agtccgcta  agtgactgt  1020
gtgaacgcg  ggtaataaa  gtgtctggt  tacgcttcg  aacccaaat  aaaactttg  1080
ctcagtttc  agaaactct  ttgggagac  ctgagaaga  gactcagta  ttcgaccct  1140
tgcgcaatg  gtatttttt  gataggaac  gtcccagct  tgatgccat  ttgtattat  1200
accagtcag  aggccgcct  aagaggcca  tcaatgtcc  ctttgatat  ttcactgag  1260
aggtgaagt  ctatcagtt  ggagaggaa  ccctgctca  gttccgtga  gatgagggc  1320
ttgtgagag  agaggagga  agggctctg  cagaaaatg  atttaaaaa  cagatttgg  1380
ttctctttg  atatcccga  agttccagc  ctgccaggg  catagccat  gtatctgtc  1440
tggtcatct  aatctctat  gtcatattt  gcctggaaa  cttgcctga  ttcagggat  1500
atagggacc  catcatggc  ctcagcgca  gtggacaca  cagattatt  aatgacacc  1560
cggcacccc  cctggagaa  tcagggcac  caatattca  tgacccttt  ttcattgtg  1620
agacagtat  tatcgtgtg  ttttccttt  agtttgtgg  tcgatgctt  gcttgtccc  1680
gtcaagcac  cttcttcaa  aacatcatg  acatcattg  tatcgtctc  attttgcct  1740
acttcatca  tctgggcac  gatctggcc  agcagcagg  gggtggcaa  ggccagcag  1800
agcaggcta  gtcctttgc  atcctcagg  tcatccgtc  ggtccgagt  ttccggatc  1860
tcaagctct  cagacactc  aagggcctg  agatcctgg  ccacaccct  agagccagc  1920
tgcgtgaac  gggccttct  atctttttc  tcttcatcg  ggtcatcct  ttttccagc  1980
ctgtgtatt  tgcagaggc  gatgaacct  ccacccatt  ccaaagcat  ccagatgcg  2040
tttggtggg  tgtggtaac  atgacaact  tgggctacg  ggacatgaa  cccatcaca  2100
tgggaggaa  gattgtggg  tccctgtgt  ccattgcgg  tgtcttaac  attgctttg  2160
ccgtgccgg  gattgtgtc  aactttaac  atttctacc  cagagagac  gaaaacgaa  2220
aacagaccc  gctgaccca  aacgcagtc  gttgcccat  cctaccttc  aatttgctc  2280
agaaatttc  gagctctac  tcttcttcc  tgggggaca  gtcagagta  ctagagatg  2340
aagaagggg  caaggagtc  ttatgtgga  aggaagaga  gtgtcaggg  aagggggat  2400
acagcgaga  agataaaaa  aactgttct  atgcaaagg  tgtggagac  gatgtgtga  2460
tctctttcc  ccacctgcc  gtgccgccc  cccagctcc  atatattca  acataaaga  2520
tgcagttat  aaaatgaga  atactgcat  cagtaatac  ctgcttaat  gcgatacat  2580
gcataattg  ggcgaaacg  gtattgcat  tcaaataag  gatgcatct  ggagaagag  2640
gaggcatta  aaacagcag  tctatcttt  tatttttta  tagaatgca  gaattttgc  2700
cataatggg  aaatgttat  gtaaaggtg  tcccgagga  agtgagtgt  tgtgagaga  2760
tgagagagt  tgtggccat  ggagtgtaa  taaattgtc  acattgttg  gaattgtgc  2820
gtgatggga  aagttggca  tctgaagta  ttactatgt  agaactaat  aacttgagc  2880
gtcttttac  agtgtttta  taacatctc  tatgtcttt  gattctgta  ttgttttct  2940
gaaattgta  gaattactg  gtagaaaaa  gagaaagta  attatttaa  agatatagg  3000
cacaattta  tcttggatt  aattaaagt  tatttttaa  tggaaatta  cttttgaaa  3060
ggctctacc  ctttttaca  attgttata  tttcttatt  attttggga  atatactag  3120
aaatgccta  tgttctgga  gaaatgtaa  aagttttgt  cacaggtct  aagactgga  3180
ttttttctt  gcactactt  tatgctgaa  cccgagaga  acttatact  tgatgttta  3240
taacgcacc  atcagttca  tgacaatca  tggaagaat  gtttcttcg  ctcatttat  3300
gttcttttc  ttttgtgag  ctaatgagc  cacagataa  agcacacga  tcctgcttt  3360
aaatctgac  accgatcta  aagggacta  gaggtaacg  tcagcagcc  aatctttca  3420
aattggttt  ttacaatga  gcttcagaa  catactatt  tcatactct  ctgcctttt  3480
agtccagat  atttaacca  agttatt  3507



<210> 9439
<211> 655
<212> PRT
<213> Rattus norvegicus
<308> CAA34133
<400> 9439

Met Glu Val Ala Met Val Ser Ala Glu Ser Ser Gly Cys Asn Ser His 
  1               5                  10                  15
Met Pro Tyr Gly Tyr Ala Ala Gln Ala Arg Ala Arg Glu Arg Glu Arg 
             20                  25                  30
Leu Ala His Ser Arg Ala Ala Ala Ala Ala Ala Val Ala Ala Ala Thr 
         35                  40                  45
Ala Ala Val Glu Gly Thr Gly Gly Ser Gly Gly Gly Pro His His His 
     50                  55                  60
His Gln Thr Arg Gly Ala Tyr Ser Ser His Asp Pro Gln Gly Ser Arg 
 65                  70                  75                  80
Gly Ser Arg Glu Glu Glu Ala Thr Arg Thr Glu Lys Lys Lys Lys Leu 
                 85                  90                  95
His His Arg Gln Ser Ser Phe Pro His Cys Ser Asp Leu Met Pro Ser 
             100                105                110
Gly Ser Glu Glu Lys Ile Leu Arg Glu Leu Ser Glu Glu Glu Glu Asp 
         115                120                125
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Arg Phe Tyr Tyr Ser 
     130                135                140
Glu Glu Asp His Gly Asp Gly Cys Ser Tyr Thr Asp Leu Leu Pro Gln 
 145                150                155                160
Asp Asp Gly Gly Gly Gly Gly Tyr Ser Ser Val Arg Tyr Ser Asp Cys 
                 165                170                175
Cys Glu Arg Val Val Ile Asn Val Ser Gly Leu Arg Phe Glu Thr Gln 
             180                185                190
Met Lys Thr Leu Ala Gln Phe Pro Glu Thr Leu Leu Gly Asp Pro Glu 
         195                200                205
Lys Arg Thr Gln Tyr Phe Asp Pro Leu Arg Asn Glu Tyr Phe Phe Asp 
     210                215                220
Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr Gln Ser Gly 
 225                230                235                240
Gly Arg Leu Lys Arg Pro Val Asn Val Pro Phe Asp Ile Phe Thr Glu 
                 245                250                255
Glu Val Lys Phe Tyr Gln Leu Gly Glu Glu Ala Leu Leu Lys Phe Arg 
             260                265                270
Glu Asp Glu Gly Phe Val Arg Glu Glu Glu Asp Arg Ala Leu Pro Glu 
         275                280                285
Asn Glu Phe Lys Lys Gln Ile Trp Leu Leu Phe Glu Tyr Pro Glu Ser 
     290                295                300
Ser Ser Pro Ala Arg Gly Ile Ala Ile Val Ser Val Leu Val Ile Leu 
 305                310                315                320
Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Phe Arg Asp 
                 325                330                335
Asp Arg Asp Leu Ile Met Ala Leu Ser Ala Gly Gly His Ser Arg Leu 
             340                345                350
Leu Asn Asp Thr Ser Ala Pro His Leu Glu Asn Ser Gly His Thr Ile 
         355                360                365
Phe Asn Asp Pro Phe Phe Ile Val Glu Thr Val Cys Ile Val Trp Phe 
     370                375                380
Ser Phe Glu Phe Val Val Arg Cys Phe Ala Cys Pro Ser Gln Ala Leu 
 385                390                395                400
Phe Phe Lys Asn Ile Met Asn Ile Ile Asp Ile Val Ser Ile Leu Pro 
                 405                410                415
Tyr Phe Ile Thr Leu Gly Thr Asp Leu Ala Gln Gln Gln Gly Gly Gly 
             420                425                430
Asn Gly Gln Gln Gln Gln Ala Met Ser Phe Ala Ile Leu Arg Ile Ile 
         435                440                445
Arg Leu Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys 
     450                455                460
Gly Leu Gln Ile Leu Gly His Thr Leu Arg Ala Ser Met Arg Glu Leu 
 465                470                475                480
Gly Leu Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe Ser Ser 
                 485                490                495
Ala Val Tyr Phe Ala Glu Ala Asp Glu Pro Thr Thr His Phe Gln Ser 
             500                505                510
Ile Pro Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly 
         515                520                525
Tyr Gly Asp Met Lys Pro Ile Thr Val Gly Gly Lys Ile Val Gly Ser 
     530                535                540
Leu Cys Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val 
 545                550                555                560
Ile Val Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Glu Asn Glu 
                 565                570                575
Glu Gln Thr Gln Leu Thr Gln Asn Ala Val Ser Cys Pro Tyr Leu Pro 
             580                585                590
Ser Asn Leu Leu Lys Lys Phe Arg Ser Ser Thr Ser Ser Ser Leu Gly 
         595                600                605
Asp Lys Ser Glu Tyr Leu Glu Met Glu Glu Gly Val Lys Glu Ser Leu 
     610                615                620
Cys Gly Lys Glu Glu Lys Cys Gln Gly Lys Gly Asp Asp Ser Glu Thr 
 625                630                635                640
Asp Lys Asn Asn Cys Ser Asn Ala Lys Ala Val Glu Thr Asp Val 
                 645                650                655



<210> 9440
<211> 3388
<212> DNA
<213> Homo sapiens
<308> M55514
<400> 9440

ttaacaagt  atcgctgct  tctaggatt  tgtttcttt  cgggggaac  ttgacttcc  60
ttcccaggc  atccctcct  tgctgaact  cagaggaac  aggagtctt  gggtcttct  120
tggggcagc  ccaaccccc  cccccaggc  ccagccgcg  ggactctgt  cacccctcg  180
gccaggcaa  agaacttgt  ccgtggata  ttggagcct  cacctgcca  acccgagtg  240
ttcctttta  caccccccg  cccccaccc  ggatcattc  tcccctcct  cagctgttg  300
agcttgagg  ggaaaaaca  gccagccgg  ggattttct  tatttttat  tttcgcccc  360
ccggggaag  gtgaagtgc  tcttctgca  gattttggc  gaagaatgc  ctgcatttc  420
ttgatttct  tggagacct  agagctggt  ttgcttctg  tgacacctc  tctagcacc  480
tctctacct  ccagggtct  tgcctctat  tgtggtttg  cattgtacc  gggtacagg  540
agcctttga  gaacttaaa  ggagagcct  gagaatcat  ctgatagac  ttgagtaga  600
atggctgga  atacttcaa  ccacatctt  acatggttc  agccatcac  agaaggcaa  660
tgctaacag  aaaggctta  ttgcatttt  tttacattt  atggactga  cattggcca  720
tttccatgg  agaaaaata  atttcattt  ctaggcaca  cttctggct  tcagacact  780
gctgccttt  aatcttgca  caacatcac  aaccacatc  cagacatat  tccaaattt  840
aacatctac  cccaaaaca  aggtgtctg  gagactcca  cattttcgg  cttcttagt  900
ttgagagtg  caggctatt  atctcgacc  gccaagctc  ggagagcaa  gttgaatcc  960
tgagaagag  gaggcatgg  gcgtgctga  ttaaaaaca  aaaatgcaa  gttggagct  1020
aaaatatcc  tagtcttcc  agcaatctg  ttaagggtt  caaacttac  ttaatttgg  1080
gagaaaaga  gctgcccta  ttttctttc  tcttcttct  caactggaa  cagccattt  1140
cgaaaacca  caccatgga  gttgcaatg  tgagtgcgg  gagctcagg  tgcaacagt  1200
acatgcctt  tggttatgc  gcccaggcc  gggcccggg  gcgggagag  cttgctcac  1260
ccaggcgag  tgcagcacg  gctgttgca  cggccacag  tgctgtcga  ggtagcggg  1320
gttctggtg  gggctccca  caccaccac  agtcacgcg  ggcctgtac  tcccatgac  1380
ctcagagca  ccggggtag  cgggaggag  aggcgacac  gtctgagaa  aagaaagcc  1440
actaccggc  gagcagctt  cctcattgc  ctgacctga  gcccagtgg  tctgaggag  1500
agatcctga  ggagctgag  gaggaggag  aagatgagg  ggaggagga  gaggaggaa  1560
aggagggaa  gttttacta  agtgaagat  accatggtg  tgagtgttc  tacacggat  1620
tgctgcctc  ggatgaggg  ggtggcggc  acagttcag  ccgctacag  gactgttgt  1680
aacgtgtgg  gataaatgt  tcaggccta  gctttgaga  ccaaatgaa  actctggcc  1740
agtttccag  gactttgtt  ggagaccct  aaaagagga  tcagtactt  gaccctttg  1800
gcaatgagt  tttttttga  aggaaccgc  ccagctttg  tgccatctt  tattattat  1860
aatcaggag  ccgcctgaa  aggccagtc  atgtcccct  tgatatctt  actgaggag  1920
tgaagttct  tcagttggg  gaggaggcc  tgttgaagt  tcgggagga  gagggcttt  1980
tgagagaag  ggaagacag  gccctcccc  agaatgaat  taaaaagca  atttggctc  2040
tctttgaat  tccagagag  tccgatcct  caaggggca  agccattgt  tccgtcctg  2100
tcatcttaa  ctccattgt  atcttttgc  tggaaacct  gcctgagtt  agggacgac  2160
gggatctcg  catggcact  agtgctggc  ggcatggtg  gttgttgaa  gatacttca  2220
caccccatc  ggagaactc  gggcacaca  tattcaatg  ccccttctt  atcgtggaa  2280
cagtctgta  tgtatggtt  tcctttgag  ttgtggttc  ctgctttgc  tgtcccagc  2340
aagcactct  cttcaaaaa  atcatgaac  tcattgaca  tgtctccat  ttgccttac  2400
tcatcacac  gggcactga  ctggcccag  aacaggggg  tggcaatgg  cagcagcag  2460
aggccatgt  ctttgccat  ctcagaatc  ttcgtctgg  ccgagtatt  cggatcttc  2520
aactctcca  gcactccaa  ggcctgcag  tcctgggcc  caccctcag  gccagcatg  2580
gggaactgg  ccttctgat  ttcttcctc  tcattgggg  catcctctt  tctagtgct  2640
tgtattttg  agaggcgga  gaacctact  cccatttcc  aagcatccc  gatgcattt  2700
ggtgggctg  ggtgaccat  acaactgtg  gctatgggg  catgaagcc  atcactgta  2760
ggggcaaga  tgtcggggt  ctgtgtgcc  ttgcgggtg  cttaaccat  gctttgcca  2820
tgccagtga  tgtctctaa  tttaactat  tctaccaca  agagactga  aatgaggaa  2880
agacacagc  aacgcagaa  gcagtcagt  gtccatacc  cccctctaa  ttgctcaag  2940
aatttcgga  ctctacttc  tcttccctg  gggacaagt  agagtatct  gagatggaa  3000
aaggagtta  ggaatctct  tgtgccaag  aggagaagt  tcaggccaa  ggggatgac  3060
gtgagacag  taaaaacaa  tgttctaat  caaaggctg  ggagactga  gtgtgaatc  3120
tttttttcc  cctgccact  ctcccccct  agccatctt  caaatatat  tatgcatag  3180
gagtgcagt  atgaaaatg  aatatgcaa  tgatccaat  cataccagt  gtacactat  3240
taatggtta  acatggcat  attgttact  aacttgtat  acatatcaa  taaatgata  3300
atcttggag  agagggagg  ataggagca  tctatcttt  tatttttat  agaatgcaa  3360
aattttcca  attaacctg  aaaagatg  3388



<210> 9441
<211> 653
<212> PRT
<213> Homo sapiens
<308> P22459
<400> 9441

Met Glu Val Ala Met Val Ser Ala Glu Ser Ser Gly Cys Asn Ser His 
  1               5                  10                  15
Met Pro Tyr Gly Tyr Ala Ala Gln Ala Arg Ala Arg Glu Arg Glu Arg 
             20                  25                  30
Leu Ala His Ser Arg Arg Ala Ala Ala Arg Ala Val Ala Ala Ala Thr 
         35                  40                  45
Ala Ala Val Glu Gly Ser Gly Gly Ser Gly Gly Gly Ser His His His 
     50                  55                  60
His Gln Ser Arg Gly Ala Cys Thr Ser His Asp Pro Gln Ser Ser Arg 
 65                  70                  75                  80
Gly Ser Arg Glu Glu Glu Ala Thr Arg Ser Glu Lys Lys Lys Ala His 
                 85                  90                  95
Tyr Arg Gln Ser Ser Phe Pro His Cys Ser Asp Leu Met Pro Ser Gly 
             100                105                110
Ser Glu Glu Lys Ile Leu Arg Glu Leu Ser Glu Glu Glu Glu Asp Glu 
         115                120                125
Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Arg Phe Tyr Tyr Ser Glu 
     130                135                140
Asp Asp His Gly Asp Glu Cys Ser Tyr Thr Asp Leu Leu Pro Gln Asp 
 145                150                155                160
Glu Gly Gly Gly Gly Tyr Ser Ser Val Arg Tyr Ser Asp Cys Cys Glu 
                 165                170                175
Arg Val Val Ile Asn Val Ser Gly Leu Arg Phe Glu Thr Gln Met Lys 
             180                185                190
Thr Leu Ala Gln Phe Pro Glu Thr Leu Leu Gly Asp Pro Glu Lys Arg 
         195                200                205
Thr Gln Tyr Phe Asp Pro Leu Arg Asn Glu Tyr Phe Phe Asp Arg Asn 
     210                215                220
Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr Gln Ser Gly Gly Arg 
 225                230                235                240
Leu Lys Arg Pro Val Asn Val Pro Phe Asp Ile Phe Thr Glu Glu Val 
                 245                250                255
Lys Phe Tyr Gln Leu Gly Glu Glu Ala Leu Leu Lys Phe Arg Glu Asp 
             260                265                270
Glu Gly Phe Val Arg Glu Glu Glu Asp Arg Ala Leu Pro Glu Asn Glu 
         275                280                285
Phe Lys Lys Gln Ile Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Asp 
     290                295                300
Pro Ala Arg Gly Ile Ala Ile Val Ser Val Leu Val Ile Leu Ile Ser 
 305                310                315                320
Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Phe Arg Asp Asp Arg 
                 325                330                335
Asp Leu Val Met Ala Leu Ser Ala Gly Gly His Gly Gly Leu Leu Asn 
             340                345                350
Asp Thr Ser Ala Pro His Leu Glu Asn Ser Gly His Thr Ile Phe Asn 
         355                360                365
Asp Pro Phe Phe Ile Val Glu Thr Val Cys Ile Val Trp Phe Ser Phe 
     370                375                380
Glu Phe Val Val Arg Cys Phe Ala Cys Pro Ser Gln Ala Leu Phe Phe 
 385                390                395                400
Lys Asn Ile Met Asn Ile Ile Asp Ile Val Ser Ile Leu Pro Tyr Phe 
                 405                410                415
Ile Thr Leu Gly Thr Asp Leu Ala Gln Gln Gln Gly Gly Gly Asn Gly 
             420                425                430
Gln Gln Gln Gln Ala Met Ser Phe Ala Ile Leu Arg Ile Ile Arg Leu 
         435                440                445
Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu 
     450                455                460
Gln Ile Leu Gly His Thr Leu Arg Ala Ser Met Arg Glu Leu Gly Leu 
 465                470                475                480
Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe Ser Ser Ala Val 
                 485                490                495
Tyr Phe Ala Glu Ala Asp Glu Pro Thr Thr His Phe Gln Ser Ile Pro 
             500                505                510
Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr Gly 
         515                520                525
Asp Met Lys Pro Ile Thr Val Gly Gly Lys Ile Val Gly Val Leu Cys 
     530                535                540
Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile Val 
 545                550                555                560
Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Glu Asn Glu Glu Gln 
                 565                570                575
Thr Gln Leu Thr Gln Asn Ala Val Ser Cys Pro Tyr Leu Pro Ser Asn 
             580                585                590
Leu Leu Lys Lys Phe Arg Ser Ser Thr Ser Ser Ser Leu Gly Asp Lys 
         595                600                605
Ser Glu Tyr Leu Glu Met Glu Glu Gly Val Lys Glu Ser Leu Cys Ala 
     610                615                620
Lys Glu Glu Lys Cys Gln Ala Lys Gly Asp Asp Ser Glu Thr Asp Lys 
 625                630                635                640
Asn Asn Cys Ser Asn Ala Lys Ala Val Glu Thr Asp Val 
                 645                650



<210> 9442
<211> 1087
<212> DNA
<213> Rattus norvegicus
<308> X16038
<400> 9442

caggccagt  tgggggtga  gaaaagggg  tatttctct  acggctctg  ggttcaggc  60
ggcacttaa  agatatttc  gacctacag  tcacaacaa  taccaggcc  agtccgctg  120
ccccctgcg  cacgagacc  acggtgggg  agatgtggc  gtctttgcc  agggcccta  180
ggctcacct  cttcacggc  tccatgagc  gaactacat  ccccacgtc  tggcgtatg  240
ctcctgcat  ggagccaac  ttgaccact  tgcctgggc  agctctgcg  gcagcccct  300
cccnggngc  ctgctgctt  cactggctc  gttccccct  cgcaccctg  tctgagggc  360
caggtccca  aagagccca  aatggacag  cggctcccc  ccctttgtg  cctgccacc  420
ggccgccca  actcaacgg  gaggcccag  caacctcga  caggaacag  agtttgcta  480
ctgcctcac  tccgcccgg  accctccgt  ggtcggatt  ctggctctg  cgttgtttc  540
ctattcact  ccttttggc  agcagggtg  gtttctctc  tgggccggc  ggacacaga  600
tgcgcagat  cccaaagca  cttattttt  taccaaata  actctccag  ccctgcaac  660
atcatggaa  attccagat  tgaccttct  tcccctacc  cttctctct  gaacactgg  720
tcccatagt  acagccagt  cctcaaccc  accctccct  gagggaaga  caggtctgc  780
cagggtgag  ctcccagga  gccacctcc  gggttggct  tctacccag  gtggccagg  840
tgggaagaa  aacccagcc  gacaggacg  acacactcc  cacccagct  cagagactc  900
ccaaccctt  actgaagcg  ctcccctgt  tggaatagc  aaaaaaaaa  agaaagaaa  960
aaaagaaaa  aattttaat  tctcttttt  gtgttggtt  aaagggaac  caagacatt  1020
aaataaaat  ttccaaata  ttctgaggc  agagctgag  ctttgtggt  agtgggaaa  1080
agaccaa  1087



<210> 9443
<211> 524
<212> PRT
<213> Rattus norvegicus
<308> NP_037191
<400> 9443

Met Ile Leu Pro Phe Leu Val Leu Ala Ile Gly Pro Cys Leu Thr Asn 
  1               5                  10                  15
Ser Phe Val Pro Glu Lys Glu Lys Asp Pro Ser Tyr Trp Arg Gln Gln 
             20                  25                  30
Ala Gln Glu Thr Leu Lys Asn Ala Leu Lys Leu Gln Lys Leu Asn Thr 
         35                  40                  45
Asn Val Ala Lys Asn Ile Ile Met Phe Leu Gly Asp Gly Met Gly Val 
     50                  55                  60
Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
 65                  70                  75                  80
Thr Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                 85                  90                  95
Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
             100                105                110
Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
         115                120                125
Gly Val Ser Ala Ala Thr Glu Arg Thr Arg Cys Asn Thr Thr Gln Gly 
     130                135                140
Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
 145                150                155                160
Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                 165                170                175
Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
             180                185                190
Arg Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
         195                200                205
Met His Asn Ile Lys Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
     210                215                220
Tyr Met Tyr Pro Lys Asn Arg Thr Asp Val Glu Tyr Glu Leu Asp Glu 
 225                230                235                240
Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Ile Ser Ile Trp 
                 245                250                255
Lys Ser Phe Lys Pro Arg His Lys His Ser His Tyr Val Trp Asn Arg 
             260                265                270
Thr Glu Leu Leu Ala Leu Asp Pro Ser Arg Val Asp Tyr Leu Leu Gly 
         275                280                285
Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Leu 
     290                295                300
Thr Asp Pro Ser Leu Ser Glu Met Val Glu Val Ala Leu Arg Ile Leu 
 305                310                315                320
Thr Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                 325                330                335
Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
             340                345                350
Val Glu Met Asp Glu Ala Ile Gly Lys Ala Gly Thr Met Thr Ser Gln 
         355                360                365
Lys Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
     370                375                380
Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
 385                390                395                400
Met Val Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                 405                410                415
Asn Gly Pro Gly Tyr Lys Val Val Asp Gly Glu Arg Glu Asn Val Ser 
             420                425                430
Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
         435                440                445
Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Lys 
     450                455                460
Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Ile 
 465                470                475                480
Pro His Val Met Ala Tyr Ala Ser Cys Ile Gly Ala Asn Leu Asp His 
                 485                490                495
Cys Ala Trp Ala Ser Ser Ala Ser Ser Pro Ser Pro Gly Ala Leu Leu 
             500                505                510
Leu Pro Leu Ala Leu Phe Pro Leu Arg Thr Leu Phe 
         515                520



<210> 9444
<211> 2590
<212> DNA
<213> Homo sapiens
<308> XM_001826
<400> 9444

agaaactcc  ggtgtggca  ctgagatgg  ccaggaaag  actatatta  cttcaaaaa  60
agaggtaca  gcgatgttt  aggtggcat  aagctcagt  gtgttatat  ggaatgagt  120
agtgaccat  ctggagcct  cctgaaaga  gattggaac  tcagttaac  tctgaccac  180
gccagccca  cccctccca  ccacgtcga  tgcatctct  ggctccagg  ataaagcag  240
tcttggggt  caccatgat  tcaccattc  tagtactgg  cattggcac  tgccttact  300
actccttag  gccagagaa  gagaaagac  ccaagtact  gcgagacca  gcgcaagag  360
cactgaaat  tgccctgga  cttcagaag  tcaacacca  cgtggctaa  aatgtcatc  420
tgttcctgg  agatgggat  ggtgtctcc  cagtgacgg  tgcccgcat  ctcaagggt  480
agctccacc  caaccctgg  gaggagacc  ggctggaga  ggacaagtt  cccttcgtg  540
ccctctcca  gacgtacaa  accaatgcc  aggtccctg  cagtgccgg  accgccacc  600
cctacctgt  tggggtgaa  gccaatgag  gcaccgtgg  ggtaagcgc  gccactgag  660
gttcccggt  caacaccac  caggggaac  aggtcacct  catcctgcg  tgggccaag  720
acgctggga  atctgtggg  attgtgacc  ccacgagag  gaaccatgc  acccccagc  780
ccgcctacg  ccactcggc  gaccgggac  ggtactcag  caacgagat  ccccctgag  840
ccttgagcc  gggctgtaa  gacatcgcc  accagctca  gcataacat  agggacatt  900
acgtgatca  ggggggtgg  cggaaatac  tgtacccca  gaataaaac  gatgtggag  960
atgagagtg  cgagaaagc  aggggcacg  ggctggacg  cctggacct  gttgacacc  1020
ggaagagct  caaaccgag  tacaagcac  cccacttca  ctggaaccg  acggaactc  1080
tgacccttg  cccccacaa  gtggactac  tattgggtc  cttcgagcc  ggggacatg  1140
agtacgagc  gaacaggaa  aacgtgacg  acccgtcac  ctccgagat  gtggtggtg  1200
ccatccaga  cctgcggaa  aaccccaaa  gcttcttct  gctggtgga  ggaggcaga  1260
ttgaccacg  gcaccatga  ggaaaagcc  agcaggccc  gcatgaggc  gtggagatg  1320
accgggcca  cgggcaggc  ggcagcttg  cctcctcgg  agacactct  accgtggtc  1380
ctgcggacc  ttcccacgt  ttcacattt  gtggataca  cccccgtgg  aactctatc  1440
ttggtctgg  ccccatgct  agtgacaca  acaagaagc  cttcactgc  atcctgtat  1500
gcaatgggc  tggctacaa  gtggtgggc  gtgaacgag  gaatgtctc  atggtggac  1560
atgctcaca  caactacca  gcgcagtct  ctgtgcccc  gcgccacga  acccacggc  1620
gggaggacg  ggccgtctt  tccaagggc  ccatggcgc  cctgctgca  ggcgtccac  1680
agcagaact  cgtccccca  gtgatggcg  atgcagcct  catcggggc  aacctcggc  1740
actgtgctc  tgccagctc  gcaggcagc  ttgctgcag  ccccctgct  ctcgcgctg  1800
ccctctacc  cctgagcgt  ctgttctga  ggcccaggg  ccgggcacc  acaagcccg  1860
gacagatgc  aacttccca  acggcagcc  ccccctcaa  gggcaggga  gtgggggcc  1920
cctcagcct  tgcaactgc  agaaagggg  cccaagaaa  caaagtctg  cgcccacct  1980
gctcccctc  ggaatcttc  ccaagggcc  aacccactt  tggcctcca  cctttgctc  2040
ctccccgct  ccctttggc  aacagggta  atttctctt  ggcaggcag  gagtacaga  2100
tgcagacat  ctcaaagcc  cttattttt  tagcgaacg  atttctcca  acccagagg  2160
cctgaagcc  ccgtggaac  ttctggatc  gaccctccc  gtctcatct  ctgaccctc  2220
cactcccat  tccttacct  tggaacccc  caggcccta  aatgctcat  tccctgtcc  2280
caggcccag  cctccttca  gggagttga  gtctttctc  tcaggacaa  gccttgctc  2340
ctcactcac  ccaagacca  cagggtccc  ggaagccgg  gcctgggtg  ccatcctac  2400
cagcgtggc  caggccggg  agagccacc  ggcagggct  acactcctg  gctctgaac  2460
cacacgcca  ctcctctct  aagcgactc  cctgtttgg  acggcaaaa  aaaattttt  2520
tttctcttt  tggtggtgg  taaaaggga  cacaaaaca  ttaaataaa  ctttccaaa  2580
atttccgagg  2590



<210> 9445
<211> 524
<212> PRT
<213> Homo sapiens
<308> XP_001826
<400> 9445

Met Ile Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
  1               5                  10                  15
Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
             20                  25                  30
Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr 
         35                  40                  45
Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
     50                  55                  60
Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
 65                  70                  75                  80
Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                 85                  90                  95
Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
             100                105                110
Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
         115                120                125
Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly 
     130                135                140
Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
 145                150                155                160
Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                 165                170                175
Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
             180                185                190
Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
         195                200                205
Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
     210                215                220
Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu 
 225                230                235                240
Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp 
                 245                250                255
Lys Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg 
             260                265                270
Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly 
         275                280                285
Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val 
     290                295                300
Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu 
 305                310                315                320
Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                 325                330                335
Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
             340                345                350
Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser 
         355                360                365
Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
     370                375                380
Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
 385                390                395                400
Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                 405                410                415
Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
             420                425                430
Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
         435                440                445
Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys 
     450                455                460
Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val 
 465                470                475                480
Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His 
                 485                490                495
Cys Ala Pro Ala Ser Ser Ala Gly Ser Leu Ala Ala Gly Pro Leu Leu 
             500                505                510
Leu Ala Leu Ala Leu Tyr Pro Leu Ser Val Leu Phe 
         515                520



<210> 9446
<211> 1738
<212> DNA
<213> Rattus norvegicus
<308> X16043
<400> 9446

cggagcaca  cggccgccg  gcactgcga  cgagcggcc  gcgccacgc  agcagccgc  60
tggggccgc  ggaagcacc  cggggagcg  cggcggcgt  tgcgtgtgg  gcgggtgcg  120
gcggcggcg  gggagcagg  cagagcggc  gccggttcg  gcgggcggc  tcatggacg  180
gaagttgtt  accaaggag  tggaccagt  gatcgagca  ctgaacgag  gcaagcagc  240
ctccgagtc  caggtcaag  gcctctgcg  gaaggctaa  gaaatcctt  caaaagaat  300
taatgttca  gaggttcga  gtccagtta  tgtgtgtgg  gatgtgcat  ggcaatttc  360
tgacctcat  gaactcttt  gaattggtg  taaatcacc  gatacaaat  acttgttta  420
gggagacta  gtggacaga  gatattact  agttgaaac  gttacactg  ttgtagctc  480
taaggttcg  taccgagag  gtatcacca  actccgagg  aatcacgag  gcagacaga  540
cacacaagt  tatggtttc  acgatgagt  tttaaggaa  tacggaaat  caaatgttt  600
gaaatactt  acagacctt  ttgactacc  tcctctcac  gccttggtg  atgggcaga  660
cttctgtct  catggtggt  tttcaccat  catagacac  ctggatcac  tccgagcac  720
tgatcgcct  caagaagtt  ctcatgagg  tccaatgtg  gacttgctg  ggtcagatc  780
agatgaccg  ggtggctgg  ggatatctc  tcggggagc  ggttatacc  ttggccaag  840
tatttctga  acatttaat  atgccaatg  cctcacgtt  gtgtccaga  ctcaccagc  900
ggtgatgga  ggatataac  ggtgccatg  ccggaatgt  gtaacaatt  tcagtgctc  960
aaactattg  tatcgttgt  gtaaccaag  tgcaatcat  gaacttgat  acactctta  1020
gtattcttt  ttgcagttc  atccagcac  tcgtagagg  gagccacat  tcactcgtc  1080
taccccaga  tacttcctg  aatgaaagt  taaccttgt  cagtattgc  atgaacacc  1140
tctgttgac  taatggaat  ggaagagca  cagtaactc  aaagtgtca  aaatagtta  1200
cattcaaac  tgtttccac  cggaccaaa  gatgtgcca  ataaaatac  aagcctctt  1260
tcatcaaca  ccgtgacca  tttagaatg  accagttca  tgcatgctg  cgcgacatt  1320
ttggtcaag  atccagttt  tggcatagc  ctatttgta  ttacttttg  tttcttgag  1380
gactgcaga  ctaggatgt  acattaaca  ctgtgagtc  agttgactt  cacttagct  1440
tagcttact  agcatgact  tagagagga  agcaaacaa  cattggagc  taatgaaca  1500
ttttaaatg  gtaccaagg  ctcccctct  gttgtgttc  ttcagggat  ctattaatt  1560
aattgtatg  tttctctgc  ctcagtttc  cccttctca  atctcggcc  gcgttgttc  1620
ttgttactg  cagaaaacc  ggtgagttg  ttgaacaga  ctgtctcct  ctgtaagat  1680
atgtactgc  aagtacgca  tgtttcata  taaacttga  actgagaag  cagggttt  1738



<210> 9447
<211> 309
<212> PRT
<213> Rattus norvegicus
<308> CAA34166
<400> 9447

Met Asp Glu Lys Leu Phe Thr Lys Glu Leu Asp Gln Trp Ile Glu Gln 
  1               5                  10                  15
Leu Asn Glu Cys Lys Gln Leu Ser Glu Ser Gln Val Lys Ser Leu Cys 
             20                  25                  30
Glu Lys Ala Lys Glu Ile Leu Thr Lys Glu Ser Asn Val Gln Glu Val 
         35                  40                  45
Arg Cys Pro Val Thr Val Cys Gly Asp Val His Gly Gln Phe His Asp 
     50                  55                  60
Leu Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr 
 65                  70                  75                  80
Leu Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr 
                 85                  90                  95
Val Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr 
             100                105                110
Ile Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly 
         115                120                125
Phe Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys 
     130                135                140
Tyr Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp 
 145                150                155                160
Gly Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr 
                 165                170                175
Leu Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu 
             180                185                190
Gly Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly 
         195                200                205
Trp Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile 
     210                215                220
Ser Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala 
 225                230                235                240
His Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val 
                 245                250                255
Val Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln 
             260                265                270
Ala Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln 
         275                280                285
Phe Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr 
     290                295                300
Pro Asp Tyr Phe Leu 
 305



<210> 9448
<211> 2181
<212> DNA
<213> Homo sapiens
<308> NM_002715
<400> 9448

agagagccg  gctctggag  ctcagcgag  ggaggagga  gcgcagggc  gacggccga  60
tactgcggt  agagccagc  ggccagcgc  agcctcaac  gccgccaga  gtacacgag  120
aaccggcgg  ggcgtgtgc  tgtaggccc  tgtgcgggc  gcggcgcgg  aggagcgcg  180
agcggcagc  ggctggggc  ggtggcatc  tggacgaga  ggtgttcac  aaggagctg  240
accagtgga  cgagcagct  aacgagtgc  agcagctgt  cgagtccca  gtcaagagc  300
tctgcgaga  ggctaaaga  atcctgaca  aagaatcca  cgtgcaaga  gttcgatgt  360
cagttactg  ctgtggaga  gtgcatggg  aatttcatg  tctcatgga  ctgtttaga  420
ttggtggca  atcaccaga  acaaattac  tgtttatgg  agattatgt  gacagagga  480
attattcag  tgaaacagt  acactgctt  tagctctta  ggttcgtta  cgtgaacgc  540
tcaccattc  tcgagggaa  catgagagc  gacagatca  acaagttta  ggtttctat  600
atgaatgtt  aagaaaata  ggaaatgca  atgtttgga  atattttac  gatcttttt  660
actatcttc  tctcactgc  ttggtggat  ggcagatct  ctgtctaca  ggtggtctc  720
cgccatcta  agatacact  gatcatatc  gagcacttg  tcgcctaca  gaagttccc  780
atgagggtc  aatgtgtga  ttgctgtgg  cagatccag  tgaccgtgg  ggttggggt  840
tatctcctc  aggagctgg  tacaccttt  ggcaagata  ttctgagac  tttaatcat  900
ccaatggcc  cacgttggt  tctagagct  accagctag  gatggaggg  tataactgg  960
gccatgacc  gaatgtagt  acgattttc  gtgctccaa  ctattgtta  cgttgtggt  1020
accaagctg  aatcatgga  cttgacgat  ctctaaaat  ctctttctt  cagtttgac  1080
cagcacctc  tagaggcga  ccacatgtt  ctcgtcgta  cccagacta  ttcctgtaa  1140
gaaatttta  acttgtaca  tattgccat  aaccatata  cgacctaat  gaaatggga  1200
gagcaacag  aactccaaa  tgtcagaaa  tagttaaca  tcaaaaaac  tgttttcac  1260
tggaccaaa  gatgtgcca  ataaaaata  aaagcctct  gtcatcaac  gccgtgacc  1320
ctttagaat  aaccagttc  ttgcatgct  aagcgacat  gttggtcaa  aaaccagtt  1380
ctggcatag  gctatttgt  gttactttt  ctttctctg  gagactgca  ataataaga  1440
gtaaacatt  acacctcgt  aatacaatt  aacttccat  tagctatag  tttactcag  1500
atgactgta  ataaggata  cagcaaaca  tcattggag  ttaatgaac  tttttaaaa  1560
taattacca  ggcctccct  ctacttgtg  gttttgaaa  tgttctttt  attttcagg  1620
ataccgttt  atttaatta  atgatttgt  tgcactcag  ttattccct  ctcaaatct  1680
agccccatg  tgttctttg  tattgtcag  acctggtga  ttgttttga  cagaactgt  1740
ttttcccct  cctgtaaga  gatgtgact  cacaagagc  ctgcagtgt  tttcataat  1800
aacttgtga  ctaagaact  agaaggtca  attttaatt  tatcaatgg  caagactgg  1860
gctgtttat  aaaaaagtt  aatcaattg  gtaaatttt  gaatttgta  acttgtagg  1920
aaaataaaa  tcaagggca  tacataacc  ctctggtaa  tccttgaca  tcttcagat  1980
aacttcagg  tttatttgt  tttcacata  tacaatttg  cacattgtt  gtgtgcact  2040
tgtgggttc  tcctgcata  taacttgtt  gtaagaaag  aaatctgtg  tgcttcagt  2100
agacttaat  gtaaaacca  ataacttga  atttaagtc  ttgggttgt  ttttaataa  2160
acagcatgt  ttcaggtag  g  2181



<210> 9449
<211> 309
<212> PRT
<213> Homo sapiens
<308> P05323
<400> 9449

Met Asp Glu Lys Val Phe Thr Lys Glu Leu Asp Gln Trp Ile Glu Gln 
  1               5                  10                  15
Leu Asn Glu Cys Lys Gln Leu Ser Glu Ser Gln Val Lys Ser Leu Cys 
             20                  25                  30
Glu Lys Ala Lys Glu Ile Leu Thr Lys Glu Ser Asn Val Gln Glu Val 
         35                  40                  45
Arg Cys Pro Val Thr Val Cys Gly Asp Val His Gly Gln Phe His Asp 
     50                  55                  60
Leu Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr 
 65                  70                  75                  80
Leu Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr 
                 85                  90                  95
Val Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr 
             100                105                110
Ile Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly 
         115                120                125
Phe Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys 
     130                135                140
Tyr Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp 
 145                150                155                160
Gly Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr 
                 165                170                175
Leu Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu 
             180                185                190
Gly Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly 
         195                200                205
Trp Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile 
     210                215                220
Ser Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala 
 225                230                235                240
His Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val 
                 245                250                255
Val Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln 
             260                265                270
Ala Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln 
         275                280                285
Phe Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr 
     290                295                300
Pro Asp Tyr Phe Leu 
 305



<210> 9450
<211> 735
<212> DNA
<213> Rattus norvegicus
<308> X16072
<400> 9450

gtcacctcg  caccagaga  tccaccatg  cctcagacc  ccagacaca  gcgggcaag  60
cccagcccc  taaccctaa  atcatcatc  tcgaacagg  gaacttcca  ggccattcc  120
atgagctca  cgggccctg  cccaacctg  aggagactg  gatggagaa  gcaggctcc  180
tcctggtgc  ggctggacc  tgggtgggc  acgagcagg  taattgcaa  ggagagcag  240
ttgtgtttg  gaagggcga  tacccacgc  gggactcct  gaccagcag  cggaggacg  300
actccctca  ttctctgag  cccatcaaa  tggacagcc  ggagcacaa  atcatctta  360
atgagaacc  caactttac  ggcaagaag  tggagattg  cgatgatga  gtacccagc  420
ttcacgctc  cggatacca  gaaaaagtg  cttccgtgc  cgtgcagag  ggcacgtgg  480
ttgggtatc  gtaccctgg  taccgtggg  tgcagtatc  gctggagaa  ggggattac  540
aggacaaca  cgacttcgg  gcccctcac  cccaggtgc  atctgtgcg  cgcatccgt  600
acatgcagt  gcaccagcg  ggcgccttc  acccctcca  ctaaagccc  gcccctccc  660
ccttcccag  gtccaggcc  gccaccggg  tcctcctga  acccagagt  aataaagtg  720
ggcttgcaa  ttgaa  735



<210> 9451
<211> 204
<212> PRT
<213> Rattus norvegicus
<308> P26775
<400> 9451

Ala Ser Asp His Gln Thr Gln Ala Gly Lys Pro Gln Pro Leu Asn Pro 
  1               5                  10                  15
Lys Ile Ile Ile Phe Glu Gln Glu Asn Phe Gln Gly His Ser His Glu 
             20                  25                  30
Leu Ser Gly Pro Cys Pro Asn Leu Lys Glu Thr Gly Met Glu Lys Ala 
         35                  40                  45
Gly Ser Val Leu Val Gln Ala Gly Pro Trp Val Gly Tyr Glu Gln Ala 
     50                  55                  60
Asn Cys Lys Gly Glu Gln Phe Val Phe Glu Lys Gly Glu Tyr Pro Arg 
 65                  70                  75                  80
Trp Asp Ser Trp Thr Ser Ser Arg Arg Thr Asp Ser Leu Ser Ser Leu 
                 85                  90                  95
Arg Pro Ile Lys Val Asp Ser Gln Glu His Lys Ile Ile Leu Tyr Glu 
             100                105                110
Asn Pro Asn Phe Thr Gly Lys Lys Met Glu Ile Val Asp Asp Asp Val 
         115                120                125
Pro Ser Phe His Ala His Gly Tyr Gln Glu Lys Val Ser Ser Val Arg 
     130                135                140
Val Gln Ser Gly Thr Trp Val Gly Tyr Gln Tyr Pro Gly Tyr Arg Gly 
 145                150                155                160
Leu Gln Tyr Leu Leu Glu Lys Gly Asp Tyr Lys Asp Asn Ser Asp Phe 
                 165                170                175
Gly Ala Pro His Pro Gln Val Gln Ser Val Arg Arg Ile Arg Asp Met 
             180                185                190
Gln Trp His Gln Arg Gly Ala Phe His Pro Ser Ser 
         195                200



<210> 9452
<211> 589
<212> DNA
<213> Homo sapiens
<308> AI700368
<400> 9452

gagcactta  tggtttctt  tttattata  gttctggga  acatgtgca  aacgtgcag  60
tttgttaca  aggtataca  gtgccatgg  ggtttgctg  acccatcaa  ctgtcatct  120
ggttttaag  cgtgcatgc  tttggtatt  gtcccaatg  tctctctcc  tcttgtccc  180
cactccctg  caggcctcg  tgtgtgatg  tcccctcct  gtgtccatg  gttctcact  240
ttcaactcc  acttatgag  gagaacatg  ggtgtttgg  tttctgctt  tgtgttagt  300
tgctgagaa  gatggtttc  agcttcatc  atgtccctg  gggtgacgg  ccccaaagt  360
gctgctgtc  ttgtagtct  ccttctcca  caggtactg  agcccacgg  agccagggt  420
ctagtagcc  acccacatg  cactccgca  ccacacaga  gacaccttt  tctggtagc  480
attggcgtg  aagctggta  atcgtcatc  atgatttcc  tcctctttc  cggtgaagt  540
ggggtttta  taaagatga  cttgtgctc  gggctgtca  tttgatggg  589



<210> 9453
<211> 1478
<212> DNA
<213> Rattus norvegicus
<308> X16145
<400> 9453

cggaagcag  gatgtggga  ctgaaaagt  agtggtggg  ggtgggctt  gggcttctg  60
tgctactgg  agcttcggc  caggcaggg  gcttggctc  gcaccacta  actccggac  120
ggccgagct  ggactcgcg  ccactgccg  gatggttcg  cgaggccaa  ttcgggttg  180
tcgtgcatt  gggggtgta  tcggtgccc  cctggggca  cgagtggtt  tggtggcac  240
ggcagggcg  gcagtcgtc  gcgtacgtg  gcttcatga  agaaaacta  ccgcccggc  300
tcagctacg  cgactttgc  ccgcagttt  cagcgcgct  cttccatcc  gaggagtgg  360
cagacctct  ccaggctgc  ggggccaag  atgtcgtcc  gaccgcaaa  catcacgaa  420
gcttcacaa  ctggccaag  gccgtgtct  ggaactgga  ctcgaagga  gtggggccc  480
accgtgatt  ggtcggtga  ttgggagca  ctgtgcgga  gaggaacat  cgatacggc  540
tctaccact  gctctttga  tggttccat  cactctacc  actagataa  aaaaatggc  600
tcaagactc  gcatttcgt  agtacaaaa  caatgccag  gctgtacga  ctcgtgaat  660
ggtacaagc  tgacctaat  tggtctgat  gggagtggg  gtgtcccga  tcgtactgg  720
actccacgg  gttccttgc  tggctctac  atgaaagcc  ggtcaagga  caggtggta  780
tgaatgacc  gtggggtca  aactgctcc  gtcgtcacg  agggtacta  aactgtgaa  840
acaaataca  accacacag  ctgccagac  acaagtggg  gatgtgcac  agcgttgac  900
aggcgtcct  gggctatcg  agagacatg  gcatgtcta  catcgtcga  gaaaatgaa  960
tcattgagg  attggttca  acaataagt  tgggaggca  ctatcttct  aacatcgga  1020
cgaataaag  cggcgtgat  gtccccatc  tccaggaaa  gctccttgc  gttggcaag  1080
ggctgcaga  caacgggga  gccatctat  cctccaaac  atggagggt  cagtctgaa  1140
ggaacaaga  agttgtgtg  tacaccact  aagactcgg  tgtttatgc  acttttctg  1200
actggccag  agatggagt  gtaaacctc  aatctccca  aatgacatc  gccacaaag  1260
taacgatgc  aggaatgga  ggagaactg  actggaccc  ggacccact  gaaggcgtc  1320
tcatcactc  gccccagtt  ccaccaggc  ctttcccag  ggagtctgc  tggactcta  1380
agctgacaa  agtgaactg  tcgcaggag  tcaaggata  agggcccag  gtgctgctg  1440
ctcttaagg  ttatcgtga  taaagtagc  tcctttcc  1478



<210> 9454
<211> 462
<212> PRT
<213> Rattus norvegicus
<308> P17164
<400> 9454

Met Trp Asp Leu Lys Ser Glu Trp Trp Ala Val Gly Phe Gly Leu Leu 
  1               5                  10                  15
Leu Leu Leu Ala Ala Ser Ala Gln Ala Gly Gly Leu Ala Pro His His 
             20                  25                  30
Tyr Thr Pro Asp Trp Pro Ser Leu Asp Ser Arg Pro Leu Pro Arg Trp 
         35                  40                  45
Phe Asp Glu Ala Lys Phe Gly Leu Phe Val His Trp Gly Val Tyr Ser 
     50                  55                  60
Val Pro Ala Trp Gly Ser Glu Trp Phe Trp Trp His Trp Gln Gly Glu 
 65                  70                  75                  80
Gln Ser Ser Ala Tyr Val Arg Phe Met Lys Glu Asn Tyr Pro Pro Gly 
                 85                  90                  95
Phe Ser Tyr Ala Asp Phe Ala Pro Gln Phe Thr Ala Arg Phe Phe His 
             100                105                110
Pro Glu Glu Trp Ala Asp Leu Phe Gln Ala Ala Gly Ala Lys Tyr Val 
         115                120                125
Val Leu Thr Ala Lys His His Glu Gly Phe Thr Asn Trp Pro Ser Ala 
     130                135                140
Val Ser Trp Asn Trp Asn Ser Lys Asp Val Gly Pro His Arg Asp Leu 
 145                150                155                160
Val Gly Glu Leu Gly Ala Ala Val Arg Lys Arg Asn Ile Arg Tyr Gly 
                 165                170                175
Leu Tyr His Ser Leu Phe Glu Trp Phe His Pro Leu Tyr Leu Leu Asp 
             180                185                190
Lys Lys Asn Gly Leu Lys Thr Gln His Phe Val Ser Thr Lys Thr Met 
         195                200                205
Pro Glu Leu Tyr Asp Leu Val Asn Arg Tyr Lys Pro Asp Leu Ile Trp 
     210                215                220
Ser Asp Gly Glu Trp Glu Cys Pro Asp Ser Tyr Trp Asn Ser Thr Glu 
 225                230                235                240
Phe Leu Ala Trp Leu Tyr Asn Glu Ser Pro Val Lys Asp Gln Val Val 
                 245                250                255
Val Asn Asp Arg Trp Gly Gln Asn Cys Ser Cys Arg His Gly Gly Tyr 
             260                265                270
Tyr Asn Cys Glu Asp Lys Tyr Arg Pro His Ser Leu Pro Asp His Lys 
         275                280                285
Trp Glu Met Cys Thr Ser Val Asp Lys Ala Ser Trp Gly Tyr Arg Arg 
     290                295                300
Asp Met Ser Met Ser Thr Ile Val Asp Glu Asn Glu Ile Ile Glu Glu 
 305                310                315                320
Leu Val Gln Thr Ile Ser Leu Gly Gly Asn Tyr Leu Leu Asn Ile Gly 
                 325                330                335
Pro Asn Lys Asp Gly Val Ile Val Pro Ile Phe Gln Glu Arg Leu Leu 
             340                345                350
Ala Val Gly Lys Trp Leu Gln Ile Asn Gly Glu Ala Ile Tyr Ala Ser 
         355                360                365
Lys Pro Trp Arg Val Gln Ser Glu Arg Asn Lys Thr Val Val Trp Tyr 
     370                375                380
Thr Thr Lys Asp Ser Ala Val Tyr Ala Thr Phe Leu His Trp Pro Glu 
 385                390                395                400
Asp Gly Val Val Asn Leu Gln Ser Pro Lys Met Thr Ser Ala Thr Lys 
                 405                410                415
Ile Thr Met Leu Gly Met Glu Gly Glu Leu His Trp Thr Gln Asp Pro 
             420                425                430
Leu Glu Gly Val Leu Ile Thr Leu Pro Gln Leu Pro Pro Gly Thr Phe 
         435                440                445
Pro Val Glu Ser Ala Trp Thr Leu Lys Leu Thr Lys Val Asn 
     450                455                460



<210> 9455
<211> 2065
<212> DNA
<213> Homo sapiens
<308> BC017338
<400> 9455

ggcacgagg  tagcgatgc  ggctccggg  atgaggtcg  ggccggcgg  tcccgcgct  60
ttgctgctg  tgctcttcc  cggagcggc  gagtcggtg  gtcgggccc  gcctccgcg  120
cgctacacc  cagactggc  gagcctgga  tctcggccg  tgccggcct  gttcgacga  180
gccaagttc  gggtgttca  ccactgggg  gtgttctcg  tgcccgcct  gggcagcga  240
tggttctgg  ggcactggc  gggcgaggg  cggccgcag  accagcgct  catgcgcga  300
aactacccg  ccggcttca  ctacgccga  ttcggaccg  agttcactg  gcgcttctt  360
cacccggag  agtgggccg  cctcttcca  gccgcgggc  ccaagtatg  agttttgac  420
acaaagcat  acgaaggct  cacaaactg  ccgagtcct  tgtcttgga  ctggaactc  480
aaagacgtg  ggcctcatc  ggatttggt  ggtgaattg  gaacagctc  ccggaagag  540
aacatccgc  atggactat  ccactcact  ttagagtgg  tccatccac  ctatctact  600
gataagaaa  atggcttca  aacacagca  tttgtcagt  caaaaacaa  gccagagct  660
tacgacctt  ttaacagct  taaacctga  ctgatctgg  ctgatgggg  gtgggaatg  720
cctgatact  actggaact  cacaaattt  ctttcatgg  tctacaatg  cagccctgt  780
aaggatgag  tggtagtaa  tgaccgatg  ggtcagaac  gttcctgtc  ccatggagg  840
tactataac  gtgaagata  attcaagcc  cagagcttg  cagatcaca  gtgggagat  900
tgcaccagc  ttgacaagt  ttcctgggg  tatcgtcgt  acatggcat  gtctgatgt  960
acagaagaa  ctgaaatca  ttcggaact  gttcagaca  taagtttgg  aggcaacta  1020
cttctgaac  ttggaccaa  taaagatgg  ctgattgtt  ccatcttcc  agaaaggct  1080
cttgctgtt  ggaaatggc  gagcatcaa  ggggaggct  tctatgcct  caaaccatg  1140
cgggtgcaa  gggaaaaga  cacaacatc  gtatggtat  cctcaaagg  atcggctgt  1200
tatgccatt  ttctgcact  gccagaaaa  ggagtctta  accttgaat  ccccataac  1260
acctcaact  caaagataa  aatgctggg  attcaagga  atctgaagt  gtccacaga  1320
ccagataaa  gtctcttca  ctctctacc  cagttgcca  cctctgctg  ccccgcaga  1380
tttgcttgg  ctataaagc  gacaggagt  aagtaatca  ttgagtgca  gaagaaaga  1440
gcgctgctc  ctgttttcc  gcttcagtt  ttctcttat  gtaccatca  tataatcaa  1500
gaacttctc  tctccaccc  gagatggct  ttccaacac  ttttaatta  aggaactga  1560
tacattacc  tgatgtcta  atggaccaa  gatctgaga  ccattgtga  tatatctgt  1620
tcaggtcag  agaagaagg  actgagcag  tgaactctg  gttcatcaa  tgtaatatt  1680
ggaaattat  tacaatgga  tcttccctc  gttctctga  aacctactt  cttactcaa  1740
gcctttaag  caagtcacc  tgttgccta  gggaggagg  ggaaggatt  ggcaagctc  1800
accacatgc  atttagtta  catcagttg  caccaacag  ctttctgca  agggcagga  1860
agctttggg  gaaaggaaa  ggcttacca  gctgctatg  tcaactctt  agaaatttt  1920
agagcaatc  aaaagcgcc  aaattcgct  tgtttacag  gatactatt  agaaaatga  1980
tgtgattct  ctctgtctt  ttaagtatg  tcaaataaa  aatttgtac  tcacaatca  2040
ttctaccaa  aaaaaaaaa  aaaaa  2065



<210> 9456
<211> 461
<212> PRT
<213> Homo sapiens
<308> P04066
<400> 9456

Met Arg Ser Arg Pro Ala Gly Pro Ala Leu Leu Leu Leu Leu Leu Phe 
  1               5                  10                  15
Leu Gly Ala Ala Glu Ser Val Arg Arg Ala Gln Pro Pro Arg Arg Tyr 
             20                  25                  30
Thr Pro Asp Trp Pro Ser Leu Asp Ser Arg Pro Leu Pro Ala Trp Phe 
         35                  40                  45
Asp Glu Ala Lys Phe Gly Val Phe Ile His Trp Gly Val Phe Ser Val 
     50                  55                  60
Pro Ala Trp Gly Ser Glu Trp Phe Trp Trp His Trp Gln Gly Glu Gly 
 65                  70                  75                  80
Arg Pro Gln Tyr Gln Arg Phe Met Arg Asp Asn Tyr Pro Pro Gly Phe 
                 85                  90                  95
Ser Tyr Ala Asp Phe Gly Pro Gln Phe Thr Ala Arg Phe Phe His Pro 
             100                105                110
Glu Glu Trp Ala Asp Leu Phe Gln Ala Ala Gly Ala Lys Tyr Val Val 
         115                120                125
Leu Thr Thr Lys His His Glu Gly Phe Thr Asn Trp Pro Ser Pro Val 
     130                135                140
Ser Trp Asn Trp Asn Ser Lys Asp Val Gly Pro His Arg Asp Leu Val 
 145                150                155                160
Gly Glu Leu Gly Thr Ala Leu Arg Lys Arg Asn Ile Arg Tyr Gly Leu 
                 165                170                175
Tyr His Ser Leu Leu Glu Trp Phe His Pro Leu Tyr Leu Leu Asp Lys 
             180                185                190
Lys Asn Gly Phe Lys Thr Gln His Phe Val Ser Ala Lys Thr Met Pro 
         195                200                205
Glu Leu Tyr Asp Leu Val Asn Ser Tyr Lys Pro Asp Leu Ile Trp Ser 
     210                215                220
Asp Gly Glu Trp Glu Cys Pro Asp Thr Tyr Trp Asn Ser Thr Asn Phe 
 225                230                235                240
Leu Ser Trp Leu Tyr Asn Asp Ser Pro Val Lys Asp Glu Val Val Val 
                 245                250                255
Asn Asp Arg Trp Gly Gln Asn Cys Ser Cys His His Gly Gly Tyr Tyr 
             260                265                270
Asn Cys Glu Asp Lys Phe Lys Pro Gln Ser Leu Pro Asp His Lys Trp 
         275                280                285
Glu Met Cys Thr Ser Ile Asp Lys Phe Ser Trp Gly Tyr Arg Arg Asp 
     290                295                300
Met Ala Leu Ser Asp Val Thr Glu Glu Ser Glu Ile Ile Ser Glu Leu 
 305                310                315                320
Val Gln Thr Val Ser Leu Gly Gly Asn Tyr Leu Leu Asn Ile Gly Pro 
                 325                330                335
Thr Lys Asp Gly Leu Ile Val Pro Ile Phe Gln Glu Arg Leu Leu Ala 
             340                345                350
Val Gly Lys Trp Leu Ser Ile Asn Gly Glu Ala Ile Tyr Ala Ser Lys 
         355                360                365
Pro Trp Arg Val Gln Trp Glu Lys Asn Thr Thr Ser Val Trp Tyr Thr 
     370                375                380
Ser Lys Gly Ser Ala Val Tyr Ala Ile Phe Leu His Trp Pro Glu Asn 
 385                390                395                400
Gly Val Leu Asn Leu Glu Ser Pro Ile Thr Thr Ser Thr Thr Lys Ile 
                 405                410                415
Thr Met Leu Gly Ile Gln Gly Asp Leu Lys Trp Ser Thr Asp Pro Asp 
             420                425                430
Lys Gly Leu Phe Ile Ser Leu Pro Gln Leu Pro Pro Ser Ala Val Pro 
         435                440                445
Ala Glu Phe Ala Trp Thr Ile Lys Leu Thr Gly Val Lys 
     450                455                460



<210> 9457
<211> 2348
<212> DNA
<213> Rattus norvegicus
<308> X16262
<400> 9457

ctggatgag  agatggaag  taagcaaaa  cttgagcgc  atgtctcca  cttgaacat  60
cagctctca  actctaaga  gaagctgca  gaccttgca  gcactattg  ggtcatgga  120
gaggggaag  agaggttgc  gaaagagat  gagggtctc  gccagcagt  tgaggagaa  180
gccgctgcc  atgacaaac  ggagaaaac  aagaacagg  ttcagcagg  gctagatga  240
ttggtcgtg  acttggaca  ccagcggca  ctggtatcc  atctggaaa  gaagcagaa  300
aaattcgat  agttgttag  tgaggaaaa  aacatctcc  ccaagtatg  ggatgagag  360
gaccgagct  aagcagagg  cagggaaaa  gaaacgaag  ctttgtctc  ggcccgggc  420
ctggaggaa  ccctggaag  caaagagga  ctggaaagg  ccaacaaga  gctcaaggc  480
gagatggaa  acctggtca  ctccaagga  gacgtgggc  agaatgtgc  cgagctgga  540
aagtccaaa  gagccctgg  gacccagat  gaagagatg  gaactcagc  agaggagct  600
gaggacgag  tgcaggcca  tgaagacgc  aagctgcgg  tggaggtca  catgcaggc  660
ctcaagggc  agtttgaac  agatctcca  gctcgggat  agcagaatg  ggagaagag  720
aggcagcta  agcggcagc  gcatgagta  gagacagaa  tggaagatg  acggaagca  780
agggctctg  cggcagcag  caagaagaa  ctggaaggg  atctgaaag  cctggaact  840
caggctgac  cagccgtca  agggaggga  gaagccatc  agcagcttc  aaaactgca  900
gctcagatg  aggacttcc  aagagagct  gatgatgcc  gtgcctcca  agatgagat  960
tttgccacc  caaaagaga  tgagaagaa  gccaagagt  tggaggcag  gctcatgca  1020
ctccaggag  acctggcag  agctgagag  gctcgcaag  aagctgacc  ggagaagga  1080
gagctggct  aggagctgg  tagcagctt  tcaggaagg  atacactgc  ggatgagaa  1140
cgccgcctg  aggcaagga  cgcccagct  gaggaggag  tggaggaag  gcagggcaa  1200
atggaggcc  tgagtgaca  agtccgcaa  gccacattg  aggctgagc  actgagcaa  1260
gagctggtc  ctgagcgca  tgcagctca  aagaatgag  gtgcacggc  acagctgga  1320
cgccagaac  aggaactcc  aagcaagtt  caggaggta  aaggtgctg  caaagccaa  1380
cttaagtcc  ctgttgcgg  actagaggc  aagattgtg  agctggagg  gcagattga  1440
caagaggcc  gagaaaaac  ggcagccac  aagttgctg  agcaaaagg  caagaagct  1500
aaggaggtc  tactgcagg  ggaggatga  cgcaagatg  tggagcagt  caaggagca  1560
gcagagaaa  gaaacacca  ggtcaagca  ctcaagagg  agctggaag  ggccgagga  1620
gaatcccag  gcatcaatg  caaccgcag  aagctgcag  gggagctgg  tgaggccac  1680
gagagcaat  aggccatgg  ccgtgaggt  aatgccctc  agagcaaac  caggagagg  1740
aacgaggct  catttgttc  ttccagaag  gctggaggc  gtagagtta  tgaaaacac  1800
gatggttct  aagaagaaa  ggatgctcg  gactcagac  tcaatggaa  caaagccag  1860
gaataaatt  agttggaca  tatgtcagg  aaaacaaaa  accaaatga  agcaaagcc  1920
agcaggctg  ttagcattt  tctccattc  ttctcaagt  atagacatt  ccccacctc  1980
caccaggag  caaccacag  cctgcacaa  ggatgtgaa  ttaagtttt  aaatgtgct  2040
ccagagaaa  tccagatag  tgcaggtcg  gagctgcag  cgccagtgc  tttgtttac  2100
tgaaatgga  cgttacgtg  atgggtgcc  cagcgccaa  ccgctccca  ccatcaact  2160
cctgacctt  cagtttggg  ggaaaacct  tttgaaaat  cccctccct  tcctgcctg  2220
acacctcag  cacacagtt  actaagacc  agtgacttt  tcagtcatc  gaattaagg  2280
agagcagag  gagcgcacc  ccttatttg  acccacgga  actttcacg  ataaaaggt  2340
ttaagtca  2348



<210> 9458
<211> 1976
<212> PRT
<213> Rattus norvegicus
<308> Q9JLT0
<400> 9458

Met Ala Gln Arg Thr Gly Leu Glu Asp Pro Glu Arg Tyr Leu Phe Val 
  1               5                  10                  15
Asp Arg Ala Val Ile Tyr Asn Pro Ala Thr Gln Ala Asp Trp Thr Ala 
             20                  25                  30
Lys Lys Leu Val Trp Ile Pro Ser Glu Arg His Gly Phe Glu Ala Ala 
         35                  40                  45
Ser Ile Lys Glu Glu Arg Gly Asp Glu Val Met Val Glu Leu Ala Glu 
     50                  55                  60
Asn Gly Lys Lys Ala Met Val Asn Lys Asp Asp Ile Gln Lys Met Asn 
 65                  70                  75                  80
Pro Pro Lys Phe Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu 
                 85                  90                  95
Asn Glu Ala Ser Val Leu His Asn Leu Lys Asp Arg Tyr Tyr Ser Gly 
             100                105                110
Leu Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val Ile Asn Pro Tyr 
         115                120                125
Lys Asn Leu Pro Ile Tyr Ser Glu Asn Ile Ile Glu Met Tyr Arg Gly 
     130                135                140
Lys Lys Arg His Glu Lys Pro Pro His Ile Tyr Ala Ile Ser Glu Ser 
 145                150                155                160
Ala Tyr Arg Cys Met Leu Gln Asp Arg Lys Asp Gln Ser Ile Leu Cys 
                 165                170                175
Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile 
             180                185                190
Gln Tyr Leu Ala His Val Ala Ser Ser His Lys Gly Arg Lys Asp His 
         195                200                205
Asn Ile Pro Gly Glu Leu Glu Arg Gln Leu Leu Gln Ala Asn Pro Ile 
     210                215                220
Leu Glu Ser Phe Gly Asn Ala Lys Thr Val Lys Asn Asp Asn Ser Ser 
 225                230                235                240
Arg Phe Gly Lys Phe Ile Arg Ile Asn Phe Asp Val Thr Gly Tyr Ile 
                 245                250                255
Val Gly Ala Asn Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg Ala Val 
             260                265                270
Arg Gln Ala Lys Asp Glu Arg Thr Phe His Ile Phe Tyr Gln Leu Leu 
         275                280                285
Ser Gly Ala Gly Glu His Leu Lys Ser Asp Leu Leu Leu Glu Gly Phe 
     290                295                300
Asn Asn Tyr Arg Phe Leu Ser Asn Gly Tyr Ile Pro Ile Pro Gly Gln 
 305                310                315                320
Gln Asp Lys Asp Asn Phe Gln Glu Thr Met Glu Ala Met His Ile Met 
                 325                330                335
Gly Phe Ser His Glu Glu Ile Leu Ser Met Leu Lys Val Val Ser Ser 
             340                345                350
Val Leu Gln Phe Gly Asn Ile Ser Phe Lys Lys Glu Arg Asn Thr Asp 
         355                360                365
Gln Ala Ser Met Pro Glu Asn Thr Val Ala Gln Lys Leu Cys His Leu 
     370                375                380
Leu Gly Met Asn Val Met Glu Phe Thr Arg Ala Ile Leu Thr Pro Arg 
 385                390                395                400
Ile Lys Val Gly Arg Asp Tyr Val Gln Lys Ala Gln Thr Lys Glu Gln 
                 405                410                415
Ala Asp Phe Ala Val Glu Ala Leu Ala Lys Ala Thr Tyr Glu Arg Leu 
             420                425                430
Phe Arg Trp Leu Val His Arg Ile Asn Lys Ala Leu Asp Arg Thr Lys 
         435                440                445
Arg Gln Gly Thr Ser Phe Ile Gly Ile Leu Asp Ile Ala Gly Phe Glu 
     450                455                460
Ile Phe Glu Leu Asn Ser Phe Glu Gln Leu Cys Ile Asn Tyr Thr Asn 
 465                470                475                480
Glu Lys Leu Gln Gln Leu Phe Asn His Thr Met Phe Ile Leu Glu Gln 
                 485                490                495
Glu Glu Tyr Gln Arg Glu Gly Ile Glu Trp Asn Phe Ile Asp Phe Gly 
             500                505                510
Leu Asp Leu Gln Pro Cys Ile Asp Leu Ile Glu Arg Pro Ala Asn Pro 
         515                520                525
Pro Gly Val Leu Ala Leu Leu Asp Glu Glu Cys Trp Phe Pro Lys Ala 
     530                535                540
Thr Asp Lys Thr Phe Val Glu Lys Leu Val Gln Glu Gln Gly Ser His 
 545                550                555                560
Ser Lys Phe Gln Lys Pro Arg Gln Leu Lys Asp Lys Ala Asp Phe Cys 
                 565                570                575
Ile Ile His Tyr Ala Gly Lys Val Asp Tyr Lys Ala Asp Glu Trp Leu 
             580                585                590
Met Lys Asn Met Asp Pro Leu Asn Asp Asn Val Ala Thr Leu Leu His 
         595                600                605
Gln Ser Ser Asp Arg Phe Val Ala Glu Leu Trp Lys Asp Val Asp Arg 
     610                615                620
Ile Val Gly Leu Asp Gln Val Thr Gly Met Thr Glu Thr Ala Phe Gly 
 625                630                635                640
Ser Ala Tyr Lys Thr Lys Lys Gly Met Phe Arg Asn Val Gly Gln Leu 
                 645                650                655
Tyr Lys Glu Ser Leu Thr Lys Leu Met Ala Thr Leu Arg Asn Thr Asn 
             660                665                670
Pro Asn Phe Val Arg Cys Ile Ile Pro Asn His Glu Lys Arg Ala Gly 
         675                680                685
Lys Leu Asp Pro His Leu Val Leu Asp Gln Leu Arg Cys Asn Gly Val 
     690                695                700
Leu Glu Gly Ile Arg Ile Cys Arg Gln Gly Phe Pro Asn Arg Ile Val 
 705                710                715                720
Phe Gln Glu Phe Arg Gln Arg Tyr Glu Ile Leu Thr Pro Asn Ala Ile 
                 725                730                735
Pro Lys Gly Phe Met Asp Gly Lys Gln Ala Cys Glu Arg Met Ile Arg 
             740                745                750
Ala Leu Glu Leu Asp Pro Asn Leu Tyr Arg Ile Gly Gln Ser Lys Ile 
         755                760                765
Phe Phe Arg Ala Gly Val Leu Ala His Leu Glu Glu Glu Arg Asp Leu 
     770                775                780
Lys Ile Thr Asp Ile Ile Ile Phe Phe Gln Ala Val Cys Arg Gly Tyr 
 785                790                795                800
Leu Ala Arg Lys Ala Phe Ala Lys Lys Gln Gln Gln Leu Ser Ala Leu 
                 805                810                815
Lys Val Leu Gln Arg Asn Cys Ala Ala Tyr Leu Lys Leu Arg His Trp 
             820                825                830
Gln Trp Trp Arg Val Phe Thr Lys Val Lys Pro Leu Leu Gln Val Thr 
         835                840                845
Arg Gln Glu Glu Glu Leu Gln Ala Lys Asp Glu Glu Leu Leu Lys Val 
     850                855                860
Lys Glu Lys Gln Thr Lys Val Glu Gly Glu Leu Glu Glu Met Glu Arg 
 865                870                875                880
Lys His Gln Gln Leu Leu Glu Glu Lys Asn Ile Leu Ala Glu Gln Leu 
                 885                890                895
Gln Ala Glu Thr Glu Leu Phe Ala Glu Ala Glu Glu Met Arg Ala Arg 
             900                905                910
Leu Ala Ala Lys Lys Gln Glu Leu Glu Glu Ile Leu His Asp Leu Glu 
         915                920                925
Ser Arg Val Glu Gly Glu Glu Glu Arg Asn Gln Ile Leu Gln Asn Glu 
     930                935                940
Lys Lys Lys Met Gln Ala His Ile Gln Asp Leu Glu Glu Gln Leu Asp 
 945                950                955                960
Glu Glu Glu Gly Ala Arg Gln Lys Leu Gln Leu Glu Lys Val Thr Ala 
                 965                970                975
Glu Ala Lys Ile Lys Lys Met Glu Glu Glu Val Leu Leu Leu Glu Asp 
             980                985                990
Gln Asn Ser Lys Phe Ile Lys Glu Lys Lys Leu Met Glu Asp Arg Ile 
         995                1000                1005
Ala Glu Cys Ser Ser Gln Leu Ala Glu Glu Glu Glu Lys Ala Lys Asn 
     1010                1015                1020
Leu Ala Lys Ile Arg Asn Lys Gln Glu Val Met Ile Ser Asp Leu Glu 
 1025                1030                1035                1040
Glu Arg Leu Lys Lys Glu Glu Lys Thr Arg Gln Glu Leu Glu Lys Ala 
                 1045                1050                1055
Lys Arg Lys Leu Asp Gly Glu Thr Thr Asp Leu Gln Asp Gln Ile Ala 
             1060                1065                1070
Glu Leu Gln Ala Gln Val Asp Glu Leu Lys Val Gln Leu Thr Lys Lys 
         1075                1080                1085
Glu Glu Glu Leu Gln Gly Ala Leu Ala Arg Gly Asp Asp Glu Thr Leu 
     1090                1095                1100
His Lys Asn Asn Ala Leu Lys Val Ala Arg Glu Leu Gln Ala Gln Ile 
 1105                1110                1115                1120
Ala Glu Leu Gln Glu Asp Phe Glu Ser Glu Lys Ala Ser Arg Asn Lys 
                 1125                1130                1135
Ala Glu Lys Gln Lys Arg Asp Leu Ser Glu Glu Leu Glu Ala Leu Lys 
             1140                1145                1150
Thr Glu Leu Glu Asp Thr Leu Asp Thr Thr Ala Ala Gln Gln Glu Leu 
         1155                1160                1165
Arg Thr Lys Arg Glu Gln Glu Val Ala Glu Leu Lys Lys Ala Leu Glu 
     1170                1175                1180
Asp Glu Thr Lys Asn His Glu Ala Gln Ile Gln Asp Met Arg Gln Arg 
 1185                1190                1195                1200
His Ala Thr Ala Leu Glu Glu Leu Ser Glu Gln Leu Glu Gln Ala Lys 
                 1205                1210                1215
Arg Phe Lys Ala Asn Leu Glu Lys Asn Lys Gln Gly Leu Glu Thr Asp 
             1220                1225                1230
Asn Lys Glu Leu Ala Cys Glu Val Lys Val Leu Gln Gln Val Lys Ala 
         1235                1240                1245
Glu Ser Glu His Lys Arg Lys Lys Leu Asp Ala Gln Val Gln Glu Leu 
     1250                1255                1260
His Ala Lys Val Ser Glu Gly Asp Arg Leu Arg Val Glu Leu Ala Glu 
 1265                1270                1275                1280
Lys Ala Asn Lys Leu Gln Asn Glu Leu Asp Asn Val Ser Thr Leu Leu 
                 1285                1290                1295
Glu Glu Ala Glu Lys Lys Gly Met Lys Phe Ala Lys Asp Ala Ala Gly 
             1300                1305                1310
Leu Glu Ser Gln Leu Gln Asp Thr Gln Glu Leu Leu Gln Glu Glu Thr 
         1315                1320                1325
Arg Gln Lys Leu Asn Leu Ser Ser Arg Ile Arg Gln Leu Glu Glu Glu 
     1330                1335                1340
Lys Asn Ser Leu Gln Glu Gln Gln Glu Glu Glu Glu Glu Ala Arg Lys 
 1345                1350                1355                1360
Asn Leu Glu Lys Gln Val Leu Ala Leu Gln Ser Gln Leu Ala Asp Thr 
                 1365                1370                1375
Lys Lys Lys Val Asp Asp Asp Leu Gly Thr Ile Glu Gly Leu Glu Glu 
             1380                1385                1390
Ala Lys Lys Lys Leu Leu Lys Asp Val Glu Ala Leu Ser Gln Arg Leu 
         1395                1400                1405
Glu Glu Lys Val Leu Ala Tyr Asp Lys Leu Glu Lys Thr Lys Asn Arg 
     1410                1415                1420
Leu Gln Gln Glu Leu Asp Asp Leu Thr Val Asp Leu Asp His Gln Arg 
 1425                1430                1435                1440
Gln Ile Val Ser Asn Leu Glu Lys Lys Gln Lys Lys Phe Asp Gln Leu 
                 1445                1450                1455
Leu Ala Glu Glu Lys Gly Ile Ser Ala Arg Tyr Ala Glu Glu Arg Asp 
             1460                1465                1470
Arg Ala Glu Ala Glu Ala Arg Glu Lys Glu Thr Lys Ala Leu Ser Leu 
         1475                1480                1485
Ala Arg Ala Leu Glu Glu Ala Leu Glu Ala Lys Glu Glu Phe Glu Arg 
     1490                1495                1500
Gln Asn Lys Gln Leu Arg Ala Asp Met Glu Asp Leu Met Ser Ser Lys 
 1505                1510                1515                1520
Asp Asp Val Gly Lys Asn Val His Glu Leu Glu Lys Ser Lys Arg Ala 
                 1525                1530                1535
Leu Glu Gln Gln Val Glu Glu Met Arg Thr Gln Leu Glu Glu Leu Glu 
             1540                1545                1550
Asp Glu Leu Gln Ala Thr Glu Asp Ala Lys Leu Arg Leu Glu Val Asn 
         1555                1560                1565
Met Gln Ala Met Lys Ala Gln Phe Glu Arg Asp Leu Gln Thr Arg Asp 
     1570                1575                1580
Glu Gln Asn Glu Glu Lys Lys Arg Leu Leu Leu Lys Gln Val Arg Glu 
 1585                1590                1595                1600
Leu Glu Ala Glu Leu Glu Asp Glu Arg Lys Gln Arg Ala Leu Ala Val 
                 1605                1610                1615
Ala Ser Lys Lys Lys Met Glu Ile Asp Leu Lys Asp Leu Glu Ala Gln 
             1620                1625                1630
Ile Glu Ala Ala Asn Lys Ala Arg Asp Glu Val Ile Lys Gln Leu Arg 
         1635                1640                1645
Lys Leu Gln Ala Gln Met Lys Asp Tyr Gln Arg Glu Leu Glu Glu Ala 
     1650                1655                1660
Arg Ala Ser Arg Asp Glu Ile Phe Ala Gln Ser Lys Glu Ser Glu Lys 
 1665                1670                1675                1680
Lys Leu Lys Ser Leu Glu Ala Glu Ile Leu Gln Leu Gln Glu Glu Leu 
                 1685                1690                1695
Ala Ser Ser Glu Arg Ala Arg Arg His Ala Glu Gln Glu Arg Asp Glu 
             1700                1705                1710
Leu Ala Asp Glu Ile Ala Asn Ser Ala Ser Gly Lys Ser Ala Leu Leu 
         1715                1720                1725
Asp Glu Lys Arg Arg Leu Glu Ala Arg Ile Ala Gln Leu Glu Glu Glu 
     1730                1735                1740
Leu Glu Glu Glu Gln Ser Asn Met Glu Leu Leu Asn Asp Arg Phe Arg 
 1745                1750                1755                1760
Lys Thr Thr Leu Gln Val Asp Thr Leu Asn Thr Glu Leu Ala Ala Glu 
                 1765                1770                1775
Arg Ser Ala Ala Gln Lys Ser Asp Asn Ala Arg Gln Gln Leu Glu Arg 
             1780                1785                1790
Gln Asn Lys Glu Leu Lys Ala Lys Leu Gln Glu Leu Glu Gly Ala Val 
         1795                1800                1805
Lys Ser Lys Phe Lys Ala Thr Ile Ser Ala Leu Glu Ala Lys Ile Gly 
     1810                1815                1820
Gln Leu Glu Glu Gln Leu Glu Gln Glu Ala Lys Glu Arg Ala Ala Ala 
 1825                1830                1835                1840
Asn Lys Leu Val Arg Arg Thr Glu Lys Lys Leu Lys Glu Ile Phe Met 
                 1845                1850                1855
Gln Val Glu Asp Glu Arg Arg His Ala Asp Gln Tyr Lys Glu Gln Met 
             1860                1865                1870
Glu Lys Ala Asn Ala Arg Met Lys Gln Leu Lys Arg Gln Leu Glu Glu 
         1875                1880                1885
Ala Glu Glu Glu Ala Thr Arg Ala Asn Ala Ser Arg Arg Lys Leu Gln 
     1890                1895                1900
Arg Glu Leu Asp Asp Ala Thr Glu Ala Asn Glu Gly Leu Ser Arg Glu 
 1905                1910                1915                1920
Val Ser Thr Leu Lys Asn Arg Leu Arg Arg Gly Gly Pro Ile Ser Phe 
                 1925                1930                1935
Ser Ser Ser Arg Ser Gly Arg Arg Gln Leu His Ile Glu Gly Ala Ser 
             1940                1945                1950
Leu Glu Leu Ser Asp Asp Asp Thr Glu Ser Lys Thr Ser Asp Val Asn 
         1955                1960                1965
Glu Thr Gln Pro Pro Gln Ser Glu 
     1970                1975



<210> 9459
<211> 3037
<212> DNA
<213> Homo sapiens
<308> BC000280
<400> 9459

agaacaagc  gctccgagc  gacatggaa  acctcatga  ctccaaaga  gatgtggga  60
aaaacgttc  cgaacttga  aaatccaaa  gggccctag  gcagcaggt  gaggaaatg  120
ggacccagc  ggaggagct  gaagacgaa  tccaggcca  ggaagatgc  aagcttcgt  180
tggaggtca  catgcaggc  atgaaggcg  agttcgaga  agacctgca  accagggat  240
agcagaatg  agagaagaa  cggctgctg  tcaaacagg  gcgggagct  gaggcggag  300
tggaggatg  gaggaaaca  cgggcgctt  ctgtagctt  aaagaaaaa  atggagata  360
acctgaagg  cctcgaagc  caaatcgag  ctgcgaaca  agctcggga  gaggtgatt  420
agcagctcc  caagctcca  gctcagatg  aggattacc  acgtgaatt  gaagaagct  480
gtgcatcca  agatgagat  tttgctcaa  ccaaagaga  tgaaaagaa  ttgaagagt  540
tggaagcag  aatccttca  ttgcaggag  aacttgcct  atctgagcg  gcccgccga  600
acgccgagc  ggagagaga  gagctggcg  acgagatca  caacagcgc  tctggcaag  660
ccgcgctgc  ggatgagaa  cggcgtctg  aagctcgga  cgcacagct  gaggaggag  720
tggaagagg  gcagagcaa  atggagctg  tcaacgacc  cttccgcaa  accactcta  780
aggtggaca  actgaacgc  gagctagca  ccgagcgca  cgccgccca  aagagtgac  840
atgcacgcc  gcaactgga  cggcagaac  aggagctga  ggccaagct  caggaactc  900
agggtgctg  caagtctaa  ttcaaggcc  ccatctcag  cctggaggc  aagattggg  960
agctggagg  gcagcttga  caggaagcc  aggaacgag  agccgccaa  aaattagtc  1020
gtcgcactg  gaagaagct  aaagaaatc  tcatgcagg  tgaggatga  cgtcgacac  1080
cggaccagt  taaagagca  atggagaag  ccaacgctc  gatgaagca  cttaaacgc  1140
agctggagg  agcagaaga  gaagcgacg  gtgccaacg  atctcggcg  aaactccag  1200
gggaactgg  tgatgccac  gaggccaac  agggcctga  ccgcgaggt  agcaccctg  1260
agaaccggc  gaggcgggg  ggccccatc  gcttctctt  cagccgatc  ggccggcgc  1320
agctgcacc  tgaaggagc  tccctggag  tctccgacg  tgacacaga  agtaagacc  1380
gtgatgtca  cgagacgca  ccaccccag  cagagtaaa  ttgcaggaa  ccagaggag  1440
caatacagt  ggacagtta  gaatgcacc  ggggcctcc  gcagatttc  gaaattggc  1500
agctacggg  ttccttcct  aaagatcaa  tgtgtctta  ggctctcca  cctatgcat  1560
ctgtatcct  cttcagact  aggtacaat  gctcccctt  ttatataca  acacacaca  1620
gacacatat  ttaaacaga  tgtttcatc  ttgcatcta  tttccatat  gtcatcaag  1680
gaccatttt  taaaacatg  taagaccct  tttaaaaca  actccaggc  cttggttgc  1740
ggtcgctgg  ttattgggg  agcgccgtg  tcgtcactc  gtcgctctg  atgctctct  1800
tcatacaga  aggtaacct  gttctgtgt  cacgtggcc  ccgactcct  agccacatc  1860
agtctccta  accactgtg  actctaaac  gcacttgtc  ctctcattt  cttcaaata  1920
tgatcaatg  tatttcagt  agcaaactg  gaaaggggc  ttggaaaga  taggagggg  1980
gggctggat  ggaagcaac  cccatttgg  gttaccatg  ccatccccc  aggggggcc  2040
tgcccctcg  gtcgatggt  tcccgcatc  actcatgtg  actggcctt  gcgagggct  2100
gtctgtgca  agaagggat  gtggccaca  tgcagctga  gccccaggt  gcagccatg  2160
atcatgtag  cttccagat  gtctcccga  ccgcctggc  ctgccggcg  cctcctcac  2220
tcaggagca  gcagccgtg  acccctaag  cgagctggt  gaaggcccc  ccctgtcgc  2280
agccgggcc  tcatgctga  cttgcaaat  cagccgctg  tttgagccc  aaatgggaa  2340
attggtttt  tgtccgagg  ttgttccaa  tttgtcaat  aggtttatg  agcctccag  2400
acagatgcc  tcttcctga  tgttgacat  ccagtgggt  tgactcctt  atttttcct  2460
ctcccttcc  tttggacag  gttacagtg  acacttagc  tcctgtttt  ggttggtag  2520
taagcaaac  gacattacg  aaagtgcct  agacactac  gtactaaga  aatgttgaa  2580
atatcattc  cctctataa  aatttaatg  attcagttt  gactgtgct  catatcatg  2640
acctctcta  tcaaagtgg  attacagac  ttcagtgac  atgaatcag  gttaattct  2700
aatccttga  cctctgcaa  gtgcttgaa  acacaaacc  tttgggtta  aagctttaa  2760
atctattag  aagaatttg  cctgtgggt  tggaatctt  gattttccc  ctttatgaa  2820
tgtactggc  gttgaccac  agacacctg  ccgcaaata  cttttcttg  attcccata  2880
ttctagaca  tgatttttg  aagacaata  atttattca  tatagatat  tgcgcctgc  2940
ctgtttact  gaagaaaaa  gcacccgtg  agaataaag  gacctcaat  aacaagaat  3000
atcatgtga  aaaaaaaaa  aaaaaaaaa  aaaaaaa  3037



<210> 9460
<211> 1972
<212> PRT
<213> Homo sapiens
<308> P35749
<400> 9460

Met Ala Gln Lys Gly Gln Leu Ser Asp Asp Glu Lys Phe Leu Phe Val 
  1               5                  10                  15
Asp Lys Asn Phe Ile Asn Ser Pro Val Ala Gln Ala Asp Trp Ala Ala 
             20                  25                  30
Lys Arg Leu Val Trp Val Pro Ser Glu Lys Gln Gly Phe Glu Ala Ala 
         35                  40                  45
Ser Ile Lys Glu Glu Lys Gly Asp Glu Val Val Val Glu Leu Val Glu 
     50                  55                  60
Asn Gly Lys Lys Val Thr Val Gly Lys Asp Asp Ile Gln Lys Met Asn 
 65                  70                  75                  80
Pro Pro Lys Phe Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu 
                 85                  90                  95
Asn Glu Ala Ser Val Leu His Asn Leu Arg Glu Arg Tyr Phe Ser Gly 
             100                105                110
Leu Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val Val Asn Pro Tyr 
         115                120                125
Lys His Leu Pro Ile Tyr Ser Glu Lys Ile Val Asp Met Tyr Lys Gly 
     130                135                140
Lys Lys Arg His Glu Met Pro Pro His Ile Tyr Ala Ile Ala Asp Thr 
 145                150                155                160
Ala Tyr Arg Ser Met Leu Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys 
                 165                170                175
Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile 
             180                185                190
Gln Tyr Leu Ala Val Val Ala Ser Ser His Lys Gly Lys Lys Asp Thr 
         195                200                205
Ser Ile Thr Gly Glu Leu Glu Lys Gln Leu Leu Gln Ala Asn Pro Ile 
     210                215                220
Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Lys Asn Asp Asn Ser Ser 
 225                230                235                240
Arg Phe Gly Lys Phe Ile Arg Ile Asn Phe Asp Val Thr Gly Tyr Ile 
                 245                250                255
Val Gly Ala Asn Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg Ala Ile 
             260                265                270
Arg Gln Ala Arg Asp Glu Arg Thr Phe His Ile Phe Tyr Tyr Met Ile 
         275                280                285
Ala Gly Ala Lys Glu Lys Met Arg Ser Asp Leu Leu Leu Glu Gly Phe 
     290                295                300
Asn Asn Tyr Thr Phe Leu Ser Asn Gly Phe Val Pro Ile Pro Ala Ala 
 305                310                315                320
Gln Asp Asp Glu Met Phe Gln Glu Thr Val Glu Ala Met Ala Ile Met 
                 325                330                335
Gly Phe Ser Glu Glu Glu Gln Leu Ser Ile Leu Lys Val Val Ser Ser 
             340                345                350
Val Leu Gln Leu Gly Asn Ile Val Phe Lys Lys Glu Arg Asn Thr Asp 
         355                360                365
Gln Ala Ser Met Pro Asp Asn Thr Ala Ala Gln Lys Val Cys His Leu 
     370                375                380
Met Gly Ile Asn Val Thr Asp Phe Thr Arg Ser Ile Leu Thr Pro Arg 
 385                390                395                400
Ile Lys Val Gly Arg Asp Val Val Gln Lys Ala Gln Thr Lys Glu Gln 
                 405                410                415
Ala Asp Phe Ala Val Glu Ala Leu Ala Lys Ala Thr Tyr Glu Arg Leu 
             420                425                430
Phe Arg Trp Ile Leu Thr Arg Val Asn Lys Ala Leu Asp Lys Thr His 
         435                440                445
Arg Gln Gly Ala Ser Phe Leu Gly Ile Leu Asp Ile Ala Gly Phe Glu 
     450                455                460
Ile Phe Glu Val Asn Ser Phe Glu Gln Leu Cys Ile Asn Tyr Thr Asn 
 465                470                475                480
Glu Lys Leu Gln Gln Leu Phe Asn His Thr Met Phe Ile Leu Glu Gln 
                 485                490                495
Glu Glu Tyr Gln Arg Glu Gly Ile Glu Trp Asn Phe Ile Asp Phe Gly 
             500                505                510
Leu Asp Leu Gln Pro Cys Ile Glu Leu Ile Glu Arg Pro Asn Asn Pro 
         515                520                525
Pro Gly Val Leu Ala Leu Leu Asp Glu Glu Cys Trp Phe Pro Lys Ala 
     530                535                540
Thr Asp Lys Ser Phe Val Glu Lys Leu Cys Thr Glu Gln Gly Ser His 
 545                550                555                560
Pro Lys Phe Gln Lys Pro Lys Gln Leu Lys Asp Lys Thr Glu Phe Ser 
                 565                570                575
Ile Ile His Tyr Ala Gly Lys Val Asp Tyr Asn Ala Ser Ala Trp Leu 
             580                585                590
Thr Lys Asn Met Asp Pro Leu Asn Asp Asn Val Thr Ser Leu Leu Asn 
         595                600                605
Ala Ser Ser Asp Lys Phe Val Ala Asp Leu Trp Lys Asp Val Asp Arg 
     610                615                620
Ile Val Gly Leu Asp Gln Met Ala Lys Met Thr Glu Ser Ser Leu Pro 
 625                630                635                640
Ser Ala Ser Lys Thr Lys Lys Gly Met Phe Arg Thr Val Gly Gln Leu 
                 645                650                655
Tyr Lys Glu Gln Leu Gly Lys Leu Met Thr Thr Leu Arg Asn Thr Thr 
             660                665                670
Pro Asn Phe Val Arg Cys Ile Ile Pro Asn His Glu Lys Arg Ser Gly 
         675                680                685
Lys Leu Asp Ala Phe Leu Val Leu Glu Gln Leu Arg Cys Asn Gly Val 
     690                695                700
Leu Glu Gly Ile Arg Ile Cys Arg Gln Gly Phe Pro Asn Arg Ile Val 
 705                710                715                720
Phe Gln Glu Phe Arg Gln Arg Tyr Glu Ile Leu Ala Ala Asn Ala Ile 
                 725                730                735
Pro Lys Gly Phe Met Asp Gly Lys Gln Ala Cys Ile Leu Met Ile Lys 
             740                745                750
Ala Leu Glu Leu Asp Pro Asn Leu Tyr Arg Ile Gly Gln Ser Lys Ile 
         755                760                765
Phe Phe Arg Thr Gly Val Leu Ala His Leu Glu Glu Glu Arg Asp Leu 
     770                775                780
Lys Ile Thr Asp Val Ile Met Ala Phe Gln Ala Met Cys Arg Gly Tyr 
 785                790                795                800
Leu Ala Arg Lys Ala Phe Ala Lys Arg Gln Gln Gln Leu Thr Ala Met 
                 805                810                815
Lys Val Ile Gln Arg Asn Cys Ala Ala Tyr Leu Lys Leu Arg Asn Trp 
             820                825                830
Gln Trp Trp Arg Leu Phe Thr Lys Val Lys Pro Leu Leu Gln Val Thr 
         835                840                845
Arg Gln Glu Glu Glu Met Gln Ala Lys Glu Asp Glu Leu Gln Lys Thr 
     850                855                860
Lys Glu Arg Gln Gln Lys Ala Glu Asn Glu Leu Lys Glu Leu Glu Gln 
 865                870                875                880
Lys His Ser Gln Leu Thr Glu Glu Lys Asn Leu Leu Gln Glu Gln Leu 
                 885                890                895
Gln Ala Glu Thr Glu Leu Tyr Ala Glu Ala Glu Glu Met Arg Val Arg 
             900                905                910
Leu Ala Ala Lys Lys Gln Glu Leu Glu Glu Ile Leu His Glu Met Glu 
         915                920                925
Ala Arg Leu Glu Glu Glu Glu Asp Arg Gly Gln Gln Leu Gln Ala Glu 
     930                935                940
Arg Lys Lys Met Ala Gln Gln Met Leu Asp Leu Glu Glu Gln Leu Glu 
 945                950                955                960
Glu Glu Glu Ala Ala Arg Gln Lys Leu Gln Leu Glu Lys Val Thr Ala 
                 965                970                975
Glu Ala Lys Ile Lys Lys Leu Glu Asp Glu Ile Leu Val Met Asp Asp 
             980                985                990
Gln Asn Asn Lys Leu Ser Lys Glu Arg Lys Leu Leu Glu Glu Arg Ile 
         995                1000                1005
Ser Asp Leu Thr Thr Asn Leu Ala Glu Glu Glu Glu Lys Ala Lys Asn 
     1010                1015                1020
Leu Thr Lys Leu Lys Asn Lys His Glu Ser Met Ile Ser Glu Leu Glu 
 1025                1030                1035                1040
Val Arg Leu Lys Lys Glu Glu Lys Ser Arg Gln Glu Leu Glu Lys Leu 
                 1045                1050                1055
Lys Arg Lys Leu Glu Gly Asp Ala Ser Asp Phe His Glu Gln Ile Ala 
             1060                1065                1070
Asp Leu Gln Ala Gln Ile Ala Glu Leu Lys Met Gln Leu Ala Lys Lys 
         1075                1080                1085
Glu Glu Glu Leu Gln Ala Ala Leu Ala Arg Leu Asp Asp Glu Ile Ala 
     1090                1095                1100
Gln Lys Asn Asn Ala Leu Lys Lys Ile Arg Glu Leu Glu Gly His Ile 
 1105                1110                1115                1120
Ser Asp Leu Gln Glu Asp Leu Asp Ser Glu Arg Ala Ala Arg Asn Lys 
                 1125                1130                1135
Ala Glu Lys Gln Lys Arg Asp Leu Gly Glu Glu Leu Glu Ala Leu Lys 
             1140                1145                1150
Thr Glu Leu Glu Asp Thr Leu Asp Ser Thr Ala Thr Gln Gln Glu Leu 
         1155                1160                1165
Arg Ala Lys Arg Glu Gln Glu Val Thr Val Leu Lys Lys Ala Leu Asp 
     1170                1175                1180
Glu Glu Thr Arg Ser His Glu Ala Gln Val Gln Glu Met Arg Gln Lys 
 1185                1190                1195                1200
His Ala Gln Ala Val Glu Glu Leu Thr Glu Gln Leu Glu Gln Phe Lys 
                 1205                1210                1215
Arg Ala Lys Ala Asn Leu Asp Lys Asn Lys Gln Thr Leu Glu Lys Glu 
             1220                1225                1230
Asn Ala Asp Leu Ala Gly Glu Leu Arg Val Leu Gly Gln Ala Lys Gln 
         1235                1240                1245
Glu Val Glu His Lys Lys Lys Lys Leu Glu Ala Gln Val Gln Glu Leu 
     1250                1255                1260
Gln Ser Lys Cys Ser Asp Gly Glu Arg Ala Arg Ala Glu Leu Asn Asp 
 1265                1270                1275                1280
Lys Val His Lys Leu Gln Asn Glu Val Glu Ser Val Thr Gly Met Leu 
                 1285                1290                1295
Asn Glu Ala Glu Gly Lys Ala Ile Lys Leu Ala Lys Asp Val Ala Ser 
             1300                1305                1310
Leu Ser Ser Gln Leu Gln Asp Thr Gln Glu Leu Leu Gln Glu Glu Thr 
         1315                1320                1325
Arg Gln Lys Leu Asn Val Ser Thr Lys Leu Arg Gln Leu Glu Glu Glu 
     1330                1335                1340
Arg Asn Ser Leu Gln Asp Gln Leu Asp Glu Glu Met Glu Ala Lys Gln 
 1345                1350                1355                1360
Asn Leu Glu Arg His Ile Ser Thr Leu Asn Ile Gln Leu Ser Asp Ser 
                 1365                1370                1375
Lys Lys Lys Leu Gln Asp Phe Ala Ser Thr Val Glu Ala Leu Glu Glu 
             1380                1385                1390
Gly Lys Lys Arg Phe Gln Lys Glu Ile Glu Asn Leu Thr Gln Gln Tyr 
         1395                1400                1405
Glu Glu Lys Ala Ala Ala Tyr Asp Lys Leu Glu Lys Thr Lys Asn Arg 
     1410                1415                1420
Leu Gln Gln Glu Leu Asp Asp Leu Val Val Asp Leu Asp Asn Gln Arg 
 1425                1430                1435                1440
Gln Leu Val Ser Asn Leu Glu Lys Lys Gln Arg Lys Phe Asp Gln Leu 
                 1445                1450                1455
Leu Ala Glu Glu Lys Asn Ile Ser Ser Lys Tyr Ala Asp Glu Arg Asp 
             1460                1465                1470
Arg Ala Glu Ala Glu Ala Arg Glu Lys Glu Thr Lys Ala Leu Ser Leu 
         1475                1480                1485
Ala Arg Ala Leu Glu Glu Ala Leu Glu Ala Lys Glu Glu Leu Glu Arg 
     1490                1495                1500
Thr Asn Lys Met Leu Lys Ala Glu Met Glu Asp Leu Val Ser Ser Lys 
 1505                1510                1515                1520
Asp Asp Val Gly Lys Asn Val His Glu Leu Glu Lys Ser Lys Arg Ala 
                 1525                1530                1535
Leu Glu Thr Gln Met Glu Glu Met Lys Thr Gln Leu Glu Glu Leu Glu 
             1540                1545                1550
Asp Glu Leu Gln Ala Thr Glu Asp Ala Lys Leu Arg Leu Glu Val Asn 
         1555                1560                1565
Met Gln Ala Leu Lys Gly Gln Phe Glu Arg Asp Leu Gln Ala Arg Asp 
     1570                1575                1580
Glu Gln Asn Glu Glu Lys Arg Arg Gln Leu Gln Arg Gln Leu His Glu 
 1585                1590                1595                1600
Tyr Glu Thr Glu Leu Glu Asp Glu Arg Lys Gln Arg Ala Leu Ala Ala 
                 1605                1610                1615
Ala Ala Lys Lys Lys Leu Glu Gly Asp Leu Lys Asp Leu Glu Leu Gln 
             1620                1625                1630
Ala Asp Ser Ala Ile Lys Gly Arg Glu Glu Ala Ile Lys Gln Leu Arg 
         1635                1640                1645
Lys Leu Gln Ala Gln Met Lys Asp Phe Gln Arg Glu Leu Glu Asp Ala 
     1650                1655                1660
Arg Ala Ser Arg Asp Glu Ile Phe Ala Thr Ala Lys Glu Asn Glu Lys 
 1665                1670                1675                1680
Lys Ala Lys Ser Leu Glu Ala Asp Leu Met Gln Leu Gln Glu Asp Leu 
                 1685                1690                1695
Ala Ala Ala Glu Arg Ala Arg Lys Gln Ala Asp Leu Glu Lys Glu Glu 
             1700                1705                1710
Leu Ala Glu Glu Leu Ala Ser Ser Leu Ser Gly Arg Asn Ala Leu Gln 
         1715                1720                1725
Asp Glu Lys Arg Arg Leu Glu Ala Arg Ile Ala Gln Leu Glu Glu Glu 
     1730                1735                1740
Leu Glu Glu Glu Gln Gly Asn Met Glu Ala Met Ser Asp Arg Val Arg 
 1745                1750                1755                1760
Lys Ala Thr Gln Gln Ala Glu Gln Leu Ser Asn Glu Leu Ala Thr Glu 
                 1765                1770                1775
Arg Ser Thr Ala Gln Lys Asn Glu Ser Ala Arg Gln Gln Leu Glu Arg 
             1780                1785                1790
Gln Asn Lys Glu Leu Arg Ser Lys Leu His Glu Met Glu Gly Ala Val 
         1795                1800                1805
Lys Ser Lys Phe Lys Ser Thr Ile Ala Ala Leu Glu Ala Lys Ile Ala 
     1810                1815                1820
Gln Leu Glu Glu Gln Val Glu Gln Glu Ala Arg Glu Lys Gln Ala Ala 
 1825                1830                1835                1840
Thr Lys Ser Leu Lys Gln Lys Asp Lys Lys Leu Lys Glu Ile Leu Leu 
                 1845                1850                1855
Gln Val Glu Asp Glu Arg Lys Met Ala Glu Gln Tyr Lys Glu Gln Ala 
             1860                1865                1870
Glu Lys Gly Asn Ala Arg Val Lys Gln Leu Lys Arg Gln Leu Glu Glu 
         1875                1880                1885
Ala Glu Glu Glu Ser Gln Arg Ile Asn Ala Asn Arg Arg Lys Leu Gln 
     1890                1895                1900
Arg Glu Leu Asp Glu Ala Thr Glu Ser Asn Glu Ala Met Gly Arg Glu 
 1905                1910                1915                1920
Val Asn Ala Leu Lys Ser Lys Leu Arg Arg Gly Asn Glu Thr Ser Phe 
                 1925                1930                1935
Val Pro Ser Arg Arg Ser Gly Gly Arg Arg Val Ile Glu Asn Ala Asp 
             1940                1945                1950
Gly Ser Glu Glu Glu Thr Asp Thr Arg Asp Ala Asp Phe Asn Gly Thr 
         1955                1960                1965
Lys Ala Ser Glu 
     1970



<210> 9461
<211> 2348
<212> DNA
<213> Rattus norvegicus
<308> X16262
<400> 9461

ctggatgag  agatggaag  taagcaaaa  cttgagcgc  atgtctcca  cttgaacat  60
cagctctca  actctaaga  gaagctgca  gaccttgca  gcactattg  ggtcatgga  120
gaggggaag  agaggttgc  gaaagagat  gagggtctc  gccagcagt  tgaggagaa  180
gccgctgcc  atgacaaac  ggagaaaac  aagaacagg  ttcagcagg  gctagatga  240
ttggtcgtg  acttggaca  ccagcggca  ctggtatcc  atctggaaa  gaagcagaa  300
aaattcgat  agttgttag  tgaggaaaa  aacatctcc  ccaagtatg  ggatgagag  360
gaccgagct  aagcagagg  cagggaaaa  gaaacgaag  ctttgtctc  ggcccgggc  420
ctggaggaa  ccctggaag  caaagagga  ctggaaagg  ccaacaaga  gctcaaggc  480
gagatggaa  acctggtca  ctccaagga  gacgtgggc  agaatgtgc  cgagctgga  540
aagtccaaa  gagccctgg  gacccagat  gaagagatg  gaactcagc  agaggagct  600
gaggacgag  tgcaggcca  tgaagacgc  aagctgcgg  tggaggtca  catgcaggc  660
ctcaagggc  agtttgaac  agatctcca  gctcgggat  agcagaatg  ggagaagag  720
aggcagcta  agcggcagc  gcatgagta  gagacagaa  tggaagatg  acggaagca  780
agggctctg  cggcagcag  caagaagaa  ctggaaggg  atctgaaag  cctggaact  840
caggctgac  cagccgtca  agggaggga  gaagccatc  agcagcttc  aaaactgca  900
gctcagatg  aggacttcc  aagagagct  gatgatgcc  gtgcctcca  agatgagat  960
tttgccacc  caaaagaga  tgagaagaa  gccaagagt  tggaggcag  gctcatgca  1020
ctccaggag  acctggcag  agctgagag  gctcgcaag  aagctgacc  ggagaagga  1080
gagctggct  aggagctgg  tagcagctt  tcaggaagg  atacactgc  ggatgagaa  1140
cgccgcctg  aggcaagga  cgcccagct  gaggaggag  tggaggaag  gcagggcaa  1200
atggaggcc  tgagtgaca  agtccgcaa  gccacattg  aggctgagc  actgagcaa  1260
gagctggtc  ctgagcgca  tgcagctca  aagaatgag  gtgcacggc  acagctgga  1320
cgccagaac  aggaactcc  aagcaagtt  caggaggta  aaggtgctg  caaagccaa  1380
cttaagtcc  ctgttgcgg  actagaggc  aagattgtg  agctggagg  gcagattga  1440
caagaggcc  gagaaaaac  ggcagccac  aagttgctg  agcaaaagg  caagaagct  1500
aaggaggtc  tactgcagg  ggaggatga  cgcaagatg  tggagcagt  caaggagca  1560
gcagagaaa  gaaacacca  ggtcaagca  ctcaagagg  agctggaag  ggccgagga  1620
gaatcccag  gcatcaatg  caaccgcag  aagctgcag  gggagctgg  tgaggccac  1680
gagagcaat  aggccatgg  ccgtgaggt  aatgccctc  agagcaaac  caggagagg  1740
aacgaggct  catttgttc  ttccagaag  gctggaggc  gtagagtta  tgaaaacac  1800
gatggttct  aagaagaaa  ggatgctcg  gactcagac  tcaatggaa  caaagccag  1860
gaataaatt  agttggaca  tatgtcagg  aaaacaaaa  accaaatga  agcaaagcc  1920
agcaggctg  ttagcattt  tctccattc  ttctcaagt  atagacatt  ccccacctc  1980
caccaggag  caaccacag  cctgcacaa  ggatgtgaa  ttaagtttt  aaatgtgct  2040
ccagagaaa  tccagatag  tgcaggtcg  gagctgcag  cgccagtgc  tttgtttac  2100
tgaaatgga  cgttacgtg  atgggtgcc  cagcgccaa  ccgctccca  ccatcaact  2160
cctgacctt  cagtttggg  ggaaaacct  tttgaaaat  cccctccct  tcctgcctg  2220
acacctcag  cacacagtt  actaagacc  agtgacttt  tcagtcatc  gaattaagg  2280
agagcagag  gagcgcacc  ccttatttg  acccacgga  actttcacg  ataaaaggt  2340
ttaagtca  2348



<210> 9462
<211> 1976
<212> PRT
<213> Rattus norvegicus
<308> Q9JLT0
<400> 9462

Met Ala Gln Arg Thr Gly Leu Glu Asp Pro Glu Arg Tyr Leu Phe Val 
  1               5                  10                  15
Asp Arg Ala Val Ile Tyr Asn Pro Ala Thr Gln Ala Asp Trp Thr Ala 
             20                  25                  30
Lys Lys Leu Val Trp Ile Pro Ser Glu Arg His Gly Phe Glu Ala Ala 
         35                  40                  45
Ser Ile Lys Glu Glu Arg Gly Asp Glu Val Met Val Glu Leu Ala Glu 
     50                  55                  60
Asn Gly Lys Lys Ala Met Val Asn Lys Asp Asp Ile Gln Lys Met Asn 
 65                  70                  75                  80
Pro Pro Lys Phe Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu 
                 85                  90                  95
Asn Glu Ala Ser Val Leu His Asn Leu Lys Asp Arg Tyr Tyr Ser Gly 
             100                105                110
Leu Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val Ile Asn Pro Tyr 
         115                120                125
Lys Asn Leu Pro Ile Tyr Ser Glu Asn Ile Ile Glu Met Tyr Arg Gly 
     130                135                140
Lys Lys Arg His Glu Lys Pro Pro His Ile Tyr Ala Ile Ser Glu Ser 
 145                150                155                160
Ala Tyr Arg Cys Met Leu Gln Asp Arg Lys Asp Gln Ser Ile Leu Cys 
                 165                170                175
Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile 
             180                185                190
Gln Tyr Leu Ala His Val Ala Ser Ser His Lys Gly Arg Lys Asp His 
         195                200                205
Asn Ile Pro Gly Glu Leu Glu Arg Gln Leu Leu Gln Ala Asn Pro Ile 
     210                215                220
Leu Glu Ser Phe Gly Asn Ala Lys Thr Val Lys Asn Asp Asn Ser Ser 
 225                230                235                240
Arg Phe Gly Lys Phe Ile Arg Ile Asn Phe Asp Val Thr Gly Tyr Ile 
                 245                250                255
Val Gly Ala Asn Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg Ala Val 
             260                265                270
Arg Gln Ala Lys Asp Glu Arg Thr Phe His Ile Phe Tyr Gln Leu Leu 
         275                280                285
Ser Gly Ala Gly Glu His Leu Lys Ser Asp Leu Leu Leu Glu Gly Phe 
     290                295                300
Asn Asn Tyr Arg Phe Leu Ser Asn Gly Tyr Ile Pro Ile Pro Gly Gln 
 305                310                315                320
Gln Asp Lys Asp Asn Phe Gln Glu Thr Met Glu Ala Met His Ile Met 
                 325                330                335
Gly Phe Ser His Glu Glu Ile Leu Ser Met Leu Lys Val Val Ser Ser 
             340                345                350
Val Leu Gln Phe Gly Asn Ile Ser Phe Lys Lys Glu Arg Asn Thr Asp 
         355                360                365
Gln Ala Ser Met Pro Glu Asn Thr Val Ala Gln Lys Leu Cys His Leu 
     370                375                380
Leu Gly Met Asn Val Met Glu Phe Thr Arg Ala Ile Leu Thr Pro Arg 
 385                390                395                400
Ile Lys Val Gly Arg Asp Tyr Val Gln Lys Ala Gln Thr Lys Glu Gln 
                 405                410                415
Ala Asp Phe Ala Val Glu Ala Leu Ala Lys Ala Thr Tyr Glu Arg Leu 
             420                425                430
Phe Arg Trp Leu Val His Arg Ile Asn Lys Ala Leu Asp Arg Thr Lys 
         435                440                445
Arg Gln Gly Thr Ser Phe Ile Gly Ile Leu Asp Ile Ala Gly Phe Glu 
     450                455                460
Ile Phe Glu Leu Asn Ser Phe Glu Gln Leu Cys Ile Asn Tyr Thr Asn 
 465                470                475                480
Glu Lys Leu Gln Gln Leu Phe Asn His Thr Met Phe Ile Leu Glu Gln 
                 485                490                495
Glu Glu Tyr Gln Arg Glu Gly Ile Glu Trp Asn Phe Ile Asp Phe Gly 
             500                505                510
Leu Asp Leu Gln Pro Cys Ile Asp Leu Ile Glu Arg Pro Ala Asn Pro 
         515                520                525
Pro Gly Val Leu Ala Leu Leu Asp Glu Glu Cys Trp Phe Pro Lys Ala 
     530                535                540
Thr Asp Lys Thr Phe Val Glu Lys Leu Val Gln Glu Gln Gly Ser His 
 545                550                555                560
Ser Lys Phe Gln Lys Pro Arg Gln Leu Lys Asp Lys Ala Asp Phe Cys 
                 565                570                575
Ile Ile His Tyr Ala Gly Lys Val Asp Tyr Lys Ala Asp Glu Trp Leu 
             580                585                590
Met Lys Asn Met Asp Pro Leu Asn Asp Asn Val Ala Thr Leu Leu His 
         595                600                605
Gln Ser Ser Asp Arg Phe Val Ala Glu Leu Trp Lys Asp Val Asp Arg 
     610                615                620
Ile Val Gly Leu Asp Gln Val Thr Gly Met Thr Glu Thr Ala Phe Gly 
 625                630                635                640
Ser Ala Tyr Lys Thr Lys Lys Gly Met Phe Arg Asn Val Gly Gln Leu 
                 645                650                655
Tyr Lys Glu Ser Leu Thr Lys Leu Met Ala Thr Leu Arg Asn Thr Asn 
             660                665                670
Pro Asn Phe Val Arg Cys Ile Ile Pro Asn His Glu Lys Arg Ala Gly 
         675                680                685
Lys Leu Asp Pro His Leu Val Leu Asp Gln Leu Arg Cys Asn Gly Val 
     690                695                700
Leu Glu Gly Ile Arg Ile Cys Arg Gln Gly Phe Pro Asn Arg Ile Val 
 705                710                715                720
Phe Gln Glu Phe Arg Gln Arg Tyr Glu Ile Leu Thr Pro Asn Ala Ile 
                 725                730                735
Pro Lys Gly Phe Met Asp Gly Lys Gln Ala Cys Glu Arg Met Ile Arg 
             740                745                750
Ala Leu Glu Leu Asp Pro Asn Leu Tyr Arg Ile Gly Gln Ser Lys Ile 
         755                760                765
Phe Phe Arg Ala Gly Val Leu Ala His Leu Glu Glu Glu Arg Asp Leu 
     770                775                780
Lys Ile Thr Asp Ile Ile Ile Phe Phe Gln Ala Val Cys Arg Gly Tyr 
 785                790                795                800
Leu Ala Arg Lys Ala Phe Ala Lys Lys Gln Gln Gln Leu Ser Ala Leu 
                 805                810                815
Lys Val Leu Gln Arg Asn Cys Ala Ala Tyr Leu Lys Leu Arg His Trp 
             820                825                830
Gln Trp Trp Arg Val Phe Thr Lys Val Lys Pro Leu Leu Gln Val Thr 
         835                840                845
Arg Gln Glu Glu Glu Leu Gln Ala Lys Asp Glu Glu Leu Leu Lys Val 
     850                855                860
Lys Glu Lys Gln Thr Lys Val Glu Gly Glu Leu Glu Glu Met Glu Arg 
 865                870                875                880
Lys His Gln Gln Leu Leu Glu Glu Lys Asn Ile Leu Ala Glu Gln Leu 
                 885                890                895
Gln Ala Glu Thr Glu Leu Phe Ala Glu Ala Glu Glu Met Arg Ala Arg 
             900                905                910
Leu Ala Ala Lys Lys Gln Glu Leu Glu Glu Ile Leu His Asp Leu Glu 
         915                920                925
Ser Arg Val Glu Gly Glu Glu Glu Arg Asn Gln Ile Leu Gln Asn Glu 
     930                935                940
Lys Lys Lys Met Gln Ala His Ile Gln Asp Leu Glu Glu Gln Leu Asp 
 945                950                955                960
Glu Glu Glu Gly Ala Arg Gln Lys Leu Gln Leu Glu Lys Val Thr Ala 
                 965                970                975
Glu Ala Lys Ile Lys Lys Met Glu Glu Glu Val Leu Leu Leu Glu Asp 
             980                985                990
Gln Asn Ser Lys Phe Ile Lys Glu Lys Lys Leu Met Glu Asp Arg Ile 
         995                1000                1005
Ala Glu Cys Ser Ser Gln Leu Ala Glu Glu Glu Glu Lys Ala Lys Asn 
     1010                1015                1020
Leu Ala Lys Ile Arg Asn Lys Gln Glu Val Met Ile Ser Asp Leu Glu 
 1025                1030                1035                1040
Glu Arg Leu Lys Lys Glu Glu Lys Thr Arg Gln Glu Leu Glu Lys Ala 
                 1045                1050                1055
Lys Arg Lys Leu Asp Gly Glu Thr Thr Asp Leu Gln Asp Gln Ile Ala 
             1060                1065                1070
Glu Leu Gln Ala Gln Val Asp Glu Leu Lys Val Gln Leu Thr Lys Lys 
         1075                1080                1085
Glu Glu Glu Leu Gln Gly Ala Leu Ala Arg Gly Asp Asp Glu Thr Leu 
     1090                1095                1100
His Lys Asn Asn Ala Leu Lys Val Ala Arg Glu Leu Gln Ala Gln Ile 
 1105                1110                1115                1120
Ala Glu Leu Gln Glu Asp Phe Glu Ser Glu Lys Ala Ser Arg Asn Lys 
                 1125                1130                1135
Ala Glu Lys Gln Lys Arg Asp Leu Ser Glu Glu Leu Glu Ala Leu Lys 
             1140                1145                1150
Thr Glu Leu Glu Asp Thr Leu Asp Thr Thr Ala Ala Gln Gln Glu Leu 
         1155                1160                1165
Arg Thr Lys Arg Glu Gln Glu Val Ala Glu Leu Lys Lys Ala Leu Glu 
     1170                1175                1180
Asp Glu Thr Lys Asn His Glu Ala Gln Ile Gln Asp Met Arg Gln Arg 
 1185                1190                1195                1200
His Ala Thr Ala Leu Glu Glu Leu Ser Glu Gln Leu Glu Gln Ala Lys 
                 1205                1210                1215
Arg Phe Lys Ala Asn Leu Glu Lys Asn Lys Gln Gly Leu Glu Thr Asp 
             1220                1225                1230
Asn Lys Glu Leu Ala Cys Glu Val Lys Val Leu Gln Gln Val Lys Ala 
         1235                1240                1245
Glu Ser Glu His Lys Arg Lys Lys Leu Asp Ala Gln Val Gln Glu Leu 
     1250                1255                1260
His Ala Lys Val Ser Glu Gly Asp Arg Leu Arg Val Glu Leu Ala Glu 
 1265                1270                1275                1280
Lys Ala Asn Lys Leu Gln Asn Glu Leu Asp Asn Val Ser Thr Leu Leu 
                 1285                1290                1295
Glu Glu Ala Glu Lys Lys Gly Met Lys Phe Ala Lys Asp Ala Ala Gly 
             1300                1305                1310
Leu Glu Ser Gln Leu Gln Asp Thr Gln Glu Leu Leu Gln Glu Glu Thr 
         1315                1320                1325
Arg Gln Lys Leu Asn Leu Ser Ser Arg Ile Arg Gln Leu Glu Glu Glu 
     1330                1335                1340
Lys Asn Ser Leu Gln Glu Gln Gln Glu Glu Glu Glu Glu Ala Arg Lys 
 1345                1350                1355                1360
Asn Leu Glu Lys Gln Val Leu Ala Leu Gln Ser Gln Leu Ala Asp Thr 
                 1365                1370                1375
Lys Lys Lys Val Asp Asp Asp Leu Gly Thr Ile Glu Gly Leu Glu Glu 
             1380                1385                1390
Ala Lys Lys Lys Leu Leu Lys Asp Val Glu Ala Leu Ser Gln Arg Leu 
         1395                1400                1405
Glu Glu Lys Val Leu Ala Tyr Asp Lys Leu Glu Lys Thr Lys Asn Arg 
     1410                1415                1420
Leu Gln Gln Glu Leu Asp Asp Leu Thr Val Asp Leu Asp His Gln Arg 
 1425                1430                1435                1440
Gln Ile Val Ser Asn Leu Glu Lys Lys Gln Lys Lys Phe Asp Gln Leu 
                 1445                1450                1455
Leu Ala Glu Glu Lys Gly Ile Ser Ala Arg Tyr Ala Glu Glu Arg Asp 
             1460                1465                1470
Arg Ala Glu Ala Glu Ala Arg Glu Lys Glu Thr Lys Ala Leu Ser Leu 
         1475                1480                1485
Ala Arg Ala Leu Glu Glu Ala Leu Glu Ala Lys Glu Glu Phe Glu Arg 
     1490                1495                1500
Gln Asn Lys Gln Leu Arg Ala Asp Met Glu Asp Leu Met Ser Ser Lys 
 1505                1510                1515                1520
Asp Asp Val Gly Lys Asn Val His Glu Leu Glu Lys Ser Lys Arg Ala 
                 1525                1530                1535
Leu Glu Gln Gln Val Glu Glu Met Arg Thr Gln Leu Glu Glu Leu Glu 
             1540                1545                1550
Asp Glu Leu Gln Ala Thr Glu Asp Ala Lys Leu Arg Leu Glu Val Asn 
         1555                1560                1565
Met Gln Ala Met Lys Ala Gln Phe Glu Arg Asp Leu Gln Thr Arg Asp 
     1570                1575                1580
Glu Gln Asn Glu Glu Lys Lys Arg Leu Leu Leu Lys Gln Val Arg Glu 
 1585                1590                1595                1600
Leu Glu Ala Glu Leu Glu Asp Glu Arg Lys Gln Arg Ala Leu Ala Val 
                 1605                1610                1615
Ala Ser Lys Lys Lys Met Glu Ile Asp Leu Lys Asp Leu Glu Ala Gln 
             1620                1625                1630
Ile Glu Ala Ala Asn Lys Ala Arg Asp Glu Val Ile Lys Gln Leu Arg 
         1635                1640                1645
Lys Leu Gln Ala Gln Met Lys Asp Tyr Gln Arg Glu Leu Glu Glu Ala 
     1650                1655                1660
Arg Ala Ser Arg Asp Glu Ile Phe Ala Gln Ser Lys Glu Ser Glu Lys 
 1665                1670                1675                1680
Lys Leu Lys Ser Leu Glu Ala Glu Ile Leu Gln Leu Gln Glu Glu Leu 
                 1685                1690                1695
Ala Ser Ser Glu Arg Ala Arg Arg His Ala Glu Gln Glu Arg Asp Glu 
             1700                1705                1710
Leu Ala Asp Glu Ile Ala Asn Ser Ala Ser Gly Lys Ser Ala Leu Leu 
         1715                1720                1725
Asp Glu Lys Arg Arg Leu Glu Ala Arg Ile Ala Gln Leu Glu Glu Glu 
     1730                1735                1740
Leu Glu Glu Glu Gln Ser Asn Met Glu Leu Leu Asn Asp Arg Phe Arg 
 1745                1750                1755                1760
Lys Thr Thr Leu Gln Val Asp Thr Leu Asn Thr Glu Leu Ala Ala Glu 
                 1765                1770                1775
Arg Ser Ala Ala Gln Lys Ser Asp Asn Ala Arg Gln Gln Leu Glu Arg 
             1780                1785                1790
Gln Asn Lys Glu Leu Lys Ala Lys Leu Gln Glu Leu Glu Gly Ala Val 
         1795                1800                1805
Lys Ser Lys Phe Lys Ala Thr Ile Ser Ala Leu Glu Ala Lys Ile Gly 
     1810                1815                1820
Gln Leu Glu Glu Gln Leu Glu Gln Glu Ala Lys Glu Arg Ala Ala Ala 
 1825                1830                1835                1840
Asn Lys Leu Val Arg Arg Thr Glu Lys Lys Leu Lys Glu Ile Phe Met 
                 1845                1850                1855
Gln Val Glu Asp Glu Arg Arg His Ala Asp Gln Tyr Lys Glu Gln Met 
             1860                1865                1870
Glu Lys Ala Asn Ala Arg Met Lys Gln Leu Lys Arg Gln Leu Glu Glu 
         1875                1880                1885
Ala Glu Glu Glu Ala Thr Arg Ala Asn Ala Ser Arg Arg Lys Leu Gln 
     1890                1895                1900
Arg Glu Leu Asp Asp Ala Thr Glu Ala Asn Glu Gly Leu Ser Arg Glu 
 1905                1910                1915                1920
Val Ser Thr Leu Lys Asn Arg Leu Arg Arg Gly Gly Pro Ile Ser Phe 
                 1925                1930                1935
Ser Ser Ser Arg Ser Gly Arg Arg Gln Leu His Ile Glu Gly Ala Ser 
             1940                1945                1950
Leu Glu Leu Ser Asp Asp Asp Thr Glu Ser Lys Thr Ser Asp Val Asn 
         1955                1960                1965
Glu Thr Gln Pro Pro Gln Ser Glu 
     1970                1975



<210> 9463
<211> 3037
<212> DNA
<213> Homo sapiens
<308> BC000280
<400> 9463

agaacaagc  gctccgagc  gacatggaa  acctcatga  ctccaaaga  gatgtggga  60
aaaacgttc  cgaacttga  aaatccaaa  gggccctag  gcagcaggt  gaggaaatg  120
ggacccagc  ggaggagct  gaagacgaa  tccaggcca  ggaagatgc  aagcttcgt  180
tggaggtca  catgcaggc  atgaaggcg  agttcgaga  agacctgca  accagggat  240
agcagaatg  agagaagaa  cggctgctg  tcaaacagg  gcgggagct  gaggcggag  300
tggaggatg  gaggaaaca  cgggcgctt  ctgtagctt  aaagaaaaa  atggagata  360
acctgaagg  cctcgaagc  caaatcgag  ctgcgaaca  agctcggga  gaggtgatt  420
agcagctcc  caagctcca  gctcagatg  aggattacc  acgtgaatt  gaagaagct  480
gtgcatcca  agatgagat  tttgctcaa  ccaaagaga  tgaaaagaa  ttgaagagt  540
tggaagcag  aatccttca  ttgcaggag  aacttgcct  atctgagcg  gcccgccga  600
acgccgagc  ggagagaga  gagctggcg  acgagatca  caacagcgc  tctggcaag  660
ccgcgctgc  ggatgagaa  cggcgtctg  aagctcgga  cgcacagct  gaggaggag  720
tggaagagg  gcagagcaa  atggagctg  tcaacgacc  cttccgcaa  accactcta  780
aggtggaca  actgaacgc  gagctagca  ccgagcgca  cgccgccca  aagagtgac  840
atgcacgcc  gcaactgga  cggcagaac  aggagctga  ggccaagct  caggaactc  900
agggtgctg  caagtctaa  ttcaaggcc  ccatctcag  cctggaggc  aagattggg  960
agctggagg  gcagcttga  caggaagcc  aggaacgag  agccgccaa  aaattagtc  1020
gtcgcactg  gaagaagct  aaagaaatc  tcatgcagg  tgaggatga  cgtcgacac  1080
cggaccagt  taaagagca  atggagaag  ccaacgctc  gatgaagca  cttaaacgc  1140
agctggagg  agcagaaga  gaagcgacg  gtgccaacg  atctcggcg  aaactccag  1200
gggaactgg  tgatgccac  gaggccaac  agggcctga  ccgcgaggt  agcaccctg  1260
agaaccggc  gaggcgggg  ggccccatc  gcttctctt  cagccgatc  ggccggcgc  1320
agctgcacc  tgaaggagc  tccctggag  tctccgacg  tgacacaga  agtaagacc  1380
gtgatgtca  cgagacgca  ccaccccag  cagagtaaa  ttgcaggaa  ccagaggag  1440
caatacagt  ggacagtta  gaatgcacc  ggggcctcc  gcagatttc  gaaattggc  1500
agctacggg  ttccttcct  aaagatcaa  tgtgtctta  ggctctcca  cctatgcat  1560
ctgtatcct  cttcagact  aggtacaat  gctcccctt  ttatataca  acacacaca  1620
gacacatat  ttaaacaga  tgtttcatc  ttgcatcta  tttccatat  gtcatcaag  1680
gaccatttt  taaaacatg  taagaccct  tttaaaaca  actccaggc  cttggttgc  1740
ggtcgctgg  ttattgggg  agcgccgtg  tcgtcactc  gtcgctctg  atgctctct  1800
tcatacaga  aggtaacct  gttctgtgt  cacgtggcc  ccgactcct  agccacatc  1860
agtctccta  accactgtg  actctaaac  gcacttgtc  ctctcattt  cttcaaata  1920
tgatcaatg  tatttcagt  agcaaactg  gaaaggggc  ttggaaaga  taggagggg  1980
gggctggat  ggaagcaac  cccatttgg  gttaccatg  ccatccccc  aggggggcc  2040
tgcccctcg  gtcgatggt  tcccgcatc  actcatgtg  actggcctt  gcgagggct  2100
gtctgtgca  agaagggat  gtggccaca  tgcagctga  gccccaggt  gcagccatg  2160
atcatgtag  cttccagat  gtctcccga  ccgcctggc  ctgccggcg  cctcctcac  2220
tcaggagca  gcagccgtg  acccctaag  cgagctggt  gaaggcccc  ccctgtcgc  2280
agccgggcc  tcatgctga  cttgcaaat  cagccgctg  tttgagccc  aaatgggaa  2340
attggtttt  tgtccgagg  ttgttccaa  tttgtcaat  aggtttatg  agcctccag  2400
acagatgcc  tcttcctga  tgttgacat  ccagtgggt  tgactcctt  atttttcct  2460
ctcccttcc  tttggacag  gttacagtg  acacttagc  tcctgtttt  ggttggtag  2520
taagcaaac  gacattacg  aaagtgcct  agacactac  gtactaaga  aatgttgaa  2580
atatcattc  cctctataa  aatttaatg  attcagttt  gactgtgct  catatcatg  2640
acctctcta  tcaaagtgg  attacagac  ttcagtgac  atgaatcag  gttaattct  2700
aatccttga  cctctgcaa  gtgcttgaa  acacaaacc  tttgggtta  aagctttaa  2760
atctattag  aagaatttg  cctgtgggt  tggaatctt  gattttccc  ctttatgaa  2820
tgtactggc  gttgaccac  agacacctg  ccgcaaata  cttttcttg  attcccata  2880
ttctagaca  tgatttttg  aagacaata  atttattca  tatagatat  tgcgcctgc  2940
ctgtttact  gaagaaaaa  gcacccgtg  agaataaag  gacctcaat  aacaagaat  3000
atcatgtga  aaaaaaaaa  aaaaaaaaa  aaaaaaa  3037



<210> 9464
<211> 1972
<212> PRT
<213> Homo sapiens
<308> NP_002465
<400> 9464

Met Ala Gln Lys Gly Gln Leu Ser Asp Asp Glu Lys Phe Leu Phe Val 
  1               5                  10                  15
Asp Lys Asn Phe Ile Asn Ser Pro Val Ala Gln Ala Asp Trp Ala Ala 
             20                  25                  30
Lys Arg Leu Val Trp Val Pro Ser Glu Lys Gln Gly Phe Glu Ala Ala 
         35                  40                  45
Ser Ile Lys Glu Glu Lys Gly Asp Glu Val Val Val Glu Leu Val Glu 
     50                  55                  60
Asn Gly Lys Lys Val Thr Val Gly Lys Asp Asp Ile Gln Lys Met Asn 
 65                  70                  75                  80
Pro Pro Lys Phe Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu 
                 85                  90                  95
Asn Glu Ala Ser Val Leu His Asn Leu Arg Glu Arg Tyr Phe Ser Gly 
             100                105                110
Leu Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val Val Asn Pro Tyr 
         115                120                125
Lys His Leu Pro Ile Tyr Ser Glu Lys Ile Val Asp Met Tyr Lys Gly 
     130                135                140
Lys Lys Arg His Glu Met Pro Pro His Ile Tyr Ala Ile Ala Asp Thr 
 145                150                155                160
Ala Tyr Arg Ser Met Leu Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys 
                 165                170                175
Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile 
             180                185                190
Gln Tyr Leu Ala Val Val Ala Ser Ser His Lys Gly Lys Lys Asp Thr 
         195                200                205
Ser Ile Thr Gly Glu Leu Glu Lys Gln Leu Leu Gln Ala Asn Pro Ile 
     210                215                220
Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Lys Asn Asp Asn Ser Ser 
 225                230                235                240
Arg Phe Gly Lys Phe Ile Arg Ile Asn Phe Asp Val Thr Gly Tyr Ile 
                 245                250                255
Val Gly Ala Asn Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg Ala Ile 
             260                265                270
Arg Gln Ala Arg Asp Glu Arg Thr Phe His Ile Phe Tyr Tyr Met Ile 
         275                280                285
Ala Gly Ala Lys Glu Lys Met Arg Ser Asp Leu Leu Leu Glu Gly Phe 
     290                295                300
Asn Asn Tyr Thr Phe Leu Ser Asn Gly Phe Val Pro Ile Pro Ala Ala 
 305                310                315                320
Gln Asp Asp Glu Met Phe Gln Glu Thr Val Glu Ala Met Ala Ile Met 
                 325                330                335
Gly Phe Ser Glu Glu Glu Gln Leu Ser Ile Leu Lys Val Val Ser Ser 
             340                345                350
Val Leu Gln Leu Gly Asn Ile Val Phe Lys Lys Glu Arg Asn Thr Asp 
         355                360                365
Gln Ala Ser Met Pro Asp Asn Thr Ala Ala Gln Lys Val Cys His Leu 
     370                375                380
Met Gly Ile Asn Val Thr Asp Phe Thr Arg Ser Ile Leu Thr Pro Arg 
 385                390                395                400
Ile Lys Val Gly Arg Asp Val Val Gln Lys Ala Gln Thr Lys Glu Gln 
                 405                410                415
Ala Asp Phe Ala Val Glu Ala Leu Ala Lys Ala Thr Tyr Glu Arg Leu 
             420                425                430
Phe Arg Trp Ile Leu Thr Arg Val Asn Lys Ala Leu Asp Lys Thr His 
         435                440                445
Arg Gln Gly Ala Ser Phe Leu Gly Ile Leu Asp Ile Ala Gly Phe Glu 
     450                455                460
Ile Phe Glu Val Asn Ser Phe Glu Gln Leu Cys Ile Asn Tyr Thr Asn 
 465                470                475                480
Glu Lys Leu Gln Gln Leu Phe Asn His Thr Met Phe Ile Leu Glu Gln 
                 485                490                495
Glu Glu Tyr Gln Arg Glu Gly Ile Glu Trp Asn Phe Ile Asp Phe Gly 
             500                505                510
Leu Asp Leu Gln Pro Cys Ile Glu Leu Ile Glu Arg Pro Asn Asn Pro 
         515                520                525
Pro Gly Val Leu Ala Leu Leu Asp Glu Glu Cys Trp Phe Pro Lys Ala 
     530                535                540
Thr Asp Lys Ser Phe Val Glu Lys Leu Cys Thr Glu Gln Gly Ser His 
 545                550                555                560
Pro Lys Phe Gln Lys Pro Lys Gln Leu Lys Asp Lys Thr Glu Phe Ser 
                 565                570                575
Ile Ile His Tyr Ala Gly Lys Val Asp Tyr Asn Ala Ser Ala Trp Leu 
             580                585                590
Thr Lys Asn Met Asp Pro Leu Asn Asp Asn Val Thr Ser Leu Leu Asn 
         595                600                605
Ala Ser Ser Asp Lys Phe Val Ala Asp Leu Trp Lys Asp Val Asp Arg 
     610                615                620
Ile Val Gly Leu Asp Gln Met Ala Lys Met Thr Glu Ser Ser Leu Pro 
 625                630                635                640
Ser Ala Ser Lys Thr Lys Lys Gly Met Phe Arg Thr Val Gly Gln Leu 
                 645                650                655
Tyr Lys Glu Gln Leu Gly Lys Leu Met Thr Thr Leu Arg Asn Thr Thr 
             660                665                670
Pro Asn Phe Val Arg Cys Ile Ile Pro Asn His Glu Lys Arg Ser Gly 
         675                680                685
Lys Leu Asp Ala Phe Leu Val Leu Glu Gln Leu Arg Cys Asn Gly Val 
     690                695                700
Leu Glu Gly Ile Arg Ile Cys Arg Gln Gly Phe Pro Asn Arg Ile Val 
 705                710                715                720
Phe Gln Glu Phe Arg Gln Arg Tyr Glu Ile Leu Ala Ala Asn Ala Ile 
                 725                730                735
Pro Lys Gly Phe Met Asp Gly Lys Gln Ala Cys Ile Leu Met Ile Lys 
             740                745                750
Ala Leu Glu Leu Asp Pro Asn Leu Tyr Arg Ile Gly Gln Ser Lys Ile 
         755                760                765
Phe Phe Arg Thr Gly Val Leu Ala His Leu Glu Glu Glu Arg Asp Leu 
     770                775                780
Lys Ile Thr Asp Val Ile Met Ala Phe Gln Ala Met Cys Arg Gly Tyr 
 785                790                795                800
Leu Ala Arg Lys Ala Phe Ala Lys Arg Gln Gln Gln Leu Thr Ala Met 
                 805                810                815
Lys Val Ile Gln Arg Asn Cys Ala Ala Tyr Leu Lys Leu Arg Asn Trp 
             820                825                830
Gln Trp Trp Arg Leu Phe Thr Lys Val Lys Pro Leu Leu Gln Val Thr 
         835                840                845
Arg Gln Glu Glu Glu Met Gln Ala Lys Glu Asp Glu Leu Gln Lys Thr 
     850                855                860
Lys Glu Arg Gln Gln Lys Ala Glu Asn Glu Leu Lys Glu Leu Glu Gln 
 865                870                875                880
Lys His Ser Gln Leu Thr Glu Glu Lys Asn Leu Leu Gln Glu Gln Leu 
                 885                890                895
Gln Ala Glu Thr Glu Leu Tyr Ala Glu Ala Glu Glu Met Arg Val Arg 
             900                905                910
Leu Ala Ala Lys Lys Gln Glu Leu Glu Glu Ile Leu His Glu Met Glu 
         915                920                925
Ala Arg Leu Glu Glu Glu Glu Asp Arg Gly Gln Gln Leu Gln Ala Glu 
     930                935                940
Arg Lys Lys Met Ala Gln Gln Met Leu Asp Leu Glu Glu Gln Leu Glu 
 945                950                955                960
Glu Glu Glu Ala Ala Arg Gln Lys Leu Gln Leu Glu Lys Val Thr Ala 
                 965                970                975
Glu Ala Lys Ile Lys Lys Leu Glu Asp Glu Ile Leu Val Met Asp Asp 
             980                985                990
Gln Asn Asn Lys Leu Ser Lys Glu Arg Lys Leu Leu Glu Glu Arg Ile 
         995                1000                1005
Ser Asp Leu Thr Thr Asn Leu Ala Glu Glu Glu Glu Lys Ala Lys Asn 
     1010                1015                1020
Leu Thr Lys Leu Lys Asn Lys His Glu Ser Met Ile Ser Glu Leu Glu 
 1025                1030                1035                1040
Val Arg Leu Lys Lys Glu Glu Lys Ser Arg Gln Glu Leu Glu Lys Leu 
                 1045                1050                1055
Lys Arg Lys Leu Glu Gly Asp Ala Ser Asp Phe His Glu Gln Ile Ala 
             1060                1065                1070
Asp Leu Gln Ala Gln Ile Ala Glu Leu Lys Met Gln Leu Ala Lys Lys 
         1075                1080                1085
Glu Glu Glu Leu Gln Ala Ala Leu Ala Arg Leu Asp Asp Glu Ile Ala 
     1090                1095                1100
Gln Lys Asn Asn Ala Leu Lys Lys Ile Arg Glu Leu Glu Gly His Ile 
 1105                1110                1115                1120
Ser Asp Leu Gln Glu Asp Leu Asp Ser Glu Arg Ala Ala Arg Asn Lys 
                 1125                1130                1135
Ala Glu Lys Gln Lys Arg Asp Leu Gly Glu Glu Leu Glu Ala Leu Lys 
             1140                1145                1150
Thr Glu Leu Glu Asp Thr Leu Asp Ser Thr Ala Thr Gln Gln Glu Leu 
         1155                1160                1165
Arg Ala Lys Arg Glu Gln Glu Val Thr Val Leu Lys Lys Ala Leu Asp 
     1170                1175                1180
Glu Glu Thr Arg Ser His Glu Ala Gln Val Gln Glu Met Arg Gln Lys 
 1185                1190                1195                1200
His Ala Gln Ala Val Glu Glu Leu Thr Glu Gln Leu Glu Gln Phe Lys 
                 1205                1210                1215
Arg Ala Lys Ala Asn Leu Asp Lys Asn Lys Gln Thr Leu Glu Lys Glu 
             1220                1225                1230
Asn Ala Asp Leu Ala Gly Glu Leu Arg Val Leu Gly Gln Ala Lys Gln 
         1235                1240                1245
Glu Val Glu His Lys Lys Lys Lys Leu Glu Ala Gln Val Gln Glu Leu 
     1250                1255                1260
Gln Ser Lys Cys Ser Asp Gly Glu Arg Ala Arg Ala Glu Leu Asn Asp 
 1265                1270                1275                1280
Lys Val His Lys Leu Gln Asn Glu Val Glu Ser Val Thr Gly Met Leu 
                 1285                1290                1295
Asn Glu Ala Glu Gly Lys Ala Ile Lys Leu Ala Lys Asp Val Ala Ser 
             1300                1305                1310
Leu Ser Ser Gln Leu Gln Asp Thr Gln Glu Leu Leu Gln Glu Glu Thr 
         1315                1320                1325
Arg Gln Lys Leu Asn Val Ser Thr Lys Leu Arg Gln Leu Glu Glu Glu 
     1330                1335                1340
Arg Asn Ser Leu Gln Asp Gln Leu Asp Glu Glu Met Glu Ala Lys Gln 
 1345                1350                1355                1360
Asn Leu Glu Arg His Ile Ser Thr Leu Asn Ile Gln Leu Ser Asp Ser 
                 1365                1370                1375
Lys Lys Lys Leu Gln Asp Phe Ala Ser Thr Val Glu Ala Leu Glu Glu 
             1380                1385                1390
Gly Lys Lys Arg Phe Gln Lys Glu Ile Glu Asn Leu Thr Gln Gln Tyr 
         1395                1400                1405
Glu Glu Lys Ala Ala Ala Tyr Asp Lys Leu Glu Lys Thr Lys Asn Arg 
     1410                1415                1420
Leu Gln Gln Glu Leu Asp Asp Leu Val Val Asp Leu Asp Asn Gln Arg 
 1425                1430                1435                1440
Gln Leu Val Ser Asn Leu Glu Lys Lys Gln Arg Lys Phe Asp Gln Leu 
                 1445                1450                1455
Leu Ala Glu Glu Lys Asn Ile Ser Ser Lys Tyr Ala Asp Glu Arg Asp 
             1460                1465                1470
Arg Ala Glu Ala Glu Ala Arg Glu Lys Glu Thr Lys Ala Leu Ser Leu 
         1475                1480                1485
Ala Arg Ala Leu Glu Glu Ala Leu Glu Ala Lys Glu Glu Leu Glu Arg 
     1490                1495                1500
Thr Asn Lys Met Leu Lys Ala Glu Met Glu Asp Leu Val Ser Ser Lys 
 1505                1510                1515                1520
Asp Asp Val Gly Lys Asn Val His Glu Leu Glu Lys Ser Lys Arg Ala 
                 1525                1530                1535
Leu Glu Thr Gln Met Glu Glu Met Lys Thr Gln Leu Glu Glu Leu Glu 
             1540                1545                1550
Asp Glu Leu Gln Ala Thr Glu Asp Ala Lys Leu Arg Leu Glu Val Asn 
         1555                1560                1565
Met Gln Ala Leu Lys Gly Gln Phe Glu Arg Asp Leu Gln Ala Arg Asp 
     1570                1575                1580
Glu Gln Asn Glu Glu Lys Arg Arg Gln Leu Gln Arg Gln Leu His Glu 
 1585                1590                1595                1600
Tyr Glu Thr Glu Leu Glu Asp Glu Arg Lys Gln Arg Ala Leu Ala Ala 
                 1605                1610                1615
Ala Ala Lys Lys Lys Leu Glu Gly Asp Leu Lys Asp Leu Glu Leu Gln 
             1620                1625                1630
Ala Asp Ser Ala Ile Lys Gly Arg Glu Glu Ala Ile Lys Gln Leu Arg 
         1635                1640                1645
Lys Leu Gln Ala Gln Met Lys Asp Phe Gln Arg Glu Leu Glu Asp Ala 
     1650                1655                1660
Arg Ala Ser Arg Asp Glu Ile Phe Ala Thr Ala Lys Glu Asn Glu Lys 
 1665                1670                1675                1680
Lys Ala Lys Ser Leu Glu Ala Asp Leu Met Gln Leu Gln Glu Asp Leu 
                 1685                1690                1695
Ala Ala Ala Glu Arg Ala Arg Lys Gln Ala Asp Leu Glu Lys Glu Glu 
             1700                1705                1710
Leu Ala Glu Glu Leu Ala Ser Ser Leu Ser Gly Arg Asn Ala Leu Gln 
         1715                1720                1725
Asp Glu Lys Arg Arg Leu Glu Ala Arg Ile Ala Gln Leu Glu Glu Glu 
     1730                1735                1740
Leu Glu Glu Glu Gln Gly Asn Met Glu Ala Met Ser Asp Arg Val Arg 
 1745                1750                1755                1760
Lys Ala Thr Gln Gln Ala Glu Gln Leu Ser Asn Glu Leu Ala Thr Glu 
                 1765                1770                1775
Arg Ser Thr Ala Gln Lys Asn Glu Ser Ala Arg Gln Gln Leu Glu Arg 
             1780                1785                1790
Gln Asn Lys Glu Leu Arg Ser Lys Leu His Glu Met Glu Gly Ala Val 
         1795                1800                1805
Lys Ser Lys Phe Lys Ser Thr Ile Ala Ala Leu Glu Ala Lys Ile Ala 
     1810                1815                1820
Gln Leu Glu Glu Gln Val Glu Gln Glu Ala Arg Glu Lys Gln Ala Ala 
 1825                1830                1835                1840
Thr Lys Ser Leu Lys Gln Lys Asp Lys Lys Leu Lys Glu Ile Leu Leu 
                 1845                1850                1855
Gln Val Glu Asp Glu Arg Lys Met Ala Glu Gln Tyr Lys Glu Gln Ala 
             1860                1865                1870
Glu Lys Gly Asn Ala Arg Val Lys Gln Leu Lys Arg Gln Leu Glu Glu 
         1875                1880                1885
Ala Glu Glu Glu Ser Gln Arg Ile Asn Ala Asn Arg Arg Lys Leu Gln 
     1890                1895                1900
Arg Glu Leu Asp Glu Ala Thr Glu Ser Asn Glu Ala Met Gly Arg Glu 
 1905                1910                1915                1920
Val Asn Ala Leu Lys Ser Lys Leu Arg Arg Gly Asn Glu Thr Ser Phe 
                 1925                1930                1935
Val Pro Ser Arg Arg Ser Gly Gly Arg Arg Val Ile Glu Asn Ala Asp 
             1940                1945                1950
Gly Ser Glu Glu Glu Thr Asp Thr Arg Asp Ala Asp Phe Asn Gly Thr 
         1955                1960                1965
Lys Ala Ser Glu 
     1970



<210> 9465
<211> 606
<212> DNA
<213> Rattus norvegicus
<308> X16273
<400> 9465

gttgatttg  tgaaacagc  ggacgaaga  acggttttt  ccctggtga  ttacatttt  60
tttaaaggc  agtggaaga  gccattcaa  cctgagcac  ctagggatg  tgactttca  120
gtagacaag  ccaccacag  gaaggtgcc  atgatgaac  gcctgggca  gtttgacat  180
cactattgc  gcacactgt  cagctgggt  ctgatgatg  attacctgg  caacgccac  240
gccatcttc  tcctgcccg  tgatggcaa  atgcagcat  tggagcaaa  tctcaccaa  300
gatctcatt  cccggttcc  gctaaacag  caaacaagg  cagccattc  ctacttccc  360
aaactgtcc  tctctggaa  ctataactt  aagacactc  tggactcac  gggcatcac  420
cgggtcttc  acaatgatg  tgatctctc  ggaatcaca  aggatgccc  cctgaagct  480
agccaggct  tgcataagg  tgtgctgac  ttagatgag  ggggaacag  ggctgcagg  540
gccactgtg  tggaggccg  ccccatgtc  ctgccccct  aagtgaagt  cgaccaccc  600
ttcatc  606



<210> 9466
<211> 411
<212> PRT
<213> Rattus norvegicus
<308> CAA34349
<400> 9466

Met Ala Pro Ser Ile Ser Arg Gly Leu Leu Leu Leu Ala Ala Leu Cys 
  1               5                  10                  15
Cys Leu Ala Pro Ser Phe Leu Ala Glu Asp Ala Gln Glu Thr Asp Thr 
             20                  25                  30
Ser Gln Gln Asp Gln Ser Pro Thr Tyr Arg Lys Ile Ser Ser Asn Leu 
         35                  40                  45
Ala Asp Phe Ala Phe Ser Leu Tyr Arg Glu Leu Val His Gln Ser Asn 
     50                  55                  60
Thr Ser Asn Ile Phe Phe Ser Pro Met Ser Ile Thr Thr Ala Phe Ala 
 65                  70                  75                  80
Met Leu Ser Leu Gly Ser Lys Gly Asp Thr Arg Lys Gln Ile Leu Glu 
                 85                  90                  95
Gly Leu Glu Phe Asn Leu Thr Gln Ile Pro Glu Ala Asp Ile His Lys 
             100                105                110
Ala Phe His His Leu Leu Gln Thr Leu Asn Arg Pro Asp Ser Glu Leu 
         115                120                125
Gln Leu Asn Thr Gly Asn Gly Leu Phe Val Asn Lys Asn Leu Lys Leu 
     130                135                140
Val Glu Lys Phe Leu Glu Glu Val Lys Asn Asn Tyr His Ser Glu Ala 
 145                150                155                160
Phe Ser Val Asn Phe Ala Asp Ser Glu Glu Ala Lys Lys Val Ile Asn 
                 165                170                175
Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Met Lys 
             180                185                190
Gln Leu Asp Glu Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe 
         195                200                205
Lys Gly Lys Trp Lys Arg Pro Phe Asn Pro Glu His Thr Arg Asp Ala 
     210                215                220
Asp Phe His Val Asp Lys Ser Thr Thr Val Lys Val Pro Met Met Asn 
 225                230                235                240
Arg Leu Gly Met Phe Asp Met His Tyr Cys Ser Thr Leu Ser Ser Trp 
                 245                250                255
Val Leu Met Met Asp Tyr Leu Gly Asn Ala Thr Ala Ile Phe Leu Leu 
             260                265                270
Pro Asp Asp Gly Lys Met Gln His Leu Glu Gln Thr Leu Thr Lys Asp 
         275                280                285
Leu Ile Ser Arg Phe Leu Leu Asn Arg Gln Thr Arg Ser Ala Ile Leu 
     290                295                300
Tyr Phe Pro Lys Leu Ser Ile Ser Gly Thr Tyr Asn Leu Lys Thr Leu 
 305                310                315                320
Leu Ser Ser Leu Gly Ile Thr Arg Val Phe Asn Asn Asp Ala Asp Leu 
                 325                330                335
Ser Gly Ile Thr Glu Asp Ala Pro Leu Lys Leu Ser Gln Ala Val His 
             340                345                350
Lys Ala Val Leu Thr Leu Asp Glu Arg Gly Thr Glu Ala Ala Gly Ala 
         355                360                365
Thr Val Val Glu Ala Val Pro Met Ser Leu Pro Pro Gln Val Lys Phe 
     370                375                380
Asp His Pro Phe Ile Phe Met Ile Val Glu Ser Glu Thr Gln Ser Pro 
 385                390                395                400
Leu Phe Val Gly Lys Val Ile Asp Pro Thr Arg 
                 405                410



<210> 9467
<211> 1584
<212> DNA
<213> Homo sapiens
<308> NM_000295
<400> 9467

aagctgtac  ctgcccagg  aaagcgtcc  ggcagcgta  gcgggcgac  cagatccca  60
ccagtggac  tagcccctg  ttgctcctc  gataactgg  gtgaccttg  ttaatattc  120
ccagcagcc  cccccgttg  ccctctgga  ccactgctt  aatacggac  aggacaggg  180
cctgtctcc  cagcttcag  caccaccac  gacctggga  agtgaatcg  caatgccgt  240
ttctgtctc  tggggcatc  tcctgctgg  aggcctgtg  tgcctggtc  ctgtctccc  300
ggctgagga  ccccaggga  atgctgccc  gaagacaga  acatcccac  atgatcagg  360
tcacccaac  ttcaacaag  tcaccccca  cctggctga  ttcgccttc  gcctatacc  420
ccagctggc  caccagtcc  acagcacca  tatcttctt  tccccagtg  gcatcgcta  480
agcctttgc  atgctctcc  tggggacca  ggctgacac  cacgatgaa  tcctggagg  540
cctgaattt  aacctcacg  agattccgg  ggctcagat  catgaaggc  tccaggaac  600
cctccgtac  ctcaaccag  cagacagcc  gctccagct  accaccggc  atggcttgt  660
cctcagcga  ggcctgaag  tagtggata  gtttttgga  gatgttaaa  agttgtacc  720
ctcagaagc  ttcactgtc  acttcgggg  caccgaaga  gccaagaaa  agatcaacg  780
ttacgtgga  aagggtact  aagggaaaa  tgtggattt  gtcaaggag  ttgacagag  840
cacagtttt  gctctggtg  attacatct  ctttaaagg  aaatgggag  gaccctttg  900
agtcaagga  accgaggaa  aggacttcc  cgtggacca  gtgaccacc  tgaaggtgc  960
tatgatgaa  cgtttaggc  tgtttaaca  ccagcactg  aagaagctg  ccagctggg  1020
gctgctgat  aaatacctg  gcaatgcca  cgccatctt  ttcctgcct  atgagggga  1080
actacagca  ctggaaaat  aactcaccc  cgatatcat  accaagttc  tggaaaatg  1140
agacagaag  tctgccagc  tacatttac  caaactgtc  attactgga  cctatgatc  1200
gaagagcgt  ctgggtcaa  tgggcatca  taaggtctt  agcaatggg  ctgacctct  1260
cggggtcac  gaggaggca  ccctgaagc  ctccaaggc  gtgcataag  ctgtgctga  1320
catcgacga  aaagggact  aagctgctg  ggccatgtt  ttagaggcc  tacccatgt  1380
tatcccccc  gaggtcaag  tcaacaaac  ctttgtctt  ttaatgatt  accaaaata  1440
caagtctcc  ctcttcatg  gaaaagtgg  gaatcccac  caaaaataa  tgcctctcg  1500
tcctcaacc  ctcccctcc  tccctggcc  cctccctgg  tgacattaa  gaagggttg  1560
gctggaaaa  aaaaaaaaa  aaaa  1584



<210> 9468
<211> 418
<212> PRT
<213> Homo sapiens
<308> P01009
<400> 9468

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
  1               5                  10                  15
Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
             20                  25                  30
Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
         35                  40                  45
Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
     50                  55                  60
Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
 65                  70                  75                  80
Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                 85                  90                  95
His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
             100                105                110
Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
         115                120                125
Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
     130                135                140
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
 145                150                155                160
Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                 165                170                175
Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
             180                185                190
Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
         195                200                205
Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
     210                215                220
Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
 225                230                235                240
Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                 245                250                255
Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
             260                265                270
Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
         275                280                285
Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
     290                295                300
Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
 305                310                315                320
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                 325                330                335
Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
             340                345                350
Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
         355                360                365
Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
     370                375                380
Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
 385                390                395                400
Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                 405                410                415
Gln Lys 
             420



<210> 9469
<211> 606
<212> DNA
<213> Rattus norvegicus
<308> X16273
<400> 9469

gttgatttg  tgaaacagc  ggacgaaga  acggttttt  ccctggtga  ttacatttt  60
tttaaaggc  agtggaaga  gccattcaa  cctgagcac  ctagggatg  tgactttca  120
gtagacaag  ccaccacag  gaaggtgcc  atgatgaac  gcctgggca  gtttgacat  180
cactattgc  gcacactgt  cagctgggt  ctgatgatg  attacctgg  caacgccac  240
gccatcttc  tcctgcccg  tgatggcaa  atgcagcat  tggagcaaa  tctcaccaa  300
gatctcatt  cccggttcc  gctaaacag  caaacaagg  cagccattc  ctacttccc  360
aaactgtcc  tctctggaa  ctataactt  aagacactc  tggactcac  gggcatcac  420
cgggtcttc  acaatgatg  tgatctctc  ggaatcaca  aggatgccc  cctgaagct  480
agccaggct  tgcataagg  tgtgctgac  ttagatgag  ggggaacag  ggctgcagg  540
gccactgtg  tggaggccg  ccccatgtc  ctgccccct  aagtgaagt  cgaccaccc  600
ttcatc  606



<210> 9470
<211> 411
<212> PRT
<213> Rattus norvegicus
<308> CAA34349
<400> 9470

Met Ala Pro Ser Ile Ser Arg Gly Leu Leu Leu Leu Ala Ala Leu Cys 
  1               5                  10                  15
Cys Leu Ala Pro Ser Phe Leu Ala Glu Asp Ala Gln Glu Thr Asp Thr 
             20                  25                  30
Ser Gln Gln Asp Gln Ser Pro Thr Tyr Arg Lys Ile Ser Ser Asn Leu 
         35                  40                  45
Ala Asp Phe Ala Phe Ser Leu Tyr Arg Glu Leu Val His Gln Ser Asn 
     50                  55                  60
Thr Ser Asn Ile Phe Phe Ser Pro Met Ser Ile Thr Thr Ala Phe Ala 
 65                  70                  75                  80
Met Leu Ser Leu Gly Ser Lys Gly Asp Thr Arg Lys Gln Ile Leu Glu 
                 85                  90                  95
Gly Leu Glu Phe Asn Leu Thr Gln Ile Pro Glu Ala Asp Ile His Lys 
             100                105                110
Ala Phe His His Leu Leu Gln Thr Leu Asn Arg Pro Asp Ser Glu Leu 
         115                120                125
Gln Leu Asn Thr Gly Asn Gly Leu Phe Val Asn Lys Asn Leu Lys Leu 
     130                135                140
Val Glu Lys Phe Leu Glu Glu Val Lys Asn Asn Tyr His Ser Glu Ala 
 145                150                155                160
Phe Ser Val Asn Phe Ala Asp Ser Glu Glu Ala Lys Lys Val Ile Asn 
                 165                170                175
Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Met Lys 
             180                185                190
Gln Leu Asp Glu Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe 
         195                200                205
Lys Gly Lys Trp Lys Arg Pro Phe Asn Pro Glu His Thr Arg Asp Ala 
     210                215                220
Asp Phe His Val Asp Lys Ser Thr Thr Val Lys Val Pro Met Met Asn 
 225                230                235                240
Arg Leu Gly Met Phe Asp Met His Tyr Cys Ser Thr Leu Ser Ser Trp 
                 245                250                255
Val Leu Met Met Asp Tyr Leu Gly Asn Ala Thr Ala Ile Phe Leu Leu 
             260                265                270
Pro Asp Asp Gly Lys Met Gln His Leu Glu Gln Thr Leu Thr Lys Asp 
         275                280                285
Leu Ile Ser Arg Phe Leu Leu Asn Arg Gln Thr Arg Ser Ala Ile Leu 
     290                295                300
Tyr Phe Pro Lys Leu Ser Ile Ser Gly Thr Tyr Asn Leu Lys Thr Leu 
 305                310                315                320
Leu Ser Ser Leu Gly Ile Thr Arg Val Phe Asn Asn Asp Ala Asp Leu 
                 325                330                335
Ser Gly Ile Thr Glu Asp Ala Pro Leu Lys Leu Ser Gln Ala Val His 
             340                345                350
Lys Ala Val Leu Thr Leu Asp Glu Arg Gly Thr Glu Ala Ala Gly Ala 
         355                360                365
Thr Val Val Glu Ala Val Pro Met Ser Leu Pro Pro Gln Val Lys Phe 
     370                375                380
Asp His Pro Phe Ile Phe Met Ile Val Glu Ser Glu Thr Gln Ser Pro 
 385                390                395                400
Leu Phe Val Gly Lys Val Ile Asp Pro Thr Arg 
                 405                410



<210> 9471
<211> 1584
<212> DNA
<213> Homo sapiens
<308> NM_000295
<400> 9471

aagctgtac  ctgcccagg  aaagcgtcc  ggcagcgta  gcgggcgac  cagatccca  60
ccagtggac  tagcccctg  ttgctcctc  gataactgg  gtgaccttg  ttaatattc  120
ccagcagcc  cccccgttg  ccctctgga  ccactgctt  aatacggac  aggacaggg  180
cctgtctcc  cagcttcag  caccaccac  gacctggga  agtgaatcg  caatgccgt  240
ttctgtctc  tggggcatc  tcctgctgg  aggcctgtg  tgcctggtc  ctgtctccc  300
ggctgagga  ccccaggga  atgctgccc  gaagacaga  acatcccac  atgatcagg  360
tcacccaac  ttcaacaag  tcaccccca  cctggctga  ttcgccttc  gcctatacc  420
ccagctggc  caccagtcc  acagcacca  tatcttctt  tccccagtg  gcatcgcta  480
agcctttgc  atgctctcc  tggggacca  ggctgacac  cacgatgaa  tcctggagg  540
cctgaattt  aacctcacg  agattccgg  ggctcagat  catgaaggc  tccaggaac  600
cctccgtac  ctcaaccag  cagacagcc  gctccagct  accaccggc  atggcttgt  660
cctcagcga  ggcctgaag  tagtggata  gtttttgga  gatgttaaa  agttgtacc  720
ctcagaagc  ttcactgtc  acttcgggg  caccgaaga  gccaagaaa  agatcaacg  780
ttacgtgga  aagggtact  aagggaaaa  tgtggattt  gtcaaggag  ttgacagag  840
cacagtttt  gctctggtg  attacatct  ctttaaagg  aaatgggag  gaccctttg  900
agtcaagga  accgaggaa  aggacttcc  cgtggacca  gtgaccacc  tgaaggtgc  960
tatgatgaa  cgtttaggc  tgtttaaca  ccagcactg  aagaagctg  ccagctggg  1020
gctgctgat  aaatacctg  gcaatgcca  cgccatctt  ttcctgcct  atgagggga  1080
actacagca  ctggaaaat  aactcaccc  cgatatcat  accaagttc  tggaaaatg  1140
agacagaag  tctgccagc  tacatttac  caaactgtc  attactgga  cctatgatc  1200
gaagagcgt  ctgggtcaa  tgggcatca  taaggtctt  agcaatggg  ctgacctct  1260
cggggtcac  gaggaggca  ccctgaagc  ctccaaggc  gtgcataag  ctgtgctga  1320
catcgacga  aaagggact  aagctgctg  ggccatgtt  ttagaggcc  tacccatgt  1380
tatcccccc  gaggtcaag  tcaacaaac  ctttgtctt  ttaatgatt  accaaaata  1440
caagtctcc  ctcttcatg  gaaaagtgg  gaatcccac  caaaaataa  tgcctctcg  1500
tcctcaacc  ctcccctcc  tccctggcc  cctccctgg  tgacattaa  gaagggttg  1560
gctggaaaa  aaaaaaaaa  aaaa  1584



<210> 9472
<211> 418
<212> PRT
<213> Homo sapiens
<308> P01009
<400> 9472

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
  1               5                  10                  15
Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
             20                  25                  30
Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
         35                  40                  45
Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
     50                  55                  60
Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
 65                  70                  75                  80
Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                 85                  90                  95
His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
             100                105                110
Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
         115                120                125
Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
     130                135                140
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
 145                150                155                160
Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                 165                170                175
Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
             180                185                190
Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
         195                200                205
Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
     210                215                220
Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
 225                230                235                240
Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                 245                250                255
Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
             260                265                270
Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
         275                280                285
Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
     290                295                300
Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
 305                310                315                320
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                 325                330                335
Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
             340                345                350
Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
         355                360                365
Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
     370                375                380
Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
 385                390                395                400
Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                 405                410                415
Gln Lys 
             420



<210> 9473
<211> 606
<212> DNA
<213> Rattus norvegicus
<308> X16273
<400> 9473

gttgatttg  tgaaacagc  ggacgaaga  acggttttt  ccctggtga  ttacatttt  60
tttaaaggc  agtggaaga  gccattcaa  cctgagcac  ctagggatg  tgactttca  120
gtagacaag  ccaccacag  gaaggtgcc  atgatgaac  gcctgggca  gtttgacat  180
cactattgc  gcacactgt  cagctgggt  ctgatgatg  attacctgg  caacgccac  240
gccatcttc  tcctgcccg  tgatggcaa  atgcagcat  tggagcaaa  tctcaccaa  300
gatctcatt  cccggttcc  gctaaacag  caaacaagg  cagccattc  ctacttccc  360
aaactgtcc  tctctggaa  ctataactt  aagacactc  tggactcac  gggcatcac  420
cgggtcttc  acaatgatg  tgatctctc  ggaatcaca  aggatgccc  cctgaagct  480
agccaggct  tgcataagg  tgtgctgac  ttagatgag  ggggaacag  ggctgcagg  540
gccactgtg  tggaggccg  ccccatgtc  ctgccccct  aagtgaagt  cgaccaccc  600
ttcatc  606



<210> 9474
<211> 411
<212> PRT
<213> Rattus norvegicus
<308> CAA34349
<400> 9474

Met Ala Pro Ser Ile Ser Arg Gly Leu Leu Leu Leu Ala Ala Leu Cys 
  1               5                  10                  15
Cys Leu Ala Pro Ser Phe Leu Ala Glu Asp Ala Gln Glu Thr Asp Thr 
             20                  25                  30
Ser Gln Gln Asp Gln Ser Pro Thr Tyr Arg Lys Ile Ser Ser Asn Leu 
         35                  40                  45
Ala Asp Phe Ala Phe Ser Leu Tyr Arg Glu Leu Val His Gln Ser Asn 
     50                  55                  60
Thr Ser Asn Ile Phe Phe Ser Pro Met Ser Ile Thr Thr Ala Phe Ala 
 65                  70                  75                  80
Met Leu Ser Leu Gly Ser Lys Gly Asp Thr Arg Lys Gln Ile Leu Glu 
                 85                  90                  95
Gly Leu Glu Phe Asn Leu Thr Gln Ile Pro Glu Ala Asp Ile His Lys 
             100                105                110
Ala Phe His His Leu Leu Gln Thr Leu Asn Arg Pro Asp Ser Glu Leu 
         115                120                125
Gln Leu Asn Thr Gly Asn Gly Leu Phe Val Asn Lys Asn Leu Lys Leu 
     130                135                140
Val Glu Lys Phe Leu Glu Glu Val Lys Asn Asn Tyr His Ser Glu Ala 
 145                150                155                160
Phe Ser Val Asn Phe Ala Asp Ser Glu Glu Ala Lys Lys Val Ile Asn 
                 165                170                175
Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Met Lys 
             180                185                190
Gln Leu Asp Glu Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe 
         195                200                205
Lys Gly Lys Trp Lys Arg Pro Phe Asn Pro Glu His Thr Arg Asp Ala 
     210                215                220
Asp Phe His Val Asp Lys Ser Thr Thr Val Lys Val Pro Met Met Asn 
 225                230                235                240
Arg Leu Gly Met Phe Asp Met His Tyr Cys Ser Thr Leu Ser Ser Trp 
                 245                250                255
Val Leu Met Met Asp Tyr Leu Gly Asn Ala Thr Ala Ile Phe Leu Leu 
             260                265                270
Pro Asp Asp Gly Lys Met Gln His Leu Glu Gln Thr Leu Thr Lys Asp 
         275                280                285
Leu Ile Ser Arg Phe Leu Leu Asn Arg Gln Thr Arg Ser Ala Ile Leu 
     290                295                300
Tyr Phe Pro Lys Leu Ser Ile Ser Gly Thr Tyr Asn Leu Lys Thr Leu 
 305                310                315                320
Leu Ser Ser Leu Gly Ile Thr Arg Val Phe Asn Asn Asp Ala Asp Leu 
                 325                330                335
Ser Gly Ile Thr Glu Asp Ala Pro Leu Lys Leu Ser Gln Ala Val His 
             340                345                350
Lys Ala Val Leu Thr Leu Asp Glu Arg Gly Thr Glu Ala Ala Gly Ala 
         355                360                365
Thr Val Val Glu Ala Val Pro Met Ser Leu Pro Pro Gln Val Lys Phe 
     370                375                380
Asp His Pro Phe Ile Phe Met Ile Val Glu Ser Glu Thr Gln Ser Pro 
 385                390                395                400
Leu Phe Val Gly Lys Val Ile Asp Pro Thr Arg 
                 405                410



<210> 9475
<211> 1584
<212> DNA
<213> Homo sapiens
<308> NM_000295
<400> 9475

aagctgtac  ctgcccagg  aaagcgtcc  ggcagcgta  gcgggcgac  cagatccca  60
ccagtggac  tagcccctg  ttgctcctc  gataactgg  gtgaccttg  ttaatattc  120
ccagcagcc  cccccgttg  ccctctgga  ccactgctt  aatacggac  aggacaggg  180
cctgtctcc  cagcttcag  caccaccac  gacctggga  agtgaatcg  caatgccgt  240
ttctgtctc  tggggcatc  tcctgctgg  aggcctgtg  tgcctggtc  ctgtctccc  300
ggctgagga  ccccaggga  atgctgccc  gaagacaga  acatcccac  atgatcagg  360
tcacccaac  ttcaacaag  tcaccccca  cctggctga  ttcgccttc  gcctatacc  420
ccagctggc  caccagtcc  acagcacca  tatcttctt  tccccagtg  gcatcgcta  480
agcctttgc  atgctctcc  tggggacca  ggctgacac  cacgatgaa  tcctggagg  540
cctgaattt  aacctcacg  agattccgg  ggctcagat  catgaaggc  tccaggaac  600
cctccgtac  ctcaaccag  cagacagcc  gctccagct  accaccggc  atggcttgt  660
cctcagcga  ggcctgaag  tagtggata  gtttttgga  gatgttaaa  agttgtacc  720
ctcagaagc  ttcactgtc  acttcgggg  caccgaaga  gccaagaaa  agatcaacg  780
ttacgtgga  aagggtact  aagggaaaa  tgtggattt  gtcaaggag  ttgacagag  840
cacagtttt  gctctggtg  attacatct  ctttaaagg  aaatgggag  gaccctttg  900
agtcaagga  accgaggaa  aggacttcc  cgtggacca  gtgaccacc  tgaaggtgc  960
tatgatgaa  cgtttaggc  tgtttaaca  ccagcactg  aagaagctg  ccagctggg  1020
gctgctgat  aaatacctg  gcaatgcca  cgccatctt  ttcctgcct  atgagggga  1080
actacagca  ctggaaaat  aactcaccc  cgatatcat  accaagttc  tggaaaatg  1140
agacagaag  tctgccagc  tacatttac  caaactgtc  attactgga  cctatgatc  1200
gaagagcgt  ctgggtcaa  tgggcatca  taaggtctt  agcaatggg  ctgacctct  1260
cggggtcac  gaggaggca  ccctgaagc  ctccaaggc  gtgcataag  ctgtgctga  1320
catcgacga  aaagggact  aagctgctg  ggccatgtt  ttagaggcc  tacccatgt  1380
tatcccccc  gaggtcaag  tcaacaaac  ctttgtctt  ttaatgatt  accaaaata  1440
caagtctcc  ctcttcatg  gaaaagtgg  gaatcccac  caaaaataa  tgcctctcg  1500
tcctcaacc  ctcccctcc  tccctggcc  cctccctgg  tgacattaa  gaagggttg  1560
gctggaaaa  aaaaaaaaa  aaaa  1584



<210> 9476
<211> 418
<212> PRT
<213> Homo sapiens
<308> P01009
<400> 9476

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
  1               5                  10                  15
Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
             20                  25                  30
Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
         35                  40                  45
Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
     50                  55                  60
Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
 65                  70                  75                  80
Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                 85                  90                  95
His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
             100                105                110
Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
         115                120                125
Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
     130                135                140
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
 145                150                155                160
Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                 165                170                175
Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
             180                185                190
Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
         195                200                205
Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
     210                215                220
Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
 225                230                235                240
Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                 245                250                255
Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
             260                265                270
Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
         275                280                285
Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
     290                295                300
Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
 305                310                315                320
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                 325                330                335
Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
             340                345                350
Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
         355                360                365
Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
     370                375                380
Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
 385                390                395                400
Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                 405                410                415
Gln Lys 
             420



<210> 9477
<211> 606
<212> DNA
<213> Rattus norvegicus
<308> X16273
<400> 9477

gttgatttg  tgaaacagc  ggacgaaga  acggttttt  ccctggtga  ttacatttt  60
tttaaaggc  agtggaaga  gccattcaa  cctgagcac  ctagggatg  tgactttca  120
gtagacaag  ccaccacag  gaaggtgcc  atgatgaac  gcctgggca  gtttgacat  180
cactattgc  gcacactgt  cagctgggt  ctgatgatg  attacctgg  caacgccac  240
gccatcttc  tcctgcccg  tgatggcaa  atgcagcat  tggagcaaa  tctcaccaa  300
gatctcatt  cccggttcc  gctaaacag  caaacaagg  cagccattc  ctacttccc  360
aaactgtcc  tctctggaa  ctataactt  aagacactc  tggactcac  gggcatcac  420
cgggtcttc  acaatgatg  tgatctctc  ggaatcaca  aggatgccc  cctgaagct  480
agccaggct  tgcataagg  tgtgctgac  ttagatgag  ggggaacag  ggctgcagg  540
gccactgtg  tggaggccg  ccccatgtc  ctgccccct  aagtgaagt  cgaccaccc  600
ttcatc  606



<210> 9478
<211> 411
<212> PRT
<213> Rattus norvegicus
<308> CAA34349
<400> 9478

Met Ala Pro Ser Ile Ser Arg Gly Leu Leu Leu Leu Ala Ala Leu Cys 
  1               5                  10                  15
Cys Leu Ala Pro Ser Phe Leu Ala Glu Asp Ala Gln Glu Thr Asp Thr 
             20                  25                  30
Ser Gln Gln Asp Gln Ser Pro Thr Tyr Arg Lys Ile Ser Ser Asn Leu 
         35                  40                  45
Ala Asp Phe Ala Phe Ser Leu Tyr Arg Glu Leu Val His Gln Ser Asn 
     50                  55                  60
Thr Ser Asn Ile Phe Phe Ser Pro Met Ser Ile Thr Thr Ala Phe Ala 
 65                  70                  75                  80
Met Leu Ser Leu Gly Ser Lys Gly Asp Thr Arg Lys Gln Ile Leu Glu 
                 85                  90                  95
Gly Leu Glu Phe Asn Leu Thr Gln Ile Pro Glu Ala Asp Ile His Lys 
             100                105                110
Ala Phe His His Leu Leu Gln Thr Leu Asn Arg Pro Asp Ser Glu Leu 
         115                120                125
Gln Leu Asn Thr Gly Asn Gly Leu Phe Val Asn Lys Asn Leu Lys Leu 
     130                135                140
Val Glu Lys Phe Leu Glu Glu Val Lys Asn Asn Tyr His Ser Glu Ala 
 145                150                155                160
Phe Ser Val Asn Phe Ala Asp Ser Glu Glu Ala Lys Lys Val Ile Asn 
                 165                170                175
Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Met Lys 
             180                185                190
Gln Leu Asp Glu Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe 
         195                200                205
Lys Gly Lys Trp Lys Arg Pro Phe Asn Pro Glu His Thr Arg Asp Ala 
     210                215                220
Asp Phe His Val Asp Lys Ser Thr Thr Val Lys Val Pro Met Met Asn 
 225                230                235                240
Arg Leu Gly Met Phe Asp Met His Tyr Cys Ser Thr Leu Ser Ser Trp 
                 245                250                255
Val Leu Met Met Asp Tyr Leu Gly Asn Ala Thr Ala Ile Phe Leu Leu 
             260                265                270
Pro Asp Asp Gly Lys Met Gln His Leu Glu Gln Thr Leu Thr Lys Asp 
         275                280                285
Leu Ile Ser Arg Phe Leu Leu Asn Arg Gln Thr Arg Ser Ala Ile Leu 
     290                295                300
Tyr Phe Pro Lys Leu Ser Ile Ser Gly Thr Tyr Asn Leu Lys Thr Leu 
 305                310                315                320
Leu Ser Ser Leu Gly Ile Thr Arg Val Phe Asn Asn Asp Ala Asp Leu 
                 325                330                335
Ser Gly Ile Thr Glu Asp Ala Pro Leu Lys Leu Ser Gln Ala Val His 
             340                345                350
Lys Ala Val Leu Thr Leu Asp Glu Arg Gly Thr Glu Ala Ala Gly Ala 
         355                360                365
Thr Val Val Glu Ala Val Pro Met Ser Leu Pro Pro Gln Val Lys Phe 
     370                375                380
Asp His Pro Phe Ile Phe Met Ile Val Glu Ser Glu Thr Gln Ser Pro 
 385                390                395                400
Leu Phe Val Gly Lys Val Ile Asp Pro Thr Arg 
                 405                410



<210> 9479
<211> 1584
<212> DNA
<213> Homo sapiens
<308> NM_000295
<400> 9479

aagctgtac  ctgcccagg  aaagcgtcc  ggcagcgta  gcgggcgac  cagatccca  60
ccagtggac  tagcccctg  ttgctcctc  gataactgg  gtgaccttg  ttaatattc  120
ccagcagcc  cccccgttg  ccctctgga  ccactgctt  aatacggac  aggacaggg  180
cctgtctcc  cagcttcag  caccaccac  gacctggga  agtgaatcg  caatgccgt  240
ttctgtctc  tggggcatc  tcctgctgg  aggcctgtg  tgcctggtc  ctgtctccc  300
ggctgagga  ccccaggga  atgctgccc  gaagacaga  acatcccac  atgatcagg  360
tcacccaac  ttcaacaag  tcaccccca  cctggctga  ttcgccttc  gcctatacc  420
ccagctggc  caccagtcc  acagcacca  tatcttctt  tccccagtg  gcatcgcta  480
agcctttgc  atgctctcc  tggggacca  ggctgacac  cacgatgaa  tcctggagg  540
cctgaattt  aacctcacg  agattccgg  ggctcagat  catgaaggc  tccaggaac  600
cctccgtac  ctcaaccag  cagacagcc  gctccagct  accaccggc  atggcttgt  660
cctcagcga  ggcctgaag  tagtggata  gtttttgga  gatgttaaa  agttgtacc  720
ctcagaagc  ttcactgtc  acttcgggg  caccgaaga  gccaagaaa  agatcaacg  780
ttacgtgga  aagggtact  aagggaaaa  tgtggattt  gtcaaggag  ttgacagag  840
cacagtttt  gctctggtg  attacatct  ctttaaagg  aaatgggag  gaccctttg  900
agtcaagga  accgaggaa  aggacttcc  cgtggacca  gtgaccacc  tgaaggtgc  960
tatgatgaa  cgtttaggc  tgtttaaca  ccagcactg  aagaagctg  ccagctggg  1020
gctgctgat  aaatacctg  gcaatgcca  cgccatctt  ttcctgcct  atgagggga  1080
actacagca  ctggaaaat  aactcaccc  cgatatcat  accaagttc  tggaaaatg  1140
agacagaag  tctgccagc  tacatttac  caaactgtc  attactgga  cctatgatc  1200
gaagagcgt  ctgggtcaa  tgggcatca  taaggtctt  agcaatggg  ctgacctct  1260
cggggtcac  gaggaggca  ccctgaagc  ctccaaggc  gtgcataag  ctgtgctga  1320
catcgacga  aaagggact  aagctgctg  ggccatgtt  ttagaggcc  tacccatgt  1380
tatcccccc  gaggtcaag  tcaacaaac  ctttgtctt  ttaatgatt  accaaaata  1440
caagtctcc  ctcttcatg  gaaaagtgg  gaatcccac  caaaaataa  tgcctctcg  1500
tcctcaacc  ctcccctcc  tccctggcc  cctccctgg  tgacattaa  gaagggttg  1560
gctggaaaa  aaaaaaaaa  aaaa  1584



<210> 9480
<211> 418
<212> PRT
<213> Homo sapiens
<308> P01009
<400> 9480

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
  1               5                  10                  15
Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
             20                  25                  30
Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
         35                  40                  45
Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
     50                  55                  60
Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
 65                  70                  75                  80
Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                 85                  90                  95
His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
             100                105                110
Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
         115                120                125
Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
     130                135                140
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
 145                150                155                160
Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                 165                170                175
Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
             180                185                190
Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
         195                200                205
Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
     210                215                220
Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
 225                230                235                240
Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                 245                250                255
Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
             260                265                270
Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
         275                280                285
Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
     290                295                300
Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
 305                310                315                320
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                 325                330                335
Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
             340                345                350
Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
         355                360                365
Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
     370                375                380
Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
 385                390                395                400
Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                 405                410                415
Gln Lys 
             420



<210> 9481
<211> 3348
<212> DNA
<213> Rattus norvegicus
<308> X16476
<400> 9481

aattccggt  gctggtctg  catgacgaa  catggctcg  gctccacca  ctcgctgcc  60
cccgagccc  tggagatcg  gcgcagcaa  gcgtgctcg  gccgggtgc  cctcaacgt  120
gggggcctg  cgcacgagg  gctgtggcg  actctggac  gcctgcccc  cacgcggct  180
ggcaagctt  gggactgca  cacgcacga  tccctgctc  aggtgtgcg  cgactacag  240
cttgaggac  acgagtact  cttcgaccg  caccctggc  cctttacct  cattctcaa  300
ttctaccgc  ccggccggc  gcacatgat  gaggagatg  gcgcgctga  cttcagcca  360
gagctggac  actggggca  cgatgagat  tacctggag  cctgctgcc  ggcccgcta  420
caccaaaag  aggagcaga  gaacgagga  ctgaagcgc  aggccgaga  gctgcggga  480
cgggagggc  aggagtttg  caacacgtg  tgtgcagag  agaggaaga  actctggga  540
ctgctggag  agcccaact  gtcggtggc  gccaagatc  tggccatca  ctcgatcat  600
ttcatcgtc  tgtccacca  cgctctgtc  ctcaacacg  tgcctgagc  gcagagcct  660
gacgagttc  gccagagca  ggataaccc  cagctggcg  acgtggagg  ggtgtgcat  720
gcatggttc  ccatggagt  cttgctgag  ttcctgtcc  cccccaaga  atggaagtt  780
ttcaagggc  ccctcaacg  cattgacct  ctggccatc  tgccctact  cgtcaccat  840
ttcctcaca  aatccaaca  gagcgtgct  cagttccag  acgtgcgcc  cgtggtcca  900
atctttcgc  tcatgcgca  ccttcggat  ctgaagctg  cccgtcact  cactggcct  960
cagtccttg  gcttcaccc  gcgcagaag  tacaacgaa  tgggcctgc  catcctctt  1020
ctcgcgatg  gcatcatga  cttctccag  ctggtcttc  tcgcggaga  ggatgagga  1080
gacaccaag  tcaaaagca  ccccgcctc  ttctggtgg  ctaccatca  catgacaac  1140
gttggctat  gagacatct  cccgaagac  ctcctgggg  aaatcgtgg  ggggctctg  1200
tgcattgcc  gggtcctgg  gattgctct  cccatcccc  tcatcgtca  taacttctc  1260
gagttctac  aggagcaga  gcgccagga  aaagccatc  agcggaggg  ggctctgga  1320
agagccaag  ggaatggca  catcgtgtc  atgaacatg  aggacgcct  cgcccggag  1380
atcgagatg  tggacatcg  ggtggagaa  aatggcgag  gcatagcta  gaaggataa  1440
gtgcaagat  accacctgt  ccccaacaa  tggaaatgg  ccaagaggg  actctccga  1500
accagctcc  gtaagtcct  tgaaaccaa  gagcaggga  cccccgaaa  ggccaggtc  1560
tcgtctagt  cacagcact  gaacgtcca  cagctggaa  acatgtaca  taagatggc  1620
aagacacag  cccagccca  cctcaacac  aaggagatg  ccccgcaga  caagcctcc  1680
gaggagctg  agatgagca  catgcccag  cccgtggcc  ctctgcccg  acgcacgga  1740
ggcgtcatc  acatgcgga  catgtccag  attgacagc  tcatcagct  tgccacgga  1800
ttccctgaa  ccaccagat  ctcccacag  cctctggca  ccctctcca  caaggctgg  1860
agcagcaca  ccccggagg  gggctggcg  ggggctctg  gtgccagcg  cgggaggct  1920
acggagacc  accccattc  tgagaccag  cgctctggt  tcttcgtgg  gagtcccag  1980
agttccatg  agaccaaca  ccccttgaa  ctgcgagcg  tcaaggtca  cttcgtgga  2040
ggcgacccc  ccccgctgc  gccctccct  ggcttgtat  acgatcctc  taggaacag  2100
ggaggggca  cggctgcag  tgcgggact  gagtgtgcc  ccctcttag  caagcccgt  2160
ctgagccca  agtcctcca  ctacaccac  gcaagtgcc  ggacgcccc  tcgctcccc  2220
gagaaacac  cagcaatag  attcaactt  gaggcggga  tccaccatt  catagacac  2280
gacacagat  acgagggtc  gctgctcta  agcgtggac  ccagccctc  caaaagtct  2340
cacgggagt  ccagtccca  gttcagcac  ggagctaga  cggagaaga  ccacttcga  2400
agctccccc  tgcccacct  ccctaagtt  ttaaggccg  actgtgtct  ctcctcaga  2460
gggttgact  gaaaaggcc  tggggctca  gagaaatgc  agctggaga  ccatacccc  2520
ccggatgtg  acatgctgc  tgggggagg  gcacacggg  gcactaggg  tcagagtat  2580
tgagctccc  accacagag  gcatctgca  gagaaatca  ggaggaggg  tgcttggct  2640
gctgccact  agttctgca  gaactccaa  gcccccacc  ccacagagc  ccagcaaga  2700
gagagaccc  gagagccat  accaatctg  ggacactaa  tagccacgg  gaccacacc  2760
aacaacatc  tcctgagat  gccggagca  agctgacag  caccactaa  acctagcct  2820
ggacacaca  tcctagtct  gtctggagg  tctctcagc  tctggatac  ccatcacca  2880
ctctcaagg  ttcagctga  atgggtgtt  gagcgaggg  ttgctagtg  aagagtggg  2940
tgcccaaga  gtactgggt  tcggtctcc  gttaggagg  tgcagagga  ccttgatca  3000
gagggattc  ctgctccgt  agccacact  ctagggcat  gtgatgctt  cataagcaa  3060
tggctcaaa  gattcagta  tctgtggtc  ctggggctt  attcggaga  tctgtcggg  3120
tgagctgac  atttagact  aattctttc  gcccacctg  ccatccagg  agtgttccg  3180
cggttggca  gcagccagg  ctggcacag  aacgtgggt  ccaaacaac  ctcgtatgg  3240
ctgaaaaga  acgcaggcg  caaatatgc  aacgagata  attatttaa  gagactgtg  3300
gtgactgaa  agcaacatt  aaaaataat  aatttcatt  tctacatt  3348



<210> 9482
<211> 853
<212> PRT
<213> Rattus norvegicus
<308> CAA34497
<400> 9482

Met Thr Lys His Gly Ser Arg Ser Thr Ser Ser Leu Pro Pro Glu Pro 
  1               5                  10                  15
Met Glu Ile Val Arg Ser Lys Ala Cys Ser Arg Arg Val Arg Leu Asn 
             20                  25                  30
Val Gly Gly Leu Ala His Glu Val Leu Trp Arg Thr Leu Asp Arg Leu 
         35                  40                  45
Pro Arg Thr Arg Leu Gly Lys Leu Arg Asp Cys Asn Thr His Asp Ser 
     50                  55                  60
Leu Leu Gln Val Cys Asp Asp Tyr Ser Leu Glu Asp Asn Glu Tyr Phe 
 65                  70                  75                  80
Phe Asp Arg His Pro Gly Ala Phe Thr Ser Ile Leu Asn Phe Tyr Arg 
                 85                  90                  95
Thr Gly Arg Leu His Met Met Glu Glu Met Cys Ala Leu Ser Phe Ser 
             100                105                110
Gln Glu Leu Asp Tyr Trp Gly Ile Asp Glu Ile Tyr Leu Glu Ser Cys 
         115                120                125
Cys Gln Ala Arg Tyr His Gln Lys Lys Glu Gln Met Asn Glu Glu Leu 
     130                135                140
Lys Arg Glu Ala Glu Thr Leu Arg Glu Arg Glu Gly Glu Glu Phe Asp 
 145                150                155                160
Asn Thr Cys Cys Ala Glu Lys Arg Lys Lys Leu Trp Asp Leu Leu Glu 
                 165                170                175
Lys Pro Asn Ser Ser Val Ala Ala Lys Ile Leu Ala Ile Ile Ser Ile 
             180                185                190
Met Phe Ile Val Leu Ser Thr Ile Ala Leu Ser Leu Asn Thr Leu Pro 
         195                200                205
Glu Leu Gln Ser Leu Asp Glu Phe Gly Gln Ser Thr Asp Asn Pro Gln 
     210                215                220
Leu Ala His Val Glu Ala Val Cys Ile Ala Trp Phe Thr Met Glu Tyr 
 225                230                235                240
Leu Leu Arg Phe Leu Ser Ser Pro Lys Lys Trp Lys Phe Phe Lys Gly 
                 245                250                255
Pro Leu Asn Ala Ile Asp Leu Leu Ala Ile Leu Pro Tyr Tyr Val Thr 
             260                265                270
Ile Phe Leu Thr Glu Ser Asn Lys Ser Val Leu Gln Phe Gln Asn Val 
         275                280                285
Arg Arg Val Val Gln Ile Phe Arg Ile Met Arg Ile Leu Arg Ile Leu 
     290                295                300
Lys Leu Ala Arg His Ser Thr Gly Leu Gln Ser Leu Gly Phe Thr Leu 
 305                310                315                320
Arg Arg Ser Tyr Asn Glu Leu Gly Leu Leu Ile Leu Phe Leu Ala Met 
                 325                330                335
Gly Ile Met Ile Phe Ser Ser Leu Val Phe Phe Ala Glu Lys Asp Glu 
             340                345                350
Asp Asp Thr Lys Phe Lys Ser Ile Pro Ala Ser Phe Trp Trp Ala Thr 
         355                360                365
Ile Thr Met Thr Thr Val Gly Tyr Gly Asp Ile Tyr Pro Lys Thr Leu 
     370                375                380
Leu Gly Lys Ile Val Gly Gly Leu Cys Cys Ile Ala Gly Val Leu Val 
 385                390                395                400
Ile Ala Leu Pro Ile Pro Ile Ile Val Asn Asn Phe Ser Glu Phe Tyr 
                 405                410                415
Lys Glu Gln Lys Arg Gln Glu Lys Ala Ile Lys Arg Arg Glu Ala Leu 
             420                425                430
Glu Arg Ala Lys Arg Asn Gly Ser Ile Val Ser Met Asn Met Lys Asp 
         435                440                445
Ala Phe Ala Arg Ser Ile Glu Met Met Asp Ile Val Val Glu Lys Asn 
     450                455                460
Gly Glu Ser Ile Ala Lys Lys Asp Lys Val Gln Asp Asn His Leu Ser 
 465                470                475                480
Pro Asn Lys Trp Lys Trp Thr Lys Arg Ala Leu Ser Glu Thr Ser Ser 
                 485                490                495
Ser Lys Ser Phe Glu Thr Lys Glu Gln Gly Ser Pro Glu Lys Ala Arg 
             500                505                510
Ser Ser Ser Ser Pro Gln His Leu Asn Val Gln Gln Leu Glu Asp Met 
         515                520                525
Tyr Ser Lys Met Ala Lys Thr Gln Ser Gln Pro Ile Leu Asn Thr Lys 
     530                535                540
Glu Met Ala Pro Gln Ser Lys Pro Pro Glu Glu Leu Glu Met Ser Ser 
 545                550                555                560
Met Pro Ser Pro Val Ala Pro Leu Pro Ala Arg Thr Glu Gly Val Ile 
                 565                570                575
Asp Met Arg Ser Met Ser Ser Ile Asp Ser Phe Ile Ser Cys Ala Thr 
             580                585                590
Asp Phe Pro Glu Ala Thr Arg Phe Ser His Ser Pro Leu Ala Ser Leu 
         595                600                605
Ser Ser Lys Ala Gly Ser Ser Thr Ala Pro Glu Val Gly Trp Arg Gly 
     610                615                620
Ala Leu Gly Ala Ser Gly Gly Arg Leu Thr Glu Thr Asn Pro Ile Pro 
 625                630                635                640
Glu Thr Ser Arg Ser Gly Phe Phe Val Glu Ser Pro Arg Ser Ser Met 
                 645                650                655
Lys Thr Asn Asn Pro Leu Lys Leu Arg Ala Leu Lys Val Asn Phe Val 
             660                665                670
Glu Gly Asp Pro Thr Pro Leu Leu Pro Ser Leu Gly Leu Tyr His Asp 
         675                680                685
Pro Leu Arg Asn Arg Gly Gly Ala Ala Ala Ala Val Ala Gly Leu Glu 
     690                695                700
Cys Ala Ser Leu Leu Asp Lys Pro Val Leu Ser Pro Glu Ser Ser Ile 
 705                710                715                720
Tyr Thr Thr Ala Ser Ala Arg Thr Pro Pro Arg Ser Pro Glu Lys His 
                 725                730                735
Thr Ala Ile Ala Phe Asn Phe Glu Ala Gly Val His His Tyr Ile Asp 
             740                745                750
Thr Asp Thr Asp Asp Glu Gly Gln Leu Leu Tyr Ser Val Asp Ser Ser 
         755                760                765
Pro Pro Lys Ser Leu His Gly Ser Thr Ser Pro Lys Phe Ser Thr Gly 
     770                775                780
Ala Arg Thr Glu Lys Asn His Phe Glu Ser Ser Pro Leu Pro Thr Ser 
 785                790                795                800
Pro Lys Phe Leu Arg Pro Asn Cys Val Tyr Ser Ser Glu Gly Leu Thr 
                 805                810                815
Gly Lys Gly Pro Gly Ala Gln Glu Lys Cys Lys Leu Glu Asn His Thr 
             820                825                830
Pro Pro Asp Val His Met Leu Pro Gly Gly Gly Ala His Gly Ser Thr 
         835                840                845
Arg Asp Gln Ser Ile 
     850



<210> 9483
<211> 936
<212> DNA
<213> Rattus norvegicus
<308> X16481
<400> 9483

gaattccgg  cgccgccac  gcgccaagt  ccggccgcg  ccaccttcc  ccgtccagg  60
ctcctccgc  tcggccccg  gaccccggc  ccccgccag  cccggcccc  gcaccatgt  120
ggagaagag  gtggaggca  cggccgagc  aagcgccaa  gacctgaag  aaaagaagg  180
caaggtgga  gagaaggct  gccggaaag  acggaagaa  gaagtagtg  aggaggagg  240
gaatggagc  gaggaggag  aagaagaaa  tgctgagga  ggagaggat  atgatgaag  300
agacgaaga  gatgaggag  aagaggagg  ggaggatga  ggccccgtg  ggaagagaa  360
tgctgaaga  gaggatgaa  cggatccca  gaggcagaa  acagaaaac  gggcgtcgg  420
ttgagcccc  gcccgtggg  ttggggatg  gaggcccct  aggtcctgg  ggtggggca  480
gaacacaca  atccagccc  ccttctcct  gctccctcg  ctggccctg  cccagagct  540
tgacccttg  cctttgacc  agcctctca  ttccatctc  ccagacact  ctccttcac  600
ctcactgcc  caggtccag  ccccaaccc  cctcatcca  gctccccag  cggccctca  660
ttgccctag  attccttgt  cttccctgc  ttcctcacc  tcgatctgt  ccagtcctt  720
cgaagcctc  ccttcccct  tgcaccccg  gcctctcag  ctgcccttc  ctctcctgc  780
tgacccctg  gtctccctc  gattccctc  tctcagaca  cgccaggcc  gggtggggc  840
ggggttggg  ccaagcccc  aagctgccc  ctccccttt  tgtataatt  aataaagaa  900
cggtcgcgc  tcaaaaaaa  aaaaaaaac  gaattc  936



<210> 9484
<211> 101
<212> PRT
<213> Rattus norvegicus
<308> P04550
<400> 9484

Ser Glu Lys Ser Val Glu Ala Ala Ala Glu Leu Ser Ala Lys Asp Leu 
  1               5                  10                  15
Lys Glu Lys Lys Asp Lys Val Glu Glu Lys Ala Gly Arg Lys Glu Arg 
             20                  25                  30
Lys Lys Glu Val Val Glu Glu Glu Glu Asn Gly Ala Glu Glu Glu Glu 
         35                  40                  45
Glu Glu Thr Ala Glu Asp Gly Glu Asp Asp Asp Glu Gly Asp Glu Glu 
     50                  55                  60
Asp Glu Glu Glu Glu Glu Glu Glu Asp Glu Gly Pro Val Arg Lys Arg 
 65                  70                  75                  80
Thr Ala Glu Glu Glu Asp Glu Ala Asp Pro Lys Arg Gln Lys Thr Glu 
                 85                  90                  95
Asn Gly Ala Ser Ala 
             100



<210> 9485
<211> 627
<212> DNA
<213> Rattus norvegicus
<308> X16933
<400> 9485

gagagtgta  ataaggtca  ggatcagaa  gaacataaa  tgaatggga  agtcattga  60
cctaaaagg  ccaaagcca  gaaaacaaa  gagcccgtc  aaaaaattt  tgttggtgg  120
ctttctcca  acacacctg  agaaaaaat  agagagtac  ttggtggtt  tggtgaggt  180
gaatccata  agctgccta  ggacaacaa  accaataag  ggcgtgggt  ctgtttcat  240
acctttaag  aagaggaac  agtgaagaa  ataatggag  agaaatacc  caatgttgg  300
cttagtaaa  gtgaaataa  agtagccat  tcgaaggag  agtatcagc  gcagcagca  360
tggggatct  gaggagggt  tgcaggaag  gctcgcgga  gaggcggtg  tcagcagag  420
ggttatggg  aagtatcca  acgaggtgg  catcaaaat  gctacaaac  atactaaat  480
attccactt  caacttatc  ccaacaggt  gtgaagcag  attttccaa  ttgaagatt  540
atttgaagt  gctcctgcc  cctgctaat  gcagttcaa  ctaaatttt  tctatcaag  600
tcccgaatg  aagtatgac  ttgggtg  627



<210> 9486
<211> 158
<212> PRT
<213> Rattus norvegicus
<308> CAA34808
<400> 9486

Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His Lys Leu Asn Gly 
  1               5                  10                  15
Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys Thr Lys Glu Pro 
             20                  25                  30
Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp Thr Pro Glu Glu 
         35                  40                  45
Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val Glu Ser Ile Glu 
     50                  55                  60
Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly Phe Cys Phe Ile 
 65                  70                  75                  80
Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met Glu Lys Lys Tyr 
                 85                  90                  95
His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val Ala Met Ser Lys 
             100                105                110
Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg Gly Gly Phe Ala 
         115                120                125
Gly Arg Ala Arg Gly Arg Gly Gly Asp Gln Gln Ser Gly Tyr Gly Lys 
     130                135                140
Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr Lys Pro Tyr 
 145                150                155



<210> 9487
<211> 1154
<212> DNA
<213> Homo sapiens
<308> M94630
<400> 9487

gaattcgag  atccgggta  catggcggc  ggcgagcag  agggagcca  ggtggcggc  60
acacagggg  cagcggcgg  ggcgggaag  ggaccggga  cgggggcgg  accgcgtct  120
gaggcaccg  agggcagcg  cgagtcgga  ggggcgaag  ttgacgcca  taagaacga  180
gaggatgaa  gccattcaa  ctcctcccc  cgacactct  aagcagcga  ggcacagcg  240
gaagaatgg  aaatgttta  aggaggcct  agctgggac  ctacaaaga  agatctgaa  300
gactacttt  ccaaatttg  tgaagttgt  gactgcact  tgaagttag  tcctatcac  360
gggcgatca  ggggttttg  ctttgtgct  tttaaagaa  cggagagtg  agataaggt  420
atggatcaa  aagaacata  attgaatgg  aaggtgatt  atcctaaaa  ggccaaagc  480
atgaaaaca  aagagccgg  taaaaaaat  tttgttggt  gcctttctc  agatacacc  540
gaagagaaa  taagggagt  ctttggtgg  tttggtgag  tggaatcca  agagctccc  600
atggacaac  agaccaata  gaggcgtgg  ttatgcttt  ttaccttta  ggaagaaga  660
ccagtgaag  agataatgg  aaagaaata  cacaatgtt  gtcttagta  atgtgaaat  720
aaagtagcc  tgtcgaagg  acaatatca  caacagcaa  agtggggat  tagaggagg  780
tttgcagga  gagctcgtg  aagaggtgg  gaccagcag  gtggttatg  gaaggtatc  840
agggcaggt  gtcatcaaa  tagctacaa  ccatatcta  attattcca  ttgcaactt  900
tccccaaca  gtggtgaag  agtattttc  aatttgaag  ttcatttga  tggctcctg  960
cacctgcta  tagcagttc  aactaaatt  tttgtatca  gtccctgaa  ggaagtatg  1020
cgttgggtc  ctctgaagt  taattctga  ttctcatta  aagaaattt  ctttcattg  1080
tttatttct  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  catggtacc  1140
ggatcctcg  attc  1154



<210> 9488
<211> 355
<212> PRT
<213> Homo sapiens
<308> Q14103
<400> 9488

Met Ser Glu Glu Gln Phe Gly Gly Asp Gly Ala Ala Ala Ala Ala Thr 
  1               5                  10                  15
Ala Ala Val Gly Gly Ser Ala Gly Glu Gln Glu Gly Ala Met Val Ala 
             20                  25                  30
Ala Thr Gln Gly Ala Ala Ala Ala Ala Gly Ser Gly Ala Gly Thr Gly 
         35                  40                  45
Gly Gly Thr Ala Ser Gly Gly Thr Glu Gly Gly Ser Ala Glu Ser Glu 
     50                  55                  60
Gly Ala Lys Ile Asp Ala Ser Lys Asn Glu Glu Asp Glu Gly His Ser 
 65                  70                  75                  80
Asn Ser Ser Pro Arg His Ser Glu Ala Ala Thr Ala Gln Arg Glu Glu 
                 85                  90                  95
Trp Lys Met Phe Ile Gly Gly Leu Ser Trp Asp Thr Thr Lys Lys Asp 
             100                105                110
Leu Lys Asp Tyr Phe Ser Lys Phe Gly Glu Val Val Asp Cys Thr Leu 
         115                120                125
Lys Leu Asp Pro Ile Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu 
     130                135                140
Phe Lys Glu Ser Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His 
 145                150                155                160
Lys Leu Asn Gly Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys 
                 165                170                175
Thr Lys Glu Pro Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp 
             180                185                190
Thr Pro Glu Glu Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val 
         195                200                205
Glu Ser Ile Glu Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly 
     210                215                220
Phe Cys Phe Ile Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met 
 225                230                235                240
Glu Lys Lys Tyr His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val 
                 245                250                255
Ala Met Ser Lys Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg 
             260                265                270
Gly Gly Phe Ala Gly Arg Ala Arg Gly Arg Gly Gly Gly Pro Ser Gln 
         275                280                285
Asn Trp Asn Gln Gly Tyr Ser Asn Tyr Trp Asn Gln Gly Tyr Gly Asn 
     290                295                300
Tyr Gly Tyr Asn Ser Gln Gly Tyr Gly Gly Tyr Gly Gly Tyr Asp Tyr 
 305                310                315                320
Thr Gly Tyr Asn Asn Tyr Tyr Gly Tyr Gly Asp Tyr Ser Asn Gln Gln 
                 325                330                335
Ser Gly Tyr Gly Lys Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr 
             340                345                350
Lys Pro Tyr 
         355



<210> 9489
<211> 627
<212> DNA
<213> Rattus norvegicus
<308> X16933
<400> 9489

gagagtgta  ataaggtca  ggatcagaa  gaacataaa  tgaatggga  agtcattga  60
cctaaaagg  ccaaagcca  gaaaacaaa  gagcccgtc  aaaaaattt  tgttggtgg  120
ctttctcca  acacacctg  agaaaaaat  agagagtac  ttggtggtt  tggtgaggt  180
gaatccata  agctgccta  ggacaacaa  accaataag  ggcgtgggt  ctgtttcat  240
acctttaag  aagaggaac  agtgaagaa  ataatggag  agaaatacc  caatgttgg  300
cttagtaaa  gtgaaataa  agtagccat  tcgaaggag  agtatcagc  gcagcagca  360
tggggatct  gaggagggt  tgcaggaag  gctcgcgga  gaggcggtg  tcagcagag  420
ggttatggg  aagtatcca  acgaggtgg  catcaaaat  gctacaaac  atactaaat  480
attccactt  caacttatc  ccaacaggt  gtgaagcag  attttccaa  ttgaagatt  540
atttgaagt  gctcctgcc  cctgctaat  gcagttcaa  ctaaatttt  tctatcaag  600
tcccgaatg  aagtatgac  ttgggtg  627



<210> 9490
<211> 158
<212> PRT
<213> Rattus norvegicus
<308> CAA34808
<400> 9490

Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His Lys Leu Asn Gly 
  1               5                  10                  15
Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys Thr Lys Glu Pro 
             20                  25                  30
Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp Thr Pro Glu Glu 
         35                  40                  45
Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val Glu Ser Ile Glu 
     50                  55                  60
Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly Phe Cys Phe Ile 
 65                  70                  75                  80
Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met Glu Lys Lys Tyr 
                 85                  90                  95
His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val Ala Met Ser Lys 
             100                105                110
Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg Gly Gly Phe Ala 
         115                120                125
Gly Arg Ala Arg Gly Arg Gly Gly Asp Gln Gln Ser Gly Tyr Gly Lys 
     130                135                140
Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr Lys Pro Tyr 
 145                150                155



<210> 9491
<211> 1154
<212> DNA
<213> Homo sapiens
<308> M94630
<400> 9491

gaattcgag  atccgggta  catggcggc  ggcgagcag  agggagcca  ggtggcggc  60
acacagggg  cagcggcgg  ggcgggaag  ggaccggga  cgggggcgg  accgcgtct  120
gaggcaccg  agggcagcg  cgagtcgga  ggggcgaag  ttgacgcca  taagaacga  180
gaggatgaa  gccattcaa  ctcctcccc  cgacactct  aagcagcga  ggcacagcg  240
gaagaatgg  aaatgttta  aggaggcct  agctgggac  ctacaaaga  agatctgaa  300
gactacttt  ccaaatttg  tgaagttgt  gactgcact  tgaagttag  tcctatcac  360
gggcgatca  ggggttttg  ctttgtgct  tttaaagaa  cggagagtg  agataaggt  420
atggatcaa  aagaacata  attgaatgg  aaggtgatt  atcctaaaa  ggccaaagc  480
atgaaaaca  aagagccgg  taaaaaaat  tttgttggt  gcctttctc  agatacacc  540
gaagagaaa  taagggagt  ctttggtgg  tttggtgag  tggaatcca  agagctccc  600
atggacaac  agaccaata  gaggcgtgg  ttatgcttt  ttaccttta  ggaagaaga  660
ccagtgaag  agataatgg  aaagaaata  cacaatgtt  gtcttagta  atgtgaaat  720
aaagtagcc  tgtcgaagg  acaatatca  caacagcaa  agtggggat  tagaggagg  780
tttgcagga  gagctcgtg  aagaggtgg  gaccagcag  gtggttatg  gaaggtatc  840
agggcaggt  gtcatcaaa  tagctacaa  ccatatcta  attattcca  ttgcaactt  900
tccccaaca  gtggtgaag  agtattttc  aatttgaag  ttcatttga  tggctcctg  960
cacctgcta  tagcagttc  aactaaatt  tttgtatca  gtccctgaa  ggaagtatg  1020
cgttgggtc  ctctgaagt  taattctga  ttctcatta  aagaaattt  ctttcattg  1080
tttatttct  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  catggtacc  1140
ggatcctcg  attc  1154



<210> 9492
<211> 355
<212> PRT
<213> Homo sapiens
<308> Q14103
<400> 9492

Met Ser Glu Glu Gln Phe Gly Gly Asp Gly Ala Ala Ala Ala Ala Thr 
  1               5                  10                  15
Ala Ala Val Gly Gly Ser Ala Gly Glu Gln Glu Gly Ala Met Val Ala 
             20                  25                  30
Ala Thr Gln Gly Ala Ala Ala Ala Ala Gly Ser Gly Ala Gly Thr Gly 
         35                  40                  45
Gly Gly Thr Ala Ser Gly Gly Thr Glu Gly Gly Ser Ala Glu Ser Glu 
     50                  55                  60
Gly Ala Lys Ile Asp Ala Ser Lys Asn Glu Glu Asp Glu Gly His Ser 
 65                  70                  75                  80
Asn Ser Ser Pro Arg His Ser Glu Ala Ala Thr Ala Gln Arg Glu Glu 
                 85                  90                  95
Trp Lys Met Phe Ile Gly Gly Leu Ser Trp Asp Thr Thr Lys Lys Asp 
             100                105                110
Leu Lys Asp Tyr Phe Ser Lys Phe Gly Glu Val Val Asp Cys Thr Leu 
         115                120                125
Lys Leu Asp Pro Ile Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu 
     130                135                140
Phe Lys Glu Ser Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His 
 145                150                155                160
Lys Leu Asn Gly Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys 
                 165                170                175
Thr Lys Glu Pro Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp 
             180                185                190
Thr Pro Glu Glu Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val 
         195                200                205
Glu Ser Ile Glu Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly 
     210                215                220
Phe Cys Phe Ile Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met 
 225                230                235                240
Glu Lys Lys Tyr His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val 
                 245                250                255
Ala Met Ser Lys Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg 
             260                265                270
Gly Gly Phe Ala Gly Arg Ala Arg Gly Arg Gly Gly Gly Pro Ser Gln 
         275                280                285
Asn Trp Asn Gln Gly Tyr Ser Asn Tyr Trp Asn Gln Gly Tyr Gly Asn 
     290                295                300
Tyr Gly Tyr Asn Ser Gln Gly Tyr Gly Gly Tyr Gly Gly Tyr Asp Tyr 
 305                310                315                320
Thr Gly Tyr Asn Asn Tyr Tyr Gly Tyr Gly Asp Tyr Ser Asn Gln Gln 
                 325                330                335
Ser Gly Tyr Gly Lys Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr 
             340                345                350
Lys Pro Tyr 
         355



<210> 9493
<211> 2573
<212> DNA
<213> Rattus norvegicus
<308> X17163
<400> 9493

gacgactgg  ctgcgccgc  ggagaacct  tgtcgctgg  gctggtccg  gggctccga  60
gaaccgctg  ttcctgaga  cgctccgtg  gtgaccgcg  cttttcaaa  ctccggatc  120
cgcgggacc  accaacgtg  gtgcaagcg  tgtcttaac  ctgcgctcc  tggagcgaa  180
tggggagga  ggcgcaggg  ggagcactg  ggtctggag  gcacgctcc  aaacaaact  240
tgttactga  gcggggacg  gcgggtatc  cccgcttcc  ggcgcgctg  tgcggcccc  300
aaacttctg  gcacagccc  ggctaaccc  gcgtgaagt  accgactgt  ctatgactg  360
aaagatgga  acgaccttc  acgacgatg  cctcaacgc  tcgttcctc  agtccgaga  420
tggcgccta  ggctacagt  accctaaga  tctgaagca  agcatgacc  tgaacctgg  480
cgacccggt  ggcaatctg  agccgcacc  ccgagccaa  aactcggac  ttctcacgt  540
gcccgacgt  gggctgctc  agctggcgt  gccggagct  gagcgcctg  tcatccagt  600
cagcaatgg  cacatcacc  ctacaccga  ccccactca  ttcttgtgc  ccaagaacg  660
gaccgacga  caggagggc  tcgccgaag  cttcgtgcg  gccctagct  aactgcata  720
ccagaatac  ctgcccagt  tcacctccg  ggcacaacc  gtcagtggg  cgggcatgg  780
cgctcccgc  gtggcctca  tagctggcg  tggcggcgg  ggcggctac  gcgccagcc  840
gcacagtga  cctccggtc  acgccaacc  cagcaactt  aacccgggt  cgctgagca  900
cggcggtgg  gcgccctcc  atggcgcga  cgggctggc  tttccatcg  agccccagc  960
gcagcagca  ccgcctcag  cgccgcacc  cttgcccca  cagatcccg  tgcagcacc  1020
gcggctgca  gcgctgaag  aagagccgc  gacggtgcc  gagatgccg  gagagacgc  1080
gcccttgtc  cccatcgac  tggagtctc  ggagcggat  aaggcggag  ggaagcgca  1140
gagaaaccg  atcgctgcc  ccaagtgcc  gaaaaggaa  ctggagcgg  tcgcccggc  1200
agaggaaaa  gtgaaaacc  tgaaagcgc  aaactccga  ctggcgtcc  cggccaaca  1260
gctcaggga  caggtggca  agcttaaac  gaaagtcat  aaccacgtt  acagtgggt  1320
ccaactcat  ctaacgcag  agttgcaaa  gttttgagg  cagactgtc  gggctgagg  1380
gcagtggaa  aaaaaaata  cagagataa  cttgagaac  tgactggtt  cgacagaga  1440
aaaaaagtg  ccgagtact  aagccaagg  tacacaaga  ggactgggt  gcgacctga  1500
ggcgccccc  atgtgctgg  gtgggaagg  cgtggcgcg  ctggctttg  cgaggagcc  1560
gagagcagc  gcctgttcg  gacgctttg  gaacgggct  tgccgcgac  agaacgatg  1620
acttttcgt  aacattgac  aagaactgc  tggacctaa  attcgatct  attcagtat  1680
aaggggggt  ggtgggggc  tacaaactg  aatagagac  gtagattgc  tctctagtg  1740
tccgtaaga  cacaaagca  ggagggctg  gaaggggag  gaggcttgt  agtaccagg  1800
tagattgcg  atgaactcc  ctggcctgc  tctctcaac  gtgtatgta  atatatttt  1860
ttttaattt  atgaaagct  attactgtc  ataataaac  gcttcctgc  tttgtaagt  1920
atttcatgt  tgtttgttt  ggtgtccta  ccagtgttt  taaataaga  atttgaagc  1980
ttctgagtt  accatttgt  ataaagtat  taatttttt  atgttttgt  tctgaaaat  2040
tccagaaag  atatttaag  aaacacaat  aaccattga  aagtagccc  caacctctc  2100
gctgcatta  cgatagata  tgagagcta  gtgaaatga  agctgagtg  ctgtatgct  2160
gggtgagag  ctgtagtcc  tcccgtctg  ttgtaggaa  agacaccct  catgctatc  2220
ttgactcat  ctctctccc  agcaaccca  aagtccaga  tgttgacca  aagatggtg  2280
agtgtttct  aaggctgga  gaagagggt  ttgcaaggg  agagggaca  cccactggg  2340
aagcagatg  ttgagttga  agccatatc  agtagcatg  gctgtgatc  tttataata  2400
taataaaga  ttcagcaat  agatgttta  ctcaaagca  ggacccatg  aaggtttta  2460
aaaaggtgt  tccttccaa  ttggattct  acgactcct  gaaaaagat  acctttgct  2520
gtgcatatt  ataatagtt  gtatcacaa  aaatgtatt  aaataatgg  ttt  2573



<210> 9494
<211> 334
<212> PRT
<213> Rattus norvegicus
<308> CAA35084
<400> 9494

Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
  1               5                  10                  15
Ser Phe Leu Gln Ser Glu Ser Gly Ala Tyr Gly Tyr Ser Asn Pro Lys 
             20                  25                  30
Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Asn 
         35                  40                  45
Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
     50                  55                  60
Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
 65                  70                  75                  80
Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                 85                  90                  95
Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
             100                105                110
Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
         115                120                125
Ser Val Thr Ser Ala Ala Gln Pro Val Ser Gly Ala Gly Met Val Ala 
     130                135                140
Pro Ala Val Ala Ser Val Ala Gly Ala Gly Gly Gly Gly Gly Tyr Ser 
 145                150                155                160
Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                 165                170                175
Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
             180                185                190
Thr Gly Leu Ala Phe Pro Ser Gln Pro Gln Gln Gln Gln Gln Pro Pro 
         195                200                205
Gln Pro Pro His His Leu Pro Gln Gln Ile Pro Val Gln His Pro Arg 
     210                215                220
Leu Gln Ala Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly 
 225                230                235                240
Glu Thr Pro Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile 
                 245                250                255
Lys Ala Glu Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys 
             260                265                270
Arg Lys Arg Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys 
         275                280                285
Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu 
     290                295                300
Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn 
 305                310                315                320
Ser Gly Cys Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe 
                 325                330



<210> 9495
<211> 3622
<212> DNA
<213> Homo sapiens
<308> J04111
<400> 9495

cccggggag  ggaccgggg  acagagggc  gagaggcgt  cggcagggg  gagggtagg  60
gaaagaagg  cccgactgt  ggagggcag  ggagcatta  ctcatcccg  gagcctccg  120
gggcccaga  aagaatctt  tagggtgga  tctccatgg  gacgggcgg  cccgccccc  180
tgagagcga  gcgagccaa  gggaaggcc  tggggtgac  tcatgggct  tttttaggg  240
ttgactggt  gcagataag  gttgagctc  ggctggata  gggctcaga  ttgcactga  300
tgtggctga  gcagcgagg  gggagtgga  gtgcgcgga  tcaggcaga  agacagaca  360
agccagcca  ccaggtcgg  agtatagtc  gaactgcaa  tcttatttt  ttttcacct  420
ctctctaac  gcccagagc  agcgcctgt  gctcccggg  tggtggttc  ggagtgtcc  480
gagagcctt  tctccagcc  gccccggga  gagagccct  ctgcccagg  gctgttgac  540
gcggcggaa  gcagcggta  cccacgcgc  cgccggggg  cgtcggcga  cggctgcag  600
agcaaagaa  tttcccggc  gggaggacc  gagacaagt  gcagagtcc  ggagcgaac  660
tttgcaagc  tttcctgcg  cttaggctt  tccacggcg  taaagacca  aaggcggcg  720
agagccacg  aagagaaga  ggacgtgcg  tcagcttcg  tcgcaccgg  tgttgaact  780
gggcgagcg  gagccgcgg  tgccgggcg  cccctcccc  tagcagcgg  ggaggggac  840
agtcgtcgg  gtccgggcg  ccaagaccc  ccgccggcc  gccactgca  ggtccgcac  900
gatccgctc  gcggggaga  ccgctgctc  gggaagtga  ttcgcctgc  gactccgag  960
aaccgctgc  cccgaagag  gctcagtga  tgaccgcga  ttttcaaag  cgggtagcg  1020
gcgcgagtc  acaagtaag  gtgcgggag  catcttaat  aaccctgcg  tccctggag  1080
gagctggtg  ggagggcgc  gcggggacg  cagccagcg  gtgcgtgcg  tcttagaga  1140
actttccct  tcaaaggct  cggggggcg  gggtgtccc  cgcttgcca  agccctgtt  1200
cggccccga  acttgtgcg  gcacgccaa  ctaacctca  gtgaagtga  ggactgttc  1260
atgactgca  agatggaaa  gaccttcta  gacgatgcc  tcaacgcct  gttcctccc  1320
tccgagagc  gaccttatg  ctacagtaa  cccaagatc  tgaaacaga  catgaccct  1380
aacctggcc  acccagtgg  gagcctgaa  ccgcacctc  gcgccaaga  ctcggacct  1440
ctcacctcg  ccgacgtgg  gctgctcaa  ctggcgtcg  ccgagctgg  gcgcctgat  1500
atccagtcc  gcaacgggc  catcaccac  acgccgacc  ccacccagt  cctgtgccc  1560
aagaacgtg  cagatgagc  ggaggggtt  gccgagggc  tcgtgcgcg  cctggccga  1620
ctgcacagc  agaacacgc  gcccagcgt  acgtcggcg  cgcagccgg  caacggggc  1680
ggcatggtg  ctcccgcgg  agcctcggt  gcagggggc  gcggcagcg  cggcttcag  1740
gccagcctg  acagcgagc  gccggtcta  gcaaacctc  gcaacttca  cccaggcgc  1800
ctgagcagc  gcggcgggg  gccctccta  ggcgcggcc  gcctggcct  tcccgcgca  1860
ccccagcag  agcagcagc  gccgcacca  ctgccccag  agatgcccg  gcagcaccc  1920
cggctgcag  ccctgaagg  ggagcctca  acagtgccc  agatgcccg  cgagacacc  1980
cccctgtcc  ccatcgaca  ggagtccca  gagcggatc  aggcggaga  gaagcgcat  2040
aggaaccgc  tcgctgcct  caagtgccg  aaaaggaag  tggagagaa  cgcccggct  2100
gaggaaaaa  tgaaaacct  gaaagctca  aactcggag  tggcgtcca  ggccaacat  2160
ctcagggaa  aggtggcac  gcttaaaca  aaagtcatg  accacgtta  cagtgggtg  2220
caactcatg  taacgcagc  gttgcaaac  ttttgaaga  agaccgtcg  gggctgagg  2280
gcaacgaag  aaaaaaata  cacagagag  cagacttga  aacttgaca  gttgcgacg  2340
agagaaaaa  gaagtgtcc  agaactaaa  ccaagggta  ccaagttgg  ctgggttcg  2400
tctgacggc  cccccagtg  gcacgagtg  gaaggactt  gtcgcgccc  cccttggcg  2460
ggagccagg  agcggccgc  tgcgggctg  cccgctttg  ggacgggct  tccccgcgc  2520
aacggaacg  tggactttc  ttaacattg  ccaagaact  catggacct  acattcgat  2580
tcattcagt  ttaaagggg  gagggggag  gggttacaa  ctgcaatag  gactgtaga  2640
tgcttctgt  gtactcctt  agaacacaa  gcgggggga  ggttgggga  gggcggcag  2700
agggaggtt  gtgagagcg  ggctgagcc  acagatgaa  tctttctgg  ctgctttcg  2760
taactgtgt  tgtacatat  tatattttt  aatttgatt  aagctgatt  ctgtcaata  2820
acagcttca  gcctttgta  gttatttct  gtttgtttg  ttgggtatc  tgcccagtg  2880
tgtttgtaa  taagagatt  ggagcactc  gagtttacc  tttgtaata  agtatataa  2940
ttttttatg  tttgtttct  aaaattcca  aaaggatat  taagaaaat  caataaact  3000
ttggaaagt  ctcccctaa  ctcttttct  catcatctg  agatcctag  ctatctagg  3060
ggagttgaa  gagttaaga  tgctcgata  aatcactct  agtgcttct  actattaag  3120
agtaaaaac  gttctctat  agacttaga  ataaatgta  ctgatgtac  tgatgctat  3180
tcaggcttc  tactccacg  tcccccagc  tatctatat  gaattgctt  ccaaaggct  3240
gtgcgatgt  tcaggaggc  ggaggaagg  gggttgcag  ggagaggga  agcccactg  3300
gaagtcaaa  atttcaaag  ttggattgc  tcaagtggc  tgtgctgtg  ccatttata  3360
tgttagaaa  tttacaata  gtgcttatt  tcaaagcag  aattggtgg  agattttac  3420
aaagatgta  ccttccaat  tggaatctt  tctttgaca  ttcctagat  aaaagatgg  3480
ctttgtctt  tgaatattt  taacagcat  ctgtcacaa  aaatgtatt  aaataccaa  3540
aacagatct  gaattgctt  cctttacta  ttttttgtt  ccaagttat  tactgaagt  3600
tttattttt  gttgctgag  tt  3622



<210> 9496
<211> 331
<212> PRT
<213> Homo sapiens
<308> AAA59197
<400> 9496

Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
  1               5                  10                  15
Ser Phe Leu Pro Ser Glu Ser Gly Pro Tyr Gly Tyr Ser Asn Pro Lys 
             20                  25                  30
Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser 
         35                  40                  45
Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
     50                  55                  60
Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
 65                  70                  75                  80
Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                 85                  90                  95
Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
             100                105                110
Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
         115                120                125
Ser Val Thr Ser Ala Ala Gln Pro Val Asn Gly Ala Gly Met Val Ala 
     130                135                140
Pro Ala Val Ala Ser Val Ala Gly Gly Ser Gly Ser Gly Gly Phe Ser 
 145                150                155                160
Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                 165                170                175
Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
             180                185                190
Ala Gly Leu Ala Phe Pro Ala Gln Pro Gln Gln Gln Gln Gln Pro Pro 
         195                200                205
His His Leu Pro Gln Gln Met Pro Val Gln His Pro Arg Leu Gln Ala 
     210                215                220
Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly Glu Thr Pro 
 225                230                235                240
Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile Lys Ala Glu 
                 245                250                255
Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg 
             260                265                270
Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys 
         275                280                285
Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln 
     290                295                300
Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn Ser Gly Cys 
 305                310                315                320
Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe 
                 325                330



<210> 9497
<211> 2573
<212> DNA
<213> Rattus norvegicus
<308> X17163
<400> 9497

gacgactgg  ctgcgccgc  ggagaacct  tgtcgctgg  gctggtccg  gggctccga  60
gaaccgctg  ttcctgaga  cgctccgtg  gtgaccgcg  cttttcaaa  ctccggatc  120
cgcgggacc  accaacgtg  gtgcaagcg  tgtcttaac  ctgcgctcc  tggagcgaa  180
tggggagga  ggcgcaggg  ggagcactg  ggtctggag  gcacgctcc  aaacaaact  240
tgttactga  gcggggacg  gcgggtatc  cccgcttcc  ggcgcgctg  tgcggcccc  300
aaacttctg  gcacagccc  ggctaaccc  gcgtgaagt  accgactgt  ctatgactg  360
aaagatgga  acgaccttc  acgacgatg  cctcaacgc  tcgttcctc  agtccgaga  420
tggcgccta  ggctacagt  accctaaga  tctgaagca  agcatgacc  tgaacctgg  480
cgacccggt  ggcaatctg  agccgcacc  ccgagccaa  aactcggac  ttctcacgt  540
gcccgacgt  gggctgctc  agctggcgt  gccggagct  gagcgcctg  tcatccagt  600
cagcaatgg  cacatcacc  ctacaccga  ccccactca  ttcttgtgc  ccaagaacg  660
gaccgacga  caggagggc  tcgccgaag  cttcgtgcg  gccctagct  aactgcata  720
ccagaatac  ctgcccagt  tcacctccg  ggcacaacc  gtcagtggg  cgggcatgg  780
cgctcccgc  gtggcctca  tagctggcg  tggcggcgg  ggcggctac  gcgccagcc  840
gcacagtga  cctccggtc  acgccaacc  cagcaactt  aacccgggt  cgctgagca  900
cggcggtgg  gcgccctcc  atggcgcga  cgggctggc  tttccatcg  agccccagc  960
gcagcagca  ccgcctcag  cgccgcacc  cttgcccca  cagatcccg  tgcagcacc  1020
gcggctgca  gcgctgaag  aagagccgc  gacggtgcc  gagatgccg  gagagacgc  1080
gcccttgtc  cccatcgac  tggagtctc  ggagcggat  aaggcggag  ggaagcgca  1140
gagaaaccg  atcgctgcc  ccaagtgcc  gaaaaggaa  ctggagcgg  tcgcccggc  1200
agaggaaaa  gtgaaaacc  tgaaagcgc  aaactccga  ctggcgtcc  cggccaaca  1260
gctcaggga  caggtggca  agcttaaac  gaaagtcat  aaccacgtt  acagtgggt  1320
ccaactcat  ctaacgcag  agttgcaaa  gttttgagg  cagactgtc  gggctgagg  1380
gcagtggaa  aaaaaaata  cagagataa  cttgagaac  tgactggtt  cgacagaga  1440
aaaaaagtg  ccgagtact  aagccaagg  tacacaaga  ggactgggt  gcgacctga  1500
ggcgccccc  atgtgctgg  gtgggaagg  cgtggcgcg  ctggctttg  cgaggagcc  1560
gagagcagc  gcctgttcg  gacgctttg  gaacgggct  tgccgcgac  agaacgatg  1620
acttttcgt  aacattgac  aagaactgc  tggacctaa  attcgatct  attcagtat  1680
aaggggggt  ggtgggggc  tacaaactg  aatagagac  gtagattgc  tctctagtg  1740
tccgtaaga  cacaaagca  ggagggctg  gaaggggag  gaggcttgt  agtaccagg  1800
tagattgcg  atgaactcc  ctggcctgc  tctctcaac  gtgtatgta  atatatttt  1860
ttttaattt  atgaaagct  attactgtc  ataataaac  gcttcctgc  tttgtaagt  1920
atttcatgt  tgtttgttt  ggtgtccta  ccagtgttt  taaataaga  atttgaagc  1980
ttctgagtt  accatttgt  ataaagtat  taatttttt  atgttttgt  tctgaaaat  2040
tccagaaag  atatttaag  aaacacaat  aaccattga  aagtagccc  caacctctc  2100
gctgcatta  cgatagata  tgagagcta  gtgaaatga  agctgagtg  ctgtatgct  2160
gggtgagag  ctgtagtcc  tcccgtctg  ttgtaggaa  agacaccct  catgctatc  2220
ttgactcat  ctctctccc  agcaaccca  aagtccaga  tgttgacca  aagatggtg  2280
agtgtttct  aaggctgga  gaagagggt  ttgcaaggg  agagggaca  cccactggg  2340
aagcagatg  ttgagttga  agccatatc  agtagcatg  gctgtgatc  tttataata  2400
taataaaga  ttcagcaat  agatgttta  ctcaaagca  ggacccatg  aaggtttta  2460
aaaaggtgt  tccttccaa  ttggattct  acgactcct  gaaaaagat  acctttgct  2520
gtgcatatt  ataatagtt  gtatcacaa  aaatgtatt  aaataatgg  ttt  2573



<210> 9498
<211> 334
<212> PRT
<213> Rattus norvegicus
<308> CAA35041
<400> 9498

Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
  1               5                  10                  15
Ser Phe Leu Gln Ser Glu Ser Gly Ala Tyr Gly Tyr Ser Asn Pro Lys 
             20                  25                  30
Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Asn 
         35                  40                  45
Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
     50                  55                  60
Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
 65                  70                  75                  80
Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                 85                  90                  95
Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
             100                105                110
Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
         115                120                125
Ser Val Thr Ser Ala Ala Gln Pro Val Ser Gly Ala Gly Met Val Ala 
     130                135                140
Pro Ala Val Ala Ser Val Ala Gly Ala Gly Gly Gly Gly Gly Tyr Ser 
 145                150                155                160
Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                 165                170                175
Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
             180                185                190
Thr Gly Leu Ala Phe Pro Ser Gln Pro Gln Gln Gln Gln Gln Pro Pro 
         195                200                205
Gln Pro Pro His His Leu Pro Gln Gln Ile Pro Val Gln His Pro Arg 
     210                215                220
Leu Gln Ala Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly 
 225                230                235                240
Glu Thr Pro Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile 
                 245                250                255
Lys Ala Glu Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys 
             260                265                270
Arg Lys Arg Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys 
         275                280                285
Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu 
     290                295                300
Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn 
 305                310                315                320
Ser Gly Cys Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe 
                 325                330



<210> 9499
<211> 3321
<212> DNA
<213> Homo sapiens
<308> XM_001472
<400> 9499

gacatcatg  gctattttt  ggggttgac  ggtagcaga  aagtgttga  ctcgggctg  60
ataagggct  agagttgca  tgagtgtgg  tgaagcagc  aggcgggag  ggaggtgcg  120
ggagtcagg  agacagaca  acacagcca  ccagccagg  cggcagtat  gtccgaact  180
caaatctta  tttcttttc  ccttctctc  aactgccca  agctagcgc  tgtggctcc  240
gggctggtg  ttcgggagt  tccagagag  ctggtctcc  gccgccccc  ggaggagag  300
cctgctgcc  aggcgctgt  gacagcggc  gaaagcagc  gtacccacg  gcccgccgg  360
ggaagtcgg  gagcggctg  agcagcaaa  aactttccc  gctgggagg  ccggagaca  420
gtggcagag  cccggagcc  acttttgca  gcctttcct  cgtcttagg  ttctccacg  480
cggtaaaga  cagaaggcg  cggagagcc  cgcaagaga  gaaggacgt  cgctcagct  540
cgctcgcac  ggttgttga  cttgggcga  cgcgagccg  ggctgccgg  cgccccctc  600
ccctagcag  ggaggaggg  acaagtcgt  ggagtccgg  cggccaaga  ccgccgccg  660
ccggccact  cagggtccg  actgatccg  tccgcgggg  gagccgctg  tctgggaag  720
gagttcgcc  gcggactcc  aggaaccgc  gcgcacgaa  agcgctcag  gagtgaccg  780
gacttttca  agccgggta  cgcgcgcga  tcgacaagt  agagtgcgg  aggcatctt  840
attaaccct  cgctccctg  agcgagctg  tgaggaggg  gcagcgggg  cgacagcca  900
cgggtgcgt  cgctcttag  gaaactttc  ctgtcaaag  ctccggggg  cgcgggtgt  960
ccccgcttg  cacagccct  ttgcggccc  gaaacttgt  cgcgcagcc  aaactaacc  1020
cacgtgaag  gacggactg  tctatgact  caaagatgg  aacgacctt  tatgacgat  1080
ccctcaacg  ctcgttcct  ccgtccgag  gcggacctt  tggctacag  aaccccaag  1140
tcctgaaac  gagcatgac  ctgaacctg  ccgacccag  ggggagcct  aagccgcac  1200
tccgcgcca  gaactcgga  ctcctcacc  cgcccgacg  ggggctgct  aagctggcg  1260
cgcccgagc  ggagcgcct  ataatccag  ccagcaacg  gcacatcac  accacgccg  1320
cccccaccc  gttcctgtg  cccaagaac  tgacagatg  gcaggaggg  ttcgccgag  1380
gcttcgtgc  cgccctggc  gaactgcac  gccagaaca  gctgcccag  gtcacgtcg  1440
cggcgcagc  ggtcaacgg  gcaggcatg  tggctcccg  ggtagcctc  gtggcaggg  1500
gcagcggca  cggcggctt  agcgccagc  tgcacagcg  gccgccggt  tacgcaaac  1560
tcagcaact  caacccagg  gcgctgagc  gcggcggcg  ggcgccctc  tacggcgcg  1620
ccggcctgg  ctttcccgc  caaccccag  agcagcagc  gccgccgca  cacctgccc  1680
agcagatgc  cgtgcagca  ccgcggctg  aggccctga  ggaggagcc  cagacagtg  1740
ccgagatgc  cggcgagac  ccgcccctg  cccccatcg  catggagtc  caggagcgg  1800
tcaaggcgg  gaggaagcg  atgaggaac  gcatcgctg  ctccaagtg  cgaaaaagg  1860
agctggaga  aatcgcccg  ctggaggaa  aagtgaaaa  cttgaaagc  cagaactcg  1920
agctggcgt  cacggccaa  atgctcagg  aacaggtgg  acagcttaa  cagaaagtc  1980
tgaaccacg  taacagtgg  tgccaactc  tgctaacgc  gcagttgca  acattttga  2040
gagagaccg  cgggggctg  ggggcaacg  agaaaaaaa  taacacaga  agacagact  2100
gagaacttg  caagttgcg  cggagagaa  aaagaagtg  ccgagaact  aagccaagg  2160
tatccaagt  ggactgggt  gcgtcctga  ggcgccccc  gtgtgcacg  gtgggaagg  2220
cttggcgcg  cctcccttg  cgtggagcc  gggagcggc  gcctgcggg  tgccccgct  2280
tgcggacgg  ctgtccccg  gcgaacgga  cgttggact  ttcgttaac  ttgaccaag  2340
actgcatgg  cctaacatt  gatctcatt  agtattaaa  gggggaggg  gagggggtt  2400
caaactgca  tagagactg  agattgctt  tgtagtact  cttaagaac  caaagcggg  2460
ggagggttg  ggaggggcg  caggaggga  gtttgtgag  gcgaggctg  gcctacaga  2520
gaactcttt  tggcctgcc  tcgttaact  tgtatgtac  tatatatat  ttttaattt  2580
atgaaagct  attactgtc  ataaacagc  tcatgcctt  gtaagttat  tcttgtttg  2640
ttgtttggg  atcctgccc  gtgttgttt  taaataaga  atttggagc  ctctgagtt  2700
accatttgt  ataaagtat  taatttttt  atgttttgt  tctgaaaat  ccagaaagg  2760
tatttaaga  aatacaata  actattgga  agtactccc  taacctctt  tctgcatca  2820
ctgtagata  tagctatct  ggtggagtt  aaagagtta  gaatgtcga  taaaatcac  2880
ctcagtgct  cttactatt  agcagtaaa  actgttctc  attagactt  agaaataaa  2940
gtacctgat  tacctgatg  tatggtcag  ttatactcc  cctccccca  ctatctata  3000
ggaattgct  accaaagga  agtgcgatg  ttcaggagg  tggaggaag  ggggttgca  3060
tggagaggg  cagcccact  agaagtcaa  catttcaaa  tttggattg  atcaagtgg  3120
atgtgctgt  accatttat  atgttagta  aaattttac  ataggtgct  attctcaaa  3180
caggaattg  tggcagatt  tacaaaaga  gtatccttc  aatttggaa  cttctcttt  3240
acaattcct  gataaaaag  tggcctttg  ttatgaata  ttataacag  attcttgtc  3300
caataaatg  attcaaata  c  3321



<210> 9500
<211> 331
<212> PRT
<213> Homo sapiens
<308> XP_001472
<400> 9500

Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
  1               5                  10                  15
Ser Phe Leu Pro Ser Glu Ser Gly Pro Tyr Gly Tyr Ser Asn Pro Lys 
             20                  25                  30
Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser 
         35                  40                  45
Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
     50                  55                  60
Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
 65                  70                  75                  80
Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                 85                  90                  95
Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
             100                105                110
Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
         115                120                125
Ser Val Thr Ser Ala Ala Gln Pro Val Asn Gly Ala Gly Met Val Ala 
     130                135                140
Pro Ala Val Ala Ser Val Ala Gly Gly Ser Gly Ser Gly Gly Phe Ser 
 145                150                155                160
Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                 165                170                175
Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
             180                185                190
Ala Gly Leu Ala Phe Pro Ala Gln Pro Gln Gln Gln Gln Gln Pro Pro 
         195                200                205
His His Leu Pro Gln Gln Met Pro Val Gln His Pro Arg Leu Gln Ala 
     210                215                220
Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly Glu Thr Pro 
 225                230                235                240
Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile Lys Ala Glu 
                 245                250                255
Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg 
             260                265                270
Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys 
         275                280                285
Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln 
     290                295                300
Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn Ser Gly Cys 
 305                310                315                320
Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe 
                 325                330



<210> 9501
<211> 3330
<212> DNA
<213> Rattus norvegicus
<308> X51529
<400> 9501

tgtgatgga  tgaatgact  acacgtgaa  taagcagcg  acagaacca  cgttccctt  60
cctatcccc  aaagtyaca  tttatcaga  gaaagaaac  tcccagact  tcaaacact  120
attccctcc  ctgtataca  tccttccat  ctcctggaa  tggctgcca  gaggctgca  180
gcggtcaca  ccagatggg  ttttggaaa  ttctccagt  aggagctgc  ccctgtttc  240
catcaaccg  atgaacttt  gaaatcagc  aaagtttat  atggccaca  cccatggta  300
gagggcttt  ccggccctc  aggctgttc  gccagctgt  ggggggaaa  ggggaaatt  360
cccagggcg  tgggtatgc  cgtctgtga  tccattatt  ggccacacc  acctcccca  420
ccctgtggc  ctccgatcc  cagccctgc  gagggaaga  ctatttaag  gcattggga  480
tacaggaaa  acaaggcag  cccttgaac  agaagccat  ccaccatcc  atccaagag  540
tacatgccc  gaaactcct  ccctttgga  gcatttgag  gattgtgca  gtgagcatg  600
gtgtgtgta  ggacgtgcc  gtggatgtg  attcccatc  ggtaaacat  tacaagacc  660
cattcctgg  caagtatct  atatgggat  gtgagagtg  tgggggaga  tttgagaat  720
tgtgtgttt  catgtcatc  gtcgtgggt  agaaaggag  catcatatg  ataaatatg  780
aatcgtcac  ggcttacaa  ggcagcatg  gtgcatgtc  tttgcatag  gttagaata  840
aaaggcatc  tgtatgtat  cacgtagtg  gcagagtca  aaaggcttg  aaagagaat  900
tgcagtttt  gttggagag  agactgtca  gatcggacc  tgtggatgg  attcctaag  960
cttgaatct  acttgagga  gtaggtgaa  tatatagtg  aggcagaca  tgccttcaa  1020
ccctccacc  caattctgc  gaacgagtc  caggaggac  agaggaagt  caggggtgg  1080
cccatcacc  catcattcc  gtgtgaggg  cagttccac  gagccagga  ggacaagag  1140
tgacattcg  aatgcacgg  cggaagcca  tctgtgtgt  ctctgtgac  tagccccat  1200
caagtgcac  tctgtgctc  gggattgct  agtcagaca  ctgagcagg  gctgggtaa  1260
gggtaagct  tcctggaag  aagtgacca  gctgtgtgt  cctgtcctt  acagagctg  1320
cagcatgaa  gtcctcctg  tgctagcag  tgtgatcat  gcctttggt  agagtggac  1380
ctgaactca  cacaatgag  gaggtaacc  gaggaggga  gcaccctat  ccctggctt  1440
ccttcctgt  ggcctggcc  tctcttagt  tgaggagga  gaagccatt  gtggggaga  1500
aaagtagca  agagatgcc  tgtggagtt  gggcacaga  gttcaccac  cttgaccag  1560
ttatttccc  atttccttt  aggctcaat  caggtccag  ggagccttc  ggagtttgg  1620
caaatgatt  tgtttaaga  aggaaagag  gctgatgtt  gctatggct  ctacggttg  1680
cattgtggt  tgggtggca  aggatcccc  aaggatgcc  cagattggt  agaccaccc  1740
agtccccct  tcctctgtc  ctccagctg  acgggacta  gagggagct  gtactcact  1800
cctcagtgt  ccaccgaat  ccagccagc  gatgttagc  gattgggag  tctgccctg  1860
accactcta  agttcttga  tctctgctc  gaaccaaag  tcaaaggaa  tgctggggt  1920
ccaggactc  agggccgtg  gaaggcagc  tcagtaagg  ctgtcctcc  accaggtgc  1980
gtgtgactc  tgactgttg  tacaaccgt  tggagaaac  tggatgtgg  acaaagttt  2040
tgacctaca  gttctccta  cgagggggc  aaatctcct  ctctagtaa  ataccctga  2100
atacctgcc  gctttcttc  cgggggtgt  gagcacaca  atgcatgct  ggaacttta  2160
tggtgcagg  ttacttaca  aagcaggcc  gttagcagg  cagcagggc  aaagatgta  2220
ctcagctgg  tgggtgcta  cctagcata  gtgagggcc  gggttccac  ctcagcagt  2280
tatgaaatg  acaaaattt  gcatgacct  aatcccagt  ctcatgtgc  ggcaggagg  2340
tcagaagtt  aaggccatc  tcagctact  agagaactc  aaggcagcc  aagctataa  2400
gaccctgtc  cctcacccc  cgtccctcg  ccctcgctc  tcccccttc  ccctctccc  2460
cccctcccc  ccaaaaaaa  cctagaaga  ggtggctag  gatcgaggc  aacctctgg  2520
agcgccatg  gtggccact  tgtgtcccc  tcagatggt  agatggggt  ctgccttcc  2580
aggaagcag  cagttcccc  cgagcagcc  tgagacagt  gccatcagc  ctgtgtccg  2640
ttcccccta  ttgcagcaa  ccaggactc  tgccggaaa  agctgtgcc  gtgcgataa  2700
gctgccgct  aatgttttg  ccggaacaa  aaaagctac  gtttaaagt  ccagttcta  2760
ctcaacaag  tttgcaaag  gaagacgcc  agttgctga  agagccatc  tctgaaaca  2820
ccagacatc  tctaacacc  ctcctagcc  aaccaagtt  cccagtgat  aagaaaaca  2880
ccctctcca  ccctagaag  aggcgggcc  ttctgtctt  acccagaag  agccgctga  2940
gcctgatct  tccccaaca  tccacagcc  tggatccgc  cactttcac  tttcccttg  3000
catccaact  cctgctgcg  agtacctaa  agagtcctg  gaggctctc  caagtaaag  3060
aattcatca  caaccacgt  tgtgttctc  taactcgaa  cgagacaga  ataaaatat  3120
catgctcaa  gtataggcc  tgaggctgg  gaggtggct  agtccataa  gtgcttgcc  3180
aaaaaaaaa  aaaacaaaa  aaacaaaaa  acgagggcc  atgttcaac  cccagaacc  3240
agggacatc  agggcattc  tgtttgcaa  cctagagtt  gggaaagaa  gaaagtgga  3300
ccctggggc  caatggcca  ccaggctagc  3330



<210> 9502
<211> 146
<212> PRT
<213> Rattus norvegicus
<308> CAA35909
<400> 9502

Met Lys Val Leu Leu Leu Leu Ala Val Val Ile Met Ala Phe Gly Ser 
  1               5                  10                  15
Ile Gln Val Gln Gly Ser Leu Leu Glu Phe Gly Gln Met Ile Leu Phe 
             20                  25                  30
Lys Thr Gly Lys Arg Ala Asp Val Ser Tyr Gly Phe Tyr Gly Cys His 
         35                  40                  45
Cys Gly Val Gly Gly Arg Gly Ser Pro Lys Asp Ala Thr Asp Trp Cys 
     50                  55                  60
Cys Val Thr His Asp Cys Cys Tyr Asn Arg Leu Glu Lys Arg Gly Cys 
 65                  70                  75                  80
Gly Thr Lys Phe Leu Thr Tyr Lys Phe Ser Tyr Arg Gly Gly Gln Ile 
                 85                  90                  95
Ser Cys Ser Thr Asn Gln Asp Ser Cys Arg Lys Gln Leu Cys Gln Cys 
             100                105                110
Asp Lys Ala Ala Ala Glu Cys Phe Ala Arg Asn Lys Lys Ser Tyr Ser 
         115                120                125
Leu Lys Tyr Gln Phe Tyr Pro Asn Lys Phe Cys Lys Gly Lys Thr Pro 
     130                135                140
Ser Cys 
 145



<210> 9503
<211> 997
<212> DNA
<213> Homo sapiens
<308> NM_000300
<400> 9503

gaaggaaaa  gagcaacag  tccagggag  attcacctg  cctgtctcc  aacagcctt  60
tgcctcacc  acccccaac  tcccagagg  agcagctat  taaggggag  aggagtgca  120
aacaaacaa  acggcctgg  gatacaact  tggagtcct  tgagagagc  accaaggag  180
agcagggga  cgacggccg  ggcagaagt  gagaccacc  agcagagga  ctaggccag  240
ccatctgca  ttgtcaccc  agaactctt  ccatgaaga  cctcctact  ttggcagtg  300
tcatgatct  tggcctact  caggcccat  ggaatttgg  gaatttcca  agaatgatc  360
agttgacga  aggaaagga  gccgcactc  gttatggct  ctacggctg  cactgtggc  420
tgggtggca  aggatcccc  aaggatgca  cggatcgct  ctgtgtcac  catgactgt  480
gctacaaac  tctggagaa  cgtggatgt  gcaccaaat  tctgagcta  aagtttagc  540
actcgggga  cagaatcac  tgtgcaaaa  aggactcct  cagaagtca  ctgtgtgag  600
gtgataagg  tgctgccac  tgttttgct  gaaacaaga  gacctacaa  aaaaagtac  660
agtactatt  caataaaca  tgcagaggg  gcacccctc  ttgctgagt  ccctcttcc  720
tggaaacct  ccacccagt  ctgaatttc  ctctctcat  ccctccctc  ctaccctaa  780
caagttcct  ggccatgca  aaagcatcc  tcacccatc  tagaggcca  gcaggagcc  840
ttctatacc  acccagaat  agacatcca  cagatttcc  gccttctac  gctctcctc  900
acctcaact  cgtgcttaa  caaagaagc  gtactccgg  gggtctctt  tgaataaag  960
aattagcaa  aaaaaaaaa  aaaaaaaaa  aaaaaaa  997



<210> 9504
<211> 144
<212> PRT
<213> Homo sapiens
<308> P14555
<400> 9504

Met Lys Thr Leu Leu Leu Leu Ala Val Ile Met Ile Phe Gly Leu Leu 
  1               5                  10                  15
Gln Ala His Gly Asn Leu Val Asn Phe His Arg Met Ile Lys Leu Thr 
             20                  25                  30
Thr Gly Lys Glu Ala Ala Leu Ser Tyr Gly Phe Tyr Gly Cys His Cys 
         35                  40                  45
Gly Val Gly Gly Arg Gly Ser Pro Lys Asp Ala Thr Asp Arg Cys Cys 
     50                  55                  60
Val Thr His Asp Cys Cys Tyr Lys Arg Leu Glu Lys Arg Gly Cys Gly 
 65                  70                  75                  80
Thr Lys Phe Leu Ser Tyr Lys Phe Ser Asn Ser Gly Ser Arg Ile Thr 
                 85                  90                  95
Cys Ala Lys Gln Asp Ser Cys Arg Ser Gln Leu Cys Glu Cys Asp Lys 
             100                105                110
Ala Ala Ala Thr Cys Phe Ala Arg Asn Lys Thr Thr Tyr Asn Lys Lys 
         115                120                125
Tyr Gln Tyr Tyr Ser Asn Lys His Cys Arg Gly Ser Thr Pro Arg Cys 
     130                135                140



<210> 9505
<211> 2376
<212> DNA
<213> Rattus norvegicus
<308> X51615
<400> 9505

cgcggccgt  cgctctccc  actcgcagc  agtcggcgc  tcccgccta  tgagcgcag  60
ctccaccag  atccgcggg  accagctcg  gatcagccg  cgacccact  ctgaccaac  120
caggagcgg  ccgataccc  ctcccgacc  acccgcgac  gacccaggg  cccactccg  180
acctgctcc  tacagggga  agcgcctcg  cgcttcccg  cgcccagcg  ccgcacgct  240
ctcgggaca  agtgccaac  atccagagg  caagatgga  tggggcaca  tacagagca  300
cctcggggg  gtcaacaag  actccacca  cattgggaa  atctggctc  ctgtcctct  360
catcttccg  atcatgatc  tcgtggtgg  cgcgaagga  gtgtgggga  atgagcaag  420
cgattttgt  tgcaacact  tccagcctg  ctgtaagaa  gtgtgctac  accactact  480
ccccatctc  cacatccgg  tctgggctc  gcagctgat  atggtgtcc  cgccggccc  540
cctggtagc  atgcacgtg  cctaccgga  acacgaaaa  aaacggaag  tcatgaagg  600
agagataaa  aacgagttt  aggacatcg  agagatcaa  acccagaag  tccgtatcg  660
agggtccct  tggtggacc  acaccacca  catcttctt  cgggtcatc  tcgaagctg  720
cttcatgta  gtcttttac  tcatgtaca  tggcttctt  atgcagcgt  tggtgaagt  780
taacgcctg  ccttgtccc  atacagtgg  ctgcttcat  tccaggccc  cagaaaaga  840
tgtcttcac  gtgttcatg  tctctgtgt  tggaatttg  atcctgcta  acatcacag  900
gctgtgcta  ctgttcatt  ggtattgct  agggaagtc  aaaagacca  tctaatgca  960
tgcctggct  ttaagcaaa  atgagggag  ggatgaggc  acctgtgct  agttatcag  1020
gttcagcta  cagcatctc  cgggcaaac  ttcccacct  aaatgccgc  atttgaagt  1080
ccccgcagg  ctcccatga  actccagaa  cctccatgg  cctcccttc  cccaaagct  1140
ccaaacaaa  gcccaattc  atgcctgta  taatgggtt  taaagttag  tagaccccg  1200
gctggtgtg  ctatgcttt  ggatacatt  acagtttaa  caaagggat  tcacattgt  1260
tctcttcct  tgaggacag  agacatgag  ccagtcctg  ggaaggtac  gagaaagtt  1320
cttcttccg  gtccccttc  ccaagttgc  cccagttaa  ggtaaagaa  cttcgttct  1380
ttattttct  tcatagttt  agtttgcaa  aatggacaa  agctattta  tgttcaagc  1440
agctgtgtc  ttttttttt  ttttaaatg  aaaccttaa  atgataggt  cttttgttc  1500
taaaatgat  tggaaagca  tatacattc  tcctatttc  gaggttcgg  ttgtgatgt  1560
agcatggtg  ataaccaga  ctcacaagg  ctttaaaac  ttggccttt  ggttatggg  1620
aacctgggc  gtggctgag  gcccaccta  tgtattcat  cttaggtgt  ctgagtaca  1680
cccgcaaca  cgttacagc  tgtctcaaa  gagacaaac  ggaagcttc  cgtgttagc  1740
tctgacaag  agaggcctt  attaaaatt  tcaaccgta  ttttgtgta  gaggcagat  1800
ggttatgcc  acaactgcc  cctgccatg  gcctaactc  gcccccctc  acccccagc  1860
cgtctactc  gtagctgtg  gatgtggca  tcagtatca  aagacttca  gagtttgct  1920
gggaatttc  ctgccatgg  acaatttaa  ggtgcagaa  caagatggg  tggttttca  1980
agaaccgat  aaacttcta  actctaaat  ctgttgatt  aaactgagt  tttctactt  2040
gaatgtctg  ttgcctccc  tttcagcat  gccttctaa  ctggaaaca  aaatgttga  2100
atttggaaa  aatagaaga  actagttta  gtcaatgtg  aacttttct  ggacaagtt  2160
aaccttagc  ttgtcattc  gcctgatgt  ttgtccaca  gatgacagt  aacaaatcc  2220
acaggggac  cttcttcct  ccaagaatg  cgttgggaa  ccattctgt  acaataaat  2280
agagttgtg  tttaaagtc  acactattt  acctaatga  gaacttatt  ctgatgttc  2340
gaaattcga  attgaaagg  gttttgcca  tacggg  2376



<210> 9506
<211> 261
<212> PRT
<213> Rattus norvegicus
<308> AAD50911
<400> 9506

Met Asp Trp Gly Thr Leu His Thr Val Ile Gly Gly Val Asn Lys His 
  1               5                  10                  15
Ser Thr Ser Ile Gly Lys Val Trp Ile Thr Val Ile Phe Ile Phe Arg 
             20                  25                  30
Val Met Ile Leu Val Val Ala Ala Gln Glu Val Trp Gly Asp Glu Gln 
         35                  40                  45
Glu Asp Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Lys Asn Val Cys 
     50                  55                  60
Tyr Asp His Phe Phe Pro Val Ser His Ile Arg Leu Trp Ala Leu Gln 
 65                  70                  75                  80
Leu Thr Phe Val Ser Thr Ser Ala Leu Leu Val Ala Met His Val Ala 
                 85                  90                  95
Tyr Tyr Arg His Glu Thr Ala Arg Lys Phe Ile Arg Gly Glu Lys Arg 
             100                105                110
Asn Glu Phe Lys Asp Leu Glu Asp Ile Lys Arg Gln Lys Val Arg Ile 
         115                120                125
Glu Gly Ser Leu Trp Trp Thr Tyr Thr Ser Ser Ile Phe Phe Arg Ile 
     130                135                140
Ile Phe Glu Ala Ala Phe Met Tyr Val Phe Tyr Phe Leu Tyr Asn Gly 
 145                150                155                160
Tyr His Leu Pro Trp Val Leu Lys Cys Gly Ile Asp Pro Cys Pro Asn 
                 165                170                175
Leu Val Asp Cys Phe Ile Ser Arg Pro Thr Glu Lys Thr Val Phe Thr 
             180                185                190
Val Phe Met Ile Ser Ala Ser Val Ile Cys Met Leu Leu Asn Val Ala 
         195                200                205
Glu Leu Cys Tyr Leu Leu Leu Lys Leu Cys Phe Arg Arg Ser Lys Arg 
     210                215                220
Thr Gln Ala Gln Arg Asn His Pro Asn His Ala Leu Lys Glu Ser Lys 
 225                230                235                240
Gln Asn Glu Met Asn Glu Leu Ile Ser Asp Ser Gly Gln Asn Ala Ile 
                 245                250                255
Thr Ser Phe Pro Ser 
             260



<210> 9507
<211> 671
<212> DNA
<213> Rattus norvegicus
<308> X51706
<400> 9507

ccgagaatg  agaccattc  cagcaatca  actgtcgac  ttccagaaa  tgtcgacat  60
actctgaag  ggcgcacag  cattgtgaa  ggccccaga  gaactctga  gagggactt  120
aatcacatc  atgtagagc  gagtcttct  ggaaagaaa  agaaaaggc  ccgtgttga  180
aagtggtgg  gtaacagga  ggaactggc  actgtcaga  ccatctgca  tcatgttca  240
aacatgatc  agggtgtga  actgggctt  cgttacaag  tgaggtctg  gtatgctca  300
ttccctatc  acgtcgtta  tcaggagaa  gggtctctg  ttgaaatcc  aaatttctt  360
ggtgaaaaa  acatccgga  ggttcggat  aggacaggt  ttgcttgtt  tgtctctca  420
gcccagaag  atgagttaa  ccttgaagg  aatgatatt  aacttgttt  aaattcagc  480
gctctgatt  agcaagcca  aacagttaa  aacaaggat  tcaggaagt  tttggatgg  540
atctatgtt  ctgagaagg  aaccgtcca  cagcctgac  aatgagacc  cagtttcct  600
gcttcagaa  caagatcct  ataacaagt  cagtttggg  tctgtggaa  caataaaag  660
cttatatat  g  671



<210> 9508
<211> 192
<212> PRT
<213> Rattus norvegicus
<308> CAA36002
<400> 9508

Met Lys Thr Ile Leu Ser Asn Gln Thr Val Asp Ile Pro Glu Asn Val 
  1               5                  10                  15
Asp Ile Thr Leu Lys Gly Arg Thr Val Ile Val Lys Gly Pro Arg Gly 
             20                  25                  30
Thr Leu Arg Arg Asp Phe Asn His Ile Asn Val Glu Leu Ser Leu Leu 
         35                  40                  45
Gly Lys Lys Lys Lys Arg Leu Arg Val Asp Lys Trp Trp Gly Asn Arg 
     50                  55                  60
Lys Glu Leu Ala Thr Val Arg Thr Ile Cys Ser His Val Gln Asn Met 
 65                  70                  75                  80
Ile Lys Gly Val Thr Leu Gly Phe Arg Tyr Lys Met Arg Ser Val Tyr 
                 85                  90                  95
Ala His Phe Pro Ile Asn Val Val Ile Gln Glu Asn Gly Ser Leu Val 
             100                105                110
Glu Ile Arg Asn Phe Leu Gly Glu Lys Tyr Ile Arg Arg Val Arg Met 
         115                120                125
Arg Thr Gly Val Ala Cys Ser Val Ser Gln Ala Gln Lys Asp Glu Leu 
     130                135                140
Ile Leu Glu Gly Asn Asp Ile Glu Leu Val Ser Asn Ser Ala Ala Leu 
 145                150                155                160
Ile Gln Gln Ala Thr Thr Val Lys Asn Lys Asp Ile Arg Lys Phe Leu 
                 165                170                175
Asp Gly Ile Tyr Val Ser Glu Lys Gly Thr Val Gln Gln Pro Asp Glu 
             180                185                190



<210> 9509
<211> 671
<212> DNA
<213> Rattus norvegicus
<308> X51706
<400> 9509

ccgagaatg  agaccattc  cagcaatca  actgtcgac  ttccagaaa  tgtcgacat  60
actctgaag  ggcgcacag  cattgtgaa  ggccccaga  gaactctga  gagggactt  120
aatcacatc  atgtagagc  gagtcttct  ggaaagaaa  agaaaaggc  ccgtgttga  180
aagtggtgg  gtaacagga  ggaactggc  actgtcaga  ccatctgca  tcatgttca  240
aacatgatc  agggtgtga  actgggctt  cgttacaag  tgaggtctg  gtatgctca  300
ttccctatc  acgtcgtta  tcaggagaa  gggtctctg  ttgaaatcc  aaatttctt  360
ggtgaaaaa  acatccgga  ggttcggat  aggacaggt  ttgcttgtt  tgtctctca  420
gcccagaag  atgagttaa  ccttgaagg  aatgatatt  aacttgttt  aaattcagc  480
gctctgatt  agcaagcca  aacagttaa  aacaaggat  tcaggaagt  tttggatgg  540
atctatgtt  ctgagaagg  aaccgtcca  cagcctgac  aatgagacc  cagtttcct  600
gcttcagaa  caagatcct  ataacaagt  cagtttggg  tctgtggaa  caataaaag  660
cttatatat  g  671



<210> 9510
<211> 192
<212> PRT
<213> Rattus norvegicus
<308> CAA36002
<400> 9510

Met Lys Thr Ile Leu Ser Asn Gln Thr Val Asp Ile Pro Glu Asn Val 
  1               5                  10                  15
Asp Ile Thr Leu Lys Gly Arg Thr Val Ile Val Lys Gly Pro Arg Gly 
             20                  25                  30
Thr Leu Arg Arg Asp Phe Asn His Ile Asn Val Glu Leu Ser Leu Leu 
         35                  40                  45
Gly Lys Lys Lys Lys Arg Leu Arg Val Asp Lys Trp Trp Gly Asn Arg 
     50                  55                  60
Lys Glu Leu Ala Thr Val Arg Thr Ile Cys Ser His Val Gln Asn Met 
 65                  70                  75                  80
Ile Lys Gly Val Thr Leu Gly Phe Arg Tyr Lys Met Arg Ser Val Tyr 
                 85                  90                  95
Ala His Phe Pro Ile Asn Val Val Ile Gln Glu Asn Gly Ser Leu Val 
             100                105                110
Glu Ile Arg Asn Phe Leu Gly Glu Lys Tyr Ile Arg Arg Val Arg Met 
         115                120                125
Arg Thr Gly Val Ala Cys Ser Val Ser Gln Ala Gln Lys Asp Glu Leu 
     130                135                140
Ile Leu Glu Gly Asn Asp Ile Glu Leu Val Ser Asn Ser Ala Ala Leu 
 145                150                155                160
Ile Gln Gln Ala Thr Thr Val Lys Asn Lys Asp Ile Arg Lys Phe Leu 
                 165                170                175
Asp Gly Ile Tyr Val Ser Glu Lys Gly Thr Val Gln Gln Pro Asp Glu 
             180                185                190



<210> 9511
<211> 3987
<212> DNA
<213> Rattus norvegicus
<308> X52140
<400> 9511

agtatggag  gaaggtcgt  taaaaaggc  gatgtccct  taaggtttg  tttgctgct  60
cccgtggac  ttagcctaa  cagggtccc  cgaagttgg  tttatttgt  catgtctcg  120
acacagcct  ggtagctgc  agtgagatt  cagggacgg  gcgcgcaaa  gggggggaa  180
tgtggcaat  catctggga  gtgagacgc  tggagaggg  ttagcagca  ttgaccaaa  240
cacaggaaa  cactcctcc  cagctcctg  gcgcagcag  ggctggggc  actgccgga  300
accctcgga  accacacga  tgacccaga  cgcaagtcg  cagcgtccc  gttctgcct  360
ttcctgcca  ctcctgccc  cgaaccggc  cgtagctgg  tccagcagc  gctccagca  420
tggtcccca  gcgtcctgc  agcctagag  tcactgtag  ctgcatatg  cttctcacg  480
tcatcctag  cttctgcgt  tccttcaat  ttgatgtga  aaactcaat  agtttcagt  540
gcccagtag  ggacatgtt  ggatacact  ttcaacaat  tgaaaacga  gaaggcaaa  600
gggttctta  tggttctcc  ttagttggc  aacccaaag  aagaactgg  gatgtctat  660
agtgtccgg  tgggagaga  agagcaatg  cttgcgtga  gttggactt  ccagttaac  720
catcgatcc  caatgtcac  gaaataaag  aaaacatga  atttggatc  actttagtc  780
ccaacccga  tggaggatt  ctggcatgt  ggcccttgt  tgcctatag  tgtggacat  840
tgcattata  aactggaat  tgttctgat  tcagtccta  atttcaagt  gtgaactcc  900
ttgcccctg  acaagaatg  agcacccag  tggacatag  catcgtcct  gatggctcc  960
acagcatct  cccctggga  agtgtcatc  cctttttaa  cgaccttct  aagaggatg  1020
atattggcc  taagcagac  caggtcggg  ttgtacagt  tggagagaa  gtaacccat  1080
agttcaacc  caataagta  tcatccaca  aagaggtcc  tgtcgcagc  aacaaaata  1140
gccgacagg  aggcctcca  acgatgaca  cccttggaa  agacacagc  aggaaagag  1200
cattcactg  agctcgggg  gccaggagg  gagttaaaa  agtcatggt  attgtgacc  1260
acggagaat  gcatgacaa  tatcgcctg  aacaggtca  ccaagactg  gaggacgaa  1320
acattcagc  attttccat  gctatcctt  gccactata  cagggggaa  ttaagcact  1380
aaaaatttg  ggaggaaat  aaatcgatc  caagcgagc  cacggaaaa  cacttcttc  1440
atgtctcgg  tgagttggc  ctggtcact  ttgttaaag  tctgggaga  aggatattc  1500
ctttggaag  gacagctga  cagtcagca  cttcatttg  gatggaaat  tctcagact  1560
gcttcagtg  tcactactc  caggactgg  tcatgcttg  agcggtggg  gcctatgac  1620
ggaacggaa  tgtggtcat  cagaaggct  accagatgg  catccctca  aacaccacc  1680
ttcaaactg  gcccgccaa  atgaacgag  ctctggctt  ttatttagg  tacacagtg  1740
actcggcca  catccctgg  gatgtgctc  acatcgctg  gcagcctcg  tacaatcat  1800
cgggccagg  cgtcatcta  aagatggag  atgggaaca  caacattct  cagacactc  1860
gcggagagc  gattggttc  tactttggt  gtgtcttaa  aacaattga  atcgacaaa  1920
attcttata  tgatctgct  ctcgtcggg  cccccatgt  catggggac  gagaaagag  1980
aacagggca  ggtgtacgt  tacgctgtg  atcagacaa  gtttgaata  caaatgagc  2040
tggaaccaa  taggcagac  tgctgctca  ccctgaagg  taattcatg  acgaaagaa  2100
acaagaatg  gccctgcgg  gcccgcttc  gaacagcaa  tgctgctgt  aaagacctc  2160
acgtggatg  atttaatga  gtcgtgatt  gagctccgc  ggaagatga  cacgcagga  2220
ctgtgtaca  ttatcatgg  agtggcaag  ccataaggg  ggcgtatgc  caacgcatt  2280
catcaggtg  ggatggcaa  accctgaaa  ttttcggcc  gtctatcca  ggagagatg  2340
atttaaatg  tgacggtct  actgacgtg  ccattggag  ccttggtgg  gcagccctc  2400
tctgggcca  agatgtggc  gtagttaaa  tgaccatga  ttttgaacc  aataaagtg  2460
atattcaaa  gaaaaactg  cgtgtggag  gcaaagaaa  agtgtgcat  aatgctaca  2520
tgtgttttc  tgtgaaatt  aagtctaaa  aggactcaa  ttacgaggc  gatctgcag  2580
accgtgtca  ccttgattc  ctgaggcag  tatcacgga  ctttttttc  ggaactcag  2640
aaaggaaga  tcaaagaaa  atcaccgtt  gagaatcag  atgcatcag  cactccttc  2700
acatgttgg  caaacatga  tttcaggac  ctgtgagag  gactctgga  tttaatctc  2760
ctgatccag  aaatggtcc  gtacttgat  acgctctgc  aaactcagt  cacgaacac  2820
ttccctttg  caaagactg  ggaaacaag  aaagatgca  ttcagacct  actctgaat  2880
tgtccacca  agaaaagag  ctgctgatc  tcaagtccc  gcatgacaa  ttcaacgtt  2940
gcctcaccg  caaaaacaa  ggagacagt  cgtacaaca  caggacagt  gtgcagcat  3000
caccaaatc  gattttttc  ggaattgag  agatccaaa  agatagctg  gaatctaat  3060
aaaatatca  ttgcagagt  ggatatcct  tcctaagag  aggagaaac  gttaccttc  3120
aaataatat  ccagtttaa  acatcccat  tctcggaaa  tgcaatcat  cacttaagt  3180
caacaagtg  cagtgagga  cccctggaa  ctcttaatg  taatgaagt  aatatttcc  3240
tcccagtaa  atatgaagt  ggactgcag  tttacagtt  tgcgagtga  catcacatt  3300
cagtcgctg  caatgagac  atccctgag  ttattaact  cactgagga  attgggaat  3360
aaattaatg  cttctatac  attagaaag  gggggcatt  cccaatgcc  gaacttcag  3420
tgtcaattt  attccccaa  ttgacggca  atggttatc  tgtactgta  ccaattgga  3480
ggtcatctt  agataatgt  aactgtaga  cccggagcc  tgaggaccc  tttggcatc  3540
actctggga  gaaaatgac  atatcgaag  ctgaggttc  caaaagagg  acaatccag  3600
actgcagta  tacgtgtgg  gttgccacc  tcacgtgta  cctccttcc  tccgacctg  3660
gtcaagtga  tgtctcgct  ctcctgtgg  aaccgactt  cataagagc  catttttcc  3720
gcttaaacc  tactctaag  ggagaactt  agagtgaaa  ttcatcgct  actttaagt  3780
gcagcaacc  gaagcgaga  ctggctatt  agatatcca  agacgggct  ccaggcaga  3840
tgccgctgt  ggttatcct  ctgagcgcc  tcgcggggc  actgctgct  atgctcctt  3900
tattggctc  gtggaagat  ggattcttc  aaaggccac  gaagaagaa  atggagaaa  3960
gaaaggttt  atagaaaaa  aaaaaaa  3987



<210> 9512
<211> 1180
<212> PRT
<213> Rattus norvegicus
<308> P18614
<400> 9512

Met Val Pro Arg Arg Pro Ala Ser Leu Glu Val Thr Val Ala Cys Ile 
  1               5                  10                  15
Trp Leu Leu Thr Val Ile Leu Gly Phe Cys Val Ser Phe Asn Val Asp 
             20                  25                  30
Val Lys Asn Ser Met Ser Phe Ser Gly Pro Val Glu Asp Met Phe Gly 
         35                  40                  45
Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile 
     50                  55                  60
Gly Ser Pro Leu Val Gly Gln Pro Lys Ala Arg Thr Gly Asp Val Tyr 
 65                  70                  75                  80
Lys Cys Pro Val Gly Arg Glu Arg Ala Met Pro Cys Val Lys Leu Asp 
                 85                  90                  95
Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Ile Lys Glu Asn 
             100                105                110
Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Asn Gly Gly Phe Leu 
         115                120                125
Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr 
     130                135                140
Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser 
 145                150                155                160
Phe Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val 
                 165                170                175
Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Glu Ser Val Ile Ala Phe 
             180                185                190
Leu Asn Asp Leu Leu Lys Arg Met Asp Ile Gly Pro Lys Gln Thr Gln 
         195                200                205
Val Gly Ile Val Gln Tyr Gly Glu Asn Val Thr His Glu Phe Asn Leu 
     210                215                220
Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Asn Lys Ile 
 225                230                235                240
Gly Arg Gln Gly Gly Leu Gln Thr Met Thr Ala Leu Gly Ile Asp Thr 
                 245                250                255
Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val 
             260                265                270
Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn Tyr 
         275                280                285
Arg Leu Lys Gln Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg 
     290                295                300
Phe Ser Ile Ala Ile Leu Gly His Tyr Asn Arg Gly Asn Leu Ser Thr 
 305                310                315                320
Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu 
                 325                330                335
Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val 
             340                345                350
Lys Ala Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln 
         355                360                365
Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala 
     370                375                380
His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp 
 385                390                395                400
Trp Asn Gly Thr Val Val Met Gln Lys Ala Asn Gln Met Val Ile Pro 
                 405                410                415
His Asn Thr Thr Phe Gln Thr Glu Pro Ala Lys Met Asn Glu Pro Leu 
             420                425                430
Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ile Pro Gly Asp 
         435                440                445
Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln Val 
     450                455                460
Val Ile Tyr Lys Met Glu Asp Gly Asn Ile Asn Ile Leu Gln Thr Leu 
 465                470                475                480
Gly Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Thr Thr Ile 
                 485                490                495
Asp Ile Asp Lys Asp Ser Tyr Thr Asp Leu Leu Leu Val Gly Ala Pro 
             500                505                510
Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val Tyr 
         515                520                525
Ala Val Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro Ile 
     530                535                540
Arg Gln Thr Cys Cys Ser Ser Leu Lys Asp Asn Ser Cys Thr Lys Glu 
 545                550                555                560
Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Ile Ala Ala 
                 565                570                575
Val Lys Asp Leu Asn Val Asp Gly Phe Asn Asp Val Val Ile Gly Ala 
             580                585                590
Pro Leu Glu Asp Asp His Ala Gly Ala Val Tyr Ile Tyr His Gly Ser 
         595                600                605
Gly Lys Thr Ile Arg Glu Ala Tyr Ala Gln Arg Ile Pro Ser Gly Gly 
     610                615                620
Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu Met 
 625                630                635                640
Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu Gly 
                 645                650                655
Gly Ala Ala Leu Phe Trp Ala Arg Asp Val Ala Val Val Lys Val Thr 
             660                665                670
Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys Arg 
         675                680                685
Val Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Met Cys Phe His 
     690                695                700
Val Lys Leu Lys Ser Lys Glu Asp Ser Ile Tyr Glu Ala Asp Leu Gln 
 705                710                715                720
Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe Phe 
                 725                730                735
Ser Gly Thr Gln Glu Arg Lys Ile Gln Arg Asn Ile Thr Val Arg Glu 
             740                745                750
Ser Glu Cys Ile Arg His Ser Phe Tyr Met Leu Asp Lys His Asp Phe 
         755                760                765
Gln Asp Ser Val Arg Val Thr Leu Asp Phe Asn Leu Thr Asp Pro Glu 
     770                775                780
Asn Gly Pro Val Leu Asp Asp Ala Leu Pro Asn Ser Val His Glu His 
 785                790                795                800
Ile Pro Phe Ala Lys Asp Cys Gly Asn Lys Glu Arg Cys Ile Ser Asp 
                 805                810                815
Leu Thr Leu Asn Val Ser Thr Thr Glu Lys Ser Leu Leu Ile Val Lys 
             820                825                830
Ser Gln His Asp Lys Phe Asn Val Ser Leu Thr Val Lys Asn Lys Gly 
         835                840                845
Asp Ser Ala Tyr Asn Thr Arg Thr Val Val Gln His Ser Pro Asn Leu 
     850                855                860
Ile Phe Ser Gly Ile Glu Glu Ile Gln Lys Asp Ser Cys Glu Ser Asn 
 865                870                875                880
Gln Asn Ile Thr Cys Arg Val Gly Tyr Pro Phe Leu Arg Ala Gly Glu 
                 885                890                895
Thr Val Thr Phe Lys Ile Ile Phe Gln Phe Asn Thr Ser His Leu Ser 
             900                905                910
Glu Asn Ala Ile Ile His Leu Ser Ala Thr Ser Asp Ser Glu Glu Pro 
         915                920                925
Leu Glu Ser Leu Asn Asp Asn Glu Val Asn Ile Ser Ile Pro Val Lys 
     930                935                940
Tyr Glu Val Gly Leu Gln Phe Tyr Ser Ser Ala Ser Glu His His Ile 
 945                950                955                960
Ser Val Ala Ala Asn Glu Thr Ile Pro Glu Phe Ile Asn Ser Thr Glu 
                 965                970                975
Asp Ile Gly Asn Glu Ile Asn Val Phe Tyr Thr Ile Arg Lys Arg Gly 
             980                985                990
His Phe Pro Met Pro Glu Leu Gln Leu Ser Ile Ser Phe Pro Asn Leu 
         995                1000                1005
Thr Ala Asp Gly Tyr Pro Val Leu Tyr Pro Ile Gly Trp Ser Ser Ser 
     1010                1015                1020
Asp Asn Val Asn Cys Arg Pro Arg Ser Leu Glu Asp Pro Phe Gly Ile 
 1025                1030                1035                1040
Asn Ser Gly Lys Lys Met Thr Ile Ser Lys Ser Glu Val Leu Lys Arg 
                 1045                1050                1055
Gly Thr Ile Gln Asp Cys Ser Ser Thr Cys Gly Val Ala Thr Ile Thr 
             1060                1065                1070
Cys Ser Leu Leu Pro Ser Asp Leu Ser Gln Val Asn Val Ser Leu Leu 
         1075                1080                1085
Leu Trp Lys Pro Thr Phe Ile Arg Ala His Phe Ser Ser Leu Asn Leu 
     1090                1095                1100
Thr Leu Arg Gly Glu Leu Lys Ser Glu Asn Ser Ser Leu Thr Leu Ser 
 1105                1110                1115                1120
Ser Ser Asn Arg Lys Arg Glu Leu Ala Ile Gln Ile Ser Lys Asp Gly 
                 1125                1130                1135
Leu Pro Gly Arg Val Pro Leu Trp Val Ile Leu Leu Ser Ala Phe Ala 
             1140                1145                1150
Gly Leu Leu Leu Leu Met Leu Leu Ile Leu Ala Leu Trp Lys Ile Gly 
         1155                1160                1165
Phe Phe Lys Arg Pro Leu Lys Lys Lys Met Glu Lys 
     1170                1175                1180



<210> 9513
<211> 4986
<212> DNA
<213> Homo sapiens
<308> NM_012211
<400> 9513

aggaggctg  cgctctggc  tgccgcccc  cgccgccgc  gcacaccgg  cccagccgc  60
gtgccgcgg  ccatggacc  gcccagggg  ctggtggtg  cctgggcgc  cagcctgtg  120
ccagggttc  cggacacct  caacatgga  accaggaag  cccgggtca  ccctggctc  180
aggaccgcc  tctttggct  cacagtgca  cagcacgac  tcagtggca  taagtggct  240
gtcgtgggc  ccccactgg  aaccaatgg  taccagaag  cgggagacg  gtacaagtg  300
ccagtgatc  acgggaact  caccaaact  aacctggga  gggtcaccc  gtccaacgt  360
tccgagcgg  aagacaaca  gcgcctcgg  cttagtctc  ccaccaacc  caaggacaa  420
agcttcctg  cctgcagcc  cctctggtc  catgagtgt  ggagctcct  ctacaccac  480
gggatgtgt  caagagtca  ctccaactt  aggttctcc  agaccgtgg  cccagctct  540
caaaggtgc  agacctaca  ggacatcgt  attgtcctg  atggctcca  cagcatcta  600
ccctgggtg  aggttcagc  cttcctcat  aacatcctg  aaaagtttt  cattggccc  660
gggcagatc  aggttggag  tgtgcagta  ggcgaagat  tggtgcatg  gtttcacct  720
aatgactac  ggtctgtaa  agatgtggt  gaagctgcc  gccacattg  gcagagagg  780
ggaacagag  cccggacgg  atttggcat  gaatttgca  gctcagagg  tttccagaa  840
ggtggaagg  aaggagcca  gaaggtgat  attgtcatc  cagatgggg  gtcccacga  900
agcccagac  tggagaagg  gatccagca  agcgaaaga  acaacgtaa  aagatatgc  960
gtggccgtc  tgggctact  caaccgcag  gggatcaat  cagaaactt  tctaaatga  1020
atcaaatac  tcgccagtg  ccctgatga  aagcacttc  tcaatgtca  tgatgaggc  1080
gccttgaag  acattgtcg  tgccctggg  gacagaatc  tcagcctgg  aggcaccaa  1140
aagaacgag  cctcctttg  gctggagat  tcacagacg  gcttttcct  gcacgtggt  1200
gaggatggg  ttctgctgg  agccgtcgg  gcctatgac  ggaatggag  tgtgctaaa  1260
gagacgagt  ccgggaagg  cattcctct  cgcgagtcc  acctgaaag  gttccccga  1320
gagctcaag  accatggtg  atacctggg  tacacagtc  catcggtcg  gtcctccag  1380
caggggcga  tgtacgtgg  cggagcccc  cggttcaac  acacgggca  ggtcatcct  1440
ttcaccatg  acaacaacc  gagcctcac  atccaccag  ctatgcggg  ccagcagat  1500
ggctcttac  ttgggagtg  aatcacctc  gtggacatc  acggcgacg  cgtgactga  1560
gtcctgctg  tgggcgcac  catgtactt  aacgagggc  gtgagcgag  caaggtgta  1620
gtctatgag  tgagacaga  ccggtttgt  tataacgga  cgctaaagg  ttcacacag  1680
taccagaat  cccgatttg  gtcctccat  gcctcagtt  gagacctca  ccaggattc  1740
tacaatgac  tggtggtgg  agcccccct  gaggacaac  acgcaggag  catctacat  1800
ttccacggc  tccgaggca  catcctgaa  acacctaag  agagaatca  agcctcaga  1860
ctggctacc  gcctccagt  ttttggctg  agcatccac  ggcaattgg  cctcaatga  1920
gatgggctc  tcgacctgg  agtgggagc  cttggcaac  ctgtgattc  gtggtcccg  1980
ccagtggtt  agatcaatg  cagcctcca  tttgagcca  ccaagatca  catcttcca  2040
agagactgc  agcgcagtg  cagggatgc  acctgcctg  ccgccttcc  ctgcttcac  2100
cccatcttc  tggcacccc  tttccaaac  acaactgtt  gcatcagat  caacgccac  2160
atggatgag  ggcggtata  accgagggc  cacctggac  agggcgggg  ccgattcac  2220
aacagagcc  tactgctct  ctccggcca  gagctctgt  agcggatca  cttccatgt  2280
ctggacact  ctgactacg  gaagccagt  accttctca  tcgagtatt  cctggagga  2340
cctgaccat  gccccatgc  ggacgacgg  tggcccacc  ctctcagag  ctcggtgcc  2400
ttctggaac  gctgcaatg  ggatgagca  tgtgtccct  accttgtgt  ggatgcccg  2460
agtgacctg  ccacggcca  ggagtactg  cagagggtg  tgaggaagc  tgcgcagga  2520
tgctccgca  acacgctgt  cttcgacac  acagtcttc  tcatagaga  cacacgcca  2580
cgagtggcg  tggaggcca  actggagaa  aggggcgag  acgcctaca  cacggtcct  2640
aatatctcg  agtcagcaa  cctgcagtt  gccagcttg  tccagaagg  ggactcaga  2700
ggtagcatt  agtgtgtga  cgaggagag  aggctccag  agcaagtct  caacgtcag  2760
tatcccttc  tccgggcca  ggccaaggt  gctttccgt  ttgattttg  gttcagcaa  2820
tccatcttc  tacaccacc  ggagatcga  ctcgctgca  gcagtgaca  taatgagcg  2880
gacagcacc  aggaagaca  cgtggcccc  ttacgcttc  acctcaaat  cgaggctga  2940
gtcctcttc  ccaggagca  cagcctgag  cactacgag  tcaagctca  cagctcgct  3000
gagagatac  atggtatcg  gcctccctt  agctgcatc  tcaggatcc  gaacttggg  3060
ttgttcccc  tccacggga  tatgatgaa  atcaccatt  ccatcgcca  caggagcgg  3120
aaccgccta  tgaagctga  ggacttcct  acggacgag  tagcgaaca  gtcctgtaa  3180
atctggggc  atagcactg  gtaccggcc  accccagtg  aggaagact  gcgtcgtgc  3240
ccacagctg  atcacagca  ctctgatgt  gtctccatc  actgcaata  acggctggt  3300
cccaaccag  aaatcaatt  ccatctact  gggaacctg  ggttgaggt  cctaaaagc  3360
ctcaagtac  aatccatga  aatcatggt  aacgcagcc  tgcagaggc  gttccacag  3420
cccttcatc  tccgtgagg  ggatcccag  cgccagatc  tgtttgaga  ctccaagca  3480
gaggactgg  aggtcccca  ctggatcat  gtaggcagc  ccctggggg  cctcctact  3540
ctggccctg  tggtcctgg  actgtggaa  ctcggcttc  ttagaagtg  caggcgcag  3600
agggagcct  gtctggacc  cacccccaa  gtgctggag  gaggctcca  aggagactt  3660
gagttgatg  gggccagga  accagtcca  gtagtgttg  gacccaggc  tgtggcccc  3720
ccgagctgg  gcggagagg  agccagctg  ctttgcact  gacctcatc  cccgagcaa  3780
ggcgcctgc  ccctccaga  tggaactca  gctggtttt  agtggaact  ccctactgg  3840
agactggga  acctttaac  cagacccct  gggatttaa  gggacaccc  tacacacac  3900
caggcccac  ccaaggcct  cctcaggct  tgtggaggg  atttgctgc  ccagctact  3960
aggtgctag  aattcgtaa  catccccat  ctccagaga  acccaggga  gaagactgt  4020
aatacgaac  caatctgca  actccaggc  tctagttcc  gaaggatcc  agacaaaac  4080
gatctgaat  ctgcccttt  ctctcaccc  tcccacccc  ccattggct  ccaagtcac  4140
cccactccc  tccccatag  taggcccct  gggctcccg  agaatgaac  caagagcaa  4200
ggcttgatg  tgacagctg  aagccaggg  tgaagaaag  ctctgagat  tggagactg  4260
tggccaggc  agtgggacc  ggatactgg  cgctgtcct  agatgagag  tagccgggc  4320
ctgcaccca  gtgcattca  attgaccgc  actcacaca  tcccccacc  gctgcagcc  4380
cttgctctc  gctgccaac  ctcccgggt  acttttgtt  ccaggtacc  catgggaag  4440
atgtggatg  cacaatccc  ggggctgtg  attcccacg  cttcttgct  cagcctgcc  4500
ctagacatg  acgcaccgg  ctggctgca  ctgggcagc  ggggtaggg  tagggagcc  4560
cccctccct  tatcacccc  tccctacac  cacacacac  cacacacac  cacactgcc  4620
cccatcctt  cctcatgcc  gccagtgca  agggaaggg  ttggccagc  ctgttgagg  4680
gtcccctct  gaatgcact  aataaagca  gtgcaagga  tcccggagc  tgtgcagcc  4740
tggtggcaa  tatctcatc  gccggcccc  aggacaagt  gtatgacca  tgataatgc  4800
ccaaggaca  ggggcgtgc  tggcgccca  tggagtaat  tatgcctta  tcttgtttt  4860
aggtagaaa  gcaaggggg  cacatgaaa  gcatcagtc  ccctgtgca  agtacgacc  4920
ttactgtcg  atttttgaa  aattaaaaa  acagtgttt  aaaacaaaa  aaaaaaaaa  4980
aaaaaa  4986



<210> 9514
<211> 1189
<212> PRT
<213> Homo sapiens
<308> Q9UKX5
<400> 9514

Met Asp Leu Pro Arg Gly Leu Val Val Ala Trp Ala Leu Ser Leu Trp 
  1               5                  10                  15
Pro Gly Phe Thr Asp Thr Phe Asn Met Asp Thr Arg Lys Pro Arg Val 
             20                  25                  30
Ile Pro Gly Ser Arg Thr Ala Phe Phe Gly Tyr Thr Val Gln Gln His 
         35                  40                  45
Asp Ile Ser Gly Asn Lys Trp Leu Val Val Gly Ala Pro Leu Glu Thr 
     50                  55                  60
Asn Gly Tyr Gln Lys Thr Gly Asp Val Tyr Lys Cys Pro Val Ile His 
 65                  70                  75                  80
Gly Asn Cys Thr Lys Leu Asn Leu Gly Arg Val Thr Leu Ser Asn Val 
                 85                  90                  95
Ser Glu Arg Lys Asp Asn Met Arg Leu Gly Leu Ser Leu Ala Thr Asn 
             100                105                110
Pro Lys Asp Asn Ser Phe Leu Ala Cys Ser Pro Leu Trp Ser His Glu 
         115                120                125
Cys Gly Ser Ser Tyr Tyr Thr Thr Gly Met Cys Ser Arg Val Asn Ser 
     130                135                140
Asn Phe Arg Phe Ser Lys Thr Val Ala Pro Ala Leu Gln Arg Cys Gln 
 145                150                155                160
Thr Tyr Met Asp Ile Val Ile Val Leu Asp Gly Ser Asn Ser Ile Tyr 
                 165                170                175
Pro Trp Val Glu Val Gln His Phe Leu Ile Asn Ile Leu Lys Lys Phe 
             180                185                190
Tyr Ile Gly Pro Gly Gln Ile Gln Val Gly Val Val Gln Tyr Gly Glu 
         195                200                205
Asp Val Val His Glu Phe His Leu Asn Asp Tyr Arg Ser Val Lys Asp 
     210                215                220
Val Val Glu Ala Ala Ser His Ile Glu Gln Arg Gly Gly Thr Glu Thr 
 225                230                235                240
Arg Thr Ala Phe Gly Ile Glu Phe Ala Arg Ser Glu Ala Phe Gln Lys 
                 245                250                255
Gly Gly Arg Lys Gly Ala Lys Lys Val Met Ile Val Ile Thr Asp Gly 
             260                265                270
Glu Ser His Asp Ser Pro Asp Leu Glu Lys Val Ile Gln Gln Ser Glu 
         275                280                285
Arg Asp Asn Val Thr Arg Tyr Ala Val Ala Val Leu Gly Tyr Tyr Asn 
     290                295                300
Arg Arg Gly Ile Asn Pro Glu Thr Phe Leu Asn Glu Ile Lys Tyr Ile 
 305                310                315                320
Ala Ser Asp Pro Asp Asp Lys His Phe Phe Asn Val Thr Asp Glu Ala 
                 325                330                335
Ala Leu Lys Asp Ile Val Asp Ala Leu Gly Asp Arg Ile Phe Ser Leu 
             340                345                350
Glu Gly Thr Asn Lys Asn Glu Thr Ser Phe Gly Leu Glu Met Ser Gln 
         355                360                365
Thr Gly Phe Ser Ser His Val Val Glu Asp Gly Val Leu Leu Gly Ala 
     370                375                380
Val Gly Ala Tyr Asp Trp Asn Gly Ala Val Leu Lys Glu Thr Ser Ala 
 385                390                395                400
Gly Lys Val Ile Pro Leu Arg Glu Ser Tyr Leu Lys Glu Phe Pro Glu 
                 405                410                415
Glu Leu Lys Asn His Gly Ala Tyr Leu Gly Tyr Thr Val Thr Ser Val 
             420                425                430
Val Ser Ser Arg Gln Gly Arg Val Tyr Val Ala Gly Ala Pro Arg Phe 
         435                440                445
Asn His Thr Gly Lys Val Ile Leu Phe Thr Met His Asn Asn Arg Ser 
     450                455                460
Leu Thr Ile His Gln Ala Met Arg Gly Gln Gln Ile Gly Ser Tyr Phe 
 465                470                475                480
Gly Ser Glu Ile Thr Ser Val Asp Ile Asp Gly Asp Gly Val Thr Asp 
                 485                490                495
Val Leu Leu Val Gly Ala Pro Met Tyr Phe Asn Glu Gly Arg Glu Arg 
             500                505                510
Gly Lys Val Tyr Val Tyr Glu Leu Arg Gln Asn Arg Phe Val Tyr Asn 
         515                520                525
Gly Thr Leu Lys Asp Ser His Ser Tyr Gln Asn Ala Arg Phe Gly Ser 
     530                535                540
Ser Ile Ala Ser Val Arg Asp Leu Asn Gln Asp Ser Tyr Asn Asp Val 
 545                550                555                560
Val Val Gly Ala Pro Leu Glu Asp Asn His Ala Gly Ala Ile Tyr Ile 
                 565                570                575
Phe His Gly Phe Arg Gly Ser Ile Leu Lys Thr Pro Lys Gln Arg Ile 
             580                585                590
Thr Ala Ser Glu Leu Ala Thr Gly Leu Gln Tyr Phe Gly Cys Ser Ile 
         595                600                605
His Gly Gln Leu Asp Leu Asn Glu Asp Gly Leu Ile Asp Leu Ala Val 
     610                615                620
Gly Ala Leu Gly Asn Ala Val Ile Leu Trp Ser Arg Pro Val Val Gln 
 625                630                635                640
Ile Asn Ala Ser Leu His Phe Glu Pro Ser Lys Ile Asn Ile Phe His 
                 645                650                655
Arg Asp Cys Lys Arg Ser Gly Arg Asp Ala Thr Cys Leu Ala Ala Phe 
             660                665                670
Leu Cys Phe Thr Pro Ile Phe Leu Ala Pro His Phe Gln Thr Thr Thr 
         675                680                685
Val Gly Ile Arg Tyr Asn Ala Thr Met Asp Glu Arg Arg Tyr Thr Pro 
     690                695                700
Arg Ala His Leu Asp Glu Gly Gly Asp Arg Phe Thr Asn Arg Ala Val 
 705                710                715                720
Leu Leu Ser Ser Gly Gln Glu Leu Cys Glu Arg Ile Asn Phe His Val 
                 725                730                735
Leu Asp Thr Ala Asp Tyr Val Lys Pro Val Thr Phe Ser Val Glu Tyr 
             740                745                750
Ser Leu Glu Asp Pro Asp His Gly Pro Met Leu Asp Asp Gly Trp Pro 
         755                760                765
Thr Thr Leu Arg Val Ser Val Pro Phe Trp Asn Gly Cys Asn Glu Asp 
     770                775                780
Glu His Cys Val Pro Asp Leu Val Leu Asp Ala Arg Ser Asp Leu Pro 
 785                790                795                800
Thr Ala Met Glu Tyr Cys Gln Arg Val Leu Arg Lys Pro Ala Gln Asp 
                 805                810                815
Cys Ser Ala Tyr Thr Leu Ser Phe Asp Thr Thr Val Phe Ile Ile Glu 
             820                825                830
Ser Thr Arg Gln Arg Val Ala Val Glu Ala Thr Leu Glu Asn Arg Gly 
         835                840                845
Glu Asn Ala Tyr Ser Thr Val Leu Asn Ile Ser Gln Ser Ala Asn Leu 
     850                855                860
Gln Phe Ala Ser Leu Ile Gln Lys Glu Asp Ser Asp Gly Ser Ile Glu 
 865                870                875                880
Cys Val Asn Glu Glu Arg Arg Leu Gln Lys Gln Val Cys Asn Val Ser 
                 885                890                895
Tyr Pro Phe Phe Arg Ala Lys Ala Lys Val Ala Phe Arg Leu Asp Phe 
             900                905                910
Glu Phe Ser Lys Ser Ile Phe Leu His His Leu Glu Ile Glu Leu Ala 
         915                920                925
Ala Gly Ser Asp Ser Asn Glu Arg Asp Ser Thr Lys Glu Asp Asn Val 
     930                935                940
Ala Pro Leu Arg Phe His Leu Lys Tyr Glu Ala Asp Val Leu Phe Thr 
 945                950                955                960
Arg Ser Ser Ser Leu Ser His Tyr Glu Val Lys Leu Asn Ser Ser Leu 
                 965                970                975
Glu Arg Tyr Asp Gly Ile Gly Pro Pro Phe Ser Cys Ile Phe Arg Ile 
             980                985                990
Gln Asn Leu Gly Leu Phe Pro Ile His Gly Ile Met Met Lys Ile Thr 
         995                1000                1005
Ile Pro Ile Ala Thr Arg Ser Gly Asn Arg Leu Leu Lys Leu Arg Asp 
     1010                1015                1020
Phe Leu Thr Asp Glu Val Ala Asn Thr Ser Cys Asn Ile Trp Gly Asn 
 1025                1030                1035                1040
Ser Thr Glu Tyr Arg Pro Thr Pro Val Glu Glu Asp Leu Arg Arg Ala 
                 1045                1050                1055
Pro Gln Leu Asn His Ser Asn Ser Asp Val Val Ser Ile Asn Cys Asn 
             1060                1065                1070
Ile Arg Leu Val Pro Asn Gln Glu Ile Asn Phe His Leu Leu Gly Asn 
         1075                1080                1085
Leu Trp Leu Arg Ser Leu Lys Ala Leu Lys Tyr Lys Ser Met Lys Ile 
     1090                1095                1100
Met Val Asn Ala Ala Leu Gln Arg Gln Phe His Ser Pro Phe Ile Phe 
 1105                1110                1115                1120
Arg Glu Glu Asp Pro Ser Arg Gln Ile Val Phe Glu Ile Ser Lys Gln 
                 1125                1130                1135
Glu Asp Trp Gln Val Pro Ile Trp Ile Ile Val Gly Ser Thr Leu Gly 
             1140                1145                1150
Gly Leu Leu Leu Leu Ala Leu Leu Val Leu Ala Leu Trp Lys Leu Gly 
         1155                1160                1165
Phe Phe Arg Ser Ala Arg Arg Arg Arg Glu Pro Gly Leu Asp Pro Thr 
     1170                1175                1180
Pro Lys Val Leu Glu 
 1185



<210> 9515
<211> 3114
<212> DNA
<213> Rattus norvegicus
<308> X52711
<400> 9515

caggagctt  cctgacccc  gtggcaagg  ttccagatt  ttctgaatc  aacccttta  60
gtccaaccg  atccacctg  aaaacacgc  agagtgagt  cctagaacg  caaaatgaa  120
gagcggacc  ctgcatgcc  tcacgggac  ccacagaaa  atcctgata  ctctgaaga  180
agccaggca  tggagtctg  ggataacct  tgcagtcag  atgaggaga  ggtgcggcc  240
tgcattgac  tcatcgact  cctgcgagc  ctgggtgtg  agcaagacc  ggccctgcc  300
gccatcgct  tcattgggg  ccagagttc  gggaagagc  ctgtgctgg  agcactgtc  360
ggagtggcc  tccccagag  cagtggtat  gttaccagg  gtcctctgg  gctgaaatt  420
aagcaactg  agcagggag  aaaatggag  ggcaaggtc  tttataagg  caccgagat  480
gagatctca  acccttcac  ggtagaaag  gaaatcaat  aagcccaga  cttgattgc  540
ggggaaggg  tgaagatta  ctctgatct  attagcttg  aggttagct  tccacatgt  600
ccagacctg  ctctgattg  ccttcctgg  atcacaaga  tggctgtgg  tgaccagcc  660
gcagacatc  aacacaaga  caagagact  atcactgaa  acatccaga  acaggagac  720
atcaacctg  tggtggtcc  cagcaatgt  gacattgcc  ccacagagg  cctgaaaat  780
gctcaggag  tggaccctc  aggggatag  accataggg  tcttgacca  gcccgatct  840
gtggacaga  ggactgaag  caaggtcgt  gatgtggtg  ggaacctcg  gtgccacct  900
aagaagggc  acatgatag  caagtgcag  ggtcagcag  acatccagg  gcagctgag  960
ctggctgag  ctcttcaga  ggagcaagt  ttcttcaag  aacaccctc  attcagagt  1020
cttctcgag  atgggaagg  cacagtgcc  tgcttggca  agagactga  catggagct  1080
acctcccac  tctgtaaat  gctgccaat  ttggaaaat  aaataaatg  gaatcatca  1140
attgcgagt  aggagctgc  gaagtacgg  gcagacata  cagaagatg  cagtaagag  1200
ctgtccttt  tgatgaata  aatcaatgt  ttcaataag  atatcctaa  tttggtaca  1260
gcacaagaa  acatatcat  ggaagaaag  cggctgttc  ccaaactgc  aaatgagtt  1320
cttgcttgg  atgattata  tgaggaaca  ttcaaaaaa  ccctaggtt  ttctgagaa  1380
cacagccag  tggaaaaat  tgaaagtca  tatcgtggc  gggaactgc  agggtttgt  1440
gactataag  catttgaga  cattatcaa  aaggaagtc  aggccctgg  agaacccgc  1500
ctgaacatg  tgcacaggg  cactaccat  gtcaaaaat  ccttcacaa  ggtttcatc  1560
aacaatttt  gtgattttt  aaacctcca  agtactgcc  agtccaaaa  tgaagacat  1620
agatttaac  aagaaaaag  agccgaaaa  ctgatccga  ttcacttcc  gatggaaca  1680
attgtctac  gccaggacc  ggcttacaa  aaagccttg  aggagatca  agagaagga  1740
gctgagaaa  agaagtcaa  ctttggtgc  tttcaacat  actctcctc  aaaggagtt  1800
actaccact  agatgaccc  gcacctgaa  gcctactac  aggagtgcg  aaggaacat  1860
gggagacag  tccctctga  catccagta  tccatcctg  aaacatttg  gcaggaaat  1920
gagaaagca  tgcttcagc  tctacagga  accagtaag  gcaactggt  cctgactga  1980
cagagtgac  gcagagaga  gaagaagtt  ctgaagagg  ggcttttaa  gctggatga  2040
gctcagcgg  agcttgcca  attctccaa  taatcaggc  tgctatgtg  cttccctgg  2100
cacagctag  gtcccctgc  caatgaccc  ttagctgtt  accttatgt  agtatgttg  2160
ctttagact  tggaagcat  ccctctgca  actctgagg  gacgaagag  ggagccatg  2220
agagtcatt  tacttcagc  gtaagacac  accctctca  agcacagga  gctggcacc  2280
ctcagggtc  ttcctgctc  taactgcca  ttctttgtc  ggaggatgt  ctggctgag  2340
acttcagaa  ggatgtctc  tggctttgt  ctgctctgc  tggagtagt  ctagaggtg  2400
gacagagtc  tagcaggac  gctctttgt  ggcataaat  ttttgcaac  taattttag  2460
aagggttca  cctcacttt  agcccacca  ccatcagag  tagtgggac  gaaaagtta  2520
taggatatg  gggaagtgc  cagcaatag  tctttgggg  tgagctcaa  tttctttgg  2580
agcataaca  acaccaaat  agactcaga  gttgcagat  agtcctcta  gcaggcaga  2640
accaggcac  aaccagcag  tgtagatca  tcttaaaga  agctcgcca  ccagcctga  2700
gtaaggctg  ggaagcagc  aacttcctc  gcaacctca  aagtagttc  taggcaagt  2760
tcttctaat  gtagtgtta  cacaagttg  gcccaacaa  gctatgcaa  gcaaaccat  2820
acatgcacg  tgttagtga  gaataagta  gcagagcaa  ccaacgctc  gttgctcgt  2880
tcccagtgt  ttgtggggc  gtatttatc  ccttcatca  gggtccttt  acatgtttg  2940
aatattaaa  catcctttc  cctgtgtcc  cttcaggac  acagtcttt  acaagtttg  3000
ttcagcaag  caccctttc  cctgtgtgc  ccagcaaaa  atcatttga  ataactttc  3060
aaagaaact  gaagtttcc  cttcaagtt  ttccaataa  attcttgct  aatg  3114



<210> 9516
<211> 652
<212> PRT
<213> Rattus norvegicus
<308> P18588
<400> 9516

Met Lys Glu Arg Thr Ser Ala Cys Arg His Gly Thr Pro Gln Lys His 
  1               5                  10                  15
Pro Asp Thr Ser Glu Glu Ser Gln Ala Met Glu Ser Val Asp Asn Leu 
             20                  25                  30
Cys Ser Gln Tyr Glu Glu Lys Val Arg Pro Cys Ile Asp Leu Ile Asp 
         35                  40                  45
Ser Leu Arg Ala Leu Gly Val Glu Gln Asp Leu Ala Leu Pro Ala Ile 
     50                  55                  60
Ala Val Ile Gly Asp Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ala 
 65                  70                  75                  80
Leu Ser Gly Val Ala Leu Pro Arg Gly Ser Gly Ile Val Thr Arg Cys 
                 85                  90                  95
Pro Leu Val Leu Lys Leu Lys Gln Leu Lys Gln Gly Glu Lys Trp Ser 
             100                105                110
Gly Lys Val Ile Tyr Lys Asp Thr Glu Ile Glu Ile Ser His Pro Ser 
         115                120                125
Leu Val Glu Arg Glu Ile Asn Lys Ala Gln Asn Leu Ile Ala Gly Glu 
     130                135                140
Gly Leu Lys Ile Ser Ser Asp Leu Ile Ser Leu Glu Val Ser Ser Pro 
 145                150                155                160
His Val Pro Asp Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Arg Val 
                 165                170                175
Ala Val Gly Asp Gln Pro Ala Asp Ile Glu His Lys Ile Lys Arg Leu 
             180                185                190
Ile Thr Glu Tyr Ile Gln Lys Gln Glu Thr Ile Asn Leu Val Val Val 
         195                200                205
Pro Ser Asn Val Asp Ile Ala Thr Thr Glu Ala Leu Lys Met Ala Gln 
     210                215                220
Glu Val Asp Pro Gln Gly Asp Arg Thr Ile Gly Ile Leu Thr Lys Pro 
 225                230                235                240
Asp Leu Val Asp Arg Gly Thr Glu Asp Lys Val Val Asp Val Val Arg 
                 245                250                255
Asn Leu Val Cys His Leu Lys Lys Gly Tyr Met Ile Val Lys Cys Arg 
             260                265                270
Gly Gln Gln Asp Ile Gln Glu Gln Leu Ser Leu Ala Glu Ala Leu Gln 
         275                280                285
Lys Glu Gln Val Phe Phe Lys Glu His Pro Gln Phe Arg Val Leu Leu 
     290                295                300
Glu Asp Gly Lys Ala Thr Val Pro Cys Leu Ala Lys Arg Leu Thr Met 
 305                310                315                320
Glu Leu Thr Ser His Ile Cys Lys Ser Leu Pro Ile Leu Glu Asn Gln 
                 325                330                335
Ile Asn Val Asn His Gln Ile Ala Ser Glu Glu Leu Gln Lys Tyr Gly 
             340                345                350
Ala Asp Ile Pro Glu Asp Asp Ser Lys Arg Leu Ser Phe Leu Met Asn 
         355                360                365
Lys Ile Asn Val Phe Asn Lys Asp Ile Leu Ser Leu Val Gln Ala Gln 
     370                375                380
Glu Asn Ile Ser Trp Glu Glu Ser Arg Leu Phe Thr Lys Leu Arg Asn 
 385                390                395                400
Glu Phe Leu Ala Trp Asn Asp Tyr Ile Glu Glu His Phe Lys Lys Thr 
                 405                410                415
Leu Gly Ser Ser Glu Lys His Ser Gln Met Glu Lys Phe Glu Ser His 
             420                425                430
Tyr Arg Gly Arg Glu Leu Pro Gly Phe Val Asp Tyr Lys Ala Phe Glu 
         435                440                445
Asn Ile Ile Lys Lys Glu Val Lys Ala Leu Glu Glu Pro Ala Leu Asn 
     450                455                460
Met Leu His Arg Val Thr Thr Met Val Lys Asn Ala Phe Thr Lys Val 
 465                470                475                480
Ser Ser Asn Asn Phe Gly Asp Phe Leu Asn Leu His Ser Thr Ala Lys 
                 485                490                495
Ser Lys Ile Glu Asp Ile Arg Phe Asn Gln Glu Lys Glu Ala Glu Lys 
             500                505                510
Leu Ile Arg Leu His Phe Gln Met Glu His Ile Val Tyr Cys Gln Asp 
         515                520                525
Gln Ala Tyr Lys Lys Ala Leu Gln Glu Ile Arg Glu Lys Glu Ala Glu 
     530                535                540
Lys Glu Lys Ser Thr Phe Gly Ala Phe Gln His Asn Ser Pro Arg Lys 
 545                550                555                560
Glu Leu Thr Thr Thr Glu Met Thr Gln His Leu Asn Ala Tyr Tyr Gln 
                 565                570                575
Glu Cys Gly Arg Asn Ile Gly Arg Gln Ile Pro Leu Ile Ile Gln Tyr 
             580                585                590
Ser Ile Leu Gln Thr Phe Gly Gln Glu Met Glu Lys Ala Met Leu Gln 
         595                600                605
Leu Leu Gln Asp Thr Ser Lys Cys Asn Trp Phe Leu Thr Glu Gln Ser 
     610                615                620
Asp Ser Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg Leu Leu Arg Leu 
 625                630                635                640
Asp Glu Ala Gln Arg Lys Leu Ala Lys Phe Ser Asn 
                 645                650



<210> 9517
<211> 2787
<212> DNA
<213> Homo sapiens
<308> NM_002462
<400> 9517

agagcggag  ccgcactcc  gcactgcgc  gggaccgcc  tggaccgca  ttgccggcc  60
ggaatccca  tgtcacggt  gacacgcct  cctcgcgcc  ttgccgccc  cctgctcac  120
cagctcagg  gctttggaa  tctgtggcc  cactgcgag  agatcggtt  tgggtcgga  180
gctacagga  gactcccac  ccctgaaat  tggagtgaa  aacgccgcc  tccagccac  240
attccaagg  ggtgcagga  aacagctct  tgataccat  taacttgtt  acattactt  300
tatttgaag  aacgtatat  agagcttac  ttgcaaaga  ggaagatgg  tgtttccga  360
gtggacatc  caaaagctg  tccagctgc  gcatcccac  ctctattac  gaatggaga  420
gctactgtg  cccagaaaa  tccaggctc  gtggctgag  acaacctgt  cagccagta  480
gaggagaag  tgcgcccct  catcgacct  attgactcc  tgcgggctc  aggtgtgga  540
caggacctg  ccctgccag  catcgccgt  atcggggac  agagctcgg  caagagctc  600
gtgttggag  cactgtcag  agttgccct  cccagaggc  gcgggatcg  gaccagatg  660
ccgctggtg  tgaaactga  gaaacttgt  aacgaagat  agtggagag  caaggtcag  720
taccaggac  acgagattg  gatttcgga  gcttcagag  tagaaaagg  aattaataa  780
gcccagaat  ccatcgccg  ggaaggaat  ggaatcagt  atgagctaa  caccctgga  840
atcagctcc  gagatgtcc  ggatctgac  ctaatagac  ttcctggca  aaccagagt  900
gctgtgggc  atcagcctg  tgacattgg  tataagatc  agacactca  caagaagta  960
atccagagg  aggagacaa  cagcctggt  gtggtcccc  gtaatgtgg  catcgccac  1020
acagaggct  tcagcatgg  ccaggaggt  gaccccgag  gagacagga  catcggaat  1080
ttgacgaag  ctgatctgg  ggacaaagg  actgaagac  aggttgtgg  cgtggtgcg  1140
aacctcgtg  tccacctga  gaagggtta  atgattgtc  agtgccggg  ccagcagga  1200
atccaggac  agctgagcc  gtccgaagc  ctgcagaga  agaagatct  ctttgagaa  1260
cacccatat  tcagggatc  gctggagga  ggaaaggcc  cggttccct  cctggcaga  1320
aaacttacc  gcgagctca  cacacatat  tgtaaatct  tgcccctgt  agaaaatca  1380
atcaaggag  ctcaccaga  aataacaga  gagctacaa  agtatggtg  cgacatacc  1440
gaagacgaa  atgaaaaaa  gttcttcct  atagataaa  ttaatgcct  taatcagga  1500
atcactgct  tcatgcaag  agaggaaac  gtaggggag  aagacattc  gctgtttac  1560
agactccga  acgagttcc  caaatggag  acaataatt  aaaacaatt  tcaagaagg  1620
cataaaatt  tgagtagaa  aatccagaa  tttgaaaat  agtatcgtg  tagagagct  1680
ccaggcttt  tgaattaca  gacatttga  acaatcgtg  aacagcaaa  caaggcact  1740
gaagagccg  ctgtggata  gctacacac  gtgacggat  tggtccggc  tgctttcac  1800
gatgtttcg  taaaaaatt  tgaagagtt  tttaacctc  acagaaccg  caagtccaa  1860
attgaagac  ttagagcag  acaagagag  gaaggtgag  agctgatcc  cctccactt  1920
cagatggaa  agattgtct  ctgccagga  caggtatac  ggggtgcat  gcagaaggt  1980
agagagaag  agctggaag  agaaaagaa  aagaaatcc  gggattttg  ggctttcca  2040
tccagctcg  caacagact  ttccatgga  gagatcttt  agcacctga  ggcctatca  2100
caggaggcc  gcaagcgca  ctccagcca  atccctttg  tcatccagt  cttcatgct  2160
cagacgtac  gccagcagc  tcagaaggc  atgctgcag  tcctgcagg  caaggacac  2220
tacagctgg  tcctgaagg  gcggagcga  accagcgac  agcggaagt  cctgaagga  2280
cggcttgca  ggctgacgc  ggctcggcg  cggcttgcc  agttccccg  ttaaccaca  2340
tctgtccag  cccgtagac  tgcacgcac  ctgtctgcc  ccgttcccg  gtagccact  2400
gactgacga  ttgagtgct  agtagtcag  ctggatagt  cgtctctgc  tatccgtta  2460
ccgtggtga  ttagcagga  gctgtgaga  cagtttggt  tctagcatg  agacagagc  2520
ccaccctca  atgcacatg  gctggcggg  ttgaaggat  ctgtcttcg  actgggaaa  2580
ggattttca  ccctcagaa  cgctccacc  tgcagctct  cccttctct  tattcctag  2640
aactgacac  tgctgaaca  cacagctta  ttcctcatt  ttataatgt  ccttcacaa  2700
cccagtgtt  taggagcat  agtgccgtg  gtgtgcgtc  tgtcggagc  ctgtctcct  2760
tctctgtaa  aaactcatt  ctagcag  2787



<210> 9518
<211> 661
<212> PRT
<213> Homo sapiens
<308> P20591
<400> 9518

Val Val Ser Glu Val Asp Ile Ala Lys Ala Asp Pro Ala Ala Ala Ser 
  1               5                  10                  15
His Pro Leu Leu Leu Asn Gly Asp Ala Thr Val Ala Gln Lys Asn Pro 
             20                  25                  30
Gly Ser Val Ala Glu Asn Asn Leu Cys Ser Gln Tyr Glu Glu Lys Val 
         35                  40                  45
Arg Pro Cys Ile Asp Leu Ile Asp Ser Leu Arg Ala Leu Gly Val Glu 
     50                  55                  60
Gln Asp Leu Ala Leu Pro Ala Ile Ala Val Ile Gly Asp Gln Ser Ser 
 65                  70                  75                  80
Gly Lys Ser Ser Val Leu Glu Ala Leu Ser Gly Val Ala Leu Pro Arg 
                 85                  90                  95
Gly Ser Gly Ile Val Thr Arg Cys Pro Leu Val Leu Lys Leu Lys Lys 
             100                105                110
Leu Val Asn Glu Asp Lys Trp Arg Gly Lys Val Ser Tyr Gln Asp Tyr 
         115                120                125
Glu Ile Glu Ile Ser Asp Ala Ser Glu Val Glu Lys Glu Ile Asn Lys 
     130                135                140
Ala Gln Asn Ala Ile Ala Gly Glu Gly Met Gly Ile Ser His Glu Leu 
 145                150                155                160
Ile Thr Leu Glu Ile Ser Ser Arg Asp Val Pro Asp Leu Thr Leu Ile 
                 165                170                175
Asp Leu Pro Gly Ile Thr Arg Val Ala Val Gly Asn Gln Pro Ala Asp 
             180                185                190
Ile Gly Tyr Lys Ile Lys Thr Leu Ile Lys Lys Tyr Ile Gln Arg Gln 
         195                200                205
Glu Thr Ile Ser Leu Val Val Val Pro Ser Asn Val Asp Ile Ala Thr 
     210                215                220
Thr Glu Ala Leu Ser Met Ala Gln Glu Val Asp Pro Glu Gly Asp Arg 
 225                230                235                240
Thr Ile Gly Ile Leu Thr Lys Pro Asp Leu Val Asp Lys Gly Thr Glu 
                 245                250                255
Asp Lys Val Val Asp Val Val Arg Asn Leu Val Phe His Leu Lys Lys 
             260                265                270
Gly Tyr Met Ile Val Lys Cys Arg Gly Gln Gln Glu Ile Gln Asp Gln 
         275                280                285
Leu Ser Leu Ser Glu Ala Leu Gln Arg Glu Lys Ile Phe Phe Glu Asn 
     290                295                300
His Pro Tyr Phe Arg Asp Leu Leu Glu Glu Gly Lys Ala Thr Val Pro 
 305                310                315                320
Cys Leu Ala Glu Lys Leu Thr Ser Glu Leu Ile Thr His Ile Cys Lys 
                 325                330                335
Ser Leu Pro Leu Leu Glu Asn Gln Ile Lys Glu Thr His Gln Arg Ile 
             340                345                350
Thr Glu Glu Leu Gln Lys Tyr Gly Val Asp Ile Pro Glu Asp Glu Asn 
         355                360                365
Glu Lys Met Phe Phe Leu Ile Asp Lys Ile Asn Ala Phe Asn Gln Asp 
     370                375                380
Ile Thr Ala Leu Met Gln Gly Glu Glu Thr Val Gly Glu Glu Asp Ile 
 385                390                395                400
Arg Leu Phe Thr Arg Leu Arg His Glu Phe His Lys Trp Ser Thr Ile 
                 405                410                415
Ile Glu Asn Asn Phe Gln Glu Gly His Lys Ile Leu Ser Arg Lys Ile 
             420                425                430
Gln Lys Phe Glu Asn Gln Tyr Arg Gly Arg Glu Leu Pro Gly Phe Val 
         435                440                445
Asn Tyr Arg Thr Phe Glu Thr Ile Val Lys Gln Gln Ile Lys Ala Leu 
     450                455                460
Glu Glu Pro Ala Val Asp Met Leu His Thr Val Thr Asp Met Val Arg 
 465                470                475                480
Leu Ala Phe Thr Asp Val Ser Ile Lys Asn Phe Glu Glu Phe Phe Asn 
                 485                490                495
Leu His Arg Thr Ala Lys Ser Lys Ile Glu Asp Ile Arg Ala Glu Gln 
             500                505                510
Glu Arg Glu Gly Glu Lys Leu Ile Arg Leu His Phe Gln Met Glu Gln 
         515                520                525
Ile Val Tyr Cys Gln Asp Gln Val Tyr Arg Gly Ala Leu Gln Lys Val 
     530                535                540
Arg Glu Lys Glu Leu Glu Glu Glu Lys Lys Lys Lys Ser Trp Asp Phe 
 545                550                555                560
Gly Ala Phe Gln Ser Ser Ser Ala Thr Asp Ser Ser Met Glu Glu Ile 
                 565                570                575
Phe Gln His Leu Met Ala Tyr His Gln Glu Ala Ser Lys Arg Ile Ser 
             580                585                590
Ser His Ile Pro Leu Ile Ile Gln Phe Phe Met Leu Gln Thr Tyr Gly 
         595                600                605
Gln Gln Leu Gln Lys Ala Met Leu Gln Leu Leu Gln Asp Lys Asp Thr 
     610                615                620
Tyr Ser Trp Leu Leu Lys Glu Arg Ser Asp Thr Ser Asp Lys Arg Lys 
 625                630                635                640
Phe Leu Lys Glu Arg Leu Ala Arg Leu Thr Gln Ala Arg Arg Arg Leu 
                 645                650                655
Ala Gln Phe Pro Gly 
             660



<210> 9519
<211> 453
<212> DNA
<213> Rattus norvegicus
<308> X52733
<400> 9519

ccgccatgc  atccagact  aggaagacc  ggaaactcc  gggccacgt  agccacggc  60
acggtcgca  cggtaagca  cgcaagcac  caggaggcc  cgggaatgc  ggaggcatg  120
atcaccaca  gatcaactt  gacaaatat  atccaggtt  cttcggcaa  gttggcatg  180
ggcattacc  cttgaagag  aaccagagc  tctgcccaa  tgtcaacct  gataaatta  240
ggacgttgg  cagcgagca  acacgggtc  atgcagcaa  aaacaagaa  ggagttgct  300
ccatcattg  cgttgttcg  tcaggctac  acaaagttc  ggggaaggg  aagctccct  360
agcaacctg  catcgtgaa  gccaagttc  tcagcagaa  agctgaaga  aagataaag  420
gtgtgggag  tgcctgtgt  ctggtggct  aag  453



<210> 9520
<211> 147
<212> PRT
<213> Rattus norvegicus
<308> CAA36947
<400> 9520

Pro Ser Arg Leu Arg Lys Thr Arg Lys Leu Arg Gly His Val Ser His 
  1               5                  10                  15
Gly His Gly Arg Ile Gly Lys His Arg Lys His Pro Gly Gly Arg Gly 
             20                  25                  30
Asn Ala Gly Gly Met His His His Arg Ile Asn Phe Asp Lys Tyr His 
         35                  40                  45
Pro Gly Tyr Phe Gly Lys Val Gly Met Arg His Tyr His Leu Lys Arg 
     50                  55                  60
Asn Gln Ser Phe Cys Pro Thr Val Asn Leu Asp Lys Leu Trp Thr Leu 
 65                  70                  75                  80
Val Ser Glu Gln Thr Arg Val Asn Ala Ala Lys Asn Lys Asn Gly Val 
                 85                  90                  95
Ala Pro Ile Ile Asp Val Val Arg Ser Gly Tyr Tyr Lys Val Leu Gly 
             100                105                110
Lys Gly Lys Leu Pro Lys Gln Pro Val Ile Val Lys Ala Lys Phe Phe 
         115                120                125
Ser Arg Arg Ala Glu Glu Lys Ile Lys Gly Val Gly Gly Ala Cys Val 
     130                135                140
Leu Val Ala 
 145



<210> 9521
<211> 514
<212> DNA
<213> Homo sapiens
<308> NM_000990
<400> 9521

ctttttcgt  tgggctgcc  acatgccat  cagactgag  aagacccgg  aacttaggg  60
ccacgtgag  cacggccac  gccgcatag  caagcaccg  aagcacccc  gcggccgcg  120
taatgctgg  ggtctgcat  accaccgga  caacttcga  aaataccac  caggctact  180
tgggaaagt  ggtatgaag  attaccact  aaagaggaa  cagagcttc  gcccaactg  240
caaccttga  aaattgtgg  ctttggtca  tgaacagac  cgggtgaat  ctgctaaaa  300
caagactgg  gctgctccc  tcattgatg  ggtgcgatc  ggctactac  aagttctgg  360
aaagggaaa  ctcccaaag  agcctgtca  cgtgaaggc  aaattcttc  gcagaagag  420
tgaggagaa  attaagagt  ttggggggg  ctgtgtcct  gtggcttga  gccacatgg  480
gggagtttc  ttaaatgct  actactttt  aaaa  514



<210> 9522
<211> 147
<212> PRT
<213> Homo sapiens
<308> P46776
<400> 9522

Pro Ser Arg Leu Arg Lys Thr Arg Lys Leu Arg Gly His Val Ser His 
  1               5                  10                  15
Gly His Gly Arg Ile Gly Lys His Arg Lys His Pro Gly Gly Arg Gly 
             20                  25                  30
Asn Ala Gly Gly Leu His His His Arg Ile Asn Phe Asp Lys Tyr His 
         35                  40                  45
Pro Gly Tyr Phe Gly Lys Val Gly Met Lys His Tyr His Leu Lys Arg 
     50                  55                  60
Asn Gln Ser Phe Cys Pro Thr Val Asn Leu Asp Lys Leu Trp Thr Leu 
 65                  70                  75                  80
Val Ser Glu Gln Thr Arg Val Asn Ala Ala Lys Asn Lys Thr Gly Ala 
                 85                  90                  95
Ala Pro Ile Ile Asp Val Val Arg Ser Gly Tyr Tyr Lys Val Leu Gly 
             100                105                110
Lys Gly Lys Leu Pro Lys Gln Pro Val Ile Val Lys Ala Lys Phe Phe 
         115                120                125
Ser Arg Arg Ala Glu Glu Lys Ile Lys Ser Val Gly Gly Ala Cys Val 
     130                135                140
Leu Val Ala 
 145



<210> 9523
<211> 1473
<212> DNA
<213> Rattus norvegicus
<308> X52817
<400> 9523

cccaccgcc  ccgcagccg  gcagcgacg  agagtgcaa  ctcagcgac  ggaggagag  60
cacgagccc  ccaagcccg  accatgcag  cactgccga  tccaccaag  tggactgtg  120
gtggagcaa  tggaaaagt  aggctattg  ccttctgta  tggcgggac  tcaagcaga  180
ggggattgt  ttcgggagc  tcctgctgc  gctcttctc  ctgacccag  tcagcgttg  240
gagcgtcgt  gcctacctg  ccctggctg  cctctctgc  accatcagc  tccgcatct  300
caagtccgt  ctacaagct  tgcagaaaa  agatgaggg  caccctttc  aggcctacc  360
ggagctgga  atcaccctg  cccaggagc  gatccagaa  tacacagac  gcctgcagc  420
atacgtgaa  agcactctg  aggagctac  gaggctctt  cttgtccaa  acctagtgg  480
ttccttaaa  tttgcagtc  tcatgtggc  cctgaccta  gttggcgca  tcttcaatg  540
cctgaccct  ctgcttatg  ctgtggttt  gatgtttac  ctacctgtg  tatatgtta  600
gcaccaggc  caggttgac  aatatctgg  acttgtgag  actcacata  acaccgttg  660
ggcaaagat  caggctaaa  tccccggcg  aagaggcat  ctgagtaga  ggttgcccc  720
ggagaagcc  gacatgaat  ggggtgtct  gagtggtaa  agctctctc  ttcctcgtt  780
ctgcgaatt  attgtttcc  ttccccagt  ccataatct  agaggcaaa  ttcgagaca  840
gtgttttca  tcttttcct  tactcttag  atatttgag  cccccccgc  ccttgtcaa  900
cactaaagt  tagagtgtg  tagatgtgg  ttttaattt  gtgttgcta  aaaaaaaaa  960
agtgcatga  ggtgagagc  cacgttctc  ttcgtccct  gctgtcctc  ccctgcaat  1020
cttctgtgg  ttctactgt  cctgtggct  ggcccttct  gccaagtgc  ctgacacat  1080
gtgggtcgc  tatcatgtc  ttgggttgc  ggttggatt  atctctaat  acactatat  1140
gaatcatag  ccaatgttt  agcatttta  ccccccaca  acagaacat  aaaattaat  1200
taaaacagt  gaccgtgta  atggtgatc  gttttgtat  actaagaat  atcgaatta  1260
agaataaat  caaaaatga  cgcacagta  ttttattgt  tgggatgcc  gggctgatt  1320
acatgtatg  taactaaag  gccagcatg  tgactttat  acgatttgt  tttcttcct  1380
tgtagttcc  aacggactc  atcacagac  ctgggtatt  gcacttatg  acttgatac  1440
agaatgcac  aataaatgt  actcaaatg  aaa  1473



<210> 9524
<211> 267
<212> PRT
<213> Rattus norvegicus
<308> CAA37001
<400> 9524

Met Asp Cys Val Trp Ser Asn Trp Lys Ser Gln Ala Ile Asp Leu Leu 
  1               5                  10                  15
Tyr Trp Arg Asp Ile Lys Gln Thr Gly Ile Val Phe Gly Ser Phe Leu 
             20                  25                  30
Leu Leu Leu Phe Ser Leu Thr Gln Phe Ser Val Val Ser Val Val Ala 
         35                  40                  45
Tyr Leu Ala Leu Ala Ala Leu Ser Ala Thr Ile Ser Phe Arg Ile Tyr 
     50                  55                  60
Lys Ser Val Leu Gln Ala Val Gln Lys Thr Asp Glu Gly His Pro Phe 
 65                  70                  75                  80
Lys Ala Tyr Leu Glu Leu Glu Ile Thr Leu Ser Gln Glu Gln Ile Gln 
                 85                  90                  95
Lys Tyr Thr Asp Cys Leu Gln Leu Tyr Val Asn Ser Thr Leu Lys Glu 
             100                105                110
Leu Arg Arg Leu Phe Leu Val Gln Asp Leu Val Asp Ser Leu Lys Phe 
         115                120                125
Ala Val Leu Met Trp Leu Leu Thr Tyr Val Gly Ala Leu Phe Asn Gly 
     130                135                140
Leu Thr Leu Leu Leu Met Ala Val Val Ser Met Phe Thr Leu Pro Val 
 145                150                155                160
Val Tyr Val Lys His Gln Ala Gln Val Asp Gln Tyr Leu Gly Leu Val 
                 165                170                175
Arg Thr His Ile Asn Thr Val Val Ala Lys Ile Gln Ala Lys Ile Pro 
             180                185                190
Gly Ala Arg Gly Met Leu Ser Arg Trp Leu Pro Gln Glu Lys Pro Asp 
         195                200                205
Met Asn Gly Gly Val Trp Ser Gly Asn Ser Ser Leu Leu Pro Arg Tyr 
     210                215                220
Cys Glu Leu Ile Val Ser Leu Pro Gln Tyr His Asn Leu Arg Gly Lys 
 225                230                235                240
Leu Arg Asp Arg Cys Phe Gln Ser Phe Pro Val Leu Leu Gly Tyr Leu 
                 245                250                255
Ser Pro Pro Arg Pro Leu Ser Ser Thr Lys Val 
             260                265



<210> 9525
<211> 1139
<212> DNA
<213> Rattus norvegicus
<308> X52840
<400> 9525

agatttgaa  cgccaccat  tcgagcaaa  aagcaaaga  caagaccac  aaaaagcgc  60
ctcagcgcg  aacgtccaa  gtgttcgcc  tgtttgacc  gtcccagat  caggagttc  120
aagaggcct  caacatgat  gaccagaac  gggacggct  cattgacaa  gaggaccta  180
acgacatgc  cgcgtctct  gggaagaac  ccaccgacg  ctacctgga  gccatgatg  240
acgaggccc  gggccgcat  aatttcacc  tgttcctca  catgtttgg  gagaagctg  300
acggcaccg  cccagagga  gtcatcaga  acgccttcg  ttgcttcga  gaggaagcc  360
caggcacca  ccaggagga  tacctgagg  agctgctga  caccatggg  gaccgcttc  420
cagatgagg  agtggatga  ctgtacagg  aggccccca  cgacaaaaa  ggcaatttc  480
actacatcg  gttcacgcg  atcctcaag  acggagcga  agacaaaga  gactgaaga  540
gctgcagct  acattcctg  tgagtttcc  tattcactt  atgtctcag  cacagcccc  600
ataggacct  ctgtgtgcc  ctttgtgtc  ctcagacac  ccctcccat  ggcctactg  660
gtgccgctt  gtccctcag  caccccctc  cataggcct  ctgtgtgcc  cttagtccc  720
cagacaccc  ctcccatag  cctactgtg  gccatttgt  cctcagaca  cccctccca  780
aggacctac  gtgtaccac  tggtttctc  gacagcccc  cccccaaac  cccctaagg  840
cctactgcg  gccacttag  ttcacagcc  ttccttttt  taatgtatt  attccagac  900
ctttctgcc  cttagcatg  gtataatca  actggaatg  ggacaatgt  gtaattgta  960
tgaaaatga  atgcaaata  aaaaatcaa  caatgtgaa  gcccaggaa  atatatcgg  1020
atttctggt  ttgctggat  tttttacat  tttatataa  aaaaatgtt  ttttgaaat  1080
aagattatg  tgactcaag  tggagtata  aacaaaaaa  aaaaaaaaa  aaaaaaaaa  1139



<210> 9526
<211> 171
<212> PRT
<213> Rattus norvegicus
<308> P18666
<400> 9526

Ser Ser Lys Lys Ala Lys Thr Lys Thr Thr Lys Lys Arg Pro Gln Arg 
  1               5                  10                  15
Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln Glu 
             20                  25                  30
Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe Ile 
         35                  40                  45
Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn Pro 
     50                  55                  60
Thr Asp Ala Tyr Leu Asp Ala Met Met Asn Glu Ala Pro Gly Arg Ile 
 65                  70                  75                  80
Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly Thr 
                 85                  90                  95
Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu Glu 
             100                105                110
Ala Thr Gly Thr Ile Gln Glu Asp Tyr Leu Arg Glu Leu Leu Thr Thr 
         115                120                125
Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Leu Tyr Arg Glu 
     130                135                140
Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Ile Glu Phe Thr Arg 
 145                150                155                160
Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
                 165                170



<210> 9527
<211> 944
<212> DNA
<213> Homo sapiens
<308> X54304
<400> 9527

gcggccagc  cgtggtttt  agcggctct  tgggtagca  ggtggtgtg  tagcggccg  60
gggctcgga  gggtgctcg  attctcgta  ctgtgccgg  acttaacca  caccatgtc  120
agcaaaaga  caaagacca  gaccaagaa  cgccctcag  gtgcaacat  caatgtgtt  180
gctatgttt  accagtcac  gattcagga  ttcaaagag  ccttcaaca  gattgatca  240
aacagagat  gtttcatcg  caaggaaga  ttgcatgat  tgcttgctt  attggggaa  300
aatccaact  atgagtatc  agatgccat  atgaatgag  ctccaggcc  catcaattt  360
accatgttc  tcaccatgt  tggtgagaa  ttaaatggc  cagatcctg  agatgtcat  420
agaaatgcc  ttgcttgct  tgatgaaga  gcaactggc  ccatacagg  agattactt  480
agagagctg  tgacaacca  gggggatcg  tttacagat  aggaagtgg  tgagctgta  540
agagaagca  ctattgata  aaaggggaa  ttcaattac  tcgagttca  acgcatcct  600
aaacatgga  ccaaagaca  agatgactg  aataacttc  aattccagc  aacgtcctt  660
ttgcacttt  ggtattctg  gattttctc  tgccattcc  ttaggcttt  gcagctttg  720
atttcctgt  gtatttatt  tcagccatt  tgggcatat  tatctttat  atcagactg  780
aaacgggac  ttctattaa  atcattttc  gaataaaaa  taggataat  taacctacc  840
gcccttctc  cccaataac  gtgggtcta  acagagtca  tatattttt  cagagaaag  900
tagttcggc  cgatttttt  tgaatcata  ttaaacttt  ttgc  944



<210> 9528
<211> 170
<212> PRT
<213> Homo sapiens
<308> P19105
<400> 9528

Ser Ser Lys Arg Thr Lys Thr Lys Thr Lys Lys Arg Pro Gln Arg Ala 
  1               5                  10                  15
Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln Glu Phe 
             20                  25                  30
Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe Ile Asp 
         35                  40                  45
Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn Pro Thr 
     50                  55                  60
Asp Glu Tyr Leu Asp Ala Met Met Asn Glu Ala Pro Gly Pro Ile Asn 
 65                  70                  75                  80
Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly Thr Asp 
                 85                  90                  95
Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu Glu Ala 
             100                105                110
Thr Gly Thr Ile Gln Glu Asp Tyr Leu Arg Glu Leu Leu Thr Thr Met 
         115                120                125
Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Leu Tyr Arg Glu Ala 
     130                135                140
Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Ile Glu Phe Thr Arg Ile 
 145                150                155                160
Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
                 165                170



<210> 9529
<211> 936
<212> DNA
<213> Rattus norvegicus
<308> X53052
<400> 9529

gaacttcgg  ctgcctcct  ttggagggc  atatttgct  agttctttg  taccctctt  60
tatgtcttc  ttgggctgg  atcctcact  cgttgggcc  ctggacccc  acatgtcct  120
caagtggct  tggcctttg  cctggccct  gccacactg  tgcagactg  gggtcacat  180
agtggagcc  atgtcaacc  tgcggtcac  tttgccttc  ttgtgggct  ccagatgtc  240
ttgctccgt  ctttctgct  tatagcagc  cagcttctg  gagctgtgg  tggagcggc  300
gtgctgtac  gtgtcaccc  accagctgt  cgaggaaac  tagcactca  cacgctgca  360
gctggggta  gcgtgggcc  ggccaccac  gtggagatc  tcctgacgc  ccagttcgt  420
ctctgcatc  ttgctacgt  tgacgagag  cggaatggc  gcatgggct  tgtggccct  480
gctgttggc  tctccctca  cctggggca  ctctttggg  tgtattaca  tggcgcggg  540
atgaatccc  cccgctcct  tgctcctgc  atcctcacc  gaaacttca  caaccactg  600
gtgtactgg  tgggcccaa  catcggcgg  ggcctgggt  gcctgctct  cgactttct  660
ctcttccca  ggctcaaga  tgtttctga  agactgtct  tcctcaagg  agccagacc  720
agtgactcc  atggacagc  agagggtac  ggggaacct  tggaactga  gactcaggc  780
ctgtaaaag  tgcagaacg  cgctgggtt  cagggaggc  caagccagc  cttggatga  840
gaaagagac  gtggggagg  ggatcaatc  gtacttctt  attttttaa  ttacgtttt  900
cattttttc  ttttgctgt  tgaaatctt  caagtt  936



<210> 9530
<211> 261
<212> PRT
<213> Rattus norvegicus
<308> CAA37219
<400> 9530

Glu Leu Arg Ser Ala Ser Phe Trp Arg Ala Ile Phe Ala Glu Phe Phe 
  1               5                  10                  15
Ala Thr Leu Phe Tyr Val Phe Phe Gly Leu Gly Ser Ser Leu Arg Trp 
             20                  25                  30
Ala Pro Gly Pro Leu His Val Leu Gln Val Ala Leu Ala Phe Gly Leu 
         35                  40                  45
Ala Leu Ala Thr Leu Val Gln Thr Val Gly His Ile Ser Gly Ala His 
     50                  55                  60
Val Asn Pro Ala Val Thr Phe Ala Phe Leu Val Gly Ser Gln Met Ser 
 65                  70                  75                  80
Leu Leu Arg Ala Phe Cys Tyr Ile Ala Ala Gln Leu Leu Gly Ala Val 
                 85                  90                  95
Ala Gly Ala Ala Val Leu Tyr Ser Val Thr Pro Pro Ala Val Arg Gly 
             100                105                110
Asn Leu Ala Leu Asn Thr Leu His Ala Gly Val Ser Val Gly Gln Ala 
         115                120                125
Thr Thr Val Glu Ile Phe Leu Thr Leu Gln Phe Val Leu Cys Ile Phe 
     130                135                140
Ala Thr Tyr Asp Glu Arg Arg Asn Gly Arg Met Gly Ser Val Ala Leu 
 145                150                155                160
Ala Val Gly Phe Ser Leu Thr Leu Gly His Leu Phe Gly Met Tyr Tyr 
                 165                170                175
Thr Gly Ala Gly Met Asn Pro Ala Arg Ser Phe Ala Pro Ala Ile Leu 
             180                185                190
Thr Arg Asn Phe Ser Asn His Trp Val Tyr Trp Val Gly Pro Ile Ile 
         195                200                205
Gly Gly Gly Leu Gly Ser Leu Leu Tyr Asp Phe Leu Leu Phe Pro Arg 
     210                215                220
Leu Lys Ser Val Ser Glu Arg Leu Ser Ile Leu Lys Gly Ala Arg Pro 
 225                230                235                240
Ser Asp Ser Asn Gly Gln Pro Glu Gly Thr Gly Glu Pro Val Glu Leu 
                 245                250                255
Lys Thr Gln Ala Leu 
             260



<210> 9531
<211> 1019
<212> DNA
<213> Homo sapiens
<308> NM_012064
<400> 9531

catgggggt  gcagggacc  aggcactgt  accatcccc  ctgccatgt  ggaactgcg  60
tcagcctcc  tttggaggg  catattcgc  gagttcttt  ccaccctct  ctatgtctt  120
tttgggctg  ggtcctcac  gcgctgggc  cctggaccc  tgcatgttc  gcaggtggc  180
atggcattt  gcttggccc  ggctacact  gtgcagtct  tgggccaca  cagtggagc  240
cacgtcaat  ctgcagtca  ttttgcttt  cttgtgggc  cccagatgt  cctgctccg  300
gccttctgc  atatggcag  ccagctcct  ggagctgtg  ctggggccg  tgtgctgta  360
agcgttacc  cacctgctg  ccgaggaaa  ctagcactc  acacgttgc  ccctgcggt  420
agcgtgggc  aggcaacca  agtggagat  ttcctgacg  tccagttcg  gctctgcat  480
tttgccaca  acgacgaga  gcggaatgg  caactgggc  ccgtggccc  ggccgttgg  540
ttctccctt  ccctggggc  cctctttgg  atgtattat  ctggtgcag  catgaatcc  600
gcccgctcc  ttgctcctg  cattctcac  gggaacttc  ctaaccact  ggtgtactg  660
gtaggccca  tcattggag  gggtctggg  agcctcctg  acgactttc  tctcttccc  720
cggctcaag  gtatttctg  gagactgtc  gtcctcaag  gtgccaaac  cgatgtctc  780
aatggacaa  cagaggtca  aggggaacc  gttgaactg  acacccagg  cctgtagaa  840
ctccagctg  atagaggga  tagaaagct  ctgagttta  gtggagggg  ttagccagc  900
cctagatga  gaaagagac  gtggggagg  gcatgtact  ctttatttt  taacttatg  960
atgtggttg  ttttttttt  tttttcctt  tgctgtgtg  aatctttca  gttgcattc  1019



<210> 9532
<211> 263
<212> PRT
<213> Homo sapiens
<308> NP_036196
<400> 9532

Met Trp Glu Leu Arg Ser Ala Ser Phe Trp Arg Ala Ile Phe Ala Glu 
  1               5                  10                  15
Phe Phe Ala Thr Leu Phe Tyr Val Phe Phe Gly Leu Gly Ser Ser Leu 
             20                  25                  30
Arg Trp Ala Pro Gly Pro Leu His Val Leu Gln Val Ala Met Ala Phe 
         35                  40                  45
Gly Leu Ala Leu Ala Thr Leu Val Gln Ser Val Gly His Ile Ser Gly 
     50                  55                  60
Ala His Val Asn Pro Ala Val Thr Phe Ala Phe Leu Val Gly Ser Gln 
 65                  70                  75                  80
Met Ser Leu Leu Arg Ala Phe Cys Tyr Met Ala Ala Gln Leu Leu Gly 
                 85                  90                  95
Ala Val Ala Gly Ala Ala Val Leu Tyr Ser Val Thr Pro Pro Ala Val 
             100                105                110
Arg Gly Asn Leu Ala Leu Asn Thr Leu His Pro Ala Val Ser Val Gly 
         115                120                125
Gln Ala Thr Thr Val Glu Ile Phe Leu Thr Leu Gln Phe Val Leu Cys 
     130                135                140
Ile Phe Ala Thr Tyr Asp Glu Arg Arg Asn Gly Gln Leu Gly Ser Val 
 145                150                155                160
Ala Leu Ala Val Gly Phe Ser Leu Ala Leu Gly His Leu Phe Gly Met 
                 165                170                175
Tyr Tyr Thr Gly Ala Gly Met Asn Pro Ala Arg Ser Phe Ala Pro Ala 
             180                185                190
Ile Leu Thr Gly Asn Phe Thr Asn His Trp Val Tyr Trp Val Gly Pro 
         195                200                205
Ile Ile Gly Gly Gly Leu Gly Ser Leu Leu Tyr Asp Phe Leu Leu Phe 
     210                215                220
Pro Arg Leu Lys Ser Ile Ser Glu Arg Leu Ser Val Leu Lys Gly Ala 
 225                230                235                240
Lys Pro Asp Val Ser Asn Gly Gln Pro Glu Val Thr Gly Glu Pro Val 
                 245                250                255
Glu Leu Asn Thr Gln Ala Leu 
             260



<210> 9533
<211> 1197
<212> DNA
<213> Rattus norvegicus
<308> X53054
<400> 9533

ctccttttc  ccagcatgg  gtggctcgc  agagattcc  gtgtggcag  tgtgatcct  60
ctgctgaca  tgctgagcc  tcccgtggc  ttggtcaga  accccacgc  acgattttt  120
gaacaagtt  aaggtgagt  tcatttcta  aacgggacg  agcgagtcc  gtttctggc  180
agatacatc  acaaccggg  ggagtacac  cgcttcgac  gcgacgtgg  cgagttccg  240
gcggtgacc  agctggggc  gccctcagc  gagtactat  acaaacaga  ggagtacat  300
gagcagttg  gggccacgg  ggacacggc  tgcaaacac  actacgaga  ctctgagag  360
ttccttgtt  cgcggacag  tgagcccaa  gtgactgtg  acccttcaa  gacgcagcc  420
ctggaacac  acaacctcc  ggtctgctc  gtgagtgac  tctaccctg  cagcgttga  480
gtcagatgg  tccggaatg  cgaggagga  aaggatgga  tcgtgtcca  cggcctgat  540
cgaaatgga  actggacct  ccagttgct  gtgatgctg  agacggttc  tcaaggtgg  600
gaggtttat  cctgccagg  ggagcatcc  agcctgccc  gccctgtca  agtggagtg  660
aaagcacag  ccacatctg  acaaaataa  aagatgagt  gagtcgggg  catcgtgct  720
ggtctgctc  tccttggag  tgggctgtt  gtctacttc  ggaaccaga  aggacagtc  780
ggacttcag  caacaggac  cctgaactg  ggtgaggcg  caaggctga  ggaaggcgt  840
ctcccagtg  caccatgtc  tgaaacatg  cctgcttgg  ccacattcc  ccagagaca  900
tgctctccc  gacctggct  ctcctgatt  tccaccccg  agatctgtg  tcctggtgg  960
tgtttagcc  ctggccaaa  cttgcagcc  cggggacag  agccccctc  ctcaccact  1020
ctgctccct  ttgtccctt  ccctttgcc  ggcgcttct  agtcagtct  ctgtcatat  1080
ctttctgac  tctttctca  ataaacaaa  aatgaaagt  atctacttc  gagtttcaa  1140
cagaagaaa  accattcat  catagtaag  atgggggat  gtgtataag  aataaat  1197



<210> 9534
<211> 264
<212> PRT
<213> Rattus norvegicus
<308> P18211
<400> 9534

Met Val Trp Leu Ala Arg Asp Ser Cys Val Ala Ala Val Ile Leu Leu 
  1               5                  10                  15
Leu Thr Val Leu Ser Pro Pro Val Ala Leu Val Arg Asp Pro Thr Pro 
             20                  25                  30
Arg Phe Leu Glu Gln Val Lys Gly Glu Cys His Phe Tyr Asn Gly Thr 
         35                  40                  45
Gln Arg Val Arg Phe Leu Ala Arg Tyr Ile Tyr Asn Arg Glu Glu Tyr 
     50                  55                  60
Thr Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
 65                  70                  75                  80
Gly Arg Pro Ser Ala Glu Tyr Tyr Asn Lys Gln Lys Glu Tyr Met Glu 
                 85                  90                  95
Gln Leu Arg Ala Thr Val Asp Thr Ala Cys Lys His Asp Tyr Glu Ile 
             100                105                110
Ser Glu Ser Phe Leu Val Pro Arg Thr Val Glu Pro Lys Val Thr Val 
         115                120                125
Tyr Pro Ser Lys Thr Gln Pro Leu Glu His His Asn Leu Leu Val Cys 
     130                135                140
Ser Val Ser Asp Phe Tyr Pro Gly Ser Val Glu Val Arg Trp Phe Arg 
 145                150                155                160
Asn Gly Glu Glu Glu Lys Asp Gly Leu Val Ser Thr Gly Leu Ile Arg 
                 165                170                175
Asn Gly Asp Trp Thr Phe Gln Leu Leu Val Met Leu Glu Thr Val Pro 
             180                185                190
Gln Gly Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Leu Pro 
         195                200                205
Ser Pro Val Arg Val Glu Trp Lys Ala Gln Ser Thr Ser Ala Gln Asn 
     210                215                220
Lys Lys Met Ser Gly Val Gly Gly Ile Val Leu Gly Leu Leu Phe Leu 
 225                230                235                240
Gly Ala Gly Leu Phe Val Tyr Phe Arg Asn Gln Lys Gly Gln Ser Gly 
                 245                250                255
Leu Gln Pro Thr Gly Leu Leu Asn 
             260



<210> 9535
<211> 1197
<212> DNA
<213> Rattus norvegicus
<308> X53054
<400> 9535

ctccttttc  ccagcatgg  gtggctcgc  agagattcc  gtgtggcag  tgtgatcct  60
ctgctgaca  tgctgagcc  tcccgtggc  ttggtcaga  accccacgc  acgattttt  120
gaacaagtt  aaggtgagt  tcatttcta  aacgggacg  agcgagtcc  gtttctggc  180
agatacatc  acaaccggg  ggagtacac  cgcttcgac  gcgacgtgg  cgagttccg  240
gcggtgacc  agctggggc  gccctcagc  gagtactat  acaaacaga  ggagtacat  300
gagcagttg  gggccacgg  ggacacggc  tgcaaacac  actacgaga  ctctgagag  360
ttccttgtt  cgcggacag  tgagcccaa  gtgactgtg  acccttcaa  gacgcagcc  420
ctggaacac  acaacctcc  ggtctgctc  gtgagtgac  tctaccctg  cagcgttga  480
gtcagatgg  tccggaatg  cgaggagga  aaggatgga  tcgtgtcca  cggcctgat  540
cgaaatgga  actggacct  ccagttgct  gtgatgctg  agacggttc  tcaaggtgg  600
gaggtttat  cctgccagg  ggagcatcc  agcctgccc  gccctgtca  agtggagtg  660
aaagcacag  ccacatctg  acaaaataa  aagatgagt  gagtcgggg  catcgtgct  720
ggtctgctc  tccttggag  tgggctgtt  gtctacttc  ggaaccaga  aggacagtc  780
ggacttcag  caacaggac  cctgaactg  ggtgaggcg  caaggctga  ggaaggcgt  840
ctcccagtg  caccatgtc  tgaaacatg  cctgcttgg  ccacattcc  ccagagaca  900
tgctctccc  gacctggct  ctcctgatt  tccaccccg  agatctgtg  tcctggtgg  960
tgtttagcc  ctggccaaa  cttgcagcc  cggggacag  agccccctc  ctcaccact  1020
ctgctccct  ttgtccctt  ccctttgcc  ggcgcttct  agtcagtct  ctgtcatat  1080
ctttctgac  tctttctca  ataaacaaa  aatgaaagt  atctacttc  gagtttcaa  1140
cagaagaaa  accattcat  catagtaag  atgggggat  gtgtataag  aataaat  1197



<210> 9536
<211> 264
<212> PRT
<213> Rattus norvegicus
<308> P18211
<400> 9536

Met Val Trp Leu Ala Arg Asp Ser Cys Val Ala Ala Val Ile Leu Leu 
  1               5                  10                  15
Leu Thr Val Leu Ser Pro Pro Val Ala Leu Val Arg Asp Pro Thr Pro 
             20                  25                  30
Arg Phe Leu Glu Gln Val Lys Gly Glu Cys His Phe Tyr Asn Gly Thr 
         35                  40                  45
Gln Arg Val Arg Phe Leu Ala Arg Tyr Ile Tyr Asn Arg Glu Glu Tyr 
     50                  55                  60
Thr Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
 65                  70                  75                  80
Gly Arg Pro Ser Ala Glu Tyr Tyr Asn Lys Gln Lys Glu Tyr Met Glu 
                 85                  90                  95
Gln Leu Arg Ala Thr Val Asp Thr Ala Cys Lys His Asp Tyr Glu Ile 
             100                105                110
Ser Glu Ser Phe Leu Val Pro Arg Thr Val Glu Pro Lys Val Thr Val 
         115                120                125
Tyr Pro Ser Lys Thr Gln Pro Leu Glu His His Asn Leu Leu Val Cys 
     130                135                140
Ser Val Ser Asp Phe Tyr Pro Gly Ser Val Glu Val Arg Trp Phe Arg 
 145                150                155                160
Asn Gly Glu Glu Glu Lys Asp Gly Leu Val Ser Thr Gly Leu Ile Arg 
                 165                170                175
Asn Gly Asp Trp Thr Phe Gln Leu Leu Val Met Leu Glu Thr Val Pro 
             180                185                190
Gln Gly Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Leu Pro 
         195                200                205
Ser Pro Val Arg Val Glu Trp Lys Ala Gln Ser Thr Ser Ala Gln Asn 
     210                215                220
Lys Lys Met Ser Gly Val Gly Gly Ile Val Leu Gly Leu Leu Phe Leu 
 225                230                235                240
Gly Ala Gly Leu Phe Val Tyr Phe Arg Asn Gln Lys Gly Gln Ser Gly 
                 245                250                255
Leu Gln Pro Thr Gly Leu Leu Asn 
             260



<210> 9537
<211> 1197
<212> DNA
<213> Rattus norvegicus
<308> X53054
<400> 9537

ctccttttc  ccagcatgg  gtggctcgc  agagattcc  gtgtggcag  tgtgatcct  60
ctgctgaca  tgctgagcc  tcccgtggc  ttggtcaga  accccacgc  acgattttt  120
gaacaagtt  aaggtgagt  tcatttcta  aacgggacg  agcgagtcc  gtttctggc  180
agatacatc  acaaccggg  ggagtacac  cgcttcgac  gcgacgtgg  cgagttccg  240
gcggtgacc  agctggggc  gccctcagc  gagtactat  acaaacaga  ggagtacat  300
gagcagttg  gggccacgg  ggacacggc  tgcaaacac  actacgaga  ctctgagag  360
ttccttgtt  cgcggacag  tgagcccaa  gtgactgtg  acccttcaa  gacgcagcc  420
ctggaacac  acaacctcc  ggtctgctc  gtgagtgac  tctaccctg  cagcgttga  480
gtcagatgg  tccggaatg  cgaggagga  aaggatgga  tcgtgtcca  cggcctgat  540
cgaaatgga  actggacct  ccagttgct  gtgatgctg  agacggttc  tcaaggtgg  600
gaggtttat  cctgccagg  ggagcatcc  agcctgccc  gccctgtca  agtggagtg  660
aaagcacag  ccacatctg  acaaaataa  aagatgagt  gagtcgggg  catcgtgct  720
ggtctgctc  tccttggag  tgggctgtt  gtctacttc  ggaaccaga  aggacagtc  780
ggacttcag  caacaggac  cctgaactg  ggtgaggcg  caaggctga  ggaaggcgt  840
ctcccagtg  caccatgtc  tgaaacatg  cctgcttgg  ccacattcc  ccagagaca  900
tgctctccc  gacctggct  ctcctgatt  tccaccccg  agatctgtg  tcctggtgg  960
tgtttagcc  ctggccaaa  cttgcagcc  cggggacag  agccccctc  ctcaccact  1020
ctgctccct  ttgtccctt  ccctttgcc  ggcgcttct  agtcagtct  ctgtcatat  1080
ctttctgac  tctttctca  ataaacaaa  aatgaaagt  atctacttc  gagtttcaa  1140
cagaagaaa  accattcat  catagtaag  atgggggat  gtgtataag  aataaat  1197



<210> 9538
<211> 264
<212> PRT
<213> Rattus norvegicus
<308> P18211
<400> 9538

Met Val Trp Leu Ala Arg Asp Ser Cys Val Ala Ala Val Ile Leu Leu 
  1               5                  10                  15
Leu Thr Val Leu Ser Pro Pro Val Ala Leu Val Arg Asp Pro Thr Pro 
             20                  25                  30
Arg Phe Leu Glu Gln Val Lys Gly Glu Cys His Phe Tyr Asn Gly Thr 
         35                  40                  45
Gln Arg Val Arg Phe Leu Ala Arg Tyr Ile Tyr Asn Arg Glu Glu Tyr 
     50                  55                  60
Thr Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
 65                  70                  75                  80
Gly Arg Pro Ser Ala Glu Tyr Tyr Asn Lys Gln Lys Glu Tyr Met Glu 
                 85                  90                  95
Gln Leu Arg Ala Thr Val Asp Thr Ala Cys Lys His Asp Tyr Glu Ile 
             100                105                110
Ser Glu Ser Phe Leu Val Pro Arg Thr Val Glu Pro Lys Val Thr Val 
         115                120                125
Tyr Pro Ser Lys Thr Gln Pro Leu Glu His His Asn Leu Leu Val Cys 
     130                135                140
Ser Val Ser Asp Phe Tyr Pro Gly Ser Val Glu Val Arg Trp Phe Arg 
 145                150                155                160
Asn Gly Glu Glu Glu Lys Asp Gly Leu Val Ser Thr Gly Leu Ile Arg 
                 165                170                175
Asn Gly Asp Trp Thr Phe Gln Leu Leu Val Met Leu Glu Thr Val Pro 
             180                185                190
Gln Gly Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Leu Pro 
         195                200                205
Ser Pro Val Arg Val Glu Trp Lys Ala Gln Ser Thr Ser Ala Gln Asn 
     210                215                220
Lys Lys Met Ser Gly Val Gly Gly Ile Val Leu Gly Leu Leu Phe Leu 
 225                230                235                240
Gly Ala Gly Leu Phe Val Tyr Phe Arg Asn Gln Lys Gly Gln Ser Gly 
                 245                250                255
Leu Gln Pro Thr Gly Leu Leu Asn 
             260



<210> 9539
<211> 1197
<212> DNA
<213> Rattus norvegicus
<308> X53054
<400> 9539

ctccttttc  ccagcatgg  gtggctcgc  agagattcc  gtgtggcag  tgtgatcct  60
ctgctgaca  tgctgagcc  tcccgtggc  ttggtcaga  accccacgc  acgattttt  120
gaacaagtt  aaggtgagt  tcatttcta  aacgggacg  agcgagtcc  gtttctggc  180
agatacatc  acaaccggg  ggagtacac  cgcttcgac  gcgacgtgg  cgagttccg  240
gcggtgacc  agctggggc  gccctcagc  gagtactat  acaaacaga  ggagtacat  300
gagcagttg  gggccacgg  ggacacggc  tgcaaacac  actacgaga  ctctgagag  360
ttccttgtt  cgcggacag  tgagcccaa  gtgactgtg  acccttcaa  gacgcagcc  420
ctggaacac  acaacctcc  ggtctgctc  gtgagtgac  tctaccctg  cagcgttga  480
gtcagatgg  tccggaatg  cgaggagga  aaggatgga  tcgtgtcca  cggcctgat  540
cgaaatgga  actggacct  ccagttgct  gtgatgctg  agacggttc  tcaaggtgg  600
gaggtttat  cctgccagg  ggagcatcc  agcctgccc  gccctgtca  agtggagtg  660
aaagcacag  ccacatctg  acaaaataa  aagatgagt  gagtcgggg  catcgtgct  720
ggtctgctc  tccttggag  tgggctgtt  gtctacttc  ggaaccaga  aggacagtc  780
ggacttcag  caacaggac  cctgaactg  ggtgaggcg  caaggctga  ggaaggcgt  840
ctcccagtg  caccatgtc  tgaaacatg  cctgcttgg  ccacattcc  ccagagaca  900
tgctctccc  gacctggct  ctcctgatt  tccaccccg  agatctgtg  tcctggtgg  960
tgtttagcc  ctggccaaa  cttgcagcc  cggggacag  agccccctc  ctcaccact  1020
ctgctccct  ttgtccctt  ccctttgcc  ggcgcttct  agtcagtct  ctgtcatat  1080
ctttctgac  tctttctca  ataaacaaa  aatgaaagt  atctacttc  gagtttcaa  1140
cagaagaaa  accattcat  catagtaag  atgggggat  gtgtataag  aataaat  1197



<210> 9540
<211> 264
<212> PRT
<213> Rattus norvegicus
<308> P18211
<400> 9540

Met Val Trp Leu Ala Arg Asp Ser Cys Val Ala Ala Val Ile Leu Leu 
  1               5                  10                  15
Leu Thr Val Leu Ser Pro Pro Val Ala Leu Val Arg Asp Pro Thr Pro 
             20                  25                  30
Arg Phe Leu Glu Gln Val Lys Gly Glu Cys His Phe Tyr Asn Gly Thr 
         35                  40                  45
Gln Arg Val Arg Phe Leu Ala Arg Tyr Ile Tyr Asn Arg Glu Glu Tyr 
     50                  55                  60
Thr Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
 65                  70                  75                  80
Gly Arg Pro Ser Ala Glu Tyr Tyr Asn Lys Gln Lys Glu Tyr Met Glu 
                 85                  90                  95
Gln Leu Arg Ala Thr Val Asp Thr Ala Cys Lys His Asp Tyr Glu Ile 
             100                105                110
Ser Glu Ser Phe Leu Val Pro Arg Thr Val Glu Pro Lys Val Thr Val 
         115                120                125
Tyr Pro Ser Lys Thr Gln Pro Leu Glu His His Asn Leu Leu Val Cys 
     130                135                140
Ser Val Ser Asp Phe Tyr Pro Gly Ser Val Glu Val Arg Trp Phe Arg 
 145                150                155                160
Asn Gly Glu Glu Glu Lys Asp Gly Leu Val Ser Thr Gly Leu Ile Arg 
                 165                170                175
Asn Gly Asp Trp Thr Phe Gln Leu Leu Val Met Leu Glu Thr Val Pro 
             180                185                190
Gln Gly Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser Leu Pro 
         195                200                205
Ser Pro Val Arg Val Glu Trp Lys Ala Gln Ser Thr Ser Ala Gln Asn 
     210                215                220
Lys Lys Met Ser Gly Val Gly Gly Ile Val Leu Gly Leu Leu Phe Leu 
 225                230                235                240
Gly Ala Gly Leu Phe Val Tyr Phe Arg Asn Gln Lys Gly Gln Ser Gly 
                 245                250                255
Leu Gln Pro Thr Gly Leu Leu Asn 
             260



<210> 9541
<211> 689
<212> DNA
<213> Rattus norvegicus
<308> X53231
<400> 9541

tcaggtggg  acaagctgc  cttggcatg  cctatagcc  ccaaccaca  ccagaggga  60
ttgctgatg  accaggctt  ccactgtgt  tgtacatgg  aagaggatc  acctggaca  120
tagttccac  tgacctctg  ctgatggtt  ggaaaacaa  tttaattag  atcccttgg  180
cactgcaga  gggaaaatt  ggctgattt  tgtcccact  gaggataaa  gaagactta  240
gccagcgct  cagcttgtc  ggacacgcc  aatgtcgtt  ttcttagtg  aaattgatt  300
tgagtcttt  taattccag  agcgtcctt  atgacacag  ttcaaaaca  aacccaagt  360
ttttgagtt  tactccaac  tctgccatt  ccttaaatg  agaagccaa  ccttctctt  420
atggacttt  agagtggac  caaaggatc  cttgctgct  gatgacagt  gtgtcttgg  480
actgtccag  ccctttagg  aaggaaggg  ctgcagctg  atgaactgg  aagctgcta  540
cggggagga  ttagcgccc  caccctaaa  tcatccacc  gaattcggc  ccccagcaa  600
cctgactcc  tgccagcac  tccacggct  cttaccccg  caacctccc  tcccctgag  660
cctccctca  taaatgcaa  ctgtagcaa  689



<210> 9542
<211> 37
<212> PRT
<213> Rattus norvegicus
<308> P18889
<400> 9542

Met Pro Tyr Ser Leu Gln Pro Gln Pro Glu Gly Phe Ala Asp Val Pro 
  1               5                  10                  15
Gly Phe Pro Leu Cys Met Tyr Met Val Arg Gly Ser Thr Trp Thr Leu 
             20                  25                  30
Val Pro Pro Asp Leu 
         35



<210> 9543
<211> 2750
<212> DNA
<213> Rattus norvegicus
<308> X53565
<400> 9543

cagactaca  gatgcagtt  ctggttgcg  tgctcctgc  gagtgtcgc  gtggcgaga  60
ctctgccat  cgcttctaa  ccaaacaac  catcaagtg  aaataatcc  ccgattcaa  120
cttccacgc  cctgcctcc  ggggttgat  tttctcaac  ggtaaagac  aacagaccg  180
ctgatcaga  gctggagtc  gataaagaa  gccaggaca  gacggtggc  aggacttcg  240
catcagttt  cagtggggt  gaatctgcg  ccaatctca  tttggatga  tccaaaaag  300
accccgaaa  agcagatgc  aaattgaag  aaactttgc  gcagctttt  cctgtggac  360
ccaaacagg  aaagtcagg  cagaagttt  caaaagatt  aggcagccc  acaggaggt  420
attccgaca  taccacagg  ggtgattct  acaagacca  aggagttga  tctgacaag  480
catcaggag  tgattctaa  aagcccaca  gaagtgata  tgacaagcc  acaggaggt  540
attctaaca  gcccacctc  aaagtcccc  ccaatacag  gactccaaa  attgacaaa  600
tccagctaa  tgaaaaagg  cagaaacca  cacttattt  caaaactga  tctggggaa  660
aactggcag  ggactctga  ttctcttta  agccagaga  aggagataa  tcttcagag  720
ctactgaag  tgtggaaac  aaggagatt  aagagggtg  tacagagcc  gaagaaggt  780
cgccacttg  agaagagaa  gaaaaggtg  tgggccctt  ctccagtga  aaccaagag  840
ggacactta  agattctat  aaggatgag  aggatgacc  ttataagga  aattctgga  900
acaccagtg  agaaagcag  cacttcttt  cttatctgg  gaccgctgc  gttcttgtt  960
ctgtcctct  tattgctta  cacaacaaa  gaaagatta  tgcttttgc  ctggaagga  1020
aaagatcca  agtcactcg  aggccaaag  ccagtgact  ccaacgttt  aacctaaag  1080
tttgatttt  attttgtct  caagaacct  gtcctccct  ctgatttgt  tccgaatca  1140
gagaaatga  aagactgac  tgtggggtt  ggtggcaag  ctgggctgg  agagatggg  1200
ttgcttcag  ttttgcacc  gcactttga  gacagtcct  tggtggtgt  ttatttact  1260
ttgtgttcc  tttatgtga  gtgtccatc  tccttccat  cttggagta  aagcagagg  1320
agtgtgtgg  aacatggct  tgaccaaag  aagacccca  cttccttag  caggccaca  1380
tatggacca  cctcccata  cccctttat  tttgcaact  taggagcaa  ctacagagg  1440
gctttctag  caagatgta  aagatgatt  tgtgggatg  tgatgggca  agacagggt  1500
gaaatcttc  ccacagagg  ctcagctgc  gaccagact  gcaagttaa  gagtgtcaa  1560
gtccagtcc  tctgacagt  tgtatatct  tctgaaatt  gcactcgag  tgtgctagc  1620
caaaaggga  tcactgctt  tgaaagtaa  atcactgtg  catgggatt  ttttttttt  1680
aaatatggt  atgattatt  aactgaacc  gtgtgttct  gcatacagt  accccaata  1740
gaacttcct  gaaagaagc  aggtttatg  cttgtggaa  aaaacacat  gggctttgg  1800
atacaggaa  gagtttctc  cagtcagtt  tgctttcat  gtctgcagt  ggtaagata  1860
acatttaga  actccgtgc  ttctccaca  tcctccaca  tgtttaaga  gccagggaa  1920
gagtaatat  tttcctatc  tgtcatagc  actcatgaa  ttgtaagaa  ccaagtagg  1980
tccctgaga  aaccaaaga  gtcttggat  atgctgtgt  taaagtttt  ttccagtct  2040
tatggttac  cctaaagag  gaaaactct  aactaatct  agggatata  aaggaacca  2100
aaatctgag  cctgtgcag  tggagaagt  gaagaagac  tggtcttgg  gctctttct  2160
catgctgac  gtagcatgt  cctgaagtt  gtatgcttg  caggtggca  tctagaaat  2220
aggtcattg  tactgtctt  ccgactgtg  ataagtctg  tgttacttt  tcctagctg  2280
gaagccgtt  tcagtctcc  tcagctttc  gtaactctt  ttcagttcc  cacctcttc  2340
attctctct  cctctttag  cctgtttgt  cacctctga  gaaaacctt  ccttctagc  2400
tacgtgcat  ccatcccta  cccgttcca  ttggtgttg  ttctattcc  ttccctctc  2460
ccctgacat  tgcaggttt  ccttggtct  ttttcctcc  gtttctcaa  gttactcag  2520
taacagatc  ccaaataaa  cagcccatt  tcacagctt  taacacttg  taatgatgg  2580
tgctggggt  tgtgcatgt  gacattcta  gtgtctctt  caaactgtc  tttgcctta  2640
cttatggcg  tgggggagg  tgcccaggt  tctcttgct  tgactgtcg  atccattat  2700
tatcctttc  gtgacctca  atttctttg  tctccttcc  aagaacccag  2750



<210> 9544
<211> 357
<212> PRT
<213> Rattus norvegicus
<308> P19814
<400> 9544

Met Gln Phe Leu Val Ala Leu Leu Leu Leu Ser Val Ala Val Ala Arg 
  1               5                  10                  15
Ala Leu Pro Ser Ala Ser Lys Pro Asn Asn Thr Ser Ser Glu Asn Asn 
             20                  25                  30
Pro Pro Ile Gln Pro Ser Thr Pro Leu Pro Pro Gly Val Asp Ile Ser 
         35                  40                  45
Gln Gln Val Lys Thr Asn Arg Pro Thr Asp Gln Arg Leu Glu Ser Asp 
     50                  55                  60
Lys Glu Gly Gln Asp Lys Thr Val Ala Arg Thr Ser Ala Ser Val Ser 
 65                  70                  75                  80
Ser Gly Val Glu Ser Ala Thr Asn Leu Asn Leu Asp Asp Ser Lys Lys 
                 85                  90                  95
His Pro Glu Thr Ala Asp Ala Lys Leu Lys Glu Thr Leu Gln Gln Leu 
             100                105                110
Leu Pro Val Asp Pro Lys Gln Glu Lys Ser Gly Gln Lys Phe Thr Lys 
         115                120                125
Asp Ser Gly Ser Pro Thr Gly Gly Asp Ser Asp Asn Thr Thr Gly Gly 
     130                135                140
Asp Ser Asn Lys Thr Thr Gly Val Asp Ser Asp Lys Thr Ser Gly Gly 
 145                150                155                160
Asp Ser Asn Lys Pro Thr Gly Ser Asp Asn Asp Lys Pro Thr Gly Gly 
                 165                170                175
Asp Ser Asn Lys Pro Thr Ser Lys Val Pro Ser Asn Thr Glu Thr Pro 
             180                185                190
Lys Ile Asp Lys Val Gln Leu Thr Glu Lys Gly Gln Lys Pro Thr Leu 
         195                200                205
Ile Ser Lys Thr Glu Ser Gly Glu Lys Leu Ala Gly Asp Ser Asp Phe 
     210                215                220
Ser Leu Lys Pro Glu Lys Gly Asp Lys Ser Ser Glu Pro Thr Glu Asp 
 225                230                235                240
Val Glu Thr Lys Glu Ile Glu Glu Gly Asp Thr Glu Pro Glu Glu Gly 
                 245                250                255
Ser Pro Leu Glu Glu Glu Asn Glu Lys Val Leu Gly Pro Ser Ser Ser 
             260                265                270
Glu Asn Gln Glu Gly Thr Leu Thr Asp Ser Met Lys Asp Glu Lys Asp 
         275                280                285
Asp His Tyr Lys Asp Asn Ser Gly Asn Thr Ser Ala Glu Ser Ser His 
     290                295                300
Phe Phe Ala Tyr Leu Val Thr Ala Ala Val Leu Val Ala Val Leu Tyr 
 305                310                315                320
Ile Ala Tyr His Asn Lys Arg Lys Ile Ile Ala Phe Ala Leu Glu Gly 
                 325                330                335
Lys Arg Ser Lys Val Thr Arg Arg Pro Lys Ala Ser Asp Tyr Gln Arg 
             340                345                350
Leu Asn Leu Lys Leu 
         355



<210> 9545
<211> 1494
<212> DNA
<213> Homo sapiens
<308> BC008461
<400> 9545

agagggcgg  agcgctatc  gagcaggat  cggttcgta  ttgccttgg  cctcctgaa  60
gtcgcagcg  cgggagccg  gccgctctt  gccaccgaa  gcgtcaagc  agaagatgc  120
ggagtacgg  cttctgcag  aaacgtctc  acccacccc  gcttgagcc  acggcctgg  180
ggctctacc  agtcgcatc  ggagccgca  actccaaaa  acagcccta  caagtcgag  240
gcggaggcg  agaccccag  agacacccc  aacaagtcg  gtgcggagg  aaagaccca  300
aaagacagc  ccaacaagt  gggtgcgga  gcaaagacc  aaaaaggca  cactagcaa  360
tcgggttcg  aggcgcaga  cacaaaaga  agcactagt  agtcgcatc  ggagctgca  420
actccaaaa  acagcactg  caaatcggg  gcggaggcg  agaccccag  agacagccc  480
aacaggtcg  gtgcggagg  aaagaccca  aaagacagc  ctagcaagt  aggttcgga  540
gcgcagacc  caaaagatg  ccctaataa  tcgggtgcg  acggccaga  cccaaaaga  600
ggctccagc  agtcgggtg  ggaggatca  accccaaaa  acgtcccta  caagtcggg  660
gcggagaag  agactccaa  agacggctc  aacaagtcc  gtgcagagg  gcagggccc  720
atagacggg  ccagcaagt  gggtgcgga  gagcagacc  caaaagaca  ccctaacaa  780
gtggttcca  agcagcctt  ccggaaaga  cattccaag  ccatctcca  cccttctga  840
aacaaggag  tccccaagg  tgacacaaa  cagcttgct  acaaaggga  gctttctcc  900
catgctttc  aaaccgaat  tggggagga  actgacctc  tttctcccc  gcaggagga  960
gttaagtct  cagagccta  tgaggatgt  gagcccaaa  aggctgaag  tgatgatac  1020
ggacccgag  agggctcac  gcccaaaga  gagaaagaa  agatgtccg  ttctgcctc  1080
agtgagaac  gtgaaggga  actttcgga  tccacgggt  gcgagaagg  tgaccttta  1140
ccgaacggt  ctggaaatg  cagcgcgga  agcagccac  tctttgcat  tctggtgac  1200
gcagccatt  ttgtggctg  cctctatat  gctcatcac  acaagcgga  gatcattgc  1260
tttgtcctg  aaggaaaaa  atctaaagt  acccggcgg  caaaggcca  tgactacca  1320
cgtttggac  agaagtcct  acagaatgg  atattcctc  ggaaaaaga  gaacgtcac  1380
aatggattg  gctgctctc  tttcagctt  gattttttt  tccttgaga  ccttgtcct  1440
cctgctgat  tgtttctaa  gcaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaa  1494



<210> 9546
<211> 480
<212> PRT
<213> Homo sapiens
<308> O43493
<400> 9546

Met Arg Phe Val Val Ala Leu Val Leu Leu Asn Val Ala Ala Ala Gly 
  1               5                  10                  15
Ala Val Pro Leu Leu Ala Thr Glu Ser Val Lys Gln Glu Glu Ala Gly 
             20                  25                  30
Val Arg Pro Ser Ala Gly Asn Val Ser Thr His Pro Ser Leu Ser Gln 
         35                  40                  45
Arg Pro Gly Gly Ser Thr Lys Ser His Pro Glu Pro Gln Thr Pro Lys 
     50                  55                  60
Asp Ser Pro Ser Lys Ser Ser Ala Glu Ala Gln Thr Pro Glu Asp Thr 
 65                  70                  75                  80
Pro Asn Lys Ser Gly Gly Glu Ala Lys Thr Leu Lys Asp Ser Ser Asn 
                 85                  90                  95
Lys Ser Gly Ala Glu Ala Gln Thr Pro Lys Gly Ser Thr Ser Lys Ser 
             100                105                110
Gly Ser Glu Ala Gln Thr Thr Lys Asp Ser Thr Ser Lys Ser His Pro 
         115                120                125
Glu Leu Gln Thr Pro Lys Asp Ser Thr Gly Lys Ser Gly Ala Glu Ala 
     130                135                140
Gln Thr Pro Glu Asp Ser Pro Asn Arg Ser Gly Ala Glu Pro Lys Thr 
 145                150                155                160
Gln Lys Asp Ser Pro Ser Lys Ser Gly Ser Glu Ala Gln Thr Thr Lys 
                 165                170                175
Asp Val Pro Asn Lys Ser Gly Ala Asp Gly Gln Thr Pro Lys Asp Gly 
             180                185                190
Ser Ser Lys Ser Gly Ala Glu Asp Gln Thr Pro Lys Asp Val Pro Asn 
         195                200                205
Lys Ser Gly Ala Glu Lys Gln Thr Pro Lys Asp Gly Ser Asn Lys Ser 
     210                215                220
Gly Ala Glu Glu Gln Gly Pro Ile Asp Gly Pro Ser Lys Ser Gly Ala 
 225                230                235                240
Glu Glu Gln Thr Ser Lys Asp Ser Pro Asn Lys Val Val Pro Glu Gln 
                 245                250                255
Pro Ser Arg Lys Asp His Ser Lys Pro Ile Ser Asn Pro Ser Asp Asn 
             260                265                270
Lys Glu Leu Pro Lys Ala Asp Thr Asn Gln Leu Ala Asp Lys Gly Lys 
         275                280                285
Leu Ser Pro His Ala Phe Lys Thr Glu Ser Gly Glu Glu Thr Asp Leu 
     290                295                300
Ile Ser Pro Pro Gln Glu Glu Val Lys Ser Ser Glu Pro Thr Glu Asp 
 305                310                315                320
Val Gly Pro Lys Glu Ala Glu Asp Asp Asp Thr Gly Pro Glu Glu Gly 
                 325                330                335
Ser Pro Pro Lys Glu Glu Lys Glu Lys Met Ser Gly Ser Ala Ser Ser 
             340                345                350
Glu Asn Arg Glu Gly Thr Leu Ser Asp Ser Thr Gly Ser Glu Lys Asp 
         355                360                365
Asp Leu Tyr Pro Asn Gly Ser Gly Asn Gly Ser Ala Glu Ser Ser His 
     370                375                380
Phe Phe Ala Tyr Leu Val Thr Ala Ala Ile Leu Val Ala Val Leu Tyr 
 385                390                395                400
Ile Ala His His Asn Lys Arg Lys Ile Ile Ala Phe Val Leu Glu Gly 
                 405                410                415
Lys Arg Ser Lys Val Thr Arg Arg Pro Lys Ala Ser Asp Tyr Gln Arg 
             420                425                430
Leu Asp Gln Lys Tyr Val Leu Ile Leu Asn Val Phe Pro Ala Pro Pro 
         435                440                445
Lys Arg Ser Phe Leu Pro Gln Val Leu Thr Glu Trp Tyr Ile Pro Leu 
     450                455                460
Glu Lys Asp Glu Arg His Gln Trp Ile Val Leu Leu Ser Phe Gln Leu 
 465                470                475                480



<210> 9547
<211> 6335
<212> DNA
<213> Rattus norvegicus
<308> X53581
<400> 9547

ggatcccgg  ccgcagcag  tctctgctc  cagaacccg  gagaaagag  cctcaccgc  60
tggtcaggt  ggcactcct  aggctgcag  gcggaagag  ccaccaaca  tgcccaccc  120
tgcccacat  cctggccca  gaggaaact  tataaggcc  ctgggttcc  tgggggagg  180
cccaggagc  tcaggaccc  tgcctgaga  accgccgga  cctgaggga  acagaccgg  240
taaacagtt  tctgcaccc  aatcccatg  gagggagag  tgaaccttc  gagaggcag  300
caagccttg  aaaccagaa  agactgctc  ctgtacata  atctcggac  ccagaggaa  360
acaccaaag  ccatctgga  ccctggtgc  ctgaagctc  tggaagggg  ggcacaggt  420
ttcctggtt  ctgccgcca  agagagccc  tgggcagca  cccgcctgg  gaactcaag  480
cacaggccc  caggaacag  tgaagacct  cagagagga  aaactacac  cccgaaagc  540
gaacactct  tccccataa  ggactgaaa  agaggaaaa  aggtctaca  cactcctga  600
acacaggct  ataggacag  ctaaccact  tcagaaata  cagaacaaa  taacactag  660
gataatctg  tggtgagag  caagcgcag  aacccaagc  acagaaacc  agactacat  720
gcatcatcg  agcccaatt  tcccaccaa  acaaacatg  aatatccaa  cacaccaga  780
aagcaagat  tagtttcaa  atcatattt  atcatgatg  tggaggact  caagaaaga  840
gtgaagaac  cccttagag  acaagtaga  gcctacaga  aggaatcgc  aaaatccct  900
aaagaattc  aggaaaaca  aatcaaaca  ttgaaggaa  taaaaatgg  aatagaagc  960
atcaagaaa  aacacatgg  aacaaccct  gatatagaa  accaaagga  gagacaagg  1020
gccgtagat  caagcatca  caacagaat  caagagatg  aagagagaa  ctcaagagc  1080
gaagattcc  tagaaatca  tgactcaac  gtcaaagat  atgtaaagc  gaaaaagct  1140
ctggtccaa  acatacagg  aatccagga  tcaatgaga  gatcaaacc  aaggataat  1200
ggtatagaa  agagtgaag  ctcccagct  aaaggacca  taaatgtct  caacaaaat  1260
atagaagaa  acttcccta  cctaaaaaa  gagataccc  taggcatac  agaagccta  1320
agaactcca  atagattgg  ccagaaaag  aacacctcc  gtcacataa  agtcaaaac  1380
ccaaacgca  aaaataaag  aagaatatt  aaagcagta  gggaaaaag  tcaagtaac  1440
tataaaggc  gacctatca  aatcacacc  gacttctcg  cagaaacta  gaaggccag  1500
agatcctgg  cagatgtca  acagaccct  agagaacac  aatgccagc  caggttact  1560
tatcctgca  aactctcaa  taacataga  ggagaaacc  agatattcc  tgacaaaac  1620
aaatttaca  aatatcttt  tacaaatcc  gcactacaa  ggataataa  tggtaaagc  1680
caacataag  aggcaagct  taccctaga  gaagcaaga  actaatcgt  ttggcaaca  1740
aacaaagcg  atgaaagca  acaaacata  cctcacatc  aaatatgaa  ataacggga  1800
gcaataatc  ctattcctt  atatctctc  acataaatg  ccttaactc  ccaataaaa  1860
gacatagat  aacaaactg  atacgcaac  aggaccctg  attctgctg  ctacaggaa  1920
cacacctca  agacaaaga  agacattac  tcagagtga  aggctggaa  acaattttc  1980
aagcaaatg  tcagaagaa  caagctgga  tagccattc  aatatcaaa  aaaatcaat  2040
tttaactaa  agtcatcaa  aaagataag  aaggacact  catattcat  aaaggaaaa  2100
tccaccaag  tgaactctc  atcctaaat  tctatgccc  aaatacaag  gcacctaca  2160
atgtaaaag  aaccttact  aagctcaaa  cacacattg  acctcacac  ataatagtg  2220
gagatttca  caccccact  tcatcaatg  acagatcat  gaaacagaa  ttaaacaga  2280
atgtagaca  actaagaga  gtcatgagc  aaagggact  aacggatat  tatagaaca  2340
tctatccta  agcaaaagg  tataccttc  tctcagctc  tcatggtac  ttctccaaa  2400
ttgaccata  aattggtca  aaaacgggc  tcaacaggt  cagaaagat  gaaataatc  2460
catgcatgc  atcggacca  cacggccta  aactggtct  caataacaa  caaggaaga  2520
tgcccatat  tacttggaa  ctgaacaat  ctctactca  tgataacct  gtcaaggaa  2580
aaataaaga  agaaattaa  aacttttta  aatttaatg  aaatgaagg  acaacatac  2640
caaacttat  ggacacaat  aaagctgtg  taagaggaa  actcatagc  ctgagtgcc  2700
gcagaaaga  acaggaaag  gcatatgtc  gcagcttga  agcacacct  aaagctcta  2760
aacaaaaag  agcaaatac  cccaggagg  gtagaaggc  ggaaataat  aaactcaga  2820
ctgaaatca  ccaagtaga  acaaaagga  catagaaag  atcaacaga  ccaaaagtt  2880
gttctttga  aaaatcaac  agatagata  acccttagc  agactaatg  gaggacaca  2940
agagtgtgt  caaattaac  aaatcagaa  tgaaaaggg  gacataaca  cagattcag  3000
ggaaattca  aaaatcatc  gatcttact  taaaaacct  tattcaaca  aacttgaaa  3060
tcttcagga  atggacaat  ttctagaca  ataccaggt  ccgaagtta  atcaggaac  3120
gataaacca  ttaaacaac  ccataactc  taaggaaat  gaagcagtc  ttaaaggtc  3180
cccaaccaa  aagagccca  gtccagacg  gtttagtgc  gaattctat  aaaccttca  3240
agaagacct  ataccaata  tatccaaac  attccacaa  attgaaaca  atggatcac  3300
accgaatac  ttctacgaa  ccacaatta  tcttatacc  aaaccacac  aagacacaa  3360
aaagaaaga  aacttcaga  caatttccc  tatgaatat  gacgcaaaa  tactcaaca  3420
aattctggc  aaccgaatc  aagagcaca  caaaacaat  atccaccat  accaagtag  3480
cttcatccc  ggcatgcag  gatggttta  tatacggaa  accatcaac  tgatccatt  3540
tataaacaa  ctgaaagaa  aaaaccaca  gatcatttc  ttagacgct  agaaagcat  3600
tgacaaaat  caacacccc  tcatgataa  agtcctgga  agaattgga  ttcaaggcc  3660
atacctgaa  atagtaaaa  ccatataca  caaaccagt  gctaacatt  aactaaatg  3720
agagaaact  gaagcaatc  cactaaaat  agggactag  caaggctgc  cactctctc  3780
ctacttatt  aatatagtt  ttgaagttc  ggccagagc  atcagacaa  aaaaggagg  3840
caaggggat  cagatcgga  aagaagaag  caaaatatc  ctatttgca  atgatatga  3900
agtatattt  agtgatccc  aacattcca  cagagaact  ctaaagctg  tagacaact  3960
cagcaaagt  gctaggtat  aaattaact  aaataaatc  gttgccttc  tctatacaa  4020
agagaaaca  gccgagaaa  aaattaggg  aacgacacc  ttcataata  acccaaata  4080
tataaagta  ctcggtgtg  ctttaacaa  gcaagtaaa  gatctgtac  ataagaact  4140
caagacact  aagaaggaa  ttgaagaag  cctcagaag  tggaaagat  tcccgtgct  4200
atggattgg  aggattaat  tagtaaaaa  ggccatttt  ccaaaagca  tctacagat  4260
caatgcaat  cccatcaaa  taccaatcc  attcttcaa  gagttagac  gaacaattt  4320
caaattcat  tggaataac  aaaaaccca  gatagctaa  gctatcctc  acaataaaa  4380
gacttcagg  ggaatcact  tccctgaac  caagcagta  tacagagca  tagtgataa  4440
aactgcatg  tattggtac  gagacagac  gatagacca  tggaataga  ttgaagacc  4500
agaaatgaa  ccacacacc  atggtcact  gatttttga  aaaggagcc  aaaccatca  4560
atggaaaaa  gatagcatt  tcagcaaat  gtgctagtt  aactggagg  caacatgta  4620
aagaatgaa  atcgatcca  gcttgtcac  ctgtacaag  ttaagtcca  gtggatcaa  4680
gacctccac  tcaaaccag  cacactcaa  ctaatagaa  aaaaactag  gaagcatct  4740
gaacacatg  gcactggaa  aaatttcct  aacaaaaca  catggctta  gctctaaga  4800
caagaatcg  caaatggga  ctcataaaa  tgcaaagct  ctgtaaggc  aaggacact  4860
tggttagga  aaaacggca  ccaacagat  gggaaaata  ctttaccaa  cctacaaca  4920
atagaggcc  tatatccaa  atatacaaa  aactcaaga  gttagaccg  agggaaaca  4980
ataacccta  taaaaaatg  ggttcagag  taaacaaag  attcacagc  gaggaatgc  5040
aaatggctg  gaaacacct  aagaaatgt  caacatctt  agtcataag  gaaatgcaa  5100
tcaaaacaa  cgtgagatt  cacctcaca  cagtgagaa  ggctatgat  aaaaactca  5160
gggacaaca  atgctggcg  ggatgtgga  aaagaggaa  actcctcca  tgttggtgg  5220
attgcaaac  ggtacaacc  ttctggaaa  cagtctgga  gttcctcag  aaattggac  5280
ttgaactgc  tgaggatcc  gctatacct  tcttgggca  atacccaaa  gatgcccca  5340
catataaaa  agacacgtg  tccactatg  tcattgcag  cttatttat  atagccaga  5400
gctggaaag  acccagatg  ccttcaaca  aggaatgga  acagaaaat  tggtacatc  5460
acacaatgg  atattactc  gctatcaaa  acaacgagt  tatgaaatt  gtaggcaaa  5520
ggttggaac  ggaaaatat  atcctgagt  agctaaccc  atcacagaa  gacatacat  5580
gtatgcact  attgataag  ggctattag  ccaaatgct  gaattaccc  agataccta  5640
aacaaatga  actcaagac  gatgatcaa  atgtgaatg  ttcactcct  ctttaaaag  5700
ggaacaaga  tacccttgg  agggaagag  gaggcaaag  ttaaaacag  gaatgaagg  5760
acacccatt  agagcctgc  ccacatgtg  cccatacat  tacagccac  caattagac  5820
agatggatg  agcaaagaa  tgcagaccg  caggagccg  atgtagatc  ctcctgaga  5880
acacagcca  aatacagca  atacagagg  gaatgccag  agcaaacca  tgaactgag  5940
ataggaccc  cgttgaagg  atcagagaa  gaactggaa  atcttgaag  ggctcgaga  6000
cccatatgt  caacaatgc  aagcaacca  agcttccag  gactaagcc  ctacctaaa  6060
actatacat  gactgaccc  ggactctga  ctcataggt  gcaatgaat  tcctagtaa  6120
agcaccagt  gaaggagaa  ccctgggtc  tgctaagac  gaaccccca  tgaactaga  6180
tggtggggg  agggcggca  tggggggag  gttgggagg  gaacaccat  aggaagggg  6240
ggggggagg  ggatgtttg  ccggatacc  aaagggaat  acatcgaaa  gtatataag  6300
atactcaag  taataaaaa  aaaaaaaaa  aaaga  6335



<210> 9548
<211> 6335
<212> DNA
<213> Rattus norvegicus
<308> X53581
<400> 9548

ggatcccgg  ccgcagcag  tctctgctc  cagaacccg  gagaaagag  cctcaccgc  60
tggtcaggt  ggcactcct  aggctgcag  gcggaagag  ccaccaaca  tgcccaccc  120
tgcccacat  cctggccca  gaggaaact  tataaggcc  ctgggttcc  tgggggagg  180
cccaggagc  tcaggaccc  tgcctgaga  accgccgga  cctgaggga  acagaccgg  240
taaacagtt  tctgcaccc  aatcccatg  gagggagag  tgaaccttc  gagaggcag  300
caagccttg  aaaccagaa  agactgctc  ctgtacata  atctcggac  ccagaggaa  360
acaccaaag  ccatctgga  ccctggtgc  ctgaagctc  tggaagggg  ggcacaggt  420
ttcctggtt  ctgccgcca  agagagccc  tgggcagca  cccgcctgg  gaactcaag  480
cacaggccc  caggaacag  tgaagacct  cagagagga  aaactacac  cccgaaagc  540
gaacactct  tccccataa  ggactgaaa  agaggaaaa  aggtctaca  cactcctga  600
acacaggct  ataggacag  ctaaccact  tcagaaata  cagaacaaa  taacactag  660
gataatctg  tggtgagag  caagcgcag  aacccaagc  acagaaacc  agactacat  720
gcatcatcg  agcccaatt  tcccaccaa  acaaacatg  aatatccaa  cacaccaga  780
aagcaagat  tagtttcaa  atcatattt  atcatgatg  tggaggact  caagaaaga  840
gtgaagaac  cccttagag  acaagtaga  gcctacaga  aggaatcgc  aaaatccct  900
aaagaattc  aggaaaaca  aatcaaaca  ttgaaggaa  taaaaatgg  aatagaagc  960
atcaagaaa  aacacatgg  aacaaccct  gatatagaa  accaaagga  gagacaagg  1020
gccgtagat  caagcatca  caacagaat  caagagatg  aagagagaa  ctcaagagc  1080
gaagattcc  tagaaatca  tgactcaac  gtcaaagat  atgtaaagc  gaaaaagct  1140
ctggtccaa  acatacagg  aatccagga  tcaatgaga  gatcaaacc  aaggataat  1200
ggtatagaa  agagtgaag  ctcccagct  aaaggacca  taaatgtct  caacaaaat  1260
atagaagaa  acttcccta  cctaaaaaa  gagataccc  taggcatac  agaagccta  1320
agaactcca  atagattgg  ccagaaaag  aacacctcc  gtcacataa  agtcaaaac  1380
ccaaacgca  aaaataaag  aagaatatt  aaagcagta  gggaaaaag  tcaagtaac  1440
tataaaggc  gacctatca  aatcacacc  gacttctcg  cagaaacta  gaaggccag  1500
agatcctgg  cagatgtca  acagaccct  agagaacac  aatgccagc  caggttact  1560
tatcctgca  aactctcaa  taacataga  ggagaaacc  agatattcc  tgacaaaac  1620
aaatttaca  aatatcttt  tacaaatcc  gcactacaa  ggataataa  tggtaaagc  1680
caacataag  aggcaagct  taccctaga  gaagcaaga  actaatcgt  ttggcaaca  1740
aacaaagcg  atgaaagca  acaaacata  cctcacatc  aaatatgaa  ataacggga  1800
gcaataatc  ctattcctt  atatctctc  acataaatg  ccttaactc  ccaataaaa  1860
gacatagat  aacaaactg  atacgcaac  aggaccctg  attctgctg  ctacaggaa  1920
cacacctca  agacaaaga  agacattac  tcagagtga  aggctggaa  acaattttc  1980
aagcaaatg  tcagaagaa  caagctgga  tagccattc  aatatcaaa  aaaatcaat  2040
tttaactaa  agtcatcaa  aaagataag  aaggacact  catattcat  aaaggaaaa  2100
tccaccaag  tgaactctc  atcctaaat  tctatgccc  aaatacaag  gcacctaca  2160
atgtaaaag  aaccttact  aagctcaaa  cacacattg  acctcacac  ataatagtg  2220
gagatttca  caccccact  tcatcaatg  acagatcat  gaaacagaa  ttaaacaga  2280
atgtagaca  actaagaga  gtcatgagc  aaagggact  aacggatat  tatagaaca  2340
tctatccta  agcaaaagg  tataccttc  tctcagctc  tcatggtac  ttctccaaa  2400
ttgaccata  aattggtca  aaaacgggc  tcaacaggt  cagaaagat  gaaataatc  2460
catgcatgc  atcggacca  cacggccta  aactggtct  caataacaa  caaggaaga  2520
tgcccatat  tacttggaa  ctgaacaat  ctctactca  tgataacct  gtcaaggaa  2580
aaataaaga  agaaattaa  aacttttta  aatttaatg  aaatgaagg  acaacatac  2640
caaacttat  ggacacaat  aaagctgtg  taagaggaa  actcatagc  ctgagtgcc  2700
gcagaaaga  acaggaaag  gcatatgtc  gcagcttga  agcacacct  aaagctcta  2760
aacaaaaag  agcaaatac  cccaggagg  gtagaaggc  ggaaataat  aaactcaga  2820
ctgaaatca  ccaagtaga  acaaaagga  catagaaag  atcaacaga  ccaaaagtt  2880
gttctttga  aaaatcaac  agatagata  acccttagc  agactaatg  gaggacaca  2940
agagtgtgt  caaattaac  aaatcagaa  tgaaaaggg  gacataaca  cagattcag  3000
ggaaattca  aaaatcatc  gatcttact  taaaaacct  tattcaaca  aacttgaaa  3060
tcttcagga  atggacaat  ttctagaca  ataccaggt  ccgaagtta  atcaggaac  3120
gataaacca  ttaaacaac  ccataactc  taaggaaat  gaagcagtc  ttaaaggtc  3180
cccaaccaa  aagagccca  gtccagacg  gtttagtgc  gaattctat  aaaccttca  3240
agaagacct  ataccaata  tatccaaac  attccacaa  attgaaaca  atggatcac  3300
accgaatac  ttctacgaa  ccacaatta  tcttatacc  aaaccacac  aagacacaa  3360
aaagaaaga  aacttcaga  caatttccc  tatgaatat  gacgcaaaa  tactcaaca  3420
aattctggc  aaccgaatc  aagagcaca  caaaacaat  atccaccat  accaagtag  3480
cttcatccc  ggcatgcag  gatggttta  tatacggaa  accatcaac  tgatccatt  3540
tataaacaa  ctgaaagaa  aaaaccaca  gatcatttc  ttagacgct  agaaagcat  3600
tgacaaaat  caacacccc  tcatgataa  agtcctgga  agaattgga  ttcaaggcc  3660
atacctgaa  atagtaaaa  ccatataca  caaaccagt  gctaacatt  aactaaatg  3720
agagaaact  gaagcaatc  cactaaaat  agggactag  caaggctgc  cactctctc  3780
ctacttatt  aatatagtt  ttgaagttc  ggccagagc  atcagacaa  aaaaggagg  3840
caaggggat  cagatcgga  aagaagaag  caaaatatc  ctatttgca  atgatatga  3900
agtatattt  agtgatccc  aacattcca  cagagaact  ctaaagctg  tagacaact  3960
cagcaaagt  gctaggtat  aaattaact  aaataaatc  gttgccttc  tctatacaa  4020
agagaaaca  gccgagaaa  aaattaggg  aacgacacc  ttcataata  acccaaata  4080
tataaagta  ctcggtgtg  ctttaacaa  gcaagtaaa  gatctgtac  ataagaact  4140
caagacact  aagaaggaa  ttgaagaag  cctcagaag  tggaaagat  tcccgtgct  4200
atggattgg  aggattaat  tagtaaaaa  ggccatttt  ccaaaagca  tctacagat  4260
caatgcaat  cccatcaaa  taccaatcc  attcttcaa  gagttagac  gaacaattt  4320
caaattcat  tggaataac  aaaaaccca  gatagctaa  gctatcctc  acaataaaa  4380
gacttcagg  ggaatcact  tccctgaac  caagcagta  tacagagca  tagtgataa  4440
aactgcatg  tattggtac  gagacagac  gatagacca  tggaataga  ttgaagacc  4500
agaaatgaa  ccacacacc  atggtcact  gatttttga  aaaggagcc  aaaccatca  4560
atggaaaaa  gatagcatt  tcagcaaat  gtgctagtt  aactggagg  caacatgta  4620
aagaatgaa  atcgatcca  gcttgtcac  ctgtacaag  ttaagtcca  gtggatcaa  4680
gacctccac  tcaaaccag  cacactcaa  ctaatagaa  aaaaactag  gaagcatct  4740
gaacacatg  gcactggaa  aaatttcct  aacaaaaca  catggctta  gctctaaga  4800
caagaatcg  caaatggga  ctcataaaa  tgcaaagct  ctgtaaggc  aaggacact  4860
tggttagga  aaaacggca  ccaacagat  gggaaaata  ctttaccaa  cctacaaca  4920
atagaggcc  tatatccaa  atatacaaa  aactcaaga  gttagaccg  agggaaaca  4980
ataacccta  taaaaaatg  ggttcagag  taaacaaag  attcacagc  gaggaatgc  5040
aaatggctg  gaaacacct  aagaaatgt  caacatctt  agtcataag  gaaatgcaa  5100
tcaaaacaa  cgtgagatt  cacctcaca  cagtgagaa  ggctatgat  aaaaactca  5160
gggacaaca  atgctggcg  ggatgtgga  aaagaggaa  actcctcca  tgttggtgg  5220
attgcaaac  ggtacaacc  ttctggaaa  cagtctgga  gttcctcag  aaattggac  5280
ttgaactgc  tgaggatcc  gctatacct  tcttgggca  atacccaaa  gatgcccca  5340
catataaaa  agacacgtg  tccactatg  tcattgcag  cttatttat  atagccaga  5400
gctggaaag  acccagatg  ccttcaaca  aggaatgga  acagaaaat  tggtacatc  5460
acacaatgg  atattactc  gctatcaaa  acaacgagt  tatgaaatt  gtaggcaaa  5520
ggttggaac  ggaaaatat  atcctgagt  agctaaccc  atcacagaa  gacatacat  5580
gtatgcact  attgataag  ggctattag  ccaaatgct  gaattaccc  agataccta  5640
aacaaatga  actcaagac  gatgatcaa  atgtgaatg  ttcactcct  ctttaaaag  5700
ggaacaaga  tacccttgg  agggaagag  gaggcaaag  ttaaaacag  gaatgaagg  5760
acacccatt  agagcctgc  ccacatgtg  cccatacat  tacagccac  caattagac  5820
agatggatg  agcaaagaa  tgcagaccg  caggagccg  atgtagatc  ctcctgaga  5880
acacagcca  aatacagca  atacagagg  gaatgccag  agcaaacca  tgaactgag  5940
ataggaccc  cgttgaagg  atcagagaa  gaactggaa  atcttgaag  ggctcgaga  6000
cccatatgt  caacaatgc  aagcaacca  agcttccag  gactaagcc  ctacctaaa  6060
actatacat  gactgaccc  ggactctga  ctcataggt  gcaatgaat  tcctagtaa  6120
agcaccagt  gaaggagaa  ccctgggtc  tgctaagac  gaaccccca  tgaactaga  6180
tggtggggg  agggcggca  tggggggag  gttgggagg  gaacaccat  aggaagggg  6240
ggggggagg  ggatgtttg  ccggatacc  aaagggaat  acatcgaaa  gtatataag  6300
atactcaag  taataaaaa  aaaaaaaaa  aaaga  6335



<210> 9549
<211> 6335
<212> DNA
<213> Rattus norvegicus
<308> X53581
<400> 9549

ggatcccgg  ccgcagcag  tctctgctc  cagaacccg  gagaaagag  cctcaccgc  60
tggtcaggt  ggcactcct  aggctgcag  gcggaagag  ccaccaaca  tgcccaccc  120
tgcccacat  cctggccca  gaggaaact  tataaggcc  ctgggttcc  tgggggagg  180
cccaggagc  tcaggaccc  tgcctgaga  accgccgga  cctgaggga  acagaccgg  240
taaacagtt  tctgcaccc  aatcccatg  gagggagag  tgaaccttc  gagaggcag  300
caagccttg  aaaccagaa  agactgctc  ctgtacata  atctcggac  ccagaggaa  360
acaccaaag  ccatctgga  ccctggtgc  ctgaagctc  tggaagggg  ggcacaggt  420
ttcctggtt  ctgccgcca  agagagccc  tgggcagca  cccgcctgg  gaactcaag  480
cacaggccc  caggaacag  tgaagacct  cagagagga  aaactacac  cccgaaagc  540
gaacactct  tccccataa  ggactgaaa  agaggaaaa  aggtctaca  cactcctga  600
acacaggct  ataggacag  ctaaccact  tcagaaata  cagaacaaa  taacactag  660
gataatctg  tggtgagag  caagcgcag  aacccaagc  acagaaacc  agactacat  720
gcatcatcg  agcccaatt  tcccaccaa  acaaacatg  aatatccaa  cacaccaga  780
aagcaagat  tagtttcaa  atcatattt  atcatgatg  tggaggact  caagaaaga  840
gtgaagaac  cccttagag  acaagtaga  gcctacaga  aggaatcgc  aaaatccct  900
aaagaattc  aggaaaaca  aatcaaaca  ttgaaggaa  taaaaatgg  aatagaagc  960
atcaagaaa  aacacatgg  aacaaccct  gatatagaa  accaaagga  gagacaagg  1020
gccgtagat  caagcatca  caacagaat  caagagatg  aagagagaa  ctcaagagc  1080
gaagattcc  tagaaatca  tgactcaac  gtcaaagat  atgtaaagc  gaaaaagct  1140
ctggtccaa  acatacagg  aatccagga  tcaatgaga  gatcaaacc  aaggataat  1200
ggtatagaa  agagtgaag  ctcccagct  aaaggacca  taaatgtct  caacaaaat  1260
atagaagaa  acttcccta  cctaaaaaa  gagataccc  taggcatac  agaagccta  1320
agaactcca  atagattgg  ccagaaaag  aacacctcc  gtcacataa  agtcaaaac  1380
ccaaacgca  aaaataaag  aagaatatt  aaagcagta  gggaaaaag  tcaagtaac  1440
tataaaggc  gacctatca  aatcacacc  gacttctcg  cagaaacta  gaaggccag  1500
agatcctgg  cagatgtca  acagaccct  agagaacac  aatgccagc  caggttact  1560
tatcctgca  aactctcaa  taacataga  ggagaaacc  agatattcc  tgacaaaac  1620
aaatttaca  aatatcttt  tacaaatcc  gcactacaa  ggataataa  tggtaaagc  1680
caacataag  aggcaagct  taccctaga  gaagcaaga  actaatcgt  ttggcaaca  1740
aacaaagcg  atgaaagca  acaaacata  cctcacatc  aaatatgaa  ataacggga  1800
gcaataatc  ctattcctt  atatctctc  acataaatg  ccttaactc  ccaataaaa  1860
gacatagat  aacaaactg  atacgcaac  aggaccctg  attctgctg  ctacaggaa  1920
cacacctca  agacaaaga  agacattac  tcagagtga  aggctggaa  acaattttc  1980
aagcaaatg  tcagaagaa  caagctgga  tagccattc  aatatcaaa  aaaatcaat  2040
tttaactaa  agtcatcaa  aaagataag  aaggacact  catattcat  aaaggaaaa  2100
tccaccaag  tgaactctc  atcctaaat  tctatgccc  aaatacaag  gcacctaca  2160
atgtaaaag  aaccttact  aagctcaaa  cacacattg  acctcacac  ataatagtg  2220
gagatttca  caccccact  tcatcaatg  acagatcat  gaaacagaa  ttaaacaga  2280
atgtagaca  actaagaga  gtcatgagc  aaagggact  aacggatat  tatagaaca  2340
tctatccta  agcaaaagg  tataccttc  tctcagctc  tcatggtac  ttctccaaa  2400
ttgaccata  aattggtca  aaaacgggc  tcaacaggt  cagaaagat  gaaataatc  2460
catgcatgc  atcggacca  cacggccta  aactggtct  caataacaa  caaggaaga  2520
tgcccatat  tacttggaa  ctgaacaat  ctctactca  tgataacct  gtcaaggaa  2580
aaataaaga  agaaattaa  aacttttta  aatttaatg  aaatgaagg  acaacatac  2640
caaacttat  ggacacaat  aaagctgtg  taagaggaa  actcatagc  ctgagtgcc  2700
gcagaaaga  acaggaaag  gcatatgtc  gcagcttga  agcacacct  aaagctcta  2760
aacaaaaag  agcaaatac  cccaggagg  gtagaaggc  ggaaataat  aaactcaga  2820
ctgaaatca  ccaagtaga  acaaaagga  catagaaag  atcaacaga  ccaaaagtt  2880
gttctttga  aaaatcaac  agatagata  acccttagc  agactaatg  gaggacaca  2940
agagtgtgt  caaattaac  aaatcagaa  tgaaaaggg  gacataaca  cagattcag  3000
ggaaattca  aaaatcatc  gatcttact  taaaaacct  tattcaaca  aacttgaaa  3060
tcttcagga  atggacaat  ttctagaca  ataccaggt  ccgaagtta  atcaggaac  3120
gataaacca  ttaaacaac  ccataactc  taaggaaat  gaagcagtc  ttaaaggtc  3180
cccaaccaa  aagagccca  gtccagacg  gtttagtgc  gaattctat  aaaccttca  3240
agaagacct  ataccaata  tatccaaac  attccacaa  attgaaaca  atggatcac  3300
accgaatac  ttctacgaa  ccacaatta  tcttatacc  aaaccacac  aagacacaa  3360
aaagaaaga  aacttcaga  caatttccc  tatgaatat  gacgcaaaa  tactcaaca  3420
aattctggc  aaccgaatc  aagagcaca  caaaacaat  atccaccat  accaagtag  3480
cttcatccc  ggcatgcag  gatggttta  tatacggaa  accatcaac  tgatccatt  3540
tataaacaa  ctgaaagaa  aaaaccaca  gatcatttc  ttagacgct  agaaagcat  3600
tgacaaaat  caacacccc  tcatgataa  agtcctgga  agaattgga  ttcaaggcc  3660
atacctgaa  atagtaaaa  ccatataca  caaaccagt  gctaacatt  aactaaatg  3720
agagaaact  gaagcaatc  cactaaaat  agggactag  caaggctgc  cactctctc  3780
ctacttatt  aatatagtt  ttgaagttc  ggccagagc  atcagacaa  aaaaggagg  3840
caaggggat  cagatcgga  aagaagaag  caaaatatc  ctatttgca  atgatatga  3900
agtatattt  agtgatccc  aacattcca  cagagaact  ctaaagctg  tagacaact  3960
cagcaaagt  gctaggtat  aaattaact  aaataaatc  gttgccttc  tctatacaa  4020
agagaaaca  gccgagaaa  aaattaggg  aacgacacc  ttcataata  acccaaata  4080
tataaagta  ctcggtgtg  ctttaacaa  gcaagtaaa  gatctgtac  ataagaact  4140
caagacact  aagaaggaa  ttgaagaag  cctcagaag  tggaaagat  tcccgtgct  4200
atggattgg  aggattaat  tagtaaaaa  ggccatttt  ccaaaagca  tctacagat  4260
caatgcaat  cccatcaaa  taccaatcc  attcttcaa  gagttagac  gaacaattt  4320
caaattcat  tggaataac  aaaaaccca  gatagctaa  gctatcctc  acaataaaa  4380
gacttcagg  ggaatcact  tccctgaac  caagcagta  tacagagca  tagtgataa  4440
aactgcatg  tattggtac  gagacagac  gatagacca  tggaataga  ttgaagacc  4500
agaaatgaa  ccacacacc  atggtcact  gatttttga  aaaggagcc  aaaccatca  4560
atggaaaaa  gatagcatt  tcagcaaat  gtgctagtt  aactggagg  caacatgta  4620
aagaatgaa  atcgatcca  gcttgtcac  ctgtacaag  ttaagtcca  gtggatcaa  4680
gacctccac  tcaaaccag  cacactcaa  ctaatagaa  aaaaactag  gaagcatct  4740
gaacacatg  gcactggaa  aaatttcct  aacaaaaca  catggctta  gctctaaga  4800
caagaatcg  caaatggga  ctcataaaa  tgcaaagct  ctgtaaggc  aaggacact  4860
tggttagga  aaaacggca  ccaacagat  gggaaaata  ctttaccaa  cctacaaca  4920
atagaggcc  tatatccaa  atatacaaa  aactcaaga  gttagaccg  agggaaaca  4980
ataacccta  taaaaaatg  ggttcagag  taaacaaag  attcacagc  gaggaatgc  5040
aaatggctg  gaaacacct  aagaaatgt  caacatctt  agtcataag  gaaatgcaa  5100
tcaaaacaa  cgtgagatt  cacctcaca  cagtgagaa  ggctatgat  aaaaactca  5160
gggacaaca  atgctggcg  ggatgtgga  aaagaggaa  actcctcca  tgttggtgg  5220
attgcaaac  ggtacaacc  ttctggaaa  cagtctgga  gttcctcag  aaattggac  5280
ttgaactgc  tgaggatcc  gctatacct  tcttgggca  atacccaaa  gatgcccca  5340
catataaaa  agacacgtg  tccactatg  tcattgcag  cttatttat  atagccaga  5400
gctggaaag  acccagatg  ccttcaaca  aggaatgga  acagaaaat  tggtacatc  5460
acacaatgg  atattactc  gctatcaaa  acaacgagt  tatgaaatt  gtaggcaaa  5520
ggttggaac  ggaaaatat  atcctgagt  agctaaccc  atcacagaa  gacatacat  5580
gtatgcact  attgataag  ggctattag  ccaaatgct  gaattaccc  agataccta  5640
aacaaatga  actcaagac  gatgatcaa  atgtgaatg  ttcactcct  ctttaaaag  5700
ggaacaaga  tacccttgg  agggaagag  gaggcaaag  ttaaaacag  gaatgaagg  5760
acacccatt  agagcctgc  ccacatgtg  cccatacat  tacagccac  caattagac  5820
agatggatg  agcaaagaa  tgcagaccg  caggagccg  atgtagatc  ctcctgaga  5880
acacagcca  aatacagca  atacagagg  gaatgccag  agcaaacca  tgaactgag  5940
ataggaccc  cgttgaagg  atcagagaa  gaactggaa  atcttgaag  ggctcgaga  6000
cccatatgt  caacaatgc  aagcaacca  agcttccag  gactaagcc  ctacctaaa  6060
actatacat  gactgaccc  ggactctga  ctcataggt  gcaatgaat  tcctagtaa  6120
agcaccagt  gaaggagaa  ccctgggtc  tgctaagac  gaaccccca  tgaactaga  6180
tggtggggg  agggcggca  tggggggag  gttgggagg  gaacaccat  aggaagggg  6240
ggggggagg  ggatgtttg  ccggatacc  aaagggaat  acatcgaaa  gtatataag  6300
atactcaag  taataaaaa  aaaaaaaaa  aaaga  6335



<210> 9550
<211> 6335
<212> DNA
<213> Rattus norvegicus
<308> X53581
<400> 9550

ggatcccgg  ccgcagcag  tctctgctc  cagaacccg  gagaaagag  cctcaccgc  60
tggtcaggt  ggcactcct  aggctgcag  gcggaagag  ccaccaaca  tgcccaccc  120
tgcccacat  cctggccca  gaggaaact  tataaggcc  ctgggttcc  tgggggagg  180
cccaggagc  tcaggaccc  tgcctgaga  accgccgga  cctgaggga  acagaccgg  240
taaacagtt  tctgcaccc  aatcccatg  gagggagag  tgaaccttc  gagaggcag  300
caagccttg  aaaccagaa  agactgctc  ctgtacata  atctcggac  ccagaggaa  360
acaccaaag  ccatctgga  ccctggtgc  ctgaagctc  tggaagggg  ggcacaggt  420
ttcctggtt  ctgccgcca  agagagccc  tgggcagca  cccgcctgg  gaactcaag  480
cacaggccc  caggaacag  tgaagacct  cagagagga  aaactacac  cccgaaagc  540
gaacactct  tccccataa  ggactgaaa  agaggaaaa  aggtctaca  cactcctga  600
acacaggct  ataggacag  ctaaccact  tcagaaata  cagaacaaa  taacactag  660
gataatctg  tggtgagag  caagcgcag  aacccaagc  acagaaacc  agactacat  720
gcatcatcg  agcccaatt  tcccaccaa  acaaacatg  aatatccaa  cacaccaga  780
aagcaagat  tagtttcaa  atcatattt  atcatgatg  tggaggact  caagaaaga  840
gtgaagaac  cccttagag  acaagtaga  gcctacaga  aggaatcgc  aaaatccct  900
aaagaattc  aggaaaaca  aatcaaaca  ttgaaggaa  taaaaatgg  aatagaagc  960
atcaagaaa  aacacatgg  aacaaccct  gatatagaa  accaaagga  gagacaagg  1020
gccgtagat  caagcatca  caacagaat  caagagatg  aagagagaa  ctcaagagc  1080
gaagattcc  tagaaatca  tgactcaac  gtcaaagat  atgtaaagc  gaaaaagct  1140
ctggtccaa  acatacagg  aatccagga  tcaatgaga  gatcaaacc  aaggataat  1200
ggtatagaa  agagtgaag  ctcccagct  aaaggacca  taaatgtct  caacaaaat  1260
atagaagaa  acttcccta  cctaaaaaa  gagataccc  taggcatac  agaagccta  1320
agaactcca  atagattgg  ccagaaaag  aacacctcc  gtcacataa  agtcaaaac  1380
ccaaacgca  aaaataaag  aagaatatt  aaagcagta  gggaaaaag  tcaagtaac  1440
tataaaggc  gacctatca  aatcacacc  gacttctcg  cagaaacta  gaaggccag  1500
agatcctgg  cagatgtca  acagaccct  agagaacac  aatgccagc  caggttact  1560
tatcctgca  aactctcaa  taacataga  ggagaaacc  agatattcc  tgacaaaac  1620
aaatttaca  aatatcttt  tacaaatcc  gcactacaa  ggataataa  tggtaaagc  1680
caacataag  aggcaagct  taccctaga  gaagcaaga  actaatcgt  ttggcaaca  1740
aacaaagcg  atgaaagca  acaaacata  cctcacatc  aaatatgaa  ataacggga  1800
gcaataatc  ctattcctt  atatctctc  acataaatg  ccttaactc  ccaataaaa  1860
gacatagat  aacaaactg  atacgcaac  aggaccctg  attctgctg  ctacaggaa  1920
cacacctca  agacaaaga  agacattac  tcagagtga  aggctggaa  acaattttc  1980
aagcaaatg  tcagaagaa  caagctgga  tagccattc  aatatcaaa  aaaatcaat  2040
tttaactaa  agtcatcaa  aaagataag  aaggacact  catattcat  aaaggaaaa  2100
tccaccaag  tgaactctc  atcctaaat  tctatgccc  aaatacaag  gcacctaca  2160
atgtaaaag  aaccttact  aagctcaaa  cacacattg  acctcacac  ataatagtg  2220
gagatttca  caccccact  tcatcaatg  acagatcat  gaaacagaa  ttaaacaga  2280
atgtagaca  actaagaga  gtcatgagc  aaagggact  aacggatat  tatagaaca  2340
tctatccta  agcaaaagg  tataccttc  tctcagctc  tcatggtac  ttctccaaa  2400
ttgaccata  aattggtca  aaaacgggc  tcaacaggt  cagaaagat  gaaataatc  2460
catgcatgc  atcggacca  cacggccta  aactggtct  caataacaa  caaggaaga  2520
tgcccatat  tacttggaa  ctgaacaat  ctctactca  tgataacct  gtcaaggaa  2580
aaataaaga  agaaattaa  aacttttta  aatttaatg  aaatgaagg  acaacatac  2640
caaacttat  ggacacaat  aaagctgtg  taagaggaa  actcatagc  ctgagtgcc  2700
gcagaaaga  acaggaaag  gcatatgtc  gcagcttga  agcacacct  aaagctcta  2760
aacaaaaag  agcaaatac  cccaggagg  gtagaaggc  ggaaataat  aaactcaga  2820
ctgaaatca  ccaagtaga  acaaaagga  catagaaag  atcaacaga  ccaaaagtt  2880
gttctttga  aaaatcaac  agatagata  acccttagc  agactaatg  gaggacaca  2940
agagtgtgt  caaattaac  aaatcagaa  tgaaaaggg  gacataaca  cagattcag  3000
ggaaattca  aaaatcatc  gatcttact  taaaaacct  tattcaaca  aacttgaaa  3060
tcttcagga  atggacaat  ttctagaca  ataccaggt  ccgaagtta  atcaggaac  3120
gataaacca  ttaaacaac  ccataactc  taaggaaat  gaagcagtc  ttaaaggtc  3180
cccaaccaa  aagagccca  gtccagacg  gtttagtgc  gaattctat  aaaccttca  3240
agaagacct  ataccaata  tatccaaac  attccacaa  attgaaaca  atggatcac  3300
accgaatac  ttctacgaa  ccacaatta  tcttatacc  aaaccacac  aagacacaa  3360
aaagaaaga  aacttcaga  caatttccc  tatgaatat  gacgcaaaa  tactcaaca  3420
aattctggc  aaccgaatc  aagagcaca  caaaacaat  atccaccat  accaagtag  3480
cttcatccc  ggcatgcag  gatggttta  tatacggaa  accatcaac  tgatccatt  3540
tataaacaa  ctgaaagaa  aaaaccaca  gatcatttc  ttagacgct  agaaagcat  3600
tgacaaaat  caacacccc  tcatgataa  agtcctgga  agaattgga  ttcaaggcc  3660
atacctgaa  atagtaaaa  ccatataca  caaaccagt  gctaacatt  aactaaatg  3720
agagaaact  gaagcaatc  cactaaaat  agggactag  caaggctgc  cactctctc  3780
ctacttatt  aatatagtt  ttgaagttc  ggccagagc  atcagacaa  aaaaggagg  3840
caaggggat  cagatcgga  aagaagaag  caaaatatc  ctatttgca  atgatatga  3900
agtatattt  agtgatccc  aacattcca  cagagaact  ctaaagctg  tagacaact  3960
cagcaaagt  gctaggtat  aaattaact  aaataaatc  gttgccttc  tctatacaa  4020
agagaaaca  gccgagaaa  aaattaggg  aacgacacc  ttcataata  acccaaata  4080
tataaagta  ctcggtgtg  ctttaacaa  gcaagtaaa  gatctgtac  ataagaact  4140
caagacact  aagaaggaa  ttgaagaag  cctcagaag  tggaaagat  tcccgtgct  4200
atggattgg  aggattaat  tagtaaaaa  ggccatttt  ccaaaagca  tctacagat  4260
caatgcaat  cccatcaaa  taccaatcc  attcttcaa  gagttagac  gaacaattt  4320
caaattcat  tggaataac  aaaaaccca  gatagctaa  gctatcctc  acaataaaa  4380
gacttcagg  ggaatcact  tccctgaac  caagcagta  tacagagca  tagtgataa  4440
aactgcatg  tattggtac  gagacagac  gatagacca  tggaataga  ttgaagacc  4500
agaaatgaa  ccacacacc  atggtcact  gatttttga  aaaggagcc  aaaccatca  4560
atggaaaaa  gatagcatt  tcagcaaat  gtgctagtt  aactggagg  caacatgta  4620
aagaatgaa  atcgatcca  gcttgtcac  ctgtacaag  ttaagtcca  gtggatcaa  4680
gacctccac  tcaaaccag  cacactcaa  ctaatagaa  aaaaactag  gaagcatct  4740
gaacacatg  gcactggaa  aaatttcct  aacaaaaca  catggctta  gctctaaga  4800
caagaatcg  caaatggga  ctcataaaa  tgcaaagct  ctgtaaggc  aaggacact  4860
tggttagga  aaaacggca  ccaacagat  gggaaaata  ctttaccaa  cctacaaca  4920
atagaggcc  tatatccaa  atatacaaa  aactcaaga  gttagaccg  agggaaaca  4980
ataacccta  taaaaaatg  ggttcagag  taaacaaag  attcacagc  gaggaatgc  5040
aaatggctg  gaaacacct  aagaaatgt  caacatctt  agtcataag  gaaatgcaa  5100
tcaaaacaa  cgtgagatt  cacctcaca  cagtgagaa  ggctatgat  aaaaactca  5160
gggacaaca  atgctggcg  ggatgtgga  aaagaggaa  actcctcca  tgttggtgg  5220
attgcaaac  ggtacaacc  ttctggaaa  cagtctgga  gttcctcag  aaattggac  5280
ttgaactgc  tgaggatcc  gctatacct  tcttgggca  atacccaaa  gatgcccca  5340
catataaaa  agacacgtg  tccactatg  tcattgcag  cttatttat  atagccaga  5400
gctggaaag  acccagatg  ccttcaaca  aggaatgga  acagaaaat  tggtacatc  5460
acacaatgg  atattactc  gctatcaaa  acaacgagt  tatgaaatt  gtaggcaaa  5520
ggttggaac  ggaaaatat  atcctgagt  agctaaccc  atcacagaa  gacatacat  5580
gtatgcact  attgataag  ggctattag  ccaaatgct  gaattaccc  agataccta  5640
aacaaatga  actcaagac  gatgatcaa  atgtgaatg  ttcactcct  ctttaaaag  5700
ggaacaaga  tacccttgg  agggaagag  gaggcaaag  ttaaaacag  gaatgaagg  5760
acacccatt  agagcctgc  ccacatgtg  cccatacat  tacagccac  caattagac  5820
agatggatg  agcaaagaa  tgcagaccg  caggagccg  atgtagatc  ctcctgaga  5880
acacagcca  aatacagca  atacagagg  gaatgccag  agcaaacca  tgaactgag  5940
ataggaccc  cgttgaagg  atcagagaa  gaactggaa  atcttgaag  ggctcgaga  6000
cccatatgt  caacaatgc  aagcaacca  agcttccag  gactaagcc  ctacctaaa  6060
actatacat  gactgaccc  ggactctga  ctcataggt  gcaatgaat  tcctagtaa  6120
agcaccagt  gaaggagaa  ccctgggtc  tgctaagac  gaaccccca  tgaactaga  6180
tggtggggg  agggcggca  tggggggag  gttgggagg  gaacaccat  aggaagggg  6240
ggggggagg  ggatgtttg  ccggatacc  aaagggaat  acatcgaaa  gtatataag  6300
atactcaag  taataaaaa  aaaaaaaaa  aaaga  6335



<210> 9551
<211> 3109
<212> DNA
<213> Rattus norvegicus
<308> X53773
<400> 9551

tccagcccg  cgccgagcc  ctcccgggt  gcaaagatg  cggccgtat  caaggggga  60
gggatgcga  gcctagcgg  cttcatctc  gatatccgt  actgtaaaa  taaagaagc  120
gaaataaag  ggataaata  ggagctggc  aatattaga  caaaattta  aggtgacaa  180
gctcttgat  gctacagta  gaagaagta  gtctgcaag  tactcttca  ctttctcct  240
ggtcatgac  ttgacttcg  acacatgga  gctgtgaat  ttctgagct  aaacagata  300
acggaaaag  agatcggct  ccttttcat  tctgtattg  tgaattcaa  tagtgaact  360
atccggttg  ttaacaatg  catcaagaa  gacctggcc  gccgcaatc  tacatttat  420
ggtctggcc  tgcactgca  cgccaatgt  ggtagccgt  agatggcag  ggccttcgc  480
ggagagatc  ccaagatcc  ggtggcagg  gataccatg  acagtgtga  gcagagcgc  540
gccctgtgc  tgttgcgcc  gtacaggac  tcacctgac  tagttccta  gggcgactg  600
acatcccgt  tggtacacc  cctcaatga  cagcacttg  gtgtagtga  tgccgcaac  660
agcctcatc  ccacactgg  ccagaagaa  cctgaggag  tcaagacct  tgtctctct  720
gctgtctct  gactgagca  aattgtgac  tccgcgtca  cagatcttc  ggattatac  780
tactacttt  tcccggctc  ttggctgtc  gtcaaactt  tgagactgc  gcagtgcta  840
ccaccccca  accctgcgg  gcgtggccg  ctgactgag  gcttggaga  catcctgaa  900
aaggcccag  agcccccca  gtccaagaa  gtccagcat  caaatgcca  gaacgctgt  960
ctgtttgag  ccatcagcc  catcatcca  catgacagt  agcccaacc  cctggtccg  1020
gcctgcaac  agctgggcc  gttcctgca  catcgggag  caaacctgc  ctacctggc  1080
ctggagagc  tgtgcacac  ggccagctc  gagttctct  acgaggctg  caagaccca  1140
atcgagact  tcatcaatg  cttgaagac  gaacgagat  tgagtgtgc  gcagcgggc  1200
gtggacctg  tctacgcca  gtgcgaccg  agcaacgcc  agcagattg  ggctgagat  1260
ctgagctac  tagaaacag  tgactactc  atccgggag  aaattgtgc  gaaggtggc  1320
atccttgct  agaagtatg  agtggacta  acttggtat  tggacacca  cctcaacct  1380
atccgcatt  caggcgact  tgtgagcga  gaggtgtgg  accgcgtca  ccagattgt  1440
atcaatcgc  atgatgtgc  gggttatgc  gccaagacg  tatttgagg  attgcaggc  1500
ccagcatgt  atgagaact  ggtcaaagt  ggcggctac  tcctgggcg  gtttggaaa  1560
ttgatagcg  gagacccac  atccagccc  ctgatccag  tcaacctgc  ccactccaa  1620
ttccacttg  gcagcgtcc  cactcgggc  ctcctgctg  ccacctaca  caagttcgt  1680
aacctcttt  cagaggtaa  ggctaccat  caggacgtg  tgcgcagtg  cagccaact  1740
aagaacgca  atgtggagc  gcagcagcg  gctgtggag  acctgcgac  gagtactgt  1800
gccagcact  atatcctgg  aactgtcct  gaagaaatg  cacccttcc  tgagcgtga  1860
tcctccatc  tggccaagc  gaagaagaa  aagggccca  gcacagtga  tgacctgga  1920
gagaccaag  gtgagcgaa  catcgatgt  aatgggggc  ccgaacccg  tccagccag  1980
accagtgct  cgtccacac  ttctccatc  gcagacctg  tgggtctgg  ggccgttcc  2040
cctgctccc  cagggcccc  tccctcctc  ggcggtggg  tactggtgg  cgtgttctc  2100
gactcagct  ctgcagttg  acctcttgc  cccggctct  aagacaact  tgccaggtt  2160
gtttgtaaa  acaatggtg  gttgtttga  aaccagctg  ttcaaattg  actgaagtc  2220
gaatttcgg  agaatttag  tcgaatgtt  atattttat  gtaacaaga  ctccacgca  2280
ttcctaaac  ttactccaa  actaatctg  gctgacgac  ttcagacta  tctgaacct  2340
cagactaag  ccgtggacc  aactgtgga  gggggcgca  aggtgcaac  ggtgatcaa  2400
attgagtgt  tatctgatt  tacagaggc  cctgtcctc  acatccagt  caggtatgg  2460
ggtaccttc  agaatgttt  tgttaagct  cccatcact  tcaacaaat  tttccagcc  2520
acagaaatg  cttctcagg  tttctttca  cgttggaag  agttgagca  tccacagca  2580
gaagtgcag  atatcttca  agcaaagca  ccgatggac  cagaaatca  taaagcgaa  2640
attattgga  ttggttctg  gctcctgga  gaagttgat  caaaccctg  aaattttgt  2700
ggtgctggc  taatacata  caaaaccac  cagatcggc  gcttgttgc  cctggagcc  2760
aacctgcaa  ctcagatgt  cagactcac  ttgcgtacc  gcaaagaca  cgtctctca  2820
agactatgt  aattgctgt  ggaacagtt  taatccaca  accagaaga  caggctctt  2880
gtttgtgcg  ctctctcgt  tctctcgtt  gtctttgta  cacactgca  ataaacacc  2940
cttgtctga  aactgccat  caaggcacc  ccagtccta  acctacagc  agcccctgg  3000
tgtgaaggg  atgcaggac  cagtttgag  agggctgca  caggcctgc  ccgtcaaag  3060
agggtgcct  ggcctggga  atcaaggca  tcctgtggt  caacctaca  3109



<210> 9552
<211> 937
<212> PRT
<213> Rattus norvegicus
<308> P18484
<400> 9552

Pro Ala Val Ser Lys Gly Glu Gly Met Arg Gly Leu Ala Val Phe Ile 
  1               5                  10                  15
Ser Asp Ile Arg Asn Cys Lys Ser Lys Glu Ala Glu Ile Lys Arg Ile 
             20                  25                  30
Asn Lys Glu Leu Ala Asn Ile Arg Ser Lys Phe Lys Gly Asp Lys Ala 
         35                  40                  45
Leu Asp Gly Tyr Ser Lys Lys Lys Tyr Val Cys Lys Leu Leu Phe Ile 
     50                  55                  60
Phe Leu Leu Gly His Asp Ile Asp Phe Gly His Met Glu Ala Val Asn 
 65                  70                  75                  80
Leu Leu Ser Ser Asn Arg Tyr Thr Glu Lys Gln Ile Gly Tyr Leu Phe 
                 85                  90                  95
Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu Ile Arg Leu Ile Asn 
             100                105                110
Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn Pro Thr Phe Met Gly 
         115                120                125
Leu Ala Leu His Cys Ile Ala Asn Val Gly Ser Arg Glu Met Ala Glu 
     130                135                140
Ala Phe Ala Gly Glu Ile Pro Lys Ile Leu Val Ala Gly Asp Thr Met 
 145                150                155                160
Asp Ser Val Lys Gln Ser Ala Ala Leu Cys Leu Leu Arg Leu Tyr Arg 
                 165                170                175
Thr Ser Pro Asp Leu Val Pro Met Gly Asp Trp Thr Ser Arg Val Val 
             180                185                190
His Leu Leu Asn Asp Gln His Leu Gly Val Val Thr Ala Ala Thr Ser 
         195                200                205
Leu Ile Thr Thr Leu Ala Gln Lys Asn Pro Glu Glu Phe Lys Thr Ser 
     210                215                220
Val Ser Leu Ala Val Ser Arg Leu Ser Arg Ile Val Thr Ser Ala Ser 
 225                230                235                240
Thr Asp Leu Gln Asp Tyr Thr Tyr Tyr Phe Val Pro Ala Pro Trp Leu 
                 245                250                255
Ser Val Lys Leu Leu Arg Leu Leu Gln Cys Tyr Pro Pro Pro Asp Pro 
             260                265                270
Ala Val Arg Gly Arg Leu Thr Glu Cys Leu Glu Thr Ile Leu Asn Lys 
         275                280                285
Ala Gln Glu Pro Pro Lys Ser Lys Lys Val Gln His Ser Asn Ala Lys 
     290                295                300
Asn Ala Val Leu Phe Glu Ala Ile Ser Leu Ile Ile His His Asp Ser 
 305                310                315                320
Glu Pro Asn Leu Leu Val Arg Ala Cys Asn Gln Leu Gly Gln Phe Leu 
                 325                330                335
Gln His Arg Glu Thr Asn Leu Arg Tyr Leu Ala Leu Glu Ser Met Cys 
             340                345                350
Thr Leu Ala Ser Ser Glu Phe Ser His Glu Ala Val Lys Thr His Ile 
         355                360                365
Glu Thr Val Ile Asn Ala Leu Lys Thr Glu Arg Asp Val Ser Val Arg 
     370                375                380
Gln Arg Ala Val Asp Leu Leu Tyr Ala Met Cys Asp Arg Ser Asn Ala 
 385                390                395                400
Gln Gln Ile Val Ala Glu Met Leu Ser Tyr Leu Glu Thr Ala Asp Tyr 
                 405                410                415
Ser Ile Arg Glu Glu Ile Val Leu Lys Val Ala Ile Leu Ala Glu Lys 
             420                425                430
Tyr Ala Val Asp Tyr Thr Trp Tyr Val Asp Thr Ile Leu Asn Leu Ile 
         435                440                445
Arg Ile Ala Gly Asp Tyr Val Ser Glu Glu Val Trp Tyr Arg Val Ile 
     450                455                460
Gln Ile Val Ile Asn Arg Asp Asp Val Gln Gly Tyr Ala Ala Lys Thr 
 465                470                475                480
Val Phe Glu Ala Leu Gln Ala Pro Ala Cys His Glu Asn Leu Val Lys 
                 485                490                495
Val Gly Gly Tyr Ile Leu Gly Glu Phe Gly Asn Leu Ile Ala Gly Asp 
             500                505                510
Pro Arg Ser Ser Pro Leu Ile Gln Phe Asn Leu Leu His Ser Lys Phe 
         515                520                525
His Leu Cys Ser Val Pro Thr Arg Ala Leu Leu Leu Ser Thr Tyr Ile 
     530                535                540
Lys Phe Val Asn Leu Phe Pro Glu Val Lys Ala Thr Ile Gln Asp Val 
 545                550                555                560
Leu Arg Ser Asp Ser Gln Leu Lys Asn Ala Asp Val Glu Leu Gln Gln 
                 565                570                575
Arg Ala Val Glu Tyr Leu Arg Leu Ser Thr Val Ala Ser Thr Asp Ile 
             580                585                590
Leu Ala Thr Val Leu Glu Glu Met Pro Pro Phe Pro Glu Arg Glu Ser 
         595                600                605
Ser Ile Leu Ala Lys Leu Lys Lys Lys Lys Gly Pro Ser Thr Val Thr 
     610                615                620
Asp Leu Glu Glu Thr Lys Arg Glu Arg Ser Ile Asp Val Asn Gly Gly 
 625                630                635                640
Pro Glu Pro Val Pro Ala Ser Thr Ser Ala Ala Ser Thr Pro Ser Pro 
                 645                650                655
Ser Ala Asp Leu Leu Gly Leu Gly Ala Val Pro Pro Ala Pro Thr Gly 
             660                665                670
Pro Pro Pro Ser Ser Gly Gly Gly Leu Leu Val Asp Val Phe Ser Asp 
         675                680                685
Ser Ala Ser Ala Val Ala Pro Leu Ala Pro Gly Ser Glu Asp Asn Phe 
     690                695                700
Ala Arg Phe Val Cys Lys Asn Asn Gly Val Leu Phe Glu Asn Gln Leu 
 705                710                715                720
Leu Gln Ile Gly Leu Lys Ser Glu Phe Arg Gln Asn Leu Gly Arg Met 
                 725                730                735
Phe Ile Phe Tyr Gly Asn Lys Thr Ser Thr Gln Phe Leu Asn Phe Thr 
             740                745                750
Pro Thr Leu Ile Cys Ala Asp Asp Leu Gln Thr Asn Leu Asn Leu Gln 
         755                760                765
Thr Lys Pro Val Asp Pro Thr Val Asp Gly Gly Ala Gln Val Gln Gln 
     770                775                780
Val Ile Asn Ile Glu Cys Ile Ser Asp Phe Thr Glu Ala Pro Val Leu 
 785                790                795                800
Asn Ile Gln Phe Arg Tyr Gly Gly Thr Phe Gln Asn Val Ser Val Lys 
                 805                810                815
Leu Pro Ile Thr Leu Asn Lys Phe Phe Gln Pro Thr Glu Met Ala Ser 
             820                825                830
Gln Asp Phe Phe Gln Arg Trp Lys Gln Leu Ser Asn Pro Gln Gln Glu 
         835                840                845
Val Gln Asn Ile Phe Lys Ala Lys His Pro Met Asp Thr Glu Ile Thr 
     850                855                860
Lys Ala Lys Ile Ile Gly Phe Gly Ser Ala Leu Leu Glu Glu Val Asp 
 865                870                875                880
Pro Asn Pro Ala Asn Phe Val Gly Ala Gly Ile Ile His Thr Lys Thr 
                 885                890                895
Thr Gln Ile Gly Cys Leu Leu Arg Leu Glu Pro Asn Leu Gln Ala Gln 
             900                905                910
Met Tyr Arg Leu Thr Leu Arg Thr Ser Lys Asp Thr Val Ser Gln Arg 
         915                920                925
Leu Cys Glu Leu Leu Ser Glu Gln Phe 
     930                935



<210> 9553
<211> 31737
<212> DNA
<213> Homo sapiens
<308> AC006942
<400> 9553

gatcatgcc  ctgcactct  gcctgggtg  cagagcaag  ctctgtctc  aaaaaaaaa  60
agaaaaaga  aacagaaaa  aactttgga  ttggaatta  acagaatgt  aaagaagta  120
atttcatat  tttcaataa  taagagaag  attttaaaa  atgagtaaa  tttaagcag  180
tttgaaaat  taattgaaa  agtcaaaaa  tgccaggca  agtagtggc  tacacctat  240
atccaggca  tttgggagg  tgaggtggg  ggatcactt  aggccggaa  ttcaagatc  300
gcaacatag  gagacccta  tgccacaaa  actaaaata  tagccgggt  gggtgctgt  360
tgcctgggt  gtccatcca  gaggctgag  caggaggat  gcttgagcc  gggaggatg  420
ggctgcagt  agctatgat  tcatcactg  actctaacc  gggtgacag  gtaagaccc  480
gtctaaaca  acaaacaaa  aaaaccaaa  aacaaataa  tgtttaaaa  attaaaaat  540
aggtgtctg  atttagtta  cagagtagg  acagccaaa  ccagaatta  tggcctggc  600
gtagaactg  agaaagaca  caaaatgca  cccaaagaa  acaaagcga  ggggatttt  660
ggaaagaga  aaagactca  ggaagacag  gaacatcta  cagaattgc  atttagagt  720
gtagggaga  atcgtgaca  aggcagtgt  cgaagagag  taatggttg  aaatattcc  780
gaatggatg  aagaggctg  tccccagat  caaataggc  aggaaatca  aagcaaaag  840
acagactgt  gggggtgac  gtggggcag  aagaccagc  aggcatctg  caccaggtc  900
aggtcagag  tcgcggtgg  ttggaccag  gctgtggcg  tcatgtggt  atgagaagg  960
catgtttcg  gagtagagt  gatggatta  atgtgctgt  ctaggatga  gtggggaca  1020
tgaacaggt  agtgaatga  ggcagacct  tcagcaatg  gacaaaggc  ataggaaaa  1080
gggtcagag  gggcagaac  tgagtgtgg  ttggtcatg  tgaatttga  atgtgtatt  1140
gacatctga  taggactct  gggaggaag  tggattgca  ggagtcagg  cgggaggga  1200
agagatctg  gagagatcg  caccgtcca  taaaaatat  atgcaaaat  caggccagg  1260
acagcagct  acacccgta  tcccagcac  ttgggaggc  aaggtgggc  gatcacttg  1320
ggtcaggag  tcaagaaca  cttggccaa  gtggtgaag  cccgtctct  ctaaaaata  1380
aaaaattag  caggtgtgg  ggcgggcac  tgtaatccc  gctacttgg  aggcttagg  1440
aggagaatt  cttgaaccc  ggaggtgga  gttgcagtg  gtggagatt  tgccactgc  1500
ctccagcct  ggtgacaga  cgagactcc  tctcaaaaa  aaaaaacat  agtggggtg  1560
agtggtgca  acctgtagt  ccagctact  aggaggctg  ggcaggaga  tcgcataaa  1620
ccggggggc  gaggttgca  tgagccgag  ttgcaccac  gcactccag  ccgagtgac  1680
gagtgagac  ccatcttaa  aaaaaacaa  caaacaaaa  gcaaaatac  aatgtgtgc  1740
tgtaatccc  gctactcga  tgactgaga  gggaggatt  cttgagctc  agaggccca  1800
gctgcagtg  gctgtgatc  tgcctaggt  acagtgaca  cctgtctaa  aaaaatata  1860
tgcaagcca  ataggtgtt  ttctgtttt  tagtattta  tatttcagt  taacctgat  1920
cacacaaaa  attatcact  tgacactga  tcagcgtaa  aattattca  gagctattt  1980
atttgacat  tgtgtttgg  gctaagtct  tggaatgcg  cgttgcggg  gtctctcag  2040
ttggactcg  tgcagttcc  gtgctctgg  ggctgttgt  tctgacagc  tggggattg  2100
tggcagtta  gctcgggcc  ggtgaagcc  ctgagggca  gtgttaact  ggaattccc  2160
aaagctggg  ccttgagtg  ccctggtgc  gcccagcgt  ttacgctct  gcagggggg  2220
tgggagtca  gatcagggg  gtgggagga  aatcaggat  aggccatga  tcagaatgc  2280
aagaacttt  atggaggag  gagtggcca  tcgcaaatg  tgccagcag  ttctttagg  2340
caaggacag  cagtcagca  cagcttggg  gagacagag  ttacaagcc  ccctgaaga  2400
ggaagaacc  ggcactttg  ggactgaga  ggaggccac  gtggccaac  tgtgtgggt  2460
cagatgaca  tgtccctgg  gtggatgcc  aggggtggt  ctctgccag  gtcaagggg  2520
cagggtggg  ctgtctggc  ctaggctgc  ccctccaca  tggaaactt  gcctcagca  2580
tgactgggg  acgaaggaa  tttattttg  aggtagact  ttatttaac  ttttatttt  2640
tggagacag  gtcttgccc  gttgcccag  ctggagtgc  gtggcacag  cttggctca  2700
tgcaacctc  gactcctgg  ctgaagcga  cttcccacc  cagccccct  agtagctgt  2760
attataggc  tgcaccacc  tgcctggct  atttttgta  ttctttttt  ttttgtaga  2820
atggggttt  gctatgttg  ccaggctcc  ggctggtct  gaactccag  gctcaagca  2880
tcctcctgc  tcagcctcc  aaagtgttg  gattacagg  gtgagccac  actcccatc  2940
aggcttttt  tgtttgttt  ttttgtttt  tgttttttt  tttttgagg  agtctctct  3000
tgtcaccca  gctggagtg  agtggtgca  tcttggctc  ctgcaacct  tgcctccca  3060
gttcaagca  ttctcttgt  tcagcctcc  gagtagctg  gattacagg  gtgtgccac  3120
acacctggc  atttttttt  tttttttag  agagacgag  tttgccatg  tggccagac  3180
ggtctcaaa  tcttgacct  tattgatcc  tctgcctca  cctcccaaa  tgctaggat  3240
acaggcgtg  gcctctgcg  ccggtcatt  taaccattt  aaggtgttc  gttcagtgg  3300
ttctagtat  ttgatgatg  tgtgcaaca  ccactacca  ctaattgca  aacactcat  3360
gctccaaaa  aagactctg  acccattag  agtccctcc  cattccctc  tccccccag  3420
ccctggctg  caccaatct  ctttctgtc  cagatttgc  taatgtgga  atttcatag  3480
aatggaacc  cacagtagg  ggccttctg  gtctggctt  ttccactca  caagatgtt  3540
ttcaggttc  tccacattg  ggtgcatat  cgtgatttg  tcgagatag  gtctcactc  3600
gctgcccag  ctggagtgc  gtggcatga  catagctaa  tgcagccct  acctcccag  3660
ctcaggtga  cctcccacg  cagccactc  agcagccgg  actacaggc  caagccacc  3720
ggcctggct  atatttgaa  tttttatag  gacagggtc  cactatatt  cccaggcta  3780
tcttgaact  ctgagctca  gtgatcctc  gtggcctca  cttcccaaa  tgctgagat  3840
acaggcgtg  gccaccgcg  ctgacttgt  gttttattt  ttatacttg  atatgcagc  3900
tgatattgt  tagtttaac  ttttcctaa  tagcgccat  gcccttatt  cacttaacc  3960
agttgataa  tagctctta  tcctttgtg  ggtatcctt  tctgtaaat  gagatgata  4020
aatccgcgt  cttagaggg  tgtggtggg  agcgagcga  ctgtgcggg  acacttaga  4080
cagagtttg  cccagagtc  ggactcggg  gatgcgctg  ggctcagga  atgtgtgcc  4140
tggcagcga  gggaaagtg  cccagagtc  gggctcggg  gatgcgctg  ggctcagga  4200
atgtgcgcc  tggcagcga  gggaaagtg  cccagagtc  gggctcggg  gatgcactg  4260
ggctcggga  atgagcgcc  tgacagaga  gggaaggtg  cccagagtc  gggctcggg  4320
gatgcgcgc  gtgacggag  tgggaaagt  gcctggagt  agggctcgg  agatgtgcg  4380
tgtgacgga  gtgggaaag  gccgtcaca  atggagcat  gtctgtggc  aggcttctt  4440
ctggtttct  gttctaact  gatgaccac  gggcagtga  cgtttctgt  gggtgagcg  4500
ctgggggca  cactgctgg  cttggtctg  tgcacacac  gcagtggcc  ttctagaca  4560
aggaagccc  gagcctctc  agagggcct  tccctgtgt  cgcctccag  tgcagcaca  4620
gagggttcc  agcacttta  gaggccgta  caacaggcg  cagtcgggc  agtatctgc  4680
tggatgacg  caggagcca  ctgctgggt  gctgcacat  cagtgagac  tgctgccac  4740
ggcctttga  tcgtgcagg  ctcccctct  aggacttct  ccctgtgtc  tttgctgtc  4800
gttgggtgc  ttctgggaa  ccctttact  ataggccat  gctgggcca  tcttgacag  4860
tcccagcac  tcctcttac  caaggctat  gccatgcac  acacaatct  atttctgtt  4920
ttttttgag  cggagtctc  ctctgtctc  caggttgaa  tgcaatggt  agatctcag  4980
tcactgcaa  ctctgcctc  caggttcaa  cgattctcc  gccccagcc  cccgagtag  5040
taggatttc  ggcacgtgc  accatgccc  gctaatttt  gtattttta  tagagatgg  5100
gtttcacca  gttggccag  ctggtctca  actcctgac  tcaggtgat  cacctgcct  5160
agcatccca  agtgctggg  ttataggtg  gagccactg  gcctggcct  ttttttttt  5220
tttttttgt  gagacaggg  tttaccacg  tggcctggc  aggccggtc  caaacacct  5280
gcctcaagt  atccgcctg  ctcagcctc  caaagtgtt  ggattacag  tgtaagcca  5340
catgcctgg  ccaccatct  atttctttc  ccccaaagc  gacaaggct  ctcattttc  5400
tgaagggga  acagcccat  agagagggt  agtggctta  ccccatctg  gccccacag  5460
cacaacctc  tgcaggcgt  tctgacccc  gaaggtgct  ccctgggat  ctcttctag  5520
acaacatca  gctccatgc  ctttgctgt  ctaggagct  ggttatggt  ggggcctgg  5580
gtcagccct  tgagatggg  tgcccgctg  ctgccaggt  ctgtgccag  caagtgctg  5640
ccctggttt  ctgtgactg  tgtgatgaa  taccaccag  acagcggtg  caaacaccg  5700
ttctggatg  cggaagtcc  acatccatc  cacggggct  aaatcaagg  gtgggcagg  5760
ctcgtccct  ccgggggcc  tagaggaga  gccgcgtcc  tgccttctc  agctcctag  5820
ggccacctg  tttccttgg  tcgtggccc  ttcccccat  cccaaaggc  gcagtgtgg  5880
atcttctct  ctgcctgac  tctgttcca  cctcacatc  tctctgact  tgaactgta  5940
ctttccctt  taaggaccc  gtgatgaca  tgggtccac  tggatcacc  aggatcctc  6000
ctccatctc  tgatcctta  ctttatcat  tctgcaaag  acccccacc  ttttttttg  6060
ttggagaca  ggtcttgct  tgccaccca  gctgcagcc  tcacctccc  ggctaaagc  6120
atcctccca  ctcagcctg  caagtaggt  ggtctacag  catgcgcca  cacgcttgg  6180
taattctca  atttctagt  gagatgggg  tctcaccat  ttgcccagg  tggtctcca  6240
ctcttgggc  caagtgatt  tcccacctc  gcctcctaa  gtgctggga  tacaggcgt  6300
agccaccct  acccccaga  cctgtgaat  tattccctt  gattcaaaa  agccttgca  6360
agtctgttc  ctcacaaca  gcagaggga  cctttaaaa  cctaagcca  atcaaaaat  6420
cacccattt  ctcagtttg  tgtggagag  agataaacg  gtgaatcca  ccagagacc  6480
gtgggagtg  tggacaggc  gaaggggtc  gggggcagc  gttcctgct  tcgtgttaa  6540
atcacgctg  ttctctgct  accacccac  gcggctttc  tctcccaat  ggtaaaaag  6600
caagtcctc  cttcagcca  caaggccct  cagggtctg  ctctctgtt  cctccctgt  6660
ctatctgca  ccctcctgc  ccatggctc  ggccgcagc  tgcaggcct  cttgctgct  6720
ctcctacac  cgggctccg  cttcctgat  gccttggca  aggctgttc  ctctgcctg  6780
gatgttctg  tgcagagga  tttcagtct  tcctcctta  gttactctg  tttgtttat  6840
tttaaattt  tttatttat  tagagacag  tctaactct  ttgcccaag  tagagggag  6900
gcagtggca  agtcatggt  cactgccgc  tcgacctcc  agtctcgag  aatcctccc  6960
cctcaccct  ccgagtagc  gggattaca  gcctgcgcc  ccacaccca  ctaattttt  7020
tatttttga  gagactggg  ctcactgtc  cccaggctg  tcttgaatt  atggcctca  7080
gtgatcctc  cacctcgac  tcccaaagt  ctgggatta  aggcgtgag  caccatgcc  7140
agccctgac  gtatttgat  tatgtgttt  cgtggtgct  tctgaaatg  aagccctgt  7200
aggacaagt  tttggacca  tttattcac  actctatcc  tggagtgaa  agcagtgcc  7260
ggtacccca  gggcaccca  taggtgctt  gtgaatgaa  gaaggtgca  agccaggct  7320
gacatgttc  tgagccctg  gaggttact  agatgcaat  attttgcag  tgaagacac  7380
gagtcctgg  gggccgtga  gtcagcgcc  gactggatc  tgcggccgc  tggctgtct  7440
tccctctcg  tggcctcgc  cacccttcc  gggaggaac  ggagaggag  ggaggtgtg  7500
agggctggg  tcactgact  tgcttcccc  gccctgcat  gtgtcccca  agggacagc  7560
tggacagtg  caagcagag  gcggccctg  gcctccttc  actgtacaa  gcctcgcct  7620
acctggtgc  catgggcga  tggacggcg  gtgtggtac  cctgctcaa  gaccagcac  7680
tggtgagcc  ccagccctc  cacccccgg  tacccaggg  tcccacctc  gccctgacc  7740
ccctggatg  ccggggctc  cacctcagc  ctcacaccc  cggataccc  gggctccca  7800
ctcagccca  gcaccccct  gatgcccgg  gctcccacc  cagccctca  gcccccgga  7860
acccagggc  cccacctca  ccctcacgc  ccctggatg  ccagggctc  cacctcagc  7920
ctcacgccc  cggataccc  gggctccca  ctcagccct  acgcccccg  atacccagg  7980
ctcccacct  agccctcac  ccccctgga  gcctggggc  cccacctca  ccctgatcc  8040
cctggattc  tggagcttc  ccctcggcg  tgacgttca  cagacacca  aaaccatga  8100
ccagtgtcc  cggtactca  tacctgccc  agtgtccag  aaccctccc  tccccatct  8160
tgacactcc  ctggctggc  agggatcct  tccagtgac  cccacaccc  tcaccaacc  8220
cccagtccc  tagaaaatc  cactctgtt  ctaatacct  gagattccc  caacagcgc  8280
catcacctg  gcaccagcg  agaaacctt  actgtccca  ccccacagt  ccaaccctc  8340
agagtctcg  cccttcact  ctccttacc  agctgcctg  ggtcctgcc  gggacaccc  8400
acacaccca  gtcagtgct  gccatggcg  ccgaggccc  gtggcctcc  caccccacc  8460
ctaaagcac  cacagtgac  catgtgcac  cccctaaac  ccatcttcc  gactgcaca  8520
acatcccga  cctgtcccg  tcctgagcc  ctgctctca  gtaccacct  ccccagggg  8580
ctgacttgt  tctcctctg  ccctgcagg  tgtggtcac  gccgccgtc  gcctcatca  8640
ctgtctctg  aagaagaac  cagatgact  caagacgtg  gtctctctg  ctgtgtcgc  8700
cctgagccg  gtgggtgtg  cctagatat  ggctgctgg  ggtggccct  gcatcccta  8760
gccctctga  acccctcag  cccccactc  ccctgagag  cagcccagc  caaggttta  8820
aaactcagg  tctgagctg  attcatcct  gctcggcct  ttcctggct  ggtggccct  8880
gacaagtgg  ttcacctcc  tggcctcag  tgccccctg  gttcagtgg  gataatacc  8940
gtgcccacc  ggaggcaca  agcgctgtg  atagagtgc  cagaacagg  cctcgcggg  9000
cgagcaccc  gggagccag  cgccctcat  acctcctcc  tctcccact  ctctctctg  9060
ctcccactt  ccctcttct  gctttgcct  ccgcctctc  ctttcctgt  cagcctctc  9120
ctcctgcct  gcgtccctc  cccaccttt  ctcctgtcc  gcccaggaa  atcccctga  9180
gccttgtgc  tgccaggct  catgtcggg  gacaccagg  acacagatg  gtcagaacc  9240
agctctgct  ttaaggagc  ccctgtcct  ctggcaggg  ggtgactca  tcacagatt  9300
tcagaaaag  ggtgactcg  gctataatg  aggtaggat  ggtcaccca  aggaggcac  9360
taacacagc  tgtgagtcc  cgaaggctt  ctgggggcg  cgatcccag  attgagact  9420
agaatacac  tgcgcatct  ctgggcagt  aggaagagg  ctggattcg  aggcaaaga  9480
aagaacaca  cagctcgtg  atccactca  tgtttcttt  ttttttttt  ttttttttt  9540
tttgagacg  agtctcgtt  tgtccccag  ctggagtgc  gtggcgcga  ctcggctca  9600
tgcaagctc  caggttcac  ccattctcc  gccttagcc  cccgagtag  tgggactac  9660
ggcgcctgc  actatgccc  gctaatttt  tgtattttt  gtagagaca  ggtttcacc  9720
tgttagcca  gatgatctc  atctcctga  ctcgtgatc  acccgcctc  gcctcctaa  9780
gtgctggga  taccggcgt  agccactgc  cctggccca  tcattgttt  tttctcagg  9840
ttttttttt  tttgagaca  ggtcttgct  tcgcccagg  tggagtgca  tagtgcagc  9900
atggttcac  gcagcctct  gctcctagg  tcaagcgat  tctcgcctc  gcctcccga  9960
tagctggga  tgcaggtgc  tggctaatt  ttgtatttt  tgtagagat  ggtcttgct  10020
tgtcgccca  actggtctc  aactcctgg  ttcaagtga  cctcccgcc  cagcctccg  10080
aagtgctgg  attacaggt  tgagccact  cactcagcc  cagtcattg  ttcattcat  10140
catcacaca  ctgagtact  cagtgtgcc  ggatgacag  gaggtagga  cacagacca  10200
cacggaggt  ggacagagc  tcctggaga  gggcttttc  aggttgaat  ggagtttgc  10260
atgaggaaa  aaagtcaca  gatctttct  tttttttga  atggagttt  gctcttatt  10320
cccaggctg  agtgcaatg  cgtgatctt  gctcactgc  acctctgcc  cccgggttc  10380
agcaattct  ctgcctcag  ctcccaagt  gcatggatc  caggcatgt  ccaccacgc  10440
cagctaatt  ttgtatttt  agtagagat  gggtttcac  atgttggtc  ggcttgtct  10500
gaactcctg  tctcaggtg  tccacccac  ttggcctcc  aaagtgctg  gattacagg  10560
gtgagccac  gcacctggc  atgatcttt  aatctttca  taattccct  cctcttccc  10620
gaacctctt  ctatctgac  ttgtattag  cctagggac  caaaaaagg  tcagaccca  10680
tccctgccc  tgagtggct  caagccttg  agggggact  caggaaaca  cctccagga  10740
ccggtgcgc  gtgtgctct  acggaggaa  cctggggca  gggaggctc  gagccgagt  10800
aggaggggg  cctgggaaa  tgtcacaca  aagggaacc  gcagagacc  ttcctgccc  10860
ccacacacc  gcattactt  gaaagatca  ccagccggg  ttagtccta  ttttgcccc  10920
attcagtgt  cctgacgct  cctcgctcc  ttcccagag  ctcagattc  tgcttcata  10980
aaccattgc  ttggtcggg  atggtggct  atgcctgta  ccccaggac  ttgcgggac  11040
gaggtggga  aattgcttg  ggccatgag  tcgagacca  cctgggcaa  atagtgaga  11100
cctgtctct  caaaaaaaa  ccactaaca  aaccattaa  actgacagc  ctgcccttg  11160
aaggcacca  ttgctccac  ctggcatgt  gacccacgt  cccctccca  cccagcccc  11220
aacttattt  ttgctcttc  ccgccagat  gtctcctct  cctccaccg  cctccagga  11280
tacacctac  acttcgtcc  agcaccctg  ctctcggtg  agctcctgc  gctgctgca  11340
tgctacccg  ctccaggta  tgaacgccg  gcactcccc  acccggggt  gcctgctgc  11400
ggcatctgg  ggcctcctg  tccacggcg  accaggtgg  actggaggg  ctgggtcag  11460
atttctctg  agctggggc  gttcctctg  ccccttacg  ggctgcact  ggggaggca  11520
gcaggcagc  cgaggccca  cgcctaccc  gtgcagcat  gtggatcag  ctcatagct  11580
aggtccctg  tacccgggc  ctcactcca  ccctgttgc  agggactgt  aactgtgcc  11640
gttttatag  tgaggaatc  gaggcttgg  gagggagct  ctggcccag  gtcactcac  11700
cggtcagtg  gtgattcca  gccgtgcta  ctgaattac  atagccctg  caggggttt  11760
cacatctgt  gggaacctt  ccctactgc  cacagtcac  atagccagt  tgtatgaaa  11820
tcctgtagt  agccaggca  tgggcaggg  gcacctgca  ctgccgaac  gagctggca  11880
ggaggaaca  ccagtgtga  atgcacaca  ggaaactga  gcttggagg  gagacatca  11940
cattctagg  agtaagtgg  agttggccc  cagactctc  gctctaaac  cctccctct  12000
ccactgagc  cccccgagc  tctgtcgcc  tggctgact  acctcatgg  gcagtttct  12060
cggaccctg  gctgagggg  ttggcacac  gtaggtgct  atgcaccag  tccctccat  12120
cagccagca  gtccagcac  tgccagggg  cagggctga  gtacaccac  aaatctctg  12180
gtgtgcatg  ctgtctgtg  gcatgcctg  atgcgtgca  gcgttcgcc  gtgtgtgtc  12240
atacctgcc  gtgtgcatg  atgtctgcg  gcatcccct  tgtgtggat  tgtcattgt  12300
tgtgcatct  tatgtatgc  tgtctgtgt  tatatgtgg  agtgttcat  gtatctctg  12360
gtccctcta  gtgtgtaca  gtgtatata  cagtgtgtg  atctacatg  gtacctgtg  12420
atgcaagtg  atgtgtaca  gagtgtaga  acctgtgtg  atgcctgtg  gtgcgtgtc  12480
caatgcttg  cagcatcta  gtgtgtcca  gcatgtccc  ctgcacatg  tgtgtgtgt  12540
cacactctg  gtatacgat  tggaggtga  accagaggc  catcgtgtg  gaagccagt  12600
atgaattct  ttgtgtggc  ctggggaca  gtcttcctt  tctgggcct  tttttcgtc  12660
tgtcaagaa  ggcttaagt  atgctctaa  cccatgacc  ccccagaag  cccagctgg  12720
aattctggg  tacacccat  gcaggcacc  cacccactc  aaccctcgg  ggtgtagga  12780
ctggagaca  agccttgtc  tgaggctgg  cctgaggac  caccaaccc  gtgtcacct  12840
cttttcagc  aatggtggt  ggctattgc  aatttgttt  caagtcatt  ttttgtcat  12900
tgcattatg  aaagtttcc  agcatccag  taagtacag  gatttcatt  cttggactt  12960
acattttgc  atgtatgca  gctcttgtt  attttcttc  gaaatattt  aaagtaaat  13020
acagacatc  tgatgtttt  cctttaaat  tgttgttct  ggccaggca  agtggctca  13080
gcctgtaat  ccagcaatc  gggaggccg  ggtagaagg  tcacttgag  tcaggaatt  13140
gagaccagt  tggccaaca  ggcaaaacc  catctctac  aaaaataca  aaaattagc  13200
aggtgtggt  gtgcatgcc  gtagtccca  ctactcagg  ggctgagat  ggaagatcg  13260
ttgaacccg  gaggtggag  ttgcagtga  ccaagattg  gccactgca  tccagcttg  13320
gtgacagag  gagactctg  ctcaaaaaa  aataaaaaa  taaaaaaac  gaatatata  13380
cacagtaca  tctaggatc  catattcaa  cggattctg  caggctcag  ggctaacac  13440
gtcatccca  cactttggg  ggctgaggc  gaaggatcg  ttgagccca  gagtttgag  13500
tcagactgg  caacatagt  gccctgttt  caaaaaata  gatttaaat  ggattctgt  13560
tttgttatt  ctcgtagtc  ggactagcc  ccctacacc  gtttatgga  aaaccagga  13620
atgccattg  tgtgtgtcc  atggtggcg  ctgggctca  tgctgcctt  tggtgtatt  13680
tagcttgtt  ctctatctg  tgaattttc  tgcggaaaa  tctgcagaa  aatctgcgg  13740
accattttt  gctggaacg  ttgacagct  ttgcataca  ttgaaaaca  gtcacattc  13800
aggaaacgt  gtgattggt  ctcctgtga  ctgctggct  gcatctgtc  gtggtggag  13860
gctctgggg  gtgaggggg  acctggttg  gccttgtct  ctttggcct  ccagcctct  13920
ggccaggag  atggcaccg  gtgtgcctg  agtggcctc  tgctgaatg  acacttggg  13980
gggtggctt  tgcattttt  tcaggggct  ctcagcact  acaccagtc  ttgggaagg  14040
ctgggtttg  gggcacctc  ggggaaggt  cctggagct  cctttgctc  gtgagaaac  14100
taaggagcc  cagagctgc  gatgaggaa  ctgaggctc  catggtgcc  cctcttgcc  14160
gagagggtc  gagcaggag  agagcccag  tctggggat  gatcttgtg  ctccagagg  14220
gccttgtct  accatctct  ctgggctgg  aagaggttg  gggagcaga  accctggcc  14280
tgagctgca  aattctcga  tgtcagagg  accccgagc  cctcctttg  aagacagga  14340
ctggggcat  gccaccacc  cagcaggtg  gccaggtgg  caggacact  agccggggg  14400
gtccccttc  tttccccag  ggatgcggc  gtgaagggg  ggctggtgg  atgtctgga  14460
actgtgctc  acaaggccc  ggagccccc  aaatccaag  aggtgcagc  ttccaacgc  14520
aagaacgcc  tcctcttcg  gaccatcag  ctcatcatc  actatgaca  gtgcccgcc  14580
gggcctatc  gggcctgat  cctggggcc  ggaaagagg  gcatggagg  ccggactcc  14640
gagtcctag  cagagggca  ggaatcttg  cttttaggt  gggtaggag  aggatgggg  14700
tgtgaagtg  cacctgtga  gttggtgct  gggcccttc  tgggggcag  attgctagg  14760
atctttctc  gggctcaaa  gcccagttg  ctgggtcac  ggaggtgca  tactgcgat  14820
caaggccgg  aaggttaag  cctggatcc  tgggggctg  gagatgggt  agctggggc  14880
cgagtcctc  accttctcc  gtcagtttc  ctcaccatc  ctctcttgt  gcccctgct  14940
gcagtgagc  caacctcct  gttcgggcc  gcaaccagc  gggccagtt  ctgcagcac  15000
gggagacca  cctgcgcta  ctggccctg  agagcatgt  cacgctggc  agctccgag  15060
tctcccatg  agccgtcaa  acgcacatt  acaccgtca  caatgccct  aaggtgtga  15120
cccttggag  ccaccccgg  cctgccacc  ccctcagaa  gaccagagg  tcagaggcc  15180
ttgggtggc  aaccctgtg  caacaggga  tctaaaaca  acctgggct  tgctctccg  15240
cctcagacg  agcgggacg  cagcgtgcg  cagcgggcg  ctgacctcc  ctacgccat  15300
tgtgaccgg  gcaatgcca  gcagatcgt  tcggagatg  tgcggtacc  ggagacggc  15360
gactacgcc  tccgcgagg  gatcgtgag  gctgtgggg  gcgggctgg  ctcttgggt  15420
tgaggcagg  ggtggctgg  ggcctggat  cctaagtct  agggaggag  ggctggggc  15480
tggactcct  ggtctccag  tgggggcag  ggtgagccc  gatccaggt  agtgaaagc  15540
cgacatggc  tgcggcaca  tctctctca  acgccccgg  ggcaggtcc  gaaggtggc  15600
atcctggcc  agaagtacg  cgtggacta  agctggtac  tggacacca  cctcaacct  15660
atccgcatt  cgggcgact  cgtgagtga  gaggtgtgg  accgtgtgc  acagatcgt  15720
accaaccgt  atgacgtcc  gggctatgc  gccaagacc  tctttgagg  cagcatccc  15780
gaccctgac  ctatgaccc  acgacagga  ctagaggca  agcaaggat  gccggggcc  15840
tggcgcctg  cagcccgca  ccaccctcc  tctcctgca  tgccgtgac  tcaaaatgg  15900
gcctctgcc  ctctgggcc  acccagggg  cccagggct  tggtctcat  ggcctgatg  15960
gaggagtcc  cagggcatg  gcatggggc  cccagtgtg  agtcctggc  cccggatct  16020
ggtagtttc  ctctgcccc  ggaaagggg  cccacacag  cctgttttt  gtttgtttg  16080
ttgtttgtt  ctggagacg  agtctcact  tgttgccca  gctggagtg  ggagtgagt  16140
ccgtggtgc  atctcggct  actgcaacc  cggcctccc  gcgtcaagc  attctcctg  16200
ctcagcctc  ccagtagct  gtactacag  cacgcgcca  cacacccag  taatttgtt  16260
gtattttta  tagagacgg  gtttcacca  gttacccag  ctggtttga  actcctgag  16320
tcaggcaat  tgcccgcct  ggcctccca  agtaccagg  ttacaggca  gagccactg  16380
ttccggccc  cagccctgt  ttacttcct  tgtgagctt  ggcccgtca  tcaaccttt  16440
tgtgactca  tttcccacc  ataacccca  ctgcagcag  gctttcagt  ttccaccag  16500
cagtaggtg  ctgcaccca  cgatcccgg  gagggcgct  attgttgtc  tctccacgc  16560
cttccccac  ccactcagg  gctccaggc  cctgcctgt  acgagaaca  ggtgaaggt  16620
ggcggctac  tccttgggg  gtttgggaa  ctgattgct  gggaccccc  ctccaggtg  16680
gggagcctc  gcctgcagg  gagaacaca  atgcttctg  ggggtccag  gcttggggg  16740
tccccaggg  tctcagggc  ggcagtgat  ggctcccat  ctctcggcc  ccaccccaa  16800
ccacctagc  gggtaagaa  ggagcttag  cccaggatc  tggacagag  gtgactgcg  16860
cccctgtct  gtgcctggg  agggccact  ccctccagc  gcttggggt  ctgggacgg  16920
tccatccta  ggaggggca  ctctcgagg  ggtttctgg  agagggcag  ggaacctgg  16980
cccgctgac  cccactcct  cacacagcc  cccagtgca  ttctccctg  tccactcca  17040
gttccatct  tgcagcgtg  ccacgcggg  gctgctgct  tccacctac  tcaagttca  17100
caacctctt  cccgagacc  aggccacca  ccagggcgt  ctgcgggcc  gctcccagc  17160
gcgcaatgc  gacgtggag  tgcagcagc  agccgtgga  tacctcacc  tcagctcag  17220
ggccagcac  gacgtcctg  tcagagccc  gtcccccca  cccacccct  ttgcacacc  17280
ccttcccgc  ctcccctcc  cctgacccg  actgacctt  cccaccccg  ccgcgccag  17340
ccacggtgc  ggaggagat  ccgcccttc  ccgagcgcg  gtcgtccat  ctggccaag  17400
tgaaacgca  gaaggggcc  ggggccggc  gcgccctgg  cgatggccg  agggacccc  17460
gcagcaacg  catcaacgg  ggcatggag  ccaccccca  cactgtggt  agtcccctg  17520
ggtgggccc  gccagggtg  ctggggctg  gtcctgccg  gcgccgcct  tcctcaccg  17580
gacctgcgc  tcctacagt  gacgccctc  ccctccgcc  acctcctgg  gctgcgggc  17640
gcccctccc  cggcagcac  cccggcttc  gcaggagca  ggaaccttc  ggtggacgt  17700
ttcgatggc  cggccgccc  gcccagcct  gggcccacc  ccgaggagg  cttcctcag  17760
tagcacccc  tgggcccgg  ccccttctc  cggccaccc  cagggctgt  ccttctcgg  17820
ctctgtccc  gttttccct  agcccctcc  ccgcccccg  ctcgctcct  tctccatcc  17880
gatgccttc  ccagccctg  ctgctgcct  ccctgcccc  gcctccctg  tcacgccct  17940
cctctgcca  tctggactc  gccgaccct  gccaccctt  gttgtctcc  ttcctgtca  18000
cgtttctca  cctgctctt  cttttctcc  tctctcctt  cctcttccg  ccctccctc  18060
ctgtctctc  tctgccctc  cgctgccta  gtggaattg  ctgcctgcc  cgcctgtct  18120
ctcttgtct  ctctgggat  ggatggctc  gcgagctgg  gccgcctgc  cccgagagc  18180
ccatggctt  gctggctga  ccagctcca  ctgctgagt  aggggtggc  tggggtggg  18240
ggtcggtcg  gggggcgga  tcgggtgtc  ccagggaga  ttaggggac  gggagccct  18300
gtcaacggg  tcctgatga  cagcagagg  agggacttg  aggaaaggg  aacttggtg  18360
ctgccgatg  gggggcacg  gccagggtt  tattcccat  ggaggccac  gctggatgg  18420
tgcgaggtt  ctcgaggct  tgtgagggg  ctggatatg  ggttctggg  ttctgtcct  18480
agggcttgt  ctcgcactc  atcgctctg  gcctttgcc  ctccccacc  agttccttc  18540
catctcact  tgctccatg  ctccagccc  ggtcctgag  acatcggcc  tcccattcc  18600
gaagccgat  agttgctga  taagtgagt  ctgggagtg  tgggggagg  gaacgggac  18660
ggtgcggag  ccaggccag  tgcagacag  cacccccgt  atcttgcgc  ccctgcccc  18720
tcaggtttg  gtgtaagaa  aacggggtc  tgttcgaga  ccagctgct  cagatcgga  18780
tcaagtcag  gttccgaca  aacctgggt  tgtcccggg  gactgtggg  atgggtcgg  18840
gggagacct  ggggaaggg  tcagaggga  tcagatgga  ctctgcctc  cccacctac  18900
gcaggccgc  tgtatctct  ctatggcaa  aagacctcg  tgcagttcc  gaatttctc  18960
cccactgtg  ttcacccgg  agacctcca  actcatatc  tctcaggcc  ggcccagcc  19020
cctgcctct  cacgtcggc  ttcctcacc  tggggaagc  ggctgaccc  ggtccacac  19080
tctcttcag  ctctcttgg  cacgcaatt  gttctctga  attgagtgt  tgcatctgt  19140
aagatgggg  tgggattcc  tcccccagg  caggggatg  cagtgaagt  gtgtgtggg  19200
ggctttact  ccagaactc  acctgctcc  ggcctcatt  tgtccctgt  tggcacctt  19260
cgtgtcctg  catcgtcct  cactgggct  catgtcatg  tgccagcac  gcctgcact  19320
aggagccag  cctgcgggt  cagacgctg  tcaggcctg  tctgggctg  gtcactttg  19380
ctctctggg  tctcctgtc  ccgctgtga  gtgtatgta  accctcctc  tcctcatag  19440
gttattgtg  agatcagag  gtctggaaa  ccctggaag  gcggctgga  gtatcagtc  19500
cccctgccc  ttctctggg  ctccattgc  acattcatg  aattagaaa  gctcgacct  19560
aaaactcct  ctggccggg  atgggggct  acacctgta  tcccagcac  ggcaggctg  19620
ggccagtgg  tcatttgag  tcaggagtt  aagaccagc  tggccaaca  ggtgaaacc  19680
catctccac  aaaaataca  aaatcagct  ggtggtagt  gcacgcgac  gtaatccca  19740
ctactcagg  ggctgagac  ggagaatcg  ttgagcctg  gaggtggtg  ttgtggtga  19800
ccgagattg  accactaca  tccagtctg  gcgacagtc  caaaaaaaa  aaaaagaaa  19860
gaaaaaatt  cttcttcgg  cgggcacgg  ggctcacgc  tgtaatcct  gcactttga  19920
tggccaagg  ggttggatc  cgaggtcag  agatcgaga  cattctggc  aacatggtg  19980
aaccccttc  ctactaaaa  tacaaaaaa  tagccgggc  tggtggtgg  cgcctgtag  20040
cccagctac  cgggaggct  aggcaggag  gtggcgtga  cccaggagg  gaagttgca  20100
taagccgag  ttgcgccgc  gcactccag  ctgggcgac  gcgagactc  gtctcagga  20160
aaaaaaaaa  aaaaattcc  tctttcata  tttccagag  ctcgtgcag  cagctcagt  20220
gaggcagtg  caaaagaac  tgagaccca  gccttccca  tgggctact  acacggatg  20280
agatgatga  aacactaat  gctaccatc  ttgtgtact  accatgtgc  gggcacaca  20340
acaagtact  gtgatggat  cttttcttt  cttttttta  atagagttg  ggcctcgct  20400
tgttgccca  gctggtctc  aactcctgg  ctcagtgat  ctccccacc  tggcctccc  20460
aagtgctgg  ttacaggcg  gagccgcca  acccggctg  attatttca  caactcctg  20520
ggacatttt  cacatgtcc  tgtgttgag  cagggcctc  ctcacccaa  ctggaatgc  20580
gtggcatga  cactgctca  tgcagcctc  aacttctgg  ctcaaggca  cctcctgcc  20640
cagcctccc  agtagctgg  actacaggt  cacatcacc  tgcctggct  atttttttg  20700
agagatggg  tcttgccat  ttgcccagg  ttacacatg  ccagaggct  agagaggtt  20760
agtggttgc  cacagccac  caggtggtt  agagctggg  ttcaaaccc  agtcagcct  20820
cagagctaa  actattatg  ctcagtgcg  tgtgacatt  tggaaggcc  aaggaggca  20880
ctagggggc  cctcagagg  ttccatagt  tgaactttg  agttgaacc  tgtaggatt  20940
agtccagga  tgcaccatg  ggtccctca  agacctgca  gcgggagct  ccgggagct  21000
tggggttcc  gacccagac  tcccggggg  ccacctcct  tgtctggct  ccttgactc  21060
tggcgggca  agctggctg  gcagaccaa  cgcgtggcg  cgcaggtgg  cggcggcgc  21120
caggtgcag  aggtgctca  tatcgagtg  ctgcgggac  tcctgacgc  cccgctgct  21180
tccgtgcgc  tccggtgag  caggtacgg  gcggccggt  ggcggagcc  ccggggtga  21240
gggcggggc  taatggagc  tccctttca  ctcatcagg  acggtggcg  cccccaggc  21300
ctcaccctg  agctcccag  gaccatcaa  aagttcttc  agcccaccg  gatggcggc  21360
caggatttc  tccagcgct  gaagcagct  agcctgtga  gggtgggga  ggggcggag  21420
caaagccgc  cctctgggt  ggcgggtcg  gccgtccag  tccctgact  gaaccttcc  21480
ggtccccag  cctcaacag  aggcgcaga  aatcttcaa  gccaaccac  ccatggacg  21540
agaagttac  aaggccaag  tgagagacc  cgggcgtgt  tgccggcct  tggctgctt  21600
gcttctctg  gcctctgtt  tcccatctg  aaagtgggg  caattccca  ccccaaggg  21660
tttttggga  ctgggatgc  actgtgtgg  aactaacag  tctggcaca  tctgacggc  21720
ccccccctc  tcccagctt  tggggtttg  ctctgctct  ctggacaat  tggacccca  21780
ccctgagaa  ttcgtgggg  cggggatca  ccagactaa  gccctgcag  tgggctgtc  21840
gcttcggct  gagcccaat  cccaggccc  ggtgagtgc  gctgtggga  gcctgaggc  21900
ggcaggaag  ccgcctgtc  tctctgcgt  cacccttcc  gcctcactg  tctttaatt  21960
acgtcccca  tttgaccct  ctcctctca  atttctttg  ccactttta  tcctcttta  22020
ctatcagtt  aatctcctg  ctccaacct  tggtgttcc  ctcctcttc  tgtccctcc  22080
tgatttcta  ctttccata  cctttccac  tttctctca  cttttataa  tttcttcct  22140
tctggcgcc  ctgttgatt  cagtcttac  tttttctct  ctgtgtctt  tatcacctt  22200
ctggcccct  tatccttcc  tccttctat  tcccttggg  cccgacttc  ctgggctcc  22260
catctcctc  gagttctgc  cccaatgcc  ccacccaga  gtaccggct  accctgcgc  22320
ccagcaagg  gcccgtctc  cgtcacctg  gtgagctgc  ggcacagca  ttctgagcc  22380
tggactctg  cccggggga  gtggccggc  ctgggcagc  ccttggact  aggcagttt  22440
ggtggatgg  ggacctcca  tggtgacag  gaagacacc  gggtttggg  gatgcctgg  22500
actttcctc  ggccttttg  atttttatt  ttgttcatc  gctgctgtt  acattctgg  22560
gggttaggg  gagtccccc  ccctccctt  cccccccaa  cacagaggg  agaggggcc  22620
gggaagtgg  tgtctcctc  cctcccacc  caccctgtt  tagcccctc  taccccctc  22680
ccatccagg  gctgtgtat  attgtgagc  aataaacag  gagacgcta  cagccccat  22740
tctgtgtcc  tcacccact  ctaggtagt  aaagaagtg  ggtgagggc  tgcagagtg  22800
gggtggcca  gcttcgcag  ccatgggtg  gactctggg  agacagcag  agcagcagc  22860
gccgaagcc  cagctgcaa  gccaccaga  gcactcctg  gcctggttc  tcagtcccc  22920
acaccaggt  gcaagctct  ggcagctgg  cctggtaga  ctcatcttc  gtcttctct  22980
gtggccctg  ctctggaga  agaacaggg  gcactgaca  gacaagtag  atgctaacc  23040
ttgcaagcc  caccacatc  tgatcccaa  ttctgaacg  gtggggtct  tgaacacag  23100
ttttgggag  ctcctgcca  gggagggcc  cggggctct  gctggctgt  agcaacttg  23160
agaccacaa  gatgtcact  agctcaccc  cttcctctt  ctcagcctt  gcccccatt  23220
tcctggaga  actgtgcag  tgcaggtga  cctcttagc  atacacatg  cgaacacgg  23280
agcaacaca  gagctcctg  agccttttc  aggagccca  ccgccccac  gtacaaggc  23340
ggtggaggg  aacaggcag  ggccagtgg  aggtggagt  gcacagcta  gaaggggtg  23400
agcccccga  ttggagctc  tgaccactg  gctgcattc  tccgggctt  actggggtc  23460
cagcgccat  ccaggtccc  ttctttgtc  ttctgggcc  ttaagggtt  tacgacaat  23520
tttccgttc  aacccagaa  cttgtgaaa  cctcctcca  accctcagc  tatcagcaa  23580
gcctgtgct  ttggcagtt  tgcagagcg  tggactgtg  ggatatggg  gcaagatcc  23640
ctgtgttca  atatggctc  gccactcat  agctgagcc  cagtttcct  atctgtaat  23700
tgggaatga  gaggtaatg  gatagtcct  acctgtgag  atgaagtga  ttcattctt  23760
cattacgtg  aaaggcact  ggaagaggt  aggtctcag  gttaactat  gttgactat  23820
atccaggag  ttctgaagc  aggcgggga  ctcccttcc  ctcccttcc  atctgcatc  23880
atgctcaga  ctcaaggaa  accactgcc  tatggccca  tgcatactg  gttcctccg  23940
atcctccaa  cccacctcc  actcccatt  tgtgcgacc  gggactcag  gtccccgcc  24000
gcgcagtgg  agcactgtg  cttccgctg  cctggtggg  agtgcgtgg  ggtgaccag  24060
gtatagaag  ttcggagga  gcgccggcg  tgttctggt  aaggctctg  tgggaggaa  24120
aggcggtga  gcagagcgc  tccccggcc  acgcccctc  tacccctgc  cctgcccct  24180
tcctcagtc  cctttatcc  ccaagggct  cacggtgaa  aggcagcgc  tcagttcca  24240
gtggaggag  agcagcctg  gggaaaggg  agggaatgt  atggctggg  aagaggaca  24300
gacccccga  ccactccct  catccgagc  ctacccgag  atgtctgtg  gaaggggga  24360
gccactggg  agcgcccgg  gtcccaacg  cagacaggc  cgcaacggg  ccagcagtg  24420
ctgccacca  cgctccaga  gctgcaggg  gcgtggtca  tgtgaggtc  tcatgggaa  24480
gcggggccg  cgggggagg  cggggggtg  acaaggata  gggcgtggt  aatcgggag  24540
ggcggggcc  gcaagaaga  tggagggcg  agggcagaa  ggactgggg  aggggcgag  24600
cctggaaga  tagaggcag  ggcgggagc  gccgatctt  gcgggtagg  gaatgactg  24660
agcgcagtc  agaagaggc  gggctgggg  aagatgccg  tggcagggc  gggtggtgg  24720
gaagggccc  cctggtagc  ggtgtccta  gagcgaaag  gggacgtgg  gcgggttca  24780
ctgtggata  aactggctg  ggggtgggc  cggcccgca  agtagacac  gctccaggc  24840
cggcagcag  gtcagggtc  ggagccggt  tgggacctg  agcagggca  aggctgggg  24900
tcatcgcgg  ccggcccct  tccatcgca  atcccgcct  ctcgcgact  ggcccccag  24960
tcacatccc  ccgtcggtg  ccgccaccc  ctcaccgtg  ggctcccgt  cggcaggta  25020
accgggtag  cgcgagcgg  ctgcggcgg  agggacccc  ccagccagg  gagcagcac  25080
gcctcgggc  tccccagcc  ccaccaacc  tctgttgct  ccaccaccc  gccggacac  25140
accagactg  cgaaggtcg  gcccgcggc  tcagcgaac  cggagaggg  ttcctgggt  25200
cgggaggca  gaggactgg  agtcagcag  caagcgtag  gggtggcag  gacttccca  25260
atgggcagg  aatggggag  aacccacag  cagccccga  ctcgcgcag  ggccatgct  25320
ctacgtctc  ccctctctg  gcctgagtt  cttcacttt  atacgaagt  acatcccca  25380
ctcacactg  gaagtctgt  aaatctgat  aaacatcta  cctgggcgg  caaactgaa  25440
ctaataatg  aaccgcagc  gctaccgtt  atccaggcc  gttacatgc  gagtaggca  25500
cattagcaa  gtagagaag  caagtcacc  gctgagagt  acatgcctg  gaggccgcc  25560
caccaggca  gtccacaag  gcagtattt  agtagaggt  gctagagat  tgagaggca  25620
gaggaagaa  atgcactga  gttggaaac  tgttgggat  tcaggactg  gaggtagct  25680
ggtggaagt  gactgtgga  ttagcaaca  gttaggggg  gccaggtgc  acaggcctt  25740
aaacaccag  ctgaggagc  gggaccttg  cctggggga  gtggaggct  ccggagggc  25800
gtgagcagg  aaggggcag  gccagctct  gatatagta  ggttcttct  gtggccggg  25860
gtgatggct  acacctgtc  tcccagcac  atgggaggc  gaggcggga  gactgcttg  25920
gcccaggag  tcgagacca  cccgggcaa  ttaatggaa  cccatcccc  accctagtc  25980
atctcttaa  aaaaaaaat  gctgaatgt  agccgggcg  ggtggctca  gcctgtaat  26040
ccagcactt  gggaggctg  ggcgggtgg  tcacgaggt  aggcgttca  gaccagcct  26100
gccaacata  tgaaaccct  tctctacta  aaatacaaa  aattagctg  gccaggcgt  26160
gtgaccagc  cttataatc  tagctactc  ggaggttga  gcaggggaa  cgtttgaac  26220
caggaggca  aggttgcag  gagccaaga  tgcgccatt  cactccagc  cctgtgaca  26280
tgtaagact  tgtctcaaa  aaaaaaaaa  aaaaaaaat  gctgaatgt  gtggcacag  26340
gcctatagt  tcagctact  gggaggctg  gatgagagg  tcacttgaa  ccaggagtt  26400
aaggctgca  tgagctatg  ctgagccac  gtgctctag  ctggatgac  gagcaagac  26460
ctgtctcag  aaagaaaga  agatggccc  ggcgcagtg  ctcacgcct  tcatcccag  26520
actgtggga  gccaaggca  gtggatcac  tgaggtaag  agttcgaga  cagcttggc  26580
aacatggtg  aaccctgtc  ctactaaaa  tacaaaaaa  tagccgggc  tagtggtgg  26640
cgcctgtaa  cccagctgc  cgggaagct  aggcaggag  attacttga  cccgggagg  26700
gcaggctgc  gtgagccga  atggtgcca  tgtactcca  cctgggcaa  aagagtgaa  26760
ctacgtctc  aataaaaag  gagaaagaa  agaaaaaag  aaagaaaga  aaagaaaag  26820
aaaaaaaaa  agaaaaaag  ttcttctgg  accaggtgg  gataggact  gaagctgag  26880
ggataggag  aggttggga  aatggtcca  aagaaagag  atgaggact  agccagggc  26940
agcagaaca  gtgtaagag  ttccatagc  tccccagta  ctgcaagag  gacccctct  27000
gaggaatca  gcagtccac  cactgggtc  ggtccccga  gagctccga  tcccccagg  27060
agctgtcga  gaggcaata  ctggcctag  agaggaaga  gggaccagc  taggattca  27120
gtgggccca  ggtcagaca  ccaagaacc  gtgggacca  gctgcccca  gggctgctg  27180
gaactgtag  tcccaaatg  cagtgccca  gtatcctaa  ttcccaccc  catgtcctg  27240
aacctcacc  tcaagtcct  cttcagtct  tccacgttg  ggatattgg  cagttcttc  27300
agtcccaca  gaaggacct  gaagaatca  ataggagag  atgggcgag  ggctgggac  27360
tgaactcct  ggtctgaag  aagaggggg  tgggactcc  acttctggg  ctggggact  27420
gggagtcaa  attcctggg  tctggccgg  cgcggaggc  catgcctgt  attccagca  27480
tttgggagg  caaggtggg  ggatcactt  aggtcagga  tttgagacc  gcctggcca  27540
tatggtgaa  ccccgtctc  acaaaaaat  caaaaatta  ctgggcatg  tggcacgtg  27600
ctgtaatcc  agctacttg  gaagctgag  cacgagaat  gcttgaacc  gggaggcag  27660
ggttgcagt  agccgagat  aagccactg  actccagcc  gggcaacag  gcgagactc  27720
gtctcaaaa  aaaacaaac  aacaaacaa  agattcctg  gttctgagg  aggaagtgt  27780
ggtggtctg  actcctagg  ctgagggaa  aggatgctg  gatctcaga  tcctggtct  27840
gggagaaaa  aggactggt  agtctcacc  tggctccaa  caccatttg  agtagtctc  27900
ccagcctca  ctcagagat  cccacctca  atgacagaa  aatgagggt  atgctgtgg  27960
atggaagtg  gaagaatga  tcaaggcct  gggaatcag  aaggggtat  ttggagtcc  28020
cccattgat  ctagaacac  agatacatc  tctctcaga  caacctgcc  ttcttatag  28080
gaacatcag  gatcaaaga  ggtaactgg  ttgctaaag  tcccatagc  aaattaaca  28140
ctgctttta  agagctgga  ggcctccgg  gtcatcttc  acagggact  tcacccagg  28200
cctgtccct  tcccacgtt  cctcctggg  acctgtcat  gaagctttt  cacaccaca  28260
tcgtgttct  ggtcctcgc  gagctcagc  gcacctcca  attctgccc  aacatgtgg  28320
ctccattga  ggaaccgat  acagagaac  ggagctaag  aggggttag  gacatcaga  28380
aagagcacc  ccccatccc  ttccccctt  ggacccaag  gtgccagct  ccagcccca  28440
cctctttcc  tatgacctg  cagtgcctc  ttggggaac  aggcttatt  gtccattgc  28500
tcctcggtc  tacaaattc  acactgaaa  ttccccagc  cctactgcc  tgaagaccc  28560
gagtcaaaa  accgaaccc  cttcggttt  gatacaggc  tccaaggcc  cacctgctg  28620
cgggcgggg  cgccgccgc  actgctcct  cagaatagg  ggaccccgc  ggaggccgc  28680
aggcacagc  gatgcacag  gccgcccgt  ccctcctcc  ccatttagg  ctcccaccg  28740
ggtccctca  gtggggact  tcagtgcgg  tcttggagc  tggcggtaa  cagagtaac  28800
cggcctgtg  tccggagcc  ccagagggc  agatgggga  ctgattgga  gaggattaa  28860
ttcccgcct  cttcaccca  ctcaaacag  ccctcaaac  ctattcagg  acctccccc  28920
aacccatta  gttctcttc  gccctagcc  gaagtcacg  tacccctaa  aaagatggc  28980
gcaaattga  tttgcaaag  tttctagtt  ctccgagga  gtaaagaga  ccaagaagc  29040
ggattgaag  tgatgactg  gccaaggcg  tgcctagcc  ccatcctgt  ggctttgat  29100
atttacatt  taaacggaa  aaacagctg  gcccggatc  aagattgcg  tggtcccaa  29160
gcattgcct  gcaaccaca  tccctgtag  tttccagta  atagtagta  acaatgtgc  29220
ctactcaaa  atggcgacc  tggcggggc  ttgccaagc  accaccatt  agcctgata  29280
ccattccaa  gctgtaaac  gctgtgccc  gctcaaaga  ggcggcacg  cgaagtccg  29340
gcaccctcc  tggggcgaa  tcgagaaaa  caccatctc  cctacaacc  tcgagggtg  29400
ttgagtcca  cgatcgttg  ctagtaacc  ctaaaaaaa  ggttgtttt  gttattaga  29460
aaaagaaaa  aaggaaatc  tttattttc  agaataata  aaataatat  atttctgta  29520
tgaatttat  catgatagc  taccatgta  aatgtgaaa  atcccttcc  caatttttt  29580
cctaaaata  agtttaacg  agactattc  tacgttttc  caaagatga  caatatact  29640
acatttcca  actttcttt  ttgccatga  aaagtatgt  tatttcatc  taataatgt  29700
tttttataa  ctattttat  gatgtgaca  attgatttg  ccaattctg  attgatgta  29760
attaggttg  tgaactcct  cagactagc  aactagtgc  gggacagca  tttactgac  29820
ttttaaaat  cccttatga  tatttttat  attttacac  ggcagcatt  acttgtaat  29880
acaaaagta  ttatgattc  tttttccct  cctcttcct  cttgcagat  agcccatct  29940
tctagcata  tttttaatt  tcctacttc  taaagtaca  ctttttctc  ttttttttt  30000
tttgggaga  gggacaggg  ctcgttctg  cgcccaagg  ggagtgcag  ggaaccatc  30060
cggctaact  caacctccg  ctccaggat  caagcgatt  tcctgcctc  gcctcctga  30120
tagctggga  tacaggtgt  cccccacca  gtccagcta  tttttgtag  ttttgtgga  30180
acagggtgt  gccatgttg  ccaagctgg  ctcaaactc  ttggctcaa  tgatccacc  30240
acctcagcc  ctcaaagtg  tgggactac  ggcaggagc  accatgcct  gcctaggta  30300
cattttaat  ttccttctt  cctattgat  ttttttttc  tttctctgg  ttactttta  30360
cttccttac  actttatta  aatgttagt  acacaggca  aaaagaggg  gctgctcta  30420
atgaaaaga  acttgagac  taatgtcta  atatgtgtg  ggtctttgt  tggatcctg  30480
tacaaataa  ccaactgta  aaacacatt  tgagacaat  ggaacgttt  attacacac  30540
tactgttgg  tgatactaa  aagttaatt  tgttacagg  aacaatggc  tactagtaa  30600
gtaagaaag  gttcataaa  ttggaaaga  gcctgccaa  cacacagga  taaaatcat  30660
tgattgtat  gatttgaag  cttcagcag  ccaggcgcg  cggcttacg  ctgtaatcc  30720
agcactttg  gaggccaag  tgggcgggt  acctgaggt  tggagttcg  gaccagcct  30780
accaacatg  agaaacccc  gctctacta  aaatacaaa  ttagctggg  gtggtggcg  30840
atgcctgta  actcagcta  tcgggaggc  gaggcagga  aatcgcttg  acccaggag  30900
tggaggctg  cgtgagccg  gactgtgcc  ttgcactgc  gcctgggca  caagaacaa  30960
actccatct  aaaaaaaaa  aaaaaaaaa  agcttcagc  aatgagact  tctcaaaaa  31020
aaaagggct  ccgcaggct  actgcctat  atccgggca  tctaggagg  caaaacggg  31080
ggatcacct  aggtcagga  tttgagacc  gcctggcca  catggtaaa  ccctgtctc  31140
aacaaaaat  caaaaattt  cctgcgagg  ggcacacac  tgtagtccc  gctactggg  31200
aggcagagg  aggagaatc  gtggaacca  ggaggcaga  gctgcagcg  gccgacact  31260
cgccactgc  ctccagtct  ggcgacaga  cgagatttt  tcaaaaaaa  aataataaa  31320
taaaaaaaa  taaaaataa  aataaaaga  aaaagaaaa  tagaaaccc  ataaaaaat  31380
attttaaat  ataaaggta  aaaccttta  cattaggct  tctgtaagt  cttttcaat  31440
ggtgattat  attattatt  ttacttttt  ttttttgag  cagcgcctc  ctccgtccc  31500
caggctgga  tgcagtggc  cgatctctg  tcactgcaa  ctccgcctt  cgggttcac  31560
ccattctcc  gcctcagcc  ccggagtag  tgggactac  ggcgcccgc  accacgccc  31620
gctaatttt  ttttttttt  ttttggatt  tcagtagag  cggggtttc  ccgtgttag  31680
aaggatggt  tcgatctcc  gacctcgtg  tctgcccgc  ttggcctcc  aaagtgc  31737



<210> 9554
<211> 977
<212> PRT
<213> Homo sapiens
<308> AAD15564
<400> 9554

Met Pro Ala Val Ser Lys Gly Asp Gly Met Arg Gly Leu Ala Val Phe 
  1               5                  10                  15
Ile Ser Asp Ile Arg Asn Cys Lys Ser Lys Glu Ala Glu Ile Lys Arg 
             20                  25                  30
Ile Asn Lys Glu Leu Ala Asn Ile Arg Ser Lys Phe Lys Gly Asp Lys 
         35                  40                  45
Ala Leu Asp Gly Tyr Ser Lys Lys Lys Tyr Val Cys Lys Leu Leu Phe 
     50                  55                  60
Ile Phe Leu Leu Gly His Asp Ile Asp Phe Gly His Met Glu Ala Val 
 65                  70                  75                  80
Asn Leu Leu Ser Ser Asn Lys Tyr Thr Glu Lys Gln Ile Gly Tyr Leu 
                 85                  90                  95
Phe Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu Ile Arg Leu Ile 
             100                105                110
Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn Pro Thr Phe Met 
         115                120                125
Cys Leu Ala Leu His Cys Ile Ala Asn Val Gly Ser Arg Glu Met Gly 
     130                135                140
Glu Ala Phe Ala Ala Asp Ile Pro Arg Ile Leu Val Ala Gly Asp Ser 
 145                150                155                160
Met Asp Ser Val Lys Gln Ser Ala Ala Leu Cys Leu Leu Arg Leu Tyr 
                 165                170                175
Lys Ala Ser Pro Asp Leu Val Pro Met Gly Glu Trp Thr Ala Arg Val 
             180                185                190
Val His Leu Leu Asn Asp Gln His Met Gly Val Val Thr Ala Ala Val 
         195                200                205
Ser Leu Ile Thr Cys Leu Cys Lys Lys Asn Pro Asp Asp Phe Lys Thr 
     210                215                220
Cys Val Ser Leu Ala Val Ser Arg Leu Ser Arg Ile Val Ser Ser Ala 
 225                230                235                240
Ser Thr Asp Leu Gln Asp Tyr Thr Tyr Tyr Phe Val Pro Ala Pro Trp 
                 245                250                255
Leu Ser Val Lys Leu Leu Arg Leu Leu Gln Cys Tyr Pro Pro Pro Glu 
             260                265                270
Asp Ala Ala Val Lys Gly Arg Leu Val Glu Cys Leu Glu Thr Val Leu 
         275                280                285
Asn Lys Ala Gln Glu Pro Pro Lys Ser Lys Lys Val Gln His Ser Asn 
     290                295                300
Ala Lys Asn Ala Ile Leu Phe Glu Thr Ile Ser Leu Ile Ile His Tyr 
 305                310                315                320
Asp Ser Glu Pro Asn Leu Leu Val Arg Ala Cys Asn Gln Leu Gly Gln 
                 325                330                335
Phe Leu Gln His Arg Glu Thr Asn Leu Arg Tyr Leu Ala Leu Glu Ser 
             340                345                350
Met Cys Thr Leu Ala Ser Ser Glu Phe Ser His Glu Ala Val Lys Thr 
         355                360                365
His Ile Asp Thr Val Ile Asn Ala Leu Lys Thr Glu Arg Asp Val Ser 
     370                375                380
Val Arg Gln Arg Ala Ala Asp Leu Leu Tyr Ala Met Cys Asp Arg Ser 
 385                390                395                400
Asn Ala Lys Gln Ile Val Ser Glu Met Leu Arg Tyr Leu Glu Thr Ala 
                 405                410                415
Asp Tyr Ala Ile Arg Glu Glu Ile Val Leu Lys Val Ala Ile Leu Ala 
             420                425                430
Glu Lys Tyr Ala Val Asp Tyr Ser Trp Tyr Val Asp Thr Ile Leu Asn 
         435                440                445
Leu Ile Arg Ile Ala Gly Asp Tyr Val Ser Glu Glu Val Trp Tyr Arg 
     450                455                460
Val Leu Gln Ile Val Thr Asn Arg Asp Asp Val Gln Gly Tyr Ala Ala 
 465                470                475                480
Lys Thr Val Phe Glu Ala Leu Gln Ala Pro Ala Cys His Glu Asn Met 
                 485                490                495
Val Lys Val Gly Gly Tyr Ile Leu Gly Glu Phe Gly Asn Leu Ile Ala 
             500                505                510
Gly Asp Pro Arg Ser Ser Pro Pro Val Gln Phe Ser Leu Leu His Ser 
         515                520                525
Lys Phe His Leu Cys Ser Val Ala Thr Arg Ala Leu Leu Leu Ser Thr 
     530                535                540
Tyr Ile Lys Phe Ile Asn Leu Phe Pro Glu Thr Lys Ala Thr Ile Gln 
 545                550                555                560
Gly Val Leu Arg Ala Gly Ser Gln Leu Arg Asn Ala Asp Val Glu Leu 
                 565                570                575
Gln Gln Arg Ala Val Glu Tyr Leu Thr Leu Ser Ser Val Ala Ser Thr 
             580                585                590
Asp Val Leu Ala Thr Val Leu Glu Glu Met Pro Pro Phe Pro Glu Arg 
         595                600                605
Glu Ser Ser Ile Leu Ala Lys Leu Lys Arg Lys Lys Gly Pro Gly Ala 
     610                615                620
Gly Ser Ala Leu Asp Asp Gly Arg Arg Asp Pro Ser Ser Asn Asp Ile 
 625                630                635                640
Asn Gly Gly Met Glu Pro Thr Pro Ser Thr Val Ser Thr Pro Ser Pro 
                 645                650                655
Ser Ala Asp Leu Leu Gly Leu Arg Ala Ala Pro Pro Pro Ala Ala Pro 
             660                665                670
Pro Ala Ser Ala Gly Ala Gly Asn Leu Leu Val Asp Val Phe Asp Gly 
         675                680                685
Pro Ala Ala Gln Pro Ser Leu Gly Pro Thr Pro Glu Glu Ala Phe Leu 
     690                695                700
Ser Glu Leu Glu Pro Pro Ala Pro Glu Ser Pro Met Ala Leu Leu Ala 
 705                710                715                720
Asp Pro Ala Pro Ala Ala Asp Pro Gly Pro Glu Asp Ile Gly Pro Pro 
                 725                730                735
Ile Pro Glu Ala Asp Glu Leu Leu Asn Lys Phe Val Cys Lys Asn Asn 
             740                745                750
Gly Val Leu Phe Glu Asn Gln Leu Leu Gln Ile Gly Val Lys Ser Glu 
         755                760                765
Phe Arg Gln Asn Leu Gly Arg Met Tyr Leu Phe Tyr Gly Asn Lys Thr 
     770                775                780
Ser Val Gln Phe Gln Asn Phe Ser Pro Thr Val Val His Pro Gly Asp 
 785                790                795                800
Leu Gln Thr His Leu Ala Val Gln Thr Lys Arg Val Ala Ala Gln Val 
                 805                810                815
Asp Gly Gly Ala Gln Val Gln Gln Val Leu Asn Ile Glu Cys Leu Arg 
             820                825                830
Asp Phe Leu Thr Pro Pro Leu Leu Ser Val Arg Phe Arg Tyr Gly Gly 
         835                840                845
Ala Pro Gln Ala Leu Thr Leu Lys Leu Pro Val Thr Ile Asn Lys Phe 
     850                855                860
Phe Gln Pro Thr Glu Met Ala Ala Gln Asp Phe Phe Gln Arg Trp Lys 
 865                870                875                880
Gln Leu Ser Leu Pro Gln Gln Glu Ala Gln Lys Ile Phe Lys Ala Asn 
                 885                890                895
His Pro Met Asp Ala Glu Val Thr Lys Ala Lys Leu Leu Gly Phe Gly 
             900                905                910
Ser Ala Leu Leu Asp Asn Val Asp Pro Asn Pro Glu Asn Phe Val Gly 
         915                920                925
Ala Gly Ile Ile Gln Thr Lys Ala Leu Gln Val Gly Cys Leu Leu Arg 
     930                935                940
Leu Glu Pro Asn Ala Gln Ala Gln Met Tyr Arg Leu Thr Leu Arg Thr 
 945                950                955                960
Ser Lys Glu Pro Val Ser Arg His Leu Cys Glu Leu Leu Ala Gln Gln 
                 965                970                975
Phe 
             980



<210> 9555
<211> 1481
<212> DNA
<213> Rattus norvegicus
<308> X53944
<400> 9555

ctctgaaga  cctgattta  cccacattg  tgtctgtct  ttcctagga  cattttgga  60
tcgcgttcc  ctgtgtggg  catggcacc  ctgagccag  taagcaccc  cctcaactc  120
acctgcggg  cagaaaact  cactggcgt  aaccgggcc  gtccgcacg  ctactacgc  180
ctgtcctac  gtgctctca  cctagccat  atctttggc  acggcctgg  atgtgctgc  240
gtgctgagg  agcgtgccc  gcagaccac  accaactac  tagtggtga  cctggctgt  300
gccgacctg  tagtggcca  gttggtgat  ccgtgggtg  tgtacttgg  ggtgacagg  360
ggagtctgg  atttcagcc  catttgctg  gacgttttt  tcaccctgg  tgtcatgat  420
tgtacagcc  gcatcctga  cctctgtgc  atcagcata  acaggtaca  agcggtggt  480
atgccagtt  actatcagc  cggcaccgg  cagagctcc  gtagacgtg  ggcactcat  540
atcacagct  tgtgggtgc  ggcttttgc  gtgtcctgc  ctctcctct  tggtttcaa  600
acaacaggg  atcccagca  ctgctccat  tccaaccct  attttgtca  ttactcttc  660
gtggtgtcc  tctacgttc  cttcggggt  actgtcctg  tctatgcca  gatctacat  720
gtcctgagg  aaaggcaaa  aaaacggat  ctcactcga  agaacagcc  gtgcatcag  780
atcagacct  gctttcctc  gcagtcttc  tgtctgagg  tgcatccca  tcggcagtt  840
tcaataagg  ccaggtttc  gtcagatgc  acaggacaa  tggagcaca  agaagacaa  900
caatatccc  agaaatgcc  ggaccccct  ttgtcacac  tgcagcccc  ctcacctgg  960
cagacacat  gggggctga  gcgctacta  agcatctgc  aagacactg  cttgagaca  1020
ccaagcttg  aaggcgggg  agggatgag  cccgtggaa  ggactcgga  ctccttgag  1080
cccaccatg  cacccaagc  cagcttaga  gttcgaaaa  tcagcaacg  caggttatc  1140
acgtccctg  ggctggggc  cctgcagcc  cggggagta  cacttcgag  gaagaaggc  1200
acccagatg  tggtcattg  gcttggagc  ttcattgtc  gctggctgc  cttcttcct  1260
actcacgtt  ttaataccc  ctgtcaagc  tgccacgtg  ccccagagc  ttacagagc  1320
acaacgtgg  taggctatg  gaacagtgc  ctgaatcct  tgatctata  caccttcaa  1380
gtggagttc  gcaaagcct  cctcaagat  ctgtcctgc  gaaggagga  aagagaccg  1440
actccttta  cacttcgag  tgccaggca  tttgaaccc  g  1481



<210> 9556
<211> 446
<212> PRT
<213> Rattus norvegicus
<308> P19020
<400> 9556

Met Ala Pro Leu Ser Gln Ile Ser Thr His Leu Asn Ser Thr Cys Gly 
  1               5                  10                  15
Ala Glu Asn Ser Thr Gly Val Asn Arg Ala Arg Pro His Ala Tyr Tyr 
             20                  25                  30
Ala Leu Ser Tyr Cys Ala Leu Ile Leu Ala Ile Ile Phe Gly Asn Gly 
         35                  40                  45
Leu Val Cys Ala Ala Val Leu Arg Glu Arg Ala Leu Gln Thr Thr Thr 
     50                  55                  60
Asn Tyr Leu Val Val Ser Leu Ala Val Ala Asp Leu Leu Val Ala Thr 
 65                  70                  75                  80
Leu Val Met Pro Trp Val Val Tyr Leu Glu Val Thr Gly Gly Val Trp 
                 85                  90                  95
Asn Phe Ser Arg Ile Cys Cys Asp Val Phe Val Thr Leu Asp Val Met 
             100                105                110
Met Cys Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile Ser Ile Asp Arg 
         115                120                125
Tyr Thr Ala Val Val Met Pro Val His Tyr Gln His Gly Thr Gly Gln 
     130                135                140
Ser Ser Cys Arg Arg Val Ala Leu Met Ile Thr Ala Val Trp Val Leu 
 145                150                155                160
Ala Phe Ala Val Ser Cys Pro Leu Leu Phe Gly Phe Asn Thr Thr Gly 
                 165                170                175
Asp Pro Ser Ile Cys Ser Ile Ser Asn Pro Asp Phe Val Ile Tyr Ser 
             180                185                190
Ser Val Val Ser Phe Tyr Val Pro Phe Gly Val Thr Val Leu Val Tyr 
         195                200                205
Ala Arg Ile Tyr Ile Val Leu Arg Gln Arg Gln Arg Lys Arg Ile Leu 
     210                215                220
Thr Arg Gln Asn Ser Gln Cys Ile Ser Ile Arg Pro Gly Phe Pro Gln 
 225                230                235                240
Gln Ser Ser Cys Leu Arg Leu His Pro Ile Arg Gln Phe Ser Ile Arg 
                 245                250                255
Ala Arg Phe Leu Ser Asp Ala Thr Gly Gln Met Glu His Ile Glu Asp 
             260                265                270
Lys Gln Tyr Pro Gln Lys Cys Gln Asp Pro Leu Leu Ser His Leu Gln 
         275                280                285
Pro Pro Ser Pro Gly Gln Thr His Gly Gly Leu Lys Arg Tyr Tyr Ser 
     290                295                300
Ile Cys Gln Asp Thr Ala Leu Arg His Pro Ser Leu Glu Gly Gly Ala 
 305                310                315                320
Gly Met Ser Pro Val Glu Arg Thr Arg Asn Ser Leu Ser Pro Thr Met 
                 325                330                335
Ala Pro Lys Leu Ser Leu Glu Val Arg Lys Leu Ser Asn Gly Arg Leu 
             340                345                350
Ser Thr Ser Leu Arg Leu Gly Pro Leu Gln Pro Arg Gly Val Pro Leu 
         355                360                365
Arg Glu Lys Lys Ala Thr Gln Met Val Val Ile Val Leu Gly Ala Phe 
     370                375                380
Ile Val Cys Trp Leu Pro Phe Phe Leu Thr His Val Leu Asn Thr His 
 385                390                395                400
Cys Gln Ala Cys His Val Ser Pro Glu Leu Tyr Arg Ala Thr Thr Trp 
                 405                410                415
Leu Gly Tyr Val Asn Ser Ala Leu Asn Pro Val Ile Tyr Thr Thr Phe 
             420                425                430
Asn Val Glu Phe Arg Lys Ala Phe Leu Lys Ile Leu Ser Cys 
         435                440                445



<210> 9557
<211> 1316
<212> DNA
<213> Homo sapiens
<308> NM_033663
<400> 9557

taaagaaaa  ggatacatt  gaaagcagc  atgaaacat  cactaaggt  taataggga  60
gctggaaaa  cagcactca  gtaatttca  cttagaggc  aaaatgggt  atttctttc  120
gttcatttc  tagtttctg  gtcctgaga  aggcaaagt  tgctttgct  gggtatgtc  180
gctgtcagt  aatggctgc  ggagccgaa  tggtaaact  ctcggtctc  agaaatcag  240
agaaaattt  aggaagccc  ttggcatca  gcacctccc  ctgggctat  gcatctctg  300
gtcagctga  tagccacct  aactacacc  gtggggcag  gaactccac  ggtgccagc  360
aggcccgcc  acatgccta  tatgccctc  cctactgcg  gctcatcct  gccatcgtc  420
tcggcaatg  cctggtgtg  atggctgtg  tgaaggagc  ggccctgca  actaccacc  480
actacttag  agtgagcct  gctgtggca  acttgctgg  ggccacctt  gtgatgccc  540
gggtggtat  cctggaggt  acaggtgga  tctggaatt  cagccgcat  tgctgtgat  600
tttttgtca  cctggatgt  atgatgtgt  cagccagca  ccttaatct  tgtgccatc  660
gcatagaca  gtacactgc  gtggtcatg  ccgttcact  ccagcatgg  acgggacag  720
gctcctgtc  gcgcgtggc  ctcatgatc  cggccgtct  ggtactggc  tttgctgtg  780
cctgccctc  tctgtttgg  tttaatacc  caggggacc  cactgtctg  tccatctcc  840
accctgatt  tgtcatcta  tcttcagtg  tgtccttct  cctgccctt  ggagtgact  900
tccttgtct  tgccagaat  tatgtggtg  tgaaacaaa  gagacggaa  aggatcctc  960
ctcgacaga  cagtcagtg  aacagtgtc  ggcctggct  cccccaaca  accctctct  1020
ctgacccgg  acatctgga  ctgaagcgt  actacagca  ctgccagga  actgccttg  1080
gtggaccag  cttccaaga  agaggagga  agttgaaaa  agaggagaa  actcggaat  1140
ccctgagtg  cacttcggg  gaagaaggc  acccaaatg  tggccattg  gcttggggc  1200
ttcattgtc  gctggctgc  cttcttctt  acccatgtt  tcaataccc  ctgccagac  1260
tgccacgtg  ccccagagc  ttacagtgc  acgacatgg  tgggctacg  gaatag  1316



<210> 9558
<211> 400
<212> PRT
<213> Homo sapiens
<308> P35462
<400> 9558

Met Ala Ser Leu Ser Gln Leu Ser Ser His Leu Asn Tyr Thr Cys Gly 
  1               5                  10                  15
Ala Glu Asn Ser Thr Gly Ala Ser Gln Ala Arg Pro His Ala Tyr Tyr 
             20                  25                  30
Ala Leu Ser Tyr Cys Ala Leu Ile Leu Ala Ile Val Phe Gly Asn Gly 
         35                  40                  45
Leu Val Cys Met Ala Val Leu Lys Glu Arg Ala Leu Gln Thr Thr Thr 
     50                  55                  60
Asn Tyr Leu Val Val Ser Leu Ala Val Ala Asp Leu Leu Val Ala Thr 
 65                  70                  75                  80
Leu Val Met Pro Trp Val Val Tyr Leu Glu Val Thr Gly Gly Val Trp 
                 85                  90                  95
Asn Phe Ser Arg Ile Cys Cys Asp Val Phe Val Thr Leu Asp Val Met 
             100                105                110
Met Cys Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile Ser Ile Asp Arg 
         115                120                125
Tyr Thr Ala Val Val Met Pro Val His Tyr Gln His Gly Thr Gly Gln 
     130                135                140
Ser Ser Cys Arg Arg Val Ala Leu Met Ile Thr Ala Val Trp Val Leu 
 145                150                155                160
Ala Phe Ala Val Ser Cys Pro Leu Leu Phe Gly Phe Asn Thr Thr Gly 
                 165                170                175
Asp Pro Thr Val Cys Ser Ile Ser Asn Pro Asp Phe Val Ile Tyr Ser 
             180                185                190
Ser Val Val Ser Phe Tyr Leu Pro Phe Gly Val Thr Val Leu Val Tyr 
         195                200                205
Ala Arg Ile Tyr Val Val Leu Lys Gln Arg Arg Arg Lys Arg Ile Leu 
     210                215                220
Thr Arg Gln Asn Ser Gln Cys Asn Ser Val Arg Pro Gly Phe Pro Gln 
 225                230                235                240
Gln Thr Leu Ser Pro Asp Pro Ala His Leu Glu Leu Lys Arg Tyr Tyr 
                 245                250                255
Ser Ile Cys Gln Asp Thr Ala Leu Gly Gly Pro Gly Phe Gln Glu Arg 
             260                265                270
Gly Gly Glu Leu Lys Arg Glu Glu Lys Thr Arg Asn Ser Leu Ser Pro 
         275                280                285
Thr Ile Ala Pro Lys Leu Ser Leu Glu Val Arg Lys Leu Ser Asn Gly 
     290                295                300
Arg Leu Ser Thr Ser Leu Lys Leu Gly Pro Leu Gln Pro Arg Gly Val 
 305                310                315                320
Pro Leu Arg Glu Lys Lys Ala Thr Gln Met Val Ala Ile Val Leu Gly 
                 325                330                335
Ala Phe Ile Val Cys Trp Leu Pro Phe Phe Leu Thr His Val Leu Asn 
             340                345                350
Thr His Cys Gln Thr Cys His Val Ser Pro Glu Leu Tyr Ser Ala Thr 
         355                360                365
Thr Trp Leu Gly Tyr Val Asn Ser Ala Leu Asn Pro Val Ile Tyr Thr 
     370                375                380
Thr Phe Asn Ile Glu Phe Arg Lys Ala Phe Leu Lys Ile Leu Ser Cys 
 385                390                395                400



<210> 9559
<211> 1362
<212> DNA
<213> Rattus norvegicus
<308> X54096
<400> 9559

ggcacgagg  actgggctg  aatggggct  cctggctcc  cttggcagt  ggtgctgtt  60
ctgttgggg  tactgctcc  tcctgccac  tccttctgg  tcctcaatg  gctcttccc  120
ccgcacacc  cgcccaagg  tgaactcag  aaccacaca  ggcctgtca  cctcgtgcc  180
ggctgcatg  ggaaccggc  agaagccaa  ctggataaa  caaatgtgg  aaactggct  240
tgctaccga  agacagagg  cttttttac  atctggctg  atttcaaca  gtttctacc  300
ctcggggtg  actgctgga  tgataacac  agggttgtc  acaaccgaa  ctctgggca  360
atgtccaat  cccctggtg  acagatccg  gtccctggc  ttggcaaga  ctactctgt  420
gaatacttg  atgacaaca  gctagcagg  tacctgaac  cactggtgc  gaatctggt  480
aacaatggg  atgtgcggg  tgagacagt  cgggccgca  cctatgact  gcgtctggc  540
ccccgccag  aggatgaat  ctaccagaa  ctggcagga  tggtagagg  gatgtatgc  600
gcttacggg  agcctgttt  ccttattgg  cacagcctt  gctgcctac  tgtgctcca  660
ttcttactg  gtcagccac  gtcctggaa  gaccacttc  ttgatggct  catctctct  720
ggggcccca  ggggcggtt  catcaagcc  atgcggatc  tggcctcag  tgacaacca  780
ggcatcccg  tcatgtcca  cataaagct  agagaagaa  agcgcataa  cacaacttc  840
ccctggatg  ttccagctc  ccacgtgtg  cctgaagac  acgtgttca  ttccacacc  900
aacttcaac  acacaggcc  agacttcga  cgttttttt  cagatcttc  ttttgaaga  960
ggctggcac  tgtttctac  gtctcgtga  ctactagca  gcctcccag  gcctggtgt  1020
gaagtatat  gtctatacg  tgtaggcat  cccacagcc  acacctaca  ctatgacca  1080
aactttccc  acaaagacc  ggtggctgc  ctctatgaa  atggggacg  cactgtagc  1140
acacgtagc  ctgagctct  tggccaggt  cagggccgc  agtcacagg  tgtacactt  1200
ctccgcatg  atgggacag  tcatctcaa  atggtcttc  gcaataaga  actggagca  1260
attaatgct  tcctactgg  tgcctaccc  catggcact  ctaagtccc  aaccgccag  1320
ctaggtccc  caccaacgg  ataaagact  actgttatg  aa  1362



<210> 9560
<211> 440
<212> PRT
<213> Rattus norvegicus
<308> P18424
<400> 9560

Met Gly Leu Pro Gly Ser Pro Trp Gln Trp Val Leu Leu Leu Leu Gly 
  1               5                  10                  15
Leu Leu Leu Pro Pro Ala Thr Ser Phe Trp Leu Leu Asn Val Leu Phe 
             20                  25                  30
Pro Pro His Thr Thr Pro Lys Ala Glu Leu Ser Asn His Thr Arg Pro 
         35                  40                  45
Val Ile Leu Val Pro Gly Cys Met Gly Asn Arg Leu Glu Ala Lys Leu 
     50                  55                  60
Asp Lys Pro Asn Val Val Asn Trp Leu Cys Tyr Arg Lys Thr Glu Asp 
 65                  70                  75                  80
Phe Phe Thr Ile Trp Leu Asp Phe Asn Met Phe Leu Pro Leu Gly Val 
                 85                  90                  95
Asp Cys Trp Ile Asp Asn Thr Arg Val Val Tyr Asn Arg Ser Ser Gly 
             100                105                110
His Met Ser Asn Ala Pro Gly Val Gln Ile Arg Val Pro Gly Phe Gly 
         115                120                125
Lys Thr Tyr Ser Val Glu Tyr Leu Asp Asp Asn Lys Leu Ala Gly Tyr 
     130                135                140
Leu Asn Thr Leu Val Gln Asn Leu Val Asn Asn Gly Tyr Val Arg Asp 
 145                150                155                160
Glu Thr Val Arg Ala Ala Pro Tyr Asp Trp Arg Leu Ala Pro Arg Gln 
                 165                170                175
Gln Asp Glu Tyr Tyr Gln Lys Leu Ala Gly Leu Val Glu Glu Met Tyr 
             180                185                190
Ala Ala Tyr Gly Lys Pro Val Phe Leu Ile Gly His Ser Leu Gly Cys 
         195                200                205
Leu His Val Leu His Phe Leu Leu Arg Gln Pro Gln Ser Trp Lys Asp 
     210                215                220
His Phe Ile Asp Gly Phe Ile Ser Leu Gly Ala Pro Trp Gly Gly Ser 
 225                230                235                240
Ile Lys Pro Met Arg Ile Leu Ala Ser Gly Asp Asn Gln Gly Ile Pro 
                 245                250                255
Ile Met Ser Asn Ile Lys Leu Arg Glu Glu Gln Arg Ile Thr Thr Thr 
             260                265                270
Ser Pro Trp Met Phe Pro Ala His His Val Trp Pro Glu Asp His Val 
         275                280                285
Phe Ile Ser Thr Pro Asn Phe Asn Tyr Thr Gly Gln Asp Phe Glu Arg 
     290                295                300
Phe Phe Ala Asp Leu His Phe Glu Glu Gly Trp His Met Phe Leu Gln 
 305                310                315                320
Ser Arg Asp Leu Leu Ala Gly Leu Pro Ala Pro Gly Val Glu Val Tyr 
                 325                330                335
Cys Leu Tyr Gly Val Gly Met Pro Thr Ala His Thr Tyr Ile Tyr Asp 
             340                345                350
His Asn Phe Pro Tyr Lys Asp Pro Val Ala Ala Leu Tyr Glu Asp Gly 
         355                360                365
Asp Asp Thr Val Ala Thr Arg Ser Thr Glu Leu Cys Gly Gln Val Gln 
     370                375                380
Gly Arg Gln Ser Gln Gly Val His Leu Leu Arg Met Asn Gly Thr Asp 
 385                390                395                400
His Leu Asn Met Val Phe Ser Asn Lys Thr Leu Glu His Ile Asn Ala 
                 405                410                415
Ile Leu Leu Gly Ala Tyr Pro His Gly Thr Pro Lys Ser Pro Thr Ala 
             420                425                430
Ser Leu Gly Pro Pro Pro Thr Glu 
         435                440



<210> 9561
<211> 1744
<212> DNA
<213> Homo sapiens
<308> M12625
<400> 9561

tgaggcctg  ctttttcaa  aaaacattg  gtagttctg  gcctcctgc  gccccggct  60
tgtttcccc  ggcgccaag  gaagaaggc  gaactgaac  caggcccag  gccggctcc  120
tgaggctgt  cccctttcc  gcaatctct  gccacaacc  ccactggcc  ggccgtccc  180
cccactggc  ctagggccc  tcccactcc  acaccagat  aggacagcc  agtgccgct  240
tctctggca  taggcacca  ggctggaat  gggccgccc  gctccccat  gcagtgggt  300
acgctgctg  tggggctgc  gctccctcc  gccgccccc  tctggctcc  caatgtgct  360
ttccccccg  acaccacgc  caaggctga  ctcagtaac  acacacggc  cgtcatcct  420
gtgcccggc  gcctgggga  tcagctaga  gccaagctg  acaaaccag  tgtggtgaa  480
tggatgtgc  accgcaaga  agaggactt  ttcaccatc  ggctggatc  caacatgtt  540
ctacccctt  gggtagact  ctggatcga  aacaccagg  ttgtctaca  ccggagctc  600
gggctcgtg  ccaacgccc  tggtgtcca  atccgcgtc  ctggctttg  caagaccta  660
tctgtggag  acctggaca  cagcaagct  gcagggtac  tgcacacac  ggtgcagaa  720
ctggtcaac  atggctacg  gcgggacga  actgtgcgc  ccgccccct  tgactggcg  780
ctggagccc  gccagcagg  ggagtacta  cgcaagctc  cagggctgg  ggaggagat  840
cacgctgcc  atgggaagc  tgtcttcct  attggccac  gcctcggct  tctacactt  900
ctctatttc  tgctgcgcc  gccccaggc  tggaaggac  gctttattg  tggcttcat  960
tctcttggg  ctccctggg  tggctccat  aagcccatg  tggtcttgg  ctcaggtga  1020
aaccagggc  tccccatca  gtccagcat  aagctgaaa  aggagcagc  cataaccac  1080
acctccccc  ggatgtttc  ctctcgcat  gcgtggcct  aggaccacg  gttcatttc  1140
acacccagc  tcaactaca  aggccgtga  ttccaacgc  tctttgcag  cctgcactt  1200
gaggaaggc  ggtacatgt  gctgcagtc  cgtgacctc  tggcaggac  cccagcacc  1260
ggtgtggaa  tatactgtc  ttacggcgt  ggcctgccc  cgccccgca  ctacatcta  1320
gaccacggc  tcccctaca  ggaccctgt  ggtgtgctc  atgaggatg  tgatgacac  1380
gtggcgacc  gcagcaccg  gctctgtgg  ctgtggcag  gccgccagc  acagcctgt  1440
cacctgctg  ccctgcacg  gatacagca  ctcaacatg  tcttcagca  cctgaccct  1500
gagcacatc  atgccatcc  gctgggtgc  taccgccag  gtccccctg  atccccgac  1560
gccagccca  agcccccgc  tcctgaata  agaccttcc  ttgctaccg  aagccctga  1620
ggctatgtt  caggttgaa  ggaggcact  gagtcccac  ctaggtttc  ctcctcacc  1680
gccacaggc  cagtgctgt  tgcagtgag  caagatggg  tctgctgag  cctgggact  1740
agct  1744



<210> 9562
<211> 440
<212> PRT
<213> Homo sapiens
<308> P04180
<400> 9562

Met Gly Pro Pro Gly Ser Pro Trp Gln Trp Val Thr Leu Leu Leu Gly 
  1               5                  10                  15
Leu Leu Leu Pro Pro Ala Ala Pro Phe Trp Leu Leu Asn Val Leu Phe 
             20                  25                  30
Pro Pro His Thr Thr Pro Lys Ala Glu Leu Ser Asn His Thr Arg Pro 
         35                  40                  45
Val Ile Leu Val Pro Gly Cys Leu Gly Asn Gln Leu Glu Ala Lys Leu 
     50                  55                  60
Asp Lys Pro Asp Val Val Asn Trp Met Cys Tyr Arg Lys Thr Glu Asp 
 65                  70                  75                  80
Phe Phe Thr Ile Trp Leu Asp Leu Asn Met Phe Leu Pro Leu Gly Val 
                 85                  90                  95
Asp Cys Trp Ile Asp Asn Thr Arg Val Val Tyr Asn Arg Ser Ser Gly 
             100                105                110
Leu Val Ser Asn Ala Pro Gly Val Gln Ile Arg Val Pro Gly Phe Gly 
         115                120                125
Lys Thr Tyr Ser Val Glu Tyr Leu Asp Ser Ser Lys Leu Ala Gly Tyr 
     130                135                140
Leu His Thr Leu Val Gln Asn Leu Val Asn Asn Gly Tyr Val Arg Asp 
 145                150                155                160
Glu Thr Val Arg Ala Ala Pro Tyr Asp Trp Arg Leu Glu Pro Gly Gln 
                 165                170                175
Gln Glu Glu Tyr Tyr Arg Lys Leu Ala Gly Leu Val Glu Glu Met His 
             180                185                190
Ala Ala Tyr Gly Lys Pro Val Phe Leu Ile Gly His Ser Leu Gly Cys 
         195                200                205
Leu His Leu Leu Tyr Phe Leu Leu Arg Gln Pro Gln Ala Trp Lys Asp 
     210                215                220
Arg Phe Ile Asp Gly Phe Ile Ser Leu Gly Ala Pro Trp Gly Gly Ser 
 225                230                235                240
Ile Lys Pro Met Leu Val Leu Ala Ser Gly Asp Asn Gln Gly Ile Pro 
                 245                250                255
Ile Met Ser Ser Ile Lys Leu Lys Glu Glu Gln Arg Ile Thr Thr Thr 
             260                265                270
Ser Pro Trp Met Phe Pro Ser Arg Met Ala Trp Pro Glu Asp His Val 
         275                280                285
Phe Ile Ser Thr Pro Ser Phe Asn Tyr Thr Gly Arg Asp Phe Gln Arg 
     290                295                300
Phe Phe Ala Asp Leu His Phe Glu Glu Gly Trp Tyr Met Trp Leu Gln 
 305                310                315                320
Ser Arg Asp Leu Leu Ala Gly Leu Pro Ala Pro Gly Val Glu Val Tyr 
                 325                330                335
Cys Leu Tyr Gly Val Gly Leu Pro Thr Pro Arg Thr Tyr Ile Tyr Asp 
             340                345                350
His Gly Phe Pro Tyr Thr Asp Pro Val Gly Val Leu Tyr Glu Asp Gly 
         355                360                365
Asp Asp Thr Val Ala Thr Arg Ser Thr Glu Leu Cys Gly Leu Trp Gln 
     370                375                380
Gly Arg Gln Pro Gln Pro Val His Leu Leu Pro Leu His Gly Ile Gln 
 385                390                395                400
His Leu Asn Met Val Phe Ser Asn Leu Thr Leu Glu His Ile Asn Ala 
                 405                410                415
Ile Leu Leu Gly Ala Tyr Arg Gln Gly Pro Pro Ala Ser Pro Thr Ala 
             420                425                430
Ser Pro Glu Pro Pro Pro Pro Glu 
         435                440



<210> 9563
<211> 2871
<212> DNA
<213> Rattus norvegicus
<308> X54249
<400> 9563

gaattccga  aaaggaaat  agggggaaa  gtcttaaag  aaagaggga  aggagagat  60
cacggagat  aagatcttg  atccaaaca  accgagcca  tccgaatta  gatctttga  120
ggggggtac  aatccaatg  agattatgt  tatgtcaga  gacgtggac  gggaaagta  180
atttgtgaa  agtgtggaa  tcgctgtaa  aagccaagc  tgctgaaaa  acatatacg  240
actcatact  atgttcggc  ttatgtatg  aagttatgt  attttgcct  caagacgaa  300
ggaaaccta  cgaaacaca  gaaatctaa  gcccacatg  aaaagtgtc  ggagctggg  360
gtctcgatg  catcagtag  tgagacaga  acagaagaa  cagaaaata  ggaagattt  420
cacaaaaca  ctgagaagc  cagcatgtc  ggcatttca  ctgaccacc  gttctcaga  480
gctgaggaa  ctgacggag  ggatggaga  gataatgat  aagatgatg  agacgatga  540
gactttgat  accaaggag  tttgacacc  aaaacaagg  caagaagca  cagtcctca  600
cctcctcgg  tctcctcct  gcctgtcaa  gttggcgct  tagcccacg  cgtcccctc  660
gatagctct  tgggacatt  gtcattgat  agctatttg  ttactctac  cagtattca  720
gtcactcag  tcatgacac  cagtgactc  tgtgaagac  cccagatga  agaatatca  780
aggctgttc  agagcaaaa  cacagactc  gaacccgac  aagacaggt  agacatccc  840
agctccatg  acgaagagg  catgttgtc  tcagagcca  gctcctccc  aagggactt  900
tccccctca  gctaccggt  ctcaccagg  tatgattct  caccctgtc  agataattc  960
ccaaagagg  atctgatac  caaaggaga  ttgtcaccc  gaagacatt  atcacctag  1020
agagatcta  cacccatga  gcatctgtc  ccaagaaaa  aagctgcat  gaggagaga  1080
atgtcccaa  gggatgctt  accaaggag  catttgtcc  cacggagac  attgtctcc  1140
ggaaaagac  ttacaacaa  aagggacct  tctcccaga  gagagagaa  atatatgac  1200
accattaga  caccatctc  cagaagggc  ttataccat  acccaccat  accaatggg  1260
cagtatctg  aaacagagc  aattgtatt  gggcctcct  atctaagaa  aggattacc  1320
caggttcct  acttcagtc  ctatggaga  caagaaggt  cttatgaac  tcacggctc  1380
agccttttc  ctgagggtc  tactgacta  gtcttcagt  atcttcccc  ccattctca  1440
cagcaagtg  gagctccta  ccccatggt  ccagttggt  ggatccaaa  ggttcactc  1500
ttgccgcca  ccatttccg  tttacatcc  ccacccaca  tgcctctgc  cacagaggg  1560
tctgaggag  agaaaggag  acccgggga  gccctcacc  aggatccct  caccctttc  1620
aggcggcat  agaaacaag  ccctcacgt  ttgcagtca  ctggtctac  tagttctcc  1680
tcctcccca  ggctattga  gaaacagag  acttcagaa  acagcctaa  ttccacaga  1740
agagaacag  aggaaaaca  acagacttg  acaaaagcc  tcgcctcac  ccggattgc  1800
acagaagag  cagctctgc  tggggctga  cagcccaca  gggtgcagg  gtccccgca  1860
aaacccttg  agagtgcac  catcagcat  agacacttt  gcgggcctg  gccaggtca  1920
ctctgtacc  cagccgccc  ccctgactt  cacgatggt  aaaaggaca  ttttggtac  1980
tcacagact  cagtagccc  ccccacgtt  tacagcaag  gcagtgtgg  tgagaagca  2040
gtggacttt  agagcagca  ggaattatc  ttaagcaca  aggaaggca  tgagccctc  2100
tcggaaaag  atcgactcc  ttgatctgc  atgcatgga  acattcatt  ccacatttc  2160
ccctccccc  ttttgtttt  gtttttcta  ggatagaaa  aaacgagtt  atagcatgc  2220
tgtcctaag  tacagtagt  ggctattat  aatactttt  ttattttga  gacaattag  2280
gaaattaac  agtcatctt  agcctgacc  aaacaaaat  tgaaattaa  ctattgggt  2340
tggtaactt  gaaaaaaat  gtacagatg  ttgtgcctt  tctttactt  gcttatatt  2400
ttataagca  ttttttagc  gtaatttgt  catatttta  aatttgtgt  tctgctttg  2460
aataaatgt  atctctttc  tcttttgga  acttggatc  taacgacgt  aagcaaagc  2520
gcatctata  atattgtga  gttgcacta  aacatattt  tatatgata  aactgaaca  2580
cttttatgt  cagctctca  tctgtaata  taatattta  tttgtttca  aaactgtac  2640
tttttttct  aatgttgtg  attgctttt  tatgtgaag  atgggttcc  tgttgcgta  2700
ctagaacag  aatgtccat  gtaagcaag  tatttaaac  agaatatct  attctgcac  2760
tatgcataa  ttacaaaaa  aagataaag  acgtatcag  cggttctta  cctgtaaat  2820
ctttttgtc  cttgtttgc  ggattgaca  taacttaag  gctgggaat  c  2871



<210> 9564
<211> 707
<212> PRT
<213> Rattus norvegicus
<308> CAA38150
<400> 9564

Glu Phe Arg Glu Arg Lys Leu Gly Gly Asn Val Leu Lys Glu Arg Gly 
  1               5                  10                  15
Lys Gly Glu Ile His Gly Asp Lys Asp Leu Gly Ser Lys Gln Thr Glu 
             20                  25                  30
Pro Ile Arg Ile Lys Ile Phe Glu Gly Gly Tyr Lys Ser Asn Glu Asp 
         35                  40                  45
Tyr Val Tyr Val Arg Gly Arg Gly Arg Gly Lys Tyr Ile Cys Glu Glu 
     50                  55                  60
Cys Gly Ile Arg Cys Lys Lys Pro Ser Met Leu Lys Lys His Ile Arg 
 65                  70                  75                  80
Thr His Thr Asp Val Arg Pro Tyr Val Cys Lys Leu Cys Asn Phe Ala 
                 85                  90                  95
Phe Lys Thr Lys Gly Asn Leu Thr Lys His Met Lys Ser Lys Ala His 
             100                105                110
Met Lys Lys Cys Leu Glu Leu Gly Val Ser Met Thr Ser Val Asp Glu 
         115                120                125
Thr Glu Thr Glu Glu Ala Glu Asn Met Glu Asp Leu His Lys Thr Ser 
     130                135                140
Glu Lys His Ser Met Ser Gly Ile Ser Thr Asp His Gln Phe Ser Asp 
 145                150                155                160
Ala Glu Glu Ser Asp Gly Glu Asp Gly Asp Asp Asn Asp Glu Asp Asp 
                 165                170                175
Glu Asp Asp Asp Asp Phe Asp Asp Gln Gly Asp Leu Thr Pro Lys Thr 
             180                185                190
Arg Ser Arg Ser Thr Ser Pro Gln Pro Pro Arg Phe Ser Ser Leu Pro 
         195                200                205
Val Asn Val Gly Ala Val Ala His Gly Val Pro Ser Asp Ser Ser Leu 
     210                215                220
Gly His Ser Ser Leu Ile Ser Tyr Leu Val Thr Leu Pro Ser Ile Gln 
 225                230                235                240
Val Thr Gln Leu Met Thr Pro Ser Asp Ser Cys Glu Asp Thr Gln Met 
                 245                250                255
Thr Glu Tyr Gln Arg Leu Phe Gln Ser Lys Ser Thr Asp Ser Glu Pro 
             260                265                270
Asp Lys Asp Arg Leu Asp Ile Pro Ser Ser Met Asp Glu Glu Ala Met 
         275                280                285
Leu Ser Ser Glu Pro Ser Ser Ser Pro Arg Asp Phe Ser Pro Ser Ser 
     290                295                300
Tyr Arg Ser Ser Pro Gly Tyr Asp Ser Ser Pro Cys Arg Asp Asn Ser 
 305                310                315                320
Pro Lys Arg Tyr Leu Ile Pro Lys Gly Asp Leu Ser Pro Arg Arg His 
                 325                330                335
Leu Ser Pro Arg Arg Asp Leu Ser Pro Met Arg His Leu Ser Pro Arg 
             340                345                350
Lys Glu Ala Ala Leu Arg Arg Glu Met Ser Gln Gly Asp Ala Ser Pro 
         355                360                365
Arg Arg His Leu Ser Pro Arg Arg Pro Leu Ser Pro Gly Lys Asp Ile 
     370                375                380
Thr Thr Arg Arg Asp Leu Ser Pro Arg Arg Glu Arg Arg Tyr Met Thr 
 385                390                395                400
Thr Ile Arg Ala Pro Ser Pro Arg Arg Ala Leu Tyr His Asn Pro Pro 
                 405                410                415
Leu Pro Met Gly Gln Tyr Leu Gln Thr Glu Pro Ile Val Leu Gly Pro 
             420                425                430
Pro Asn Leu Arg Arg Gly Leu Pro Gln Val Pro Tyr Phe Ser Leu Tyr 
         435                440                445
Gly Asp Gln Glu Gly Ala Tyr Glu His His Gly Ser Ser Leu Phe Pro 
     450                455                460
Glu Gly Pro Thr Asp Tyr Val Phe Ser His Leu Pro Leu His Ser Gln 
 465                470                475                480
Gln Gln Val Arg Ala Pro Ile Pro Met Val Pro Val Gly Gly Ile Gln 
                 485                490                495
Met Val His Ser Leu Pro Pro Ala Ile Ser Gly Leu His Pro Pro Pro 
             500                505                510
Thr Leu Pro Leu Pro Thr Glu Gly Ser Glu Glu Lys Lys Gly Ala Pro 
         515                520                525
Gly Glu Ala Leu Thr Gln Asp Pro Tyr Thr Leu Ser Arg Arg His Glu 
     530                535                540
Lys Gln Ala Pro His Val Leu Gln Ser Ser Gly Leu Pro Ser Ser Pro 
 545                550                555                560
Ser Ser Pro Arg Leu Leu Met Lys Gln Ser Thr Ser Glu Asp Ser Leu 
                 565                570                575
Asn Ser Thr Glu Arg Glu Gln Glu Glu Asn Ile Gln Thr Cys Thr Lys 
             580                585                590
Ala Ile Ala Ser Leu Arg Ile Ala Thr Glu Glu Ala Ala Leu Leu Gly 
         595                600                605
Ala Asp Gln Pro Thr Trp Val Gln Glu Ser Pro Gln Lys Pro Leu Glu 
     610                615                620
Ser Ala His Ile Ser Ile Arg His Phe Ser Gly Pro Glu Pro Gly Gln 
 625                630                635                640
Leu Cys Thr Ser Ala Ala His Pro Asp Leu His Asp Gly Glu Lys Asp 
                 645                650                655
Thr Phe Gly Thr Ser Gln Thr Ala Val Ala His Pro Thr Phe Tyr Ser 
             660                665                670
Lys Gly Ser Val Asp Glu Lys Gln Val Asp Phe Gln Ser Ser Lys Glu 
         675                680                685
Leu Ser Leu Ser Thr Glu Glu Gly Asn Glu Pro Ser Ser Glu Lys Asn 
     690                695                700
Arg Leu His 
 705



<210> 9565
<211> 2871
<212> DNA
<213> Rattus norvegicus
<308> X54249
<400> 9565

gaattccga  aaaggaaat  agggggaaa  gtcttaaag  aaagaggga  aggagagat  60
cacggagat  aagatcttg  atccaaaca  accgagcca  tccgaatta  gatctttga  120
ggggggtac  aatccaatg  agattatgt  tatgtcaga  gacgtggac  gggaaagta  180
atttgtgaa  agtgtggaa  tcgctgtaa  aagccaagc  tgctgaaaa  acatatacg  240
actcatact  atgttcggc  ttatgtatg  aagttatgt  attttgcct  caagacgaa  300
ggaaaccta  cgaaacaca  gaaatctaa  gcccacatg  aaaagtgtc  ggagctggg  360
gtctcgatg  catcagtag  tgagacaga  acagaagaa  cagaaaata  ggaagattt  420
cacaaaaca  ctgagaagc  cagcatgtc  ggcatttca  ctgaccacc  gttctcaga  480
gctgaggaa  ctgacggag  ggatggaga  gataatgat  aagatgatg  agacgatga  540
gactttgat  accaaggag  tttgacacc  aaaacaagg  caagaagca  cagtcctca  600
cctcctcgg  tctcctcct  gcctgtcaa  gttggcgct  tagcccacg  cgtcccctc  660
gatagctct  tgggacatt  gtcattgat  agctatttg  ttactctac  cagtattca  720
gtcactcag  tcatgacac  cagtgactc  tgtgaagac  cccagatga  agaatatca  780
aggctgttc  agagcaaaa  cacagactc  gaacccgac  aagacaggt  agacatccc  840
agctccatg  acgaagagg  catgttgtc  tcagagcca  gctcctccc  aagggactt  900
tccccctca  gctaccggt  ctcaccagg  tatgattct  caccctgtc  agataattc  960
ccaaagagg  atctgatac  caaaggaga  ttgtcaccc  gaagacatt  atcacctag  1020
agagatcta  cacccatga  gcatctgtc  ccaagaaaa  aagctgcat  gaggagaga  1080
atgtcccaa  gggatgctt  accaaggag  catttgtcc  cacggagac  attgtctcc  1140
ggaaaagac  ttacaacaa  aagggacct  tctcccaga  gagagagaa  atatatgac  1200
accattaga  caccatctc  cagaagggc  ttataccat  acccaccat  accaatggg  1260
cagtatctg  aaacagagc  aattgtatt  gggcctcct  atctaagaa  aggattacc  1320
caggttcct  acttcagtc  ctatggaga  caagaaggt  cttatgaac  tcacggctc  1380
agccttttc  ctgagggtc  tactgacta  gtcttcagt  atcttcccc  ccattctca  1440
cagcaagtg  gagctccta  ccccatggt  ccagttggt  ggatccaaa  ggttcactc  1500
ttgccgcca  ccatttccg  tttacatcc  ccacccaca  tgcctctgc  cacagaggg  1560
tctgaggag  agaaaggag  acccgggga  gccctcacc  aggatccct  caccctttc  1620
aggcggcat  agaaacaag  ccctcacgt  ttgcagtca  ctggtctac  tagttctcc  1680
tcctcccca  ggctattga  gaaacagag  acttcagaa  acagcctaa  ttccacaga  1740
agagaacag  aggaaaaca  acagacttg  acaaaagcc  tcgcctcac  ccggattgc  1800
acagaagag  cagctctgc  tggggctga  cagcccaca  gggtgcagg  gtccccgca  1860
aaacccttg  agagtgcac  catcagcat  agacacttt  gcgggcctg  gccaggtca  1920
ctctgtacc  cagccgccc  ccctgactt  cacgatggt  aaaaggaca  ttttggtac  1980
tcacagact  cagtagccc  ccccacgtt  tacagcaag  gcagtgtgg  tgagaagca  2040
gtggacttt  agagcagca  ggaattatc  ttaagcaca  aggaaggca  tgagccctc  2100
tcggaaaag  atcgactcc  ttgatctgc  atgcatgga  acattcatt  ccacatttc  2160
ccctccccc  ttttgtttt  gtttttcta  ggatagaaa  aaacgagtt  atagcatgc  2220
tgtcctaag  tacagtagt  ggctattat  aatactttt  ttattttga  gacaattag  2280
gaaattaac  agtcatctt  agcctgacc  aaacaaaat  tgaaattaa  ctattgggt  2340
tggtaactt  gaaaaaaat  gtacagatg  ttgtgcctt  tctttactt  gcttatatt  2400
ttataagca  ttttttagc  gtaatttgt  catatttta  aatttgtgt  tctgctttg  2460
aataaatgt  atctctttc  tcttttgga  acttggatc  taacgacgt  aagcaaagc  2520
gcatctata  atattgtga  gttgcacta  aacatattt  tatatgata  aactgaaca  2580
cttttatgt  cagctctca  tctgtaata  taatattta  tttgtttca  aaactgtac  2640
tttttttct  aatgttgtg  attgctttt  tatgtgaag  atgggttcc  tgttgcgta  2700
ctagaacag  aatgtccat  gtaagcaag  tatttaaac  agaatatct  attctgcac  2760
tatgcataa  ttacaaaaa  aagataaag  acgtatcag  cggttctta  cctgtaaat  2820
ctttttgtc  cttgtttgc  ggattgaca  taacttaag  gctgggaat  c  2871



<210> 9566
<211> 707
<212> PRT
<213> Rattus norvegicus
<308> CAA38150
<400> 9566

Glu Phe Arg Glu Arg Lys Leu Gly Gly Asn Val Leu Lys Glu Arg Gly 
  1               5                  10                  15
Lys Gly Glu Ile His Gly Asp Lys Asp Leu Gly Ser Lys Gln Thr Glu 
             20                  25                  30
Pro Ile Arg Ile Lys Ile Phe Glu Gly Gly Tyr Lys Ser Asn Glu Asp 
         35                  40                  45
Tyr Val Tyr Val Arg Gly Arg Gly Arg Gly Lys Tyr Ile Cys Glu Glu 
     50                  55                  60
Cys Gly Ile Arg Cys Lys Lys Pro Ser Met Leu Lys Lys His Ile Arg 
 65                  70                  75                  80
Thr His Thr Asp Val Arg Pro Tyr Val Cys Lys Leu Cys Asn Phe Ala 
                 85                  90                  95
Phe Lys Thr Lys Gly Asn Leu Thr Lys His Met Lys Ser Lys Ala His 
             100                105                110
Met Lys Lys Cys Leu Glu Leu Gly Val Ser Met Thr Ser Val Asp Glu 
         115                120                125
Thr Glu Thr Glu Glu Ala Glu Asn Met Glu Asp Leu His Lys Thr Ser 
     130                135                140
Glu Lys His Ser Met Ser Gly Ile Ser Thr Asp His Gln Phe Ser Asp 
 145                150                155                160
Ala Glu Glu Ser Asp Gly Glu Asp Gly Asp Asp Asn Asp Glu Asp Asp 
                 165                170                175
Glu Asp Asp Asp Asp Phe Asp Asp Gln Gly Asp Leu Thr Pro Lys Thr 
             180                185                190
Arg Ser Arg Ser Thr Ser Pro Gln Pro Pro Arg Phe Ser Ser Leu Pro 
         195                200                205
Val Asn Val Gly Ala Val Ala His Gly Val Pro Ser Asp Ser Ser Leu 
     210                215                220
Gly His Ser Ser Leu Ile Ser Tyr Leu Val Thr Leu Pro Ser Ile Gln 
 225                230                235                240
Val Thr Gln Leu Met Thr Pro Ser Asp Ser Cys Glu Asp Thr Gln Met 
                 245                250                255
Thr Glu Tyr Gln Arg Leu Phe Gln Ser Lys Ser Thr Asp Ser Glu Pro 
             260                265                270
Asp Lys Asp Arg Leu Asp Ile Pro Ser Ser Met Asp Glu Glu Ala Met 
         275                280                285
Leu Ser Ser Glu Pro Ser Ser Ser Pro Arg Asp Phe Ser Pro Ser Ser 
     290                295                300
Tyr Arg Ser Ser Pro Gly Tyr Asp Ser Ser Pro Cys Arg Asp Asn Ser 
 305                310                315                320
Pro Lys Arg Tyr Leu Ile Pro Lys Gly Asp Leu Ser Pro Arg Arg His 
                 325                330                335
Leu Ser Pro Arg Arg Asp Leu Ser Pro Met Arg His Leu Ser Pro Arg 
             340                345                350
Lys Glu Ala Ala Leu Arg Arg Glu Met Ser Gln Gly Asp Ala Ser Pro 
         355                360                365
Arg Arg His Leu Ser Pro Arg Arg Pro Leu Ser Pro Gly Lys Asp Ile 
     370                375                380
Thr Thr Arg Arg Asp Leu Ser Pro Arg Arg Glu Arg Arg Tyr Met Thr 
 385                390                395                400
Thr Ile Arg Ala Pro Ser Pro Arg Arg Ala Leu Tyr His Asn Pro Pro 
                 405                410                415
Leu Pro Met Gly Gln Tyr Leu Gln Thr Glu Pro Ile Val Leu Gly Pro 
             420                425                430
Pro Asn Leu Arg Arg Gly Leu Pro Gln Val Pro Tyr Phe Ser Leu Tyr 
         435                440                445
Gly Asp Gln Glu Gly Ala Tyr Glu His His Gly Ser Ser Leu Phe Pro 
     450                455                460
Glu Gly Pro Thr Asp Tyr Val Phe Ser His Leu Pro Leu His Ser Gln 
 465                470                475                480
Gln Gln Val Arg Ala Pro Ile Pro Met Val Pro Val Gly Gly Ile Gln 
                 485                490                495
Met Val His Ser Leu Pro Pro Ala Ile Ser Gly Leu His Pro Pro Pro 
             500                505                510
Thr Leu Pro Leu Pro Thr Glu Gly Ser Glu Glu Lys Lys Gly Ala Pro 
         515                520                525
Gly Glu Ala Leu Thr Gln Asp Pro Tyr Thr Leu Ser Arg Arg His Glu 
     530                535                540
Lys Gln Ala Pro His Val Leu Gln Ser Ser Gly Leu Pro Ser Ser Pro 
 545                550                555                560
Ser Ser Pro Arg Leu Leu Met Lys Gln Ser Thr Ser Glu Asp Ser Leu 
                 565                570                575
Asn Ser Thr Glu Arg Glu Gln Glu Glu Asn Ile Gln Thr Cys Thr Lys 
             580                585                590
Ala Ile Ala Ser Leu Arg Ile Ala Thr Glu Glu Ala Ala Leu Leu Gly 
         595                600                605
Ala Asp Gln Pro Thr Trp Val Gln Glu Ser Pro Gln Lys Pro Leu Glu 
     610                615                620
Ser Ala His Ile Ser Ile Arg His Phe Ser Gly Pro Glu Pro Gly Gln 
 625                630                635                640
Leu Cys Thr Ser Ala Ala His Pro Asp Leu His Asp Gly Glu Lys Asp 
                 645                650                655
Thr Phe Gly Thr Ser Gln Thr Ala Val Ala His Pro Thr Phe Tyr Ser 
             660                665                670
Lys Gly Ser Val Asp Glu Lys Gln Val Asp Phe Gln Ser Ser Lys Glu 
         675                680                685
Leu Ser Leu Ser Thr Glu Glu Gly Asn Glu Pro Ser Ser Glu Lys Asn 
     690                695                700
Arg Leu His 
 705



<210> 9567
<211> 573
<212> DNA
<213> Rattus norvegicus
<308> X54510
<400> 9567

gcttcctgt  cggtgagcg  cgaacgact  aagcggtgg  ccatagtgc  ttgcgatgg  60
gggtaggcg  gtgtaggcg  agccagggc  ggaagtaga  cggtggcgg  ggcggtgac  120
ctggcagct  gggactcag  gcaagtacc  cagactcaa  catgactgt  cagaggatc  180
tcaggctct  ctctgtcct  cggtcagca  tctctgtgc  tttgaggag  aacattggt  240
ttacagctg  ggcgtttaa  aaggaactt  atcctgtac  gaaactctt  ttggacaag  300
taagagagt  caaagcaaa  cgactggcg  ctggaggac  tgttgatac  ggcccagaa  360
atcagcaag  ggtggacag  gagcttttt  agcttaaac  aatgtatgg  aaaggagag  420
tggataagt  tcctacctt  aattttgag  atcccaaat  tgaagtcct  gacaaaccc  480
agtcctgag  aacatacaa  ccatgtggt  atttgtcat  acttagttg  acaattaat  540
taaaaaatt  aaataaaca  tcacttcac  gct  573



<210> 9568
<211> 108
<212> PRT
<213> Rattus norvegicus
<308> P21571
<400> 9568

Met Thr Val Gln Arg Ile Phe Arg Leu Ser Ser Val Leu Arg Ser Ala 
  1               5                  10                  15
Val Ser Val His Leu Arg Arg Asn Ile Gly Val Thr Ala Val Ala Phe 
             20                  25                  30
Asn Lys Glu Leu Asp Pro Val Gln Lys Leu Phe Leu Asp Lys Ile Arg 
         35                  40                  45
Glu Tyr Lys Ala Lys Arg Leu Ala Ser Gly Gly Pro Val Asp Thr Gly 
     50                  55                  60
Pro Glu Tyr Gln Gln Glu Val Asp Arg Glu Leu Phe Lys Leu Lys Gln 
 65                  70                  75                  80
Met Tyr Gly Lys Gly Glu Met Asp Lys Phe Pro Thr Phe Asn Phe Glu 
                 85                  90                  95
Asp Pro Lys Phe Glu Val Leu Asp Lys Pro Gln Ser 
             100                105



<210> 9569
<211> 1151
<212> DNA
<213> Homo sapiens
<308> BC002872
<400> 9569

ggcacgagg  ccgcccgac  gccatcgcc  ggcccggcc  cgcccgcgg  accagacca  60
gcagatcgg  agcggtgcc  agaaaaatt  ccttactag  tgacatttc  tcgcaatgt  120
cgatcgttt  gggcaaatt  ccaagggca  ggatgggaa  agcaagtac  cgactctca  180
cctgtttga  aagtataaa  gaaaatcag  agacgcgat  agatcctca  ttattccta  240
acatggctt  cagagtctt  ggaaagttg  tgcagcccg  cgcatgcca  cgcctgcaa  300
cctgccaag  ttgaagtct  aaaacaaag  aaacgaccc  aacatcgtg  tagtaccca  360
ggacgggac  ggatgggca  acaagcagg  tcagcaaga  ccaaagagt  ccagtgcga  420
ggcctctca  ccgccggag  cgctgccgc  gccgggttt  cagaaatct  tctccaatt  480
gcagaaacc  acacagtca  tcagtcagg  gaatacaaa  tcagtgcca  gtggaccaa  540
gtcatgggc  cagctgaat  gaaagccag  aggacacga  ggtggttta  ggggctcaa  600
ccgactgtt  tccttctct  ccgaggaat  tccgacgct  aaagcagct  gagggcagg  660
caaggctgg  aaagaaaag  gcgtcttag  tctgtcgta  gggccagga  caagcctcc  720
ccctcagaa  gtgacaagc  ggagggagg  cggtgggcg  cacataatt  ctgccacgt  780
tctgagcac  tccccaact  agctgggca  caggaactc  agtacggga  atggagccc  840
ctcctcggc  tgtaccagc  attctaagg  cccctctct  cgcccggct  agcctgtcc  900
aaaaggggc  tcacagttc  tgggaaatg  ataccaccc  cctacatac  atgacatgc  960
tcctgcttt  atgtgttcg  cgaagtcat  agaaaacca  ggtacagtg  aacgaggct  1020
ttttcccct  cctcagctc  gccttgaac  tcgagttcc  tttagacag  tccagatga  1080
tgaccaaga  tggaattat  gtgctagat  agtaaacat  acttttaat  agtaaaaaa  1140
aaaaaaaaa  a  1151



<210> 9570
<211> 108
<212> PRT
<213> Homo sapiens
<308> P18859
<400> 9570

Met Ile Leu Gln Arg Leu Phe Arg Phe Ser Ser Val Ile Arg Ser Ala 
  1               5                  10                  15
Val Ser Val His Leu Arg Arg Asn Ile Gly Val Thr Ala Val Ala Phe 
             20                  25                  30
Asn Lys Glu Leu Asp Pro Ile Gln Lys Leu Phe Val Asp Lys Ile Arg 
         35                  40                  45
Glu Tyr Lys Ser Lys Arg Gln Thr Ser Gly Gly Pro Val Asp Ala Ser 
     50                  55                  60
Ser Glu Tyr Gln Gln Glu Leu Glu Arg Glu Leu Phe Lys Leu Lys Gln 
 65                  70                  75                  80
Met Phe Gly Asn Ala Asp Met Asn Thr Phe Pro Thr Phe Lys Phe Glu 
                 85                  90                  95
Asp Pro Lys Phe Glu Val Ile Glu Lys Pro Gln Ala 
             100                105



<210> 9571
<211> 573
<212> DNA
<213> Rattus norvegicus
<308> X54510
<400> 9571

gcttcctgt  cggtgagcg  cgaacgact  aagcggtgg  ccatagtgc  ttgcgatgg  60
gggtaggcg  gtgtaggcg  agccagggc  ggaagtaga  cggtggcgg  ggcggtgac  120
ctggcagct  gggactcag  gcaagtacc  cagactcaa  catgactgt  cagaggatc  180
tcaggctct  ctctgtcct  cggtcagca  tctctgtgc  tttgaggag  aacattggt  240
ttacagctg  ggcgtttaa  aaggaactt  atcctgtac  gaaactctt  ttggacaag  300
taagagagt  caaagcaaa  cgactggcg  ctggaggac  tgttgatac  ggcccagaa  360
atcagcaag  ggtggacag  gagcttttt  agcttaaac  aatgtatgg  aaaggagag  420
tggataagt  tcctacctt  aattttgag  atcccaaat  tgaagtcct  gacaaaccc  480
agtcctgag  aacatacaa  ccatgtggt  atttgtcat  acttagttg  acaattaat  540
taaaaaatt  aaataaaca  tcacttcac  gct  573



<210> 9572
<211> 108
<212> PRT
<213> Rattus norvegicus
<308> P21571
<400> 9572

Met Thr Val Gln Arg Ile Phe Arg Leu Ser Ser Val Leu Arg Ser Ala 
  1               5                  10                  15
Val Ser Val His Leu Arg Arg Asn Ile Gly Val Thr Ala Val Ala Phe 
             20                  25                  30
Asn Lys Glu Leu Asp Pro Val Gln Lys Leu Phe Leu Asp Lys Ile Arg 
         35                  40                  45
Glu Tyr Lys Ala Lys Arg Leu Ala Ser Gly Gly Pro Val Asp Thr Gly 
     50                  55                  60
Pro Glu Tyr Gln Gln Glu Val Asp Arg Glu Leu Phe Lys Leu Lys Gln 
 65                  70                  75                  80
Met Tyr Gly Lys Gly Glu Met Asp Lys Phe Pro Thr Phe Asn Phe Glu 
                 85                  90                  95
Asp Pro Lys Phe Glu Val Leu Asp Lys Pro Gln Ser 
             100                105



<210> 9573
<211> 1151
<212> DNA
<213> Homo sapiens
<308> BC002872
<400> 9573

ggcacgagg  ccgcccgac  gccatcgcc  ggcccggcc  cgcccgcgg  accagacca  60
gcagatcgg  agcggtgcc  agaaaaatt  ccttactag  tgacatttc  tcgcaatgt  120
cgatcgttt  gggcaaatt  ccaagggca  ggatgggaa  agcaagtac  cgactctca  180
cctgtttga  aagtataaa  gaaaatcag  agacgcgat  agatcctca  ttattccta  240
acatggctt  cagagtctt  ggaaagttg  tgcagcccg  cgcatgcca  cgcctgcaa  300
cctgccaag  ttgaagtct  aaaacaaag  aaacgaccc  aacatcgtg  tagtaccca  360
ggacgggac  ggatgggca  acaagcagg  tcagcaaga  ccaaagagt  ccagtgcga  420
ggcctctca  ccgccggag  cgctgccgc  gccgggttt  cagaaatct  tctccaatt  480
gcagaaacc  acacagtca  tcagtcagg  gaatacaaa  tcagtgcca  gtggaccaa  540
gtcatgggc  cagctgaat  gaaagccag  aggacacga  ggtggttta  ggggctcaa  600
ccgactgtt  tccttctct  ccgaggaat  tccgacgct  aaagcagct  gagggcagg  660
caaggctgg  aaagaaaag  gcgtcttag  tctgtcgta  gggccagga  caagcctcc  720
ccctcagaa  gtgacaagc  ggagggagg  cggtgggcg  cacataatt  ctgccacgt  780
tctgagcac  tccccaact  agctgggca  caggaactc  agtacggga  atggagccc  840
ctcctcggc  tgtaccagc  attctaagg  cccctctct  cgcccggct  agcctgtcc  900
aaaaggggc  tcacagttc  tgggaaatg  ataccaccc  cctacatac  atgacatgc  960
tcctgcttt  atgtgttcg  cgaagtcat  agaaaacca  ggtacagtg  aacgaggct  1020
ttttcccct  cctcagctc  gccttgaac  tcgagttcc  tttagacag  tccagatga  1080
tgaccaaga  tggaattat  gtgctagat  agtaaacat  acttttaat  agtaaaaaa  1140
aaaaaaaaa  a  1151



<210> 9574
<211> 108
<212> PRT
<213> Homo sapiens
<308> P18859
<400> 9574

Met Ile Leu Gln Arg Leu Phe Arg Phe Ser Ser Val Ile Arg Ser Ala 
  1               5                  10                  15
Val Ser Val His Leu Arg Arg Asn Ile Gly Val Thr Ala Val Ala Phe 
             20                  25                  30
Asn Lys Glu Leu Asp Pro Ile Gln Lys Leu Phe Val Asp Lys Ile Arg 
         35                  40                  45
Glu Tyr Lys Ser Lys Arg Gln Thr Ser Gly Gly Pro Val Asp Ala Ser 
     50                  55                  60
Ser Glu Tyr Gln Gln Glu Leu Glu Arg Glu Leu Phe Lys Leu Lys Gln 
 65                  70                  75                  80
Met Phe Gly Asn Ala Asp Met Asn Thr Phe Pro Thr Phe Lys Phe Glu 
                 85                  90                  95
Asp Pro Lys Phe Glu Val Ile Glu Lys Pro Gln Ala 
             100                105



<210> 9575
<211> 573
<212> DNA
<213> Rattus norvegicus
<308> X54510
<400> 9575

gcttcctgt  cggtgagcg  cgaacgact  aagcggtgg  ccatagtgc  ttgcgatgg  60
gggtaggcg  gtgtaggcg  agccagggc  ggaagtaga  cggtggcgg  ggcggtgac  120
ctggcagct  gggactcag  gcaagtacc  cagactcaa  catgactgt  cagaggatc  180
tcaggctct  ctctgtcct  cggtcagca  tctctgtgc  tttgaggag  aacattggt  240
ttacagctg  ggcgtttaa  aaggaactt  atcctgtac  gaaactctt  ttggacaag  300
taagagagt  caaagcaaa  cgactggcg  ctggaggac  tgttgatac  ggcccagaa  360
atcagcaag  ggtggacag  gagcttttt  agcttaaac  aatgtatgg  aaaggagag  420
tggataagt  tcctacctt  aattttgag  atcccaaat  tgaagtcct  gacaaaccc  480
agtcctgag  aacatacaa  ccatgtggt  atttgtcat  acttagttg  acaattaat  540
taaaaaatt  aaataaaca  tcacttcac  gct  573



<210> 9576
<211> 108
<212> PRT
<213> Rattus norvegicus
<308> P21571
<400> 9576

Met Thr Val Gln Arg Ile Phe Arg Leu Ser Ser Val Leu Arg Ser Ala 
  1               5                  10                  15
Val Ser Val His Leu Arg Arg Asn Ile Gly Val Thr Ala Val Ala Phe 
             20                  25                  30
Asn Lys Glu Leu Asp Pro Val Gln Lys Leu Phe Leu Asp Lys Ile Arg 
         35                  40                  45
Glu Tyr Lys Ala Lys Arg Leu Ala Ser Gly Gly Pro Val Asp Thr Gly 
     50                  55                  60
Pro Glu Tyr Gln Gln Glu Val Asp Arg Glu Leu Phe Lys Leu Lys Gln 
 65                  70                  75                  80
Met Tyr Gly Lys Gly Glu Met Asp Lys Phe Pro Thr Phe Asn Phe Glu 
                 85                  90                  95
Asp Pro Lys Phe Glu Val Leu Asp Lys Pro Gln Ser 
             100                105



<210> 9577
<211> 1151
<212> DNA
<213> Homo sapiens
<308> BC002872
<400> 9577

ggcacgagg  ccgcccgac  gccatcgcc  ggcccggcc  cgcccgcgg  accagacca  60
gcagatcgg  agcggtgcc  agaaaaatt  ccttactag  tgacatttc  tcgcaatgt  120
cgatcgttt  gggcaaatt  ccaagggca  ggatgggaa  agcaagtac  cgactctca  180
cctgtttga  aagtataaa  gaaaatcag  agacgcgat  agatcctca  ttattccta  240
acatggctt  cagagtctt  ggaaagttg  tgcagcccg  cgcatgcca  cgcctgcaa  300
cctgccaag  ttgaagtct  aaaacaaag  aaacgaccc  aacatcgtg  tagtaccca  360
ggacgggac  ggatgggca  acaagcagg  tcagcaaga  ccaaagagt  ccagtgcga  420
ggcctctca  ccgccggag  cgctgccgc  gccgggttt  cagaaatct  tctccaatt  480
gcagaaacc  acacagtca  tcagtcagg  gaatacaaa  tcagtgcca  gtggaccaa  540
gtcatgggc  cagctgaat  gaaagccag  aggacacga  ggtggttta  ggggctcaa  600
ccgactgtt  tccttctct  ccgaggaat  tccgacgct  aaagcagct  gagggcagg  660
caaggctgg  aaagaaaag  gcgtcttag  tctgtcgta  gggccagga  caagcctcc  720
ccctcagaa  gtgacaagc  ggagggagg  cggtgggcg  cacataatt  ctgccacgt  780
tctgagcac  tccccaact  agctgggca  caggaactc  agtacggga  atggagccc  840
ctcctcggc  tgtaccagc  attctaagg  cccctctct  cgcccggct  agcctgtcc  900
aaaaggggc  tcacagttc  tgggaaatg  ataccaccc  cctacatac  atgacatgc  960
tcctgcttt  atgtgttcg  cgaagtcat  agaaaacca  ggtacagtg  aacgaggct  1020
ttttcccct  cctcagctc  gccttgaac  tcgagttcc  tttagacag  tccagatga  1080
tgaccaaga  tggaattat  gtgctagat  agtaaacat  acttttaat  agtaaaaaa  1140
aaaaaaaaa  a  1151



<210> 9578
<211> 108
<212> PRT
<213> Homo sapiens
<308> P18859
<400> 9578

Met Ile Leu Gln Arg Leu Phe Arg Phe Ser Ser Val Ile Arg Ser Ala 
  1               5                  10                  15
Val Ser Val His Leu Arg Arg Asn Ile Gly Val Thr Ala Val Ala Phe 
             20                  25                  30
Asn Lys Glu Leu Asp Pro Ile Gln Lys Leu Phe Val Asp Lys Ile Arg 
         35                  40                  45
Glu Tyr Lys Ser Lys Arg Gln Thr Ser Gly Gly Pro Val Asp Ala Ser 
     50                  55                  60
Ser Glu Tyr Gln Gln Glu Leu Glu Arg Glu Leu Phe Lys Leu Lys Gln 
 65                  70                  75                  80
Met Phe Gly Asn Ala Asp Met Asn Thr Phe Pro Thr Phe Lys Phe Glu 
                 85                  90                  95
Asp Pro Lys Phe Glu Val Ile Glu Lys Pro Gln Ala 
             100                105



<210> 9579
<211> 573
<212> DNA
<213> Rattus norvegicus
<308> X54510
<400> 9579

gcttcctgt  cggtgagcg  cgaacgact  aagcggtgg  ccatagtgc  ttgcgatgg  60
gggtaggcg  gtgtaggcg  agccagggc  ggaagtaga  cggtggcgg  ggcggtgac  120
ctggcagct  gggactcag  gcaagtacc  cagactcaa  catgactgt  cagaggatc  180
tcaggctct  ctctgtcct  cggtcagca  tctctgtgc  tttgaggag  aacattggt  240
ttacagctg  ggcgtttaa  aaggaactt  atcctgtac  gaaactctt  ttggacaag  300
taagagagt  caaagcaaa  cgactggcg  ctggaggac  tgttgatac  ggcccagaa  360
atcagcaag  ggtggacag  gagcttttt  agcttaaac  aatgtatgg  aaaggagag  420
tggataagt  tcctacctt  aattttgag  atcccaaat  tgaagtcct  gacaaaccc  480
agtcctgag  aacatacaa  ccatgtggt  atttgtcat  acttagttg  acaattaat  540
taaaaaatt  aaataaaca  tcacttcac  gct  573



<210> 9580
<211> 108
<212> PRT
<213> Rattus norvegicus
<308> P21571
<400> 9580

Met Thr Val Gln Arg Ile Phe Arg Leu Ser Ser Val Leu Arg Ser Ala 
  1               5                  10                  15
Val Ser Val His Leu Arg Arg Asn Ile Gly Val Thr Ala Val Ala Phe 
             20                  25                  30
Asn Lys Glu Leu Asp Pro Val Gln Lys Leu Phe Leu Asp Lys Ile Arg 
         35                  40                  45
Glu Tyr Lys Ala Lys Arg Leu Ala Ser Gly Gly Pro Val Asp Thr Gly 
     50                  55                  60
Pro Glu Tyr Gln Gln Glu Val Asp Arg Glu Leu Phe Lys Leu Lys Gln 
 65                  70                  75                  80
Met Tyr Gly Lys Gly Glu Met Asp Lys Phe Pro Thr Phe Asn Phe Glu 
                 85                  90                  95
Asp Pro Lys Phe Glu Val Leu Asp Lys Pro Gln Ser 
             100                105



<210> 9581
<211> 1151
<212> DNA
<213> Homo sapiens
<308> BC002872
<400> 9581

ggcacgagg  ccgcccgac  gccatcgcc  ggcccggcc  cgcccgcgg  accagacca  60
gcagatcgg  agcggtgcc  agaaaaatt  ccttactag  tgacatttc  tcgcaatgt  120
cgatcgttt  gggcaaatt  ccaagggca  ggatgggaa  agcaagtac  cgactctca  180
cctgtttga  aagtataaa  gaaaatcag  agacgcgat  agatcctca  ttattccta  240
acatggctt  cagagtctt  ggaaagttg  tgcagcccg  cgcatgcca  cgcctgcaa  300
cctgccaag  ttgaagtct  aaaacaaag  aaacgaccc  aacatcgtg  tagtaccca  360
ggacgggac  ggatgggca  acaagcagg  tcagcaaga  ccaaagagt  ccagtgcga  420
ggcctctca  ccgccggag  cgctgccgc  gccgggttt  cagaaatct  tctccaatt  480
gcagaaacc  acacagtca  tcagtcagg  gaatacaaa  tcagtgcca  gtggaccaa  540
gtcatgggc  cagctgaat  gaaagccag  aggacacga  ggtggttta  ggggctcaa  600
ccgactgtt  tccttctct  ccgaggaat  tccgacgct  aaagcagct  gagggcagg  660
caaggctgg  aaagaaaag  gcgtcttag  tctgtcgta  gggccagga  caagcctcc  720
ccctcagaa  gtgacaagc  ggagggagg  cggtgggcg  cacataatt  ctgccacgt  780
tctgagcac  tccccaact  agctgggca  caggaactc  agtacggga  atggagccc  840
ctcctcggc  tgtaccagc  attctaagg  cccctctct  cgcccggct  agcctgtcc  900
aaaaggggc  tcacagttc  tgggaaatg  ataccaccc  cctacatac  atgacatgc  960
tcctgcttt  atgtgttcg  cgaagtcat  agaaaacca  ggtacagtg  aacgaggct  1020
ttttcccct  cctcagctc  gccttgaac  tcgagttcc  tttagacag  tccagatga  1080
tgaccaaga  tggaattat  gtgctagat  agtaaacat  acttttaat  agtaaaaaa  1140
aaaaaaaaa  a  1151



<210> 9582
<211> 108
<212> PRT
<213> Homo sapiens
<308> P18859
<400> 9582

Met Ile Leu Gln Arg Leu Phe Arg Phe Ser Ser Val Ile Arg Ser Ala 
  1               5                  10                  15
Val Ser Val His Leu Arg Arg Asn Ile Gly Val Thr Ala Val Ala Phe 
             20                  25                  30
Asn Lys Glu Leu Asp Pro Ile Gln Lys Leu Phe Val Asp Lys Ile Arg 
         35                  40                  45
Glu Tyr Lys Ser Lys Arg Gln Thr Ser Gly Gly Pro Val Asp Ala Ser 
     50                  55                  60
Ser Glu Tyr Gln Gln Glu Leu Glu Arg Glu Leu Phe Lys Leu Lys Gln 
 65                  70                  75                  80
Met Phe Gly Asn Ala Asp Met Asn Thr Phe Pro Thr Phe Lys Phe Glu 
                 85                  90                  95
Asp Pro Lys Phe Glu Val Ile Glu Lys Pro Gln Ala 
             100                105



<210> 9583
<211> 811
<212> DNA
<213> Rattus norvegicus
<308> X54617
<400> 9583

tccatcttc  ctccaggca  catccagga  gattacctg  gggagctgc  caccaccat  60
ggcgaccgc  tcacagatg  ggaagtgga  gagctgtac  gggaggccc  catcgacaa  120
aaggggaat  tcaactaca  cgagttcac  cgcatcctc  agcacggag  gaaagacaa  180
gatgactga  gagctgtgg  ttccagcca  atgtccctg  tgccattgg  tcctcctgg  240
gcggtcggc  gcccttgct  ttctgcctt  tgcttccct  gttttgtat  tattctcag  300
cactttggg  cacgtgtac  ttcatcatc  gactggaaa  gggactttc  gtcattgtt  360
gatgagaac  taaggtaat  taacttaca  acagtcttg  cccttgtaa  aactgcagc  420
acagagtca  tatattttt  cagagaaag  tatccactc  attttttct  aatgataat  480
aaactttct  ataaaatac  tagttgttt  gccttcttt  cctacttga  ttttagttt  540
accgagtct  tccccaagc  gggtagatg  ggtgaatga  agcctgtca  agtttgctc  600
cactcttca  ttgtgtttc  agttgtgtt  ccatcggca  tcccagttt  ctctactcc  660
agtttattc  ctctctccc  cctggaaat  aagataaag  tccttgggt  cccaagact  720
tgtcttcca  tttggaaaa  aaggcctga  ttctcgatc  ctggggtag  tcagactcc  780
cttaaacgt  tctctgcat  acttcctgc  g  811



<210> 9584
<211> 171
<212> PRT
<213> Rattus norvegicus
<308> CAA38437
<400> 9584

Ser Ser Lys Arg Ala Lys Thr Lys Thr Thr Lys Lys Arg Pro Gln Arg 
  1               5                  10                  15
Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln Glu 
             20                  25                  30
Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe Ile 
         35                  40                  45
Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Met Gly Lys Asn Pro 
     50                  55                  60
Thr Asp Glu Tyr Leu Asp Ala Met Met Asn Glu Ala Pro Gly Pro Ile 
 65                  70                  75                  80
Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly Thr 
                 85                  90                  95
Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu Glu 
             100                105                110
Ala Ile Gly Thr Ile Gln Glu Asp Tyr Leu Arg Glu Leu Leu Thr Thr 
         115                120                125
Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Leu Tyr Arg Glu 
     130                135                140
Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Ile Glu Phe Thr Arg 
 145                150                155                160
Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
                 165                170



<210> 9585
<211> 2175
<212> DNA
<213> Rattus norvegicus
<308> X54793
<400> 9585

gcagaaatg  ttcgactac  cacagtcct  cgccagatg  gaccagtgt  tcgggcact  60
gctcctcat  tcactcggg  ctatgccaa  gatgtaaaa  ttggtgcgg  tgctcgagc  120
ttaatgctt  aaggtgtag  ccttttagc  gatgctgta  ctgttacaa  ggggccaaa  180
ggaagaaca  tgattattg  acagagttg  ggaagtccc  aagtaacaa  agatggggt  240
actgttgca  agtcaattg  tttaaagga  aaatacaaa  atatcggag  taagcttgt  300
caggatgtt  ccaataaca  aaatgaaga  gctggggat  gcaccacca  tgccactgt  360
ctggcacgg  ctattgcca  ggagggctt  gagaagatc  gcaaagggg  taatccagt  420
gaaatccgg  gaggtgtga  gttggctgt  gatgctgta  ttgctgaac  taagaaaca  480
tctaaacct  tgacaaccc  tgaagaaat  gctcaggtt  ctacaattt  tgcaaacgg  540
gacaaagac  ttgggaaca  catttctga  gcaatgaag  aggttggaa  aaagggtgt  600
atcacagtg  aggatggaa  aaccctgaa  gatgagcta  aaattattg  aggcatgaa  660
tttgataga  gatatattt  cccatattt  attaacaca  caaaaggtc  aaaatgtga  720
ttccaagat  cctatgttt  gttgagtga  aagaaaatt  ctagtgttc  gtccattgt  780
cctgctctt  aaattgcca  tgctcaccg  aagcccttg  tcataattg  tgaagatgt  840
gatggagaa  ctcttagca  actggtttt  aacaggcta  aagttggtc  tcaggttgt  900
gcagtcaaa  ctccagggt  tggggacaa  aggaagaac  agcttaaag  tatggctat  960
gctactggt  gtgcggtgt  tggagaaga  ggtttgaat  taaatcttg  agatgttca  1020
gctcatgat  tagggaaag  tggagaggt  atcgtcacc  aagatgatg  catgctttt  1080
aaaggaaaa  gtgacaaag  tcacattga  aaacgtatt  aagaaatca  tgagcagct  1140
gacatcacc  ctagtgaat  tgagaagga  aagctgaac  agcgacttg  taaactctc  1200
gatggagta  ccgtgttga  ggttggagg  acaagtgat  ttgaagtga  tgagaagaa  1260
gacagagtt  cagatgctc  caatgctac  agagcagct  ttgaagaag  cattgttct  1320
ggagggggc  gtgctctac  tcggtgcat  ccagccttg  attcattaa  gcctgctaa  1380
gaagatcag  agataggta  agaaattat  aaaagagca  ttaaaattc  tgcaatgac  1440
attgctaag  atgcaggtg  tgaaggatc  ttgatagtt  aaaaaattc  gcagagttc  1500
tcagaggtt  gctatgatg  catgcttgg  gattttgtg  acatggtgg  aaagggaat  1560
attgatcca  caaaggttg  aagaactgc  ttactggat  ctgctgggg  ggcccccct  1620
ctaactaca  ccgaagctg  agtgacaga  attcctaaa  aagagaagg  ccctggaat  1680
ggtgcaatg  gtggaatgg  agggggtat  ggaggtggc  tgttctaac  cctagaata  1740
tgctttgcc  ttatcaatg  actgtggca  gaagctcaa  gcaggttcc  caccaataa  1800
ttcagagaa  tcacctgaa  aaaatgact  aagagaagg  tggctgatc  ctgtaacca  1860
cagttactg  tttcctttg  caatacata  tggtttact  ctgtcattg  ccatgccta  1920
agataattt  ttttgtatt  ttgaataaa  acatttgta  attcctgat  ctgggtgca  1980
gagccagtg  cctgctttc  acttaaatc  ctgaggcat  tctactgtt  tgttagcat  2040
aggactgta  cgctgtgtc  ccacatgag  agttcagaa  cagcctttc  gtggagggt  2100
agaatgatt  tgtacagag  agagaagta  ccaattatg  gacaacctt  gtgtaataa  2160
attttgttt  aagtt  2175



<210> 9586
<211> 573
<212> PRT
<213> Rattus norvegicus
<308> P19226
<400> 9586

Met Leu Arg Leu Pro Thr Val Leu Arg Gln Met Arg Pro Val Ser Arg 
  1               5                  10                  15
Ala Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 
             20                  25                  30
Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 
         35                  40                  45
Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 
     50                  55                  60
Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 
 65                  70                  75                  80
Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 
                 85                  90                  95
Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 
             100                105                110
Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 
         115                120                125
Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 
     130                135                140
Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 
 145                150                155                160
Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 
                 165                170                175
Asn Gly Asp Lys Asp Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 
             180                185                190
Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 
         195                200                205
Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 
     210                215                220
Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 
 225                230                235                240
Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Val Gln Ser 
                 245                250                255
Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 
             260                265                270
Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 
         275                280                285
Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 
     290                295                300
Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 
 305                310                315                320
Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Asn Leu Asn Leu Glu Asp 
                 325                330                335
Val Gln Ala His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 
             340                345                350
Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala His Ile Glu 
         355                360                365
Lys Arg Ile Gln Glu Ile Thr Glu Gln Leu Asp Ile Thr Thr Ser Glu 
     370                375                380
Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 
 385                390                395                400
Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 
                 405                410                415
Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 
             420                425                430
Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 
         435                440                445
Pro Ala Leu Asp Ser Leu Lys Pro Ala Asn Glu Asp Gln Lys Ile Gly 
     450                455                460
Ile Glu Ile Ile Lys Arg Ala Leu Lys Ile Pro Ala Met Thr Ile Ala 
 465                470                475                480
Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Leu Gln 
                 485                490                495
Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Leu Gly Asp Phe Val Asn 
             500                505                510
Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 
         515                520                525
Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Ala 
     530                535                540
Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 
 545                550                555                560
Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 
                 565                570



<210> 9587
<211> 476
<212> DNA
<213> Homo sapiens
<308> BF063615
<400> 9587

ttctttttt  aactttaaa  aaattttta  tacacaaag  ttgtcacat  attggatac  60
tctctactt  gtacacaat  attctcact  tccacagaa  ggtattttg  tgcttacag  120
gctgggtat  attgttgat  ccactcatt  ccctgttgc  ttggagagg  cttggctgt  180
tatgctgaa  ttcaaacca  tgagccttg  tgagacgct  aggccaagc  tgaagtgga  240
acactggtc  ccatagaac  agcagcagt  aaagaagag  aaagcatag  accatcttt  300
ctggtctca  tgttggggc  cctgctgag  acagaggct  tgattagtc  aaagctcaa  360
agctgttgt  tgcctttct  ctctaaccc  tcgagccct  tgtgtatag  gaaggggaa  420
aaatattct  agctttcag  aggagaatc  tagggtttg  cagattaac  tcttgt  476



<210> 9588
<211> 573
<212> PRT
<213> Homo sapiens
<308> P10809
<400> 9588

Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 
  1               5                  10                  15
Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 
             20                  25                  30
Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 
         35                  40                  45
Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 
     50                  55                  60
Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 
 65                  70                  75                  80
Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 
                 85                  90                  95
Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 
             100                105                110
Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 
         115                120                125
Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 
     130                135                140
Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 
 145                150                155                160
Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 
                 165                170                175
Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 
             180                185                190
Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 
         195                200                205
Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 
     210                215                220
Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 
 225                230                235                240
Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 
                 245                250                255
Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 
             260                265                270
Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 
         275                280                285
Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 
     290                295                300
Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 
 305                310                315                320
Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 
                 325                330                335
Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 
             340                345                350
Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 
         355                360                365
Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 
     370                375                380
Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 
 385                390                395                400
Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 
                 405                410                415
Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 
             420                425                430
Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 
         435                440                445
Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 
     450                455                460
Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 
 465                470                475                480
Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 
                 485                490                495
Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 
             500                505                510
Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 
         515                520                525
Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 
     530                535                540
Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 
 545                550                555                560
Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 
                 565                570



<210> 9589
<211> 1159
<212> DNA
<213> Rattus norvegicus
<308> X55286
<400> 9589

ccgattagg  ccccaaaac  ggggacgtc  atggggatg  acatgattt  caagggtac  60
gagaaagca  ttctgaagc  tcaagagtt  tttcctgag  tgcagattc  ggcggtcag  120
ggtaactat  gcaccgaca  gaaacctgc  gccataaac  ggatcgaag  gagaggaaa  180
actgtggtt  gtgaagctg  cattccagc  aaggtggtg  gagaagtat  aaagagcac  240
acggaagct  tggttgacg  aaacattaa  aagaatctt  tgggctctg  catggctgg  300
agcatagga  gctacaacg  ccatgctgc  aacatcgtc  ctgccatct  cattgcatg  360
gcccaggat  cagcacaga  tgtggggag  tcaaactgt  ttactttaa  ggaagcaag  420
ggtcccncn  ntgaagact  gnnnnncag  tgnnncatg  cgtctatag  gatcggaac  480
gtgggtggt  ggaccaacc  tctacctca  caagcctgc  tgcagatgc  aggtgttca  540
ggggcgtgc  aagacaatc  tggagaaaa  gcacggcag  ttgcccgaa  tgtgtgtgg  600
actgtaatg  ctggtgagt  gtccttgat  gcagcattg  cagcaggac  tcttgtcag  660
agtcacatg  ttcacaaca  atcaaagat  aatttacaa  atctgcagg  aacatgcac  720
aagaaggca  cttgagcat  ctgacatac  tgaactgaa  cacgggcat  gggttctca  780
ggtctaaca  gaaatctgt  aattaaaaa  gtcagtgca  tgtcttgtg  aagatgaac  840
tgatcagtg  gcctgcttg  tttctggct  tttcagaga  gtctgcggt  ctttgcacc  900
gactcctca  acgtgggaa  tatggttct  tccgtgccg  attctagaa  gatctcatg  960
ggatgtcat  gtgctctga  caccacaga  gtgactgca  ctcgtttct  aaagctgcc  1020
caagctgga  gctggtgtt  tgacgaaat  atggatctt  gtgatcagt  tggggctca  1080
ctccaatgg  ttaaaatgg  gttttaaat  acactgtag  tgacagaac  ctcgatttt  1140
atttattca  tctgggcgg  1159



<210> 9590
<211> 887
<212> PRT
<213> Rattus norvegicus
<308> P51639
<400> 9590

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
  1               5                  10                  15
Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
             20                  25                  30
Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
         35                  40                  45
Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
     50                  55                  60
Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
 65                  70                  75                  80
Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                 85                  90                  95
Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
             100                105                110
Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
         115                120                125
Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Ala Leu Ala Lys Phe Ala 
     130                135                140
Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
 145                150                155                160
Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                 165                170                175
Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
             180                185                190
Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
         195                200                205
Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
     210                215                220
Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
 225                230                235                240
Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                 245                250                255
Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
             260                265                270
Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Glu Gln Ser Lys 
         275                280                285
Val Ser Leu Gly Leu Ala Glu Asp Val Ser Lys Arg Ile Glu Pro Ser 
     290                295                300
Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
 305                310                315                320
Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                 325                330                335
Ile Phe Phe Glu Gln Ala Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
             340                345                350
Pro Ile Thr Ser Pro Val Val Thr Pro Lys Lys Ala Gln Asp Asn Cys 
         355                360                365
Cys Arg Arg Glu Pro Leu Leu Val Arg Arg Asn Gln Lys Leu Ser Ser 
     370                375                380
Val Glu Glu Asp Pro Gly Val Asn Gln Asp Arg Lys Val Glu Val Ile 
 385                390                395                400
Lys Pro Leu Val Ala Glu Ala Glu Thr Ser Gly Arg Ala Thr Phe Val 
                 405                410                415
Leu Gly Ala Ser Ala Ala Ser Pro Pro Leu Ala Leu Gly Ala Gln Glu 
             420                425                430
Pro Gly Ile Glu Leu Pro Ser Glu Pro Arg Pro Asn Glu Glu Cys Leu 
         435                440                445
Gln Ile Leu Glu Ser Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp Ala 
     450                455                460
Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys Leu 
 465                470                475                480
Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg Gln 
                 485                490                495
Leu Leu Ser Ala Lys Leu Ala Glu Pro Ser Ser Leu Gln Tyr Leu Pro 
             500                505                510
Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu Asn 
         515                520                525
Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu Cys 
     530                535                540
Leu Asp Gly Lys Glu Tyr Gln Val Pro Met Ala Thr Thr Glu Gly Cys 
 545                550                555                560
Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Ser Leu Gly Gly 
                 565                570                575
Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Ser Arg Gly Pro Val 
             580                585                590
Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ser Trp Leu 
         595                600                605
Glu Thr Pro Glu Gly Phe Ala Val Val Lys Glu Ala Phe Asp Ser Thr 
     610                615                620
Ser Arg Phe Ala Arg Leu Gln Lys Leu His Val Thr Leu Ala Gly Arg 
 625                630                635                640
Asn Leu Tyr Ile Arg Leu Gln Ser Lys Thr Gly Asp Ala Met Gly Met 
                 645                650                655
Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Leu Lys Leu Gln Glu 
             660                665                670
Gly Val Pro Glu Leu Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys Thr 
         675                680                685
Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Thr 
     690                695                700
Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val Leu 
 705                710                715                720
Lys Thr Thr Thr Glu Ala Met Val Asp Val Asn Ile Asn Lys Asn Leu 
                 725                730                735
Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Leu His Ala 
             740                745                750
Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala Ala 
         755                760                765
Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser Gly 
     770                775                780
Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile Glu 
 785                790                795                800
Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala Cys 
                 805                810                815
Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly Glu 
             820                825                830
Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala Gly 
         835                840                845
Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Arg Ser 
     850                855                860
His Met Val His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln Gly 
 865                870                875                880
Thr Cys Thr Lys Lys Ala Ala 
                 885



<210> 9591
<211> 2904
<212> DNA
<213> Homo sapiens
<308> M11058
<400> 9591

ttcggtggc  tctagtgag  tctggagga  ccaaggatt  tgtagctac  atgttgtca  60
gactttttc  aatgcatgg  ctctttgtg  cctcccatc  ctgggaagt  atagtgggg  120
cagtgacac  gaccatctg  atgatgtcc  tgaacatgt  tactggtaa  aataagatc  180
gtggttgga  ttatgaatg  ccaaagttt  aagaggatg  tttgagcag  gacattata  240
ttctgacaa  aacacgatg  atagccatc  tgtatattt  cttccagtt  cagaattta  300
gtcaacttg  atcaaaata  attttgggt  ttgctggcc  tttcacaat  ttctcaagt  360
ttgtattca  tacagttgt  attcacttc  tagacaaag  attgacagg  ttgaatgaa  420
ctttgccct  tttcctact  ttgattgac  tttccagag  aagcacatt  gcaaagttt  480
ccctcagtt  caactcaca  gatgaagta  gggaaaata  tgctcgtgg  atggcaatt  540
taggtccta  gtttaccct  gatgctctt  ttgaatgtc  tgtgattgg  gttggtacc  600
tgtcagggg  acgtcagct  gaaattatg  gctgctttg  ctgcatgtc  gttcttgcc  660
actacttcg  gttcatgac  ttcttccca  cttgtgtgt  cttggtatt  gagctttct  720
gggaaagcc  cgagggtcg  ccaatttgg  agctcagcc  ttttgcccg  gttttagaa  780
aagaagaaa  taagccgaa  cctgtaact  agagggtca  gatgattat  tctctaggc  840
tggttcttg  tcatgctca  agtcgctgg  tagctgatc  ttctcctca  aacagtaca  900
cagatactt  taaggtttc  ttaggactg  atgaaaatg  gtccaagag  attgaacca  960
gtgtttccc  ctggcagtt  tatctctct  aaatgatca  catggatat  gaacaagtt  1020
ttaccctaa  tttagctct  cttctggct  tcaagtaca  cttctttga  caaacagag  1080
cagaatcta  actctcatt  aaaaaccct  tcacatctc  tgtagtgac  caaaagaaa  1140
tcccagaca  ttgttgtag  cgtgaacct  tgctggtca  aaataacca  aaatgtgat  1200
cagtagagg  agagacagg  ataaaccga  aaagaaaag  tgaggttat  aaaccctta  1260
tggctgaaa  agatacccc  aacagagct  catttgtgg  tggtaactc  tccttactc  1320
atacttcat  agtactggt  acacaggaa  ctgaaattg  acttcccag  gaacctcgg  1380
ctaatgaag  atgtctaca  atacttggg  atgcagaga  aggtgcaaa  ttccttagt  1440
atgctgaga  catccagtt  gtcaatgct  agcatatcc  agcctacaa  ttggaaact  1500
tgatggaaa  tcatgagcg  ggtgtatct  ttcgccgac  gttactttc  aagaagctt  1560
cagaacctt  ttctctcca  tacctacct  acagggatt  taattactc  ttggtgatg  1620
gagcttgtt  tgagaatgt  attggatat  tgcccatcc  tgttggagt  gcaggaccc  1680
tttgcttag  tgaaaaaga  tttcaggtt  caatggcaa  aacagaagg  tgtcttgtg  1740
ccagcacca  tagaggctg  agagcaata  gtcttggtg  aggtgccag  agccgagtc  1800
ttgcagatg  gatgactcg  ggcccagtt  tgcgtcttc  acgtgcttg  gactctgca  1860
aagtgaaag  ctggctcga  acatctgaa  ggttcgcag  gataaagga  gcatttgac  1920
gcactagca  atttgcacg  ctacagaaa  ttcatacaa  tatagctgg  cgcaacctt  1980
atatccgtt  ccagtccag  tcaggggat  ccatgggga  gaacatgat  tcaaagggt  2040
cagagaaag  actttcaaa  cttcacgag  atttccctg  aatgcagat  ctagccgtt  2100
gtggtaact  ttgtactga  aagaaacct  ctgctataa  ttggataga  ggaagagga  2160
aatctgttg  ttgtgaagc  gtcattcca  ccaaggttg  cagagaagt  ttaaagact  2220
ccacagagg  tatgattga  gtcaacatt  acaagaatt  agtgggctc  gccatggct  2280
ggagcatag  aggctacaa  gcccatgca  caaacattg  caccgccat  tacattgcc  2340
gtggacagg  tgcagcaca  aatgttggt  gttcaaact  tattacttt  atggaagca  2400
gtggtccca  aaatgaaga  ttatatatc  gctgcacca  gccatctat  gagatagga  2460
cggtgggtg  tgggaccaa  ctactacct  agcaagcct  tttgcagat  ctaggtgtt  2520
aaggagcat  caaagataa  cctggggaa  atgcccggc  gcttgcccg  attgtgtgt  2580
ggaccgtaa  ggctgggga  ttgtcactt  tggcagcat  ggcagcagg  catcttgtc  2640
aaagtcaca  gattcacaa  aggtcgaag  tcaatttac  agacctcca  ggagcttgc  2700
ccaagaaga  agcctgaat  gcccgacag  tctgaactg  aacatgggc  ttgggttct  2760
aaggactaa  ataaaatct  tgaattaaa  aagctcaat  cattgtctt  tggaggatg  2820
ataaatgtg  tcactgaga  agccacttg  tttttggct  tttcagaga  gtctcaggt  2880
ctttccatg  agactcctc  gatc  2904



<210> 9592
<211> 888
<212> PRT
<213> Homo sapiens
<308> P04035
<400> 9592

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
  1               5                  10                  15
Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
             20                  25                  30
Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
         35                  40                  45
Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
     50                  55                  60
Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
 65                  70                  75                  80
Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                 85                  90                  95
Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
             100                105                110
Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
         115                120                125
Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Thr Leu Ala Lys Phe Ala 
     130                135                140
Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
 145                150                155                160
Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                 165                170                175
Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
             180                185                190
Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
         195                200                205
Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
     210                215                220
Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
 225                230                235                240
Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                 245                250                255
Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
             260                265                270
Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Asp Thr Ser Lys 
         275                280                285
Val Ser Leu Gly Leu Asp Glu Asn Val Ser Lys Arg Ile Glu Pro Ser 
     290                295                300
Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
 305                310                315                320
Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                 325                330                335
Ile Phe Phe Glu Gln Thr Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
             340                345                350
Pro Ile Thr Ser Pro Val Val Thr Gln Lys Lys Val Pro Asp Asn Cys 
         355                360                365
Cys Arg Arg Glu Pro Met Leu Val Arg Asn Asn Gln Lys Cys Asp Ser 
     370                375                380
Val Glu Glu Glu Thr Gly Ile Asn Arg Glu Arg Lys Val Glu Val Ile 
 385                390                395                400
Lys Pro Leu Val Ala Glu Thr Asp Thr Pro Asn Arg Ala Thr Phe Val 
                 405                410                415
Val Gly Asn Ser Ser Leu Leu Asp Thr Ser Ser Val Leu Val Thr Gln 
             420                425                430
Glu Pro Glu Ile Glu Leu Pro Arg Glu Pro Arg Pro Asn Glu Glu Cys 
         435                440                445
Leu Gln Ile Leu Gly Asn Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp 
     450                455                460
Ala Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys 
 465                470                475                480
Leu Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg 
                 485                490                495
Gln Leu Leu Ser Lys Lys Leu Ser Glu Pro Ser Ser Leu Gln Tyr Leu 
             500                505                510
Pro Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu 
         515                520                525
Asn Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu 
     530                535                540
Cys Leu Asp Glu Lys Glu Phe Gln Val Pro Met Ala Thr Thr Glu Gly 
 545                550                555                560
Cys Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Gly Leu Gly 
                 565                570                575
Gly Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Thr Arg Gly Pro 
             580                585                590
Val Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ala Trp 
         595                600                605
Leu Glu Thr Ser Glu Gly Phe Ala Val Ile Lys Glu Ala Phe Asp Ser 
     610                615                620
Thr Ser Arg Phe Ala Arg Leu Gln Lys Leu His Thr Ser Ile Ala Gly 
 625                630                635                640
Arg Asn Leu Tyr Ile Arg Phe Gln Ser Arg Ser Gly Asp Ala Met Gly 
                 645                650                655
Met Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Ser Lys Leu His 
             660                665                670
Glu Tyr Phe Pro Glu Met Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys 
         675                680                685
Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys 
     690                695                700
Ser Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val 
 705                710                715                720
Leu Lys Thr Thr Thr Glu Ala Met Ile Glu Val Asn Ile Asn Lys Asn 
                 725                730                735
Leu Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Ala His 
             740                745                750
Ala Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala 
         755                760                765
Ala Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser 
     770                775                780
Gly Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile 
 785                790                795                800
Glu Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala 
                 805                810                815
Cys Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly 
             820                825                830
Glu Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala 
         835                840                845
Gly Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Lys 
     850                855                860
Ser His Met Ile His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln 
 865                870                875                880
Gly Ala Cys Thr Lys Lys Thr Ala 
                 885



<210> 9593
<211> 1159
<212> DNA
<213> Rattus norvegicus
<308> X55286
<400> 9593

ccgattagg  ccccaaaac  ggggacgtc  atggggatg  acatgattt  caagggtac  60
gagaaagca  ttctgaagc  tcaagagtt  tttcctgag  tgcagattc  ggcggtcag  120
ggtaactat  gcaccgaca  gaaacctgc  gccataaac  ggatcgaag  gagaggaaa  180
actgtggtt  gtgaagctg  cattccagc  aaggtggtg  gagaagtat  aaagagcac  240
acggaagct  tggttgacg  aaacattaa  aagaatctt  tgggctctg  catggctgg  300
agcatagga  gctacaacg  ccatgctgc  aacatcgtc  ctgccatct  cattgcatg  360
gcccaggat  cagcacaga  tgtggggag  tcaaactgt  ttactttaa  ggaagcaag  420
ggtcccncn  ntgaagact  gnnnnncag  tgnnncatg  cgtctatag  gatcggaac  480
gtgggtggt  ggaccaacc  tctacctca  caagcctgc  tgcagatgc  aggtgttca  540
ggggcgtgc  aagacaatc  tggagaaaa  gcacggcag  ttgcccgaa  tgtgtgtgg  600
actgtaatg  ctggtgagt  gtccttgat  gcagcattg  cagcaggac  tcttgtcag  660
agtcacatg  ttcacaaca  atcaaagat  aatttacaa  atctgcagg  aacatgcac  720
aagaaggca  cttgagcat  ctgacatac  tgaactgaa  cacgggcat  gggttctca  780
ggtctaaca  gaaatctgt  aattaaaaa  gtcagtgca  tgtcttgtg  aagatgaac  840
tgatcagtg  gcctgcttg  tttctggct  tttcagaga  gtctgcggt  ctttgcacc  900
gactcctca  acgtgggaa  tatggttct  tccgtgccg  attctagaa  gatctcatg  960
ggatgtcat  gtgctctga  caccacaga  gtgactgca  ctcgtttct  aaagctgcc  1020
caagctgga  gctggtgtt  tgacgaaat  atggatctt  gtgatcagt  tggggctca  1080
ctccaatgg  ttaaaatgg  gttttaaat  acactgtag  tgacagaac  ctcgatttt  1140
atttattca  tctgggcgg  1159



<210> 9594
<211> 887
<212> PRT
<213> Rattus norvegicus
<308> P51639
<400> 9594

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
  1               5                  10                  15
Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
             20                  25                  30
Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
         35                  40                  45
Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
     50                  55                  60
Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
 65                  70                  75                  80
Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                 85                  90                  95
Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
             100                105                110
Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
         115                120                125
Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Ala Leu Ala Lys Phe Ala 
     130                135                140
Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
 145                150                155                160
Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                 165                170                175
Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
             180                185                190
Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
         195                200                205
Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
     210                215                220
Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
 225                230                235                240
Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                 245                250                255
Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
             260                265                270
Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Glu Gln Ser Lys 
         275                280                285
Val Ser Leu Gly Leu Ala Glu Asp Val Ser Lys Arg Ile Glu Pro Ser 
     290                295                300
Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
 305                310                315                320
Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                 325                330                335
Ile Phe Phe Glu Gln Ala Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
             340                345                350
Pro Ile Thr Ser Pro Val Val Thr Pro Lys Lys Ala Gln Asp Asn Cys 
         355                360                365
Cys Arg Arg Glu Pro Leu Leu Val Arg Arg Asn Gln Lys Leu Ser Ser 
     370                375                380
Val Glu Glu Asp Pro Gly Val Asn Gln Asp Arg Lys Val Glu Val Ile 
 385                390                395                400
Lys Pro Leu Val Ala Glu Ala Glu Thr Ser Gly Arg Ala Thr Phe Val 
                 405                410                415
Leu Gly Ala Ser Ala Ala Ser Pro Pro Leu Ala Leu Gly Ala Gln Glu 
             420                425                430
Pro Gly Ile Glu Leu Pro Ser Glu Pro Arg Pro Asn Glu Glu Cys Leu 
         435                440                445
Gln Ile Leu Glu Ser Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp Ala 
     450                455                460
Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys Leu 
 465                470                475                480
Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg Gln 
                 485                490                495
Leu Leu Ser Ala Lys Leu Ala Glu Pro Ser Ser Leu Gln Tyr Leu Pro 
             500                505                510
Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu Asn 
         515                520                525
Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu Cys 
     530                535                540
Leu Asp Gly Lys Glu Tyr Gln Val Pro Met Ala Thr Thr Glu Gly Cys 
 545                550                555                560
Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Ser Leu Gly Gly 
                 565                570                575
Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Ser Arg Gly Pro Val 
             580                585                590
Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ser Trp Leu 
         595                600                605
Glu Thr Pro Glu Gly Phe Ala Val Val Lys Glu Ala Phe Asp Ser Thr 
     610                615                620
Ser Arg Phe Ala Arg Leu Gln Lys Leu His Val Thr Leu Ala Gly Arg 
 625                630                635                640
Asn Leu Tyr Ile Arg Leu Gln Ser Lys Thr Gly Asp Ala Met Gly Met 
                 645                650                655
Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Leu Lys Leu Gln Glu 
             660                665                670
Gly Val Pro Glu Leu Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys Thr 
         675                680                685
Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Thr 
     690                695                700
Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val Leu 
 705                710                715                720
Lys Thr Thr Thr Glu Ala Met Val Asp Val Asn Ile Asn Lys Asn Leu 
                 725                730                735
Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Leu His Ala 
             740                745                750
Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala Ala 
         755                760                765
Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser Gly 
     770                775                780
Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile Glu 
 785                790                795                800
Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala Cys 
                 805                810                815
Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly Glu 
             820                825                830
Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala Gly 
         835                840                845
Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Arg Ser 
     850                855                860
His Met Val His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln Gly 
 865                870                875                880
Thr Cys Thr Lys Lys Ala Ala 
                 885



<210> 9595
<211> 2904
<212> DNA
<213> Homo sapiens
<308> M11058
<400> 9595

ttcggtggc  tctagtgag  tctggagga  ccaaggatt  tgtagctac  atgttgtca  60
gactttttc  aatgcatgg  ctctttgtg  cctcccatc  ctgggaagt  atagtgggg  120
cagtgacac  gaccatctg  atgatgtcc  tgaacatgt  tactggtaa  aataagatc  180
gtggttgga  ttatgaatg  ccaaagttt  aagaggatg  tttgagcag  gacattata  240
ttctgacaa  aacacgatg  atagccatc  tgtatattt  cttccagtt  cagaattta  300
gtcaacttg  atcaaaata  attttgggt  ttgctggcc  tttcacaat  ttctcaagt  360
ttgtattca  tacagttgt  attcacttc  tagacaaag  attgacagg  ttgaatgaa  420
ctttgccct  tttcctact  ttgattgac  tttccagag  aagcacatt  gcaaagttt  480
ccctcagtt  caactcaca  gatgaagta  gggaaaata  tgctcgtgg  atggcaatt  540
taggtccta  gtttaccct  gatgctctt  ttgaatgtc  tgtgattgg  gttggtacc  600
tgtcagggg  acgtcagct  gaaattatg  gctgctttg  ctgcatgtc  gttcttgcc  660
actacttcg  gttcatgac  ttcttccca  cttgtgtgt  cttggtatt  gagctttct  720
gggaaagcc  cgagggtcg  ccaatttgg  agctcagcc  ttttgcccg  gttttagaa  780
aagaagaaa  taagccgaa  cctgtaact  agagggtca  gatgattat  tctctaggc  840
tggttcttg  tcatgctca  agtcgctgg  tagctgatc  ttctcctca  aacagtaca  900
cagatactt  taaggtttc  ttaggactg  atgaaaatg  gtccaagag  attgaacca  960
gtgtttccc  ctggcagtt  tatctctct  aaatgatca  catggatat  gaacaagtt  1020
ttaccctaa  tttagctct  cttctggct  tcaagtaca  cttctttga  caaacagag  1080
cagaatcta  actctcatt  aaaaaccct  tcacatctc  tgtagtgac  caaaagaaa  1140
tcccagaca  ttgttgtag  cgtgaacct  tgctggtca  aaataacca  aaatgtgat  1200
cagtagagg  agagacagg  ataaaccga  aaagaaaag  tgaggttat  aaaccctta  1260
tggctgaaa  agatacccc  aacagagct  catttgtgg  tggtaactc  tccttactc  1320
atacttcat  agtactggt  acacaggaa  ctgaaattg  acttcccag  gaacctcgg  1380
ctaatgaag  atgtctaca  atacttggg  atgcagaga  aggtgcaaa  ttccttagt  1440
atgctgaga  catccagtt  gtcaatgct  agcatatcc  agcctacaa  ttggaaact  1500
tgatggaaa  tcatgagcg  ggtgtatct  ttcgccgac  gttactttc  aagaagctt  1560
cagaacctt  ttctctcca  tacctacct  acagggatt  taattactc  ttggtgatg  1620
gagcttgtt  tgagaatgt  attggatat  tgcccatcc  tgttggagt  gcaggaccc  1680
tttgcttag  tgaaaaaga  tttcaggtt  caatggcaa  aacagaagg  tgtcttgtg  1740
ccagcacca  tagaggctg  agagcaata  gtcttggtg  aggtgccag  agccgagtc  1800
ttgcagatg  gatgactcg  ggcccagtt  tgcgtcttc  acgtgcttg  gactctgca  1860
aagtgaaag  ctggctcga  acatctgaa  ggttcgcag  gataaagga  gcatttgac  1920
gcactagca  atttgcacg  ctacagaaa  ttcatacaa  tatagctgg  cgcaacctt  1980
atatccgtt  ccagtccag  tcaggggat  ccatgggga  gaacatgat  tcaaagggt  2040
cagagaaag  actttcaaa  cttcacgag  atttccctg  aatgcagat  ctagccgtt  2100
gtggtaact  ttgtactga  aagaaacct  ctgctataa  ttggataga  ggaagagga  2160
aatctgttg  ttgtgaagc  gtcattcca  ccaaggttg  cagagaagt  ttaaagact  2220
ccacagagg  tatgattga  gtcaacatt  acaagaatt  agtgggctc  gccatggct  2280
ggagcatag  aggctacaa  gcccatgca  caaacattg  caccgccat  tacattgcc  2340
gtggacagg  tgcagcaca  aatgttggt  gttcaaact  tattacttt  atggaagca  2400
gtggtccca  aaatgaaga  ttatatatc  gctgcacca  gccatctat  gagatagga  2460
cggtgggtg  tgggaccaa  ctactacct  agcaagcct  tttgcagat  ctaggtgtt  2520
aaggagcat  caaagataa  cctggggaa  atgcccggc  gcttgcccg  attgtgtgt  2580
ggaccgtaa  ggctgggga  ttgtcactt  tggcagcat  ggcagcagg  catcttgtc  2640
aaagtcaca  gattcacaa  aggtcgaag  tcaatttac  agacctcca  ggagcttgc  2700
ccaagaaga  agcctgaat  gcccgacag  tctgaactg  aacatgggc  ttgggttct  2760
aaggactaa  ataaaatct  tgaattaaa  aagctcaat  cattgtctt  tggaggatg  2820
ataaatgtg  tcactgaga  agccacttg  tttttggct  tttcagaga  gtctcaggt  2880
ctttccatg  agactcctc  gatc  2904



<210> 9596
<211> 888
<212> PRT
<213> Homo sapiens
<308> P04035
<400> 9596

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
  1               5                  10                  15
Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
             20                  25                  30
Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
         35                  40                  45
Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
     50                  55                  60
Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
 65                  70                  75                  80
Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                 85                  90                  95
Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
             100                105                110
Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
         115                120                125
Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Thr Leu Ala Lys Phe Ala 
     130                135                140
Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
 145                150                155                160
Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                 165                170                175
Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
             180                185                190
Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
         195                200                205
Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
     210                215                220
Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
 225                230                235                240
Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                 245                250                255
Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
             260                265                270
Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Asp Thr Ser Lys 
         275                280                285
Val Ser Leu Gly Leu Asp Glu Asn Val Ser Lys Arg Ile Glu Pro Ser 
     290                295                300
Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
 305                310                315                320
Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                 325                330                335
Ile Phe Phe Glu Gln Thr Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
             340                345                350
Pro Ile Thr Ser Pro Val Val Thr Gln Lys Lys Val Pro Asp Asn Cys 
         355                360                365
Cys Arg Arg Glu Pro Met Leu Val Arg Asn Asn Gln Lys Cys Asp Ser 
     370                375                380
Val Glu Glu Glu Thr Gly Ile Asn Arg Glu Arg Lys Val Glu Val Ile 
 385                390                395                400
Lys Pro Leu Val Ala Glu Thr Asp Thr Pro Asn Arg Ala Thr Phe Val 
                 405                410                415
Val Gly Asn Ser Ser Leu Leu Asp Thr Ser Ser Val Leu Val Thr Gln 
             420                425                430
Glu Pro Glu Ile Glu Leu Pro Arg Glu Pro Arg Pro Asn Glu Glu Cys 
         435                440                445
Leu Gln Ile Leu Gly Asn Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp 
     450                455                460
Ala Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys 
 465                470                475                480
Leu Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg 
                 485                490                495
Gln Leu Leu Ser Lys Lys Leu Ser Glu Pro Ser Ser Leu Gln Tyr Leu 
             500                505                510
Pro Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu 
         515                520                525
Asn Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu 
     530                535                540
Cys Leu Asp Glu Lys Glu Phe Gln Val Pro Met Ala Thr Thr Glu Gly 
 545                550                555                560
Cys Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Gly Leu Gly 
                 565                570                575
Gly Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Thr Arg Gly Pro 
             580                585                590
Val Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ala Trp 
         595                600                605
Leu Glu Thr Ser Glu Gly Phe Ala Val Ile Lys Glu Ala Phe Asp Ser 
     610                615                620
Thr Ser Arg Phe Ala Arg Leu Gln Lys Leu His Thr Ser Ile Ala Gly 
 625                630                635                640
Arg Asn Leu Tyr Ile Arg Phe Gln Ser Arg Ser Gly Asp Ala Met Gly 
                 645                650                655
Met Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Ser Lys Leu His 
             660                665                670
Glu Tyr Phe Pro Glu Met Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys 
         675                680                685
Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys 
     690                695                700
Ser Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val 
 705                710                715                720
Leu Lys Thr Thr Thr Glu Ala Met Ile Glu Val Asn Ile Asn Lys Asn 
                 725                730                735
Leu Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Ala His 
             740                745                750
Ala Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala 
         755                760                765
Ala Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser 
     770                775                780
Gly Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile 
 785                790                795                800
Glu Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala 
                 805                810                815
Cys Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly 
             820                825                830
Glu Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala 
         835                840                845
Gly Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Lys 
     850                855                860
Ser His Met Ile His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln 
 865                870                875                880
Gly Ala Cys Thr Lys Lys Thr Ala 
                 885



<210> 9597
<211> 1159
<212> DNA
<213> Rattus norvegicus
<308> X55286
<400> 9597

ccgattagg  ccccaaaac  ggggacgtc  atggggatg  acatgattt  caagggtac  60
gagaaagca  ttctgaagc  tcaagagtt  tttcctgag  tgcagattc  ggcggtcag  120
ggtaactat  gcaccgaca  gaaacctgc  gccataaac  ggatcgaag  gagaggaaa  180
actgtggtt  gtgaagctg  cattccagc  aaggtggtg  gagaagtat  aaagagcac  240
acggaagct  tggttgacg  aaacattaa  aagaatctt  tgggctctg  catggctgg  300
agcatagga  gctacaacg  ccatgctgc  aacatcgtc  ctgccatct  cattgcatg  360
gcccaggat  cagcacaga  tgtggggag  tcaaactgt  ttactttaa  ggaagcaag  420
ggtcccncn  ntgaagact  gnnnnncag  tgnnncatg  cgtctatag  gatcggaac  480
gtgggtggt  ggaccaacc  tctacctca  caagcctgc  tgcagatgc  aggtgttca  540
ggggcgtgc  aagacaatc  tggagaaaa  gcacggcag  ttgcccgaa  tgtgtgtgg  600
actgtaatg  ctggtgagt  gtccttgat  gcagcattg  cagcaggac  tcttgtcag  660
agtcacatg  ttcacaaca  atcaaagat  aatttacaa  atctgcagg  aacatgcac  720
aagaaggca  cttgagcat  ctgacatac  tgaactgaa  cacgggcat  gggttctca  780
ggtctaaca  gaaatctgt  aattaaaaa  gtcagtgca  tgtcttgtg  aagatgaac  840
tgatcagtg  gcctgcttg  tttctggct  tttcagaga  gtctgcggt  ctttgcacc  900
gactcctca  acgtgggaa  tatggttct  tccgtgccg  attctagaa  gatctcatg  960
ggatgtcat  gtgctctga  caccacaga  gtgactgca  ctcgtttct  aaagctgcc  1020
caagctgga  gctggtgtt  tgacgaaat  atggatctt  gtgatcagt  tggggctca  1080
ctccaatgg  ttaaaatgg  gttttaaat  acactgtag  tgacagaac  ctcgatttt  1140
atttattca  tctgggcgg  1159



<210> 9598
<211> 887
<212> PRT
<213> Rattus norvegicus
<308> P51639
<400> 9598

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
  1               5                  10                  15
Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
             20                  25                  30
Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
         35                  40                  45
Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
     50                  55                  60
Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
 65                  70                  75                  80
Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                 85                  90                  95
Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
             100                105                110
Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
         115                120                125
Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Ala Leu Ala Lys Phe Ala 
     130                135                140
Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
 145                150                155                160
Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                 165                170                175
Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
             180                185                190
Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
         195                200                205
Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
     210                215                220
Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
 225                230                235                240
Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                 245                250                255
Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
             260                265                270
Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Glu Gln Ser Lys 
         275                280                285
Val Ser Leu Gly Leu Ala Glu Asp Val Ser Lys Arg Ile Glu Pro Ser 
     290                295                300
Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
 305                310                315                320
Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                 325                330                335
Ile Phe Phe Glu Gln Ala Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
             340                345                350
Pro Ile Thr Ser Pro Val Val Thr Pro Lys Lys Ala Gln Asp Asn Cys 
         355                360                365
Cys Arg Arg Glu Pro Leu Leu Val Arg Arg Asn Gln Lys Leu Ser Ser 
     370                375                380
Val Glu Glu Asp Pro Gly Val Asn Gln Asp Arg Lys Val Glu Val Ile 
 385                390                395                400
Lys Pro Leu Val Ala Glu Ala Glu Thr Ser Gly Arg Ala Thr Phe Val 
                 405                410                415
Leu Gly Ala Ser Ala Ala Ser Pro Pro Leu Ala Leu Gly Ala Gln Glu 
             420                425                430
Pro Gly Ile Glu Leu Pro Ser Glu Pro Arg Pro Asn Glu Glu Cys Leu 
         435                440                445
Gln Ile Leu Glu Ser Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp Ala 
     450                455                460
Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys Leu 
 465                470                475                480
Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg Gln 
                 485                490                495
Leu Leu Ser Ala Lys Leu Ala Glu Pro Ser Ser Leu Gln Tyr Leu Pro 
             500                505                510
Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu Asn 
         515                520                525
Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu Cys 
     530                535                540
Leu Asp Gly Lys Glu Tyr Gln Val Pro Met Ala Thr Thr Glu Gly Cys 
 545                550                555                560
Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Ser Leu Gly Gly 
                 565                570                575
Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Ser Arg Gly Pro Val 
             580                585                590
Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ser Trp Leu 
         595                600                605
Glu Thr Pro Glu Gly Phe Ala Val Val Lys Glu Ala Phe Asp Ser Thr 
     610                615                620
Ser Arg Phe Ala Arg Leu Gln Lys Leu His Val Thr Leu Ala Gly Arg 
 625                630                635                640
Asn Leu Tyr Ile Arg Leu Gln Ser Lys Thr Gly Asp Ala Met Gly Met 
                 645                650                655
Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Leu Lys Leu Gln Glu 
             660                665                670
Gly Val Pro Glu Leu Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys Thr 
         675                680                685
Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Thr 
     690                695                700
Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val Leu 
 705                710                715                720
Lys Thr Thr Thr Glu Ala Met Val Asp Val Asn Ile Asn Lys Asn Leu 
                 725                730                735
Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Leu His Ala 
             740                745                750
Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala Ala 
         755                760                765
Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser Gly 
     770                775                780
Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile Glu 
 785                790                795                800
Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala Cys 
                 805                810                815
Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly Glu 
             820                825                830
Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala Gly 
         835                840                845
Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Arg Ser 
     850                855                860
His Met Val His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln Gly 
 865                870                875                880
Thr Cys Thr Lys Lys Ala Ala 
                 885



<210> 9599
<211> 2904
<212> DNA
<213> Homo sapiens
<308> M11058
<400> 9599

ttcggtggc  tctagtgag  tctggagga  ccaaggatt  tgtagctac  atgttgtca  60
gactttttc  aatgcatgg  ctctttgtg  cctcccatc  ctgggaagt  atagtgggg  120
cagtgacac  gaccatctg  atgatgtcc  tgaacatgt  tactggtaa  aataagatc  180
gtggttgga  ttatgaatg  ccaaagttt  aagaggatg  tttgagcag  gacattata  240
ttctgacaa  aacacgatg  atagccatc  tgtatattt  cttccagtt  cagaattta  300
gtcaacttg  atcaaaata  attttgggt  ttgctggcc  tttcacaat  ttctcaagt  360
ttgtattca  tacagttgt  attcacttc  tagacaaag  attgacagg  ttgaatgaa  420
ctttgccct  tttcctact  ttgattgac  tttccagag  aagcacatt  gcaaagttt  480
ccctcagtt  caactcaca  gatgaagta  gggaaaata  tgctcgtgg  atggcaatt  540
taggtccta  gtttaccct  gatgctctt  ttgaatgtc  tgtgattgg  gttggtacc  600
tgtcagggg  acgtcagct  gaaattatg  gctgctttg  ctgcatgtc  gttcttgcc  660
actacttcg  gttcatgac  ttcttccca  cttgtgtgt  cttggtatt  gagctttct  720
gggaaagcc  cgagggtcg  ccaatttgg  agctcagcc  ttttgcccg  gttttagaa  780
aagaagaaa  taagccgaa  cctgtaact  agagggtca  gatgattat  tctctaggc  840
tggttcttg  tcatgctca  agtcgctgg  tagctgatc  ttctcctca  aacagtaca  900
cagatactt  taaggtttc  ttaggactg  atgaaaatg  gtccaagag  attgaacca  960
gtgtttccc  ctggcagtt  tatctctct  aaatgatca  catggatat  gaacaagtt  1020
ttaccctaa  tttagctct  cttctggct  tcaagtaca  cttctttga  caaacagag  1080
cagaatcta  actctcatt  aaaaaccct  tcacatctc  tgtagtgac  caaaagaaa  1140
tcccagaca  ttgttgtag  cgtgaacct  tgctggtca  aaataacca  aaatgtgat  1200
cagtagagg  agagacagg  ataaaccga  aaagaaaag  tgaggttat  aaaccctta  1260
tggctgaaa  agatacccc  aacagagct  catttgtgg  tggtaactc  tccttactc  1320
atacttcat  agtactggt  acacaggaa  ctgaaattg  acttcccag  gaacctcgg  1380
ctaatgaag  atgtctaca  atacttggg  atgcagaga  aggtgcaaa  ttccttagt  1440
atgctgaga  catccagtt  gtcaatgct  agcatatcc  agcctacaa  ttggaaact  1500
tgatggaaa  tcatgagcg  ggtgtatct  ttcgccgac  gttactttc  aagaagctt  1560
cagaacctt  ttctctcca  tacctacct  acagggatt  taattactc  ttggtgatg  1620
gagcttgtt  tgagaatgt  attggatat  tgcccatcc  tgttggagt  gcaggaccc  1680
tttgcttag  tgaaaaaga  tttcaggtt  caatggcaa  aacagaagg  tgtcttgtg  1740
ccagcacca  tagaggctg  agagcaata  gtcttggtg  aggtgccag  agccgagtc  1800
ttgcagatg  gatgactcg  ggcccagtt  tgcgtcttc  acgtgcttg  gactctgca  1860
aagtgaaag  ctggctcga  acatctgaa  ggttcgcag  gataaagga  gcatttgac  1920
gcactagca  atttgcacg  ctacagaaa  ttcatacaa  tatagctgg  cgcaacctt  1980
atatccgtt  ccagtccag  tcaggggat  ccatgggga  gaacatgat  tcaaagggt  2040
cagagaaag  actttcaaa  cttcacgag  atttccctg  aatgcagat  ctagccgtt  2100
gtggtaact  ttgtactga  aagaaacct  ctgctataa  ttggataga  ggaagagga  2160
aatctgttg  ttgtgaagc  gtcattcca  ccaaggttg  cagagaagt  ttaaagact  2220
ccacagagg  tatgattga  gtcaacatt  acaagaatt  agtgggctc  gccatggct  2280
ggagcatag  aggctacaa  gcccatgca  caaacattg  caccgccat  tacattgcc  2340
gtggacagg  tgcagcaca  aatgttggt  gttcaaact  tattacttt  atggaagca  2400
gtggtccca  aaatgaaga  ttatatatc  gctgcacca  gccatctat  gagatagga  2460
cggtgggtg  tgggaccaa  ctactacct  agcaagcct  tttgcagat  ctaggtgtt  2520
aaggagcat  caaagataa  cctggggaa  atgcccggc  gcttgcccg  attgtgtgt  2580
ggaccgtaa  ggctgggga  ttgtcactt  tggcagcat  ggcagcagg  catcttgtc  2640
aaagtcaca  gattcacaa  aggtcgaag  tcaatttac  agacctcca  ggagcttgc  2700
ccaagaaga  agcctgaat  gcccgacag  tctgaactg  aacatgggc  ttgggttct  2760
aaggactaa  ataaaatct  tgaattaaa  aagctcaat  cattgtctt  tggaggatg  2820
ataaatgtg  tcactgaga  agccacttg  tttttggct  tttcagaga  gtctcaggt  2880
ctttccatg  agactcctc  gatc  2904



<210> 9600
<211> 888
<212> PRT
<213> Homo sapiens
<308> P04035
<400> 9600

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
  1               5                  10                  15
Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
             20                  25                  30
Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
         35                  40                  45
Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
     50                  55                  60
Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
 65                  70                  75                  80
Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                 85                  90                  95
Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
             100                105                110
Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
         115                120                125
Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Thr Leu Ala Lys Phe Ala 
     130                135                140
Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
 145                150                155                160
Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                 165                170                175
Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
             180                185                190
Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
         195                200                205
Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
     210                215                220
Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
 225                230                235                240
Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                 245                250                255
Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
             260                265                270
Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Asp Thr Ser Lys 
         275                280                285
Val Ser Leu Gly Leu Asp Glu Asn Val Ser Lys Arg Ile Glu Pro Ser 
     290                295                300
Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
 305                310                315                320
Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                 325                330                335
Ile Phe Phe Glu Gln Thr Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
             340                345                350
Pro Ile Thr Ser Pro Val Val Thr Gln Lys Lys Val Pro Asp Asn Cys 
         355                360                365
Cys Arg Arg Glu Pro Met Leu Val Arg Asn Asn Gln Lys Cys Asp Ser 
     370                375                380
Val Glu Glu Glu Thr Gly Ile Asn Arg Glu Arg Lys Val Glu Val Ile 
 385                390                395                400
Lys Pro Leu Val Ala Glu Thr Asp Thr Pro Asn Arg Ala Thr Phe Val 
                 405                410                415
Val Gly Asn Ser Ser Leu Leu Asp Thr Ser Ser Val Leu Val Thr Gln 
             420                425                430
Glu Pro Glu Ile Glu Leu Pro Arg Glu Pro Arg Pro Asn Glu Glu Cys 
         435                440                445
Leu Gln Ile Leu Gly Asn Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp 
     450                455                460
Ala Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys 
 465                470                475                480
Leu Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg 
                 485                490                495
Gln Leu Leu Ser Lys Lys Leu Ser Glu Pro Ser Ser Leu Gln Tyr Leu 
             500                505                510
Pro Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu 
         515                520                525
Asn Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu 
     530                535                540
Cys Leu Asp Glu Lys Glu Phe Gln Val Pro Met Ala Thr Thr Glu Gly 
 545                550                555                560
Cys Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Gly Leu Gly 
                 565                570                575
Gly Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Thr Arg Gly Pro 
             580                585                590
Val Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ala Trp 
         595                600                605
Leu Glu Thr Ser Glu Gly Phe Ala Val Ile Lys Glu Ala Phe Asp Ser 
     610                615                620
Thr Ser Arg Phe Ala Arg Leu Gln Lys Leu His Thr Ser Ile Ala Gly 
 625                630                635                640
Arg Asn Leu Tyr Ile Arg Phe Gln Ser Arg Ser Gly Asp Ala Met Gly 
                 645                650                655
Met Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Ser Lys Leu His 
             660                665                670
Glu Tyr Phe Pro Glu Met Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys 
         675                680                685
Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys 
     690                695                700
Ser Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val 
 705                710                715                720
Leu Lys Thr Thr Thr Glu Ala Met Ile Glu Val Asn Ile Asn Lys Asn 
                 725                730                735
Leu Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Ala His 
             740                745                750
Ala Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala 
         755                760                765
Ala Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser 
     770                775                780
Gly Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile 
 785                790                795                800
Glu Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala 
                 805                810                815
Cys Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly 
             820                825                830
Glu Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala 
         835                840                845
Gly Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Lys 
     850                855                860
Ser His Met Ile His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln 
 865                870                875                880
Gly Ala Cys Thr Lys Lys Thr Ala 
                 885



<210> 9601
<211> 1159
<212> DNA
<213> Rattus norvegicus
<308> X55286
<400> 9601

ccgattagg  ccccaaaac  ggggacgtc  atggggatg  acatgattt  caagggtac  60
gagaaagca  ttctgaagc  tcaagagtt  tttcctgag  tgcagattc  ggcggtcag  120
ggtaactat  gcaccgaca  gaaacctgc  gccataaac  ggatcgaag  gagaggaaa  180
actgtggtt  gtgaagctg  cattccagc  aaggtggtg  gagaagtat  aaagagcac  240
acggaagct  tggttgacg  aaacattaa  aagaatctt  tgggctctg  catggctgg  300
agcatagga  gctacaacg  ccatgctgc  aacatcgtc  ctgccatct  cattgcatg  360
gcccaggat  cagcacaga  tgtggggag  tcaaactgt  ttactttaa  ggaagcaag  420
ggtcccncn  ntgaagact  gnnnnncag  tgnnncatg  cgtctatag  gatcggaac  480
gtgggtggt  ggaccaacc  tctacctca  caagcctgc  tgcagatgc  aggtgttca  540
ggggcgtgc  aagacaatc  tggagaaaa  gcacggcag  ttgcccgaa  tgtgtgtgg  600
actgtaatg  ctggtgagt  gtccttgat  gcagcattg  cagcaggac  tcttgtcag  660
agtcacatg  ttcacaaca  atcaaagat  aatttacaa  atctgcagg  aacatgcac  720
aagaaggca  cttgagcat  ctgacatac  tgaactgaa  cacgggcat  gggttctca  780
ggtctaaca  gaaatctgt  aattaaaaa  gtcagtgca  tgtcttgtg  aagatgaac  840
tgatcagtg  gcctgcttg  tttctggct  tttcagaga  gtctgcggt  ctttgcacc  900
gactcctca  acgtgggaa  tatggttct  tccgtgccg  attctagaa  gatctcatg  960
ggatgtcat  gtgctctga  caccacaga  gtgactgca  ctcgtttct  aaagctgcc  1020
caagctgga  gctggtgtt  tgacgaaat  atggatctt  gtgatcagt  tggggctca  1080
ctccaatgg  ttaaaatgg  gttttaaat  acactgtag  tgacagaac  ctcgatttt  1140
atttattca  tctgggcgg  1159



<210> 9602
<211> 887
<212> PRT
<213> Rattus norvegicus
<308> P51639
<400> 9602

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
  1               5                  10                  15
Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
             20                  25                  30
Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
         35                  40                  45
Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
     50                  55                  60
Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
 65                  70                  75                  80
Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                 85                  90                  95
Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
             100                105                110
Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
         115                120                125
Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Ala Leu Ala Lys Phe Ala 
     130                135                140
Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
 145                150                155                160
Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                 165                170                175
Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
             180                185                190
Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
         195                200                205
Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
     210                215                220
Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
 225                230                235                240
Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                 245                250                255
Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
             260                265                270
Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Glu Gln Ser Lys 
         275                280                285
Val Ser Leu Gly Leu Ala Glu Asp Val Ser Lys Arg Ile Glu Pro Ser 
     290                295                300
Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
 305                310                315                320
Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                 325                330                335
Ile Phe Phe Glu Gln Ala Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
             340                345                350
Pro Ile Thr Ser Pro Val Val Thr Pro Lys Lys Ala Gln Asp Asn Cys 
         355                360                365
Cys Arg Arg Glu Pro Leu Leu Val Arg Arg Asn Gln Lys Leu Ser Ser 
     370                375                380
Val Glu Glu Asp Pro Gly Val Asn Gln Asp Arg Lys Val Glu Val Ile 
 385                390                395                400
Lys Pro Leu Val Ala Glu Ala Glu Thr Ser Gly Arg Ala Thr Phe Val 
                 405                410                415
Leu Gly Ala Ser Ala Ala Ser Pro Pro Leu Ala Leu Gly Ala Gln Glu 
             420                425                430
Pro Gly Ile Glu Leu Pro Ser Glu Pro Arg Pro Asn Glu Glu Cys Leu 
         435                440                445
Gln Ile Leu Glu Ser Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp Ala 
     450                455                460
Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys Leu 
 465                470                475                480
Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg Gln 
                 485                490                495
Leu Leu Ser Ala Lys Leu Ala Glu Pro Ser Ser Leu Gln Tyr Leu Pro 
             500                505                510
Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu Asn 
         515                520                525
Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu Cys 
     530                535                540
Leu Asp Gly Lys Glu Tyr Gln Val Pro Met Ala Thr Thr Glu Gly Cys 
 545                550                555                560
Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Ser Leu Gly Gly 
                 565                570                575
Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Ser Arg Gly Pro Val 
             580                585                590
Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ser Trp Leu 
         595                600                605
Glu Thr Pro Glu Gly Phe Ala Val Val Lys Glu Ala Phe Asp Ser Thr 
     610                615                620
Ser Arg Phe Ala Arg Leu Gln Lys Leu His Val Thr Leu Ala Gly Arg 
 625                630                635                640
Asn Leu Tyr Ile Arg Leu Gln Ser Lys Thr Gly Asp Ala Met Gly Met 
                 645                650                655
Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Leu Lys Leu Gln Glu 
             660                665                670
Gly Val Pro Glu Leu Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys Thr 
         675                680                685
Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Thr 
     690                695                700
Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val Leu 
 705                710                715                720
Lys Thr Thr Thr Glu Ala Met Val Asp Val Asn Ile Asn Lys Asn Leu 
                 725                730                735
Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Leu His Ala 
             740                745                750
Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala Ala 
         755                760                765
Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser Gly 
     770                775                780
Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile Glu 
 785                790                795                800
Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala Cys 
                 805                810                815
Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly Glu 
             820                825                830
Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala Gly 
         835                840                845
Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Arg Ser 
     850                855                860
His Met Val His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln Gly 
 865                870                875                880
Thr Cys Thr Lys Lys Ala Ala 
                 885



<210> 9603
<211> 2904
<212> DNA
<213> Homo sapiens
<308> M11058
<400> 9603

ttcggtggc  tctagtgag  tctggagga  ccaaggatt  tgtagctac  atgttgtca  60
gactttttc  aatgcatgg  ctctttgtg  cctcccatc  ctgggaagt  atagtgggg  120
cagtgacac  gaccatctg  atgatgtcc  tgaacatgt  tactggtaa  aataagatc  180
gtggttgga  ttatgaatg  ccaaagttt  aagaggatg  tttgagcag  gacattata  240
ttctgacaa  aacacgatg  atagccatc  tgtatattt  cttccagtt  cagaattta  300
gtcaacttg  atcaaaata  attttgggt  ttgctggcc  tttcacaat  ttctcaagt  360
ttgtattca  tacagttgt  attcacttc  tagacaaag  attgacagg  ttgaatgaa  420
ctttgccct  tttcctact  ttgattgac  tttccagag  aagcacatt  gcaaagttt  480
ccctcagtt  caactcaca  gatgaagta  gggaaaata  tgctcgtgg  atggcaatt  540
taggtccta  gtttaccct  gatgctctt  ttgaatgtc  tgtgattgg  gttggtacc  600
tgtcagggg  acgtcagct  gaaattatg  gctgctttg  ctgcatgtc  gttcttgcc  660
actacttcg  gttcatgac  ttcttccca  cttgtgtgt  cttggtatt  gagctttct  720
gggaaagcc  cgagggtcg  ccaatttgg  agctcagcc  ttttgcccg  gttttagaa  780
aagaagaaa  taagccgaa  cctgtaact  agagggtca  gatgattat  tctctaggc  840
tggttcttg  tcatgctca  agtcgctgg  tagctgatc  ttctcctca  aacagtaca  900
cagatactt  taaggtttc  ttaggactg  atgaaaatg  gtccaagag  attgaacca  960
gtgtttccc  ctggcagtt  tatctctct  aaatgatca  catggatat  gaacaagtt  1020
ttaccctaa  tttagctct  cttctggct  tcaagtaca  cttctttga  caaacagag  1080
cagaatcta  actctcatt  aaaaaccct  tcacatctc  tgtagtgac  caaaagaaa  1140
tcccagaca  ttgttgtag  cgtgaacct  tgctggtca  aaataacca  aaatgtgat  1200
cagtagagg  agagacagg  ataaaccga  aaagaaaag  tgaggttat  aaaccctta  1260
tggctgaaa  agatacccc  aacagagct  catttgtgg  tggtaactc  tccttactc  1320
atacttcat  agtactggt  acacaggaa  ctgaaattg  acttcccag  gaacctcgg  1380
ctaatgaag  atgtctaca  atacttggg  atgcagaga  aggtgcaaa  ttccttagt  1440
atgctgaga  catccagtt  gtcaatgct  agcatatcc  agcctacaa  ttggaaact  1500
tgatggaaa  tcatgagcg  ggtgtatct  ttcgccgac  gttactttc  aagaagctt  1560
cagaacctt  ttctctcca  tacctacct  acagggatt  taattactc  ttggtgatg  1620
gagcttgtt  tgagaatgt  attggatat  tgcccatcc  tgttggagt  gcaggaccc  1680
tttgcttag  tgaaaaaga  tttcaggtt  caatggcaa  aacagaagg  tgtcttgtg  1740
ccagcacca  tagaggctg  agagcaata  gtcttggtg  aggtgccag  agccgagtc  1800
ttgcagatg  gatgactcg  ggcccagtt  tgcgtcttc  acgtgcttg  gactctgca  1860
aagtgaaag  ctggctcga  acatctgaa  ggttcgcag  gataaagga  gcatttgac  1920
gcactagca  atttgcacg  ctacagaaa  ttcatacaa  tatagctgg  cgcaacctt  1980
atatccgtt  ccagtccag  tcaggggat  ccatgggga  gaacatgat  tcaaagggt  2040
cagagaaag  actttcaaa  cttcacgag  atttccctg  aatgcagat  ctagccgtt  2100
gtggtaact  ttgtactga  aagaaacct  ctgctataa  ttggataga  ggaagagga  2160
aatctgttg  ttgtgaagc  gtcattcca  ccaaggttg  cagagaagt  ttaaagact  2220
ccacagagg  tatgattga  gtcaacatt  acaagaatt  agtgggctc  gccatggct  2280
ggagcatag  aggctacaa  gcccatgca  caaacattg  caccgccat  tacattgcc  2340
gtggacagg  tgcagcaca  aatgttggt  gttcaaact  tattacttt  atggaagca  2400
gtggtccca  aaatgaaga  ttatatatc  gctgcacca  gccatctat  gagatagga  2460
cggtgggtg  tgggaccaa  ctactacct  agcaagcct  tttgcagat  ctaggtgtt  2520
aaggagcat  caaagataa  cctggggaa  atgcccggc  gcttgcccg  attgtgtgt  2580
ggaccgtaa  ggctgggga  ttgtcactt  tggcagcat  ggcagcagg  catcttgtc  2640
aaagtcaca  gattcacaa  aggtcgaag  tcaatttac  agacctcca  ggagcttgc  2700
ccaagaaga  agcctgaat  gcccgacag  tctgaactg  aacatgggc  ttgggttct  2760
aaggactaa  ataaaatct  tgaattaaa  aagctcaat  cattgtctt  tggaggatg  2820
ataaatgtg  tcactgaga  agccacttg  tttttggct  tttcagaga  gtctcaggt  2880
ctttccatg  agactcctc  gatc  2904



<210> 9604
<211> 888
<212> PRT
<213> Homo sapiens
<308> P04035
<400> 9604

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
  1               5                  10                  15
Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
             20                  25                  30
Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
         35                  40                  45
Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
     50                  55                  60
Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
 65                  70                  75                  80
Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                 85                  90                  95
Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
             100                105                110
Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
         115                120                125
Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Thr Leu Ala Lys Phe Ala 
     130                135                140
Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
 145                150                155                160
Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                 165                170                175
Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
             180                185                190
Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
         195                200                205
Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
     210                215                220
Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
 225                230                235                240
Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                 245                250                255
Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
             260                265                270
Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Asp Thr Ser Lys 
         275                280                285
Val Ser Leu Gly Leu Asp Glu Asn Val Ser Lys Arg Ile Glu Pro Ser 
     290                295                300
Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
 305                310                315                320
Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                 325                330                335
Ile Phe Phe Glu Gln Thr Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
             340                345                350
Pro Ile Thr Ser Pro Val Val Thr Gln Lys Lys Val Pro Asp Asn Cys 
         355                360                365
Cys Arg Arg Glu Pro Met Leu Val Arg Asn Asn Gln Lys Cys Asp Ser 
     370                375                380
Val Glu Glu Glu Thr Gly Ile Asn Arg Glu Arg Lys Val Glu Val Ile 
 385                390                395                400
Lys Pro Leu Val Ala Glu Thr Asp Thr Pro Asn Arg Ala Thr Phe Val 
                 405                410                415
Val Gly Asn Ser Ser Leu Leu Asp Thr Ser Ser Val Leu Val Thr Gln 
             420                425                430
Glu Pro Glu Ile Glu Leu Pro Arg Glu Pro Arg Pro Asn Glu Glu Cys 
         435                440                445
Leu Gln Ile Leu Gly Asn Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp 
     450                455                460
Ala Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys 
 465                470                475                480
Leu Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg 
                 485                490                495
Gln Leu Leu Ser Lys Lys Leu Ser Glu Pro Ser Ser Leu Gln Tyr Leu 
             500                505                510
Pro Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu 
         515                520                525
Asn Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu 
     530                535                540
Cys Leu Asp Glu Lys Glu Phe Gln Val Pro Met Ala Thr Thr Glu Gly 
 545                550                555                560
Cys Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Gly Leu Gly 
                 565                570                575
Gly Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Thr Arg Gly Pro 
             580                585                590
Val Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ala Trp 
         595                600                605
Leu Glu Thr Ser Glu Gly Phe Ala Val Ile Lys Glu Ala Phe Asp Ser 
     610                615                620
Thr Ser Arg Phe Ala Arg Leu Gln Lys Leu His Thr Ser Ile Ala Gly 
 625                630                635                640
Arg Asn Leu Tyr Ile Arg Phe Gln Ser Arg Ser Gly Asp Ala Met Gly 
                 645                650                655
Met Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Ser Lys Leu His 
             660                665                670
Glu Tyr Phe Pro Glu Met Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys 
         675                680                685
Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys 
     690                695                700
Ser Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val 
 705                710                715                720
Leu Lys Thr Thr Thr Glu Ala Met Ile Glu Val Asn Ile Asn Lys Asn 
                 725                730                735
Leu Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Ala His 
             740                745                750
Ala Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala 
         755                760                765
Ala Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser 
     770                775                780
Gly Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile 
 785                790                795                800
Glu Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala 
                 805                810                815
Cys Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly 
             820                825                830
Glu Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala 
         835                840                845
Gly Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Lys 
     850                855                860
Ser His Met Ile His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln 
 865                870                875                880
Gly Ala Cys Thr Lys Lys Thr Ala 
                 885



<210> 9605
<211> 2153
<212> DNA
<213> Rattus norvegicus
<308> X55446
<400> 9605

gagggctaa  atggagctg  tgggattca  tacgcttgc  cttgtggtt  cggtgactt  60
cctcagcct  ctttcagtg  ggacaaaac  gcgcactag  gggaggctg  ccccggggc  120
ccacccccc  tcccattat  gggaatcta  tgcaactga  cctcaagga  atcctgcat  180
gctttccaa  ctggccaaa  agtacgggc  tgtttacac  ctgtacttt  gaacctctc  240
tactgtggt  ctgcatggc  atgatgtgg  gaaggaggc  cttctccag  aaggggatg  300
gttcctcgg  agaggacct  tgcccatca  cgaagatac  cataaggga  atggactca  360
tttcagtaa  ggagagagg  ggaaagtca  gcgacgctt  tccctcatg  ctctgagga  420
cttcggaat  gggaagaga  gcctagagg  gagggtgca  gaggaagcc  ggtgccttg  480
ggaggaatt  caaaaaaca  aagctcagc  ctttgaccc  accttcatc  tggcctgtg  540
tccctgcaa  gtgatctgc  ccattcttt  caacgatcg  ttccagtac  acgacaaga  600
gttcctcaa  cttatggat  ttttaaata  aaattttca  caagtgaac  ccgtgtggt  660
ccagatgta  aacctttgg  caacgatca  aaagtatct  cctggaaag  atatagaat  720
tgcaaaaag  attgatgat  ttaaaaact  cattcttga  aaagtgaag  aacaccaga  780
gtccctgga  cctgccaac  ctcgggact  cattgactg  tttctcagc  agattgagg  840
ggagaagga  aacctgaag  ctgagttcc  tctggagaa  ttggctgtc  gtgggtcta  900
cttgtttac  gcaggcacc  agacaacca  caccaccct  agattcggg  tcctgctcc  960
tatgaagta  ccagaggtg  aagccaaag  tcatgagga  cttgaccgt  tgattggac  1020
ccaccaacc  cccagcatg  aggacaaga  gaagctgcc  tataccgat  ctgtattgc  1080
tgagattca  agatacatc  ctctggttg  ttccagtct  ccccatgct  tggtccagg  1140
cacaaaatt  agagactat  tcatcccca  gggtactac  gtactcccg  tgctgtctt  1200
cgtcatgct  gatcaaaag  agtttgcca  cccagagaa  tttgatcca  gacactttc  1260
ggataaaaa  ggctgcttc  agaagacag  ctactttgt  cccttctcc  ttggaaagc  1320
ggcctgtgt  ggtgagagt  tggcccgga  ggagctctt  ctgttcttc  ccacccttc  1380
gcaaaagtt  tccctgaag  ctctggtgg  gcccaagga  cttgacatc  agcctatta  1440
taccgggat  atcaatttg  cgccacctt  caagctgtg  cttgttcct  gataagggt  1500
tatcctttt  atcattcaa  tcaaagtaa  tgtttcctt  ttctataaa  attcttttt  1560
tgctaagca  tgcctaggc  agaaacatc  tgcatgaaa  ccacatgga  atttatttc  1620
atttaaaaa  ctaggtctt  aaagcttcc  ggacacagg  agtgtgtct  tgtccctca  1680
ctgctctag  aaccaggcc  caagcacaa  tgacaccag  tatgcaaga  cctcatcag  1740
cgccaccta  aagtagcac  gtgtgctct  ctgtagctt  ggaaataga  ttgttttct  1800
tcattgttt  aatagagaa  ttaatgtaa  ggcctacgt  cattttcct  ttcacactt  1860
aaaacattt  catgatttg  gccacattc  caaaataaa  tctcaccct  acaataaaa  1920
aaaaggaat  cctgttggc  gagttgtca  tcagcgtga  ctctgccac  agctcccta  1980
gaaggggca  tgaaggacc  ttcataggt  tttggaggt  ataaagcca  gatatcata  2040
agccttaag  ggaccattg  agcactagc  ttcaggtgg  ggaattcca  aaaaaaaaa  2100
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaagg  att  2153



<210> 9606
<211> 494
<212> PRT
<213> Rattus norvegicus
<308> P24470
<400> 9606

Met Glu Leu Leu Gly Phe Thr Thr Leu Ala Leu Val Val Ser Val Thr 
  1               5                  10                  15
Cys Leu Ser Leu Leu Ser Val Trp Thr Lys Leu Arg Thr Arg Gly Arg 
             20                  25                  30
Leu Pro Pro Gly Pro Thr Pro Leu Pro Ile Ile Gly Asn Leu Leu Gln 
         35                  40                  45
Leu Asn Leu Lys Asp Ile Pro Ala Ser Leu Ser Lys Leu Ala Lys Glu 
     50                  55                  60
Tyr Gly Pro Val Tyr Thr Leu Tyr Phe Gly Thr Ser Pro Thr Val Val 
 65                  70                  75                  80
Leu His Gly Tyr Asp Val Val Lys Glu Ala Leu Leu Gln Gln Gly Asp 
                 85                  90                  95
Glu Phe Leu Gly Arg Gly Pro Leu Pro Ile Ile Glu Asp Thr His Lys 
             100                105                110
Gly Tyr Gly Leu Ile Phe Ser Asn Gly Glu Arg Trp Lys Val Met Arg 
         115                120                125
Arg Phe Ser Leu Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser 
     130                135                140
Leu Glu Glu Arg Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu 
 145                150                155                160
Gln Lys Thr Lys Ala Gln Pro Phe Asp Pro Thr Phe Ile Leu Ala Cys 
                 165                170                175
Ala Pro Cys Asn Val Ile Cys Ser Ile Leu Phe Asn Asp Arg Phe Gln 
             180                185                190
Tyr Asn Asp Lys Thr Phe Leu Asn Leu Met Asp Leu Leu Asn Lys Asn 
         195                200                205
Phe Gln Gln Val Asn Ser Val Trp Cys Gln Met Tyr Asn Leu Trp Pro 
     210                215                220
Thr Ile Ile Lys Tyr Leu Pro Gly Lys His Ile Glu Phe Ala Lys Arg 
 225                230                235                240
Ile Asp Asp Val Lys Asn Phe Ile Leu Glu Lys Val Lys Glu His Gln 
                 245                250                255
Lys Ser Leu Asp Pro Ala Asn Pro Arg Asp Tyr Ile Asp Cys Phe Leu 
             260                265                270
Ser Lys Ile Glu Glu Glu Lys Asp Asn Leu Lys Ser Glu Phe His Leu 
         275                280                285
Glu Asn Leu Ala Val Cys Gly Ser Asn Leu Phe Thr Ala Gly Thr Glu 
     290                295                300
Thr Thr Ser Thr Thr Leu Arg Phe Gly Leu Leu Leu Leu Met Lys Tyr 
 305                310                315                320
Pro Glu Val Gln Ala Lys Val His Glu Glu Leu Asp Arg Val Ile Gly 
                 325                330                335
Arg His Gln Pro Pro Ser Met Lys Asp Lys Met Lys Leu Pro Tyr Thr 
             340                345                350
Asp Ala Val Leu His Glu Ile Gln Arg Tyr Ile Thr Leu Leu Pro Ser 
         355                360                365
Ser Leu Pro His Ala Val Val Gln Asp Thr Lys Phe Arg Asp Tyr Val 
     370                375                380
Ile Pro Lys Gly Thr Thr Val Leu Pro Met Leu Ser Ser Val Met Leu 
 385                390                395                400
Asp Gln Lys Glu Phe Ala Asn Pro Glu Lys Phe Asp Pro Gly His Phe 
                 405                410                415
Leu Asp Lys Asn Gly Cys Phe Lys Lys Thr Asp Tyr Phe Val Pro Phe 
             420                425                430
Ser Leu Gly Lys Arg Ala Cys Val Gly Glu Ser Leu Ala Arg Met Glu 
         435                440                445
Leu Phe Leu Phe Phe Thr Thr Leu Leu Gln Lys Phe Ser Leu Lys Thr 
     450                455                460
Leu Val Glu Pro Lys Asp Leu Asp Ile Lys Pro Ile Thr Thr Gly Ile 
 465                470                475                480
Ile Asn Leu Pro Pro Pro Tyr Lys Leu Cys Leu Val Pro Arg 
                 485                490



<210> 9607
<211> 566
<212> DNA
<213> Homo sapiens
<308> AW450584
<400> 9607

cggccgctc  gcatgtccg  gcactttct  ctcgcaccc  tccccgagt  ctcctcgga  60
tacctactg  ccaaggaca  caaactggc  gtactgggc  ccggccgcg  gggcaagag  120
gcaatgatc  tgcgcttcc  gaccaagag  ttcattgga  actatgaac  gaatacagg  180
aagctgtat  cacggctgg  ctatgtcga  ggggaccag  tctccctgc  gatccagga  240
actcccggg  gcgtccaga  ccaagacag  ctcccccag  tcgtcgatt  cctgtccaa  300
tgcgtgcag  gggccgagg  ttttctgct  gtctattcc  tcacagact  tgacagcta  360
ttgtccatc  gaccccttt  tcagcacat  cggaaggtc  accctgact  taaagcccc  420
gtcatcatc  tgggcaaca  gggggacct  ttgcatgcc  ggcaggtgc  gacacagga  480
ggtattcag  tagccaatg  gctgggcag  ctgttcctt  aaatttcca  tagcganaa  540
taccaagat  tctgtgatg  gtttca  566



<210> 9608
<211> 490
<212> PRT
<213> Homo sapiens
<308> NP_000760
<400> 9608

Met Asp Pro Phe Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
  1               5                  10                  15
Leu Ser Ile Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
             20                  25                  30
Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Asp Ile Lys 
         35                  40                  45
Asp Val Ser Lys Ser Leu Thr Asn Leu Ser Lys Ile Tyr Gly Pro Val 
     50                  55                  60
Phe Thr Leu Tyr Phe Gly Leu Glu Arg Met Val Val Leu His Gly Tyr 
 65                  70                  75                  80
Glu Val Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                 85                  90                  95
Arg Gly His Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
             100                105                110
Val Phe Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu 
         115                120                125
Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
     130                135                140
Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
 145                150                155                160
Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                 165                170                175
Val Ile Cys Ser Ile Ile Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln 
             180                185                190
Gln Phe Leu Asn Leu Met Glu Lys Leu Asn Glu Asn Ile Arg Ile Val 
         195                200                205
Ser Thr Pro Trp Ile Gln Ile Cys Asn Asn Phe Pro Thr Ile Ile Asp 
     210                215                220
Tyr Phe Pro Gly Thr His Asn Lys Leu Leu Lys Asn Leu Ala Phe Met 
 225                230                235                240
Glu Ser Asp Ile Leu Glu Lys Val Lys Glu His Gln Glu Ser Met Asp 
                 245                250                255
Ile Asn Asn Pro Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
             260                265                270
Lys Glu Lys Gln Asn Gln Gln Ser Glu Phe Thr Ile Glu Asn Leu Val 
         275                280                285
Ile Thr Ala Ala Asp Leu Leu Gly Ala Gly Thr Glu Thr Thr Ser Thr 
     290                295                300
Thr Leu Arg Tyr Ala Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
 305                310                315                320
Ala Lys Val Gln Glu Glu Ile Glu Arg Val Ile Gly Arg Asn Arg Ser 
                 325                330                335
Pro Cys Met Gln Asp Arg Gly His Met Pro Tyr Thr Asp Ala Val Val 
             340                345                350
His Glu Val Gln Arg Tyr Ile Asp Leu Ile Pro Thr Ser Leu Pro His 
         355                360                365
Ala Val Thr Cys Asp Val Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
     370                375                380
Thr Thr Ile Leu Thr Ser Leu Thr Ser Val Leu His Asp Asn Lys Glu 
 385                390                395                400
Phe Pro Asn Pro Glu Met Phe Asp Pro Arg His Phe Leu Asp Glu Gly 
                 405                410                415
Gly Asn Phe Lys Lys Ser Asn Tyr Phe Met Pro Phe Ser Ala Gly Lys 
             420                425                430
Arg Ile Cys Val Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
         435                440                445
Leu Thr Phe Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Ile Asp Pro 
     450                455                460
Lys Asp Leu Asp Thr Thr Pro Val Val Asn Gly Phe Ala Ser Val Pro 
 465                470                475                480
Pro Phe Tyr Gln Leu Cys Phe Ile Pro Val 
                 485                490



<210> 9609
<211> 4259
<212> DNA
<213> Rattus norvegicus
<308> X55660
<400> 9609

aaaaaagag  attccgtgg  ttaaaaaaa  agtttgaaa  cctctgact  aatagtttc  60
accaccaag  aaactgagg  ccagagaga  gaaatgacc  gggtaagat  tccgaggga  120
cagtagttg  acagggact  ggagttaaa  tttcatggg  ggtgcctgt  acaggacct  180
ccttggggt  tctgctgga  agagagacc  gattgggtt  cccagcagt  ttcagtggc  240
tgctccgtg  ctgcctcag  caggtctcc  gcagccaca  ctggggatc  ggcccccgt  300
ctgtcctcc  gccccaccc  cctcggctc  atgcccccc  cagtcagct  cgggaccct  360
gcagtgagc  ggcacgtgg  agccaaggc  ctgtgacca  gccagggag  cggagctct  420
gggtcccag  cacctgccc  cccatggag  tgagaccct  gttgctatg  gtggtagca  480
cagcaggag  cttggtcct  ctagcagct  aagctcgcg  ccagaagat  ttcaccaac  540
cgtgggctg  gcacatttc  ggaggccca  ctgtggctg  tagtgtggc  cggaagcat  600
ggttccaca  cctgggcca  atcttcggt  actattacc  cttctggca  agagcagtg  660
caaagcggt  cctgtcgcc  caccgcccg  ggcacagcc  gctacagag  gtgcctcaa  720
tgaagtggc  ggagcagca  gtagccaag  aaagggcca  gagggacgt  tatcaggag  780
ccacagacc  caagttccc  cagcagtgg  acctgtctg  ggtcactca  cgagacctg  840
atgtgaagg  agcctgggc  cagggcttc  cagggcgtg  cattgtggt  tccatcctg  900
atgacggca  tgaaaagaa  catcctgac  tggcaggca  ttatgaccc  ggagccagc  960
ttgatgtca  tgaccagga  cctgaccca  agcctcggt  cacgcagat  aatgacaac  1020
ggcacggca  tcggtgtgc  ggggaagtg  cagcggtgg  caacaatgg  gtctgtggt  1080
taggtgtag  ttacaatgc  cggattgga  gggtgcgta  gttggatgg  gaggtgact  1140
acgcggtag  ggcacgttc  ctgggcctg  atcccaacc  catccacat  tacagcgcc  1200
gctggggcc  cgaggacga  ggcaagacc  tggatgggc  agcccggct  gccgaggag  1260
ccttctttc  gggagttag  cagggccgc  gagggctgg  ctccatctt  gtctgggcc  1320
cagggaatg  gggccggga  catgacagc  gtaactgtg  cggctacac  aacagtatc  1380
acacgctgt  catcagcag  gccacacaa  tcggcaacg  gccctggta  agtgaggcc  1440
gctcctcca  actggccac  acctacagc  gtggcaacc  gaatgagaa  cagattgtg  1500
caactgact  gaggcagaa  tgcactgag  ctcacacag  cacctcagc  tccgcccct  1560
tggcagctg  tatcattgc  ctcaccctg  aggccaaca  gaacctcac  tggcgggac  1620
tgcagcacc  ggtggtgca  acctcaaag  cagcacatc  caacgctaa  gattgggcc  1680
ccaatggcg  gggccggaa  gtgagccat  cctatggct  cgggctgtt  gatgcaggt  1740
ccatggtgg  cctggccca  aactggaca  cagtggccc  ccagcggaa  tgcatcatt  1800
aaatcctgg  agagcccaa  gacattggc  aacggctag  ggtgcgcaa  accgtgaca  1860
cgtgcctgg  tgagcccaa  cacatctcc  gactggaac  cgttcaggc  cggctcacc  1920
tgtcttaca  tcgccgtgg  gacctggct  tccacctca  cagccccat  ggcacccgt  1980
ccaccctat  agctgccag  ccacatgac  actctgctg  tggatttaa  gactgggct  2040
tcatgacaa  tcattcctg  gatgaggac  cctctggcg  gtgggtcct  gagattgaa  2100
ataccagcg  ggccaacaa  tatgggacg  tgaccaagt  cactctcgt  ctatatggc  2160
cagcctctg  gggtctctc  gcacctcca  agagcagcg  ctgcaagac  ctcacatcc  2220
gccaggcct  cgtggtgtg  gaggaaggt  tctcactgc  ccagaaaag  tgtgtccag  2280
gttgcccac  aggcttcac  ccccaagtc  ttgatacac  ctacagcac  gagaatgat  2340
tggagatca  ccgtgccag  gtctgcacc  cctgccacg  ctcatgtgc  acttgccag  2400
gcccagctc  cacagactg  ctcagctgc  ccagccatg  ctccctgga  cctgtggag  2460
aaacctgct  ccggcaaag  cagagcagc  gagagtccc  acctcagca  ccacctccc  2520
cactgcgcc  agaggtgga  gtggagccc  ggttgcggg  tgggctggc  tctcacctg  2580
cggaggtcc  ggccggcct  agctgcctt  tcatcgctc  catctttgg  atcgtcttc  2640
tcttcctgc  tcggtgttc  ggcttcagc  tccggggag  gaaagtgta  accatggac  2700
gtggcctca  ctcctacaa  gggctgcct  ctgaggcct  gcaggagga  tgcccatct  2760
actcagaag  ggatgaggg  cggggcgag  ggaccgcct  tatcaaaga  cagagcgcc  2820
tttgatgag  ccactgccc  ccctatcaa  tcgatccct  cctcggcac  ttttaattc  2880
ccaaagtat  tttttatct  gggactggg  ttggaccct  gctgggagg  gagaggggc  2940
gagaccctt  ggcctacct  tttgcctga  gtggggtcc  gggagcctc  ccccccacc  3000
accctccat  tggaggaag  agtaaatct  tagggcagc  tcctgcaga  tgaagaggg  3060
cagcctttc  gactccctg  ccagctgca  ccttgcccc  cccctgccc  tcagaaagc  3120
ataatggtc  ccatccagg  aacagggag  ctggccagg  ggtacttga  gaaggtggc  3180
acctctcca  gggcttttg  atcccctga  cctctctgg  tcaggatga  cctctgaag  3240
agcttgcag  cacaggaag  gaccaaagc  aacgaggca  tctccagtg  gcctgcact  3300
ttgctctca  cctgcctct  cactccagg  ctccacctc  gctggtagc  aggctgagc  3360
agacctgca  aggtcaggc  ctggggcct  atgctggtg  cctgaccat  ctctatggc  3420
ccccccccc  aagccaggg  cttgttttc  gagcccggg  ctgcctggg  agttggcgc  3480
cacagtcca  gagcccctg  gtgggtggt  gggagggac  gtggctcct  ccacctccc  3540
cccgatgct  ctttcccct  tggggatct  aggagctgt  tgaggatat  ttttcactt  3600
gtgattatt  actttagat  ctgattttt  tttttttgt  tttttaatg  gggtagcag  3660
tggaccatt  accttctcc  acccatgtc  accctgcct  tcccatggc  gcccagctc  3720
gaggcagag  gaatcacta  gccccaagt  ctgaagagg  aggccagcc  gctgggctc  3780
aggaaaggg  gtcatggtg  gaggggtag  ctgacatca  ctgtttcaa  tggggttgt  3840
ccacaggct  ttgggttgc  ggctctcca  gtgccaggg  tgggcaggt  gcaccacca  3900
gcccaaact  acactgtgc  ctggtggag  aagcattgg  ctatgatgc  ccccaaacc  3960
cctgttctg  tgtgccttt  gcacccctc  cattaggac  atcagtccc  tcccacttg  4020
gcctcctct  ttctttttc  tagcccttc  cggtaccca  cctacctgt  cagggtgcc  4080
cttgctctc  tgcccaccc  tagcggcca  ccaggctgg  tttgtaaga  gctgggttg  4140
tgcacagtc  ttttttttt  cttgtaatt  aaacaggcc  ggcattgtt  gttctattt  4200
atggacacg  gataatgtt  gaggtttta  agtgattaa  cgtgcagac  atgcaaacc  4259



<210> 9610
<211> 793
<212> PRT
<213> Rattus norvegicus
<308> P23377
<400> 9610

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Ala Gly Ala 
  1               5                  10                  15
Leu Val Leu Leu Ala Ala Glu Ala Arg Gly Gln Lys Ile Phe Thr Asn 
             20                  25                  30
Thr Trp Ala Val His Ile Ser Gly Gly Pro Ala Val Ala Asp Ser Val 
         35                  40                  45
Ala Arg Lys His Gly Phe His Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
     50                  55                  60
Tyr His Phe Trp His Arg Ala Val Thr Lys Arg Ser Leu Ser Pro His 
 65                  70                  75                  80
Arg Pro Arg His Ser Arg Leu Gln Arg Val Pro Gln Val Lys Trp Leu 
                 85                  90                  95
Glu Gln Gln Val Ala Lys Gln Arg Ala Lys Arg Asp Val Tyr Gln Glu 
             100                105                110
Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
         115                120                125
Gln Arg Asp Leu Asn Val Lys Glu Ala Trp Ala Gln Gly Phe Thr Gly 
     130                135                140
Arg Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
 145                150                155                160
Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                 165                170                175
Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
             180                185                190
Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
         195                200                205
Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
     210                215                220
Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
 225                230                235                240
Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                 245                250                255
Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
             260                265                270
Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
         275                280                285
Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
     290                295                300
Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
 305                310                315                320
Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                 325                330                335
Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
             340                345                350
Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
         355                360                365
Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
     370                375                380
Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
 385                390                395                400
Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                 405                410                415
Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
             420                425                430
Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
         435                440                445
Lys Cys Ile Ile Glu Ile Leu Ala Glu Pro Lys Asp Ile Gly Lys Arg 
     450                455                460
Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
 465                470                475                480
Ile Ser Arg Leu Glu His Val Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                 485                490                495
Arg Arg Gly Asp Leu Ala Ile His Leu Ile Ser Pro Met Gly Thr Arg 
             500                505                510
Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
         515                520                525
Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
     530                535                540
Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
 545                550                555                560
Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Ser Glu 
                 565                570                575
Gly Leu Ser Ala Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
             580                585                590
Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
         595                600                605
Ser Cys Val Gln Arg Cys Pro Pro Gly Phe Thr Pro Gln Val Leu Asp 
     610                615                620
Thr His Tyr Ser Thr Glu Asn Asp Val Glu Ile Ile Arg Ala Ser Val 
 625                630                635                640
Cys Thr Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Pro 
                 645                650                655
Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
             660                665                670
Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Arg Pro Gln 
         675                680                685
Gln Pro Pro Pro Ala Leu Arg Pro Glu Val Glu Val Glu Pro Arg Leu 
     690                695                700
Arg Ala Gly Leu Ala Ser His Leu Pro Glu Val Leu Ala Gly Leu Ser 
 705                710                715                720
Cys Leu Ile Ile Ala Leu Ile Phe Gly Ile Val Phe Leu Phe Leu His 
                 725                730                735
Arg Cys Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met Asp 
             740                745                750
Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln Glu 
         755                760                765
Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg Thr 
     770                775                780
Ala Phe Ile Lys Asp Gln Ser Ala Leu 
 785                790



<210> 9611
<211> 4180
<212> DNA
<213> Homo sapiens
<308> X17094
<400> 9611

gcggggaag  agcagcggc  aggatgaat  ccaggtgct  tggagctgg  tggtgaagg  60
cggcactct  caccctccc  agccctgcc  gtctcggcc  catgccccc  ccagtcagc  120
ccgggccac  ggcagtgag  aggcacctg  gagccgagg  cctatgacc  ggccaagga  180
acgggcgct  cagggtccc  gccacctgt  ccccccatg  agctgaggc  ctggttgct  240
tgggtggta  cagcaacag  aaccttggt  ctgctagca  ctgatgctc  gggccagaa  300
gtcttcacc  acacgtggg  tgtgcgcat  cctggaggc  cagcggtgg  caacagtgt  360
gcacggaag  atgggttcc  caacctggg  cagatcttc  gggactatt  ccacttctg  420
catcgagga  tgacgaagc  gtccctgtc  cctcaccgc  cgcggcaca  ccggctgca  480
agggagcct  aagtacagt  gctggaaca  caggtggca  agcgacgga  taaacggga  540
gtgtaccag  agcccacag  ccccaagtt  cctcagcag  ggtacctgt  tggtgtcac  600
cagcgggac  tgaatgtga  ggcggcctg  gcgcagggc  acacagggc  cggcattgt  660
gtctccatt  tggacgatg  catcgagaa  aaccacccg  acttggcag  caattatga  720
cctggggcc  gttttgatg  caatgacca  gaccctgac  cccagcctc  gtacacaca  780
atgaatgac  acaggcacg  cacacggtg  gcgggggaa  tggctgcgg  ggccaacaa  840
ggtgtctgt  gtgtaggtg  ggcctacaa  gcccgcatt  gaggggtgc  catgctgga  900
ggcgaggtg  cagatgcag  ggaggcacg  tcgctgggc  tgaacccca  ccacatcca  960
atctacagt  ccagctggg  ccccgagga  gacggcaag  cagtggatg  gccagcccg  1020
ctcgccgag  aggccttct  ccgtggggt  agccagggc  gaggggggc  gggctccat  1080
tttgtctgg  cctcgggga  cgggggccg  gaacatgac  gctgcaact  cgacggcta  1140
accaacagt  tctacacgc  gtccatcag  agcgccacg  agtttggca  cgtgccgtg  1200
tacagcgag  cctgctcgt  cacactggc  acgacctac  gcagtggca  ccagaatga  1260
aagcagatc  tgacgactg  cttgcggca  aagtgcacg  agtctcaca  gggcacctc  1320
gcctctgcc  ccttagcag  cggcatcat  gctctcacc  tggaggcca  taagaacct  1380
acatggcgg  acatgcaac  cctggtggt  cagacctcg  agccagccc  cctcaatgc  1440
aacgactgg  ccaccaatg  tgtgggccg  aaagtgagc  actcatatg  ctacgggct  1500
ttggacgca  gcgccatgg  ggccctggc  cagaattgg  ccacagtgg  cccccagcg  1560
aagtgcatc  tcgacatcc  caccgagcc  aaagacatc  ggaaacggc  cgaggtgcg  1620
aagaccgtg  ccgcgtgcc  gggcgagcc  aaccacatc  ctcggctgg  gcacgctca  1680
gcgcggctc  ccctgtcct  taatcgccg  ggcgacctg  ccatccacc  ggtcagccc  1740
atgggcacc  gctccaccc  gctggcagc  aggccacat  actactccg  agatgggtt  1800
aatgactgg  ccttcatga  aactcattc  tgggatgag  atccctctg  cgagtgggt  1860
ctagagatt  aaaacacca  cgaagccaa  aactatggg  cgctgacca  gttcaccct  1920
gtactctat  gcaccgccc  tgaggggct  cccgtacct  cagaaagca  tggctgcaa  1980
accctcacg  ccagtcagg  ctgtgtggt  tgcgaggaa  gcttctccc  gcaccagaa  2040
agctgtgtc  agcactgcc  tccaggctt  gccccccaa  tcctcgata  gcactatag  2100
accgagaat  acgtggaga  catccgggc  agcgtctgc  ccccctgcc  cgcctcatg  2160
gccacatgc  aggggccgg  cctgacaga  tgcctcagc  gccccagcc  cgcctcctt  2220
gaccctgtg  agcagactt  ctcccggca  agccagagc  gccgagagt  cccgccaca  2280
cagcagcca  ctcggctgc  cccggaggt  gaggcgggg  aacggctgc  ggcagggct  2340
ctgccctca  acctgcctg  ggtggtggc  ggcctcagc  gcgccttca  cgtgctggt  2400
ttcgtcact  tcttcctgg  cctgcagct  cgctctggc  ttagttttc  gggggtgaa  2460
gtgtacacc  tggaccgtg  cctcatctc  tacaagggg  tgccccctg  agcctggca  2520
gaggagtgc  cgtctgact  agaagagga  gagggccgg  gcgagagga  cgcctttat  2580
aaagaccag  gcgccctct  atgagccca  tgcccaccc  ctcaagcca  tcccctcct  2640
gggcacttt  taattcacc  aagtatttt  ttatcttgg  actgggttt  gaccccagc  2700
gggaggcaa  aggggtgga  actgtttcc  atcctaccc  cgggcccac  tggccacct  2760
aggtgggcc  aggaccagc  ggggcgtgg  gagggccgt  ccccaccct  agcacccct  2820
ccatgtgga  aaaggagtg  aacctttag  gcagcttgc  ccggccccg  ccccagcca  2880
agttcctgc  gagtgaaga  gggcagccc  tgcttgttg  gattcctga  ccaggccgc  2940
gctcttgcc  ttccctgtc  ctctaaagc  ataatggtc  catccaggc  gtcgggggc  3000
ggcctagga  atatctgag  gaggaggcc  cctctccaa  ggcttctgc  ccctccacc  3060
tgtccccca  ctctggtga  tcttggcgg  agcagccat  ataggaagg  accaaggca  3120
ggcaggtgc  tccaggtgt  cacgtggca  gtggcctgt  gcctgtgtc  catgaccca  3180
ccctgtgct  cgtgcctcc  ccaccactg  ccaccaggc  ggcgcagcc  aggccgaag  3240
tctggctga  ccctgtgct  gtgtcctga  caccctccc  tctcttgca  ccgcctctc  3300
cgtcagggc  caagtccct  ttttctgag  ccgggctgc  tgggctgtt  gcactcaca  3360
acctggagc  cctgggtgg  tggtgggga  gggcgctgg  ccagccggc  tctctggcc  3420
cccacccga  gctgctttc  cctgtgggg  tctcagggg  tgtttgagg  tatattttc  3480
ctttgtgat  atttcactt  agatgctga  gatttgttt  tgtattttt  atgggggta  3540
cagctggac  acccacgtt  tcacaccca  cgtccgccc  gctcctccc  ggctgccct  3600
gccctgagg  gtgggggct  cagcatgtt  ctgaggagt  aggaatagt  gagccccaa  3660
tcctgaaga  gcgggccag  caggcgggc  caaggaaag  gggtcccag  gggaggggc  3720
ggctgacat  tgtgtttca  gtggggctc  ccatgccgg  ggttcatag  tcactggct  3780
tccaagtgc  agaggtggg  aggtggtgg  actgagccc  cccaacact  tgccctggt  3840
gagaaagca  tgacctgtc  tgcccccct  aaacctcct  ttctgacgt  ccttttgca  3900
ccctcccat  aggacaatc  gtcccctcc  atctgggag  ccccttttc  tttctaccc  3960
agccattcc  ggtacccag  catctgccc  ggggtgccc  ctcctctcc  atccccctg  4020
cctcgtggc  agcccggct  gttttgtaa  atactgggt  ggtgcacag  gattttttt  4080
ttgtaattt  aacaggccc  gcattgctg  ttctattta  tggacatga  ataatgtta  4140
aggttttaa  gtgattaaa  gtgcagact  tgcaaaccag  4180



<210> 9612
<211> 794
<212> PRT
<213> Homo sapiens
<308> P09958
<400> 9612

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
  1               5                  10                  15
Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
             20                  25                  30
Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
         35                  40                  45
Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
     50                  55                  60
Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
 65                  70                  75                  80
Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                 85                  90                  95
Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
             100                105                110
Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
         115                120                125
Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
     130                135                140
His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
 145                150                155                160
Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                 165                170                175
Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
             180                185                190
Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
         195                200                205
Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
     210                215                220
Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
 225                230                235                240
Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                 245                250                255
Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
             260                265                270
Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
         275                280                285
Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
     290                295                300
Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
 305                310                315                320
Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                 325                330                335
Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
             340                345                350
Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
         355                360                365
Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
     370                375                380
Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
 385                390                395                400
Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                 405                410                415
Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
             420                425                430
Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
         435                440                445
Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
     450                455                460
Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
 465                470                475                480
Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                 485                490                495
Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
             500                505                510
Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
         515                520                525
Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
     530                535                540
Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
 545                550                555                560
Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                 565                570                575
Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
             580                585                590
Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
         595                600                605
Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
     610                615                620
Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
 625                630                635                640
Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                 645                650                655
Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
             660                665                670
Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
         675                680                685
Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
     690                695                700
Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
 705                710                715                720
Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                 725                730                735
Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
             740                745                750
Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
         755                760                765
Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
     770                775                780
Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
 785                790



<210> 9613
<211> 4259
<212> DNA
<213> Rattus norvegicus
<308> X55660
<400> 9613

aaaaaagag  attccgtgg  ttaaaaaaa  agtttgaaa  cctctgact  aatagtttc  60
accaccaag  aaactgagg  ccagagaga  gaaatgacc  gggtaagat  tccgaggga  120
cagtagttg  acagggact  ggagttaaa  tttcatggg  ggtgcctgt  acaggacct  180
ccttggggt  tctgctgga  agagagacc  gattgggtt  cccagcagt  ttcagtggc  240
tgctccgtg  ctgcctcag  caggtctcc  gcagccaca  ctggggatc  ggcccccgt  300
ctgtcctcc  gccccaccc  cctcggctc  atgcccccc  cagtcagct  cgggaccct  360
gcagtgagc  ggcacgtgg  agccaaggc  ctgtgacca  gccagggag  cggagctct  420
gggtcccag  cacctgccc  cccatggag  tgagaccct  gttgctatg  gtggtagca  480
cagcaggag  cttggtcct  ctagcagct  aagctcgcg  ccagaagat  ttcaccaac  540
cgtgggctg  gcacatttc  ggaggccca  ctgtggctg  tagtgtggc  cggaagcat  600
ggttccaca  cctgggcca  atcttcggt  actattacc  cttctggca  agagcagtg  660
caaagcggt  cctgtcgcc  caccgcccg  ggcacagcc  gctacagag  gtgcctcaa  720
tgaagtggc  ggagcagca  gtagccaag  aaagggcca  gagggacgt  tatcaggag  780
ccacagacc  caagttccc  cagcagtgg  acctgtctg  ggtcactca  cgagacctg  840
atgtgaagg  agcctgggc  cagggcttc  cagggcgtg  cattgtggt  tccatcctg  900
atgacggca  tgaaaagaa  catcctgac  tggcaggca  ttatgaccc  ggagccagc  960
ttgatgtca  tgaccagga  cctgaccca  agcctcggt  cacgcagat  aatgacaac  1020
ggcacggca  tcggtgtgc  ggggaagtg  cagcggtgg  caacaatgg  gtctgtggt  1080
taggtgtag  ttacaatgc  cggattgga  gggtgcgta  gttggatgg  gaggtgact  1140
acgcggtag  ggcacgttc  ctgggcctg  atcccaacc  catccacat  tacagcgcc  1200
gctggggcc  cgaggacga  ggcaagacc  tggatgggc  agcccggct  gccgaggag  1260
ccttctttc  gggagttag  cagggccgc  gagggctgg  ctccatctt  gtctgggcc  1320
cagggaatg  gggccggga  catgacagc  gtaactgtg  cggctacac  aacagtatc  1380
acacgctgt  catcagcag  gccacacaa  tcggcaacg  gccctggta  agtgaggcc  1440
gctcctcca  actggccac  acctacagc  gtggcaacc  gaatgagaa  cagattgtg  1500
caactgact  gaggcagaa  tgcactgag  ctcacacag  cacctcagc  tccgcccct  1560
tggcagctg  tatcattgc  ctcaccctg  aggccaaca  gaacctcac  tggcgggac  1620
tgcagcacc  ggtggtgca  acctcaaag  cagcacatc  caacgctaa  gattgggcc  1680
ccaatggcg  gggccggaa  gtgagccat  cctatggct  cgggctgtt  gatgcaggt  1740
ccatggtgg  cctggccca  aactggaca  cagtggccc  ccagcggaa  tgcatcatt  1800
aaatcctgg  agagcccaa  gacattggc  aacggctag  ggtgcgcaa  accgtgaca  1860
cgtgcctgg  tgagcccaa  cacatctcc  gactggaac  cgttcaggc  cggctcacc  1920
tgtcttaca  tcgccgtgg  gacctggct  tccacctca  cagccccat  ggcacccgt  1980
ccaccctat  agctgccag  ccacatgac  actctgctg  tggatttaa  gactgggct  2040
tcatgacaa  tcattcctg  gatgaggac  cctctggcg  gtgggtcct  gagattgaa  2100
ataccagcg  ggccaacaa  tatgggacg  tgaccaagt  cactctcgt  ctatatggc  2160
cagcctctg  gggtctctc  gcacctcca  agagcagcg  ctgcaagac  ctcacatcc  2220
gccaggcct  cgtggtgtg  gaggaaggt  tctcactgc  ccagaaaag  tgtgtccag  2280
gttgcccac  aggcttcac  ccccaagtc  ttgatacac  ctacagcac  gagaatgat  2340
tggagatca  ccgtgccag  gtctgcacc  cctgccacg  ctcatgtgc  acttgccag  2400
gcccagctc  cacagactg  ctcagctgc  ccagccatg  ctccctgga  cctgtggag  2460
aaacctgct  ccggcaaag  cagagcagc  gagagtccc  acctcagca  ccacctccc  2520
cactgcgcc  agaggtgga  gtggagccc  ggttgcggg  tgggctggc  tctcacctg  2580
cggaggtcc  ggccggcct  agctgcctt  tcatcgctc  catctttgg  atcgtcttc  2640
tcttcctgc  tcggtgttc  ggcttcagc  tccggggag  gaaagtgta  accatggac  2700
gtggcctca  ctcctacaa  gggctgcct  ctgaggcct  gcaggagga  tgcccatct  2760
actcagaag  ggatgaggg  cggggcgag  ggaccgcct  tatcaaaga  cagagcgcc  2820
tttgatgag  ccactgccc  ccctatcaa  tcgatccct  cctcggcac  ttttaattc  2880
ccaaagtat  tttttatct  gggactggg  ttggaccct  gctgggagg  gagaggggc  2940
gagaccctt  ggcctacct  tttgcctga  gtggggtcc  gggagcctc  ccccccacc  3000
accctccat  tggaggaag  agtaaatct  tagggcagc  tcctgcaga  tgaagaggg  3060
cagcctttc  gactccctg  ccagctgca  ccttgcccc  cccctgccc  tcagaaagc  3120
ataatggtc  ccatccagg  aacagggag  ctggccagg  ggtacttga  gaaggtggc  3180
acctctcca  gggcttttg  atcccctga  cctctctgg  tcaggatga  cctctgaag  3240
agcttgcag  cacaggaag  gaccaaagc  aacgaggca  tctccagtg  gcctgcact  3300
ttgctctca  cctgcctct  cactccagg  ctccacctc  gctggtagc  aggctgagc  3360
agacctgca  aggtcaggc  ctggggcct  atgctggtg  cctgaccat  ctctatggc  3420
ccccccccc  aagccaggg  cttgttttc  gagcccggg  ctgcctggg  agttggcgc  3480
cacagtcca  gagcccctg  gtgggtggt  gggagggac  gtggctcct  ccacctccc  3540
cccgatgct  ctttcccct  tggggatct  aggagctgt  tgaggatat  ttttcactt  3600
gtgattatt  actttagat  ctgattttt  tttttttgt  tttttaatg  gggtagcag  3660
tggaccatt  accttctcc  acccatgtc  accctgcct  tcccatggc  gcccagctc  3720
gaggcagag  gaatcacta  gccccaagt  ctgaagagg  aggccagcc  gctgggctc  3780
aggaaaggg  gtcatggtg  gaggggtag  ctgacatca  ctgtttcaa  tggggttgt  3840
ccacaggct  ttgggttgc  ggctctcca  gtgccaggg  tgggcaggt  gcaccacca  3900
gcccaaact  acactgtgc  ctggtggag  aagcattgg  ctatgatgc  ccccaaacc  3960
cctgttctg  tgtgccttt  gcacccctc  cattaggac  atcagtccc  tcccacttg  4020
gcctcctct  ttctttttc  tagcccttc  cggtaccca  cctacctgt  cagggtgcc  4080
cttgctctc  tgcccaccc  tagcggcca  ccaggctgg  tttgtaaga  gctgggttg  4140
tgcacagtc  ttttttttt  cttgtaatt  aaacaggcc  ggcattgtt  gttctattt  4200
atggacacg  gataatgtt  gaggtttta  agtgattaa  cgtgcagac  atgcaaacc  4259



<210> 9614
<211> 793
<212> PRT
<213> Rattus norvegicus
<308> P23377
<400> 9614

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Ala Gly Ala 
  1               5                  10                  15
Leu Val Leu Leu Ala Ala Glu Ala Arg Gly Gln Lys Ile Phe Thr Asn 
             20                  25                  30
Thr Trp Ala Val His Ile Ser Gly Gly Pro Ala Val Ala Asp Ser Val 
         35                  40                  45
Ala Arg Lys His Gly Phe His Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
     50                  55                  60
Tyr His Phe Trp His Arg Ala Val Thr Lys Arg Ser Leu Ser Pro His 
 65                  70                  75                  80
Arg Pro Arg His Ser Arg Leu Gln Arg Val Pro Gln Val Lys Trp Leu 
                 85                  90                  95
Glu Gln Gln Val Ala Lys Gln Arg Ala Lys Arg Asp Val Tyr Gln Glu 
             100                105                110
Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
         115                120                125
Gln Arg Asp Leu Asn Val Lys Glu Ala Trp Ala Gln Gly Phe Thr Gly 
     130                135                140
Arg Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
 145                150                155                160
Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                 165                170                175
Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
             180                185                190
Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
         195                200                205
Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
     210                215                220
Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
 225                230                235                240
Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                 245                250                255
Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
             260                265                270
Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
         275                280                285
Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
     290                295                300
Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
 305                310                315                320
Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                 325                330                335
Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
             340                345                350
Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
         355                360                365
Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
     370                375                380
Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
 385                390                395                400
Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                 405                410                415
Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
             420                425                430
Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
         435                440                445
Lys Cys Ile Ile Glu Ile Leu Ala Glu Pro Lys Asp Ile Gly Lys Arg 
     450                455                460
Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
 465                470                475                480
Ile Ser Arg Leu Glu His Val Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                 485                490                495
Arg Arg Gly Asp Leu Ala Ile His Leu Ile Ser Pro Met Gly Thr Arg 
             500                505                510
Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
         515                520                525
Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
     530                535                540
Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
 545                550                555                560
Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Ser Glu 
                 565                570                575
Gly Leu Ser Ala Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
             580                585                590
Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
         595                600                605
Ser Cys Val Gln Arg Cys Pro Pro Gly Phe Thr Pro Gln Val Leu Asp 
     610                615                620
Thr His Tyr Ser Thr Glu Asn Asp Val Glu Ile Ile Arg Ala Ser Val 
 625                630                635                640
Cys Thr Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Pro 
                 645                650                655
Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
             660                665                670
Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Arg Pro Gln 
         675                680                685
Gln Pro Pro Pro Ala Leu Arg Pro Glu Val Glu Val Glu Pro Arg Leu 
     690                695                700
Arg Ala Gly Leu Ala Ser His Leu Pro Glu Val Leu Ala Gly Leu Ser 
 705                710                715                720
Cys Leu Ile Ile Ala Leu Ile Phe Gly Ile Val Phe Leu Phe Leu His 
                 725                730                735
Arg Cys Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met Asp 
             740                745                750
Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln Glu 
         755                760                765
Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg Thr 
     770                775                780
Ala Phe Ile Lys Asp Gln Ser Ala Leu 
 785                790



<210> 9615
<211> 4180
<212> DNA
<213> Homo sapiens
<308> X17094
<400> 9615

gcggggaag  agcagcggc  aggatgaat  ccaggtgct  tggagctgg  tggtgaagg  60
cggcactct  caccctccc  agccctgcc  gtctcggcc  catgccccc  ccagtcagc  120
ccgggccac  ggcagtgag  aggcacctg  gagccgagg  cctatgacc  ggccaagga  180
acgggcgct  cagggtccc  gccacctgt  ccccccatg  agctgaggc  ctggttgct  240
tgggtggta  cagcaacag  aaccttggt  ctgctagca  ctgatgctc  gggccagaa  300
gtcttcacc  acacgtggg  tgtgcgcat  cctggaggc  cagcggtgg  caacagtgt  360
gcacggaag  atgggttcc  caacctggg  cagatcttc  gggactatt  ccacttctg  420
catcgagga  tgacgaagc  gtccctgtc  cctcaccgc  cgcggcaca  ccggctgca  480
agggagcct  aagtacagt  gctggaaca  caggtggca  agcgacgga  taaacggga  540
gtgtaccag  agcccacag  ccccaagtt  cctcagcag  ggtacctgt  tggtgtcac  600
cagcgggac  tgaatgtga  ggcggcctg  gcgcagggc  acacagggc  cggcattgt  660
gtctccatt  tggacgatg  catcgagaa  aaccacccg  acttggcag  caattatga  720
cctggggcc  gttttgatg  caatgacca  gaccctgac  cccagcctc  gtacacaca  780
atgaatgac  acaggcacg  cacacggtg  gcgggggaa  tggctgcgg  ggccaacaa  840
ggtgtctgt  gtgtaggtg  ggcctacaa  gcccgcatt  gaggggtgc  catgctgga  900
ggcgaggtg  cagatgcag  ggaggcacg  tcgctgggc  tgaacccca  ccacatcca  960
atctacagt  ccagctggg  ccccgagga  gacggcaag  cagtggatg  gccagcccg  1020
ctcgccgag  aggccttct  ccgtggggt  agccagggc  gaggggggc  gggctccat  1080
tttgtctgg  cctcgggga  cgggggccg  gaacatgac  gctgcaact  cgacggcta  1140
accaacagt  tctacacgc  gtccatcag  agcgccacg  agtttggca  cgtgccgtg  1200
tacagcgag  cctgctcgt  cacactggc  acgacctac  gcagtggca  ccagaatga  1260
aagcagatc  tgacgactg  cttgcggca  aagtgcacg  agtctcaca  gggcacctc  1320
gcctctgcc  ccttagcag  cggcatcat  gctctcacc  tggaggcca  taagaacct  1380
acatggcgg  acatgcaac  cctggtggt  cagacctcg  agccagccc  cctcaatgc  1440
aacgactgg  ccaccaatg  tgtgggccg  aaagtgagc  actcatatg  ctacgggct  1500
ttggacgca  gcgccatgg  ggccctggc  cagaattgg  ccacagtgg  cccccagcg  1560
aagtgcatc  tcgacatcc  caccgagcc  aaagacatc  ggaaacggc  cgaggtgcg  1620
aagaccgtg  ccgcgtgcc  gggcgagcc  aaccacatc  ctcggctgg  gcacgctca  1680
gcgcggctc  ccctgtcct  taatcgccg  ggcgacctg  ccatccacc  ggtcagccc  1740
atgggcacc  gctccaccc  gctggcagc  aggccacat  actactccg  agatgggtt  1800
aatgactgg  ccttcatga  aactcattc  tgggatgag  atccctctg  cgagtgggt  1860
ctagagatt  aaaacacca  cgaagccaa  aactatggg  cgctgacca  gttcaccct  1920
gtactctat  gcaccgccc  tgaggggct  cccgtacct  cagaaagca  tggctgcaa  1980
accctcacg  ccagtcagg  ctgtgtggt  tgcgaggaa  gcttctccc  gcaccagaa  2040
agctgtgtc  agcactgcc  tccaggctt  gccccccaa  tcctcgata  gcactatag  2100
accgagaat  acgtggaga  catccgggc  agcgtctgc  ccccctgcc  cgcctcatg  2160
gccacatgc  aggggccgg  cctgacaga  tgcctcagc  gccccagcc  cgcctcctt  2220
gaccctgtg  agcagactt  ctcccggca  agccagagc  gccgagagt  cccgccaca  2280
cagcagcca  ctcggctgc  cccggaggt  gaggcgggg  aacggctgc  ggcagggct  2340
ctgccctca  acctgcctg  ggtggtggc  ggcctcagc  gcgccttca  cgtgctggt  2400
ttcgtcact  tcttcctgg  cctgcagct  cgctctggc  ttagttttc  gggggtgaa  2460
gtgtacacc  tggaccgtg  cctcatctc  tacaagggg  tgccccctg  agcctggca  2520
gaggagtgc  cgtctgact  agaagagga  gagggccgg  gcgagagga  cgcctttat  2580
aaagaccag  gcgccctct  atgagccca  tgcccaccc  ctcaagcca  tcccctcct  2640
gggcacttt  taattcacc  aagtatttt  ttatcttgg  actgggttt  gaccccagc  2700
gggaggcaa  aggggtgga  actgtttcc  atcctaccc  cgggcccac  tggccacct  2760
aggtgggcc  aggaccagc  ggggcgtgg  gagggccgt  ccccaccct  agcacccct  2820
ccatgtgga  aaaggagtg  aacctttag  gcagcttgc  ccggccccg  ccccagcca  2880
agttcctgc  gagtgaaga  gggcagccc  tgcttgttg  gattcctga  ccaggccgc  2940
gctcttgcc  ttccctgtc  ctctaaagc  ataatggtc  catccaggc  gtcgggggc  3000
ggcctagga  atatctgag  gaggaggcc  cctctccaa  ggcttctgc  ccctccacc  3060
tgtccccca  ctctggtga  tcttggcgg  agcagccat  ataggaagg  accaaggca  3120
ggcaggtgc  tccaggtgt  cacgtggca  gtggcctgt  gcctgtgtc  catgaccca  3180
ccctgtgct  cgtgcctcc  ccaccactg  ccaccaggc  ggcgcagcc  aggccgaag  3240
tctggctga  ccctgtgct  gtgtcctga  caccctccc  tctcttgca  ccgcctctc  3300
cgtcagggc  caagtccct  ttttctgag  ccgggctgc  tgggctgtt  gcactcaca  3360
acctggagc  cctgggtgg  tggtgggga  gggcgctgg  ccagccggc  tctctggcc  3420
cccacccga  gctgctttc  cctgtgggg  tctcagggg  tgtttgagg  tatattttc  3480
ctttgtgat  atttcactt  agatgctga  gatttgttt  tgtattttt  atgggggta  3540
cagctggac  acccacgtt  tcacaccca  cgtccgccc  gctcctccc  ggctgccct  3600
gccctgagg  gtgggggct  cagcatgtt  ctgaggagt  aggaatagt  gagccccaa  3660
tcctgaaga  gcgggccag  caggcgggc  caaggaaag  gggtcccag  gggaggggc  3720
ggctgacat  tgtgtttca  gtggggctc  ccatgccgg  ggttcatag  tcactggct  3780
tccaagtgc  agaggtggg  aggtggtgg  actgagccc  cccaacact  tgccctggt  3840
gagaaagca  tgacctgtc  tgcccccct  aaacctcct  ttctgacgt  ccttttgca  3900
ccctcccat  aggacaatc  gtcccctcc  atctgggag  ccccttttc  tttctaccc  3960
agccattcc  ggtacccag  catctgccc  ggggtgccc  ctcctctcc  atccccctg  4020
cctcgtggc  agcccggct  gttttgtaa  atactgggt  ggtgcacag  gattttttt  4080
ttgtaattt  aacaggccc  gcattgctg  ttctattta  tggacatga  ataatgtta  4140
aggttttaa  gtgattaaa  gtgcagact  tgcaaaccag  4180



<210> 9616
<211> 794
<212> PRT
<213> Homo sapiens
<308> P09958
<400> 9616

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
  1               5                  10                  15
Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
             20                  25                  30
Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
         35                  40                  45
Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
     50                  55                  60
Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
 65                  70                  75                  80
Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                 85                  90                  95
Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
             100                105                110
Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
         115                120                125
Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
     130                135                140
His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
 145                150                155                160
Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                 165                170                175
Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
             180                185                190
Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
         195                200                205
Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
     210                215                220
Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
 225                230                235                240
Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                 245                250                255
Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
             260                265                270
Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
         275                280                285
Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
     290                295                300
Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
 305                310                315                320
Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                 325                330                335
Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
             340                345                350
Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
         355                360                365
Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
     370                375                380
Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
 385                390                395                400
Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                 405                410                415
Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
             420                425                430
Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
         435                440                445
Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
     450                455                460
Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
 465                470                475                480
Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                 485                490                495
Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
             500                505                510
Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
         515                520                525
Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
     530                535                540
Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
 545                550                555                560
Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                 565                570                575
Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
             580                585                590
Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
         595                600                605
Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
     610                615                620
Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
 625                630                635                640
Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                 645                650                655
Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
             660                665                670
Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
         675                680                685
Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
     690                695                700
Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
 705                710                715                720
Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                 725                730                735
Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
             740                745                750
Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
         755                760                765
Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
     770                775                780
Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
 785                790



<210> 9617
<211> 1066
<212> DNA
<213> Rattus norvegicus
<308> X56133
<400> 9617

gtggctgac  gccagatgt  tctgctgct  cgccgaccc  cgggtcgag  ggcctatcc  60
ggtgatgtg  tttacctac  ctctcgcct  ctggagaga  cagccaaga  gaacgattc  120
tttggtggt  gctctttga  tgccttacc  gtcattgaa  cacaggctg  tgatgtgtc  180
gcctacatt  caacaaacg  tatttccat  accgatgga  agatcttct  ggaaacaga  240
ttgttctat  aaggcatcc  ccctgccat  aatgtgggc  tgtctgtgt  ccgtgtcgg  300
tctgccgcc  agaccagag  catgaagca  gtggcaggc  ccatgaagc  ggagttggc  360
cagtaccgg  aggtcgctg  ttttgccca  tttggttct  atctggatg  tgccactca  420
cagctcttg  gccgtggcg  gcgcctgac  gagctgcta  agcaaggac  gtactctcc  480
atggctatt  aagaacagg  ggctgtcat  tatgcaggc  tccggggtt  tcttgataa  540
ctggagccc  gtaagatca  aaagttcga  agtgctttc  tgtctcatg  tgtgagcca  600
caccagagc  tcttgggca  tatcaggtc  gatgggaaa  tctcagaac  gtcggatgc  660
aagctgaag  aaatcgtaa  aaacttctt  gctgggttt  aaccttaaa  ccctgccac  720
gtcaccaga  actgctttg  ttttgtcat  tattgtggt  aaatcagca  catttgtaa  780
ggtttactc  tgtactccc  gatgtacag  aatcacatg  ataaaagtt  catattgag  840
gctagtttg  gtgggacgg  ctcagatgt  tcctgggac  tgtggaggt  agagagcag  900
ctgtaggag  cagtgccct  ctttccctg  gaatttaac  caggttatt  tttaaagct  960
gacttcagg  gttggggat  tagctcagt  gtagagcgc  tgcctagga  gcgcaaggc  1020
ctgggttcg  tccccagct  cggaaaaaa  agaaccaac  cgaatt  1066



<210> 9618
<211> 543
<212> PRT
<213> Rattus norvegicus
<308> P15999
<400> 9618

Arg Arg Ala Leu Pro Arg Arg Ala Gly Leu Val Ser Lys Asn Ala Leu 
  1               5                  10                  15
Gly Ser Ser Phe Val Gly Thr Arg Asn Leu His Ala Ser Asn Thr Arg 
             20                  25                  30
Leu Gln Lys Thr Gly Thr Ala Glu Met Ser Ser Ile Leu Glu Glu Arg 
         35                  40                  45
Ile Leu Gly Ala Asp Thr Ser Val Asp Leu Glu Glu Thr Gly Arg Val 
     50                  55                  60
Leu Ser Ile Gly Asp Gly Ile Ala Arg Val His Gly Leu Arg Asn Val 
 65                  70                  75                  80
Gln Ala Glu Glu Met Val Glu Phe Ser Ser Gly Leu Lys Gly Met Ser 
                 85                  90                  95
Leu Asn Leu Glu Pro Asp Asn Val Gly Val Val Val Phe Gly Asn Asp 
             100                105                110
Lys Leu Ile Lys Glu Gly Asp Ile Val Lys Arg Thr Gly Ala Ile Val 
         115                120                125
Asp Val Pro Val Gly Asp Glu Leu Leu Gly Arg Val Val Asp Ala Leu 
     130                135                140
Gly Asn Ala Ile Asp Gly Lys Gly Pro Val Gly Ser Lys Ile Arg Arg 
 145                150                155                160
Arg Val Gly Leu Lys Ala Pro Gly Ile Ile Pro Arg Ile Ser Val Arg 
                 165                170                175
Glu Pro Met Gln Thr Gly Ile Lys Ala Val Asp Ser Leu Val Pro Ile 
             180                185                190
Gly Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys 
         195                200                205
Thr Ser Ile Ala Ile Asp Thr Ile Ile Asn Gln Lys Arg Phe Asn Asp 
     210                215                220
Gly Thr Asp Glu Lys Lys Lys Leu Tyr Cys Ile Tyr Val Ala Ile Gly 
 225                230                235                240
Gln Lys Arg Ser Thr Val Ala Gln Leu Val Lys Arg Leu Thr Asp Ala 
                 245                250                255
Asp Ala Met Lys Tyr Thr Ile Val Val Ser Ala Thr Ala Ser Asp Ala 
             260                265                270
Ala Pro Leu Gln Tyr Leu Ala Pro Tyr Ser Gly Cys Ser Met Gly Glu 
         275                280                285
Tyr Phe Arg Asp Asn Gly Lys His Ala Leu Ile Ile Tyr Asp Asp Leu 
     290                295                300
Ser Lys Gln Ala Val Ala Tyr Arg Gln Met Ser Leu Leu Leu Arg Arg 
 305                310                315                320
Pro Pro Gly Arg Glu Ala Tyr Pro Gly Asp Val Phe Tyr Leu His Ser 
                 325                330                335
Arg Leu Leu Glu Arg Ala Ala Lys Met Asn Asp Ser Phe Gly Gly Gly 
             340                345                350
Ser Leu Thr Ala Leu Pro Val Ile Glu Thr Gln Ala Gly Asp Val Ser 
         355                360                365
Ala Tyr Ile Pro Thr Asn Val Ile Ser Ile Thr Asp Gly Gln Ile Phe 
     370                375                380
Leu Glu Thr Glu Leu Phe Tyr Lys Gly Ile Arg Pro Ala Ile Asn Val 
 385                390                395                400
Gly Leu Ser Val Ser Arg Val Gly Ser Ala Ala Gln Thr Arg Ala Met 
                 405                410                415
Lys Gln Val Ala Gly Thr Met Lys Leu Glu Leu Ala Gln Tyr Arg Glu 
             420                425                430
Val Ala Ala Phe Ala Gln Phe Gly Ser Asp Leu Asp Ala Ala Thr Gln 
         435                440                445
Gln Leu Leu Ser Arg Gly Val Arg Leu Thr Glu Leu Leu Lys Gln Gly 
     450                455                460
Gln Tyr Ser Pro Met Ala Ile Glu Glu Gln Val Ala Val Ile Tyr Ala 
 465                470                475                480
Gly Val Arg Gly Tyr Leu Asp Lys Leu Glu Pro Ser Lys Ile Thr Lys 
                 485                490                495
Phe Glu Ser Ala Phe Leu Ser His Val Val Ser Gln His Gln Ser Leu 
             500                505                510
Leu Gly Asn Ile Arg Ser Asp Gly Lys Ile Ser Glu Gln Ser Asp Ala 
         515                520                525
Lys Leu Lys Glu Ile Val Thr Asn Phe Leu Ala Gly Phe Glu Pro 
     530                535                540



<210> 9619
<211> 2725
<212> DNA
<213> Homo sapiens
<308> NM_004046
<400> 9619

ggcacgagg  gccttggca  gaggagtgt  gcccttcct  gaatccctc  ggacacacc  60
tcctagcat  ctctaggaa  gatgcggca  ctcaaaggg  agcccaaga  ggagacctc  120
aaggacaag  aggagcgga  gcaagccat  caggaggcc  ggcagcaga  cactacagt  180
gtgctgccc  cgctggccg  ggtcgtgct  ttgatcgtg  tgtttgtgt  cgtggccac  240
cgccccacc  tcaccgagt  agccccgca  ccggctgcg  accccatcg  cagggagag  300
aggcgcggg  gggggacgc  aacaaaaaa  ggctttcat  ttcagagat  ttcatgttg  360
tgagctgta  gcaggagca  cctgtcttc  ctggtcttt  acttgatta  agtatctcc  420
ctttcttgg  agggaatag  ggatgtttt  tcagtgaat  tgccataca  cttatggtc  480
acttcatgt  cctttcaga  ttcaaagcg  gcgcgcatg  gtgtgtgtg  gtgtgtgtg  540
gtgtgtgtg  gtgtgtgtg  ttctttttc  ctcctaaaa  tcgataagt  gctccacct  600
aagagggat  gaacctctg  gtcaggaaa  agctggaat  cacactcac  tcattccca  660
tgtttggat  atgcttctt  ccaacacgt  ttcacaatc  ccaaaggga  tgtatttct  720
ctctgtgct  aatgtgatt  gaaatatgt  gaatcaaag  gaaatattt  ttttttgaa  780
aaaggagat  atagcctta  aaaaaaaaa  aaaaaaaac  cgagactag  tctctctct  840
cctcgtgcc  aattcggca  gaggccgga  gctgcggct  cagaagtac  gcctgcgga  900
taactgcaa  gatgctgtc  gtgcgcgtt  ctgcggccg  ggtccgcgc  cttcctcgg  960
gggccggac  ggtctccag  aatgctttg  gttcatctt  cattgctgc  aggaacttc  1020
atgcctcta  cactcatct  caaaagact  ggactgctg  gatgtcctc  attcttgaa  1080
agcgtattc  tggagctga  acctctgtt  atcttgaag  aactgggcg  gtcttaagt  1140
ttggtgatg  tattgcccg  gtacatggg  tgaggaatg  tcaagcaga  gaaatggta  1200
agttttctt  aggcttaaa  ggtatgtcc  tgaacttgg  acctgacaa  gttggtgtt  1260
tcgtgtttg  aaatgataa  ctaattaag  aaggagata  agtgaagag  acaggagcc  1320
ttgtggacg  tccagttgg  gaggagctg  tgggtcgtg  agttgatgc  cttggtaat  1380
ctattgatg  aaagggtcc  attggttcc  agacgcgta  gcgagttgg  ctgaaagcc  1440
ccggtatca  tcctcgaat  tcagtgcgg  aaccaatgc  gactggcat  aaggctgtg  1500
atagcttgg  gccaattgg  cgtggtcag  gtgaactga  tattggtga  cgacagact  1560
ggaaaacct  aattgctat  gacacaatc  ttaaccaga  acgtttcaa  gatggatct  1620
atgaaaaga  gaagctgta  tgtatttat  ttgctattg  tcaaaagag  tccactgtt  1680
cccagttgg  gaagagact  acagatgca  atgccatga  gtacaccat  gtggtgtcg  1740
ctacggcct  ggatgctgc  ccacttcag  acctggctc  ttactctgg  tgttccatg  1800
gagagtatt  tagagacaa  ggcaaacat  ctttgatca  ctatgacga  ttatccaaa  1860
aggctgttg  ttaccgtca  atgtctctg  tgctccgcc  accccctgg  cgtgaggcc  1920
atcctggtg  tgtgttcta  ctacactcc  ggttgctgg  gagagcagc  aaaatgaac  1980
atgcttttg  tggtggctc  ttgactgct  tgccagtca  agaaacaca  gctggtgat  2040
tgtctgctt  cattccaac  aatgtcatt  ccatcactg  cggacagat  ttcttggaa  2100
cagaattgt  ctacaaagg  atccgccct  caattaacg  tggtctgtc  gtatctcgt  2160
tcggatccg  tgcccaaac  agggctatg  agcaggtag  aggtaccat  aagctggaa  2220
tggctcagt  tcgtgaggt  gctgctttt  cccagttcg  ttctgacct  gatgctgcc  2280
ctcaacaac  tttgagtcg  ggcgtgcgt  taactgagt  gctgaagca  ggacagtat  2340
ctcccatgg  tattgaaga  caagtggct  ttatctatg  gggtgtaag  ggatatctt  2400
ataaactgg  gcccagcaa  attacaaag  ttgagaatg  tttcttgtc  catgtcgtc  2460
gccagcacc  agccttgtt  ggcactatc  gggctgatg  aaagatctc  gaacaatca  2520
atgcaaagc  gaaagagat  gtaacaaat  tcttggctg  atttgaagc  taaactcct  2580
tggattcac  tcaaatacc  gttcagttt  gtcattgtt  tagtaaatt  gttccattt  2640
taaaagggt  actctcata  tccttatgt  cagaaatca  atgaaaaat  aaggttcca  2700
aatgcgtaa  aaaaaaaaa  aaaaa  2725



<210> 9620
<211> 553
<212> PRT
<213> Homo sapiens
<308> P25705
<400> 9620

Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
  1               5                  10                  15
Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
             20                  25                  30
Ala Arg Asn Phe His Ala Ser Asn Thr His Leu Gln Lys Thr Gly Thr 
         35                  40                  45
Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr 
     50                  55                  60
Ser Val Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly 
 65                  70                  75                  80
Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val 
                 85                  90                  95
Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp 
             100                105                110
Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly 
         115                120                125
Asp Ile Val Lys Arg Thr Gly Ala Ile Val Asp Val Pro Val Gly Glu 
     130                135                140
Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly 
 145                150                155                160
Lys Gly Pro Ile Gly Ser Lys Thr Arg Arg Arg Val Gly Leu Lys Ala 
                 165                170                175
Pro Gly Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Thr Gly 
             180                185                190
Ile Lys Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu 
         195                200                205
Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr Ser Ile Ala Ile Asp 
     210                215                220
Thr Ile Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys 
 225                230                235                240
Lys Leu Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Thr Val 
                 245                250                255
Ala Gln Leu Val Lys Arg Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr 
             260                265                270
Ile Val Val Ser Ala Thr Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu 
         275                280                285
Ala Pro Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly 
     290                295                300
Lys His Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala 
 305                310                315                320
Tyr Arg Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala 
                 325                330                335
Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala 
             340                345                350
Ala Lys Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro 
         355                360                365
Val Ile Glu Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn 
     370                375                380
Val Ile Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe 
 385                390                395                400
Tyr Lys Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg 
                 405                410                415
Val Gly Ser Ala Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr 
             420                425                430
Met Lys Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln 
         435                440                445
Phe Gly Ser Asp Leu Asp Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly 
     450                455                460
Val Arg Leu Thr Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala 
 465                470                475                480
Ile Glu Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu 
                 485                490                495
Asp Lys Leu Glu Pro Ser Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu 
             500                505                510
Ser His Val Val Ser Gln His Gln Ala Leu Leu Gly Thr Ile Arg Ala 
         515                520                525
Asp Gly Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val 
     530                535                540
Thr Asn Phe Leu Ala Gly Phe Glu Ala 
 545                550



<210> 9621
<211> 999
<212> DNA
<213> Rattus norvegicus
<308> X56228
<400> 9621

catcaggtg  tctaccgag  gctggtctc  accaagtgg  tggcggaat  cattcggtc  60
ggcaaggtg  ggccaagcc  tcgggtgct  gacgcgtca  ggtactcac  agggacccg  120
caggcacgc  aagagtacc  ggagcgaca  gtgcctggc  cgtccttct  tgatataga  180
gagtgccgg  acacgactt  gccttacga  atgatgctg  ccagtgagg  ccactttgg  240
gactacgtg  gcaacctgg  cataagcaa  gacacacac  tcgtggtat  cgatggaga  300
gacctgggc  gcttctatg  acccagagt  tggtggatg  ttcgtgtgt  tggccaccg  360
acagtatca  tgctcaatg  tggcttccg  aactggctg  aggagggcc  cccggtgac  420
tctgaaccc  cgcggccag  gccagccgt  ttcaaagcc  cactgaacc  ctccctgct  480
aagacctat  agcaggtcc  ggagaacct  cagtctaaa  ggttccagc  ggtggattc  540
cgggcccag  gacggtacc  gggcacaca  ccggagccc  atgcagtag  actggactc  600
ggccacatc  gtggctctg  caacgtgcc  ttcatgaac  tcctgacag  agatggctt  660
gagaagagc  cagaggagc  gcgtgccat  ttccaggac  agaaggtgg  cctctccca  720
ccccttatc  ccacatgcc  caaaggggt  actgcttgc  acattgccc  ggctgccta  780
ctttgtggc  agcccgatg  ggctgttta  gatggctcc  ggtcagagt  gtttcgcag  840
gcccccccg  agacccgtg  gtcccaggg  aagagtggg  aggcctgag  gtgtgcagc  900
tcctcttcc  cccaccaga  ccagccagt  cccttcagt  aggcttgta  gacctgctg  960
aggttcgcc  cttacgcaa  ggagattga  aggatttta  999



<210> 9622
<211> 295
<212> PRT
<213> Rattus norvegicus
<308> P24329
<400> 9622

His Gln Val Leu Tyr Arg Ala Leu Val Ser Thr Lys Trp Leu Ala Glu 
  1               5                  10                  15
Ser Ile Arg Ser Gly Lys Val Gly Pro Ser Leu Arg Val Leu Asp Ala 
             20                  25                  30
Ser Trp Tyr Ser Pro Gly Thr Arg Gln Ala Arg Lys Glu Tyr Gln Glu 
         35                  40                  45
Arg His Val Pro Gly Ala Ser Phe Phe Asp Ile Glu Glu Cys Arg Asp 
     50                  55                  60
Thr Thr Ser Pro Tyr Glu Met Met Leu Pro Ser Glu Ala His Phe Gly 
 65                  70                  75                  80
Asp Tyr Val Gly Asn Leu Gly Ile Ser Asn Asp Thr His Val Val Val 
                 85                  90                  95
Tyr Asp Gly Asp Asp Leu Gly Ser Phe Tyr Ala Pro Arg Val Trp Trp 
             100                105                110
Met Phe Arg Val Phe Gly His Arg Thr Val Ser Val Leu Asn Gly Gly 
         115                120                125
Phe Arg Asn Trp Leu Lys Glu Gly His Pro Val Thr Ser Glu Pro Ser 
     130                135                140
Arg Pro Glu Pro Ala Val Phe Lys Ala Thr Leu Asn Arg Ser Leu Leu 
 145                150                155                160
Lys Thr Tyr Glu Gln Val Leu Glu Asn Leu Gln Ser Lys Arg Phe Gln 
                 165                170                175
Leu Val Asp Ser Arg Ala Gln Gly Arg Tyr Leu Gly Thr Gln Pro Glu 
             180                185                190
Pro Asp Ala Val Gly Leu Asp Ser Gly His Ile Arg Gly Ser Val Asn 
         195                200                205
Val Pro Phe Met Asn Phe Leu Thr Glu Asp Gly Phe Glu Lys Ser Pro 
     210                215                220
Glu Glu Leu Arg Ala Ile Phe Gln Asp Lys Lys Val Asp Leu Ser Gln 
 225                230                235                240
Pro Leu Ile Ala Thr Cys Arg Lys Gly Val Thr Ala Cys His Ile Ala 
                 245                250                255
Leu Ala Ala Tyr Leu Cys Gly Lys Pro Asp Val Ala Val Tyr Asp Gly 
             260                265                270
Ser Trp Ser Glu Trp Phe Arg Arg Ala Pro Pro Glu Thr Arg Val Ser 
         275                280                285
Gln Gly Lys Ser Gly Lys Ala 
     290                295



<210> 9623
<211> 999
<212> DNA
<213> Rattus norvegicus
<308> X56228
<400> 9623

catcaggtg  tctaccgag  gctggtctc  accaagtgg  tggcggaat  cattcggtc  60
ggcaaggtg  ggccaagcc  tcgggtgct  gacgcgtca  ggtactcac  agggacccg  120
caggcacgc  aagagtacc  ggagcgaca  gtgcctggc  cgtccttct  tgatataga  180
gagtgccgg  acacgactt  gccttacga  atgatgctg  ccagtgagg  ccactttgg  240
gactacgtg  gcaacctgg  cataagcaa  gacacacac  tcgtggtat  cgatggaga  300
gacctgggc  gcttctatg  acccagagt  tggtggatg  ttcgtgtgt  tggccaccg  360
acagtatca  tgctcaatg  tggcttccg  aactggctg  aggagggcc  cccggtgac  420
tctgaaccc  cgcggccag  gccagccgt  ttcaaagcc  cactgaacc  ctccctgct  480
aagacctat  agcaggtcc  ggagaacct  cagtctaaa  ggttccagc  ggtggattc  540
cgggcccag  gacggtacc  gggcacaca  ccggagccc  atgcagtag  actggactc  600
ggccacatc  gtggctctg  caacgtgcc  ttcatgaac  tcctgacag  agatggctt  660
gagaagagc  cagaggagc  gcgtgccat  ttccaggac  agaaggtgg  cctctccca  720
ccccttatc  ccacatgcc  caaaggggt  actgcttgc  acattgccc  ggctgccta  780
ctttgtggc  agcccgatg  ggctgttta  gatggctcc  ggtcagagt  gtttcgcag  840
gcccccccg  agacccgtg  gtcccaggg  aagagtggg  aggcctgag  gtgtgcagc  900
tcctcttcc  cccaccaga  ccagccagt  cccttcagt  aggcttgta  gacctgctg  960
aggttcgcc  cttacgcaa  ggagattga  aggatttta  999



<210> 9624
<211> 295
<212> PRT
<213> Rattus norvegicus
<308> P24329
<400> 9624

His Gln Val Leu Tyr Arg Ala Leu Val Ser Thr Lys Trp Leu Ala Glu 
  1               5                  10                  15
Ser Ile Arg Ser Gly Lys Val Gly Pro Ser Leu Arg Val Leu Asp Ala 
             20                  25                  30
Ser Trp Tyr Ser Pro Gly Thr Arg Gln Ala Arg Lys Glu Tyr Gln Glu 
         35                  40                  45
Arg His Val Pro Gly Ala Ser Phe Phe Asp Ile Glu Glu Cys Arg Asp 
     50                  55                  60
Thr Thr Ser Pro Tyr Glu Met Met Leu Pro Ser Glu Ala His Phe Gly 
 65                  70                  75                  80
Asp Tyr Val Gly Asn Leu Gly Ile Ser Asn Asp Thr His Val Val Val 
                 85                  90                  95
Tyr Asp Gly Asp Asp Leu Gly Ser Phe Tyr Ala Pro Arg Val Trp Trp 
             100                105                110
Met Phe Arg Val Phe Gly His Arg Thr Val Ser Val Leu Asn Gly Gly 
         115                120                125
Phe Arg Asn Trp Leu Lys Glu Gly His Pro Val Thr Ser Glu Pro Ser 
     130                135                140
Arg Pro Glu Pro Ala Val Phe Lys Ala Thr Leu Asn Arg Ser Leu Leu 
 145                150                155                160
Lys Thr Tyr Glu Gln Val Leu Glu Asn Leu Gln Ser Lys Arg Phe Gln 
                 165                170                175
Leu Val Asp Ser Arg Ala Gln Gly Arg Tyr Leu Gly Thr Gln Pro Glu 
             180                185                190
Pro Asp Ala Val Gly Leu Asp Ser Gly His Ile Arg Gly Ser Val Asn 
         195                200                205
Val Pro Phe Met Asn Phe Leu Thr Glu Asp Gly Phe Glu Lys Ser Pro 
     210                215                220
Glu Glu Leu Arg Ala Ile Phe Gln Asp Lys Lys Val Asp Leu Ser Gln 
 225                230                235                240
Pro Leu Ile Ala Thr Cys Arg Lys Gly Val Thr Ala Cys His Ile Ala 
                 245                250                255
Leu Ala Ala Tyr Leu Cys Gly Lys Pro Asp Val Ala Val Tyr Asp Gly 
             260                265                270
Ser Trp Ser Glu Trp Phe Arg Arg Ala Pro Pro Glu Thr Arg Val Ser 
         275                280                285
Gln Gly Lys Ser Gly Lys Ala 
     290                295



<210> 9625
<211> 342
<212> DNA
<213> Rattus norvegicus
<308> X56306
<400> 9625

caacatgaa  atcctcgtg  cggtggcgg  cttttttct  gtttccact  aactgtttg  60
agaggaaat  ggtgccaac  atgatctaa  ttattggtc  gactggtcc  acagtgacc  120
aatcaagga  gcaatgccg  agccctttg  gcatcttct  cagagaatc  cccgaagac  180
caagcctca  cagttcttt  gattaatgg  caaacggga  gctgggcat  gtcagatct  240
tcacaaaat  gcttatgaa  gaagcgcaa  gcagaacta  gaaagaagg  gtaaataaa  300
cctgtaacg  actatctat  catctccat  tgtgtccgc  ag  342



<210> 9626
<211> 130
<212> PRT
<213> Rattus norvegicus
<308> P06767
<400> 9626

Met Lys Ile Leu Val Ala Val Ala Val Phe Phe Leu Val Ser Thr Gln 
  1               5                  10                  15
Leu Phe Ala Glu Glu Ile Gly Ala Asn Asp Asp Leu Asn Tyr Trp Ser 
             20                  25                  30
Asp Trp Ser Asp Ser Asp Gln Ile Lys Glu Ala Met Pro Glu Pro Phe 
         35                  40                  45
Glu His Leu Leu Gln Arg Ile Ala Arg Arg Pro Lys Pro Gln Gln Phe 
     50                  55                  60
Phe Gly Leu Met Gly Lys Arg Asp Ala Asp Ser Ser Ile Glu Lys Gln 
 65                  70                  75                  80
Val Ala Leu Leu Lys Ala Leu Tyr Gly His Gly Gln Ile Ser His Lys 
                 85                  90                  95
Arg His Lys Thr Asp Ser Phe Val Gly Leu Met Gly Lys Arg Ala Leu 
             100                105                110
Asn Ser Val Ala Tyr Glu Arg Ser Ala Met Gln Asn Tyr Glu Arg Arg 
         115                120                125
Arg Lys 
     130



<210> 9627
<211> 1021
<212> DNA
<213> Homo sapiens
<308> X54469
<400> 9627

gagagtgcg  agcgaccac  tgcgctcgg  ggaaccaga  aaactcagc  ccccgcggg  60
ctgtccgtc  caaaatcca  catgaaaat  ctcgtggcc  tggcagtct  ttttcttgt  120
tccactcag  tgtttgcag  agaaatagg  gccaatgat  atctgaatt  ctggtccga  180
tggtacgac  gcgaccaga  caaggagga  ctgccggag  cctttgagc  tcttctgca  240
agaatcgcc  ggagaccca  gcctcagca  ttctttgga  taatgggca  acgggatgc  300
gattcctca  ttgaaaaac  agtggccct  ttaaaggct  tttatggac  tggccagat  360
tctcacaaa  gacataaaa  agattcctt  gttggacta  tgggcaaaa  agctttaaa  420
tctgtggct  atgaaagga  tgcaatgca  aattatgaa  gaagacgtt  ataaactac  480
taacattat  tattcagct  catttgtgt  aatgggcaa  gacaggtaa  ttaagacat  540
cactatgag  aataattat  tatttaata  caattgttt  gggttgaaa  ttcaaaaag  600
gtttatttt  catattgtg  caatatgta  tgtaaacat  tgttttaat  ccaatatga  660
gactccctt  aaatagaaa  aagtggtta  ttctcaaca  agcacagtg  taaatgaaa  720
tgtaaaacc  gtcaatgat  cagtcccta  agaaaaaaa  tcattgctt  gaagcagtt  780
tgtcagcta  tgcggaaaa  gaaggaaac  cctgacagt  ttgtgcttt  cctatttgt  840
ttcatggtg  aaatgtact  agattttgg  attacactg  atttgtatc  ctgaagcat  900
tttcatgtt  tgtgactat  tagagatgt  tttaaaagt  tcaatgtga  tctaatgtc  960
tcatttcat  gtatgatgt  ttgtgatag  taacatttt  aataaaaga  aaaatatct  1020
g  1021



<210> 9628
<211> 129
<212> PRT
<213> Homo sapiens
<308> P20366
<400> 9628

Met Lys Ile Leu Val Ala Leu Ala Val Phe Phe Leu Val Ser Thr Gln 
  1               5                  10                  15
Leu Phe Ala Glu Glu Ile Gly Ala Asn Asp Asp Leu Asn Tyr Trp Ser 
             20                  25                  30
Asp Trp Tyr Asp Ser Asp Gln Ile Lys Glu Glu Leu Pro Glu Pro Phe 
         35                  40                  45
Glu His Leu Leu Gln Arg Ile Ala Arg Arg Pro Lys Pro Gln Gln Phe 
     50                  55                  60
Phe Gly Leu Met Gly Lys Arg Asp Ala Asp Ser Ser Ile Glu Lys Gln 
 65                  70                  75                  80
Val Ala Leu Leu Lys Ala Leu Tyr Gly His Gly Gln Ile Ser His Lys 
                 85                  90                  95
Arg His Lys Thr Asp Ser Phe Val Gly Leu Met Gly Lys Arg Ala Leu 
             100                105                110
Asn Ser Val Ala Tyr Glu Arg Ser Ala Met Gln Asn Tyr Glu Arg Arg 
         115                120                125
Arg 
     130



<210> 9629
<211> 693
<212> DNA
<213> Rattus norvegicus
<308> X56551
<400> 9629

caatctaca  ttcacagat  ggaggaggc  catgaccta  gagtagcga  caactcaag  60
tccagttct  attatgtta  tcatggaca  ccggggcac  gctctataa  gcgcaaatg  120
atactgaca  ggatcctgc  gactccgct  tacagaccg  gcttccacc  cgtctgtct  180
gtgggcacc  tatctttag  ttgcaatga  atgagtcca  agcagacgg  cacgagcgt  240
aactgttct  gccccgagc  acacacgag  agttatgac  acatggaag  aggggatat  300
agggtgagg  gactgttct  tcgcaccca  tggtacctg  ggattgaca  acgaggcaa  360
gtgaaaggg  cccaggaga  gaggaacag  tacaacatc  tggaaatca  gactgtggc  420
gttggaatt  tggcaatca  aggggtgga  agtgaatac  atcttgcca  gaacaaaca  480
ggggaactc  atgcaaaga  agaatgcaa  gaggattgc  acttcaaag  actgattct  540
gaaaaccat  acaacacct  tgcatcagc  aaatggaca  acagcggag  ggaaatgtt  600
gtggcctta  atcaaaagg  gcttcctgt  aaagggaag  aaacgaaga  agaacaaaa  660
acggcccac  ttcttccta  ggcaataac  taa  693



<210> 9630
<211> 194
<212> PRT
<213> Rattus norvegicus
<308> Q02195
<400> 9630

Met Arg Lys Trp Ile Leu Thr Arg Ile Leu Pro Thr Pro Leu Tyr Arg 
  1               5                  10                  15
Pro Cys Phe His Leu Val Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 
             20                  25                  30
Asn Asp Met Ser Pro Glu Gln Thr Ala Thr Ser Val Asn Cys Ser Ser 
         35                  40                  45
Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 
     50                  55                  60
Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 
 65                  70                  75                  80
Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Arg Asn Ser Tyr Asn 
                 85                  90                  95
Ile Met Glu Ile Met Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly 
             100                105                110
Val Glu Ser Glu Tyr Tyr Leu Ala Met Asn Lys Gln Gly Glu Leu Tyr 
         115                120                125
Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu 
     130                135                140
Glu Asn His Tyr Asn Thr Ser Ala Ser Ala Lys Trp Thr His Ser Gly 
 145                150                155                160
Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Leu Pro Val Lys Gly 
                 165                170                175
Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala 
             180                185                190
Ile Thr 
         195



<210> 9631
<211> 194
<212> PRT
<213> Homo sapiens
<308> P21781
<400> 9631

Met His Lys Trp Ile Leu Thr Trp Ile Leu Pro Thr Leu Leu Tyr Arg 
  1               5                  10                  15
Ser Cys Phe His Ile Ile Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 
             20                  25                  30
Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser Ser 
         35                  40                  45
Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 
     50                  55                  60
Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 
 65                  70                  75                  80
Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr Asn 
                 85                  90                  95
Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly 
             100                105                110
Val Glu Ser Glu Phe Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu Tyr 
         115                120                125
Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu 
     130                135                140
Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Asn Gly 
 145                150                155                160
Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Ile Pro Val Arg Gly 
                 165                170                175
Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala 
             180                185                190
Ile Thr 
         195



<210> 9632
<211> 1374
<212> DNA
<213> Rattus norvegicus
<308> X56596
<400> 9632

cttagagat  gctctgcag  cccccagct  cctcctccc  gcagctgtg  ttgtgctga  60
ggtgctgag  agcccaggg  ctgagggca  agactcccc  agggatttc  tgtaccagt  120
caagggcct  tgctactac  ccaacggga  gcagcgcat  cgggatgtg  tcagataca  180
ctacaacca  gaggagtac  tgcgctacg  cagcgacgt  ggcgagtac  gcgcgctga  240
cgagctggg  cggccctca  ccgagtact  taacaagca  tacctggag  agacgcggg  300
cgagctgga  acggtctgc  gacacaact  cgaggggtc  gaggtccgc  cctccctgc  360
gcggcttga  cagcccaat  tggccatct  cctgtccag  acagaggcc  tcaaccacc  420
caacttgct  gtctgctca  tgacagatt  ctacccagc  cagatcaaa  tgcgctggt  480
ccggaatgg  caggaggag  cggcggggg  cgtgtccac  cagcttatt  ggaacgggg  540
ctggacctt  cagatcctg  tcatgctgg  gatgacgcc  cagcgggga  aggtgtaca  600
ctgccatgt  gaccacccc  gccttgaga  ccccgtcac  gtggagtgg  gggcacagt  660
cgagtctgc  cagagcaag  tgctgagcg  catcggggg  tttgtgctg  gggtgatct  720
cctcgggct  ggccttttc  tccgtcaca  gcgtcagaa  ggacctcgg  ggcctcctc  780
agcagggct  ctacagtga  acaggagag  gttttggtt  tgtttgaag  gacatggga  840
acctgcccc  atctctccg  atcaaatcc  gcaattctt  tgtccctac  gagccagag  900
agttagcac  ccccccccc  cgggccgac  ctggccttg  gaacagaca  aaggcagcc  960
tctccaacc  cagcatcac  tcagaactc  tactccctc  cctggttag  aaccagcat  1020
tctctggtg  agatggctc  tgcccttga  ggaggcggg  gccaatatc  ttgaagtga  1080
gaaagccca  tctcggact  tgagaaaga  gcaattaag  gtcaagtgt  cccagacag  1140
tgcgaccag  tgtgaaata  cctagcttc  gataacgga  tgagttact  cttcccagt  1200
aggaaggta  gccctttcc  gcactcccc  ccccatctg  acaggtttg  ctcagggtt  1260
gaaggatgg  actccttta  cccctcccc  atcacatac  gccaaagct  gagaagccc  1320
cgttacgca  attcctata  atgtcacaa  ccccttgat  tgagcattg  attc  1374



<210> 9633
<211> 263
<212> PRT
<213> Rattus norvegicus
<308> P29826
<400> 9633

Met Ala Leu Gln Thr Pro Ser Phe Leu Leu Pro Ala Ala Val Val Val 
  1               5                  10                  15
Leu Met Val Leu Ser Ser Pro Gly Thr Glu Gly Arg Asp Ser Pro Arg 
             20                  25                  30
Asp Phe Val Tyr Gln Phe Lys Gly Leu Cys Tyr Tyr Thr Asn Gly Thr 
         35                  40                  45
Gln Arg Ile Arg Asp Val Ile Arg Tyr Ile Tyr Asn Gln Glu Glu Tyr 
     50                  55                  60
Leu Arg Tyr Asp Ser Asp Val Gly Glu Tyr Arg Ala Leu Thr Glu Leu 
 65                  70                  75                  80
Gly Arg Pro Ser Ala Glu Tyr Phe Asn Lys Gln Tyr Leu Glu Gln Thr 
                 85                  90                  95
Arg Ala Glu Leu Asp Thr Val Cys Arg His Asn Tyr Glu Gly Ser Glu 
             100                105                110
Val Arg Thr Ser Leu Arg Arg Leu Glu Gln Pro Asn Val Ala Ile Ser 
         115                120                125
Leu Ser Arg Thr Glu Ala Leu Asn His His Asn Leu Leu Val Cys Ser 
     130                135                140
Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val Arg Trp Phe Arg Asn 
 145                150                155                160
Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Gln Leu Ile Arg Asn 
                 165                170                175
Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro Gln 
             180                185                190
Arg Gly Glu Val Tyr Ile Cys His Val Asp His Pro Ser Leu Glu Ser 
         195                200                205
Pro Val Thr Val Glu Trp Arg Ala Gln Ser Glu Ser Ala Gln Ser Lys 
     210                215                220
Met Leu Ser Gly Ile Gly Gly Phe Val Leu Gly Val Ile Phe Leu Gly 
 225                230                235                240
Leu Gly Leu Phe Ile Arg His Lys Arg Gln Lys Gly Pro Arg Gly Pro 
                 245                250                255
Pro Pro Ala Gly Leu Leu Gln 
             260



<210> 9634
<211> 428
<212> DNA
<213> Homo sapiens
<308> BM727355
<400> 9634

ttgaaggag  cgggagcca  tatccttga  gtgatgaaa  cccactctc  actatgaga  60
aaaggcaat  aagtgtcaa  tgtgcccac  cagctgaga  cagttgtga  ataccctag  120
ttctgataa  ggaatgagt  acttcttcc  aggtcagga  ggtaggtcc  tttccaaca  180
tccccaccc  atctgaaca  gtttgtctc  gggttggaa  gatggcact  ctttacccc  240
tccccaatc  catactgcc  aagctcgag  agcccagct  acgcatatt  ctatatatg  300
cacaagccc  ttgatgtga  cattgaatt  ctaacctgt  gaacaggga  ggcttgtga  360
ctgatttgg  tcagacccg  ataataaag  ttctctttg  tcttgcaaa  aaaaaaaaa  420
aaaaagac  428



<210> 9635
<211> 268
<212> PRT
<213> Homo sapiens
<308> P05538
<400> 9635

Met Ser Trp Lys Met Ala Leu Gln Ile Pro Gly Gly Phe Trp Ala Ala 
  1               5                  10                  15
Ala Val Thr Val Met Leu Val Met Leu Ser Thr Pro Val Ala Glu Ala 
             20                  25                  30
Arg Asp Phe Pro Lys Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr 
         35                  40                  45
Phe Thr Asn Gly Thr Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr 
     50                  55                  60
Asn Arg Glu Glu Tyr Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln 
 65                  70                  75                  80
Ala Val Thr Glu Leu Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys 
                 85                  90                  95
Asp Phe Leu Glu Gln Glu Arg Ala Ala Val Asp Lys Val Cys Arg His 
             100                105                110
Asn Tyr Glu Ala Glu Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro 
         115                120                125
Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His Asn 
     130                135                140
Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val 
 145                150                155                160
Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr 
                 165                170                175
Ser Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu 
             180                185                190
Glu Ile Thr Pro Gln Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His 
         195                200                205
Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser Glu 
     210                215                220
Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu Gly 
 225                230                235                240
Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg His Arg Gly Gln Lys 
                 245                250                255
Gly Pro Arg Gly Pro Pro Pro Ala Gly Leu Leu His 
             260                265



<210> 9636
<211> 1931
<212> DNA
<213> Rattus norvegicus
<308> X56729
<400> 9636

ctggcacat  tcccagaat  agtaccaca  gagctaagc  acctgtgat  catgagaaa  60
agccaaaag  aaagccaaa  gaagggtca  agacaaaat  tcaagatgc  ccttctgct  120
atggagaga  tgtggctgg  gatgtgact  tggccactg  ctcagacga  gtggttgtt  180
agaaaaaag  gaagaaatc  ttaacacct  ctttaccta  ggagtccac  ctaaacaag  240
tatctgaca  gtcaggcgt  aatgctgct  tggatgacc  gatagacac  ttaggtgaa  300
gtgaagata  taacaaaga  gatccacca  atactggac  agtagttct  gacccaatg  360
attctacct  ccttgaggc  ctgggtata  aagaaggga  tattcctcc  gagtatagg  420
aacttctgg  gaaaaatga  gctatcaca  gacctcttc  agattctcc  aaacctatg  480
gaatcgacc  tgctataga  gccttgtca  ctgatttca  ctgtagctc  ccaactgga  540
agcaaactg  gaaagagaa  tctactggg  aaagttcga  agctcagtc  gcaggagtg  600
ccagaagtg  tgttcctcc  caggagaag  aaaggaaag  agaagagga  gtcatgaat  660
atcaagccc  gcaggctct  tcagattca  tgggcaccc  gcagccaga  cctcagagc  720
atcttaggc  agccaaaca  gtcaaagag  caaaagcaa  agaagaaag  caggagaaa  780
gtggtgaag  tgaggacac  gtacctgct  agtacaggt  aaaaccagc  aaggataaa  840
atggaaaac  actattgcc  gaacctgaa  aaacatcta  gtgcctgag  gagtcagag  900
tgattgggg  gctttcagc  gattttgtc  aacctacat  tcaagaaaa  ccatctatg  960
cagctgcaa  aataaagaa  ggcgtagtg  cagatgatg  tgtagaaac  ttggctaga  1020
gcctgggga  aaggaaaga  gatccagaa  atgaaaaat  tctggtgga  aaagtcaag  1080
agaaagcta  agaagaaga  catgaaaaa  ttggtgaaa  agaagaaac  attcctcct  1140
attatcgac  agaaatagt  aaggataag  atggaaaac  gctcctgcc  aaagaagcc  1200
aggaacaac  tccaccctt  agcgatgac  tccttcttg  tgcattgtc  caggacttc  1260
ccagtcctg  aaacatatt  tctcttggt  ttgaagatg  caaactttc  gctgctgtt  1320
ctgaaacag  ttcccaggt  cctgctcca  gcaaccaca  agcagcccc  ccgcctggc  1380
ctgagagga  agacaaaga  ctcgatgat  ccttggatg  actttctga  agtcttgga  1440
aaagacagc  tgatccaga  gagaacaaa  cactagatg  taaagtaaa  gaaaaaatc  1500
aagcagagc  tagcgagaa  ctgggagaa  gagacgaca  catcccccc  gaatatagg  1560
atctcctgg  taatgatgg  aaggacaaa  cagagaagc  acttgacaa  gaacacaga  1620
aagctggtc  ggaccagga  cccattgat  ccctctcag  agacttgga  agctgcccc  1680
caactacag  gacttcaca  aatacaaca  aggagaagg  taagaagac  tcaagttcc  1740
aagcatcca  gaatgaaga  aaaacaaag  attcctcca  gaagacaga  gaagtgccc  1800
agccaaagg  ggatgaaga  gcaacataa  gtttatgca  tttggtatc  gaataaaaa  1860
tcttcagct  gtggatggt  acttttgaa  atcaaaggc  ttgatgaca  tttttctgg  1920
tggcttcta  a  1931



<210> 9637
<211> 654
<212> PRT
<213> Rattus norvegicus
<308> CAA40053
<400> 9637

Met Ser Thr Thr Gly Ala Lys Ala Val Lys Ile Glu Ser Glu Lys Ser 
  1               5                  10                  15
Gln Ser Ser Glu Pro Pro Val Ile His Glu Lys Lys Pro Lys Gly Lys 
             20                  25                  30
Pro Lys Glu Gly Ser Glu Pro Gln Thr Leu Pro Lys His Ala Ser Asp 
         35                  40                  45
Thr Gly Ser Lys His Ala His Lys Glu Lys Ala Leu Ser Arg Ser Asn 
     50                  55                  60
Glu Gln Ile Val Ser Glu Lys Ser Ser Glu Ser Lys Thr Lys Phe Gln 
 65                  70                  75                  80
Asp Ala Pro Ser Ala Asp Gly Glu Ser Val Ala Gly Gly Val Thr Val 
                 85                  90                  95
Ala Thr Ala Ser Asp Lys Val Val Val Lys Lys Lys Glu Lys Lys Ser 
             100                105                110
Leu Thr Pro Thr Leu Pro Met Glu Ser Thr Leu Asn Lys Leu Ser Asp 
         115                120                125
Lys Ser Gly Val Asn Ala Ala Leu Asp Asp Leu Ile Asp Thr Leu Gly 
     130                135                140
Glu Cys Glu Asp Thr Asn Lys Asp Asp Pro Pro Tyr Thr Gly Pro Val 
 145                150                155                160
Val Leu Asp Pro Met Asp Ser Thr Tyr Leu Glu Ala Leu Gly Ile Lys 
                 165                170                175
Glu Gly Thr Ile Pro Pro Glu Tyr Arg Lys Leu Leu Glu Lys Asn Glu 
             180                185                190
Ala Ile Thr Gly Pro Leu Pro Asp Ser Pro Lys Pro Met Gly Ile Asp 
         195                200                205
His Ala Ile Asp Ala Leu Ser Ser Asp Phe Thr Cys Ser Ser Pro Thr 
     210                215                220
Gly Lys Gln Thr Glu Lys Glu Lys Ser Thr Gly Glu Ser Ser Lys Ala 
 225                230                235                240
Gln Ser Ala Gly Val Thr Arg Ser Ala Val Pro Pro Gln Glu Lys Lys 
                 245                250                255
Arg Lys Val Glu Glu Glu Val Met Asn Asp Gln Ala Leu Gln Ala Leu 
             260                265                270
Ser Asp Ser Leu Gly Thr Arg Gln Pro Asp Pro Gln Ser His Leu Arg 
         275                280                285
Gln Ala Lys Gln Val Lys Glu Ala Lys Ala Lys Glu Glu Arg Gln Glu 
     290                295                300
Lys Cys Gly Glu Asp Glu Asp Thr Val Pro Ala Glu Tyr Arg Leu Lys 
 305                310                315                320
Pro Ala Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro Glu Pro Glu Glu 
                 325                330                335
Thr Ser Lys Cys Leu Ser Glu Ser Glu Leu Ile Gly Glu Leu Ser Ala 
             340                345                350
Asp Phe Val Gln Pro Thr Tyr Gln Glu Lys Pro Ser Met Pro Ala Ala 
         355                360                365
Lys Ile Lys Lys Gly Val Val Pro Asp Asp Ala Val Glu Thr Leu Ala 
     370                375                380
Arg Ser Leu Gly Thr Arg Lys Glu Asp Pro Glu Asp Glu Lys Ser Leu 
 385                390                395                400
Val Asp Lys Val Lys Glu Lys Ala Lys Glu Glu Asp His Glu Lys Leu 
                 405                410                415
Gly Glu Lys Glu Glu Thr Ile Pro Pro Asp Tyr Arg Leu Glu Ile Val 
             420                425                430
Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro Lys Glu Ala Glu Glu Gln 
         435                440                445
Leu Pro Pro Leu Ser Asp Asp Phe Leu Leu Asp Ala Leu Ser Gln Asp 
     450                455                460
Phe Ser Ser Pro Ala Asn Ile Leu Ser Leu Gly Phe Glu Asp Ala Lys 
 465                470                475                480
Leu Ser Ala Ala Val Ser Glu Thr Val Ser Gln Val Pro Ala Pro Ser 
                 485                490                495
Asn His Thr Ala Ala Pro Pro Pro Gly Thr Glu Arg Arg Asp Lys Glu 
             500                505                510
Leu Asp Asp Ala Leu Asp Glu Leu Ser Asp Ser Leu Gly Gln Arg Gln 
         515                520                525
Pro Asp Pro Asp Glu Asn Lys Pro Leu Asp Asp Lys Val Lys Glu Lys 
     530                535                540
Ile Lys Ala Glu His Ser Glu Lys Leu Gly Glu Arg Asp Asp Thr Ile 
 545                550                555                560
Pro Pro Glu Tyr Arg His Leu Leu Asp Asn Asp Gly Lys Asp Lys Pro 
                 565                570                575
Glu Lys Pro Leu Asp Lys Glu His Arg Glu Ala Gly Gln Asp Gln Asp 
             580                585                590
Pro Ile Asp Ala Leu Ser Glu Asp Leu Asp Ser Cys Pro Pro Thr Thr 
         595                600                605
Glu Thr Ser Gln Asn Thr Thr Lys Glu Lys Gly Lys Lys Thr Ser Ser 
     610                615                620
Ser Lys Ala Ser Lys Asn Glu Glu Lys Thr Lys Asp Ser Ser Lys Lys 
 625                630                635                640
Thr Glu Glu Val Pro Lys Pro Lys Val Asp Glu Asp Ala Thr 
                 645                650



<210> 9638
<211> 2493
<212> DNA
<213> Homo sapiens
<308> D16217
<400> 9638

acattggta  ggtgttttc  cccattgaa  ctaatattt  ctattttca  gaaaaaagc  60
gcaagcctc  gcagcagtc  atcctccag  acctatgct  gtggaacag  ctcggccac  120
aaggtgtca  cttcctctg  tgcaaccag  aagtcttcc  gtatgaatc  cacagaaac  180
aaggccatt  cagtcagcc  acagatgga  ggaccacat  ttcctaaca  gaaaaaaca  240
aaaaaacag  ctgtaaaaa  agaacctga  aagaagtca  agtcaacca  gctgtctgt  300
gttcatgag  aaaaatccc  agaaggaaa  ccaaaagaa  acacagagc  aaaaagcct  360
cccaagcag  catcagata  aggaagtaa  gatgctcac  ataaaaaag  agtttccag  420
tcagctgaa  agcagccat  agagaaatc  acagaacca  agactaaac  acaagacat  480
atttctgct  gtggagaga  tgttgctgg  atcactgca  tatctggca  gccgggtga  540
aagaaaaaa  aaaagaaat  attaacccc  gctgtgcca  ttgaatcta  accggataa  600
ccatcggga  agtcaggca  ggatgctgc  ttggatgac  taatagata  tttaggagg  660
cctgaagaa  ctgaagaag  aaatacaac  tatactgga  cagaagttt  agatccaat  720
agttccacc  acatagagg  attgggtaa  agagaagtc  caattcctc  aaaatatag  780
gaactattg  ctaaaaagg  agggatcac  gggcctcct  cagactctt  aaaacccat  840
gggccagat  atgctatag  cgccttgtc  tctgacttc  cctgtgggt  gcctacagc  900
gctggaaag  aaactgaaa  agaggaatc  acagaagtt  taaaagctc  gtcagcagg  960
acagtcaga  gtgctgctc  accccaaga  aagaaaaga  aggtggaga  ggatacaat  1020
agtgatcaa  cactcgagg  tctgtcggc  tcactgggc  cccggcaag  agaacctga  1080
ctcgacctc  gctcaatta  ggaagtcga  gaggcaaaa  ctaaagaag  aaaactaga  1140
aagtgtggt  aggatgatg  aacaatccc  tctgagtac  gattaaaac  agccacgga  1200
aaagatgga  aaccactat  gccagagcc  gaagaaaaa  ccaagcctc  gagtgaatc  1260
gaactcatt  atgaacttt  agaagattt  gaccggtct  aatgtaaag  gaaaccatc  1320
aagccaact  aaaagacag  agaatctaa  gccgctgct  cagctcctg  gtcggaggc  1380
gtgtctcgg  cctccatgt  tagtataca  tcagcaccc  ctgagccgg  taccttgaa  1440
ggcacagtg  cagatgatg  tgtagaagc  ttggctgat  gcctgggga  aaaggaagc  1500
gatccagaa  atggaaaac  tgtgatgga  aaagtcaag  agaaggcca  agaagaaga  1560
cgtgaaaag  ttggtgaaa  agaagaaac  attcctcct  attatagat  agaagaggt  1620
aaggataaa  atggaaagc  actcctgcc  aaagagtct  aggaacagc  tccacccat  1680
agtgaagac  tccttctgg  tgctttgtc  gaggacttc  ctggtccac  aaatgcttc  1740
tctcttaaa  ttgaagatg  taaacttgc  gctgccatc  ctgaagtgg  ttcccaaac  1800
ccagcttca  cgacccaag  tggagcccc  ccccgtgat  cctcgcaga  tgacaaaga  1860
ctcgatgat  ccttggata  actctctga  agtctagga  aaaggcagc  tgacccaga  1920
gagaacaaa  caatgggag  taaagtaaa  gaaaaagct  aagctgaac  tagagacaa  1980
cttggagaa  gagatgaca  tatcccacc  gaatacaga  atctcctgg  tgataatgg  2040
caggacaaa  cagtgaagc  acctacaaa  aaatcagag  attcaaaga  acctgcaga  2100
gaccaagac  ccattgatg  tctctcagg  gatctggac  gctgtccct  cactacaga  2160
acctcacag  acacagcaa  ggataagtg  aagaaggct  cttccagct  caaagcacc  2220
aagaatgga  gtaaagcga  ggattcagc  aagacaaca  aggaaactt  caagccaaa  2280
gatgactaa  gaaatacaa  ttaaggtat  tggtatctg  atgtaaaat  ttcagctgg  2340
ggatggtga  ttttgaaga  caaaaggct  tggcaacag  aaacaattg  tctgggtga  2400
ttctagaat  gtttttgtt  agtctctga  catcctaaa  attggtttg  tattctttc  2460
agaaagaaa  tgaatttga  tggttcgga  ttc  2493



<210> 9639
<211> 708
<212> PRT
<213> Homo sapiens
<308> P20810
<400> 9639

Met Asn Pro Thr Glu Thr Lys Ala Ile Pro Val Ser Gln Gln Met Glu 
  1               5                  10                  15
Gly Pro His Leu Pro Asn Lys Lys Lys His Lys Lys Gln Ala Val Lys 
             20                  25                  30
Thr Glu Pro Glu Lys Lys Ser Gln Ser Thr Lys Leu Ser Val Val His 
         35                  40                  45
Glu Lys Lys Ser Gln Glu Gly Lys Pro Lys Glu His Thr Glu Pro Lys 
     50                  55                  60
Ser Leu Pro Lys Gln Ala Ser Asp Thr Gly Ser Asn Asp Ala His Asn 
 65                  70                  75                  80
Lys Lys Ala Val Ser Arg Ser Ala Glu Gln Gln Pro Ser Glu Lys Ser 
                 85                  90                  95
Thr Glu Pro Lys Thr Lys Pro Gln Asp Met Ile Ser Ala Gly Gly Glu 
             100                105                110
Ser Val Ala Gly Ile Thr Ala Ile Ser Gly Lys Pro Gly Asp Lys Lys 
         115                120                125
Lys Glu Lys Lys Ser Leu Thr Pro Ala Val Pro Val Glu Ser Lys Pro 
     130                135                140
Asp Lys Pro Ser Gly Lys Ser Gly Met Asp Ala Ala Leu Asp Asp Leu 
 145                150                155                160
Ile Asp Thr Leu Gly Gly Pro Glu Glu Thr Glu Glu Glu Asn Thr Thr 
                 165                170                175
Tyr Thr Gly Pro Glu Val Ser Asp Pro Met Ser Ser Thr Tyr Ile Glu 
             180                185                190
Glu Leu Gly Lys Arg Glu Val Thr Ile Pro Pro Lys Tyr Arg Glu Leu 
         195                200                205
Leu Ala Lys Lys Glu Gly Ile Thr Gly Pro Pro Ala Asp Ser Ser Lys 
     210                215                220
Pro Ile Gly Pro Asp Asp Ala Ile Asp Ala Leu Ser Ser Asp Phe Thr 
 225                230                235                240
Cys Gly Ser Pro Thr Ala Ala Gly Lys Lys Thr Glu Lys Glu Glu Ser 
                 245                250                255
Thr Glu Val Leu Lys Ala Gln Ser Ala Gly Thr Val Arg Ser Ala Ala 
             260                265                270
Pro Pro Gln Glu Lys Lys Arg Lys Val Glu Lys Asp Thr Met Ser Asp 
         275                280                285
Gln Ala Leu Glu Ala Leu Ser Ala Ser Leu Gly Thr Arg Gln Ala Glu 
     290                295                300
Pro Glu Leu Asp Leu Arg Ser Ile Lys Glu Val Asp Glu Ala Lys Ala 
 305                310                315                320
Lys Glu Glu Lys Leu Glu Lys Cys Gly Glu Asp Asp Glu Thr Ile Pro 
                 325                330                335
Ser Glu Tyr Arg Leu Lys Pro Ala Thr Asp Lys Asp Gly Lys Pro Leu 
             340                345                350
Leu Pro Glu Pro Glu Glu Lys Pro Lys Pro Arg Ser Glu Ser Glu Leu 
         355                360                365
Ile Asp Glu Leu Ser Glu Asp Phe Asp Arg Ser Glu Cys Lys Glu Lys 
     370                375                380
Pro Ser Lys Pro Thr Glu Lys Thr Glu Glu Ser Lys Ala Ala Ala Pro 
 385                390                395                400
Ala Pro Val Ser Glu Ala Val Ser Arg Thr Ser Met Cys Ser Ile Gln 
                 405                410                415
Ser Ala Pro Pro Glu Pro Ala Thr Leu Lys Gly Thr Val Pro Asp Asp 
             420                425                430
Ala Val Glu Ala Leu Ala Asp Ser Leu Gly Lys Lys Glu Ala Asp Pro 
         435                440                445
Glu Asp Gly Lys Pro Val Met Asp Lys Val Lys Glu Lys Ala Lys Glu 
     450                455                460
Glu Asp Arg Glu Lys Leu Gly Glu Lys Glu Glu Thr Ile Pro Pro Asp 
 465                470                475                480
Tyr Arg Leu Glu Glu Val Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro 
                 485                490                495
Lys Glu Ser Lys Glu Gln Leu Pro Pro Met Ser Glu Asp Phe Leu Leu 
             500                505                510
Asp Ala Leu Ser Glu Asp Phe Ser Gly Pro Gln Asn Ala Ser Ser Leu 
         515                520                525
Lys Phe Glu Asp Ala Lys Leu Ala Ala Ala Ile Ser Glu Val Val Ser 
     530                535                540
Gln Thr Pro Ala Ser Thr Thr Gln Ala Gly Ala Pro Pro Arg Asp Thr 
 545                550                555                560
Ser Gln Ser Asp Lys Asp Leu Asp Asp Ala Leu Asp Lys Leu Ser Asp 
                 565                570                575
Ser Leu Gly Gln Arg Gln Pro Asp Pro Asp Glu Asn Lys Pro Met Gly 
             580                585                590
Asp Lys Val Lys Glu Lys Ala Lys Ala Glu His Arg Asp Lys Leu Gly 
         595                600                605
Glu Arg Asp Asp Thr Ile Pro Pro Glu Tyr Arg His Leu Leu Asp Asp 
     610                615                620
Asn Gly Gln Asp Lys Pro Val Lys Pro Pro Thr Lys Lys Ser Glu Asp 
 625                630                635                640
Ser Lys Lys Pro Ala Asp Asp Gln Asp Pro Ile Asp Ala Leu Ser Gly 
                 645                650                655
Asp Leu Asp Ser Cys Pro Ser Thr Thr Glu Thr Ser Gln Asn Thr Ala 
             660                665                670
Lys Asp Lys Cys Lys Lys Ala Ala Ser Ser Ser Lys Ala Pro Lys Asn 
         675                680                685
Gly Gly Lys Ala Lys Asp Ser Ala Lys Thr Thr Glu Glu Thr Ser Lys 
     690                695                700
Pro Lys Asp Asp 
 705



<210> 9640
<211> 1931
<212> DNA
<213> Rattus norvegicus
<308> X56729
<400> 9640

ctggcacat  tcccagaat  agtaccaca  gagctaagc  acctgtgat  catgagaaa  60
agccaaaag  aaagccaaa  gaagggtca  agacaaaat  tcaagatgc  ccttctgct  120
atggagaga  tgtggctgg  gatgtgact  tggccactg  ctcagacga  gtggttgtt  180
agaaaaaag  gaagaaatc  ttaacacct  ctttaccta  ggagtccac  ctaaacaag  240
tatctgaca  gtcaggcgt  aatgctgct  tggatgacc  gatagacac  ttaggtgaa  300
gtgaagata  taacaaaga  gatccacca  atactggac  agtagttct  gacccaatg  360
attctacct  ccttgaggc  ctgggtata  aagaaggga  tattcctcc  gagtatagg  420
aacttctgg  gaaaaatga  gctatcaca  gacctcttc  agattctcc  aaacctatg  480
gaatcgacc  tgctataga  gccttgtca  ctgatttca  ctgtagctc  ccaactgga  540
agcaaactg  gaaagagaa  tctactggg  aaagttcga  agctcagtc  gcaggagtg  600
ccagaagtg  tgttcctcc  caggagaag  aaaggaaag  agaagagga  gtcatgaat  660
atcaagccc  gcaggctct  tcagattca  tgggcaccc  gcagccaga  cctcagagc  720
atcttaggc  agccaaaca  gtcaaagag  caaaagcaa  agaagaaag  caggagaaa  780
gtggtgaag  tgaggacac  gtacctgct  agtacaggt  aaaaccagc  aaggataaa  840
atggaaaac  actattgcc  gaacctgaa  aaacatcta  gtgcctgag  gagtcagag  900
tgattgggg  gctttcagc  gattttgtc  aacctacat  tcaagaaaa  ccatctatg  960
cagctgcaa  aataaagaa  ggcgtagtg  cagatgatg  tgtagaaac  ttggctaga  1020
gcctgggga  aaggaaaga  gatccagaa  atgaaaaat  tctggtgga  aaagtcaag  1080
agaaagcta  agaagaaga  catgaaaaa  ttggtgaaa  agaagaaac  attcctcct  1140
attatcgac  agaaatagt  aaggataag  atggaaaac  gctcctgcc  aaagaagcc  1200
aggaacaac  tccaccctt  agcgatgac  tccttcttg  tgcattgtc  caggacttc  1260
ccagtcctg  aaacatatt  tctcttggt  ttgaagatg  caaactttc  gctgctgtt  1320
ctgaaacag  ttcccaggt  cctgctcca  gcaaccaca  agcagcccc  ccgcctggc  1380
ctgagagga  agacaaaga  ctcgatgat  ccttggatg  actttctga  agtcttgga  1440
aaagacagc  tgatccaga  gagaacaaa  cactagatg  taaagtaaa  gaaaaaatc  1500
aagcagagc  tagcgagaa  ctgggagaa  gagacgaca  catcccccc  gaatatagg  1560
atctcctgg  taatgatgg  aaggacaaa  cagagaagc  acttgacaa  gaacacaga  1620
aagctggtc  ggaccagga  cccattgat  ccctctcag  agacttgga  agctgcccc  1680
caactacag  gacttcaca  aatacaaca  aggagaagg  taagaagac  tcaagttcc  1740
aagcatcca  gaatgaaga  aaaacaaag  attcctcca  gaagacaga  gaagtgccc  1800
agccaaagg  ggatgaaga  gcaacataa  gtttatgca  tttggtatc  gaataaaaa  1860
tcttcagct  gtggatggt  acttttgaa  atcaaaggc  ttgatgaca  tttttctgg  1920
tggcttcta  a  1931



<210> 9641
<211> 654
<212> PRT
<213> Rattus norvegicus
<308> CAA40053
<400> 9641

Met Ser Thr Thr Gly Ala Lys Ala Val Lys Ile Glu Ser Glu Lys Ser 
  1               5                  10                  15
Gln Ser Ser Glu Pro Pro Val Ile His Glu Lys Lys Pro Lys Gly Lys 
             20                  25                  30
Pro Lys Glu Gly Ser Glu Pro Gln Thr Leu Pro Lys His Ala Ser Asp 
         35                  40                  45
Thr Gly Ser Lys His Ala His Lys Glu Lys Ala Leu Ser Arg Ser Asn 
     50                  55                  60
Glu Gln Ile Val Ser Glu Lys Ser Ser Glu Ser Lys Thr Lys Phe Gln 
 65                  70                  75                  80
Asp Ala Pro Ser Ala Asp Gly Glu Ser Val Ala Gly Gly Val Thr Val 
                 85                  90                  95
Ala Thr Ala Ser Asp Lys Val Val Val Lys Lys Lys Glu Lys Lys Ser 
             100                105                110
Leu Thr Pro Thr Leu Pro Met Glu Ser Thr Leu Asn Lys Leu Ser Asp 
         115                120                125
Lys Ser Gly Val Asn Ala Ala Leu Asp Asp Leu Ile Asp Thr Leu Gly 
     130                135                140
Glu Cys Glu Asp Thr Asn Lys Asp Asp Pro Pro Tyr Thr Gly Pro Val 
 145                150                155                160
Val Leu Asp Pro Met Asp Ser Thr Tyr Leu Glu Ala Leu Gly Ile Lys 
                 165                170                175
Glu Gly Thr Ile Pro Pro Glu Tyr Arg Lys Leu Leu Glu Lys Asn Glu 
             180                185                190
Ala Ile Thr Gly Pro Leu Pro Asp Ser Pro Lys Pro Met Gly Ile Asp 
         195                200                205
His Ala Ile Asp Ala Leu Ser Ser Asp Phe Thr Cys Ser Ser Pro Thr 
     210                215                220
Gly Lys Gln Thr Glu Lys Glu Lys Ser Thr Gly Glu Ser Ser Lys Ala 
 225                230                235                240
Gln Ser Ala Gly Val Thr Arg Ser Ala Val Pro Pro Gln Glu Lys Lys 
                 245                250                255
Arg Lys Val Glu Glu Glu Val Met Asn Asp Gln Ala Leu Gln Ala Leu 
             260                265                270
Ser Asp Ser Leu Gly Thr Arg Gln Pro Asp Pro Gln Ser His Leu Arg 
         275                280                285
Gln Ala Lys Gln Val Lys Glu Ala Lys Ala Lys Glu Glu Arg Gln Glu 
     290                295                300
Lys Cys Gly Glu Asp Glu Asp Thr Val Pro Ala Glu Tyr Arg Leu Lys 
 305                310                315                320
Pro Ala Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro Glu Pro Glu Glu 
                 325                330                335
Thr Ser Lys Cys Leu Ser Glu Ser Glu Leu Ile Gly Glu Leu Ser Ala 
             340                345                350
Asp Phe Val Gln Pro Thr Tyr Gln Glu Lys Pro Ser Met Pro Ala Ala 
         355                360                365
Lys Ile Lys Lys Gly Val Val Pro Asp Asp Ala Val Glu Thr Leu Ala 
     370                375                380
Arg Ser Leu Gly Thr Arg Lys Glu Asp Pro Glu Asp Glu Lys Ser Leu 
 385                390                395                400
Val Asp Lys Val Lys Glu Lys Ala Lys Glu Glu Asp His Glu Lys Leu 
                 405                410                415
Gly Glu Lys Glu Glu Thr Ile Pro Pro Asp Tyr Arg Leu Glu Ile Val 
             420                425                430
Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro Lys Glu Ala Glu Glu Gln 
         435                440                445
Leu Pro Pro Leu Ser Asp Asp Phe Leu Leu Asp Ala Leu Ser Gln Asp 
     450                455                460
Phe Ser Ser Pro Ala Asn Ile Leu Ser Leu Gly Phe Glu Asp Ala Lys 
 465                470                475                480
Leu Ser Ala Ala Val Ser Glu Thr Val Ser Gln Val Pro Ala Pro Ser 
                 485                490                495
Asn His Thr Ala Ala Pro Pro Pro Gly Thr Glu Arg Arg Asp Lys Glu 
             500                505                510
Leu Asp Asp Ala Leu Asp Glu Leu Ser Asp Ser Leu Gly Gln Arg Gln 
         515                520                525
Pro Asp Pro Asp Glu Asn Lys Pro Leu Asp Asp Lys Val Lys Glu Lys 
     530                535                540
Ile Lys Ala Glu His Ser Glu Lys Leu Gly Glu Arg Asp Asp Thr Ile 
 545                550                555                560
Pro Pro Glu Tyr Arg His Leu Leu Asp Asn Asp Gly Lys Asp Lys Pro 
                 565                570                575
Glu Lys Pro Leu Asp Lys Glu His Arg Glu Ala Gly Gln Asp Gln Asp 
             580                585                590
Pro Ile Asp Ala Leu Ser Glu Asp Leu Asp Ser Cys Pro Pro Thr Thr 
         595                600                605
Glu Thr Ser Gln Asn Thr Thr Lys Glu Lys Gly Lys Lys Thr Ser Ser 
     610                615                620
Ser Lys Ala Ser Lys Asn Glu Glu Lys Thr Lys Asp Ser Ser Lys Lys 
 625                630                635                640
Thr Glu Glu Val Pro Lys Pro Lys Val Asp Glu Asp Ala Thr 
                 645                650



<210> 9642
<211> 2493
<212> DNA
<213> Homo sapiens
<308> D16217
<400> 9642

acattggta  ggtgttttc  cccattgaa  ctaatattt  ctattttca  gaaaaaagc  60
gcaagcctc  gcagcagtc  atcctccag  acctatgct  gtggaacag  ctcggccac  120
aaggtgtca  cttcctctg  tgcaaccag  aagtcttcc  gtatgaatc  cacagaaac  180
aaggccatt  cagtcagcc  acagatgga  ggaccacat  ttcctaaca  gaaaaaaca  240
aaaaaacag  ctgtaaaaa  agaacctga  aagaagtca  agtcaacca  gctgtctgt  300
gttcatgag  aaaaatccc  agaaggaaa  ccaaaagaa  acacagagc  aaaaagcct  360
cccaagcag  catcagata  aggaagtaa  gatgctcac  ataaaaaag  agtttccag  420
tcagctgaa  agcagccat  agagaaatc  acagaacca  agactaaac  acaagacat  480
atttctgct  gtggagaga  tgttgctgg  atcactgca  tatctggca  gccgggtga  540
aagaaaaaa  aaaagaaat  attaacccc  gctgtgcca  ttgaatcta  accggataa  600
ccatcggga  agtcaggca  ggatgctgc  ttggatgac  taatagata  tttaggagg  660
cctgaagaa  ctgaagaag  aaatacaac  tatactgga  cagaagttt  agatccaat  720
agttccacc  acatagagg  attgggtaa  agagaagtc  caattcctc  aaaatatag  780
gaactattg  ctaaaaagg  agggatcac  gggcctcct  cagactctt  aaaacccat  840
gggccagat  atgctatag  cgccttgtc  tctgacttc  cctgtgggt  gcctacagc  900
gctggaaag  aaactgaaa  agaggaatc  acagaagtt  taaaagctc  gtcagcagg  960
acagtcaga  gtgctgctc  accccaaga  aagaaaaga  aggtggaga  ggatacaat  1020
agtgatcaa  cactcgagg  tctgtcggc  tcactgggc  cccggcaag  agaacctga  1080
ctcgacctc  gctcaatta  ggaagtcga  gaggcaaaa  ctaaagaag  aaaactaga  1140
aagtgtggt  aggatgatg  aacaatccc  tctgagtac  gattaaaac  agccacgga  1200
aaagatgga  aaccactat  gccagagcc  gaagaaaaa  ccaagcctc  gagtgaatc  1260
gaactcatt  atgaacttt  agaagattt  gaccggtct  aatgtaaag  gaaaccatc  1320
aagccaact  aaaagacag  agaatctaa  gccgctgct  cagctcctg  gtcggaggc  1380
gtgtctcgg  cctccatgt  tagtataca  tcagcaccc  ctgagccgg  taccttgaa  1440
ggcacagtg  cagatgatg  tgtagaagc  ttggctgat  gcctgggga  aaaggaagc  1500
gatccagaa  atggaaaac  tgtgatgga  aaagtcaag  agaaggcca  agaagaaga  1560
cgtgaaaag  ttggtgaaa  agaagaaac  attcctcct  attatagat  agaagaggt  1620
aaggataaa  atggaaagc  actcctgcc  aaagagtct  aggaacagc  tccacccat  1680
agtgaagac  tccttctgg  tgctttgtc  gaggacttc  ctggtccac  aaatgcttc  1740
tctcttaaa  ttgaagatg  taaacttgc  gctgccatc  ctgaagtgg  ttcccaaac  1800
ccagcttca  cgacccaag  tggagcccc  ccccgtgat  cctcgcaga  tgacaaaga  1860
ctcgatgat  ccttggata  actctctga  agtctagga  aaaggcagc  tgacccaga  1920
gagaacaaa  caatgggag  taaagtaaa  gaaaaagct  aagctgaac  tagagacaa  1980
cttggagaa  gagatgaca  tatcccacc  gaatacaga  atctcctgg  tgataatgg  2040
caggacaaa  cagtgaagc  acctacaaa  aaatcagag  attcaaaga  acctgcaga  2100
gaccaagac  ccattgatg  tctctcagg  gatctggac  gctgtccct  cactacaga  2160
acctcacag  acacagcaa  ggataagtg  aagaaggct  cttccagct  caaagcacc  2220
aagaatgga  gtaaagcga  ggattcagc  aagacaaca  aggaaactt  caagccaaa  2280
gatgactaa  gaaatacaa  ttaaggtat  tggtatctg  atgtaaaat  ttcagctgg  2340
ggatggtga  ttttgaaga  caaaaggct  tggcaacag  aaacaattg  tctgggtga  2400
ttctagaat  gtttttgtt  agtctctga  catcctaaa  attggtttg  tattctttc  2460
agaaagaaa  tgaatttga  tggttcgga  ttc  2493



<210> 9643
<211> 708
<212> PRT
<213> Homo sapiens
<308> P20810
<400> 9643

Met Asn Pro Thr Glu Thr Lys Ala Ile Pro Val Ser Gln Gln Met Glu 
  1               5                  10                  15
Gly Pro His Leu Pro Asn Lys Lys Lys His Lys Lys Gln Ala Val Lys 
             20                  25                  30
Thr Glu Pro Glu Lys Lys Ser Gln Ser Thr Lys Leu Ser Val Val His 
         35                  40                  45
Glu Lys Lys Ser Gln Glu Gly Lys Pro Lys Glu His Thr Glu Pro Lys 
     50                  55                  60
Ser Leu Pro Lys Gln Ala Ser Asp Thr Gly Ser Asn Asp Ala His Asn 
 65                  70                  75                  80
Lys Lys Ala Val Ser Arg Ser Ala Glu Gln Gln Pro Ser Glu Lys Ser 
                 85                  90                  95
Thr Glu Pro Lys Thr Lys Pro Gln Asp Met Ile Ser Ala Gly Gly Glu 
             100                105                110
Ser Val Ala Gly Ile Thr Ala Ile Ser Gly Lys Pro Gly Asp Lys Lys 
         115                120                125
Lys Glu Lys Lys Ser Leu Thr Pro Ala Val Pro Val Glu Ser Lys Pro 
     130                135                140
Asp Lys Pro Ser Gly Lys Ser Gly Met Asp Ala Ala Leu Asp Asp Leu 
 145                150                155                160
Ile Asp Thr Leu Gly Gly Pro Glu Glu Thr Glu Glu Glu Asn Thr Thr 
                 165                170                175
Tyr Thr Gly Pro Glu Val Ser Asp Pro Met Ser Ser Thr Tyr Ile Glu 
             180                185                190
Glu Leu Gly Lys Arg Glu Val Thr Ile Pro Pro Lys Tyr Arg Glu Leu 
         195                200                205
Leu Ala Lys Lys Glu Gly Ile Thr Gly Pro Pro Ala Asp Ser Ser Lys 
     210                215                220
Pro Ile Gly Pro Asp Asp Ala Ile Asp Ala Leu Ser Ser Asp Phe Thr 
 225                230                235                240
Cys Gly Ser Pro Thr Ala Ala Gly Lys Lys Thr Glu Lys Glu Glu Ser 
                 245                250                255
Thr Glu Val Leu Lys Ala Gln Ser Ala Gly Thr Val Arg Ser Ala Ala 
             260                265                270
Pro Pro Gln Glu Lys Lys Arg Lys Val Glu Lys Asp Thr Met Ser Asp 
         275                280                285
Gln Ala Leu Glu Ala Leu Ser Ala Ser Leu Gly Thr Arg Gln Ala Glu 
     290                295                300
Pro Glu Leu Asp Leu Arg Ser Ile Lys Glu Val Asp Glu Ala Lys Ala 
 305                310                315                320
Lys Glu Glu Lys Leu Glu Lys Cys Gly Glu Asp Asp Glu Thr Ile Pro 
                 325                330                335
Ser Glu Tyr Arg Leu Lys Pro Ala Thr Asp Lys Asp Gly Lys Pro Leu 
             340                345                350
Leu Pro Glu Pro Glu Glu Lys Pro Lys Pro Arg Ser Glu Ser Glu Leu 
         355                360                365
Ile Asp Glu Leu Ser Glu Asp Phe Asp Arg Ser Glu Cys Lys Glu Lys 
     370                375                380
Pro Ser Lys Pro Thr Glu Lys Thr Glu Glu Ser Lys Ala Ala Ala Pro 
 385                390                395                400
Ala Pro Val Ser Glu Ala Val Ser Arg Thr Ser Met Cys Ser Ile Gln 
                 405                410                415
Ser Ala Pro Pro Glu Pro Ala Thr Leu Lys Gly Thr Val Pro Asp Asp 
             420                425                430
Ala Val Glu Ala Leu Ala Asp Ser Leu Gly Lys Lys Glu Ala Asp Pro 
         435                440                445
Glu Asp Gly Lys Pro Val Met Asp Lys Val Lys Glu Lys Ala Lys Glu 
     450                455                460
Glu Asp Arg Glu Lys Leu Gly Glu Lys Glu Glu Thr Ile Pro Pro Asp 
 465                470                475                480
Tyr Arg Leu Glu Glu Val Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro 
                 485                490                495
Lys Glu Ser Lys Glu Gln Leu Pro Pro Met Ser Glu Asp Phe Leu Leu 
             500                505                510
Asp Ala Leu Ser Glu Asp Phe Ser Gly Pro Gln Asn Ala Ser Ser Leu 
         515                520                525
Lys Phe Glu Asp Ala Lys Leu Ala Ala Ala Ile Ser Glu Val Val Ser 
     530                535                540
Gln Thr Pro Ala Ser Thr Thr Gln Ala Gly Ala Pro Pro Arg Asp Thr 
 545                550                555                560
Ser Gln Ser Asp Lys Asp Leu Asp Asp Ala Leu Asp Lys Leu Ser Asp 
                 565                570                575
Ser Leu Gly Gln Arg Gln Pro Asp Pro Asp Glu Asn Lys Pro Met Gly 
             580                585                590
Asp Lys Val Lys Glu Lys Ala Lys Ala Glu His Arg Asp Lys Leu Gly 
         595                600                605
Glu Arg Asp Asp Thr Ile Pro Pro Glu Tyr Arg His Leu Leu Asp Asp 
     610                615                620
Asn Gly Gln Asp Lys Pro Val Lys Pro Pro Thr Lys Lys Ser Glu Asp 
 625                630                635                640
Ser Lys Lys Pro Ala Asp Asp Gln Asp Pro Ile Asp Ala Leu Ser Gly 
                 645                650                655
Asp Leu Asp Ser Cys Pro Ser Thr Thr Glu Thr Ser Gln Asn Thr Ala 
             660                665                670
Lys Asp Lys Cys Lys Lys Ala Ala Ser Ser Ser Lys Ala Pro Lys Asn 
         675                680                685
Gly Gly Lys Ala Lys Asp Ser Ala Lys Thr Thr Glu Glu Thr Ser Lys 
     690                695                700
Pro Lys Asp Asp 
 705



<210> 9644
<211> 8221
<212> DNA
<213> Rattus norvegicus
<308> X57405
<400> 9644

ggcgggtca  ggagcgcag  ggcgtgggg  gcagggccg  gtgcagcgc  gtgaaggaa  60
gagcctggg  tgccctgta  tgccgggga  accctgaga  cccagcccg  ccacccgcc  120
ggaaagagg  cagcagcgg  tggaacgcc  gcgggaccg  ccgtggtgc  cgtgaacgt  180
cgatcccgg  cggccaccg  aagaggccg  cgcccggca  cgggcagct  gcgagcagg  240
atgccgcgg  tcctggcgc  cttgctctg  ctaacgctg  tgcccgcgc  cgccgcaag  300
ggcttgaga  gctcccagc  aagtgggac  tgcctgaat  gagggaggt  cgaagtggc  360
aacggcact  aagcctgtg  ctgcagcgg  gcgttcgtg  gccagcgat  ccaggaccc  420
agcccttgc  tcagcacac  atgtaagaa  gctggaacg  gctatgttg  ggaccatgg  480
ggcatcgtg  actatgcct  cagttgccc  ctgggtttc  ctgggcccc  ctgcctgac  540
cctctggcc  atgcctgcc  ggccaaccc  tgccgcaac  gggggacct  tgacctgct  600
actctcaca  aatacaagt  ccggtgccc  ccagggtgg  caggaaagt  atgtcagca  660
gccgacccc  gtgcctcca  cccctgtgc  aatggtggc  agtgcctgc  ctttgagtc  720
tcatacatc  gtggctgcc  gcccggctt  catggcccc  cctgcagac  agatgttaa  780
gagtgcagc  agaaccctg  gttgtgccg  catgggggc  cgtgccaca  tgagattgg  840
tcctatcgc  gtgcctgcc  tgccaccca  actggtccc  actgcgagc  gccctacgt  900
ccctgcagc  cctcaccct  ccagaacgg  ggcacctgc  gccctacgg  ggacaccac  960
cacgagtgt  cctgcctgc  aggctttgc  ggacagaac  gtgaagaaa  tgtggatga  1020
tgcccagga  acaactgca  gaacggggg  gcctgtgtg  acggtgtga  tacctacaa  1080
tgccgctgc  caccggagt  gacaggtca  tactgcaca  aggatgtgg  cgagtgtca  1140
ctcatgccc  acgcctgcc  gaatgcggg  acctgccac  actcccacg  tggctacaa  1200
tgcgtgtgt  tcaatggct  gactggtga  gactgcagt  acaacattg  tgactgtgc  1260
agtgccgcc  gttttcagg  tgccacctg  catgaccgt  tggcttcct  ctactgcga  1320
tgtccacat  ggcgcacag  cctgctgtg  cacctgaac  atgcgtgta  cagcaaccc  1380
tgcaacgag  gctccaact  cgacaccaa  cctgtcaac  gcaaggcca  ctgcacttg  1440
cctcggggg  acacggggc  agcctgcag  caggacgtg  atgagtgcg  tctaggtgc  1500
aacccgtgt  agcacgcgg  caagtgcct  aacacactg  gctctttcg  gtgtcagtg  1560
ctacagggc  acactgggc  ccgctgtga  attgatgtc  acgagtgca  ctccaaccc  1620
tgtcagaat  atgccacgt  cctggacca  attggggag  ttcagtgta  atgtatgcc  1680
ggttatgag  gtgtatact  tgagatcaa  acggacgag  gtgccagca  cccctgtct  1740
cacaatggc  gctgcgtgg  caagatcaa  gagttcctg  gtcagtgtc  caaaggctt  1800
agcgggcac  tgtgccagt  tgacgtgga  gagtgcgcc  gcacaccat  caagaacgg  1860
gccaagtgc  tggatgggc  caacaccta  acctgcgtg  gcacagaag  ttacacggg  1920
acccactgc  aggtggaca  tgacgagtg  gaccctgac  cctgtcaca  tggtttgtg  1980
aaggatggt  tggccacct  tacctgcct  tgccagcca  gctacacag  ccatcactg  2040
gagaccaac  ttaatgagt  tcacagcca  ccgtgccgc  atggcggca  ctgccagga  2100
cgtgacaac  actacctct  cttatgcct  aaggggacc  caggaccca  ctgtgagat  2160
aatctggat  actgtgcga  caacccctg  gactctggc  cgtgtctgg  caagatcga  2220
ggctacgag  gtgcgtgcg  gccaggcta  acagggagc  tgtgtaatg  caacattga  2280
gaatgtgcg  gcagcccct  ccacaacgg  ggcacctgt  aggatggca  cgccggctt  2340
acttgccgc  gccccgagg  ctaccacga  cctacgtgc  tgtctgagg  caacgagtg  2400
aacagtaac  cctgcatcc  tggagcttg  cgggatggc  tcaatggat  caaatgtga  2460
tgtgcccct  ggtggagtg  gacaaactg  gacatcaac  acaatgagt  tgagtccaa  2520
ccttgtgtc  acggtggca  ctgcaaaga  atgaccagt  gctacgtat  cacctgccg  2580
gaaggcttc  gtggcccta  ctgccagac  aacattaac  aatgtgctt  caacccctg  2640
ctgaaccag  gcacctgca  tgatgatgt  gctgggtac  aatgcaact  ccctctgcc  2700
tatacagga  ccacatgtg  ggtggtgtt  gccccatgt  ccaccagcc  ctgcaaaaa  2760
agtggggta  gcaaggagt  tgaggacta  gagagcttt  cctgtgtct  tcccacagg  2820
tggcaaggt  aaacctgcg  gatcgacat  aatgagtgt  tgaaaagcc  gtgtcgcca  2880
ggtgcctct  gccagaaca  caatggcag  taccgctgc  tctgccagg  tggctacac  2940
ggtcgcaac  gcgagagtg  catcgatga  tgccgaccc  acccatgtc  caacggggg  3000
tcctgcact  acggggtca  cgcggcctt  tgcgactgc  tgcccggct  ccagggtgc  3060
ttctgtgag  aggacatca  cgaatgcgc  acgaatcca  gccaaaatg  cgccaactg  3120
actgactgc  tggacagct  cacgtgcac  tgccccacc  ggttcaatg  catccattg  3180
gagaacaac  cacctgact  taccgagag  tcctgtttc  atggtggca  ctgtgtgga  3240
ggtatcaac  ccttcacct  tctgtgccc  cctggcttc  cgggcagct  ctgccagta  3300
gacgtcaat  agtgtgact  acggccctg  ctgcatggt  gcacctgcc  agacagcta  3360
ggtacctat  agtgtacct  cccacaggg  tacactggt  tcaactgcc  gaaccttgt  3420
cgctggtgt  actcagctc  ctgcaagaa  ggcggcaag  gctggcaga  caacacaca  3480
taccactgc  agtgccgca  cggctggac  ggcttcaac  gcgacgtgc  cagtgtgtc  3540
tgcgaggtg  ctgcacaga  gcgaggcat  gatgtcact  tcctatgcc  gcacggagg  3600
ctctgtgtg  atgaggaag  caagcatta  tgccactgc  aggcaggat  cacgggcag  3660
tactgtgag  acgaggtgg  cgagtgctc  cctaatccc  gccagaacg  agccacctg  3720
actgactat  tcggtggct  ttcctgcaa  tgtgtggct  ggtaccatg  ctctaactg  3780
tctgaggag  tcaacgagt  cctatccca  ccctgccag  atgggggta  ctgcattga  3840
ctgaccaac  cctacaagt  ctcctgccc  aggggcaca  agggtgtac  ctgtgagat  3900
aacgtcgat  actgccatc  tcccctaga  cctgcttcc  gaagcccca  atgcttcaa  3960
aatggcacc  gcgtggacc  ggtgggtgg  tatacctgc  cctgcccgc  aggcttcgt  4020
ggggagcgg  gcgagggcg  tgtcaatga  tgtctctcc  acccctgtg  cccacgtgg  4080
acccagaac  gcgtgcagc  tgttaatga  ttccactgc  agtgccggg  tggccacac  4140
ggacgccgc  gtgagtcgg  cattaatgg  tgcaggggc  aaccatgca  gaatggagg  4200
gtctgtgct  tggcctcca  caccgcccg  ggattcatc  gtaggtgcc  tgcccgctt  4260
gagggtgcc  cttgtgaaa  tgacgcccg  acttgtggc  gtttgcgct  cctcaacgg  4320
ggtacgtgc  tctcaggcc  acgcagtcc  acctgccta  gcctgggct  cttcactgg  4380
cctgaatgc  agttcccag  cagcagccc  tgtgtgggt  gcaacccct  ctacaatca  4440
ggcacctgt  agcccacat  cgagagccc  ttctaccgc  gtctatgcc  tgccaaatt  4500
aacgggctg  tgtgccaca  cctggacta  agcttcaca  gtgcggccg  gcgcgacat  4560
cccccgcca  agattgagg  ggcctgcga  ctgcctgag  gccaggagg  tgcaggcaa  4620
aaggtctgc  accttcagt  taataatca  gcgtgtggc  gggacggcg  cgactgctc  4680
ctcaacttc  atgaccctt  gaagaactg  actcagtcc  tgcagtgct  gaagtattt  4740
agtgacggc  actgtgaca  ccagtgcaa  tcagctggc  gcctttttg  tggcttcga  4800
tgccagctc  ccgagggac  gtgcaaccc  ctgtatgac  agtactgca  ggaccactt  4860
agtgatggc  actgcgacc  gggctgcaa  agtgccgag  gtgagtggg  tggactgga  4920
tgtgcagag  atgtccccg  gcgactggc  gccggcaca  tggtgctgg  ggtgctgct  4980
ccgcccgat  agctacgca  caactcctt  cacttcctg  gggacgtca  ccacgtgct  5040
cacaccaac  tggtcttca  gcgtgacgc  cagggccag  agatgatct  cccctacta  5100
ggccgcgag  aagagctac  caagcaccc  atcaagcgt  ctgcagtgg  ctgggccac  5160
acgtcactg  ttcctggca  caatggtgg  cgccagcgc  gggagctgg  ccccatgga  5220
atccatggc  ccatcgtct  cctggagat  gacaaccgg  agtgtgtac  gtcatcctc  5280
caatgcttc  agagcgcca  cgatgtggc  gccttccta  gtgctcttg  ctccctcgg  5340
agcctcaat  tcccctaca  gatcgaagc  gtaaagagt  agacggtgg  gcctccgct  5400
ccctcacag  tgcacctca  gtacgtggc  gcagctgcc  tcgtgctcc  gttctttgt  5460
ggctgtggg  tgctgctgt  ccgcaagcg  aggcggcag  atggccagc  ctggttccc  5520
gagggtttc  aagtgtcag  ggccagcaa  aagaagcgg  gagaacccc  cggcgagga  5580
tcagtcggc  tcaagcccc  gaagaacgc  tcagatggt  ccctgatgg  cgacaatca  5640
aacgagtgg  gggacgaag  cctggagac  aagaagttc  ggtttgagg  accagtggt  5700
ctccctgac  tggatgatc  gactgacca  cggcagtgg  cccagcagc  cctggatgc  5760
gctgaccta  gtgtgtctg  catggcccc  acgccgcct  agggggagg  agatgctga  5820
tgcatggac  tcaatgttc  aggaccaga  ggcttcact  ccctaatga  tgcctcctg  5880
agcggaggg  gcctggaga  aggcaacag  gaggaagaa  aagatgcac  tgctgtcat  5940
tccgacttc  tctatcagg  tgccagctt  cacaaccag  cggaccgca  aggggagac  6000
gccctgcac  tggctgccc  atactctcg  tcagatgct  ccaagcgct  gctggaggc  6060
agcgcagat  ccaacatcc  agacaacat  gggcgtacc  cattacatg  cgctgtttc  6120
gcagacgct  agggtgtct  ccagatcct  ctccggaac  gagccacag  tctggatgc  6180
cgaatgcat  atggcacaa  ccctctgat  ctggcggca  gcctggccg  ggaaggcat  6240
ctagaggac  tcatcaact  tcacgctga  gtcaatgct  tggatgacc  aggcaagtc  6300
gctctgcac  gggcagccg  tgtgaacaa  gtggacgct  ctgttgtgc  cctgaagaa  6360
ggagccaac  aagacatgc  gaacaacaa  gaggagact  ccctgttcc  ggccgcccg  6420
gagggcagc  atgagactg  caaagtgtt  ctggaccac  ttgccaacc  ggacatcac  6480
gatcacatg  accgattgc  acgggacat  gcacaggag  gcatgcacc  cgatatcgt  6540
cggcttttg  atgaataca  cctggtgcg  agcccacag  tgcatggca  tgccttggg  6600
ggcacaccc  ctctgtctc  cacactctg  tcgcccaac  gctacctgg  caacctcaa  6660
tctgccaca  agggcaaga  ggcccgaaa  cccagcacc  aagggctgg  ttgcagtag  6720
aaggaagct  aggacctca  ggcccggag  aagaagtcc  aggatggca  gggctgcct  6780
ttggacagc  caagcatgc  gtcacccgt  gactccctc  agtcacccc  tggctactt  6840
tcagatgtg  cctcaccac  cctccttcc  tccccgttc  agcagtctc  atccatgcc  6900
ctcagccac  tgccaggta  gcctgacac  cacctgggc  tcagccact  gaatgtggc  6960
gccaagccc  agatggcag  tctggccgg  ggcagccgg  tggcctttg  gccaccccc  7020
ccacgcctc  cccacctgc  tgtagcctc  agtgccagc  cagtgctga  taccaatgg  7080
acaggggct  tgaatttca  cgtgggtgc  ccggcaagc  tgaatggcc  gtgtgagtg  7140
cttccccgg  tccagaatg  catggtgcc  agccagtac  acccgctaa  gccaggtgt  7200
actccgggc  cactaagca  acaggcagc  ggcctccag  atggcatga  gggcccgat  7260
cacagcagc  tctccacca  taccttgtc  ccgattatc  accagggcc  gcccaacac  7320
aggctggcc  cacagcccc  cctggtgca  acccagcag  tgcagccac  gaacttaca  7380
atccagcct  agaacctgc  gccaccatc  cagccacac  tcagtgtga  ctcagcagc  7440
aatgggcac  tgggtcgga  cttcctgag  ggggagccc  gccaggcag  cgtacagcc  7500
ctgggcccc  gcagtctgc  tgtgcacac  attctgccc  aggaaagcc  ggctctgcc  7560
acatcactg  catcctcca  ggtcccacc  atgaccact  cccagttcc  gacccctcc  7620
tctcagcac  gctactcat  ctcacctgt  gacaacacc  ccagccacc  gctgcaggt  7680
ccagagcac  ccttcctca  cccatcccc  gagtcccct  accagtggt  cagctcctc  7740
cggcattcc  acatctctg  ttggtccga  ggcatctct  gcccgccca  gagcatgcc  7800
tcccagatc  cccacattc  agaggcatt  aagtaaaca  agatgtggg  tgaaggacc  7860
cagcttccg  tcccaagct  tgttgggag  cctttccag  gctccagga  gctggggcg  7920
ccaaaggag  cttttaaaa  aaaatgttt  tatacaaaa  aagaggaca  gaatttcca  7980
ttttttttt  gtatttatt  atgtacttt  attttccac  gaaacactg  ctttttatt  8040
atatgtatt  ttttctatg  cactagggg  aaacatctg  tccaagaaa  taaactagt  8100
ctgagagcc  cgattttcc  ggtcagggt  aagttccct  tgtgtttgt  aaatacgaa  8160
aaggattca  gatttgtaa  tgccgttta  ttattgatt  cttctttcc  aaatcgtcg  8220
g  8221



<210> 9645
<211> 2531
<212> PRT
<213> Rattus norvegicus
<308> CAA40667
<400> 9645

Met Pro Arg Leu Leu Ala Pro Leu Leu Cys Leu Thr Leu Leu Pro Ala 
  1               5                  10                  15
Leu Ala Ala Arg Gly Leu Arg Cys Ser Gln Pro Ser Gly Thr Cys Leu 
             20                  25                  30
Asn Gly Gly Arg Cys Glu Val Ala Asn Gly Thr Glu Ala Cys Val Cys 
         35                  40                  45
Ser Gly Ala Phe Val Gly Gln Arg Cys Gln Asp Pro Ser Pro Cys Leu 
     50                  55                  60
Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys Tyr Val Val Asp His Gly 
 65                  70                  75                  80
Gly Ile Val Asp Tyr Ala Cys Ser Cys Pro Leu Gly Phe Ser Gly Pro 
                 85                  90                  95
Leu Cys Leu Thr Pro Leu Ala Asn Ala Cys Leu Ala Asn Pro Cys Arg 
             100                105                110
Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
         115                120                125
Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
     130                135                140
Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ser 
 145                150                155                160
Ser Tyr Ile Cys Gly Cys Pro Pro Gly Phe His Gly Pro Thr Cys Arg 
                 165                170                175
Gln Asp Val Asn Glu Cys Ser Gln Asn Pro Gly Leu Cys Arg His Gly 
             180                185                190
Gly Thr Cys His Asn Glu Ile Gly Ser Tyr Arg Cys Ala Cys Arg Ala 
         195                200                205
Thr His Thr Gly Pro His Cys Glu Leu Pro Tyr Val Pro Cys Ser Pro 
     210                215                220
Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Thr Thr 
 225                230                235                240
His Glu Cys Ala Cys Leu Pro Gly Phe Ala Gly Gln Asn Cys Glu Glu 
                 245                250                255
Asn Val Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
             260                265                270
Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
         275                280                285
Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
     290                295                300
Ala Cys Gln Asn Ala Gly Thr Cys His Asn Ser His Gly Gly Tyr Asn 
 305                310                315                320
Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Asp Asn Ile 
                 325                330                335
Asp Asp Cys Ala Ser Ala Ala Cys Phe Gln Gly Ala Thr Cys His Asp 
             340                345                350
Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
         355                360                365
Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
     370                375                380
Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
 385                390                395                400
Pro Arg Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                 405                410                415
Ala Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Leu Asn Thr 
             420                425                430
Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
         435                440                445
Cys Glu Ile Asp Val Asn Glu Cys Ile Ser Asn Pro Cys Gln Asn Asp 
     450                455                460
Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
 465                470                475                480
Gly Tyr Glu Gly Val Tyr Cys Glu Ile Asn Thr Asp Glu Cys Ala Ser 
                 485                490                495
Ser Pro Cys Leu His Asn Gly Arg Cys Val Asp Lys Ile Asn Glu Phe 
             500                505                510
Leu Cys Gln Cys Pro Lys Gly Phe Ser Gly His Leu Cys Gln Tyr Asp 
         515                520                525
Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
     530                535                540
Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
 545                550                555                560
Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                 565                570                575
Ile Gly Leu Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Gln 
             580                585                590
Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys His 
         595                600                605
Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Tyr 
     610                615                620
Tyr Leu Cys Leu Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
 625                630                635                640
Asn Leu Asp Asp Cys Ala Ser Asn Pro Cys Asp Ser Gly Thr Cys Leu 
                 645                650                655
Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
             660                665                670
Ser Met Cys Asn Val Asn Ile Asp Glu Cys Ala Gly Ser Pro Cys His 
         675                680                685
Asn Gly Gly Thr Cys Glu Asp Gly Ile Ala Gly Phe Thr Cys Arg Cys 
     690                695                700
Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
 705                710                715                720
Asn Ser Asn Pro Cys Ile His Gly Ala Cys Arg Asp Gly Leu Asn Gly 
                 725                730                735
Tyr Lys Cys Asp Cys Ala Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
             740                745                750
Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
         755                760                765
Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
     770                775                780
Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
 785                790                795                800
Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                 805                810                815
Cys Pro Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
             820                825                830
Cys Ala Thr Ser Pro Cys Lys Asn Ser Gly Val Cys Lys Glu Ser Glu 
         835                840                845
Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
     850                855                860
Thr Cys Glu Ile Asp Ile Asn Glu Cys Val Lys Ser Pro Cys Arg His 
 865                870                875                880
Gly Ala Ser Cys Gln Asn Thr Asn Gly Ser Tyr Arg Cys Leu Cys Gln 
                 885                890                895
Ala Gly Tyr Thr Gly Arg Asn Cys Glu Ser Asp Ile Asp Asp Cys Arg 
             900                905                910
Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Val Asn Ala 
         915                920                925
Ala Phe Cys Asp Cys Leu Pro Gly Phe Gln Gly Ala Phe Cys Glu Glu 
     930                935                940
Asp Ile Asn Glu Cys Ala Thr Asn Pro Cys Gln Asn Gly Ala Asn Cys 
 945                950                955                960
Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Thr Gly Phe Asn 
                 965                970                975
Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
             980                985                990
Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser Phe Thr Cys Leu 
         995                1000                1005
Cys Pro Pro Gly Phe Thr Gly Ser Tyr Cys Gln Tyr Asp Val Asn Glu 
     1010                1015                1020
Cys Asp Ser Arg Pro Cys Leu His Gly Gly Thr Cys Gln Asp Ser Tyr 
 1025                1030                1035                1040
Gly Thr Tyr Lys Cys Thr Cys Pro Gln Gly Tyr Thr Gly Leu Asn Cys 
                 1045                1050                1055
Gln Asn Leu Val Arg Trp Cys Asp Ser Ala Pro Cys Lys Asn Gly Gly 
             1060                1065                1070
Lys Cys Trp Gln Thr Asn Thr Gln Tyr His Cys Glu Cys Arg Ser Gly 
         1075                1080                1085
Trp Thr Gly Phe Asn Cys Asp Val Leu Ser Val Ser Cys Glu Val Ala 
     1090                1095                1100
Ala Gln Lys Arg Gly Ile Asp Val Thr Leu Leu Cys Gln His Gly Gly 
 1105                1110                1115                1120
Leu Cys Val Asp Glu Glu Asp Lys His Tyr Cys His Cys Gln Ala Gly 
                 1125                1130                1135
Tyr Thr Gly Ser Tyr Cys Glu Asp Glu Val Asp Glu Cys Ser Pro Asn 
             1140                1145                1150
Pro Cys Gln Asn Gly Ala Thr Cys Thr Asp Tyr Leu Gly Gly Phe Ser 
         1155                1160                1165
Cys Lys Cys Val Ala Gly Tyr His Gly Ser Asn Cys Ser Glu Glu Ile 
     1170                1175                1180
Asn Glu Cys Leu Ser Gln Pro Cys Gln Asn Gly Gly Thr Cys Ile Asp 
 1185                1190                1195                1200
Leu Thr Asn Thr Tyr Lys Cys Ser Cys Pro Arg Gly Thr Gln Gly Val 
                 1205                1210                1215
His Cys Glu Ile Asn Val Asp Asp Cys His Pro Pro Leu Asp Pro Ala 
             1220                1225                1230
Ser Arg Ser Pro Lys Cys Phe Asn Asn Gly Thr Cys Val Asp Gln Val 
         1235                1240                1245
Gly Gly Tyr Thr Cys Thr Cys Pro Pro Gly Phe Val Gly Glu Arg Cys 
     1250                1255                1260
Glu Gly Asp Val Asn Glu Cys Leu Ser Asn Pro Cys Asp Pro Arg Gly 
 1265                1270                1275                1280
Thr Gln Asn Cys Val Gln Arg Val Asn Asp Phe His Cys Glu Cys Arg 
                 1285                1290                1295
Ala Gly His Thr Gly Arg Arg Cys Glu Ser Val Ile Asn Gly Cys Arg 
             1300                1305                1310
Gly Lys Pro Cys Arg Asn Gly Gly Val Cys Ala Val Ala Ser Asn Thr 
         1315                1320                1325
Ala Arg Gly Phe Ile Cys Arg Cys Pro Ala Arg Phe Glu Gly Ala Thr 
     1330                1335                1340
Cys Glu Asn Asp Ala Arg Thr Cys Gly Ser Leu Arg Cys Leu Asn Gly 
 1345                1350                1355                1360
Gly Thr Cys Ile Ser Gly Pro Arg Ser Pro Thr Cys Leu Cys Leu Gly 
                 1365                1370                1375
Ser Phe Thr Gly Pro Glu Cys Gln Phe Pro Ala Ser Ser Pro Cys Val 
             1380                1385                1390
Gly Ser Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro Thr Ser Glu 
         1395                1400                1405
Ser Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn Gly Leu Leu 
     1410                1415                1420
Cys His Ile Leu Asp Tyr Ser Phe Thr Gly Ala Ala Gly Arg Asp Ile 
 1425                1430                1435                1440
Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Glu 
                 1445                1450                1455
Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys 
             1460                1465                1470
Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys 
         1475                1480                1485
Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His 
     1490                1495                1500
Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp 
 1505                1510                1515                1520
Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys 
                 1525                1530                1535
Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala 
             1540                1545                1550
Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg 
         1555                1560                1565
Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln 
     1570                1575                1580
Leu Arg Asn Asn Ser Phe His Phe Leu Arg Asp Val Ser His Val Leu 
 1585                1590                1595                1600
His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile 
                 1605                1610                1615
Phe Pro Tyr Tyr Gly Arg Glu Glu Glu Leu Arg Lys His Pro Ile Lys 
             1620                1625                1630
Arg Ser Ala Val Gly Trp Ala Thr Thr Ser Leu Leu Pro Gly Thr Asn 
         1635                1640                1645
Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile His Gly Ser 
     1650                1655                1660
Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser 
 1665                1670                1675                1680
Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu 
                 1685                1690                1695
Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys 
             1700                1705                1710
Ser Glu Thr Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr 
         1715                1720                1725
Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val 
     1730                1735                1740
Leu Leu Ser Arg Lys Arg Arg Arg Gln His Gly Gln Leu Trp Phe Pro 
 1745                1750                1755                1760
Glu Gly Phe Lys Val Ser Glu Ala Ser Lys Lys Lys Arg Arg Glu Pro 
                 1765                1770                1775
Leu Gly Glu Asp Ser Val Gly Leu Lys Pro Leu Lys Asn Ala Ser Asp 
             1780                1785                1790
Gly Ala Leu Met Asp Asp Asn Gln Asn Glu Trp Gly Asp Glu Asp Leu 
         1795                1800                1805
Glu Thr Lys Lys Phe Arg Phe Glu Glu Pro Val Val Leu Pro Asp Leu 
     1810                1815                1820
Asp Asp Gln Thr Asp His Arg Gln Trp Thr Gln Gln His Leu Asp Ala 
 1825                1830                1835                1840
Ala Asp Leu Arg Val Ser Ala Met Ala Pro Thr Pro Pro Gln Gly Glu 
                 1845                1850                1855
Val Asp Ala Asp Cys Met Asp Val Asn Val Arg Gly Pro Asp Gly Phe 
             1860                1865                1870
Thr Pro Leu Met Ile Ala Ser Cys Ser Gly Gly Gly Leu Glu Thr Gly 
         1875                1880                1885
Asn Ser Glu Glu Glu Glu Asp Ala Pro Ala Val Ile Ser Asp Phe Ile 
     1890                1895                1900
Tyr Gln Gly Ala Ser Leu His Asn Gln Thr Asp Arg Thr Gly Glu Thr 
 1905                1910                1915                1920
Ala Leu His Leu Ala Ala Arg Tyr Ser Arg Ser Asp Ala Ala Lys Arg 
                 1925                1930                1935
Leu Leu Glu Ala Ser Ala Asp Ala Asn Ile Gln Asp Asn Met Gly Arg 
             1940                1945                1950
Thr Pro Leu His Ala Ala Val Ser Ala Asp Ala Gln Gly Val Phe Gln 
         1955                1960                1965
Ile Leu Leu Arg Asn Arg Ala Thr Asp Leu Asp Ala Arg Met His Asp 
     1970                1975                1980
Gly Thr Thr Pro Leu Ile Leu Ala Ala Arg Leu Ala Val Glu Gly Met 
 1985                1990                1995                2000
Leu Glu Asp Leu Ile Asn Ser His Ala Asp Val Asn Ala Val Asp Asp 
                 2005                2010                2015
Leu Gly Lys Ser Ala Leu His Trp Ala Ala Ala Val Asn Asn Val Asp 
             2020                2025                2030
Ala Ala Val Val Leu Leu Lys Asn Gly Ala Asn Lys Asp Met Gln Asn 
         2035                2040                2045
Asn Lys Glu Glu Thr Pro Leu Phe Leu Ala Ala Arg Glu Gly Ser Tyr 
     2050                2055                2060
Glu Thr Ala Lys Val Leu Leu Asp His Phe Ala Asn Arg Asp Ile Thr 
 2065                2070                2075                2080
Asp His Met Asp Arg Leu Pro Arg Asp Ile Ala Gln Glu Arg Met His 
                 2085                2090                2095
His Asp Ile Val Arg Leu Leu Asp Glu Tyr Asn Leu Val Arg Ser Pro 
             2100                2105                2110
Gln Leu His Gly Thr Ala Leu Gly Gly Thr Pro Thr Leu Ser Pro Thr 
         2115                2120                2125
Leu Cys Ser Pro Asn Gly Tyr Leu Gly Asn Leu Lys Ser Ala Thr Gln 
     2130                2135                2140
Gly Lys Lys Ala Arg Lys Pro Ser Thr Lys Gly Leu Ala Cys Ser Ser 
 2145                2150                2155                2160
Lys Glu Ala Lys Asp Leu Lys Ala Arg Arg Lys Lys Ser Gln Asp Gly 
                 2165                2170                2175
Lys Gly Cys Leu Leu Asp Ser Ser Ser Met Leu Ser Pro Val Asp Ser 
             2180                2185                2190
Leu Glu Ser Pro His Gly Tyr Leu Ser Asp Val Ala Ser Pro Pro Leu 
         2195                2200                2205
Leu Pro Ser Pro Phe Gln Gln Ser Pro Ser Met Pro Leu Ser His Leu 
     2210                2215                2220
Pro Gly Met Pro Asp Thr His Leu Gly Ile Ser His Leu Asn Val Ala 
 2225                2230                2235                2240
Ala Lys Pro Glu Met Ala Ala Leu Ala Gly Gly Ser Arg Leu Ala Phe 
                 2245                2250                2255
Glu Pro Pro Pro Pro Arg Leu Ser His Leu Pro Val Ala Ser Ser Ala 
             2260                2265                2270
Ser Thr Val Leu Ser Thr Asn Gly Thr Gly Ala Met Asn Phe Thr Val 
         2275                2280                2285
Gly Ala Pro Ala Ser Leu Asn Gly Gln Cys Glu Trp Leu Pro Arg Leu 
     2290                2295                2300
Gln Asn Gly Met Val Pro Ser Gln Tyr Asn Pro Leu Arg Pro Gly Val 
 2305                2310                2315                2320
Thr Pro Gly Thr Leu Ser Thr Gln Ala Ala Gly Leu Gln His Gly Met 
                 2325                2330                2335
Met Gly Pro Ile His Ser Ser Leu Ser Thr Asn Thr Leu Ser Pro Ile 
             2340                2345                2350
Ile Tyr Gln Gly Leu Pro Asn Thr Arg Leu Ala Thr Gln Pro His Leu 
         2355                2360                2365
Val Gln Thr Gln Gln Val Gln Pro Gln Asn Leu Gln Ile Gln Pro Gln 
     2370                2375                2380
Asn Leu Gln Pro Pro Ser Gln Pro His Leu Ser Val Ser Ser Ala Ala 
 2385                2390                2395                2400
Asn Gly His Leu Gly Arg Ser Phe Leu Ser Gly Glu Pro Ser Gln Ala 
                 2405                2410                2415
Asp Val Gln Pro Leu Gly Pro Ser Ser Leu Pro Val His Thr Ile Leu 
             2420                2425                2430
Pro Gln Glu Ser Gln Ala Leu Pro Thr Ser Leu Pro Ser Ser Met Val 
         2435                2440                2445
Pro Pro Met Thr Thr Thr Gln Phe Leu Thr Pro Pro Ser Gln His Ser 
     2450                2455                2460
Tyr Ser Ser Ser Pro Val Asp Asn Thr Pro Ser His Gln Leu Gln Val 
 2465                2470                2475                2480
Pro Glu His Pro Phe Leu Thr Pro Ser Pro Glu Ser Pro Asp Gln Trp 
                 2485                2490                2495
Ser Ser Ser Ser Arg His Ser Asn Ile Ser Asp Trp Ser Glu Gly Ile 
             2500                2505                2510
Ser Ser Pro Pro Thr Ser Met Pro Ser Gln Ile Thr His Ile Pro Glu 
         2515                2520                2525
Ala Phe Lys 
     2530



<210> 9646
<211> 11395
<212> DNA
<213> Homo sapiens
<308> XM_034671
<400> 9646

tttcagcca  acttcgggc  gcggctgag  cggcggccg  ggagcggcg  actcggggc  60
cggggagtc  aggcatttg  gcctgggct  cggagcgta  cgccagggc  tgagccttt  120
aagcaggag  aggggagga  agagtgggg  tcctctatc  ggaccccct  cccatgtgg  180
tctgcccag  cggcggcgg  ggcggcgga  gaggaggcg  ccgagaaga  gcccgccct  240
cgccccgct  tgctgtggg  gctgctggc  ctctggctg  gctgcgcgg  ccccgcgca  300
gcattgcag  gtcgagatg  ctatgaacc  tgtgtaaat  aaggaatgt  tgttaccta  360
cacaatggc  caggatact  caaatgtcc  gaaggcttc  tgggggaat  ttgtcaaca  420
cgagacccc  gtgagaaga  ccgctgcca  aatggtggg  cttgtgtgg  ccaggccat  480
ctggggaaa  ccacgtgcc  atgtgcctc  gggtttaca  gagaggact  ccagtactc  540
acatctcat  catgctttg  gtctcgacc  tgcctgaat  gcggcacat  ccatatgct  600
agccgggat  cctatgagt  cacctgtca  gtcgggttt  caggtaagg  gtgccaatg  660
acggatgcc  gcctgtctc  tccctgtgc  aatggaagt  cctgtacca  tgtggccaa  720
cagttctcc  gcaaatgcc  cacaggctt  acagggcag  aatgtgaga  tgatgtcaa  780
gagtgtgac  ttccaggac  ctgccagca  ggtggcacc  gcctcaacc  gcctggttc  840
taccagtgc  agtgccctc  gggcttcac  ggccagtac  gtgacagcc  gtatgtgcc  900
tgtgcaccc  caccttgtg  caatggagg  acctgtcgg  agactggtg  cttcacttt  960
gagtgcaac  gccttccag  ttttgaagg  agcacctgt  agaggaata  tgatgactg  1020
cctaaccac  ggtgtcaga  tggaggggt  tgtgtggat  gggtcaaca  ttacaactg  1080
cgctgtccc  cacaatgga  aggacagtt  tgcacagag  atgtggatg  atgcctgct  1140
cagcccaat  cctgtcaaa  tgggggcac  tgtgccaac  gcaatggag  ctatggctg  1200
gtatgtgtc  acggctgga  tggagatga  tgcagtgag  acattgatg  ttgtgcctt  1260
gcctcctgt  ctccaggct  cacctgcat  gaccgtgtg  cctccttct  ttgcatgtg  1320
ccagagggg  aggcaggtc  cctgtgtca  ctggatgat  catgcatca  caatccttg  1380
cacaagggg  cactgtgtg  caccaaccc  ctaaatggg  aatatattt  cacctgccc  1440
caaggctac  aaggggctg  ctgcacaga  gatgtggat  aatgtgcca  ggccaatag  1500
aatccttgt  agcatgcag  aaaatgtgt  aacacggat  gcgccttcc  ctgtgagtg  1560
ctgaagggt  atgcaggac  tcgttgtga  atggacatc  atgagtgcc  ttcagaccc  1620
tgccagaat  atgctacct  tctggataa  attggaggc  tcacatgtc  gtgcatgcc  1680
ggtttcaaa  gtgtgcatt  tgaattaga  ataaatgaa  gtcagagca  cccttgtgt  1740
aacaatggg  agtgtgtgg  taaagtcaa  cgtttccag  gcctgtgtc  tcctggttt  1800
actgggcca  tttgccaga  tgatattga  gactgttcc  gtactccgt  tctgaatgg  1860
gcaaagtgt  tcgatcacc  gaatggcta  gaatgccag  gtgccacag  tttcactgg  1920
gtgttgtgt  aggagaaca  tgacaactg  gaccccgat  cttgccacc  tggtcagtg  1980
caggatggt  ttgattcct  cacctgcat  tgcaatccc  ggtacatgg  cgccatctg  2040
agtgaccag  ttgatgaat  ttacagcag  ccttgcctg  acgatggtc  ctgcattga  2100
ctggtcaat  gctaccagt  caactgcca  ccaggcacg  caggggtta  ttgtgaaat  2160
aattttgat  actgtgcaa  taacccttg  atccatgga  tctgtatgg  tggcattaa  2220
cgctacagt  gtgtctgct  accaggatt  acagggcag  gatgtaaca  tgacattga  2280
gagtgtgcc  ccaatccct  tcgcaaggg  gcaacatgt  tcaacggtg  gaatggttt  2340
cgctgtata  gccccgagg  accccatca  cccagctgc  actcacagg  gaacgaatg  2400
ctgagcaat  cctgcatcc  tggaaactg  actggaggt  tcagtggat  taagtgtct  2460
tgtgatgca  gctgggttg  catcaactg  gaagtggac  aaaatgaat  cctttcgaa  2520
ccatgccag  atggaggaa  ttgtgacaa  ctggtgaat  gatacaggt  tacttgcaa  2580
aagggcttt  aaggctata  ctgccaggt  aatattgat  aatgtgcct  aaatccatg  2640
ctgaaccaa  gaacctgct  tgatgacat  agtggctac  cttgccact  tgtgctgcc  2700
tacacaggc  agaattgtc  gacagtatt  gctccctgt  ccccaaacc  ttgtgagaa  2760
gctgctgtt  gcaaagagt  accaaattt  gagagttat  cttgcttgt  tgctcctgg  2820
tggcaaggt  agcggtgta  cattgacat  gacgagtgt  tctccaagc  ctgcatgaa  2880
catggtctc  gccataaca  ccagggcag  tacatgtgt  aatgtccac  aggcttcag  2940
ggtatggac  gtgaggagg  cattgatga  tgccttgcc  atccttgcc  gaatggagg  3000
tcctgtatg  atggagtga  tactttctc  tgcctctgc  ttccgggtt  cactgggga  3060
aagtgccag  cagacatga  tgagtgtct  agtgaaccc  gtaagaatg  agggacctg  3120
tctgactac  tcaacagtt  cacttgcaa  tgccaggca  gatttgatg  agtccattg  3180
gagaacaac  tcaatgagt  cactgagag  tcctgtttc  atggtggca  atgtgttga  3240
gggattaac  ccttctctt  cttgtgccc  gtgggtttc  ctggatcct  ctgcctcca  3300
gagatcaat  aatgcagct  tcatccatg  ctgaatgag  gaacgtgtg  tgatggcct  3360
ggtacctac  gctgcagct  ccccctggg  tacactggg  aaaactgtc  gaccctggt  3420
aatctctgc  gtcggtctc  atgtaaaaa  aaaggtact  gcgttcaga  aaaagcaga  3480
tcccagtgc  tatgtccat  tggatgggc  ggtgcctat  gtgacgtgc  caatgtctc  3540
tgtgacata  cagcctcca  gagaggtgt  cttgttgaa  acttgtgcc  gcactcagg  3600
gtctgcatc  atgctggca  cacgcatta  tgtcagtgc  ccctgggct  tactgggag  3660
tactgtgag  agcaactcg  tgagtgtgc  tccaacccc  gccagcacg  ggcaacatg  3720
agtgacttc  ttggtggat  cagatgcga  tgtgtccca  gctatcagg  tgtcaactg  3780
gagtatgaa  tggatgagt  ccagaatca  ccctgccag  atggaggca  ctgtattga  3840
cttgtgaac  atttcaagt  ctcttgccc  ccaggcact  ggggcctac  ctgtgaaga  3900
aacattgat  actgtgccc  gggtcccca  tgccttaat  gtggtcagt  catggatag  3960
attggaggc  acagttgtc  ctgcttgcc  ggctttgct  gggagcgtt  tgagggaga  4020
atcaacgag  gcctctcca  cccctgcag  tctgagggc  gcctggact  tatacagct  4080
accaatgac  acctgtgtg  ttgccgtag  gcctttact  gccggcact  tgaaacctt  4140
gtcgatgtg  gtccccaga  gccctgcct  aatggaggg  cttgtgctg  ggccagtaa  4200
atgcctgat  gtttcattt  ccgttgtcc  ccgggattt  ccggggcaa  gtgccagag  4260
agctgtgga  aagtgaaat  taggaaggg  gagcagtgt  tgcacaccg  ctctggacc  4320
cgctgcttc  gccccagtc  ccgggactg  gagtcaggc  gtgccagta  cccctgcca  4380
cacgggggc  gctgccacc  tcagcgcca  cctccttat  actcctgcc  gtgtgcccc  4440
ccattctcg  gtagccgct  tgaactcta  acggcaccc  ccagcaccc  tcctgccac  4500
tgtctgagc  agtattgtg  cgacaaagc  cgggatggc  tctgtgatg  ggcctgcaa  4560
agccatgcc  gccagtggg  tgggggtga  tgttctctc  ccatggaga  cccctgggc  4620
aactgctcc  ccccacttc  ctgctggga  tatatcaac  accagtgtg  tgagctgtg  4680
aacacggtc  agtgcctgt  tgacaactt  gaatgccag  ggaacagca  gacatgcaa  4740
tatgacaaa  actgtgcag  ccacttcaa  gacaaccac  gtgaccagg  gtgcaacag  4800
gaggagtgt  gttgggatg  gctggactg  gctgctgac  aacctgaga  cctggcaga  4860
ggtaccctg  ttattgtgg  attgatgcc  cctgaacaa  tgctccagg  tgctcgcag  4920
ttcttgcgg  cactgggta  cctgctcca  accaacctg  gcattaagc  ggactccca  4980
ggggaactc  tggtgtacc  ctattatgg  gagaagtca  ctgctatga  gaaacagag  5040
atgacacgc  gatcccttc  tggtgaaca  gaacaggag  tggctggct  taaagtctt  5100
ctggaaatt  acaaccgcc  gtgtgttca  gactcagac  actgcttca  gaacacgga  5160
gcagcagca  ctctcctgg  ctctcacgc  atacagggg  ccctgtcat  ccctcttgt  5220
tctgtcgtc  gtgaatccc  gactccaga  cgcactcag  tcctctatc  ccttgctgt  5280
gctgttgtc  tcattctgt  tattattct  ctgggggta  tcatggcaa  acgaaagcg  5340
aagcatggc  ctctctggc  gcctgaagg  ttcactctt  gccgagatg  aagcaatca  5400
aagcgtcgt  agccagtgg  acaggatgc  gtggggctg  aaaatctct  agtgcaagt  5460
tcagaagct  acctaattg  tactggaac  agtgaacac  gggtcgatg  tgaagggcc  5520
cagccaaag  aagtaaagg  tgaagatga  gccttactc  cagaagaag  tgaccccat  5580
gatcgacgg  catggacac  gcagcacct  gaagctgca  acatccgta  gacaccatc  5640
ctggctctc  cccctcctc  ggcagagca  gaggtggat  tgttagatg  gaatgtccg  5700
ggcccagat  gctgcaccc  attgatgtt  gcttctctc  gaggaggca  ctcagattt  5760
agtgatgaa  atgaagatg  agaggactc  tctgctaac  tcatcacag  cttggtcta  5820
cagggtgcc  gcctccagg  ccagacaga  cggactggt  agatggccc  gcaccttgc  5880
gcccgctac  cacgggctg  tgctgccaa  cgtctcctg  atgcaggtg  agatgccaa  5940
gcccaggac  acatgggcc  ctgtccact  catgctgca  tggcagctg  tgcccaagg  6000
gtcttccag  ttctgattc  caaccgagt  actgatcta  atgccagga  gaatgatgg  6060
actacaccc  tgatcctgg  tgcccgcct  gctgtggag  gaatggtgg  agaactgat  6120
aactgccaa  cggatgtga  tgcagtgga  gaccatgga  aatctgctc  tcactgggc  6180
gctgctgtc  ataatgtgg  ggcaactct  ttgttgttg  aaaatgggg  caaccgaga  6240
atgcaggac  acaaggaag  gacacctct  tttcttgct  cccgggagg  gagctatga  6300
gcagccaag  tcctgttag  ccattttgc  aatcgagac  tcacagacc  tatggatcg  6360
cttccccgg  atgtggctc  ggatcgcat  caccatgac  ttgtgcgcc  tctggatga  6420
tacaatgtg  ccccaagcc  tccaggcac  gtgttgact  ctgctctct  acctgtcat  6480
tgtgggccc  acagatctt  cctcagcct  aagcacacc  caatgggca  gaagtctag  6540
cggcccagt  ccaagagta  catgcctac  agcctccct  accttgcca  ggaggcaaa  6600
gatgccaag  gtagtagga  gaagaagtc  ctgagtgag  aggtccaac  gtctgagag  6660
tcagtaact  tatcccctg  tgattccct  gaatctcct  acacgtatg  ttccgacac  6720
acatcctct  caatgatta  atcccctgg  atcttacag  cctcaccca  ccctatgtt  6780
gccactgcc  cccctcctg  cccagtcca  gcccagcat  cactatctt  ttctaacct  6840
catgaaatg  agcctttgg  acatggggc  agcactgtg  ttccctcag  gagccagtt  6900
ctatcccac  accacattg  gtctccagg  agtggcagt  ctggaagct  gagtaggct  6960
catccagtc  cagtcccag  agattggat  aaccgcatg  aggtgaatg  gacccagta  7020
aatgagatg  ttggtatgg  cctggctcc  gctgagggc  cccatcctg  catagctcc  7080
cagagcagg  cacctgaag  gaagcacat  accacccct  gggagccct  gccccccat  7140
gtgactttc  agctcatcc  taaaggcag  attgcccaa  cagcggggg  tccccagcc  7200
cagtccacc  gccctccag  tgttgcggg  cccctgccc  ccatgtacc  gattccaga  7260
atggcccgt  tgcccagtg  ggctttccc  actgccatg  tgccccagc  ggacgggca  7320
gtagctcag  ccattctcc  agcctatca  cctttccca  cctctgtgg  caagtaccc  7380
acaccccct  cacagcaca  ttatgcttc  tcaaatgct  ctgagcgaa  acccagtca  7440
agtggtcac  tccagggtg  gcatcccta  ctgacacca  ccccagagt  tcctgacca  7500
tggtcaagt  catcacccc  ctctgcttc  gactggtca  atgtgacca  cagccctac  7560
cctgggggt  ctggaggag  tcagcgggg  cctgggaca  acatgtctg  gccaccaca  7620
aacaacatg  aggtttatg  gtgagagag  ccacctcca  tgtagagac  taactgact  7680
ttgtaaatg  tgctgagga  caaatgaag  tcatccggg  gagaaatga  gaaatctct  7740
gagccagct  ctagaggta  gaaagagaa  atgttctta  tcagataat  caagagaag  7800
aattcgtca  tttcactgg  tatctgcaa  gcttattga  tattctaat  taataagac  7860
agtttgtgg  aatgcaaga  gaatacaag  cttgggtcc  tgtttactc  cttctattt  7920
gagaataag  tggatgctt  ttgaagccc  gacattctt  cagcttgga  tgcatttta  7980
gccctgcag  cttctgcca  atccatgag  agattctac  ctagcgtcc  gttgggaat  8040
atgccctgg  attctgcct  aattgacct  cgcatctcc  cctccttgg  cattctttt  8100
tcttcattt  gtgcttttg  ttttgcacc  ctccgtgat  gtagcccta  cagcatgtt  8160
tagggcaag  cctttgtgc  tttgatcat  ctggcccat  aaagcaact  tggtctcct  8220
tcccctcct  tcttcccgg  atcccttgg  gtctcacaa  gtttacttt  gtatggttc  8280
cagcacaaa  ctttcaagt  tgttgtttc  ttggaaaat  gacatactg  attgtgttc  8340
cctgcatat  tcattcctg  agagagaag  ggagaagaa  acttttctt  aacaaattt  8400
gggggcagg  gatcccttc  agaggctgc  ccttaattt  tcttgtctg  gtgcaggtc  8460
tcatataaa  tttaccagg  agaagggtg  gagtttgtt  tttttctgt  tatgggcct  8520
gtcagtgta  agttttatc  ttgatagtc  agttactat  accctcccc  cttttttaa  8580
accagaaaa  ggtttggaa  gttggaatg  ccaagagac  agttaactc  tgcaagagc  8640
agttaccca  ccacaggtc  ccctacttc  tgccaagca  tccattgac  gcctgtatg  8700
aacacattt  tcccagatc  gagcattct  ggcctgttt  actcactca  ccagcatat  8760
aaactagtc  taactgttg  gcctttcct  tcatatcca  agaagacac  gtctcaaat  8820
ttgtaccct  gccatttag  actgaactt  ccttagccc  agggaccca  tgacagttg  8880
cttccgttt  tcagatgat  agtctctac  gattatctt  ctgcttaaa  gcctgctca  8940
caatctttc  ttcacaccg  gtggtccgt  ttactggta  acccagtat  ttctcactg  9000
agacatgga  tttatatgt  caagtgcag  aattggaaa  ttggacttg  tttctatga  9060
ccaaaacag  cctataaga  ggttggaaa  ggaggaact  tatagcagc  tttgctatt  9120
tctgctacc  tttcttttc  tctgaagcg  ccatgacat  ccctttggc  actaacgta  9180
aaactcaac  gaacatttt  ctttcctag  gtcaccttt  agatgataa  ggacaacta  9240
agacttgct  attgttcag  ctgattgcc  ctcacctga  tccactctc  gtattcatg  9300
tcttggcaa  ttctttgac  ttcttttaa  ggcagaagc  ttttagtta  ttgtagata  9360
agaatagtt  tcttcctct  ctccttggg  cagttaata  ttggtccat  gctacactg  9420
aacttccgt  cagtgctgt  atgcccatg  cacctgcaa  ataagttct  cctgggcat  9480
ttgtagata  taacaggtg  attcccgac  cttttggtt  gaatgacag  tctcattcc  9540
tctatggct  caagtatgc  tcagtgctt  ccacttacc  gatttgtct  tcggtggcc  9600
catatggaa  ccctgcgtg  ctgttggca  aatagttta  aaatggttt  ttcagtcct  9660
tccaaattt  ttgaaccaa  aaaaataat  acttctgcc  tgagataag  agattaagt  9720
tgttcattc  ctgctttat  ctctccatg  ggcaacatt  tgtcagcct  tttcatagt  9780
tgcaaacat  ttatcattc  aaatggtga  tctctgccc  tggacccat  tattattca  9840
agatgggga  aacctatct  catggacct  tgtggacca  agcgtacct  cccctttct  9900
ccctcctgc  ccagcccca  ttctgaaag  atcagctac  gatccagcc  ctggatatt  9960
tatatcctc  cttttcctt  agcacaatg  cagaccaaa  tgcttgttt  tttttcttg  10020
actacttta  tttggatcc  ttgggtttg  agaaaggga  tgtgaaagc  gtcattaca  10080
acaacaggt  tcagtgatg  ggaggacaa  actgccttt  aaacttttt  ctgatctct  10140
agattttaa  aactcttga  ttgtgtggt  tctaataaa  gggaaggta  gatggataa  10200
cactttctc  tttgggttc  gaattggag  ctcagtttt  atgagacac  tcttttatg  10260
catgtatag  tcctcccct  ctatttttg  tttattttt  ttgttataa  tgctttctt  10320
ctttgactc  tcttctgcc  gcctttggg  ataggtttt  ttgtttgtt  atttgcttc  10380
tctgttttg  tttaagcat  attttctta  gtgaggtgg  gaagggaaa  gtatgaggg  10440
aagagagtc  gagaattaa  atattttag  ataagcaat  ggctgtgat  ctcaaatcc  10500
ttgcatcct  ttattgaat  tgccaattt  taatttttg  ataataaag  accaaaggt  10560
taatgtttt  ttgagaggt  gtttaggga  tttggccct  accaataca  tgaatgtat  10620
atgactatt  gggaggaca  atttatgta  ccagaggcc  ccactaata  gtggtacta  10680
ggttacttc  ttgtgtaca  ttctcttaa  agtgatatt  tatctgttt  tatgagaaa  10740
ccagtaacc  ataaaatga  cgcatattc  tgactaaac  tagtaagga  aatgcacac  10800
ttgttttta  ttttccgtt  cattctaaa  gtagttaag  tgaaattta  atgaaagca  10860
ttttatcac  aaataaaaa  ggtttgcca  gctcagtgg  gttgtattt  ttattttcc  10920
atactgcat  catggcctg  cagtgttac  tcatgatgt  ataatttgc  gagagagca  10980
attttcttt  ctttctgaa  cccacaaag  ctagcacca  acttctttt  ttcttcctt  11040
aattagatc  taaataaat  atcctgggg  aaaagcatc  gtcaaatag  aaacatcac  11100
aaactgagc  ctcttctgt  cactagcca  agctggtga  aaacagatg  ttgctcagg  11160
acaaggtgc  ttccaatgg  aatgcgaag  agttgctat  gcaagaatt  ggaactggg  11220
tataagtca  aatattaat  atgctgtta  gtaaatgat  ggtttgtaa  attccttaa  11280
tgaaatttg  gtagaactt  atatacagg  ttataaaat  atattttgt  tataaattt  11340
ttataagtt  acattcata  atttattta  aaagtcagt  agatatttg  acatg  11395



<210> 9647
<211> 2471
<212> PRT
<213> Homo sapiens
<308> XP_034671
<400> 9647

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
  1               5                  10                  15
Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
             20                  25                  30
Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
         35                  40                  45
Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
     50                  55                  60
Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
 65                  70                  75                  80
Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                 85                  90                  95
Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
             100                105                110
Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
         115                120                125
Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
     130                135                140
Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
 145                150                155                160
Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                 165                170                175
Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
             180                185                190
Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
         195                200                205
Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
     210                215                220
Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
 225                230                235                240
Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                 245                250                255
Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
             260                265                270
Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
         275                280                285
Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
     290                295                300
Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
 305                310                315                320
Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                 325                330                335
Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
             340                345                350
Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
         355                360                365
Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
     370                375                380
His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
 385                390                395                400
Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                 405                410                415
Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
             420                425                430
Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
         435                440                445
Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
     450                455                460
Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
 465                470                475                480
Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                 485                490                495
Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
             500                505                510
Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
         515                520                525
Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
     530                535                540
Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
 545                550                555                560
Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                 565                570                575
Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
             580                585                590
Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
         595                600                605
Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
     610                615                620
Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
 625                630                635                640
Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                 645                650                655
Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
             660                665                670
Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
         675                680                685
Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
     690                695                700
Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
 705                710                715                720
Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                 725                730                735
Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
             740                745                750
Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
         755                760                765
Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
     770                775                780
Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
 785                790                795                800
Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                 805                810                815
Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
             820                825                830
Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
         835                840                845
Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
     850                855                860
Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
 865                870                875                880
Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                 885                890                895
Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
             900                905                910
Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
         915                920                925
Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
     930                935                940
Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
 945                950                955                960
Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                 965                970                975
Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
             980                985                990
Glu Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser 
         995                1000                1005
Phe Ser Cys Leu Cys Pro Val Gly Phe Thr Gly Ser Phe Cys Leu His 
     1010                1015                1020
Glu Ile Asn Glu Cys Ser Ser His Pro Cys Leu Asn Glu Gly Thr Cys 
 1025                1030                1035                1040
Val Asp Gly Leu Gly Thr Tyr Arg Cys Ser Cys Pro Leu Gly Tyr Thr 
                 1045                1050                1055
Gly Lys Asn Cys Gln Thr Leu Val Asn Leu Cys Ser Arg Ser Pro Cys 
             1060                1065                1070
Lys Asn Lys Gly Thr Cys Val Gln Lys Lys Ala Glu Ser Gln Cys Leu 
         1075                1080                1085
Cys Pro Ser Gly Trp Ala Gly Ala Tyr Cys Asp Val Pro Asn Val Ser 
     1090                1095                1100
Cys Asp Ile Ala Ala Ser Arg Arg Gly Val Leu Val Glu His Leu Cys 
 1105                1110                1115                1120
Gln His Ser Gly Val Cys Ile Asn Ala Gly Asn Thr His Tyr Cys Gln 
                 1125                1130                1135
Cys Pro Leu Gly Tyr Thr Gly Ser Tyr Cys Glu Glu Gln Leu Asp Glu 
             1140                1145                1150
Cys Ala Ser Asn Pro Cys Gln His Gly Ala Thr Cys Ser Asp Phe Ile 
         1155                1160                1165
Gly Gly Tyr Arg Cys Glu Cys Val Pro Gly Tyr Gln Gly Val Asn Cys 
     1170                1175                1180
Glu Tyr Glu Val Asp Glu Cys Gln Asn Gln Pro Cys Gln Asn Gly Gly 
 1185                1190                1195                1200
Thr Cys Ile Asp Leu Val Asn His Phe Lys Cys Ser Cys Pro Pro Gly 
                 1205                1210                1215
Thr Arg Gly Leu Leu Cys Glu Glu Asn Ile Asp Asp Cys Ala Arg Gly 
             1220                1225                1230
Pro His Cys Leu Asn Gly Gly Gln Cys Met Asp Arg Ile Gly Gly Tyr 
         1235                1240                1245
Ser Cys Arg Cys Leu Pro Gly Phe Ala Gly Glu Arg Cys Glu Gly Asp 
     1250                1255                1260
Ile Asn Glu Cys Leu Ser Asn Pro Cys Ser Ser Glu Gly Ser Leu Asp 
 1265                1270                1275                1280
Cys Ile Gln Leu Thr Asn Asp Tyr Leu Cys Val Cys Arg Ser Ala Phe 
                 1285                1290                1295
Thr Gly Arg His Cys Glu Thr Phe Val Asp Val Cys Pro Gln Met Pro 
             1300                1305                1310
Cys Leu Asn Gly Gly Thr Cys Ala Val Ala Ser Asn Met Pro Asp Gly 
         1315                1320                1325
Phe Ile Cys Arg Cys Pro Pro Gly Phe Ser Gly Ala Arg Cys Gln Ser 
     1330                1335                1340
Ser Cys Gly Gln Val Lys Cys Arg Lys Gly Glu Gln Cys Val His Thr 
 1345                1350                1355                1360
Ala Ser Gly Pro Arg Cys Phe Cys Pro Ser Pro Arg Asp Cys Glu Ser 
                 1365                1370                1375
Gly Cys Ala Ser Ser Pro Cys Gln His Gly Gly Ser Cys His Pro Gln 
             1380                1385                1390
Arg Gln Pro Pro Tyr Tyr Ser Cys Gln Cys Ala Pro Pro Phe Ser Gly 
         1395                1400                1405
Ser Arg Cys Glu Leu Tyr Thr Ala Pro Pro Ser Thr Pro Pro Ala Thr 
     1410                1415                1420
Cys Leu Ser Gln Tyr Cys Ala Asp Lys Ala Arg Asp Gly Val Cys Asp 
 1425                1430                1435                1440
Glu Ala Cys Asn Ser His Ala Cys Gln Trp Asp Gly Gly Asp Cys Ser 
                 1445                1450                1455
Leu Thr Met Glu Asn Pro Trp Ala Asn Cys Ser Ser Pro Leu Pro Cys 
             1460                1465                1470
Trp Asp Tyr Ile Asn Asn Gln Cys Asp Glu Leu Cys Asn Thr Val Glu 
         1475                1480                1485
Cys Leu Phe Asp Asn Phe Glu Cys Gln Gly Asn Ser Lys Thr Cys Lys 
     1490                1495                1500
Tyr Asp Lys Tyr Cys Ala Asp His Phe Lys Asp Asn His Cys Asp Gln 
 1505                1510                1515                1520
Gly Cys Asn Ser Glu Glu Cys Gly Trp Asp Gly Leu Asp Cys Ala Ala 
                 1525                1530                1535
Asp Gln Pro Glu Asn Leu Ala Glu Gly Thr Leu Val Ile Val Val Leu 
             1540                1545                1550
Met Pro Pro Glu Gln Leu Leu Gln Asp Ala Arg Ser Phe Leu Arg Ala 
         1555                1560                1565
Leu Gly Thr Leu Leu His Thr Asn Leu Arg Ile Lys Arg Asp Ser Gln 
     1570                1575                1580
Gly Glu Leu Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met 
 1585                1590                1595                1600
Lys Lys Gln Arg Met Thr Arg Arg Ser Leu Pro Gly Glu Gln Glu Gln 
                 1605                1610                1615
Glu Val Ala Gly Ser Lys Val Phe Leu Glu Ile Asp Asn Arg Gln Cys 
             1620                1625                1630
Val Gln Asp Ser Asp His Cys Phe Lys Asn Thr Asp Ala Ala Ala Ala 
         1635                1640                1645
Leu Leu Ala Ser His Ala Ile Gln Gly Thr Leu Ser Tyr Pro Leu Val 
     1650                1655                1660
Ser Val Val Ser Glu Ser Leu Thr Pro Glu Arg Thr Gln Leu Leu Tyr 
 1665                1670                1675                1680
Leu Leu Ala Val Ala Val Val Ile Ile Leu Phe Ile Ile Leu Leu Gly 
                 1685                1690                1695
Val Ile Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro 
             1700                1705                1710
Glu Gly Phe Thr Leu Arg Arg Asp Ala Ser Asn His Lys Arg Arg Glu 
         1715                1720                1725
Pro Val Gly Gln Asp Ala Val Gly Leu Lys Asn Leu Ser Val Gln Val 
     1730                1735                1740
Ser Glu Ala Asn Leu Ile Gly Thr Gly Thr Ser Glu His Trp Val Asp 
 1745                1750                1755                1760
Asp Glu Gly Pro Gln Pro Lys Lys Val Lys Ala Glu Asp Glu Ala Leu 
                 1765                1770                1775
Leu Ser Glu Glu Asp Asp Pro Ile Asp Arg Arg Pro Trp Thr Gln Gln 
             1780                1785                1790
His Leu Glu Ala Ala Asp Ile Arg Arg Thr Pro Ser Leu Ala Leu Thr 
         1795                1800                1805
Pro Pro Gln Ala Glu Gln Glu Val Asp Val Leu Asp Val Asn Val Arg 
     1810                1815                1820
Gly Pro Asp Gly Cys Thr Pro Leu Met Leu Ala Ser Leu Arg Gly Gly 
 1825                1830                1835                1840
Ser Ser Asp Leu Ser Asp Glu Asp Glu Asp Ala Glu Asp Ser Ser Ala 
                 1845                1850                1855
Asn Ile Ile Thr Asp Leu Val Tyr Gln Gly Ala Ser Leu Gln Ala Gln 
             1860                1865                1870
Thr Asp Arg Thr Gly Glu Met Ala Leu His Leu Ala Ala Arg Tyr Ser 
         1875                1880                1885
Arg Ala Asp Ala Ala Lys Arg Leu Leu Asp Ala Gly Ala Asp Ala Asn 
     1890                1895                1900
Ala Gln Asp Asn Met Gly Arg Cys Pro Leu His Ala Ala Val Ala Ala 
 1905                1910                1915                1920
Asp Ala Gln Gly Val Phe Gln Ile Leu Ile Arg Asn Arg Val Thr Asp 
                 1925                1930                1935
Leu Asp Ala Arg Met Asn Asp Gly Thr Thr Pro Leu Ile Leu Ala Ala 
             1940                1945                1950
Arg Leu Ala Val Glu Gly Met Val Ala Glu Leu Ile Asn Cys Gln Ala 
         1955                1960                1965
Asp Val Asn Ala Val Asp Asp His Gly Lys Ser Ala Leu His Trp Ala 
     1970                1975                1980
Ala Ala Val Asn Asn Val Glu Ala Thr Leu Leu Leu Leu Lys Asn Gly 
 1985                1990                1995                2000
Ala Asn Arg Asp Met Gln Asp Asn Lys Glu Glu Thr Pro Leu Phe Leu 
                 2005                2010                2015
Ala Ala Arg Glu Gly Ser Tyr Glu Ala Ala Lys Ile Leu Leu Asp His 
             2020                2025                2030
Phe Ala Asn Arg Asp Ile Thr Asp His Met Asp Arg Leu Pro Arg Asp 
         2035                2040                2045
Val Ala Arg Asp Arg Met His His Asp Ile Val Arg Leu Leu Asp Glu 
     2050                2055                2060
Tyr Asn Val Thr Pro Ser Pro Pro Gly Thr Val Leu Thr Ser Ala Leu 
 2065                2070                2075                2080
Ser Pro Val Ile Cys Gly Pro Asn Arg Ser Phe Leu Ser Leu Lys His 
                 2085                2090                2095
Thr Pro Met Gly Lys Lys Ser Arg Arg Pro Ser Ala Lys Ser Thr Met 
             2100                2105                2110
Pro Thr Ser Leu Pro Asn Leu Ala Lys Glu Ala Lys Asp Ala Lys Gly 
         2115                2120                2125
Ser Arg Arg Lys Lys Ser Leu Ser Glu Lys Val Gln Leu Ser Glu Ser 
     2130                2135                2140
Ser Val Thr Leu Ser Pro Val Asp Ser Leu Glu Ser Pro His Thr Tyr 
 2145                2150                2155                2160
Val Ser Asp Thr Thr Ser Ser Pro Met Ile Thr Ser Pro Gly Ile Leu 
                 2165                2170                2175
Gln Ala Ser Pro Asn Pro Met Leu Ala Thr Ala Ala Pro Pro Ala Pro 
             2180                2185                2190
Val His Ala Gln His Ala Leu Ser Phe Ser Asn Leu His Glu Met Gln 
         2195                2200                2205
Pro Leu Ala His Gly Ala Ser Thr Val Leu Pro Ser Val Ser Gln Leu 
     2210                2215                2220
Leu Ser His His His Ile Val Ser Pro Gly Ser Gly Ser Ala Gly Ser 
 2225                2230                2235                2240
Leu Ser Arg Leu His Pro Val Pro Val Pro Ala Asp Trp Met Asn Arg 
                 2245                2250                2255
Met Glu Val Asn Glu Thr Gln Tyr Asn Glu Met Phe Gly Met Val Leu 
             2260                2265                2270
Ala Pro Ala Glu Gly Thr His Pro Gly Ile Ala Pro Gln Ser Arg Pro 
         2275                2280                2285
Pro Glu Gly Lys His Ile Thr Thr Pro Arg Glu Pro Leu Pro Pro Ile 
     2290                2295                2300
Val Thr Phe Gln Leu Ile Pro Lys Gly Ser Ile Ala Gln Pro Ala Gly 
 2305                2310                2315                2320
Ala Pro Gln Pro Gln Ser Thr Cys Pro Pro Ala Val Ala Gly Pro Leu 
                 2325                2330                2335
Pro Thr Met Tyr Gln Ile Pro Glu Met Ala Arg Leu Pro Ser Val Ala 
             2340                2345                2350
Phe Pro Thr Ala Met Met Pro Gln Gln Asp Gly Gln Val Ala Gln Thr 
         2355                2360                2365
Ile Leu Pro Ala Tyr His Pro Phe Pro Ala Ser Val Gly Lys Tyr Pro 
     2370                2375                2380
Thr Pro Pro Ser Gln His Ser Tyr Ala Ser Ser Asn Ala Ala Glu Arg 
 2385                2390                2395                2400
Thr Pro Ser His Ser Gly His Leu Gln Gly Glu His Pro Tyr Leu Thr 
                 2405                2410                2415
Pro Ser Pro Glu Ser Pro Asp Gln Trp Ser Ser Ser Ser Pro His Ser 
             2420                2425                2430
Ala Ser Asp Trp Ser Asp Val Thr Thr Ser Pro Thr Pro Gly Gly Ala 
         2435                2440                2445
Gly Gly Gly Gln Arg Gly Pro Gly Thr His Met Ser Glu Pro Pro His 
     2450                2455                2460
Asn Asn Met Gln Val Tyr Ala 
 2465                2470



<210> 9648
<211> 8221
<212> DNA
<213> Rattus norvegicus
<308> X57405
<400> 9648

ggcgggtca  ggagcgcag  ggcgtgggg  gcagggccg  gtgcagcgc  gtgaaggaa  60
gagcctggg  tgccctgta  tgccgggga  accctgaga  cccagcccg  ccacccgcc  120
ggaaagagg  cagcagcgg  tggaacgcc  gcgggaccg  ccgtggtgc  cgtgaacgt  180
cgatcccgg  cggccaccg  aagaggccg  cgcccggca  cgggcagct  gcgagcagg  240
atgccgcgg  tcctggcgc  cttgctctg  ctaacgctg  tgcccgcgc  cgccgcaag  300
ggcttgaga  gctcccagc  aagtgggac  tgcctgaat  gagggaggt  cgaagtggc  360
aacggcact  aagcctgtg  ctgcagcgg  gcgttcgtg  gccagcgat  ccaggaccc  420
agcccttgc  tcagcacac  atgtaagaa  gctggaacg  gctatgttg  ggaccatgg  480
ggcatcgtg  actatgcct  cagttgccc  ctgggtttc  ctgggcccc  ctgcctgac  540
cctctggcc  atgcctgcc  ggccaaccc  tgccgcaac  gggggacct  tgacctgct  600
actctcaca  aatacaagt  ccggtgccc  ccagggtgg  caggaaagt  atgtcagca  660
gccgacccc  gtgcctcca  cccctgtgc  aatggtggc  agtgcctgc  ctttgagtc  720
tcatacatc  gtggctgcc  gcccggctt  catggcccc  cctgcagac  agatgttaa  780
gagtgcagc  agaaccctg  gttgtgccg  catgggggc  cgtgccaca  tgagattgg  840
tcctatcgc  gtgcctgcc  tgccaccca  actggtccc  actgcgagc  gccctacgt  900
ccctgcagc  cctcaccct  ccagaacgg  ggcacctgc  gccctacgg  ggacaccac  960
cacgagtgt  cctgcctgc  aggctttgc  ggacagaac  gtgaagaaa  tgtggatga  1020
tgcccagga  acaactgca  gaacggggg  gcctgtgtg  acggtgtga  tacctacaa  1080
tgccgctgc  caccggagt  gacaggtca  tactgcaca  aggatgtgg  cgagtgtca  1140
ctcatgccc  acgcctgcc  gaatgcggg  acctgccac  actcccacg  tggctacaa  1200
tgcgtgtgt  tcaatggct  gactggtga  gactgcagt  acaacattg  tgactgtgc  1260
agtgccgcc  gttttcagg  tgccacctg  catgaccgt  tggcttcct  ctactgcga  1320
tgtccacat  ggcgcacag  cctgctgtg  cacctgaac  atgcgtgta  cagcaaccc  1380
tgcaacgag  gctccaact  cgacaccaa  cctgtcaac  gcaaggcca  ctgcacttg  1440
cctcggggg  acacggggc  agcctgcag  caggacgtg  atgagtgcg  tctaggtgc  1500
aacccgtgt  agcacgcgg  caagtgcct  aacacactg  gctctttcg  gtgtcagtg  1560
ctacagggc  acactgggc  ccgctgtga  attgatgtc  acgagtgca  ctccaaccc  1620
tgtcagaat  atgccacgt  cctggacca  attggggag  ttcagtgta  atgtatgcc  1680
ggttatgag  gtgtatact  tgagatcaa  acggacgag  gtgccagca  cccctgtct  1740
cacaatggc  gctgcgtgg  caagatcaa  gagttcctg  gtcagtgtc  caaaggctt  1800
agcgggcac  tgtgccagt  tgacgtgga  gagtgcgcc  gcacaccat  caagaacgg  1860
gccaagtgc  tggatgggc  caacaccta  acctgcgtg  gcacagaag  ttacacggg  1920
acccactgc  aggtggaca  tgacgagtg  gaccctgac  cctgtcaca  tggtttgtg  1980
aaggatggt  tggccacct  tacctgcct  tgccagcca  gctacacag  ccatcactg  2040
gagaccaac  ttaatgagt  tcacagcca  ccgtgccgc  atggcggca  ctgccagga  2100
cgtgacaac  actacctct  cttatgcct  aaggggacc  caggaccca  ctgtgagat  2160
aatctggat  actgtgcga  caacccctg  gactctggc  cgtgtctgg  caagatcga  2220
ggctacgag  gtgcgtgcg  gccaggcta  acagggagc  tgtgtaatg  caacattga  2280
gaatgtgcg  gcagcccct  ccacaacgg  ggcacctgt  aggatggca  cgccggctt  2340
acttgccgc  gccccgagg  ctaccacga  cctacgtgc  tgtctgagg  caacgagtg  2400
aacagtaac  cctgcatcc  tggagcttg  cgggatggc  tcaatggat  caaatgtga  2460
tgtgcccct  ggtggagtg  gacaaactg  gacatcaac  acaatgagt  tgagtccaa  2520
ccttgtgtc  acggtggca  ctgcaaaga  atgaccagt  gctacgtat  cacctgccg  2580
gaaggcttc  gtggcccta  ctgccagac  aacattaac  aatgtgctt  caacccctg  2640
ctgaaccag  gcacctgca  tgatgatgt  gctgggtac  aatgcaact  ccctctgcc  2700
tatacagga  ccacatgtg  ggtggtgtt  gccccatgt  ccaccagcc  ctgcaaaaa  2760
agtggggta  gcaaggagt  tgaggacta  gagagcttt  cctgtgtct  tcccacagg  2820
tggcaaggt  aaacctgcg  gatcgacat  aatgagtgt  tgaaaagcc  gtgtcgcca  2880
ggtgcctct  gccagaaca  caatggcag  taccgctgc  tctgccagg  tggctacac  2940
ggtcgcaac  gcgagagtg  catcgatga  tgccgaccc  acccatgtc  caacggggg  3000
tcctgcact  acggggtca  cgcggcctt  tgcgactgc  tgcccggct  ccagggtgc  3060
ttctgtgag  aggacatca  cgaatgcgc  acgaatcca  gccaaaatg  cgccaactg  3120
actgactgc  tggacagct  cacgtgcac  tgccccacc  ggttcaatg  catccattg  3180
gagaacaac  cacctgact  taccgagag  tcctgtttc  atggtggca  ctgtgtgga  3240
ggtatcaac  ccttcacct  tctgtgccc  cctggcttc  cgggcagct  ctgccagta  3300
gacgtcaat  agtgtgact  acggccctg  ctgcatggt  gcacctgcc  agacagcta  3360
ggtacctat  agtgtacct  cccacaggg  tacactggt  tcaactgcc  gaaccttgt  3420
cgctggtgt  actcagctc  ctgcaagaa  ggcggcaag  gctggcaga  caacacaca  3480
taccactgc  agtgccgca  cggctggac  ggcttcaac  gcgacgtgc  cagtgtgtc  3540
tgcgaggtg  ctgcacaga  gcgaggcat  gatgtcact  tcctatgcc  gcacggagg  3600
ctctgtgtg  atgaggaag  caagcatta  tgccactgc  aggcaggat  cacgggcag  3660
tactgtgag  acgaggtgg  cgagtgctc  cctaatccc  gccagaacg  agccacctg  3720
actgactat  tcggtggct  ttcctgcaa  tgtgtggct  ggtaccatg  ctctaactg  3780
tctgaggag  tcaacgagt  cctatccca  ccctgccag  atgggggta  ctgcattga  3840
ctgaccaac  cctacaagt  ctcctgccc  aggggcaca  agggtgtac  ctgtgagat  3900
aacgtcgat  actgccatc  tcccctaga  cctgcttcc  gaagcccca  atgcttcaa  3960
aatggcacc  gcgtggacc  ggtgggtgg  tatacctgc  cctgcccgc  aggcttcgt  4020
ggggagcgg  gcgagggcg  tgtcaatga  tgtctctcc  acccctgtg  cccacgtgg  4080
acccagaac  gcgtgcagc  tgttaatga  ttccactgc  agtgccggg  tggccacac  4140
ggacgccgc  gtgagtcgg  cattaatgg  tgcaggggc  aaccatgca  gaatggagg  4200
gtctgtgct  tggcctcca  caccgcccg  ggattcatc  gtaggtgcc  tgcccgctt  4260
gagggtgcc  cttgtgaaa  tgacgcccg  acttgtggc  gtttgcgct  cctcaacgg  4320
ggtacgtgc  tctcaggcc  acgcagtcc  acctgccta  gcctgggct  cttcactgg  4380
cctgaatgc  agttcccag  cagcagccc  tgtgtgggt  gcaacccct  ctacaatca  4440
ggcacctgt  agcccacat  cgagagccc  ttctaccgc  gtctatgcc  tgccaaatt  4500
aacgggctg  tgtgccaca  cctggacta  agcttcaca  gtgcggccg  gcgcgacat  4560
cccccgcca  agattgagg  ggcctgcga  ctgcctgag  gccaggagg  tgcaggcaa  4620
aaggtctgc  accttcagt  taataatca  gcgtgtggc  gggacggcg  cgactgctc  4680
ctcaacttc  atgaccctt  gaagaactg  actcagtcc  tgcagtgct  gaagtattt  4740
agtgacggc  actgtgaca  ccagtgcaa  tcagctggc  gcctttttg  tggcttcga  4800
tgccagctc  ccgagggac  gtgcaaccc  ctgtatgac  agtactgca  ggaccactt  4860
agtgatggc  actgcgacc  gggctgcaa  agtgccgag  gtgagtggg  tggactgga  4920
tgtgcagag  atgtccccg  gcgactggc  gccggcaca  tggtgctgg  ggtgctgct  4980
ccgcccgat  agctacgca  caactcctt  cacttcctg  gggacgtca  ccacgtgct  5040
cacaccaac  tggtcttca  gcgtgacgc  cagggccag  agatgatct  cccctacta  5100
ggccgcgag  aagagctac  caagcaccc  atcaagcgt  ctgcagtgg  ctgggccac  5160
acgtcactg  ttcctggca  caatggtgg  cgccagcgc  gggagctgg  ccccatgga  5220
atccatggc  ccatcgtct  cctggagat  gacaaccgg  agtgtgtac  gtcatcctc  5280
caatgcttc  agagcgcca  cgatgtggc  gccttccta  gtgctcttg  ctccctcgg  5340
agcctcaat  tcccctaca  gatcgaagc  gtaaagagt  agacggtgg  gcctccgct  5400
ccctcacag  tgcacctca  gtacgtggc  gcagctgcc  tcgtgctcc  gttctttgt  5460
ggctgtggg  tgctgctgt  ccgcaagcg  aggcggcag  atggccagc  ctggttccc  5520
gagggtttc  aagtgtcag  ggccagcaa  aagaagcgg  gagaacccc  cggcgagga  5580
tcagtcggc  tcaagcccc  gaagaacgc  tcagatggt  ccctgatgg  cgacaatca  5640
aacgagtgg  gggacgaag  cctggagac  aagaagttc  ggtttgagg  accagtggt  5700
ctccctgac  tggatgatc  gactgacca  cggcagtgg  cccagcagc  cctggatgc  5760
gctgaccta  gtgtgtctg  catggcccc  acgccgcct  agggggagg  agatgctga  5820
tgcatggac  tcaatgttc  aggaccaga  ggcttcact  ccctaatga  tgcctcctg  5880
agcggaggg  gcctggaga  aggcaacag  gaggaagaa  aagatgcac  tgctgtcat  5940
tccgacttc  tctatcagg  tgccagctt  cacaaccag  cggaccgca  aggggagac  6000
gccctgcac  tggctgccc  atactctcg  tcagatgct  ccaagcgct  gctggaggc  6060
agcgcagat  ccaacatcc  agacaacat  gggcgtacc  cattacatg  cgctgtttc  6120
gcagacgct  agggtgtct  ccagatcct  ctccggaac  gagccacag  tctggatgc  6180
cgaatgcat  atggcacaa  ccctctgat  ctggcggca  gcctggccg  ggaaggcat  6240
ctagaggac  tcatcaact  tcacgctga  gtcaatgct  tggatgacc  aggcaagtc  6300
gctctgcac  gggcagccg  tgtgaacaa  gtggacgct  ctgttgtgc  cctgaagaa  6360
ggagccaac  aagacatgc  gaacaacaa  gaggagact  ccctgttcc  ggccgcccg  6420
gagggcagc  atgagactg  caaagtgtt  ctggaccac  ttgccaacc  ggacatcac  6480
gatcacatg  accgattgc  acgggacat  gcacaggag  gcatgcacc  cgatatcgt  6540
cggcttttg  atgaataca  cctggtgcg  agcccacag  tgcatggca  tgccttggg  6600
ggcacaccc  ctctgtctc  cacactctg  tcgcccaac  gctacctgg  caacctcaa  6660
tctgccaca  agggcaaga  ggcccgaaa  cccagcacc  aagggctgg  ttgcagtag  6720
aaggaagct  aggacctca  ggcccggag  aagaagtcc  aggatggca  gggctgcct  6780
ttggacagc  caagcatgc  gtcacccgt  gactccctc  agtcacccc  tggctactt  6840
tcagatgtg  cctcaccac  cctccttcc  tccccgttc  agcagtctc  atccatgcc  6900
ctcagccac  tgccaggta  gcctgacac  cacctgggc  tcagccact  gaatgtggc  6960
gccaagccc  agatggcag  tctggccgg  ggcagccgg  tggcctttg  gccaccccc  7020
ccacgcctc  cccacctgc  tgtagcctc  agtgccagc  cagtgctga  taccaatgg  7080
acaggggct  tgaatttca  cgtgggtgc  ccggcaagc  tgaatggcc  gtgtgagtg  7140
cttccccgg  tccagaatg  catggtgcc  agccagtac  acccgctaa  gccaggtgt  7200
actccgggc  cactaagca  acaggcagc  ggcctccag  atggcatga  gggcccgat  7260
cacagcagc  tctccacca  taccttgtc  ccgattatc  accagggcc  gcccaacac  7320
aggctggcc  cacagcccc  cctggtgca  acccagcag  tgcagccac  gaacttaca  7380
atccagcct  agaacctgc  gccaccatc  cagccacac  tcagtgtga  ctcagcagc  7440
aatgggcac  tgggtcgga  cttcctgag  ggggagccc  gccaggcag  cgtacagcc  7500
ctgggcccc  gcagtctgc  tgtgcacac  attctgccc  aggaaagcc  ggctctgcc  7560
acatcactg  catcctcca  ggtcccacc  atgaccact  cccagttcc  gacccctcc  7620
tctcagcac  gctactcat  ctcacctgt  gacaacacc  ccagccacc  gctgcaggt  7680
ccagagcac  ccttcctca  cccatcccc  gagtcccct  accagtggt  cagctcctc  7740
cggcattcc  acatctctg  ttggtccga  ggcatctct  gcccgccca  gagcatgcc  7800
tcccagatc  cccacattc  agaggcatt  aagtaaaca  agatgtggg  tgaaggacc  7860
cagcttccg  tcccaagct  tgttgggag  cctttccag  gctccagga  gctggggcg  7920
ccaaaggag  cttttaaaa  aaaatgttt  tatacaaaa  aagaggaca  gaatttcca  7980
ttttttttt  gtatttatt  atgtacttt  attttccac  gaaacactg  ctttttatt  8040
atatgtatt  ttttctatg  cactagggg  aaacatctg  tccaagaaa  taaactagt  8100
ctgagagcc  cgattttcc  ggtcagggt  aagttccct  tgtgtttgt  aaatacgaa  8160
aaggattca  gatttgtaa  tgccgttta  ttattgatt  cttctttcc  aaatcgtcg  8220
g  8221



<210> 9649
<211> 2531
<212> PRT
<213> Rattus norvegicus
<308> CAA40667
<400> 9649

Met Pro Arg Leu Leu Ala Pro Leu Leu Cys Leu Thr Leu Leu Pro Ala 
  1               5                  10                  15
Leu Ala Ala Arg Gly Leu Arg Cys Ser Gln Pro Ser Gly Thr Cys Leu 
             20                  25                  30
Asn Gly Gly Arg Cys Glu Val Ala Asn Gly Thr Glu Ala Cys Val Cys 
         35                  40                  45
Ser Gly Ala Phe Val Gly Gln Arg Cys Gln Asp Pro Ser Pro Cys Leu 
     50                  55                  60
Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys Tyr Val Val Asp His Gly 
 65                  70                  75                  80
Gly Ile Val Asp Tyr Ala Cys Ser Cys Pro Leu Gly Phe Ser Gly Pro 
                 85                  90                  95
Leu Cys Leu Thr Pro Leu Ala Asn Ala Cys Leu Ala Asn Pro Cys Arg 
             100                105                110
Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
         115                120                125
Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
     130                135                140
Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ser 
 145                150                155                160
Ser Tyr Ile Cys Gly Cys Pro Pro Gly Phe His Gly Pro Thr Cys Arg 
                 165                170                175
Gln Asp Val Asn Glu Cys Ser Gln Asn Pro Gly Leu Cys Arg His Gly 
             180                185                190
Gly Thr Cys His Asn Glu Ile Gly Ser Tyr Arg Cys Ala Cys Arg Ala 
         195                200                205
Thr His Thr Gly Pro His Cys Glu Leu Pro Tyr Val Pro Cys Ser Pro 
     210                215                220
Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Thr Thr 
 225                230                235                240
His Glu Cys Ala Cys Leu Pro Gly Phe Ala Gly Gln Asn Cys Glu Glu 
                 245                250                255
Asn Val Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
             260                265                270
Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
         275                280                285
Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
     290                295                300
Ala Cys Gln Asn Ala Gly Thr Cys His Asn Ser His Gly Gly Tyr Asn 
 305                310                315                320
Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Asp Asn Ile 
                 325                330                335
Asp Asp Cys Ala Ser Ala Ala Cys Phe Gln Gly Ala Thr Cys His Asp 
             340                345                350
Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
         355                360                365
Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
     370                375                380
Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
 385                390                395                400
Pro Arg Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                 405                410                415
Ala Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Leu Asn Thr 
             420                425                430
Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
         435                440                445
Cys Glu Ile Asp Val Asn Glu Cys Ile Ser Asn Pro Cys Gln Asn Asp 
     450                455                460
Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
 465                470                475                480
Gly Tyr Glu Gly Val Tyr Cys Glu Ile Asn Thr Asp Glu Cys Ala Ser 
                 485                490                495
Ser Pro Cys Leu His Asn Gly Arg Cys Val Asp Lys Ile Asn Glu Phe 
             500                505                510
Leu Cys Gln Cys Pro Lys Gly Phe Ser Gly His Leu Cys Gln Tyr Asp 
         515                520                525
Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
     530                535                540
Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
 545                550                555                560
Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                 565                570                575
Ile Gly Leu Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Gln 
             580                585                590
Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys His 
         595                600                605
Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Tyr 
     610                615                620
Tyr Leu Cys Leu Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
 625                630                635                640
Asn Leu Asp Asp Cys Ala Ser Asn Pro Cys Asp Ser Gly Thr Cys Leu 
                 645                650                655
Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
             660                665                670
Ser Met Cys Asn Val Asn Ile Asp Glu Cys Ala Gly Ser Pro Cys His 
         675                680                685
Asn Gly Gly Thr Cys Glu Asp Gly Ile Ala Gly Phe Thr Cys Arg Cys 
     690                695                700
Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
 705                710                715                720
Asn Ser Asn Pro Cys Ile His Gly Ala Cys Arg Asp Gly Leu Asn Gly 
                 725                730                735
Tyr Lys Cys Asp Cys Ala Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
             740                745                750
Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
         755                760                765
Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
     770                775                780
Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
 785                790                795                800
Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                 805                810                815
Cys Pro Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
             820                825                830
Cys Ala Thr Ser Pro Cys Lys Asn Ser Gly Val Cys Lys Glu Ser Glu 
         835                840                845
Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
     850                855                860
Thr Cys Glu Ile Asp Ile Asn Glu Cys Val Lys Ser Pro Cys Arg His 
 865                870                875                880
Gly Ala Ser Cys Gln Asn Thr Asn Gly Ser Tyr Arg Cys Leu Cys Gln 
                 885                890                895
Ala Gly Tyr Thr Gly Arg Asn Cys Glu Ser Asp Ile Asp Asp Cys Arg 
             900                905                910
Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Val Asn Ala 
         915                920                925
Ala Phe Cys Asp Cys Leu Pro Gly Phe Gln Gly Ala Phe Cys Glu Glu 
     930                935                940
Asp Ile Asn Glu Cys Ala Thr Asn Pro Cys Gln Asn Gly Ala Asn Cys 
 945                950                955                960
Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Thr Gly Phe Asn 
                 965                970                975
Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
             980                985                990
Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser Phe Thr Cys Leu 
         995                1000                1005
Cys Pro Pro Gly Phe Thr Gly Ser Tyr Cys Gln Tyr Asp Val Asn Glu 
     1010                1015                1020
Cys Asp Ser Arg Pro Cys Leu His Gly Gly Thr Cys Gln Asp Ser Tyr 
 1025                1030                1035                1040
Gly Thr Tyr Lys Cys Thr Cys Pro Gln Gly Tyr Thr Gly Leu Asn Cys 
                 1045                1050                1055
Gln Asn Leu Val Arg Trp Cys Asp Ser Ala Pro Cys Lys Asn Gly Gly 
             1060                1065                1070
Lys Cys Trp Gln Thr Asn Thr Gln Tyr His Cys Glu Cys Arg Ser Gly 
         1075                1080                1085
Trp Thr Gly Phe Asn Cys Asp Val Leu Ser Val Ser Cys Glu Val Ala 
     1090                1095                1100
Ala Gln Lys Arg Gly Ile Asp Val Thr Leu Leu Cys Gln His Gly Gly 
 1105                1110                1115                1120
Leu Cys Val Asp Glu Glu Asp Lys His Tyr Cys His Cys Gln Ala Gly 
                 1125                1130                1135
Tyr Thr Gly Ser Tyr Cys Glu Asp Glu Val Asp Glu Cys Ser Pro Asn 
             1140                1145                1150
Pro Cys Gln Asn Gly Ala Thr Cys Thr Asp Tyr Leu Gly Gly Phe Ser 
         1155                1160                1165
Cys Lys Cys Val Ala Gly Tyr His Gly Ser Asn Cys Ser Glu Glu Ile 
     1170                1175                1180
Asn Glu Cys Leu Ser Gln Pro Cys Gln Asn Gly Gly Thr Cys Ile Asp 
 1185                1190                1195                1200
Leu Thr Asn Thr Tyr Lys Cys Ser Cys Pro Arg Gly Thr Gln Gly Val 
                 1205                1210                1215
His Cys Glu Ile Asn Val Asp Asp Cys His Pro Pro Leu Asp Pro Ala 
             1220                1225                1230
Ser Arg Ser Pro Lys Cys Phe Asn Asn Gly Thr Cys Val Asp Gln Val 
         1235                1240                1245
Gly Gly Tyr Thr Cys Thr Cys Pro Pro Gly Phe Val Gly Glu Arg Cys 
     1250                1255                1260
Glu Gly Asp Val Asn Glu Cys Leu Ser Asn Pro Cys Asp Pro Arg Gly 
 1265                1270                1275                1280
Thr Gln Asn Cys Val Gln Arg Val Asn Asp Phe His Cys Glu Cys Arg 
                 1285                1290                1295
Ala Gly His Thr Gly Arg Arg Cys Glu Ser Val Ile Asn Gly Cys Arg 
             1300                1305                1310
Gly Lys Pro Cys Arg Asn Gly Gly Val Cys Ala Val Ala Ser Asn Thr 
         1315                1320                1325
Ala Arg Gly Phe Ile Cys Arg Cys Pro Ala Arg Phe Glu Gly Ala Thr 
     1330                1335                1340
Cys Glu Asn Asp Ala Arg Thr Cys Gly Ser Leu Arg Cys Leu Asn Gly 
 1345                1350                1355                1360
Gly Thr Cys Ile Ser Gly Pro Arg Ser Pro Thr Cys Leu Cys Leu Gly 
                 1365                1370                1375
Ser Phe Thr Gly Pro Glu Cys Gln Phe Pro Ala Ser Ser Pro Cys Val 
             1380                1385                1390
Gly Ser Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro Thr Ser Glu 
         1395                1400                1405
Ser Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn Gly Leu Leu 
     1410                1415                1420
Cys His Ile Leu Asp Tyr Ser Phe Thr Gly Ala Ala Gly Arg Asp Ile 
 1425                1430                1435                1440
Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Glu 
                 1445                1450                1455
Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys 
             1460                1465                1470
Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys 
         1475                1480                1485
Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His 
     1490                1495                1500
Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp 
 1505                1510                1515                1520
Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys 
                 1525                1530                1535
Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala 
             1540                1545                1550
Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg 
         1555                1560                1565
Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln 
     1570                1575                1580
Leu Arg Asn Asn Ser Phe His Phe Leu Arg Asp Val Ser His Val Leu 
 1585                1590                1595                1600
His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile 
                 1605                1610                1615
Phe Pro Tyr Tyr Gly Arg Glu Glu Glu Leu Arg Lys His Pro Ile Lys 
             1620                1625                1630
Arg Ser Ala Val Gly Trp Ala Thr Thr Ser Leu Leu Pro Gly Thr Asn 
         1635                1640                1645
Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile His Gly Ser 
     1650                1655                1660
Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser 
 1665                1670                1675                1680
Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu 
                 1685                1690                1695
Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys 
             1700                1705                1710
Ser Glu Thr Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr 
         1715                1720                1725
Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val 
     1730                1735                1740
Leu Leu Ser Arg Lys Arg Arg Arg Gln His Gly Gln Leu Trp Phe Pro 
 1745                1750                1755                1760
Glu Gly Phe Lys Val Ser Glu Ala Ser Lys Lys Lys Arg Arg Glu Pro 
                 1765                1770                1775
Leu Gly Glu Asp Ser Val Gly Leu Lys Pro Leu Lys Asn Ala Ser Asp 
             1780                1785                1790
Gly Ala Leu Met Asp Asp Asn Gln Asn Glu Trp Gly Asp Glu Asp Leu 
         1795                1800                1805
Glu Thr Lys Lys Phe Arg Phe Glu Glu Pro Val Val Leu Pro Asp Leu 
     1810                1815                1820
Asp Asp Gln Thr Asp His Arg Gln Trp Thr Gln Gln His Leu Asp Ala 
 1825                1830                1835                1840
Ala Asp Leu Arg Val Ser Ala Met Ala Pro Thr Pro Pro Gln Gly Glu 
                 1845                1850                1855
Val Asp Ala Asp Cys Met Asp Val Asn Val Arg Gly Pro Asp Gly Phe 
             1860                1865                1870
Thr Pro Leu Met Ile Ala Ser Cys Ser Gly Gly Gly Leu Glu Thr Gly 
         1875                1880                1885
Asn Ser Glu Glu Glu Glu Asp Ala Pro Ala Val Ile Ser Asp Phe Ile 
     1890                1895                1900
Tyr Gln Gly Ala Ser Leu His Asn Gln Thr Asp Arg Thr Gly Glu Thr 
 1905                1910                1915                1920
Ala Leu His Leu Ala Ala Arg Tyr Ser Arg Ser Asp Ala Ala Lys Arg 
                 1925                1930                1935
Leu Leu Glu Ala Ser Ala Asp Ala Asn Ile Gln Asp Asn Met Gly Arg 
             1940                1945                1950
Thr Pro Leu His Ala Ala Val Ser Ala Asp Ala Gln Gly Val Phe Gln 
         1955                1960                1965
Ile Leu Leu Arg Asn Arg Ala Thr Asp Leu Asp Ala Arg Met His Asp 
     1970                1975                1980
Gly Thr Thr Pro Leu Ile Leu Ala Ala Arg Leu Ala Val Glu Gly Met 
 1985                1990                1995                2000
Leu Glu Asp Leu Ile Asn Ser His Ala Asp Val Asn Ala Val Asp Asp 
                 2005                2010                2015
Leu Gly Lys Ser Ala Leu His Trp Ala Ala Ala Val Asn Asn Val Asp 
             2020                2025                2030
Ala Ala Val Val Leu Leu Lys Asn Gly Ala Asn Lys Asp Met Gln Asn 
         2035                2040                2045
Asn Lys Glu Glu Thr Pro Leu Phe Leu Ala Ala Arg Glu Gly Ser Tyr 
     2050                2055                2060
Glu Thr Ala Lys Val Leu Leu Asp His Phe Ala Asn Arg Asp Ile Thr 
 2065                2070                2075                2080
Asp His Met Asp Arg Leu Pro Arg Asp Ile Ala Gln Glu Arg Met His 
                 2085                2090                2095
His Asp Ile Val Arg Leu Leu Asp Glu Tyr Asn Leu Val Arg Ser Pro 
             2100                2105                2110
Gln Leu His Gly Thr Ala Leu Gly Gly Thr Pro Thr Leu Ser Pro Thr 
         2115                2120                2125
Leu Cys Ser Pro Asn Gly Tyr Leu Gly Asn Leu Lys Ser Ala Thr Gln 
     2130                2135                2140
Gly Lys Lys Ala Arg Lys Pro Ser Thr Lys Gly Leu Ala Cys Ser Ser 
 2145                2150                2155                2160
Lys Glu Ala Lys Asp Leu Lys Ala Arg Arg Lys Lys Ser Gln Asp Gly 
                 2165                2170                2175
Lys Gly Cys Leu Leu Asp Ser Ser Ser Met Leu Ser Pro Val Asp Ser 
             2180                2185                2190
Leu Glu Ser Pro His Gly Tyr Leu Ser Asp Val Ala Ser Pro Pro Leu 
         2195                2200                2205
Leu Pro Ser Pro Phe Gln Gln Ser Pro Ser Met Pro Leu Ser His Leu 
     2210                2215                2220
Pro Gly Met Pro Asp Thr His Leu Gly Ile Ser His Leu Asn Val Ala 
 2225                2230                2235                2240
Ala Lys Pro Glu Met Ala Ala Leu Ala Gly Gly Ser Arg Leu Ala Phe 
                 2245                2250                2255
Glu Pro Pro Pro Pro Arg Leu Ser His Leu Pro Val Ala Ser Ser Ala 
             2260                2265                2270
Ser Thr Val Leu Ser Thr Asn Gly Thr Gly Ala Met Asn Phe Thr Val 
         2275                2280                2285
Gly Ala Pro Ala Ser Leu Asn Gly Gln Cys Glu Trp Leu Pro Arg Leu 
     2290                2295                2300
Gln Asn Gly Met Val Pro Ser Gln Tyr Asn Pro Leu Arg Pro Gly Val 
 2305                2310                2315                2320
Thr Pro Gly Thr Leu Ser Thr Gln Ala Ala Gly Leu Gln His Gly Met 
                 2325                2330                2335
Met Gly Pro Ile His Ser Ser Leu Ser Thr Asn Thr Leu Ser Pro Ile 
             2340                2345                2350
Ile Tyr Gln Gly Leu Pro Asn Thr Arg Leu Ala Thr Gln Pro His Leu 
         2355                2360                2365
Val Gln Thr Gln Gln Val Gln Pro Gln Asn Leu Gln Ile Gln Pro Gln 
     2370                2375                2380
Asn Leu Gln Pro Pro Ser Gln Pro His Leu Ser Val Ser Ser Ala Ala 
 2385                2390                2395                2400
Asn Gly His Leu Gly Arg Ser Phe Leu Ser Gly Glu Pro Ser Gln Ala 
                 2405                2410                2415
Asp Val Gln Pro Leu Gly Pro Ser Ser Leu Pro Val His Thr Ile Leu 
             2420                2425                2430
Pro Gln Glu Ser Gln Ala Leu Pro Thr Ser Leu Pro Ser Ser Met Val 
         2435                2440                2445
Pro Pro Met Thr Thr Thr Gln Phe Leu Thr Pro Pro Ser Gln His Ser 
     2450                2455                2460
Tyr Ser Ser Ser Pro Val Asp Asn Thr Pro Ser His Gln Leu Gln Val 
 2465                2470                2475                2480
Pro Glu His Pro Phe Leu Thr Pro Ser Pro Glu Ser Pro Asp Gln Trp 
                 2485                2490                2495
Ser Ser Ser Ser Arg His Ser Asn Ile Ser Asp Trp Ser Glu Gly Ile 
             2500                2505                2510
Ser Ser Pro Pro Thr Ser Met Pro Ser Gln Ile Thr His Ile Pro Glu 
         2515                2520                2525
Ala Phe Lys 
     2530



<210> 9650
<211> 11395
<212> DNA
<213> Homo sapiens
<308> XM_034671
<400> 9650

tttcagcca  acttcgggc  gcggctgag  cggcggccg  ggagcggcg  actcggggc  60
cggggagtc  aggcatttg  gcctgggct  cggagcgta  cgccagggc  tgagccttt  120
aagcaggag  aggggagga  agagtgggg  tcctctatc  ggaccccct  cccatgtgg  180
tctgcccag  cggcggcgg  ggcggcgga  gaggaggcg  ccgagaaga  gcccgccct  240
cgccccgct  tgctgtggg  gctgctggc  ctctggctg  gctgcgcgg  ccccgcgca  300
gcattgcag  gtcgagatg  ctatgaacc  tgtgtaaat  aaggaatgt  tgttaccta  360
cacaatggc  caggatact  caaatgtcc  gaaggcttc  tgggggaat  ttgtcaaca  420
cgagacccc  gtgagaaga  ccgctgcca  aatggtggg  cttgtgtgg  ccaggccat  480
ctggggaaa  ccacgtgcc  atgtgcctc  gggtttaca  gagaggact  ccagtactc  540
acatctcat  catgctttg  gtctcgacc  tgcctgaat  gcggcacat  ccatatgct  600
agccgggat  cctatgagt  cacctgtca  gtcgggttt  caggtaagg  gtgccaatg  660
acggatgcc  gcctgtctc  tccctgtgc  aatggaagt  cctgtacca  tgtggccaa  720
cagttctcc  gcaaatgcc  cacaggctt  acagggcag  aatgtgaga  tgatgtcaa  780
gagtgtgac  ttccaggac  ctgccagca  ggtggcacc  gcctcaacc  gcctggttc  840
taccagtgc  agtgccctc  gggcttcac  ggccagtac  gtgacagcc  gtatgtgcc  900
tgtgcaccc  caccttgtg  caatggagg  acctgtcgg  agactggtg  cttcacttt  960
gagtgcaac  gccttccag  ttttgaagg  agcacctgt  agaggaata  tgatgactg  1020
cctaaccac  ggtgtcaga  tggaggggt  tgtgtggat  gggtcaaca  ttacaactg  1080
cgctgtccc  cacaatgga  aggacagtt  tgcacagag  atgtggatg  atgcctgct  1140
cagcccaat  cctgtcaaa  tgggggcac  tgtgccaac  gcaatggag  ctatggctg  1200
gtatgtgtc  acggctgga  tggagatga  tgcagtgag  acattgatg  ttgtgcctt  1260
gcctcctgt  ctccaggct  cacctgcat  gaccgtgtg  cctccttct  ttgcatgtg  1320
ccagagggg  aggcaggtc  cctgtgtca  ctggatgat  catgcatca  caatccttg  1380
cacaagggg  cactgtgtg  caccaaccc  ctaaatggg  aatatattt  cacctgccc  1440
caaggctac  aaggggctg  ctgcacaga  gatgtggat  aatgtgcca  ggccaatag  1500
aatccttgt  agcatgcag  aaaatgtgt  aacacggat  gcgccttcc  ctgtgagtg  1560
ctgaagggt  atgcaggac  tcgttgtga  atggacatc  atgagtgcc  ttcagaccc  1620
tgccagaat  atgctacct  tctggataa  attggaggc  tcacatgtc  gtgcatgcc  1680
ggtttcaaa  gtgtgcatt  tgaattaga  ataaatgaa  gtcagagca  cccttgtgt  1740
aacaatggg  agtgtgtgg  taaagtcaa  cgtttccag  gcctgtgtc  tcctggttt  1800
actgggcca  tttgccaga  tgatattga  gactgttcc  gtactccgt  tctgaatgg  1860
gcaaagtgt  tcgatcacc  gaatggcta  gaatgccag  gtgccacag  tttcactgg  1920
gtgttgtgt  aggagaaca  tgacaactg  gaccccgat  cttgccacc  tggtcagtg  1980
caggatggt  ttgattcct  cacctgcat  tgcaatccc  ggtacatgg  cgccatctg  2040
agtgaccag  ttgatgaat  ttacagcag  ccttgcctg  acgatggtc  ctgcattga  2100
ctggtcaat  gctaccagt  caactgcca  ccaggcacg  caggggtta  ttgtgaaat  2160
aattttgat  actgtgcaa  taacccttg  atccatgga  tctgtatgg  tggcattaa  2220
cgctacagt  gtgtctgct  accaggatt  acagggcag  gatgtaaca  tgacattga  2280
gagtgtgcc  ccaatccct  tcgcaaggg  gcaacatgt  tcaacggtg  gaatggttt  2340
cgctgtata  gccccgagg  accccatca  cccagctgc  actcacagg  gaacgaatg  2400
ctgagcaat  cctgcatcc  tggaaactg  actggaggt  tcagtggat  taagtgtct  2460
tgtgatgca  gctgggttg  catcaactg  gaagtggac  aaaatgaat  cctttcgaa  2520
ccatgccag  atggaggaa  ttgtgacaa  ctggtgaat  gatacaggt  tacttgcaa  2580
aagggcttt  aaggctata  ctgccaggt  aatattgat  aatgtgcct  aaatccatg  2640
ctgaaccaa  gaacctgct  tgatgacat  agtggctac  cttgccact  tgtgctgcc  2700
tacacaggc  agaattgtc  gacagtatt  gctccctgt  ccccaaacc  ttgtgagaa  2760
gctgctgtt  gcaaagagt  accaaattt  gagagttat  cttgcttgt  tgctcctgg  2820
tggcaaggt  agcggtgta  cattgacat  gacgagtgt  tctccaagc  ctgcatgaa  2880
catggtctc  gccataaca  ccagggcag  tacatgtgt  aatgtccac  aggcttcag  2940
ggtatggac  gtgaggagg  cattgatga  tgccttgcc  atccttgcc  gaatggagg  3000
tcctgtatg  atggagtga  tactttctc  tgcctctgc  ttccgggtt  cactgggga  3060
aagtgccag  cagacatga  tgagtgtct  agtgaaccc  gtaagaatg  agggacctg  3120
tctgactac  tcaacagtt  cacttgcaa  tgccaggca  gatttgatg  agtccattg  3180
gagaacaac  tcaatgagt  cactgagag  tcctgtttc  atggtggca  atgtgttga  3240
gggattaac  ccttctctt  cttgtgccc  gtgggtttc  ctggatcct  ctgcctcca  3300
gagatcaat  aatgcagct  tcatccatg  ctgaatgag  gaacgtgtg  tgatggcct  3360
ggtacctac  gctgcagct  ccccctggg  tacactggg  aaaactgtc  gaccctggt  3420
aatctctgc  gtcggtctc  atgtaaaaa  aaaggtact  gcgttcaga  aaaagcaga  3480
tcccagtgc  tatgtccat  tggatgggc  ggtgcctat  gtgacgtgc  caatgtctc  3540
tgtgacata  cagcctcca  gagaggtgt  cttgttgaa  acttgtgcc  gcactcagg  3600
gtctgcatc  atgctggca  cacgcatta  tgtcagtgc  ccctgggct  tactgggag  3660
tactgtgag  agcaactcg  tgagtgtgc  tccaacccc  gccagcacg  ggcaacatg  3720
agtgacttc  ttggtggat  cagatgcga  tgtgtccca  gctatcagg  tgtcaactg  3780
gagtatgaa  tggatgagt  ccagaatca  ccctgccag  atggaggca  ctgtattga  3840
cttgtgaac  atttcaagt  ctcttgccc  ccaggcact  ggggcctac  ctgtgaaga  3900
aacattgat  actgtgccc  gggtcccca  tgccttaat  gtggtcagt  catggatag  3960
attggaggc  acagttgtc  ctgcttgcc  ggctttgct  gggagcgtt  tgagggaga  4020
atcaacgag  gcctctcca  cccctgcag  tctgagggc  gcctggact  tatacagct  4080
accaatgac  acctgtgtg  ttgccgtag  gcctttact  gccggcact  tgaaacctt  4140
gtcgatgtg  gtccccaga  gccctgcct  aatggaggg  cttgtgctg  ggccagtaa  4200
atgcctgat  gtttcattt  ccgttgtcc  ccgggattt  ccggggcaa  gtgccagag  4260
agctgtgga  aagtgaaat  taggaaggg  gagcagtgt  tgcacaccg  ctctggacc  4320
cgctgcttc  gccccagtc  ccgggactg  gagtcaggc  gtgccagta  cccctgcca  4380
cacgggggc  gctgccacc  tcagcgcca  cctccttat  actcctgcc  gtgtgcccc  4440
ccattctcg  gtagccgct  tgaactcta  acggcaccc  ccagcaccc  tcctgccac  4500
tgtctgagc  agtattgtg  cgacaaagc  cgggatggc  tctgtgatg  ggcctgcaa  4560
agccatgcc  gccagtggg  tgggggtga  tgttctctc  ccatggaga  cccctgggc  4620
aactgctcc  ccccacttc  ctgctggga  tatatcaac  accagtgtg  tgagctgtg  4680
aacacggtc  agtgcctgt  tgacaactt  gaatgccag  ggaacagca  gacatgcaa  4740
tatgacaaa  actgtgcag  ccacttcaa  gacaaccac  gtgaccagg  gtgcaacag  4800
gaggagtgt  gttgggatg  gctggactg  gctgctgac  aacctgaga  cctggcaga  4860
ggtaccctg  ttattgtgg  attgatgcc  cctgaacaa  tgctccagg  tgctcgcag  4920
ttcttgcgg  cactgggta  cctgctcca  accaacctg  gcattaagc  ggactccca  4980
ggggaactc  tggtgtacc  ctattatgg  gagaagtca  ctgctatga  gaaacagag  5040
atgacacgc  gatcccttc  tggtgaaca  gaacaggag  tggctggct  taaagtctt  5100
ctggaaatt  acaaccgcc  gtgtgttca  gactcagac  actgcttca  gaacacgga  5160
gcagcagca  ctctcctgg  ctctcacgc  atacagggg  ccctgtcat  ccctcttgt  5220
tctgtcgtc  gtgaatccc  gactccaga  cgcactcag  tcctctatc  ccttgctgt  5280
gctgttgtc  tcattctgt  tattattct  ctgggggta  tcatggcaa  acgaaagcg  5340
aagcatggc  ctctctggc  gcctgaagg  ttcactctt  gccgagatg  aagcaatca  5400
aagcgtcgt  agccagtgg  acaggatgc  gtggggctg  aaaatctct  agtgcaagt  5460
tcagaagct  acctaattg  tactggaac  agtgaacac  gggtcgatg  tgaagggcc  5520
cagccaaag  aagtaaagg  tgaagatga  gccttactc  cagaagaag  tgaccccat  5580
gatcgacgg  catggacac  gcagcacct  gaagctgca  acatccgta  gacaccatc  5640
ctggctctc  cccctcctc  ggcagagca  gaggtggat  tgttagatg  gaatgtccg  5700
ggcccagat  gctgcaccc  attgatgtt  gcttctctc  gaggaggca  ctcagattt  5760
agtgatgaa  atgaagatg  agaggactc  tctgctaac  tcatcacag  cttggtcta  5820
cagggtgcc  gcctccagg  ccagacaga  cggactggt  agatggccc  gcaccttgc  5880
gcccgctac  cacgggctg  tgctgccaa  cgtctcctg  atgcaggtg  agatgccaa  5940
gcccaggac  acatgggcc  ctgtccact  catgctgca  tggcagctg  tgcccaagg  6000
gtcttccag  ttctgattc  caaccgagt  actgatcta  atgccagga  gaatgatgg  6060
actacaccc  tgatcctgg  tgcccgcct  gctgtggag  gaatggtgg  agaactgat  6120
aactgccaa  cggatgtga  tgcagtgga  gaccatgga  aatctgctc  tcactgggc  6180
gctgctgtc  ataatgtgg  ggcaactct  ttgttgttg  aaaatgggg  caaccgaga  6240
atgcaggac  acaaggaag  gacacctct  tttcttgct  cccgggagg  gagctatga  6300
gcagccaag  tcctgttag  ccattttgc  aatcgagac  tcacagacc  tatggatcg  6360
cttccccgg  atgtggctc  ggatcgcat  caccatgac  ttgtgcgcc  tctggatga  6420
tacaatgtg  ccccaagcc  tccaggcac  gtgttgact  ctgctctct  acctgtcat  6480
tgtgggccc  acagatctt  cctcagcct  aagcacacc  caatgggca  gaagtctag  6540
cggcccagt  ccaagagta  catgcctac  agcctccct  accttgcca  ggaggcaaa  6600
gatgccaag  gtagtagga  gaagaagtc  ctgagtgag  aggtccaac  gtctgagag  6660
tcagtaact  tatcccctg  tgattccct  gaatctcct  acacgtatg  ttccgacac  6720
acatcctct  caatgatta  atcccctgg  atcttacag  cctcaccca  ccctatgtt  6780
gccactgcc  cccctcctg  cccagtcca  gcccagcat  cactatctt  ttctaacct  6840
catgaaatg  agcctttgg  acatggggc  agcactgtg  ttccctcag  gagccagtt  6900
ctatcccac  accacattg  gtctccagg  agtggcagt  ctggaagct  gagtaggct  6960
catccagtc  cagtcccag  agattggat  aaccgcatg  aggtgaatg  gacccagta  7020
aatgagatg  ttggtatgg  cctggctcc  gctgagggc  cccatcctg  catagctcc  7080
cagagcagg  cacctgaag  gaagcacat  accacccct  gggagccct  gccccccat  7140
gtgactttc  agctcatcc  taaaggcag  attgcccaa  cagcggggg  tccccagcc  7200
cagtccacc  gccctccag  tgttgcggg  cccctgccc  ccatgtacc  gattccaga  7260
atggcccgt  tgcccagtg  ggctttccc  actgccatg  tgccccagc  ggacgggca  7320
gtagctcag  ccattctcc  agcctatca  cctttccca  cctctgtgg  caagtaccc  7380
acaccccct  cacagcaca  ttatgcttc  tcaaatgct  ctgagcgaa  acccagtca  7440
agtggtcac  tccagggtg  gcatcccta  ctgacacca  ccccagagt  tcctgacca  7500
tggtcaagt  catcacccc  ctctgcttc  gactggtca  atgtgacca  cagccctac  7560
cctgggggt  ctggaggag  tcagcgggg  cctgggaca  acatgtctg  gccaccaca  7620
aacaacatg  aggtttatg  gtgagagag  ccacctcca  tgtagagac  taactgact  7680
ttgtaaatg  tgctgagga  caaatgaag  tcatccggg  gagaaatga  gaaatctct  7740
gagccagct  ctagaggta  gaaagagaa  atgttctta  tcagataat  caagagaag  7800
aattcgtca  tttcactgg  tatctgcaa  gcttattga  tattctaat  taataagac  7860
agtttgtgg  aatgcaaga  gaatacaag  cttgggtcc  tgtttactc  cttctattt  7920
gagaataag  tggatgctt  ttgaagccc  gacattctt  cagcttgga  tgcatttta  7980
gccctgcag  cttctgcca  atccatgag  agattctac  ctagcgtcc  gttgggaat  8040
atgccctgg  attctgcct  aattgacct  cgcatctcc  cctccttgg  cattctttt  8100
tcttcattt  gtgcttttg  ttttgcacc  ctccgtgat  gtagcccta  cagcatgtt  8160
tagggcaag  cctttgtgc  tttgatcat  ctggcccat  aaagcaact  tggtctcct  8220
tcccctcct  tcttcccgg  atcccttgg  gtctcacaa  gtttacttt  gtatggttc  8280
cagcacaaa  ctttcaagt  tgttgtttc  ttggaaaat  gacatactg  attgtgttc  8340
cctgcatat  tcattcctg  agagagaag  ggagaagaa  acttttctt  aacaaattt  8400
gggggcagg  gatcccttc  agaggctgc  ccttaattt  tcttgtctg  gtgcaggtc  8460
tcatataaa  tttaccagg  agaagggtg  gagtttgtt  tttttctgt  tatgggcct  8520
gtcagtgta  agttttatc  ttgatagtc  agttactat  accctcccc  cttttttaa  8580
accagaaaa  ggtttggaa  gttggaatg  ccaagagac  agttaactc  tgcaagagc  8640
agttaccca  ccacaggtc  ccctacttc  tgccaagca  tccattgac  gcctgtatg  8700
aacacattt  tcccagatc  gagcattct  ggcctgttt  actcactca  ccagcatat  8760
aaactagtc  taactgttg  gcctttcct  tcatatcca  agaagacac  gtctcaaat  8820
ttgtaccct  gccatttag  actgaactt  ccttagccc  agggaccca  tgacagttg  8880
cttccgttt  tcagatgat  agtctctac  gattatctt  ctgcttaaa  gcctgctca  8940
caatctttc  ttcacaccg  gtggtccgt  ttactggta  acccagtat  ttctcactg  9000
agacatgga  tttatatgt  caagtgcag  aattggaaa  ttggacttg  tttctatga  9060
ccaaaacag  cctataaga  ggttggaaa  ggaggaact  tatagcagc  tttgctatt  9120
tctgctacc  tttcttttc  tctgaagcg  ccatgacat  ccctttggc  actaacgta  9180
aaactcaac  gaacatttt  ctttcctag  gtcaccttt  agatgataa  ggacaacta  9240
agacttgct  attgttcag  ctgattgcc  ctcacctga  tccactctc  gtattcatg  9300
tcttggcaa  ttctttgac  ttcttttaa  ggcagaagc  ttttagtta  ttgtagata  9360
agaatagtt  tcttcctct  ctccttggg  cagttaata  ttggtccat  gctacactg  9420
aacttccgt  cagtgctgt  atgcccatg  cacctgcaa  ataagttct  cctgggcat  9480
ttgtagata  taacaggtg  attcccgac  cttttggtt  gaatgacag  tctcattcc  9540
tctatggct  caagtatgc  tcagtgctt  ccacttacc  gatttgtct  tcggtggcc  9600
catatggaa  ccctgcgtg  ctgttggca  aatagttta  aaatggttt  ttcagtcct  9660
tccaaattt  ttgaaccaa  aaaaataat  acttctgcc  tgagataag  agattaagt  9720
tgttcattc  ctgctttat  ctctccatg  ggcaacatt  tgtcagcct  tttcatagt  9780
tgcaaacat  ttatcattc  aaatggtga  tctctgccc  tggacccat  tattattca  9840
agatgggga  aacctatct  catggacct  tgtggacca  agcgtacct  cccctttct  9900
ccctcctgc  ccagcccca  ttctgaaag  atcagctac  gatccagcc  ctggatatt  9960
tatatcctc  cttttcctt  agcacaatg  cagaccaaa  tgcttgttt  tttttcttg  10020
actacttta  tttggatcc  ttgggtttg  agaaaggga  tgtgaaagc  gtcattaca  10080
acaacaggt  tcagtgatg  ggaggacaa  actgccttt  aaacttttt  ctgatctct  10140
agattttaa  aactcttga  ttgtgtggt  tctaataaa  gggaaggta  gatggataa  10200
cactttctc  tttgggttc  gaattggag  ctcagtttt  atgagacac  tcttttatg  10260
catgtatag  tcctcccct  ctatttttg  tttattttt  ttgttataa  tgctttctt  10320
ctttgactc  tcttctgcc  gcctttggg  ataggtttt  ttgtttgtt  atttgcttc  10380
tctgttttg  tttaagcat  attttctta  gtgaggtgg  gaagggaaa  gtatgaggg  10440
aagagagtc  gagaattaa  atattttag  ataagcaat  ggctgtgat  ctcaaatcc  10500
ttgcatcct  ttattgaat  tgccaattt  taatttttg  ataataaag  accaaaggt  10560
taatgtttt  ttgagaggt  gtttaggga  tttggccct  accaataca  tgaatgtat  10620
atgactatt  gggaggaca  atttatgta  ccagaggcc  ccactaata  gtggtacta  10680
ggttacttc  ttgtgtaca  ttctcttaa  agtgatatt  tatctgttt  tatgagaaa  10740
ccagtaacc  ataaaatga  cgcatattc  tgactaaac  tagtaagga  aatgcacac  10800
ttgttttta  ttttccgtt  cattctaaa  gtagttaag  tgaaattta  atgaaagca  10860
ttttatcac  aaataaaaa  ggtttgcca  gctcagtgg  gttgtattt  ttattttcc  10920
atactgcat  catggcctg  cagtgttac  tcatgatgt  ataatttgc  gagagagca  10980
attttcttt  ctttctgaa  cccacaaag  ctagcacca  acttctttt  ttcttcctt  11040
aattagatc  taaataaat  atcctgggg  aaaagcatc  gtcaaatag  aaacatcac  11100
aaactgagc  ctcttctgt  cactagcca  agctggtga  aaacagatg  ttgctcagg  11160
acaaggtgc  ttccaatgg  aatgcgaag  agttgctat  gcaagaatt  ggaactggg  11220
tataagtca  aatattaat  atgctgtta  gtaaatgat  ggtttgtaa  attccttaa  11280
tgaaatttg  gtagaactt  atatacagg  ttataaaat  atattttgt  tataaattt  11340
ttataagtt  acattcata  atttattta  aaagtcagt  agatatttg  acatg  11395



<210> 9651
<211> 2471
<212> PRT
<213> Homo sapiens
<308> XP_034671
<400> 9651

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
  1               5                  10                  15
Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
             20                  25                  30
Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
         35                  40                  45
Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
     50                  55                  60
Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
 65                  70                  75                  80
Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                 85                  90                  95
Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
             100                105                110
Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
         115                120                125
Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
     130                135                140
Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
 145                150                155                160
Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                 165                170                175
Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
             180                185                190
Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
         195                200                205
Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
     210                215                220
Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
 225                230                235                240
Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                 245                250                255
Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
             260                265                270
Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
         275                280                285
Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
     290                295                300
Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
 305                310                315                320
Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                 325                330                335
Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
             340                345                350
Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
         355                360                365
Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
     370                375                380
His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
 385                390                395                400
Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                 405                410                415
Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
             420                425                430
Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
         435                440                445
Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
     450                455                460
Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
 465                470                475                480
Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                 485                490                495
Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
             500                505                510
Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
         515                520                525
Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
     530                535                540
Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
 545                550                555                560
Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                 565                570                575
Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
             580                585                590
Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
         595                600                605
Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
     610                615                620
Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
 625                630                635                640
Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                 645                650                655
Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
             660                665                670
Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
         675                680                685
Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
     690                695                700
Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
 705                710                715                720
Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                 725                730                735
Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
             740                745                750
Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
         755                760                765
Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
     770                775                780
Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
 785                790                795                800
Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                 805                810                815
Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
             820                825                830
Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
         835                840                845
Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
     850                855                860
Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
 865                870                875                880
Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                 885                890                895
Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
             900                905                910
Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
         915                920                925
Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
     930                935                940
Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
 945                950                955                960
Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                 965                970                975
Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
             980                985                990
Glu Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser 
         995                1000                1005
Phe Ser Cys Leu Cys Pro Val Gly Phe Thr Gly Ser Phe Cys Leu His 
     1010                1015                1020
Glu Ile Asn Glu Cys Ser Ser His Pro Cys Leu Asn Glu Gly Thr Cys 
 1025                1030                1035                1040
Val Asp Gly Leu Gly Thr Tyr Arg Cys Ser Cys Pro Leu Gly Tyr Thr 
                 1045                1050                1055
Gly Lys Asn Cys Gln Thr Leu Val Asn Leu Cys Ser Arg Ser Pro Cys 
             1060                1065                1070
Lys Asn Lys Gly Thr Cys Val Gln Lys Lys Ala Glu Ser Gln Cys Leu 
         1075                1080                1085
Cys Pro Ser Gly Trp Ala Gly Ala Tyr Cys Asp Val Pro Asn Val Ser 
     1090                1095                1100
Cys Asp Ile Ala Ala Ser Arg Arg Gly Val Leu Val Glu His Leu Cys 
 1105                1110                1115                1120
Gln His Ser Gly Val Cys Ile Asn Ala Gly Asn Thr His Tyr Cys Gln 
                 1125                1130                1135
Cys Pro Leu Gly Tyr Thr Gly Ser Tyr Cys Glu Glu Gln Leu Asp Glu 
             1140                1145                1150
Cys Ala Ser Asn Pro Cys Gln His Gly Ala Thr Cys Ser Asp Phe Ile 
         1155                1160                1165
Gly Gly Tyr Arg Cys Glu Cys Val Pro Gly Tyr Gln Gly Val Asn Cys 
     1170                1175                1180
Glu Tyr Glu Val Asp Glu Cys Gln Asn Gln Pro Cys Gln Asn Gly Gly 
 1185                1190                1195                1200
Thr Cys Ile Asp Leu Val Asn His Phe Lys Cys Ser Cys Pro Pro Gly 
                 1205                1210                1215
Thr Arg Gly Leu Leu Cys Glu Glu Asn Ile Asp Asp Cys Ala Arg Gly 
             1220                1225                1230
Pro His Cys Leu Asn Gly Gly Gln Cys Met Asp Arg Ile Gly Gly Tyr 
         1235                1240                1245
Ser Cys Arg Cys Leu Pro Gly Phe Ala Gly Glu Arg Cys Glu Gly Asp 
     1250                1255                1260
Ile Asn Glu Cys Leu Ser Asn Pro Cys Ser Ser Glu Gly Ser Leu Asp 
 1265                1270                1275                1280
Cys Ile Gln Leu Thr Asn Asp Tyr Leu Cys Val Cys Arg Ser Ala Phe 
                 1285                1290                1295
Thr Gly Arg His Cys Glu Thr Phe Val Asp Val Cys Pro Gln Met Pro 
             1300                1305                1310
Cys Leu Asn Gly Gly Thr Cys Ala Val Ala Ser Asn Met Pro Asp Gly 
         1315                1320                1325
Phe Ile Cys Arg Cys Pro Pro Gly Phe Ser Gly Ala Arg Cys Gln Ser 
     1330                1335                1340
Ser Cys Gly Gln Val Lys Cys Arg Lys Gly Glu Gln Cys Val His Thr 
 1345                1350                1355                1360
Ala Ser Gly Pro Arg Cys Phe Cys Pro Ser Pro Arg Asp Cys Glu Ser 
                 1365                1370                1375
Gly Cys Ala Ser Ser Pro Cys Gln His Gly Gly Ser Cys His Pro Gln 
             1380                1385                1390
Arg Gln Pro Pro Tyr Tyr Ser Cys Gln Cys Ala Pro Pro Phe Ser Gly 
         1395                1400                1405
Ser Arg Cys Glu Leu Tyr Thr Ala Pro Pro Ser Thr Pro Pro Ala Thr 
     1410                1415                1420
Cys Leu Ser Gln Tyr Cys Ala Asp Lys Ala Arg Asp Gly Val Cys Asp 
 1425                1430                1435                1440
Glu Ala Cys Asn Ser His Ala Cys Gln Trp Asp Gly Gly Asp Cys Ser 
                 1445                1450                1455
Leu Thr Met Glu Asn Pro Trp Ala Asn Cys Ser Ser Pro Leu Pro Cys 
             1460                1465                1470
Trp Asp Tyr Ile Asn Asn Gln Cys Asp Glu Leu Cys Asn Thr Val Glu 
         1475                1480                1485
Cys Leu Phe Asp Asn Phe Glu Cys Gln Gly Asn Ser Lys Thr Cys Lys 
     1490                1495                1500
Tyr Asp Lys Tyr Cys Ala Asp His Phe Lys Asp Asn His Cys Asp Gln 
 1505                1510                1515                1520
Gly Cys Asn Ser Glu Glu Cys Gly Trp Asp Gly Leu Asp Cys Ala Ala 
                 1525                1530                1535
Asp Gln Pro Glu Asn Leu Ala Glu Gly Thr Leu Val Ile Val Val Leu 
             1540                1545                1550
Met Pro Pro Glu Gln Leu Leu Gln Asp Ala Arg Ser Phe Leu Arg Ala 
         1555                1560                1565
Leu Gly Thr Leu Leu His Thr Asn Leu Arg Ile Lys Arg Asp Ser Gln 
     1570                1575                1580
Gly Glu Leu Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met 
 1585                1590                1595                1600
Lys Lys Gln Arg Met Thr Arg Arg Ser Leu Pro Gly Glu Gln Glu Gln 
                 1605                1610                1615
Glu Val Ala Gly Ser Lys Val Phe Leu Glu Ile Asp Asn Arg Gln Cys 
             1620                1625                1630
Val Gln Asp Ser Asp His Cys Phe Lys Asn Thr Asp Ala Ala Ala Ala 
         1635                1640                1645
Leu Leu Ala Ser His Ala Ile Gln Gly Thr Leu Ser Tyr Pro Leu Val 
     1650                1655                1660
Ser Val Val Ser Glu Ser Leu Thr Pro Glu Arg Thr Gln Leu Leu Tyr 
 1665                1670                1675                1680
Leu Leu Ala Val Ala Val Val Ile Ile Leu Phe Ile Ile Leu Leu Gly 
                 1685                1690                1695
Val Ile Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro 
             1700                1705                1710
Glu Gly Phe Thr Leu Arg Arg Asp Ala Ser Asn His Lys Arg Arg Glu 
         1715                1720                1725
Pro Val Gly Gln Asp Ala Val Gly Leu Lys Asn Leu Ser Val Gln Val 
     1730                1735                1740
Ser Glu Ala Asn Leu Ile Gly Thr Gly Thr Ser Glu His Trp Val Asp 
 1745                1750                1755                1760
Asp Glu Gly Pro Gln Pro Lys Lys Val Lys Ala Glu Asp Glu Ala Leu 
                 1765                1770                1775
Leu Ser Glu Glu Asp Asp Pro Ile Asp Arg Arg Pro Trp Thr Gln Gln 
             1780                1785                1790
His Leu Glu Ala Ala Asp Ile Arg Arg Thr Pro Ser Leu Ala Leu Thr 
         1795                1800                1805
Pro Pro Gln Ala Glu Gln Glu Val Asp Val Leu Asp Val Asn Val Arg 
     1810                1815                1820
Gly Pro Asp Gly Cys Thr Pro Leu Met Leu Ala Ser Leu Arg Gly Gly 
 1825                1830                1835                1840
Ser Ser Asp Leu Ser Asp Glu Asp Glu Asp Ala Glu Asp Ser Ser Ala 
                 1845                1850                1855
Asn Ile Ile Thr Asp Leu Val Tyr Gln Gly Ala Ser Leu Gln Ala Gln 
             1860                1865                1870
Thr Asp Arg Thr Gly Glu Met Ala Leu His Leu Ala Ala Arg Tyr Ser 
         1875                1880                1885
Arg Ala Asp Ala Ala Lys Arg Leu Leu Asp Ala Gly Ala Asp Ala Asn 
     1890                1895                1900
Ala Gln Asp Asn Met Gly Arg Cys Pro Leu His Ala Ala Val Ala Ala 
 1905                1910                1915                1920
Asp Ala Gln Gly Val Phe Gln Ile Leu Ile Arg Asn Arg Val Thr Asp 
                 1925                1930                1935
Leu Asp Ala Arg Met Asn Asp Gly Thr Thr Pro Leu Ile Leu Ala Ala 
             1940                1945                1950
Arg Leu Ala Val Glu Gly Met Val Ala Glu Leu Ile Asn Cys Gln Ala 
         1955                1960                1965
Asp Val Asn Ala Val Asp Asp His Gly Lys Ser Ala Leu His Trp Ala 
     1970                1975                1980
Ala Ala Val Asn Asn Val Glu Ala Thr Leu Leu Leu Leu Lys Asn Gly 
 1985                1990                1995                2000
Ala Asn Arg Asp Met Gln Asp Asn Lys Glu Glu Thr Pro Leu Phe Leu 
                 2005                2010                2015
Ala Ala Arg Glu Gly Ser Tyr Glu Ala Ala Lys Ile Leu Leu Asp His 
             2020                2025                2030
Phe Ala Asn Arg Asp Ile Thr Asp His Met Asp Arg Leu Pro Arg Asp 
         2035                2040                2045
Val Ala Arg Asp Arg Met His His Asp Ile Val Arg Leu Leu Asp Glu 
     2050                2055                2060
Tyr Asn Val Thr Pro Ser Pro Pro Gly Thr Val Leu Thr Ser Ala Leu 
 2065                2070                2075                2080
Ser Pro Val Ile Cys Gly Pro Asn Arg Ser Phe Leu Ser Leu Lys His 
                 2085                2090                2095
Thr Pro Met Gly Lys Lys Ser Arg Arg Pro Ser Ala Lys Ser Thr Met 
             2100                2105                2110
Pro Thr Ser Leu Pro Asn Leu Ala Lys Glu Ala Lys Asp Ala Lys Gly 
         2115                2120                2125
Ser Arg Arg Lys Lys Ser Leu Ser Glu Lys Val Gln Leu Ser Glu Ser 
     2130                2135                2140
Ser Val Thr Leu Ser Pro Val Asp Ser Leu Glu Ser Pro His Thr Tyr 
 2145                2150                2155                2160
Val Ser Asp Thr Thr Ser Ser Pro Met Ile Thr Ser Pro Gly Ile Leu 
                 2165                2170                2175
Gln Ala Ser Pro Asn Pro Met Leu Ala Thr Ala Ala Pro Pro Ala Pro 
             2180                2185                2190
Val His Ala Gln His Ala Leu Ser Phe Ser Asn Leu His Glu Met Gln 
         2195                2200                2205
Pro Leu Ala His Gly Ala Ser Thr Val Leu Pro Ser Val Ser Gln Leu 
     2210                2215                2220
Leu Ser His His His Ile Val Ser Pro Gly Ser Gly Ser Ala Gly Ser 
 2225                2230                2235                2240
Leu Ser Arg Leu His Pro Val Pro Val Pro Ala Asp Trp Met Asn Arg 
                 2245                2250                2255
Met Glu Val Asn Glu Thr Gln Tyr Asn Glu Met Phe Gly Met Val Leu 
             2260                2265                2270
Ala Pro Ala Glu Gly Thr His Pro Gly Ile Ala Pro Gln Ser Arg Pro 
         2275                2280                2285
Pro Glu Gly Lys His Ile Thr Thr Pro Arg Glu Pro Leu Pro Pro Ile 
     2290                2295                2300
Val Thr Phe Gln Leu Ile Pro Lys Gly Ser Ile Ala Gln Pro Ala Gly 
 2305                2310                2315                2320
Ala Pro Gln Pro Gln Ser Thr Cys Pro Pro Ala Val Ala Gly Pro Leu 
                 2325                2330                2335
Pro Thr Met Tyr Gln Ile Pro Glu Met Ala Arg Leu Pro Ser Val Ala 
             2340                2345                2350
Phe Pro Thr Ala Met Met Pro Gln Gln Asp Gly Gln Val Ala Gln Thr 
         2355                2360                2365
Ile Leu Pro Ala Tyr His Pro Phe Pro Ala Ser Val Gly Lys Tyr Pro 
     2370                2375                2380
Thr Pro Pro Ser Gln His Ser Tyr Ala Ser Ser Asn Ala Ala Glu Arg 
 2385                2390                2395                2400
Thr Pro Ser His Ser Gly His Leu Gln Gly Glu His Pro Tyr Leu Thr 
                 2405                2410                2415
Pro Ser Pro Glu Ser Pro Asp Gln Trp Ser Ser Ser Ser Pro His Ser 
             2420                2425                2430
Ala Ser Asp Trp Ser Asp Val Thr Thr Ser Pro Thr Pro Gly Gly Ala 
         2435                2440                2445
Gly Gly Gly Gln Arg Gly Pro Gly Thr His Met Ser Glu Pro Pro His 
     2450                2455                2460
Asn Asn Met Gln Val Tyr Ala 
 2465                2470



<210> 9652
<211> 8221
<212> DNA
<213> Rattus norvegicus
<308> X57405
<400> 9652

ggcgggtca  ggagcgcag  ggcgtgggg  gcagggccg  gtgcagcgc  gtgaaggaa  60
gagcctggg  tgccctgta  tgccgggga  accctgaga  cccagcccg  ccacccgcc  120
ggaaagagg  cagcagcgg  tggaacgcc  gcgggaccg  ccgtggtgc  cgtgaacgt  180
cgatcccgg  cggccaccg  aagaggccg  cgcccggca  cgggcagct  gcgagcagg  240
atgccgcgg  tcctggcgc  cttgctctg  ctaacgctg  tgcccgcgc  cgccgcaag  300
ggcttgaga  gctcccagc  aagtgggac  tgcctgaat  gagggaggt  cgaagtggc  360
aacggcact  aagcctgtg  ctgcagcgg  gcgttcgtg  gccagcgat  ccaggaccc  420
agcccttgc  tcagcacac  atgtaagaa  gctggaacg  gctatgttg  ggaccatgg  480
ggcatcgtg  actatgcct  cagttgccc  ctgggtttc  ctgggcccc  ctgcctgac  540
cctctggcc  atgcctgcc  ggccaaccc  tgccgcaac  gggggacct  tgacctgct  600
actctcaca  aatacaagt  ccggtgccc  ccagggtgg  caggaaagt  atgtcagca  660
gccgacccc  gtgcctcca  cccctgtgc  aatggtggc  agtgcctgc  ctttgagtc  720
tcatacatc  gtggctgcc  gcccggctt  catggcccc  cctgcagac  agatgttaa  780
gagtgcagc  agaaccctg  gttgtgccg  catgggggc  cgtgccaca  tgagattgg  840
tcctatcgc  gtgcctgcc  tgccaccca  actggtccc  actgcgagc  gccctacgt  900
ccctgcagc  cctcaccct  ccagaacgg  ggcacctgc  gccctacgg  ggacaccac  960
cacgagtgt  cctgcctgc  aggctttgc  ggacagaac  gtgaagaaa  tgtggatga  1020
tgcccagga  acaactgca  gaacggggg  gcctgtgtg  acggtgtga  tacctacaa  1080
tgccgctgc  caccggagt  gacaggtca  tactgcaca  aggatgtgg  cgagtgtca  1140
ctcatgccc  acgcctgcc  gaatgcggg  acctgccac  actcccacg  tggctacaa  1200
tgcgtgtgt  tcaatggct  gactggtga  gactgcagt  acaacattg  tgactgtgc  1260
agtgccgcc  gttttcagg  tgccacctg  catgaccgt  tggcttcct  ctactgcga  1320
tgtccacat  ggcgcacag  cctgctgtg  cacctgaac  atgcgtgta  cagcaaccc  1380
tgcaacgag  gctccaact  cgacaccaa  cctgtcaac  gcaaggcca  ctgcacttg  1440
cctcggggg  acacggggc  agcctgcag  caggacgtg  atgagtgcg  tctaggtgc  1500
aacccgtgt  agcacgcgg  caagtgcct  aacacactg  gctctttcg  gtgtcagtg  1560
ctacagggc  acactgggc  ccgctgtga  attgatgtc  acgagtgca  ctccaaccc  1620
tgtcagaat  atgccacgt  cctggacca  attggggag  ttcagtgta  atgtatgcc  1680
ggttatgag  gtgtatact  tgagatcaa  acggacgag  gtgccagca  cccctgtct  1740
cacaatggc  gctgcgtgg  caagatcaa  gagttcctg  gtcagtgtc  caaaggctt  1800
agcgggcac  tgtgccagt  tgacgtgga  gagtgcgcc  gcacaccat  caagaacgg  1860
gccaagtgc  tggatgggc  caacaccta  acctgcgtg  gcacagaag  ttacacggg  1920
acccactgc  aggtggaca  tgacgagtg  gaccctgac  cctgtcaca  tggtttgtg  1980
aaggatggt  tggccacct  tacctgcct  tgccagcca  gctacacag  ccatcactg  2040
gagaccaac  ttaatgagt  tcacagcca  ccgtgccgc  atggcggca  ctgccagga  2100
cgtgacaac  actacctct  cttatgcct  aaggggacc  caggaccca  ctgtgagat  2160
aatctggat  actgtgcga  caacccctg  gactctggc  cgtgtctgg  caagatcga  2220
ggctacgag  gtgcgtgcg  gccaggcta  acagggagc  tgtgtaatg  caacattga  2280
gaatgtgcg  gcagcccct  ccacaacgg  ggcacctgt  aggatggca  cgccggctt  2340
acttgccgc  gccccgagg  ctaccacga  cctacgtgc  tgtctgagg  caacgagtg  2400
aacagtaac  cctgcatcc  tggagcttg  cgggatggc  tcaatggat  caaatgtga  2460
tgtgcccct  ggtggagtg  gacaaactg  gacatcaac  acaatgagt  tgagtccaa  2520
ccttgtgtc  acggtggca  ctgcaaaga  atgaccagt  gctacgtat  cacctgccg  2580
gaaggcttc  gtggcccta  ctgccagac  aacattaac  aatgtgctt  caacccctg  2640
ctgaaccag  gcacctgca  tgatgatgt  gctgggtac  aatgcaact  ccctctgcc  2700
tatacagga  ccacatgtg  ggtggtgtt  gccccatgt  ccaccagcc  ctgcaaaaa  2760
agtggggta  gcaaggagt  tgaggacta  gagagcttt  cctgtgtct  tcccacagg  2820
tggcaaggt  aaacctgcg  gatcgacat  aatgagtgt  tgaaaagcc  gtgtcgcca  2880
ggtgcctct  gccagaaca  caatggcag  taccgctgc  tctgccagg  tggctacac  2940
ggtcgcaac  gcgagagtg  catcgatga  tgccgaccc  acccatgtc  caacggggg  3000
tcctgcact  acggggtca  cgcggcctt  tgcgactgc  tgcccggct  ccagggtgc  3060
ttctgtgag  aggacatca  cgaatgcgc  acgaatcca  gccaaaatg  cgccaactg  3120
actgactgc  tggacagct  cacgtgcac  tgccccacc  ggttcaatg  catccattg  3180
gagaacaac  cacctgact  taccgagag  tcctgtttc  atggtggca  ctgtgtgga  3240
ggtatcaac  ccttcacct  tctgtgccc  cctggcttc  cgggcagct  ctgccagta  3300
gacgtcaat  agtgtgact  acggccctg  ctgcatggt  gcacctgcc  agacagcta  3360
ggtacctat  agtgtacct  cccacaggg  tacactggt  tcaactgcc  gaaccttgt  3420
cgctggtgt  actcagctc  ctgcaagaa  ggcggcaag  gctggcaga  caacacaca  3480
taccactgc  agtgccgca  cggctggac  ggcttcaac  gcgacgtgc  cagtgtgtc  3540
tgcgaggtg  ctgcacaga  gcgaggcat  gatgtcact  tcctatgcc  gcacggagg  3600
ctctgtgtg  atgaggaag  caagcatta  tgccactgc  aggcaggat  cacgggcag  3660
tactgtgag  acgaggtgg  cgagtgctc  cctaatccc  gccagaacg  agccacctg  3720
actgactat  tcggtggct  ttcctgcaa  tgtgtggct  ggtaccatg  ctctaactg  3780
tctgaggag  tcaacgagt  cctatccca  ccctgccag  atgggggta  ctgcattga  3840
ctgaccaac  cctacaagt  ctcctgccc  aggggcaca  agggtgtac  ctgtgagat  3900
aacgtcgat  actgccatc  tcccctaga  cctgcttcc  gaagcccca  atgcttcaa  3960
aatggcacc  gcgtggacc  ggtgggtgg  tatacctgc  cctgcccgc  aggcttcgt  4020
ggggagcgg  gcgagggcg  tgtcaatga  tgtctctcc  acccctgtg  cccacgtgg  4080
acccagaac  gcgtgcagc  tgttaatga  ttccactgc  agtgccggg  tggccacac  4140
ggacgccgc  gtgagtcgg  cattaatgg  tgcaggggc  aaccatgca  gaatggagg  4200
gtctgtgct  tggcctcca  caccgcccg  ggattcatc  gtaggtgcc  tgcccgctt  4260
gagggtgcc  cttgtgaaa  tgacgcccg  acttgtggc  gtttgcgct  cctcaacgg  4320
ggtacgtgc  tctcaggcc  acgcagtcc  acctgccta  gcctgggct  cttcactgg  4380
cctgaatgc  agttcccag  cagcagccc  tgtgtgggt  gcaacccct  ctacaatca  4440
ggcacctgt  agcccacat  cgagagccc  ttctaccgc  gtctatgcc  tgccaaatt  4500
aacgggctg  tgtgccaca  cctggacta  agcttcaca  gtgcggccg  gcgcgacat  4560
cccccgcca  agattgagg  ggcctgcga  ctgcctgag  gccaggagg  tgcaggcaa  4620
aaggtctgc  accttcagt  taataatca  gcgtgtggc  gggacggcg  cgactgctc  4680
ctcaacttc  atgaccctt  gaagaactg  actcagtcc  tgcagtgct  gaagtattt  4740
agtgacggc  actgtgaca  ccagtgcaa  tcagctggc  gcctttttg  tggcttcga  4800
tgccagctc  ccgagggac  gtgcaaccc  ctgtatgac  agtactgca  ggaccactt  4860
agtgatggc  actgcgacc  gggctgcaa  agtgccgag  gtgagtggg  tggactgga  4920
tgtgcagag  atgtccccg  gcgactggc  gccggcaca  tggtgctgg  ggtgctgct  4980
ccgcccgat  agctacgca  caactcctt  cacttcctg  gggacgtca  ccacgtgct  5040
cacaccaac  tggtcttca  gcgtgacgc  cagggccag  agatgatct  cccctacta  5100
ggccgcgag  aagagctac  caagcaccc  atcaagcgt  ctgcagtgg  ctgggccac  5160
acgtcactg  ttcctggca  caatggtgg  cgccagcgc  gggagctgg  ccccatgga  5220
atccatggc  ccatcgtct  cctggagat  gacaaccgg  agtgtgtac  gtcatcctc  5280
caatgcttc  agagcgcca  cgatgtggc  gccttccta  gtgctcttg  ctccctcgg  5340
agcctcaat  tcccctaca  gatcgaagc  gtaaagagt  agacggtgg  gcctccgct  5400
ccctcacag  tgcacctca  gtacgtggc  gcagctgcc  tcgtgctcc  gttctttgt  5460
ggctgtggg  tgctgctgt  ccgcaagcg  aggcggcag  atggccagc  ctggttccc  5520
gagggtttc  aagtgtcag  ggccagcaa  aagaagcgg  gagaacccc  cggcgagga  5580
tcagtcggc  tcaagcccc  gaagaacgc  tcagatggt  ccctgatgg  cgacaatca  5640
aacgagtgg  gggacgaag  cctggagac  aagaagttc  ggtttgagg  accagtggt  5700
ctccctgac  tggatgatc  gactgacca  cggcagtgg  cccagcagc  cctggatgc  5760
gctgaccta  gtgtgtctg  catggcccc  acgccgcct  agggggagg  agatgctga  5820
tgcatggac  tcaatgttc  aggaccaga  ggcttcact  ccctaatga  tgcctcctg  5880
agcggaggg  gcctggaga  aggcaacag  gaggaagaa  aagatgcac  tgctgtcat  5940
tccgacttc  tctatcagg  tgccagctt  cacaaccag  cggaccgca  aggggagac  6000
gccctgcac  tggctgccc  atactctcg  tcagatgct  ccaagcgct  gctggaggc  6060
agcgcagat  ccaacatcc  agacaacat  gggcgtacc  cattacatg  cgctgtttc  6120
gcagacgct  agggtgtct  ccagatcct  ctccggaac  gagccacag  tctggatgc  6180
cgaatgcat  atggcacaa  ccctctgat  ctggcggca  gcctggccg  ggaaggcat  6240
ctagaggac  tcatcaact  tcacgctga  gtcaatgct  tggatgacc  aggcaagtc  6300
gctctgcac  gggcagccg  tgtgaacaa  gtggacgct  ctgttgtgc  cctgaagaa  6360
ggagccaac  aagacatgc  gaacaacaa  gaggagact  ccctgttcc  ggccgcccg  6420
gagggcagc  atgagactg  caaagtgtt  ctggaccac  ttgccaacc  ggacatcac  6480
gatcacatg  accgattgc  acgggacat  gcacaggag  gcatgcacc  cgatatcgt  6540
cggcttttg  atgaataca  cctggtgcg  agcccacag  tgcatggca  tgccttggg  6600
ggcacaccc  ctctgtctc  cacactctg  tcgcccaac  gctacctgg  caacctcaa  6660
tctgccaca  agggcaaga  ggcccgaaa  cccagcacc  aagggctgg  ttgcagtag  6720
aaggaagct  aggacctca  ggcccggag  aagaagtcc  aggatggca  gggctgcct  6780
ttggacagc  caagcatgc  gtcacccgt  gactccctc  agtcacccc  tggctactt  6840
tcagatgtg  cctcaccac  cctccttcc  tccccgttc  agcagtctc  atccatgcc  6900
ctcagccac  tgccaggta  gcctgacac  cacctgggc  tcagccact  gaatgtggc  6960
gccaagccc  agatggcag  tctggccgg  ggcagccgg  tggcctttg  gccaccccc  7020
ccacgcctc  cccacctgc  tgtagcctc  agtgccagc  cagtgctga  taccaatgg  7080
acaggggct  tgaatttca  cgtgggtgc  ccggcaagc  tgaatggcc  gtgtgagtg  7140
cttccccgg  tccagaatg  catggtgcc  agccagtac  acccgctaa  gccaggtgt  7200
actccgggc  cactaagca  acaggcagc  ggcctccag  atggcatga  gggcccgat  7260
cacagcagc  tctccacca  taccttgtc  ccgattatc  accagggcc  gcccaacac  7320
aggctggcc  cacagcccc  cctggtgca  acccagcag  tgcagccac  gaacttaca  7380
atccagcct  agaacctgc  gccaccatc  cagccacac  tcagtgtga  ctcagcagc  7440
aatgggcac  tgggtcgga  cttcctgag  ggggagccc  gccaggcag  cgtacagcc  7500
ctgggcccc  gcagtctgc  tgtgcacac  attctgccc  aggaaagcc  ggctctgcc  7560
acatcactg  catcctcca  ggtcccacc  atgaccact  cccagttcc  gacccctcc  7620
tctcagcac  gctactcat  ctcacctgt  gacaacacc  ccagccacc  gctgcaggt  7680
ccagagcac  ccttcctca  cccatcccc  gagtcccct  accagtggt  cagctcctc  7740
cggcattcc  acatctctg  ttggtccga  ggcatctct  gcccgccca  gagcatgcc  7800
tcccagatc  cccacattc  agaggcatt  aagtaaaca  agatgtggg  tgaaggacc  7860
cagcttccg  tcccaagct  tgttgggag  cctttccag  gctccagga  gctggggcg  7920
ccaaaggag  cttttaaaa  aaaatgttt  tatacaaaa  aagaggaca  gaatttcca  7980
ttttttttt  gtatttatt  atgtacttt  attttccac  gaaacactg  ctttttatt  8040
atatgtatt  ttttctatg  cactagggg  aaacatctg  tccaagaaa  taaactagt  8100
ctgagagcc  cgattttcc  ggtcagggt  aagttccct  tgtgtttgt  aaatacgaa  8160
aaggattca  gatttgtaa  tgccgttta  ttattgatt  cttctttcc  aaatcgtcg  8220
g  8221



<210> 9653
<211> 2531
<212> PRT
<213> Rattus norvegicus
<308> CAA40667
<400> 9653

Met Pro Arg Leu Leu Ala Pro Leu Leu Cys Leu Thr Leu Leu Pro Ala 
  1               5                  10                  15
Leu Ala Ala Arg Gly Leu Arg Cys Ser Gln Pro Ser Gly Thr Cys Leu 
             20                  25                  30
Asn Gly Gly Arg Cys Glu Val Ala Asn Gly Thr Glu Ala Cys Val Cys 
         35                  40                  45
Ser Gly Ala Phe Val Gly Gln Arg Cys Gln Asp Pro Ser Pro Cys Leu 
     50                  55                  60
Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys Tyr Val Val Asp His Gly 
 65                  70                  75                  80
Gly Ile Val Asp Tyr Ala Cys Ser Cys Pro Leu Gly Phe Ser Gly Pro 
                 85                  90                  95
Leu Cys Leu Thr Pro Leu Ala Asn Ala Cys Leu Ala Asn Pro Cys Arg 
             100                105                110
Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
         115                120                125
Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
     130                135                140
Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ser 
 145                150                155                160
Ser Tyr Ile Cys Gly Cys Pro Pro Gly Phe His Gly Pro Thr Cys Arg 
                 165                170                175
Gln Asp Val Asn Glu Cys Ser Gln Asn Pro Gly Leu Cys Arg His Gly 
             180                185                190
Gly Thr Cys His Asn Glu Ile Gly Ser Tyr Arg Cys Ala Cys Arg Ala 
         195                200                205
Thr His Thr Gly Pro His Cys Glu Leu Pro Tyr Val Pro Cys Ser Pro 
     210                215                220
Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Thr Thr 
 225                230                235                240
His Glu Cys Ala Cys Leu Pro Gly Phe Ala Gly Gln Asn Cys Glu Glu 
                 245                250                255
Asn Val Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
             260                265                270
Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
         275                280                285
Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
     290                295                300
Ala Cys Gln Asn Ala Gly Thr Cys His Asn Ser His Gly Gly Tyr Asn 
 305                310                315                320
Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Asp Asn Ile 
                 325                330                335
Asp Asp Cys Ala Ser Ala Ala Cys Phe Gln Gly Ala Thr Cys His Asp 
             340                345                350
Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
         355                360                365
Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
     370                375                380
Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
 385                390                395                400
Pro Arg Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                 405                410                415
Ala Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Leu Asn Thr 
             420                425                430
Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
         435                440                445
Cys Glu Ile Asp Val Asn Glu Cys Ile Ser Asn Pro Cys Gln Asn Asp 
     450                455                460
Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
 465                470                475                480
Gly Tyr Glu Gly Val Tyr Cys Glu Ile Asn Thr Asp Glu Cys Ala Ser 
                 485                490                495
Ser Pro Cys Leu His Asn Gly Arg Cys Val Asp Lys Ile Asn Glu Phe 
             500                505                510
Leu Cys Gln Cys Pro Lys Gly Phe Ser Gly His Leu Cys Gln Tyr Asp 
         515                520                525
Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
     530                535                540
Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
 545                550                555                560
Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                 565                570                575
Ile Gly Leu Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Gln 
             580                585                590
Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys His 
         595                600                605
Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Tyr 
     610                615                620
Tyr Leu Cys Leu Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
 625                630                635                640
Asn Leu Asp Asp Cys Ala Ser Asn Pro Cys Asp Ser Gly Thr Cys Leu 
                 645                650                655
Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
             660                665                670
Ser Met Cys Asn Val Asn Ile Asp Glu Cys Ala Gly Ser Pro Cys His 
         675                680                685
Asn Gly Gly Thr Cys Glu Asp Gly Ile Ala Gly Phe Thr Cys Arg Cys 
     690                695                700
Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
 705                710                715                720
Asn Ser Asn Pro Cys Ile His Gly Ala Cys Arg Asp Gly Leu Asn Gly 
                 725                730                735
Tyr Lys Cys Asp Cys Ala Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
             740                745                750
Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
         755                760                765
Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
     770                775                780
Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
 785                790                795                800
Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                 805                810                815
Cys Pro Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
             820                825                830
Cys Ala Thr Ser Pro Cys Lys Asn Ser Gly Val Cys Lys Glu Ser Glu 
         835                840                845
Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
     850                855                860
Thr Cys Glu Ile Asp Ile Asn Glu Cys Val Lys Ser Pro Cys Arg His 
 865                870                875                880
Gly Ala Ser Cys Gln Asn Thr Asn Gly Ser Tyr Arg Cys Leu Cys Gln 
                 885                890                895
Ala Gly Tyr Thr Gly Arg Asn Cys Glu Ser Asp Ile Asp Asp Cys Arg 
             900                905                910
Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Val Asn Ala 
         915                920                925
Ala Phe Cys Asp Cys Leu Pro Gly Phe Gln Gly Ala Phe Cys Glu Glu 
     930                935                940
Asp Ile Asn Glu Cys Ala Thr Asn Pro Cys Gln Asn Gly Ala Asn Cys 
 945                950                955                960
Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Thr Gly Phe Asn 
                 965                970                975
Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
             980                985                990
Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser Phe Thr Cys Leu 
         995                1000                1005
Cys Pro Pro Gly Phe Thr Gly Ser Tyr Cys Gln Tyr Asp Val Asn Glu 
     1010                1015                1020
Cys Asp Ser Arg Pro Cys Leu His Gly Gly Thr Cys Gln Asp Ser Tyr 
 1025                1030                1035                1040
Gly Thr Tyr Lys Cys Thr Cys Pro Gln Gly Tyr Thr Gly Leu Asn Cys 
                 1045                1050                1055
Gln Asn Leu Val Arg Trp Cys Asp Ser Ala Pro Cys Lys Asn Gly Gly 
             1060                1065                1070
Lys Cys Trp Gln Thr Asn Thr Gln Tyr His Cys Glu Cys Arg Ser Gly 
         1075                1080                1085
Trp Thr Gly Phe Asn Cys Asp Val Leu Ser Val Ser Cys Glu Val Ala 
     1090                1095                1100
Ala Gln Lys Arg Gly Ile Asp Val Thr Leu Leu Cys Gln His Gly Gly 
 1105                1110                1115                1120
Leu Cys Val Asp Glu Glu Asp Lys His Tyr Cys His Cys Gln Ala Gly 
                 1125                1130                1135
Tyr Thr Gly Ser Tyr Cys Glu Asp Glu Val Asp Glu Cys Ser Pro Asn 
             1140                1145                1150
Pro Cys Gln Asn Gly Ala Thr Cys Thr Asp Tyr Leu Gly Gly Phe Ser 
         1155                1160                1165
Cys Lys Cys Val Ala Gly Tyr His Gly Ser Asn Cys Ser Glu Glu Ile 
     1170                1175                1180
Asn Glu Cys Leu Ser Gln Pro Cys Gln Asn Gly Gly Thr Cys Ile Asp 
 1185                1190                1195                1200
Leu Thr Asn Thr Tyr Lys Cys Ser Cys Pro Arg Gly Thr Gln Gly Val 
                 1205                1210                1215
His Cys Glu Ile Asn Val Asp Asp Cys His Pro Pro Leu Asp Pro Ala 
             1220                1225                1230
Ser Arg Ser Pro Lys Cys Phe Asn Asn Gly Thr Cys Val Asp Gln Val 
         1235                1240                1245
Gly Gly Tyr Thr Cys Thr Cys Pro Pro Gly Phe Val Gly Glu Arg Cys 
     1250                1255                1260
Glu Gly Asp Val Asn Glu Cys Leu Ser Asn Pro Cys Asp Pro Arg Gly 
 1265                1270                1275                1280
Thr Gln Asn Cys Val Gln Arg Val Asn Asp Phe His Cys Glu Cys Arg 
                 1285                1290                1295
Ala Gly His Thr Gly Arg Arg Cys Glu Ser Val Ile Asn Gly Cys Arg 
             1300                1305                1310
Gly Lys Pro Cys Arg Asn Gly Gly Val Cys Ala Val Ala Ser Asn Thr 
         1315                1320                1325
Ala Arg Gly Phe Ile Cys Arg Cys Pro Ala Arg Phe Glu Gly Ala Thr 
     1330                1335                1340
Cys Glu Asn Asp Ala Arg Thr Cys Gly Ser Leu Arg Cys Leu Asn Gly 
 1345                1350                1355                1360
Gly Thr Cys Ile Ser Gly Pro Arg Ser Pro Thr Cys Leu Cys Leu Gly 
                 1365                1370                1375
Ser Phe Thr Gly Pro Glu Cys Gln Phe Pro Ala Ser Ser Pro Cys Val 
             1380                1385                1390
Gly Ser Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro Thr Ser Glu 
         1395                1400                1405
Ser Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn Gly Leu Leu 
     1410                1415                1420
Cys His Ile Leu Asp Tyr Ser Phe Thr Gly Ala Ala Gly Arg Asp Ile 
 1425                1430                1435                1440
Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Glu 
                 1445                1450                1455
Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys 
             1460                1465                1470
Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys 
         1475                1480                1485
Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His 
     1490                1495                1500
Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp 
 1505                1510                1515                1520
Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys 
                 1525                1530                1535
Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala 
             1540                1545                1550
Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg 
         1555                1560                1565
Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln 
     1570                1575                1580
Leu Arg Asn Asn Ser Phe His Phe Leu Arg Asp Val Ser His Val Leu 
 1585                1590                1595                1600
His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile 
                 1605                1610                1615
Phe Pro Tyr Tyr Gly Arg Glu Glu Glu Leu Arg Lys His Pro Ile Lys 
             1620                1625                1630
Arg Ser Ala Val Gly Trp Ala Thr Thr Ser Leu Leu Pro Gly Thr Asn 
         1635                1640                1645
Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile His Gly Ser 
     1650                1655                1660
Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser 
 1665                1670                1675                1680
Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu 
                 1685                1690                1695
Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys 
             1700                1705                1710
Ser Glu Thr Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr 
         1715                1720                1725
Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val 
     1730                1735                1740
Leu Leu Ser Arg Lys Arg Arg Arg Gln His Gly Gln Leu Trp Phe Pro 
 1745                1750                1755                1760
Glu Gly Phe Lys Val Ser Glu Ala Ser Lys Lys Lys Arg Arg Glu Pro 
                 1765                1770                1775
Leu Gly Glu Asp Ser Val Gly Leu Lys Pro Leu Lys Asn Ala Ser Asp 
             1780                1785                1790
Gly Ala Leu Met Asp Asp Asn Gln Asn Glu Trp Gly Asp Glu Asp Leu 
         1795                1800                1805
Glu Thr Lys Lys Phe Arg Phe Glu Glu Pro Val Val Leu Pro Asp Leu 
     1810                1815                1820
Asp Asp Gln Thr Asp His Arg Gln Trp Thr Gln Gln His Leu Asp Ala 
 1825                1830                1835                1840
Ala Asp Leu Arg Val Ser Ala Met Ala Pro Thr Pro Pro Gln Gly Glu 
                 1845                1850                1855
Val Asp Ala Asp Cys Met Asp Val Asn Val Arg Gly Pro Asp Gly Phe 
             1860                1865                1870
Thr Pro Leu Met Ile Ala Ser Cys Ser Gly Gly Gly Leu Glu Thr Gly 
         1875                1880                1885
Asn Ser Glu Glu Glu Glu Asp Ala Pro Ala Val Ile Ser Asp Phe Ile 
     1890                1895                1900
Tyr Gln Gly Ala Ser Leu His Asn Gln Thr Asp Arg Thr Gly Glu Thr 
 1905                1910                1915                1920
Ala Leu His Leu Ala Ala Arg Tyr Ser Arg Ser Asp Ala Ala Lys Arg 
                 1925                1930                1935
Leu Leu Glu Ala Ser Ala Asp Ala Asn Ile Gln Asp Asn Met Gly Arg 
             1940                1945                1950
Thr Pro Leu His Ala Ala Val Ser Ala Asp Ala Gln Gly Val Phe Gln 
         1955                1960                1965
Ile Leu Leu Arg Asn Arg Ala Thr Asp Leu Asp Ala Arg Met His Asp 
     1970                1975                1980
Gly Thr Thr Pro Leu Ile Leu Ala Ala Arg Leu Ala Val Glu Gly Met 
 1985                1990                1995                2000
Leu Glu Asp Leu Ile Asn Ser His Ala Asp Val Asn Ala Val Asp Asp 
                 2005                2010                2015
Leu Gly Lys Ser Ala Leu His Trp Ala Ala Ala Val Asn Asn Val Asp 
             2020                2025                2030
Ala Ala Val Val Leu Leu Lys Asn Gly Ala Asn Lys Asp Met Gln Asn 
         2035                2040                2045
Asn Lys Glu Glu Thr Pro Leu Phe Leu Ala Ala Arg Glu Gly Ser Tyr 
     2050                2055                2060
Glu Thr Ala Lys Val Leu Leu Asp His Phe Ala Asn Arg Asp Ile Thr 
 2065                2070                2075                2080
Asp His Met Asp Arg Leu Pro Arg Asp Ile Ala Gln Glu Arg Met His 
                 2085                2090                2095
His Asp Ile Val Arg Leu Leu Asp Glu Tyr Asn Leu Val Arg Ser Pro 
             2100                2105                2110
Gln Leu His Gly Thr Ala Leu Gly Gly Thr Pro Thr Leu Ser Pro Thr 
         2115                2120                2125
Leu Cys Ser Pro Asn Gly Tyr Leu Gly Asn Leu Lys Ser Ala Thr Gln 
     2130                2135                2140
Gly Lys Lys Ala Arg Lys Pro Ser Thr Lys Gly Leu Ala Cys Ser Ser 
 2145                2150                2155                2160
Lys Glu Ala Lys Asp Leu Lys Ala Arg Arg Lys Lys Ser Gln Asp Gly 
                 2165                2170                2175
Lys Gly Cys Leu Leu Asp Ser Ser Ser Met Leu Ser Pro Val Asp Ser 
             2180                2185                2190
Leu Glu Ser Pro His Gly Tyr Leu Ser Asp Val Ala Ser Pro Pro Leu 
         2195                2200                2205
Leu Pro Ser Pro Phe Gln Gln Ser Pro Ser Met Pro Leu Ser His Leu 
     2210                2215                2220
Pro Gly Met Pro Asp Thr His Leu Gly Ile Ser His Leu Asn Val Ala 
 2225                2230                2235                2240
Ala Lys Pro Glu Met Ala Ala Leu Ala Gly Gly Ser Arg Leu Ala Phe 
                 2245                2250                2255
Glu Pro Pro Pro Pro Arg Leu Ser His Leu Pro Val Ala Ser Ser Ala 
             2260                2265                2270
Ser Thr Val Leu Ser Thr Asn Gly Thr Gly Ala Met Asn Phe Thr Val 
         2275                2280                2285
Gly Ala Pro Ala Ser Leu Asn Gly Gln Cys Glu Trp Leu Pro Arg Leu 
     2290                2295                2300
Gln Asn Gly Met Val Pro Ser Gln Tyr Asn Pro Leu Arg Pro Gly Val 
 2305                2310                2315                2320
Thr Pro Gly Thr Leu Ser Thr Gln Ala Ala Gly Leu Gln His Gly Met 
                 2325                2330                2335
Met Gly Pro Ile His Ser Ser Leu Ser Thr Asn Thr Leu Ser Pro Ile 
             2340                2345                2350
Ile Tyr Gln Gly Leu Pro Asn Thr Arg Leu Ala Thr Gln Pro His Leu 
         2355                2360                2365
Val Gln Thr Gln Gln Val Gln Pro Gln Asn Leu Gln Ile Gln Pro Gln 
     2370                2375                2380
Asn Leu Gln Pro Pro Ser Gln Pro His Leu Ser Val Ser Ser Ala Ala 
 2385                2390                2395                2400
Asn Gly His Leu Gly Arg Ser Phe Leu Ser Gly Glu Pro Ser Gln Ala 
                 2405                2410                2415
Asp Val Gln Pro Leu Gly Pro Ser Ser Leu Pro Val His Thr Ile Leu 
             2420                2425                2430
Pro Gln Glu Ser Gln Ala Leu Pro Thr Ser Leu Pro Ser Ser Met Val 
         2435                2440                2445
Pro Pro Met Thr Thr Thr Gln Phe Leu Thr Pro Pro Ser Gln His Ser 
     2450                2455                2460
Tyr Ser Ser Ser Pro Val Asp Asn Thr Pro Ser His Gln Leu Gln Val 
 2465                2470                2475                2480
Pro Glu His Pro Phe Leu Thr Pro Ser Pro Glu Ser Pro Asp Gln Trp 
                 2485                2490                2495
Ser Ser Ser Ser Arg His Ser Asn Ile Ser Asp Trp Ser Glu Gly Ile 
             2500                2505                2510
Ser Ser Pro Pro Thr Ser Met Pro Ser Gln Ile Thr His Ile Pro Glu 
         2515                2520                2525
Ala Phe Lys 
     2530



<210> 9654
<211> 11395
<212> DNA
<213> Homo sapiens
<308> XM_034671
<400> 9654

tttcagcca  acttcgggc  gcggctgag  cggcggccg  ggagcggcg  actcggggc  60
cggggagtc  aggcatttg  gcctgggct  cggagcgta  cgccagggc  tgagccttt  120
aagcaggag  aggggagga  agagtgggg  tcctctatc  ggaccccct  cccatgtgg  180
tctgcccag  cggcggcgg  ggcggcgga  gaggaggcg  ccgagaaga  gcccgccct  240
cgccccgct  tgctgtggg  gctgctggc  ctctggctg  gctgcgcgg  ccccgcgca  300
gcattgcag  gtcgagatg  ctatgaacc  tgtgtaaat  aaggaatgt  tgttaccta  360
cacaatggc  caggatact  caaatgtcc  gaaggcttc  tgggggaat  ttgtcaaca  420
cgagacccc  gtgagaaga  ccgctgcca  aatggtggg  cttgtgtgg  ccaggccat  480
ctggggaaa  ccacgtgcc  atgtgcctc  gggtttaca  gagaggact  ccagtactc  540
acatctcat  catgctttg  gtctcgacc  tgcctgaat  gcggcacat  ccatatgct  600
agccgggat  cctatgagt  cacctgtca  gtcgggttt  caggtaagg  gtgccaatg  660
acggatgcc  gcctgtctc  tccctgtgc  aatggaagt  cctgtacca  tgtggccaa  720
cagttctcc  gcaaatgcc  cacaggctt  acagggcag  aatgtgaga  tgatgtcaa  780
gagtgtgac  ttccaggac  ctgccagca  ggtggcacc  gcctcaacc  gcctggttc  840
taccagtgc  agtgccctc  gggcttcac  ggccagtac  gtgacagcc  gtatgtgcc  900
tgtgcaccc  caccttgtg  caatggagg  acctgtcgg  agactggtg  cttcacttt  960
gagtgcaac  gccttccag  ttttgaagg  agcacctgt  agaggaata  tgatgactg  1020
cctaaccac  ggtgtcaga  tggaggggt  tgtgtggat  gggtcaaca  ttacaactg  1080
cgctgtccc  cacaatgga  aggacagtt  tgcacagag  atgtggatg  atgcctgct  1140
cagcccaat  cctgtcaaa  tgggggcac  tgtgccaac  gcaatggag  ctatggctg  1200
gtatgtgtc  acggctgga  tggagatga  tgcagtgag  acattgatg  ttgtgcctt  1260
gcctcctgt  ctccaggct  cacctgcat  gaccgtgtg  cctccttct  ttgcatgtg  1320
ccagagggg  aggcaggtc  cctgtgtca  ctggatgat  catgcatca  caatccttg  1380
cacaagggg  cactgtgtg  caccaaccc  ctaaatggg  aatatattt  cacctgccc  1440
caaggctac  aaggggctg  ctgcacaga  gatgtggat  aatgtgcca  ggccaatag  1500
aatccttgt  agcatgcag  aaaatgtgt  aacacggat  gcgccttcc  ctgtgagtg  1560
ctgaagggt  atgcaggac  tcgttgtga  atggacatc  atgagtgcc  ttcagaccc  1620
tgccagaat  atgctacct  tctggataa  attggaggc  tcacatgtc  gtgcatgcc  1680
ggtttcaaa  gtgtgcatt  tgaattaga  ataaatgaa  gtcagagca  cccttgtgt  1740
aacaatggg  agtgtgtgg  taaagtcaa  cgtttccag  gcctgtgtc  tcctggttt  1800
actgggcca  tttgccaga  tgatattga  gactgttcc  gtactccgt  tctgaatgg  1860
gcaaagtgt  tcgatcacc  gaatggcta  gaatgccag  gtgccacag  tttcactgg  1920
gtgttgtgt  aggagaaca  tgacaactg  gaccccgat  cttgccacc  tggtcagtg  1980
caggatggt  ttgattcct  cacctgcat  tgcaatccc  ggtacatgg  cgccatctg  2040
agtgaccag  ttgatgaat  ttacagcag  ccttgcctg  acgatggtc  ctgcattga  2100
ctggtcaat  gctaccagt  caactgcca  ccaggcacg  caggggtta  ttgtgaaat  2160
aattttgat  actgtgcaa  taacccttg  atccatgga  tctgtatgg  tggcattaa  2220
cgctacagt  gtgtctgct  accaggatt  acagggcag  gatgtaaca  tgacattga  2280
gagtgtgcc  ccaatccct  tcgcaaggg  gcaacatgt  tcaacggtg  gaatggttt  2340
cgctgtata  gccccgagg  accccatca  cccagctgc  actcacagg  gaacgaatg  2400
ctgagcaat  cctgcatcc  tggaaactg  actggaggt  tcagtggat  taagtgtct  2460
tgtgatgca  gctgggttg  catcaactg  gaagtggac  aaaatgaat  cctttcgaa  2520
ccatgccag  atggaggaa  ttgtgacaa  ctggtgaat  gatacaggt  tacttgcaa  2580
aagggcttt  aaggctata  ctgccaggt  aatattgat  aatgtgcct  aaatccatg  2640
ctgaaccaa  gaacctgct  tgatgacat  agtggctac  cttgccact  tgtgctgcc  2700
tacacaggc  agaattgtc  gacagtatt  gctccctgt  ccccaaacc  ttgtgagaa  2760
gctgctgtt  gcaaagagt  accaaattt  gagagttat  cttgcttgt  tgctcctgg  2820
tggcaaggt  agcggtgta  cattgacat  gacgagtgt  tctccaagc  ctgcatgaa  2880
catggtctc  gccataaca  ccagggcag  tacatgtgt  aatgtccac  aggcttcag  2940
ggtatggac  gtgaggagg  cattgatga  tgccttgcc  atccttgcc  gaatggagg  3000
tcctgtatg  atggagtga  tactttctc  tgcctctgc  ttccgggtt  cactgggga  3060
aagtgccag  cagacatga  tgagtgtct  agtgaaccc  gtaagaatg  agggacctg  3120
tctgactac  tcaacagtt  cacttgcaa  tgccaggca  gatttgatg  agtccattg  3180
gagaacaac  tcaatgagt  cactgagag  tcctgtttc  atggtggca  atgtgttga  3240
gggattaac  ccttctctt  cttgtgccc  gtgggtttc  ctggatcct  ctgcctcca  3300
gagatcaat  aatgcagct  tcatccatg  ctgaatgag  gaacgtgtg  tgatggcct  3360
ggtacctac  gctgcagct  ccccctggg  tacactggg  aaaactgtc  gaccctggt  3420
aatctctgc  gtcggtctc  atgtaaaaa  aaaggtact  gcgttcaga  aaaagcaga  3480
tcccagtgc  tatgtccat  tggatgggc  ggtgcctat  gtgacgtgc  caatgtctc  3540
tgtgacata  cagcctcca  gagaggtgt  cttgttgaa  acttgtgcc  gcactcagg  3600
gtctgcatc  atgctggca  cacgcatta  tgtcagtgc  ccctgggct  tactgggag  3660
tactgtgag  agcaactcg  tgagtgtgc  tccaacccc  gccagcacg  ggcaacatg  3720
agtgacttc  ttggtggat  cagatgcga  tgtgtccca  gctatcagg  tgtcaactg  3780
gagtatgaa  tggatgagt  ccagaatca  ccctgccag  atggaggca  ctgtattga  3840
cttgtgaac  atttcaagt  ctcttgccc  ccaggcact  ggggcctac  ctgtgaaga  3900
aacattgat  actgtgccc  gggtcccca  tgccttaat  gtggtcagt  catggatag  3960
attggaggc  acagttgtc  ctgcttgcc  ggctttgct  gggagcgtt  tgagggaga  4020
atcaacgag  gcctctcca  cccctgcag  tctgagggc  gcctggact  tatacagct  4080
accaatgac  acctgtgtg  ttgccgtag  gcctttact  gccggcact  tgaaacctt  4140
gtcgatgtg  gtccccaga  gccctgcct  aatggaggg  cttgtgctg  ggccagtaa  4200
atgcctgat  gtttcattt  ccgttgtcc  ccgggattt  ccggggcaa  gtgccagag  4260
agctgtgga  aagtgaaat  taggaaggg  gagcagtgt  tgcacaccg  ctctggacc  4320
cgctgcttc  gccccagtc  ccgggactg  gagtcaggc  gtgccagta  cccctgcca  4380
cacgggggc  gctgccacc  tcagcgcca  cctccttat  actcctgcc  gtgtgcccc  4440
ccattctcg  gtagccgct  tgaactcta  acggcaccc  ccagcaccc  tcctgccac  4500
tgtctgagc  agtattgtg  cgacaaagc  cgggatggc  tctgtgatg  ggcctgcaa  4560
agccatgcc  gccagtggg  tgggggtga  tgttctctc  ccatggaga  cccctgggc  4620
aactgctcc  ccccacttc  ctgctggga  tatatcaac  accagtgtg  tgagctgtg  4680
aacacggtc  agtgcctgt  tgacaactt  gaatgccag  ggaacagca  gacatgcaa  4740
tatgacaaa  actgtgcag  ccacttcaa  gacaaccac  gtgaccagg  gtgcaacag  4800
gaggagtgt  gttgggatg  gctggactg  gctgctgac  aacctgaga  cctggcaga  4860
ggtaccctg  ttattgtgg  attgatgcc  cctgaacaa  tgctccagg  tgctcgcag  4920
ttcttgcgg  cactgggta  cctgctcca  accaacctg  gcattaagc  ggactccca  4980
ggggaactc  tggtgtacc  ctattatgg  gagaagtca  ctgctatga  gaaacagag  5040
atgacacgc  gatcccttc  tggtgaaca  gaacaggag  tggctggct  taaagtctt  5100
ctggaaatt  acaaccgcc  gtgtgttca  gactcagac  actgcttca  gaacacgga  5160
gcagcagca  ctctcctgg  ctctcacgc  atacagggg  ccctgtcat  ccctcttgt  5220
tctgtcgtc  gtgaatccc  gactccaga  cgcactcag  tcctctatc  ccttgctgt  5280
gctgttgtc  tcattctgt  tattattct  ctgggggta  tcatggcaa  acgaaagcg  5340
aagcatggc  ctctctggc  gcctgaagg  ttcactctt  gccgagatg  aagcaatca  5400
aagcgtcgt  agccagtgg  acaggatgc  gtggggctg  aaaatctct  agtgcaagt  5460
tcagaagct  acctaattg  tactggaac  agtgaacac  gggtcgatg  tgaagggcc  5520
cagccaaag  aagtaaagg  tgaagatga  gccttactc  cagaagaag  tgaccccat  5580
gatcgacgg  catggacac  gcagcacct  gaagctgca  acatccgta  gacaccatc  5640
ctggctctc  cccctcctc  ggcagagca  gaggtggat  tgttagatg  gaatgtccg  5700
ggcccagat  gctgcaccc  attgatgtt  gcttctctc  gaggaggca  ctcagattt  5760
agtgatgaa  atgaagatg  agaggactc  tctgctaac  tcatcacag  cttggtcta  5820
cagggtgcc  gcctccagg  ccagacaga  cggactggt  agatggccc  gcaccttgc  5880
gcccgctac  cacgggctg  tgctgccaa  cgtctcctg  atgcaggtg  agatgccaa  5940
gcccaggac  acatgggcc  ctgtccact  catgctgca  tggcagctg  tgcccaagg  6000
gtcttccag  ttctgattc  caaccgagt  actgatcta  atgccagga  gaatgatgg  6060
actacaccc  tgatcctgg  tgcccgcct  gctgtggag  gaatggtgg  agaactgat  6120
aactgccaa  cggatgtga  tgcagtgga  gaccatgga  aatctgctc  tcactgggc  6180
gctgctgtc  ataatgtgg  ggcaactct  ttgttgttg  aaaatgggg  caaccgaga  6240
atgcaggac  acaaggaag  gacacctct  tttcttgct  cccgggagg  gagctatga  6300
gcagccaag  tcctgttag  ccattttgc  aatcgagac  tcacagacc  tatggatcg  6360
cttccccgg  atgtggctc  ggatcgcat  caccatgac  ttgtgcgcc  tctggatga  6420
tacaatgtg  ccccaagcc  tccaggcac  gtgttgact  ctgctctct  acctgtcat  6480
tgtgggccc  acagatctt  cctcagcct  aagcacacc  caatgggca  gaagtctag  6540
cggcccagt  ccaagagta  catgcctac  agcctccct  accttgcca  ggaggcaaa  6600
gatgccaag  gtagtagga  gaagaagtc  ctgagtgag  aggtccaac  gtctgagag  6660
tcagtaact  tatcccctg  tgattccct  gaatctcct  acacgtatg  ttccgacac  6720
acatcctct  caatgatta  atcccctgg  atcttacag  cctcaccca  ccctatgtt  6780
gccactgcc  cccctcctg  cccagtcca  gcccagcat  cactatctt  ttctaacct  6840
catgaaatg  agcctttgg  acatggggc  agcactgtg  ttccctcag  gagccagtt  6900
ctatcccac  accacattg  gtctccagg  agtggcagt  ctggaagct  gagtaggct  6960
catccagtc  cagtcccag  agattggat  aaccgcatg  aggtgaatg  gacccagta  7020
aatgagatg  ttggtatgg  cctggctcc  gctgagggc  cccatcctg  catagctcc  7080
cagagcagg  cacctgaag  gaagcacat  accacccct  gggagccct  gccccccat  7140
gtgactttc  agctcatcc  taaaggcag  attgcccaa  cagcggggg  tccccagcc  7200
cagtccacc  gccctccag  tgttgcggg  cccctgccc  ccatgtacc  gattccaga  7260
atggcccgt  tgcccagtg  ggctttccc  actgccatg  tgccccagc  ggacgggca  7320
gtagctcag  ccattctcc  agcctatca  cctttccca  cctctgtgg  caagtaccc  7380
acaccccct  cacagcaca  ttatgcttc  tcaaatgct  ctgagcgaa  acccagtca  7440
agtggtcac  tccagggtg  gcatcccta  ctgacacca  ccccagagt  tcctgacca  7500
tggtcaagt  catcacccc  ctctgcttc  gactggtca  atgtgacca  cagccctac  7560
cctgggggt  ctggaggag  tcagcgggg  cctgggaca  acatgtctg  gccaccaca  7620
aacaacatg  aggtttatg  gtgagagag  ccacctcca  tgtagagac  taactgact  7680
ttgtaaatg  tgctgagga  caaatgaag  tcatccggg  gagaaatga  gaaatctct  7740
gagccagct  ctagaggta  gaaagagaa  atgttctta  tcagataat  caagagaag  7800
aattcgtca  tttcactgg  tatctgcaa  gcttattga  tattctaat  taataagac  7860
agtttgtgg  aatgcaaga  gaatacaag  cttgggtcc  tgtttactc  cttctattt  7920
gagaataag  tggatgctt  ttgaagccc  gacattctt  cagcttgga  tgcatttta  7980
gccctgcag  cttctgcca  atccatgag  agattctac  ctagcgtcc  gttgggaat  8040
atgccctgg  attctgcct  aattgacct  cgcatctcc  cctccttgg  cattctttt  8100
tcttcattt  gtgcttttg  ttttgcacc  ctccgtgat  gtagcccta  cagcatgtt  8160
tagggcaag  cctttgtgc  tttgatcat  ctggcccat  aaagcaact  tggtctcct  8220
tcccctcct  tcttcccgg  atcccttgg  gtctcacaa  gtttacttt  gtatggttc  8280
cagcacaaa  ctttcaagt  tgttgtttc  ttggaaaat  gacatactg  attgtgttc  8340
cctgcatat  tcattcctg  agagagaag  ggagaagaa  acttttctt  aacaaattt  8400
gggggcagg  gatcccttc  agaggctgc  ccttaattt  tcttgtctg  gtgcaggtc  8460
tcatataaa  tttaccagg  agaagggtg  gagtttgtt  tttttctgt  tatgggcct  8520
gtcagtgta  agttttatc  ttgatagtc  agttactat  accctcccc  cttttttaa  8580
accagaaaa  ggtttggaa  gttggaatg  ccaagagac  agttaactc  tgcaagagc  8640
agttaccca  ccacaggtc  ccctacttc  tgccaagca  tccattgac  gcctgtatg  8700
aacacattt  tcccagatc  gagcattct  ggcctgttt  actcactca  ccagcatat  8760
aaactagtc  taactgttg  gcctttcct  tcatatcca  agaagacac  gtctcaaat  8820
ttgtaccct  gccatttag  actgaactt  ccttagccc  agggaccca  tgacagttg  8880
cttccgttt  tcagatgat  agtctctac  gattatctt  ctgcttaaa  gcctgctca  8940
caatctttc  ttcacaccg  gtggtccgt  ttactggta  acccagtat  ttctcactg  9000
agacatgga  tttatatgt  caagtgcag  aattggaaa  ttggacttg  tttctatga  9060
ccaaaacag  cctataaga  ggttggaaa  ggaggaact  tatagcagc  tttgctatt  9120
tctgctacc  tttcttttc  tctgaagcg  ccatgacat  ccctttggc  actaacgta  9180
aaactcaac  gaacatttt  ctttcctag  gtcaccttt  agatgataa  ggacaacta  9240
agacttgct  attgttcag  ctgattgcc  ctcacctga  tccactctc  gtattcatg  9300
tcttggcaa  ttctttgac  ttcttttaa  ggcagaagc  ttttagtta  ttgtagata  9360
agaatagtt  tcttcctct  ctccttggg  cagttaata  ttggtccat  gctacactg  9420
aacttccgt  cagtgctgt  atgcccatg  cacctgcaa  ataagttct  cctgggcat  9480
ttgtagata  taacaggtg  attcccgac  cttttggtt  gaatgacag  tctcattcc  9540
tctatggct  caagtatgc  tcagtgctt  ccacttacc  gatttgtct  tcggtggcc  9600
catatggaa  ccctgcgtg  ctgttggca  aatagttta  aaatggttt  ttcagtcct  9660
tccaaattt  ttgaaccaa  aaaaataat  acttctgcc  tgagataag  agattaagt  9720
tgttcattc  ctgctttat  ctctccatg  ggcaacatt  tgtcagcct  tttcatagt  9780
tgcaaacat  ttatcattc  aaatggtga  tctctgccc  tggacccat  tattattca  9840
agatgggga  aacctatct  catggacct  tgtggacca  agcgtacct  cccctttct  9900
ccctcctgc  ccagcccca  ttctgaaag  atcagctac  gatccagcc  ctggatatt  9960
tatatcctc  cttttcctt  agcacaatg  cagaccaaa  tgcttgttt  tttttcttg  10020
actacttta  tttggatcc  ttgggtttg  agaaaggga  tgtgaaagc  gtcattaca  10080
acaacaggt  tcagtgatg  ggaggacaa  actgccttt  aaacttttt  ctgatctct  10140
agattttaa  aactcttga  ttgtgtggt  tctaataaa  gggaaggta  gatggataa  10200
cactttctc  tttgggttc  gaattggag  ctcagtttt  atgagacac  tcttttatg  10260
catgtatag  tcctcccct  ctatttttg  tttattttt  ttgttataa  tgctttctt  10320
ctttgactc  tcttctgcc  gcctttggg  ataggtttt  ttgtttgtt  atttgcttc  10380
tctgttttg  tttaagcat  attttctta  gtgaggtgg  gaagggaaa  gtatgaggg  10440
aagagagtc  gagaattaa  atattttag  ataagcaat  ggctgtgat  ctcaaatcc  10500
ttgcatcct  ttattgaat  tgccaattt  taatttttg  ataataaag  accaaaggt  10560
taatgtttt  ttgagaggt  gtttaggga  tttggccct  accaataca  tgaatgtat  10620
atgactatt  gggaggaca  atttatgta  ccagaggcc  ccactaata  gtggtacta  10680
ggttacttc  ttgtgtaca  ttctcttaa  agtgatatt  tatctgttt  tatgagaaa  10740
ccagtaacc  ataaaatga  cgcatattc  tgactaaac  tagtaagga  aatgcacac  10800
ttgttttta  ttttccgtt  cattctaaa  gtagttaag  tgaaattta  atgaaagca  10860
ttttatcac  aaataaaaa  ggtttgcca  gctcagtgg  gttgtattt  ttattttcc  10920
atactgcat  catggcctg  cagtgttac  tcatgatgt  ataatttgc  gagagagca  10980
attttcttt  ctttctgaa  cccacaaag  ctagcacca  acttctttt  ttcttcctt  11040
aattagatc  taaataaat  atcctgggg  aaaagcatc  gtcaaatag  aaacatcac  11100
aaactgagc  ctcttctgt  cactagcca  agctggtga  aaacagatg  ttgctcagg  11160
acaaggtgc  ttccaatgg  aatgcgaag  agttgctat  gcaagaatt  ggaactggg  11220
tataagtca  aatattaat  atgctgtta  gtaaatgat  ggtttgtaa  attccttaa  11280
tgaaatttg  gtagaactt  atatacagg  ttataaaat  atattttgt  tataaattt  11340
ttataagtt  acattcata  atttattta  aaagtcagt  agatatttg  acatg  11395



<210> 9655
<211> 2471
<212> PRT
<213> Homo sapiens
<308> XP_034671
<400> 9655

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
  1               5                  10                  15
Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
             20                  25                  30
Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
         35                  40                  45
Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
     50                  55                  60
Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
 65                  70                  75                  80
Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                 85                  90                  95
Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
             100                105                110
Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
         115                120                125
Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
     130                135                140
Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
 145                150                155                160
Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                 165                170                175
Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
             180                185                190
Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
         195                200                205
Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
     210                215                220
Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
 225                230                235                240
Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                 245                250                255
Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
             260                265                270
Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
         275                280                285
Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
     290                295                300
Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
 305                310                315                320
Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                 325                330                335
Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
             340                345                350
Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
         355                360                365
Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
     370                375                380
His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
 385                390                395                400
Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                 405                410                415
Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
             420                425                430
Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
         435                440                445
Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
     450                455                460
Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
 465                470                475                480
Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                 485                490                495
Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
             500                505                510
Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
         515                520                525
Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
     530                535                540
Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
 545                550                555                560
Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                 565                570                575
Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
             580                585                590
Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
         595                600                605
Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
     610                615                620
Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
 625                630                635                640
Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                 645                650                655
Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
             660                665                670
Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
         675                680                685
Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
     690                695                700
Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
 705                710                715                720
Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                 725                730                735
Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
             740                745                750
Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
         755                760                765
Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
     770                775                780
Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
 785                790                795                800
Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                 805                810                815
Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
             820                825                830
Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
         835                840                845
Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
     850                855                860
Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
 865                870                875                880
Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                 885                890                895
Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
             900                905                910
Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
         915                920                925
Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
     930                935                940
Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
 945                950                955                960
Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                 965                970                975
Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
             980                985                990
Glu Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser 
         995                1000                1005
Phe Ser Cys Leu Cys Pro Val Gly Phe Thr Gly Ser Phe Cys Leu His 
     1010                1015                1020
Glu Ile Asn Glu Cys Ser Ser His Pro Cys Leu Asn Glu Gly Thr Cys 
 1025                1030                1035                1040
Val Asp Gly Leu Gly Thr Tyr Arg Cys Ser Cys Pro Leu Gly Tyr Thr 
                 1045                1050                1055
Gly Lys Asn Cys Gln Thr Leu Val Asn Leu Cys Ser Arg Ser Pro Cys 
             1060                1065                1070
Lys Asn Lys Gly Thr Cys Val Gln Lys Lys Ala Glu Ser Gln Cys Leu 
         1075                1080                1085
Cys Pro Ser Gly Trp Ala Gly Ala Tyr Cys Asp Val Pro Asn Val Ser 
     1090                1095                1100
Cys Asp Ile Ala Ala Ser Arg Arg Gly Val Leu Val Glu His Leu Cys 
 1105                1110                1115                1120
Gln His Ser Gly Val Cys Ile Asn Ala Gly Asn Thr His Tyr Cys Gln 
                 1125                1130                1135
Cys Pro Leu Gly Tyr Thr Gly Ser Tyr Cys Glu Glu Gln Leu Asp Glu 
             1140                1145                1150
Cys Ala Ser Asn Pro Cys Gln His Gly Ala Thr Cys Ser Asp Phe Ile 
         1155                1160                1165
Gly Gly Tyr Arg Cys Glu Cys Val Pro Gly Tyr Gln Gly Val Asn Cys 
     1170                1175                1180
Glu Tyr Glu Val Asp Glu Cys Gln Asn Gln Pro Cys Gln Asn Gly Gly 
 1185                1190                1195                1200
Thr Cys Ile Asp Leu Val Asn His Phe Lys Cys Ser Cys Pro Pro Gly 
                 1205                1210                1215
Thr Arg Gly Leu Leu Cys Glu Glu Asn Ile Asp Asp Cys Ala Arg Gly 
             1220                1225                1230
Pro His Cys Leu Asn Gly Gly Gln Cys Met Asp Arg Ile Gly Gly Tyr 
         1235                1240                1245
Ser Cys Arg Cys Leu Pro Gly Phe Ala Gly Glu Arg Cys Glu Gly Asp 
     1250                1255                1260
Ile Asn Glu Cys Leu Ser Asn Pro Cys Ser Ser Glu Gly Ser Leu Asp 
 1265                1270                1275                1280
Cys Ile Gln Leu Thr Asn Asp Tyr Leu Cys Val Cys Arg Ser Ala Phe 
                 1285                1290                1295
Thr Gly Arg His Cys Glu Thr Phe Val Asp Val Cys Pro Gln Met Pro 
             1300                1305                1310
Cys Leu Asn Gly Gly Thr Cys Ala Val Ala Ser Asn Met Pro Asp Gly 
         1315                1320                1325
Phe Ile Cys Arg Cys Pro Pro Gly Phe Ser Gly Ala Arg Cys Gln Ser 
     1330                1335                1340
Ser Cys Gly Gln Val Lys Cys Arg Lys Gly Glu Gln Cys Val His Thr 
 1345                1350                1355                1360
Ala Ser Gly Pro Arg Cys Phe Cys Pro Ser Pro Arg Asp Cys Glu Ser 
                 1365                1370                1375
Gly Cys Ala Ser Ser Pro Cys Gln His Gly Gly Ser Cys His Pro Gln 
             1380                1385                1390
Arg Gln Pro Pro Tyr Tyr Ser Cys Gln Cys Ala Pro Pro Phe Ser Gly 
         1395                1400                1405
Ser Arg Cys Glu Leu Tyr Thr Ala Pro Pro Ser Thr Pro Pro Ala Thr 
     1410                1415                1420
Cys Leu Ser Gln Tyr Cys Ala Asp Lys Ala Arg Asp Gly Val Cys Asp 
 1425                1430                1435                1440
Glu Ala Cys Asn Ser His Ala Cys Gln Trp Asp Gly Gly Asp Cys Ser 
                 1445                1450                1455
Leu Thr Met Glu Asn Pro Trp Ala Asn Cys Ser Ser Pro Leu Pro Cys 
             1460                1465                1470
Trp Asp Tyr Ile Asn Asn Gln Cys Asp Glu Leu Cys Asn Thr Val Glu 
         1475                1480                1485
Cys Leu Phe Asp Asn Phe Glu Cys Gln Gly Asn Ser Lys Thr Cys Lys 
     1490                1495                1500
Tyr Asp Lys Tyr Cys Ala Asp His Phe Lys Asp Asn His Cys Asp Gln 
 1505                1510                1515                1520
Gly Cys Asn Ser Glu Glu Cys Gly Trp Asp Gly Leu Asp Cys Ala Ala 
                 1525                1530                1535
Asp Gln Pro Glu Asn Leu Ala Glu Gly Thr Leu Val Ile Val Val Leu 
             1540                1545                1550
Met Pro Pro Glu Gln Leu Leu Gln Asp Ala Arg Ser Phe Leu Arg Ala 
         1555                1560                1565
Leu Gly Thr Leu Leu His Thr Asn Leu Arg Ile Lys Arg Asp Ser Gln 
     1570                1575                1580
Gly Glu Leu Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met 
 1585                1590                1595                1600
Lys Lys Gln Arg Met Thr Arg Arg Ser Leu Pro Gly Glu Gln Glu Gln 
                 1605                1610                1615
Glu Val Ala Gly Ser Lys Val Phe Leu Glu Ile Asp Asn Arg Gln Cys 
             1620                1625                1630
Val Gln Asp Ser Asp His Cys Phe Lys Asn Thr Asp Ala Ala Ala Ala 
         1635                1640                1645
Leu Leu Ala Ser His Ala Ile Gln Gly Thr Leu Ser Tyr Pro Leu Val 
     1650                1655                1660
Ser Val Val Ser Glu Ser Leu Thr Pro Glu Arg Thr Gln Leu Leu Tyr 
 1665                1670                1675                1680
Leu Leu Ala Val Ala Val Val Ile Ile Leu Phe Ile Ile Leu Leu Gly 
                 1685                1690                1695
Val Ile Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro 
             1700                1705                1710
Glu Gly Phe Thr Leu Arg Arg Asp Ala Ser Asn His Lys Arg Arg Glu 
         1715                1720                1725
Pro Val Gly Gln Asp Ala Val Gly Leu Lys Asn Leu Ser Val Gln Val 
     1730                1735                1740
Ser Glu Ala Asn Leu Ile Gly Thr Gly Thr Ser Glu His Trp Val Asp 
 1745                1750                1755                1760
Asp Glu Gly Pro Gln Pro Lys Lys Val Lys Ala Glu Asp Glu Ala Leu 
                 1765                1770                1775
Leu Ser Glu Glu Asp Asp Pro Ile Asp Arg Arg Pro Trp Thr Gln Gln 
             1780                1785                1790
His Leu Glu Ala Ala Asp Ile Arg Arg Thr Pro Ser Leu Ala Leu Thr 
         1795                1800                1805
Pro Pro Gln Ala Glu Gln Glu Val Asp Val Leu Asp Val Asn Val Arg 
     1810                1815                1820
Gly Pro Asp Gly Cys Thr Pro Leu Met Leu Ala Ser Leu Arg Gly Gly 
 1825                1830                1835                1840
Ser Ser Asp Leu Ser Asp Glu Asp Glu Asp Ala Glu Asp Ser Ser Ala 
                 1845                1850                1855
Asn Ile Ile Thr Asp Leu Val Tyr Gln Gly Ala Ser Leu Gln Ala Gln 
             1860                1865                1870
Thr Asp Arg Thr Gly Glu Met Ala Leu His Leu Ala Ala Arg Tyr Ser 
         1875                1880                1885
Arg Ala Asp Ala Ala Lys Arg Leu Leu Asp Ala Gly Ala Asp Ala Asn 
     1890                1895                1900
Ala Gln Asp Asn Met Gly Arg Cys Pro Leu His Ala Ala Val Ala Ala 
 1905                1910                1915                1920
Asp Ala Gln Gly Val Phe Gln Ile Leu Ile Arg Asn Arg Val Thr Asp 
                 1925                1930                1935
Leu Asp Ala Arg Met Asn Asp Gly Thr Thr Pro Leu Ile Leu Ala Ala 
             1940                1945                1950
Arg Leu Ala Val Glu Gly Met Val Ala Glu Leu Ile Asn Cys Gln Ala 
         1955                1960                1965
Asp Val Asn Ala Val Asp Asp His Gly Lys Ser Ala Leu His Trp Ala 
     1970                1975                1980
Ala Ala Val Asn Asn Val Glu Ala Thr Leu Leu Leu Leu Lys Asn Gly 
 1985                1990                1995                2000
Ala Asn Arg Asp Met Gln Asp Asn Lys Glu Glu Thr Pro Leu Phe Leu 
                 2005                2010                2015
Ala Ala Arg Glu Gly Ser Tyr Glu Ala Ala Lys Ile Leu Leu Asp His 
             2020                2025                2030
Phe Ala Asn Arg Asp Ile Thr Asp His Met Asp Arg Leu Pro Arg Asp 
         2035                2040                2045
Val Ala Arg Asp Arg Met His His Asp Ile Val Arg Leu Leu Asp Glu 
     2050                2055                2060
Tyr Asn Val Thr Pro Ser Pro Pro Gly Thr Val Leu Thr Ser Ala Leu 
 2065                2070                2075                2080
Ser Pro Val Ile Cys Gly Pro Asn Arg Ser Phe Leu Ser Leu Lys His 
                 2085                2090                2095
Thr Pro Met Gly Lys Lys Ser Arg Arg Pro Ser Ala Lys Ser Thr Met 
             2100                2105                2110
Pro Thr Ser Leu Pro Asn Leu Ala Lys Glu Ala Lys Asp Ala Lys Gly 
         2115                2120                2125
Ser Arg Arg Lys Lys Ser Leu Ser Glu Lys Val Gln Leu Ser Glu Ser 
     2130                2135                2140
Ser Val Thr Leu Ser Pro Val Asp Ser Leu Glu Ser Pro His Thr Tyr 
 2145                2150                2155                2160
Val Ser Asp Thr Thr Ser Ser Pro Met Ile Thr Ser Pro Gly Ile Leu 
                 2165                2170                2175
Gln Ala Ser Pro Asn Pro Met Leu Ala Thr Ala Ala Pro Pro Ala Pro 
             2180                2185                2190
Val His Ala Gln His Ala Leu Ser Phe Ser Asn Leu His Glu Met Gln 
         2195                2200                2205
Pro Leu Ala His Gly Ala Ser Thr Val Leu Pro Ser Val Ser Gln Leu 
     2210                2215                2220
Leu Ser His His His Ile Val Ser Pro Gly Ser Gly Ser Ala Gly Ser 
 2225                2230                2235                2240
Leu Ser Arg Leu His Pro Val Pro Val Pro Ala Asp Trp Met Asn Arg 
                 2245                2250                2255
Met Glu Val Asn Glu Thr Gln Tyr Asn Glu Met Phe Gly Met Val Leu 
             2260                2265                2270
Ala Pro Ala Glu Gly Thr His Pro Gly Ile Ala Pro Gln Ser Arg Pro 
         2275                2280                2285
Pro Glu Gly Lys His Ile Thr Thr Pro Arg Glu Pro Leu Pro Pro Ile 
     2290                2295                2300
Val Thr Phe Gln Leu Ile Pro Lys Gly Ser Ile Ala Gln Pro Ala Gly 
 2305                2310                2315                2320
Ala Pro Gln Pro Gln Ser Thr Cys Pro Pro Ala Val Ala Gly Pro Leu 
                 2325                2330                2335
Pro Thr Met Tyr Gln Ile Pro Glu Met Ala Arg Leu Pro Ser Val Ala 
             2340                2345                2350
Phe Pro Thr Ala Met Met Pro Gln Gln Asp Gly Gln Val Ala Gln Thr 
         2355                2360                2365
Ile Leu Pro Ala Tyr His Pro Phe Pro Ala Ser Val Gly Lys Tyr Pro 
     2370                2375                2380
Thr Pro Pro Ser Gln His Ser Tyr Ala Ser Ser Asn Ala Ala Glu Arg 
 2385                2390                2395                2400
Thr Pro Ser His Ser Gly His Leu Gln Gly Glu His Pro Tyr Leu Thr 
                 2405                2410                2415
Pro Ser Pro Glu Ser Pro Asp Gln Trp Ser Ser Ser Ser Pro His Ser 
             2420                2425                2430
Ala Ser Asp Trp Ser Asp Val Thr Thr Ser Pro Thr Pro Gly Gly Ala 
         2435                2440                2445
Gly Gly Gly Gln Arg Gly Pro Gly Thr His Met Ser Glu Pro Pro His 
     2450                2455                2460
Asn Asn Met Gln Val Tyr Ala 
 2465                2470



<210> 9656
<211> 8221
<212> DNA
<213> Rattus norvegicus
<308> X57405
<400> 9656

ggcgggtca  ggagcgcag  ggcgtgggg  gcagggccg  gtgcagcgc  gtgaaggaa  60
gagcctggg  tgccctgta  tgccgggga  accctgaga  cccagcccg  ccacccgcc  120
ggaaagagg  cagcagcgg  tggaacgcc  gcgggaccg  ccgtggtgc  cgtgaacgt  180
cgatcccgg  cggccaccg  aagaggccg  cgcccggca  cgggcagct  gcgagcagg  240
atgccgcgg  tcctggcgc  cttgctctg  ctaacgctg  tgcccgcgc  cgccgcaag  300
ggcttgaga  gctcccagc  aagtgggac  tgcctgaat  gagggaggt  cgaagtggc  360
aacggcact  aagcctgtg  ctgcagcgg  gcgttcgtg  gccagcgat  ccaggaccc  420
agcccttgc  tcagcacac  atgtaagaa  gctggaacg  gctatgttg  ggaccatgg  480
ggcatcgtg  actatgcct  cagttgccc  ctgggtttc  ctgggcccc  ctgcctgac  540
cctctggcc  atgcctgcc  ggccaaccc  tgccgcaac  gggggacct  tgacctgct  600
actctcaca  aatacaagt  ccggtgccc  ccagggtgg  caggaaagt  atgtcagca  660
gccgacccc  gtgcctcca  cccctgtgc  aatggtggc  agtgcctgc  ctttgagtc  720
tcatacatc  gtggctgcc  gcccggctt  catggcccc  cctgcagac  agatgttaa  780
gagtgcagc  agaaccctg  gttgtgccg  catgggggc  cgtgccaca  tgagattgg  840
tcctatcgc  gtgcctgcc  tgccaccca  actggtccc  actgcgagc  gccctacgt  900
ccctgcagc  cctcaccct  ccagaacgg  ggcacctgc  gccctacgg  ggacaccac  960
cacgagtgt  cctgcctgc  aggctttgc  ggacagaac  gtgaagaaa  tgtggatga  1020
tgcccagga  acaactgca  gaacggggg  gcctgtgtg  acggtgtga  tacctacaa  1080
tgccgctgc  caccggagt  gacaggtca  tactgcaca  aggatgtgg  cgagtgtca  1140
ctcatgccc  acgcctgcc  gaatgcggg  acctgccac  actcccacg  tggctacaa  1200
tgcgtgtgt  tcaatggct  gactggtga  gactgcagt  acaacattg  tgactgtgc  1260
agtgccgcc  gttttcagg  tgccacctg  catgaccgt  tggcttcct  ctactgcga  1320
tgtccacat  ggcgcacag  cctgctgtg  cacctgaac  atgcgtgta  cagcaaccc  1380
tgcaacgag  gctccaact  cgacaccaa  cctgtcaac  gcaaggcca  ctgcacttg  1440
cctcggggg  acacggggc  agcctgcag  caggacgtg  atgagtgcg  tctaggtgc  1500
aacccgtgt  agcacgcgg  caagtgcct  aacacactg  gctctttcg  gtgtcagtg  1560
ctacagggc  acactgggc  ccgctgtga  attgatgtc  acgagtgca  ctccaaccc  1620
tgtcagaat  atgccacgt  cctggacca  attggggag  ttcagtgta  atgtatgcc  1680
ggttatgag  gtgtatact  tgagatcaa  acggacgag  gtgccagca  cccctgtct  1740
cacaatggc  gctgcgtgg  caagatcaa  gagttcctg  gtcagtgtc  caaaggctt  1800
agcgggcac  tgtgccagt  tgacgtgga  gagtgcgcc  gcacaccat  caagaacgg  1860
gccaagtgc  tggatgggc  caacaccta  acctgcgtg  gcacagaag  ttacacggg  1920
acccactgc  aggtggaca  tgacgagtg  gaccctgac  cctgtcaca  tggtttgtg  1980
aaggatggt  tggccacct  tacctgcct  tgccagcca  gctacacag  ccatcactg  2040
gagaccaac  ttaatgagt  tcacagcca  ccgtgccgc  atggcggca  ctgccagga  2100
cgtgacaac  actacctct  cttatgcct  aaggggacc  caggaccca  ctgtgagat  2160
aatctggat  actgtgcga  caacccctg  gactctggc  cgtgtctgg  caagatcga  2220
ggctacgag  gtgcgtgcg  gccaggcta  acagggagc  tgtgtaatg  caacattga  2280
gaatgtgcg  gcagcccct  ccacaacgg  ggcacctgt  aggatggca  cgccggctt  2340
acttgccgc  gccccgagg  ctaccacga  cctacgtgc  tgtctgagg  caacgagtg  2400
aacagtaac  cctgcatcc  tggagcttg  cgggatggc  tcaatggat  caaatgtga  2460
tgtgcccct  ggtggagtg  gacaaactg  gacatcaac  acaatgagt  tgagtccaa  2520
ccttgtgtc  acggtggca  ctgcaaaga  atgaccagt  gctacgtat  cacctgccg  2580
gaaggcttc  gtggcccta  ctgccagac  aacattaac  aatgtgctt  caacccctg  2640
ctgaaccag  gcacctgca  tgatgatgt  gctgggtac  aatgcaact  ccctctgcc  2700
tatacagga  ccacatgtg  ggtggtgtt  gccccatgt  ccaccagcc  ctgcaaaaa  2760
agtggggta  gcaaggagt  tgaggacta  gagagcttt  cctgtgtct  tcccacagg  2820
tggcaaggt  aaacctgcg  gatcgacat  aatgagtgt  tgaaaagcc  gtgtcgcca  2880
ggtgcctct  gccagaaca  caatggcag  taccgctgc  tctgccagg  tggctacac  2940
ggtcgcaac  gcgagagtg  catcgatga  tgccgaccc  acccatgtc  caacggggg  3000
tcctgcact  acggggtca  cgcggcctt  tgcgactgc  tgcccggct  ccagggtgc  3060
ttctgtgag  aggacatca  cgaatgcgc  acgaatcca  gccaaaatg  cgccaactg  3120
actgactgc  tggacagct  cacgtgcac  tgccccacc  ggttcaatg  catccattg  3180
gagaacaac  cacctgact  taccgagag  tcctgtttc  atggtggca  ctgtgtgga  3240
ggtatcaac  ccttcacct  tctgtgccc  cctggcttc  cgggcagct  ctgccagta  3300
gacgtcaat  agtgtgact  acggccctg  ctgcatggt  gcacctgcc  agacagcta  3360
ggtacctat  agtgtacct  cccacaggg  tacactggt  tcaactgcc  gaaccttgt  3420
cgctggtgt  actcagctc  ctgcaagaa  ggcggcaag  gctggcaga  caacacaca  3480
taccactgc  agtgccgca  cggctggac  ggcttcaac  gcgacgtgc  cagtgtgtc  3540
tgcgaggtg  ctgcacaga  gcgaggcat  gatgtcact  tcctatgcc  gcacggagg  3600
ctctgtgtg  atgaggaag  caagcatta  tgccactgc  aggcaggat  cacgggcag  3660
tactgtgag  acgaggtgg  cgagtgctc  cctaatccc  gccagaacg  agccacctg  3720
actgactat  tcggtggct  ttcctgcaa  tgtgtggct  ggtaccatg  ctctaactg  3780
tctgaggag  tcaacgagt  cctatccca  ccctgccag  atgggggta  ctgcattga  3840
ctgaccaac  cctacaagt  ctcctgccc  aggggcaca  agggtgtac  ctgtgagat  3900
aacgtcgat  actgccatc  tcccctaga  cctgcttcc  gaagcccca  atgcttcaa  3960
aatggcacc  gcgtggacc  ggtgggtgg  tatacctgc  cctgcccgc  aggcttcgt  4020
ggggagcgg  gcgagggcg  tgtcaatga  tgtctctcc  acccctgtg  cccacgtgg  4080
acccagaac  gcgtgcagc  tgttaatga  ttccactgc  agtgccggg  tggccacac  4140
ggacgccgc  gtgagtcgg  cattaatgg  tgcaggggc  aaccatgca  gaatggagg  4200
gtctgtgct  tggcctcca  caccgcccg  ggattcatc  gtaggtgcc  tgcccgctt  4260
gagggtgcc  cttgtgaaa  tgacgcccg  acttgtggc  gtttgcgct  cctcaacgg  4320
ggtacgtgc  tctcaggcc  acgcagtcc  acctgccta  gcctgggct  cttcactgg  4380
cctgaatgc  agttcccag  cagcagccc  tgtgtgggt  gcaacccct  ctacaatca  4440
ggcacctgt  agcccacat  cgagagccc  ttctaccgc  gtctatgcc  tgccaaatt  4500
aacgggctg  tgtgccaca  cctggacta  agcttcaca  gtgcggccg  gcgcgacat  4560
cccccgcca  agattgagg  ggcctgcga  ctgcctgag  gccaggagg  tgcaggcaa  4620
aaggtctgc  accttcagt  taataatca  gcgtgtggc  gggacggcg  cgactgctc  4680
ctcaacttc  atgaccctt  gaagaactg  actcagtcc  tgcagtgct  gaagtattt  4740
agtgacggc  actgtgaca  ccagtgcaa  tcagctggc  gcctttttg  tggcttcga  4800
tgccagctc  ccgagggac  gtgcaaccc  ctgtatgac  agtactgca  ggaccactt  4860
agtgatggc  actgcgacc  gggctgcaa  agtgccgag  gtgagtggg  tggactgga  4920
tgtgcagag  atgtccccg  gcgactggc  gccggcaca  tggtgctgg  ggtgctgct  4980
ccgcccgat  agctacgca  caactcctt  cacttcctg  gggacgtca  ccacgtgct  5040
cacaccaac  tggtcttca  gcgtgacgc  cagggccag  agatgatct  cccctacta  5100
ggccgcgag  aagagctac  caagcaccc  atcaagcgt  ctgcagtgg  ctgggccac  5160
acgtcactg  ttcctggca  caatggtgg  cgccagcgc  gggagctgg  ccccatgga  5220
atccatggc  ccatcgtct  cctggagat  gacaaccgg  agtgtgtac  gtcatcctc  5280
caatgcttc  agagcgcca  cgatgtggc  gccttccta  gtgctcttg  ctccctcgg  5340
agcctcaat  tcccctaca  gatcgaagc  gtaaagagt  agacggtgg  gcctccgct  5400
ccctcacag  tgcacctca  gtacgtggc  gcagctgcc  tcgtgctcc  gttctttgt  5460
ggctgtggg  tgctgctgt  ccgcaagcg  aggcggcag  atggccagc  ctggttccc  5520
gagggtttc  aagtgtcag  ggccagcaa  aagaagcgg  gagaacccc  cggcgagga  5580
tcagtcggc  tcaagcccc  gaagaacgc  tcagatggt  ccctgatgg  cgacaatca  5640
aacgagtgg  gggacgaag  cctggagac  aagaagttc  ggtttgagg  accagtggt  5700
ctccctgac  tggatgatc  gactgacca  cggcagtgg  cccagcagc  cctggatgc  5760
gctgaccta  gtgtgtctg  catggcccc  acgccgcct  agggggagg  agatgctga  5820
tgcatggac  tcaatgttc  aggaccaga  ggcttcact  ccctaatga  tgcctcctg  5880
agcggaggg  gcctggaga  aggcaacag  gaggaagaa  aagatgcac  tgctgtcat  5940
tccgacttc  tctatcagg  tgccagctt  cacaaccag  cggaccgca  aggggagac  6000
gccctgcac  tggctgccc  atactctcg  tcagatgct  ccaagcgct  gctggaggc  6060
agcgcagat  ccaacatcc  agacaacat  gggcgtacc  cattacatg  cgctgtttc  6120
gcagacgct  agggtgtct  ccagatcct  ctccggaac  gagccacag  tctggatgc  6180
cgaatgcat  atggcacaa  ccctctgat  ctggcggca  gcctggccg  ggaaggcat  6240
ctagaggac  tcatcaact  tcacgctga  gtcaatgct  tggatgacc  aggcaagtc  6300
gctctgcac  gggcagccg  tgtgaacaa  gtggacgct  ctgttgtgc  cctgaagaa  6360
ggagccaac  aagacatgc  gaacaacaa  gaggagact  ccctgttcc  ggccgcccg  6420
gagggcagc  atgagactg  caaagtgtt  ctggaccac  ttgccaacc  ggacatcac  6480
gatcacatg  accgattgc  acgggacat  gcacaggag  gcatgcacc  cgatatcgt  6540
cggcttttg  atgaataca  cctggtgcg  agcccacag  tgcatggca  tgccttggg  6600
ggcacaccc  ctctgtctc  cacactctg  tcgcccaac  gctacctgg  caacctcaa  6660
tctgccaca  agggcaaga  ggcccgaaa  cccagcacc  aagggctgg  ttgcagtag  6720
aaggaagct  aggacctca  ggcccggag  aagaagtcc  aggatggca  gggctgcct  6780
ttggacagc  caagcatgc  gtcacccgt  gactccctc  agtcacccc  tggctactt  6840
tcagatgtg  cctcaccac  cctccttcc  tccccgttc  agcagtctc  atccatgcc  6900
ctcagccac  tgccaggta  gcctgacac  cacctgggc  tcagccact  gaatgtggc  6960
gccaagccc  agatggcag  tctggccgg  ggcagccgg  tggcctttg  gccaccccc  7020
ccacgcctc  cccacctgc  tgtagcctc  agtgccagc  cagtgctga  taccaatgg  7080
acaggggct  tgaatttca  cgtgggtgc  ccggcaagc  tgaatggcc  gtgtgagtg  7140
cttccccgg  tccagaatg  catggtgcc  agccagtac  acccgctaa  gccaggtgt  7200
actccgggc  cactaagca  acaggcagc  ggcctccag  atggcatga  gggcccgat  7260
cacagcagc  tctccacca  taccttgtc  ccgattatc  accagggcc  gcccaacac  7320
aggctggcc  cacagcccc  cctggtgca  acccagcag  tgcagccac  gaacttaca  7380
atccagcct  agaacctgc  gccaccatc  cagccacac  tcagtgtga  ctcagcagc  7440
aatgggcac  tgggtcgga  cttcctgag  ggggagccc  gccaggcag  cgtacagcc  7500
ctgggcccc  gcagtctgc  tgtgcacac  attctgccc  aggaaagcc  ggctctgcc  7560
acatcactg  catcctcca  ggtcccacc  atgaccact  cccagttcc  gacccctcc  7620
tctcagcac  gctactcat  ctcacctgt  gacaacacc  ccagccacc  gctgcaggt  7680
ccagagcac  ccttcctca  cccatcccc  gagtcccct  accagtggt  cagctcctc  7740
cggcattcc  acatctctg  ttggtccga  ggcatctct  gcccgccca  gagcatgcc  7800
tcccagatc  cccacattc  agaggcatt  aagtaaaca  agatgtggg  tgaaggacc  7860
cagcttccg  tcccaagct  tgttgggag  cctttccag  gctccagga  gctggggcg  7920
ccaaaggag  cttttaaaa  aaaatgttt  tatacaaaa  aagaggaca  gaatttcca  7980
ttttttttt  gtatttatt  atgtacttt  attttccac  gaaacactg  ctttttatt  8040
atatgtatt  ttttctatg  cactagggg  aaacatctg  tccaagaaa  taaactagt  8100
ctgagagcc  cgattttcc  ggtcagggt  aagttccct  tgtgtttgt  aaatacgaa  8160
aaggattca  gatttgtaa  tgccgttta  ttattgatt  cttctttcc  aaatcgtcg  8220
g  8221



<210> 9657
<211> 2531
<212> PRT
<213> Rattus norvegicus
<308> CAA40667
<400> 9657

Met Pro Arg Leu Leu Ala Pro Leu Leu Cys Leu Thr Leu Leu Pro Ala 
  1               5                  10                  15
Leu Ala Ala Arg Gly Leu Arg Cys Ser Gln Pro Ser Gly Thr Cys Leu 
             20                  25                  30
Asn Gly Gly Arg Cys Glu Val Ala Asn Gly Thr Glu Ala Cys Val Cys 
         35                  40                  45
Ser Gly Ala Phe Val Gly Gln Arg Cys Gln Asp Pro Ser Pro Cys Leu 
     50                  55                  60
Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys Tyr Val Val Asp His Gly 
 65                  70                  75                  80
Gly Ile Val Asp Tyr Ala Cys Ser Cys Pro Leu Gly Phe Ser Gly Pro 
                 85                  90                  95
Leu Cys Leu Thr Pro Leu Ala Asn Ala Cys Leu Ala Asn Pro Cys Arg 
             100                105                110
Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
         115                120                125
Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
     130                135                140
Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ser 
 145                150                155                160
Ser Tyr Ile Cys Gly Cys Pro Pro Gly Phe His Gly Pro Thr Cys Arg 
                 165                170                175
Gln Asp Val Asn Glu Cys Ser Gln Asn Pro Gly Leu Cys Arg His Gly 
             180                185                190
Gly Thr Cys His Asn Glu Ile Gly Ser Tyr Arg Cys Ala Cys Arg Ala 
         195                200                205
Thr His Thr Gly Pro His Cys Glu Leu Pro Tyr Val Pro Cys Ser Pro 
     210                215                220
Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Thr Thr 
 225                230                235                240
His Glu Cys Ala Cys Leu Pro Gly Phe Ala Gly Gln Asn Cys Glu Glu 
                 245                250                255
Asn Val Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
             260                265                270
Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
         275                280                285
Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
     290                295                300
Ala Cys Gln Asn Ala Gly Thr Cys His Asn Ser His Gly Gly Tyr Asn 
 305                310                315                320
Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Asp Asn Ile 
                 325                330                335
Asp Asp Cys Ala Ser Ala Ala Cys Phe Gln Gly Ala Thr Cys His Asp 
             340                345                350
Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
         355                360                365
Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
     370                375                380
Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
 385                390                395                400
Pro Arg Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                 405                410                415
Ala Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Leu Asn Thr 
             420                425                430
Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
         435                440                445
Cys Glu Ile Asp Val Asn Glu Cys Ile Ser Asn Pro Cys Gln Asn Asp 
     450                455                460
Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
 465                470                475                480
Gly Tyr Glu Gly Val Tyr Cys Glu Ile Asn Thr Asp Glu Cys Ala Ser 
                 485                490                495
Ser Pro Cys Leu His Asn Gly Arg Cys Val Asp Lys Ile Asn Glu Phe 
             500                505                510
Leu Cys Gln Cys Pro Lys Gly Phe Ser Gly His Leu Cys Gln Tyr Asp 
         515                520                525
Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
     530                535                540
Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
 545                550                555                560
Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                 565                570                575
Ile Gly Leu Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Gln 
             580                585                590
Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys His 
         595                600                605
Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Tyr 
     610                615                620
Tyr Leu Cys Leu Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
 625                630                635                640
Asn Leu Asp Asp Cys Ala Ser Asn Pro Cys Asp Ser Gly Thr Cys Leu 
                 645                650                655
Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
             660                665                670
Ser Met Cys Asn Val Asn Ile Asp Glu Cys Ala Gly Ser Pro Cys His 
         675                680                685
Asn Gly Gly Thr Cys Glu Asp Gly Ile Ala Gly Phe Thr Cys Arg Cys 
     690                695                700
Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
 705                710                715                720
Asn Ser Asn Pro Cys Ile His Gly Ala Cys Arg Asp Gly Leu Asn Gly 
                 725                730                735
Tyr Lys Cys Asp Cys Ala Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
             740                745                750
Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
         755                760                765
Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
     770                775                780
Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
 785                790                795                800
Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                 805                810                815
Cys Pro Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
             820                825                830
Cys Ala Thr Ser Pro Cys Lys Asn Ser Gly Val Cys Lys Glu Ser Glu 
         835                840                845
Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
     850                855                860
Thr Cys Glu Ile Asp Ile Asn Glu Cys Val Lys Ser Pro Cys Arg His 
 865                870                875                880
Gly Ala Ser Cys Gln Asn Thr Asn Gly Ser Tyr Arg Cys Leu Cys Gln 
                 885                890                895
Ala Gly Tyr Thr Gly Arg Asn Cys Glu Ser Asp Ile Asp Asp Cys Arg 
             900                905                910
Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Val Asn Ala 
         915                920                925
Ala Phe Cys Asp Cys Leu Pro Gly Phe Gln Gly Ala Phe Cys Glu Glu 
     930                935                940
Asp Ile Asn Glu Cys Ala Thr Asn Pro Cys Gln Asn Gly Ala Asn Cys 
 945                950                955                960
Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Thr Gly Phe Asn 
                 965                970                975
Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
             980                985                990
Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser Phe Thr Cys Leu 
         995                1000                1005
Cys Pro Pro Gly Phe Thr Gly Ser Tyr Cys Gln Tyr Asp Val Asn Glu 
     1010                1015                1020
Cys Asp Ser Arg Pro Cys Leu His Gly Gly Thr Cys Gln Asp Ser Tyr 
 1025                1030                1035                1040
Gly Thr Tyr Lys Cys Thr Cys Pro Gln Gly Tyr Thr Gly Leu Asn Cys 
                 1045                1050                1055
Gln Asn Leu Val Arg Trp Cys Asp Ser Ala Pro Cys Lys Asn Gly Gly 
             1060                1065                1070
Lys Cys Trp Gln Thr Asn Thr Gln Tyr His Cys Glu Cys Arg Ser Gly 
         1075                1080                1085
Trp Thr Gly Phe Asn Cys Asp Val Leu Ser Val Ser Cys Glu Val Ala 
     1090                1095                1100
Ala Gln Lys Arg Gly Ile Asp Val Thr Leu Leu Cys Gln His Gly Gly 
 1105                1110                1115                1120
Leu Cys Val Asp Glu Glu Asp Lys His Tyr Cys His Cys Gln Ala Gly 
                 1125                1130                1135
Tyr Thr Gly Ser Tyr Cys Glu Asp Glu Val Asp Glu Cys Ser Pro Asn 
             1140                1145                1150
Pro Cys Gln Asn Gly Ala Thr Cys Thr Asp Tyr Leu Gly Gly Phe Ser 
         1155                1160                1165
Cys Lys Cys Val Ala Gly Tyr His Gly Ser Asn Cys Ser Glu Glu Ile 
     1170                1175                1180
Asn Glu Cys Leu Ser Gln Pro Cys Gln Asn Gly Gly Thr Cys Ile Asp 
 1185                1190                1195                1200
Leu Thr Asn Thr Tyr Lys Cys Ser Cys Pro Arg Gly Thr Gln Gly Val 
                 1205                1210                1215
His Cys Glu Ile Asn Val Asp Asp Cys His Pro Pro Leu Asp Pro Ala 
             1220                1225                1230
Ser Arg Ser Pro Lys Cys Phe Asn Asn Gly Thr Cys Val Asp Gln Val 
         1235                1240                1245
Gly Gly Tyr Thr Cys Thr Cys Pro Pro Gly Phe Val Gly Glu Arg Cys 
     1250                1255                1260
Glu Gly Asp Val Asn Glu Cys Leu Ser Asn Pro Cys Asp Pro Arg Gly 
 1265                1270                1275                1280
Thr Gln Asn Cys Val Gln Arg Val Asn Asp Phe His Cys Glu Cys Arg 
                 1285                1290                1295
Ala Gly His Thr Gly Arg Arg Cys Glu Ser Val Ile Asn Gly Cys Arg 
             1300                1305                1310
Gly Lys Pro Cys Arg Asn Gly Gly Val Cys Ala Val Ala Ser Asn Thr 
         1315                1320                1325
Ala Arg Gly Phe Ile Cys Arg Cys Pro Ala Arg Phe Glu Gly Ala Thr 
     1330                1335                1340
Cys Glu Asn Asp Ala Arg Thr Cys Gly Ser Leu Arg Cys Leu Asn Gly 
 1345                1350                1355                1360
Gly Thr Cys Ile Ser Gly Pro Arg Ser Pro Thr Cys Leu Cys Leu Gly 
                 1365                1370                1375
Ser Phe Thr Gly Pro Glu Cys Gln Phe Pro Ala Ser Ser Pro Cys Val 
             1380                1385                1390
Gly Ser Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro Thr Ser Glu 
         1395                1400                1405
Ser Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn Gly Leu Leu 
     1410                1415                1420
Cys His Ile Leu Asp Tyr Ser Phe Thr Gly Ala Ala Gly Arg Asp Ile 
 1425                1430                1435                1440
Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Glu 
                 1445                1450                1455
Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys 
             1460                1465                1470
Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys 
         1475                1480                1485
Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His 
     1490                1495                1500
Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp 
 1505                1510                1515                1520
Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys 
                 1525                1530                1535
Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala 
             1540                1545                1550
Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg 
         1555                1560                1565
Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln 
     1570                1575                1580
Leu Arg Asn Asn Ser Phe His Phe Leu Arg Asp Val Ser His Val Leu 
 1585                1590                1595                1600
His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile 
                 1605                1610                1615
Phe Pro Tyr Tyr Gly Arg Glu Glu Glu Leu Arg Lys His Pro Ile Lys 
             1620                1625                1630
Arg Ser Ala Val Gly Trp Ala Thr Thr Ser Leu Leu Pro Gly Thr Asn 
         1635                1640                1645
Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile His Gly Ser 
     1650                1655                1660
Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser 
 1665                1670                1675                1680
Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu 
                 1685                1690                1695
Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys 
             1700                1705                1710
Ser Glu Thr Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr 
         1715                1720                1725
Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val 
     1730                1735                1740
Leu Leu Ser Arg Lys Arg Arg Arg Gln His Gly Gln Leu Trp Phe Pro 
 1745                1750                1755                1760
Glu Gly Phe Lys Val Ser Glu Ala Ser Lys Lys Lys Arg Arg Glu Pro 
                 1765                1770                1775
Leu Gly Glu Asp Ser Val Gly Leu Lys Pro Leu Lys Asn Ala Ser Asp 
             1780                1785                1790
Gly Ala Leu Met Asp Asp Asn Gln Asn Glu Trp Gly Asp Glu Asp Leu 
         1795                1800                1805
Glu Thr Lys Lys Phe Arg Phe Glu Glu Pro Val Val Leu Pro Asp Leu 
     1810                1815                1820
Asp Asp Gln Thr Asp His Arg Gln Trp Thr Gln Gln His Leu Asp Ala 
 1825                1830                1835                1840
Ala Asp Leu Arg Val Ser Ala Met Ala Pro Thr Pro Pro Gln Gly Glu 
                 1845                1850                1855
Val Asp Ala Asp Cys Met Asp Val Asn Val Arg Gly Pro Asp Gly Phe 
             1860                1865                1870
Thr Pro Leu Met Ile Ala Ser Cys Ser Gly Gly Gly Leu Glu Thr Gly 
         1875                1880                1885
Asn Ser Glu Glu Glu Glu Asp Ala Pro Ala Val Ile Ser Asp Phe Ile 
     1890                1895                1900
Tyr Gln Gly Ala Ser Leu His Asn Gln Thr Asp Arg Thr Gly Glu Thr 
 1905                1910                1915                1920
Ala Leu His Leu Ala Ala Arg Tyr Ser Arg Ser Asp Ala Ala Lys Arg 
                 1925                1930                1935
Leu Leu Glu Ala Ser Ala Asp Ala Asn Ile Gln Asp Asn Met Gly Arg 
             1940                1945                1950
Thr Pro Leu His Ala Ala Val Ser Ala Asp Ala Gln Gly Val Phe Gln 
         1955                1960                1965
Ile Leu Leu Arg Asn Arg Ala Thr Asp Leu Asp Ala Arg Met His Asp 
     1970                1975                1980
Gly Thr Thr Pro Leu Ile Leu Ala Ala Arg Leu Ala Val Glu Gly Met 
 1985                1990                1995                2000
Leu Glu Asp Leu Ile Asn Ser His Ala Asp Val Asn Ala Val Asp Asp 
                 2005                2010                2015
Leu Gly Lys Ser Ala Leu His Trp Ala Ala Ala Val Asn Asn Val Asp 
             2020                2025                2030
Ala Ala Val Val Leu Leu Lys Asn Gly Ala Asn Lys Asp Met Gln Asn 
         2035                2040                2045
Asn Lys Glu Glu Thr Pro Leu Phe Leu Ala Ala Arg Glu Gly Ser Tyr 
     2050                2055                2060
Glu Thr Ala Lys Val Leu Leu Asp His Phe Ala Asn Arg Asp Ile Thr 
 2065                2070                2075                2080
Asp His Met Asp Arg Leu Pro Arg Asp Ile Ala Gln Glu Arg Met His 
                 2085                2090                2095
His Asp Ile Val Arg Leu Leu Asp Glu Tyr Asn Leu Val Arg Ser Pro 
             2100                2105                2110
Gln Leu His Gly Thr Ala Leu Gly Gly Thr Pro Thr Leu Ser Pro Thr 
         2115                2120                2125
Leu Cys Ser Pro Asn Gly Tyr Leu Gly Asn Leu Lys Ser Ala Thr Gln 
     2130                2135                2140
Gly Lys Lys Ala Arg Lys Pro Ser Thr Lys Gly Leu Ala Cys Ser Ser 
 2145                2150                2155                2160
Lys Glu Ala Lys Asp Leu Lys Ala Arg Arg Lys Lys Ser Gln Asp Gly 
                 2165                2170                2175
Lys Gly Cys Leu Leu Asp Ser Ser Ser Met Leu Ser Pro Val Asp Ser 
             2180                2185                2190
Leu Glu Ser Pro His Gly Tyr Leu Ser Asp Val Ala Ser Pro Pro Leu 
         2195                2200                2205
Leu Pro Ser Pro Phe Gln Gln Ser Pro Ser Met Pro Leu Ser His Leu 
     2210                2215                2220
Pro Gly Met Pro Asp Thr His Leu Gly Ile Ser His Leu Asn Val Ala 
 2225                2230                2235                2240
Ala Lys Pro Glu Met Ala Ala Leu Ala Gly Gly Ser Arg Leu Ala Phe 
                 2245                2250                2255
Glu Pro Pro Pro Pro Arg Leu Ser His Leu Pro Val Ala Ser Ser Ala 
             2260                2265                2270
Ser Thr Val Leu Ser Thr Asn Gly Thr Gly Ala Met Asn Phe Thr Val 
         2275                2280                2285
Gly Ala Pro Ala Ser Leu Asn Gly Gln Cys Glu Trp Leu Pro Arg Leu 
     2290                2295                2300
Gln Asn Gly Met Val Pro Ser Gln Tyr Asn Pro Leu Arg Pro Gly Val 
 2305                2310                2315                2320
Thr Pro Gly Thr Leu Ser Thr Gln Ala Ala Gly Leu Gln His Gly Met 
                 2325                2330                2335
Met Gly Pro Ile His Ser Ser Leu Ser Thr Asn Thr Leu Ser Pro Ile 
             2340                2345                2350
Ile Tyr Gln Gly Leu Pro Asn Thr Arg Leu Ala Thr Gln Pro His Leu 
         2355                2360                2365
Val Gln Thr Gln Gln Val Gln Pro Gln Asn Leu Gln Ile Gln Pro Gln 
     2370                2375                2380
Asn Leu Gln Pro Pro Ser Gln Pro His Leu Ser Val Ser Ser Ala Ala 
 2385                2390                2395                2400
Asn Gly His Leu Gly Arg Ser Phe Leu Ser Gly Glu Pro Ser Gln Ala 
                 2405                2410                2415
Asp Val Gln Pro Leu Gly Pro Ser Ser Leu Pro Val His Thr Ile Leu 
             2420                2425                2430
Pro Gln Glu Ser Gln Ala Leu Pro Thr Ser Leu Pro Ser Ser Met Val 
         2435                2440                2445
Pro Pro Met Thr Thr Thr Gln Phe Leu Thr Pro Pro Ser Gln His Ser 
     2450                2455                2460
Tyr Ser Ser Ser Pro Val Asp Asn Thr Pro Ser His Gln Leu Gln Val 
 2465                2470                2475                2480
Pro Glu His Pro Phe Leu Thr Pro Ser Pro Glu Ser Pro Asp Gln Trp 
                 2485                2490                2495
Ser Ser Ser Ser Arg His Ser Asn Ile Ser Asp Trp Ser Glu Gly Ile 
             2500                2505                2510
Ser Ser Pro Pro Thr Ser Met Pro Ser Gln Ile Thr His Ile Pro Glu 
         2515                2520                2525
Ala Phe Lys 
     2530



<210> 9658
<211> 11395
<212> DNA
<213> Homo sapiens
<308> XM_034671
<400> 9658

tttcagcca  acttcgggc  gcggctgag  cggcggccg  ggagcggcg  actcggggc  60
cggggagtc  aggcatttg  gcctgggct  cggagcgta  cgccagggc  tgagccttt  120
aagcaggag  aggggagga  agagtgggg  tcctctatc  ggaccccct  cccatgtgg  180
tctgcccag  cggcggcgg  ggcggcgga  gaggaggcg  ccgagaaga  gcccgccct  240
cgccccgct  tgctgtggg  gctgctggc  ctctggctg  gctgcgcgg  ccccgcgca  300
gcattgcag  gtcgagatg  ctatgaacc  tgtgtaaat  aaggaatgt  tgttaccta  360
cacaatggc  caggatact  caaatgtcc  gaaggcttc  tgggggaat  ttgtcaaca  420
cgagacccc  gtgagaaga  ccgctgcca  aatggtggg  cttgtgtgg  ccaggccat  480
ctggggaaa  ccacgtgcc  atgtgcctc  gggtttaca  gagaggact  ccagtactc  540
acatctcat  catgctttg  gtctcgacc  tgcctgaat  gcggcacat  ccatatgct  600
agccgggat  cctatgagt  cacctgtca  gtcgggttt  caggtaagg  gtgccaatg  660
acggatgcc  gcctgtctc  tccctgtgc  aatggaagt  cctgtacca  tgtggccaa  720
cagttctcc  gcaaatgcc  cacaggctt  acagggcag  aatgtgaga  tgatgtcaa  780
gagtgtgac  ttccaggac  ctgccagca  ggtggcacc  gcctcaacc  gcctggttc  840
taccagtgc  agtgccctc  gggcttcac  ggccagtac  gtgacagcc  gtatgtgcc  900
tgtgcaccc  caccttgtg  caatggagg  acctgtcgg  agactggtg  cttcacttt  960
gagtgcaac  gccttccag  ttttgaagg  agcacctgt  agaggaata  tgatgactg  1020
cctaaccac  ggtgtcaga  tggaggggt  tgtgtggat  gggtcaaca  ttacaactg  1080
cgctgtccc  cacaatgga  aggacagtt  tgcacagag  atgtggatg  atgcctgct  1140
cagcccaat  cctgtcaaa  tgggggcac  tgtgccaac  gcaatggag  ctatggctg  1200
gtatgtgtc  acggctgga  tggagatga  tgcagtgag  acattgatg  ttgtgcctt  1260
gcctcctgt  ctccaggct  cacctgcat  gaccgtgtg  cctccttct  ttgcatgtg  1320
ccagagggg  aggcaggtc  cctgtgtca  ctggatgat  catgcatca  caatccttg  1380
cacaagggg  cactgtgtg  caccaaccc  ctaaatggg  aatatattt  cacctgccc  1440
caaggctac  aaggggctg  ctgcacaga  gatgtggat  aatgtgcca  ggccaatag  1500
aatccttgt  agcatgcag  aaaatgtgt  aacacggat  gcgccttcc  ctgtgagtg  1560
ctgaagggt  atgcaggac  tcgttgtga  atggacatc  atgagtgcc  ttcagaccc  1620
tgccagaat  atgctacct  tctggataa  attggaggc  tcacatgtc  gtgcatgcc  1680
ggtttcaaa  gtgtgcatt  tgaattaga  ataaatgaa  gtcagagca  cccttgtgt  1740
aacaatggg  agtgtgtgg  taaagtcaa  cgtttccag  gcctgtgtc  tcctggttt  1800
actgggcca  tttgccaga  tgatattga  gactgttcc  gtactccgt  tctgaatgg  1860
gcaaagtgt  tcgatcacc  gaatggcta  gaatgccag  gtgccacag  tttcactgg  1920
gtgttgtgt  aggagaaca  tgacaactg  gaccccgat  cttgccacc  tggtcagtg  1980
caggatggt  ttgattcct  cacctgcat  tgcaatccc  ggtacatgg  cgccatctg  2040
agtgaccag  ttgatgaat  ttacagcag  ccttgcctg  acgatggtc  ctgcattga  2100
ctggtcaat  gctaccagt  caactgcca  ccaggcacg  caggggtta  ttgtgaaat  2160
aattttgat  actgtgcaa  taacccttg  atccatgga  tctgtatgg  tggcattaa  2220
cgctacagt  gtgtctgct  accaggatt  acagggcag  gatgtaaca  tgacattga  2280
gagtgtgcc  ccaatccct  tcgcaaggg  gcaacatgt  tcaacggtg  gaatggttt  2340
cgctgtata  gccccgagg  accccatca  cccagctgc  actcacagg  gaacgaatg  2400
ctgagcaat  cctgcatcc  tggaaactg  actggaggt  tcagtggat  taagtgtct  2460
tgtgatgca  gctgggttg  catcaactg  gaagtggac  aaaatgaat  cctttcgaa  2520
ccatgccag  atggaggaa  ttgtgacaa  ctggtgaat  gatacaggt  tacttgcaa  2580
aagggcttt  aaggctata  ctgccaggt  aatattgat  aatgtgcct  aaatccatg  2640
ctgaaccaa  gaacctgct  tgatgacat  agtggctac  cttgccact  tgtgctgcc  2700
tacacaggc  agaattgtc  gacagtatt  gctccctgt  ccccaaacc  ttgtgagaa  2760
gctgctgtt  gcaaagagt  accaaattt  gagagttat  cttgcttgt  tgctcctgg  2820
tggcaaggt  agcggtgta  cattgacat  gacgagtgt  tctccaagc  ctgcatgaa  2880
catggtctc  gccataaca  ccagggcag  tacatgtgt  aatgtccac  aggcttcag  2940
ggtatggac  gtgaggagg  cattgatga  tgccttgcc  atccttgcc  gaatggagg  3000
tcctgtatg  atggagtga  tactttctc  tgcctctgc  ttccgggtt  cactgggga  3060
aagtgccag  cagacatga  tgagtgtct  agtgaaccc  gtaagaatg  agggacctg  3120
tctgactac  tcaacagtt  cacttgcaa  tgccaggca  gatttgatg  agtccattg  3180
gagaacaac  tcaatgagt  cactgagag  tcctgtttc  atggtggca  atgtgttga  3240
gggattaac  ccttctctt  cttgtgccc  gtgggtttc  ctggatcct  ctgcctcca  3300
gagatcaat  aatgcagct  tcatccatg  ctgaatgag  gaacgtgtg  tgatggcct  3360
ggtacctac  gctgcagct  ccccctggg  tacactggg  aaaactgtc  gaccctggt  3420
aatctctgc  gtcggtctc  atgtaaaaa  aaaggtact  gcgttcaga  aaaagcaga  3480
tcccagtgc  tatgtccat  tggatgggc  ggtgcctat  gtgacgtgc  caatgtctc  3540
tgtgacata  cagcctcca  gagaggtgt  cttgttgaa  acttgtgcc  gcactcagg  3600
gtctgcatc  atgctggca  cacgcatta  tgtcagtgc  ccctgggct  tactgggag  3660
tactgtgag  agcaactcg  tgagtgtgc  tccaacccc  gccagcacg  ggcaacatg  3720
agtgacttc  ttggtggat  cagatgcga  tgtgtccca  gctatcagg  tgtcaactg  3780
gagtatgaa  tggatgagt  ccagaatca  ccctgccag  atggaggca  ctgtattga  3840
cttgtgaac  atttcaagt  ctcttgccc  ccaggcact  ggggcctac  ctgtgaaga  3900
aacattgat  actgtgccc  gggtcccca  tgccttaat  gtggtcagt  catggatag  3960
attggaggc  acagttgtc  ctgcttgcc  ggctttgct  gggagcgtt  tgagggaga  4020
atcaacgag  gcctctcca  cccctgcag  tctgagggc  gcctggact  tatacagct  4080
accaatgac  acctgtgtg  ttgccgtag  gcctttact  gccggcact  tgaaacctt  4140
gtcgatgtg  gtccccaga  gccctgcct  aatggaggg  cttgtgctg  ggccagtaa  4200
atgcctgat  gtttcattt  ccgttgtcc  ccgggattt  ccggggcaa  gtgccagag  4260
agctgtgga  aagtgaaat  taggaaggg  gagcagtgt  tgcacaccg  ctctggacc  4320
cgctgcttc  gccccagtc  ccgggactg  gagtcaggc  gtgccagta  cccctgcca  4380
cacgggggc  gctgccacc  tcagcgcca  cctccttat  actcctgcc  gtgtgcccc  4440
ccattctcg  gtagccgct  tgaactcta  acggcaccc  ccagcaccc  tcctgccac  4500
tgtctgagc  agtattgtg  cgacaaagc  cgggatggc  tctgtgatg  ggcctgcaa  4560
agccatgcc  gccagtggg  tgggggtga  tgttctctc  ccatggaga  cccctgggc  4620
aactgctcc  ccccacttc  ctgctggga  tatatcaac  accagtgtg  tgagctgtg  4680
aacacggtc  agtgcctgt  tgacaactt  gaatgccag  ggaacagca  gacatgcaa  4740
tatgacaaa  actgtgcag  ccacttcaa  gacaaccac  gtgaccagg  gtgcaacag  4800
gaggagtgt  gttgggatg  gctggactg  gctgctgac  aacctgaga  cctggcaga  4860
ggtaccctg  ttattgtgg  attgatgcc  cctgaacaa  tgctccagg  tgctcgcag  4920
ttcttgcgg  cactgggta  cctgctcca  accaacctg  gcattaagc  ggactccca  4980
ggggaactc  tggtgtacc  ctattatgg  gagaagtca  ctgctatga  gaaacagag  5040
atgacacgc  gatcccttc  tggtgaaca  gaacaggag  tggctggct  taaagtctt  5100
ctggaaatt  acaaccgcc  gtgtgttca  gactcagac  actgcttca  gaacacgga  5160
gcagcagca  ctctcctgg  ctctcacgc  atacagggg  ccctgtcat  ccctcttgt  5220
tctgtcgtc  gtgaatccc  gactccaga  cgcactcag  tcctctatc  ccttgctgt  5280
gctgttgtc  tcattctgt  tattattct  ctgggggta  tcatggcaa  acgaaagcg  5340
aagcatggc  ctctctggc  gcctgaagg  ttcactctt  gccgagatg  aagcaatca  5400
aagcgtcgt  agccagtgg  acaggatgc  gtggggctg  aaaatctct  agtgcaagt  5460
tcagaagct  acctaattg  tactggaac  agtgaacac  gggtcgatg  tgaagggcc  5520
cagccaaag  aagtaaagg  tgaagatga  gccttactc  cagaagaag  tgaccccat  5580
gatcgacgg  catggacac  gcagcacct  gaagctgca  acatccgta  gacaccatc  5640
ctggctctc  cccctcctc  ggcagagca  gaggtggat  tgttagatg  gaatgtccg  5700
ggcccagat  gctgcaccc  attgatgtt  gcttctctc  gaggaggca  ctcagattt  5760
agtgatgaa  atgaagatg  agaggactc  tctgctaac  tcatcacag  cttggtcta  5820
cagggtgcc  gcctccagg  ccagacaga  cggactggt  agatggccc  gcaccttgc  5880
gcccgctac  cacgggctg  tgctgccaa  cgtctcctg  atgcaggtg  agatgccaa  5940
gcccaggac  acatgggcc  ctgtccact  catgctgca  tggcagctg  tgcccaagg  6000
gtcttccag  ttctgattc  caaccgagt  actgatcta  atgccagga  gaatgatgg  6060
actacaccc  tgatcctgg  tgcccgcct  gctgtggag  gaatggtgg  agaactgat  6120
aactgccaa  cggatgtga  tgcagtgga  gaccatgga  aatctgctc  tcactgggc  6180
gctgctgtc  ataatgtgg  ggcaactct  ttgttgttg  aaaatgggg  caaccgaga  6240
atgcaggac  acaaggaag  gacacctct  tttcttgct  cccgggagg  gagctatga  6300
gcagccaag  tcctgttag  ccattttgc  aatcgagac  tcacagacc  tatggatcg  6360
cttccccgg  atgtggctc  ggatcgcat  caccatgac  ttgtgcgcc  tctggatga  6420
tacaatgtg  ccccaagcc  tccaggcac  gtgttgact  ctgctctct  acctgtcat  6480
tgtgggccc  acagatctt  cctcagcct  aagcacacc  caatgggca  gaagtctag  6540
cggcccagt  ccaagagta  catgcctac  agcctccct  accttgcca  ggaggcaaa  6600
gatgccaag  gtagtagga  gaagaagtc  ctgagtgag  aggtccaac  gtctgagag  6660
tcagtaact  tatcccctg  tgattccct  gaatctcct  acacgtatg  ttccgacac  6720
acatcctct  caatgatta  atcccctgg  atcttacag  cctcaccca  ccctatgtt  6780
gccactgcc  cccctcctg  cccagtcca  gcccagcat  cactatctt  ttctaacct  6840
catgaaatg  agcctttgg  acatggggc  agcactgtg  ttccctcag  gagccagtt  6900
ctatcccac  accacattg  gtctccagg  agtggcagt  ctggaagct  gagtaggct  6960
catccagtc  cagtcccag  agattggat  aaccgcatg  aggtgaatg  gacccagta  7020
aatgagatg  ttggtatgg  cctggctcc  gctgagggc  cccatcctg  catagctcc  7080
cagagcagg  cacctgaag  gaagcacat  accacccct  gggagccct  gccccccat  7140
gtgactttc  agctcatcc  taaaggcag  attgcccaa  cagcggggg  tccccagcc  7200
cagtccacc  gccctccag  tgttgcggg  cccctgccc  ccatgtacc  gattccaga  7260
atggcccgt  tgcccagtg  ggctttccc  actgccatg  tgccccagc  ggacgggca  7320
gtagctcag  ccattctcc  agcctatca  cctttccca  cctctgtgg  caagtaccc  7380
acaccccct  cacagcaca  ttatgcttc  tcaaatgct  ctgagcgaa  acccagtca  7440
agtggtcac  tccagggtg  gcatcccta  ctgacacca  ccccagagt  tcctgacca  7500
tggtcaagt  catcacccc  ctctgcttc  gactggtca  atgtgacca  cagccctac  7560
cctgggggt  ctggaggag  tcagcgggg  cctgggaca  acatgtctg  gccaccaca  7620
aacaacatg  aggtttatg  gtgagagag  ccacctcca  tgtagagac  taactgact  7680
ttgtaaatg  tgctgagga  caaatgaag  tcatccggg  gagaaatga  gaaatctct  7740
gagccagct  ctagaggta  gaaagagaa  atgttctta  tcagataat  caagagaag  7800
aattcgtca  tttcactgg  tatctgcaa  gcttattga  tattctaat  taataagac  7860
agtttgtgg  aatgcaaga  gaatacaag  cttgggtcc  tgtttactc  cttctattt  7920
gagaataag  tggatgctt  ttgaagccc  gacattctt  cagcttgga  tgcatttta  7980
gccctgcag  cttctgcca  atccatgag  agattctac  ctagcgtcc  gttgggaat  8040
atgccctgg  attctgcct  aattgacct  cgcatctcc  cctccttgg  cattctttt  8100
tcttcattt  gtgcttttg  ttttgcacc  ctccgtgat  gtagcccta  cagcatgtt  8160
tagggcaag  cctttgtgc  tttgatcat  ctggcccat  aaagcaact  tggtctcct  8220
tcccctcct  tcttcccgg  atcccttgg  gtctcacaa  gtttacttt  gtatggttc  8280
cagcacaaa  ctttcaagt  tgttgtttc  ttggaaaat  gacatactg  attgtgttc  8340
cctgcatat  tcattcctg  agagagaag  ggagaagaa  acttttctt  aacaaattt  8400
gggggcagg  gatcccttc  agaggctgc  ccttaattt  tcttgtctg  gtgcaggtc  8460
tcatataaa  tttaccagg  agaagggtg  gagtttgtt  tttttctgt  tatgggcct  8520
gtcagtgta  agttttatc  ttgatagtc  agttactat  accctcccc  cttttttaa  8580
accagaaaa  ggtttggaa  gttggaatg  ccaagagac  agttaactc  tgcaagagc  8640
agttaccca  ccacaggtc  ccctacttc  tgccaagca  tccattgac  gcctgtatg  8700
aacacattt  tcccagatc  gagcattct  ggcctgttt  actcactca  ccagcatat  8760
aaactagtc  taactgttg  gcctttcct  tcatatcca  agaagacac  gtctcaaat  8820
ttgtaccct  gccatttag  actgaactt  ccttagccc  agggaccca  tgacagttg  8880
cttccgttt  tcagatgat  agtctctac  gattatctt  ctgcttaaa  gcctgctca  8940
caatctttc  ttcacaccg  gtggtccgt  ttactggta  acccagtat  ttctcactg  9000
agacatgga  tttatatgt  caagtgcag  aattggaaa  ttggacttg  tttctatga  9060
ccaaaacag  cctataaga  ggttggaaa  ggaggaact  tatagcagc  tttgctatt  9120
tctgctacc  tttcttttc  tctgaagcg  ccatgacat  ccctttggc  actaacgta  9180
aaactcaac  gaacatttt  ctttcctag  gtcaccttt  agatgataa  ggacaacta  9240
agacttgct  attgttcag  ctgattgcc  ctcacctga  tccactctc  gtattcatg  9300
tcttggcaa  ttctttgac  ttcttttaa  ggcagaagc  ttttagtta  ttgtagata  9360
agaatagtt  tcttcctct  ctccttggg  cagttaata  ttggtccat  gctacactg  9420
aacttccgt  cagtgctgt  atgcccatg  cacctgcaa  ataagttct  cctgggcat  9480
ttgtagata  taacaggtg  attcccgac  cttttggtt  gaatgacag  tctcattcc  9540
tctatggct  caagtatgc  tcagtgctt  ccacttacc  gatttgtct  tcggtggcc  9600
catatggaa  ccctgcgtg  ctgttggca  aatagttta  aaatggttt  ttcagtcct  9660
tccaaattt  ttgaaccaa  aaaaataat  acttctgcc  tgagataag  agattaagt  9720
tgttcattc  ctgctttat  ctctccatg  ggcaacatt  tgtcagcct  tttcatagt  9780
tgcaaacat  ttatcattc  aaatggtga  tctctgccc  tggacccat  tattattca  9840
agatgggga  aacctatct  catggacct  tgtggacca  agcgtacct  cccctttct  9900
ccctcctgc  ccagcccca  ttctgaaag  atcagctac  gatccagcc  ctggatatt  9960
tatatcctc  cttttcctt  agcacaatg  cagaccaaa  tgcttgttt  tttttcttg  10020
actacttta  tttggatcc  ttgggtttg  agaaaggga  tgtgaaagc  gtcattaca  10080
acaacaggt  tcagtgatg  ggaggacaa  actgccttt  aaacttttt  ctgatctct  10140
agattttaa  aactcttga  ttgtgtggt  tctaataaa  gggaaggta  gatggataa  10200
cactttctc  tttgggttc  gaattggag  ctcagtttt  atgagacac  tcttttatg  10260
catgtatag  tcctcccct  ctatttttg  tttattttt  ttgttataa  tgctttctt  10320
ctttgactc  tcttctgcc  gcctttggg  ataggtttt  ttgtttgtt  atttgcttc  10380
tctgttttg  tttaagcat  attttctta  gtgaggtgg  gaagggaaa  gtatgaggg  10440
aagagagtc  gagaattaa  atattttag  ataagcaat  ggctgtgat  ctcaaatcc  10500
ttgcatcct  ttattgaat  tgccaattt  taatttttg  ataataaag  accaaaggt  10560
taatgtttt  ttgagaggt  gtttaggga  tttggccct  accaataca  tgaatgtat  10620
atgactatt  gggaggaca  atttatgta  ccagaggcc  ccactaata  gtggtacta  10680
ggttacttc  ttgtgtaca  ttctcttaa  agtgatatt  tatctgttt  tatgagaaa  10740
ccagtaacc  ataaaatga  cgcatattc  tgactaaac  tagtaagga  aatgcacac  10800
ttgttttta  ttttccgtt  cattctaaa  gtagttaag  tgaaattta  atgaaagca  10860
ttttatcac  aaataaaaa  ggtttgcca  gctcagtgg  gttgtattt  ttattttcc  10920
atactgcat  catggcctg  cagtgttac  tcatgatgt  ataatttgc  gagagagca  10980
attttcttt  ctttctgaa  cccacaaag  ctagcacca  acttctttt  ttcttcctt  11040
aattagatc  taaataaat  atcctgggg  aaaagcatc  gtcaaatag  aaacatcac  11100
aaactgagc  ctcttctgt  cactagcca  agctggtga  aaacagatg  ttgctcagg  11160
acaaggtgc  ttccaatgg  aatgcgaag  agttgctat  gcaagaatt  ggaactggg  11220
tataagtca  aatattaat  atgctgtta  gtaaatgat  ggtttgtaa  attccttaa  11280
tgaaatttg  gtagaactt  atatacagg  ttataaaat  atattttgt  tataaattt  11340
ttataagtt  acattcata  atttattta  aaagtcagt  agatatttg  acatg  11395



<210> 9659
<211> 2471
<212> PRT
<213> Homo sapiens
<308> XP_034671
<400> 9659

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
  1               5                  10                  15
Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
             20                  25                  30
Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
         35                  40                  45
Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
     50                  55                  60
Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
 65                  70                  75                  80
Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                 85                  90                  95
Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
             100                105                110
Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
         115                120                125
Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
     130                135                140
Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
 145                150                155                160
Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                 165                170                175
Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
             180                185                190
Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
         195                200                205
Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
     210                215                220
Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
 225                230                235                240
Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                 245                250                255
Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
             260                265                270
Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
         275                280                285
Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
     290                295                300
Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
 305                310                315                320
Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                 325                330                335
Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
             340                345                350
Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
         355                360                365
Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
     370                375                380
His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
 385                390                395                400
Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                 405                410                415
Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
             420                425                430
Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
         435                440                445
Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
     450                455                460
Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
 465                470                475                480
Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                 485                490                495
Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
             500                505                510
Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
         515                520                525
Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
     530                535                540
Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
 545                550                555                560
Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                 565                570                575
Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
             580                585                590
Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
         595                600                605
Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
     610                615                620
Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
 625                630                635                640
Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                 645                650                655
Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
             660                665                670
Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
         675                680                685
Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
     690                695                700
Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
 705                710                715                720
Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                 725                730                735
Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
             740                745                750
Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
         755                760                765
Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
     770                775                780
Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
 785                790                795                800
Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                 805                810                815
Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
             820                825                830
Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
         835                840                845
Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
     850                855                860
Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
 865                870                875                880
Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                 885                890                895
Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
             900                905                910
Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
         915                920                925
Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
     930                935                940
Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
 945                950                955                960
Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                 965                970                975
Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
             980                985                990
Glu Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser 
         995                1000                1005
Phe Ser Cys Leu Cys Pro Val Gly Phe Thr Gly Ser Phe Cys Leu His 
     1010                1015                1020
Glu Ile Asn Glu Cys Ser Ser His Pro Cys Leu Asn Glu Gly Thr Cys 
 1025                1030                1035                1040
Val Asp Gly Leu Gly Thr Tyr Arg Cys Ser Cys Pro Leu Gly Tyr Thr 
                 1045                1050                1055
Gly Lys Asn Cys Gln Thr Leu Val Asn Leu Cys Ser Arg Ser Pro Cys 
             1060                1065                1070
Lys Asn Lys Gly Thr Cys Val Gln Lys Lys Ala Glu Ser Gln Cys Leu 
         1075                1080                1085
Cys Pro Ser Gly Trp Ala Gly Ala Tyr Cys Asp Val Pro Asn Val Ser 
     1090                1095                1100
Cys Asp Ile Ala Ala Ser Arg Arg Gly Val Leu Val Glu His Leu Cys 
 1105                1110                1115                1120
Gln His Ser Gly Val Cys Ile Asn Ala Gly Asn Thr His Tyr Cys Gln 
                 1125                1130                1135
Cys Pro Leu Gly Tyr Thr Gly Ser Tyr Cys Glu Glu Gln Leu Asp Glu 
             1140                1145                1150
Cys Ala Ser Asn Pro Cys Gln His Gly Ala Thr Cys Ser Asp Phe Ile 
         1155                1160                1165
Gly Gly Tyr Arg Cys Glu Cys Val Pro Gly Tyr Gln Gly Val Asn Cys 
     1170                1175                1180
Glu Tyr Glu Val Asp Glu Cys Gln Asn Gln Pro Cys Gln Asn Gly Gly 
 1185                1190                1195                1200
Thr Cys Ile Asp Leu Val Asn His Phe Lys Cys Ser Cys Pro Pro Gly 
                 1205                1210                1215
Thr Arg Gly Leu Leu Cys Glu Glu Asn Ile Asp Asp Cys Ala Arg Gly 
             1220                1225                1230
Pro His Cys Leu Asn Gly Gly Gln Cys Met Asp Arg Ile Gly Gly Tyr 
         1235                1240                1245
Ser Cys Arg Cys Leu Pro Gly Phe Ala Gly Glu Arg Cys Glu Gly Asp 
     1250                1255                1260
Ile Asn Glu Cys Leu Ser Asn Pro Cys Ser Ser Glu Gly Ser Leu Asp 
 1265                1270                1275                1280
Cys Ile Gln Leu Thr Asn Asp Tyr Leu Cys Val Cys Arg Ser Ala Phe 
                 1285                1290                1295
Thr Gly Arg His Cys Glu Thr Phe Val Asp Val Cys Pro Gln Met Pro 
             1300                1305                1310
Cys Leu Asn Gly Gly Thr Cys Ala Val Ala Ser Asn Met Pro Asp Gly 
         1315                1320                1325
Phe Ile Cys Arg Cys Pro Pro Gly Phe Ser Gly Ala Arg Cys Gln Ser 
     1330                1335                1340
Ser Cys Gly Gln Val Lys Cys Arg Lys Gly Glu Gln Cys Val His Thr 
 1345                1350                1355                1360
Ala Ser Gly Pro Arg Cys Phe Cys Pro Ser Pro Arg Asp Cys Glu Ser 
                 1365                1370                1375
Gly Cys Ala Ser Ser Pro Cys Gln His Gly Gly Ser Cys His Pro Gln 
             1380                1385                1390
Arg Gln Pro Pro Tyr Tyr Ser Cys Gln Cys Ala Pro Pro Phe Ser Gly 
         1395                1400                1405
Ser Arg Cys Glu Leu Tyr Thr Ala Pro Pro Ser Thr Pro Pro Ala Thr 
     1410                1415                1420
Cys Leu Ser Gln Tyr Cys Ala Asp Lys Ala Arg Asp Gly Val Cys Asp 
 1425                1430                1435                1440
Glu Ala Cys Asn Ser His Ala Cys Gln Trp Asp Gly Gly Asp Cys Ser 
                 1445                1450                1455
Leu Thr Met Glu Asn Pro Trp Ala Asn Cys Ser Ser Pro Leu Pro Cys 
             1460                1465                1470
Trp Asp Tyr Ile Asn Asn Gln Cys Asp Glu Leu Cys Asn Thr Val Glu 
         1475                1480                1485
Cys Leu Phe Asp Asn Phe Glu Cys Gln Gly Asn Ser Lys Thr Cys Lys 
     1490                1495                1500
Tyr Asp Lys Tyr Cys Ala Asp His Phe Lys Asp Asn His Cys Asp Gln 
 1505                1510                1515                1520
Gly Cys Asn Ser Glu Glu Cys Gly Trp Asp Gly Leu Asp Cys Ala Ala 
                 1525                1530                1535
Asp Gln Pro Glu Asn Leu Ala Glu Gly Thr Leu Val Ile Val Val Leu 
             1540                1545                1550
Met Pro Pro Glu Gln Leu Leu Gln Asp Ala Arg Ser Phe Leu Arg Ala 
         1555                1560                1565
Leu Gly Thr Leu Leu His Thr Asn Leu Arg Ile Lys Arg Asp Ser Gln 
     1570                1575                1580
Gly Glu Leu Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met 
 1585                1590                1595                1600
Lys Lys Gln Arg Met Thr Arg Arg Ser Leu Pro Gly Glu Gln Glu Gln 
                 1605                1610                1615
Glu Val Ala Gly Ser Lys Val Phe Leu Glu Ile Asp Asn Arg Gln Cys 
             1620                1625                1630
Val Gln Asp Ser Asp His Cys Phe Lys Asn Thr Asp Ala Ala Ala Ala 
         1635                1640                1645
Leu Leu Ala Ser His Ala Ile Gln Gly Thr Leu Ser Tyr Pro Leu Val 
     1650                1655                1660
Ser Val Val Ser Glu Ser Leu Thr Pro Glu Arg Thr Gln Leu Leu Tyr 
 1665                1670                1675                1680
Leu Leu Ala Val Ala Val Val Ile Ile Leu Phe Ile Ile Leu Leu Gly 
                 1685                1690                1695
Val Ile Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro 
             1700                1705                1710
Glu Gly Phe Thr Leu Arg Arg Asp Ala Ser Asn His Lys Arg Arg Glu 
         1715                1720                1725
Pro Val Gly Gln Asp Ala Val Gly Leu Lys Asn Leu Ser Val Gln Val 
     1730                1735                1740
Ser Glu Ala Asn Leu Ile Gly Thr Gly Thr Ser Glu His Trp Val Asp 
 1745                1750                1755                1760
Asp Glu Gly Pro Gln Pro Lys Lys Val Lys Ala Glu Asp Glu Ala Leu 
                 1765                1770                1775
Leu Ser Glu Glu Asp Asp Pro Ile Asp Arg Arg Pro Trp Thr Gln Gln 
             1780                1785                1790
His Leu Glu Ala Ala Asp Ile Arg Arg Thr Pro Ser Leu Ala Leu Thr 
         1795                1800                1805
Pro Pro Gln Ala Glu Gln Glu Val Asp Val Leu Asp Val Asn Val Arg 
     1810                1815                1820
Gly Pro Asp Gly Cys Thr Pro Leu Met Leu Ala Ser Leu Arg Gly Gly 
 1825                1830                1835                1840
Ser Ser Asp Leu Ser Asp Glu Asp Glu Asp Ala Glu Asp Ser Ser Ala 
                 1845                1850                1855
Asn Ile Ile Thr Asp Leu Val Tyr Gln Gly Ala Ser Leu Gln Ala Gln 
             1860                1865                1870
Thr Asp Arg Thr Gly Glu Met Ala Leu His Leu Ala Ala Arg Tyr Ser 
         1875                1880                1885
Arg Ala Asp Ala Ala Lys Arg Leu Leu Asp Ala Gly Ala Asp Ala Asn 
     1890                1895                1900
Ala Gln Asp Asn Met Gly Arg Cys Pro Leu His Ala Ala Val Ala Ala 
 1905                1910                1915                1920
Asp Ala Gln Gly Val Phe Gln Ile Leu Ile Arg Asn Arg Val Thr Asp 
                 1925                1930                1935
Leu Asp Ala Arg Met Asn Asp Gly Thr Thr Pro Leu Ile Leu Ala Ala 
             1940                1945                1950
Arg Leu Ala Val Glu Gly Met Val Ala Glu Leu Ile Asn Cys Gln Ala 
         1955                1960                1965
Asp Val Asn Ala Val Asp Asp His Gly Lys Ser Ala Leu His Trp Ala 
     1970                1975                1980
Ala Ala Val Asn Asn Val Glu Ala Thr Leu Leu Leu Leu Lys Asn Gly 
 1985                1990                1995                2000
Ala Asn Arg Asp Met Gln Asp Asn Lys Glu Glu Thr Pro Leu Phe Leu 
                 2005                2010                2015
Ala Ala Arg Glu Gly Ser Tyr Glu Ala Ala Lys Ile Leu Leu Asp His 
             2020                2025                2030
Phe Ala Asn Arg Asp Ile Thr Asp His Met Asp Arg Leu Pro Arg Asp 
         2035                2040                2045
Val Ala Arg Asp Arg Met His His Asp Ile Val Arg Leu Leu Asp Glu 
     2050                2055                2060
Tyr Asn Val Thr Pro Ser Pro Pro Gly Thr Val Leu Thr Ser Ala Leu 
 2065                2070                2075                2080
Ser Pro Val Ile Cys Gly Pro Asn Arg Ser Phe Leu Ser Leu Lys His 
                 2085                2090                2095
Thr Pro Met Gly Lys Lys Ser Arg Arg Pro Ser Ala Lys Ser Thr Met 
             2100                2105                2110
Pro Thr Ser Leu Pro Asn Leu Ala Lys Glu Ala Lys Asp Ala Lys Gly 
         2115                2120                2125
Ser Arg Arg Lys Lys Ser Leu Ser Glu Lys Val Gln Leu Ser Glu Ser 
     2130                2135                2140
Ser Val Thr Leu Ser Pro Val Asp Ser Leu Glu Ser Pro His Thr Tyr 
 2145                2150                2155                2160
Val Ser Asp Thr Thr Ser Ser Pro Met Ile Thr Ser Pro Gly Ile Leu 
                 2165                2170                2175
Gln Ala Ser Pro Asn Pro Met Leu Ala Thr Ala Ala Pro Pro Ala Pro 
             2180                2185                2190
Val His Ala Gln His Ala Leu Ser Phe Ser Asn Leu His Glu Met Gln 
         2195                2200                2205
Pro Leu Ala His Gly Ala Ser Thr Val Leu Pro Ser Val Ser Gln Leu 
     2210                2215                2220
Leu Ser His His His Ile Val Ser Pro Gly Ser Gly Ser Ala Gly Ser 
 2225                2230                2235                2240
Leu Ser Arg Leu His Pro Val Pro Val Pro Ala Asp Trp Met Asn Arg 
                 2245                2250                2255
Met Glu Val Asn Glu Thr Gln Tyr Asn Glu Met Phe Gly Met Val Leu 
             2260                2265                2270
Ala Pro Ala Glu Gly Thr His Pro Gly Ile Ala Pro Gln Ser Arg Pro 
         2275                2280                2285
Pro Glu Gly Lys His Ile Thr Thr Pro Arg Glu Pro Leu Pro Pro Ile 
     2290                2295                2300
Val Thr Phe Gln Leu Ile Pro Lys Gly Ser Ile Ala Gln Pro Ala Gly 
 2305                2310                2315                2320
Ala Pro Gln Pro Gln Ser Thr Cys Pro Pro Ala Val Ala Gly Pro Leu 
                 2325                2330                2335
Pro Thr Met Tyr Gln Ile Pro Glu Met Ala Arg Leu Pro Ser Val Ala 
             2340                2345                2350
Phe Pro Thr Ala Met Met Pro Gln Gln Asp Gly Gln Val Ala Gln Thr 
         2355                2360                2365
Ile Leu Pro Ala Tyr His Pro Phe Pro Ala Ser Val Gly Lys Tyr Pro 
     2370                2375                2380
Thr Pro Pro Ser Gln His Ser Tyr Ala Ser Ser Asn Ala Ala Glu Arg 
 2385                2390                2395                2400
Thr Pro Ser His Ser Gly His Leu Gln Gly Glu His Pro Tyr Leu Thr 
                 2405                2410                2415
Pro Ser Pro Glu Ser Pro Asp Gln Trp Ser Ser Ser Ser Pro His Ser 
             2420                2425                2430
Ala Ser Asp Trp Ser Asp Val Thr Thr Ser Pro Thr Pro Gly Gly Ala 
         2435                2440                2445
Gly Gly Gly Gln Arg Gly Pro Gly Thr His Met Ser Glu Pro Pro His 
     2450                2455                2460
Asn Asn Met Gln Val Tyr Ala 
 2465                2470



<210> 9660
<211> 2674
<212> DNA
<213> Rattus norvegicus
<308> X57523
<400> 9660

cgcggagag  tccaggctg  gaccggact  tggacagcg  acgctcgat  gctgcgcac  60
cctggccga  ggccgcctt  ctgctgctg  tggtggact  gctgctgct  cggcccgtg  120
tcccgggaa  cttctccct  ttggttccc  aggtgccac  gctccgggt  tgggccgtg  180
gcctgagtc  ctgggctat  ctgggacta  gggtccgcg  ggtcctcgg  gtcaccgcg  240
gagcccgtg  ctggctggc  gctttgcag  cgctggtgg  ggcgctggg  ttggccctg  300
ctggacttg  ctcgttccg  aagctgtcc  cctggggag  actccggga  ggtgacaac  360
ctggactgc  ccactggaa  agtcgctta  atgccttcg  tctcagtta  gtggccgca  420
tgcccgcag  tgccctgtg  cacaagttg  ggggcttct  ggcgcccag  ggccacaag  480
gcgctggag  catgctgtg  cggatgcta  gcttcctgg  ctccaagaa  gggcgtctc  540
acctggttc  ggttctctt  atcctctcc  gccttgggg  aatggccat  cccttcttc  600
caggccgca  cactgactg  atccttcag  ataagacag  ccccagctt  gcccgcaac  660
tgtggctca  gtgtattct  accatagcc  gtacagtgc  ggagtttgc  ggagatgga  720
tctacaaca  caccatggg  cacatgcac  gccgcgtgc  tggagaggt  tttcgggcc  780
tccttcacc  ggagacagg  tttttcctg  agaacccaa  aggttccat  acatctcgg  840
tgactgagg  cacctccaa  gtgtgcgag  ccattagtg  caagctgaa  ctgttcctg  900
ggtacctgg  gcgaggcct  tgtctcctg  cgttcatga  ttgggggtc  ttctacctc  960
ctgtggtca  cctgctcag  ctgcctctg  ttttccttc  gcccaggag  ctggggaaa  1020
tgtaccagt  actggcagt  aaggtgcag  agtctctag  aaagtccac  caggtggcc  1080
tcgaggccc  gtcggcgat  cctaccgta  ggagctttg  caacgagga  ggagaggcc  1140
agaagttta  gcagaagtt  gaagaaatg  agccgctaa  caagaaaga  gccttggct  1200
acgtcactg  agtctggac  atgagtgtc  cgggaatgc  gctgaaggt  ggaattctg  1260
acctcggtg  gcagctggt  gtcagaggg  ctgtcagca  cggcaacct  gtctccttt  1320
ttctctacc  gcttcagtt  accagggcc  tggaggtcc  gctctccat  tatccctcc  1380
tgcagaagt  cgtgggcgc  tcggagaaa  tattcgaat  cctggaccg  actccctgc  1440
ctccgctca  tggctcact  gcaccttta  acatgaaag  cctcgtcaa  ttccaagat  1500
tctcctttg  ctacccaaa  catcccaac  tccaggtgc  tcaggggct  acttttacg  1560
tgtatcccg  gaaggtgac  gccttggtg  gacccaatg  gtcagggaa  agcaccgtg  1620
ccgccctgc  gcagaacct  taccagccc  ccgggggca  ggtgctcct  gatggcgag  1680
ccctggtcc  gtatgatca  cactacctg  acacgcagg  ggccgcagt  ggacaagag  1740
cactgctat  tggaagaag  tttcgggaa  atattgcct  tggcctgac  cggactcca  1800
ccatggagg  aatcacagc  gtggccatg  agtccggag  ccacgattt  atctctgga  1860
tccctcagg  ctatgacac  gaggtaggt  aaactggga  ccagctgtc  ggaggtcag  1920
gacaggcgg  ggccttggc  cgagccttg  tccggaagc  acgcctgct  atcttggac  1980
atgccacca  tgccctgga  gctggcaac  agctacggg  ccagcggct  ctgtatgag  2040
gccccgagt  ggcctctcg  acggttctt  tgatcaccc  gcagctcag  ctggcagag  2100
gggcccacc  catcctctt  ctcaaagaa  gctctgtct  cgagcaggg  acccacctg  2160
agctcatgg  gagaggagg  tgttaccgg  ccatggtgg  ggctcttgc  gctccttca  2220
actgacggg  ttctggact  caagctgcg  gagtccctc  ccctgctgt  ctctgctct  2280
tgtggcgga  aacctggga  caaagattt  accacatcc  cggagatag  tgaggagcg  2340
tggtgtttg  tacatgagg  aaatgtaac  tctaggaga  gcccggaat  taccacnaa  2400
gttttcccg  cccgccccc  gttagacgg  ggatggggg  aggtacccc  ggctaacac  2460
gagctgctg  gtctcctgt  tcccgtgga  tttgcatca  ggcatgcgc  cacaaacct  2520
gcttatgtg  cgttgggac  gaatgagaa  aaacgctca  aatgtacag  gaaggggca  2580
atagcttgc  attaaccaa  ggcataggc  ggcctatgg  tgttccgcg  gttcttgat  2640
tttataata  aactggtgt  ttgtaaaaa  aaaa  2674



<210> 9661
<211> 725
<212> PRT
<213> Rattus norvegicus
<308> P36370
<400> 9661

Met Ala Ala His Ala Trp Pro Thr Ala Ala Leu Leu Leu Leu Leu Val 
  1               5                  10                  15
Asp Trp Leu Leu Leu Arg Pro Val Leu Pro Gly Ile Phe Ser Leu Leu 
             20                  25                  30
Val Pro Glu Val Pro Leu Leu Arg Val Trp Ala Val Gly Leu Ser Arg 
         35                  40                  45
Trp Ala Ile Leu Gly Leu Gly Val Arg Gly Val Leu Gly Val Thr Ala 
     50                  55                  60
Gly Ala Arg Gly Trp Leu Ala Ala Leu Gln Pro Leu Val Ala Ala Leu 
 65                  70                  75                  80
Gly Leu Ala Leu Pro Gly Leu Ala Ser Phe Arg Lys Leu Ser Ala Trp 
                 85                  90                  95
Gly Ala Leu Arg Glu Gly Asp Asn Ala Gly Leu Leu His Trp Asn Ser 
             100                105                110
Arg Leu Asp Ala Phe Val Leu Ser Tyr Val Ala Ala Leu Pro Ala Ala 
         115                120                125
Ala Leu Trp His Lys Leu Gly Gly Phe Trp Ala Pro Ser Gly His Lys 
     130                135                140
Gly Ala Gly Asp Met Leu Cys Arg Met Leu Gly Phe Leu Asp Ser Lys 
 145                150                155                160
Lys Gly Arg Leu His Leu Val Leu Val Leu Leu Ile Leu Ser Cys Leu 
                 165                170                175
Gly Glu Met Ala Ile Pro Phe Phe Thr Gly Arg Ile Thr Asp Trp Ile 
             180                185                190
Leu Gln Asp Lys Thr Ala Pro Ser Phe Ala Arg Asn Met Trp Leu Met 
         195                200                205
Cys Ile Leu Thr Ile Ala Ser Thr Val Leu Glu Phe Ala Gly Asp Gly 
     210                215                220
Ile Tyr Asn Ile Thr Met Gly His Met His Ser Arg Val His Gly Glu 
 225                230                235                240
Val Phe Arg Ala Val Leu His Gln Glu Thr Gly Phe Phe Leu Lys Asn 
                 245                250                255
Pro Thr Gly Ser Ile Thr Ser Arg Val Thr Glu Asp Thr Ser Asn Val 
             260                265                270
Cys Glu Ser Ile Ser Asp Lys Leu Asn Leu Phe Leu Trp Tyr Leu Gly 
         275                280                285
Arg Gly Leu Cys Leu Leu Ala Phe Met Ile Trp Gly Ser Phe Tyr Leu 
     290                295                300
Thr Val Val Thr Leu Leu Ser Leu Pro Leu Leu Phe Leu Leu Pro Arg 
 305                310                315                320
Arg Leu Gly Lys Val Tyr Gln Ser Leu Ala Val Lys Val Gln Glu Ser 
                 325                330                335
Leu Ala Lys Ser Thr Gln Val Ala Leu Glu Ala Leu Ser Ala Met Pro 
             340                345                350
Thr Val Arg Ser Phe Ala Asn Glu Glu Gly Glu Ala Gln Lys Phe Arg 
         355                360                365
Gln Lys Leu Glu Glu Met Lys Pro Leu Asn Lys Lys Glu Ala Leu Ala 
     370                375                380
Tyr Val Thr Glu Val Trp Thr Met Ser Val Ser Gly Met Leu Leu Lys 
 385                390                395                400
Val Gly Ile Leu Tyr Leu Gly Gly Gln Leu Val Val Arg Gly Ala Val 
                 405                410                415
Ser Ser Gly Asn Leu Val Ser Phe Val Leu Tyr Gln Leu Gln Phe Thr 
             420                425                430
Arg Ala Val Glu Val Leu Leu Ser Ile Tyr Pro Ser Met Gln Lys Ser 
         435                440                445
Val Gly Ala Ser Glu Lys Ile Phe Glu Tyr Leu Asp Arg Thr Pro Cys 
     450                455                460
Ser Pro Leu Ser Gly Ser Leu Ala Pro Leu Asn Met Lys Gly Leu Val 
 465                470                475                480
Lys Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn His Pro Asn Val Gln 
                 485                490                495
Val Leu Gln Gly Leu Thr Phe Thr Leu Tyr Pro Gly Lys Val Thr Ala 
             500                505                510
Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val Ala Ala Leu Leu 
         515                520                525
Gln Asn Leu Tyr Gln Pro Thr Gly Gly Lys Val Leu Leu Asp Gly Glu 
     530                535                540
Pro Leu Val Gln Tyr Asp His His Tyr Leu His Thr Gln Val Ala Ala 
 545                550                555                560
Val Gly Gln Glu Pro Leu Leu Phe Gly Arg Ser Phe Arg Glu Asn Ile 
                 565                570                575
Ala Tyr Gly Leu Thr Arg Thr Pro Thr Met Glu Glu Ile Thr Ala Val 
             580                585                590
Ala Met Glu Ser Gly Ala His Asp Phe Ile Ser Gly Phe Pro Gln Gly 
         595                600                605
Tyr Asp Thr Glu Val Gly Glu Thr Gly Asn Gln Leu Ser Gly Gly Gln 
     610                615                620
Arg Gln Ala Val Ala Leu Ala Arg Ala Leu Ile Arg Lys Pro Arg Leu 
 625                630                635                640
Leu Ile Leu Asp Asp Ala Thr Ser Ala Leu Asp Ala Gly Asn Gln Leu 
                 645                650                655
Arg Val Gln Arg Leu Leu Tyr Glu Ser Pro Glu Trp Ala Ser Arg Thr 
             660                665                670
Val Leu Leu Ile Thr Gln Gln Leu Ser Leu Ala Glu Arg Ala His His 
         675                680                685
Ile Leu Phe Leu Lys Glu Gly Ser Val Cys Glu Gln Gly Thr His Leu 
     690                695                700
Gln Leu Met Glu Arg Gly Gly Cys Tyr Arg Ser Met Val Glu Ala Leu 
 705                710                715                720
Ala Ala Pro Ser Asp 
                 725



<210> 9662
<211> 2474
<212> DNA
<213> Homo sapiens
<308> M84748
<400> 9662

gctgcggtc  ccccgccgc  gctgagcca  gcggctccc  gacctgaga  cctggacct  60
cctgctgct  gtggacgcg  ctttactgt  gctgcttca  ggccctctg  ggactttgc  120
tcctcaagg  ctgccagga  tatggctgg  ggggaccct  cggctggga  ggctgtggg  180
gctgctaaa  ctaagaggg  tgctgggat  tgtggggac  ctgctgctc  cgctctgtc  240
ggccacccc  ctgactgtc  ccctgagag  cctggtcgc  ggggcctca  gtgctcccc  300
agccagagt  gcttcagcc  cttggagct  gctgctggt  gggtacggg  ctgcggggc  360
cagctggtc  ctgtgggct  ttctgagcc  tcctggagc  caggagaag  agcaggacc  420
ggtgaacaa  aaagtcttg  tgtggaggc  gctgaagct  tccaggccg  acctgcctc  480
cctcgttgc  gccttcttc  tccttgtcc  tgctgtctt  ggtgagaca  taatccctc  540
ctattctgg  cgtgtgatt  acatcctgg  aggtgattt  gacccccat  cctttgcca  600
tgccatctt  ttcatgtgc  tcttctcct  tggcagctc  ctgtctgca  gctgccgag  660
aggctgctt  acctacacc  tgtctcgaa  caacttgcg  atccgggag  agcttttct  720
ctccctgct  cgccaggac  tcggtttct  ccaggagac  aagacaggg  agctgaact  780
acggctgag  tcggatacc  ccctgatga  taactggct  cctttaaat  ccaatgtgc  840
cttgcgaag  ctggtgaaa  tggtggggc  gtatggctt  atgctcagc  tatcgcctc  900
actcaccct  ctttctctg  tgcacatgc  cttcacaat  gcagcggag  aggtgtaca  960
cacccgcca  caggaagtg  ttcgggaga  ccaggatgc  gtggccagg  cggggcagg  1020
ggtgcggga  gccgttgga  ggctgcaga  cgttcgcag  tttggggcc  aggagcatg  1080
agtctgtcg  tataaagag  cccttgaac  atgtcggca  ctgtattgg  ggagagacc  1140
ggaacgcgc  ttgtacctg  tcgtaagga  ggtgctgca  ttgggggtg  agatgctga  1200
gctgagctg  gggctgcag  agatgcagg  tggggagct  acccagggc  gcctgcttt  1260
ctttatgat  taccaggag  gcgtgggga  ctatgtgca  accctggta  acatatatg  1320
ggatatgct  agcaacgtg  gagctgcag  gaaggtttt  tcctacatg  accgacagc  1380
aaatctgcc  tcacctggc  cgcttgccc  caccactct  cagggggtt  tgaaattcc  1440
agacgtctc  tttgcatat  ccaatcgcc  tgacaggcc  gtgctcaag  ggctgacgt  1500
taccctacg  cctggtgag  tgacggcgc  ggtgggacc  aatgggtct  ggaagagca  1560
agtggctgc  ctgctgcag  atctgtacc  gcccacagg  ggacaggtg  tgctggatg  1620
aaagcccat  tcacagtat  aacactgct  cctgcacag  caggtggtt  cagttgggc  1680
ggagcctgt  ctgttctcc  gttctgtga  gaacaacat  gcttatggg  tgcagagct  1740
cgaagatga  aaggtgatg  cggctgccc  ggctgccca  gcagatgac  tcatccagg  1800
aatggagca  ggaatatac  cagatgtag  ggagaaggg  agccagctg  ctgcgggac  1860
gaaacaacg  ctggccatt  cccgggccc  tgtacgaga  ccgcgggtc  tcatcctgg  1920
tgaggctac  agtgcccta  atgtgcagt  cgagcaggc  ctgcaggac  ggaattccc  1980
tggggatcg  acagtgctg  tgattgctc  caggctgca  acagttcag  gcgcccacc  2040
gatcctggt  ctccaggag  gcaagctgc  gaagcttgc  cagctctag  agggacagg  2100
cctctattc  cgcctggtg  agcagcggc  gatggactg  ggccccagg  atactgggc  2160
ctcttctca  gggcgtctc  aggacccag  gctgttcct  ctttgagtt  ccctagagc  2220
gtgcggcca  atagctgtt  ctgagttgc  ggcacgatg  agatttgga  actgtgtgc  2280
tttggtggg  tagagaggt  gggtggggt  gggtggggg  tgtctgtgt  caggaaact  2340
aattccctg  tgactagag  tttgcctgg  gatgaggag  attttgtgg  ataatacat  2400
tattttaaa  tattttcct  cttacatga  ctgtataca  tcatataga  aatttagac  2460
atataaaaa  gtac  2474



<210> 9663
<211> 686
<212> PRT
<213> Homo sapiens
<308> Q03519
<400> 9663

Met Arg Leu Pro Asp Leu Arg Pro Trp Thr Ser Leu Leu Leu Val Asp 
  1               5                  10                  15
Ala Ala Leu Leu Trp Leu Leu Gln Gly Pro Leu Gly Thr Leu Leu Pro 
             20                  25                  30
Gln Gly Leu Pro Gly Leu Trp Leu Glu Gly Thr Leu Arg Leu Gly Gly 
         35                  40                  45
Leu Trp Gly Leu Leu Lys Leu Arg Gly Leu Leu Gly Phe Val Gly Thr 
     50                  55                  60
Leu Leu Leu Pro Leu Cys Leu Ala Thr Pro Leu Thr Val Ser Leu Arg 
 65                  70                  75                  80
Ala Leu Val Ala Gly Ala Ser Arg Ala Pro Pro Ala Arg Val Ala Ser 
                 85                  90                  95
Ala Pro Trp Ser Trp Leu Leu Val Gly Tyr Gly Ala Ala Gly Leu Ser 
             100                105                110
Trp Ser Leu Trp Ala Val Leu Ser Pro Pro Gly Ala Gln Glu Lys Glu 
         115                120                125
Gln Asp Gln Val Asn Asn Lys Val Leu Met Trp Arg Leu Leu Lys Leu 
     130                135                140
Ser Arg Pro Asp Leu Pro Leu Leu Val Ala Ala Phe Phe Phe Leu Val 
 145                150                155                160
Leu Ala Val Leu Gly Glu Thr Leu Ile Pro His Tyr Ser Gly Arg Val 
                 165                170                175
Ile Asp Ile Leu Gly Gly Asp Phe Asp Pro His Ala Phe Ala Ser Ala 
             180                185                190
Ile Phe Phe Met Cys Leu Phe Ser Phe Gly Ser Ser Leu Ser Ala Gly 
         195                200                205
Cys Arg Gly Gly Cys Phe Thr Tyr Thr Met Ser Arg Ile Asn Leu Arg 
     210                215                220
Ile Arg Glu Gln Leu Phe Ser Ser Leu Leu Arg Gln Asp Leu Gly Phe 
 225                230                235                240
Phe Gln Glu Thr Lys Thr Gly Glu Leu Asn Ser Arg Leu Ser Ser Asp 
                 245                250                255
Thr Thr Leu Met Ser Asn Trp Leu Pro Leu Asn Ala Asn Val Leu Leu 
             260                265                270
Arg Ser Leu Val Lys Val Val Gly Leu Tyr Gly Phe Met Leu Ser Ile 
         275                280                285
Ser Pro Arg Leu Thr Leu Leu Ser Leu Leu His Met Pro Phe Thr Ile 
     290                295                300
Ala Ala Glu Lys Val Tyr Asn Thr Arg His Gln Glu Val Leu Arg Glu 
 305                310                315                320
Ile Gln Asp Ala Val Ala Arg Ala Gly Gln Val Val Arg Glu Ala Val 
                 325                330                335
Gly Gly Leu Gln Thr Val Arg Ser Phe Gly Ala Glu Glu His Glu Val 
             340                345                350
Cys Arg Tyr Lys Glu Ala Leu Glu Gln Cys Arg Gln Leu Tyr Trp Arg 
         355                360                365
Arg Asp Leu Glu Arg Ala Leu Tyr Leu Leu Val Arg Arg Val Leu His 
     370                375                380
Leu Gly Val Gln Met Leu Met Leu Ser Cys Gly Leu Gln Gln Met Gln 
 385                390                395                400
Asp Gly Glu Leu Thr Gln Gly Ser Leu Leu Ser Phe Met Ile Tyr Gln 
                 405                410                415
Glu Ser Val Gly Ser Tyr Val Gln Thr Leu Val Tyr Ile Tyr Gly Asp 
             420                425                430
Met Leu Ser Asn Val Gly Ala Ala Glu Lys Val Phe Ser Tyr Met Asp 
         435                440                445
Arg Gln Pro Asn Leu Pro Ser Pro Gly Thr Leu Ala Pro Thr Thr Leu 
     450                455                460
Gln Gly Val Val Lys Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn Arg 
 465                470                475                480
Pro Asp Arg Pro Val Leu Lys Gly Leu Thr Phe Thr Leu Arg Pro Gly 
                 485                490                495
Glu Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val 
             500                505                510
Ala Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly Gln Val Leu 
         515                520                525
Leu Asp Glu Lys Pro Ile Ser Gln Tyr Glu His Cys Tyr Leu His Ser 
     530                535                540
Gln Val Val Ser Val Gly Gln Glu Pro Val Leu Phe Ser Gly Ser Val 
 545                550                555                560
Arg Asn Asn Ile Ala Tyr Gly Leu Gln Ser Cys Glu Asp Asp Lys Val 
                 565                570                575
Met Ala Ala Ala Gln Ala Ala His Ala Asp Asp Phe Ile Gln Glu Met 
             580                585                590
Glu His Gly Ile Tyr Thr Asp Val Gly Glu Lys Gly Ser Gln Leu Ala 
         595                600                605
Ala Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg Ala Leu Val Arg Asp 
     610                615                620
Pro Arg Val Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Val Gln 
 625                630                635                640
Cys Glu Gln Ala Leu Gln Asp Trp Asn Ser Arg Gly Asp Arg Thr Val 
                 645                650                655
Leu Val Ile Ala His Arg Leu Gln Thr Val Gln Arg Ala His Gln Ile 
             660                665                670
Leu Val Leu Gln Glu Gly Lys Leu Gln Lys Leu Ala Gln Leu 
         675                680                685



<210> 9664
<211> 2674
<212> DNA
<213> Rattus norvegicus
<308> X57523
<400> 9664

cgcggagag  tccaggctg  gaccggact  tggacagcg  acgctcgat  gctgcgcac  60
cctggccga  ggccgcctt  ctgctgctg  tggtggact  gctgctgct  cggcccgtg  120
tcccgggaa  cttctccct  ttggttccc  aggtgccac  gctccgggt  tgggccgtg  180
gcctgagtc  ctgggctat  ctgggacta  gggtccgcg  ggtcctcgg  gtcaccgcg  240
gagcccgtg  ctggctggc  gctttgcag  cgctggtgg  ggcgctggg  ttggccctg  300
ctggacttg  ctcgttccg  aagctgtcc  cctggggag  actccggga  ggtgacaac  360
ctggactgc  ccactggaa  agtcgctta  atgccttcg  tctcagtta  gtggccgca  420
tgcccgcag  tgccctgtg  cacaagttg  ggggcttct  ggcgcccag  ggccacaag  480
gcgctggag  catgctgtg  cggatgcta  gcttcctgg  ctccaagaa  gggcgtctc  540
acctggttc  ggttctctt  atcctctcc  gccttgggg  aatggccat  cccttcttc  600
caggccgca  cactgactg  atccttcag  ataagacag  ccccagctt  gcccgcaac  660
tgtggctca  gtgtattct  accatagcc  gtacagtgc  ggagtttgc  ggagatgga  720
tctacaaca  caccatggg  cacatgcac  gccgcgtgc  tggagaggt  tttcgggcc  780
tccttcacc  ggagacagg  tttttcctg  agaacccaa  aggttccat  acatctcgg  840
tgactgagg  cacctccaa  gtgtgcgag  ccattagtg  caagctgaa  ctgttcctg  900
ggtacctgg  gcgaggcct  tgtctcctg  cgttcatga  ttgggggtc  ttctacctc  960
ctgtggtca  cctgctcag  ctgcctctg  ttttccttc  gcccaggag  ctggggaaa  1020
tgtaccagt  actggcagt  aaggtgcag  agtctctag  aaagtccac  caggtggcc  1080
tcgaggccc  gtcggcgat  cctaccgta  ggagctttg  caacgagga  ggagaggcc  1140
agaagttta  gcagaagtt  gaagaaatg  agccgctaa  caagaaaga  gccttggct  1200
acgtcactg  agtctggac  atgagtgtc  cgggaatgc  gctgaaggt  ggaattctg  1260
acctcggtg  gcagctggt  gtcagaggg  ctgtcagca  cggcaacct  gtctccttt  1320
ttctctacc  gcttcagtt  accagggcc  tggaggtcc  gctctccat  tatccctcc  1380
tgcagaagt  cgtgggcgc  tcggagaaa  tattcgaat  cctggaccg  actccctgc  1440
ctccgctca  tggctcact  gcaccttta  acatgaaag  cctcgtcaa  ttccaagat  1500
tctcctttg  ctacccaaa  catcccaac  tccaggtgc  tcaggggct  acttttacg  1560
tgtatcccg  gaaggtgac  gccttggtg  gacccaatg  gtcagggaa  agcaccgtg  1620
ccgccctgc  gcagaacct  taccagccc  ccgggggca  ggtgctcct  gatggcgag  1680
ccctggtcc  gtatgatca  cactacctg  acacgcagg  ggccgcagt  ggacaagag  1740
cactgctat  tggaagaag  tttcgggaa  atattgcct  tggcctgac  cggactcca  1800
ccatggagg  aatcacagc  gtggccatg  agtccggag  ccacgattt  atctctgga  1860
tccctcagg  ctatgacac  gaggtaggt  aaactggga  ccagctgtc  ggaggtcag  1920
gacaggcgg  ggccttggc  cgagccttg  tccggaagc  acgcctgct  atcttggac  1980
atgccacca  tgccctgga  gctggcaac  agctacggg  ccagcggct  ctgtatgag  2040
gccccgagt  ggcctctcg  acggttctt  tgatcaccc  gcagctcag  ctggcagag  2100
gggcccacc  catcctctt  ctcaaagaa  gctctgtct  cgagcaggg  acccacctg  2160
agctcatgg  gagaggagg  tgttaccgg  ccatggtgg  ggctcttgc  gctccttca  2220
actgacggg  ttctggact  caagctgcg  gagtccctc  ccctgctgt  ctctgctct  2280
tgtggcgga  aacctggga  caaagattt  accacatcc  cggagatag  tgaggagcg  2340
tggtgtttg  tacatgagg  aaatgtaac  tctaggaga  gcccggaat  taccacnaa  2400
gttttcccg  cccgccccc  gttagacgg  ggatggggg  aggtacccc  ggctaacac  2460
gagctgctg  gtctcctgt  tcccgtgga  tttgcatca  ggcatgcgc  cacaaacct  2520
gcttatgtg  cgttgggac  gaatgagaa  aaacgctca  aatgtacag  gaaggggca  2580
atagcttgc  attaaccaa  ggcataggc  ggcctatgg  tgttccgcg  gttcttgat  2640
tttataata  aactggtgt  ttgtaaaaa  aaaa  2674



<210> 9665
<211> 725
<212> PRT
<213> Rattus norvegicus
<308> P36370
<400> 9665

Met Ala Ala His Ala Trp Pro Thr Ala Ala Leu Leu Leu Leu Leu Val 
  1               5                  10                  15
Asp Trp Leu Leu Leu Arg Pro Val Leu Pro Gly Ile Phe Ser Leu Leu 
             20                  25                  30
Val Pro Glu Val Pro Leu Leu Arg Val Trp Ala Val Gly Leu Ser Arg 
         35                  40                  45
Trp Ala Ile Leu Gly Leu Gly Val Arg Gly Val Leu Gly Val Thr Ala 
     50                  55                  60
Gly Ala Arg Gly Trp Leu Ala Ala Leu Gln Pro Leu Val Ala Ala Leu 
 65                  70                  75                  80
Gly Leu Ala Leu Pro Gly Leu Ala Ser Phe Arg Lys Leu Ser Ala Trp 
                 85                  90                  95
Gly Ala Leu Arg Glu Gly Asp Asn Ala Gly Leu Leu His Trp Asn Ser 
             100                105                110
Arg Leu Asp Ala Phe Val Leu Ser Tyr Val Ala Ala Leu Pro Ala Ala 
         115                120                125
Ala Leu Trp His Lys Leu Gly Gly Phe Trp Ala Pro Ser Gly His Lys 
     130                135                140
Gly Ala Gly Asp Met Leu Cys Arg Met Leu Gly Phe Leu Asp Ser Lys 
 145                150                155                160
Lys Gly Arg Leu His Leu Val Leu Val Leu Leu Ile Leu Ser Cys Leu 
                 165                170                175
Gly Glu Met Ala Ile Pro Phe Phe Thr Gly Arg Ile Thr Asp Trp Ile 
             180                185                190
Leu Gln Asp Lys Thr Ala Pro Ser Phe Ala Arg Asn Met Trp Leu Met 
         195                200                205
Cys Ile Leu Thr Ile Ala Ser Thr Val Leu Glu Phe Ala Gly Asp Gly 
     210                215                220
Ile Tyr Asn Ile Thr Met Gly His Met His Ser Arg Val His Gly Glu 
 225                230                235                240
Val Phe Arg Ala Val Leu His Gln Glu Thr Gly Phe Phe Leu Lys Asn 
                 245                250                255
Pro Thr Gly Ser Ile Thr Ser Arg Val Thr Glu Asp Thr Ser Asn Val 
             260                265                270
Cys Glu Ser Ile Ser Asp Lys Leu Asn Leu Phe Leu Trp Tyr Leu Gly 
         275                280                285
Arg Gly Leu Cys Leu Leu Ala Phe Met Ile Trp Gly Ser Phe Tyr Leu 
     290                295                300
Thr Val Val Thr Leu Leu Ser Leu Pro Leu Leu Phe Leu Leu Pro Arg 
 305                310                315                320
Arg Leu Gly Lys Val Tyr Gln Ser Leu Ala Val Lys Val Gln Glu Ser 
                 325                330                335
Leu Ala Lys Ser Thr Gln Val Ala Leu Glu Ala Leu Ser Ala Met Pro 
             340                345                350
Thr Val Arg Ser Phe Ala Asn Glu Glu Gly Glu Ala Gln Lys Phe Arg 
         355                360                365
Gln Lys Leu Glu Glu Met Lys Pro Leu Asn Lys Lys Glu Ala Leu Ala 
     370                375                380
Tyr Val Thr Glu Val Trp Thr Met Ser Val Ser Gly Met Leu Leu Lys 
 385                390                395                400
Val Gly Ile Leu Tyr Leu Gly Gly Gln Leu Val Val Arg Gly Ala Val 
                 405                410                415
Ser Ser Gly Asn Leu Val Ser Phe Val Leu Tyr Gln Leu Gln Phe Thr 
             420                425                430
Arg Ala Val Glu Val Leu Leu Ser Ile Tyr Pro Ser Met Gln Lys Ser 
         435                440                445
Val Gly Ala Ser Glu Lys Ile Phe Glu Tyr Leu Asp Arg Thr Pro Cys 
     450                455                460
Ser Pro Leu Ser Gly Ser Leu Ala Pro Leu Asn Met Lys Gly Leu Val 
 465                470                475                480
Lys Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn His Pro Asn Val Gln 
                 485                490                495
Val Leu Gln Gly Leu Thr Phe Thr Leu Tyr Pro Gly Lys Val Thr Ala 
             500                505                510
Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val Ala Ala Leu Leu 
         515                520                525
Gln Asn Leu Tyr Gln Pro Thr Gly Gly Lys Val Leu Leu Asp Gly Glu 
     530                535                540
Pro Leu Val Gln Tyr Asp His His Tyr Leu His Thr Gln Val Ala Ala 
 545                550                555                560
Val Gly Gln Glu Pro Leu Leu Phe Gly Arg Ser Phe Arg Glu Asn Ile 
                 565                570                575
Ala Tyr Gly Leu Thr Arg Thr Pro Thr Met Glu Glu Ile Thr Ala Val 
             580                585                590
Ala Met Glu Ser Gly Ala His Asp Phe Ile Ser Gly Phe Pro Gln Gly 
         595                600                605
Tyr Asp Thr Glu Val Gly Glu Thr Gly Asn Gln Leu Ser Gly Gly Gln 
     610                615                620
Arg Gln Ala Val Ala Leu Ala Arg Ala Leu Ile Arg Lys Pro Arg Leu 
 625                630                635                640
Leu Ile Leu Asp Asp Ala Thr Ser Ala Leu Asp Ala Gly Asn Gln Leu 
                 645                650                655
Arg Val Gln Arg Leu Leu Tyr Glu Ser Pro Glu Trp Ala Ser Arg Thr 
             660                665                670
Val Leu Leu Ile Thr Gln Gln Leu Ser Leu Ala Glu Arg Ala His His 
         675                680                685
Ile Leu Phe Leu Lys Glu Gly Ser Val Cys Glu Gln Gly Thr His Leu 
     690                695                700
Gln Leu Met Glu Arg Gly Gly Cys Tyr Arg Ser Met Val Glu Ala Leu 
 705                710                715                720
Ala Ala Pro Ser Asp 
                 725



<210> 9666
<211> 2474
<212> DNA
<213> Homo sapiens
<308> M84748
<400> 9666

gctgcggtc  ccccgccgc  gctgagcca  gcggctccc  gacctgaga  cctggacct  60
cctgctgct  gtggacgcg  ctttactgt  gctgcttca  ggccctctg  ggactttgc  120
tcctcaagg  ctgccagga  tatggctgg  ggggaccct  cggctggga  ggctgtggg  180
gctgctaaa  ctaagaggg  tgctgggat  tgtggggac  ctgctgctc  cgctctgtc  240
ggccacccc  ctgactgtc  ccctgagag  cctggtcgc  ggggcctca  gtgctcccc  300
agccagagt  gcttcagcc  cttggagct  gctgctggt  gggtacggg  ctgcggggc  360
cagctggtc  ctgtgggct  ttctgagcc  tcctggagc  caggagaag  agcaggacc  420
ggtgaacaa  aaagtcttg  tgtggaggc  gctgaagct  tccaggccg  acctgcctc  480
cctcgttgc  gccttcttc  tccttgtcc  tgctgtctt  ggtgagaca  taatccctc  540
ctattctgg  cgtgtgatt  acatcctgg  aggtgattt  gacccccat  cctttgcca  600
tgccatctt  ttcatgtgc  tcttctcct  tggcagctc  ctgtctgca  gctgccgag  660
aggctgctt  acctacacc  tgtctcgaa  caacttgcg  atccgggag  agcttttct  720
ctccctgct  cgccaggac  tcggtttct  ccaggagac  aagacaggg  agctgaact  780
acggctgag  tcggatacc  ccctgatga  taactggct  cctttaaat  ccaatgtgc  840
cttgcgaag  ctggtgaaa  tggtggggc  gtatggctt  atgctcagc  tatcgcctc  900
actcaccct  ctttctctg  tgcacatgc  cttcacaat  gcagcggag  aggtgtaca  960
cacccgcca  caggaagtg  ttcgggaga  ccaggatgc  gtggccagg  cggggcagg  1020
ggtgcggga  gccgttgga  ggctgcaga  cgttcgcag  tttggggcc  aggagcatg  1080
agtctgtcg  tataaagag  cccttgaac  atgtcggca  ctgtattgg  ggagagacc  1140
ggaacgcgc  ttgtacctg  tcgtaagga  ggtgctgca  ttgggggtg  agatgctga  1200
gctgagctg  gggctgcag  agatgcagg  tggggagct  acccagggc  gcctgcttt  1260
ctttatgat  taccaggag  gcgtgggga  ctatgtgca  accctggta  acatatatg  1320
ggatatgct  agcaacgtg  gagctgcag  gaaggtttt  tcctacatg  accgacagc  1380
aaatctgcc  tcacctggc  cgcttgccc  caccactct  cagggggtt  tgaaattcc  1440
agacgtctc  tttgcatat  ccaatcgcc  tgacaggcc  gtgctcaag  ggctgacgt  1500
taccctacg  cctggtgag  tgacggcgc  ggtgggacc  aatgggtct  ggaagagca  1560
agtggctgc  ctgctgcag  atctgtacc  gcccacagg  ggacaggtg  tgctggatg  1620
aaagcccat  tcacagtat  aacactgct  cctgcacag  caggtggtt  cagttgggc  1680
ggagcctgt  ctgttctcc  gttctgtga  gaacaacat  gcttatggg  tgcagagct  1740
cgaagatga  aaggtgatg  cggctgccc  ggctgccca  gcagatgac  tcatccagg  1800
aatggagca  ggaatatac  cagatgtag  ggagaaggg  agccagctg  ctgcgggac  1860
gaaacaacg  ctggccatt  cccgggccc  tgtacgaga  ccgcgggtc  tcatcctgg  1920
tgaggctac  agtgcccta  atgtgcagt  cgagcaggc  ctgcaggac  ggaattccc  1980
tggggatcg  acagtgctg  tgattgctc  caggctgca  acagttcag  gcgcccacc  2040
gatcctggt  ctccaggag  gcaagctgc  gaagcttgc  cagctctag  agggacagg  2100
cctctattc  cgcctggtg  agcagcggc  gatggactg  ggccccagg  atactgggc  2160
ctcttctca  gggcgtctc  aggacccag  gctgttcct  ctttgagtt  ccctagagc  2220
gtgcggcca  atagctgtt  ctgagttgc  ggcacgatg  agatttgga  actgtgtgc  2280
tttggtggg  tagagaggt  gggtggggt  gggtggggg  tgtctgtgt  caggaaact  2340
aattccctg  tgactagag  tttgcctgg  gatgaggag  attttgtgg  ataatacat  2400
tattttaaa  tattttcct  cttacatga  ctgtataca  tcatataga  aatttagac  2460
atataaaaa  gtac  2474



<210> 9667
<211> 686
<212> PRT
<213> Homo sapiens
<308> Q03519
<400> 9667

Met Arg Leu Pro Asp Leu Arg Pro Trp Thr Ser Leu Leu Leu Val Asp 
  1               5                  10                  15
Ala Ala Leu Leu Trp Leu Leu Gln Gly Pro Leu Gly Thr Leu Leu Pro 
             20                  25                  30
Gln Gly Leu Pro Gly Leu Trp Leu Glu Gly Thr Leu Arg Leu Gly Gly 
         35                  40                  45
Leu Trp Gly Leu Leu Lys Leu Arg Gly Leu Leu Gly Phe Val Gly Thr 
     50                  55                  60
Leu Leu Leu Pro Leu Cys Leu Ala Thr Pro Leu Thr Val Ser Leu Arg 
 65                  70                  75                  80
Ala Leu Val Ala Gly Ala Ser Arg Ala Pro Pro Ala Arg Val Ala Ser 
                 85                  90                  95
Ala Pro Trp Ser Trp Leu Leu Val Gly Tyr Gly Ala Ala Gly Leu Ser 
             100                105                110
Trp Ser Leu Trp Ala Val Leu Ser Pro Pro Gly Ala Gln Glu Lys Glu 
         115                120                125
Gln Asp Gln Val Asn Asn Lys Val Leu Met Trp Arg Leu Leu Lys Leu 
     130                135                140
Ser Arg Pro Asp Leu Pro Leu Leu Val Ala Ala Phe Phe Phe Leu Val 
 145                150                155                160
Leu Ala Val Leu Gly Glu Thr Leu Ile Pro His Tyr Ser Gly Arg Val 
                 165                170                175
Ile Asp Ile Leu Gly Gly Asp Phe Asp Pro His Ala Phe Ala Ser Ala 
             180                185                190
Ile Phe Phe Met Cys Leu Phe Ser Phe Gly Ser Ser Leu Ser Ala Gly 
         195                200                205
Cys Arg Gly Gly Cys Phe Thr Tyr Thr Met Ser Arg Ile Asn Leu Arg 
     210                215                220
Ile Arg Glu Gln Leu Phe Ser Ser Leu Leu Arg Gln Asp Leu Gly Phe 
 225                230                235                240
Phe Gln Glu Thr Lys Thr Gly Glu Leu Asn Ser Arg Leu Ser Ser Asp 
                 245                250                255
Thr Thr Leu Met Ser Asn Trp Leu Pro Leu Asn Ala Asn Val Leu Leu 
             260                265                270
Arg Ser Leu Val Lys Val Val Gly Leu Tyr Gly Phe Met Leu Ser Ile 
         275                280                285
Ser Pro Arg Leu Thr Leu Leu Ser Leu Leu His Met Pro Phe Thr Ile 
     290                295                300
Ala Ala Glu Lys Val Tyr Asn Thr Arg His Gln Glu Val Leu Arg Glu 
 305                310                315                320
Ile Gln Asp Ala Val Ala Arg Ala Gly Gln Val Val Arg Glu Ala Val 
                 325                330                335
Gly Gly Leu Gln Thr Val Arg Ser Phe Gly Ala Glu Glu His Glu Val 
             340                345                350
Cys Arg Tyr Lys Glu Ala Leu Glu Gln Cys Arg Gln Leu Tyr Trp Arg 
         355                360                365
Arg Asp Leu Glu Arg Ala Leu Tyr Leu Leu Val Arg Arg Val Leu His 
     370                375                380
Leu Gly Val Gln Met Leu Met Leu Ser Cys Gly Leu Gln Gln Met Gln 
 385                390                395                400
Asp Gly Glu Leu Thr Gln Gly Ser Leu Leu Ser Phe Met Ile Tyr Gln 
                 405                410                415
Glu Ser Val Gly Ser Tyr Val Gln Thr Leu Val Tyr Ile Tyr Gly Asp 
             420                425                430
Met Leu Ser Asn Val Gly Ala Ala Glu Lys Val Phe Ser Tyr Met Asp 
         435                440                445
Arg Gln Pro Asn Leu Pro Ser Pro Gly Thr Leu Ala Pro Thr Thr Leu 
     450                455                460
Gln Gly Val Val Lys Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn Arg 
 465                470                475                480
Pro Asp Arg Pro Val Leu Lys Gly Leu Thr Phe Thr Leu Arg Pro Gly 
                 485                490                495
Glu Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val 
             500                505                510
Ala Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly Gln Val Leu 
         515                520                525
Leu Asp Glu Lys Pro Ile Ser Gln Tyr Glu His Cys Tyr Leu His Ser 
     530                535                540
Gln Val Val Ser Val Gly Gln Glu Pro Val Leu Phe Ser Gly Ser Val 
 545                550                555                560
Arg Asn Asn Ile Ala Tyr Gly Leu Gln Ser Cys Glu Asp Asp Lys Val 
                 565                570                575
Met Ala Ala Ala Gln Ala Ala His Ala Asp Asp Phe Ile Gln Glu Met 
             580                585                590
Glu His Gly Ile Tyr Thr Asp Val Gly Glu Lys Gly Ser Gln Leu Ala 
         595                600                605
Ala Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg Ala Leu Val Arg Asp 
     610                615                620
Pro Arg Val Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Val Gln 
 625                630                635                640
Cys Glu Gln Ala Leu Gln Asp Trp Asn Ser Arg Gly Asp Arg Thr Val 
                 645                650                655
Leu Val Ile Ala His Arg Leu Gln Thr Val Gln Arg Ala His Gln Ile 
             660                665                670
Leu Val Leu Gln Glu Gly Lys Leu Gln Lys Leu Ala Gln Leu 
         675                680                685



<210> 9668
<211> 499
<212> DNA
<213> Rattus norvegicus
<308> X58200
<400> 9668

ctctttccg  acgctcaag  tgtcgaagc  aggacgtgg  gggtcctcc  gagcgaaat  60
ccggatttc  ctgggtctt  cggtaggag  tgtgatcaa  tgtgctgac  acacaggag  120
caaaaacct  tatatcatc  ctgtgaagg  aatcaaggg  cggctgaac  gacttcctg  180
tgctggtgt  ggcgacatg  tgatggcca  agttaagaa  ggcaaacca  aactaagga  240
aaaggtaca  cctgcagtg  tgattcgac  acgaaagtc  tatcgaaga  aagacgggg  300
gttccttta  tttgaagat  atgcagggg  catagtaaa  aataaaggc  agatgaaag  360
ttctgctat  acaggtcca  ttgcaaagg  gtgtgcaga  ttgtggccc  ggattgcat  420
caatgcagg  agcattgcc  gattctcca  tgtgtttgt  aaatatatt  attaaagtc  480
tctctctga  aaaaaaaaa  499



<210> 9669
<211> 140
<212> PRT
<213> Rattus norvegicus
<308> CAA41177
<400> 9669

Met Ser Lys Arg Gly Arg Gly Gly Ser Ser Gly Ala Lys Phe Arg Ile 
  1               5                  10                  15
Ser Leu Gly Leu Pro Val Gly Ala Val Ile Asn Cys Ala Asp Asn Thr 
             20                  25                  30
Gly Ala Lys Asn Leu Tyr Ile Ile Ser Val Lys Gly Ile Lys Gly Arg 
         35                  40                  45
Leu Asn Arg Leu Pro Ala Ala Gly Val Gly Asp Met Val Met Ala Thr 
     50                  55                  60
Val Lys Lys Gly Lys Pro Glu Leu Arg Lys Lys Val His Pro Ala Val 
 65                  70                  75                  80
Val Ile Arg Gln Arg Lys Ser Tyr Arg Arg Lys Asp Gly Val Phe Leu 
                 85                  90                  95
Tyr Phe Glu Asp Asn Ala Gly Val Ile Val Asn Asn Lys Gly Glu Met 
             100                105                110
Lys Gly Ser Ala Ile Thr Gly Pro Val Ala Lys Glu Cys Ala Asp Leu 
         115                120                125
Trp Pro Arg Ile Ala Ser Asn Ala Gly Ser Ile Ala 
     130                135                140



<210> 9670
<211> 493
<212> DNA
<213> Homo sapiens
<308> NM_000978
<400> 9670

cttttttct  ttttccggc  ttcaagatg  cgaagcgag  acgtggtgg  tcctctggt  60
cgaaattcc  gatttcctt  ggtcttccg  taggagctg  aatcaattg  gctgacaac  120
caggagcca  aaacctgta  atcatctcc  tgaagggga  caagggacg  ctgaacaga  180
ttcccgctg  tggtgtggg  gacatggtg  tggccacag  caagaaagg  aaaccagag  240
tcagaaaaa  ggtacatcc  gcagtggtc  ttcgacaac  aaagtcata  cgtagaaaa  300
atggcgtgt  tctttattt  gaagataat  caggagtca  agtgaacaa  aaaggcgag  360
tgaaaggtt  tgccattac  ggaccagta  caaaggagt  tgcagactt  tggccccgg  420
ttgcatcca  tgctggcag  attgcatga  tctccagta  atttgtaaa  aataaaaaa  480
aactaaacc  att  493



<210> 9671
<211> 140
<212> PRT
<213> Homo sapiens
<308> P23131
<400> 9671

Met Ser Lys Arg Gly Arg Gly Gly Ser Ser Gly Ala Lys Phe Arg Ile 
  1               5                  10                  15
Ser Leu Gly Leu Pro Val Gly Ala Val Ile Asn Cys Ala Asp Asn Thr 
             20                  25                  30
Gly Ala Lys Asn Leu Tyr Ile Ile Ser Val Lys Gly Ile Lys Gly Arg 
         35                  40                  45
Leu Asn Arg Leu Pro Ala Ala Gly Val Gly Asp Met Val Met Ala Thr 
     50                  55                  60
Val Lys Lys Gly Lys Pro Glu Leu Arg Lys Lys Val His Pro Ala Val 
 65                  70                  75                  80
Val Ile Arg Gln Arg Lys Ser Tyr Arg Arg Lys Asp Gly Val Phe Leu 
                 85                  90                  95
Tyr Phe Glu Asp Asn Ala Gly Val Ile Val Asn Asn Lys Gly Glu Met 
             100                105                110
Lys Gly Ser Ala Ile Thr Gly Pro Val Ala Lys Glu Cys Ala Asp Leu 
         115                120                125
Trp Pro Arg Ile Ala Ser Asn Ala Gly Ser Ile Ala 
     130                135                140



<210> 9672
<211> 499
<212> DNA
<213> Rattus norvegicus
<308> X58200
<400> 9672

ctctttccg  acgctcaag  tgtcgaagc  aggacgtgg  gggtcctcc  gagcgaaat  60
ccggatttc  ctgggtctt  cggtaggag  tgtgatcaa  tgtgctgac  acacaggag  120
caaaaacct  tatatcatc  ctgtgaagg  aatcaaggg  cggctgaac  gacttcctg  180
tgctggtgt  ggcgacatg  tgatggcca  agttaagaa  ggcaaacca  aactaagga  240
aaaggtaca  cctgcagtg  tgattcgac  acgaaagtc  tatcgaaga  aagacgggg  300
gttccttta  tttgaagat  atgcagggg  catagtaaa  aataaaggc  agatgaaag  360
ttctgctat  acaggtcca  ttgcaaagg  gtgtgcaga  ttgtggccc  ggattgcat  420
caatgcagg  agcattgcc  gattctcca  tgtgtttgt  aaatatatt  attaaagtc  480
tctctctga  aaaaaaaaa  499



<210> 9673
<211> 140
<212> PRT
<213> Rattus norvegicus
<308> CAA41177
<400> 9673

Met Ser Lys Arg Gly Arg Gly Gly Ser Ser Gly Ala Lys Phe Arg Ile 
  1               5                  10                  15
Ser Leu Gly Leu Pro Val Gly Ala Val Ile Asn Cys Ala Asp Asn Thr 
             20                  25                  30
Gly Ala Lys Asn Leu Tyr Ile Ile Ser Val Lys Gly Ile Lys Gly Arg 
         35                  40                  45
Leu Asn Arg Leu Pro Ala Ala Gly Val Gly Asp Met Val Met Ala Thr 
     50                  55                  60
Val Lys Lys Gly Lys Pro Glu Leu Arg Lys Lys Val His Pro Ala Val 
 65                  70                  75                  80
Val Ile Arg Gln Arg Lys Ser Tyr Arg Arg Lys Asp Gly Val Phe Leu 
                 85                  90                  95
Tyr Phe Glu Asp Asn Ala Gly Val Ile Val Asn Asn Lys Gly Glu Met 
             100                105                110
Lys Gly Ser Ala Ile Thr Gly Pro Val Ala Lys Glu Cys Ala Asp Leu 
         115                120                125
Trp Pro Arg Ile Ala Ser Asn Ala Gly Ser Ile Ala 
     130                135                140



<210> 9674
<211> 493
<212> DNA
<213> Homo sapiens
<308> NM_000978
<400> 9674

cttttttct  ttttccggc  ttcaagatg  cgaagcgag  acgtggtgg  tcctctggt  60
cgaaattcc  gatttcctt  ggtcttccg  taggagctg  aatcaattg  gctgacaac  120
caggagcca  aaacctgta  atcatctcc  tgaagggga  caagggacg  ctgaacaga  180
ttcccgctg  tggtgtggg  gacatggtg  tggccacag  caagaaagg  aaaccagag  240
tcagaaaaa  ggtacatcc  gcagtggtc  ttcgacaac  aaagtcata  cgtagaaaa  300
atggcgtgt  tctttattt  gaagataat  caggagtca  agtgaacaa  aaaggcgag  360
tgaaaggtt  tgccattac  ggaccagta  caaaggagt  tgcagactt  tggccccgg  420
ttgcatcca  tgctggcag  attgcatga  tctccagta  atttgtaaa  aataaaaaa  480
aactaaacc  att  493



<210> 9675
<211> 140
<212> PRT
<213> Homo sapiens
<308> P23131
<400> 9675

Met Ser Lys Arg Gly Arg Gly Gly Ser Ser Gly Ala Lys Phe Arg Ile 
  1               5                  10                  15
Ser Leu Gly Leu Pro Val Gly Ala Val Ile Asn Cys Ala Asp Asn Thr 
             20                  25                  30
Gly Ala Lys Asn Leu Tyr Ile Ile Ser Val Lys Gly Ile Lys Gly Arg 
         35                  40                  45
Leu Asn Arg Leu Pro Ala Ala Gly Val Gly Asp Met Val Met Ala Thr 
     50                  55                  60
Val Lys Lys Gly Lys Pro Glu Leu Arg Lys Lys Val His Pro Ala Val 
 65                  70                  75                  80
Val Ile Arg Gln Arg Lys Ser Tyr Arg Arg Lys Asp Gly Val Phe Leu 
                 85                  90                  95
Tyr Phe Glu Asp Asn Ala Gly Val Ile Val Asn Asn Lys Gly Glu Met 
             100                105                110
Lys Gly Ser Ala Ile Thr Gly Pro Val Ala Lys Glu Cys Ala Asp Leu 
         115                120                125
Trp Pro Arg Ile Ala Ser Asn Ala Gly Ser Ile Ala 
     130                135                140



<210> 9676
<211> 1459
<212> DNA
<213> Rattus norvegicus
<308> X58294
<400> 9676

gcgtgacta  gtcccacca  tggggatac  gcaagagca  cggaccaga  aactggcac  60
aggagttcc  cattgccaa  ggagaccga  agtcccctg  ggacattga  accgggact  120
cccagcatg  cccttccct  cagcctctg  tcatatgtt  cgataaggt  gcttccaag  180
gcattgtca  caatggcca  tccttcaac  ttgagtttg  tgactccca  gactttgca  240
tgctgaaag  gggacccct  agtggctcc  acagattga  ccagtttca  tttcactgg  300
gctcatctg  tggccaggg  tctgagcac  ccgtgaaca  aaaaaaata  gctgcagag  360
ttcacttgg  tcactggaa  accaaatat  gggattttg  aaaagctgt  cagcaccca  420
atggactgg  tgttttggg  atttttttg  agattggac  tgcctcaca  ggccttcag  480
aaatcactg  agcactgca  tccattaaa  caaagggga  acgtgcagc  tttgctaac  540
ttgatcctt  ctcccttct  cctggaaac  tggactact  gacatatcc  ggctctctg  600
ccactccgc  cctgctgga  tgtgtgacc  ggatagtgc  caaggaacc  attactgtc  660
gcagtgagc  gatgtctca  ttccgtaaa  tgaacttca  ttcggaggg  gaggctgaa  720
aactgatgg  ggacaactg  cgtccagct  agccgctga  gaacagaaa  atcaaggcg  780
cctttaaat  aaatgaccc  gcagctggg  tccaaaaag  acaagtgtg  ctgcctctc  840
gtagctaag  acagttccg  cttggtgat  cagatcccg  ctttgcatc  gatattgta  900
gccttttta  ctctcaccc  ttgtgctta  taataaaat  tgaaaagga  gacccaggt  960
tctcatgtg  tggtagcat  gtggcaggc  ggtggttga  ttagggcat  ctttctcag  1020
cacaacaat  caatgcaaa  aacagatat  gcctcttgc  tctccacag  catagaata  1080
tgagtactc  ggcctgttt  ttaaaatgc  atttttaaa  ccatataag  tagaatgat  1140
gtttacaaa  ccacatcat  agacaaact  aggcaattt  ggcaaatca  gtaaaacag  1200
catagtttt  tggttatta  ttagatgaa  gttcactat  ccaagatct  atattaaag  1260
aaaactttt  aaaagctta  atatttgta  caaagttat  cttaaatat  aattatgtt  1320
taacttagt  acttttgat  tctagaggt  taaatgaag  tgtaaaaat  gatatagtt  1380
tgatacaga  tatatttcc  ttcagataa  ttaccataa  ctaatggat  atgtatttt  1440
gatatattc  ctaataaaa  1459



<210> 9677
<211> 259
<212> PRT
<213> Rattus norvegicus
<308> P27139
<400> 9677

Ser His His Trp Gly Tyr Ser Lys Ser Asn Gly Pro Glu Asn Trp His 
  1               5                  10                  15
Lys Glu Phe Pro Ile Ala Asn Gly Asp Arg Gln Ser Pro Val Asp Ile 
             20                  25                  30
Asp Thr Gly Thr Ala Gln His Asp Pro Ser Leu Gln Pro Leu Leu Ile 
         35                  40                  45
Cys Tyr Asp Lys Val Ala Ser Lys Ser Ile Val Asn Asn Gly His Ser 
     50                  55                  60
Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Phe Ala Val Leu Lys Glu 
 65                  70                  75                  80
Gly Pro Leu Ser Gly Ser Tyr Arg Leu Ile Gln Phe His Phe His Trp 
                 85                  90                  95
Gly Ser Ser Asp Gly Gln Gly Ser Glu His Thr Val Asn Lys Lys Lys 
             100                105                110
Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly Asp 
         115                120                125
Phe Gly Lys Ala Val Gln His Pro Asp Gly Leu Ala Val Leu Gly Ile 
     130                135                140
Phe Leu Lys Ile Gly Pro Ala Ser Gln Gly Leu Gln Lys Ile Thr Glu 
 145                150                155                160
Ala Leu His Ser Ile Lys Thr Lys Gly Lys Arg Ala Ala Phe Ala Asn 
                 165                170                175
Phe Asp Pro Cys Ser Leu Leu Pro Gly Asn Leu Asp Tyr Trp Thr Tyr 
             180                185                190
Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp Ile 
         195                200                205
Val Leu Lys Glu Pro Ile Thr Val Ser Ser Glu Gln Met Ser His Phe 
     210                215                220
Arg Lys Leu Asn Phe Asn Ser Glu Gly Glu Ala Glu Glu Leu Met Val 
 225                230                235                240
Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Lys Ile Lys Ala 
                 245                250                255
Ser Phe Lys 
             260



<210> 9678
<211> 1551
<212> DNA
<213> Homo sapiens
<308> J03037
<400> 9678

ggcgcccaa  ccgccgccg  cagatcggt  ccgattcct  ccctgcccc  accgccagc  60
cgaccatgt  ccatcactg  gggtacggc  aacacaacg  acctgagca  tggcataag  120
acttcccca  tgccaaggg  gagcgccag  cccctgttg  catcgacac  catacagcc  180
agtatgacc  ttccctgaa  cccctgtct  tttcctatg  tcaagcaac  tccctgagg  240
tcctcaaca  tggtcatgc  ttcaacgtg  agtttgatg  ctctcagga  aaagcagtg  300
tcaagggag  acccctgga  ggcacttac  gattgattc  gtttcactt  cactggggt  360
cacttgatg  acaaggttc  gagcatact  tggataaaa  gaaatatgc  gcagaactt  420
acttggttc  ctggaacac  aaatatggg  attttggga  agctgtgca  caacctgat  480
gactggccg  tctaggtat  tttttgaag  ttggcagcg  taaaccggg  cttcagaaa  540
ttgttgatg  gctggattc  attaaaaca  agggcaaga  tgctgactt  actaacttc  600
atcctcgtg  cctccttcc  gaatccctg  attactgga  ctacccagg  tcactgacc  660
cccctcctc  tctggaatg  gtgacctgg  ttgtgctca  ggaacccat  agcgtcagc  720
gcgagcagg  gttgaaatt  cgtaaactt  acttcaatg  ggagggtga  cccgaagaa  780
tgatggtgg  caactggcg  ccagctcag  cactgaaga  caggcaaat  aaagcttcc  840
tcaaataag  tggtcccat  gtctgtatc  aaataatga  tcttcgggt  tttcccttt  900
gctaagcac  gatctacct  ggtgatttg  accctggtt  ctttgtgtc  agttttcta  960
acccttcat  tcttacttg  tagacttac  aataaaatg  gaagactag  ccaattgtc  1020
tgcttgaca  aactgctgt  gctggttgg  gctttgttt  tggtagtag  ttttctgta  1080
cacagaata  aggataaga  ataagaata  agtaccttg  ctttgttca  agcatgtag  1140
gtgatgagc  ctcacaatt  ttgactaaa  tgctgcttt  aaaacatag  aaagtagaa  1200
ggttgagtg  aaatccata  cacaagata  attgagcta  ttaaggcaa  tcaggtaaa  1260
tagtcatga  tctatgtaa  gtaaaccag  aaaaataaa  gttcatgat  tcaagatgt  1320
atattaaag  aaaacttta  aaattatta  atatttata  caaagttat  ttaaatatg  1380
attctgttg  aatttaatg  cttttgaat  acagagata  aaatgaagt  ttatctgta  1440
aaattgtta  aattagagt  gtgatacag  gtatatttc  attcagaca  tatatcata  1500
cttaataaa  attgtattt  agatatatt  tctaataaa  ttcagaatt  t  1551



<210> 9679
<211> 259
<212> PRT
<213> Homo sapiens
<308> P00918
<400> 9679

Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp His 
  1               5                  10                  15
Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp Ile 
             20                  25                  30
Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser Val 
         35                  40                  45
Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His Ala 
     50                  55                  60
Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys Gly 
 65                  70                  75                  80
Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His Trp 
                 85                  90                  95
Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys Lys 
             100                105                110
Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly Asp 
         115                120                125
Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly Ile 
     130                135                140
Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val Asp 
 145                150                155                160
Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr Asn 
                 165                170                175
Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr Tyr 
             180                185                190
Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp Ile 
         195                200                205
Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys Phe 
     210                215                220
Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met Val 
 225                230                235                240
Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys Ala 
                 245                250                255
Ser Phe Lys 
             260



<210> 9680
<211> 2125
<212> DNA
<213> Rattus norvegicus
<308> X58631
<400> 9680

cccgcagtg  ccccagaga  ctctaatgg  accaagtaa  agaccggcc  tcctgtagc  60
cggggacgc  agatctcag  agatgtcgg  tatacaggc  tcctggcca  ccggtacag  120
atgtattgc  aagtacaac  tccatggca  tgccgagca  gaccttccc  tctgcaaag  180
agatgtgct  accattgtg  ctgtcacca  ggaccccaa  tggtacaaa  ccaaaaaca  240
agtgggccg  gagggcatc  tcccagcca  ctatgtcca  aagcgtgag  gtgtgaagg  300
aggcaccaa  ctcagcctt  tgccctggt  ccacggcaa  atcacacgg  agcaggcgg  360
gcggcttct  tacccacca  agacaggcc  gttcctggt  cgggaaagc  ccaactacc  420
tggggacta  acactgtgt  tgagctgtg  aggcaaggt  gagcactac  gcatcatgt  480
tcacgcgag  aagctgagc  ttgatgagg  ggtgtactt  gagaacctc  tgcagctgg  540
ggagcacta  accacagat  ccgacggac  ctgcactcg  ctcatcaaa  caaaggtca  600
ggagggcac  gtggcggcc  aagatgaat  ctaccgcag  ggctgggcc  tgaacatga  660
ggaactgaa  ctgctacag  caataggaa  gggggagtt  ggagatgtg  tgctggggg  720
ttaccgagg  aacaaagtt  cagtcaagt  cattaagaa  gatgctaca  cccaggcct  780
cctggctga  gcctctgtc  tgacgcagc  tcggcacag  aacctagtc  agctactgg  840
tgtgattgt  gaggagaag  gtgggctct  catcgtcac  gagtacatg  ccaagggga  900
tttggtgga  tatcttcga  cacgtggtc  ttcggtgct  ggcggagac  gtctcctca  960
attctcact  gacgtctgt  aagccatgg  gtacctgga  ggtaacaat  ttgtgcacc  1020
ggacttggc  gcccggaat  tgctggtgt  tgaggacaa  gtggccaaa  tcagtgact  1080
tggcctcac  aaggaagct  ccagcactc  ggacacagg  aaactgcca  tcaagtgga  1140
agctcctga  gccttgaga  agaagaaat  ttccaccaa  tctgatgtg  ggagtttcg  1200
aatccttct  tgggaaatc  attccttcg  gcgagtgcc  tacccaaga  ttcccctga  1260
ggacgtcgt  cctcgggtg  aaaagggct  taagatgga  gctccggat  gctgcccac  1320
cgcagtcta  gatgttatg  agaactgct  gcacctgga  gctgccacg  ggcccacct  1380
tctgcagct  cgagagcag  tcgagcaca  cagaaccca  gagctgcac  tgtgacctc  1440
gcctccacc  aggccatgg  cttgcaggg  tggggccta  aagatacag  tttggtgcc  1500
tgctgcttg  tgggcctga  cttgaactg  gccccagcg  gctggtagg  ttcttgcct  1560
tgacctgcc  gtcccttct  gccccccag  gaccccacc  aggcctggc  tcttctctc  1620
tggacccac  tatagggct  agggcgccc  ctgaagggg  tgagaagag  ggaggccga  1680
gagcgggag  cagtgctcc  gtggtcggc  ttctctcgg  cccatcatt  gccttctta  1740
agttttatt  ctttccttt  ttgagattt  tttccgtgt  tttattttt  attattttt  1800
aacataagg  gaaagaaag  acccagcaa  tgggcattt  acaagaagt  cgaatctta  1860
ttttcctgt  ctgcccctg  gggtgggga  gaatcagcc  ctctctagg  acccatcac  1920
ccagcctgt  ccccatcct  tgttccatg  ccagtgttg  ctcggtcgc  tatgtttgc  1980
cttgaccat  tgcgctgtt  gcatgtgcc  aaggcaggc  tctgtcagg  gcttggatt  2040
catgtgctg  ggccgctca  ccacactgc  ttgtgagat  gaatcgtaa  aaaccactc  2100
atgaggaca  cgccaaaaa  aaaaa  2125



<210> 9681
<211> 450
<212> PRT
<213> Rattus norvegicus
<308> CAA41484
<400> 9681

Met Ser Ala Ile Gln Ala Ser Trp Pro Ser Gly Thr Glu Cys Ile Ala 
  1               5                  10                  15
Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
             20                  25                  30
Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
         35                  40                  45
Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
     50                  55                  60
Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
 65                  70                  75                  80
Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                 85                  90                  95
Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
             100                105                110
Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Glu Gly Lys Val Glu His 
         115                120                125
Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
     130                135                140
Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Thr Asp Ala 
 145                150                155                160
Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                 165                170                175
Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
             180                185                190
Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
         195                200                205
Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
     210                215                220
Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
 225                230                235                240
Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                 245                250                255
Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
             260                265                270
Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
         275                280                285
Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
     290                295                300
Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
 305                310                315                320
Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                 325                330                335
Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
             340                345                350
Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
         355                360                365
Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
     370                375                380
Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
 385                390                395                400
Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                 405                410                415
Asp Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Thr Arg Pro Thr 
             420                425                430
Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Arg Thr His Glu Leu 
         435                440                445
His Leu 
     450



<210> 9682
<211> 2420
<212> DNA
<213> Homo sapiens
<308> NM_004383
<400> 9682

tccggggcg  cccccggca  ccagcgcga  gttccaaaa  cgaacctca  tggcggcgc  60
cggaagcgg  actctgccg  ggccgcgcc  gctacattg  ttcctcccc  cgactccct  120
ccgccccct  cccccgcct  tcttccctc  gcgacccgg  ccgtgcgtc  gtccccctg  180
ctctgcctg  cggtccctc  tcccctctc  ttgcaccca  acctctttg  accgcaccc  240
ctggggacc  ctgcgcccc  cccctcccc  ctgaccgca  ggaccgtcc  gcaggccgc  300
gatgccgcc  gcggcgagg  ggcccggac  gcagtgccc  aagagagct  taatggtac  360
aagtgacag  ttggcttta  tgtgactcg  ggacgccag  gctcctgag  agatgtcag  420
aatacaggc  gcctggcca  ccggtacag  atgtattgc  aagtacaac  tccacggca  480
tgccgagca  gacctgccc  tctgcaaag  agacgtgct  accattgtg  ccgtcacca  540
ggaccccaa  tggtacaaa  ccaaaaaca  ggtgggccg  gagggcatc  tcccagcca  600
ctacgtcca  aagcgggag  gcgtgaagg  gggtaccaa  ctcagcctc  tgccttggt  660
ccacggcaa  atcacacgg  agcaggctg  gcggcttct  tacccgccg  agacaggcc  720
gttcctggt  cgggagagc  ccaactacc  cggagacta  acgctgtgc  tgagctgcg  780
cggcaaggt  gagcactac  gcatcatgt  ccatgccag  aagctcagc  tcgacgagg  840
ggtgtactt  gagaacctc  tgcagctgg  ggagcacta  acctcagac  cagatggac  900
ctgtacgcg  ctcattaaa  caaaggtca  ggagggcac  gtggcggcc  aggatgagt  960
ctaccgcag  ggctgggcc  tgaacatga  ggagctgaa  ctgctgcag  ccatcggga  1020
gggggagtt  ggagacgtg  tgctgggcg  ttaccgagg  aacaaagtc  ccgtcaagt  1080
cattaagaa  gacgccact  cccaggcct  cctggctga  gcctcagtc  tgacgcaac  1140
gcggcatag  aacctggtg  agctcctgg  cgtgatcgt  gaggagaag  gcgggctct  1200
catcgtcac  gagtacatg  ccaagggga  ccttgtgga  tacctgcgg  ctaggggtc  1260
gtcagtgct  ggcggagac  gtctcctca  gttctcgct  gatgtctgc  aggccatgg  1320
atacctgga  ggcaacaat  tcgtgcatc  agacctggc  gcccgcaat  tgctggtgt  1380
tgaggacaa  gtggccaag  tcagcgact  tggtctcac  aaggaggcg  ccagcaccc  1440
ggacacggg  aagctgcca  tcaagtgga  agcccctga  gccctgaga  agaagaaat  1500
ctccactaa  tctgacgtg  ggagtttcg  aatccttct  tgggaaatc  actcctttg  1560
gcgagtgcc  tatccaaga  ttcccctga  ggacgtcgt  cctcgggtg  agaagggct  1620
caagatgga  gcccccgac  gctgcccgc  cgcagtcta  gaagtcatg  agaactgct  1680
gcacctgga  gccgccatg  ggccctcct  cctacagct  cgagagcag  ttgagcaca  1740
caaaaccca  gagctgcac  tgtgacggc  ggcctccgc  tgggtcatg  gcctgtggg  1800
actgaacct  gaagatcat  gacctggtg  ccctgctca  tgggcccga  cctgaactg  1860
gccccagcg  gctggcggg  ctttttcct  cgtcccagc  tgcacccct  cggccccgt  1920
tctcttgga  ccacctgtg  ggcctgggg  gcccactga  gggccaggg  ggaaggagg  1980
cacggagcg  gcggcagcg  cccaccacg  cgggcttcc  tggcctccc  ccactcgcc  2040
tcttagagt  ttattcctt  ccttttttg  gattttttt  ccgtgtgtt  attttttat  2100
atttttcaa  ataaggaga  agaaagtac  cagcaaatg  gcattttac  agaagtacg  2160
atcttattt  tcctgtcct  cccgtgagg  gggggggac  gggcccctc  ctagggacc  2220
ctcgcccca  cctcattcc  cattctgtg  cccatgtcc  gtgtctcct  ggtcgcccc  2280
tgtttgcgc  tgaccatgt  gcactgttt  catgcgccc  aggcagacg  ctgtcaggg  2340
cttggattt  gtgtgccgc  gccacccgc  cacccgcct  gtgagatgg  atcgtaata  2400
accacgcca  gaggaaaaaa  2420



<210> 9683
<211> 450
<212> PRT
<213> Homo sapiens
<308> P41240
<400> 9683

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
  1               5                  10                  15
Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
             20                  25                  30
Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
         35                  40                  45
Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
     50                  55                  60
Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
 65                  70                  75                  80
Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                 85                  90                  95
Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
             100                105                110
Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
         115                120                125
Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
     130                135                140
Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
 145                150                155                160
Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                 165                170                175
Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
             180                185                190
Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
         195                200                205
Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
     210                215                220
Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
 225                230                235                240
Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                 245                250                255
Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
             260                265                270
Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
         275                280                285
Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
     290                295                300
Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
 305                310                315                320
Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                 325                330                335
Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
             340                345                350
Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
         355                360                365
Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
     370                375                380
Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
 385                390                395                400
Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                 405                410                415
Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
             420                425                430
Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
         435                440                445
His Leu 
     450



<210> 9684
<211> 1241
<212> DNA
<213> Rattus norvegicus
<308> X58830
<400> 9684

gaattcgac  tcacagcaa  tagcaatct  tgggtggtg  caccgcagc  caacatggg  60
ctccagctg  gtgtggtga  tcgggacgg  ctccacatc  acccccgtg  ggcgggcct  120
gtgggcaga  acggccctt  cgacaagca  cccttcatg  tggccttct  caaggtgag  180
gaggtccac  tgcgcacca  caggtcagc  tccagtcgg  gtcgacagc  gagtcgcaa  240
cggtccacc  agtcgcagg  cgtgtcccg  ggctccagt  cttcagact  caacagcag  300
gagttaaaa  cagcttgca  gaagcatga  ctttacgtg  gcttccagg  cctgggatg  360
caggactgg  tcatcgctc  caaaggcta  gctgccaac  attgtgacg  agagtgttc  420
ttccctctc  atgcacaca  gaatgccac  aaccacgcc  ttgtacaga  cttggtcca  480
cttatgaat  ccgagtacg  ccccaaacc  tgctgcgca  caaccaaac  gaatgccat  540
tcggttctt  acttcgacg  caactccaa  gtcatcttg  aaaaataca  gaacatggt  600
gtgagagct  gtggatgtc  ttgagtgga  gccagttgc  ggggctgtg  ttctgcctc  660
gattcctaa  atctgcctt  aaacacggg  agcagcaca  tgcagcggg  gcatgacac  720
caaagcatc  cctgctggt  ccttagccc  aggaggatt  tacgaggac  ttgtcgatg  780
ctttcccag  tgagcagtt  ctggtctgt  ggaagctgt  atgcttgta  cacaggcct  840
gaaactaca  aaacatagt  ttctcctcc  ccagtccca  ccagactag  cttagcttt  900
agatctagc  gtttgtggt  taagtagga  ataaacttg  aggaatatt  aatatccct  960
gttgaaaga  agatctagt  gttctacag  acccatccc  gggagattt  gcagatagc  1020
gaatggagg  gaggagaac  ctctattag  ttccattcc  agcaaaggg  agctcccac  1080
gaacctgca  cctggccat  acagggctt  gtggaggtg  cttctgtct  ctgttagtt  1140
cccgtttta  gttgactct  ggtggtgtg  aaatgtact  atttcggtc  aaacaaact  1200
tagcattcc  acgccatac  cctccctta  tcacagaat  c  1241



<210> 9685
<211> 207
<212> PRT
<213> Rattus norvegicus
<308> Q04906
<400> 9685

Glu Phe Asp Ile Thr Ala Thr Ser Asn Leu Trp Val Val Thr Pro Gln 
  1               5                  10                  15
His Asn Met Gly Leu Gln Leu Ser Val Val Thr Arg Asp Gly Leu His 
             20                  25                  30
Ile Asn Pro Arg Ala Ala Gly Leu Val Gly Arg Asp Gly Pro Tyr Asp 
         35                  40                  45
Lys Gln Pro Phe Met Val Ala Phe Phe Lys Val Ser Glu Val His Val 
     50                  55                  60
Arg Thr Thr Arg Ser Ala Ser Ser Arg Arg Arg Gln Gln Ser Arg Asn 
 65                  70                  75                  80
Arg Ser Thr Gln Ser Gln Asp Val Ser Arg Gly Ser Ser Ala Ser Asp 
                 85                  90                  95
Tyr Asn Ser Ser Glu Leu Lys Thr Ala Cys Lys Lys His Glu Leu Tyr 
             100                105                110
Val Ser Phe Gln Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Lys 
         115                120                125
Gly Tyr Ala Ala Asn Tyr Cys Asp Gly Glu Cys Ser Phe Pro Leu Asn 
     130                135                140
Ala His Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His 
 145                150                155                160
Leu Met Asn Pro Glu Tyr Val Pro Lys Pro Cys Cys Ala Pro Thr Lys 
                 165                170                175
Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Asn Ser Asn Val Ile 
             180                185                190
Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
         195                200                205



<210> 9686
<211> 509
<212> DNA
<213> Homo sapiens
<308> AI367148
<400> 9686

actgtctgt  tgaggcaga  gataacagc  gcatctcga  cagcctctg  cttaaagga  60
atctttatt  atcacgtat  gttcacaga  aattctttt  ttaaaaaaa  ccaacctcc  120
agagaagca  aactgtcaa  agtcttgta  acacaactt  agctttgca  cacgagtct  180
gtattccaa  aaaatcaaa  tggtacaat  tgtttgttt  cactatgat  ctttctaaa  240
aaacttttt  tttaaaagt  tggtctttc  ttcaatgtt  cagcaaaac  gatataaaa  300
agacaataa  ttatagttt  tatttacaa  aaaagctgt  agtgcaaac  gttgtagat  360
ataaatgta  tatttaatc  gtttagtat  aaattgcct  cccagtaca  gattgtgaa  420
aagacattt  gaaaatatt  taaaattta  tctgagcct  actttctac  agggaaatc  480
tgatttccg  tcataaaca  catgctcat  509



<210> 9687
<211> 513
<212> PRT
<213> Homo sapiens
<308> P22004
<400> 9687

Met Pro Gly Leu Gly Arg Arg Ala Gln Trp Leu Cys Trp Trp Trp Gly 
  1               5                  10                  15
Leu Leu Cys Ser Cys Cys Gly Pro Pro Pro Leu Arg Pro Pro Leu Pro 
             20                  25                  30
Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Leu Leu Gly Asp Gly Gly 
         35                  40                  45
Ser Pro Gly Arg Thr Glu Gln Pro Pro Pro Ser Pro Gln Ser Ser Ser 
     50                  55                  60
Gly Phe Leu Tyr Arg Arg Leu Lys Thr Gln Glu Lys Arg Glu Met Gln 
 65                  70                  75                  80
Lys Glu Ile Leu Ser Val Leu Gly Leu Pro His Arg Pro Arg Pro Leu 
                 85                  90                  95
His Gly Leu Gln Gln Pro Gln Pro Pro Ala Leu Arg Gln Gln Glu Glu 
             100                105                110
Gln Gln Gln Gln Gln Gln Leu Pro Arg Gly Glu Pro Pro Pro Gly Arg 
         115                120                125
Leu Lys Ser Ala Pro Leu Phe Met Leu Asp Leu Tyr Asn Ala Leu Ser 
     130                135                140
Ala Asp Asn Asp Glu Asp Gly Ala Ser Glu Gly Glu Arg Gln Gln Ser 
 145                150                155                160
Trp Pro His Glu Ala Ala Ser Ser Ser Gln Arg Arg Gln Pro Pro Pro 
                 165                170                175
Gly Ala Ala His Pro Leu Asn Arg Lys Ser Leu Leu Ala Pro Gly Ser 
             180                185                190
Gly Ser Gly Gly Ala Ser Pro Leu Thr Ser Ala Gln Asp Ser Ala Phe 
         195                200                205
Leu Asn Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu Tyr 
     210                215                220
Asp Lys Glu Phe Ser Pro Arg Gln Arg His His Lys Glu Phe Lys Phe 
 225                230                235                240
Asn Leu Ser Gln Ile Pro Glu Gly Glu Val Val Thr Ala Ala Glu Phe 
                 245                250                255
Arg Ile Tyr Lys Asp Cys Val Met Gly Ser Phe Lys Asn Gln Thr Phe 
             260                265                270
Leu Ile Ser Ile Tyr Gln Val Leu Gln Glu His Gln His Arg Asp Ser 
         275                280                285
Asp Leu Phe Leu Leu Asp Thr Arg Val Val Trp Ala Ser Glu Glu Gly 
     290                295                300
Trp Leu Glu Phe Asp Ile Thr Ala Thr Ser Asn Leu Trp Val Val Thr 
 305                310                315                320
Pro Gln His Asn Met Gly Leu Gln Leu Ser Val Val Thr Arg Asp Gly 
                 325                330                335
Val His Val His Pro Arg Ala Ala Gly Leu Val Gly Arg Asp Gly Pro 
             340                345                350
Tyr Asp Lys Gln Pro Phe Met Val Ala Phe Phe Lys Val Ser Glu Val 
         355                360                365
His Val Arg Thr Thr Arg Ser Ala Ser Ser Arg Arg Arg Gln Gln Ser 
     370                375                380
Arg Asn Arg Ser Thr Gln Ser Gln Asp Val Ala Arg Val Ser Ser Ala 
 385                390                395                400
Ser Asp Tyr Asn Ser Ser Glu Leu Lys Thr Ala Cys Arg Lys His Glu 
                 405                410                415
Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala 
             420                425                430
Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly Glu Cys Ser Phe Pro 
         435                440                445
Leu Asn Ala His Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu 
     450                455                460
Val His Leu Met Asn Pro Glu Tyr Val Pro Lys Pro Cys Cys Ala Pro 
 465                470                475                480
Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Asn Ser Asn 
                 485                490                495
Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys 
             500                505                510
His 
         515



<210> 9688
<211> 2770
<212> DNA
<213> Rattus norvegicus
<308> X58865
<400> 9688

ggcgacagc  gcgcggaac  cagagcggc  ggagaggag  tcgggctcc  ggtctctgc  60
gccgtcatg  ctaccgtgg  cctggagaa  ttgcggatg  cgggggctg  caaggccat  120
ggagtgctg  caagcggcg  tgacgcgca  ggtatgaat  ctgctgtca  ggctgtgac  180
cgtatgggc  tatatgtgg  ggccaaagt  ttcctcatc  acgagggct  cgagggcct  240
gtggaagga  gcgagaaca  caagccagc  aactggctc  gtgtctcca  catcatcca  300
ctgggcggc  ccatcattg  cagtgcccg  tgtaaggcc  tcactacga  ggaagggcg  360
ctggcagcg  cctacaatc  gctccaaca  ggcatcacc  acctgtgtg  catcggtgg  420
gatggcagc  tcacggggg  caacatctt  cgcaacgag  ggggcagct  gctggagga  480
ctggtgaag  aaggcaaga  ctcagagtc  acagctcag  actacgcac  cttgagcat  540
gccggtctg  tgggctcca  cgacaacga  ttctgcggc  ccgacatga  catcggcac  600
gactcggcc  tgcaccgga  catggaggt  atcgacgcc  tcaccacca  tgcccagag  660
caccagagg  cctttgtgt  ggaggtgat  ggacggcac  gcgggtacc  ggcgctggt  720
tctgcgctg  cctccgggg  tgattggct  ttcatccct  aagcgcccc  ggaggatgg  780
tgggagaac  tcatgtgtg  gaggctggg  gagactcgg  gccgggggt  tcgactgaa  840
atcatcatc  tcgcggagg  tgccatcga  cggcatgga  agcctatct  atccagcta  900
gtgaaagac  tggtggttc  gaggctggg  ttcgataca  gagtgaccg  gctgggcca  960
gtacagcga  gagggacac  ctcggcctt  gaccgagtc  tgagtagca  gatgggtat  1020
gaggccgtg  tggcgctgc  ggaggccac  ccggacacg  cggcctgcg  ggtcagcct  1080
tccgggaat  agtctgtgc  gctgcctct  atggagtgt  tgcaagtga  gaaggatgt  1140
cagaaggcc  tggatgaga  gaggtttga  gaggccatc  agctccgtg  caggagctt  1200
gagaacaac  ggaaaattt  caagctcct  gcccaccag  aggtgtcta  ggagaagtc  1260
aacttctcc  tggccatcc  gaatgtggg  gctccagcg  ccggcatga  cgcagccgt  1320
cgctccgcg  tacgcactg  catctccga  ggacacaca  tgtacgttg  gcatgatgg  1380
tttgagggc  tggccaagg  tcaggtgca  gaagtgggc  ggcatgatg  ggcaggttg  1440
ctaggacgt  gtggctcaa  gctggggac  aagaggacc  tgcccaagc  ccacctgga  1500
gccattgta  aaaatctcc  tacctacaa  attcatgcc  tgttggtga  cggtggctt  1560
gaggcctac  agggtgtgc  gcagctggt  gaggctagg  ggcgctacg  ggaactctg  1620
atcgtcatg  gcgtcatcc  agccaccat  agcaacaat  tccctggca  tgacttcag  1680
ctgggctcg  acacggccg  caacgctgc  atggagagt  gtgaccgca  caaacaatc  1740
gcctcgggg  caaagcggc  tgtgttcat  gtagagacc  tggggggct  ctgtggcta  1800
ctggccact  tgacaggca  tgctgtggg  gccgatgcc  cctacgtct  tgaggaccc  1860
ttcaacatc  acgacttga  ggccaatgt  gagcatatg  cagagaaga  gaagacaga  1920
atccagagg  gcctggtgc  ccggaacga  aagtgtcac  aacactaca  cacggaatt  1980
ctatacaac  tatactcct  ggaaggcag  ggtgtgttc  actgcagga  caacgtgct  2040
ggccacctg  agcagggtg  cgctccaac  cccttcgac  ggaactatg  gaccaaact  2100
ggggtgaag  ccatgttgt  gatgtcgga  aagctgcgt  atgtctacc  caaagggcg  2160
gtgtttgcc  atgctccgg  ctcagcctg  gtgatcggc  tgaggaaga  ggtggtggc  2220
ttcagttcg  tcacagaac  caagaaaga  acagatttt  agcaccgta  gccgcggga  2280
cagtggtgg  tgaatctgc  gctgatgct  aagatgttg  cacactacc  catcagcat  2340
gccgactac  tgtctgggg  gctggagca  gtcacacgc  gcaccttga  catagacaa  2400
ggtttctga  cttaccgat  accctcgtt  ctgctctcc  ggactctct  tccctccca  2460
tgctagcca  agatcccag  actaagggg  actcacatg  aactcggag  ctgtggttg  2520
ttgaaggat  tgggggtct  ctgtgctgc  ctgggactc  tcccttagc  acccccacc  2580
ccccacccc  tcagaacag  gcacctgtg  ggcccttac  ttccagttc  ggctgggca  2640
acccacatc  ccactccct  actggtcag  tggctgcct  accacacgg  cgaaaagag  2700
ctcatggtt  tttttttta  aaataaagt  acctgttta  aaaaaaaaa  aaaaaaaaa  2760
aaaaaaaaaa  2770



<210> 9689
<211> 780
<212> PRT
<213> Rattus norvegicus
<308> P30835
<400> 9689

Met Ala Thr Val Asp Leu Glu Lys Leu Arg Met Ser Gly Ala Gly Lys 
  1               5                  10                  15
Ala Ile Gly Val Leu Thr Ser Gly Gly Asp Ala Gln Gly Met Asn Ala 
             20                  25                  30
Ala Val Arg Ala Val Thr Arg Met Gly Ile Tyr Val Gly Ala Lys Val 
         35                  40                  45
Phe Leu Ile Tyr Glu Gly Tyr Glu Gly Leu Val Glu Gly Gly Glu Asn 
     50                  55                  60
Ile Lys Pro Ala Asn Trp Leu Ser Val Ser Asn Ile Ile Gln Leu Gly 
 65                  70                  75                  80
Gly Thr Ile Ile Gly Ser Ala Arg Cys Lys Ala Phe Thr Thr Arg Glu 
                 85                  90                  95
Gly Arg Leu Ala Ala Ala Tyr Asn Leu Leu Gln His Gly Ile Thr Asn 
             100                105                110
Leu Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala Asn Ile Phe 
         115                120                125
Arg Asn Glu Trp Gly Ser Leu Leu Glu Glu Leu Val Lys Glu Gly Lys 
     130                135                140
Ile Ser Glu Ser Thr Ala Gln Asn Tyr Ala His Leu Ser Ile Ala Gly 
 145                150                155                160
Leu Val Gly Ser Ile Asp Asn Asp Phe Cys Gly Thr Asp Met Thr Ile 
                 165                170                175
Gly Thr Asp Ser Ala Leu His Arg Ile Met Glu Val Ile Asp Ala Ile 
             180                185                190
Thr Thr Thr Ala Gln Ser His Gln Arg Thr Phe Val Leu Glu Val Met 
         195                200                205
Gly Arg His Cys Gly Tyr Leu Ala Leu Val Ser Ala Leu Ala Ser Gly 
     210                215                220
Ala Asp Trp Leu Phe Ile Pro Glu Ala Pro Pro Glu Asp Gly Trp Glu 
 225                230                235                240
Asn Phe Met Cys Glu Arg Leu Gly Glu Thr Arg Ser Arg Gly Ser Arg 
                 245                250                255
Leu Asn Ile Ile Ile Ile Ala Glu Gly Ala Ile Asp Arg His Gly Lys 
             260                265                270
Pro Ile Ser Ser Ser Tyr Val Lys Asp Leu Val Val Gln Arg Leu Gly 
         275                280                285
Phe Asp Thr Arg Val Thr Val Leu Gly His Val Gln Arg Gly Gly Thr 
     290                295                300
Pro Ser Ala Phe Asp Arg Val Leu Ser Ser Lys Met Gly Met Glu Ala 
 305                310                315                320
Val Met Ala Leu Leu Glu Ala Thr Pro Asp Thr Pro Ala Cys Val Val 
                 325                330                335
Ser Leu Ser Gly Asn Gln Ser Val Arg Leu Pro Leu Met Glu Cys Val 
             340                345                350
Gln Val Thr Lys Asp Val Gln Lys Ala Met Asp Glu Lys Arg Phe Asp 
         355                360                365
Glu Ala Ile Gln Leu Arg Gly Arg Ser Phe Glu Asn Asn Trp Lys Ile 
     370                375                380
Tyr Lys Leu Leu Ala His Gln Lys Val Ser Lys Glu Lys Ser Asn Phe 
 385                390                395                400
Ser Leu Ala Ile Leu Asn Val Gly Ala Pro Ala Ala Gly Met Asn Ala 
                 405                410                415
Ala Val Arg Ser Ala Val Arg Thr Gly Ile Ser Glu Gly His Thr Val 
             420                425                430
Tyr Val Val His Asp Gly Phe Glu Gly Leu Ala Lys Gly Gln Val Gln 
         435                440                445
Glu Val Gly Trp His Asp Val Ala Gly Trp Leu Gly Arg Gly Gly Ser 
     450                455                460
Met Leu Gly Thr Lys Arg Thr Leu Pro Lys Pro His Leu Glu Ala Ile 
 465                470                475                480
Val Glu Asn Leu Arg Thr Tyr Asn Ile His Ala Leu Leu Val Ile Gly 
                 485                490                495
Gly Phe Glu Ala Tyr Glu Gly Val Leu Gln Leu Val Glu Ala Arg Gly 
             500                505                510
Arg Tyr Glu Glu Leu Cys Ile Val Met Cys Val Ile Pro Ala Thr Ile 
         515                520                525
Ser Asn Asn Val Pro Gly Thr Asp Phe Ser Leu Gly Ser Asp Thr Ala 
     530                535                540
Val Asn Ala Ala Met Glu Ser Cys Asp Arg Ile Lys Gln Ser Ala Ser 
 545                550                555                560
Gly Thr Lys Arg Arg Val Phe Ile Val Glu Thr Met Gly Gly Tyr Cys 
                 565                570                575
Gly Tyr Leu Ala Thr Val Thr Gly Ile Ala Val Gly Ala Asp Ala Ala 
             580                585                590
Tyr Val Phe Glu Asp Pro Phe Asn Ile His Asp Leu Lys Ala Asn Val 
         595                600                605
Glu His Met Thr Glu Lys Met Lys Thr Asp Ile Gln Arg Gly Leu Val 
     610                615                620
Leu Arg Asn Glu Lys Cys His Glu His Tyr Thr Thr Glu Phe Leu Tyr 
 625                630                635                640
Asn Leu Tyr Ser Ser Glu Gly Arg Gly Val Phe Asp Cys Arg Thr Asn 
                 645                650                655
Val Leu Gly His Leu Gln Gln Gly Gly Ala Pro Thr Pro Phe Asp Arg 
             660                665                670
Asn Tyr Gly Thr Lys Leu Gly Val Lys Ala Met Leu Trp Met Ser Glu 
         675                680                685
Lys Leu Arg Asp Val Tyr Arg Lys Gly Arg Val Phe Ala Asn Ala Pro 
     690                695                700
Asp Ser Ala Cys Val Ile Gly Leu Arg Lys Lys Val Val Ala Phe Ser 
 705                710                715                720
Ser Val Thr Glu Leu Lys Lys Glu Thr Asp Phe Glu His Arg Met Pro 
                 725                730                735
Arg Glu Gln Trp Trp Leu Asn Leu Arg Leu Met Leu Lys Met Leu Ala 
             740                745                750
His Tyr Arg Ile Ser Met Ala Asp Tyr Val Ser Gly Glu Leu Glu His 
         755                760                765
Val Thr Arg Arg Thr Leu Ser Ile Asp Lys Gly Phe 
     770                775                780



<210> 9690
<211> 2591
<212> DNA
<213> Homo sapiens
<308> D25328
<400> 9690

cccggacgt  cggctcccc  cggcctcct  gccatggac  cggacgact  ccgggcccc  60
aagggctcc  tgcggaagt  cctggagca  ctctccggg  ccggcaagg  catcggcgt  120
ctgaccagc  gcggggatg  tcaaggtat  aacgctgcc  tccgtgccg  ggtgcgcat  180
ggtatctac  tgggggcca  ggtgtactt  atctacgag  gctaccagg  catggtgga  240
ggaggctca  acatcgcag  ggccgactg  gagagtgtc  ccagcatcc  gcaagtggg  300
gggacgatc  ttggcagtg  gcggtgcca  gccttccgc  cgcgggaag  ccgcctgaa  360
gctgcttgc  acctgctgc  gcgcggcat  accaacctg  gtgtgatcg  cggggacgg  420
agcctcacc  gggccaacc  cttccggaa  gagtggagt  ggctgctgg  ggagctggc  480
aggaacggc  agatcgata  ggaggccgt  cagaagtac  cctacctca  cgtggtggg  540
atggtgggc  ccatcgaca  tgatttctg  ggcaccgac  tgaccatcg  cacggactc  600
gccctgcac  ggatcatcg  ggtcgtcga  gccatcatg  ccacggccc  gagccacca  660
aggaccttc  ttctggagg  gatgggacg  cactgtggg  acctggccc  ggtgagtgc  720
ttggcctgc  gtgcggact  ggtgttcct  ccagaatct  caccagagg  aggctggga  780
gagcagatg  gtgtcaaac  ctcggagaa  cgtgcccgg  aaaaaaggc  gaatattat  840
attgtggct  aaggagcaa  tgataccca  aataaaccc  tcacctctg  gaaaatcaa  900
gagcttgtc  tcacgcagc  gggctatga  acacgtgtg  ccatcctcg  gcacgtgca  960
agaggaggg  ccccttcgg  attcgacag  atcttggcc  gccgcatgg  agtggaggc  1020
gtcatcgcc  tgctagagg  caccccgga  accccagct  gcgtcgtgt  actgaacgg  1080
aaccacgcc  tgcgcctgc  gctgatgga  tgcgtgcag  tgactcagg  tgtgcagaa  1140
gcgatggac  agaggagat  tcaagatgc  gttcgactc  gagggagga  ctttgcggg  1200
aacctgaac  cctacaagc  acttgccat  aagctgccg  atgatcaga  cccaaagac  1260
aattgcaac  tagctgtca  caacgtggg  gcacccgcg  ctgggatga  cgcggccgt  1320
cgctcagct  tgcgcgtgg  cattgccga  ggccacagg  tgctcgcca  ctatgatgg  1380
tttgacggc  tcgccaagg  ccagatcaa  gaaatcggc  ggacagatg  cgggggctg  1440
accggccaa  gaggctcca  tcttgggac  aaacgcgtt  tcccgggga  gtacttgga  1500
gagatcgcc  cacagatgc  cacgcacag  atcaacgcg  tgctgatca  cggtggatt  1560
gaggcctac  tgggactcc  ggagctgtc  gccgcccgg  agaagcacg  ggagttctg  1620
gtccccatg  tcatggttc  cgctactgt  tccaacaat  tgccgggtt  cgatttcag  1680
atcggggca  acaccgccc  gaacactat  accgacacc  gcgaccgca  caagcagtc  1740
gccagcgga  ccaagcggc  cgtgttcat  atcgagacc  tgggcggct  ctgtggcta  1800
ctggccaac  tgggggggc  cgcggccgg  gctgatgcc  catacattt  cgaagagcc  1860
ttcgacatc  gggatctgc  gtccaacgt  gagcacctg  cggagaaaa  gaagaccac  1920
atccagaga  gccttgtgc  cagaaatga  agctgcagt  aaaactaca  caccgactt  1980
atttaccag  tgtattcag  agagggcaa  ggcgtgttt  actgcagga  gaacgtgct  2040
ggtcacatg  agcagggtg  ggcaccctc  ccatttgat  gaaactttg  aaccaaaat  2100
tctgccaga  ctatggagt  gatcactgc  aaactcaag  aggcccggg  cagaggaaa  2160
aaatttacc  ccgatgatt  catttgtgt  ctgggaata  gcaaaagaa  cgttatttt  2220
caacctgtg  cagagctga  gaagcaaac  gattttgag  acaggattc  caaagaaca  2280
tggtggctc  agctacggc  cctcatgaa  atcctggcc  agtacaagg  cagctatga  2340
gtgtcggac  caggccagc  ggaacatgt  cagccctgg  gtgtctgac  cagtcccgc  2400
tgcatgtgc  tgcagccac  gtggactgt  tgtttttgt  acacttaag  tattttatc  2460
gcactttat  cacgtatta  tgacattaa  acctaatcg  cgagtgccc  tctgcccca  2520
cagctccag  gcgtgctgt  tgtggagtg  gtctcatgc  ttcagatgt  catatgagc  2580
gaattaatt  a  2591



<210> 9691
<211> 784
<212> PRT
<213> Homo sapiens
<308> Q01813
<400> 9691

Met Asp Ala Asp Asp Ser Arg Ala Pro Lys Gly Ser Leu Arg Lys Phe 
  1               5                  10                  15
Leu Glu His Leu Ser Gly Ala Gly Lys Ala Ile Gly Val Leu Thr Ser 
             20                  25                  30
Gly Gly Asp Ala Gln Gly Met Asn Ala Ala Val Arg Ala Val Val Arg 
         35                  40                  45
Met Gly Ile Tyr Val Gly Ala Lys Val Tyr Phe Ile Tyr Glu Gly Tyr 
     50                  55                  60
Gln Gly Met Val Asp Gly Gly Ser Asn Ile Ala Glu Ala Asp Trp Glu 
 65                  70                  75                  80
Ser Val Ser Ser Ile Leu Gln Val Gly Gly Thr Ile Ile Gly Ser Ala 
                 85                  90                  95
Arg Cys Gln Ala Phe Arg Thr Arg Glu Gly Arg Leu Lys Ala Ala Cys 
             100                105                110
Asn Leu Leu Gln Arg Gly Ile Thr Asn Leu Cys Val Ile Gly Gly Asp 
         115                120                125
Gly Ser Leu Thr Gly Ala Asn Leu Phe Arg Lys Glu Trp Ser Gly Leu 
     130                135                140
Leu Glu Glu Leu Ala Arg Asn Gly Gln Ile Asp Lys Glu Ala Val Gln 
 145                150                155                160
Lys Tyr Ala Tyr Leu Asn Val Val Gly Met Val Gly Ser Ile Asp Asn 
                 165                170                175
Asp Phe Cys Gly Thr Asp Met Thr Ile Gly Thr Asp Ser Ala Leu His 
             180                185                190
Arg Ile Ile Glu Val Val Asp Ala Ile Met Thr Thr Ala Gln Ser His 
         195                200                205
Gln Arg Thr Phe Val Leu Glu Val Met Gly Arg His Cys Gly Tyr Leu 
     210                215                220
Ala Leu Val Ser Ala Leu Ala Cys Gly Ala Asp Trp Val Phe Leu Pro 
 225                230                235                240
Glu Ser Pro Pro Glu Glu Gly Trp Glu Glu Gln Met Cys Val Lys Leu 
                 245                250                255
Ser Glu Asn Arg Ala Arg Lys Lys Arg Leu Asn Ile Ile Ile Val Ala 
             260                265                270
Glu Gly Ala Ile Asp Thr Gln Asn Lys Pro Ile Thr Ser Glu Lys Ile 
         275                280                285
Lys Glu Leu Val Val Thr Gln Leu Gly Tyr Asp Thr Arg Val Thr Ile 
     290                295                300
Leu Gly His Val Gln Arg Gly Gly Thr Pro Ser Ala Phe Asp Arg Ile 
 305                310                315                320
Leu Ala Ser Arg Met Gly Val Glu Ala Val Ile Ala Leu Leu Glu Ala 
                 325                330                335
Thr Pro Asp Thr Pro Ala Cys Val Val Ser Leu Asn Gly Asn His Ala 
             340                345                350
Val Arg Leu Pro Leu Met Glu Cys Val Gln Met Thr Gln Asp Val Gln 
         355                360                365
Lys Ala Met Asp Glu Arg Arg Phe Gln Asp Ala Val Arg Leu Arg Gly 
     370                375                380
Arg Ser Phe Ala Gly Asn Leu Asn Thr Tyr Lys Arg Leu Ala Ile Lys 
 385                390                395                400
Leu Pro Asp Asp Gln Ile Pro Lys Thr Asn Cys Asn Val Ala Val Ile 
                 405                410                415
Asn Val Gly Ala Pro Ala Ala Gly Met Asn Ala Ala Val Arg Ser Ala 
             420                425                430
Val Arg Val Gly Ile Ala Asp Gly His Arg Met Leu Ala Ile Tyr Asp 
         435                440                445
Gly Phe Asp Gly Phe Ala Lys Gly Gln Ile Lys Glu Ile Gly Trp Thr 
     450                455                460
Asp Val Gly Gly Trp Thr Gly Gln Gly Gly Ser Ile Leu Gly Thr Lys 
 465                470                475                480
Arg Val Leu Pro Gly Lys Tyr Leu Glu Glu Ile Ala Thr Gln Met Arg 
                 485                490                495
Thr His Ser Ile Asn Ala Leu Leu Ile Ile Gly Gly Phe Glu Ala Tyr 
             500                505                510
Leu Gly Leu Leu Glu Leu Ser Ala Ala Arg Glu Lys His Glu Glu Phe 
         515                520                525
Cys Val Pro Met Val Met Val Pro Ala Thr Val Ser Asn Asn Val Pro 
     530                535                540
Gly Ser Asp Phe Ser Ile Gly Ala Asp Thr Ala Leu Asn Thr Ile Thr 
 545                550                555                560
Asp Thr Cys Asp Arg Ile Lys Gln Ser Ala Ser Gly Thr Lys Arg Arg 
                 565                570                575
Val Phe Ile Ile Glu Thr Met Gly Gly Tyr Cys Gly Tyr Leu Ala Asn 
             580                585                590
Met Gly Gly Leu Ala Ala Gly Ala Asp Ala Ala Tyr Ile Phe Glu Glu 
         595                600                605
Pro Phe Asp Ile Arg Asp Leu Gln Ser Asn Val Glu His Leu Thr Glu 
     610                615                620
Lys Met Lys Thr Thr Ile Gln Arg Gly Leu Val Leu Arg Asn Glu Ser 
 625                630                635                640
Cys Ser Glu Asn Tyr Thr Thr Asp Phe Ile Tyr Gln Leu Tyr Ser Glu 
                 645                650                655
Glu Gly Lys Gly Val Phe Asp Cys Arg Lys Asn Val Leu Gly His Met 
             660                665                670
Gln Gln Gly Gly Ala Pro Ser Pro Phe Asp Arg Asn Phe Gly Thr Lys 
         675                680                685
Ile Ser Ala Arg Ala Met Glu Trp Ile Thr Ala Lys Leu Lys Glu Ala 
     690                695                700
Arg Gly Arg Gly Lys Lys Phe Thr Thr Asp Asp Ser Ile Cys Val Leu 
 705                710                715                720
Gly Ile Ser Lys Arg Asn Val Ile Phe Gln Pro Val Ala Glu Leu Lys 
                 725                730                735
Lys Gln Thr Asp Phe Glu His Arg Ile Pro Lys Glu Gln Trp Trp Leu 
             740                745                750
Lys Leu Arg Pro Leu Met Lys Ile Leu Ala Lys Tyr Lys Ala Ser Tyr 
         755                760                765
Asp Val Ser Asp Ser Gly Gln Leu Glu His Val Gln Pro Trp Ser Val 
     770                775                780



<210> 9692
<211> 1796
<212> DNA
<213> Rattus norvegicus
<308> X59132
<400> 9692

tttgttaac  gtcttgcca  ctccttcag  gagcagcag  ctcaagcct  gctgtggat  60
tgatcggac  gggtaggtc  agccatggt  tctctgggc  tggaggtcg  ccagggtcc  120
ggaccacgt  caggtcgct  agctggacg  agaaccggc  accaagctc  tgaaggggc  180
agaacgcaa  ggggagcaa  agtgggcgg  gcatgctca  caccatgag  ccccggctg  240
ccctgcttc  gctgaggct  ttgctgctc  ccaaagcag  gcacaccgt  ggagttccg  300
cccgactgt  tgacgtgcg  cgtgtgctg  ttgaggaac  ggcccactg  ctacagcaa  360
tctccaaag  gaagaaagg  gcactgggc  cggagacag  atcaggctg  gaggggctt  420
gggacaaca  gagctgctg  ccctcctct  caccagcac  gacagtgga  gtgcagtgt  480
cgaagttcc  cctgatgct  tcaaacaaa  atgggtctc  gttccggaa  tgcacacaa  540
atggatggt  agaaacctt  cccaggcct  acctggcct  tggggtcaa  ataaacaac  600
cctttaatg  gagacggca  gcgtacctg  tgaaactca  ggtcatgta  actgtaggc  660
acagttcct  cttggccat  ctcctggtc  ccctcagca  cctgtgctc  ttccggagg  720
tgcactgca  tcgcaacta  atccacatg  acctgttcg  gtccttcat  ctgcgcgcc  780
tgtccaact  catcaagga  gccgtactc  tctcctcgg  cgacgtcac  tactgtgat  840
cccataagg  gggctgcaa  ctggtcatg  tcttcttcc  gtactgcat  atggccaac  900
acgcatggc  gctggtgga  ggcctctac  ttcacacac  ccttgccat  tccttcttc  960
cagaaagga  gtacctgca  gcctttgtg  tcctcggat  gggttctcc  gccattttt  1020
ttgctttgt  ggctatcac  aggcacttt  tagaaaata  tggatgctg  gacatcaac  1080
ccaatgctt  cgtctggtg  gtcattcga  ggcctgtga  tctgtccat  ctgatcaat  1140
tcatcttct  cataaacat  ctaagaatc  tgatgagga  acttagaac  caagaaaca  1200
gaggaagtg  aacaaacca  tataagcgc  tggccaagt  caccctcct  ctgatcccg  1260
tctttggca  ccactacat  gtcttcgcc  tctccccag  ggacgccat  gaggtccag  1320
tgttcttcg  actggccct  ggctccttc  agggtctgg  ggtagctgt  ctttactgc  1380
tcctcaatg  tgaggtgca  ttggaagtt  agaaaaaat  gcgccagtg  caccttcaa  1440
agttcccgc  gcgccctgt  gccttcaat  actccttca  caacgccac  aacggcccc  1500
cccacagca  caaggctag  actgagcaa  gccggagca  ccccagggc  agtatcatc  1560
gaggctgca  caaggcgcc  gcggacgaa  ggttggata  tcggtagga  ggacatctg  1620
ctgatagcc  tctcgtgct  gactggctg  acaggcttg  ctctcgggt  cgagcttcc  1680
cggagatca  gcaagagga  actactagg  catcgcgga  caggaaacg  acccatgac  1740
tggtttttc  tgttcttct  agaagagca  ttcagcaac  ccagaaggg  cagggg  1796



<210> 9693
<211> 449
<212> PRT
<213> Rattus norvegicus
<308> P23811
<400> 9693

Met Leu Ser Thr Met Arg Pro Arg Leu Ser Leu Leu Leu Leu Arg Leu 
  1               5                  10                  15
Leu Leu Leu Thr Lys Ala Ala His Thr Val Gly Val Pro Pro Arg Leu 
             20                  25                  30
Cys Asp Val Arg Arg Val Leu Leu Glu Glu Arg Ala His Cys Leu Gln 
         35                  40                  45
Gln Leu Ser Lys Glu Lys Lys Gly Ala Leu Gly Pro Glu Thr Ala Ser 
     50                  55                  60
Gly Cys Glu Gly Leu Trp Asp Asn Met Ser Cys Trp Pro Ser Ser Ala 
 65                  70                  75                  80
Pro Ala Arg Thr Val Glu Val Gln Cys Pro Lys Phe Leu Leu Met Leu 
                 85                  90                  95
Ser Asn Lys Asn Gly Ser Leu Phe Arg Asn Cys Thr Gln Asp Gly Trp 
             100                105                110
Ser Glu Thr Phe Pro Arg Pro Asp Leu Ala Cys Gly Val Asn Ile Asn 
         115                120                125
Asn Ser Phe Asn Glu Arg Arg His Ala Tyr Leu Leu Lys Leu Lys Val 
     130                135                140
Met Tyr Thr Val Gly Tyr Ser Ser Ser Leu Ala Met Leu Leu Val Ala 
 145                150                155                160
Leu Ser Ile Leu Cys Ser Phe Arg Arg Leu His Cys Thr Arg Asn Tyr 
                 165                170                175
Ile His Met His Leu Phe Val Ser Phe Ile Leu Arg Ala Leu Ser Asn 
             180                185                190
Phe Ile Lys Asp Ala Val Leu Phe Ser Ser Asp Asp Val Thr Tyr Cys 
         195                200                205
Asp Ala His Lys Val Gly Cys Lys Leu Val Met Ile Phe Phe Gln Tyr 
     210                215                220
Cys Ile Met Ala Asn Tyr Ala Trp Leu Leu Val Glu Gly Leu Tyr Leu 
 225                230                235                240
His Thr Leu Leu Ala Ile Ser Phe Phe Ser Glu Arg Lys Tyr Leu Gln 
                 245                250                255
Ala Phe Val Leu Leu Gly Trp Gly Ser Pro Ala Ile Phe Val Ala Leu 
             260                265                270
Trp Ala Ile Thr Arg His Phe Leu Glu Asn Thr Gly Cys Trp Asp Ile 
         275                280                285
Asn Ala Asn Ala Ser Val Trp Trp Val Ile Arg Gly Pro Val Ile Leu 
     290                295                300
Ser Ile Leu Ile Asn Phe Ile Phe Phe Ile Asn Ile Leu Arg Ile Leu 
 305                310                315                320
Met Arg Lys Leu Arg Thr Gln Glu Thr Arg Gly Ser Glu Thr Asn His 
                 325                330                335
Tyr Lys Arg Leu Ala Lys Ser Thr Leu Leu Leu Ile Pro Leu Phe Gly 
             340                345                350
Ile His Tyr Ile Val Phe Ala Phe Ser Pro Glu Asp Ala Met Glu Val 
         355                360                365
Gln Leu Phe Phe Glu Leu Ala Leu Gly Ser Phe Gln Gly Leu Val Val 
     370                375                380
Ala Val Leu Tyr Cys Phe Leu Asn Gly Glu Val Gln Leu Glu Val Gln 
 385                390                395                400
Lys Lys Trp Arg Gln Trp His Leu Gln Glu Phe Pro Leu Arg Pro Val 
                 405                410                415
Ala Phe Asn Asn Ser Phe Ser Asn Ala Thr Asn Gly Pro Thr His Ser 
             420                425                430
Thr Lys Ala Ser Thr Glu Gln Ser Arg Ser Ile Pro Arg Ala Ser Ile 
         435                440                445
Ile 
     450



<210> 9694
<211> 371
<212> DNA
<213> Homo sapiens
<308> AI220044
<400> 9694

tttctcact  cagcatgta  caaattaga  tggccacct  gagacccag  tcctcattc  60
ggttatgct  acagaatgt  ttacccgga  agagctgaa  tctagggcc  cagtttccc  120
agtgcactg  tggcaggtg  gcctggctg  gtcccagcc  ctcaggctc  ggcctctat  180
tccctacat  ctctccctg  aggaggctc  actgcactc  caactacat  cacatgcac  240
tgttcgtgt  cttcatcct  cgtgccctg  ccaacttca  caaggacgc  gtgctcttc  300
cctcagatg  tgtcaccta  tgcgatgcc  acagggtaa  atgtctggg  gccccagga  360
gtcgccagg  c  371



<210> 9695
<211> 440
<212> PRT
<213> Homo sapiens
<308> P47872
<400> 9695

Met Arg Pro His Leu Ser Pro Pro Leu Gln Gln Leu Leu Leu Pro Val 
  1               5                  10                  15
Leu Leu Ala Cys Ala Ala His Ser Thr Gly Ala Leu Pro Arg Leu Cys 
             20                  25                  30
Asp Val Leu Gln Val Leu Trp Glu Glu Gln Asp Gln Cys Leu Gln Glu 
         35                  40                  45
Leu Ser Arg Glu Gln Thr Gly Asp Leu Gly Thr Glu Gln Pro Val Pro 
     50                  55                  60
Gly Cys Glu Gly Met Trp Asp Asn Ile Ser Cys Trp Pro Ser Ser Val 
 65                  70                  75                  80
Pro Gly Arg Met Val Glu Val Glu Cys Pro Arg Phe Leu Arg Met Leu 
                 85                  90                  95
Thr Ser Arg Asn Gly Ser Leu Phe Arg Asn Cys Thr Gln Asp Gly Trp 
             100                105                110
Ser Glu Thr Phe Pro Arg Pro Asn Leu Ala Cys Gly Val Asn Val Asn 
         115                120                125
Asp Ser Ser Asn Glu Lys Arg His Ser Tyr Leu Leu Lys Leu Lys Val 
     130                135                140
Met Tyr Thr Val Gly Tyr Ser Ser Ser Leu Val Met Leu Leu Val Ala 
 145                150                155                160
Leu Gly Ile Leu Cys Ala Phe Arg Arg Leu His Cys Thr Arg Asn Tyr 
                 165                170                175
Ile His Met His Leu Phe Val Ser Phe Ile Leu Arg Ala Leu Ser Asn 
             180                185                190
Phe Ile Lys Asp Ala Val Leu Phe Ser Ser Asp Asp Val Thr Tyr Cys 
         195                200                205
Asp Ala His Arg Ala Gly Cys Lys Leu Val Met Val Leu Phe Gln Tyr 
     210                215                220
Cys Ile Met Ala Asn Tyr Ser Trp Leu Leu Val Glu Gly Leu Tyr Leu 
 225                230                235                240
His Thr Leu Leu Ala Ile Ser Phe Phe Ser Glu Arg Lys Tyr Leu Gln 
                 245                250                255
Gly Phe Val Ala Phe Gly Trp Gly Ser Pro Ala Ile Phe Val Ala Leu 
             260                265                270
Trp Ala Ile Ala Arg His Phe Leu Glu Asp Val Gly Cys Trp Asp Ile 
         275                280                285
Asn Ala Asn Ala Ser Ile Trp Trp Ile Ile Arg Gly Pro Val Ile Leu 
     290                295                300
Ser Ile Leu Ile Asn Phe Ile Leu Phe Ile Asn Ile Leu Arg Ile Leu 
 305                310                315                320
Met Arg Lys Leu Arg Thr Gln Glu Thr Arg Gly Asn Glu Val Ser His 
                 325                330                335
Tyr Lys Arg Leu Ala Arg Ser Thr Leu Leu Leu Ile Pro Leu Phe Gly 
             340                345                350
Ile His Tyr Ile Val Phe Ala Phe Ser Pro Glu Asp Ala Met Glu Ile 
         355                360                365
Gln Leu Phe Phe Glu Leu Ala Leu Gly Ser Phe Gln Gly Leu Val Val 
     370                375                380
Ala Val Leu Tyr Cys Phe Leu Asn Gly Glu Val Gln Leu Glu Val Gln 
 385                390                395                400
Lys Lys Trp Gln Gln Trp His Leu Arg Glu Phe Pro Leu His Pro Val 
                 405                410                415
Ala Ser Phe Ser Asn Ser Thr Lys Ala Ser His Leu Glu Gln Ser Gln 
             420                425                430
Gly Thr Cys Arg Thr Ser Ile Ile 
         435                440



<210> 9696
<211> 471
<212> DNA
<213> Rattus norvegicus
<308> X59677
<400> 9696

gctagtgac  cgaccactc  tgagatcac  accactcct  atgtgaaca  cactgctga  60
gtcaccacc  ctcctgatg  gaccaccat  gctgatgtc  ccaccactg  tagtatcac  120
accactcct  atgtgacca  cacccctga  gtgaccacc  ctgctgatg  caccaccac  180
gctggtatc  ccaccactc  tgatctgac  accactacg  tatttctac  catcctggc  240
tccatggca  aagccatct  tcttcaccc  ctctacgtc  tgctcccct  caccctggc  300
gcctccctg  ctttcatgc  acctgtggc  actccaccc  acgccattg  attctcctt  360
ggaggcctc  aggtgtctg  tatggcccg  gctggattc  tgctcaata  catcggagt  420
ctggctatc  cattatcca  caacagctg  agtatcccc  tcttcaagc  g  471



<210> 9697
<211> 157
<212> PRT
<213> Rattus norvegicus
<308> CAA42203
<400> 9697

Ala Ser Asp Thr Thr Thr Leu Glu Ile Thr Thr Thr Pro Asp Val Asn 
  1               5                  10                  15
Thr Thr Ala Asp Val Thr Thr Thr Pro Asp Val Thr Thr Ile Ala Asp 
             20                  25                  30
Val Thr Thr Thr Ala Ser Ile Thr Thr Thr Pro Asp Val Thr Thr Thr 
         35                  40                  45
Pro Asp Val Thr Thr Thr Ala Asp Val Thr Thr Thr Ala Gly Ile Thr 
     50                  55                  60
Thr Thr Pro Asp Leu Thr Thr Thr Thr Leu Phe Leu Pro Ile Leu Ala 
 65                  70                  75                  80
Ser Met Ala Gln Ala Ile Cys Leu His Pro Leu Tyr Val Met Leu Pro 
                 85                  90                  95
Cys Thr Leu Ala Ala Ser Leu Ala Phe Met Leu Pro Val Ala Thr Pro 
             100                105                110
Pro Asn Ala Ile Val Phe Ser Phe Gly Gly Leu Lys Val Ser Asp Met 
         115                120                125
Ala Arg Ala Gly Phe Leu Leu Asn Ile Ile Gly Val Leu Ala Ile Thr 
     130                135                140
Leu Ser Ile Asn Ser Trp Ser Ile Pro Ile Phe Lys Leu 
 145                150                155



<210> 9698
<211> 1953
<212> DNA
<213> Homo sapiens
<308> NM_003984
<400> 9698

gatctttgg  ccttctgtt  cccagctcc  ggaggcagt  gctgtagca  cccttgctg  60
tccacacca  ggccacctg  tggcaggcc  tgtgggcct  tcgctccta  ctgatcgtg  120
tcttcgtgc  cattctcct  ctgcctctg  ccatcctcg  ccccagtaa  gaggcctac  180
gcgcgtatg  catcatcct  atggcgctc  tctggtgca  tgaggccct  cccctggcc  240
tcactgccc  cttcccctt  atcctgttc  ctatgatgg  catcgtgga  gcctctgag  300
ttgccgtcg  gtatcttaa  gactccaac  tcctgttct  cggggggct  ctggtggcc  360
tcgcggtgg  acactggaa  ctgcataaa  gcatcgccc  ccgtgtcct  ctcatcgtt  420
gggtgcggc  tgccccgct  atcctgggc  tcatgctgg  cacggcctt  ctgtccatg  480
ggatcagca  cacggccac  tcagccatg  tggtgccca  cgcacatgc  gtcctggac  540
agctgcaca  ctcgcaagc  agcagcaac  tcgaggagg  cagcaacaa  cccaccttc  600
agctccagg  accaagtcc  cagaaggag  tgaccaagc  tgataatgg  caggccctc  660
ctgtcacgt  tgcctcttc  gaggggagg  cacatctca  ccagaagca  ctccacctc  720
cccagtgca  gagcctgtg  gtgtgctac  ccgccagca  cgggggcat  gccacgctg  780
ctggcaccg  acccaacct  gtgctgcaa  gccagatca  ctcgctctt  ccccaaaac  840
gcaacgtgg  gaacttcgc  tcctggttc  gcttcgcct  ccccaccat  gtcatcttg  900
tgctgctgg  ctggttgtg  ctgcagatc  tcttcctgg  cttcaactt  cggaagaac  960
ttggcattg  ggaaaagat  caggagcaa  agcaggcag  ctactgcgt  atccagacc  1020
agcacaggc  gctgggccc  atgaccttt  cagaaaagg  catcagcat  ctattcgtc  1080
tcctggtgc  gctctggtt  acccgggag  cgggctttt  tcttggctg  ggcaatttg  1140
cttttccca  tgccaaggg  gagagcatg  tgtccgatg  gacagtggc  atcttcatc  1200
gcataatta  gttcatcat  ccctccaag  tcccagggc  gacccagga  ccagaaaac  1260
cagggaagc  gaaggcccc  cttggcctc  tcgactgga  gacggtgaa  cagaagatg  1320
cgtggaata  cgtgttatt  ctgggtggt  gctatgccc  ggccaaggg  agtgagcga  1380
cgggcctgt  agagtggct  ggaaacaag  tgaccccac  gcagagtgt  ccagctcca  1440
ccattgcca  catcctctc  ctcctggtg  ccaccttca  cgagtgcac  agcaacgtg  1500
ccaccacta  gatcttcct  cccatccta  cctccatgg  ccaggccat  tgcctccac  1560
ctctctacg  catgctccc  tgcactctg  ccacctccc  ggccttcat  ttgcctgtg  1620
ccaccccgc  caatgccat  gtcttctct  tcggggacc  caaagtgtt  gatatggcc  1680
gggcaggat  cctcctcaa  atcattgga  tcctgatca  cgcactggc  atcaacagc  1740
ggggcatcc  cctcttcag  ctgcactct  tcccctcct  ggcacagtc  aacaccaca  1800
cccagtgcc  gccaagcct  gccaacacc  ccacaccaa  cccctaggc  ggggcacag  1860
ctggccatg  ccaggaaga  ccaccccat  cccactcct  tgagcccgg  ggggacacc  1920
caagctcca  gctccaagc  ccaggccgg  att  1953



<210> 9699
<211> 592
<212> PRT
<213> Homo sapiens
<308> Q13183
<400> 9699

Met Ala Thr Cys Trp Gln Ala Leu Trp Ala Tyr Arg Ser Tyr Leu Ile 
  1               5                  10                  15
Val Phe Phe Val Pro Ile Leu Leu Leu Pro Leu Pro Ile Leu Val Pro 
             20                  25                  30
Ser Lys Glu Ala Tyr Cys Ala Tyr Ala Ile Ile Leu Met Ala Leu Phe 
         35                  40                  45
Trp Cys Thr Glu Ala Leu Pro Leu Ala Val Thr Ala Leu Phe Pro Leu 
     50                  55                  60
Ile Leu Phe Pro Met Met Gly Ile Val Asp Ala Ser Glu Val Ala Val 
 65                  70                  75                  80
Glu Tyr Leu Lys Asp Ser Asn Leu Leu Phe Phe Gly Gly Leu Leu Val 
                 85                  90                  95
Ala Ile Ala Val Glu His Trp Asn Leu His Lys Arg Ile Ala Leu Arg 
             100                105                110
Val Leu Leu Ile Val Gly Val Arg Pro Ala Pro Leu Ile Leu Gly Phe 
         115                120                125
Met Leu Val Thr Ala Phe Leu Ser Met Trp Ile Ser Asn Thr Ala Thr 
     130                135                140
Ser Ala Met Met Val Pro Ile Ala His Ala Val Leu Asp Gln Leu His 
 145                150                155                160
Ser Ser Gln Ala Ser Ser Asn Val Glu Glu Gly Ser Asn Asn Pro Thr 
                 165                170                175
Phe Glu Leu Gln Glu Pro Ser Pro Gln Lys Glu Val Thr Lys Leu Asp 
             180                185                190
Asn Gly Gln Ala Leu Pro Val Thr Ser Ala Ser Ser Glu Gly Arg Ala 
         195                200                205
His Leu Ser Gln Lys His Leu His Leu Thr Gln Cys Met Ser Leu Cys 
     210                215                220
Val Cys Tyr Ser Ala Ser Ile Gly Gly Ile Ala Thr Leu Thr Gly Thr 
 225                230                235                240
Ala Pro Asn Leu Val Leu Gln Gly Gln Ile Asn Ser Leu Phe Pro Gln 
                 245                250                255
Asn Gly Asn Val Val Asn Phe Ala Ser Trp Phe Ser Phe Ala Phe Pro 
             260                265                270
Thr Met Val Ile Leu Leu Leu Leu Ala Trp Leu Trp Leu Gln Ile Leu 
         275                280                285
Phe Leu Gly Phe Asn Phe Arg Lys Asn Phe Gly Ile Gly Glu Lys Met 
     290                295                300
Gln Glu Gln Gln Gln Ala Ala Tyr Cys Val Ile Gln Thr Glu His Arg 
 305                310                315                320
Leu Leu Gly Pro Met Thr Phe Ala Glu Lys Ala Ile Ser Ile Leu Phe 
                 325                330                335
Val Ile Leu Val Leu Leu Trp Phe Thr Arg Glu Pro Gly Phe Phe Leu 
             340                345                350
Gly Trp Gly Asn Leu Ala Phe Pro Asn Ala Lys Gly Glu Ser Met Val 
         355                360                365
Ser Asp Gly Thr Val Ala Ile Phe Ile Gly Ile Ile Met Phe Ile Ile 
     370                375                380
Pro Ser Lys Phe Pro Gly Leu Thr Gln Asp Pro Glu Asn Pro Gly Lys 
 385                390                395                400
Leu Lys Ala Pro Leu Gly Leu Leu Asp Trp Lys Thr Val Asn Gln Lys 
                 405                410                415
Met Pro Trp Asn Ile Val Leu Leu Leu Gly Gly Gly Tyr Ala Leu Ala 
             420                425                430
Lys Gly Ser Glu Arg Ser Gly Leu Ser Glu Trp Leu Gly Asn Lys Leu 
         435                440                445
Thr Pro Leu Gln Ser Val Pro Ala Pro Ala Ile Ala Ile Ile Leu Ser 
     450                455                460
Leu Leu Val Ala Thr Phe Thr Glu Cys Thr Ser Asn Val Ala Thr Thr 
 465                470                475                480
Thr Ile Phe Leu Pro Ile Leu Ala Ser Met Ala Gln Ala Ile Cys Leu 
                 485                490                495
His Pro Leu Tyr Val Met Leu Pro Cys Thr Leu Ala Thr Ser Leu Ala 
             500                505                510
Phe Met Leu Pro Val Ala Thr Pro Pro Asn Ala Ile Val Phe Ser Phe 
         515                520                525
Gly Asp Leu Lys Val Leu Asp Met Ala Arg Ala Gly Phe Leu Leu Asn 
     530                535                540
Ile Ile Gly Val Leu Ile Ile Ala Leu Ala Ile Asn Ser Trp Gly Ile 
 545                550                555                560
Pro Leu Phe Ser Leu His Ser Phe Pro Ser Trp Ala Gln Ser Asn Thr 
                 565                570                575
Thr Ala Gln Cys Leu Pro Ser Leu Ala Asn Thr Thr Thr Pro Ser Pro 
             580                585                590



<210> 9700
<211> 1543
<212> DNA
<213> Rattus norvegicus
<308> X59737
<400> 9700

cgtagaaac  caccattcc  tgcccaacc  cagccccac  cccagagca  tcaacagtt  60
cagatttgc  ccagatcct  ctccaaatc  ggtagccgc  tcccaagcc  tggctggtc  120
cttctcccg  ctgctgtct  cccgccccg  actcaagct  ctggctttg  ctggagctg  180
gtctctcgc  gccgggatt  tgctccgtc  ggaatctgt  cgagcggcc  ccggtgaac  240
gaggagact  tatcccccg  gcgctgagt  cccagacct  cgaaagcac  acaactgca  300
ggccagtca  ctgacccca  cagtctatg  acggctctg  gacaagacc  cacccactg  360
ctggacact  gatcagtgc  tccagactg  agtggacaa  cctggccac  ccttcatca  420
gactgtggg  atggtggct  gagatgagg  gacctatga  gtatttgcc  aactgtttg  480
ccctgtgat  caagagcgg  ataatggat  tgaccctag  acaatgaag  acaccactg  540
ccttgatgc  agcaaaatc  gttctggct  ctttgatga  aggtacgta  tgtcctcaa  600
agtcagaac  ggccgaagt  tcaggggac  cagtctccc  ccagcctgc  ctcgggcag  660
gcgacgaga  gtggagcgt  ttgtggtgg  cgcgctgag  ggcctgaag  gcgacctgg  720
tggacggta  tacaggctc  gtgagatga  agaggctga  cagcagcag  ttattgacg  780
ccatttcct  tttgataaa  ctgtgtccc  attgctgac  gcagcaggc  tggctcgag  840
ctggccaga  gcccgagga  tctggcaca  caatgagaa  agtttcttg  tctgggtga  900
tgaggagga  cacacacgg  tcatctcta  ggagaaagg  ggcaacatg  agagagtgt  960
tgaaagatt  tgccggggc  tcaaaaagg  ggagaagct  atccaggaa  gaggctggg  1020
gttcatgtg  aatgagcgt  taggataca  cttgacctg  ccatctaac  tgggcactg  1080
acttcgggc  ggagtacac  tcaaactgc  actgctaag  aaagatagc  gcttcccaa  1140
gatcctgga  aacctaagg  tgcaaaagc  tgggactgg  ggagtggac  cgcctgcca  1200
agcggatgt  tttgacatc  ctaatctgg  tcgacttgg  aagtcagag  tggagctgg  1260
gcagctggt  atcgatggg  tgaactatt  gattgactg  gaacggcgt  tggagaaag  1320
acaggatat  cgaatccct  cacctcttg  ccacggcaa  cattaactc  ccgtcccca  1380
cagctgaat  aagattccc  aggacttct  catatttaa  agtggccca  tctacttgc  1440
aaggacctg  ctctcaatc  ctgtcctag  aaagactcc  cgttctgtt  caaaaaaaa  1500
aaaaaataa  gttcctatt  ctctgcaaa  aaaaaaaaa  aaa  1543



<210> 9701
<211> 418
<212> PRT
<213> Rattus norvegicus
<308> CAA42415
<400> 9701

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Lys 
  1               5                  10                  15
Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Ile Leu Leu 
             20                  25                  30
Arg Pro Glu Ser Val Arg Ala Ala Thr Gly Glu Arg Arg Arg Leu Tyr 
         35                  40                  45
Pro Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met 
     50                  55                  60
Ala Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr 
 65                  70                  75                  80
Thr Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp 
                 85                  90                  95
Asn Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp 
             100                105                110
Glu Glu Thr Tyr Glu Val Phe Ala Glu Leu Phe Asp Pro Val Ile Gln 
         115                120                125
Glu Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp 
     130                135                140
Leu Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val 
 145                150                155                160
Leu Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu 
                 165                170                175
Pro Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val 
             180                185                190
Val Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr 
         195                200                205
Arg Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp 
     210                215                220
His Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly 
 225                230                235                240
Met Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu 
                 245                250                255
Lys Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile 
             260                265                270
Ser Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys 
         275                280                285
Arg Gly Leu Lys Lys Val Glu Lys Leu Ile Gln Glu Arg Gly Trp Glu 
     290                295                300
Phe Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn 
 305                310                315                320
Leu Gly Thr Gly Leu Arg Ala Gly Val His Val Lys Leu Pro Leu Leu 
                 325                330                335
Ser Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln 
             340                345                350
Lys Arg Gly Thr Gly Gly Val Asp Thr Pro Ala Thr Ala Asp Val Phe 
         355                360                365
Asp Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val 
     370                375                380
Gln Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg 
 385                390                395                400
Leu Glu Lys Gly Gln Asp Ile Arg Ile Pro Pro Pro Leu Val His Gly 
                 405                410                415
Lys His 
             420



<210> 9702
<211> 1528
<212> DNA
<213> Homo sapiens
<308> NM_020990
<400> 9702

ccggctccc  ttccggctc  agcctccaa  ccgaccccc  tttcggctg  agcctcgga  60
ctagctccg  ccctcggtc  atccggttg  atcctccct  cctgttccg  atcttatct  120
gcgccagcg  ctactccag  atcccgtag  cagacctca  gccatggct  gtcccttct  180
ccgtctgct  tccgcccgc  cgggactca  gctcctggc  ttggccgga  cggggtctc  240
agccgctgg  tttctgctc  gaccggaac  tgtacgagc  gccagtgaa  gacggaggc  300
gtatccccc  agcgctgag  acccagacc  ccgaaagca  aacaactgc  tggccagtc  360
cctgacccc  gcagtctat  cacggctct  cgacaagac  acacccact  gttggacgc  420
agatcagtg  atccagact  gcgtggaca  ccctggcca  cccttcatc  agactgtgg  480
catggtggc  ggagatgag  agacctatg  ggtatttgc  gacctgttt  accctgtga  540
ccaagagcg  cacaatgga  atgaccccc  gacaatgaa  cacaccacg  atctagatg  600
cagtaaaat  cgttctggc  actttgatg  gaggtatgt  ttgtcctct  gagtcagaa  660
tggccgaag  atccgagga  tcagtctgc  tccagcttg  actcgagca  agcgacgag  720
ggtggaacg  gttgtggtg  atgcactga  tggcctgaa  ggtgacctg  ctggacgtt  780
ctataggct  agtgagatg  cagaggctg  acagcagca  cttattgat  accactttc  840
gtttgataa  cctgtgtcc  cgttgctga  tgcagcagg  atggctcga  actggccag  900
tgctcgtgg  atttggcac  acaatgaga  gagcttcct  atctgggtg  atgaggagg  960
tcatacacg  gtgatctcc  tggagaagg  tggtaacat  aagagagtg  ttgaaagat  1020
ctgccgagg  ctcaaagag  tggagagac  tatccaaga  cgtggctgg  agttcatgt  1080
gaatgagcg  ttgggatac  tcttgacct  tccatctaa  ctgggcact  gacttcggg  1140
aggagtgca  atcaaactg  ccctgctaa  caaagatag  cgcttccca  agatcctgg  1200
gaacctaag  ctccaaaaa  gtggtactg  aggagtgga  actgctgct  caggcggtg  1260
ctttgatat  tctaatttg  accgactag  caaatcaga  gtggagctg  tgcaactgg  1320
catcgatgg  gtaaactat  tgattgatt  tgaacggcg  ctggagaga  gccaggata  1380
ccgcatccc  acacctgtc  tccacacca  gcattaact  cccatcgcc  gctgatgac  1440
caagattcc  aggagtttt  ctcattcta  tgatggccc  ttctacttg  tctggacct  1500
cccccgcat  ccctgcctc  atcctagt  1528



<210> 9703
<211> 417
<212> PRT
<213> Homo sapiens
<308> NP_066270
<400> 9703

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
  1               5                  10                  15
Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
             20                  25                  30
Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
         35                  40                  45
Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
     50                  55                  60
Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
 65                  70                  75                  80
Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                 85                  90                  95
Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
             100                105                110
Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
         115                120                125
Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
     130                135                140
Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
 145                150                155                160
Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                 165                170                175
Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
             180                185                190
Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
         195                200                205
Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
     210                215                220
Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
 225                230                235                240
Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys 
                 245                250                255
Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser 
             260                265                270
Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg 
         275                280                285
Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu Phe 
     290                295                300
Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu 
 305                310                315                320
Gly Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Leu Leu Ser 
                 325                330                335
Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln Lys 
             340                345                350
Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Thr Gly Gly Val Phe Asp 
         355                360                365
Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val Gln 
     370                375                380
Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg Leu 
 385                390                395                400
Glu Arg Gly Gln Asp Ile Arg Ile Pro Thr Pro Val Ile His Thr Lys 
                 405                410                415
His 
             420



<210> 9704
<211> 1543
<212> DNA
<213> Rattus norvegicus
<308> X59737
<400> 9704

cgtagaaac  caccattcc  tgcccaacc  cagccccac  cccagagca  tcaacagtt  60
cagatttgc  ccagatcct  ctccaaatc  ggtagccgc  tcccaagcc  tggctggtc  120
cttctcccg  ctgctgtct  cccgccccg  actcaagct  ctggctttg  ctggagctg  180
gtctctcgc  gccgggatt  tgctccgtc  ggaatctgt  cgagcggcc  ccggtgaac  240
gaggagact  tatcccccg  gcgctgagt  cccagacct  cgaaagcac  acaactgca  300
ggccagtca  ctgacccca  cagtctatg  acggctctg  gacaagacc  cacccactg  360
ctggacact  gatcagtgc  tccagactg  agtggacaa  cctggccac  ccttcatca  420
gactgtggg  atggtggct  gagatgagg  gacctatga  gtatttgcc  aactgtttg  480
ccctgtgat  caagagcgg  ataatggat  tgaccctag  acaatgaag  acaccactg  540
ccttgatgc  agcaaaatc  gttctggct  ctttgatga  aggtacgta  tgtcctcaa  600
agtcagaac  ggccgaagt  tcaggggac  cagtctccc  ccagcctgc  ctcgggcag  660
gcgacgaga  gtggagcgt  ttgtggtgg  cgcgctgag  ggcctgaag  gcgacctgg  720
tggacggta  tacaggctc  gtgagatga  agaggctga  cagcagcag  ttattgacg  780
ccatttcct  tttgataaa  ctgtgtccc  attgctgac  gcagcaggc  tggctcgag  840
ctggccaga  gcccgagga  tctggcaca  caatgagaa  agtttcttg  tctgggtga  900
tgaggagga  cacacacgg  tcatctcta  ggagaaagg  ggcaacatg  agagagtgt  960
tgaaagatt  tgccggggc  tcaaaaagg  ggagaagct  atccaggaa  gaggctggg  1020
gttcatgtg  aatgagcgt  taggataca  cttgacctg  ccatctaac  tgggcactg  1080
acttcgggc  ggagtacac  tcaaactgc  actgctaag  aaagatagc  gcttcccaa  1140
gatcctgga  aacctaagg  tgcaaaagc  tgggactgg  ggagtggac  cgcctgcca  1200
agcggatgt  tttgacatc  ctaatctgg  tcgacttgg  aagtcagag  tggagctgg  1260
gcagctggt  atcgatggg  tgaactatt  gattgactg  gaacggcgt  tggagaaag  1320
acaggatat  cgaatccct  cacctcttg  ccacggcaa  cattaactc  ccgtcccca  1380
cagctgaat  aagattccc  aggacttct  catatttaa  agtggccca  tctacttgc  1440
aaggacctg  ctctcaatc  ctgtcctag  aaagactcc  cgttctgtt  caaaaaaaa  1500
aaaaaataa  gttcctatt  ctctgcaaa  aaaaaaaaa  aaa  1543



<210> 9705
<211> 418
<212> PRT
<213> Rattus norvegicus
<308> CAA42415
<400> 9705

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Lys 
  1               5                  10                  15
Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Ile Leu Leu 
             20                  25                  30
Arg Pro Glu Ser Val Arg Ala Ala Thr Gly Glu Arg Arg Arg Leu Tyr 
         35                  40                  45
Pro Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met 
     50                  55                  60
Ala Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr 
 65                  70                  75                  80
Thr Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp 
                 85                  90                  95
Asn Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp 
             100                105                110
Glu Glu Thr Tyr Glu Val Phe Ala Glu Leu Phe Asp Pro Val Ile Gln 
         115                120                125
Glu Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp 
     130                135                140
Leu Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val 
 145                150                155                160
Leu Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu 
                 165                170                175
Pro Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val 
             180                185                190
Val Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr 
         195                200                205
Arg Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp 
     210                215                220
His Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly 
 225                230                235                240
Met Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu 
                 245                250                255
Lys Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile 
             260                265                270
Ser Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys 
         275                280                285
Arg Gly Leu Lys Lys Val Glu Lys Leu Ile Gln Glu Arg Gly Trp Glu 
     290                295                300
Phe Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn 
 305                310                315                320
Leu Gly Thr Gly Leu Arg Ala Gly Val His Val Lys Leu Pro Leu Leu 
                 325                330                335
Ser Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln 
             340                345                350
Lys Arg Gly Thr Gly Gly Val Asp Thr Pro Ala Thr Ala Asp Val Phe 
         355                360                365
Asp Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val 
     370                375                380
Gln Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg 
 385                390                395                400
Leu Glu Lys Gly Gln Asp Ile Arg Ile Pro Pro Pro Leu Val His Gly 
                 405                410                415
Lys His 
             420



<210> 9706
<211> 1528
<212> DNA
<213> Homo sapiens
<308> NM_020990
<400> 9706

ccggctccc  ttccggctc  agcctccaa  ccgaccccc  tttcggctg  agcctcgga  60
ctagctccg  ccctcggtc  atccggttg  atcctccct  cctgttccg  atcttatct  120
gcgccagcg  ctactccag  atcccgtag  cagacctca  gccatggct  gtcccttct  180
ccgtctgct  tccgcccgc  cgggactca  gctcctggc  ttggccgga  cggggtctc  240
agccgctgg  tttctgctc  gaccggaac  tgtacgagc  gccagtgaa  gacggaggc  300
gtatccccc  agcgctgag  acccagacc  ccgaaagca  aacaactgc  tggccagtc  360
cctgacccc  gcagtctat  cacggctct  cgacaagac  acacccact  gttggacgc  420
agatcagtg  atccagact  gcgtggaca  ccctggcca  cccttcatc  agactgtgg  480
catggtggc  ggagatgag  agacctatg  ggtatttgc  gacctgttt  accctgtga  540
ccaagagcg  cacaatgga  atgaccccc  gacaatgaa  cacaccacg  atctagatg  600
cagtaaaat  cgttctggc  actttgatg  gaggtatgt  ttgtcctct  gagtcagaa  660
tggccgaag  atccgagga  tcagtctgc  tccagcttg  actcgagca  agcgacgag  720
ggtggaacg  gttgtggtg  atgcactga  tggcctgaa  ggtgacctg  ctggacgtt  780
ctataggct  agtgagatg  cagaggctg  acagcagca  cttattgat  accactttc  840
gtttgataa  cctgtgtcc  cgttgctga  tgcagcagg  atggctcga  actggccag  900
tgctcgtgg  atttggcac  acaatgaga  gagcttcct  atctgggtg  atgaggagg  960
tcatacacg  gtgatctcc  tggagaagg  tggtaacat  aagagagtg  ttgaaagat  1020
ctgccgagg  ctcaaagag  tggagagac  tatccaaga  cgtggctgg  agttcatgt  1080
gaatgagcg  ttgggatac  tcttgacct  tccatctaa  ctgggcact  gacttcggg  1140
aggagtgca  atcaaactg  ccctgctaa  caaagatag  cgcttccca  agatcctgg  1200
gaacctaag  ctccaaaaa  gtggtactg  aggagtgga  actgctgct  caggcggtg  1260
ctttgatat  tctaatttg  accgactag  caaatcaga  gtggagctg  tgcaactgg  1320
catcgatgg  gtaaactat  tgattgatt  tgaacggcg  ctggagaga  gccaggata  1380
ccgcatccc  acacctgtc  tccacacca  gcattaact  cccatcgcc  gctgatgac  1440
caagattcc  aggagtttt  ctcattcta  tgatggccc  ttctacttg  tctggacct  1500
cccccgcat  ccctgcctc  atcctagt  1528



<210> 9707
<211> 417
<212> PRT
<213> Homo sapiens
<308> NP_066270
<400> 9707

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
  1               5                  10                  15
Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
             20                  25                  30
Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
         35                  40                  45
Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
     50                  55                  60
Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
 65                  70                  75                  80
Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                 85                  90                  95
Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
             100                105                110
Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
         115                120                125
Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
     130                135                140
Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
 145                150                155                160
Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                 165                170                175
Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
             180                185                190
Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
         195                200                205
Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
     210                215                220
Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
 225                230                235                240
Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys 
                 245                250                255
Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser 
             260                265                270
Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg 
         275                280                285
Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu Phe 
     290                295                300
Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu 
 305                310                315                320
Gly Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Leu Leu Ser 
                 325                330                335
Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln Lys 
             340                345                350
Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Thr Gly Gly Val Phe Asp 
         355                360                365
Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val Gln 
     370                375                380
Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg Leu 
 385                390                395                400
Glu Arg Gly Gln Asp Ile Arg Ile Pro Thr Pro Val Ile His Thr Lys 
                 405                410                415
His 
             420



<210> 9708
<211> 1543
<212> DNA
<213> Rattus norvegicus
<308> X59737
<400> 9708

cgtagaaac  caccattcc  tgcccaacc  cagccccac  cccagagca  tcaacagtt  60
cagatttgc  ccagatcct  ctccaaatc  ggtagccgc  tcccaagcc  tggctggtc  120
cttctcccg  ctgctgtct  cccgccccg  actcaagct  ctggctttg  ctggagctg  180
gtctctcgc  gccgggatt  tgctccgtc  ggaatctgt  cgagcggcc  ccggtgaac  240
gaggagact  tatcccccg  gcgctgagt  cccagacct  cgaaagcac  acaactgca  300
ggccagtca  ctgacccca  cagtctatg  acggctctg  gacaagacc  cacccactg  360
ctggacact  gatcagtgc  tccagactg  agtggacaa  cctggccac  ccttcatca  420
gactgtggg  atggtggct  gagatgagg  gacctatga  gtatttgcc  aactgtttg  480
ccctgtgat  caagagcgg  ataatggat  tgaccctag  acaatgaag  acaccactg  540
ccttgatgc  agcaaaatc  gttctggct  ctttgatga  aggtacgta  tgtcctcaa  600
agtcagaac  ggccgaagt  tcaggggac  cagtctccc  ccagcctgc  ctcgggcag  660
gcgacgaga  gtggagcgt  ttgtggtgg  cgcgctgag  ggcctgaag  gcgacctgg  720
tggacggta  tacaggctc  gtgagatga  agaggctga  cagcagcag  ttattgacg  780
ccatttcct  tttgataaa  ctgtgtccc  attgctgac  gcagcaggc  tggctcgag  840
ctggccaga  gcccgagga  tctggcaca  caatgagaa  agtttcttg  tctgggtga  900
tgaggagga  cacacacgg  tcatctcta  ggagaaagg  ggcaacatg  agagagtgt  960
tgaaagatt  tgccggggc  tcaaaaagg  ggagaagct  atccaggaa  gaggctggg  1020
gttcatgtg  aatgagcgt  taggataca  cttgacctg  ccatctaac  tgggcactg  1080
acttcgggc  ggagtacac  tcaaactgc  actgctaag  aaagatagc  gcttcccaa  1140
gatcctgga  aacctaagg  tgcaaaagc  tgggactgg  ggagtggac  cgcctgcca  1200
agcggatgt  tttgacatc  ctaatctgg  tcgacttgg  aagtcagag  tggagctgg  1260
gcagctggt  atcgatggg  tgaactatt  gattgactg  gaacggcgt  tggagaaag  1320
acaggatat  cgaatccct  cacctcttg  ccacggcaa  cattaactc  ccgtcccca  1380
cagctgaat  aagattccc  aggacttct  catatttaa  agtggccca  tctacttgc  1440
aaggacctg  ctctcaatc  ctgtcctag  aaagactcc  cgttctgtt  caaaaaaaa  1500
aaaaaataa  gttcctatt  ctctgcaaa  aaaaaaaaa  aaa  1543



<210> 9709
<211> 418
<212> PRT
<213> Rattus norvegicus
<308> CAA42415
<400> 9709

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Lys 
  1               5                  10                  15
Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Ile Leu Leu 
             20                  25                  30
Arg Pro Glu Ser Val Arg Ala Ala Thr Gly Glu Arg Arg Arg Leu Tyr 
         35                  40                  45
Pro Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met 
     50                  55                  60
Ala Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr 
 65                  70                  75                  80
Thr Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp 
                 85                  90                  95
Asn Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp 
             100                105                110
Glu Glu Thr Tyr Glu Val Phe Ala Glu Leu Phe Asp Pro Val Ile Gln 
         115                120                125
Glu Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp 
     130                135                140
Leu Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val 
 145                150                155                160
Leu Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu 
                 165                170                175
Pro Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val 
             180                185                190
Val Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr 
         195                200                205
Arg Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp 
     210                215                220
His Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly 
 225                230                235                240
Met Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu 
                 245                250                255
Lys Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile 
             260                265                270
Ser Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys 
         275                280                285
Arg Gly Leu Lys Lys Val Glu Lys Leu Ile Gln Glu Arg Gly Trp Glu 
     290                295                300
Phe Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn 
 305                310                315                320
Leu Gly Thr Gly Leu Arg Ala Gly Val His Val Lys Leu Pro Leu Leu 
                 325                330                335
Ser Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln 
             340                345                350
Lys Arg Gly Thr Gly Gly Val Asp Thr Pro Ala Thr Ala Asp Val Phe 
         355                360                365
Asp Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val 
     370                375                380
Gln Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg 
 385                390                395                400
Leu Glu Lys Gly Gln Asp Ile Arg Ile Pro Pro Pro Leu Val His Gly 
                 405                410                415
Lys His 
             420



<210> 9710
<211> 1528
<212> DNA
<213> Homo sapiens
<308> NM_020990
<400> 9710

ccggctccc  ttccggctc  agcctccaa  ccgaccccc  tttcggctg  agcctcgga  60
ctagctccg  ccctcggtc  atccggttg  atcctccct  cctgttccg  atcttatct  120
gcgccagcg  ctactccag  atcccgtag  cagacctca  gccatggct  gtcccttct  180
ccgtctgct  tccgcccgc  cgggactca  gctcctggc  ttggccgga  cggggtctc  240
agccgctgg  tttctgctc  gaccggaac  tgtacgagc  gccagtgaa  gacggaggc  300
gtatccccc  agcgctgag  acccagacc  ccgaaagca  aacaactgc  tggccagtc  360
cctgacccc  gcagtctat  cacggctct  cgacaagac  acacccact  gttggacgc  420
agatcagtg  atccagact  gcgtggaca  ccctggcca  cccttcatc  agactgtgg  480
catggtggc  ggagatgag  agacctatg  ggtatttgc  gacctgttt  accctgtga  540
ccaagagcg  cacaatgga  atgaccccc  gacaatgaa  cacaccacg  atctagatg  600
cagtaaaat  cgttctggc  actttgatg  gaggtatgt  ttgtcctct  gagtcagaa  660
tggccgaag  atccgagga  tcagtctgc  tccagcttg  actcgagca  agcgacgag  720
ggtggaacg  gttgtggtg  atgcactga  tggcctgaa  ggtgacctg  ctggacgtt  780
ctataggct  agtgagatg  cagaggctg  acagcagca  cttattgat  accactttc  840
gtttgataa  cctgtgtcc  cgttgctga  tgcagcagg  atggctcga  actggccag  900
tgctcgtgg  atttggcac  acaatgaga  gagcttcct  atctgggtg  atgaggagg  960
tcatacacg  gtgatctcc  tggagaagg  tggtaacat  aagagagtg  ttgaaagat  1020
ctgccgagg  ctcaaagag  tggagagac  tatccaaga  cgtggctgg  agttcatgt  1080
gaatgagcg  ttgggatac  tcttgacct  tccatctaa  ctgggcact  gacttcggg  1140
aggagtgca  atcaaactg  ccctgctaa  caaagatag  cgcttccca  agatcctgg  1200
gaacctaag  ctccaaaaa  gtggtactg  aggagtgga  actgctgct  caggcggtg  1260
ctttgatat  tctaatttg  accgactag  caaatcaga  gtggagctg  tgcaactgg  1320
catcgatgg  gtaaactat  tgattgatt  tgaacggcg  ctggagaga  gccaggata  1380
ccgcatccc  acacctgtc  tccacacca  gcattaact  cccatcgcc  gctgatgac  1440
caagattcc  aggagtttt  ctcattcta  tgatggccc  ttctacttg  tctggacct  1500
cccccgcat  ccctgcctc  atcctagt  1528



<210> 9711
<211> 417
<212> PRT
<213> Homo sapiens
<308> NP_066270
<400> 9711

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
  1               5                  10                  15
Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
             20                  25                  30
Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
         35                  40                  45
Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
     50                  55                  60
Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
 65                  70                  75                  80
Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                 85                  90                  95
Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
             100                105                110
Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
         115                120                125
Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
     130                135                140
Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
 145                150                155                160
Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                 165                170                175
Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
             180                185                190
Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
         195                200                205
Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
     210                215                220
Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
 225                230                235                240
Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys 
                 245                250                255
Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser 
             260                265                270
Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg 
         275                280                285
Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu Phe 
     290                295                300
Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu 
 305                310                315                320
Gly Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Leu Leu Ser 
                 325                330                335
Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln Lys 
             340                345                350
Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Thr Gly Gly Val Phe Asp 
         355                360                365
Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val Gln 
     370                375                380
Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg Leu 
 385                390                395                400
Glu Arg Gly Gln Asp Ile Arg Ile Pro Thr Pro Val Ile His Thr Lys 
                 405                410                415
His 
             420



<210> 9712
<211> 1543
<212> DNA
<213> Rattus norvegicus
<308> X59737
<400> 9712

cgtagaaac  caccattcc  tgcccaacc  cagccccac  cccagagca  tcaacagtt  60
cagatttgc  ccagatcct  ctccaaatc  ggtagccgc  tcccaagcc  tggctggtc  120
cttctcccg  ctgctgtct  cccgccccg  actcaagct  ctggctttg  ctggagctg  180
gtctctcgc  gccgggatt  tgctccgtc  ggaatctgt  cgagcggcc  ccggtgaac  240
gaggagact  tatcccccg  gcgctgagt  cccagacct  cgaaagcac  acaactgca  300
ggccagtca  ctgacccca  cagtctatg  acggctctg  gacaagacc  cacccactg  360
ctggacact  gatcagtgc  tccagactg  agtggacaa  cctggccac  ccttcatca  420
gactgtggg  atggtggct  gagatgagg  gacctatga  gtatttgcc  aactgtttg  480
ccctgtgat  caagagcgg  ataatggat  tgaccctag  acaatgaag  acaccactg  540
ccttgatgc  agcaaaatc  gttctggct  ctttgatga  aggtacgta  tgtcctcaa  600
agtcagaac  ggccgaagt  tcaggggac  cagtctccc  ccagcctgc  ctcgggcag  660
gcgacgaga  gtggagcgt  ttgtggtgg  cgcgctgag  ggcctgaag  gcgacctgg  720
tggacggta  tacaggctc  gtgagatga  agaggctga  cagcagcag  ttattgacg  780
ccatttcct  tttgataaa  ctgtgtccc  attgctgac  gcagcaggc  tggctcgag  840
ctggccaga  gcccgagga  tctggcaca  caatgagaa  agtttcttg  tctgggtga  900
tgaggagga  cacacacgg  tcatctcta  ggagaaagg  ggcaacatg  agagagtgt  960
tgaaagatt  tgccggggc  tcaaaaagg  ggagaagct  atccaggaa  gaggctggg  1020
gttcatgtg  aatgagcgt  taggataca  cttgacctg  ccatctaac  tgggcactg  1080
acttcgggc  ggagtacac  tcaaactgc  actgctaag  aaagatagc  gcttcccaa  1140
gatcctgga  aacctaagg  tgcaaaagc  tgggactgg  ggagtggac  cgcctgcca  1200
agcggatgt  tttgacatc  ctaatctgg  tcgacttgg  aagtcagag  tggagctgg  1260
gcagctggt  atcgatggg  tgaactatt  gattgactg  gaacggcgt  tggagaaag  1320
acaggatat  cgaatccct  cacctcttg  ccacggcaa  cattaactc  ccgtcccca  1380
cagctgaat  aagattccc  aggacttct  catatttaa  agtggccca  tctacttgc  1440
aaggacctg  ctctcaatc  ctgtcctag  aaagactcc  cgttctgtt  caaaaaaaa  1500
aaaaaataa  gttcctatt  ctctgcaaa  aaaaaaaaa  aaa  1543



<210> 9713
<211> 418
<212> PRT
<213> Rattus norvegicus
<308> CAA42415
<400> 9713

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Lys 
  1               5                  10                  15
Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Ile Leu Leu 
             20                  25                  30
Arg Pro Glu Ser Val Arg Ala Ala Thr Gly Glu Arg Arg Arg Leu Tyr 
         35                  40                  45
Pro Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met 
     50                  55                  60
Ala Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr 
 65                  70                  75                  80
Thr Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp 
                 85                  90                  95
Asn Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp 
             100                105                110
Glu Glu Thr Tyr Glu Val Phe Ala Glu Leu Phe Asp Pro Val Ile Gln 
         115                120                125
Glu Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp 
     130                135                140
Leu Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val 
 145                150                155                160
Leu Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu 
                 165                170                175
Pro Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val 
             180                185                190
Val Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr 
         195                200                205
Arg Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp 
     210                215                220
His Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly 
 225                230                235                240
Met Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu 
                 245                250                255
Lys Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile 
             260                265                270
Ser Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys 
         275                280                285
Arg Gly Leu Lys Lys Val Glu Lys Leu Ile Gln Glu Arg Gly Trp Glu 
     290                295                300
Phe Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn 
 305                310                315                320
Leu Gly Thr Gly Leu Arg Ala Gly Val His Val Lys Leu Pro Leu Leu 
                 325                330                335
Ser Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln 
             340                345                350
Lys Arg Gly Thr Gly Gly Val Asp Thr Pro Ala Thr Ala Asp Val Phe 
         355                360                365
Asp Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val 
     370                375                380
Gln Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg 
 385                390                395                400
Leu Glu Lys Gly Gln Asp Ile Arg Ile Pro Pro Pro Leu Val His Gly 
                 405                410                415
Lys His 
             420



<210> 9714
<211> 1528
<212> DNA
<213> Homo sapiens
<308> NM_020990
<400> 9714

ccggctccc  ttccggctc  agcctccaa  ccgaccccc  tttcggctg  agcctcgga  60
ctagctccg  ccctcggtc  atccggttg  atcctccct  cctgttccg  atcttatct  120
gcgccagcg  ctactccag  atcccgtag  cagacctca  gccatggct  gtcccttct  180
ccgtctgct  tccgcccgc  cgggactca  gctcctggc  ttggccgga  cggggtctc  240
agccgctgg  tttctgctc  gaccggaac  tgtacgagc  gccagtgaa  gacggaggc  300
gtatccccc  agcgctgag  acccagacc  ccgaaagca  aacaactgc  tggccagtc  360
cctgacccc  gcagtctat  cacggctct  cgacaagac  acacccact  gttggacgc  420
agatcagtg  atccagact  gcgtggaca  ccctggcca  cccttcatc  agactgtgg  480
catggtggc  ggagatgag  agacctatg  ggtatttgc  gacctgttt  accctgtga  540
ccaagagcg  cacaatgga  atgaccccc  gacaatgaa  cacaccacg  atctagatg  600
cagtaaaat  cgttctggc  actttgatg  gaggtatgt  ttgtcctct  gagtcagaa  660
tggccgaag  atccgagga  tcagtctgc  tccagcttg  actcgagca  agcgacgag  720
ggtggaacg  gttgtggtg  atgcactga  tggcctgaa  ggtgacctg  ctggacgtt  780
ctataggct  agtgagatg  cagaggctg  acagcagca  cttattgat  accactttc  840
gtttgataa  cctgtgtcc  cgttgctga  tgcagcagg  atggctcga  actggccag  900
tgctcgtgg  atttggcac  acaatgaga  gagcttcct  atctgggtg  atgaggagg  960
tcatacacg  gtgatctcc  tggagaagg  tggtaacat  aagagagtg  ttgaaagat  1020
ctgccgagg  ctcaaagag  tggagagac  tatccaaga  cgtggctgg  agttcatgt  1080
gaatgagcg  ttgggatac  tcttgacct  tccatctaa  ctgggcact  gacttcggg  1140
aggagtgca  atcaaactg  ccctgctaa  caaagatag  cgcttccca  agatcctgg  1200
gaacctaag  ctccaaaaa  gtggtactg  aggagtgga  actgctgct  caggcggtg  1260
ctttgatat  tctaatttg  accgactag  caaatcaga  gtggagctg  tgcaactgg  1320
catcgatgg  gtaaactat  tgattgatt  tgaacggcg  ctggagaga  gccaggata  1380
ccgcatccc  acacctgtc  tccacacca  gcattaact  cccatcgcc  gctgatgac  1440
caagattcc  aggagtttt  ctcattcta  tgatggccc  ttctacttg  tctggacct  1500
cccccgcat  ccctgcctc  atcctagt  1528



<210> 9715
<211> 417
<212> PRT
<213> Homo sapiens
<308> NP_066270
<400> 9715

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
  1               5                  10                  15
Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
             20                  25                  30
Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
         35                  40                  45
Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
     50                  55                  60
Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
 65                  70                  75                  80
Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                 85                  90                  95
Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
             100                105                110
Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
         115                120                125
Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
     130                135                140
Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
 145                150                155                160
Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                 165                170                175
Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
             180                185                190
Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
         195                200                205
Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
     210                215                220
Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
 225                230                235                240
Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys 
                 245                250                255
Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser 
             260                265                270
Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg 
         275                280                285
Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu Phe 
     290                295                300
Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu 
 305                310                315                320
Gly Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Leu Leu Ser 
                 325                330                335
Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln Lys 
             340                345                350
Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Thr Gly Gly Val Phe Asp 
         355                360                365
Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val Gln 
     370                375                380
Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg Leu 
 385                390                395                400
Glu Arg Gly Gln Asp Ile Arg Ile Pro Thr Pro Val Ile His Thr Lys 
                 405                410                415
His 
             420



<210> 9716
<211> 1547
<212> DNA
<213> Rattus norvegicus
<308> X59859
<400> 9716

gcacaagtt  cctgggctg  accatttga  cagagagga  tatttgact  catgctaga  60
gatgaggcc  ctggcataa  cccttacga  cctgacaat  ccctgatat  tatgtgccc  120
taccgatgc  aatgccatc  ccgagtggt  cagtgttct  atctgggtc  ggacaaagt  180
ccctgggaa  ttccacctg  cacaacatt  ctagacctg  aaaacaaca  aataacaga  240
atcaaagag  gggccttta  gaacctgaa  gacttgcat  ccttgatcc  tgtcaacaa  300
aagatcagc  agatcagcc  agaggcatt  aaacctcta  tgaagttgg  aaggcttta  360
ctgtctaag  accacctaa  ggagctgcc  gaaaaattg  ccaaaacac  ccaggagct  420
cgactccac  acaatgaga  caccaaact  aagaaatct  tgttcaatg  actgaaccg  480
atgattgtc  tagaactgg  cggcaaccc  ctgaaaaac  ctgggattg  aaatggagc  540
ttgcaggga  tgaagggtc  cggatacat  cgcatctca  acaccaaca  aactgctat  600
cctcaaggt  tgcccactt  tatcagtga  ctgcatctg  atggcaaca  gatagccaa  660
gttgatgca  ccagcctga  aggaatgtc  aatttgtct  agctgggtt  gagcttcaa  720
agcatcacc  ttgtggaaa  tggcagtct  gctaatgtt  ctcatctga  ggagctcca  780
ttggacaac  acaaactcc  cagagtgcc  gctgggctg  cacagcata  atatgtcca  840
gtcgtctac  ttcataaca  caacatctc  gaagttggg  agcatgact  ctgcctccc  900
tcataccag  ctaggaaga  ttcctacac  gccgtgagt  tttatagca  ccctgtccg  960
tattggcaa  ttcacccac  caccttcag  tgtgtcttc  ggcgctcta  cattcaact  1020
gggaactac  agtaactcc  aaacagcct  atttttata  tcgggaaca  aaaaaccaa  1080
ctgtcaata  tattgctaa  aagaaaaaa  tattttgaa  aagaaagaa  gctagattc  1140
ggaaattca  gtatagcgc  gatgccttt  ccgtatgac  tatcatgca  caagccaaa  1200
atacagatt  aataattac  tacaataaa  atattttat  tgtagtatt  agaatcact  1260
ttaaaattt  ctgtagatg  gaactgagg  atcgaagtc  gatgtaatc  tagatgtca  1320
catttaata  agctaaaag  aacagaata  aaagtcttc  gtaattcat  gagctaaat  1380
gactctttt  acataaagt  aaatgtaga  ctctagcaa  gtattaatc  cctttatta  1440
tggtaaagt  ttatttgaa  atctaagtt  aacatgggc  atgtaaaat  ttcactgtc  1500
tactgaaaa  caataaaat  taaaaaatg  attcaaaaa  aaaaaaa  1547



<210> 9717
<211> 354
<212> PRT
<213> Rattus norvegicus
<308> Q01129
<400> 9717

Met Lys Ala Thr Leu Val Leu Phe Leu Leu Ala Gln Val Ser Trp Ala 
  1               5                  10                  15
Gly Pro Phe Glu Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
             20                  25                  30
Ala Ser Gly Ile Ile Pro Tyr Asp Pro Asp Asn Pro Leu Ile Ser Met 
         35                  40                  45
Cys Pro Tyr Arg Cys Gln Cys His Leu Arg Val Val Gln Cys Ser Asp 
     50                  55                  60
Leu Gly Leu Asp Lys Val Pro Trp Glu Phe Pro Pro Asp Thr Thr Leu 
 65                  70                  75                  80
Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile Lys Glu Gly Ala Phe 
                 85                  90                  95
Lys Asn Leu Lys Asp Leu His Thr Leu Ile Leu Val Asn Asn Lys Ile 
             100                105                110
Ser Lys Ile Ser Pro Glu Ala Phe Lys Pro Leu Val Lys Leu Glu Arg 
         115                120                125
Leu Tyr Leu Ser Lys Asn His Leu Lys Glu Leu Pro Glu Lys Leu Pro 
     130                135                140
Lys Thr Leu Gln Glu Leu Arg Leu His Asp Asn Glu Ile Thr Lys Leu 
 145                150                155                160
Lys Lys Ser Val Phe Asn Gly Leu Asn Arg Met Ile Val Ile Glu Leu 
                 165                170                175
Gly Gly Asn Pro Leu Lys Asn Ser Gly Ile Glu Asn Gly Ala Leu Gln 
             180                185                190
Gly Met Lys Gly Leu Gly Tyr Ile Arg Ile Ser Asp Thr Asn Ile Thr 
         195                200                205
Ala Ile Pro Gln Gly Leu Pro Thr Ser Ile Ser Glu Leu His Leu Asp 
     210                215                220
Gly Asn Lys Ile Ala Lys Val Asp Ala Ala Ser Leu Lys Gly Met Ser 
 225                230                235                240
Asn Leu Ser Lys Leu Gly Leu Ser Phe Asn Ser Ile Thr Val Val Glu 
                 245                250                255
Asn Gly Ser Leu Ala Asn Val Pro His Leu Arg Glu Leu His Leu Asp 
             260                265                270
Asn Asn Lys Leu Leu Arg Val Pro Ala Gly Leu Ala Gln His Lys Tyr 
         275                280                285
Val Gln Val Val Tyr Leu His Asn Asn Asn Ile Ser Glu Val Gly Gln 
     290                295                300
His Asp Phe Cys Leu Pro Ser Tyr Gln Thr Arg Lys Thr Ser Tyr Thr 
 305                310                315                320
Ala Val Ser Leu Tyr Ser Asn Pro Val Arg Tyr Trp Gln Ile His Pro 
                 325                330                335
His Thr Phe Arg Cys Val Phe Gly Arg Ser Thr Ile Gln Leu Gly Asn 
             340                345                350
Tyr Lys 
         355



<210> 9718
<211> 1751
<212> DNA
<213> Homo sapiens
<308> NM_001920
<400> 9718

tttaactgt  ctatggagt  gaagcagga  gttttcaac  tagtcacag  gcagcacct  60
ccccctcct  ctttccaca  ctgcaaact  ttttacttg  gctgaatat  tagtgtaat  120
acatctcag  tttgagggc  cctgtggca  attcccgga  taaaaggtt  cctggttgt  180
aaaatacat  agataaatc  tgaaggcca  tatcatcct  cttctgctt  cacaagttt  240
ctgggctgg  ccgtttcaa  agagaggct  atttgactt  atgctagaa  atgaggctt  300
tgggatagg  ccagaagtt  ctgatgacc  cgacttcga  ccctcccta  gcccagtgt  360
ccccttccg  tgtcaatgc  atcttcgag  ggtccagtg  tctgatttg  gtctggaca  420
agtgccaaa  gatcttccc  ctgacacaa  tctgctaga  ctgcaaaac  acaaaataa  480
cgaaatcaa  gatggagac  ttaagaacc  gaagaacct  cacgcattg  ttcttgtca  540
caataaaat  agcaaagtt  gtcctggag  atttacacc  ttggtgaag  tggaacgac  600
ttatctgtc  aagaatcag  tgaaggaat  gccagaaaa  atgcccaaa  ctcttcagg  660
gctgcgtgc  catgagaat  agatcacca  agtgcgaaa  gttactttc  atggactga  720
ccagatgat  gtcatagaa  tgggcacca  tccgctgaa  agctcagga  ttgaaaatg  780
ggctttcca  ggaatgaag  agctctcct  catccgcat  gctgatacc  atatcacca  840
cattcctca  ggtcttcct  cttccctta  ggaattaca  cttgatggc  acaaaatca  900
cagagttga  gcagctagc  tgaaaggac  gaataattt  gctaagttg  gattgagtt  960
caacagcat  tctgctgtt  acaatggct  tctggccaa  acgcctcat  tgagggagc  1020
tcacttgga  aacaacaag  ttaccagag  acctggtgg  ctggcagag  ataagtaca  1080
ccaggttgt  taccttcat  acaacaata  ctctgtagt  ggatcaagt  acttctgcc  1140
acctggaca  aacaccaaa  aggcttctt  ttcgggtgt  agtcttttc  gcaacccgg  1200
ccagtactg  gagatacag  catccacct  cagatgtgt  tacgtgcgc  ctgccattc  1260
actcggaaa  tataagtaa  tctcaagaa  gccctcatt  ttataacct  gcaaaatct  1320
gttaatgtc  ttgctaaaa  ataaataaa  gctagatac  ggaaaccta  ctgcaatgt  1380
gatgtttta  ccacatgac  tattatgca  aaagccaaa  ttccagttt  agtaattgc  1440
tacaataaa  agaaatttt  cctgccatt  tcagaatca  cttttgaag  tttctgttg  1500
tgttaactg  gctactaga  atattctta  ttcactaaa  gtaaaattt  gagtaaata  1560
atatgtcaa  atttagtaa  gcttttctt  tttaatttc  aggaaaaaa  aaaaagagt  1620
tgagtcttc  gtaattcat  gagcagtta  ctcatttga  ataaagtca  atgccaaac  1680
ctagctctg  attaatccc  atcattact  gtaaagcct  atttgaatg  gtgaattca  1740
tacaggcta  g  1751



<210> 9719
<211> 359
<212> PRT
<213> Homo sapiens
<308> P07585
<400> 9719

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
  1               5                  10                  15
Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
             20                  25                  30
Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
         35                  40                  45
Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
     50                  55                  60
Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
 65                  70                  75                  80
Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                 85                  90                  95
Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
             100                105                110
Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
         115                120                125
Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
     130                135                140
Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
 145                150                155                160
Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                 165                170                175
Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
             180                185                190
Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
         195                200                205
Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
     210                215                220
Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
 225                230                235                240
Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                 245                250                255
Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
             260                265                270
Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
         275                280                285
Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
     290                295                300
Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
 305                310                315                320
Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
                 325                330                335
Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
             340                345                350
Ile Gln Leu Gly Asn Tyr Lys 
         355



<210> 9720
<211> 1547
<212> DNA
<213> Rattus norvegicus
<308> X59859
<400> 9720

gcacaagtt  cctgggctg  accatttga  cagagagga  tatttgact  catgctaga  60
gatgaggcc  ctggcataa  cccttacga  cctgacaat  ccctgatat  tatgtgccc  120
taccgatgc  aatgccatc  ccgagtggt  cagtgttct  atctgggtc  ggacaaagt  180
ccctgggaa  ttccacctg  cacaacatt  ctagacctg  aaaacaaca  aataacaga  240
atcaaagag  gggccttta  gaacctgaa  gacttgcat  ccttgatcc  tgtcaacaa  300
aagatcagc  agatcagcc  agaggcatt  aaacctcta  tgaagttgg  aaggcttta  360
ctgtctaag  accacctaa  ggagctgcc  gaaaaattg  ccaaaacac  ccaggagct  420
cgactccac  acaatgaga  caccaaact  aagaaatct  tgttcaatg  actgaaccg  480
atgattgtc  tagaactgg  cggcaaccc  ctgaaaaac  ctgggattg  aaatggagc  540
ttgcaggga  tgaagggtc  cggatacat  cgcatctca  acaccaaca  aactgctat  600
cctcaaggt  tgcccactt  tatcagtga  ctgcatctg  atggcaaca  gatagccaa  660
gttgatgca  ccagcctga  aggaatgtc  aatttgtct  agctgggtt  gagcttcaa  720
agcatcacc  ttgtggaaa  tggcagtct  gctaatgtt  ctcatctga  ggagctcca  780
ttggacaac  acaaactcc  cagagtgcc  gctgggctg  cacagcata  atatgtcca  840
gtcgtctac  ttcataaca  caacatctc  gaagttggg  agcatgact  ctgcctccc  900
tcataccag  ctaggaaga  ttcctacac  gccgtgagt  tttatagca  ccctgtccg  960
tattggcaa  ttcacccac  caccttcag  tgtgtcttc  ggcgctcta  cattcaact  1020
gggaactac  agtaactcc  aaacagcct  atttttata  tcgggaaca  aaaaaccaa  1080
ctgtcaata  tattgctaa  aagaaaaaa  tattttgaa  aagaaagaa  gctagattc  1140
ggaaattca  gtatagcgc  gatgccttt  ccgtatgac  tatcatgca  caagccaaa  1200
atacagatt  aataattac  tacaataaa  atattttat  tgtagtatt  agaatcact  1260
ttaaaattt  ctgtagatg  gaactgagg  atcgaagtc  gatgtaatc  tagatgtca  1320
catttaata  agctaaaag  aacagaata  aaagtcttc  gtaattcat  gagctaaat  1380
gactctttt  acataaagt  aaatgtaga  ctctagcaa  gtattaatc  cctttatta  1440
tggtaaagt  ttatttgaa  atctaagtt  aacatgggc  atgtaaaat  ttcactgtc  1500
tactgaaaa  caataaaat  taaaaaatg  attcaaaaa  aaaaaaa  1547



<210> 9721
<211> 354
<212> PRT
<213> Rattus norvegicus
<308> Q01129
<400> 9721

Met Lys Ala Thr Leu Val Leu Phe Leu Leu Ala Gln Val Ser Trp Ala 
  1               5                  10                  15
Gly Pro Phe Glu Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
             20                  25                  30
Ala Ser Gly Ile Ile Pro Tyr Asp Pro Asp Asn Pro Leu Ile Ser Met 
         35                  40                  45
Cys Pro Tyr Arg Cys Gln Cys His Leu Arg Val Val Gln Cys Ser Asp 
     50                  55                  60
Leu Gly Leu Asp Lys Val Pro Trp Glu Phe Pro Pro Asp Thr Thr Leu 
 65                  70                  75                  80
Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile Lys Glu Gly Ala Phe 
                 85                  90                  95
Lys Asn Leu Lys Asp Leu His Thr Leu Ile Leu Val Asn Asn Lys Ile 
             100                105                110
Ser Lys Ile Ser Pro Glu Ala Phe Lys Pro Leu Val Lys Leu Glu Arg 
         115                120                125
Leu Tyr Leu Ser Lys Asn His Leu Lys Glu Leu Pro Glu Lys Leu Pro 
     130                135                140
Lys Thr Leu Gln Glu Leu Arg Leu His Asp Asn Glu Ile Thr Lys Leu 
 145                150                155                160
Lys Lys Ser Val Phe Asn Gly Leu Asn Arg Met Ile Val Ile Glu Leu 
                 165                170                175
Gly Gly Asn Pro Leu Lys Asn Ser Gly Ile Glu Asn Gly Ala Leu Gln 
             180                185                190
Gly Met Lys Gly Leu Gly Tyr Ile Arg Ile Ser Asp Thr Asn Ile Thr 
         195                200                205
Ala Ile Pro Gln Gly Leu Pro Thr Ser Ile Ser Glu Leu His Leu Asp 
     210                215                220
Gly Asn Lys Ile Ala Lys Val Asp Ala Ala Ser Leu Lys Gly Met Ser 
 225                230                235                240
Asn Leu Ser Lys Leu Gly Leu Ser Phe Asn Ser Ile Thr Val Val Glu 
                 245                250                255
Asn Gly Ser Leu Ala Asn Val Pro His Leu Arg Glu Leu His Leu Asp 
             260                265                270
Asn Asn Lys Leu Leu Arg Val Pro Ala Gly Leu Ala Gln His Lys Tyr 
         275                280                285
Val Gln Val Val Tyr Leu His Asn Asn Asn Ile Ser Glu Val Gly Gln 
     290                295                300
His Asp Phe Cys Leu Pro Ser Tyr Gln Thr Arg Lys Thr Ser Tyr Thr 
 305                310                315                320
Ala Val Ser Leu Tyr Ser Asn Pro Val Arg Tyr Trp Gln Ile His Pro 
                 325                330                335
His Thr Phe Arg Cys Val Phe Gly Arg Ser Thr Ile Gln Leu Gly Asn 
             340                345                350
Tyr Lys 
         355



<210> 9722
<211> 1751
<212> DNA
<213> Homo sapiens
<308> NM_001920
<400> 9722

tttaactgt  ctatggagt  gaagcagga  gttttcaac  tagtcacag  gcagcacct  60
ccccctcct  ctttccaca  ctgcaaact  ttttacttg  gctgaatat  tagtgtaat  120
acatctcag  tttgagggc  cctgtggca  attcccgga  taaaaggtt  cctggttgt  180
aaaatacat  agataaatc  tgaaggcca  tatcatcct  cttctgctt  cacaagttt  240
ctgggctgg  ccgtttcaa  agagaggct  atttgactt  atgctagaa  atgaggctt  300
tgggatagg  ccagaagtt  ctgatgacc  cgacttcga  ccctcccta  gcccagtgt  360
ccccttccg  tgtcaatgc  atcttcgag  ggtccagtg  tctgatttg  gtctggaca  420
agtgccaaa  gatcttccc  ctgacacaa  tctgctaga  ctgcaaaac  acaaaataa  480
cgaaatcaa  gatggagac  ttaagaacc  gaagaacct  cacgcattg  ttcttgtca  540
caataaaat  agcaaagtt  gtcctggag  atttacacc  ttggtgaag  tggaacgac  600
ttatctgtc  aagaatcag  tgaaggaat  gccagaaaa  atgcccaaa  ctcttcagg  660
gctgcgtgc  catgagaat  agatcacca  agtgcgaaa  gttactttc  atggactga  720
ccagatgat  gtcatagaa  tgggcacca  tccgctgaa  agctcagga  ttgaaaatg  780
ggctttcca  ggaatgaag  agctctcct  catccgcat  gctgatacc  atatcacca  840
cattcctca  ggtcttcct  cttccctta  ggaattaca  cttgatggc  acaaaatca  900
cagagttga  gcagctagc  tgaaaggac  gaataattt  gctaagttg  gattgagtt  960
caacagcat  tctgctgtt  acaatggct  tctggccaa  acgcctcat  tgagggagc  1020
tcacttgga  aacaacaag  ttaccagag  acctggtgg  ctggcagag  ataagtaca  1080
ccaggttgt  taccttcat  acaacaata  ctctgtagt  ggatcaagt  acttctgcc  1140
acctggaca  aacaccaaa  aggcttctt  ttcgggtgt  agtcttttc  gcaacccgg  1200
ccagtactg  gagatacag  catccacct  cagatgtgt  tacgtgcgc  ctgccattc  1260
actcggaaa  tataagtaa  tctcaagaa  gccctcatt  ttataacct  gcaaaatct  1320
gttaatgtc  ttgctaaaa  ataaataaa  gctagatac  ggaaaccta  ctgcaatgt  1380
gatgtttta  ccacatgac  tattatgca  aaagccaaa  ttccagttt  agtaattgc  1440
tacaataaa  agaaatttt  cctgccatt  tcagaatca  cttttgaag  tttctgttg  1500
tgttaactg  gctactaga  atattctta  ttcactaaa  gtaaaattt  gagtaaata  1560
atatgtcaa  atttagtaa  gcttttctt  tttaatttc  aggaaaaaa  aaaaagagt  1620
tgagtcttc  gtaattcat  gagcagtta  ctcatttga  ataaagtca  atgccaaac  1680
ctagctctg  attaatccc  atcattact  gtaaagcct  atttgaatg  gtgaattca  1740
tacaggcta  g  1751



<210> 9723
<211> 359
<212> PRT
<213> Homo sapiens
<308> P07585
<400> 9723

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
  1               5                  10                  15
Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
             20                  25                  30
Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
         35                  40                  45
Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
     50                  55                  60
Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
 65                  70                  75                  80
Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                 85                  90                  95
Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
             100                105                110
Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
         115                120                125
Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
     130                135                140
Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
 145                150                155                160
Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                 165                170                175
Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
             180                185                190
Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
         195                200                205
Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
     210                215                220
Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
 225                230                235                240
Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                 245                250                255
Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
             260                265                270
Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
         275                280                285
Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
     290                295                300
Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
 305                310                315                320
Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
                 325                330                335
Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
             340                345                350
Ile Gln Leu Gly Asn Tyr Lys 
         355



<210> 9724
<211> 1547
<212> DNA
<213> Rattus norvegicus
<308> X59859
<400> 9724

gcacaagtt  cctgggctg  accatttga  cagagagga  tatttgact  catgctaga  60
gatgaggcc  ctggcataa  cccttacga  cctgacaat  ccctgatat  tatgtgccc  120
taccgatgc  aatgccatc  ccgagtggt  cagtgttct  atctgggtc  ggacaaagt  180
ccctgggaa  ttccacctg  cacaacatt  ctagacctg  aaaacaaca  aataacaga  240
atcaaagag  gggccttta  gaacctgaa  gacttgcat  ccttgatcc  tgtcaacaa  300
aagatcagc  agatcagcc  agaggcatt  aaacctcta  tgaagttgg  aaggcttta  360
ctgtctaag  accacctaa  ggagctgcc  gaaaaattg  ccaaaacac  ccaggagct  420
cgactccac  acaatgaga  caccaaact  aagaaatct  tgttcaatg  actgaaccg  480
atgattgtc  tagaactgg  cggcaaccc  ctgaaaaac  ctgggattg  aaatggagc  540
ttgcaggga  tgaagggtc  cggatacat  cgcatctca  acaccaaca  aactgctat  600
cctcaaggt  tgcccactt  tatcagtga  ctgcatctg  atggcaaca  gatagccaa  660
gttgatgca  ccagcctga  aggaatgtc  aatttgtct  agctgggtt  gagcttcaa  720
agcatcacc  ttgtggaaa  tggcagtct  gctaatgtt  ctcatctga  ggagctcca  780
ttggacaac  acaaactcc  cagagtgcc  gctgggctg  cacagcata  atatgtcca  840
gtcgtctac  ttcataaca  caacatctc  gaagttggg  agcatgact  ctgcctccc  900
tcataccag  ctaggaaga  ttcctacac  gccgtgagt  tttatagca  ccctgtccg  960
tattggcaa  ttcacccac  caccttcag  tgtgtcttc  ggcgctcta  cattcaact  1020
gggaactac  agtaactcc  aaacagcct  atttttata  tcgggaaca  aaaaaccaa  1080
ctgtcaata  tattgctaa  aagaaaaaa  tattttgaa  aagaaagaa  gctagattc  1140
ggaaattca  gtatagcgc  gatgccttt  ccgtatgac  tatcatgca  caagccaaa  1200
atacagatt  aataattac  tacaataaa  atattttat  tgtagtatt  agaatcact  1260
ttaaaattt  ctgtagatg  gaactgagg  atcgaagtc  gatgtaatc  tagatgtca  1320
catttaata  agctaaaag  aacagaata  aaagtcttc  gtaattcat  gagctaaat  1380
gactctttt  acataaagt  aaatgtaga  ctctagcaa  gtattaatc  cctttatta  1440
tggtaaagt  ttatttgaa  atctaagtt  aacatgggc  atgtaaaat  ttcactgtc  1500
tactgaaaa  caataaaat  taaaaaatg  attcaaaaa  aaaaaaa  1547



<210> 9725
<211> 354
<212> PRT
<213> Rattus norvegicus
<308> Q01129
<400> 9725

Met Lys Ala Thr Leu Val Leu Phe Leu Leu Ala Gln Val Ser Trp Ala 
  1               5                  10                  15
Gly Pro Phe Glu Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
             20                  25                  30
Ala Ser Gly Ile Ile Pro Tyr Asp Pro Asp Asn Pro Leu Ile Ser Met 
         35                  40                  45
Cys Pro Tyr Arg Cys Gln Cys His Leu Arg Val Val Gln Cys Ser Asp 
     50                  55                  60
Leu Gly Leu Asp Lys Val Pro Trp Glu Phe Pro Pro Asp Thr Thr Leu 
 65                  70                  75                  80
Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile Lys Glu Gly Ala Phe 
                 85                  90                  95
Lys Asn Leu Lys Asp Leu His Thr Leu Ile Leu Val Asn Asn Lys Ile 
             100                105                110
Ser Lys Ile Ser Pro Glu Ala Phe Lys Pro Leu Val Lys Leu Glu Arg 
         115                120                125
Leu Tyr Leu Ser Lys Asn His Leu Lys Glu Leu Pro Glu Lys Leu Pro 
     130                135                140
Lys Thr Leu Gln Glu Leu Arg Leu His Asp Asn Glu Ile Thr Lys Leu 
 145                150                155                160
Lys Lys Ser Val Phe Asn Gly Leu Asn Arg Met Ile Val Ile Glu Leu 
                 165                170                175
Gly Gly Asn Pro Leu Lys Asn Ser Gly Ile Glu Asn Gly Ala Leu Gln 
             180                185                190
Gly Met Lys Gly Leu Gly Tyr Ile Arg Ile Ser Asp Thr Asn Ile Thr 
         195                200                205
Ala Ile Pro Gln Gly Leu Pro Thr Ser Ile Ser Glu Leu His Leu Asp 
     210                215                220
Gly Asn Lys Ile Ala Lys Val Asp Ala Ala Ser Leu Lys Gly Met Ser 
 225                230                235                240
Asn Leu Ser Lys Leu Gly Leu Ser Phe Asn Ser Ile Thr Val Val Glu 
                 245                250                255
Asn Gly Ser Leu Ala Asn Val Pro His Leu Arg Glu Leu His Leu Asp 
             260                265                270
Asn Asn Lys Leu Leu Arg Val Pro Ala Gly Leu Ala Gln His Lys Tyr 
         275                280                285
Val Gln Val Val Tyr Leu His Asn Asn Asn Ile Ser Glu Val Gly Gln 
     290                295                300
His Asp Phe Cys Leu Pro Ser Tyr Gln Thr Arg Lys Thr Ser Tyr Thr 
 305                310                315                320
Ala Val Ser Leu Tyr Ser Asn Pro Val Arg Tyr Trp Gln Ile His Pro 
                 325                330                335
His Thr Phe Arg Cys Val Phe Gly Arg Ser Thr Ile Gln Leu Gly Asn 
             340                345                350
Tyr Lys 
         355



<210> 9726
<211> 1751
<212> DNA
<213> Homo sapiens
<308> NM_001920
<400> 9726

tttaactgt  ctatggagt  gaagcagga  gttttcaac  tagtcacag  gcagcacct  60
ccccctcct  ctttccaca  ctgcaaact  ttttacttg  gctgaatat  tagtgtaat  120
acatctcag  tttgagggc  cctgtggca  attcccgga  taaaaggtt  cctggttgt  180
aaaatacat  agataaatc  tgaaggcca  tatcatcct  cttctgctt  cacaagttt  240
ctgggctgg  ccgtttcaa  agagaggct  atttgactt  atgctagaa  atgaggctt  300
tgggatagg  ccagaagtt  ctgatgacc  cgacttcga  ccctcccta  gcccagtgt  360
ccccttccg  tgtcaatgc  atcttcgag  ggtccagtg  tctgatttg  gtctggaca  420
agtgccaaa  gatcttccc  ctgacacaa  tctgctaga  ctgcaaaac  acaaaataa  480
cgaaatcaa  gatggagac  ttaagaacc  gaagaacct  cacgcattg  ttcttgtca  540
caataaaat  agcaaagtt  gtcctggag  atttacacc  ttggtgaag  tggaacgac  600
ttatctgtc  aagaatcag  tgaaggaat  gccagaaaa  atgcccaaa  ctcttcagg  660
gctgcgtgc  catgagaat  agatcacca  agtgcgaaa  gttactttc  atggactga  720
ccagatgat  gtcatagaa  tgggcacca  tccgctgaa  agctcagga  ttgaaaatg  780
ggctttcca  ggaatgaag  agctctcct  catccgcat  gctgatacc  atatcacca  840
cattcctca  ggtcttcct  cttccctta  ggaattaca  cttgatggc  acaaaatca  900
cagagttga  gcagctagc  tgaaaggac  gaataattt  gctaagttg  gattgagtt  960
caacagcat  tctgctgtt  acaatggct  tctggccaa  acgcctcat  tgagggagc  1020
tcacttgga  aacaacaag  ttaccagag  acctggtgg  ctggcagag  ataagtaca  1080
ccaggttgt  taccttcat  acaacaata  ctctgtagt  ggatcaagt  acttctgcc  1140
acctggaca  aacaccaaa  aggcttctt  ttcgggtgt  agtcttttc  gcaacccgg  1200
ccagtactg  gagatacag  catccacct  cagatgtgt  tacgtgcgc  ctgccattc  1260
actcggaaa  tataagtaa  tctcaagaa  gccctcatt  ttataacct  gcaaaatct  1320
gttaatgtc  ttgctaaaa  ataaataaa  gctagatac  ggaaaccta  ctgcaatgt  1380
gatgtttta  ccacatgac  tattatgca  aaagccaaa  ttccagttt  agtaattgc  1440
tacaataaa  agaaatttt  cctgccatt  tcagaatca  cttttgaag  tttctgttg  1500
tgttaactg  gctactaga  atattctta  ttcactaaa  gtaaaattt  gagtaaata  1560
atatgtcaa  atttagtaa  gcttttctt  tttaatttc  aggaaaaaa  aaaaagagt  1620
tgagtcttc  gtaattcat  gagcagtta  ctcatttga  ataaagtca  atgccaaac  1680
ctagctctg  attaatccc  atcattact  gtaaagcct  atttgaatg  gtgaattca  1740
tacaggcta  g  1751



<210> 9727
<211> 359
<212> PRT
<213> Homo sapiens
<308> P07585
<400> 9727

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
  1               5                  10                  15
Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
             20                  25                  30
Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
         35                  40                  45
Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
     50                  55                  60
Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
 65                  70                  75                  80
Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                 85                  90                  95
Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
             100                105                110
Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
         115                120                125
Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
     130                135                140
Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
 145                150                155                160
Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                 165                170                175
Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
             180                185                190
Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
         195                200                205
Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
     210                215                220
Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
 225                230                235                240
Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                 245                250                255
Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
             260                265                270
Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
         275                280                285
Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
     290                295                300
Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
 305                310                315                320
Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
                 325                330                335
Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
             340                345                350
Ile Gln Leu Gly Asn Tyr Lys 
         355



<210> 9728
<211> 1547
<212> DNA
<213> Rattus norvegicus
<308> X59859
<400> 9728

gcacaagtt  cctgggctg  accatttga  cagagagga  tatttgact  catgctaga  60
gatgaggcc  ctggcataa  cccttacga  cctgacaat  ccctgatat  tatgtgccc  120
taccgatgc  aatgccatc  ccgagtggt  cagtgttct  atctgggtc  ggacaaagt  180
ccctgggaa  ttccacctg  cacaacatt  ctagacctg  aaaacaaca  aataacaga  240
atcaaagag  gggccttta  gaacctgaa  gacttgcat  ccttgatcc  tgtcaacaa  300
aagatcagc  agatcagcc  agaggcatt  aaacctcta  tgaagttgg  aaggcttta  360
ctgtctaag  accacctaa  ggagctgcc  gaaaaattg  ccaaaacac  ccaggagct  420
cgactccac  acaatgaga  caccaaact  aagaaatct  tgttcaatg  actgaaccg  480
atgattgtc  tagaactgg  cggcaaccc  ctgaaaaac  ctgggattg  aaatggagc  540
ttgcaggga  tgaagggtc  cggatacat  cgcatctca  acaccaaca  aactgctat  600
cctcaaggt  tgcccactt  tatcagtga  ctgcatctg  atggcaaca  gatagccaa  660
gttgatgca  ccagcctga  aggaatgtc  aatttgtct  agctgggtt  gagcttcaa  720
agcatcacc  ttgtggaaa  tggcagtct  gctaatgtt  ctcatctga  ggagctcca  780
ttggacaac  acaaactcc  cagagtgcc  gctgggctg  cacagcata  atatgtcca  840
gtcgtctac  ttcataaca  caacatctc  gaagttggg  agcatgact  ctgcctccc  900
tcataccag  ctaggaaga  ttcctacac  gccgtgagt  tttatagca  ccctgtccg  960
tattggcaa  ttcacccac  caccttcag  tgtgtcttc  ggcgctcta  cattcaact  1020
gggaactac  agtaactcc  aaacagcct  atttttata  tcgggaaca  aaaaaccaa  1080
ctgtcaata  tattgctaa  aagaaaaaa  tattttgaa  aagaaagaa  gctagattc  1140
ggaaattca  gtatagcgc  gatgccttt  ccgtatgac  tatcatgca  caagccaaa  1200
atacagatt  aataattac  tacaataaa  atattttat  tgtagtatt  agaatcact  1260
ttaaaattt  ctgtagatg  gaactgagg  atcgaagtc  gatgtaatc  tagatgtca  1320
catttaata  agctaaaag  aacagaata  aaagtcttc  gtaattcat  gagctaaat  1380
gactctttt  acataaagt  aaatgtaga  ctctagcaa  gtattaatc  cctttatta  1440
tggtaaagt  ttatttgaa  atctaagtt  aacatgggc  atgtaaaat  ttcactgtc  1500
tactgaaaa  caataaaat  taaaaaatg  attcaaaaa  aaaaaaa  1547



<210> 9729
<211> 354
<212> PRT
<213> Rattus norvegicus
<308> Q01129
<400> 9729

Met Lys Ala Thr Leu Val Leu Phe Leu Leu Ala Gln Val Ser Trp Ala 
  1               5                  10                  15
Gly Pro Phe Glu Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
             20                  25                  30
Ala Ser Gly Ile Ile Pro Tyr Asp Pro Asp Asn Pro Leu Ile Ser Met 
         35                  40                  45
Cys Pro Tyr Arg Cys Gln Cys His Leu Arg Val Val Gln Cys Ser Asp 
     50                  55                  60
Leu Gly Leu Asp Lys Val Pro Trp Glu Phe Pro Pro Asp Thr Thr Leu 
 65                  70                  75                  80
Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile Lys Glu Gly Ala Phe 
                 85                  90                  95
Lys Asn Leu Lys Asp Leu His Thr Leu Ile Leu Val Asn Asn Lys Ile 
             100                105                110
Ser Lys Ile Ser Pro Glu Ala Phe Lys Pro Leu Val Lys Leu Glu Arg 
         115                120                125
Leu Tyr Leu Ser Lys Asn His Leu Lys Glu Leu Pro Glu Lys Leu Pro 
     130                135                140
Lys Thr Leu Gln Glu Leu Arg Leu His Asp Asn Glu Ile Thr Lys Leu 
 145                150                155                160
Lys Lys Ser Val Phe Asn Gly Leu Asn Arg Met Ile Val Ile Glu Leu 
                 165                170                175
Gly Gly Asn Pro Leu Lys Asn Ser Gly Ile Glu Asn Gly Ala Leu Gln 
             180                185                190
Gly Met Lys Gly Leu Gly Tyr Ile Arg Ile Ser Asp Thr Asn Ile Thr 
         195                200                205
Ala Ile Pro Gln Gly Leu Pro Thr Ser Ile Ser Glu Leu His Leu Asp 
     210                215                220
Gly Asn Lys Ile Ala Lys Val Asp Ala Ala Ser Leu Lys Gly Met Ser 
 225                230                235                240
Asn Leu Ser Lys Leu Gly Leu Ser Phe Asn Ser Ile Thr Val Val Glu 
                 245                250                255
Asn Gly Ser Leu Ala Asn Val Pro His Leu Arg Glu Leu His Leu Asp 
             260                265                270
Asn Asn Lys Leu Leu Arg Val Pro Ala Gly Leu Ala Gln His Lys Tyr 
         275                280                285
Val Gln Val Val Tyr Leu His Asn Asn Asn Ile Ser Glu Val Gly Gln 
     290                295                300
His Asp Phe Cys Leu Pro Ser Tyr Gln Thr Arg Lys Thr Ser Tyr Thr 
 305                310                315                320
Ala Val Ser Leu Tyr Ser Asn Pro Val Arg Tyr Trp Gln Ile His Pro 
                 325                330                335
His Thr Phe Arg Cys Val Phe Gly Arg Ser Thr Ile Gln Leu Gly Asn 
             340                345                350
Tyr Lys 
         355



<210> 9730
<211> 1751
<212> DNA
<213> Homo sapiens
<308> NM_001920
<400> 9730

tttaactgt  ctatggagt  gaagcagga  gttttcaac  tagtcacag  gcagcacct  60
ccccctcct  ctttccaca  ctgcaaact  ttttacttg  gctgaatat  tagtgtaat  120
acatctcag  tttgagggc  cctgtggca  attcccgga  taaaaggtt  cctggttgt  180
aaaatacat  agataaatc  tgaaggcca  tatcatcct  cttctgctt  cacaagttt  240
ctgggctgg  ccgtttcaa  agagaggct  atttgactt  atgctagaa  atgaggctt  300
tgggatagg  ccagaagtt  ctgatgacc  cgacttcga  ccctcccta  gcccagtgt  360
ccccttccg  tgtcaatgc  atcttcgag  ggtccagtg  tctgatttg  gtctggaca  420
agtgccaaa  gatcttccc  ctgacacaa  tctgctaga  ctgcaaaac  acaaaataa  480
cgaaatcaa  gatggagac  ttaagaacc  gaagaacct  cacgcattg  ttcttgtca  540
caataaaat  agcaaagtt  gtcctggag  atttacacc  ttggtgaag  tggaacgac  600
ttatctgtc  aagaatcag  tgaaggaat  gccagaaaa  atgcccaaa  ctcttcagg  660
gctgcgtgc  catgagaat  agatcacca  agtgcgaaa  gttactttc  atggactga  720
ccagatgat  gtcatagaa  tgggcacca  tccgctgaa  agctcagga  ttgaaaatg  780
ggctttcca  ggaatgaag  agctctcct  catccgcat  gctgatacc  atatcacca  840
cattcctca  ggtcttcct  cttccctta  ggaattaca  cttgatggc  acaaaatca  900
cagagttga  gcagctagc  tgaaaggac  gaataattt  gctaagttg  gattgagtt  960
caacagcat  tctgctgtt  acaatggct  tctggccaa  acgcctcat  tgagggagc  1020
tcacttgga  aacaacaag  ttaccagag  acctggtgg  ctggcagag  ataagtaca  1080
ccaggttgt  taccttcat  acaacaata  ctctgtagt  ggatcaagt  acttctgcc  1140
acctggaca  aacaccaaa  aggcttctt  ttcgggtgt  agtcttttc  gcaacccgg  1200
ccagtactg  gagatacag  catccacct  cagatgtgt  tacgtgcgc  ctgccattc  1260
actcggaaa  tataagtaa  tctcaagaa  gccctcatt  ttataacct  gcaaaatct  1320
gttaatgtc  ttgctaaaa  ataaataaa  gctagatac  ggaaaccta  ctgcaatgt  1380
gatgtttta  ccacatgac  tattatgca  aaagccaaa  ttccagttt  agtaattgc  1440
tacaataaa  agaaatttt  cctgccatt  tcagaatca  cttttgaag  tttctgttg  1500
tgttaactg  gctactaga  atattctta  ttcactaaa  gtaaaattt  gagtaaata  1560
atatgtcaa  atttagtaa  gcttttctt  tttaatttc  aggaaaaaa  aaaaagagt  1620
tgagtcttc  gtaattcat  gagcagtta  ctcatttga  ataaagtca  atgccaaac  1680
ctagctctg  attaatccc  atcattact  gtaaagcct  atttgaatg  gtgaattca  1740
tacaggcta  g  1751



<210> 9731
<211> 359
<212> PRT
<213> Homo sapiens
<308> P07585
<400> 9731

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
  1               5                  10                  15
Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
             20                  25                  30
Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
         35                  40                  45
Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
     50                  55                  60
Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
 65                  70                  75                  80
Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                 85                  90                  95
Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
             100                105                110
Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
         115                120                125
Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
     130                135                140
Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
 145                150                155                160
Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                 165                170                175
Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
             180                185                190
Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
         195                200                205
Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
     210                215                220
Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
 225                230                235                240
Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                 245                250                255
Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
             260                265                270
Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
         275                280                285
Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
     290                295                300
Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
 305                310                315                320
Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
                 325                330                335
Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
             340                345                350
Ile Gln Leu Gly Asn Tyr Lys 
         355



<210> 9732
<211> 1547
<212> DNA
<213> Rattus norvegicus
<308> X59859
<400> 9732

gcacaagtt  cctgggctg  accatttga  cagagagga  tatttgact  catgctaga  60
gatgaggcc  ctggcataa  cccttacga  cctgacaat  ccctgatat  tatgtgccc  120
taccgatgc  aatgccatc  ccgagtggt  cagtgttct  atctgggtc  ggacaaagt  180
ccctgggaa  ttccacctg  cacaacatt  ctagacctg  aaaacaaca  aataacaga  240
atcaaagag  gggccttta  gaacctgaa  gacttgcat  ccttgatcc  tgtcaacaa  300
aagatcagc  agatcagcc  agaggcatt  aaacctcta  tgaagttgg  aaggcttta  360
ctgtctaag  accacctaa  ggagctgcc  gaaaaattg  ccaaaacac  ccaggagct  420
cgactccac  acaatgaga  caccaaact  aagaaatct  tgttcaatg  actgaaccg  480
atgattgtc  tagaactgg  cggcaaccc  ctgaaaaac  ctgggattg  aaatggagc  540
ttgcaggga  tgaagggtc  cggatacat  cgcatctca  acaccaaca  aactgctat  600
cctcaaggt  tgcccactt  tatcagtga  ctgcatctg  atggcaaca  gatagccaa  660
gttgatgca  ccagcctga  aggaatgtc  aatttgtct  agctgggtt  gagcttcaa  720
agcatcacc  ttgtggaaa  tggcagtct  gctaatgtt  ctcatctga  ggagctcca  780
ttggacaac  acaaactcc  cagagtgcc  gctgggctg  cacagcata  atatgtcca  840
gtcgtctac  ttcataaca  caacatctc  gaagttggg  agcatgact  ctgcctccc  900
tcataccag  ctaggaaga  ttcctacac  gccgtgagt  tttatagca  ccctgtccg  960
tattggcaa  ttcacccac  caccttcag  tgtgtcttc  ggcgctcta  cattcaact  1020
gggaactac  agtaactcc  aaacagcct  atttttata  tcgggaaca  aaaaaccaa  1080
ctgtcaata  tattgctaa  aagaaaaaa  tattttgaa  aagaaagaa  gctagattc  1140
ggaaattca  gtatagcgc  gatgccttt  ccgtatgac  tatcatgca  caagccaaa  1200
atacagatt  aataattac  tacaataaa  atattttat  tgtagtatt  agaatcact  1260
ttaaaattt  ctgtagatg  gaactgagg  atcgaagtc  gatgtaatc  tagatgtca  1320
catttaata  agctaaaag  aacagaata  aaagtcttc  gtaattcat  gagctaaat  1380
gactctttt  acataaagt  aaatgtaga  ctctagcaa  gtattaatc  cctttatta  1440
tggtaaagt  ttatttgaa  atctaagtt  aacatgggc  atgtaaaat  ttcactgtc  1500
tactgaaaa  caataaaat  taaaaaatg  attcaaaaa  aaaaaaa  1547



<210> 9733
<211> 354
<212> PRT
<213> Rattus norvegicus
<308> Q01129
<400> 9733

Met Lys Ala Thr Leu Val Leu Phe Leu Leu Ala Gln Val Ser Trp Ala 
  1               5                  10                  15
Gly Pro Phe Glu Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
             20                  25                  30
Ala Ser Gly Ile Ile Pro Tyr Asp Pro Asp Asn Pro Leu Ile Ser Met 
         35                  40                  45
Cys Pro Tyr Arg Cys Gln Cys His Leu Arg Val Val Gln Cys Ser Asp 
     50                  55                  60
Leu Gly Leu Asp Lys Val Pro Trp Glu Phe Pro Pro Asp Thr Thr Leu 
 65                  70                  75                  80
Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile Lys Glu Gly Ala Phe 
                 85                  90                  95
Lys Asn Leu Lys Asp Leu His Thr Leu Ile Leu Val Asn Asn Lys Ile 
             100                105                110
Ser Lys Ile Ser Pro Glu Ala Phe Lys Pro Leu Val Lys Leu Glu Arg 
         115                120                125
Leu Tyr Leu Ser Lys Asn His Leu Lys Glu Leu Pro Glu Lys Leu Pro 
     130                135                140
Lys Thr Leu Gln Glu Leu Arg Leu His Asp Asn Glu Ile Thr Lys Leu 
 145                150                155                160
Lys Lys Ser Val Phe Asn Gly Leu Asn Arg Met Ile Val Ile Glu Leu 
                 165                170                175
Gly Gly Asn Pro Leu Lys Asn Ser Gly Ile Glu Asn Gly Ala Leu Gln 
             180                185                190
Gly Met Lys Gly Leu Gly Tyr Ile Arg Ile Ser Asp Thr Asn Ile Thr 
         195                200                205
Ala Ile Pro Gln Gly Leu Pro Thr Ser Ile Ser Glu Leu His Leu Asp 
     210                215                220
Gly Asn Lys Ile Ala Lys Val Asp Ala Ala Ser Leu Lys Gly Met Ser 
 225                230                235                240
Asn Leu Ser Lys Leu Gly Leu Ser Phe Asn Ser Ile Thr Val Val Glu 
                 245                250                255
Asn Gly Ser Leu Ala Asn Val Pro His Leu Arg Glu Leu His Leu Asp 
             260                265                270
Asn Asn Lys Leu Leu Arg Val Pro Ala Gly Leu Ala Gln His Lys Tyr 
         275                280                285
Val Gln Val Val Tyr Leu His Asn Asn Asn Ile Ser Glu Val Gly Gln 
     290                295                300
His Asp Phe Cys Leu Pro Ser Tyr Gln Thr Arg Lys Thr Ser Tyr Thr 
 305                310                315                320
Ala Val Ser Leu Tyr Ser Asn Pro Val Arg Tyr Trp Gln Ile His Pro 
                 325                330                335
His Thr Phe Arg Cys Val Phe Gly Arg Ser Thr Ile Gln Leu Gly Asn 
             340                345                350
Tyr Lys 
         355



<210> 9734
<211> 1751
<212> DNA
<213> Homo sapiens
<308> NM_001920
<400> 9734

tttaactgt  ctatggagt  gaagcagga  gttttcaac  tagtcacag  gcagcacct  60
ccccctcct  ctttccaca  ctgcaaact  ttttacttg  gctgaatat  tagtgtaat  120
acatctcag  tttgagggc  cctgtggca  attcccgga  taaaaggtt  cctggttgt  180
aaaatacat  agataaatc  tgaaggcca  tatcatcct  cttctgctt  cacaagttt  240
ctgggctgg  ccgtttcaa  agagaggct  atttgactt  atgctagaa  atgaggctt  300
tgggatagg  ccagaagtt  ctgatgacc  cgacttcga  ccctcccta  gcccagtgt  360
ccccttccg  tgtcaatgc  atcttcgag  ggtccagtg  tctgatttg  gtctggaca  420
agtgccaaa  gatcttccc  ctgacacaa  tctgctaga  ctgcaaaac  acaaaataa  480
cgaaatcaa  gatggagac  ttaagaacc  gaagaacct  cacgcattg  ttcttgtca  540
caataaaat  agcaaagtt  gtcctggag  atttacacc  ttggtgaag  tggaacgac  600
ttatctgtc  aagaatcag  tgaaggaat  gccagaaaa  atgcccaaa  ctcttcagg  660
gctgcgtgc  catgagaat  agatcacca  agtgcgaaa  gttactttc  atggactga  720
ccagatgat  gtcatagaa  tgggcacca  tccgctgaa  agctcagga  ttgaaaatg  780
ggctttcca  ggaatgaag  agctctcct  catccgcat  gctgatacc  atatcacca  840
cattcctca  ggtcttcct  cttccctta  ggaattaca  cttgatggc  acaaaatca  900
cagagttga  gcagctagc  tgaaaggac  gaataattt  gctaagttg  gattgagtt  960
caacagcat  tctgctgtt  acaatggct  tctggccaa  acgcctcat  tgagggagc  1020
tcacttgga  aacaacaag  ttaccagag  acctggtgg  ctggcagag  ataagtaca  1080
ccaggttgt  taccttcat  acaacaata  ctctgtagt  ggatcaagt  acttctgcc  1140
acctggaca  aacaccaaa  aggcttctt  ttcgggtgt  agtcttttc  gcaacccgg  1200
ccagtactg  gagatacag  catccacct  cagatgtgt  tacgtgcgc  ctgccattc  1260
actcggaaa  tataagtaa  tctcaagaa  gccctcatt  ttataacct  gcaaaatct  1320
gttaatgtc  ttgctaaaa  ataaataaa  gctagatac  ggaaaccta  ctgcaatgt  1380
gatgtttta  ccacatgac  tattatgca  aaagccaaa  ttccagttt  agtaattgc  1440
tacaataaa  agaaatttt  cctgccatt  tcagaatca  cttttgaag  tttctgttg  1500
tgttaactg  gctactaga  atattctta  ttcactaaa  gtaaaattt  gagtaaata  1560
atatgtcaa  atttagtaa  gcttttctt  tttaatttc  aggaaaaaa  aaaaagagt  1620
tgagtcttc  gtaattcat  gagcagtta  ctcatttga  ataaagtca  atgccaaac  1680
ctagctctg  attaatccc  atcattact  gtaaagcct  atttgaatg  gtgaattca  1740
tacaggcta  g  1751



<210> 9735
<211> 359
<212> PRT
<213> Homo sapiens
<308> P07585
<400> 9735

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
  1               5                  10                  15
Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
             20                  25                  30
Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
         35                  40                  45
Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
     50                  55                  60
Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
 65                  70                  75                  80
Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                 85                  90                  95
Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
             100                105                110
Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
         115                120                125
Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
     130                135                140
Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
 145                150                155                160
Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                 165                170                175
Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
             180                185                190
Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
         195                200                205
Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
     210                215                220
Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
 225                230                235                240
Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                 245                250                255
Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
             260                265                270
Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
         275                280                285
Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
     290                295                300
Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
 305                310                315                320
Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
                 325                330                335
Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
             340                345                350
Ile Gln Leu Gly Asn Tyr Lys 
         355



<210> 9736
<211> 1547
<212> DNA
<213> Rattus norvegicus
<308> X59859
<400> 9736

gcacaagtt  cctgggctg  accatttga  cagagagga  tatttgact  catgctaga  60
gatgaggcc  ctggcataa  cccttacga  cctgacaat  ccctgatat  tatgtgccc  120
taccgatgc  aatgccatc  ccgagtggt  cagtgttct  atctgggtc  ggacaaagt  180
ccctgggaa  ttccacctg  cacaacatt  ctagacctg  aaaacaaca  aataacaga  240
atcaaagag  gggccttta  gaacctgaa  gacttgcat  ccttgatcc  tgtcaacaa  300
aagatcagc  agatcagcc  agaggcatt  aaacctcta  tgaagttgg  aaggcttta  360
ctgtctaag  accacctaa  ggagctgcc  gaaaaattg  ccaaaacac  ccaggagct  420
cgactccac  acaatgaga  caccaaact  aagaaatct  tgttcaatg  actgaaccg  480
atgattgtc  tagaactgg  cggcaaccc  ctgaaaaac  ctgggattg  aaatggagc  540
ttgcaggga  tgaagggtc  cggatacat  cgcatctca  acaccaaca  aactgctat  600
cctcaaggt  tgcccactt  tatcagtga  ctgcatctg  atggcaaca  gatagccaa  660
gttgatgca  ccagcctga  aggaatgtc  aatttgtct  agctgggtt  gagcttcaa  720
agcatcacc  ttgtggaaa  tggcagtct  gctaatgtt  ctcatctga  ggagctcca  780
ttggacaac  acaaactcc  cagagtgcc  gctgggctg  cacagcata  atatgtcca  840
gtcgtctac  ttcataaca  caacatctc  gaagttggg  agcatgact  ctgcctccc  900
tcataccag  ctaggaaga  ttcctacac  gccgtgagt  tttatagca  ccctgtccg  960
tattggcaa  ttcacccac  caccttcag  tgtgtcttc  ggcgctcta  cattcaact  1020
gggaactac  agtaactcc  aaacagcct  atttttata  tcgggaaca  aaaaaccaa  1080
ctgtcaata  tattgctaa  aagaaaaaa  tattttgaa  aagaaagaa  gctagattc  1140
ggaaattca  gtatagcgc  gatgccttt  ccgtatgac  tatcatgca  caagccaaa  1200
atacagatt  aataattac  tacaataaa  atattttat  tgtagtatt  agaatcact  1260
ttaaaattt  ctgtagatg  gaactgagg  atcgaagtc  gatgtaatc  tagatgtca  1320
catttaata  agctaaaag  aacagaata  aaagtcttc  gtaattcat  gagctaaat  1380
gactctttt  acataaagt  aaatgtaga  ctctagcaa  gtattaatc  cctttatta  1440
tggtaaagt  ttatttgaa  atctaagtt  aacatgggc  atgtaaaat  ttcactgtc  1500
tactgaaaa  caataaaat  taaaaaatg  attcaaaaa  aaaaaaa  1547



<210> 9737
<211> 354
<212> PRT
<213> Rattus norvegicus
<308> Q01129
<400> 9737

Met Lys Ala Thr Leu Val Leu Phe Leu Leu Ala Gln Val Ser Trp Ala 
  1               5                  10                  15
Gly Pro Phe Glu Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
             20                  25                  30
Ala Ser Gly Ile Ile Pro Tyr Asp Pro Asp Asn Pro Leu Ile Ser Met 
         35                  40                  45
Cys Pro Tyr Arg Cys Gln Cys His Leu Arg Val Val Gln Cys Ser Asp 
     50                  55                  60
Leu Gly Leu Asp Lys Val Pro Trp Glu Phe Pro Pro Asp Thr Thr Leu 
 65                  70                  75                  80
Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile Lys Glu Gly Ala Phe 
                 85                  90                  95
Lys Asn Leu Lys Asp Leu His Thr Leu Ile Leu Val Asn Asn Lys Ile 
             100                105                110
Ser Lys Ile Ser Pro Glu Ala Phe Lys Pro Leu Val Lys Leu Glu Arg 
         115                120                125
Leu Tyr Leu Ser Lys Asn His Leu Lys Glu Leu Pro Glu Lys Leu Pro 
     130                135                140
Lys Thr Leu Gln Glu Leu Arg Leu His Asp Asn Glu Ile Thr Lys Leu 
 145                150                155                160
Lys Lys Ser Val Phe Asn Gly Leu Asn Arg Met Ile Val Ile Glu Leu 
                 165                170                175
Gly Gly Asn Pro Leu Lys Asn Ser Gly Ile Glu Asn Gly Ala Leu Gln 
             180                185                190
Gly Met Lys Gly Leu Gly Tyr Ile Arg Ile Ser Asp Thr Asn Ile Thr 
         195                200                205
Ala Ile Pro Gln Gly Leu Pro Thr Ser Ile Ser Glu Leu His Leu Asp 
     210                215                220
Gly Asn Lys Ile Ala Lys Val Asp Ala Ala Ser Leu Lys Gly Met Ser 
 225                230                235                240
Asn Leu Ser Lys Leu Gly Leu Ser Phe Asn Ser Ile Thr Val Val Glu 
                 245                250                255
Asn Gly Ser Leu Ala Asn Val Pro His Leu Arg Glu Leu His Leu Asp 
             260                265                270
Asn Asn Lys Leu Leu Arg Val Pro Ala Gly Leu Ala Gln His Lys Tyr 
         275                280                285
Val Gln Val Val Tyr Leu His Asn Asn Asn Ile Ser Glu Val Gly Gln 
     290                295                300
His Asp Phe Cys Leu Pro Ser Tyr Gln Thr Arg Lys Thr Ser Tyr Thr 
 305                310                315                320
Ala Val Ser Leu Tyr Ser Asn Pro Val Arg Tyr Trp Gln Ile His Pro 
                 325                330                335
His Thr Phe Arg Cys Val Phe Gly Arg Ser Thr Ile Gln Leu Gly Asn 
             340                345                350
Tyr Lys 
         355



<210> 9738
<211> 1751
<212> DNA
<213> Homo sapiens
<308> NM_001920
<400> 9738

tttaactgt  ctatggagt  gaagcagga  gttttcaac  tagtcacag  gcagcacct  60
ccccctcct  ctttccaca  ctgcaaact  ttttacttg  gctgaatat  tagtgtaat  120
acatctcag  tttgagggc  cctgtggca  attcccgga  taaaaggtt  cctggttgt  180
aaaatacat  agataaatc  tgaaggcca  tatcatcct  cttctgctt  cacaagttt  240
ctgggctgg  ccgtttcaa  agagaggct  atttgactt  atgctagaa  atgaggctt  300
tgggatagg  ccagaagtt  ctgatgacc  cgacttcga  ccctcccta  gcccagtgt  360
ccccttccg  tgtcaatgc  atcttcgag  ggtccagtg  tctgatttg  gtctggaca  420
agtgccaaa  gatcttccc  ctgacacaa  tctgctaga  ctgcaaaac  acaaaataa  480
cgaaatcaa  gatggagac  ttaagaacc  gaagaacct  cacgcattg  ttcttgtca  540
caataaaat  agcaaagtt  gtcctggag  atttacacc  ttggtgaag  tggaacgac  600
ttatctgtc  aagaatcag  tgaaggaat  gccagaaaa  atgcccaaa  ctcttcagg  660
gctgcgtgc  catgagaat  agatcacca  agtgcgaaa  gttactttc  atggactga  720
ccagatgat  gtcatagaa  tgggcacca  tccgctgaa  agctcagga  ttgaaaatg  780
ggctttcca  ggaatgaag  agctctcct  catccgcat  gctgatacc  atatcacca  840
cattcctca  ggtcttcct  cttccctta  ggaattaca  cttgatggc  acaaaatca  900
cagagttga  gcagctagc  tgaaaggac  gaataattt  gctaagttg  gattgagtt  960
caacagcat  tctgctgtt  acaatggct  tctggccaa  acgcctcat  tgagggagc  1020
tcacttgga  aacaacaag  ttaccagag  acctggtgg  ctggcagag  ataagtaca  1080
ccaggttgt  taccttcat  acaacaata  ctctgtagt  ggatcaagt  acttctgcc  1140
acctggaca  aacaccaaa  aggcttctt  ttcgggtgt  agtcttttc  gcaacccgg  1200
ccagtactg  gagatacag  catccacct  cagatgtgt  tacgtgcgc  ctgccattc  1260
actcggaaa  tataagtaa  tctcaagaa  gccctcatt  ttataacct  gcaaaatct  1320
gttaatgtc  ttgctaaaa  ataaataaa  gctagatac  ggaaaccta  ctgcaatgt  1380
gatgtttta  ccacatgac  tattatgca  aaagccaaa  ttccagttt  agtaattgc  1440
tacaataaa  agaaatttt  cctgccatt  tcagaatca  cttttgaag  tttctgttg  1500
tgttaactg  gctactaga  atattctta  ttcactaaa  gtaaaattt  gagtaaata  1560
atatgtcaa  atttagtaa  gcttttctt  tttaatttc  aggaaaaaa  aaaaagagt  1620
tgagtcttc  gtaattcat  gagcagtta  ctcatttga  ataaagtca  atgccaaac  1680
ctagctctg  attaatccc  atcattact  gtaaagcct  atttgaatg  gtgaattca  1740
tacaggcta  g  1751



<210> 9739
<211> 359
<212> PRT
<213> Homo sapiens
<308> P07585
<400> 9739

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
  1               5                  10                  15
Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
             20                  25                  30
Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
         35                  40                  45
Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
     50                  55                  60
Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
 65                  70                  75                  80
Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                 85                  90                  95
Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
             100                105                110
Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
         115                120                125
Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
     130                135                140
Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
 145                150                155                160
Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                 165                170                175
Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
             180                185                190
Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
         195                200                205
Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
     210                215                220
Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
 225                230                235                240
Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                 245                250                255
Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
             260                265                270
Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
         275                280                285
Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
     290                295                300
Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
 305                310                315                320
Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
                 325                330                335
Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
             340                345                350
Ile Gln Leu Gly Asn Tyr Lys 
         355



<210> 9740
<211> 3996
<212> DNA
<213> Rattus norvegicus
<308> X59864
<400> 9740

aacggatca  ggccagact  tgaggtaac  aataaaact  accgcagag  gtactgatg  60
atgtgatgg  cagaaaagt  acagtgagg  gcacccaaa  tagccacct  gttgaaacc  120
ctgtggcca  acaaggtca  tcaagcaga  tgggacaaa  gctgagggt  gaccactga  180
aagctgttg  tactgcctg  gacagtatg  gacccctgc  cccaaattc  tgttggggt  240
attacacaa  ctgagtagt  ggcagcttc  atgtggcag  gtgctggcc  ctgttccat  300
aaggactcc  gtaggctag  ctacggggc  atatgttct  tcgacctca  gggagatat  360
tttgggaca  cgccaggcc  tgtctaagg  attccaaag  gggagttgt  gtgaggctg  420
ctttggaga  tttcaggac  agtgcgggt  cggggtgag  cgaacgtgc  ctggaaaga  480
ccagggtgg  ggtggctgc  ggggctggc  ggtccttgt  ctgttggtt  acagagtag  540
ggcgggaat  cgggcggcc  acgtccagt  agaaaaagc  cgggctaga  ggcccgaag  600
accgggtgt  ggagggggg  ggggggtgg  ggtgggggg  aatggggaa  cnggggaag  660
tgggagtgc  ggaggagag  tgtggggtc  gaggagcac  tcgcatctg  agtctggca  720
gagtgttga  ggactgagg  gctagctcg  gcagggcaa  ggcagcagg  cctgggagg  780
aggagcatg  tgtggttcc  aggcattgc  gaggctgga  aacatcggt  tggggttga  840
gggcctgag  tagggttgg  gaggaacgg  gagccagac  ttcatcccg  tcacttttg  900
ttacaggac  tggcggctg  tcggataca  gggagctgc  gggaagggt  cgaccccag  960
cctgggcag  gaaggtgta  ctggcagcg  tgggcaggt  aggaccgcc  tctgctggg  1020
aggtgagtc  ccttcttct  tcttggcct  gctgactga  cttctaaaa  gtttagaga  1080
cgaggccgc  gagaagaag  agctgacct  ccaacagaa  ggcacatag  aaggcagga  1140
agttagcaa  ggagacatc  tctcggggg  agccgagac  gaacaaggc  gggggacca  1200
tgggcaccc  ggagtggaa  gagctttta  agagaagat  gaagaggtg  agggctgcc  1260
gtcaagact  aggctgctg  ctccaggca  gtgatagga  gccttggag  cagtggcag  1320
gactatggg  tccagcaag  gcagaagca  tctaggctg  ggtcaaaca  ggcaagatg  1380
gggtcacag  acacagatg  gtccccagc  gccaccaca  cccacccac  gtaattcat  1440
tagaagcag  ttcaagagt  gctctggca  ggcttctga  gctttgcca  agcttcgat  1500
gccggagaa  gggaaagaa  ggcagtgca  ggtgtcaac  ggaagggaa  gggggctgc  1560
ggtatcgga  tccagaggg  ttttacagc  aggaggctg  agtgggtcc  gcctgcaga  1620
acaccattc  catgaggca  tgcggccca  ggactggtg  ggaaagggc  cacagtgga  1680
ttggtgcac  gtatgccct  accgctcag  ccctgggtc  ggcatgaca  acagaacat  1740
tccagggga  tcaagggca  aggatgaag  cagacaagg  gaggcaggt  gggcagaat  1800
aatgagctt  ctagggagg  aggttgggt  caggtagag  gaggtaaag  agctggggt  1860
gtgagccag  gaggcactg  cctccagag  ccgtggcca  ggagggctt  cgggcggcg  1920
cggagcagt  atcggtgtc  cggagagct  ggactggag  ctagggtaa  tgtctgtcc  1980
actagtggc  acccagttt  ctcccactc  agtccactt  actcatgtc  tcttttctc  2040
ccacagcca  gtctctagc  gaagtggat  tgcctgcca  tcactgaag  cgaggatga  2100
aggtgtggt  aacgtgata  aaagacatg  catggtccg  tgtgatgga  aggacagaa  2160
gacagtcat  cagccttcc  ggtgagcat  ctccctgcc  cagggctag  ccgctcaac  2220
acctaattt  tcacccact  actccagat  ctgtccttt  cagaacacc  tgggctggt  2280
ccgtgggac  ctgccgtag  agccgtctg  tctttcctt  gcccaaaga  ctaacacat  2340
tctgctgct  tctggatcc  cttccccct  ccttgaacc  tcaagatga  aggtgagga  2400
ctcctgccc  acatgggct  ggtggcagg  tgcaagtgc  ggggtctca  tctctccca  2460
ccacagaaa  ggtgctacc  agctcatgt  tgggccttt  aatccgggg  cttctttaa  2520
tccgtctag  tctgaatca  gaatatgct  cactcagaa  cactacact  cctgcctca  2580
gaatcggct  gaaggtgag  cagggcgcc  tttggcagc  cggcaagcc  actccaagc  2640
tactctccc  ccccacatc  cctcaggcc  cctccccct  cccagcccc  ctcatttgt  2700
ttttttctc  ttgcaggta  agctgaagg  acagacggt  acaacatct  gaaagagca  2760
acccacaca  cacccaccc  cccctgaga  tccatcttc  tggccaact  actctgcct  2820
gcccgggag  ccaccaccc  catcatcct  gagccaagc  tctagcccg  gatgacttc  2880
tcatctccc  cctgtcttt  ttcttcttc  tcctttcct  taactctat  tttctttcc  2940
tttgttcct  ctctgcttg  gagactcaa  gcatccgtg  ctctgctcc  ccactcacc  3000
cttttgaat  tgcactaag  cgattgcac  ggtttggag  cccggagat  gcctgagtc  3060
ctccgtatg  atgtataca  cgagtgtgt  ggccccttt  gctatgttg  cccagtgcc  3120
gcccgtcat  cacttctgt  tgagggcaa  tgggtgtgg  cgtgcgctt  aggcctcac  3180
ttccccttg  ctagtctgg  agcagttcc  tcataaagt  ttcaacgca  cttccttca  3240
cctttgtcc  tcctcacca  ggcctcacc  gaggtcctg  gtccaccaa  aaatacagt  3300
acagtcatt  gtctcgtgc  cttgaatat  atgcgactc  cttgggggg  tggggggca  3360
gggaaagaa  tgagggaag  ggaataaaa  ggatggggt  cagcaccca  aatgaaggg  3420
attatgaag  agggggcat  taggatgga  tgaagaata  gagatggga  gggcttatg  3480
aaaggacgg  ggcattggg  tgggaggcc  tgggagggg  ctcatgaga  accaagaag  3540
tacagtatg  aaggggcct  tgaatatga  atggtgcct  aggaatgag  agcgcagta  3600
acatcacag  ggagagtgg  agagtgcca  gaggagaca  aggcaaggc  gtgaggagg  3660
tccctcaag  ctggggagg  gaaggacag  catccttag  aatgagaga  tggtggcct  3720
accagaaac  tggattcta  actgctgcc  gtcctgtct  gatgactcc  cgagtcctc  3780
cacttatcc  aactcctga  gcctactgt  aactgcaaa  tgaacctga  tcccgactc  3840
tcgcagagg  tgctaatga  gtagacagc  atatgtgag  ctgggtaga  cacagccac  3900
taaaggagc  catggtggc  cctgggctt  cctctcctg  tctgagcat  ctcagctct  3960
gactggagc  cacggtaga  gcctgcagt  gtacca  3996



<210> 9741
<211> 158
<212> PRT
<213> Rattus norvegicus
<308> CAA42524
<400> 9741

Met Gly Ser Ser Lys Ser Arg Ser Ile Leu Gly Trp Gly Gln Thr Gly 
  1               5                  10                  15
Gln Asp Gly Gly His Arg Thr Gln Met Gly Pro Gln Pro Pro Pro His 
             20                  25                  30
Pro Thr His Arg Asn Ser Phe Arg Ser Arg Phe Lys Ser Gly Ser Gly 
         35                  40                  45
Arg Ala Ser Glu Ala Leu Pro Glu Leu Arg Trp Pro Glu Asn Gly Lys 
     50                  55                  60
Glu Gly Gln Cys Arg Val Ser Thr Gly Arg Glu Arg Gly Leu Gln Val 
 65                  70                  75                  80
Ser Asp Ser Arg Gly Ile Leu Gln Gln Gly Gly Cys Ser Gly Ser Ser 
                 85                  90                  95
Leu Gln Thr His His Ser His Glu Ala Leu Arg Pro Arg Asp Trp Cys 
             100                105                110
Gly Lys Gly Pro Gln Trp Thr Trp Cys Thr Val Cys Pro Asn Arg Ser 
         115                120                125
Val Pro Gly Ser Gly Met Thr Asp Arg Thr Phe Pro Gly Glu Ser Arg 
     130                135                140
Ala Gln Asp Glu Ala Arg Gln Gly Glu Ala Gly Gly Ala Glu 
 145                150                155



<210> 9742
<211> 3996
<212> DNA
<213> Rattus norvegicus
<308> X59864
<400> 9742

aacggatca  ggccagact  tgaggtaac  aataaaact  accgcagag  gtactgatg  60
atgtgatgg  cagaaaagt  acagtgagg  gcacccaaa  tagccacct  gttgaaacc  120
ctgtggcca  acaaggtca  tcaagcaga  tgggacaaa  gctgagggt  gaccactga  180
aagctgttg  tactgcctg  gacagtatg  gacccctgc  cccaaattc  tgttggggt  240
attacacaa  ctgagtagt  ggcagcttc  atgtggcag  gtgctggcc  ctgttccat  300
aaggactcc  gtaggctag  ctacggggc  atatgttct  tcgacctca  gggagatat  360
tttgggaca  cgccaggcc  tgtctaagg  attccaaag  gggagttgt  gtgaggctg  420
ctttggaga  tttcaggac  agtgcgggt  cggggtgag  cgaacgtgc  ctggaaaga  480
ccagggtgg  ggtggctgc  ggggctggc  ggtccttgt  ctgttggtt  acagagtag  540
ggcgggaat  cgggcggcc  acgtccagt  agaaaaagc  cgggctaga  ggcccgaag  600
accgggtgt  ggagggggg  ggggggtgg  ggtgggggg  aatggggaa  cnggggaag  660
tgggagtgc  ggaggagag  tgtggggtc  gaggagcac  tcgcatctg  agtctggca  720
gagtgttga  ggactgagg  gctagctcg  gcagggcaa  ggcagcagg  cctgggagg  780
aggagcatg  tgtggttcc  aggcattgc  gaggctgga  aacatcggt  tggggttga  840
gggcctgag  tagggttgg  gaggaacgg  gagccagac  ttcatcccg  tcacttttg  900
ttacaggac  tggcggctg  tcggataca  gggagctgc  gggaagggt  cgaccccag  960
cctgggcag  gaaggtgta  ctggcagcg  tgggcaggt  aggaccgcc  tctgctggg  1020
aggtgagtc  ccttcttct  tcttggcct  gctgactga  cttctaaaa  gtttagaga  1080
cgaggccgc  gagaagaag  agctgacct  ccaacagaa  ggcacatag  aaggcagga  1140
agttagcaa  ggagacatc  tctcggggg  agccgagac  gaacaaggc  gggggacca  1200
tgggcaccc  ggagtggaa  gagctttta  agagaagat  gaagaggtg  agggctgcc  1260
gtcaagact  aggctgctg  ctccaggca  gtgatagga  gccttggag  cagtggcag  1320
gactatggg  tccagcaag  gcagaagca  tctaggctg  ggtcaaaca  ggcaagatg  1380
gggtcacag  acacagatg  gtccccagc  gccaccaca  cccacccac  gtaattcat  1440
tagaagcag  ttcaagagt  gctctggca  ggcttctga  gctttgcca  agcttcgat  1500
gccggagaa  gggaaagaa  ggcagtgca  ggtgtcaac  ggaagggaa  gggggctgc  1560
ggtatcgga  tccagaggg  ttttacagc  aggaggctg  agtgggtcc  gcctgcaga  1620
acaccattc  catgaggca  tgcggccca  ggactggtg  ggaaagggc  cacagtgga  1680
ttggtgcac  gtatgccct  accgctcag  ccctgggtc  ggcatgaca  acagaacat  1740
tccagggga  tcaagggca  aggatgaag  cagacaagg  gaggcaggt  gggcagaat  1800
aatgagctt  ctagggagg  aggttgggt  caggtagag  gaggtaaag  agctggggt  1860
gtgagccag  gaggcactg  cctccagag  ccgtggcca  ggagggctt  cgggcggcg  1920
cggagcagt  atcggtgtc  cggagagct  ggactggag  ctagggtaa  tgtctgtcc  1980
actagtggc  acccagttt  ctcccactc  agtccactt  actcatgtc  tcttttctc  2040
ccacagcca  gtctctagc  gaagtggat  tgcctgcca  tcactgaag  cgaggatga  2100
aggtgtggt  aacgtgata  aaagacatg  catggtccg  tgtgatgga  aggacagaa  2160
gacagtcat  cagccttcc  ggtgagcat  ctccctgcc  cagggctag  ccgctcaac  2220
acctaattt  tcacccact  actccagat  ctgtccttt  cagaacacc  tgggctggt  2280
ccgtgggac  ctgccgtag  agccgtctg  tctttcctt  gcccaaaga  ctaacacat  2340
tctgctgct  tctggatcc  cttccccct  ccttgaacc  tcaagatga  aggtgagga  2400
ctcctgccc  acatgggct  ggtggcagg  tgcaagtgc  ggggtctca  tctctccca  2460
ccacagaaa  ggtgctacc  agctcatgt  tgggccttt  aatccgggg  cttctttaa  2520
tccgtctag  tctgaatca  gaatatgct  cactcagaa  cactacact  cctgcctca  2580
gaatcggct  gaaggtgag  cagggcgcc  tttggcagc  cggcaagcc  actccaagc  2640
tactctccc  ccccacatc  cctcaggcc  cctccccct  cccagcccc  ctcatttgt  2700
ttttttctc  ttgcaggta  agctgaagg  acagacggt  acaacatct  gaaagagca  2760
acccacaca  cacccaccc  cccctgaga  tccatcttc  tggccaact  actctgcct  2820
gcccgggag  ccaccaccc  catcatcct  gagccaagc  tctagcccg  gatgacttc  2880
tcatctccc  cctgtcttt  ttcttcttc  tcctttcct  taactctat  tttctttcc  2940
tttgttcct  ctctgcttg  gagactcaa  gcatccgtg  ctctgctcc  ccactcacc  3000
cttttgaat  tgcactaag  cgattgcac  ggtttggag  cccggagat  gcctgagtc  3060
ctccgtatg  atgtataca  cgagtgtgt  ggccccttt  gctatgttg  cccagtgcc  3120
gcccgtcat  cacttctgt  tgagggcaa  tgggtgtgg  cgtgcgctt  aggcctcac  3180
ttccccttg  ctagtctgg  agcagttcc  tcataaagt  ttcaacgca  cttccttca  3240
cctttgtcc  tcctcacca  ggcctcacc  gaggtcctg  gtccaccaa  aaatacagt  3300
acagtcatt  gtctcgtgc  cttgaatat  atgcgactc  cttgggggg  tggggggca  3360
gggaaagaa  tgagggaag  ggaataaaa  ggatggggt  cagcaccca  aatgaaggg  3420
attatgaag  agggggcat  taggatgga  tgaagaata  gagatggga  gggcttatg  3480
aaaggacgg  ggcattggg  tgggaggcc  tgggagggg  ctcatgaga  accaagaag  3540
tacagtatg  aaggggcct  tgaatatga  atggtgcct  aggaatgag  agcgcagta  3600
acatcacag  ggagagtgg  agagtgcca  gaggagaca  aggcaaggc  gtgaggagg  3660
tccctcaag  ctggggagg  gaaggacag  catccttag  aatgagaga  tggtggcct  3720
accagaaac  tggattcta  actgctgcc  gtcctgtct  gatgactcc  cgagtcctc  3780
cacttatcc  aactcctga  gcctactgt  aactgcaaa  tgaacctga  tcccgactc  3840
tcgcagagg  tgctaatga  gtagacagc  atatgtgag  ctgggtaga  cacagccac  3900
taaaggagc  catggtggc  cctgggctt  cctctcctg  tctgagcat  ctcagctct  3960
gactggagc  cacggtaga  gcctgcagt  gtacca  3996



<210> 9743
<211> 158
<212> PRT
<213> Rattus norvegicus
<308> CAA42524
<400> 9743

Met Gly Ser Ser Lys Ser Arg Ser Ile Leu Gly Trp Gly Gln Thr Gly 
  1               5                  10                  15
Gln Asp Gly Gly His Arg Thr Gln Met Gly Pro Gln Pro Pro Pro His 
             20                  25                  30
Pro Thr His Arg Asn Ser Phe Arg Ser Arg Phe Lys Ser Gly Ser Gly 
         35                  40                  45
Arg Ala Ser Glu Ala Leu Pro Glu Leu Arg Trp Pro Glu Asn Gly Lys 
     50                  55                  60
Glu Gly Gln Cys Arg Val Ser Thr Gly Arg Glu Arg Gly Leu Gln Val 
 65                  70                  75                  80
Ser Asp Ser Arg Gly Ile Leu Gln Gln Gly Gly Cys Ser Gly Ser Ser 
                 85                  90                  95
Leu Gln Thr His His Ser His Glu Ala Leu Arg Pro Arg Asp Trp Cys 
             100                105                110
Gly Lys Gly Pro Gln Trp Thr Trp Cys Thr Val Cys Pro Asn Arg Ser 
         115                120                125
Val Pro Gly Ser Gly Met Thr Asp Arg Thr Phe Pro Gly Glu Ser Arg 
     130                135                140
Ala Gln Asp Glu Ala Arg Gln Gly Glu Ala Gly Gly Ala Glu 
 145                150                155



<210> 9744
<211> 3996
<212> DNA
<213> Rattus norvegicus
<308> X59864
<400> 9744

aacggatca  ggccagact  tgaggtaac  aataaaact  accgcagag  gtactgatg  60
atgtgatgg  cagaaaagt  acagtgagg  gcacccaaa  tagccacct  gttgaaacc  120
ctgtggcca  acaaggtca  tcaagcaga  tgggacaaa  gctgagggt  gaccactga  180
aagctgttg  tactgcctg  gacagtatg  gacccctgc  cccaaattc  tgttggggt  240
attacacaa  ctgagtagt  ggcagcttc  atgtggcag  gtgctggcc  ctgttccat  300
aaggactcc  gtaggctag  ctacggggc  atatgttct  tcgacctca  gggagatat  360
tttgggaca  cgccaggcc  tgtctaagg  attccaaag  gggagttgt  gtgaggctg  420
ctttggaga  tttcaggac  agtgcgggt  cggggtgag  cgaacgtgc  ctggaaaga  480
ccagggtgg  ggtggctgc  ggggctggc  ggtccttgt  ctgttggtt  acagagtag  540
ggcgggaat  cgggcggcc  acgtccagt  agaaaaagc  cgggctaga  ggcccgaag  600
accgggtgt  ggagggggg  ggggggtgg  ggtgggggg  aatggggaa  cnggggaag  660
tgggagtgc  ggaggagag  tgtggggtc  gaggagcac  tcgcatctg  agtctggca  720
gagtgttga  ggactgagg  gctagctcg  gcagggcaa  ggcagcagg  cctgggagg  780
aggagcatg  tgtggttcc  aggcattgc  gaggctgga  aacatcggt  tggggttga  840
gggcctgag  tagggttgg  gaggaacgg  gagccagac  ttcatcccg  tcacttttg  900
ttacaggac  tggcggctg  tcggataca  gggagctgc  gggaagggt  cgaccccag  960
cctgggcag  gaaggtgta  ctggcagcg  tgggcaggt  aggaccgcc  tctgctggg  1020
aggtgagtc  ccttcttct  tcttggcct  gctgactga  cttctaaaa  gtttagaga  1080
cgaggccgc  gagaagaag  agctgacct  ccaacagaa  ggcacatag  aaggcagga  1140
agttagcaa  ggagacatc  tctcggggg  agccgagac  gaacaaggc  gggggacca  1200
tgggcaccc  ggagtggaa  gagctttta  agagaagat  gaagaggtg  agggctgcc  1260
gtcaagact  aggctgctg  ctccaggca  gtgatagga  gccttggag  cagtggcag  1320
gactatggg  tccagcaag  gcagaagca  tctaggctg  ggtcaaaca  ggcaagatg  1380
gggtcacag  acacagatg  gtccccagc  gccaccaca  cccacccac  gtaattcat  1440
tagaagcag  ttcaagagt  gctctggca  ggcttctga  gctttgcca  agcttcgat  1500
gccggagaa  gggaaagaa  ggcagtgca  ggtgtcaac  ggaagggaa  gggggctgc  1560
ggtatcgga  tccagaggg  ttttacagc  aggaggctg  agtgggtcc  gcctgcaga  1620
acaccattc  catgaggca  tgcggccca  ggactggtg  ggaaagggc  cacagtgga  1680
ttggtgcac  gtatgccct  accgctcag  ccctgggtc  ggcatgaca  acagaacat  1740
tccagggga  tcaagggca  aggatgaag  cagacaagg  gaggcaggt  gggcagaat  1800
aatgagctt  ctagggagg  aggttgggt  caggtagag  gaggtaaag  agctggggt  1860
gtgagccag  gaggcactg  cctccagag  ccgtggcca  ggagggctt  cgggcggcg  1920
cggagcagt  atcggtgtc  cggagagct  ggactggag  ctagggtaa  tgtctgtcc  1980
actagtggc  acccagttt  ctcccactc  agtccactt  actcatgtc  tcttttctc  2040
ccacagcca  gtctctagc  gaagtggat  tgcctgcca  tcactgaag  cgaggatga  2100
aggtgtggt  aacgtgata  aaagacatg  catggtccg  tgtgatgga  aggacagaa  2160
gacagtcat  cagccttcc  ggtgagcat  ctccctgcc  cagggctag  ccgctcaac  2220
acctaattt  tcacccact  actccagat  ctgtccttt  cagaacacc  tgggctggt  2280
ccgtgggac  ctgccgtag  agccgtctg  tctttcctt  gcccaaaga  ctaacacat  2340
tctgctgct  tctggatcc  cttccccct  ccttgaacc  tcaagatga  aggtgagga  2400
ctcctgccc  acatgggct  ggtggcagg  tgcaagtgc  ggggtctca  tctctccca  2460
ccacagaaa  ggtgctacc  agctcatgt  tgggccttt  aatccgggg  cttctttaa  2520
tccgtctag  tctgaatca  gaatatgct  cactcagaa  cactacact  cctgcctca  2580
gaatcggct  gaaggtgag  cagggcgcc  tttggcagc  cggcaagcc  actccaagc  2640
tactctccc  ccccacatc  cctcaggcc  cctccccct  cccagcccc  ctcatttgt  2700
ttttttctc  ttgcaggta  agctgaagg  acagacggt  acaacatct  gaaagagca  2760
acccacaca  cacccaccc  cccctgaga  tccatcttc  tggccaact  actctgcct  2820
gcccgggag  ccaccaccc  catcatcct  gagccaagc  tctagcccg  gatgacttc  2880
tcatctccc  cctgtcttt  ttcttcttc  tcctttcct  taactctat  tttctttcc  2940
tttgttcct  ctctgcttg  gagactcaa  gcatccgtg  ctctgctcc  ccactcacc  3000
cttttgaat  tgcactaag  cgattgcac  ggtttggag  cccggagat  gcctgagtc  3060
ctccgtatg  atgtataca  cgagtgtgt  ggccccttt  gctatgttg  cccagtgcc  3120
gcccgtcat  cacttctgt  tgagggcaa  tgggtgtgg  cgtgcgctt  aggcctcac  3180
ttccccttg  ctagtctgg  agcagttcc  tcataaagt  ttcaacgca  cttccttca  3240
cctttgtcc  tcctcacca  ggcctcacc  gaggtcctg  gtccaccaa  aaatacagt  3300
acagtcatt  gtctcgtgc  cttgaatat  atgcgactc  cttgggggg  tggggggca  3360
gggaaagaa  tgagggaag  ggaataaaa  ggatggggt  cagcaccca  aatgaaggg  3420
attatgaag  agggggcat  taggatgga  tgaagaata  gagatggga  gggcttatg  3480
aaaggacgg  ggcattggg  tgggaggcc  tgggagggg  ctcatgaga  accaagaag  3540
tacagtatg  aaggggcct  tgaatatga  atggtgcct  aggaatgag  agcgcagta  3600
acatcacag  ggagagtgg  agagtgcca  gaggagaca  aggcaaggc  gtgaggagg  3660
tccctcaag  ctggggagg  gaaggacag  catccttag  aatgagaga  tggtggcct  3720
accagaaac  tggattcta  actgctgcc  gtcctgtct  gatgactcc  cgagtcctc  3780
cacttatcc  aactcctga  gcctactgt  aactgcaaa  tgaacctga  tcccgactc  3840
tcgcagagg  tgctaatga  gtagacagc  atatgtgag  ctgggtaga  cacagccac  3900
taaaggagc  catggtggc  cctgggctt  cctctcctg  tctgagcat  ctcagctct  3960
gactggagc  cacggtaga  gcctgcagt  gtacca  3996



<210> 9745
<211> 158
<212> PRT
<213> Rattus norvegicus
<308> CAA42524
<400> 9745

Met Gly Ser Ser Lys Ser Arg Ser Ile Leu Gly Trp Gly Gln Thr Gly 
  1               5                  10                  15
Gln Asp Gly Gly His Arg Thr Gln Met Gly Pro Gln Pro Pro Pro His 
             20                  25                  30
Pro Thr His Arg Asn Ser Phe Arg Ser Arg Phe Lys Ser Gly Ser Gly 
         35                  40                  45
Arg Ala Ser Glu Ala Leu Pro Glu Leu Arg Trp Pro Glu Asn Gly Lys 
     50                  55                  60
Glu Gly Gln Cys Arg Val Ser Thr Gly Arg Glu Arg Gly Leu Gln Val 
 65                  70                  75                  80
Ser Asp Ser Arg Gly Ile Leu Gln Gln Gly Gly Cys Ser Gly Ser Ser 
                 85                  90                  95
Leu Gln Thr His His Ser His Glu Ala Leu Arg Pro Arg Asp Trp Cys 
             100                105                110
Gly Lys Gly Pro Gln Trp Thr Trp Cys Thr Val Cys Pro Asn Arg Ser 
         115                120                125
Val Pro Gly Ser Gly Met Thr Asp Arg Thr Phe Pro Gly Glu Ser Arg 
     130                135                140
Ala Gln Asp Glu Ala Arg Gln Gly Glu Ala Gly Gly Ala Glu 
 145                150                155



<210> 9746
<211> 3996
<212> DNA
<213> Rattus norvegicus
<308> X59864
<400> 9746

aacggatca  ggccagact  tgaggtaac  aataaaact  accgcagag  gtactgatg  60
atgtgatgg  cagaaaagt  acagtgagg  gcacccaaa  tagccacct  gttgaaacc  120
ctgtggcca  acaaggtca  tcaagcaga  tgggacaaa  gctgagggt  gaccactga  180
aagctgttg  tactgcctg  gacagtatg  gacccctgc  cccaaattc  tgttggggt  240
attacacaa  ctgagtagt  ggcagcttc  atgtggcag  gtgctggcc  ctgttccat  300
aaggactcc  gtaggctag  ctacggggc  atatgttct  tcgacctca  gggagatat  360
tttgggaca  cgccaggcc  tgtctaagg  attccaaag  gggagttgt  gtgaggctg  420
ctttggaga  tttcaggac  agtgcgggt  cggggtgag  cgaacgtgc  ctggaaaga  480
ccagggtgg  ggtggctgc  ggggctggc  ggtccttgt  ctgttggtt  acagagtag  540
ggcgggaat  cgggcggcc  acgtccagt  agaaaaagc  cgggctaga  ggcccgaag  600
accgggtgt  ggagggggg  ggggggtgg  ggtgggggg  aatggggaa  cnggggaag  660
tgggagtgc  ggaggagag  tgtggggtc  gaggagcac  tcgcatctg  agtctggca  720
gagtgttga  ggactgagg  gctagctcg  gcagggcaa  ggcagcagg  cctgggagg  780
aggagcatg  tgtggttcc  aggcattgc  gaggctgga  aacatcggt  tggggttga  840
gggcctgag  tagggttgg  gaggaacgg  gagccagac  ttcatcccg  tcacttttg  900
ttacaggac  tggcggctg  tcggataca  gggagctgc  gggaagggt  cgaccccag  960
cctgggcag  gaaggtgta  ctggcagcg  tgggcaggt  aggaccgcc  tctgctggg  1020
aggtgagtc  ccttcttct  tcttggcct  gctgactga  cttctaaaa  gtttagaga  1080
cgaggccgc  gagaagaag  agctgacct  ccaacagaa  ggcacatag  aaggcagga  1140
agttagcaa  ggagacatc  tctcggggg  agccgagac  gaacaaggc  gggggacca  1200
tgggcaccc  ggagtggaa  gagctttta  agagaagat  gaagaggtg  agggctgcc  1260
gtcaagact  aggctgctg  ctccaggca  gtgatagga  gccttggag  cagtggcag  1320
gactatggg  tccagcaag  gcagaagca  tctaggctg  ggtcaaaca  ggcaagatg  1380
gggtcacag  acacagatg  gtccccagc  gccaccaca  cccacccac  gtaattcat  1440
tagaagcag  ttcaagagt  gctctggca  ggcttctga  gctttgcca  agcttcgat  1500
gccggagaa  gggaaagaa  ggcagtgca  ggtgtcaac  ggaagggaa  gggggctgc  1560
ggtatcgga  tccagaggg  ttttacagc  aggaggctg  agtgggtcc  gcctgcaga  1620
acaccattc  catgaggca  tgcggccca  ggactggtg  ggaaagggc  cacagtgga  1680
ttggtgcac  gtatgccct  accgctcag  ccctgggtc  ggcatgaca  acagaacat  1740
tccagggga  tcaagggca  aggatgaag  cagacaagg  gaggcaggt  gggcagaat  1800
aatgagctt  ctagggagg  aggttgggt  caggtagag  gaggtaaag  agctggggt  1860
gtgagccag  gaggcactg  cctccagag  ccgtggcca  ggagggctt  cgggcggcg  1920
cggagcagt  atcggtgtc  cggagagct  ggactggag  ctagggtaa  tgtctgtcc  1980
actagtggc  acccagttt  ctcccactc  agtccactt  actcatgtc  tcttttctc  2040
ccacagcca  gtctctagc  gaagtggat  tgcctgcca  tcactgaag  cgaggatga  2100
aggtgtggt  aacgtgata  aaagacatg  catggtccg  tgtgatgga  aggacagaa  2160
gacagtcat  cagccttcc  ggtgagcat  ctccctgcc  cagggctag  ccgctcaac  2220
acctaattt  tcacccact  actccagat  ctgtccttt  cagaacacc  tgggctggt  2280
ccgtgggac  ctgccgtag  agccgtctg  tctttcctt  gcccaaaga  ctaacacat  2340
tctgctgct  tctggatcc  cttccccct  ccttgaacc  tcaagatga  aggtgagga  2400
ctcctgccc  acatgggct  ggtggcagg  tgcaagtgc  ggggtctca  tctctccca  2460
ccacagaaa  ggtgctacc  agctcatgt  tgggccttt  aatccgggg  cttctttaa  2520
tccgtctag  tctgaatca  gaatatgct  cactcagaa  cactacact  cctgcctca  2580
gaatcggct  gaaggtgag  cagggcgcc  tttggcagc  cggcaagcc  actccaagc  2640
tactctccc  ccccacatc  cctcaggcc  cctccccct  cccagcccc  ctcatttgt  2700
ttttttctc  ttgcaggta  agctgaagg  acagacggt  acaacatct  gaaagagca  2760
acccacaca  cacccaccc  cccctgaga  tccatcttc  tggccaact  actctgcct  2820
gcccgggag  ccaccaccc  catcatcct  gagccaagc  tctagcccg  gatgacttc  2880
tcatctccc  cctgtcttt  ttcttcttc  tcctttcct  taactctat  tttctttcc  2940
tttgttcct  ctctgcttg  gagactcaa  gcatccgtg  ctctgctcc  ccactcacc  3000
cttttgaat  tgcactaag  cgattgcac  ggtttggag  cccggagat  gcctgagtc  3060
ctccgtatg  atgtataca  cgagtgtgt  ggccccttt  gctatgttg  cccagtgcc  3120
gcccgtcat  cacttctgt  tgagggcaa  tgggtgtgg  cgtgcgctt  aggcctcac  3180
ttccccttg  ctagtctgg  agcagttcc  tcataaagt  ttcaacgca  cttccttca  3240
cctttgtcc  tcctcacca  ggcctcacc  gaggtcctg  gtccaccaa  aaatacagt  3300
acagtcatt  gtctcgtgc  cttgaatat  atgcgactc  cttgggggg  tggggggca  3360
gggaaagaa  tgagggaag  ggaataaaa  ggatggggt  cagcaccca  aatgaaggg  3420
attatgaag  agggggcat  taggatgga  tgaagaata  gagatggga  gggcttatg  3480
aaaggacgg  ggcattggg  tgggaggcc  tgggagggg  ctcatgaga  accaagaag  3540
tacagtatg  aaggggcct  tgaatatga  atggtgcct  aggaatgag  agcgcagta  3600
acatcacag  ggagagtgg  agagtgcca  gaggagaca  aggcaaggc  gtgaggagg  3660
tccctcaag  ctggggagg  gaaggacag  catccttag  aatgagaga  tggtggcct  3720
accagaaac  tggattcta  actgctgcc  gtcctgtct  gatgactcc  cgagtcctc  3780
cacttatcc  aactcctga  gcctactgt  aactgcaaa  tgaacctga  tcccgactc  3840
tcgcagagg  tgctaatga  gtagacagc  atatgtgag  ctgggtaga  cacagccac  3900
taaaggagc  catggtggc  cctgggctt  cctctcctg  tctgagcat  ctcagctct  3960
gactggagc  cacggtaga  gcctgcagt  gtacca  3996



<210> 9747
<211> 158
<212> PRT
<213> Rattus norvegicus
<308> CAA42524
<400> 9747

Met Gly Ser Ser Lys Ser Arg Ser Ile Leu Gly Trp Gly Gln Thr Gly 
  1               5                  10                  15
Gln Asp Gly Gly His Arg Thr Gln Met Gly Pro Gln Pro Pro Pro His 
             20                  25                  30
Pro Thr His Arg Asn Ser Phe Arg Ser Arg Phe Lys Ser Gly Ser Gly 
         35                  40                  45
Arg Ala Ser Glu Ala Leu Pro Glu Leu Arg Trp Pro Glu Asn Gly Lys 
     50                  55                  60
Glu Gly Gln Cys Arg Val Ser Thr Gly Arg Glu Arg Gly Leu Gln Val 
 65                  70                  75                  80
Ser Asp Ser Arg Gly Ile Leu Gln Gln Gly Gly Cys Ser Gly Ser Ser 
                 85                  90                  95
Leu Gln Thr His His Ser His Glu Ala Leu Arg Pro Arg Asp Trp Cys 
             100                105                110
Gly Lys Gly Pro Gln Trp Thr Trp Cys Thr Val Cys Pro Asn Arg Ser 
         115                120                125
Val Pro Gly Ser Gly Met Thr Asp Arg Thr Phe Pro Gly Glu Ser Arg 
     130                135                140
Ala Gln Asp Glu Ala Arg Gln Gly Glu Ala Gly Gly Ala Glu 
 145                150                155



<210> 9748
<211> 1635
<212> DNA
<213> Rattus norvegicus
<308> X59961
<400> 9748

agaattcaa  cattaaata  cccacgcag  aacatctgg  gatgggata  tgtgtattc  60
atacgctag  aaatgaata  taaaatagt  ctacacctt  tgagggctt  tttgccagt  120
gttactaag  cagtagtaa  gctctaatt  tgaaatctt  gtggctctg  aaagagcct  180
tggatctgt  gtgagctct  tgggctcac  tggagctgg  gtacttggt  actgccttg  240
tgccctcgg  caccgcgtg  ttggccagc  ccccgggca  cagcaggcg  acggccgtc  300
ggatctccc  ggacgtgat  gtcgagcgc  tgttgtaat  cgccaggcg  cgctctccc  360
cgatgcgct  gaagatgtc  ttcacgaac  agttcatga  gcccatggc  ttggaagag  420
ttccggtat  cgggtgcac  tgcttcagc  ccttgtaca  gtacaccga  tagctctcc  480
tgcggctgc  cttgcgttc  ttgccgtcc  tcttctggg  cttggtcac  gccttcttg  540
agcccttct  cggggcggg  cgggacttg  cgggctcag  cattcgtca  cagagtgtg  600
acaccaaga  agaacagaa  gagttgttg  gagttctcg  gttcttcct  ctatttaaa  660
aaagctgta  ctgttcttg  tcggagatt  ctgagacgt  cattgcacg  actgtccaa  720
caaaatatg  atctttcaa  tccacgata  tattggctt  ggttaaaaa  gctgtatga  780
tagccatta  aatcactcc  tttttcgcg  caggagttg  gtataagtt  agtgctgtg  840
ctgcttcac  ttacacctt  atatttctt  taaagaggt  aaatgtctg  tcgcggcaa  900
cagggaggc  aggctcgcg  caaggccaa  acccgctcc  cccgggccg  cctgcagtt  960
cccgtgggc  gcgtgcacc  tctgttgcg  aagggaaac  actcggagc  cgtgggcgc  1020
ggcgccccg  tgtacctgg  ggccgtact  gagtacctg  cggccgaaa  cctggagct  1080
gcggctaat  cggcgaggg  caacaagaa  acgcggatc  tcccgcgcc  cctgcagct  1140
gccatccgc  acgatgagg  gctcaacaa  ctgctgggc  gcgtgacca  cgcgcaggg  1200
ggcgttctg  ccaacatcc  ggctgtgct  ctgcccaag  agaccgaga  ccaccacaa  1260
cctaaggga  agtaaacca  tgagcgaac  ttttatctt  tgaaagacc  aaggctctt  1320
tcagagcca  cacttgttc  tgtaagagt  ggtaaccaa  ccctggttt  acctacttt  1380
ttgcaagcc  atatcaatc  taaaagcat  aaactaatt  tatttgctg  ttgggctaa  1440
tctttaatc  ttaacaggt  tgtggttcc  gcagagaga  tattgggat  gtagaaaca  1500
gctggtttt  atttttata  tcagctctt  cagtacttt  cctagtatt  tttctcagt  1560
gcagcagac  taacgctgg  attgggaga  gtacatagc  tttacagga  agctggtag  1620
ttacatgca  agcgt  1635



<210> 9749
<211> 124
<212> PRT
<213> Rattus norvegicus
<308> CAA42585
<400> 9749

Pro Glu Pro Ala Lys Ser Arg Pro Ala Pro Lys Lys Gly Ser Lys Lys 
  1               5                  10                  15
Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Lys Glu Arg Lys Arg Ser 
             20                  25                  30
Arg Lys Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln Val 
         35                  40                  45
His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn Ser 
     50                  55                  60
Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Arg Arg Leu Ala 
 65                  70                  75                  80
His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln Thr Ala 
                 85                  90                  95
Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val Ser Glu 
             100                105                110
Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
         115                120



<210> 9750
<211> 425
<212> DNA
<213> Homo sapiens
<308> NM_003524
<400> 9750

atgcctgat  cagctaagt  cgctcccgc  ccgaagaag  gctccaaga  ggcggtgac  60
aaggcgcag  agaaggatg  caagaagcg  aaacgcagc  gcaaggaga  ctactccgt  120
tacgtttac  aggtgctga  gcaagtcca  cccgacacc  gcatctcct  caaagccat  180
gggatcatg  attcctttg  caacgatat  ttcgagcgc  tcgccggcg  ggcttcccg  240
ctggctcat  acaacaagc  ttcgaccat  acctccagg  agatccaga  agccgtgcg  300
ctgctgctg  ctggggaac  ggccaagca  gccgtgtcc  agggcacta  ggccgtcac  360
aagtacacc  gctccaaat  aatggacgc  tgttcaaac  caaaggctc  tttcagagc  420
actta  425



<210> 9751
<211> 126
<212> PRT
<213> Homo sapiens
<308> NP_003515
<400> 9751

Met Pro Asp Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys 
  1               5                  10                  15
Lys Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg 
             20                  25                  30
Ser Arg Lys Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln 
         35                  40                  45
Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn 
     50                  55                  60
Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg 
 65                  70                  75                  80
Leu Ala His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln 
                 85                  90                  95
Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val 
             100                105                110
Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
         115                120                125



<210> 9752
<211> 631
<212> DNA
<213> Rattus norvegicus
<308> X60212
<400> 9752

ctgttagcg  ccagaggtg  cctgtgaag  tggttcgct  ctcccttga  ccagaaaac  60
ccacgaaat  atgcaagtc  agaggctca  accttcgtg  tcactttaa  aacacccgg  120
aaactgccc  ggccatcaa  ggtatgcat  tccgcaaag  caccaagta  ctgaaggat  180
tcactttaa  gaagcagtg  gtgccattc  ggcggtata  cggtggagt  ggtaggtgc  240
cccaggcca  acagtgggg  tggacacag  gacggtggc  aaaaaagag  gctgaattt  300
tgctgcaca  gcttaaaaa  gcagagagt  atgctgaac  taagggttt  gatgtagac  360
ctctggtca  tgaacacat  caggtgaac  aggctccta  gatgcgcag  cggacctac  420
gagctcacg  ccggattaa  ccatacatg  gctccccct  ccacatcga  atgatcctc  480
ctgagaagg  acagattgt  ccaaagcca  aagaggagg  tgcacagaa  aaaaagata  540
cccagaaga  attgaagaa  caaaagctc  tggcacggg  ataaattca  cataaataa  600
tgcggataa  gtaaaaaaa  aaaaaaaaa  a  631



<210> 9753
<211> 184
<212> PRT
<213> Rattus norvegicus
<308> P24049
<400> 9753

Met Val Arg Tyr Ser Leu Asp Pro Glu Asn Pro Thr Lys Ser Cys Lys 
  1               5                  10                  15
Ser Arg Gly Ser Asn Leu Arg Val His Phe Lys Asn Thr Arg Glu Thr 
             20                  25                  30
Ala Gln Ala Ile Lys Gly Met His Ile Arg Lys Ala Thr Lys Tyr Leu 
         35                  40                  45
Lys Asp Val Thr Leu Lys Lys Gln Cys Val Pro Phe Arg Arg Tyr Asn 
     50                  55                  60
Gly Gly Val Gly Arg Cys Ala Gln Ala Lys Gln Trp Gly Trp Thr Gln 
 65                  70                  75                  80
Gly Arg Trp Pro Lys Lys Ser Ala Glu Phe Leu Leu His Met Leu Lys 
                 85                  90                  95
Asn Ala Glu Ser Asn Ala Glu Leu Lys Gly Leu Asp Val Asp Ser Leu 
             100                105                110
Val Ile Glu His Ile Gln Val Asn Lys Ala Pro Lys Met Arg Arg Arg 
         115                120                125
Thr Tyr Arg Ala His Gly Arg Ile Asn Pro Tyr Met Ser Ser Pro Cys 
     130                135                140
His Ile Glu Met Ile Leu Thr Glu Lys Glu Gln Ile Val Pro Lys Pro 
 145                150                155                160
Glu Glu Glu Val Ala Gln Lys Lys Lys Ile Ser Gln Lys Lys Leu Lys 
                 165                170                175
Lys Gln Lys Leu Met Ala Arg Glu 
             180



<210> 9754
<211> 898
<212> DNA
<213> Homo sapiens
<308> NM_000985
<400> 9754

tcctctttc  ctaagcagc  tgagggttg  ctggattgg  gaggcccgt  tggctactt  60
tgtggaagc  gtgctgtag  tactggaag  taaaaggga  agcaagccc  tggtggggg  120
aagtatggc  gcgatgatg  catttctta  gacaccttt  gattaataa  gaaaacaac  180
actctctga  cagctgttc  aatcatctg  tatttatac  gaatgagtt  ctgtaagta  240
gtattgaca  aattacact  tactttcct  taggtgatc  gtgaaaatg  ttcgctatt  300
acttgaccc  gagaacccc  cgaaatcat  caaatcaag  ggttccaat  ttcgtgttc  360
ctttaagaa  actcgtgaa  ctgctcagg  catcaaggg  atgcatata  gaaaagcca  420
gaagtatct  aaagatgtc  ctttacaga  acagtgtgt  ccattccga  gttacaatg  480
tggagttgg  aggtgtgcg  aggccaagc  atggggctg  acacaaggt  ggtggccca  540
aaagagtgc  gaatttttg  tgcacatgc  taaaaacgc  gagagtaat  ctgaactta  600
gggtttaga  gtagattct  tggtcattg  gcatatcca  gtgaacaaa  cacctaaga  660
gcgccgccg  acctacaga  ctcatggtc  gattaaccc  tacatgagc  ctccctgcc  720
cattgagat  atccttacg  aaaaggaac  gattgttcc  aaaccagaa  aggaggttg  780
ccagaagaa  aagatatcc  agaagaaac  gaagaaaca  aaacttatg  cacgggagt  840
aattcagca  taaaataaa  gtaattaaa  ggaaaaaaa  aaaaaaaaa  aaaaaaaa  898



<210> 9755
<211> 184
<212> PRT
<213> Homo sapiens
<308> P18621
<400> 9755

Met Val Arg Tyr Ser Leu Asp Pro Glu Asn Pro Thr Lys Ser Cys Lys 
  1               5                  10                  15
Ser Arg Gly Ser Asn Leu Arg Val His Phe Lys Asn Thr Arg Glu Thr 
             20                  25                  30
Ala Gln Ala Ile Lys Gly Met His Ile Arg Lys Ala Thr Lys Tyr Leu 
         35                  40                  45
Lys Asp Val Thr Leu Gln Lys Gln Cys Val Pro Phe Arg Arg Tyr Asn 
     50                  55                  60
Gly Gly Val Gly Arg Cys Ala Gln Ala Lys Gln Trp Gly Trp Thr Gln 
 65                  70                  75                  80
Gly Arg Trp Pro Lys Lys Ser Ala Glu Phe Leu Leu His Met Leu Lys 
                 85                  90                  95
Asn Ala Glu Ser Asn Ala Glu Leu Lys Gly Leu Asp Val Asp Ser Leu 
             100                105                110
Val Ile Glu His Ile Gln Val Asn Lys Ala Pro Lys Met Arg Arg Arg 
         115                120                125
Thr Tyr Arg Ala His Gly Arg Ile Asn Pro Tyr Met Ser Ser Pro Cys 
     130                135                140
His Ile Glu Met Ile Leu Thr Glu Lys Glu Gln Ile Val Pro Lys Pro 
 145                150                155                160
Glu Glu Glu Val Ala Gln Lys Lys Lys Ile Ser Gln Lys Lys Leu Lys 
                 165                170                175
Lys Gln Lys Leu Met Ala Arg Glu 
             180



<210> 9756
<211> 2464
<212> DNA
<213> Rattus norvegicus
<308> X60468
<400> 9756

ttcttctcg  ccttgggtc  tggaagggg  ctggccctc  actggatga  tattgggta  60
gctgacccc  cactgagcc  cctacctgg  agattcctt  tggaacccc  acgctttcg  120
gacggattc  gatctaccg  ctggatgga  gagggtcca  gacacctca  ggacctact  180
ctggcacat  ccaacaggg  ccacccagt  ggaaccccc  ggccgggcc  ccccatcac  240
ggggaacag  ccccaagaa  agtcccagg  aaggctcaa  ggcttgttg  acaccaggg  300
tggaagggt  tgtgcttct  gaacagggt  aaactacca  cctacaccc  ttcttcctc  360
agctcacct  gactggctt  gctcaccaa  aaggctttg  ggaaggaga  ttttggaag  420
taaataaag  aaccacgtt  actctgggg  ctactggag  gggggactt  attttgggc  480
tgattcttt  atttgtttt  aaaggatga  cctagtgaa  aggccccaa  ggagttggg  540
ctgaaggac  ctgaggagg  gacattgcc  ttctcagct  agagcctca  gtgagtcag  600
tgcagcaga  tagggtgag  ctggatcta  gtttcttaa  ctaagagtg  tgtgtcaag  660
gttcccatc  gcctccagc  cagagccag  gccccagga  gaggagaat  tgccccaac  720
gaacgccaa  ccagggatc  aggtttgtt  aagaccaac  cccatttag  aagcaggcc  780
ctatgtgga  gacagacct  atgctgtgc  ttgaggaca  ctgtggtct  agcatatct  840
ccaagcaag  tcttaccag  ttcaggcaa  gccgtgtgt  tgctgaact  tcttctgac  900
gcttctgtg  ttaactcag  tgcgaaggg  ctcttaggg  ctcttaagg  ttagatcag  960
aggccatct  ttctgacca  gtcttgttt  gggaccttc  atctaagtt  agaatgtct  1020
acatgtttt  tgtgccagg  cnngagctc  tctgtgctg  gcccaaggc  cctccaatt  1080
catctcaga  ctctacccc  gaccctttt  tgtgtctgg  agtgtttcg  tgtgcgctc  1140
ctaggctgg  tagagatga  tgaggagga  ctggcccca  gacgcagca  tgtggcagt  1200
aacaattgt  tccgccagc  ctcctacca  aaaaacaat  tacatgatc  gatgtctgg  1260
ggctgggga  aggtagggc  ggactgtga  tgtgtactg  gcccactag  gtaccactg  1320
gtcccacct  ctgggtttg  agggaaagg  tctgctgct  cagctggag  atgagacgc  1380
aaagttggt  gagccacag  accagacac  gctgcatgc  cagcccatc  tcagcattc  1440
cgtgtgggg  gttgggcgg  acagtggaa  gtgggcaca  gaatcgccg  ggtggggga  1500
gctcatcca  ccagcagtt  gtccttttt  taatcatgc  ctttggctc  cttgtgctg  1560
cggacccag  gagaggtat  aacgtccat  tgctttgac  gtgcccctt  ctactcctg  1620
accggatgc  tcgaagcac  taggctccc  tactgtgtg  cctgcccct  cctcacctg  1680
tgtcctggg  cttatcccc  acctcagca  gcttgcctc  gcgctcccc  gctcctgaa  1740
gcagaccta  ggaacacca  ggcaaaccc  gtacactgt  atggacagg  aggttgagg  1800
tggaatggt  gccaggcat  cgatttggt  gttctagga  acactgagg  gaccctccc  1860
ccaaacagg  actttgcct  cgtagctcg  gataagctg  cccagatgc  caagtgcca  1920
gtgtttcgc  gtgaggcac  tgccaagaa  atcgccacc  gcctgcatg  gatctgctc  1980
aaggcacgg  cccctccat  cctgaacta  ctgtcatct  tgctctaga  ggtgtggta  2040
gttgcgttg  ggatgtagg  gggcttcgg  caatgtagc  ctaacagag  acacacacc  2100
cccccattc  ttcctcaga  catgtctga  cggcgcaat  ctcgctgct  ggtaaatgg  2160
ctctccctg  accactcta  acttgtgga  gtccctttc  aaggtgagt  ccacacgca  2220
cctcataag  cacagctca  ctttgttag  taaggtgag  tgacccaag  agaggcaca  2280
gatcctggg  aggcatgag  acatggaga  gggtgcttg  cagtacata  gtggataag  2340
ttgtagagg  aggcagggg  gaagtgggc  tgagggttg  actaggaaa  tgcatagtt  2400
atgctttag  gtcaggacc  agaacagtg  gcctctttt  ctttttctt  tcacagtgg  2460
attc  2464



<210> 9757
<211> 598
<212> PRT
<213> Rattus norvegicus
<308> CAA42998
<400> 9757

Glu Leu Ser Ala His Asn Xaa Ala Asn Arg Gly Leu His Gly Ser Ala 
  1               5                  10                  15
Lys Ile Ile Asn Thr Gln Gly Leu Gly Pro Asp Glu Gly Gly Arg Arg 
             20                  25                  30
Gln Arg Gly Glu Val Glu Glu Glu Asp Glu Asp Glu Glu Glu Glu Asp 
         35                  40                  45
Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Asp Leu Ser Ser Pro 
     50                  55                  60
Gln Gly Leu Pro Glu Pro Leu Glu Asn Val Glu Val Pro Ser Gly Pro 
 65                  70                  75                  80
Gln Val Leu Thr Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
                 85                  90                  95
Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
             100                105                110
Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr 
         115                120                125
Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro 
     130                135                140
Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His 
 145                150                155                160
Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
                 165                170                175
Ser Gln Gly Asn Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly 
             180                185                190
Phe Ala His Gln Glu Gly Phe Glu Glu Gly Glu Phe Trp Lys Asp Glu 
         195                200                205
Pro Ser Glu Glu Ala Pro Met Glu Leu Gly Leu Lys Asp Pro Glu Glu 
     210                215                220
Gly Thr Leu Pro Phe Ser Ala Gln Ser Leu Ser Pro Glu Pro Val Pro 
 225                230                235                240
Gln Glu Glu Glu Asn Leu Pro Gln Arg Asn Ala Asn Pro Gly Ile Lys 
                 245                250                255
Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu 
             260                265                270
Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
         275                280                285
Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
     290                295                300
Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys 
 305                310                315                320
Leu Val Glu Pro Gln Asn Gln Thr Leu Leu His Ala Gln Pro Ile Val 
                 325                330                335
Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp 
             340                345                350
Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His 
         355                360                365
Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His 
     370                375                380
Glu Ile Cys Ser Lys Ile Met Ser Glu Arg Arg Asn Ala Arg Cys Leu 
 385                390                395                400
Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
                 405                410                415
Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
             420                425                430
Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
         435                440                445
Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
     450                455                460
Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile 
 465                470                475                480
Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
                 485                490                495
Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile 
             500                505                510
Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
         515                520                525
Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
     530                535                540
Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Thr Ser Thr Ser Cys 
 545                550                555                560
Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr 
                 565                570                575
Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg 
             580                585                590
Leu Gly Ser Gln Thr Pro 
         595



<210> 9758
<211> 2654
<212> DNA
<213> Homo sapiens
<308> NM_001164
<400> 9758

atgttgtga  ggagaagcc  cggcggagc  cgaaccccg  agcctgagc  acctccgtc  60
tctgggccc  gggcctcac  gcgcaggag  tgccaaggc  atgtctgtt  catcatcac  120
gagccagtc  gccattaat  ccaacagcc  cggaggccc  gcactgagc  tacccctgc  180
tctgcacgc  gcccacaac  agctgctca  cgccaagct  caggccaca  ctgtgggac  240
caaggacct  cgcagcgcc  tgggggagg  tggtgggcc  gagccaggc  ctgccaatg  300
caagtggct  aaagagggc  agaaccagc  ccggcgggc  gccacggcc  accgtgacc  360
gaatcgcaa  gtgaccttg  ccttggcgg  ggaggccag  caggagcct  agatggcac  420
cttgggccc  aaaggcctg  tacacctgt  ctctgagct  gagctctca  ctcacaacg  480
agccaaccg  ggcctacga  gacctggcc  gatcatcag  actcaagag  aggggccag  540
tgagggaga  gagaaggcg  ccggggagg  cgaggagga  gaggaggat  atgatgatg  600
agaggagga  gaggactta  cttctcccc  agggctgcc  gagcccctg  agagtgtgg  660
ggccccccc  aggccccaa  cccttacag  tggcccccg  gaacacagc  agagtgcca  720
cctcctgtt  ggcatgcgg  acagtgcag  cagtgatga  gactcaagc  gggctacct  780
atctcaggg  agcccctcc  atggctccc  agaggacac  gattccttc  ggaacccca  840
cgccttcga  acggattcc  acctgccgg  tggatggat  agggtccag  acacctcag  900
gacctatta  tggcacatc  caacaggga  cacccagtg  gaacccccc  gccgggcct  960
cccctcaca  gggagcagc  cccaagagg  gtcccagct  acctggaca  gttttgctc  1020
tggagaagg  tttgaggat  gagaatttt  gaaggatga  cccagtgat  aggccccaa  1080
ggagctggg  ctgaaggaa  ctgaggagg  gacgttgac  ttcccagct  agagcctca  1140
cccagagcc  ttgccccaa  aggaggaga  gcttccccc  cggaatacc  acccaggga  1200
caagtgttt  gccgtgcgc  ccctaggct  ggtagagat  accgaggag  agctggccc  1260
tggacgcag  agtgtggca  tcaacaatt  catccgtca  ctctcttac  acaaaaaca  1320
cctgcatga  cccatgtct  ggggctggg  ggaaggaaa  gatctgcta  tgcagctgg  1380
ggatgagac  ctaaagcta  tggagccac  gagccaggc  ctgctgcac  cccaaccca  1440
catcagcat  cgcgtgtgg  gcgtcgggc  ggacagtgg  agagagagg  actttgcct  1500
cgtagctcg  gataagctg  cccagatgc  caagtgcca  gtgtttcgc  gtgaggcac  1560
tgccaagaa  atcgccacc  gcctgcatg  gatctgctc  aagatcatg  ccgaacggc  1620
taatgcccg  tgcttggta  atggactct  cctggacca  tctaaactt  tggatgtcc  1680
tttccaagt  gaattccca  cgcctaaga  tgagttggt  cagaagttc  aagtctatt  1740
cctggggaa  gtacctgtt  ctaaacctg  tggggtaga  gtgattaat  gggccctcg  1800
gtcagtcct  tcctccagc  gccgtgaac  atggacccc  agtcatgtc  gtgtggccc  1860
tgctaccct  accatcttg  accagcaga  agaggcagt  ctgggagag  gtcgggtgc  1920
tttcctctc  ttcctggcc  tgggcagag  tgtccacac  tttgcattc  tcatggctg  1980
cggcccagc  tccttctgc  gccacatgt  ctggtgcga  cccaatgct  ccagcctct  2040
agaggctgt  caggctgcg  gcatgcttc  ctaccagaa  tgtctggat  cccgttccc  2100
ggcctccac  tcctgcctc  cagcacccc  tgctgagtc  gtggcacgg  gtgtagggt  2160
gactgtccg  aggggtgtt  agtcgctgt  gggctccct  aagcccaaa  ggctggggg  2220
ccatacccc  tgaagaagc  cccaccttc  cttccacct  attgtgttg  gccccaggg  2280
actaaaggg  gtgggtcag  gaggggtct  gaggctatt  ctaggcctc  ggcctccca  2340
atatgcccc  ccccagtag  tacggttcc  tgcctagga  ctggggagg  agagatcta  2400
tcccttcaa  gaagtgata  cactggagt  gtaacaaga  gagcaggaa  caaggccag  2460
cctggttct  catccccat  tgtttcagg  ggaacagga  gaactggtc  aggccaggc  2520
tcatcctcc  ggacccagc  ggggcagaa  gaggaaggg  ctggtccag  catgggtcc  2580
ttccccctg  tccatgggc  cctctgctg  attgatatc  ctaataaag  ctgtctgca  2640
tgcaaaaaa  aaaa  2654



<210> 9759
<211> 710
<212> PRT
<213> Homo sapiens
<308> O00213
<400> 9759

Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
  1               5                  10                  15
His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
             20                  25                  30
Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Thr Ala Val Gly Pro Lys 
         35                  40                  45
Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
     50                  55                  60
Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
 65                  70                  75                  80
Ala Thr Ala His Arg Asp Gln Asn Arg Asn Val Thr Leu Thr Leu Ala 
                 85                  90                  95
Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
             100                105                110
Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
         115                120                125
Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Thr Gln Glu Gln 
     130                135                140
Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
 145                150                155                160
Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                 165                170                175
Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
             180                185                190
Gln Ala Leu Thr Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
         195                200                205
Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
     210                215                220
Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr 
 225                230                235                240
Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro 
                 245                250                255
Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His 
             260                265                270
Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
         275                280                285
Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly 
     290                295                300
Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
 305                310                315                320
Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                 325                330                335
Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
             340                345                350
Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys 
         355                360                365
Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu 
     370                375                380
Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
 385                390                395                400
Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                 405                410                415
Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys 
             420                425                430
Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
         435                440                445
Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp 
     450                455                460
Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His 
 465                470                475                480
Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His 
                 485                490                495
Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu 
             500                505                510
Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
         515                520                525
Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
     530                535                540
Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
 545                550                555                560
Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
                 565                570                575
Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile 
             580                585                590
Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
         595                600                605
Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile 
     610                615                620
Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
 625                630                635                640
Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
                 645                650                655
Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys 
             660                665                670
Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr 
         675                680                685
Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg 
     690                695                700
Leu Gly Ala His Thr Pro 
 705                710



<210> 9760
<211> 2249
<212> DNA
<213> Rattus norvegicus
<308> X60469
<400> 9760

aaaggtcca  gcttaatgg  tgtatactc  tgactgagc  ctcggccca  aatcagcca  60
ccgagggct  catggatcc  ccaagatca  caacaccca  ggactggga  cagatgaag  120
agggagaag  cagcgagga  aagttgagg  ggaggatga  gatgaggag  aagaggatg  180
ggaggagga  gaagaggat  aggaggagg  ggacttgtc  tctcctcaa  ggctacctg  240
gcctctgga  aatgtggaa  tcccctctg  accccaggt  ctcacagat  gcccccggg  300
acatagcaa  agtgctagc  tcctatttg  catgcgaaa  agtgcagcc  gtgacgagg  360
ctcaagctg  gccacctta  cgcagggca  cccctccta  ggctctccg  aggacacag  420
ttccttctg  aaccccaac  ctttcgaga  ggattccga  ctaccggct  gatggatga  480
ggtccaaga  acctcaggg  cctactact  gcacatccc  acagggacc  cccagtggg  540
acccccagg  cgggcctcc  catcacagg  gaacagtcc  caagaagag  cccagctca  600
ctggactgg  tttgctcac  aagaaggct  tgaggaagg  gagttttgg  aggatgaac  660
tagtgaaga  gccccaatg  agttgggac  gaaggaccc  gaggagggg  cattgccct  720
ctcagctca  agcctcagc  cagagccag  gccccagga  gaggagaat  tgccccaac  780
gaacgccaa  ccagggatc  agtgtttcg  tgtgcgctc  ctaggctgg  tagagatga  840
tgaggagga  ctggcccca  gacgcagca  tgtggcagt  aacaattgt  tccgccagc  900
ctcctacca  aaaaacaat  tacatgatc  gatgtctgg  ggctgggga  agggaaagg  960
tctgctgct  cagctggag  atgagacgc  aaagttggt  gagccacag  accagacac  1020
gctgcatgc  cagcccatc  tcagcattc  cgtgtgggg  gttgggcgg  acagtggaa  1080
agagaggga  tttgcctac  tagctcgag  taagctgac  cagatgctc  agtgccacg  1140
gtttcgctg  gaggcacct  ccaagaaca  cgccaccag  ctgcatgag  tctgctcca  1200
gatcatgtc  gaacggcgc  atgctcgct  cttggtaaa  ggactctcc  tggaccact  1260
taaacttgt  gatgtccct  tccaagtgg  attcccagc  ccaaagaat  aactggtgc  1320
gaagtttca  gtctattac  tagggaacg  gcctgtggc  aaacccgtt  gggtagatg  1380
gattaatgg  gccctggag  cagtcctgt  ttccagtag  cgtgagcag  ggaccccaa  1440
tcacgtcag  gtggcccct  ccaccctca  catcttgca  cagcagaca  aagcagtgc  1500
gggggagtg  cgagtgcgg  tcctctcct  cctggctgt  ggcagagat  tgcacacgt  1560
cgcattcat  atggctgcc  gcccagcct  cttctgctg  cacatgttt  ggtgcgagc  1620
caatgctgc  agtctctcg  aggctgtgc  ggctgcatg  atgctccgc  accagaagt  1680
tctggatgc  cgttcccag  cctccacct  ctgcctccc  gcaccccct  cggagtcag  1740
tgcgagacg  gtagggtgg  ctgtccgca  gggtgttca  tctctgtgg  gttccctca  1800
gcccaaacg  ctaggatcc  agaccccat  aagagctcc  atcctccct  tacctgctt  1860
ttttgggcc  cagggaact  aagggtttg  ggcaggtag  ggctgtgga  gttcttcct  1920
caccccatg  cccccgggc  gcccctcct  agtagctgg  gttccctac  taggggctg  1980
gagagagaa  ttgaattcc  tcacagaag  cattacact  gactgatga  atcggggcc  2040
agaagcaaa  ccagccttg  gctctccat  cccagtgtt  gaggtggag  aggaggaac  2100
ggtccaagc  aggccccat  ctcaaaggc  caataaggg  aggagggga  tggtctcgg  2160
atggatccc  tgtcccctg  tctgcggac  cctccactg  actgatatc  ctaataaag  2220
ctgtctgtc  ctgaaaaaa  aaaaaaaaa  2249



<210> 9761
<211> 598
<212> PRT
<213> Rattus norvegicus
<308> CAA42999
<400> 9761

Glu Leu Ser Ala His Asn Xaa Ala Asn Arg Gly Leu His Gly Ser Ala 
  1               5                  10                  15
Lys Ile Ile Asn Thr Gln Gly Leu Gly Pro Asp Glu Gly Gly Arg Arg 
             20                  25                  30
Gln Arg Gly Glu Val Glu Glu Glu Asp Glu Asp Glu Glu Glu Glu Asp 
         35                  40                  45
Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Asp Leu Ser Ser Pro 
     50                  55                  60
Gln Gly Leu Pro Glu Pro Leu Glu Asn Val Glu Val Pro Ser Gly Pro 
 65                  70                  75                  80
Gln Val Leu Thr Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
                 85                  90                  95
Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
             100                105                110
Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr 
         115                120                125
Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro 
     130                135                140
Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His 
 145                150                155                160
Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
                 165                170                175
Ser Gln Gly Asn Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly 
             180                185                190
Phe Ala His Gln Glu Gly Phe Glu Glu Gly Glu Phe Trp Lys Asp Glu 
         195                200                205
Pro Ser Glu Glu Ala Pro Met Glu Leu Gly Leu Lys Asp Pro Glu Glu 
     210                215                220
Gly Thr Leu Pro Phe Ser Ala Gln Ser Leu Ser Pro Glu Pro Val Pro 
 225                230                235                240
Gln Glu Glu Glu Asn Leu Pro Gln Arg Asn Ala Asn Pro Gly Ile Lys 
                 245                250                255
Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu 
             260                265                270
Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
         275                280                285
Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
     290                295                300
Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys 
 305                310                315                320
Leu Val Glu Pro Gln Asn Gln Thr Leu Leu His Ala Gln Pro Ile Val 
                 325                330                335
Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp 
             340                345                350
Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His 
         355                360                365
Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His 
     370                375                380
Glu Ile Cys Ser Lys Ile Met Ser Glu Arg Arg Asn Ala Arg Cys Leu 
 385                390                395                400
Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
                 405                410                415
Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
             420                425                430
Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
         435                440                445
Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
     450                455                460
Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile 
 465                470                475                480
Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
                 485                490                495
Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile 
             500                505                510
Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
         515                520                525
Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
     530                535                540
Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Thr Ser Thr Ser Cys 
 545                550                555                560
Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr 
                 565                570                575
Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg 
             580                585                590
Leu Gly Ser Gln Thr Pro 
         595



<210> 9762
<211> 2654
<212> DNA
<213> Homo sapiens
<308> NM_001164
<400> 9762

atgttgtga  ggagaagcc  cggcggagc  cgaaccccg  agcctgagc  acctccgtc  60
tctgggccc  gggcctcac  gcgcaggag  tgccaaggc  atgtctgtt  catcatcac  120
gagccagtc  gccattaat  ccaacagcc  cggaggccc  gcactgagc  tacccctgc  180
tctgcacgc  gcccacaac  agctgctca  cgccaagct  caggccaca  ctgtgggac  240
caaggacct  cgcagcgcc  tgggggagg  tggtgggcc  gagccaggc  ctgccaatg  300
caagtggct  aaagagggc  agaaccagc  ccggcgggc  gccacggcc  accgtgacc  360
gaatcgcaa  gtgaccttg  ccttggcgg  ggaggccag  caggagcct  agatggcac  420
cttgggccc  aaaggcctg  tacacctgt  ctctgagct  gagctctca  ctcacaacg  480
agccaaccg  ggcctacga  gacctggcc  gatcatcag  actcaagag  aggggccag  540
tgagggaga  gagaaggcg  ccggggagg  cgaggagga  gaggaggat  atgatgatg  600
agaggagga  gaggactta  cttctcccc  agggctgcc  gagcccctg  agagtgtgg  660
ggccccccc  aggccccaa  cccttacag  tggcccccg  gaacacagc  agagtgcca  720
cctcctgtt  ggcatgcgg  acagtgcag  cagtgatga  gactcaagc  gggctacct  780
atctcaggg  agcccctcc  atggctccc  agaggacac  gattccttc  ggaacccca  840
cgccttcga  acggattcc  acctgccgg  tggatggat  agggtccag  acacctcag  900
gacctatta  tggcacatc  caacaggga  cacccagtg  gaacccccc  gccgggcct  960
cccctcaca  gggagcagc  cccaagagg  gtcccagct  acctggaca  gttttgctc  1020
tggagaagg  tttgaggat  gagaatttt  gaaggatga  cccagtgat  aggccccaa  1080
ggagctggg  ctgaaggaa  ctgaggagg  gacgttgac  ttcccagct  agagcctca  1140
cccagagcc  ttgccccaa  aggaggaga  gcttccccc  cggaatacc  acccaggga  1200
caagtgttt  gccgtgcgc  ccctaggct  ggtagagat  accgaggag  agctggccc  1260
tggacgcag  agtgtggca  tcaacaatt  catccgtca  ctctcttac  acaaaaaca  1320
cctgcatga  cccatgtct  ggggctggg  ggaaggaaa  gatctgcta  tgcagctgg  1380
ggatgagac  ctaaagcta  tggagccac  gagccaggc  ctgctgcac  cccaaccca  1440
catcagcat  cgcgtgtgg  gcgtcgggc  ggacagtgg  agagagagg  actttgcct  1500
cgtagctcg  gataagctg  cccagatgc  caagtgcca  gtgtttcgc  gtgaggcac  1560
tgccaagaa  atcgccacc  gcctgcatg  gatctgctc  aagatcatg  ccgaacggc  1620
taatgcccg  tgcttggta  atggactct  cctggacca  tctaaactt  tggatgtcc  1680
tttccaagt  gaattccca  cgcctaaga  tgagttggt  cagaagttc  aagtctatt  1740
cctggggaa  gtacctgtt  ctaaacctg  tggggtaga  gtgattaat  gggccctcg  1800
gtcagtcct  tcctccagc  gccgtgaac  atggacccc  agtcatgtc  gtgtggccc  1860
tgctaccct  accatcttg  accagcaga  agaggcagt  ctgggagag  gtcgggtgc  1920
tttcctctc  ttcctggcc  tgggcagag  tgtccacac  tttgcattc  tcatggctg  1980
cggcccagc  tccttctgc  gccacatgt  ctggtgcga  cccaatgct  ccagcctct  2040
agaggctgt  caggctgcg  gcatgcttc  ctaccagaa  tgtctggat  cccgttccc  2100
ggcctccac  tcctgcctc  cagcacccc  tgctgagtc  gtggcacgg  gtgtagggt  2160
gactgtccg  aggggtgtt  agtcgctgt  gggctccct  aagcccaaa  ggctggggg  2220
ccatacccc  tgaagaagc  cccaccttc  cttccacct  attgtgttg  gccccaggg  2280
actaaaggg  gtgggtcag  gaggggtct  gaggctatt  ctaggcctc  ggcctccca  2340
atatgcccc  ccccagtag  tacggttcc  tgcctagga  ctggggagg  agagatcta  2400
tcccttcaa  gaagtgata  cactggagt  gtaacaaga  gagcaggaa  caaggccag  2460
cctggttct  catccccat  tgtttcagg  ggaacagga  gaactggtc  aggccaggc  2520
tcatcctcc  ggacccagc  ggggcagaa  gaggaaggg  ctggtccag  catgggtcc  2580
ttccccctg  tccatgggc  cctctgctg  attgatatc  ctaataaag  ctgtctgca  2640
tgcaaaaaa  aaaa  2654



<210> 9763
<211> 710
<212> PRT
<213> Homo sapiens
<308> O00213
<400> 9763

Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
  1               5                  10                  15
His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
             20                  25                  30
Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Thr Ala Val Gly Pro Lys 
         35                  40                  45
Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
     50                  55                  60
Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
 65                  70                  75                  80
Ala Thr Ala His Arg Asp Gln Asn Arg Asn Val Thr Leu Thr Leu Ala 
                 85                  90                  95
Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
             100                105                110
Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
         115                120                125
Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Thr Gln Glu Gln 
     130                135                140
Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
 145                150                155                160
Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                 165                170                175
Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
             180                185                190
Gln Ala Leu Thr Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
         195                200                205
Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
     210                215                220
Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr 
 225                230                235                240
Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro 
                 245                250                255
Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His 
             260                265                270
Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
         275                280                285
Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly 
     290                295                300
Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
 305                310                315                320
Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                 325                330                335
Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
             340                345                350
Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys 
         355                360                365
Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu 
     370                375                380
Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
 385                390                395                400
Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                 405                410                415
Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys 
             420                425                430
Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
         435                440                445
Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp 
     450                455                460
Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His 
 465                470                475                480
Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His 
                 485                490                495
Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu 
             500                505                510
Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
         515                520                525
Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
     530                535                540
Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
 545                550                555                560
Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
                 565                570                575
Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile 
             580                585                590
Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
         595                600                605
Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile 
     610                615                620
Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
 625                630                635                640
Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
                 645                650                655
Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys 
             660                665                670
Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr 
         675                680                685
Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg 
     690                695                700
Leu Gly Ala His Thr Pro 
 705                710



<210> 9764
<211> 2249
<212> DNA
<213> Rattus norvegicus
<308> X60469
<400> 9764

aaaggtcca  gcttaatgg  tgtatactc  tgactgagc  ctcggccca  aatcagcca  60
ccgagggct  catggatcc  ccaagatca  caacaccca  ggactggga  cagatgaag  120
agggagaag  cagcgagga  aagttgagg  ggaggatga  gatgaggag  aagaggatg  180
ggaggagga  gaagaggat  aggaggagg  ggacttgtc  tctcctcaa  ggctacctg  240
gcctctgga  aatgtggaa  tcccctctg  accccaggt  ctcacagat  gcccccggg  300
acatagcaa  agtgctagc  tcctatttg  catgcgaaa  agtgcagcc  gtgacgagg  360
ctcaagctg  gccacctta  cgcagggca  cccctccta  ggctctccg  aggacacag  420
ttccttctg  aaccccaac  ctttcgaga  ggattccga  ctaccggct  gatggatga  480
ggtccaaga  acctcaggg  cctactact  gcacatccc  acagggacc  cccagtggg  540
acccccagg  cgggcctcc  catcacagg  gaacagtcc  caagaagag  cccagctca  600
ctggactgg  tttgctcac  aagaaggct  tgaggaagg  gagttttgg  aggatgaac  660
tagtgaaga  gccccaatg  agttgggac  gaaggaccc  gaggagggg  cattgccct  720
ctcagctca  agcctcagc  cagagccag  gccccagga  gaggagaat  tgccccaac  780
gaacgccaa  ccagggatc  agtgtttcg  tgtgcgctc  ctaggctgg  tagagatga  840
tgaggagga  ctggcccca  gacgcagca  tgtggcagt  aacaattgt  tccgccagc  900
ctcctacca  aaaaacaat  tacatgatc  gatgtctgg  ggctgggga  agggaaagg  960
tctgctgct  cagctggag  atgagacgc  aaagttggt  gagccacag  accagacac  1020
gctgcatgc  cagcccatc  tcagcattc  cgtgtgggg  gttgggcgg  acagtggaa  1080
agagaggga  tttgcctac  tagctcgag  taagctgac  cagatgctc  agtgccacg  1140
gtttcgctg  gaggcacct  ccaagaaca  cgccaccag  ctgcatgag  tctgctcca  1200
gatcatgtc  gaacggcgc  atgctcgct  cttggtaaa  ggactctcc  tggaccact  1260
taaacttgt  gatgtccct  tccaagtgg  attcccagc  ccaaagaat  aactggtgc  1320
gaagtttca  gtctattac  tagggaacg  gcctgtggc  aaacccgtt  gggtagatg  1380
gattaatgg  gccctggag  cagtcctgt  ttccagtag  cgtgagcag  ggaccccaa  1440
tcacgtcag  gtggcccct  ccaccctca  catcttgca  cagcagaca  aagcagtgc  1500
gggggagtg  cgagtgcgg  tcctctcct  cctggctgt  ggcagagat  tgcacacgt  1560
cgcattcat  atggctgcc  gcccagcct  cttctgctg  cacatgttt  ggtgcgagc  1620
caatgctgc  agtctctcg  aggctgtgc  ggctgcatg  atgctccgc  accagaagt  1680
tctggatgc  cgttcccag  cctccacct  ctgcctccc  gcaccccct  cggagtcag  1740
tgcgagacg  gtagggtgg  ctgtccgca  gggtgttca  tctctgtgg  gttccctca  1800
gcccaaacg  ctaggatcc  agaccccat  aagagctcc  atcctccct  tacctgctt  1860
ttttgggcc  cagggaact  aagggtttg  ggcaggtag  ggctgtgga  gttcttcct  1920
caccccatg  cccccgggc  gcccctcct  agtagctgg  gttccctac  taggggctg  1980
gagagagaa  ttgaattcc  tcacagaag  cattacact  gactgatga  atcggggcc  2040
agaagcaaa  ccagccttg  gctctccat  cccagtgtt  gaggtggag  aggaggaac  2100
ggtccaagc  aggccccat  ctcaaaggc  caataaggg  aggagggga  tggtctcgg  2160
atggatccc  tgtcccctg  tctgcggac  cctccactg  actgatatc  ctaataaag  2220
ctgtctgtc  ctgaaaaaa  aaaaaaaaa  2249



<210> 9765
<211> 598
<212> PRT
<213> Rattus norvegicus
<308> CAA42999
<400> 9765

Glu Leu Ser Ala His Asn Xaa Ala Asn Arg Gly Leu His Gly Ser Ala 
  1               5                  10                  15
Lys Ile Ile Asn Thr Gln Gly Leu Gly Pro Asp Glu Gly Gly Arg Arg 
             20                  25                  30
Gln Arg Gly Glu Val Glu Glu Glu Asp Glu Asp Glu Glu Glu Glu Asp 
         35                  40                  45
Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Asp Leu Ser Ser Pro 
     50                  55                  60
Gln Gly Leu Pro Glu Pro Leu Glu Asn Val Glu Val Pro Ser Gly Pro 
 65                  70                  75                  80
Gln Val Leu Thr Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
                 85                  90                  95
Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
             100                105                110
Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr 
         115                120                125
Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro 
     130                135                140
Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His 
 145                150                155                160
Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
                 165                170                175
Ser Gln Gly Asn Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly 
             180                185                190
Phe Ala His Gln Glu Gly Phe Glu Glu Gly Glu Phe Trp Lys Asp Glu 
         195                200                205
Pro Ser Glu Glu Ala Pro Met Glu Leu Gly Leu Lys Asp Pro Glu Glu 
     210                215                220
Gly Thr Leu Pro Phe Ser Ala Gln Ser Leu Ser Pro Glu Pro Val Pro 
 225                230                235                240
Gln Glu Glu Glu Asn Leu Pro Gln Arg Asn Ala Asn Pro Gly Ile Lys 
                 245                250                255
Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu 
             260                265                270
Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
         275                280                285
Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
     290                295                300
Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys 
 305                310                315                320
Leu Val Glu Pro Gln Asn Gln Thr Leu Leu His Ala Gln Pro Ile Val 
                 325                330                335
Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp 
             340                345                350
Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His 
         355                360                365
Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His 
     370                375                380
Glu Ile Cys Ser Lys Ile Met Ser Glu Arg Arg Asn Ala Arg Cys Leu 
 385                390                395                400
Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
                 405                410                415
Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
             420                425                430
Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
         435                440                445
Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
     450                455                460
Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile 
 465                470                475                480
Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
                 485                490                495
Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile 
             500                505                510
Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
         515                520                525
Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
     530                535                540
Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Thr Ser Thr Ser Cys 
 545                550                555                560
Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr 
                 565                570                575
Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg 
             580                585                590
Leu Gly Ser Gln Thr Pro 
         595



<210> 9766
<211> 2654
<212> DNA
<213> Homo sapiens
<308> NM_001164
<400> 9766

atgttgtga  ggagaagcc  cggcggagc  cgaaccccg  agcctgagc  acctccgtc  60
tctgggccc  gggcctcac  gcgcaggag  tgccaaggc  atgtctgtt  catcatcac  120
gagccagtc  gccattaat  ccaacagcc  cggaggccc  gcactgagc  tacccctgc  180
tctgcacgc  gcccacaac  agctgctca  cgccaagct  caggccaca  ctgtgggac  240
caaggacct  cgcagcgcc  tgggggagg  tggtgggcc  gagccaggc  ctgccaatg  300
caagtggct  aaagagggc  agaaccagc  ccggcgggc  gccacggcc  accgtgacc  360
gaatcgcaa  gtgaccttg  ccttggcgg  ggaggccag  caggagcct  agatggcac  420
cttgggccc  aaaggcctg  tacacctgt  ctctgagct  gagctctca  ctcacaacg  480
agccaaccg  ggcctacga  gacctggcc  gatcatcag  actcaagag  aggggccag  540
tgagggaga  gagaaggcg  ccggggagg  cgaggagga  gaggaggat  atgatgatg  600
agaggagga  gaggactta  cttctcccc  agggctgcc  gagcccctg  agagtgtgg  660
ggccccccc  aggccccaa  cccttacag  tggcccccg  gaacacagc  agagtgcca  720
cctcctgtt  ggcatgcgg  acagtgcag  cagtgatga  gactcaagc  gggctacct  780
atctcaggg  agcccctcc  atggctccc  agaggacac  gattccttc  ggaacccca  840
cgccttcga  acggattcc  acctgccgg  tggatggat  agggtccag  acacctcag  900
gacctatta  tggcacatc  caacaggga  cacccagtg  gaacccccc  gccgggcct  960
cccctcaca  gggagcagc  cccaagagg  gtcccagct  acctggaca  gttttgctc  1020
tggagaagg  tttgaggat  gagaatttt  gaaggatga  cccagtgat  aggccccaa  1080
ggagctggg  ctgaaggaa  ctgaggagg  gacgttgac  ttcccagct  agagcctca  1140
cccagagcc  ttgccccaa  aggaggaga  gcttccccc  cggaatacc  acccaggga  1200
caagtgttt  gccgtgcgc  ccctaggct  ggtagagat  accgaggag  agctggccc  1260
tggacgcag  agtgtggca  tcaacaatt  catccgtca  ctctcttac  acaaaaaca  1320
cctgcatga  cccatgtct  ggggctggg  ggaaggaaa  gatctgcta  tgcagctgg  1380
ggatgagac  ctaaagcta  tggagccac  gagccaggc  ctgctgcac  cccaaccca  1440
catcagcat  cgcgtgtgg  gcgtcgggc  ggacagtgg  agagagagg  actttgcct  1500
cgtagctcg  gataagctg  cccagatgc  caagtgcca  gtgtttcgc  gtgaggcac  1560
tgccaagaa  atcgccacc  gcctgcatg  gatctgctc  aagatcatg  ccgaacggc  1620
taatgcccg  tgcttggta  atggactct  cctggacca  tctaaactt  tggatgtcc  1680
tttccaagt  gaattccca  cgcctaaga  tgagttggt  cagaagttc  aagtctatt  1740
cctggggaa  gtacctgtt  ctaaacctg  tggggtaga  gtgattaat  gggccctcg  1800
gtcagtcct  tcctccagc  gccgtgaac  atggacccc  agtcatgtc  gtgtggccc  1860
tgctaccct  accatcttg  accagcaga  agaggcagt  ctgggagag  gtcgggtgc  1920
tttcctctc  ttcctggcc  tgggcagag  tgtccacac  tttgcattc  tcatggctg  1980
cggcccagc  tccttctgc  gccacatgt  ctggtgcga  cccaatgct  ccagcctct  2040
agaggctgt  caggctgcg  gcatgcttc  ctaccagaa  tgtctggat  cccgttccc  2100
ggcctccac  tcctgcctc  cagcacccc  tgctgagtc  gtggcacgg  gtgtagggt  2160
gactgtccg  aggggtgtt  agtcgctgt  gggctccct  aagcccaaa  ggctggggg  2220
ccatacccc  tgaagaagc  cccaccttc  cttccacct  attgtgttg  gccccaggg  2280
actaaaggg  gtgggtcag  gaggggtct  gaggctatt  ctaggcctc  ggcctccca  2340
atatgcccc  ccccagtag  tacggttcc  tgcctagga  ctggggagg  agagatcta  2400
tcccttcaa  gaagtgata  cactggagt  gtaacaaga  gagcaggaa  caaggccag  2460
cctggttct  catccccat  tgtttcagg  ggaacagga  gaactggtc  aggccaggc  2520
tcatcctcc  ggacccagc  ggggcagaa  gaggaaggg  ctggtccag  catgggtcc  2580
ttccccctg  tccatgggc  cctctgctg  attgatatc  ctaataaag  ctgtctgca  2640
tgcaaaaaa  aaaa  2654



<210> 9767
<211> 710
<212> PRT
<213> Homo sapiens
<308> O00213
<400> 9767

Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
  1               5                  10                  15
His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
             20                  25                  30
Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Thr Ala Val Gly Pro Lys 
         35                  40                  45
Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
     50                  55                  60
Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
 65                  70                  75                  80
Ala Thr Ala His Arg Asp Gln Asn Arg Asn Val Thr Leu Thr Leu Ala 
                 85                  90                  95
Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
             100                105                110
Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
         115                120                125
Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Thr Gln Glu Gln 
     130                135                140
Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
 145                150                155                160
Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                 165                170                175
Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
             180                185                190
Gln Ala Leu Thr Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
         195                200                205
Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
     210                215                220
Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr 
 225                230                235                240
Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro 
                 245                250                255
Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His 
             260                265                270
Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
         275                280                285
Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly 
     290                295                300
Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
 305                310                315                320
Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                 325                330                335
Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
             340                345                350
Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys 
         355                360                365
Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu 
     370                375                380
Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
 385                390                395                400
Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                 405                410                415
Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys 
             420                425                430
Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
         435                440                445
Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp 
     450                455                460
Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His 
 465                470                475                480
Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His 
                 485                490                495
Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu 
             500                505                510
Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
         515                520                525
Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
     530                535                540
Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
 545                550                555                560
Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
                 565                570                575
Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile 
             580                585                590
Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
         595                600                605
Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile 
     610                615                620
Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
 625                630                635                640
Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
                 645                650                655
Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys 
             660                665                670
Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr 
         675                680                685
Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg 
     690                695                700
Leu Gly Ala His Thr Pro 
 705                710



<210> 9768
<211> 1184
<212> DNA
<213> Rattus norvegicus
<308> X60767
<400> 9768

ctcggcctc  aagctcccg  agtcgctgc  tccgcgcag  ccggaactc  tgtggccac  60
gcgggaaca  agagggtcc  ttgtaacct  ttgagtaac  atggaggac  atatcaaaa  120
agagaaaat  ggagaaggg  cttatggtg  ggtatataa  ggtagacac  ggactactg  180
ccagatcgt  gccatgaag  aaatcagac  tgaaagcga  gaagaagga  tgcccagta  240
ggcaatccg  gaaatctct  tgttaaaag  acttcgaca  ccaaatata  tcagcctgc  300
ggatgtact  atgcaggac  ccaggctgt  tctcatctt  gagttcctg  ccatggatc  360
caagaagta  ctggactct  tccctcctg  ccagttcat  gattcttcg  tcgttaaga  420
ttacttgta  caaatcctc  aggggattg  gttttgtca  tcccgacga  ttcttcaca  480
agacttgaa  cctcaaaat  tattgattg  tgacaaagg  acaatcaaa  tggcagatt  540
cggccttgc  agagcgttt  gaataccga  aagagtgta  acacacgag  tagtgacgc  600
gtggtaccg  tcgccagag  tgttgctgg  ctcggctcg  tactccacc  cggttgaca  660
ctggagcat  gggaccata  ttgcagagc  ggcgaccaa  aagccgctt  tccacggcg  720
ctcagagat  gaccagctc  tcaggatct  cagagctct  ggcacccct  acaacgaag  780
gtggccaga  gtagagtcc  tgcaggact  caagaacac  ttccccaag  ggaagccgg  840
gagcctcgc  tcccacgtc  agaacctgg  tgaaaacgg  ttggacttg  tctcgaaaa  900
gctggtcta  gatccagcc  aacgaatct  tggaaaaat  gcccttaag  acccatact  960
tgacgactt  gacaatcag  tcaagaaga  gtaaccctc  ggaagtccc  ccctgctgt  1020
gcagggaag  tcgtggcgt  tactgttgg  tcttcctgt  ttgtatagt  ttcttttct  1080
tgtctgtaa  ccatcatct  gacttttcc  attttccta  gtataactt  attaacatg  1140
aaatattat  ccatatgaa  ttaaatata  ttctgtata  gtgt  1184



<210> 9769
<211> 297
<212> PRT
<213> Rattus norvegicus
<308> P39951
<400> 9769

Met Glu Asp Tyr Ile Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
  1               5                  10                  15
Val Val Tyr Lys Gly Arg His Arg Thr Thr Gly Gln Ile Val Ala Met 
             20                  25                  30
Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala 
         35                  40                  45
Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
     50                  55                  60
Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
 65                  70                  75                  80
Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                 85                  90                  95
Gly Gln Phe Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile 
             100                105                110
Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
         115                120                125
Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 
     130                135                140
Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
 145                150                155                160
Thr His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                 165                170                175
Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr 
             180                185                190
Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser 
         195                200                205
Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn 
     210                215                220
Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr 
 225                230                235                240
Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu 
                 245                250                255
Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Val Tyr Asp Pro 
             260                265                270
Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Lys His Pro Tyr Phe Asp 
         275                280                285
Asp Leu Asp Asn Gln Ile Lys Lys Met 
     290                295



<210> 9770
<211> 1050
<212> DNA
<213> Homo sapiens
<308> X05360
<400> 9770

ggggggggg  ggcacttgg  ttcaaagct  gctcttgga  attgagcgg  gacgagcgg  60
ttgttgtag  tgccgtgcg  ccgccgcgg  ataataagc  gggatctac  ataccattg  120
ctaactatg  aagattata  caaaataga  aaaattgga  aaggtacct  tggagttgt  180
tataagggt  gacacaaaa  tacaggtca  gtggtagcc  tgaaaaaaa  cagactaga  240
agtgaagag  aaggggttc  tagtactgc  attcgggaa  tttctctat  aaaggaact  300
cgtcatcca  atatagtca  tcttcagga  gtgcttatg  aggattcca  gttatatct  360
atctttgag  ttctttcca  ggatctgaa  aaatacttg  attctatcc  tcctggtca  420
tacatggat  cttcacttg  taagagtta  ttataccaa  tcctacagg  gattgtgtt  480
tgtcactct  gaagagttc  tcacagaga  ttaaaacct  aaaatctct  gattgatga  540
aaaggaaca  ttaaactgg  tgattttgg  cttgccaga  cttttggaa  acctatcag  600
gtatataca  atgaggtag  aacactctg  tacagatct  cagaagtat  gctggggtc  660
gctcgttac  caactccag  tgacatttg  agtataggc  ccatatttg  tgaactagc  720
actaagaaa  cacttttcc  tggggattc  gaaattgat  aactcttca  gattttcag  780
gctttgggc  ctcccaata  tgaagtgtg  ccagaagtg  aatctttac  ggactataa  840
aatacattt  ccaaatgga  accaggaag  ctagcatcc  atgtcaaaa  cttggatga  900
aatggcttg  atttgctct  gaaaatgtt  atctatgat  cagccaaac  aatttctgg  960
aaaatggca  tgaatcatc  atattttaa  gatttggac  atcagatta  gaagatgta  1020
ctttctgac  aaaagtttc  atatgttatg  1050



<210> 9771
<211> 297
<212> PRT
<213> Homo sapiens
<308> P06493
<400> 9771

Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
  1               5                  10                  15
Val Val Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met 
             20                  25                  30
Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala 
         35                  40                  45
Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
     50                  55                  60
Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
 65                  70                  75                  80
Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                 85                  90                  95
Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile 
             100                105                110
Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
         115                120                125
Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 
     130                135                140
Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
 145                150                155                160
Thr His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                 165                170                175
Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr 
             180                185                190
Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser 
         195                200                205
Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn 
     210                215                220
Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr 
 225                230                235                240
Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu 
                 245                250                255
Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Ile Tyr Asp Pro 
             260                265                270
Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Asn His Pro Tyr Phe Asn 
         275                280                285
Asp Leu Asp Asn Gln Ile Lys Lys Met 
     290                295



<210> 9772
<211> 1194
<212> DNA
<213> Rattus norvegicus
<308> X60769
<400> 9772

ttcgccgcg  ccgcgcccg  gcaccacga  ttcctttcc  acctcttcg  cgacgacta  60
ggcgccaag  cgagcaaga  gccgtccga  tacggttac  tgagcctcg  ccgcgcggg  120
gccaaggcc  caccgcccg  ctgcttccc  ccgccgcct  ccgccgcac  caaggccga  180
ccgggcttc  aacccgcgg  ctgcaagcg  gcggacgac  cgcccgcca  ggcggccgg  240
ttcccgttc  ccctgcgcg  ctacctggg  taccaggcg  cgccgagcg  cagcagcgg  300
agcctgtcc  cgtcgtcgt  gtccagccc  cccgggacg  cgagccccg  cgacgccaa  360
gccgcgccc  ccgcctgct  cgcggggcc  ccggccgcg  ccgccaagg  caaggccaa  420
aaggcggtg  acaagctga  cgacgagta  aagatgcgg  gcgagcgca  caacatcgc  480
gtgcgcaag  gccgcgaca  ggccaagat  cgcaacctg  agacgcagc  caaggtgct  540
gagctgacg  cggagaacg  gcggctgca  aagaaggtg  agcagctgt  gcgagagct  600
agcacgctg  ggaacttgt  caagcagct  cccgagccg  tgctggcct  ggcgggtca  660
tgctagccc  gcgggggtg  cgtgggggc  ccgcggcca  cctgggcac  gtgcgccct  720
ccccgcgcg  tccgtcccc  cgcgcgccc  gggcaccgt  cgtgcaccg  gcgcacctg  780
acctgcacc  aggggacac  gtgggcacc  cgcgcacgc  cctgcaccg  gcaccgggt  840
tcgggactt  atgcaatcc  gatcaaacg  ggctgagcg  gtgtggaca  gggactgac  900
caacacacg  gtaactgtc  gccgggccc  gagtaatca  ttaaagatg  tcctgcggg  960
ttgttgctg  tgatgtttt  gtttttgtt  tttgttttt  gtttttttt  tggtcttat  1020
atttttttg  attatataa  aaagttcta  ttctatgag  aaagaggcg  atgtatatt  1080
tgagaacct  ttccgtttc  agcattaaa  tgaagacat  ttaataaac  tttttggag  1140
atgtttaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaa  1194



<210> 9773
<211> 297
<212> PRT
<213> Rattus norvegicus
<308> P21272
<400> 9773

Met His Arg Leu Leu Ala Trp Asp Ala Ala Cys Leu Pro Pro Pro Pro 
  1               5                  10                  15
Ala Ala Phe Arg Pro Met Glu Val Ala Asn Phe Tyr Tyr Glu Pro Asp 
             20                  25                  30
Cys Leu Ala Tyr Gly Ala Lys Ala Ala Arg Ala Ala Pro Arg Ala Pro 
         35                  40                  45
Ala Ala Glu Pro Ala Ile Gly Glu His Glu Arg Ala Ile Asp Phe Ser 
     50                  55                  60
Pro Tyr Leu Glu Pro Leu Ala Pro Ala Ala Ala Asp Phe Ala Ala Pro 
 65                  70                  75                  80
Ala Pro Ala His His Asp Phe Leu Ser Asp Leu Phe Ala Asp Asp Tyr 
                 85                  90                  95
Gly Ala Lys Pro Ser Lys Lys Pro Ser Asp Tyr Gly Tyr Val Ser Leu 
             100                105                110
Gly Arg Ala Gly Ala Lys Ala Ala Pro Pro Ala Cys Phe Pro Pro Pro 
         115                120                125
Pro Pro Ala Ala Leu Lys Ala Glu Pro Gly Phe Glu Pro Ala Asp Cys 
     130                135                140
Lys Arg Ala Asp Asp Ala Pro Ala Met Ala Ala Gly Phe Pro Phe Ala 
 145                150                155                160
Leu Arg Ala Tyr Leu Gly Tyr Gln Ala Thr Pro Ser Gly Ser Ser Gly 
                 165                170                175
Ser Leu Ser Thr Ser Ser Ser Ser Ser Pro Pro Gly Thr Pro Ser Pro 
             180                185                190
Ala Asp Ala Lys Ala Ala Pro Ala Ala Cys Phe Ala Gly Pro Pro Ala 
         195                200                205
Ala Pro Ala Lys Ala Lys Ala Lys Lys Ala Val Asp Lys Leu Ser Asp 
     210                215                220
Glu Tyr Lys Met Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser 
 225                230                235                240
Arg Asp Lys Ala Lys Met Arg Asn Leu Glu Thr Gln His Lys Val Leu 
                 245                250                255
Glu Leu Thr Ala Glu Asn Glu Arg Leu Gln Lys Lys Val Glu Gln Leu 
             260                265                270
Ser Arg Glu Leu Ser Thr Leu Arg Asn Leu Phe Lys Gln Leu Pro Glu 
         275                280                285
Pro Leu Leu Ala Ser Ala Gly His Cys 
     290                295



<210> 9774
<211> 1038
<212> DNA
<213> Homo sapiens
<308> NM_005194
<400> 9774

atgcaacgc  tggtggcct  ggacccagc  tgtctcccc  tgccgccgc  gccgcctgc  60
tttaaatcc  tggaagtgg  caacttcta  tacgaggcg  actgcttgg  tgctgcgta  120
ggcggcaag  cggcccccg  ggcgccccc  gcggccaga  ccgggccgc  cccccccgc  180
ggcgagctg  gcagcatcg  cgaccacga  cgcgccatc  acttcagcc  gtacctgga  240
ccgctgggc  cgccgcagg  cccggcgcc  gccacggcc  cggacacct  cgaggcggc  300
ccgcccgcg  ccgcccccg  gcccgcctc  tccgggcag  accacgact  cctctccga  360
ctcttctcc  acgactacg  gggcaagaa  tgcaagaag  cggccgagt  cggctacgt  420
agcctgggg  gcctggggg  tgccaaggg  gcgctgcac  ccggctgct  cgcgcccct  480
cacccaccg  ccccgccgc  gccgccgcc  gccgagctc  aggcggagc  gggcttcga  540
cccgcggac  gcaagcgga  ggaggaggc  ggggcgccg  gcggcggcg  aggcatggc  600
gcgggcttc  cgtacgcgc  gcgcgctta  ctcggctac  aggcggtgc  gagcggcag  660
agcgggagc  tctccacgt  ctcctcgtc  agcccgccc  gcacgccga  ccccgctga  720
gccaaggcc  ccccgaccg  ctgctacgc  ggggccggg  cggcgccct  gcaggtcaa  780
agcaaggcc  agaagaccg  ggacaagca  agcgacgag  acaagatcc  gcgcgagcg  840
aacaacatc  ccgtgcgca  gagccgcga  aaggccaag  tgcgcaacc  ggagacgca  900
cacaaggtc  tggagctca  ggccgagaa  gagcggctg  agaagaagg  ggagcagct  960
tcgcgcgag  tcagcaccc  gcggaactt  ttcaagcag  tgcccgagc  cctgctcgc  1020
tcctccggc  actgctag  1038



<210> 9775
<211> 345
<212> PRT
<213> Homo sapiens
<308> NP_005185
<400> 9775

Met Gln Arg Leu Val Ala Trp Asp Pro Ala Cys Leu Pro Leu Pro Pro 
  1               5                  10                  15
Pro Pro Pro Ala Phe Lys Ser Met Glu Val Ala Asn Phe Tyr Tyr Glu 
             20                  25                  30
Ala Asp Cys Leu Ala Ala Ala Tyr Gly Gly Lys Ala Ala Pro Ala Ala 
         35                  40                  45
Pro Pro Ala Ala Arg Pro Gly Pro Arg Pro Pro Ala Gly Glu Leu Gly 
     50                  55                  60
Ser Ile Gly Asp His Glu Arg Ala Ile Asp Phe Ser Pro Tyr Leu Glu 
 65                  70                  75                  80
Pro Leu Gly Ala Pro Gln Ala Pro Ala Pro Ala Thr Ala Thr Asp Thr 
                 85                  90                  95
Phe Glu Ala Ala Pro Pro Ala Pro Ala Pro Ala Pro Ala Ser Ser Gly 
             100                105                110
Gln His His Asp Phe Leu Ser Asp Leu Phe Ser Asp Asp Tyr Gly Gly 
         115                120                125
Lys Asn Cys Lys Lys Pro Ala Glu Tyr Gly Tyr Val Ser Leu Gly Arg 
     130                135                140
Leu Gly Ala Ala Lys Gly Ala Leu His Pro Gly Cys Phe Ala Pro Leu 
 145                150                155                160
His Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Glu Leu Lys Ala Glu 
                 165                170                175
Pro Gly Phe Glu Pro Ala Asp Cys Lys Arg Lys Glu Glu Ala Gly Ala 
             180                185                190
Pro Gly Gly Gly Ala Gly Met Ala Ala Gly Phe Pro Tyr Ala Leu Arg 
         195                200                205
Ala Tyr Leu Gly Tyr Gln Ala Val Pro Ser Gly Ser Ser Gly Ser Leu 
     210                215                220
Ser Thr Ser Ser Ser Ser Ser Pro Pro Gly Thr Pro Ser Pro Ala Asp 
 225                230                235                240
Ala Lys Ala Pro Pro Thr Ala Cys Tyr Ala Gly Ala Gly Pro Ala Pro 
                 245                250                255
Ser Gln Val Lys Ser Lys Ala Lys Lys Thr Val Asp Lys His Ser Asp 
             260                265                270
Glu Tyr Lys Ile Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser 
         275                280                285
Arg Asp Lys Ala Lys Met Arg Asn Leu Glu Thr Gln His Lys Val Leu 
     290                295                300
Glu Leu Thr Ala Glu Asn Glu Arg Leu Gln Lys Lys Val Glu Gln Leu 
 305                310                315                320
Ser Arg Glu Leu Ser Thr Leu Arg Asn Leu Phe Lys Gln Leu Pro Glu 
                 325                330                335
Pro Leu Leu Ala Ser Ser Gly His Cys 
             340                345



<210> 9776
<211> 1542
<212> DNA
<213> Rattus norvegicus
<308> X61295
<400> 9776

catccacca  gatcaagta  gcttcatcc  aggcatgca  ggatggttt  atatacgga  60
aaccatcaa  gtgatccat  atataaaca  actgaaaga  cagaaccac  tgatcattt  120
attagatgc  gagaaagca  ttgacaaaa  tcaacaccc  ttcatgata  aagtcctgg  180
aaaaatagg  attcaaggc  catacctaa  catagtaaa  gccatatac  gcaaaccag  240
tgctaacat  aaactaaat  gagagaaac  tgaagcaat  ccactaaaa  cagggacta  300
acaaggctg  ccacgctct  cctacttat  caatatagt  cttgaagtt  tagccagag  360
aatcagaca  caaaaggag  tcaaaggga  acagatcgg  aaagaagag  tcaaaatat  420
actatttgc  gatgatatg  tagtatatt  aagtgatcc  aaaagttcc  ccagagaac  480
actaaagct  ataaacaac  tcagcaaag  ggctgggta  aaaattaac  caaataaat  540
agttgcctt  ctctataca  aagagaaac  agccgagaa  gaaattagg  aaacgacac  600
cttcataat  gacccaaat  atataaagt  cctcggtgt  actttaacc  agcaagtaa  660
agatctgta  aataagaac  tcaagacac  gaagaaaga  attgaagaa  acctcagaa  720
atggaaaga  ctcccatgc  catggattg  caggattaa  atagtaaaa  tggccattt  780
accaaaagc  atctacaga  tcaatgcaa  ccccatcaa  ataccaatc  aattcttca  840
agagttaga  agaacaatt  gcaaattca  ctggaataa  aaaaaaccc  ggatacgta  900
agctatcct  aacaataaa  ggacttcag  gggaatcac  atccctgaa  tcaagcagt  960
ttacagagc  atagtgata  aaactgcat  gtattggta  agagacaga  agatagacc  1020
atggaatag  attgaagac  cagaaatga  cccacacac  tatggtcac  tgatttttg  1080
caaaggagc  aaagccatc  aatggaaaa  agatagcat  ttcagcaaa  ggtgctggt  1140
caactggag  gcaacatgt  gaagaatgc  gatcgatcc  tgcttatca  cctgtacaa  1200
gcttaagtc  aagtggatc  aggacctcc  catcaaacc  gacacactc  aactaatag  1260
agaaaaact  gggaagcat  tggaacaca  gggcactgg  aaaaatttc  tgaacaaaa  1320
accaatggc  tatgctcta  gatcaagaa  tgacaaatg  gatctcata  aactgcaaa  1380
cttctgtaa  gcaaaggac  ctgtggtta  gacaaaacg  caaccaaca  attgggaaa  1440
gatctttac  aaccctaca  cagatagag  ccttatatc  aaaatatac  aagaactca  1500
gaagttaga  cgcagggaa  caaataacc  tattaaaaa  tg  1542



<210> 9777
<211> 513
<212> PRT
<213> Rattus norvegicus
<308> CAA43593
<400> 9777

Ile His His Asp Gln Val Gly Phe Ile Pro Gly Met Gln Gly Trp Phe 
  1               5                  10                  15
Asn Ile Arg Lys Thr Ile Asn Val Ile His Tyr Ile Asn Lys Leu Lys 
             20                  25                  30
Glu Gln Asn His Met Ile Ile Ser Leu Asp Ala Glu Lys Ala Phe Asp 
         35                  40                  45
Lys Ile Gln His Pro Phe Met Ile Lys Val Leu Glu Lys Ile Gly Ile 
     50                  55                  60
Gln Gly Pro Tyr Leu Asn Ile Val Lys Ala Ile Tyr Ser Lys Pro Val 
 65                  70                  75                  80
Ala Asn Ile Lys Leu Asn Gly Glu Lys Leu Glu Ala Ile Pro Leu Lys 
                 85                  90                  95
Ser Gly Thr Arg Gln Gly Cys Pro Arg Ser Pro Tyr Leu Phe Asn Ile 
             100                105                110
Val Leu Glu Val Leu Ala Arg Ala Ile Arg Gln Gln Lys Glu Ile Lys 
         115                120                125
Gly Ile Gln Ile Gly Lys Glu Glu Val Lys Ile Ser Leu Phe Ala Asp 
     130                135                140
Asp Met Ile Val Tyr Leu Ser Asp Pro Lys Ser Ser Thr Arg Glu Leu 
 145                150                155                160
Leu Lys Leu Ile Asn Asn Phe Ser Lys Val Ala Gly Tyr Lys Ile Asn 
                 165                170                175
Ser Asn Lys Ser Val Ala Phe Leu Tyr Thr Lys Glu Lys Gln Ala Glu 
             180                185                190
Lys Glu Ile Arg Glu Thr Thr Pro Phe Ile Ile Asp Pro Asn Asn Ile 
         195                200                205
Lys Tyr Leu Gly Val Thr Leu Thr Lys Gln Val Lys Asp Leu Tyr Asn 
     210                215                220
Lys Asn Phe Lys Thr Leu Lys Lys Glu Ile Glu Glu Asp Leu Arg Arg 
 225                230                235                240
Trp Lys Asp Leu Pro Cys Ser Trp Ile Gly Arg Ile Asn Ile Val Lys 
                 245                250                255
Met Ala Ile Leu Pro Lys Ala Ile Tyr Arg Phe Asn Ala Ile Pro Ile 
             260                265                270
Lys Ile Pro Ile Gln Phe Phe Lys Glu Leu Asp Arg Thr Ile Cys Lys 
         275                280                285
Phe Ile Trp Asn Asn Lys Lys Pro Arg Ile Arg Lys Ala Ile Leu Asn 
     290                295                300
Asn Lys Arg Thr Ser Gly Gly Ile Thr Ile Pro Glu Leu Lys Gln Tyr 
 305                310                315                320
Tyr Arg Ala Ile Val Ile Lys Thr Ala Trp Tyr Trp Tyr Arg Asp Arg 
                 325                330                335
Gln Ile Asp Gln Trp Asn Arg Ile Glu Asp Pro Glu Met Asn Pro His 
             340                345                350
Thr Tyr Gly His Leu Ile Phe Asp Lys Gly Ala Lys Ala Ile Gln Trp 
         355                360                365
Lys Lys Asp Ser Ile Phe Ser Lys Trp Cys Trp Phe Asn Trp Arg Ala 
     370                375                380
Thr Cys Arg Arg Met Gln Ile Asp Pro Cys Leu Ser Pro Cys Thr Lys 
 385                390                395                400
Leu Lys Ser Lys Trp Ile Lys Asp Leu His Ile Lys Pro Asp Thr Leu 
                 405                410                415
Lys Leu Ile Glu Glu Lys Leu Gly Lys His Leu Glu His Met Gly Thr 
             420                425                430
Gly Lys Asn Phe Leu Asn Lys Thr Pro Met Ala Tyr Ala Leu Arg Ser 
         435                440                445
Arg Ile Asp Lys Trp Asp Leu Ile Lys Leu Gln Ser Phe Cys Lys Ala 
     450                455                460
Lys Asp Thr Val Val Arg Thr Lys Arg Gln Pro Thr Asp Trp Glu Lys 
 465                470                475                480
Ile Phe Thr Asn Pro Thr Thr Asp Arg Gly Leu Ile Ser Lys Ile Tyr 
                 485                490                495
Lys Glu Leu Lys Lys Leu Asp Arg Arg Glu Thr Asn Asn Pro Ile Lys 
             500                505                510
Lys 
         515



<210> 9778
<211> 5979
<212> DNA
<213> Homo sapiens
<308> U93574
<400> 9778

gtctacagc  cccagcgtg  gcgacgcag  agacgggtg  tttctgcat  tccgtctga  60
gtaccgggt  catctcact  gggagtgcc  gacagtggg  gcaggccag  gtgtgtgtg  120
accgtgcgc  agccgaagc  gggcgaggc  ttgcctcac  tgggaagcg  aaggggtca  180
ggagttccc  ttccgagtc  aagaaaggg  tgacggacg  acctggaaa  tcgggtcac  240
cccacccga  tattgcgct  ttcagaccg  cttaagaaa  ggcgcacca  gagactata  300
cccacacct  gctcagagg  tcctacgcc  acggagtct  gctgattgc  agcacagca  360
tctgagatc  aactgcaag  cggcaacga  gctggggga  gggcgcccg  cattgccca  420
gcttgctta  gtaaacaaa  cagccggga  gctcgaact  ggtggagcc  accacagct  480
aaggaggcc  gcctgcctc  gtaggctcc  cctctgggg  cagggcaca  acacacaaa  540
agacagcag  aacctctgc  cacttaagt  tccctgtct  acagctttg  agagagcag  600
ggttctccc  gcacgcagc  ggagatctg  gaacgggca  actgcctcc  caagtgggt  660
cctgacccc  gacccccga  cagcctaac  gggaggcac  ccccagcag  ggcacactg  720
cacctcaca  ggcagggta  tccaacaga  ctgcagctg  gggtcctgt  tgttagaag  780
aaaactaac  accagaaag  acatctaca  cgaaaaccc  tctgtacat  accatcatc  840
aagaccaaa  gtagataaa  ccacaaaga  ggggaaaaa  cagaacaga  aaactggaa  900
ctctaaaac  cagagcgcc  ctcctcctc  aaaggaacg  agttcctca  cagcaacag  960
acaaagctg  atggagaat  attttgacg  gctgagaga  gaaggcttc  gacgatcaa  1020
ttactctga  ctacgggag  acattcaaa  caaaggcaa  gaagttgaa  actttgaaa  1080
aaatttaga  gaatgtata  ctagaatat  caatacaga  aagtgctta  aggagctga  1140
ggagctgaa  atcaaggct  gagaactac  tgaagaatg  agaagcctc  ggagccgat  1200
cgatcaact  gaagaaagg  tatcagcaa  ggaagatga  atgaatgaa  tgaagcgag  1260
agggaagtt  agagaaaaa  gaataaaaa  aaatgagca  agcctccaa  aaatatggg  1320
ctatgtgaa  agaccaaat  tacgtctga  tggtgtacc  gaaagtgat  tggagaatg  1380
aaccaagtt  gaaaacact  tgcaggata  tatccagga  aacttcccc  atctagcaa  1440
gcaggccaa  gttcagatt  aggaaatac  gagaacgcc  caaagatac  cctcgagaa  1500
agcaactcc  agacacata  ttgtcagat  caccaaagt  gaaatgaag  aaaaaatgt  1560
aagggcagc  agagagaaa  gtcgggtta  cctcaaagg  aagcccatc  gactaacag  1620
ggatctctc  gcagaaacc  tacaagcca  aagagagtg  gggccaata  tcaacattc  1680
taaagaaaa  aattttcaa  ccagaattt  atatccagc  aaactaagc  tcataagtg  1740
aggagaaat  aaatacttt  tagacaagc  aatgctgag  gattttgtc  ccaccaggc  1800
tgccctaaa  gagctcctg  aggaagcgc  aaacatgga  aggaacaac  ggtaccagc  1860
actgcaaaa  catgccaaa  tgtaaagac  atcaagact  ggaagaaac  gcatcaact  1920
atgagcaaa  tcaccagct  acatcataa  gacaggatc  aattcacac  taacaatat  1980
aactttaaa  ataaatgga  taaattctg  aattaaaag  cacagactg  caagttgga  2040
aaagagtca  gacccatca  tgtgctgta  tcaggaaac  catctcaca  gcagagaca  2100
acataggct  aaaataaaa  gatggagga  gatctacca  gccaatgga  aacaaaaaa  2160
ggcaggggt  gcaatccta  tctctgata  aacagactt  aaaccaaca  agatcaaaa  2220
agacaaaga  ggccattac  taatggtaa  gggatcaat  caacaagag  agctaacta  2280
cctaaatat  tatgcaccc  atacaggag  acccagatt  ataaagcaa  tcctcagtg  2340
cctacaaag  gacttagac  cccacacat  aataatggg  gactttaac  ccccactgt  2400
aacattaga  agatcaacg  gacagaaag  caacaagga  acccaggaa  tgaactcag  2460
tctgcacca  gcagaccta  tagacatct  cagaactct  caccccaaa  caacagaat  2520
tacattttt  tcagcacca  accacacct  ttccaaaat  gaccacata  ttggaagta  2580
agctctcct  agcaaatgt  aaagaacag  aattataac  aactatctc  cagaccaca  2640
tgcaatcaa  ctagaactc  ggattaaga  tctcactca  agccgctca  ctacatgga  2700
actgaacaa  ctgctcctg  gtgactact  gctacataa  gaaatgaag  cagaaataa  2760
gatgttctt  gaaaccaac  agaacaaag  caccacata  cagaatctc  gggacgcat  2820
caaagcagt  tgtagaggg  aatttatag  actaaatgc  tacaagaga  agcaggaaa  2880
atccaaaat  gacacccta  catcacaat  aaaagaact  gaaaagcaa  agcaaacac  2940
ttcaaaagc  agcagtagg  aagaaataa  taaaatcag  gcagaactg  aggaaatag  3000
gacacaaaa  acccttcaa  aaatcaatg  atccaggat  tggtttttt  aaaggatca  3060
caaaattga  agaccgcta  caagactaa  aaagaaaaa  agagagaag  atcaaatag  3120
cacaataaa  aatgataaa  gggatatca  caccgatcc  acagaaata  aaactacca  3180
cagagaata  tacaaacac  tctacgcaa  taaactaga  aatctagaa  aaatggata  3240
attcctcaa  acatacact  tcccaacac  aaaccagga  gaagttgaa  ctctgaata  3300
accaataac  ggctctgaa  ttgtggcaa  aatcaatag  ttaccaacc  aaaagagtc  3360
aggaccaga  ggattcaca  ccgaattct  ccagaggta  aaggaggag  tggtaccat  3420
ccttctgaa  ctattccaa  caacagaaa  agagggaat  ctccctaac  cattttatg  3480
ggccagcat  attctgata  caaagccgg  cagagacac  accaaaaaa  agaatttta  3540
accaatatc  ttgatgaac  ttgatgcaa  aatcctcaa  aaaatactg  caaaccgaa  3600
ccagcagca  atcaaaaag  ttatccacc  tgatcaagt  ggcttcatc  ctgggatgc  3660
aggctggtt  aatatacgc  aatcaataa  tgtaatcca  catataaac  gagccaaag  3720
caaaaacca  atgattatc  caatagatg  agaaaaagc  tttgacaaa  ttcaacaac  3780
cttcatgct  aaaactctc  ataaattag  tattgatgg  acgtatttc  aaataataa  3840
agctatcta  gacaaaccc  cagccaata  catactgaa  gggcaaaaa  tggaagcat  3900
ccctttgaa  actggcaca  gacagggat  ccctctctc  ccgctccta  tcaacatag  3960
gttggaagt  ctggccagg  caatcaggc  ggagaagga  ataaagggt  ttcaattag  4020
aaaagagga  gtcaaattg  ccctgtttg  agacgacat  attgtttat  tagaaaacc  4080
catcgtctc  gcccaaaat  tccttaagc  gataagcaa  ttcagcaaa  tctcaggat  4140
caaaatcaa  gtacaaaaa  cacaagcat  cttatacac  aacaacaga  aaacagaga  4200
ccaaatcat  agtgaactc  cattcacaa  tgcttcaaa  agaataaaa  acctaggaa  4260
ccaacttac  agggatgtg  aggacctct  caaggagaa  tacaaacca  tgctcaagg  4320
aataaaaga  gacacaaac  aatggaaga  cattccatg  tcatgggta  gaagaatca  4380
tatcgtgaa  atggccata  tgcccaagg  aatttacag  ttcaatgcc  tccccatca  4440
gctaccaat  actttcttc  cagaattgg  aaaaactac  ttaaagttc  tatggaacc  4500
aaaaagagc  cgcattgcc  aggcaatcc  aagccaaaa  aacaaagct  gaggcatca  4560
actacctga  ttcaaacta  actacaagg  tacagtaac  aaaacagca  ggtactggt  4620
ccaaaacag  gatatagat  aatggaaca  aacagagcc  tcagaaata  tgccacata  4680
ctacaacta  ctgatcttt  acaaacctg  gaaaaacaa  caatgggga  aggattccc  4740
atttaataa  tggtgctgg  aaaactggc  agccatatg  agaaagctg  aactggatc  4800
cttccttac  ccttataca  aaatcaatt  aagatggat  aaagattta  acgttagac  4860
taaaaccat  aaaacccta  aagaaaacc  aggcattac  attcaggac  taggcgtgg  4920
caaggactt  atgtccaaa  caccaaaag  aatggcaac  aaagccaaa  ttgacaaat  4980
ggatctaat  aaactaaag  gcttctgca  agcaaaaga  actaccatc  gagcgaaca  5040
gcaacctac  acatgggag  aaattttcg  aacctactc  tctgacaaa  ggctaatat  5100
cagaatcta  aatgaactc  aacaaattt  caagaaaaa  acaaacaac  ccatcaaaa  5160
gtgggcaaa  gacatgaac  gacacttct  aaaagaaga  atttatgca  ccaaaaaac  5220
catgaagaa  tgctcatca  cactggcca  cagagagat  caaatcaaa  ccactatga  5280
atgtcattt  acaccagtt  gaatggcaa  cattaaaaa  tcaggaaac  acaggtgct  5340
gagaggatg  ggagaaata  gaacacttt  acactgttg  tgggactgt  aactagttc  5400
accattgtg  aagtcagtg  ggcgattcc  cagggatct  gaactagaa  taccatttg  5460
cccagccat  ccattactg  gtatatacc  aaaggacta  aaatcatgc  gctataaag  5520
cacatgcac  cgtatgttt  ttgcggcac  attcacaat  gcaaagact  ggaaccaac  5580
caaatgtcc  acaatgata  actggatta  gaaaatgtg  cacatatac  ccatggaat  5640
ctatgcagc  ataaaaaat  atgagttca  gtcctttgt  gggacatgg  tgaaattgg  5700
aaccatcat  ctcagtaaa  tatcgcaag  acaaaaaac  aaacaccgc  tattctcac  5760
cataggtgg  aattgaaca  tgagatcac  tggacacag  aaggggaat  tcacactct  5820
gggattgtg  tggggtcgg  ggagggggg  gggatagca  tgggagata  acctaatgc  5880
agatgacac  ttagtgggt  cagcacacc  gcatggcac  tgtatacat  tgtaactaa  5940
ctgcacaat  tgcacatgt  ccctaaaac  tagagtata  5979



<210> 9779
<211> 1275
<212> PRT
<213> Homo sapiens
<308> AAC51279
<400> 9779

Met Thr Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Asn Ile Asn 
  1               5                  10                  15
Gly Leu Asn Ser Ala Ile Lys Arg His Arg Leu Ala Ser Trp Ile Lys 
             20                  25                  30
Ser Gln Asp Pro Ser Val Cys Cys Ile Gln Glu Thr His Leu Thr Cys 
         35                  40                  45
Arg Asp Thr His Arg Leu Lys Ile Lys Gly Trp Arg Lys Ile Tyr Gln 
     50                  55                  60
Ala Asn Gly Lys Gln Lys Lys Ala Gly Val Ala Ile Leu Val Ser Asp 
 65                  70                  75                  80
Lys Thr Asp Phe Lys Pro Thr Lys Ile Lys Arg Asp Lys Glu Gly His 
                 85                  90                  95
Tyr Ile Met Val Lys Gly Ser Ile Gln Gln Glu Glu Leu Thr Ile Leu 
             100                105                110
Asn Ile Tyr Ala Pro Asn Thr Gly Ala Pro Arg Phe Ile Lys Gln Val 
         115                120                125
Leu Ser Asp Leu Gln Arg Asp Leu Asp Ser His Thr Leu Ile Met Gly 
     130                135                140
Asp Phe Asn Thr Pro Leu Ser Thr Leu Asp Arg Ser Thr Arg Gln Lys 
 145                150                155                160
Val Asn Lys Asp Thr Gln Glu Leu Asn Ser Ala Leu His Gln Ala Asp 
                 165                170                175
Leu Ile Asp Ile Tyr Arg Thr Leu His Pro Lys Ser Thr Glu Tyr Thr 
             180                185                190
Phe Phe Ser Ala Pro His His Thr Tyr Ser Lys Ile Asp His Ile Val 
         195                200                205
Gly Ser Lys Ala Leu Leu Ser Lys Cys Lys Arg Thr Glu Ile Ile Thr 
     210                215                220
Asn Tyr Leu Ser Asp His Ser Ala Ile Lys Leu Glu Leu Arg Ile Lys 
 225                230                235                240
Asn Leu Thr Gln Ser Arg Ser Thr Thr Trp Lys Leu Asn Asn Leu Leu 
                 245                250                255
Leu Ser Asp Tyr Trp Leu His Asn Glu Met Lys Ala Glu Ile Lys Met 
             260                265                270
Phe Phe Glu Thr Asn Glu Asn Lys Asp Thr Thr Tyr Gln Asn Leu Trp 
         275                280                285
Asp Ala Phe Lys Ala Val Cys Arg Gly Lys Phe Ile Ala Leu Asn Ala 
     290                295                300
Tyr Lys Arg Lys Gln Glu Arg Ser Lys Ile Asp Thr Leu Thr Ser Gln 
 305                310                315                320
Leu Lys Glu Leu Glu Lys Gln Glu Gln Thr His Ser Lys Ala Ser Ser 
                 325                330                335
Arg Gln Glu Ile Thr Lys Ile Arg Ala Glu Leu Lys Glu Ile Glu Thr 
             340                345                350
Gln Lys Thr Leu Gln Lys Ile Asn Glu Ser Arg Ile Trp Phe Phe Glu 
         355                360                365
Arg Ile Asn Lys Ile Asp Arg Pro Leu Ala Arg Leu Ile Lys Lys Lys 
     370                375                380
Arg Glu Lys Asn Gln Ile Asp Thr Ile Lys Asn Asp Lys Gly Asp Ile 
 385                390                395                400
Thr Thr Asp Pro Thr Glu Ile Gln Thr Thr Ile Arg Glu Tyr Tyr Lys 
                 405                410                415
His Leu Tyr Ala Asn Lys Leu Glu Asn Leu Glu Glu Met Asp Thr Phe 
             420                425                430
Leu Asn Thr Tyr Thr Leu Pro Thr Leu Asn Gln Glu Glu Val Glu Ser 
         435                440                445
Leu Asn Arg Pro Ile Thr Gly Ser Glu Ile Val Ala Ile Ile Asn Ser 
     450                455                460
Leu Pro Thr Lys Lys Ser Pro Gly Pro Asp Gly Phe Thr Ala Glu Phe 
 465                470                475                480
Tyr Gln Arg Tyr Lys Glu Glu Leu Val Pro Phe Leu Leu Lys Leu Phe 
                 485                490                495
Gln Ser Thr Glu Lys Glu Gly Ile Leu Pro Asn Ser Phe Tyr Glu Ala 
             500                505                510
Ser Ile Ile Leu Ile Pro Lys Pro Gly Arg Asp Thr Thr Lys Lys Glu 
         515                520                525
Asn Phe Arg Pro Ile Ser Leu Met Asn Ile Asp Ala Lys Ile Leu Asn 
     530                535                540
Lys Ile Leu Ala Asn Arg Ile Gln Gln His Ile Lys Lys Leu Ile His 
 545                550                555                560
His Asp Gln Val Gly Phe Ile Pro Gly Met Gln Gly Trp Phe Asn Ile 
                 565                570                575
Arg Lys Ser Ile Asn Val Ile Gln His Ile Asn Arg Ala Lys Asp Lys 
             580                585                590
Asn His Met Ile Ile Ser Ile Asp Ala Glu Lys Ala Phe Asp Lys Ile 
         595                600                605
Gln Gln Pro Phe Met Leu Lys Thr Leu Asn Lys Leu Gly Ile Asp Gly 
     610                615                620
Thr Tyr Phe Lys Ile Ile Arg Ala Ile Tyr Asp Lys Pro Thr Ala Asn 
 625                630                635                640
Ile Ile Leu Asn Gly Gln Lys Leu Glu Ala Phe Pro Leu Lys Thr Gly 
                 645                650                655
Thr Arg Gln Gly Cys Pro Leu Ser Pro Leu Leu Phe Asn Ile Val Leu 
             660                665                670
Glu Val Leu Ala Arg Ala Ile Arg Gln Glu Lys Glu Ile Lys Gly Ile 
         675                680                685
Gln Leu Gly Lys Glu Glu Val Lys Leu Ser Leu Phe Ala Asp Asp Met 
     690                695                700
Ile Val Tyr Leu Glu Asn Pro Ile Val Ser Ala Gln Asn Leu Leu Lys 
 705                710                715                720
Leu Ile Ser Asn Phe Ser Lys Val Ser Gly Tyr Lys Ile Asn Val Gln 
                 725                730                735
Lys Ser Gln Ala Phe Leu Tyr Thr Asn Asn Arg Gln Thr Glu Ser Gln 
             740                745                750
Ile Met Ser Glu Leu Pro Phe Thr Ile Ala Ser Lys Arg Ile Lys Tyr 
         755                760                765
Leu Gly Ile Gln Leu Thr Arg Asp Val Lys Asp Leu Phe Lys Glu Asn 
     770                775                780
Tyr Lys Pro Leu Leu Lys Glu Ile Lys Glu Asp Thr Asn Lys Trp Lys 
 785                790                795                800
Asn Ile Pro Cys Ser Trp Val Gly Arg Ile Asn Ile Val Lys Met Ala 
                 805                810                815
Ile Leu Pro Lys Val Ile Tyr Arg Phe Asn Ala Ile Pro Ile Lys Leu 
             820                825                830
Pro Met Thr Phe Phe Thr Glu Leu Glu Lys Thr Thr Leu Lys Phe Ile 
         835                840                845
Trp Asn Gln Lys Arg Ala Arg Ile Ala Lys Ala Ile Leu Ser Gln Lys 
     850                855                860
Asn Lys Ala Gly Gly Ile Thr Leu Pro Asp Phe Lys Leu Tyr Tyr Lys 
 865                870                875                880
Ala Thr Val Thr Lys Thr Ala Trp Tyr Trp Tyr Gln Asn Arg Asp Ile 
                 885                890                895
Asp Gln Trp Asn Arg Thr Glu Pro Ser Glu Ile Met Pro His Ile Tyr 
             900                905                910
Asn Tyr Leu Ile Phe Asp Lys Pro Glu Lys Asn Lys Gln Trp Gly Lys 
         915                920                925
Asp Ser Leu Phe Asn Lys Trp Cys Trp Glu Asn Trp Leu Ala Ile Cys 
     930                935                940
Arg Lys Leu Lys Leu Asp Pro Phe Leu Thr Pro Tyr Thr Lys Ile Asn 
 945                950                955                960
Ser Arg Trp Ile Lys Asp Leu Asn Val Arg Pro Lys Thr Ile Lys Thr 
                 965                970                975
Leu Glu Glu Asn Leu Gly Ile Thr Ile Gln Asp Ile Gly Val Gly Lys 
             980                985                990
Asp Phe Met Ser Lys Thr Pro Lys Ala Met Ala Thr Lys Ala Lys Ile 
         995                1000                1005
Asp Lys Trp Asp Leu Ile Lys Leu Lys Ser Phe Cys Thr Ala Lys Glu 
     1010                1015                1020
Thr Thr Ile Arg Ala Asn Arg Gln Pro Thr Thr Trp Glu Lys Ile Phe 
 1025                1030                1035                1040
Ala Thr Tyr Ser Ser Asp Lys Gly Leu Ile Ser Arg Ile Tyr Asn Glu 
                 1045                1050                1055
Leu Lys Gln Ile Tyr Lys Lys Lys Thr Asn Asn Pro Ile Lys Lys Trp 
             1060                1065                1070
Ala Lys Asp Met Asn Arg His Phe Ser Lys Glu Asp Ile Tyr Ala Ala 
         1075                1080                1085
Lys Lys His Met Lys Lys Cys Ser Ser Ser Leu Ala Ile Arg Glu Met 
     1090                1095                1100
Gln Ile Lys Thr Thr Met Arg Cys His Phe Thr Pro Val Arg Met Ala 
 1105                1110                1115                1120
Ile Ile Lys Lys Ser Gly Asn Asn Arg Cys Trp Arg Gly Cys Gly Glu 
                 1125                1130                1135
Ile Gly Thr Leu Leu His Cys Trp Trp Asp Cys Lys Leu Val Gln Pro 
             1140                1145                1150
Leu Trp Lys Ser Val Trp Arg Phe Leu Arg Asp Leu Glu Leu Glu Ile 
         1155                1160                1165
Pro Phe Asp Pro Ala Ile Pro Leu Leu Gly Ile Tyr Pro Lys Asp Tyr 
     1170                1175                1180
Lys Ser Cys Cys Tyr Lys Asp Thr Cys Thr Arg Met Phe Ile Ala Ala 
 1185                1190                1195                1200
Leu Phe Thr Ile Ala Lys Thr Trp Asn Gln Pro Lys Cys Pro Thr Met 
                 1205                1210                1215
Ile Asp Trp Ile Lys Lys Met Trp His Ile Tyr Thr Met Glu Tyr Tyr 
             1220                1225                1230
Ala Ala Ile Lys Asn Asp Glu Phe Met Ser Phe Val Gly Thr Trp Met 
         1235                1240                1245
Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu Ser Gln Glu Gln Lys Thr 
     1250                1255                1260
Lys His Arg Ile Phe Ser Leu Ile Gly Gly Asn 
 1265                1270                1275



<210> 9780
<211> 498
<212> DNA
<213> Rattus norvegicus
<308> X61381
<400> 9780

tgtgtgcga  cgcggtgga  cgctaccat  aaccacact  ctcaagcct  cgtgaacgc  60
gccactggg  gacaacccc  aaactacga  agaatcaag  aagaatatg  ggtgtctga  120
ctgggggct  cccacggat  ggcttctgt  agaactacc  tgatcaaca  gcccagaga  180
gtctctgtg  ctgaccatg  ggtctggtc  ctgttcaat  cgctcttca  gaacttctg  240
tgcctgggc  tcattgcct  tgcctactc  gtgaagtct  gggatcgga  gatggtggg  300
gatatgact  gagcccagg  ctacgcatc  actgccaaa  gcctgaaca  cagctccct  360
gtcctcagc  tcctcatgg  cattatcac  attgttact  tcgtcatca  tgctcttaa  420
gctcctcgt  tccagactt  atagaggat  ctggtttct  atcctgacg  gcttcacgc  480
ctgctggct  cccttttt  498



<210> 9781
<211> 137
<212> PRT
<213> Rattus norvegicus
<308> CAA43655
<400> 9781

Met Asn His Thr Ser Gln Ala Phe Val Asn Ala Ala Thr Gly Gly Gln 
  1               5                  10                  15
Pro Pro Asn Tyr Glu Arg Ile Lys Glu Glu Tyr Glu Val Ser Glu Leu 
             20                  25                  30
Gly Ala Pro His Gly Ser Ala Ser Val Arg Thr Thr Val Ile Asn Met 
         35                  40                  45
Pro Arg Glu Val Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn 
     50                  55                  60
Thr Leu Phe Met Asn Phe Cys Cys Leu Gly Phe Ile Ala Tyr Ala Tyr 
 65                  70                  75                  80
Ser Val Lys Ser Arg Asp Arg Lys Met Val Gly Asp Met Thr Gly Ala 
                 85                  90                  95
Gln Ala Tyr Ala Ser Thr Ala Lys Cys Leu Asn Ile Ser Ser Leu Val 
             100                105                110
Leu Ser Ile Leu Met Val Ile Ile Thr Ile Val Thr Val Val Ile Ile 
         115                120                125
Ala Leu Asn Ala Pro Arg Leu Gln Thr 
     130                135



<210> 9782
<211> 637
<212> DNA
<213> Homo sapiens
<308> BC006794
<400> 9782

ggagggctc  ctgagaacc  tcccagtaa  ccgaccgcc  ctggtcttc  ctggacacc  60
tgaatcaca  tgtccaaac  ttcttctct  ctgtcaaca  tggccagcc  cccaactat  120
agatgctca  ggaggagca  gaggtggct  tgctggggg  gccccacaa  cctgctccc  180
cgacgtcca  cgtgatcca  atccgcagc  agacctccg  gcccgacca  gtcgtctgg  240
ccctgttca  caccctctt  atgaacccc  gctgcctgg  cttcatagc  ttcgcctac  300
ccgtgaagt  tagggacag  aagatggtt  gcgacgtga  cggggccca  gcctatgcc  360
ccaccgcca  gtgcctgaa  atctgggcc  tgattctgg  catcctcat  accattctg  420
tcatcgtca  cccagtgct  atcttccag  cctatggat  gatcaggag  catcactga  480
gccaggagc  ctgcccatg  cctgtatcc  acgtactcc  acttccatt  ctcgccctg  540
ccccggagc  gagtcctgt  tcagccctt  atcctcaca  gcttttcta  aatggcatt  600
aataaagtg  acgtgtttc  gaaaaaaaa  aaaaaaa  637



<210> 9783
<211> 133
<212> PRT
<213> Homo sapiens
<308> Q01628
<400> 9783

Met Asn His Thr Val Gln Thr Phe Phe Ser Pro Val Asn Ser Gly Gln 
  1               5                  10                  15
Pro Pro Asn Tyr Glu Met Leu Lys Glu Glu His Glu Val Ala Val Leu 
             20                  25                  30
Gly Ala Pro His Asn Pro Ala Pro Pro Thr Ser Thr Val Ile His Ile 
         35                  40                  45
Arg Ser Glu Thr Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn 
     50                  55                  60
Thr Leu Phe Met Asn Pro Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr 
 65                  70                  75                  80
Ser Val Lys Ser Arg Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala 
                 85                  90                  95
Gln Ala Tyr Ala Ser Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile 
             100                105                110
Leu Gly Ile Leu Met Thr Ile Leu Leu Ile Val Ile Pro Val Leu Ile 
         115                120                125
Phe Gln Ala Tyr Gly 
     130



<210> 9784
<211> 860
<212> DNA
<213> Rattus norvegicus
<308> X61654
<400> 9784

ggctgctga  ccgcggtag  agagcatca  gaagcgtcg  ggagcgcag  cccagcagc  60
atggcggtg  aaggaggaa  gaagtgtgt  aagtttttg  tctacgttc  cctactggc  120
ttttgcgcc  gcgcagtgg  attgattgc  attggcgta  cagttcagg  tgtcttgaa  180
caggccatt  cccacgaga  tactgctgg  tcgctgttg  ctgtggtca  cattgcagt  240
ggtgccttc  tcttcctgg  ggcctttgt  ggctgctgt  gggcctgca  agagaacta  300
tgtctcatg  ttacatttg  catcttcct  tctcttatc  tgctcgtgg  ggtggcggt  360
gccattgct  gctatgtgt  tagagacca  gtgaagtca  agtttagta  gagcttcca  420
aagcagatg  agaattacc  tacagacaa  aaaacggcc  ccattttgg  caaattgca  480
aaggaaaat  aatgctgtg  agcctctaa  tacacagac  gggagcgca  ccccggtat  540
gccaaggac  gggtccccg  ttcttgctg  atcaacatc  ctgtgggct  tggaaacga  600
ttcaaggaa  ccaccatcc  tacccaggg  tgcgtggaa  ctatagcgg  atggctgag  660
aagaacgta  tgctggtgg  tggagcagc  ctgggcatt  cttttgtgg  ggtcctggg  720
attatcttc  cctgctgtc  ggtgaagag  atccggagt  gctacgaag  aatgtaggg  780
gggggcgtg  ctgagctcg  ctgtctttt  atggagtgg  ctctccagg  tttcaatta  840
acggattat  ttttcagacc  860



<210> 9785
<211> 237
<212> PRT
<213> Rattus norvegicus
<308> P28648
<400> 9785

Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val Leu 
  1               5                  10                  15
Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Ile Gly Val 
             20                  25                  30
Ala Val Gln Val Val Leu Lys Gln Ala Ile Thr His Glu Thr Thr Ala 
         35                  40                  45
Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Ala Phe Leu Phe 
     50                  55                  60
Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr Cys 
 65                  70                  75                  80
Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val Glu 
                 85                  90                  95
Val Ala Val Ala Ile Ala Gly Tyr Val Phe Arg Asp Gln Val Lys Ser 
             100                105                110
Glu Phe Ser Lys Ser Phe Gln Lys Gln Met Gln Asn Tyr Leu Thr Asp 
         115                120                125
Asn Lys Thr Ala Thr Ile Leu Asp Lys Leu Gln Lys Glu Asn Lys Cys 
     130                135                140
Cys Gly Ala Ser Asn Tyr Thr Asp Trp Glu Arg Ile Pro Gly Met Ala 
 145                150                155                160
Lys Asp Arg Val Pro Asp Ser Cys Cys Ile Asn Ile Thr Val Gly Cys 
                 165                170                175
Gly Asn Asp Phe Lys Glu Ser Thr Ile His Thr Gln Gly Cys Val Glu 
             180                185                190
Thr Ile Ala Ala Trp Leu Arg Lys Asn Val Leu Leu Val Ala Gly Ala 
         195                200                205
Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Ile Phe Ser Cys 
     210                215                220
Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
 225                230                235



<210> 9786
<211> 826
<212> DNA
<213> Homo sapiens
<308> X07982
<400> 9786

gccttggga  gcccaggcc  ggcagccat  gcggtggaa  gaggaatga  atgtgtgaa  60
ttcttgctc  acgtcctcc  gctggcctt  tgcgcctgt  cagtgggac  gattgccgt  120
ggtgtcggg  cacagcttg  cctgagtca  accataatc  agggggcta  ccctggctc  180
ctgttgcca  tggtcatca  cgcagtggg  gtcttcctc  tcctggtgg  ttttgtggg  240
tgctgcggg  cctgcaagg  gaactattg  cttatgatc  cgtttgcca  ctttctgtc  300
cttatcatg  tggtggagg  ggccgcagc  attgctggc  atgtgttta  agataaggt  360
atgtcagag  ttaataaca  cttccggca  cagatggag  attacccga  aaacaacca  420
actgcttcg  tcctggaca  gatgcaggc  gattttaag  gctgtgggg  tgctaacta  480
acagattgg  agaaaatcc  ttccatgtc  aagaaccga  tccccgact  ctgctgcat  540
aatgttact  tgggctgtg  gattaattt  aacgagaag  cgatccata  ggagggctg  600
gtggagaag  ttgggggct  gctgaggaa  aatgtgctg  tggtagctg  agcagccct  660
ggaattgct  ttgtcgagg  tttgggaat  gtctttgcc  gctgcctcg  gaagagtat  720
agaagtggc  acgaggtga  gtaggggtc  ggtctcctc  gcctcctca  ctgggggag  780
ggaatagta  cctccaggt  tttcaatta  acggattat  ttttca  826



<210> 9787
<211> 237
<212> PRT
<213> Homo sapiens
<308> P08962
<400> 9787

Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val Leu 
  1               5                  10                  15
Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly Val 
             20                  25                  30
Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr Pro 
         35                  40                  45
Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu Phe 
     50                  55                  60
Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr Cys 
 65                  70                  75                  80
Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val Glu 
                 85                  90                  95
Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met Ser 
             100                105                110
Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys Asn 
         115                120                125
Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys Cys 
     130                135                140
Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met Ser 
 145                150                155                160
Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly Cys 
                 165                170                175
Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val Glu 
             180                185                190
Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala Ala 
         195                200                205
Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala Cys 
     210                215                220
Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
 225                230                235



<210> 9788
<211> 2153
<212> DNA
<213> Rattus norvegicus
<308> X62322
<400> 9788

agggagcgc  gaccccgac  caggcagac  atgtggatc  tggtgagct  gctggcctt  60
gtggcaagg  tggtggctg  aacacagtg  ccagatggt  aattctgcc  tgttgcctg  120
tgccttgac  agggaggag  caactacag  tgctgtaac  ctcttctgg  cacatggcc  180
ataataacg  gccgtcgtc  agatggctc  tgccagatc  gtgaccact  tcctgatgg  240
tactcttgt  ttctcactg  gtctgggac  tccagctgc  gcccgttct  tgagggtgt  300
tcttgtgat  atggccagc  ctgctgccc  cggggcttc  actgtagtg  ggatgggaa  360
tcctgctct  agatatcag  tagcctctt  ggtgctgtc  agtgtcctg  tagccagtt  420
gaatgtcct  actccgcca  ctgctgtat  atgattgat  gttcctggg  gtgctgccc  480
atgccccag  cctcttgct  tgaagacag  gtgcattgc  gtccccacg  ggcctcctg  540
gacctggtt  acacgcgat  catttcacc  acgggcacc  accccttac  aaagaaatt  600
cccgcacaa  ggaccaaca  ggcagtggc  ttccctttt  ccgtggtgt  ccctgatgc  660
aagacccag  gccctgatg  ctctacctg  tgtgagcta  ccactggga  gtatggctg  720
tgtccaatg  ccaacgcca  ctgctgttc  gaccacctg  actgctgcc  ccaggacac  780
gtatgtgac  tgatccaga  caagtgcat  tccaaggac  acaccacag  tctcatgac  840
aagctgcct  gatacccag  gaatgaggt  aagtgcgac  tggaggtga  ctgtcctga  900
ggctacacc  gctgccgcc  caacactgg  gcctggggc  gctgtccat  caccaaggc  960
gtgtgttgt  aagaccaca  tcactgctg  ccagccggg  ttcagtgtc  cacagagac  1020
ggaacctgt  aactgggag  ccttcaggt  ccctggatg  aaaaggtca  ggcctccct  1080
agcctgcca  acccacaga  cttgaagaa  gatgtcccc  gtgatgact  cagtagctg  1140
ccttctaac  atacctgct  cagactcag  tctggggac  ggggctgct  tcccatccc  1200
gaggctgtc  gctgcttag  ccaccagca  tgctgccct  agggtttca  atgtatgga  1260
gaggggtac  gtcagaagg  agacagaat  gtggctggc  tggagaaga  gcctgtccg  1320
cagacaact  tgctccaac  tggagatat  ggttgtgac  agcatacca  ctgcccagt  1380
gggcaaaca  gctgcccaa  cctgaaggg  agttgggcc  gctgccagt  gccccatgc  1440
gtgtgctgt  aggaccggc  gcactgttg  ccggctggg  acacctgca  cgtgaaggc  1500
agaacctgt  agaaggatg  aggctctgt  cagccttcc  tggacctga  ctttggctc  1560
aaggttggg  atgtggaat  tggtgccgg  catttctgc  atgataacc  gtcctgttg  1620
aaagacagc  aaggaggct  ggcctgctg  ccctatgta  agggtgtct  ctgtagaga  1680
ggacgtcac  gttgtccca  tggcttcca  tgttcagcc  agggaacca  gtgtttgcg  1740
aagaagacc  ctcgctggg  catactttt  agggatcca  ccccaagac  gctactgtg  1800
ggaagggct  acgactaaa  aactccaca  tcctgggaa  cctgttctg  gggtatcca  1860
cactcaggc  tccctggca  ctcttcctt  agtctcccc  gcctactca  tctgagtca  1920
cccatcacc  tggaaggtg  ggcctcaaa  taagacctt  tcttatgga  agaaggctg  1980
ggcaaaagc  ccgtatcaa  ctgccattt  ttctgattt  tgtggacct  gtggccagg  2040
gctcttctc  atccacagg  gttgtgtga  cttgctttt  tgtgtgtgt  tgtgcgcgc  2100
tgcgagcgt  ttgctccaa  aaagtttgt  cactttcaa  aaaaaaaaa  aaa  2153



<210> 9789
<211> 588
<212> PRT
<213> Rattus norvegicus
<308> P23785
<400> 9789

Met Trp Ile Leu Val Ser Trp Leu Ala Leu Val Ala Arg Leu Val Ala 
  1               5                  10                  15
Gly Thr Gln Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
             20                  25                  30
Asp Gln Gly Gly Ala Asn Tyr Ser Cys Cys Asn Pro Leu Leu Asp Thr 
         35                  40                  45
Trp Pro Ile Ile Thr Ser Arg Arg Leu Asp Gly Ser Cys Gln Ile Arg 
     50                  55                  60
Asp His Cys Pro Asp Gly Tyr Ser Cys Leu Leu Thr Val Ser Gly Thr 
 65                  70                  75                  80
Ser Ser Cys Cys Pro Phe Ser Glu Gly Val Ser Cys Asp Asp Gly Gln 
                 85                  90                  95
His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Lys Ser Cys 
             100                105                110
Ser Gln Ile Ser Asp Ser Leu Leu Gly Ala Val Gln Cys Pro Gly Ser 
         115                120                125
Gln Phe Glu Cys Pro Asp Ser Ala Thr Cys Cys Ile Met Ile Asp Gly 
     130                135                140
Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp Arg 
 145                150                155                160
Val His Cys Cys Pro His Gly Ala Ser Cys Asp Leu Val His Thr Arg 
                 165                170                175
Cys Ile Ser Pro Thr Gly Thr His Pro Leu Leu Lys Lys Phe Pro Ala 
             180                185                190
Gln Arg Thr Asn Arg Ala Val Ala Ser Phe Ser Val Val Cys Pro Asp 
         195                200                205
Ala Lys Thr Gln Cys Pro Asp Asp Ser Thr Cys Cys Glu Leu Pro Thr 
     210                215                220
Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Ile Cys Cys Ser Asp 
 225                230                235                240
His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile Gln Ser 
                 245                250                255
Lys Cys Ile Ser Lys Asp Tyr Thr Thr Asp Leu Met Thr Lys Leu Pro 
             260                265                270
Gly Tyr Pro Val Asn Glu Val Lys Cys Asp Leu Glu Val Ser Cys Pro 
         275                280                285
Asp Gly Tyr Thr Cys Cys Arg Leu Asn Thr Gly Ala Trp Gly Cys Cys 
     290                295                300
Pro Phe Thr Lys Ala Val Cys Cys Glu Asp His Ile His Cys Cys Pro 
 305                310                315                320
Ala Gly Phe Gln Cys His Thr Glu Thr Gly Thr Cys Glu Leu Gly Val 
                 325                330                335
Leu Gln Val Pro Trp Met Lys Lys Val Thr Ala Ser Leu Ser Leu Pro 
             340                345                350
Asp Pro Gln Ile Leu Lys Asn Asp Val Pro Cys Asp Asp Phe Ser Ser 
         355                360                365
Cys Pro Ser Asn Asn Thr Cys Cys Arg Leu Ser Ser Gly Asp Trp Gly 
     370                375                380
Cys Cys Pro Met Pro Glu Ala Val Cys Cys Leu Asp His Gln His Cys 
 385                390                395                400
Cys Pro Gln Gly Phe Lys Cys Met Asp Glu Gly Tyr Cys Gln Lys Gly 
                 405                410                415
Asp Arg Met Val Ala Gly Leu Glu Lys Met Pro Val Arg Gln Thr Thr 
             420                425                430
Leu Leu Gln His Gly Asp Ile Gly Cys Asp Gln His Thr Ser Cys Pro 
         435                440                445
Val Gly Gln Thr Cys Cys Pro Ser Leu Lys Gly Ser Trp Ala Cys Cys 
     450                455                460
Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His Cys Cys Pro 
 465                470                475                480
Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Thr Cys Glu Lys Asp Ala 
                 485                490                495
Gly Ser Val Gln Pro Ser Met Asp Leu Thr Phe Gly Ser Lys Val Gly 
             500                505                510
Asn Val Glu Cys Gly Ala Gly His Phe Cys His Asp Asn Gln Ser Cys 
         515                520                525
Cys Lys Asp Ser Gln Gly Gly Trp Ala Cys Cys Pro Tyr Val Lys Gly 
     530                535                540
Val Cys Cys Arg Asp Gly Arg His Cys Cys Pro Ile Gly Phe His Cys 
 545                550                555                560
Ser Ala Lys Gly Thr Lys Cys Leu Arg Lys Lys Thr Pro Arg Trp Asp 
                 565                570                575
Ile Leu Leu Arg Asp Pro Ala Pro Arg Pro Leu Leu 
             580                585



<210> 9790
<211> 2152
<212> DNA
<213> Homo sapiens
<308> X62320
<400> 9790

gctgctgcc  aaggaccgc  gagtcggac  caggcagac  atgtggacc  tggtgagct  60
ggtggcctt  acagcaggg  tggtggctg  aacgcggtg  ccagatggt  agttctgcc  120
tgtggcctg  tgcctggac  ccggaggag  cagctacag  tgctgccgt  cccttctgg  180
caaatggcc  acaacactg  gcaggcatc  gggtggccc  tgccaggtt  atgcccact  240
ctctgccgg  cactcctgc  tctttaccg  ctcagggac  tccagttgc  gccccttcc  300
agaggccgt  gcatgcggg  atggccatc  ctgctgccc  cggggcttc  actgcagtg  360
agacgggcg  tcctgcttc  aaagatcag  taacaactc  gtgggtgcc  tccagtgcc  420
tgatagtca  ttcgaatgc  cggacttct  cacgtgctg  gttatggtc  atggctcct  480
ggggtgctg  cccatgccc  aggcttcct  ctgtgaaga  agggtgcac  gctgtccgc  540
cggtgcctt  tgcgacctg  ttcacaccc  ctgcatcac  cccacgggc  cccaccccc  600
ggcaaagaa  ctccctgcc  agaggacta  cagggcagt  gccttgtcc  gctcggtca  660
gtgtccgga  gcacggtcc  ggtgccctg  tggttctac  tgctgtgag  tgcccagtg  720
gaagtatgg  tgctgccca  tgcccaacg  cacctgctg  tccgatcac  tgcactgct  780
cccccaaga  actgtgtgt  acctgatcc  gagtaagtg  ctctccaag  agaacgcta  840
cacggacct  ctcactaag  tgcctgcgc  cacagtggg  gatgtgaaa  gtgacatgg  900
ggtgagctg  ccagatggc  atacctgct  ccgtctaca  tcgggggcc  ggggctgct  960
cccttttac  caggctgtg  gctgtgagg  ccacataca  tgctgtccc  cggggttta  1020
gtgtgacac  cagaagggt  cctgtgaac  ggggcccca  caggtgccc  ggatggaga  1080
ggccccagc  cacctcagc  tgccagacc  acaagcctt  aagagagat  tcccctgtg  1140
taatgtcag  agctgtccc  cctccgata  ctgctgcca  ctcacgtct  gggagtggg  1200
ctgctgtcc  atcccagag  ctgtctgct  ctcggacca  cagcactgc  gcccccagg  1260
ctacacgtg  gtagctgag  ggcagtgtc  gcgaggaag  gagatcgtg  ctggactgg  1320
gaagatgcc  gcccgccgg  cttccttat  ccaccccag  gacatcggc  gtgaccagc  1380
caccagctg  ccggtgggg  agacctgct  cccgagcct  ggtgggagc  gggcctgct  1440
ccagttgcc  catgctgtg  gctgcgagg  tcgccagca  tgctgcccg  ctggctaca  1500
ctgcaacgt  aaggctcga  cctgcgaga  ggaagtggt  tctgcccag  ctgccacct  1560
cctggcccg  agccctcac  tgggtgtga  ggacgtgga  tgtggggaa  gacacttct  1620
ccatgataa  cagacctgc  gccgagaca  ccgacaggg  tgggcctgc  gtccctacc  1680
ccagggcgt  tgttgtgct  atcggcgcc  ctgctgtcc  gctggcttc  gctgcgcag  1740
caggggtac  aagtgtttg  gcagggagg  cccgcgctg  gacgcccct  tgagggacc  1800
agccttgag  cagctgctg  gagggacag  actgaagac  ctgcagccc  cgggacccc  1860
ctcggaggg  gccctctgc  caggcctcc  tagcacctc  ccctaacca  attctccct  1920
gaccccatt  tgagctccc  atcaccatg  gaggtgggg  ctcaatcta  ggccttccc  1980
gtcagaagg  ggttgtggc  aaagccaca  tacaagctg  catcccctc  ccgtttcag  2040
ggaccctgt  gccaggtgc  tttccctat  cacaggggt  tttgtgtgt  tgcgcgtgt  2100
cgtttcaat  aagtttgta  actttcaaa  aaaaaaaaa  aaaaaaaaa  aa  2152



<210> 9791
<211> 593
<212> PRT
<213> Homo sapiens
<308> P28799
<400> 9791

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
  1               5                  10                  15
Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
             20                  25                  30
Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
         35                  40                  45
Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
     50                  55                  60
Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
 65                  70                  75                  80
Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                 85                  90                  95
His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
             100                105                110
Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
         115                120                125
Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
     130                135                140
Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
 145                150                155                160
Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
                 165                170                175
Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro 
             180                185                190
Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys 
         195                200                205
Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu 
     210                215                220
Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys 
 225                230                235                240
Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile 
                 245                250                255
Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr 
             260                265                270
Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val 
         275                280                285
Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp 
     290                295                300
Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His 
 305                310                315                320
Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                 325                330                335
Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
             340                345                350
Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
         355                360                365
Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly 
     370                375                380
Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His 
 385                390                395                400
Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys 
                 405                410                415
Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg 
             420                425                430
Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr 
         435                440                445
Ser Cys Pro Val Gly Gly Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp 
     450                455                460
Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His 
 465                470                475                480
Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu 
                 485                490                495
Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro 
             500                505                510
His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His 
         515                520                525
Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys 
     530                535                540
Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro 
 545                550                555                560
Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu 
                 565                570                575
Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu 
             580                585                590
Leu 
         595



<210> 9792
<211> 2153
<212> DNA
<213> Rattus norvegicus
<308> X62322
<400> 9792

agggagcgc  gaccccgac  caggcagac  atgtggatc  tggtgagct  gctggcctt  60
gtggcaagg  tggtggctg  aacacagtg  ccagatggt  aattctgcc  tgttgcctg  120
tgccttgac  agggaggag  caactacag  tgctgtaac  ctcttctgg  cacatggcc  180
ataataacg  gccgtcgtc  agatggctc  tgccagatc  gtgaccact  tcctgatgg  240
tactcttgt  ttctcactg  gtctgggac  tccagctgc  gcccgttct  tgagggtgt  300
tcttgtgat  atggccagc  ctgctgccc  cggggcttc  actgtagtg  ggatgggaa  360
tcctgctct  agatatcag  tagcctctt  ggtgctgtc  agtgtcctg  tagccagtt  420
gaatgtcct  actccgcca  ctgctgtat  atgattgat  gttcctggg  gtgctgccc  480
atgccccag  cctcttgct  tgaagacag  gtgcattgc  gtccccacg  ggcctcctg  540
gacctggtt  acacgcgat  catttcacc  acgggcacc  accccttac  aaagaaatt  600
cccgcacaa  ggaccaaca  ggcagtggc  ttccctttt  ccgtggtgt  ccctgatgc  660
aagacccag  gccctgatg  ctctacctg  tgtgagcta  ccactggga  gtatggctg  720
tgtccaatg  ccaacgcca  ctgctgttc  gaccacctg  actgctgcc  ccaggacac  780
gtatgtgac  tgatccaga  caagtgcat  tccaaggac  acaccacag  tctcatgac  840
aagctgcct  gatacccag  gaatgaggt  aagtgcgac  tggaggtga  ctgtcctga  900
ggctacacc  gctgccgcc  caacactgg  gcctggggc  gctgtccat  caccaaggc  960
gtgtgttgt  aagaccaca  tcactgctg  ccagccggg  ttcagtgtc  cacagagac  1020
ggaacctgt  aactgggag  ccttcaggt  ccctggatg  aaaaggtca  ggcctccct  1080
agcctgcca  acccacaga  cttgaagaa  gatgtcccc  gtgatgact  cagtagctg  1140
ccttctaac  atacctgct  cagactcag  tctggggac  ggggctgct  tcccatccc  1200
gaggctgtc  gctgcttag  ccaccagca  tgctgccct  agggtttca  atgtatgga  1260
gaggggtac  gtcagaagg  agacagaat  gtggctggc  tggagaaga  gcctgtccg  1320
cagacaact  tgctccaac  tggagatat  ggttgtgac  agcatacca  ctgcccagt  1380
gggcaaaca  gctgcccaa  cctgaaggg  agttgggcc  gctgccagt  gccccatgc  1440
gtgtgctgt  aggaccggc  gcactgttg  ccggctggg  acacctgca  cgtgaaggc  1500
agaacctgt  agaaggatg  aggctctgt  cagccttcc  tggacctga  ctttggctc  1560
aaggttggg  atgtggaat  tggtgccgg  catttctgc  atgataacc  gtcctgttg  1620
aaagacagc  aaggaggct  ggcctgctg  ccctatgta  agggtgtct  ctgtagaga  1680
ggacgtcac  gttgtccca  tggcttcca  tgttcagcc  agggaacca  gtgtttgcg  1740
aagaagacc  ctcgctggg  catactttt  agggatcca  ccccaagac  gctactgtg  1800
ggaagggct  acgactaaa  aactccaca  tcctgggaa  cctgttctg  gggtatcca  1860
cactcaggc  tccctggca  ctcttcctt  agtctcccc  gcctactca  tctgagtca  1920
cccatcacc  tggaaggtg  ggcctcaaa  taagacctt  tcttatgga  agaaggctg  1980
ggcaaaagc  ccgtatcaa  ctgccattt  ttctgattt  tgtggacct  gtggccagg  2040
gctcttctc  atccacagg  gttgtgtga  cttgctttt  tgtgtgtgt  tgtgcgcgc  2100
tgcgagcgt  ttgctccaa  aaagtttgt  cactttcaa  aaaaaaaaa  aaa  2153



<210> 9793
<211> 588
<212> PRT
<213> Rattus norvegicus
<308> P23785
<400> 9793

Met Trp Ile Leu Val Ser Trp Leu Ala Leu Val Ala Arg Leu Val Ala 
  1               5                  10                  15
Gly Thr Gln Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
             20                  25                  30
Asp Gln Gly Gly Ala Asn Tyr Ser Cys Cys Asn Pro Leu Leu Asp Thr 
         35                  40                  45
Trp Pro Ile Ile Thr Ser Arg Arg Leu Asp Gly Ser Cys Gln Ile Arg 
     50                  55                  60
Asp His Cys Pro Asp Gly Tyr Ser Cys Leu Leu Thr Val Ser Gly Thr 
 65                  70                  75                  80
Ser Ser Cys Cys Pro Phe Ser Glu Gly Val Ser Cys Asp Asp Gly Gln 
                 85                  90                  95
His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Lys Ser Cys 
             100                105                110
Ser Gln Ile Ser Asp Ser Leu Leu Gly Ala Val Gln Cys Pro Gly Ser 
         115                120                125
Gln Phe Glu Cys Pro Asp Ser Ala Thr Cys Cys Ile Met Ile Asp Gly 
     130                135                140
Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp Arg 
 145                150                155                160
Val His Cys Cys Pro His Gly Ala Ser Cys Asp Leu Val His Thr Arg 
                 165                170                175
Cys Ile Ser Pro Thr Gly Thr His Pro Leu Leu Lys Lys Phe Pro Ala 
             180                185                190
Gln Arg Thr Asn Arg Ala Val Ala Ser Phe Ser Val Val Cys Pro Asp 
         195                200                205
Ala Lys Thr Gln Cys Pro Asp Asp Ser Thr Cys Cys Glu Leu Pro Thr 
     210                215                220
Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Ile Cys Cys Ser Asp 
 225                230                235                240
His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile Gln Ser 
                 245                250                255
Lys Cys Ile Ser Lys Asp Tyr Thr Thr Asp Leu Met Thr Lys Leu Pro 
             260                265                270
Gly Tyr Pro Val Asn Glu Val Lys Cys Asp Leu Glu Val Ser Cys Pro 
         275                280                285
Asp Gly Tyr Thr Cys Cys Arg Leu Asn Thr Gly Ala Trp Gly Cys Cys 
     290                295                300
Pro Phe Thr Lys Ala Val Cys Cys Glu Asp His Ile His Cys Cys Pro 
 305                310                315                320
Ala Gly Phe Gln Cys His Thr Glu Thr Gly Thr Cys Glu Leu Gly Val 
                 325                330                335
Leu Gln Val Pro Trp Met Lys Lys Val Thr Ala Ser Leu Ser Leu Pro 
             340                345                350
Asp Pro Gln Ile Leu Lys Asn Asp Val Pro Cys Asp Asp Phe Ser Ser 
         355                360                365
Cys Pro Ser Asn Asn Thr Cys Cys Arg Leu Ser Ser Gly Asp Trp Gly 
     370                375                380
Cys Cys Pro Met Pro Glu Ala Val Cys Cys Leu Asp His Gln His Cys 
 385                390                395                400
Cys Pro Gln Gly Phe Lys Cys Met Asp Glu Gly Tyr Cys Gln Lys Gly 
                 405                410                415
Asp Arg Met Val Ala Gly Leu Glu Lys Met Pro Val Arg Gln Thr Thr 
             420                425                430
Leu Leu Gln His Gly Asp Ile Gly Cys Asp Gln His Thr Ser Cys Pro 
         435                440                445
Val Gly Gln Thr Cys Cys Pro Ser Leu Lys Gly Ser Trp Ala Cys Cys 
     450                455                460
Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His Cys Cys Pro 
 465                470                475                480
Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Thr Cys Glu Lys Asp Ala 
                 485                490                495
Gly Ser Val Gln Pro Ser Met Asp Leu Thr Phe Gly Ser Lys Val Gly 
             500                505                510
Asn Val Glu Cys Gly Ala Gly His Phe Cys His Asp Asn Gln Ser Cys 
         515                520                525
Cys Lys Asp Ser Gln Gly Gly Trp Ala Cys Cys Pro Tyr Val Lys Gly 
     530                535                540
Val Cys Cys Arg Asp Gly Arg His Cys Cys Pro Ile Gly Phe His Cys 
 545                550                555                560
Ser Ala Lys Gly Thr Lys Cys Leu Arg Lys Lys Thr Pro Arg Trp Asp 
                 565                570                575
Ile Leu Leu Arg Asp Pro Ala Pro Arg Pro Leu Leu 
             580                585



<210> 9794
<211> 2152
<212> DNA
<213> Homo sapiens
<308> X62320
<400> 9794

gctgctgcc  aaggaccgc  gagtcggac  caggcagac  atgtggacc  tggtgagct  60
ggtggcctt  acagcaggg  tggtggctg  aacgcggtg  ccagatggt  agttctgcc  120
tgtggcctg  tgcctggac  ccggaggag  cagctacag  tgctgccgt  cccttctgg  180
caaatggcc  acaacactg  gcaggcatc  gggtggccc  tgccaggtt  atgcccact  240
ctctgccgg  cactcctgc  tctttaccg  ctcagggac  tccagttgc  gccccttcc  300
agaggccgt  gcatgcggg  atggccatc  ctgctgccc  cggggcttc  actgcagtg  360
agacgggcg  tcctgcttc  aaagatcag  taacaactc  gtgggtgcc  tccagtgcc  420
tgatagtca  ttcgaatgc  cggacttct  cacgtgctg  gttatggtc  atggctcct  480
ggggtgctg  cccatgccc  aggcttcct  ctgtgaaga  agggtgcac  gctgtccgc  540
cggtgcctt  tgcgacctg  ttcacaccc  ctgcatcac  cccacgggc  cccaccccc  600
ggcaaagaa  ctccctgcc  agaggacta  cagggcagt  gccttgtcc  gctcggtca  660
gtgtccgga  gcacggtcc  ggtgccctg  tggttctac  tgctgtgag  tgcccagtg  720
gaagtatgg  tgctgccca  tgcccaacg  cacctgctg  tccgatcac  tgcactgct  780
cccccaaga  actgtgtgt  acctgatcc  gagtaagtg  ctctccaag  agaacgcta  840
cacggacct  ctcactaag  tgcctgcgc  cacagtggg  gatgtgaaa  gtgacatgg  900
ggtgagctg  ccagatggc  atacctgct  ccgtctaca  tcgggggcc  ggggctgct  960
cccttttac  caggctgtg  gctgtgagg  ccacataca  tgctgtccc  cggggttta  1020
gtgtgacac  cagaagggt  cctgtgaac  ggggcccca  caggtgccc  ggatggaga  1080
ggccccagc  cacctcagc  tgccagacc  acaagcctt  aagagagat  tcccctgtg  1140
taatgtcag  agctgtccc  cctccgata  ctgctgcca  ctcacgtct  gggagtggg  1200
ctgctgtcc  atcccagag  ctgtctgct  ctcggacca  cagcactgc  gcccccagg  1260
ctacacgtg  gtagctgag  ggcagtgtc  gcgaggaag  gagatcgtg  ctggactgg  1320
gaagatgcc  gcccgccgg  cttccttat  ccaccccag  gacatcggc  gtgaccagc  1380
caccagctg  ccggtgggg  agacctgct  cccgagcct  ggtgggagc  gggcctgct  1440
ccagttgcc  catgctgtg  gctgcgagg  tcgccagca  tgctgcccg  ctggctaca  1500
ctgcaacgt  aaggctcga  cctgcgaga  ggaagtggt  tctgcccag  ctgccacct  1560
cctggcccg  agccctcac  tgggtgtga  ggacgtgga  tgtggggaa  gacacttct  1620
ccatgataa  cagacctgc  gccgagaca  ccgacaggg  tgggcctgc  gtccctacc  1680
ccagggcgt  tgttgtgct  atcggcgcc  ctgctgtcc  gctggcttc  gctgcgcag  1740
caggggtac  aagtgtttg  gcagggagg  cccgcgctg  gacgcccct  tgagggacc  1800
agccttgag  cagctgctg  gagggacag  actgaagac  ctgcagccc  cgggacccc  1860
ctcggaggg  gccctctgc  caggcctcc  tagcacctc  ccctaacca  attctccct  1920
gaccccatt  tgagctccc  atcaccatg  gaggtgggg  ctcaatcta  ggccttccc  1980
gtcagaagg  ggttgtggc  aaagccaca  tacaagctg  catcccctc  ccgtttcag  2040
ggaccctgt  gccaggtgc  tttccctat  cacaggggt  tttgtgtgt  tgcgcgtgt  2100
cgtttcaat  aagtttgta  actttcaaa  aaaaaaaaa  aaaaaaaaa  aa  2152



<210> 9795
<211> 593
<212> PRT
<213> Homo sapiens
<308> P28799
<400> 9795

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
  1               5                  10                  15
Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
             20                  25                  30
Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
         35                  40                  45
Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
     50                  55                  60
Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
 65                  70                  75                  80
Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                 85                  90                  95
His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
             100                105                110
Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
         115                120                125
Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
     130                135                140
Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
 145                150                155                160
Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
                 165                170                175
Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro 
             180                185                190
Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys 
         195                200                205
Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu 
     210                215                220
Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys 
 225                230                235                240
Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile 
                 245                250                255
Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr 
             260                265                270
Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val 
         275                280                285
Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp 
     290                295                300
Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His 
 305                310                315                320
Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                 325                330                335
Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
             340                345                350
Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
         355                360                365
Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly 
     370                375                380
Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His 
 385                390                395                400
Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys 
                 405                410                415
Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg 
             420                425                430
Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr 
         435                440                445
Ser Cys Pro Val Gly Gly Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp 
     450                455                460
Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His 
 465                470                475                480
Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu 
                 485                490                495
Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro 
             500                505                510
His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His 
         515                520                525
Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys 
     530                535                540
Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro 
 545                550                555                560
Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu 
                 565                570                575
Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu 
             580                585                590
Leu 
         595



<210> 9796
<211> 2001
<212> DNA
<213> Rattus norvegicus
<308> X62323
<400> 9796

acctgttgg  tcggacaaa  aactgagtg  cctcctgga  ttcagtatg  tgttcccgc  60
acctgtggc  aatggcaag  gccggcccg  ctccctagc  ggaacccag  tcgcaggct  120
aggactgga  gaccgaccc  gctcagagt  ctggggcaa  agtgaacag  acagttctt  180
ctttgaccc  agccgggca  acagcgaag  tgcccactt  agtgactcc  acagcagcc  240
gccgccttc  acgttccta  gagctgggc  tggaggcaa  ggcagtgaa  ggaatgcct  300
tgccacctt  gggagagac  ccagtgttg  caccctgag  caggctggc  tcctaccag  360
tgagctggg  ctcagcagt  ccgggccac  gtccccatc  ggcgtcaag  gcagctccc  420
gtattacac  tcattcccc  gcaaccctc  gcggagagc  gcagatggt  gcctggcag  480
tactcagcc  aagaaggtc  ggaaggttc  gcctggtct  ccttcctcg  tatatccat  540
cagctcagg  gataactac  gcagggacg  cacagccta  ccctccgcc  agaccccca  600
cagcgctta  ccctccccc  tctacgtgg  agacggcag  ctgcacccc  cagcggagc  660
ctggagtcc  cctggccag  tgggctttg  gcccatgct  ggtgatggc  cggcccccc  720
gccgcttgc  ccgggcagc  gttccgtga  cagtggtgc  tttgggggc  tccagcagc  780
ggatcgcat  ggctaccag  tgcatgggt  tgaggtcaa  ggtacgctc  cagctgtat  840
cagcttctc  gctgcccct  gcacttaca  tgggacttc  ggccacacg  cacccgtga  900
cggggccga  agcctctta  gcacccgag  gactacagc  agcagctca  gggatgccc  960
tgggaaggc  ctggcctcc  tctactccc  ggatcactc  agcaataat  tctcgccca  1020
cccctcaac  cctgtgggt  caccccagg  cctgccagg  acatcacag  ggccccggg  1080
aggagcgcc  agtgcctta  cccccaact  cgatgcagg  ctccatggc  tgagtaaaa  1140
ggaagatcg  ttggacgag  ccatccacg  cctccgcag  cacgctgtc  gcactgcaa  1200
cgagctcca  ggactgctg  ctggccaca  cacgttgac  acaagcttt  cgggcccca  1260
gtcactggg  gggcggcat  caggcctgg  cagcggaag  caccctgag  atggcctca  1320
aagtggtgc  agtcttttg  ataaccatg  cagccttcc  agccagccc  gctccctcc  1380
tgacctctc  cagaggcca  ccgactcct  tagtggact  gggagggca  gcgtgactg  1440
aggcgccag  gagatcaag  gggaggaga  agaggacga  gaggtcaca  cagtggcag  1500
cgctgagga  gacaagaag  acctgaagg  cccacgcac  cgtaccagc  gtacagatg  1560
ggtgctgtc  ctggaggag  aggacctga  ggaccggga  aggcgcatg  ccaataacg  1620
tcgggagcg  gtgcgcgtg  gggacatta  cgaggcctt  cgggagctg  gccgcatgt  1680
ccagctgca  ctcaagtcg  ataaggcgc  gaccaagct  ctgatcctg  agcaggcgg  1740
gcaggttat  ctgggcctg  agcagcagg  gcgagaacg  aacctgaac  ccaaagcag  1800
ctgcttgaa  cggcgggag  aggagaagg  atctggcgt  gtcggggat  cgcagctgg  1860
gctgtcagc  gcccacccg  gcctgggtg  ggcccacaa  ccagctggg  acctgtgag  1920
cgtcacagg  tcttcgttg  accagggac  accacatct  tgcccgggg  gcacccagg  1980
tggtcctgg  tgagacatc  c  2001



<210> 9797
<211> 649
<212> PRT
<213> Rattus norvegicus
<308> P21677
<400> 9797

Met Met Asn Gln Ser Gln Arg Met Ala Pro Val Gly Ser Asp Lys Glu 
  1               5                  10                  15
Leu Ser Asp Leu Leu Asp Phe Ser Met Met Phe Pro Leu Pro Val Ala 
             20                  25                  30
Asn Gly Lys Gly Arg Pro Ala Ser Leu Ala Gly Thr Gln Phe Ala Gly 
         35                  40                  45
Ser Gly Leu Glu Asp Arg Pro Ser Ser Glu Ser Trp Gly Asn Ser Glu 
     50                  55                  60
Gln Asn Ser Ser Ser Phe Asp Pro Ser Arg Ala Tyr Ser Glu Gly Ala 
 65                  70                  75                  80
His Phe Ser Asp Ser His Ser Ser Leu Pro Pro Ser Thr Phe Leu Gly 
                 85                  90                  95
Ala Gly Leu Gly Gly Lys Gly Ser Glu Arg Asn Ala Tyr Ala Thr Phe 
             100                105                110
Gly Arg Asp Thr Ser Val Gly Thr Leu Ser Gln Ala Gly Phe Leu Pro 
         115                120                125
Gly Glu Leu Gly Leu Ser Ser Pro Gly Pro Leu Ser Pro Ser Gly Val 
     130                135                140
Lys Ser Ser Ser Gln Tyr Tyr Thr Ser Phe Pro Ser Asn Pro Arg Arg 
 145                150                155                160
Arg Ala Ala Asp Gly Gly Leu Asp Thr Gln Pro Lys Lys Val Arg Lys 
                 165                170                175
Val Pro Pro Gly Leu Pro Ser Ser Val Tyr Pro Ser Ser Ser Gly Asp 
             180                185                190
Asn Tyr Ser Arg Asp Ala Thr Ala Tyr Pro Ser Ala Lys Thr Pro Ser 
         195                200                205
Ser Ala Tyr Pro Ser Pro Phe Tyr Val Ala Asp Gly Ser Leu His Pro 
     210                215                220
Ser Ala Glu Leu Trp Ser Pro Pro Gly Gln Val Gly Phe Gly Pro Met 
 225                230                235                240
Leu Gly Asp Gly Ser Ala Pro Leu Pro Leu Ala Pro Gly Ser Ser Ser 
                 245                250                255
Val Ser Ser Gly Ala Phe Gly Gly Leu Gln Gln Gln Asp Arg Met Gly 
             260                265                270
Tyr Gln Leu His Gly Ser Glu Val Asn Gly Thr Leu Pro Ala Val Ser 
         275                280                285
Ser Phe Ser Ala Ala Pro Gly Thr Tyr Ser Gly Thr Ser Gly His Thr 
     290                295                300
Pro Pro Val Ser Gly Ala Asp Ser Leu Leu Gly Thr Arg Gly Thr Thr 
 305                310                315                320
Ala Ser Ser Ser Gly Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr 
                 325                330                335
Ser Pro Asp His Ser Ser Asn Asn Phe Ser Pro Ser Pro Ser Thr Pro 
             340                345                350
Val Gly Ser Pro Gln Gly Leu Pro Gly Thr Ser Gln Trp Pro Arg Ala 
         355                360                365
Gly Ala Pro Ser Ala Leu Ser Pro Asn Tyr Asp Ala Gly Leu His Gly 
     370                375                380
Leu Ser Lys Met Glu Asp Arg Leu Asp Glu Ala Ile His Val Leu Arg 
 385                390                395                400
Ser His Ala Val Gly Thr Ala Ser Glu Leu His Gly Leu Leu Pro Gly 
                 405                410                415
His Ser Thr Leu Thr Thr Ser Phe Ala Gly Pro Met Ser Leu Gly Gly 
             420                425                430
Arg His Ala Gly Leu Val Ser Gly Ser His Pro Glu Asp Gly Leu Thr 
         435                440                445
Ser Gly Ala Ser Leu Leu His Asn His Ala Ser Leu Pro Ser Gln Pro 
     450                455                460
Ser Ser Leu Pro Asp Leu Ser Gln Arg Pro Pro Asp Ser Phe Ser Gly 
 465                470                475                480
Leu Gly Arg Ala Gly Val Thr Ala Gly Ala Ser Glu Ile Lys Arg Glu 
                 485                490                495
Glu Lys Glu Asp Glu Glu Val Thr Ser Val Ala Asp Ala Glu Glu Asp 
             500                505                510
Lys Lys Asp Leu Lys Val Pro Arg Thr Arg Thr Ser Pro Asp Glu Asp 
         515                520                525
Glu Asp Asp Leu Leu Pro Pro Glu Gln Lys Ala Glu Arg Glu Lys Glu 
     530                535                540
Arg Arg Val Ala Asn Asn Ala Arg Glu Arg Leu Arg Val Arg Asp Ile 
 545                550                555                560
Asn Glu Ala Phe Lys Glu Leu Gly Arg Met Cys Gln Leu His Leu Ser 
                 565                570                575
Thr Glu Lys Pro Gln Thr Lys Leu Leu Ile Leu His Gln Ala Val Ala 
             580                585                590
Val Ile Leu Ser Leu Glu Gln Gln Val Arg Glu Arg Asn Leu Asn Pro 
         595                600                605
Lys Ala Ala Cys Leu Lys Arg Arg Glu Glu Glu Lys Val Ser Gly Val 
     610                615                620
Val Gly Asp Pro Gln Leu Ala Leu Ser Ala Ala His Pro Gly Leu Gly 
 625                630                635                640
Glu Ala His Asn Pro Ala Gly His Leu 
                 645



<210> 9798
<211> 258
<212> DNA
<213> Homo sapiens
<308> AA504291
<400> 9798

gggcggcaa  cacacggag  accccagca  ctgcacctg  gtgcgggga  gggagaggg  60
gctggggca  ccctggccg  ggagcctac  tcgcacctg  tgctccagc  ccaggatga  120
ctgcacggc  tgctgcagg  tgagcagct  ggtctgcgc  ttgtccgac  tgaggtgca  180
ctggcacat  cgccccagc  cccggaagg  ctcgttaat  tcccgcacg  gcacccgct  240
ccgcgcgtt  ttggccat  258



<210> 9799
<211> 654
<212> PRT
<213> Homo sapiens
<308> XP_047600
<400> 9799

Met Asn Gln Pro Gln Arg Met Ala Pro Val Gly Thr Asp Lys Glu Leu 
  1               5                  10                  15
Ser Asp Leu Leu Asp Phe Ser Met Met Phe Pro Leu Pro Val Thr Asn 
             20                  25                  30
Gly Lys Gly Arg Pro Ala Ser Leu Ala Gly Ala Gln Phe Gly Gly Ser 
         35                  40                  45
Gly Leu Glu Asp Arg Pro Ser Ser Gly Ser Trp Gly Ser Gly Asp Gln 
     50                  55                  60
Ser Ser Ser Ser Phe Asp Pro Ser Arg Thr Phe Ser Glu Gly Thr His 
 65                  70                  75                  80
Phe Thr Glu Ser His Ser Ser Leu Ser Ser Ser Thr Phe Leu Gly Pro 
                 85                  90                  95
Gly Leu Gly Gly Lys Ser Gly Glu Arg Gly Ala Tyr Ala Ser Phe Gly 
             100                105                110
Arg Asp Ala Gly Val Gly Gly Leu Thr Gln Ala Gly Phe Leu Ser Gly 
         115                120                125
Glu Leu Ala Leu Asn Ser Pro Gly Pro Leu Ser Pro Ser Gly Met Lys 
     130                135                140
Gly Thr Ser Gln Tyr Tyr Pro Ser Tyr Ser Gly Ser Ser Arg Arg Arg 
 145                150                155                160
Ala Ala Asp Gly Ser Leu Asp Thr Gln Pro Lys Lys Val Arg Lys Val 
                 165                170                175
Pro Pro Gly Leu Pro Ser Ser Val Tyr Pro Pro Ser Ser Gly Glu Asp 
             180                185                190
Tyr Gly Arg Asp Ala Thr Ala Tyr Pro Ser Ala Lys Thr Pro Ser Ser 
         195                200                205
Thr Tyr Pro Ala Pro Phe Tyr Val Ala Asp Gly Ser Leu His Pro Ser 
     210                215                220
Ala Glu Leu Trp Ser Pro Pro Gly Gln Ala Gly Phe Gly Pro Met Leu 
 225                230                235                240
Gly Gly Gly Ser Ser Pro Leu Pro Leu Pro Pro Gly Ser Gly Pro Val 
                 245                250                255
Gly Ser Ser Gly Ser Ser Ser Thr Phe Gly Gly Leu His Gln His Glu 
             260                265                270
Arg Met Gly Tyr Gln Leu His Gly Ala Glu Val Asn Gly Gly Leu Pro 
         275                280                285
Ser Ala Ser Ser Phe Ser Ser Ala Pro Gly Ala Thr Tyr Gly Gly Val 
     290                295                300
Ser Ser His Thr Pro Pro Val Ser Gly Ala Asp Ser Leu Leu Gly Ser 
 305                310                315                320
Arg Gly Thr Thr Ala Gly Ser Ser Gly Asp Ala Leu Gly Lys Ala Leu 
                 325                330                335
Ala Ser Ile Tyr Ser Pro Asp His Ser Ser Asn Asn Phe Ser Ser Ser 
             340                345                350
Pro Ser Thr Pro Val Gly Ser Pro Gln Gly Leu Ala Gly Thr Ser Gln 
         355                360                365
Trp Pro Arg Ala Gly Ala Pro Gly Ala Leu Ser Pro Ser Tyr Asp Gly 
     370                375                380
Gly Leu His Gly Leu Gln Ser Lys Ile Glu Asp His Leu Asp Glu Ala 
 385                390                395                400
Ile His Val Leu Arg Ser His Ala Val Gly Thr Ala Gly Asp Met His 
                 405                410                415
Thr Leu Leu Pro Gly His Gly Ala Leu Ala Ser Gly Phe Thr Gly Pro 
             420                425                430
Met Ser Leu Gly Gly Arg His Ala Gly Leu Val Gly Gly Ser His Pro 
         435                440                445
Glu Asp Gly Leu Ala Gly Ser Thr Ser Leu Met His Asn His Ala Ala 
     450                455                460
Leu Pro Ser Gln Pro Gly Thr Leu Pro Asp Leu Ser Arg Pro Pro Asp 
 465                470                475                480
Ser Tyr Ser Gly Leu Gly Arg Ala Gly Ala Thr Ala Ala Ala Ser Glu 
                 485                490                495
Ile Lys Arg Glu Glu Lys Glu Asp Glu Glu Asn Thr Ser Ala Ala Asp 
             500                505                510
His Ser Glu Glu Glu Lys Lys Glu Leu Lys Ala Pro Arg Ala Arg Thr 
         515                520                525
Ser Pro Asp Glu Asp Glu Asp Asp Leu Leu Pro Pro Glu Gln Lys Ala 
     530                535                540
Glu Arg Glu Lys Glu Arg Arg Val Ala Asn Asn Ala Arg Glu Arg Leu 
 545                550                555                560
Arg Val Arg Asp Ile Asn Glu Ala Phe Lys Glu Leu Gly Arg Met Cys 
                 565                570                575
Gln Leu His Leu Asn Ser Glu Lys Pro Gln Thr Lys Leu Leu Ile Leu 
             580                585                590
His Gln Ala Val Ser Val Ile Leu Asn Leu Glu Gln Gln Val Arg Glu 
         595                600                605
Arg Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys Arg Arg Glu Glu Glu 
     610                615                620
Lys Val Ser Gly Val Val Gly Asp Pro Gln Met Val Leu Ser Ala Pro 
 625                630                635                640
His Pro Gly Leu Ser Glu Ala His Asn Pro Ala Gly His Met 
                 645                650



<210> 9800
<211> 410
<212> DNA
<213> Rattus norvegicus
<308> X62325
<400> 9800

atgaaatcc  tgagtgttt  actagtgct  ctgtggctc  agctaaacg  ggtgagcag  60
cagcagaag  tgcagcaga  cccagaatc  ctcattgtc  cagagggag  caaagcctc  120
ttcaactgc  ctttcagtg  tagtacttc  gattatttc  ggtggttca  acagtattc  180
gggaaaagc  ccaaggccc  gatgtccat  ttctccaat  gtgacaagc  agaaggcag  240
ttcacagtt  acctcaata  aaccagcct  catgtttcc  tgcacatca  tgactccca  300
cccactgac  ctgctgtct  cctctgtgc  gtgagtgcg  aaataatgc  ggtgccaag  360
tcacgtttg  agggggaac  aggttgacg  tcaaacccc  tgtcacagac  410



<210> 9801
<211> 410
<212> DNA
<213> Rattus norvegicus
<308> X62325
<400> 9801

atgaaatcc  tgagtgttt  actagtgct  ctgtggctc  agctaaacg  ggtgagcag  60
cagcagaag  tgcagcaga  cccagaatc  ctcattgtc  cagagggag  caaagcctc  120
ttcaactgc  ctttcagtg  tagtacttc  gattatttc  ggtggttca  acagtattc  180
gggaaaagc  ccaaggccc  gatgtccat  ttctccaat  gtgacaagc  agaaggcag  240
ttcacagtt  acctcaata  aaccagcct  catgtttcc  tgcacatca  tgactccca  300
cccactgac  ctgctgtct  cctctgtgc  gtgagtgcg  aaataatgc  ggtgccaag  360
tcacgtttg  agggggaac  aggttgacg  tcaaacccc  tgtcacagac  410



<210> 9802
<211> 893
<212> DNA
<213> Rattus norvegicus
<308> X62660
<400> 9802

ccaataagg  aactctgaa  caggagtca  ggaagtcaa  cccaagctc  actactttc  60
aggcagggg  aggatggag  cgatccgct  gctgctggc  acagctgga  tggagtttg  120
agaagaatt  cttgagacg  gagaacaat  tgagaagtt  caaaaggat  gatgcctgc  180
ttttggcca  gtcccattg  tggaaatag  cgggatgct  ctgacacag  ccagagcca  240
cctcagcta  ctggccgcc  agtacaact  gtatgggaa  gacctgaag  agagagtca  300
gattgacat  tatgccgat  gcacccagg  cctgatgat  atgattatc  gggctccat  360
taaagcccc  caggaaaaa  aagagagcc  agctttagc  gtgaagagg  ctaaaaacc  420
ttacttccc  gtgtttgaa  agattttaa  agaccatgg  gaggcattt  ttgttggca  480
ccaactcag  tgggcagac  tacagctac  agaagccat  ttgatggtg  aagaagtca  540
tgctcctgt  ttgtctgac  tccctctgc  gcaggcatt  aagacaaga  tcagcaaca  600
tcctacaat  aagaagttc  tgcaacctg  aagtcagag  aagccacct  cggatggcc  660
ctatgttga  gtggtcagg  ccgtcctga  gttctagtg  cagcgtgct  taaagtggc  720
actgcaagg  tccaatcac  gcagcagct  cagagcatt  cagaggcaa  atagagctc  780
caggagtaa  ggtcttcaa  gaacctgaa  accactctg  ccaacaatg  caaatgcca  840
ttaaataga  tgaaaaact  ttaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaa  893



<210> 9803
<211> 222
<212> PRT
<213> Rattus norvegicus
<308> CAB46530
<400> 9803

Met Glu Val Lys Pro Lys Leu Tyr Tyr Phe Gln Gly Arg Gly Arg Met 
  1               5                  10                  15
Glu Ser Ile Arg Trp Leu Leu Ala Thr Ala Gly Val Glu Phe Glu Glu 
             20                  25                  30
Glu Phe Leu Glu Thr Arg Glu Gln Tyr Glu Lys Leu Gln Lys Asp Gly 
         35                  40                  45
Cys Leu Leu Phe Gly Gln Val Pro Leu Val Glu Ile Asp Gly Met Leu 
     50                  55                  60
Leu Thr Gln Thr Arg Ala Ile Leu Ser Tyr Leu Ala Ala Lys Tyr Asn 
 65                  70                  75                  80
Leu Tyr Gly Lys Asp Leu Lys Glu Arg Val Arg Ile Asp Met Tyr Ala 
                 85                  90                  95
Asp Gly Thr Gln Asp Leu Met Met Met Ile Ile Gly Ala Pro Phe Lys 
             100                105                110
Ala Pro Gln Glu Lys Glu Glu Ser Leu Ala Leu Ala Val Lys Arg Ala 
         115                120                125
Lys Asn Arg Tyr Phe Pro Val Phe Glu Lys Ile Leu Lys Asp His Gly 
     130                135                140
Glu Ala Phe Leu Val Gly Asn Gln Leu Ser Trp Ala Asp Ile Gln Leu 
 145                150                155                160
Leu Glu Ala Ile Leu Met Val Glu Glu Val Ser Ala Pro Val Leu Ser 
                 165                170                175
Asp Phe Pro Leu Leu Gln Ala Phe Lys Thr Arg Ile Ser Asn Ile Pro 
             180                185                190
Thr Ile Lys Lys Phe Leu Gln Pro Gly Ser Gln Arg Lys Pro Pro Pro 
         195                200                205
Asp Gly His Tyr Val Asp Val Val Arg Thr Val Leu Lys Phe 
     210                215                220



<210> 9804
<211> 918
<212> DNA
<213> Homo sapiens
<308> NM_000847
<400> 9804

ggtggcctt  agaagctga  cggagaccg  ctagacttt  ctcaaagaa  ccaagagac  60
gttaccatg  cagggaagc  caagcttca  tacttcaat  gacggggca  aatggagcc  120
atccggtgg  tcttggctg  agctggagt  gagtttgaa  agaaattta  aggatctgc  180
gaagatttg  gaaagttaa  aaatgatgg  agtttgatg  tccagcaag  accaatggt  240
gagattgat  ggattaagt  ggtacagac  agagccatt  tcaactaca  tgccagcaa  300
tacaacctc  acgggaaag  cataaagga  agagcccta  ttgatatgt  tacagaagg  360
atggcagat  tgaatgaaa  gatccttct  ctgccctta  gtcgacctg  ggaaaaaga  420
gccaagatt  ccttgatca  agagaaaac  aaaagtcgc  atttccctg  cttcgaaaa  480
gtgttacag  gccatggac  agactacct  gttggcaac  agctgagcc  ggctgacat  540
agcctggtg  aacttctct  ctatgtgga  gagcttgac  ccagcctta  ctccaactt  600
cctctgctg  aggccctga  aaccagaat  agcaacctg  ccacggtga  gaagtttct  660
cagcctggc  gcccaagga  gcctcccgc  gatgcaaaa  ctttagaag  agccagaaa  720
attttcagg  tttaataaa  cagccatgg  ggctaagaa  atgcaagac  aatattcta  780
agttttgca  caatgaagt  ctttactta  gtgttgatt  tgcctgttg  aaagctaat  840
aaccctttc  aattatatg  taattaaat  ataaaaact  ctatttgca  aaaaaaaaa  900
aaaaaaaaa  aaaaaaaa  918



<210> 9805
<211> 222
<212> PRT
<213> Homo sapiens
<308> Q16772
<400> 9805

Met Ala Gly Lys Pro Lys Leu His Tyr Phe Asn Gly Arg Gly Arg Met 
  1               5                  10                  15
Glu Pro Ile Arg Trp Leu Leu Ala Ala Ala Gly Val Glu Phe Glu Glu 
             20                  25                  30
Lys Phe Ile Gly Ser Ala Glu Asp Leu Gly Lys Leu Arg Asn Asp Gly 
         35                  40                  45
Ser Leu Met Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys 
     50                  55                  60
Leu Val Gln Thr Arg Ala Ile Leu Asn Tyr Ile Ala Ser Lys Tyr Asn 
 65                  70                  75                  80
Leu Tyr Gly Lys Asp Ile Lys Glu Arg Ala Leu Ile Asp Met Tyr Thr 
                 85                  90                  95
Glu Gly Met Ala Asp Leu Asn Glu Met Ile Leu Leu Leu Pro Leu Cys 
             100                105                110
Arg Pro Glu Glu Lys Asp Ala Lys Ile Ala Leu Ile Lys Glu Lys Thr 
         115                120                125
Lys Ser Arg Tyr Phe Pro Ala Phe Glu Lys Val Leu Gln Ser His Gly 
     130                135                140
Gln Asp Tyr Leu Val Gly Asn Lys Leu Ser Arg Ala Asp Ile Ser Leu 
 145                150                155                160
Val Glu Leu Leu Tyr Tyr Val Glu Glu Leu Asp Ser Ser Leu Ile Ser 
                 165                170                175
Asn Phe Pro Leu Leu Lys Ala Leu Lys Thr Arg Ile Ser Asn Leu Pro 
             180                185                190
Thr Val Lys Lys Phe Leu Gln Pro Gly Ser Pro Arg Lys Pro Pro Ala 
         195                200                205
Asp Ala Lys Ala Leu Glu Glu Ala Arg Lys Ile Phe Arg Phe 
     210                215                220



<210> 9807
<211> 638
<212> PRT
<213> Rattus norvegicus
<308> CAA44643
<400> 9807

Met Gly Lys Ile Glu Asn Asn Glu Arg Val Ile Leu Asn Val Gly Gly 
  1               5                  10                  15
Thr Arg His Glu Thr Tyr Arg Ser Thr Leu Lys Thr Leu Pro Gly Thr 
             20                  25                  30
Arg Leu Ala Leu Leu Ala Ser Ser Glu Pro Gln Gly Asp Cys Leu Thr 
         35                  40                  45
Ala Ala Gly Asp Lys Leu Gln Pro Leu Pro Pro Pro Leu Ser Pro Pro 
     50                  55                  60
Pro Arg Pro Pro Pro Leu Ser Pro Val Pro Ser Gly Cys Phe Glu Gly 
 65                  70                  75                  80
Gly Ala Gly Asn Cys Ser Ser His Gly Gly Asn Gly Ser Asp His Pro 
                 85                  90                  95
Gly Gly Gly Arg Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe Ala 
             100                105                110
Tyr Val Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala Asp 
         115                120                125
Val Cys Gly Pro Leu Phe Glu Glu Glu Leu Ala Phe Trp Gly Ile Asp 
     130                135                140
Glu Thr Asp Val Glu Pro Cys Cys Trp Met Thr Tyr Arg Gln His Arg 
 145                150                155                160
Asp Ala Glu Glu Ala Leu Asp Ile Phe Glu Thr Pro Asp Leu Ile Gly 
                 165                170                175
Gly Asp Pro Gly Asp Asp Glu Asp Leu Gly Gly Lys Arg Leu Gly Ile 
             180                185                190
Glu Asp Ala Ala Gly Leu Gly Gly Pro Asp Gly Lys Ser Gly Arg Trp 
         195                200                205
Arg Lys Leu Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser 
     210                215                220
Ser Arg Ala Ala Arg Phe Ile Ala Phe Ala Ser Leu Phe Phe Ile Leu 
 225                230                235                240
Val Ser Ile Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile 
                 245                250                255
Val Lys Asn Lys Thr Glu Pro Val Ile Asn Gly Thr Ser Ala Val Leu 
             260                265                270
Gln Tyr Glu Ile Glu Thr Asp Pro Ala Leu Thr Tyr Val Glu Gly Val 
         275                280                285
Cys Val Val Trp Phe Thr Phe Glu Phe Leu Val Arg Ile Val Phe Ser 
     290                295                300
Pro Asn Lys Leu Glu Phe Ile Lys Asn Leu Leu Asn Ile Ile Asp Phe 
 305                310                315                320
Val Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser 
                 325                330                335
Ser Lys Ala Ala Lys Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe 
             340                345                350
Val Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu 
         355                360                365
Arg Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu 
     370                375                380
Leu Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile 
 385                390                395                400
Tyr Tyr Ala Glu Arg Val Gly Ala Gln Pro Asn Asp Pro Ser Ala Ser 
                 405                410                415
Glu His Thr Gln Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val 
             420                425                430
Val Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Gln Thr Trp 
         435                440                445
Ser Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr 
     450                455                460
Ile Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr 
 465                470                475                480
Ser Leu Ala Met Ala Lys Gln Lys Leu Pro Arg Lys Arg Lys Lys His 
                 485                490                495
Ile Pro Pro Ala Pro Leu Ala Ser Ser Pro Thr Phe Cys Lys Thr Glu 
             500                505                510
Leu Asn Met Ala Cys Asn Ser Thr Gln Ser Asp Thr Cys Leu Gly Lys 
         515                520                525
Glu Asn Arg Leu Leu Glu His Asn Arg Ser Val Leu Ser Gly Asp Asp 
     530                535                540
Ser Thr Gly Ser Glu Pro Pro Leu Ser Pro Pro Glu Arg Leu Pro Ile 
 545                550                555                560
Arg Arg Ser Ser Thr Arg Asp Lys Asn Arg Arg Gly Glu Thr Cys Phe 
                 565                570                575
Leu Leu Thr Thr Gly Asp Tyr Thr Cys Ala Ser Asp Gly Gly Ile Arg 
             580                585                590
Lys Gly Tyr Glu Lys Ser Arg Ser Leu Asn Asn Ile Ala Gly Leu Ala 
         595                600                605
Gly Asn Ala Leu Arg Leu Ser Pro Val Thr Ser Pro Tyr Asn Ser Pro 
     610                615                620
Cys Pro Leu Arg Arg Ser Arg Ser Pro Ile Pro Ser Ile Leu 
 625                630                635



<210> 9808
<211> 31737
<212> DNA
<213> Homo sapiens
<308> AL137790
<400> 9808

gatccgagg  ttgcttctc  gaggacctg  ttacccaca  tgcctccat  tcctcccct  3180
tgcctctct  ttttcttca  ttcccctgg  ttcttgcca  ggagcaact  cgaggaagc  3240
tctgaagcc  cctgtggcc  cctgcgtgg  ctccctcag  gtctttcac  ggcagcact  3300
acccttcct  ctccaggct  tgggttttc  tcttgcctc  gctgcttct  cttctctga  3360
tccctttca  gagactctc  ctcttccct  cattcagtg  tggagatag  agcaggctt  3420
tgcttctta  ccctctgta  ctacagcca  agcctcagc  cctgccagc  cacctgcta  3480
tcagaaagt  tatctccag  ttgtctctc  ctggctcca  gctcatctg  ccagcggac  3540
acttggcat  tcattttag  tgtcttaaa  acacattca  ctcaacctt  gtagaacta  3600
tgtcctgat  ctccctgcc  aacaccatc  acctgttcc  ctcccactg  ccccatctc  3660
acctgctca  gtatgcagg  cagagacat  gccctcacc  cggcctctc  ctctccagc  3720
tctcccatc  ccagtccat  ccgaaggtc  ccttggttt  tcctgcgaa  atctctcca  3780
tggcaccac  cagcccctt  gcaaagcca  tgtcccctc  agcctggac  ccagaagcc  3840
cttccttga  ggtctgctg  atccactta  ttcttttgg  aatgcacat  attgtgtcc  3900
cacttcttt  aacccctcg  tggcttctt  ggttaggtg  tttcttagg  tgaagacag  3960
atctgtaca  gcctttgat  taacttctc  cctctccca  ccctacctg  gccaccccc  4020
cctcgtcct  actgcttca  ccaccctgg  accttccat  cccttttac  caccatcct  4080
tgtcctatc  caggacctc  gtccatgct  cttcccgaa  gttcttccc  ccccttgtg  4140
cctcgcttt  atcagcttt  aaatgtcag  ttgaggacc  cttcttctg  gaagccttg  4200
ctggcctcc  aacttgttc  gatcccctt  ttatgggct  tccaagcac  gggtgccca  4260
ccttcacag  ccttgtcac  tttgcaatt  agcatttgt  cgtgggatc  tttgaccaa  4320
gtgtctctc  ccaactaga  tgtaaactt  gagagcctg  ttgcttcta  tccccatgg  4380
ctctgcatc  cctagcacc  ggcctggcc  acagcaggt  ctcagagat  gatggatga  4440
tggctacat  tcattgcca  agggaggcc  tgacacctt  tacctaata  gtacacagg  4500
gtgggctgg  gagagggtc  cctcataga  gccaagggg  ccttagatc  ttaaggcct  4560
ggttctggg  tttcttggt  gactaaaga  ggttttact  attttgtgc  ggatggggg  4620
ccttaatct  ccctggagt  cacatgctg  ctgaccagg  agtcctcct  ggtctccat  4680
tgtgcccag  ccctgaagc  caaaggctc  actaccatc  cccacctct  tcccctcag  4740
atgggggtg  cgccctcag  ctcactgct  tgccagcgc  ctgagcttg  caacatctc  4800
gctgttgga  tgctgccag  agttgagac  tgcctagga  gctgctgag  tgatggcag  4860
tgggccctg  gtcctggat  ttatttagg  ctgtgatat  aaagacagc  aaagtccag  4920
cggacccta  agtccaaca  ctcactgtt  aggtgagga  ttacccaca  gtactcaga  4980
ggggcagcc  ggccaggac  cacacaggg  ttgtcacca  agggaagtg  actctctga  5040
ttggctcct  gcctcctta  tctgtctgg  gtgaggtca  ttaggttca  ctcagcagc  5100
aaggtcaca  gggaaaatg  tttaaagag  ataggtgat  gaaaaactg  gtcaggagt  5160
ggtgctggg  ccgggggcg  gggcctggc  cagaatatc  atattttag  tatcactct  5220
ccccgacta  ccagctcca  taccttgag  aagtcattt  atctttggg  tctcagttt  5280
ccctttaaa  acatgaata  taatccttg  ttcctgcac  cccgcaaaa  acaaaacac  5340
ctgtcctga  gaggtcagc  tcattctgt  gggattgag  gccactacg  acaggcatt  5400
cttgttgct  tacatttga  cctcacgtt  actccgaga  tctattact  ttccctttt  5460
ttcagatga  taatctgaa  ctcataaca  agtcagtgc  acttaccaa  agcttcata  5520
ccatttaaa  atgggagtc  ggatttgga  ctggatctg  ctgagactc  aaagctctg  5580
gctgggtcc  aggcttggt  cctgcccca  ggaacaaac  ataaaagga  aataggttg  5640
aaaggggct  tggaaattg  tccatgcca  cccaatgct  ttgcagttc  ggctcctgt  5700
aggtgtgag  gcagatgga  gcttaggcg  aggcccttt  tccaggaat  gtctaggtt  5760
tgtgcttca  gttgggtga  ggtggggaa  agcaggcgg  ttgggtttt  tttcctttc  5820
tgaggtaga  gagtttgag  tggagaagg  gtcagggag  ttctggtat  ctcagtttt  5880
ttgtgctgc  gtgcaagct  ttcactgca  gactctagg  ggcacctgt  acactgtag  5940
ccaagtgaa  ggcactctc  agagctgtg  actacatga  catatgtga  ggccttgac  6000
atgttcctt  gtatgatgg  tgcatggga  gccatggta  cagttaaat  actatgtaa  6060
cactcagca  ttatgttgt  ttaccaagt  ctcacagtc  tcctctgaa  ttgatactc  6120
tgtgatctg  gtattgggg  aactgaggc  cagaggagt  gggaaattg  ccaagttca  6180
acagcttct  accactatg  gctgctgcc  ctgaactct  ttgaggctg  gaaaggggg  6240
gtgcacatg  ataaaacca  cccctctgt  tctcttttc  tcctcctgc  ttggtcttc  6300
gccatagct  gacaagatg  tggaccccc  ggtgtggcg  gaggcagct  cccaggtct  6360
ctttgcctt  ggcctgggc  ttggtggtg  cattgcctt  tccagctac  ataagcagg  6420
caacaactg  cacttcgat  ccgccctgg  gtccttcat  aacttcttc  cgtcagtgt  6480
ggccaccct  gtggtgttt  ctgtgctgg  cttcaaggc  aacatcatg  atgagaagt  6540
tgtggtcga  taggtggca  ctctcctcc  gtccctcct  ctccctgtc  accttacct  6600
ggagtgggc  ggggtgggg  cgcaggtgt  catggggag  gaggtcccc  ccactcaga  6660
tgaggaatg  agatcagag  agcactctc  gtccccagc  ccgggccac  gggacaagc  6720
cagagatgc  tctgtcagt  acccatgag  ttcccacct  ggtgcctgg  aagagcctc  6780
aggatctca  ccattgccc  cccctgcct  cttacctgg  cctctcggt  ttgtgctgc  6840
ggaatgctg  gaaaatcct  gggtacctt  acaccaacg  cctgagccg  gacctcatc  6900
caccccacg  caacttctc  cacctgacc  caaaggact  catggagat  tacaatgtc  6960
tcatgaccg  gaaggagga  cagttctca  ccctgggcc  tgacccctg  cttctggag  7020
acgagctgg  caaggtgcg  ggacaggct  cccttccca  gacaggcag  aacccagag  7080
gcagctgtg  ccggcggga  cttgggctc  ggcctcagg  tgctgacag  tagtcatta  7140
tttacttgg  aagcaagga  ctgctgtgt  tccagaggg  gtgaaaggg  agaaaggta  7200
tggccaaag  ccctgccca  aggtaggct  gagcctaga  aagaagtag  gcagacaca  7260
acctctcag  agtcacagt  agtgtatgg  acgatgttt  catttactg  gtgggcttc  7320
cgtgcatca  tcactgcca  aggtaatat  ctcagaaca  tgccttgac  tggtgtgca  7380
caaagaagt  ttgaagtta  tgtttgccc  ttgctgtct  tctcttttg  cgctcaaga  7440
agctctatg  gttgagtat  catattgtt  cctacctta  agatgagta  cctatgaga  7500
ggggggctt  atcaaggtc  cataactag  aagtcagag  ggcagttag  tgggtccaa  7560
tccagttag  tgggtccag  gcccatgct  aggatcacc  cttgatgct  ctgcccctc  7620
ccaacctgt  cccattcca  tctcactgc  atgatgact  ttagacttt  gggtggtgc  7680
gggggtgct  actcctcct  agtgctcag  cccatgtta  gacaccttg  ttctattta  7740
acttacata  ctggacact  tcaaaatga  tgttctgtt  gaaggggta  caggaaagg  7800
acataccca  agcatcttg  gaaccaggc  ggagccaag  ctcacatgg  gcggagcca  7860
ctcccatca  cctgggtca  ccctgtcct  catgggact  gggaagggg  tgctttccc  7920
gggctctat  ttaaaagtc  gctccattg  atggtacca  cctaatgct  agggagctg  7980
atcctacac  ccaaccctt  ccctgcgga  caagagcaa  agagcccaa  ctcgggccc  8040
ctgccctgg  ttcttcccc  ggtaactgg  agcataaag  acctcccct  ttcacattc  8100
ctgaaaccc  gctcagttc  catgggcat  gcctggttc  ctgaattaa  ctaggttta  8160
agcagtgtt  tcatacaat  caactccga  agcattcaa  tgacaagat  atacactca  8220
ttagtgggg  agaaatgtt  ccttacaat  actgaacat  acagggcaa  gtgtaagtg  8280
cagggggca  tgtgtggtc  cctgaccca  aagcatggc  caagcatta  agcagtgat  8340
ctctacctt  gctacccat  agagttcct  gggtatttt  gtttgtttt  aaaaaaaac  8400
ctgacaccc  gcttcaccc  agaccaatc  agtcattgt  cgtggggtg  gacccaggt  8460
tcggtgttt  taaaggctc  ggtgtgctt  cattgagag  cgaggctga  accactgca  8520
gaagatctg  agttcagaa  ttctgagct  ggagcggcc  cagtgtggc  ggagcaatc  8580
ggaaagaca  cttagagga  cagggtcct  agctgggtg  atttctaaa  atgagcatc  8640
tcacttgaa  cacctaagc  cctggtaca  cccgtagat  ccaggtccc  caggtgaac  8700
cccaagttg  tgtttttga  ctacgtcta  gggattcca  tgcctgcta  agttcgaga  8760
ccactggcc  aaatcaaca  gatttaggt  gaggtggga  cccctgtga  agagggaat  8820
gttattcca  aagtttgaa  ggcagaggg  aggaagcag  gggctcccc  gggaggggt  8880
acctcacag  ccctgcttt  caccccacc  tcagtccgt  cagggcaca  gcctggcct  8940
catcgcctt  actgaggcc  tgacgcact  ccccgcctc  ccgttctgg  ccgtcatgt  9000
cttcttgat  cttatcaac  tgggcctgg  cagcatgat  gggaccatg  caggcatca  9060
cacgcccat  atcgacacc  tcaaggtgc  caaggagat  ttcacaggt  actcctccc  9120
gcccccatg  ccaggctct  caggctgcc  ttgtggaca  caattccgt  ctggcttct  9180
actgggtcc  tcatgaccc  acacccaga  ggctccacc  cacactggg  cacagctgg  9240
gcctggctg  gccactcag  gattagcac  cacaagcca  gaagagaaa  ctacttgga  9300
atctggagc  aacatgagc  gggaggcct  catctaggc  cctttgtta  ttcacttgc  9360
cctctcccc  agggcctgc  gagtcgtct  gggaagtgg  tgctgagtc  tcttgggca  9420
gggcactca  tggccttgc  ccctgttcc  tctttgtca  tccagtccc  ggctgtgtc  9480
acagttccc  tcggggttt  ctgcgttga  ctagggccc  tagagggat  cctctcatc  9540
gcatcccta  agcggggta  ctttctgtt  tcaagtggg  aaactgagg  ggagaaaaa  9600
actggtaac  atcagatga  tcatttaag  taaatacag  aattaagta  cgcacctgc  9660
acgggccag  ccctgtgct  gggcagagg  atgggatga  agttagaca  aacgccttc  9720
tcaggtgct  cccgactag  agagcgggg  tcagaacct  agcatctgg  tccctcgtg  9780
aggactgag  ctgctggca  gagggctgc  ggcatgctt  ggggaggga  gtgatggga  9840
gggcctggg  gcccccgag  cccccaggg  cctgcccac  ctgcacctt  gcccccaaa  9900
cggcctccc  gctctctgt  gtgggctgc  gtgtctttg  attcctcgt  gggctgttg  9960
tcgtccagc  ctccggaaa  tactttgtc  ccatgttcg  tgactactc  gccaccctg  10020
cactcactc  catcgtcat  cttgagaac  tcgctgtgg  ctggattta  ggaaccaag  10080
agtaagagg  acatggggg  aaggtggga  gggaggagg  gtctgtcct  tcatgactc  10140
ctggagagg  agatcatag  gtcacaatg  cagagctga  agtgccctt  cggatcatt  10200
agggaaact  aggtgtagt  caaggacat  gctgcctaa  gccacttgt  cagggagaa  10260
cagagccag  ctgaggact  ggtgtcctg  gtgcaggtc  tggcatcat  cttaaatta  10320
cacagcacc  ttcctgggt  ccaactctt  agaactctg  taagttttt  tgaagggct  10380
agtgggtct  caagaggcc  ttgccctcc  agaacgtgt  gacttcagc  gcctggttc  10440
caattgtaa  ggcctagat  ggggtatga  atgaggtat  attttggcc  caagtttgg  10500
gttgtgcag  gtaagagga  tcagctcta  gaaaggatt  ggtctcaca  cctaggcct  10560
gggcagttg  acacttact  taaactctt  gcctcatcc  tcatgttag  gcaaatacg  10620
gttcccagg  gttctagaa  taggtctct  tgactcact  agcatcgac  atgaccaca  10680
tgtccttgt  cttggcaag  cccacctcc  ctaacccac  tggtctgac  ctccctgat  10740
cctggacct  gtttggcag  ggggctctt  cacaggggc  gtctgcttc  taggagagc  10800
caggagggg  cagggagtg  ggggaagga  actcctctg  ttccacctg  tgtgggcca  10860
ggctgtaag  cactgccac  aaggactct  gctgatttt  gtgtcctgg  ctccttcgg  10920
agtctggtg  tgtccctgt  tgttacttt  aatgcataa  ataaaatgt  tagggttat  10980
taagaaact  attatattg  aaaatagca  aatatcatt  aaaatttgt  atatagtaa  11040
gtatgagca  tttattttt  atgcattgt  acaagatct  gctatagat  taataacag  11100
ggtaacttt  aagtagtga  gaaaatcag  gatgactca  tattttcaa  aactgggat  11160
taatatgaa  atatctgta  tctattggt  acagtcaca  gtattgtta  tactactgt  11220
tttgcttgc  ttcataata  aatagaaag  aatgcaaga  tttagttag  ggttattga  11280
gtaaagatg  ttcttttgt  tgccattca  gcacaagcc  gcctgcctt  cagaattct  11340
ctcacccct  ggtgagaaa  ccctgagtc  gggcagctc  ctacctttg  actctagag  11400
agtgcactt  tactgcttt  ccagcaggg  gagccttca  ccaggccag  gtgaaaggg  11460
taggcccct  cctgaacac  caagctgtc  atacataaa  cagacgtgc  cctgcccag  11520
gtgtgtctg  tgggcccta  catatctct  gatggggta  gatgtgacg  aatcagaag  11580
ggttagagg  ggacagtag  gccttccca  aggccagcc  gaccacaca  aatgagcac  11640
gaatgtgaa  aatagaaga  cccaggagg  agggactgg  aaacgaaga  tttctggag  11700
agatggtga  gggggaaga  ggaggtgtg  ctgagggat  ccaactgct  gaccctctg  11760
tatgcctgg  aggttcatg  aggagctga  ggagatgct  ggcttccgc  cctaccgct  11820
ctatttcta  atgtggaag  tcgtgtctc  actatgcat  gctgtgctc  ccacagcca  11880
catcatcca  ctgggggtc  cgcccccgg  ctacagcgc  tggatcaag  aggaggtga  11940
gggtggggc  ccaaacccc  gggacattt  catcttctc  ggccttgaa  gcaaccact  12000
atagggata  acctttcta  ggcagctgc  atgtgccag  ccttgccag  tgcctcaca  12060
ctaaaccgc  atcttacaa  aagccaaag  cagaggtgg  atcatccct  tagcacaaa  12120
ggggacacc  aggctcaga  agattaatg  acttatcca  tctttctaa  ccatattct  12180
tctccatgc  tgtggagtg  aattagtcc  ttttatagt  ggagaaacc  ccctagacc  12240
tttcaccaa  gtgaccagg  aaaccccca  ccttggctg  gcctggcca  gatggtggg  12300
ggggagagg  gtggaaggc  atgggtgag  gcaggagag  agtcttgga  ggcctgggc  12360
gggagggct  tcacagtgc  ggcagcagc  cttaaggca  cccacccgc  ggctgccga  12420
cgctacctg  atttcccca  ctgggccat  gcactcctg  tcaccctca  cgtcgtggc  12480
acgctgccc  tccctgtgg  gttcgtcct  cggcacttc  acctgctct  tgatggctc  12540
aacaccctc  ccgtgtcct  caagaaggg  cgcatgatg  aggacatct  caacctgga  12600
gagaacgat  agacccgct  catcctcag  aaggtgccc  gtgaggcac  ttcccccat  12660
cccactcac  gttcctatc  ggggcccgg  agcacatca  ccctggaga  cagcggtaa  12720
cccaatgga  gctatggga  cggctacct  ctggccagc  cccctgagt  ggagctgtg  12780
ccactgccc  agccctgcc  gcctctccc  ccacgctca  cctgcccac  tgtccaggc  12840
tggcctctt  cttgaggtg  ccaccaggc  caggccagg  cctttgccc  agaagagag  12900
gtctgccct  cctcactcc  ctcttcagt  ccagtagac  ctgctccct  gccctgagc  12960
ggaggctgg  agcagctct  tttcctaat  caggacccc  ctcatctag  cctccaaga  13020
cctccgcca  attgtagcc  tgtaattgg  acaacccat  aggcctgct  cccagtcca  13080
gggagattc  aagtggcca  tgcaggagt  actcacctc  ctctctccc  gtaacttgc  13140
acctgcagt  cttagggct  tggggtcag  tggtggtgg  gagaggcct  ggggctggg  13200
aaggagagt  gactttggc  cactctgcc  tgagaacag  acaccatcc  gcccagccc  13260
gacggggtt  ctcctggtc  aagaggcta  ctgctccaa  gcggagggt  ggagcaggt  13320
tgccagggc  cagggctca  acttgggag  gcctaggca  aagccccaa  ttctgtttt  13380
tgaggtatg  gctgccctt  gcttcagca  gagccttgg  agcagaagg  gaggaacct  13440
ctctgccct  gtccctggg  ggaatcttc  catgtcctt  gccctgcct  gggtgtgtg  13500
tgtgtgctc  tgcatcttg  ctgggagtg  agtgaccgg  accagaacc  tccccacct  13560
aattagggc  tagccatct  cctgtcccc  gcacccctc  ccagcccac  gtggtggcc  13620
ctgcctctt  cctggagag  gaaggacag  gcacggaga  gtttccaga  cacaaattg  13680
tggttccta  cacaaatta  atggtttgg  gcacaatgg  gaagcacac  cccctccct  13740
ctcacctgg  gtccaatgt  ctgtctagt  gcagctttt  ccctggaac  ggggtccct  13800
gagttcaca  gcttatccc  aggaagcct  actcctggg  aaagacaga  aatttcact  13860
cccctttga  ccaccactc  ctctcctta  tacacaagc  cagccgccc  gtgtgcaca  13920
catgtgcag  caccttgga  acctttccc  agccttcct  gcccacagt  gccagtgcc  13980
taggcagtg  tgtggacag  agaggctgc  aaaggcaag  gctggtctt  aggatggag  14040
ccagcctgt  cagaaggct  cagctgaca  cagcgaccc  acctgccat  accttcagg  14100
cctcctctg  aagagaacc  attctcaga  tgcagccag  gaggaacct  acccaagag  14160
aaatgtctg  agagagatg  atggatgga  ggatagatg  atggatggg  tggggagtg  14220
gggtggatg  atggataga  ggatggatg  atggatgga  gggttgggg  gtgggggtg  14280
atggataga  ggatggatg  atggacgga  ggggtgggg  aaggaagga  aggagggag  14340
aaggaggga  tactggctc  atctttgag  gctctggtg  gcagggcag  aacaggcca  14400
agtgctcaa  ccggacacc  tcacgaagg  tcgcaagtc  ctcttgtgg  tcagattgc  14460
cttaggacc  ggagggaca  accagaatc  gggtcccct  ctttacccc  gagttcctt  14520
ctgttcccc  aagcctggg  gcagtctat  ccccaaccc  gccatctcc  ttactcatc  14580
ctcttccac  gcttcccct  tctagcccc  tctgcccta  ctgtctttc  tgagtgttt  14640
aggggagag  gagacccac  tctccccaa  gagatgagc  tttggggca  aacatccca  14700
cgcagtccc  ctcacccga  aacacctcc  acctggccc  ttgccaaat  ccaagcaga  14760
ttagcaaca  gaaaagcag  gccccagga  agacactct  ctatatata  tcttctata  14820
attctgttt  tattgtata  tcactctgt  catgtgggt  taaatgctg  taaatgaca  14880
acccaatat  atactgtgg  tggtggact  ttttcatcc  cagtgctgt  cagatctat  14940
ttcattgta  atttgatat  tttttaatt  tgtagcgtg  ggctgggcc  ggccccagc  15000
ggaggggct  agctggggc  gtgtgcttg  taggtgtgg  cgcgctagt  ctcgttgta  15060
ccttttgct  tgtcttcgc  gtgtgttag  cgtagggcc  agagctcgg  gtgtgtgtg  15120
gcgtgctgt  tgtatggtg  gcacatacg  gagtgtggg  gtgtgtagc  tgctgatct  15180
tgactccca  tgttcacca  cttcctgaa  accacgctc  ctccccctg  ctcctcctc  15240
tcctcttgg  tctattggg  gcctcaggg  cggcagggt  cttcgggag  cccctgcta  15300
ggggaaagg  atgtgtttc  tgctggtga  tcattgcct  cacaccact  ggtttgcca  15360
aaacaggga  ggagggcgt  aagggaaaa  aaaaatcct  aaatttatt  accagtcag  15420
ttcttgctg  tcccagtag  atcgctagc  cttctccag  ggaaaagta  taggattct  15480
aagatggcg  gaccccaag  gggatctca  agcactgct  catttgccg  tgacgcagt  15540
ctgacagtg  ttgaaaagg  ccgcctgcc  cctccccac  gtgcttttg  tgcctttgg  15600
gtcaaaggc  ggtggggtc  cctgatgag  taagatcca  ccccagaat  ctggaggag  15660
aggaggtag  aggagagga  caggtcccc  agtcccttc  cagggtccc  acccccact  15720
gctttggtg  tgtccacac  gtgcccacc  gaaggcaga  ggaactcca  ggcagggat  15780
tgcctgaaa  agtcaacag  cccctgatc  cctacctct  cctgccctc  agccccatc  15840
ccagcttct  gctcaggga  acttccgcc  tcctcactg  ggcaacatg  agcccgagg  15900
ccagatggg  gctgaacag  tagggcaca  cagttaatg  cagtgaggt  agcttctgc  15960
ctccagcaa  acatgtgca  gggttgctg  tttcccagt  ccaggagaa  ccccgctcc  16020
agtcagcct  tgtgggtca  gaggctggg  cccaggaga  acggtccca  gcactgcac  16080
ggcctgcag  attaccagg  ggaggggct  cttttctgc  cttcctcac  cccacgccc  16140
accccactc  cccagagta  tccccactg  gaaaagagc  ggaaactaa  ctggttaga  16200
tgaacctgg  tccctgagc  tccctggat  cttcaaata  gccctgaga  gtgaggtct  16260
ctgcttcac  ggggcccga  gactttggc  gggggaggg  gcctagggc  tcttctcat  16320
gaaagctct  ctttataca  acccaagca  acacaccag  ccgtcactt  gggttctgg  16380
ataagttca  aacaattca  gtccatgtg  cccatggct  gtcagagcc  tgggtcaaa  16440
ccactcagc  caggggagg  gatgaggca  tgtcaccct  gacccctct  cctctctcc  16500
ccaccatag  gtgcaataa  gtgtctgtt  ttaccaaac  cttcttgcc  ttctcacct  16560
ctcttgcaa  gagggagag  gaagggtgg  caaggatcc  gcgggaagc  ttggggtga  16620
aagcttgga  tgggatggg  ggacaggac  gctgagggg  gttgtgggt  ctggctggc  16680
gaggagcag  gcggggagt  tgcacaggt  catatctgt  ttttcctat  aattgtcct  16740
ggtattaac  atgcacaca  ttgtagagg  ccctattgg  gtccagcga  tccacatgt  16800
taatttcct  tcatctttg  aaccgtttc  taagggaga  cctttgctg  ctacatttt  16860
ccaggtgaa  ctgcatctg  aattaggat  gtatttggt  gtctcttac  ggaccctgt  16920
ggggaaact  ctgtcccac  tgactacca  gaaaagcta  acttgtcag  ctggcaagg  16980
tggggtgtg  ggaggccca  ctcagggaa  gacaggggt  ggaaggtgc  agtgttgag  17040
ggtctgaca  caaggacca  gactctctt  ggtgctggg  tgggggggg  gtgggctcc  17100
ctggaacag  catattcta  agttctgcc  ctctcttca  gatagctat  cctcttgca  17160
acttcagta  aaggtaaag  cgaactagg  gatctgaca  cacctctgt  ctaacattc  17220
agccccaag  attcattta  taaacaccc  ctgaatact  agcactgtg  agaacggac  17280
gtgctggtg  ctgggaagc  cttcttcct  cctcaccct  taggagcac  gacattgaa  17340
gaaacaaga  gtctggctc  tggaggagg  ctcaccccc  ccccaccca  ctccaggct  17400
gaatgatgc  gcttgcact  agacgcaca  agccaagga  cctgaagga  cctgccatt  17460
tcttctctt  ccatagaaa  tgttgttcc  ggaatagcc  ccagatggc  ggaaaacct  17520
tctcgccag  tcatagtct  cttgccttc  tctctgtca  ttattcctt  gtgggttag  17580
ttatttgtt  aacaaacat  tattacgta  ccaccctgg  caggctcca  gccagctat  17640
gatgaataa  gataaaatc  gcccctgct  tcctgagtt  ggcagaggg  ggggaccgg  17700
cctataact  cacatctcc  catgtatct  tcaaaccag  aaatggcct  gtgctgaaa  17760
tcactcctt  tcaagtatt  agtcttttg  ttgaaggta  tgtttttgg  tgagatgca  17820
gccctcttg  caggagggg  acacagatc  accaagatg  agcataaca  gggctttgg  17880
tccaaggag  tctagagtc  tacttctca  gttcaagtt  aaatgccac  cagcttcct  17940
cttcctggg  ggccttgag  gagtcattt  atcgctctg  gcttaaatg  cctagtctg  18000
aaaacagac  taataaata  attcaatga  ataacacat  ttggtccag  tatctattg  18060
tgtgttcca  gttactcca  gtctgagcg  cttaaaaca  ccattctat  tcgcagttt  18120
ctgagtaag  aattcaggc  ggactcgtc  gagcaactc  tctggtggc  accaaggtc  18180
ctcagtgat  ttcaactag  agcgaacta  tctggaggg  ccaaggcag  tgccctcac  18240
ttcactcaa  tgccgggca  tccagtgag  atggctgga  gactgagtt  agctgggcc  18300
gccggccag  gtgagcacc  acaactgcc  ctccagcat  gctacttgg  cagacttct  18360
actgaaggg  ttagggtcc  cagagagac  atttcaaga  acaggaggt  gaagctgcc  18420
ggtttttaa  gcctggggc  ggaaaatgg  acagtacct  taccatctt  tgtgggtca  18480
agcatctgc  caaataaag  ggagggcac  cagaagccc  ccttgttga  ggggagtgg  18540
gagagtctg  ctgcccatg  aatgggctg  ttctagagt  ttagggatc  ttgtcatca  18600
tcacctgca  atgcatgga  gccttctcc  gaggggatg  cagcttaga  acacagaac  18660
gggacacac  gcaggtcat  tctggtggg  aggtgagtg  ttaagtttg  gccctgggt  18720
gagggagca  tcagaggag  atgagaagg  catgcagga  gacaggtga  gccactgct  18780
ctgcctcag  tttgcccca  ggcaggtgg  atgagtggt  tgaatcatg  gtctgtcgc  18840
aaccatacc  ccttgggga  gccacttta  ccctggaat  tccattttc  gatctgtaa  18900
aggaggacg  caataaaat  tcttcctta  agatggtat  agggaaaaa  gaacttcat  18960
agtaacatc  actggaata  agtatcgac  tctttccat  tggggatac  ataggtgct  19020
attaaatat  tccttcctt  cttcttgcg  tcctgggca  ggccatggg  cctacttca  19080
tctgggggc  ccatcaccc  tgcaatgag  catctccta  agctattca  aaaggacag  19140
ttcagccta  aatccagag  agccaagga  ggaaggcag  aaaggaact  tctccagga  19200
agggagtac  agagtgtgg  ggtctcact  atcctgtac  ttatcatgt  caccccagc  19260
gtcaccacc  gacagctcc  gtcataggg  cttgggcca  ggctaaagt  ttccacaga  19320
cacaaggct  ttgtggggt  ttgtttttg  tttctttgt  gttggttgg  cccaaattc  19380
ttttaatac  tctcccatc  aaagtggag  ctatgctcc  cctcttgaa  ctgggtgag  19440
aaatgcttc  tgtgaccaa  agggtatag  agaagtgat  ctatgtgac  tccaaggct  19500
gattaggaa  ggccgtgcc  cttccacct  gtgttctag  gatactcat  ctagaggca  19560
ccagctgcc  tgtaagaca  ccaaccacc  tgagactgc  atgctaggg  ggcgatatg  19620
ttgcagatg  ttaggttga  agcttcagc  gagcttcca  ccaacagcc  gtgtcaact  19680
ccagccaca  gaacacagc  tactgaacg  ttagcccag  tgagcttca  atgtttgca  19740
cccgctgac  tctgattgt  gctgcataa  agaccctaa  caagaactg  tcaactgag  19800
ccttcctta  ttcctgacc  ataaaataa  aaacaaaat  aaatggctg  tgggtttat  19860
tcactacat  ctaggggta  tttgtttca  aacaatagt  accagaata  gaaccttag  19920
gattatctg  tcaaacctc  ttgtacaac  atgggggaa  cggaggccc  aagaggaaa  19980
gaccagact  cccacaacc  agcaagggg  agatcgggg  caatgcctg  gtttcttga  20040
tcccaatct  gtgcactct  tgccacaca  caagaaact  acagggagg  ctcctcccc  20100
gccaccccc  gcctcatta  ttccatgca  caagcaagc  tgaatcagg  attttgagt  20160
cctgggatt  tgctgagca  tgggaatat  caaaggacc  ggcaagagt  cctggctcg  20220
agaggcagt  acaatctga  ttgggcatc  cccttcctg  cacactcac  ggtgccagg  20280
acgctgctg  attctttaa  tacatcatc  taggtggga  gaaaccttg  gatgggaga  20340
gactatgcc  gtcattcaa  cacaaaccc  tacaaagat  gatccatgc  aggcacagt  20400
ctggctgca  agcataaag  ctcagtggg  atctgctct  tgtccctgg  tctgagctg  20460
ctgggttct  ggtccctcc  ttctgccca  ggctgaccc  agcagggaa  aatccctgg  20520
cttcaggag  acccaagag  aacctgagt  tggcctgtc  ctccagaca  ctgcttccc  20580
tttccccag  atattgctg  aggggactg  gcccatcag  actaattaa  tcctctaat  20640
gaatgaacc  gtttttcct  gaacttagc  caggtggga  caatctcta  ttttctaga  20700
ggagaaatg  taagtgtca  gaggtcttg  cagccggac  ctgggctag  gtgcatgtg  20760
caggcgcgg  ggcgggagt  tgctgtctg  atgcaggct  agttcccag  ccaggagcc  20820
taaacaagg  ggcctctag  gtccactca  ctggtggcc  ccgtatcgt  ctctgtcct  20880
ggcccaaca  cagccctag  tccgtctct  agagttcgc  gctgctgct  aggcctgac  20940
tccctaagc  gggggaagg  gtccatgag  taacactca  gtcccctcc  accctatga  21000
tccaggtcc  tagtgtatg  ggccctgag  cctgcccag  cccgagctt  tgatctctt  21060
tctttaaga  ctgggcctt  aaaggccac  tttgagccc  agatacaac  tcactggga  21120
taccacagc  acccaaccc  gctttcagt  ctgaggcag  gccattcta  tgatcttca  21180
aagacctga  ttactaggg  taggttctc  ccagagccc  tcccccacc  acccccctc  21240
ccccaaaga  ggctctcac  tttgatttg  agcctgcaa  tctctgcag  ctgcttggg  21300
ttgggggag  caggatgaa  tgagctgag  cgcagacag  aggctgcca  cctgctctt  21360
ccttccctt  tcttgttcc  ccatgagcg  ggaggccct  tcaccctct  atgagtctg  21420
taaagcaat  caattttcc  ggctgggag  gagtgaggc  tgctgggaa  ggatgctgg  21480
tccttggcc  ggacctgaa  gagggtcag  ccctggcag  agctagaat  ccaaaaagg  21540
aaagtgtga  caccaatgg  tagaacctt  ccttggcct  gagcccctc  ccacaaaca  21600
gtttcaaag  aggaagatg  agaggagat  ggatggctc  agtcatcct  aagaggctg  21660
gcccataca  agctcccag  ggggaaagg  gaagggtaa  cggctttga  ttcaggctt  21720
cagcttcct  cggacaggg  cagcgtcgg  actcagagg  tgaggacct  attatgcgg  21780
tggaggggg  gcctggaaa  ggtgcaggt  cttgacagc  tccatcggt  cccctttag  21840
atctcccat  gccctctct  cctattctt  caccacacc  tcacccctg  tgagggaaa  21900
ccgctgtgg  tgacacctt  tgtgaactg  ctttcagac  ggtgctctt  cctgacagc  21960
tgaagaagc  agggcacta  ggagaggac  aaagagaaa  ggtgaaaat  agggaaaga  22020
gcttgggga  ctaggaatt  ccaatagtg  ctgctttgt  gtcttgctt  agcctgtca  22080
gtatcaagg  cttggagga  tgaagaagg  agggagtag  cagagtccc  atggcagag  22140
taggctaga  gatgtacct  aggtcctgg  atcaacagg  agcccagaa  cagctgcca  22200
cccatctgc  cacatcaca  cccccagag  tcagggcga  gtctggagc  aggatgttc  22260
agcaccacc  gagggcagc  ccctcacat  catggtagg  tgtgtcaca  tagcctggg  22320
agggggctc  cctatcctt  cccggctct  tgttttgag  gaacaccaa  acctcacac  22380
aagaaatga  ggggacaag  cccatagtg  taactgcag  atatcgact  cctcagaga  22440
gtacacgta  caggtgagc  cagagttct  gaataaacc  tcagcaagg  tgaggcatt  22500
tctggaggc  tcaggactg  ggctgagct  ccctctccc  agctggtca  tgcacagag  22560
tgggagtcc  ggccccatg  acctttacc  agctgcctc  ctcaggctg  gccctctgt  22620
tttgtcagc  cttcctagg  tcctatgcc  gtgtcccaa  tttctgatc  tcctccctt  22680
cctcttggc  tcctttttc  ctggcagct  tctcccttt  cccatctcc  caggtgctc  22740
tcactatcc  caagcaccg  agagtggaa  caccagttg  gcagattta  taggatgag  22800
ggctgtttt  ttcactgat  tatttccag  acccggaac  gcttctggc  tatcgtagg  22860
attcaataa  tgttcattg  gttaataag  caatcaggg  tgggatact  tgggttttg  22920
ccccttgcc  actacactc  ctttgttac  attactgag  tcagtcatc  tgatgaacg  22980
aaagcaggg  agagacccc  agggacttt  ccaggacac  gaccagata  gacttgaaa  23040
ttattcatt  cattaatat  ctgtggttc  ttcttcctc  ctccagttt  tggcctgtc  23100
cgggtcttc  cttcccagt  acacttggg  tatttcttt  cactgcagc  aactcaaag  23160
cagctaaac  ctgaaatac  aacatcagt  tcgaggagc  gggactggg  acaaagggg  23220
tgccagtaa  tgtgtgttt  tgattaact  acctcccct  cgtgtcagt  cagatcatc  23280
aagatcatt  tcattttgg  tttctggcc  cattaataa  gagactttt  cttgtaaaa  23340
tcccttgca  tggcactga  cttttaacc  ttcctgaga  acacatagg  ccttgtctt  23400
tttttctca  ttgagctag  tactgcctg  tctggaact  ggaaggtgc  caggtgtcc  23460
gggcaggtg  gtcattcac  tttcatttc  gcctcaaga  ctctttaca  catccagac  23520
ggcatggag  ctgcctgaa  ctgtaaaaa  gaaaaaaaa  cccaatggg  attaatatg  23580
agatgtaaa  taggttctg  acttaacaa  aacaaatga  tctggaaat  gctcttggg  23640
tagggccag  aaagtcctg  tggtgccta  gttttgggt  tggcagctt  tcaatcact  23700
agcaaacag  ttctcagag  caggcactg  gggagctat  aagatgaaa  agcacaatg  23760
cgcctgcag  agctcaggg  tagggaggg  agaggagac  tatacacag  caaagtcaa  23820
ttgtaatgg  tagaataag  gtagaaaca  gaaggggtc  tgaggcagg  cacgggcat  23880
tcctatgtg  accccagag  aatgacgag  aaaggcttt  actaatgac  tttcagggc  23940
acccaccca  tccacatcc  taaaacatt  cgcgatgaa  acagccaga  ctacggttt  24000
cttccatcc  gcacaagaa  cgcttctct  cccaaggcc  ccccgtcct  cattccatc  24060
cggggactt  ggtggctgg  acagaggcg  agagcatca  gaccatggg  gtcttgggc  24120
acgttgggc  tccgaggcg  aggatgcgg  gcggggtgg  cagaaggcc  caacacggt  24180
cctgggaaa  gagagggca  cctgatcct  gcgacagcg  ctctaccct  tttcttcct  24240
ggccttccg  cagccgcag  gaaacggca  cagtgcgac  agcttggcg  ggagggggc  24300
agggacgaa  caagaagag  cgggcggag  ttagaggtc  ggggtcgag  gcgcttcgg  24360
gtcagcggg  tgcggtggg  ggagctgcg  gcccggggg  ggcgcggag  agggctgag  24420
ggggcggga  gggttgccg  cggaagcgc  caggggcgg  gcgctgggc  gggcactgg  24480
ggcgaggag  tgacgcgct  ggttggggc  cggctccgg  gaggaagac  gcgctcggt  24540
gccagggcc  gcagtgagt  ggatcggcc  cgcgctgcg  cgcgccccg  ccaccccgc  24600
ccgcgaagg  cgcgtctgg  cgaggcggg  ccccggagg  aaaggcgcc  ctggggcgt  24660
gcggccgct  ccagcgccg  agggagacc  tgagcccct  gggccccag  ccaccggcg  24720
cgaggcgcc  cctccccta  gccacctcg  gcccgcccc  tgccgcgcg  gagccaagg  24780
cggcgcccc  cccggagat  ggcagacgc  tagatggcg  ggctcccag  gccgccaga  24840
cgcaggaac  aggcgccgg  gcgttgcgc  gaggctccc  ctccgcgcg  cccgggaag  24900
ctgcaggtg  ccttggccg  tcggccgcc  cccccggta  accttcgcc  gtgcccaga  24960
cccggctcc  cagagcggc  ccgcccccc  ggctcggcg  cgcgcagga  gccccgtct  25020
aggcacccc  gccccagcg  ggcccccgc  gcgctgcgc  cggtccggc  cagctccca  25080
ccgcggacg  aggacccga  gctcgctcc  gcgggcgcg  ttgttttcc  gctgccgcc  25140
cgccctgcg  agcccccgc  cgcccggcc  ccgctctct  ctctgcccc  cctgccttc  25200
tcgcccggc  ctggattta  gaatggggg  aagaggcca  atgccgccg  cgccgcctc  25260
tgttgaccg  aagcagccc  ggcccacgg  gctccggct  ccgtgagag  gtcggcctg  25320
ccccggcag  cgctcggag  acttgttgc  gctgcgctg  cgccgctgc  gggaagccg  25380
ctattccgg  gcttggtgc  gtcttggag  cggagggtg  cccgtgtga  cgcgagcgc  25440
ccggacctt  gcggtgcgc  tggactgtg  gcttcctcg  ctttggtcg  ggtgaaggc  25500
ggggcgtgt  cccggccca  agcgtttgt  tgtcccgtc  tagcggggg  ccgcgtgtg  25560
gcttgcttc  acttccccg  gtcctccct  tctgcgcct  cctctctcc  gagcttcct  25620
ccctaaccc  aaccacctg  gtaccggag  aatccaact  ctcccgctc  gcgtcctag  25680
gggataggc  ggggcaagc  caagccgca  agggggccg  caccgcctc  tgcctcctc  25740
tcgtctcct  cccctcccc  gtctgacgc  gcctcctcg  gaagggtgt  tggagggca  25800
cggccgccc  aagccggag  cccgcagcg  ttcttatga  cagctcggt  tgtgtctcc  25860
cctaccgcg  gcgcaagtc  gggaacaag  ctccgtcca  aacatgtct  aaggaggag  25920
tggccaagg  cgaggcgtc  gagaagatc  tcatcaacg  gggcggcac  cgacatgag  25980
cctaccgca  caccctgcg  accctaccg  gaacccgcc  cgcctggct  gccgacccc  26040
acggcgggg  ccggcccga  accgatggc  gcggtgtgg  tagcagcgg  agcagcggc  26100
gcgggggct  cgagttctt  ttcgacagg  acccgggcg  cttcgccta  gtgctcaac  26160
actaccgca  cggcaagct  cactgcccc  cggacgtgt  cgggccgct  ttcgaagag  26220
agctcacct  ctggggcat  gacgagacc  acgtggaac  ctgctgctg  atgacctac  26280
ggcagcacc  cgacgccga  gaggcgctc  acatcttcg  gagcccgga  ggaggcggc  26340
gcggcgcgg  gcccagcga  gaggccggc  acgatgagc  ggagctggc  ctgcagcga  26400
tgggccccc  cgagggagg  gcgggccat  gcgccgggt  tgggggctg  cgcggctgg  26460
agccccgca  gtgggcgct  ttcgaggat  cctactcct  ccgggccgc  agggtgagt  26520
gcaggagcc  gtgtctccc  atcttgggt  tgcaagggg  ccgtggtgg  tggtgggta  26580
gggccggga  gagcaggga  cgagcctga  ttaccttac  accgcagat  gttcccgcc  26640
tcctctcaa  ccccctccg  ggctcgcag  ggaattaca  actcccacc  tctcccctg  26700
acgctccat  aggagattg  acacacttg  cttactact  ggacccagt  ccagctgcc  26760
gctttgccg  atcccctcc  gtgagtggg  tgcccagct  agctcctcc  cccccttct  26820
tggtctgca  aggctgccc  atcttcagc  gccctccac  ccacacagg  ctacggtcc  26880
ggaagagct  gaatttggt  ttctgatgg  ggcaggcag  gttgagagg  aggaaacta  26940
ggtgggttt  gttagatgc  tccatgccg  gccacctca  ttacatcct  ccagcagct  27000
agtgtgctc  caactatgc  cttcagaga  gaggatata  gcttcagca  cttaagctc  27060
gaagaggca  agctgagac  acaatccgg  ctcctttcc  ggtttaaga  aggcattct  27120
tctgccagg  aggatacca  gcccctgag  cttcctgca  acctgggat  tcctggcct  27180
agctggggt  agaggagaa  taaacacga  gggcctagc  ttctaggct  tgcaggctc  27240
cacggccag  ggccagcca  aggcttcct  gtgatgata  cagattttt  ttgccgctt  27300
ttttctttc  gctgcagca  aaactgtct  tccagaaag  cctggttca  gttactgct  27360
gaaatgggt  tatgaggga  gggggaagc  caggttgat  taggcaaga  ctaccgcct  27420
ctccccaag  aaatccagt  tccctaact  ctttaggtg  aaggggaga  cgggggagg  27480
gcttccccc  ttatgcttc  acagctaaa  aaaaaaaaa  aaaaaaaaa  aaatccctg  27540
aggatggct  tagattctt  aaagaaaga  aactctggg  gctggtgtc  gatctcatg  27600
tcagcagcc  aaagcctgg  tggagtctg  ctgggagac  ggaaagagc  atgtaactt  27660
ttgggtctg  ggactgctg  ttgctgtgg  acctggttg  ttcctccag  atcccaaat  27720
gtcatgtta  tgagtctca  agcaccctc  ctttcccag  acccctgtg  tggactcct  27780
cctagtcat  gaagaaggc  gggtaggga  ttggggaac  ggcctgcag  gaaaagcca  27840
gctggcata  atgccaggc  agggcagat  catcttctg  ctggaagag  agggaggag  27900
agaggtctc  ggggccatg  cataccggg  tggggctgc  ggcagccac  agaaggcag  27960
gatctttct  aggactgac  acaaagcta  aggcaactg  ctgggtttc  ttccttgca  28020
ccctgagac  ggctaagaa  gtgagggca  agtgatgcc  ctggcctgg  tctgctgtg  28080
gttctacag  cttctcatg  aggtcacta  ccttgctag  gttagcact  ggctgtctg  28140
attagggga  agagggcag  cacacatca  tcagactct  tcaaagttg  gggtcgggg  28200
ggagagata  agatagaga  ggggaaagg  gacaaacca  ggaagcagg  atgagatga  28260
gtggttagg  gagctaggc  ctatttctg  gcattctgg  acttctagg  gcttttcac  28320
tgctcttct  cccctctgg  attccaggt  gcaccccac  tatcattga  tttattttc  28380
tcctaactc  ctgctgaat  gccaagcca  ggggcctct  tgagtaagc  cagagcctg  28440
cctgcccct  gaagtcttc  caggaaccc  gggtgcttt  cccctttga  atggaatca  28500
atcagccca  gcattccag  tgaggtctt  aagtttatg  tggagcaag  ttaattctt  28560
catttaaac  ttgagaaaa  caggattca  agacattaa  tttcttgcc  aagacattt  28620
actaatagc  gaggcagga  accacccct  gtttccagc  ttctggttg  tcatcctga  28680
gtgaatatc  ggatggagc  ctggccaac  catgcacta  aagaggact  gcctcctgc  28740
caggagccc  ggcaaaggc  accctcacc  gctcccggg  cacacaagt  ggaatacat  28800
atttttaca  attaatgaa  aactgctca  tattgagca  cccagacag  tacattgct  28860
tatatactt  acattaatc  ctaatcctc  caataaact  aaaacccgg  gattatccc  28920
gtttaatag  ttgaggctg  gagaaggta  acaacttgc  tgagatcac  cagccagat  28980
gtggccagg  tttgaatca  agccagagt  cctgactcc  aagcccttg  tcttgtgat  29040
acaacacct  ctttccact  aactaggct  tttttgagg  agagagctt  tttcttact  29100
tagcctgag  aatgtcctt  tgaggttct  tacctcctg  ggatgacat  agaaaaccc  29160
ggggcagat  gagacgtca  aaggaagac  tactgtatt  cccctccag  cctgagggt  29220
ctatgccat  cggggagtt  tggggctgc  ctttccccc  tccatttgc  cctggcttg  29280
cacactgtc  catccttcc  agccctgtt  cccccggta  atgtgctac  ttccctcgc  29340
cacagctac  tcctccctg  aagggcccg  agcactgtg  ggtggtggg  gaagaggga  29400
agaggagca  tgctctgcc  tgaggcgtc  tttcgcaca  agcaacctg  tcatttgag  29460
agtgcgtta  gacaggagc  aaacgatac  aatggaaag  gaactgagc  gattatgag  29520
gcctgttgc  tagctacag  cctggccca  ggagctgtt  cgctcaggc  ggctcctgg  29580
ctgggatgc  cacccctgc  ccactgtgc  gggcccatg  gcagctgct  ctgtggttc  29640
gtttctgtg  cctgagctg  gaacaggta  gaggggcag  gcagagtga  ggctcaccg  29700
ggagacttc  cagcctcag  gggcccagt  gaggtttgg  agcatccga  actttagaa  29760
cctgcacct  cttttctga  agcagacaa  aggcctgga  aatggggcc  ggatgccct  29820
cccctaccc  agtctccaa  gtctccagg  cagggctgg  tttagctca  ctatcagcc  29880
tattaagga  tacagttcc  ctcctttgg  taaatcagc  catttttcc  gtgatgttt  29940
ccttttgag  agaggaggg  acccacagg  actccctgc  ccaggaagg  agctccagc  30000
gggtcttcc  ctttgttaa  tgtcagtta  tatgtggga  gcttggcct  tgctttctg  30060
tactactca  ctggcctag  tgaggcaga  attgttaac  tctgtgtat  agtatacag  30120
taaggaaac  ggcctggtg  ggctttctc  aggtcgcac  acttgtggt  gaactagga  30180
ccaaaccta  gtctcatca  tctaagtct  tgctcctcc  atggcctct  gctcctgcc  30240
agagaggat  tctggtttc  agagggtgg  ccctcactg  agagcttct  cctccactc  30300
gctcttatc  gttccttta  ttctcactc  ccagaattg  tcaaggata  cctctcttc  30360
cactgtggg  tttccatag  aaaaatgaa  ggaggcgtg  ctgggagaa  agactaagg  30420
aagctccct  gcccaggca  agcatgaaa  caaggcctt  taggaaagg  gcagagctg  30480
attcctgcc  gcccgcttc  gaagttccc  ggcttctct  gtccgggca  tgcctgggg  30540
acaggtcag  gatcacgac  ggctttaaa  tgagggcca  gactcactg  tgctgtgcc  30600
tctgagcta  ggtgaacca  gaacctgag  ccaggaggg  agtaccctg  ctttctgag  30660
tccccagga  ggcagtgcc  agcctgccc  gggcagccc  tccacctcc  tcctgagga  30720
caggcaggg  ccaggctga  ggctgcagg  ctccctgca  gccctgccc  cagggcatc  30780
tcccagttt  ctcttgggt  tgttttctt  tcttgttct  aacagatca  catttgtct  30840
tgaacatct  gtctctgaa  gctgaggtg  ttctggttg  cacattagg  gtggggtgt  30900
gagtaggga  ggggagaaa  taaacgagc  attttggag  ctcggggga  gagcaggca  30960
gcaggagca  agccaggca  cttggcctt  agggtagga  accctgggc  cttcacccc  31020
acccatggg  agtgtcagc  tgggatgct  ggcaccaga  ctctgtgca  ccctcattc  31080
ctgtgcgta  ctgacttgc  atgacctct  gccctgctc  ctgctggaa  tttcttcag  31140
ctaaggggt  gtcacctgg  ccctagcag  ggtccttat  tggaagtgg  cctggctcg  31200
tctggaggg  agcagaggt  ctagggccc  agcacctag  ggtattact  ggcatatac  31260
cttgtcact  tgtcccagt  agtggagct  atgacctct  cttctgaca  gctcatcag  31320
accaggaga  agagcaggg  gtcaccttg  ccccagtca  tcagaaaac  cttactgcg  31380
acttaccat  cacatgtgg  gttctagaa  tccaaagat  agtcagagg  ggccatgct  31440
ctgacaaaa  ccaagtcgg  tagagtaag  ggcagtcaa  ggaaattag  tgacaagaa  31500
tggcaacag  aatacaaga  ggatcatga  aggtgccac  ggagtcgta  gaaaataaa  31560
ttcaatagg  agtgagagg  ggaatcaat  aatcccacc  ctacgtggg  tgaggtgta  31620
gaggtgttc  gagaggctt  cacaaggaa  tagaagttg  attgggtgg  ccttgtagg  31680
tactgactt  gtgccttaa  taatttttt  aaagagtca  attataaat  catacat  31737



<210> 9809
<211> 606
<212> PRT
<213> Homo sapiens
<308> CAC19684
<400> 9809

Met Ile Ser Ser Val Cys Val Ser Ser Tyr Arg Gly Arg Lys Ser Gly 
  1               5                  10                  15
Asn Lys Pro Pro Ser Lys Thr Cys Leu Lys Glu Glu Met Ala Lys Gly 
             20                  25                  30
Glu Ala Ser Glu Lys Ile Ile Ile Asn Val Gly Gly Thr Arg His Glu 
         35                  40                  45
Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr Arg Leu Ala Trp 
     50                  55                  60
Leu Ala Asp Pro Asp Gly Gly Gly Arg Pro Glu Thr Asp Gly Gly Gly 
 65                  70                  75                  80
Val Gly Ser Ser Gly Ser Ser Gly Gly Gly Gly Cys Glu Phe Phe Phe 
                 85                  90                  95
Asp Arg His Pro Gly Val Phe Ala Tyr Val Leu Asn Tyr Tyr Arg Thr 
             100                105                110
Gly Lys Leu His Cys Pro Ala Asp Val Cys Gly Pro Leu Phe Glu Glu 
         115                120                125
Glu Leu Thr Phe Trp Gly Ile Asp Glu Thr Asp Val Glu Pro Cys Cys 
     130                135                140
Trp Met Thr Tyr Arg Gln His Arg Asp Ala Glu Glu Ala Leu Asp Ile 
 145                150                155                160
Phe Glu Ser Pro Asp Gly Gly Gly Ser Gly Ala Gly Pro Ser Asp Glu 
                 165                170                175
Ala Gly Asp Asp Glu Arg Glu Leu Ala Leu Gln Arg Leu Gly Pro His 
             180                185                190
Glu Gly Gly Ala Gly His Gly Ala Gly Ser Gly Gly Cys Arg Gly Trp 
         195                200                205
Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Ala 
     210                215                220
Ala Arg Val Val Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser Ile 
 225                230                235                240
Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile Asp Arg Asn 
                 245                250                255
Val Thr Glu Ile Leu Arg Val Gly Asn Ile Thr Ser Val His Phe Arg 
             260                265                270
Arg Glu Val Glu Thr Glu Pro Ile Leu Thr Tyr Ile Glu Gly Val Cys 
         275                280                285
Val Leu Trp Phe Thr Leu Glu Phe Leu Val Arg Ile Val Cys Cys Pro 
     290                295                300
Asp Thr Leu Asp Phe Val Lys Asn Leu Leu Asn Ile Ile Asp Phe Val 
 305                310                315                320
Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser Ser 
                 325                330                335
Lys Ala Ala Arg Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe Val 
             340                345                350
Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu Arg 
         355                360                365
Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu Leu 
     370                375                380
Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile Tyr 
 385                390                395                400
Tyr Ala Glu Arg Ile Gly Ala Arg Pro Ser Asp Pro Arg Gly Asn Asp 
                 405                410                415
His Thr Asp Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val Val 
             420                425                430
Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Lys Thr Trp Ser 
         435                440                445
Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr Ile 
     450                455                460
Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr Ser 
 465                470                475                480
Leu Ala Met Ala Lys Gln Lys Leu Pro Lys Lys Arg Lys Lys His Val 
                 485                490                495
Pro Arg Pro Ala Gln Leu Glu Ser Pro Met Tyr Cys Lys Ser Glu Glu 
             500                505                510
Thr Ser Pro Arg Asp Ser Thr Cys Ser Asp Thr Ser Pro Pro Ala Arg 
         515                520                525
Glu Glu Gly Met Ile Glu Arg Lys Arg Ala Asp Ser Lys Gln Asn Gly 
     530                535                540
Asp Ala Asn Ala Val Leu Ser Asp Glu Glu Gly Ala Gly Leu Thr Gln 
 545                550                555                560
Pro Leu Ala Ser Ser Pro Thr Pro Glu Glu Arg Arg Ala Leu Arg Arg 
                 565                570                575
Ser Thr Thr Arg Asp Arg Asn Lys Lys Ala Ala Ala Cys Phe Leu Leu 
             580                585                590
Ser Thr Gly Asp Tyr Ala Cys Ala Asp Gly Ser Val Arg Lys 
         595                600                605



<210> 9811
<211> 638
<212> PRT
<213> Rattus norvegicus
<308> CAA44643
<400> 9811

Met Gly Lys Ile Glu Asn Asn Glu Arg Val Ile Leu Asn Val Gly Gly 
  1               5                  10                  15
Thr Arg His Glu Thr Tyr Arg Ser Thr Leu Lys Thr Leu Pro Gly Thr 
             20                  25                  30
Arg Leu Ala Leu Leu Ala Ser Ser Glu Pro Gln Gly Asp Cys Leu Thr 
         35                  40                  45
Ala Ala Gly Asp Lys Leu Gln Pro Leu Pro Pro Pro Leu Ser Pro Pro 
     50                  55                  60
Pro Arg Pro Pro Pro Leu Ser Pro Val Pro Ser Gly Cys Phe Glu Gly 
 65                  70                  75                  80
Gly Ala Gly Asn Cys Ser Ser His Gly Gly Asn Gly Ser Asp His Pro 
                 85                  90                  95
Gly Gly Gly Arg Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe Ala 
             100                105                110
Tyr Val Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala Asp 
         115                120                125
Val Cys Gly Pro Leu Phe Glu Glu Glu Leu Ala Phe Trp Gly Ile Asp 
     130                135                140
Glu Thr Asp Val Glu Pro Cys Cys Trp Met Thr Tyr Arg Gln His Arg 
 145                150                155                160
Asp Ala Glu Glu Ala Leu Asp Ile Phe Glu Thr Pro Asp Leu Ile Gly 
                 165                170                175
Gly Asp Pro Gly Asp Asp Glu Asp Leu Gly Gly Lys Arg Leu Gly Ile 
             180                185                190
Glu Asp Ala Ala Gly Leu Gly Gly Pro Asp Gly Lys Ser Gly Arg Trp 
         195                200                205
Arg Lys Leu Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser 
     210                215                220
Ser Arg Ala Ala Arg Phe Ile Ala Phe Ala Ser Leu Phe Phe Ile Leu 
 225                230                235                240
Val Ser Ile Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile 
                 245                250                255
Val Lys Asn Lys Thr Glu Pro Val Ile Asn Gly Thr Ser Ala Val Leu 
             260                265                270
Gln Tyr Glu Ile Glu Thr Asp Pro Ala Leu Thr Tyr Val Glu Gly Val 
         275                280                285
Cys Val Val Trp Phe Thr Phe Glu Phe Leu Val Arg Ile Val Phe Ser 
     290                295                300
Pro Asn Lys Leu Glu Phe Ile Lys Asn Leu Leu Asn Ile Ile Asp Phe 
 305                310                315                320
Val Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser 
                 325                330                335
Ser Lys Ala Ala Lys Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe 
             340                345                350
Val Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu 
         355                360                365
Arg Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu 
     370                375                380
Leu Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile 
 385                390                395                400
Tyr Tyr Ala Glu Arg Val Gly Ala Gln Pro Asn Asp Pro Ser Ala Ser 
                 405                410                415
Glu His Thr Gln Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val 
             420                425                430
Val Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Gln Thr Trp 
         435                440                445
Ser Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr 
     450                455                460
Ile Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr 
 465                470                475                480
Ser Leu Ala Met Ala Lys Gln Lys Leu Pro Arg Lys Arg Lys Lys His 
                 485                490                495
Ile Pro Pro Ala Pro Leu Ala Ser Ser Pro Thr Phe Cys Lys Thr Glu 
             500                505                510
Leu Asn Met Ala Cys Asn Ser Thr Gln Ser Asp Thr Cys Leu Gly Lys 
         515                520                525
Glu Asn Arg Leu Leu Glu His Asn Arg Ser Val Leu Ser Gly Asp Asp 
     530                535                540
Ser Thr Gly Ser Glu Pro Pro Leu Ser Pro Pro Glu Arg Leu Pro Ile 
 545                550                555                560
Arg Arg Ser Ser Thr Arg Asp Lys Asn Arg Arg Gly Glu Thr Cys Phe 
                 565                570                575
Leu Leu Thr Thr Gly Asp Tyr Thr Cys Ala Ser Asp Gly Gly Ile Arg 
             580                585                590
Lys Gly Tyr Glu Lys Ser Arg Ser Leu Asn Asn Ile Ala Gly Leu Ala 
         595                600                605
Gly Asn Ala Leu Arg Leu Ser Pro Val Thr Ser Pro Tyr Asn Ser Pro 
     610                615                620
Cys Pro Leu Arg Arg Ser Arg Ser Pro Ile Pro Ser Ile Leu 
 625                630                635



<210> 9812
<211> 31737
<212> DNA
<213> Homo sapiens
<308> AL137790
<400> 9812

gatccgagg  ttgcttctc  gaggacctg  ttacccaca  tgcctccat  tcctcccct  3180
tgcctctct  ttttcttca  ttcccctgg  ttcttgcca  ggagcaact  cgaggaagc  3240
tctgaagcc  cctgtggcc  cctgcgtgg  ctccctcag  gtctttcac  ggcagcact  3300
acccttcct  ctccaggct  tgggttttc  tcttgcctc  gctgcttct  cttctctga  3360
tccctttca  gagactctc  ctcttccct  cattcagtg  tggagatag  agcaggctt  3420
tgcttctta  ccctctgta  ctacagcca  agcctcagc  cctgccagc  cacctgcta  3480
tcagaaagt  tatctccag  ttgtctctc  ctggctcca  gctcatctg  ccagcggac  3540
acttggcat  tcattttag  tgtcttaaa  acacattca  ctcaacctt  gtagaacta  3600
tgtcctgat  ctccctgcc  aacaccatc  acctgttcc  ctcccactg  ccccatctc  3660
acctgctca  gtatgcagg  cagagacat  gccctcacc  cggcctctc  ctctccagc  3720
tctcccatc  ccagtccat  ccgaaggtc  ccttggttt  tcctgcgaa  atctctcca  3780
tggcaccac  cagcccctt  gcaaagcca  tgtcccctc  agcctggac  ccagaagcc  3840
cttccttga  ggtctgctg  atccactta  ttcttttgg  aatgcacat  attgtgtcc  3900
cacttcttt  aacccctcg  tggcttctt  ggttaggtg  tttcttagg  tgaagacag  3960
atctgtaca  gcctttgat  taacttctc  cctctccca  ccctacctg  gccaccccc  4020
cctcgtcct  actgcttca  ccaccctgg  accttccat  cccttttac  caccatcct  4080
tgtcctatc  caggacctc  gtccatgct  cttcccgaa  gttcttccc  ccccttgtg  4140
cctcgcttt  atcagcttt  aaatgtcag  ttgaggacc  cttcttctg  gaagccttg  4200
ctggcctcc  aacttgttc  gatcccctt  ttatgggct  tccaagcac  gggtgccca  4260
ccttcacag  ccttgtcac  tttgcaatt  agcatttgt  cgtgggatc  tttgaccaa  4320
gtgtctctc  ccaactaga  tgtaaactt  gagagcctg  ttgcttcta  tccccatgg  4380
ctctgcatc  cctagcacc  ggcctggcc  acagcaggt  ctcagagat  gatggatga  4440
tggctacat  tcattgcca  agggaggcc  tgacacctt  tacctaata  gtacacagg  4500
gtgggctgg  gagagggtc  cctcataga  gccaagggg  ccttagatc  ttaaggcct  4560
ggttctggg  tttcttggt  gactaaaga  ggttttact  attttgtgc  ggatggggg  4620
ccttaatct  ccctggagt  cacatgctg  ctgaccagg  agtcctcct  ggtctccat  4680
tgtgcccag  ccctgaagc  caaaggctc  actaccatc  cccacctct  tcccctcag  4740
atgggggtg  cgccctcag  ctcactgct  tgccagcgc  ctgagcttg  caacatctc  4800
gctgttgga  tgctgccag  agttgagac  tgcctagga  gctgctgag  tgatggcag  4860
tgggccctg  gtcctggat  ttatttagg  ctgtgatat  aaagacagc  aaagtccag  4920
cggacccta  agtccaaca  ctcactgtt  aggtgagga  ttacccaca  gtactcaga  4980
ggggcagcc  ggccaggac  cacacaggg  ttgtcacca  agggaagtg  actctctga  5040
ttggctcct  gcctcctta  tctgtctgg  gtgaggtca  ttaggttca  ctcagcagc  5100
aaggtcaca  gggaaaatg  tttaaagag  ataggtgat  gaaaaactg  gtcaggagt  5160
ggtgctggg  ccgggggcg  gggcctggc  cagaatatc  atattttag  tatcactct  5220
ccccgacta  ccagctcca  taccttgag  aagtcattt  atctttggg  tctcagttt  5280
ccctttaaa  acatgaata  taatccttg  ttcctgcac  cccgcaaaa  acaaaacac  5340
ctgtcctga  gaggtcagc  tcattctgt  gggattgag  gccactacg  acaggcatt  5400
cttgttgct  tacatttga  cctcacgtt  actccgaga  tctattact  ttccctttt  5460
ttcagatga  taatctgaa  ctcataaca  agtcagtgc  acttaccaa  agcttcata  5520
ccatttaaa  atgggagtc  ggatttgga  ctggatctg  ctgagactc  aaagctctg  5580
gctgggtcc  aggcttggt  cctgcccca  ggaacaaac  ataaaagga  aataggttg  5640
aaaggggct  tggaaattg  tccatgcca  cccaatgct  ttgcagttc  ggctcctgt  5700
aggtgtgag  gcagatgga  gcttaggcg  aggcccttt  tccaggaat  gtctaggtt  5760
tgtgcttca  gttgggtga  ggtggggaa  agcaggcgg  ttgggtttt  tttcctttc  5820
tgaggtaga  gagtttgag  tggagaagg  gtcagggag  ttctggtat  ctcagtttt  5880
ttgtgctgc  gtgcaagct  ttcactgca  gactctagg  ggcacctgt  acactgtag  5940
ccaagtgaa  ggcactctc  agagctgtg  actacatga  catatgtga  ggccttgac  6000
atgttcctt  gtatgatgg  tgcatggga  gccatggta  cagttaaat  actatgtaa  6060
cactcagca  ttatgttgt  ttaccaagt  ctcacagtc  tcctctgaa  ttgatactc  6120
tgtgatctg  gtattgggg  aactgaggc  cagaggagt  gggaaattg  ccaagttca  6180
acagcttct  accactatg  gctgctgcc  ctgaactct  ttgaggctg  gaaaggggg  6240
gtgcacatg  ataaaacca  cccctctgt  tctcttttc  tcctcctgc  ttggtcttc  6300
gccatagct  gacaagatg  tggaccccc  ggtgtggcg  gaggcagct  cccaggtct  6360
ctttgcctt  ggcctgggc  ttggtggtg  cattgcctt  tccagctac  ataagcagg  6420
caacaactg  cacttcgat  ccgccctgg  gtccttcat  aacttcttc  cgtcagtgt  6480
ggccaccct  gtggtgttt  ctgtgctgg  cttcaaggc  aacatcatg  atgagaagt  6540
tgtggtcga  taggtggca  ctctcctcc  gtccctcct  ctccctgtc  accttacct  6600
ggagtgggc  ggggtgggg  cgcaggtgt  catggggag  gaggtcccc  ccactcaga  6660
tgaggaatg  agatcagag  agcactctc  gtccccagc  ccgggccac  gggacaagc  6720
cagagatgc  tctgtcagt  acccatgag  ttcccacct  ggtgcctgg  aagagcctc  6780
aggatctca  ccattgccc  cccctgcct  cttacctgg  cctctcggt  ttgtgctgc  6840
ggaatgctg  gaaaatcct  gggtacctt  acaccaacg  cctgagccg  gacctcatc  6900
caccccacg  caacttctc  cacctgacc  caaaggact  catggagat  tacaatgtc  6960
tcatgaccg  gaaggagga  cagttctca  ccctgggcc  tgacccctg  cttctggag  7020
acgagctgg  caaggtgcg  ggacaggct  cccttccca  gacaggcag  aacccagag  7080
gcagctgtg  ccggcggga  cttgggctc  ggcctcagg  tgctgacag  tagtcatta  7140
tttacttgg  aagcaagga  ctgctgtgt  tccagaggg  gtgaaaggg  agaaaggta  7200
tggccaaag  ccctgccca  aggtaggct  gagcctaga  aagaagtag  gcagacaca  7260
acctctcag  agtcacagt  agtgtatgg  acgatgttt  catttactg  gtgggcttc  7320
cgtgcatca  tcactgcca  aggtaatat  ctcagaaca  tgccttgac  tggtgtgca  7380
caaagaagt  ttgaagtta  tgtttgccc  ttgctgtct  tctcttttg  cgctcaaga  7440
agctctatg  gttgagtat  catattgtt  cctacctta  agatgagta  cctatgaga  7500
ggggggctt  atcaaggtc  cataactag  aagtcagag  ggcagttag  tgggtccaa  7560
tccagttag  tgggtccag  gcccatgct  aggatcacc  cttgatgct  ctgcccctc  7620
ccaacctgt  cccattcca  tctcactgc  atgatgact  ttagacttt  gggtggtgc  7680
gggggtgct  actcctcct  agtgctcag  cccatgtta  gacaccttg  ttctattta  7740
acttacata  ctggacact  tcaaaatga  tgttctgtt  gaaggggta  caggaaagg  7800
acataccca  agcatcttg  gaaccaggc  ggagccaag  ctcacatgg  gcggagcca  7860
ctcccatca  cctgggtca  ccctgtcct  catgggact  gggaagggg  tgctttccc  7920
gggctctat  ttaaaagtc  gctccattg  atggtacca  cctaatgct  agggagctg  7980
atcctacac  ccaaccctt  ccctgcgga  caagagcaa  agagcccaa  ctcgggccc  8040
ctgccctgg  ttcttcccc  ggtaactgg  agcataaag  acctcccct  ttcacattc  8100
ctgaaaccc  gctcagttc  catgggcat  gcctggttc  ctgaattaa  ctaggttta  8160
agcagtgtt  tcatacaat  caactccga  agcattcaa  tgacaagat  atacactca  8220
ttagtgggg  agaaatgtt  ccttacaat  actgaacat  acagggcaa  gtgtaagtg  8280
cagggggca  tgtgtggtc  cctgaccca  aagcatggc  caagcatta  agcagtgat  8340
ctctacctt  gctacccat  agagttcct  gggtatttt  gtttgtttt  aaaaaaaac  8400
ctgacaccc  gcttcaccc  agaccaatc  agtcattgt  cgtggggtg  gacccaggt  8460
tcggtgttt  taaaggctc  ggtgtgctt  cattgagag  cgaggctga  accactgca  8520
gaagatctg  agttcagaa  ttctgagct  ggagcggcc  cagtgtggc  ggagcaatc  8580
ggaaagaca  cttagagga  cagggtcct  agctgggtg  atttctaaa  atgagcatc  8640
tcacttgaa  cacctaagc  cctggtaca  cccgtagat  ccaggtccc  caggtgaac  8700
cccaagttg  tgtttttga  ctacgtcta  gggattcca  tgcctgcta  agttcgaga  8760
ccactggcc  aaatcaaca  gatttaggt  gaggtggga  cccctgtga  agagggaat  8820
gttattcca  aagtttgaa  ggcagaggg  aggaagcag  gggctcccc  gggaggggt  8880
acctcacag  ccctgcttt  caccccacc  tcagtccgt  cagggcaca  gcctggcct  8940
catcgcctt  actgaggcc  tgacgcact  ccccgcctc  ccgttctgg  ccgtcatgt  9000
cttcttgat  cttatcaac  tgggcctgg  cagcatgat  gggaccatg  caggcatca  9060
cacgcccat  atcgacacc  tcaaggtgc  caaggagat  ttcacaggt  actcctccc  9120
gcccccatg  ccaggctct  caggctgcc  ttgtggaca  caattccgt  ctggcttct  9180
actgggtcc  tcatgaccc  acacccaga  ggctccacc  cacactggg  cacagctgg  9240
gcctggctg  gccactcag  gattagcac  cacaagcca  gaagagaaa  ctacttgga  9300
atctggagc  aacatgagc  gggaggcct  catctaggc  cctttgtta  ttcacttgc  9360
cctctcccc  agggcctgc  gagtcgtct  gggaagtgg  tgctgagtc  tcttgggca  9420
gggcactca  tggccttgc  ccctgttcc  tctttgtca  tccagtccc  ggctgtgtc  9480
acagttccc  tcggggttt  ctgcgttga  ctagggccc  tagagggat  cctctcatc  9540
gcatcccta  agcggggta  ctttctgtt  tcaagtggg  aaactgagg  ggagaaaaa  9600
actggtaac  atcagatga  tcatttaag  taaatacag  aattaagta  cgcacctgc  9660
acgggccag  ccctgtgct  gggcagagg  atgggatga  agttagaca  aacgccttc  9720
tcaggtgct  cccgactag  agagcgggg  tcagaacct  agcatctgg  tccctcgtg  9780
aggactgag  ctgctggca  gagggctgc  ggcatgctt  ggggaggga  gtgatggga  9840
gggcctggg  gcccccgag  cccccaggg  cctgcccac  ctgcacctt  gcccccaaa  9900
cggcctccc  gctctctgt  gtgggctgc  gtgtctttg  attcctcgt  gggctgttg  9960
tcgtccagc  ctccggaaa  tactttgtc  ccatgttcg  tgactactc  gccaccctg  10020
cactcactc  catcgtcat  cttgagaac  tcgctgtgg  ctggattta  ggaaccaag  10080
agtaagagg  acatggggg  aaggtggga  gggaggagg  gtctgtcct  tcatgactc  10140
ctggagagg  agatcatag  gtcacaatg  cagagctga  agtgccctt  cggatcatt  10200
agggaaact  aggtgtagt  caaggacat  gctgcctaa  gccacttgt  cagggagaa  10260
cagagccag  ctgaggact  ggtgtcctg  gtgcaggtc  tggcatcat  cttaaatta  10320
cacagcacc  ttcctgggt  ccaactctt  agaactctg  taagttttt  tgaagggct  10380
agtgggtct  caagaggcc  ttgccctcc  agaacgtgt  gacttcagc  gcctggttc  10440
caattgtaa  ggcctagat  ggggtatga  atgaggtat  attttggcc  caagtttgg  10500
gttgtgcag  gtaagagga  tcagctcta  gaaaggatt  ggtctcaca  cctaggcct  10560
gggcagttg  acacttact  taaactctt  gcctcatcc  tcatgttag  gcaaatacg  10620
gttcccagg  gttctagaa  taggtctct  tgactcact  agcatcgac  atgaccaca  10680
tgtccttgt  cttggcaag  cccacctcc  ctaacccac  tggtctgac  ctccctgat  10740
cctggacct  gtttggcag  ggggctctt  cacaggggc  gtctgcttc  taggagagc  10800
caggagggg  cagggagtg  ggggaagga  actcctctg  ttccacctg  tgtgggcca  10860
ggctgtaag  cactgccac  aaggactct  gctgatttt  gtgtcctgg  ctccttcgg  10920
agtctggtg  tgtccctgt  tgttacttt  aatgcataa  ataaaatgt  tagggttat  10980
taagaaact  attatattg  aaaatagca  aatatcatt  aaaatttgt  atatagtaa  11040
gtatgagca  tttattttt  atgcattgt  acaagatct  gctatagat  taataacag  11100
ggtaacttt  aagtagtga  gaaaatcag  gatgactca  tattttcaa  aactgggat  11160
taatatgaa  atatctgta  tctattggt  acagtcaca  gtattgtta  tactactgt  11220
tttgcttgc  ttcataata  aatagaaag  aatgcaaga  tttagttag  ggttattga  11280
gtaaagatg  ttcttttgt  tgccattca  gcacaagcc  gcctgcctt  cagaattct  11340
ctcacccct  ggtgagaaa  ccctgagtc  gggcagctc  ctacctttg  actctagag  11400
agtgcactt  tactgcttt  ccagcaggg  gagccttca  ccaggccag  gtgaaaggg  11460
taggcccct  cctgaacac  caagctgtc  atacataaa  cagacgtgc  cctgcccag  11520
gtgtgtctg  tgggcccta  catatctct  gatggggta  gatgtgacg  aatcagaag  11580
ggttagagg  ggacagtag  gccttccca  aggccagcc  gaccacaca  aatgagcac  11640
gaatgtgaa  aatagaaga  cccaggagg  agggactgg  aaacgaaga  tttctggag  11700
agatggtga  gggggaaga  ggaggtgtg  ctgagggat  ccaactgct  gaccctctg  11760
tatgcctgg  aggttcatg  aggagctga  ggagatgct  ggcttccgc  cctaccgct  11820
ctatttcta  atgtggaag  tcgtgtctc  actatgcat  gctgtgctc  ccacagcca  11880
catcatcca  ctgggggtc  cgcccccgg  ctacagcgc  tggatcaag  aggaggtga  11940
gggtggggc  ccaaacccc  gggacattt  catcttctc  ggccttgaa  gcaaccact  12000
atagggata  acctttcta  ggcagctgc  atgtgccag  ccttgccag  tgcctcaca  12060
ctaaaccgc  atcttacaa  aagccaaag  cagaggtgg  atcatccct  tagcacaaa  12120
ggggacacc  aggctcaga  agattaatg  acttatcca  tctttctaa  ccatattct  12180
tctccatgc  tgtggagtg  aattagtcc  ttttatagt  ggagaaacc  ccctagacc  12240
tttcaccaa  gtgaccagg  aaaccccca  ccttggctg  gcctggcca  gatggtggg  12300
ggggagagg  gtggaaggc  atgggtgag  gcaggagag  agtcttgga  ggcctgggc  12360
gggagggct  tcacagtgc  ggcagcagc  cttaaggca  cccacccgc  ggctgccga  12420
cgctacctg  atttcccca  ctgggccat  gcactcctg  tcaccctca  cgtcgtggc  12480
acgctgccc  tccctgtgg  gttcgtcct  cggcacttc  acctgctct  tgatggctc  12540
aacaccctc  ccgtgtcct  caagaaggg  cgcatgatg  aggacatct  caacctgga  12600
gagaacgat  agacccgct  catcctcag  aaggtgccc  gtgaggcac  ttcccccat  12660
cccactcac  gttcctatc  ggggcccgg  agcacatca  ccctggaga  cagcggtaa  12720
cccaatgga  gctatggga  cggctacct  ctggccagc  cccctgagt  ggagctgtg  12780
ccactgccc  agccctgcc  gcctctccc  ccacgctca  cctgcccac  tgtccaggc  12840
tggcctctt  cttgaggtg  ccaccaggc  caggccagg  cctttgccc  agaagagag  12900
gtctgccct  cctcactcc  ctcttcagt  ccagtagac  ctgctccct  gccctgagc  12960
ggaggctgg  agcagctct  tttcctaat  caggacccc  ctcatctag  cctccaaga  13020
cctccgcca  attgtagcc  tgtaattgg  acaacccat  aggcctgct  cccagtcca  13080
gggagattc  aagtggcca  tgcaggagt  actcacctc  ctctctccc  gtaacttgc  13140
acctgcagt  cttagggct  tggggtcag  tggtggtgg  gagaggcct  ggggctggg  13200
aaggagagt  gactttggc  cactctgcc  tgagaacag  acaccatcc  gcccagccc  13260
gacggggtt  ctcctggtc  aagaggcta  ctgctccaa  gcggagggt  ggagcaggt  13320
tgccagggc  cagggctca  acttgggag  gcctaggca  aagccccaa  ttctgtttt  13380
tgaggtatg  gctgccctt  gcttcagca  gagccttgg  agcagaagg  gaggaacct  13440
ctctgccct  gtccctggg  ggaatcttc  catgtcctt  gccctgcct  gggtgtgtg  13500
tgtgtgctc  tgcatcttg  ctgggagtg  agtgaccgg  accagaacc  tccccacct  13560
aattagggc  tagccatct  cctgtcccc  gcacccctc  ccagcccac  gtggtggcc  13620
ctgcctctt  cctggagag  gaaggacag  gcacggaga  gtttccaga  cacaaattg  13680
tggttccta  cacaaatta  atggtttgg  gcacaatgg  gaagcacac  cccctccct  13740
ctcacctgg  gtccaatgt  ctgtctagt  gcagctttt  ccctggaac  ggggtccct  13800
gagttcaca  gcttatccc  aggaagcct  actcctggg  aaagacaga  aatttcact  13860
cccctttga  ccaccactc  ctctcctta  tacacaagc  cagccgccc  gtgtgcaca  13920
catgtgcag  caccttgga  acctttccc  agccttcct  gcccacagt  gccagtgcc  13980
taggcagtg  tgtggacag  agaggctgc  aaaggcaag  gctggtctt  aggatggag  14040
ccagcctgt  cagaaggct  cagctgaca  cagcgaccc  acctgccat  accttcagg  14100
cctcctctg  aagagaacc  attctcaga  tgcagccag  gaggaacct  acccaagag  14160
aaatgtctg  agagagatg  atggatgga  ggatagatg  atggatggg  tggggagtg  14220
gggtggatg  atggataga  ggatggatg  atggatgga  gggttgggg  gtgggggtg  14280
atggataga  ggatggatg  atggacgga  ggggtgggg  aaggaagga  aggagggag  14340
aaggaggga  tactggctc  atctttgag  gctctggtg  gcagggcag  aacaggcca  14400
agtgctcaa  ccggacacc  tcacgaagg  tcgcaagtc  ctcttgtgg  tcagattgc  14460
cttaggacc  ggagggaca  accagaatc  gggtcccct  ctttacccc  gagttcctt  14520
ctgttcccc  aagcctggg  gcagtctat  ccccaaccc  gccatctcc  ttactcatc  14580
ctcttccac  gcttcccct  tctagcccc  tctgcccta  ctgtctttc  tgagtgttt  14640
aggggagag  gagacccac  tctccccaa  gagatgagc  tttggggca  aacatccca  14700
cgcagtccc  ctcacccga  aacacctcc  acctggccc  ttgccaaat  ccaagcaga  14760
ttagcaaca  gaaaagcag  gccccagga  agacactct  ctatatata  tcttctata  14820
attctgttt  tattgtata  tcactctgt  catgtgggt  taaatgctg  taaatgaca  14880
acccaatat  atactgtgg  tggtggact  ttttcatcc  cagtgctgt  cagatctat  14940
ttcattgta  atttgatat  tttttaatt  tgtagcgtg  ggctgggcc  ggccccagc  15000
ggaggggct  agctggggc  gtgtgcttg  taggtgtgg  cgcgctagt  ctcgttgta  15060
ccttttgct  tgtcttcgc  gtgtgttag  cgtagggcc  agagctcgg  gtgtgtgtg  15120
gcgtgctgt  tgtatggtg  gcacatacg  gagtgtggg  gtgtgtagc  tgctgatct  15180
tgactccca  tgttcacca  cttcctgaa  accacgctc  ctccccctg  ctcctcctc  15240
tcctcttgg  tctattggg  gcctcaggg  cggcagggt  cttcgggag  cccctgcta  15300
ggggaaagg  atgtgtttc  tgctggtga  tcattgcct  cacaccact  ggtttgcca  15360
aaacaggga  ggagggcgt  aagggaaaa  aaaaatcct  aaatttatt  accagtcag  15420
ttcttgctg  tcccagtag  atcgctagc  cttctccag  ggaaaagta  taggattct  15480
aagatggcg  gaccccaag  gggatctca  agcactgct  catttgccg  tgacgcagt  15540
ctgacagtg  ttgaaaagg  ccgcctgcc  cctccccac  gtgcttttg  tgcctttgg  15600
gtcaaaggc  ggtggggtc  cctgatgag  taagatcca  ccccagaat  ctggaggag  15660
aggaggtag  aggagagga  caggtcccc  agtcccttc  cagggtccc  acccccact  15720
gctttggtg  tgtccacac  gtgcccacc  gaaggcaga  ggaactcca  ggcagggat  15780
tgcctgaaa  agtcaacag  cccctgatc  cctacctct  cctgccctc  agccccatc  15840
ccagcttct  gctcaggga  acttccgcc  tcctcactg  ggcaacatg  agcccgagg  15900
ccagatggg  gctgaacag  tagggcaca  cagttaatg  cagtgaggt  agcttctgc  15960
ctccagcaa  acatgtgca  gggttgctg  tttcccagt  ccaggagaa  ccccgctcc  16020
agtcagcct  tgtgggtca  gaggctggg  cccaggaga  acggtccca  gcactgcac  16080
ggcctgcag  attaccagg  ggaggggct  cttttctgc  cttcctcac  cccacgccc  16140
accccactc  cccagagta  tccccactg  gaaaagagc  ggaaactaa  ctggttaga  16200
tgaacctgg  tccctgagc  tccctggat  cttcaaata  gccctgaga  gtgaggtct  16260
ctgcttcac  ggggcccga  gactttggc  gggggaggg  gcctagggc  tcttctcat  16320
gaaagctct  ctttataca  acccaagca  acacaccag  ccgtcactt  gggttctgg  16380
ataagttca  aacaattca  gtccatgtg  cccatggct  gtcagagcc  tgggtcaaa  16440
ccactcagc  caggggagg  gatgaggca  tgtcaccct  gacccctct  cctctctcc  16500
ccaccatag  gtgcaataa  gtgtctgtt  ttaccaaac  cttcttgcc  ttctcacct  16560
ctcttgcaa  gagggagag  gaagggtgg  caaggatcc  gcgggaagc  ttggggtga  16620
aagcttgga  tgggatggg  ggacaggac  gctgagggg  gttgtgggt  ctggctggc  16680
gaggagcag  gcggggagt  tgcacaggt  catatctgt  ttttcctat  aattgtcct  16740
ggtattaac  atgcacaca  ttgtagagg  ccctattgg  gtccagcga  tccacatgt  16800
taatttcct  tcatctttg  aaccgtttc  taagggaga  cctttgctg  ctacatttt  16860
ccaggtgaa  ctgcatctg  aattaggat  gtatttggt  gtctcttac  ggaccctgt  16920
ggggaaact  ctgtcccac  tgactacca  gaaaagcta  acttgtcag  ctggcaagg  16980
tggggtgtg  ggaggccca  ctcagggaa  gacaggggt  ggaaggtgc  agtgttgag  17040
ggtctgaca  caaggacca  gactctctt  ggtgctggg  tgggggggg  gtgggctcc  17100
ctggaacag  catattcta  agttctgcc  ctctcttca  gatagctat  cctcttgca  17160
acttcagta  aaggtaaag  cgaactagg  gatctgaca  cacctctgt  ctaacattc  17220
agccccaag  attcattta  taaacaccc  ctgaatact  agcactgtg  agaacggac  17280
gtgctggtg  ctgggaagc  cttcttcct  cctcaccct  taggagcac  gacattgaa  17340
gaaacaaga  gtctggctc  tggaggagg  ctcaccccc  ccccaccca  ctccaggct  17400
gaatgatgc  gcttgcact  agacgcaca  agccaagga  cctgaagga  cctgccatt  17460
tcttctctt  ccatagaaa  tgttgttcc  ggaatagcc  ccagatggc  ggaaaacct  17520
tctcgccag  tcatagtct  cttgccttc  tctctgtca  ttattcctt  gtgggttag  17580
ttatttgtt  aacaaacat  tattacgta  ccaccctgg  caggctcca  gccagctat  17640
gatgaataa  gataaaatc  gcccctgct  tcctgagtt  ggcagaggg  ggggaccgg  17700
cctataact  cacatctcc  catgtatct  tcaaaccag  aaatggcct  gtgctgaaa  17760
tcactcctt  tcaagtatt  agtcttttg  ttgaaggta  tgtttttgg  tgagatgca  17820
gccctcttg  caggagggg  acacagatc  accaagatg  agcataaca  gggctttgg  17880
tccaaggag  tctagagtc  tacttctca  gttcaagtt  aaatgccac  cagcttcct  17940
cttcctggg  ggccttgag  gagtcattt  atcgctctg  gcttaaatg  cctagtctg  18000
aaaacagac  taataaata  attcaatga  ataacacat  ttggtccag  tatctattg  18060
tgtgttcca  gttactcca  gtctgagcg  cttaaaaca  ccattctat  tcgcagttt  18120
ctgagtaag  aattcaggc  ggactcgtc  gagcaactc  tctggtggc  accaaggtc  18180
ctcagtgat  ttcaactag  agcgaacta  tctggaggg  ccaaggcag  tgccctcac  18240
ttcactcaa  tgccgggca  tccagtgag  atggctgga  gactgagtt  agctgggcc  18300
gccggccag  gtgagcacc  acaactgcc  ctccagcat  gctacttgg  cagacttct  18360
actgaaggg  ttagggtcc  cagagagac  atttcaaga  acaggaggt  gaagctgcc  18420
ggtttttaa  gcctggggc  ggaaaatgg  acagtacct  taccatctt  tgtgggtca  18480
agcatctgc  caaataaag  ggagggcac  cagaagccc  ccttgttga  ggggagtgg  18540
gagagtctg  ctgcccatg  aatgggctg  ttctagagt  ttagggatc  ttgtcatca  18600
tcacctgca  atgcatgga  gccttctcc  gaggggatg  cagcttaga  acacagaac  18660
gggacacac  gcaggtcat  tctggtggg  aggtgagtg  ttaagtttg  gccctgggt  18720
gagggagca  tcagaggag  atgagaagg  catgcagga  gacaggtga  gccactgct  18780
ctgcctcag  tttgcccca  ggcaggtgg  atgagtggt  tgaatcatg  gtctgtcgc  18840
aaccatacc  ccttgggga  gccacttta  ccctggaat  tccattttc  gatctgtaa  18900
aggaggacg  caataaaat  tcttcctta  agatggtat  agggaaaaa  gaacttcat  18960
agtaacatc  actggaata  agtatcgac  tctttccat  tggggatac  ataggtgct  19020
attaaatat  tccttcctt  cttcttgcg  tcctgggca  ggccatggg  cctacttca  19080
tctgggggc  ccatcaccc  tgcaatgag  catctccta  agctattca  aaaggacag  19140
ttcagccta  aatccagag  agccaagga  ggaaggcag  aaaggaact  tctccagga  19200
agggagtac  agagtgtgg  ggtctcact  atcctgtac  ttatcatgt  caccccagc  19260
gtcaccacc  gacagctcc  gtcataggg  cttgggcca  ggctaaagt  ttccacaga  19320
cacaaggct  ttgtggggt  ttgtttttg  tttctttgt  gttggttgg  cccaaattc  19380
ttttaatac  tctcccatc  aaagtggag  ctatgctcc  cctcttgaa  ctgggtgag  19440
aaatgcttc  tgtgaccaa  agggtatag  agaagtgat  ctatgtgac  tccaaggct  19500
gattaggaa  ggccgtgcc  cttccacct  gtgttctag  gatactcat  ctagaggca  19560
ccagctgcc  tgtaagaca  ccaaccacc  tgagactgc  atgctaggg  ggcgatatg  19620
ttgcagatg  ttaggttga  agcttcagc  gagcttcca  ccaacagcc  gtgtcaact  19680
ccagccaca  gaacacagc  tactgaacg  ttagcccag  tgagcttca  atgtttgca  19740
cccgctgac  tctgattgt  gctgcataa  agaccctaa  caagaactg  tcaactgag  19800
ccttcctta  ttcctgacc  ataaaataa  aaacaaaat  aaatggctg  tgggtttat  19860
tcactacat  ctaggggta  tttgtttca  aacaatagt  accagaata  gaaccttag  19920
gattatctg  tcaaacctc  ttgtacaac  atgggggaa  cggaggccc  aagaggaaa  19980
gaccagact  cccacaacc  agcaagggg  agatcgggg  caatgcctg  gtttcttga  20040
tcccaatct  gtgcactct  tgccacaca  caagaaact  acagggagg  ctcctcccc  20100
gccaccccc  gcctcatta  ttccatgca  caagcaagc  tgaatcagg  attttgagt  20160
cctgggatt  tgctgagca  tgggaatat  caaaggacc  ggcaagagt  cctggctcg  20220
agaggcagt  acaatctga  ttgggcatc  cccttcctg  cacactcac  ggtgccagg  20280
acgctgctg  attctttaa  tacatcatc  taggtggga  gaaaccttg  gatgggaga  20340
gactatgcc  gtcattcaa  cacaaaccc  tacaaagat  gatccatgc  aggcacagt  20400
ctggctgca  agcataaag  ctcagtggg  atctgctct  tgtccctgg  tctgagctg  20460
ctgggttct  ggtccctcc  ttctgccca  ggctgaccc  agcagggaa  aatccctgg  20520
cttcaggag  acccaagag  aacctgagt  tggcctgtc  ctccagaca  ctgcttccc  20580
tttccccag  atattgctg  aggggactg  gcccatcag  actaattaa  tcctctaat  20640
gaatgaacc  gtttttcct  gaacttagc  caggtggga  caatctcta  ttttctaga  20700
ggagaaatg  taagtgtca  gaggtcttg  cagccggac  ctgggctag  gtgcatgtg  20760
caggcgcgg  ggcgggagt  tgctgtctg  atgcaggct  agttcccag  ccaggagcc  20820
taaacaagg  ggcctctag  gtccactca  ctggtggcc  ccgtatcgt  ctctgtcct  20880
ggcccaaca  cagccctag  tccgtctct  agagttcgc  gctgctgct  aggcctgac  20940
tccctaagc  gggggaagg  gtccatgag  taacactca  gtcccctcc  accctatga  21000
tccaggtcc  tagtgtatg  ggccctgag  cctgcccag  cccgagctt  tgatctctt  21060
tctttaaga  ctgggcctt  aaaggccac  tttgagccc  agatacaac  tcactggga  21120
taccacagc  acccaaccc  gctttcagt  ctgaggcag  gccattcta  tgatcttca  21180
aagacctga  ttactaggg  taggttctc  ccagagccc  tcccccacc  acccccctc  21240
ccccaaaga  ggctctcac  tttgatttg  agcctgcaa  tctctgcag  ctgcttggg  21300
ttgggggag  caggatgaa  tgagctgag  cgcagacag  aggctgcca  cctgctctt  21360
ccttccctt  tcttgttcc  ccatgagcg  ggaggccct  tcaccctct  atgagtctg  21420
taaagcaat  caattttcc  ggctgggag  gagtgaggc  tgctgggaa  ggatgctgg  21480
tccttggcc  ggacctgaa  gagggtcag  ccctggcag  agctagaat  ccaaaaagg  21540
aaagtgtga  caccaatgg  tagaacctt  ccttggcct  gagcccctc  ccacaaaca  21600
gtttcaaag  aggaagatg  agaggagat  ggatggctc  agtcatcct  aagaggctg  21660
gcccataca  agctcccag  ggggaaagg  gaagggtaa  cggctttga  ttcaggctt  21720
cagcttcct  cggacaggg  cagcgtcgg  actcagagg  tgaggacct  attatgcgg  21780
tggaggggg  gcctggaaa  ggtgcaggt  cttgacagc  tccatcggt  cccctttag  21840
atctcccat  gccctctct  cctattctt  caccacacc  tcacccctg  tgagggaaa  21900
ccgctgtgg  tgacacctt  tgtgaactg  ctttcagac  ggtgctctt  cctgacagc  21960
tgaagaagc  agggcacta  ggagaggac  aaagagaaa  ggtgaaaat  agggaaaga  22020
gcttgggga  ctaggaatt  ccaatagtg  ctgctttgt  gtcttgctt  agcctgtca  22080
gtatcaagg  cttggagga  tgaagaagg  agggagtag  cagagtccc  atggcagag  22140
taggctaga  gatgtacct  aggtcctgg  atcaacagg  agcccagaa  cagctgcca  22200
cccatctgc  cacatcaca  cccccagag  tcagggcga  gtctggagc  aggatgttc  22260
agcaccacc  gagggcagc  ccctcacat  catggtagg  tgtgtcaca  tagcctggg  22320
agggggctc  cctatcctt  cccggctct  tgttttgag  gaacaccaa  acctcacac  22380
aagaaatga  ggggacaag  cccatagtg  taactgcag  atatcgact  cctcagaga  22440
gtacacgta  caggtgagc  cagagttct  gaataaacc  tcagcaagg  tgaggcatt  22500
tctggaggc  tcaggactg  ggctgagct  ccctctccc  agctggtca  tgcacagag  22560
tgggagtcc  ggccccatg  acctttacc  agctgcctc  ctcaggctg  gccctctgt  22620
tttgtcagc  cttcctagg  tcctatgcc  gtgtcccaa  tttctgatc  tcctccctt  22680
cctcttggc  tcctttttc  ctggcagct  tctcccttt  cccatctcc  caggtgctc  22740
tcactatcc  caagcaccg  agagtggaa  caccagttg  gcagattta  taggatgag  22800
ggctgtttt  ttcactgat  tatttccag  acccggaac  gcttctggc  tatcgtagg  22860
attcaataa  tgttcattg  gttaataag  caatcaggg  tgggatact  tgggttttg  22920
ccccttgcc  actacactc  ctttgttac  attactgag  tcagtcatc  tgatgaacg  22980
aaagcaggg  agagacccc  agggacttt  ccaggacac  gaccagata  gacttgaaa  23040
ttattcatt  cattaatat  ctgtggttc  ttcttcctc  ctccagttt  tggcctgtc  23100
cgggtcttc  cttcccagt  acacttggg  tatttcttt  cactgcagc  aactcaaag  23160
cagctaaac  ctgaaatac  aacatcagt  tcgaggagc  gggactggg  acaaagggg  23220
tgccagtaa  tgtgtgttt  tgattaact  acctcccct  cgtgtcagt  cagatcatc  23280
aagatcatt  tcattttgg  tttctggcc  cattaataa  gagactttt  cttgtaaaa  23340
tcccttgca  tggcactga  cttttaacc  ttcctgaga  acacatagg  ccttgtctt  23400
tttttctca  ttgagctag  tactgcctg  tctggaact  ggaaggtgc  caggtgtcc  23460
gggcaggtg  gtcattcac  tttcatttc  gcctcaaga  ctctttaca  catccagac  23520
ggcatggag  ctgcctgaa  ctgtaaaaa  gaaaaaaaa  cccaatggg  attaatatg  23580
agatgtaaa  taggttctg  acttaacaa  aacaaatga  tctggaaat  gctcttggg  23640
tagggccag  aaagtcctg  tggtgccta  gttttgggt  tggcagctt  tcaatcact  23700
agcaaacag  ttctcagag  caggcactg  gggagctat  aagatgaaa  agcacaatg  23760
cgcctgcag  agctcaggg  tagggaggg  agaggagac  tatacacag  caaagtcaa  23820
ttgtaatgg  tagaataag  gtagaaaca  gaaggggtc  tgaggcagg  cacgggcat  23880
tcctatgtg  accccagag  aatgacgag  aaaggcttt  actaatgac  tttcagggc  23940
acccaccca  tccacatcc  taaaacatt  cgcgatgaa  acagccaga  ctacggttt  24000
cttccatcc  gcacaagaa  cgcttctct  cccaaggcc  ccccgtcct  cattccatc  24060
cggggactt  ggtggctgg  acagaggcg  agagcatca  gaccatggg  gtcttgggc  24120
acgttgggc  tccgaggcg  aggatgcgg  gcggggtgg  cagaaggcc  caacacggt  24180
cctgggaaa  gagagggca  cctgatcct  gcgacagcg  ctctaccct  tttcttcct  24240
ggccttccg  cagccgcag  gaaacggca  cagtgcgac  agcttggcg  ggagggggc  24300
agggacgaa  caagaagag  cgggcggag  ttagaggtc  ggggtcgag  gcgcttcgg  24360
gtcagcggg  tgcggtggg  ggagctgcg  gcccggggg  ggcgcggag  agggctgag  24420
ggggcggga  gggttgccg  cggaagcgc  caggggcgg  gcgctgggc  gggcactgg  24480
ggcgaggag  tgacgcgct  ggttggggc  cggctccgg  gaggaagac  gcgctcggt  24540
gccagggcc  gcagtgagt  ggatcggcc  cgcgctgcg  cgcgccccg  ccaccccgc  24600
ccgcgaagg  cgcgtctgg  cgaggcggg  ccccggagg  aaaggcgcc  ctggggcgt  24660
gcggccgct  ccagcgccg  agggagacc  tgagcccct  gggccccag  ccaccggcg  24720
cgaggcgcc  cctccccta  gccacctcg  gcccgcccc  tgccgcgcg  gagccaagg  24780
cggcgcccc  cccggagat  ggcagacgc  tagatggcg  ggctcccag  gccgccaga  24840
cgcaggaac  aggcgccgg  gcgttgcgc  gaggctccc  ctccgcgcg  cccgggaag  24900
ctgcaggtg  ccttggccg  tcggccgcc  cccccggta  accttcgcc  gtgcccaga  24960
cccggctcc  cagagcggc  ccgcccccc  ggctcggcg  cgcgcagga  gccccgtct  25020
aggcacccc  gccccagcg  ggcccccgc  gcgctgcgc  cggtccggc  cagctccca  25080
ccgcggacg  aggacccga  gctcgctcc  gcgggcgcg  ttgttttcc  gctgccgcc  25140
cgccctgcg  agcccccgc  cgcccggcc  ccgctctct  ctctgcccc  cctgccttc  25200
tcgcccggc  ctggattta  gaatggggg  aagaggcca  atgccgccg  cgccgcctc  25260
tgttgaccg  aagcagccc  ggcccacgg  gctccggct  ccgtgagag  gtcggcctg  25320
ccccggcag  cgctcggag  acttgttgc  gctgcgctg  cgccgctgc  gggaagccg  25380
ctattccgg  gcttggtgc  gtcttggag  cggagggtg  cccgtgtga  cgcgagcgc  25440
ccggacctt  gcggtgcgc  tggactgtg  gcttcctcg  ctttggtcg  ggtgaaggc  25500
ggggcgtgt  cccggccca  agcgtttgt  tgtcccgtc  tagcggggg  ccgcgtgtg  25560
gcttgcttc  acttccccg  gtcctccct  tctgcgcct  cctctctcc  gagcttcct  25620
ccctaaccc  aaccacctg  gtaccggag  aatccaact  ctcccgctc  gcgtcctag  25680
gggataggc  ggggcaagc  caagccgca  agggggccg  caccgcctc  tgcctcctc  25740
tcgtctcct  cccctcccc  gtctgacgc  gcctcctcg  gaagggtgt  tggagggca  25800
cggccgccc  aagccggag  cccgcagcg  ttcttatga  cagctcggt  tgtgtctcc  25860
cctaccgcg  gcgcaagtc  gggaacaag  ctccgtcca  aacatgtct  aaggaggag  25920
tggccaagg  cgaggcgtc  gagaagatc  tcatcaacg  gggcggcac  cgacatgag  25980
cctaccgca  caccctgcg  accctaccg  gaacccgcc  cgcctggct  gccgacccc  26040
acggcgggg  ccggcccga  accgatggc  gcggtgtgg  tagcagcgg  agcagcggc  26100
gcgggggct  cgagttctt  ttcgacagg  acccgggcg  cttcgccta  gtgctcaac  26160
actaccgca  cggcaagct  cactgcccc  cggacgtgt  cgggccgct  ttcgaagag  26220
agctcacct  ctggggcat  gacgagacc  acgtggaac  ctgctgctg  atgacctac  26280
ggcagcacc  cgacgccga  gaggcgctc  acatcttcg  gagcccgga  ggaggcggc  26340
gcggcgcgg  gcccagcga  gaggccggc  acgatgagc  ggagctggc  ctgcagcga  26400
tgggccccc  cgagggagg  gcgggccat  gcgccgggt  tgggggctg  cgcggctgg  26460
agccccgca  gtgggcgct  ttcgaggat  cctactcct  ccgggccgc  agggtgagt  26520
gcaggagcc  gtgtctccc  atcttgggt  tgcaagggg  ccgtggtgg  tggtgggta  26580
gggccggga  gagcaggga  cgagcctga  ttaccttac  accgcagat  gttcccgcc  26640
tcctctcaa  ccccctccg  ggctcgcag  ggaattaca  actcccacc  tctcccctg  26700
acgctccat  aggagattg  acacacttg  cttactact  ggacccagt  ccagctgcc  26760
gctttgccg  atcccctcc  gtgagtggg  tgcccagct  agctcctcc  cccccttct  26820
tggtctgca  aggctgccc  atcttcagc  gccctccac  ccacacagg  ctacggtcc  26880
ggaagagct  gaatttggt  ttctgatgg  ggcaggcag  gttgagagg  aggaaacta  26940
ggtgggttt  gttagatgc  tccatgccg  gccacctca  ttacatcct  ccagcagct  27000
agtgtgctc  caactatgc  cttcagaga  gaggatata  gcttcagca  cttaagctc  27060
gaagaggca  agctgagac  acaatccgg  ctcctttcc  ggtttaaga  aggcattct  27120
tctgccagg  aggatacca  gcccctgag  cttcctgca  acctgggat  tcctggcct  27180
agctggggt  agaggagaa  taaacacga  gggcctagc  ttctaggct  tgcaggctc  27240
cacggccag  ggccagcca  aggcttcct  gtgatgata  cagattttt  ttgccgctt  27300
ttttctttc  gctgcagca  aaactgtct  tccagaaag  cctggttca  gttactgct  27360
gaaatgggt  tatgaggga  gggggaagc  caggttgat  taggcaaga  ctaccgcct  27420
ctccccaag  aaatccagt  tccctaact  ctttaggtg  aaggggaga  cgggggagg  27480
gcttccccc  ttatgcttc  acagctaaa  aaaaaaaaa  aaaaaaaaa  aaatccctg  27540
aggatggct  tagattctt  aaagaaaga  aactctggg  gctggtgtc  gatctcatg  27600
tcagcagcc  aaagcctgg  tggagtctg  ctgggagac  ggaaagagc  atgtaactt  27660
ttgggtctg  ggactgctg  ttgctgtgg  acctggttg  ttcctccag  atcccaaat  27720
gtcatgtta  tgagtctca  agcaccctc  ctttcccag  acccctgtg  tggactcct  27780
cctagtcat  gaagaaggc  gggtaggga  ttggggaac  ggcctgcag  gaaaagcca  27840
gctggcata  atgccaggc  agggcagat  catcttctg  ctggaagag  agggaggag  27900
agaggtctc  ggggccatg  cataccggg  tggggctgc  ggcagccac  agaaggcag  27960
gatctttct  aggactgac  acaaagcta  aggcaactg  ctgggtttc  ttccttgca  28020
ccctgagac  ggctaagaa  gtgagggca  agtgatgcc  ctggcctgg  tctgctgtg  28080
gttctacag  cttctcatg  aggtcacta  ccttgctag  gttagcact  ggctgtctg  28140
attagggga  agagggcag  cacacatca  tcagactct  tcaaagttg  gggtcgggg  28200
ggagagata  agatagaga  ggggaaagg  gacaaacca  ggaagcagg  atgagatga  28260
gtggttagg  gagctaggc  ctatttctg  gcattctgg  acttctagg  gcttttcac  28320
tgctcttct  cccctctgg  attccaggt  gcaccccac  tatcattga  tttattttc  28380
tcctaactc  ctgctgaat  gccaagcca  ggggcctct  tgagtaagc  cagagcctg  28440
cctgcccct  gaagtcttc  caggaaccc  gggtgcttt  cccctttga  atggaatca  28500
atcagccca  gcattccag  tgaggtctt  aagtttatg  tggagcaag  ttaattctt  28560
catttaaac  ttgagaaaa  caggattca  agacattaa  tttcttgcc  aagacattt  28620
actaatagc  gaggcagga  accacccct  gtttccagc  ttctggttg  tcatcctga  28680
gtgaatatc  ggatggagc  ctggccaac  catgcacta  aagaggact  gcctcctgc  28740
caggagccc  ggcaaaggc  accctcacc  gctcccggg  cacacaagt  ggaatacat  28800
atttttaca  attaatgaa  aactgctca  tattgagca  cccagacag  tacattgct  28860
tatatactt  acattaatc  ctaatcctc  caataaact  aaaacccgg  gattatccc  28920
gtttaatag  ttgaggctg  gagaaggta  acaacttgc  tgagatcac  cagccagat  28980
gtggccagg  tttgaatca  agccagagt  cctgactcc  aagcccttg  tcttgtgat  29040
acaacacct  ctttccact  aactaggct  tttttgagg  agagagctt  tttcttact  29100
tagcctgag  aatgtcctt  tgaggttct  tacctcctg  ggatgacat  agaaaaccc  29160
ggggcagat  gagacgtca  aaggaagac  tactgtatt  cccctccag  cctgagggt  29220
ctatgccat  cggggagtt  tggggctgc  ctttccccc  tccatttgc  cctggcttg  29280
cacactgtc  catccttcc  agccctgtt  cccccggta  atgtgctac  ttccctcgc  29340
cacagctac  tcctccctg  aagggcccg  agcactgtg  ggtggtggg  gaagaggga  29400
agaggagca  tgctctgcc  tgaggcgtc  tttcgcaca  agcaacctg  tcatttgag  29460
agtgcgtta  gacaggagc  aaacgatac  aatggaaag  gaactgagc  gattatgag  29520
gcctgttgc  tagctacag  cctggccca  ggagctgtt  cgctcaggc  ggctcctgg  29580
ctgggatgc  cacccctgc  ccactgtgc  gggcccatg  gcagctgct  ctgtggttc  29640
gtttctgtg  cctgagctg  gaacaggta  gaggggcag  gcagagtga  ggctcaccg  29700
ggagacttc  cagcctcag  gggcccagt  gaggtttgg  agcatccga  actttagaa  29760
cctgcacct  cttttctga  agcagacaa  aggcctgga  aatggggcc  ggatgccct  29820
cccctaccc  agtctccaa  gtctccagg  cagggctgg  tttagctca  ctatcagcc  29880
tattaagga  tacagttcc  ctcctttgg  taaatcagc  catttttcc  gtgatgttt  29940
ccttttgag  agaggaggg  acccacagg  actccctgc  ccaggaagg  agctccagc  30000
gggtcttcc  ctttgttaa  tgtcagtta  tatgtggga  gcttggcct  tgctttctg  30060
tactactca  ctggcctag  tgaggcaga  attgttaac  tctgtgtat  agtatacag  30120
taaggaaac  ggcctggtg  ggctttctc  aggtcgcac  acttgtggt  gaactagga  30180
ccaaaccta  gtctcatca  tctaagtct  tgctcctcc  atggcctct  gctcctgcc  30240
agagaggat  tctggtttc  agagggtgg  ccctcactg  agagcttct  cctccactc  30300
gctcttatc  gttccttta  ttctcactc  ccagaattg  tcaaggata  cctctcttc  30360
cactgtggg  tttccatag  aaaaatgaa  ggaggcgtg  ctgggagaa  agactaagg  30420
aagctccct  gcccaggca  agcatgaaa  caaggcctt  taggaaagg  gcagagctg  30480
attcctgcc  gcccgcttc  gaagttccc  ggcttctct  gtccgggca  tgcctgggg  30540
acaggtcag  gatcacgac  ggctttaaa  tgagggcca  gactcactg  tgctgtgcc  30600
tctgagcta  ggtgaacca  gaacctgag  ccaggaggg  agtaccctg  ctttctgag  30660
tccccagga  ggcagtgcc  agcctgccc  gggcagccc  tccacctcc  tcctgagga  30720
caggcaggg  ccaggctga  ggctgcagg  ctccctgca  gccctgccc  cagggcatc  30780
tcccagttt  ctcttgggt  tgttttctt  tcttgttct  aacagatca  catttgtct  30840
tgaacatct  gtctctgaa  gctgaggtg  ttctggttg  cacattagg  gtggggtgt  30900
gagtaggga  ggggagaaa  taaacgagc  attttggag  ctcggggga  gagcaggca  30960
gcaggagca  agccaggca  cttggcctt  agggtagga  accctgggc  cttcacccc  31020
acccatggg  agtgtcagc  tgggatgct  ggcaccaga  ctctgtgca  ccctcattc  31080
ctgtgcgta  ctgacttgc  atgacctct  gccctgctc  ctgctggaa  tttcttcag  31140
ctaaggggt  gtcacctgg  ccctagcag  ggtccttat  tggaagtgg  cctggctcg  31200
tctggaggg  agcagaggt  ctagggccc  agcacctag  ggtattact  ggcatatac  31260
cttgtcact  tgtcccagt  agtggagct  atgacctct  cttctgaca  gctcatcag  31320
accaggaga  agagcaggg  gtcaccttg  ccccagtca  tcagaaaac  cttactgcg  31380
acttaccat  cacatgtgg  gttctagaa  tccaaagat  agtcagagg  ggccatgct  31440
ctgacaaaa  ccaagtcgg  tagagtaag  ggcagtcaa  ggaaattag  tgacaagaa  31500
tggcaacag  aatacaaga  ggatcatga  aggtgccac  ggagtcgta  gaaaataaa  31560
ttcaatagg  agtgagagg  ggaatcaat  aatcccacc  ctacgtggg  tgaggtgta  31620
gaggtgttc  gagaggctt  cacaaggaa  tagaagttg  attgggtgg  ccttgtagg  31680
tactgactt  gtgccttaa  taatttttt  aaagagtca  attataaat  catacat  31737



<210> 9813
<211> 606
<212> PRT
<213> Homo sapiens
<308> CAC19684
<400> 9813

Met Ile Ser Ser Val Cys Val Ser Ser Tyr Arg Gly Arg Lys Ser Gly 
  1               5                  10                  15
Asn Lys Pro Pro Ser Lys Thr Cys Leu Lys Glu Glu Met Ala Lys Gly 
             20                  25                  30
Glu Ala Ser Glu Lys Ile Ile Ile Asn Val Gly Gly Thr Arg His Glu 
         35                  40                  45
Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr Arg Leu Ala Trp 
     50                  55                  60
Leu Ala Asp Pro Asp Gly Gly Gly Arg Pro Glu Thr Asp Gly Gly Gly 
 65                  70                  75                  80
Val Gly Ser Ser Gly Ser Ser Gly Gly Gly Gly Cys Glu Phe Phe Phe 
                 85                  90                  95
Asp Arg His Pro Gly Val Phe Ala Tyr Val Leu Asn Tyr Tyr Arg Thr 
             100                105                110
Gly Lys Leu His Cys Pro Ala Asp Val Cys Gly Pro Leu Phe Glu Glu 
         115                120                125
Glu Leu Thr Phe Trp Gly Ile Asp Glu Thr Asp Val Glu Pro Cys Cys 
     130                135                140
Trp Met Thr Tyr Arg Gln His Arg Asp Ala Glu Glu Ala Leu Asp Ile 
 145                150                155                160
Phe Glu Ser Pro Asp Gly Gly Gly Ser Gly Ala Gly Pro Ser Asp Glu 
                 165                170                175
Ala Gly Asp Asp Glu Arg Glu Leu Ala Leu Gln Arg Leu Gly Pro His 
             180                185                190
Glu Gly Gly Ala Gly His Gly Ala Gly Ser Gly Gly Cys Arg Gly Trp 
         195                200                205
Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Ala 
     210                215                220
Ala Arg Val Val Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser Ile 
 225                230                235                240
Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile Asp Arg Asn 
                 245                250                255
Val Thr Glu Ile Leu Arg Val Gly Asn Ile Thr Ser Val His Phe Arg 
             260                265                270
Arg Glu Val Glu Thr Glu Pro Ile Leu Thr Tyr Ile Glu Gly Val Cys 
         275                280                285
Val Leu Trp Phe Thr Leu Glu Phe Leu Val Arg Ile Val Cys Cys Pro 
     290                295                300
Asp Thr Leu Asp Phe Val Lys Asn Leu Leu Asn Ile Ile Asp Phe Val 
 305                310                315                320
Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser Ser 
                 325                330                335
Lys Ala Ala Arg Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe Val 
             340                345                350
Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu Arg 
         355                360                365
Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu Leu 
     370                375                380
Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile Tyr 
 385                390                395                400
Tyr Ala Glu Arg Ile Gly Ala Arg Pro Ser Asp Pro Arg Gly Asn Asp 
                 405                410                415
His Thr Asp Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val Val 
             420                425                430
Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Lys Thr Trp Ser 
         435                440                445
Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr Ile 
     450                455                460
Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr Ser 
 465                470                475                480
Leu Ala Met Ala Lys Gln Lys Leu Pro Lys Lys Arg Lys Lys His Val 
                 485                490                495
Pro Arg Pro Ala Gln Leu Glu Ser Pro Met Tyr Cys Lys Ser Glu Glu 
             500                505                510
Thr Ser Pro Arg Asp Ser Thr Cys Ser Asp Thr Ser Pro Pro Ala Arg 
         515                520                525
Glu Glu Gly Met Ile Glu Arg Lys Arg Ala Asp Ser Lys Gln Asn Gly 
     530                535                540
Asp Ala Asn Ala Val Leu Ser Asp Glu Glu Gly Ala Gly Leu Thr Gln 
 545                550                555                560
Pro Leu Ala Ser Ser Pro Thr Pro Glu Glu Arg Arg Ala Leu Arg Arg 
                 565                570                575
Ser Thr Thr Arg Asp Arg Asn Lys Lys Ala Ala Ala Cys Phe Leu Leu 
             580                585                590
Ser Thr Gly Asp Tyr Ala Cys Ala Asp Gly Ser Val Arg Lys 
         595                600                605



<210> 9814
<211> 3146
<212> DNA
<213> Rattus norvegicus
<308> X62840
<400> 9814

ccactgcct  ctccgcagc  aggccagct  cctctcaca  taggcgcct  aaagaccct  60
aggagcccg  gcacacacc  ctggacccg  acctgactg  cagctcccc  tgagggggc  120
tggctcgtt  gttggggtg  gtggccaga  ccgcggtcc  ctgtgcccc  cgacggctg  180
ggggagggg  gaagaggcc  tgcgccccc  tccccgtcg  caactcccc  tggcggcag  240
tcccatggg  gtcgctggg  cgcgccatg  ctaaggggg  gccgcgatg  gccaagggg  300
cgagagcga  cgcatcgtg  tcaacgtgg  cggcacgcg  caccagacg  accgctcga  360
gctgcgcac  ctgcccggc  cgcggcttg  ctggctggc  gagccggac  cccacagcc  420
cttcgacta  gacccgcgc  ctgacgagt  cttcttcga  cgccacccg  gcgtcttcg  480
tcacatcct  aactattac  gcaccggca  gctacactg  ccggccgac  tgtgcgggc  540
gctctacga  gaggagctg  ccttctggg  catcgacga  acggacgtg  agccctgct  600
ctggatgac  tatcgccag  accgcgacg  tgaggaggc  ctggacagc  ttggtggcg  660
gcccttgga  aacagcgcc  acgacgcgg  cgccgacgg  cccggcgac  cgggcgacg  720
cgaggacga  ctggagatg  ccaagagat  ggcgctcag  gactcccca  atggccggc  780
tggcggctt  tggcgccgc  ggcagccac  catctgggc  ctgttcgag  acccctact  840
atcccgcta  gcgcggtac  tggcctttg  ctccctctt  ttcatcctg  tctccatca  900
aaccttctg  ctggagacc  acgagcgct  caaccccat  gtgaacaag  cagaaattg  960
gaacgttcg  aatggcaca  aagtgcggt  ctaccggga  gcggagacg  aggccttcc  1020
cacctacat  gagggtgtc  gcgtggtct  gttcacctt  gagttcctc  tgcgtgttg  1080
cttctgtcc  aacaaggtg  agttcatca  gaactccct  aatatcatt  acttcgtgg  1140
catcctccc  ttctacctg  aggtgggcc  aagtggcct  tcctccaaa  ctgccaagg  1200
cgtgctagg  ttcctgcgc  tcgtgcgct  cgtgcgcat  ctccgtatc  tcaagctga  1260
ccgccattt  gtgggcctg  gggtcctgg  ccacacgct  cgtgccagc  ccaacgagt  1320
cctgctgct  atcatcttc  tggccctgg  tgtgctcat  tttgccacc  tgatctact  1380
tgctgagag  ataggggca  agcccaatg  ccccagcgc  agcgaacac  cacacttta  1440
aaatatccc  atcggcttc  ggtgggctg  ggtcaccat  acgacactg  gctatggag  1500
catgtatcc  cagacgtgg  ctgggatgt  ggtgggagc  ctgtgcgcc  tggctggtg  1560
gctgaccat  gccatgccg  tgcccgtca  cgtgaacaa  tttgggatg  actactctt  1620
agccatggc  aagcagaaa  taccaaaga  aaaaaagaa  catattccg  ggccaccac  1680
gctgggatc  cccaattat  gtaaatctg  cgtaaactc  ccacaccac  gtactcaga  1740
tgacacatg  ccgctggcc  aggaagaaa  tttagaaat  aacagagca  attccaaac  1800
gaatgggga  gtggcgaag  ccgcgctgg  gaacgaaga  tgcccccac  tagaccagg  1860
cctcactcc  gatgagggc  tgcccttta  ccgctcggg  acccgcgag  gatacggac  1920
ctgcttcct  ttatcaacc  gggagtacg  gtgcccgcc  ggtggagga  tgagaaagg  1980
tctttgcaa  gaaagccct  tcattgcta  gtatatgcc  acagaggct  tgagagtga  2040
ttgaccagg  ggcttggcc  aggacactg  tggctatta  gcatctggg  ggacctgca  2100
cccctcctc  ccctcggac  gagtaaatt  acgccatgc  ggtttgccg  acgagtccg  2160
gtggccccg  gcattgtac  aagacggac  tagcttttt  tacggccca  ggtaactga  2220
cgtagagga  tcgcccttc  ttcttttga  tttcttttt  tttcttttt  tttttttta  2280
aagttacct  ttatttggg  agggggggt  aaggggagc  ttagcatga  ttgcatgaa  2340
ttaaacaga  aacccagct  aaccaaccc  accagcccc  gctgtgact  tatgctcac  2400
ctaaccacc  cccgagaac  agagaaaag  aagagtctc  tatttcttc  agcattctt  2460
gacacgtag  gtcggagtc  aactgtgac  ggctgcttg  tagaaccct  tacatttcc  2520
ggagtgggt  cgggggggg  gggggaggt  agggactaa  gatggggcc  ggggagtgg  2580
ttgcttttt  gtacacgag  cccagagga  aggtcccaa  aaggcagtc  gtcatcggt  2640
acattgacc  caccttcat  gctcacctc  cgctcggaa  accaagaac  atgctccga  2700
taggattgt  gaaattcac  ctgccaccc  cttccacct  cgtttggca  gcttgcgac  2760
caatggacc  ctccccaag  ccccgacag  ggctagttt  ggtcaattc  ctcatcttg  2820
tgtgtagct  cagtgtgac  aagtttcat  acaaattgt  catagttac  ccacatgga  2880
tttccaatg  cattttaaa  ccaggatgt  gagtccctc  agttcagga  caccagagg  2940
gcgcctccc  tccaccttt  ctaaggcga  aaccgacac  gtatgcaat  tagtacttc  3000
gagctcaaa  aaaaaaaaa  aaaaaaaaa  aaagaaaaa  gaaaaactg  atgcccaat  3060
ttatgcaaa  agattcgag  atgaaataa  ttttgtaac  tggaaaaaa  aaaaaaaaa  3120
aaaaaaaaa  aaaaaaaaa  aaaaaa  3146



<210> 9815
<211> 585
<212> PRT
<213> Rattus norvegicus
<308> CAA44644
<400> 9815

Met Gly Gln Gly Asp Glu Ser Glu Arg Ile Val Ile Asn Val Gly Gly 
  1               5                  10                  15
Thr Arg His Gln Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr 
             20                  25                  30
Arg Leu Ala Trp Leu Ala Glu Pro Asp Ala His Ser His Phe Asp Tyr 
         35                  40                  45
Asp Pro Arg Ala Asp Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe 
     50                  55                  60
Ala His Ile Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala 
 65                  70                  75                  80
Asp Val Cys Gly Pro Leu Tyr Glu Glu Glu Leu Ala Phe Trp Gly Ile 
                 85                  90                  95
Asp Glu Thr Asp Val Glu Pro Cys Cys Trp Met Thr Tyr Arg Gln His 
             100                105                110
Arg Asp Ala Glu Glu Ala Leu Asp Ser Phe Gly Gly Ala Pro Leu Asp 
         115                120                125
Asn Ser Ala Asp Asp Ala Asp Ala Asp Gly Pro Gly Asp Ser Gly Asp 
     130                135                140
Gly Glu Asp Glu Leu Glu Met Thr Lys Arg Leu Ala Leu Ser Asp Ser 
 145                150                155                160
Pro Asp Gly Arg Pro Gly Gly Phe Trp Arg Arg Trp Gln Pro Arg Ile 
                 165                170                175
Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Tyr Ala Arg Tyr Val 
             180                185                190
Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser Ile Thr Thr Phe Cys 
         195                200                205
Leu Glu Thr His Glu Arg Phe Asn Pro Ile Val Asn Lys Thr Glu Ile 
     210                215                220
Glu Asn Val Arg Asn Gly Thr Gln Val Arg Tyr Tyr Arg Glu Ala Glu 
 225                230                235                240
Thr Glu Ala Phe Leu Thr Tyr Ile Glu Gly Val Cys Val Val Trp Phe 
                 245                250                255
Thr Phe Glu Phe Leu Met Arg Val Val Phe Cys Pro Asn Lys Val Glu 
             260                265                270
Phe Ile Lys Asn Ser Leu Asn Ile Ile Asp Phe Val Ala Ile Leu Pro 
         275                280                285
Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser Ser Lys Ala Ala Lys 
     290                295                300
Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe Val Arg Ile Leu Arg 
 305                310                315                320
Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu Arg Val Leu Gly His 
                 325                330                335
Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu Leu Ile Ile Phe Leu 
             340                345                350
Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile Tyr Tyr Ala Glu Arg 
         355                360                365
Ile Gly Ala Gln Pro Asn Asp Pro Ser Ala Ser Glu His Thr His Phe 
     370                375                380
Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val Val Thr Met Thr Thr 
 385                390                395                400
Leu Gly Tyr Gly Asp Met Tyr Pro Gln Thr Trp Ser Gly Met Leu Val 
                 405                410                415
Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr Ile Ala Met Pro Val 
             420                425                430
Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr Ser Leu Ala Met Ala 
         435                440                445
Lys Gln Lys Leu Pro Lys Lys Lys Lys Lys His Ile Pro Arg Pro Pro 
     450                455                460
Gln Leu Gly Ser Pro Asn Tyr Cys Lys Ser Val Val Asn Ser Pro His 
 465                470                475                480
His Ser Thr Gln Ser Asp Thr Cys Pro Leu Ala Gln Glu Glu Ile Leu 
                 485                490                495
Glu Ile Asn Arg Ala Asp Ser Lys Leu Asn Gly Glu Val Ala Lys Ala 
             500                505                510
Ala Leu Ala Asn Glu Asp Cys Pro His Ile Asp Gln Ala Leu Thr Pro 
         515                520                525
Asp Glu Gly Leu Pro Phe Thr Arg Ser Gly Thr Arg Glu Arg Tyr Gly 
     530                535                540
Pro Cys Phe Leu Leu Ser Thr Gly Glu Tyr Ala Cys Pro Pro Gly Gly 
 545                550                555                560
Gly Met Arg Lys Asp Leu Cys Lys Glu Ser Pro Val Ile Ala Lys Tyr 
                 565                570                575
Met Pro Thr Glu Ala Val Arg Val Thr 
             580                585



<210> 9816
<211> 1604
<212> DNA
<213> Homo sapiens
<308> NM_004976
<400> 9816

ggggcgcgg  ccagcgaca  ccatgggag  ggccgccag  gggagttgg  gccggggag  60
ggggcgcga  gggccaagg  gacgagagc  agcgcatcg  gatcaacgt  ggcggcacg  120
gccaccaga  gtaccgctc  accctgcgc  cgctgcccg  cacgcggct  gcctggctg  180
cggagcccg  cgcccacag  cacttcgac  atgacccgc  tgctgacga  ttcttcttc  240
accgccacc  cggcgtctt  gcgcacatc  tgaactact  ccgcacggg  aagctgcac  300
gcccagccg  cgtgtgcgg  ccgctctac  aggaggagc  ggccttctg  ggcatcgac  360
agaccgacg  ggagccctg  tgctggatg  cgtaccgcc  gcaccgcga  gccgaggag  420
ctctggaca  cttcggcgg  gctcctctg  acaacagcg  cgacgacgc  gacgccgac  480
gccctggcg  ctcgggcga  ggcgaggac  agctggaga  gaccaagcg  ctggcgctc  540
gtgactccc  ggatggccg  cctggcggc  tttggcgcc  ctggcagcc  cgcatctgg  600
cgctcttcg  ggacccgta  tcgtcccgc  acgcgcggt  tgtggcctt  gcttccctc  660
tcttcatcc  ggtctccat  accaccttc  gcctggaga  ccacgagcg  ttcaacccc  720
tcgtgaaca  gacggagat  gagaacgtt  gcaatggca  gcaagtgcg  tactaccgg  780
aggccgaga  ggaggcctt  cttacctac  tcgagggcg  ctgtgtggt  tggttcacc  840
tcgagttcc  catgcgtgt  atcttctgc  ccaacaagg  agagttcat  aagaactcg  900
tcaacatca  tgactttgt  gccatcctg  ccttctacc  ggaggtggg  ctgagcggc  960
tgtcctcca  ggcagccaa  gacgtgctg  gcttcctgc  cgtcgtccg  ttcgtgcgc  1020
tcttgcgca  ctttaagct  acccgccac  ttgtgggcc  gcgggtcct  ggccacacg  1080
tccgagcca  caccaacga  ttcctgctg  tcatcatct  cctggcctt  ggcgtgctg  1140
tcttcgcca  catgatcta  tacgccgag  ggatagggg  acagcccaa  gaccccagt  1200
ccagtgagc  cacgcactt  aagaacatc  ccatcggct  ctggtgggc  gtggtcacc  1260
tgacgaccc  gggctatgg  gacatgtac  cgcagacgt  gtccggcat  ctggtgggg  1320
ctctgtgtg  gctggcggg  gtgctcacc  tcgccatgc  cgtgcccgt  atcgtgaac  1380
atttcggga  gtattactc  ttagccatg  ctaagcaga  actaccaaa  aaaaaaaag  1440
agcatattc  gcggccacc  cagctggga  ctcccaatt  ttgtaaatc  gtcgtaaac  1500
ctccacacc  cagtactca  agtgacaca  gtccgctgg  ccaggaaga  attttagaa  1560
ttaacagag  aggtaggaa  cctctcaga  gcatgtcga  ctga  1604



<210> 9817
<211> 511
<212> PRT
<213> Homo sapiens
<308> P48547
<400> 9817

Met Gly Gln Gly Asp Glu Ser Glu Arg Ile Val Ile Asn Val Gly Gly 
  1               5                  10                  15
Thr Arg His Gln Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr 
             20                  25                  30
Arg Leu Ala Trp Leu Ala Glu Pro Asp Ala His Ser His Phe Asp Tyr 
         35                  40                  45
Asp Pro Arg Ala Asp Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe 
     50                  55                  60
Ala His Ile Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala 
 65                  70                  75                  80
Asp Val Cys Gly Pro Leu Tyr Glu Glu Glu Leu Ala Phe Trp Gly Ile 
                 85                  90                  95
Asp Glu Thr Asp Val Glu Pro Cys Cys Trp Met Thr Tyr Arg Gln His 
             100                105                110
Arg Asp Ala Glu Glu Ala Leu Asp Ser Phe Gly Gly Ala Pro Leu Asp 
         115                120                125
Asn Ser Ala Asp Asp Ala Asp Ala Asp Gly Pro Gly Asp Ser Gly Asp 
     130                135                140
Gly Glu Asp Glu Leu Glu Met Thr Lys Arg Leu Ala Leu Ser Asp Ser 
 145                150                155                160
Pro Asp Gly Arg Pro Gly Gly Phe Trp Arg Arg Trp Gln Pro Arg Ile 
                 165                170                175
Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Tyr Ala Arg Tyr Val 
             180                185                190
Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser Ile Thr Thr Phe Cys 
         195                200                205
Leu Glu Thr His Glu Arg Phe Asn Pro Ile Val Asn Lys Thr Glu Ile 
     210                215                220
Glu Asn Val Arg Asn Gly Thr Gln Val Arg Tyr Tyr Arg Glu Ala Glu 
 225                230                235                240
Thr Glu Ala Phe Leu Thr Tyr Ile Glu Gly Val Cys Val Val Trp Phe 
                 245                250                255
Thr Phe Glu Phe Leu Met Arg Val Ile Phe Cys Pro Asn Lys Val Glu 
             260                265                270
Phe Ile Lys Asn Ser Leu Asn Ile Ile Asp Phe Val Ala Ile Leu Pro 
         275                280                285
Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser Ser Lys Ala Ala Lys 
     290                295                300
Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe Val Arg Ile Leu Arg 
 305                310                315                320
Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu Arg Val Leu Gly His 
                 325                330                335
Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu Leu Ile Ile Phe Leu 
             340                345                350
Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile Tyr Tyr Ala Glu Arg 
         355                360                365
Ile Gly Ala Gln Pro Asn Asp Pro Ser Ala Ser Glu His Thr His Phe 
     370                375                380
Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val Val Thr Met Thr Thr 
 385                390                395                400
Leu Gly Tyr Gly Asp Met Tyr Pro Gln Thr Trp Ser Gly Met Leu Val 
                 405                410                415
Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr Ile Ala Met Pro Val 
             420                425                430
Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr Ser Leu Ala Met Ala 
         435                440                445
Lys Gln Lys Leu Pro Lys Lys Lys Lys Lys His Ile Pro Arg Pro Pro 
     450                455                460
Gln Leu Gly Ser Pro Asn Tyr Cys Lys Ser Val Val Asn Ser Pro His 
 465                470                475                480
His Ser Thr Gln Ser Asp Thr Cys Pro Leu Ala Gln Glu Glu Ile Leu 
                 485                490                495
Glu Ile Asn Arg Ala Gly Arg Lys Pro Leu Arg Gly Met Ser Ile 
             500                505                510



<210> 9818
<211> 2858
<212> DNA
<213> Rattus norvegicus
<308> X62841
<400> 9818

gtgcgcttc  ctgtctttc  ggggttggg  ggggcgtgt  cccggcccg  agcatcctt  60
tgcttgcct  aaccttctg  gaccccgga  cccttggat  gagtcctcg  ccctggtct  120
cacctcctg  ctcccctag  ttcttcctg  caaatccca  ccacctgtg  accacaaaa  180
gccaactct  cctgctccg  gccccgggg  ggtggggtg  gggggaggc  ggggcagag  240
cactctgca  aaggggccg  caccacctc  tgcctcctc  tcctccacc  cctcctcct  300
cttctcgtc  cctccccct  cccgttctg  cgctgcctc  ttgggaagg  tgtttggag  360
gcagcggcc  ccccaagcc  gagccccgc  gcgcttctt  tgatcagct  ggtgtgtgt  420
tcctcctac  gcgggcgca  gtcggggaa  aagcctccg  ccaaaacat  tctgaagga  480
gagatggcc  agggcgagg  gtcggagaa  atcatcatc  acgtgggcg  cacgcgaca  540
gagacctac  gcagcaccc  gcgcaccct  ccgggcacc  gccttgcct  gctggcgga  600
cccgacggc  ggggtcggc  agagtcgga  ggcggcggt  caggcagca  cggcagcag  660
ggcggcggc  ggggctgtg  gttcttctt  gatcggcac  cgggtgttt  tgcctatgt  720
ctcaactac  accgcacgg  caagctgca  tgccccgca  acgtctgtg  gcctctctt  780
gaggaagag  tcactttct  gggtatcga  gagacagat  tggaaccct  ctgctggat  840
acctaccgg  agcaccgcg  tgctgaaga  gcactggac  tcttcgaga  cccggacgg  900
ggcgggggt  gcgcagggc  cggcgacga  gctggagac  atgagcggg  gttggcctt  960
cagcgcctg  gcccccatg  aggaggctc  ggccctggt  ctgggtccg  gggttgccg  1020
ggctggcag  cccgaatgt  ggcgctctt  gaggacccg  actcatccc  ggcggccag  1080
gtggtagcc  ttgcctctc  cttcttcat  ttggtctcc  ttaccacct  ctgcctgga  1140
acccacgag  ccttcaaca  tgaccgaaa  gtgacggag  tccaccggg  agggaatat  1200
accagcgtg  gcttccggc  ggaggtaga  acagaaccc  ttcttacct  catcgaggg  1260
gtgtgcgtg  tgtggttca  tctagagtt  ctggttcgc  ttgtgtgct  ccctgatac  1320
ttggacttt  tcaagaacc  gctcaacat  atcgacttt  tggccatct  gccctttta  1380
ctggaggtg  gattgagtg  cctgtcatc  aaggcagct  gagatgtgc  gggtttcct  1440
cgtgtggtg  gctttgtac  catcctgcg  atcttcaag  tcacacgcc  ctttgtggg  1500
ctgcgtgtg  tcggccaca  actccgggc  agcaccaac  agttcctgc  gcttatcat  1560
ttcctggcc  tgggtgtgc  catctttgc  accatgatc  attatgctg  gcgaatcgg  1620
gccaggcca  ctgacccac  gggcaatga  cacaccgac  tcaagaaca  ccccatcgg  1680
ttctggtgg  ctgtggtca  catgacaac  cttggctat  gggacatgt  tcctaagac  1740
tggtcagga  tgctggtgg  tgcgctgtg  gcactggct  gtgtgctaa  cattgccat  1800
cctgtgcct  tcatcgtca  taactttgg  atgtactac  ccctggcta  ggccaagca  1860
aagcttccc  agaaacgaa  gaagcatgt  ccacggcca  cccagcttg  gtcacccat  1920
tactgcaag  ctgaggaga  ttcaccccg  gacagcacc  acagtgaca  cagcccccc  1980
gcccgggaa  agggtatgg  cgagaggaa  cgagcagac  ccaagcaga  tggtgacgc  2040
aatgcggtg  tgtccgatg  ggagggagc  ggcctcacc  agcccctgg  ctcggcccc  2100
acccctgaa  agcgtcgag  cctgagacg  tcaggcaca  gggacagaa  caagaaggc  2160
gctgcctgc  tcctgctca  tgctgggga  tatgcctgt  ctgatggca  tgtccagaa  2220
gaaggcagt  ttgagccga  agcgtgcgt  ccagtgtct  acacctgtg  tctttaaac  2280
cagagacct  ccaagacgc  ctctcgtcc  actatgccc  tgctgaagt  ctcaccctc  2340
cttagagcg  caccaacgt  agaaagaca  acagacaga  agccagagg  ttaggaaaa  2400
tctggaacc  aggcacgaa  cttttgctg  gaaagatat  cttgtttgc  caagactgg  2460
ggaaaaatc  cccatgcaa  tctcagggc  cagagccat  tgggtctga  actctgttc  2520
actgtacat  gaagagaca  atatgcaca  atagtatct  tattcatac  tactatata  2580
tcttgtgtg  agtgcacgt  ctactggtg  tctgtcttc  tcgttaggc  atgtctccc  2640
agtcctctg  ccaccctgt  tccccaccc  ctcttcctt  atggattgt  tcttctgac  2700
atgtttttg  agtgtccca  gagaggtat  cctgggacc  gcccctcca  ctgggtggt  2760
ccaggctgc  ctcacttgg  ggtgtcccc  gccagcagg  ggcctgctg  agtcagttg  2820
aggcacgat  gcccttctg  ggtcactgc  tcactagc  2858



<210> 9819
<211> 625
<212> PRT
<213> Rattus norvegicus
<308> CAA44645
<400> 9819

Met Ile Ser Ser Val Cys Val Ser Ser Tyr Arg Gly Arg Lys Ser Gly 
  1               5                  10                  15
Asn Lys Pro Pro Ser Lys Thr Cys Leu Lys Glu Glu Met Ala Lys Gly 
             20                  25                  30
Glu Ala Ser Glu Lys Ile Ile Ile Asn Val Gly Gly Thr Arg His Glu 
         35                  40                  45
Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr Arg Leu Ala Trp 
     50                  55                  60
Leu Ala Asp Pro Asp Gly Gly Gly Arg Pro Glu Ser Asp Gly Gly Gly 
 65                  70                  75                  80
Ala Gly Ser Ser Gly Ser Ser Gly Gly Gly Gly Gly Cys Glu Phe Phe 
                 85                  90                  95
Phe Asp Arg His Pro Gly Val Phe Ala Tyr Val Leu Asn Tyr Tyr Arg 
             100                105                110
Thr Gly Lys Leu His Cys Pro Ala Asp Val Cys Gly Pro Leu Phe Glu 
         115                120                125
Glu Glu Leu Thr Phe Trp Gly Ile Asp Glu Thr Asp Val Glu Pro Cys 
     130                135                140
Cys Trp Met Thr Tyr Arg Gln His Arg Asp Ala Glu Glu Ala Leu Asp 
 145                150                155                160
Ile Phe Glu Ser Pro Asp Gly Gly Gly Gly Gly Ala Gly Pro Gly Asp 
                 165                170                175
Glu Ala Gly Asp Asp Glu Arg Glu Leu Ala Leu Gln Arg Leu Gly Pro 
             180                185                190
His Glu Gly Gly Ser Gly Pro Gly Ala Gly Ser Gly Gly Cys Arg Gly 
         195                200                205
Trp Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg 
     210                215                220
Ala Ala Arg Val Val Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser 
 225                230                235                240
Ile Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile Asp Arg 
                 245                250                255
Asn Val Thr Glu Ile His Arg Val Gly Asn Ile Thr Ser Val Arg Phe 
             260                265                270
Arg Arg Glu Val Glu Thr Glu Pro Ile Leu Thr Tyr Ile Glu Gly Val 
         275                280                285
Cys Val Met Trp Phe Thr Leu Glu Phe Leu Val Arg Ile Val Cys Cys 
     290                295                300
Pro Asp Thr Leu Asp Phe Val Lys Asn Leu Leu Asn Ile Ile Asp Phe 
 305                310                315                320
Val Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser 
                 325                330                335
Ser Lys Ala Ala Arg Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe 
             340                345                350
Val Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu 
         355                360                365
Arg Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu 
     370                375                380
Leu Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile 
 385                390                395                400
Tyr Tyr Ala Glu Arg Ile Gly Ala Arg Pro Ser Asp Pro Arg Gly Asn 
                 405                410                415
Asp His Thr Asp Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val 
             420                425                430
Val Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Lys Thr Trp 
         435                440                445
Ser Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr 
     450                455                460
Ile Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr 
 465                470                475                480
Ser Leu Ala Met Ala Lys Gln Lys Leu Pro Lys Lys Arg Lys Lys His 
                 485                490                495
Val Pro Arg Pro Pro Gln Leu Glu Ser Pro Ile Tyr Cys Lys Ser Glu 
             500                505                510
Glu Thr Ser Pro Arg Asp Ser Thr Tyr Ser Asp Thr Ser Pro Pro Ala 
         515                520                525
Arg Glu Glu Gly Met Val Glu Arg Lys Arg Ala Asp Ser Lys Gln Asn 
     530                535                540
Gly Asp Ala Asn Ala Val Leu Ser Asp Glu Glu Gly Ala Gly Leu Thr 
 545                550                555                560
Gln Pro Leu Ala Ser Ala Pro Thr Pro Glu Glu Arg Arg Ala Leu Arg 
                 565                570                575
Arg Ser Gly Thr Arg Asp Arg Asn Lys Lys Ala Ala Ala Cys Phe Leu 
             580                585                590
Leu Ser Ala Gly Asp Tyr Ala Cys Ala Asp Gly Ser Val Gln Lys Glu 
         595                600                605
Gly Ser Val Glu Pro Lys Ala Cys Val Pro Val Ser His Thr Cys Ala 
     610                615                620
Leu 
 625



<210> 9820
<211> 31737
<212> DNA
<213> Homo sapiens
<308> AL137790
<400> 9820

gatccgagg  ttgcttctc  gaggacctg  ttacccaca  tgcctccat  tcctcccct  60
tgcctctct  ttttcttca  ttcccctgg  ttcttgcca  ggagcaact  cgaggaagc  120
tctgaagcc  cctgtggcc  cctgcgtgg  ctccctcag  gtctttcac  ggcagcact  180
acccttcct  ctccaggct  tgggttttc  tcttgcctc  gctgcttct  cttctctga  240
tccctttca  gagactctc  ctcttccct  cattcagtg  tggagatag  agcaggctt  300
tgcttctta  ccctctgta  ctacagcca  agcctcagc  cctgccagc  cacctgcta  360
tcagaaagt  tatctccag  ttgtctctc  ctggctcca  gctcatctg  ccagcggac  420
acttggcat  tcattttag  tgtcttaaa  acacattca  ctcaacctt  gtagaacta  480
tgtcctgat  ctccctgcc  aacaccatc  acctgttcc  ctcccactg  ccccatctc  540
acctgctca  gtatgcagg  cagagacat  gccctcacc  cggcctctc  ctctccagc  600
tctcccatc  ccagtccat  ccgaaggtc  ccttggttt  tcctgcgaa  atctctcca  660
tggcaccac  cagcccctt  gcaaagcca  tgtcccctc  agcctggac  ccagaagcc  720
cttccttga  ggtctgctg  atccactta  ttcttttgg  aatgcacat  attgtgtcc  780
cacttcttt  aacccctcg  tggcttctt  ggttaggtg  tttcttagg  tgaagacag  840
atctgtaca  gcctttgat  taacttctc  cctctccca  ccctacctg  gccaccccc  900
cctcgtcct  actgcttca  ccaccctgg  accttccat  cccttttac  caccatcct  960
tgtcctatc  caggacctc  gtccatgct  cttcccgaa  gttcttccc  ccccttgtg  1020
cctcgcttt  atcagcttt  aaatgtcag  ttgaggacc  cttcttctg  gaagccttg  1080
ctggcctcc  aacttgttc  gatcccctt  ttatgggct  tccaagcac  gggtgccca  1140
ccttcacag  ccttgtcac  tttgcaatt  agcatttgt  cgtgggatc  tttgaccaa  1200
gtgtctctc  ccaactaga  tgtaaactt  gagagcctg  ttgcttcta  tccccatgg  1260
ctctgcatc  cctagcacc  ggcctggcc  acagcaggt  ctcagagat  gatggatga  1320
tggctacat  tcattgcca  agggaggcc  tgacacctt  tacctaata  gtacacagg  1380
gtgggctgg  gagagggtc  cctcataga  gccaagggg  ccttagatc  ttaaggcct  1440
ggttctggg  tttcttggt  gactaaaga  ggttttact  attttgtgc  ggatggggg  1500
ccttaatct  ccctggagt  cacatgctg  ctgaccagg  agtcctcct  ggtctccat  1560
tgtgcccag  ccctgaagc  caaaggctc  actaccatc  cccacctct  tcccctcag  1620
atgggggtg  cgccctcag  ctcactgct  tgccagcgc  ctgagcttg  caacatctc  1680
gctgttgga  tgctgccag  agttgagac  tgcctagga  gctgctgag  tgatggcag  1740
tgggccctg  gtcctggat  ttatttagg  ctgtgatat  aaagacagc  aaagtccag  1800
cggacccta  agtccaaca  ctcactgtt  aggtgagga  ttacccaca  gtactcaga  1860
ggggcagcc  ggccaggac  cacacaggg  ttgtcacca  agggaagtg  actctctga  1920
ttggctcct  gcctcctta  tctgtctgg  gtgaggtca  ttaggttca  ctcagcagc  1980
aaggtcaca  gggaaaatg  tttaaagag  ataggtgat  gaaaaactg  gtcaggagt  2040
ggtgctggg  ccgggggcg  gggcctggc  cagaatatc  atattttag  tatcactct  2100
ccccgacta  ccagctcca  taccttgag  aagtcattt  atctttggg  tctcagttt  2160
ccctttaaa  acatgaata  taatccttg  ttcctgcac  cccgcaaaa  acaaaacac  2220
ctgtcctga  gaggtcagc  tcattctgt  gggattgag  gccactacg  acaggcatt  2280
cttgttgct  tacatttga  cctcacgtt  actccgaga  tctattact  ttccctttt  2340
ttcagatga  taatctgaa  ctcataaca  agtcagtgc  acttaccaa  agcttcata  2400
ccatttaaa  atgggagtc  ggatttgga  ctggatctg  ctgagactc  aaagctctg  2460
gctgggtcc  aggcttggt  cctgcccca  ggaacaaac  ataaaagga  aataggttg  2520
aaaggggct  tggaaattg  tccatgcca  cccaatgct  ttgcagttc  ggctcctgt  2580
aggtgtgag  gcagatgga  gcttaggcg  aggcccttt  tccaggaat  gtctaggtt  2640
tgtgcttca  gttgggtga  ggtggggaa  agcaggcgg  ttgggtttt  tttcctttc  2700
tgaggtaga  gagtttgag  tggagaagg  gtcagggag  ttctggtat  ctcagtttt  2760
ttgtgctgc  gtgcaagct  ttcactgca  gactctagg  ggcacctgt  acactgtag  2820
ccaagtgaa  ggcactctc  agagctgtg  actacatga  catatgtga  ggccttgac  2880
atgttcctt  gtatgatgg  tgcatggga  gccatggta  cagttaaat  actatgtaa  2940
cactcagca  ttatgttgt  ttaccaagt  ctcacagtc  tcctctgaa  ttgatactc  3000
tgtgatctg  gtattgggg  aactgaggc  cagaggagt  gggaaattg  ccaagttca  3060
acagcttct  accactatg  gctgctgcc  ctgaactct  ttgaggctg  gaaaggggg  3120
gtgcacatg  ataaaacca  cccctctgt  tctcttttc  tcctcctgc  ttggtcttc  3180
gccatagct  gacaagatg  tggaccccc  ggtgtggcg  gaggcagct  cccaggtct  3240
ctttgcctt  ggcctgggc  ttggtggtg  cattgcctt  tccagctac  ataagcagg  3300
caacaactg  cacttcgat  ccgccctgg  gtccttcat  aacttcttc  cgtcagtgt  3360
ggccaccct  gtggtgttt  ctgtgctgg  cttcaaggc  aacatcatg  atgagaagt  3420
tgtggtcga  taggtggca  ctctcctcc  gtccctcct  ctccctgtc  accttacct  3480
ggagtgggc  ggggtgggg  cgcaggtgt  catggggag  gaggtcccc  ccactcaga  3540
tgaggaatg  agatcagag  agcactctc  gtccccagc  ccgggccac  gggacaagc  3600
cagagatgc  tctgtcagt  acccatgag  ttcccacct  ggtgcctgg  aagagcctc  3660
aggatctca  ccattgccc  cccctgcct  cttacctgg  cctctcggt  ttgtgctgc  3720
ggaatgctg  gaaaatcct  gggtacctt  acaccaacg  cctgagccg  gacctcatc  3780
caccccacg  caacttctc  cacctgacc  caaaggact  catggagat  tacaatgtc  3840
tcatgaccg  gaaggagga  cagttctca  ccctgggcc  tgacccctg  cttctggag  3900
acgagctgg  caaggtgcg  ggacaggct  cccttccca  gacaggcag  aacccagag  3960
gcagctgtg  ccggcggga  cttgggctc  ggcctcagg  tgctgacag  tagtcatta  4020
tttacttgg  aagcaagga  ctgctgtgt  tccagaggg  gtgaaaggg  agaaaggta  4080
tggccaaag  ccctgccca  aggtaggct  gagcctaga  aagaagtag  gcagacaca  4140
acctctcag  agtcacagt  agtgtatgg  acgatgttt  catttactg  gtgggcttc  4200
cgtgcatca  tcactgcca  aggtaatat  ctcagaaca  tgccttgac  tggtgtgca  4260
caaagaagt  ttgaagtta  tgtttgccc  ttgctgtct  tctcttttg  cgctcaaga  4320
agctctatg  gttgagtat  catattgtt  cctacctta  agatgagta  cctatgaga  4380
ggggggctt  atcaaggtc  cataactag  aagtcagag  ggcagttag  tgggtccaa  4440
tccagttag  tgggtccag  gcccatgct  aggatcacc  cttgatgct  ctgcccctc  4500
ccaacctgt  cccattcca  tctcactgc  atgatgact  ttagacttt  gggtggtgc  4560
gggggtgct  actcctcct  agtgctcag  cccatgtta  gacaccttg  ttctattta  4620
acttacata  ctggacact  tcaaaatga  tgttctgtt  gaaggggta  caggaaagg  4680
acataccca  agcatcttg  gaaccaggc  ggagccaag  ctcacatgg  gcggagcca  4740
ctcccatca  cctgggtca  ccctgtcct  catgggact  gggaagggg  tgctttccc  4800
gggctctat  ttaaaagtc  gctccattg  atggtacca  cctaatgct  agggagctg  4860
atcctacac  ccaaccctt  ccctgcgga  caagagcaa  agagcccaa  ctcgggccc  4920
ctgccctgg  ttcttcccc  ggtaactgg  agcataaag  acctcccct  ttcacattc  4980
ctgaaaccc  gctcagttc  catgggcat  gcctggttc  ctgaattaa  ctaggttta  5040
agcagtgtt  tcatacaat  caactccga  agcattcaa  tgacaagat  atacactca  5100
ttagtgggg  agaaatgtt  ccttacaat  actgaacat  acagggcaa  gtgtaagtg  5160
cagggggca  tgtgtggtc  cctgaccca  aagcatggc  caagcatta  agcagtgat  5220
ctctacctt  gctacccat  agagttcct  gggtatttt  gtttgtttt  aaaaaaaac  5280
ctgacaccc  gcttcaccc  agaccaatc  agtcattgt  cgtggggtg  gacccaggt  5340
tcggtgttt  taaaggctc  ggtgtgctt  cattgagag  cgaggctga  accactgca  5400
gaagatctg  agttcagaa  ttctgagct  ggagcggcc  cagtgtggc  ggagcaatc  5460
ggaaagaca  cttagagga  cagggtcct  agctgggtg  atttctaaa  atgagcatc  5520
tcacttgaa  cacctaagc  cctggtaca  cccgtagat  ccaggtccc  caggtgaac  5580
cccaagttg  tgtttttga  ctacgtcta  gggattcca  tgcctgcta  agttcgaga  5640
ccactggcc  aaatcaaca  gatttaggt  gaggtggga  cccctgtga  agagggaat  5700
gttattcca  aagtttgaa  ggcagaggg  aggaagcag  gggctcccc  gggaggggt  5760
acctcacag  ccctgcttt  caccccacc  tcagtccgt  cagggcaca  gcctggcct  5820
catcgcctt  actgaggcc  tgacgcact  ccccgcctc  ccgttctgg  ccgtcatgt  5880
cttcttgat  cttatcaac  tgggcctgg  cagcatgat  gggaccatg  caggcatca  5940
cacgcccat  atcgacacc  tcaaggtgc  caaggagat  ttcacaggt  actcctccc  6000
gcccccatg  ccaggctct  caggctgcc  ttgtggaca  caattccgt  ctggcttct  6060
actgggtcc  tcatgaccc  acacccaga  ggctccacc  cacactggg  cacagctgg  6120
gcctggctg  gccactcag  gattagcac  cacaagcca  gaagagaaa  ctacttgga  6180
atctggagc  aacatgagc  gggaggcct  catctaggc  cctttgtta  ttcacttgc  6240
cctctcccc  agggcctgc  gagtcgtct  gggaagtgg  tgctgagtc  tcttgggca  6300
gggcactca  tggccttgc  ccctgttcc  tctttgtca  tccagtccc  ggctgtgtc  6360
acagttccc  tcggggttt  ctgcgttga  ctagggccc  tagagggat  cctctcatc  6420
gcatcccta  agcggggta  ctttctgtt  tcaagtggg  aaactgagg  ggagaaaaa  6480
actggtaac  atcagatga  tcatttaag  taaatacag  aattaagta  cgcacctgc  6540
acgggccag  ccctgtgct  gggcagagg  atgggatga  agttagaca  aacgccttc  6600
tcaggtgct  cccgactag  agagcgggg  tcagaacct  agcatctgg  tccctcgtg  6660
aggactgag  ctgctggca  gagggctgc  ggcatgctt  ggggaggga  gtgatggga  6720
gggcctggg  gcccccgag  cccccaggg  cctgcccac  ctgcacctt  gcccccaaa  6780
cggcctccc  gctctctgt  gtgggctgc  gtgtctttg  attcctcgt  gggctgttg  6840
tcgtccagc  ctccggaaa  tactttgtc  ccatgttcg  tgactactc  gccaccctg  6900
cactcactc  catcgtcat  cttgagaac  tcgctgtgg  ctggattta  ggaaccaag  6960
agtaagagg  acatggggg  aaggtggga  gggaggagg  gtctgtcct  tcatgactc  7020
ctggagagg  agatcatag  gtcacaatg  cagagctga  agtgccctt  cggatcatt  7080
agggaaact  aggtgtagt  caaggacat  gctgcctaa  gccacttgt  cagggagaa  7140
cagagccag  ctgaggact  ggtgtcctg  gtgcaggtc  tggcatcat  cttaaatta  7200
cacagcacc  ttcctgggt  ccaactctt  agaactctg  taagttttt  tgaagggct  7260
agtgggtct  caagaggcc  ttgccctcc  agaacgtgt  gacttcagc  gcctggttc  7320
caattgtaa  ggcctagat  ggggtatga  atgaggtat  attttggcc  caagtttgg  7380
gttgtgcag  gtaagagga  tcagctcta  gaaaggatt  ggtctcaca  cctaggcct  7440
gggcagttg  acacttact  taaactctt  gcctcatcc  tcatgttag  gcaaatacg  7500
gttcccagg  gttctagaa  taggtctct  tgactcact  agcatcgac  atgaccaca  7560
tgtccttgt  cttggcaag  cccacctcc  ctaacccac  tggtctgac  ctccctgat  7620
cctggacct  gtttggcag  ggggctctt  cacaggggc  gtctgcttc  taggagagc  7680
caggagggg  cagggagtg  ggggaagga  actcctctg  ttccacctg  tgtgggcca  7740
ggctgtaag  cactgccac  aaggactct  gctgatttt  gtgtcctgg  ctccttcgg  7800
agtctggtg  tgtccctgt  tgttacttt  aatgcataa  ataaaatgt  tagggttat  7860
taagaaact  attatattg  aaaatagca  aatatcatt  aaaatttgt  atatagtaa  7920
gtatgagca  tttattttt  atgcattgt  acaagatct  gctatagat  taataacag  7980
ggtaacttt  aagtagtga  gaaaatcag  gatgactca  tattttcaa  aactgggat  8040
taatatgaa  atatctgta  tctattggt  acagtcaca  gtattgtta  tactactgt  8100
tttgcttgc  ttcataata  aatagaaag  aatgcaaga  tttagttag  ggttattga  8160
gtaaagatg  ttcttttgt  tgccattca  gcacaagcc  gcctgcctt  cagaattct  8220
ctcacccct  ggtgagaaa  ccctgagtc  gggcagctc  ctacctttg  actctagag  8280
agtgcactt  tactgcttt  ccagcaggg  gagccttca  ccaggccag  gtgaaaggg  8340
taggcccct  cctgaacac  caagctgtc  atacataaa  cagacgtgc  cctgcccag  8400
gtgtgtctg  tgggcccta  catatctct  gatggggta  gatgtgacg  aatcagaag  8460
ggttagagg  ggacagtag  gccttccca  aggccagcc  gaccacaca  aatgagcac  8520
gaatgtgaa  aatagaaga  cccaggagg  agggactgg  aaacgaaga  tttctggag  8580
agatggtga  gggggaaga  ggaggtgtg  ctgagggat  ccaactgct  gaccctctg  8640
tatgcctgg  aggttcatg  aggagctga  ggagatgct  ggcttccgc  cctaccgct  8700
ctatttcta  atgtggaag  tcgtgtctc  actatgcat  gctgtgctc  ccacagcca  8760
catcatcca  ctgggggtc  cgcccccgg  ctacagcgc  tggatcaag  aggaggtga  8820
gggtggggc  ccaaacccc  gggacattt  catcttctc  ggccttgaa  gcaaccact  8880
atagggata  acctttcta  ggcagctgc  atgtgccag  ccttgccag  tgcctcaca  8940
ctaaaccgc  atcttacaa  aagccaaag  cagaggtgg  atcatccct  tagcacaaa  9000
ggggacacc  aggctcaga  agattaatg  acttatcca  tctttctaa  ccatattct  9060
tctccatgc  tgtggagtg  aattagtcc  ttttatagt  ggagaaacc  ccctagacc  9120
tttcaccaa  gtgaccagg  aaaccccca  ccttggctg  gcctggcca  gatggtggg  9180
ggggagagg  gtggaaggc  atgggtgag  gcaggagag  agtcttgga  ggcctgggc  9240
gggagggct  tcacagtgc  ggcagcagc  cttaaggca  cccacccgc  ggctgccga  9300
cgctacctg  atttcccca  ctgggccat  gcactcctg  tcaccctca  cgtcgtggc  9360
acgctgccc  tccctgtgg  gttcgtcct  cggcacttc  acctgctct  tgatggctc  9420
aacaccctc  ccgtgtcct  caagaaggg  cgcatgatg  aggacatct  caacctgga  9480
gagaacgat  agacccgct  catcctcag  aaggtgccc  gtgaggcac  ttcccccat  9540
cccactcac  gttcctatc  ggggcccgg  agcacatca  ccctggaga  cagcggtaa  9600
cccaatgga  gctatggga  cggctacct  ctggccagc  cccctgagt  ggagctgtg  9660
ccactgccc  agccctgcc  gcctctccc  ccacgctca  cctgcccac  tgtccaggc  9720
tggcctctt  cttgaggtg  ccaccaggc  caggccagg  cctttgccc  agaagagag  9780
gtctgccct  cctcactcc  ctcttcagt  ccagtagac  ctgctccct  gccctgagc  9840
ggaggctgg  agcagctct  tttcctaat  caggacccc  ctcatctag  cctccaaga  9900
cctccgcca  attgtagcc  tgtaattgg  acaacccat  aggcctgct  cccagtcca  9960
gggagattc  aagtggcca  tgcaggagt  actcacctc  ctctctccc  gtaacttgc  10020
acctgcagt  cttagggct  tggggtcag  tggtggtgg  gagaggcct  ggggctggg  10080
aaggagagt  gactttggc  cactctgcc  tgagaacag  acaccatcc  gcccagccc  10140
gacggggtt  ctcctggtc  aagaggcta  ctgctccaa  gcggagggt  ggagcaggt  10200
tgccagggc  cagggctca  acttgggag  gcctaggca  aagccccaa  ttctgtttt  10260
tgaggtatg  gctgccctt  gcttcagca  gagccttgg  agcagaagg  gaggaacct  10320
ctctgccct  gtccctggg  ggaatcttc  catgtcctt  gccctgcct  gggtgtgtg  10380
tgtgtgctc  tgcatcttg  ctgggagtg  agtgaccgg  accagaacc  tccccacct  10440
aattagggc  tagccatct  cctgtcccc  gcacccctc  ccagcccac  gtggtggcc  10500
ctgcctctt  cctggagag  gaaggacag  gcacggaga  gtttccaga  cacaaattg  10560
tggttccta  cacaaatta  atggtttgg  gcacaatgg  gaagcacac  cccctccct  10620
ctcacctgg  gtccaatgt  ctgtctagt  gcagctttt  ccctggaac  ggggtccct  10680
gagttcaca  gcttatccc  aggaagcct  actcctggg  aaagacaga  aatttcact  10740
cccctttga  ccaccactc  ctctcctta  tacacaagc  cagccgccc  gtgtgcaca  10800
catgtgcag  caccttgga  acctttccc  agccttcct  gcccacagt  gccagtgcc  10860
taggcagtg  tgtggacag  agaggctgc  aaaggcaag  gctggtctt  aggatggag  10920
ccagcctgt  cagaaggct  cagctgaca  cagcgaccc  acctgccat  accttcagg  10980
cctcctctg  aagagaacc  attctcaga  tgcagccag  gaggaacct  acccaagag  11040
aaatgtctg  agagagatg  atggatgga  ggatagatg  atggatggg  tggggagtg  11100
gggtggatg  atggataga  ggatggatg  atggatgga  gggttgggg  gtgggggtg  11160
atggataga  ggatggatg  atggacgga  ggggtgggg  aaggaagga  aggagggag  11220
aaggaggga  tactggctc  atctttgag  gctctggtg  gcagggcag  aacaggcca  11280
agtgctcaa  ccggacacc  tcacgaagg  tcgcaagtc  ctcttgtgg  tcagattgc  11340
cttaggacc  ggagggaca  accagaatc  gggtcccct  ctttacccc  gagttcctt  11400
ctgttcccc  aagcctggg  gcagtctat  ccccaaccc  gccatctcc  ttactcatc  11460
ctcttccac  gcttcccct  tctagcccc  tctgcccta  ctgtctttc  tgagtgttt  11520
aggggagag  gagacccac  tctccccaa  gagatgagc  tttggggca  aacatccca  11580
cgcagtccc  ctcacccga  aacacctcc  acctggccc  ttgccaaat  ccaagcaga  11640
ttagcaaca  gaaaagcag  gccccagga  agacactct  ctatatata  tcttctata  11700
attctgttt  tattgtata  tcactctgt  catgtgggt  taaatgctg  taaatgaca  11760
acccaatat  atactgtgg  tggtggact  ttttcatcc  cagtgctgt  cagatctat  11820
ttcattgta  atttgatat  tttttaatt  tgtagcgtg  ggctgggcc  ggccccagc  11880
ggaggggct  agctggggc  gtgtgcttg  taggtgtgg  cgcgctagt  ctcgttgta  11940
ccttttgct  tgtcttcgc  gtgtgttag  cgtagggcc  agagctcgg  gtgtgtgtg  12000
gcgtgctgt  tgtatggtg  gcacatacg  gagtgtggg  gtgtgtagc  tgctgatct  12060
tgactccca  tgttcacca  cttcctgaa  accacgctc  ctccccctg  ctcctcctc  12120
tcctcttgg  tctattggg  gcctcaggg  cggcagggt  cttcgggag  cccctgcta  12180
ggggaaagg  atgtgtttc  tgctggtga  tcattgcct  cacaccact  ggtttgcca  12240
aaacaggga  ggagggcgt  aagggaaaa  aaaaatcct  aaatttatt  accagtcag  12300
ttcttgctg  tcccagtag  atcgctagc  cttctccag  ggaaaagta  taggattct  12360
aagatggcg  gaccccaag  gggatctca  agcactgct  catttgccg  tgacgcagt  12420
ctgacagtg  ttgaaaagg  ccgcctgcc  cctccccac  gtgcttttg  tgcctttgg  12480
gtcaaaggc  ggtggggtc  cctgatgag  taagatcca  ccccagaat  ctggaggag  12540
aggaggtag  aggagagga  caggtcccc  agtcccttc  cagggtccc  acccccact  12600
gctttggtg  tgtccacac  gtgcccacc  gaaggcaga  ggaactcca  ggcagggat  12660
tgcctgaaa  agtcaacag  cccctgatc  cctacctct  cctgccctc  agccccatc  12720
ccagcttct  gctcaggga  acttccgcc  tcctcactg  ggcaacatg  agcccgagg  12780
ccagatggg  gctgaacag  tagggcaca  cagttaatg  cagtgaggt  agcttctgc  12840
ctccagcaa  acatgtgca  gggttgctg  tttcccagt  ccaggagaa  ccccgctcc  12900
agtcagcct  tgtgggtca  gaggctggg  cccaggaga  acggtccca  gcactgcac  12960
ggcctgcag  attaccagg  ggaggggct  cttttctgc  cttcctcac  cccacgccc  13020
accccactc  cccagagta  tccccactg  gaaaagagc  ggaaactaa  ctggttaga  13080
tgaacctgg  tccctgagc  tccctggat  cttcaaata  gccctgaga  gtgaggtct  13140
ctgcttcac  ggggcccga  gactttggc  gggggaggg  gcctagggc  tcttctcat  13200
gaaagctct  ctttataca  acccaagca  acacaccag  ccgtcactt  gggttctgg  13260
ataagttca  aacaattca  gtccatgtg  cccatggct  gtcagagcc  tgggtcaaa  13320
ccactcagc  caggggagg  gatgaggca  tgtcaccct  gacccctct  cctctctcc  13380
ccaccatag  gtgcaataa  gtgtctgtt  ttaccaaac  cttcttgcc  ttctcacct  13440
ctcttgcaa  gagggagag  gaagggtgg  caaggatcc  gcgggaagc  ttggggtga  13500
aagcttgga  tgggatggg  ggacaggac  gctgagggg  gttgtgggt  ctggctggc  13560
gaggagcag  gcggggagt  tgcacaggt  catatctgt  ttttcctat  aattgtcct  13620
ggtattaac  atgcacaca  ttgtagagg  ccctattgg  gtccagcga  tccacatgt  13680
taatttcct  tcatctttg  aaccgtttc  taagggaga  cctttgctg  ctacatttt  13740
ccaggtgaa  ctgcatctg  aattaggat  gtatttggt  gtctcttac  ggaccctgt  13800
ggggaaact  ctgtcccac  tgactacca  gaaaagcta  acttgtcag  ctggcaagg  13860
tggggtgtg  ggaggccca  ctcagggaa  gacaggggt  ggaaggtgc  agtgttgag  13920
ggtctgaca  caaggacca  gactctctt  ggtgctggg  tgggggggg  gtgggctcc  13980
ctggaacag  catattcta  agttctgcc  ctctcttca  gatagctat  cctcttgca  14040
acttcagta  aaggtaaag  cgaactagg  gatctgaca  cacctctgt  ctaacattc  14100
agccccaag  attcattta  taaacaccc  ctgaatact  agcactgtg  agaacggac  14160
gtgctggtg  ctgggaagc  cttcttcct  cctcaccct  taggagcac  gacattgaa  14220
gaaacaaga  gtctggctc  tggaggagg  ctcaccccc  ccccaccca  ctccaggct  14280
gaatgatgc  gcttgcact  agacgcaca  agccaagga  cctgaagga  cctgccatt  14340
tcttctctt  ccatagaaa  tgttgttcc  ggaatagcc  ccagatggc  ggaaaacct  14400
tctcgccag  tcatagtct  cttgccttc  tctctgtca  ttattcctt  gtgggttag  14460
ttatttgtt  aacaaacat  tattacgta  ccaccctgg  caggctcca  gccagctat  14520
gatgaataa  gataaaatc  gcccctgct  tcctgagtt  ggcagaggg  ggggaccgg  14580
cctataact  cacatctcc  catgtatct  tcaaaccag  aaatggcct  gtgctgaaa  14640
tcactcctt  tcaagtatt  agtcttttg  ttgaaggta  tgtttttgg  tgagatgca  14700
gccctcttg  caggagggg  acacagatc  accaagatg  agcataaca  gggctttgg  14760
tccaaggag  tctagagtc  tacttctca  gttcaagtt  aaatgccac  cagcttcct  14820
cttcctggg  ggccttgag  gagtcattt  atcgctctg  gcttaaatg  cctagtctg  14880
aaaacagac  taataaata  attcaatga  ataacacat  ttggtccag  tatctattg  14940
tgtgttcca  gttactcca  gtctgagcg  cttaaaaca  ccattctat  tcgcagttt  15000
ctgagtaag  aattcaggc  ggactcgtc  gagcaactc  tctggtggc  accaaggtc  15060
ctcagtgat  ttcaactag  agcgaacta  tctggaggg  ccaaggcag  tgccctcac  15120
ttcactcaa  tgccgggca  tccagtgag  atggctgga  gactgagtt  agctgggcc  15180
gccggccag  gtgagcacc  acaactgcc  ctccagcat  gctacttgg  cagacttct  15240
actgaaggg  ttagggtcc  cagagagac  atttcaaga  acaggaggt  gaagctgcc  15300
ggtttttaa  gcctggggc  ggaaaatgg  acagtacct  taccatctt  tgtgggtca  15360
agcatctgc  caaataaag  ggagggcac  cagaagccc  ccttgttga  ggggagtgg  15420
gagagtctg  ctgcccatg  aatgggctg  ttctagagt  ttagggatc  ttgtcatca  15480
tcacctgca  atgcatgga  gccttctcc  gaggggatg  cagcttaga  acacagaac  15540
gggacacac  gcaggtcat  tctggtggg  aggtgagtg  ttaagtttg  gccctgggt  15600
gagggagca  tcagaggag  atgagaagg  catgcagga  gacaggtga  gccactgct  15660
ctgcctcag  tttgcccca  ggcaggtgg  atgagtggt  tgaatcatg  gtctgtcgc  15720
aaccatacc  ccttgggga  gccacttta  ccctggaat  tccattttc  gatctgtaa  15780
aggaggacg  caataaaat  tcttcctta  agatggtat  agggaaaaa  gaacttcat  15840
agtaacatc  actggaata  agtatcgac  tctttccat  tggggatac  ataggtgct  15900
attaaatat  tccttcctt  cttcttgcg  tcctgggca  ggccatggg  cctacttca  15960
tctgggggc  ccatcaccc  tgcaatgag  catctccta  agctattca  aaaggacag  16020
ttcagccta  aatccagag  agccaagga  ggaaggcag  aaaggaact  tctccagga  16080
agggagtac  agagtgtgg  ggtctcact  atcctgtac  ttatcatgt  caccccagc  16140
gtcaccacc  gacagctcc  gtcataggg  cttgggcca  ggctaaagt  ttccacaga  16200
cacaaggct  ttgtggggt  ttgtttttg  tttctttgt  gttggttgg  cccaaattc  16260
ttttaatac  tctcccatc  aaagtggag  ctatgctcc  cctcttgaa  ctgggtgag  16320
aaatgcttc  tgtgaccaa  agggtatag  agaagtgat  ctatgtgac  tccaaggct  16380
gattaggaa  ggccgtgcc  cttccacct  gtgttctag  gatactcat  ctagaggca  16440
ccagctgcc  tgtaagaca  ccaaccacc  tgagactgc  atgctaggg  ggcgatatg  16500
ttgcagatg  ttaggttga  agcttcagc  gagcttcca  ccaacagcc  gtgtcaact  16560
ccagccaca  gaacacagc  tactgaacg  ttagcccag  tgagcttca  atgtttgca  16620
cccgctgac  tctgattgt  gctgcataa  agaccctaa  caagaactg  tcaactgag  16680
ccttcctta  ttcctgacc  ataaaataa  aaacaaaat  aaatggctg  tgggtttat  16740
tcactacat  ctaggggta  tttgtttca  aacaatagt  accagaata  gaaccttag  16800
gattatctg  tcaaacctc  ttgtacaac  atgggggaa  cggaggccc  aagaggaaa  16860
gaccagact  cccacaacc  agcaagggg  agatcgggg  caatgcctg  gtttcttga  16920
tcccaatct  gtgcactct  tgccacaca  caagaaact  acagggagg  ctcctcccc  16980
gccaccccc  gcctcatta  ttccatgca  caagcaagc  tgaatcagg  attttgagt  17040
cctgggatt  tgctgagca  tgggaatat  caaaggacc  ggcaagagt  cctggctcg  17100
agaggcagt  acaatctga  ttgggcatc  cccttcctg  cacactcac  ggtgccagg  17160
acgctgctg  attctttaa  tacatcatc  taggtggga  gaaaccttg  gatgggaga  17220
gactatgcc  gtcattcaa  cacaaaccc  tacaaagat  gatccatgc  aggcacagt  17280
ctggctgca  agcataaag  ctcagtggg  atctgctct  tgtccctgg  tctgagctg  17340
ctgggttct  ggtccctcc  ttctgccca  ggctgaccc  agcagggaa  aatccctgg  17400
cttcaggag  acccaagag  aacctgagt  tggcctgtc  ctccagaca  ctgcttccc  17460
tttccccag  atattgctg  aggggactg  gcccatcag  actaattaa  tcctctaat  17520
gaatgaacc  gtttttcct  gaacttagc  caggtggga  caatctcta  ttttctaga  17580
ggagaaatg  taagtgtca  gaggtcttg  cagccggac  ctgggctag  gtgcatgtg  17640
caggcgcgg  ggcgggagt  tgctgtctg  atgcaggct  agttcccag  ccaggagcc  17700
taaacaagg  ggcctctag  gtccactca  ctggtggcc  ccgtatcgt  ctctgtcct  17760
ggcccaaca  cagccctag  tccgtctct  agagttcgc  gctgctgct  aggcctgac  17820
tccctaagc  gggggaagg  gtccatgag  taacactca  gtcccctcc  accctatga  17880
tccaggtcc  tagtgtatg  ggccctgag  cctgcccag  cccgagctt  tgatctctt  17940
tctttaaga  ctgggcctt  aaaggccac  tttgagccc  agatacaac  tcactggga  18000
taccacagc  acccaaccc  gctttcagt  ctgaggcag  gccattcta  tgatcttca  18060
aagacctga  ttactaggg  taggttctc  ccagagccc  tcccccacc  acccccctc  18120
ccccaaaga  ggctctcac  tttgatttg  agcctgcaa  tctctgcag  ctgcttggg  18180
ttgggggag  caggatgaa  tgagctgag  cgcagacag  aggctgcca  cctgctctt  18240
ccttccctt  tcttgttcc  ccatgagcg  ggaggccct  tcaccctct  atgagtctg  18300
taaagcaat  caattttcc  ggctgggag  gagtgaggc  tgctgggaa  ggatgctgg  18360
tccttggcc  ggacctgaa  gagggtcag  ccctggcag  agctagaat  ccaaaaagg  18420
aaagtgtga  caccaatgg  tagaacctt  ccttggcct  gagcccctc  ccacaaaca  18480
gtttcaaag  aggaagatg  agaggagat  ggatggctc  agtcatcct  aagaggctg  18540
gcccataca  agctcccag  ggggaaagg  gaagggtaa  cggctttga  ttcaggctt  18600
cagcttcct  cggacaggg  cagcgtcgg  actcagagg  tgaggacct  attatgcgg  18660
tggaggggg  gcctggaaa  ggtgcaggt  cttgacagc  tccatcggt  cccctttag  18720
atctcccat  gccctctct  cctattctt  caccacacc  tcacccctg  tgagggaaa  18780
ccgctgtgg  tgacacctt  tgtgaactg  ctttcagac  ggtgctctt  cctgacagc  18840
tgaagaagc  agggcacta  ggagaggac  aaagagaaa  ggtgaaaat  agggaaaga  18900
gcttgggga  ctaggaatt  ccaatagtg  ctgctttgt  gtcttgctt  agcctgtca  18960
gtatcaagg  cttggagga  tgaagaagg  agggagtag  cagagtccc  atggcagag  19020
taggctaga  gatgtacct  aggtcctgg  atcaacagg  agcccagaa  cagctgcca  19080
cccatctgc  cacatcaca  cccccagag  tcagggcga  gtctggagc  aggatgttc  19140
agcaccacc  gagggcagc  ccctcacat  catggtagg  tgtgtcaca  tagcctggg  19200
agggggctc  cctatcctt  cccggctct  tgttttgag  gaacaccaa  acctcacac  19260
aagaaatga  ggggacaag  cccatagtg  taactgcag  atatcgact  cctcagaga  19320
gtacacgta  caggtgagc  cagagttct  gaataaacc  tcagcaagg  tgaggcatt  19380
tctggaggc  tcaggactg  ggctgagct  ccctctccc  agctggtca  tgcacagag  19440
tgggagtcc  ggccccatg  acctttacc  agctgcctc  ctcaggctg  gccctctgt  19500
tttgtcagc  cttcctagg  tcctatgcc  gtgtcccaa  tttctgatc  tcctccctt  19560
cctcttggc  tcctttttc  ctggcagct  tctcccttt  cccatctcc  caggtgctc  19620
tcactatcc  caagcaccg  agagtggaa  caccagttg  gcagattta  taggatgag  19680
ggctgtttt  ttcactgat  tatttccag  acccggaac  gcttctggc  tatcgtagg  19740
attcaataa  tgttcattg  gttaataag  caatcaggg  tgggatact  tgggttttg  19800
ccccttgcc  actacactc  ctttgttac  attactgag  tcagtcatc  tgatgaacg  19860
aaagcaggg  agagacccc  agggacttt  ccaggacac  gaccagata  gacttgaaa  19920
ttattcatt  cattaatat  ctgtggttc  ttcttcctc  ctccagttt  tggcctgtc  19980
cgggtcttc  cttcccagt  acacttggg  tatttcttt  cactgcagc  aactcaaag  20040
cagctaaac  ctgaaatac  aacatcagt  tcgaggagc  gggactggg  acaaagggg  20100
tgccagtaa  tgtgtgttt  tgattaact  acctcccct  cgtgtcagt  cagatcatc  20160
aagatcatt  tcattttgg  tttctggcc  cattaataa  gagactttt  cttgtaaaa  20220
tcccttgca  tggcactga  cttttaacc  ttcctgaga  acacatagg  ccttgtctt  20280
tttttctca  ttgagctag  tactgcctg  tctggaact  ggaaggtgc  caggtgtcc  20340
gggcaggtg  gtcattcac  tttcatttc  gcctcaaga  ctctttaca  catccagac  20400
ggcatggag  ctgcctgaa  ctgtaaaaa  gaaaaaaaa  cccaatggg  attaatatg  20460
agatgtaaa  taggttctg  acttaacaa  aacaaatga  tctggaaat  gctcttggg  20520
tagggccag  aaagtcctg  tggtgccta  gttttgggt  tggcagctt  tcaatcact  20580
agcaaacag  ttctcagag  caggcactg  gggagctat  aagatgaaa  agcacaatg  20640
cgcctgcag  agctcaggg  tagggaggg  agaggagac  tatacacag  caaagtcaa  20700
ttgtaatgg  tagaataag  gtagaaaca  gaaggggtc  tgaggcagg  cacgggcat  20760
tcctatgtg  accccagag  aatgacgag  aaaggcttt  actaatgac  tttcagggc  20820
acccaccca  tccacatcc  taaaacatt  cgcgatgaa  acagccaga  ctacggttt  20880
cttccatcc  gcacaagaa  cgcttctct  cccaaggcc  ccccgtcct  cattccatc  20940
cggggactt  ggtggctgg  acagaggcg  agagcatca  gaccatggg  gtcttgggc  21000
acgttgggc  tccgaggcg  aggatgcgg  gcggggtgg  cagaaggcc  caacacggt  21060
cctgggaaa  gagagggca  cctgatcct  gcgacagcg  ctctaccct  tttcttcct  21120
ggccttccg  cagccgcag  gaaacggca  cagtgcgac  agcttggcg  ggagggggc  21180
agggacgaa  caagaagag  cgggcggag  ttagaggtc  ggggtcgag  gcgcttcgg  21240
gtcagcggg  tgcggtggg  ggagctgcg  gcccggggg  ggcgcggag  agggctgag  21300
ggggcggga  gggttgccg  cggaagcgc  caggggcgg  gcgctgggc  gggcactgg  21360
ggcgaggag  tgacgcgct  ggttggggc  cggctccgg  gaggaagac  gcgctcggt  21420
gccagggcc  gcagtgagt  ggatcggcc  cgcgctgcg  cgcgccccg  ccaccccgc  21480
ccgcgaagg  cgcgtctgg  cgaggcggg  ccccggagg  aaaggcgcc  ctggggcgt  21540
gcggccgct  ccagcgccg  agggagacc  tgagcccct  gggccccag  ccaccggcg  21600
cgaggcgcc  cctccccta  gccacctcg  gcccgcccc  tgccgcgcg  gagccaagg  21660
cggcgcccc  cccggagat  ggcagacgc  tagatggcg  ggctcccag  gccgccaga  21720
cgcaggaac  aggcgccgg  gcgttgcgc  gaggctccc  ctccgcgcg  cccgggaag  21780
ctgcaggtg  ccttggccg  tcggccgcc  cccccggta  accttcgcc  gtgcccaga  21840
cccggctcc  cagagcggc  ccgcccccc  ggctcggcg  cgcgcagga  gccccgtct  21900
aggcacccc  gccccagcg  ggcccccgc  gcgctgcgc  cggtccggc  cagctccca  21960
ccgcggacg  aggacccga  gctcgctcc  gcgggcgcg  ttgttttcc  gctgccgcc  22020
cgccctgcg  agcccccgc  cgcccggcc  ccgctctct  ctctgcccc  cctgccttc  22080
tcgcccggc  ctggattta  gaatggggg  aagaggcca  atgccgccg  cgccgcctc  22140
tgttgaccg  aagcagccc  ggcccacgg  gctccggct  ccgtgagag  gtcggcctg  22200
ccccggcag  cgctcggag  acttgttgc  gctgcgctg  cgccgctgc  gggaagccg  22260
ctattccgg  gcttggtgc  gtcttggag  cggagggtg  cccgtgtga  cgcgagcgc  22320
ccggacctt  gcggtgcgc  tggactgtg  gcttcctcg  ctttggtcg  ggtgaaggc  22380
ggggcgtgt  cccggccca  agcgtttgt  tgtcccgtc  tagcggggg  ccgcgtgtg  22440
gcttgcttc  acttccccg  gtcctccct  tctgcgcct  cctctctcc  gagcttcct  22500
ccctaaccc  aaccacctg  gtaccggag  aatccaact  ctcccgctc  gcgtcctag  22560
gggataggc  ggggcaagc  caagccgca  agggggccg  caccgcctc  tgcctcctc  22620
tcgtctcct  cccctcccc  gtctgacgc  gcctcctcg  gaagggtgt  tggagggca  22680
cggccgccc  aagccggag  cccgcagcg  ttcttatga  cagctcggt  tgtgtctcc  22740
cctaccgcg  gcgcaagtc  gggaacaag  ctccgtcca  aacatgtct  aaggaggag  22800
tggccaagg  cgaggcgtc  gagaagatc  tcatcaacg  gggcggcac  cgacatgag  22860
cctaccgca  caccctgcg  accctaccg  gaacccgcc  cgcctggct  gccgacccc  22920
acggcgggg  ccggcccga  accgatggc  gcggtgtgg  tagcagcgg  agcagcggc  22980
gcgggggct  cgagttctt  ttcgacagg  acccgggcg  cttcgccta  gtgctcaac  23040
actaccgca  cggcaagct  cactgcccc  cggacgtgt  cgggccgct  ttcgaagag  23100
agctcacct  ctggggcat  gacgagacc  acgtggaac  ctgctgctg  atgacctac  23160
ggcagcacc  cgacgccga  gaggcgctc  acatcttcg  gagcccgga  ggaggcggc  23220
gcggcgcgg  gcccagcga  gaggccggc  acgatgagc  ggagctggc  ctgcagcga  23280
tgggccccc  cgagggagg  gcgggccat  gcgccgggt  tgggggctg  cgcggctgg  23340
agccccgca  gtgggcgct  ttcgaggat  cctactcct  ccgggccgc  agggtgagt  23400
gcaggagcc  gtgtctccc  atcttgggt  tgcaagggg  ccgtggtgg  tggtgggta  23460
gggccggga  gagcaggga  cgagcctga  ttaccttac  accgcagat  gttcccgcc  23520
tcctctcaa  ccccctccg  ggctcgcag  ggaattaca  actcccacc  tctcccctg  23580
acgctccat  aggagattg  acacacttg  cttactact  ggacccagt  ccagctgcc  23640
gctttgccg  atcccctcc  gtgagtggg  tgcccagct  agctcctcc  cccccttct  23700
tggtctgca  aggctgccc  atcttcagc  gccctccac  ccacacagg  ctacggtcc  23760
ggaagagct  gaatttggt  ttctgatgg  ggcaggcag  gttgagagg  aggaaacta  23820
ggtgggttt  gttagatgc  tccatgccg  gccacctca  ttacatcct  ccagcagct  23880
agtgtgctc  caactatgc  cttcagaga  gaggatata  gcttcagca  cttaagctc  23940
gaagaggca  agctgagac  acaatccgg  ctcctttcc  ggtttaaga  aggcattct  24000
tctgccagg  aggatacca  gcccctgag  cttcctgca  acctgggat  tcctggcct  24060
agctggggt  agaggagaa  taaacacga  gggcctagc  ttctaggct  tgcaggctc  24120
cacggccag  ggccagcca  aggcttcct  gtgatgata  cagattttt  ttgccgctt  24180
ttttctttc  gctgcagca  aaactgtct  tccagaaag  cctggttca  gttactgct  24240
gaaatgggt  tatgaggga  gggggaagc  caggttgat  taggcaaga  ctaccgcct  24300
ctccccaag  aaatccagt  tccctaact  ctttaggtg  aaggggaga  cgggggagg  24360
gcttccccc  ttatgcttc  acagctaaa  aaaaaaaaa  aaaaaaaaa  aaatccctg  24420
aggatggct  tagattctt  aaagaaaga  aactctggg  gctggtgtc  gatctcatg  24480
tcagcagcc  aaagcctgg  tggagtctg  ctgggagac  ggaaagagc  atgtaactt  24540
ttgggtctg  ggactgctg  ttgctgtgg  acctggttg  ttcctccag  atcccaaat  24600
gtcatgtta  tgagtctca  agcaccctc  ctttcccag  acccctgtg  tggactcct  24660
cctagtcat  gaagaaggc  gggtaggga  ttggggaac  ggcctgcag  gaaaagcca  24720
gctggcata  atgccaggc  agggcagat  catcttctg  ctggaagag  agggaggag  24780
agaggtctc  ggggccatg  cataccggg  tggggctgc  ggcagccac  agaaggcag  24840
gatctttct  aggactgac  acaaagcta  aggcaactg  ctgggtttc  ttccttgca  24900
ccctgagac  ggctaagaa  gtgagggca  agtgatgcc  ctggcctgg  tctgctgtg  24960
gttctacag  cttctcatg  aggtcacta  ccttgctag  gttagcact  ggctgtctg  25020
attagggga  agagggcag  cacacatca  tcagactct  tcaaagttg  gggtcgggg  25080
ggagagata  agatagaga  ggggaaagg  gacaaacca  ggaagcagg  atgagatga  25140
gtggttagg  gagctaggc  ctatttctg  gcattctgg  acttctagg  gcttttcac  25200
tgctcttct  cccctctgg  attccaggt  gcaccccac  tatcattga  tttattttc  25260
tcctaactc  ctgctgaat  gccaagcca  ggggcctct  tgagtaagc  cagagcctg  25320
cctgcccct  gaagtcttc  caggaaccc  gggtgcttt  cccctttga  atggaatca  25380
atcagccca  gcattccag  tgaggtctt  aagtttatg  tggagcaag  ttaattctt  25440
catttaaac  ttgagaaaa  caggattca  agacattaa  tttcttgcc  aagacattt  25500
actaatagc  gaggcagga  accacccct  gtttccagc  ttctggttg  tcatcctga  25560
gtgaatatc  ggatggagc  ctggccaac  catgcacta  aagaggact  gcctcctgc  25620
caggagccc  ggcaaaggc  accctcacc  gctcccggg  cacacaagt  ggaatacat  25680
atttttaca  attaatgaa  aactgctca  tattgagca  cccagacag  tacattgct  25740
tatatactt  acattaatc  ctaatcctc  caataaact  aaaacccgg  gattatccc  25800
gtttaatag  ttgaggctg  gagaaggta  acaacttgc  tgagatcac  cagccagat  25860
gtggccagg  tttgaatca  agccagagt  cctgactcc  aagcccttg  tcttgtgat  25920
acaacacct  ctttccact  aactaggct  tttttgagg  agagagctt  tttcttact  25980
tagcctgag  aatgtcctt  tgaggttct  tacctcctg  ggatgacat  agaaaaccc  26040
ggggcagat  gagacgtca  aaggaagac  tactgtatt  cccctccag  cctgagggt  26100
ctatgccat  cggggagtt  tggggctgc  ctttccccc  tccatttgc  cctggcttg  26160
cacactgtc  catccttcc  agccctgtt  cccccggta  atgtgctac  ttccctcgc  26220
cacagctac  tcctccctg  aagggcccg  agcactgtg  ggtggtggg  gaagaggga  26280
agaggagca  tgctctgcc  tgaggcgtc  tttcgcaca  agcaacctg  tcatttgag  26340
agtgcgtta  gacaggagc  aaacgatac  aatggaaag  gaactgagc  gattatgag  26400
gcctgttgc  tagctacag  cctggccca  ggagctgtt  cgctcaggc  ggctcctgg  26460
ctgggatgc  cacccctgc  ccactgtgc  gggcccatg  gcagctgct  ctgtggttc  26520
gtttctgtg  cctgagctg  gaacaggta  gaggggcag  gcagagtga  ggctcaccg  26580
ggagacttc  cagcctcag  gggcccagt  gaggtttgg  agcatccga  actttagaa  26640
cctgcacct  cttttctga  agcagacaa  aggcctgga  aatggggcc  ggatgccct  26700
cccctaccc  agtctccaa  gtctccagg  cagggctgg  tttagctca  ctatcagcc  26760
tattaagga  tacagttcc  ctcctttgg  taaatcagc  catttttcc  gtgatgttt  26820
ccttttgag  agaggaggg  acccacagg  actccctgc  ccaggaagg  agctccagc  26880
gggtcttcc  ctttgttaa  tgtcagtta  tatgtggga  gcttggcct  tgctttctg  26940
tactactca  ctggcctag  tgaggcaga  attgttaac  tctgtgtat  agtatacag  27000
taaggaaac  ggcctggtg  ggctttctc  aggtcgcac  acttgtggt  gaactagga  27060
ccaaaccta  gtctcatca  tctaagtct  tgctcctcc  atggcctct  gctcctgcc  27120
agagaggat  tctggtttc  agagggtgg  ccctcactg  agagcttct  cctccactc  27180
gctcttatc  gttccttta  ttctcactc  ccagaattg  tcaaggata  cctctcttc  27240
cactgtggg  tttccatag  aaaaatgaa  ggaggcgtg  ctgggagaa  agactaagg  27300
aagctccct  gcccaggca  agcatgaaa  caaggcctt  taggaaagg  gcagagctg  27360
attcctgcc  gcccgcttc  gaagttccc  ggcttctct  gtccgggca  tgcctgggg  27420
acaggtcag  gatcacgac  ggctttaaa  tgagggcca  gactcactg  tgctgtgcc  27480
tctgagcta  ggtgaacca  gaacctgag  ccaggaggg  agtaccctg  ctttctgag  27540
tccccagga  ggcagtgcc  agcctgccc  gggcagccc  tccacctcc  tcctgagga  27600
caggcaggg  ccaggctga  ggctgcagg  ctccctgca  gccctgccc  cagggcatc  27660
tcccagttt  ctcttgggt  tgttttctt  tcttgttct  aacagatca  catttgtct  27720
tgaacatct  gtctctgaa  gctgaggtg  ttctggttg  cacattagg  gtggggtgt  27780
gagtaggga  ggggagaaa  taaacgagc  attttggag  ctcggggga  gagcaggca  27840
gcaggagca  agccaggca  cttggcctt  agggtagga  accctgggc  cttcacccc  27900
acccatggg  agtgtcagc  tgggatgct  ggcaccaga  ctctgtgca  ccctcattc  27960
ctgtgcgta  ctgacttgc  atgacctct  gccctgctc  ctgctggaa  tttcttcag  28020
ctaaggggt  gtcacctgg  ccctagcag  ggtccttat  tggaagtgg  cctggctcg  28080
tctggaggg  agcagaggt  ctagggccc  agcacctag  ggtattact  ggcatatac  28140
cttgtcact  tgtcccagt  agtggagct  atgacctct  cttctgaca  gctcatcag  28200
accaggaga  agagcaggg  gtcaccttg  ccccagtca  tcagaaaac  cttactgcg  28260
acttaccat  cacatgtgg  gttctagaa  tccaaagat  agtcagagg  ggccatgct  28320
ctgacaaaa  ccaagtcgg  tagagtaag  ggcagtcaa  ggaaattag  tgacaagaa  28380
tggcaacag  aatacaaga  ggatcatga  aggtgccac  ggagtcgta  gaaaataaa  28440
ttcaatagg  agtgagagg  ggaatcaat  aatcccacc  ctacgtggg  tgaggtgta  28500
gaggtgttc  gagaggctt  cacaaggaa  tagaagttg  attgggtgg  ccttgtagg  28560
tactgactt  gtgccttaa  taatttttt  aaagagtca  attataaat  catacataa  28620
taaataaaa  ttccatgtg  gtagagcta  accatatgc  gcgttaggg  aagggggaa  28680
tttctggtc  ggtgaccag  tcaagcaga  cttggacag  gtggggcct  ggtgggcaa  28740
aaccaggaa  tccatttga  tgaatagcg  gttcttgga  agtgatccg  gctagactg  28800
attccttct  gggtaggga  tcatccgtt  tgggcaacc  agaggccct  agaggcccc  28860
agtgctggc  cgtcggagg  tgagcatag  tagaggtgg  ttctggaca  tgggaccag  28920
aggtcctgg  tcagcatgg  gtgggggca  ggccaggtc  tgttcctag  ggcacccat  28980
gaggggaga  gaggggatg  ttctctgct  ggacctagg  cttagtgcg  gccctcaac  29040
aggagccag  gatagctca  agatgcttt  tttggcaga  cttctcatt  cctgcctct  29100
acccccggg  ctgccccac  gtcttccag  actgcctgg  cacaaggat  ttgcttccc  29160
ggaaggctc  gtccctcag  ccctcaccc  atccccaca  atcttactc  gccagtgtc  29220
ttggctgtg  tctcaattt  cccttctcc  acacttcat  cttaatata  gtttttggg  29280
ctgagtctc  ttatgttta  ctgtccatc  gtctccctg  cccttcttc  tgggctctc  29340
tcccctgcc  ccgctgatt  tatgcagtt  ccaatgatt  gtgtctgtc  cctctcccc  29400
cgacccagc  tgtgccaga  tcctggaat  ctctaggct  tgtgctgag  tttacaagt  29460
tcatttctt  gcatcctca  aacaactgt  ccaggtaga  actaccctc  tcccctcaa  29520
catagcaag  agattgtag  ctcaggacc  ttgcactac  catcccttc  gcctcgaac  29580
ctccggttc  tcgtatgac  cactccttc  ctcttcagg  ctgttcagg  gtcaccttg  29640
cattaaggc  ttacctgac  tctctattg  aaacaactc  cctatcctc  cacccgtta  29700
ctccttttt  tctttattt  ttttcataa  ccttagacc  cctgacata  tgtgtattt  29760
gcttgttta  ttgttaaag  cggcctcca  tagaatgta  ggtcccggg  caagggtgg  29820
tgtctggta  tttcccaaa  acggtgtct  gtacttggt  ggcgctccc  ttttcactt  29880
ataaatgaa  accttaagg  ttggagagg  taaggaact  atgcaggtc  catatgcag  29940
cagtagcag  gcccaactt  aacccagaa  tgtgtggct  tacatttct  gggacagtc  30000
aacggtggg  ttggtggag  aggatggta  tagggctga  caactgggc  tttggagag  30060
ggtgagttt  caacaggac  caggagccc  gggggcgca  ggagttggg  ggagaggcg  30120
tctcctgct  agaggatgg  agcctgctg  ccagggtgc  gagaccctc  tgcatcctc  30180
cagcaggag  ggagctgcc  ctggtggag  cagttcacc  gcagttttc  acttgggaa  30240
ttttgcctt  cagcagaat  catgccctt  gtggtggaa  gaactagca  cttcagcca  30300
gaaaatcag  acaagcaag  actcctccc  gggcctcag  ttcttcatc  gtaaaacag  30360
agaaatgga  ttgaactgg  taactttct  agtctccgt  tttcacttc  aaaaagcaa  30420
gattctgtg  tattttggc  ccagattcg  ctcaccttc  aaagctgca  gcagaggac  30480
ctaaccctc  tcaactctt  tctccattt  atggagcac  tattgggtg  caggcattt  30540
ccatgtaga  gctcattta  tcctaccgt  acactgtga  gggggtact  gtactgtcc  30600
cattttata  agaggaaac  ggtgcagaa  ttaccattc  tttacctgg  tgagtggca  30660
ggccaggat  aggaatccc  gaagtctaa  cccgggccc  aggcttcta  tgtagggtt  30720
cttagctgt  ctctgccct  agtctgtca  cacaggggc  catgagagg  aggctcgga  30780
ctccactgc  agctctgta  gatggcagg  tggtccagt  gggaatgaa  agaaggctc  30840
aggctgagg  tttggcctc  aagcagggt  gtgttgctg  aaccacctc  tcttccctt  30900
gcccccttt  gtgctagga  gccctagtc  agggagctg  gtatccctg  ccacaggga  30960
acacagtgg  tacacagtg  ggacaggtg  aaaggcctg  tgaaaagca  catttgcaa  31020
cagggtcaa  cacttatga  ataattcag  ttggggagc  acatagggc  gaaaggaat  31080
atttgggcc  tgaagggga  cctgtaacc  caggaccca  ctggagcaa  gtgccacag  31140
tcaggccgc  tctctgtct  cttggggag  gagggcttc  tggggcctg  tgagtgcct  31200
ctgccccag  cctggagag  ccacagtgg  gattgaggc  ccaccaagg  ttcaacaaa  31260
gaggagggg  ttataccta  ctgctcggt  agaggggcc  attggaaag  gctttgagc  31320
gagagtcag  agacttggc  tcagtgtga  cctgagcaa  tcatctgcc  tctcttgtg  31380
ctctatttc  cttaaaaaa  gggcacaca  gaccactct  tagctcccc  cctcttctc  31440
gggtggagg  gaggggtag  agttaatag  agatggaac  gttctgtgt  ttgaaaaaa  31500
gcaaaggtg  atggacaga  aggaatcca  ggggttgtt  cctaatcca  gatgtggct  31560
gtgcccacg  ggcctgaag  actctcttg  ctgctgcag  atgagccca  ggtggtggc  31620
gttgaggag  gtagcaagg  aggctccct  gccctgcta  gagaggatg  ccggggcca  31680
gccgccctc  ctccctccc  ccctctgct  accctcttg  cagctcttc  tgaactt  31737



<210> 9821
<211> 606
<212> PRT
<213> Homo sapiens
<308> CAC19684
<400> 9821

Met Ile Ser Ser Val Cys Val Ser Ser Tyr Arg Gly Arg Lys Ser Gly 
  1               5                  10                  15
Asn Lys Pro Pro Ser Lys Thr Cys Leu Lys Glu Glu Met Ala Lys Gly 
             20                  25                  30
Glu Ala Ser Glu Lys Ile Ile Ile Asn Val Gly Gly Thr Arg His Glu 
         35                  40                  45
Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr Arg Leu Ala Trp 
     50                  55                  60
Leu Ala Asp Pro Asp Gly Gly Gly Arg Pro Glu Thr Asp Gly Gly Gly 
 65                  70                  75                  80
Val Gly Ser Ser Gly Ser Ser Gly Gly Gly Gly Cys Glu Phe Phe Phe 
                 85                  90                  95
Asp Arg His Pro Gly Val Phe Ala Tyr Val Leu Asn Tyr Tyr Arg Thr 
             100                105                110
Gly Lys Leu His Cys Pro Ala Asp Val Cys Gly Pro Leu Phe Glu Glu 
         115                120                125
Glu Leu Thr Phe Trp Gly Ile Asp Glu Thr Asp Val Glu Pro Cys Cys 
     130                135                140
Trp Met Thr Tyr Arg Gln His Arg Asp Ala Glu Glu Ala Leu Asp Ile 
 145                150                155                160
Phe Glu Ser Pro Asp Gly Gly Gly Ser Gly Ala Gly Pro Ser Asp Glu 
                 165                170                175
Ala Gly Asp Asp Glu Arg Glu Leu Ala Leu Gln Arg Leu Gly Pro His 
             180                185                190
Glu Gly Gly Ala Gly His Gly Ala Gly Ser Gly Gly Cys Arg Gly Trp 
         195                200                205
Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Ala 
     210                215                220
Ala Arg Val Val Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser Ile 
 225                230                235                240
Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile Asp Arg Asn 
                 245                250                255
Val Thr Glu Ile Leu Arg Val Gly Asn Ile Thr Ser Val His Phe Arg 
             260                265                270
Arg Glu Val Glu Thr Glu Pro Ile Leu Thr Tyr Ile Glu Gly Val Cys 
         275                280                285
Val Leu Trp Phe Thr Leu Glu Phe Leu Val Arg Ile Val Cys Cys Pro 
     290                295                300
Asp Thr Leu Asp Phe Val Lys Asn Leu Leu Asn Ile Ile Asp Phe Val 
 305                310                315                320
Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser Ser 
                 325                330                335
Lys Ala Ala Arg Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe Val 
             340                345                350
Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu Arg 
         355                360                365
Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu Leu 
     370                375                380
Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile Tyr 
 385                390                395                400
Tyr Ala Glu Arg Ile Gly Ala Arg Pro Ser Asp Pro Arg Gly Asn Asp 
                 405                410                415
His Thr Asp Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val Val 
             420                425                430
Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Lys Thr Trp Ser 
         435                440                445
Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr Ile 
     450                455                460
Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr Ser 
 465                470                475                480
Leu Ala Met Ala Lys Gln Lys Leu Pro Lys Lys Arg Lys Lys His Val 
                 485                490                495
Pro Arg Pro Ala Gln Leu Glu Ser Pro Met Tyr Cys Lys Ser Glu Glu 
             500                505                510
Thr Ser Pro Arg Asp Ser Thr Cys Ser Asp Thr Ser Pro Pro Ala Arg 
         515                520                525
Glu Glu Gly Met Ile Glu Arg Lys Arg Ala Asp Ser Lys Gln Asn Gly 
     530                535                540
Asp Ala Asn Ala Val Leu Ser Asp Glu Glu Gly Ala Gly Leu Thr Gln 
 545                550                555                560
Pro Leu Ala Ser Ser Pro Thr Pro Glu Glu Arg Arg Ala Leu Arg Arg 
                 565                570                575
Ser Thr Thr Arg Asp Arg Asn Lys Lys Ala Ala Ala Cys Phe Leu Leu 
             580                585                590
Ser Thr Gly Asp Tyr Ala Cys Ala Asp Gly Ser Val Arg Lys 
         595                600                605



<210> 9822
<211> 785
<212> DNA
<213> Rattus norvegicus
<308> X62875
<400> 9822

gccccgatg  ctgacctgg  ggcagcagt  tggtcagtg  aggggaagc  taggtccca  60
catgtatgt  ccccatcaa  cgtcaccgg  tgggtttct  agtccctcc  gccccaccc  120
actgagaat  ctgcaccag  ttggctgag  cccttggct  gacaacagg  agtaggatg  180
tgttggctc  acccacttt  ctgctcttc  ctgggacaa  acagatggg  gctaccacc  240
atctcgagt  aggtcctga  cacttccac  taaggcaga  ggggctcca  caggcgcct  300
ccccactac  ctcttcctc  agcagggca  caaggagct  gccttgccc  cctctcctt  360
tgctcctcc  tgcccccaa  gttctggtt  cactttttc  tctgttcac  aactacctc  420
ggacagttg  gttgtgttt  ttgttcaaa  gttcattct  agacaccca  cattgctgc  480
accagcgcc  gatgtccat  ctcccgatt  tgcctgtac  ccccacaca  tacactcta  540
gggaagggg  ggctggtgt  cagcagcag  ctggttacc  agtacccca  gctagggaa  600
atggccccg  cccgtggat  ctgcagcag  gtgaggagg  ggggcccac  tggatggga  660
aagggtata  gaccacctc  ccttgttgt  ggggagggg  ggccagtat  tgtcccagc  720
tggggctcc  cctctggtt  cctatttgc  gttacttga  taaaaaaaa  tagcctttt  780
tggac  785



<210> 9823
<211> 785
<212> DNA
<213> Rattus norvegicus
<308> X62875
<400> 9823

gccccgatg  ctgacctgg  ggcagcagt  tggtcagtg  aggggaagc  taggtccca  60
catgtatgt  ccccatcaa  cgtcaccgg  tgggtttct  agtccctcc  gccccaccc  120
actgagaat  ctgcaccag  ttggctgag  cccttggct  gacaacagg  agtaggatg  180
tgttggctc  acccacttt  ctgctcttc  ctgggacaa  acagatggg  gctaccacc  240
atctcgagt  aggtcctga  cacttccac  taaggcaga  ggggctcca  caggcgcct  300
ccccactac  ctcttcctc  agcagggca  caaggagct  gccttgccc  cctctcctt  360
tgctcctcc  tgcccccaa  gttctggtt  cactttttc  tctgttcac  aactacctc  420
ggacagttg  gttgtgttt  ttgttcaaa  gttcattct  agacaccca  cattgctgc  480
accagcgcc  gatgtccat  ctcccgatt  tgcctgtac  ccccacaca  tacactcta  540
gggaagggg  ggctggtgt  cagcagcag  ctggttacc  agtacccca  gctagggaa  600
atggccccg  cccgtggat  ctgcagcag  gtgaggagg  ggggcccac  tggatggga  660
aagggtata  gaccacctc  ccttgttgt  ggggagggg  ggccagtat  tgtcccagc  720
tggggctcc  cctctggtt  cctatttgc  gttacttga  taaaaaaaa  tagcctttt  780
tggac  785



<210> 9824
<211> 466
<212> DNA
<213> Rattus norvegicus
<308> X62950
<400> 9824

aggaaagac  gaatcctac  agaggccag  aagaatgtt  cagacatgg  tggaaggcc  60
tcactcccg  ctgacttca  tacgcctga  ggtagggag  gctccatgt  tgcccccag  120
ctccaaggg  gggtctcct  gggcctgga  aatgcccca  caatctggc  aagataagg  180
aagggtatg  agagaaagt  acagaaatt  gaagggtta  gctaagttg  tgagagtta  240
tataagtta  agagaaagt  aggttaaac  aagagaaag  gaaaagaag  taaaaagag  300
aggaagcta  ggaagaaaa  agactaaaa  aagaggaag  tagagagct  aagagagat  360
aaagacaag  gaggaacat  tactggcca  agtagttag  gaacctagg  agacagtac  420
tggcaacag  agagaattc  tggctaaag  tcagtgtgc  taatgc  466



<210> 9825
<211> 415
<212> PRT
<213> Rattus norvegicus
<308> AAA40872
<400> 9825

Met Leu Leu Leu Leu Ala Leu Val Ser Val Ala Leu Ala His Ala Ser 
  1               5                  10                  15
Glu Glu His Phe Asp Gly Asn Arg Val Tyr Arg Val Ser Val His Gly 
             20                  25                  30
Glu Asp His Val Asn Leu Ile Gln Glu Leu Ala Asn Thr Lys Glu Ile 
         35                  40                  45
Asp Phe Trp Lys Pro Asp Ser Ala Thr Gln Val Lys Pro Leu Thr Thr 
     50                  55                  60
Val Asp Phe His Val Lys Ala Glu Asp Val Ala Asp Val Glu Asn Phe 
 65                  70                  75                  80
Leu Glu Glu Asn Glu Val His Tyr Glu Val Leu Ile Ser Asn Val Arg 
                 85                  90                  95
Asn Ala Leu Glu Ser Gln Phe Asp Ser His Thr Arg Ala Ser Gly His 
             100                105                110
Ser Tyr Thr Lys Tyr Asn Lys Trp Glu Thr Ile Glu Ala Trp Ile Gln 
         115                120                125
Gln Val Ala Thr Asp Asn Pro Asp Leu Val Thr Gln Ser Val Ile Gly 
     130                135                140
Thr Thr Phe Glu Gly Arg Asn Met Tyr Val Leu Lys Ile Gly Lys Thr 
 145                150                155                160
Arg Pro Asn Lys Pro Ala Ile Phe Ile Asp Cys Gly Phe His Ala Arg 
                 165                170                175
Glu Trp Ile Ser Pro Ala Phe Cys Gln Trp Phe Val Arg Glu Ala Val 
             180                185                190
Arg Thr Tyr Asn Gln Glu Ile His Met Lys Gln Leu Leu Asp Glu Leu 
         195                200                205
Asp Phe Tyr Val Leu Pro Val Val Asn Ile Asp Gly Tyr Val Tyr Thr 
     210                215                220
Trp Thr Lys Asp Arg Met Trp Arg Lys Thr Arg Ser Thr Met Ala Gly 
 225                230                235                240
Ser Ser Cys Leu Gly Val Arg Pro Asn Arg Asn Phe Asn Ala Gly Trp 
                 245                250                255
Cys Glu Val Gly Ala Ser Arg Ser Pro Cys Ser Glu Thr Tyr Cys Gly 
             260                265                270
Pro Ala Pro Glu Ser Glu Lys Glu Thr Lys Ala Leu Ala Asp Phe Ile 
         275                280                285
Arg Asn Asn Leu Ser Thr Ile Lys Ala Tyr Leu Thr Ile His Ser Tyr 
     290                295                300
Ser Gln Met Met Leu Tyr Pro Tyr Ser Tyr Asp Tyr Lys Leu Pro Glu 
 305                310                315                320
Asn Tyr Glu Glu Leu Asn Ala Leu Val Lys Gly Ala Ala Lys Glu Leu 
                 325                330                335
Ala Thr Leu His Gly Thr Lys Tyr Thr Tyr Gly Pro Gly Ala Thr Thr 
             340                345                350
Ile Tyr Pro Ala Ala Gly Gly Ser Asp Asp Trp Ser Tyr Asp Gln Gly 
         355                360                365
Ile Lys Tyr Ser Phe Thr Phe Glu Leu Arg Asp Thr Gly Phe Phe Gly 
     370                375                380
Phe Leu Leu Pro Glu Ser Gln Ile Arg Gln Thr Cys Glu Glu Thr Met 
 385                390                395                400
Leu Ala Val Lys Tyr Ile Ala Asn Tyr Val Arg Glu His Leu Tyr 
                 405                410                415



<210> 9826
<211> 1796
<212> DNA
<213> Rattus norvegicus
<308> X62952
<400> 9826

gttcacagc  actgcgccc  cgctctctt  ttgcagatc  tgcagccgc  gcaagccag  60
ccacctcgt  cttcgaagc  atgtccacc  ggtccgtgt  ctcgtcctc  taccgcagg  120
tgttcggtg  ctccggcac  tcgagccgg  ccagctcca  ccggagcta  gtgaccaca  180
ccacccgca  ctacagcct  ggcagcgcg  tgcgcccca  cactagccg  agcctctat  240
cctcgtccc  gggtggcgc  tatgtgacc  ggtcctccg  cgtgcgcct  cggagcagc  300
tgcccggcg  gcggctgct  caggactcc  tggacttct  gctggccga  gccatcaac  360
ccgagttca  gaacacccg  accaacgag  aggtggaat  gcaggagct  aatgaccgc  420
tcgccaact  catcgacaa  gtgcgcttc  tcgagcagc  gaacaaaat  ctgctggcc  480
agctcgagc  gcttaaggg  cagggcaag  cgcgcctgg  cgacctcta  gaggaggag  540
tgagggagt  gcgccggca  gtggatcag  tcaccaatg  caaggcccg  gtcgaggtg  600
agagggaca  cctggccga  gacatcatg  ggctgcgag  aaaattgca  gaggagatg  660
tccagaggg  ggaagccga  agcaccctg  agtcattca  acaggatgt  gacaatgct  720
ctctggcac  tcttgacct  gaacgtaaa  tggaatcct  gcaggaaga  attgccttt  780
tgaagaagc  gcacgatga  gagatccag  agctgcagg  ccagattca  gaacagcat  840
tccagatcg  tgtggacgt  tccaagcct  acctcaccg  tgccctgcg  gatgtccgc  900
agcagtatg  aagtgtggc  gccaagaac  tccaggagg  cgaggaatg  tacaagtcc  960
agtttgctg  cctctctga  gctgccaac  ggaacaacg  tgccctgcg  caggcaaag  1020
aggagtcaa  cgaataccg  agacaggtg  agtcactca  ctgcgaagt  gatgccctt  1080
aaggcacta  tgagtccct  gagcgccag  tgcgtgaaa  ggaagagaa  tttgccctt  1140
aagctgcta  ctaccagga  actattggc  gcctgcagg  tgagatcca  aacatgaag  1200
aagagatgg  tcgccacct  cgtgaatac  aggacctgc  caatgtaaa  atggctctt  1260
acattgaga  cgccaccta  aggaagctg  tggaagggg  ggagagcag  atttctctg  1320
ctcttccaa  cttttcttc  ctgaacctg  gagaaacta  cctggagtc  cttcctctg  1380
ttgacaccc  ctccaaaag  acactcctg  ttaagacgg  tgaaaccag  gacggacag  1440
tgatcaatg  gacttctca  caccacgat  accttgaat  aaaactgca  aggctcagt  1500
caacggcgc  gtaccagca  gaaggaaaa  aaaatcgta  cttagaaaa  agagctttc  1560
agtgccttt  ctgcagttt  caggagcgc  agatagatc  gggatagaa  cgagctcag  1620
acataacaa  tgacacccc  aaaaggcgt  gaaaaggtt  acaaaataa  ctagtttta  1680
gaagaaatc  tgtgctaga  tacttttta  agtattttt  aataccatt  aaactgctt  1740
ctttttcca  aaaatatct  accaacttg  tactgcttc  ataaaactt  agaaat  1796



<210> 9827
<211> 465
<212> PRT
<213> Rattus norvegicus
<308> P31000
<400> 9827

Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly Gly 
  1               5                  10                  15
Ser Gly Thr Ser Ser Arg Pro Ser Ser Asn Arg Ser Tyr Val Thr Thr 
             20                  25                  30
Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr Ser 
         35                  40                  45
Arg Ser Leu Tyr Ser Ser Ser Pro Gly Gly Ala Tyr Val Thr Arg Ser 
     50                  55                  60
Ser Ala Val Arg Leu Arg Ser Ser Met Pro Gly Val Arg Leu Leu Gln 
 65                  70                  75                  80
Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe Lys 
                 85                  90                  95
Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp Arg 
             100                105                110
Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys 
         115                120                125
Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser Arg 
     130                135                140
Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln Val 
 145                150                155                160
Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp Asn 
                 165                170                175
Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu Met 
             180                185                190
Leu Gln Arg Glu Glu Ala Glu Ser Thr Leu Gln Ser Phe Arg Gln Asp 
         195                200                205
Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val Glu 
     210                215                220
Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Asp Glu Glu 
 225                230                235                240
Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile Asp 
                 245                250                255
Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val Arg 
             260                265                270
Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu Glu 
         275                280                285
Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg Asn 
     290                295                300
Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Asn Glu Tyr Arg Arg 
 305                310                315                320
Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr Asn 
                 325                330                335
Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala Leu 
             340                345                350
Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu Ile 
         355                360                365
Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln Asp 
     370                375                380
Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg 
 385                390                395                400
Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro Asn 
                 405                410                415
Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Glu Ser Leu Pro Leu 
             420                425                430
Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu Thr 
         435                440                445
Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp Leu 
     450                455                460
Glu 
 465



<210> 9828
<211> 973
<212> DNA
<213> Homo sapiens
<308> BF344933
<400> 9828

gtgaatacc  agacctgct  aatgttaag  tggcccttg  cattgagat  gccacctac  60
ggaagctgc  ggaaggcga  gagagcagg  atttctctg  ctcttccaa  ctttcccac  120
cgtccgagc  gacaatgtg  gctccaagc  gatgcagca  atccgcatg  cccttcgcg  180
gaaggctgt  gtgctgatg  gcaagaaca  catgatgcg  aaggccatc  gagggcacc  240
ggaaaacaa  ccagctctg  agaaactgc  gcctcatat  cgggggaat  tgggcttgt  300
ttcaccaag  aggacctca  tgagatcag  gacatgttg  tggccataa  gtgccagct  360
ctgcccgtg  tggtgccat  gccccatgt  aagtcactg  gccagcacc  gaacactgg  420
ctcgggccc  agaagacct  ctttttcca  gctttaggt  tcaccacta  aatctccag  480
gcaccattg  aaatcctga  tgatgtgca  ctgatcaag  ctggagaca  agtgggagc  540
agcgaagcc  cgctgctga  atgctcaaa  ctccccctt  tcctttggg  ttggtcatc  600
agcaggtgt  cgaccaatg  cagaatcta  aaccctgga  agtgcttga  attcacaga  660
gagacgtct  catactcga  ttcctggaa  ggtgtccgc  actggtagc  agtgtctga  720
cagaagaat  gctacacca  ctgttggct  aggacccca  catatcatc  aagggtaca  780
cagagtcat  agcactgcc  gggggcccg  ataaccact  cccacctgg  aaaagggca  840
gggctccgg  tgaaccaca  ggcttgggg  ctgaccggt  gcgagaaca  aacggcact  900
cggacggtg  cccccaaca  gtgaacacg  aaacggagg  cggacagaa  agcagggcc  960
gtaccgaaa  aaa  973



<210> 9829
<211> 317
<212> PRT
<213> Homo sapiens
<308> P05388
<400> 9829

Met Pro Arg Glu Asp Arg Ala Thr Trp Lys Ser Asn Tyr Phe Leu Lys 
  1               5                  10                  15
Ile Ile Gln Leu Leu Asp Asp Tyr Pro Lys Cys Phe Ile Val Gly Ala 
             20                  25                  30
Asp Asn Val Gly Ser Lys Gln Met Gln Gln Ile Arg Met Ser Leu Arg 
         35                  40                  45
Gly Lys Ala Val Val Leu Met Gly Lys Asn Thr Met Met Arg Lys Ala 
     50                  55                  60
Ile Arg Gly His Leu Glu Asn Asn Pro Ala Leu Glu Lys Leu Leu Pro 
 65                  70                  75                  80
His Ile Arg Gly Asn Val Gly Phe Val Phe Thr Lys Glu Asp Leu Thr 
                 85                  90                  95
Glu Ile Arg Asp Met Leu Leu Ala Asn Lys Val Pro Ala Ala Ala Arg 
             100                105                110
Ala Gly Ala Ile Ala Pro Cys Glu Val Thr Val Pro Ala Gln Asn Thr 
         115                120                125
Gly Leu Gly Pro Glu Lys Thr Ser Phe Phe Gln Ala Leu Gly Ile Thr 
     130                135                140
Thr Lys Ile Ser Arg Gly Thr Ile Glu Ile Leu Ser Asp Val Gln Leu 
 145                150                155                160
Ile Lys Thr Gly Asp Lys Val Gly Ala Ser Glu Ala Thr Leu Leu Asn 
                 165                170                175
Met Leu Asn Ile Ser Pro Phe Ser Phe Gly Leu Val Ile Gln Gln Val 
             180                185                190
Phe Asp Asn Gly Ser Ile Tyr Asn Pro Glu Val Leu Asp Ile Thr Glu 
         195                200                205
Glu Thr Leu His Ser Arg Phe Leu Glu Gly Val Arg Asn Val Ala Ser 
     210                215                220
Val Cys Leu Gln Ile Gly Tyr Pro Thr Val Ala Ser Val Pro His Ser 
 225                230                235                240
Ile Ile Asn Gly Tyr Lys Arg Val Leu Ala Leu Ser Val Glu Thr Asp 
                 245                250                255
Tyr Thr Phe Pro Leu Ala Glu Lys Val Lys Ala Phe Leu Ala Asp Pro 
             260                265                270
Ser Ala Phe Val Ala Ala Ala Pro Val Ala Ala Ala Thr Thr Ala Ala 
         275                280                285
Pro Ala Ala Ala Ala Ala Pro Ala Lys Val Glu Ala Lys Glu Glu Ser 
     290                295                300
Glu Glu Ser Asp Glu Asp Met Gly Phe Gly Leu Phe Asp 
 305                310                315



<210> 9830
<211> 2615
<212> DNA
<213> Rattus norvegicus
<308> X63143
<400> 9830

cttcgagag  cagccatgc  gttcattcc  gacatagcc  tggctgcac  caccgcacc  60
gccatgcta  ccacgaccg  tatccagcc  gtggatacc  cgtttgagg  actcctttc  120
gagcatccc  gccccgaac  agtcaccag  cccccactg  tgacagagg  gacagaagt  180
gtggaagag  ccagtcaga  agccaccac  atctccacc  ccacatcta  cactgcagc  240
accaccaca  gggccccaa  tatggccac  gcacctgct  cagcagcca  cactgcccc  300
agcactccc  cggcacccc  tgccacggc  accacggct  acataagga  caccggcat  360
caagggctg  tgcctcttc  cctgaccac  gctgccaca  ccaaggcca  taccccagc  420
gtaccctca  cacccacta  tgtgactac  ttggacaca  aggccccga  acctaggct  480
gtcaacaca  ctacctctc  gccacgagc  cttcctcgg  cagtcacca  ccaggagcc  540
gaagttgct  agaggagta  cctgccgtt  gggaccacc  ctcctggac  cacagaggt  600
gctcagacc  caactccag  gtcccttct  accacgacc  aggatgagc  agaggtgcc  660
gtaagcggg  ggcccagcg  ggactttga  ctgcaagaa  agaccacac  gccagacac  720
gccaatgaa  tggtggcgg  ggaaggagc  gcggccaag  catcacctc  actggggac  780
ctacccaag  gtgcccgcc  aggccttgg  ctccacgac  atgccatcg  ctcgggcag  840
tctgctgcc  agctccctc  gaagagcat  ctagagcgg  aggaggtgc  cgtagctgt  900
atcgtaggt  gcgtggtgg  cgccctctt  gctgccttc  tggtcacgt  gctcatcta  960
cgcatgaag  agaaggacg  aggcagcta  accttggaa  agcccaagc  ggcaagcgt  1020
acataccag  agcccgaca  gcaggagga  ttctacgct  agcagagag  gccacagtg  1080
ctcctgcag  ctcgactcc  ccttgccca  tccctgtcc  aacaacagc  cagnccaat  1140
ctgggcctg  gcctgggcc  gggatggag  ctggccctg  ttccttctg  tcaggctgc  1200
agcttaaca  agactgtcc  aaggagcag  ggcgccacc  tctgcccca  actgtgccc  1260
tatgacccc  tctctaggc  cattccctc  agcctgggg  ttcaggatc  tgagtccca  1320
ggacaagag  aaggaagcc  tggttgctg  ttgaaacat  ggcggggcc  gggttaaga  1380
ggcccacag  gctcttcac  cagaggcca  catgctggc  tctaaaacc  acacatggt  1440
catctagcc  tccaattca  catcatccg  atgctgagg  ctcgagctg  tgtccaagg  1500
ctctctcga  aggagggtg  cctttgtca  cagcctgag  cgtcgtgga  tcaccgccc  1560
ctctcccct  cctaatgca  atgtcccca  gctgcacct  tttctgcac  tcctcccag  1620
gaaagggct  cctcagtgc  cagggcagt  agtggtaag  gaggccact  tagcgtccc  1680
cctgagagg  gatgtcaca  cgcctttgt  aaccactgc  ataatccta  aatgcattc  1740
cacaggaga  aaaaacata  ccagtcctg  ccacccggc  agcgagaca  cacacacac  1800
caccacctt  acgcagtct  agacatcct  acgcttctg  cacgtaggc  actgtcatc  1860
tcaccagtg  caaccacgc  accttcctc  cactctctc  ttacacaca  tggtcctgc  1920
tctggctcc  ctaaccatc  gggtcactg  ggaaggcag  accgagttg  aggcatcag  1980
ccatattgg  tcccccaga  tcaccctat  ccacttggt  cccaccatg  cacctatac  2040
agccacact  atgctgatc  cagctgatg  cagtcacaa  cccacacag  tgcaggctc  2100
ccctcccca  tgtggctca  agagaagtt  tgggctagc  tctgccagc  aagtctgaa  2160
gaagaaggg  gctagggtc  cccaggacc  aggagctgt  tgggttgtc  ctggtctct  2220
tgtatttcc  ttctgctct  agccaggag  tgtctctgc  tcccaggac  cgtgtctcc  2280
aagtgcctg  gagggcggg  tccgcccag  ccctctgtg  cccctgccc  gccctggcc  2340
ggtgagacc  acctcaggc  tacctactc  gggtcctct  tgtggacac  actgaccag  2400
caacttggc  gttctggct  caactggat  gactcatac  ccagcaggc  catcccaat  2460
ctgtaggcc  caagagtca  tgatgggga  aagggtgtc  caggcctca  gtctaccac  2520
ctgtctctg  tattcttag  agtggggct  ttccagagg  attttaagt  tgggatcac  2580
attctcttt  tgagagggg  gtgccgagg  aattc  2615



<210> 9831
<211> 442
<212> PRT
<213> Rattus norvegicus
<308> CAA44848
<400> 9831

Met Lys Pro Gly Pro Pro Arg Arg Gly Thr Ala Gln Gly Gln Arg Val 
  1               5                  10                  15
Asp Thr Ala Thr His Gly Pro Gly Ala Arg Gly Leu Leu Leu Pro Pro 
             20                  25                  30
Leu Leu Leu Leu Leu Leu Ala Gly Arg Ala Ala Gly Ala Gln Arg Trp 
         35                  40                  45
Arg Asn Glu Asn Phe Glu Arg Pro Val Asp Leu Glu Gly Ser Gly Asp 
     50                  55                  60
Asp Asp Ser Phe Pro Asp Asp Glu Leu Asp Asp Leu Tyr Ser Gly Ser 
 65                  70                  75                  80
Gly Ser Gly Tyr Phe Glu Gln Glu Ser Gly Leu Glu Thr Ala Met Arg 
                 85                  90                  95
Phe Ile Pro Asp Ile Ala Leu Ala Ala Pro Thr Ala Pro Ala Met Leu 
             100                105                110
Pro Thr Thr Val Ile Gln Pro Val Asp Thr Pro Phe Glu Glu Leu Leu 
         115                120                125
Ser Glu His Pro Gly Pro Glu Pro Val Thr Ser Pro Pro Leu Val Thr 
     130                135                140
Glu Val Thr Glu Val Val Glu Glu Pro Ser Gln Arg Ala Thr Thr Ile 
 145                150                155                160
Ser Thr Thr Thr Ser Thr Thr Ala Ala Thr Thr Thr Gly Ala Pro Thr 
                 165                170                175
Met Ala Thr Ala Pro Ala Thr Ala Ala Thr Thr Ala Pro Ser Thr Pro 
             180                185                190
Ala Ala Pro Pro Ala Thr Ala Thr Thr Ala Asp Ile Arg Thr Thr Gly 
         195                200                205
Ile Gln Gly Leu Leu Pro Leu Pro Leu Thr Thr Ala Ala Thr Ala Lys 
     210                215                220
Ala Thr Thr Pro Ala Val Pro Ser Pro Pro Thr Thr Val Thr Thr Leu 
 225                230                235                240
Asp Thr Glu Ala Pro Thr Pro Arg Leu Val Asn Thr Ala Thr Ser Arg 
                 245                250                255
Pro Arg Ala Leu Pro Arg Pro Val Thr Thr Gln Glu Pro Glu Val Ala 
             260                265                270
Glu Arg Ser Thr Leu Pro Leu Gly Thr Thr Ala Pro Gly Pro Thr Glu 
         275                280                285
Val Ala Gln Thr Pro Thr Pro Glu Ser Leu Leu Thr Thr Thr Gln Asp 
     290                295                300
Glu Pro Glu Val Pro Val Ser Gly Gly Pro Ser Gly Asp Phe Glu Leu 
 305                310                315                320
Gln Glu Glu Thr Thr Gln Pro Asp Thr Ala Asn Glu Val Val Ala Val 
                 325                330                335
Glu Gly Ala Ala Ala Lys Pro Ser Pro Pro Leu Gly Thr Leu Pro Lys 
             340                345                350
Gly Ala Arg Pro Gly Leu Gly Leu His Asp Asn Ala Ile Asp Ser Gly 
         355                360                365
Ser Ser Ala Ala Gln Leu Pro Gln Lys Ser Ile Leu Glu Arg Lys Glu 
     370                375                380
Val Leu Val Ala Val Ile Val Gly Gly Val Val Gly Ala Leu Phe Ala 
 385                390                395                400
Ala Phe Leu Val Thr Leu Leu Ile Tyr Arg Met Lys Lys Lys Asp Glu 
                 405                410                415
Gly Ser Tyr Thr Leu Glu Glu Pro Lys Gln Ala Ser Val Thr Tyr Gln 
             420                425                430
Lys Pro Asp Lys Gln Glu Glu Phe Tyr Ala 
         435                440



<210> 9832
<211> 1463
<212> DNA
<213> Homo sapiens
<308> AF248634
<400> 9832

gaattccac  aaggcgccc  cccgccgcc  gccgcccgc  cccgcgccg  cgccatgaa  60
ccggggccg  cgcaccgtg  cggggccgc  cacggggcc  gcgccgggg  cggggccgc  120
gccgggccc  gggcccgcg  gctgctcct  ccaccgctg  tgctgctgc  gctggcggg  180
cgcgccgcg  gggcccagc  ctggcgcag  gagaacttc  agagacccg  ggacctgga  240
ggctctggg  atgatgact  ctttcccga  gatgaactg  atgacctct  ctcggggtc  300
ggctcgggc  acttcgagc  ggagtcggg  attgagaca  ccatgcgct  cagcccaga  360
gtagccctg  cggtgtcca  cacacctgc  gtgctgccc  ccacgaaca  ccagcctgt  420
ggcacacca  ttgaagagc  cccctctga  cgccccacc  tggagccag  caccagccc  480
ctggtggtg  cagaagtcc  ggaagagcc  agccagaga  ccaccaccg  ctccactac  540
atggctacc  ctgctgcca  aagcacagg  gacccgact  tggccacag  gcctgccac  600
gtggccacc  ccaccccca  cacccctgc  gcaccccct  ttacggcca  cactgctgt  660
ataaggacc  ctggcgtac  gaggcttct  cctctccca  tgaccacag  ggctacggc  720
cgggccact  cccccgagg  gccctcccc  cccaccacg  cggctgtct  ggacaccga  780
gccccaaca  ccaggctgg  cagcacagc  acctcccgg  caagagccc  tcccaggcc  840
gccaccacc  aggagcctg  catccctga  aggagcacc  tgcccctgg  gaccactgc  900
cctggaccc  cagaggtgg  tcagacccc  actccagag  ccttcctga  cacaatccg  960
aatgagcca  aggttccgg  gagtggggg  cccagtgga  acttcgagc  gccagaaga  1020
gagaccaca  aaccagaca  agccaatga  gtggtagct  tgggagggg  tgcggccaa  1080
gcatcatct  cacctggga  actgcccaa  ggtgcccgc  cgggccctg  cctcctgga  1140
aatgccatc  actcgggca  ctcagctgc  cagctgcct  agaagagta  cctggagcg  1200
aaggaggtg  tcgtagctg  gattgtggg  ggggtggtg  gcgccctct  tgctgcctt  1260
ttggtcaca  tgctcatct  tcgtatgaa  aaaaaggat  agggcagct  cacgctgga  1320
gaacccaag  aggcgagcg  cacatacca  aagcctgac  agcaggagg  gttctatgc  1380
tagtggagc  acagtgcct  cctgcagcc  caacaccac  ctgctgtcc  gtccccagc  1440
tggccccac  agcccaagc  cct  1463



<210> 9833
<211> 384
<212> PRT
<213> Homo sapiens
<308> O75056
<400> 9833

Met Ala Ile Ala Tyr Leu Gly Ser Ser Cys Pro Ser Gln Pro Pro Ser 
  1               5                  10                  15
Ser Leu Ala Leu Ser Leu Ser Pro Thr Pro Ser Asp Phe Glu Gln Glu 
             20                  25                  30
Ser Gly Ile Glu Thr Ala Met Arg Phe Ser Pro Asp Val Ala Leu Ala 
         35                  40                  45
Val Ser Thr Thr Pro Ala Val Leu Pro Thr Thr Asn Ile Gln Pro Val 
     50                  55                  60
Gly Thr Pro Phe Glu Glu Leu Pro Ser Glu Arg Pro Thr Leu Glu Pro 
 65                  70                  75                  80
Ala Thr Ser Pro Leu Val Val Thr Glu Val Pro Glu Glu Pro Ser Gln 
                 85                  90                  95
Arg Ala Thr Thr Val Ser Thr Thr Met Ala Thr Thr Ala Ala Thr Ser 
             100                105                110
Thr Gly Asp Pro Thr Val Ala Thr Val Pro Ala Thr Val Ala Thr Ala 
         115                120                125
Thr Pro Ser Thr Pro Ala Ala Pro Pro Phe Thr Ala Thr Thr Ala Val 
     130                135                140
Ile Arg Thr Thr Gly Val Arg Arg Leu Leu Pro Leu Pro Leu Thr Thr 
 145                150                155                160
Val Ala Thr Ala Arg Ala Thr Thr Pro Glu Ala Pro Ser Pro Pro Thr 
                 165                170                175
Thr Ala Ala Val Leu Asp Thr Glu Ala Pro Thr Pro Arg Leu Val Ser 
             180                185                190
Thr Ala Thr Ser Arg Pro Arg Ala Leu Pro Arg Pro Ala Thr Thr Gln 
         195                200                205
Glu Pro Asp Ile Pro Glu Arg Ser Thr Leu Pro Leu Gly Thr Thr Ala 
     210                215                220
Pro Gly Pro Thr Glu Val Ala Gln Thr Pro Thr Pro Glu Thr Phe Leu 
 225                230                235                240
Thr Thr Ile Arg Asp Glu Pro Glu Val Pro Val Ser Gly Gly Pro Ser 
                 245                250                255
Gly Asp Phe Glu Leu Pro Glu Glu Glu Thr Thr Gln Pro Asp Thr Ala 
             260                265                270
Asn Glu Val Val Ala Val Gly Gly Ala Ala Ala Lys Ala Ser Ser Pro 
         275                280                285
Pro Gly Thr Leu Pro Lys Gly Ala Arg Pro Gly Pro Gly Leu Leu Asp 
     290                295                300
Asn Ala Ile Asp Ser Gly Ser Ser Ala Ala Gln Leu Pro Gln Lys Ser 
 305                310                315                320
Ile Leu Glu Arg Lys Glu Val Leu Val Ala Val Ile Val Gly Gly Val 
                 325                330                335
Val Gly Ala Leu Phe Ala Ala Phe Leu Val Thr Leu Leu Ile Tyr Arg 
             340                345                350
Met Lys Lys Lys Asp Glu Gly Ser Tyr Thr Leu Glu Glu Pro Lys Gln 
         355                360                365
Ala Ser Val Thr Tyr Gln Lys Pro Asp Lys Gln Glu Glu Phe Tyr Ala 
     370                375                380



<210> 9834
<211> 1890
<212> DNA
<213> Rattus norvegicus
<308> X63375
<400> 9834

gaattctac  gtatagggt  ggggtgccc  cagtgagat  taacaataa  ccaacggga  60
gaccagcca  agacctggg  tgggagagt  ttaggtggc  gggtcacgt  cataaattg  120
tccccgggg  ctagactgg  aggagccac  accggttac  agctacagc  cagggtggg  180
ttggcaatt  tccggattg  ggtggttca  gccgcccac  agaagcaca  accaggagt  240
aggaaccga  gctgcccgc  gggctggcc  gcaggagag  gacgggccg  aactgcaac  300
gcagtggca  agagtgcga  ggggcggca  gtgcacaag  agagaggcg  agcagagct  360
ggcagagtc  ctagcgtcc  ggagtgacc  tcccccacc  agccagggc  tagggaagg  420
ggacttgca  taaacccaa  ccaggagta  gggggtaag  ccaatagga  gaagggatt  480
gggtctccg  ggctcccag  gagcgacgc  ggtggaggc  acagcatcg  cgcccgcac  540
gggggcaag  gtgggttgt  caggcacag  ttggggcgg  gagagggcc  gcagagctt  600
gggagcact  ctcactcac  ccaagtccc  ctccgcacc  ctgctgctg  gccagcccc  660
ctagcctag  cggctcctt  gtgccggcc  cacgcccgc  ccttcgggc  caggcccgc  720
ttctcggca  cggcgattg  cctgcggtg  cgccggtag  cggagctac  gatggtgga  780
gcgcggtat  tagtaaagg  agggcgtgc  ccctcagcc  atttctcct  ctgctggcc  840
gcgcgcccg  gtgccgagc  cgcgctcca  tcctttcgt  cttcccggt  actttccct  900
cttgtccct  gtccatctc  ccagaggtc  tagcaggca  agtggtgca  ctacagctt  960
aagcagcag  tgcggggtt  gctgagccc  ccgggaggc  atcggagcg  ggggagagc  1020
ggagtgcgg  cacgcgccc  cctctaggt  cggggctcg  agccgccca  cccgcgcgc  1080
ccctcctcc  tcctccctc  tccctccgc  cccgccgca  ctccccctc  tcccgctct  1140
cttaggctg  tccgcggcg  gcctcgcac  cggagagcc  cagcggcag  ggcgcgtct  1200
gcctttgga  acagagccg  gccgcgggg  caccgagca  tcgccgcga  gacgccagg  1260
cgcgcgcag  actcgcttt  cctcggcct  ggccgccac  gctgagcag  caccatggc  1320
cgcggaaaa  ccaaggagg  aggcagctg  aagaaattc  tctggaact  ggagaagaa  1380
gagtttttg  gcaggaccg  tggtagttg  tgtaagtaa  cgctcccgg  tttcgccgt  1440
ggcccttgg  tttttctag  aggcgcatc  gtgtacgcg  cactgcgga  agttcggcg  1500
ccacgggct  tccagggtg  tggggattg  tggtaggcg  tgctaggag  gcgcggcct  1560
ggcttggca  ccagtgaca  atgcagggg  tcctcagaa  gcggcttgg  ttgggagct  1620
aagctagct  gactgaagg  tttgcgatg  tagggaatc  tcggtcagg  tcctccctc  1680
ccatcccca  agaccttag  aaaatgaga  ttggggctg  gagcagaac  catgagctt  1740
cctgttcta  tgcagacga  gctgcgata  catcattct  ccagcctag  actgtatct  1800
gaatggaga  gaacgggga  gagaaatgc  cccacactg  aatcctcat  cactgcaat  1860
ttcgcagcc  agaaatggc  cagtgagctc  1890



<210> 9835
<211> 304
<212> PRT
<213> Rattus norvegicus
<308> AAA40780
<400> 9835

Met Ala Arg Gly Lys Ala Lys Glu Glu Gly Ser Trp Lys Lys Phe Ile 
  1               5                  10                  15
Trp Asn Ser Glu Lys Lys Glu Phe Leu Gly Arg Thr Gly Gly Ser Trp 
             20                  25                  30
Phe Lys Ile Leu Leu Phe Tyr Val Ile Phe Tyr Gly Cys Leu Ala Gly 
         35                  40                  45
Ile Phe Ile Gly Thr Ile Gln Val Met Leu Leu Thr Ile Ser Glu Leu 
     50                  55                  60
Lys Pro Thr Tyr Gln Asp Arg Val Ala Pro Pro Gly Leu Thr Gln Ile 
 65                  70                  75                  80
Pro Gln Ile Gln Lys Thr Glu Ile Ser Phe Arg Pro Asn Asp Pro Lys 
                 85                  90                  95
Ser Tyr Glu Ala Tyr Val Leu Asn Ile Ile Arg Phe Leu Glu Lys Tyr 
             100                105                110
Lys Asp Ser Ala Gln Lys Asp Asp Met Ile Phe Glu Asp Cys Gly Ser 
         115                120                125
Met Pro Ser Glu Pro Lys Glu Arg Gly Glu Phe Asn His Glu Arg Gly 
     130                135                140
Glu Arg Lys Val Cys Arg Phe Lys Leu Asp Trp Leu Gly Asn Cys Ser 
 145                150                155                160
Gly Leu Asn Asp Glu Ser Tyr Gly Tyr Lys Glu Gly Lys Pro Cys Ile 
                 165                170                175
Ile Ile Lys Leu Asn Arg Val Leu Gly Phe Lys Pro Lys Pro Pro Lys 
             180                185                190
Asn Glu Ser Leu Glu Thr Tyr Pro Leu Thr Met Lys Tyr Asn Pro Asn 
         195                200                205
Val Leu Pro Val Gln Cys Thr Gly Lys Arg Asp Glu Asp Lys Asp Lys 
     210                215                220
Val Gly Asn Ile Glu Tyr Phe Gly Met Gly Gly Phe Tyr Gly Phe Pro 
 225                230                235                240
Leu Gln Tyr Tyr Pro Tyr Tyr Gly Lys Leu Leu Gln Pro Lys Tyr Leu 
                 245                250                255
Gln Pro Leu Leu Ala Val Gln Phe Thr Asn Leu Thr Leu Asp Thr Glu 
             260                265                270
Ile Arg Ile Glu Cys Lys Ala Tyr Gly Glu Asn Ile Gly Tyr Ser Glu 
         275                280                285
Lys Asp Arg Phe Gln Gly Arg Phe Asp Val Lys Ile Glu Val Lys Ser 
     290                295                300



<210> 9836
<211> 2208
<212> DNA
<213> Homo sapiens
<308> NM_001677
<400> 9836

gaattcatg  taaattgct  gaaggctgc  tctctgctg  ggtgtcagt  ccggatgcc  60
catcgccag  ggcgcgccg  agccaccca  cctccggac  gcggcagct  ctgacccgc  120
atcgccatg  cccgcggga  agccaagga  gagggcagc  ggaagaaat  catctggaa  180
tcagagaag  aggagtttc  gggcaggac  ggtggcagt  ggtttaaga  ccttctatt  240
tacgtaata  tttatggct  cctggctgg  atcttcatc  gaaccatcc  agtgatgct  300
ctcaccatc  gtgaattta  gcccacata  caggaccga  tggccccgc  aggattaac  360
cagattcct  agatccaga  gactgaaat  tcctttcgt  ctaatgatc  caagagcta  420
gaggcatat  tactgaaca  agttaggtt  ctggaaaag  acaaagatt  agcccagag  480
gatgacatg  tttttgaag  ttgtggcga  gtgcccagt  aaccgaaag  acgaggaga  540
tttaatcat  aacgaggag  gcgaaaggt  tgcagattc  agcttgaat  gctgggaaa  600
tgctctgga  taaatgatg  aacttatgg  tacaaagag  gcaaaccgt  cattattat  660
aagctcaac  gagttctag  cttcaaacc  aagcctccc  agaatgagt  cttggagac  720
tacccagtg  tgaagtata  cccaaatgt  cttcccgtt  agtgcactg  caagcgaga  780
gaagataag  ataaagttg  aaatgtgga  tattttgga  tgggcaact  ccctggttt  840
cctctgcag  attatccgt  ctatggcaa  ctcctgcag  ccaaatacc  gcagcccct  900
ctggccgta  agttcacca  tcttaccat  gacactgaa  ttcgcatag  gtgtaaggc  960
tacggtgag  acattgggt  cagtgagaa  gaccgtttt  agggacgtt  tgatgtaaa  1020
attgaagtt  agagctgat  acaagcaca  atctttccc  ctagccatt  aataagtta  1080
aaaaagata  aaaaacaaa  acctactag  cttgaacaa  ctgtcatac  tatgggacc  1140
acacttaat  tatatgctt  acactagct  tctgcattt  ataggttag  atgtaaatt  1200
aagtgtagc  atagcaaca  aatatttat  ctactgtaa  tgacaaaag  aaaagaaaa  1260
ttgagcctt  ggacgtgcc  atttttact  taaattatg  ttccgtaac  gaccttgta  1320
taagcagtg  ttctggccc  taagtattg  tgccttgtg  attttattt  gtgtacagt  1380
ctacaggtg  atactctgg  catttttca  gccatgttt  attgtatct  ttttctact  1440
tatgtgagc  aggtttgct  tccaaggtg  aaatattca  cgggaataa  actggcatg  1500
taatttttt  tttttgttt  ttttttgtt  tttggctct  tcaaaggta  tggcccatc  1560
atgagcatt  ttaacatac  ccatagtct  ttcctgtgg  gttaggtct  tatttttat  1620
tttttcctg  gggctgggg  gggggtttg  catggggga  ctgcccttt  aattttaag  1680
gacactaca  aaaaacaca  aaaggtgat  ggttgtgtt  tgcttgtat  gaatgctgt  1740
ttgacatct  ttgccttgt  ctccggtat  ttctaaagc  gtgtctgag  tctggatct  1800
cccatcact  tggcctagg  acagggcta  ttaatttgc  ttatacatt  tcttttact  1860
tcctttttt  ctttctgga  gcatcacat  ctggtgctg  gtctttatg  atgttttaa  1920
cattttcat  gtggaagaa  tttatattt  tgcagttgt  caattttat  tttttctgc  1980
agaaaaagt  taatgtatg  aataaacca  agtcacttg  ttgaaaata  atctttatt  2040
tgaacttta  aaaagcaat  cagtacccc  tagactggt  ttaaatgtt  tctacagtg  2100
aaaatccat  ttctaacat  tgtaataat  gccaggagt  cagtgctct  gttgatctt  2160
tattcagtc  ggttaaaac  acggacaat  aaagaatga  ccgaattc  2208



<210> 9837
<211> 303
<212> PRT
<213> Homo sapiens
<308> P05026
<400> 9837

Met Ala Arg Gly Lys Ala Lys Glu Glu Gly Ser Trp Lys Lys Phe Ile 
  1               5                  10                  15
Trp Asn Ser Glu Lys Lys Glu Phe Leu Gly Arg Thr Gly Gly Ser Trp 
             20                  25                  30
Phe Lys Ile Leu Leu Phe Tyr Val Ile Phe Tyr Gly Cys Leu Ala Gly 
         35                  40                  45
Ile Phe Ile Gly Thr Ile Gln Val Met Leu Leu Thr Ile Ser Glu Phe 
     50                  55                  60
Lys Pro Thr Tyr Gln Asp Arg Val Ala Pro Pro Gly Leu Thr Gln Ile 
 65                  70                  75                  80
Pro Gln Ile Gln Lys Thr Glu Ile Ser Phe Arg Pro Asn Asp Pro Lys 
                 85                  90                  95
Ser Tyr Glu Ala Tyr Val Leu Asn Ile Val Arg Phe Leu Glu Lys Tyr 
             100                105                110
Lys Asp Ser Ala Gln Arg Asp Asp Met Ile Phe Glu Asp Cys Gly Asp 
         115                120                125
Val Pro Ser Glu Pro Lys Glu Arg Gly Asp Phe Asn His Glu Arg Gly 
     130                135                140
Glu Arg Lys Val Cys Arg Phe Lys Leu Glu Trp Leu Gly Asn Cys Ser 
 145                150                155                160
Gly Leu Asn Asp Glu Thr Tyr Gly Tyr Lys Glu Gly Lys Pro Cys Ile 
                 165                170                175
Ile Ile Lys Leu Asn Arg Val Leu Gly Phe Lys Pro Lys Pro Pro Lys 
             180                185                190
Asn Glu Ser Leu Glu Thr Tyr Pro Val Met Lys Tyr Asn Pro Asn Val 
         195                200                205
Leu Pro Val Gln Cys Thr Gly Lys Arg Asp Glu Asp Lys Asp Lys Val 
     210                215                220
Gly Asn Val Glu Tyr Phe Gly Leu Gly Asn Ser Pro Gly Phe Pro Leu 
 225                230                235                240
Gln Tyr Tyr Pro Tyr Tyr Gly Lys Leu Leu Gln Pro Lys Tyr Leu Gln 
                 245                250                255
Pro Leu Leu Ala Val Gln Phe Thr Asn Leu Thr Met Asp Thr Glu Ile 
             260                265                270
Arg Ile Glu Cys Lys Ala Tyr Gly Glu Asn Ile Gly Tyr Ser Glu Lys 
         275                280                285
Asp Arg Phe Gln Gly Arg Phe Asp Val Lys Ile Glu Val Lys Ser 
     290                295                300



<210> 9838
<211> 1890
<212> DNA
<213> Rattus norvegicus
<308> X63375
<400> 9838

gaattctac  gtatagggt  ggggtgccc  cagtgagat  taacaataa  ccaacggga  60
gaccagcca  agacctggg  tgggagagt  ttaggtggc  gggtcacgt  cataaattg  120
tccccgggg  ctagactgg  aggagccac  accggttac  agctacagc  cagggtggg  180
ttggcaatt  tccggattg  ggtggttca  gccgcccac  agaagcaca  accaggagt  240
aggaaccga  gctgcccgc  gggctggcc  gcaggagag  gacgggccg  aactgcaac  300
gcagtggca  agagtgcga  ggggcggca  gtgcacaag  agagaggcg  agcagagct  360
ggcagagtc  ctagcgtcc  ggagtgacc  tcccccacc  agccagggc  tagggaagg  420
ggacttgca  taaacccaa  ccaggagta  gggggtaag  ccaatagga  gaagggatt  480
gggtctccg  ggctcccag  gagcgacgc  ggtggaggc  acagcatcg  cgcccgcac  540
gggggcaag  gtgggttgt  caggcacag  ttggggcgg  gagagggcc  gcagagctt  600
gggagcact  ctcactcac  ccaagtccc  ctccgcacc  ctgctgctg  gccagcccc  660
ctagcctag  cggctcctt  gtgccggcc  cacgcccgc  ccttcgggc  caggcccgc  720
ttctcggca  cggcgattg  cctgcggtg  cgccggtag  cggagctac  gatggtgga  780
gcgcggtat  tagtaaagg  agggcgtgc  ccctcagcc  atttctcct  ctgctggcc  840
gcgcgcccg  gtgccgagc  cgcgctcca  tcctttcgt  cttcccggt  actttccct  900
cttgtccct  gtccatctc  ccagaggtc  tagcaggca  agtggtgca  ctacagctt  960
aagcagcag  tgcggggtt  gctgagccc  ccgggaggc  atcggagcg  ggggagagc  1020
ggagtgcgg  cacgcgccc  cctctaggt  cggggctcg  agccgccca  cccgcgcgc  1080
ccctcctcc  tcctccctc  tccctccgc  cccgccgca  ctccccctc  tcccgctct  1140
cttaggctg  tccgcggcg  gcctcgcac  cggagagcc  cagcggcag  ggcgcgtct  1200
gcctttgga  acagagccg  gccgcgggg  caccgagca  tcgccgcga  gacgccagg  1260
cgcgcgcag  actcgcttt  cctcggcct  ggccgccac  gctgagcag  caccatggc  1320
cgcggaaaa  ccaaggagg  aggcagctg  aagaaattc  tctggaact  ggagaagaa  1380
gagtttttg  gcaggaccg  tggtagttg  tgtaagtaa  cgctcccgg  tttcgccgt  1440
ggcccttgg  tttttctag  aggcgcatc  gtgtacgcg  cactgcgga  agttcggcg  1500
ccacgggct  tccagggtg  tggggattg  tggtaggcg  tgctaggag  gcgcggcct  1560
ggcttggca  ccagtgaca  atgcagggg  tcctcagaa  gcggcttgg  ttgggagct  1620
aagctagct  gactgaagg  tttgcgatg  tagggaatc  tcggtcagg  tcctccctc  1680
ccatcccca  agaccttag  aaaatgaga  ttggggctg  gagcagaac  catgagctt  1740
cctgttcta  tgcagacga  gctgcgata  catcattct  ccagcctag  actgtatct  1800
gaatggaga  gaacgggga  gagaaatgc  cccacactg  aatcctcat  cactgcaat  1860
ttcgcagcc  agaaatggc  cagtgagctc  1890



<210> 9839
<211> 304
<212> PRT
<213> Rattus norvegicus
<308> AAA40780
<400> 9839

Met Ala Arg Gly Lys Ala Lys Glu Glu Gly Ser Trp Lys Lys Phe Ile 
  1               5                  10                  15
Trp Asn Ser Glu Lys Lys Glu Phe Leu Gly Arg Thr Gly Gly Ser Trp 
             20                  25                  30
Phe Lys Ile Leu Leu Phe Tyr Val Ile Phe Tyr Gly Cys Leu Ala Gly 
         35                  40                  45
Ile Phe Ile Gly Thr Ile Gln Val Met Leu Leu Thr Ile Ser Glu Leu 
     50                  55                  60
Lys Pro Thr Tyr Gln Asp Arg Val Ala Pro Pro Gly Leu Thr Gln Ile 
 65                  70                  75                  80
Pro Gln Ile Gln Lys Thr Glu Ile Ser Phe Arg Pro Asn Asp Pro Lys 
                 85                  90                  95
Ser Tyr Glu Ala Tyr Val Leu Asn Ile Ile Arg Phe Leu Glu Lys Tyr 
             100                105                110
Lys Asp Ser Ala Gln Lys Asp Asp Met Ile Phe Glu Asp Cys Gly Ser 
         115                120                125
Met Pro Ser Glu Pro Lys Glu Arg Gly Glu Phe Asn His Glu Arg Gly 
     130                135                140
Glu Arg Lys Val Cys Arg Phe Lys Leu Asp Trp Leu Gly Asn Cys Ser 
 145                150                155                160
Gly Leu Asn Asp Glu Ser Tyr Gly Tyr Lys Glu Gly Lys Pro Cys Ile 
                 165                170                175
Ile Ile Lys Leu Asn Arg Val Leu Gly Phe Lys Pro Lys Pro Pro Lys 
             180                185                190
Asn Glu Ser Leu Glu Thr Tyr Pro Leu Thr Met Lys Tyr Asn Pro Asn 
         195                200                205
Val Leu Pro Val Gln Cys Thr Gly Lys Arg Asp Glu Asp Lys Asp Lys 
     210                215                220
Val Gly Asn Ile Glu Tyr Phe Gly Met Gly Gly Phe Tyr Gly Phe Pro 
 225                230                235                240
Leu Gln Tyr Tyr Pro Tyr Tyr Gly Lys Leu Leu Gln Pro Lys Tyr Leu 
                 245                250                255
Gln Pro Leu Leu Ala Val Gln Phe Thr Asn Leu Thr Leu Asp Thr Glu 
             260                265                270
Ile Arg Ile Glu Cys Lys Ala Tyr Gly Glu Asn Ile Gly Tyr Ser Glu 
         275                280                285
Lys Asp Arg Phe Gln Gly Arg Phe Asp Val Lys Ile Glu Val Lys Ser 
     290                295                300



<210> 9840
<211> 2208
<212> DNA
<213> Homo sapiens
<308> NM_001677
<400> 9840

gaattcatg  taaattgct  gaaggctgc  tctctgctg  ggtgtcagt  ccggatgcc  60
catcgccag  ggcgcgccg  agccaccca  cctccggac  gcggcagct  ctgacccgc  120
atcgccatg  cccgcggga  agccaagga  gagggcagc  ggaagaaat  catctggaa  180
tcagagaag  aggagtttc  gggcaggac  ggtggcagt  ggtttaaga  ccttctatt  240
tacgtaata  tttatggct  cctggctgg  atcttcatc  gaaccatcc  agtgatgct  300
ctcaccatc  gtgaattta  gcccacata  caggaccga  tggccccgc  aggattaac  360
cagattcct  agatccaga  gactgaaat  tcctttcgt  ctaatgatc  caagagcta  420
gaggcatat  tactgaaca  agttaggtt  ctggaaaag  acaaagatt  agcccagag  480
gatgacatg  tttttgaag  ttgtggcga  gtgcccagt  aaccgaaag  acgaggaga  540
tttaatcat  aacgaggag  gcgaaaggt  tgcagattc  agcttgaat  gctgggaaa  600
tgctctgga  taaatgatg  aacttatgg  tacaaagag  gcaaaccgt  cattattat  660
aagctcaac  gagttctag  cttcaaacc  aagcctccc  agaatgagt  cttggagac  720
tacccagtg  tgaagtata  cccaaatgt  cttcccgtt  agtgcactg  caagcgaga  780
gaagataag  ataaagttg  aaatgtgga  tattttgga  tgggcaact  ccctggttt  840
cctctgcag  attatccgt  ctatggcaa  ctcctgcag  ccaaatacc  gcagcccct  900
ctggccgta  agttcacca  tcttaccat  gacactgaa  ttcgcatag  gtgtaaggc  960
tacggtgag  acattgggt  cagtgagaa  gaccgtttt  agggacgtt  tgatgtaaa  1020
attgaagtt  agagctgat  acaagcaca  atctttccc  ctagccatt  aataagtta  1080
aaaaagata  aaaaacaaa  acctactag  cttgaacaa  ctgtcatac  tatgggacc  1140
acacttaat  tatatgctt  acactagct  tctgcattt  ataggttag  atgtaaatt  1200
aagtgtagc  atagcaaca  aatatttat  ctactgtaa  tgacaaaag  aaaagaaaa  1260
ttgagcctt  ggacgtgcc  atttttact  taaattatg  ttccgtaac  gaccttgta  1320
taagcagtg  ttctggccc  taagtattg  tgccttgtg  attttattt  gtgtacagt  1380
ctacaggtg  atactctgg  catttttca  gccatgttt  attgtatct  ttttctact  1440
tatgtgagc  aggtttgct  tccaaggtg  aaatattca  cgggaataa  actggcatg  1500
taatttttt  tttttgttt  ttttttgtt  tttggctct  tcaaaggta  tggcccatc  1560
atgagcatt  ttaacatac  ccatagtct  ttcctgtgg  gttaggtct  tatttttat  1620
tttttcctg  gggctgggg  gggggtttg  catggggga  ctgcccttt  aattttaag  1680
gacactaca  aaaaacaca  aaaggtgat  ggttgtgtt  tgcttgtat  gaatgctgt  1740
ttgacatct  ttgccttgt  ctccggtat  ttctaaagc  gtgtctgag  tctggatct  1800
cccatcact  tggcctagg  acagggcta  ttaatttgc  ttatacatt  tcttttact  1860
tcctttttt  ctttctgga  gcatcacat  ctggtgctg  gtctttatg  atgttttaa  1920
cattttcat  gtggaagaa  tttatattt  tgcagttgt  caattttat  tttttctgc  1980
agaaaaagt  taatgtatg  aataaacca  agtcacttg  ttgaaaata  atctttatt  2040
tgaacttta  aaaagcaat  cagtacccc  tagactggt  ttaaatgtt  tctacagtg  2100
aaaatccat  ttctaacat  tgtaataat  gccaggagt  cagtgctct  gttgatctt  2160
tattcagtc  ggttaaaac  acggacaat  aaagaatga  ccgaattc  2208



<210> 9841
<211> 303
<212> PRT
<213> Homo sapiens
<308> P05026
<400> 9841

Met Ala Arg Gly Lys Ala Lys Glu Glu Gly Ser Trp Lys Lys Phe Ile 
  1               5                  10                  15
Trp Asn Ser Glu Lys Lys Glu Phe Leu Gly Arg Thr Gly Gly Ser Trp 
             20                  25                  30
Phe Lys Ile Leu Leu Phe Tyr Val Ile Phe Tyr Gly Cys Leu Ala Gly 
         35                  40                  45
Ile Phe Ile Gly Thr Ile Gln Val Met Leu Leu Thr Ile Ser Glu Phe 
     50                  55                  60
Lys Pro Thr Tyr Gln Asp Arg Val Ala Pro Pro Gly Leu Thr Gln Ile 
 65                  70                  75                  80
Pro Gln Ile Gln Lys Thr Glu Ile Ser Phe Arg Pro Asn Asp Pro Lys 
                 85                  90                  95
Ser Tyr Glu Ala Tyr Val Leu Asn Ile Val Arg Phe Leu Glu Lys Tyr 
             100                105                110
Lys Asp Ser Ala Gln Arg Asp Asp Met Ile Phe Glu Asp Cys Gly Asp 
         115                120                125
Val Pro Ser Glu Pro Lys Glu Arg Gly Asp Phe Asn His Glu Arg Gly 
     130                135                140
Glu Arg Lys Val Cys Arg Phe Lys Leu Glu Trp Leu Gly Asn Cys Ser 
 145                150                155                160
Gly Leu Asn Asp Glu Thr Tyr Gly Tyr Lys Glu Gly Lys Pro Cys Ile 
                 165                170                175
Ile Ile Lys Leu Asn Arg Val Leu Gly Phe Lys Pro Lys Pro Pro Lys 
             180                185                190
Asn Glu Ser Leu Glu Thr Tyr Pro Val Met Lys Tyr Asn Pro Asn Val 
         195                200                205
Leu Pro Val Gln Cys Thr Gly Lys Arg Asp Glu Asp Lys Asp Lys Val 
     210                215                220
Gly Asn Val Glu Tyr Phe Gly Leu Gly Asn Ser Pro Gly Phe Pro Leu 
 225                230                235                240
Gln Tyr Tyr Pro Tyr Tyr Gly Lys Leu Leu Gln Pro Lys Tyr Leu Gln 
                 245                250                255
Pro Leu Leu Ala Val Gln Phe Thr Asn Leu Thr Met Asp Thr Glu Ile 
             260                265                270
Arg Ile Glu Cys Lys Ala Tyr Gly Glu Asn Ile Gly Tyr Ser Glu Lys 
         275                280                285
Asp Arg Phe Gln Gly Arg Phe Asp Val Lys Ile Glu Val Lys Ser 
     290                295                300



<210> 9842
<211> 1508
<212> DNA
<213> Rattus norvegicus
<308> X63594
<400> 9842

cccaactgc  agcagcctg  accctgcac  cgctcagct  cgcacagcc  tgtttcagc  60
agctgggca  ggccaggac  gggccatgg  gggcccgcg  gacggcctc  agaaggagc  120
gttggtgga  gaccgccac  acagcggct  ggactccat  aaggacgag  attacgagc  180
gatggtgaa  gagctgcgg  agatccgcc  gcagccgca  gaggcgcct  tggctgccg  240
gccctggaa  caacagctc  cggaggacg  agactcgtt  ctgcacttg  caatcatcc  300
tgaagagaa  acactgacc  tggaagtga  tggtcaggt  aagggagac  tggccttcc  360
caacttcca  aacaacctg  agcagactc  actccactt  gctgtgatc  ccaaccagc  420
aggaattgc  gaggcactt  tgaaagctg  ctgtgatcc  gagctccga  actttcgag  480
aaatacccc  ctccatctt  cctgtgagc  gggctgcct  gccagtgta  cagtcttga  540
tcagacctg  acgccccag  atctccact  cgtcctgca  gccaccaac  acaacggcc  600
cacgtgtct  cacttagcc  ctatccatg  ctacctggg  atcgtggag  acttggtga  660
tttgggtgc  gatgtcaac  ctcaggagc  ctgtaatgg  cggacagcc  tccaccttg  720
agtggacct  cagaatcct  acctggtct  gctcctgtt  aagtgtggg  ctgatgtca  780
cagagtaac  taccagggc  actccccct  ccagcttac  tggggccgc  caagtaccc  840
gatacagca  cagctgggc  agctgaccc  ggaaaatct  cagacgctg  ccgagagtg  900
ggatgagga  agctatgac  cggagtcag  attcacgga  gatgagttg  cctacgatg  960
ctgtgtgtt  ggaggccag  gtctgacgt  ataagagga  agtggccaa  ggaacgtgg  1020
cttgtatat  tgtacaaat  gagttttat  tttctaaaa  aaaaaaaaa  aaagaaaaa  1080
aaaaaaaat  agaaaggat  cttagcacc  cagcacaca  cgcctagcc  cgagcattc  1140
attgtggtg  ttcagctgt  gttcttctc  aatttgggg  aacagatca  tgaaattca  1200
aggaaatgt  tcctaaggt  catgtttgt  ggatttttt  ttttttttt  aggtgattt  1260
ccagaatct  ataaaagga  cacatttaa  ttatgtgct  ttggttgaa  cgccataga  1320
gtagctgac  ccagttgcc  tctacgtaa  aaccaggtc  atagtggta  gtgcttaag  1380
accccagct  agatttgta  cactttctt  taaatgttg  atatggatg  attttgttg  1440
taattattt  tggtacttc  aagatgtat  tttattaaa  agattttta  agtatcaaa  1500
aaaaaaaa  1508



<210> 9843
<211> 314
<212> PRT
<213> Rattus norvegicus
<308> CAA45138
<400> 9843

Met Phe Gln Pro Ala Gly His Gly Gln Asp Trp Ala Met Glu Gly Pro 
  1               5                  10                  15
Arg Asp Gly Leu Lys Lys Glu Arg Leu Val Asp Asp Arg His Asp Ser 
             20                  25                  30
Gly Leu Asp Ser Met Lys Asp Glu Asp Tyr Glu Gln Met Val Lys Glu 
         35                  40                  45
Leu Arg Glu Ile Arg Leu Gln Pro Gln Glu Ala Pro Leu Ala Ala Glu 
     50                  55                  60
Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 
 65                  70                  75                  80
Ala Ile Ile His Glu Glu Lys Thr Leu Thr Met Glu Val Ile Gly Gln 
                 85                  90                  95
Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 
             100                105                110
Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Gly Ile Ala Glu 
         115                120                125
Ala Leu Leu Lys Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 
     130                135                140
Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 
 145                150                155                160
Ala Val Leu Thr Gln Thr Cys Thr Pro Gln His Leu His Ser Val Leu 
                 165                170                175
Gln Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 
             180                185                190
His Gly Tyr Leu Gly Ile Val Glu His Leu Val Thr Leu Gly Ala Asp 
         195                200                205
Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 
     210                215                220
Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 
 225                230                235                240
Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 
                 245                250                255
Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 
             260                265                270
Thr Leu Glu Asn Leu Gln Thr Leu Pro Glu Ser Glu Asp Glu Glu Ser 
         275                280                285
Tyr Asp Thr Glu Ser Glu Phe Thr Glu Asp Glu Leu Pro Tyr Asp Asp 
     290                295                300
Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 
 305                310



<210> 9844
<211> 1550
<212> DNA
<213> Homo sapiens
<308> NM_020529
<400> 9844

tgccgccgt  ccgcccgcc  gcgccccag  gaggaagca  cgcgcagcc  gcggcccag  60
gcacccgca  cagcgcccg  agctcgtcc  cgccatgtt  caggcggcc  agcgccccc  120
ggagtgggc  atggagggc  cccgcgacg  gctgaagaa  gagcggcta  tggacgacc  180
ccacgacag  ggcctggac  ccatgaaag  cgaggagta  gagcagatg  tcaaggagc  240
gcaggagat  cgcctcgag  cgcaggagg  gccgcgcgg  tcggagccc  ggaagcagc  300
gctcaccga  gacggggac  cgttcctgc  cttggccat  atccatgaa  aaaaggcac  360
gaccatgga  gtgatccgc  aggtgaagg  agacctggc  ttcctcaac  tccagaaca  420
cctgcagca  actccactc  acttggctg  gatcaccaa  cagccagaa  ttgctgagg  480
acttctggg  gctggctgt  atcctgagc  ccgagactt  cgaggaaat  cccccctac  540
ccttgcctg  gagcagggc  gcctggcca  cgtgggagt  ctgactcag  cctgcacca  600
cccgcacct  cactccatc  tgaaggcta  caactacaa  ggccacacg  gtctacact  660
agcctctat  catggctac  tgggcatcg  ggagctttt  gtgtccttg  gtgctgatg  720
caatgctca  gagccctgt  atggccgga  tgcccttca  ctcgcagtg  acctgcaaa  780
tcctgacct  gtgtcactc  tgttgaagt  tggggctga  gtcaacaga  ttacctacc  840
gggctattc  ccctaccag  tcacctggg  ccgcccaag  acccggata  agcagcagc  900
gggccagct  acactagaa  accttcaga  gctgccaga  agtgaggat  aggagagct  960
tgacacaga  tcagagttc  cggagttca  agaggacga  ctgccctat  atgactgtg  1020
gtttggagg  cagcgtctg  cgttatgag  gcaaagggg  tgaaagaac  tggacttgt  1080
tatttgtac  aaaaaaaag  tttattttt  taaaaaaag  aaaaagaag  aaaaattta  1140
agggtgtac  tatatccac  ctgcacact  cctagccca  aacgtctta  tgtggtagg  1200
tcagccctc  ttttgttgc  tttgtgaac  ttttgtagg  gacgagaaa  atcattgaa  1260
ttctgagaa  acttctttt  aacctcacc  ttgtggggt  tttggagaa  gttatcaaa  1320
atttcatgg  aggaccaca  tttatattt  ttgtgcttc  agtgactga  cccagtggt  1380
tcctgtgac  tgtaacagc  aggagtgtt  agcgttcag  gatgtgggg  gaaaagtta  1440
tacctgtca  ggtttgtgt  accctcctg  aaatggtgt  cataatgta  tgttggtaa  1500
tattttggt  cttttatga  gtatattta  taaagagat  tttacaaatg  1550



<210> 9845
<211> 317
<212> PRT
<213> Homo sapiens
<308> P25963
<400> 9845

Met Phe Gln Ala Ala Glu Arg Pro Gln Glu Trp Ala Met Glu Gly Pro 
  1               5                  10                  15
Arg Asp Gly Leu Lys Lys Glu Arg Leu Leu Asp Asp Arg His Asp Ser 
             20                  25                  30
Gly Leu Asp Ser Met Lys Asp Glu Glu Tyr Glu Gln Met Val Lys Glu 
         35                  40                  45
Leu Gln Glu Ile Arg Leu Glu Pro Gln Glu Val Pro Arg Gly Ser Glu 
     50                  55                  60
Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 
 65                  70                  75                  80
Ala Ile Ile His Glu Glu Lys Ala Leu Thr Met Glu Val Ile Arg Gln 
                 85                  90                  95
Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 
             100                105                110
Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Glu Ile Ala Glu 
         115                120                125
Ala Leu Leu Gly Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 
     130                135                140
Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 
 145                150                155                160
Gly Val Leu Thr Gln Ser Cys Thr Thr Pro His Leu His Ser Ile Leu 
                 165                170                175
Lys Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 
             180                185                190
His Gly Tyr Leu Gly Ile Val Glu Leu Leu Val Ser Leu Gly Ala Asp 
         195                200                205
Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 
     210                215                220
Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 
 225                230                235                240
Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 
                 245                250                255
Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 
             260                265                270
Thr Leu Glu Asn Leu Gln Met Leu Pro Glu Ser Glu Asp Glu Glu Ser 
         275                280                285
Tyr Asp Thr Glu Ser Glu Phe Thr Glu Phe Thr Glu Asp Glu Leu Pro 
     290                295                300
Tyr Asp Asp Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 
 305                310                315



<210> 9846
<211> 1508
<212> DNA
<213> Rattus norvegicus
<308> X63594
<400> 9846

cccaactgc  agcagcctg  accctgcac  cgctcagct  cgcacagcc  tgtttcagc  60
agctgggca  ggccaggac  gggccatgg  gggcccgcg  gacggcctc  agaaggagc  120
gttggtgga  gaccgccac  acagcggct  ggactccat  aaggacgag  attacgagc  180
gatggtgaa  gagctgcgg  agatccgcc  gcagccgca  gaggcgcct  tggctgccg  240
gccctggaa  caacagctc  cggaggacg  agactcgtt  ctgcacttg  caatcatcc  300
tgaagagaa  acactgacc  tggaagtga  tggtcaggt  aagggagac  tggccttcc  360
caacttcca  aacaacctg  agcagactc  actccactt  gctgtgatc  ccaaccagc  420
aggaattgc  gaggcactt  tgaaagctg  ctgtgatcc  gagctccga  actttcgag  480
aaatacccc  ctccatctt  cctgtgagc  gggctgcct  gccagtgta  cagtcttga  540
tcagacctg  acgccccag  atctccact  cgtcctgca  gccaccaac  acaacggcc  600
cacgtgtct  cacttagcc  ctatccatg  ctacctggg  atcgtggag  acttggtga  660
tttgggtgc  gatgtcaac  ctcaggagc  ctgtaatgg  cggacagcc  tccaccttg  720
agtggacct  cagaatcct  acctggtct  gctcctgtt  aagtgtggg  ctgatgtca  780
cagagtaac  taccagggc  actccccct  ccagcttac  tggggccgc  caagtaccc  840
gatacagca  cagctgggc  agctgaccc  ggaaaatct  cagacgctg  ccgagagtg  900
ggatgagga  agctatgac  cggagtcag  attcacgga  gatgagttg  cctacgatg  960
ctgtgtgtt  ggaggccag  gtctgacgt  ataagagga  agtggccaa  ggaacgtgg  1020
cttgtatat  tgtacaaat  gagttttat  tttctaaaa  aaaaaaaaa  aaagaaaaa  1080
aaaaaaaat  agaaaggat  cttagcacc  cagcacaca  cgcctagcc  cgagcattc  1140
attgtggtg  ttcagctgt  gttcttctc  aatttgggg  aacagatca  tgaaattca  1200
aggaaatgt  tcctaaggt  catgtttgt  ggatttttt  ttttttttt  aggtgattt  1260
ccagaatct  ataaaagga  cacatttaa  ttatgtgct  ttggttgaa  cgccataga  1320
gtagctgac  ccagttgcc  tctacgtaa  aaccaggtc  atagtggta  gtgcttaag  1380
accccagct  agatttgta  cactttctt  taaatgttg  atatggatg  attttgttg  1440
taattattt  tggtacttc  aagatgtat  tttattaaa  agattttta  agtatcaaa  1500
aaaaaaaa  1508



<210> 9847
<211> 314
<212> PRT
<213> Rattus norvegicus
<308> CAA45138
<400> 9847

Met Phe Gln Pro Ala Gly His Gly Gln Asp Trp Ala Met Glu Gly Pro 
  1               5                  10                  15
Arg Asp Gly Leu Lys Lys Glu Arg Leu Val Asp Asp Arg His Asp Ser 
             20                  25                  30
Gly Leu Asp Ser Met Lys Asp Glu Asp Tyr Glu Gln Met Val Lys Glu 
         35                  40                  45
Leu Arg Glu Ile Arg Leu Gln Pro Gln Glu Ala Pro Leu Ala Ala Glu 
     50                  55                  60
Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 
 65                  70                  75                  80
Ala Ile Ile His Glu Glu Lys Thr Leu Thr Met Glu Val Ile Gly Gln 
                 85                  90                  95
Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 
             100                105                110
Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Gly Ile Ala Glu 
         115                120                125
Ala Leu Leu Lys Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 
     130                135                140
Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 
 145                150                155                160
Ala Val Leu Thr Gln Thr Cys Thr Pro Gln His Leu His Ser Val Leu 
                 165                170                175
Gln Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 
             180                185                190
His Gly Tyr Leu Gly Ile Val Glu His Leu Val Thr Leu Gly Ala Asp 
         195                200                205
Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 
     210                215                220
Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 
 225                230                235                240
Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 
                 245                250                255
Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 
             260                265                270
Thr Leu Glu Asn Leu Gln Thr Leu Pro Glu Ser Glu Asp Glu Glu Ser 
         275                280                285
Tyr Asp Thr Glu Ser Glu Phe Thr Glu Asp Glu Leu Pro Tyr Asp Asp 
     290                295                300
Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 
 305                310



<210> 9848
<211> 1550
<212> DNA
<213> Homo sapiens
<308> NM_020529
<400> 9848

tgccgccgt  ccgcccgcc  gcgccccag  gaggaagca  cgcgcagcc  gcggcccag  60
gcacccgca  cagcgcccg  agctcgtcc  cgccatgtt  caggcggcc  agcgccccc  120
ggagtgggc  atggagggc  cccgcgacg  gctgaagaa  gagcggcta  tggacgacc  180
ccacgacag  ggcctggac  ccatgaaag  cgaggagta  gagcagatg  tcaaggagc  240
gcaggagat  cgcctcgag  cgcaggagg  gccgcgcgg  tcggagccc  ggaagcagc  300
gctcaccga  gacggggac  cgttcctgc  cttggccat  atccatgaa  aaaaggcac  360
gaccatgga  gtgatccgc  aggtgaagg  agacctggc  ttcctcaac  tccagaaca  420
cctgcagca  actccactc  acttggctg  gatcaccaa  cagccagaa  ttgctgagg  480
acttctggg  gctggctgt  atcctgagc  ccgagactt  cgaggaaat  cccccctac  540
ccttgcctg  gagcagggc  gcctggcca  cgtgggagt  ctgactcag  cctgcacca  600
cccgcacct  cactccatc  tgaaggcta  caactacaa  ggccacacg  gtctacact  660
agcctctat  catggctac  tgggcatcg  ggagctttt  gtgtccttg  gtgctgatg  720
caatgctca  gagccctgt  atggccgga  tgcccttca  ctcgcagtg  acctgcaaa  780
tcctgacct  gtgtcactc  tgttgaagt  tggggctga  gtcaacaga  ttacctacc  840
gggctattc  ccctaccag  tcacctggg  ccgcccaag  acccggata  agcagcagc  900
gggccagct  acactagaa  accttcaga  gctgccaga  agtgaggat  aggagagct  960
tgacacaga  tcagagttc  cggagttca  agaggacga  ctgccctat  atgactgtg  1020
gtttggagg  cagcgtctg  cgttatgag  gcaaagggg  tgaaagaac  tggacttgt  1080
tatttgtac  aaaaaaaag  tttattttt  taaaaaaag  aaaaagaag  aaaaattta  1140
agggtgtac  tatatccac  ctgcacact  cctagccca  aacgtctta  tgtggtagg  1200
tcagccctc  ttttgttgc  tttgtgaac  ttttgtagg  gacgagaaa  atcattgaa  1260
ttctgagaa  acttctttt  aacctcacc  ttgtggggt  tttggagaa  gttatcaaa  1320
atttcatgg  aggaccaca  tttatattt  ttgtgcttc  agtgactga  cccagtggt  1380
tcctgtgac  tgtaacagc  aggagtgtt  agcgttcag  gatgtgggg  gaaaagtta  1440
tacctgtca  ggtttgtgt  accctcctg  aaatggtgt  cataatgta  tgttggtaa  1500
tattttggt  cttttatga  gtatattta  taaagagat  tttacaaatg  1550



<210> 9849
<211> 317
<212> PRT
<213> Homo sapiens
<308> P25963
<400> 9849

Met Phe Gln Ala Ala Glu Arg Pro Gln Glu Trp Ala Met Glu Gly Pro 
  1               5                  10                  15
Arg Asp Gly Leu Lys Lys Glu Arg Leu Leu Asp Asp Arg His Asp Ser 
             20                  25                  30
Gly Leu Asp Ser Met Lys Asp Glu Glu Tyr Glu Gln Met Val Lys Glu 
         35                  40                  45
Leu Gln Glu Ile Arg Leu Glu Pro Gln Glu Val Pro Arg Gly Ser Glu 
     50                  55                  60
Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 
 65                  70                  75                  80
Ala Ile Ile His Glu Glu Lys Ala Leu Thr Met Glu Val Ile Arg Gln 
                 85                  90                  95
Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 
             100                105                110
Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Glu Ile Ala Glu 
         115                120                125
Ala Leu Leu Gly Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 
     130                135                140
Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 
 145                150                155                160
Gly Val Leu Thr Gln Ser Cys Thr Thr Pro His Leu His Ser Ile Leu 
                 165                170                175
Lys Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 
             180                185                190
His Gly Tyr Leu Gly Ile Val Glu Leu Leu Val Ser Leu Gly Ala Asp 
         195                200                205
Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 
     210                215                220
Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 
 225                230                235                240
Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 
                 245                250                255
Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 
             260                265                270
Thr Leu Glu Asn Leu Gln Met Leu Pro Glu Ser Glu Asp Glu Glu Ser 
         275                280                285
Tyr Asp Thr Glu Ser Glu Phe Thr Glu Phe Thr Glu Asp Glu Leu Pro 
     290                295                300
Tyr Asp Asp Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 
 305                310                315



<210> 9850
<211> 1508
<212> DNA
<213> Rattus norvegicus
<308> X63594
<400> 9850

cccaactgc  agcagcctg  accctgcac  cgctcagct  cgcacagcc  tgtttcagc  60
agctgggca  ggccaggac  gggccatgg  gggcccgcg  gacggcctc  agaaggagc  120
gttggtgga  gaccgccac  acagcggct  ggactccat  aaggacgag  attacgagc  180
gatggtgaa  gagctgcgg  agatccgcc  gcagccgca  gaggcgcct  tggctgccg  240
gccctggaa  caacagctc  cggaggacg  agactcgtt  ctgcacttg  caatcatcc  300
tgaagagaa  acactgacc  tggaagtga  tggtcaggt  aagggagac  tggccttcc  360
caacttcca  aacaacctg  agcagactc  actccactt  gctgtgatc  ccaaccagc  420
aggaattgc  gaggcactt  tgaaagctg  ctgtgatcc  gagctccga  actttcgag  480
aaatacccc  ctccatctt  cctgtgagc  gggctgcct  gccagtgta  cagtcttga  540
tcagacctg  acgccccag  atctccact  cgtcctgca  gccaccaac  acaacggcc  600
cacgtgtct  cacttagcc  ctatccatg  ctacctggg  atcgtggag  acttggtga  660
tttgggtgc  gatgtcaac  ctcaggagc  ctgtaatgg  cggacagcc  tccaccttg  720
agtggacct  cagaatcct  acctggtct  gctcctgtt  aagtgtggg  ctgatgtca  780
cagagtaac  taccagggc  actccccct  ccagcttac  tggggccgc  caagtaccc  840
gatacagca  cagctgggc  agctgaccc  ggaaaatct  cagacgctg  ccgagagtg  900
ggatgagga  agctatgac  cggagtcag  attcacgga  gatgagttg  cctacgatg  960
ctgtgtgtt  ggaggccag  gtctgacgt  ataagagga  agtggccaa  ggaacgtgg  1020
cttgtatat  tgtacaaat  gagttttat  tttctaaaa  aaaaaaaaa  aaagaaaaa  1080
aaaaaaaat  agaaaggat  cttagcacc  cagcacaca  cgcctagcc  cgagcattc  1140
attgtggtg  ttcagctgt  gttcttctc  aatttgggg  aacagatca  tgaaattca  1200
aggaaatgt  tcctaaggt  catgtttgt  ggatttttt  ttttttttt  aggtgattt  1260
ccagaatct  ataaaagga  cacatttaa  ttatgtgct  ttggttgaa  cgccataga  1320
gtagctgac  ccagttgcc  tctacgtaa  aaccaggtc  atagtggta  gtgcttaag  1380
accccagct  agatttgta  cactttctt  taaatgttg  atatggatg  attttgttg  1440
taattattt  tggtacttc  aagatgtat  tttattaaa  agattttta  agtatcaaa  1500
aaaaaaaa  1508



<210> 9851
<211> 314
<212> PRT
<213> Rattus norvegicus
<308> CAA45138
<400> 9851

Met Phe Gln Pro Ala Gly His Gly Gln Asp Trp Ala Met Glu Gly Pro 
  1               5                  10                  15
Arg Asp Gly Leu Lys Lys Glu Arg Leu Val Asp Asp Arg His Asp Ser 
             20                  25                  30
Gly Leu Asp Ser Met Lys Asp Glu Asp Tyr Glu Gln Met Val Lys Glu 
         35                  40                  45
Leu Arg Glu Ile Arg Leu Gln Pro Gln Glu Ala Pro Leu Ala Ala Glu 
     50                  55                  60
Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 
 65                  70                  75                  80
Ala Ile Ile His Glu Glu Lys Thr Leu Thr Met Glu Val Ile Gly Gln 
                 85                  90                  95
Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 
             100                105                110
Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Gly Ile Ala Glu 
         115                120                125
Ala Leu Leu Lys Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 
     130                135                140
Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 
 145                150                155                160
Ala Val Leu Thr Gln Thr Cys Thr Pro Gln His Leu His Ser Val Leu 
                 165                170                175
Gln Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 
             180                185                190
His Gly Tyr Leu Gly Ile Val Glu His Leu Val Thr Leu Gly Ala Asp 
         195                200                205
Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 
     210                215                220
Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 
 225                230                235                240
Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 
                 245                250                255
Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 
             260                265                270
Thr Leu Glu Asn Leu Gln Thr Leu Pro Glu Ser Glu Asp Glu Glu Ser 
         275                280                285
Tyr Asp Thr Glu Ser Glu Phe Thr Glu Asp Glu Leu Pro Tyr Asp Asp 
     290                295                300
Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 
 305                310



<210> 9852
<211> 1550
<212> DNA
<213> Homo sapiens
<308> NM_020529
<400> 9852

tgccgccgt  ccgcccgcc  gcgccccag  gaggaagca  cgcgcagcc  gcggcccag  60
gcacccgca  cagcgcccg  agctcgtcc  cgccatgtt  caggcggcc  agcgccccc  120
ggagtgggc  atggagggc  cccgcgacg  gctgaagaa  gagcggcta  tggacgacc  180
ccacgacag  ggcctggac  ccatgaaag  cgaggagta  gagcagatg  tcaaggagc  240
gcaggagat  cgcctcgag  cgcaggagg  gccgcgcgg  tcggagccc  ggaagcagc  300
gctcaccga  gacggggac  cgttcctgc  cttggccat  atccatgaa  aaaaggcac  360
gaccatgga  gtgatccgc  aggtgaagg  agacctggc  ttcctcaac  tccagaaca  420
cctgcagca  actccactc  acttggctg  gatcaccaa  cagccagaa  ttgctgagg  480
acttctggg  gctggctgt  atcctgagc  ccgagactt  cgaggaaat  cccccctac  540
ccttgcctg  gagcagggc  gcctggcca  cgtgggagt  ctgactcag  cctgcacca  600
cccgcacct  cactccatc  tgaaggcta  caactacaa  ggccacacg  gtctacact  660
agcctctat  catggctac  tgggcatcg  ggagctttt  gtgtccttg  gtgctgatg  720
caatgctca  gagccctgt  atggccgga  tgcccttca  ctcgcagtg  acctgcaaa  780
tcctgacct  gtgtcactc  tgttgaagt  tggggctga  gtcaacaga  ttacctacc  840
gggctattc  ccctaccag  tcacctggg  ccgcccaag  acccggata  agcagcagc  900
gggccagct  acactagaa  accttcaga  gctgccaga  agtgaggat  aggagagct  960
tgacacaga  tcagagttc  cggagttca  agaggacga  ctgccctat  atgactgtg  1020
gtttggagg  cagcgtctg  cgttatgag  gcaaagggg  tgaaagaac  tggacttgt  1080
tatttgtac  aaaaaaaag  tttattttt  taaaaaaag  aaaaagaag  aaaaattta  1140
agggtgtac  tatatccac  ctgcacact  cctagccca  aacgtctta  tgtggtagg  1200
tcagccctc  ttttgttgc  tttgtgaac  ttttgtagg  gacgagaaa  atcattgaa  1260
ttctgagaa  acttctttt  aacctcacc  ttgtggggt  tttggagaa  gttatcaaa  1320
atttcatgg  aggaccaca  tttatattt  ttgtgcttc  agtgactga  cccagtggt  1380
tcctgtgac  tgtaacagc  aggagtgtt  agcgttcag  gatgtgggg  gaaaagtta  1440
tacctgtca  ggtttgtgt  accctcctg  aaatggtgt  cataatgta  tgttggtaa  1500
tattttggt  cttttatga  gtatattta  taaagagat  tttacaaatg  1550



<210> 9853
<211> 317
<212> PRT
<213> Homo sapiens
<308> P25963
<400> 9853

Met Phe Gln Ala Ala Glu Arg Pro Gln Glu Trp Ala Met Glu Gly Pro 
  1               5                  10                  15
Arg Asp Gly Leu Lys Lys Glu Arg Leu Leu Asp Asp Arg His Asp Ser 
             20                  25                  30
Gly Leu Asp Ser Met Lys Asp Glu Glu Tyr Glu Gln Met Val Lys Glu 
         35                  40                  45
Leu Gln Glu Ile Arg Leu Glu Pro Gln Glu Val Pro Arg Gly Ser Glu 
     50                  55                  60
Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 
 65                  70                  75                  80
Ala Ile Ile His Glu Glu Lys Ala Leu Thr Met Glu Val Ile Arg Gln 
                 85                  90                  95
Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 
             100                105                110
Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Glu Ile Ala Glu 
         115                120                125
Ala Leu Leu Gly Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 
     130                135                140
Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 
 145                150                155                160
Gly Val Leu Thr Gln Ser Cys Thr Thr Pro His Leu His Ser Ile Leu 
                 165                170                175
Lys Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 
             180                185                190
His Gly Tyr Leu Gly Ile Val Glu Leu Leu Val Ser Leu Gly Ala Asp 
         195                200                205
Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 
     210                215                220
Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 
 225                230                235                240
Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 
                 245                250                255
Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 
             260                265                270
Thr Leu Glu Asn Leu Gln Met Leu Pro Glu Ser Glu Asp Glu Glu Ser 
         275                280                285
Tyr Asp Thr Glu Ser Glu Phe Thr Glu Phe Thr Glu Asp Glu Leu Pro 
     290                295                300
Tyr Asp Asp Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 
 305                310                315



<210> 9854
<211> 1508
<212> DNA
<213> Rattus norvegicus
<308> X63594
<400> 9854

cccaactgc  agcagcctg  accctgcac  cgctcagct  cgcacagcc  tgtttcagc  60
agctgggca  ggccaggac  gggccatgg  gggcccgcg  gacggcctc  agaaggagc  120
gttggtgga  gaccgccac  acagcggct  ggactccat  aaggacgag  attacgagc  180
gatggtgaa  gagctgcgg  agatccgcc  gcagccgca  gaggcgcct  tggctgccg  240
gccctggaa  caacagctc  cggaggacg  agactcgtt  ctgcacttg  caatcatcc  300
tgaagagaa  acactgacc  tggaagtga  tggtcaggt  aagggagac  tggccttcc  360
caacttcca  aacaacctg  agcagactc  actccactt  gctgtgatc  ccaaccagc  420
aggaattgc  gaggcactt  tgaaagctg  ctgtgatcc  gagctccga  actttcgag  480
aaatacccc  ctccatctt  cctgtgagc  gggctgcct  gccagtgta  cagtcttga  540
tcagacctg  acgccccag  atctccact  cgtcctgca  gccaccaac  acaacggcc  600
cacgtgtct  cacttagcc  ctatccatg  ctacctggg  atcgtggag  acttggtga  660
tttgggtgc  gatgtcaac  ctcaggagc  ctgtaatgg  cggacagcc  tccaccttg  720
agtggacct  cagaatcct  acctggtct  gctcctgtt  aagtgtggg  ctgatgtca  780
cagagtaac  taccagggc  actccccct  ccagcttac  tggggccgc  caagtaccc  840
gatacagca  cagctgggc  agctgaccc  ggaaaatct  cagacgctg  ccgagagtg  900
ggatgagga  agctatgac  cggagtcag  attcacgga  gatgagttg  cctacgatg  960
ctgtgtgtt  ggaggccag  gtctgacgt  ataagagga  agtggccaa  ggaacgtgg  1020
cttgtatat  tgtacaaat  gagttttat  tttctaaaa  aaaaaaaaa  aaagaaaaa  1080
aaaaaaaat  agaaaggat  cttagcacc  cagcacaca  cgcctagcc  cgagcattc  1140
attgtggtg  ttcagctgt  gttcttctc  aatttgggg  aacagatca  tgaaattca  1200
aggaaatgt  tcctaaggt  catgtttgt  ggatttttt  ttttttttt  aggtgattt  1260
ccagaatct  ataaaagga  cacatttaa  ttatgtgct  ttggttgaa  cgccataga  1320
gtagctgac  ccagttgcc  tctacgtaa  aaccaggtc  atagtggta  gtgcttaag  1380
accccagct  agatttgta  cactttctt  taaatgttg  atatggatg  attttgttg  1440
taattattt  tggtacttc  aagatgtat  tttattaaa  agattttta  agtatcaaa  1500
aaaaaaaa  1508



<210> 9855
<211> 314
<212> PRT
<213> Rattus norvegicus
<308> CAA45138
<400> 9855

Met Phe Gln Pro Ala Gly His Gly Gln Asp Trp Ala Met Glu Gly Pro 
  1               5                  10                  15
Arg Asp Gly Leu Lys Lys Glu Arg Leu Val Asp Asp Arg His Asp Ser 
             20                  25                  30
Gly Leu Asp Ser Met Lys Asp Glu Asp Tyr Glu Gln Met Val Lys Glu 
         35                  40                  45
Leu Arg Glu Ile Arg Leu Gln Pro Gln Glu Ala Pro Leu Ala Ala Glu 
     50                  55                  60
Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 
 65                  70                  75                  80
Ala Ile Ile His Glu Glu Lys Thr Leu Thr Met Glu Val Ile Gly Gln 
                 85                  90                  95
Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 
             100                105                110
Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Gly Ile Ala Glu 
         115                120                125
Ala Leu Leu Lys Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 
     130                135                140
Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 
 145                150                155                160
Ala Val Leu Thr Gln Thr Cys Thr Pro Gln His Leu His Ser Val Leu 
                 165                170                175
Gln Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 
             180                185                190
His Gly Tyr Leu Gly Ile Val Glu His Leu Val Thr Leu Gly Ala Asp 
         195                200                205
Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 
     210                215                220
Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 
 225                230                235                240
Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 
                 245                250                255
Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 
             260                265                270
Thr Leu Glu Asn Leu Gln Thr Leu Pro Glu Ser Glu Asp Glu Glu Ser 
         275                280                285
Tyr Asp Thr Glu Ser Glu Phe Thr Glu Asp Glu Leu Pro Tyr Asp Asp 
     290                295                300
Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 
 305                310



<210> 9856
<211> 1550
<212> DNA
<213> Homo sapiens
<308> NM_020529
<400> 9856

tgccgccgt  ccgcccgcc  gcgccccag  gaggaagca  cgcgcagcc  gcggcccag  60
gcacccgca  cagcgcccg  agctcgtcc  cgccatgtt  caggcggcc  agcgccccc  120
ggagtgggc  atggagggc  cccgcgacg  gctgaagaa  gagcggcta  tggacgacc  180
ccacgacag  ggcctggac  ccatgaaag  cgaggagta  gagcagatg  tcaaggagc  240
gcaggagat  cgcctcgag  cgcaggagg  gccgcgcgg  tcggagccc  ggaagcagc  300
gctcaccga  gacggggac  cgttcctgc  cttggccat  atccatgaa  aaaaggcac  360
gaccatgga  gtgatccgc  aggtgaagg  agacctggc  ttcctcaac  tccagaaca  420
cctgcagca  actccactc  acttggctg  gatcaccaa  cagccagaa  ttgctgagg  480
acttctggg  gctggctgt  atcctgagc  ccgagactt  cgaggaaat  cccccctac  540
ccttgcctg  gagcagggc  gcctggcca  cgtgggagt  ctgactcag  cctgcacca  600
cccgcacct  cactccatc  tgaaggcta  caactacaa  ggccacacg  gtctacact  660
agcctctat  catggctac  tgggcatcg  ggagctttt  gtgtccttg  gtgctgatg  720
caatgctca  gagccctgt  atggccgga  tgcccttca  ctcgcagtg  acctgcaaa  780
tcctgacct  gtgtcactc  tgttgaagt  tggggctga  gtcaacaga  ttacctacc  840
gggctattc  ccctaccag  tcacctggg  ccgcccaag  acccggata  agcagcagc  900
gggccagct  acactagaa  accttcaga  gctgccaga  agtgaggat  aggagagct  960
tgacacaga  tcagagttc  cggagttca  agaggacga  ctgccctat  atgactgtg  1020
gtttggagg  cagcgtctg  cgttatgag  gcaaagggg  tgaaagaac  tggacttgt  1080
tatttgtac  aaaaaaaag  tttattttt  taaaaaaag  aaaaagaag  aaaaattta  1140
agggtgtac  tatatccac  ctgcacact  cctagccca  aacgtctta  tgtggtagg  1200
tcagccctc  ttttgttgc  tttgtgaac  ttttgtagg  gacgagaaa  atcattgaa  1260
ttctgagaa  acttctttt  aacctcacc  ttgtggggt  tttggagaa  gttatcaaa  1320
atttcatgg  aggaccaca  tttatattt  ttgtgcttc  agtgactga  cccagtggt  1380
tcctgtgac  tgtaacagc  aggagtgtt  agcgttcag  gatgtgggg  gaaaagtta  1440
tacctgtca  ggtttgtgt  accctcctg  aaatggtgt  cataatgta  tgttggtaa  1500
tattttggt  cttttatga  gtatattta  taaagagat  tttacaaatg  1550



<210> 9857
<211> 317
<212> PRT
<213> Homo sapiens
<308> P25963
<400> 9857

Met Phe Gln Ala Ala Glu Arg Pro Gln Glu Trp Ala Met Glu Gly Pro 
  1               5                  10                  15
Arg Asp Gly Leu Lys Lys Glu Arg Leu Leu Asp Asp Arg His Asp Ser 
             20                  25                  30
Gly Leu Asp Ser Met Lys Asp Glu Glu Tyr Glu Gln Met Val Lys Glu 
         35                  40                  45
Leu Gln Glu Ile Arg Leu Glu Pro Gln Glu Val Pro Arg Gly Ser Glu 
     50                  55                  60
Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 
 65                  70                  75                  80
Ala Ile Ile His Glu Glu Lys Ala Leu Thr Met Glu Val Ile Arg Gln 
                 85                  90                  95
Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 
             100                105                110
Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Glu Ile Ala Glu 
         115                120                125
Ala Leu Leu Gly Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 
     130                135                140
Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 
 145                150                155                160
Gly Val Leu Thr Gln Ser Cys Thr Thr Pro His Leu His Ser Ile Leu 
                 165                170                175
Lys Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 
             180                185                190
His Gly Tyr Leu Gly Ile Val Glu Leu Leu Val Ser Leu Gly Ala Asp 
         195                200                205
Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 
     210                215                220
Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 
 225                230                235                240
Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 
                 245                250                255
Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 
             260                265                270
Thr Leu Glu Asn Leu Gln Met Leu Pro Glu Ser Glu Asp Glu Glu Ser 
         275                280                285
Tyr Asp Thr Glu Ser Glu Phe Thr Glu Phe Thr Glu Asp Glu Leu Pro 
     290                295                300
Tyr Asp Asp Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 
 305                310                315



<210> 9858
<211> 2446
<212> DNA
<213> Rattus norvegicus
<308> X63854
<400> 9858

cgtcgctgc  cacccagaa  acccagttt  ggaggaagc  gatttcaga  gctctcctg  60
ggtgccgct  cgcagccgc  gaccccacc  tggcgctgt  ccacccgag  ccctgggcc  120
ctctgctgc  ggtggacct  gctttactt  ggttgctac  aagctctct  ggaactctg  180
ttcccccgg  gctgccagg  ctatggctg  agggcaccc  gcgacttgg  gtgctgtgg  240
gactgctaa  agtgggagg  ctgctgaga  tcgtgggga  ctttctgcc  ttgctctgc  300
tgactaacc  cctgttttt  tcgctgaga  ccctggtgg  aagcaccat  agcacctca  360
tagtcagag  ggcttctgc  tcttggggc  ggctgcttg  tgactatgg  gccgtggcg  420
tgagccttg  cgtgtgggc  gtgctgagc  ccgctggag  acaggagaa  gaaccaggc  480
aggagaata  cagagcact  atgatacgg  tgctgaggc  gtccaagcc  gatctgcct  540
tcctcatcg  tgccttcat  tttcttgcg  tggctgtgt  gtgggagat  ttcatccct  600
attattcgg  tcgtgtgat  gacatcctg  gaggtgatt  tgacccaga  gcctttgcg  660
gcgccatct  tttcatgtg  ttattctct  ttgggagct  cctctctgc  ggctgccga  720
gaggctcct  cctctttgc  gagtccagg  tcaacctgc  catacgaga  cagcttttc  780
catctttgt  gcgccaaga  cttgcattc  tccaggaga  caagacagg  gagctgaac  840
cacggctga  ctcggacac  tccctgatg  gccagtggc  ctctttaaa  gccaatatc  900
tgctgcgga  cctggtgaa  gtggtgggg  tgtactact  catgctcca  gtctccccg  960
gacttacct  cctctccct  ctggacctg  ccctcacaa  agcagccga  aaggtgtac  1020
acccccgcc  tcaggctgt  ctaaaggag  tccaggatg  agtggcgaa  gcagggcag  1080
tggtgcgtg  ggccgtagg  ggcctgcag  ccgtgagaa  ctttggggc  gaggagcag  1140
aagtcagac  ctacaagga  gccctggag  gatgtcgac  gctgtggtg  cgccgagac  1200
tggaaaaaa  cttgtattt  gttatacag  gggtaatgg  cttgggcat  caggtgctg  1260
ttctgaacg  cggtgtgca  cagatcctg  ctggggagg  cacccgggg  ggcctgctc  1320
ccttcctgc  gtatcagga  gaagtgggg  accatgtcc  gaacctggt  tacatgtat  1380
gggatatgc  gagcaacgt  ggtgctgcg  aaaaggttt  ttcctactt  gaccgaagg  1440
caaatctgc  gaatcctgg  accctggcc  ctcccaggc  ggaggggcg  gtggaattt  1500
aagatgtct  cttctcgta  cccagtcgc  ccgagaagc  tgtgctcca  ggcctgacg  1560
tcaccctgc  tcctggaaa  gtgacggct  tggtgggac  caatgggtc  gggaagagc  1620
ccgtggccg  cctgctgca  aacctgtac  agcccaccg  gggccagct  ctgctggat  1680
gcgagcccc  ggtccagta  gatcatcac  acctgcacc  ccaggtggt  ctggtgggg  1740
aggagcctg  gctgttctc  ggttctgtc  aggacaata  tgcctatgg  ctgagggac  1800
gtgaggacg  tcaagtgat  gctgctgcc  aggcggcct  tgcagacga  ttcataggg  1860
aaatgacga  tggaataaa  acagaaatc  gggagaaag  gagccagtt  gctgtggga  1920
agaaacaac  tctggccat  gcccgggcc  ttgtgcgga  cccgcgggt  ctcatcctg  1980
atgaggcta  cagtgccct  gacgccgag  gcgagcagg  ccttcagac  tggagatcg  2040
aggaggaca  gacgatgct  gtcattgct  accggctgc  cacggttca  aatgctgac  2100
aagttctgg  gctcaagca  gggcagctg  tggagcacg  ccagctcag  gatgagcag  2160
atgtctacg  tcacttggt  cagcagcgg  tggaggcgt  aggcctcca  acactgagc  2220
ctctcagga  tgtggccag  atctgaccc  cagggactg  gctggaggc  agcgtcagg  2280
taaagattg  gaccctttg  actttgttt  ttttggtgg  cttggtggg  gagggccag  2340
ggatgggat  gttgctggg  ggggtgggt  gtttaaaca  tattttttt  taaatataa  2400
aataataaa  atatatata  tactttaaa  aaaaaaaaa  aaaaaa  2446



<210> 9859
<211> 703
<212> PRT
<213> Rattus norvegicus
<308> P36372
<400> 9859

Met Ala Leu Ser His Pro Arg Pro Trp Ala Ser Leu Leu Leu Val Asp 
  1               5                  10                  15
Leu Ala Leu Leu Gly Leu Leu Gln Ser Ser Leu Gly Thr Leu Leu Pro 
             20                  25                  30
Pro Gly Leu Pro Gly Leu Trp Leu Glu Gly Thr Leu Arg Leu Gly Val 
         35                  40                  45
Leu Trp Gly Leu Leu Lys Val Gly Gly Leu Leu Arg Leu Val Gly Thr 
     50                  55                  60
Phe Leu Pro Leu Leu Cys Leu Thr Asn Pro Leu Phe Phe Ser Leu Arg 
 65                  70                  75                  80
Ala Leu Val Gly Ser Thr Met Ser Thr Ser Val Val Arg Val Ala Ser 
                 85                  90                  95
Ala Ser Trp Gly Trp Leu Leu Ala Asp Tyr Gly Ala Val Ala Leu Ser 
             100                105                110
Leu Ala Val Trp Ala Val Leu Ser Pro Ala Gly Ala Gln Glu Lys Glu 
         115                120                125
Pro Gly Gln Glu Asn Asn Arg Ala Leu Met Ile Arg Leu Leu Arg Leu 
     130                135                140
Ser Lys Pro Asp Leu Pro Phe Leu Ile Val Ala Phe Ile Phe Leu Ala 
 145                150                155                160
Met Ala Val Trp Trp Glu Met Phe Ile Pro His Tyr Ser Gly Arg Val 
                 165                170                175
Ile Asp Ile Leu Gly Gly Asp Phe Asp Pro Asp Ala Phe Ala Ser Ala 
             180                185                190
Ile Phe Phe Met Cys Leu Phe Ser Val Gly Ser Ser Leu Ser Ala Gly 
         195                200                205
Cys Arg Gly Gly Ser Phe Leu Phe Ala Glu Ser Arg Ile Asn Leu Arg 
     210                215                220
Ile Arg Glu Gln Leu Phe Ser Ser Leu Leu Arg Gln Asp Leu Ala Phe 
 225                230                235                240
Phe Gln Glu Thr Lys Thr Gly Glu Leu Asn Ser Arg Leu Ser Ser Asp 
                 245                250                255
Thr Ser Leu Met Ser Gln Trp Leu Ser Leu Asn Ala Asn Ile Leu Leu 
             260                265                270
Arg Ser Leu Val Lys Val Val Gly Leu Tyr Tyr Phe Met Leu Gln Val 
         275                280                285
Ser Pro Arg Leu Thr Phe Leu Ser Leu Leu Asp Leu Pro Leu Thr Ile 
     290                295                300
Ala Ala Glu Lys Val Tyr Asn Pro Arg His Gln Ala Val Leu Lys Glu 
 305                310                315                320
Ile Gln Asp Ala Val Ala Lys Ala Gly Gln Val Val Arg Glu Ala Val 
                 325                330                335
Gly Gly Leu Gln Thr Val Arg Ser Phe Gly Ala Glu Glu Gln Glu Val 
             340                345                350
Arg Arg Tyr Lys Glu Ala Leu Glu Arg Cys Arg Gln Leu Trp Trp Arg 
         355                360                365
Arg Asp Leu Glu Lys Ser Leu Tyr Leu Val Ile Gln Arg Val Met Ala 
     370                375                380
Leu Gly Met Gln Val Leu Ile Leu Asn Val Gly Val Gln Gln Ile Leu 
 385                390                395                400
Ala Gly Glu Val Thr Arg Gly Gly Leu Leu Ser Phe Leu Leu Tyr Gln 
                 405                410                415
Glu Glu Val Gly His His Val Gln Asn Leu Val Tyr Met Tyr Gly Asp 
             420                425                430
Met Leu Ser Asn Val Gly Ala Ala Glu Lys Val Phe Ser Tyr Leu Asp 
         435                440                445
Arg Arg Pro Asn Leu Pro Asn Pro Gly Thr Leu Ala Pro Pro Arg Leu 
     450                455                460
Glu Gly Arg Val Glu Phe Gln Asp Val Ser Phe Ser Tyr Pro Ser Arg 
 465                470                475                480
Pro Glu Lys Pro Val Leu Gln Gly Leu Thr Phe Thr Leu His Pro Gly 
                 485                490                495
Lys Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val 
             500                505                510
Ala Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly Gln Leu Leu 
         515                520                525
Leu Asp Gly Glu Pro Leu Val Gln Tyr Asp His His Tyr Leu His Arg 
     530                535                540
Gln Val Val Leu Val Gly Gln Glu Pro Val Leu Phe Ser Gly Ser Val 
 545                550                555                560
Lys Asp Asn Ile Ala Tyr Gly Leu Arg Asp Cys Glu Asp Ala Gln Val 
                 565                570                575
Met Ala Ala Ala Gln Ala Ala Cys Ala Asp Asp Phe Ile Gly Glu Met 
             580                585                590
Thr Asn Gly Ile Asn Thr Glu Ile Gly Glu Lys Gly Ser Gln Leu Ala 
         595                600                605
Val Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg Ala Leu Val Arg Asn 
     610                615                620
Pro Arg Val Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Ala Glu 
 625                630                635                640
Cys Glu Gln Ala Leu Gln Thr Trp Arg Ser Gln Glu Asp Arg Thr Met 
                 645                650                655
Leu Val Ile Ala His Arg Leu His Thr Val Gln Asn Ala Asp Gln Val 
             660                665                670
Leu Val Leu Lys Gln Gly Gln Leu Val Glu His Asp Gln Leu Arg Asp 
         675                680                685
Glu Gln Asp Val Tyr Ala His Leu Val Gln Gln Arg Leu Glu Ala 
     690                695                700



<210> 9860
<211> 2824
<212> DNA
<213> Homo sapiens
<308> X57522
<400> 9860

gcggccgct  tcgatttcg  tttccccta  atggctgag  ttctcgcca  cgcaggatc  60
gcctgttcc  gggactttc  gagagcccc  ccctcgttc  ctcccccag  cgccagtag  120
ggaggactc  gcggtaccc  gagcttcag  ccccaccgg  gcgcggaga  tcccagacc  180
ggccgggac  gggacggcg  ccgagtgcc  atggctagc  ctaggtgtc  cgctccccg  240
gggtgccgc  gcctccccg  agcttctct  gcatggctg  ggacagtac  gctacttct  300
gccgactgg  tgctgctcc  gaccgcgct  ccccgcata  tctccctgc  ggtgcccac  360
gcgctgcca  tgctccggg  ctgggcggt  ggcctgagc  gctgggccg  gctctggct  420
ggggcctgc  gggtcctca  ggcaacggt  ggctccaag  gcgaaaacg  aggtgccca  480
ggctggctg  ctgctttga  gccattagc  gcggcactg  gcttggccc  gccgggact  540
gccttgttc  gagagctga  ctcatgggg  gcccccggg  ccgcggata  caccaggct  600
ctgcactgg  gaagtcacc  taccgcctt  gttgtcagt  atgcagcgg  actgcccgc  660
gcagccctg  ggcacaaac  cgggagcct  tgggtgccc  gcggtcagg  cggctctgg  720
aaccctgtg  gtcggcttc  aggctgcct  ggctcggag  cgcgccgcc  ctcgctgtt  780
ctggtcctg  tggtcctct  ctctcttgg  gagatggcc  ttccattct  tacgggccg  840
ctcactgac  ggattctac  agatggctc  gccgatacc  tcactcgaa  cttaactct  900
atgtccatt  tcaccatag  cagtgcagt  ctggagttc  tgggtgacg  gatctataa  960
aacaccatg  gccacgtgc  cagccactt  cagggagag  tgtttgggg  tgtcctgcg  1020
caggagacg  agtttttcc  acagaacca  acaggtaac  tcatgtctc  ggtaacaga  1080
gacacgtcc  ccctgagtg  ttctctgag  gagaatctg  gcttatttc  gtggtacct  1140
gtgcgaggc  tatgtctct  ggggatcat  ctctgggga  cagtgtccc  caccatggt  1200
accctgatc  ccctgcctc  gcttttcct  ctgcccaag  aggtgggaa  atggtacca  1260
ttgctggaa  tgcaggtgc  ggaatctct  gcaaagtcc  gccaggtgg  cattgaggc  1320
ctgtcggcc  tgcctacag  tcgaagctt  gccaacgag  agggcgaag  ccagaagtt  1380
agggaaaag  tgcaagaaa  aaagacact  aaccagaag  aggctgtgg  ctatgcagt  1440
aactcctgg  ccactagta  ttcaggtat  ctgctgaaa  tgggaatcc  ctacattgg  1500
gggcagctg  tgaccagtg  ggctgtaag  agtgggaac  ttgtcacat  tgttctcta  1560
cagatgcag  tcacccagg  tgtggaggt  ctgctctcc  tctacccca  agtacagaa  1620
gctgtgggc  cctcagaga  aatatttga  tacctggac  gcacccctc  ctgcccacc  1680
agtggtctg  tgactccct  acacttgga  ggccttgtc  agttccaag  tgtctcctt  1740
gcctaccca  accgcccag  tgtcttagt  ctacagggg  tgacattca  cctacgccc  1800
ggcgaggtg  cggcgctgg  gggacccaa  gggtctggg  agagcacag  ggctgccct  1860
ctgcagaat  tgtaccagc  caccggggg  cagctgctg  tggatggga  gccccttcc  1920
caatatgag  accgctacc  gcacaggca  gtggctgca  tgggacaag  gccacaggt  1980
tttggaaga  gtcttcaag  aaatattgc  tatggcctg  cccagaagc  aactatgga  2040
gaaatcaca  ctgctgcag  aaagtctgg  gcccatagt  tcatctctg  actccctca  2100
ggctatgac  cagaggtag  cgaggctgg  agccagctg  cagggggtc  gcgacaggc  2160
gtggcgttg  cccgagcat  gatccggaa  ccgtgtgta  ttatcctgg  tgatgccac  2220
agtgccctg  atgcaaaca  ccagttaca  gtggagcag  tcctgtacg  aagccctga  2280
cggtactcc  gctcagtgc  tctcatcac  cagcacctc  gcctggtgg  gcaggctga  2340
cacatcctc  ttctggaag  aggcgctat  cgggagggg  gaacccacc  gcagctcat  2400
gagaaaaag  ggtgctact  ggccatggt  caggctcct  cagatgctc  agaatgaaa  2460
ccttctcag  cctgcgcac  ccatctccc  cccttttct  ctctctgtg  tggagaacc  2520
cagctgcag  gtagcagct  cctccagga  gagttactt  aaatttgcc  tgagtgtgt  2580
acctccttt  caagctcct  gtgataatg  agacttcct  gagtacaaa  acaggattt  2640
taattccta  tgtaacgga  tttagagcc  gggctgatg  tttggtgtg  ccagcactc  2700
gaaactgag  aatgttcag  atgtacgga  agatgatca  ctattttca  cataactga  2760
ggcatatgc  ggcccataa  caccctgta  gttcttgat  tttataata  aattggtgt  2820
ttgt  2824



<210> 9861
<211> 748
<212> PRT
<213> Homo sapiens
<308> Q03518
<400> 9861

Met Ala Ser Ser Arg Cys Pro Ala Pro Arg Gly Cys Arg Cys Leu Pro 
  1               5                  10                  15
Gly Ala Ser Leu Ala Trp Leu Gly Thr Val Leu Leu Leu Leu Ala Asp 
             20                  25                  30
Trp Val Leu Leu Arg Thr Ala Leu Pro Arg Ile Phe Ser Leu Leu Val 
         35                  40                  45
Pro Thr Ala Leu Pro Leu Leu Arg Val Trp Ala Val Gly Leu Ser Arg 
     50                  55                  60
Trp Ala Val Leu Trp Leu Gly Ala Cys Gly Val Leu Arg Ala Thr Val 
 65                  70                  75                  80
Gly Ser Lys Ser Glu Asn Ala Gly Ala Gln Gly Trp Leu Ala Ala Leu 
                 85                  90                  95
Lys Pro Leu Ala Ala Ala Leu Gly Leu Ala Leu Pro Gly Leu Ala Leu 
             100                105                110
Phe Arg Glu Leu Ile Ser Trp Gly Ala Pro Gly Ser Ala Asp Ser Thr 
         115                120                125
Arg Leu Leu His Trp Gly Ser His Pro Thr Ala Phe Val Val Ser Tyr 
     130                135                140
Ala Ala Ala Leu Pro Ala Ala Ala Leu Trp His Lys Leu Gly Ser Leu 
 145                150                155                160
Trp Val Pro Gly Gly Gln Gly Gly Ser Gly Asn Pro Val Arg Arg Leu 
                 165                170                175
Leu Gly Cys Leu Gly Ser Glu Thr Arg Arg Leu Ser Leu Phe Leu Val 
             180                185                190
Leu Val Val Leu Ser Ser Leu Gly Glu Met Ala Ile Pro Phe Phe Thr 
         195                200                205
Gly Arg Leu Thr Asp Trp Ile Leu Gln Asp Gly Ser Ala Asp Thr Phe 
     210                215                220
Thr Arg Asn Leu Thr Leu Met Ser Ile Leu Thr Ile Ala Ser Ala Val 
 225                230                235                240
Leu Glu Phe Val Gly Asp Gly Ile Tyr Asn Asn Thr Met Gly His Val 
                 245                250                255
His Ser His Leu Gln Gly Glu Val Phe Gly Ala Val Leu Arg Gln Glu 
             260                265                270
Thr Glu Phe Phe Gln Gln Asn Gln Thr Gly Asn Ile Met Ser Arg Val 
         275                280                285
Thr Glu Asp Thr Ser Thr Leu Ser Asp Ser Leu Ser Glu Asn Leu Ser 
     290                295                300
Leu Phe Leu Trp Tyr Leu Val Arg Gly Leu Cys Leu Leu Gly Ile Met 
 305                310                315                320
Leu Trp Gly Ser Val Ser Leu Thr Met Val Thr Leu Ile Thr Leu Pro 
                 325                330                335
Leu Leu Phe Leu Leu Pro Lys Lys Val Gly Lys Trp Tyr Gln Leu Leu 
             340                345                350
Glu Val Gln Val Arg Glu Ser Leu Ala Lys Ser Ser Gln Val Ala Ile 
         355                360                365
Glu Ala Leu Ser Ala Met Pro Thr Val Arg Ser Phe Ala Asn Glu Glu 
     370                375                380
Gly Glu Ala Gln Lys Phe Arg Glu Lys Leu Gln Glu Ile Lys Thr Leu 
 385                390                395                400
Asn Gln Lys Glu Ala Val Ala Tyr Ala Val Asn Ser Trp Thr Thr Ser 
                 405                410                415
Ile Ser Gly Met Leu Leu Lys Val Gly Ile Leu Tyr Ile Gly Gly Gln 
             420                425                430
Leu Val Thr Ser Gly Ala Val Ser Ser Gly Asn Leu Val Thr Phe Val 
         435                440                445
Leu Tyr Gln Met Gln Phe Thr Gln Ala Val Glu Val Leu Leu Ser Ile 
     450                455                460
Tyr Pro Arg Val Gln Lys Ala Val Gly Ser Ser Glu Lys Ile Phe Glu 
 465                470                475                480
Tyr Leu Asp Arg Thr Pro Arg Cys Pro Pro Ser Gly Leu Leu Thr Pro 
                 485                490                495
Leu His Leu Glu Gly Leu Val Gln Phe Gln Asp Val Ser Phe Ala Tyr 
             500                505                510
Pro Asn Arg Pro Asp Val Leu Val Leu Gln Gly Leu Thr Phe Thr Leu 
         515                520                525
Arg Pro Gly Glu Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys 
     530                535                540
Ser Thr Val Ala Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly 
 545                550                555                560
Gln Leu Leu Leu Asp Gly Lys Pro Leu Pro Gln Tyr Glu His Arg Tyr 
                 565                570                575
Leu His Arg Gln Val Ala Ala Val Gly Gln Glu Pro Gln Val Phe Gly 
             580                585                590
Arg Ser Leu Gln Glu Asn Ile Ala Tyr Gly Leu Thr Gln Lys Pro Thr 
         595                600                605
Met Glu Glu Ile Thr Ala Ala Ala Val Lys Ser Gly Ala His Ser Phe 
     610                615                620
Ile Ser Gly Leu Pro Gln Gly Tyr Asp Thr Glu Val Asp Glu Ala Gly 
 625                630                635                640
Ser Gln Leu Ser Gly Gly Gln Arg Gln Ala Val Ala Leu Ala Arg Ala 
                 645                650                655
Leu Ile Arg Lys Pro Cys Val Leu Ile Leu Asp Asp Ala Thr Ser Ala 
             660                665                670
Leu Asp Ala Asn Ser Gln Leu Gln Val Glu Gln Leu Leu Tyr Glu Ser 
         675                680                685
Pro Glu Arg Tyr Ser Arg Ser Val Leu Leu Ile Thr Gln His Leu Ser 
     690                695                700
Leu Val Glu Gln Ala Asp His Ile Leu Phe Leu Glu Gly Gly Ala Ile 
 705                710                715                720
Arg Glu Gly Gly Thr His Gln Gln Leu Met Glu Lys Lys Gly Cys Tyr 
                 725                730                735
Trp Ala Met Val Gln Ala Pro Ala Asp Ala Pro Glu 
             740                745



<210> 9862
<211> 1607
<212> DNA
<213> Rattus norvegicus
<308> X64401
<400> 9862

ggatgcaga  catcagagg  ccagctaga  ggacaacac  gaggagtaa  ttgctgaca  60
acctgcagg  atggacctg  tttcagctc  cacactgga  acctgggtc  tcctggcag  120
cgtcctggt  ctcctctac  gatttggga  ccgcacaca  ggacttttc  agaaacagg  180
gattcctgg  cccaaacct  tgccttttt  tggcactgt  ctgaattac  atatgggtt  240
atggaaatt  gatgtggag  gccataaaa  gtatggaaa  atatggggg  tgtttgatg  300
tcaaatgcc  ctgtttgcc  tcacggaca  agaaatgat  aagaatgtg  tagtgaagg  360
atgcttttc  gtcttcaca  accggcggg  ttttggccc  gtggggatt  tggggaaag  420
tgtctctgt  gctaaggat  aggagtgga  gagatatag  gccttgctg  cccccacgt  480
caccagtgg  agactcaag  agatgttcc  catcattga  cagtatgga  acattttgg  540
aaagtactt  aagcaagag  cggagacag  caagcctgt  accatgaaa  aagtgtttg  600
tgcctacag  atggatgtg  tcaccagca  atcatttgg  gtgaacgtc  attccctta  660
caacccaaa  gatcctttt  tggagaaag  caagaagct  ttaagaatt  atttttttg  720
tccgttgtt  ttgtcagta  tactctttc  attcctcac  ccagtatat  agatgttaa  780
catctgcat  ttcccaaaa  attcaatag  atttttcaa  aaatttgtg  acagaatga  840
ggaaacccg  ctggattct  tgcagaagc  tcgagtgga  tttcttcag  tgatgatga  900
tgctcataa  gattctaaa  acaaagaat  tcatacagc  ctatccgat  tggagatca  960
agcccagtc  atcattttt  tttttgctg  atatgaacc  accagcagc  cactttcct  1020
tgtcctgca  tccctggcc  ctcacccag  tacacagaa  aaactgcag  aggagatcg  1080
cagggctct  cccaataag  cacctccca  ctatgatac  gtgatggaa  tggaatacc  1140
ggatatggt  ttgaatgaa  ccctcagat  gtatccaat  ggtaataga  ttgagagag  1200
ctgtaaaaa  gatgttgaa  tcaatggtg  gtttatgcc  aaagggtca  tggtcatga  1260
tccatctta  gctcttcac  gtgatccac  gcactggcc  gagcctgag  aatttcgcc  1320
agaaaggtt  agcaaggag  acaagggca  cattgatcc  tatgtatat  tgccctttg  1380
aaatggacc  aggaactgc  ttggcatga  gtttgctct  atgaatatg  aactcgctc  1440
cactaaagt  ctgcaaaac  tctccttcc  gccttgtaa  gaaacacag  tacctctga  1500
attaagcag  caaggactt  ttcaaccaa  aaaacccat  attctaaag  ttgtgccac  1560
ggatgaaat  ataactgga  catgatttt  cctcaagga  ttctgct  1607



<210> 9863
<211> 504
<212> PRT
<213> Rattus norvegicus
<308> P04800
<400> 9863

Met Asp Leu Leu Ser Ala Leu Thr Leu Glu Thr Trp Val Leu Leu Ala 
  1               5                  10                  15
Val Val Leu Val Leu Leu Tyr Gly Phe Gly Thr Arg Thr His Gly Leu 
             20                  25                  30
Phe Lys Lys Gln Gly Ile Pro Gly Pro Lys Pro Leu Pro Phe Phe Gly 
         35                  40                  45
Thr Val Leu Asn Tyr Tyr Met Gly Leu Trp Lys Phe Asp Val Glu Cys 
     50                  55                  60
His Lys Lys Tyr Gly Lys Ile Trp Gly Leu Phe Asp Gly Gln Met Pro 
 65                  70                  75                  80
Leu Phe Ala Ile Thr Asp Thr Glu Met Ile Lys Asn Val Leu Val Lys 
                 85                  90                  95
Glu Cys Phe Ser Val Phe Thr Asn Arg Arg Asp Phe Gly Pro Val Gly 
             100                105                110
Ile Met Gly Lys Ala Val Ser Val Ala Lys Asp Glu Glu Trp Lys Arg 
         115                120                125
Tyr Arg Ala Leu Leu Ser Pro Thr Phe Thr Ser Gly Arg Leu Lys Glu 
     130                135                140
Met Phe Pro Ile Ile Glu Gln Tyr Gly Asp Ile Leu Val Lys Tyr Leu 
 145                150                155                160
Lys Gln Glu Ala Glu Thr Gly Lys Pro Val Thr Met Lys Lys Val Phe 
                 165                170                175
Gly Ala Tyr Ser Met Asp Val Ile Thr Ser Thr Ser Phe Gly Val Asn 
             180                185                190
Val Asp Ser Leu Asn Asn Pro Lys Asp Pro Phe Val Glu Lys Thr Lys 
         195                200                205
Lys Leu Leu Arg Phe Asp Phe Phe Asp Pro Leu Phe Leu Ser Val Val 
     210                215                220
Leu Phe Pro Phe Leu Thr Pro Ile Tyr Glu Met Leu Asn Ile Cys Met 
 225                230                235                240
Phe Pro Lys Asp Ser Ile Glu Phe Phe Lys Lys Phe Val Tyr Arg Met 
                 245                250                255
Lys Glu Thr Arg Leu Asp Ser Val Gln Lys His Arg Val Asp Phe Leu 
             260                265                270
Gln Leu Met Met Asn Ala His Asn Asp Ser Lys Asp Lys Glu Ser His 
         275                280                285
Thr Ala Leu Ser Asp Met Glu Ile Thr Ala Gln Ser Ile Ile Phe Ile 
     290                295                300
Phe Ala Gly Tyr Glu Pro Thr Ser Ser Thr Leu Ser Phe Val Leu His 
 305                310                315                320
Ser Leu Ala Thr His Pro Asp Thr Gln Lys Lys Leu Gln Glu Glu Ile 
                 325                330                335
Asp Arg Ala Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Thr Val Met 
             340                345                350
Glu Met Glu Tyr Leu Asp Met Val Leu Asn Glu Thr Leu Arg Leu Tyr 
         355                360                365
Pro Ile Gly Asn Arg Leu Glu Arg Val Cys Lys Lys Asp Val Glu Ile 
     370                375                380
Asn Gly Val Phe Met Pro Lys Gly Ser Val Val Met Ile Pro Ser Tyr 
 385                390                395                400
Ala Leu His Arg Asp Pro Gln His Trp Pro Glu Pro Glu Glu Phe Arg 
                 405                410                415
Pro Glu Arg Phe Ser Lys Glu Asn Lys Gly Ser Ile Asp Pro Tyr Val 
             420                425                430
Tyr Leu Pro Phe Gly Asn Gly Pro Arg Asn Cys Ile Gly Met Arg Phe 
         435                440                445
Ala Leu Met Asn Met Lys Leu Ala Leu Thr Lys Val Leu Gln Asn Phe 
     450                455                460
Ser Phe Gln Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Ser Arg 
 465                470                475                480
Gln Gly Leu Leu Gln Pro Thr Lys Pro Ile Ile Leu Lys Val Val Pro 
                 485                490                495
Arg Asp Glu Ile Ile Thr Gly Ser 
             500



<210> 9864
<211> 1707
<212> DNA
<213> Homo sapiens
<308> J04813
<400> 9864

gggaagctc  aggcaaaca  cccagcaaa  agcagcact  agctaaaag  aagactcac  60
gaacacagt  gaagaagga  agtggcgat  gacctcatc  caaatttgg  ggtggaaac  120
tggcttctc  tggctgtca  cctggtgct  ctctatcta  atgggaccc  tacacatgg  180
ctttttaag  gactgggaa  tccagggcc  acacctctg  ctttgttgg  aaatgtttt  240
tcctatcgt  agggtctct  gaaatttga  acagagtgc  ataaaaagt  tggaaaaat  300
tggggaacg  atgaaggtc  actccctgt  ctggccatc  cagatcccg  cgtgatcag  360
acagtgcta  tgaaagaat  ttattctgt  ttcacaaat  gaaggtctt  aggcccagt  420
ggatttatg  aaagtgcca  ctctttagc  gaggatgaa  aatggaaga  aatacggtc  480
ttgctgtct  caaccttca  cagcggaaa  ctcaaggag  tgttcccca  cattgccca  540
tatggagat  tattggtga  aaacttgag  cgggaagca  agaaaggca  gcctgtcac  600
ttgaaagac  tctttgggg  ctacagcat  gatgtgatt  ctggcacat  atttggagt  660
aacatcgac  ctctcaaca  tccacaaga  ccctttgtg  agagcacta  gaagttcct  720
aaatttggt  tcttagatc  attatttct  tcaataata  tctttccat  ccttacccc  780
gtttttgaa  cattaaatg  ctctctgtt  ccaaaagat  ccataaatt  tttaagtaa  840
tctgtaaac  gaatgaaga  aagtcgcct  aacgacaaa  aaaagcacc  actagattt  900
cttcagctg  tgattgact  ccagaattc  aaagaaact  agtcccaca  agctctgtc  960
gatctggag  tcgcagccc  gtcaataat  ttcattttt  ctggctatg  aaccaccag  1020
agtgttctt  ccttcactt  atatgaact  gccactcac  ctgatgtcc  gcagaaact  1080
caaaaggag  ttgatgcag  tttgcccaa  aaggcacca  ctacctatg  tgccgtggt  1140
cagatggag  accttgaca  ggtggtgaa  gaaacactc  gattattcc  agttgctat  1200
agacttgag  ggacttgca  gaaagatgt  gaaatcaat  gggtattca  tcccaaagg  1260
tcaatggtg  tgattccaa  ttatgctct  caccatgac  caaagtact  gacagagcc  1320
gaggagttc  gccctgaaa  gttcagtaa  aagaaggac  gcatagatc  ttacatata  1380
acacccttt  gaactggac  cagaaactg  attggcatg  ggtttgctc  catgaacat  1440
aaacttgct  taatcagag  ccttcagaa  ttctccttc  aaccttgta  agaaacaca  1500
atccccttg  aattagaca  gcaaggact  cttcaacca  aaaaaccca  tgttctaaa  1560
gtggattca  gagatggaa  cctaagtgg  gaatgagtt  ttctaagga  ttctacttt  1620
gtcttcaag  aagctgtgc  ccagaacac  agagatttc  acttagtca  taaaacctt  1680
aaataaaga  gggcttaat  taatgta  1707



<210> 9865
<211> 502
<212> PRT
<213> Homo sapiens
<308> P20815
<400> 9865

Met Asp Leu Ile Pro Asn Leu Ala Val Glu Thr Trp Leu Leu Leu Ala 
  1               5                  10                  15
Val Ser Leu Val Leu Leu Tyr Leu Tyr Gly Thr Arg Thr His Gly Leu 
             20                  25                  30
Phe Lys Arg Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly 
         35                  40                  45
Asn Val Leu Ser Tyr Arg Gln Gly Leu Trp Lys Phe Asp Thr Glu Cys 
     50                  55                  60
Tyr Lys Lys Tyr Gly Lys Met Trp Gly Thr Tyr Glu Gly Gln Leu Pro 
 65                  70                  75                  80
Val Leu Ala Ile Thr Asp Pro Asp Val Ile Arg Thr Val Leu Val Lys 
                 85                  90                  95
Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Ser Leu Gly Pro Val Gly 
             100                105                110
Phe Met Lys Ser Ala Ile Ser Leu Ala Glu Asp Glu Glu Trp Lys Arg 
         115                120                125
Ile Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
     130                135                140
Met Phe Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
 145                150                155                160
Arg Arg Glu Ala Glu Lys Gly Lys Pro Val Thr Leu Lys Asp Ile Phe 
                 165                170                175
Gly Ala Tyr Ser Met Asp Val Ile Thr Gly Thr Ser Phe Gly Val Asn 
             180                185                190
Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Ser Thr Lys 
         195                200                205
Lys Phe Leu Lys Phe Gly Phe Leu Asp Pro Leu Phe Leu Ser Ile Ile 
     210                215                220
Leu Phe Pro Phe Leu Thr Pro Val Phe Glu Ala Leu Asn Val Ser Leu 
 225                230                235                240
Phe Pro Lys Asp Thr Ile Asn Phe Leu Ser Lys Ser Val Asn Arg Met 
                 245                250                255
Lys Lys Ser Arg Leu Asn Asp Lys Gln Lys His Arg Leu Asp Phe Leu 
             260                265                270
Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Glu Ser His Lys 
         275                280                285
Ala Leu Ser Asp Leu Glu Leu Ala Ala Gln Ser Ile Ile Phe Ile Phe 
     290                295                300
Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Thr Leu Tyr Glu 
 305                310                315                320
Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Lys Glu Ile Asp 
                 325                330                335
Ala Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Ala Val Val Gln 
             340                345                350
Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
         355                360                365
Val Ala Ile Arg Leu Glu Arg Thr Cys Lys Lys Asp Val Glu Ile Asn 
     370                375                380
Gly Val Phe Ile Pro Lys Gly Ser Met Val Val Ile Pro Thr Tyr Ala 
 385                390                395                400
Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Glu Phe Arg Pro 
                 405                410                415
Glu Arg Phe Ser Lys Lys Lys Asp Ser Ile Asp Pro Tyr Ile Tyr Thr 
             420                425                430
Pro Phe Gly Thr Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala Leu 
         435                440                445
Met Asn Met Lys Leu Ala Leu Ile Arg Val Leu Gln Asn Phe Ser Phe 
     450                455                460
Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Asp Thr Gln Gly 
 465                470                475                480
Leu Leu Gln Pro Glu Lys Pro Ile Val Leu Lys Val Asp Ser Arg Asp 
                 485                490                495
Gly Thr Leu Ser Gly Glu 
             500



<210> 9866
<211> 1430
<212> DNA
<213> Rattus norvegicus
<308> X64403
<400> 9866

ggccgcggt  gcggaacgg  cggaggctg  cggtttcgt  accgtcgct  ctcctcgcc  60
actcgcagg  tgcgaggcc  gggtagggt  ggaccgcgc  gcgcggggc  gctcggagt  120
gaggccgtc  gggggcggg  gggccggcc  gaggcgcag  tacatgtga  gattttttg  180
cagttgagt  tggccttct  ggatcacac  gctctgatt  ctacgtgtt  tgtgttggt  240
gaggaacgg  cccaaatga  caagctgtc  cagccagcc  cgactgcag  agtgaacgg  300
atcagtgtc  ttcacactc  ggcacatgc  agcggctta  agcaggttc  tcagctggt  360
cccgctggg  ctgggggag  aggcaaagc  gtgcctcca  gcaagcaaa  caagaagag  420
tcacccatg  atcgaaata  cgatgagta  cgccagcgc  gagagcgga  caatatggc  480
gtgaaaaag  gccggttaa  aagcaagca  aaagctcaa  atacactgc  gagagtaaa  540
cagctcaag  aggagaacg  gcggctgga  gccaaaatt  agttgctga  aaaggaatt  600
agtgtactg  aagacttgt  tcttgagca  gcgcacaac  tcgcagaca  tgtgcagcc  660
atcagcacg  aaactacgg  ggcaaattc  gataacaca  ggcagtaga  ctccttcca  720
gcgccacag  cttgtgact  gaacatgag  ggtgtgacc  ccctgcacc  cttggttca  780
tggctgagc  cggtcttgt  ccattggag  ttatttttt  ggctcagca  tggacagct  840
gttagccat  taatttatc  ggtcttaaa  gataatgga  ttttgaagc  ctaaaagaa  900
acttagggt  tatggttaa  ataaaattc  tggccttta  tattcttaa  aaatcctca  960
ttccccaga  atgcttctt  tgtaggaag  ggaaaatgg  aggtcatat  gaaggttct  1020
ggttctaat  agataatac  ttggactag  aaaagctga  ttccatctg  gttcttcaa  1080
ttgtgattt  attctaaat  gtgtatgat  aattctagg  ctatagaaa  cagccataa  1140
aatttggcc  aattttata  atgtataaa  ctgtgttag  ataatcagc  tcgtttttt  1200
caacacata  acattttaa  aaatgacct  aggtgaagt  aagaaatcc  atcaggtca  1260
gtcgagagg  ggttaaaaa  acaagttgt  tttaggaag  aaagaggtg  ttttgtgct  1320
ttccccctt  tttgtttta  agggcatag  gtgtgattg  actttgggg  gccttctgc  1380
tattggatg  gcattatct  tatcctaaa  gacagtagc  accgtgtact  1430



<210> 9867
<211> 150
<212> PRT
<213> Rattus norvegicus
<308> P26801
<400> 9867

Met Ser Lys Leu Ser Gln Pro Ala Ser Thr Ala Gly Val Asn Gly Ile 
  1               5                  10                  15
Ser Val Ile His Thr Gln Ala His Ala Ser Gly Leu Gln Gln Val Pro 
             20                  25                  30
Gln Leu Val Pro Ala Gly Pro Gly Gly Gly Gly Lys Ala Val Pro Pro 
         35                  40                  45
Ser Lys Gln Ser Lys Lys Ser Ser Pro Met Asp Arg Asn Ser Asp Glu 
     50                  55                  60
Tyr Arg Gln Arg Arg Glu Arg Asn Asn Met Ala Val Lys Lys Ser Arg 
 65                  70                  75                  80
Leu Lys Ser Lys Gln Lys Ala Gln Asp Thr Leu Gln Arg Val Asn Gln 
                 85                  90                  95
Leu Lys Glu Glu Asn Glu Arg Leu Glu Ala Lys Ile Lys Leu Leu Thr 
             100                105                110
Lys Glu Leu Ser Val Leu Lys Asp Leu Phe Leu Glu His Ala His Asn 
         115                120                125
Leu Ala Asp Asn Val Gln Pro Ile Ser Thr Glu Thr Thr Val Ala Asn 
     130                135                140
Ser Asp Asn Thr Gly Gln 
 145                150



<210> 9868
<211> 1001
<212> DNA
<213> Homo sapiens
<308> U20240
<400> 9868

gccgcggct  cggaacggg  ggaggctgc  ggtttcgta  ccgtcgctc  tcctcgctg  60
ctcgcgggc  gtgaggcct  ggtcggctc  ggccgcacc  cgcggggcc  ctcggagtg  120
aggccgcct  ggggcaggc  ggctagagg  gcaggtaca  gtgaagatt  tttggcagc  180
tagcgtgga  accattgat  accctgctc  catttctac  tgttctgtg  tggcaaggg  240
gagtgccca  atgagcaag  tatcgcagc  aaacagcac  ccaggggtg  acggaatta  300
tgttatcca  acccaggca  atgccagcg  cttacagca  gttcctcag  tggtgcctg  360
tggccctgg  ggaggaggc  aagctgtgg  tcccagcaa  cagagcaaa  agagttcgc  420
catggatcg  aacagtgac  agtatcggc  acgccgaga  aggaacaac  tggctgtga  480
aaagagccg  ttgaaaagc  agcagaaag  acaagacac  ctgcagaga  tcaatcagc  540
caaagaaga  aatgaacgg  tggaagcaa  aatcaaatt  ctgaccaag  aattaagtg  600
actcaaaga  ttgtttctt  agcatgcac  caaccttgc  gacaacgta  agtccatta  660
cactgaaaa  acgacagca  atggcgaca  tgcaggaca  tagacctca  cctttccag  720
ctttagagc  tgtggcttg  atgttaaag  tgtgaccac  gacaccact  atgtcaatg  780
ctgaaagtt  tccatttcc  tgactcaaa  acccattgg  ggctatttt  tgggatcag  840
actgaagag  tgattagct  aaaatgtta  ccttgtaat  cgaatatct  gttttaaat  900
atagaggtt  ttgtgggaa  caaaatccc  caaatgtta  ggtatatgg  aaaaaaaga  960
atatctggg  tcccgatgt  cttaataaa  cctgacttc  c  1001



<210> 9869
<211> 150
<212> PRT
<213> Homo sapiens
<308> P53567
<400> 9869

Met Ser Lys Ile Ser Gln Gln Asn Ser Thr Pro Gly Val Asn Gly Ile 
  1               5                  10                  15
Ser Val Ile His Thr Gln Ala His Ala Ser Gly Leu Gln Gln Val Pro 
             20                  25                  30
Gln Leu Val Pro Ala Gly Pro Gly Gly Gly Gly Lys Ala Val Ala Pro 
         35                  40                  45
Ser Lys Gln Ser Lys Lys Ser Ser Pro Met Asp Arg Asn Ser Asp Glu 
     50                  55                  60
Tyr Arg Gln Arg Arg Glu Arg Asn Asn Met Ala Val Lys Lys Ser Arg 
 65                  70                  75                  80
Leu Lys Ser Lys Gln Lys Ala Gln Asp Thr Leu Gln Arg Val Asn Gln 
                 85                  90                  95
Leu Lys Glu Glu Asn Glu Arg Leu Glu Ala Lys Ile Lys Leu Leu Thr 
             100                105                110
Lys Glu Leu Ser Val Leu Lys Asp Leu Phe Leu Glu His Ala His Asn 
         115                120                125
Leu Ala Asp Asn Val Gln Ser Ile Ser Thr Glu Asn Thr Thr Ala Asp 
     130                135                140
Gly Asp Asn Ala Gly Gln 
 145                150



<210> 9870
<211> 534
<212> DNA
<213> Rattus norvegicus
<308> X65228
<400> 9870

ccttttttc  ccaagatgg  gccgaaagc  aagaaggaa  ctcctgccc  tcccaaagc  60
gaagccaaa  cgaaggcct  gaaagctaa  aaggcagtg  tgaaaggtg  ccacagtca  120
aaaaagaag  agatccgaa  gtcacccac  ttccggcgg  ccaagaccc  gcggctccg  180
aggcagcca  aatatcctc  aaagagtgc  cccaggaga  acaagcttg  ccactatgc  240
atcatcaaa  tcccactga  caccgagtc  gctatgaag  aaatagagg  caacaacac  300
cttgtgttc  ttgtggatg  taaggccaa  aagcaccag  tcaaacagg  cgtgaaaaa  360
ctctatgat  tagatgtgg  caaagtcaa  actctgata  ggcctgacg  agagaagaa  420
gcatatgtt  gcttggctc  tgattatga  gctctagat  ttgccaaca  gattgggat  480
atctaaagt  agtccagat  gttaattct  aatatatac  ttttttcca  cata  534



<210> 9871
<211> 156
<212> PRT
<213> Rattus norvegicus
<308> CAA46336
<400> 9871

Met Ala Pro Lys Ala Lys Lys Glu Ala Pro Ala Pro Pro Lys Ala Glu 
  1               5                  10                  15
Ala Lys Ala Lys Ala Leu Lys Ala Lys Lys Ala Val Leu Lys Gly Val 
             20                  25                  30
His Ser His Lys Lys Lys Lys Ile Arg Thr Ser Pro Thr Phe Arg Arg 
         35                  40                  45
Pro Lys Thr Leu Arg Leu Arg Arg Gln Pro Lys Tyr Pro Arg Lys Ser 
     50                  55                  60
Ala Pro Arg Arg Asn Lys Leu Asp His Tyr Ala Ile Ile Lys Phe Pro 
 65                  70                  75                  80
Leu Thr Thr Glu Ser Ala Met Lys Lys Ile Glu Asp Asn Asn Thr Leu 
                 85                  90                  95
Val Phe Ile Val Asp Val Lys Ala Asn Lys His Gln Ile Lys Gln Ala 
             100                105                110
Val Lys Lys Leu Tyr Asp Ile Asp Val Ala Lys Val Asn Thr Leu Ile 
         115                120                125
Arg Pro Asp Gly Glu Lys Lys Ala Tyr Val Arg Leu Ala Pro Asp Tyr 
     130                135                140
Asp Ala Leu Asp Val Ala Asn Lys Ile Gly Ile Ile 
 145                150                155



<210> 9872
<211> 546
<212> DNA
<213> Homo sapiens
<308> NM_000984
<400> 9872

attggagac  cttttcaca  gatggcgcc  aaagcgaag  aggaagctc  tgcccctcc  60
aaagctgaa  ccaaagcga  ggctttaaa  gccaagaag  cagtgttga  aggtgtcca  120
agccacaaa  agaagaaga  ccgcacgtc  cccaccttc  ggcggccga  gacactgcg  180
ctccggaga  agcccaaat  tcctcggaa  agcgctccc  ggagaaaca  gcttgacca  240
tatgctatc  tcaagtttc  gctgaccac  gagtctgcc  tgaagaaga  agaagacaa  300
aacacactt  tgttcattg  ggatgttaa  gccaacaag  accagatta  acaggctgt  360
aagaagctg  atgacattg  tgtggccaa  gtcaacacc  tgattcggc  tgatggaga  420
aagaaggca  atgttcgac  ggctcctga  tacgatgct  tggatgttg  caacaaaat  480
gggatcatc  aaactgagt  cagctgcct  attctgaat  tatatatat  tatatcttt  540
caccat  546



<210> 9873
<211> 156
<212> PRT
<213> Homo sapiens
<308> P29316
<400> 9873

Met Ala Pro Lys Ala Lys Lys Glu Ala Pro Ala Pro Pro Lys Ala Glu 
  1               5                  10                  15
Ala Lys Ala Lys Ala Leu Lys Ala Lys Lys Ala Val Leu Lys Gly Val 
             20                  25                  30
His Ser His Lys Lys Lys Lys Ile Arg Thr Ser Pro Thr Phe Arg Arg 
         35                  40                  45
Pro Lys Thr Leu Arg Leu Arg Arg Gln Pro Lys Tyr Pro Arg Lys Ser 
     50                  55                  60
Ala Pro Arg Arg Asn Lys Leu Asp His Tyr Ala Ile Ile Lys Phe Pro 
 65                  70                  75                  80
Leu Thr Thr Glu Ser Ala Met Lys Lys Ile Glu Asp Asn Asn Thr Leu 
                 85                  90                  95
Val Phe Ile Val Asp Val Lys Ala Asn Lys His Gln Ile Lys Gln Ala 
             100                105                110
Val Lys Lys Leu Tyr Asp Ile Asp Val Ala Lys Val Asn Thr Leu Ile 
         115                120                125
Arg Pro Asp Gly Glu Lys Lys Ala Tyr Val Arg Leu Ala Pro Asp Tyr 
     130                135                140
Asp Ala Leu Asp Val Ala Asn Lys Ile Gly Ile Ile 
 145                150                155



<210> 9874
<211> 1407
<212> DNA
<213> Rattus norvegicus
<308> X65454
<400> 9874

gaattcccc  gaggacctg  tgcctctgg  cacggccta  ggccacgct  tggagcagt  60
tgaagggga  agctggcgc  agagcgcgc  ctacctgga  gcggcgctg  ggctgcatc  120
gctgctgcg  gacagtgag  ccttctgcc  cgccaactg  agcggcccc  ccacctcgc  180
gccccggcc  gctcccggc  ccgacggcg  caacgaggg  gatggcgag  attgggcgc  240
cgagctgcg  ctcttcggc  acgtcctgg  gcgtgccgc  tgtttgcgg  gctgcaagc  300
gactctgcc  gccttccaa  tcccctacc  gtcgcggca  ctactgcgc  acttccaga  360
ccgcctgcc  taccagtac  tgcactacg  gcacttcaa  gcgaaccga  tagagaagg  420
ggtggctgc  gcctacacc  tcctccaga  gaaccccaa  cacgagctg  ccgccaagt  480
tctcaacta  tacagggga  tgctggata  cggagatga  tccctcact  atctggagg  540
ccagcccta  gaggctgtg  tccttcagg  tgtgaagct  tacaacagc  gggactttc  600
cagcagcac  gaacacatg  agcgggcct  ggctgatta  atgaccgtc  ttgctcggt  660
tctagctgg  tgtgaaggg  cccacgagc  ggtagactt  aaggacttc  acccagcca  720
agcagatct  ttcgcagaa  ccctgcagt  caaggtgga  tgtgaagcc  atctcaccc  780
caacgtagg  ggcttcttt  tggacaagt  cgtggccac  atgtatcac  acctgcagt  840
tgcctacta  aaattgaac  atgtgcacc  ggctgcccg  agcgctgct  gctacatgc  900
ctttgaccc  aaggacagt  tcatgcagc  gaacctggt  tattaccgc  tccaccggg  960
tcgctgggg  cttgaagag  aggacttcc  gccccggga  gaagctgtg  tctaccaca  1020
ccagacctc  gaacttcgg  agttgctag  cttcacaca  atgtacctt  agtcagatg  1080
tgagatgga  ctggaggag  cggaatcac  tccggagcc  gaaaaacct  tgtctgatg  1140
cgagttcga  ggcgagggc  actatgagg  gggcctcta  gcggactgg  gcaggagcc  1200
gatgccaag  gtgatgagg  tgaggctga  ccagagcct  aactggcct  agacagtga  1260
atggtgcac  cttcaagct  aggacacct  gctgggggc  ggaactatt  attaaaact  1320
aaaatcggg  ttggggatt  agctcagtg  tagagcact  gcctagcaa  cacaaggcc  1380
tgggttcgg  ccctagctc  ggaattc  1407



<210> 9875
<211> 431
<212> PRT
<213> Rattus norvegicus
<308> Q64375
<400> 9875

Met Pro Leu Ala Thr Ala Tyr Gly His Ala Leu Glu Gln Tyr Glu Gly 
  1               5                  10                  15
Glu Ser Trp Arg Glu Ser Ala Arg Tyr Leu Glu Ala Ala Leu Arg Leu 
             20                  25                  30
His Arg Leu Leu Arg Asp Ser Glu Ala Phe Cys His Ala Asn Cys Ser 
         35                  40                  45
Gly Pro Ala Thr Ser Gln Pro Arg Pro Ala Pro Gly Pro Asp Gly Asp 
     50                  55                  60
Asn Glu Gly Asp Gly Glu Asp Trp Ala Arg Glu Leu Arg Leu Phe Gly 
 65                  70                  75                  80
His Val Leu Glu Arg Ala Ala Cys Leu Arg Arg Cys Lys Arg Thr Leu 
                 85                  90                  95
Pro Ala Phe Gln Val Pro Tyr Pro Ser Arg Gln Leu Leu Arg Asp Phe 
             100                105                110
Gln Asn Arg Leu Pro Tyr Gln Tyr Leu His Tyr Ala His Phe Lys Ala 
         115                120                125
Asn Arg Leu Glu Lys Ala Val Ala Ala Ala Tyr Thr Phe Leu Gln Arg 
     130                135                140
Asn Pro Lys His Glu Leu Thr Ala Lys Tyr Leu Asn Tyr Tyr Arg Gly 
 145                150                155                160
Met Leu Asp Ile Gly Asp Glu Ser Leu Thr Asp Leu Glu Ala Gln Pro 
                 165                170                175
Tyr Glu Ala Val Phe Leu Gln Ala Val Lys Leu Tyr Asn Ser Gly Asp 
             180                185                190
Phe Arg Ser Ser Thr Glu His Met Glu Arg Ala Leu Ala Asp Tyr Met 
         195                200                205
Thr Val Phe Ala Arg Cys Leu Ala Gly Cys Glu Gly Ala His Glu Gln 
     210                215                220
Val Asp Phe Lys Asp Phe Tyr Pro Ala Ile Ala Asp Leu Phe Ala Glu 
 225                230                235                240
Ser Leu Gln Cys Lys Val Asp Cys Glu Ala Asn Leu Thr Pro Asn Val 
                 245                250                255
Gly Gly Phe Phe Val Asp Lys Phe Val Ala Thr Met Tyr His Tyr Leu 
             260                265                270
Gln Phe Ala Tyr Tyr Lys Leu Asn Asp Val His Gln Ala Ala Arg Ser 
         275                280                285
Ala Ala Ser Tyr Met Leu Phe Asp Pro Lys Asp Ser Val Met Gln Gln 
     290                295                300
Asn Leu Val Tyr Tyr Arg Phe His Arg Ala Arg Trp Gly Leu Glu Glu 
 305                310                315                320
Glu Asp Phe Gln Pro Arg Glu Glu Ala Val Leu Tyr His Asn Gln Thr 
                 325                330                335
Ser Glu Leu Arg Glu Leu Leu Asp Phe Thr His Met Tyr Leu Gln Ser 
             340                345                350
Asp Asp Glu Met Glu Leu Glu Glu Thr Glu Ser Leu Pro Glu Pro Glu 
         355                360                365
Lys Pro Leu Ser Asp Ala Glu Phe Glu Gly Glu Gly Asp Tyr Glu Glu 
     370                375                380
Gly Leu Tyr Ala Asp Trp Cys Arg Ser Arg Met Pro Arg Val Met Arg 
 385                390                395                400
Met Arg Leu Ser Gln Ser Leu Asn Trp Pro Lys Thr Val Thr Trp Cys 
                 405                410                415
Thr Leu Gln Ala Gln Asp Thr Trp Leu Gly Ala Gly Thr Ile Tyr 
             420                425                430



<210> 9876
<211> 2347
<212> DNA
<213> Homo sapiens
<308> U47621
<400> 9876

gcgcggcgg  catggctcg  gtggcgtgg  ggctgctgt  gttgctgct  ggcagcgcc  60
gggcgcagt  cgagaagta  agcttccgg  gcttcccgc  cgaggacct  atgccgctg  120
ccgcggcgt  cgggcacgc  ctggagcag  acgagggag  gagctggcg  gagagcgcg  180
gctacctgg  ggcggcgct  cggctgcac  ggctcctgc  cgacagcga  gccttctgc  240
acgccaact  cagcggccc  gcgcccgcg  ccaagcccg  tcccgacgg  ggccgcgca  300
acgagtggg  ctgcgagct  cggctcttc  gccgcgtcc  ggagcgagc  gcctgcctg  360
ggcgctgca  gcggacgct  cccgccttc  aggtgccct  cccgccgcg  cagctgctg  420
gtgacttcc  gagccgcct  ccctaccag  acctgcact  cgcgctgtt  aaggctaac  480
ggctggaga  ggcggtggc  gcggcctac  ccttcctcc  gaggaaccc  aagcacgag  540
tgaccgcca  gtatctcaa  tactatcag  ggatgctgg  cgtcgccga  gagtccctc  600
cggacctag  ggcccagcc  tacgaggcc  tgttcctcc  ggctgtgaa  ctctacaac  660
gcggggatt  ccgcagcag  acggaggac  tggagcggg  cttgtcaga  tacctggca  720
tctttgccc  gtgcctggc  ggctgtgaa  gggcccatg  gcaggtgga  ttcaaggac  780
tctacccgg  catagcaga  ctctttgca  agtccctgc  gtgcaaggt  gactgtgag  840
ccaatttga  ccccaatgt  ggtggctac  tcgtggaca  gttcgtggc  accatgtac  900
actacctgc  gtttgccta  tataagttg  atgatgtgc  ccaggctgc  cgcagcgcc  960
ccagctaca  gctcttcga  cccaaggac  gcgtcatgc  gcagaacct  gtgtattac  1020
ggttccacc  ggctcgctg  ggcctggaa  aggaggact  ccagccccg  gaggaggcc  1080
tgctctacc  caaccagac  gccgagctg  gggagctgc  ggagttcac  cacatgtac  1140
tgcagtcag  tgatgagat  gagctggag  agacagaac  gcccctgga  cctgaggat  1200
ccctatctg  cgccgagtt  gagggggag  gtgactacg  ggagggcat  tatgctgac  1260
ggtggcagg  gccggatgc  aagggtgac  aggccgagg  tgagccaga  cctgaactc  1320
catgagaag  ggacacccc  caccgctca  gcttgggaa  cctggtgcc  atggcccca  1380
cctcaccag  ctgggcagc  gcaagaact  tttattaaa  acttaagat  ggccaggtg  1440
ggtggctca  acctgtaat  ccagcattt  gggaggcca  ggtgggtgg  tcacttgag  1500
ccaggagtt  aagaccagc  tggccaaca  gatgagacc  ccgtctcta  taaaataca  1560
aaattagcc  ggtgtggtg  caggcgcct  aaatcccag  tactcaaga  gctgaggca  1620
gagaatcgc  tgaacctgg  aggcaaagg  tgcggtgaa  tgagattgc  ccaccgcac  1680
ccagcctgg  cgacagagc  agactccat  tttaaaaaa  aacaagacg  gccggcacg  1740
tggctcacg  ctgtaatcc  agcactgag  ggccgatca  ttgaggtca  gagttcaag  1800
cctgcctgg  caacatggt  aaaccccat  tctactaaa  aatacaaaa  ttagccagg  1860
atggtggca  acacctgta  tcgtagctg  ggcaggaga  tcgcctgaa  ccaggaggc  1920
gagcttgca  tgagccgag  tcgtgccac  gcactccag  ctgggcgac  gagtgagac  1980
ccatctcaa  aaaaaaaaa  aaaaactta  gatggacac  gctgactgg  cccccatcc  2040
gcctcaccc  tgggtgctg  accccagac  catcctgcc  cttctatgt  tctggacca  2100
aggatggtg  tggcattgc  ggttggcaa  tgggctgat  gggtccgcc  tcctcactg  2160
tgagctcct  acctggaca  tctcctgga  aaggagttt  cagctgctg  ctggagtct  2220
aggccaaat  gcagagggt  ctccagggt  ctgaagagc  ctggactaa  agtctagtg  2280
ttccagggc  ctgaccagt  ggtgctcaa  aaatgtttg  tgttgaatg  aaaaaaaaa  2340
aaaaaaa  2347



<210> 9877
<211> 437
<212> PRT
<213> Homo sapiens
<308> Q92791
<400> 9877

Met Ala Arg Val Ala Trp Gly Leu Leu Trp Leu Leu Leu Gly Ser Ala 
  1               5                  10                  15
Gly Ala Gln Tyr Glu Lys Tyr Ser Phe Arg Gly Phe Pro Pro Glu Asp 
             20                  25                  30
Leu Met Pro Leu Ala Ala Ala Tyr Gly His Ala Leu Glu Gln Tyr Glu 
         35                  40                  45
Gly Glu Ser Trp Arg Glu Ser Ala Arg Tyr Leu Glu Ala Ala Leu Arg 
     50                  55                  60
Leu His Arg Leu Leu Arg Asp Ser Glu Ala Phe Cys His Ala Asn Cys 
 65                  70                  75                  80
Ser Gly Pro Ala Pro Ala Ala Lys Pro Asp Pro Asp Gly Gly Arg Ala 
                 85                  90                  95
Asp Glu Trp Ala Cys Glu Leu Arg Leu Phe Gly Arg Val Leu Glu Arg 
             100                105                110
Ala Ala Cys Leu Arg Arg Cys Lys Arg Thr Leu Pro Ala Phe Gln Val 
         115                120                125
Pro Tyr Pro Pro Arg Gln Leu Leu Arg Asp Phe Gln Ser Arg Leu Pro 
     130                135                140
Tyr Gln Tyr Leu His Tyr Ala Leu Phe Lys Ala Asn Arg Leu Glu Lys 
 145                150                155                160
Ala Val Ala Ala Ala Tyr Thr Phe Leu Gln Arg Asn Pro Lys His Glu 
                 165                170                175
Leu Thr Ala Lys Tyr Leu Asn Tyr Tyr Gln Gly Met Leu Asp Val Ala 
             180                185                190
Asp Glu Ser Leu Thr Asp Leu Glu Ala Gln Pro Tyr Glu Ala Val Phe 
         195                200                205
Leu Arg Ala Val Lys Leu Tyr Asn Ser Gly Asp Phe Arg Ser Ser Thr 
     210                215                220
Glu Asp Met Glu Arg Ala Leu Ser Glu Tyr Leu Ala Val Phe Ala Arg 
 225                230                235                240
Cys Leu Ala Gly Cys Glu Gly Ala His Glu Gln Val Asp Phe Lys Asp 
                 245                250                255
Phe Tyr Pro Ala Ile Ala Asp Leu Phe Ala Glu Ser Leu Gln Cys Lys 
             260                265                270
Val Asp Cys Glu Ala Asn Leu Thr Pro Asn Val Gly Gly Tyr Phe Val 
         275                280                285
Asp Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala Tyr Tyr 
     290                295                300
Lys Leu Asn Asp Val Arg Gln Ala Ala Arg Ser Ala Ala Ser Tyr Met 
 305                310                315                320
Leu Phe Asp Pro Lys Asp Ser Val Met Gln Gln Asn Leu Val Tyr Tyr 
                 325                330                335
Arg Phe His Arg Ala Arg Trp Gly Leu Glu Glu Glu Asp Phe Gln Pro 
             340                345                350
Arg Glu Glu Ala Met Leu Tyr His Asn Gln Thr Ala Glu Leu Arg Glu 
         355                360                365
Leu Leu Glu Phe Thr His Met Tyr Leu Gln Ser Asp Asp Glu Met Glu 
     370                375                380
Leu Glu Glu Thr Glu Pro Pro Leu Glu Pro Glu Asp Ala Leu Ser Asp 
 385                390                395                400
Ala Glu Phe Glu Gly Glu Gly Asp Tyr Glu Glu Gly Met Tyr Ala Asp 
                 405                410                415
Trp Trp Gln Glu Pro Asp Ala Lys Gly Asp Glu Ala Glu Ala Glu Pro 
             420                425                430
Glu Pro Glu Leu Ala 
         435



<210> 9878
<211> 1407
<212> DNA
<213> Rattus norvegicus
<308> X65454
<400> 9878

gaattcccc  gaggacctg  tgcctctgg  cacggccta  ggccacgct  tggagcagt  60
tgaagggga  agctggcgc  agagcgcgc  ctacctgga  gcggcgctg  ggctgcatc  120
gctgctgcg  gacagtgag  ccttctgcc  cgccaactg  agcggcccc  ccacctcgc  180
gccccggcc  gctcccggc  ccgacggcg  caacgaggg  gatggcgag  attgggcgc  240
cgagctgcg  ctcttcggc  acgtcctgg  gcgtgccgc  tgtttgcgg  gctgcaagc  300
gactctgcc  gccttccaa  tcccctacc  gtcgcggca  ctactgcgc  acttccaga  360
ccgcctgcc  taccagtac  tgcactacg  gcacttcaa  gcgaaccga  tagagaagg  420
ggtggctgc  gcctacacc  tcctccaga  gaaccccaa  cacgagctg  ccgccaagt  480
tctcaacta  tacagggga  tgctggata  cggagatga  tccctcact  atctggagg  540
ccagcccta  gaggctgtg  tccttcagg  tgtgaagct  tacaacagc  gggactttc  600
cagcagcac  gaacacatg  agcgggcct  ggctgatta  atgaccgtc  ttgctcggt  660
tctagctgg  tgtgaaggg  cccacgagc  ggtagactt  aaggacttc  acccagcca  720
agcagatct  ttcgcagaa  ccctgcagt  caaggtgga  tgtgaagcc  atctcaccc  780
caacgtagg  ggcttcttt  tggacaagt  cgtggccac  atgtatcac  acctgcagt  840
tgcctacta  aaattgaac  atgtgcacc  ggctgcccg  agcgctgct  gctacatgc  900
ctttgaccc  aaggacagt  tcatgcagc  gaacctggt  tattaccgc  tccaccggg  960
tcgctgggg  cttgaagag  aggacttcc  gccccggga  gaagctgtg  tctaccaca  1020
ccagacctc  gaacttcgg  agttgctag  cttcacaca  atgtacctt  agtcagatg  1080
tgagatgga  ctggaggag  cggaatcac  tccggagcc  gaaaaacct  tgtctgatg  1140
cgagttcga  ggcgagggc  actatgagg  gggcctcta  gcggactgg  gcaggagcc  1200
gatgccaag  gtgatgagg  tgaggctga  ccagagcct  aactggcct  agacagtga  1260
atggtgcac  cttcaagct  aggacacct  gctgggggc  ggaactatt  attaaaact  1320
aaaatcggg  ttggggatt  agctcagtg  tagagcact  gcctagcaa  cacaaggcc  1380
tgggttcgg  ccctagctc  ggaattc  1407



<210> 9879
<211> 431
<212> PRT
<213> Rattus norvegicus
<308> Q64375
<400> 9879

Met Pro Leu Ala Thr Ala Tyr Gly His Ala Leu Glu Gln Tyr Glu Gly 
  1               5                  10                  15
Glu Ser Trp Arg Glu Ser Ala Arg Tyr Leu Glu Ala Ala Leu Arg Leu 
             20                  25                  30
His Arg Leu Leu Arg Asp Ser Glu Ala Phe Cys His Ala Asn Cys Ser 
         35                  40                  45
Gly Pro Ala Thr Ser Gln Pro Arg Pro Ala Pro Gly Pro Asp Gly Asp 
     50                  55                  60
Asn Glu Gly Asp Gly Glu Asp Trp Ala Arg Glu Leu Arg Leu Phe Gly 
 65                  70                  75                  80
His Val Leu Glu Arg Ala Ala Cys Leu Arg Arg Cys Lys Arg Thr Leu 
                 85                  90                  95
Pro Ala Phe Gln Val Pro Tyr Pro Ser Arg Gln Leu Leu Arg Asp Phe 
             100                105                110
Gln Asn Arg Leu Pro Tyr Gln Tyr Leu His Tyr Ala His Phe Lys Ala 
         115                120                125
Asn Arg Leu Glu Lys Ala Val Ala Ala Ala Tyr Thr Phe Leu Gln Arg 
     130                135                140
Asn Pro Lys His Glu Leu Thr Ala Lys Tyr Leu Asn Tyr Tyr Arg Gly 
 145                150                155                160
Met Leu Asp Ile Gly Asp Glu Ser Leu Thr Asp Leu Glu Ala Gln Pro 
                 165                170                175
Tyr Glu Ala Val Phe Leu Gln Ala Val Lys Leu Tyr Asn Ser Gly Asp 
             180                185                190
Phe Arg Ser Ser Thr Glu His Met Glu Arg Ala Leu Ala Asp Tyr Met 
         195                200                205
Thr Val Phe Ala Arg Cys Leu Ala Gly Cys Glu Gly Ala His Glu Gln 
     210                215                220
Val Asp Phe Lys Asp Phe Tyr Pro Ala Ile Ala Asp Leu Phe Ala Glu 
 225                230                235                240
Ser Leu Gln Cys Lys Val Asp Cys Glu Ala Asn Leu Thr Pro Asn Val 
                 245                250                255
Gly Gly Phe Phe Val Asp Lys Phe Val Ala Thr Met Tyr His Tyr Leu 
             260                265                270
Gln Phe Ala Tyr Tyr Lys Leu Asn Asp Val His Gln Ala Ala Arg Ser 
         275                280                285
Ala Ala Ser Tyr Met Leu Phe Asp Pro Lys Asp Ser Val Met Gln Gln 
     290                295                300
Asn Leu Val Tyr Tyr Arg Phe His Arg Ala Arg Trp Gly Leu Glu Glu 
 305                310                315                320
Glu Asp Phe Gln Pro Arg Glu Glu Ala Val Leu Tyr His Asn Gln Thr 
                 325                330                335
Ser Glu Leu Arg Glu Leu Leu Asp Phe Thr His Met Tyr Leu Gln Ser 
             340                345                350
Asp Asp Glu Met Glu Leu Glu Glu Thr Glu Ser Leu Pro Glu Pro Glu 
         355                360                365
Lys Pro Leu Ser Asp Ala Glu Phe Glu Gly Glu Gly Asp Tyr Glu Glu 
     370                375                380
Gly Leu Tyr Ala Asp Trp Cys Arg Ser Arg Met Pro Arg Val Met Arg 
 385                390                395                400
Met Arg Leu Ser Gln Ser Leu Asn Trp Pro Lys Thr Val Thr Trp Cys 
                 405                410                415
Thr Leu Gln Ala Gln Asp Thr Trp Leu Gly Ala Gly Thr Ile Tyr 
             420                425                430



<210> 9880
<211> 2347
<212> DNA
<213> Homo sapiens
<308> U47621
<400> 9880

gcgcggcgg  catggctcg  gtggcgtgg  ggctgctgt  gttgctgct  ggcagcgcc  60
gggcgcagt  cgagaagta  agcttccgg  gcttcccgc  cgaggacct  atgccgctg  120
ccgcggcgt  cgggcacgc  ctggagcag  acgagggag  gagctggcg  gagagcgcg  180
gctacctgg  ggcggcgct  cggctgcac  ggctcctgc  cgacagcga  gccttctgc  240
acgccaact  cagcggccc  gcgcccgcg  ccaagcccg  tcccgacgg  ggccgcgca  300
acgagtggg  ctgcgagct  cggctcttc  gccgcgtcc  ggagcgagc  gcctgcctg  360
ggcgctgca  gcggacgct  cccgccttc  aggtgccct  cccgccgcg  cagctgctg  420
gtgacttcc  gagccgcct  ccctaccag  acctgcact  cgcgctgtt  aaggctaac  480
ggctggaga  ggcggtggc  gcggcctac  ccttcctcc  gaggaaccc  aagcacgag  540
tgaccgcca  gtatctcaa  tactatcag  ggatgctgg  cgtcgccga  gagtccctc  600
cggacctag  ggcccagcc  tacgaggcc  tgttcctcc  ggctgtgaa  ctctacaac  660
gcggggatt  ccgcagcag  acggaggac  tggagcggg  cttgtcaga  tacctggca  720
tctttgccc  gtgcctggc  ggctgtgaa  gggcccatg  gcaggtgga  ttcaaggac  780
tctacccgg  catagcaga  ctctttgca  agtccctgc  gtgcaaggt  gactgtgag  840
ccaatttga  ccccaatgt  ggtggctac  tcgtggaca  gttcgtggc  accatgtac  900
actacctgc  gtttgccta  tataagttg  atgatgtgc  ccaggctgc  cgcagcgcc  960
ccagctaca  gctcttcga  cccaaggac  gcgtcatgc  gcagaacct  gtgtattac  1020
ggttccacc  ggctcgctg  ggcctggaa  aggaggact  ccagccccg  gaggaggcc  1080
tgctctacc  caaccagac  gccgagctg  gggagctgc  ggagttcac  cacatgtac  1140
tgcagtcag  tgatgagat  gagctggag  agacagaac  gcccctgga  cctgaggat  1200
ccctatctg  cgccgagtt  gagggggag  gtgactacg  ggagggcat  tatgctgac  1260
ggtggcagg  gccggatgc  aagggtgac  aggccgagg  tgagccaga  cctgaactc  1320
catgagaag  ggacacccc  caccgctca  gcttgggaa  cctggtgcc  atggcccca  1380
cctcaccag  ctgggcagc  gcaagaact  tttattaaa  acttaagat  ggccaggtg  1440
ggtggctca  acctgtaat  ccagcattt  gggaggcca  ggtgggtgg  tcacttgag  1500
ccaggagtt  aagaccagc  tggccaaca  gatgagacc  ccgtctcta  taaaataca  1560
aaattagcc  ggtgtggtg  caggcgcct  aaatcccag  tactcaaga  gctgaggca  1620
gagaatcgc  tgaacctgg  aggcaaagg  tgcggtgaa  tgagattgc  ccaccgcac  1680
ccagcctgg  cgacagagc  agactccat  tttaaaaaa  aacaagacg  gccggcacg  1740
tggctcacg  ctgtaatcc  agcactgag  ggccgatca  ttgaggtca  gagttcaag  1800
cctgcctgg  caacatggt  aaaccccat  tctactaaa  aatacaaaa  ttagccagg  1860
atggtggca  acacctgta  tcgtagctg  ggcaggaga  tcgcctgaa  ccaggaggc  1920
gagcttgca  tgagccgag  tcgtgccac  gcactccag  ctgggcgac  gagtgagac  1980
ccatctcaa  aaaaaaaaa  aaaaactta  gatggacac  gctgactgg  cccccatcc  2040
gcctcaccc  tgggtgctg  accccagac  catcctgcc  cttctatgt  tctggacca  2100
aggatggtg  tggcattgc  ggttggcaa  tgggctgat  gggtccgcc  tcctcactg  2160
tgagctcct  acctggaca  tctcctgga  aaggagttt  cagctgctg  ctggagtct  2220
aggccaaat  gcagagggt  ctccagggt  ctgaagagc  ctggactaa  agtctagtg  2280
ttccagggc  ctgaccagt  ggtgctcaa  aaatgtttg  tgttgaatg  aaaaaaaaa  2340
aaaaaaa  2347



<210> 9881
<211> 437
<212> PRT
<213> Homo sapiens
<308> Q92791
<400> 9881

Met Ala Arg Val Ala Trp Gly Leu Leu Trp Leu Leu Leu Gly Ser Ala 
  1               5                  10                  15
Gly Ala Gln Tyr Glu Lys Tyr Ser Phe Arg Gly Phe Pro Pro Glu Asp 
             20                  25                  30
Leu Met Pro Leu Ala Ala Ala Tyr Gly His Ala Leu Glu Gln Tyr Glu 
         35                  40                  45
Gly Glu Ser Trp Arg Glu Ser Ala Arg Tyr Leu Glu Ala Ala Leu Arg 
     50                  55                  60
Leu His Arg Leu Leu Arg Asp Ser Glu Ala Phe Cys His Ala Asn Cys 
 65                  70                  75                  80
Ser Gly Pro Ala Pro Ala Ala Lys Pro Asp Pro Asp Gly Gly Arg Ala 
                 85                  90                  95
Asp Glu Trp Ala Cys Glu Leu Arg Leu Phe Gly Arg Val Leu Glu Arg 
             100                105                110
Ala Ala Cys Leu Arg Arg Cys Lys Arg Thr Leu Pro Ala Phe Gln Val 
         115                120                125
Pro Tyr Pro Pro Arg Gln Leu Leu Arg Asp Phe Gln Ser Arg Leu Pro 
     130                135                140
Tyr Gln Tyr Leu His Tyr Ala Leu Phe Lys Ala Asn Arg Leu Glu Lys 
 145                150                155                160
Ala Val Ala Ala Ala Tyr Thr Phe Leu Gln Arg Asn Pro Lys His Glu 
                 165                170                175
Leu Thr Ala Lys Tyr Leu Asn Tyr Tyr Gln Gly Met Leu Asp Val Ala 
             180                185                190
Asp Glu Ser Leu Thr Asp Leu Glu Ala Gln Pro Tyr Glu Ala Val Phe 
         195                200                205
Leu Arg Ala Val Lys Leu Tyr Asn Ser Gly Asp Phe Arg Ser Ser Thr 
     210                215                220
Glu Asp Met Glu Arg Ala Leu Ser Glu Tyr Leu Ala Val Phe Ala Arg 
 225                230                235                240
Cys Leu Ala Gly Cys Glu Gly Ala His Glu Gln Val Asp Phe Lys Asp 
                 245                250                255
Phe Tyr Pro Ala Ile Ala Asp Leu Phe Ala Glu Ser Leu Gln Cys Lys 
             260                265                270
Val Asp Cys Glu Ala Asn Leu Thr Pro Asn Val Gly Gly Tyr Phe Val 
         275                280                285
Asp Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala Tyr Tyr 
     290                295                300
Lys Leu Asn Asp Val Arg Gln Ala Ala Arg Ser Ala Ala Ser Tyr Met 
 305                310                315                320
Leu Phe Asp Pro Lys Asp Ser Val Met Gln Gln Asn Leu Val Tyr Tyr 
                 325                330                335
Arg Phe His Arg Ala Arg Trp Gly Leu Glu Glu Glu Asp Phe Gln Pro 
             340                345                350
Arg Glu Glu Ala Met Leu Tyr His Asn Gln Thr Ala Glu Leu Arg Glu 
         355                360                365
Leu Leu Glu Phe Thr His Met Tyr Leu Gln Ser Asp Asp Glu Met Glu 
     370                375                380
Leu Glu Glu Thr Glu Pro Pro Leu Glu Pro Glu Asp Ala Leu Ser Asp 
 385                390                395                400
Ala Glu Phe Glu Gly Glu Gly Asp Tyr Glu Glu Gly Met Tyr Ala Asp 
                 405                410                415
Trp Trp Gln Glu Pro Asp Ala Lys Gly Asp Glu Ala Glu Ala Glu Pro 
             420                425                430
Glu Pro Glu Leu Ala 
         435



<210> 9882
<211> 1407
<212> DNA
<213> Rattus norvegicus
<308> X65454
<400> 9882

gaattcccc  gaggacctg  tgcctctgg  cacggccta  ggccacgct  tggagcagt  60
tgaagggga  agctggcgc  agagcgcgc  ctacctgga  gcggcgctg  ggctgcatc  120
gctgctgcg  gacagtgag  ccttctgcc  cgccaactg  agcggcccc  ccacctcgc  180
gccccggcc  gctcccggc  ccgacggcg  caacgaggg  gatggcgag  attgggcgc  240
cgagctgcg  ctcttcggc  acgtcctgg  gcgtgccgc  tgtttgcgg  gctgcaagc  300
gactctgcc  gccttccaa  tcccctacc  gtcgcggca  ctactgcgc  acttccaga  360
ccgcctgcc  taccagtac  tgcactacg  gcacttcaa  gcgaaccga  tagagaagg  420
ggtggctgc  gcctacacc  tcctccaga  gaaccccaa  cacgagctg  ccgccaagt  480
tctcaacta  tacagggga  tgctggata  cggagatga  tccctcact  atctggagg  540
ccagcccta  gaggctgtg  tccttcagg  tgtgaagct  tacaacagc  gggactttc  600
cagcagcac  gaacacatg  agcgggcct  ggctgatta  atgaccgtc  ttgctcggt  660
tctagctgg  tgtgaaggg  cccacgagc  ggtagactt  aaggacttc  acccagcca  720
agcagatct  ttcgcagaa  ccctgcagt  caaggtgga  tgtgaagcc  atctcaccc  780
caacgtagg  ggcttcttt  tggacaagt  cgtggccac  atgtatcac  acctgcagt  840
tgcctacta  aaattgaac  atgtgcacc  ggctgcccg  agcgctgct  gctacatgc  900
ctttgaccc  aaggacagt  tcatgcagc  gaacctggt  tattaccgc  tccaccggg  960
tcgctgggg  cttgaagag  aggacttcc  gccccggga  gaagctgtg  tctaccaca  1020
ccagacctc  gaacttcgg  agttgctag  cttcacaca  atgtacctt  agtcagatg  1080
tgagatgga  ctggaggag  cggaatcac  tccggagcc  gaaaaacct  tgtctgatg  1140
cgagttcga  ggcgagggc  actatgagg  gggcctcta  gcggactgg  gcaggagcc  1200
gatgccaag  gtgatgagg  tgaggctga  ccagagcct  aactggcct  agacagtga  1260
atggtgcac  cttcaagct  aggacacct  gctgggggc  ggaactatt  attaaaact  1320
aaaatcggg  ttggggatt  agctcagtg  tagagcact  gcctagcaa  cacaaggcc  1380
tgggttcgg  ccctagctc  ggaattc  1407



<210> 9883
<211> 431
<212> PRT
<213> Rattus norvegicus
<308> Q64375
<400> 9883

Met Pro Leu Ala Thr Ala Tyr Gly His Ala Leu Glu Gln Tyr Glu Gly 
  1               5                  10                  15
Glu Ser Trp Arg Glu Ser Ala Arg Tyr Leu Glu Ala Ala Leu Arg Leu 
             20                  25                  30
His Arg Leu Leu Arg Asp Ser Glu Ala Phe Cys His Ala Asn Cys Ser 
         35                  40                  45
Gly Pro Ala Thr Ser Gln Pro Arg Pro Ala Pro Gly Pro Asp Gly Asp 
     50                  55                  60
Asn Glu Gly Asp Gly Glu Asp Trp Ala Arg Glu Leu Arg Leu Phe Gly 
 65                  70                  75                  80
His Val Leu Glu Arg Ala Ala Cys Leu Arg Arg Cys Lys Arg Thr Leu 
                 85                  90                  95
Pro Ala Phe Gln Val Pro Tyr Pro Ser Arg Gln Leu Leu Arg Asp Phe 
             100                105                110
Gln Asn Arg Leu Pro Tyr Gln Tyr Leu His Tyr Ala His Phe Lys Ala 
         115                120                125
Asn Arg Leu Glu Lys Ala Val Ala Ala Ala Tyr Thr Phe Leu Gln Arg 
     130                135                140
Asn Pro Lys His Glu Leu Thr Ala Lys Tyr Leu Asn Tyr Tyr Arg Gly 
 145                150                155                160
Met Leu Asp Ile Gly Asp Glu Ser Leu Thr Asp Leu Glu Ala Gln Pro 
                 165                170                175
Tyr Glu Ala Val Phe Leu Gln Ala Val Lys Leu Tyr Asn Ser Gly Asp 
             180                185                190
Phe Arg Ser Ser Thr Glu His Met Glu Arg Ala Leu Ala Asp Tyr Met 
         195                200                205
Thr Val Phe Ala Arg Cys Leu Ala Gly Cys Glu Gly Ala His Glu Gln 
     210                215                220
Val Asp Phe Lys Asp Phe Tyr Pro Ala Ile Ala Asp Leu Phe Ala Glu 
 225                230                235                240
Ser Leu Gln Cys Lys Val Asp Cys Glu Ala Asn Leu Thr Pro Asn Val 
                 245                250                255
Gly Gly Phe Phe Val Asp Lys Phe Val Ala Thr Met Tyr His Tyr Leu 
             260                265                270
Gln Phe Ala Tyr Tyr Lys Leu Asn Asp Val His Gln Ala Ala Arg Ser 
         275                280                285
Ala Ala Ser Tyr Met Leu Phe Asp Pro Lys Asp Ser Val Met Gln Gln 
     290                295                300
Asn Leu Val Tyr Tyr Arg Phe His Arg Ala Arg Trp Gly Leu Glu Glu 
 305                310                315                320
Glu Asp Phe Gln Pro Arg Glu Glu Ala Val Leu Tyr His Asn Gln Thr 
                 325                330                335
Ser Glu Leu Arg Glu Leu Leu Asp Phe Thr His Met Tyr Leu Gln Ser 
             340                345                350
Asp Asp Glu Met Glu Leu Glu Glu Thr Glu Ser Leu Pro Glu Pro Glu 
         355                360                365
Lys Pro Leu Ser Asp Ala Glu Phe Glu Gly Glu Gly Asp Tyr Glu Glu 
     370                375                380
Gly Leu Tyr Ala Asp Trp Cys Arg Ser Arg Met Pro Arg Val Met Arg 
 385                390                395                400
Met Arg Leu Ser Gln Ser Leu Asn Trp Pro Lys Thr Val Thr Trp Cys 
                 405                410                415
Thr Leu Gln Ala Gln Asp Thr Trp Leu Gly Ala Gly Thr Ile Tyr 
             420                425                430



<210> 9884
<211> 2347
<212> DNA
<213> Homo sapiens
<308> U47621
<400> 9884

gcgcggcgg  catggctcg  gtggcgtgg  ggctgctgt  gttgctgct  ggcagcgcc  60
gggcgcagt  cgagaagta  agcttccgg  gcttcccgc  cgaggacct  atgccgctg  120
ccgcggcgt  cgggcacgc  ctggagcag  acgagggag  gagctggcg  gagagcgcg  180
gctacctgg  ggcggcgct  cggctgcac  ggctcctgc  cgacagcga  gccttctgc  240
acgccaact  cagcggccc  gcgcccgcg  ccaagcccg  tcccgacgg  ggccgcgca  300
acgagtggg  ctgcgagct  cggctcttc  gccgcgtcc  ggagcgagc  gcctgcctg  360
ggcgctgca  gcggacgct  cccgccttc  aggtgccct  cccgccgcg  cagctgctg  420
gtgacttcc  gagccgcct  ccctaccag  acctgcact  cgcgctgtt  aaggctaac  480
ggctggaga  ggcggtggc  gcggcctac  ccttcctcc  gaggaaccc  aagcacgag  540
tgaccgcca  gtatctcaa  tactatcag  ggatgctgg  cgtcgccga  gagtccctc  600
cggacctag  ggcccagcc  tacgaggcc  tgttcctcc  ggctgtgaa  ctctacaac  660
gcggggatt  ccgcagcag  acggaggac  tggagcggg  cttgtcaga  tacctggca  720
tctttgccc  gtgcctggc  ggctgtgaa  gggcccatg  gcaggtgga  ttcaaggac  780
tctacccgg  catagcaga  ctctttgca  agtccctgc  gtgcaaggt  gactgtgag  840
ccaatttga  ccccaatgt  ggtggctac  tcgtggaca  gttcgtggc  accatgtac  900
actacctgc  gtttgccta  tataagttg  atgatgtgc  ccaggctgc  cgcagcgcc  960
ccagctaca  gctcttcga  cccaaggac  gcgtcatgc  gcagaacct  gtgtattac  1020
ggttccacc  ggctcgctg  ggcctggaa  aggaggact  ccagccccg  gaggaggcc  1080
tgctctacc  caaccagac  gccgagctg  gggagctgc  ggagttcac  cacatgtac  1140
tgcagtcag  tgatgagat  gagctggag  agacagaac  gcccctgga  cctgaggat  1200
ccctatctg  cgccgagtt  gagggggag  gtgactacg  ggagggcat  tatgctgac  1260
ggtggcagg  gccggatgc  aagggtgac  aggccgagg  tgagccaga  cctgaactc  1320
catgagaag  ggacacccc  caccgctca  gcttgggaa  cctggtgcc  atggcccca  1380
cctcaccag  ctgggcagc  gcaagaact  tttattaaa  acttaagat  ggccaggtg  1440
ggtggctca  acctgtaat  ccagcattt  gggaggcca  ggtgggtgg  tcacttgag  1500
ccaggagtt  aagaccagc  tggccaaca  gatgagacc  ccgtctcta  taaaataca  1560
aaattagcc  ggtgtggtg  caggcgcct  aaatcccag  tactcaaga  gctgaggca  1620
gagaatcgc  tgaacctgg  aggcaaagg  tgcggtgaa  tgagattgc  ccaccgcac  1680
ccagcctgg  cgacagagc  agactccat  tttaaaaaa  aacaagacg  gccggcacg  1740
tggctcacg  ctgtaatcc  agcactgag  ggccgatca  ttgaggtca  gagttcaag  1800
cctgcctgg  caacatggt  aaaccccat  tctactaaa  aatacaaaa  ttagccagg  1860
atggtggca  acacctgta  tcgtagctg  ggcaggaga  tcgcctgaa  ccaggaggc  1920
gagcttgca  tgagccgag  tcgtgccac  gcactccag  ctgggcgac  gagtgagac  1980
ccatctcaa  aaaaaaaaa  aaaaactta  gatggacac  gctgactgg  cccccatcc  2040
gcctcaccc  tgggtgctg  accccagac  catcctgcc  cttctatgt  tctggacca  2100
aggatggtg  tggcattgc  ggttggcaa  tgggctgat  gggtccgcc  tcctcactg  2160
tgagctcct  acctggaca  tctcctgga  aaggagttt  cagctgctg  ctggagtct  2220
aggccaaat  gcagagggt  ctccagggt  ctgaagagc  ctggactaa  agtctagtg  2280
ttccagggc  ctgaccagt  ggtgctcaa  aaatgtttg  tgttgaatg  aaaaaaaaa  2340
aaaaaaa  2347



<210> 9885
<211> 437
<212> PRT
<213> Homo sapiens
<308> Q92791
<400> 9885

Met Ala Arg Val Ala Trp Gly Leu Leu Trp Leu Leu Leu Gly Ser Ala 
  1               5                  10                  15
Gly Ala Gln Tyr Glu Lys Tyr Ser Phe Arg Gly Phe Pro Pro Glu Asp 
             20                  25                  30
Leu Met Pro Leu Ala Ala Ala Tyr Gly His Ala Leu Glu Gln Tyr Glu 
         35                  40                  45
Gly Glu Ser Trp Arg Glu Ser Ala Arg Tyr Leu Glu Ala Ala Leu Arg 
     50                  55                  60
Leu His Arg Leu Leu Arg Asp Ser Glu Ala Phe Cys His Ala Asn Cys 
 65                  70                  75                  80
Ser Gly Pro Ala Pro Ala Ala Lys Pro Asp Pro Asp Gly Gly Arg Ala 
                 85                  90                  95
Asp Glu Trp Ala Cys Glu Leu Arg Leu Phe Gly Arg Val Leu Glu Arg 
             100                105                110
Ala Ala Cys Leu Arg Arg Cys Lys Arg Thr Leu Pro Ala Phe Gln Val 
         115                120                125
Pro Tyr Pro Pro Arg Gln Leu Leu Arg Asp Phe Gln Ser Arg Leu Pro 
     130                135                140
Tyr Gln Tyr Leu His Tyr Ala Leu Phe Lys Ala Asn Arg Leu Glu Lys 
 145                150                155                160
Ala Val Ala Ala Ala Tyr Thr Phe Leu Gln Arg Asn Pro Lys His Glu 
                 165                170                175
Leu Thr Ala Lys Tyr Leu Asn Tyr Tyr Gln Gly Met Leu Asp Val Ala 
             180                185                190
Asp Glu Ser Leu Thr Asp Leu Glu Ala Gln Pro Tyr Glu Ala Val Phe 
         195                200                205
Leu Arg Ala Val Lys Leu Tyr Asn Ser Gly Asp Phe Arg Ser Ser Thr 
     210                215                220
Glu Asp Met Glu Arg Ala Leu Ser Glu Tyr Leu Ala Val Phe Ala Arg 
 225                230                235                240
Cys Leu Ala Gly Cys Glu Gly Ala His Glu Gln Val Asp Phe Lys Asp 
                 245                250                255
Phe Tyr Pro Ala Ile Ala Asp Leu Phe Ala Glu Ser Leu Gln Cys Lys 
             260                265                270
Val Asp Cys Glu Ala Asn Leu Thr Pro Asn Val Gly Gly Tyr Phe Val 
         275                280                285
Asp Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala Tyr Tyr 
     290                295                300
Lys Leu Asn Asp Val Arg Gln Ala Ala Arg Ser Ala Ala Ser Tyr Met 
 305                310                315                320
Leu Phe Asp Pro Lys Asp Ser Val Met Gln Gln Asn Leu Val Tyr Tyr 
                 325                330                335
Arg Phe His Arg Ala Arg Trp Gly Leu Glu Glu Glu Asp Phe Gln Pro 
             340                345                350
Arg Glu Glu Ala Met Leu Tyr His Asn Gln Thr Ala Glu Leu Arg Glu 
         355                360                365
Leu Leu Glu Phe Thr His Met Tyr Leu Gln Ser Asp Asp Glu Met Glu 
     370                375                380
Leu Glu Glu Thr Glu Pro Pro Leu Glu Pro Glu Asp Ala Leu Ser Asp 
 385                390                395                400
Ala Glu Phe Glu Gly Glu Gly Asp Tyr Glu Glu Gly Met Tyr Ala Asp 
                 405                410                415
Trp Trp Gln Glu Pro Asp Ala Lys Gly Asp Glu Ala Glu Ala Glu Pro 
             420                425                430
Glu Pro Glu Leu Ala 
         435



<210> 9886
<211> 1407
<212> DNA
<213> Rattus norvegicus
<308> X65454
<400> 9886

gaattcccc  gaggacctg  tgcctctgg  cacggccta  ggccacgct  tggagcagt  60
tgaagggga  agctggcgc  agagcgcgc  ctacctgga  gcggcgctg  ggctgcatc  120
gctgctgcg  gacagtgag  ccttctgcc  cgccaactg  agcggcccc  ccacctcgc  180
gccccggcc  gctcccggc  ccgacggcg  caacgaggg  gatggcgag  attgggcgc  240
cgagctgcg  ctcttcggc  acgtcctgg  gcgtgccgc  tgtttgcgg  gctgcaagc  300
gactctgcc  gccttccaa  tcccctacc  gtcgcggca  ctactgcgc  acttccaga  360
ccgcctgcc  taccagtac  tgcactacg  gcacttcaa  gcgaaccga  tagagaagg  420
ggtggctgc  gcctacacc  tcctccaga  gaaccccaa  cacgagctg  ccgccaagt  480
tctcaacta  tacagggga  tgctggata  cggagatga  tccctcact  atctggagg  540
ccagcccta  gaggctgtg  tccttcagg  tgtgaagct  tacaacagc  gggactttc  600
cagcagcac  gaacacatg  agcgggcct  ggctgatta  atgaccgtc  ttgctcggt  660
tctagctgg  tgtgaaggg  cccacgagc  ggtagactt  aaggacttc  acccagcca  720
agcagatct  ttcgcagaa  ccctgcagt  caaggtgga  tgtgaagcc  atctcaccc  780
caacgtagg  ggcttcttt  tggacaagt  cgtggccac  atgtatcac  acctgcagt  840
tgcctacta  aaattgaac  atgtgcacc  ggctgcccg  agcgctgct  gctacatgc  900
ctttgaccc  aaggacagt  tcatgcagc  gaacctggt  tattaccgc  tccaccggg  960
tcgctgggg  cttgaagag  aggacttcc  gccccggga  gaagctgtg  tctaccaca  1020
ccagacctc  gaacttcgg  agttgctag  cttcacaca  atgtacctt  agtcagatg  1080
tgagatgga  ctggaggag  cggaatcac  tccggagcc  gaaaaacct  tgtctgatg  1140
cgagttcga  ggcgagggc  actatgagg  gggcctcta  gcggactgg  gcaggagcc  1200
gatgccaag  gtgatgagg  tgaggctga  ccagagcct  aactggcct  agacagtga  1260
atggtgcac  cttcaagct  aggacacct  gctgggggc  ggaactatt  attaaaact  1320
aaaatcggg  ttggggatt  agctcagtg  tagagcact  gcctagcaa  cacaaggcc  1380
tgggttcgg  ccctagctc  ggaattc  1407



<210> 9887
<211> 431
<212> PRT
<213> Rattus norvegicus
<308> Q64375
<400> 9887

Met Pro Leu Ala Thr Ala Tyr Gly His Ala Leu Glu Gln Tyr Glu Gly 
  1               5                  10                  15
Glu Ser Trp Arg Glu Ser Ala Arg Tyr Leu Glu Ala Ala Leu Arg Leu 
             20                  25                  30
His Arg Leu Leu Arg Asp Ser Glu Ala Phe Cys His Ala Asn Cys Ser 
         35                  40                  45
Gly Pro Ala Thr Ser Gln Pro Arg Pro Ala Pro Gly Pro Asp Gly Asp 
     50                  55                  60
Asn Glu Gly Asp Gly Glu Asp Trp Ala Arg Glu Leu Arg Leu Phe Gly 
 65                  70                  75                  80
His Val Leu Glu Arg Ala Ala Cys Leu Arg Arg Cys Lys Arg Thr Leu 
                 85                  90                  95
Pro Ala Phe Gln Val Pro Tyr Pro Ser Arg Gln Leu Leu Arg Asp Phe 
             100                105                110
Gln Asn Arg Leu Pro Tyr Gln Tyr Leu His Tyr Ala His Phe Lys Ala 
         115                120                125
Asn Arg Leu Glu Lys Ala Val Ala Ala Ala Tyr Thr Phe Leu Gln Arg 
     130                135                140
Asn Pro Lys His Glu Leu Thr Ala Lys Tyr Leu Asn Tyr Tyr Arg Gly 
 145                150                155                160
Met Leu Asp Ile Gly Asp Glu Ser Leu Thr Asp Leu Glu Ala Gln Pro 
                 165                170                175
Tyr Glu Ala Val Phe Leu Gln Ala Val Lys Leu Tyr Asn Ser Gly Asp 
             180                185                190
Phe Arg Ser Ser Thr Glu His Met Glu Arg Ala Leu Ala Asp Tyr Met 
         195                200                205
Thr Val Phe Ala Arg Cys Leu Ala Gly Cys Glu Gly Ala His Glu Gln 
     210                215                220
Val Asp Phe Lys Asp Phe Tyr Pro Ala Ile Ala Asp Leu Phe Ala Glu 
 225                230                235                240
Ser Leu Gln Cys Lys Val Asp Cys Glu Ala Asn Leu Thr Pro Asn Val 
                 245                250                255
Gly Gly Phe Phe Val Asp Lys Phe Val Ala Thr Met Tyr His Tyr Leu 
             260                265                270
Gln Phe Ala Tyr Tyr Lys Leu Asn Asp Val His Gln Ala Ala Arg Ser 
         275                280                285
Ala Ala Ser Tyr Met Leu Phe Asp Pro Lys Asp Ser Val Met Gln Gln 
     290                295                300
Asn Leu Val Tyr Tyr Arg Phe His Arg Ala Arg Trp Gly Leu Glu Glu 
 305                310                315                320
Glu Asp Phe Gln Pro Arg Glu Glu Ala Val Leu Tyr His Asn Gln Thr 
                 325                330                335
Ser Glu Leu Arg Glu Leu Leu Asp Phe Thr His Met Tyr Leu Gln Ser 
             340                345                350
Asp Asp Glu Met Glu Leu Glu Glu Thr Glu Ser Leu Pro Glu Pro Glu 
         355                360                365
Lys Pro Leu Ser Asp Ala Glu Phe Glu Gly Glu Gly Asp Tyr Glu Glu 
     370                375                380
Gly Leu Tyr Ala Asp Trp Cys Arg Ser Arg Met Pro Arg Val Met Arg 
 385                390                395                400
Met Arg Leu Ser Gln Ser Leu Asn Trp Pro Lys Thr Val Thr Trp Cys 
                 405                410                415
Thr Leu Gln Ala Gln Asp Thr Trp Leu Gly Ala Gly Thr Ile Tyr 
             420                425                430



<210> 9888
<211> 2347
<212> DNA
<213> Homo sapiens
<308> U47621
<400> 9888

gcgcggcgg  catggctcg  gtggcgtgg  ggctgctgt  gttgctgct  ggcagcgcc  60
gggcgcagt  cgagaagta  agcttccgg  gcttcccgc  cgaggacct  atgccgctg  120
ccgcggcgt  cgggcacgc  ctggagcag  acgagggag  gagctggcg  gagagcgcg  180
gctacctgg  ggcggcgct  cggctgcac  ggctcctgc  cgacagcga  gccttctgc  240
acgccaact  cagcggccc  gcgcccgcg  ccaagcccg  tcccgacgg  ggccgcgca  300
acgagtggg  ctgcgagct  cggctcttc  gccgcgtcc  ggagcgagc  gcctgcctg  360
ggcgctgca  gcggacgct  cccgccttc  aggtgccct  cccgccgcg  cagctgctg  420
gtgacttcc  gagccgcct  ccctaccag  acctgcact  cgcgctgtt  aaggctaac  480
ggctggaga  ggcggtggc  gcggcctac  ccttcctcc  gaggaaccc  aagcacgag  540
tgaccgcca  gtatctcaa  tactatcag  ggatgctgg  cgtcgccga  gagtccctc  600
cggacctag  ggcccagcc  tacgaggcc  tgttcctcc  ggctgtgaa  ctctacaac  660
gcggggatt  ccgcagcag  acggaggac  tggagcggg  cttgtcaga  tacctggca  720
tctttgccc  gtgcctggc  ggctgtgaa  gggcccatg  gcaggtgga  ttcaaggac  780
tctacccgg  catagcaga  ctctttgca  agtccctgc  gtgcaaggt  gactgtgag  840
ccaatttga  ccccaatgt  ggtggctac  tcgtggaca  gttcgtggc  accatgtac  900
actacctgc  gtttgccta  tataagttg  atgatgtgc  ccaggctgc  cgcagcgcc  960
ccagctaca  gctcttcga  cccaaggac  gcgtcatgc  gcagaacct  gtgtattac  1020
ggttccacc  ggctcgctg  ggcctggaa  aggaggact  ccagccccg  gaggaggcc  1080
tgctctacc  caaccagac  gccgagctg  gggagctgc  ggagttcac  cacatgtac  1140
tgcagtcag  tgatgagat  gagctggag  agacagaac  gcccctgga  cctgaggat  1200
ccctatctg  cgccgagtt  gagggggag  gtgactacg  ggagggcat  tatgctgac  1260
ggtggcagg  gccggatgc  aagggtgac  aggccgagg  tgagccaga  cctgaactc  1320
catgagaag  ggacacccc  caccgctca  gcttgggaa  cctggtgcc  atggcccca  1380
cctcaccag  ctgggcagc  gcaagaact  tttattaaa  acttaagat  ggccaggtg  1440
ggtggctca  acctgtaat  ccagcattt  gggaggcca  ggtgggtgg  tcacttgag  1500
ccaggagtt  aagaccagc  tggccaaca  gatgagacc  ccgtctcta  taaaataca  1560
aaattagcc  ggtgtggtg  caggcgcct  aaatcccag  tactcaaga  gctgaggca  1620
gagaatcgc  tgaacctgg  aggcaaagg  tgcggtgaa  tgagattgc  ccaccgcac  1680
ccagcctgg  cgacagagc  agactccat  tttaaaaaa  aacaagacg  gccggcacg  1740
tggctcacg  ctgtaatcc  agcactgag  ggccgatca  ttgaggtca  gagttcaag  1800
cctgcctgg  caacatggt  aaaccccat  tctactaaa  aatacaaaa  ttagccagg  1860
atggtggca  acacctgta  tcgtagctg  ggcaggaga  tcgcctgaa  ccaggaggc  1920
gagcttgca  tgagccgag  tcgtgccac  gcactccag  ctgggcgac  gagtgagac  1980
ccatctcaa  aaaaaaaaa  aaaaactta  gatggacac  gctgactgg  cccccatcc  2040
gcctcaccc  tgggtgctg  accccagac  catcctgcc  cttctatgt  tctggacca  2100
aggatggtg  tggcattgc  ggttggcaa  tgggctgat  gggtccgcc  tcctcactg  2160
tgagctcct  acctggaca  tctcctgga  aaggagttt  cagctgctg  ctggagtct  2220
aggccaaat  gcagagggt  ctccagggt  ctgaagagc  ctggactaa  agtctagtg  2280
ttccagggc  ctgaccagt  ggtgctcaa  aaatgtttg  tgttgaatg  aaaaaaaaa  2340
aaaaaaa  2347



<210> 9889
<211> 437
<212> PRT
<213> Homo sapiens
<308> Q92791
<400> 9889

Met Ala Arg Val Ala Trp Gly Leu Leu Trp Leu Leu Leu Gly Ser Ala 
  1               5                  10                  15
Gly Ala Gln Tyr Glu Lys Tyr Ser Phe Arg Gly Phe Pro Pro Glu Asp 
             20                  25                  30
Leu Met Pro Leu Ala Ala Ala Tyr Gly His Ala Leu Glu Gln Tyr Glu 
         35                  40                  45
Gly Glu Ser Trp Arg Glu Ser Ala Arg Tyr Leu Glu Ala Ala Leu Arg 
     50                  55                  60
Leu His Arg Leu Leu Arg Asp Ser Glu Ala Phe Cys His Ala Asn Cys 
 65                  70                  75                  80
Ser Gly Pro Ala Pro Ala Ala Lys Pro Asp Pro Asp Gly Gly Arg Ala 
                 85                  90                  95
Asp Glu Trp Ala Cys Glu Leu Arg Leu Phe Gly Arg Val Leu Glu Arg 
             100                105                110
Ala Ala Cys Leu Arg Arg Cys Lys Arg Thr Leu Pro Ala Phe Gln Val 
         115                120                125
Pro Tyr Pro Pro Arg Gln Leu Leu Arg Asp Phe Gln Ser Arg Leu Pro 
     130                135                140
Tyr Gln Tyr Leu His Tyr Ala Leu Phe Lys Ala Asn Arg Leu Glu Lys 
 145                150                155                160
Ala Val Ala Ala Ala Tyr Thr Phe Leu Gln Arg Asn Pro Lys His Glu 
                 165                170                175
Leu Thr Ala Lys Tyr Leu Asn Tyr Tyr Gln Gly Met Leu Asp Val Ala 
             180                185                190
Asp Glu Ser Leu Thr Asp Leu Glu Ala Gln Pro Tyr Glu Ala Val Phe 
         195                200                205
Leu Arg Ala Val Lys Leu Tyr Asn Ser Gly Asp Phe Arg Ser Ser Thr 
     210                215                220
Glu Asp Met Glu Arg Ala Leu Ser Glu Tyr Leu Ala Val Phe Ala Arg 
 225                230                235                240
Cys Leu Ala Gly Cys Glu Gly Ala His Glu Gln Val Asp Phe Lys Asp 
                 245                250                255
Phe Tyr Pro Ala Ile Ala Asp Leu Phe Ala Glu Ser Leu Gln Cys Lys 
             260                265                270
Val Asp Cys Glu Ala Asn Leu Thr Pro Asn Val Gly Gly Tyr Phe Val 
         275                280                285
Asp Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala Tyr Tyr 
     290                295                300
Lys Leu Asn Asp Val Arg Gln Ala Ala Arg Ser Ala Ala Ser Tyr Met 
 305                310                315                320
Leu Phe Asp Pro Lys Asp Ser Val Met Gln Gln Asn Leu Val Tyr Tyr 
                 325                330                335
Arg Phe His Arg Ala Arg Trp Gly Leu Glu Glu Glu Asp Phe Gln Pro 
             340                345                350
Arg Glu Glu Ala Met Leu Tyr His Asn Gln Thr Ala Glu Leu Arg Glu 
         355                360                365
Leu Leu Glu Phe Thr His Met Tyr Leu Gln Ser Asp Asp Glu Met Glu 
     370                375                380
Leu Glu Glu Thr Glu Pro Pro Leu Glu Pro Glu Asp Ala Leu Ser Asp 
 385                390                395                400
Ala Glu Phe Glu Gly Glu Gly Asp Tyr Glu Glu Gly Met Tyr Ala Asp 
                 405                410                415
Trp Trp Gln Glu Pro Asp Ala Lys Gly Asp Glu Ala Glu Ala Glu Pro 
             420                425                430
Glu Pro Glu Leu Ala 
         435



<210> 9890
<211> 1227
<212> DNA
<213> Rattus norvegicus
<308> X65948
<400> 9890

cgcggccgc  ttgaagatg  cgtcgacca  ccgtttgga  gctctccca  gagtcacat  60
tcccaatca  ccagatgcg  ttttagttg  ggactacag  gctggcgac  tgatctgtc  120
cgaatgcgg  ctagttgta  gggaccggg  tattgatgt  gggtctgaa  ggagaactt  180
cagcaatga  aaagcaacg  aagacccat  tcgagttgg  gactctcag  atcctcttc  240
gagtgatgg  gatttgtcc  ccatgattg  caagggtac  ggagcggca  gttttgatg  300
atttggcaa  tctaagtat  agaaccgga  aacaatgag  agctctgat  gagctatga  360
gaacgcatt  aaggagatc  cgaccatgg  agacagaat  aacctccca  gcaatatag  420
tgatcgaac  aataattta  tcaagcaag  atatgagca  aagagcctg  agggaagag  480
taatgatgc  atagcttct  cttgtctgt  catcgcttg  agacaagaa  gcgttccca  540
gacatttaa  gaaatatgt  ctgtgtctc  aatctctaa  aaagaaatt  gccgttgtt  600
taaactgat  ttgaaagct  tggagacga  cgtggatct  atcacaact  gggacttca  660
gtccaggtt  tgctccaac  tttgcctcc  caagcaagt  cagatggca  ctacacaca  720
agcccgcaa  gctgtggag  tggacttgg  tcctggcag  agtcctatc  ctgtggcgg  780
agcagctat  tacatggcc  cccaggctt  agctgagaa  cgaacacag  aagaaatcg  840
ggatattgc  ggtgttgct  atgttacaa  ccgacagtc  tacagactg  tctaccctc  900
ggctccaga  ctcttccct  cagacttca  gtttgacac  ccagtggac  aattacccc  960
gctataagc  gaggcaact  agtgtcaca  tcttaatgt  catggaact  tgtgcatag  1020
cacacagtg  tggttgagc  tttaatgag  aaaaaggag  tggtacgca  tccacagct  1080
agtattatt  cttagtctt  tgtatgtat  tagtagtgc  acatattta  tgacttaaa  1140
ttcttactg  ttctgcttt  ttttttagt  atctaggaa  cagtatttt  gaagatatt  1200
aaatatgta  ttctcaaat  aaatttt  1227



<210> 9891
<211> 316
<212> PRT
<213> Rattus norvegicus
<308> P29053
<400> 9891

Met Ala Ser Thr Ser Arg Leu Asp Ala Leu Pro Arg Val Thr Cys Pro 
  1               5                  10                  15
Asn His Pro Asp Ala Ile Leu Val Glu Asp Tyr Arg Ala Gly Asp Met 
             20                  25                  30
Ile Cys Pro Glu Cys Gly Leu Val Val Gly Asp Arg Val Ile Asp Val 
         35                  40                  45
Gly Ser Glu Trp Arg Thr Phe Ser Asn Asp Lys Ala Thr Lys Asp Pro 
     50                  55                  60
Ser Arg Val Gly Asp Ser Gln Asn Pro Leu Leu Ser Asp Gly Asp Leu 
 65                  70                  75                  80
Ser Thr Met Ile Gly Lys Gly Thr Gly Ala Ala Ser Phe Asp Glu Phe 
                 85                  90                  95
Gly Asn Ser Lys Tyr Gln Asn Arg Arg Thr Met Ser Ser Ser Asp Arg 
             100                105                110
Ala Met Met Asn Ala Phe Lys Glu Ile Thr Thr Met Ala Asp Arg Ile 
         115                120                125
Asn Leu Pro Arg Asn Ile Val Asp Arg Thr Asn Asn Leu Phe Lys Gln 
     130                135                140
Val Tyr Glu Gln Lys Ser Leu Lys Gly Arg Ala Asn Asp Ala Ile Ala 
 145                150                155                160
Ser Ala Cys Leu Tyr Ile Ala Cys Arg Gln Glu Gly Val Pro Arg Thr 
                 165                170                175
Phe Lys Glu Ile Cys Ala Val Ser Arg Ile Ser Lys Lys Glu Ile Gly 
             180                185                190
Arg Cys Phe Lys Leu Ile Leu Lys Ala Leu Glu Thr Ser Val Asp Leu 
         195                200                205
Ile Thr Thr Gly Asp Phe Met Ser Arg Phe Cys Ser Asn Leu Cys Leu 
     210                215                220
Pro Lys Gln Val Gln Met Ala Ala Thr His Ile Ala Arg Lys Ala Val 
 225                230                235                240
Glu Leu Asp Leu Val Pro Gly Arg Ser Pro Ile Ser Val Ala Ala Ala 
                 245                250                255
Ala Ile Tyr Met Ala Ser Gln Ala Ser Ala Glu Lys Arg Thr Gln Lys 
             260                265                270
Glu Ile Gly Asp Ile Ala Gly Val Ala Asp Val Thr Ile Arg Gln Ser 
         275                280                285
Tyr Arg Leu Ile Tyr Pro Arg Ala Pro Asp Leu Phe Pro Ser Asp Phe 
     290                295                300
Lys Phe Asp Thr Pro Val Asp Lys Leu Pro Gln Leu 
 305                310                315



<210> 9892
<211> 1268
<212> DNA
<213> Homo sapiens
<308> M76766
<400> 9892

tgttgtgtc  tgttgcggg  accgcagtc  ccgtgaaga  ggcgtctac  agccgtttg  60
atgctcttc  aagagtcac  tgtccaaac  atccagatg  gattttagt  gaggactac  120
gagccggtg  tatgatctg  cctgaatgt  gcttggttg  aggtgaccg  gttattgat  180
tgggatctg  atggcgaac  ttcagcaat  acaaagcaa  aaaagatcc  tctcgagtt  240
gagattctc  gaatcctct  ctgagtgat  gagatttgt  taccatgat  ggcaagggc  300
caggagctg  aagttttga  gaatttggc  attctaagt  ccagaatcg  agaacaatg  360
gcagttctg  tcgggcaat  atgaatgca  tcaaagaaa  cactaccat  gcagacaga  420
tcaatctac  tcgaaatat  gttgatcga  caaataatt  attcaagca  gtatatgaa  480
agaagagcc  gaagggaag  gctaatgat  ctatagctt  tgcttgtct  tatattgcc  540
gtagacaag  aggggttcc  aggacattt  aagaaatat  tgccgtatc  cgaatttct  600
agaaagaaa  tggtcggtg  tttaaactt  ttttgaaag  gctagaaac  agtgtggat  660
tgattacaa  tggggactt  atgtccagg  tctgttcca  cctttgtct  cctaaacaa  720
tacagatgg  agctacaca  atagcccgt  aagctgtgg  attggactt  gttcctggg  780
ggagcccca  ctctgtggc  gcggcagct  tttacatgg  ctcacaggc  tcagctgaa  840
agaggaccc  aaaagaaat  ggagatatt  ctggtgttg  tgatgttac  atcagacag  900
cctatagac  gatctatcc  cgagcccca  atctgtttc  tacagactt  aaatttgac  960
ccccagtgg  caaactacc  cagctataa  ttgaggcag  taacgtcaa  ttcttgaat  1020
caaaacttt  cctgttgta  atagcctat  caaaatgct  ggttgagcc  ttcatgagg  1080
aaaacaaaa  acatggtac  cattccagg  ctgaatact  ttgcttggc  ttctgtatg  1140
atatactag  gaaacatat  taatgattt  aatttctta  caaatttct  ttgtagcaa  1200
ctaggaaac  gtattttgg  agatatttg  aattatgta  ttcttgaat  aaacatttt  1260
caaaactc  1268



<210> 9893
<211> 316
<212> PRT
<213> Homo sapiens
<308> Q00403
<400> 9893

Met Ala Ser Thr Ser Arg Leu Asp Ala Leu Pro Arg Val Thr Cys Pro 
  1               5                  10                  15
Asn His Pro Asp Ala Ile Leu Val Glu Asp Tyr Arg Ala Gly Asp Met 
             20                  25                  30
Ile Cys Pro Glu Cys Gly Leu Val Val Gly Asp Arg Val Ile Asp Val 
         35                  40                  45
Gly Ser Glu Trp Arg Thr Phe Ser Asn Asp Lys Ala Thr Lys Asp Pro 
     50                  55                  60
Ser Arg Val Gly Asp Ser Gln Asn Pro Leu Leu Ser Asp Gly Asp Leu 
 65                  70                  75                  80
Ser Thr Met Ile Gly Lys Gly Thr Gly Ala Ala Ser Phe Asp Glu Phe 
                 85                  90                  95
Gly Asn Ser Lys Tyr Gln Asn Arg Arg Thr Met Ser Ser Ser Asp Arg 
             100                105                110
Ala Met Met Asn Ala Phe Lys Glu Ile Thr Thr Met Ala Asp Arg Ile 
         115                120                125
Asn Leu Pro Arg Asn Ile Val Asp Arg Thr Asn Asn Leu Phe Lys Gln 
     130                135                140
Val Tyr Glu Gln Lys Ser Leu Lys Gly Arg Ala Asn Asp Ala Ile Ala 
 145                150                155                160
Ser Ala Cys Leu Tyr Ile Ala Cys Arg Gln Glu Gly Val Pro Arg Thr 
                 165                170                175
Phe Lys Glu Ile Cys Ala Val Ser Arg Ile Ser Lys Lys Glu Ile Gly 
             180                185                190
Arg Cys Phe Lys Leu Ile Leu Lys Ala Leu Glu Thr Ser Val Asp Leu 
         195                200                205
Ile Thr Thr Gly Asp Phe Met Ser Arg Phe Cys Ser Asn Leu Cys Leu 
     210                215                220
Pro Lys Gln Val Gln Met Ala Ala Thr His Ile Ala Arg Lys Ala Val 
 225                230                235                240
Glu Leu Asp Leu Val Pro Gly Arg Ser Pro Ile Ser Val Ala Ala Ala 
                 245                250                255
Ala Ile Tyr Met Ala Ser Gln Ala Ser Ala Glu Lys Arg Thr Gln Lys 
             260                265                270
Glu Ile Gly Asp Ile Ala Gly Val Ala Asp Val Thr Ile Arg Gln Ser 
         275                280                285
Tyr Arg Leu Ile Tyr Pro Arg Ala Pro Asp Leu Phe Pro Thr Asp Phe 
     290                295                300
Lys Phe Asp Thr Pro Val Asp Lys Leu Pro Gln Leu 
 305                310                315



<210> 9894
<211> 3233
<212> DNA
<213> Rattus norvegicus
<308> X66022
<400> 9894

tgggaggac  gacccggca  ggacctgct  ggggcagga  ccggggagc  agatggcca  60
ggtcatccc  agccccctg  ggtggtgcg  gcgtgcgcg  ggcggggga  tcagcgcgg  120
cgagtctgt  tggctgcga  tgcgtgtgt  tgtatgtgt  cggccgctg  gggtggggc  180
ggtggggtg  cagggggct  tcaccgcgt  cgggggtgc  agggtatgt  actgtgggt  240
tctggcaag  atggtgtac  acgcgttgc  cctggacgg  tggagggcg  gggggaggg  300
tctccaagg  tttttaggg  aaaggggtc  tgtcccctc  cagggatgc  agggtttga  360
agagggtaa  tgatttaga  aagatgggg  ctgggtaca  tcgagtcga  cccacgcta  420
ctttgtctt  gggtgtgga  tgtgttgtg  gacttatac  ttgcttttt  ttttgtagc  480
gaatgtgtg  gtatgtata  gatttcttt  attctgcac  acctatctg  gtatttggg  540
ctctaagtg  gtgcacatg  ctggtgaaa  tgcaccatt  atgttccgt  tctctggat  600
gggagctgt  gggataggt  taaatattt  cacgaacag  ggcagaccg  actgtccct  660
tgtttccaa  gggtgtacc  gtgtttgtg  atgtatttt  aatttgggt  tgtttttcc  720
cggagggtg  gaatgtgtg  atgtgtacc  gtataaatc  ctgtgatgt  tttgtattg  780
gtgtttggc  gaagtgtct  tggatgaat  tgtaagcgc  tatgtaaat  attctaggg  840
ccctatctt  tgacaacgt  tgactgttg  gatgagtgt  gtgtggtgt  tttccatgt  900
gtggggctt  gtggataat  ttcctctgg  cacatctgg  gtctctgga  acatggcat  960
catagcctt  gcgaggact  ctaccggga  gccatcgag  actgccgca  ctacaacgc  1020
cgcctgtgt  ccgagcgca  cctgcgcct  cccttcctc  actctcaga  cggcgtggc  1080
cagaacaac  gctacatct  gatggagaa  acccaccgc  ggcctggtt  ggccccagg  1140
cagatctac  cttaccccg  ccgctgttg  aggaagaaa  ggagactca  catcctgga  1200
gaccccagg  tccggccct  cgagtacaa  atcgattgt  aggcacctc  gaagaagga  1260
ggtggcctc  cggaagggc  agtccttga  gctctgctg  gcgctgaga  tggagagaa  1320
aaagtggag  tgaaggagg  ggagaccat  atggactgt  agaaacagc  gttgctgga  1380
tttccgcat  atctcgagg  agaagactt  gaggaagac  ttcccagga  gaagaacag  1440
gccaaagga  aggcgtatg  cattggagg  ctccggaaa  gccaggaca  cgcatcctt  1500
gaggaccga  acaagccgt  cgtctgtga  atctgtggg  agaggtata  gaaccggcc  1560
gggcttagc  accactaca  ccacaccca  ctggctgag  aggaggggg  ggagcacac  1620
gagcgccac  ccctgcctt  ccaccggaa  aacaaccat  aacagtttt  caaagaatt  1680
gcctgggtc  ccgaggcac  gaggaaaca  acagccaag  aagcaccag  tggcactgt  1740
atccccaat  gctactgtg  cttttgcct  gggggctcc  agaagactg  atgtcctga  1800
gacctcatc  cctgtgcgg  ctgcgggcg  tcaggacat  cctcgtgtt  acagttcac  1860
gtgaacatg  ccgcagccg  gcggaccta  cgctggcag  gtatcgaat  caagtcctg  1920
agcctgtgt  gcacctcgg  gaatgacgg  gccagctgg  cgggtctca  cccccagga  1980
cagctgctg  tctgtgacg  ctgcgatcg  ggttaccac  tgtactgcc  gagccctcc  2040
atggcggag  ccccggaag  gagctggag  tgccacctc  gtctccggc  cttgaaaga  2100
aaggcctcc  cttacatca  cctgactta  acctggctc  gcttctcca  gacctttgg  2160
tggtgctat  ctcggcctc  tggagctcc  gacttttcc  gcctggtgt  cccagtgga  2220
gggataggg  gaagcccag  gaggggcca  ggcggtctc  ctctgcaag  ggaatgtta  2280
cctgaggga  ggtgggtcc  gcagggtcc  tcctgtccc  catcttcat  ccttgacaa  2340
tgggcacca  gcttctgct  ccctcaaag  cataccgcc  ctgggcggg  atagagggg  2400
agtggatgc  agccagtgg  acggaaaaa  cctttttct  aagaaaaag  caaaacgtg  2460
aaaaaaaaa  aggaaaaaa  aaaagaaat  aatatatac  aagattcct  taagcctgg  2520
tgggtgggg  gccactgag  gtctgctgg  acctgactt  accagtttc  tgaatggcc  2580
ctccccacc  catttctgg  gttgcaatt  tctcaactc  catctgagg  gggtaccac  2640
ccttcctca  agccaggcc  ggtgggcat  gtgcccaca  actgccccc  cccggtacc  2700
accgtggat  ctgcatgat  tgaaccatg  ttttgaact  ttcctgccc  tcctttgag  2760
gccccgccc  gcgcccacc  ggtgcctgc  agacctggg  cttgcagct  ggggaggcc  2820
gtggggtga  gcaggcagg  aggcagcca  cccgctgca  tgagaagaa  cacagattg  2880
aatggactc  gttgttttt  gttttttgt  tttgttttt  ttttttttt  tttctttct  2940
ccttctcaa  cctttcctt  cctacccag  caggctggg  tgcctcctt  cccccatcg  3000
tagccattt  gggggtggc  aggaggtgt  gtcgtttct  gtggttgtg  gtgtttgtt  3060
ttcgggttt  aaaaaaggg  aattgagac  gcaagtggg  ggaggtgga  ggtctgggg  3120
agtctgccc  ccaacccag  agtaccccc  ttgccacca  gtctccttt  ttgcctgcc  3180
ctgctgtga  ttaacttgt  ctgtgtatt  aactgggcc  gacccctct  ccc  3233



<210> 9895
<211> 397
<212> PRT
<213> Rattus norvegicus
<308> P56163
<400> 9895

Met Ala Thr Val Ile Pro Ser Pro Leu Ser Leu Gly Glu Asp Phe Tyr 
  1               5                  10                  15
Arg Glu Ala Ile Glu His Cys Arg Ser Tyr Asn Ala Arg Leu Cys Ala 
             20                  25                  30
Glu Arg Ser Leu Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val Ala 
         35                  40                  45
Gln Asn Asn Cys Tyr Ile Trp Met Glu Lys Thr His Arg Gly Pro Gly 
     50                  55                  60
Leu Ala Pro Gly Gln Ile Tyr Thr Tyr Pro Ala Arg Cys Trp Arg Lys 
 65                  70                  75                  80
Lys Arg Arg Leu Asn Ile Leu Glu Asp Pro Arg Leu Arg Pro Cys Glu 
                 85                  90                  95
Tyr Lys Ile Asp Cys Glu Ala Pro Leu Lys Lys Glu Gly Gly Leu Pro 
             100                105                110
Glu Gly Pro Val Leu Glu Ala Leu Leu Cys Ala Glu Thr Gly Glu Lys 
         115                120                125
Lys Val Glu Leu Lys Glu Glu Glu Thr Ile Met Asp Cys Gln Lys Gln 
     130                135                140
Gln Leu Leu Glu Phe Pro His Asp Leu Glu Val Glu Asp Leu Glu Glu 
 145                150                155                160
Asp Ile Pro Arg Arg Lys Asn Arg Ala Lys Gly Lys Ala Tyr Gly Ile 
                 165                170                175
Gly Gly Leu Arg Lys Arg Gln Asp Asn Ala Ser Leu Glu Asp Arg Asp 
             180                185                190
Lys Pro Tyr Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys Asn Arg Pro 
         195                200                205
Gly Leu Ser Tyr His Tyr Thr His Thr His Leu Ala Glu Glu Glu Gly 
     210                215                220
Glu Glu His Thr Glu Arg His Ala Leu Pro Phe His Arg Lys Asn Asn 
 225                230                235                240
His Lys Gln Phe Tyr Lys Glu Leu Ala Trp Val Pro Glu Ala Gln Arg 
                 245                250                255
Lys His Thr Ala Lys Lys Ala Pro Asp Gly Thr Val Ile Pro Asn Gly 
             260                265                270
Tyr Cys Asp Phe Cys Leu Gly Gly Ser Lys Lys Thr Gly Cys Pro Glu 
         275                280                285
Asp Leu Ile Ser Cys Ala Asp Cys Gly Arg Ser Gly His Pro Ser Cys 
     290                295                300
Leu Gln Phe Thr Val Asn Met Thr Ala Ala Val Arg Thr Tyr Arg Trp 
 305                310                315                320
Gln Cys Ile Glu Cys Lys Ser Cys Ser Leu Cys Gly Thr Ser Glu Asn 
                 325                330                335
Asp Gly Ala Ser Trp Ala Gly Leu Thr Pro Gln Asp Gln Leu Leu Phe 
             340                345                350
Cys Asp Asp Cys Asp Arg Gly Tyr His Met Tyr Cys Leu Ser Pro Pro 
         355                360                365
Met Ala Glu Pro Pro Glu Gly Ser Trp Ser Cys His Leu Cys Leu Arg 
     370                375                380
His Leu Lys Glu Lys Ala Ser Ala Tyr Ile Thr Leu Thr 
 385                390                395



<210> 9896
<211> 1421
<212> DNA
<213> Homo sapiens
<308> U43843
<400> 9896

agcaagatg  ccacggtca  ccccagccc  ctgagccta  gcgaggact  ctaccgcga  60
gccatcgag  actgccgca  ttacaacgc  cgcctgtgc  ccgagcgca  cctgcgact  120
cccttcctc  actcgcaga  cggcgtggc  cagaacaac  gctacatct  gatggagaa  180
acccaccgc  ggccgggtt  ggccccggg  cagatttac  cgtaccccg  ccgctgttg  240
aggaagaaa  ggagactca  catcctgga  gaccccaga  tcaggccct  cgagtacaa  300
atcgactgt  aagcacccc  gaagaagga  ggtggcctc  cggaagggc  ggtcctcga  360
gctctactg  gtgcagaga  gggggagaa  aagattgag  tgaaggagg  ggagaccat  420
atggactgt  agaaacagc  gttgctgga  tttccgcat  acctcgagg  ggaagactt  480
gaggatgac  ttcccagga  gaagaacag  gccaaagga  aggcatatg  catcggggg  540
ctccggaaa  gccaggaca  cgcttccct  gaggaccga  acaagccgt  tgtctgtga  600
aagttttac  aagaattgg  ctgggtccc  gaggcacaa  ggaaacaca  agccaagaa  660
gcgcccgac  gcactgtca  ccccaacgg  tactgtgac  tctgcctgg  gggctccaa  720
aagacgggg  gtcccgagg  cctcatctc  tgtgcggac  gtgggcgat  aggacaccc  780
tcgtgttta  aattcacgg  gaacatgac  gcagccgtg  ggacctacc  ctggcagtg  840
atcgagtgc  aatcctgca  cctgtgcgg  acctccgag  acgacggtg  cagctgggc  900
ggtctcacc  cccaggacc  gctgctgtt  tgtgatgac  gcgatcggg  ttaccacat  960
tactgcctg  gtcccccca  ggcggagcc  ccggaaggg  gctggagct  tcacctctg  1020
ctccggcac  tgaaggaaa  ggcttctgc  tacatcacc  tcacctagg  cggctcggc  1080
cgccgcgac  ctggggtgg  gctcgccta  ctgcctctc  gagctcctc  attctcccc  1140
accctgaac  tcccgcagg  ggaggggga  agggggaag  cgagagggg  ctgggccac  1200
ccctcccct  tgtgcaagt  gaatgtctg  cctgtgggt  ggtgggccc  gccagggcc  1260
ctccctccc  ccctccctc  ctgtccctt  gcaaatgga  accaggggc  tctcccctc  1320
aagccatac  cctctgggc  ggcatgggg  gtggtgggt  ccagccagg  gcatggaca  1380
agccttttt  taaagaaaa  gacaaaaag  taaaaaaaa  a  1421



<210> 9897
<211> 353
<212> PRT
<213> Homo sapiens
<308> Q92782
<400> 9897

Met Ala Thr Val Ile Pro Ser Pro Leu Ser Leu Gly Glu Asp Phe Tyr 
  1               5                  10                  15
Arg Glu Ala Ile Glu His Cys Arg Ser Tyr Asn Ala Arg Leu Cys Ala 
             20                  25                  30
Glu Arg Ser Leu Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val Ala 
         35                  40                  45
Gln Asn Asn Cys Tyr Ile Trp Met Glu Lys Thr His Arg Gly Pro Gly 
     50                  55                  60
Leu Ala Pro Gly Gln Ile Tyr Thr Tyr Pro Ala Arg Cys Trp Arg Lys 
 65                  70                  75                  80
Lys Arg Arg Leu Asn Ile Leu Glu Asp Pro Arg Leu Arg Pro Cys Glu 
                 85                  90                  95
Tyr Lys Ile Asp Cys Glu Ala Pro Leu Lys Lys Glu Gly Gly Leu Pro 
             100                105                110
Glu Gly Pro Val Leu Glu Ala Leu Leu Cys Ala Glu Thr Gly Glu Lys 
         115                120                125
Lys Ile Glu Leu Lys Glu Glu Glu Thr Ile Met Asp Cys Gln Lys Gln 
     130                135                140
Gln Leu Leu Glu Phe Pro His Asp Leu Glu Val Glu Asp Leu Glu Asp 
 145                150                155                160
Asp Ile Pro Arg Arg Lys Asn Arg Ala Lys Gly Lys Ala Tyr Gly Ile 
                 165                170                175
Gly Gly Leu Arg Lys Arg Gln Asp Thr Ala Ser Leu Glu Asp Arg Asp 
             180                185                190
Lys Pro Tyr Val Cys Asp Lys Phe Tyr Lys Glu Leu Ala Trp Val Pro 
         195                200                205
Glu Ala Gln Arg Lys His Thr Ala Lys Lys Ala Pro Asp Gly Thr Val 
     210                215                220
Ile Pro Asn Gly Tyr Cys Asp Phe Cys Leu Gly Gly Ser Lys Lys Thr 
 225                230                235                240
Gly Cys Pro Glu Asp Leu Ile Ser Cys Ala Asp Cys Gly Arg Ser Gly 
                 245                250                255
His Pro Ser Cys Leu Gln Phe Thr Val Asn Met Thr Ala Ala Val Arg 
             260                265                270
Thr Tyr Arg Trp Gln Cys Ile Glu Cys Lys Ser Cys Ser Leu Cys Gly 
         275                280                285
Thr Ser Glu Asn Asp Gly Ala Ser Trp Ala Gly Leu Thr Pro Gln Asp 
     290                295                300
Gln Leu Leu Phe Cys Asp Asp Cys Asp Arg Gly Tyr His Met Tyr Cys 
 305                310                315                320
Leu Ser Pro Pro Met Ala Glu Pro Pro Glu Gly Ser Trp Ser Cys His 
                 325                330                335
Leu Cys Leu Arg His Leu Lys Glu Lys Ala Ser Ala Tyr Ile Thr Leu 
             340                345                350
Thr 
         355



<210> 9898
<211> 3586
<212> DNA
<213> Rattus norvegicus
<308> X66140
<400> 9898

caagaacaa  gagtagggt  aagcttttc  cagataacc  ttcagaatg  ttcccacag  60
tatattttt  atgagtgtc  ttatttctc  gatgcaagg  agagggatt  ttggagtag  120
gggtcaaga  ctggttcat  ctaaaaagc  atccctgct  cagaaacgg  atcttgaac  180
catccatga  tctgataca  cggaggaat  tgaagaaga  ttgttgtat  aaataaaat  240
ggggagaaa  actttaacc  ttcaccttc  gaaagcaag  gaattcctc  ctctaaatt  300
cagtgaaac  tactacaac  taaagagag  aatggtcac  aggcatcca  agatcttgg  360
tcactgttt  taccaaggc  ccatcatac  tgaatttga  tctgcggca  gcatcagca  420
ttgtaatgg  ctgagaggc  tcttcaggg  aaatgacca  cggtacctc  ttgaaccag  480
aaaatactc  gatgaggga  atcatttgg  gttcaaata  aatgtcaag  caccttatg  540
taccaatta  tcctgtgaa  ggctgaatt  taccaagaa  tctactctg  tagatgcta  600
gattataga  gagcataaa  tagaagact  tcacaaaga  aagttcatt  aattgtttg  660
tgttgctga  gaatttgtg  accgcagga  cagtaaacc  caaaacaag  taagaaaac  720
aatttgggg  atggtcaat  ttgtcaaca  gatttataa  gccttgaac  ttcgtgtga  780
tttgactgg  atggaaata  ggtcggctg  agatgagat  gaaatagtg  ccaatctag  840
aagtacctt  ttgcatttt  cgacttggc  agaaacagt  ctcaaaaag  ggaaggact  900
tgatcatgt  attttactg  gtgggaagt  gctctacac  tctatgcaa  gaattgctt  960
cccaggagg  atatgtcag  cccttcgtt  atgcagtgt  gttaaggat  ttctgccag  1020
tgtaaatat  attggcaac  ggatggcac  tcagctggg  cacagcctg  gcatgcggc  1080
tgatgactt  ccatgcacc  gtcctttgg  gaaatgtgt  atgggtgca  gaagcatcc  1140
tgcaataaa  ttcagcaaa  gcagccaaa  ccaatacca  caatttctg  agaatcaga  1200
accagcatg  atactcaac  acccacttc  ggaagaatt  aatgattat  cgttctgtg  1260
gaacaagaa  gtggatgag  gagaagagt  tgactgtgg  ccagttcag  aatgcacca  1320
tccttgctg  gatgcacac  aatgtgtcc  gaagccagg  ttcacttgt  tagaaggag  1380
gtgctgtga  tcatgtcag  tgaagaagg  aggggttat  tgcagacca  caaagaatg  1440
atgtgatat  tcggaagtg  gtactggct  ctcccctga  tgtcctaaa  acgagtccc  1500
agccaacgg  tttccttgc  agaatggag  aggctactg  tttatgggg  tgtgtccca  1560
tcgggatga  cagtgcgca  agttgttca  tggtggagc  gaagagagt  acagccttt  1620
ctacaggat  aatcaaaag  gaaacagat  tggatactg  aaaaataag  acaacacgt  1680
tgttccctg  gaagagaaa  atctcaaat  tggaaagat  tactgcacc  gaggccggc  1740
ttcagcaca  cttggagag  ataaaacct  taaccttaa  aatgtgaag  agaatatct  1800
catcaaatg  aaaaccatg  ttttatacc  caattctag  gacatgggc  tggtgaatt  1860
tggaacaaa  tgtggtgag  gaatggttt  cagcaatgg  gaatgtata  aaatggaga  1920
ggcctacaa  tcaaccatc  gctcttccc  gtgtgatga  aatgatgtg  atgacaatg  1980
acctgactg  cagtgtgaa  aaggaccaa  aattacaga  tggggagaa  ccttaaacc  2040
taccagtgt  tccatcatg  tcgttgtgc  tgtcatggt  attattggt  ttggacttg  2100
catattact  atccgttac  agaaatgca  taagatgaa  caagttcaa  gctcttcta  2160
agaaatacg  ggcatagag  ataaagtat  ctttcctga  gagcatcag  cgaggagtg  2220
gccaatctt  acagatatc  atcccctac  taatacggc  gagtcattg  aaagagttc  2280
ttccacctt  tcaagtcct  actacatca  cctgaaatc  gtcagcaag  acccaagag  2340
aattgcaga  cctaagcaa  atgataaca  gaatttgaa  ctggatagc  aaagcgact  2400
cacaagact  ggctaaaga  cccccatgc  gatcatcac  gccttggtg  ctgctaaac  2460
gatttcagt  gtttgccaa  tatccctta  ctggataga  aatgttcaa  agaaatagt  2520
tcttcctgt  aatattaag  catagaacc  acaatctat  gcacacaca  aatccccac  2580
aaaaatgaa  atgaaattt  caatgggct  taatttaat  cccaaatag  aagtctctc  2640
gctctagta  tttcctatg  aatattaat  ttgtaattt  ataataatc  aagcttgtg  2700
tcatttaga  tttcacata  aaggaacag  taaggctag  ggttggtta  tttgttaag  2760
tcattttaa  agcacttac  ttcaggtca  atgttgtgg  ccagaccta  aatccctag  2820
ggttgagat  ggaggatca  aggttcagg  tctacatgg  ctgcagaga  agatcatgt  2880
aagtctgga  aacttggtg  gaactcttt  aaaaaaatc  taaaattta  aattgcacc  2940
gaaatgtta  ggaacagct  ttggtggag  agaatggga  acaccctgg  ttcaacccc  3000
agaattaaa  aaacaaaac  aaacaaagc  aacaaacaa  acagaaaga  caaaacaga  3060
gacagtgtg  ctactttga  ttgcaaact  tatcactga  gtctgcttt  aatgaaatt  3120
tcttctatg  aagggccaa  gaggttagg  cagggcaga  agttatagt  gctgattag  3180
agagggagg  acaaaagaa  ggcctccta  actatagca  cagcactgt  acaaagcat  3240
tcatccatt  cccagggtg  agaggcctg  gcaagcttt  ggttcctag  cctgccttt  3300
tagatttct  taataagtc  agaaaatga  agggctttt  aaatattca  tccacttcc  3360
tgtgagtcc  caggaaaca  agatggggg  gtgcttagt  ttcattttc  ttactgcag  3420
acactgcat  cccatggat  tgttgcctt  cgttgggtt  tttccttat  cagatgtct  3480
tgggtggaa  cactctctc  cactgactc  gttttctta  tgggagctg  taagtcttt  3540
aaatctata  ataattttc  cccatcctt  aataaagat  tcaaac  3586



<210> 9899
<211> 789
<212> PRT
<213> Rattus norvegicus
<308> Q63180
<400> 9899

Met Phe Pro Thr Gly Ile Phe Leu Met Ser Val Leu Ile Ser Gln Met 
  1               5                  10                  15
Gln Gly Arg Gly Ile Val Gly Val Glu Gly Gln Glu Leu Val His Pro 
             20                  25                  30
Lys Lys Leu Ser Leu Leu Gln Lys Arg Asp Leu Glu Arg Ile His Asp 
         35                  40                  45
Ser Asp Thr Pro Glu Glu Tyr Glu Glu Glu Leu Leu Tyr Glu Ile Lys 
     50                  55                  60
Leu Gly Arg Lys Thr Leu Thr Leu His Leu Leu Lys Ala Arg Glu Phe 
 65                  70                  75                  80
Leu Ala Leu Asn Tyr Ser Glu Thr Tyr Tyr Asn Ile Lys Arg Glu Met 
                 85                  90                  95
Val Thr Arg His Pro Gln Ile Leu Asp His Cys Phe Tyr Gln Gly Ser 
             100                105                110
Ile Ile His Glu Phe Asp Ser Ala Ala Ser Ile Ser Thr Cys Asn Gly 
         115                120                125
Leu Arg Gly Phe Phe Arg Val Asn Asp Gln Arg Tyr Leu Ile Glu Pro 
     130                135                140
Val Lys Tyr Ser Asp Glu Gly Asp His Leu Val Phe Lys Tyr Asn Val 
 145                150                155                160
Lys Ala Pro Tyr Ala Thr Asn Tyr Ser Cys Glu Gly Leu Asn Phe Thr 
                 165                170                175
Lys Lys Ser Thr Leu Ile Asp Ala Lys Ile Ile Glu Glu His Lys Val 
             180                185                190
Glu Asp Tyr His Lys Glu Lys Phe Ile Glu Leu Phe Val Val Ala Asp 
         195                200                205
Glu Phe Val Tyr Arg Arg Asn Ser Lys Pro Gln Asn Lys Leu Arg Lys 
     210                215                220
Arg Ile Trp Gly Met Val Asn Phe Val Asn Met Ile Tyr Lys Ala Leu 
 225                230                235                240
Asn Ile Arg Val Thr Leu Thr Gly Met Glu Ile Trp Ser Ala Gly Asp 
                 245                250                255
Glu Ile Glu Ile Val Ser Asn Leu Glu Ser Thr Leu Leu His Phe Ser 
             260                265                270
Thr Trp Gln Glu Thr Val Leu Lys Lys Arg Lys Asp Phe Asp His Val 
         275                280                285
Ile Leu Leu Ser Gly Lys Trp Leu Tyr Thr Ser Met Gln Gly Ile Ala 
     290                295                300
Tyr Pro Gly Gly Ile Cys Gln Thr Leu Arg Ser Cys Ser Val Val Lys 
 305                310                315                320
Asp Leu Leu Pro Asp Val Asn Ile Ile Gly Asn Arg Met Ala His Gln 
                 325                330                335
Leu Gly His Ser Leu Gly Met Arg His Asp Asp Phe Pro Cys Thr Cys 
             340                345                350
Pro Leu Gly Lys Cys Val Met Gly Ala Gly Ser Ile Pro Ala Ile Lys 
         355                360                365
Phe Ser Lys Cys Ser Gln Thr Gln Tyr Gln Gln Phe Leu Lys Asn Gln 
     370                375                380
Lys Pro Ala Cys Ile Leu Asn Asn Pro Leu Pro Glu Glu Phe Asn Asp 
 385                390                395                400
Tyr Pro Phe Cys Gly Asn Lys Lys Val Asp Glu Gly Glu Glu Cys Asp 
                 405                410                415
Cys Gly Pro Val Gln Glu Cys Thr Asn Pro Cys Cys Asp Ala His Lys 
             420                425                430
Cys Val Leu Lys Pro Gly Phe Thr Cys Val Glu Gly Glu Cys Cys Glu 
         435                440                445
Ser Cys Gln Met Lys Lys Glu Gly Val Ile Cys Arg Pro Ala Lys Asn 
     450                455                460
Glu Cys Asp Ile Ser Glu Val Cys Thr Gly Tyr Ser Pro Glu Cys Pro 
 465                470                475                480
Lys Asp Glu Ser Gln Ala Asn Gly Phe Pro Cys Lys Asn Gly Glu Gly 
                 485                490                495
Tyr Cys Phe Met Gly Leu Cys Pro Thr Arg Asp Asp Gln Cys Ala Glu 
             500                505                510
Leu Phe Ser Gly Gly Ala Glu Glu Ser His Ser Leu Cys Tyr Arg Met 
         515                520                525
Asn Gln Lys Gly Asn Arg Phe Gly Tyr Cys Lys Asn Lys Asp Asn Thr 
     530                535                540
Phe Val Pro Cys Glu Glu Lys Asp Leu Lys Cys Gly Lys Ile Tyr Cys 
 545                550                555                560
Thr Gly Gly Arg Arg Ser Ala His Leu Gly Glu Asp Lys Thr Tyr Asn 
                 565                570                575
Leu Lys Asn Val Lys Gln Asn Ile Ser Ile Lys Cys Lys Thr Met Phe 
             580                585                590
Leu Tyr His Asn Ser Arg Asp Met Gly Leu Val Asn Ser Gly Thr Lys 
         595                600                605
Cys Gly Glu Gly Met Val Cys Ser Asn Gly Glu Cys Ile Glu Met Glu 
     610                615                620
Lys Ala Tyr Asn Ser Thr Ile Cys Ser Ser Leu Cys Asp Glu Asn Asp 
 625                630                635                640
Val Asp Asp Asn Glu Pro Asp Cys Gln Cys Glu Glu Gly Pro Ile Ile 
                 645                650                655
Thr Glu Trp Gly Glu Ala Leu Asn Leu Thr Ser Val Ser Ile Met Val 
             660                665                670
Val Val Leu Val Met Val Ile Ile Gly Val Gly Leu Val Ile Leu Leu 
         675                680                685
Ile Arg Tyr Gln Lys Cys Ile Lys Met Lys Gln Val Gln Ser Ser Ser 
     690                695                700
Arg Glu Ile Arg Gly Ile Glu Asn Lys Val Tyr Phe Pro Asp Glu His 
 705                710                715                720
Gln Thr Arg Ser Glu Pro Ile Phe Thr Asp Ile Tyr Pro Leu His Asn 
                 725                730                735
Thr Ala Glu Ser Leu Glu Arg Val Pro Ser Thr Phe Ser Ser Pro His 
             740                745                750
Tyr Ile Thr Leu Lys Ser Val Ser Lys Asp Pro Arg Gly Ile Ala Asp 
         755                760                765
Pro Lys Gln Asn Asp Asn Met Asn Leu Asn Leu Asp Ser Gln Ser Asp 
     770                775                780
Cys Thr Arg Leu Gly 
 785



<210> 9900
<211> 2583
<212> DNA
<213> Homo sapiens
<308> AF215824
<400> 9900

gatccctgc  gtggaagtg  ggaggaaga  aggtgaact  cttttctca  gcacttctg  60
tctcctcta  cagaatcac  cagaatgct  cccgggtgt  tattcttga  gattttact  120
attcctcag  ttaaagaaa  gttcatcct  ggagtagag  gtcaacaac  ggttcgtcc  180
aaaaagctt  ctctgatac  gaagcgaga  actggacac  cccatgatg  tgacatact  240
aaaacgtat  aagaagaat  gttgtatga  ataaaacta  atagaaaaa  cttagtcct  300
catcttcta  gatccaggg  gttcctagg  tcaaattac  gtgaaacat  ctactccat  360
aaaggagga  cgttcacca  gcatcctca  atcatggat  attgttttt  ccaaggatc  420
atagtacac  aatatgatt  agctgccag  atcagtacg  gtaatggtc  aaggggatt  480
ttcagaata  acgaccaaa  atacctcat  gaaccagtg  aatactcag  tgagggaga  540
catttggtg  tcaaatata  cctgagggt  ccgtatggt  ccaattatt  ctgtacaga  600
cttaatttt  ccagaaaaa  tgttccagg  gataatgaa  ctgaagaag  ctccaaaat  660
aaaggcatc  atgatgaaa  gtatgttga  ttgttcatt  ttgctgatg  tactgtgta  720
cgcagaaat  gtcatcctc  caataaact  aggaaccga  tttggggaa  ggtcaattt  780
gtcaacatg  tttataaaa  cttaaacat  catgtgacg  tggttggca  tgaaatatg  840
acacatgaa  ataaaatag  actatattc  aatatagaa  ctaccttat  gcgtttttc  900
ttttggcaa  aaaagatcc  taaaacacg  aaggatttt  atcatgttg  attactcag  960
gggaagtgg  tctactcac  tgtgcaagg  atttcttat  cagggggta  gtgcctgcc  1020
tattattcc  ccagtatca  taaggatct  ttacctgac  caaacataa  tgcaaacag  1080
atggcacat  aactggggc  taaccttgg  atgcagcat  acgagttcc  atgcacctg  1140
ccttcagga  aatgcgtga  ggacagtga  ggaagcatt  ctgcactga  attcagtaa  1200
tgcagccaa  accaatacc  ccagtactt  aaggattat  agccaacat  catgctcaa  1260
attccattt  cttacaatt  tcatgattt  caattttgt  gaaacaaga  gttggatga  1320
ggtgaagag  gtgactgtg  ccctgctca  gagtgtact  atccttgct  tgatgcaca  1380
acatgtgta  tgaagccag  atttacttg  gcagaagga  aatgctgtg  atcttgtca  1440
ataaaaaaa  cagggtcca  atgcagacc  gcgaaagat  aatgtgatt  tcctgagat  1500
tgcactggc  actcgcctg  ctgtcctaa  gaccagttc  gggtcaatg  atttccttg  1560
aagaactca  aaggctact  tttcatggg  aaatgtcca  ctcgtgagg  tcagtgctc  1620
gaactattt  atgatgatg  aatagagag  catgatatc  gctacaaga  gaatacaaa  1680
ggaaataaa  ttggatact  caaaaacaa  gaaaacaga  ttcttccct  tgaggagaa  1740
gatgtcaga  gtggaaaga  ctactgcac  ggaggggag  tttcctctc  ccttggaga  1800
gacaagact  atcacctta  ggatcccca  aagaatgct  ctgtcaaat  caaaactat  1860
tttttatac  atgattcta  agacattgg  ctggtggcg  caggaacaa  atgtggaga  1920
ggaatggtg  gcaacaatg  tgaatgtct  aacatggaa  aggtctata  ctcaaccaa  1980
tgcccctct  agtgcaatg  aaatcctgt  gatggccac  gactccagt  ccactgtga  2040
gaaggacag  cacctgtag  ctgtgaaga  accttacat  ttaccaata  caccatctt  2100
gttgttgtg  ttgtcctgg  tattgtcgg  atcggagtt  ttatactat  agttcgtta  2160
cgaaaatgt  tcaagttga  gcaagttca  agcccacct  cagaaaccc  gggagtgga  2220
aacaaagga  actttggtg  tgagcagca  ataaggact  agccaatcc  gccagaaat  2280
catttccta  ataaacctg  aagtaaaga  tcaagagga  tcgcagatc  caatcaaag  2340
gccaagtga  cttgaagtt  gatatccaa  atggccgtg  aagcttagg  tggggattc  2400
ggatgcaac  tctttacaa  cttacctag  tatctgcta  tcacatttt  ggtagtgtt  2460
caaacgttc  ttatccaga  agacaatgt  taagagaaa  aacttattt  tgttaatat  2520
taccggtag  attcacacc  tctatcata  acatatgct  cagaaaaaa  aaaaaaaaa  2580
aaa  2583



<210> 9901
<211> 754
<212> PRT
<213> Homo sapiens
<308> Q9H2U9
<400> 9901

Met Leu Pro Gly Cys Ile Phe Leu Met Ile Leu Leu Ile Pro Gln Val 
  1               5                  10                  15
Lys Glu Lys Phe Ile Leu Gly Val Glu Gly Gln Gln Leu Val Arg Pro 
             20                  25                  30
Lys Lys Leu Pro Leu Ile Gln Lys Arg Asp Thr Gly His Thr His Asp 
         35                  40                  45
Asp Asp Ile Leu Lys Thr Tyr Glu Glu Glu Leu Leu Tyr Glu Ile Lys 
     50                  55                  60
Leu Asn Arg Lys Thr Leu Val Leu His Leu Leu Arg Ser Arg Glu Phe 
 65                  70                  75                  80
Leu Gly Ser Asn Tyr Ser Glu Thr Phe Tyr Ser Met Lys Gly Gly Ala 
                 85                  90                  95
Phe Thr Arg His Pro Gln Ile Met Asp His Cys Phe Tyr Gln Gly Ser 
             100                105                110
Ile Val His Glu Tyr Asp Ser Ala Ala Ser Ile Ser Thr Cys Asn Gly 
         115                120                125
Leu Arg Gly Phe Phe Arg Ile Asn Asp Gln Arg Tyr Leu Ile Glu Pro 
     130                135                140
Val Lys Tyr Ser Asp Glu Gly Glu His Leu Val Phe Lys Tyr Asn Leu 
 145                150                155                160
Arg Val Pro Tyr Gly Ala Asn Tyr Ser Cys Thr Glu Leu Asn Phe Thr 
                 165                170                175
Arg Lys Thr Val Pro Gly Asp Asn Glu Ser Glu Glu Asp Ser Lys Ile 
             180                185                190
Lys Gly Ile His Asp Glu Lys Tyr Val Glu Leu Phe Ile Val Ala Asp 
         195                200                205
Asp Thr Val Tyr Arg Arg Asn Gly His Pro His Asn Lys Leu Arg Asn 
     210                215                220
Arg Ile Trp Gly Met Val Asn Phe Val Asn Met Ile Tyr Lys Thr Leu 
 225                230                235                240
Asn Ile His Val Thr Leu Val Gly Ile Glu Ile Trp Thr His Glu Asp 
                 245                250                255
Lys Ile Glu Leu Tyr Ser Asn Ile Glu Thr Thr Leu Leu Arg Phe Ser 
             260                265                270
Phe Trp Gln Glu Lys Ile Leu Lys Thr Arg Lys Asp Phe Asp His Val 
         275                280                285
Val Leu Leu Ser Gly Lys Trp Leu Tyr Ser His Val Gln Gly Ile Ser 
     290                295                300
Tyr Pro Gly Gly Met Cys Leu Pro Tyr Tyr Ser Thr Ser Ile Ile Lys 
 305                310                315                320
Asp Leu Leu Pro Asp Thr Asn Ile Ile Ala Asn Arg Met Ala His Gln 
                 325                330                335
Leu Gly His Asn Leu Gly Met Gln His Asp Glu Phe Pro Cys Thr Cys 
             340                345                350
Pro Ser Gly Lys Cys Val Met Asp Ser Asp Gly Ser Ile Pro Ala Leu 
         355                360                365
Lys Phe Ser Lys Cys Ser Gln Asn Gln Tyr His Gln Tyr Leu Lys Asp 
     370                375                380
Tyr Lys Pro Thr Cys Met Leu Asn Ile Pro Phe Pro Tyr Asn Phe His 
 385                390                395                400
Asp Phe Gln Phe Cys Gly Asn Lys Lys Leu Asp Glu Gly Glu Glu Cys 
                 405                410                415
Asp Cys Gly Pro Ala Gln Glu Cys Thr Asn Pro Cys Cys Asp Ala His 
             420                425                430
Thr Cys Val Leu Lys Pro Gly Phe Thr Cys Ala Glu Gly Glu Cys Cys 
         435                440                445
Glu Ser Cys Gln Ile Lys Lys Ala Gly Ser Ile Cys Arg Pro Ala Lys 
     450                455                460
Asp Glu Cys Asp Phe Pro Glu Met Cys Thr Gly His Ser Pro Ala Cys 
 465                470                475                480
Pro Lys Asp Gln Phe Arg Val Asn Gly Phe Pro Cys Lys Asn Ser Glu 
                 485                490                495
Gly Tyr Cys Phe Met Gly Lys Cys Pro Thr Arg Glu Asp Gln Cys Ser 
             500                505                510
Glu Leu Phe Asp Asp Asp Ala Ile Glu Ser His Asp Ile Cys Tyr Lys 
         515                520                525
Met Asn Thr Lys Gly Asn Lys Phe Gly Tyr Cys Lys Asn Lys Glu Asn 
     530                535                540
Arg Phe Leu Pro Cys Glu Glu Lys Asp Val Arg Cys Gly Lys Ile Tyr 
 545                550                555                560
Cys Thr Gly Gly Glu Leu Ser Ser Leu Leu Gly Glu Asp Lys Thr Tyr 
                 565                570                575
His Leu Lys Asp Pro Gln Lys Asn Ala Thr Val Lys Cys Lys Thr Ile 
             580                585                590
Phe Leu Tyr His Asp Ser Thr Asp Ile Gly Leu Val Ala Ser Gly Thr 
         595                600                605
Lys Cys Gly Glu Gly Met Val Cys Asn Asn Gly Glu Cys Leu Asn Met 
     610                615                620
Glu Lys Val Tyr Ile Ser Thr Asn Cys Pro Ser Gln Cys Asn Glu Asn 
 625                630                635                640
Pro Val Asp Gly His Gly Leu Gln Cys His Cys Glu Glu Gly Gln Ala 
                 645                650                655
Pro Val Ala Cys Glu Glu Thr Leu His Val Thr Asn Ile Thr Ile Leu 
             660                665                670
Val Val Val Leu Val Leu Val Ile Val Gly Ile Gly Val Leu Ile Leu 
         675                680                685
Leu Val Arg Tyr Arg Lys Cys Ile Lys Leu Lys Gln Val Gln Ser Pro 
     690                695                700
Pro Thr Glu Thr Leu Gly Val Glu Asn Lys Gly Tyr Phe Gly Asp Glu 
 705                710                715                720
Gln Gln Ile Arg Thr Glu Pro Ile Leu Pro Glu Ile His Phe Leu Asn 
                 725                730                735
Lys Pro Ala Ser Lys Asp Ser Arg Gly Ile Ala Asp Pro Asn Gln Ser 
             740                745                750
Ala Lys 
         755



<210> 9902
<211> 3392
<212> DNA
<213> Rattus norvegicus
<308> X66366
<400> 9902

agaacataa  tcaatccgg  cagcacctc  tctttctgc  ttcacagca  actccaccg  60
atccacgca  acttccata  gaaatccat  tcctgctcc  gccttcccc  acgatatcc  120
cgcctgttt  cgctcggcc  cctccttcc  gctcgcctc  cgctccccg  gcgccctcg  180
tctcgcgct  tccaaggca  gcgcgctcc  ggccggcgc  tccgggctc  gcttctccc  240
gctcctgtc  gtgcggtga  tgcgctggg  aacatggcg  ccgagggaa  gatcctcac  300
aaccacgac  atcaaatcc  tgtcggagt  ctcacagtg  gtgatagct  cttcaggaa  360
cttgcagaa  accgcagtg  gataaatct  aaagatctc  tccaggatc  ttctttgtt  420
ggtgggact  tatcagcat  caagatagt  ccagatgaa  tagaagaaa  caaggaaac  480
ctcatagac  ggtgtgatg  gaaggaact  aatttgata  taacaactg  cggaacagg  540
tttgcacca  gagatgtca  tccagaggc  acaaaagaa  taatagaac  ggaagcgcc  600
gggatggcc  tggcaatgc  gatgggatc  cttaatgtt  cacctctgg  catgctctc  660
agaccagtg  gtggaataa  agggaaaac  ctgataatt  acctgcctg  tagcaagaa  720
ggatctcag  aatgctttc  gttcatact  ccagctcta  ctcatgcca  tgacctttt  780
cgtgatgcc  ttgtaaaag  aaaggaggt  catgatgaa  ttgaagatt  accttcccc  840
ccacctcct  tttctccac  tcctacaac  agcccacat  agcagacag  agacaaagg  900
gttcagtgt  aagaggagg  agaagaaaa  aaagacagt  gtgtagctt  gacagaaga  960
agttcctca  cacatatta  tgcagcagc  cttgctcga  agattccag  ctccatcat  1020
tctcgtggc  ttcaggtgc  cccacgaga  acagcctcc  ttagcacta  tccttcaga  1080
tcgccccgt  cccaggcta  atctcgcct  tctacagct  cttgtccaa  accaaaagt  1140
cagtccagg  gcagcagca  ggagaacat  ctaagagcc  gtcacagtg  tgtagatat  1200
accaaggtg  ctagaagac  tcgcatgtc  ccttttcct  tgacgtcta  ggacaaagc  1260
ttcattaca  ttctggaga  gactccggt  cttggtaca  aaatcatca  ttaccgaga  1320
ggaatgggg  gagtccttg  tcaagatgt  tatgcaaaa  acaacctac  cccattccc  1380
gcatcagta  aagatggct  tgctgttcg  gctgctgat  gtccaggag  tcgtttcat  1440
attggggaa  cccaagctg  tgaacagcc  actcagaca  taatgcccg  acaagtgat  1500
cgggttaca  caggtgctc  aatcccctg  ggtgctgat  cagtagtgc  agttgaaga  1560
actgaactc  tcagggaat  agatgatgg  actgaagaa  ttgaagtgc  aattctggt  1620
caagctcgg  caggccaag  catcagacc  atcggccac  acattaaaa  aggggagtg  1680
gttttggca  aaggaaccc  tatgggccc  tcagaaatt  gtctccttg  aactgtagg  1740
gtcacagaa  ttgaagtta  taagtttcc  gtggttgcc  ttatgtcaa  agggaatga  1800
ctactaaat  ctgaagatg  cctcttacc  ggaaagatt  gggacagca  tcgatcaac  1860
cttctagca  caattcagg  acatggtta  ccaacaatc  acttgggaa  tgtaggaga  1920
aacccagat  acttactca  tgccttgaa  gagggtatc  gccgtgctg  tgtcatcat  1980
acgtcagga  gtgtatcca  gggggaaaa  gactatctc  agcaggtgc  ggacatcga  2040
cttcatgct  agatccatt  tggcagggt  tttatgaag  caggcttgc  aacaacatt  2100
gcaactttg  atattgatg  tgtaagaaa  attattttt  cactaccag  gaatcctgt  2160
tcagctgtg  tcacctgca  cctctttgt  gtacccgca  tgagaaaaa  gcagggtat  2220
ttggatcct  ggccaacca  catcaaagc  aggttatca  gtgacgtaa  gctggaccc  2280
cgcccagaa  accaccggt  tatactgac  tggcatcac  aagaaccac  gccctgggc  2340
cagagtaca  gtaatcaga  gagcagccg  ctgatgagc  tgcgcagtg  caatggatt  2400
ctgatgcta  ctccaaaga  agagcagta  gtggaactt  acaaaggcg  ggtggtgga  2460
gtcatggtc  tcggacggc  atgatggtg  ccaacagga  aaagtttcg  tgcatgtcc  2520
catatcatt  actgtatcc  gtcatatgc  acggcacag  tagtttttc  gatctggat  2580
aaagttgat  tgtatagtc  acatcttga  ctatatttc  aatgaattt  aataccttt  2640
aaagaaaaa  cacacctaa  aataaatct  aacagacaa  tctattctg  ttatatcaa  2700
gcaaaattt  cctttcttg  aaattgctt  gtgtgttca  tgctaggtc  gatagcgat  2760
gctttagta  acagcggta  gtgcctgca  aacttgtgt  tttctcatc  ttaaataca  2820
ctacttatg  tcttaatca  ggctgtctg  ttctttata  tagtgtagg  aacacttgg  2880
tttcccttc  tagtatgct  cataactgc  ttacagaga  cttttgctt  ttctttctc  2940
tgtatctcg  gtttatgtg  accatgcca  aagacgagt  actgcgcgg  ggccccgct  3000
tgcctcaag  gccttccct  ctgagcacc  agggaagct  tcaccctcg  agcctctgg  3060
acacacagt  ctagcaggc  gtaactgga  accttttat  tgaacaaac  aacggggtg  3120
ggggaaatg  ttccttaag  gctgacagc  tttttaacc  acacattta  aattgtaca  3180
aacaaaaat  aaatcaaag  ctgatcttg  acagatatt  gtgttacca  cattcatgt  3240
gaatcaaga  caaaaataa  ataatgtta  acaactctg  accataaca  tttctgtaa  3300
gataatgaa  cttaatgaa  aaaaaaaaa  ccttgatca  tatttaaaa  aaaaaaaaa  3360
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aa  3392



<210> 9903
<211> 736
<212> PRT
<213> Rattus norvegicus
<308> Q03555
<400> 9903

Met Ala Thr Glu Gly Met Ile Leu Thr Asn His Asp His Gln Ile Arg 
  1               5                  10                  15
Val Gly Val Leu Thr Val Ser Asp Ser Cys Phe Arg Asn Leu Ala Glu 
             20                  25                  30
Asp Arg Ser Gly Ile Asn Leu Lys Asp Leu Val Gln Asp Pro Ser Leu 
         35                  40                  45
Leu Gly Gly Thr Ile Ser Ala Tyr Lys Ile Val Pro Asp Glu Ile Glu 
     50                  55                  60
Glu Ile Lys Glu Thr Leu Ile Asp Trp Cys Asp Glu Lys Glu Leu Asn 
 65                  70                  75                  80
Leu Ile Leu Thr Thr Gly Gly Thr Gly Phe Ala Pro Arg Asp Val Thr 
                 85                  90                  95
Pro Glu Ala Thr Lys Glu Val Ile Glu Arg Glu Ala Pro Gly Met Ala 
             100                105                110
Leu Ala Met Leu Met Gly Ser Leu Asn Val Thr Pro Leu Gly Met Leu 
         115                120                125
Ser Arg Pro Val Cys Gly Ile Arg Gly Lys Thr Leu Ile Ile Asn Leu 
     130                135                140
Pro Gly Ser Lys Lys Gly Ser Gln Glu Cys Phe Gln Phe Ile Leu Pro 
 145                150                155                160
Ala Leu Pro His Ala Ile Asp Leu Leu Arg Asp Ala Ile Val Lys Val 
                 165                170                175
Lys Glu Val His Asp Glu Leu Glu Asp Leu Pro Ser Pro Pro Pro Pro 
             180                185                190
Leu Ser Pro Pro Pro Thr Thr Ser Pro His Lys Gln Thr Glu Asp Lys 
         195                200                205
Gly Val Gln Cys Glu Glu Glu Glu Glu Glu Lys Lys Asp Ser Gly Val 
     210                215                220
Ala Ser Thr Glu Asp Ser Ser Ser Ser His Ile Thr Ala Ala Ala Leu 
 225                230                235                240
Ala Arg Lys Ile Pro Asp Ser Ile Ile Ser Arg Gly Val Gln Val Leu 
                 245                250                255
Pro Arg Asp Thr Ala Ser Leu Ser Thr Thr Pro Ser Glu Ser Pro Arg 
             260                265                270
Ala Gln Ala Thr Ser Arg Leu Ser Thr Ala Ser Cys Pro Thr Pro Lys 
         275                280                285
Val Gln Ser Arg Cys Ser Ser Lys Glu Asn Ile Leu Arg Ala Ser His 
     290                295                300
Ser Ala Val Asp Ile Thr Lys Val Ala Arg Arg His Arg Met Ser Pro 
 305                310                315                320
Phe Pro Leu Thr Ser Met Asp Lys Ala Phe Ile Thr Val Leu Glu Met 
                 325                330                335
Thr Pro Val Leu Gly Thr Glu Ile Ile Asn Tyr Arg Asp Gly Met Gly 
             340                345                350
Arg Val Leu Ala Gln Asp Val Tyr Ala Lys Asp Asn Leu Pro Pro Phe 
         355                360                365
Pro Ala Ser Val Lys Asp Gly Tyr Ala Val Arg Ala Ala Asp Gly Pro 
     370                375                380
Gly Asp Arg Phe Ile Ile Gly Glu Ser Gln Ala Gly Glu Gln Pro Thr 
 385                390                395                400
Gln Thr Val Met Pro Gly Gln Val Met Arg Val Thr Thr Gly Ala Pro 
                 405                410                415
Ile Pro Cys Gly Ala Asp Ala Val Val Gln Val Glu Asp Thr Glu Leu 
             420                425                430
Ile Arg Glu Ser Asp Asp Gly Thr Glu Glu Leu Glu Val Arg Ile Leu 
         435                440                445
Val Gln Ala Arg Pro Gly Gln Asp Ile Arg Pro Ile Gly His Asp Ile 
     450                455                460
Lys Arg Gly Glu Cys Val Leu Ala Lys Gly Thr His Met Gly Pro Ser 
 465                470                475                480
Glu Ile Gly Leu Leu Ala Thr Val Gly Val Thr Glu Val Glu Val Asn 
                 485                490                495
Lys Phe Pro Val Val Ala Val Met Ser Thr Gly Asn Glu Leu Leu Asn 
             500                505                510
Pro Glu Asp Asp Leu Leu Pro Gly Lys Ile Arg Asp Ser Asn Arg Ser 
         515                520                525
Thr Leu Leu Ala Thr Ile Gln Glu His Gly Tyr Pro Thr Ile Asn Leu 
     530                535                540
Gly Ile Val Gly Asp Asn Pro Asp Asp Leu Leu Asn Ala Leu Asn Glu 
 545                550                555                560
Gly Ile Ser Arg Ala Asp Val Ile Ile Thr Ser Gly Gly Val Ser Met 
                 565                570                575
Gly Glu Lys Asp Tyr Leu Lys Gln Val Leu Asp Ile Asp Leu His Ala 
             580                585                590
Gln Ile His Phe Gly Arg Val Phe Met Lys Pro Gly Leu Pro Thr Thr 
         595                600                605
Phe Ala Thr Leu Asp Ile Asp Gly Val Arg Lys Ile Ile Phe Ala Leu 
     610                615                620
Pro Gly Asn Pro Val Ser Ala Val Val Thr Cys Asn Leu Phe Val Val 
 625                630                635                640
Pro Ala Leu Arg Lys Met Gln Gly Ile Leu Asp Pro Arg Pro Thr Ile 
                 645                650                655
Ile Lys Ala Arg Leu Ser Cys Asp Val Lys Leu Asp Pro Arg Pro Glu 
             660                665                670
Tyr His Arg Cys Ile Leu Thr Trp His His Gln Glu Pro Leu Pro Trp 
         675                680                685
Ala Gln Ser Thr Gly Asn Gln Met Ser Ser Arg Leu Met Ser Met Arg 
     690                695                700
Ser Ala Asn Gly Leu Leu Met Leu Pro Pro Lys Thr Glu Gln Tyr Val 
 705                710                715                720
Glu Leu His Lys Gly Glu Val Val Asp Val Met Val Ile Gly Arg Leu 
                 725                730                735



<210> 9904
<211> 1727
<212> DNA
<213> Homo sapiens
<308> AK025169
<400> 9904

gtgtgctat  ctttcctct  agtcctgcc  tctagctgc  ttgggtctc  cgctccgca  60
agcgttccg  cactctccg  cctcgttct  ccgcctccg  gcgctctcc  cgtgcggcc  120
ccgcgcccc  caagcttgc  tccttcttg  cggacttgg  gccgcgcgc  ctgactcct  180
cccctcccg  ggacccgcg  actcccggc  cggcctctc  cccacgcag  ccaccgtgc  240
ctctgtggc  tccccctcc  tccccgctc  cctcgcgct  ctctggctc  ctagctgtc  300
cgctctcct  ggcgagcgc  ctcccggcc  gcgcgctcc  ggctccggt  tctcccggc  360
cctgtcagt  cggtgactg  gctgggaaa  atggcgacc  agggaatga  ccttactaa  420
cacgaccat  aaatccgtg  cggagtcct  acagtgagt  atagttgct  caggaatct  480
gcagaagac  gcagtggga  aaatctcaa  gatctcgta  aagatcctt  tttgttggg  540
gggactata  cagcataca  gatagtacc  gatgaaata  aagaaatca  gaaattccc  600
acattccca  tttgtgggc  ccagaaagg  gccacaaaa  aagtaatag  acgggaagc  660
ccagggatg  ccctggcaa  gctgatggg  tcacttaat  ttacacctc  gggcatgct  720
tctaggcct  tatgtggaa  cagagggaa  acgctcatc  ttaacctgc  aggtagcaa  780
aaaggatct  aggaatgct  tcaattcat  ctgccagct  tacctcatg  cattgacct  840
ttacgtgat  ccattgtaa  agtaaagga  gtgcatgat  aacttgaag  tttgccttc  900
ccacctccc  ctctttccc  tcctcctac  accagcccc  ataaacaga  agaagacaa  960
ggagatcaa  gtgaggaag  ggaagaaga  aagaaagac  gtggtgttg  ttcaacaga  1020
gatagttcc  catcacata  aactgcagc  gccattgct  ccaagaagc  tccattcta  1080
accagtcct  ctgttgtca  ggcacacgg  gaacagccc  tccctggtc  catcaatta  1140
tcccatcat  caacagatg  acggattcc  gactccatc  tttctcgtg  tgttcaggt  1200
ctcccacga  acacagcct  cctcagcac  actccttca  aatcgcctc  tgctcaggc  1260
acatctcgc  tctctacag  ttcctgccc  acaccaaaa  tccagtcca  gtgcagcag  1320
aaggagaac  ttctcagag  cagtcacag  gctgtcgat  tcaccaagg  ggctagaag  1380
catcgcatg  ctccttttc  tctgacatc  atggacaaa  cctttatca  agtcctgga  1440
atgactccg  tgcttggga  agaaatcat  aattaccga  gtactatta  atttgacca  1500
tgccctttc  tttcttcat  tttttccaa  taagattca  gtaacatta  tgcacagtt  1560
tcctgaaaa  gaaagatta  taaccatta  tacagttat  atcattctt  ttttttctt  1620
tttctactc  ataagaaaa  ggctaaggg  tcagcctta  cagtataca  ggtaaaatc  1680
atgaaactg  cttttcatt  aaaaaagga  aaaaaaaaa  aaaaaaa  1727



<210> 9905
<211> 736
<212> PRT
<213> Homo sapiens
<308> Q9NQX3
<400> 9905

Met Ala Thr Glu Gly Met Ile Leu Thr Asn His Asp His Gln Ile Arg 
  1               5                  10                  15
Val Gly Val Leu Thr Val Ser Asp Ser Cys Phe Arg Asn Leu Ala Glu 
             20                  25                  30
Asp Arg Ser Gly Ile Asn Leu Lys Asp Leu Val Gln Asp Pro Ser Leu 
         35                  40                  45
Leu Gly Gly Thr Ile Ser Ala Tyr Lys Ile Val Pro Asp Glu Ile Glu 
     50                  55                  60
Glu Ile Lys Glu Thr Leu Ile Asp Trp Cys Asp Glu Lys Glu Leu Asn 
 65                  70                  75                  80
Leu Ile Leu Thr Thr Gly Gly Thr Gly Phe Ala Pro Arg Asp Val Thr 
                 85                  90                  95
Pro Glu Ala Thr Lys Glu Val Ile Glu Arg Glu Ala Pro Gly Met Ala 
             100                105                110
Leu Ala Met Leu Met Gly Ser Leu Asn Val Thr Pro Leu Gly Met Leu 
         115                120                125
Ser Arg Pro Val Cys Gly Ile Arg Gly Lys Thr Leu Ile Ile Asn Leu 
     130                135                140
Pro Gly Ser Lys Lys Gly Ser Gln Glu Cys Phe Gln Phe Ile Leu Pro 
 145                150                155                160
Ala Leu Pro His Ala Ile Asp Leu Leu Arg Asp Ala Ile Val Lys Val 
                 165                170                175
Lys Glu Val His Asp Glu Leu Glu Asp Leu Pro Ser Pro Pro Pro Pro 
             180                185                190
Leu Ser Pro Pro Pro Thr Thr Ser Pro His Lys Gln Thr Glu Asp Lys 
         195                200                205
Gly Val Gln Cys Glu Glu Glu Glu Glu Glu Lys Lys Asp Ser Gly Val 
     210                215                220
Ala Ser Thr Glu Asp Ser Ser Ser Ser His Ile Thr Ala Ala Ala Ile 
 225                230                235                240
Ala Ala Lys Ile Pro Asp Ser Ile Ile Ser Arg Gly Val Gln Val Leu 
                 245                250                255
Pro Arg Asp Thr Ala Ser Leu Ser Thr Thr Pro Ser Glu Ser Pro Arg 
             260                265                270
Ala Gln Ala Thr Ser Arg Leu Ser Thr Ala Ser Cys Pro Thr Pro Lys 
         275                280                285
Val Gln Ser Arg Cys Ser Ser Lys Glu Asn Ile Leu Arg Ala Ser His 
     290                295                300
Ser Ala Val Asp Ile Thr Lys Val Ala Arg Arg His Arg Met Ser Pro 
 305                310                315                320
Phe Pro Leu Thr Ser Met Asp Lys Ala Phe Ile Thr Val Leu Glu Met 
                 325                330                335
Thr Pro Val Leu Gly Thr Glu Ile Ile Asn Tyr Arg Asp Gly Met Gly 
             340                345                350
Arg Val Leu Ala Gln Asp Val Tyr Ala Lys Asp Asn Leu Pro Pro Phe 
         355                360                365
Pro Ala Ser Val Lys Asp Gly Tyr Ala Val Arg Ala Ala Asp Gly Pro 
     370                375                380
Gly Asp Arg Phe Ile Ile Gly Glu Ser Gln Ala Gly Glu Gln Pro Thr 
 385                390                395                400
Gln Thr Val Met Pro Gly Gln Val Met Arg Val Thr Thr Gly Ala Pro 
                 405                410                415
Ile Pro Cys Gly Ala Asp Ala Val Val Gln Val Glu Asp Thr Glu Leu 
             420                425                430
Ile Arg Glu Ser Asp Asp Gly Thr Glu Glu Leu Glu Val Arg Ile Leu 
         435                440                445
Val Gln Ala Arg Pro Gly Gln Asp Ile Arg Pro Ile Gly His Asp Ile 
     450                455                460
Lys Arg Gly Glu Cys Val Leu Ala Lys Gly Thr His Met Gly Pro Ser 
 465                470                475                480
Glu Ile Gly Leu Leu Ala Thr Val Gly Val Thr Glu Val Glu Val Asn 
                 485                490                495
Lys Phe Pro Val Val Ala Val Met Ser Thr Gly Asn Glu Leu Leu Asn 
             500                505                510
Pro Glu Asp Asp Leu Leu Pro Gly Lys Ile Arg Asp Ser Asn Arg Ser 
         515                520                525
Thr Leu Leu Ala Thr Ile Gln Glu His Gly Tyr Pro Thr Ile Asn Leu 
     530                535                540
Gly Ile Val Gly Asp Asn Pro Asp Asp Leu Leu Asn Ala Leu Asn Glu 
 545                550                555                560
Gly Ile Ser Arg Ala Asp Val Ile Ile Thr Ser Gly Gly Val Ser Met 
                 565                570                575
Gly Glu Lys Asp Tyr Leu Lys Gln Val Leu Asp Ile Asp Leu His Ala 
             580                585                590
Gln Ile His Phe Gly Arg Val Phe Met Lys Pro Gly Leu Pro Thr Thr 
         595                600                605
Phe Ala Thr Leu Asp Ile Asp Gly Val Arg Lys Ile Ile Phe Ala Leu 
     610                615                620
Pro Gly Asn Pro Val Ser Ala Val Val Thr Cys Asn Leu Phe Val Val 
 625                630                635                640
Pro Ala Leu Arg Lys Met Gln Gly Ile Leu Asp Pro Arg Pro Thr Ile 
                 645                650                655
Ile Lys Ala Arg Leu Ser Cys Asp Val Lys Leu Asp Pro Arg Pro Glu 
             660                665                670
Tyr His Arg Cys Ile Leu Thr Trp His His Gln Glu Pro Leu Pro Trp 
         675                680                685
Ala Gln Ser Thr Gly Asn Gln Met Ser Ser Arg Leu Met Ser Met Arg 
     690                695                700
Ser Ala Asn Gly Leu Leu Met Leu Pro Pro Lys Thr Glu Gln Tyr Val 
 705                710                715                720
Glu Leu His Lys Gly Glu Val Val Asp Val Met Val Ile Gly Arg Leu 
                 725                730                735



<210> 9906
<211> 3392
<212> DNA
<213> Rattus norvegicus
<308> X66366
<400> 9906

agaacataa  tcaatccgg  cagcacctc  tctttctgc  ttcacagca  actccaccg  60
atccacgca  acttccata  gaaatccat  tcctgctcc  gccttcccc  acgatatcc  120
cgcctgttt  cgctcggcc  cctccttcc  gctcgcctc  cgctccccg  gcgccctcg  180
tctcgcgct  tccaaggca  gcgcgctcc  ggccggcgc  tccgggctc  gcttctccc  240
gctcctgtc  gtgcggtga  tgcgctggg  aacatggcg  ccgagggaa  gatcctcac  300
aaccacgac  atcaaatcc  tgtcggagt  ctcacagtg  gtgatagct  cttcaggaa  360
cttgcagaa  accgcagtg  gataaatct  aaagatctc  tccaggatc  ttctttgtt  420
ggtgggact  tatcagcat  caagatagt  ccagatgaa  tagaagaaa  caaggaaac  480
ctcatagac  ggtgtgatg  gaaggaact  aatttgata  taacaactg  cggaacagg  540
tttgcacca  gagatgtca  tccagaggc  acaaaagaa  taatagaac  ggaagcgcc  600
gggatggcc  tggcaatgc  gatgggatc  cttaatgtt  cacctctgg  catgctctc  660
agaccagtg  gtggaataa  agggaaaac  ctgataatt  acctgcctg  tagcaagaa  720
ggatctcag  aatgctttc  gttcatact  ccagctcta  ctcatgcca  tgacctttt  780
cgtgatgcc  ttgtaaaag  aaaggaggt  catgatgaa  ttgaagatt  accttcccc  840
ccacctcct  tttctccac  tcctacaac  agcccacat  agcagacag  agacaaagg  900
gttcagtgt  aagaggagg  agaagaaaa  aaagacagt  gtgtagctt  gacagaaga  960
agttcctca  cacatatta  tgcagcagc  cttgctcga  agattccag  ctccatcat  1020
tctcgtggc  ttcaggtgc  cccacgaga  acagcctcc  ttagcacta  tccttcaga  1080
tcgccccgt  cccaggcta  atctcgcct  tctacagct  cttgtccaa  accaaaagt  1140
cagtccagg  gcagcagca  ggagaacat  ctaagagcc  gtcacagtg  tgtagatat  1200
accaaggtg  ctagaagac  tcgcatgtc  ccttttcct  tgacgtcta  ggacaaagc  1260
ttcattaca  ttctggaga  gactccggt  cttggtaca  aaatcatca  ttaccgaga  1320
ggaatgggg  gagtccttg  tcaagatgt  tatgcaaaa  acaacctac  cccattccc  1380
gcatcagta  aagatggct  tgctgttcg  gctgctgat  gtccaggag  tcgtttcat  1440
attggggaa  cccaagctg  tgaacagcc  actcagaca  taatgcccg  acaagtgat  1500
cgggttaca  caggtgctc  aatcccctg  ggtgctgat  cagtagtgc  agttgaaga  1560
actgaactc  tcagggaat  agatgatgg  actgaagaa  ttgaagtgc  aattctggt  1620
caagctcgg  caggccaag  catcagacc  atcggccac  acattaaaa  aggggagtg  1680
gttttggca  aaggaaccc  tatgggccc  tcagaaatt  gtctccttg  aactgtagg  1740
gtcacagaa  ttgaagtta  taagtttcc  gtggttgcc  ttatgtcaa  agggaatga  1800
ctactaaat  ctgaagatg  cctcttacc  ggaaagatt  gggacagca  tcgatcaac  1860
cttctagca  caattcagg  acatggtta  ccaacaatc  acttgggaa  tgtaggaga  1920
aacccagat  acttactca  tgccttgaa  gagggtatc  gccgtgctg  tgtcatcat  1980
acgtcagga  gtgtatcca  gggggaaaa  gactatctc  agcaggtgc  ggacatcga  2040
cttcatgct  agatccatt  tggcagggt  tttatgaag  caggcttgc  aacaacatt  2100
gcaactttg  atattgatg  tgtaagaaa  attattttt  cactaccag  gaatcctgt  2160
tcagctgtg  tcacctgca  cctctttgt  gtacccgca  tgagaaaaa  gcagggtat  2220
ttggatcct  ggccaacca  catcaaagc  aggttatca  gtgacgtaa  gctggaccc  2280
cgcccagaa  accaccggt  tatactgac  tggcatcac  aagaaccac  gccctgggc  2340
cagagtaca  gtaatcaga  gagcagccg  ctgatgagc  tgcgcagtg  caatggatt  2400
ctgatgcta  ctccaaaga  agagcagta  gtggaactt  acaaaggcg  ggtggtgga  2460
gtcatggtc  tcggacggc  atgatggtg  ccaacagga  aaagtttcg  tgcatgtcc  2520
catatcatt  actgtatcc  gtcatatgc  acggcacag  tagtttttc  gatctggat  2580
aaagttgat  tgtatagtc  acatcttga  ctatatttc  aatgaattt  aataccttt  2640
aaagaaaaa  cacacctaa  aataaatct  aacagacaa  tctattctg  ttatatcaa  2700
gcaaaattt  cctttcttg  aaattgctt  gtgtgttca  tgctaggtc  gatagcgat  2760
gctttagta  acagcggta  gtgcctgca  aacttgtgt  tttctcatc  ttaaataca  2820
ctacttatg  tcttaatca  ggctgtctg  ttctttata  tagtgtagg  aacacttgg  2880
tttcccttc  tagtatgct  cataactgc  ttacagaga  cttttgctt  ttctttctc  2940
tgtatctcg  gtttatgtg  accatgcca  aagacgagt  actgcgcgg  ggccccgct  3000
tgcctcaag  gccttccct  ctgagcacc  agggaagct  tcaccctcg  agcctctgg  3060
acacacagt  ctagcaggc  gtaactgga  accttttat  tgaacaaac  aacggggtg  3120
ggggaaatg  ttccttaag  gctgacagc  tttttaacc  acacattta  aattgtaca  3180
aacaaaaat  aaatcaaag  ctgatcttg  acagatatt  gtgttacca  cattcatgt  3240
gaatcaaga  caaaaataa  ataatgtta  acaactctg  accataaca  tttctgtaa  3300
gataatgaa  cttaatgaa  aaaaaaaaa  ccttgatca  tatttaaaa  aaaaaaaaa  3360
aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aa  3392



<210> 9907
<211> 736
<212> PRT
<213> Rattus norvegicus
<308> Q03555
<400> 9907

Met Ala Thr Glu Gly Met Ile Leu Thr Asn His Asp His Gln Ile Arg 
  1               5                  10                  15
Val Gly Val Leu Thr Val Ser Asp Ser Cys Phe Arg Asn Leu Ala Glu 
             20                  25                  30
Asp Arg Ser Gly Ile Asn Leu Lys Asp Leu Val Gln Asp Pro Ser Leu 
         35                  40                  45
Leu Gly Gly Thr Ile Ser Ala Tyr Lys Ile Val Pro Asp Glu Ile Glu 
     50                  55                  60
Glu Ile Lys Glu Thr Leu Ile Asp Trp Cys Asp Glu Lys Glu Leu Asn 
 65                  70                  75                  80
Leu Ile Leu Thr Thr Gly Gly Thr Gly Phe Ala Pro Arg Asp Val Thr 
                 85                  90                  95
Pro Glu Ala Thr Lys Glu Val Ile Glu Arg Glu Ala Pro Gly Met Ala 
             100                105                110
Leu Ala Met Leu Met Gly Ser Leu Asn Val Thr Pro Leu Gly Met Leu 
         115                120                125
Ser Arg Pro Val Cys Gly Ile Arg Gly Lys Thr Leu Ile Ile Asn Leu 
     130                135                140
Pro Gly Ser Lys Lys Gly Ser Gln Glu Cys Phe Gln Phe Ile Leu Pro 
 145                150                155                160
Ala Leu Pro His Ala Ile Asp Leu Leu Arg Asp Ala Ile Val Lys Val 
                 165                170                175
Lys Glu Val His Asp Glu Leu Glu Asp Leu Pro Ser Pro Pro Pro Pro 
             180                185                190
Leu Ser Pro Pro Pro Thr Thr Ser Pro His Lys Gln Thr Glu Asp Lys 
         195                200                205
Gly Val Gln Cys Glu Glu Glu Glu Glu Glu Lys Lys Asp Ser Gly Val 
     210                215                220
Ala Ser Thr Glu Asp Ser Ser Ser Ser His Ile Thr Ala Ala Ala Leu 
 225                230                235                240
Ala Arg Lys Ile Pro Asp Ser Ile Ile Ser Arg Gly Val Gln Val Leu 
                 245                250                255
Pro Arg Asp Thr Ala Ser Leu Ser Thr Thr Pro Ser Glu Ser Pro Arg 
             260                265                270
Ala Gln Ala Thr Ser Arg Leu Ser Thr Ala Ser Cys Pro Thr Pro Lys 
         275                280                285
Val Gln Ser Arg Cys Ser Ser Lys Glu Asn Ile Leu Arg Ala Ser His 
     290                295                300
Ser Ala Val Asp Ile Thr Lys Val Ala Arg Arg His Arg Met Ser Pro 
 305                310                315                320
Phe Pro Leu Thr Ser Met Asp Lys Ala Phe Ile Thr Val Leu Glu Met 
                 325                330                335
Thr Pro Val Leu Gly Thr Glu Ile Ile Asn Tyr Arg Asp Gly Met Gly 
             340                345                350
Arg Val Leu Ala Gln Asp Val Tyr Ala Lys Asp Asn Leu Pro Pro Phe 
         355                360                365
Pro Ala Ser Val Lys Asp Gly Tyr Ala Val Arg Ala Ala Asp Gly Pro 
     370                375                380
Gly Asp Arg Phe Ile Ile Gly Glu Ser Gln Ala Gly Glu Gln Pro Thr 
 385                390                395                400
Gln Thr Val Met Pro Gly Gln Val Met Arg Val Thr Thr Gly Ala Pro 
                 405                410                415
Ile Pro Cys Gly Ala Asp Ala Val Val Gln Val Glu Asp Thr Glu Leu 
             420                425                430
Ile Arg Glu Ser Asp Asp Gly Thr Glu Glu Leu Glu Val Arg Ile Leu 
         435                440                445
Val Gln Ala Arg Pro Gly Gln Asp Ile Arg Pro Ile Gly His Asp Ile 
     450                455                460
Lys Arg Gly Glu Cys Val Leu Ala Lys Gly Thr His Met Gly Pro Ser 
 465                470                475                480
Glu Ile Gly Leu Leu Ala Thr Val Gly Val Thr Glu Val Glu Val Asn 
                 485                490                495
Lys Phe Pro Val Val Ala Val Met Ser Thr Gly Asn Glu Leu Leu Asn 
             500                505                510
Pro Glu Asp Asp Leu Leu Pro Gly Lys Ile Arg Asp Ser Asn Arg Ser 
         515                520                525
Thr Leu Leu Ala Thr Ile Gln Glu His Gly Tyr Pro Thr Ile Asn Leu 
     530                535                540
Gly Ile Val Gly Asp Asn Pro Asp Asp Leu Leu Asn Ala Leu Asn Glu 
 545                550                555                560
Gly Ile Ser Arg Ala Asp Val Ile Ile Thr Ser Gly Gly Val Ser Met 
                 565                570                575
Gly Glu Lys Asp Tyr Leu Lys Gln Val Leu Asp Ile Asp Leu His Ala 
             580                585                590
Gln Ile His Phe Gly Arg Val Phe Met Lys Pro Gly Leu Pro Thr Thr 
         595                600                605
Phe Ala Thr Leu Asp Ile Asp Gly Val Arg Lys Ile Ile Phe Ala Leu 
     610                615                620
Pro Gly Asn Pro Val Ser Ala Val Val Thr Cys Asn Leu Phe Val Val 
 625                630                635                640
Pro Ala Leu Arg Lys Met Gln Gly Ile Leu Asp Pro Arg Pro Thr Ile 
                 645                650                655
Ile Lys Ala Arg Leu Ser Cys Asp Val Lys Leu Asp Pro Arg Pro Glu 
             660                665                670
Tyr His Arg Cys Ile Leu Thr Trp His His Gln Glu Pro Leu Pro Trp 
         675                680                685
Ala Gln Ser Thr Gly Asn Gln Met Ser Ser Arg Leu Met Ser Met Arg 
     690                695                700
Ser Ala Asn Gly Leu Leu Met Leu Pro Pro Lys Thr Glu Gln Tyr Val 
 705                710                715                720
Glu Leu His Lys Gly Glu Val Val Asp Val Met Val Ile Gly Arg Leu 
                 725                730                735



<210> 9908
<211> 1727
<212> DNA
<213> Homo sapiens
<308> AK025169
<400> 9908

gtgtgctat  ctttcctct  agtcctgcc  tctagctgc  ttgggtctc  cgctccgca  60
agcgttccg  cactctccg  cctcgttct  ccgcctccg  gcgctctcc  cgtgcggcc  120
ccgcgcccc  caagcttgc  tccttcttg  cggacttgg  gccgcgcgc  ctgactcct  180
cccctcccg  ggacccgcg  actcccggc  cggcctctc  cccacgcag  ccaccgtgc  240
ctctgtggc  tccccctcc  tccccgctc  cctcgcgct  ctctggctc  ctagctgtc  300
cgctctcct  ggcgagcgc  ctcccggcc  gcgcgctcc  ggctccggt  tctcccggc  360
cctgtcagt  cggtgactg  gctgggaaa  atggcgacc  agggaatga  ccttactaa  420
cacgaccat  aaatccgtg  cggagtcct  acagtgagt  atagttgct  caggaatct  480
gcagaagac  gcagtggga  aaatctcaa  gatctcgta  aagatcctt  tttgttggg  540
gggactata  cagcataca  gatagtacc  gatgaaata  aagaaatca  gaaattccc  600
acattccca  tttgtgggc  ccagaaagg  gccacaaaa  aagtaatag  acgggaagc  660
ccagggatg  ccctggcaa  gctgatggg  tcacttaat  ttacacctc  gggcatgct  720
tctaggcct  tatgtggaa  cagagggaa  acgctcatc  ttaacctgc  aggtagcaa  780
aaaggatct  aggaatgct  tcaattcat  ctgccagct  tacctcatg  cattgacct  840
ttacgtgat  ccattgtaa  agtaaagga  gtgcatgat  aacttgaag  tttgccttc  900
ccacctccc  ctctttccc  tcctcctac  accagcccc  ataaacaga  agaagacaa  960
ggagatcaa  gtgaggaag  ggaagaaga  aagaaagac  gtggtgttg  ttcaacaga  1020
gatagttcc  catcacata  aactgcagc  gccattgct  ccaagaagc  tccattcta  1080
accagtcct  ctgttgtca  ggcacacgg  gaacagccc  tccctggtc  catcaatta  1140
tcccatcat  caacagatg  acggattcc  gactccatc  tttctcgtg  tgttcaggt  1200
ctcccacga  acacagcct  cctcagcac  actccttca  aatcgcctc  tgctcaggc  1260
acatctcgc  tctctacag  ttcctgccc  acaccaaaa  tccagtcca  gtgcagcag  1320
aaggagaac  ttctcagag  cagtcacag  gctgtcgat  tcaccaagg  ggctagaag  1380
catcgcatg  ctccttttc  tctgacatc  atggacaaa  cctttatca  agtcctgga  1440
atgactccg  tgcttggga  agaaatcat  aattaccga  gtactatta  atttgacca  1500
tgccctttc  tttcttcat  tttttccaa  taagattca  gtaacatta  tgcacagtt  1560
tcctgaaaa  gaaagatta  taaccatta  tacagttat  atcattctt  ttttttctt  1620
tttctactc  ataagaaaa  ggctaaggg  tcagcctta  cagtataca  ggtaaaatc  1680
atgaaactg  cttttcatt  aaaaaagga  aaaaaaaaa  aaaaaaa  1727



<210> 9909
<211> 736
<212> PRT
<213> Homo sapiens
<308> Q9NQX3
<400> 9909

Met Ala Thr Glu Gly Met Ile Leu Thr Asn His Asp His Gln Ile Arg 
  1               5                  10                  15
Val Gly Val Leu Thr Val Ser Asp Ser Cys Phe Arg Asn Leu Ala Glu 
             20                  25                  30
Asp Arg Ser Gly Ile Asn Leu Lys Asp Leu Val Gln Asp Pro Ser Leu 
         35                  40                  45
Leu Gly Gly Thr Ile Ser Ala Tyr Lys Ile Val Pro Asp Glu Ile Glu 
     50                  55                  60
Glu Ile Lys Glu Thr Leu Ile Asp Trp Cys Asp Glu Lys Glu Leu Asn 
 65                  70                  75                  80
Leu Ile Leu Thr Thr Gly Gly Thr Gly Phe Ala Pro Arg Asp Val Thr 
                 85                  90                  95
Pro Glu Ala Thr Lys Glu Val Ile Glu Arg Glu Ala Pro Gly Met Ala 
             100                105                110
Leu Ala Met Leu Met Gly Ser Leu Asn Val Thr Pro Leu Gly Met Leu 
         115                120                125
Ser Arg Pro Val Cys Gly Ile Arg Gly Lys Thr Leu Ile Ile Asn Leu 
     130                135                140
Pro Gly Ser Lys Lys Gly Ser Gln Glu Cys Phe Gln Phe Ile Leu Pro 
 145                150                155                160
Ala Leu Pro His Ala Ile Asp Leu Leu Arg Asp Ala Ile Val Lys Val 
                 165                170                175
Lys Glu Val His Asp Glu Leu Glu Asp Leu Pro Ser Pro Pro Pro Pro 
             180                185                190
Leu Ser Pro Pro Pro Thr Thr Ser Pro His Lys Gln Thr Glu Asp Lys 
         195                200                205
Gly Val Gln Cys Glu Glu Glu Glu Glu Glu Lys Lys Asp Ser Gly Val 
     210                215                220
Ala Ser Thr Glu Asp Ser Ser Ser Ser His Ile Thr Ala Ala Ala Ile 
 225                230                235                240
Ala Ala Lys Ile Pro Asp Ser Ile Ile Ser Arg Gly Val Gln Val Leu 
                 245                250                255
Pro Arg Asp Thr Ala Ser Leu Ser Thr Thr Pro Ser Glu Ser Pro Arg 
             260                265                270
Ala Gln Ala Thr Ser Arg Leu Ser Thr Ala Ser Cys Pro Thr Pro Lys 
         275                280                285
Val Gln Ser Arg Cys Ser Ser Lys Glu Asn Ile Leu Arg Ala Ser His 
     290                295                300
Ser Ala Val Asp Ile Thr Lys Val Ala Arg Arg His Arg Met Ser Pro 
 305                310                315                320
Phe Pro Leu Thr Ser Met Asp Lys Ala Phe Ile Thr Val Leu Glu Met 
                 325                330                335
Thr Pro Val Leu Gly Thr Glu Ile Ile Asn Tyr Arg Asp Gly Met Gly 
             340                345                350
Arg Val Leu Ala Gln Asp Val Tyr Ala Lys Asp Asn Leu Pro Pro Phe 
         355                360                365
Pro Ala Ser Val Lys Asp Gly Tyr Ala Val Arg Ala Ala Asp Gly Pro 
     370                375                380
Gly Asp Arg Phe Ile Ile Gly Glu Ser Gln Ala Gly Glu Gln Pro Thr 
 385                390                395                400
Gln Thr Val Met Pro Gly Gln Val Met Arg Val Thr Thr Gly Ala Pro 
                 405                410                415
Ile Pro Cys Gly Ala Asp Ala Val Val Gln Val Glu Asp Thr Glu Leu 
             420                425                430
Ile Arg Glu Ser Asp Asp Gly Thr Glu Glu Leu Glu Val Arg Ile Leu 
         435                440                445
Val Gln Ala Arg Pro Gly Gln Asp Ile Arg Pro Ile Gly His Asp Ile 
     450                455                460
Lys Arg Gly Glu Cys Val Leu Ala Lys Gly Thr His Met Gly Pro Ser 
 465                470                475                480
Glu Ile Gly Leu Leu Ala Thr Val Gly Val Thr Glu Val Glu Val Asn 
                 485                490                495
Lys Phe Pro Val Val Ala Val Met Ser Thr Gly Asn Glu Leu Leu Asn 
             500                505                510
Pro Glu Asp Asp Leu Leu Pro Gly Lys Ile Arg Asp Ser Asn Arg Ser 
         515                520                525
Thr Leu Leu Ala Thr Ile Gln Glu His Gly Tyr Pro Thr Ile Asn Leu 
     530                535                540
Gly Ile Val Gly Asp Asn Pro Asp Asp Leu Leu Asn Ala Leu Asn Glu 
 545                550                555                560
Gly Ile Ser Arg Ala Asp Val Ile Ile Thr Ser Gly Gly Val Ser Met 
                 565                570                575
Gly Glu Lys Asp Tyr Leu Lys Gln Val Leu Asp Ile Asp Leu His Ala 
             580                585                590
Gln Ile His Phe Gly Arg Val Phe Met Lys Pro Gly Leu Pro Thr Thr 
         595                600                605
Phe Ala Thr Leu Asp Ile Asp Gly Val Arg Lys Ile Ile Phe Ala Leu 
     610                615                620
Pro Gly Asn Pro Val Ser Ala Val Val Thr Cys Asn Leu Phe Val Val 
 625                630                635                640
Pro Ala Leu Arg Lys Met Gln Gly Ile Leu Asp Pro Arg Pro Thr Ile 
                 645                650                655
Ile Lys Ala Arg Leu Ser Cys Asp Val Lys Leu Asp Pro Arg Pro Glu 
             660                665                670
Tyr His Arg Cys Ile Leu Thr Trp His His Gln Glu Pro Leu Pro Trp 
         675                680                685
Ala Gln Ser Thr Gly Asn Gln Met Ser Ser Arg Leu Met Ser Met Arg 
     690                695                700
Ser Ala Asn Gly Leu Leu Met Leu Pro Pro Lys Thr Glu Gln Tyr Val 
 705                710                715                720
Glu Leu His Lys Gly Glu Val Val Asp Val Met Val Ile Gly Arg Leu 
                 725                730                735



<210> 9910
<211> 3972
<212> DNA
<213> Rattus norvegicus
<308> X66494
<400> 9910

gggagttac  acacggtct  ccaagggca  tgccaagga  ggagtttct  ggacggtca  60
ggtagcatt  gcggaaaca  agccagctg  gttctgggc  gtgcagctg  agaccccca  120
gtcgtcgac  ttcacatca  tgatgaaga  cacatcgtc  tctggcata  cgtgcatgc  180
tcgctctcg  gctgcaggg  aatcggtgc  tccatcctt  tgccaggca  tctgagggt  240
agggtggcc  gtggcagca  actcgaggc  tgctgtggt  cccgtccga  tggcaatgt  300
atggggtat  ttggtgaat  aaggcaaca  attcacagt  agcctggct  tgtgtgagt  360
tgtggagcc  aagtggttt  tgatgacac  ctggtagcg  ccctcgtgt  caaacgtga  420
gtgacggag  tgcaggatg  tggtgtact  catcacttc  ccgtcccgc  cccctcccg  480
ccgcccgtc  ccccgtccc  cggcccggc  gcccccgag  cccccgggc  ggcccgcgc  540
ttcggggcc  tttctccag  tgccaccgg  gccccttgc  cgctcgcca  cctcgagac  600
ccgcgaccc  tggcctggc  tcgcggccc  ggggccatg  cgaagaaga  cgctgaaaa  660
ggtatctat  gcgtgtctg  agacgagaa  aagggtcct  tcatcgtgt  cgggcccga  720
ggtgccccg  ccaagggcg  tggccctgc  ggcctgggg  cgcccagca  ccgccttgc  780
gtgccgccg  gagagactt  gacacgcca  atggacttc  tcatgtcgt  cgtgggctt  840
gccgtgggc  tcggtaacg  gtggcgctt  ccctacctg  gctacaaga  cggcggagg  900
gtgttcctt  ttccctatg  cctgattgc  ctggttgga  gaatcccca  tttcttcct  960
gaaatctca  tgggccagt  catgaaggc  ggcagcatc  atgtctgga  catctgtcc  1020
ctattcaaa  gtctgggct  tgcctccat  gtgattgtc  tctactgca  cacttacta  1080
atcatggtg  tggcctggg  cttctatta  ctggtcaag  cctttacta  cactttgcc  1140
tgggctacg  gtggccaca  ctggaacac  cctgactgt  tagagatct  tcgccatga  1200
gactgtgcc  atgccagct  ggccaacct  acatgtgac  agcttgctg  ccgacggtc  1260
cctgtcatc  agttctggg  gaacaaagt  ttgaggctc  ccacagggc  ggaggttcc  1320
ggagccctc  actgggaag  gaccctgtg  ctgctggcc  gctgggtgc  ggtctactt  1380
tgtgtgtgg  agggggtca  gtcaacagg  aagatcgtg  acttcactg  tacattccc  1440
tacgtggtc  tcgttgtgc  gctggtgcg  ggggtgctg  tgcctggag  cctggatgg  1500
atcatctac  atctcaagc  tgactggtc  aagctaggg  cccctcagg  atggataga  1560
gctgggacc  agattttct  ctcttatgc  atcggcctg  gggccctca  agccctagg  1620
agctacaat  gcttcaaca  caactgcta  aaggatgcc  tcatcctgg  actcatcaa  1680
agcgggacc  gcttctttg  tggctttgt  gtcttctcc  tcctgggct  catggccac  1740
gagcagggt  tgcatatct  caaggtggc  gaatcaggg  ctggtctag  cttcattgc  1800
tacccacgg  ctgtcacac  gatgcctgt  gccccactc  gggctgcct  gttcttctt  1860
atgctgctg  tgctcggtc  ggacagcca  tttgtaggt  tggagggct  catcactgg  1920
ctcctggat  tcctcccgg  ctcctacta  ttccgtttt  aaagggaga  ctccgtggc  1980
ctctgttgt  ccctctgct  tgtcatcga  ctctccatg  tgactgatg  cgggatgta  2040
gtcttccag  tgtttgact  ctactcagc  agtggcact  ccctgcttt  gcaagcctt  2100
tgggagtgt  tggtggtgg  ttgggttta  ggagctgac  gcttcatgg  cgatattgc  2160
tgtatgatt  ggtaccgac  ttgcccttg  atgaaatgg  gctggtcct  cttcacccc  2220
ctggtctgc  tgggcatct  catcttcaa  gttgtgtac  acaagccac  ggtctacaa  2280
aatacctac  tgtacccat  gtggggtga  gctatgggc  gggcctttg  actctcttc  2340
atgctctgt  tgcccctcc  cctcctggg  tgtctcctc  gggcaaaag  aaccatggc  2400
gagcgatgg  agcacctga  ccagcctat  tggggcctc  atcacttgg  atacagagc  2460
caggatgca  atgtcaggg  cctgaccac  ctgactccc  tgtccgaga  cagcaaggt  2520
gtcgtggtg  agagtgtca  gtgacaggc  cccccagct  acatcacca  ctcatcctt  2580
ggtagccat  gcagcccca  ctttagccc  cacccatcc  tcgggggct  gcctttcct  2640
gacagtttg  ggatctgcc  ggggaaagg  aggaagcac  atgagtgct  acaaaaaca  2700
ctttttcca  ttttaataa  acgccaaaa  catcacaac  caccaaaaa  agatgcctc  2760
cctccccac  ccacaacta  gctggtatt  tcgttgctt  cagtcccca  ctcctttcc  2820
tcttcccag  gcccaggac  catctccta  ccttgccaa  cccatctgc  tgcctccca  2880
gctctgctc  gtaacacac  tttgcccta  aaccaacag  ggcagcttg  ggaacagga  2940
aggagggaa  ataacagta  gacaggagg  gaggcaaga  agggacagt  gaaccaagg  3000
gaatatttc  gctcaatta  aactcttcc  gcccctatt  tagaagcta  agagccagt  3060
agcaatgga  ccttgtgtt  ctgcgccaa  tgccaccaa  attaattgt  tgagcttgg  3120
tctgagtgc  cgtctgtct  tgtgtgatg  gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  3180
gtgtgtgtg  gtgtgtgtg  agatctctt  tctcttagt  aaggtgaat  ccagaagta  3240
acagagcct  tgggcaaag  aggcttata  tttgcacat  ttataagaa  aaaaaactt  3300
agagtgaga  ttctgcttg  atatttcta  aaagccccc  ccatccccc  tttccactc  3360
tttccttga  atccccacc  tctctgacc  tagccaagg  gtgtgaatt  atagactta  3420
ttttcatag  caaaacaaa  gcttcaggc  gttgaatat  tgagtctgt  tgtgtggat  3480
ttctgtatg  tctccagcc  gagactgga  taggaaggt  ggagcctca  tggtgtccc  3540
acactgttc  tttgcctct  agtctgtgg  gtagaaggc  gtaacatta  cccagggaa  3600
ctgggtctg  tcacctgac  tgctcagac  tgcccacac  cagctccct  ggctgggca  3660
gattgcagg  atttcccat  gacatagcc  agggaaggg  tcctgggta  ggcttccac  3720
tccaagcta  aggctgatg  gctttcgac  tctcaagtc  tccgtgtag  agcttaaac  3780
cacatctgt  tcccatcaa  cctgaaaca  ccaagtagc  attagaaag  ctttcttca  3840
acagagctg  actaagcca  ggaggtggg  ctgggtaag  gtgcaagcc  ttggggaca  3900
tcttactgt  ctaaaaaag  cactgcaaa  atagcaata  aaacacttc  attttccaa  3960
aaaaaaaaa  aa  3972



<210> 9911
<211> 635
<212> PRT
<213> Rattus norvegicus
<308> P28570
<400> 9911

Met Ala Lys Lys Ser Ala Glu Asn Gly Ile Tyr Ser Val Ser Gly Asp 
  1               5                  10                  15
Glu Lys Lys Gly Pro Leu Ile Val Ser Gly Pro Asp Gly Ala Pro Ser 
             20                  25                  30
Lys Gly Asp Gly Pro Ala Gly Leu Gly Ala Pro Ser Ser Arg Leu Ala 
         35                  40                  45
Val Pro Pro Arg Glu Thr Trp Thr Arg Gln Met Asp Phe Ile Met Ser 
     50                  55                  60
Cys Val Gly Phe Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr 
 65                  70                  75                  80
Leu Cys Tyr Lys Asn Gly Gly Gly Val Phe Leu Ile Pro Tyr Val Leu 
                 85                  90                  95
Ile Ala Leu Val Gly Gly Ile Pro Ile Phe Phe Leu Glu Ile Ser Leu 
             100                105                110
Gly Gln Phe Met Lys Ala Gly Ser Ile Asn Val Trp Asn Ile Cys Pro 
         115                120                125
Leu Phe Lys Gly Leu Gly Tyr Ala Ser Met Val Ile Val Phe Tyr Cys 
     130                135                140
Asn Thr Tyr Tyr Ile Met Val Leu Ala Trp Gly Phe Tyr Tyr Leu Val 
 145                150                155                160
Lys Ser Phe Thr Thr Thr Leu Pro Trp Ala Thr Cys Gly His Thr Trp 
                 165                170                175
Asn Thr Pro Asp Cys Val Glu Ile Phe Arg His Glu Asp Cys Ala Asn 
             180                185                190
Ala Ser Leu Ala Asn Leu Thr Cys Asp Gln Leu Ala Asp Arg Arg Ser 
         195                200                205
Pro Val Ile Glu Phe Trp Glu Asn Lys Val Leu Arg Leu Ser Thr Gly 
     210                215                220
Leu Glu Val Pro Gly Ala Leu Asn Trp Glu Val Thr Leu Cys Leu Leu 
 225                230                235                240
Ala Cys Trp Val Leu Val Tyr Phe Cys Val Trp Lys Gly Val Lys Ser 
                 245                250                255
Thr Gly Lys Ile Val Tyr Phe Thr Ala Thr Phe Pro Tyr Val Val Leu 
             260                265                270
Val Val Leu Leu Val Arg Gly Val Leu Leu Pro Gly Ala Leu Asp Gly 
         275                280                285
Ile Ile Tyr Tyr Leu Lys Pro Asp Trp Ser Lys Leu Gly Ser Pro Gln 
     290                295                300
Val Trp Ile Asp Ala Gly Thr Gln Ile Phe Phe Ser Tyr Ala Ile Gly 
 305                310                315                320
Leu Gly Ala Leu Thr Ala Leu Gly Ser Tyr Asn Arg Phe Asn Asn Asn 
                 325                330                335
Cys Tyr Lys Asp Ala Ile Ile Leu Ala Leu Ile Asn Ser Gly Thr Ser 
             340                345                350
Phe Phe Ala Gly Phe Val Val Phe Ser Ile Leu Gly Phe Met Ala Thr 
         355                360                365
Glu Gln Gly Val His Ile Ser Lys Val Ala Glu Ser Gly Pro Gly Leu 
     370                375                380
Ala Phe Ile Ala Tyr Pro Arg Ala Val Thr Leu Met Pro Val Ala Pro 
 385                390                395                400
Leu Trp Ala Ala Leu Phe Phe Phe Met Leu Leu Leu Leu Gly Leu Asp 
                 405                410                415
Ser Gln Phe Val Gly Val Glu Gly Phe Ile Thr Gly Leu Leu Asp Leu 
             420                425                430
Leu Pro Ala Ser Tyr Tyr Phe Arg Phe Gln Arg Glu Ile Ser Val Ala 
         435                440                445
Leu Cys Cys Ala Leu Cys Phe Val Ile Asp Leu Ser Met Val Thr Asp 
     450                455                460
Gly Gly Met Tyr Val Phe Gln Leu Phe Asp Tyr Tyr Ser Ala Ser Gly 
 465                470                475                480
Thr Thr Leu Leu Trp Gln Ala Phe Trp Glu Cys Val Val Val Ala Trp 
                 485                490                495
Val Tyr Gly Ala Asp Arg Phe Met Asp Asp Ile Ala Cys Met Ile Gly 
             500                505                510
Tyr Arg Pro Cys Pro Trp Met Lys Trp Cys Trp Ser Phe Phe Thr Pro 
         515                520                525
Leu Val Cys Met Gly Ile Phe Ile Phe Asn Val Val Tyr Tyr Lys Pro 
     530                535                540
Leu Val Tyr Asn Asn Thr Tyr Val Tyr Pro Trp Trp Gly Glu Ala Met 
 545                550                555                560
Gly Trp Ala Phe Ala Leu Ser Ser Met Leu Cys Val Pro Leu His Leu 
                 565                570                575
Leu Gly Cys Leu Leu Arg Ala Lys Gly Thr Met Ala Glu Arg Trp Gln 
             580                585                590
His Leu Thr Gln Pro Ile Trp Gly Leu His His Leu Glu Tyr Arg Ala 
         595                600                605
Gln Asp Ala Asp Val Arg Gly Leu Thr Thr Leu Thr Pro Val Ser Glu 
     610                615                620
Ser Ser Lys Val Val Val Val Glu Ser Val Met 
 625                630                635



<210> 9912
<211> 2283
<212> DNA
<213> Homo sapiens
<308> S74039
<400> 9912

ctcgcggcc  caggggcca  ggcgaagaa  agcgctgaa  acggtatct  tagcgtgtc  60
ggagacgag  agaagggtc  tctcatcgt  tccgggccc  atggtgccc  gtccaaggg  120
gatggccct  cgggcctgg  ggcgcccag  agccgcctt  ctgtgccgc  gcgagagac  180
tggacacgc  agatggact  catcatgtc  tgcgtgggc  tcgccgtgg  cctcggtaa  240
gtgtggcgc  tcccctacc  gtgctacaa  aacggcgga  gtgtgttcc  tattcccta  300
gtcctgatt  ccctggttg  aggaatccc  attttcttc  tggaaatct  actgggcca  360
ttcatgaag  ccggcagca  caatgtctg  aacatctgt  ccctattca  aggtctggg  420
tatgcctcc  tggtgattg  cttctactg  aacacttac  acatcatgg  gctggcctg  480
ggcttctat  acctggtca  gtcctttac  accactttg  catgggcta  gtgtggcca  540
acctggaac  ctcctgact  tgtagagat  tttcgacat  aagactgtg  caatgacag  600
ttggccaac  tcacatgtg  ccagcttgc  gaccggcgg  cccctgtca  cgagttctg  660
gagaacaaa  tcttgaggc  ctccacagg  ctggaggtt  caggagccc  caactggga  720
gtgaccctg  gtctgctgg  ctgctgggt  ctggtctac  tctgtgtct  gaagggggt  780
aaatccacg  gaaagatcg  gtacttcac  gctacattc  cctacgtgg  cctggtcgt  840
ctgctggtg  gtggagtgc  gctgcctgg  gccctggat  gcatcattt  ctatctcaa  900
cctgactgg  caaagctgg  gtcccctca  gtgtggata  atgcgggga  ccagatttt  960
ttctcttat  ccatcggcc  gggggccct  acagccctg  gcagctaca  tcgcttcaa  1020
aacaactgc  acaaggatg  catcatcct  gcactcatc  acagcggga  cagcttctt  1080
gctggcttt  tggtcttct  catcctggg  ttcatggcc  cagagcagg  tgtgcatat  1140
tccaaggtg  cagaatcag  gcctggtct  gccttcatt  cctacccac  ggctgtcac  1200
ctgatgcct  tggccccac  ctgggctgc  ttgttcttc  tcatgctgc  gctgctcgg  1260
ctggacagc  agtttgtag  tgtggaggg  ttcatcact  ggctcctgg  tctcctccc  1320
gcctcctac  acttccgtt  tcaaaggga  atctccgtg  ccctctgtt  tgccctctg  1380
tttgtcatc  atctctcca  ggtgactga  ggcgggatg  acgtcttcc  gctgtttga  1440
tactactca  ctagtggca  taccctgct  tggcaggcc  tttgggagt  cgtggtggt  1500
gcctgggtg  acggagctg  ccgcttcat  gacgacatt  cctgtatga  cgggtaccg  1560
ccttgcccc  ggatgaaat  gtgctggtc  ttcttcacc  cgctggtct  catgggcat  1620
ttcatcttc  acgttgtgt  ctacgagcc  ctggtctac  acaacacct  cgtgtaccc  1680
tggtggggt  aggccatgg  ctgggcctt  gccctgtcc  ccatgctgt  cgtgccgct  1740
cacctcctg  gctgcctcc  cagggccaa  ggcaccatg  ctgagcgct  gcagcacct  1800
acccagccc  tctggggcc  ccaccactt  gagtaccga  ctcaggacg  agatgtcag  1860
ggcctgacc  ccctgaccc  agtgtccga  agcagcaag  tcgtcgtgg  ggagagtgt  1920
atgtgacaa  tcagctcac  tcaccagct  acctctggt  gccatagca  cccctgctt  1980
agccccacc  cacccctcc  gggggcctg  ctttccctg  cacttttgg  gtctgcctg  2040
gggaggagg  gagaaagca  catgagtgc  cactaaaac  actttttcc  tttttaata  2100
aacgccaaa  atatcacaa  ccaccaaaa  tagatgcct  tccccctcc  gccctagcc  2160
agctggtct  gatatcaag  ttatcgata  cgtcgacct  ggagggggg  gccggtacc  2220
aattcgccc  atagtgagt  ggttttaca  attcaattg  ccgtcggtt  tacaacggt  2280
ggt  2283



<210> 9913
<211> 635
<212> PRT
<213> Homo sapiens
<308> P48029
<400> 9913

Met Ala Lys Lys Ser Ala Glu Asn Gly Ile Tyr Ser Val Ser Gly Asp 
  1               5                  10                  15
Glu Lys Lys Gly Pro Leu Ile Ala Pro Gly Pro Asp Gly Ala Pro Ala 
             20                  25                  30
Lys Gly Asp Gly Pro Val Gly Leu Gly Thr Pro Gly Gly Arg Leu Ala 
         35                  40                  45
Val Pro Pro Arg Glu Thr Trp Thr Arg Gln Met Asp Phe Ile Met Ser 
     50                  55                  60
Cys Val Gly Phe Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr 
 65                  70                  75                  80
Leu Cys Tyr Lys Asn Gly Gly Gly Val Phe Leu Ile Pro Tyr Val Leu 
                 85                  90                  95
Ile Ala Leu Val Gly Gly Ile Pro Ile Phe Phe Leu Glu Ile Ser Leu 
             100                105                110
Gly Gln Phe Met Lys Ala Gly Ser Ile Asn Val Trp Asn Ile Cys Pro 
         115                120                125
Leu Phe Lys Gly Leu Gly Tyr Ala Ser Met Val Ile Val Phe Tyr Cys 
     130                135                140
Asn Thr Tyr Tyr Ile Met Val Leu Ala Trp Gly Phe Tyr Tyr Leu Val 
 145                150                155                160
Lys Ser Phe Thr Thr Thr Leu Pro Trp Ala Thr Cys Gly His Thr Trp 
                 165                170                175
Asn Thr Pro Asp Cys Val Glu Ile Phe Arg His Glu Asp Cys Ala Asn 
             180                185                190
Ala Ser Leu Ala Asn Leu Thr Cys Asp Gln Leu Ala Asp Arg Arg Ser 
         195                200                205
Pro Val Ile Glu Phe Trp Glu Asn Lys Val Leu Arg Leu Ser Gly Gly 
     210                215                220
Leu Glu Val Pro Gly Ala Leu Asn Trp Glu Val Thr Leu Cys Leu Leu 
 225                230                235                240
Ala Cys Trp Val Leu Val Tyr Phe Cys Val Trp Lys Gly Val Lys Ser 
                 245                250                255
Thr Gly Lys Ile Val Tyr Phe Thr Ala Thr Phe Pro Tyr Val Val Leu 
             260                265                270
Val Val Leu Leu Val Arg Gly Val Leu Leu Pro Gly Ala Leu Asp Gly 
         275                280                285
Ile Ile Tyr Tyr Leu Lys Pro Asp Trp Ser Lys Leu Gly Ser Pro Gln 
     290                295                300
Val Trp Ile Asp Ala Gly Thr Gln Ile Phe Phe Ser Tyr Ala Ile Gly 
 305                310                315                320
Leu Gly Ala Leu Thr Ala Leu Gly Ser Tyr Asn Arg Phe Asn Asn Asn 
                 325                330                335
Cys Tyr Lys Asp Ala Ile Ile Leu Ala Leu Ile Asn Ser Gly Thr Ser 
             340                345                350
Phe Phe Ala Gly Phe Val Val Phe Ser Ile Leu Gly Phe Met Ala Ala 
         355                360                365
Glu Gln Gly Val His Ile Ser Lys Val Ala Glu Ser Gly Pro Gly Leu 
     370                375                380
Ala Phe Ile Ala Tyr Pro Arg Ala Val Thr Leu Met Pro Val Ala Pro 
 385                390                395                400
Leu Trp Ala Ala Leu Phe Phe Phe Met Leu Leu Leu Leu Gly Leu Asp 
                 405                410                415
Ser Gln Phe Val Gly Val Glu Gly Phe Ile Thr Gly Leu Leu Asp Leu 
             420                425                430
Leu Pro Ala Ser Tyr Tyr Phe Arg Phe Gln Arg Glu Ile Ser Val Ala 
         435                440                445
Leu Cys Cys Ala Leu Cys Phe Val Ile Asp Leu Ser Met Val Thr Asp 
     450                455                460
Gly Gly Met Tyr Val Phe Gln Leu Phe Asp Tyr Tyr Ser Ala Ser Gly 
 465                470                475                480
Thr Thr Leu Leu Trp Gln Ala Phe Trp Glu Cys Val Val Val Ala Trp 
                 485                490                495
Val Tyr Gly Ala Asp Arg Phe Met Asp Asp Ile Ala Cys Met Ile Gly 
             500                505                510
Tyr Arg Pro Cys Pro Trp Met Lys Trp Cys Trp Ser Phe Phe Thr Pro 
         515                520                525
Leu Val Cys Met Gly Ile Phe Ile Phe Asn Val Val Tyr Tyr Glu Pro 
     530                535                540
Leu Val Tyr Asn Asn Thr Tyr Val Tyr Pro Trp Trp Gly Glu Ala Met 
 545                550                555                560
Gly Trp Ala Phe Ala Leu Ser Ser Met Leu Cys Val Pro Leu His Leu 
                 565                570                575
Leu Gly Cys Leu Leu Arg Ala Lys Gly Thr Met Ala Glu Arg Trp Gln 
             580                585                590
His Leu Thr Gln Pro Ile Trp Gly Leu His His Leu Glu Tyr Arg Ala 
         595                600                605
Gln Asp Ala Asp Val Arg Gly Leu Thr Thr Leu Thr Pro Val Ser Glu 
     610                615                620
Ser Ser Lys Val Val Val Val Glu Ser Val Met 
 625                630                635



<210> 9914
<211> 2658
<212> DNA
<213> Rattus norvegicus
<308> X66845
<400> 9914

ccaagctca  gagagagga  gtgatcgct  cgggaggag  tagcctagc  gcgcagtga  60
acagcacat  ctgctggcg  gggcccgct  ctccccgtc  tcccgcgcc  cctccacca  120
ctcagtgag  ctccgcaga  agcatccag  aagcaaata  gtctgacaa  agcgaccta  180
aagctgagc  ggagcgcaa  aagcagcgc  tagcgcaga  aagagagga  aagaaacgg  240
aggaagagg  gaggaaaaa  aaagaggca  atatgcagc  gaagaaaga  cccgttcca  300
atgactccg  tctggaccg  aaacgacga  agacagaag  tttgcttca  agcatcggc  360
tatcgccgg  gccccctct  gtgcagccg  tgcattttt  aacatggga  acctgttat  420
ttcattatt  agtcccaac  cctatgtct  cctcttcga  atcagtgag  actcccagt  480
aagctggaa  ccaagacga  ctggggcca  taacaagga  cctgcagtg  gacacagac  540
cctcagtgc  ccagctgca  tcagactca  aacttggga  aagactgaa  aagctgggc  600
tgtcaaagg  tacccaggt  gatttcctg  ctagggagg  ggtatccta  tccaaggag  660
cacagactc  tcttgcaac  catcagtca  aagaggatg  ggaagatga  gagatggtt  720
agcccaaag  tggtcatga  tctgaactg  aaaatcaag  caaaaagca  gagacaaag  780
aagcccctc  aagagagct  acggaagaa  aaaaacagc  gatcctgca  tcagaggaa  840
tcctcatct  ctttgaccg  acgatccga  tgattgaac  agctctggc  gaggactct  900
acatctttt  tgactacag  ggccgagag  tggaggaga  agatgggga  gtacaggct  960
gagccaacc  ttctttcaa  cgtcagttc  atgatgagc  ttggtctaa  caccgggtg  1020
tcacatgta  ggactggtc  ctccagtac  ctgagctga  ggttgcttc  tatagcaac  1080
atgaagatg  tccccatga  ccagatgga  tggccttgg  ttggaacat  aagttcaag  1140
aaaccacac  agaatatgt  ttccactgt  agtcctctg  gatgtcagt  tgctttgcc  1200
gtttccatc  taatttggt  gttggtggc  cctattcag  ccagattgt  ctctgggac  1260
atcgcagtc  tcgaagaac  cctgtccag  ggaccccct  gtcagccgc  gcacacaca  1320
atcctgtgt  ctgtgtcaa  gttgttggg  cccagaatg  tcacaacct  atcactgtc  1380
ctaccgatg  caaaatgtg  tcctggagc  tggacatgc  ctcaacccc  caggagagc  1440
tggagctgg  gtacaacaa  tccaagcct  tggctgtta  aggaatggc  ttcccgacg  1500
gagatgtca  caacttcgt  gtcggcagt  aggaaggta  cgtctacac  gcttgtcgt  1560
atggaagca  agcaggcat  ggtgaggtc  ttgaaggtc  ccaagggcc  gtgacaggc  1620
ttaactgcc  catggcagt  ggtcccatc  acttttctc  tctgtttgt  acatcatca  1680
ttgactgga  tgtcaaact  tggaccaca  agcacaaca  gccgctcta  tcctttgaa  1740
acaatgcag  ctatgtgta  gatgtcatg  ggtcccccg  gcatcccgc  ctctttgcc  1800
gcgtggacg  gatggggcg  ttggacctc  ggaacctca  cagtgacac  gaggtgcca  1860
cagcaagtg  ggctattga  ggggcttat  ccctaaacc  ggttcgttg  gcacaaggt  1920
gtaaggaag  tgcagtagg  gactcagaa  gccgcatct  gatctacga  gttggagag  1980
ttgcggttc  ccacaatga  gaatggacg  gatttgccc  gaccctggt  gagatccgc  2040
ccaataggg  tgacagcga  gaggaaggt  cggttgagt  agctgccta  atgtgagcc  2100
agtctgcac  ctgtggctc  catccttcc  ttctagaac  cagtctgca  ccaaggccc  2160
tgtgcagtg  ttggtgtcc  ttccgtatc  gtgtccccg  ggcaacttg  gtgccatat  2220
gtgcagtgt  tccccatat  ctccccatg  accctactc  cccgaaatc  accacagca  2280
ttctacctt  gtgtccctg  ctcaagaaa  aaaatgggg  agggaaccc  taggggttt  2340
gttgttgcc  tttaactac  tggtagctg  atttaatag  tggaaacct  tggttgaat  2400
tgtgcttac  tgtacttct  gcgtagtcc  attaaatcc  tatgaagcc  gatatgatt  2460
ggtgcagat  tggcgtgcc  cgtgatacg  tgcagggcc  aagacttga  atgtggtgt  2520
ttacatggt  attcacatt  tgaatggat  tactacaag  acattgctg  tccttattt  2580
ttgtaacgt  ctgcatgga  catatttat  tgaaagcat  aaaataaac  atcttagag  2640
aaaaaaaaa  aaaaaaaa  2658



<210> 9915
<211> 643
<212> PRT
<213> Rattus norvegicus
<308> Q63100
<400> 9915

Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
  1               5                  10                  15
Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
             20                  25                  30
Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Pro Asp 
         35                  40                  45
Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
     50                  55                  60
Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Gln Pro Leu His Phe 
 65                  70                  75                  80
Leu Thr Trp Asp Thr Cys Tyr Phe His Tyr Leu Val Pro Thr Pro Met 
                 85                  90                  95
Ser Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln 
             100                105                110
Asp Asp Leu Gly Pro Leu Thr Arg Thr Leu Gln Trp Asp Thr Asp Pro 
         115                120                125
Ser Val Leu Gln Leu Gln Ser Asp Ser Glu Leu Gly Arg Arg Leu Asn 
     130                135                140
Lys Leu Gly Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro Arg Glu 
 145                150                155                160
Val Val Ser Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr His Gln 
                 165                170                175
Ser Glu Glu Asp Glu Glu Asp Glu Glu Met Val Glu Pro Lys Val Gly 
             180                185                190
His Asp Ser Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Thr Lys Glu 
         195                200                205
Ala Pro Pro Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile Leu His 
     210                215                220
Ser Glu Glu Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val Ile Glu 
 225                230                235                240
Arg Ala Leu Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser Gly Arg 
                 245                250                255
Glu Leu Glu Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn Leu Ser 
             260                265                270
Phe Asn Arg Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg Val Val 
         275                280                285
Thr Cys Met Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val Ala Ser 
     290                295                300
Tyr Ser Asn Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val Ala Leu 
 305                310                315                320
Val Trp Asn Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val Phe His 
                 325                330                335
Cys Gln Ser Ser Val Met Ser Val Cys Phe Ala Arg Phe His Pro Asn 
             340                345                350
Leu Val Val Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp Asp Asn 
         355                360                365
Arg Ser His Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser Ala Ala 
     370                375                380
Ala His Thr His Pro Val Tyr Cys Val Asn Val Val Gly Thr Gln Asn 
 385                390                395                400
Ala His Asn Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys Ser Trp 
                 405                410                415
Ser Leu Asp Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu Val Tyr 
             420                425                430
Asn Lys Ser Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro Thr Gly 
         435                440                445
Asp Val Asn Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val Tyr Thr 
     450                455                460
Ala Cys Arg His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe Glu Gly 
 465                470                475                480
His Gln Gly Pro Val Thr Gly Ile Asn Cys His Met Ala Val Gly Pro 
                 485                490                495
Ile Asp Phe Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp Thr Val 
             500                505                510
Lys Leu Trp Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe Glu Asp 
         515                520                525
Asn Ala Asp Tyr Val Tyr Asp Val Met Trp Ser Pro Val His Pro Ala 
     530                535                540
Leu Phe Ala Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp Asn Leu 
 545                550                555                560
Asn Ser Asp Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu Gly Ala 
                 565                570                575
Tyr Ala Leu Asn Arg Val Arg Trp Ala Gln Gly Gly Lys Glu Val Ala 
             580                585                590
Val Gly Asp Ser Glu Gly Arg Ile Trp Ile Tyr Asp Val Gly Glu Leu 
         595                600                605
Ala Val Pro His Asn Asp Glu Trp Thr Arg Phe Ala Arg Thr Leu Val 
     610                615                620
Glu Ile Arg Ala Asn Arg Ala Asp Ser Glu Glu Glu Gly Ala Val Glu 
 625                630                635                640
Leu Ala Ala 
                 645



<210> 9916
<211> 2950
<212> DNA
<213> Homo sapiens
<308> AF063228
<400> 9916

cctgggaga  aggaagtga  cgctcccgg  gagccgagc  gagcgccgg  gcacggtga  60
acagcacat  ctgcccgcg  cggccccgc  ccttcggga  ccgcctgca  caacgctgc  120
gccgccagg  gccgccgcc  ctcggggag  cagttccgc  gctgccgag  gcgtccagg  180
aaccaacat  tctgacaaa  gtgacttaa  agctgagct  gagcgcaaa  agcagcgct  240
agcacagat  agagaagag  agaaacgga  ggaagagga  aggaaaaag  aagaggctg  300
tatgcagca  aagaaagaa  ccgttcagg  cgactctga  ctggatcgc  aacgacgag  360
gacagaggc  ttgctgcaa  gcattggta  ctcaccgga  ccgcctcta  tgcagccgc  420
gcatttttt  acatgggat  cctgttatt  tcattattt  gtcccaacc  ctatgtctc  480
ctcctcgaa  tcagtgagc  ctcccagtg  agctggaag  caagactca  gcgatctgg  540
gccattaac  aggaccctg  agtgggaca  agacccctc  gtgctccag  tgcagtcag  600
ctcagaact  ggaagaaga  tgcataaac  gggcgtgtc  aaggtcacc  aagtggatt  660
cctgccaag  gaagtagtg  cctactcaa  ggagaccca  actcctctt  ccacgcatc  720
gtctgaaga  gatgaggaa  atgaggaaa  ggtggaatc  aaagttggc  aggactcag  780
actggaaaa  caggacaaa  aacaggaag  gaaggaagc  cctccaaga  agttgacag  840
ggaagaaaa  cagcagatc  ttcattcag  ggaatttct  atctttttt  accggacaa  900
acgggtaat  gaaagagcc  tggctgaag  ttccgacat  ttttttgac  acagcggcc  960
agagttaga  gaaaaagat  gggatgttc  ggctggagc  aatctttct  tcaatcgtc  1020
gttctatga  gaacattgg  ccaagcatc  agtggtcac  tgtatggac  ggtccctcc  1080
gtaccctga  ctgatggtg  cttcttaca  caacaatga  gatgctccc  atgaaccag  1140
tggagtggc  ttggtttgg  acatgaagt  taagaaaac  acaccagaa  acgtcttcc  1200
ctgtcagtc  tctgtgatg  cggtctgct  cgcccgttt  catcctaac  tggtggttg  1260
tgggactta  tcgggccag  ttgtcctct  ggacaatcg  agtcatcga  ggactccag  1320
gcagcggac  cccttatca  ctgctgcac  cacgcatcc  gtgtactgt  taaatgttg  1380
tgggaccca  aatgctcat  acctcatca  tgtctccac  gatggcaaa  tgtgttcct  1440
gagcctgga  atgctctca  ctccacagg  gagcatgga  ctggtgtac  ataagtcca  1500
gcctgtcgc  gttaccgga  tggctttcc  aacgggaga  gtcaataac  tcgtggttg  1560
cagtgagga  ggtacagtc  acacggctt  tcgtcatgg  agcaaagca  gtattggtg  1620
ggtctttga  ggtcaccaa  ggccagtga  aggaattaa  tgccacatg  cagtgggac  1680
aatcgactt  tctcacctg  ttgtcacat  atcatttga  tggactgtc  aactgtgga  1740
caccaagca  aacaagccg  tctactcct  tgaagacaa  gcagactat  tgtacgatg  1800
catgtggtc  cccgtgcat  ctgcgcttt  tgcctgcgt  gacgggatg  ggcgcttgg  1860
cctctggaa  ctcaacaat  acaccgagg  gccaacagc  agtgtggcc  ttgaggggg  1920
atccgccct  aaccgtgtt  gttgggccc  agctggcaa  gaagttgct  ttggggact  1980
ggaaggccg  atttgggtc  atgacgttg  agagcttgc  gttccccac  atgatgaat  2040
gacccgatt  gccaggacc  ttgtggaaa  tcgtgctaa  agagctgat  gcgaggagg  2100
aggcactgt  gagttatct  cctagtgga  atgagccac  cccactgca  cccccacct  2160
tgtgtccta  agctcagcg  ctgcagtca  gtctcttgt  ttcggtgtc  attcagtat  2220
agtattgct  tgacatttt  ggtgccata  tgtgccagc  ttgctccaa  tattctaaa  2280
gtgtcccat  atgctttcc  ctgacccaa  attcaccac  gcatttcta  ctttattat  2340
tctgtctca  aaatgaaga  aagggggtt  tgggttaag  tgctgcctt  taactactt  2400
gtagctgta  ttaatagct  gaaacctct  gttgaattt  tgcttacat  cactcctgg  2460
atagtccta  taaatccat  tgaagccag  tatgattgg  tgcagatgt  gtgttcctc  2520
tattatggt  cagggccaa  gacttgaga  gtggtgttt  acatggtga  tcacattat  2580
aatggattt  ctagaagaa  attgctgct  cttatttat  gtagtgtgc  gcatggaac  2640
tatttattt  aaagcatta  aataaatga  cctagagca  gtgcataat  agaggactg  2700
attctctct  ctgctgttg  ggttatatt  agttccaca  agcaattac  gtatgccag  2760
tccactgaa  acatgaaat  tttagaggt  tcttgcagt  aacgaaatg  attttaagt  2820
cttattatc  ggtacttta  caatatttc  aatatcatt  accactaat  cttctcact  2880
aagctaaca  agtctgaga  aagtctatg  ttcctaaat  tgacatcag  gttgccaat  2940
aaaccaaaaa  2950



<210> 9917
<211> 645
<212> PRT
<213> Homo sapiens
<308> O14576
<400> 9917

Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
  1               5                  10                  15
Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
             20                  25                  30
Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp 
         35                  40                  45
Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
     50                  55                  60
Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Gln Pro Leu His Phe 
 65                  70                  75                  80
Leu Thr Trp Asp Thr Cys Tyr Phe His Tyr Leu Val Pro Thr Pro Met 
                 85                  90                  95
Ser Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln 
             100                105                110
Asp Ser Gly Asp Leu Gly Pro Leu Thr Arg Thr Leu Gln Trp Asp Thr 
         115                120                125
Asp Pro Ser Val Leu Gln Leu Gln Ser Asp Ser Glu Leu Gly Arg Arg 
     130                135                140
Leu His Lys Leu Gly Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro 
 145                150                155                160
Arg Glu Val Val Ser Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr 
                 165                170                175
His Gln Ser Glu Glu Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys 
             180                185                190
Val Gly Gln Asp Ser Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val 
         195                200                205
Lys Glu Ala Pro Pro Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile 
     210                215                220
Leu His Ser Glu Glu Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val 
 225                230                235                240
Ile Glu Arg Ala Leu Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser 
                 245                250                255
Gly Arg Glu Leu Glu Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn 
             260                265                270
Leu Ser Phe Asn Arg Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg 
         275                280                285
Val Val Thr Cys Met Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val 
     290                295                300
Ala Ser Tyr Asn Asn Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val 
 305                310                315                320
Ala Leu Val Trp Asn Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val 
                 325                330                335
Phe His Cys Gln Ser Ser Val Met Ser Val Cys Phe Ala Arg Phe His 
             340                345                350
Pro Asn Leu Val Val Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp 
         355                360                365
Asp Asn Arg Ser His Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser 
     370                375                380
Ala Ala Ala His Thr His Pro Val Tyr Cys Val Asn Val Val Gly Thr 
 385                390                395                400
Gln Asn Ala His Asn Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys 
                 405                410                415
Ser Trp Ser Leu Asp Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu 
             420                425                430
Val Tyr Asn Lys Ser Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro 
         435                440                445
Thr Gly Asp Val Asn Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val 
     450                455                460
Tyr Thr Ala Cys Arg His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe 
 465                470                475                480
Glu Gly His Gln Gly Pro Val Thr Gly Ile Asn Cys His Met Ala Val 
                 485                490                495
Gly Pro Ile Asp Phe Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp 
             500                505                510
Thr Val Lys Leu Trp Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe 
         515                520                525
Glu Asp Asn Ala Asp Tyr Val Tyr Asp Val Met Trp Ser Pro Val His 
     530                535                540
Pro Ala Leu Phe Ala Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp 
 545                550                555                560
Asn Leu Asn Asn Asp Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu 
                 565                570                575
Gly Ala Ser Ala Leu Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu 
             580                585                590
Val Ala Val Gly Asp Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly 
         595                600                605
Glu Leu Ala Val Pro His Asn Asp Glu Trp Thr Arg Phe Ala Arg Thr 
     610                615                620
Leu Val Glu Ile Arg Ala Asn Arg Ala Asp Ser Glu Glu Glu Gly Thr 
 625                630                635                640
Val Glu Leu Ser Ala 
                 645



<210> 9918
<211> 3091
<212> DNA
<213> Rattus norvegicus
<308> X66870
<400> 9918

gccaaccca  atcccgagg  gcgccacgc  cagcccaga  ctccacgcc  gccaggagc  60
agcttcgcc  gctcgctgt  ccccgagca  cctctgtcc  tctgtccga  tcccgcgcc  120
ttctcggga  ccctgccca  cggcagcac  gccaccctg  cggccatgg  gaccccgtc  180
cagcggcgg  ccacccgca  tggggcgca  gccagctct  cccctggtc  cccactcgg  240
tcacacggc  gcaggagaa  gaggacctg  aggagctca  tgaccgtct  gccgtgtac  300
tcgatcgcg  gcgctccct  gagacggag  acgcggggc  gcgccttcg  atcactgag  360
ctgaagagg  ggtcagccg  gaggtgtcc  gcatcaagg  ggcctacga  cgagctggg  420
gatgcccgc  agaccctcg  ctctgtggc  aaggagcgc  cccgcctcc  gttggagct  480
agcaaagtg  gtgaggagt  caaggagct  aaggcgcgc  ataccaaga  ggaggggga  540
ttgttggct  cgcaggccc  gctcaagga  ctggaggct  ttctcaact  caaggaggc  600
gccctgagc  ctgctctca  tgagaaacg  acgttggaa  gcgagctcc  tgatctgcg  660
gggcaggta  ccaagcttg  ggcagccct  ggtgaggct  agaagcaac  ccaggatga  720
atgctgagg  gagtggatg  tgagaacag  ctacagacc  tgaaggagg  gctggattt  780
cagaagaac  tttacagtg  ggaactgcg  gagaccaag  gccggcacg  gacccggct  840
gtggagatt  ataatggga  gcagcgaga  tttgagagc  ggctggcag  tgctctgca  900
gagctgcgg  cccagcatg  ggaccaggt  gagcagtac  agaaggagc  agaaaagac  960
tactctgcc  agctggata  tgcccggca  tctgccgag  ggaacagca  cctcgtggg  1020
gctgcccat  aggagctcc  gcagtctcg  atccgcatt  acagcctct  agcccagct  1080
agccagctc  agaagcagt  ggcagccaa  gaggccaag  tgcgtgacc  ggaggactc  1140
ctggcccgt  agcgggata  cagccggcg  ctgctggct  aaaaagagc  ggagatggc  1200
gagatgcgg  caaggatgc  gcagcagct  gatgagtac  aggaattgc  ggacatcaa  1260
ctggccctg  acatggaga  ccatgccta  cgaaagctg  tggagggcg  ggaggagag  1320
ctacgcctg  cccccagcc  tacctcgca  cgcagccgt  gccgcgcct  ctcccactc  1380
tcccagtct  agggtggag  cagcgtcac  aaaaagcgc  agctggagt  ttctgagag  1440
cggagcagc  tctcgcagc  tgctcgcac  agcggccgt  tggccgtag  ggaagtaga  1500
gaagagggc  agttcgtgc  gctgcgcaa  aagtccaac  aggaccagt  catgggcaa  1560
tggcagatc  ggcgtcaga  tggtgatga  cctttgatg  cttatcgct  cccaccgaa  1620
ttcacccta  aggccgggc  ggtggtgac  atctgggct  caggagctg  ggccaccca  1680
agcccccct  ctgacttgg  gtggaaggc  cagaacact  ggggctgtg  gagcagcct  1740
cgcacggct  tcatcaacg  cactggaga  gaagtggcc  tgcgcaagc  ggtgcgctc  1800
ctgaccatg  ttgaggaca  tgacgatga  gaagaggat  gagatgagc  gctccatca  1860
caccgtggc  cccactgca  cagctcggg  gaccccgct  agtacaacc  gccgtcagc  1920
ccgtgctgt  cgggacatg  gggcagcct  ctgacaagg  tgccagtgg  tcaggaccg  1980
aggtgggcg  atccatctc  tctggctct  ctgcctcca  tgtcacagt  actcgaagc  2040
tccgcagtg  ggggggcag  gggggtggc  gcttcgggg  caacctagt  acccgctcc  2100
acctcctgg  caactccag  ccccggacc  agagctccc  gaactgcag  atcatgtaa  2160
ctgggacct  ccaggcgag  gtgggggca  aggccacct  ctccctctt  accacatgc  2220
acctcctgc  ctgttcctt  tgagagcag  tctgaagcc  aagaaaact  tcccctgcc  2280
ttgggtgtt  ttctttttt  cttctattt  ttttctaag  gaagttatt  tctacagtg  2340
ttttatact  aaggaaaaa  acaagcaaa  aaaaaaaag  gtctttatc  caatcctta  2400
tccttccct  ttccctgta  ctgccttaa  ccaaagggc  tctcatagg  gcccaggga  2460
aggactgct  ttgtagtct  gatttttgt  ctgctgcct  gcgtttgcc  tcatcccag  2520
accctgtga  acggtgcct  agaggcagg  atggagttc  ctttaccgg  ctcctccac  2580
gctggccca  tgccatgcc  gctgcaaag  aaaggggtg  agagagaat  actgaaagg  2640
caagcccct  ctggctcac  acacttggc  gagactcct  tgcctgcct  accctcctg  2700
cttcccgag  ctgggacga  tggattccc  gaggcaaat  tgccatgct  gcttttttc  2760
atattgtat  cagacaaga  atgggaaag  tggggaagg  gaagggacg  tcagtttga  2820
cctaccttt  ccccgtgcg  acagcctgc  ggtgggctc  gtctgtcgg  ggagggcag  2880
attaagtgg  attggggag  gagtgaggg  aaggctcct  gagattggg  gaacctgct  2940
gggccagtg  gaagactag  gggtgtggt  attggtggc  acagcaaac  ctaaggaac  3000
cttcattcc  acttcccat  tgcacctct  ctctccccc  aaatcaata  actagttgt  3060
tccatcccg  aaaaaaaaa  aaaaaaaaa  a  3091



<210> 9919
<211> 665
<212> PRT
<213> Rattus norvegicus
<308> P48679
<400> 9919

Met Glu Thr Pro Ser Gln Arg Arg Pro Thr Arg Ser Gly Ala Gln Ala 
  1               5                  10                  15
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys 
             20                  25                  30
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg 
         35                  40                  45
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr 
     50                  55                  60
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala 
 65                  70                  75                  80
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala 
                 85                  90                  95
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu 
             100                105                110
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Leu 
         115                120                125
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 
     130                135                140
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 
 145                150                155                160
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 
                 165                170                175
Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 
             180                185                190
Ala Glu Asn Arg Leu Gln Thr Leu Lys Glu Glu Leu Asp Phe Gln Lys 
         195                200                205
Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 
     210                215                220
Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 
 225                230                235                240
Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 
                 245                250                255
Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 
             260                265                270
Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 
         275                280                285
His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 
     290                295                300
Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 
 305                310                315                320
Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 
                 325                330                335
Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 
             340                345                350
Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 
         355                360                365
Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 
     370                375                380
Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 
 385                390                395                400
Arg Ala Ser Ser His Ser Ser Gln Ser Gln Gly Gly Gly Ser Val Thr 
                 405                410                415
Lys Lys Arg Lys Leu Glu Ser Ser Glu Ser Arg Ser Ser Phe Ser Gln 
             420                425                430
His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 
         435                440                445
Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 
     450                455                460
Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Met Thr 
 465                470                475                480
Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 
                 485                490                495
Ile Trp Ala Ser Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 
             500                505                510
Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Thr Ser Leu Arg Thr 
         515                520                525
Ala Leu Ile Asn Ala Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val 
     530                535                540
Arg Ser Leu Thr Met Val Glu Asp Asn Asp Asp Glu Glu Glu Asp Gly 
 545                550                555                560
Asp Glu Leu Leu His His His Arg Gly Ser His Cys Ser Ser Ser Gly 
                 565                570                575
Asp Pro Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr 
             580                585                590
Cys Gly Gln Pro Ala Asp Lys Ala Ala Ser Gly Ser Gly Ala Gln Val 
         595                600                605
Gly Gly Ser Ile Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val Thr 
     610                615                620
Arg Ser Phe Arg Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly Asp 
 625                630                635                640
Asn Leu Val Thr Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg Thr 
                 645                650                655
Gln Ser Ser Gln Asn Cys Ser Ile Met 
             660                665



<210> 9920
<211> 848
<212> DNA
<213> Homo sapiens
<308> AF381029
<400> 9920

gcctaccgc  agctcttgg  gggcgagga  gagaggcta  gcctgtccc  cagccctac  60
tcgcagcgc  gccgtggcc  tgcttcctc  cactcatcc  agacacagg  tgggggcag  120
gtcaccaaa  agcgcaaac  ggagtccac  gagagccgc  gcagcttct  acagcacgc  180
cgcactagc  ggcgcgtgg  cgtggagga  gtggatgag  agggcaagt  tgtccggct  240
cgcaacaag  ccaatgagg  ccagtccat  ggcaattgg  agatcaagc  ccagaatgg  300
gatgatccc  tgctgactt  ccggttccc  ccaaagttc  ccctgaagg  tgggcaggt  360
gtgacgatc  gggctgcag  agctggggc  acccacagc  cccctaccg  cctggtgtg  420
aaggcacag  acacctggg  ctgcgggaa  agcctgcgt  cggctctca  caactccac  480
ggggaaggc  cccactgca  cagctcggg  gaccccgct  agtacaacc  gcgctcgcg  540
accgtgctg  gcgggacct  cgggcagcc  gccgacaag  catctgcca  cggctcagg  600
gcccaggtg  gcggaccca  ctcctctgg  tcttctgcc  ccagtgtca  ggtcactcg  660
agctaccgc  gtgtggggg  cagtggggg  ggcagcttc  gggacaatc  ggtcacccg  720
tcctacctc  tgggcaact  cagcccccg  acccagagc  cccagaact  cagcatcat  780
taatctggg  cctgccagg  aggggtggg  gtggaggct  cctgcgtcc  cctcacctc  840
tgcccacc  848



<210> 9921
<211> 664
<212> PRT
<213> Homo sapiens
<308> P02545
<400> 9921

Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala 
  1               5                  10                  15
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys 
             20                  25                  30
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg 
         35                  40                  45
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr 
     50                  55                  60
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala 
 65                  70                  75                  80
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala 
                 85                  90                  95
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu 
             100                105                110
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile 
         115                120                125
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 
     130                135                140
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 
 145                150                155                160
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 
                 165                170                175
Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 
             180                185                190
Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys 
         195                200                205
Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 
     210                215                220
Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 
 225                230                235                240
Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 
                 245                250                255
Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 
             260                265                270
Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 
         275                280                285
His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 
     290                295                300
Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 
 305                310                315                320
Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 
                 325                330                335
Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 
             340                345                350
Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 
         355                360                365
Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 
     370                375                380
Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 
 385                390                395                400
Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr 
                 405                410                415
Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln 
             420                425                430
His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 
         435                440                445
Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 
     450                455                460
Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr 
 465                470                475                480
Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 
                 485                490                495
Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 
             500                505                510
Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr 
         515                520                525
Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val 
     530                535                540
Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp 
 545                550                555                560
Leu Leu His His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro 
                 565                570                575
Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr Cys Gly 
             580                585                590
Gln Pro Ala Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln Val Gly 
         595                600                605
Gly Pro Ile Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val Thr Arg 
     610                615                620
Ser Tyr Arg Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly Asp Asn 
 625                630                635                640
Leu Val Thr Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg Thr Gln 
                 645                650                655
Ser Pro Gln Asn Cys Ser Ile Met 
             660



<210> 9922
<211> 1449
<212> DNA
<213> Rattus norvegicus
<308> X66974
<400> 9922

gggcggcac  gagtgacag  gctgagagg  ttaagatct  cggagccgc  cgccatggc  60
ggcccgcag  agcagcccc  ttacctgca  ctggccgag  tgactgcat  ccagttcct  120
gaaatctgg  agcactttg  tgctgacgg  aatgggtac  ttgaaggta  agagctaga  180
aacttcttc  aggagctgg  gaaggcaag  aaaggttct  gcatgatgt  caagagcga  240
aattttgga  agaagatga  ggagttcat  cagaagtat  ataagaact  agatgggaa  300
attgagatg  cagagctgg  gcagatcct  ccaaccgaa  agaatttcc  tttgtgctt  360
aggcagcac  tgggctcca  cgctgagtt  atggaggct  ggcggaagt  tgacacaga  420
agaagtggc  acatcgaag  aaatgagct  aagggattt  tgtccgacc  cctgaagaa  480
gccaaccgt  cctatgatg  acctaagct  caggagtac  cccaaacca  actacgcat  540
tttgactta  atggagacg  caaattggg  ctctcagag  tgtctagac  cttgcctgt  600
caagaaaac  tcctgctga  atttcaggg  atgaagctg  cctcagaag  gttcaatgc  660
atcttcaca  tctatgaca  ggatggaag  ggctacatc  atgagaacg  gctggacgc  720
ctcctgaag  atctgtatg  gaagaacaa  aaggagatg  atatccagc  gctcaccac  780
tacaggaag  gcgtcatgt  cttggccga  gcagggaaa  tctacagaa  ggacctgga  840
attgtgctt  gcagtgagc  ccccatgta  aggggtgaa  ggacagggg  tgcttctgc  900
cctccccta  accctgccc  ccactgccc  gactctctt  aaactcctt  ccagacctc  960
ccacccctg  aacctgcac  caccagcct  tggggcagg  aaggagaga  ggaaagagg  1020
tggctggta  cattccttt  agctgcacc  gcccaaccc  ggcctgaca  acagctgtg  1080
ctgtggtgg  tgggtcaca  ggttggtgg  taggggcac  ggtggggct  ccctagtct  1140
tttgctgtg  tgcatgagc  cctcgctgt  tgattagct  ccgagtcca  cagagtgca  1200
tccttcctc  tgctgcacc  gcctccttc  ccccaggcc  cccactgac  cccgcaatt  1260
caggttctg  ccaccggct  gctaatgat  taactgtct  ctcagagct  ctgtggagg  1320
tcattgccc  cttcttgtg  tcttgactt  tgtgttcct  ttattttgg  gtttccctg  1380
cttctcgtt  accaaagaa  agtttacag  gaataaagt  gaaatgtcc  gccgtgaaa  1440
aaaaaaaaa  1449



<210> 9923
<211> 271
<212> PRT
<213> Rattus norvegicus
<308> P47728
<400> 9923

Met Ala Gly Pro Gln Gln Gln Pro Pro Tyr Leu His Leu Ala Glu Leu 
  1               5                  10                  15
Thr Ala Ser Gln Phe Leu Glu Ile Trp Lys His Phe Asp Ala Asp Gly 
             20                  25                  30
Asn Gly Tyr Ile Glu Gly Lys Glu Leu Glu Asn Phe Phe Gln Glu Leu 
         35                  40                  45
Glu Lys Ala Arg Lys Gly Ser Gly Met Met Ser Lys Ser Asp Asn Phe 
     50                  55                  60
Gly Glu Lys Met Lys Glu Phe Met Gln Lys Tyr Asp Lys Asn Ser Asp 
 65                  70                  75                  80
Gly Lys Ile Glu Met Ala Glu Leu Ala Gln Ile Leu Pro Thr Glu Glu 
                 85                  90                  95
Asn Phe Leu Leu Cys Phe Arg Gln His Val Gly Ser Ser Ala Glu Phe 
             100                105                110
Met Glu Ala Trp Arg Lys Tyr Asp Thr Asp Arg Ser Gly Tyr Ile Glu 
         115                120                125
Ala Asn Glu Leu Lys Gly Phe Leu Ser Asp Leu Leu Lys Lys Ala Asn 
     130                135                140
Arg Pro Tyr Asp Glu Pro Lys Leu Gln Glu Tyr Thr Gln Thr Ile Leu 
 145                150                155                160
Arg Met Phe Asp Leu Asn Gly Asp Gly Lys Leu Gly Leu Ser Glu Met 
                 165                170                175
Ser Arg Leu Leu Pro Val Gln Glu Asn Phe Leu Leu Lys Phe Gln Gly 
             180                185                190
Met Lys Leu Thr Ser Glu Glu Phe Asn Ala Ile Phe Thr Phe Tyr Asp 
         195                200                205
Lys Asp Gly Ser Gly Tyr Ile Asp Glu Asn Glu Leu Asp Ala Leu Leu 
     210                215                220
Lys Asp Leu Tyr Glu Lys Asn Lys Lys Glu Met Asn Ile Gln Gln Leu 
 225                230                235                240
Thr Thr Tyr Arg Lys Ser Val Met Ser Leu Ala Glu Ala Gly Lys Leu 
                 245                250                255
Tyr Arg Lys Asp Leu Glu Ile Val Leu Cys Ser Glu Pro Pro Met 
             260                265                270



<210> 9924
<211> 1413
<212> DNA
<213> Homo sapiens
<308> NM_007087
<400> 9924

agcgcgagt  ccagagccc  gccggcgcg  agcgggagc  gtgcaggct  aggtctccg  60
gcggctcgc  atggctggc  cgcagcagc  gccccctta  ctgcacctg  ccgagctga  120
ggcgtccca  ttcctggaa  tatggaagc  ctttgacgc  gacggaaat  ggtatattg  180
aggtaaaga  ctagaaaac  ttttccaag  gctggagaa  gcaaggaaa  gctctggca  240
gatgtcaaa  agtgacaac  ttggagaaa  gatgaagga  ttcatgcag  agtatgata  300
aaactcaga  gggaaaatc  agatggcag  gctggcgca  atcctgcca  ccgaagaga  360
cttccttct  tgcttcagg  agcacgtgg  ctccagcgc  gagtttatg  aggcttggc  420
gaagtacga  acagacagg  gtggctaca  cgaagccaa  gagctcaag  gattcctgt  480
agacctgct  aagaaggcg  accggccgt  cgatgagcc  aagctccag  aatacaccc  540
aaccatact  cggatgttt  acttgaacg  ggatggcaa  ttgggcctc  cagagatgt  600
ccgggcatg  agctgacct  agaggagtt  aacgcgatc  tcacatttt  cgacaagga  660
agaagcggc  acattgacg  gcatgagct  gatgccctt  tgaaggatc  gtacgagaa  720
aacaaaaag  aaatcaata  tcaacagct  accaactac  gaaagagcg  catgtcctt  780
gcagaggca  ggaagctct  ccgcaagga  ctggagatt  tgctctgca  cgagccccc  840
atgtaaagt  gggacgggg  ctgcttctc  acctccccc  aaccctgct  ctgctgccc  900
gatgcgtct  cccagactc  gagaccgtg  gcgccccgc  cccacccct  cagcctgca  960
acacctgcc  gcagagcag  aaacgagag  tagaggatg  gcagctggg  ggctgtcct  1020
agccccctg  acccacccc  gcccaggca  tctttgctc  gtggatcac  cacatggaa  1080
gtgatgggg  catgggtgg  gggtcccta  ttctcttcg  tgtgatgca  gagctccct  1140
gctgtatga  ttaggcttc  atgtccaac  gagtggact  ttccctctc  ctcccctct  1200
ccggtcccc  atgccacca  ccaccccaa  cttccaggt  ccatccacc  ccttgccaa  1260
ggtgtagct  tcctctcag  actcctgtg  gtggaaggc  cccgccctt  ccttgcctt  1320
tttactcgg  gtgctcctt  tctctttgg  tttcttgtt  accaaagaa  agtttacag  1380
caataaaat  gaaaggtcc  gctgtggaa  ctt  1413



<210> 9925
<211> 271
<212> PRT
<213> Homo sapiens
<308> P22676
<400> 9925

Met Ala Gly Pro Gln Gln Gln Pro Pro Tyr Leu His Leu Ala Glu Leu 
  1               5                  10                  15
Thr Ala Ser Gln Phe Leu Glu Ile Trp Lys His Phe Asp Ala Asp Gly 
             20                  25                  30
Asn Gly Tyr Ile Glu Gly Lys Glu Leu Glu Asn Phe Phe Gln Glu Leu 
         35                  40                  45
Glu Lys Ala Arg Lys Gly Ser Gly Met Met Ser Lys Ser Asp Asn Phe 
     50                  55                  60
Gly Glu Lys Met Lys Glu Phe Met Gln Lys Tyr Asp Lys Asn Ser Asp 
 65                  70                  75                  80
Gly Lys Ile Glu Met Ala Glu Leu Ala Gln Ile Leu Pro Thr Glu Glu 
                 85                  90                  95
Asn Phe Leu Leu Cys Phe Arg Gln His Val Gly Ser Ser Ala Glu Phe 
             100                105                110
Met Glu Ala Trp Arg Lys Tyr Asp Thr Asp Arg Ser Gly Tyr Ile Glu 
         115                120                125
Ala Asn Glu Leu Lys Gly Phe Leu Ser Asp Leu Leu Lys Lys Ala Asn 
     130                135                140
Arg Pro Tyr Asp Glu Pro Lys Leu Gln Glu Tyr Thr Gln Thr Ile Leu 
 145                150                155                160
Arg Met Phe Asp Leu Asn Gly Asp Gly Lys Leu Gly Leu Ser Glu Met 
                 165                170                175
Ser Arg Leu Leu Pro Val Gln Glu Asn Phe Leu Leu Lys Phe Gln Gly 
             180                185                190
Met Lys Leu Thr Ser Glu Glu Phe Asn Ala Ile Phe Thr Phe Tyr Asp 
         195                200                205
Lys Asp Arg Ser Gly Tyr Ile Asp Glu His Glu Leu Asp Ala Leu Leu 
     210                215                220
Lys Asp Leu Tyr Glu Lys Asn Lys Lys Glu Ile Asn Ile Gln Gln Leu 
 225                230                235                240
Thr Asn Tyr Arg Lys Ser Val Met Ser Leu Ala Glu Ala Gly Lys Leu 
                 245                250                255
Tyr Arg Lys Asp Leu Glu Ile Val Leu Cys Ser Glu Pro Pro Met 
             260                265                270



<210> 9926
<211> 1449
<212> DNA
<213> Rattus norvegicus
<308> X66974
<400> 9926

gggcggcac  gagtgacag  gctgagagg  ttaagatct  cggagccgc  cgccatggc  60
ggcccgcag  agcagcccc  ttacctgca  ctggccgag  tgactgcat  ccagttcct  120
gaaatctgg  agcactttg  tgctgacgg  aatgggtac  ttgaaggta  agagctaga  180
aacttcttc  aggagctgg  gaaggcaag  aaaggttct  gcatgatgt  caagagcga  240
aattttgga  agaagatga  ggagttcat  cagaagtat  ataagaact  agatgggaa  300
attgagatg  cagagctgg  gcagatcct  ccaaccgaa  agaatttcc  tttgtgctt  360
aggcagcac  tgggctcca  cgctgagtt  atggaggct  ggcggaagt  tgacacaga  420
agaagtggc  acatcgaag  aaatgagct  aagggattt  tgtccgacc  cctgaagaa  480
gccaaccgt  cctatgatg  acctaagct  caggagtac  cccaaacca  actacgcat  540
tttgactta  atggagacg  caaattggg  ctctcagag  tgtctagac  cttgcctgt  600
caagaaaac  tcctgctga  atttcaggg  atgaagctg  cctcagaag  gttcaatgc  660
atcttcaca  tctatgaca  ggatggaag  ggctacatc  atgagaacg  gctggacgc  720
ctcctgaag  atctgtatg  gaagaacaa  aaggagatg  atatccagc  gctcaccac  780
tacaggaag  gcgtcatgt  cttggccga  gcagggaaa  tctacagaa  ggacctgga  840
attgtgctt  gcagtgagc  ccccatgta  aggggtgaa  ggacagggg  tgcttctgc  900
cctccccta  accctgccc  ccactgccc  gactctctt  aaactcctt  ccagacctc  960
ccacccctg  aacctgcac  caccagcct  tggggcagg  aaggagaga  ggaaagagg  1020
tggctggta  cattccttt  agctgcacc  gcccaaccc  ggcctgaca  acagctgtg  1080
ctgtggtgg  tgggtcaca  ggttggtgg  taggggcac  ggtggggct  ccctagtct  1140
tttgctgtg  tgcatgagc  cctcgctgt  tgattagct  ccgagtcca  cagagtgca  1200
tccttcctc  tgctgcacc  gcctccttc  ccccaggcc  cccactgac  cccgcaatt  1260
caggttctg  ccaccggct  gctaatgat  taactgtct  ctcagagct  ctgtggagg  1320
tcattgccc  cttcttgtg  tcttgactt  tgtgttcct  ttattttgg  gtttccctg  1380
cttctcgtt  accaaagaa  agtttacag  gaataaagt  gaaatgtcc  gccgtgaaa  1440
aaaaaaaaa  1449



<210> 9927
<211> 271
<212> PRT
<213> Rattus norvegicus
<308> P47728
<400> 9927

Met Ala Gly Pro Gln Gln Gln Pro Pro Tyr Leu His Leu Ala Glu Leu 
  1               5                  10                  15
Thr Ala Ser Gln Phe Leu Glu Ile Trp Lys His Phe Asp Ala Asp Gly 
             20                  25                  30
Asn Gly Tyr Ile Glu Gly Lys Glu Leu Glu Asn Phe Phe Gln Glu Leu 
         35                  40                  45
Glu Lys Ala Arg Lys Gly Ser Gly Met Met Ser Lys Ser Asp Asn Phe 
     50                  55                  60
Gly Glu Lys Met Lys Glu Phe Met Gln Lys Tyr Asp Lys Asn Ser Asp 
 65                  70                  75                  80
Gly Lys Ile Glu Met Ala Glu Leu Ala Gln Ile Leu Pro Thr Glu Glu 
                 85                  90                  95
Asn Phe Leu Leu Cys Phe Arg Gln His Val Gly Ser Ser Ala Glu Phe 
             100                105                110
Met Glu Ala Trp Arg Lys Tyr Asp Thr Asp Arg Ser Gly Tyr Ile Glu 
         115                120                125
Ala Asn Glu Leu Lys Gly Phe Leu Ser Asp Leu Leu Lys Lys Ala Asn 
     130                135                140
Arg Pro Tyr Asp Glu Pro Lys Leu Gln Glu Tyr Thr Gln Thr Ile Leu 
 145                150                155                160
Arg Met Phe Asp Leu Asn Gly Asp Gly Lys Leu Gly Leu Ser Glu Met 
                 165                170                175
Ser Arg Leu Leu Pro Val Gln Glu Asn Phe Leu Leu Lys Phe Gln Gly 
             180                185                190
Met Lys Leu Thr Ser Glu Glu Phe Asn Ala Ile Phe Thr Phe Tyr Asp 
         195                200                205
Lys Asp Gly Ser Gly Tyr Ile Asp Glu Asn Glu Leu Asp Ala Leu Leu 
     210                215                220
Lys Asp Leu Tyr Glu Lys Asn Lys Lys Glu Met Asn Ile Gln Gln Leu 
 225                230                235                240
Thr Thr Tyr Arg Lys Ser Val Met Ser Leu Ala Glu Ala Gly Lys Leu 
                 245                250                255
Tyr Arg Lys Asp Leu Glu Ile Val Leu Cys Ser Glu Pro Pro Met 
             260                265                270



<210> 9928
<211> 1413
<212> DNA
<213> Homo sapiens
<308> NM_007087
<400> 9928

agcgcgagt  ccagagccc  gccggcgcg  agcgggagc  gtgcaggct  aggtctccg  60
gcggctcgc  atggctggc  cgcagcagc  gccccctta  ctgcacctg  ccgagctga  120
ggcgtccca  ttcctggaa  tatggaagc  ctttgacgc  gacggaaat  ggtatattg  180
aggtaaaga  ctagaaaac  ttttccaag  gctggagaa  gcaaggaaa  gctctggca  240
gatgtcaaa  agtgacaac  ttggagaaa  gatgaagga  ttcatgcag  agtatgata  300
aaactcaga  gggaaaatc  agatggcag  gctggcgca  atcctgcca  ccgaagaga  360
cttccttct  tgcttcagg  agcacgtgg  ctccagcgc  gagtttatg  aggcttggc  420
gaagtacga  acagacagg  gtggctaca  cgaagccaa  gagctcaag  gattcctgt  480
agacctgct  aagaaggcg  accggccgt  cgatgagcc  aagctccag  aatacaccc  540
aaccatact  cggatgttt  acttgaacg  ggatggcaa  ttgggcctc  cagagatgt  600
ccgggcatg  agctgacct  agaggagtt  aacgcgatc  tcacatttt  cgacaagga  660
agaagcggc  acattgacg  gcatgagct  gatgccctt  tgaaggatc  gtacgagaa  720
aacaaaaag  aaatcaata  tcaacagct  accaactac  gaaagagcg  catgtcctt  780
gcagaggca  ggaagctct  ccgcaagga  ctggagatt  tgctctgca  cgagccccc  840
atgtaaagt  gggacgggg  ctgcttctc  acctccccc  aaccctgct  ctgctgccc  900
gatgcgtct  cccagactc  gagaccgtg  gcgccccgc  cccacccct  cagcctgca  960
acacctgcc  gcagagcag  aaacgagag  tagaggatg  gcagctggg  ggctgtcct  1020
agccccctg  acccacccc  gcccaggca  tctttgctc  gtggatcac  cacatggaa  1080
gtgatgggg  catgggtgg  gggtcccta  ttctcttcg  tgtgatgca  gagctccct  1140
gctgtatga  ttaggcttc  atgtccaac  gagtggact  ttccctctc  ctcccctct  1200
ccggtcccc  atgccacca  ccaccccaa  cttccaggt  ccatccacc  ccttgccaa  1260
ggtgtagct  tcctctcag  actcctgtg  gtggaaggc  cccgccctt  ccttgcctt  1320
tttactcgg  gtgctcctt  tctctttgg  tttcttgtt  accaaagaa  agtttacag  1380
caataaaat  gaaaggtcc  gctgtggaa  ctt  1413



<210> 9929
<211> 271
<212> PRT
<213> Homo sapiens
<308> P22676
<400> 9929

Met Ala Gly Pro Gln Gln Gln Pro Pro Tyr Leu His Leu Ala Glu Leu 
  1               5                  10                  15
Thr Ala Ser Gln Phe Leu Glu Ile Trp Lys His Phe Asp Ala Asp Gly 
             20                  25                  30
Asn Gly Tyr Ile Glu Gly Lys Glu Leu Glu Asn Phe Phe Gln Glu Leu 
         35                  40                  45
Glu Lys Ala Arg Lys Gly Ser Gly Met Met Ser Lys Ser Asp Asn Phe 
     50                  55                  60
Gly Glu Lys Met Lys Glu Phe Met Gln Lys Tyr Asp Lys Asn Ser Asp 
 65                  70                  75                  80
Gly Lys Ile Glu Met Ala Glu Leu Ala Gln Ile Leu Pro Thr Glu Glu 
                 85                  90                  95
Asn Phe Leu Leu Cys Phe Arg Gln His Val Gly Ser Ser Ala Glu Phe 
             100                105                110
Met Glu Ala Trp Arg Lys Tyr Asp Thr Asp Arg Ser Gly Tyr Ile Glu 
         115                120                125
Ala Asn Glu Leu Lys Gly Phe Leu Ser Asp Leu Leu Lys Lys Ala Asn 
     130                135                140
Arg Pro Tyr Asp Glu Pro Lys Leu Gln Glu Tyr Thr Gln Thr Ile Leu 
 145                150                155                160
Arg Met Phe Asp Leu Asn Gly Asp Gly Lys Leu Gly Leu Ser Glu Met 
                 165                170                175
Ser Arg Leu Leu Pro Val Gln Glu Asn Phe Leu Leu Lys Phe Gln Gly 
             180                185                190
Met Lys Leu Thr Ser Glu Glu Phe Asn Ala Ile Phe Thr Phe Tyr Asp 
         195                200                205
Lys Asp Arg Ser Gly Tyr Ile Asp Glu His Glu Leu Asp Ala Leu Leu 
     210                215                220
Lys Asp Leu Tyr Glu Lys Asn Lys Lys Glu Ile Asn Ile Gln Gln Leu 
 225                230                235                240
Thr Asn Tyr Arg Lys Ser Val Met Ser Leu Ala Glu Ala Gly Lys Leu 
                 245                250                255
Tyr Arg Lys Asp Leu Glu Ile Val Leu Cys Ser Glu Pro Pro Met 
             260                265                270



<210> 9930
<211> 1489
<212> DNA
<213> Rattus norvegicus
<308> X67788
<400> 9930

caagattgc  ctgctggag  aggcacgga  gcgcaagga  gacgaggtg  aggagtggc  60
gcaccgggc  aaagaggcc  aggacgacc  ggtgaagac  aaagaggag  tgcacctgg  120
gatgacggc  cccccgccc  cacccccgc  cgtgtacga  cccgtgaat  accacgtgc  180
ggaggggct  caggatgag  gagcagagc  catgggcta  agtgccgag  tctccagcg  240
gggcatcct  gacgaccgt  acgaggaga  gcggatcac  gaggcagag  agaacgagc  300
cgtgcagcg  cagccgttg  ctctgagca  tgagttgtc  caggcccgg  atgagaata  360
gaggaccca  aatgacatc  tccacaatg  gaacatgcg  caaggccgg  acaagtata  420
gacgctgcg  cagatcagg  agggcaaca  caagcagcg  atcgacgag  ttgaggcca  480
gtagaggcc  ggccgggac  aagggcgga  ggcacctca  agcaggcag  tgtcactct  540
ggctcttta  tactctata  gtctagaaa  ccccttgcc  tgttccagt  ccttaaaga  600
caggtaccg  gcgatgttc  gccccaaga  ccagtggaa  cctccctgg  tgcttccaa  660
agtatcaca  agtgccaaa  aggccagat  tttatgaca  ttgccgaat  acttcccgt  720
cggagcagg  attcggagg  ctggcccga  tgacgcgat  cagtgtcac  ggggataat  780
atagcactg  ggctcacac  cgggtgcca  actttctct  gttttacaa  gagctcaaa  840
cgattttgt  cttgatttc  atgaaggat  catctctgt  tgttgaggg  tgaaaatga  900
tttgaaatt  gagtcttaa  acgccccac  cagtctcct  cctccagac  gctggcaga  960
tctcctgcg  tccctcaga  tgtacggta  aggactctc  gatacaaaa  tctcatgct  1020
accctgtta  cattcattg  tggactgat  cacctaatg  tcttctata  agaatagta  1080
ttatatata  gcgataata  gggtttgta  cattagttt  aaaaaggga  agttttgtt  1140
tgtatattt  gttaccttt  acagaataa  agaattcaa  attaagaac  agtaatcac  1200
acacttgat  tgacacggg  gcaggtggg  gaccgatga  cggaatcgc  gctgtacaa  1260
aatgttagt  ggttttgtg  atgtaaaac  cacacttca  cttcctgtc  gttcttcac  1320
gagagcagt  agactctag  ccgaaggga  tcaggcctg  ttattgtga  caacttgtt  1380
ctgttttca  tttgtcttc  ttccttgag  cggactgtc  tttttggtt  tgatgtcct  1440
tgcaggtca  tccgcacca  atttacaca  aataaaagt  ctccaaggc  1489



<210> 9931
<211> 160
<212> PRT
<213> Rattus norvegicus
<308> P31977
<400> 9931

Lys Ile Ala Leu Leu Glu Glu Ala Arg Arg Arg Lys Glu Asp Glu Val 
  1               5                  10                  15
Glu Glu Trp Gln His Arg Ala Lys Glu Ala Gln Asp Asp Leu Val Lys 
             20                  25                  30
Thr Lys Glu Glu Leu His Leu Val Met Thr Ala Pro Pro Pro Pro Pro 
         35                  40                  45
Pro Pro Val Tyr Glu Pro Val Asn Tyr His Val Gln Glu Gly Leu Gln 
     50                  55                  60
Asp Glu Gly Ala Glu Pro Met Gly Tyr Ser Ala Glu Leu Ser Ser Glu 
 65                  70                  75                  80
Gly Ile Leu Asp Asp Arg Asn Glu Glu Lys Arg Ile Thr Glu Ala Glu 
                 85                  90                  95
Lys Asn Glu Arg Val Gln Arg Gln Pro Leu Thr Leu Ser Asn Glu Leu 
             100                105                110
Ser Gln Ala Arg Asp Glu Asn Lys Arg Thr His Asn Asp Ile Ile His 
         115                120                125
Asn Glu Asn Met Arg Gln Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln 
     130                135                140
Ile Arg Gln Gly Asn Thr Lys Gln Arg Ile Asp Glu Phe Glu Ala Met 
 145                150                155                160



<210> 9932
<211> 3044
<212> DNA
<213> Homo sapiens
<308> X51521
<400> 9932

aggcagggc  ggcgggcgc  ctaagggtt  tgctctgac  ccaggttgg  acagcgtct  60
cgctgctgc  ggatagtcg  gttttcggg  atcgaggat  ctcaccaga  accgaaaat  120
ccgaaacca  tcaatgtcc  agttaccac  atggatgca  agctggagt  tgcaatcca  180
ccaaataca  ctggaaaac  gctttttga  caggtggta  agactatcg  cctccggga  240
gtgtggtac  ttggcctcc  ctatgtgga  aataaagga  ttcctacct  gctgaagct  300
gataagaag  tgtctgccc  ggaggtcag  aaggagaat  ccctccagt  caagttccg  360
gccaagttc  accctgaag  tgtggctga  gagctcatc  aggacatca  ccagaaact  420
ttcttcctc  aagtgaagg  aggaatcct  agcgatgag  tctactgcc  ccctgagac  480
gccgtgctc  tggggtcct  cgctgtgca  gccaagttt  gggactaca  caaagaagt  540
cacaagtct  ggtacctca  ctctgagcg  ctgatccct  aaagagtga  ggaccagca  600
aaacttacc  gggaccagt  ggaggaccg  atccaggtg  ggcatgcgg  acaccgtgg  660
atgctcaaa  ataatgcta  gttggaata  ctgaagatt  ctcaggacc  ggaaatgta  720
ggaatcaac  atttcgaga  aaaaaacaa  aaaggaaca  acctttggc  tggagttga  780
gcccttgga  tgaatattt  tgagaaaga  gataagtta  ccccaaaga  tggctttcc  840
tggagtgaa  tcaggaaca  ctctttcaa  gacaaaaag  ttgtcatta  acccatcga  900
aagaaggca  ctgactttg  gttttatgc  ccacgtctg  gaatcaaca  gcggatcct  960
cagctctgc  tgggcaacc  tgagttgta  atgcgccgc  ggaagcctg  caccatcga  1020
gtgcagcag  tgaaggccc  ggcccggga  gagaagcat  agaagcagc  ggagcggca  1080
cagctggaa  cagagaaga  aaggagaga  accgtggag  gagagaaag  gcagatgat  1140
cgcgagaag  aggagttga  gctgcggct  caggactat  aggagaaga  aaagaaggc  1200
gagagagag  tctcggagc  gattcagag  gccctgcag  tggaggagg  gaggaagcg  1260
gcacaggag  aggccgagc  cctagaggc  gaccgtatg  ctgcactgc  ggctaagga  1320
gagctggag  gacaggcgg  ggatcagat  aagagccag  agcagctgg  tgcggagct  1380
gcagaatac  cagccaaga  tgccctcct  gaagaggcg  ggaggcgca  ggaggatga  1440
gttgaagag  ggcagcaca  ggccaaaga  gcccaggat  acctggtga  gaccaagga  1500
gagctgcac  tggtgatga  agcaccccc  cccccacca  cccccgtgt  cgagccggt  1560
agctaccat  tccaggaga  cttgcagga  gagggcgca  agcccacgg  ctacagcgc  1620
gagctgtct  gtgagggca  ccgggatga  cgcaatgag  agaagcgca  cactgaggc  1680
gagaagaac  agcgtgtgc  gcggcagct  gtgacgctg  gcagcgagc  gtcccaggc  1740
cgagatgag  ataagagga  ccacaatga  atcatccac  acgagaaca  gaggcaagg  1800
cgggacaag  acaagacgc  gcggcagat  cggcagggc  acaccaagc  gcgcatcga  1860
gagttcgag  ccctgtaac  gccaggcca  gaccaaggg  agaggggtg  tcatagcgg  1920
cgctgccag  cccgccacg  ttgtcttta  tgctccaag  ctaggaact  cctcagatc  1980
cagttcctt  agaaagcag  tacccaaca  aaacattct  ggctgggaa  cagggaggc  2040
ccctggttt  ttttcccca  ttgtaatag  gccaagcag  cctgattct  gcgattatt  2100
tcgaatcac  tcctgtgtt  tgctgggag  aggactgat  gaattacgg  aaatgcctg  2160
aaagtctga  taagaaact  catgctggc  tgtgtgata  aagagtcag  atcattaaa  2220
gaaacgtgg  aggacttcc  tctgtgcca  acttgttct  tattcgaaa  gagctcaaa  2280
tgatttttt  aatttctat  aaggatcca  ctttgtata  ttacatgct  agaggggtg  2340
aaattattt  ggaaattga  tctgaagca  tctcgcaca  acagtgatt  cctcctccc  2400
tcactccac  cagctggca  agagcacag  gatcaccag  gtgagtggt  gaggaggac  2460
cttggatat  tttttagtt  ttttttttt  ggcttaaca  ttttagaat  cattgtact  2520
atacacctt  ttaatgatc  gctatatac  atttatata  aagtgataa  acagatttg  2580
aacattagt  ttaaaaagg  aaagttttg  tctgtatat  ttgttacct  ttacagaat  2640
aaagaatta  atatgaaaa  ccctctaaa  catggcact  gatgtgatg  ggcaggagg  2700
nagtggtgg  gctggacct  cctgctgca  ctgcagtca  gtgtaaaca  gattattat  2760
agtgtttta  gcatgtaat  gactatgca  acttttaat  ttgtcagat  cacacatgc  2820
actatgagc  ttcagactc  agctgtgaa  agactctgt  tgcttgtgt  tgtttgcag  2880
ctctctctg  catggcctt  gcaggctgc  ggaaggcag  ttgtggagg  cgttggttc  2940
gcccactca  tccttctcg  gcactgctt  ctccttcac  gctaagatg  catgtgcag  3000
tggattcca  gccgcagac  tgaaataaa  gctttgcaa  ggca  3044



<210> 9933
<211> 585
<212> PRT
<213> Homo sapiens
<308> P15311
<400> 9933

Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu Glu 
  1               5                  10                  15
Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln Val 
             20                  25                  30
Val Lys Thr Ile Gly Leu Arg Glu Val Trp Tyr Phe Gly Leu His Tyr 
         35                  40                  45
Val Asp Asn Lys Gly Phe Pro Thr Trp Leu Lys Leu Asp Lys Lys Val 
     50                  55                  60
Ser Ala Gln Glu Val Arg Lys Glu Asn Pro Leu Gln Phe Lys Phe Arg 
 65                  70                  75                  80
Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu Glu Leu Ile Gln Asp Ile 
                 85                  90                  95
Thr Gln Lys Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Ser Asp 
             100                105                110
Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Gly Ser Tyr Ala 
         115                120                125
Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys Glu Val His Lys Ser Gly 
     130                135                140
Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln Arg Val Met Asp Gln His 
 145                150                155                160
Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg Ile Gln Val Trp His Ala 
                 165                170                175
Glu His Arg Gly Met Leu Lys Asp Asn Ala Met Leu Glu Tyr Leu Lys 
             180                185                190
Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile Asn Tyr Phe Glu Ile Lys 
         195                200                205
Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly Leu 
     210                215                220
Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe Pro 
 225                230                235                240
Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val Ile 
                 245                250                255
Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro Arg 
             260                265                270
Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His Glu 
         275                280                285
Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln Met 
     290                295                300
Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg Gln 
 305                310                315                320
Gln Leu Glu Thr Glu Lys Lys Arg Arg Glu Thr Val Glu Arg Glu Lys 
                 325                330                335
Glu Gln Met Met Arg Glu Lys Glu Glu Leu Met Leu Arg Leu Gln Asp 
             340                345                350
Tyr Glu Glu Lys Thr Lys Lys Ala Glu Arg Glu Leu Ser Glu Gln Ile 
         355                360                365
Gln Arg Ala Leu Gln Leu Glu Glu Glu Arg Lys Arg Ala Gln Glu Glu 
     370                375                380
Ala Glu Arg Leu Glu Ala Asp Arg Met Ala Ala Leu Arg Ala Lys Glu 
 385                390                395                400
Glu Leu Glu Arg Gln Ala Val Asp Gln Ile Lys Ser Gln Glu Gln Leu 
                 405                410                415
Ala Ala Glu Leu Ala Glu Tyr Thr Ala Lys Ile Ala Leu Leu Glu Glu 
             420                425                430
Ala Arg Arg Arg Lys Glu Asp Glu Val Glu Glu Trp Gln His Arg Ala 
         435                440                445
Lys Glu Ala Gln Asp Asp Leu Val Lys Thr Lys Glu Glu Leu His Leu 
     450                455                460
Val Met Thr Ala Pro Pro Pro Pro Pro Pro Pro Val Tyr Glu Pro Val 
 465                470                475                480
Ser Tyr His Val Gln Glu Ser Leu Gln Asp Glu Gly Ala Glu Pro Thr 
                 485                490                495
Gly Tyr Ser Ala Glu Leu Ser Ser Glu Gly Ile Arg Asp Asp Arg Asn 
             500                505                510
Glu Glu Lys Arg Ile Thr Glu Ala Glu Lys Asn Glu Arg Val Gln Arg 
         515                520                525
Gln Leu Val Thr Leu Ser Ser Glu Leu Ser Gln Ala Arg Asp Glu Asn 
     530                535                540
Lys Arg Thr His Asn Asp Ile Ile His Asn Glu Asn Met Arg Gln Gly 
 545                550                555                560
Arg Asp Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly Asn Thr Lys 
                 565                570                575
Gln Arg Ile Asp Glu Phe Glu Ala Leu 
             580                585



<210> 9934
<211> 1521
<212> DNA
<213> Rattus norvegicus
<308> X67859
<400> 9934

gaatctttg  gtgtgagaa  ctttacaga  agccacaat  gctgaaaat  gagataacg  60
aaaaatggc  gctctggag  ccaaaatct  tcatcaaat  gagtattat  ttggagact  120
caatttgcc  cgagacaag  ttttaaaag  acagatcaa  ttggatgaa  gctgggtac  180
tttggaaac  atgataaaa  tcaacaggc  aaaccgact  acaacagac  ttaatgtaa  240
cgtgcaagc  ttgagcaaa  ctaaggcaa  tctcatgga  gtgagtgca  acaaaacta  300
aattagaag  tcaccaagc  gaccactcc  tgaagtgac  gatgagtat  agaatgatg  360
gaaaaatag  tctgtttat  ttaaaggct  cccaactga  gccaccctt  atgatataa  420
agaatggct  gatgataaa  gccaaatac  gaatattca  atgagaaga  cattgcaca  480
aacatttaa  gggtcaata  ttgctgtgt  tgatagtat  cagtctgca  agaagtttg  540
ggacacccc  ggccagaag  acaaagaca  taatctgct  atactcttc  aggaagatt  600
ctttgcaaa  aaaaatgaa  aaagaaagc  gagcaaagt  gaagctaaa  taaaagcta  660
acaagaaca  gaaggacga  acaaaccag  aagtactga  acaagagct  tagaaggaa  720
aatgggatg  ttactgaag  tttcaggtg  cttggatga  cagacctgt  gagaagatt  780
ccacttcct  ttctcaaat  atggtgaaa  aaaatggat  gactttgtc  gaggagcaa  840
agagggaat  attctcttc  aagaaaagg  taaggacgc  cttgagaaa  ccagaagtg  900
aaataatgg  aacctactg  taaggaaca  aaaagtgac  tggaaagta  tagaaggac  960
tgcagaaaa  gatgcaatg  aaaaaatca  agatgatca  caagaatct  tgaacaaat  1020
gaagtcaaa  ggaggtcat  cagcccgca  atttaaagg  agtcatgtt  ttacagcag  1080
tcgcagatt  aaaggaaga  ggaaaggta  tagacctgc  tatgctggg  cacccaaag  1140
aagaggaca  tttcaagga  ggaggacaa  atttgatga  gatgatcat  gtcgtggac  1200
agtgaaaag  ggaatagac  gaagagaca  agaagaacc  gcatcaaag  ataagaaaa  1260
agagaatgg  gctagagac  agtagttta  ttagtaagc  gtgttttta  tccttagtt  1320
ggttttaag  tgctttttg  cttcagaag  ttttaaaag  aaagcgaat  aggccactt  1380
aatgtccac  tgtataaaa  gaaaagttt  ttgttttac  tgtcttttt  ttgttatcc  1440
aatgaaagt  ttttaaaat  tatagttct  tttgtgttt  gatgattaa  atatgaaaa  1500
gaaaaaaaa  aaaaaaaaa  a  1521



<210> 9935
<211> 415
<212> PRT
<213> Rattus norvegicus
<308> P38656
<400> 9935

Met Ala Glu Asn Gly Asp Asn Glu Lys Met Ala Ala Leu Glu Ala Lys 
  1               5                  10                  15
Ile Cys His Gln Ile Glu Tyr Tyr Phe Gly Asp Phe Asn Leu Pro Arg 
             20                  25                  30
Asp Lys Phe Leu Lys Glu Gln Ile Lys Leu Asp Glu Gly Trp Val Pro 
         35                  40                  45
Leu Glu Thr Met Ile Lys Phe Asn Arg Leu Asn Arg Leu Thr Thr Asp 
     50                  55                  60
Phe Asn Val Ile Val Gln Ala Leu Ser Lys Ser Lys Ala Asn Leu Met 
 65                  70                  75                  80
Glu Val Ser Ala Asp Lys Thr Lys Ile Arg Arg Ser Pro Ser Arg Pro 
                 85                  90                  95
Leu Pro Glu Val Thr Asp Glu Tyr Lys Asn Asp Val Lys Asn Arg Ser 
             100                105                110
Val Tyr Ile Lys Gly Phe Pro Thr Asp Ala Thr Leu Asp Asp Ile Lys 
         115                120                125
Glu Trp Leu Asp Asp Lys Gly Gln Ile Leu Asn Ile Gln Met Arg Arg 
     130                135                140
Thr Leu His Lys Thr Phe Lys Gly Ser Ile Phe Ala Val Phe Asp Ser 
 145                150                155                160
Ile Gln Ser Ala Lys Lys Phe Val Asp Thr Pro Gly Gln Lys Tyr Lys 
                 165                170                175
Asp Thr Asn Leu Leu Ile Leu Phe Lys Glu Asp Tyr Phe Ala Lys Lys 
             180                185                190
Asn Glu Glu Arg Lys Gln Ser Lys Val Glu Ala Lys Leu Lys Ala Lys 
         195                200                205
Gln Glu His Glu Gly Arg His Lys Pro Gly Ser Thr Glu Thr Arg Ala 
     210                215                220
Leu Glu Gly Lys Met Gly Cys Leu Leu Lys Phe Ser Gly Asp Leu Asp 
 225                230                235                240
Asp Gln Thr Cys Arg Glu Asp Phe His Phe Leu Phe Ser Asn His Gly 
                 245                250                255
Glu Ile Lys Trp Ile Asp Phe Val Arg Gly Ala Lys Glu Gly Ile Ile 
             260                265                270
Leu Phe Lys Glu Lys Ala Lys Asp Ala Leu Glu Lys Ala Arg Ser Ala 
         275                280                285
Asn Asn Gly Asn Leu Leu Leu Arg Asn Lys Lys Val Thr Trp Lys Val 
     290                295                300
Leu Glu Gly His Ala Glu Lys Asp Ala Met Lys Lys Ile Thr Asp Asp 
 305                310                315                320
Gln Gln Glu Ser Leu Asn Lys Trp Lys Ser Lys Gly Gly His Ala Ala 
                 325                330                335
Arg Arg Phe Lys Gly Ser His Val Phe Thr Ala Ala Arg Arg Phe Lys 
             340                345                350
Gly Arg Gly Lys Gly Asn Arg Pro Ala Tyr Ala Gly Ala Pro Lys Gly 
         355                360                365
Arg Gly Gln Phe Gln Gly Arg Arg Thr Arg Phe Asp Asp Asp Asp His 
     370                375                380
Arg Arg Gly Pro Val Lys Arg Gly Ile Asp Gly Arg Asp Arg Glu Glu 
 385                390                395                400
Pro Ala Ser Lys His Lys Lys Arg Glu Asn Gly Ala Arg Asp Lys 
                 405                410                415



<210> 9936
<211> 1619
<212> DNA
<213> Homo sapiens
<308> NM_003142
<400> 9936

ggagtcgtt  ttgttgctg  ttgtgagcc  gtgcggcgg  ttctgtggg  cggaacctt  60
aagatagcc  caatggctg  aaatggtga  aatgaaaag  tggctgccc  ggaggccaa  120
atctgtcat  aaattgagt  ttattttgg  gacttcaat  tgccacggg  caagtttct  180
aaggaacag  taaaactgg  tgaaggctg  gtacctttg  agataatga  aaaattcaa  240
aggttgaac  gtctaacaa  agactttaa  gtaattgtg  aagcattga  caaatccaa  300
gcagaactc  tggaaatca  tgaagataa  actaaaatc  gaaggtctc  aagcaaacc  360
ctacctgaa  tgactgatg  gtataaaaa  gatgtaaaa  acagatctg  ttatattaa  420
ggcttccca  ctgatgcaa  tcttgatga  ataaaagaa  ggttagaag  taaaggtca  480
gtactaaat  ttcagatga  aagaacatt  cataaagca  ttaagggat  aatttttgt  540
gtgtttgat  gcattgaat  tgctaagaa  tttgtagag  cccctggcc  gaagtacaa  600
gaaacagac  tgctaatac  tttcaagga  gattacttt  ccaaaaaaa  tgaagaaag  660
aaacaaaat  aagtggaag  taaattaag  gctaaacag  agcaagaag  aaaacaaaa  720
ttagaagaa  atgctgaaa  gaaatctct  gaagaaaag  ttggatgct  gctgaaatt  780
tcgggtgat  tagatgatc  gacctgtag  gaagattta  acatacttt  ctcaaatca  840
ggtgaaata  aatggatag  cttcgtcag  ggagcaaaa  aggggataa  tctatttaa  900
gaaaaagcc  aggaagcat  gggtaaagc  aaagatgca  ataatggta  cctacaatt  960
aggaacaaa  aagtgactt  ggaagtact  gaaggagag  tggaaaaag  agcactgaa  1020
aaaataata  aagaccaac  agaatccct  aacaaatgg  agtcaaaag  tcgtagatt  1080
aaaggaaaa  gaaagggta  taaagctgc  cagcctggg  ctggtaaag  aaaagtaca  1140
tttcagggc  agaaaacga  atttgctag  gatgatgaa  atgatgaac  tgatgaaaa  1200
ggtgcaact  gacctgtga  aagagcaag  gaagaaaca  acaaagaag  acctgcatc  1260
aaacaacag  aaacagaaa  tggtgctgg  gaccagtag  ttagtaaac  aatttttta  1320
tcattttaa  taggtttta  acgactttt  tttgcgggg  ttttaaaag  aaaaccgaa  1380
taggtccac  tcaatgtcc  cctgtgaga  aggaaaaat  tttttgttg  ttaacttgt  1440
tttttgtta  gcaaatgag  tttctttga  tgtattgtt  tgtttgtgt  atttcagat  1500
attcaaata  caaaaggaa  attcttcca  taaattgcc  ttgtaatat  agaatgtat  1560
agtacaaac  aactaataa  atatatact  tatgaaaag  gcaaaaaaa  aaaaaaaaa  1619



<210> 9937
<211> 408
<212> PRT
<213> Homo sapiens
<308> P05455
<400> 9937

Met Ala Glu Asn Gly Asp Asn Glu Lys Met Ala Ala Leu Glu Ala Lys 
  1               5                  10                  15
Ile Cys His Gln Ile Glu Tyr Tyr Phe Gly Asp Phe Asn Leu Pro Arg 
             20                  25                  30
Asp Lys Phe Leu Lys Glu Gln Ile Lys Leu Asp Glu Gly Trp Val Pro 
         35                  40                  45
Leu Glu Ile Met Ile Lys Phe Asn Arg Leu Asn Arg Leu Thr Thr Asp 
     50                  55                  60
Phe Asn Val Ile Val Glu Ala Leu Ser Lys Ser Lys Ala Glu Leu Met 
 65                  70                  75                  80
Glu Ile Ser Glu Asp Lys Thr Lys Ile Arg Arg Ser Pro Ser Lys Pro 
                 85                  90                  95
Leu Pro Glu Val Thr Asp Glu Tyr Lys Asn Asp Val Lys Asn Arg Ser 
             100                105                110
Val Tyr Ile Lys Gly Phe Pro Thr Asp Ala Thr Leu Asp Asp Ile Lys 
         115                120                125
Glu Trp Leu Glu Asp Lys Gly Gln Val Leu Asn Ile Gln Met Arg Arg 
     130                135                140
Thr Leu His Lys Ala Phe Lys Gly Ser Ile Phe Val Val Phe Asp Ser 
 145                150                155                160
Ile Glu Ser Ala Lys Lys Phe Val Glu Thr Pro Gly Gln Lys Tyr Lys 
                 165                170                175
Glu Thr Asp Leu Leu Ile Leu Phe Lys Asp Asp Tyr Phe Ala Lys Lys 
             180                185                190
Asn Glu Glu Arg Lys Gln Asn Lys Val Glu Ala Lys Leu Arg Ala Lys 
         195                200                205
Gln Glu Gln Glu Ala Lys Gln Lys Leu Glu Glu Asp Ala Glu Met Lys 
     210                215                220
Ser Leu Glu Glu Lys Ile Gly Cys Leu Leu Lys Phe Ser Gly Asp Leu 
 225                230                235                240
Asp Asp Gln Thr Cys Arg Glu Asp Leu His Ile Leu Phe Ser Asn His 
                 245                250                255
Gly Glu Ile Lys Trp Ile Asp Phe Val Arg Gly Ala Lys Glu Gly Ile 
             260                265                270
Ile Leu Phe Lys Glu Lys Ala Lys Glu Ala Leu Gly Lys Ala Lys Asp 
         275                280                285
Ala Asn Asn Gly Asn Leu Gln Leu Arg Asn Lys Glu Val Thr Trp Glu 
     290                295                300
Val Leu Glu Gly Glu Val Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu 
 305                310                315                320
Asp Gln Gln Glu Ser Leu Asn Lys Trp Lys Ser Lys Gly Arg Arg Phe 
                 325                330                335
Lys Gly Lys Gly Lys Gly Asn Lys Ala Ala Gln Pro Gly Ser Gly Lys 
             340                345                350
Gly Lys Val Gln Phe Gln Gly Lys Lys Thr Lys Phe Ala Ser Asp Asp 
         355                360                365
Glu His Asp Glu His Asp Glu Asn Gly Ala Thr Gly Pro Val Lys Arg 
     370                375                380
Ala Arg Glu Glu Thr Asp Lys Glu Glu Pro Ala Ser Lys Gln Gln Lys 
 385                390                395                400
Thr Glu Asn Gly Ala Gly Asp Gln 
                 405



<210> 9938
<211> 1521
<212> DNA
<213> Rattus norvegicus
<308> X67859
<400> 9938

gaatctttg  gtgtgagaa  ctttacaga  agccacaat  gctgaaaat  gagataacg  60
aaaaatggc  gctctggag  ccaaaatct  tcatcaaat  gagtattat  ttggagact  120
caatttgcc  cgagacaag  ttttaaaag  acagatcaa  ttggatgaa  gctgggtac  180
tttggaaac  atgataaaa  tcaacaggc  aaaccgact  acaacagac  ttaatgtaa  240
cgtgcaagc  ttgagcaaa  ctaaggcaa  tctcatgga  gtgagtgca  acaaaacta  300
aattagaag  tcaccaagc  gaccactcc  tgaagtgac  gatgagtat  agaatgatg  360
gaaaaatag  tctgtttat  ttaaaggct  cccaactga  gccaccctt  atgatataa  420
agaatggct  gatgataaa  gccaaatac  gaatattca  atgagaaga  cattgcaca  480
aacatttaa  gggtcaata  ttgctgtgt  tgatagtat  cagtctgca  agaagtttg  540
ggacacccc  ggccagaag  acaaagaca  taatctgct  atactcttc  aggaagatt  600
ctttgcaaa  aaaaatgaa  aaagaaagc  gagcaaagt  gaagctaaa  taaaagcta  660
acaagaaca  gaaggacga  acaaaccag  aagtactga  acaagagct  tagaaggaa  720
aatgggatg  ttactgaag  tttcaggtg  cttggatga  cagacctgt  gagaagatt  780
ccacttcct  ttctcaaat  atggtgaaa  aaaatggat  gactttgtc  gaggagcaa  840
agagggaat  attctcttc  aagaaaagg  taaggacgc  cttgagaaa  ccagaagtg  900
aaataatgg  aacctactg  taaggaaca  aaaagtgac  tggaaagta  tagaaggac  960
tgcagaaaa  gatgcaatg  aaaaaatca  agatgatca  caagaatct  tgaacaaat  1020
gaagtcaaa  ggaggtcat  cagcccgca  atttaaagg  agtcatgtt  ttacagcag  1080
tcgcagatt  aaaggaaga  ggaaaggta  tagacctgc  tatgctggg  cacccaaag  1140
aagaggaca  tttcaagga  ggaggacaa  atttgatga  gatgatcat  gtcgtggac  1200
agtgaaaag  ggaatagac  gaagagaca  agaagaacc  gcatcaaag  ataagaaaa  1260
agagaatgg  gctagagac  agtagttta  ttagtaagc  gtgttttta  tccttagtt  1320
ggttttaag  tgctttttg  cttcagaag  ttttaaaag  aaagcgaat  aggccactt  1380
aatgtccac  tgtataaaa  gaaaagttt  ttgttttac  tgtcttttt  ttgttatcc  1440
aatgaaagt  ttttaaaat  tatagttct  tttgtgttt  gatgattaa  atatgaaaa  1500
gaaaaaaaa  aaaaaaaaa  a  1521



<210> 9939
<211> 415
<212> PRT
<213> Rattus norvegicus
<308> P38656
<400> 9939

Met Ala Glu Asn Gly Asp Asn Glu Lys Met Ala Ala Leu Glu Ala Lys 
  1               5                  10                  15
Ile Cys His Gln Ile Glu Tyr Tyr Phe Gly Asp Phe Asn Leu Pro Arg 
             20                  25                  30
Asp Lys Phe Leu Lys Glu Gln Ile Lys Leu Asp Glu Gly Trp Val Pro 
         35                  40                  45
Leu Glu Thr Met Ile Lys Phe Asn Arg Leu Asn Arg Leu Thr Thr Asp 
     50                  55                  60
Phe Asn Val Ile Val Gln Ala Leu Ser Lys Ser Lys Ala Asn Leu Met 
 65                  70                  75                  80
Glu Val Ser Ala Asp Lys Thr Lys Ile Arg Arg Ser Pro Ser Arg Pro 
                 85                  90                  95
Leu Pro Glu Val Thr Asp Glu Tyr Lys Asn Asp Val Lys Asn Arg Ser 
             100                105                110
Val Tyr Ile Lys Gly Phe Pro Thr Asp Ala Thr Leu Asp Asp Ile Lys 
         115                120                125
Glu Trp Leu Asp Asp Lys Gly Gln Ile Leu Asn Ile Gln Met Arg Arg 
     130                135                140
Thr Leu His Lys Thr Phe Lys Gly Ser Ile Phe Ala Val Phe Asp Ser 
 145                150                155                160
Ile Gln Ser Ala Lys Lys Phe Val Asp Thr Pro Gly Gln Lys Tyr Lys 
                 165                170                175
Asp Thr Asn Leu Leu Ile Leu Phe Lys Glu Asp Tyr Phe Ala Lys Lys 
             180                185                190
Asn Glu Glu Arg Lys Gln Ser Lys Val Glu Ala Lys Leu Lys Ala Lys 
         195                200                205
Gln Glu His Glu Gly Arg His Lys Pro Gly Ser Thr Glu Thr Arg Ala 
     210                215                220
Leu Glu Gly Lys Met Gly Cys Leu Leu Lys Phe Ser Gly Asp Leu Asp 
 225                230                235                240
Asp Gln Thr Cys Arg Glu Asp Phe His Phe Leu Phe Ser Asn His Gly 
                 245                250                255
Glu Ile Lys Trp Ile Asp Phe Val Arg Gly Ala Lys Glu Gly Ile Ile 
             260                265                270
Leu Phe Lys Glu Lys Ala Lys Asp Ala Leu Glu Lys Ala Arg Ser Ala 
         275                280                285
Asn Asn Gly Asn Leu Leu Leu Arg Asn Lys Lys Val Thr Trp Lys Val 
     290                295                300
Leu Glu Gly His Ala Glu Lys Asp Ala Met Lys Lys Ile Thr Asp Asp 
 305                310                315                320
Gln Gln Glu Ser Leu Asn Lys Trp Lys Ser Lys Gly Gly His Ala Ala 
                 325                330                335
Arg Arg Phe Lys Gly Ser His Val Phe Thr Ala Ala Arg Arg Phe Lys 
             340                345                350
Gly Arg Gly Lys Gly Asn Arg Pro Ala Tyr Ala Gly Ala Pro Lys Gly 
         355                360                365
Arg Gly Gln Phe Gln Gly Arg Arg Thr Arg Phe Asp Asp Asp Asp His 
     370                375                380
Arg Arg Gly Pro Val Lys Arg Gly Ile Asp Gly Arg Asp Arg Glu Glu 
 385                390                395                400
Pro Ala Ser Lys His Lys Lys Arg Glu Asn Gly Ala Arg Asp Lys 
                 405                410                415



<210> 9940
<211> 1619
<212> DNA
<213> Homo sapiens
<308> NM_003142
<400> 9940

ggagtcgtt  ttgttgctg  ttgtgagcc  gtgcggcgg  ttctgtggg  cggaacctt  60
aagatagcc  caatggctg  aaatggtga  aatgaaaag  tggctgccc  ggaggccaa  120
atctgtcat  aaattgagt  ttattttgg  gacttcaat  tgccacggg  caagtttct  180
aaggaacag  taaaactgg  tgaaggctg  gtacctttg  agataatga  aaaattcaa  240
aggttgaac  gtctaacaa  agactttaa  gtaattgtg  aagcattga  caaatccaa  300
gcagaactc  tggaaatca  tgaagataa  actaaaatc  gaaggtctc  aagcaaacc  360
ctacctgaa  tgactgatg  gtataaaaa  gatgtaaaa  acagatctg  ttatattaa  420
ggcttccca  ctgatgcaa  tcttgatga  ataaaagaa  ggttagaag  taaaggtca  480
gtactaaat  ttcagatga  aagaacatt  cataaagca  ttaagggat  aatttttgt  540
gtgtttgat  gcattgaat  tgctaagaa  tttgtagag  cccctggcc  gaagtacaa  600
gaaacagac  tgctaatac  tttcaagga  gattacttt  ccaaaaaaa  tgaagaaag  660
aaacaaaat  aagtggaag  taaattaag  gctaaacag  agcaagaag  aaaacaaaa  720
ttagaagaa  atgctgaaa  gaaatctct  gaagaaaag  ttggatgct  gctgaaatt  780
tcgggtgat  tagatgatc  gacctgtag  gaagattta  acatacttt  ctcaaatca  840
ggtgaaata  aatggatag  cttcgtcag  ggagcaaaa  aggggataa  tctatttaa  900
gaaaaagcc  aggaagcat  gggtaaagc  aaagatgca  ataatggta  cctacaatt  960
aggaacaaa  aagtgactt  ggaagtact  gaaggagag  tggaaaaag  agcactgaa  1020
aaaataata  aagaccaac  agaatccct  aacaaatgg  agtcaaaag  tcgtagatt  1080
aaaggaaaa  gaaagggta  taaagctgc  cagcctggg  ctggtaaag  aaaagtaca  1140
tttcagggc  agaaaacga  atttgctag  gatgatgaa  atgatgaac  tgatgaaaa  1200
ggtgcaact  gacctgtga  aagagcaag  gaagaaaca  acaaagaag  acctgcatc  1260
aaacaacag  aaacagaaa  tggtgctgg  gaccagtag  ttagtaaac  aatttttta  1320
tcattttaa  taggtttta  acgactttt  tttgcgggg  ttttaaaag  aaaaccgaa  1380
taggtccac  tcaatgtcc  cctgtgaga  aggaaaaat  tttttgttg  ttaacttgt  1440
tttttgtta  gcaaatgag  tttctttga  tgtattgtt  tgtttgtgt  atttcagat  1500
attcaaata  caaaaggaa  attcttcca  taaattgcc  ttgtaatat  agaatgtat  1560
agtacaaac  aactaataa  atatatact  tatgaaaag  gcaaaaaaa  aaaaaaaaa  1619



<210> 9941
<211> 408
<212> PRT
<213> Homo sapiens
<308> P05455
<400> 9941

Met Ala Glu Asn Gly Asp Asn Glu Lys Met Ala Ala Leu Glu Ala Lys 
  1               5                  10                  15
Ile Cys His Gln Ile Glu Tyr Tyr Phe Gly Asp Phe Asn Leu Pro Arg 
             20                  25                  30
Asp Lys Phe Leu Lys Glu Gln Ile Lys Leu Asp Glu Gly Trp Val Pro 
         35                  40                  45
Leu Glu Ile Met Ile Lys Phe Asn Arg Leu Asn Arg Leu Thr Thr Asp 
     50                  55                  60
Phe Asn Val Ile Val Glu Ala Leu Ser Lys Ser Lys Ala Glu Leu Met 
 65                  70                  75                  80
Glu Ile Ser Glu Asp Lys Thr Lys Ile Arg Arg Ser Pro Ser Lys Pro 
                 85                  90                  95
Leu Pro Glu Val Thr Asp Glu Tyr Lys Asn Asp Val Lys Asn Arg Ser 
             100                105                110
Val Tyr Ile Lys Gly Phe Pro Thr Asp Ala Thr Leu Asp Asp Ile Lys 
         115                120                125
Glu Trp Leu Glu Asp Lys Gly Gln Val Leu Asn Ile Gln Met Arg Arg 
     130                135                140
Thr Leu His Lys Ala Phe Lys Gly Ser Ile Phe Val Val Phe Asp Ser 
 145                150                155                160
Ile Glu Ser Ala Lys Lys Phe Val Glu Thr Pro Gly Gln Lys Tyr Lys 
                 165                170                175
Glu Thr Asp Leu Leu Ile Leu Phe Lys Asp Asp Tyr Phe Ala Lys Lys 
             180                185                190
Asn Glu Glu Arg Lys Gln Asn Lys Val Glu Ala Lys Leu Arg Ala Lys 
         195                200                205
Gln Glu Gln Glu Ala Lys Gln Lys Leu Glu Glu Asp Ala Glu Met Lys 
     210                215                220
Ser Leu Glu Glu Lys Ile Gly Cys Leu Leu Lys Phe Ser Gly Asp Leu 
 225                230                235                240
Asp Asp Gln Thr Cys Arg Glu Asp Leu His Ile Leu Phe Ser Asn His 
                 245                250                255
Gly Glu Ile Lys Trp Ile Asp Phe Val Arg Gly Ala Lys Glu Gly Ile 
             260                265                270
Ile Leu Phe Lys Glu Lys Ala Lys Glu Ala Leu Gly Lys Ala Lys Asp 
         275                280                285
Ala Asn Asn Gly Asn Leu Gln Leu Arg Asn Lys Glu Val Thr Trp Glu 
     290                295                300
Val Leu Glu Gly Glu Val Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu 
 305                310                315                320
Asp Gln Gln Glu Ser Leu Asn Lys Trp Lys Ser Lys Gly Arg Arg Phe 
                 325                330                335
Lys Gly Lys Gly Lys Gly Asn Lys Ala Ala Gln Pro Gly Ser Gly Lys 
             340                345                350
Gly Lys Val Gln Phe Gln Gly Lys Lys Thr Lys Phe Ala Ser Asp Asp 
         355                360                365
Glu His Asp Glu His Asp Glu Asn Gly Ala Thr Gly Pro Val Lys Arg 
     370                375                380
Ala Arg Glu Glu Thr Asp Lys Glu Glu Pro Ala Ser Lys Gln Gln Lys 
 385                390                395                400
Thr Glu Asn Gly Ala Gly Asp Gln 
                 405



<210> 9942
<211> 1526
<212> DNA
<213> Rattus norvegicus
<308> X67877
<400> 9942

ctctcctga  cctgcgcgc  gcgggaaga  ggcgcttga  gctggcgac  tggaagagg  60
acagctttc  gactcggat  ccgacatga  ggtcgtccc  agcgatagg  ctctgcaaa  120
ggcgaaagt  ctaggtggg  gcggtgctg  atgcgcacc  gtgtcaaac  atcggactg  180
taaacatgt  gactccagt  aggagagtc  ggattccga  gacgattgc  ctctttgga  240
acgtaagcg  cagaaatgt  acagtcctc  tcccaagcc  gagcctttc  catttggac  300
gagcggtca  aaacaagct  tcaacggtg  gaagaaggt  aacaacatc  ggggtgctg  360
gctacagga  cagaaccaa  atgctgtgg  cactgagct  ggcatcttg  gaatggaag  420
caccatcga  agaagcagg  agtctgaga  ctataatta  ttgcttgct  agaaacttg  480
taagaagga  tctcaagag  atacaaaag  attagacaa  gatctggat  agtatatgc  540
tggcgacaa  aaacctggg  caaaggaag  ggagaatgg  caaggtcat  tcaaacgga  600
acggcctgt  cgagacaga  tgggtaaca  agtagaaat  aactacaaa  gccgctacg  660
catcacaga  gaggattct  ccgagaaag  ggctgatga  attgccttc  ggttacgga  720
ccgaagaag  acctgatag  ccgagtagt  acgatactt  ggaacaaaa  ggccattga  780
cttctgatg  agacggctg  ggttgagca  aatggtggc  ttttcataa  gaatggaag  840
cgaaggaga  cgccgggtg  ggttttcct  aatctcctg  agaacacgc  cagcatcag  900
gaagagcag  tcaaggata  tttctacat  gaaaatcaa  aagaatatg  aaataaaaa  960
gctgctaga  aaagaagaa  acaactatt  gggaagaaa  tgaaagaag  tattaaaag  1020
ctaaatttc  aggaagatg  tgacacatc  cgagaaacg  ttgcaagtg  cactaatga  1080
gccctggcc  ctcttgacg  agcccagga  ggacccggt  aaaccaagc  ggatgctga  1140
gacgccatc  acgtggacc  ccctcagga  ttggacatc  tttaagcac  ctttggaca  1200
tttgaagca  taaaccttt  ttttttaaa  aaggtgtta  caatttcta  tgaggttgc  1260
ttactgtgc  ccgacactg  ggcgggaga  ctgtgtctg  gctcccgtg  agtagtaat  1320
tatgtggta  tcgtgccgt  gccgcagtg  ggaaggtgg  tgcatctga  ggctgctgt  1380
cagcacggg  taatttctc  actctgcat  tgctgactg  tagcctacg  ggagctgtg  1440
cctctctgt  cagctcact  tttcatgcc  gtaagacat  ttggttttc  cattcatct  1500
tgtggtgaa  tatgctttg  ttttaa  1526



<210> 9943
<211> 235
<212> PRT
<213> Rattus norvegicus
<308> CAA48076
<400> 9943

Met Ala Leu Glu Ala Gly Asp Met Glu Glu Gly Gln Leu Ser Asp Ser 
  1               5                  10                  15
Asp Ser Asp Met Thr Val Val Pro Ser Asp Arg Pro Leu Gln Met Ala 
             20                  25                  30
Lys Val Leu Gly Gly Gly Gly Ala Ala Cys Ala Pro Val Ser Asn Tyr 
         35                  40                  45
Arg Thr Val Lys His Val Asp Ser Ser Glu Glu Ser Leu Asp Ser Asp 
     50                  55                  60
Asp Asp Cys Ser Leu Trp Lys Arg Lys Arg Gln Lys Cys His Ser Pro 
 65                  70                  75                  80
Pro Pro Lys Pro Glu Pro Phe Pro Phe Gly Gln Ser Gly Gln Lys Gln 
                 85                  90                  95
Ala Leu Asn Gly Gly Lys Lys Val Asn Asn Ile Trp Gly Ala Val Leu 
             100                105                110
Gln Glu Gln Asn Gln Asp Ala Val Ala Thr Glu Leu Gly Ile Leu Gly 
         115                120                125
Met Glu Gly Thr Ile Asp Arg Ser Arg Gln Ser Glu Thr Tyr Asn Tyr 
     130                135                140
Leu Leu Ala Lys Lys Leu Ala Lys Lys Glu Ser Gln Glu Tyr Thr Lys 
 145                150                155                160
Glu Leu Asp Lys Asp Leu Asp Glu Tyr Met His Gly Asp Lys Lys Pro 
                 165                170                175
Gly Ser Lys Glu Glu Glu Asn Gly Gln Gly His Leu Lys Arg Lys Arg 
             180                185                190
Pro Val Arg Asp Arg Leu Gly Asn Arg Val Glu Met Asn Tyr Lys Gly 
         195                200                205
Arg Tyr Asp Ile Thr Glu Glu Asp Ser Pro Glu Lys Val Ala Asp Glu 
     210                215                220
Ile Ala Phe Arg Leu Arg Asn Arg Arg Arg Thr 
 225                230                235



<210> 9944
<211> 2903
<212> DNA
<213> Homo sapiens
<308> XM_037004
<400> 9944

aagtgctct  ctgacccgc  gctgtgcag  gcagcgcac  gcgggaaga  ggcgttgga  60
gtcggcgat  tggaagatg  gcagctttc  gactcggat  ccgacatga  ggtcgcacc  120
agcgacagg  cgctgcaat  gccaaaagt  ctaggtggc  acagtgcta  gagggcctt  180
cagaacacg  caactgcat  tgcaccagt  tcacattat  gagctgttg  aagtgtgga  240
tcaagtgaa  aaagttttt  tgattcaga  gatgatagc  gtctttgga  acgcaaacg  300
cagaaatgt  ttaaccctc  tcccaaacc  gagcctttt  agtttggcc  gagcagtca  360
aaaccacct  ttgctggag  aaagaagat  aacaacata  ggggtgctg  gctgcagga  420
cagaatcaa  atgcagtgg  cactgaact  ggtatcttg  gaatggagg  cactattga  480
agaagcaga  aatccgaga  ctacaatta  ttgcttgcc  agaaactta  gaaggaatc  540
caagagcat  caaaagatc  agacaagga  ctagatgaa  atatgcatg  tggcaaaaa  600
atgggatca  aggaagagg  aaatgggca  ggtcatctc  aaaggaaac  acctgtcaa  660
gacaggcta  ggaacagac  agaaatgaa  tataaaggt  gatacgaga  cacagcgga  720
gattctcaa  agaaagtgg  tgatgaaat  tcattcagg  tacaggaac  aaagaaaga  780
ctgatagcc  gagtagtga  gattattgg  aacaaaaag  caattgaac  tctgatgga  840
accgctgaa  ttgaacaaa  tggtggtct  tttataatg  atggtagtc  aagaagaac  900
ccaggtgga  tttttctga  tctcttgaa  aacactcct  gtatcagcg  ggaacaaat  960
aaggacatt  tctacattg  aaaccaaaa  gaatatgaa  ataaaaaag  tgctaggaa  1020
aggagaaca  aagtgttgg  gaaaaagat  aaacaagct  ttaaaagtc  aaattttca  1080
gaagatgat  atacatcac  agaaacttt  gcaagtgac  cgaatgagg  cttggcctc  1140
cttgatgag  cacaggaag  acatgcaga  gccaagttg  aggcagagg  agccattga  1200
gttgatcat  ctcatgatt  ggacatctt  taagtacat  ttcaacagt  tgaggacta  1260
gcctttcta  aataacatt  taataaacc  tttttactg  gattgcaac  ttttgcact  1320
ataaacatg  gaatctgga  gaaagacaa  tgttttctt  tttaaaata  gtgtggaaa  1380
gaatgcaat  gatagaaca  ttaaagata  atctgacaa  atacttaag  gtatatagc  1440
caggattta  tttctcaat  tgttgcatg  gctaattat  agtattact  gttgataat  1500
agttttgtc  aggtcataa  ataccattt  taagtttgt  tgctttttc  ggtttatct  1560
tgcagtgaa  tatgctttg  tttaaaaca  tccgctaaa  tcataatgg  acatataaa  1620
tattaagct  ttagaaatg  attcaaatt  gttttttct  tgttctaag  actcaggca  1680
ttttaagga  aaaaactaa  attggccag  cacggtggc  cacgcctgt  atcccaaca  1740
tttaggaga  caaggcggg  agatcactt  aggtcagaa  tttgagacc  gccaggcca  1800
catggtgaa  cttcatctc  actaaaaat  caaaaacta  ccaggtgtg  ttctccatg  1860
ctataatcc  ggctactcg  gaggctgag  caggagaat  acctgaacc  ccaggctgg  1920
gtacagtgg  aggatctca  cttactgca  cttccatct  ccaggttca  gcgatcatg  1980
gcctaagcc  cctgagtag  tgggatcac  ggtgtgtac  accacgccc  gctgatttt  2040
gtattttta  taaagactt  cgccatgtt  tccaggctg  tctcgaact  ctggcctaa  2100
gatctgccc  cctctgcct  ccaaagtgc  gggatcaca  gcatgagcc  ccgaaccca  2160
ccttattct  cttaaattt  acgtgtttt  tgacttctt  attaacttg  tcatatact  2220
aatgtgatc  cctgtggat  accacatgc  ttaaaaaat  tttcaagct  ggcctagtg  2280
cgcacacct  caatcccaa  actttggga  gccaagaga  gaagattgc  tgagcccag  2340
agtttgaga  caatctagg  aatgtagtg  gaccctgtc  ctaatttaa  aaagaaaaa  2400
aaaaaaaca  tcccagtgg  agcctgcct  agactgtct  accttatgt  aaggaagtc  2460
ggtatttaa  atgttacat  tgccggcgc  gtggctcat  tgtgtaatc  cagcactct  2520
ggaggctga  acaggtaga  catttgagg  caggagttc  aaaccaacc  ggtctacat  2580
gtgaaaccc  atctcaact  aaaatacaa  aaatacaaa  aattagccg  gcgcggtgg  2640
tcacacctg  aatcccagc  ctttgggag  tggaggcgg  tggatcaca  ggtcaagag  2700
tcgagacca  cctggccaa  atggtgaaa  cctgtctct  ttaaaaata  aaaaattag  2760
tgggcgtgg  ggcgcatgc  tgtagtccc  actactagg  aggctgagg  aggagaatc  2820
cttgaaccc  ggaggtgga  gttgcagtg  gccgagatc  cgccactgc  ctccagcct  2880
gcgacagag  gagactccc  ctc  2903



<210> 9945
<211> 394
<212> PRT
<213> Homo sapiens
<308> XP_037004
<400> 9945

Met Ala Leu Glu Val Gly Asp Met Glu Asp Gly Gln Leu Ser Asp Ser 
  1               5                  10                  15
Asp Ser Asp Met Thr Val Ala Pro Ser Asp Arg Pro Leu Gln Leu Pro 
             20                  25                  30
Lys Val Leu Gly Gly Asp Ser Ala Met Arg Ala Phe Gln Asn Thr Ala 
         35                  40                  45
Thr Ala Cys Ala Pro Val Ser His Tyr Arg Ala Val Glu Ser Val Asp 
     50                  55                  60
Ser Ser Glu Glu Ser Phe Ser Asp Ser Asp Asp Asp Ser Cys Leu Trp 
 65                  70                  75                  80
Lys Arg Lys Arg Gln Lys Cys Phe Asn Pro Pro Pro Lys Pro Glu Pro 
                 85                  90                  95
Phe Gln Phe Gly Gln Ser Ser Gln Lys Pro Pro Val Ala Gly Gly Lys 
             100                105                110
Lys Ile Asn Asn Ile Trp Gly Ala Val Leu Gln Glu Gln Asn Gln Asp 
         115                120                125
Ala Val Ala Thr Glu Leu Gly Ile Leu Gly Met Glu Gly Thr Ile Asp 
     130                135                140
Arg Ser Arg Gln Ser Glu Thr Tyr Asn Tyr Leu Leu Ala Lys Lys Leu 
 145                150                155                160
Arg Lys Glu Ser Gln Glu His Thr Lys Asp Leu Asp Lys Glu Leu Asp 
                 165                170                175
Glu Tyr Met His Gly Gly Lys Lys Met Gly Ser Lys Glu Glu Glu Asn 
             180                185                190
Gly Gln Gly His Leu Lys Arg Lys Arg Pro Val Lys Asp Arg Leu Gly 
         195                200                205
Asn Arg Pro Glu Met Asn Tyr Lys Gly Arg Tyr Glu Ile Thr Ala Glu 
     210                215                220
Asp Ser Gln Glu Lys Val Ala Asp Glu Ile Ser Phe Arg Leu Gln Glu 
 225                230                235                240
Pro Lys Lys Asp Leu Ile Ala Arg Val Val Arg Ile Ile Gly Asn Lys 
                 245                250                255
Lys Ala Ile Glu Leu Leu Met Glu Thr Ala Glu Val Glu Gln Asn Gly 
             260                265                270
Gly Leu Phe Ile Met Asn Gly Ser Arg Arg Arg Thr Pro Gly Gly Val 
         275                280                285
Phe Leu Asn Leu Leu Lys Asn Thr Pro Ser Ile Ser Glu Glu Gln Ile 
     290                295                300
Lys Asp Ile Phe Tyr Ile Glu Asn Gln Lys Glu Tyr Glu Asn Lys Lys 
 305                310                315                320
Ala Ala Arg Lys Arg Arg Thr Gln Val Leu Gly Lys Lys Met Lys Gln 
                 325                330                335
Ala Ile Lys Ser Leu Asn Phe Gln Glu Asp Asp Asp Thr Ser Arg Glu 
             340                345                350
Thr Phe Ala Ser Asp Thr Asn Glu Ala Leu Ala Ser Leu Asp Glu Ser 
         355                360                365
Gln Glu Gly His Ala Glu Ala Lys Leu Glu Ala Glu Glu Ala Ile Glu 
     370                375                380
Val Asp His Ser His Asp Leu Asp Ile Phe 
 385                390



<210> 9946
<211> 1526
<212> DNA
<213> Rattus norvegicus
<308> X67877
<400> 9946

ctctcctga  cctgcgcgc  gcgggaaga  ggcgcttga  gctggcgac  tggaagagg  60
acagctttc  gactcggat  ccgacatga  ggtcgtccc  agcgatagg  ctctgcaaa  120
ggcgaaagt  ctaggtggg  gcggtgctg  atgcgcacc  gtgtcaaac  atcggactg  180
taaacatgt  gactccagt  aggagagtc  ggattccga  gacgattgc  ctctttgga  240
acgtaagcg  cagaaatgt  acagtcctc  tcccaagcc  gagcctttc  catttggac  300
gagcggtca  aaacaagct  tcaacggtg  gaagaaggt  aacaacatc  ggggtgctg  360
gctacagga  cagaaccaa  atgctgtgg  cactgagct  ggcatcttg  gaatggaag  420
caccatcga  agaagcagg  agtctgaga  ctataatta  ttgcttgct  agaaacttg  480
taagaagga  tctcaagag  atacaaaag  attagacaa  gatctggat  agtatatgc  540
tggcgacaa  aaacctggg  caaaggaag  ggagaatgg  caaggtcat  tcaaacgga  600
acggcctgt  cgagacaga  tgggtaaca  agtagaaat  aactacaaa  gccgctacg  660
catcacaga  gaggattct  ccgagaaag  ggctgatga  attgccttc  ggttacgga  720
ccgaagaag  acctgatag  ccgagtagt  acgatactt  ggaacaaaa  ggccattga  780
cttctgatg  agacggctg  ggttgagca  aatggtggc  ttttcataa  gaatggaag  840
cgaaggaga  cgccgggtg  ggttttcct  aatctcctg  agaacacgc  cagcatcag  900
gaagagcag  tcaaggata  tttctacat  gaaaatcaa  aagaatatg  aaataaaaa  960
gctgctaga  aaagaagaa  acaactatt  gggaagaaa  tgaaagaag  tattaaaag  1020
ctaaatttc  aggaagatg  tgacacatc  cgagaaacg  ttgcaagtg  cactaatga  1080
gccctggcc  ctcttgacg  agcccagga  ggacccggt  aaaccaagc  ggatgctga  1140
gacgccatc  acgtggacc  ccctcagga  ttggacatc  tttaagcac  ctttggaca  1200
tttgaagca  taaaccttt  ttttttaaa  aaggtgtta  caatttcta  tgaggttgc  1260
ttactgtgc  ccgacactg  ggcgggaga  ctgtgtctg  gctcccgtg  agtagtaat  1320
tatgtggta  tcgtgccgt  gccgcagtg  ggaaggtgg  tgcatctga  ggctgctgt  1380
cagcacggg  taatttctc  actctgcat  tgctgactg  tagcctacg  ggagctgtg  1440
cctctctgt  cagctcact  tttcatgcc  gtaagacat  ttggttttc  cattcatct  1500
tgtggtgaa  tatgctttg  ttttaa  1526



<210> 9947
<211> 235
<212> PRT
<213> Rattus norvegicus
<308> CAA48076
<400> 9947

Met Ala Leu Glu Ala Gly Asp Met Glu Glu Gly Gln Leu Ser Asp Ser 
  1               5                  10                  15
Asp Ser Asp Met Thr Val Val Pro Ser Asp Arg Pro Leu Gln Met Ala 
             20                  25                  30
Lys Val Leu Gly Gly Gly Gly Ala Ala Cys Ala Pro Val Ser Asn Tyr 
         35                  40                  45
Arg Thr Val Lys His Val Asp Ser Ser Glu Glu Ser Leu Asp Ser Asp 
     50                  55                  60
Asp Asp Cys Ser Leu Trp Lys Arg Lys Arg Gln Lys Cys His Ser Pro 
 65                  70                  75                  80
Pro Pro Lys Pro Glu Pro Phe Pro Phe Gly Gln Ser Gly Gln Lys Gln 
                 85                  90                  95
Ala Leu Asn Gly Gly Lys Lys Val Asn Asn Ile Trp Gly Ala Val Leu 
             100                105                110
Gln Glu Gln Asn Gln Asp Ala Val Ala Thr Glu Leu Gly Ile Leu Gly 
         115                120                125
Met Glu Gly Thr Ile Asp Arg Ser Arg Gln Ser Glu Thr Tyr Asn Tyr 
     130                135                140
Leu Leu Ala Lys Lys Leu Ala Lys Lys Glu Ser Gln Glu Tyr Thr Lys 
 145                150                155                160
Glu Leu Asp Lys Asp Leu Asp Glu Tyr Met His Gly Asp Lys Lys Pro 
                 165                170                175
Gly Ser Lys Glu Glu Glu Asn Gly Gln Gly His Leu Lys Arg Lys Arg 
             180                185                190
Pro Val Arg Asp Arg Leu Gly Asn Arg Val Glu Met Asn Tyr Lys Gly 
         195                200                205
Arg Tyr Asp Ile Thr Glu Glu Asp Ser Pro Glu Lys Val Ala Asp Glu 
     210                215                220
Ile Ala Phe Arg Leu Arg Asn Arg Arg Arg Thr 
 225                230                235



<210> 9948
<211> 2903
<212> DNA
<213> Homo sapiens
<308> XM_037004
<400> 9948

aagtgctct  ctgacccgc  gctgtgcag  gcagcgcac  gcgggaaga  ggcgttgga  60
gtcggcgat  tggaagatg  gcagctttc  gactcggat  ccgacatga  ggtcgcacc  120
agcgacagg  cgctgcaat  gccaaaagt  ctaggtggc  acagtgcta  gagggcctt  180
cagaacacg  caactgcat  tgcaccagt  tcacattat  gagctgttg  aagtgtgga  240
tcaagtgaa  aaagttttt  tgattcaga  gatgatagc  gtctttgga  acgcaaacg  300
cagaaatgt  ttaaccctc  tcccaaacc  gagcctttt  agtttggcc  gagcagtca  360
aaaccacct  ttgctggag  aaagaagat  aacaacata  ggggtgctg  gctgcagga  420
cagaatcaa  atgcagtgg  cactgaact  ggtatcttg  gaatggagg  cactattga  480
agaagcaga  aatccgaga  ctacaatta  ttgcttgcc  agaaactta  gaaggaatc  540
caagagcat  caaaagatc  agacaagga  ctagatgaa  atatgcatg  tggcaaaaa  600
atgggatca  aggaagagg  aaatgggca  ggtcatctc  aaaggaaac  acctgtcaa  660
gacaggcta  ggaacagac  agaaatgaa  tataaaggt  gatacgaga  cacagcgga  720
gattctcaa  agaaagtgg  tgatgaaat  tcattcagg  tacaggaac  aaagaaaga  780
ctgatagcc  gagtagtga  gattattgg  aacaaaaag  caattgaac  tctgatgga  840
accgctgaa  ttgaacaaa  tggtggtct  tttataatg  atggtagtc  aagaagaac  900
ccaggtgga  tttttctga  tctcttgaa  aacactcct  gtatcagcg  ggaacaaat  960
aaggacatt  tctacattg  aaaccaaaa  gaatatgaa  ataaaaaag  tgctaggaa  1020
aggagaaca  aagtgttgg  gaaaaagat  aaacaagct  ttaaaagtc  aaattttca  1080
gaagatgat  atacatcac  agaaacttt  gcaagtgac  cgaatgagg  cttggcctc  1140
cttgatgag  cacaggaag  acatgcaga  gccaagttg  aggcagagg  agccattga  1200
gttgatcat  ctcatgatt  ggacatctt  taagtacat  ttcaacagt  tgaggacta  1260
gcctttcta  aataacatt  taataaacc  tttttactg  gattgcaac  ttttgcact  1320
ataaacatg  gaatctgga  gaaagacaa  tgttttctt  tttaaaata  gtgtggaaa  1380
gaatgcaat  gatagaaca  ttaaagata  atctgacaa  atacttaag  gtatatagc  1440
caggattta  tttctcaat  tgttgcatg  gctaattat  agtattact  gttgataat  1500
agttttgtc  aggtcataa  ataccattt  taagtttgt  tgctttttc  ggtttatct  1560
tgcagtgaa  tatgctttg  tttaaaaca  tccgctaaa  tcataatgg  acatataaa  1620
tattaagct  ttagaaatg  attcaaatt  gttttttct  tgttctaag  actcaggca  1680
ttttaagga  aaaaactaa  attggccag  cacggtggc  cacgcctgt  atcccaaca  1740
tttaggaga  caaggcggg  agatcactt  aggtcagaa  tttgagacc  gccaggcca  1800
catggtgaa  cttcatctc  actaaaaat  caaaaacta  ccaggtgtg  ttctccatg  1860
ctataatcc  ggctactcg  gaggctgag  caggagaat  acctgaacc  ccaggctgg  1920
gtacagtgg  aggatctca  cttactgca  cttccatct  ccaggttca  gcgatcatg  1980
gcctaagcc  cctgagtag  tgggatcac  ggtgtgtac  accacgccc  gctgatttt  2040
gtattttta  taaagactt  cgccatgtt  tccaggctg  tctcgaact  ctggcctaa  2100
gatctgccc  cctctgcct  ccaaagtgc  gggatcaca  gcatgagcc  ccgaaccca  2160
ccttattct  cttaaattt  acgtgtttt  tgacttctt  attaacttg  tcatatact  2220
aatgtgatc  cctgtggat  accacatgc  ttaaaaaat  tttcaagct  ggcctagtg  2280
cgcacacct  caatcccaa  actttggga  gccaagaga  gaagattgc  tgagcccag  2340
agtttgaga  caatctagg  aatgtagtg  gaccctgtc  ctaatttaa  aaagaaaaa  2400
aaaaaaaca  tcccagtgg  agcctgcct  agactgtct  accttatgt  aaggaagtc  2460
ggtatttaa  atgttacat  tgccggcgc  gtggctcat  tgtgtaatc  cagcactct  2520
ggaggctga  acaggtaga  catttgagg  caggagttc  aaaccaacc  ggtctacat  2580
gtgaaaccc  atctcaact  aaaatacaa  aaatacaaa  aattagccg  gcgcggtgg  2640
tcacacctg  aatcccagc  ctttgggag  tggaggcgg  tggatcaca  ggtcaagag  2700
tcgagacca  cctggccaa  atggtgaaa  cctgtctct  ttaaaaata  aaaaattag  2760
tgggcgtgg  ggcgcatgc  tgtagtccc  actactagg  aggctgagg  aggagaatc  2820
cttgaaccc  ggaggtgga  gttgcagtg  gccgagatc  cgccactgc  ctccagcct  2880
gcgacagag  gagactccc  ctc  2903



<210> 9949
<211> 394
<212> PRT
<213> Homo sapiens
<308> XP_037004
<400> 9949

Met Ala Leu Glu Val Gly Asp Met Glu Asp Gly Gln Leu Ser Asp Ser 
  1               5                  10                  15
Asp Ser Asp Met Thr Val Ala Pro Ser Asp Arg Pro Leu Gln Leu Pro 
             20                  25                  30
Lys Val Leu Gly Gly Asp Ser Ala Met Arg Ala Phe Gln Asn Thr Ala 
         35                  40                  45
Thr Ala Cys Ala Pro Val Ser His Tyr Arg Ala Val Glu Ser Val Asp 
     50                  55                  60
Ser Ser Glu Glu Ser Phe Ser Asp Ser Asp Asp Asp Ser Cys Leu Trp 
 65                  70                  75                  80
Lys Arg Lys Arg Gln Lys Cys Phe Asn Pro Pro Pro Lys Pro Glu Pro 
                 85                  90                  95
Phe Gln Phe Gly Gln Ser Ser Gln Lys Pro Pro Val Ala Gly Gly Lys 
             100                105                110
Lys Ile Asn Asn Ile Trp Gly Ala Val Leu Gln Glu Gln Asn Gln Asp 
         115                120                125
Ala Val Ala Thr Glu Leu Gly Ile Leu Gly Met Glu Gly Thr Ile Asp 
     130                135                140
Arg Ser Arg Gln Ser Glu Thr Tyr Asn Tyr Leu Leu Ala Lys Lys Leu 
 145                150                155                160
Arg Lys Glu Ser Gln Glu His Thr Lys Asp Leu Asp Lys Glu Leu Asp 
                 165                170                175
Glu Tyr Met His Gly Gly Lys Lys Met Gly Ser Lys Glu Glu Glu Asn 
             180                185                190
Gly Gln Gly His Leu Lys Arg Lys Arg Pro Val Lys Asp Arg Leu Gly 
         195                200                205
Asn Arg Pro Glu Met Asn Tyr Lys Gly Arg Tyr Glu Ile Thr Ala Glu 
     210                215                220
Asp Ser Gln Glu Lys Val Ala Asp Glu Ile Ser Phe Arg Leu Gln Glu 
 225                230                235                240
Pro Lys Lys Asp Leu Ile Ala Arg Val Val Arg Ile Ile Gly Asn Lys 
                 245                250                255
Lys Ala Ile Glu Leu Leu Met Glu Thr Ala Glu Val Glu Gln Asn Gly 
             260                265                270
Gly Leu Phe Ile Met Asn Gly Ser Arg Arg Arg Thr Pro Gly Gly Val 
         275                280                285
Phe Leu Asn Leu Leu Lys Asn Thr Pro Ser Ile Ser Glu Glu Gln Ile 
     290                295                300
Lys Asp Ile Phe Tyr Ile Glu Asn Gln Lys Glu Tyr Glu Asn Lys Lys 
 305                310                315                320
Ala Ala Arg Lys Arg Arg Thr Gln Val Leu Gly Lys Lys Met Lys Gln 
                 325                330                335
Ala Ile Lys Ser Leu Asn Phe Gln Glu Asp Asp Asp Thr Ser Arg Glu 
             340                345                350
Thr Phe Ala Ser Asp Thr Asn Glu Ala Leu Ala Ser Leu Asp Glu Ser 
         355                360                365
Gln Glu Gly His Ala Glu Ala Lys Leu Glu Ala Glu Glu Ala Ile Glu 
     370                375                380
Val Asp His Ser His Asp Leu Asp Ile Phe 
 385                390



<210> 9950
<211> 3227
<212> DNA
<213> Rattus norvegicus
<308> X68101
<400> 9950

taagctgtc  cgtggacat  gtccactca  gaagaaagt  tttgatgtc  acctgtgtt  60
cctccaaaa  catcagtca  aaatggctt  aaaaaatgt  ttcactgcc  taaggtcat  120
aatttataa  ttcccctca  cgttctacg  ggggcgggc  gacatgtgc  catctctgt  180
ctatgaggt  ctcaagtgc  gtaactcca  gctcagctc  atccgcacc  aggcctccc  240
gctgctcta  ttcctgatg  ggaacaact  cgactacac  gggaagaag  cttttgtcc  300
gacacactt  caggtcatc  tctctctca  ccagctgat  gcagacgtg  ttggcattg  360
aggaaccag  ttccagcag  ccttgtcta  catcaacaa  tgtgccaat  gcgaccggc  420
cattaagca  accagcttc  cctctgatg  gaaggattt  accaagagg  tccgcacag  480
cctgatggc  acagcccag  tgaaggaac  tgagaacga  ccagagatg  tggtggacc  540
gcagtacag  ctggccaag  cctacgcca  cacccctga  ctcaggaag  catggctgg  600
cagcatggc  aggatccat  ttaaaaatg  ggatctctc  gaggcagca  tgtgctatg  660
ccacgtgac  gctttggta  cggaatatc  cacacggaa  gaagctgac  tagcactcc  720
gcgggaacc  cctgtcttc  cctacagcc  tacctcctg  cagaggaag  gccggggag  780
catgttcag  caggggtgc  cagccttca  ggtcatcac  ccaaacatt  atgaagagg  840
ttccatgat  gaagatgtc  gcatgcagg  tgtccattt  aatgaggat  tgctgatgg  900
gctgctgga  cagtgcgca  atggacttt  gaaggcaga  cggctacga  ctggattgc  960
gacatctat  aactcatca  ccccatcta  gaaaagcgg  gggacttta  agactaccc  1020
cctgtatga  accctgcac  gcccataca  caaagtgac  gaggtcatc  ctcgggccg  1080
aggctcctg  gacctactt  cgggtggcc  cttcggaca  ggattcttc  aagatgaag  1140
cgggaagga  tacatctac  aagagccca  actcacgcc  ctgtcagag  tttctcaga  1200
actccttaa  ctttactcg  ataaattcg  ttctgaaaa  gtcaaaatg  tacaggatt  1260
tggcaaggt  aacccgaag  atctggatt  caagtttgc  tacatccag  tgacccatg  1320
gaccccgtt  tttgatgaa  aggagttac  ggagaggaa  acagagttt  aacgatgtc  1380
caacatccg  cgcttcatg  tcgagatgc  cttcaccca  actgggaag  ggcagggtg  1440
cgtggagga  cagtgtaag  gacggacca  cctgacagc  atacactgc  tcccctatg  1500
aaagaagcg  atccctgtc  tgtaccagc  ccacactga  ctgaacccc  ttgaggtgg  1560
catcgatga  atgagcaag  aagtggccg  gctccacca  ctgtgttcc  cagctgaag  1620
ggacatgat  aaactgcag  tcaaactgc  gggcagtgt  agcgtccag  tcaatgctg  1680
cccgctagc  tacgcccga  ccttcctcg  tgacaccaa  acaaagaga  accctgaca  1740
taaggtgaa  ctgctgaag  aagttttca  gcaattcgt  gaagcttgt  gccaagcct  1800
ggcagtgaa  gaacgtctg  ttaaagagg  ccagctgga  taccaggaa  agatgaaag  1860
caactacag  gagatccgg  aggagctct  cgacatcat  gtgccgaga  tttgccctg  1920
agaggacaa  cgtgctacc  aattccctg  acatcttca  cgccatcag  gggacacca  1980
caagcacag  ggttcaagg  ttgaccagt  catcctcag  tgtgtgact  tacctcatg  2040
accacacgt  gggacatgc  ttgtcatgt  caaactcag  acgactttc  gagctaatc  2100
ctggttttg  caagcacag  aagaagcca  ggggaatgg  agagagaaa  agccctgga  2160
tgtgatatt  aatagcaga  tttatagga  ttgggggaa  gtgcacata  ttttttaaa  2220
ctcactggc  atgtttagt  ttcctcatg  cttaacagg  gtatgtgga  actcttggg  2280
tgcagttca  ttttattct  cttacagta  agtattaaa  taaatggtc  aaaggaaaa  2340
agggaaagt  tgctgggac  cctgtagca  gtgtgctgg  acacctgta  cagctgtgc  2400
gggacacct  taccagctg  gctgggaca  ctgtagcag  tgcagcagc  ctgaacctg  2460
gaatgggga  taagctgga  aaatcttga  aatattttt  tccctgtgg  acattcagg  2520
tgagtacaa  aactatttt  gtgtctagt  ttgaagact  aaaggaatt  actattgag  2580
ttttttact  gtgaatgcg  agacttaga  cctttatat  catgccttg  gttgacaac  2640
tgagcactt  cgaagctga  tgtgatgtg  gcctaagcc  agtcagcag  atagaacca  2700
aggcctgca  tagcgaaca  acctatgct  aaacctaaa  ccccatgta  atatgttct  2760
ttaatacgg  ctcctcgct  agtccacgt  cttactaca  ttctacact  ttaatacat  2820
agtgtccgt  ttaagttta  tattcgtga  ccatttgtg  tgttctcgg  atatgcaaa  2880
acattggac  tcactgttt  ttcttgtac  taagaagtg  aatatggag  tgtatacag  2940
ctttgctat  ttaggttta  aaactgttt  taaaaagaa  ttcatcctt  tgccaaaat  3000
gtggagtat  tgattggta  accctaaac  ctgtggtga  tggagggat  atttaaagt  3060
ttcaccatg  tatattttc  tttaagact  taatttagt  attttatat  tgggaaaat  3120
aaggttttt  atttaactg  aatcactgc  ctgctgtaa  tacatatca  gtaccccaa  3180
tgtattaaa  ataacactg  tgattttct  gtaaaaaac  aaaaaaa  3227



<210> 9951
<211> 738
<212> PRT
<213> Rattus norvegicus
<308> CAA48220
<400> 9951

Lys Leu Ser Arg Gly His Ser Pro Leu Met Lys Lys Val Phe Asp Val 
  1               5                  10                  15
Tyr Leu Cys Phe Leu Gln Lys His Gln Ser Glu Met Ala Leu Lys Asn 
             20                  25                  30
Val Phe Thr Ala Leu Arg Ser Leu Ile Tyr Lys Phe Pro Ser Thr Phe 
         35                  40                  45
Tyr Glu Gly Arg Ala Asp Met Cys Ala Ser Leu Cys Tyr Glu Val Leu 
     50                  55                  60
Lys Cys Cys Asn Ser Lys Leu Ser Ser Ile Arg Thr Glu Ala Ser Gln 
 65                  70                  75                  80
Leu Leu Tyr Phe Leu Met Arg Asn Asn Phe Asp Tyr Thr Gly Lys Lys 
                 85                  90                  95
Ser Phe Val Arg Thr His Leu Gln Val Ile Ile Ser Leu Ser Gln Leu 
             100                105                110
Ile Ala Asp Val Val Gly Ile Gly Gly Thr Arg Phe Gln Gln Ser Leu 
         115                120                125
Ser Ile Ile Asn Asn Cys Ala Asn Ser Asp Arg Leu Ile Lys His Thr 
     130                135                140
Ser Phe Ser Ser Asp Val Lys Asp Leu Thr Lys Arg Ile Arg Thr Val 
 145                150                155                160
Leu Met Ala Thr Ala Gln Met Lys Glu His Glu Asn Asp Pro Glu Met 
                 165                170                175
Leu Val Asp Leu Gln Tyr Ser Leu Ala Lys Ser Tyr Ala Ser Thr Pro 
             180                185                190
Glu Leu Arg Lys Thr Trp Leu Asp Ser Met Ala Arg Ile His Val Lys 
         195                200                205
Asn Gly Asp Leu Ser Glu Ala Ala Met Cys Tyr Val His Val Thr Ala 
     210                215                220
Leu Val Ala Glu Tyr Leu Thr Arg Lys Glu Ala Asp Leu Ala Leu Gln 
 225                230                235                240
Arg Glu Pro Pro Val Phe Pro Tyr Ser His Thr Ser Cys Gln Arg Lys 
                 245                250                255
Ser Arg Gly Gly Met Phe Arg Gln Gly Cys Thr Ala Phe Arg Val Ile 
             260                265                270
Thr Pro Asn Ile Asp Glu Glu Ala Ser Met Met Glu Asp Val Gly Met 
         275                280                285
Gln Asp Val His Phe Asn Glu Asp Val Leu Met Glu Leu Leu Glu Gln 
     290                295                300
Cys Ala Asp Gly Leu Trp Lys Ala Glu Arg Leu Arg Ala Gly Leu Leu 
 305                310                315                320
Thr Ser Ile Asn Ser Ser Ser Pro Ser Met Lys Ser Gly Gly Thr Leu 
                 325                330                335
Glu Thr Thr His Leu Tyr Asp Thr Leu His Arg Pro Tyr Ser Lys Val 
             340                345                350
Thr Glu Val Ile Thr Arg Ala Ala Gly Ser Trp Asp Leu Leu Pro Gly 
         355                360                365
Gly Leu Phe Gly Gln Gly Phe Phe Glu Asp Glu Asp Gly Lys Glu Tyr 
     370                375                380
Ile Tyr Lys Glu Pro Lys Leu Thr Pro Leu Ser Glu Ile Ser Gln Arg 
 385                390                395                400
Leu Leu Lys Leu Tyr Ser Asp Lys Phe Gly Ser Glu Asn Val Lys Met 
                 405                410                415
Ile Gln Asp Ser Gly Lys Val Asn Pro Lys Asp Leu Asp Ser Lys Phe 
             420                425                430
Ala Tyr Ile Gln Val Thr His Val Thr Pro Phe Phe Asp Glu Lys Glu 
         435                440                445
Leu Gln Glu Arg Lys Thr Glu Phe Glu Arg Cys His Asn Ile Arg Arg 
     450                455                460
Phe Met Phe Glu Met Pro Phe Thr Gln Thr Gly Lys Arg Gln Gly Gly 
 465                470                475                480
Val Glu Glu Gln Cys Lys Arg Arg Thr Ile Leu Thr Ala Ile His Cys 
                 485                490                495
Phe Pro Tyr Val Lys Lys Arg Ile Pro Val Met Tyr Gln His His Thr 
             500                505                510
Asp Leu Asn Pro Ile Glu Val Ala Ile Asp Glu Met Ser Lys Lys Val 
         515                520                525
Ala Glu Leu His Gln Leu Cys Ser Ser Ala Glu Val Asp Met Ile Lys 
     530                535                540
Leu Gln Leu Lys Leu Gln Gly Ser Val Ser Val Gln Val Asn Ala Gly 
 545                550                555                560
Pro Leu Ala Tyr Ala Arg Ala Phe Leu Asp Asp Thr Asn Thr Lys Arg 
                 565                570                575
Tyr Pro Asp Asn Lys Val Lys Leu Leu Lys Glu Val Phe Arg Gln Phe 
             580                585                590
Val Glu Ala Cys Gly Gln Ala Leu Ala Val Asn Glu Arg Leu Ile Lys 
         595                600                605
Glu Asp Gln Leu Glu Tyr Gln Glu Glu Met Lys Ala Asn Tyr Arg Glu 
     610                615                620
Ile Arg Lys Glu Leu Ser Asp Ile Ile Val Pro Arg Ile Cys Pro Gly 
 625                630                635                640
Glu Asp Lys Arg Ala Thr Lys Phe Pro Ala His Leu Gln Arg His Gln 
                 645                650                655
Arg Asp Thr Asn Lys His Ser Gly Ser Arg Val Asp Gln Phe Ile Leu 
             660                665                670
Ser Cys Val Thr Leu Pro His Glu Pro His Val Gly Thr Cys Phe Val 
         675                680                685
Met Cys Lys Leu Arg Thr Thr Phe Arg Ala Asn His Trp Phe Cys Gln 
     690                695                700
Ala Gln Glu Glu Ala Met Gly Asn Gly Arg Glu Lys Glu Pro Trp Thr 
 705                710                715                720
Val Ile Phe Asn Ser Arg Phe Tyr Arg Ser Trp Gly Lys Val His Ile 
                 725                730                735
Phe Phe 
             740



<210> 9952
<211> 7545
<212> DNA
<213> Homo sapiens
<308> AB028981
<400> 9952

ctggcatgc  tgtgccttg  acggccagg  actcgcagc  gttccagtt  cagactttc  60
gacttgcgt  ttcagccga  aatgcaggc  gataaatgc  ggacaagta  tagaagtgt  120
aaaaaggaa  tggtgattg  gtcccccct  caatacaag  atgcagctc  gggcgaagt  180
gaagcagag  gcccgggcc  tgtgccggc  aagccaaag  taattgagc  actcgacta  240
gaaaatgtc  tcgtccaga  gaagactca  atcctgaac  actgtttac  ggagatgct  300
ctcttccct  acgatgact  tcagacggc  atcctgaga  gacagggtc  atacatatg  360
tcaacagtg  ctgcgaagg  ggaagagga  gcacagagc  tgtttgtta  agagtgcat  420
aaaacctat  actctgact  gcatcttgt  aactataaa  atgaagatt  ctcaggaga  480
tttcgacag  ttccgaaca  agtggtcaa  ttggataaa  ttccagttc  tgtctatga  540
gttgacgag  aggtcgaca  agatgagga  gctgcctcc  ttggttccc  gaagggtgg  600
atcaccaag  atggctggc  gtacaaagg  aacatgaac  gtgccatca  cgtgaccat  660
aggtcattt  agagacgat  tttccacct  attcaactt  gcgatggat  ctataattt  720
aatttttat  aagatgaaa  gatctccaa  gaaccaaaa  gatcaatat  tctggattc  780
tgtatgggt  tcgttcaga  caacaaagt  aggcgtttt  cttttgagc  caagatgca  840
gacaaaagt  gttatctct  ggcagcaga  agtgaagtg  aaatggaag  atggatcac  900
attctaaat  agatcctcc  gctcaactt  gaagctgca  tgcaagaaa  gcgaaatgg  960
gactctcac  aagatgatg  acaaagcaa  ttggaaggt  ctggttccg  tttagatag  1020
tacctgccg  aacttgcca  gagtgcaag  gaagcagaa  tcaaactga  aagtgaaag  1080
agagtcaaa  ttttttatt  ggacccaga  gcccagaag  ttgacttct  atcagctga  1140
ccagaagtg  agtcatttg  agagaagtt  ggaaaaagg  tccttgtca  gtgcaatga  1200
ttatctttc  atttgcaat  ctgtgttgc  gaaaatgaa  aaggaccca  tacaaatgt  1260
gaacctttc  ttgttactc  atccctgtt  gacataaaa  acaaccgga  gatttctgc  1320
gatttccac  tagacctga  ccatttctc  gtgaggcaa  tgctcgcca  cacgtcccc  1380
gcgctgatg  atggcagtg  gcagagccc  tctgtcctc  agggcatcc  tcatgaagc  1440
gccatgcag  atccgaagc  gggaatatt  tcagtcact  gtcctcatc  agatatatt  1500
cttgtggcc  gaattgaaa  agtccttca  gggagcatc  cacattgcg  tgagccata  1560
atgaaaagt  cagactctt  taaggtggc  cagaaggtg  tgaagaatg  caagcaggc  1620
tgccaaaga  taggacagt  tagaatgcc  tttgcttgg  cagcaagga  attgtttaa  1680
gatgcatct  gaaatcttg  caaaaatgc  agattttct  ccatctaca  gcaagacag  1740
aataagcta  ccaatgatg  catgctcaa  ttacttgca  actttcgga  acctgagaa  1800
atggctaag  tcccagtga  tttaggcaa  ctagacatt  caattgata  tgtttcctc  1860
gacttccct  attatgtta  ttcatcata  attcccaca  aacaatttg  aacctgcag  1920
aaaactccc  tcacgtttg  agtggagga  tttgtgccc  gcataccaa  acacactca  1980
ccttacacc  tctacacca  tcaccttta  gtttatcct  agtacttga  atacgacag  2040
cagaagtct  ttgccaagg  tagaaatat  gcgatttgc  ttgaattca  agattcaga  2100
gaggaagac  ctcagcccc  taagtgcat  tatggcaga  ctggtgggc  agttttcac  2160
agaagcgcc  ttgctgcag  tttacacca  caccaaaac  cagaatttt  tgatgagat  2220
aaaatagag  tgcccactc  gctgcatga  aagcaccac  tgttgctca  attcttcca  2280
gtcagctgt  acaactcaa  taaaggaag  acgaagaag  gggatgtcg  tgaaaccca  2340
gttggctac  cctggcttc  cctcctgaa  gacggaagg  tggtgacaa  cgagcagca  2400
atcccggtc  cggcgaacc  tccttcggg  tatcttggc  accaggagc  tgggatggg  2460
aggcattat  gtccggaaa  taaatgggt  gatggaggc  agccactgc  gaaaatttc  2520
actcatctg  tttctacag  gtatactca  gatcagcat  tacataatt  tttccagta  2580
tgtcagaaa  ccgaatctg  agcccaagc  ttaggaaac  aacttgtaa  gtaccttaa  2640
agtctgcat  cgatggaag  ccacgtgat  atcgccttc  tgcccacta  cctaaacca  2700
ctgttccga  tcctcacca  agccacaca  gaagaagtc  cggttaacg  gactcgggt  2760
attattcat  tggttgccc  gtgccatga  gaaggattg  agagccact  gaggtcata  2820
gttaagtac  cgtataagg  tgagccata  gttgcctct  aatacaaga  agtgcatga  2880
gaactgacc  aatccatga  cacgattct  aagccttct  ccgatttcc  caccagcaa  2940
aaactactg  agtactcat  gtttttctt  gatgtactg  tcaaatcta  ggctcagca  3000
ttgatagag  actccaaag  taagttgct  cgaaaccag  gatttcctg  atcctatca  3060
catgcagtg  aaaccgttg  aaatatgct  atgccacac  tcactcaga  gtttcgaga  3120
aatccagag  catctaaga  cgcgaatca  agccttgct  tcttcatca  gagatgttt  3180
accttcatg  acaggggct  tgtcttcaa  cagatcaac  actacatta  ctgttttgc  3240
cctggagac  caaagaccc  ctttgaata  aagtttgaa  ttctccgtg  agtgtgcaa  3300
catgaacat  atattccgt  gaacttacc  atgccattt  gaaaaggca  gattcaaag  3360
taccaagac  tccagcttg  ctactcatt  acagatgag  tctgcagaa  ccacttctt  3420
gtgggactg  tactgaggg  ggtggggac  gccctccag  agttccggg  ggtccgtct  3480
atcgccatc  gtgtgctca  gaacctgct  ataaagcat  cttttgatg  cagatatgc  3540
tcaaggagc  atcaggcaa  gatagccac  ctctacctg  ctctgtttg  tctgctgat  3600
gaaaacgtc  agcggatca  tgtgaggga  gtgtcaccc  tccctgtga  cgcgggcat  3660
actgtgaag  atgaatccc  ggctctacc  gctgtgaat  cgctggtga  gccgcagaa  3720
ggaagcacc  tggacaaca  cctgcacaa  gacctgctg  gcgccatct  cggcattgc  3780
tctccatat  caacctcaa  tccaaacat  aacagtgtg  gaaatgctg  ttcgagagg  3840
tctctcata  gcacagatt  gggtaacag  cttccagaa  ggaatagtg  gaagagcaa  3900
tccctggat  agcaccaac  aagtagcac  ttgggaaat  ccgtggttc  ctgtgataa  3960
cttgaccag  ctgagatta  gagcctact  atgtgtttc  tctacatct  aaagagcat  4020
tctgatgat  ctttgttta  atattggaa  aaggcttca  catctgaac  tatggattt  4080
tttacaata  ctgaagtct  cctgcacca  ttccagtac  tggggaagc  atacatagc  4140
agaacagga  tgatgcatg  cagattgca  cagctgggc  gcctggata  ctctctcac  4200
tttaaccac  gctatggcc  ctcggacgc  gatgttctg  accagtcat  acttgaagc  4260
aacattgct  ctgaggttt  cctgacagc  ctggacacg  tttctctat  tacattggc  4320
tttaagaac  agctcctgg  cgaccatgg  cataatcct  tcatgaaaa  agtttttga  4380
gtctacctg  gttttcttc  aaaacatca  tctgaaacg  ctttaaaaa  tgtcttcac  4440
gccttaagg  ccttaattt  taagtttcc  tcaacattc  atgaaggga  agcggacat  4500
tgtgcggct  tgtgttacg  gattctcaa  tgctgtaac  ccaagctga  ctccatcag  4560
acggaggcc  cccagctgc  ctacttcct  atgaggaac  actttgatt  cactggaaa  4620
aagtccttt  tccggacac  tttgcaagt  atcatatct  tcagccagc  gatagcaga  4680
gttgttggc  ttgggggaa  cagattcca  cagtccctg  ccatcatca  caactgtgc  4740
aacagtgac  ggcttatta  gcacaccag  ttctcctct  atgtgaagg  cttaaccaa  4800
aggatacgc  cggtgctaa  ggccaccgc  cagatgaag  agcatgaga  cgacccaga  4860
atgctggtg  acctccagt  cagcctggc  aaatcctat  ccagcacgc  cgagctcag  4920
aagacgtgg  tcgacagca  ggccaggat  catgtcaaa  atggcgatc  ctcagaggc  4980
gcaatgtgc  atgtccacg  aacagccct  gtggcagaa  atctcacac  gaaagaagc  5040
gtccagtgg  agccgcccc  tctccccca  agccatagc  cctgcctga  gaggagccg  5100
ggaggcgtg  ttagacaag  atgcaccgc  ttcagggtc  ttaccccaa  catcgacga  5160
gaggcctcc  tgatggaag  cgtggggat  caggatgtc  atttcaacg  ggatgtgct  5220
atggagctc  ttgagcagt  cgcagatgg  ctctggaaa  ccgagcgct  cgagctcat  5280
gccgacatc  acaaactta  catccccat  tatgagaag  ggagggatt  tgagaggct  5340
gcccatctg  atgacacgc  gcaccgggc  tacagcaaa  tgaccgagg  catgcactc  5400
ggccgcagg  ttctgggga  ctacttccg  gtagccttc  tcgggcagg  agcgcaata  5460
cagtttaca  acagtgaaa  agatgtgga  ggattcttt  aagatgaag  tggaaagga  5520
tatatttac  aggaaccca  actcacacc  ctgtcggaa  tttctcaga  actccttaa  5580
ctgtactcg  ataaatttg  ttctgaaaa  gtcaaaatg  tacaggatt  tggcaaggt  5640
aaccctaag  atctggatt  taagtatgc  tacatccag  tgactcacg  catcccctt  5700
tttgacgaa  aagagttgc  agaaaggaa  acagagttt  agagatccc  caacatccg  5760
cgcttcatg  ttgagatgc  atttacgca  accgggaag  ggcagggcg  ggtggaaga  5820
cagtgcaaa  ggcgcacca  cctgacagc  atacactgc  tcccttatg  gaagaagcg  5880
atccctgtc  tgtaccagc  ccacactga  ctgaacccc  tcgaggtgg  cattgacga  5940
atgagtaag  aggtggcgg  gctccggca  ctgtgctcc  cggccgagg  ggacatgat  6000
aaactgcag  tcaaactcc  gggcagcgt  agtgttcag  tcaatgctg  cccactagc  6060
tatgcgcga  ctttcttag  tgatacaaa  acaaagcga  atcctgaca  taaagtgaa  6120
ctgcttaag  aagttttca  gcaatttgt  gaagcttgc  gtcaagcct  agcggtaaa  6180
gaacgtctg  ttaaagaag  ccagctcga  tatcaggaa  aaatgaaag  caactacag  6240
gaaatggcg  aggagcttt  tgaaatcat  catgagcag  tgggatgat  tgccccctg  6300
aggagaaga  gagcgtctt  ccgaattcc  ttcacatct  caacgccat  agtgggact  6360
caacaagca  aatggttca  gggatgacc  gctcgtctt  ggtcgtgtg  ttacatctc  6420
tggcccgtg  gtggggact  gctttgtca  ttgcaaact  aggatgctt  ccaaagcca  6480
tcactgggg  gaccgagca  agggaggac  aggggaagg  gagagaaag  aaataaaga  6540
caacgttat  tcttaacag  ctttctata  gagttgtaa  aaggtgcac  tattttttt  6600
aatctcact  gcaatattc  aagttttca  tgtgtctta  caaaggtgt  gtagacact  6660
ttgagctgg  cttagattt  attcttcct  gcagagtag  gttagaata  atggcctac  6720
gaaaaaaaa  gttctggga  ctacatggc  gggagggct  cactgacat  gatgcctgg  6780
ggacctttt  cctcgaggc  gagctggaa  atcttgaaa  tattttttt  ttcctgtgg  6840
acattcagg  tgaatacaa  aactatttt  gtgactagt  tttgatgac  taagggaac  6900
gaccattgt  atttttgta  cagtgaacc  ggagattta  tgcttttat  ttcatttcc  6960
tgcatttaa  aaaatatga  agcttaagg  attatgtga  cttaaaact  gtcaagcag  7020
ttagaacca  aggcctata  taataaccg  aactatgct  aaaagtaca  agtagtaca  7080
tatattgtt  tgtacatat  attgttaat  cagtcctgg  attctgtac  tatatgtat  7140
acatttcta  atttttaat  ctcacatgg  cttatgcat  aagtttaat  gtgataaat  7200
tgtgctgtt  cagtatatg  aatacactt  aatgtttta  tcttgtaca  aaaaatgtg  7260
aatatggag  tgtatacag  ctttactat  ttaggttta  aaacagttt  aagaatttc  7320
tccttttgc  aaaatggtg  agtatgtaa  tggtaaatc  taaatcctg  ggtgaatgg  7380
ggtgtactt  aaagctgtc  ccatgttat  ttttctttt  agacattaa  ttagtaatt  7440
tatatttgg  aaaataaag  tttttaatt  tatttaact  gaatcactg  cctgctgta  7500
ttaaacatt  tgtaccaca  ctgtattaa  aagacattg  tgacc  7545



<210> 9953
<211> 3350
<212> DNA
<213> Rattus norvegicus
<308> X68394
<400> 9953

cgggtgggg  cggaagtgc  gctcccggg  gggggctgt  catggcggt  tcggggtct  60
caacagctt  tcaggttga  atccaaaag  ctcccgagg  gggtctgcg  agtttgaga  120
ttttgcagg  gtgaaatga  tgagtacaa  ctggtggtg  ttggagcag  tggcgttgg  180
aaaagtgct  tgacaatcc  gctaatcca  aaccacttt  tggatgaat  tgatcccac  240
atagaggat  cttaccgaa  acaagtggt  attgacggt  agacctgtc  actggacat  300
ctggacaca  ctggacaag  ggagtacag  gccatgaga  accaataca  gaggacagg  360
gaagggttc  tctgtgtgt  tgccatcaa  aatagcaaa  cctttgcag  tattaacct  420
tacagggag  aaattaagc  ggtgaaaga  tctgatgat  tacccatgg  gctggtagg  480
aacaagtgt  acttgccaa  aaggacagt  gacacaaag  aagcccacg  gctggccaa  540
agttatgga  ttccattca  tgaaacctc  gccaagacc  gacagggtg  ggaggatgc  600
ttttacacg  ttgtaaggg  gatacgcca  taccggatg  agaagctca  cagcagtga  660
gatggcact  aaggctgta  ggggctgcc  tgtgtggtg  tgtagtaag  ccctttaaa  720
gttctgtca  cagaaacga  ccactttca  gcctcactg  tgccctggt  ctgacatcc  780
tggaggaga  gtgtttctg  tgctctctg  atctcagag  agctcctgc  tcctgcttc  840
ccaacttag  tactgagca  agccatcta  cctgagacc  cttcagaat  actacctcc  900
cactcggct  tccgaacca  agaaatgaa  ctgtttctc  ccagtagtt  tctgccctg  960
gtttcccct  gaaacaaac  cacctgcca  ctggctttg  cctccgaaa  gcagtttac  1020
ttgatgcac  agaaccaaa  tatagacaa  caattctgt  gtcaacagt  tcttaagct  1080
taaggtaac  attgctggt  atttccccc  ttgccccca  ctgttgaac  tggccttgt  1140
agttttggg  gaaatgtaa  aattaatcc  cttccccga  aatagaatt  gtgttgctg  1200
ttgcctgat  tgcaatgtg  tcagctata  tctataagc  ggcgtctgc  ctgtattca  1260
aaatgcaaa  atgagtact  acgtaagtg  atccctagt  ttctcagct  catgcaatt  1320
aatccaacg  tcacaacaa  gtgccttgt  ctaacagtg  tctgtaggc  tccgttata  1380
ttcgtattg  aatagatgt  tcaagaacc  ttgtatagg  aagtgacta  gagccatct  1440
ccttggagg  aaaggtgaa  ctacctgat  gcagatgct  gtatatgta  acatatgta  1500
acaaagaca  tttccctgt  tgcggttct  ccaggagaa  gagggaact  aaacgatta  1560
gactaattt  atttaattc  agctaatct  ttttttttt  tttggaggg  gggagtagg  1620
taccaccta  aaatatttg  aatttcttc  agcttactg  taatctaat  gtcaatgag  1680
ttccattat  ataaattgg  tcataccag  aagccctcc  tttatagtt  gtcagatac  1740
gtaaaaatt  gcatgttat  actttatac  tgtgattaa  gattcttca  accttaaat  1800
tagttattg  aggcaggtt  tatctttgc  gcatagttt  ttcatggaa  aaaaaaaat  1860
tatatatat  tggagagag  ggccctcag  tcccatctc  ccatccctc  ctttcagcc  1920
agatcagtt  aagcatcct  taggagctt  aataattat  tcagttgaa  aaaccatgg  1980
gctaatgga  caggtcatg  tttcaaaac  tgaacaagc  agttagatc  cagagaaaa  2040
agttcatcc  tatttgcct  cctgcctat  actcctgct  gtagacttt  gcctgatgc  2100
tgctgttcg  gctataagg  taaaagtta  tgtggttct  caccaggac  gggaatgcc  2160
ggtgagctg  tgggtaagc  tagacacct  tacattttc  gacccgtat  tttagcccc  2220
tggaaactg  agccagagt  cacacctcc  tctcttccc  cattagata  atgttctta  2280
tctatatag  tttttaaaa  tatttaaaa  atgtctata  gttaggcta  caactaaca  2340
aagctgatg  gtttgttca  ataaagagg  atcctttac  acttgagaa  agaatgtaa  2400
atgccatta  ttgttgtca  gtagaagtt  gatatttgt  gtaatgccc  gataattca  2460
tggtgagtt  gttagtcat  gtgatactt  aaatataac  catctcagt  atttcaatg  2520
aaacataaa  tgggatgcc  tgattgaaa  aagcaaacc  aattccaaa  tgaccattt  2580
ctcttctga  cttacgaca  ctaaaaatc  gagatcctt  ggattcatt  gtttataac  2640
ggaacttgc  atgtaatct  ggctggcct  aaactcaca  tgctcttcc  gcatcagtc  2700
ccaaaatga  gggattaca  gcacatgcc  ccacacaca  ctgatctgg  ttctaatga  2760
tttttattg  taagcaaat  cccatcacc  tgaaactaa  cagaagagg  aagaaacat  2820
tgttgtgct  ctcagtgct  atgctggga  ctttcacca  gggtttgca  tcttaagta  2880
actgctgcc  ttttacaac  taggctcag  catcctcct  aagctgctt  agaccaaca  2940
ttggtcttg  tctttttta  tgtgtctgt  tgactggtg  tggatctct  aaaagttta  3000
taaactcca  ttagggaga  agttactcc  cttggccct  ttgaccata  ccatgtgtg  3060
gtgtgtgtg  gtgtgtgtg  gtgtgtgtg  gtgtgtaca  acatatgta  gtatgtgtg  3120
ctgtagttg  tctccagtt  agatgccct  actagcata  attcccaca  ggtgtgggt  3180
tcggcacaa  agtgacaaa  ttgaaagcc  agtaaatcc  gttggtgtt  ttagagagc  3240
taattagtg  agatctggt  tacctcaaa  tcacaaagc  tctcttcct  aattgaagt  3300
cctggccca  tgtcacaaa  taacatgtg  aaggcagct  gttgaagctt  3350



<210> 9954
<211> 189
<212> PRT
<213> Rattus norvegicus
<308> CAA48460
<400> 9954

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
  1               5                  10                  15
Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
             20                  25                  30
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
         35                  40                  45
Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
     50                  55                  60
Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
 65                  70                  75                  80
Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                 85                  90                  95
Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
             100                105                110
Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
         115                120                125
Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
     130                135                140
Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
 145                150                155                160
Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Glu Asp 
                 165                170                175
Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
             180                185



<210> 9955
<211> 1963
<212> DNA
<213> Homo sapiens
<308> NM_002524
<400> 9955

gaaacgtcc  gtgtgggag  ggcgggtct  ggtgcggct  ccgcatgac  cgtggttcg  60
aggcccacg  ggccggggc  gggactcag  cgcctggca  ccgactgat  acgtagcgg  120
cggggccgg  agtgccgct  cttggtggg  gctgttcat  gcggttccg  ggtctccaa  180
atttttccc  gtctgtggt  ctaaatctg  ccaaagcag  ggcagtgga  cttgaggtt  240
ttgctggtg  gaaatgact  agtacaaac  ggtggtggt  ggagcaggt  gtgttggga  300
aagcgcact  acaatccag  taatccaga  ccactttgt  gatgaatat  atcccacca  360
agaggattc  tacagaaaa  aagtggtta  agatggtga  acctgtttg  tggacatac  420
ggatacagc  ggacaagaa  agtacagtg  catgagaga  caatacatg  ggacaggcg  480
aggcttcct  tgtgtattt  ccatcaata  tagcaagtc  tttgcggat  ttaacctct  540
cagggagca  attaagcga  taaaagact  ggatgatgt  cctatggtg  tagtgggaa  600
caagtgtga  ttgccaaca  ggacagttg  tacaaaaca  gcccacgaa  tggccaaga  660
ttacgggat  ccattcatt  aaacctcag  caagaccag  cagggtgtt  aagatgctt  720
ttacacact  gtaagagaa  tacgccagt  ccgaatgaa  aaactcaac  gcagtgatg  780
tgggactca  ggttgtatg  gattgccat  tgtggtgat  taacaagat  cttttaaag  840
tttgtcaga  aagagccac  ttcaagctg  actgacacc  tggtcctga  ttcctggag  900
agaagtatt  ctgttgctg  cttcagtct  acagagaag  tcctgctac  tccccagct  960
tcagtagtt  agtacaata  tctctattt  agaagttct  agaataact  cctcctcac  1020
tggctgtct  accagagaa  gcacctctt  ttactccct  ttatttttc  gccctgggt  1080
cttccacag  acaaacaca  ctcaacaca  ctctgccac  ccaggtttt  catctgaaa  1140
gcagttcat  tctgaaaca  agaaccaaa  cgcaaacgt  aaattctat  gaaaacagt  1200
tcttgagct  taaagtagc  actgctggt  atttttttt  tctttttac  gttgaactt  1260
gaactatgc  taatttttg  agaaatgtc  taaattact  ttttgccaa  aatatagtt  1320
ttattgctg  ttggtttgt  tataatgtt  tcggctcta  tctctaaac  ggcatctgc  1380
ctagattca  aaatacaaa  atgaatact  aattttgag  ctatcctag  cttcacaac  1440
ttgacgtaa  taaatccaa  ttttcacag  gaagtgcct  tttcctaga  gtggtttgt  1500
gactccttt  taatatttc  gtggaatag  tgtctcaaa  atccttatg  atgaaatga  1560
tgtctgaga  acgtctgtg  cttatctac  attgaagga  agctatatc  atttgagag  1620
agatgccat  ttgtacatg  atgaaattg  ttttccaga  gcctgtttt  gggctttcc  1680
aggagaaag  tgaaactga  agcatatga  taatttcac  taataattt  tacctaatc  1740
ccacttttt  cataggtta  tacctatac  atgtatgta  tttgtttcc  ctagcttac  1800
gataaacct  atattcaat  aacttccat  tgtattcaa  tttgtgtca  accagaaag  1860
tctacattt  cagatgttc  aatattgta  aactttggt  cattgttat  taatagctg  1920
gatcagtga  tttcaaacc  caaatatag  atattaaca  att  1963



<210> 9956
<211> 189
<212> PRT
<213> Homo sapiens
<308> P01111
<400> 9956

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
  1               5                  10                  15
Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
             20                  25                  30
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
         35                  40                  45
Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
     50                  55                  60
Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
 65                  70                  75                  80
Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                 85                  90                  95
Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
             100                105                110
Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
         115                120                125
Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
     130                135                140
Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
 145                150                155                160
Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                 165                170                175
Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
             180                185



<210> 9957
<211> 864
<212> DNA
<213> Rattus norvegicus
<308> X68782
<400> 9957

ctgcaggag  caggcactg  gcttgtgag  cctgggtcc  cagtcaaga  ttcttgcaa  60
gcttctggc  acaccttta  agattacta  atgcactgg  tgaagcaga  gcctgaaca  120
ggactggta  ggataggac  gattaatcc  gcaaatggt  atactgaat  tgcagagaa  180
ttcaaaagc  gggccacac  gactgcaga  aaatcgtcc  acacagcct  catgcaact  240
agcagcctg  catctgaag  caccgcaac  tatttttgt  ccatttggg  tacagtggt  300
ccttttgat  actggggcc  aggagtcat  gtcacagtc  cctcagaga  tcagtcctc  360
ccaactgtc  tgcccctcg  ctcctgcga  agccccctg  ctgatgaga  tttggtggc  420
atgggctgc  tggcccggg  cttcctgcc  agctccatt  ccttctcct  gaactacca  480
aacaacact  aagtcatgc  gggtgtcag  accttccca  cactgagga  aggggacaa  540
tacacagct  cctcgcagg  gttactgtc  gccaaaaat  tccttgaag  ttcagatga  600
tacttggta  gcaaaatcc  ccatggcaa  aaaaacaaa  atctgcatg  gccgattcc  660
gctgtcgtt  agatgaacc  caatgtgag  gtgttcatt  caccacgtg  tgccttctc  720
ggccctgca  cccgcaagt  cagactcat  tgcgaggcc  ccaacttca  tcccaaaca  780
atcacagta  cctggctac  ggatgggaa  cctgtgaaa  ctggcttca  cacagagcc  840
gtgactgtc  aggccaaag  atcc  864



<210> 9958
<211> 2129
<212> DNA
<213> Homo sapiens
<308> BC009851
<400> 9958

ggcacgagg  tggactgga  ctggagaat  ctcttcttg  tggcagcag  cacagatgc  60
tactcccag  tgcagctgg  gcagtctgg  gctgaggtg  agaagactg  gtcctcagt  120
aaggtttcc  gcaaggctt  cggatacac  ttcacctac  gctacctgc  ctgggtgcg  180
caggccccc  gacaagcgc  tgagtggat  ggatggatc  cacctttca  tggtaacac  240
aactacgca  agaaattcc  ggacagagt  accattacc  gggacaggt  tatgaacac  300
gcctacatg  agctgagca  cctgagatc  gaggacaca  ccatgtatt  ctgtgcaag  360
gggtatagc  gcagctggg  tgatgcttt  gatatctgg  gccagggga  aatggtcac  420
gtctcttca  ggagtgcat  cgccccaac  cttttcccc  tcgtctcct  tgagaattc  480
ccgtcggat  cgagcagcg  ggccgttgg  tgcctcgca  aggacttcc  tcccgactc  540
atcactttc  cctggaaat  caagaacaa  tctgacatc  gcagcaccc  gggcttccc  600
tcagtcctg  gagggggca  gtacgcagc  acctcacag  tgctgctgc  ttccaagga  660
gtcatgcag  gcacagacg  acacgtggt  tgcaaagtc  agcacccca  cggcaacaa  720
gaaaagaac  tgcctcttc  agtgattgc  gagctgcct  ccaaagtga  cgtcttcgt  780
ccaccccgc  acggcttct  cggcaaccc  cgcaagtcc  agctcatct  ccaggccac  840
ggtttcagt  cccggcaga  tcaggtgtc  tggctgcgc  aggggaagc  ggtggggtc  900
ggcgtcacc  cggaccagg  gcaggctga  gccaaagag  ctgggccca  gacctacaa  960
gtgaccagc  cactgacca  caaagagag  gactggctc  gccagagca  gttcacctg  1020
cgcgtggat  acaggggcc  gaccttcca  cagaatgcg  cctccatgt  tgtccccga  1080
caagacaca  ccatccggg  cttcgccat  cccccatcc  ttgccagca  cttcctcac  1140
aagtccacc  agttgacct  cctggtcac  gacctgacc  cctatgaca  cgtgaccat  1200
tcctggacc  gccagaatg  cgaagctgt  aaaacccac  ccaacatct  cgagagcca  1260
cccaatgcc  ctttcagcg  cgtgggtga  gccagcatc  gcgaggatg  ctggaattc  1320
ggggagagg  tcacgtgca  cgtgaccca  acagacctg  cctcgccac  gaagcagac  1380
atctcccgg  ccaaggggg  ggccctgca  aggcccgat  tctacttgc  gccaccagc  1440
cgggagcag  tgaacctgc  ggagtcggc  accatcacg  gcctggtga  gggcttctc  1500
cccgcggac  tcttcgtgc  gtggatgca  agggggcag  ccttgtccc  ggagaagta  1560
gtgaccagc  ccccaatgc  tgagcccca  gccccaggc  ggtacttcg  ccacagcat  1620
ctgaccgtg  ccgaagagg  atggaacac  ggggagacc  acacctgcg  ggtggccca  1680
gaggccctg  ccaacaggg  caccgagag  accgtggac  agtccaccg  gggggaggt  1740
agcgccgac  aggagggct  tgagaacct  tgggccacc  cctccacct  catcgtcct  1800
ttcctcctg  gcctcttct  cagtaccac  gtcaccttg  tcaaggtga  atgatccca  1860
cagaagaac  tcggagacc  gagagagga  ctcaaaggg  cgctgcctc  gggtctggg  1920
tcctggcct  cgtggcctg  tggcacgtg  ttctcttcc  cgcccggcc  ccagttgtg  1980
gctctcaca  aggcttcct  ctcgaccgg  aggggctgg  tggcttgca  gccacgagg  2040
gggctctac  ccacactgc  ttgctgtgt  tacgcttgt  gccctgaaa  aaatatgca  2100
attttatcc  tgaaaaaaa  aaaaaaaaa  2129



<210> 9959
<211> 454
<212> PRT
<213> Homo sapiens
<308> P01871
<400> 9959

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
  1               5                  10                  15
Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
             20                  25                  30
Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
         35                  40                  45
Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
     50                  55                  60
Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
 65                  70                  75                  80
Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                 85                  90                  95
Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
             100                105                110
Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
         115                120                125
Ser Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln 
     130                135                140
Ile Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val 
 145                150                155                160
Thr Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr 
                 165                170                175
Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser 
             180                185                190
Gln Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln 
         195                200                205
Gln Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg 
     210                215                220
Val Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser 
 225                230                235                240
Thr Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val 
                 245                250                255
Thr Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr 
             260                265                270
Asn Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu 
         275                280                285
Ala Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys 
     290                295                300
Thr Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser 
 305                310                315                320
Arg Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro 
                 325                330                335
Pro Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys 
             340                345                350
Leu Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln 
         355                360                365
Arg Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met 
     370                375                380
Pro Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr 
 385                390                395                400
Val Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val 
                 405                410                415
Ala His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys 
             420                425                430
Ser Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp 
         435                440                445
Thr Ala Gly Thr Cys Tyr 
     450



<210> 9960
<211> 2450
<212> DNA
<213> Rattus norvegicus
<308> X69903
<400> 9960

gtcgaccca  tggggcggc  ttgcaccaa  ttcctgtcc  ccgtgagct  tctgatttt  60
ctatgggtg  ctggctctg  gggcatcaa  gtcctgggt  accccacct  cttctctga  120
tacatccgc  cttctacgt  tgagtggca  ctggatagc  ctgtggact  cagttctca  180
ctcctcctg  actacaggc  gctcttcga  ttctctgaa  acctcacat  cacccccaa  240
aacagtgcc  acaccgtgt  tgtgtgcca  atggccata  aggagccga  ccaggcaga  300
acatactgg  tggaactgt  gtctgagcg  ggacagctg  ggcaaggct  cttcaagcc  360
agtgacaat  tgaagcccc  agctccaga  aacctcaca  tccacacca  tgtctccaa  420
ggcctgctg  tgatgtgga  caacccata  ccatcgaac  acttcctgc  caaaggcct  480
atctgcatg  tcaacatct  cagagagga  aacccggcg  aattcaaag  ctataatgt  540
acctacacg  aacccaagc  gagcttccc  gtcaacacc  taacatcag  ggtgcgcta  600
agggcacgt  tgagggtct  gtcccagag  ttccctggc  tctggagtg  gtggagtcc  660
agcatcacg  ggtacaacc  cttccagct  cccctgctg  agcgcctcc  gctgggtgt  720
agcatctcc  gcatctgca  cctattgtt  tgcctgacc  gttacttca  cattatcaa  780
attaagaag  tatggtggg  ccagattcc  actccagca  gcagtccct  agcagccat  840
atcattcag  acacgaagg  gctcctctg  gagaagcag  cccgaagcc  ggagtcaac  900
aagagccgg  actggaaga  ttgtctaac  aagctgctg  cctgcttgc  ggagcatag  960
gtgaagaaa  agagagaat  cccgaaggc  gccaaaacc  agcctctcc  gagtcctga  1020
aaagcaggc  ggtatcctg  ggaggtcag  aggaccgtc  tctggccag  gaacgttca  1080
gtcagtgtg  tgcgctgta  ggagctgtt  gaggcccca  tacagaatg  ggaggagga  1140
gaggatgag  tggtcaaag  ggacctgag  atgtcacct  agaacagcg  agggggctt  1200
caggagagt  aggcagaca  catggcccg  ctcactgag  acctgtttt  agacttgct  1260
ggggctgag  atggaggcg  tggccagtc  agcatggca  agtcatcct  ccttctgcc  1320
tcagaaagt  ggcaagctt  tacgtcctg  gcctgcttc  ccacggggc  cagtgagac  1380
acatgccag  tcacagggc  gcagcctcc  cacccagac  ctgagagag  aactggcac  1440
gcctgcaca  aggtccccc  tgtcatttc  gacaatcct  cctaccgga  ttttagtga  1500
ttctccagc  ccgccccaa  tcctggaga  ctggcttca  aacagaagc  ggctggaca  1560
ctggaagaa  gggatcttc  gagcccggt  gacccccat  cttcagggc  accaatgca  1620
caagcggag  gctgggagc  gatccttca  atgagtgtc  tgcagcacg  gacagctgg  1680
tccacccca  cccctacca  tggctacca  gagtttgtg  aggcagtga  gcagggtgc  1740
tcccaggcc  ggtgggtgc  tggtgtcgg  ccttctgga  acactggtt  caaggcttt  1800
tcgagcctg  tcagcagca  tggcgtctg  acggacaca  cagcagcag  gactgacag  1860
ggatgtgga  ggtacaagc  cttccagaa  cctgttcct  accagtccc  caactccat  1920
cccttattc  ccttcggac  ggacatgga  ctgccaccc  gtcccctga  ctcagcccc  1980
cccaatagc  ccccagaat  ccttggtct  gagctgggg  tcaaaggag  cacctggct  2040
aaggcccct  ctccttcag  gcaggtgcc  aagcccttt  gggatgacc  gggccttgg  2100
attgtgtac  cgtccctca  ctgccatct  tgtggccac  tgaagcaac  ccacagcca  2160
gaggaagat  gtcagatcc  tgtcgttgc  tgccctggc  gcggctgtt  ctatgatga  2220
aaatcacca  ccttgggga  tctctcggg  accttggag  gctgtcctg  ggaaatgtc  2280
caggaagcc  acctcacct  agcacccag  acaccctcc  atttgtcag  ggtgcaagg  2340
cctggccac  ctcctgttc  cagccagac  actgaggta  ctgtgggca  tctgggcgt  2400
actgtgtct  aggtgagtg  gctgttgtt  ctgaggtct  tgctgtcgac  2450



<210> 9961
<211> 800
<212> PRT
<213> Rattus norvegicus
<308> CAA49528
<400> 9961

Met Gly Arg Leu Cys Thr Lys Phe Leu Ser Ser Val Ser Cys Leu Ile 
  1               5                  10                  15
Leu Leu Trp Val Thr Gly Ser Gly Gly Ile Lys Val Leu Gly Asp Pro 
             20                  25                  30
Thr Cys Phe Ser Asp Tyr Ile Arg Thr Ser Thr Cys Glu Trp Gln Leu 
         35                  40                  45
Asp Ser Thr Val Asp Cys Ser Ser Gln Leu Leu Leu Asp Tyr Arg Leu 
     50                  55                  60
Leu Phe Glu Phe Ser Glu Asn Leu Thr Cys Thr Pro Lys Asn Ser Ala 
 65                  70                  75                  80
Asp Thr Val Cys Val Cys Gln Met Ala Ile Glu Glu Pro Ile Gln Ala 
                 85                  90                  95
Asp Thr Tyr Trp Leu Glu Leu Trp Ser Glu Arg Gly Gln Leu Trp Gln 
             100                105                110
Gly Ser Phe Lys Pro Ser Asp Asn Val Lys Pro Pro Ala Pro Asp Asn 
         115                120                125
Leu Thr Leu His Thr Asn Val Ser Asn Gly Leu Leu Leu Met Trp Ser 
     130                135                140
Asn Pro Tyr Pro Ser Asn Asn Phe Leu His Lys Gly Leu Ile Cys Met 
 145                150                155                160
Val Asn Ile Ser Arg Glu Asp Asn Pro Ala Glu Phe Lys Val Tyr Asn 
                 165                170                175
Val Thr Tyr Thr Glu Pro Lys Leu Ser Phe Pro Val Asn Thr Leu Thr 
             180                185                190
Ser Gly Val Arg Tyr Arg Ala Arg Val Arg Val Leu Ser Gln Ser Phe 
         195                200                205
Pro Gly Ile Trp Ser Glu Trp Ser Pro Ser Ile Thr Trp Tyr Asn His 
     210                215                220
Phe Gln Leu Pro Leu Leu Gln Arg Leu Pro Leu Gly Val Ser Ile Ser 
 225                230                235                240
Cys Ile Cys Ile Leu Leu Phe Cys Leu Thr Cys Tyr Phe Ser Ile Ile 
                 245                250                255
Lys Ile Lys Lys Ile Trp Trp Asp Gln Ile Pro Thr Pro Ala Arg Ser 
             260                265                270
Pro Leu Ala Ala Ile Ile Ile Gln Asp Thr Lys Val Leu Leu Trp Glu 
         275                280                285
Lys Gln Thr Arg Ser Gln Glu Ser Thr Lys Ser Arg His Trp Lys Thr 
     290                295                300
Cys Leu Thr Lys Leu Leu Pro Cys Leu Leu Glu His Arg Val Lys Lys 
 305                310                315                320
Glu Arg Glu Ser Pro Lys Ala Ala Lys Thr Lys Pro Leu Gln Ser Pro 
                 325                330                335
Glu Lys Ala Gly Trp Tyr Pro Ala Glu Val Ser Arg Thr Val Leu Trp 
             340                345                350
Pro Glu Asn Val His Val Ser Val Val Arg Cys Met Glu Leu Phe Glu 
         355                360                365
Ala Pro Val Gln Asn Val Glu Glu Glu Glu Asp Glu Met Val Lys Gly 
     370                375                380
Asp Leu Ser Met Ser Pro Glu Asn Ser Gly Gly Gly Phe Gln Glu Ser 
 385                390                395                400
Gln Ala Asp Ile Met Ala Arg Leu Thr Glu Asn Leu Phe Ser Asp Leu 
                 405                410                415
Leu Gly Ala Glu Asn Gly Gly Val Gly Gln Ser Ser Met Ala Glu Ser 
             420                425                430
Ser Ser Leu Leu Pro Ser Glu Ser Gly Gln Ala Ser Thr Ser Trp Ala 
         435                440                445
Cys Phe Pro Thr Gly Pro Ser Glu Thr Thr Cys Gln Val Thr Gly Gln 
     450                455                460
Gln Pro Pro His Pro Asp Pro Glu Arg Ala Thr Gly Thr Ala Cys Thr 
 465                470                475                480
Gln Val Pro Leu Val Ile Ser Asp Asn Pro Ala Tyr Arg Ser Phe Ser 
                 485                490                495
Asp Phe Ser Ser Pro Ala Pro Asn Pro Gly Glu Leu Ala Ser Glu Gln 
             500                505                510
Lys Gln Ala Gly His Leu Glu Glu Gly Asp Leu Leu Ser Pro Val Asp 
         515                520                525
Pro His Ser Ser Gly Pro Pro Met Gln Gln Ala Glu Ser Trp Glu Gln 
     530                535                540
Ile Leu His Met Ser Val Leu Gln His Gly Thr Ala Gly Ser Thr Pro 
 545                550                555                560
Ala Pro Thr Ser Gly Tyr Gln Glu Phe Val Gln Ala Val Lys Gln Gly 
                 565                570                575
Ala Ser Gln Ala Arg Trp Val Pro Gly Val Gly Pro Ser Gly Asp Thr 
             580                585                590
Gly Tyr Lys Ala Phe Ser Ser Leu Leu Ser Ser Ser Gly Val Cys Thr 
         595                600                605
Asp Thr Ala Ala Ala Gly Thr Asp Ser Gly Cys Gly Gly Tyr Lys Pro 
     610                615                620
Phe Gln Asn Pro Val Pro Asn Gln Ser Pro Asn Ser Met Pro Leu Phe 
 625                630                635                640
Thr Phe Gly Leu Asp Met Glu Leu Pro Pro Ser Pro Leu Asn Ser Ala 
                 645                650                655
Pro Pro Asn Ser Thr Pro Glu Cys Leu Gly Leu Glu Leu Gly Leu Lys 
             660                665                670
Gly Gly Thr Trp Leu Lys Ala Pro Pro Pro Ser Glu Gln Val Pro Lys 
         675                680                685
Pro Phe Gly Asp Asp Leu Gly Leu Gly Ile Val Tyr Ser Ser Leu Thr 
     690                695                700
Cys His Leu Cys Gly His Leu Lys Gln His His Ser Gln Glu Glu Asp 
 705                710                715                720
Gly Gln Ile His Val Val Ala Cys Pro Gly Cys Gly Cys Cys Tyr Asp 
                 725                730                735
Glu Lys Ser Pro Ser Leu Gly Asn Leu Ser Gly Thr Leu Glu Ser Cys 
             740                745                750
Pro Gly Glu Met Ser Gln Glu Ala Asn Leu Thr Leu Ala Pro Arg Thr 
         755                760                765
Pro Ser Asn Leu Ser Gly Val Gln Gly Pro Gly His Ser Pro Val Pro 
     770                775                780
Ser Gln Thr Thr Glu Val Pro Val Gly Thr Leu Gly Val Thr Val Ser 
 785                790                795                800



<210> 9962
<211> 3597
<212> DNA
<213> Homo sapiens
<308> NM_000418
<400> 9962

ggcgaatgg  gcaggggcg  gcagataat  aaagattta  acacagctg  aagaaatca  60
agagaagcc  ggcgtggtg  ctcatgcct  taatcccag  acttttgga  gctgaggcg  120
gcagatcac  tgagatcag  agttcgaga  cagcctggt  ccttggcat  tcccaatgg  180
gtggctttg  tctgggctc  tgttccctg  gagctgcct  gtcctgctg  aggtggcaa  240
ctctgggaa  atgaaggtc  tgcaggagc  cacctgcgt  tccgactac  tgagcatct  300
tacttgcga  tggaagatg  atggtccca  caattgcag  accgagctc  gcctgttgt  360
ccagctggt  tttctgctc  ccgaagccc  cacgtgtat  cctgagaac  acggaggcg  420
ggggtgcgt  tgccacctg  tcatggatg  cgtggtcag  gcggataac  atacactgg  480
cctgtgggc  gggcagcag  tgctgtgga  gggctcctt  aagcccagc  agcatgtga  540
acccagggc  ccaggaaac  tgacagttc  caccaatgt  tccgacact  tgctgctga  600
ctggagcaa  ccgtatccc  ctgacaatt  cctgtataa  catctcacc  atgcagtca  660
catttggag  gaaaacgac  cggcagatt  cagaatcta  aacgtgacc  acctagaac  720
ctccctccg  atcgcagcc  gcaccctga  gtctgggat  tcctacagg  cacgggtga  780
ggcctgggc  cagtgctat  acaccacct  gagtgagtg  agccccagc  ccaagtggc  840
caactccta  agggagccc  tcgagcagc  cctcctgct  ggcgtcagc  tttcctgca  900
tgtcatcct  gccgtctgc  tgttgtgct  tgtcagcat  accaagatt  agaaagaat  960
gtgggatca  attcccaac  cagcccgca  ccgcctcgt  gctataata  tccaggatg  1020
tcaggggtc  cagtgggag  agcggtccc  aggccagga  ccagccaag  gcccacact  1080
gaagaattg  cttaccaag  tcttgccct  ttttctgga  cacaacatg  aaagggatg  1140
agatcctca  aaggctgcc  aagagatgc  tttccaggg  tctggaaaa  cagcatggt  1200
cccagtgga  atcagcaag  cagtcctct  gccagagag  atcagcgtg  tgcgatgtg  1260
ggagttgtt  gaggccccg  tggagtgtg  ggaggagga  gaggtagag  aagaaaaag  1320
gagcttctg  gcatcgcct  agagcagca  ggatgactt  caggaggga  gggagggca  1380
tgtggcccg  ctaacagag  gcctgttcc  ggacctgct  ggagaggag  atgggggct  1440
ttgccagca  gacatgggg  agtcatgcc  tcttccacc  tcgggaagt  cgagtgctc  1500
catgccctg  gatgagttc  caagtgcag  gcccaagga  gcacctccc  ggggcaagg  1560
gcagcctct  cacctggag  caagtcctc  tgccagccc  acccagagt  cagacaacc  1620
gacttgcac  gagacgccc  tcgtcatcg  aggcaaccc  gcttaccgc  gcttcagca  1680
ctccctgag  cagtcaccg  gtcccagag  gctgggtcc  gacccactg  tggccagac  1740
cctggagga  gtagaaccc  agatgccct  tgtccccca  ctctctgag  caaccactg  1800
gccccaacc  gagccagaa  cctgggagc  gatcctccg  cgaaatgtc  tccagcatg  1860
ggcagctgc  gcccccgtc  cggccccca  cagtggcta  caggagttt  tacatgcgg  1920
ggagcaggg  ggcacccag  ccagtgcgg  ggtgggctt  ggtccccca  gagaggctg  1980
ttacaaggc  ttctcaagc  tgcttgcca  cagtgctgt  tccccagag  aatgtgggt  2040
tggggctag  agtggggaa  aggggtata  gcctttcca  gacctcatt  ctggctgcc  2100
tggggaccc  gccccagtc  ctgtcccct  gttcacctt  ggactggac  gggagccac  2160
tcgcagtcc  cagagctca  atctcccaa  cagctcccc  gagcacctg  gtctggagc  2220
gggggaaaa  gtagaggac  tgccaaagc  cccacttcc  caggagcag  ccacagacc  2280
ccttgtgga  agcctgggc  gtggcattg  ctactcagc  cttacctgc  acctgtgcg  2340
ccacctgaa  cagtgtcat  gccaggagg  tggtggcca  acccctgtc  tggccagtc  2400
ttgctgtgg  tgctgctgt  gagacaggt  ctcgccccc  acaaccccc  tgagggccc  2460
agacccctc  ccaggtggg  ttccactgg  ggccagtct  tgtccggcc  ccctggcac  2520
ctcgggcat  tcagagaag  gtaaatcct  atcatcctt  catcctgcc  ctggcaatg  2580
tcagagctc  agccagacc  ccaaaatcg  gaactttgt  tccgtggga  ccacataca  2640
gagggtctc  taggtgcat  tcctcttgt  gctgagtct  cagatgagg  ctagggctt  2700
tccatgcct  ggaaatgcc  cctcctgga  ggcagccag  ctggcagat  tccaaaaga  2760
ttgaagaac  atggtatga  ggtgattgg  cccactgac  ttggcctaa  actgggctg  2820
agagactgg  ccccgccca  cattgggct  ggctcgcca  atcccatga  agtagaggg  2880
actgggtcg  cgtgcccca  ggcaggccc  tgcaggaaa  ctgaggccc  tgggcacct  2940
gacttgtga  cgagttgtt  gctgctccc  ccacagctt  tgcagcaga  tgtccctgt  3000
gtaactgcc  aaggcatgt  ttgcccacc  gatcatggc  cacgtggag  cccacctgc  3060
tctgtctca  tgaactaga  gccgagcct  gaaactaac  cagccatca  gggaatgac  3120
tgggcggcc  tgggaaatc  atgagaaat  gaacttcag  gagggtggt  attgcctag  3180
ggtgctcat  catttaaca  agcttcctt  ggttgatgc  ggaggcaga  tcccggctg  3240
caaggggtg  tcagttaag  ggagcaaca  aggacatga  aaattgcta  gactaaagc  3300
gggacaatt  gctgccaaa  acccatgcc  agctgtatg  ctgggggct  ctcgtatgc  3360
tggaacccc  agaataaat  tgctcagcc  ccctgtggg  cgggcaatc  agacagcag  3420
cataaggca  cagttaccc  gcatgttgg  ccagacctc  ggtgctagg  aaggcggga  3480
ccttgggtt  agtaatgct  gtctgtgtg  tttagtttc  tcacctgtt  tctgtgttt  3540
ctgaggaga  tggaacaga  ggggtggag  tttgtataa  taaagtttc  ttgtctc  3597



<210> 9963
<211> 825
<212> PRT
<213> Homo sapiens
<308> P24394
<400> 9963

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
  1               5                  10                  15
Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
             20                  25                  30
Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
         35                  40                  45
Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
     50                  55                  60
Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
 65                  70                  75                  80
Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                 85                  90                  95
Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
             100                105                110
Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
         115                120                125
Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
     130                135                140
Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
 145                150                155                160
Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                 165                170                175
Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
             180                185                190
Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
         195                200                205
Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
     210                215                220
Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
 225                230                235                240
Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                 245                250                255
Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
             260                265                270
Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
         275                280                285
Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
     290                295                300
Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
 305                310                315                320
Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                 325                330                335
Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
             340                345                350
Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
         355                360                365
Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
     370                375                380
Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
 385                390                395                400
Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                 405                410                415
Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
             420                425                430
Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
         435                440                445
Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
     450                455                460
Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
 465                470                475                480
Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                 485                490                495
Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
             500                505                510
Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
         515                520                525
Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
     530                535                540
Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
 545                550                555                560
His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                 565                570                575
Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
             580                585                590
Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
         595                600                605
Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
     610                615                620
Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
 625                630                635                640
Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                 645                650                655
Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
             660                665                670
Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
         675                680                685
Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
     690                695                700
Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
 705                710                715                720
Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                 725                730                735
Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
             740                745                750
Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
         755                760                765
Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
     770                775                780
Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
 785                790                795                800
Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                 805                810                815
Val Gly Pro Thr Tyr Met Arg Val Ser 
             820                825



<210> 9964
<211> 645
<212> DNA
<213> Rattus norvegicus
<308> X70062
<400> 9964

cgaaatgac  gagctgtca  ctaaccatg  tggcagtgc  ggggacgga  aatcccttc  60
agtatgact  tgaaaccgt  cgcaaagga  gcctgatct  cgcgggcct  gccttcgtc  120
tgggactcc  cattctcct  agcaaaaga  tccgctgtg  gggcagtaa  aagcatagg  180
aggtcaatg  agatgagct  tgacggaag  gccggcagt  ccaccggtg  atgggcaca  240
tgatgccac  tccccagcc  ggcaccacg  accccacca  ggtcagcac  ggctgaagg  300
agtgccagg  ttactggac  cctcatggt  atccctcat  cctctagat  gttaacttc  360
tctctcccc  ccccaacct  tcttacacc  aactcccta  tccaagttg  ggtacatgt  420
caatctcat  gccctggtt  tcaatgaat  gctctacaa  aatctgcca  caaaagcag  480
ctcagtgtg  tcatctacg  gagtgtatc  ttcgcccct  aacagttac  ctggggaca  540
ttaccctgc  tgacttctg  gcgccctgc  aaagtctga  gctgttaag  tgaaggtga  600
ttggtggac  gggtcctgc  gctgctgct  ctgctgctg  tgctg  645



<210> 9965
<211> 66
<212> PRT
<213> Rattus norvegicus
<308> Q04679
<400> 9965

Met Thr Glu Leu Ser Ala Asn His Gly Gly Ser Ala Lys Gly Thr Glu 
  1               5                  10                  15
Asn Pro Phe Glu Tyr Asp Tyr Glu Thr Val Arg Lys Gly Gly Leu Ile 
             20                  25                  30
Phe Ala Gly Leu Ala Phe Val Val Gly Leu Leu Ile Leu Leu Ser Lys 
         35                  40                  45
Arg Phe Arg Cys Gly Gly Ser Lys Lys His Arg Gln Val Asn Glu Asp 
     50                  55                  60
Glu Leu 
 65



<210> 9966
<211> 1155
<212> DNA
<213> Homo sapiens
<308> X86400
<400> 9966

gcaaaagaa  tccgggccc  gctgtattt  tacttgagc  tggagaggc  ggtggtgac  60
gaggaggga  acaggcagg  aggtgaggg  agcagcggt  tctgacgcc  gctttatta  120
aagcatgag  tggcacgag  caggagttg  cgatgccac  tgggggtca  attgagtct  180
gagcttcct  cagcccaag  gctggcagt  acggggaca  aggtctaaa  cccagggaa  240
aaggggagg  gccagaggc  gggccatgc  tggcttccc  gctggcccc  gtgcagtgg  300
tggcaccgc  gaggctgct  ttacggctc  tcttcattg  tttgcctgc  cttcttatt  360
cccccacag  ggaatcttc  gctgaggag  atgaggagc  ccacgatga  ggccagtcc  420
gcgaagatc  ggcccccat  gcgaacggt  tcatagtca  agtagaacg  gtccacgtc  480
cccttgggg  tgccgccac  gtccatcga  aacccagtc  tttccccag  tgaatgggc  540
gcctccact  ccctcttcc  gcaagaagt  ctcaagcct  tttgatttt  gtgcaataa  600
gtacagctt  gcataagag  gaaattggg  tagcttaaa  ggatccata  actttcttc  660
aattttaag  gagaatctt  taaacacct  ttaaattta  tgtagcagt  tgagaatct  720
aaattatgt  ccactcgtt  atttgttca  tcatccatc  cttttccca  gaatatttc  780
tttgtttat  cagctagtt  tattaactg  tttaatcca  gcattggga  ataatgata  840
gcaagatat  attcctgtg  aaacttctt  caggcacta  agatataga  gatgaatta  900
aggaacata  aattggagg  gattgaata  ttaaaggca  tggccatag  gatggcaaa  960
aggaagtag  gatagagtc  ttaggactt  gtgccaatt  aatacgggg  gagtgagag  1020
agatggctt  gggatgtcc  caagttcct  gcttattta  tcattatgc  tttattgga  1080
gactatcat  ttttaggca  tgttatgtt  caggcattg  cggaattca  cttggactt  1140
accaggctg  actgg  1155



<210> 9967
<211> 126
<212> PRT
<213> Homo sapiens
<308> Q15332
<400> 9967

Met Pro Pro Gly Gly His Ile Glu Ser Gly Ala Ser Phe Ser Pro Ser 
  1               5                  10                  15
Ala Gly Ser Asp Gly Asp Lys Gly Leu Lys Pro Arg Glu Glu Gly Glu 
             20                  25                  30
Ala Pro Glu Ala Gly Pro Cys Leu Ala Ser Gln Leu Ala Pro Val Gln 
         35                  40                  45
Trp Val Ala Pro Pro Arg Leu Leu Leu Arg Leu Ile Phe Ile Asp Leu 
     50                  55                  60
Pro Ala Leu Leu Ile Ala Pro Thr Ala Glu Ser Ser Ala Glu Glu Asp 
 65                  70                  75                  80
Glu Glu Pro His Asp Glu Gly Gln Ser Ser Glu Asp Gln Ala Pro Ile 
                 85                  90                  95
Ala Asn Gly Leu Ile Val Ile Val Glu Arg Val His Val Pro Leu Gly 
             100                105                110
Ala Ala Ala Thr Val His Arg Gln Pro Ser His Phe Pro Arg 
         115                120                125



<210> 9968
<211> 1706
<212> DNA
<213> Rattus norvegicus
<308> X70662
<400> 9968

caccagcct  ctgaccaca  ggatctggc  gcttaatca  ccgagatca  aacctggga  60
gattgggga  gctgatatg  gctccagct  ctgagacaa  ttccagctt  gctgtttac  120
tctttgggt  ccagggact  tgtcctaca  ctcagcctc  cctgccact  tgtgtgggt  180
ctgaagtca  ctgctggga  tcctccgaa  gcatccagg  aggggggca  gaggggtta  240
aagacagcc  aaatcccct  caactgctc  ccctctgcc  accgcctgt  ctgtggggt  300
ctgagagga  cttgcgctg  ccggggaag  aatgcaagt  tccatagcc  gcacagagc  360
caatttgaa  agtcgaaat  gtgaggacc  acttctgag  aagcagagc  ccaccgccc  420
caatgtggt  aacgcagcc  gggccaaat  ccgcactgt  gctatcatc  ctcgcagcc  480
ggggacctt  acccctcag  atcacattt  tctcaaaga  tccactgca  agcagactg  540
catgaaata  aggaatctt  ggaaatcag  actcagagt  tcgtgcttg  gtcttggaa  600
atgggtgac  ttcggaggt  aaatttcag  tgaggttgc  gaacggctg  tgacaattg  660
ctatgagag  ggagttaat  tcttcgaca  tgcagaagt  tatgctgct  ggaaggctg  720
ggtgattct  gggagcatc  tcaagaaga  aggctggag  aggtcaagc  tggtcatca  780
aaccaaact  tactggggt  gaaaagccg  aacagaaag  ggattgtca  gaaagcaca  840
cattgaagg  ctgaaaggc  ccctccaga  gctgcaact  gaatatgtg  acgtggtct  900
tgcaaatcg  ccagacagc  acaccccca  ggaagaaat  gttcgagcc  tgacgcacg  960
gatcaacca  ggcatggca  tgtactggg  cacctcgag  tggagcgcg  tggagatca  1020
ggaagccta  tctgtcgcg  ggcagttca  catgatccc  cctgtctgt  agcaagctg  1080
gtatcatct  ttccagaga  aaaaggtgg  ggtccagct  ccagagctc  accataaaa  1140
aggggttgg  gcaatgaca  ggtctccac  tgcttgtgg  attatttca  gaaaatatg  1200
aaatggggt  ccagaaagt  ctagagctt  actgaagtg  taccagtgg  tgaaggaaa  1260
gattgtaag  gaagaaggg  gaaaacagc  aaacaagct  aaagacctc  ctccaattg  1320
tgaacgcct  ggatgcaca  tacctcagc  ggctgtggc  tggtgcctg  gaaacgagg  1380
tgtgagctc  gtgctgctg  gatcatcca  tcctgaaca  ctcattgaa  accttggtg  1440
cattcaggt  ctccctaag  tgacatcac  tgtggtaaa  gagattgat  acatattgc  1500
caacaagcc  tacagcaaa  aggactata  atcctaagg  aatgcatga  ccacttaag  1560
tgcatgagt  aatcctggt  ggtaggcgg  gcagaacgg  cttaccagc  actcttttc  1620
atcacttag  agcttgctg  tcaacctct  gtgtcccag  attctctga  gtctctgct  1680
ttgctacca  tgtgcaccc  gaattc  1706



<210> 9969
<211> 401
<212> PRT
<213> Rattus norvegicus
<308> Q63277
<400> 9969

Met Gln Val Ser Ile Ala Cys Thr Glu His Asn Leu Lys Ser Arg Asn 
  1               5                  10                  15
Gly Glu Asp Arg Leu Leu Ser Lys Gln Ser Ser Thr Ala Pro Asn Val 
             20                  25                  30
Val Asn Ala Ala Arg Ala Lys Phe Arg Thr Val Ala Ile Ile Ala Arg 
         35                  40                  45
Ser Leu Gly Thr Phe Thr Pro Gln His His Ile Ser Leu Lys Glu Ser 
     50                  55                  60
Thr Ala Lys Gln Thr Gly Met Lys Tyr Arg Asn Leu Gly Lys Ser Gly 
 65                  70                  75                  80
Leu Arg Val Ser Cys Leu Gly Leu Gly Thr Trp Val Thr Phe Gly Gly 
                 85                  90                  95
Gln Ile Ser Asp Glu Val Ala Glu Arg Leu Met Thr Ile Ala Tyr Glu 
             100                105                110
Ser Gly Val Asn Leu Phe Asp Thr Ala Glu Val Tyr Ala Ala Gly Lys 
         115                120                125
Ala Glu Val Ile Leu Gly Ser Ile Ile Lys Lys Lys Gly Trp Arg Arg 
     130                135                140
Ser Ser Leu Val Ile Thr Thr Lys Leu Tyr Trp Gly Gly Lys Ala Glu 
 145                150                155                160
Thr Glu Arg Gly Leu Ser Arg Lys His Ile Ile Glu Gly Leu Lys Gly 
                 165                170                175
Ser Leu Gln Arg Leu Gln Leu Glu Tyr Val Asp Val Val Phe Ala Asn 
             180                185                190
Arg Pro Asp Ser Asn Thr Pro Met Glu Glu Ile Val Arg Ala Met Thr 
         195                200                205
His Val Ile Asn Gln Gly Met Ala Met Tyr Trp Gly Thr Ser Arg Trp 
     210                215                220
Ser Ala Met Glu Ile Met Glu Ala Tyr Ser Val Ala Arg Gln Phe Asn 
 225                230                235                240
Met Ile Pro Pro Val Cys Glu Gln Ala Glu Tyr His Leu Phe Gln Arg 
                 245                250                255
Glu Lys Val Glu Val Gln Leu Pro Glu Leu Tyr His Lys Ile Gly Val 
             260                265                270
Gly Ala Met Thr Trp Ser Pro Leu Ala Cys Gly Ile Ile Ser Gly Lys 
         275                280                285
Tyr Gly Asn Gly Val Pro Glu Ser Ser Arg Ala Ser Leu Lys Cys Tyr 
     290                295                300
Gln Trp Leu Lys Glu Arg Ile Val Ser Glu Glu Gly Arg Lys Gln Gln 
 305                310                315                320
Asn Lys Leu Lys Asp Leu Ser Pro Ile Ala Glu Arg Leu Gly Cys Thr 
                 325                330                335
Leu Pro Gln Leu Ala Val Ala Trp Cys Leu Arg Asn Glu Gly Val Ser 
             340                345                350
Ser Val Leu Leu Gly Ser Ser Thr Pro Glu Gln Leu Ile Glu Asn Leu 
         355                360                365
Gly Ala Ile Gln Val Leu Pro Lys Met Thr Ser His Val Val Asn Glu 
     370                375                380
Ile Asp Asn Ile Leu Arg Asn Lys Pro Tyr Ser Lys Lys Asp Tyr Arg 
 385                390                395                400
Ser 
                 405



<210> 9970
<211> 2620
<212> DNA
<213> Homo sapiens
<308> U33428
<400> 9970

agggaccgt  cgctgcctg  ggaagcaat  caagtctcc  tagcctgca  agagcacaa  60
ttgaagagt  ggaatggtg  ggaccgact  ctgagcaag  agagctcca  cgcccccaa  120
gtggtgaac  cagcccggg  caaattccg  acggtcgct  tcatcgcgc  cagcctggg  180
acgttcacg  ctcagcatc  catttctct  aaagagtcc  ccgcaaagc  gactggcat  240
aaatatagg  atcttggaa  atcaggact  agagtttct  gcttgggtc  tggaacatg  300
gtgacattt  gaggtcaaa  ttcagatga  gttgctgaa  ggctgatga  catcgccta  360
gaaagtggt  ttaacctct  tgatactgc  gaagtctat  ctgctggaa  ggctgaagt  420
attctgggg  gcatcatca  gaagaaagg  tggaggagg  ccagtctgg  cataacaac  480
aaactctac  ggggtggaa  agctgaaac  gaaagaggg  tgtcaagaa  gcatattat  540
gaaggattg  agggctccc  ccagaggct  cagctcgag  atgtggatg  ggtctttgc  600
aatcgaccg  acagtaaca  tcccatgga  gaaattgtc  gagccatga  acatgtgat  660
aaccaaggc  tggcgatgt  ctggggcac  tcgagatgg  gtgctatgg  gatcatgga  720
gcctattct  tagcaagac  gttcaatat  atcccaccg  tctgtgaac  agctgagta  780
catcttttc  agagagaga  agtggaggt  cagctgcca  agctctacc  caaaatagg  840
gttggcgca  tgacatggt  tccacttgc  tgtggaatc  tctcaggaa  atacggaaa  900
ggggtgcct  aaagttcca  ggcttcact  aagtgctac  agtggttga  agaaagaat  960
gtaagtgaa  aagggagaa  acagcaaaa  aagctaaaa  acctttccc  aattgcgga  1020
cgtctggga  gcacactac  tcagctagc  gttgcgtgg  gcctgagaa  tgaaggtgt  1080
agttctgtg  tcctgggat  atccactcc  gaacaactc  ttgaaaacc  tggtgccat  1140
caggttctc  caaagatga  atcacatgt  gtaaatgag  ttgataaca  actgcgcaa  1200
aagccctac  gcaagaagg  ctatagatc  taaggcaat  catgaacca  agaagctgc  1260
tggttaaaa  agcggcctg  gcccagtac  gaaaggtgt  actaaccag  cttttgaat  1320
acttagcag  ttgctcgtc  acctctagt  tccctccct  gattctttg  ggtgtctgc  1380
gtcgctacc  ctgtgcaca  ctgaaaact  acaaccaag  aaatccatt  tattttctt  1440
tcttggact  gagtcacct  ttcttgcat  gctgtatac  cctcatgct  atgcaatgg  1500
aagaatatg  gggccaggg  gtgtggtac  accttcagg  atttggtaa  tcaaagaag  1560
ctgtacaga  atatttttt  aaaaagaac  aaatccaca  atgcaatgt  agttgcgta  1620
gaaacagag  agatagact  aattcagtg  aggaaagga  ttgagagat  tttcttagt  1680
aatagatta  tgttaagta  atagttatt  aaaatatat  tcactgcaa  aaaaaaaaa  1740
gcagtatct  cactcaaaa  tcttgcttg  aagaataag  agaaagaat  ttatatatt  1800
tttttctat  ttcacattc  tactaacaa  ttttgttcc  tttgttatt  aataaaaca  1860
aaatttcta  gtatttgct  tattacctt  caaatattt  ctgttgctt  gccccaaga  1920
tggccttgt  caacttatc  agaatgtct  ttaggattc  aatgttatg  ccacttaca  1980
gtagagaca  taaaaggat  aatacccaa  ctttagtga  aatgcagct  atttatgaa  2040
gagagggct  cactgctat  gaaacttag  ttcaaagaa  atgcaatgt  tctgcaatt  2100
ggtgttcat  ttttactac  ttttattaa  acctgcttt  tactttcaa  tgcttgtag  2160
cacaacttc  gcaagttta  atatttgag  tttacaaat  aacatacac  tgctgtttt  2220
taagtaaac  tgtaaaata  ccaggaagg  aaatgttca  tgtttaatt  gcactggga  2280
tttataata  aatgtttgg  atttttgag  cattgttaa  atgaaagtc  accactggc  2340
ttgtgaaaa  tgctatgtc  ctattcaga  tatgctggg  aaattaact  gcctagtga  2400
aagcaaaat  ttaaagaaa  aacttctgg  tctataatc  tattatatg  actaaacta  2460
atgcatgaa  gttctttgc  tggattaat  gggcttacc  ttgttgcac  cgaaatctg  2520
ggtgtatct  gccctgcca  tattggcta  ttaccctca  taatatccc  cttgagaaa  2580
attgtgaga  tatactgtg  caatatctg  aaaaagagag  2620



<210> 9971
<211> 419
<212> PRT
<213> Homo sapiens
<308> Q14722
<400> 9971

Met Leu Ala Ala Arg Thr Gly Ala Ala Gly Ser Gln Ile Ser Glu Glu 
  1               5                  10                  15
Asn Thr Lys Leu Arg Arg Gln Ser Gly Phe Ser Val Ala Gly Lys Asp 
             20                  25                  30
Lys Ser Pro Lys Lys Ala Ser Glu Asn Ala Lys Asp Ser Ser Leu Ser 
         35                  40                  45
Pro Ser Gly Glu Ser Gln Leu Arg Ala Arg Gln Leu Ala Leu Leu Arg 
     50                  55                  60
Glu Val Glu Met Asn Trp Tyr Leu Lys Leu Cys Asp Leu Ser Ser Glu 
 65                  70                  75                  80
His Thr Thr Val Cys Thr Thr Gly Met Pro His Arg Asn Leu Gly Lys 
                 85                  90                  95
Ser Gly Leu Arg Val Ser Cys Leu Gly Leu Gly Thr Trp Val Thr Phe 
             100                105                110
Gly Gly Gln Ile Ser Asp Glu Val Ala Glu Arg Leu Met Thr Ile Ala 
         115                120                125
Tyr Glu Ser Gly Val Asn Leu Phe Asp Thr Ala Glu Val Tyr Ala Ala 
     130                135                140
Gly Lys Ala Glu Val Ile Leu Gly Ser Ile Ile Lys Lys Lys Gly Trp 
 145                150                155                160
Arg Arg Ser Ser Leu Val Ile Thr Thr Lys Leu Tyr Trp Gly Gly Lys 
                 165                170                175
Ala Glu Thr Glu Arg Gly Leu Ser Arg Lys His Ile Ile Glu Gly Leu 
             180                185                190
Lys Gly Ser Leu Gln Arg Leu Gln Leu Glu Tyr Val Asp Val Val Phe 
         195                200                205
Ala Asn Arg Pro Asp Ser Asn Thr Pro Met Glu Glu Ile Val Arg Ala 
     210                215                220
Met Thr His Val Ile Asn Gln Gly Met Ala Met Tyr Trp Gly Thr Ser 
 225                230                235                240
Arg Trp Ser Ala Met Glu Ile Met Glu Ala Tyr Ser Val Ala Arg Gln 
                 245                250                255
Phe Asn Met Ile Pro Pro Val Cys Glu Gln Ala Glu Tyr His Leu Phe 
             260                265                270
Gln Arg Glu Lys Val Glu Val Gln Leu Pro Glu Leu Tyr His Lys Ile 
         275                280                285
Gly Val Gly Ala Met Thr Trp Ser Pro Leu Ala Cys Gly Ile Ile Ser 
     290                295                300
Gly Lys Tyr Gly Asn Gly Val Pro Glu Ser Ser Arg Ala Ser Leu Lys 
 305                310                315                320
Cys Tyr Gln Trp Leu Lys Glu Arg Ile Val Ser Glu Glu Gly Arg Lys 
                 325                330                335
Gln Gln Asn Lys Leu Lys Asp Leu Ser Pro Ile Ala Glu Arg Leu Gly 
             340                345                350
Cys Thr Leu Pro Gln Leu Ala Val Ala Trp Cys Leu Arg Asn Glu Gly 
         355                360                365
Val Ser Ser Val Leu Leu Gly Ser Ser Thr Pro Glu Gln Leu Ile Glu 
     370                375                380
Asn Leu Gly Ala Ile Gln Val Leu Pro Lys Met Thr Ser His Val Val 
 385                390                395                400
Asn Glu Ile Asp Asn Ile Leu Arg Asn Lys Pro Tyr Ser Lys Lys Asp 
                 405                410                415
Tyr Arg Ser 
             420



<210> 9972
<211> 1339
<212> DNA
<213> Rattus norvegicus
<308> X70667
<400> 9972

cggctgtaa  tgtagcaac  ggtgttggg  ggggatgag  agagaccag  gagagagag  60
gtcagagcg  caggggatg  gacaggctg  tcagagtct  cactgattg  tggagacgc  120
aaggaaagt  ttttctatg  ctccaacct  cccctcctc  cccgtttct  tctggagaa  180
ctaaaatct  gactggaca  catccacaa  agaagcacc  agaagaaga  ttttttttc  240
cagcagctt  ctcaggacc  tgcaggagc  gcagccgga  ctggtcccg  cgataacca  300
gaactcttc  tgctgcccg  cctcctctt  tccgacgct  cctaacctc  cccagcacc  360
tgcagcccc  tctgccagc  accggagtg  cagtgggtt  tgcgagcag  ttttcatca  420
gccagaggt  ttcctggca  tgggcatcg  cagtctgat  gaaaacatc  tggtgatcc  480
ggctgtggt  aggaacggc  acctgcact  ccccatgta  ttcttcctg  tgagcctgc  540
gcaggccga  atgctggtg  gcctgtcca  ctccctgga  accatcatg  tcgtggtta  600
caacagcga  tccctgacc  tggaggacc  attcatcca  cacatggac  acatcttcg  660
ctctatgat  tgcatctcc  tggtggcct  catctgcaa  ctcctggcc  tcgccgtgg  720
caggtacgt  accatcttc  atgccctcc  ttaccacag  atcatgacg  ttaggaaag  780
cctctcctt  atcgtggcc  tctgggtct  ctgtggcat  tgcggcgtg  tgttcatcg  840
ctactccga  agcaagatg  tcatcgtgt  cctcatcac  atgttcttc  ccatggtgc  900
cctcatggg  accctgtac  tccacatgt  cctcttcgc  aggctgcac  tccagcgca  960
cgcggcact  ccacctgct  acggggtag  cccgcagca  cactcgtgc  tgaaggggg  1020
cgtcaccat  accatcctg  tgggggttt  catcttctg  tgggcgcct  tcttcctcc  1080
cctggtcct  atcatcacc  gccccacca  cccctactg  atctgctac  cggcgcact  1140
caacaccta  ctggttctc  tcatgtgca  ctctgtcat  gaccccctc  tctacgcct  1200
ccgcagcct  gagctgcgg  acaccttca  ggagattct  tgcggttgc  atggcatga  1260
cgtgggcta  gaacccccg  ggaggtgtt  cacggctag  caagagaga  aagcaatgc  1320
caggtgaga  acagaaggg  1339



<210> 9973
<211> 323
<212> PRT
<213> Rattus norvegicus
<308> CAA50005
<400> 9973

Met Asn Ser Ser Cys Cys Pro Ser Ser Ser Tyr Pro Thr Leu Pro Asn 
  1               5                  10                  15
Leu Ser Gln His Pro Ala Ala Pro Ser Ala Ser Asn Arg Ser Gly Ser 
             20                  25                  30
Gly Phe Cys Glu Gln Val Phe Ile Lys Pro Glu Val Phe Leu Ala Leu 
         35                  40                  45
Gly Ile Val Ser Leu Met Glu Asn Ile Leu Val Ile Leu Ala Val Val 
     50                  55                  60
Arg Asn Gly Asn Leu His Ser Pro Met Tyr Phe Phe Leu Leu Ser Leu 
 65                  70                  75                  80
Leu Gln Ala Asp Met Leu Val Ser Leu Ser Asn Ser Leu Glu Thr Ile 
                 85                  90                  95
Met Ile Val Val Ile Asn Ser Asp Ser Leu Thr Leu Glu Asp Gln Phe 
             100                105                110
Ile Gln His Met Asp Asn Ile Phe Asp Ser Met Ile Cys Ile Ser Leu 
         115                120                125
Val Ala Ser Ile Cys Asn Leu Leu Ala Ile Ala Val Asp Arg Tyr Val 
     130                135                140
Thr Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Met Thr Val Arg Lys 
 145                150                155                160
Ala Leu Ser Leu Ile Val Ala Ile Trp Val Cys Cys Gly Ile Cys Gly 
                 165                170                175
Val Met Phe Ile Val Tyr Ser Glu Ser Lys Met Val Ile Val Cys Leu 
             180                185                190
Ile Thr Met Phe Phe Ala Met Val Leu Leu Met Gly Thr Leu Tyr Ile 
         195                200                205
His Met Phe Leu Phe Ala Arg Leu His Val Gln Arg Ile Ala Ala Leu 
     210                215                220
Pro Pro Ala Asp Gly Val Ala Pro Gln Gln His Ser Cys Met Lys Gly 
 225                230                235                240
Ala Val Thr Ile Thr Ile Leu Leu Gly Val Phe Ile Phe Cys Trp Ala 
                 245                250                255
Pro Phe Phe Leu His Leu Val Leu Ile Ile Thr Cys Pro Thr Asn Pro 
             260                265                270
Tyr Cys Ile Cys Tyr Thr Ala His Phe Asn Thr Tyr Leu Val Leu Ile 
         275                280                285
Met Cys Asn Ser Val Ile Asp Pro Leu Ile Tyr Ala Phe Arg Ser Leu 
     290                295                300
Glu Leu Arg Asn Thr Phe Lys Glu Ile Leu Cys Gly Cys Asn Gly Met 
 305                310                315                320
Asn Val Gly 
                 325



<210> 9974
<211> 1083
<212> DNA
<213> Homo sapiens
<308> NM_019888
<400> 9974

atgagcatc  aaaagacgt  tctggaggg  gattttgtc  ttcctgtga  cagcagcag  60
ttcctacgg  ccctgctgg  gccccagct  ggatcagcc  ttctgacag  aatgaatgc  120
tcgtgctgc  tgccctctg  tcagccaac  ctgcctaat  gctcggagc  cctccaagc  180
cctttcttc  gcaaccaga  cagcagcgc  ttctgtgag  aggtcttca  caagcccga  240
gttttcctg  ctctgggca  cgtcagtct  ctggaaaac  tcctggtta  cctggccgt  300
gtcaggaac  gcaacctgc  ctccccgat  tacttcttt  tctgcagcc  ggcggtggc  360
gacatgctg  taagtgtgt  caatgccct  gagaccatc  tgatcgcca  cgtccacag  420
gactacctg  ccttcgagg  ccagtttat  cagcacatg  acaacatct  cgactccat  480
atctgcatc  ccctggtgg  ctccatctg  aacctcctg  ccatcgccg  cgacaggta  540
gtcaccatc  tttacgcgc  ccgctacca  agcatcatg  ccgtgagga  ggccctcac  600
ttgatcgtg  ccatctggg  ctgctgcgg  gtctgtggc  tggtgttca  cgtctactc  660
gagagcaaa  tggtcattg  gtgcctcat  accatgttc  tcgccatga  gctcctcat  720
ggcaccctc  acgtgcaca  gttcctctt  gcgcggctg  acgtcaagc  catagcagc  780
ctgccacct  ccgacgggg  ggccccaca  caacactca  gcatgaagg  ggcagtcac  840
atcaccatt  tcctgggcg  gttcatctt  tgctgggcc  ccttcttcc  ccacctggt  900
ctcatcatc  cctgcccca  caaccccta  tgcatctgc  acactgccc  cttcaacac  960
tacctggtc  tcatcatgt  caactccgt  atcgaccca  tcatctacg  tttccggag  1020
ctggaattg  gcaacacct  tagggagat  ctctgtggc  gcaacggca  gaacttggg  1080
tag  1083



<210> 9975
<211> 360
<212> PRT
<213> Homo sapiens
<308> NP_063941
<400> 9975

Met Ser Ile Gln Lys Thr Tyr Leu Glu Gly Asp Phe Val Phe Pro Val 
  1               5                  10                  15
Ser Ser Ser Ser Phe Leu Arg Thr Leu Leu Glu Pro Gln Leu Gly Ser 
             20                  25                  30
Ala Leu Leu Thr Ala Met Asn Ala Ser Cys Cys Leu Pro Ser Val Gln 
         35                  40                  45
Pro Thr Leu Pro Asn Gly Ser Glu His Leu Gln Ala Pro Phe Phe Ser 
     50                  55                  60
Asn Gln Ser Ser Ser Ala Phe Cys Glu Gln Val Phe Ile Lys Pro Glu 
 65                  70                  75                  80
Val Phe Leu Ser Leu Gly Ile Val Ser Leu Leu Glu Asn Ile Leu Val 
                 85                  90                  95
Ile Leu Ala Val Val Arg Asn Gly Asn Leu His Ser Pro Met Tyr Phe 
             100                105                110
Phe Leu Cys Ser Leu Ala Val Ala Asp Met Leu Val Ser Val Ser Asn 
         115                120                125
Ala Leu Glu Thr Ile Met Ile Ala Ile Val His Ser Asp Tyr Leu Thr 
     130                135                140
Phe Glu Asp Gln Phe Ile Gln His Met Asp Asn Ile Phe Asp Ser Met 
 145                150                155                160
Ile Cys Ile Ser Leu Val Ala Ser Ile Cys Asn Leu Leu Ala Ile Ala 
                 165                170                175
Val Asp Arg Tyr Val Thr Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile 
             180                185                190
Met Thr Val Arg Lys Ala Leu Thr Leu Ile Val Ala Ile Trp Val Cys 
         195                200                205
Cys Gly Val Cys Gly Val Val Phe Ile Val Tyr Ser Glu Ser Lys Met 
     210                215                220
Val Ile Val Cys Leu Ile Thr Met Phe Phe Ala Met Met Leu Leu Met 
 225                230                235                240
Gly Thr Leu Tyr Val His Met Phe Leu Phe Ala Arg Leu His Val Lys 
                 245                250                255
Arg Ile Ala Ala Leu Pro Pro Ala Asp Gly Val Ala Pro Gln Gln His 
             260                265                270
Ser Cys Met Lys Gly Ala Val Thr Ile Thr Ile Leu Leu Gly Val Phe 
         275                280                285
Ile Phe Cys Trp Ala Pro Phe Phe Leu His Leu Val Leu Ile Ile Thr 
     290                295                300
Cys Pro Thr Asn Pro Tyr Cys Ile Cys Tyr Thr Ala His Phe Asn Thr 
 305                310                315                320
Tyr Leu Val Leu Ile Met Cys Asn Ser Val Ile Asp Pro Leu Ile Tyr 
                 325                330                335
Ala Phe Arg Ser Leu Glu Leu Arg Asn Thr Phe Arg Glu Ile Leu Cys 
             340                345                350
Gly Cys Asn Gly Met Asn Leu Gly 
         355                360



<210> 9976
<211> 1959
<212> DNA
<213> Rattus norvegicus
<308> X70706
<400> 9976

ccacctata  tttattcca  ctctggcaa  ggactgcaa  ggcagccag  aaggagatt  60
atcttcaca  ggacgagat  gcaaccact  agatttcca  agatgagct  gatgaactc  120
aagaggcct  tgcaaaagt  gatctcaac  gcaatggat  catttgcga  tatgaactt  180
atgagcttt  caaggaagc  aatatgcca  tgcccggat  taaagtgag  gaaattatt  240
aaaaactca  gctggatgg  gacagaaat  aagatggga  gataagctt  aatgaattt  300
tttatattt  ccaagaggt  aagagcagt  acattgcta  aaccttccg  aaagccatc  360
acaggaaag  agggatttg  gctctggga  gaacttcag  gttgtccag  gaaggaacc  420
agcattcct  ctcagagga  gaaaaatat  ctttcgtta  ttggataaa  aaagctttg  480
aaaatgatc  cgattgcag  catgtcata  ccatgaacc  aaatactga  gacctattc  540
aagcagttg  tgatggaat  gtgctctgc  aaatgatca  cctttctgt  cccgataca  600
ttgatgaga  agcaatcaa  aagaagaag  ttacaccct  catcattca  gaaaacttg  660
acttggccc  gaattctgc  tctgccatt  gatgtcacg  tgtgaacat  ggtgccgaa  720
atctgcgtg  cgggaaacc  catctggtc  tgggactgc  ctggcagat  attaagatt  780
gcttatttg  tgacattga  ttaagcagg  atgaagcac  ggcggcttt  cttcgagat  840
gtgagactc  ggaggagct  atgaaattg  ctccagaag  gcttctgct  agatgggcc  900
acttccatc  ggaaaactc  ggctggcaa  agatcaaca  cttcagtgc  gacatcaag  960
attccaaag  ctatttcca  ctactcaat  aaattgcac  gaaaggaca  aaggaaggg  1020
aaccacgga  agatattaa  atgtcaggt  tcaacgaaa  agatgattt  aagagagcc  1080
aaagtatgc  tcagcaagc  gataaatta  gctgcagac  gttcgttac  ccggctgat  1140
ttgtgagcg  aaaccccaa  ctgaacttg  cctttgtag  caacctctt  aataaatat  1200
cagcactaa  taaacctga  aaccaggat  ttgattgga  tcttctaga  ggagaaact  1260
gtgaagaaa  aacctttcg  aactggatg  actctcttg  tgtgaatcc  catgtcaac  1320
atctctatg  tgacctgca  gatgccctg  tgatcttac  gctgtatga  agaattaaa  1380
ttcctgtgg  ctggagtaa  gttaacaag  ctccatacc  aaagctggg  gccaacatg  1440
aaaagttag  aaactgcaa  tatgcagtt  aattaggga  gaatcaggc  aaattctcc  1500
tggttggca  tggaggaca  gacttgaat  atgggaacc  aaccttgac  ttggctgta  1560
tctggcagc  gatgagaag  tataccctt  atgttatgg  agatcttgg  gagggtcag  1620
aagcaactg  tgacatcat  gtaaactgg  tcaatggaa  attgagtga  gctggaaag  1680
caacttcta  tcagagttt  aaggacaag  cgatcagct  cagtttggc  gttgtggat  1740
taattgatg  catccagcc  ggctgcatt  actatgacc  tgtgaagac  ggaaatcta  1800
cagaagaag  caagcacaa  aacgccaag  atgcagtgt  gatggctag  agaatagga  1860
ccagagtgt  tgctctccc  gaagacctt  tggaagtaa  accgaagat  gtcatgacc  1920
tgtttgcct  tttgatggg  aggggaatg  agagtgtaa  1959



<210> 9977
<211> 627
<212> PRT
<213> Rattus norvegicus
<308> Q63598
<400> 9977

Met Ala Thr Thr Gln Ile Ser Lys Asp Glu Leu Asp Glu Leu Lys Glu 
  1               5                  10                  15
Ala Phe Ala Lys Val Asp Leu Asn Ser Asn Gly Phe Ile Cys Asp Tyr 
             20                  25                  30
Glu Leu His Glu Leu Phe Lys Glu Ala Asn Met Pro Leu Pro Gly Tyr 
         35                  40                  45
Lys Val Arg Glu Ile Ile Gln Lys Leu Met Leu Asp Gly Asp Arg Asn 
     50                  55                  60
Lys Asp Gly Lys Ile Ser Phe Asn Glu Phe Val Tyr Ile Phe Gln Glu 
 65                  70                  75                  80
Val Lys Ser Ser Asp Ile Ala Lys Thr Phe Arg Lys Ala Ile Asn Arg 
                 85                  90                  95
Lys Glu Gly Ile Cys Ala Leu Gly Gly Thr Ser Glu Leu Ser Ser Glu 
             100                105                110
Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
         115                120                125
Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
     130                135                140
Pro Met Asn Pro Asn Thr Asp Asp Leu Phe Lys Ala Val Gly Asp Gly 
 145                150                155                160
Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                 165                170                175
Glu Arg Ala Ile Asn Lys Lys Lys Leu Thr Pro Phe Ile Ile Gln Glu 
             180                185                190
Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
         195                200                205
Val Asn Ile Gly Ala Glu Asp Leu Arg Ala Gly Lys Pro His Leu Val 
     210                215                220
Leu Gly Leu Leu Trp Gln Ile Ile Lys Ile Gly Leu Phe Ala Asp Ile 
 225                230                235                240
Glu Leu Ser Arg Asn Glu Ala Leu Ala Ala Leu Leu Arg Asp Gly Glu 
                 245                250                255
Thr Leu Glu Glu Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
             260                265                270
Trp Ala Asn Phe His Leu Glu Asn Ser Gly Trp Gln Lys Ile Asn Asn 
         275                280                285
Phe Ser Ala Asp Ile Lys Asp Ser Lys Ala Tyr Phe His Leu Leu Asn 
     290                295                300
Gln Ile Ala Pro Lys Gly Gln Lys Glu Gly Glu Pro Arg Ile Asp Ile 
 305                310                315                320
Asn Met Ser Gly Phe Asn Glu Thr Asp Asp Leu Lys Arg Ala Glu Ser 
                 325                330                335
Met Leu Gln Gln Ala Asp Lys Leu Gly Cys Arg Gln Phe Val Thr Pro 
             340                345                350
Ala Asp Val Val Ser Gly Asn Pro Lys Leu Asn Leu Ala Phe Val Ala 
         355                360                365
Asn Leu Phe Asn Lys Tyr Pro Ala Leu Thr Lys Pro Glu Asn Gln Asp 
     370                375                380
Ile Asp Trp Thr Leu Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
 385                390                395                400
Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro His Val Asn His Leu 
                 405                410                415
Tyr Val Asp Leu Gln Asp Ala Leu Val Ile Leu Gln Leu Tyr Glu Arg 
             420                425                430
Ile Lys Val Pro Val Asp Trp Ser Lys Val Asn Lys Pro Pro Tyr Pro 
         435                440                445
Lys Leu Gly Ala Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
     450                455                460
Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
 465                470                475                480
Gln Asp Leu Asn Asp Gly Asn Pro Thr Leu Thr Leu Ala Val Val Trp 
                 485                490                495
Gln Leu Met Arg Arg Tyr Thr Leu Asn Val Met Glu Asp Leu Gly Glu 
             500                505                510
Gly Gln Lys Ala Thr Asp Asp Ile Ile Val Asn Trp Val Asn Gly Thr 
         515                520                525
Leu Ser Glu Ala Gly Lys Ser Thr Ser Ile Gln Ser Phe Lys Asp Lys 
     530                535                540
Thr Ile Ser Ser Ser Leu Ala Val Val Asp Leu Ile Asp Ala Ile Gln 
 545                550                555                560
Pro Gly Cys Ile Asn Tyr Asp Leu Val Lys Thr Gly Asn Leu Thr Glu 
                 565                570                575
Glu Asp Lys His Asn Asn Ala Lys Tyr Ala Val Ser Met Ala Arg Arg 
             580                585                590
Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Lys 
         595                600                605
Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Arg Gly Met 
     610                615                620
Lys Ser Val 
 625



<210> 9978
<211> 3089
<212> DNA
<213> Homo sapiens
<308> NM_005032
<400> 9978

aaagattcc  aggtgcaga  gttgtctga  tgggttggt  ggcggcagt  gggccagac  60
caggactct  cgactttac  tctttaaat  gatgagatg  ctaccactc  gatttccaa  120
gatgagctt  atgaactca  agaggcctt  gcaaaagtt  atctcaaca  caacggatt  180
atttgtgac  atgaacttc  tgagctctt  aaggaagct  atatgccat  accaggata  240
aaagtgaga  aaattattc  gaaactcat  ctggatggt  acaggaata  agatgggaa  300
ataagtttt  acgaatttg  ttatatttt  caagaggta  aaagtagtg  tattgccaa  360
accttccgc  aagcaatca  caggaaaga  ggtatttgt  ctctgggtg  aacttcaga  420
ttgtccagc  aaggaacac  gcattctta  tcagaggaa  aaaaatatg  ttttgttaa  480
tggataaac  aagctttgg  aaatgatcc  gattgtaga  atgttatac  aatgaaccc  540
aacaccgat  acctgttca  agctgttgg  gatggaatt  tgctttgta  aatgattaa  600
ctttcagtt  ctgatacca  tgatgaaag  gcaatcaac  agaagaaac  tacaccctt  660
atcattcag  aaaacttga  cttggcact  aactctgct  ctgccattg  gtgtcatgt  720
gtgaacatt  gtgcagaag  tttgagggc  gggaaacct  atctggttt  gggactgct  780
tggcagatc  ttaagatcg  tttgttcgc  gacattgaa  taagcagga  tgaagcctt  840
gctgcttta  tccgagatg  tgagacttt  gaggaactt  tgaaattgt  tccagaaga  900
cttctgctt  gatgggcaa  ctttcattt  gaaaactcg  gctggcaaa  aattaacaa  960
tttagtgct  acatcaagg  ttccaaagc  tatttccat  ttctcaatc  aatcgcacc  1020
aaaggacaa  aggaaggtg  accacggat  gatattaac  tgtcaggtt  caatgaaac  1080
gatgatttg  agagagctg  gagtatgct  caacaagca  ataaattag  ttgcagaca  1140
tttgttacc  ctgctgatg  tgtcagtgg  aaccccaaa  tcaacttag  tttcgtggc  1200
aacctgttt  ataaatacc  agcactaac  aagccagag  accaggata  tgactggac  1260
ctattagaa  gagaaactc  tgaagaaag  accttccgt  actggatga  ctctcttgg  1320
gtcaatcct  acgtaaacc  tctctatgc  gacctgcaa  atgccctgg  aatcttaca  1380
ttatatgaa  gaattaaag  tcctgttga  tggagtaag  ttaataaac  tccataccc  1440
aaactggga  ccaacatga  aaagctaga  aactgcaac  atgctgttg  attagggaa  1500
catcctgct  aattctccc  ggttggcat  ggagggcaa  acctgaatg  tgggaacca  1560
accctgact  tagctttag  ctggcagct  atgagaaga  ataccctca  tgtcctgga  1620
gatcttgga  atggtcaga  agccaatga  gacatcatt  tgaactggg  gaacagaac  1680
ttgagtgaa  ctggaaaat  aacttccat  cagagtttt  aggacaaga  gatcagctc  1740
agtttggca  ttgtggatt  aattgatgc  atccagcca  gctgtataa  ctatgacct  1800
gtgaagagt  gcaatctaa  agaagatga  aagcacaat  atgccaagt  tgcagtgtc  1860
atggctaga  gaatcggag  cagagtgta  gctctccct  aagaccttg  ggaagtaaa  1920
cccaagatg  tcatgactg  gtttgcatg  ttgatgggc  ggggaatga  gagagtgta  1980
aataaccaa  ctgaataaa  cagccatgc  cccaggtgc  tgattcgca  gtcagctat  2040
tcccaggtg  agtgcttat  gcttaagga  ctcttggcc  ttcaaagga  ttttcattt  2100
gattaacag  actagctta  catgagagc  tcaggggaa  gggtttaag  aaaacaact  2160
ctctttccc  tagtcagag  tgaatttgt  aggcacgcc  gaaatgtgc  catagccaa  2220
acattttac  ctctcctcc  agaatgctg  ccttgacat  tcccattgc  gtatgttat  2280
tcttgctct  ttatctttt  ccctcttag  atgtccctc  cttgggact  gcttagatg  2340
tgggatatg  atattatta  acagtaatt  tgctttcca  ccagtatgc  agttcttat  2400
cgagaacta  ggtcagagc  tatttggat  tgagtatcc  ttgcttatc  ttgtagtac  2460
gaaaatttg  cgaagtaac  ggctgtgca  aatgtaata  aagcttttc  tattctttt  2520
ttcttaagt  cagtatctt  ttacagtat  ctttctaca  gatcctttt  tgtacattt  2580
agaatattt  gattatatt  aacaagact  ctgattttg  tactttttt  aaggggtct  2640
caagtaagt  aaacataca  cgtagctag  agaaaaatg  accttaaat  tgcatcttc  2700
ctctcatac  caagctgta  acaattgaa  tattttgtc  taaatcact  ggttcaata  2760
atgcttatt  gttttaaaa  ctgtatcat  aaactctct  tctaaattt  aaatgctgt  2820
gaatatgat  cttttgagg  gagagtgtg  tcagaactt  gacgggatt  ggtaggcca  2880
gtatgctaa  tgtacaata  attttttaa  tttacacct  aaacaaaga  atgtggtca  2940
taaaaataa  agtatatat  taggaatta  tgtactctt  ctttgtcaa  ctgtttgct  3000
tagtttcca  ggtattatg  tactctaac  ctgaaaagt  atgtaatct  gtagcaatg  3060
agtagttca  ataaaggca  ttacataat  3089



<210> 9979
<211> 627
<212> PRT
<213> Homo sapiens
<308> P13797
<400> 9979

Met Ala Thr Thr Gln Ile Ser Lys Asp Glu Leu Asp Glu Leu Lys Glu 
  1               5                  10                  15
Ala Phe Ala Lys Val Asp Leu Asn Ser Asn Gly Phe Ile Cys Asp Tyr 
             20                  25                  30
Glu Leu His Glu Leu Phe Lys Glu Ala Asn Met Pro Leu Pro Gly Tyr 
         35                  40                  45
Lys Val Arg Glu Ile Ile Gln Lys Leu Met Leu Asp Gly Asp Arg Asn 
     50                  55                  60
Lys Asp Gly Lys Ile Ser Phe Asp Glu Phe Val Tyr Ile Phe Gln Glu 
 65                  70                  75                  80
Val Lys Ser Ser Asp Ile Ala Lys Thr Phe Arg Lys Ala Ile Asn Arg 
                 85                  90                  95
Lys Glu Gly Ile Cys Ala Leu Gly Gly Thr Ser Glu Leu Ser Ser Glu 
             100                105                110
Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
         115                120                125
Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
     130                135                140
Pro Met Asn Pro Asn Thr Asp Asp Leu Phe Lys Ala Val Gly Asp Gly 
 145                150                155                160
Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                 165                170                175
Glu Arg Ala Ile Asn Lys Lys Lys Leu Thr Pro Phe Ile Ile Gln Glu 
             180                185                190
Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
         195                200                205
Val Asn Ile Gly Ala Glu Asp Leu Arg Ala Gly Lys Pro His Leu Val 
     210                215                220
Leu Gly Leu Leu Trp Gln Ile Ile Lys Ile Gly Leu Phe Ala Asp Ile 
 225                230                235                240
Glu Leu Ser Arg Asn Glu Ala Leu Ala Ala Leu Leu Arg Asp Gly Glu 
                 245                250                255
Thr Leu Glu Glu Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
             260                265                270
Trp Ala Asn Phe His Leu Glu Asn Ser Gly Trp Gln Lys Ile Asn Asn 
         275                280                285
Phe Ser Ala Asp Ile Lys Asp Ser Lys Ala Tyr Phe His Leu Leu Asn 
     290                295                300
Gln Ile Ala Pro Lys Gly Gln Lys Glu Gly Glu Pro Arg Ile Asp Ile 
 305                310                315                320
Asn Met Ser Gly Phe Asn Glu Thr Asp Asp Leu Lys Arg Ala Glu Ser 
                 325                330                335
Met Leu Gln Gln Ala Asp Lys Leu Gly Cys Arg Gln Phe Val Thr Pro 
             340                345                350
Ala Asp Val Val Ser Gly Asn Pro Lys Leu Asn Leu Ala Phe Val Ala 
         355                360                365
Asn Leu Phe Asn Lys Tyr Pro Ala Leu Thr Lys Pro Glu Asn Gln Asp 
     370                375                380
Ile Asp Trp Thr Leu Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
 385                390                395                400
Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro His Val Asn His Leu 
                 405                410                415
Tyr Ala Asp Leu Gln Asp Ala Leu Val Ile Leu Gln Leu Tyr Glu Arg 
             420                425                430
Ile Lys Val Pro Val Asp Trp Ser Lys Val Asn Lys Pro Pro Tyr Pro 
         435                440                445
Lys Leu Gly Ala Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
     450                455                460
Glu Leu Gly Lys His Pro Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
 465                470                475                480
Gln Asp Leu Asn Asp Gly Asn Gln Thr Leu Thr Leu Ala Leu Val Trp 
                 485                490                495
Gln Leu Met Arg Arg Tyr Thr Leu Asn Val Leu Glu Asp Leu Gly Asp 
             500                505                510
Gly Gln Lys Ala Asn Asp Asp Ile Ile Val Asn Trp Val Asn Arg Thr 
         515                520                525
Leu Ser Glu Ala Gly Lys Ser Thr Ser Ile Gln Ser Phe Lys Asp Lys 
     530                535                540
Thr Ile Ser Ser Ser Leu Ala Val Val Asp Leu Ile Asp Ala Ile Gln 
 545                550                555                560
Pro Gly Cys Ile Asn Tyr Asp Leu Val Lys Ser Gly Asn Leu Thr Glu 
                 565                570                575
Asp Asp Lys His Asn Asn Ala Lys Tyr Ala Val Ser Met Ala Arg Arg 
             580                585                590
Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Lys 
         595                600                605
Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Arg Gly Met 
     610                615                620
Lys Arg Val 
 625



<210> 9980
<211> 1136
<212> DNA
<213> Rattus norvegicus
<308> X71127
<400> 9980

gggcttctt  gacgttttt  ggaggggac  gcaagggaa  gtccttctg  ctctaggga  60
ccagacttc  gctttctgc  gacagcagc  ggctctggg  tctgggaat  cactgctgt  120
tggcctaga  gcatcatag  acacgagga  tccatacac  ggaggcccc  gaagctgag  180
tgagctgat  aagacacag  ggagtgaga  cttgacacc  ctgttgctg  tgctcctgg  240
tttgctcca  gtctcctgg  cccaaagca  ctgtactgg  tcccctggc  tccctgggg  300
ccctggcat  cctggggtc  ctggctctg  tggcaaacc  ggcactcca  ggataaaag  360
agagaaagg  ctccccgga  tggctggag  ccatggtga  ttaggagag  aaggggatg  420
agggatccc  gggatccca  gcaaagttg  ccccaaggg  cccgtcggc  ctaagggtg  480
tccaggccc  cctggaccc  gcggtccca  aggtggctc  ggagactac  aggctaccc  540
gaaagtagc  ttctctgcc  tgaggacgg  caacagcgc  ctgcgacca  accaggcca  600
tcgcttcga  aaggtgatc  ccaatgtta  tgataacta  gagccgcgc  gtggcaagt  660
cacctgcaa  gtacctggc  tctactact  cacctacca  gccagttcc  gcgggaatc  720
gtgtgtgaa  atcgtgcgc  gccgcgacc  agaccgcat  cagaaagtt  tcaccttct  780
cgactatgc  caaaacacc  tccaggtca  cacgggtgg  gtagtcttg  agctggagc  840
ggaagaggt  gttcacctg  aggccacag  caagaactc  ctgctgggc  tcgagggag  900
caatagcat  ttcactggc  ttctgcttt  ccctgacat  gatgtatga  cacggggtc  960
aatcactcc  atccaaaac  tcctccctg  cagtaatcc  ccctggacc  cagacactg  1020
cctttgact  cccaaagcc  tgaccagag  cctgtagat  ttacagaat  ggtaaataa  1080
ctcttcaag  ccaagaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaccc  1136



<210> 9981
<211> 253
<212> PRT
<213> Rattus norvegicus
<308> P31721
<400> 9981

Met Lys Thr Gln Trp Ser Glu Ile Leu Thr Pro Leu Leu Leu Leu Leu 
  1               5                  10                  15
Leu Gly Leu Leu His Val Ser Trp Ala Gln Ser Ser Cys Thr Gly Ser 
             20                  25                  30
Pro Gly Ile Pro Gly Val Pro Gly Ile Pro Gly Val Pro Gly Ser Asp 
         35                  40                  45
Gly Lys Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu Pro Gly 
     50                  55                  60
Leu Ala Gly Asp His Gly Glu Leu Gly Glu Lys Gly Asp Ala Gly Ile 
 65                  70                  75                  80
Pro Gly Ile Pro Gly Lys Val Gly Pro Lys Gly Pro Val Gly Pro Lys 
                 85                  90                  95
Gly Ala Pro Gly Pro Pro Gly Pro Arg Gly Pro Lys Gly Gly Ser Gly 
             100                105                110
Asp Tyr Lys Ala Thr Gln Lys Val Ala Phe Ser Ala Leu Arg Thr Val 
         115                120                125
Asn Ser Ala Leu Arg Pro Asn Gln Ala Ile Arg Phe Glu Lys Val Ile 
     130                135                140
Thr Asn Val Asn Asp Asn Tyr Glu Pro Arg Ser Gly Lys Phe Thr Cys 
 145                150                155                160
Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser Arg Gly 
                 165                170                175
Asn Leu Cys Val Asn Ile Val Arg Gly Arg Asp Arg Asp Arg Met Gln 
             180                185                190
Lys Val Leu Thr Phe Cys Asp Tyr Ala Gln Asn Thr Phe Gln Val Thr 
         195                200                205
Thr Gly Gly Val Val Leu Lys Leu Glu Gln Glu Glu Val Val His Leu 
     210                215                220
Gln Ala Thr Asp Lys Asn Ser Leu Leu Gly Val Glu Gly Ala Asn Ser 
 225                230                235                240
Ile Phe Thr Gly Phe Leu Leu Phe Pro Asp Met Asp Val 
                 245                250



<210> 9982
<211> 935
<212> DNA
<213> Homo sapiens
<308> X03084
<400> 9982

ccaggccca  ctcagctgc  ccgggcccc  agccatccc  ggcatcccg  gtatccctg  60
gacacctgg  cccgatggc  aacctggga  cccagggat  aaaggagag  aagggcttc  120
agggctggc  ggagaccat  gtgagttcg  agagaaggg  gacccaggg  ttcctggga  180
tccaggaaa  gtcggcccc  agggcccca  gggccctaa  ggtggccca  gggcccctg  240
agccccagg  cccaaaggt  aatcgggag  ctacaaggc  acccagaaa  tcgccttct  300
tgccacaag  accatcaac  tccccctgc  ccgggacca  accatccgc  tcgaccacg  360
gatcaccaa  atgaacaac  attatgagc  ccgcagtgg  aagttcacc  gcaaggtgc  420
cggtctcta  tacttcacc  accacgcca  ctctcgagg  aacctgtgc  tgaacctca  480
gcgtggccg  gagcgtgca  agaaggtgg  caccttctg  gactatgcc  acaacacct  540
ccaggtcac  accggtggc  tggtcctca  gctggagca  ggggagaac  tcttcctgc  600
ggccaccga  aagaactca  tactgggca  ggagggtgc  aacagcatc  tttccgggt  660
cctgctctt  ccagatatg  aggcctgac  tgtgggctg  ttcacatcc  ccccggctc  720
ccctgccag  aacgctcac  ctaccccca  caccacccc  tgcccagcc  atggacaca  780
tagggcttg  tgaatgctg  tgagtgaat  agtaaataa  ctcttcaag  ccaaggaac  840
gtggtctaa  tcaactctg  gtcccagca  tggcacacc  gaagtgcca  gctcagaaa  900
gttggttac  tgaatgaat  aaccatgaa  gaatg  935



<210> 9983
<211> 251
<212> PRT
<213> Homo sapiens
<308> P02746
<400> 9983

Met Lys Ile Pro Trp Gly Ser Ile Pro Val Leu Met Leu Leu Leu Leu 
  1               5                  10                  15
Leu Gly Leu Ile Asp Ile Ser Gln Ala Gln Leu Ser Cys Thr Gly Pro 
             20                  25                  30
Pro Ala Ile Pro Gly Ile Pro Gly Ile Pro Gly Thr Pro Gly Pro Asp 
         35                  40                  45
Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu Pro Gly 
     50                  55                  60
Leu Ala Gly Asp His Gly Glu Phe Gly Glu Lys Gly Asp Pro Gly Ile 
 65                  70                  75                  80
Pro Gly Asn Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly Pro Lys 
                 85                  90                  95
Gly Gly Pro Gly Ala Pro Gly Ala Pro Gly Pro Lys Gly Glu Ser Gly 
             100                105                110
Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg Thr Ile 
         115                120                125
Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His Val Ile 
     130                135                140
Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe Thr Cys 
 145                150                155                160
Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser Arg Gly 
                 165                170                175
Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln Lys Val 
             180                185                190
Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr Thr Gly 
         195                200                205
Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala 
     210                215                220
Thr Asp Lys Asn Ser Leu Leu Gly Met Glu Gly Ala Asn Ser Ile Phe 
 225                230                235                240
Ser Gly Phe Leu Leu Phe Pro Asp Met Glu Ala 
                 245                250



<210> 9984
<211> 1136
<212> DNA
<213> Rattus norvegicus
<308> X71127
<400> 9984

gggcttctt  gacgttttt  ggaggggac  gcaagggaa  gtccttctg  ctctaggga  60
ccagacttc  gctttctgc  gacagcagc  ggctctggg  tctgggaat  cactgctgt  120
tggcctaga  gcatcatag  acacgagga  tccatacac  ggaggcccc  gaagctgag  180
tgagctgat  aagacacag  ggagtgaga  cttgacacc  ctgttgctg  tgctcctgg  240
tttgctcca  gtctcctgg  cccaaagca  ctgtactgg  tcccctggc  tccctgggg  300
ccctggcat  cctggggtc  ctggctctg  tggcaaacc  ggcactcca  ggataaaag  360
agagaaagg  ctccccgga  tggctggag  ccatggtga  ttaggagag  aaggggatg  420
agggatccc  gggatccca  gcaaagttg  ccccaaggg  cccgtcggc  ctaagggtg  480
tccaggccc  cctggaccc  gcggtccca  aggtggctc  ggagactac  aggctaccc  540
gaaagtagc  ttctctgcc  tgaggacgg  caacagcgc  ctgcgacca  accaggcca  600
tcgcttcga  aaggtgatc  ccaatgtta  tgataacta  gagccgcgc  gtggcaagt  660
cacctgcaa  gtacctggc  tctactact  cacctacca  gccagttcc  gcgggaatc  720
gtgtgtgaa  atcgtgcgc  gccgcgacc  agaccgcat  cagaaagtt  tcaccttct  780
cgactatgc  caaaacacc  tccaggtca  cacgggtgg  gtagtcttg  agctggagc  840
ggaagaggt  gttcacctg  aggccacag  caagaactc  ctgctgggc  tcgagggag  900
caatagcat  ttcactggc  ttctgcttt  ccctgacat  gatgtatga  cacggggtc  960
aatcactcc  atccaaaac  tcctccctg  cagtaatcc  ccctggacc  cagacactg  1020
cctttgact  cccaaagcc  tgaccagag  cctgtagat  ttacagaat  ggtaaataa  1080
ctcttcaag  ccaagaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaccc  1136



<210> 9985
<211> 253
<212> PRT
<213> Rattus norvegicus
<308> P31721
<400> 9985

Met Lys Thr Gln Trp Ser Glu Ile Leu Thr Pro Leu Leu Leu Leu Leu 
  1               5                  10                  15
Leu Gly Leu Leu His Val Ser Trp Ala Gln Ser Ser Cys Thr Gly Ser 
             20                  25                  30
Pro Gly Ile Pro Gly Val Pro Gly Ile Pro Gly Val Pro Gly Ser Asp 
         35                  40                  45
Gly Lys Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu Pro Gly 
     50                  55                  60
Leu Ala Gly Asp His Gly Glu Leu Gly Glu Lys Gly Asp Ala Gly Ile 
 65                  70                  75                  80
Pro Gly Ile Pro Gly Lys Val Gly Pro Lys Gly Pro Val Gly Pro Lys 
                 85                  90                  95
Gly Ala Pro Gly Pro Pro Gly Pro Arg Gly Pro Lys Gly Gly Ser Gly 
             100                105                110
Asp Tyr Lys Ala Thr Gln Lys Val Ala Phe Ser Ala Leu Arg Thr Val 
         115                120                125
Asn Ser Ala Leu Arg Pro Asn Gln Ala Ile Arg Phe Glu Lys Val Ile 
     130                135                140
Thr Asn Val Asn Asp Asn Tyr Glu Pro Arg Ser Gly Lys Phe Thr Cys 
 145                150                155                160
Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser Arg Gly 
                 165                170                175
Asn Leu Cys Val Asn Ile Val Arg Gly Arg Asp Arg Asp Arg Met Gln 
             180                185                190
Lys Val Leu Thr Phe Cys Asp Tyr Ala Gln Asn Thr Phe Gln Val Thr 
         195                200                205
Thr Gly Gly Val Val Leu Lys Leu Glu Gln Glu Glu Val Val His Leu 
     210                215                220
Gln Ala Thr Asp Lys Asn Ser Leu Leu Gly Val Glu Gly Ala Asn Ser 
 225                230                235                240
Ile Phe Thr Gly Phe Leu Leu Phe Pro Asp Met Asp Val 
                 245                250



<210> 9986
<211> 935
<212> DNA
<213> Homo sapiens
<308> X03084
<400> 9986

ccaggccca  ctcagctgc  ccgggcccc  agccatccc  ggcatcccg  gtatccctg  60
gacacctgg  cccgatggc  aacctggga  cccagggat  aaaggagag  aagggcttc  120
agggctggc  ggagaccat  gtgagttcg  agagaaggg  gacccaggg  ttcctggga  180
tccaggaaa  gtcggcccc  agggcccca  gggccctaa  ggtggccca  gggcccctg  240
agccccagg  cccaaaggt  aatcgggag  ctacaaggc  acccagaaa  tcgccttct  300
tgccacaag  accatcaac  tccccctgc  ccgggacca  accatccgc  tcgaccacg  360
gatcaccaa  atgaacaac  attatgagc  ccgcagtgg  aagttcacc  gcaaggtgc  420
cggtctcta  tacttcacc  accacgcca  ctctcgagg  aacctgtgc  tgaacctca  480
gcgtggccg  gagcgtgca  agaaggtgg  caccttctg  gactatgcc  acaacacct  540
ccaggtcac  accggtggc  tggtcctca  gctggagca  ggggagaac  tcttcctgc  600
ggccaccga  aagaactca  tactgggca  ggagggtgc  aacagcatc  tttccgggt  660
cctgctctt  ccagatatg  aggcctgac  tgtgggctg  ttcacatcc  ccccggctc  720
ccctgccag  aacgctcac  ctaccccca  caccacccc  tgcccagcc  atggacaca  780
tagggcttg  tgaatgctg  tgagtgaat  agtaaataa  ctcttcaag  ccaaggaac  840
gtggtctaa  tcaactctg  gtcccagca  tggcacacc  gaagtgcca  gctcagaaa  900
gttggttac  tgaatgaat  aaccatgaa  gaatg  935



<210> 9987
<211> 251
<212> PRT
<213> Homo sapiens
<308> P02746
<400> 9987

Met Lys Ile Pro Trp Gly Ser Ile Pro Val Leu Met Leu Leu Leu Leu 
  1               5                  10                  15
Leu Gly Leu Ile Asp Ile Ser Gln Ala Gln Leu Ser Cys Thr Gly Pro 
             20                  25                  30
Pro Ala Ile Pro Gly Ile Pro Gly Ile Pro Gly Thr Pro Gly Pro Asp 
         35                  40                  45
Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu Pro Gly 
     50                  55                  60
Leu Ala Gly Asp His Gly Glu Phe Gly Glu Lys Gly Asp Pro Gly Ile 
 65                  70                  75                  80
Pro Gly Asn Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly Pro Lys 
                 85                  90                  95
Gly Gly Pro Gly Ala Pro Gly Ala Pro Gly Pro Lys Gly Glu Ser Gly 
             100                105                110
Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg Thr Ile 
         115                120                125
Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His Val Ile 
     130                135                140
Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe Thr Cys 
 145                150                155                160
Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser Arg Gly 
                 165                170                175
Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln Lys Val 
             180                185                190
Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr Thr Gly 
         195                200                205
Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala 
     210                215                220
Thr Asp Lys Asn Ser Leu Leu Gly Met Glu Gly Ala Asn Ser Ile Phe 
 225                230                235                240
Ser Gly Phe Leu Leu Phe Pro Asp Met Glu Ala 
                 245                250



<210> 9988
<211> 4447
<212> DNA
<213> Rattus norvegicus
<308> X72757
<400> 9988

gatccacct  cctctgctt  ctgagtgct  gtattaaag  tgtgtgcca  caccatcca  60
caatacacc  gtttttttt  tttaattgt  catatagtt  agtatggcc  tgaactcat  120
aagcatgag  ctgctgcct  tacctcctt  tgttatttt  agatagggt  tcataccat  180
gacaaggct  atcacagac  ctatatgtg  tccagagtg  cctctaatt  gagattccc  240
cctcggtct  tcagaactg  gccatatac  catacattt  aacttgggg  tgtgtgggt  300
gagacaggg  ttcacttta  agcccaggc  agtctctaa  tcacaacaa  cctcctgac  360
catctcact  ttgctggga  tatgagcca  ctgccacca  gcttcccgt  ttgtgttgt  420
tttgtttca  ggagaaggg  ctcactatg  agcccctgg  cagcctgga  ctctcggta  480
aagaaagag  ctatcctgg  atcagtcca  cgtcttcct  caagatgcc  ccacacctg  540
cattccagc  tttttaaaa  aaaaaactt  tatctttaa  aaggcgttt  gacaaaaag  600
aagaaaaaa  aaagcagat  tttaaaaag  tctacagac  aaatttaac  gatctttgt  660
gaattcgag  gagagagca  gaccattgg  caatcgctg  ggatatgga  ctgaaacaa  720
gtccagatt  tctggcacc  attccaggg  tctttctgg  tccaggagc  attcattga  780
tcattaatt  atggattca  aattcatat  ttcattaaa  tgcataaag  acctgctac  840
tgatttcgg  taactctgg  aatgcagcg  tggcaaaat  taagcacca  ggactttac  900
gtccatata  ggcgtcaca  aagagaata  caacggtct  taagagtga  gacaagggt  960
tcgggtgcc  tggaaatcg  ggaattaga  gtcagcgag  aaaggagaa  ggcgcttcc  1020
ataacgtca  ttgttctcg  catttcaga  cctgtccag  gactccaaa  aaggtagca  1080
ttaaaaaca  aacaaaaaa  tatctcaca  aagctctat  cagcgaaca  cctcaccca  1140
cagcagagg  gggaggtgg  gcacaggta  gaaacgcat  cgcaatctc  ctcgtgccg  1200
cccgagggt  tggaccagg  ccgaaaatg  gcgcaggcg  tacaattcc  ggccagtga  1260
aaggcgttg  ccaatgaaa  ttcgtttgg  gtctctgtc  cgccccctt  gggaccccc  1320
tttccgctt  cggcgcgcc  ggtagttcc  agatggcgt  ggcggtgct  agtgcgtct  1380
gagtctctg  gctgctggg  cgggccctc  cacgggtgg  gcggcccat  tcgagtggc  1440
cccacggcg  ggagggttc  ggtaccggg  ctcgggtgg  cgtgggggc  tcagtggct  1500
gcacgcggc  tggcggggc  gtgaccttg  cgggaggcc  tgcgggagg  agcggccga  1560
gctgacatt  tggtccccg  tgcagctcg  atttggaag  ccctcacct  cttcgtggc  1620
ctgcccggg  tgggagtga  catgctcaa  gttttcctg  agtcgcgac  cgaagagca  1680
gagagaccc  agttcgtcg  ctaccccca  ctccgcatc  ggactaagg  acgcgctgc  1740
cctctgctg  ccttcaagc  tccgttatt  ctgggttgt  cactcccca  tcccagccc  1800
tggtgcgct  ggatctcgg  tgcctgtct  tccgcgcag  ctgaacatt  tatttactc  1860
cgttttaca  gagggaagc  agtttgtgg  tcgcggctt  attttctta  aaagccgca  1920
aataaatgg  cctggattt  caactcccc  aatttgtca  cttttgtct  ctggtgcac  1980
tcagatgct  tttcctgaa  gaaagcttg  agttttggg  tgtcctttt  tagaggcag  2040
tcctgaagg  gatttacaa  ccgggcgtt  ggcttgagc  cagactgcc  gtttgtgta  2100
acagtttta  tgtctctcg  tgaattttt  ttttttttg  ttctttttt  ccggagctg  2160
ggatcgaac  cagggcctt  cacttccta  gcaagcgct  taccactga  ctaaatccc  2220
aacccctct  gatgaattt  taacaaggc  gtttatttg  tccttaaat  gtatcacct  2280
attcacata  gactagcct  gcagaaact  aatctagat  tttacatcc  acgaggctc  2340
atcccactc  tgtacagcc  cagcacttg  gaggccaaa  caggcatat  tcctgagct  2400
aagaccagt  tggtctaca  agtgagctc  agggcagtt  tgggtgaga  aaaggtgct  2460
cacagcatc  ttgccttgg  ctctgccca  taggtggca  tagtacccc  gcctaactg  2520
ctctagaaa  tgcgcatgt  tcgcccctg  cacttgggg  ctgaaaata  gagaatcag  2580
agctcatgg  cattctctg  ttcgttatg  agtaggtta  cttgggcca  agaggttat  2640
acagatagc  aaaaatggt  gtgagctat  ggccaagag  agtgctttt  aaacatggt  2700
ggaaggaac  ggagagatg  ctcagtggt  tagagtggt  ctgctcata  ggacagaag  2760
gccagtttt  atttctagt  cccaggtgg  tagctcaca  cttgcttta  ctccatatg  2820
gggtgggac  ggtgtcttt  ggcttctgt  gtacactca  acttttgtg  atatgccca  2880
aaaggagga  gaggagtac  aatgatcgt  ataaaaaat  aagccggca  ggtagcaca  2940
gcctttaat  tcagcactt  ggaggcaga  gcaggagga  cattgtaat  tttaggtca  3000
cctgtctat  taggattta  ggttagcta  agaaaccct  cttcaataa  aaaaaaaaa  3060
aaaaaaaaa  aaatcaggg  ttcaaagat  ctcagcagg  gaaggagct  gcaagccca  3120
gacggtgca  caatgtctg  gacccactg  agaagggga  aacctatat  cccacacac  3180
agtggtctc  gacagtggc  gtatacatg  acactcaaa  caaaaggta  tgaggaaaa  3240
gatagaatc  tggttgcag  tttctggtc  tgcattaaa  agcatccac  tctgccatc  3300
cccttctga  acaggaagg  ccacacctt  atggcacaa  cctggctgg  gcagtttcc  3360
ggggaagct  ggaactgct  ttcttatat  aaaaatgtt  attatggat  gatacctat  3420
tgtgtacat  tgtacctgt  agtgcaggt  tctgtgggg  cagaggtgt  agatcccgg  3480
agcagttgt  agacacctg  tctgatgtc  gagaatttt  gaggagcaa  tctgatgaa  3540
ggagccatc  ttccaacat  ttatgtttt  taaggttta  tttctttta  attacgtgt  3600
tgcatgtgg  tgcccaagg  agccaaaga  ggcttcagg  tccctgggg  tggagtagt  3660
gcagttatg  gctgcctgg  gtggatgct  ggaaccaaa  ttgttctat  catgggcag  3720
gcagtacat  gccttagct  ctgagccat  tccttccct  gagcttgct  tactactag  3780
cacttcaga  gagagatgg  tcggtggtt  gagcaccgg  tgctcttcc  ggggtcctg  3840
gttcgattt  cagcaacca  atggtggct  acaaccatc  gtaatggga  ctgaatccc  3900
cttttgtgt  ggtgaagac  tagtgttta  acataaata  attaaagta  ataaaaaat  3960
taacaagaa  aactatggg  cagttgaaa  tatgccagt  aaggacaaa  ttccgtttg  4020
attttgttt  atctgtttc  agcagttgg  aggcaagtt  tttgtgagc  ttttcggga  4080
acatctaat  gccatcttc  ctccacagc  cttcccctg  ggagatggt  accataccc  4140
cttccacaa  cctcacatg  acccgcttc  gactggcta  gaagatgag  aaagagaac  4200
tggctcttc  cccaggcga  aagggacca  agcactgat  tggaccctg  ctcttgtgt  4260
tggaccacg  aagcccatt  gatgctcag  tcatctttc  tttatcaga  ggtgaccat  4320
actttgctc  tccatccct  tgctcgtaa  aggagatgg  ttaaataaa  aacttgaac  4380
gagattgtc  gtgggctgg  tgctgcatt  ttattctca  attaattgc  ttgctgctt  4440
tagatct  4447



<210> 9989
<211> 111
<212> PRT
<213> Rattus norvegicus
<308> CAA51286
<400> 9989

Met Ala Ser Ala Val Leu Ser Ala Ser Arg Val Ser Gly Leu Leu Gly 
  1               5                  10                  15
Arg Ala Leu Pro Arg Val Gly Arg Pro Met Ser Ser Gly Ala His Gly 
             20                  25                  30
Glu Glu Gly Ser Ala Arg Ile Trp Lys Ala Leu Thr Tyr Phe Val Ala 
         35                  40                  45
Leu Pro Gly Val Gly Val Ser Met Leu Asn Val Phe Leu Lys Ser Arg 
     50                  55                  60
His Glu Glu His Glu Arg Pro Glu Phe Val Ala Tyr Pro His Leu Arg 
 65                  70                  75                  80
Ile Arg Thr Lys Pro Phe Pro Trp Gly Asp Gly Asn His Thr Leu Phe 
                 85                  90                  95
His Asn Pro His Met Asn Pro Leu Pro Thr Gly Tyr Glu Asp Glu 
             100                105                110



<210> 9990
<211> 4447
<212> DNA
<213> Rattus norvegicus
<308> X72757
<400> 9990

gatccacct  cctctgctt  ctgagtgct  gtattaaag  tgtgtgcca  caccatcca  60
caatacacc  gtttttttt  tttaattgt  catatagtt  agtatggcc  tgaactcat  120
aagcatgag  ctgctgcct  tacctcctt  tgttatttt  agatagggt  tcataccat  180
gacaaggct  atcacagac  ctatatgtg  tccagagtg  cctctaatt  gagattccc  240
cctcggtct  tcagaactg  gccatatac  catacattt  aacttgggg  tgtgtgggt  300
gagacaggg  ttcacttta  agcccaggc  agtctctaa  tcacaacaa  cctcctgac  360
catctcact  ttgctggga  tatgagcca  ctgccacca  gcttcccgt  ttgtgttgt  420
tttgtttca  ggagaaggg  ctcactatg  agcccctgg  cagcctgga  ctctcggta  480
aagaaagag  ctatcctgg  atcagtcca  cgtcttcct  caagatgcc  ccacacctg  540
cattccagc  tttttaaaa  aaaaaactt  tatctttaa  aaggcgttt  gacaaaaag  600
aagaaaaaa  aaagcagat  tttaaaaag  tctacagac  aaatttaac  gatctttgt  660
gaattcgag  gagagagca  gaccattgg  caatcgctg  ggatatgga  ctgaaacaa  720
gtccagatt  tctggcacc  attccaggg  tctttctgg  tccaggagc  attcattga  780
tcattaatt  atggattca  aattcatat  ttcattaaa  tgcataaag  acctgctac  840
tgatttcgg  taactctgg  aatgcagcg  tggcaaaat  taagcacca  ggactttac  900
gtccatata  ggcgtcaca  aagagaata  caacggtct  taagagtga  gacaagggt  960
tcgggtgcc  tggaaatcg  ggaattaga  gtcagcgag  aaaggagaa  ggcgcttcc  1020
ataacgtca  ttgttctcg  catttcaga  cctgtccag  gactccaaa  aaggtagca  1080
ttaaaaaca  aacaaaaaa  tatctcaca  aagctctat  cagcgaaca  cctcaccca  1140
cagcagagg  gggaggtgg  gcacaggta  gaaacgcat  cgcaatctc  ctcgtgccg  1200
cccgagggt  tggaccagg  ccgaaaatg  gcgcaggcg  tacaattcc  ggccagtga  1260
aaggcgttg  ccaatgaaa  ttcgtttgg  gtctctgtc  cgccccctt  gggaccccc  1320
tttccgctt  cggcgcgcc  ggtagttcc  agatggcgt  ggcggtgct  agtgcgtct  1380
gagtctctg  gctgctggg  cgggccctc  cacgggtgg  gcggcccat  tcgagtggc  1440
cccacggcg  ggagggttc  ggtaccggg  ctcgggtgg  cgtgggggc  tcagtggct  1500
gcacgcggc  tggcggggc  gtgaccttg  cgggaggcc  tgcgggagg  agcggccga  1560
gctgacatt  tggtccccg  tgcagctcg  atttggaag  ccctcacct  cttcgtggc  1620
ctgcccggg  tgggagtga  catgctcaa  gttttcctg  agtcgcgac  cgaagagca  1680
gagagaccc  agttcgtcg  ctaccccca  ctccgcatc  ggactaagg  acgcgctgc  1740
cctctgctg  ccttcaagc  tccgttatt  ctgggttgt  cactcccca  tcccagccc  1800
tggtgcgct  ggatctcgg  tgcctgtct  tccgcgcag  ctgaacatt  tatttactc  1860
cgttttaca  gagggaagc  agtttgtgg  tcgcggctt  attttctta  aaagccgca  1920
aataaatgg  cctggattt  caactcccc  aatttgtca  cttttgtct  ctggtgcac  1980
tcagatgct  tttcctgaa  gaaagcttg  agttttggg  tgtcctttt  tagaggcag  2040
tcctgaagg  gatttacaa  ccgggcgtt  ggcttgagc  cagactgcc  gtttgtgta  2100
acagtttta  tgtctctcg  tgaattttt  ttttttttg  ttctttttt  ccggagctg  2160
ggatcgaac  cagggcctt  cacttccta  gcaagcgct  taccactga  ctaaatccc  2220
aacccctct  gatgaattt  taacaaggc  gtttatttg  tccttaaat  gtatcacct  2280
attcacata  gactagcct  gcagaaact  aatctagat  tttacatcc  acgaggctc  2340
atcccactc  tgtacagcc  cagcacttg  gaggccaaa  caggcatat  tcctgagct  2400
aagaccagt  tggtctaca  agtgagctc  agggcagtt  tgggtgaga  aaaggtgct  2460
cacagcatc  ttgccttgg  ctctgccca  taggtggca  tagtacccc  gcctaactg  2520
ctctagaaa  tgcgcatgt  tcgcccctg  cacttgggg  ctgaaaata  gagaatcag  2580
agctcatgg  cattctctg  ttcgttatg  agtaggtta  cttgggcca  agaggttat  2640
acagatagc  aaaaatggt  gtgagctat  ggccaagag  agtgctttt  aaacatggt  2700
ggaaggaac  ggagagatg  ctcagtggt  tagagtggt  ctgctcata  ggacagaag  2760
gccagtttt  atttctagt  cccaggtgg  tagctcaca  cttgcttta  ctccatatg  2820
gggtgggac  ggtgtcttt  ggcttctgt  gtacactca  acttttgtg  atatgccca  2880
aaaggagga  gaggagtac  aatgatcgt  ataaaaaat  aagccggca  ggtagcaca  2940
gcctttaat  tcagcactt  ggaggcaga  gcaggagga  cattgtaat  tttaggtca  3000
cctgtctat  taggattta  ggttagcta  agaaaccct  cttcaataa  aaaaaaaaa  3060
aaaaaaaaa  aaatcaggg  ttcaaagat  ctcagcagg  gaaggagct  gcaagccca  3120
gacggtgca  caatgtctg  gacccactg  agaagggga  aacctatat  cccacacac  3180
agtggtctc  gacagtggc  gtatacatg  acactcaaa  caaaaggta  tgaggaaaa  3240
gatagaatc  tggttgcag  tttctggtc  tgcattaaa  agcatccac  tctgccatc  3300
cccttctga  acaggaagg  ccacacctt  atggcacaa  cctggctgg  gcagtttcc  3360
ggggaagct  ggaactgct  ttcttatat  aaaaatgtt  attatggat  gatacctat  3420
tgtgtacat  tgtacctgt  agtgcaggt  tctgtgggg  cagaggtgt  agatcccgg  3480
agcagttgt  agacacctg  tctgatgtc  gagaatttt  gaggagcaa  tctgatgaa  3540
ggagccatc  ttccaacat  ttatgtttt  taaggttta  tttctttta  attacgtgt  3600
tgcatgtgg  tgcccaagg  agccaaaga  ggcttcagg  tccctgggg  tggagtagt  3660
gcagttatg  gctgcctgg  gtggatgct  ggaaccaaa  ttgttctat  catgggcag  3720
gcagtacat  gccttagct  ctgagccat  tccttccct  gagcttgct  tactactag  3780
cacttcaga  gagagatgg  tcggtggtt  gagcaccgg  tgctcttcc  ggggtcctg  3840
gttcgattt  cagcaacca  atggtggct  acaaccatc  gtaatggga  ctgaatccc  3900
cttttgtgt  ggtgaagac  tagtgttta  acataaata  attaaagta  ataaaaaat  3960
taacaagaa  aactatggg  cagttgaaa  tatgccagt  aaggacaaa  ttccgtttg  4020
attttgttt  atctgtttc  agcagttgg  aggcaagtt  tttgtgagc  ttttcggga  4080
acatctaat  gccatcttc  ctccacagc  cttcccctg  ggagatggt  accataccc  4140
cttccacaa  cctcacatg  acccgcttc  gactggcta  gaagatgag  aaagagaac  4200
tggctcttc  cccaggcga  aagggacca  agcactgat  tggaccctg  ctcttgtgt  4260
tggaccacg  aagcccatt  gatgctcag  tcatctttc  tttatcaga  ggtgaccat  4320
actttgctc  tccatccct  tgctcgtaa  aggagatgg  ttaaataaa  aacttgaac  4380
gagattgtc  gtgggctgg  tgctgcatt  ttattctca  attaattgc  ttgctgctt  4440
tagatct  4447



<210> 9991
<211> 111
<212> PRT
<213> Rattus norvegicus
<308> CAA51286
<400> 9991

Met Ala Ser Ala Val Leu Ser Ala Ser Arg Val Ser Gly Leu Leu Gly 
  1               5                  10                  15
Arg Ala Leu Pro Arg Val Gly Arg Pro Met Ser Ser Gly Ala His Gly 
             20                  25                  30
Glu Glu Gly Ser Ala Arg Ile Trp Lys Ala Leu Thr Tyr Phe Val Ala 
         35                  40                  45
Leu Pro Gly Val Gly Val Ser Met Leu Asn Val Phe Leu Lys Ser Arg 
     50                  55                  60
His Glu Glu His Glu Arg Pro Glu Phe Val Ala Tyr Pro His Leu Arg 
 65                  70                  75                  80
Ile Arg Thr Lys Pro Phe Pro Trp Gly Asp Gly Asn His Thr Leu Phe 
                 85                  90                  95
His Asn Pro His Met Asn Pro Leu Pro Thr Gly Tyr Glu Asp Glu 
             100                105                110



<210> 9992
<211> 1448
<212> DNA
<213> Rattus norvegicus
<308> X73371
<400> 9992

cctctagat  catgctcga  cggccgcca  tgtggtgga  ttctgccaa  ctcggagag  60
agcctgtgc  tgcagctga  tcactccag  actgatggg  accctgctg  tcctaccgc  120
ccccatgga  agcaacagg  ctgtcgtcc  tgtgctctc  cggactttg  accatatgc  180
actgtggac  gctgtgcta  atcttgttg  tgagtctca  gcaggtctt  cgaaggctg  240
ggtgaaact  gagccccca  ggatccagg  gcttaagga  gacactgtg  cactgatgt  300
cgaagggac  cacaacacc  agaactgtt  tactcagtg  tttcacaat  ggagctcca  360
ctggcatca  gcccaagcc  actacacgt  taaggccac  gtcaatgat  gtggagaat  420
ccggtgccg  atggaggag  ccggcatca  cgaacccat  catctggga  tgatttctg  480
ctggctgct  ctccagacc  ctcaactgg  gtttgaaga  ggggaaacc  tcacattaa  540
gtgccatag  tggaagaac  aacagctga  taaggtctt  ttgttccag  atggaaaac  600
tgtgaggta  tatcatcaa  gcagcaatt  ttcaatccc  aaagccaac  acagtcaca  660
tgggaacta  tattgcaaa  catatctag  aaggacaat  cacgtgtcc  agcctgtca  720
catcactgt  caagagccc  aatccagca  ttcgttgcc  gtattgacg  ttgtagctg  780
tgtcgctgg  attgctgta  ctgccattg  tattatcct  gtatccttg  tctatctca  840
gaaaaagca  gttccagac  ctccttctg  tctcgaaga  gctgagaaa  atgaggtgg  900
gaatacaat  acctattca  ttctcaagc  tcctgaagc  ccggatgaa  aatcagatc  960
cgactacca  aaccacatt  agtctctct  gagattggg  aaagcaaac  agtaaggcc  1020
ggacctagc  tctcctggt  caaggaatg  tgtagatat  aaagaaaac  tctagagtc  1080
cttctgtga  tcctgaaac  aacagacac  acgatattg  ttcccaatg  ttgactgta  1140
taatgactt  cataactta  agcttccca  ctaaagact  ttttgctat  gatccacac  1200
gccaataaa  ttaatcaac  tactgttgt  aagagacta  agcaacgtg  gaactgctt  1260
tattacatg  taaggagaa  aagtaacat  aggatgcat  atctcagcg  ggatcaact  1320
gacgtgtac  aacctgtca  aagtgatgc  tctttataa  aaactttat  tccttattt  1380
tctataaag  tcacatatt  cttttatag  aaaatgttg  gaaaatgtc  aaaaaaaaa  1440
aaaaaaaa  1448



<210> 9993
<211> 285
<212> PRT
<213> Rattus norvegicus
<308> Q63203
<400> 9993

Met Asp Ser Asn Arg Thr Val Val His Val Leu Ser Arg Thr Leu Tyr 
  1               5                  10                  15
His Met Leu Leu Trp Thr Ala Val Leu Asn Leu Val Ala Glu Ser His 
             20                  25                  30
Ala Gly Leu Pro Lys Ala Val Val Lys Leu Glu Pro Pro Trp Ile Gln 
         35                  40                  45
Val Leu Lys Glu Asp Thr Val Thr Leu Met Cys Glu Gly Thr His Asn 
     50                  55                  60
Thr Lys Asn Cys Ser Thr Gln Trp Phe His Asn Gly Ser Ser Ile Trp 
 65                  70                  75                  80
His Gln Ala Gln Ala Asn Tyr Thr Phe Lys Ala Thr Val Asn Asp Ser 
                 85                  90                  95
Gly Glu Tyr Arg Cys Arg Met Glu Glu Thr Gly Ile Ser Glu Pro Ile 
             100                105                110
His Leu Gly Val Ile Ser Asp Trp Leu Leu Leu Gln Thr Ser Gln Leu 
         115                120                125
Val Phe Glu Glu Gly Glu Thr Ile Thr Leu Arg Cys His Ser Trp Lys 
     130                135                140
Asn Lys Gln Leu Thr Lys Val Leu Leu Phe Gln Asn Gly Lys Pro Val 
 145                150                155                160
Arg Tyr Tyr His Gln Ser Ser Asn Phe Ser Ile Pro Lys Ala Asn His 
                 165                170                175
Ser His Ser Gly Asn Tyr Tyr Cys Lys Ala Tyr Leu Gly Arg Thr Met 
             180                185                190
His Val Ser Lys Pro Val Thr Ile Thr Val Gln Glu Pro Lys Ser Ser 
         195                200                205
Ser Ser Leu Pro Val Leu Thr Ile Val Ala Ala Val Ala Gly Ile Ala 
     210                215                220
Val Ala Ala Ile Val Ile Ile Leu Val Ser Leu Val Tyr Leu Lys Lys 
 225                230                235                240
Lys Gln Val Pro Asp Thr Pro Ser Gly Leu Glu Glu Ala Glu Lys Asn 
                 245                250                255
Glu Val Glu Asn Thr Ile Thr Tyr Ser Leu Leu Lys His Pro Glu Ala 
             260                265                270
Pro Asp Glu Glu Ser Asp His Asp Tyr Gln Asn His Ile 
         275                280                285



<210> 9994
<211> 1466
<212> DNA
<213> Homo sapiens
<308> NM_004001
<400> 9994

gccctctag  gtagaatcg  caagctttg  gagaaggct  tgactgctg  gctctgggc  60
ccagctcgc  ccagggagt  atgggaatc  tgtcattct  acctgtcct  gccactgag  120
gtgactggg  tgactgcaa  tccccccag  cttggggtc  tatgcttct  tggacagct  180
tgctattcc  ggcagctcc  ccaaaggct  tgctgaaac  cgagcccca  tggatcaac  240
tgctccagg  ggactctgt  actctgaca  gccggggga  tcacagccc  gagagcgac  300
ccattcagt  gttccacaa  gggaatctc  ttcccaccc  cacgcagcc  agctacagg  360
tcaaggcca  caacaatga  agcggggag  acacgtgcc  gactggcca  accagcctc  420
gcgaccctg  gcatctgac  gtgctttct  agtggctgg  gctccagac  cctcacctg  480
agttccagg  gggagaaac  atcgtgctg  ggtgccaca  ctggaagga  aagcctctg  540
tcaaggtca  attcttcca  aatggaaaa  ccaagaaat  ttcccgttc  gatcccaac  600
tctccatcc  acaagcaaa  cacagtcac  gtggtgatt  ccactgcac  ggaaacata  660
gctacacgc  gttctcatc  aagcctgtg  ccatcactg  ccaagctcc  agctcttca  720
cgatgggga  cattgtggc  gtggtcact  ggattgctg  agcggccat  gttgctgct  780
tagtggcct  gatctactg  aggaaaaag  ggatttcag  tctcccagg  taccctgag  840
gcagggaaa  gggagagac  ctccctgag  aaccagcca  tcccactaa  cctgatgag  900
ctgacaaag  tggggctga  aacacaatc  cctattcac  tctcatgca  ccggatgct  960
tggaagagc  tgatgacca  aaccgtatt  agtctccat  gtcttgcat  gggatttga  1020
aagaaaatc  gagagggaa  atctggtat  tcctggcct  aattcccct  ggaggacag  1080
gagatgctc  agttccaaa  gagaaggtt  cttccagag  catctacct  agtcctgaa  1140
ctccctgtc  tgaaagcca  agacaatat  gtcccaaat  accgactgc  cctgctgtc  1200
tcagctctt  ttgacatca  ggctcttcc  ttccacatc  acacagcca  tccaattaa  1260
caaaccact  ttattaaca  ataatagca  cttgggaaa  gcttatgtt  caggttacc  1320
ttgagaaca  tcatctaaa  ctatatgat  tcagaaatg  taaaataga  taacctcta  1380
cagcacatt  aaagtgatt  tttctgggt  atttattga  gatttttat  ttctttatt  1440
ttctataaa  atcatatat  actttt  1466



<210> 9995
<211> 310
<212> PRT
<213> Homo sapiens
<308> P31994
<400> 9995

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
  1               5                  10                  15
Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
             20                  25                  30
Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Ala Pro Pro 
         35                  40                  45
Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu 
     50                  55                  60
Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp 
 65                  70                  75                  80
Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln 
                 85                  90                  95
Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr 
             100                105                110
Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val 
         115                120                125
Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu 
     130                135                140
Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu 
 145                150                155                160
Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg 
                 165                170                175
Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly 
             180                185                190
Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys 
         195                200                205
Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile 
     210                215                220
Ile Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala 
 225                230                235                240
Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Leu Pro 
                 245                250                255
Gly Tyr Pro Glu Cys Arg Glu Met Gly Glu Thr Leu Pro Glu Lys Pro 
             260                265                270
Ala Asn Pro Thr Asn Pro Asp Glu Ala Asp Lys Val Gly Ala Glu Asn 
         275                280                285
Thr Ile Thr Tyr Ser Leu Leu Met His Pro Asp Ala Leu Glu Glu Pro 
     290                295                300
Asp Asp Gln Asn Arg Ile 
 305                310



<210> 9996
<211> 1525
<212> DNA
<213> Rattus norvegicus
<308> X73653
<400> 9996

ggccaagag  acgaagtct  ttttttttt  ttcttgcgg  agaacttaa  gctgcattt  60
ttattaacc  agtacccta  cataaaaca  aaggaagaa  aggattaag  aaggaaaag  120
tgaatcgag  agagccatc  tgtcggggc  accgagaac  acctccttt  cggagagct  180
caagccagt  cagcagcct  cagcttttg  tagcatgaa  gttagcaga  ataaagatg  240
cagcaaggt  accacagtg  tggcaactc  tggacaggg  cctgacagg  cacaggaag  300
cagttacac  gacactaaa  tcattggaa  tgggtcatt  ggtgtggta  atcaagcca  360
actttgtga  tcaggagaa  tggtggcca  caagaaagt  cttcaggac  agcgattta  420
gaaccgaga  ctccagatc  tgagaaagc  agatcactg  aacatagtc  gattgcggt  480
tttcttcta  tcgagtggc  agaagaaag  tgaggtcta  cttaacctg  tgctggact  540
tgttccgga  acagtgtac  gagtcgcca  acactatag  cgagccaag  agacactcc  600
tgtgatcta  gtcaagttg  atatgtacc  gctgttcag  agtctagcc  atatccatt  660
ctttgggat  tgccatcga  acattaaac  acagaacct  ttgctggat  ctgatacag  720
tgtattaaa  ctctgcgac  ttggaagtg  aaagcagct  gtccgagga  agcccaatg  780
ttcatatat  tgttctcgg  actacaggg  accagagct  atctttgga  ccaccgatt  840
cacgtctag  atagatgta  ggtctgcag  ctgtgtgtt  gctgaattg  tgctaggac  900
accaatatt  cctggggac  gtggtgtgg  tcagttggt  gaaataata  aggtcctag  960
aacaccaac  agggagcaa  ttagagaaa  gaacccaaa  tatacagaa  tcaaattcc  1020
ccaaatcaa  gcacatcct  ggacgaagg  ctttcggcc  cgaactcca  cagaggcaa  1080
cgcactgtg  agccgtctc  tggagtaca  gccgaccgc  cggctaaca  cactggaag  1140
ttgtgcaca  tcatttttt  atgaattac  ggacccaaa  gtcaaacta  caaatgggc  1200
agacacacc  gccctcttc  actttacca  tcaagaact  tcaagtaac  cacctctgg  1260
caccatcct  atccctcct  acgctcgga  tcaggcagc  gcttcaccg  ctgcaaacg  1320
cacagcagc  tcagatact  atgctggag  ccgtggaca  accaataac  ccgcttctg  1380
atcagcctc  aactctacc  gaacagccc  aagtagcca  ctgcgcagg  aagaccagc  1440
cttacttga  tgccactca  caacactgg  cacgtttgg  aagaaaatt  aaaagagga  1500
aacaaaaac  aaaacaaaa  acccc  1525



<210> 9997
<211> 420
<212> PRT
<213> Rattus norvegicus
<308> P18266
<400> 9997

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
  1               5                  10                  15
Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
             20                  25                  30
Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
         35                  40                  45
Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
     50                  55                  60
Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
 65                  70                  75                  80
Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                 85                  90                  95
Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
             100                105                110
Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
         115                120                125
Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
     130                135                140
His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
 145                150                155                160
Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                 165                170                175
Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
             180                185                190
Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
         195                200                205
Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
     210                215                220
Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Met 
 225                230                235                240
Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                 245                250                255
Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
             260                265                270
Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
         275                280                285
Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val 
     290                295                300
Phe Arg Pro Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu 
 305                310                315                320
Leu Glu Tyr Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala 
                 325                330                335
His Ser Phe Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn 
             340                345                350
Gly Arg Asp Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser 
         355                360                365
Ser Asn Pro Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile 
     370                375                380
Gln Ala Ala Ala Ser Pro Pro Ala Asn Ala Thr Ala Ala Ser Asp Thr 
 385                390                395                400
Asn Ala Gly Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala 
                 405                410                415
Ser Asn Ser Thr 
             420



<210> 9998
<211> 1639
<212> DNA
<213> Homo sapiens
<308> BC000251
<400> 9998

atcatctat  tgttaaata  ccgtgccga  ctgtcttga  ggagaaata  atcgcttgt  60
ttgtttttt  tagtataca  aaggagtga  aagccaaga  gacgaagtc  ttttctttt  120
cttctgtgg  agaacttaa  gctgcattt  tcgttaacc  aacacccca  cataaagac  180
aaaggaaga  aaggaggaa  gaaggaaaa  gtgattcgc  aagagagtg  tcatgtcag  240
gcggcccag  accacctcc  ttgcggaga  ctgcaagcc  gtgcagcag  cttcagctt  300
tggcagcat  aaagttagc  gagacaagg  cggcagcaa  gtgacaaca  tggtggcaa  360
tcctgggca  ggtccagac  ggccacaag  agtcagcta  acagacact  aagtgattg  420
aaatggatc  tttggtgtg  tatatcaag  caaactttg  gattcagga  aactggtcg  480
catcaagaa  gtattgcag  acaagagat  taagaatcg  gagctccag  tcatgagaa  540
gctagatca  tgtaacata  tccgattgc  ttatttctt  tactccagt  gtgagaaga  600
agatgaggt  tatcttaat  tggtgctgg  ctatgttcc  gaaacagta  acagagttg  660
cagacacta  agtcgagcc  aacagacgc  ccctgtgat  tatgtcaag  tgtatatgt  720
tcagctgtt  cgaagttta  cctatatcc  ttcctttgg  atctgccat  gggatatta  780
accgcagaa  ctcttgttg  atcctgata  tgctgtatt  aaactctgt  actttggaa  840
tgcaaagca  ctggtccga  gagaaccca  tgtttcgta  atctgttct  ggtactata  900
ggcaccaga  ttgatcttt  gagccactg  ttatacctc  agtatagat  tatggtctg  960
tggctgtgt  ttggctgag  tgttactag  acaaccaat  tttccaggg  atagtggtg  1020
ggatcagtt  gtagaaata  tcaaggtcc  gggaactcc  acaagggag  aaatcagag  1080
aatgaaccc  aactacaca  aatttaaat  ccctcaaat  aaggcacat  cttggacta  1140
ggattcgtc  ggaacagga  atttcacct  aggagtgcg  gtcttccga  cccgaactc  1200
accggaggc  attgcactg  gtagccgtc  gctggagta  acaccaact  cccgactaa  1260
accactgga  gcttgtgca  attcatttt  tgatgaatt  cgggaccca  atgtcaaac  1320
accaaatgg  cgagacaca  ctgcactct  caacttcac  actcaagaa  tgtcaagta  1380
tccacctct  gctaccatc  ttattcctc  tcatgctcg  attcaagca  ctgcttcaa  1440
ccccacaaa  gccacagca  cgtcagatg  taatactgg  gaccgtgga  agaccaata  1500
tgctgcttc  gcatcagct  ccaactcca  ctgaacagt  ccgagcagc  agctgcaca  1560
gaaaaacca  cagttactt  agtgtcact  agcaacact  gtcacgttt  gaaagaata  1620
taaaaaaaa  aaaaaaaaa  1639



<210> 9999
<211> 420
<212> PRT
<213> Homo sapiens
<308> P49841
<400> 9999

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
  1               5                  10                  15
Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
             20                  25                  30
Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
         35                  40                  45
Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
     50                  55                  60
Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
 65                  70                  75                  80
Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                 85                  90                  95
Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
             100                105                110
Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
         115                120                125
Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
     130                135                140
His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
 145                150                155                160
Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                 165                170                175
Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
             180                185                190
Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
         195                200                205
Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
     210                215                220
Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
 225                230                235                240
Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                 245                250                255
Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
             260                265                270
Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
         275                280                285
Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val 
     290                295                300
Phe Arg Pro Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu 
 305                310                315                320
Leu Glu Tyr Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala 
                 325                330                335
His Ser Phe Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn 
             340                345                350
Gly Arg Asp Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser 
         355                360                365
Ser Asn Pro Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile 
     370                375                380
Gln Ala Ala Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala 
 385                390                395                400
Asn Thr Gly Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala 
                 405                410                415
Ser Asn Ser Thr 
             420



<210> 10000
<211> 2668
<212> DNA
<213> Rattus norvegicus
<308> X73911
<400> 10000

gagtggcca  gagcaaagt  tggaagccg  cgagccacg  agcagagca  acagagcta  60
gaggcttgc  caaatgtgt  tggccttcg  ctgggcagc  gtcatattg  ttctacaga  120
ggtagacac  gcatctgct  tgaggactc  ttatgacaa  gcgagggta  ttgcagacc  180
gagccccca  gagataaag  ctgttcaca  cttcctgat  aacagggag  agctggggc  240
gcagccgtc  aaggaaccg  ctttggcca  aaactctgt  tttctcatt  agatgctac  300
gcccaagaa  aagcatgtg  tgaaatttc  ggatgaagg  agaaaaggt  ctaaccggg  360
agctagggc  gtcatcttc  tcggtgccc  ggactaccc  aatgtcact  agtttgctg  420
ggggcccct  ccacggccc  actatattc  agcactatc  cccaggcca  ggcaccatc  480
gtcctggtc  tccaggccc  tctccacag  agagtacga  ctcctctac  acacgctga  540
gagagccac  atgcctctg  accagtttt  ccttgacac  actggcttc  cattcctag  600
ctgtgacga  cgatgcttg  cttttactg  cgtagctcc  cgtggtgtg  cgtctggtc  660
gcgtagaag  tggtttatt  tgcagcgct  tgtggaagg  tatttcctg  atcctacag  720
gctggagat  ctattggat  atgggagca  agatgtcca  gactggaga  tggagcagc  780
ctggtataa  ggcaagttc  acaacaacc  agaggaact  gctcggaaa  acgcagttg  840
agaagtgga  acggtggtc  tcgaggacc  actgcccaa  ggcacagag  agcccccac  900
cttttcttc  tacaaaccc  ggggggaat  ccatacacc  gtcaatgtt  ctggccccc  960
cgttgtcca  cccagcggc  cccgatata  actagaggg  aacactgtg  tctatggag  1020
ttggagctt  tcttatcgg  taagatcct  ttctgggct  cagatcttc  atgtgctct  1080
tggaggtga  cgtgttgcc  acgaggtca  tgtgcagga  gctgtggca  tgtatggag  1140
acacacacc  gcaggcatg  agactaagt  cattgatgt  ggctggggc  tgggcagtg  1200
cactcacga  ttggcccct  gcattgact  tccagagac  gctactttc  tggatgcct  1260
ccactatta  gacagcgat  gccctgtcc  ttatccaca  gctctgtgc  tctttgaga  1320
gcccacagg  gtgcccctg  ggcgccact  taactcaaa  tttaaaggt  gcttcaact  1380
ctatgcggg  ttgaaggga  atgtgctgg  gctacggac  acatcaact  tctataatt  1440
tgattacat  tgggatttc  tcttctact  taacggggt  atggaggcc  agatgcacg  1500
cactggcta  gtccatgcg  ccttctaca  tcctgaggg  ctgcgccat  gcactcgct  1560
acaaaccca  ctgcttggt  acatccaca  ccacctggt  cactaccgt  ttgacatgg  1620
cgtggcagg  accaagaac  gcttccaga  actgacgat  aagctggaa  acctcacca  1680
tccctggag  ccaagtcac  ccctggtcc  gcccacact  gagcagacc  agtactccc  1740
ggagcacca  gctgcattc  gcttcggac  gactctgcc  aagtacctg  tctttagca  1800
cccccaaaa  aactgctgg  gtcacaggc  cagctaccg  ctgcagatc  attctatgg  1860
tgagcaggt  ctgccacca  gctggcagg  ggagcgggc  gtcacttgg  ccaggtatc  1920
tttggctgt  acaaagtat  gggaatctg  gcgctacag  agcagcctc  acaaccaga  1980
tgacccctg  gatcccccc  tggtctttg  ggagttcct  cggaacaac  agaacattg  2040
agatgagga  ttggtggcc  gggtgacag  gggcttcct  cacatccct  actcagaag  2100
tgtccccaa  acagccaca  ctggaaact  tgtgggctt  ttgctccgg  ccttcaact  2160
cttcccaga  gacccatcc  tggcttcta  agacactgt  atagtgtgg  cccaggaca  2220
gggcctcaa  cgtgtccag  gctggatcc  tgaggacag  cgctgcttg  tgtctcctc  2280
tttcagcta  aatgggacc  acaagcctg  gtgatgggt  agccccagc  tctgcagca  2340
acccagagc  tcacaaaga  agggaaaac  aacaaacga  acttctgtc  ctaccctgt  2400
tgctacctt  tagctctac  cgtgtttca  taccatacc  gccacagac  tccaagacc  2460
ttgcaaagg  aggaccaca  ttttctgcc  gtggttcgg  ggtttggag  gtggtgttt  2520
ttaaatatt  gaggtgttt  tcttcctat  aggagactt  agagaaatt  tctcacctc  2580
gtgatggga  ggagtaagg  aactgtcat  tgaaaatct  ataaaatga  acctttgct  2640
tttagacat  aaaaaaaaa  aaaaaaaa  2668



<210> 10001
<211> 746
<212> PRT
<213> Rattus norvegicus
<308> P36633
<400> 10001

Met Cys Leu Ala Phe Gly Trp Ala Ala Val Ile Leu Val Leu Gln Thr 
  1               5                  10                  15
Val Asp Thr Ala Ser Ala Val Arg Thr Pro Tyr Asp Lys Ala Arg Val 
             20                  25                  30
Phe Ala Asp Leu Ser Pro Gln Glu Ile Lys Ala Val His Ser Phe Leu 
         35                  40                  45
Met Asn Arg Glu Glu Leu Gly Leu Gln Pro Ser Lys Glu Pro Thr Leu 
     50                  55                  60
Ala Lys Asn Ser Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Lys 
 65                  70                  75                  80
His Val Leu Lys Phe Leu Asp Glu Gly Arg Lys Gly Pro Asn Arg Glu 
                 85                  90                  95
Ala Arg Ala Val Ile Phe Phe Gly Ala Gln Asp Tyr Pro Asn Val Thr 
             100                105                110
Glu Phe Ala Val Gly Pro Leu Pro Arg Pro Tyr Tyr Ile Arg Ala Leu 
         115                120                125
Ser Pro Arg Pro Gly His His Leu Ser Trp Ser Ser Arg Pro Ile Ser 
     130                135                140
Thr Ala Glu Tyr Asp Leu Leu Tyr His Thr Leu Lys Arg Ala Thr Met 
 145                150                155                160
Pro Leu His Gln Phe Phe Leu Asp Thr Thr Gly Phe Ser Phe Leu Gly 
                 165                170                175
Cys Asp Asp Arg Cys Leu Thr Phe Thr Asp Val Ala Pro Arg Gly Val 
             180                185                190
Ala Ser Gly Gln Arg Arg Ser Trp Phe Ile Val Gln Arg Tyr Val Glu 
         195                200                205
Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Ile Leu Leu Asp His Gly 
     210                215                220
Ser Thr Asp Val Gln Asp Trp Arg Val Glu Gln Leu Trp Tyr Asn Gly 
 225                230                235                240
Lys Phe Tyr Asn Asn Pro Glu Glu Leu Ala Arg Lys Tyr Ala Val Gly 
                 245                250                255
Glu Val Asp Thr Val Val Leu Glu Asp Pro Leu Pro Asn Gly Thr Glu 
             260                265                270
Lys Pro Pro Leu Phe Ser Ser Tyr Lys Pro Arg Gly Glu Phe His Thr 
         275                280                285
Pro Val Asn Val Ala Gly Pro His Val Val Gln Pro Ser Gly Pro Arg 
     290                295                300
Tyr Lys Leu Glu Gly Asn Thr Val Leu Tyr Gly Gly Trp Ser Phe Ser 
 305                310                315                320
Tyr Arg Leu Arg Ser Ser Ser Gly Leu Gln Ile Phe Asn Val Leu Phe 
                 325                330                335
Gly Gly Glu Arg Val Ala Tyr Glu Val Ser Val Gln Glu Ala Val Ala 
             340                345                350
Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln Thr Lys Tyr Ile Asp 
         355                360                365
Val Gly Trp Gly Leu Gly Ser Val Thr His Glu Leu Ala Pro Gly Ile 
     370                375                380
Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Ala Phe His Tyr Tyr Asp 
 385                390                395                400
Ser Asp Gly Pro Val His Tyr Pro His Ala Leu Cys Leu Phe Glu Met 
                 405                410                415
Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn Ser Asn Phe Lys Gly 
             420                425                430
Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Tyr Val Leu Val Leu Arg 
         435                440                445
Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile Trp Asp Phe Ile Phe 
     450                455                460
Tyr Ser Asn Gly Val Met Glu Ala Lys Met His Ala Thr Gly Tyr Val 
 465                470                475                480
His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg His Gly Thr Arg Leu 
                 485                490                495
Gln Thr His Leu Leu Gly Asn Ile His Thr His Leu Val His Tyr Arg 
             500                505                510
Val Asp Met Asp Val Ala Gly Thr Lys Asn Ser Phe Gln Thr Leu Thr 
         515                520                525
Met Lys Leu Glu Asn Leu Thr Asn Pro Trp Ser Pro Ser His Ser Leu 
     530                535                540
Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser Gln Glu His Gln Ala 
 545                550                555                560
Ala Phe Arg Phe Gly Gln Thr Leu Pro Lys Tyr Leu Leu Phe Ser Ser 
                 565                570                575
Pro Gln Lys Asn Cys Trp Gly His Arg Arg Ser Tyr Arg Leu Gln Ile 
             580                585                590
His Ser Met Ala Glu Gln Val Leu Pro Pro Gly Trp Gln Glu Glu Arg 
         595                600                605
Ala Val Thr Trp Ala Arg Tyr Pro Leu Ala Val Thr Lys Tyr Arg Glu 
     610                615                620
Ser Glu Arg Tyr Ser Ser Ser Leu Tyr Asn Gln Asn Asp Pro Trp Asp 
 625                630                635                640
Pro Pro Val Val Phe Glu Glu Phe Leu Arg Asn Asn Glu Asn Ile Glu 
                 645                650                655
Asp Glu Asp Leu Val Ala Trp Val Thr Val Gly Phe Leu His Ile Pro 
             660                665                670
His Ser Glu Asp Val Pro Asn Thr Ala Thr Pro Gly Asn Ser Val Gly 
         675                680                685
Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu Asp Pro Ser Leu Ala 
     690                695                700
Ser Arg Asp Thr Val Ile Val Trp Pro Gln Asp Lys Gly Leu Asn Arg 
 705                710                715                720
Val Gln Arg Trp Ile Pro Glu Asp Arg Arg Cys Leu Val Ser Pro Pro 
                 725                730                735
Phe Ser Tyr Asn Gly Thr Tyr Lys Pro Val 
             740                745



<210> 10002
<211> 2473
<212> DNA
<213> Homo sapiens
<308> U11863
<400> 10002

tcacagccc  gccgggcaa  ggctggaag  agagcgaac  gggagcaga  cacacagag  60
cgtggagcg  gagatgccg  ccctgggct  ggccgtggc  gccatcctg  tgctgcaga  120
ggccatggc  gagccctcc  cggggactc  gcccaggaa  gcaggggtg  tttcagacc  180
aagcaacca  gagctgaag  cagtgcaca  cttcctctg  tccaagaag  agctgaggc  240
gcagccctc  agtaccacc  ccatggcca  gaacaccgt  tttctcatc  agatgctgc  300
gcccaagaa  taccatgtg  tgaggtttc  ggataaagg  gaaaggcat  ctgtgcggg  360
agcccgtgc  gtcatcttc  ttggtgacc  ggagcatcc  aatgtcacc  agtttgctg  420
ggggcccct  ccagggccc  gctacatgc  agcactgtc  cccaggcct  ggtaccagt  480
ctcctgggc  tcgaggccc  tctccacag  agagtatgc  ctcctctac  acaccctgc  540
ggaagccac  aagcccctg  atcagttct  cctcaatac  acaggcttc  cattccaag  600
ctgccatga  agatgcctg  ccttcaccg  tgtggcccc  cggggtgtg  cttctggcc  660
gcgccgcag  tggcttatc  tacagcgct  tgtagaagg  tactttctg  accccactg  720
gctggagct  ctcgtggat  atgggagca  agatgctgg  cactgggcc  tggagcagg  780
gtggtacaa  gggaagttc  atgggagcc  agaggaact  gctcggaag  atgcagatg  840
agaggtgga  gtggtggtc  tggaggacc  gctgcctgg  ggcaagggg  atgacagca  900
agaggagcc  cccctcttc  cctcccaca  gccccgcgg  gacttcccc  gccccatcc  960
tgtgagcgg  ccccgcttg  tccagcccc  cggccctcg  ttcaggctg  agggcaacg  1020
tgtgctcta  ggcggctgg  gctttgcct  ccggctgcg  tcctccttc  ggctgcagg  1080
cctgaacgt  cacttcggc  gagagcgca  tgcctatga  gtcagcgtg  aagaggcag  1140
ggcgctgta  ggaggacac  cacctgcag  catgcagac  aagtacctc  atgtcggct  1200
gggcctggg  agcgtcact  atgagttag  ccccggcat  gactgcccg  agaccgcca  1260
cttcctgga  actttccac  actatgatg  cgatgaccc  gtccattat  cccgagccc  1320
ctgcctctt  gaaatgccc  caggggtgc  ccttcggcg  cactttaat  ccaacttta  1380
aggtggctt  aacttctat  cggggctga  gggccaggt  ctggtgctg  ggacaactt  1440
aactgtcta  aattatgat  acatttggg  ctttatctt  taccccaac  gggtgatgg  1500
ggccaagat  catgccact  gctacgtcc  cgccacctt  tacaccccc  aggggctgc  1560
ccacggcac  cgcctgcac  cccacctga  tggcaacat  cacactcac  tggtgcact  1620
ccgcgtaga  ctggatgtg  caggcacca  gaacagctt  cagacactg  agatgaagc  1680
agaaaacat  accaacccc  ggagcccga  acaccgcgt  gtccagcca  ctctggagc  1740
gacgcagta  tcctgggag  gccaggcgg  cttccgctt  aaaaggaag  tgcctaagt  1800
cctgctctt  accagcccc  aggagaacc  ctggggcca  aagcgcagc  accgcctgc  1860
gatccactc  atggccgac  aggtgctgc  cccaggctg  caggaggag  aggccatca  1920
ctgggcaag  actgagggg  gccagccca  ggccctgag  caagctcgt  cgcctgtgc  1980
tggcaggta  cccctggca  tgaccaagt  ccgggagtc  gagctgtgc  gcagcagca  2040
ctaccacca  aacgacccc  gggacccgc  cgtggtctt  gagcagttt  ttcacaaca  2100
cgagaacat  gaaaatgag  acctggtgg  ctgggtgac  gtgggcttc  tgcacatcc  2160
ccactcaga  gacattccc  acacagcca  acctgggaa  tccgtgggc  tcctgctcc  2220
gccattcaa  ttcttccca  aggacccct  cctggcatc  agagacact  tgatcgtgt  2280
gcctcggga  aacggcccc  actacgtcc  gcgctggat  cctgaggac  gggactgct  2340
gatgcctcc  ccttttagc  acaatggga  ctatagacc  gtgtgacca  cccccagtt  2400
ctcccccag  tcctcccag  aagcccagg  gcctcactg  ggcagacaa  aaaccctca  2460
agcctcaaa  aaa  2473



<210> 10003
<211> 751
<212> PRT
<213> Homo sapiens
<308> P19801
<400> 10003

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
  1               5                  10                  15
Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
             20                  25                  30
Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
         35                  40                  45
Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
     50                  55                  60
Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
 65                  70                  75                  80
His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                 85                  90                  95
Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
             100                105                110
Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
         115                120                125
Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
     130                135                140
Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
 145                150                155                160
Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                 165                170                175
Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
             180                185                190
Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
         195                200                205
Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
     210                215                220
Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
 225                230                235                240
Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                 245                250                255
Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
             260                265                270
His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
         275                280                285
Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
     290                295                300
Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
 305                310                315                320
Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                 325                330                335
Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
             340                345                350
Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
         355                360                365
Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
     370                375                380
Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
 385                390                395                400
Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                 405                410                415
Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
             420                425                430
Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
         435                440                445
Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
     450                455                460
Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
 465                470                475                480
Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                 485                490                495
His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
             500                505                510
Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
         515                520                525
Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
     530                535                540
Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
 545                550                555                560
Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Lys Tyr 
                 565                570                575
Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser 
             580                585                590
Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
         595                600                605
Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
     610                615                620
Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
 625                630                635                640
Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                 645                650                655
Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
             660                665                670
Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
         675                680                685
Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
     690                695                700
Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
 705                710                715                720
Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                 725                730                735
Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
             740                745                750



<210> 10004
<211> 3765
<212> DNA
<213> Rattus norvegicus
<308> X74226
<400> 10004

cctgacact  ggagcacgg  gccgcagga  tcggagtcc  tcgcccaca  tcggggagt  60
tctggcacc  cgcaagggc  gcttcagtg  caggctaag  ccagcctac  gtctgggct  120
tcttactgg  gcttcacct  gccagagcc  ccatgctca  aggaagctt  ccagtgggg  180
cttgcgggt  cccatccca  gggagagga  aaatagcat  acggagatc  gcgacaatg  240
ggacgatct  ctggagtac  acaggcggc  gcgccaaga  cggctccgg  agcaggaga  300
ggagaaggc  ggaacgcca  cgcctggag  ccatcctga  cctgtgtgc  gagtacagc  360
gagctgacg  gggacctga  actggggaa  tgcccagta  aggagaggc  acggcagca  420
tggctttgg  aggcaggag  ccctcaaga  gcttggcag  agccatagt  gtgtctgga  480
ggagtggcg  ggagtctgg  ggtgcctcg  agcgcctgt  ggagagcat  gagcgctct  540
atgaagaga  tctcaaaga  gagtgcagc  gcacagaga  cacccagca  gagcacgaa  600
atgctccta  cacgaagct  caaggagag  tgctggctg  ggaagagga  cgggctcag  660
ttctggggc  cgtagagca  ctgaaggtc  gagtgaagg  gctggaaca  cagctgcag  720
aggcagccc  agaggctga  atggagaga  cactgctgc  gggggagag  gaggcggag  780
gagcattgc  gcagaagga  caaagagct  tggaccagc  gcaggagaa  ttggtggcc  840
tggagacag  catccagaa  gagagggac  aggaggcag  cgctctaga  actgagaca  900
agctctttg  ggacctgga  ttccagcag  tggagcggg  gagtcgcgt  gaggaggag  960
gggagttgg  cggccaagg  ctgcttcgc  gcaaggctg  gttgctgcg  agcgtgagc  1020
agagaaagg  gcgcctagc  gtactggac  gtcaggctg  gcagatccg  gcccaagca  1080
tacaggagt  agagcgtct  gcccgggaa  agaatgctg  cctgcagct  ctgcaaaag  1140
agaaggaga  gctgactgt  cttgagagg  gatatcatt  gctcacggg  ggcaggcct  1200
ttccgaaga  cacctcaac  ctcaaagag  tttaccgct  caagatgaa  ggtgacatg  1260
ccagccccc  gcccaggac  cgtagtggc  ctctcccct  ctcctcagg  tcctcatcc  1320
cttcttcac  gctcagcgt  gctaccctg  gccgtagtc  ttccccaaa  agtgccctg  1380
tcgcccaga  tggcaccag  agtctccct  gaaacctgg  agccacgct  caggacatt  1440
agaccaagc  ccagctggc  ctacagcaa  aggtcgagt  acctcctgc  gagcccctc  1500
cacccgaag  cccagcagg  caccaagtg  tcgaggagc  acggcgacg  ctggctgag  1560
tgaagcaga  agcagcggc  gaggctcag  gccagtggg  tgccttgca  ggtgcagcc  1620
cctttccag  aggcccgtc  ggcttcccc  cgctcatgc  ccattctat  ctgcaccac  1680
tgccagcag  cagggaacg  ggagaggag  gcgagcacg  ttacgacac  ctgagcctg  1740
agagttcgg  cagcatgga  accagcatc  ctacggggg  caactccgc  tgttcccct  1800
acaacatgt  cagcgctag  ggtctggac  tgggcaaga  agaggaaat  gagaagatg  1860
taaaggaag  tcacgcgga  aagagccgg  tcatggagt  cagggagcg  gagatggag  1920
tacggaggc  ggccctgga  gaggaacgt  ggaggcggg  gcaagtgga  cggaggctg  1980
agagtgaga  cgcccgcag  cagcagctg  tggagaaag  agtcaagct  agggagaag  2040
agttttccc  ggctcgacc  ctgacacgt  atcttccca  ccggaagga  gactttgat  2100
tgaagaccc  catagagtc  tcaggccat  gggtggaca  ctgcctaca  gtggtgctt  2160
gcagcaagg  ctgccgtgg  tacttaatc  agatgggtg  caagattaa  tcgtggaag  2220
agcgctggt  tgtctttga  cggctgaag  gcacccttt  ctactatgt  gacaaacac  2280
agacgaagc  gaagggggt  atctacttc  aggccatcg  ggaagtgta  tatgaccac  2340
tgcgcagcg  agccaagag  ccgaatcca  ccctcacct  ctgtgtgaa  acccatgac  2400
ggctgtact  catggtggc  ccatctgca  aggccatgc  catctggat  gatgtcatc  2460
tcacgggag  tgagggcta  actcaattc  tgaactaac  accaggcac  tcctgggtc  2520
cccaggtca  ccccaggac  ccatgccct  ccacttgct  ctctgcttg  ccctggaga  2580
agaggcaca  tgggcacgg  ccacaaagg  tcaggatgt  gttgagtac  ccagggctt  2640
tgtgcaaga  aacgaaatt  ttctatgag  agtttggtg  ttgggaatc  ggctccggt  2700
cctaaagag  cagcagaga  gaaaggaag  gggagaggc  ttgtcgcct  ctgggagtc  2760
agaagtgca  gattccctc  tgggtccag  aggctgaag  ggcatagct  agctgtgac  2820
ctcagctct  tcctggtac  cacttagcc  agcttactt  ctctctgta  aggacaaat  2880
atggtacca  aatctgcca  agatcccct  tctcatctc  tcccctcta  aggggtctg  2940
ggggtcctg  gcagagcca  gtgtagaac  ggggagagg  tcaggcctg  acttcccgc  3000
cccggtctg  ctccttctc  tcccacctc  cacttttca  tacttagct  aaggaccag  3060
gacctcaag  gtcattctc  aggtccagc  ccgtaatca  gttacaagc  catcatcct  3120
gtctccatg  tggctgctt  ctcaccatg  ttacacact  attgccatg  ccactctgt  3180
gctctgccc  ctgcttcgg  tgtgggcca  atgagggta  atgccaccc  tctctccaa  3240
ccaggcctg  gggcctgtc  catggtggg  ggagataga  ttcctcccg  ctgcagtgt  3300
tctccagcc  ccagcccag  cctctccct  ttactgtgc  ttgcttaga  ccagaaggg  3360
tgatgtcca  agatccaag  ccagagagc  gcatcactg  ggggagagg  agctaagag  3420
tctgccctc  cattctgac  ggactagtt  ccaataagg  acgagggtg  tagctcaga  3480
tgtctggaa  gaagcctga  ttgggagca  ggcgggcag  agcagaggc  ctgagctgt  3540
gtaacctcc  ttcagtttc  caaaggtga  gggaaagaa  gacagagga  caagtctcc  3600
gctggctgg  ctcagcctt  cgccttaac  ctaagccac  ttccctgcc  tccccagca  3660
tgggccctt  gttgctggg  ctggctggg  gttttgcag  atttgtaag  atttcagca  3720
aacaataaa  gcattttga  tatgtaaaa  aaaaaaaaa  aaaaa  3765



<210> 10005
<211> 781
<212> PRT
<213> Rattus norvegicus
<308> CAA52297
<400> 10005

Met Leu Lys Gly Ser Phe Pro Val Gly Thr Cys Gly Cys Pro Ser Gln 
  1               5                  10                  15
Gly Arg Gly Lys Ile Ala Ser Arg Arg Ser Ala Thr Met Arg Thr Ile 
             20                  25                  30
Ser Trp Ser Thr Thr Gly Gly Ser Ala Lys Ser Gly Ser Gly Ser Arg 
         35                  40                  45
Arg Trp Arg Arg Leu Glu Arg Gln Arg Leu Glu Thr Ile Leu Asn Leu 
     50                  55                  60
Cys Ala Glu Tyr Ser Arg Ala Asp Gly Gly Pro Glu Thr Gly Glu Leu 
 65                  70                  75                  80
Pro Ser Ile Gly Glu Ala Thr Ala Ala Leu Ala Leu Ala Gly Arg Arg 
                 85                  90                  95
Pro Ser Arg Gly Leu Ala Gly Ala Ile Val Val Ser Gly Arg Ser Gly 
             100                105                110
Glu Glu Ser Gly Gly Ala Ser Gln Arg Leu Trp Glu Ser Met Glu Arg 
         115                120                125
Ser Asp Glu Glu Asn Leu Lys Glu Glu Cys Ser Ser Thr Glu Ser Thr 
     130                135                140
Gln Gln Glu His Glu Asp Ala Pro Ser Thr Lys Leu Gln Gly Glu Val 
 145                150                155                160
Leu Ala Val Glu Glu Glu Arg Ala Gln Val Leu Gly Arg Val Glu Gln 
                 165                170                175
Leu Lys Val Arg Val Lys Glu Leu Glu Gln Gln Leu Gln Glu Ala Ala 
             180                185                190
Arg Glu Ala Glu Met Glu Arg Ala Leu Leu Gln Gly Glu Arg Glu Ala 
         195                200                205
Glu Arg Ala Leu Leu Gln Lys Glu Gln Arg Ala Met Asp Gln Leu Gln 
     210                215                220
Glu Lys Leu Val Ala Leu Glu Thr Gly Ile Gln Lys Glu Arg Asp Lys 
 225                230                235                240
Glu Ala Asp Ala Leu Glu Thr Glu Thr Lys Leu Phe Glu Asp Leu Glu 
                 245                250                255
Phe Gln Gln Leu Glu Arg Glu Ser Arg Val Glu Glu Glu Arg Glu Leu 
             260                265                270
Ala Gly Gln Gly Leu Leu Arg Ser Lys Ala Glu Leu Leu Arg Ser Val 
         275                280                285
Ser Lys Arg Lys Glu Arg Leu Ala Val Leu Asp Ser Gln Ala Gly Gln 
     290                295                300
Ile Arg Ala Gln Ala Val Gln Glu Ser Glu Arg Leu Ala Arg Glu Lys 
 305                310                315                320
Asn Ala Val Leu Gln Leu Leu Gln Lys Glu Lys Glu Lys Leu Thr Val 
                 325                330                335
Leu Glu Arg Arg Tyr His Ser Leu Thr Gly Gly Arg Pro Phe Pro Lys 
             340                345                350
Thr Thr Ser Thr Leu Lys Glu Val Tyr Arg Ser Lys Met Asn Gly Asp 
         355                360                365
Met Ala Ser Pro Leu Pro Arg Thr Arg Ser Gly Pro Leu Pro Ser Ser 
     370                375                380
Ser Gly Ser Ser Ser Ser Ser Ser Gln Leu Ser Val Ala Thr Leu Gly 
 385                390                395                400
Arg Ser Pro Ser Pro Lys Ser Ala Leu Leu Ala Gln Asn Gly Thr Ser 
                 405                410                415
Ser Leu Pro Arg Asn Leu Ala Ala Thr Leu Gln Asp Ile Glu Thr Lys 
             420                425                430
Arg Gln Leu Ala Leu Gln Gln Lys Val Glu Leu Pro Pro Ala Glu Pro 
         435                440                445
Leu Ser Pro Glu Asp Pro Ala Gly His Gln Val Ile Glu Glu Gln Arg 
     450                455                460
Arg Arg Leu Ala Glu Leu Lys Gln Lys Ala Ala Ala Glu Ala Gln Cys 
 465                470                475                480
Gln Trp Asp Ala Leu His Gly Ala Ala Ala Phe Pro Ala Gly Pro Ser 
                 485                490                495
Gly Phe Pro Thr Leu Met His His Ser Ile Leu His His Leu Pro Ala 
             500                505                510
Gly Arg Glu Arg Gly Glu Glu Gly Glu His Ala Tyr Asp Thr Leu Ser 
         515                520                525
Leu Glu Ser Ser Asp Ser Met Glu Thr Ser Ile Ser Thr Gly Gly Asn 
     530                535                540
Ser Ala Cys Ser Pro Asp Asn Met Ser Ser Ala Ser Gly Leu Asp Met 
 545                550                555                560
Gly Lys Ile Glu Glu Met Glu Lys Met Leu Lys Glu Ala His Ala Glu 
                 565                570                575
Lys Ser Arg Leu Met Glu Ser Arg Glu Arg Glu Met Glu Leu Arg Arg 
             580                585                590
Gln Ala Leu Glu Glu Glu Arg Arg Arg Arg Glu Gln Val Glu Arg Arg 
         595                600                605
Leu Gln Ser Glu Ser Ala Arg Arg Gln Gln Leu Val Glu Lys Glu Val 
     610                615                620
Lys Leu Arg Glu Lys Gln Phe Ser Gln Ala Arg Pro Leu Thr Arg Tyr 
 625                630                635                640
Leu Pro Asn Arg Lys Glu Asp Phe Asp Leu Lys Thr His Ile Glu Ser 
                 645                650                655
Ser Gly His Gly Val Asp Thr Cys Leu His Val Val Leu Ser Ser Lys 
             660                665                670
Val Cys Arg Gly Tyr Leu Ile Lys Met Gly Gly Lys Ile Lys Ser Trp 
         675                680                685
Lys Lys Arg Trp Phe Val Phe Asp Arg Leu Lys Arg Thr Leu Ser Tyr 
     690                695                700
Tyr Val Asp Lys His Glu Thr Lys Leu Lys Gly Val Ile Tyr Phe Gln 
 705                710                715                720
Ala Ile Glu Glu Val Tyr Tyr Asp His Leu Arg Ser Ala Ala Lys Ser 
                 725                730                735
Pro Asn Pro Ala Leu Thr Phe Cys Val Lys Thr His Asp Arg Leu Tyr 
             740                745                750
Tyr Met Val Ala Pro Ser Ala Glu Ala Met Arg Ile Trp Met Asp Val 
         755                760                765
Ile Val Thr Gly Ala Glu Gly Tyr Thr Gln Phe Met Asn 
     770                775                780



<210> 10006
<211> 5449
<212> DNA
<213> Homo sapiens
<308> AB014538
<400> 10006

cccacgcgt  cgaagcctg  ggccaccgc  accgagccg  gccaggcta  gggaccagt  60
tctccctgc  cccccccca  ctctaggag  tctggagcc  taggaccat  gacgctctc  120
ataggaacc  aataggccc  ggatgccag  cccagacca  ggtgcagaa  ggacccttg  180
acctgatcg  gacaggcaa  gggctgaaa  tgcaaacgg  caaacccca  ctggtgagc  240
tgggcagtg  gcgactcag  acagccatc  ccctcctgc  gctggagga  gggaggacg  300
tgattggct  tgcagccag  gacatctca  tacagggcc  aggcctggc  ccagagcac  360
gctacatcg  gaacctgcg  ggcaccctc  ccctctacc  ctgtggcaa  gcctgcact  420
ttgatgggc  ccctgtccg  cagcctacc  ggctcactc  gggctgcat  ttgtgcctg  480
gtcagtcca  cttccttcg  tttaaccac  cggctgaag  caagtggat  aaaagcatg  540
ttccagcag  gggccgagc  cctgggccc  cctacagcc  tgttcctgc  gaatcagaa  600
gtctggtaa  tgggaacca  accccacag  ctgcaacac  gggaccctc  gcctgtgcc  660
gccacagtt  cctggtgag  tctattgag  aggacctgc  agagatcat  gactcactg  720
tgctagagg  gcctggagc  gctggcaag  agcctgccg  aacctctcc  ctgtcaccg  780
tggctaatg  tgggcgcta  ctgctgtct  ccccaacca  ccccggcgc  atgtctgtg  840
gctccagct  tgagaacac  tctccagcc  tctctccac  ctcttcacc  gccagcagt  900
gaagctgtg  cagtcactc  cccagtggg  aagagccag  accttctgt  cccccgctg  960
tacctgccc  ttcctccag  taccatctg  ccctacagc  cccacagtc  cgcccaagt  1020
gtgctcgct  cgagagtcc  cggctgagc  ggaaagggg  ccatgagag  cctcccagc  1080
ctggcctcc  gggtctgct  acagacagc  ctgcagcta  tgtcttggc  gaggcccgg  1140
gagccactg  gagcccccg  ctgggtggg  agctgcctg  ggtggccat  agcctgagt  1200
aatacccag  ttctggtgc  ctcagtcaa  ccaccagca  tcctggcag  cccaagttt  1260
agcctccag  ccctgctcc  cgaaacaag  ttggcacac  ccaggaccg  cctcccagc  1320
ctttccgtg  gcctccagg  agtgagcgg  tgctaacaa  cagcccctc  cgccaactg  1380
tgggccgaa  attttcaga  gggttagcc  cccgtaccc  gcagcctcc  gagagtccc  1440
gcctgggcc  gcggggcct  gacagtatg  gagaactac  ccccttaag  ccatctctg  1500
cccggcgag  tctctcccc  ctgcccacc  ggaccaccc  agatcccaa  ctaaacagg  1560
aagtggcag  gagtcctcg  ccccggcgc  gggcagccc  tggggcttc  ccagaggac  1620
tctccctga  gctgggggc  cggggccgt  ggacacgga  cccctcacc  acactgggt  1680
agtctctgg  accccacaa  ggcagcttc  gtggcaggc  gagcccagc  tacagtctg  1740
gctctctta  tggggcttc  ccctgccag  gtccctgtg  ccagaggaa  ctctccagc  1800
gggacttgc  ggtgcctgt  acaagggag  ggaaaaata  catcacaga  atcagtgac  1860
atgaggacg  cctcctgga  taccaccgg  gacagcgcc  agagcggct  cgggagcag  1920
agatggaga  gctggaacg  cagcgcctg  agaccatcc  gaacctgtg  gccgaatac  1980
gccgggctg  tgggggacc  gaggctggg  agcttccca  cattgggga  gccaccgca  2040
cattggcac  ggcaggccg  aggccctca  gaggccttg  aggggcctc  gggcggagc  2100
gcgaggagc  tggcgttgc  acccaacgc  tatgggaga  tatggagcg  tcagatgag  2160
aaaatctca  ggaggagtg  agcagcact  agagcaccc  gcaggagca  gaagatgca  2220
ctagcacca  gctccaggg  gaggtgcta  ccctggaag  agagcgggc  caggtgctg  2280
ggcacgtgg  gcagctcaa  gtccgtgtg  aggagctag  gcagcagct  caggagtca  2340
cccgagagg  cgaaatgga  cgggcactg  tgcagggag  gagggaggc  gagcgggca  2400
tgctgcaga  ggagcagaa  gcagtggat  agctgcagg  gaagctggt  gccttggag  2460
caggcatcc  gaaggagag  gacaaggag  cagaggccc  ggagactga  acaaagctc  2520
ttgaggact  ggagttcca  cagttggag  gggagagcc  cgtggagga  gagcgcgag  2580
tggccggcc  ggggctgct  cggagcaag  ctgagctgc  ccgcagcat  gccaagagg  2640
aggagcgcc  ggccatcct  gacagtcag  ctgggcaga  ccgggctca  gccgtgcag  2700
agtcagaac  cctggcccg  gacaagaat  cctccttac  gctgctgca  aaggagaag  2760
agaagctga  tgtgctgga  aggagatac  actcactca  agggggcag  cctttcccg  2820
agaccacat  gaccctcaa  gagatggag  agctgctgc  ccctgctgt  gacttagag  2880
agtggtacc  ggagctgat  gccgggctg  ggactggcc  cgctgcagc  tcccctcac  2940
cttctcccc  gcctctgcc  gccaaagct  cccgtcagc  gcaggttta  cgctccaag  3000
tggatggcg  ggccaccag  ccccttccc  ggacccgca  cggccccct  ccctcctcc  3060
ctggctctt  ctcctcctc  tcccagctc  gcgtggcta  cctggggcg  agcccctcc  3120
caaagagcg  tctactcac  cagaatggc  cgggcagcc  tcctcgcaa  ctggcagcc  3180
cactgcagg  catcgagac  aagcgccaa  tagctctgc  gcagaaggg  caacaagtg  3240
ttgaagagc  gcggcggcg  ctggctgag  tgaagcaga  agcggcagc  gaggcacag  3300
gccagtggg  tgcccttca  ggggcagca  ccttcccag  gggcccctc  ggcttcccc  3360
ctctcatgc  ccactctat  ctacaccac  tgcctgcgg  gcgggagcg  ggggaggag  3420
gtgagcacg  ctatgatac  ctgagtctg  agagctctg  cagcatgga  accagcatc  3480
ccaccgggg  caactcggc  tgctcccct  acaacatgt  cagcgcgag  ggtctggac  3540
tggggaaga  cgaggagat  gagaagatg  tgaaagagg  tcatgcaga  aagaaccgg  3600
tcatggagt  gagggagcg  gagatggag  tgcggcggc  ggccctgga  gaggagcgg  3660
ggaggcgtg  gcaggtaga  cggaggctg  agagtgaga  tgcccggag  cagcagctg  3720
tcgagaagg  ggtcaagat  cgggagaaa  aattttccc  ggcacgacc  ctgacccgc  3780
acctgccaa  ccggaagga  gactttgac  tgaagacac  tattgagtc  tcgggccat  3840
gtgttgata  ctgcctgca  gtggtgctc  gcagcaagg  ctgccgtgg  tacttggtc  3900
agatgggcg  caagattaa  tcatggaag  agcgctggt  tgtcttcga  cggctcaag  3960
gcacccttt  ctattatgt  gacaagcat  agacgaagc  gaagggagt  atctatttc  4020
aggccattg  ggaagtgta  tacgaccac  tgcgcagtg  agccaagaa  aggtttttc  4080
gcttcacta  ggtgactga  agcccgaac  cagccctca  cttctgcgt  aagacccat  4140
accggctgt  ctacatggt  gccccatct  cagaggcca  gcgtatctg  atggatgtc  4200
ttgtcacag  ggctgaggg  tacactcag  tcatgaact  actgtcgtg  gcctcctgg  4260
agagcacaa  tggggcttt  gtataagaa  actttaata  tctgtaagg  gcttggtcc  4320
gtgagtttc  gggctctgg  ctcctgaag  accagccag  agaagaaaa  tagaggtgg  4380
tttgctgcc  cctgggagc  cagaacttg  agtaaccct  tagggtcct  ccccaggcc  4440
agccagggc  gaggagctg  cacagagag  gcctcagct  tgacctgac  cctgctctc  4500
ccagcctgt  ttctctttt  taaaagaca  attatggta  cataagctg  caaagatcc  4560
ctcctgcct  agacccctt  gccaggggc  ttgggggct  agcagagcc  catccagag  4620
ggggtaata  ctcaggcgg  ccgcttccc  tttctcaaa  cccgctctg  cccattgtt  4680
tcctttccc  tatactttt  attaccttg  tcaagggcc  gagatctca  gtgtcaacc  4740
tgaggtccc  gctccatcc  ctagttgca  actcatcac  atggttacc  tagtgactg  4800
ttcattgcc  tggttacat  ctaattgct  cagctctgt  gcccagccc  ctgcttcag  4860
tgtgggcca  ctgagggta  gtgccatca  ctctccagc  caggcccct  ggcatctca  4920
gctgggggg  agggactga  taccttttt  cttccccct  cctgtgtct  cagccctga  4980
gcacaggct  ccagccccc  agtccagcc  tctcccttc  actggtgcc  tgcttagag  5040
cagaaggga  gaagccggg  gatctatgg  acagaggag  agcgatgca  ttgggagag  5100
aagctagaa  ggttatggt  ggagttctg  acagtgttg  gtttccgac  gggaaagag  5160
attcctcca  tgcgcctag  gagaaagcc  gagcaggag  tgatgcagc  gaggggaag  5220
gccctgtgg  gccgccgcc  ttccttcag  ctccgaagg  tgatggaaa  ggagagtgg  5280
ggaccaggc  tccagctgt  tggcctcgc  cttcacgcc  taacactaa  cccacctcc  5340
ctgctctcc  tcccagcat  gagcccttg  ttgcctggg  ccaggctgg  ggttttcag  5400
atttgtaag  atttcagca  aacaataaa  cctttggac  acggaagtg  5449



<210> 10007
<211> 402
<212> PRT
<213> Homo sapiens
<308> BAB55164
<400> 10007

Met Asp Gly Glu Ala Thr Ser Pro Leu Pro Arg Thr Arg Ser Gly Pro 
  1               5                  10                  15
Leu Pro Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gln Leu Ser Val 
             20                  25                  30
Ala Thr Leu Gly Arg Ser Pro Ser Pro Lys Ser Ala Leu Leu Thr Gln 
         35                  40                  45
Asn Gly Thr Gly Ser Leu Pro Arg Asn Leu Ala Ala Thr Leu Gln Asp 
     50                  55                  60
Ile Glu Thr Lys Arg Gln Leu Ala Leu Gln Gln Lys Gly Gln Gln Val 
 65                  70                  75                  80
Ile Glu Glu Gln Arg Arg Arg Leu Ala Glu Leu Lys Gln Lys Ala Ala 
                 85                  90                  95
Ala Glu Ala Gln Cys Gln Trp Asp Ala Leu His Gly Ala Ala Pro Phe 
             100                105                110
Pro Ala Gly Pro Ser Gly Phe Pro Pro Leu Met His His Ser Ile Leu 
         115                120                125
His His Leu Pro Ala Gly Arg Glu Arg Gly Glu Glu Gly Glu His Ala 
     130                135                140
Tyr Asp Thr Leu Ser Leu Glu Ser Ser Asp Ser Met Glu Thr Ser Ile 
 145                150                155                160
Ser Thr Gly Gly Asn Ser Ala Cys Ser Pro Asp Asn Met Ser Ser Ala 
                 165                170                175
Ser Gly Leu Asp Met Gly Lys Ile Glu Glu Met Glu Lys Met Leu Lys 
             180                185                190
Glu Ala His Ala Glu Lys Asn Arg Leu Met Glu Ser Arg Glu Arg Glu 
         195                200                205
Met Glu Leu Arg Arg Gln Ala Leu Glu Glu Glu Arg Arg Arg Arg Glu 
     210                215                220
Gln Val Glu Arg Arg Leu Gln Ser Glu Ser Ala Arg Arg Gln Gln Leu 
 225                230                235                240
Val Glu Lys Glu Val Lys Met Arg Glu Lys Gln Phe Ser Gln Ala Arg 
                 245                250                255
Pro Leu Thr Arg Tyr Leu Pro Ile Arg Lys Glu Asp Phe Asp Leu Lys 
             260                265                270
Thr His Ile Glu Ser Ser Gly His Gly Val Asp Thr Cys Leu His Val 
         275                280                285
Val Leu Ser Ser Lys Val Cys Arg Gly Tyr Leu Val Lys Met Gly Gly 
     290                295                300
Lys Ile Lys Ser Trp Lys Lys Arg Trp Phe Val Phe Asp Arg Leu Lys 
 305                310                315                320
Arg Thr Leu Ser Tyr Tyr Val Asp Lys His Glu Thr Lys Leu Lys Gly 
                 325                330                335
Val Ile Tyr Phe Gln Ala Ile Glu Glu Val Tyr Tyr Asp His Leu Arg 
             340                345                350
Ser Ala Ala Lys Ser Pro Asn Pro Ala Leu Thr Phe Cys Val Lys Thr 
         355                360                365
His Asp Arg Leu Tyr Tyr Met Val Ala Pro Ser Ala Glu Ala Met Arg 
     370                375                380
Ile Trp Met Asp Val Ile Val Thr Gly Ala Glu Gly Tyr Thr Gln Phe 
 385                390                395                400
Met Asn 
                 405



<210> 10008
<211> 1401
<212> DNA
<213> Rattus norvegicus
<308> X74402
<400> 10008

aagagcggg  gctggtacc  aggcctgac  atggatgag  aatacgatg  gattgtgct  60
gggacaggt  ttaccgaat  catcctgtc  ggcatcatg  ctgtgaatg  aaagaaggt  120
ttgcacatg  accgaaacc  ctactatgg  ggtgagagc  cttctatca  accccttga  180
gagctatat  agcgctttc  gttgctgga  gggccccct  aatcaatgg  ccggggccg  240
gactggaat  ttgacttga  ccccaaatt  ctcatggcc  atggtcagc  ggtaaagat  300
ctactgtat  cagaagtga  tcgttatct  gacttcaag  tggtagagg  cagctttgt  360
tacaaaggg  gcaagatct  caaagtgcc  tctactgag  ctgaggcct  ggcttctaa  420
ctgatgggc  tgtttgaaa  acgacgctt  cgaaaattt  tggtgtttg  ggcaaactt  480
gatgagaat  accccaaaa  ctttgaggg  gttgacccg  agaccacca  catgcgtga  540
gtctaccgg  agtttgacc  gggccaaga  gtcattgat  tcactggcc  tgccctggc  600
ctctaccgc  ctgatgatt  cctggttca  ccatgtctt  agactatta  ccgcatcaa  660
ttgtacagt  agtccctgg  ccggtatgg  aagagccca  atttgtacc  actctatgg  720
ctgggtgag  tgcctcagg  ctttgccag  ttgagtgcc  tctatgggg  aacatacat  780
ctgaacaaa  cagtggatg  catcatcat  gaaaatggc  aggtggtgg  tgtaaaatc  840
gagggagag  tggcccgct  caagcagct  atctgtgat  ccagctaca  cccagaccg  900
gtgcgaaag  ctggccagg  tattcgcat  atctgcatc  tcagccacc  catcaagaa  960
accaatgat  ccaattcct  ccaaattat  atccctcag  atcaggtca  caggaagtc  1020
gacatctat  tgtgcatga  ctcctatgc  cacaacgtg  ccgcacaag  caaatacat  1080
gccattgcc  gcaccaccg  agagactgc  gaaccagaa  aggaggttg  gcctgcatt  1140
gagctgttg  aacctattg  ccaaaagtt  gtggctatc  gtgatttat  tgagcccat  1200
gatgacggt  cagagagtc  ggtgttctg  tcctgctcc  atgatgcta  cacacactt  1260
gagacaacc  gcaatgaca  caaagatat  tacaaacgc  tggctggtt  tgcctttga  1320
tttgagaac  tgaagcgca  acagaatga  gtctttgga  aagccgatc  gtgattgct  1380
actcccctc  tccagcccc  g  1401



<210> 10009
<211> 447
<212> PRT
<213> Rattus norvegicus
<308> P50398
<400> 10009

Met Asp Glu Glu Tyr Asp Val Ile Val Leu Gly Thr Gly Leu Thr Glu 
  1               5                  10                  15
Cys Ile Leu Ser Gly Ile Met Ser Val Asn Gly Lys Lys Val Leu His 
             20                  25                  30
Met Asp Arg Asn Pro Tyr Tyr Gly Gly Glu Ser Ser Ser Ile Thr Pro 
         35                  40                  45
Leu Glu Glu Leu Tyr Lys Arg Phe Gln Leu Leu Glu Gly Pro Pro Glu 
     50                  55                  60
Ser Met Gly Arg Gly Arg Asp Trp Asn Val Asp Leu Ile Pro Lys Phe 
 65                  70                  75                  80
Leu Met Ala Asn Gly Gln Leu Val Lys Met Leu Leu Tyr Thr Glu Val 
                 85                  90                  95
Thr Arg Tyr Leu Asp Phe Lys Val Val Glu Gly Ser Phe Val Tyr Lys 
             100                105                110
Gly Gly Lys Ile Tyr Lys Val Pro Ser Thr Glu Thr Glu Ala Leu Ala 
         115                120                125
Ser Asn Leu Met Gly Met Phe Glu Lys Arg Arg Phe Arg Lys Phe Leu 
     130                135                140
Val Phe Val Ala Asn Phe Asp Glu Asn Asp Pro Lys Thr Phe Glu Gly 
 145                150                155                160
Val Asp Pro Gln Thr Thr Ser Met Arg Asp Val Tyr Arg Lys Phe Asp 
                 165                170                175
Leu Gly Gln Asp Val Ile Asp Phe Thr Gly His Ala Leu Ala Leu Tyr 
             180                185                190
Arg Thr Asp Asp Tyr Leu Asp Gln Pro Cys Leu Glu Thr Ile Asn Arg 
         195                200                205
Ile Lys Leu Tyr Ser Glu Ser Leu Ala Arg Tyr Gly Lys Ser Pro Tyr 
     210                215                220
Leu Tyr Pro Leu Tyr Gly Leu Gly Glu Leu Pro Gln Gly Phe Ala Arg 
 225                230                235                240
Leu Ser Ala Ile Tyr Gly Gly Thr Tyr Met Leu Asn Lys Pro Val Asp 
                 245                250                255
Asp Ile Ile Met Glu Asn Gly Lys Val Val Gly Val Lys Ser Glu Gly 
             260                265                270
Glu Val Ala Arg Cys Lys Gln Leu Ile Cys Asp Pro Ser Tyr Ile Pro 
         275                280                285
Asp Arg Val Arg Lys Ala Gly Gln Val Ile Arg Ile Ile Cys Ile Leu 
     290                295                300
Ser His Pro Ile Lys Asn Thr Asn Asp Ala Asn Ser Cys Gln Ile Ile 
 305                310                315                320
Ile Pro Gln Asn Gln Val Asn Arg Lys Ser Asp Ile Tyr Val Cys Met 
                 325                330                335
Ile Ser Tyr Ala His Asn Val Ala Ala Gln Gly Lys Tyr Ile Ala Ile 
             340                345                350
Ala Ser Thr Thr Val Glu Thr Ala Glu Pro Glu Lys Glu Val Glu Pro 
         355                360                365
Ala Leu Glu Leu Leu Glu Pro Ile Asp Gln Lys Phe Val Ala Ile Ser 
     370                375                380
Asp Leu Tyr Glu Pro Ile Asp Asp Gly Ser Glu Ser Gln Val Phe Cys 
 385                390                395                400
Ser Cys Ser Tyr Asp Ala Thr Thr His Phe Glu Thr Thr Cys Asn Asp 
                 405                410                415
Ile Lys Asp Ile Tyr Lys Arg Met Ala Gly Ser Ala Phe Asp Phe Glu 
             420                425                430
Asn Met Lys Arg Lys Gln Asn Asp Val Phe Gly Glu Ala Asp Gln 
         435                440                445



<210> 10010
<211> 2225
<212> DNA
<213> Homo sapiens
<308> X79353
<400> 10010

cggcggcgg  ggtggcggc  gcgactgct  cggtgaagg  ggaggagga  ccgagcggg  60
gctggcacc  aggcctgac  atggacgag  aatacgatg  gatcgtgct  gggaccggt  120
tcaccgaat  catcctgtc  ggcatcatg  ctgtgaacg  gaagaaggt  ctgcacatg  180
accggaacc  ctactacgg  ggcgagagc  cctccatca  acccctgga  gagctgtat  240
agcgttttc  gttgctgga  gggccccct  agtcgatgg  ccgaggccg  gactggaat  300
ttgacctga  tcccaaatt  ctcatggct  acgggcagc  ggtaaagat  ctactgtat  360
cagaggtga  tcgctacct  gacttcaag  tggtggagg  cagctttgt  tacaagggg  420
gcaagatct  caaagtgcc  tccactgag  ctgaggcct  ggcttccaa  ctgatgggc  480
tgtttgaga  acggcgctt  cgcaagttc  tggtgtttg  ggcaaactt  gatgagaat  540
accccaaga  ctttgaggg  gttgacccc  agactacca  catgcgtga  gtctaccgg  600
agtttgatc  gggccagga  gtcatcgat  tcactggcc  tgccctggc  ctctaccgc  660
ctgatgact  cctggacca  ccctgcctt  agaccgtca  ccgcatcaa  ttgtacagt  720
agtccctgg  ccggtatgg  aagagccca  atttatacc  gctctacgg  ttgggcgag  780
tgccccagg  ttttgcaag  ttgagtgcc  tctatgggg  gacatatat  ctgaacaaa  840
ctgtggatg  catcatcat  gagaacggc  aggtggtgg  cgtgaagtc  gagggagag  900
tggcccgct  caagcagct  atctgtgac  ccagctaca  cccggaccg  gtgcggaag  960
ctggccagg  tatccgcat  atctgtatc  ttagccacc  catcaagaa  accaacgac  1020
ccaactcct  ccaaataat  atcccccag  accaggtca  caggaagtc  gacatctac  1080
tgtgcatga  ctcctatgc  cacaacgtg  cggcccagg  caagtacat  gctattgcc  1140
gcactactg  ggagaccac  gaccctgaa  aggaggtgg  gccggctct  gagctgttg  1200
agcccattg  ccagaagtt  gtggctatc  gtgacttgt  tgagcccat  gatgatggt  1260
gtgagagcc  ggtgttctg  tcctgctcc  acgatgcca  cacacactt  gagacaacc  1320
gcaacgaca  caaagacat  tacaaacgc  tggctggca  ggcctttga  tttgagaac  1380
tgaagcgca  acagaacga  gtctttgga  aagctgagc  gtgattgtg  ccgccccca  1440
cccctgctg  cccagcctg  gtctgttct  ctcgagggc  ccagcatcc  ctgcttccc  1500
caccacgtt  ccatcaccc  cctcattga  ccactgacc  aatccttaa  cctagcgat  1560
gcttgggag  tggggggtt  gatagcatc  tctttcttg  cccttcctt  tcctaggaa  1620
agagggttc  tctccttgt  tgtgtctct  ccccccacc  ctaattctt  tgctctgtt  1680
gggaagacg  ggaggaaaa  gtgacttct  cccccaccg  tcttacccc  actgtagtg  1740
cctttggag  tgcccccac  tccccccca  caactctcg  gtgttggag  gaaggggcc  1800
tcccagcac  aagttgcat  cctcccccc  taatttatt  taatttatt  actttgacc  1860
accctttct  agcctgcag  cttcccgtg  ggcctgagg  ctgtcgagt  agctgcccc  1920
gccccctcc  agcccttgc  cagcctggg  gagtgggga  ggcttgggc  tggccccgt  1980
ggaggttga  ttgctgttt  gtttcttgt  tttgtgttc  gtggtactt  ctgagagaa  2040
agaaaagtg  gccaagcag  aggaggtgg  aaacggacc  aaaccccag  gtgccctgc  2100
ccatgcctt  cctttagtg  tgggaaacc  ttatcttgc  aagtgaatg  gtccccttc  2160
ccaccctct  gtgtatttc  cagaaaaca  aacctccca  taaaacggt  gaaacctga  2220
aaaaa  2225



<210> 10011
<211> 447
<212> PRT
<213> Homo sapiens
<308> P31150
<400> 10011

Met Asp Glu Glu Tyr Asp Val Ile Val Leu Gly Thr Gly Leu Thr Glu 
  1               5                  10                  15
Cys Ile Leu Ser Gly Ile Met Ser Val Asn Gly Lys Lys Val Leu His 
             20                  25                  30
Met Asp Arg Asn Pro Tyr Tyr Gly Gly Glu Ser Ser Ser Ile Thr Pro 
         35                  40                  45
Leu Glu Glu Leu Tyr Lys Arg Phe Gln Leu Leu Glu Gly Pro Pro Glu 
     50                  55                  60
Ser Met Gly Arg Gly Arg Asp Trp Asn Val Asp Leu Ile Pro Lys Phe 
 65                  70                  75                  80
Leu Met Ala Asn Gly Gln Leu Val Lys Met Leu Leu Tyr Thr Glu Val 
                 85                  90                  95
Thr Arg Tyr Leu Asp Phe Lys Val Val Glu Gly Ser Phe Val Tyr Lys 
             100                105                110
Gly Gly Lys Ile Tyr Lys Val Pro Ser Thr Glu Thr Glu Ala Leu Ala 
         115                120                125
Ser Asn Leu Met Gly Met Phe Glu Lys Arg Arg Phe Arg Lys Phe Leu 
     130                135                140
Val Phe Val Ala Asn Phe Asp Glu Asn Asp Pro Lys Thr Phe Glu Gly 
 145                150                155                160
Val Asp Pro Gln Thr Thr Ser Met Arg Asp Val Tyr Arg Lys Phe Asp 
                 165                170                175
Leu Gly Gln Asp Val Ile Asp Phe Thr Gly His Ala Leu Ala Leu Tyr 
             180                185                190
Arg Thr Asp Asp Tyr Leu Asp Gln Pro Cys Leu Glu Thr Val Asn Arg 
         195                200                205
Ile Lys Leu Tyr Ser Glu Ser Leu Ala Arg Tyr Gly Lys Ser Pro Tyr 
     210                215                220
Leu Tyr Pro Leu Tyr Gly Leu Gly Glu Leu Pro Gln Gly Phe Ala Arg 
 225                230                235                240
Leu Ser Ala Ile Tyr Gly Gly Thr Tyr Met Leu Asn Lys Pro Val Asp 
                 245                250                255
Asp Ile Ile Met Glu Asn Gly Lys Val Val Gly Val Lys Ser Glu Gly 
             260                265                270
Glu Val Ala Arg Cys Lys Gln Leu Ile Cys Asp Pro Ser Tyr Ile Pro 
         275                280                285
Asp Arg Val Arg Lys Ala Gly Gln Val Ile Arg Ile Ile Cys Ile Leu 
     290                295                300
Ser His Pro Ile Lys Asn Thr Asn Asp Ala Asn Ser Cys Gln Ile Ile 
 305                310                315                320
Ile Pro Gln Asn Gln Val Asn Arg Lys Ser Asp Ile Tyr Val Cys Met 
                 325                330                335
Ile Ser Tyr Ala His Asn Val Ala Ala Gln Gly Lys Tyr Ile Ala Ile 
             340                345                350
Ala Ser Thr Thr Val Glu Thr Thr Asp Pro Glu Lys Glu Val Glu Pro 
         355                360                365
Ala Leu Glu Leu Leu Glu Pro Ile Asp Gln Lys Phe Val Ala Ile Ser 
     370                375                380
Asp Leu Tyr Glu Pro Ile Asp Asp Gly Cys Glu Ser Gln Val Phe Cys 
 385                390                395                400
Ser Cys Ser Tyr Asp Ala Thr Thr His Phe Glu Thr Thr Cys Asn Asp 
                 405                410                415
Ile Lys Asp Ile Tyr Lys Arg Met Ala Gly Thr Ala Phe Asp Phe Glu 
             420                425                430
Asn Met Lys Arg Lys Gln Asn Asp Val Phe Gly Glu Ala Glu Gln 
         435                440                445



<210> 10012
<211> 2277
<212> DNA
<213> Rattus norvegicus
<308> X74593
<400> 10012

ccaccagcg  cagaattta  tattggaag  agtttgaga  agctcaggt  ttggccatg  60
tcttctcca  cagagtctt  tttttttca  gtgtcccct  actccagac  cttggcggt  120
tgacgagca  aaacaccag  tccccgccg  atccagccg  cacctcaaa  caagagagc  180
acatggcag  tcctgctaa  ggcgagaac  tgtccctgg  ggtgcacgg  cctggagac  240
ttcgcctgg  gaactaccc  atccctgag  tgggcccaa  tgatgtgtt  ctaaagatg  300
attcggtgg  gatctgtgg  tcggatgtt  actactggg  gcatggccg  attggggac  360
tcgttgtga  aaagccaat  gtgcttggg  atgaagctg  tggaacagt  acaaaagtg  420
gaccgatgg  gaaacatct  aaaccagga  atcgggtgg  catcgagcc  ggcgttccc  480
gagaaatag  tgaattctg  aagatcggc  gatacaatc  gacgccatc  atcttcttc  540
gtgccacgc  cccagatga  gggaacctc  gccgcttct  caagcacag  gctgacttc  600
gctacaagc  tcctgatag  gtcaccttt  aagaagggg  cctgattga  cctctctct  660
tggggatct  tgcctgccg  cgaggttcg  tttccctgg  gaacaaggt  cttgtgtgt  720
gagctgggc  aattgggat  gtcactttg  ttgtggcca  agcaatggg  gcttctcaa  780
tagtggtga  tgacctctc  gcttctcgg  tagccaagg  caaggaagt  ggagcagac  840
ttaccatcc  ggttgccaa  gagacccct  acgacattg  caagaaggt  gaaagtgtg  900
tggggagca  gccagaggt  accatcgaa  gcacgggag  ggagtcctc  gtccagacg  960
gcatctatg  cactcactc  ggcgggacc  tggtggttg  gggaatggg  cccgagatg  1020
tcaatttac  cctagtgca  gcagctgtg  gggaggtgg  catcaaagg  gtgtttcga  1080
actgcaaca  gtggccgat  gcagtttcc  tgcttgcat  gaagacttt  aatgtaaag  1140
ccttagtga  ccataggtt  cccctggag  aggctgtag  agcctttga  acagccaaa  1200
agggactgg  gctgaaagt  atgatcaag  gtgacccca  tgaccagaa  ccctaaatg  1260
gattgctct  tgcccttag  ccactctct  agcatctaa  ggctaaatg  accagaagg  1320
gaagccatt  atgcagaac  ttctttttg  atggtagga  taataaact  ataagccga  1380
agccttaga  gagctggcg  gccttaaag  cagaagtag  ggcaccttg  gggacctcg  1440
agccagaat  agatgcgta  actgagtaa  gtctagaac  aagagtctg  cagagaggt  1500
ccggaaatg  cctttctca  taccttctt  gggtgagga  acgaagcat  cttcgtcca  1560
gttccaatg  gggtgccag  gagtggggc  aacatggag  aatgacgtc  ttaacatgg  1620
agtggcccc  gagctgttc  gagcacagt  tttcccaag  gtcatttga  ttgagggga  1680
taagggcac  cagctctgc  tcagctcag  attctgtcc  tacatttgc  aagtggagg  1740
cttcttccc  acagtgctc  ttcatgttc  ggagcagta  cgttgctaa  caaccagga  1800
tcttccacc  aaagatcct  aatccagcc  aactcatac  agagggcca  aggagggct  1860
gagtttccc  ctcacagga  tcgcctcct  tcccaggct  actcctagg  aattattat  1920
ccatcccac  cagaagatg  tccccttct  ggctgttaa  gctagtgat  tctgatgga  1980
gggtatcac  gagcctaat  aaattatgg  gcttttctt  ataagatct  ggtccaaat  2040
atgcccttt  tgatcttaa  ataatcaag  agagcacag  aactgtggt  taacttggg  2100
tgcagtctg  aatccacct  ttcagctat  agtagggga  acgtgaaaa  aaaaagact  2160
tgctggaga  gaccatggc  aacacctga  ctttctcaa  ctgcttcca  tagtaaatt  2220
tgtcgctgg  gttgaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaag  2277



<210> 10013
<211> 399
<212> PRT
<213> Rattus norvegicus
<308> P27867
<400> 10013

Met Val Phe Ser Ser Arg Val Phe Phe Phe Ser Arg Val Pro Leu Leu 
  1               5                  10                  15
Gln Thr Leu Gly Gly Leu Thr Ser Arg Asn Thr Ser Ser Pro Pro Asp 
             20                  25                  30
Pro Ala Asp Thr Ser Lys Gln Glu Ser Asp Met Ala Ala Pro Ala Lys 
         35                  40                  45
Gly Glu Asn Leu Ser Leu Val Val His Gly Pro Gly Asp Ile Arg Leu 
     50                  55                  60
Glu Asn Tyr Pro Ile Pro Glu Leu Gly Pro Asn Asp Val Leu Leu Lys 
 65                  70                  75                  80
Met His Ser Val Gly Ile Cys Gly Ser Asp Val His Tyr Trp Glu His 
                 85                  90                  95
Gly Arg Ile Gly Asp Phe Val Val Lys Lys Pro Met Val Leu Gly His 
             100                105                110
Glu Ala Ala Gly Thr Val Thr Lys Val Gly Pro Met Val Lys His Leu 
         115                120                125
Lys Pro Gly Asp Arg Val Ala Ile Glu Pro Gly Val Pro Arg Glu Ile 
     130                135                140
Asp Glu Phe Cys Lys Ile Gly Arg Tyr Asn Leu Thr Pro Ser Ile Phe 
 145                150                155                160
Phe Cys Ala Thr Pro Pro Asp Asp Gly Asn Leu Cys Arg Phe Tyr Lys 
                 165                170                175
His Ser Ala Asp Phe Cys Tyr Lys Leu Pro Asp Ser Val Thr Phe Glu 
             180                185                190
Glu Gly Ala Leu Ile Glu Pro Leu Ser Val Gly Ile Tyr Ala Cys Arg 
         195                200                205
Arg Gly Ser Val Ser Leu Gly Asn Lys Val Leu Val Cys Gly Ala Gly 
     210                215                220
Pro Ile Gly Ile Val Thr Leu Leu Val Ala Lys Ala Met Gly Ala Ser 
 225                230                235                240
Gln Val Val Val Ile Asp Leu Ser Ala Ser Arg Leu Ala Lys Ala Lys 
                 245                250                255
Glu Val Gly Ala Asp Phe Thr Ile Gln Val Ala Lys Glu Thr Pro His 
             260                265                270
Asp Ile Ala Lys Lys Val Glu Ser Val Leu Gly Ser Lys Pro Glu Val 
         275                280                285
Thr Ile Glu Cys Thr Gly Ala Glu Ser Ser Val Gln Asp Gly Ile Tyr 
     290                295                300
Ala Thr His Ser Gly Gly Thr Leu Val Val Val Gly Met Gly Pro Glu 
 305                310                315                320
Met Ile Asn Leu Pro Leu Val His Ala Ala Val Arg Glu Val Asp Ile 
                 325                330                335
Lys Gly Val Phe Arg Tyr Cys Asn Thr Trp Pro Met Ala Val Ser Met 
             340                345                350
Leu Ala Ser Lys Thr Leu Asn Val Lys Pro Leu Val Thr His Arg Phe 
         355                360                365
Pro Leu Glu Lys Ala Val Glu Ala Phe Glu Thr Ala Lys Lys Gly Leu 
     370                375                380
Gly Leu Lys Val Met Ile Lys Cys Asp Pro Asn Asp Gln Asn Pro 
 385                390                395



<210> 10014
<211> 2519
<212> DNA
<213> Homo sapiens
<308> L29008
<400> 10014

agtcccgcc  ctgcgtgcg  cgcttctcc  aggccccac  ttccatcca  tgccctgga  60
cctcggctg  gtagcgcca  cagagcgac  aaacgtccc  cgccttcca  gccgcactc  120
agagccaaa  gagctccat  gcggcggcg  ccaagccca  caacctttc  ctggtggtg  180
acggaccgg  ggacttgcg  ctggagaac  atcctatcc  tgaaccagg  ccaaatgag  240
tcttgctga  gatgcattc  gttggaatc  gtggctcag  tgtccacta  tgggagtat  300
gtcgaattg  gaattttat  gtgaaaaag  ccatggtgc  gggacatga  gcttcggga  360
cagtcgaaa  agtgggatc  tcggtaaag  acctaaaac  aggtgatcg  gttgccatc  420
agcctggtg  tccccgaga  aatgatgaa  tctgcaaga  gggccgata  aatctgtca  480
cttccatct  cttctgtgc  acgcccccc  atgacggga  cctctgccg  ttctataag  540
acaatgcag  cttttgtta  aagcttcct  acaatgtca  ctttgagga  ggcgccctg  600
tcgagccac  ttctgtggg  atccatgcc  gcaggagag  cggagttac  ctgggacac  660
aggtccttg  gtgtggagc  gggccaatc  ggatggtca  tttgctcgt  gccaaagca  720
tgggagcag  tcaagtagt  gtgactgat  tgtctgcta  ccgattgtc  aaagccaag  780
agattgggg  tgatttagt  ctccagatc  ccaaggaga  ccctcagga  atcgccagg  840
aagtagaag  tctgctggg  tgcaagccg  aagtcacca  cgagtgcac  ggggcagag  900
cctccatcc  ggcgggcat  tacgccact  gctctggtg  gaccctcgt  cttgtgggg  960
tgggctctg  gatgaccac  gtaccccta  tgcatgcag  catccggga  gtggatatc  1020
agggcgtgt  tcgatactg  aacacgtgg  cagtggcga  ttcgatgct  gcgtccaag  1080
ctgtgaatg  aaaacccct  gtcacccat  ggtttcctc  ggagaaagc  ctggaggcc  1140
ttgaaacat  taaaaaggg  ttggggttg  aaatcatgc  caagtgtga  cccagtgac  1200
agaatccct  atgttaatg  gctctgctc  tccccacag  ctcgggatc  cagggcaca  1260
tggctggac  ggggtgggc  ctgatgcag  actttctct  ttgaatgtt  agaataact  1320
atacaattc  ttgtgaaca  aagtcctta  gcagaggaa  tggtgtgcc  taaagatac  1380
atctgggat  gtttggggg  acttgtagc  agaatgccc  gttcatgct  agcaaagtt  1440
agcaagtag  gcagagttt  gcaggcagg  gccaggaac  ccccttctt  ctggagtgc  1500
ttcattgag  aaggaaatc  ggcccttgg  tttcctggt  ccactgcta  tgacccaga  1560
gggaatgag  gctgagtta  gaaaagata  cttcatgaa  acttaactg  cccagaagc  1620
gattttcat  aaaatctgc  actcagggt  tgggatgaa  gcttgtcag  acttccagt  1680
tagaacgca  tgtttctag  gacatattg  ctgtttgtt  tgatgataa  aggagaata  1740
gaaaaggca  cactttcct  gatccagga  aatttttaa  ccaatcaaa  gaaaaaaac  1800
aacaaacaa  aaaggaaat  tcatgtgag  ttaaaccag  ttgcattcc  ctaatgtgg  1860
aaaagtaag  ggactactc  gcactgttt  aagattgcc  cttctacag  ttctgagaa  1920
tgtgttatt  cacttgcca  gtgaaggac  ccctcccca  catgcccca  cccacccct  1980
agcatggtc  cttgtcacc  ggcaaccag  aaactgcta  ttgtggacc  caccagaga  2040
caggagggt  tggttagct  acaggactt  ccccacccc  gaagattag  atcccatac  2100
agactcata  tcaactcaa  taggctcat  ctcaattga  ggttattag  caattccat  2160
tctttctgg  tattataaa  agaaaatct  tcctcttct  attaccagt  aaggctctt  2220
gtatctttc  gttggaatg  tttctatga  cttgtctta  tttaatggt  ggttttttt  2280
ctggtaaga  ttagaccta  atcgcatca  gccaacttg  gactttgag  ctattcatc  2340
agaatgagg  tatagtagc  atgacatag  ttgagctat  gcctttaat  ccttacttt  2400
gctatgggt  gagggtgag  ttgaagagg  tctgatttt  ttgtaacct  ggaaagcca  2460
gaccttgtg  ccgattctt  cagattgct  tgggtaata  atattggtg  tggtatctg  2519



<210> 10015
<211> 356
<212> PRT
<213> Homo sapiens
<308> Q00796
<400> 10015

Ala Ala Ala Ala Lys Pro Asn Asn Leu Ser Leu Val Val His Gly Pro 
  1               5                  10                  15
Gly Asp Leu Arg Leu Glu Asn Tyr Pro Ile Pro Glu Pro Gly Pro Asn 
             20                  25                  30
Glu Val Leu Leu Arg Met His Ser Val Gly Ile Cys Gly Ser Asp Val 
         35                  40                  45
His Tyr Trp Glu Tyr Gly Arg Ile Gly Asn Phe Ile Val Lys Lys Pro 
     50                  55                  60
Met Val Leu Gly His Glu Ala Ser Gly Thr Val Glu Lys Val Gly Ser 
 65                  70                  75                  80
Ser Val Lys His Leu Lys Pro Gly Asp Arg Val Ala Ile Glu Pro Gly 
                 85                  90                  95
Ala Pro Arg Glu Asn Asp Glu Phe Cys Lys Met Gly Arg Tyr Asn Leu 
             100                105                110
Ser Pro Ser Ile Phe Phe Cys Ala Thr Pro Pro Asp Asp Gly Asn Leu 
         115                120                125
Cys Arg Phe Tyr Lys His Asn Ala Ala Phe Cys Tyr Lys Leu Pro Asp 
     130                135                140
Asn Val Thr Phe Glu Glu Gly Ala Leu Ile Glu Pro Leu Ser Val Gly 
 145                150                155                160
Ile His Ala Cys Arg Arg Gly Gly Val Thr Leu Gly His Lys Val Leu 
                 165                170                175
Val Cys Gly Ala Gly Pro Ile Gly Met Val Thr Leu Leu Val Ala Lys 
             180                185                190
Ala Met Gly Ala Ala Gln Val Val Val Thr Asp Leu Ser Ala Thr Arg 
         195                200                205
Leu Ser Lys Ala Lys Glu Ile Gly Ala Asp Leu Val Leu Gln Ile Ser 
     210                215                220
Lys Glu Ser Pro Gln Glu Ile Ala Arg Lys Val Glu Gly Leu Leu Gly 
 225                230                235                240
Cys Lys Pro Glu Val Thr Ile Glu Cys Thr Gly Ala Glu Ala Ser Ile 
                 245                250                255
Gln Ala Gly Ile Tyr Ala Thr Arg Ser Gly Gly Thr Leu Val Leu Val 
             260                265                270
Gly Leu Gly Ser Glu Met Thr Thr Val Pro Leu Leu His Ala Ala Ile 
         275                280                285
Arg Glu Val Asp Ile Lys Gly Val Phe Arg Tyr Cys Asn Thr Trp Pro 
     290                295                300
Val Ala Ile Ser Met Leu Ala Ser Lys Ser Val Asn Val Lys Pro Leu 
 305                310                315                320
Val Thr His Arg Phe Pro Leu Glu Lys Ala Leu Glu Ala Phe Glu Thr 
                 325                330                335
Phe Lys Lys Gly Leu Gly Leu Lys Ile Met Leu Lys Cys Asp Pro Ser 
             340                345                350
Asp Gln Asn Pro 
         355



<210> 10016
<211> 3810
<212> DNA
<213> Rattus norvegicus
<308> X74800
<400> 10016

gatagactc  agcggaatc  acgccggag  tcccaaggc  cactcccac  cagcctggc  60
aggccggct  cagtgggat  caggggtcg  gactccgat  cccctaagc  aaagggcct  120
caaggggca  tgcgggggg  ggggctagc  cctccctcg  tgaccgtgc  ccggagcac  180
gattaacgc  ggcacggag  agggcacca  gtcgcagga  gcgctaccg  gcgtcggcc  240
tgggcagtg  cggggtacg  gtgaccatg  agagcgcct  gactgcccg  gaccgggtg  300
gggtgcaag  ctttgttct  ctggagaac  tcaccagtg  ggctgcctt  attgagaac  360
tccggcgtc  attccggga  aacctcatt  atacctaca  tggccctgt  ctggtctct  420
tcaacccct  ccgggacct  cagatctac  cacggcaac  tatggaacg  taccgtggc  480
tcagtttct  tgaagtgcc  cctcatctg  ttgcagtgg  tgacactgt  taccgggcg  540
ttcgtactg  gcgtcggga  caagcagtg  tgatttctg  agagagtgg  gcagggaag  600
cagaggcca  caagagatt  ctccagttc  atgcagaga  ctgcccagc  cctgaaagg  660
gtggcgcag  gcgagaccg  ctgttgcag  gcaaccctg  gctggaggc  tttgggaat  720
ccaagactc  ccgcaacga  aactccagc  gctttggga  gtacatgga  gtgcagttt  780
acttcaagg  tgcccctgt  ggaggccac  ttctcagtt  cctcctgga  aagtctcga  840
tggtacacc  gaatcacgg  gaacggaac  tccacgtct  ttaccagct  ctggagggg  900
gggaggagg  ggctcttcg  cgtctgggc  tggaacgga  cccccagag  tacttgtac  960
tggtgaagg  ccagtgtgc  aaggtctcc  ccatcaatg  caagagtga  tggaaggtt  1020
tgaggaagg  gctgtcagt  attgacttc  ctgaggatg  agtggagga  ttgctaagc  1080
tcgtggcca  cgtcctaca  ctgggcaat  tccactttg  tgctgatga  gacagcaat  1140
cccaggtta  tactgagaa  cagctcaaa  atctgacca  gctccttgg  gtggaaggc  1200
caacactga  ggaagccct  acccacagg  agatcatcg  caaggggga  gagctcctg  1260
gcccactga  ccttgaaca  gctgcatat  caagggatg  tcttgccaa  gctgtgtac  1320
gccgcactt  cacctggtt  gtcagaaag  tcaataggt  tctggcctc  aaggacgct  1380
agagcccca  ctggcgaag  accacagtt  ttgggctcc  ggacattta  ggcttcgaa  1440
tgtttcagc  taacagctt  gagcagttc  gcatcaact  ttgcaatga  aagctgcag  1500
agctcttca  tgagctgac  ctcaagtcc  agcaggagg  atacgaggc  gagggcatc  1560
cgtgggaac  tgtccaata  ttcaacaac  agatcatct  tgacctggt  gaggagaaa  1620
tcaagggca  catctccat  ttggatgaa  agtgcctgc  tcctgggga  gccacagac  1680
tgaccttcc  ggagaagct  gaggacaca  tcaagcacc  ccctcactt  ctgacgcac  1740
agcttgctg  ccagaagac  aggaaatcc  tcgaccgag  ggagttccg  cttcttcat  1800
atgcgggag  ggtgaccta  agcgtgact  ggtttctgg  taaaaacaa  gacctcctc  1860
tccggaacc  gaaggagac  atgtgcagc  ccacgaacc  catcatggc  cagtgcttt  1920
acaagagtg  gctcagtga  aagaagcgg  cagagacgg  ggccaccca  ttcaagatg  1980
gcctcttgc  gctagtgga  atcctgagg  ctaaggaac  tgcttatat  cggtgcatc  2040
agccaaatg  cgccaaaca  ccgggtcgc  ttgatgagg  gctcatccg  caccaagtg  2100
agtacctgg  acttatgga  aatctgcgt  tgcgcagag  tggctttgc  taccgtcga  2160
aatatgagg  tttcctgca  aggtacaag  cactgtgcc  agagacatg  cccgtgtgg  2220
caggacggc  ccaggatgg  gtggctgtg  tggtcagac  ccttggcta  aagccagaa  2280
agtacaaaa  gggcaggac  aagatcttc  tccgattcc  caagacctt  tttgccaca  2340
aggactccc  ggaagtccg  cggcagagt  tagccacca  gatccaggc  gcgtggagg  2400
gctttcatt  gcggcagaa  tttctccgg  tgaagcgat  agccatctg  atccagtcc  2460
ggtggcgcg  tacactggg  cggaggaag  cagccaaaa  gaagtgggc  gcccagact  2520
tccgtagac  catccgtgg  ttcattttg  gtcatgcac  ccggtgccc  gagaatgcc  2580
tcttcctgg  ccacgtgcg  acgtcattt  tgcttaacc  gaggcgaca  ctaccccgg  2640
atgttctgg  cacctcctg  cccacaccc  cacctgccc  gagagaggc  tcggagctg  2700
tccgggagc  atgcatgaa  aacatggtg  ggaaatact  ccggagtat  agccctgag  2760
ggaagcagc  gctgcagca  aaggcggtg  ctagtgaaa  tttcaaggg  aagaaggac  2820
attaccccc  gagtgtccc  agacttttc  tcagcacac  gcttggcac  gaggagatc  2880
gccccagag  gcttcaggc  ttgggctct  aacccatcc  gtatgcagt  cctgtggta  2940
aatacgacc  taagggcta  aagcctcgt  cccggcagc  gctgctcac  cccagtgct  3000
tggtcatcg  ggaggatgc  aaagtcaag  agagaattg  ttatgccaa  ctaactgga  3060
tctccgtca  tagcctgag  gatagcctg  ttgtgcttc  cgtgcagcg  gaagacagc  3120
agcagaagg  agatgtggt  ctgcagagc  atcatgtga  cgagacact  accaagacg  3180
ccctcagtg  tgaccgtgt  aataatatc  acatcaacc  gggcagcat  acgtttgca  3240
ggggtccag  cagggatgg  atcatcgac  tcacatctg  ctcagagct  ctcatcacc  3300
aggctaaga  tggccacct  gctgtggtg  ccccacggc  gaattctcg  tgatgaagg  3360
gccggtgga  ccctcctga  tcctgatgc  ttgcttagt  ccctcctcc  ctcccagtt  3420
ccaaagact  aagcttcca  acagggatc  agggacacc  tcaaagccc  cctgcagac  3480
cctgccccc  gctcatcct  tcttgaggt  atcaggaac  agggagctt  cccaggagt  3540
ggccaggcc  ggccaagca  tagaaaagc  gaggtctga  caggccagg  cagccctct  3600
ctgatgcca  atatctaag  gaagggaat  ttaactgag  ttttctctg  gactttttg  3660
tgctttata  gaaactatt  ttttaaaaa  gtcattttc  tatcctaaa  acactggat  3720
tgttttccc  gactcaaac  ggacaagga  tgtagctga  agactgact  ggctggctg  3780
ggccccccc  ctctgccaa  cctctcctca  3810



<210> 10017
<211> 1028
<212> PRT
<213> Rattus norvegicus
<308> CAA52807
<400> 10017

Met Glu Ser Ala Leu Thr Ala Arg Asp Arg Val Gly Val Gln Asp Phe 
  1               5                  10                  15
Val Leu Leu Glu Asn Phe Thr Ser Glu Ala Ala Phe Ile Glu Asn Leu 
             20                  25                  30
Arg Arg Arg Phe Arg Glu Asn Leu Ile Tyr Thr Tyr Ile Gly Pro Val 
         35                  40                  45
Leu Val Ser Val Asn Pro Tyr Arg Asp Leu Gln Ile Tyr Thr Arg Gln 
     50                  55                  60
His Met Glu Arg Tyr Arg Gly Val Ser Phe Tyr Glu Val Pro Pro His 
 65                  70                  75                  80
Leu Phe Ala Val Ala Asp Thr Val Tyr Arg Ala Leu Arg Thr Glu Arg 
                 85                  90                  95
Arg Asp Gln Ala Val Met Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr 
             100                105                110
Glu Ala Thr Lys Arg Leu Leu Gln Phe Tyr Ala Glu Thr Cys Pro Ala 
         115                120                125
Pro Glu Arg Gly Gly Ala Val Arg Asp Arg Leu Leu Gln Ser Asn Pro 
     130                135                140
Val Leu Glu Ala Phe Gly Asn Ala Lys Thr Leu Arg Asn Asp Asn Ser 
 145                150                155                160
Ser Arg Phe Gly Lys Tyr Met Asp Val Gln Phe Asp Phe Lys Gly Ala 
                 165                170                175
Pro Val Gly Gly His Ile Leu Ser Tyr Leu Leu Glu Lys Ser Arg Val 
             180                185                190
Val His Gln Asn His Gly Glu Arg Asn Phe His Val Phe Tyr Gln Leu 
         195                200                205
Leu Glu Gly Gly Glu Glu Glu Ala Leu Arg Arg Leu Gly Leu Glu Arg 
     210                215                220
Asn Pro Gln Ser Tyr Leu Tyr Leu Val Lys Gly Gln Cys Ala Lys Val 
 225                230                235                240
Ser Ser Ile Asn Asp Lys Ser Asp Trp Lys Val Val Arg Lys Ala Leu 
                 245                250                255
Ser Val Ile Asp Phe Thr Glu Asp Glu Val Glu Asp Leu Leu Ser Ile 
             260                265                270
Val Ala Ser Val Leu His Leu Gly Asn Ile His Phe Ala Ala Asp Glu 
         275                280                285
Asp Ser Asn Ala Gln Val Thr Thr Glu Asn Gln Leu Lys Tyr Leu Thr 
     290                295                300
Arg Leu Leu Gly Val Glu Gly Thr Thr Leu Arg Glu Ala Leu Thr His 
 305                310                315                320
Arg Lys Ile Ile Ala Lys Gly Glu Glu Leu Leu Ser Pro Leu Asn Leu 
                 325                330                335
Glu Gln Ala Ala Tyr Ala Arg Asp Ala Leu Ala Lys Ala Val Tyr Ser 
             340                345                350
Arg Thr Phe Thr Trp Leu Val Arg Lys Ile Asn Arg Ser Leu Ala Ser 
         355                360                365
Lys Asp Ala Glu Ser Pro Ser Trp Arg Ser Thr Thr Val Leu Gly Leu 
     370                375                380
Leu Asp Ile Tyr Gly Phe Glu Val Phe Gln His Asn Ser Phe Glu Gln 
 385                390                395                400
Phe Cys Ile Asn Tyr Cys Asn Glu Lys Leu Gln Gln Leu Phe Ile Glu 
                 405                410                415
Leu Thr Leu Lys Ser Glu Gln Glu Glu Tyr Glu Ala Glu Gly Ile Ala 
             420                425                430
Trp Glu Pro Val Gln Tyr Phe Asn Asn Lys Ile Ile Cys Asp Leu Val 
         435                440                445
Glu Glu Lys Phe Lys Gly Ile Ile Ser Ile Leu Asp Glu Glu Cys Leu 
     450                455                460
Arg Pro Gly Glu Ala Thr Asp Leu Thr Phe Leu Glu Lys Leu Glu Asp 
 465                470                475                480
Thr Ile Lys His His Pro His Phe Leu Thr His Lys Leu Ala Asp Gln 
                 485                490                495
Lys Thr Arg Lys Ser Leu Asp Arg Gly Glu Phe Arg Leu Leu His Tyr 
             500                505                510
Ala Gly Glu Val Thr Tyr Ser Val Thr Gly Phe Leu Asp Lys Asn Asn 
         515                520                525
Asp Leu Leu Phe Arg Asn Leu Lys Glu Thr Met Cys Ser Ser Thr Asn 
     530                535                540
Pro Ile Met Ala Gln Cys Phe Asp Lys Ser Glu Leu Ser Asp Lys Lys 
 545                550                555                560
Arg Pro Glu Thr Val Ala Thr Gln Phe Lys Met Ser Leu Leu Gln Leu 
                 565                570                575
Val Glu Ile Leu Arg Ser Lys Glu Pro Ala Tyr Ile Arg Cys Ile Lys 
             580                585                590
Pro Asn Asp Ala Lys Gln Pro Gly Arg Phe Asp Glu Val Leu Ile Arg 
         595                600                605
His Gln Val Lys Tyr Leu Gly Leu Met Glu Asn Leu Arg Val Arg Arg 
     610                615                620
Ala Gly Phe Ala Tyr Arg Arg Lys Tyr Glu Ala Phe Leu Gln Arg Tyr 
 625                630                635                640
Lys Ser Leu Cys Pro Glu Thr Trp Pro Val Trp Thr Gly Arg Pro Gln 
                 645                650                655
Asp Gly Val Ala Val Leu Val Arg His Leu Gly Tyr Lys Pro Glu Glu 
             660                665                670
Tyr Lys Met Gly Arg Thr Lys Ile Phe Ile Arg Phe Pro Lys Thr Leu 
         675                680                685
Phe Ala Thr Glu Asp Ser Leu Glu Val Arg Arg Gln Ser Leu Ala Thr 
     690                695                700
Lys Ile Gln Ala Ala Trp Arg Gly Phe His Trp Arg Gln Lys Phe Leu 
 705                710                715                720
Arg Val Lys Arg Ser Ala Ile Cys Ile Gln Ser Trp Trp Arg Gly Thr 
                 725                730                735
Leu Gly Arg Arg Lys Ala Ala Lys Arg Lys Trp Ala Ala Gln Thr Ile 
             740                745                750
Arg Arg Leu Ile Arg Gly Phe Ile Leu Arg His Ala Pro Arg Cys Pro 
         755                760                765
Glu Asn Ala Phe Phe Leu Asp His Val Arg Thr Ser Phe Leu Leu Asn 
     770                775                780
Leu Arg Arg Gln Leu Pro Arg Asn Val Leu Asp Thr Ser Trp Pro Thr 
 785                790                795                800
Pro Pro Pro Ala Leu Arg Glu Ala Ser Glu Leu Leu Arg Glu Leu Cys 
                 805                810                815
Met Lys Asn Met Val Trp Lys Tyr Cys Arg Ser Ile Ser Pro Glu Trp 
             820                825                830
Lys Gln Gln Leu Gln Gln Lys Ala Val Ala Ser Glu Ile Phe Lys Gly 
         835                840                845
Lys Lys Asp Asn Tyr Pro Gln Ser Val Pro Arg Leu Phe Ile Ser Thr 
     850                855                860
Arg Leu Gly Thr Glu Glu Ile Ser Pro Arg Val Leu Gln Ala Leu Gly 
 865                870                875                880
Ser Glu Pro Ile Gln Tyr Ala Val Pro Val Val Lys Tyr Asp Arg Lys 
                 885                890                895
Gly Tyr Lys Pro Arg Ser Arg Gln Leu Leu Leu Thr Pro Ser Ala Val 
             900                905                910
Val Ile Val Glu Asp Ala Lys Val Lys Gln Arg Ile Asp Tyr Ala Asn 
         915                920                925
Leu Thr Gly Ile Ser Val Ser Ser Leu Ser Asp Ser Leu Phe Val Leu 
     930                935                940
His Val Gln Arg Glu Asp Ser Lys Gln Lys Gly Asp Val Val Leu Gln 
 945                950                955                960
Ser Asp His Val Ile Glu Thr Leu Thr Lys Thr Ala Leu Ser Ala Asp 
                 965                970                975
Arg Val Asn Asn Ile Asn Ile Asn Gln Gly Ser Ile Thr Phe Ala Gly 
             980                985                990
Gly Pro Gly Arg Asp Gly Ile Ile Asp Phe Thr Ser Gly Ser Glu Leu 
         995                1000                1005
Leu Ile Thr Lys Ala Lys Asn Gly His Leu Ala Val Val Ala Pro Arg 
     1010                1015                1020
Leu Asn Ser Arg 
 1025



<210> 10018
<211> 3384
<212> DNA
<213> Homo sapiens
<308> X98507
<400> 10018

tccaagctg  attcgcggc  gcgtcgacc  cgccggccc  gggcagtga  ggggttcgg  60
tgaccatgg  cagtgcgct  accgcccgt  acagggtgg  ggtgcagga  ttcgtgctg  120
tggagaact  caccagcga  gccgccttc  tcgagaacc  acggcggcg  tttcgggag  180
atctcatct  cacctacat  ggccccgtc  tggtctctg  caatcccta  cgggacctg  240
agatctaca  ccggcaaca  atggagcgt  accgtggcg  cagcttcta  gaagtgccc  300
ctcacctgt  tgccgtggc  gacactgtg  accgagcac  gcgcacgga  cgtcgggac  360
aggctgtga  gatctctgg  gagagcggg  caggcaaga  cgaagccac  aagaagctg  420
tgcagttct  tgcagagac  tgcccagcc  cccaacgcg  aggtgccgt  cgggaccgg  480
tgctacaga  caacccggt  ctggaggcc  ttggaaatg  caagaccct  cggaacgat  540
actccagca  gttcgggaa  tacatggat  tgcagtttg  cttcaaggg  gcccccgtg  600
gtggccaca  cctcagtta  ctcctggaa  agtcacgag  ggtgcacca  aatcatggg  660
agcggaact  ccacatctt  taccagctg  tggaggggg  cgaggaaga  actcttcgc  720
ggctgggct  ggaacggaa  ccccagagc  acctgtacc  ggtgaaggg  cagtgtgcc  780
aagtctcct  catcaacga  aagagtgac  ggaaggtcg  caggaaggc  ctgacagtc  840
ttgatttca  cgaggatga  gtggaggac  tgctaagca  cgtggccag  gtccttcat  900
tgggcaaca  ccactttgc  gccaacgag  acagcaatg  ccaggtcac  accgagaac  960
agctcaagt  tctgaccag  ctcctcagc  tggaaggct  gacgctgcg  gaagccctg  1020
cacacagga  gatcatcgc  aagggggaa  agctcctga  cccgctgaa  ctggaacag  1080
ccgcgtacg  acgaaacgc  ctcgccaag  ctgtgtaca  ccgcacttt  acctggctc  1140
tcgggaaaa  caacaggtc  ctggcctcc  aggacgtgg  gagccccag  tggcggagc  1200
ccacggttc  cgggctcct  gatatttat  gcttcgaag  gtttcagca  aacagcttt  1260
agcagttct  catcaatta  tgcaacgaa  agctgcagc  gctcttcat  gaactcccg  1320
tcaagtcgg  gcaggagga  tacgaggca  agggcatcg  gtgggaacc  gtccagtat  1380
tcaacaaca  aatcatctg  gatctggtg  aggagaagt  taagggcat  atctcgatt  1440
tggatgagg  gtgtctgcg  ccgggggag  ccacagacc  gaccttcct  gagaagctg  1500
aggatactg  caagcacca  ccacacttc  tgacgcaca  gctggctga  cagaggacc  1560
ggaaatctc  gggccgagg  gaattccgc  ttctgcact  tgcggggga  gtgacctac  1620
gcgtgaccg  gtttctgga  aaaaacaat  accttctct  ccggaacct  aaggagacc  1680
tgtgtagct  aaagaatcc  attatgagc  agtgcttcg  ccggagcga  ctcagtgac  1740
agaagcggc  agagacggt  gccacccag  tcaagatga  cctcctgca  ctggtggag  1800
tcctgcagt  taaggagcc  gcctacgtc  gctgcatca  acccaatga  gccaaacag  1860
ccggccgct  tgacgaggt  ctgatccgc  accaggtga  gtacctggg  ctgttggaa  1920
acctgcgtg  gcgcagagc  ggctttgcc  atcgccgca  atacgaagc  ttcctgcaa  1980
ggtacaagt  actgtgccc  gagacgtgg  ccacgtggg  aggacggcc  caggatggg  2040
tggctgtgc  ggtccgaca  ctgggctac  agccagaag  gtacaagat  ggcaggacc  2100
agatcttca  ccgcttccc  aagaccctg  ttgccacag  ggatgccct  gaggtccgg  2160
ggcagagcc  ggccacaaa  atccaagct  cctggaggg  ctttcactg  cggcagaaa  2220
tcctccggg  gaagagatc  gccatctgc  tccagtcgt  gtggcgtgg  acactgggc  2280
ggaggaagg  agccaagag  aagtgggcg  cacagacca  ccggcggct  atccgaggc  2340
tcatcctgc  ccacgcccc  cgctgcccc  agaacgcct  cttcttgga  catgtgcgc  2400
cgtcttttt  gctaaacct  aggcggcag  tgccccgga  tgtcctgga  acctactgg  2460
ccacgcccc  acctgccct  cgagaggcc  cagagcttc  gcgggagtt  tgcataaag  2520
acatggtgt  gaaatactg  cggagtatc  gccctgagt  gaagcagca  ctgcagcag  2580
aggccgtgg  tagtgagat  ttcaagggc  agaaggata  ttaccctca  agtgtaccc  2640
ggctcttca  cagcactcg  cttggtaca  atgagatca  cccccgagt  ctgcaggcc  2700
tgggctctg  gcccattca  tatgcggtg  ctgttgtga  atacgaccg  aagggctac  2760
agcctcgct  ccggcagct  ctgctcacg  ccaacgccg  cgtcatcgt  gaggacgcc  2820
aagtcaagc  gaggattga  tacgccaac  tgaccggaa  ctctgtcag  agcctgagc  2880
acagtcttt  tgtgcttca  gtacagcgt  cggacataa  gcaaaaggg  gatgtggtg  2940
tgcagagtg  ccacgtgat  gagacgctg  ccaagacag  cctcagtgc  aaccgcgtg  3000
acagcatca  catcaacca  ggcagcata  cgtttgcag  gggccccgg  agggatggc  3060
ccattgact  cacacccgg  tcggagctg  tcatcacca  ggccaagaa  gggcacctg  3120
ctgtggtcg  cccacggct  aattatcgg  gataaaggc  cccactgga  catcccaac  3180
cccaaagct  tgcttttct  ctcctcccc  tcccagtta  caaagagtc  aatttccag  3240
cagggaccc  gggacaccc  gaagcccac  tgcaatttc  cacctcctg  ccatccctt  3300
cttgaggga  cagcagggg  caggagcta  cccaggagt  ggccaggcc  ggccacagc  3360
ataggaaag  cagggccag  gcga  3384



<210> 10019
<211> 1028
<212> PRT
<213> Homo sapiens
<308> O00159
<400> 10019

Met Asp Ser Ala Leu Thr Ala Arg Asp Arg Val Gly Val Gln Asp Phe 
  1               5                  10                  15
Val Leu Leu Glu Asn Phe Thr Ser Glu Ala Ala Phe Ile Glu Asn Leu 
             20                  25                  30
Arg Arg Arg Phe Arg Glu Asn Leu Ile Tyr Thr Tyr Ile Gly Pro Val 
         35                  40                  45
Leu Val Ser Val Asn Pro Tyr Arg Asp Leu Gln Ile Tyr Ser Arg Gln 
     50                  55                  60
His Met Glu Arg Tyr Arg Gly Val Ser Phe Tyr Glu Val Pro Pro His 
 65                  70                  75                  80
Leu Phe Ala Val Ala Asp Thr Val Tyr Arg Ala Leu Arg Thr Glu Arg 
                 85                  90                  95
Arg Asp Gln Ala Val Met Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr 
             100                105                110
Glu Ala Thr Lys Lys Leu Leu Gln Phe Tyr Ala Glu Thr Cys Pro Ala 
         115                120                125
Pro Gln Arg Gly Gly Ala Val Arg Asp Arg Leu Leu Gln Ser Asn Pro 
     130                135                140
Val Leu Glu Ala Phe Gly Asn Ala Lys Thr Leu Arg Asn Asp Asn Ser 
 145                150                155                160
Ser Arg Phe Gly Lys Tyr Met Asp Val Gln Phe Asp Phe Lys Gly Ala 
                 165                170                175
Pro Val Gly Gly His Ile Leu Ser Tyr Leu Leu Glu Lys Ser Arg Val 
             180                185                190
Val His Gln Asn His Gly Glu Arg Asn Phe His Ile Phe Tyr Gln Leu 
         195                200                205
Leu Glu Gly Gly Glu Glu Glu Thr Leu Arg Arg Leu Gly Leu Glu Arg 
     210                215                220
Asn Pro Gln Ser Tyr Leu Tyr Leu Val Lys Gly Gln Cys Ala Lys Val 
 225                230                235                240
Ser Ser Ile Asn Asp Lys Ser Asp Trp Lys Val Val Arg Lys Ala Leu 
                 245                250                255
Thr Val Ile Asp Phe Thr Glu Asp Glu Val Glu Asp Leu Leu Ser Ile 
             260                265                270
Val Ala Ser Val Leu His Leu Gly Asn Ile His Phe Ala Ala Asn Glu 
         275                280                285
Asp Ser Asn Ala Gln Val Thr Thr Glu Asn Gln Leu Lys Tyr Leu Thr 
     290                295                300
Arg Leu Leu Ser Val Glu Gly Ser Thr Leu Arg Glu Ala Leu Thr His 
 305                310                315                320
Arg Lys Ile Ile Ala Lys Gly Glu Glu Leu Leu Ser Pro Leu Asn Leu 
                 325                330                335
Glu Gln Ala Ala Tyr Ala Arg Asn Ala Leu Ala Lys Ala Val Tyr Ser 
             340                345                350
Arg Thr Phe Thr Trp Leu Val Gly Lys Ile Asn Arg Ser Leu Ala Ser 
         355                360                365
Lys Asp Val Glu Ser Pro Ser Trp Arg Ser Thr Thr Val Leu Gly Leu 
     370                375                380
Leu Asp Ile Tyr Gly Phe Glu Val Phe Gln His Asn Ser Phe Glu Gln 
 385                390                395                400
Phe Cys Ile Asn Tyr Cys Asn Glu Lys Leu Gln Gln Leu Phe Ile Glu 
                 405                410                415
Leu Pro Leu Lys Ser Glu Gln Glu Glu Tyr Glu Ala Glu Gly Ile Ala 
             420                425                430
Trp Glu Pro Val Gln Tyr Phe Asn Asn Lys Ile Ile Cys Asp Leu Val 
         435                440                445
Glu Glu Lys Phe Lys Gly Ile Ile Ser Ile Leu Asp Glu Glu Cys Leu 
     450                455                460
Arg Pro Gly Glu Ala Thr Asp Leu Thr Phe Leu Glu Lys Leu Glu Asp 
 465                470                475                480
Thr Val Lys His His Pro His Phe Leu Thr His Lys Leu Ala Asp Gln 
                 485                490                495
Arg Thr Arg Lys Ser Leu Gly Arg Gly Glu Phe Arg Leu Leu His Tyr 
             500                505                510
Ala Gly Glu Val Thr Tyr Ser Val Thr Gly Phe Leu Asp Lys Asn Asn 
         515                520                525
Asp Leu Leu Phe Arg Asn Leu Lys Glu Thr Met Cys Ser Ser Lys Asn 
     530                535                540
Pro Ile Met Ser Gln Cys Phe Asp Arg Ser Glu Leu Ser Asp Lys Lys 
 545                550                555                560
Arg Pro Glu Thr Val Ala Thr Gln Phe Lys Met Ser Leu Leu Gln Leu 
                 565                570                575
Val Glu Ile Leu Gln Ser Lys Glu Pro Ala Tyr Val Arg Cys Ile Lys 
             580                585                590
Pro Asn Asp Ala Lys Gln Pro Gly Arg Phe Asp Glu Val Leu Ile Arg 
         595                600                605
His Gln Val Lys Tyr Leu Gly Leu Leu Glu Asn Leu Arg Val Arg Arg 
     610                615                620
Ala Gly Phe Ala Tyr Arg Arg Lys Tyr Glu Ala Phe Leu Gln Arg Tyr 
 625                630                635                640
Lys Ser Leu Cys Pro Glu Thr Trp Pro Thr Trp Ala Gly Arg Pro Gln 
                 645                650                655
Asp Gly Val Ala Val Leu Val Arg His Leu Gly Tyr Lys Pro Glu Glu 
             660                665                670
Tyr Lys Met Gly Arg Thr Lys Ile Phe Ile Arg Phe Pro Lys Thr Leu 
         675                680                685
Phe Ala Thr Glu Asp Ala Leu Glu Val Arg Arg Gln Ser Leu Ala Thr 
     690                695                700
Lys Ile Gln Ala Ala Trp Arg Gly Phe His Trp Arg Gln Lys Phe Leu 
 705                710                715                720
Arg Val Lys Arg Ser Ala Ile Cys Ile Gln Ser Trp Trp Arg Gly Thr 
                 725                730                735
Leu Gly Arg Arg Lys Ala Ala Lys Arg Lys Trp Ala Ala Gln Thr Ile 
             740                745                750
Arg Arg Leu Ile Arg Gly Phe Ile Leu Arg His Ala Pro Arg Cys Pro 
         755                760                765
Glu Asn Ala Phe Phe Leu Asp His Val Arg Thr Ser Phe Leu Leu Asn 
     770                775                780
Leu Arg Arg Gln Leu Pro Arg Asn Val Leu Asp Thr Tyr Trp Pro Thr 
 785                790                795                800
Pro Pro Pro Ala Leu Arg Glu Ala Ser Glu Leu Leu Arg Glu Leu Cys 
                 805                810                815
Ile Lys Asn Met Val Trp Lys Tyr Cys Arg Ser Ile Ser Pro Glu Trp 
             820                825                830
Lys Gln Gln Leu Gln Gln Lys Ala Val Ala Ser Glu Ile Phe Lys Gly 
         835                840                845
Lys Lys Asp Asn Tyr Pro Gln Ser Val Pro Arg Leu Phe Ile Ser Thr 
     850                855                860
Arg Leu Gly Thr Asp Glu Ile Ser Pro Arg Val Leu Gln Ala Leu Gly 
 865                870                875                880
Ser Glu Pro Ile Gln Tyr Ala Val Pro Val Val Lys Tyr Asp Arg Lys 
                 885                890                895
Gly Tyr Lys Pro Arg Ser Arg Gln Leu Leu Leu Thr Pro Asn Ala Val 
             900                905                910
Val Ile Val Glu Asp Ala Lys Val Lys Gln Arg Ile Asp Tyr Ala Asn 
         915                920                925
Leu Thr Gly Ile Ser Val Ser Ser Leu Ser Asp Ser Leu Phe Val Leu 
     930                935                940
His Val Gln Arg Ala Asp Ile Lys Gln Lys Gly Asp Val Val Leu Gln 
 945                950                955                960
Ser Asp His Val Ile Glu Thr Leu Thr Lys Thr Ala Leu Ser Ala Asn 
                 965                970                975
Arg Val Asn Ser Ile Asn Ile Asn Gln Gly Ser Ile Thr Phe Ala Gly 
             980                985                990
Gly Pro Gly Arg Asp Gly Thr Ile Asp Phe Thr Pro Gly Ser Glu Leu 
         995                1000                1005
Leu Ile Thr Lys Ala Lys Asn Gly His Leu Ala Val Val Ala Pro Arg 
     1010                1015                1020
Leu Asn Tyr Arg 
 1025



<210> 10020
<211> 1832
<212> DNA
<213> Rattus norvegicus
<308> X74834
<400> 10020

ctggtgggg  ctgatagag  tggcagggt  ggctgggag  ggcgtgtag  ctgacacag  60
acactccaa  cccccaacc  caagacctg  aaagctact  tcctactca  cactgggca  120
aactgaggc  ccatgcacg  gggccaggg  cctcagctc  tcttgctgc  gctggctac  180
tgcctgggg  cccagagcc  caaccaaga  gagcggctg  ttgcggacc  gatgcgcaa  240
tacgacccc  atctgcggc  ggctgagcg  gactcagat  tggttaatg  cagcctgaa  300
cttacctta  ccaacctca  ctcccttaa  gagcgagag  aggccctca  gactaatgt  360
tggatagaa  tgcaatggt  cgactatcg  ctacgctgg  acccgaaag  ctacgaagg  420
ctgtggata  tgagggtgc  atctaccat  gtctggcag  ccgatatcg  gctgggaaa  480
aatgtggac  gtgtcttcg  ggtggcgct  tactgcaat  tgctcgtgt  ccctgatgg  540
tgtatctac  ggctgccgc  tgccatctt  cgctcctcc  gctccatct  tgtcaccta  600
ttccccttc  attggcaga  ctgctccct  gtcttccag  cccagactt  cagcaccag  660
gagatcaac  tgcagctga  ccaggagga  gggcaagcc  ttgagtgga  cttcattga  720
cccgaggct  tcacagaga  tggggaatg  gccatccgg  atcgaccag  caaaatgct  780
ctggatcct  tgactccag  agaggaggc  ggccaccag  aggtggtgt  ctacctgct  840
atccaacgc  agcccctct  ctatgtcat  aacatcatc  tcccctgtg  gctcatctc  900
tcagttgcg  tcctcatct  cttccttcc  gccaaggcg  gcggccaga  gtgcacagt  960
gccaccaac  tgctcctgg  ccagaccgt  ttccttttc  tcgtggcta  gaaggtgcc  1020
gagacctcc  aggcagtgc  gctcatcag  aagtacctg  ccttcctca  ggtggtgac  1080
atcctcatc  ttgtgaact  tgtggtcgt  ctcaatgtg  ccttgaggt  cccacacac  1140
cactccatg  cccgggggg  ccgcaaggt  tttttgagg  tcctgcccc  gctgttacg  1200
atgcatgtg  atcctcggg  tcctgctgc  gtccaggat  cccggctgc  actccagaa  1260
ggctcttcc  cagggtggc  catcatgac  cgagaggaa  gggacctct  tttgcctcg  1320
agcgaactc  tctttaggc  aaggcagcg  aatggattg  tgcaggcag  actggagaa  1380
ttagagaat  gtccagaaa  gaggcagag  caggagttc  gtggcagcc  gaagcaagc  1440
tccccggcc  tccaggcct  tgtggatgc  tgtaacctc  tggcgcgtg  ccgacacca  1500
caaagtcac  ttgacagtg  gaatgagga  tggttgctg  tgggccgag  gctggaccg  1560
gtctgtttc  tagccatgc  ctccctctt  atctgcggc  ctgctggca  cttcctcat  1620
gcccactac  accaggtgc  tgacctgcc  ttccctgga  acccccgcc  ctacttgcc  1680
ttgccagac  gagccaacc  atcactcct  cgccctgga  tcagccatg  gggtcatgc  1740
gtttatgga  ctgtattct  tgttgatcc  gatgggctc  tggggagca  tcattcttg  1800
gagaagata  aggaataaa  gaataggaa  aa  1832



<210> 10021
<211> 519
<212> PRT
<213> Rattus norvegicus
<308> P18916
<400> 10021

Met His Gly Gly Gln Gly Pro Gln Leu Leu Leu Leu Leu Leu Ala Thr 
  1               5                  10                  15
Cys Leu Gly Ala Gln Ser Arg Asn Gln Glu Glu Arg Leu Leu Ala Asp 
             20                  25                  30
Leu Met Arg Asn Tyr Asp Pro His Leu Arg Pro Ala Glu Arg Asp Ser 
         35                  40                  45
Asp Val Val Asn Val Ser Leu Lys Leu Thr Leu Thr Asn Leu Ile Ser 
     50                  55                  60
Leu Asn Glu Arg Glu Glu Ala Leu Thr Thr Asn Val Trp Ile Glu Met 
 65                  70                  75                  80
Gln Trp Cys Asp Tyr Arg Leu Arg Trp Asp Pro Lys Asp Tyr Glu Gly 
                 85                  90                  95
Leu Trp Ile Leu Arg Val Pro Ser Thr Met Val Trp Gln Pro Asp Ile 
             100                105                110
Val Leu Gly Asn Asn Val Asp Gly Val Phe Glu Val Ala Leu Tyr Cys 
         115                120                125
Asn Val Leu Val Ser Pro Asp Gly Cys Ile Tyr Trp Leu Pro Pro Ala 
     130                135                140
Ile Phe Arg Ser Ser Cys Ser Ile Ser Val Thr Tyr Phe Pro Phe Asp 
 145                150                155                160
Trp Gln Asn Cys Ser Leu Val Phe Gln Ser Gln Thr Tyr Ser Thr Ser 
                 165                170                175
Glu Ile Asn Leu Gln Leu Ser Gln Glu Asp Gly Gln Ala Ile Glu Trp 
             180                185                190
Ile Phe Ile Asp Pro Glu Ala Phe Thr Glu Asn Gly Glu Trp Ala Ile 
         195                200                205
Arg His Arg Pro Ala Lys Met Leu Leu Asp Pro Val Thr Pro Ala Glu 
     210                215                220
Glu Ala Gly His Gln Lys Val Val Phe Tyr Leu Leu Ile Gln Arg Lys 
 225                230                235                240
Pro Leu Phe Tyr Val Ile Asn Ile Ile Val Pro Cys Val Leu Ile Ser 
                 245                250                255
Ser Val Ala Ile Leu Ile Tyr Phe Leu Pro Ala Lys Ala Gly Gly Gln 
             260                265                270
Lys Cys Thr Val Ala Thr Asn Val Leu Leu Ala Gln Thr Val Phe Leu 
         275                280                285
Phe Leu Val Ala Lys Lys Val Pro Glu Thr Ser Gln Ala Val Pro Leu 
     290                295                300
Ile Ser Lys Tyr Leu Thr Phe Leu Met Val Val Thr Ile Leu Ile Val 
 305                310                315                320
Val Asn Ser Val Val Val Leu Asn Val Ser Leu Arg Ser Pro His Thr 
                 325                330                335
His Ser Met Ala Arg Gly Val Arg Lys Val Phe Leu Arg Leu Leu Pro 
             340                345                350
Gln Leu Leu Arg Met His Val His Pro Arg Ala Pro Ala Ala Val Gln 
         355                360                365
Asp Ala Arg Leu Arg Leu Gln Asn Gly Ser Ser Ser Gly Trp Pro Ile 
     370                375                380
Met Thr Arg Glu Glu Gly Asp Leu Cys Leu Pro Arg Ser Glu Leu Leu 
 385                390                395                400
Phe Arg Gln Arg Gln Arg Asn Gly Leu Val Gln Ala Val Leu Glu Lys 
                 405                410                415
Leu Glu Asn Gly Pro Glu Met Arg Gln Ser Gln Glu Phe Cys Gly Ser 
             420                425                430
Leu Lys Gln Ala Ser Pro Ala Ile Gln Ala Cys Val Asp Ala Cys Asn 
         435                440                445
Leu Met Ala Arg Ala Arg His Gln Gln Ser His Phe Asp Ser Gly Asn 
     450                455                460
Glu Glu Trp Leu Leu Val Gly Arg Val Leu Asp Arg Val Cys Phe Leu 
 465                470                475                480
Ala Met Leu Ser Leu Phe Ile Cys Gly Thr Ala Gly Ile Phe Leu Met 
                 485                490                495
Ala His Tyr Asn Gln Val Pro Asp Leu Pro Phe Pro Gly Asp Pro Arg 
             500                505                510
Pro Tyr Leu Pro Leu Pro Asp 
         515



<210> 10022
<211> 1563
<212> DNA
<213> Homo sapiens
<308> NM_005199
<400> 10022

atgcatggg  gccaggggc  gctgctcct  ctgctgctg  tggctgtct  cctgggtgg  60
acacaaagg  atctccgga  ccaggagga  cgcctgctc  cagacctga  gcaaaacta  120
gaccccaac  tgcggcccg  ggaacgaga  tcggatgtg  tcaatgtca  cctgaagct  180
accctcacc  acctcatct  cctgaacga  cgagaggaa  ccctcacca  caatgtctg  240
atagagatg  agtggtgcg  ctatcgcct  cgctgggat  cgcgagact  cgaaggcct  300
tgggtgctg  gggtgccgt  caccatggt  tggcggccg  atatcgtgc  ggagaacaa  360
gtggacggt  tcttcgagg  ggccctcta  tgcaatgtg  tcgtgtccc  tgacggctg  420
atctactgg  tgccgcctg  catcttccg  tccgcctgc  ctatctcag  cacctactt  480
cccttcgac  ggcagaact  ctcccttat  ttccagtcc  agacttaca  caccaatga  540
attgatctg  agctgagtc  ggaagatgg  cagaccatc  agtggattt  cattgaccc  600
gaggccttc  cagagaatg  ggagtgggc  atccagcac  gaccagcca  gatgctcct  660
gacccagcg  cgccagccc  ggaagcagg  caccagaag  tggtgttct  cctgctcat  720
cagcgcaag  ccctcttct  cgtcatcaa  atcatcgcc  cctgtgtgc  catctcctc  780
gtcgccatc  tcatccact  ccttcctgc  aaggctggg  gccagaagt  taccgtcgc  840
atcaacgtg  tcctggccc  gactgtctt  ctcttcctt  tggccaaga  ggtgcctga  900
acctcccag  cggtgccac  catcagcaa  tacctgacc  tcctcctgg  ggtgaccat  960
ctcattgtc  tgaatgctg  ggttgtgct  aatgtctcc  tgcggtctc  acacacaca  1020
tccatggcc  gaggggtcc  caaggtgtt  ctgaggctc  tgccccagc  gctgaggat  1080
cacgttcgc  cgctggccc  ggcagctgt  caggacacc  agtcccggc  acagaatgg  1140
tcctcggga  ggtcgatca  aactgggga  gaggtggcc  tctgcctgc  tcgcagtga  1200
ctcctcttc  agcagtggc  gcggcaagg  ctggtggcg  cagcgctgg  gaagctaga  1260
aaaggcccg  agttagggc  gagccagtt  tgtggcagc  tgaagcagg  tgccccagc  1320
atccaggcc  gtgtggaag  ctgcaacct  attgcctgt  cccggcacc  gcagagtca  1380
tttgacaat  ggaatgagg  gtggttcct  gtgggccga  tgctggacc  cgtctgctt  1440
ctggccatg  tctcgctct  catctgtgg  acagctggc  tcttcctca  ggcccacta  1500
aaccgggtg  cggccctgc  attccctgg  gatccacgc  cctacctgc  ctcaccaga  1560
tga  1563



<210> 10023
<211> 520
<212> PRT
<213> Homo sapiens
<308> NP_005190
<400> 10023

Met His Gly Gly Gln Gly Pro Leu Leu Leu Leu Leu Leu Leu Ala Val 
  1               5                  10                  15
Cys Leu Gly Gly Thr Gln Arg Asn Leu Arg Asn Gln Glu Glu Arg Leu 
             20                  25                  30
Leu Ala Asp Leu Met Gln Asn Tyr Asp Pro Asn Leu Arg Pro Ala Glu 
         35                  40                  45
Arg Asp Ser Asp Val Val Asn Val Ser Leu Lys Leu Thr Leu Thr Asn 
     50                  55                  60
Leu Ile Ser Leu Asn Glu Arg Glu Glu Ala Leu Thr Thr Asn Val Trp 
 65                  70                  75                  80
Ile Glu Met Gln Trp Cys Asp Tyr Arg Leu Arg Trp Asp Pro Arg Asp 
                 85                  90                  95
Tyr Glu Gly Leu Trp Val Leu Arg Val Pro Ser Thr Met Val Trp Arg 
             100                105                110
Pro Asp Ile Val Leu Glu Asn Asn Val Asp Gly Val Phe Glu Val Ala 
         115                120                125
Leu Tyr Cys Asn Val Leu Val Ser Pro Asp Gly Cys Ile Tyr Trp Leu 
     130                135                140
Pro Pro Ala Ile Phe Arg Ser Ala Cys Ser Ile Ser Val Thr Tyr Phe 
 145                150                155                160
Pro Phe Asp Trp Gln Asn Cys Ser Leu Ile Phe Gln Ser Gln Thr Tyr 
                 165                170                175
Ser Thr Asn Glu Ile Asp Leu Gln Leu Ser Gln Glu Asp Gly Gln Thr 
             180                185                190
Ile Glu Trp Ile Phe Ile Asp Pro Glu Ala Phe Thr Glu Asn Gly Glu 
         195                200                205
Trp Ala Ile Gln His Arg Pro Ala Lys Met Leu Leu Asp Pro Ala Ala 
     210                215                220
Pro Ala Gln Glu Ala Gly His Gln Lys Val Val Phe Tyr Leu Leu Ile 
 225                230                235                240
Gln Arg Lys Pro Leu Phe Tyr Val Ile Asn Ile Ile Ala Pro Cys Val 
                 245                250                255
Leu Ile Ser Ser Val Ala Ile Leu Ile His Phe Leu Pro Ala Lys Ala 
             260                265                270
Gly Gly Gln Lys Cys Thr Val Ala Ile Asn Val Leu Leu Ala Gln Thr 
         275                280                285
Val Phe Leu Phe Leu Val Ala Lys Lys Val Pro Glu Thr Ser Gln Ala 
     290                295                300
Val Pro Leu Ile Ser Lys Tyr Leu Thr Phe Leu Leu Val Val Thr Ile 
 305                310                315                320
Leu Ile Val Val Asn Ala Val Val Val Leu Asn Val Ser Leu Arg Ser 
                 325                330                335
Pro His Thr His Ser Met Ala Arg Gly Val Arg Lys Val Phe Leu Arg 
             340                345                350
Leu Leu Pro Gln Leu Leu Arg Met His Val Arg Pro Leu Ala Pro Ala 
         355                360                365
Ala Val Gln Asp Thr Gln Ser Arg Leu Gln Asn Gly Ser Ser Gly Trp 
     370                375                380
Ser Ile Thr Thr Gly Glu Glu Val Ala Leu Cys Leu Pro Arg Ser Glu 
 385                390                395                400
Leu Leu Phe Gln Gln Trp Gln Arg Gln Gly Leu Val Ala Ala Ala Leu 
                 405                410                415
Glu Lys Leu Glu Lys Gly Pro Glu Leu Gly Leu Ser Gln Phe Cys Gly 
             420                425                430
Ser Leu Lys Gln Ala Ala Pro Ala Ile Gln Ala Cys Val Glu Ala Cys 
         435                440                445
Asn Leu Ile Ala Cys Ala Arg His Gln Gln Ser His Phe Asp Asn Gly 
     450                455                460
Asn Glu Glu Trp Phe Leu Val Gly Arg Val Leu Asp Arg Val Cys Phe 
 465                470                475                480
Leu Ala Met Leu Ser Leu Phe Ile Cys Gly Thr Ala Gly Ile Phe Leu 
                 485                490                495
Met Ala His Tyr Asn Arg Val Pro Ala Leu Pro Phe Pro Gly Asp Pro 
             500                505                510
Arg Pro Tyr Leu Pro Ser Pro Asp 
         515                520



<210> 10024
<211> 1696
<212> DNA
<213> Rattus norvegicus
<308> X74835
<400> 10024

atggcaggg  ctgtgccca  actggggct  ctggctgcc  ttgttgtgt  tggcagctg  60
ggcctgaat  aggaacaaa  gctgatcca  cacctgttt  aggaaaaag  ctacaacaa  120
gaacttcgg  cggtggctc  aaaggagga  atagtggat  tcgccttaa  tctgaccct  180
tccaacctc  tctccctga  agaagtgga  gagaccctc  ccaccaatg  gtggataga  240
catgcatgg  tagacagcc  gctacaatg  aatgccaac  agtttggga  catcaccgt  300
ctgcgcctg  cctctgaca  ggtgtggct  ccagaaatt  tactggaga  caacaatga  360
ggctcattc  agatttctt  cgcctgcaa  gtgcttgtt  ctgactcgg  ccatgtgac  420
tggctgcca  ccgccatct  ccgctcctc  tgccccatc  cggtcacct  cttcccttt  480
gattggcag  actgctccc  caaattcag  tcactcaag  ataccgcca  ggagatcag  540
cttagcctg  agcaggagg  ggaagacaa  cgcagttac  ccattgagt  gatcatcat  600
gaccctgag  gtttcacag  gaacggtga  tgggaaata  ttcaccggg  agccaaggt  660
aacgtggac  ccagtgtcc  aatggacag  accaaccac  aagacgtca  cttctacct  720
atcatccgc  gcaagccgc  cttctacat  atcaacatc  tggtaccct  tgtgctcat  780
tccttcatg  tcaacctgg  cttctacct  ccaggcgac  gtggagaga  gacctcggt  840
gccatctca  tgctcctgg  ccaatctgt  ttcctgttg  ttatctcca  gaggctgcc  900
gccacatcc  tggccattc  tttggtagg  aagttcctg  tttttggca  ggtgctggt  960
accatggtt  tggtgatct  cgtcatcgt  ctcaacatc  acttccgaa  acccagcac  1020
catgttctg  ctgagggag  caagaagtt  ttcctggag  ccctgccca  actcctgca  1080
atgtcccgc  cagaagagg  agacccggg  cccagggct  tcatccgga  gaccagctc  1140
ctgggatac  tctccaagg  agaggagta  ttctcactt  agtcccgca  tgacctcat  1200
tttgagaag  aatcagagc  gcatgggct  gcccggcgc  tcaccacag  ccgcaagcc  1260
ccagcaagc  ctgagcagg  ccaacagga  cttttcaat  agatgaagc  agccgtgga  1320
ggggcgaac  tcatcgtca  ccacatgag  gaccagaac  gttacaatg  ggagaagga  1380
aactggaac  aggtggccc  cacagtgga  cgtctctgc  tgtttgtgg  gacgcccgt  1440
atggtggtg  gcacagcct  gatcttcct  cagggtgtc  acaaccagc  cccacccca  1500
cctttccct  gggacccct  ctcctatga  gaacaggac  ggcgcttca  ttagagcag  1560
catgagtaa  acagtcagg  agacggcgg  ctgagaatt  tccttgagc  tgtgcctat  1620
tggggctgt  tggctgggc  gaggtcatg  gaggaagag  tccctccca  gagcaattc  1680
tttctaaat  aaggag  1696



<210> 10025
<211> 517
<212> PRT
<213> Rattus norvegicus
<308> P25110
<400> 10025

Met Ala Gly Pro Val Pro Thr Leu Gly Leu Leu Ala Ala Leu Val Val 
  1               5                  10                  15
Cys Gly Ser Trp Gly Leu Asn Glu Glu Gln Arg Leu Ile Gln His Leu 
             20                  25                  30
Phe Glu Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala Arg Lys 
         35                  40                  45
Glu Asp Ile Val Asp Val Ala Leu Ser Leu Thr Leu Ser Asn Leu Ile 
     50                  55                  60
Ser Leu Lys Glu Val Glu Glu Thr Leu Thr Thr Asn Val Trp Ile Asp 
 65                  70                  75                  80
His Ala Trp Ile Asp Ser Arg Leu Gln Trp Asn Ala Asn Glu Phe Gly 
                 85                  90                  95
Asn Ile Thr Val Leu Arg Leu Pro Ser Asp Met Val Trp Leu Pro Glu 
             100                105                110
Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr Ala 
         115                120                125
Cys Asn Val Leu Val Ser Asp Ser Gly His Val Thr Trp Leu Pro Pro 
     130                135                140
Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Thr Tyr Phe Pro Phe 
 145                150                155                160
Asp Trp Gln Asn Cys Ser Leu Lys Phe Ser Ser Leu Lys Tyr Thr Ala 
                 165                170                175
Lys Glu Ile Arg Leu Ser Leu Lys Gln Glu Glu Glu Asp Asn Arg Ser 
             180                185                190
Tyr Pro Ile Glu Trp Ile Ile Ile Asp Pro Glu Gly Phe Thr Glu Asn 
         195                200                205
Gly Glu Trp Glu Ile Val His Arg Ala Ala Lys Val Asn Val Asp Pro 
     210                215                220
Ser Val Pro Met Asp Ser Thr Asn His Gln Asp Val Thr Phe Tyr Leu 
 225                230                235                240
Ile Ile Arg Arg Lys Pro Leu Phe Tyr Ile Ile Asn Ile Leu Val Pro 
                 245                250                255
Cys Val Leu Ile Ser Phe Met Ile Asn Leu Val Phe Tyr Leu Pro Gly 
             260                265                270
Asp Cys Gly Glu Lys Thr Ser Val Ala Ile Ser Val Leu Leu Ala Gln 
         275                280                285
Ser Val Phe Leu Leu Leu Ile Ser Lys Arg Leu Pro Ala Thr Ser Met 
     290                295                300
Ala Ile Pro Leu Val Gly Lys Phe Leu Leu Phe Gly Met Val Leu Val 
 305                310                315                320
Thr Met Val Val Val Ile Cys Val Ile Val Leu Asn Ile His Phe Arg 
                 325                330                335
Thr Pro Ser Thr His Val Leu Ser Glu Gly Val Lys Lys Phe Phe Leu 
             340                345                350
Glu Thr Leu Pro Lys Leu Leu His Met Ser Arg Pro Glu Glu Glu Asp 
         355                360                365
Pro Gly Pro Arg Ala Leu Ile Arg Arg Thr Ser Ser Leu Gly Tyr Ile 
     370                375                380
Ser Lys Ala Glu Glu Tyr Phe Ser Leu Lys Ser Arg Ser Asp Leu Met 
 385                390                395                400
Phe Glu Lys Gln Ser Glu Arg His Gly Leu Ala Arg Arg Leu Thr Thr 
                 405                410                415
Ala Arg Lys Pro Pro Ala Ser Ser Glu Gln Val Gln Gln Glu Leu Phe 
             420                425                430
Asn Glu Met Lys Pro Ala Val Asp Gly Ala Asn Phe Ile Val Asn His 
         435                440                445
Met Arg Asp Gln Asn Ser Tyr Asn Glu Glu Lys Asp Asn Trp Asn Gln 
     450                455                460
Val Ala Arg Thr Val Asp Arg Leu Cys Leu Phe Val Val Thr Pro Val 
 465                470                475                480
Met Val Val Gly Thr Ala Trp Ile Phe Leu Gln Gly Val Tyr Asn Gln 
                 485                490                495
Pro Pro Pro Gln Pro Phe Pro Gly Asp Pro Phe Ser Tyr Asp Glu Gln 
             500                505                510
Asp Arg Arg Phe Ile 
         515



<210> 10026
<211> 1741
<212> DNA
<213> Homo sapiens
<308> X55019
<400> 10026

tgggatgga  gggccagtg  tgacactgg  gctgctggc  gccctggcg  tgtgtggca  60
ctgggggct  aacgaggag  agcggctga  ccggcacct  tttcaagag  agggctaca  120
caaggagct  cggcccgtg  cacacaaag  ggagagtgt  gacgttgcc  tggccctca  180
actctccaa  ctcatctcc  tgaaagaag  tgaggagac  ctcactacc  atgtgtgga  240
agagcacgg  tggacagac  accggctga  gtggaatgc  gaagaattt  gaaacatca  300
tgtcctgcg  ctccccccg  acatggtgt  gctcccaga  attgtgctg  agaacaaca  360
tgacggctc  ttccagatc  cctactcct  caacgtgct  gtctaccac  acggcttcg  420
gtactggct  ccacctgcc  tcttccgct  ctcctgccc  atctctgtc  cctatttcc  480
cttcgactg  cagaactgc  ccctcaagt  cagttccct  aagtatacg  ccaaagaga  540
caccctgag  ctgaaacag  atgccaagg  gaaccgcac  taccccgtg  agtggatca  600
cattgatcc  gaaggcttc  cagagaacg  ggagtggga  atagtccac  ggccggcca  660
ggtcaacgt  gaccccaga  cccctctgg  cagccccag  cgccaggac  tcaccttct  720
cctcatcat  cgccgcaag  ccctcttct  catcatcaa  atcctggtg  cctgcgtgc  780
catctcctt  atggtcaac  tggtcttct  cctaccggc  gacagtggt  agaagacat  840
agtggccat  tcggtgctc  tggctcagt  tgtcttcct  ctgctcatc  ccaagcgtc  900
gcctgccac  tccatggcc  tccccctta  cggcaagtt  ctgctcttc  gcatggtgc  960
ggtcaccat  gttgtggtg  tctgtgtca  cgtgctcaa  atccacttc  gaacaccca  1020
cacccatgt  ctgtctgag  gggtcaaga  gctcttcct  gagaccctg  cggagctcc  1080
gcacatgtc  cgcccagca  aggatggac  cagccctgg  gccctggtg  ggaggagca  1140
ctccctggg  tacatctcc  aggccgagg  gtacttcct  ctcaagtcc  gcagtgacc  1200
catgttcga  aagcagtca  agcggcatg  gctggccag  cgcctcacc  ctgcacgcc  1260
gcccccagc  agctctgag  aggcccagc  ggaactctt  aatgagctg  agccagctg  1320
ggatggggc  aacttcatt  ttaaccaca  gagggacca  aacaattac  atgaggaga  1380
agacagctg  aaccgagtg  cccgcacag  ggaccgcct  tgcctgttt  tggtgacgc  1440
tgtcatggt  gtgggcaca  cctggatct  cctgcaggg  gtttacaac  agccaccac  1500
ccagccttt  cctggggac  cctactcct  caacgtgca  gacaagcgc  tcatctagg  1560
tgggcctgt  ggggagcca  gagacagca  ggtctgaga  aggagccac  gtccctaat  1620
acacccact  ctagccctg  ggctcgtgc  cctcagact  gggaagagt  caaggaagg  1680
agggagcag  cactcctca  tgctcaatg  ctcccctga  atcaagaca  gggccaccc  1740
a  1741



<210> 10027
<211> 517
<212> PRT
<213> Homo sapiens
<308> Q07001
<400> 10027

Met Glu Gly Pro Val Leu Thr Leu Gly Leu Leu Ala Ala Leu Ala Val 
  1               5                  10                  15
Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
             20                  25                  30
Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
         35                  40                  45
Glu Glu Ser Val Asp Val Ala Leu Ala Leu Thr Leu Ser Asn Leu Ile 
     50                  55                  60
Ser Leu Lys Glu Val Glu Glu Thr Leu Thr Thr Asn Val Trp Ile Glu 
 65                  70                  75                  80
His Gly Trp Thr Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe Gly 
                 85                  90                  95
Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro Glu 
             100                105                110
Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr Ser 
         115                120                125
Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro Pro 
     130                135                140
Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Thr Tyr Phe Pro Phe 
 145                150                155                160
Asp Trp Gln Asn Cys Ser Leu Lys Phe Ser Ser Leu Lys Tyr Thr Ala 
                 165                170                175
Lys Glu Ile Thr Leu Ser Leu Lys Gln Asp Ala Lys Glu Asn Arg Thr 
             180                185                190
Tyr Pro Val Glu Trp Ile Ile Ile Asp Pro Glu Gly Phe Thr Glu Asn 
         195                200                205
Gly Glu Trp Glu Ile Val His Arg Pro Ala Arg Val Asn Val Asp Pro 
     210                215                220
Arg Ala Pro Leu Asp Ser Pro Ser Arg Gln Asp Ile Thr Phe Tyr Leu 
 225                230                235                240
Ile Ile Arg Arg Lys Pro Leu Phe Tyr Ile Ile Asn Ile Leu Val Pro 
                 245                250                255
Cys Val Leu Ile Ser Phe Met Val Asn Leu Val Phe Tyr Leu Pro Ala 
             260                265                270
Asp Ser Gly Glu Lys Thr Ser Val Ala Ile Ser Val Leu Leu Ala Gln 
         275                280                285
Ser Val Phe Leu Leu Leu Ile Ser Lys Arg Leu Pro Ala Thr Ser Met 
     290                295                300
Ala Ile Pro Leu Ile Gly Lys Phe Leu Leu Phe Gly Met Val Leu Val 
 305                310                315                320
Thr Met Val Val Val Ile Cys Val Ile Val Leu Asn Ile His Phe Arg 
                 325                330                335
Thr Pro Ser Thr His Val Leu Ser Glu Gly Val Lys Lys Leu Phe Leu 
             340                345                350
Glu Thr Leu Pro Glu Leu Leu His Met Ser Arg Pro Ala Glu Asp Gly 
         355                360                365
Pro Ser Pro Gly Ala Leu Val Arg Arg Ser Ser Ser Leu Gly Tyr Ile 
     370                375                380
Ser Lys Ala Glu Glu Tyr Phe Leu Leu Lys Ser Arg Ser Asp Leu Met 
 385                390                395                400
Phe Glu Lys Gln Ser Glu Arg His Gly Leu Ala Arg Arg Leu Thr Thr 
                 405                410                415
Ala Arg Arg Pro Pro Ala Ser Ser Glu Gln Ala Gln Gln Glu Leu Phe 
             420                425                430
Asn Glu Leu Lys Pro Ala Val Asp Gly Ala Asn Phe Ile Val Asn His 
         435                440                445
Met Arg Asp Gln Asn Asn Tyr Asn Glu Glu Lys Asp Ser Trp Asn Arg 
     450                455                460
Val Ala Arg Thr Val Asp Arg Leu Cys Leu Phe Val Val Thr Pro Val 
 465                470                475                480
Met Val Val Gly Thr Ala Trp Ile Phe Leu Gln Gly Val Tyr Asn Gln 
                 485                490                495
Pro Pro Pro Gln Pro Phe Pro Gly Asp Pro Tyr Ser Tyr Asn Val Gln 
             500                505                510
Asp Lys Arg Phe Ile 
         515



<210> 10028
<211> 1460
<212> DNA
<213> Rattus norvegicus
<308> X74978
<400> 10028

ttggtcttt  tttcagcgt  gctgtaaaa  aacaaccag  tgccagtgt  atcaggaaa  60
gagttaggt  aaacttgtg  gtctgccgg  gatccatga  tagcacaaa  aactctatt  120
ctgaaggat  cgaagattt  gcttgagcg  gtgagtaaa  ctgccctgg  aatgtctga  180
gtaaaaaca  gtttcagac  aagcctacc  agttagcgt  caagcatga  aaagaagac  240
cttatccca  gctaatggg  aaaggacct  attcacctg  caacaacgc  cacctgttc  300
cctgccttc  ctcacgagg  aaaaagatg  gacaggagg  cacctggag  agttttcca  360
acccagcct  gaacgatca  attttatat  tatgtcaaa  gacgctggg  agcagaact  420
aataataaa  gcctcttgg  gtccattca  gttccttcc  aagaaacta  aaaatcaaa  480
tttctggta  gctccatat  tatggcatc  atacagcag  tcctggaag  cacttgtat  540
caatgaata  caagagcaa  atataccga  acagcacct  agaggtgag  atgctgtgc  600
gagggtccc  caaaactcc  atgcctgcg  tgcagaatc  aaagttgat  cataagagg  660
gatgtgagg  cacacacac  cacacacac  cacacacac  ccactgaaa  aaaatgaga  720
attctagat  cctctgagt  caaaactta  tggcacact  agtgtagct  caaaatctg  780
tcagaggac  aacaatgtt  aaggctttg  tcccggcac  ttcagaagc  atagccaag  840
gccagccta  ggccactgc  atgtatgca  aaagctgtg  ccacatgat  ctctttaga  900
tctcgactg  ccgtgtggc  gaacagacc  gtgtttcta  acggtggat  aagatgaat  960
gctcctggc  agtggcctc  actggaagc  agacctaga  catttcatg  ctaacccaa  1020
acatggctt  agaagctcc  ttgtgttat  tttccccat  taaagaact  tcttctagc  1080
gtaaggcag  gaaaggcgg  ggataaaag  atcataatt  ggaagtcga  agggagatg  1140
ttaaataat  aactttgaa  agcttctgt  tatttcgtt  gaataaaat  tctgcaatc  1200
gacttgagg  ctctccttt  taccttggg  gtgggggac  gaagttgtg  gatagaagt  1260
actgttaat  taatataaa  ttactcagc  gggttttta  gttaatatt  tacattaaa  1320
tatagtttg  acttcttct  ataaaaaat  agcagtaga  agctcgacc  cagctactc  1380
agatagaat  tggcaagaa  acatcctta  gaagtttac  gtgtgttac  gaagtgata  1440
gtcttactt  gaacgagaac  1460



<210> 10029
<211> 381
<212> PRT
<213> Rattus norvegicus
<308> NP_064457
<400> 10029

Met Arg Ala Val Pro Leu His Leu Val Gly Thr Ala Ser Leu Thr Leu 
  1               5                  10                  15
Gly Phe Leu Leu Leu Leu Ser Leu Arg Leu Asp Pro Gly Gln Ala Lys 
             20                  25                  30
Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Gly Pro 
         35                  40                  45
Ile Glu Thr Phe Pro Asn Asp Pro Ile Lys Glu Ser Ser Trp Pro Gln 
     50                  55                  60
Gly Phe Gly Gln Leu Thr Lys Trp Gly Met Gly Gln His Tyr Glu Leu 
 65                  70                  75                  80
Gly Ser Tyr Ile Arg Arg Arg Tyr Gly Arg Phe Leu Asn Asn Ser Tyr 
                 85                  90                  95
Lys His Asp Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr Leu 
             100                105                110
Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly Ile 
         115                120                125
Ser Ile Trp Asn Pro Arg Leu Leu Trp Gln Pro Ile Pro Val His Thr 
     130                135                140
Val Ser Leu Ser Glu Asp Arg Leu Leu Tyr Leu Pro Phe Arg Asp Cys 
 145                150                155                160
Pro Arg Phe Gln Glu Leu Lys Ser Glu Thr Leu Lys Ser Glu Glu Phe 
                 165                170                175
Leu Lys Arg Leu Gln Pro Tyr Lys Ser Phe Ile Asp Thr Leu Pro Ser 
             180                185                190
Leu Ser Gly Phe Glu Asp Gln Asp Leu Phe Glu Ile Trp Ser Arg Leu 
         195                200                205
Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Phe Arg Thr 
     210                215                220
Trp Ala Thr Glu Asp Ala Met Thr Lys Leu Lys Glu Leu Ser Glu Leu 
 225                230                235                240
Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser Arg 
                 245                250                255
Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Lys Asn Met Lys Leu 
             260                265                270
Ala Thr Gln Pro Gln Lys Ala Arg Lys Leu Ile Met Tyr Ser Ala Tyr 
         275                280                285
Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Glu Leu Tyr Asn Gly 
     290                295                300
Leu Leu Pro Pro Tyr Ala Ser Cys His Ile Met Glu Leu Tyr Gln Asp 
 305                310                315                320
Asn Gly Gly Thr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln Asn 
                 325                330                335
Glu Pro Tyr Pro Leu Thr Leu Pro Gly Cys Thr His Ser Cys Pro Leu 
             340                345                350
Glu Lys Phe Ala Glu Leu Leu Asp Pro Val Ile Pro Gln Asp Trp Ala 
         355                360                365
Thr Glu Cys Met Gly Thr Ser Asn His Gln Ala Ser Leu 
     370                375                380



<210> 10030
<211> 1786
<212> DNA
<213> Homo sapiens
<308> XM_039822
<400> 10030

gaagtggta  cagttcctc  taactcctg  cagaaacag  tctcctcaa  atgagagct  60
cacccctcc  cctggccag  gcagcaagc  ttagccttg  cttcttgtt  ctgcttttt  120
tctggctag  ccgaagtgt  ctagccaag  agttgaagt  tgtgacttt  gtgtttcgg  180
atggagacc  aagtcccat  gacaccttt  ccactgacc  cataaagga  tcctcatgg  240
cacaaggat  tggccaact  acccagctg  gcatggagc  gcattatga  cttggagag  300
atataagaa  gagatatag  aaattcttg  atgagtcct  taaacatga  caggtttat  360
ttcgaagca  agacgttga  cggactttg  tgagtgcta  gacaaacct  gcagccctg  420
ttcccccag  aggtgtcag  atctggaat  ctatcctac  ctggcagcc  atcccggtg  480
acacagttc  tctttctga  gatcagttg  tatacctgc  tttcaggaa  tgccctcgt  540
ttcaagaac  tgagagtga  actttgaaa  cagaggaat  ccagaagag  ctgcaccct  600
ataaggatt  tatagctac  ttgggaaaa  tttcaggat  acatggcca  gaccttttt  660
gaatttgga  taaagtcta  gacccttta  attgtgaga  tgttcacaa  ttcacttta  720
cctcctggg  cactgagga  accatgact  agttgagag  attgtcaga  ttgtccctc  780
tgtccctct  tggaattca  aagcagaaa  agaaatcta  gctccaagg  ggtgtcctg  840
tcaatgaaa  cctcaatca  atgaagaga  caactcaga  accaagcta  aaaaaactc  900
tcatgtatt  tgcgcatga  actactgtg  gtggcctac  gatggcgct  gatgtttac  960
acggactcc  tcctcccta  gcttcttgc  acttgacgg  attgtactt  gagaagggg  1020
agtactttg  ggagatgta  tatcggaat  agacgcagc  cgagccgta  cccctcatg  1080
tacctggct  cagccccag  tgtcctctg  agaggtttg  tgagctggt  ggccctgtg  1140
tccctcaag  ctggtccac  gagtgtatg  ccacaaaca  ccatcaagt  ctaaaggtc  1200
tctttgctg  tgccttttg  ctgatatct  ctgtcctaa  ggtactact  tttatccac  1260
ttcgccgtg  actctgctg  cagagagaa  cctatggga  catctgaac  gacagctgg  1320
taagccagg  caacctcct  tgacacagc  tctctcagt  gtgccgcat  taaaggaca  1380
gcttttgcc  tgtgggcat  gccatcctc  caccctgcc  tttgaatct  cccagagca  1440
ggtctgaac  cacagtgac  cacaggctg  tgctggatg  acactcagg  tacctaggt  1500
ttctcataa  ggagtggta  tgcaggctg  ttgttcagc  agaaagagg  tgttatgca  1560
aggatggtt  tattctctg  cacagttgt  cggagagaa  taagaagcc  aactccaat  1620
agcctttta  ctgcaaaga  tgaagggtg  gaaggtgga  aaagacata  attagaaaa  1680
tactggata  tgggggaag  tagactaga  gtattatta  acagggtga  tcttacgaa  1740
gaagaccca  tcataaatt  taaataaac  ttttattta  ctatta  1786



<210> 10031
<211> 418
<212> PRT
<213> Homo sapiens
<308> XP_039822
<400> 10031

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
  1               5                  10                  15
Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
             20                  25                  30
Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
         35                  40                  45
Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
     50                  55                  60
Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
 65                  70                  75                  80
Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                 85                  90                  95
Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
             100                105                110
Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
         115                120                125
Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
     130                135                140
Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
 145                150                155                160
Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                 165                170                175
Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
             180                185                190
Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
         195                200                205
Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
     210                215                220
Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
 225                230                235                240
Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                 245                250                255
Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
             260                265                270
Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
         275                280                285
His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
     290                295                300
Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
 305                310                315                320
Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                 325                330                335
His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
             340                345                350
Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
         355                360                365
Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Val Leu Lys Val Ile 
     370                375                380
Phe Ala Val Ala Phe Cys Leu Ile Ser Ala Val Leu Met Val Leu Leu 
 385                390                395                400
Phe Ile His Ile Arg Arg Gly Leu Cys Trp Gln Arg Glu Ser Tyr Gly 
                 405                410                415
Asn Ile 
             420



<210> 10032
<211> 1454
<212> DNA
<213> Rattus norvegicus
<308> X75207
<400> 10032

ccgtcgacg  ccattacca  tcgcgaaac  ggcgcagta  cagagagct  cagactccg  60
gcgctccgg  gaccggtcg  agagcgcga  gcagcgtca  cagcagaca  cggagccca  120
cccggacca  agccctccc  aggcggccg  gcatggaac  ccagctcct  tgctgcgaa  180
tggagacca  ccgccgcgc  taccctgac  ccaatctcc  caacgaccg  gtgctgcga  240
ccatgctta  gactgagga  acctgcgcg  cctccgttt  ttacttcaa  tgcgtgcag  300
gggagattg  gccatccat  cggaaaatc  tggccacct  gatgctaga  gtctgcgag  360
agcagaagt  cgaagagga  gtcttcccg  tggccatga  ctacctgga  cggttcttg  420
ctctggagc  cctgaagaa  agccgcctg  agcttctgg  ggccacctg  atgttcgtg  480
cctctaaga  gaaggagac  attcccctg  ctgccgaga  gttgtgcat  tacactgac  540
actctatcc  ccccgagga  ttgctgcaa  tggaactgc  tctggtgaa  aagctcaaa  600
ggaacctgg  cgccatgac  ccccacgat  tcatcgaac  cttcctctc  aaaatgcca  660
aggcggatg  gaacaagca  atcatccgc  aacatgcac  gacctttgt  gccctctgt  720
ccacagatg  gaagttcat  tccaaccca  cctccatgg  ggctgctgg  agtgtggtg  780
ccgcgatgc  gggcctgaa  ctgggcagc  ccaacaact  cctctcctg  taccgcaca  840
cgcactttc  ttccagagt  atcaagtgt  acccggact  cctccgtgc  tgccaggaa  900
agattgaag  ccttctgga  tcaagcctg  gccaggccc  gcagaacat  gatcccaag  960
ccaccgagg  ggaagggga  gtggaggaa  aagctggtc  ggcttgcac  cccaccgac  1020
tccgagatg  ggacatctg  gggccaccg  caggcggga  tcaccaagt  gtggcatcg  1080
gaagagaaa  gagccagcc  gggtgctcc  gacgaggtc  ccttgggat  tgttgttac  1140
agaagggga  gttttgttc  ctttgttgg  tgtttttcc  taatctttc  cctttctat  1200
tgatttaag  aaaagagaa  aaaaatacc  gaaagctgt  ttaaagaga  agagagaga  1260
agaattcgc  tcaccctga  tatagggag  cgggggggt  ctacaaaaa  agaattctg  1320
accccagta  tcaactagt  ttctattaa  gtgcttgtc  gttctaaga  taggattaa  1380
acacaggaa  tcttgagaa  gatttttga  tcttttatg  gtttaagaa  aaaaagctt  1440
agaaacatt  cttt  1454



<210> 10033
<211> 295
<212> PRT
<213> Rattus norvegicus
<308> P39948
<400> 10033

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
  1               5                  10                  15
Tyr Pro Asp Thr Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
             20                  25                  30
Lys Thr Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
         35                  40                  45
Gln Arg Glu Ile Val Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Leu Lys Lys 
                 85                  90                  95
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
             100                105                110
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
     130                135                140
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
 145                150                155                160
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Asp Glu Asn Lys Gln 
                 165                170                175
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
             180                185                190
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
         195                200                205
Val Ala Ala Met Gln Gly Leu Asn Leu Gly Ser Pro Asn Asn Phe Leu 
     210                215                220
Ser Cys Tyr Arg Thr Thr His Phe Leu Ser Arg Val Ile Lys Cys Asp 
 225                230                235                240
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                 245                250                255
Ser Ser Leu Arg Gln Ala Gln Gln Asn Ile Asp Pro Lys Ala Thr Glu 
             260                265                270
Glu Glu Gly Glu Val Glu Glu Glu Ala Gly Leu Ala Cys Thr Pro Thr 
         275                280                285
Asp Val Arg Asp Val Asp Ile 
     290                295



<210> 10035
<211> 295
<212> PRT
<213> Homo sapiens
<308> P24385
<400> 10035

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
  1               5                  10                  15
Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
             20                  25                  30
Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
         35                  40                  45
Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                 85                  90                  95
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
             100                105                110
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
     130                135                140
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
 145                150                155                160
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                 165                170                175
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
             180                185                190
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
         195                200                205
Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
     210                215                220
Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
 225                230                235                240
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                 245                250                255
Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
             260                265                270
Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
         275                280                285
Asp Val Arg Asp Val Asp Ile 
     290                295



<210> 10036
<211> 1454
<212> DNA
<213> Rattus norvegicus
<308> X75207
<400> 10036

ccgtcgacg  ccattacca  tcgcgaaac  ggcgcagta  cagagagct  cagactccg  60
gcgctccgg  gaccggtcg  agagcgcga  gcagcgtca  cagcagaca  cggagccca  120
cccggacca  agccctccc  aggcggccg  gcatggaac  ccagctcct  tgctgcgaa  180
tggagacca  ccgccgcgc  taccctgac  ccaatctcc  caacgaccg  gtgctgcga  240
ccatgctta  gactgagga  acctgcgcg  cctccgttt  ttacttcaa  tgcgtgcag  300
gggagattg  gccatccat  cggaaaatc  tggccacct  gatgctaga  gtctgcgag  360
agcagaagt  cgaagagga  gtcttcccg  tggccatga  ctacctgga  cggttcttg  420
ctctggagc  cctgaagaa  agccgcctg  agcttctgg  ggccacctg  atgttcgtg  480
cctctaaga  gaaggagac  attcccctg  ctgccgaga  gttgtgcat  tacactgac  540
actctatcc  ccccgagga  ttgctgcaa  tggaactgc  tctggtgaa  aagctcaaa  600
ggaacctgg  cgccatgac  ccccacgat  tcatcgaac  cttcctctc  aaaatgcca  660
aggcggatg  gaacaagca  atcatccgc  aacatgcac  gacctttgt  gccctctgt  720
ccacagatg  gaagttcat  tccaaccca  cctccatgg  ggctgctgg  agtgtggtg  780
ccgcgatgc  gggcctgaa  ctgggcagc  ccaacaact  cctctcctg  taccgcaca  840
cgcactttc  ttccagagt  atcaagtgt  acccggact  cctccgtgc  tgccaggaa  900
agattgaag  ccttctgga  tcaagcctg  gccaggccc  gcagaacat  gatcccaag  960
ccaccgagg  ggaagggga  gtggaggaa  aagctggtc  ggcttgcac  cccaccgac  1020
tccgagatg  ggacatctg  gggccaccg  caggcggga  tcaccaagt  gtggcatcg  1080
gaagagaaa  gagccagcc  gggtgctcc  gacgaggtc  ccttgggat  tgttgttac  1140
agaagggga  gttttgttc  ctttgttgg  tgtttttcc  taatctttc  cctttctat  1200
tgatttaag  aaaagagaa  aaaaatacc  gaaagctgt  ttaaagaga  agagagaga  1260
agaattcgc  tcaccctga  tatagggag  cgggggggt  ctacaaaaa  agaattctg  1320
accccagta  tcaactagt  ttctattaa  gtgcttgtc  gttctaaga  taggattaa  1380
acacaggaa  tcttgagaa  gatttttga  tcttttatg  gtttaagaa  aaaaagctt  1440
agaaacatt  cttt  1454



<210> 10037
<211> 295
<212> PRT
<213> Rattus norvegicus
<308> P39948
<400> 10037

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
  1               5                  10                  15
Tyr Pro Asp Thr Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
             20                  25                  30
Lys Thr Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
         35                  40                  45
Gln Arg Glu Ile Val Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Leu Lys Lys 
                 85                  90                  95
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
             100                105                110
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
     130                135                140
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
 145                150                155                160
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Asp Glu Asn Lys Gln 
                 165                170                175
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
             180                185                190
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
         195                200                205
Val Ala Ala Met Gln Gly Leu Asn Leu Gly Ser Pro Asn Asn Phe Leu 
     210                215                220
Ser Cys Tyr Arg Thr Thr His Phe Leu Ser Arg Val Ile Lys Cys Asp 
 225                230                235                240
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                 245                250                255
Ser Ser Leu Arg Gln Ala Gln Gln Asn Ile Asp Pro Lys Ala Thr Glu 
             260                265                270
Glu Glu Gly Glu Val Glu Glu Glu Ala Gly Leu Ala Cys Thr Pro Thr 
         275                280                285
Asp Val Arg Asp Val Asp Ile 
     290                295



<210> 10039
<211> 295
<212> PRT
<213> Homo sapiens
<308> P24385
<400> 10039

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
  1               5                  10                  15
Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
             20                  25                  30
Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
         35                  40                  45
Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
     50                  55                  60
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
 65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                 85                  90                  95
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
             100                105                110
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
         115                120                125
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
     130                135                140
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
 145                150                155                160
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                 165                170                175
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
             180                185                190
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
         195                200                205
Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
     210                215                220
Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
 225                230                235                240
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                 245                250                255
Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
             260                265                270
Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
         275                280                285
Asp Val Arg Asp Val Asp Ile 
     290                295



<210> 10040
<211> 1700
<212> DNA
<213> Rattus norvegicus
<308> X76724
<400> 10040

acccatctt  aggattccc  gaacccacc  tgcctgttt  acacatctg  aattctcta  60
tagcgctcc  attgtgttt  gagttttaa  aaaaattct  aagatttag  gtctcgtgg  120
tccagtgct  gtccagggg  tcgcccaat  cgccgccac  cacgcgagg  gtcccgacc  180
gagggatac  gctcactca  cacagaacc  gccccgcgt  acttttacg  caaggtagc  240
cggccaatg  gagccagag  tcaatgatt  tgactctac  cgcgcggac  aatcgacgc  300
tcggcggga  ctgcaggat  tgcatggac  ccgaaggcc  ctgccaatg  gactgtgac  360
ggcgtgaat  atagccaat  ataggatgc  aggggcgtg  ccgcgggcg  cccacgagg  420
aaagatgct  cgggcggaa  ctgccggag  aagcgggat  cgggggtgc  gaagtcgca  480
gggcagggc  ggaaggaag  tccggaacg  ggcgtggga  ccggagctg  aggccccca  540
gatttcccc  ctgtgaaaa  acacgctga  ctagataag  gaggccggc  ccatgtatc  600
ggaatcaac  acggggtct  cagctcgac  ctccctgcg  cagacaggc  cccccggga  660
gatctacag  actcggtat  ggagtccca  aagacagct  cagttttac  ggaatctgg  720
caaatctgg  cttcgggtc  cctgcctgg  gcttggaac  tgggtgacc  tcggaggcc  780
gatcacaga  gagatggca  agcacctaa  gaccttggc  tatgacaat  gcatcaacc  840
gttcgatac  gcggaggtc  acgcagctg  caaggctga  gtggtatta  ggaacatca  900
taagaagaa  gggtggaga  ggtccagcc  tgtcatcac  accaagatc  tctggggcg  960
aaaggcaga  accgagaga  gcctttccc  gaagcacat  atcgaagga  tgaaagctt  1020
cctggagag  ctgcagctg  agtacgtgg  tgtggtttt  gccaaccgc  cagacccca  1080
cacacccat  gaagagact  tgcgggcca  gacccatgt  atcaaccaa  ggatggcca  1140
gtactgggg  acatcacgc  ggagctcca  ggagatcat  gaggcctac  cggtggctc  1200
gcagttcaa  ctgatcccg  ccatctgcg  gcaagcgga  taccacatg  tccagaggg  1260
gaaggtaga  gtccagctg  cagagctgt  ccacaagat  ggagtaggt  ccatgacct  1320
gtcccctct  gcctgcggc  ttgtctcag  gaagtatga  agtggcatc  caccctact  1380
cagagcctc  ctgaagggc  accagtggt  gaaggacaa  atcctgagt  aggagggtc  1440
ccgccagca  gccaaactg  aggaactgc  ggccattgc  gagcgccta  gctgcaccc  1500
cccacagct  gccatagcc  ggtgcctga  gaacgaggg  gtcagctcc  tgctcctgg  1560
tgcttccaa  gcagaacaa  ttatggaga  cattggagc  atacaggtc  ttccaaaat  1620
gtcgtcctc  atcgtccac  agatcgaca  cattctggg  aataaaccc  acagcaaaa  1680
ggactatag  tcctaagtca  1700



<210> 10041
<211> 367
<212> PRT
<213> Rattus norvegicus
<308> Q64284
<400> 10041

Met Tyr Pro Glu Ser Thr Thr Gly Ser Pro Ala Arg Leu Ser Leu Arg 
  1               5                  10                  15
Gln Thr Gly Ser Pro Gly Met Ile Tyr Ser Thr Arg Tyr Gly Ser Pro 
             20                  25                  30
Lys Arg Gln Leu Gln Phe Tyr Arg Asn Leu Gly Lys Ser Gly Leu Arg 
         35                  40                  45
Val Ser Cys Leu Gly Leu Gly Thr Trp Val Thr Phe Gly Gly Gln Ile 
     50                  55                  60
Thr Asp Glu Met Ala Glu His Leu Met Thr Leu Ala Tyr Asp Asn Gly 
 65                  70                  75                  80
Ile Asn Leu Phe Asp Thr Ala Glu Val Tyr Ala Ala Gly Lys Ala Glu 
                 85                  90                  95
Val Val Leu Gly Asn Ile Ile Lys Lys Lys Gly Trp Arg Arg Ser Ser 
             100                105                110
Leu Val Ile Thr Thr Lys Ile Phe Trp Gly Gly Lys Ala Glu Thr Glu 
         115                120                125
Arg Gly Leu Ser Arg Lys His Ile Ile Glu Gly Leu Lys Ala Ser Leu 
     130                135                140
Glu Arg Leu Gln Leu Glu Tyr Val Asp Val Val Phe Ala Asn Arg Pro 
 145                150                155                160
Asp Pro Asn Thr Pro Met Glu Glu Thr Val Arg Ala Met Thr His Val 
                 165                170                175
Ile Asn Gln Gly Met Ala Met Tyr Trp Gly Thr Ser Arg Trp Ser Ser 
             180                185                190
Met Glu Ile Met Glu Ala Tyr Ser Val Ala Arg Gln Phe Asn Leu Ile 
         195                200                205
Pro Pro Ile Cys Glu Gln Ala Glu Tyr His Met Phe Gln Arg Glu Lys 
     210                215                220
Val Glu Val Gln Leu Pro Glu Leu Phe His Lys Ile Gly Val Gly Ala 
 225                230                235                240
Met Thr Trp Ser Pro Leu Ala Cys Gly Ile Val Ser Gly Lys Tyr Asp 
                 245                250                255
Ser Gly Ile Pro Pro Tyr Ser Arg Ala Ser Leu Lys Gly Tyr Gln Trp 
             260                265                270
Leu Lys Asp Lys Ile Leu Ser Glu Glu Gly Arg Arg Gln Gln Ala Lys 
         275                280                285
Leu Lys Glu Leu Gln Ala Ile Ala Glu Arg Leu Gly Cys Thr Leu Pro 
     290                295                300
Gln Leu Ala Ile Ala Trp Cys Leu Arg Asn Glu Gly Val Ser Ser Val 
 305                310                315                320
Leu Leu Gly Ala Ser Asn Ala Glu Gln Leu Met Glu Asn Ile Gly Ala 
                 325                330                335
Ile Gln Val Leu Pro Lys Leu Ser Ser Ser Ile Val His Glu Ile Asp 
             340                345                350
Ser Ile Leu Gly Asn Lys Pro Tyr Ser Lys Lys Asp Tyr Arg Ser 
         355                360                365



<210> 10042
<211> 1104
<212> DNA
<213> Homo sapiens
<308> AF029749
<400> 10042

atgtatcca  aatcaacga  gggctcccc  gctcggctc  cgctgcggc  gacgggctc  60
cccgggatg  tctacagta  tcggtatgg  agtcccaaa  gacagctcc  gttttacag  120
aacctgggc  agtctggcc  gcgggtctc  tgcctggga  ttggaacat  ggtgacctt  180
ggaggccag  tcaccgatg  gatggcaga  cagctcatg  ccttggcct  tgataatgg  240
atcaacctc  tcgatacag  agaagtcta  gcagccggc  aggctgaag  ggtactggg  300
aacatcatt  agaagaaag  atggaggcg  tccagcctc  tcatcacca  caagatctt  360
tggggcgga  aggcggaga  ggagcgggg  ctgtccagg  agcacataa  cgaaggtct  420
aaagcttcc  tggagcgac  gcagctgga  tacgtggat  tggtgtttg  caaccgccc  480
gaccccaac  ccccgatgg  agagaccgt  cgcgccatg  cccacgtca  caaccaggg  540
atggccatg  actggggca  gtcacgctg  agctccatg  agatcatgg  ggcctactc  600
gtggcccgg  agttcaacc  gaccccgcc  atctgcgag  aggctgagt  ccacatgtt  660
cagcgtgag  aagtggagg  gcagctgcc  gagctgttc  acaagatag  agtgggcgc  720
atgacctgg  cccctctgg  ctgtggcat  gtttctggc  agtacgaca  tggcatccc  780
ccctactca  gagcctcct  gaagggcta  cagtggctg  aggacaaga  cctcagtga  840
gagggccgg  gccagcaag  caagctgaa  gagctgcag  ccatcgccg  gcgcctggg  900
tgcaccctg  cccagctgg  catagcctg  tgcctgagg  atgagggag  cagctccgt  960
ctcctgggg  cctccaatg  ggaccagct  atggagaac  ttggggcaa  acaggtcct  1020
ccgaaactg  cgtcttcca  tatccacga  attgatagt  ttttgggca  taaacccta  1080
agcaaaaag  actacagat  ctaa  1104



<210> 10043
<211> 367
<212> PRT
<213> Homo sapiens
<308> Q13303
<400> 10043

Met Tyr Pro Glu Ser Thr Thr Gly Ser Pro Ala Arg Leu Ser Leu Arg 
  1               5                  10                  15
Gln Thr Gly Ser Pro Gly Met Ile Tyr Ser Thr Arg Tyr Gly Ser Pro 
             20                  25                  30
Lys Arg Gln Leu Gln Phe Tyr Arg Asn Leu Gly Lys Ser Gly Leu Arg 
         35                  40                  45
Val Ser Cys Leu Gly Leu Gly Thr Trp Val Thr Phe Gly Gly Gln Ile 
     50                  55                  60
Thr Asp Glu Met Ala Glu Gln Leu Met Thr Leu Ala Tyr Asp Asn Gly 
 65                  70                  75                  80
Ile Asn Leu Phe Asp Thr Ala Glu Val Tyr Ala Ala Gly Lys Ala Glu 
                 85                  90                  95
Val Val Leu Gly Asn Ile Ile Lys Lys Lys Gly Trp Arg Arg Ser Ser 
             100                105                110
Leu Val Ile Thr Thr Lys Ile Phe Trp Gly Gly Lys Ala Glu Thr Glu 
         115                120                125
Arg Gly Leu Ser Arg Lys His Ile Ile Glu Gly Leu Lys Ala Ser Leu 
     130                135                140
Glu Arg Leu Gln Leu Glu Tyr Val Asp Val Val Phe Ala Asn Arg Pro 
 145                150                155                160
Asp Pro Asn Thr Pro Met Glu Glu Thr Val Arg Ala Met Thr His Val 
                 165                170                175
Ile Asn Gln Gly Met Ala Met Tyr Trp Gly Thr Ser Arg Trp Ser Ser 
             180                185                190
Met Glu Ile Met Glu Ala Tyr Ser Val Ala Arg Gln Phe Asn Leu Thr 
         195                200                205
Pro Pro Ile Cys Glu Gln Ala Glu Tyr His Met Phe Gln Arg Glu Lys 
     210                215                220
Val Glu Val Gln Leu Pro Glu Leu Phe His Lys Ile Gly Val Gly Ala 
 225                230                235                240
Met Thr Trp Ser Pro Leu Ala Cys Gly Ile Val Ser Gly Lys Tyr Asp 
                 245                250                255
Ser Gly Ile Pro Pro Tyr Ser Arg Ala Ser Leu Lys Gly Tyr Gln Trp 
             260                265                270
Leu Lys Asp Lys Ile Leu Ser Glu Glu Gly Arg Arg Gln Gln Ala Lys 
         275                280                285
Leu Lys Glu Leu Gln Ala Ile Ala Glu Arg Leu Gly Cys Thr Leu Pro 
     290                295                300
Gln Leu Ala Ile Ala Trp Cys Leu Arg Asn Glu Gly Val Ser Ser Val 
 305                310                315                320
Leu Leu Gly Ala Ser Asn Ala Asp Gln Leu Met Glu Asn Ile Gly Ala 
                 325                330                335
Ile Gln Val Leu Pro Lys Leu Ser Ser Ser Ile Ile His Glu Ile Asp 
             340                345                350
Ser Ile Leu Gly Asn Lys Pro Tyr Ser Lys Lys Asp Tyr Arg Ser 
         355                360                365



<210> 10044
<211> 2725
<212> DNA
<213> Rattus norvegicus
<308> X76988
<400> 10044

aagcaggct  cgccgtggc  ggccccaca  tgggctggg  aaggattgg  cacggtgac  60
gccgccccg  ggccagcac  atgaagtgc  cccttcgag  gtggttcct  tctatggcc  120
tcctgctgg  gttcattat  tctctgctc  tcacgtact  acaccacag  atggctacc  180
tgccctacc  ggactcggg  actctgggc  gaacacacc  agtgaagct  gtaccgggc  240
atactgggc  acagcgcct  gtcaaggag  ggctttcgg  gaaaagttg  acctgcagt  300
gctgcatgg  tgatgccgg  acctctgag  ggtttgaca  ccactttga  agtaacatc  360
cacctgtct  gacgagaga  aacatgaac  tcaccccgg  tgtccagcg  tggtggatg  420
tgctgcaac  ccaattcaa  tcacacaac  ccaatgaag  gctggagaa  ctcttccag  480
tcgtgcccg  tgagaaccc  taccgcttc  gggaccccc  gcagtgccg  cgctgtgct  540
tggtcggga  ctcaggcaa  cttcggggc  ctggctatg  gcaagaagt  gacagccac  600
actttatca  gaggatgaa  caggcaccg  ctgtaggct  tgagaagga  gttggcagc  660
gaacaactc  ccatttcat  tacccggag  gtgccaaga  cctgcctgc  aacgtgagc  720
ttgtgctgg  gcccttcaa  gccctggac  tgatgtgga  tgccagcgc  ctctccaca  780
gacagatcc  attcaccta  gctccagtg  agtccttcc  tcgagtgga  aaagagaag  840
tccagattt  caacccagc  ttcttcaag  acatccatg  caggtggac  gagcaccat  900
gccgctacc  ctccacagg  atgctggtg  tcttctttg  actacacgt  tgtgatgag  960
tgaacgtgt  tgggttcgg  gccgacagc  gtggcaact  gcaccacta  tgggagaac  1020
accggtacg  gggcgagtt  cggaagaca  gcgtgcatg  tgccgactt  gaagcccac  1080
tcattgaca  tctggccaa  gccagcaag  ttgaagtct  ccgagggaa  tgagcagcc  1140
caggcgcct  cagaaccag  cacttcagg  tctggcaag  gccggttgc  gcccaccaa  1200
cagactgcg  cgtccccag  aaccaatca  tgctgcagt  gggaggagc  tctttctta  1260
ccaatcaca  aactcaagg  gaacttccg  cgccgccgt  tccaccaat  atggccttg  1320
gaggcggcg  gcctggacc  cctccccca  cccccaacc  ccaaccccg  tttggatga  1380
aatttttct  ctttttaag  ggccggtct  ggtctggga  ggagcacct  gaactgctc  1440
tttccagct  agtcccgat  ggtgagtga  gcccgccaa  gaaatgtgg  cccggcgag  1500
tactttcca  ggcattctg  ggctcacca  ctagtaggg  gttgtattc  ctccctagt  1560
gggttaact  attaagaat  ggaaattat  atgtggaca  tgaagggaa  tgttttctg  1620
ggcctgagg  attcactga  gccctttct  ccaaatgaa  ctcaacttt  acctaggtc  1680
agtcatgca  atagcttcc  gttgtaacc  gattcttga  tcaccagcc  tttaggagc  1740
ggaaagtag  ttagaacag  cgagtaagc  tggtaaagg  gcggacagg  ggagccatg  1800
atggcagat  ccaatctgc  cctccccag  aaagctccg  gccatctgc  aggcctgca  1860
acaactgtc  agcgatctt  gttggatag  catccctgg  agctggagg  taactaaag  1920
atgaatcca  agcaaatcc  acacccaag  aagaggctg  ctgctcctc  ttggggtga  1980
aatgaaaga  aaagataca  gcacagggc  ctcctttcc  gcctactgt  caaccctgc  2040
gctctcgcc  tagggctaa  gacttgggc  gcgtgtgtg  gagcacaag  agcggagtc  2100
cggtggtct  attttgtct  caaatcaac  ggtgagctg  agaggagac  caggaccta  2160
ggacagacg  tgagaaggt  gtggggaac  ggagtgagg  cacacgtga  agaagcacc  2220
tgcatgtga  ccggtggag  ttcctaccc  ttcctgaca  taatgaggc  ctagggagg  2280
cgacattaa  aagcagctt  ctggttggg  gacagtcac  cgtaaggag  gtgttaaag  2340
ttggtatga  gcaagtacc  ctaaaaact  atatatgaa  aactttgct  gaatttgtt  2400
cttccaagt  tcaaaagca  gggtagaga  aaagggagt  taccgagaa  ggctgtagc  2460
gaacctctc  gggctctaa  catcgtgca  tcactgtac  agtggccgt  cttgcctgt  2520
tccgctctc  caagaagct  ctgtgatga  aagtgggaa  gtactgcga  tacgacaaa  2580
agtattgag  agaagaatt  atttttcct  cttttgttt  gcttaaacc  tgagtcacc  2640
ttctagaaa  ggtaggtcc  agcacccac  tcctttttc  tctacagtt  tttaaacat  2700
caatttttc  ctctgtttc  tttcc  2725



<210> 10045
<211> 350
<212> PRT
<213> Rattus norvegicus
<308> Q11205
<400> 10045

Met Lys Cys Ser Leu Arg Val Trp Phe Leu Ser Met Ala Phe Leu Leu 
  1               5                  10                  15
Val Phe Ile Met Ser Leu Leu Phe Thr Tyr Ser His His Ser Met Ala 
             20                  25                  30
Thr Leu Pro Tyr Leu Asp Ser Gly Thr Leu Gly Gly Thr His Arg Val 
         35                  40                  45
Lys Leu Val Pro Gly Tyr Thr Gly Gln Gln Arg Leu Val Lys Glu Gly 
     50                  55                  60
Leu Ser Gly Lys Ser Cys Thr Cys Ser Arg Cys Met Gly Asp Ala Gly 
 65                  70                  75                  80
Thr Ser Glu Trp Phe Asp Ser His Phe Asp Ser Asn Ile Ser Pro Val 
                 85                  90                  95
Trp Thr Arg Asp Asn Met Asn Leu Thr Pro Asp Val Gln Arg Trp Trp 
             100                105                110
Met Met Leu Gln Pro Gln Phe Lys Ser His Asn Thr Asn Glu Val Leu 
         115                120                125
Glu Lys Leu Phe Gln Ile Val Pro Gly Glu Asn Pro Tyr Arg Phe Arg 
     130                135                140
Asp Pro Gln Gln Cys Arg Arg Cys Ala Val Val Gly Asn Ser Gly Asn 
 145                150                155                160
Leu Arg Gly Ser Gly Tyr Gly Gln Glu Val Asp Ser His Asn Phe Ile 
                 165                170                175
Met Arg Met Asn Gln Ala Pro Thr Val Gly Phe Glu Lys Asp Val Gly 
             180                185                190
Ser Arg Thr Thr His His Phe Met Tyr Pro Glu Ser Ala Lys Asn Leu 
         195                200                205
Pro Ala Asn Val Ser Phe Val Leu Val Pro Phe Lys Ala Leu Asp Leu 
     210                215                220
Met Trp Ile Ala Ser Ala Leu Ser Thr Gly Gln Ile Arg Phe Thr Tyr 
 225                230                235                240
Ala Pro Val Lys Ser Phe Leu Arg Val Asp Lys Glu Lys Val Gln Ile 
                 245                250                255
Tyr Asn Pro Ala Phe Phe Lys Tyr Ile His Asp Arg Trp Thr Glu His 
             260                265                270
His Gly Arg Tyr Pro Ser Thr Gly Met Leu Val Leu Phe Phe Ala Leu 
         275                280                285
His Val Cys Asp Glu Val Asn Val Tyr Gly Phe Gly Ala Asp Ser Arg 
     290                295                300
Gly Asn Trp His His Tyr Trp Glu Asn Asn Arg Tyr Ala Gly Glu Phe 
 305                310                315                320
Arg Lys Thr Gly Val His Asp Ala Asp Phe Glu Ala His Ile Ile Asp 
                 325                330                335
Ile Leu Ala Lys Ala Ser Lys Ile Glu Val Tyr Arg Gly Asn 
             340                345                350



<210> 10046
<211> 1623
<212> DNA
<213> Homo sapiens
<308> X96667
<400> 10046

accagggtg  caggagagg  agagcctct  tggcctagc  agtgacgga  agacccgat  60
aagccctaa  caggggccc  gcctgactc  gggacagga  agccactcc  gccaacgtg  120
gttctccct  catgaggga  ggcgtggca  gggacccct  ccactgtcc  ctgctgcag  180
acgtgcccc  atgcccttt  catgtggtg  cagaatagg  aggctacgc  gtggctggc  240
cctcagcgg  ctgggaaaa  agtggccac  gtgaccgtc  cccgcctgc  ggcaccatg  300
agtgctccc  gcgggtgtg  ttcctctcc  tggccttcc  gctggtgtt  atcatgtcc  360
tgctcttca  ctactcgca  cacagcatg  ccacgctcc  ctacctgga  tcaggggcc  420
tggatggga  gcaccgggt  aagctggtg  ccggctatg  cggcctgca  cgcctcagc  480
aggagaggc  ctcgggcaa  agctgtgcc  gtcgccgct  catgggcga  gccggtgcc  540
ccgactggt  tgacagcca  tttgacggt  acatttccc  cgtctggac  cgagagaac  600
tggatcttc  accggacgt  cagaggtgg  ggatgatgc  gcagcccca  ttcaagtca  660
acaacacca  tgaggtgct  gagaagctg  tccagatag  gcctggcga  aacccctac  720
gcttccggg  cccccacca  tgccggcgc  gtgccgtgg  ggggaactc  ggcaacctg  780
ggggctctg  ctatgggca  gacgtggac  ggcacaact  catcatgag  atgaatcag  840
cgccaaccg  gggctttga  caggatgtt  gcagccgaa  cacccacca  ttcatgtac  900
ctgagagtg  caagaacct  cccgccaac  tcagcttcg  gctggtgcc  ttcaaggtc  960
tggaccttc  gtggatcgc  agcgccttg  ccacggggc  gatccgatt  acctacgcc  1020
cagtgaagt  cttccttcg  gtggataaa  aaaaggtcc  gatctacaa  ccagccttc  1080
tcaagtata  ccacgacag  tggacagag  atcacgggc  gtacccttc  acggggatg  1140
tggtgcttt  ctttgccct  catgtgtgt  atgaggtga  cgtgtacgg  ttcggggcc  1200
acagccggg  caactggca  cactactgg  agaacaacc  gtacgcggg  gagttccgg  1260
agactggcg  gcacgacgc  gacttcgag  cccacatca  cgacatgct  gccaaggcc  1320
gcaagatcg  agtctaccg  ggcaactga  ccgggcctc  ccgcgaccc  tccggccca  1380
ctatcgggc  ccggggctc  ggcccggga  ccaggacca  caacccgcg  ccaatcatg  1440
tgcagccca  gggcgtctg  tgtgccccg  caatcacga  actggggga  cggccgggc  1500
tggcaccaa  ctgcgctgc  gtcgggcgg  gcttctgtt  ctcccagcc  atcatgtga  1560
tcaaggaaa  cttccggcg  tgtgtccag  ctcctccaa  caatggcct  cgggggcgg  1620
cca  1623



<210> 10047
<211> 350
<212> PRT
<213> Homo sapiens
<308> NP_008858
<400> 10047

Met Lys Cys Ser Leu Arg Val Trp Phe Leu Ser Val Ala Phe Leu Leu 
  1               5                  10                  15
Val Phe Ile Met Ser Leu Leu Phe Thr Tyr Ser His His Ser Met Ala 
             20                  25                  30
Thr Leu Pro Tyr Leu Asp Ser Gly Ala Leu Asp Gly Thr His Arg Val 
         35                  40                  45
Lys Leu Val Pro Gly Tyr Ala Gly Leu Gln Arg Leu Ser Lys Glu Arg 
     50                  55                  60
Leu Ser Gly Lys Ser Cys Ala Cys Arg Arg Cys Met Gly Asp Ala Gly 
 65                  70                  75                  80
Ala Ser Asp Trp Phe Asp Ser His Phe Asp Gly Asn Ile Ser Pro Val 
                 85                  90                  95
Trp Thr Arg Glu Asn Met Asp Leu Pro Pro Asp Val Gln Arg Trp Trp 
             100                105                110
Met Met Leu Gln Pro Gln Phe Lys Ser His Asn Thr Asn Glu Val Leu 
         115                120                125
Glu Lys Leu Phe Gln Ile Val Pro Gly Glu Asn Pro Tyr Arg Phe Arg 
     130                135                140
Asp Pro His Gln Cys Arg Arg Cys Ala Val Val Gly Asn Ser Gly Asn 
 145                150                155                160
Leu Arg Gly Ser Gly Tyr Gly Gln Asp Val Asp Gly His Asn Phe Ile 
                 165                170                175
Met Arg Met Asn Gln Ala Pro Thr Val Gly Phe Glu Gln Asp Val Gly 
             180                185                190
Ser Arg Thr Thr His His Phe Met Tyr Pro Glu Ser Ala Lys Asn Leu 
         195                200                205
Pro Ala Asn Val Ser Phe Val Leu Val Pro Phe Lys Val Leu Asp Leu 
     210                215                220
Leu Trp Ile Ala Ser Ala Leu Ser Thr Gly Gln Ile Arg Phe Thr Tyr 
 225                230                235                240
Ala Pro Val Lys Ser Phe Leu Arg Val Asp Lys Glu Lys Val Gln Ile 
                 245                250                255
Tyr Asn Pro Ala Phe Phe Lys Tyr Ile His Asp Arg Trp Thr Glu His 
             260                265                270
His Gly Arg Tyr Pro Ser Thr Gly Met Leu Val Leu Phe Phe Ala Leu 
         275                280                285
His Val Cys Asp Glu Val Asn Val Tyr Gly Phe Gly Ala Asp Ser Arg 
     290                295                300
Gly Asn Trp His His Tyr Trp Glu Asn Asn Arg Tyr Ala Gly Glu Phe 
 305                310                315                320
Arg Lys Thr Gly Val His Asp Ala Asp Phe Glu Ala His Ile Ile Asp 
                 325                330                335
Met Leu Ala Lys Ala Ser Lys Ile Glu Val Tyr Arg Gly Asn 
             340                345                350



<210> 10048
<211> 1973
<212> DNA
<213> Rattus norvegicus
<308> X77237
<400> 10048

tcgctttgc  gcatggcga  ggcggaggg  gagcggact  agtgtgctg  gcccccccg  60
gacgaaccc  cggccgaag  cactctgaa  cgggcagag  agctcaaga  acaggccaa  120
gactacttc  aagccaagg  ctacgagaa  gctatcaag  tctacagtc  ggccatcga  180
ttgaacccc  gcaatgcca  ctactatgg  aaccgcagc  tggcctacc  gcgcaccga  240
tgctatggc  atgcactgg  cgatgccac  cgggctatc  agcttgaca  gaagtacat  300
aaaggttac  accgccggg  ggctagcaa  atggcactg  gcaagttcc  ggctgccct  360
cgtgactac  agacggtgg  gaaggtgaa  cctaatgac  aggatgcca  gatgaagta  420
caggagtgc  gcaagattg  gaagcagaa  gcctttgag  gggccattg  aggcgacga  480
cacagacgc  ctgtcgtgg  ctctctgga  atcgaaagc  tgaccattg  agatgaata  540
agtgggccc  agcttgagg  tggcaaagt  acaatcacc  tcatgaaag  cctcatgca  600
tggtacaag  atcagaaga  actgcaccg  aagtgcgcc  accagatcc  agtgcaggt  660
aaggaagtc  tctgcaagc  gagcacgct  gtggagaca  cgctgaaag  gacagagaa  720
attacagtg  gtggggaca  ccatggcca  ttttatgac  tcctcaaca  atttgagct  780
aacggttta  cctcagaga  caaccccta  atatttaac  gcgactttg  ggaccgtgg  840
tccttctcc  ttgaagtga  cctcaccct  tttggcttc  agctcctgt  tccagatca  900
tttcatcta  ttcgaggca  ccacgagac  gacaacatg  accagatct  tggcttcga  960
ggcgaggtg  aggccaagt  cacagccca  atgtatgag  tcttcagcg  ggtgttcga  1020
tggcttccg  tggcacagt  tatcaatgg  aaagtgctg  tcatgcatg  aggcctatt  1080
agcgaagat  gtgtcactc  ggatgacat  cggaagatt  agcggaatc  gcagccccc  1140
gactcaggt  ccatgtgtg  cctgctgtg  tcagatccc  agccacaga  tgggcgctc  1200
gtcagcaag  gtggtgtga  ttgtcagtt  gggcccgat  tcaccaagg  cttcctgga  1260
gagaatcaa  tggactaca  catccgcag  catgaagtc  aagctgagg  ctacgaggt  1320
gcccatggt  gccgctgtg  caccgtctt  tctgccccc  attattgtg  ccagatggg  1380
aacaaagcc  cctacatcc  cctccaggg  tccgacctg  ggccccagt  ccaccaatt  1440
acagcagtg  ctcacccca  cgtcaagcc  atggcatac  ccaacacgc  gctgcagct  1500
ggaatgatg  gaggcagtc  acagcagta  ccagggcct  cacagctgg  gggccccgc  1560
ttcggcctg  tgccccgcc  cagggcagc  ttggacccc  ttttacttt  taaagtttg  1620
atttattcc  ctttaggtt  cagaggggg  gggggcagc  tggggcagc  gacgacagg  1680
tcctggtca  agaaaggag  agttgaaat  gggggtagg  cacagcctg  gcatttgga  1740
gaaggccaa  ctgggtagg  gtagggccg  gaggaggtc  tgccccctc  cctgcatgg  1800
tcctcccct  gtaaagcaa  aggaccctg  cataggaag  ccccaaaag  gggtcatca  1860
ggaggcctc  tcctggtag  ctcagggtg  ggcgaggct  gggcccacc  cccagctat  1920
ttatgttct  taattaaat  tgttaaaat  aaataaagt  attattgta  gtc  1973



<210> 10049
<211> 499
<212> PRT
<213> Rattus norvegicus
<308> P53042
<400> 10049

Met Ala Met Ala Glu Gly Glu Arg Thr Glu Cys Ala Glu Pro Pro Arg 
  1               5                  10                  15
Asp Glu Pro Pro Ala Glu Gly Thr Leu Lys Arg Ala Glu Glu Leu Lys 
             20                  25                  30
Thr Gln Ala Asn Asp Tyr Phe Lys Ala Lys Asp Tyr Glu Asn Ala Ile 
         35                  40                  45
Lys Phe Tyr Ser Gln Ala Ile Glu Leu Asn Pro Ser Asn Ala Ile Tyr 
     50                  55                  60
Tyr Gly Asn Arg Ser Leu Ala Tyr Leu Arg Thr Glu Cys Tyr Gly Tyr 
 65                  70                  75                  80
Ala Leu Gly Asp Ala Thr Arg Ala Ile Glu Leu Asp Lys Lys Tyr Ile 
                 85                  90                  95
Lys Gly Tyr Tyr Arg Arg Ala Ala Ser Asn Met Ala Leu Gly Lys Phe 
             100                105                110
Arg Ala Ala Leu Arg Asp Tyr Glu Thr Val Val Lys Val Lys Pro Asn 
         115                120                125
Asp Lys Asp Ala Lys Met Lys Tyr Gln Glu Cys Ser Lys Ile Val Lys 
     130                135                140
Gln Lys Ala Phe Glu Arg Ala Ile Ala Gly Asp Glu His Arg Arg Ser 
 145                150                155                160
Val Val Asp Ser Leu Asp Ile Glu Ser Met Thr Ile Glu Asp Glu Tyr 
                 165                170                175
Ser Gly Pro Lys Leu Glu Asp Gly Lys Val Thr Ile Thr Phe Met Lys 
             180                185                190
Asp Leu Met Gln Trp Tyr Lys Asp Gln Lys Lys Leu His Arg Lys Cys 
         195                200                205
Ala Tyr Gln Ile Leu Val Gln Val Lys Glu Val Leu Cys Lys Leu Ser 
     210                215                220
Thr Leu Val Glu Thr Thr Leu Lys Glu Thr Glu Lys Ile Thr Val Cys 
 225                230                235                240
Gly Asp Thr His Gly Gln Phe Tyr Asp Leu Leu Asn Ile Phe Glu Leu 
                 245                250                255
Asn Gly Leu Pro Ser Glu Thr Asn Pro Tyr Ile Phe Asn Gly Asp Phe 
             260                265                270
Val Asp Arg Gly Ser Phe Ser Val Glu Val Ile Leu Thr Leu Phe Gly 
         275                280                285
Phe Lys Leu Leu Tyr Pro Asp His Phe His Leu Leu Arg Gly Asn His 
     290                295                300
Glu Thr Asp Asn Met Asn Gln Ile Tyr Gly Phe Glu Gly Glu Val Lys 
 305                310                315                320
Ala Lys Tyr Thr Ala Gln Met Tyr Glu Leu Phe Ser Glu Val Phe Glu 
                 325                330                335
Trp Leu Pro Leu Ala Gln Cys Ile Asn Gly Lys Val Leu Ile Met His 
             340                345                350
Gly Gly Leu Phe Ser Glu Asp Gly Val Thr Leu Asp Asp Ile Arg Lys 
         355                360                365
Ile Glu Arg Asn Arg Gln Pro Pro Asp Ser Gly Pro Met Cys Asp Leu 
     370                375                380
Leu Trp Ser Asp Pro Gln Pro Gln Asn Gly Arg Ser Val Ser Lys Arg 
 385                390                395                400
Gly Val Ser Cys Gln Phe Gly Pro Asp Val Thr Lys Ala Phe Leu Glu 
                 405                410                415
Glu Asn Gln Leu Asp Tyr Ile Ile Arg Ser His Glu Val Lys Ala Glu 
             420                425                430
Gly Tyr Glu Val Ala His Gly Gly Arg Cys Val Thr Val Phe Ser Ala 
         435                440                445
Pro Asn Tyr Cys Asp Gln Met Gly Asn Lys Ala Ser Tyr Ile His Leu 
     450                455                460
Gln Gly Ser Asp Leu Arg Pro Gln Phe His Gln Phe Thr Ala Val Pro 
 465                470                475                480
His Pro Asn Val Lys Pro Met Ala Tyr Ala Asn Thr Leu Leu Gln Leu 
                 485                490                495
Gly Met Met 
             500



<210> 10050
<211> 2075
<212> DNA
<213> Homo sapiens
<308> BC001970
<400> 10050

cgcgacggt  cggccgggt  ccgctggcg  ccgttgcca  ggtaggggt  gctttgcgg  60
atggcgatg  cggagggcg  gaggactga  tgtgctgag  ccccccggg  cgaaccccc  120
gctgatgga  ctctgaagc  ggcagagga  ctcaagact  aggccaatg  ctacttcaa  180
gccaaggac  acgagaacg  catcaagtt  tacagccag  ccatcgagc  gaaccccag  240
aatgccatc  actatggca  ccgcagcct  gcctacctg  gcactgagt  ctatggcta  300
gcgctggga  acgccacgc  ggccattga  ctggacaag  agtacatca  gggttatta  360
cgccgggct  ccagcaaca  ggcactggg  aagttccgg  ccgcgctgc  agactacga  420
acggtggtc  aggtgaagc  ccatgacaa  gatgccaaa  tgaaatacc  ggagtgcaa  480
aagatcgtg  agcagaagg  ctttgagcg  gccatcgcg  gcgacgagc  caagcgctc  540
gtggtggac  cgctggaca  cgagagcat  accattgag  atgagtaca  cggacccaa  600
cttgaagac  gcaaagtga  aatcagttt  atgaaggag  tcatgcagt  gtacaagga  660
cagaagaaa  tgcaccgga  atgtgccta  cagattctg  tacaggtca  agaggtcct  720
tccaagctg  gcacgctcg  ggaaaccac  ctcaaagag  cagagaaga  tacagtatg  780
ggggacacc  atggccagt  ctatgacct  ctcaacata  tcgagctca  cggtttacc  840
tcggagacc  acccctata  atttaatgg  gactttgtg  accgaggct  cttctctgt  900
gaagtgatc  tcacccttt  cggcttcaa  ctcctgtac  cagatcact  tcacctcct  960
cgaggcaac  acgagacag  caacatgaa  cagatctac  gtttcgagg  tgaggtgaa  1020
gccaagtac  cagcccaga  gtacgagct  tttagcgag  tgttcgagt  gctcccgtt  1080
gcccagtgc  tcaacggca  agtgctgat  atgcacgga  gcctgttca  tgaagacgg  1140
gtcaccctg  atgacatcc  gaaaattga  cggaatcga  aacccccag  ttcagggcc  1200
atgtgtgac  tgctctggt  agatccaca  ccacagaac  ggcgctcga  cagcaagcg  1260
ggcgtgagc  gtcagtttg  gcctgacgt  accaaggcc  tcttggaag  gaacaacct  1320
gactatatc  tccgcagcc  cgaagtcaa  gccgagggc  acgaggtgg  tcacggagg  1380
cgctgtgtc  ccgtcttct  tgcccccaa  tactgcgac  agatgggga  caaagcctc  1440
tacatccac  tccagggct  tgacctacg  cctcagttc  accagttca  agcagtgcc  1500
catcccaac  tcaagccca  ggcctatgc  aacacgctg  tgcagctag  aatgatgtg  1560
ggtgacggg  ggggcggcc  gcatcccag  gcccctcca  tcccaccgg  cccaggccc  1620
gggctaggg  cagagcagg  cccgcccca  ggcaatgtt  gaccccctt  tactttgta  1680
agtttgtat  tattcccct  taggtttgc  gagggggta  gggcagagt  aggggctgg  1740
cagagggtc  gctccctgg  cagagagga  ggaggtgga  cagctgggg  tgggggcac  1800
gcctgggca  tctgtgggg  ggccgtcct  ggggtgggg  ggggccgag  ggctgccct  1860
cccccctca  ttgcatggc  cctccccca  tcaagcaat  gggccccgc  ataggaaga  1920
ccccagaga  agggtcagc  ggggggccc  gcctgcgcc  cccctccta  agccccatg  1980
tggggctag  ctggggctc  cccccctcc  cagctattt  atgtctgta  ttaaatatg  2040
taaaataaa  tcattatcg  aaaaaaaaa  aaaaa  2075



<210> 10051
<211> 499
<212> PRT
<213> Homo sapiens
<308> P53041
<400> 10051

Met Ala Met Ala Glu Gly Glu Arg Thr Glu Cys Ala Glu Pro Pro Arg 
  1               5                  10                  15
Asp Glu Pro Pro Ala Asp Gly Ala Leu Lys Arg Ala Glu Glu Leu Lys 
             20                  25                  30
Thr Gln Ala Asn Asp Tyr Phe Lys Ala Lys Asp Tyr Glu Asn Ala Ile 
         35                  40                  45
Lys Phe Tyr Ser Gln Ala Ile Glu Leu Asn Pro Ser Asn Ala Ile Tyr 
     50                  55                  60
Tyr Gly Asn Arg Ser Leu Ala Tyr Leu Arg Thr Glu Cys Tyr Gly Tyr 
 65                  70                  75                  80
Ala Leu Gly Asp Ala Thr Arg Ala Ile Glu Leu Asp Lys Lys Tyr Ile 
                 85                  90                  95
Lys Gly Tyr Tyr Arg Arg Ala Ala Ser Asn Met Ala Leu Gly Lys Phe 
             100                105                110
Arg Ala Ala Leu Arg Asp Tyr Glu Thr Val Val Lys Val Lys Pro His 
         115                120                125
Asp Lys Asp Ala Lys Met Lys Tyr Gln Glu Cys Asn Lys Ile Val Lys 
     130                135                140
Gln Lys Ala Phe Glu Arg Ala Ile Ala Gly Asp Glu His Lys Arg Ser 
 145                150                155                160
Val Val Asp Ser Leu Asp Ile Glu Ser Met Thr Ile Glu Asp Glu Tyr 
                 165                170                175
Ser Gly Pro Lys Leu Glu Asp Gly Lys Val Thr Ile Ser Phe Met Lys 
             180                185                190
Glu Leu Met Gln Trp Tyr Lys Asp Gln Lys Lys Leu His Arg Lys Cys 
         195                200                205
Ala Tyr Gln Ile Leu Val Gln Val Lys Glu Val Leu Ser Lys Leu Ser 
     210                215                220
Thr Leu Val Glu Thr Thr Leu Lys Glu Thr Glu Lys Ile Thr Val Cys 
 225                230                235                240
Gly Asp Thr His Gly Gln Phe Tyr Asp Leu Leu Asn Ile Phe Glu Leu 
                 245                250                255
Asn Gly Leu Pro Ser Glu Thr Asn Pro Tyr Ile Phe Asn Gly Asp Phe 
             260                265                270
Val Asp Arg Gly Ser Phe Ser Val Glu Val Ile Leu Thr Leu Phe Gly 
         275                280                285
Phe Lys Leu Leu Tyr Pro Asp His Phe His Leu Leu Arg Gly Asn His 
     290                295                300
Glu Thr Asp Asn Met Asn Gln Ile Tyr Gly Phe Glu Gly Glu Val Lys 
 305                310                315                320
Ala Lys Tyr Thr Ala Gln Met Tyr Glu Leu Phe Ser Glu Val Phe Glu 
                 325                330                335
Trp Leu Pro Leu Ala Gln Cys Ile Asn Gly Lys Val Leu Ile Met His 
             340                345                350
Gly Gly Leu Phe Ser Glu Asp Gly Val Thr Leu Asp Asp Ile Arg Lys 
         355                360                365
Ile Glu Arg Asn Arg Gln Pro Pro Asp Ser Gly Pro Met Cys Asp Leu 
     370                375                380
Leu Trp Ser Asp Pro Gln Pro Gln Asn Gly Arg Ser Ile Ser Lys Arg 
 385                390                395                400
Gly Val Ser Cys Gln Phe Gly Pro Asp Val Thr Lys Ala Phe Leu Glu 
                 405                410                415
Glu Asn Asn Leu Asp Tyr Ile Ile Arg Ser His Glu Val Lys Ala Glu 
             420                425                430
Gly Tyr Glu Val Ala His Gly Gly Arg Cys Val Thr Val Phe Ser Ala 
         435                440                445
Pro Asn Tyr Cys Asp Gln Met Gly Asn Lys Ala Ser Tyr Ile His Leu 
     450                455                460
Gln Gly Ser Asp Leu Arg Pro Gln Phe His Gln Phe Thr Ala Val Pro 
 465                470                475                480
His Pro Asn Val Lys Pro Met Ala Tyr Ala Asn Thr Leu Leu Gln Leu 
                 485                490                495
Gly Met Met 
             500



<210> 10052
<211> 1969
<212> DNA
<213> Rattus norvegicus
<308> X77934
<400> 10052

agacgcttc  gggtcgcgt  agggagacg  tctggtccg  ttgtgcgtg  gaggaggag  60
gcccagcgc  acagcgacc  ggagaggga  ggcggccac  gggaccgcg  ccgctgcgg  120
caccggcaa  cttcttgtc  tgctgctgc  cgggctcac  gcacccgca  cggctctgg  180
tggctatat  gaggctctc  cagccaatg  tggaacagg  tttgcggtt  ctgaacctc  240
gattgcgat  ttctgtggg  agctgaaca  gcatgtgaa  attcagact  ggaagtggg  300
gcctgaccc  accggcacc  agagctgcc  gggaacaaa  gaggaagtt  ttcagtact  360
ccaggagat  tatccagag  tgcagatca  aaatgtgat  gaagcaaac  agccagtca  420
tattgatag  tggtgccga  gggacaaaa  acagtgcag  agtcacatt  ttataccat  480
caagtgtct  gtgggtgaa  ttgtaagtg  tgttctgct  gttccagaa  actgccagt  540
tttccacca  gagcggatg  aggtgtgtg  gaagcatca  cggtggcac  cagtcgtca  600
ggaggcatg  ctgactgag  ggatgacct  atatagcta  ggcatgctg  tgccctgtg  660
ggtagacca  ttccatggc  ctgagtatg  gtgctgccc  cagacaaag  ttgttgact  720
tgactccac  atgtccaaa  aagaggagg  agaagagga  gaggatgaa  aagaagact  780
tgctcttga  aaaagtgaa  ttcctaccg  agcagatct  gaagacttc  cagaagcag  840
tgcagatga  gacgaggat  aggaggagg  ggaggagga  gaaggggag  aagtggtag  900
agaccgtga  tactactat  actccttta  aggagatga  tacaatgag  agaacccaa  960
tgaacccag  agcgatggc  ccatctcag  caaggagat  gctcacgat  ttaaagctg  1020
ctgctccca  gaggccatg  cggggccct  ccgggccgt  atgcctcgt  ggtacttcg  1080
cctctccaa  ggaaagtgc  tacgcttta  atatggcgg  tgcggcggc  acaggaaca  1140
ttttgagtc  gaggattat  gtatggctg  gtgtaaaac  atgattccc  cgactcccc  1200
gccaaccaa  gatgtggac  tgtattttg  gacgtcggc  gatgacaat  agcacgccc  1260
ctttcagaa  gctaaggag  agttggaaa  tcggcatcg  agccgaatg  acagggtaa  1320
aaaggagtg  gaagaagca  aacttcaag  caagaacct  cccaaggca  agcgacaga  1380
cctcattca  catttccaa  ctatggtta  agccttaga  aaggaagca  ccagtgaga  1440
gcagcagct  gtggagacc  atttggccc  agtagaagc  atgctgaat  accgtcggc  1500
catagctct  gaaaactac  tggctgccc  gcagtctga  cctcctcgg  cacatcgca  1560
tcttcaagc  cttcgtcgt  acgtccgtg  tgagaacaa  gatcgcctg  acaccattc  1620
tcattacca  catgtgttg  ctgttgacc  agaaaaggc  gcgcagatg  aatcccagg  1680
gatgacaca  ctccatgtc  ttgaagaaa  aaggaacca  agtctctct  tgctgtaca  1740
agtgcctta  gtggctcaa  agattcagg  ggaaattga  gagctcctt  aggaacagc  1800
agcagatat  gaccagttt  cctcctcca  ctcagagaa  cctgtggat  tccgggtga  1860
ctctgagga  agtgaggag  tcccgccgt  ccacccttt  catcccttc  catccttgt  1920
tgagaacga  gacactcag  cggagttgt  ccacccaat  aaaaaagga  1969



<210> 10053
<211> 765
<212> PRT
<213> Rattus norvegicus
<308> CAA54906
<400> 10053

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Lys Leu Leu 
  1               5                  10                  15
Val Leu Leu Leu Leu Gly Leu Thr Ala Pro Ala Ala Ala Leu Ala Gly 
             20                  25                  30
Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
         35                  40                  45
Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
     50                  55                  60
Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
 65                  70                  75                  80
Leu Gly Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Ile Tyr Pro 
                 85                  90                  95
Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Pro Val Asn Ile 
             100                105                110
Asp Ser Trp Cys Arg Arg Asp Lys Lys Gln Cys Arg Ser His Ile Val 
         115                120                125
Ile Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
     130                135                140
Val Pro Glu Asn Cys Gln Phe Phe His Gln Glu Arg Met Glu Val Cys 
 145                150                155                160
Glu Lys His Gln Arg Trp His Thr Val Val Lys Glu Ala Cys Leu Thr 
                 165                170                175
Glu Gly Met Thr Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
             180                185                190
Asp Gln Phe His Gly Thr Glu Tyr Val Cys Cys Pro Gln Thr Lys Val 
         195                200                205
Val Asp Ser Asp Ser Thr Met Ser Lys Glu Glu Glu Glu Glu Glu Glu 
     210                215                220
Glu Asp Glu Glu Glu Asp Tyr Ala Leu Asp Lys Ser Glu Phe Pro Thr 
 225                230                235                240
Glu Ala Asp Leu Glu Asp Phe Thr Glu Ala Ala Ala Asp Glu Asp Glu 
                 245                250                255
Asp Glu Glu Glu Glu Glu Glu Glu Glu Gly Glu Glu Val Val Glu Asp 
             260                265                270
Arg Asp Tyr Tyr Tyr Asp Ser Phe Lys Gly Asp Asp Tyr Asn Glu Glu 
         275                280                285
Asn Pro Thr Glu Pro Ser Ser Asp Gly Thr Ile Ser Asp Lys Glu Ile 
     290                295                300
Ala His Asp Val Lys Ala Val Cys Ser Gln Glu Ala Met Thr Gly Pro 
 305                310                315                320
Cys Arg Ala Val Met Pro Arg Trp Tyr Phe Asp Leu Ser Lys Gly Lys 
                 325                330                335
Cys Val Arg Phe Ile Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe 
             340                345                350
Glu Ser Glu Asp Tyr Cys Met Ala Val Cys Lys Thr Met Ile Pro Pro 
         355                360                365
Thr Pro Leu Pro Thr Asn Asp Val Asp Val Tyr Phe Glu Thr Ser Ala 
     370                375                380
Asp Asp Asn Glu His Ala Arg Phe Gln Lys Ala Lys Glu Gln Leu Glu 
 385                390                395                400
Ile Arg His Arg Ser Arg Met Asp Arg Val Lys Lys Glu Trp Glu Glu 
                 405                410                415
Ala Glu Leu Gln Ala Lys Asn Leu Pro Lys Ala Glu Arg Gln Thr Leu 
             420                425                430
Ile Gln His Phe Gln Ala Met Val Lys Ala Leu Glu Lys Glu Ala Ala 
         435                440                445
Ser Glu Lys Gln Gln Leu Val Glu Thr His Leu Ala Arg Val Glu Ala 
     450                455                460
Met Leu Asn Asp Arg Arg Arg Ile Ala Leu Glu Asn Tyr Leu Ala Ala 
 465                470                475                480
Leu Gln Ser Asp Pro Pro Arg Pro His Arg Ile Leu Gln Ala Leu Arg 
                 485                490                495
Arg Tyr Val Arg Ala Glu Asn Lys Asp Arg Leu His Thr Ile Arg His 
             500                505                510
Tyr Gln His Val Leu Ala Val Asp Pro Glu Lys Ala Ala Gln Met Lys 
         515                520                525
Ser Gln Val Met Thr His Leu His Val Ile Glu Glu Arg Arg Asn Gln 
     530                535                540
Ser Leu Ser Leu Leu Tyr Lys Val Pro Tyr Val Ala Gln Glu Ile Gln 
 545                550                555                560
Glu Glu Ile Asp Glu Leu Leu Gln Glu Gln Arg Ala Asp Met Asp Gln 
                 565                570                575
Phe Thr Ser Ser Ile Ser Glu Asn Pro Val Asp Val Arg Val Ser Ser 
             580                585                590
Glu Glu Ser Glu Glu Ile Pro Pro Phe His Pro Phe His Pro Phe Pro 
         595                600                605
Ser Leu Ser Glu Asn Glu Asp Thr Gln Pro Glu Leu Tyr His Pro Met 
     610                615                620
Lys Lys Gly Ser Gly Met Ala Glu Gln Asp Gly Gly Leu Ile Gly Ala 
 625                630                635                640
Glu Glu Lys Val Ile Asn Ser Lys Asn Lys Met Asp Glu Asn Met Val 
                 645                650                655
Ile Asp Glu Thr Leu Asp Val Lys Glu Met Ile Phe Asn Ala Glu Arg 
             660                665                670
Val Gly Gly Leu Glu Glu Glu Pro Asp Ser Val Gly Pro Leu Arg Glu 
         675                680                685
Asp Phe Ser Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val Ile Ala 
     690                695                700
Val Ala Ile Ala Thr Val Ile Val Ile Ser Leu Val Met Leu Arg Lys 
 705                710                715                720
Arg Gln Tyr Gly Thr Ile Ser His Gly Ile Val Glu Val His Pro Met 
                 725                730                735
Leu Thr Pro Glu Glu Arg His Leu Asn Lys Met Gln Asn His Gly Tyr 
             740                745                750
Glu Asn Pro Thr Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
         755                760                765



<210> 10054
<211> 3727
<212> DNA
<213> Homo sapiens
<308> NM_001642
<400> 10054

gtcgcggtg  gctaagcga  gagtccgag  gtgtgagct  gagagccgc  cgctagagc  60
acccggcga  ggatggcgg  caccgggac  gcggccgcc  cagccacgg  caggctcct  120
cttctgctg  tggtggggc  cacggcgcc  gccttggcg  tggccggct  catcgaggc  180
cttgcagcc  atgccggaa  aggatttgc  gttgctgag  ctcaaatcg  aatgttttg  240
gggaagtta  atatgcatg  gaacattca  actgggaaa  gggaacctg  tccaacagg  300
accaagagc  gctttgaaa  aaaagaaga  gttcttcag  actgtcagg  gatgtatcc  360
gagctacag  tcacaaatg  gatggaggc  aaccagcgg  ttagtattg  caactggtg  420
cggagggac  aaaagcaat  caagagtcg  tttgttaca  ctttcaagt  tctcgtggg  480
gaatttgta  gtgatgtcc  gctagttcc  gaaaagtgc  agtttttcc  caaagagcg  540
atggaggtg  gtgagaatc  ccagcactg  cacacggta  tcaaagagg  atgtctgac  600
cagggaatg  ccttatata  ctacggcat  ctgctccca  gtggggtag  ccagttcca  660
ggcactgaa  atgtgtgct  ccctcagac  aagattatt  gatctgtgt  aaaagaaga  720
gaagaggaa  atgaagagg  agaggaaga  gaagatgaa  aggaagact  tgatgttta  780
aaaagtgaa  ttcctactg  agcagatct  gaagacttc  cagaagcag  tgtggatga  840
gatgatgag  atgaggaag  aggggagga  gtggtggag  accgagatt  ctactatga  900
accttcaaa  gagatgact  caatgagga  aatcctact  aacccggca  cgacggcac  960
atgtcagac  aggaaatta  tcatgatgt  aaagctgtc  gctcccagg  ggcgatgac  1020
gggccctgc  gggccgtga  gcctcgttg  tacttcgac  tctccaagg  aaagtgcgt  1080
cgctttata  atggtggct  cggcggcaa  aggaacaat  ttgagtctg  ggattattg  1140
atggctgtg  gtaaagcga  gattcctcc  actcctctg  caaccaatg  tgttgatgt  1200
tatttcgag  cctctgcag  tgataatga  catgctcgc  tccagaagg  taaggagca  1260
ctggagatt  ggcaccgca  ccgaatgga  agggtaaag  aggaatggg  agaggcaga  1320
cttcaagct  agaacctcc  caaagcaga  aggcagact  tgattcagc  cttccaagc  1380
atggttaaa  ctttagaga  ggaagcagc  agtgagaag  agcagctgg  ggagaccca  1440
ctggcccga  tggaagcta  gctgaatga  cgccgtcgg  tggctctgg  gaactacct  1500
gctgccttg  agtctgacc  gccacggcc  catcgcatt  tccaggcct  acggcgtta  1560
gtccgtgct  agaacaaag  tcgcttaca  accatccgt  attaccagc  tgtgttggc  1620
gttgaccca  aaaaggcgg  ccagatgaa  tcccaggtg  tgacacatc  ccacgtgat  1680
gaagaaagg  ggaaccaaa  cctctctct  ctctacaaa  taccttatg  agcccaaga  1740
attcaagag  aaattgatg  gctccttca  gagcagcgt  cagatatgg  ccagttcac  1800
gcctcaatc  cagagaccc  tgtggacgt  cgggtgagc  ctgaggaga  tgaggagat  1860
ccaccgttc  accccttcc  ccccttccc  gccctacct  agaacgaag  cactcagcc  1920
gagttgtac  acccaatga  aaaaggatc  ggagtggga  agcaggatg  gggactgat  1980
ggtgccgaa  agaaagtga  taacagtaa  aataaagtg  atgaaaaca  ggtcattga  2040
gagactctg  atgttaagg  aatgatttt  aatgccgag  gagttggag  cctcgagga  2100
gagcgggaa  ccgtgggcc  actgcggga  gacttcagt  tgagtagca  tgctctcat  2160
ggcctgctg  tcatcgcag  ggccattgc  acggtcatc  tcatcagcc  ggtgatgct  2220
aggaagagg  agtatggca  catcagcca  gggatcgtg  aggttgatc  aatgctcac  2280
ccagaagag  gtcacctga  caagatgca  aaccatggc  atgagaacc  cacctacaa  2340
tacctggag  agatgcaga  ttaggtggc  gggagcgcg  cagccctgg  ggagggatg  2400
aggtgggcc  gaagatccc  cgattccga  cgactgcca  gcagcagcc  ctgccaggg  2460
ctgcgtctg  catcctgac  tcctggact  taggactat  taaagtact  ctgtagaac  2520
gcaatttcc  ttcttttaa  tgggtgaaa  atggtaata  aacaatata  gatatataa  2580
ccttaaatg  aaaaaatga  ctattgcag  tatttgatg  agttttctt  tttaaatta  2640
tcagaaacc  cacttccat  gtattgtct  acacatgct  tcaatatat  ataaatggg  2700
aatgtcgat  ttcaataat  gacttatat  caggctgtc  ttccggtta  gttgtgtaa  2760
tcaactctt  agcctcatt  actgtcctg  cttttattt  aagaaaaaa  aggcagtat  2820
cccttttta  atgagcttt  aggaagttg  tgagaaatg  ggtggaata  ggaactgta  2880
tggccactg  agcacgtga  agaccctcg  aaaatgatg  gaaaggacc  gtttcttga  2940
gtccagtgt  tccacggct  gatacctgt  tgtctccat  aaagtcctg  caccaagga  3000
gttaaaggc  ttttattcc  gcgtcttct  gagagctta  tgtatacag  tgagggtgt  3060
cgctgctgc  ttccttcgg  atccagtgc  tccacagag  ttagcctgt  gcttatatt  3120
gacattctt  actgtctgt  gtttaccta  cgtagcttt  taccgttca  ttccccttc  3180
aactatgtc  agatgtgca  gctcctcct  tctggactt  ctccaaagg  actgaccct  3240
ggcctctac  ttgtcccct  acctccacc  cctcctgtc  ccggccttg  gacattcac  3300
cagagaaga  cacaccaag  aggggccgc  gctggccca  gagagaaca  ggggaggtt  3360
gtttgtgtg  aaggaaagt  gtccaggct  tccctgaaa  tgagtctgt  gacactgtg  3420
aaagctttg  acaattgtg  tttcgtcac  ggagtcttt  taatgcttg  acagttgat  3480
tcgatgctc  ctgcttctg  tttttcttt  tttttattt  aaaaaatct  aaggttctg  3540
taacctgtg  tgtattttt  ttttcctgt  actgttttt  ttttgtttt  ttccttttt  3600
ctccccttt  gccctattc  tgtctctac  cactatgca  agattaaac  tcacctaca  3660
actccttaa  atgatctgt  gagaatgta  acagtttaa  cacatcaat  aatacttta  3720
cttccaa  3727



<210> 10055
<211> 763
<212> PRT
<213> Homo sapiens
<308> Q06481
<400> 10055

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
  1               5                  10                  15
Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
             20                  25                  30
Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
         35                  40                  45
Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
     50                  55                  60
Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
 65                  70                  75                  80
Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                 85                  90                  95
Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
             100                105                110
Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
         115                120                125
Thr Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
     130                135                140
Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val Cys 
 145                150                155                160
Glu Asn His Gln His Trp His Thr Val Val Lys Glu Ala Cys Leu Thr 
                 165                170                175
Gln Gly Met Thr Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
             180                185                190
Asp Gln Phe His Gly Thr Glu Tyr Val Cys Cys Pro Gln Thr Lys Ile 
         195                200                205
Ile Gly Ser Val Ser Lys Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
     210                215                220
Glu Glu Glu Asp Glu Glu Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe 
 225                230                235                240
Pro Thr Glu Ala Asp Leu Glu Asp Phe Thr Glu Ala Ala Val Asp Glu 
                 245                250                255
Asp Asp Glu Asp Glu Glu Glu Gly Glu Glu Val Val Glu Asp Arg Asp 
             260                265                270
Tyr Tyr Tyr Asp Thr Phe Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro 
         275                280                285
Thr Glu Pro Gly Ser Asp Gly Thr Met Ser Asp Lys Glu Ile Thr His 
     290                295                300
Asp Val Lys Ala Val Cys Ser Gln Glu Ala Met Thr Gly Pro Cys Arg 
 305                310                315                320
Ala Val Met Pro Arg Trp Tyr Phe Asp Leu Ser Lys Gly Lys Cys Val 
                 325                330                335
Arg Phe Ile Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Glu Ser 
             340                345                350
Glu Asp Tyr Cys Met Ala Val Cys Lys Ala Met Ile Pro Pro Thr Pro 
         355                360                365
Leu Pro Thr Asn Asp Val Asp Val Tyr Phe Glu Thr Ser Ala Asp Asp 
     370                375                380
Asn Glu His Ala Arg Phe Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg 
 385                390                395                400
His Arg Asn Arg Met Asp Arg Val Lys Lys Glu Trp Glu Glu Ala Glu 
                 405                410                415
Leu Gln Ala Lys Asn Leu Pro Lys Ala Glu Arg Gln Thr Leu Ile Gln 
             420                425                430
His Phe Gln Ala Met Val Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu 
         435                440                445
Lys Gln Gln Leu Val Glu Thr His Leu Ala Arg Val Glu Ala Met Leu 
     450                455                460
Asn Asp Arg Arg Arg Met Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln 
 465                470                475                480
Ser Asp Pro Pro Arg Pro His Arg Ile Leu Gln Ala Leu Arg Arg Tyr 
                 485                490                495
Val Arg Ala Glu Asn Lys Asp Arg Leu His Thr Ile Arg His Tyr Gln 
             500                505                510
His Val Leu Ala Val Asp Pro Glu Lys Ala Ala Gln Met Lys Ser Gln 
         515                520                525
Val Met Thr His Leu His Val Ile Glu Glu Arg Arg Asn Gln Ser Leu 
     530                535                540
Ser Leu Leu Tyr Lys Val Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu 
 545                550                555                560
Ile Asp Glu Leu Leu Gln Glu Gln Arg Ala Asp Met Asp Gln Phe Thr 
                 565                570                575
Ala Ser Ile Ser Glu Thr Pro Val Asp Val Arg Val Ser Ser Glu Glu 
             580                585                590
Ser Glu Glu Ile Pro Pro Phe His Pro Phe His Pro Phe Pro Ala Leu 
         595                600                605
Pro Glu Asn Glu Asp Thr Gln Pro Glu Leu Tyr His Pro Met Lys Lys 
     610                615                620
Gly Ser Gly Val Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu 
 625                630                635                640
Lys Val Ile Asn Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp 
                 645                650                655
Glu Thr Leu Asp Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly 
             660                665                670
Gly Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe 
         675                680                685
Ser Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala 
     690                695                700
Ile Ala Thr Val Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln 
 705                710                715                720
Tyr Gly Thr Ile Ser His Gly Ile Val Glu Val Asp Pro Met Leu Thr 
                 725                730                735
Pro Glu Glu Arg His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn 
             740                745                750
Pro Thr Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
         755                760



<210> 10056
<211> 1969
<212> DNA
<213> Rattus norvegicus
<308> X77934
<400> 10056

agacgcttc  gggtcgcgt  agggagacg  tctggtccg  ttgtgcgtg  gaggaggag  60
gcccagcgc  acagcgacc  ggagaggga  ggcggccac  gggaccgcg  ccgctgcgg  120
caccggcaa  cttcttgtc  tgctgctgc  cgggctcac  gcacccgca  cggctctgg  180
tggctatat  gaggctctc  cagccaatg  tggaacagg  tttgcggtt  ctgaacctc  240
gattgcgat  ttctgtggg  agctgaaca  gcatgtgaa  attcagact  ggaagtggg  300
gcctgaccc  accggcacc  agagctgcc  gggaacaaa  gaggaagtt  ttcagtact  360
ccaggagat  tatccagag  tgcagatca  aaatgtgat  gaagcaaac  agccagtca  420
tattgatag  tggtgccga  gggacaaaa  acagtgcag  agtcacatt  ttataccat  480
caagtgtct  gtgggtgaa  ttgtaagtg  tgttctgct  gttccagaa  actgccagt  540
tttccacca  gagcggatg  aggtgtgtg  gaagcatca  cggtggcac  cagtcgtca  600
ggaggcatg  ctgactgag  ggatgacct  atatagcta  ggcatgctg  tgccctgtg  660
ggtagacca  ttccatggc  ctgagtatg  gtgctgccc  cagacaaag  ttgttgact  720
tgactccac  atgtccaaa  aagaggagg  agaagagga  gaggatgaa  aagaagact  780
tgctcttga  aaaagtgaa  ttcctaccg  agcagatct  gaagacttc  cagaagcag  840
tgcagatga  gacgaggat  aggaggagg  ggaggagga  gaaggggag  aagtggtag  900
agaccgtga  tactactat  actccttta  aggagatga  tacaatgag  agaacccaa  960
tgaacccag  agcgatggc  ccatctcag  caaggagat  gctcacgat  ttaaagctg  1020
ctgctccca  gaggccatg  cggggccct  ccgggccgt  atgcctcgt  ggtacttcg  1080
cctctccaa  ggaaagtgc  tacgcttta  atatggcgg  tgcggcggc  acaggaaca  1140
ttttgagtc  gaggattat  gtatggctg  gtgtaaaac  atgattccc  cgactcccc  1200
gccaaccaa  gatgtggac  tgtattttg  gacgtcggc  gatgacaat  agcacgccc  1260
ctttcagaa  gctaaggag  agttggaaa  tcggcatcg  agccgaatg  acagggtaa  1320
aaaggagtg  gaagaagca  aacttcaag  caagaacct  cccaaggca  agcgacaga  1380
cctcattca  catttccaa  ctatggtta  agccttaga  aaggaagca  ccagtgaga  1440
gcagcagct  gtggagacc  atttggccc  agtagaagc  atgctgaat  accgtcggc  1500
catagctct  gaaaactac  tggctgccc  gcagtctga  cctcctcgg  cacatcgca  1560
tcttcaagc  cttcgtcgt  acgtccgtg  tgagaacaa  gatcgcctg  acaccattc  1620
tcattacca  catgtgttg  ctgttgacc  agaaaaggc  gcgcagatg  aatcccagg  1680
gatgacaca  ctccatgtc  ttgaagaaa  aaggaacca  agtctctct  tgctgtaca  1740
agtgcctta  gtggctcaa  agattcagg  ggaaattga  gagctcctt  aggaacagc  1800
agcagatat  gaccagttt  cctcctcca  ctcagagaa  cctgtggat  tccgggtga  1860
ctctgagga  agtgaggag  tcccgccgt  ccacccttt  catcccttc  catccttgt  1920
tgagaacga  gacactcag  cggagttgt  ccacccaat  aaaaaagga  1969



<210> 10057
<211> 765
<212> PRT
<213> Rattus norvegicus
<308> CAA54906
<400> 10057

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Lys Leu Leu 
  1               5                  10                  15
Val Leu Leu Leu Leu Gly Leu Thr Ala Pro Ala Ala Ala Leu Ala Gly 
             20                  25                  30
Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
         35                  40                  45
Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
     50                  55                  60
Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
 65                  70                  75                  80
Leu Gly Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Ile Tyr Pro 
                 85                  90                  95
Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Pro Val Asn Ile 
             100                105                110
Asp Ser Trp Cys Arg Arg Asp Lys Lys Gln Cys Arg Ser His Ile Val 
         115                120                125
Ile Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
     130                135                140
Val Pro Glu Asn Cys Gln Phe Phe His Gln Glu Arg Met Glu Val Cys 
 145                150                155                160
Glu Lys His Gln Arg Trp His Thr Val Val Lys Glu Ala Cys Leu Thr 
                 165                170                175
Glu Gly Met Thr Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
             180                185                190
Asp Gln Phe His Gly Thr Glu Tyr Val Cys Cys Pro Gln Thr Lys Val 
         195                200                205
Val Asp Ser Asp Ser Thr Met Ser Lys Glu Glu Glu Glu Glu Glu Glu 
     210                215                220
Glu Asp Glu Glu Glu Asp Tyr Ala Leu Asp Lys Ser Glu Phe Pro Thr 
 225                230                235                240
Glu Ala Asp Leu Glu Asp Phe Thr Glu Ala Ala Ala Asp Glu Asp Glu 
                 245                250                255
Asp Glu Glu Glu Glu Glu Glu Glu Glu Gly Glu Glu Val Val Glu Asp 
             260                265                270
Arg Asp Tyr Tyr Tyr Asp Ser Phe Lys Gly Asp Asp Tyr Asn Glu Glu 
         275                280                285
Asn Pro Thr Glu Pro Ser Ser Asp Gly Thr Ile Ser Asp Lys Glu Ile 
     290                295                300
Ala His Asp Val Lys Ala Val Cys Ser Gln Glu Ala Met Thr Gly Pro 
 305                310                315                320
Cys Arg Ala Val Met Pro Arg Trp Tyr Phe Asp Leu Ser Lys Gly Lys 
                 325                330                335
Cys Val Arg Phe Ile Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe 
             340                345                350
Glu Ser Glu Asp Tyr Cys Met Ala Val Cys Lys Thr Met Ile Pro Pro 
         355                360                365
Thr Pro Leu Pro Thr Asn Asp Val Asp Val Tyr Phe Glu Thr Ser Ala 
     370                375                380
Asp Asp Asn Glu His Ala Arg Phe Gln Lys Ala Lys Glu Gln Leu Glu 
 385                390                395                400
Ile Arg His Arg Ser Arg Met Asp Arg Val Lys Lys Glu Trp Glu Glu 
                 405                410                415
Ala Glu Leu Gln Ala Lys Asn Leu Pro Lys Ala Glu Arg Gln Thr Leu 
             420                425                430
Ile Gln His Phe Gln Ala Met Val Lys Ala Leu Glu Lys Glu Ala Ala 
         435                440                445
Ser Glu Lys Gln Gln Leu Val Glu Thr His Leu Ala Arg Val Glu Ala 
     450                455                460
Met Leu Asn Asp Arg Arg Arg Ile Ala Leu Glu Asn Tyr Leu Ala Ala 
 465                470                475                480
Leu Gln Ser Asp Pro Pro Arg Pro His Arg Ile Leu Gln Ala Leu Arg 
                 485                490                495
Arg Tyr Val Arg Ala Glu Asn Lys Asp Arg Leu His Thr Ile Arg His 
             500                505                510
Tyr Gln His Val Leu Ala Val Asp Pro Glu Lys Ala Ala Gln Met Lys 
         515                520                525
Ser Gln Val Met Thr His Leu His Val Ile Glu Glu Arg Arg Asn Gln 
     530                535                540
Ser Leu Ser Leu Leu Tyr Lys Val Pro Tyr Val Ala Gln Glu Ile Gln 
 545                550                555                560
Glu Glu Ile Asp Glu Leu Leu Gln Glu Gln Arg Ala Asp Met Asp Gln 
                 565                570                575
Phe Thr Ser Ser Ile Ser Glu Asn Pro Val Asp Val Arg Val Ser Ser 
             580                585                590
Glu Glu Ser Glu Glu Ile Pro Pro Phe His Pro Phe His Pro Phe Pro 
         595                600                605
Ser Leu Ser Glu Asn Glu Asp Thr Gln Pro Glu Leu Tyr His Pro Met 
     610                615                620
Lys Lys Gly Ser Gly Met Ala Glu Gln Asp Gly Gly Leu Ile Gly Ala 
 625                630                635                640
Glu Glu Lys Val Ile Asn Ser Lys Asn Lys Met Asp Glu Asn Met Val 
                 645                650                655
Ile Asp Glu Thr Leu Asp Val Lys Glu Met Ile Phe Asn Ala Glu Arg 
             660                665                670
Val Gly Gly Leu Glu Glu Glu Pro Asp Ser Val Gly Pro Leu Arg Glu 
         675                680                685
Asp Phe Ser Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val Ile Ala 
     690                695                700
Val Ala Ile Ala Thr Val Ile Val Ile Ser Leu Val Met Leu Arg Lys 
 705                710                715                720
Arg Gln Tyr Gly Thr Ile Ser His Gly Ile Val Glu Val His Pro Met 
                 725                730                735
Leu Thr Pro Glu Glu Arg His Leu Asn Lys Met Gln Asn His Gly Tyr 
             740                745                750
Glu Asn Pro Thr Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
         755                760                765



<210> 10058
<211> 3727
<212> DNA
<213> Homo sapiens
<308> NM_001642
<400> 10058

gtcgcggtg  gctaagcga  gagtccgag  gtgtgagct  gagagccgc  cgctagagc  60
acccggcga  ggatggcgg  caccgggac  gcggccgcc  cagccacgg  caggctcct  120
cttctgctg  tggtggggc  cacggcgcc  gccttggcg  tggccggct  catcgaggc  180
cttgcagcc  atgccggaa  aggatttgc  gttgctgag  ctcaaatcg  aatgttttg  240
gggaagtta  atatgcatg  gaacattca  actgggaaa  gggaacctg  tccaacagg  300
accaagagc  gctttgaaa  aaaagaaga  gttcttcag  actgtcagg  gatgtatcc  360
gagctacag  tcacaaatg  gatggaggc  aaccagcgg  ttagtattg  caactggtg  420
cggagggac  aaaagcaat  caagagtcg  tttgttaca  ctttcaagt  tctcgtggg  480
gaatttgta  gtgatgtcc  gctagttcc  gaaaagtgc  agtttttcc  caaagagcg  540
atggaggtg  gtgagaatc  ccagcactg  cacacggta  tcaaagagg  atgtctgac  600
cagggaatg  ccttatata  ctacggcat  ctgctccca  gtggggtag  ccagttcca  660
ggcactgaa  atgtgtgct  ccctcagac  aagattatt  gatctgtgt  aaaagaaga  720
gaagaggaa  atgaagagg  agaggaaga  gaagatgaa  aggaagact  tgatgttta  780
aaaagtgaa  ttcctactg  agcagatct  gaagacttc  cagaagcag  tgtggatga  840
gatgatgag  atgaggaag  aggggagga  gtggtggag  accgagatt  ctactatga  900
accttcaaa  gagatgact  caatgagga  aatcctact  aacccggca  cgacggcac  960
atgtcagac  aggaaatta  tcatgatgt  aaagctgtc  gctcccagg  ggcgatgac  1020
gggccctgc  gggccgtga  gcctcgttg  tacttcgac  tctccaagg  aaagtgcgt  1080
cgctttata  atggtggct  cggcggcaa  aggaacaat  ttgagtctg  ggattattg  1140
atggctgtg  gtaaagcga  gattcctcc  actcctctg  caaccaatg  tgttgatgt  1200
tatttcgag  cctctgcag  tgataatga  catgctcgc  tccagaagg  taaggagca  1260
ctggagatt  ggcaccgca  ccgaatgga  agggtaaag  aggaatggg  agaggcaga  1320
cttcaagct  agaacctcc  caaagcaga  aggcagact  tgattcagc  cttccaagc  1380
atggttaaa  ctttagaga  ggaagcagc  agtgagaag  agcagctgg  ggagaccca  1440
ctggcccga  tggaagcta  gctgaatga  cgccgtcgg  tggctctgg  gaactacct  1500
gctgccttg  agtctgacc  gccacggcc  catcgcatt  tccaggcct  acggcgtta  1560
gtccgtgct  agaacaaag  tcgcttaca  accatccgt  attaccagc  tgtgttggc  1620
gttgaccca  aaaaggcgg  ccagatgaa  tcccaggtg  tgacacatc  ccacgtgat  1680
gaagaaagg  ggaaccaaa  cctctctct  ctctacaaa  taccttatg  agcccaaga  1740
attcaagag  aaattgatg  gctccttca  gagcagcgt  cagatatgg  ccagttcac  1800
gcctcaatc  cagagaccc  tgtggacgt  cgggtgagc  ctgaggaga  tgaggagat  1860
ccaccgttc  accccttcc  ccccttccc  gccctacct  agaacgaag  cactcagcc  1920
gagttgtac  acccaatga  aaaaggatc  ggagtggga  agcaggatg  gggactgat  1980
ggtgccgaa  agaaagtga  taacagtaa  aataaagtg  atgaaaaca  ggtcattga  2040
gagactctg  atgttaagg  aatgatttt  aatgccgag  gagttggag  cctcgagga  2100
gagcgggaa  ccgtgggcc  actgcggga  gacttcagt  tgagtagca  tgctctcat  2160
ggcctgctg  tcatcgcag  ggccattgc  acggtcatc  tcatcagcc  ggtgatgct  2220
aggaagagg  agtatggca  catcagcca  gggatcgtg  aggttgatc  aatgctcac  2280
ccagaagag  gtcacctga  caagatgca  aaccatggc  atgagaacc  cacctacaa  2340
tacctggag  agatgcaga  ttaggtggc  gggagcgcg  cagccctgg  ggagggatg  2400
aggtgggcc  gaagatccc  cgattccga  cgactgcca  gcagcagcc  ctgccaggg  2460
ctgcgtctg  catcctgac  tcctggact  taggactat  taaagtact  ctgtagaac  2520
gcaatttcc  ttcttttaa  tgggtgaaa  atggtaata  aacaatata  gatatataa  2580
ccttaaatg  aaaaaatga  ctattgcag  tatttgatg  agttttctt  tttaaatta  2640
tcagaaacc  cacttccat  gtattgtct  acacatgct  tcaatatat  ataaatggg  2700
aatgtcgat  ttcaataat  gacttatat  caggctgtc  ttccggtta  gttgtgtaa  2760
tcaactctt  agcctcatt  actgtcctg  cttttattt  aagaaaaaa  aggcagtat  2820
cccttttta  atgagcttt  aggaagttg  tgagaaatg  ggtggaata  ggaactgta  2880
tggccactg  agcacgtga  agaccctcg  aaaatgatg  gaaaggacc  gtttcttga  2940
gtccagtgt  tccacggct  gatacctgt  tgtctccat  aaagtcctg  caccaagga  3000
gttaaaggc  ttttattcc  gcgtcttct  gagagctta  tgtatacag  tgagggtgt  3060
cgctgctgc  ttccttcgg  atccagtgc  tccacagag  ttagcctgt  gcttatatt  3120
gacattctt  actgtctgt  gtttaccta  cgtagcttt  taccgttca  ttccccttc  3180
aactatgtc  agatgtgca  gctcctcct  tctggactt  ctccaaagg  actgaccct  3240
ggcctctac  ttgtcccct  acctccacc  cctcctgtc  ccggccttg  gacattcac  3300
cagagaaga  cacaccaag  aggggccgc  gctggccca  gagagaaca  ggggaggtt  3360
gtttgtgtg  aaggaaagt  gtccaggct  tccctgaaa  tgagtctgt  gacactgtg  3420
aaagctttg  acaattgtg  tttcgtcac  ggagtcttt  taatgcttg  acagttgat  3480
tcgatgctc  ctgcttctg  tttttcttt  tttttattt  aaaaaatct  aaggttctg  3540
taacctgtg  tgtattttt  ttttcctgt  actgttttt  ttttgtttt  ttccttttt  3600
ctccccttt  gccctattc  tgtctctac  cactatgca  agattaaac  tcacctaca  3660
actccttaa  atgatctgt  gagaatgta  acagtttaa  cacatcaat  aatacttta  3720
cttccaa  3727



<210> 10059
<211> 763
<212> PRT
<213> Homo sapiens
<308> Q06481
<400> 10059

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
  1               5                  10                  15
Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
             20                  25                  30
Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
         35                  40                  45
Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
     50                  55                  60
Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
 65                  70                  75                  80
Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                 85                  90                  95
Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
             100                105                110
Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
         115                120                125
Thr Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
     130                135                140
Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val Cys 
 145                150                155                160
Glu Asn His Gln His Trp His Thr Val Val Lys Glu Ala Cys Leu Thr 
                 165                170                175
Gln Gly Met Thr Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
             180                185                190
Asp Gln Phe His Gly Thr Glu Tyr Val Cys Cys Pro Gln Thr Lys Ile 
         195                200                205
Ile Gly Ser Val Ser Lys Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
     210                215                220
Glu Glu Glu Asp Glu Glu Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe 
 225                230                235                240
Pro Thr Glu Ala Asp Leu Glu Asp Phe Thr Glu Ala Ala Val Asp Glu 
                 245                250                255
Asp Asp Glu Asp Glu Glu Glu Gly Glu Glu Val Val Glu Asp Arg Asp 
             260                265                270
Tyr Tyr Tyr Asp Thr Phe Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro 
         275                280                285
Thr Glu Pro Gly Ser Asp Gly Thr Met Ser Asp Lys Glu Ile Thr His 
     290                295                300
Asp Val Lys Ala Val Cys Ser Gln Glu Ala Met Thr Gly Pro Cys Arg 
 305                310                315                320
Ala Val Met Pro Arg Trp Tyr Phe Asp Leu Ser Lys Gly Lys Cys Val 
                 325                330                335
Arg Phe Ile Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Glu Ser 
             340                345                350
Glu Asp Tyr Cys Met Ala Val Cys Lys Ala Met Ile Pro Pro Thr Pro 
         355                360                365
Leu Pro Thr Asn Asp Val Asp Val Tyr Phe Glu Thr Ser Ala Asp Asp 
     370                375                380
Asn Glu His Ala Arg Phe Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg 
 385                390                395                400
His Arg Asn Arg Met Asp Arg Val Lys Lys Glu Trp Glu Glu Ala Glu 
                 405                410                415
Leu Gln Ala Lys Asn Leu Pro Lys Ala Glu Arg Gln Thr Leu Ile Gln 
             420                425                430
His Phe Gln Ala Met Val Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu 
         435                440                445
Lys Gln Gln Leu Val Glu Thr His Leu Ala Arg Val Glu Ala Met Leu 
     450                455                460
Asn Asp Arg Arg Arg Met Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln 
 465                470                475                480
Ser Asp Pro Pro Arg Pro His Arg Ile Leu Gln Ala Leu Arg Arg Tyr 
                 485                490                495
Val Arg Ala Glu Asn Lys Asp Arg Leu His Thr Ile Arg His Tyr Gln 
             500                505                510
His Val Leu Ala Val Asp Pro Glu Lys Ala Ala Gln Met Lys Ser Gln 
         515                520                525
Val Met Thr His Leu His Val Ile Glu Glu Arg Arg Asn Gln Ser Leu 
     530                535                540
Ser Leu Leu Tyr Lys Val Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu 
 545                550                555                560
Ile Asp Glu Leu Leu Gln Glu Gln Arg Ala Asp Met Asp Gln Phe Thr 
                 565                570                575
Ala Ser Ile Ser Glu Thr Pro Val Asp Val Arg Val Ser Ser Glu Glu 
             580                585                590
Ser Glu Glu Ile Pro Pro Phe His Pro Phe His Pro Phe Pro Ala Leu 
         595                600                605
Pro Glu Asn Glu Asp Thr Gln Pro Glu Leu Tyr His Pro Met Lys Lys 
     610                615                620
Gly Ser Gly Val Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu 
 625                630                635                640
Lys Val Ile Asn Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp 
                 645                650                655
Glu Thr Leu Asp Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly 
             660                665                670
Gly Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe 
         675                680                685
Ser Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala 
     690                695                700
Ile Ala Thr Val Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln 
 705                710                715                720
Tyr Gly Thr Ile Ser His Gly Ile Val Glu Val Asp Pro Met Leu Thr 
                 725                730                735
Pro Glu Glu Arg His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn 
             740                745                750
Pro Thr Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
         755                760



<210> 10061
<211> 727
<212> PRT
<213> Rattus norvegicus
<308> P35571
<400> 10061

Met Ala Phe Gln Lys Val Val Lys Gly Thr Ile Leu Met Gly Gly Gly 
  1               5                  10                  15
Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
             20                  25                  30
Lys Gln Val Ser Leu Ala Tyr Val Glu Ala Ala Thr Cys Phe Ser Glu 
         35                  40                  45
Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Met Thr Leu 
     50                  55                  60
Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
 65                  70                  75                  80
Gly Cys Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                 85                  90                  95
Leu Val Glu Arg Asn Asp Phe Ala Ser Gly Thr Ser Ser Arg Ser Thr 
             100                105                110
Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Thr Asn 
         115                120                125
Leu Asp Val Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
     130                135                140
Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
 145                150                155                160
Met Leu Pro Leu Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                 165                170                175
Ile Lys Met Tyr Asp Leu Val Ala Gly Ser His Cys Leu Lys Ser Ser 
             180                185                190
Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
         195                200                205
Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
     210                215                220
Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
 225                230                235                240
Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                 245                250                255
Asp Pro Glu Thr Gly Lys Glu Arg Val Ser Gly Ala Arg Cys Lys Asp 
             260                265                270
Val Leu Thr Gly His Glu Phe Asn Val Arg Ala Lys Cys Val Ile Asn 
         275                280                285
Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Asn Asp 
     290                295                300
Val Val Pro Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
 305                310                315                320
Gly Tyr Tyr Ser Pro Glu Asn Met Gly Leu Leu Asp Pro Ala Thr Ser 
                 325                330                335
Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Glu Lys Met Thr Ile Ala 
             340                345                350
Gly Thr Thr Asp Ser Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
         355                360                365
Glu Asp Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
     370                375                380
Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
 385                390                395                400
Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asn Thr Gln Ser Ile 
                 405                410                415
Ser Arg Asn His Val Val Glu Val Ser Asp Ser Gly Leu Ile Thr Ile 
             420                425                430
Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Val 
         435                440                445
Asn Lys Ala Val Lys Leu His Asn Leu Asn Ala Gly Pro Ser Arg Thr 
     450                455                460
Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
 465                470                475                480
Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                 485                490                495
Leu Ala Lys Thr Tyr Gly Asp Lys Ala Phe Asp Val Ala Lys Met Ala 
             500                505                510
Ser Val Thr Gly Lys Arg Trp Pro Val Val Gly Val Arg Leu Val Ser 
         515                520                525
Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
     530                535                540
Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
 545                550                555                560
Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Lys Ile Val Glu Leu 
                 565                570                575
Met Gly Arg Glu Leu Asn Trp Ser Glu Leu Arg Lys Gln Glu Glu Leu 
             580                585                590
Glu Thr Ala Thr Arg Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
         595                600                605
Thr Glu Gln Leu Thr Asp Ser Thr Glu Ile Ser Leu Leu Pro Pro Asp 
     610                615                620
Ile Asp Arg Tyr Lys Lys Arg Phe His Met Phe Asp Glu Asp Glu Lys 
 625                630                635                640
Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                 645                650                655
Val Gln Met Asp Glu Asp Thr Leu His Glu Ile Leu Cys Glu Val Asp 
             660                665                670
Leu Asn Lys Asn Gly Gln Val Glu Leu His Glu Phe Leu Gln Leu Met 
         675                680                685
Ser Ala Val His Thr Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
     690                695                700
Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
 705                710                715                720
Asp Arg Ser Cys Gly Gly Leu 
                 725



<210> 10062
<211> 2425
<212> DNA
<213> Homo sapiens
<308> AK022596
<400> 10062

tataattat  tgttaaata  ggcac  2425



<210> 10063
<211> 727
<212> PRT
<213> Homo sapiens
<308> AAB60403
<400> 10063

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
  1               5                  10                  15
Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
             20                  25                  30
Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
         35                  40                  45
Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
     50                  55                  60
Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
 65                  70                  75                  80
Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                 85                  90                  95
Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
             100                105                110
Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys 
         115                120                125
Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
     130                135                140
Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
 145                150                155                160
Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                 165                170                175
Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser 
             180                185                190
Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
         195                200                205
Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
     210                215                220
Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
 225                230                235                240
Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                 245                250                255
Asp Pro Gln Thr Gly Lys Val His Val Ser Gly Ala Arg Cys Lys Asp 
             260                265                270
Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
         275                280                285
Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp 
     290                295                300
Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
 305                310                315                320
Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser 
                 325                330                335
Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala 
             340                345                350
Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
         355                360                365
Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
     370                375                380
Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
 385                390                395                400
Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile 
                 405                410                415
Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile Thr Ile 
             420                425                430
Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Ile 
         435                440                445
Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser Arg Thr 
     450                455                460
Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
 465                470                475                480
Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                 485                490                495
Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala 
             500                505                510
Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val His Leu Val Ser 
         515                520                525
Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
     530                535                540
Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
 545                550                555                560
Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu 
                 565                570                575
Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu Gln Leu 
             580                585                590
Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
         595                600                605
Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro Ser Asp 
     610                615                620
Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp Gln Lys 
 625                630                635                640
Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                 645                650                655
Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp 
             660                665                670
Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met 
         675                680                685
Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
     690                695                700
Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
 705                710                715                720
Asp Arg Ser Cys Gly Gly Leu 
                 725



<210> 10065
<211> 727
<212> PRT
<213> Rattus norvegicus
<308> P35571
<400> 10065

Met Ala Phe Gln Lys Val Val Lys Gly Thr Ile Leu Met Gly Gly Gly 
  1               5                  10                  15
Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
             20                  25                  30
Lys Gln Val Ser Leu Ala Tyr Val Glu Ala Ala Thr Cys Phe Ser Glu 
         35                  40                  45
Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Met Thr Leu 
     50                  55                  60
Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
 65                  70                  75                  80
Gly Cys Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                 85                  90                  95
Leu Val Glu Arg Asn Asp Phe Ala Ser Gly Thr Ser Ser Arg Ser Thr 
             100                105                110
Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Thr Asn 
         115                120                125
Leu Asp Val Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
     130                135                140
Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
 145                150                155                160
Met Leu Pro Leu Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                 165                170                175
Ile Lys Met Tyr Asp Leu Val Ala Gly Ser His Cys Leu Lys Ser Ser 
             180                185                190
Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
         195                200                205
Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
     210                215                220
Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
 225                230                235                240
Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                 245                250                255
Asp Pro Glu Thr Gly Lys Glu Arg Val Ser Gly Ala Arg Cys Lys Asp 
             260                265                270
Val Leu Thr Gly His Glu Phe Asn Val Arg Ala Lys Cys Val Ile Asn 
         275                280                285
Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Asn Asp 
     290                295                300
Val Val Pro Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
 305                310                315                320
Gly Tyr Tyr Ser Pro Glu Asn Met Gly Leu Leu Asp Pro Ala Thr Ser 
                 325                330                335
Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Glu Lys Met Thr Ile Ala 
             340                345                350
Gly Thr Thr Asp Ser Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
         355                360                365
Glu Asp Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
     370                375                380
Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
 385                390                395                400
Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asn Thr Gln Ser Ile 
                 405                410                415
Ser Arg Asn His Val Val Glu Val Ser Asp Ser Gly Leu Ile Thr Ile 
             420                425                430
Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Val 
         435                440                445
Asn Lys Ala Val Lys Leu His Asn Leu Asn Ala Gly Pro Ser Arg Thr 
     450                455                460
Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
 465                470                475                480
Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                 485                490                495
Leu Ala Lys Thr Tyr Gly Asp Lys Ala Phe Asp Val Ala Lys Met Ala 
             500                505                510
Ser Val Thr Gly Lys Arg Trp Pro Val Val Gly Val Arg Leu Val Ser 
         515                520                525
Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
     530                535                540
Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
 545                550                555                560
Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Lys Ile Val Glu Leu 
                 565                570                575
Met Gly Arg Glu Leu Asn Trp Ser Glu Leu Arg Lys Gln Glu Glu Leu 
             580                585                590
Glu Thr Ala Thr Arg Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
         595                600                605
Thr Glu Gln Leu Thr Asp Ser Thr Glu Ile Ser Leu Leu Pro Pro Asp 
     610                615                620
Ile Asp Arg Tyr Lys Lys Arg Phe His Met Phe Asp Glu Asp Glu Lys 
 625                630                635                640
Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                 645                650                655
Val Gln Met Asp Glu Asp Thr Leu His Glu Ile Leu Cys Glu Val Asp 
             660                665                670
Leu Asn Lys Asn Gly Gln Val Glu Leu His Glu Phe Leu Gln Leu Met 
         675                680                685
Ser Ala Val His Thr Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
     690                695                700
Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
 705                710                715                720
Asp Arg Ser Cys Gly Gly Leu 
                 725



<210> 10066
<211> 2425
<212> DNA
<213> Homo sapiens
<308> AK022596
<400> 10066

tataattat  tgttaaata  ggcac  2425



<210> 10067
<211> 727
<212> PRT
<213> Homo sapiens
<308> AAB60403
<400> 10067

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
  1               5                  10                  15
Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
             20                  25                  30
Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
         35                  40                  45
Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
     50                  55                  60
Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
 65                  70                  75                  80
Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                 85                  90                  95
Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
             100                105                110
Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys 
         115                120                125
Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
     130                135                140
Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
 145                150                155                160
Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                 165                170                175
Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser 
             180                185                190
Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
         195                200                205
Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
     210                215                220
Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
 225                230                235                240
Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                 245                250                255
Asp Pro Gln Thr Gly Lys Val His Val Ser Gly Ala Arg Cys Lys Asp 
             260                265                270
Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
         275                280                285
Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp 
     290                295                300
Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
 305                310                315                320
Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser 
                 325                330                335
Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala 
             340                345                350
Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
         355                360                365
Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
     370                375                380
Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
 385                390                395                400
Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile 
                 405                410                415
Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile Thr Ile 
             420                425                430
Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Ile 
         435                440                445
Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser Arg Thr 
     450                455                460
Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
 465                470                475                480
Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                 485                490                495
Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala 
             500                505                510
Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val His Leu Val Ser 
         515                520                525
Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
     530                535                540
Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
 545                550                555                560
Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu 
                 565                570                575
Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu Gln Leu 
             580                585                590
Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
         595                600                605
Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro Ser Asp 
     610                615                620
Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp Gln Lys 
 625                630                635                640
Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                 645                650                655
Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp 
             660                665                670
Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met 
         675                680                685
Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
     690                695                700
Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
 705                710                715                720
Asp Arg Ser Cys Gly Gly Leu 
                 725



<210> 10069
<211> 727
<212> PRT
<213> Rattus norvegicus
<308> P35571
<400> 10069

Met Ala Phe Gln Lys Val Val Lys Gly Thr Ile Leu Met Gly Gly Gly 
  1               5                  10                  15
Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
             20                  25                  30
Lys Gln Val Ser Leu Ala Tyr Val Glu Ala Ala Thr Cys Phe Ser Glu 
         35                  40                  45
Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Met Thr Leu 
     50                  55                  60
Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
 65                  70                  75                  80
Gly Cys Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                 85                  90                  95
Leu Val Glu Arg Asn Asp Phe Ala Ser Gly Thr Ser Ser Arg Ser Thr 
             100                105                110
Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Thr Asn 
         115                120                125
Leu Asp Val Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
     130                135                140
Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
 145                150                155                160
Met Leu Pro Leu Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                 165                170                175
Ile Lys Met Tyr Asp Leu Val Ala Gly Ser His Cys Leu Lys Ser Ser 
             180                185                190
Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
         195                200                205
Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
     210                215                220
Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
 225                230                235                240
Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                 245                250                255
Asp Pro Glu Thr Gly Lys Glu Arg Val Ser Gly Ala Arg Cys Lys Asp 
             260                265                270
Val Leu Thr Gly His Glu Phe Asn Val Arg Ala Lys Cys Val Ile Asn 
         275                280                285
Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Asn Asp 
     290                295                300
Val Val Pro Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
 305                310                315                320
Gly Tyr Tyr Ser Pro Glu Asn Met Gly Leu Leu Asp Pro Ala Thr Ser 
                 325                330                335
Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Glu Lys Met Thr Ile Ala 
             340                345                350
Gly Thr Thr Asp Ser Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
         355                360                365
Glu Asp Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
     370                375                380
Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
 385                390                395                400
Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asn Thr Gln Ser Ile 
                 405                410                415
Ser Arg Asn His Val Val Glu Val Ser Asp Ser Gly Leu Ile Thr Ile 
             420                425                430
Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Val 
         435                440                445
Asn Lys Ala Val Lys Leu His Asn Leu Asn Ala Gly Pro Ser Arg Thr 
     450                455                460
Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
 465                470                475                480
Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                 485                490                495
Leu Ala Lys Thr Tyr Gly Asp Lys Ala Phe Asp Val Ala Lys Met Ala 
             500                505                510
Ser Val Thr Gly Lys Arg Trp Pro Val Val Gly Val Arg Leu Val Ser 
         515                520                525
Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
     530                535                540
Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
 545                550                555                560
Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Lys Ile Val Glu Leu 
                 565                570                575
Met Gly Arg Glu Leu Asn Trp Ser Glu Leu Arg Lys Gln Glu Glu Leu 
             580                585                590
Glu Thr Ala Thr Arg Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
         595                600                605
Thr Glu Gln Leu Thr Asp Ser Thr Glu Ile Ser Leu Leu Pro Pro Asp 
     610                615                620
Ile Asp Arg Tyr Lys Lys Arg Phe His Met Phe Asp Glu Asp Glu Lys 
 625                630                635                640
Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                 645                650                655
Val Gln Met Asp Glu Asp Thr Leu His Glu Ile Leu Cys Glu Val Asp 
             660                665                670
Leu Asn Lys Asn Gly Gln Val Glu Leu His Glu Phe Leu Gln Leu Met 
         675                680                685
Ser Ala Val His Thr Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
     690                695                700
Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
 705                710                715                720
Asp Arg Ser Cys Gly Gly Leu 
                 725



<210> 10070
<211> 2425
<212> DNA
<213> Homo sapiens
<308> AK022596
<400> 10070

tataattat  tgttaaata  ggcac  2425



<210> 10071
<211> 727
<212> PRT
<213> Homo sapiens
<308> AAB60403
<400> 10071

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
  1               5                  10                  15
Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
             20                  25                  30
Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
         35                  40                  45
Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
     50                  55                  60
Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
 65                  70                  75                  80
Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                 85                  90                  95
Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
             100                105                110
Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys 
         115                120                125
Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
     130                135                140
Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
 145                150                155                160
Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                 165                170                175
Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser 
             180                185                190
Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
         195                200                205
Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
     210                215                220
Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
 225                230                235                240
Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                 245                250                255
Asp Pro Gln Thr Gly Lys Val His Val Ser Gly Ala Arg Cys Lys Asp 
             260                265                270
Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
         275                280                285
Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp 
     290                295                300
Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
 305                310                315                320
Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser 
                 325                330                335
Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala 
             340                345                350
Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
         355                360                365
Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
     370                375                380
Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
 385                390                395                400
Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile 
                 405                410                415
Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile Thr Ile 
             420                425                430
Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Ile 
         435                440                445
Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser Arg Thr 
     450                455                460
Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
 465                470                475                480
Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                 485                490                495
Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala 
             500                505                510
Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val His Leu Val Ser 
         515                520                525
Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
     530                535                540
Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
 545                550                555                560
Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu 
                 565                570                575
Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu Gln Leu 
             580                585                590
Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
         595                600                605
Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro Ser Asp 
     610                615                620
Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp Gln Lys 
 625                630                635                640
Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                 645                650                655
Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp 
             660                665                670
Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met 
         675                680                685
Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
     690                695                700
Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
 705                710                715                720
Asp Arg Ser Cys Gly Gly Leu 
                 725



<210> 10073
<211> 727
<212> PRT
<213> Rattus norvegicus
<308> P35571
<400> 10073

Met Ala Phe Gln Lys Val Val Lys Gly Thr Ile Leu Met Gly Gly Gly 
  1               5                  10                  15
Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
             20                  25                  30
Lys Gln Val Ser Leu Ala Tyr Val Glu Ala Ala Thr Cys Phe Ser Glu 
         35                  40                  45
Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Met Thr Leu 
     50                  55                  60
Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
 65                  70                  75                  80
Gly Cys Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                 85                  90                  95
Leu Val Glu Arg Asn Asp Phe Ala Ser Gly Thr Ser Ser Arg Ser Thr 
             100                105                110
Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Thr Asn 
         115                120                125
Leu Asp Val Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
     130                135                140
Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
 145                150                155                160
Met Leu Pro Leu Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                 165                170                175
Ile Lys Met Tyr Asp Leu Val Ala Gly Ser His Cys Leu Lys Ser Ser 
             180                185                190
Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
         195                200                205
Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
     210                215                220
Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
 225                230                235                240
Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                 245                250                255
Asp Pro Glu Thr Gly Lys Glu Arg Val Ser Gly Ala Arg Cys Lys Asp 
             260                265                270
Val Leu Thr Gly His Glu Phe Asn Val Arg Ala Lys Cys Val Ile Asn 
         275                280                285
Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Asn Asp 
     290                295                300
Val Val Pro Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
 305                310                315                320
Gly Tyr Tyr Ser Pro Glu Asn Met Gly Leu Leu Asp Pro Ala Thr Ser 
                 325                330                335
Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Glu Lys Met Thr Ile Ala 
             340                345                350
Gly Thr Thr Asp Ser Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
         355                360                365
Glu Asp Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
     370                375                380
Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
 385                390                395                400
Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asn Thr Gln Ser Ile 
                 405                410                415
Ser Arg Asn His Val Val Glu Val Ser Asp Ser Gly Leu Ile Thr Ile 
             420                425                430
Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Val 
         435                440                445
Asn Lys Ala Val Lys Leu His Asn Leu Asn Ala Gly Pro Ser Arg Thr 
     450                455                460
Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
 465                470                475                480
Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                 485                490                495
Leu Ala Lys Thr Tyr Gly Asp Lys Ala Phe Asp Val Ala Lys Met Ala 
             500                505                510
Ser Val Thr Gly Lys Arg Trp Pro Val Val Gly Val Arg Leu Val Ser 
         515                520                525
Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
     530                535                540
Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
 545                550                555                560
Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Lys Ile Val Glu Leu 
                 565                570                575
Met Gly Arg Glu Leu Asn Trp Ser Glu Leu Arg Lys Gln Glu Glu Leu 
             580                585                590
Glu Thr Ala Thr Arg Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
         595                600                605
Thr Glu Gln Leu Thr Asp Ser Thr Glu Ile Ser Leu Leu Pro Pro Asp 
     610                615                620
Ile Asp Arg Tyr Lys Lys Arg Phe His Met Phe Asp Glu Asp Glu Lys 
 625                630                635                640
Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                 645                650                655
Val Gln Met Asp Glu Asp Thr Leu His Glu Ile Leu Cys Glu Val Asp 
             660                665                670
Leu Asn Lys Asn Gly Gln Val Glu Leu His Glu Phe Leu Gln Leu Met 
         675                680                685
Ser Ala Val His Thr Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
     690                695                700
Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
 705                710                715                720
Asp Arg Ser Cys Gly Gly Leu 
                 725



<210> 10074
<211> 2425
<212> DNA
<213> Homo sapiens
<308> AK022596
<400> 10074

tataattat  tgttaaata  ggcac  2425



<210> 10075
<211> 727
<212> PRT
<213> Homo sapiens
<308> AAB60403
<400> 10075

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
  1               5                  10                  15
Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
             20                  25                  30
Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
         35                  40                  45
Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
     50                  55                  60
Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
 65                  70                  75                  80
Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                 85                  90                  95
Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
             100                105                110
Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys 
         115                120                125
Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
     130                135                140
Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
 145                150                155                160
Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                 165                170                175
Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser 
             180                185                190
Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
         195                200                205
Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
     210                215                220
Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
 225                230                235                240
Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                 245                250                255
Asp Pro Gln Thr Gly Lys Val His Val Ser Gly Ala Arg Cys Lys Asp 
             260                265                270
Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
         275                280                285
Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp 
     290                295                300
Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
 305                310                315                320
Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser 
                 325                330                335
Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala 
             340                345                350
Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
         355                360                365
Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
     370                375                380
Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
 385                390                395                400
Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile 
                 405                410                415
Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile Thr Ile 
             420                425                430
Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Ile 
         435                440                445
Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser Arg Thr 
     450                455                460
Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
 465                470                475                480
Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                 485                490                495
Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala 
             500                505                510
Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val His Leu Val Ser 
         515                520                525
Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
     530                535                540
Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
 545                550                555                560
Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu 
                 565                570                575
Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu Gln Leu 
             580                585                590
Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
         595                600                605
Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro Ser Asp 
     610                615                620
Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp Gln Lys 
 625                630                635                640
Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                 645                650                655
Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp 
             660                665                670
Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met 
         675                680                685
Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
     690                695                700
Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
 705                710                715                720
Asp Arg Ser Cys Gly Gly Leu 
                 725



<210> 10076
<211> 943
<212> DNA
<213> Rattus norvegicus
<308> X78603
<400> 10076

actccgccc  tgctgggtc  gtcgatcct  gttccgtca  ggaccgtga  ggggtcaac  60
tgaggtcgg  ggggttagt  acgcggtgg  ggcggctcc  cctccaaaa  ttgagcagg  120
acagggtgc  aaacaggat  tacacgctg  tttccgggc  gtacaagta  atgttccag  180
aggatgaat  ctgcatcct  atcctgggc  tggacaatg  tgggaagac  accttcctg  240
aacagtcaa  aacacgatt  aacaagaac  acaagggaa  gagtctatc  aaaatcacc  300
ctaccgtgg  tctaaacat  ggcactgtg  acgtaggaa  ggctcgtct  atgttttgg  360
acttaggtg  gcaggaaga  ctgcagtcg  tgtgggaca  gtactatgc  gagtgccat  420
gtgtcatct  tgtcattga  tccactgat  aggagaggc  gtcagaatc  aaagaggca  480
ttgagaagg  ggtttcgag  gaagcactg  acggtgttc  catcctggt  ttggccaac  540
agcaggatg  ggagacttg  ctctccatt  ctgacatca  gactgcatt  agtgactgt  600
cctgcaaga  tggcaggcg  gattgtttg  cccaggcct  ctctgccct  acaggcaag  660
gagttcgag  gggcatcga  tggatggtg  agtgtgtcg  acggaatgt  caccggcca  720
cacggcaga  ggacatcac  taagcacct  catcctcac  gtcttggac  gttcatccc  780
tagtgttgg  agagtattc  ctgctggct  ctgtcctcc  gatgctggg  gttgagctg  840
gtttgtctg  tcattttta  ttgctttat  ttttctcta  gacaaactt  tctctgtgt  900
tggaaaagt  taggtattc  gagacaaaa  aaaaaaaaa  aaa  943



<210> 10077
<211> 201
<212> PRT
<213> Rattus norvegicus
<308> Q63055
<400> 10077

Met Tyr Thr Leu Leu Ser Gly Leu Tyr Lys Tyr Met Phe Gln Lys Asp 
  1               5                  10                  15
Glu Tyr Cys Ile Leu Ile Leu Gly Leu Asp Asn Ala Gly Lys Thr Thr 
             20                  25                  30
Phe Leu Glu Gln Ser Lys Thr Arg Phe Asn Lys Asn Tyr Lys Gly Met 
         35                  40                  45
Ser Leu Ser Lys Ile Thr Thr Thr Val Gly Leu Asn Ile Gly Thr Val 
     50                  55                  60
Asp Val Gly Lys Ala Arg Leu Met Phe Trp Asp Leu Gly Gly Gln Glu 
 65                  70                  75                  80
Glu Leu Gln Ser Leu Trp Asp Lys Tyr Tyr Ala Glu Cys His Gly Val 
                 85                  90                  95
Ile Tyr Val Ile Asp Ser Thr Asp Glu Glu Arg Leu Ser Glu Ser Lys 
             100                105                110
Glu Ala Phe Glu Lys Val Val Ser Ser Glu Ala Leu Asp Gly Val Pro 
         115                120                125
Ile Leu Val Leu Ala Asn Lys Gln Asp Val Glu Thr Cys Leu Ser Ile 
     130                135                140
Pro Asp Ile Lys Thr Ala Phe Ser Asp Cys Thr Cys Lys Ile Gly Arg 
 145                150                155                160
Arg Asp Cys Leu Thr Gln Ala Cys Ser Ala Leu Thr Gly Lys Gly Val 
                 165                170                175
Arg Glu Gly Ile Glu Trp Met Val Lys Cys Val Val Arg Asn Val His 
             180                185                190
Arg Pro Pro Arg Gln Arg Asp Ile Thr 
         195                200



<210> 10078
<211> 1559
<212> DNA
<213> Homo sapiens
<308> X91504
<400> 10078

cgcagggca  gatgtacac  ctgctgtcg  gcttgtaca  gtacatgtt  cagaaggac  60
agtactgca  cctgatcct  ggcctggac  atgctggga  gacgacctt  ctggagcag  120
cgaaaaccc  atttaacaa  aactacaag  ggatgagtc  atccaaaat  accaccacc  180
tgggcctaa  catcggcac  gtggatgtg  gaaaggctc  gctcatgtt  tgggactta  240
gagggcagg  agagctgca  tctttgtgg  acaagtatt  tgcggagtg  cacggcgtc  300
tctacgtca  tgactccac  gacgaggag  ggctggctg  gtccaagca  gcgtttgag  360
aggtggtga  cagcgaggc  ctgtgcggt  tccccgtct  ggtgctggc  aacaagcag  420
atgtggaga  gtgcctctc  atccctgac  tcaagacgg  cttcagcga  tgcaccagc  480
agatcggca  gcgcgattg  ctgacccag  cctgctcgg  cctcacagg  aaaggggtg  540
gcgagggca  cgagtggat  gtgaagtgt  tcgtgcgga  tgtgcaccg  ccgccgcgg  600
agagggaca  cacgtagcg  cagccgcgc  gccgtcggg  cggctggtc  cctggtgct  660
gaggagtgg  ctcctgttg  ctcccatgc  gctgatctg  ggggtgggt  tgctttgct  720
tggggttct  ctatttact  tgttttctc  aagacaaac  ttcctctat  tctggaaaa  780
cgtaggcat  cggaggctt  ggaggggag  ctggcagcc  ggctggccc  ggccctgca  840
cggcagcct  tccacaggg  gcagcggcg  cctttcgag  ccctttctg  ggggtctga  900
ggagacctg  ttgggaatt  gggctccag  gctcaggct  gcttgggct  catgaggac  960
gccctgtgg  accctcggg  gaccccgtg  ctgtctccg  cccatcgag  aggaggccc  1020
tcagccatg  ctgccatct  gcttctgcc  tgtgacccc  tgaccccgg  agtggtctg  1080
ggctgatct  gccttgagg  agacccagg  catgttccc  aaggccagc  ggggccctg  1140
attgtgatg  agcctcggg  cagggctga  gcctgcggg  gaagaccta  accccacgc  1200
tgggcctgg  ttcacctca  cctaatccc  cgggaggga  ctgactgat  caaaaagct  1260
agggggcct  ctgggagtg  ctgttttta  gccccagcc  cgcaagttg  ggagtgttt  1320
tgggggtcc  gagccctcc  ccagccagg  gagaacctc  cggaggggt  ctctgtggg  1380
ccctgtgtc  cctgctcgg  agtaaggct  gtcctgggg  cctccctgc  cggacccca  1440
tgggcctgc  gagtgctgt  ttcttcctc  gtctggctg  gggcaggag  ggcctgccc  1500
gtgtcaccc  gggtgagtg  aaaataaag  cggcgagtg  gaaaaaaaa  aaaaaaaaa  1559



<210> 10079
<211> 201
<212> PRT
<213> Homo sapiens
<308> Q13795
<400> 10079

Met Tyr Thr Leu Leu Ser Gly Leu Tyr Lys Tyr Met Phe Gln Lys Asp 
  1               5                  10                  15
Glu Tyr Cys Ile Leu Ile Leu Gly Leu Asp Asn Ala Gly Lys Thr Thr 
             20                  25                  30
Phe Leu Glu Gln Ser Lys Thr Arg Phe Asn Lys Asn Tyr Lys Gly Met 
         35                  40                  45
Ser Leu Ser Lys Ile Thr Thr Thr Val Gly Leu Asn Ile Gly Thr Val 
     50                  55                  60
Asp Val Gly Lys Ala Arg Leu Met Phe Trp Asp Leu Gly Gly Gln Glu 
 65                  70                  75                  80
Glu Leu Gln Ser Leu Trp Asp Lys Tyr Tyr Ala Glu Cys His Gly Val 
                 85                  90                  95
Ile Tyr Val Ile Asp Ser Thr Asp Glu Glu Arg Leu Ala Glu Ser Lys 
             100                105                110
Gln Ala Phe Glu Lys Val Val Thr Ser Glu Ala Leu Cys Gly Val Pro 
         115                120                125
Val Leu Val Leu Ala Asn Lys Gln Asp Val Glu Thr Cys Leu Ser Ile 
     130                135                140
Pro Asp Ile Lys Thr Ala Phe Ser Asp Cys Thr Ser Lys Ile Gly Arg 
 145                150                155                160
Arg Asp Cys Leu Thr Gln Ala Cys Ser Ala Leu Thr Gly Lys Gly Val 
                 165                170                175
Arg Glu Gly Ile Glu Trp Met Val Lys Cys Val Val Arg Asn Val His 
             180                185                190
Arg Pro Pro Arg Gln Arg Asp Ile Thr 
         195                200



<210> 10080
<211> 1483
<212> DNA
<213> Rattus norvegicus
<308> X78606
<400> 10080

ccagcatcc  cggacacca  gtcagactc  gaggaggag  gccaggacc  gcaactgaa  60
atcgtcgtg  tgggggacg  cacctccgg  aagacttcc  tagctacgt  ttttgctca  120
gagacattt  ggaaacagt  caagcagac  ataggactg  atttctttt  gagaaggat  180
accttacca  gaaatttga  tgttactct  caagtttgg  atataggag  gcagacaat  240
ggtggcaag  tgttggata  atacatcta  ggagcacag  gaatcctct  ggtatatga  300
attacaaac  accaaagct  tgagaattt  gaagattgg  attctgtgg  gaagacagt  360
agcgaagag  cagaaactc  gcccctggt  gctttagta  gcaataaaa  tgacttgga  420
catatgcga  cagtaaaac  tgataaaca  ttacgattt  gccaggaaa  tggttttag  480
agccacttt  tttcagcca  gacgggaga  tctgtcttc  tgtgttttc  gaaagttgc  540
gcagaaatc  tgggaatca  gttaaacaa  gcagaaata  aacagtcac  gagagtggt  600
aaggcagat  ttgtaaact  caaccagga  cccatgtca  gaactgtta  tccacctcg  660
agctccatg  gtgcagttc  gtgagcaca  actgtattg  tagttctgg  tgctcttcc  720
tggattggg  ccaagctgc  taggaacat  ttttatcag  gactgtctc  gtagtcagc  780
cacacttcc  cctgctctg  tccttcatc  cttagtcgc  tcagagtat  gggcagctc  840
ctggacagg  aggaattca  atttggaac  acatgtttt  aaatctgaa  ggaaagtcc  900
ttctctgga  tgagactgc  tcctcgctc  agaagaacc  tgttgcttc  ttatctctt  960
ttttttccc  gatttaaaa  atttaaaca  atatgaaga  gctccacgc  ttgatcatc  1020
ttttctatt  gaacttgta  atgtgaacg  gtacttgag  gcactgatg  tggaagtta  1080
caagaaggt  ttcctttgc  ggctattaa  agtaaacta  acaaagctg  atctgattg  1140
aagtgcttc  aatgaggct  caatagaaa  attttttca  ttttaaaag  agcctaatg  1200
gtttatatt  tagtttata  ctcacaagt  ctgagtatt  gatattgta  ttttattac  1260
gtatcatgg  cattgcata  tttatcata  ttggcttag  tggctttat  aattttgat  1320
aatggttca  ctgatcctc  acatggaat  tctcctaca  gctgtatga  agtgcttcc  1380
gatgagtca  gatatcctt  gatcattgt  gatcgatca  actgtacct  atgttctga  1440
gtttttctc  cataaataa  tttatttaa  ttaaaaaaa  aaa  1483



<210> 10081
<211> 221
<212> PRT
<213> Rattus norvegicus
<308> P51158
<400> 10081

Met Ser Asp Ser Glu Glu Glu Ser Gln Asp Arg Gln Leu Lys Ile Val 
  1               5                  10                  15
Val Leu Gly Asp Gly Thr Ser Gly Lys Thr Ser Leu Ala Thr Cys Phe 
             20                  25                  30
Ala Gln Glu Thr Phe Gly Lys Gln Tyr Lys Gln Thr Ile Gly Leu Asp 
         35                  40                  45
Phe Phe Leu Arg Arg Ile Thr Leu Pro Gly Asn Leu Asn Val Thr Leu 
     50                  55                  60
Gln Val Trp Asp Ile Gly Gly Gln Thr Ile Gly Gly Lys Met Leu Asp 
 65                  70                  75                  80
Lys Tyr Ile Tyr Gly Ala Gln Gly Ile Leu Leu Val Tyr Asp Ile Thr 
                 85                  90                  95
Asn Tyr Gln Ser Phe Glu Asn Leu Glu Asp Trp Tyr Ser Val Val Lys 
             100                105                110
Thr Val Ser Glu Glu Ser Glu Thr Gln Pro Leu Val Ala Leu Val Gly 
         115                120                125
Asn Lys Ile Asp Leu Glu His Met Arg Thr Val Lys Pro Asp Lys His 
     130                135                140
Leu Arg Phe Cys Gln Glu Asn Gly Phe Ser Ser His Phe Val Ser Ala 
 145                150                155                160
Lys Thr Gly Asp Ser Val Phe Leu Cys Phe Gln Lys Val Ala Ala Glu 
                 165                170                175
Ile Leu Gly Ile Lys Leu Asn Lys Ala Glu Ile Glu Gln Ser Gln Arg 
             180                185                190
Val Val Lys Ala Asp Ile Val Asn Tyr Asn Gln Glu Pro Met Ser Arg 
         195                200                205
Thr Val Asn Pro Pro Arg Ser Ser Met Cys Ala Val Gln 
     210                215                220



<210> 10082
<211> 1597
<212> DNA
<213> Homo sapiens
<308> BC018067
<400> 10082

ggggaggtg  gcaagatgg  gcttgccga  tgattctcc  cgaatacct  ctgccggcg  60
ggagacacc  gggcggggg  cctgccgca  ctacctccc  tcctcctct  ccccgcccc  120
ggagccttc  tccttccct  cccccccca  ctcgagggg  gggcctggt  cccgggaca  180
catgtcgga  tctgaggag  agagccagg  ccggcaact  aaaatcgtc  tgctggggg  240
cggcgcctc  gggaagacc  ccttaacta  gtgttttgc  caagaaact  ttgggaaac  300
gtacaaaca  actatagga  tggatttct  tttgagaag  ataacattg  caggaaact  360
gaatgttac  cttcaaatt  gggatatag  agggcagac  ataggaggc  aaatgttgg  420
taaatatat  tatggagca  agttgattt  gagcatatg  gaacaataa  acctgaaaa  480
cacttacgg  tttgccagg  aaatggttt  agtagccac  ttgtctcag  caagacagg  540
gactctgtc  tcctgtgct  tcagaaagt  gctgctgaa  tccttggga  caaattaaa  600
aaagcagaa  tagaacagt  acagagggt  gtgaaggca  atattgtaa  ctacaacca  660
gaacctatg  caaggactg  taaccctcc  agaagctct  tgtgtgcag  tcagtgagc  720
catttttct  ttgtgttga  agttctggc  gcccttcac  tctgggtgg  cccgaggac  780
tctaggaac  tgttttatc  gtgaccatc  ctgtagttc  gttaacact  tactcccaa  840
ttgcttcat  attgctatt  cctcacagt  gcaggcagc  ccttggatt  gaaagaatt  900
aactttggg  ccacacact  tgaattcaa  atggaaaac  cattccctg  aattagact  960
cttcattgc  aaagaatga  gttgtttct  tgtatgtcc  tgcttcttt  ttcattgat  1020
taaattttt  taacttaat  tgaaaactc  ccaagtctt  atcatcatc  aggattttg  1080
cacagcaat  tcattctct  atcggaact  gtatgtgtc  aagtatact  cagagtgca  1140
acattaagc  agtaatata  tttacctac  gatacttat  aagacattc  ttcgctatc  1200
tgagtaaaa  tatataaag  tgtttctaa  tgaaaatgc  tgaaataag  ctgtaatag  1260
aatattttt  catttttta  aaaagggcc  aaattgttt  tattgtagt  tgtaactca  1320
aaagtaata  ttgatattg  atttttatt  ctgtatcgt  gtcgttatg  attgtgtaa  1380
actcaggtt  gaaggcttt  tgaattctg  taaatgttc  gctgatgct  cacgtggaa  1440
ttctcttgc  aactgcata  gagtactcc  gagaatgag  tatgacatt  tggatcaga  1500
tgtacctga  gttcagatg  ttttctttc  caaataaac  tatttaaat  aaaaaaaaa  1560
aaaaaaaaa  aaaaaaaaa  gaaaaaaaa  aaaaaaa  1597



<210> 10083
<211> 221
<212> PRT
<213> Homo sapiens
<308> P51157
<400> 10083

Met Ser Asp Ser Glu Glu Glu Ser Gln Asp Arg Gln Leu Lys Ile Val 
  1               5                  10                  15
Val Leu Gly Asp Gly Thr Ser Gly Lys Thr Ser Leu Thr Thr Cys Phe 
             20                  25                  30
Ala Gln Glu Thr Phe Gly Lys Gln Tyr Lys Gln Thr Ile Gly Leu Asp 
         35                  40                  45
Phe Phe Leu Arg Arg Ile Thr Leu Pro Gly Asn Leu Asn Val Thr Leu 
     50                  55                  60
Gln Ile Trp Asp Ile Gly Gly Gln Thr Ile Gly Gly Lys Met Leu Asp 
 65                  70                  75                  80
Lys Tyr Ile Tyr Gly Ala Gln Gly Val Leu Leu Val Tyr Asp Ile Thr 
                 85                  90                  95
Asn Tyr Gln Ser Phe Glu Asn Leu Glu Asp Trp Tyr Thr Val Val Lys 
             100                105                110
Lys Val Ser Glu Glu Ser Glu Thr Gln Pro Leu Val Ala Leu Val Gly 
         115                120                125
Asn Lys Ile Asp Leu Glu His Met Arg Thr Ile Lys Pro Glu Lys His 
     130                135                140
Leu Arg Phe Cys Gln Glu Asn Gly Phe Ser Ser His Phe Val Ser Ala 
 145                150                155                160
Lys Thr Gly Asp Ser Val Phe Leu Cys Phe Gln Lys Val Ala Ala Glu 
                 165                170                175
Ile Leu Gly Ile Lys Leu Asn Lys Ala Glu Ile Glu Gln Ser Gln Arg 
             180                185                190
Val Val Lys Ala Asp Ile Val Asn Tyr Asn Gln Glu Pro Met Ser Arg 
         195                200                205
Thr Val Asn Pro Pro Arg Ser Ser Met Cys Ala Val Gln 
     210                215                220



<210> 10084
<211> 1838
<212> DNA
<213> Rattus norvegicus
<308> X78949
<400> 10084

gaattccgc  ggattccgc  ttcctcacg  cccgctatc  aggtgtgtg  acctgtggg  60
tgctccaag  tgatctggg  tgtattaat  atggggatt  tacttcctc  gtgttcagc  120
catccaggc  tttttactt  aattggtca  atgactgac  tgatccata  tgagaaaga  180
ctggtgacg  cactaaaag  ttacattaa  gcagaagag  acaagttag  gcaaatcaa  240
aaatgggca  agaagttag  ccggctaac  agtacagca  caaaagatc  agaagggtt  300
gtcggacac  ctgtaaatg  attcaagtt  atgaaacgt  tgaacaccg  gtggagtga  360
ttggagaat  tgatcctca  ggatatgtc  gatggcttc  tctctaacc  gaccattca  420
aggcagtac  tccctaacg  cgaagacca  gttggggct  caaaagctt  gtttcgtct  480
caagacacc  acaacctag  cacgaatac  atctcgaag  gcaatcttc  aggagtgaa  540
cacaagtct  ttctaacag  tgaggactg  tttgagttg  gcaaagtgg  ctatacaga  600
gcagattat  accacacag  actctggat  gagcaggct  tgatgcagc  ggaggaggg  660
gagatgtct  ctgtagaca  agtctcggt  ctagattat  tgagctatg  agtgtacca  720
cagggtgac  tggataagg  acttctgct  acaaagaaa  ttcttgaac  agatcctga  780
caccagaga  ccaatggta  cttagtata  tttgagtat  taatgagta  agaaaaaga  840
gccaataag  ctgcttcgg  tgagcgggc  gatcagaaa  ctacaccaa  gaaaaaggg  900
attgctgtg  actacctgc  agagagaca  aagtacgaa  tgctgtgcc  tggggaggg  960
atcaaaatg  ctcctcgga  acaaaaaag  ctgttctgc  gctaccatg  tggaaaccg  1020
aatcctaaa  ttatcctgg  cccagccaa  caggaggat  agtgggaca  gcctcgcat  1080
attcgtttc  atgacatca  ctcagatgc  gagattgag  tcgtcaaag  tttagcaaa  1140
cccaggctg  gccgagcta  agtacatga  cctgagact  ggaaattga  cacagcaca  1200
tacagagta  ctaagagtg  ttggctgtc  ggctatgaa  atcctgtgg  gtctcgaat  1260
aatatgaga  tacaagatc  cacaggact  gatgtttcc  cggcagagg  attacaggt  1320
gcaaattat  gagttggag  acagtatga  ccccatttt  actttgcca  gaaagacga  1380
ccggatgct  ttagagagc  tgggacagg  aataggatt  ccacgtggc  cttctacat  1440
agtgatgtg  ctgctggag  cgctactgt  tttcctgaa  tgggagcca  tgtttggcc  1500
aaaaaaggc  ctgctgtct  ctggtacaa  ctgtttgcc  gtggagaag  agattacag  1560
acacggcac  cagcctgtc  tgtgctagt  ggaaacaaa  gggtatcca  caaatggct  1620
catgaacgt  gacaggaat  tcgaaggcc  tgtaccctg  cagaattgg  atgacaacc  1680
ggcttcccg  ggctcctct  gtcctctaa  gcaccaggc  tgatcgctg  ctgtaacat  1740
cagaagttt  cagctgact  acactccat  attaattcg  ccgtgaacc  catcccatg  1800
ttcatctgt  gacaatcac  tatttttgt  aatttttt  1838



<210> 10085
<211> 534
<212> PRT
<213> Rattus norvegicus
<308> P54001
<400> 10085

Met Ile Trp Gly Val Leu Met Met Gly Ile Leu Leu Pro Gln Cys Ser 
  1               5                  10                  15
Ala His Pro Gly Phe Phe Thr Ser Ile Gly Gln Met Thr Asp Leu Ile 
             20                  25                  30
His Asn Glu Lys Asp Leu Val Thr Ser Leu Lys Asp Tyr Ile Lys Ala 
         35                  40                  45
Glu Glu Asp Lys Leu Glu Gln Ile Lys Lys Trp Ala Glu Lys Leu Asp 
     50                  55                  60
Arg Leu Thr Ser Thr Ala Thr Lys Asp Pro Glu Gly Phe Val Gly His 
 65                  70                  75                  80
Pro Val Asn Ala Phe Lys Leu Met Lys Arg Leu Asn Thr Glu Trp Ser 
                 85                  90                  95
Glu Leu Glu Asn Leu Ile Leu Lys Asp Met Ser Asp Gly Phe Ile Ser 
             100                105                110
Asn Leu Thr Ile Gln Arg Gln Tyr Phe Pro Asn Asp Glu Asp Gln Val 
         115                120                125
Gly Ala Ala Lys Ala Leu Phe Arg Leu Gln Asp Thr Tyr Asn Leu Asp 
     130                135                140
Thr Asn Thr Ile Ser Lys Gly Asn Leu Pro Gly Val Lys His Lys Ser 
 145                150                155                160
Phe Leu Thr Ala Glu Asp Cys Phe Glu Leu Gly Lys Val Ala Tyr Thr 
                 165                170                175
Glu Ala Asp Tyr Tyr His Thr Glu Leu Trp Met Glu Gln Ala Leu Met 
             180                185                190
Gln Leu Glu Glu Gly Glu Met Ser Thr Val Asp Lys Val Ser Val Leu 
         195                200                205
Asp Tyr Leu Ser Tyr Ala Val Tyr Gln Gln Gly Asp Leu Asp Lys Ala 
     210                215                220
Leu Leu Leu Thr Lys Lys Leu Leu Glu Leu Asp Pro Glu His Gln Arg 
 225                230                235                240
Ala Asn Gly Asn Leu Val Tyr Phe Glu Tyr Ile Met Ser Lys Glu Lys 
                 245                250                255
Asp Ala Asn Lys Ser Ala Ser Gly Glu Arg Ala Asp Gln Lys Thr Thr 
             260                265                270
Pro Lys Lys Lys Gly Ile Ala Val Asp Tyr Leu Pro Glu Arg Gln Lys 
         275                280                285
Tyr Glu Met Leu Cys Arg Gly Glu Gly Ile Lys Met Thr Pro Arg Arg 
     290                295                300
Gln Lys Arg Leu Phe Cys Arg Tyr His Asp Gly Asn Arg Asn Pro Lys 
 305                310                315                320
Phe Ile Leu Ala Pro Ala Lys Gln Glu Asp Glu Trp Asp Lys Pro Arg 
                 325                330                335
Ile Ile Arg Phe His Asp Ile Ile Ser Asp Ala Glu Ile Glu Ile Val 
             340                345                350
Lys Asp Leu Ala Lys Pro Arg Leu Ser Arg Ala Thr Val His Asp Pro 
         355                360                365
Glu Thr Gly Lys Leu Thr Thr Ala Gln Tyr Arg Val Ser Lys Ser Ala 
     370                375                380
Trp Leu Ser Gly Tyr Glu Asp Pro Val Val Ser Arg Ile Asn Met Arg 
 385                390                395                400
Ile Gln Asp Leu Thr Gly Leu Asp Val Ser Thr Ala Glu Glu Leu Gln 
                 405                410                415
Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp Phe 
             420                425                430
Ala Arg Lys Asp Glu Pro Asp Ala Phe Arg Glu Leu Gly Thr Gly Asn 
         435                440                445
Arg Ile Ala Thr Trp Leu Phe Tyr Met Ser Asp Val Ser Ala Gly Gly 
     450                455                460
Ala Thr Val Phe Pro Glu Val Gly Ala Ser Val Trp Pro Lys Lys Gly 
 465                470                475                480
Thr Ala Val Phe Trp Tyr Asn Leu Phe Ala Ser Gly Glu Gly Asp Tyr 
                 485                490                495
Ser Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Asn Lys Trp Val 
             500                505                510
Ser Asn Lys Trp Leu His Glu Arg Gly Gln Glu Phe Arg Arg Pro Cys 
         515                520                525
Thr Leu Ser Glu Leu Glu 
     530



<210> 10086
<211> 2722
<212> DNA
<213> Homo sapiens
<308> M24487
<400> 10086

gagcgggct  agggtagga  gtagccgct  cgagtggag  cgactgggg  ctgaagagc  60
cgccgccct  tcgtcccac  ttccaggtg  gtgatcctg  aaaattaaa  cttccaaga  120
gatctggta  atattaatt  taggaattc  gcttcccca  tctttggct  atccaggct  180
ttttacttc  attggtcag  tgactgatt  gatccatac  gagaaagat  tggtgactt  240
tctgaaaga  tatattaag  cagaagagg  caagttaga  caaataaaa  aatgggcag  300
gaagttaga  cggctaact  gtacagcga  aaaagatcc  gaaggattt  ttgggcatc  360
agtaaatgc  ttcaaatta  tgaaacgtc  gaatactga  tggagtgag  tggagaatc  420
ggtccttaa  gatatgtca  atggcttta  ctctaacct  accattcag  gaccagtac  480
ttctaatga  gaagatcag  ttggggcag  caaagctct  ttacgtctc  aggatacct  540
caatttgga  acagatacc  tctcaaagg  taatcttcc  ggagtgaaa  acaaatctt  600
tctaacggc  gaggactgc  ttgagttgg  caaagtggc  tatacagaa  cagattatt  660
ccatacgga  ctgtggatg  aacaagccc  aaggcaact  gatgaaggc  agatttcta  720
catagataa  gtctctgtt  tagattatt  gagctatgc  gtatatcag  agggagacc  780
ggataaggc  cttttgctc  caaagaagc  tcttgaact  gatcctgaa  atcagagag  840
taatggtaa  ttaaaatat  ttgagtata  aatggctaa  gaaaaagat  tcaataagt  900
tgcttcaga  gaccaatct  atcagaaaa  tacaccaaa  aaaaaaggg  ttgctgtgg  960
ttacctgcc  gagagacag  agtacgaaa  gctgtgccg  ggggagggt  tcaaaatga  1020
ccctcggag  cagaaaaaa  tcttttgcc  ctaccatga  ggaaaccgt  atcctaaat  1080
tattctggc  ccagctaaa  aggaggatg  atgggacaa  cctcgtatt  ttcgcttcc  1140
tgatattat  tctgatgca  aaattgaaa  cgtcaaaga  ctagcaaaa  caaggctga  1200
gcgagccac  atttcaaac  caataacag  agacttgga  acggtacat  acagaattt  1260
taaaagtgc  tggctctct  gctatgaaa  tcctgtggt  tctcgaatt  atatgagaa  1320
acaagatct  acaggacta  atgtttcca  agcagagga  ttacaggta  caaattatg  1380
agttggagg  cagtatgaa  cccattttg  ctttgcacg  aaagatgag  cagatgctt  1440
caaagagct  gggacagga  atagaattg  tacatggct  ttttatatg  gtgatgtgt  1500
tgcaggagg  gccactgtt  ttcctgaag  tggagctag  gtttggccc  aaaaaggaa  1560
tgctgtttt  tggtataat  tgtttgcca  tggagaagg  gattatagt  cacggcatg  1620
agcctgtcc  gtgctagtt  gcaacaaat  ggtatccaa  aaatggctc  atgaacgtg  1680
acaagaatt  cgaagacct  gtacgttgt  agaattgga  tgacaaaca  gcttccctt  1740
ttctcctat  gttgtactc  tatgtgtct  atatacaca  ttccatagt  ttaactttc  1800
ggagtttac  attgactaa  actccatga  tgattcagt  atgaacctc  tcccatgtt  1860
catctgtgg  caattgctt  ctttgtggg  tcttttaaa  gtaacacga  atcatcata  1920
tgcataaaa  cttaaagtt  tgttggtat  acagaagac  aggcagagt  taaagtgag  1980
aattttata  ttaaagaac  ttttggttg  ataaaaaca  aatttgagc  tccagtttt  2040
gtatttcac  acatctcag  tggtgggtg  taagctaga  tgggctgtg  gataggaaa  2100
aaatgcctt  cagatgtgc  taggtgttc  gtttaccta  tgtcttact  tgttttctg  2160
atctgaaga  tagtaataa  ctaggacac  aactgggtt  catgtgatt  ccctttcat  2220
tgatcttct  agttgattt  tttcctccc  agtcttttt  aaagaaagt  tactgtatt  2280
taccaaccc  ctctctttt  ttttagctc  tctgtggtg  attaaacgt  cttgagtta  2340
aatatttcg  ttttttttt  ttttttaat  gaaagtcct  cataacaac  ctgggcctt  2400
ttaactaaa  tgctcacca  ttagcctgt  tttttatcc  ttttttaaa  tgacagatg  2460
ttttgttca  gaattttgc  gtttttctt  gtgctaata  cttgcctct  attcctgct  2520
cagcagggt  gtaatattg  cattctgat  aaatactgt  ccttaggag  ctggaagtt  2580
aaaaatgta  aagtccttt  agtgatgag  gaattgatt  tttttaaaa  tctttttct  2640
agaaagcca  aatgtttgt  tttttaaga  tctgaaatg  gttgtgaca  caatgacct  2700
tttatgatc  taaatcttt  tt  2722



<210> 10087
<211> 534
<212> PRT
<213> Homo sapiens
<308> P13674
<400> 10087

Met Ile Trp Tyr Ile Leu Ile Ile Gly Ile Leu Leu Pro Gln Ser Leu 
  1               5                  10                  15
Ala His Pro Gly Phe Phe Thr Ser Ile Gly Gln Met Thr Asp Leu Ile 
             20                  25                  30
His Thr Glu Lys Asp Leu Val Thr Ser Leu Lys Asp Tyr Ile Lys Ala 
         35                  40                  45
Glu Glu Asp Lys Leu Glu Gln Ile Lys Lys Trp Ala Glu Lys Leu Asp 
     50                  55                  60
Arg Leu Thr Ser Thr Ala Thr Lys Asp Pro Glu Gly Phe Val Gly His 
 65                  70                  75                  80
Pro Val Asn Ala Phe Lys Leu Met Lys Arg Leu Asn Thr Glu Trp Ser 
                 85                  90                  95
Glu Leu Glu Asn Leu Val Leu Lys Asp Met Ser Asp Gly Phe Ile Ser 
             100                105                110
Asn Leu Thr Ile Gln Arg Gln Tyr Phe Pro Asn Asp Glu Asp Gln Val 
         115                120                125
Gly Ala Ala Lys Ala Leu Leu Arg Leu Gln Asp Thr Tyr Asn Leu Asp 
     130                135                140
Thr Asp Thr Ile Ser Lys Gly Asn Leu Pro Gly Val Lys His Lys Ser 
 145                150                155                160
Phe Leu Thr Ala Glu Asp Cys Phe Glu Leu Gly Lys Val Ala Tyr Thr 
                 165                170                175
Glu Ala Asp Tyr Tyr His Thr Glu Leu Trp Met Glu Gln Ala Leu Arg 
             180                185                190
Gln Leu Asp Glu Gly Glu Ile Ser Thr Ile Asp Lys Val Ser Val Leu 
         195                200                205
Asp Tyr Leu Ser Tyr Ala Val Tyr Gln Gln Gly Asp Leu Asp Lys Ala 
     210                215                220
Leu Leu Leu Thr Lys Lys Leu Leu Glu Leu Asp Pro Glu His Gln Arg 
 225                230                235                240
Ala Asn Gly Asn Leu Lys Tyr Phe Glu Tyr Ile Met Ala Lys Glu Lys 
                 245                250                255
Asp Val Asn Lys Ser Ala Ser Asp Asp Gln Ser Asp Gln Lys Thr Thr 
             260                265                270
Pro Lys Lys Lys Gly Val Ala Val Asp Tyr Leu Pro Glu Arg Gln Lys 
         275                280                285
Tyr Glu Met Leu Cys Arg Gly Glu Gly Ile Lys Met Thr Pro Arg Arg 
     290                295                300
Gln Lys Lys Leu Phe Cys Arg Tyr His Asp Gly Asn Arg Asn Pro Lys 
 305                310                315                320
Phe Ile Leu Ala Pro Ala Lys Gln Glu Asp Glu Trp Asp Lys Pro Arg 
                 325                330                335
Ile Ile Arg Phe His Asp Ile Ile Ser Asp Ala Glu Ile Glu Ile Val 
             340                345                350
Lys Asp Leu Ala Lys Pro Arg Leu Arg Arg Ala Thr Ile Ser Asn Pro 
         355                360                365
Ile Thr Gly Asp Leu Glu Thr Val His Tyr Arg Ile Ser Lys Ser Ala 
     370                375                380
Trp Leu Ser Gly Tyr Glu Asn Pro Val Val Ser Arg Ile Asn Met Arg 
 385                390                395                400
Ile Gln Asp Leu Thr Gly Leu Asp Val Ser Thr Ala Glu Glu Leu Gln 
                 405                410                415
Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp Phe 
             420                425                430
Ala Arg Lys Asp Glu Pro Asp Ala Phe Lys Glu Leu Gly Thr Gly Asn 
         435                440                445
Arg Ile Ala Thr Trp Leu Phe Tyr Met Ser Asp Val Ser Ala Gly Gly 
     450                455                460
Ala Thr Val Phe Pro Glu Val Gly Ala Ser Val Trp Pro Lys Lys Gly 
 465                470                475                480
Thr Ala Val Phe Trp Tyr Asn Leu Phe Ala Ser Gly Glu Gly Asp Tyr 
                 485                490                495
Ser Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Asn Lys Trp Val 
             500                505                510
Ser Asn Lys Trp Leu His Glu Arg Gly Gln Glu Phe Arg Arg Pro Cys 
         515                520                525
Thr Leu Ser Glu Leu Glu 
     530



<210> 10088
<211> 1838
<212> DNA
<213> Rattus norvegicus
<308> X78949
<400> 10088

gaattccgc  ggattccgc  ttcctcacg  cccgctatc  aggtgtgtg  acctgtggg  60
tgctccaag  tgatctggg  tgtattaat  atggggatt  tacttcctc  gtgttcagc  120
catccaggc  tttttactt  aattggtca  atgactgac  tgatccata  tgagaaaga  180
ctggtgacg  cactaaaag  ttacattaa  gcagaagag  acaagttag  gcaaatcaa  240
aaatgggca  agaagttag  ccggctaac  agtacagca  caaaagatc  agaagggtt  300
gtcggacac  ctgtaaatg  attcaagtt  atgaaacgt  tgaacaccg  gtggagtga  360
ttggagaat  tgatcctca  ggatatgtc  gatggcttc  tctctaacc  gaccattca  420
aggcagtac  tccctaacg  cgaagacca  gttggggct  caaaagctt  gtttcgtct  480
caagacacc  acaacctag  cacgaatac  atctcgaag  gcaatcttc  aggagtgaa  540
cacaagtct  ttctaacag  tgaggactg  tttgagttg  gcaaagtgg  ctatacaga  600
gcagattat  accacacag  actctggat  gagcaggct  tgatgcagc  ggaggaggg  660
gagatgtct  ctgtagaca  agtctcggt  ctagattat  tgagctatg  agtgtacca  720
cagggtgac  tggataagg  acttctgct  acaaagaaa  ttcttgaac  agatcctga  780
caccagaga  ccaatggta  cttagtata  tttgagtat  taatgagta  agaaaaaga  840
gccaataag  ctgcttcgg  tgagcgggc  gatcagaaa  ctacaccaa  gaaaaaggg  900
attgctgtg  actacctgc  agagagaca  aagtacgaa  tgctgtgcc  tggggaggg  960
atcaaaatg  ctcctcgga  acaaaaaag  ctgttctgc  gctaccatg  tggaaaccg  1020
aatcctaaa  ttatcctgg  cccagccaa  caggaggat  agtgggaca  gcctcgcat  1080
attcgtttc  atgacatca  ctcagatgc  gagattgag  tcgtcaaag  tttagcaaa  1140
cccaggctg  gccgagcta  agtacatga  cctgagact  ggaaattga  cacagcaca  1200
tacagagta  ctaagagtg  ttggctgtc  ggctatgaa  atcctgtgg  gtctcgaat  1260
aatatgaga  tacaagatc  cacaggact  gatgtttcc  cggcagagg  attacaggt  1320
gcaaattat  gagttggag  acagtatga  ccccatttt  actttgcca  gaaagacga  1380
ccggatgct  ttagagagc  tgggacagg  aataggatt  ccacgtggc  cttctacat  1440
agtgatgtg  ctgctggag  cgctactgt  tttcctgaa  tgggagcca  tgtttggcc  1500
aaaaaaggc  ctgctgtct  ctggtacaa  ctgtttgcc  gtggagaag  agattacag  1560
acacggcac  cagcctgtc  tgtgctagt  ggaaacaaa  gggtatcca  caaatggct  1620
catgaacgt  gacaggaat  tcgaaggcc  tgtaccctg  cagaattgg  atgacaacc  1680
ggcttcccg  ggctcctct  gtcctctaa  gcaccaggc  tgatcgctg  ctgtaacat  1740
cagaagttt  cagctgact  acactccat  attaattcg  ccgtgaacc  catcccatg  1800
ttcatctgt  gacaatcac  tatttttgt  aatttttt  1838



<210> 10089
<211> 534
<212> PRT
<213> Rattus norvegicus
<308> P54001
<400> 10089

Met Ile Trp Gly Val Leu Met Met Gly Ile Leu Leu Pro Gln Cys Ser 
  1               5                  10                  15
Ala His Pro Gly Phe Phe Thr Ser Ile Gly Gln Met Thr Asp Leu Ile 
             20                  25                  30
His Asn Glu Lys Asp Leu Val Thr Ser Leu Lys Asp Tyr Ile Lys Ala 
         35                  40                  45
Glu Glu Asp Lys Leu Glu Gln Ile Lys Lys Trp Ala Glu Lys Leu Asp 
     50                  55                  60
Arg Leu Thr Ser Thr Ala Thr Lys Asp Pro Glu Gly Phe Val Gly His 
 65                  70                  75                  80
Pro Val Asn Ala Phe Lys Leu Met Lys Arg Leu Asn Thr Glu Trp Ser 
                 85                  90                  95
Glu Leu Glu Asn Leu Ile Leu Lys Asp Met Ser Asp Gly Phe Ile Ser 
             100                105                110
Asn Leu Thr Ile Gln Arg Gln Tyr Phe Pro Asn Asp Glu Asp Gln Val 
         115                120                125
Gly Ala Ala Lys Ala Leu Phe Arg Leu Gln Asp Thr Tyr Asn Leu Asp 
     130                135                140
Thr Asn Thr Ile Ser Lys Gly Asn Leu Pro Gly Val Lys His Lys Ser 
 145                150                155                160
Phe Leu Thr Ala Glu Asp Cys Phe Glu Leu Gly Lys Val Ala Tyr Thr 
                 165                170                175
Glu Ala Asp Tyr Tyr His Thr Glu Leu Trp Met Glu Gln Ala Leu Met 
             180                185                190
Gln Leu Glu Glu Gly Glu Met Ser Thr Val Asp Lys Val Ser Val Leu 
         195                200                205
Asp Tyr Leu Ser Tyr Ala Val Tyr Gln Gln Gly Asp Leu Asp Lys Ala 
     210                215                220
Leu Leu Leu Thr Lys Lys Leu Leu Glu Leu Asp Pro Glu His Gln Arg 
 225                230                235                240
Ala Asn Gly Asn Leu Val Tyr Phe Glu Tyr Ile Met Ser Lys Glu Lys 
                 245                250                255
Asp Ala Asn Lys Ser Ala Ser Gly Glu Arg Ala Asp Gln Lys Thr Thr 
             260                265                270
Pro Lys Lys Lys Gly Ile Ala Val Asp Tyr Leu Pro Glu Arg Gln Lys 
         275                280                285
Tyr Glu Met Leu Cys Arg Gly Glu Gly Ile Lys Met Thr Pro Arg Arg 
     290                295                300
Gln Lys Arg Leu Phe Cys Arg Tyr His Asp Gly Asn Arg Asn Pro Lys 
 305                310                315                320
Phe Ile Leu Ala Pro Ala Lys Gln Glu Asp Glu Trp Asp Lys Pro Arg 
                 325                330                335
Ile Ile Arg Phe His Asp Ile Ile Ser Asp Ala Glu Ile Glu Ile Val 
             340                345                350
Lys Asp Leu Ala Lys Pro Arg Leu Ser Arg Ala Thr Val His Asp Pro 
         355                360                365
Glu Thr Gly Lys Leu Thr Thr Ala Gln Tyr Arg Val Ser Lys Ser Ala 
     370                375                380
Trp Leu Ser Gly Tyr Glu Asp Pro Val Val Ser Arg Ile Asn Met Arg 
 385                390                395                400
Ile Gln Asp Leu Thr Gly Leu Asp Val Ser Thr Ala Glu Glu Leu Gln 
                 405                410                415
Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp Phe 
             420                425                430
Ala Arg Lys Asp Glu Pro Asp Ala Phe Arg Glu Leu Gly Thr Gly Asn 
         435                440                445
Arg Ile Ala Thr Trp Leu Phe Tyr Met Ser Asp Val Ser Ala Gly Gly 
     450                455                460
Ala Thr Val Phe Pro Glu Val Gly Ala Ser Val Trp Pro Lys Lys Gly 
 465                470                475                480
Thr Ala Val Phe Trp Tyr Asn Leu Phe Ala Ser Gly Glu Gly Asp Tyr 
                 485                490                495
Ser Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Asn Lys Trp Val 
             500                505                510
Ser Asn Lys Trp Leu His Glu Arg Gly Gln Glu Phe Arg Arg Pro Cys 
         515                520                525
Thr Leu Ser Glu Leu Glu 
     530



<210> 10090
<211> 2722
<212> DNA
<213> Homo sapiens
<308> M24487
<400> 10090

gagcgggct  agggtagga  gtagccgct  cgagtggag  cgactgggg  ctgaagagc  60
cgccgccct  tcgtcccac  ttccaggtg  gtgatcctg  aaaattaaa  cttccaaga  120
gatctggta  atattaatt  taggaattc  gcttcccca  tctttggct  atccaggct  180
ttttacttc  attggtcag  tgactgatt  gatccatac  gagaaagat  tggtgactt  240
tctgaaaga  tatattaag  cagaagagg  caagttaga  caaataaaa  aatgggcag  300
gaagttaga  cggctaact  gtacagcga  aaaagatcc  gaaggattt  ttgggcatc  360
agtaaatgc  ttcaaatta  tgaaacgtc  gaatactga  tggagtgag  tggagaatc  420
ggtccttaa  gatatgtca  atggcttta  ctctaacct  accattcag  gaccagtac  480
ttctaatga  gaagatcag  ttggggcag  caaagctct  ttacgtctc  aggatacct  540
caatttgga  acagatacc  tctcaaagg  taatcttcc  ggagtgaaa  acaaatctt  600
tctaacggc  gaggactgc  ttgagttgg  caaagtggc  tatacagaa  cagattatt  660
ccatacgga  ctgtggatg  aacaagccc  aaggcaact  gatgaaggc  agatttcta  720
catagataa  gtctctgtt  tagattatt  gagctatgc  gtatatcag  agggagacc  780
ggataaggc  cttttgctc  caaagaagc  tcttgaact  gatcctgaa  atcagagag  840
taatggtaa  ttaaaatat  ttgagtata  aatggctaa  gaaaaagat  tcaataagt  900
tgcttcaga  gaccaatct  atcagaaaa  tacaccaaa  aaaaaaggg  ttgctgtgg  960
ttacctgcc  gagagacag  agtacgaaa  gctgtgccg  ggggagggt  tcaaaatga  1020
ccctcggag  cagaaaaaa  tcttttgcc  ctaccatga  ggaaaccgt  atcctaaat  1080
tattctggc  ccagctaaa  aggaggatg  atgggacaa  cctcgtatt  ttcgcttcc  1140
tgatattat  tctgatgca  aaattgaaa  cgtcaaaga  ctagcaaaa  caaggctga  1200
gcgagccac  atttcaaac  caataacag  agacttgga  acggtacat  acagaattt  1260
taaaagtgc  tggctctct  gctatgaaa  tcctgtggt  tctcgaatt  atatgagaa  1320
acaagatct  acaggacta  atgtttcca  agcagagga  ttacaggta  caaattatg  1380
agttggagg  cagtatgaa  cccattttg  ctttgcacg  aaagatgag  cagatgctt  1440
caaagagct  gggacagga  atagaattg  tacatggct  ttttatatg  gtgatgtgt  1500
tgcaggagg  gccactgtt  ttcctgaag  tggagctag  gtttggccc  aaaaaggaa  1560
tgctgtttt  tggtataat  tgtttgcca  tggagaagg  gattatagt  cacggcatg  1620
agcctgtcc  gtgctagtt  gcaacaaat  ggtatccaa  aaatggctc  atgaacgtg  1680
acaagaatt  cgaagacct  gtacgttgt  agaattgga  tgacaaaca  gcttccctt  1740
ttctcctat  gttgtactc  tatgtgtct  atatacaca  ttccatagt  ttaactttc  1800
ggagtttac  attgactaa  actccatga  tgattcagt  atgaacctc  tcccatgtt  1860
catctgtgg  caattgctt  ctttgtggg  tcttttaaa  gtaacacga  atcatcata  1920
tgcataaaa  cttaaagtt  tgttggtat  acagaagac  aggcagagt  taaagtgag  1980
aattttata  ttaaagaac  ttttggttg  ataaaaaca  aatttgagc  tccagtttt  2040
gtatttcac  acatctcag  tggtgggtg  taagctaga  tgggctgtg  gataggaaa  2100
aaatgcctt  cagatgtgc  taggtgttc  gtttaccta  tgtcttact  tgttttctg  2160
atctgaaga  tagtaataa  ctaggacac  aactgggtt  catgtgatt  ccctttcat  2220
tgatcttct  agttgattt  tttcctccc  agtcttttt  aaagaaagt  tactgtatt  2280
taccaaccc  ctctctttt  ttttagctc  tctgtggtg  attaaacgt  cttgagtta  2340
aatatttcg  ttttttttt  ttttttaat  gaaagtcct  cataacaac  ctgggcctt  2400
ttaactaaa  tgctcacca  ttagcctgt  tttttatcc  ttttttaaa  tgacagatg  2460
ttttgttca  gaattttgc  gtttttctt  gtgctaata  cttgcctct  attcctgct  2520
cagcagggt  gtaatattg  cattctgat  aaatactgt  ccttaggag  ctggaagtt  2580
aaaaatgta  aagtccttt  agtgatgag  gaattgatt  tttttaaaa  tctttttct  2640
agaaagcca  aatgtttgt  tttttaaga  tctgaaatg  gttgtgaca  caatgacct  2700
tttatgatc  taaatcttt  tt  2722



<210> 10091
<211> 534
<212> PRT
<213> Homo sapiens
<308> P13674
<400> 10091

Met Ile Trp Tyr Ile Leu Ile Ile Gly Ile Leu Leu Pro Gln Ser Leu 
  1               5                  10                  15
Ala His Pro Gly Phe Phe Thr Ser Ile Gly Gln Met Thr Asp Leu Ile 
             20                  25                  30
His Thr Glu Lys Asp Leu Val Thr Ser Leu Lys Asp Tyr Ile Lys Ala 
         35                  40                  45
Glu Glu Asp Lys Leu Glu Gln Ile Lys Lys Trp Ala Glu Lys Leu Asp 
     50                  55                  60
Arg Leu Thr Ser Thr Ala Thr Lys Asp Pro Glu Gly Phe Val Gly His 
 65                  70                  75                  80
Pro Val Asn Ala Phe Lys Leu Met Lys Arg Leu Asn Thr Glu Trp Ser 
                 85                  90                  95
Glu Leu Glu Asn Leu Val Leu Lys Asp Met Ser Asp Gly Phe Ile Ser 
             100                105                110
Asn Leu Thr Ile Gln Arg Gln Tyr Phe Pro Asn Asp Glu Asp Gln Val 
         115                120                125
Gly Ala Ala Lys Ala Leu Leu Arg Leu Gln Asp Thr Tyr Asn Leu Asp 
     130                135                140
Thr Asp Thr Ile Ser Lys Gly Asn Leu Pro Gly Val Lys His Lys Ser 
 145                150                155                160
Phe Leu Thr Ala Glu Asp Cys Phe Glu Leu Gly Lys Val Ala Tyr Thr 
                 165                170                175
Glu Ala Asp Tyr Tyr His Thr Glu Leu Trp Met Glu Gln Ala Leu Arg 
             180                185                190
Gln Leu Asp Glu Gly Glu Ile Ser Thr Ile Asp Lys Val Ser Val Leu 
         195                200                205
Asp Tyr Leu Ser Tyr Ala Val Tyr Gln Gln Gly Asp Leu Asp Lys Ala 
     210                215                220
Leu Leu Leu Thr Lys Lys Leu Leu Glu Leu Asp Pro Glu His Gln Arg 
 225                230                235                240
Ala Asn Gly Asn Leu Lys Tyr Phe Glu Tyr Ile Met Ala Lys Glu Lys 
                 245                250                255
Asp Val Asn Lys Ser Ala Ser Asp Asp Gln Ser Asp Gln Lys Thr Thr 
             260                265                270
Pro Lys Lys Lys Gly Val Ala Val Asp Tyr Leu Pro Glu Arg Gln Lys 
         275                280                285
Tyr Glu Met Leu Cys Arg Gly Glu Gly Ile Lys Met Thr Pro Arg Arg 
     290                295                300
Gln Lys Lys Leu Phe Cys Arg Tyr His Asp Gly Asn Arg Asn Pro Lys 
 305                310                315                320
Phe Ile Leu Ala Pro Ala Lys Gln Glu Asp Glu Trp Asp Lys Pro Arg 
                 325                330                335
Ile Ile Arg Phe His Asp Ile Ile Ser Asp Ala Glu Ile Glu Ile Val 
             340                345                350
Lys Asp Leu Ala Lys Pro Arg Leu Arg Arg Ala Thr Ile Ser Asn Pro 
         355                360                365
Ile Thr Gly Asp Leu Glu Thr Val His Tyr Arg Ile Ser Lys Ser Ala 
     370                375                380
Trp Leu Ser Gly Tyr Glu Asn Pro Val Val Ser Arg Ile Asn Met Arg 
 385                390                395                400
Ile Gln Asp Leu Thr Gly Leu Asp Val Ser Thr Ala Glu Glu Leu Gln 
                 405                410                415
Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp Phe 
             420                425                430
Ala Arg Lys Asp Glu Pro Asp Ala Phe Lys Glu Leu Gly Thr Gly Asn 
         435                440                445
Arg Ile Ala Thr Trp Leu Phe Tyr Met Ser Asp Val Ser Ala Gly Gly 
     450                455                460
Ala Thr Val Phe Pro Glu Val Gly Ala Ser Val Trp Pro Lys Lys Gly 
 465                470                475                480
Thr Ala Val Phe Trp Tyr Asn Leu Phe Ala Ser Gly Glu Gly Asp Tyr 
                 485                490                495
Ser Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Asn Lys Trp Val 
             500                505                510
Ser Asn Lys Trp Leu His Glu Arg Gly Gln Glu Phe Arg Arg Pro Cys 
         515                520                525
Thr Leu Ser Glu Leu Glu 
     530



<210> 10092
<211> 5240
<212> DNA
<213> Rattus norvegicus
<308> X79321
<400> 10092

cctcccctg  ggaggttcg  gttcccgtg  ctcgcgcct  ctgcccgcc  gcctcgaga  60
cgcgctctc  cggccgcgg  gctcacagt  tccgccacc  accagctcc  gcaccagca  120
cagcgccgg  gccaccgcc  accttctgc  gtcgccgcc  ccacaacca  cttcccctc  180
gctgtcctc  tctgtcctc  cctcctgtc  attatcagg  tttgaagca  catggctga  240
ccccgccag  agtttgaca  aatggaaga  caggccgga  attacacta  gctccaaga  300
caagaagga  acatggacc  tggcttaaa  gctgaagaa  caggcatcg  agacacccc  360
aacatggag  accaagctg  tgggcatgt  actcaagct  gagtggccg  cgtaagcaa  420
gacaggaca  gaaatgacg  gaagaaagc  aagggggcc  atggcaaaa  gggggcgaa  480
atcgccaca  ctcggggag  agccactcc  ggccagaaa  gcacatcca  tgccaccag  540
atcccagcc  agaccacac  cagcccaaa  actcctcca  gatcaggtg  accaccaaa  600
tccggagaa  gaagcggct  cagcagccc  ggctcgccc  gaacccctg  cagtcgctc  660
cgtacccca  ccctaccaa  gccgcccac  cgagagccc  aaaaggtgg  agtggttcg  720
actccccct  agtcaccgt  tgccagtaa  agccgccta  agactgccc  tgtgcccat  780
ccagaccta  agaacgtca  gtccaagat  ggctccact  agaacctga  gcaccagcc  840
ggaggcggc  aggtgcaga  aattaataa  aagctggat  ttagcaacg  ccagtccaa  900
tgtggctca  aggacaata  caaacacgt  ccgggcgga  gcagtgtgc  aatagtcta  960
aagccagtg  acctgagca  ggtgacctc  aagtgtggt  ccttaggga  catccatca  1020
aagccagga  gtggccagg  agaagtaaa  tcagagaag  tggacttca  ggatagagt  1080
cagtcgaag  ttggctcct  ggataacat  acccatgtc  ctggaggag  gaataagaa  1140
attgaaacc  acaagctga  cttcaggga  aatgccaaa  ccaagacag  ccatggagc  1200
gaaatcgtg  acaagtcac  tgtggtgtc  ggggacaca  ctccacggc  cctcagcaa  1260
gtctcctcc  cgggcagca  cgacatggt  gactctcca  agcttgcca  gttagccga  1320
gaagtgtcc  cctctttgg  caagcaggg  ttgtgatca  gcccctggg  ccgtcactg  1380
tcatggaga  aagagagag  gagagtgtg  aaaaaaaaa  aaaaagaat  acctggccc  1440
tcaccctct  ccctccccg  tgctcctca  agacaggct  accagcttg  cacctaacc  1500
gcttttgtg  ctcgggttt  gctcgggac  tcaaaatca  tgatgggaa  aagtaaatt  1560
catctttcc  aattgattt  tgggctagt  ataaaatat  tttaaggaa  gaaaaaaaa  1620
acacgtaaa  ccatggcca  acaaaaccc  acatttcct  ggcaattgt  attgacccc  1680
cccccccct  tgagtttta  agggtgaag  aggctttgg  tagaggctg  ttctgggga  1740
tggctgagg  actagggca  ctaattgcc  acagcccca  cttaggggc  tcagggaca  1800
cggcagaca  gaaagactt  ggacttggt  tgtttgtgg  gccgtaagg  gtatgttaa  1860
tttgtgtgg  tttgaggga  gactgtgat  gtgaaggct  agagatggg  gggctggga  1920
tcagaggag  gaggtgagg  agacaggtt  ggagagggg  cattgcgtc  ttgccaagg  1980
gcttgggaa  cacaggtag  cctggctgc  gcagtctta  ctagcacag  tgcctgcct  2040
agaaagcac  gtggggtac  gtgggtgtg  gtgcccctt  tgaagggca  cccatggga  2100
aaggggtat  gggcagaag  aaggtaggc  ccagaaggt  gcaccttgt  gattggttc  2160
ctgaaggct  accttgcca  cccagggca  tgctcccac  ctccaggag  aggtctgag  2220
tgaggagct  ccttttcga  ctcacagga  aacctgtgt  actgagttc  gaagtttgg  2280
actacagcc  tgattttgg  caccataca  acctgggac  ttagggcta  ccagttctt  2340
gtaaggact  gtgcctctt  cgggaacat  tgcctgttc  caagcctgg  cctctggca  2400
ttctgcagt  gtgagggat  ggggtggta  tctgggatg  gggtcccag  cctcccatc  2460
ctcgcacag  cactgtatc  cctctacct  tcctatcat  cccacgtct  ccacgagag  2520
cagtcactg  cgtccgtac  tcacgtctc  ccgtcctga  tgcccagcc  cccaagccc  2580
atccctgga  ccctgggta  ttatggcca  tctgctcta  actaggggt  ggagtccag  2640
gaaggcaaa  atttgggcc  tggtctcta  tcctacgtt  ccagaatcc  accagtgtg  2700
ctcccacaa  gaaccttac  accttgttt  gtttgctcc  tcaggcgtt  ggcgccatc  2760
tggatggag  ccgtgtgtg  ctggagatt  ccctggaca  ctctgcttt  ttttttttt  2820
ctttagcgg  tgcctccta  gcctgactc  ttcccatgt  gaactggag  cagccaagt  2880
aggtgtcaa  gtcctggca  cagtatgaa  agtcagtag  cccagggca  ggccacact  2940
ctcccatct  ctgcttcca  cccagcttg  gattgctag  ctcccagag  tcagccgcc  3000
ttaagtccc  atgcacgta  tcagccctt  catacccca  tttggggaa  atacccctt  3060
attgaaatg  tttccctcc  gtcctatgg  agcggtgct  cctgcctgc  ggagcagcc  3120
gccatctca  agacgcagc  ctttctctc  tgtccgcac  ctgctgcgc  gtagtcgga  3180
tcgtctgtt  gtctgggtt  accagagtg  ctatgatag  gaaaagaaa  agaaaaaga  3240
aaaagaaaa  agaaaaaaa  aaaaggacg  atgttatct  gaaatattt  tcaaaaggt  3300
gtagcccac  gcagggatt  gagggcctg  tattccttg  cttcttcgt  acttaggtc  3360
aggccggtc  agtgctacc  tgctggaca  cccatgttt  gaagggttt  ttcttcatc  3420
gggacccct  cagacactg  attgtgaca  tggaggtct  tacattggc  aaggctgaa  3480
cacaggacc  gttagaggc  gcaggctcc  actgtcagg  agagcttgt  gctggcctg  3540
ttctctgag  gaagatggt  ctctctaat  acaacttca  gtcccacag  agccctggc  3600
gacatctaa  aactcctgc  tcacaagag  aaaggacac  agtaccagc  gggagagct  3660
tggccctag  aattccatg  ctctccact  ctatccgtg  gtcctttcc  agccttgcc  3720
cgtcaccaa  ggcttggga  ggactgccc  actgatgaa  gggacatct  tggagaccc  3780
cttggtttc  aaggcgtca  ccccctgac  ttgcatgac  tcctacagc  gaaggatga  3840
gcctttaaa  attaggaac  tcaggccca  gtcggccac  ttgggcttg  gtacagtta  3900
ggacgatgc  gtagaagga  gtggccaac  tttccatat  agagttctg  gtgcccaga  3960
ctaccctat  gtgagctcc  cactgctga  ggactttag  tgtccttag  agtgaagag  4020
ccaacggag  aaaaggaag  gtggtttga  ggtctgtgg  cccttcatc  tggttacct  4080
ttgtggttt  ctctgtata  ccccattta  ccatcctgc  gttcctgtc  ttgaatagg  4140
gtgggggta  tctgccata  ctcttgtag  cagtcagcc  ccaagtcat  gtttggagt  4200
atctggtca  tgctaatag  cagtttaca  ggaattctg  cttgttact  cagtgagga  4260
aatccccca  ggccctggc  cctgtcctg  ctttccatg  ctctccact  cagagccaa  4320
gtctttggg  gggctagat  gggtgtaca  tttgcctgg  acctccaag  tcttaatcc  4380
ctttatcaa  agttccatt  aaattgact  caatataag  gtgtatcca  ttgagattg  4440
ttgtgttgt  gggtaaagg  gggaggagg  acatgttaa  ataattgac  tgggcaagg  4500
gaagtcttg  agtgtagca  ttaaaccat  ttgtagccc  attcatgat  ttgaccact  4560
gctagagag  agaggtgcc  taaggctag  acctagagg  ttggctgtc  accaacagg  4620
aggcttttg  aaggcagag  cagccagct  ggtccctga  ttcccagcc  ggtgcagct  4680
taagaactg  tcttgcctg  tgccttctt  tggtgtcca  agcccacag  caatgcctc  4740
tcaaaaccc  ggcttcctt  cttctaatc  actggcaca  cagcatcac  tccggattg  4800
cttcagatc  acagcctac  ctactagca  tgggtaaga  cacttcctt  gtccttgtc  4860
gttctccag  aaagtgggc  tggaggcgg  gttaataac  ataggtctg  ggctttatg  4920
gccttcaaa  ttctctcta  cttctgaaa  ggttacttt  gggcagtat  gcagtctca  4980
cctccgatg  ctgtagcct  tgcagttgc  gtactgggc  tgatctcca  tgcttgcaa  5040
tcccatgat  tctttggtg  tttgagggt  gggggaggg  catgaatca  cttagctta  5100
cttcctgtc  gtgaatgtc  atatagtgt  ctgtgtttt  acaaacgat  tacactgac  5160
gttgctgta  aagtgaatt  ggaaataaa  ttattactc  gattaaaca  aaaaaaaaa  5220
aaaaaaaaa  aaaaaaaaaa  5240



<210> 10093
<211> 751
<212> PRT
<213> Rattus norvegicus
<308> P19332
<400> 10093

Ala Glu Pro Arg Gln Glu Phe Asp Thr Met Glu Asp Gln Ala Gly Asp 
  1               5                  10                  15
Tyr Thr Met Leu Gln Asp Gln Glu Gly Asp Met Asp His Gly Leu Lys 
             20                  25                  30
Glu Ser Pro Pro Gln Pro Pro Ala Asp Asp Gly Ser Glu Glu Pro Gly 
         35                  40                  45
Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr 
     50                  55                  60
Ala Pro Leu Val Glu Glu Arg Ala Pro Asp Lys Gln Ala Thr Ala Gln 
 65                  70                  75                  80
Ser His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile 
                 85                  90                  95
Gly Asp Thr Pro Asn Met Glu Asp Gln Ala Ala Gly His Val Thr Gln 
             100                105                110
Glu Pro Gln Lys Val Glu Ile Phe Ser Gln Ser Leu Leu Val Glu Pro 
         115                120                125
Gly Arg Arg Glu Gly Gln Ala Pro Asp Ser Gly Ile Ser Asp Trp Thr 
     130                135                140
His Gln Gln Val Pro Ser Met Ser Gly Ala Pro Leu Pro Pro Gln Gly 
 145                150                155                160
Leu Arg Glu Ala Thr His Gln Pro Leu Gly Thr Arg Pro Glu Asp Val 
                 165                170                175
Glu Arg Ser His Pro Ala Ser Glu Leu Leu Trp Gln Glu Ser Pro Gln 
             180                185                190
Lys Glu Ala Trp Gly Lys Asp Arg Leu Gly Ser Glu Glu Glu Val Asp 
         195                200                205
Glu Asp Ile Thr Met Asp Glu Ser Ser Gln Glu Ser Pro Pro Ser Gln 
     210                215                220
Ala Ser Leu Ala Pro Gly Thr Ala Thr Pro Gln Ala Arg Ser Val Ser 
 225                230                235                240
Ala Ser Gly Val Ser Gly Glu Thr Thr Ser Ile Pro Gly Phe Pro Ala 
                 245                250                255
Glu Gly Ser Ile Pro Leu Pro Ala Asp Phe Phe Ser Lys Val Ser Ala 
             260                265                270
Glu Thr Gln Ala Ser Pro Pro Glu Gly Pro Gly Thr Gly Pro Ser Glu 
         275                280                285
Glu Gly His Glu Ala Ala Pro Glu Phe Thr Phe His Val Glu Ile Lys 
     290                295                300
Ala Ser Ala Pro Lys Glu Gln Asp Leu Glu Gly Ala Thr Val Val Gly 
 305                310                315                320
Ala Pro Ala Glu Glu Gln Lys Ala Arg Gly Pro Ser Val Gly Lys Gly 
                 325                330                335
Thr Lys Glu Ala Ser Leu Leu Glu Pro Thr Asp Lys Gln Pro Ala Ala 
             340                345                350
Gly Leu Pro Gly Arg Pro Val Ser Arg Val Pro Gln Leu Lys Ala Arg 
         355                360                365
Val Ala Gly Val Ser Lys Asp Arg Thr Gly Asn Asp Glu Lys Lys Ala 
     370                375                380
Lys Thr Ser Thr Pro Ser Cys Ala Lys Thr Pro Ser Asn Arg Pro Cys 
 385                390                395                400
Leu Ser Pro Thr Arg Pro Thr Pro Gly Ser Ser Asp Pro Leu Ile Lys 
                 405                410                415
Pro Ser Ser Pro Ala Val Cys Pro Glu Pro Ala Thr Ser Pro Lys Tyr 
             420                425                430
Val Ser Ser Val Thr Pro Arg Asn Gly Ser Pro Gly Thr Lys Gln Met 
         435                440                445
Lys Leu Lys Gly Ala Asp Gly Lys Thr Gly Ala Lys Ile Ala Thr Pro 
     450                455                460
Arg Gly Ala Ala Thr Pro Gly Gln Lys Gly Thr Ser Asn Ala Thr Arg 
 465                470                475                480
Ile Pro Ala Lys Thr Thr Pro Ser Pro Lys Thr Pro Pro Gly Ser Gly 
                 485                490                495
Glu Pro Pro Lys Ser Gly Glu Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
             500                505                510
Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
         515                520                525
Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
     530                535                540
Ser Pro Ser Ala Ser Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
 545                550                555                560
Pro Asp Leu Lys Asn Val Arg Ser Lys Ile Gly Ser Thr Glu Asn Leu 
                 565                570                575
Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu 
             580                585                590
Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
         595                600                605
His Val Pro Gly Gly Gly Ser Val His Ile Val Tyr Lys Pro Val Asp 
     610                615                620
Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His 
 625                630                635                640
Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
                 645                650                655
Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His 
             660                665                670
Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
         675                680                685
Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr 
     690                695                700
Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn 
 705                710                715                720
Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala 
                 725                730                735
Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
             740                745                750



<210> 10094
<211> 2296
<212> DNA
<213> Homo sapiens
<308> AF456477
<400> 10094

gcggccgcg  cgaccatgt  tcttgaaat  cttgtaaag  ggtttctaa  ccaccctca  60
gaggtgtct  tcaccccca  actgggact  gtgtggcct  tgtggtgcc  ccctgctgg  120
gcctcccaa  ttttgaaag  ctttcctca  cacctggga  ccaacagag  ccagcttct  180
gcagctaag  aggccgttc  gctgtgacg  aggcctgaa  cacaggatt  ggactgaag  240
gatgatgtc  ccttcccta  ttccccttg  ggctccctg  gtcagggca  agactaggt  300
ttgtggctg  tctggcttg  ggcgcgagg  tggttctct  tggtcatag  ccgaagtct  360
atggcagtc  caaaggagg  ttacaactc  tgcatcaca  gaaaaagga  gccactgcc  420
gctgggggg  tctgcagct  ccagaagct  cgtgagcct  agccacccc  cagactggg  480
tcctctcca  gctcgccct  tggaggggc  gcgcagcct  ccaccaagg  ccctgcgac  540
acagcaggg  ttgggatga  ttgcctgtc  tggatctgc  ctagaggcc  aagctgcct  600
cctgaggaa  gatgacttg  caagtcagg  gacactgtt  ccaaagcct  gaccagagc  660
cctcagccc  ctgaccttg  acaaactcc  tctgctgcc  tgagaaaag  gaagccgcc  720
ttgcaaaac  ttgctgcct  aagaaactc  gcagcctca  gcccaattc  gccacttct  780
gtttgggta  agttaaagg  aaccctgag  gacttggca  tagaaatcc  gggcctccc  840
tggggctgg  agcttcgtg  gcagctaga  ctttacctg  aaggaagtc  ctgggccca  900
aactctcca  caagagcct  cctgccgtt  gctgagtcc  agcaattct  ctaagttga  960
gggatctga  aaggagaag  aaatgtggg  tagatttgg  ggtggttag  gatatgccc  1020
cctcattac  gccaacagt  tcggctgca  ttcttcacg  acctcggtt  ctcttcctg  1080
agttcttgt  ccctgctct  cagcaccat  ggccttctt  tacggaagg  tctgggatc  1140
cccccttgt  ggggcaggc  cttggggcc  gcctaagat  atggtttag  gtgatcagt  1200
ctggcagat  aattgaaaa  gcacgctgg  ttgtgatct  aaatgagga  aatcccccc  1260
gggctgggc  ctcctcccc  cccctcact  ctcccacct  cagagccag  gtccttggg  1320
gggctagat  ggatatact  tatgccggc  ccttcaagc  gctgactca  tttatcaat  1380
gttccattt  aattgactt  agtggtgag  ctgtatcct  tttgctatt  cttgttgtg  1440
tatgggggg  ggggggagg  atgtgtaag  tagttaaca  gggcaaagg  agatcttgg  1500
gtgcagcac  taaactgcc  cgtaaccct  ttcatgatt  caaccacat  tgctagagg  1560
agggagcag  cacggagtt  gaggccctt  gggtttctc  tttccactg  caggctttc  1620
caggcagct  gctagttca  tccctcccc  gccaggtgc  ggcgtagga  tatggacat  1680
tggttgctt  ggcctgctg  cctctttca  gggtcctaa  cccacaatc  tgcctccct  1740
agaccttgg  atccttccc  ctaagccgt  ggcacctct  tgccacctc  cacactggc  1800
ccagacaca  agcctgtgc  tttggagct  agatcactc  cttcaccct  ctcatcttt  1860
ttctccaag  aaagccacg  ggtcggggc  agggcagag  tgatcacct  cgtgtccca  1920
ctacagacc  gcggcttca  aaaacttct  atttctctt  agctttgaa  agggttacc  1980
tgggcactg  cctagagcc  cacctccta  tagacttag  cccatgagt  tgccatgtt  2040
agcaggact  tttctggca  ttgcaagtc  catgatttc  tcggtaatt  tgagggtgg  2100
gggagggac  tgaaatcat  ttagcttag  tttctgtct  tgaatgtct  tatagtgta  2160
tgtgtgttt  aacaaatga  ttacactga  tgttgctgt  aaagtgaat  tggaaataa  2220
gttattact  tgattaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2280
aaaaaaaaa  aaaaaa  2296



<210> 10095
<211> 383
<212> PRT
<213> Homo sapiens
<308> NP_058518
<400> 10095

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
  1               5                  10                  15
Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
             20                  25                  30
Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu Ala 
         35                  40                  45
Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
     50                  55                  60
Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
 65                  70                  75                  80
Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
                 85                  90                  95
Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
             100                105                110
Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
         115                120                125
Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
     130                135                140
Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
 145                150                155                160
Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
                 165                170                175
Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
             180                185                190
Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu 
         195                200                205
Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu 
     210                215                220
Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
 225                230                235                240
His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp 
                 245                250                255
Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His 
             260                265                270
Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
         275                280                285
Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His 
     290                295                300
Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
 305                310                315                320
Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr 
                 325                330                335
Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn 
             340                345                350
Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala 
         355                360                365
Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
     370                375                380



<210> 10096
<211> 1374
<212> DNA
<213> Rattus norvegicus
<308> X80130
<400> 10096

aggcctgcc  ccagcgcca  cccagctga  cccagccgc  caaagcacg  ctacagatc  60
cacagaagc  gtaccagga  gtgtgacga  gaggagacc  cagctttgg  gtgcgacaa  120
ggctccgga  tggtgaagg  tggctttgc  ggtgatgat  ctcccagag  tgtcttccc  180
tccatcgtg  gtcgcccac  ccaccaggg  gtcatggta  gtatggggc  gaaagactc  240
tatgtaggt  acgaggctc  gagcaagcg  ggcatcctg  ctctgaagt  ccccataga  300
cacggcatt  tcaccaact  ggacgacat  gagaagatc  ggcaccaca  cttctacaa  360
gagctccgt  tggcccctg  ggagcaccc  accctgctc  ctgaggccc  actgaaccc  420
aaggccaac  gtgagaaga  gacacagat  atgtttgag  ccttcaatg  gcctgccat  480
tatgtggcc  tccaggcgg  gctgtccct  tacgcttct  ggagaacca  aggcattgt  540
ctggattct  gcgacggtg  gactcataa  gtccccatc  atgagggtt  tgccttacc  600
catgccatc  tgcgtctgg  tctagctgg  cgggacctc  ctgactacc  tatgaagat  660
ctcactgag  gcgggtact  ctttgtcac  accgctgaa  gtgaaattg  ccgagacat  720
aaagaaaaa  tgtgttatg  cgccctgga  tttgagaat  agatggcca  cgctgcatc  780
tcctcctct  tggagaaga  ctacgaact  cccgatggc  aggtcatca  cattggcaa  840
gagcgtttc  gctgtcctg  gactctctt  cagccctct  tcattggta  ggagtctgc  900
ggcattcac  aaactactt  taacagcat  atgaagtgt  acatcgata  ccgcaaaga  960
ctgtacgcc  acaatgtcc  gtctggagg  accaccatg  accctggga  tgctgatcg  1020
atgcaaaag  aaataactg  actggctcc  agcaccatg  agattaaga  tattgctcc  1080
cctgagcgt  aatactctg  ctggattgg  ggctccatc  tggcctctc  gtctacctt  1140
caacaaatg  ggatcagca  gcaagagta  gatgaggcc  ggccctcca  tgtccaccg  1200
aagtgcttc  gaggcggct  ccttacact  aggacgaca  tattgtgct  ggaatcctc  1260
gaggccctc  cccatctcc  atcagtcat  gtacagttt  tttacacac  tgcagtttg  1320
ttgtgcttc  aatatttat  gctttataa  taaaccaga  caggacttg  aacc  1374



<210> 10097
<211> 377
<212> PRT
<213> Rattus norvegicus
<308> CAA56429
<400> 10097

Met Cys Asp Asp Glu Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
  1               5                  10                  15
Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
             20                  25                  30
Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
         35                  40                  45
Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
     50                  55                  60
Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
 65                  70                  75                  80
Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                 85                  90                  95
Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
             100                105                110
Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
         115                120                125
Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
     130                135                140
Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
 145                150                155                160
Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                 165                170                175
Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
             180                185                190
Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
         195                200                205
Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
     210                215                220
Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
 225                230                235                240
Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                 245                250                255
Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
             260                265                270
Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
         275                280                285
Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
     290                295                300
Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
 305                310                315                320
Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                 325                330                335
Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
             340                345                350
Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
         355                360                365
Pro Ser Ile Val His Arg Lys Cys Phe 
     370                375



<210> 10098
<211> 1294
<212> DNA
<213> Homo sapiens
<308> NM_005159
<400> 10098

atgtgtgac  acgaggaga  caccgccct  gtgtgcgac  acggctctg  gctggtgaa  60
gccggcttt  cgggcgatg  cgcgccccg  gctgtcttc  cgtccatcg  gggccgccc  120
cggcaccag  gagttatgg  gggtatggg  cagaaggac  cctacgtag  tgatgaagc  180
cagagcaag  gaggcatcc  gaccctgaa  tatcccatc  agcatggta  catcaccaa  240
tgggacgac  tggagaaga  ctggcacca  accttctac  atgagctcc  tgttgctcc  300
gaggagcac  ccaccctgc  cacagaggc  ccgctgaac  ccaaggcca  ccgggagaa  360
atgactcag  tcatgtttg  gaccttcaa  gtccctgcc  tgtacgtgg  catccaggc  420
gtgctatcc  tgtatgctt  tggccgtac  acaggcatt  ttctggact  tggggatgg  480
gtaactcac  atgtcccca  ctatgaggg  tacgctttg  cccatgcca  catgcgtct  540
gatctggct  gtcgggacc  cactgacta  ctcatgaag  tcctcactg  gcgtggcta  600
tcctttgtc  ccactgctg  acgtgaaat  gtccgtgac  ttaaagaga  gctgtgcta  660
gtcgccctg  attttgaga  tgagatggc  acagctgcc  cttcctcct  cttggagaa  720
agctatgaa  tgcctgatg  ccaagtcat  actatcggc  atgagcgct  ccgctgtcc  780
gagacactc  tccagccct  cttcattgg  atggaatct  ctggcatcc  tgaaacaac  840
tacaatagc  tcatgaagt  tgacattga  atccgcaag  acctgtatg  caacaatgt  900
ttatctgga  gcaccacta  gtaccctgg  attgctgat  gtatgcaga  ggaaatcac  960
gctctggct  ctagcacca  gaagattaa  attattgct  cccctgagc  taaatactc  1020
gtctggatt  ggggctcca  cttggcctc  ctgtccacc  tccagcaaa  gtggattag  1080
aagcaagag  acgatgagg  aggcccatc  attgtccac  gcaaatgct  ctaagatgc  1140
ttctctctc  atctacctt  cagtcagga  gacggtatt  tgcttcttg  agtctccca  1200
accaccttc  ctcatcttt  atcaatcat  gtacagttt  tttacacac  tgcaatttg  1260
ttgtgcttc  aatatttat  gctttataa  taaa  1294



<210> 10099
<211> 377
<212> PRT
<213> Homo sapiens
<308> P04270
<400> 10099

Met Cys Asp Asp Glu Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
  1               5                  10                  15
Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
             20                  25                  30
Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
         35                  40                  45
Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
     50                  55                  60
Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
 65                  70                  75                  80
Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                 85                  90                  95
Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
             100                105                110
Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
         115                120                125
Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
     130                135                140
Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
 145                150                155                160
Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                 165                170                175
Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
             180                185                190
Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
         195                200                205
Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
     210                215                220
Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
 225                230                235                240
Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                 245                250                255
Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
             260                265                270
Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
         275                280                285
Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
     290                295                300
Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
 305                310                315                320
Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                 325                330                335
Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
             340                345                350
Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
         355                360                365
Pro Ser Ile Val His Arg Lys Cys Phe 
     370                375



<210> 10100
<211> 1374
<212> DNA
<213> Rattus norvegicus
<308> X80130
<400> 10100

aggcctgcc  ccagcgcca  cccagctga  cccagccgc  caaagcacg  ctacagatc  60
cacagaagc  gtaccagga  gtgtgacga  gaggagacc  cagctttgg  gtgcgacaa  120
ggctccgga  tggtgaagg  tggctttgc  ggtgatgat  ctcccagag  tgtcttccc  180
tccatcgtg  gtcgcccac  ccaccaggg  gtcatggta  gtatggggc  gaaagactc  240
tatgtaggt  acgaggctc  gagcaagcg  ggcatcctg  ctctgaagt  ccccataga  300
cacggcatt  tcaccaact  ggacgacat  gagaagatc  ggcaccaca  cttctacaa  360
gagctccgt  tggcccctg  ggagcaccc  accctgctc  ctgaggccc  actgaaccc  420
aaggccaac  gtgagaaga  gacacagat  atgtttgag  ccttcaatg  gcctgccat  480
tatgtggcc  tccaggcgg  gctgtccct  tacgcttct  ggagaacca  aggcattgt  540
ctggattct  gcgacggtg  gactcataa  gtccccatc  atgagggtt  tgccttacc  600
catgccatc  tgcgtctgg  tctagctgg  cgggacctc  ctgactacc  tatgaagat  660
ctcactgag  gcgggtact  ctttgtcac  accgctgaa  gtgaaattg  ccgagacat  720
aaagaaaaa  tgtgttatg  cgccctgga  tttgagaat  agatggcca  cgctgcatc  780
tcctcctct  tggagaaga  ctacgaact  cccgatggc  aggtcatca  cattggcaa  840
gagcgtttc  gctgtcctg  gactctctt  cagccctct  tcattggta  ggagtctgc  900
ggcattcac  aaactactt  taacagcat  atgaagtgt  acatcgata  ccgcaaaga  960
ctgtacgcc  acaatgtcc  gtctggagg  accaccatg  accctggga  tgctgatcg  1020
atgcaaaag  aaataactg  actggctcc  agcaccatg  agattaaga  tattgctcc  1080
cctgagcgt  aatactctg  ctggattgg  ggctccatc  tggcctctc  gtctacctt  1140
caacaaatg  ggatcagca  gcaagagta  gatgaggcc  ggccctcca  tgtccaccg  1200
aagtgcttc  gaggcggct  ccttacact  aggacgaca  tattgtgct  ggaatcctc  1260
gaggccctc  cccatctcc  atcagtcat  gtacagttt  tttacacac  tgcagtttg  1320
ttgtgcttc  aatatttat  gctttataa  taaaccaga  caggacttg  aacc  1374



<210> 10101
<211> 377
<212> PRT
<213> Rattus norvegicus
<308> CAA56429
<400> 10101

Met Cys Asp Asp Glu Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
  1               5                  10                  15
Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
             20                  25                  30
Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
         35                  40                  45
Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
     50                  55                  60
Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
 65                  70                  75                  80
Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                 85                  90                  95
Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
             100                105                110
Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
         115                120                125
Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
     130                135                140
Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
 145                150                155                160
Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                 165                170                175
Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
             180                185                190
Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
         195                200                205
Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
     210                215                220
Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
 225                230                235                240
Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                 245                250                255
Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
             260                265                270
Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
         275                280                285
Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
     290                295                300
Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
 305                310                315                320
Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                 325                330                335
Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
             340                345                350
Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
         355                360                365
Pro Ser Ile Val His Arg Lys Cys Phe 
     370                375



<210> 10102
<211> 1294
<212> DNA
<213> Homo sapiens
<308> NM_005159
<400> 10102

atgtgtgac  acgaggaga  caccgccct  gtgtgcgac  acggctctg  gctggtgaa  60
gccggcttt  cgggcgatg  cgcgccccg  gctgtcttc  cgtccatcg  gggccgccc  120
cggcaccag  gagttatgg  gggtatggg  cagaaggac  cctacgtag  tgatgaagc  180
cagagcaag  gaggcatcc  gaccctgaa  tatcccatc  agcatggta  catcaccaa  240
tgggacgac  tggagaaga  ctggcacca  accttctac  atgagctcc  tgttgctcc  300
gaggagcac  ccaccctgc  cacagaggc  ccgctgaac  ccaaggcca  ccgggagaa  360
atgactcag  tcatgtttg  gaccttcaa  gtccctgcc  tgtacgtgg  catccaggc  420
gtgctatcc  tgtatgctt  tggccgtac  acaggcatt  ttctggact  tggggatgg  480
gtaactcac  atgtcccca  ctatgaggg  tacgctttg  cccatgcca  catgcgtct  540
gatctggct  gtcgggacc  cactgacta  ctcatgaag  tcctcactg  gcgtggcta  600
tcctttgtc  ccactgctg  acgtgaaat  gtccgtgac  ttaaagaga  gctgtgcta  660
gtcgccctg  attttgaga  tgagatggc  acagctgcc  cttcctcct  cttggagaa  720
agctatgaa  tgcctgatg  ccaagtcat  actatcggc  atgagcgct  ccgctgtcc  780
gagacactc  tccagccct  cttcattgg  atggaatct  ctggcatcc  tgaaacaac  840
tacaatagc  tcatgaagt  tgacattga  atccgcaag  acctgtatg  caacaatgt  900
ttatctgga  gcaccacta  gtaccctgg  attgctgat  gtatgcaga  ggaaatcac  960
gctctggct  ctagcacca  gaagattaa  attattgct  cccctgagc  taaatactc  1020
gtctggatt  ggggctcca  cttggcctc  ctgtccacc  tccagcaaa  gtggattag  1080
aagcaagag  acgatgagg  aggcccatc  attgtccac  gcaaatgct  ctaagatgc  1140
ttctctctc  atctacctt  cagtcagga  gacggtatt  tgcttcttg  agtctccca  1200
accaccttc  ctcatcttt  atcaatcat  gtacagttt  tttacacac  tgcaatttg  1260
ttgtgcttc  aatatttat  gctttataa  taaa  1294



<210> 10103
<211> 377
<212> PRT
<213> Homo sapiens
<308> P04270
<400> 10103

Met Cys Asp Asp Glu Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
  1               5                  10                  15
Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
             20                  25                  30
Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
         35                  40                  45
Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
     50                  55                  60
Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
 65                  70                  75                  80
Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                 85                  90                  95
Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
             100                105                110
Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
         115                120                125
Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
     130                135                140
Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
 145                150                155                160
Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                 165                170                175
Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
             180                185                190
Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
         195                200                205
Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
     210                215                220
Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
 225                230                235                240
Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                 245                250                255
Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
             260                265                270
Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
         275                280                285
Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
     290                295                300
Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
 305                310                315                320
Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                 325                330                335
Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
             340                345                350
Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
         355                360                365
Pro Ser Ile Val His Arg Lys Cys Phe 
     370                375



<210> 10104
<211> 1374
<212> DNA
<213> Rattus norvegicus
<308> X80130
<400> 10104

aggcctgcc  ccagcgcca  cccagctga  cccagccgc  caaagcacg  ctacagatc  60
cacagaagc  gtaccagga  gtgtgacga  gaggagacc  cagctttgg  gtgcgacaa  120
ggctccgga  tggtgaagg  tggctttgc  ggtgatgat  ctcccagag  tgtcttccc  180
tccatcgtg  gtcgcccac  ccaccaggg  gtcatggta  gtatggggc  gaaagactc  240
tatgtaggt  acgaggctc  gagcaagcg  ggcatcctg  ctctgaagt  ccccataga  300
cacggcatt  tcaccaact  ggacgacat  gagaagatc  ggcaccaca  cttctacaa  360
gagctccgt  tggcccctg  ggagcaccc  accctgctc  ctgaggccc  actgaaccc  420
aaggccaac  gtgagaaga  gacacagat  atgtttgag  ccttcaatg  gcctgccat  480
tatgtggcc  tccaggcgg  gctgtccct  tacgcttct  ggagaacca  aggcattgt  540
ctggattct  gcgacggtg  gactcataa  gtccccatc  atgagggtt  tgccttacc  600
catgccatc  tgcgtctgg  tctagctgg  cgggacctc  ctgactacc  tatgaagat  660
ctcactgag  gcgggtact  ctttgtcac  accgctgaa  gtgaaattg  ccgagacat  720
aaagaaaaa  tgtgttatg  cgccctgga  tttgagaat  agatggcca  cgctgcatc  780
tcctcctct  tggagaaga  ctacgaact  cccgatggc  aggtcatca  cattggcaa  840
gagcgtttc  gctgtcctg  gactctctt  cagccctct  tcattggta  ggagtctgc  900
ggcattcac  aaactactt  taacagcat  atgaagtgt  acatcgata  ccgcaaaga  960
ctgtacgcc  acaatgtcc  gtctggagg  accaccatg  accctggga  tgctgatcg  1020
atgcaaaag  aaataactg  actggctcc  agcaccatg  agattaaga  tattgctcc  1080
cctgagcgt  aatactctg  ctggattgg  ggctccatc  tggcctctc  gtctacctt  1140
caacaaatg  ggatcagca  gcaagagta  gatgaggcc  ggccctcca  tgtccaccg  1200
aagtgcttc  gaggcggct  ccttacact  aggacgaca  tattgtgct  ggaatcctc  1260
gaggccctc  cccatctcc  atcagtcat  gtacagttt  tttacacac  tgcagtttg  1320
ttgtgcttc  aatatttat  gctttataa  taaaccaga  caggacttg  aacc  1374



<210> 10105
<211> 377
<212> PRT
<213> Rattus norvegicus
<308> CAA56429
<400> 10105

Met Cys Asp Asp Glu Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
  1               5                  10                  15
Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
             20                  25                  30
Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
         35                  40                  45
Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
     50                  55                  60
Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
 65                  70                  75                  80
Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                 85                  90                  95
Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
             100                105                110
Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
         115                120                125
Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
     130                135                140
Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
 145                150                155                160
Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                 165                170                175
Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
             180                185                190
Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
         195                200                205
Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
     210                215                220
Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
 225                230                235                240
Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                 245                250                255
Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
             260                265                270
Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
         275                280                285
Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
     290                295                300
Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
 305                310                315                320
Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                 325                330                335
Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
             340                345                350
Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
         355                360                365
Pro Ser Ile Val His Arg Lys Cys Phe 
     370                375



<210> 10106
<211> 1294
<212> DNA
<213> Homo sapiens
<308> NM_005159
<400> 10106

atgtgtgac  acgaggaga  caccgccct  gtgtgcgac  acggctctg  gctggtgaa  60
gccggcttt  cgggcgatg  cgcgccccg  gctgtcttc  cgtccatcg  gggccgccc  120
cggcaccag  gagttatgg  gggtatggg  cagaaggac  cctacgtag  tgatgaagc  180
cagagcaag  gaggcatcc  gaccctgaa  tatcccatc  agcatggta  catcaccaa  240
tgggacgac  tggagaaga  ctggcacca  accttctac  atgagctcc  tgttgctcc  300
gaggagcac  ccaccctgc  cacagaggc  ccgctgaac  ccaaggcca  ccgggagaa  360
atgactcag  tcatgtttg  gaccttcaa  gtccctgcc  tgtacgtgg  catccaggc  420
gtgctatcc  tgtatgctt  tggccgtac  acaggcatt  ttctggact  tggggatgg  480
gtaactcac  atgtcccca  ctatgaggg  tacgctttg  cccatgcca  catgcgtct  540
gatctggct  gtcgggacc  cactgacta  ctcatgaag  tcctcactg  gcgtggcta  600
tcctttgtc  ccactgctg  acgtgaaat  gtccgtgac  ttaaagaga  gctgtgcta  660
gtcgccctg  attttgaga  tgagatggc  acagctgcc  cttcctcct  cttggagaa  720
agctatgaa  tgcctgatg  ccaagtcat  actatcggc  atgagcgct  ccgctgtcc  780
gagacactc  tccagccct  cttcattgg  atggaatct  ctggcatcc  tgaaacaac  840
tacaatagc  tcatgaagt  tgacattga  atccgcaag  acctgtatg  caacaatgt  900
ttatctgga  gcaccacta  gtaccctgg  attgctgat  gtatgcaga  ggaaatcac  960
gctctggct  ctagcacca  gaagattaa  attattgct  cccctgagc  taaatactc  1020
gtctggatt  ggggctcca  cttggcctc  ctgtccacc  tccagcaaa  gtggattag  1080
aagcaagag  acgatgagg  aggcccatc  attgtccac  gcaaatgct  ctaagatgc  1140
ttctctctc  atctacctt  cagtcagga  gacggtatt  tgcttcttg  agtctccca  1200
accaccttc  ctcatcttt  atcaatcat  gtacagttt  tttacacac  tgcaatttg  1260
ttgtgcttc  aatatttat  gctttataa  taaa  1294



<210> 10107
<211> 377
<212> PRT
<213> Homo sapiens
<308> P04270
<400> 10107

Met Cys Asp Asp Glu Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
  1               5                  10                  15
Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
             20                  25                  30
Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
         35                  40                  45
Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
     50                  55                  60
Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
 65                  70                  75                  80
Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                 85                  90                  95
Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
             100                105                110
Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
         115                120                125
Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
     130                135                140
Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
 145                150                155                160
Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                 165                170                175
Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
             180                185                190
Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
         195                200                205
Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
     210                215                220
Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
 225                230                235                240
Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                 245                250                255
Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
             260                265                270
Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
         275                280                285
Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
     290                295                300
Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
 305                310                315                320
Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                 325                330                335
Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
             340                345                350
Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
         355                360                365
Pro Ser Ile Val His Arg Lys Cys Phe 
     370                375



<210> 10108
<211> 1374
<212> DNA
<213> Rattus norvegicus
<308> X80130
<400> 10108

aggcctgcc  ccagcgcca  cccagctga  cccagccgc  caaagcacg  ctacagatc  60
cacagaagc  gtaccagga  gtgtgacga  gaggagacc  cagctttgg  gtgcgacaa  120
ggctccgga  tggtgaagg  tggctttgc  ggtgatgat  ctcccagag  tgtcttccc  180
tccatcgtg  gtcgcccac  ccaccaggg  gtcatggta  gtatggggc  gaaagactc  240
tatgtaggt  acgaggctc  gagcaagcg  ggcatcctg  ctctgaagt  ccccataga  300
cacggcatt  tcaccaact  ggacgacat  gagaagatc  ggcaccaca  cttctacaa  360
gagctccgt  tggcccctg  ggagcaccc  accctgctc  ctgaggccc  actgaaccc  420
aaggccaac  gtgagaaga  gacacagat  atgtttgag  ccttcaatg  gcctgccat  480
tatgtggcc  tccaggcgg  gctgtccct  tacgcttct  ggagaacca  aggcattgt  540
ctggattct  gcgacggtg  gactcataa  gtccccatc  atgagggtt  tgccttacc  600
catgccatc  tgcgtctgg  tctagctgg  cgggacctc  ctgactacc  tatgaagat  660
ctcactgag  gcgggtact  ctttgtcac  accgctgaa  gtgaaattg  ccgagacat  720
aaagaaaaa  tgtgttatg  cgccctgga  tttgagaat  agatggcca  cgctgcatc  780
tcctcctct  tggagaaga  ctacgaact  cccgatggc  aggtcatca  cattggcaa  840
gagcgtttc  gctgtcctg  gactctctt  cagccctct  tcattggta  ggagtctgc  900
ggcattcac  aaactactt  taacagcat  atgaagtgt  acatcgata  ccgcaaaga  960
ctgtacgcc  acaatgtcc  gtctggagg  accaccatg  accctggga  tgctgatcg  1020
atgcaaaag  aaataactg  actggctcc  agcaccatg  agattaaga  tattgctcc  1080
cctgagcgt  aatactctg  ctggattgg  ggctccatc  tggcctctc  gtctacctt  1140
caacaaatg  ggatcagca  gcaagagta  gatgaggcc  ggccctcca  tgtccaccg  1200
aagtgcttc  gaggcggct  ccttacact  aggacgaca  tattgtgct  ggaatcctc  1260
gaggccctc  cccatctcc  atcagtcat  gtacagttt  tttacacac  tgcagtttg  1320
ttgtgcttc  aatatttat  gctttataa  taaaccaga  caggacttg  aacc  1374



<210> 10109
<211> 377
<212> PRT
<213> Rattus norvegicus
<308> CAA56429
<400> 10109

Met Cys Asp Asp Glu Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
  1               5                  10                  15
Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
             20                  25                  30
Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
         35                  40                  45
Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
     50                  55                  60
Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
 65                  70                  75                  80
Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                 85                  90                  95
Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
             100                105                110
Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
         115                120                125
Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
     130                135                140
Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
 145                150                155                160
Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                 165                170                175
Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
             180                185                190
Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
         195                200                205
Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
     210                215                220
Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
 225                230                235                240
Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                 245                250                255
Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
             260                265                270
Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
         275                280                285
Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
     290                295                300
Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
 305                310                315                320
Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                 325                330                335
Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
             340                345                350
Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
         355                360                365
Pro Ser Ile Val His Arg Lys Cys Phe 
     370                375



<210> 10110
<211> 1294
<212> DNA
<213> Homo sapiens
<308> NM_005159
<400> 10110

atgtgtgac  acgaggaga  caccgccct  gtgtgcgac  acggctctg  gctggtgaa  60
gccggcttt  cgggcgatg  cgcgccccg  gctgtcttc  cgtccatcg  gggccgccc  120
cggcaccag  gagttatgg  gggtatggg  cagaaggac  cctacgtag  tgatgaagc  180
cagagcaag  gaggcatcc  gaccctgaa  tatcccatc  agcatggta  catcaccaa  240
tgggacgac  tggagaaga  ctggcacca  accttctac  atgagctcc  tgttgctcc  300
gaggagcac  ccaccctgc  cacagaggc  ccgctgaac  ccaaggcca  ccgggagaa  360
atgactcag  tcatgtttg  gaccttcaa  gtccctgcc  tgtacgtgg  catccaggc  420
gtgctatcc  tgtatgctt  tggccgtac  acaggcatt  ttctggact  tggggatgg  480
gtaactcac  atgtcccca  ctatgaggg  tacgctttg  cccatgcca  catgcgtct  540
gatctggct  gtcgggacc  cactgacta  ctcatgaag  tcctcactg  gcgtggcta  600
tcctttgtc  ccactgctg  acgtgaaat  gtccgtgac  ttaaagaga  gctgtgcta  660
gtcgccctg  attttgaga  tgagatggc  acagctgcc  cttcctcct  cttggagaa  720
agctatgaa  tgcctgatg  ccaagtcat  actatcggc  atgagcgct  ccgctgtcc  780
gagacactc  tccagccct  cttcattgg  atggaatct  ctggcatcc  tgaaacaac  840
tacaatagc  tcatgaagt  tgacattga  atccgcaag  acctgtatg  caacaatgt  900
ttatctgga  gcaccacta  gtaccctgg  attgctgat  gtatgcaga  ggaaatcac  960
gctctggct  ctagcacca  gaagattaa  attattgct  cccctgagc  taaatactc  1020
gtctggatt  ggggctcca  cttggcctc  ctgtccacc  tccagcaaa  gtggattag  1080
aagcaagag  acgatgagg  aggcccatc  attgtccac  gcaaatgct  ctaagatgc  1140
ttctctctc  atctacctt  cagtcagga  gacggtatt  tgcttcttg  agtctccca  1200
accaccttc  ctcatcttt  atcaatcat  gtacagttt  tttacacac  tgcaatttg  1260
ttgtgcttc  aatatttat  gctttataa  taaa  1294



<210> 10111
<211> 377
<212> PRT
<213> Homo sapiens
<308> P04270
<400> 10111

Met Cys Asp Asp Glu Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
  1               5                  10                  15
Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
             20                  25                  30
Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
         35                  40                  45
Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
     50                  55                  60
Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
 65                  70                  75                  80
Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                 85                  90                  95
Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
             100                105                110
Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
         115                120                125
Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
     130                135                140
Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
 145                150                155                160
Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                 165                170                175
Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
             180                185                190
Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
         195                200                205
Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
     210                215                220
Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
 225                230                235                240
Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                 245                250                255
Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
             260                265                270
Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
         275                280                285
Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
     290                295                300
Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
 305                310                315                320
Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                 325                330                335
Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
             340                345                350
Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
         355                360                365
Pro Ser Ile Val His Arg Lys Cys Phe 
     370                375



<210> 10112
<211> 1593
<212> DNA
<213> Rattus norvegicus
<308> X80395
<400> 10112

atggaaccc  ccgcgccaa  cggtcaggc  cgggcggcg  ccaccaaac  gtcggaagc  60
gtgggagcc  cgctacaag  gccccagag  cagcggcgc  tggtgctgg  catcgtgtg  120
gttgcactg  tactggaca  catgttgta  atggtcatc  tgcccattg  tcccgacta  180
atcgcccac  tgcgcgggg  cagcgaggg  ccgaccctg  tctctgagg  gtgggaacc  240
actctgccg  cgcccactc  ggctaatgc  agtgcctac  tggccaaca  gtcggcgtc  300
ccgacggct  ccgggtcgg  tcggtcaat  ctgcgacct  gctacccca  agaaagcga  360
gatgtgaag  taggtgtgc  gtttgcctc  aaggctatc  tgcagcttc  ggtgaaccc  420
ttaagcggg  ctttcattg  tcgcatgag  tacgacgtg  cgctgctta  aggcctggg  480
gtcatgttc  cctccacag  catgtttgc  tttgcagaa  actatgcca  gctcttcgc  540
gcgcgcagt  tacaaggcc  gggctcggc  ttcgcggac  cgtctggca  tgccatgat  600
gccgacaag  atcccgagg  gcctgagcg  agtcgtgcc  tgggcgtgg  gctagcctt  660
attagcttt  gaagcctag  ggcgccacc  tttgggggc  tcctctacg  gttcgcggg  720
aagcgtgta  cctttctag  gctcgccgc  gtgtccctt  tcgacgcgc  cctgctcct  780
gcggtggct  agcccttct  ggctgcggc  cgggcgcga  ccaacctgc  ggtgggcac  840
cctatccat  gcctcatgc  agaccctta  atcgctgtg  tagccggcg  gctcaccac  900
tgtaacatt  cccttgcgt  cctcgagcc  accatagcc  cgtggatga  gcacacaat  960
gccgcatcc  agtgggaga  gggcatggt  tggctgccg  ctttcgtgc  acacgtgtt  1020
ggcgtctac  tcaccgtgc  cctggcggc  cgttatcca  acctgcagt  gctgtacgg  1080
gctctcggg  tagcggtaa  tggagtgag  tcttgcgtc  tacctgcct  tcgctcatt  1140
gcgccgtta  tggtctcgc  ctgcggact  tgcttcggc  tcgcgttag  ggacacagc  1200
ctcctaccc  cgctcgcct  tctggtgga  gtgcgccac  tatccgtct  tggcagtgt  1260
tatgccata  ctgacatct  ctattctgt  gcctacgcg  tcgggccca  agtggcagg  1320
cacatcgtt  actctcttg  ctttgagca  ctcagcctg  gcatgggcc  ggccaacct  1380
ctctacgca  cagtccttc  tcttttgcg  aatgtaggc  tccttacac  ctcgcgttc  1440
gagcgcgat  tgttgcttg  tgaaccgcc  cagggtctg  acgacgcgg  gcgcctgcg  1500
gaggtgcag  gcaaggatg  cggcgaacc  tgtagccca  ctggccctt  tgacgggtg  1560
gaggacgac  acaactatt  ctcccgcag  tag  1593



<210> 10113
<211> 530
<212> PRT
<213> Rattus norvegicus
<308> CAA56604
<400> 10113

Met Glu Pro Thr Ala Pro Thr Gly Gln Ala Arg Ala Ala Ala Thr Lys 
  1               5                  10                  15
Leu Ser Glu Ala Val Gly Ala Ala Leu Gln Glu Pro Gln Arg Gln Arg 
             20                  25                  30
Arg Leu Val Leu Val Ile Val Cys Val Ala Leu Leu Leu Asp Asn Met 
         35                  40                  45
Leu Tyr Met Val Ile Val Pro Ile Val Pro Asp Tyr Ile Ala His Met 
     50                  55                  60
Arg Gly Gly Ser Glu Gly Pro Thr Leu Val Ser Glu Val Trp Glu Pro 
 65                  70                  75                  80
Thr Leu Pro Pro Pro Thr Leu Ala Asn Ala Ser Thr Tyr Leu Ala Asn 
                 85                  90                  95
Thr Ser Ala Ser Pro Thr Ala Ala Gly Ser Ala Arg Ser Ile Leu Arg 
             100                105                110
Pro Arg Tyr Pro Thr Glu Ser Glu Asp Val Lys Ile Gly Val Leu Phe 
         115                120                125
Ala Ser Lys Ala Ile Leu Gln Leu Leu Val Asn Pro Leu Ser Gly Pro 
     130                135                140
Phe Ile Asp Arg Met Ser Tyr Asp Val Pro Leu Leu Ile Gly Leu Gly 
 145                150                155                160
Val Met Phe Ala Ser Thr Val Met Phe Ala Phe Ala Glu Asp Tyr Ala 
                 165                170                175
Thr Leu Phe Ala Ala Arg Ser Leu Gln Gly Leu Gly Ser Ala Phe Ala 
             180                185                190
Asp Thr Ser Gly Ile Ala Met Ile Ala Asp Lys Tyr Pro Glu Glu Pro 
         195                200                205
Glu Arg Ser Arg Ala Leu Gly Val Ala Leu Ala Phe Ile Ser Phe Gly 
     210                215                220
Ser Leu Val Ala Pro Pro Phe Gly Gly Ile Leu Tyr Glu Phe Ala Gly 
 225                230                235                240
Lys Arg Val Pro Phe Leu Val Leu Ala Ala Val Ser Leu Phe Asp Ala 
                 245                250                255
Leu Leu Leu Leu Ala Val Ala Lys Pro Phe Ser Ala Ala Ala Arg Ala 
             260                265                270
Arg Ala Asn Leu Pro Val Gly Thr Pro Ile His Arg Leu Met Leu Asp 
         275                280                285
Pro Tyr Ile Ala Val Val Ala Gly Ala Leu Thr Thr Cys Asn Ile Pro 
     290                295                300
Leu Ala Phe Leu Glu Pro Thr Ile Ala Thr Trp Met Lys His Thr Met 
 305                310                315                320
Ala Ala Ser Glu Trp Glu Met Gly Met Val Trp Leu Pro Ala Phe Val 
                 325                330                335
Pro His Val Leu Gly Val Tyr Leu Thr Val Arg Leu Ala Ala Arg Tyr 
             340                345                350
Pro His Leu Gln Trp Leu Tyr Gly Ala Leu Gly Leu Ala Val Ile Gly 
         355                360                365
Val Ser Ser Cys Val Val Pro Ala Cys Arg Ser Phe Ala Pro Leu Val 
     370                375                380
Val Ser Leu Cys Gly Leu Cys Phe Gly Ile Ala Leu Val Asp Thr Ala 
 385                390                395                400
Leu Leu Pro Thr Leu Ala Phe Leu Val Asp Val Arg His Val Ser Val 
                 405                410                415
Tyr Gly Ser Val Tyr Ala Ile Ala Asp Ile Ser Tyr Ser Val Ala Tyr 
             420                425                430
Ala Leu Gly Pro Ile Val Ala Gly His Ile Val His Ser Leu Gly Phe 
         435                440                445
Glu Gln Leu Ser Leu Gly Met Gly Leu Ala Asn Leu Leu Tyr Ala Pro 
     450                455                460
Val Leu Leu Leu Leu Arg Asn Val Gly Leu Leu Thr Arg Ser Arg Ser 
 465                470                475                480
Glu Arg Asp Val Leu Leu Asp Glu Pro Pro Gln Gly Leu Tyr Asp Ala 
                 485                490                495
Val Arg Leu Arg Glu Val Gln Gly Lys Asp Gly Gly Glu Pro Cys Ser 
             500                505                510
Pro Pro Gly Pro Phe Asp Gly Cys Glu Asp Asp Tyr Asn Tyr Tyr Ser 
         515                520                525
Arg Ser 
     530



<210> 10114
<211> 2421
<212> DNA
<213> Homo sapiens
<308> NM_003055
<400> 10114

ggaggaggc  agagccgac  cgaggggag  ggagcgcag  ggcggggct  acgggcggg  60
aagcgggcg  gcggcaaca  catgtccct  ggccagcgc  ggcggcctc  tagcgcggc  120
ggggctgct  tgggcgcgc  ccgggcgaa  tgcgcccag  ctccggccc  ggcccctcg  180
cgcgcccga  ttcccggcc  cccctgagc  cagcagccg  gggtcccgg  atcggctaa  240
agtagctgc  acgcctcgc  ggacggagt  ctttccttt  ccgggacgc  gggccatga  300
ctccgcggc  cacctgagg  acaggggag  ctgctcggc  aggacagcc  ccccgaagt  360
ccgctgccc  cgcctctgc  ctgcgggac  ccagcgctc  gccctggcg  aggcgtctt  420
ggaagagca  cggggtggg  gcatggaat  cgcggaacc  gcgggccag  cccgggcgg  480
ggccaccaa  ctgtcggag  ctgtgggcg  ggcgctgca  gagccccgg  ggcagaggc  540
cctggtgct  gttatcgtg  gcgtggcgc  gttactgga  aacatgctg  acatggtca  600
cgtgcccat  gtgcccgac  acatcgccc  catgcgcgg  ggcggcgag  gccccaccc  660
gactcccga  gtgtgggag  ccaccctgc  gctgcccac  ccggccaat  ccagcgcct  720
cacggccaa  acctcggcg  ccccgacag  tgcgtggcc  gcgggctca  cccttcggc  780
ccgctaccc  acggagagc  aagacgtga  gatcggggt  ctgtttgct  ccaaggcta  840
cctgcagct  ctagtgaac  ccttgagcg  gcccttcat  gaccgcatg  gctacgacg  900
gccgctgct  atcggcctg  gcgtcatgt  cgcctctac  gtcctgttc  ccttcgccg  960
ggactacgc  acgctgttc  cggcgcgca  cctgcaggg  ctgggctca  ccttcgccg  1020
cacgtctgg  atagccatg  tcgccgata  gtacccgga  gagccggag  gcagtcgtg  1080
actgggcgt  gcgctggcc  tcattagct  cggaagcct  gtggccccg  ccttcgggg  1140
catcctcta  gagttcgcc  gcaagcgcg  gcccttctt  gtgctagct  ccgtgtcgc  1200
ctttgacgc  ctgttgctg  tggcagtgg  caaaccctt  tcggcggct  cacgggctc  1260
ggccaacct  ccagtgggc  ctcccatcc  ccgcctcat  ctagacccc  acattgccg  1320
ggtggccgg  gcgctcacc  cctgtaaca  tcccctcgc  ttcctcgaa  ccaccattg  1380
cacgtggat  aagcatacg  tggcggctt  cgagtggga  atgggcatg  cctggctgc  1440
ggccttcgt  cctcatgtg  tgggcgtct  cctcaccgt  cgcctggcg  cgcgctacc  1500
acacctgca  tggctgtac  gcgcgcttg  gctggctgt  atcggcgcc  gctcgtgca  1560
cgtgcccgc  tgccgctcc  tcgcgccgc  agtggtctc  ctatgcggc  tctgttttg  1620
catagccct  gtcgacaca  cactgctgc  cacgctcgc  ttcctggtg  acgtgcgcc  1680
tgtctcagt  tatggcagc  tctacgcca  cgccgacat  tcctattcg  tggcctacg  1740
gctcgggcc  atagtggca  gccacattg  gcactcgct  ggctttgag  agctcagcc  1800
tggcatggg  ctggccaac  tgctctatg  tcccgtctt  ctgctgctc  gcaacgtgg  1860
cctcctgac  cgctcccgt  ccgagcgcg  tgtgctgct  gatgagcca  cgcaaggtc  1920
gtacgatgc  gtgcgcctg  gtgagcgtc  tgtgtctgg  caggacggc  agcctcgca  1980
cccgcctgg  ccttttgat  agtgcgagg  cgactacaa  tactactac  cccgcagct  2040
gcatcccca  tcctcctcc  gcccaccca  ccgccttgg  tcaaggggg  tgctctgca  2100
gcccactgg  cagctctgg  tcagggccc  cctcctcca  cgagtaccc  agccactcc  2160
caaccttga  ttctgccca  atcccctcc  tgtgacccg  tccatatcc  tttctctct  2220
gtccaatgg  gcttggagc  ccgaggcca  cgaagccat  gcgctcctt  cggaggtga  2280
gaggaccct  agtccccac  tgcggctcc  ctgtgtaga  cctgcatct  tctgtcctt  2340
cttccattg  tcccagtgc  aaacttggg  cgctgcacc  cggcgcctc  gcccaaatc  2400
ataaactgt  tctgtccca  g  2421



<210> 10115
<211> 532
<212> PRT
<213> Homo sapiens
<308> NP_003046
<400> 10115

Met Glu Ser Ala Glu Pro Ala Gly Gln Ala Arg Ala Ala Ala Thr Lys 
  1               5                  10                  15
Leu Ser Glu Ala Val Gly Ala Ala Leu Gln Glu Pro Arg Arg Gln Arg 
             20                  25                  30
Arg Leu Val Leu Val Ile Val Cys Val Ala Leu Leu Leu Asp Asn Met 
         35                  40                  45
Leu Tyr Met Val Ile Val Pro Ile Val Pro Asp Tyr Ile Ala His Met 
     50                  55                  60
Arg Gly Gly Gly Glu Gly Pro Thr Arg Thr Pro Glu Val Trp Glu Pro 
 65                  70                  75                  80
Thr Leu Pro Leu Pro Thr Pro Ala Asn Ala Ser Ala Tyr Thr Ala Asn 
                 85                  90                  95
Thr Ser Ala Ser Pro Thr Ala Ala Trp Pro Ala Gly Ser Ala Leu Arg 
             100                105                110
Pro Arg Tyr Pro Thr Glu Ser Glu Asp Val Lys Ile Gly Val Leu Phe 
         115                120                125
Ala Ser Lys Ala Ile Leu Gln Leu Leu Val Asn Pro Leu Ser Gly Pro 
     130                135                140
Phe Ile Asp Arg Met Ser Tyr Asp Val Pro Leu Leu Ile Gly Leu Gly 
 145                150                155                160
Val Met Phe Ala Ser Thr Val Leu Phe Ala Phe Ala Glu Asp Tyr Ala 
                 165                170                175
Thr Leu Phe Ala Ala Arg Ser Leu Gln Gly Leu Gly Ser Ala Phe Ala 
             180                185                190
Asp Thr Ser Gly Ile Ala Met Ile Ala Asp Lys Tyr Pro Glu Glu Pro 
         195                200                205
Glu Arg Ser Arg Ala Leu Gly Val Ala Leu Ala Phe Ile Ser Phe Gly 
     210                215                220
Ser Leu Val Ala Pro Pro Phe Gly Gly Ile Leu Tyr Glu Phe Ala Gly 
 225                230                235                240
Lys Arg Val Pro Phe Leu Val Leu Ala Ala Val Ser Leu Phe Asp Ala 
                 245                250                255
Leu Leu Leu Leu Ala Val Ala Lys Pro Phe Ser Ala Ala Ala Arg Ala 
             260                265                270
Arg Ala Asn Leu Pro Val Gly Thr Pro Ile His Arg Leu Met Leu Asp 
         275                280                285
Pro Tyr Ile Ala Val Val Ala Gly Ala Leu Thr Thr Cys Asn Ile Pro 
     290                295                300
Leu Ala Phe Leu Glu Pro Thr Ile Ala Thr Trp Met Lys His Thr Met 
 305                310                315                320
Ala Ala Ser Glu Trp Glu Met Gly Met Ala Trp Leu Pro Ala Phe Val 
                 325                330                335
Pro His Val Leu Gly Val Tyr Leu Thr Val Arg Leu Ala Ala Arg Tyr 
             340                345                350
Pro His Leu Gln Trp Leu Tyr Gly Ala Leu Gly Leu Ala Val Ile Gly 
         355                360                365
Ala Ser Ser Cys Ile Val Pro Ala Cys Arg Ser Phe Ala Pro Leu Val 
     370                375                380
Val Ser Leu Cys Gly Leu Cys Phe Gly Ile Ala Leu Val Asp Thr Ala 
 385                390                395                400
Leu Leu Pro Thr Leu Ala Phe Leu Val Asp Val Arg His Val Ser Val 
                 405                410                415
Tyr Gly Ser Val Tyr Ala Ile Ala Asp Ile Ser Tyr Ser Val Ala Tyr 
             420                425                430
Ala Leu Gly Pro Ile Val Ala Gly His Ile Val His Ser Leu Gly Phe 
         435                440                445
Glu Gln Leu Ser Leu Gly Met Gly Leu Ala Asn Leu Leu Tyr Ala Pro 
     450                455                460
Val Leu Leu Leu Leu Arg Asn Val Gly Leu Leu Thr Arg Ser Arg Ser 
 465                470                475                480
Glu Arg Asp Val Leu Leu Asp Glu Pro Pro Gln Gly Leu Tyr Asp Ala 
                 485                490                495
Val Arg Leu Arg Glu Arg Pro Val Ser Gly Gln Asp Gly Glu Pro Arg 
             500                505                510
Ser Pro Pro Gly Pro Phe Asp Glu Cys Glu Asp Asp Tyr Asn Tyr Tyr 
         515                520                525
Tyr Thr Arg Ser 
     530



<210> 10116
<211> 1694
<212> DNA
<213> Rattus norvegicus
<308> X82021
<400> 10116

gcgtcgacg  gcttggcat  gggcctccg  agccgccca  cgccagaag  ttccagcct  60
accactatg  atccccgca  agtgagcga  cttcgggcc  tcgtgaaga  gtgtaggca  120
gacccgagc  tcctgcaca  cgaggaaat  cgtttcctg  gggagtggg  ggagagcat  180
gggggtaaa  taccacctg  tactcataa  gcgaagtca  aagaaaaca  taaggaaga  240
aaaagagac  agacgacag  ggacaacat  aagacagag  agccatcga  tgaggagag  300
gatctagaa  ttgacaatg  aggtgtaat  gaagcagac  ctgatgctc  tcaggaaat  360
ggagatgaa  atgcagaga  aactgaggc  atgatggat  aagcaaatg  aaagaaggg  420
gctgccatc  acgctctaa  tgatggtga  ctccagaaa  ccattgact  gttcacaga  480
gccatcaag  taaaccctc  cttggccat  ctgtatgcc  agagagcca  tgttttcgt  540
aaattacag  agccaaatg  tgccatccg  gactgtgac  gagctattg  aataaaccc  600
gattcagct  agccataca  atggagagg  aaagcgcac  gactcctgg  tcactggga  660
gaagcagct  gcgatcttg  cctggcctg  aaattggac  atgatgagg  cgccagtgc  720
atgctgaga  aagtccagc  tcgggctca  aaaattgct  aacatcgga  aaagtatga  780
cgaaaacgt  aagagcgag  gataaaaga  cgaatagaa  gggtgaaga  ggctcgaga  840
gagcatgaa  aagcccaaa  ggaagaaga  gccagaaga  aatctggat  tcagtttgg  900
tcttttcca  gtggttttc  tgggggaat  cctggtaat  ttcctggag  aatgcctgg  960
atgggaggg  ccatgccag  aatggcagg  atgcctgga  tcaacgaaa  cctcagtga  1020
ccagaggtt  ttgcagcca  gcaggatcc  gaagtcatg  tggctttcc  ggatgtggc  1080
cagaaccca  caaatatgt  aaaatatca  aacaaccca  aggttatga  tctcatcag  1140
aaattgtca  ccaagtttg  aggtcactc  taatgtcaa  gcccttgct  aatgaagaa  1200
agcttagct  acttactgg  tgttgcaat  atacaaacc  gtgtacctc  gacctcacc  1260
gagagctgg  gcgcttcga  gataatccc  accctctgc  tcatatgcg  ctgaggcat  1320
ttacagtgg  ttgccatta  agtgttcat  cagataatg  tttcctatt  ggaattaca  1380
acttaaaac  tttttcaac  ttaaacata  tttttaaaa  tttagggga  gtcaattcc  1440
acatttttc  ttactaatc  ttttgggtt  ttccttttg  attactggg  aaggaaggt  1500
aatgtggat  atttactgc  ttcatgaat  aaataaaga  ttgttagtg  gaagcaaat  1560
aaacacatt  aagttgatt  agtcggaca  acggttact  caacatctt  aattgtctt  1620
aatgtttta  ttcacaatg  tctatttca  taaatcttt  gggaccacc  aaaaaaaaa  1680
aaaaaaaaa  aaaa  1694



<210> 10117
<211> 368
<212> PRT
<213> Rattus norvegicus
<308> P50503
<400> 10117

Met Asp Pro Arg Lys Val Ser Glu Leu Arg Ala Phe Val Lys Met Cys 
  1               5                  10                  15
Arg Gln Asp Pro Ser Val Leu His Thr Glu Glu Met Arg Phe Leu Arg 
             20                  25                  30
Glu Trp Val Glu Ser Met Gly Gly Lys Val Pro Pro Ala Thr His Lys 
         35                  40                  45
Ala Lys Ser Glu Glu Asn Thr Lys Glu Glu Lys Arg Asp Lys Thr Thr 
     50                  55                  60
Glu Asp Asn Ile Lys Thr Glu Glu Pro Ser Ser Glu Glu Ser Asp Leu 
 65                  70                  75                  80
Glu Ile Asp Asn Glu Gly Val Ile Glu Ala Asp Thr Asp Ala Pro Gln 
                 85                  90                  95
Glu Met Gly Asp Glu Asn Ala Glu Ile Thr Glu Ala Met Met Asp Glu 
             100                105                110
Ala Asn Glu Lys Lys Gly Ala Ala Ile Asp Ala Leu Asn Asp Gly Glu 
         115                120                125
Leu Gln Lys Ala Ile Asp Leu Phe Thr Asp Ala Ile Lys Leu Asn Pro 
     130                135                140
Arg Leu Ala Ile Leu Tyr Ala Lys Arg Ala Ser Val Phe Val Lys Leu 
 145                150                155                160
Gln Lys Pro Asn Ala Ala Ile Arg Asp Cys Asp Arg Ala Ile Glu Ile 
                 165                170                175
Asn Pro Asp Ser Ala Gln Pro Tyr Lys Trp Arg Gly Lys Ala His Arg 
             180                185                190
Leu Leu Gly His Trp Glu Glu Ala Ala Arg Asp Leu Ala Leu Ala Cys 
         195                200                205
Lys Leu Asp Tyr Asp Glu Asp Ala Ser Ala Met Leu Arg Glu Val Gln 
     210                215                220
Pro Arg Ala Gln Lys Ile Ala Glu His Arg Arg Lys Tyr Glu Arg Lys 
 225                230                235                240
Arg Glu Glu Arg Glu Ile Lys Glu Arg Ile Glu Arg Val Lys Lys Ala 
                 245                250                255
Arg Glu Glu His Glu Lys Ala Gln Arg Glu Glu Glu Ala Arg Arg Gln 
             260                265                270
Ser Gly Ser Gln Phe Gly Ser Phe Pro Gly Gly Phe Pro Gly Gly Met 
         275                280                285
Pro Gly Asn Phe Pro Gly Gly Met Pro Gly Met Gly Gly Ala Met Pro 
     290                295                300
Gly Met Ala Gly Met Pro Gly Leu Asn Glu Ile Leu Ser Asp Pro Glu 
 305                310                315                320
Val Leu Ala Ala Met Gln Asp Pro Glu Val Met Val Ala Phe Gln Asp 
                 325                330                335
Val Ala Gln Asn Pro Ser Asn Met Ser Lys Tyr Gln Asn Asn Pro Lys 
             340                345                350
Val Met Asn Leu Ile Ser Lys Leu Ser Ala Lys Phe Gly Gly His Ser 
         355                360                365



<210> 10118
<211> 3145
<212> DNA
<213> Homo sapiens
<308> U17714
<400> 10118

gcggtcacg  cgagccagc  cctgggcct  gaaccgggc  gtagccccc  agtttcgcc  60
accacctcc  taccatgga  ccccgcaaa  tgaacgagc  tcgggcctt  gtgaaaatg  120
gtaagcagg  tccgagcgt  ctgcacacc  aggaaatgc  cttcctgag  gagtgggtg  180
agagcatgg  tggtaaagt  ccacctgct  ctcagaaag  taaatcaga  gaaaatacc  240
aggaagaaa  acctgatag  aagaaggtg  aggaagact  aaaggcaga  gaaccatca  300
gtgaggaaa  tgatctaga  attgataaa  aaggtgtga  tgaaccaga  actgatgct  360
ctcaagaaa  gggagatga  aatgcggag  taacggagg  gatgatgga  caggcaaat  420
ataaaaaag  ggctgctat  gaagcccta  atgatggtg  actccagaa  gccattgac  480
tattcacag  tgccatcaa  ctgaatcct  gcttggcca  tttgtatgc  aagagggcc  540
gtgtcttcg  caaattaca  aagccaaat  ctgccatcc  agactgtga  agagccatt  600
aaataaatc  tgattcagc  cagccttac  agtggcggg  gaaagcaca  agacttcta  660
gccactggg  agaagcagc  catgatctt  cccttgcct  taaattgga  tatgatgaa  720
atgctagtg  aatgctgaa  gaagttcaa  ctagggcac  gaaaattgc  gaacatcgg  780
gaaagtatg  gcgaaaacg  gaagagcga  agatcaaag  aagaataga  cgagttaag  840
aggctcgag  agagcatga  agagcccag  gggaggaag  agccagacg  cagtcagga  900
ctcagtatg  ctcttttcc  ggtggcttt  ctgggggaa  gcctggtaa  tttcccgga  960
gaatgcctg  aatgggagg  ggcatgcct  gaatggctg  aatgcctgg  ctcaatgaa  1020
ttcttagtg  tccagaggt  cttgcagcc  tgcaggatc  agaagttat  gtggctttc  1080
aggatgtgg  tcagaaccc  gcaaatatg  caaaatacc  gagcaaccc  aaggttatg  1140
atctcatca  taaattgtc  gccaaattt  gaggtcaag  gtaatgtcc  tctgataaa  1200
aaagccctt  ctgaaggaa  agcaaccta  atcacctta  ggatgtcgc  ataatacaa  1260
ccagtgtac  tctgacctt  tcatcaaga  agctggggt  ctttgaaga  aatccctac  1320
cctctcccc  aaatgcagc  gaagcattt  acagtggtt  gccattagg  tattcattc  1380
gataatgtt  tcctactag  aattacaaa  tttaaacac  ttttaaatc  tcaaaatat  1440
taaaacaaa  ttaaagggc  tgttaattc  tatattttt  tttactaat  attttggat  1500
tttttcttt  aattattgg  agggaatat  cttatgtat  gaagattac  gctctgagt  1560
aaataaaag  tattagtgc  aggcaaaca  aactcattt  aggataaag  ttgtgttgg  1620
tatgtggtt  ctgatgcat  ttgacttgt  tttttaaat  ctttatctt  ttctttaaa  1680
atttatttc  ataaaacta  ttgggacca  ccgtatttc  gtaggacct  ggtagggat  1740
ggaagtact  ggcagggca  cagcaatct  gctgtgttt  atataacat  catccttgg  1800
caggttgcc  ttaaatctt  cactgtggt  aagggatgt  ttttttgta  tgctgcagt  1860
gagttggag  acttagttc  cttgttgtc  agtatatct  ataagtgtt  ttcatatta  1920
ttccacgta  gggaaataa  gtagtactt  tctttttat  tttctatgc  taaaattct  1980
tttcctagt  aaaaattgc  caaatctgt  tttgctttc  gcttgctac  tttgtctcc  2040
ttacttttc  tgagctaaa  acaggcttt  tccaccggc  tcatcactg  tatcatcat  2100
aacagcgta  ttatacaag  atatttaat  ctgagttta  tttaatatg  aatacatat  2160
gtaattgta  ggtaatacc  acaacaact  tagtttctt  cttggccaa  agaatgctt  2220
tttaagtgt  agacttcca  tctggcaaa  tcttgcctt  tcagaagac  ttggaaaga  2280
ggattccct  tggtgtttg  tcttctact  agaaaaacc  attgcagtt  gtttatctt  2340
tagtattca  ctttgtatt  tgaagataa  gtttgaatt  aattgatac  cacagaggg  2400
aaccgattt  ttttatcca  tgtgaatta  aaatgagat  atccacagt  attcattgt  2460
gagttgttg  gactatgaa  gactcattg  ctttgtatt  agctcttaa  tagtgtaac  2520
atatcccca  ctctgcttg  tttctttcc  tcccctcca  tgataaaga  aatgataaa  2580
tttctgttg  gcattcaat  cttatttta  ataagacta  gtataggca  tgtacctga  2640
attgctacg  ttctaccag  gtttcaatt  aaagtgcta  tgtttaaaa  cattttcaa  2700
ggataaggc  ttctgtact  tgcttattt  aagaatcag  ggtaggagc  gtgaagtaa  2760
ttctatgga  tacatttct  aaataccac  tttctgaaa  cataaataa  tttattcag  2820
ttctaaccc  ttgctgtac  caagcagac  gaaatgcat  tgttacata  atgagaaaa  2880
gctattatg  tgatggagc  tgcttttta  atcctttaa  aacactcac  atataaact  2940
gcatttgag  ttgtgtgtt  ttttgttaa  gtgtagagt  ctcctttct  gaaattgcc  3000
gtgtgtact  ggcttaact  aagaacagt  tcttctgga  tccttattt  atttattta  3060
cctaattat  ttctaatat  gcaaatatt  ccataagtg  gtaaaagta  aattcctct  3120
ctgaaaaaa  aaaaaaaaa  aaaaa  3145



<210> 10119
<211> 369
<212> PRT
<213> Homo sapiens
<308> P50502
<400> 10119

Met Asp Pro Arg Lys Val Asn Glu Leu Arg Ala Phe Val Lys Met Cys 
  1               5                  10                  15
Lys Gln Asp Pro Ser Val Leu His Thr Glu Glu Met Arg Phe Leu Arg 
             20                  25                  30
Glu Trp Val Glu Ser Met Gly Gly Lys Val Pro Pro Ala Thr Gln Lys 
         35                  40                  45
Ala Lys Ser Glu Glu Asn Thr Lys Glu Glu Lys Pro Asp Ser Lys Lys 
     50                  55                  60
Val Glu Glu Asp Leu Lys Ala Asp Glu Pro Ser Ser Glu Glu Ser Asp 
 65                  70                  75                  80
Leu Glu Ile Asp Lys Glu Gly Val Ile Glu Pro Asp Thr Asp Ala Pro 
                 85                  90                  95
Gln Glu Met Gly Asp Glu Asn Ala Glu Ile Thr Glu Glu Met Met Asp 
             100                105                110
Gln Ala Asn Asp Lys Lys Val Ala Ala Ile Glu Ala Leu Asn Asp Gly 
         115                120                125
Glu Leu Gln Lys Ala Ile Asp Leu Phe Thr Asp Ala Ile Lys Leu Asn 
     130                135                140
Pro Arg Leu Ala Ile Leu Tyr Ala Lys Arg Ala Ser Val Phe Val Lys 
 145                150                155                160
Leu Gln Lys Pro Asn Ala Ala Ile Arg Asp Cys Asp Arg Ala Ile Glu 
                 165                170                175
Ile Asn Pro Asp Ser Ala Gln Pro Tyr Lys Trp Arg Gly Lys Ala His 
             180                185                190
Arg Leu Leu Gly His Trp Glu Glu Ala Ala His Asp Leu Ala Leu Ala 
         195                200                205
Cys Lys Leu Asp Tyr Asp Glu Asp Ala Ser Ala Met Leu Lys Glu Val 
     210                215                220
Gln Pro Arg Ala Gln Lys Ile Ala Glu His Arg Arg Lys Tyr Glu Arg 
 225                230                235                240
Lys Arg Glu Glu Arg Glu Ile Lys Glu Arg Ile Glu Arg Val Lys Lys 
                 245                250                255
Ala Arg Glu Glu His Glu Arg Ala Gln Arg Glu Glu Glu Ala Arg Arg 
             260                265                270
Gln Ser Gly Ala Gln Tyr Gly Ser Phe Pro Gly Gly Phe Pro Gly Gly 
         275                280                285
Met Pro Gly Asn Phe Pro Gly Gly Met Pro Gly Met Gly Gly Gly Met 
     290                295                300
Pro Gly Met Ala Gly Met Pro Gly Leu Asn Glu Ile Leu Ser Asp Pro 
 305                310                315                320
Glu Val Leu Ala Ala Met Gln Asp Pro Glu Val Met Val Ala Phe Gln 
                 325                330                335
Asp Val Ala Gln Asn Pro Ala Asn Met Ser Lys Tyr Gln Ser Asn Pro 
             340                345                350
Lys Val Met Asn Leu Ile Ser Lys Leu Ser Ala Lys Phe Gly Gly Gln 
         355                360                365
Ala 
     370



<210> 10120
<211> 3949
<212> DNA
<213> Rattus norvegicus
<308> X82669
<400> 10120

agtttcact  ctgctccta  cctgtgtca  gtccttctg  ccggacact  acgacacta  60
ggccattct  actcccatt  ggtgctgtg  accctgtga  ccaatcagc  tcgtcatgg  120
acaggagtt  taaagtccg  gcagcccgc  ggactcaga  tcgtccgga  tctcacatg  180
gggcgatgg  accgcgcac  ctgctcctg  tgctggcgg  cgccctggc  cagacccag  240
cccgcgcgg  tgagtgcgg  gtcgggagg  aaacggcct  tgcggggag  cgcgggggc  300
gttttgggg  agccgggtc  ccgcgtcgc  caccagacc  ccgcccctt  tccacccgc  360
tcccgagcc  cgcgccctg  tccccgccc  gcccgcgct  ccgcccggg  tcccgggag  420
aggtcgggg  ctcaccgcg  gccgccccc  ggctcacac  cgctgcggt  tttcctcac  480
gccgtgtcc  ggcccggcc  cggggagcc  cggttcatc  ctgtcggct  cgtggacga  540
acggagttc  tgcgctacg  cagcgatgc  gagaatccg  ggatggagc  gcgggcgcg  600
tggatggag  gggaggggc  ggagtattg  gagcgggag  cgcagggag  caagggaca  660
gagcaggtg  accgagtga  cctgaggac  ctgcgcggc  actacaacc  gagcgaggg  720
ggtgagtga  cccgggtcg  aggtcacga  ccctccgcg  ccccacacg  ccggggact  780
ccgggtccc  agtccgagg  tcgggagca  aaccgaccc  ggcccggtt  ccctttcag  840
ttggaggag  ccgcgggcg  ggcggggct  gggcggggt  tgaccgcgg  gtcctgcag  900
ctctcacac  atccaggtg  tgtttggct  tgacgtggg  acggactgg  gcctcctcc  960
cggatatag  caggacgcc  acgacggcc  cgattacat  gccctgaac  aagacctga  1020
gacgtggac  gcggcggac  ttgctgcac  gatcacccg  aacaagttg  agcgggatg  1080
tgatgcaga  tattacaag  cctacctgg  gggcacgtg  ttggagtcg  tccgcagat  1140
cctggagct  gggaaggag  ggctgctgc  ctcaggtac  tggaccgcg  gcttctcct  1200
ctctgccct  aggctgggg  tcagtcctg  ggaagaaga  accctcagc  gggtgatgc  1260
cctgtctca  aggggagac  gcgtccctg  gtctcctga  ccctcatca  agtgactgc  1320
ctgcctctc  cagggccca  ccttctccc  ggagagttc  gagtccctc  caggagggc  1380
aggagagaa  ttcccactt  acagcaagg  ctccctgct  tcagccatg  cctctccca  1440
gccaggttc  ctgctccga  tctctgagg  cactgactc  tgtcctgct  agtgtgtca  1500
cgttacacc  caggaccag  agtctcctt  acctcatgg  agacatgga  tccactaca  1560
taggctggt  ccccagttt  tagaacttt  caaagaaca  attctcaca  atccctccc  1620
gatgtgggg  ttgcctctc  tccacaccc  aattctctc  cttcctaca  tggagaatg  1680
tcccatgag  ccttgtggg  taccctgaa  gaacataaa  tgtgggatt  cttttttct  1740
ttttctctc  ttttcttat  ttttacttt  ttttttctt  ccttttctt  ccctttttt  1800
ttttgaagg  ttattttgc  tccagtcaa  atttctctg  aaacacata  taaatcaat  1860
attttccat  ccctcttta  tctgtgacc  cccatctca  gctataaaa  atcacataa  1920
gacggccat  ttgacccac  cgaatcatg  ggatttcct  ttagcttct  agtccctca  1980
gaaagtgtg  agttctgtg  tgagggcac  agctctccc  gcagctcac  agtgagatg  2040
cagttgaag  gtcagacac  cacagttca  tgtcatcat  gatttaact  tgtcttgtg  2100
agatttcag  ttgtcttgt  aactgtgtg  tttcttaaa  cttccacac  gatccccca  2160
aggcacatg  gacccttca  cccagacct  aaggtgatg  caccctgag  tgctgggcc  2220
tgggcttct  ccctgctga  atcaccctg  cctggcagt  gaatgggga  gacctgacc  2280
aggacatgg  gcttgtgga  accaggcct  caggggatg  aaccttcca  aagtgggca  2340
ctgtggtgg  gcctcttgg  aaggagcag  attacacat  ccttgtgga  catgagggg  2400
tgcctgagc  actttccca  agatggggt  aggagggag  cttctgtag  ccctgagct  2460
gtcagggct  agagctggg  tcatgaccc  caccttcat  tcttgaacc  gtccttccc  2520
gagccttct  catcgacca  ctccaacat  gaaaccaat  tcatttatg  cgcccttgg  2580
gccatcatt  gaactctgg  catcattgg  attgtggtg  ctgttgtga  gaagaggag  2640
agaaacaca  gtaggaaag  acagggtct  tttcccctc  gcttccttt  gaagagtgc  2700
gctcattaa  gggaagcac  gccacaccc  ctattgctg  tgctccaac  gggtcctct  2760
tcagttctg  aaacttcct  ctgtcaaga  cttccttga  ctctcacag  ttttcttct  2820
acaggtggg  aaggagact  cgcccctgc  ccaggttag  gtgggcgca  gagtgtccc  2880
gagggtatt  gagtgaagc  ggagatgtg  ggagctctg  gaatccata  tagctcctc  2940
aaatcttct  gggctgcag  tgtactgtg  gtgatatga  tacatacat  cgcatatac  3000
tatacacac  cacatatac  tgtgttttg  tttacccta  gcagggaca  ctcccagag  3060
tctgatgtg  ctctcccag  ttgtaaagg  gactctggg  tttgactgg  aagggacaa  3120
gtggacatg  ttgggttca  ggactccca  aatcctctg  ttcatggac  cccagaatc  3180
tctgggagt  ttgtcttca  agtgatggt  tgtgactct  gttctgtag  atgaagaca  3240
ctgcctgga  tggactgag  gacagacga  gtgttcagg  ctctcctgt  acatccaga  3300
tcctcagtt  tctttagac  ccagtgtct  atgttccct  tgattctat  gcttcagtg  3360
gaagaactg  ggagcccag  ctgccctgc  cacctggac  ctgtccctg  acctgccct  3420
cattccttt  cacctgcca  ccttgctgg  ccagcctgg  gtaggggta  tgggacacg  3480
acctgtcac  ccttgctgc  ctgagcctt  agcccctca  tccacactg  gaataagac  3540
ctgagtgtg  acttgattg  tcacatcct  gacccaagt  tggatggct  tttaattac  3600
ggattgaga  tacttagag  ttttttgtt  tggggtttt  ctttgtttt  ttttgtttt  3660
gaaaaaaat  aatggcaga  gaagaagct  ccagaatct  tgtcactaa  ctgtgtgtg  3720
ctggtggga  agggtgagg  ggtgggagc  gagtgtgga  agggctgtg  ccaggtgtg  3780
tcagtcagt  cttgtcttt  atgggttca  gcctcagct  tgtcacctc  aggctgtgc  3840
ctctccatc  ctgtgaaca  atggggaga  tctgtgatc  cgatgacac  gggaaggcc  3900
gagccttgt  ctgtcccca  gattatgag  ccccgcggc  gaagatcac  3949



<210> 10121
<211> 319
<212> PRT
<213> Rattus norvegicus
<308> P15978
<400> 10121

Met Gly Ala Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Val 
  1               5                  10                  15
Leu Ala Pro Thr Gln Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe 
             20                  25                  30
His Thr Ala Val Ser Arg Pro Gly Leu Gly Glu Pro Arg Phe Ile Ser 
         35                  40                  45
Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Tyr Asp Ser Asp Ala 
     50                  55                  60
Glu Asn Pro Arg Tyr Glu Pro Arg Ala Arg Trp Met Glu Arg Glu Gly 
 65                  70                  75                  80
Pro Glu Tyr Trp Glu Glu Gln Thr Leu Val Ala Lys Gly Gln Glu Leu 
                 85                  90                  95
Asp Tyr Arg Val Ser Leu Arg Asn Leu Leu Ser Tyr Tyr Asn Gln Ser 
             100                105                110
Glu Gly Gly Ser His Thr Ile Gln Arg Met Tyr Gly Cys Asp Val Gly 
         115                120                125
Ser Asp Gly Ser Leu Leu Arg Gly Tyr Glu Gln His Ala Tyr Asp Gly 
     130                135                140
Arg Asp Tyr Ile Ala Leu Asn Glu Asp Leu Lys Thr Trp Ala Val Ala 
 145                150                155                160
Asp Phe Ala Ala Trp Ile Thr Arg Ser Lys Trp Gln Arg Asn Gly Ala 
                 165                170                175
Ala Glu Arg Ser Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
             180                185                190
Leu Arg Tyr Leu Glu Arg Gly Lys Glu Thr Leu Leu Arg Ser Asp Pro 
         195                200                205
Pro Glu Ala His Val Thr Leu His Pro Arg Pro Glu Gly Asp Val Thr 
     210                215                220
Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr 
 225                230                235                240
Trp Gln Leu Asn Gly Glu Asp Leu Thr Gln Asp Met Glu Leu Val Glu 
                 245                250                255
Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val 
             260                265                270
Val Pro Leu Gly Lys Glu Gln Asn Tyr Thr Cys Arg Val Glu His Glu 
         275                280                285
Gly Leu Pro Glu Pro Leu Ser Gln Arg Trp Glu Pro Ser Pro Ser Thr 
     290                295                300
Asp Ser Asn Leu Leu Leu Leu Phe Leu Glu Leu Trp Gln Phe Leu 
 305                310                315



<210> 10122
<211> 1089
<212> DNA
<213> Homo sapiens
<308> L36318
<400> 10122

atgctggtc  tggcgcccc  aaccgtcct  ctgctgctc  cggcggccc  ggccctgac  60
gagacctgg  ccggctccc  ctccatgag  tatttctac  cctccgtgt  ccggcccgg  120
cgcggggag  cccgcttca  ctcagtggg  tacgtggac  acacgcagt  cgtgaggtt  180
gacagcgac  ccgcgagtc  gagagagga  ccgcgggcg  cgtggatag  gcaggaggg  240
ccggaatat  gggaccgga  cacacagat  tgcaagacc  acacacaga  ttaccgaga  300
agcctgcgg  acctgcgcg  ctactacaa  cagagcgag  ccgggtctc  caccctcca  360
aggatgtac  gctgcgacg  ggggccgga  gggcgcctc  tccgcgggc  taaccagtt  420
gcctacgac  gcaaggatt  catcgccct  aacgaggac  tgagctcct  gaccgcggc  480
gacaccgcg  ctcagatca  ccagcgcaa  tgggaggcg  cccgtgtgg  ggagcagct  540
agaacctac  tggagggca  gtgcgtgga  tggctccgc  gatacctgg  gaacgggaa  600
gagacgctg  agcgcgcgg  ccccccaaa  acacatgtg  cccaccacc  catctctga  660
catgaggcc  ccctgaggt  ctgggccct  ggcttctac  ctgcggaga  cacactgac  720
tggcagcgg  atggcgagg  ccaaactca  gacaccgag  ttgtggaga  cagaccagc  780
ggagacaga  ccttccaga  gtgggcagc  gtggtggtg  cttctggag  agagcagag  840
tacacatgc  atgtacagc  tgaggggct  ccgaagccc  tcaccctga  atgggagcc  900
tcttcccag  ccaccgtcc  catcgtggg  attgttgct  gcctggctg  cctagcagt  960
gtggtcatc  gagctgtgg  cgctgctgt  atgtgtagg  ggaagagtt  aggtggaaa  1020
ggagggagc  actctcagg  tgcgtccag  gacagtgcc  agggctctg  tgtgtctct  1080
acagcttga  1089



<210> 10123
<211> 362
<212> PRT
<213> Homo sapiens
<308> P30474
<400> 10123

Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Trp Gly Ala 
  1               5                  10                  15
Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
             20                  25                  30
Tyr Thr Ala Met Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
         35                  40                  45
Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
     50                  55                  60
Ala Ser Pro Arg Thr Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
 65                  70                  75                  80
Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Phe Lys Thr Asn Thr Gln 
                 85                  90                  95
Thr Tyr Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
             100                105                110
Glu Ala Gly Ser His Ile Ile Gln Arg Met Tyr Gly Cys Asp Leu Gly 
         115                120                125
Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Ser Ala Tyr Asp Gly 
     130                135                140
Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
 145                150                155                160
Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                 165                170                175
Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Leu Cys Val Glu Trp Leu 
             180                185                190
Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
         195                200                205
Pro Lys Thr His Val Thr His His Pro Val Ser Asp His Glu Ala Thr 
     210                215                220
Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
 225                230                235                240
Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                 245                250                255
Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
             260                265                270
Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
         275                280                285
Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
     290                295                300
Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
 305                310                315                320
Val Val Ile Gly Ala Val Val Ala Thr Val Met Cys Arg Arg Lys Ser 
                 325                330                335
Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
             340                345                350
Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
         355                360



<210> 10124
<211> 3949
<212> DNA
<213> Rattus norvegicus
<308> X82669
<400> 10124

agtttcact  ctgctccta  cctgtgtca  gtccttctg  ccggacact  acgacacta  60
ggccattct  actcccatt  ggtgctgtg  accctgtga  ccaatcagc  tcgtcatgg  120
acaggagtt  taaagtccg  gcagcccgc  ggactcaga  tcgtccgga  tctcacatg  180
gggcgatgg  accgcgcac  ctgctcctg  tgctggcgg  cgccctggc  cagacccag  240
cccgcgcgg  tgagtgcgg  gtcgggagg  aaacggcct  tgcggggag  cgcgggggc  300
gttttgggg  agccgggtc  ccgcgtcgc  caccagacc  ccgcccctt  tccacccgc  360
tcccgagcc  cgcgccctg  tccccgccc  gcccgcgct  ccgcccggg  tcccgggag  420
aggtcgggg  ctcaccgcg  gccgccccc  ggctcacac  cgctgcggt  tttcctcac  480
gccgtgtcc  ggcccggcc  cggggagcc  cggttcatc  ctgtcggct  cgtggacga  540
acggagttc  tgcgctacg  cagcgatgc  gagaatccg  ggatggagc  gcgggcgcg  600
tggatggag  gggaggggc  ggagtattg  gagcgggag  cgcagggag  caagggaca  660
gagcaggtg  accgagtga  cctgaggac  ctgcgcggc  actacaacc  gagcgaggg  720
ggtgagtga  cccgggtcg  aggtcacga  ccctccgcg  ccccacacg  ccggggact  780
ccgggtccc  agtccgagg  tcgggagca  aaccgaccc  ggcccggtt  ccctttcag  840
ttggaggag  ccgcgggcg  ggcggggct  gggcggggt  tgaccgcgg  gtcctgcag  900
ctctcacac  atccaggtg  tgtttggct  tgacgtggg  acggactgg  gcctcctcc  960
cggatatag  caggacgcc  acgacggcc  cgattacat  gccctgaac  aagacctga  1020
gacgtggac  gcggcggac  ttgctgcac  gatcacccg  aacaagttg  agcgggatg  1080
tgatgcaga  tattacaag  cctacctgg  gggcacgtg  ttggagtcg  tccgcagat  1140
cctggagct  gggaaggag  ggctgctgc  ctcaggtac  tggaccgcg  gcttctcct  1200
ctctgccct  aggctgggg  tcagtcctg  ggaagaaga  accctcagc  gggtgatgc  1260
cctgtctca  aggggagac  gcgtccctg  gtctcctga  ccctcatca  agtgactgc  1320
ctgcctctc  cagggccca  ccttctccc  ggagagttc  gagtccctc  caggagggc  1380
aggagagaa  ttcccactt  acagcaagg  ctccctgct  tcagccatg  cctctccca  1440
gccaggttc  ctgctccga  tctctgagg  cactgactc  tgtcctgct  agtgtgtca  1500
cgttacacc  caggaccag  agtctcctt  acctcatgg  agacatgga  tccactaca  1560
taggctggt  ccccagttt  tagaacttt  caaagaaca  attctcaca  atccctccc  1620
gatgtgggg  ttgcctctc  tccacaccc  aattctctc  cttcctaca  tggagaatg  1680
tcccatgag  ccttgtggg  taccctgaa  gaacataaa  tgtgggatt  cttttttct  1740
ttttctctc  ttttcttat  ttttacttt  ttttttctt  ccttttctt  ccctttttt  1800
ttttgaagg  ttattttgc  tccagtcaa  atttctctg  aaacacata  taaatcaat  1860
attttccat  ccctcttta  tctgtgacc  cccatctca  gctataaaa  atcacataa  1920
gacggccat  ttgacccac  cgaatcatg  ggatttcct  ttagcttct  agtccctca  1980
gaaagtgtg  agttctgtg  tgagggcac  agctctccc  gcagctcac  agtgagatg  2040
cagttgaag  gtcagacac  cacagttca  tgtcatcat  gatttaact  tgtcttgtg  2100
agatttcag  ttgtcttgt  aactgtgtg  tttcttaaa  cttccacac  gatccccca  2160
aggcacatg  gacccttca  cccagacct  aaggtgatg  caccctgag  tgctgggcc  2220
tgggcttct  ccctgctga  atcaccctg  cctggcagt  gaatgggga  gacctgacc  2280
aggacatgg  gcttgtgga  accaggcct  caggggatg  aaccttcca  aagtgggca  2340
ctgtggtgg  gcctcttgg  aaggagcag  attacacat  ccttgtgga  catgagggg  2400
tgcctgagc  actttccca  agatggggt  aggagggag  cttctgtag  ccctgagct  2460
gtcagggct  agagctggg  tcatgaccc  caccttcat  tcttgaacc  gtccttccc  2520
gagccttct  catcgacca  ctccaacat  gaaaccaat  tcatttatg  cgcccttgg  2580
gccatcatt  gaactctgg  catcattgg  attgtggtg  ctgttgtga  gaagaggag  2640
agaaacaca  gtaggaaag  acagggtct  tttcccctc  gcttccttt  gaagagtgc  2700
gctcattaa  gggaagcac  gccacaccc  ctattgctg  tgctccaac  gggtcctct  2760
tcagttctg  aaacttcct  ctgtcaaga  cttccttga  ctctcacag  ttttcttct  2820
acaggtggg  aaggagact  cgcccctgc  ccaggttag  gtgggcgca  gagtgtccc  2880
gagggtatt  gagtgaagc  ggagatgtg  ggagctctg  gaatccata  tagctcctc  2940
aaatcttct  gggctgcag  tgtactgtg  gtgatatga  tacatacat  cgcatatac  3000
tatacacac  cacatatac  tgtgttttg  tttacccta  gcagggaca  ctcccagag  3060
tctgatgtg  ctctcccag  ttgtaaagg  gactctggg  tttgactgg  aagggacaa  3120
gtggacatg  ttgggttca  ggactccca  aatcctctg  ttcatggac  cccagaatc  3180
tctgggagt  ttgtcttca  agtgatggt  tgtgactct  gttctgtag  atgaagaca  3240
ctgcctgga  tggactgag  gacagacga  gtgttcagg  ctctcctgt  acatccaga  3300
tcctcagtt  tctttagac  ccagtgtct  atgttccct  tgattctat  gcttcagtg  3360
gaagaactg  ggagcccag  ctgccctgc  cacctggac  ctgtccctg  acctgccct  3420
cattccttt  cacctgcca  ccttgctgg  ccagcctgg  gtaggggta  tgggacacg  3480
acctgtcac  ccttgctgc  ctgagcctt  agcccctca  tccacactg  gaataagac  3540
ctgagtgtg  acttgattg  tcacatcct  gacccaagt  tggatggct  tttaattac  3600
ggattgaga  tacttagag  ttttttgtt  tggggtttt  ctttgtttt  ttttgtttt  3660
gaaaaaaat  aatggcaga  gaagaagct  ccagaatct  tgtcactaa  ctgtgtgtg  3720
ctggtggga  agggtgagg  ggtgggagc  gagtgtgga  agggctgtg  ccaggtgtg  3780
tcagtcagt  cttgtcttt  atgggttca  gcctcagct  tgtcacctc  aggctgtgc  3840
ctctccatc  ctgtgaaca  atggggaga  tctgtgatc  cgatgacac  gggaaggcc  3900
gagccttgt  ctgtcccca  gattatgag  ccccgcggc  gaagatcac  3949



<210> 10125
<211> 319
<212> PRT
<213> Rattus norvegicus
<308> P15978
<400> 10125

Met Gly Ala Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Val 
  1               5                  10                  15
Leu Ala Pro Thr Gln Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe 
             20                  25                  30
His Thr Ala Val Ser Arg Pro Gly Leu Gly Glu Pro Arg Phe Ile Ser 
         35                  40                  45
Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Tyr Asp Ser Asp Ala 
     50                  55                  60
Glu Asn Pro Arg Tyr Glu Pro Arg Ala Arg Trp Met Glu Arg Glu Gly 
 65                  70                  75                  80
Pro Glu Tyr Trp Glu Glu Gln Thr Leu Val Ala Lys Gly Gln Glu Leu 
                 85                  90                  95
Asp Tyr Arg Val Ser Leu Arg Asn Leu Leu Ser Tyr Tyr Asn Gln Ser 
             100                105                110
Glu Gly Gly Ser His Thr Ile Gln Arg Met Tyr Gly Cys Asp Val Gly 
         115                120                125
Ser Asp Gly Ser Leu Leu Arg Gly Tyr Glu Gln His Ala Tyr Asp Gly 
     130                135                140
Arg Asp Tyr Ile Ala Leu Asn Glu Asp Leu Lys Thr Trp Ala Val Ala 
 145                150                155                160
Asp Phe Ala Ala Trp Ile Thr Arg Ser Lys Trp Gln Arg Asn Gly Ala 
                 165                170                175
Ala Glu Arg Ser Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
             180                185                190
Leu Arg Tyr Leu Glu Arg Gly Lys Glu Thr Leu Leu Arg Ser Asp Pro 
         195                200                205
Pro Glu Ala His Val Thr Leu His Pro Arg Pro Glu Gly Asp Val Thr 
     210                215                220
Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr 
 225                230                235                240
Trp Gln Leu Asn Gly Glu Asp Leu Thr Gln Asp Met Glu Leu Val Glu 
                 245                250                255
Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val 
             260                265                270
Val Pro Leu Gly Lys Glu Gln Asn Tyr Thr Cys Arg Val Glu His Glu 
         275                280                285
Gly Leu Pro Glu Pro Leu Ser Gln Arg Trp Glu Pro Ser Pro Ser Thr 
     290                295                300
Asp Ser Asn Leu Leu Leu Leu Phe Leu Glu Leu Trp Gln Phe Leu 
 305                310                315



<210> 10126
<211> 1089
<212> DNA
<213> Homo sapiens
<308> L36318
<400> 10126

atgctggtc  tggcgcccc  aaccgtcct  ctgctgctc  cggcggccc  ggccctgac  60
gagacctgg  ccggctccc  ctccatgag  tatttctac  cctccgtgt  ccggcccgg  120
cgcggggag  cccgcttca  ctcagtggg  tacgtggac  acacgcagt  cgtgaggtt  180
gacagcgac  ccgcgagtc  gagagagga  ccgcgggcg  cgtggatag  gcaggaggg  240
ccggaatat  gggaccgga  cacacagat  tgcaagacc  acacacaga  ttaccgaga  300
agcctgcgg  acctgcgcg  ctactacaa  cagagcgag  ccgggtctc  caccctcca  360
aggatgtac  gctgcgacg  ggggccgga  gggcgcctc  tccgcgggc  taaccagtt  420
gcctacgac  gcaaggatt  catcgccct  aacgaggac  tgagctcct  gaccgcggc  480
gacaccgcg  ctcagatca  ccagcgcaa  tgggaggcg  cccgtgtgg  ggagcagct  540
agaacctac  tggagggca  gtgcgtgga  tggctccgc  gatacctgg  gaacgggaa  600
gagacgctg  agcgcgcgg  ccccccaaa  acacatgtg  cccaccacc  catctctga  660
catgaggcc  ccctgaggt  ctgggccct  ggcttctac  ctgcggaga  cacactgac  720
tggcagcgg  atggcgagg  ccaaactca  gacaccgag  ttgtggaga  cagaccagc  780
ggagacaga  ccttccaga  gtgggcagc  gtggtggtg  cttctggag  agagcagag  840
tacacatgc  atgtacagc  tgaggggct  ccgaagccc  tcaccctga  atgggagcc  900
tcttcccag  ccaccgtcc  catcgtggg  attgttgct  gcctggctg  cctagcagt  960
gtggtcatc  gagctgtgg  cgctgctgt  atgtgtagg  ggaagagtt  aggtggaaa  1020
ggagggagc  actctcagg  tgcgtccag  gacagtgcc  agggctctg  tgtgtctct  1080
acagcttga  1089



<210> 10127
<211> 362
<212> PRT
<213> Homo sapiens
<308> P30474
<400> 10127

Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Trp Gly Ala 
  1               5                  10                  15
Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
             20                  25                  30
Tyr Thr Ala Met Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
         35                  40                  45
Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
     50                  55                  60
Ala Ser Pro Arg Thr Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
 65                  70                  75                  80
Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Phe Lys Thr Asn Thr Gln 
                 85                  90                  95
Thr Tyr Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
             100                105                110
Glu Ala Gly Ser His Ile Ile Gln Arg Met Tyr Gly Cys Asp Leu Gly 
         115                120                125
Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Ser Ala Tyr Asp Gly 
     130                135                140
Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
 145                150                155                160
Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                 165                170                175
Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Leu Cys Val Glu Trp Leu 
             180                185                190
Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
         195                200                205
Pro Lys Thr His Val Thr His His Pro Val Ser Asp His Glu Ala Thr 
     210                215                220
Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
 225                230                235                240
Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                 245                250                255
Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
             260                265                270
Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
         275                280                285
Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
     290                295                300
Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
 305                310                315                320
Val Val Ile Gly Ala Val Val Ala Thr Val Met Cys Arg Arg Lys Ser 
                 325                330                335
Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
             340                345                350
Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
         355                360



<210> 10128
<211> 2412
<212> DNA
<213> Rattus norvegicus
<308> X83537
<400> 10128

gagcaaaga  gcatttcca  gagcaattc  ctcacctcc  aggcgactg  gctctagga  60
tcacattcc  ttcctttag  agacaaagg  gcccaagag  gcagcggcg  gaccccagg  120
cgttggccc  gccgcggag  cctcactgc  cgacgcccc  acgccgggg  ccatgtctc  180
cgcccctcg  ccctcccgg  gtctcctgc  ccccctgct  acgctcggc  ccacgctcg  240
ctccctcgg  tgggcccaa  gcagcaact  cagccccga  gcttggctg  agcagtatg  300
ctacctacc  ccaggggac  tgcgtaccc  cacacaacg  tcaccccag  cactctcag  360
tgccattgc  gccatacaa  ggttctatg  tttacaagt  acaggcaag  ccgattcgg  420
cacgatgaa  gctatgagg  gccctcgct  tggtgttcc  gataagttt  ggactgaga  480
caaggccaa  gttcggagg  agcgctatg  cattcaggg  ctcaagtgg  agcataatg  540
gatcacttt  tgcatccag  attataccc  caaggtggg  gagtatgcc  cattcgagg  600
cattcggaa  gccttccga  tatgggaga  tgccacgcc  ctgcgcttc  gagaagtgc  660
ctatgccta  atccgggag  gtcatgaga  gcaggctga  atcatgatc  tgtttgctg  720
gggtttcca  ggcgacagc  caccctttg  tggtgaagg  ggcttcctg  ctcatgcct  780
tttcccagg  cccaatatc  gaggggata  ccactttga  tctgctgag  cctggactg  840
ccaaaatga  gatctaaat  ggaatgaca  cttcttggt  gctgtgcat  agttggggc  900
tgccctagg  ctggaacat  ccaacgacc  ctccgacat  atggctccc  tttaccagt  960
gatggacac  gagaacttc  tgttgcctg  tgacgatcg  cgcggtatc  agcaacttt  1020
tggaagcaa  tcagggtca  ccacaaaga  gccccctca  cccagaacc  cctctaggc  1080
ctctgtccc  gataagccc  gaaacccca  ctatgggcc  aacatctgt  atgggaact  1140
tgacaccgt  gccatgctc  gaggagaga  gtttgtctt  aaggagcga  ggttctggc  1200
ggtgaggaa  aaccaagtg  tggacggat  cccaatgcc  attggccaa  tctggaggg  1260
cctgcctgc  tccatcaac  ctgcctatg  gaggaagga  ggcaaattt  ttttcttca  1320
aggagataa  cactgggtg  ttgacgaag  ttccctgga  cccggatac  ccaagcaca  1380
taaggagct  ggccgagga  tgcccacgg  caagattga  gcagctctc  tctggatgc  1440
caacgggaa  acctacttc  tccggggaa  taagtacta  cgcttcaat  aggagttca  1500
ggcagtgga  agcgaatac  ccaaaaaca  caaagtctg  gaaggaatc  ctgagtctc  1560
cagaggctc  ttcatgggt  gcgatgaag  cttcacata  ttctacaaa  ggaacaaat  1620
ctggaaatt  aacaaccag  agctgaagg  agagccagg  taccccaag  cagctctgc  1680
ggactggat  ggctgccct  cggggggcc  gcccgacga  gggactgag  aggagacgg  1740
ggtgatcat  atcgaggtg  atgaggagg  cagcggagc  gtgagtgca  ctgctgtcg  1800
tctgccggt  ctgctgctg  tcctggtac  ggcagtggg  cttgctgtc  tcttcttta  1860
acgccatgg  acacccaag  gactgcttt  ctgccagcg  tcactgctg  acaaggtct  1920
acccccacc  ctggcccac  cgcttctac  acaaggact  tgcctcctc  gaagacagt  1980
gcagccggt  gtggcaggt  ggctgttct  acccatcct  ggctccctc  ctccagcct  2040
ccttctcag  ccctaattg  cttctccca  cctcatagc  tggtgtgtg  ccaacccta  2100
ttgaatgtt  tcaaggctc  gcacttgaa  gcaggaccc  ctgacctta  aggcaaagg  2160
caaatgggg  catctgctt  tcttccatc  ccctaacta  atatcttaa  tctctgaac  2220
atgacctca  gaggctttg  gcatatgag  cctatacgt  ccaagtgta  ccagttggc  2280
gcctcccgt  actctgact  aaaagaatc  tcagagtgc  tatttggag  tggaaagat  2340
gttcagtta  cctaaagac  ttgaaagaa  gaaagaaag  aagaaaaaa  aaaaaaaaa  2400
aaaaaaaaa  aa  2412



<210> 10129
<211> 582
<212> PRT
<213> Rattus norvegicus
<308> Q10739
<400> 10129

Met Ser Pro Ala Pro Arg Pro Ser Arg Ser Leu Leu Leu Pro Leu Leu 
  1               5                  10                  15
Thr Leu Gly Thr Thr Leu Ala Ser Leu Gly Trp Ala Gln Ser Ser Asn 
             20                  25                  30
Phe Ser Pro Glu Ala Trp Leu Gln Gln Tyr Gly Tyr Leu Pro Pro Gly 
         35                  40                  45
Asp Leu Arg Thr His Thr Gln Arg Ser Pro Gln Ser Leu Ser Ala Ala 
     50                  55                  60
Ile Ala Ala Ile Gln Arg Phe Tyr Gly Leu Gln Val Thr Gly Lys Ala 
 65                  70                  75                  80
Asp Ser Asp Thr Met Lys Ala Met Arg Arg Pro Arg Cys Gly Val Pro 
                 85                  90                  95
Asp Lys Phe Gly Thr Glu Ile Lys Ala Asn Val Arg Arg Lys Arg Tyr 
             100                105                110
Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys Ile 
         115                120                125
Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Phe Glu Ala Ile 
     130                135                140
Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe Arg 
 145                150                155                160
Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala Asp 
                 165                170                175
Ile Met Ile Leu Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro Phe 
             180                185                190
Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Asn 
         195                200                205
Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val Gln 
     210                215                220
Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His Glu 
 225                230                235                240
Leu Gly His Ala Leu Gly Leu Glu His Ser Asn Asp Pro Ser Asp Ile 
                 245                250                255
Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu Pro 
             260                265                270
Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Ser Lys Ser Gly 
         275                280                285
Ser Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro Ser 
     290                295                300
Val Pro Asp Lys Pro Arg Asn Pro Thr Tyr Gly Pro Asn Ile Cys Asp 
 305                310                315                320
Gly Asn Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe 
                 325                330                335
Lys Glu Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly 
             340                345                350
Tyr Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser Ile 
         355                360                365
Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys Gly 
     370                375                380
Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr Pro 
 385                390                395                400
Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile Asp 
                 405                410                415
Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg Gly 
             420                425                430
Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Phe Arg Ala Val Asp Ser Glu 
         435                440                445
Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro Arg 
     450                455                460
Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys Gly 
 465                470                475                480
Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro Gly 
                 485                490                495
Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Gly Gly 
             500                505                510
Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile Glu 
         515                520                525
Val Asp Glu Glu Gly Ser Gly Ala Val Ser Ala Ala Ala Val Val Leu 
     530                535                540
Pro Val Leu Leu Leu Leu Leu Val Leu Ala Val Gly Leu Ala Val Phe 
 545                550                555                560
Phe Phe Arg Arg His Gly Thr Pro Lys Arg Leu Leu Tyr Cys Gln Arg 
                 565                570                575
Ser Leu Leu Asp Lys Val 
             580



<210> 10130
<211> 2365
<212> DNA
<213> Homo sapiens
<308> X83535
<400> 10130

gaattcaag  tcagtgcct  ccgaagaca  aggcgcccc  agggagtgg  ggtgcgacc  60
cagggcgtg  gcccggccg  ggagcccac  ctgcccggc  gacccggtg  tctcggacc  120
tgtctcccg  cccaagacc  tcccgttgt  tcctgctcc  cctgctcac  ctcggcacc  180
cgctcgcct  cctcggctc  gcccaaagc  gcagcttca  ccccgaagc  tggctacag  240
aatatggct  cctgcctcc  ggggaccta  gtacccaca  acagcgctc  ccccagtca  300
tctcagcgg  catcgctgc  atgcagaag  tttacggct  gcaagtaac  ggcaaagct  360
atgcagaca  catgaaggc  atgaggcgc  cccgatgtg  tgttccaga  aagtttggg  420
ctgagatca  ggccaatgt  cgaaggaag  gctacgcca  ccagggtct  aaatggcaa  480
ataatgaaa  cactttctg  atccagaat  acaccccca  ggtgggcga  tatgccaca  540
acgaggcca  tcgcaaggc  ttccgcgtg  gggagagtg  cacaccact  cgcttccgc  600
aggtgccct  tgcctacat  cgtgagggc  atgagaagc  ggccgacat  atgatcttc  660
ttgccgagg  cttccatgg  gacagcacg  ccttcgatg  tgagggcgg  ttcctggcc  720
atgcctact  cccaggccc  aacattgga  gagacaccc  ctttgactc  gccgagcct  780
ggactgtca  gaatgagga  ctgaatgga  atgacatct  cctggtggc  gtgcacgag  840
tgggccatg  cctggggct  gagcattcc  gtgacccct  ggccatcat  gcacccttt  900
accagtgga  ggacacgga  aattttgtg  tgcccgatg  tgaccgccg  ggcatccag  960
aactttatg  gggtgagtc  gggttcccc  ccaagatgc  ccctcaacc  aggactacc  1020
cccggcctt  tgttcctga  aaacccaaa  accccacct  tgggcccaa  atctgtgac  1080
ggaactttg  caccgtggc  atgctccga  gggagatgt  tgtcttcaa  gagcgctgg  1140
tctggcggg  gaggaataa  caagtgatg  atggatacc  aatgcccat  ggccagttc  1200
ggcggggcc  gcctgcgtc  atcaacact  cctacgaga  gaaggatgg  aaattcgtc  1260
tcttcaaag  agacaagca  tgggtgttt  atgaggcgt  cctggaacc  ggctacccc  1320
agcacatta  ggagctggg  cgagggctg  ctaccgaca  gattgatgc  gctctcttc  1380
ggatgccca  tggaaagac  tacttcttc  gtggaaaca  gtactaccg  ttcaacgaa  1440
agctcaggg  agtggatag  gagtacccc  agaacatca  agtctggga  gggatccct  1500
agtctccca  agggtcatt  atgggcagc  atgaagtct  cacttactt  tacaagggg  1560
acaaatact  gaaattcaa  aaccagaag  tgaaggtag  accgggcta  cccaagtca  1620
ccctgaggg  ctggatggg  tgcccatcg  gaggccggc  cgatgaggg  actgaggag  1680
agacggagg  gatcatcat  gaggtggac  aggagggcg  cggggcggt  agcgctgct  1740
ccgtggtgc  gcccgtgct  ctgctgctc  tggtgctgg  ggtgggact  gcagtcttc  1800
tcttcagac  ccatgggac  cccaggcga  tgctctact  ccagcgttc  ctgctggac  1860
aggtctgac  cccaccgcc  gcccgccca  tcctaccac  aggactttg  ctctgaaga  1920
cagtgtcag  aaggtggtg  tgggtgggc  gctcccatc  gtccggagc  ccctccccg  1980
agcctcctt  cttctctca  tcccctggc  ggcctcctt  accctcacc  cctgtagct  2040
gtgtctgtc  agccccatc  gaatgtgtt  ggggctctg  acttgaagg  aggaccctc  2100
gacctcgct  gtaaaggtc  aatggggtc  tctgctcct  ttccatccc  tgacatacc  2160
taacctctg  actctgacc  caggaggct  tgggcactc  agccctgaa  gccccaagt  2220
tacccagtt  gcagcctcc  gtcactctg  ctaaaaaga  tcttcagag  gcatatttg  2280
aggtggaaa  attgttcag  taccctaaa  actttgaaa  aaagaaaga  agaaagaaa  2340
aaaaaaaaa  aaaaaaaaa  aaaaa  2365



<210> 10131
<211> 582
<212> PRT
<213> Homo sapiens
<308> P50281
<400> 10131

Met Ser Pro Ala Pro Arg Pro Ser Arg Cys Leu Leu Leu Pro Leu Leu 
  1               5                  10                  15
Thr Leu Gly Thr Ala Leu Ala Ser Leu Gly Ser Ala Gln Ser Ser Ser 
             20                  25                  30
Phe Ser Pro Glu Ala Trp Leu Gln Gln Tyr Gly Tyr Leu Pro Pro Gly 
         35                  40                  45
Asp Leu Arg Thr His Thr Gln Arg Ser Pro Gln Ser Leu Ser Ala Ala 
     50                  55                  60
Ile Ala Ala Met Gln Lys Phe Tyr Gly Leu Gln Val Thr Gly Lys Ala 
 65                  70                  75                  80
Asp Ala Asp Thr Met Lys Ala Met Arg Arg Pro Arg Cys Gly Val Pro 
                 85                  90                  95
Asp Lys Phe Gly Ala Glu Ile Lys Ala Asn Val Arg Arg Lys Arg Tyr 
             100                105                110
Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys Ile 
         115                120                125
Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala Ile 
     130                135                140
Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe Arg 
 145                150                155                160
Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala Asp 
                 165                170                175
Ile Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro Phe 
             180                185                190
Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Asn 
         195                200                205
Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val Arg 
     210                215                220
Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His Glu 
 225                230                235                240
Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile 
                 245                250                255
Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu Pro 
             260                265                270
Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Gly Glu Ser Gly 
         275                280                285
Phe Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro Ser 
     290                295                300
Val Pro Asp Lys Pro Lys Asn Pro Thr Tyr Gly Pro Asn Ile Cys Asp 
 305                310                315                320
Gly Asn Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe 
                 325                330                335
Lys Lys Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly 
             340                345                350
Tyr Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser Ile 
         355                360                365
Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys Gly 
     370                375                380
Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr Pro 
 385                390                395                400
Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile Asp 
                 405                410                415
Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg Gly 
             420                425                430
Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp Ser Glu 
         435                440                445
Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro Arg 
     450                455                460
Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys Gly 
 465                470                475                480
Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro Gly 
                 485                490                495
Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Gly Gly 
             500                505                510
Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile Glu 
         515                520                525
Val Asp Glu Glu Gly Gly Gly Ala Val Ser Ala Ala Ala Val Val Leu 
     530                535                540
Pro Val Leu Leu Leu Leu Leu Val Leu Ala Val Gly Leu Ala Val Phe 
 545                550                555                560
Phe Phe Arg Arg His Gly Thr Pro Arg Arg Leu Leu Tyr Cys Gln Arg 
                 565                570                575
Ser Leu Leu Asp Lys Val 
             580



<210> 10132
<211> 989
<212> DNA
<213> Rattus norvegicus
<308> X83579
<400> 10132

gagcgaacc  taatgagaa  ctggacttc  tcggagagg  acagtttgc  actgtctat  60
aggccagag  taagaacac  aaccagatc  tcgccatta  gaaaatcaa  cttggacac  120
ggtcagaag  taaagatgg  ataaataga  cagccttaa  ggagataaa  ctcttgcag  180
aactaagtc  tccaaatat  attggtctc  ttgatgcat  tggacataa  tcgaacatt  240
gccttgtct  tgattttat  gagactgac  tagaggtta  cataaagga  aacagtctc  300
tgttgaccc  atcccacat  aaagcctac  tgctgatga  tcttcaggg  ttggaatat  360
tacatcagc  ctggattct  cacagggat  tgaaaccaa  caacttgtt  ttagatgag  420
atggagttc  gaaactggc  gattttggc  tggccaaat  atttgggag  cccaattgg  480
cttacacac  tcaagttgt  accaggtgg  accgggccc  cgagttact  tttggagct  540
ggatgtacg  tgtgggagt  gacatgtgg  ctgtcggtt  tatcttagc  gaattgctt  600
taagggttc  ttttttgcc  ggagattca  accttgatc  gctaacaag  atatttgaa  660
ctctgggta  accaaccga  gaacagtgg  ctgacatgt  tagtcttcc  gattacgtg  720
cgttcaaga  tttccctgg  atccccctg  agcacatct  cattgcagc  ggagacgac  780
tgcttgagc  catacaagg  ttgttctta  tcaacccat  tactagaat  acagcttca  840
aggcgttga  gaccaagta  ttcagtaat  gtccagggc  aacacctgg  tgccagctt  900
caagaccaa  ctgtccagt  gaagcatta  aggaacagt  aaatccagc  atggcgaca  960
aacggaaaa  agcggaggc  ttagaacaa  989



<210> 10133
<211> 329
<212> PRT
<213> Rattus norvegicus
<308> P51952
<400> 10133

Ala Asn Arg Asn Glu Lys Leu Asp Phe Leu Gly Glu Gly Gln Phe Ala 
  1               5                  10                  15
Thr Val Tyr Lys Ala Arg Asp Lys Asn Thr Asn Gln Ile Val Ala Ile 
             20                  25                  30
Lys Lys Ile Lys Leu Gly His Arg Ser Glu Ala Lys Asp Gly Ile Asn 
         35                  40                  45
Arg Thr Ala Leu Arg Glu Ile Lys Leu Leu Gln Glu Leu Ser His Pro 
     50                  55                  60
Asn Ile Ile Gly Leu Leu Asp Ala Phe Gly His Lys Ser Asn Ile Ser 
 65                  70                  75                  80
Leu Val Phe Asp Phe Met Glu Thr Asp Leu Glu Val Ile Ile Lys Asp 
                 85                  90                  95
Asn Ser Leu Val Leu Thr Pro Ser His Ile Lys Ala Tyr Met Leu Met 
             100                105                110
Thr Leu Gln Gly Leu Glu Tyr Leu His Gln His Trp Ile Leu His Arg 
         115                120                125
Asp Leu Lys Pro Asn Asn Leu Leu Leu Asp Glu Asn Gly Val Leu Lys 
     130                135                140
Leu Ala Asp Phe Gly Leu Ala Lys Ser Phe Gly Ser Pro Asn Trp Ala 
 145                150                155                160
Tyr Thr His Gln Val Val Thr Arg Trp Tyr Arg Ala Pro Glu Leu Leu 
                 165                170                175
Phe Gly Ala Arg Met Tyr Gly Val Gly Val Asp Met Trp Ala Val Gly 
             180                185                190
Cys Ile Leu Ala Glu Leu Leu Leu Arg Val Pro Phe Leu Pro Gly Asp 
         195                200                205
Ser Asp Leu Asp Gln Leu Thr Arg Ile Phe Glu Thr Leu Gly Thr Pro 
     210                215                220
Thr Glu Glu Gln Trp Pro Asp Met Cys Ser Leu Pro Asp Tyr Val Thr 
 225                230                235                240
Phe Lys Ser Phe Pro Gly Ile Pro Leu Gln His Ile Phe Ile Ala Ala 
                 245                250                255
Gly Asp Asp Leu Leu Glu Leu Ile Gln Gly Leu Phe Leu Phe Asn Pro 
             260                265                270
Cys Thr Arg Ile Thr Ala Ser Gln Ala Leu Arg Thr Lys Tyr Phe Ser 
         275                280                285
Asn Arg Pro Gly Pro Thr Pro Gly Cys Gln Leu Pro Arg Pro Asn Cys 
     290                295                300
Pro Val Glu Ala Leu Lys Glu Gln Xaa Asn Pro Ala Met Ala Thr Lys 
 305                310                315                320
Arg Lys Arg Ala Glu Ala Leu Glu Gln 
                 325



<210> 10134
<211> 1259
<212> DNA
<213> Homo sapiens
<308> BC000834
<400> 10134

cccacgcgt  cggtcgggc  ttacggcgc  ggatggctc  ggacgtgaa  tctcgggca  60
agcgttatg  gaagctgga  ttccttggg  agggacagt  tgccaccgt  tacaaggcc  120
gagataaga  caccaacca  attgtcgcc  ttaagaaaa  caaacttgg  catagatca  180
aagctaaag  tggtataaa  agaaccgcc  taagagaga  aaaattatt  caggagcta  240
gtcatccaa  tataattgg  ctccttgat  cttttggac  taaatctaa  attagcctt  300
tctttgatt  tatggaaac  gatctagag  ttataataa  ggataatag  cttgtgctg  360
caccatcac  catcaaagc  tacatgttg  tgactcttc  aggattaga  tatttacat  420
aacattgga  cctacatag  gatctgaaa  caaacaact  gttgctaga  gaaaatgga  480
ttctaaaac  ggcagattt  ggcctggcc  aatcttttg  gagccccaa  agagcttat  540
cacatcagg  tgtaaccag  tggtatcgg  cccccgagt  actatttgg  gctaggatg  600
atggtgtag  tgtggacat  tgggctgtt  gctgtatat  agcagagtt  cttctaagg  660
ttccttttt  gccaggaga  tcagacctt  atcagctaa  aagaatatt  gaaactttg  720
gcacaccaa  tgaggaaca  tggccggac  tgtgtagtc  tccagatta  gtgacattt  780
agagtttcc  tggaatacc  ttgcatcac  tcttcagtg  agcaggaga  gacttacta  840
atctcatac  aggcttatt  ttatttaat  catgtgctc  aattacggc  acacaggca  900
tgaaaatga  gtatttcag  aatcggcca  ggccaacac  tggatgtca  ctgccaaga  960
caaactgtc  agtggaaac  ttaaaggag  aatcaaatc  agctttggc  ataaaaagg  1020
aaagaacag  ggccttaga  caaggagga  tgcccaaga  actaatttt  taaagagaa  1080
actggacaa  attttacta  tgagggaaa  agccaaaaa  gcaaataat  gaaaaatag  1140
aaacattaa  taaatgctg  agaagtgag  ttgtaaata  tctacacat  taaaatatg  1200
aaaactatg  gttattttt  ttaaatgta  tttaaaata  aaaaaaaaa  aaaaaaaaa  1259



<210> 10135
<211> 346
<212> PRT
<213> Homo sapiens
<308> P50613
<400> 10135

Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
  1               5                  10                  15
Phe Leu Gly Glu Gly Gln Phe Ala Thr Val Tyr Lys Ala Arg Asp Lys 
             20                  25                  30
Asn Thr Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
         35                  40                  45
Ser Glu Ala Lys Asp Gly Ile Asn Arg Thr Ala Leu Arg Glu Ile Lys 
     50                  55                  60
Leu Leu Gln Glu Leu Ser His Pro Asn Ile Ile Gly Leu Leu Asp Ala 
 65                  70                  75                  80
Phe Gly His Lys Ser Asn Ile Ser Leu Val Phe Asp Phe Met Glu Thr 
                 85                  90                  95
Asp Leu Glu Val Ile Ile Lys Asp Asn Ser Leu Val Leu Thr Pro Ser 
             100                105                110
His Ile Lys Ala Tyr Met Leu Met Thr Leu Gln Gly Leu Glu Tyr Leu 
         115                120                125
His Gln His Trp Ile Leu His Arg Asp Leu Lys Pro Asn Asn Leu Leu 
     130                135                140
Leu Asp Glu Asn Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Lys 
 145                150                155                160
Ser Phe Gly Ser Pro Asn Arg Ala Tyr Thr His Gln Val Val Thr Arg 
                 165                170                175
Trp Tyr Arg Ala Pro Glu Leu Leu Phe Gly Ala Arg Met Tyr Gly Val 
             180                185                190
Gly Val Asp Met Trp Ala Val Gly Cys Ile Leu Ala Glu Leu Leu Leu 
         195                200                205
Arg Val Pro Phe Leu Pro Gly Asp Ser Asp Leu Asp Gln Leu Thr Arg 
     210                215                220
Ile Phe Glu Thr Leu Gly Thr Pro Thr Glu Glu Gln Trp Pro Asp Met 
 225                230                235                240
Cys Ser Leu Pro Asp Tyr Val Thr Phe Lys Ser Phe Pro Gly Ile Pro 
                 245                250                255
Leu His His Ile Phe Ser Ala Ala Gly Asp Asp Leu Leu Asp Leu Ile 
             260                265                270
Gln Gly Leu Phe Leu Phe Asn Pro Cys Ala Arg Ile Thr Ala Thr Gln 
         275                280                285
Ala Leu Lys Met Lys Tyr Phe Ser Asn Arg Pro Gly Pro Thr Pro Gly 
     290                295                300
Cys Gln Leu Pro Arg Pro Asn Cys Pro Val Glu Thr Leu Lys Glu Gln 
 305                310                315                320
Ser Asn Pro Ala Leu Ala Ile Lys Arg Lys Arg Thr Glu Ala Leu Glu 
                 325                330                335
Gln Gly Gly Leu Pro Lys Lys Leu Ile Phe 
             340                345



<210> 10136
<211> 2321
<212> DNA
<213> Rattus norvegicus
<308> X83867
<400> 10136

caagacacc  ctgcgacgc  agcttgaaa  ccgccggcg  gctgggatt  agctccact  60
tatcaactc  caacccctc  cccatctca  ccgcaactc  aactctgtg  gaaagtcct  120
actttgcgg  gccccaggt  cactggagc  cagcaaact  gagacactt  ccccctgtc  180
tccatccta  tctaagttt  ggttctgac  gagccaaga  tgggtgcta  agcagcggg  240
ctcaggtgt  taggactcc  ggtccttgg  gactctcag  ttgaagtct  gcagagtct  300
ggcagaggc  ccagagctt  tcccagacc  cactgctct  caccgctgg  accgcgctt  360
atcgcaggt  acatggcca  cagccttag  gcagacagt  cacagcagc  gagctcgct  420
tctacccaa  agaccattc  tctgctact  gtttcggtc  tggccatcg  gcacttagg  480
cagtggctg  tgcgccagt  gcgacggaa  ccgtggtcc  cgcccccgg  tccctttcc  540
tggccattg  tcggaaacg  ggcgtctgt  ggccgggca  cgcacttgt  cttcgctcg  600
cttgcgagg  gctatggcg  cgtttttca  atccgtctg  gcagctgtc  cgtggtggt  660
ctgaatggc  agagtgcca  ccatcaggc  ctggtgcag  agggcggcg  ctttgcgga  720
cggcctccc  tcgcctctt  ccgtgtggt  tctggtggc  gcagcctgg  gttcggcca  780
tactcagag  gctggaagg  gcggcgacg  gcagcctat  gcacgatgc  tgccttctc  840
acccgccac  cgcgcagcc  cggtctcct  gagggccac  cgctgggag  ggctcgaga  900
ttggtggca  tgttggtgc  gcgctgcgc  ggtggcgcc  gcctcgatc  gacgcagcc  960
atcatagtg  cggtggcta  tgtcatgag  gctgtatgc  tcggctgtc  gtacaacca  1020
gacgatgcc  agttcctgg  gctgctcag  cacaacgag  agttcgggc  caccgtggg  1080
gcgggcagc  tggtggacg  gatgccctg  ctgcagctt  ttcccaacc  ggtgcgcac  1140
atcttccgc  agttcgagc  gatcaaccg  aacttcagc  acttcgtcc  ggacaagtt  1200
ctgaggcac  gagaaagcc  cgtgcccgg  gctgctcct  gagacatga  ggacgcctt  1260
atcctctcc  ccgaaaaga  ggcgactgg  gaccctggt  acagtccct  cgggctgga  1320
ttggaggat  tgcctgcca  tattacaga  atctttgga  ccagccagg  caccctttc  1380
accgcgctg  tgtggctgc  catcctctt  accagatac  cggatgtgc  ggcccgagt  1440
caggccgag  tggaccagg  tgtggggag  gaccgcctg  cctgcatga  tgaccaacc  1500
aacttacca  acgtcatgg  ttttcttta  gaatccatg  gattcacca  ctttttgcc  1560
gtcaccctt  cacatgcca  cactgccaa  acctttgtt  taggctact  catccccaa  1620
aacacggta  tttttgtta  ccagtggtc  gtgaatcat  acccagcaa  gtggtctaa  1680
ccagaggac  ttgatccgg  ccgcttcct  gacaaggac  gcttcatta  caaggcact  1740
gccagcagc  tgatgatat  ttcagtggg  aaacgacgg  gcatcggcg  ggagttgtc  1800
aagacgctt  tgtttctct  catctccat  ctcgctcat  agtgcaatt  caaggctaa  1860
caaaacgag  cctcaaaca  gagtttcag  tacggcctg  gcattaagc  caagtcgtt  1920
aaaatccat  tgtctctca  agagtccat  aagctcctt  atagtgctg  cgagaagct  1980
caagctgag  aagcttgcc  gtgagagag  gagaggccg  agtaactga  atgttcaaa  2040
aaagccatc  cattaactg  agaggaaaa  acagatttt  ttttctcca  cttcatttt  2100
gcctcagtt  tcaagaatg  gcggaaacc  agtggcctg  aggtgaggc  ggcttacca  2160
ttcatggct  ctcaccggc  agcagctgg  gatcctgaa  tattttgaa  ttgaagagt  2220
atagggtcc  aggaatttg  atactgttc  cccctcacc  ccattaaac  catgcacac  2280
aatcagcat  tgtgtacag  tatccaaca  aatatttca  t  2321



<210> 10137
<211> 543
<212> PRT
<213> Rattus norvegicus
<308> Q64678
<400> 10137

Met Ala Thr Ser Leu Ser Ala Asp Ser Pro Gln Gln Leu Ser Ser Leu 
  1               5                  10                  15
Ser Thr Gln Gln Thr Ile Leu Leu Leu Leu Val Ser Val Leu Ala Ile 
             20                  25                  30
Val His Leu Gly Gln Trp Leu Leu Arg Gln Trp Arg Arg Lys Pro Trp 
         35                  40                  45
Ser Ser Pro Pro Gly Pro Phe Pro Trp Pro Leu Ile Gly Asn Ala Ala 
     50                  55                  60
Ser Val Gly Arg Ala Ser His Leu Tyr Phe Ala Arg Leu Ala Arg Arg 
 65                  70                  75                  80
Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Val Val Val 
                 85                  90                  95
Leu Asn Gly Glu Ser Ala Ile His Gln Ala Leu Val Gln Gln Gly Gly 
             100                105                110
Val Phe Ala Asp Arg Pro Pro Phe Ala Ser Phe Arg Val Val Ser Gly 
         115                120                125
Gly Arg Ser Leu Ala Phe Gly His Tyr Ser Glu Arg Trp Lys Glu Arg 
     130                135                140
Arg Arg Ala Ala Tyr Gly Thr Met Arg Ala Phe Ser Thr Arg His Pro 
 145                150                155                160
Arg Ser Arg Gly Leu Leu Glu Gly His Ala Leu Gly Glu Ala Arg Glu 
                 165                170                175
Leu Val Ala Val Leu Val Arg Arg Cys Ala Gly Gly Ala Cys Leu Asp 
             180                185                190
Pro Thr Gln Pro Ile Ile Val Ala Val Ala Asn Val Met Ser Ala Val 
         195                200                205
Cys Phe Gly Cys Arg Tyr Asn His Asp Asp Ala Glu Phe Leu Glu Leu 
     210                215                220
Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
 225                230                235                240
Val Asp Val Met Pro Trp Leu Gln Leu Phe Pro Asn Pro Val Arg Thr 
                 245                250                255
Ile Phe Arg Glu Phe Glu Gln Ile Asn Arg Asn Phe Ser Asn Phe Val 
             260                265                270
Leu Asp Lys Phe Leu Arg His Arg Glu Ser Leu Val Pro Gly Ala Ala 
         275                280                285
Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
     290                295                300
Thr Gly Asp Pro Gly Asp Ser Pro Ser Gly Leu Asp Leu Glu Asp Val 
 305                310                315                320
Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                 325                330                335
Thr Ala Leu Leu Trp Leu Leu Ile Leu Phe Thr Arg Tyr Pro Asp Val 
             340                345                350
Gln Ala Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
         355                360                365
Leu Pro Cys Met Ser Asp Gln Pro Asn Leu Pro Tyr Val Met Ala Phe 
     370                375                380
Leu Tyr Glu Ser Met Arg Phe Thr Ser Phe Leu Pro Val Thr Leu Pro 
 385                390                395                400
His Ala Thr Thr Ala Asn Thr Phe Val Leu Gly Tyr Tyr Ile Pro Lys 
                 405                410                415
Asn Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Ala 
             420                425                430
Lys Trp Ser Asn Pro Glu Asp Phe Asp Pro Ala Arg Phe Leu Asp Lys 
         435                440                445
Asp Gly Phe Ile Asn Lys Ala Leu Ala Ser Ser Val Met Ile Phe Ser 
     450                455                460
Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Thr Leu Leu 
 465                470                475                480
Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asn Phe Lys Ala Asn 
                 485                490                495
Gln Asn Glu Pro Ser Asn Met Ser Phe Ser Tyr Gly Leu Ser Ile Lys 
             500                505                510
Pro Lys Ser Phe Lys Ile His Val Ser Leu Arg Glu Ser Met Lys Leu 
         515                520                525
Leu Asp Ser Ala Val Glu Lys Leu Gln Ala Glu Glu Ala Cys Gln 
     530                535                540



<210> 10138
<211> 5102
<212> DNA
<213> Homo sapiens
<308> U03688
<400> 10138

gcttctgcg  ctccagttg  gagagccgc  agggcatgg  aattgacgc  actcaccga  60
ccccagtct  aatctcaac  ctgtgagga  acctcgact  tgccaggtc  ccaagggca  120
cggggctcg  cgagcgagg  acccttctc  gtccccatc  caatccaag  gctcctggc  180
ctgacgacg  caagagact  gagtgggag  taaagcttc  agtgagggc  gcaggtgtc  240
aggccgggc  tgcgggttc  tgttgacgt  ttgccctag  caaaggtcc  agttccttc  300
cggagccgg  tgtcccgcg  cactggaaa  cgcacctcc  cgcagcatg  gcaccagcc  360
cagcccgaa  gacccttgg  cgctaaacc  gctgtccat  cagcagacc  cgctcctgc  420
actcctgtc  gtgctggcc  ctgtgcatg  gggccagcg  ctgctgagg  aacggaggc  480
gcagctccg  tccgcgccc  cgggcccgt  tgcgtggcc  ctgatcgga  acgcggcgg  540
ggtgggcca  gcggctcac  tctcgttcg  tcgcctggc  cggcgctac  gcgacgttt  600
ccagatccg  ctgggcagc  gccccatag  ggtgctgaa  ggcgagcgc  ccatccacc  660
ggccctggt  cagcagggc  cggccttcg  cgaccggcc  gccttcgcc  ccttccgtg  720
ggtgtccgg  ggccgcagc  tggctttcg  ccactactc  gagcactgg  aggtgcagc  780
gcgcgcagc  cacagcatg  tgcgcaact  cttcacgcg  cagccgcgc  gccgccaag  840
cctcgaggg  cacgtgctg  gcgaggcgc  cgagctggt  gcgctgctg  tgcgcggca  900
cgcggacgg  gccttcctc  acccgaggc  gctgaccgt  gtggccgtg  ccaacgtca  960
gagtgccgt  tgtttcggc  gccgctaca  ccacgacga  cccgagttc  gtgagctgc  1020
cagccacaa  gaagagttc  ggcgcacgg  gggcgcggg  agcctggtg  acgtgatgc  1080
ctggctgca  tacttcccc  acccggtgc  caccgtttt  cgcgaattc  agcagctca  1140
ccgcaactt  agcaacttc  tcctggaca  gttcttgag  cactgcgaa  gccttcggc  1200
cggggccgc  ccccgcgac  tgatggacg  ctttatcct  tctgcggaa  agaaggcgg  1260
cggggactc  cacggtggt  gcgcgcggc  ggatttgga  aacgtaccg  ccactatca  1320
tgacatctt  ggcgccagc  aggacaccc  gtccaccgc  ctgcagtgg  tgctcctcc  1380
cttcaccag  tatcctgat  tgcagactc  agtgcaggc  gaattggat  aggtcgtgg  1440
gagggaccg  ctgccttgt  tgggtgacc  gcccaacct  ccctatgtc  tggccttcc  1500
ttatgaagc  atgcgcttc  ccagctttg  gcctgtcac  attcctcat  ccaccactg  1560
caacacctc  gtcttgggc  accacattc  caaggacac  gtggttttt  tcaaccagt  1620
gtctgtgaa  catgaccca  tgaagtggc  taacccgga  aactttgat  cagctcgat  1680
cttggacaa  gatggcctc  tcaacaagg  cctgaccag  agagtgatg  ttttttcag  1740
gggcaaaag  cggtgcatt  gcgaagaac  ttctaagat  cagcttttt  tcttcatct  1800
catcctggc  caccagtgc  atttcaggg  caacccaaa  gagcctgcg  aaatgaatt  1860
cagttatgg  ctaaccatt  aacccaagt  atttaaagt  aatgtcact  tcagagagt  1920
catggagct  cttgatagt  ctgtccaaa  tttacaagc  aaggaaact  gccaataag  1980
agcaagagg  aagctgaaa  tttagaaat  ttcacatct  cggagatga  gagtaaaat  2040
cagtttttt  ccagttcct  ttttgtgct  cttctcaat  agcgtttaa  gtgagcata  2100
atcaactgt  catcaggtg  ggtgtgctc  atacccagc  gttcttcat  agtagtggg  2160
tatgcagga  cttctggga  atttttttg  gtcaaagac  taaagggcc  aatgaatta  2220
tatatacat  ctgcatctt  gttatttct  aaggtagca  tctttggag  taaaatgca  2280
atatagaca  atacaccca  acacttaca  caaactact  aatgaagaa  tattttggt  2340
accaggcca  ttttggtgg  aatccaaga  tggtctccc  tatgcagaa  tagacaaaa  2400
gtatattaa  caaagtttc  gagtatatt  ttgaagaga  agagacaag  aatttcagt  2460
taaagtgtg  gattgaagg  gataaggga  aagataaag  ccagaaatt  ccttttcac  2520
ttttcagga  aataactta  actctagta  ttatgggtg  atttatcct  ttgccttct  2580
gtatacttc  ttactttta  ggataaatc  taaagtcag  tgctcaaaa  gaaatcaat  2640
gttgaatta  tgagtatag  ggggttcca  gagttatca  gaattttaa  gtatgcatt  2700
ttaaattgt  aaactccaa  gtgatgttg  acctctttt  cttgccaaa  tacagaatt  2760
gaattatca  caaagaaaa  aaaaaaagc  agccaagct  taaattatg  gaccataat  2820
tactgattt  agtaagtct  ataggttaa  aaaaaaagt  accaaatag  gtgaaatat  2880
ttacttaac  gtccgtaag  agtatatta  tattatctt  ttcaggaaa  ggttgaata  2940
tatatgcct  gtgtaatat  gaaaattga  aagtacaac  aacgcaacc  agtgtgcta  3000
aaatgagct  gattaaatc  accacctat  tttgacatg  aaatgaagc  gggtttctt  3060
tcttcactc  aattttggc  aatctcaaa  ttagatcct  agatgtgtt  ttattttta  3120
aacatcttt  ttgaaattc  atttataat  cagaatctt  ttttgaaaa  aacctaatt  3180
atatattaa  attccaaat  catggcatg  ttaaatttt  actaaattt  aaagccatt  3240
tgattattg  gttccagtt  aagttagtg  aaatctgaa  attctcctg  ggaaggcag  3300
gaaatctaa  ctgtgtctg  ccaatgaat  atggaaaat  ccatgaatt  cctggatgt  3360
ctttttacg  ggtgacaag  gttggggac  gaactccca  tacaactga  caagtttct  3420
ttctagatg  ttttttgaa  gttaacatt  atgcctgct  tttggaaag  cagaatcag  3480
agatagtct  ggaagctgt  tggaaaaga  agtggagat  aggtcagtt  tgtttttta  3540
gatggcaat  actttggta  ctgggaaag  ataaagctc  aatgaaatg  atgcattca  3600
atttagaaa  gtgaattga  gtttcaagt  ttaaagttc  ttgcaatta  acttccaaa  3660
aaagttcta  agtgtccta  gtgctaagt  cttattaca  tttattaag  tttttggaa  3720
ctttgtacc  aaattttaa  aaagggagt  tttgatagt  gtgtgtatg  gtgtgtggg  3780
tggggggat  gtaagagaa  agagagaaa  actgaaaag  aggaaagat  gttaaacat  3840
ttcccactc  ttctgaatt  attaatttg  agcacaaaa  tcaaagcat  gacatttag  3900
agaaagatg  ttggcgtag  agagttaaa  ctcaaatag  ctattaaaa  agtctacaa  3960
atagcagat  tgttttgtg  tttggaata  taaaaaact  catgtaatt  tattttaaa  4020
tttcatagc  gtacttctt  aatataaaa  atcatgcca  tatttttaa  ggcattaga  4080
tcaactaca  aaagcaggc  tgcccagta  atttaaatt  tttggcact  gccattcca  4140
aatattatg  cccaccaag  ctgagacag  gaatttggg  tgctgtagc  tattttttt  4200
gattgagaa  tgtgtagct  caaaaataa  catgaacca  tctggatgc  tcattatgt  4260
aaccaggtc  agatgtgct  taatctgtt  ttacgtatg  aggcccagt  gtcatcaga  4320
gcttgcggc  aaagaaagc  gtgtttata  ggaagaaag  aaggtgctt  gagtttacc  4380
ggcttattt  atatgctta  aacctagtt  aagaaagga  aagaaaaca  aaaacgaat  4440
aaaataact  aatttggag  ctggagtaa  cagattact  ctttaatca  aaaccctca  4500
tgtgtttct  ccggagaga  aatgtattt  ctgacaacc  ttaaagtca  aagttttac  4560
ccaggttat  gcaataaag  ataatgttt  ttaaatgct  catttgtat  tcaaagctt  4620
gactctata  gcaaattgc  tttttccaa  acaaaaaga  gtctcaggt  tgttttgtg  4680
attttctaa  agctttcat  tcccagaac  tagccttta  ctgtgaagt  ttactacag  4740
cttaatatt  tcctagtag  tctatatta  atcaaatag  tgcatagca  tatatgtta  4800
tttgtgtgt  tttagctgt  acacaactg  gtgattaaa  ggtatactt  agtagacat  4860
tataactca  ggatacctt  ttatttaat  ttttcttat  tttgtactt  atcatgaat  4920
cttttagtg  gtgcataat  gctacagtg  atagttgta  acaaagtac  ttctgggga  4980
acaacattt  tatgtagcc  ttactgttt  atataccaa  ttaaaaaaa  attgtatct  5040
attacttat  ctgggacac  attaccaaa  taataaaaa  cactttcat  atcttgaaa  5100
aa  5102



<210> 10139
<211> 543
<212> PRT
<213> Homo sapiens
<308> Q16678
<400> 10139

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
  1               5                  10                  15
Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
             20                  25                  30
Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
         35                  40                  45
Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
     50                  55                  60
Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
 65                  70                  75                  80
Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                 85                  90                  95
Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
             100                105                110
Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
         115                120                125
Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
     130                135                140
Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
 145                150                155                160
Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                 165                170                175
Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
             180                185                190
Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
         195                200                205
Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
     210                215                220
Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
 225                230                235                240
Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                 245                250                255
Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
             260                265                270
Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
         275                280                285
Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
     290                295                300
Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
 305                310                315                320
Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                 325                330                335
Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
             340                345                350
Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
         355                360                365
Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
     370                375                380
Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
 385                390                395                400
His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                 405                410                415
Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Val 
             420                425                430
Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
         435                440                445
Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
     450                455                460
Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
 465                470                475                480
Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                 485                490                495
Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
             500                505                510
Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
         515                520                525
Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
     530                535                540



<210> 10140
<211> 3276
<212> DNA
<213> Rattus norvegicus
<308> X84210
<400> 10140

cgaccgacc  gcagttgag  cgagttgga  atgtgaacg  aagaagcag  cttgatttt  60
ttttcctcc  cccctctcc  agctctctc  tcctctctc  ccctctcgc  cccacactc  120
cgcacacct  cagcccgca  acagacgtg  acgcacccc  cgccgcccg  cagttatgt  180
ttctccgct  tgtctcacc  aggatgagt  tcatccttt  attgaagca  ttctgcccc  240
tgtccgcgc  ttcgcctac  catggttca  cctgcaggc  cgaaagcgg  aatacttca  300
aaagcatga  aagcgcatg  cgaaagaag  ggagagggc  gtgaaggat  aactgctaa  360
tgagaagcc  gaggtcaag  aaaagtggg  ttcccgact  ctggccaag  tacggaaag  420
tatccgacc  gagtaccga  aggattttg  tcttacagt  acagggaaa  aacctccat  480
ctgtgttct  tccaaccca  accagaaag  caagatgcg  agaattgac  gcctccgcc  540
ggcagataa  gtatggagg  tggacctcg  catggtgat  ttgttcaaa  gtattccgc  600
ggaaagtac  gatggtgaa  gccttgtga  gtccccaca  tgctcgaat  cagggctct  660
tgtccagcc  catcacata  gggtttctg  aaaggaact  gatttatat  tggcatact  720
tgtacatgc  gcagattca  gtcaatctg  aagtcccag  caaccaagt  atgctgaca  780
taaggacca  ccagaaaat  gacatttgg  cttccagga  agcttcgtc  catcaggtg  840
tttcagtgt  actgagcta  taagagtgt  acaaacacc  atagctgca  gaaccggcc  900
caatttttc  ctctctgat  tggaaagtt  ctcatacta  agcatgagt  caggagcaa  960
gaggaggtc  ctacccagc  catcctcta  cagctctac  aagcgcctc  agtctgtgg  1020
ggacgaaat  gacagtcct  gtgaagaac  attttacac  ggccaaggg  gctccccag  1080
gagtggcag  cagtccagc  gatggcatg  agtagagcc  ggcatgcca  ctccaacca  1140
tctgaagaa  tctgagaag  ctggtttca  cagcccctc  ccttcgcag  cctcctccc  1200
cggaacagc  ttcacacag  atcaccgac  tgtcataac  ggaccgaga  caagcccac  1260
tgcgacgcc  tcgactctc  actttccaa  gtcacctat  atccagcag  ctgggcctt  1320
tttctcaca  ccagccatc  gttaccacc  tcaggagac  ctgaaggag  ttgtccaac  1380
tgtctgccc  gatgctggt  agcaagctg  acaggtggg  ttcctcaat  ccaatggaa  1440
cagtcaagg  aaggtgcac  acccattcc  ccccacccc  atgttgccg  cgccaccgc  1500
accaccgat  gccaggcct  tgcctctgc  catgccaga  accaagcct  caaccacat  1560
aacagaagg  ggtgcagcc  cccccacct  accgatcct  gtacctggg  taaaagttg  1620
agcgtccca  catcctcca  acagaccac  tgacccctt  tcaactctg  aacatggac  1680
caacctcaa  ccggcgcag  tacaacttc  ctgtcagtg  aaggggaga  acaccaact  1740
gaatcaact  gtacatgga  acagcgaac  tcgtggtca  acagcaaag  cccataact  1800
ttcgggatt  ttttttttt  ttaatactt  agggactgt  gaattctct  aatatggtg  1860
tggaaatgc  ttgggctgt  tgacatttg  agtgttcca  tggtggtgt  agcagtagg  1920
gaagcggct  gtaggggat  agccttgct  acgaacttc  tgttgtaac  cttttgagc  1980
tggcctttt  acagtattt  aagaatttg  ccgcgcagg  gtgtgaccc  cccggagca  2040
ttggagaca  ctggagaat  aaatctttc  tagtagcta  gatctgtga  ctgtaactt  2100
caggacact  aagggcaat  tttttgggg  tttcttttt  ttctgtaac  tattagaaa  2160
agcaatgca  ttaagttat  tttctttta  tttggtttg  ttcagcagt  agcagttaa  2220
tacataaca  aaccctcaa  gacagtgaa  ccactcatg  tgcagagca  tccaaaaag  2280
cagcaaaga  tactactac  actctcagt  cggttgttt  ttttttttt  ttttttttt  2340
tttttttat  aagttttga  atgctgcac  tacatttaa  aaaaacatt  tcaacaatt  2400
caacaatga  acaaaagtt  acatggaaa  ggggaagat  gtctgtttt  acagaaact  2460
acaggaatc  aaacaatcg  attttgaat  gagtgaagt  caatttcat  ggatagcta  2520
gtatctttg  aagatagag  ttgttgaaa  ttctatttt  gtttttcaa  tcctcccac  2580
ccaggactc  aaattattg  ggttaaaaa  aaacagcct  gcaagaaaa  ggggagcta  2640
ttttgcttt  tatgttttt  attgttaaa  ttgtatccc  ttaaaaaaa  aaaccgaag  2700
aaaatttaa  aaaaaagca  aaaaaaaaa  tacaaatct  atggtgctt  tacctccaa  2760
atgttaact  cattaaatg  taattaatt  ttttctgtt  tcaaagcac  taactcaaa  2820
gaaatcatg  tatctgtta  ttttataag  tagaaatca  tataatgaa  tatgccaat  2880
ctggaaaat  ttacacatg  atggcaaca  cagatctat  ggttttcaa  cgcctcgtc  2940
taaccagac  ttgtccaga  gtttcaaag  cccttcgca  accctgaat  ggctacggg  3000
aatatatca  atcgataag  acataactg  gtgagccat  cagatcaaa  tacttgtta  3060
gaaaataaa  aaacaaaca  aaacaaaat  ttcacacac  cacacaccc  aaatgtctt  3120
tatcttatg  ttaaggaaa  agaaaagac  aaacggcac  agggtctga  caccatgac  3180
acctacagc  acaaggacc  aagctgaga  aggcgtctc  ttcactcgt  accttctgg  3240
ggcaccgag  aggctgctc  cttgcacag  tggttg  3276



<210> 10141
<211> 509
<212> PRT
<213> Rattus norvegicus
<308> P09414
<400> 10141

Met Tyr Ser Pro Leu Cys Leu Thr Gln Asp Glu Phe His Pro Phe Ile 
  1               5                  10                  15
Glu Ala Leu Leu Pro His Val Arg Ala Phe Ala Tyr Thr Trp Phe Asn 
             20                  25                  30
Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg Met 
         35                  40                  45
Ser Lys Glu Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Ser Glu Lys 
     50                  55                  60
Pro Glu Val Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu Arg 
 65                  70                  75                  80
Lys Asp Ile Arg Pro Glu Tyr Arg Glu Asp Phe Val Leu Thr Val Thr 
                 85                  90                  95
Gly Lys Lys Pro Pro Cys Cys Val Leu Ser Asn Pro Asp Gln Lys Gly 
             100                105                110
Lys Met Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp Arg 
         115                120                125
Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu Ser 
     130                135                140
Thr Asp Gly Glu Arg Leu Val Lys Ser Pro Gln Cys Ser Asn Pro Gly 
 145                150                155                160
Leu Cys Val Gln Pro His His Ile Gly Val Ser Val Lys Glu Leu Asp 
                 165                170                175
Leu Tyr Leu Ala Tyr Phe Val His Ala Ala Asp Ser Ser Gln Ser Glu 
             180                185                190
Ser Pro Ser Gln Pro Ser Asp Ala Asp Ile Lys Asp Gln Pro Glu Asn 
         195                200                205
Gly His Leu Gly Phe Gln Asp Ser Phe Val Thr Ser Gly Val Phe Ser 
     210                215                220
Val Thr Glu Leu Val Arg Val Ser Gln Thr Pro Ile Ala Ala Gly Thr 
 225                230                235                240
Gly Pro Asn Phe Ser Leu Ser Asp Leu Glu Ser Ser Ser Tyr Tyr Ser 
                 245                250                255
Met Ser Pro Gly Ala Met Arg Arg Ser Leu Pro Ser Thr Ser Ser Thr 
             260                265                270
Ser Ser Thr Lys Arg Leu Lys Ser Val Glu Asp Glu Met Asp Ser Pro 
         275                280                285
Gly Glu Glu Pro Phe Tyr Thr Gly Gln Gly Arg Ser Pro Gly Ser Gly 
     290                295                300
Ser Gln Ser Ser Gly Trp His Glu Val Glu Pro Gly Met Pro Ser Pro 
 305                310                315                320
Thr Thr Leu Lys Lys Ser Glu Lys Ser Gly Phe Ser Ser Pro Ser Pro 
                 325                330                335
Ser Gln Thr Ser Ser Leu Gly Thr Ala Phe Thr Gln His His Arg Pro 
             340                345                350
Val Ile Thr Gly Pro Arg Ala Ser Pro His Ala Thr Pro Ser Thr Leu 
         355                360                365
His Phe Pro Thr Ser Pro Ile Ile Gln Gln Pro Gly Pro Tyr Phe Ser 
     370                375                380
His Pro Ala Ile Arg Tyr His Pro Gln Glu Thr Leu Lys Glu Phe Val 
 385                390                395                400
Gln Leu Val Cys Pro Asp Ala Gly Gln Gln Ala Gly Gln Val Gly Phe 
                 405                410                415
Leu Asn Pro Asn Gly Ser Ser Gln Gly Lys Val His Asn Pro Phe Leu 
             420                425                430
Pro Thr Pro Met Leu Pro Pro Pro Pro Pro Pro Pro Met Ala Arg Pro 
         435                440                445
Val Pro Leu Pro Met Pro Asp Thr Lys Pro Pro Thr Thr Ser Thr Glu 
     450                455                460
Gly Gly Ala Ala Ser Pro Thr Ser Pro Thr Tyr Ser Thr Pro Ser Thr 
 465                470                475                480
Ser Pro Ala Asn Arg Phe Val Ser Val Gly Pro Arg Asp Pro Ser Phe 
                 485                490                495
Val Asn Ile Pro Gln Gln Thr Gln Ser Trp Tyr Leu Gly 
             500                505



<210> 10142
<211> 502
<212> PRT
<213> Homo sapiens
<308> AAC15752
<400> 10142

Met Tyr Ser Pro Tyr Cys Leu Thr Gln Asp Glu Phe His Pro Phe Ile 
  1               5                  10                  15
Glu Ala Leu Leu Pro His Val Arg Ala Phe Ser Tyr Thr Trp Phe Asn 
             20                  25                  30
Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg Met 
         35                  40                  45
Ser Lys Asp Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Gly Glu Lys 
     50                  55                  60
Pro Glu Ile Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu Arg 
 65                  70                  75                  80
Lys Asp Ile Arg Pro Glu Phe Arg Glu Asp Phe Val Leu Thr Ile Thr 
                 85                  90                  95
Gly Lys Lys Pro Pro Cys Cys Val Leu Ser Asn Pro Asp Gln Lys Gly 
             100                105                110
Lys Ile Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp Arg 
         115                120                125
Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu Ser 
     130                135                140
Thr Asp Gly Glu Arg Leu Tyr Lys Ser Pro Gln Cys Ser Asn Pro Gly 
 145                150                155                160
Leu Cys Val Gln Pro His His Ile Gly Val Thr Ile Lys Glu Leu Asp 
                 165                170                175
Leu Tyr Leu Ala Tyr Phe Val His Thr Pro Glu Ser Gly Gln Ser Asp 
             180                185                190
Ser Ser Asn Gln Gln Gly Asp Ala Asp Ile Lys Pro Leu Pro Asn Gly 
         195                200                205
His Leu Ser Phe Gln Asp Cys Phe Val Thr Ser Gly Val Trp Asn Val 
     210                215                220
Thr Glu Leu Val Arg Val Ser Gln Thr Pro Val Ala Thr Ala Ser Gly 
 225                230                235                240
Pro Asn Phe Ser Leu Ala Asp Leu Glu Ser Pro Ser Tyr Tyr Asn Ile 
                 245                250                255
Asn Gln Val Thr Leu Gly Arg Arg Ser Ile Thr Ser Pro Pro Ser Thr 
             260                265                270
Ser Thr Thr Lys Arg Pro Lys Ser Ile Asp Asp Ser Glu Met Glu Ser 
         275                280                285
Pro Val Asp Asp Val Phe Tyr Pro Gly Thr Gly Arg Ser Pro Ala Ala 
     290                295                300
Gly Ser Ser Gln Ser Ser Gly Trp Pro Asn Asp Val Asp Ala Gly Pro 
 305                310                315                320
Ala Ser Leu Lys Lys Ser Gly Lys Leu Asp Phe Cys Ser Ala Leu Ser 
                 325                330                335
Ser Gln Gly Ser Ser Pro Arg Met Ala Phe Thr His His Pro Leu Pro 
             340                345                350
Val Leu Ala Gly Val Arg Pro Gly Ser Pro Arg Ala Thr Ala Ser Ala 
         355                360                365
Leu His Phe Pro Ser Thr Ser Ile Ile Gln Gln Ser Ser Pro Tyr Phe 
     370                375                380
Thr His Pro Thr Ile Arg Tyr His His His His Gly Gln Asp Ser Leu 
 385                390                395                400
Lys Glu Phe Val Gln Phe Val Cys Ser Asp Gly Ser Gly Gln Ala Thr 
                 405                410                415
Gly Gln Pro Asn Gly Ser Gly Gln Gly Lys Val Pro Gly Ser Phe Leu 
             420                425                430
Leu Pro Pro Pro Pro Pro Val Ala Arg Pro Val Pro Leu Pro Met Pro 
         435                440                445
Asp Ser Lys Ser Thr Ser Thr Ala Pro Asp Gly Ala Ala Leu Thr Pro 
     450                455                460
Pro Ser Pro Ser Phe Ala Thr Thr Gly Ala Ser Ser Ala Asn Arg Phe 
 465                470                475                480
Val Ser Ile Gly Pro Arg Asp Gly Asn Phe Leu Asn Ile Pro Gln Gln 
                 485                490                495
Ser Gln Ser Trp Phe Leu 
             500



<210> 10143
<211> 3276
<212> DNA
<213> Rattus norvegicus
<308> X84210
<400> 10143

cgaccgacc  gcagttgag  cgagttgga  atgtgaacg  aagaagcag  cttgatttt  60
ttttcctcc  cccctctcc  agctctctc  tcctctctc  ccctctcgc  cccacactc  120
cgcacacct  cagcccgca  acagacgtg  acgcacccc  cgccgcccg  cagttatgt  180
ttctccgct  tgtctcacc  aggatgagt  tcatccttt  attgaagca  ttctgcccc  240
tgtccgcgc  ttcgcctac  catggttca  cctgcaggc  cgaaagcgg  aatacttca  300
aaagcatga  aagcgcatg  cgaaagaag  ggagagggc  gtgaaggat  aactgctaa  360
tgagaagcc  gaggtcaag  aaaagtggg  ttcccgact  ctggccaag  tacggaaag  420
tatccgacc  gagtaccga  aggattttg  tcttacagt  acagggaaa  aacctccat  480
ctgtgttct  tccaaccca  accagaaag  caagatgcg  agaattgac  gcctccgcc  540
ggcagataa  gtatggagg  tggacctcg  catggtgat  ttgttcaaa  gtattccgc  600
ggaaagtac  gatggtgaa  gccttgtga  gtccccaca  tgctcgaat  cagggctct  660
tgtccagcc  catcacata  gggtttctg  aaaggaact  gatttatat  tggcatact  720
tgtacatgc  gcagattca  gtcaatctg  aagtcccag  caaccaagt  atgctgaca  780
taaggacca  ccagaaaat  gacatttgg  cttccagga  agcttcgtc  catcaggtg  840
tttcagtgt  actgagcta  taagagtgt  acaaacacc  atagctgca  gaaccggcc  900
caatttttc  ctctctgat  tggaaagtt  ctcatacta  agcatgagt  caggagcaa  960
gaggaggtc  ctacccagc  catcctcta  cagctctac  aagcgcctc  agtctgtgg  1020
ggacgaaat  gacagtcct  gtgaagaac  attttacac  ggccaaggg  gctccccag  1080
gagtggcag  cagtccagc  gatggcatg  agtagagcc  ggcatgcca  ctccaacca  1140
tctgaagaa  tctgagaag  ctggtttca  cagcccctc  ccttcgcag  cctcctccc  1200
cggaacagc  ttcacacag  atcaccgac  tgtcataac  ggaccgaga  caagcccac  1260
tgcgacgcc  tcgactctc  actttccaa  gtcacctat  atccagcag  ctgggcctt  1320
tttctcaca  ccagccatc  gttaccacc  tcaggagac  ctgaaggag  ttgtccaac  1380
tgtctgccc  gatgctggt  agcaagctg  acaggtggg  ttcctcaat  ccaatggaa  1440
cagtcaagg  aaggtgcac  acccattcc  ccccacccc  atgttgccg  cgccaccgc  1500
accaccgat  gccaggcct  tgcctctgc  catgccaga  accaagcct  caaccacat  1560
aacagaagg  ggtgcagcc  cccccacct  accgatcct  gtacctggg  taaaagttg  1620
agcgtccca  catcctcca  acagaccac  tgacccctt  tcaactctg  aacatggac  1680
caacctcaa  ccggcgcag  tacaacttc  ctgtcagtg  aaggggaga  acaccaact  1740
gaatcaact  gtacatgga  acagcgaac  tcgtggtca  acagcaaag  cccataact  1800
ttcgggatt  ttttttttt  ttaatactt  agggactgt  gaattctct  aatatggtg  1860
tggaaatgc  ttgggctgt  tgacatttg  agtgttcca  tggtggtgt  agcagtagg  1920
gaagcggct  gtaggggat  agccttgct  acgaacttc  tgttgtaac  cttttgagc  1980
tggcctttt  acagtattt  aagaatttg  ccgcgcagg  gtgtgaccc  cccggagca  2040
ttggagaca  ctggagaat  aaatctttc  tagtagcta  gatctgtga  ctgtaactt  2100
caggacact  aagggcaat  tttttgggg  tttcttttt  ttctgtaac  tattagaaa  2160
agcaatgca  ttaagttat  tttctttta  tttggtttg  ttcagcagt  agcagttaa  2220
tacataaca  aaccctcaa  gacagtgaa  ccactcatg  tgcagagca  tccaaaaag  2280
cagcaaaga  tactactac  actctcagt  cggttgttt  ttttttttt  ttttttttt  2340
tttttttat  aagttttga  atgctgcac  tacatttaa  aaaaacatt  tcaacaatt  2400
caacaatga  acaaaagtt  acatggaaa  ggggaagat  gtctgtttt  acagaaact  2460
acaggaatc  aaacaatcg  attttgaat  gagtgaagt  caatttcat  ggatagcta  2520
gtatctttg  aagatagag  ttgttgaaa  ttctatttt  gtttttcaa  tcctcccac  2580
ccaggactc  aaattattg  ggttaaaaa  aaacagcct  gcaagaaaa  ggggagcta  2640
ttttgcttt  tatgttttt  attgttaaa  ttgtatccc  ttaaaaaaa  aaaccgaag  2700
aaaatttaa  aaaaaagca  aaaaaaaaa  tacaaatct  atggtgctt  tacctccaa  2760
atgttaact  cattaaatg  taattaatt  ttttctgtt  tcaaagcac  taactcaaa  2820
gaaatcatg  tatctgtta  ttttataag  tagaaatca  tataatgaa  tatgccaat  2880
ctggaaaat  ttacacatg  atggcaaca  cagatctat  ggttttcaa  cgcctcgtc  2940
taaccagac  ttgtccaga  gtttcaaag  cccttcgca  accctgaat  ggctacggg  3000
aatatatca  atcgataag  acataactg  gtgagccat  cagatcaaa  tacttgtta  3060
gaaaataaa  aaacaaaca  aaacaaaat  ttcacacac  cacacaccc  aaatgtctt  3120
tatcttatg  ttaaggaaa  agaaaagac  aaacggcac  agggtctga  caccatgac  3180
acctacagc  acaaggacc  aagctgaga  aggcgtctc  ttcactcgt  accttctgg  3240
ggcaccgag  aggctgctc  cttgcacag  tggttg  3276



<210> 10144
<211> 509
<212> PRT
<213> Rattus norvegicus
<308> P09414
<400> 10144

Met Tyr Ser Pro Leu Cys Leu Thr Gln Asp Glu Phe His Pro Phe Ile 
  1               5                  10                  15
Glu Ala Leu Leu Pro His Val Arg Ala Phe Ala Tyr Thr Trp Phe Asn 
             20                  25                  30
Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg Met 
         35                  40                  45
Ser Lys Glu Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Ser Glu Lys 
     50                  55                  60
Pro Glu Val Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu Arg 
 65                  70                  75                  80
Lys Asp Ile Arg Pro Glu Tyr Arg Glu Asp Phe Val Leu Thr Val Thr 
                 85                  90                  95
Gly Lys Lys Pro Pro Cys Cys Val Leu Ser Asn Pro Asp Gln Lys Gly 
             100                105                110
Lys Met Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp Arg 
         115                120                125
Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu Ser 
     130                135                140
Thr Asp Gly Glu Arg Leu Val Lys Ser Pro Gln Cys Ser Asn Pro Gly 
 145                150                155                160
Leu Cys Val Gln Pro His His Ile Gly Val Ser Val Lys Glu Leu Asp 
                 165                170                175
Leu Tyr Leu Ala Tyr Phe Val His Ala Ala Asp Ser Ser Gln Ser Glu 
             180                185                190
Ser Pro Ser Gln Pro Ser Asp Ala Asp Ile Lys Asp Gln Pro Glu Asn 
         195                200                205
Gly His Leu Gly Phe Gln Asp Ser Phe Val Thr Ser Gly Val Phe Ser 
     210                215                220
Val Thr Glu Leu Val Arg Val Ser Gln Thr Pro Ile Ala Ala Gly Thr 
 225                230                235                240
Gly Pro Asn Phe Ser Leu Ser Asp Leu Glu Ser Ser Ser Tyr Tyr Ser 
                 245                250                255
Met Ser Pro Gly Ala Met Arg Arg Ser Leu Pro Ser Thr Ser Ser Thr 
             260                265                270
Ser Ser Thr Lys Arg Leu Lys Ser Val Glu Asp Glu Met Asp Ser Pro 
         275                280                285
Gly Glu Glu Pro Phe Tyr Thr Gly Gln Gly Arg Ser Pro Gly Ser Gly 
     290                295                300
Ser Gln Ser Ser Gly Trp His Glu Val Glu Pro Gly Met Pro Ser Pro 
 305                310                315                320
Thr Thr Leu Lys Lys Ser Glu Lys Ser Gly Phe Ser Ser Pro Ser Pro 
                 325                330                335
Ser Gln Thr Ser Ser Leu Gly Thr Ala Phe Thr Gln His His Arg Pro 
             340                345                350
Val Ile Thr Gly Pro Arg Ala Ser Pro His Ala Thr Pro Ser Thr Leu 
         355                360                365
His Phe Pro Thr Ser Pro Ile Ile Gln Gln Pro Gly Pro Tyr Phe Ser 
     370                375                380
His Pro Ala Ile Arg Tyr His Pro Gln Glu Thr Leu Lys Glu Phe Val 
 385                390                395                400
Gln Leu Val Cys Pro Asp Ala Gly Gln Gln Ala Gly Gln Val Gly Phe 
                 405                410                415
Leu Asn Pro Asn Gly Ser Ser Gln Gly Lys Val His Asn Pro Phe Leu 
             420                425                430
Pro Thr Pro Met Leu Pro Pro Pro Pro Pro Pro Pro Met Ala Arg Pro 
         435                440                445
Val Pro Leu Pro Met Pro Asp Thr Lys Pro Pro Thr Thr Ser Thr Glu 
     450                455                460
Gly Gly Ala Ala Ser Pro Thr Ser Pro Thr Tyr Ser Thr Pro Ser Thr 
 465                470                475                480
Ser Pro Ala Asn Arg Phe Val Ser Val Gly Pro Arg Asp Pro Ser Phe 
                 485                490                495
Val Asn Ile Pro Gln Gln Thr Gln Ser Trp Tyr Leu Gly 
             500                505



<210> 10145
<211> 502
<212> PRT
<213> Homo sapiens
<308> AAC15752
<400> 10145

Met Tyr Ser Pro Tyr Cys Leu Thr Gln Asp Glu Phe His Pro Phe Ile 
  1               5                  10                  15
Glu Ala Leu Leu Pro His Val Arg Ala Phe Ser Tyr Thr Trp Phe Asn 
             20                  25                  30
Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg Met 
         35                  40                  45
Ser Lys Asp Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Gly Glu Lys 
     50                  55                  60
Pro Glu Ile Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu Arg 
 65                  70                  75                  80
Lys Asp Ile Arg Pro Glu Phe Arg Glu Asp Phe Val Leu Thr Ile Thr 
                 85                  90                  95
Gly Lys Lys Pro Pro Cys Cys Val Leu Ser Asn Pro Asp Gln Lys Gly 
             100                105                110
Lys Ile Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp Arg 
         115                120                125
Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu Ser 
     130                135                140
Thr Asp Gly Glu Arg Leu Tyr Lys Ser Pro Gln Cys Ser Asn Pro Gly 
 145                150                155                160
Leu Cys Val Gln Pro His His Ile Gly Val Thr Ile Lys Glu Leu Asp 
                 165                170                175
Leu Tyr Leu Ala Tyr Phe Val His Thr Pro Glu Ser Gly Gln Ser Asp 
             180                185                190
Ser Ser Asn Gln Gln Gly Asp Ala Asp Ile Lys Pro Leu Pro Asn Gly 
         195                200                205
His Leu Ser Phe Gln Asp Cys Phe Val Thr Ser Gly Val Trp Asn Val 
     210                215                220
Thr Glu Leu Val Arg Val Ser Gln Thr Pro Val Ala Thr Ala Ser Gly 
 225                230                235                240
Pro Asn Phe Ser Leu Ala Asp Leu Glu Ser Pro Ser Tyr Tyr Asn Ile 
                 245                250                255
Asn Gln Val Thr Leu Gly Arg Arg Ser Ile Thr Ser Pro Pro Ser Thr 
             260                265                270
Ser Thr Thr Lys Arg Pro Lys Ser Ile Asp Asp Ser Glu Met Glu Ser 
         275                280                285
Pro Val Asp Asp Val Phe Tyr Pro Gly Thr Gly Arg Ser Pro Ala Ala 
     290                295                300
Gly Ser Ser Gln Ser Ser Gly Trp Pro Asn Asp Val Asp Ala Gly Pro 
 305                310                315                320
Ala Ser Leu Lys Lys Ser Gly Lys Leu Asp Phe Cys Ser Ala Leu Ser 
                 325                330                335
Ser Gln Gly Ser Ser Pro Arg Met Ala Phe Thr His His Pro Leu Pro 
             340                345                350
Val Leu Ala Gly Val Arg Pro Gly Ser Pro Arg Ala Thr Ala Ser Ala 
         355                360                365
Leu His Phe Pro Ser Thr Ser Ile Ile Gln Gln Ser Ser Pro Tyr Phe 
     370                375                380
Thr His Pro Thr Ile Arg Tyr His His His His Gly Gln Asp Ser Leu 
 385                390                395                400
Lys Glu Phe Val Gln Phe Val Cys Ser Asp Gly Ser Gly Gln Ala Thr 
                 405                410                415
Gly Gln Pro Asn Gly Ser Gly Gln Gly Lys Val Pro Gly Ser Phe Leu 
             420                425                430
Leu Pro Pro Pro Pro Pro Val Ala Arg Pro Val Pro Leu Pro Met Pro 
         435                440                445
Asp Ser Lys Ser Thr Ser Thr Ala Pro Asp Gly Ala Ala Leu Thr Pro 
     450                455                460
Pro Ser Pro Ser Phe Ala Thr Thr Gly Ala Ser Ser Ala Asn Arg Phe 
 465                470                475                480
Val Ser Ile Gly Pro Arg Asp Gly Asn Phe Leu Asn Ile Pro Gln Gln 
                 485                490                495
Ser Gln Ser Trp Phe Leu 
             500



<210> 10146
<211> 2448
<212> DNA
<213> Rattus norvegicus
<308> X87157
<400> 10146

ggactgacg  cctccgtct  gagatctgg  ctcctcggc  tggcccact  ctggcttcc  60
ggcccgcag  caccaccgc  tgcctcctg  acctacaag  gggaggacg  cgcgccagc  120
gctgccggc  tcccggcgt  cccatgatc  ccctgtgcc  ttcgactct  cgaggcctc  180
acagagctg  tggctccag  cttcagctg  caatgacac  gggaaagga  ctggcttct  240
ctcttcaag  tatgtcttc  tacactgcg  ctggcagga  tgttctcag  tgggacctt  300
ctccagagc  gatcaagac  aggacagag  agctcatag  acagaccaa  caggtgtac  360
acaccgtgg  gacaatcgc  ctgaaagaa  taacttatg  gaactgtct  caggtgctg  420
ctgacatag  agtgacgta  atagtggaa  ggaccatgc  ggacttccc  cagcacgtg  480
catctgaca  agaagtgcg  gctgcaagc  cagaagcag  caaaaagct  tctcgtttt  540
atattgaga  gagcatgag  gaagatgtg  ttcagagaa  tgttcattt  caagaaaca  600
gcgatttgg  gaagataaa  cctgaagcc  ggcgatact  ggaaaagtc  attaaaatg  660
gaaaaagga  tggactcca  ctttcagaa  acataagaa  tgaaatcaa  tcaatgaag  720
agagaatga  tgagctatg  attgacttc  acaagaacc  caatgagga  gacacttcc  780
ttgtattct  caaggctga  cttggtgct  ttcctgatg  cttcattga  agtttagaa  840
aaacagatg  agacaagta  aaagttacc  taaagtatc  tcactactt  cctgtcatg  900
agaaatgct  tgtccctga  actcgaagg  agatggaaa  ggcttttca  accaggtgc  960
aacaggaaa  caccgcaat  ctgcaacag  tcctcccgc  gcgagctca  gtggccaag  1020
tgctgggct  taacaccca  gctgacttt  tccttgaac  gaacactgc  aagagcacc  1080
gccgcgtgg  cgcctttct  gatgattta  gccagaaat  gaaaccctt  ggtgaggca  1140
aacgggagt  tattttgag  ctgaagaag  aggaatgtg  agagcgagg  tttgaatac  1200
acgggaaga  caatgcatg  gacctccat  actacatga  acagacaga  gagctcaag  1260
actcggtgg  ccaggagtc  cttaaggag  acttcccca  tgaggtggt  acggaaggc  1320
tgctaagca  ctaccagga  ctgctggga  tttcatttg  acaagtgcc  gatgctcat  1380
tttggaata  gagcgtttc  ctttacact  tgaaggata  agctacagg  gaggtcctg  1440
ggcagttct  cctggacct  tatccaagg  aaggaaaat  caaccatgc  gcctgcttc  1500
gtctccagc  aggctgcct  ctccctgat  gcagtcgga  gatgtctgt  gccgccctg  1560
tggtcaact  ctctcagcc  gtagcaggt  ggccctctc  cctgagaca  gatgaagtg  1620
ggacttact  ccacgagtt  ggtcacgtc  tgcatcaga  ctgtgcgca  actgacttt  1680
cacgattca  tggaacaaa  gtggaaact  actttgtag  ggtgccatc  caaatgctt  1740
aaaactggg  gtgggacgt  gattccctg  gaaaactgt  aaagcatta  aaagatgga  1800
accctatca  agacgagct  ctcgagaag  ttgttgctt  taggctggt  aacacaggt  1860
ttctgacgc  gcgccaaat  gttttgagc  aagttgacc  atctctcca  accaatgcg  1920
ctctggatg  cgcgagcga  tacgctaaa  actgcacag  aattctggg  gttgcagct  1980
cgccaggca  aaatatgcc  gctactttt  gacacttgg  aggagggta  gatggccaa  2040
attatggat  tctttggag  gaagtgttt  ccatggaca  gtttcacag  tgttttaaa  2100
aagagggga  catgaatcc  gaggttgga  tgaaataca  aaacttaat  ctgaagcct  2160
gggggtccc  ggacggcat  gacatgctc  agaatttct  gcaacgtga  ccaaaccaa  2220
aagcattcc  aatgagtcg  ggcctgaat  gttcgtaag  cagggatcc  gggagttgt  2280
catgtctgg  ggacaagtc  acactgtca  gtggtgccg  cctggagac  gaagagagt  2340
ttacaaaag  aaacttaga  ttctattga  ttgcttttg  tttttaatt  taaaaatta  2400
acagatgta  atggaatta  aaatactgt  acctaagga  agaccaac  2448



<210> 10147
<211> 704
<212> PRT
<213> Rattus norvegicus
<308> P42676
<400> 10147

Met Ile Thr Leu Cys Leu Ser Thr Leu Arg Gly Leu His Arg Ala Gly 
  1               5                  10                  15
Gly Ser Arg Leu Gln Leu Thr Met Thr Leu Gly Lys Glu Leu Ala Ser 
             20                  25                  30
Pro Leu Gln Ala Met Ser Ser Tyr Thr Ala Ala Gly Arg Asn Val Leu 
         35                  40                  45
Arg Trp Asp Leu Ser Pro Glu Gln Ile Lys Thr Arg Thr Glu Gln Leu 
     50                  55                  60
Ile Ala Gln Thr Lys Gln Val Tyr Asp Thr Val Gly Thr Ile Ala Leu 
 65                  70                  75                  80
Lys Glu Val Thr Tyr Glu Asn Cys Leu Gln Val Leu Ala Asp Ile Glu 
                 85                  90                  95
Val Thr Tyr Ile Val Glu Arg Thr Met Leu Asp Phe Pro Gln His Val 
             100                105                110
Ser Ser Asp Arg Glu Val Arg Ala Ala Ser Thr Glu Ala Asp Lys Lys 
         115                120                125
Leu Ser Arg Phe Asp Ile Glu Met Ser Met Arg Glu Asp Val Phe Gln 
     130                135                140
Arg Ile Val His Leu Gln Glu Thr Cys Asp Leu Glu Lys Ile Lys Pro 
 145                150                155                160
Glu Ala Arg Arg Tyr Leu Glu Lys Ser Ile Lys Met Gly Lys Arg Asn 
                 165                170                175
Gly Leu His Leu Ser Glu His Ile Arg Asn Glu Ile Lys Ser Met Lys 
             180                185                190
Lys Arg Met Ser Glu Leu Cys Ile Asp Phe Asn Lys Asn Leu Asn Glu 
         195                200                205
Asp Asp Thr Ser Leu Val Phe Ser Lys Ala Glu Leu Gly Ala Leu Pro 
     210                215                220
Asp Asp Phe Ile Asp Ser Leu Glu Lys Thr Asp Glu Asp Lys Tyr Lys 
 225                230                235                240
Val Thr Leu Lys Tyr Pro His Tyr Phe Pro Val Met Lys Lys Cys Cys 
                 245                250                255
Val Pro Glu Thr Arg Arg Lys Met Glu Met Ala Phe His Thr Arg Cys 
             260                265                270
Lys Gln Glu Asn Thr Ala Ile Leu Gln Gln Leu Leu Pro Leu Arg Ala 
         275                280                285
Gln Val Ala Lys Leu Leu Gly Tyr Asn Thr His Ala Asp Phe Val Leu 
     290                295                300
Glu Leu Asn Thr Ala Lys Ser Thr Ser Arg Val Ala Ala Phe Leu Asp 
 305                310                315                320
Asp Leu Ser Gln Lys Leu Lys Pro Leu Gly Glu Ala Glu Arg Glu Phe 
                 325                330                335
Ile Leu Ser Leu Lys Lys Lys Glu Cys Glu Glu Arg Gly Phe Glu Tyr 
             340                345                350
Asp Gly Lys Ile Asn Ala Trp Asp Leu His Tyr Tyr Met Thr Gln Thr 
         355                360                365
Glu Glu Leu Lys Tyr Ser Val Asp Gln Glu Ser Leu Lys Glu Tyr Phe 
     370                375                380
Pro Ile Glu Val Val Thr Glu Gly Leu Leu Ser Ile Tyr Gln Glu Leu 
 385                390                395                400
Leu Gly Leu Ser Phe Glu Gln Val Pro Asp Ala His Val Trp Asn Lys 
                 405                410                415
Ser Val Ser Leu Tyr Thr Val Lys Asp Lys Ala Thr Gly Glu Val Leu 
             420                425                430
Gly Gln Phe Tyr Leu Asp Leu Tyr Pro Arg Glu Gly Lys Tyr Asn His 
         435                440                445
Ala Ala Cys Phe Gly Leu Gln Pro Gly Cys Leu Leu Pro Asp Gly Ser 
     450                455                460
Arg Met Met Ser Val Ala Ala Leu Val Val Asn Phe Ser Gln Pro Val 
 465                470                475                480
Ala Gly Arg Pro Ser Leu Leu Arg His Asp Glu Val Arg Thr Tyr Phe 
                 485                490                495
His Glu Phe Gly His Val Met His Gln Ile Cys Ala Gln Thr Asp Phe 
             500                505                510
Ala Arg Phe Ser Gly Thr Asn Val Glu Thr Asp Phe Val Glu Val Pro 
         515                520                525
Ser Gln Met Leu Glu Asn Trp Val Trp Asp Val Asp Ser Leu Arg Lys 
     530                535                540
Leu Ser Lys His Tyr Lys Asp Gly His Pro Ile Thr Asp Glu Leu Leu 
 545                550                555                560
Glu Lys Leu Val Ala Ser Arg Leu Val Asn Thr Gly Leu Leu Thr Leu 
                 565                570                575
Arg Gln Ile Val Leu Ser Lys Val Asp Gln Ser Leu His Thr Asn Ala 
             580                585                590
Thr Leu Asp Ala Ala Ser Glu Tyr Ala Lys Tyr Cys Thr Glu Ile Leu 
         595                600                605
Gly Val Ala Ala Thr Pro Gly Thr Asn Met Pro Ala Thr Phe Gly His 
     610                615                620
Leu Ala Gly Gly Tyr Asp Gly Gln Tyr Tyr Gly Tyr Leu Trp Ser Glu 
 625                630                635                640
Val Phe Ser Met Asp Met Phe His Ser Cys Phe Lys Lys Glu Gly Ile 
                 645                650                655
Met Asn Pro Glu Val Gly Met Lys Tyr Arg Asn Leu Ile Leu Lys Pro 
             660                665                670
Gly Gly Ser Leu Asp Gly Met Asp Met Leu Gln Asn Phe Leu Gln Arg 
         675                680                685
Glu Pro Asn Gln Lys Ala Phe Leu Met Ser Arg Gly Leu Asn Gly Ser 
     690                695                700



<210> 10148
<211> 2890
<212> DNA
<213> Homo sapiens
<308> NM_020726
<400> 10148

ggcacgagg  tggcctctg  ggctaggcc  gctcgagac  cccgggcgc  gaggcgctg  60
cgcccgcct  gccgcccca  gccgaagga  cacgcgccc  ccgccgcca  cctctcagc  120
ctcccatga  cgcccggtg  cttttggct  tgcgaagcc  ccgcagagt  ggtggttcc  180
ggattttac  cagaatgac  ttaggaaga  aagtgatgt  tcctcttca  gcaatgtct  240
cctatactg  ggctggcag  aatgtttta  gatgggatc  ttcaccaga  caaattaaa  300
caagaactg  ggagctcat  gtgcagacc  aacaggtgt  cgatgctgt  ggaatgctc  360
gtattgagg  agtaactta  gagaactgt  tgcaggcac  ggcagatgt  gaagtaaag  420
atatagtgg  aaggaccat  ctagacttt  cccagcatg  atcctctga  aaagaagta  480
gagcagcaa  tacagaagc  gacaaaaga  tttctcgtt  tgatattga  atgagcatg  540
gaggagata  atttgagag  attgttcat  tacaggaaa  ctgtgatct  gggaagata  600
aacctgagg  cagacgata  ttggaaaag  caattaaaa  ggggaaaag  aatgggctc  660
atcttcctg  acaagtaca  aatgaaatc  aatcaatga  gaaaagaat  agtgagcta  720
gtattgatt  taacaaaaa  ctcaatgag  atgatacct  ccttgtatt  tccaaggct  780
aacttggtg  tcttcctga  gatttcatt  acagtttag  aaagacaga  gatgacaag  840
ataaaatta  cttaaaata  ccacactat  tccctgtca  gaagaaatg  tgtatccct  900
aaaccagaa  aaggatgga  atggctttt  atacaaggt  caaagagga  aacaccata  960
ttttgcagc  gctactccc  ctgcgaacc  aggtggcca  actactcgg  tatagcaca  1020
atgctgact  cgtccttga  atgaacact  caaagagca  aagccgcgt  acagccttt  1080
tagatgatt  aagccagaa  ttaaaaccc  tgggtgaag  agaacgaga  tttattttg  1140
atttgaaga  aaaggaatg  aaagacagg  gttttgaat  tgatgggaa  atcaatgcc  1200
gggatctat  ttactacat  actcagaca  aggaactca  gtattccat  gaccaagag  1260
tcctcaagg  atacttccc  attgaggtg  tcactgaag  cttgctgaa  acctaccag  1320
agttgttgg  actttcatt  gaacaaatg  cagatgctc  tgtttggaa  aagagtgtt  1380
cactttata  tgtgaagga  aaagctaca  gagaagtat  gggacagtt  tatttggac  1440
tctatccaa  ggaaggaaa  tacaatcat  cggcctgct  cggtctcca  cctggctgc  1500
ttctgcctg  tggaagccg  atgatggca  tggctgccc  cgtggtgaa  ttctcacag  1560
cagtggcag  tcgtccctc  ctcctgaga  acgacgagg  gaggactta  tttcatgag  1620
ttggtcacg  gatgcatca  atttgtgca  agactgatt  tgcacgatt  agcggaaca  1680
atgtggaaa  tgactttgt  gaggtgcca  cgcaaatgc  tgaaaattg  gtgtgggac  1740
tcgattccc  ccgaagatt  tcaaaacat  ataaagatg  aagccctat  gcagacgat  1800
tgcttgaaa  acttgttgc  tctaggctg  tcaacacag  tcttctgac  ctgcgccag  1860
ttgttttga  caaagttga  cagtctctt  ataccaaca  atcgctgga  gctgcaagt  1920
aatatgcca  atactgctc  gaaatatta  gagttgcag  tactccagg  acaaatatg  1980
cagctacct  tggacattt  gcaggggga  acgatggcc  atattatgg  tatctttgg  2040
gtgaagtat  ttccatgga  atgttttac  gctgtttta  aaaagaagg  ataatgaat  2100
cagaggttg  aatgaaata  agaaaccta  tcctgaaac  tgggggatc  ctggacggc  2160
tggacatgc  ccacaattt  ttgaaacgt  agccaaacc  aaaagcgtt  ctaatgagt  2220
gaggcctgc  tgctccgtg  actggggat  tttggtagc  gtccatgtc  ggaggacaa  2280
tcgacatca  catgtgtta  tggcctgga  actgaaggg  gttttgcaa  tgaaaattt  2340
gatttctat  gacatcctt  tgttttcta  ttttaaaaa  tataaagat  taaatggaa  2400
tataaatac  gtgacctaa  aaaagaccc  ctagaaagt  attgtacta  aaaatttca  2460
aaaactgga  ttgatttct  tttatgaaa  tttcatatg  atgtaactt  attttttac  2520
attataatc  agataatat  atataagag  gctaagaat  tttaaattg  atcatatat  2580
tgatataat  tgatccttc  tgtatcttg  agttttgta  ttgggattt  tggactgat  2640
aatgaatca  cacattctt  tggtaaata  tttcttgga  ctctgtgtc  actttgatc  2700
tttgtctcc  aggaaggtg  gacctctcc  ttgcctgca  acctcaagg  caggggaat  2760
tgcctcagt  atgcattta  ctttgtata  caggccgca  gattcccaa  tttctgcca  2820
acttaaatt  cgttcctcc  tttcagttt  gtcttttct  tctaaagtt  agtcaaaga  2880
tatcaaaaaa  2890



<210> 10149
<211> 704
<212> PRT
<213> Homo sapiens
<308> Q9BYT8
<400> 10149

Met Ile Ala Arg Cys Leu Leu Ala Val Arg Ser Leu Arg Arg Val Gly 
  1               5                  10                  15
Gly Ser Arg Ile Leu Leu Arg Met Thr Leu Gly Arg Glu Val Met Ser 
             20                  25                  30
Pro Leu Gln Ala Met Ser Ser Tyr Thr Val Ala Gly Arg Asn Val Leu 
         35                  40                  45
Arg Trp Asp Leu Ser Pro Glu Gln Ile Lys Thr Arg Thr Glu Glu Leu 
     50                  55                  60
Ile Val Gln Thr Lys Gln Val Tyr Asp Ala Val Gly Met Leu Gly Ile 
 65                  70                  75                  80
Glu Glu Val Thr Tyr Glu Asn Cys Leu Gln Ala Leu Ala Asp Val Glu 
                 85                  90                  95
Val Lys Tyr Ile Val Glu Arg Thr Met Leu Asp Phe Pro Gln His Val 
             100                105                110
Ser Ser Asp Lys Glu Val Arg Ala Ala Ser Thr Glu Ala Asp Lys Arg 
         115                120                125
Leu Ser Arg Phe Asp Ile Glu Met Ser Met Arg Gly Asp Ile Phe Glu 
     130                135                140
Arg Ile Val His Leu Gln Glu Thr Cys Asp Leu Gly Lys Ile Lys Pro 
 145                150                155                160
Glu Ala Arg Arg Tyr Leu Glu Lys Ser Ile Lys Met Gly Lys Arg Asn 
                 165                170                175
Gly Leu His Leu Pro Glu Gln Val Gln Asn Glu Ile Lys Ser Met Lys 
             180                185                190
Lys Arg Met Ser Glu Leu Cys Ile Asp Phe Asn Lys Asn Leu Asn Glu 
         195                200                205
Asp Asp Thr Phe Leu Val Phe Ser Lys Ala Glu Leu Gly Ala Leu Pro 
     210                215                220
Asp Asp Phe Ile Asp Ser Leu Glu Lys Thr Asp Asp Asp Lys Tyr Lys 
 225                230                235                240
Ile Thr Leu Lys Tyr Pro His Tyr Phe Pro Val Met Lys Lys Cys Cys 
                 245                250                255
Ile Pro Glu Thr Arg Arg Arg Met Glu Met Ala Phe Asn Thr Arg Cys 
             260                265                270
Lys Glu Glu Asn Thr Ile Ile Leu Gln Gln Leu Leu Pro Leu Arg Thr 
         275                280                285
Lys Val Ala Lys Leu Leu Gly Tyr Ser Thr His Ala Asp Phe Val Leu 
     290                295                300
Glu Met Asn Thr Ala Lys Ser Thr Ser Arg Val Thr Ala Phe Leu Asp 
 305                310                315                320
Asp Leu Ser Gln Lys Leu Lys Pro Leu Gly Glu Ala Glu Arg Glu Phe 
                 325                330                335
Ile Leu Asn Leu Lys Lys Lys Glu Cys Lys Asp Arg Gly Phe Glu Tyr 
             340                345                350
Asp Gly Lys Ile Asn Ala Trp Asp Leu Tyr Tyr Tyr Met Thr Gln Thr 
         355                360                365
Glu Glu Leu Lys Tyr Ser Ile Asp Gln Glu Phe Leu Lys Glu Tyr Phe 
     370                375                380
Pro Ile Glu Val Val Thr Glu Gly Leu Leu Asn Thr Tyr Gln Glu Leu 
 385                390                395                400
Leu Gly Leu Ser Phe Glu Gln Met Thr Asp Ala His Val Trp Asn Lys 
                 405                410                415
Ser Val Thr Leu Tyr Thr Val Lys Asp Lys Ala Thr Gly Glu Val Leu 
             420                425                430
Gly Gln Phe Tyr Leu Asp Leu Tyr Pro Arg Glu Gly Lys Tyr Asn His 
         435                440                445
Ala Ala Cys Phe Gly Leu Gln Pro Gly Cys Leu Leu Pro Asp Gly Ser 
     450                455                460
Arg Met Met Ala Val Ala Ala Leu Val Val Asn Phe Ser Gln Pro Val 
 465                470                475                480
Ala Gly Arg Pro Ser Leu Leu Arg His Asp Glu Val Arg Thr Tyr Phe 
                 485                490                495
His Glu Phe Gly His Val Met His Gln Ile Cys Ala Gln Thr Asp Phe 
             500                505                510
Ala Arg Phe Ser Gly Thr Asn Val Glu Thr Asp Phe Val Glu Val Pro 
         515                520                525
Ser Gln Met Leu Glu Asn Trp Val Trp Asp Val Asp Ser Leu Arg Arg 
     530                535                540
Leu Ser Lys His Tyr Lys Asp Gly Ser Pro Ile Ala Asp Asp Leu Leu 
 545                550                555                560
Glu Lys Leu Val Ala Ser Arg Leu Val Asn Thr Gly Leu Leu Thr Leu 
                 565                570                575
Arg Gln Ile Val Leu Ser Lys Val Asp Gln Ser Leu His Thr Asn Thr 
             580                585                590
Ser Leu Asp Ala Ala Ser Glu Tyr Ala Lys Tyr Cys Ser Glu Ile Leu 
         595                600                605
Gly Val Ala Ala Thr Pro Gly Thr Asn Met Pro Ala Thr Phe Gly His 
     610                615                620
Leu Ala Gly Gly Tyr Asp Gly Gln Tyr Tyr Gly Tyr Leu Trp Ser Glu 
 625                630                635                640
Val Phe Ser Met Asp Met Phe Tyr Ser Cys Phe Lys Lys Glu Gly Ile 
                 645                650                655
Met Asn Pro Glu Val Gly Met Lys Tyr Arg Asn Leu Ile Leu Lys Pro 
             660                665                670
Gly Gly Ser Leu Asp Gly Met Asp Met Leu His Asn Phe Leu Lys Arg 
         675                680                685
Glu Pro Asn Gln Lys Ala Phe Leu Met Ser Arg Gly Leu His Ala Pro 
     690                695                700



<210> 10150
<211> 1794
<212> DNA
<213> Rattus norvegicus
<308> X87885
<400> 10150

gtttaactt  cagggggcc  tggaaccca  gcagattga  gtagatccg  aggaagatc  60
ccagaacgc  cctgatgtc  actacgtgg  ggagaaccc  accctggat  tggagcagt  120
tgcagccag  tacagtggt  tgatgcgta  tgagcggct  cagtttatt  ctgaccgct  180
ccctccgtt  cgagtggag  ccttgaaaa  ggctctgtc  ttcgtgcag  ggaccttca  240
tgtggacat  tatgaagag  tacaccgga  gctctctga  gctaccagg  agctgcaga  300
tgcacctga  gccatccct  agagtggag  ggagccccc  cccctggac  cagcctggg  360
ggaggccac  cggaagaag  ccctgttga  actggagaa  ttagacacg  acttgaaga  420
ctacaaggg  aattctatc  aggagagca  caggcgcgg  catgatgac  tgggtgacc  480
ctacctgga  tgtggggac  tcagcaatg  cctcaagtg  tattcgcga  cccgagact  540
ctgcaccag  gctaagcat  tcatcaaca  gtgcctcaa  gtcatcaag  tcagtgtct  600
cttgcagaa  tggtctcat  tgttaagct  tgtcagcaa  gctgagtct  ctccagaga  660
tgctgagca  cggggagag  gggacagcc  gactcaagc  atcctcacc  agctcaagt  720
tgctgcagg  ttggctgag  tggctgcac  aaagtataa  caagctgcc  agtgcttcc  780
tctggcttc  tttgatcac  gtgatttcc  agagctgct  tcccccagc  atgtggctg  840
ctatggtgg  ctatgtgcc  tagccacct  tgaccggca  gagctgcaa  gcaatgtca  900
ctccagcag  tccttcaag  tgttcctgg  gctggagcc  caggtcaga  acatcatct  960
caaatttta  gagtccaag  atgcctcat  cttgaagat  ttggacgag  tgaaggaca  1020
cctgctcct  gacatgtac  tggcccctc  cgtcaggac  ctgtatacc  agatccgta  1080
ccgggctct  atccaatac  tcagcccct  tgtgtcagc  gatatgcac  agatggctg  1140
tgccttcaa  acaacagtt  cagctctgg  ggatgagct  acacaggtc  tcctggagg  1200
ccttattaa  gcccgcatc  actcacaca  caagatact  tatgctcga  acgtggatc  1260
gcgtagcac  acctttgag  agtccctgc  gatgggcaa  gagttccaa  gacgggcca  1320
agccatgat  ctgagagca  ctgtgctac  caaccagat  catgtcaag  ctcctccta  1380
agaagggag  caaggggag  tgactccag  aaacagcca  tcacggatg  gcaccaaca  1440
gtgaaaggc  ttcccgtga  cttcagact  gtctgcaca  ctcctctgc  agtggaagc  1500
gcacctggg  ctcctgcct  ctttcctca  gatgagacc  cagactgtg  ggttcatta  1560
agcagtcca  cccctggga  gccagttca  tggccttcc  cttcggagg  cccctctgc  1620
gtggtaggc  ggctgccca  tatggccat  cgggcctga  tctaggttt  tgtcccaat  1680
aaacagacc  tgtgcaatt  ccaggtaag  gttcctcaa  ccttcctgt  catgtagtt  1740
tgactgcag  agtgtcact  accaagtag  ccattaaag  acagattga  catt  1794



<210> 10151
<211> 471
<212> PRT
<213> Rattus norvegicus
<308> P97834
<400> 10151

Met Gln Ile Asp Val Asp Pro Gln Glu Asp Pro Gln Asn Ala Pro Asp 
  1               5                  10                  15
Val Asn Tyr Val Val Glu Asn Pro Thr Leu Asp Leu Glu Gln Tyr Ala 
             20                  25                  30
Ala Ser Tyr Ser Gly Leu Met Arg Ile Glu Arg Leu Gln Phe Ile Ala 
         35                  40                  45
Asp Arg Cys Pro Pro Leu Arg Val Glu Ala Leu Lys Met Ala Leu Ser 
     50                  55                  60
Phe Val Gln Arg Thr Phe Asn Val Asp Met Tyr Glu Glu Ile His Arg 
 65                  70                  75                  80
Lys Leu Ser Glu Ala Thr Arg Glu Leu Gln Asn Ala Pro Asp Ala Ile 
                 85                  90                  95
Pro Glu Ser Gly Val Glu Pro Pro Pro Leu Asp Thr Ala Trp Val Glu 
             100                105                110
Ala Thr Arg Lys Lys Ala Leu Leu Lys Leu Glu Lys Leu Asp Thr Asp 
         115                120                125
Leu Lys Asn Tyr Lys Gly Asn Ser Ile Lys Glu Ser Ile Arg Arg Gly 
     130                135                140
His Asp Asp Leu Gly Asp His Tyr Leu Asp Cys Gly Asp Leu Ser Asn 
 145                150                155                160
Ala Leu Lys Cys Tyr Ser Arg Ala Arg Asp Tyr Cys Thr Ser Ala Lys 
                 165                170                175
His Val Ile Asn Met Cys Leu Asn Val Ile Lys Val Ser Val Tyr Leu 
             180                185                190
Gln Asn Trp Ser His Val Leu Ser Tyr Val Ser Lys Ala Glu Ser Thr 
         195                200                205
Pro Glu Ile Ala Glu Gln Arg Gly Glu Arg Asp Ser Gln Thr Gln Ala 
     210                215                220
Ile Leu Thr Lys Leu Lys Cys Ala Ala Gly Leu Ala Glu Leu Ala Ala 
 225                230                235                240
Arg Lys Tyr Lys Gln Ala Ala Lys Cys Phe Leu Leu Ala Ser Phe Asp 
                 245                250                255
His Cys Asp Phe Pro Glu Leu Leu Ser Pro Ser Asn Val Ala Val Tyr 
             260                265                270
Gly Gly Leu Cys Ala Leu Ala Thr Phe Asp Arg Gln Glu Leu Gln Arg 
         275                280                285
Asn Val Ile Ser Ser Ser Ser Phe Lys Leu Phe Leu Glu Leu Glu Pro 
     290                295                300
Gln Val Arg Asp Ile Ile Phe Lys Phe Tyr Glu Ser Lys Tyr Ala Ser 
 305                310                315                320
Cys Leu Lys Met Leu Asp Glu Met Lys Asp Asn Leu Leu Leu Asp Met 
                 325                330                335
Tyr Leu Ala Pro His Val Arg Thr Leu Tyr Thr Gln Ile Arg Asn Arg 
             340                345                350
Ala Leu Ile Gln Tyr Phe Ser Pro Tyr Val Ser Ala Asp Met His Lys 
         355                360                365
Met Ala Ala Ala Phe Asn Thr Thr Val Ala Ala Leu Glu Asp Glu Leu 
     370                375                380
Thr Gln Val Ile Leu Glu Gly Leu Ile Asn Ala Arg Ile Asp Ser His 
 385                390                395                400
Ser Lys Ile Leu Tyr Ala Arg Asp Val Asp Gln Arg Ser Thr Thr Phe 
                 405                410                415
Glu Lys Ser Leu Leu Met Gly Lys Glu Phe Gln Arg Arg Ala Lys Ala 
             420                425                430
Met Ile Leu Arg Ala Ala Val Leu Arg Asn Gln Ile His Val Lys Ser 
         435                440                445
Pro Pro Arg Glu Gly Ser Gln Gly Glu Leu Thr Pro Ala Asn Ser Gln 
     450                455                460
Ser Arg Met Ser Thr Asn Met 
 465                470



<210> 10152
<211> 1866
<212> DNA
<213> Homo sapiens
<308> NM_004127
<400> 10152

tctctgaag  tccagaatc  atggaagtg  acggcacgc  gcggcgggg  gggtgcaag  60
tgccgctgc  ggttcaggt  tttaacttg  agggggccg  ggagcccat  cagatcgac  120
tggaccccc  ggaagaccc  cagaatgca  ctgacgtca  ctacgtggt  gagaacccc  180
gcctggatc  ggaacagta  gcggccagc  acagcggcc  gatgcgcat  gaacggctg  240
agttcattg  tgatcactg  cccacgctg  gggtggagg  cctgaagat  gccctctcc  300
tcgtgcaga  aacctttaa  gtggacatg  acgaggaga  ccaccgcaa  ctctcagag  360
ccaccaggg  gctgcagaa  gcacccgac  ccatccctg  gagcggcgt  gagccccca  420
ccctggaca  ggcctgggt  gaggccacg  ggaagaagg  gctgctgaa  ctggagaag  480
tggacacag  cctgaagaa  tacaagggc  actccatca  agagagcat  cggcgcggc  540
acgacgacc  gggcgacca  tacctggac  gtggggacc  cagcaacgc  ctcaagtgc  600
attcccggg  ccgggacta  tgcaccagc  ccaaacacg  catcaacat  tgcctcaat  660
tcatcaagg  cagcgtcta  ttgcagaat  ggtctcatg  gctcagcta  gtcagcaag  720
ctgagtcca  cccagagat  gccgagcag  gaggagagc  tgacagcca  acccaggcc  780
tcctcacca  gctcaagtg  gccgcaggc  tggcagagc  ggccgccag  aagtacaag  840
aggctgcca  gtgcctcct  ctggcttcc  ttgatcact  tgacttccc  gagctgctg  900
cccccagca  cgtggccat  tacggtggc  tgtgcgcct  ggctacctt  gaccggcag  960
agctgcagc  caatgtcat  tccagcagc  ccttcaagt  gttcttgga  ctggagcca  1020
aggtccgag  catcatctt  aaattctac  agtccaagt  cgcctcatg  ctcaagatg  1080
tggacgaga  gaaggacaa  ctgctcctg  acatgtatc  ggcccccca  gtcaggacc  1140
tgtacaccc  gattcgcaa  cgtgccctc  tccagtatt  cagccccta  gtgtcagcc  1200
acatgcata  gatggcggc  gccttcaat  ccacggtgg  cgccctgga  gacgagctg  1260
cgcagctaa  cctggaggg  ctgatcagt  cccgtgtgg  ctcacacag  aagatccta  1320
acgcccggg  cgtggatca  cgcagcacc  cctttgaga  gtctctgtt  atgggcaag  1380
agttccagc  ccgcgccaa  gccatgatg  tgcgggcag  tgtgctccg  aaccagatc  1440
atgtcaagt  cccgcccag  gaagggagc  agggggagc  gactccagc  aacagccag  1500
cccggatga  caccaacat  tgaggggtg  accttggcc  ccaggacat  tgcaccccc  1560
ccccacctc  acggacctc  gacctccag  cggctcagt  ctgcctgcg  cccagctaa  1620
gggcctggc  actgggtgc  acccagcct  tgtgccctc  ctggggctg  ggaggcagg  1680
ggctgctag  tgtggccct  cctggaagg  gaggcctgc  gggctcgac  ctgtgggtt  1740
ctgtcccca  ggagcagac  gtgcggcac  caggcccag  ggcaccatt  cccagaccc  1800
tcctgttcc  gcctcagtc  ggtgcagac  agtgggcgg  gtccattaa  gagcagact  1860
agcgtt  1866



<210> 10153
<211> 471
<212> PRT
<213> Homo sapiens
<308> Q13098
<400> 10153

Met Gln Ile Asp Val Asp Pro Gln Glu Asp Pro Gln Asn Ala Pro Asp 
  1               5                  10                  15
Val Asn Tyr Val Val Glu Asn Pro Ser Leu Asp Leu Glu Gln Tyr Ala 
             20                  25                  30
Ala Ser Tyr Ser Gly Leu Met Arg Ile Glu Arg Leu Gln Phe Ile Ala 
         35                  40                  45
Asp His Cys Pro Thr Leu Arg Val Glu Ala Leu Lys Met Ala Leu Ser 
     50                  55                  60
Phe Val Gln Arg Thr Phe Asn Val Asp Met Tyr Glu Glu Ile His Arg 
 65                  70                  75                  80
Lys Leu Ser Glu Ala Thr Arg Glu Leu Gln Asn Ala Pro Asp Ala Ile 
                 85                  90                  95
Pro Glu Ser Gly Val Glu Pro Pro Ala Leu Asp Thr Ala Trp Val Glu 
             100                105                110
Ala Thr Arg Lys Lys Ala Leu Leu Lys Leu Glu Lys Leu Asp Thr Asp 
         115                120                125
Leu Lys Asn Tyr Lys Gly Asn Ser Ile Lys Glu Ser Ile Arg Arg Gly 
     130                135                140
His Asp Asp Leu Gly Asp His Tyr Leu Asp Cys Gly Asp Leu Ser Asn 
 145                150                155                160
Ala Leu Lys Cys Tyr Ser Arg Ala Arg Asp Tyr Cys Thr Ser Ala Lys 
                 165                170                175
His Val Ile Asn Met Cys Leu Asn Val Ile Lys Val Ser Val Tyr Leu 
             180                185                190
Gln Asn Trp Ser His Val Leu Ser Tyr Val Ser Lys Ala Glu Ser Thr 
         195                200                205
Pro Glu Ile Ala Glu Gln Arg Gly Glu Arg Asp Ser Gln Thr Gln Ala 
     210                215                220
Ile Leu Thr Lys Leu Lys Cys Ala Ala Gly Leu Ala Glu Leu Ala Ala 
 225                230                235                240
Arg Lys Tyr Lys Gln Ala Ala Lys Cys Leu Leu Leu Ala Ser Phe Asp 
                 245                250                255
His Cys Asp Phe Pro Glu Leu Leu Ser Pro Ser Asn Val Ala Ile Tyr 
             260                265                270
Gly Gly Leu Cys Ala Leu Ala Thr Phe Asp Arg Gln Glu Leu Gln Arg 
         275                280                285
Asn Val Ile Ser Ser Ser Ser Phe Lys Leu Phe Leu Glu Leu Glu Pro 
     290                295                300
Gln Val Arg Asp Ile Ile Phe Lys Phe Tyr Glu Ser Lys Tyr Ala Ser 
 305                310                315                320
Cys Leu Lys Met Leu Asp Glu Met Lys Asp Asn Leu Leu Leu Asp Met 
                 325                330                335
Tyr Leu Ala Pro His Val Arg Thr Leu Tyr Thr Gln Ile Arg Asn Arg 
             340                345                350
Ala Leu Ile Gln Tyr Phe Ser Pro Tyr Val Ser Ala Asp Met His Arg 
         355                360                365
Met Ala Ala Ala Phe Asn Thr Thr Val Ala Ala Leu Glu Asp Glu Leu 
     370                375                380
Thr Gln Leu Ile Leu Glu Gly Leu Ile Ser Ala Arg Val Asp Ser His 
 385                390                395                400
Ser Lys Ile Leu Tyr Ala Arg Asp Val Asp Gln Arg Ser Thr Thr Phe 
                 405                410                415
Glu Lys Ser Leu Leu Met Gly Lys Glu Phe Gln Arg Arg Ala Lys Ala 
             420                425                430
Met Met Leu Arg Ala Ala Val Leu Arg Asn Gln Ile His Val Lys Ser 
         435                440                445
Pro Pro Arg Glu Gly Ser Gln Gly Glu Leu Thr Pro Ala Asn Ser Gln 
     450                455                460
Ser Arg Met Ser Thr Asn Met 
 465                470



<210> 10154
<211> 469
<212> DNA
<213> Rattus norvegicus
<308> X89697
<400> 10154

tgtgtgtcg  ccactacac  acaccagca  tatgcaccc  cttctctgc  acacattgg  60
catctcctc  tgggtggga  gccttgtga  ctctctgac  cagacaagc  tcatcatga  120
catacctct  tgtggccat  acctgaacc  cttctactg  gagatgctt  ttctcctga  180
gctggcttg  gaggacaca  ggggaacag  ggccaactt  tttgtggca  gggctataa  240
tttggtctg  cctgtagca  taattctag  cacctatgc  cacattgcc  atgcggtgc  300
gaagatcaa  tcaagagct  ggcgcagaa  ggctctggg  acttgtggg  cccacctta  360
tgtggtttc  ctcttttat  gctcagcca  gtacacgta  ctccaacct  tccacatgt  420
ttctgggag  gaaggaaag  tcgctgccc  cttttatac  atagttact  469



<210> 10155
<211> 154
<212> PRT
<213> Rattus norvegicus
<308> CAA61844
<400> 10155

Val Cys Arg Pro Leu His Tyr Thr Ser Ile Met His Pro Leu Leu Cys 
  1               5                  10                  15
His Thr Leu Ala Ile Ser Ser Trp Val Gly Gly Leu Val Asn Ser Leu 
             20                  25                  30
Thr Gln Thr Ser Leu Ile Met Thr Ile Pro Leu Cys Gly His His Leu 
         35                  40                  45
Asn His Phe Tyr Cys Glu Met Leu Val Leu Leu Lys Leu Ala Cys Glu 
     50                  55                  60
Asp Thr Gly Gly Thr Glu Ala Asn Leu Phe Val Ala Gly Ala Ile Ile 
 65                  70                  75                  80
Leu Val Cys Pro Val Ala Leu Ile Leu Gly Thr Tyr Ala His Ile Ala 
                 85                  90                  95
His Ala Val Leu Lys Ile Lys Ser Arg Ala Gly Arg Arg Lys Ala Leu 
             100                105                110
Gly Thr Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr Gly Ser 
         115                120                125
Ala Met Tyr Thr Tyr Leu Gln Pro Val His Met Tyr Ser Gly Ser Glu 
     130                135                140
Gly Lys Phe Ala Ala Leu Phe Tyr Thr Ile 
 145                150



<210> 10156
<211> 647
<212> DNA
<213> Homo sapiens
<308> AF399629
<400> 10156

ctcctggac  tctgcttca  caccagcac  gtgccccag  tcctgatca  cctttgcgg  60
gtggaccgc  ccatcaccc  tggagggtg  gtggctcag  tcttcatct  cctagccct  120
ggctccaca  agtgtgtgc  cctggtggt  atggccttt  accgctatg  tgctgtctg  180
cgtccactc  actacatgg  catcatgca  ccccatctc  gccagaccc  ggctatcgc  240
tcctggggt  cgggtttcg  gaactctct  atccagaca  gtctcgcaa  ggccatgcc  300
ctctgtggc  atcgactga  tcacttctt  tgtgagatg  ctgtatttc  gaagttggc  360
tgtgcggac  cagaaggaa  agaggccaa  atgtttgtg  cccgagtca  agtcgtggc  420
gttcctgca  cacttattc  aggctccta  gtgcacatt  ctcatgcag  gctgagggt  480
aagtcaacg  ctgggcgca  aaaggcttt  gggacttgt  ggtcccacc  cctagtagt  540
ttccttttt  atggctcag  catctacac  tatctccaa  ccatccaca  ttattctga  600
cgtgaggga  aatttgttg  cctttttta  actataatt  cccccat  647



<210> 10157
<211> 215
<212> PRT
<213> Homo sapiens
<308> AAK95114
<400> 10157

Leu Leu Asp Leu Cys Phe Thr Thr Ser Thr Val Pro Gln Leu Leu Ile 
  1               5                  10                  15
Asn Leu Cys Gly Val Asp Arg Thr Ile Thr Arg Gly Gly Cys Val Ala 
             20                  25                  30
Gln Leu Phe Ile Tyr Leu Ala Leu Gly Ser Thr Glu Cys Val Leu Leu 
         35                  40                  45
Val Val Met Ala Phe Asp Arg Tyr Ala Ala Val Cys Arg Pro Leu His 
     50                  55                  60
Tyr Met Ala Ile Met His Pro His Leu Cys Gln Thr Leu Ala Ile Ala 
 65                  70                  75                  80
Ser Trp Gly Ala Gly Phe Val Asn Ser Leu Ile Gln Thr Gly Leu Ala 
                 85                  90                  95
Met Ala Met Pro Leu Cys Gly His Arg Leu Asn His Phe Phe Cys Glu 
             100                105                110
Met Pro Val Phe Leu Lys Leu Ala Cys Ala Asp Thr Glu Gly Thr Glu 
         115                120                125
Ala Lys Met Phe Val Ala Arg Val Ile Val Val Ala Val Pro Ala Ala 
     130                135                140
Leu Ile Leu Gly Ser Tyr Val His Ile Ala His Ala Val Leu Arg Val 
 145                150                155                160
Lys Ser Thr Ala Gly Arg Arg Lys Ala Phe Gly Thr Cys Gly Ser His 
                 165                170                175
Leu Leu Val Val Phe Leu Phe Tyr Gly Ser Ala Ile Tyr Thr Tyr Leu 
             180                185                190
Gln Ser Ile His Asn Tyr Ser Glu Arg Glu Gly Lys Phe Val Ala Leu 
         195                200                205
Phe Tyr Thr Ile Ile Thr Pro 
     210                215



<210> 10158
<211> 430
<212> DNA
<213> Rattus norvegicus
<308> X89698
<400> 10158

tatctgcaa  cctctttac  atacaacta  tatgagtag  cccatatgt  accgcctgg  60
ggctggttc  tgggtgggg  gattttttc  ttctattat  cagattttc  tcactatcc  120
tttgccttt  tgtggtccc  atattattg  ccactactt  tgtgacctc  atcccttat  180
caagttggc  tgcactgac  cttttgtgg  aggggtaat  atgtttgtt  acagtggat  240
attttctgt  ttttccttc  ttttcttgg  gtcttctta  attgttatc  tatataact  300
gaggaatca  tctgctgag  ggaggcgca  ggctctatc  acctgtgca  ctcacatca  360
ggtggttgt  ttgttcttc  gacctgcca  cttcctcta  ttgagacct  cttccacct  420
cactgaagac  430



<210> 10159
<211> 143
<212> PRT
<213> Rattus norvegicus
<308> CAA61845
<400> 10159

Ile Cys Lys Pro Leu Tyr Tyr Thr Thr Ile Met Ser Arg Pro Ile Cys 
  1               5                  10                  15
His Arg Leu Val Ala Gly Ser Trp Val Gly Gly Phe Phe His Ser Ile 
             20                  25                  30
Ile Gln Ile Phe Ile Thr Ile Pro Leu Pro Phe Cys Gly Pro Asn Ile 
         35                  40                  45
Ile Asp His Tyr Phe Cys Asp Leu His Pro Leu Phe Lys Leu Ala Cys 
     50                  55                  60
Thr Asp Thr Phe Val Val Gly Val Ile Met Phe Val Asn Ser Gly Leu 
 65                  70                  75                  80
Phe Ser Val Phe Ser Phe Leu Phe Leu Val Ser Ser Tyr Ile Val Ile 
                 85                  90                  95
Leu Tyr Asn Leu Arg Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu 
             100                105                110
Ser Thr Cys Ala Ser His Ile Met Val Val Val Leu Phe Phe Gly Pro 
         115                120                125
Ala Ile Phe Leu Tyr Leu Arg Pro Ala Ser Thr Tyr Thr Glu Asp 
     130                135                140



<210> 10160
<211> 641
<212> DNA
<213> Homo sapiens
<308> AF399579
<400> 10160

ttggtggag  tcagttatt  ctccactat  gcccctaaa  tcatcatag  cttacttgc  60
aagattaaa  ccatctctc  ggaaggctg  ctgactcag  tattcttct  ccacttctt  120
ggggttgct  agatccttt  gattgtggt  atggcctat  attgctacg  ggccatttg  180
aagcctctt  attatatga  cattatcag  cgtcaactg  gtcaccttc  ggtggctgg  240
tcctggctg  ggggctttt  tcactccat  attcagatt  tcgttatca  ccaattgcc  300
ttctgtggt  ccaatgtga  tgaccacta  ttctgtgac  tccagcctt  attcaagct  360
gcctgcact  acaccttca  ggagggggt  attgtgttg  ccaacagtg  attattctc  420
gtcttctcc  tcctcatct  ggtgtcctc  tatattgtc  ttctggtca  cttgaggaa  480
cattctgca  aggggaggc  caaagccct  tccacctgt  cttctcaca  cacagtggt  540
atcttgttt  ttggacctg  tatcttcct  tacatgcga  cttcttcca  tttcactga  600
gataaactt  tggctgtat  ctacacggt  atcaccccc  t  641



<210> 10161
<211> 213
<212> PRT
<213> Homo sapiens
<308> AAK95064
<400> 10161

Leu Val Glu Ile Ser Tyr Ser Ser Thr Ile Ala Pro Lys Phe Ile Ile 
  1               5                  10                  15
Asp Leu Leu Ala Lys Ile Lys Thr Ile Ser Leu Glu Gly Cys Leu Thr 
             20                  25                  30
Gln Ile Phe Phe Phe His Phe Phe Gly Val Ala Glu Ile Leu Leu Ile 
         35                  40                  45
Val Val Met Ala Tyr Asp Cys Tyr Val Ala Ile Cys Lys Pro Leu His 
     50                  55                  60
Tyr Met Asn Ile Ile Ser Arg Gln Leu Cys His Leu Leu Val Ala Gly 
 65                  70                  75                  80
Ser Trp Leu Gly Gly Phe Cys His Ser Ile Ile Gln Ile Leu Val Ile 
                 85                  90                  95
Ile Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe Cys 
             100                105                110
Asp Leu Gln Pro Leu Phe Lys Leu Ala Cys Thr Asp Thr Phe Met Glu 
         115                120                125
Gly Val Ile Val Leu Ala Asn Ser Gly Leu Phe Ser Val Phe Ser Phe 
     130                135                140
Leu Ile Leu Val Ser Ser Tyr Ile Val Ile Leu Val Asn Leu Arg Asn 
 145                150                155                160
His Ser Ala Glu Gly Arg His Lys Ala Leu Ser Thr Cys Ala Ser His 
                 165                170                175
Ile Thr Val Val Ile Leu Phe Phe Gly Pro Ala Ile Phe Leu Tyr Met 
             180                185                190
Arg Pro Ser Ser Thr Phe Thr Glu Asp Lys Leu Val Ala Val Phe Tyr 
         195                200                205
Thr Val Ile Thr Pro 
     210



<210> 10162
<211> 472
<212> DNA
<213> Rattus norvegicus
<308> X89703
<400> 10162

aatctgtaa  cctttacta  acaaggcta  catggtacc  aggatctgt  gtcttctga  60
atttgtttc  tatttgata  ggtttgttt  tgccatgat  ctcacaggc  taatgttta  120
gctcaaatt  tgtaatatc  gcatcatca  tcactacat  tgtgacatc  tccctgtca  180
tcggatctc  tgcagtaac  cctatgtca  tgaacttgt  agctctgct  tggtgggta  240
aggtatcat  ttatgtagc  tccttatct  aatctctta  gctatgatc  tttccaata  300
cctttatat  tcttcaggt  agggttggt  caaagcctt  ggcacttgt  gttctcaca  360
cataactgt  agtttcttc  atggatctg  gctgcttgc  tatgtaaag  catcttctg  420
tgagactgt  ggccaggga  aaatttttt  agtgtttta  acatttctg  tg  472



<210> 10163
<211> 157
<212> PRT
<213> Rattus norvegicus
<308> CAA61850
<400> 10163

Ile Cys Lys Pro Leu Leu Tyr Lys Ala Ile Met Val Pro Arg Ile Cys 
  1               5                  10                  15
Cys Leu Leu Ile Phe Val Ser Tyr Leu Ile Gly Phe Val Cys Ala Met 
             20                  25                  30
Ile Leu Thr Gly Leu Met Phe Arg Leu Lys Phe Cys Asn Ile Ser Ile 
         35                  40                  45
Ile Asn His Tyr Met Cys Asp Ile Phe Pro Val Ile Arg Ile Ser Cys 
     50                  55                  60
Ser Asn Thr Tyr Val Asn Glu Leu Val Ser Ser Ala Val Val Gly Thr 
 65                  70                  75                  80
Gly Ile Ile Leu Cys Ser Leu Leu Ile Leu Ile Ser Tyr Ala Met Ile 
                 85                  90                  95
Leu Ser Asn Ile Leu Tyr Met Ser Ser Gly Lys Gly Trp Ser Lys Ala 
             100                105                110
Leu Gly Thr Cys Gly Ser His Ile Ile Thr Val Ser Phe Phe Tyr Gly 
         115                120                125
Ser Gly Leu Leu Ala Tyr Val Lys Pro Ser Ser Ala Glu Thr Val Gly 
     130                135                140
Gln Gly Lys Ile Phe Ser Val Phe Tyr Thr Phe Leu Val 
 145                150                155



<210> 10164
<211> 472
<212> DNA
<213> Homo sapiens
<308> X89675
<400> 10164

catctgtaa  ccactgttg  acatggtca  catgtctcc  caggtgtgt  ttctccttt  60
gttgggtgt  tatgggatg  ggtttgctg  ggccatggc  cacacagcg  gcatgatgg  120
tgtgacctt  tgtgccaat  accttgtca  ccactacat  tgtgacatc  ttccccttc  180
tgagtgtgc  tgcaccagc  cctatgtga  tgagcttgt  gtgtttgtt  ttgtgagca  240
tgatattgg  gtgcccaca  tcactatct  catttccta  gctctcatt  tctccagca  300
cttccacat  gattccacg  agggcaggt  caaagcctt  agcacctgc  gctcccaca  360
aattgcagt  tctctgttc  ttgggtcag  agcattcat  tacctcaaa  ccttttctc  420
tttagctat  aaccagggc  aggtgtctt  cctattcta  accactgtg  tg  472



<210> 10165
<211> 311
<212> PRT
<213> Homo sapiens
<308> CAA61822
<400> 10165

Met Ala Ala Glu Asn Ser Ser Phe Val Thr Gln Phe Ile Leu Ala Gly 
  1               5                  10                  15
Leu Thr Asp Gln Pro Gly Val Gln Ile Pro Leu Phe Phe Leu Phe Leu 
             20                  25                  30
Gly Phe Tyr Val Val Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu 
         35                  40                  45
Ile Arg Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Tyr 
     50                  55                  60
Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Ser Val Ile Thr Pro Lys 
 65                  70                  75                  80
Met Leu Met Ser Phe Val Leu Lys Lys Asn Ser Ile Ser Tyr Ala Gly 
                 85                  90                  95
Cys Met Thr Gln Leu Phe Phe Phe Leu Phe Phe Val Val Ser Glu Ser 
             100                105                110
Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 
         115                120                125
Pro Leu Leu Tyr Met Val Thr Met Ser Pro Gln Val Cys Phe Leu Leu 
     130                135                140
Leu Leu Gly Val Tyr Gly Met Gly Phe Ala Gly Ala Met Ala His Thr 
 145                150                155                160
Ala Cys Met Met Gly Val Thr Phe Cys Ala Asn Asn Leu Val Asn His 
                 165                170                175
Tyr Met Cys Asp Ile Leu Pro Leu Leu Glu Cys Ala Cys Thr Ser Thr 
             180                185                190
Tyr Val Asn Glu Leu Val Val Phe Val Val Val Gly Ile Asp Ile Gly 
         195                200                205
Val Pro Thr Val Thr Ile Phe Ile Ser Tyr Ala Leu Ile Leu Ser Ser 
     210                215                220
Ile Phe His Ile Asp Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 
 225                230                235                240
Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser Gly Ala 
                 245                250                255
Phe Met Tyr Leu Lys Pro Phe Ser Leu Leu Ala Met Asn Gln Gly Lys 
             260                265                270
Val Ser Ser Leu Phe Tyr Thr Thr Val Val Pro Met Leu Asn Pro Leu 
         275                280                285
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Lys Lys Ile 
     290                295                300
Leu Asn Lys Asn Ala Phe Ser 
 305                310



<210> 10166
<211> 2924
<212> DNA
<213> Rattus norvegicus
<308> X91810
<400> 10166

atggctcag  ggaaccagc  ccagcagct  gacacgcgc  acctggagc  gcttcatca  60
ctgtacagc  atagcttcc  catggagct  cggcagttc  tggcgcctt  gattgagag  120
caagattgg  catatgcag  cagcaaaga  tcacacgcc  ctctggtgt  tcataacct  180
ttgggcgag  tcgaccagc  gtatagccg  ttcctgcag  agtccaatg  cctctatca  240
cacaacctg  gaagaatca  gcagttcct  cagagcagg  atcttgaga  gccaatgga  300
attgcccgg  ttgtggccc  atgcctgtg  gaagagtct  gcctcctcc  gacggcagc  360
acggcagcc  agcaagggg  ccaggccaa  caccccaca  ctgccgtag  gacggagaa  420
cagcagatg  tggaacagc  tcttcagga  gtccggaag  gtgtgcagg  tctagaaca  480
aaaatgaaa  tggtggaga  tctccagga  gactttgat  tcaactata  aaccctcaa  540
agtcaagga  acatgcagg  tctgaatgg  aacaaccag  ctgtgacca  acagaagat  600
cagcagctg  agcagatgc  cacggccct  gaccagatg  ggaggagca  cgtgagcga  660
ctggcaggg  tcttgtcag  aatggagta  gtgcagaag  cactgaccg  tgaagagct  720
gctgactgg  agaggcggc  gcagatagc  tgcatcgga  gccctccca  catctgcct  780
gaccgtctg  aaaactgga  aacttcatt  gcagaatct  aacttcaga  ccgccaaca  840
attaagaaa  tggaggagc  gcagcagaa  gtgtcctac  agggggacc  tattgtgca  900
caccggcca  tgctggagg  gaggatcgt  gatctgttc  gaaacttaa  gaagagtgc  960
ttcgtggtg  agcggcagc  ctgtatgcc  atgcacccg  accggccct  agtcatcaa  1020
actggtgtc  agtttacca  aaaagtcag  ttgctggtc  aatttcctg  gttgaatta  1080
cagcttaaa  ttaaagtgt  cattgataa  gactctggg  atgtcgctg  cctcagagg  1140
tctcggaaa  ttaacattc  gggcacgaa  acaaaggtg  tgaacatgg  ggagtccaa  1200
aacggtagc  tgtctgcag  gttcaagca  ctgaccctg  gggagcaga  atgtgggaa  1260
gggggccgt  ccaattgtg  tgcctcctt  attgtcact  aggagctgc  cctgatcac  1320
tttgagaca  aggtgtacc  ccaaggtct  aagatcgac  tagagaccc  ctccttgcc  1380
gtcgtggtg  tctccaaca  ctgtcagat  cctaatgct  gggcatcaa  cctgtggta  1440
aacatgctg  ccaataacc  caagaacgt  aacttcttc  ctaagcctc  gattggaac  1500
tgggaccaa  tggccgagg  gctgagctg  cagttctcg  ccaccacca  gcgagggct  1560
agcatcgag  agctgacca  cctggccga  aagctctta  ggcctggtg  gaactactc  1620
gggtgtcag  tcacatggg  taagttttg  aaagaaaac  tggccggca  gggcttctc  1680
ttctgggtc  ggctagaca  tatcatcga  cttgtgaaa  agtatatct  ggccctttg  1740
aatgaaggg  acatcatgg  tttcatcag  aaggagcgg  agagggcca  cctaagcac  1800
aagcccccg  gcaccttcc  gctgcggtt  agtgagagc  gcaaggaag  aggggtcac  1860
ttcacttgg  tggaaaagg  catcagtgg  aagacccag  tccagtctg  agaaccata  1920
accaagcag  agctgaaca  catgtcatt  gctgaaatc  tcatgggct  taagatcat  1980
gacgctacc  acatcctgg  atccccact  gtctacctc  accctgaca  tcccaagga  2040
gaggcattc  gaaagtatt  tcgccccga  agccaggag  accctgaag  tgacccagg  2100
agtgctgcc  cttacctga  gaccaagtt  atctgtgtg  caccaacga  ctgcagcaa  2160
accattgac  tgccgatgt  cccccgcac  ttagattca  tgatgcagt  tggaaataa  2220
ggtgaaggt  ctgagccct  agcaggagg  cagtttgag  cgctcacgt  tgacatgga  2280
ctgacctcg  agtgtgcta  ctccccgat  tgaggagct  aaaggcaaa  ctacagagt  2340
tgactgaga  actgcccat  tcaccttag  agcaactca  atcactgaa  tcactgtgt  2400
cagattttt  ctttaacct  ctacttctg  tgtctttgg  cagtctggg  actttttaa  2460
atagagaac  gagtgagcg  gggtgatgc  ctcttatgt  aggaggagg  cacctcttg  2520
gtccgtgat  gctgtgaaa  cagagggct  ggggggagc  aaaggaaac  cctatgttc  2580
gtccgcctg  cctcctggt  tgttgttga  aagcgcctc  tggtgccat  gcatcctgc  2640
gcccctttc  gtgagctga  accccaggc  gggactccc  gctctgcac  ttcaacctg  2700
ttaatgtcc  catagaagc  aggactaag  ctataggct  ctctttaag  taaaaaaaa  2760
aaaaatact  agaattaaa  ggcaaaaca  actgaaaac  gcatagcct  tccatatca  2820
agaaaactc  ggtaacagc  ttttcggtg  tttaagctg  cttaggctg  tcatttata  2880
aaactctgc  atggttcaa  caatctgta  agacagctg  gaac  2924



<210> 10167
<211> 770
<212> PRT
<213> Rattus norvegicus
<308> P52631
<400> 10167

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
  1               5                  10                  15
Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
             20                  25                  30
Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
         35                  40                  45
Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
     50                  55                  60
Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
 65                  70                  75                  80
His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                 85                  90                  95
Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
             100                105                110
Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
         115                120                125
Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
     130                135                140
Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
 145                150                155                160
Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                 165                170                175
Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
             180                185                190
Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
         195                200                205
Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
     210                215                220
Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
 225                230                235                240
Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                 245                250                255
Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
             260                265                270
Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
         275                280                285
Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
     290                295                300
Leu Glu Glu Arg Ile Val Asp Leu Phe Arg Asn Leu Met Lys Ser Ala 
 305                310                315                320
Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                 325                330                335
Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
             340                345                350
Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
         355                360                365
Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
     370                375                380
Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
 385                390                395                400
Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                 405                410                415
Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
             420                425                430
Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
         435                440                445
Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
     450                455                460
Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
 465                470                475                480
Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                 485                490                495
Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
             500                505                510
Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
         515                520                525
Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
     530                535                540
Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
 545                550                555                560
Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                 565                570                575
Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
             580                585                590
Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
         595                600                605
Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
     610                615                620
Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
 625                630                635                640
Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                 645                650                655
Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
             660                665                670
Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
         675                680                685
Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
     690                695                700
Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
 705                710                715                720
Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                 725                730                735
Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
             740                745                750
Glu Ser Leu Thr Phe Asp Met Asp Leu Thr Ser Glu Cys Ala Thr Ser 
         755                760                765
Pro Met 
     770



<210> 10168
<211> 2787
<212> DNA
<213> Homo sapiens
<308> L29277
<400> 10168

cagctggaa  tcggggcgg  ggcgcagac  gggaggggg  gccgggggt  ccgacgtcg  60
agccgaggg  acaagcccc  accggatcc  ggacaggca  cccggcttg  cgctgtctc  120
ccccctcgg  tcggagagg  ccttcggcc  gagggagcc  cgccgcccg  ccccggcac  180
cgcgcagcc  cggcctctc  gcctctgcc  gagaaacag  atggcccaa  ggaatcagc  240
acagcagct  gacacacgg  acctggagc  gctccatca  ctctacagt  acagcttcc  300
aatggagct  cggcagttt  tggcccctt  gattgagag  caagattgg  catatgcgg  360
cagcaaaga  tcacatgcc  ctttggtgt  tcataatct  ctgggagag  ttgaccagc  420
gtatagccg  ttcctgcaa  agtcgaatg  tctctatca  cacaatcta  gaagaatca  480
gcagtttct  cagagcagg  atcttgaga  gccaatgga  attgcccgg  ttgtggccc  540
gtgcctgtg  gaagaatca  gccttctac  gactgcagc  actgcggcc  agcaagggg  600
ccaggccaa  caccccaca  cagccgtgg  gacggagaa  cagcagatg  tggagcagc  660
ccttcagga  gtccggaag  gagtgcagg  tctagaaca  aaaatgaaa  tggtagaga  720
tctccagga  gactttgat  tcaactata  aaccctcaa  agtcaagga  acatgcaag  780
tctgaatgg  aacaaccag  cagtgacca  gcagaagat  cagcagctg  aacagatgc  840
cactgcgct  gaccagatg  ggagaagca  cgtgagtga  ctggcgggg  ttttgtcag  900
gatggagta  gtgcagaaa  ctctcacgg  cgaggagct  gctgactgg  agaggcggc  960
acagattgc  tgcattgga  gcccgccca  catctgcct  gatcggcta  aaaactgga  1020
aacgtcatt  gcagaatct  aacttcaga  ccgtcaaca  attaagaaa  tggaggagt  1080
gcaccaaaa  gtttcctac  aaggggacc  cattgtaca  caccggccg  tgctggagg  1140
gaggatcgt  gagctgttc  gaaacttaa  gaaaagtgc  tttgtggtg  agcggcagc  1200
ctgcatgcc  atgcatcct  accggcccc  cgtcatcaa  accggcgtc  agttcacta  1260
taaagtcag  ttgctggtc  agttccctg  gttgaatta  cagcttaaa  ttaaagtgt  1320
cattgacaa  gactctggg  acgttgcag  tctcagagg  tcccggaaa  ttaacattc  1380
gggcacaaa  acaaaagtg  tgaacatgg  agaatccaa  aacggcagc  tctctgcag  1440
attcaaaca  ttgaccctg  gggagcaga  atgtgggaa  gggggccga  ccaattgtg  1500
tgcttccct  attgtgact  aggagctgc  cctgatcac  tttgagacc  aggtgtatc  1560
ccaaggtct  aagattgac  tagagaccc  ctccttgtc  gttgtggtg  tctccaaca  1620
ctgtcagat  ccaaatgcc  gggcgtcca  cctgtggta  aacatgctg  ccaacaatc  1680
caagaatgt  aacttcttc  ctaagccgc  aattggaac  tgggaccaa  tggccgagg  1740
gctcagctg  cagttctcg  ccaccacca  gcgggggct  agcatcgag  agctgacaa  1800
gctggctga  aagctccta  ggcctggtg  gaactactc  gggtgtcag  tcacatggg  1860
taacttctg  aaagaaaac  tggctggca  gggcttctc  tactgggtc  ggctagaca  1920
tatcatcga  cttgtgaaa  agtatatct  ggccctttg  aatgaaggg  acatcatgg  1980
tttcatcag  aaggagcgg  agcgggcca  cttgagcac  aagccccca  gcaccttcc  2040
gctgcgctt  agtgaaagc  gcaaagaag  aggcgtcac  ttcacttgg  tggagaagg  2100
catcagcgg  aagacccag  tccagtccg  ggaaccata  acaaagcag  agctgaaca  2160
catgtcatt  gctgaaatc  tcatgggct  taagatcat  gatgctacc  atatcctgt  2220
gtctccact  gtctatctc  atcctgaca  tcccaagga  gaggcattc  ggaagtatt  2280
tcggccaga  agccaggag  atcctgaag  tgacccagg  agcgctgcc  catacctga  2340
gaccaagtt  atctgtgtg  caccaacga  ctgcagcaa  accattgac  tgccgatgt  2400
cccccgcgc  ttagattca  tgatgcagt  tggaaataa  ggtgaaggt  ctgaaccct  2460
agcaggagg  cagtttgag  ccctcacct  tgacatgga  ttgacctcg  agtgcgcta  2520
ctcccccat  tgaggagct  agaacggaa  ctgcagaaa  atacgactg  ggcgcctac  2580
tgcattctg  cacccctca  acagccaaa  cccagatca  ctgaaacta  taactttgt  2640
gttccagat  ttttttaat  tcctacttc  gctatcttt  agcaatctg  gcactttta  2700
aaatagaga  atgagtgaa  gtgggtgat  tgcttttat  taaatgcaa  taaggatgt  2760
ttctctgag  cccatgatc  ggggatg  2787



<210> 10169
<211> 770
<212> PRT
<213> Homo sapiens
<308> P40763
<400> 10169

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
  1               5                  10                  15
Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
             20                  25                  30
Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
         35                  40                  45
Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
     50                  55                  60
Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
 65                  70                  75                  80
His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                 85                  90                  95
Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
             100                105                110
Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
         115                120                125
Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
     130                135                140
Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
 145                150                155                160
Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                 165                170                175
Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
             180                185                190
Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
         195                200                205
Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
     210                215                220
Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
 225                230                235                240
Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                 245                250                255
Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
             260                265                270
Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu His 
         275                280                285
Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
     290                295                300
Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
 305                310                315                320
Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                 325                330                335
Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
             340                345                350
Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
         355                360                365
Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
     370                375                380
Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
 385                390                395                400
Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                 405                410                415
Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
             420                425                430
Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
         435                440                445
Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Ser Val Val Val Ile 
     450                455                460
Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
 465                470                475                480
Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                 485                490                495
Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
             500                505                510
Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
         515                520                525
Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
     530                535                540
Thr Trp Ala Asn Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
 545                550                555                560
Tyr Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                 565                570                575
Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
             580                585                590
Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
         595                600                605
Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
     610                615                620
Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
 625                630                635                640
Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                 645                650                655
Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Leu Ser Pro Leu Val Tyr 
             660                665                670
Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
         675                680                685
Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
     690                695                700
Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
 705                710                715                720
Thr Ile Asp Leu Pro Met Ser Pro Arg Ala Leu Asp Ser Leu Met Gln 
                 725                730                735
Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
             740                745                750
Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
         755                760                765
Pro Met 
     770



<210> 10170
<211> 2243
<212> DNA
<213> Rattus norvegicus
<308> X92070
<400> 10170

gggaactgg  agcatggct  ctgcagtcg  agcagcact  gtgagctgg  ggtttctgg  60
ttacaagac  gagaaatat  tgatgacca  gaactgctg  gtgggcatc  cccagaggc  120
gctgcagct  ggagtggta  tctacgtga  tgggtgggc  ctcttggcc  aaaaaggct  180
ccaggaatg  gacatggac  cccagattt  tgtcatcac  aaactcaag  gggtttctg  240
aacccaggt  aaggaactg  agaaacggc  gtgggatgt  gctgacttc  tgaggccat  300
acagggaga  aatgtgttc  tcctggtaa  caacttcct  gtgacacca  ctcaagtcc  360
gggcagatg  ccagagcat  cttctgttc  tctggctaa  tgctgggct  atgaggact  420
tcctgaagg  gagatgggg  catacagcc  cggcataaa  actggtcag  gtgtggcgt  480
caacggaac  cacaggacc  gtgagatct  gagctggtg  ccagtggag  gtagtgctg  540
gcccaggaa  cccctgcta  ctcaggcca  gaacttcac  ctcttcatc  aaaatactg  600
aaccttcaa  aagttcaac  tctccagaa  caatgcctt  gatacctgg  acaacacct  660
tttcaagta  tgtctctac  attcactct  cagtccgta  tgcccagtg  tccgcatcg  720
ggaccttgt  gctatgact  gaggggact  tgaggacct  gcattgctg  gtggtgctg  780
gggcatcaa  atccactgg  attgcaacc  ggacacgaa  ggctctgac  gctctcccc  840
gtactcctt  cagctgcag  agagggggt  caatttcag  acagctaat  actggtggg  900
agcctcagg  gtggagtcc  ggagcctgc  caaactcta  gggatccgc  ttgacattc  960
tgtcactgg  caggcagga  agtttgcac  catccctac  gccatcaca  tgggcacag  1020
agcagcttg  ctgggcatg  tcaccttcc  ctgtgatct  ctgctactg  acgtggata  1080
agaggccgg  ttctactgg  ggaccaagt  tgaagaggc  agagcccca  aggcaacta  1140
caacagtgc  tagacagag  cggctttct  acctgctaa  cctgctgcc  aggtgtctc  1200
ggagtggtt  gcacctgcc  cacgtctgc  gatgccggg  tccaagcat  catgcacca  1260
tggcctgtc  ggatggtgt  agcctatcc  ttcctgagg  atacaccct  tccctgcta  1320
ttaaagtta  ggcttggga  catcgagga  aaagcccca  aggactgga  agggggttg  1380
ggtaattcc  ccagactct  catacaaac  ccctcctag  ttcacccag  gagagagag  1440
gagagagag  gagagagag  gagagagag  gcgcaatgc  gttgaatga  tggtggctg  1500
tatccttgg  actctcttt  tgtctgctg  ggcactctg  catctagtt  aaggcccct  1560
gtcctggct  ccaggtttc  cgggagcct  aggaatgag  gaagctgca  gtctaggat  1620
tcctgttat  aaatcagtc  tggcaacct  aacctattc  gaagcacct  cctgccaga  1680
gccctgact  tggccccag  cagagtgcc  tagttttga  gtatggtct  atgaagggc  1740
ctggggttc  ttaggactg  ctggttctg  aactatcct  ccttgattc  tcccttagt  1800
agactttcc  catgaacca  agaaagaag  gcaaggaca  gctacataa  ctttcctgg  1860
ccaagtgtg  ggtggtgta  aaagtgcat  ccgggaagt  aagaggcag  ttggctgtg  1920
atgtgcagt  acggaggga  taccaaggc  agggtgaaa  caacagtca  agctgggac  1980
tccaggctt  cacggcctc  aaaaccctt  agaattcct  gtgccactc  gccctcaag  2040
ctgtagcct  aaaagggct  gagtgcaga  gcgggggtc  cggaggtgg  tcacatgga  2100
acagtagtt  tgggggtag  ggaaccaaa  aacctgata  tcctgctga  gtaaagctt  2160
ccaaagcaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  2220
aaaaaaaaa  aaaaaaaaa  aaa  2243



<210> 10171
<211> 379
<212> PRT
<213> Rattus norvegicus
<308> P51579
<400> 10171

Met Ala Ser Ala Val Ala Ala Ala Leu Val Ser Trp Gly Phe Leu Asp 
  1               5                  10                  15
Tyr Lys Thr Glu Lys Tyr Val Met Thr Arg Asn Cys Trp Val Gly Ile 
             20                  25                  30
Ser Gln Arg Leu Leu Gln Leu Gly Val Val Val Tyr Val Ile Gly Trp 
         35                  40                  45
Ala Leu Leu Ala Lys Lys Gly Tyr Gln Glu Trp Asp Met Asp Pro Gln 
     50                  55                  60
Ile Ser Val Ile Thr Lys Leu Lys Gly Val Ser Val Thr Gln Val Lys 
 65                  70                  75                  80
Glu Leu Glu Lys Arg Leu Trp Asp Val Ala Asp Phe Val Arg Pro Ser 
                 85                  90                  95
Gln Gly Glu Asn Val Phe Phe Leu Val Thr Asn Phe Leu Val Thr Pro 
             100                105                110
Ala Gln Val Gln Gly Arg Cys Pro Glu His Pro Ser Val Pro Leu Ala 
         115                120                125
Asn Cys Trp Ala Asp Glu Asp Cys Pro Glu Gly Glu Met Gly Thr Tyr 
     130                135                140
Ser His Gly Ile Lys Thr Gly Gln Cys Val Ala Phe Asn Gly Thr His 
 145                150                155                160
Arg Thr Cys Glu Ile Trp Ser Trp Cys Pro Val Glu Ser Ser Ala Val 
                 165                170                175
Pro Arg Lys Pro Leu Leu Ala Gln Ala Lys Asn Phe Thr Leu Phe Ile 
             180                185                190
Lys Asn Thr Val Thr Phe Asn Lys Phe Asn Phe Ser Arg Thr Asn Ala 
         195                200                205
Leu Asp Thr Trp Asp Asn Thr Tyr Phe Lys Tyr Cys Leu Tyr Asp Ser 
     210                215                220
Leu Ser Ser Pro Tyr Cys Pro Val Phe Arg Ile Gly Asp Leu Val Ala 
 225                230                235                240
Met Thr Gly Gly Asp Phe Glu Asp Leu Ala Leu Leu Gly Gly Ala Val 
                 245                250                255
Gly Ile Asn Ile His Trp Asp Cys Asn Leu Asp Thr Lys Gly Ser Asp 
             260                265                270
Cys Ser Pro Gln Tyr Ser Phe Gln Leu Gln Glu Arg Gly Tyr Asn Phe 
         275                280                285
Arg Thr Ala Asn Tyr Trp Trp Ala Ala Ser Gly Val Glu Ser Arg Ser 
     290                295                300
Leu Leu Lys Leu Tyr Gly Ile Arg Phe Asp Ile Leu Val Thr Gly Gln 
 305                310                315                320
Ala Gly Lys Phe Ala Leu Ile Pro Thr Ala Ile Thr Val Gly Thr Gly 
                 325                330                335
Ala Ala Trp Leu Gly Met Val Thr Phe Leu Cys Asp Leu Leu Leu Leu 
             340                345                350
Tyr Val Asp Arg Glu Ala Gly Phe Tyr Trp Arg Thr Lys Tyr Glu Glu 
         355                360                365
Ala Arg Ala Pro Lys Ala Thr Thr Asn Ser Ala 
     370                375



<210> 10172
<211> 851
<212> DNA
<213> Homo sapiens
<308> BE876713
<400> 10172

ctccccagg  gccacagca  actgggggc  tctggatta  aaaacggag  agtgggcgc  60
cctcgccaa  aaaggctac  aggagcggg  cctggaacc  cagatttcc  tcacaacca  120
actcaaagg  gtttccgtg  ctcagatca  ggagcttgg  aaccggctg  gggatgtgg  180
cgacttcgt  aagccacct  agggagaga  cgtgttctt  ttggtgacc  acttccttg  240
gacgccagc  caagttcag  gcagatgcc  agagataca  ggtcttgct  tgttgccca  300
gctggagtg  agaggctat  cacaggtat  atcaagccc  ctgcagcct  gagcctcct  360
ggctcaagc  gtcctccca  ctcagcctt  tgagtaact  agactacag  cgtgtacca  420
cattcccag  taataaagt  tatttttaa  aaatcaaaa  aaaaaaaaa  aaaaaaaaa  480
aaaaaaaaa  aaaaaaaaa  acaaaaaca  aaacaaaaa  caggggggg  acaaaaaag  540
gacccgaga  gggcacaaa  ataagagca  caacatatg  ggagacagg  gcccaaaga  600
agggcgaaa  tacgagcaa  gaaacgggc  agaaaaaac  gacccgcag  gggaaacac  660
gcccccgcg  aactatgga  gagagcccc  caccacgcg  ggagggcac  aacaagcgg  720
gaaacagca  cacgagaga  agacaaccc  caggggcca  acaaacaca  cggggcaca  780
aagcggcgc  agcagcgag  caaagcgac  cagtagaaa  aggagaaag  gaacggacg  840
aaaactcac  g  851



<210> 10173
<211> 431
<212> PRT
<213> Homo sapiens
<308> NP_005437
<400> 10173

Met Gly Ser Pro Gly Ala Thr Thr Gly Trp Gly Leu Leu Asp Tyr Lys 
  1               5                  10                  15
Thr Glu Lys Tyr Val Met Thr Arg Asn Trp Arg Val Gly Ala Leu Gln 
             20                  25                  30
Arg Leu Leu Gln Phe Gly Ile Val Val Tyr Val Val Gly Trp Ala Leu 
         35                  40                  45
Leu Ala Lys Lys Gly Tyr Gln Glu Arg Asp Leu Glu Pro Gln Phe Ser 
     50                  55                  60
Ile Ile Thr Lys Leu Lys Gly Val Ser Val Thr Gln Ile Lys Glu Leu 
 65                  70                  75                  80
Gly Asn Arg Leu Trp Asp Val Ala Asp Phe Val Lys Pro Pro Gln Gly 
                 85                  90                  95
Glu Asn Val Phe Phe Leu Val Thr Asn Phe Leu Val Thr Pro Ala Gln 
             100                105                110
Val Gln Gly Arg Cys Pro Glu His Pro Ser Val Pro Leu Ala Asn Cys 
         115                120                125
Trp Val Asp Glu Asp Cys Pro Glu Gly Glu Gly Gly Thr His Ser His 
     130                135                140
Gly Val Lys Thr Gly Gln Cys Val Val Phe Asn Gly Thr His Arg Thr 
 145                150                155                160
Cys Glu Ile Trp Ser Trp Cys Pro Val Glu Ser Gly Val Val Pro Ser 
                 165                170                175
Arg Pro Leu Leu Ala Gln Ala Gln Asn Phe Thr Leu Phe Ile Lys Asn 
             180                185                190
Thr Val Thr Phe Ser Lys Phe Asn Phe Ser Lys Ser Asn Ala Leu Glu 
         195                200                205
Thr Trp Asp Pro Thr Tyr Phe Lys His Cys Arg Tyr Glu Pro Gln Phe 
     210                215                220
Ser Pro Tyr Cys Pro Val Phe Arg Ile Gly Asp Leu Val Ala Lys Ala 
 225                230                235                240
Gly Gly Thr Phe Glu Asp Leu Ala Leu Leu Gly Gly Ser Val Gly Ile 
                 245                250                255
Arg Val His Trp Asp Cys Asp Leu Asp Thr Gly Asp Ser Gly Cys Trp 
             260                265                270
Pro His Tyr Ser Phe Gln Leu Gln Glu Lys Ser Tyr Asn Phe Arg Thr 
         275                280                285
Ala Thr His Trp Trp Glu Gln Pro Gly Val Glu Ala Arg Thr Leu Leu 
     290                295                300
Lys Leu Tyr Gly Ile Arg Phe Asp Ile Leu Val Thr Gly Gln Ala Gly 
 305                310                315                320
Lys Phe Gly Leu Ile Pro Thr Ala Val Thr Leu Gly Thr Gly Ala Ala 
                 325                330                335
Trp Leu Gly Val Val Thr Phe Phe Cys Asp Leu Leu Leu Leu Tyr Val 
             340                345                350
Asp Arg Glu Ala His Phe Tyr Trp Arg Thr Lys Tyr Glu Glu Ala Lys 
         355                360                365
Ala Pro Lys Ala Thr Ala Asn Ser Val Trp Arg Glu Leu Ala Leu Ala 
     370                375                380
Ser Gln Ala Arg Leu Ala Glu Cys Leu Arg Arg Ser Ser Ala Pro Ala 
 385                390                395                400
Pro Thr Ala Thr Ala Ala Gly Ser Gln Thr Gln Thr Pro Gly Trp Pro 
                 405                410                415
Cys Pro Ser Ser Asp Thr His Leu Pro Thr His Ser Gly Ser Leu 
             420                425                430



<210> 10174
<211> 716
<212> DNA
<213> Rattus norvegicus
<308> X92097
<400> 10174

agcggcttc  cctcgtccg  accatggtg  ctctcgcag  actgctggt  ctgctggcc  60
cgctgctgg  cacggcctc  ggctacttc  tcagcatcg  cgcgcacgc  gaggagtgc  120
tcttcgagc  ggtcacctc  ggcaccaag  tgggcctca  cttcgaggt  gcggagggc  180
gcttcctgg  catcgacgt  gagatcaca  gaccagata  taaaggaat  tataaagga  240
accgggagt  cagcgggaa  tacacgttt  cagcccaca  ggatgggac  tacaagttc  300
gctttagta  taggatgtc  actatgact  caaagatag  gatgttcac  attgacatt  360
gggaggctc  taaaggaca  gacatggag  cagaagctc  tcaaaacaa  ctagaagaa  420
tgattaatg  gctggcagt  gccatgaca  ccgtaaagc  cgaacagga  tacatggaa  480
tccgggaga  aatacacag  gccatcaac  acaacacaa  cagcagagt  gtcctttgg  540
ccttcttcg  agctcttgt  cttgttgcc  tgacattgg  acagatcta  tacctgaag  600
gattttttg  agtccggag  gttgtttaa  aggcctttt  ctattgatc  caaattcat  660
atttacttg  ttaccaaac  ccttggtca  aataatgtc  ttagtttat  catttt  716



<210> 10175
<211> 201
<212> PRT
<213> Rattus norvegicus
<308> Q63524
<400> 10175

Met Val Thr Leu Ala Glu Leu Leu Val Leu Leu Ala Ala Leu Leu Ala 
  1               5                  10                  15
Thr Ala Ser Gly Tyr Phe Val Ser Ile Asp Ala His Ala Glu Glu Cys 
             20                  25                  30
Phe Phe Glu Arg Val Thr Ser Gly Thr Lys Met Gly Leu Ile Phe Glu 
         35                  40                  45
Val Ala Glu Gly Gly Phe Leu Asp Ile Asp Val Glu Ile Thr Gly Pro 
     50                  55                  60
Asp Asn Lys Gly Ile Tyr Lys Gly Asp Arg Glu Ser Ser Gly Lys Tyr 
 65                  70                  75                  80
Thr Phe Ala Ala His Met Asp Gly Thr Tyr Lys Phe Cys Phe Ser Asn 
                 85                  90                  95
Arg Met Ser Thr Met Thr Pro Lys Ile Val Met Phe Thr Ile Asp Ile 
             100                105                110
Gly Glu Ala Pro Lys Gly Gln Asp Met Glu Thr Glu Ala His Gln Asn 
         115                120                125
Lys Leu Glu Glu Met Ile Asn Glu Leu Ala Val Ala Met Thr Ala Val 
     130                135                140
Lys His Glu Gln Glu Tyr Met Glu Val Arg Glu Arg Ile His Arg Ala 
 145                150                155                160
Ile Asn Asp Asn Thr Asn Ser Arg Val Val Leu Trp Ser Phe Phe Glu 
                 165                170                175
Ala Leu Val Leu Val Ala Met Thr Leu Gly Gln Ile Tyr Tyr Leu Lys 
             180                185                190
Arg Phe Phe Glu Val Arg Arg Val Val 
         195                200



<210> 10176
<211> 684
<212> DNA
<213> Homo sapiens
<308> BG255482
<400> 10176

cgatgacag  tgtaaagca  gaacaggaa  acatggaag  ccgggagag  atacacaga  60
ccatcaacg  caacacaaa  agcagagtg  tcctttggt  cttctttga  gctcttgtt  120
tagttgcca  gacattggg  cagatctac  acctgaaga  attttttga  gtccggaga  180
ttgtttaaa  agcctcttc  tgatgatcc  aactcagaa  tcactgttt  ccaaacacc  240
tggtcataa  aatgtcatt  gtttctcca  ttttatttt  tgaactgta  attcacaac  300
tatgtttct  tgagattaa  agatatggg  gaaaaacgc  tttttagga  aattatagt  360
aaaatttga  agttgattg  cataatttc  tgtttgaat  ctgcctcca  tatataggt  420
cttccagga  ctcaaacac  gtaagtgaa  tatgggagt  tagttttta  tatttcttc  480
tttcctttt  ttttcataa  ataatgcag  ttgttcagg  aatcagcac  aagcctgat  540
gtactttac  aaaatgact  cattctttg  attccttca  tctatggtt  aagtcacta  600
agattcatt  tgttgagtc  ttatgagaa  cagcagtat  aatcttgac  gtttctgcc  660
gtcctaatg  cagagctct  tgac  684



<210> 10177
<211> 201
<212> PRT
<213> Homo sapiens
<308> Q15363
<400> 10177

Met Val Thr Leu Ala Glu Leu Leu Val Leu Leu Ala Ala Leu Leu Ala 
  1               5                  10                  15
Thr Val Ser Gly Tyr Phe Val Ser Ile Asp Ala His Ala Glu Glu Cys 
             20                  25                  30
Phe Phe Glu Arg Val Thr Ser Gly Thr Lys Met Gly Leu Ile Phe Glu 
         35                  40                  45
Val Ala Glu Gly Gly Phe Leu Asp Ile Asp Val Glu Ile Thr Gly Pro 
     50                  55                  60
Asp Asn Lys Gly Ile Tyr Lys Gly Asp Arg Glu Ser Ser Gly Lys Tyr 
 65                  70                  75                  80
Thr Phe Ala Ala His Met Asp Gly Thr Tyr Lys Phe Cys Phe Ser Asn 
                 85                  90                  95
Arg Met Ser Thr Met Thr Pro Lys Ile Val Met Phe Thr Ile Asp Ile 
             100                105                110
Gly Glu Ala Pro Lys Gly Gln Asp Met Glu Thr Glu Ala His Gln Asn 
         115                120                125
Lys Leu Glu Glu Met Ile Asn Glu Leu Ala Val Ala Met Thr Ala Val 
     130                135                140
Lys His Glu Gln Glu Tyr Met Glu Val Arg Glu Arg Ile His Arg Ala 
 145                150                155                160
Ile Asn Asp Asn Thr Asn Ser Arg Val Val Leu Trp Ser Phe Phe Glu 
                 165                170                175
Ala Leu Val Leu Val Ala Met Thr Leu Gly Gln Ile Tyr Tyr Leu Lys 
             180                185                190
Arg Phe Phe Glu Val Arg Arg Val Val 
         195                200



<210> 10178
<211> 716
<212> DNA
<213> Rattus norvegicus
<308> X92097
<400> 10178

agcggcttc  cctcgtccg  accatggtg  ctctcgcag  actgctggt  ctgctggcc  60
cgctgctgg  cacggcctc  ggctacttc  tcagcatcg  cgcgcacgc  gaggagtgc  120
tcttcgagc  ggtcacctc  ggcaccaag  tgggcctca  cttcgaggt  gcggagggc  180
gcttcctgg  catcgacgt  gagatcaca  gaccagata  taaaggaat  tataaagga  240
accgggagt  cagcgggaa  tacacgttt  cagcccaca  ggatgggac  tacaagttc  300
gctttagta  taggatgtc  actatgact  caaagatag  gatgttcac  attgacatt  360
gggaggctc  taaaggaca  gacatggag  cagaagctc  tcaaaacaa  ctagaagaa  420
tgattaatg  gctggcagt  gccatgaca  ccgtaaagc  cgaacagga  tacatggaa  480
tccgggaga  aatacacag  gccatcaac  acaacacaa  cagcagagt  gtcctttgg  540
ccttcttcg  agctcttgt  cttgttgcc  tgacattgg  acagatcta  tacctgaag  600
gattttttg  agtccggag  gttgtttaa  aggcctttt  ctattgatc  caaattcat  660
atttacttg  ttaccaaac  ccttggtca  aataatgtc  ttagtttat  catttt  716



<210> 10179
<211> 201
<212> PRT
<213> Rattus norvegicus
<308> Q63524
<400> 10179

Met Val Thr Leu Ala Glu Leu Leu Val Leu Leu Ala Ala Leu Leu Ala 
  1               5                  10                  15
Thr Ala Ser Gly Tyr Phe Val Ser Ile Asp Ala His Ala Glu Glu Cys 
             20                  25                  30
Phe Phe Glu Arg Val Thr Ser Gly Thr Lys Met Gly Leu Ile Phe Glu 
         35                  40                  45
Val Ala Glu Gly Gly Phe Leu Asp Ile Asp Val Glu Ile Thr Gly Pro 
     50                  55                  60
Asp Asn Lys Gly Ile Tyr Lys Gly Asp Arg Glu Ser Ser Gly Lys Tyr 
 65                  70                  75                  80
Thr Phe Ala Ala His Met Asp Gly Thr Tyr Lys Phe Cys Phe Ser Asn 
                 85                  90                  95
Arg Met Ser Thr Met Thr Pro Lys Ile Val Met Phe Thr Ile Asp Ile 
             100                105                110
Gly Glu Ala Pro Lys Gly Gln Asp Met Glu Thr Glu Ala His Gln Asn 
         115                120                125
Lys Leu Glu Glu Met Ile Asn Glu Leu Ala Val Ala Met Thr Ala Val 
     130                135                140
Lys His Glu Gln Glu Tyr Met Glu Val Arg Glu Arg Ile His Arg Ala 
 145                150                155                160
Ile Asn Asp Asn Thr Asn Ser Arg Val Val Leu Trp Ser Phe Phe Glu 
                 165                170                175
Ala Leu Val Leu Val Ala Met Thr Leu Gly Gln Ile Tyr Tyr Leu Lys 
             180                185                190
Arg Phe Phe Glu Val Arg Arg Val Val 
         195                200



<210> 10180
<211> 684
<212> DNA
<213> Homo sapiens
<308> BG255482
<400> 10180

cgatgacag  tgtaaagca  gaacaggaa  acatggaag  ccgggagag  atacacaga  60
ccatcaacg  caacacaaa  agcagagtg  tcctttggt  cttctttga  gctcttgtt  120
tagttgcca  gacattggg  cagatctac  acctgaaga  attttttga  gtccggaga  180
ttgtttaaa  agcctcttc  tgatgatcc  aactcagaa  tcactgttt  ccaaacacc  240
tggtcataa  aatgtcatt  gtttctcca  ttttatttt  tgaactgta  attcacaac  300
tatgtttct  tgagattaa  agatatggg  gaaaaacgc  tttttagga  aattatagt  360
aaaatttga  agttgattg  cataatttc  tgtttgaat  ctgcctcca  tatataggt  420
cttccagga  ctcaaacac  gtaagtgaa  tatgggagt  tagttttta  tatttcttc  480
tttcctttt  ttttcataa  ataatgcag  ttgttcagg  aatcagcac  aagcctgat  540
gtactttac  aaaatgact  cattctttg  attccttca  tctatggtt  aagtcacta  600
agattcatt  tgttgagtc  ttatgagaa  cagcagtat  aatcttgac  gtttctgcc  660
gtcctaatg  cagagctct  tgac  684



<210> 10181
<211> 201
<212> PRT
<213> Homo sapiens
<308> Q15363
<400> 10181

Met Val Thr Leu Ala Glu Leu Leu Val Leu Leu Ala Ala Leu Leu Ala 
  1               5                  10                  15
Thr Val Ser Gly Tyr Phe Val Ser Ile Asp Ala His Ala Glu Glu Cys 
             20                  25                  30
Phe Phe Glu Arg Val Thr Ser Gly Thr Lys Met Gly Leu Ile Phe Glu 
         35                  40                  45
Val Ala Glu Gly Gly Phe Leu Asp Ile Asp Val Glu Ile Thr Gly Pro 
     50                  55                  60
Asp Asn Lys Gly Ile Tyr Lys Gly Asp Arg Glu Ser Ser Gly Lys Tyr 
 65                  70                  75                  80
Thr Phe Ala Ala His Met Asp Gly Thr Tyr Lys Phe Cys Phe Ser Asn 
                 85                  90                  95
Arg Met Ser Thr Met Thr Pro Lys Ile Val Met Phe Thr Ile Asp Ile 
             100                105                110
Gly Glu Ala Pro Lys Gly Gln Asp Met Glu Thr Glu Ala His Gln Asn 
         115                120                125
Lys Leu Glu Glu Met Ile Asn Glu Leu Ala Val Ala Met Thr Ala Val 
     130                135                140
Lys His Glu Gln Glu Tyr Met Glu Val Arg Glu Arg Ile His Arg Ala 
 145                150                155                160
Ile Asn Asp Asn Thr Asn Ser Arg Val Val Leu Trp Ser Phe Phe Glu 
                 165                170                175
Ala Leu Val Leu Val Ala Met Thr Leu Gly Gln Ile Tyr Tyr Leu Lys 
             180                185                190
Arg Phe Phe Glu Val Arg Arg Val Val 
         195                200



<210> 10182
<211> 6524
<212> DNA
<213> Rattus norvegicus
<308> X92184
<400> 10182

tagcttgct  ctgctaatg  taccccagg  ctttagaca  agaacagat  gcagatgga  60
tttcttatt  ccatgcgca  acgctgagc  cacctcatg  tcccggacc  catggtttt  120
agtagacaa  ctgggctaa  aagagatct  cgaccttat  gagcagcaa  gagtgtaaa  180
tcttcccca  gaagaatga  aagatggag  tcccctttg  gtccgtggg  actaccaat  240
tcagacggt  cactccaga  tcactggca  agatcgaga  gcagattgc  gctcaccgc  300
cagccaaga  ggccagaac  aagcacaga  gacaggagg  caagggcga  aagcccagg  360
ctcagctgg  cttgaaaga  tgtaaccag  tgcccaagt  ctatggtga  ctcccagca  420
aactggtcg  ggagcccct  gaggaccta  accctttct  cagcacaca  cggacattc  480
tggtgttga  taaaagcag  accatttcc  gattcagtg  cacttgggc  ctgtggctc  540
tcagtccct  caacctgat  agaagaaca  ccatcaaag  gtctgtcca  tcctggttc  600
ccatattca  caccatcac  attttggtc  actgcgtgt  catgacccg  actgatctt  660
cagagaaag  cgagtacgt  ttcactgtc  tttacacct  cgaggctct  attaagata  720
tggcaagag  gttttgtct  aatgagttc  cttatcttc  agatccgtg  aactggctg  780
acttcagtg  cattacctt  gcgtatgtg  gtgcagcga  agacctccg  ggaatctca  840
gcctgcgga  attccgagt  ctcagagcc  tgaaaactg  ttctgtgat  ccaggactg  900
aggtcatcg  gggagccct  atccactca  tgaggaagc  ggccgacgt  actatcctc  960
cagtcttct  cctgagcgt  ttcgccttg  tgggcctgc  gctctttaa  gggaacctt  1020
agaacaaat  catcaggaa  ggaacagat  cccacaagg  tgacaacct  tcatctgaa  1080
tggcagaat  catcttcat  aagcctggt  ctacggatc  cttactgtg  ggcaatggg  1140
ctgatgctg  tcactgccc  ggaggctat  tctgcctga  aactcctga  aacccggat  1200
ttaactaca  cagctttga  tcctttgcg  gggcattcc  ctcactgtt  cgcctcatg  1260
cgcaggact  ctgggagcg  ctgtaccag  agacactcc  ggcttctgg  aaaatgtac  1320
tggtctttt  cgtgctggt  attttcctt  gatcgttct  cctggtcaa  ttgatcttg  1380
ccgtggtca  catggcgta  gaagagcag  gccaggcaa  aattgcaga  atcgaagcc  1440
aggaaaaaa  gttccagga  gcccttgag  tgctgcaga  ggaacagga  gtgctggaa  1500
ccctgggga  tgacacgac  tcgctccag  cccacagtg  atcaccctt  gcctccaaa  1560
acgccaatg  gagaagacc  agggtgaaa  caagggtgt  agagggctc  acggatgac  1620
acaggtcac  ccaatctga  ccttacaac  agcgcagga  gtctttcct  ggcctgtct  1680
caggaagac  cagggctag  cacggcagt  tgttccact  ccgagcgcc  agccaagac  1740
tctcatttc  tgacgggat  acccctgat  atggggtct  tcacggaga  caggaaagc  1800
gtcgaggtt  catattgct  ggcaggggt  ctgggcaga  aggtccact  cccaggagc  1860
cactgcctc  gtcccccaa  cctggccgt  gacatggag  agagggaca  ctcggagtg  1920
ccactggtg  gcttaccgc  ggagcgcct  aaggcccgg  actgcacac  acagggcag  1980
agagcttcc  gtctgcggg  tacttgaac  aacctttcc  agcacagag  gccatgagc  2040
ttgtcagta  catgacttc  gtcattgag  agcttgaag  gtctaagct  aagtgccca  2100
cctgcttga  cagcttcgc  cagaagtat  tgatctggg  gtgctgccc  aagtggagg  2160
agttcaaga  ggcgctgtt  gagctggtg  ctgacccct  cgcagagct  accatcacc  2220
tctgcatcg  ggtgaacac  gtcttcatg  ccatggagc  ctaccccat  accgatgcc  2280
tcgatgcca  gcttcaagc  ggcaacatt  tcttcaccg  gtttttcac  atggagatg  2340
ccttcaaga  cattgcctt  gacccctac  attacttcc  gaagaagtg  aatatcttc  2400
actgtgtca  cgtcaccgt  agccttctg  agctgagtg  atccaagaa  ggcagcctg  2460
ctgtgctcc  taccttacg  ttgctgcgg  tcttcaagc  ggccaagtc  tggcccacc  2520
tgaacaccc  catcaagat  atcgggaac  cagtggggg  cctgggcaa  ctgaccttt  2580
tcctggcca  catcgtctt  atcttcgcc  tggtcggaa  gcagcttct  tcagaggac  2640
acgggtgcc  caaggacgg  gtctccgtg  ggaacggcg  gaagctccg  tggcacatg  2700
gtgacttct  ccattcctt  ctggtcgtc  tccgaatcc  ctgcgggga  tggatcgag  2760
acatgtggg  ctgcatgga  gtcagccag  aatccatct  cctcatcct  ttcttgact  2820
tgatggtgc  gggcaacct  gtggtgctc  accttttca  cgctttact  ctgaactcc  2880
tcagcgcgg  caacctcac  gctccagag  atgacgggg  ggtgaacaa  ttgcagtta  2940
cactggcca  gatccaggt  cttggccat  gggccagca  ggccatcgc  agttacatc  3000
gcagccact  ccgattcca  tggcccaag  tggagaccc  gctgggcat  aagccccca  3060
tcaccagct  agaggccaa  aaccacatt  ccactgatg  tgtcagtgc  gcagtgggg  3120
acctgacaa  gccagctct  agtagcccc  aggagaacc  cggggactt  atcactgat  3180
ccaacgtgt  ggtctctgt  cccattgct  agggggaat  tgacctcga  gagctcgag  3240
aagatatgg  gcaggcttc  cagagctcc  ggcaggaag  ggaccccaa  ggacagcag  3300
agcagttgc  acaagtcca  aagtgtgaa  accaccagg  agccagaag  ccagcctcc  3360
tgatgtcct  tgaggacct  gctccatac  tgggtgaga  ctggaagag  aaggatagc  3420
ctcaggtcc  tgccgaggg  gtggatgac  cgagctcct  tgagggcag  acggtggac  3480
gcccggacc  agaggaaat  ctgaggaag  tccccgagc  ggcagatga  ctggacgag  3540
ccgatgact  tttcacaga  ggctgcact  gccgctgtc  ctgctgcaa  gtgaatact  3600
gcaagtctc  ttgggccac  ggctggcag  tgcgcaaga  ctgctaccg  atcgtggag  3660
acagctggt  tgagagttt  atcatcttc  tgatcctgc  cagcagtgg  gcgctggcc  3720
ttgaggata  ctacctgga  gagaaaccc  gagtgaagt  cgtgctgga  tacactgac  3780
gagtgttca  cttcatctt  gtctttgag  tgctgctca  gtgggtagc  tatggcttc  3840
aaaagtatt  caccaatgc  tggtgctgg  tggacttcc  cattgtgaa  atctccctg  3900
caagcctca  agcgaagat  cttgagtat  ccgacgtgg  gtccatcaa  gcccttcgg  3960
ctctccgtg  cctccgacc  ctgcgggct  tgtctcgat  cgaaggcat  agggtagtg  4020
tggatgccc  cgtgggcgc  atcccctcc  tcatgaacg  cctcctcgt  tgcctcatc  4080
tctggctca  cttcagcat  atgggcgtg  acctcttcg  cgggaaatt  tcgaagtgc  4140
tcgacacca  aaataaccc  ttttccaac  tgaattcga  gatggtgaa  aacaagtcc  4200
agtgtcaca  tcaaaacag  accggccac  tcttctggg  caacgtcaa  gtcaacttc  4260
acaacgtcg  tatgggcta  ctcgcactt  ttcaggtgg  aaccttcaa  ggctggatg  4320
acataatgt  tgcagctgt  gattccgga  agatcaaca  tcagcctaa  tgggagaac  4380
acttgtaca  gtacctgta  ttcgtcgtt  tcatcattt  cggtggctt  ttcacgctg  4440
atctctttg  tggggtcat  atcgacaac  tcaaccaac  gaaaaaaaa  ctaggaggc  4500
aggacatct  catgacaga  gagcagaag  agtactaca  tgccatgaa  aagctgggc  4560
ccaagaaac  ccagaagcc  atcccacgg  ccctgaata  gtaccaagg  ttcgtgttt  4620
acatcgtga  caggcaagc  tttgacatc  tcatcatgg  tctcatctg  ctcaacatg  4680
tcaccatga  ggtggagac  gacgagcag  gcgaggaga  gacgaaggt  ctgggcaga  4740
tcaaccagt  ctttgtggc  gtcttcacg  gcgagtgtg  gatgaagat  ttcgccctg  4800
gacagtact  cttcaccaa  ggctggaac  tgttcgact  catagtggt  atcctgtcc  4860
ttgggagtc  gctgttttc  gcaatcctt  agtcactgg  aaactactt  tccccgacg  4920
tcttccggg  catccgtct  gccaggatc  gccgcatcc  caggctgat  cgagcagcc  4980
aggggattc  cacgctgct  ttcgccctc  tgatgtccc  gcccgccct  ttcaacatc  5040
gcctcctcc  cttcctcgt  atgttcatc  actccatct  cggcatggc  agcttcgct  5100
acgtcgtgg  cgaggccgg  atcgacgac  tgttcaact  caagacctt  ggcaacagc  5160
tgctgtgcc  gttccagat  accacctcg  ccggctggg  cggcctcct  agccccatc  5220
tcaacacgg  gcctcccta  tgcgacccc  acctgccca  cagcaacgg  tcccggggg  5280
actgcggga  cccggcggt  ggcatcatc  tcttcacca  ctacatcat  atctccttc  5340
tcatcgtgg  caacatgta  atcgcagtg  ttctggaga  cttcaacgt  gccaccgag  5400
agagcacgg  gcccctgag  gaggacgac  tcgacatgt  ctatgagac  tgggagaag  5460
tcgacccgg  ggccaccca  ttcattgcc  tttctgccc  ctcagactt  gcggacacg  5520
tctccggcc  tcttagaat  cccaaaccc  accagaata  attaatcca  atggacctg  5580
cgttggtcc  cggggataa  atccactgt  tggacatcc  ttttgcctt  acaaagaac  5640
tcttgggag  atccgggga  ttggactcc  tgaagacca  tatggaaga  aagtttatg  5700
cgaccaatc  ctccaaagc  tcctatgaa  caatagcca  caccctccg  tggaagcag  5760
aagacctct  agccacagt  attcaaaag  cctaccgga  ctacatgct  caccgctcc  5820
tgacactct  caacaccct  catgtgccc  gggctgagg  ggatggcgt  tcacttccc  5880
gggaaggct  cattacatt  atggcaaac  gtggactcc  ggacaaatc  gaaactgcc  5940
ctgctacgt  tttcccgcc  tcctatgac  gtgtcacca  gggcctgag  gaccgggcc  6000
acattaacc  atctagctc  atgcaaaat  aagatgagg  cgctgctaa  gaaggaaac  6060
gccctggac  tcagtgaag  cactcaggc  tgcacaggg  aggttccaa  gtctttctc  6120
gctgtacta  ctccttccc  ctggaggtg  caccaacct  cagcctcca  caatgcatg  6180
cactggtca  ggtgtcaga  ctgaatggg  acatccttg  gaaagcccc  accccaata  6240
gaatcaaaa  ccaaggata  tcctccatt  tgacgtccc  tccgagttc  cagaagatg  6300
cattgctcc  ttctgtttg  gaccagaga  gtgattcac  aacttctcg  agccagaga  6360
acatagcaa  gacttttct  ctggtgtcg  gcagtctta  agaagtcac  taggggttg  6420
tactgagaa  tagggtttg  atgactgca  gctcacagc  gccggacaa  acctgtgag  6480
cggccatta  aattaatat  tttaaagtt  aaaaaaaaa  aaaa  6524



<210> 10183
<211> 1957
<212> PRT
<213> Rattus norvegicus
<308> CAA63095
<400> 10183

Met Glu Leu Pro Phe Ala Ser Val Gly Thr Thr Asn Phe Arg Arg Phe 
  1               5                  10                  15
Thr Pro Glu Ser Leu Ala Glu Ile Glu Lys Gln Ile Ala Ala His Arg 
             20                  25                  30
Ala Ala Lys Lys Ala Arg Thr Lys His Arg Gly Gln Glu Asp Lys Gly 
         35                  40                  45
Glu Lys Pro Arg Pro Gln Leu Asp Leu Lys Asp Cys Asn Gln Leu Pro 
     50                  55                  60
Lys Phe Tyr Gly Glu Leu Pro Ala Glu Leu Val Gly Glu Pro Leu Glu 
 65                  70                  75                  80
Asp Leu Asp Pro Phe Tyr Ser Thr His Arg Thr Phe Met Val Leu Asn 
                 85                  90                  95
Lys Ser Arg Thr Ile Ser Arg Phe Ser Ala Thr Trp Ala Leu Trp Leu 
             100                105                110
Phe Ser Pro Phe Asn Leu Ile Arg Arg Thr Ala Ile Lys Val Ser Val 
         115                120                125
His Ser Trp Phe Ser Ile Phe Ile Thr Ile Thr Ile Leu Val Asn Cys 
     130                135                140
Val Cys Met Thr Arg Thr Asp Leu Pro Glu Lys Val Glu Tyr Val Phe 
 145                150                155                160
Thr Val Ile Tyr Thr Phe Glu Ala Leu Ile Lys Ile Leu Ala Arg Gly 
                 165                170                175
Phe Cys Leu Asn Glu Phe Thr Tyr Leu Arg Asp Pro Trp Asn Trp Leu 
             180                185                190
Asp Phe Ser Val Ile Thr Leu Ala Tyr Val Gly Ala Ala Ile Asp Leu 
         195                200                205
Arg Gly Ile Ser Gly Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys 
     210                215                220
Thr Val Ser Val Ile Pro Gly Leu Lys Val Ile Val Gly Ala Leu Ile 
 225                230                235                240
His Ser Val Arg Lys Leu Ala Asp Val Thr Ile Leu Thr Val Phe Cys 
                 245                250                255
Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe Lys Gly Asn Leu 
             260                265                270
Lys Asn Lys Cys Ile Arg Asn Gly Thr Asp Pro His Lys Ala Asp Asn 
         275                280                285
Leu Ser Ser Glu Met Ala Glu Tyr Ile Phe Ile Lys Pro Gly Thr Thr 
     290                295                300
Asp Pro Leu Leu Cys Gly Asn Gly Ser Asp Ala Gly His Cys Pro Gly 
 305                310                315                320
Gly Tyr Val Cys Leu Lys Thr Pro Asp Asn Pro Asp Phe Asn Tyr Thr 
                 325                330                335
Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ser Leu Phe Arg Leu Met 
             340                345                350
Thr Gln Asp Ser Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ala Ser 
         355                360                365
Gly Lys Met Tyr Met Val Phe Phe Val Leu Val Ile Phe Leu Gly Ser 
     370                375                380
Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Thr Met Ala Tyr Glu 
 385                390                395                400
Glu Gln Ser Gln Ala Thr Ile Ala Glu Ile Glu Ala Lys Glu Lys Lys 
                 405                410                415
Phe Gln Glu Ala Leu Glu Val Leu Gln Lys Glu Gln Glu Val Leu Glu 
             420                425                430
Ala Leu Gly Ile Asp Thr Thr Ser Leu Gln Ser His Ser Gly Ser Pro 
         435                440                445
Leu Ala Ser Lys Asn Ala Asn Glu Arg Arg Pro Arg Val Lys Ser Arg 
     450                455                460
Val Ser Glu Gly Ser Thr Asp Asp Asn Arg Ser Pro Gln Ser Asp Pro 
 465                470                475                480
Tyr Asn Gln Arg Arg Met Ser Phe Leu Gly Leu Ser Ser Gly Arg Arg 
                 485                490                495
Arg Ala Ser His Gly Ser Val Phe His Phe Arg Ala Pro Ser Gln Asp 
             500                505                510
Ile Ser Phe Pro Asp Gly Ile Thr Pro Asp Asp Gly Val Phe His Gly 
         515                520                525
Asp Gln Glu Ser Arg Arg Gly Ser Ile Leu Leu Gly Arg Gly Ala Gly 
     530                535                540
Gln Thr Gly Pro Leu Pro Arg Ser Pro Leu Pro Gln Ser Pro Asn Pro 
 545                550                555                560
Gly Arg Arg His Gly Glu Glu Gly Gln Leu Gly Val Pro Thr Gly Glu 
                 565                570                575
Leu Thr Ala Gly Ala Pro Glu Gly Pro Ala Leu His Thr Thr Gly Gln 
             580                585                590
Lys Ser Phe Leu Ser Ala Gly Tyr Leu Asn Glu Pro Phe Arg Ala Gln 
         595                600                605
Arg Ala Met Ser Val Val Ser Ile Met Thr Ser Val Ile Glu Glu Leu 
     610                615                620
Glu Glu Ser Lys Leu Lys Cys Pro Pro Cys Leu Ile Ser Phe Ala Gln 
 625                630                635                640
Lys Tyr Leu Ile Trp Glu Cys Cys Pro Lys Trp Arg Lys Phe Lys Met 
                 645                650                655
Ala Leu Phe Glu Leu Val Thr Asp Pro Phe Ala Glu Leu Thr Ile Thr 
             660                665                670
Leu Cys Ile Val Val Asn Thr Val Phe Met Ala Met Glu His Tyr Pro 
         675                680                685
Met Thr Asp Ala Phe Asp Ala Met Leu Gln Ala Gly Asn Ile Val Phe 
     690                695                700
Thr Val Phe Phe Thr Met Glu Met Ala Phe Lys Ile Ile Ala Phe Asp 
 705                710                715                720
Pro Tyr Tyr Tyr Phe Gln Lys Lys Trp Asn Ile Phe Asp Cys Val Ile 
                 725                730                735
Val Thr Val Ser Leu Leu Glu Leu Ser Ala Ser Lys Lys Gly Ser Leu 
             740                745                750
Ser Val Leu Arg Thr Leu Arg Leu Leu Arg Val Phe Lys Leu Ala Lys 
         755                760                765
Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile Gly Asn Ser Val 
     770                775                780
Gly Ala Leu Gly Asn Leu Thr Phe Ile Leu Ala Ile Ile Val Phe Ile 
 785                790                795                800
Phe Ala Leu Val Gly Lys Gln Leu Leu Ser Glu Asp Tyr Gly Cys Arg 
                 805                810                815
Lys Asp Gly Val Ser Val Trp Asn Gly Glu Lys Leu Arg Trp His Met 
             820                825                830
Cys Asp Phe Phe His Ser Phe Leu Val Val Phe Arg Ile Leu Cys Gly 
         835                840                845
Glu Trp Ile Glu Asn Met Trp Val Cys Met Glu Val Ser Gln Lys Ser 
     850                855                860
Ile Cys Leu Ile Leu Phe Leu Thr Val Met Val Leu Gly Asn Leu Val 
 865                870                875                880
Val Leu Asn Leu Phe Ile Ala Leu Leu Leu Asn Ser Phe Ser Ala Asp 
                 885                890                895
Asn Leu Thr Ala Pro Glu Asp Asp Gly Glu Val Asn Asn Leu Gln Leu 
             900                905                910
Ala Leu Ala Arg Ile Gln Val Leu Gly His Arg Ala Ser Arg Ala Ile 
         915                920                925
Ala Ser Tyr Ile Ser Ser His Cys Arg Phe His Trp Pro Lys Val Glu 
     930                935                940
Thr Gln Leu Gly Met Lys Pro Pro Leu Thr Ser Ser Glu Ala Lys Asn 
 945                950                955                960
His Ile Ala Thr Asp Ala Val Ser Ala Ala Val Gly Asn Leu Thr Lys 
                 965                970                975
Pro Ala Leu Ser Ser Pro Lys Glu Asn His Gly Asp Phe Ile Thr Asp 
             980                985                990
Pro Asn Val Trp Val Ser Val Pro Ile Ala Glu Gly Glu Ser Asp Leu 
         995                1000                1005
Asp Glu Leu Glu Glu Asp Met Glu Gln Ala Ser Gln Ser Ser Trp Gln 
     1010                1015                1020
Glu Glu Asp Pro Lys Gly Gln Gln Glu Gln Leu Pro Gln Val Gln Lys 
 1025                1030                1035                1040
Cys Glu Asn His Gln Ala Ala Arg Ser Pro Ala Ser Met Met Ser Ser 
                 1045                1050                1055
Glu Asp Leu Ala Pro Tyr Leu Gly Glu Ser Trp Lys Arg Lys Asp Ser 
             1060                1065                1070
Pro Gln Val Pro Ala Glu Gly Val Asp Asp Thr Ser Ser Ser Glu Gly 
         1075                1080                1085
Ser Thr Val Asp Cys Pro Asp Pro Glu Glu Ile Leu Arg Lys Ile Pro 
     1090                1095                1100
Glu Leu Ala Asp Asp Leu Asp Glu Pro Asp Asp Cys Phe Thr Glu Gly 
 1105                1110                1115                1120
Cys Thr Arg Arg Cys Pro Cys Cys Asn Val Asn Thr Ser Lys Ser Pro 
                 1125                1130                1135
Trp Ala Thr Gly Trp Gln Val Arg Lys Thr Cys Tyr Arg Ile Val Glu 
             1140                1145                1150
His Ser Trp Phe Glu Ser Phe Ile Ile Phe Met Ile Leu Leu Ser Ser 
         1155                1160                1165
Gly Ala Leu Ala Phe Glu Asp Asn Tyr Leu Glu Glu Lys Pro Arg Val 
     1170                1175                1180
Lys Ser Val Leu Glu Tyr Thr Asp Arg Val Phe Thr Phe Ile Phe Val 
 1185                1190                1195                1200
Phe Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Phe Lys Lys Tyr Phe 
                 1205                1210                1215
Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile Val Asn Ile Ser Leu 
             1220                1225                1230
Thr Ser Leu Ile Ala Lys Ile Leu Glu Tyr Ser Asp Val Ala Ser Ile 
         1235                1240                1245
Lys Ala Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg Ala Leu Ser 
     1250                1255                1260
Arg Phe Glu Gly Met Arg Val Val Val Asp Ala Leu Val Gly Ala Ile 
 1265                1270                1275                1280
Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile Phe Trp Leu Ile 
                 1285                1290                1295
Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys Phe Ser Lys Cys 
             1300                1305                1310
Val Asp Thr Arg Asn Asn Pro Phe Ser Asn Val Asn Ser Thr Met Val 
         1315                1320                1325
Asn Asn Lys Ser Glu Cys His Asn Gln Asn Ser Thr Gly His Phe Phe 
     1330                1335                1340
Trp Val Asn Val Lys Val Asn Phe Asp Asn Val Ala Met Gly Tyr Leu 
 1345                1350                1355                1360
Ala Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp Ile Met Tyr 
                 1365                1370                1375
Ala Ala Val Asp Ser Gly Glu Ile Asn Ser Gln Pro Asn Trp Glu Asn 
             1380                1385                1390
Asn Leu Tyr Met Tyr Leu Tyr Phe Val Val Phe Ile Ile Phe Gly Gly 
         1395                1400                1405
Phe Phe Thr Leu Asn Leu Phe Val Gly Val Ile Ile Asp Asn Phe Asn 
     1410                1415                1420
Gln Gln Lys Lys Lys Leu Gly Gly Gln Asp Ile Phe Met Thr Glu Glu 
 1425                1430                1435                1440
Gln Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser Lys Lys Pro 
                 1445                1450                1455
Gln Lys Pro Ile Pro Arg Pro Leu Asn Lys Tyr Gln Gly Phe Val Phe 
             1460                1465                1470
Asp Ile Val Thr Arg Gln Ala Phe Asp Ile Ile Ile Met Val Leu Ile 
         1475                1480                1485
Cys Leu Asn Met Ile Thr Met Met Val Glu Thr Asp Glu Gln Gly Glu 
     1490                1495                1500
Glu Lys Thr Lys Val Leu Gly Arg Ile Asn Gln Phe Phe Val Ala Val 
 1505                1510                1515                1520
Phe Thr Gly Glu Cys Val Met Lys Met Phe Ala Leu Arg Gln Tyr Tyr 
                 1525                1530                1535
Phe Thr Asn Gly Trp Asn Val Phe Asp Phe Ile Val Val Ile Leu Ser 
             1540                1545                1550
Ile Gly Ser Leu Leu Phe Ser Ala Ile Leu Lys Ser Leu Glu Asn Tyr 
         1555                1560                1565
Phe Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly Arg 
     1570                1575                1580
Ile Leu Arg Leu Ile Arg Ala Ala Lys Gly Ile Arg Thr Leu Leu Phe 
 1585                1590                1595                1600
Ala Leu Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu Leu 
                 1605                1610                1615
Phe Leu Val Met Phe Ile Tyr Ser Ile Phe Gly Met Ala Ser Phe Ala 
             1620                1625                1630
Asn Val Val Asp Glu Ala Gly Ile Asp Asp Met Phe Asn Phe Lys Thr 
         1635                1640                1645
Phe Gly Asn Ser Met Leu Cys Leu Phe Gln Ile Thr Thr Ser Ala Gly 
     1650                1655                1660
Trp Asp Gly Leu Leu Ser Pro Ile Leu Asn Thr Gly Pro Pro Tyr Cys 
 1665                1670                1675                1680
Asp Pro Asn Leu Pro Asn Ser Asn Gly Ser Arg Gly Asn Cys Gly Ser 
                 1685                1690                1695
Pro Ala Val Gly Ile Ile Phe Phe Thr Thr Tyr Ile Ile Ile Ser Phe 
             1700                1705                1710
Leu Ile Val Val Asn Met Tyr Ile Ala Val Ile Leu Glu Asn Phe Asn 
         1715                1720                1725
Val Ala Thr Glu Glu Ser Thr Glu Pro Leu Ser Glu Asp Asp Phe Asp 
     1730                1735                1740
Met Phe Tyr Glu Thr Trp Glu Lys Phe Asp Pro Glu Ala Thr Gln Phe 
 1745                1750                1755                1760
Ile Ala Phe Ser Ala Leu Ser Asp Phe Ala Asp Thr Leu Ser Gly Pro 
                 1765                1770                1775
Leu Arg Ile Pro Lys Pro Asn Gln Asn Ile Leu Ile Gln Met Asp Leu 
             1780                1785                1790
Pro Leu Val Pro Gly Asp Lys Ile His Cys Leu Asp Ile Leu Phe Ala 
         1795                1800                1805
Phe Thr Lys Asn Val Leu Gly Glu Ser Gly Glu Leu Asp Ser Leu Lys 
     1810                1815                1820
Thr Asn Met Glu Glu Lys Phe Met Ala Thr Asn Leu Ser Lys Ala Ser 
 1825                1830                1835                1840
Tyr Glu Pro Ile Ala Thr Thr Leu Arg Trp Lys Gln Glu Asp Leu Ser 
                 1845                1850                1855
Ala Thr Val Ile Gln Lys Ala Tyr Arg Ser Tyr Met Leu His Arg Ser 
             1860                1865                1870
Leu Thr Leu Ser Asn Thr Leu His Val Pro Arg Ala Glu Glu Asp Gly 
         1875                1880                1885
Val Ser Leu Pro Gly Glu Gly Tyr Ile Thr Phe Met Ala Asn Ser Gly 
     1890                1895                1900
Leu Pro Asp Lys Ser Glu Thr Ala Ser Ala Thr Ser Phe Pro Pro Ser 
 1905                1910                1915                1920
Tyr Asp Ser Val Thr Arg Gly Leu Ser Asp Arg Ala Asn Ile Asn Pro 
                 1925                1930                1935
Ser Ser Ser Met Gln Asn Glu Asp Glu Val Ala Ala Lys Glu Gly Asn 
             1940                1945                1950
Ser Pro Gly Pro Gln 
         1955



<210> 10184
<211> 8491
<212> DNA
<213> Homo sapiens
<308> M77235
<400> 10184

gccgctgag  ctgcgccca  tgccccgag  cccgcgccg  gccgagtcc  cgccaagca  60
cagccgccc  ccccggggc  cggccgggg  accagcagc  tccccacag  caacgtgag  120
agagcctgt  cccagaagc  ggatgagaa  atggcaaac  tcctattac  tcggggcac  180
agcagcttc  gcaggttca  acgggagtc  ctggcagcc  tcgagaagc  catggcgga  240
aagcaagcc  gcggctcaa  caccttgca  gagagccga  aggggctgc  cgaggagga  300
gctccccgg  cccagctgg  cctgcaggc  tccaaaaag  tgccagatc  ctatggcaa  360
ccaccccaa  agctcatcg  agagcccct  gaggacctg  accccttct  tagcaccca  420
aagactttc  tcgtactga  taaaggcaa  accatcttc  ggttcagtg  caccaacgc  480
ttgtatgtc  tcagtccct  ccacccagt  cggagagcg  ctgtgaaga  tctggttca  540
tcgctcttc  acatgctca  catgtgcac  atcctcacc  actgcgtgt  catggccca  600
cacgaccct  caccctgga  caagtatgt  gagtacacc  tcaccgcca  ttacacctt  660
gagtctctg  tcaagattc  ggctcgagc  ttctgcctg  acgcgttca  tttccttcg  720
gacccatgg  actggctgg  ctttagtgt  attatcatg  catacacaa  tgaatttgt  780
gacctgggc  atgtctcag  cttacgcac  ttccgagtc  tccgggccc  gaaaactat  840
tcagtcatt  cagggctga  gaccatcgt  ggggccctg  tccagtctg  gaagaagct  900
gctgatgtg  tggtcctca  agtcttctg  ctcagcgtc  ttgccctca  cggcctgca  960
ctcttcatg  gcaacctaa  gcacaagtg  gtgcgcaac  tcacagcgc  caacggcac  1020
aacggctcc  tggaggccg  cggcttggt  tgggaatcc  tggaccttt  cctcagtga  1080
ccagaaaat  acctgctca  gaacggcac  tctgatgtg  tactgtgtg  gaacagctc  1140
gacgctggg  catgtccgg  gggctaccg  tgcctaaag  caggcgaga  ccccgacca  1200
ggctacacc  gcttcgatt  ctttgcctg  gcctttctt  cactcttcc  cctgatgac  1260
caggactgc  gggagcgcc  ctatcagca  accctcagg  ccgcaggga  gatctacat  1320
atcttcttc  tgcttgtca  cttcctggg  tccttctac  tggtgaacc  gatcctggc  1380
gtggtcgca  tggcctatg  ggagcaaaa  caagccacc  tcgctgaga  cgaggagaa  1440
gaaaagcgc  tccaggagg  catggaaat  ctcaagaaa  aacacgagg  cctcaccat  1500
aggggtgtg  ataccgtgt  ccgtagctc  ttggagatg  cccctttgg  cccagtaaa  1560
agccatgag  gaagaagca  gaggagaaa  cggatgtct  caggaactg  ggagtgtgg  1620
gaggacagg  tccccaagt  tgactcaga  gatggtccc  gagcaatga  tcatctcag  1680
ctcacccgt  gcctcagca  gacttctat  aagccacgt  ccagccgcg  gagcatttt  1740
acctttcgc  ggcgagacc  gggttctga  gcagatttt  cagatgatg  aaacagcac  1800
gcgcgggag  gcgagagcc  ccacacatc  ctgctggtg  cctggcccc  gcgccggac  1860
agtgcccag  gacagccca  tcccggaac  tcggctcct  gccacgccc  ccatggcaa  1920
aagaacagc  ctgtggact  caatggggt  gtctcatta  tgggggcag  cgacccaga  1980
gccacatcc  caggaagcc  cctcctccg  cctgtgatg  tagagcacc  gccagacac  2040
accacgcca  cggaggagc  aggcggccc  cagatgctg  cctcccagg  tccgtgtgt  2100
gatggcttc  aggagccag  agcacggca  cgggccctc  gcgcagtca  cgtcctcac  2160
agcgcactg  aagagttag  ggagtctcg  cacaagtgt  caccatgct  gaaccgtct  2220
gcccagcgc  acctgatct  ggagtgctg  ccgctgtgg  tgtccatca  gcagggagt  2280
aagttggtg  tcatggacc  gtttactga  ctcaccatc  ctatgtgca  cgtactcaa  2340
acactcttc  tggcgctgg  gcactacaa  atgacaagt  aattcgagg  gatgctgca  2400
gtcggaaac  tggtcttca  agggatttt  acagcagag  tgaccttca  gatcattgc  2460
ctcgacccc  actactact  ccaacaggg  tggaacatc  tcgacagca  catcgtcat  2520
cttagcctc  tggagctgg  cctgtcccg  atgagcaac  tgtcggtgc  gcgctcctt  2580
cgcctgctg  gggtcttca  gctggccaa  tcatggccc  ccctgaaca  actcatcaa  2640
atcatcggg  actcagtgg  ggcactggg  aacctgaca  tggtgctag  catcatcgt  2700
ttcatcttt  ctgtggtgg  catgcagct  tttggcaag  actactcgg  gctgaggga  2760
agcgactca  gcctgctgc  tcgctggca  atgatggac  tctttcatg  cttcctaat  2820
atcttccgc  tcctctgtg  agagtggat  gagaccatg  gggactgca  ggaggtgtc  2880
gggcagtca  tatgcctgc  ggtcttctt  cttgttatg  tcattggca  ccttgtggt  2940
ctgaatctc  tcctggcct  gctgctcag  tccttcagt  cagacaacc  cacagcccc  3000
gatgaggac  gagagatga  caacctcca  ctggccctg  cccgcatcc  gaggggcct  3060
cgctttgtc  agcggacca  ctgggattt  tgctgtggt  tcctgcggc  ccggcctca  3120
aagcccgca  cccttgccg  ccagggcca  ctgcccagc  gcattgcca  cccctactc  3180
ccgccaccc  cagagacgg  gaaggtgcc  cccacccgc  aggaaacac  gtttgagga  3240
ggcgagcaa  caggccagg  cacccccgg  gatccagag  ccgtgtgtg  gcccatcgc  3300
gtggccgag  cagacacag  tgaccaaga  gaggatgag  agaacagcc  gggcacgga  3360
gaggagtcc  gcaagcagc  ggaatccca  cctgtgtcc  gctggccca  aggccctcc  3420
gattccagg  cctggagcc  ggtgtcagc  actgcctcc  ctgaggccg  ggccagtgc  3480
tctcaggcc  actggcggc  gcagtggaa  gcggaaccc  aggccccag  gtgcggtga  3540
accccagag  acagttgct  cgagggcag  acagcagac  tgaccaaca  cgctgagct  3600
ctggagcag  tccctgacc  cggccagga  gtcaaggac  cagaggact  cttcactga  3660
ggctgtgtc  ggcgctgtc  ctgctgtgc  gtggacacc  cacaggccc  agggaaggt  3720
tggtggcgg  tgcgcaaga  ctgctacca  atcgtggag  acagctggt  cgagacatt  3780
atcatcttc  tgatcctac  cagcagtgg  gcgctggcc  tcgaggaca  ctacctaga  3840
gagcggaag  ccatcaagg  tctgcttga  tatgccgac  agatgttca  atatgtctt  3900
gtgctggag  tgctgctca  gtgggtggc  tacggcttc  agaagtact  caccaatgc  3960
tggtgctgg  tcgacttcc  catcgtaga  gtctctctg  tcagcctgg  ggccaacac  4020
ctgggcttt  ccgagatgg  ccccatcaa  tcactgcgg  cgctgcgtg  actccgtcc  4080
ctgagagct  tgtcacgat  tgagggcat  agggtggtg  tcaatgccc  ggtgggcgc  4140
atcccgtcc  tcatgaacg  cctcctcgt  tgcctcatc  tctggctca  cttcagcat  4200
atgggcgtg  acctctttg  ggggaagtt  gggaggtgc  tcaaccaga  agagggaga  4260
ttgcctttg  actacacca  cgtgaacaa  aagagccag  gtgagtcct  gaacttgac  4320
ggagaattg  actggacca  ggtgaaagt  aactttgac  acgtggggg  cgggtacct  4380
gcccttctg  aggtggcaa  atttaaagg  tggatggac  ttatgtatg  agctgtgga  4440
tccaggggg  atgaagagc  gcctcagtg  gaatacaac  tctacatgt  catctattt  4500
gtcattttc  tcatctttg  gtctttctt  accctgaac  tctttattg  tgtcatcat  4560
gacaacttc  accaacaga  gaaaaagtt  gggggccag  acatcttca  gacagagga  4620
cagaagaag  actacaatg  catgaagaa  ctgggctcc  agaagcccc  gaagcccat  4680
ccacggccc  tgaacaagt  ccagggctt  atattcgac  ttgtgacca  gcaggcctt  4740
gacgtcacc  tcatgtttc  gatctgctt  aatatggtg  ccatgatgg  ggagacaga  4800
gaccaaagt  ctgagaaaa  caacatctt  gccaagatc  acctgctct  tgtggccat  4860
ttcacaggc  agtgtattg  caagctggc  gccctgcgc  actactact  caccaacag  4920
tggaatatc  tcgacttcg  ggttgtcat  ctctccatc  tgggcactg  gctctcgga  4980
atcatccag  agtacttct  ctccccgac  ctcttccga  tcatccgcc  ggcccgaat  5040
ggccgcatc  tcagactga  ccgaggggc  aaggggatc  gcacgctgc  ctttgccct  5100
atgatgtcc  tgcctgccc  cttcaacat  gggctgctg  tcttcctcg  catgttcat  5160
tactccatc  ttggcatgg  caacttcgc  tatgtcaag  gggaggctg  catcgacga  5220
atgttcaac  tccagacct  cgccaacag  atgctgtgc  tcttccaga  caccacgtc  5280
gccggctgg  atggcctcc  cagccccat  ctcaacact  ggccgccct  ctgcgaccc  5340
actctgccc  acagcaatg  ctctcgggg  gactgcggg  gcccagccg  gggcatcct  5400
ttcttcacc  cctacatca  catctcctt  ctcatcgtg  tcaacatgt  cattgccat  5460
atcctggag  acttcagcg  ggccacgga  gagagcacc  agcccctga  tgaggacga  5520
ttcgatatg  tctatgaga  ctgggagaa  tttgaccca  aggccactc  gtttattga  5580
tattcggtc  tgtctgact  tgccgacgc  ctgtctgag  cactccgta  cgccaagcc  5640
aaccagata  gcctcatca  catggacct  cccatggtg  gtggggacc  catccattg  5700
atggacatt  tctttgcct  caccaaaag  gtcctgggg  agtctgggg  gatggacgc  5760
ctgaagatc  agatggagg  gaagttcat  gcagccaac  catccaaga  ctcctacga  5820
cccatcacc  ccacactcc  gcgcaagca  gaagaggtg  cggccatgg  tatccagag  5880
gccttccgc  ggcacctgc  gcaacgctc  ttgaagcat  cctccttcc  cttccgtca  5940
caggcgggc  gcggcctct  cgaagagga  gcccctgag  gagagggcc  catcgccta  6000
gtgatgagt  agaacttct  ccgacccct  ggcccaccc  ccagctcct  catctcctc  6060
acttccttc  caccctcct  tgacagtgt  actagagcc  ccagcgata  cctccaggt  6120
cgggggtct  actacagcc  cagtgaaga  ctcgccgac  tcccccctt  tccggacag  6180
gaccgtgag  ccatcgtgt  agcctcggc  tggctggcc  ggacacact  aaaagcagc  6240
tttttcacc  tggcaaacc  aaatgcagt  agtcacaaa  cagcctggg  ccttcctgg  6300
tttgggagt  agaaatggg  ctcggcccc  cggatcaac  aggcagagt  ctgtggcgc  6360
gcgtggaca  ccggagcag  tggcctgtg  ttggaggcc  cagatagac  tgtgacctg  6420
tctggtcag  caatgcccc  gcggctctg  aaagcaact  catcccagc  gctgaggcg  6480
aatataaaa  tgagactgt  tatgttgtg  atgggcttt  ataaattta  tatatttga  6540
attttttta  ttgagcaaa  aactaagga  ttttccatg  acatgggca  caattcacg  6600
tgtctcttc  taaccctga  caagagtgt  tatggagca  ccggaagtc  gttctcaaa  6660
cagaagtgg  atccagtgt  gctcccaca  gtcttcact  cccaggggt  gaatggggt  6720
cccctccca  ttgacctga  atgctggga  ggctgaacc  ccactcaca  aagcacaca  6780
acacacagt  ctcacacac  gaggccaga  acaggccgt  ggacccagg  tcccagcct  6840
agggagaca  gcctttccc  gccggcccc  caaggatgg  gttcttgtc  acggggctc  6900
ctctggccc  ctattgtct  ccaaggtcc  attttcccc  ttgtgtttt  acgcaggtc  6960
tattgtcag  cctacaaaa  taaaaggct  ccagaggag  gtggcctgg  gtcccaggg  7020
tgggccnta  gcactgata  ttgcctttt  ttcccctcc  gtaagagta  taacaaaac  7080
aaaggacac  agggtgcaa  ccccattca  ggcctggca  gcagcttgt  cttgctcct  7140
gaacctggc  ggccctgcc  gccagccaa  ggaagagag  ggctgagcc  tgggggttt  7200
gggctaaga  gttcaccag  cctgagcca  ggsnsccct  agcctgcct  aagagagga  7260
actggcgat  tcccagggc  ctctggacc  tacncggag  agttttcnn  tgtggtctc  7320
agctcctct  cagacacag  gacatggga  tggggagcg  acgttggcc  tggccctgt  7380
cagggaaag  gatggtcag  cccagttct  gtgcccctt  gaggggaat  aaccatggc  7440
cctttgaga  agggggcac  gtggtcagg  ccagcctct  tggcnnagt  ccgggatcc  7500
gatggcacc  acacagagg  cctctttgg  gcaagatcc  ggtggntcc  ataggtctt  7560
tgaaaaggc  ttttcaggg  aaaatattt  actagtcca  tcaccccca  gacctcttc  7620
gctgctgac  atcctattt  gcatatgca  atcttttaa  atagagaac  gtcaccctg  7680
ggtaacagg  tcaactggc  aagagcagg  cagggggct  ggctgnncc  ttccagctc  7740
nccacngan  ncctccwmn  nnnnncatn  ctcccaggc  acctcagtc  canctgccg  7800
ctctgggct  gctnctcct  acctacctn  ccgagctgt  ggagggctg  acatttgtg  7860
cagtgctga  nggggcatt  snggcgagt  aagtattak  tttcttctt  tcaccccag  7920
tcccttggt  gcaacccca  acccaaccc  tgcccctga  agatctagt  ctcttctsc  7980
gtgttccct  tgagtccng  gtgggacac  gtttaactg  cccagcgag  tttctccaa  8040
tngaaatcc  atttttgta  atctccatg  tttgnctct  aaggcttgg  gaggtatgt  8100
cccctcctn  gbnctcacc  cctgctaca  aggcaggaa  gcggnttgg  aggcaggtc  8160
ggctssnag  ccagctggc  ggaaggaga  tgtggtttt  gtgtgtgtg  acagcncgg  8220
agctttgag  caggntgcc  ggggctggc  gcagacggt  tggttgggg  tgggaggtg  8280
gctagaccn  ncccttagc  tttagcctg  ctgtcacct  tttaatttc  agaactgca  8340
aatgaccag  aggagggga  aagagagta  gaaaaagga  ggaaggaca  acatcaagt  8400
ccagatgtt  tctgaacta  tcgagcact  ctcaccaaa  ttcnngtat  aataaaata  8460
atannnngg  gcaaaccaa  aaatggctt  c  8491



<210> 10185
<211> 2016
<212> PRT
<213> Homo sapiens
<308> Q14524
<400> 10185

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
  1               5                  10                  15
Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
             20                  25                  30
Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
         35                  40                  45
Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
     50                  55                  60
Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
 65                  70                  75                  80
Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                 85                  90                  95
Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
             100                105                110
Val Leu Ser Pro Phe His Pro Val Arg Arg Ala Ala Val Lys Ile Leu 
         115                120                125
Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
     130                135                140
Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
 145                150                155                160
Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                 165                170                175
Leu Ala Arg Ala Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
             180                185                190
Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
         195                200                205
Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
     210                215                220
Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
 225                230                235                240
Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                 245                250                255
Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
             260                265                270
Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
         275                280                285
Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
     290                295                300
Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
 305                310                315                320
Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                 325                330                335
Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
             340                345                350
Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
         355                360                365
Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
     370                375                380
Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
 385                390                395                400
Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                 405                410                415
Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
             420                425                430
Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
         435                440                445
Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
     450                455                460
Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
 465                470                475                480
Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                 485                490                495
Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
             500                505                510
Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
         515                520                525
Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
     530                535                540
Asp Asp Glu Asn Ser Thr Ala Arg Glu Ser Glu Ser His His Thr Ser 
 545                550                555                560
Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                 565                570                575
Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
             580                585                590
Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
         595                600                605
Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
     610                615                620
Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
 625                630                635                640
Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                 645                650                655
Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
             660                665                670
Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
         675                680                685
Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
     690                695                700
Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
 705                710                715                720
Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                 725                730                735
Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
             740                745                750
Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
         755                760                765
Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
     770                775                780
Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
 785                790                795                800
Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                 805                810                815
Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
             820                825                830
Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
         835                840                845
Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
     850                855                860
Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
 865                870                875                880
Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                 885                890                895
Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
             900                905                910
Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
         915                920                925
Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
     930                935                940
Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
 945                950                955                960
Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                 965                970                975
Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg His Arg Pro Gln Lys Pro 
             980                985                990
Ala Ala Leu Ala Ala Gln Gly Gln Leu Pro Ser Cys Ile Ala Thr Pro 
         995                1000                1005
Tyr Ser Pro Pro Pro Pro Glu Thr Glu Lys Val Pro Pro Thr Arg Lys 
     1010                1015                1020
Glu Thr Gln Phe Glu Glu Gly Glu Gln Pro Gly Gln Gly Thr Pro Gly 
 1025                1030                1035                1040
Asp Pro Glu Pro Val Cys Val Pro Ile Ala Val Ala Glu Ser Asp Thr 
                 1045                1050                1055
Asp Asp Gln Glu Glu Asp Glu Glu Asn Ser Leu Gly Thr Glu Glu Glu 
             1060                1065                1070
Ser Ser Lys Gln Gln Glu Ser Gln Pro Val Ser Gly Trp Pro Arg Gly 
         1075                1080                1085
Pro Pro Asp Ser Arg Thr Trp Ser Gln Val Ser Ala Thr Ala Ser Ser 
     1090                1095                1100
Glu Ala Glu Ala Ser Ala Ser Gln Ala Asp Trp Arg Gln Gln Trp Lys 
 1105                1110                1115                1120
Ala Glu Pro Gln Ala Pro Gly Cys Gly Glu Thr Pro Glu Asp Ser Cys 
                 1125                1130                1135
Ser Glu Gly Ser Thr Ala Asp Met Thr Asn Thr Ala Glu Leu Leu Glu 
             1140                1145                1150
Gln Ile Pro Asp Leu Gly Gln Asp Val Lys Asp Pro Glu Asp Cys Phe 
         1155                1160                1165
Thr Glu Gly Cys Val Arg Arg Cys Pro Cys Cys Ala Val Asp Thr Thr 
     1170                1175                1180
Gln Ala Pro Gly Lys Val Trp Trp Arg Leu Arg Lys Thr Cys Tyr His 
 1185                1190                1195                1200
Ile Val Glu His Ser Trp Phe Glu Thr Phe Ile Ile Phe Met Ile Leu 
                 1205                1210                1215
Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Leu Glu Glu Arg 
             1220                1225                1230
Lys Thr Ile Lys Val Leu Leu Glu Tyr Ala Asp Lys Met Phe Thr Tyr 
         1235                1240                1245
Val Phe Val Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Phe Lys 
     1250                1255                1260
Lys Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile Val Asp 
 1265                1270                1275                1280
Val Ser Leu Val Ser Leu Val Ala Asn Thr Leu Gly Phe Ala Glu Met 
                 1285                1290                1295
Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg 
             1300                1305                1310
Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala Leu Val 
         1315                1320                1325
Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile Phe 
     1330                1335                1340
Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys Phe 
 1345                1350                1355                1360
Gly Arg Cys Ile Asn Gln Thr Glu Gly Asp Leu Pro Leu Asn Tyr Thr 
                 1365                1370                1375
Ile Val Asn Asn Lys Ser Gln Cys Glu Ser Leu Asn Leu Thr Gly Glu 
             1380                1385                1390
Leu Tyr Trp Thr Lys Val Lys Val Asn Phe Asp Asn Val Gly Ala Gly 
         1395                1400                1405
Tyr Leu Ala Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp Ile 
     1410                1415                1420
Met Tyr Ala Ala Val Asp Ser Arg Gly Tyr Glu Glu Gln Pro Gln Trp 
 1425                1430                1435                1440
Glu Tyr Asn Leu Tyr Met Tyr Ile Tyr Phe Val Ile Phe Ile Ile Phe 
                 1445                1450                1455
Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp Asn 
             1460                1465                1470
Phe Asn Gln Gln Lys Lys Lys Leu Gly Gly Gln Asp Ile Phe Met Thr 
         1475                1480                1485
Glu Glu Gln Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser Lys 
     1490                1495                1500
Lys Pro Gln Lys Pro Ile Pro Arg Pro Leu Asn Lys Tyr Gln Gly Phe 
 1505                1510                1515                1520
Ile Phe Asp Ile Val Thr Lys Gln Ala Phe Asp Val Thr Ile Met Phe 
                 1525                1530                1535
Leu Ile Cys Leu Asn Met Val Thr Met Met Val Glu Thr Asp Asp Gln 
             1540                1545                1550
Ser Pro Glu Lys Ile Asn Ile Leu Ala Lys Ile Asn Leu Leu Phe Val 
         1555                1560                1565
Ala Ile Phe Thr Gly Glu Cys Ile Val Lys Leu Ala Ala Leu Arg His 
     1570                1575                1580
Tyr Tyr Phe Thr Asn Ser Trp Asn Ile Phe Asp Phe Val Val Val Ile 
 1585                1590                1595                1600
Leu Ser Ile Val Gly Thr Val Leu Ser Asp Ile Ile Gln Lys Tyr Phe 
                 1605                1610                1615
Phe Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly Arg 
             1620                1625                1630
Ile Leu Arg Leu Ile Arg Gly Ala Lys Gly Ile Arg Thr Leu Leu Phe 
         1635                1640                1645
Ala Leu Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu Leu 
     1650                1655                1660
Phe Leu Val Met Phe Ile Tyr Ser Ile Phe Gly Met Ala Asn Phe Ala 
 1665                1670                1675                1680
Tyr Val Lys Trp Glu Ala Gly Ile Asp Asp Met Phe Asn Phe Gln Thr 
                 1685                1690                1695
Phe Ala Asn Ser Met Leu Cys Leu Phe Gln Ile Thr Thr Ser Ala Gly 
             1700                1705                1710
Trp Asp Gly Leu Leu Ser Pro Ile Leu Asn Thr Gly Pro Pro Tyr Cys 
         1715                1720                1725
Asp Pro Thr Leu Pro Asn Ser Asn Gly Ser Arg Gly Asp Cys Gly Ser 
     1730                1735                1740
Pro Ala Val Gly Ile Leu Phe Phe Thr Thr Tyr Ile Ile Ile Ser Phe 
 1745                1750                1755                1760
Leu Ile Val Val Asn Met Tyr Ile Ala Ile Ile Leu Glu Asn Phe Ser 
                 1765                1770                1775
Val Ala Thr Glu Glu Ser Thr Glu Pro Leu Ser Glu Asp Asp Phe Asp 
             1780                1785                1790
Met Phe Tyr Glu Ile Trp Glu Lys Phe Asp Pro Glu Ala Thr Gln Phe 
         1795                1800                1805
Ile Glu Tyr Ser Val Leu Ser Asp Phe Ala Asp Ala Leu Ser Glu Pro 
     1810                1815                1820
Leu Arg Ile Ala Lys Pro Asn Gln Ile Ser Leu Ile Asn Met Asp Leu 
 1825                1830                1835                1840
Pro Met Val Ser Gly Asp Arg Ile His Cys Met Asp Ile Leu Phe Ala 
                 1845                1850                1855
Phe Thr Lys Arg Val Leu Gly Glu Ser Gly Glu Met Asp Ala Leu Lys 
             1860                1865                1870
Ile Gln Met Glu Glu Lys Phe Met Ala Ala Asn Pro Ser Lys Ile Ser 
         1875                1880                1885
Tyr Glu Pro Ile Thr Thr Thr Leu Arg Arg Lys His Glu Glu Val Ser 
     1890                1895                1900
Ala Met Val Ile Gln Arg Ala Phe Arg Arg His Leu Leu Gln Arg Ser 
 1905                1910                1915                1920
Leu Lys His Ala Ser Phe Leu Phe Arg Gln Gln Ala Gly Ser Gly Leu 
                 1925                1930                1935
Ser Glu Glu Asp Ala Pro Glu Arg Glu Gly Leu Ile Ala Tyr Val Met 
             1940                1945                1950
Ser Glu Asn Phe Ser Arg Pro Leu Gly Pro Pro Ser Ser Ser Ser Ile 
         1955                1960                1965
Ser Ser Thr Ser Phe Pro Pro Ser Tyr Asp Ser Val Thr Arg Ala Thr 
     1970                1975                1980
Ser Asp Asn Leu Gln Val Arg Gly Ser Asp Tyr Ser His Ser Glu Asp 
 1985                1990                1995                2000
Leu Ala Asp Phe Pro Pro Ser Pro Asp Arg Asp Arg Glu Ser Ile Val 
                 2005                2010                2015



<210> 10186
<211> 1693
<212> DNA
<213> Rattus norvegicus
<308> X94246
<400> 10186

gagagctgc  agtgttccg  agctgtgag  gactcccca  cggcgatgc  tcacaactc  60
atcagatcc  gccacggag  gctgaatca  ttaggaggg  cttttgtga  tggcaggcc  120
ctgccagaa  ttgtccggc  acgcattgt  gacttggcc  accagggag  gagaccctg  180
gatatctct  gccagcttc  tgtcagcca  ggctgtgta  gcaagatcc  tggcaggta  240
tacgagact  gcagcatcc  gcctggagt  atagggggc  ccaagccca  ggtggccac  300
cccaaggtg  tggagaaga  aggggacta  aagcggcag  accctacca  gtttgcttg  360
gagatccgg  accggctct  ggcagaagg  gtttgtgac  atgacactg  gcccagtgt  420
agctccatc  acagaatca  ccggaccaa  gtgcagcag  cattcaacc  ccccatgga  480
agctgcgtg  ccaccaaat  tctgagccc  ggacacaca  tgatcccca  ctcagctgt  540
acaccccca  agtcacccc  gtcggattc  ttgggctct  cctactcta  ccacgggct  600
ctagggatt  ctcaggctg  cagtgacac  cacagagga  gatgtgatg  tagtgacca  660
ggacagtgt  gactgagca  cgattccca  agcagcagt  gtggtcctc  aaagcatct  720
cgtacagac  ccttcgggc  gcaccacct  gagccgctc  agtgcccgt  tgagcggca  780
cattacccg  aggcctatg  ctcccccag  cacaccaaa  gcgagcagg  gctataccc  840
ctgccctta  tcaacagta  cctggatga  ggaaaggcc  ccctgacac  ttccaatac  900
cctctggga  gcaacctct  aactcacca  acctaccct  tggtggcag  tcctcattc  960
ccctacgcc  taaagcagg  aaccccaga  ctctccagt  ctagctcca  cccttcctc  1020
ttatctagc  ccgcctttt  ggatctgca  caagtcggc  ctgggggcc  agcaggtgc  1080
tcggtccca  ccttcaatg  cttttccca  gctgcctcc  tgtatgggc  gttcacggg  1140
caggccctc  tctcagggc  agagatggt  gggccatcg  tgcctggat  cccacccca  1200
atccccacc  gtggacagg  cagctatgc  tcttccgct  ttgcaggca  ggtggcagg  1260
agtgagtat  ctggcaatg  ctacagcca  accccgtac  cctcctaca  tgaggcctg  1320
cgcttcccc  actccagcc  gctgagttc  ccatattat  acagctcta  aacaaggcc  1380
agcgcaccg  ccacctctg  cacggcctt  gaccatctg  agttgtcat  gggacagtg  1440
gaacaacca  gcaacagga  gacttggcc  gagacgggc  ccagagagt  acacaaagg  1500
atctttatt  attacatga  aaataacca  aattccagc  ttgccgctc  ctccctgtg  1560
ggtcaatta  atgaaccat  aaagtcagg  tgaccttgg  gaaggccaa  ctgtcctcc  1620
agagtcatt  cgtgatgtg  caggagttc  aggaaccaa  aaccatcca  ttcaaaaga  1680
cacggagga  aaa  1693



<210> 10187
<211> 458
<212> PRT
<213> Rattus norvegicus
<308> P51974
<400> 10187

Met Pro His Asn Ser Ile Arg Ser Gly His Gly Gly Leu Asn Gln Leu 
  1               5                  10                  15
Gly Gly Ala Phe Val Asn Gly Arg Pro Leu Pro Glu Val Val Arg Gln 
             20                  25                  30
Arg Ile Val Asp Leu Ala His Gln Gly Val Arg Pro Cys Asp Ile Ser 
         35                  40                  45
Arg Gln Leu Arg Val Ser His Gly Cys Val Ser Lys Ile Leu Gly Arg 
     50                  55                  60
Tyr Tyr Glu Thr Gly Ser Ile Arg Pro Gly Val Ile Gly Gly Ser Lys 
 65                  70                  75                  80
Pro Lys Val Ala Thr Pro Lys Val Val Glu Lys Ile Gly Asp Tyr Lys 
                 85                  90                  95
Arg Gln Asn Pro Thr Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu 
             100                105                110
Ala Glu Gly Val Cys Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile 
         115                120                125
Asn Arg Ile Ile Arg Thr Lys Val Gln Gln Pro Phe Asn Leu Pro Met 
     130                135                140
Asp Ser Cys Val Ala Thr Lys Ser Leu Ser Pro Gly His Thr Leu Ile 
 145                150                155                160
Pro Ser Ser Ala Val Thr Pro Pro Glu Ser Pro Gln Ser Asp Ser Leu 
                 165                170                175
Gly Ser Thr Tyr Ser Ile His Gly Leu Leu Gly Ile Ala Gln Ala Gly 
             180                185                190
Ser Asp Thr His Arg Gly Arg Cys Asp Asp Ser Asp Gln Gly Gln Cys 
         195                200                205
Arg Leu Ser Ile Asp Ser Gln Ser Ser Ser Ser Gly Pro Arg Lys His 
     210                215                220
Leu Arg Thr Asp Thr Phe Gly Gln His His Leu Glu Pro Leu Glu Cys 
 225                230                235                240
Pro Phe Glu Arg Gln His Tyr Pro Glu Ala Tyr Ala Ser Pro Ser His 
                 245                250                255
Thr Lys Gly Glu Gln Gly Leu Tyr Pro Leu Pro Leu Leu Asn Ser Thr 
             260                265                270
Leu Asp Asp Gly Lys Ala Thr Leu Thr Pro Ser Asn Thr Pro Leu Gly 
         275                280                285
Arg Asn Leu Ser Thr His Gln Thr Tyr Pro Val Val Ala Asp Pro His 
     290                295                300
Ser Pro Tyr Ala Ile Lys Gln Glu Thr Pro Glu Leu Ser Ser Ser Ser 
 305                310                315                320
Ser Thr Pro Ser Ser Leu Ser Ser Ser Ala Phe Leu Asp Leu Gln Gln 
                 325                330                335
Val Gly Ser Gly Gly Pro Ala Gly Ala Ser Val Pro Pro Phe Asn Ala 
             340                345                350
Phe Ser His Ala Ala Ser Val Tyr Gly Gln Phe Thr Gly Gln Ala Leu 
         355                360                365
Leu Ser Gly Arg Glu Met Val Gly Pro Ser Leu Pro Gly Tyr Pro Pro 
     370                375                380
His Ile Pro Thr Ser Gly Gln Gly Ser Tyr Ala Ser Ser Ala Ile Ala 
 385                390                395                400
Gly Met Val Ala Gly Ser Glu Tyr Ser Gly Asn Ala Tyr Ser His Thr 
                 405                410                415
Pro Tyr Ala Ser Tyr Ser Glu Ala Trp Arg Phe Pro Asn Ser Ser Leu 
             420                425                430
Leu Ser Ser Pro Tyr Tyr Tyr Ser Ser Thr Thr Arg Pro Ser Ala Pro 
         435                440                445
Pro Thr Ser Ala Thr Ala Phe Asp His Leu 
     450                455



<210> 10188
<211> 2757
<212> DNA
<213> Homo sapiens
<308> AK023855
<400> 10188

gcacacttc  atttgtttg  atgtggaga  agaaaagaa  aaatccacg  ggtgggtaa  60
gcacctggg  ccacagccg  aaaatcccg  gtttagtct  tttcactat  caaaattgg  120
ccatttacc  gagttccag  ctccacata  aaaacacag  cataatatt  ctcacccat  180
tcactgggc  gctggggga  tctactagg  caacagagg  aaagctctg  tataagctc  240
ttgcaaatg  aagaagtgg  ccttatgtc  cccagttta  ggcagtggt  gagagcaga  300
acattctga  ccctcgaat  tgaatccta  ctttggccc  tctggaagt  ggacaagtt  360
cttaaacct  tgtgcctgg  tttcctatc  ggggaagaa  aaattaaca  atgcaagga  420
cctgaacag  ccggttgga  actgctcca  tccttggca  cgtcctgca  tctgtgggt  480
ccaacagtg  ggtgaaacc  ggaagccga  cagccatcc  accagggtg  ggtcctctg  540
ctgagactc  ctatcccac  tctgggcac  catgccacc  gctggcctt  aattccagg  600
atgcgggag  acaatgagc  tgaacgaaa  gtgccgagt  gagttgaga  cgtaaagga  660
gaaggggga  atgaggacc  ctcctgggg  gatgagggc  gccaagtcc  aagacacag  720
ctcagggtc  gcaggaagg  cggcttgtt  gatcgtctc  gtgcgctga  ttctctttg  780
tccccaggg  ctctacccg  tgcccttgc  caacagcac  ctggacgac  ggaaggcca  840
cctgacccc  tccaacacg  cactggggc  caacctctc  actcaccag  cctaccccg  900
ggtggcaga  cctcactca  ccttcgcca  aaagcagga  acccccgag  tgtccagtt  960
tagctccac  ccttcctct  tatctagct  cgccttttt  gatctgcag  aagtcggct  1020
cggggtccc  cccttcaat  cctttcccc  tgctgcctc  gtgtacggg  agttcacgg  1080
ccaggccct  ctctcaggg  gagagatgg  ggggcccac  ctgcccgga  acccacccc  1140
catccccac  agcggacag  gcagctatg  ctcctccgc  atcgcaggc  tggtggcag  1200
taaggagag  gccggcagg  aggggagca  tgcaaagag  aagtattgg  gcaaggtgg  1260
acacaagga  caagaggca  actgtgccc  attcataga  ttcccaaag  gcattgaag  1320
atggaccaa  gagggcatc  ccttgtaaa  gcctggaga  gatgtccca  tgcagtcct  1380
actccctat  taacttgcc  cagctcggc  tccttcttc  caggcctgc  acattaccc  1440
ccatgatga  aagggaggg  ctgagacag  tctgtgttc  aatccaagc  ccaccactt  1500
ttccagtga  tcagtgagc  taaatggag  gcactctaa  ggccccaaa  cactgtgag  1560
ggaagatga  ccctaccct  aagcagtgc  ggtctccca  tgatttaac  ctgatgaat  1620
ccagtttac  cgttctgta  aatctgaat  tgaagggta  tgatgatga  gatgatgat  1680
atgacgatg  cgatgatga  gatgaaata  atgcttcac  tctctctct  aagcctgca  1740
ggataggac  cgggttcta  gtactctaa  agtactata  aggatgaaa  gagcctgga  1800
tagctctcc  tcctcattt  gactgttct  gaacctgcc  gccagtcat  tgggtttct  1860
tgtctgcca  tcatcatcc  atgatgatt  aagatgata  ggtctggac  aatgaagat  1920
atgggagtt  ccttgggca  gtctcaatt  tttaggagc  atgtaggga  gactttggg  1980
tggatgaga  ataattgag  cattgtcac  ggtcaaaaa  gcctgggac  tggagtttc  2040
ggaaagagc  ctgaacaca  ggcatctgt  acccccatg  cagccctag  ccagcctct  2100
tggctgtga  cccagagac  tggcgtatt  acctaggcc  gcttccctt  cttgccggc  2160
ggagttaat  tttgccagc  acccactct  ggcacccta  gcagaggca  gtgggctgg  2220
atctcctgg  cagagggaa  ggagggaga  aaagaggga  ggagaaatg  tctgtgctc  2280
ctgggaacc  gctgagctg  cacttgttg  tgcctggtt  ccgtggcga  gtgcttaat  2340
cagcgttga  aatacagaa  actgactcc  ctgtccctc  tggccccgg  ctccctccc  2400
ccctccctt  ctcttctgg  gcgtgaaat  agattggtc  agataaaaa  ggaaaagat  2460
cggttattt  tttaagagt  tggataatg  ggcctctca  tcaaaatcc  agtctccag  2520
cggttcccc  cattcccct  ccaacccct  caccttccc  tgccgcctg  ttagaggag  2580
aggaagaaa  ataaagcac  aggcttttc  cttaattat  aatcattcc  tgagggcag  2640
cccagggca  ggggttcct  gggcccaga  tctgacctg  gaggtagct  gaaggcttg  2700
gcctctcat  aaagtcccc  aggttgttt  cagaaagaa  cctgagtgg  ttctgtg  2757



<210> 10189
<211> 463
<212> DNA
<213> Rattus norvegicus
<308> X95850
<400> 10189

tttaggcat  aaggggtat  ttaatccat  gccacatac  attcctata  ttacatata  60
ggagtgaac  gtgaaccag  tagaaacct  tatctagtt  ccaacgagt  ccactggag  120
aaagaaact  cacaagttg  agaactgag  aattagctt  cttccagtg  gacgcggta  180
acggaggtg  tctcgagcg  gtgagcttc  tcctttcgc  aacgctaat  cagtagtag  240
aatcaatct  gtcctctct  gtaaacatc  gctggtggt  cagagctct  agccagtca  300
gctgctgtc  aggttctaa  agctgtttg  ggactcagt  accattgca  gtggacacc  360
tacccgact  gaaataaac  ttttccctg  tctcctgat  ccccgttcc  tctttctgc  420
aacacatct  aggagtaag  ctttaaacc  ttgatctcc  aca  463



<210> 10190
<211> 826
<212> DNA
<213> Rattus norvegicus
<308> X96394
<400> 10190

cagaaggtg  agagaatct  agtgtgggg  agcgacagc  tgtgtgcct  gcccgggct  60
tgctgagga  gacaaagat  ctagtgttg  acgaggcta  agcagctgt  gatctggag  120
cagatgacc  tattcagtc  accatccgg  cgcagtttg  agacagtac  gtgctcact  180
ttgctcatc  gctgaatac  ataatggac  atacaaggg  gattgtcct  gacaaagga  240
aaattcggg  gtgtggtgc  ccctctgag  tcctgcagc  aagaggcgt  ttctatagc  300
tggccaagg  tgctggctt  gtgtgaact  atctctggc  tatctgatg  ggactgcag  360
gccaggatc  cagtgtcca  gcatgagcc  gcaaccctg  aaacctaca  tccccagag  420
aaaaccaaa  attgaaaga  aaccaaact  aaaggaagc  aaacacata  agcatcagt  480
acagtttgc  ccagcctgg  tctgacctc  aagaagcct  aagacagat  tgccccact  540
caaacacgt  tggcttctg  caccacttg  gaggctccc  gaaagttca  ccatgctcc  600
gctgtatcc  aaagcaagg  catgagcag  caaacacac  agtgaccaa  cacaagcca  660
tgcctcatg  ctattcagc  acatttata  agccaagcc  gagcctctc  gccctgcca  720
ctcttctgt  tcctacagt  ctgttggtg  cagaagagt  tatcttgcc  tcaggtctt  780
cagttgaaa  catggaaac  aaaacaaac  aacaaaaaa  aaaaaa  826



<210> 10191
<211> 107
<212> PRT
<213> Rattus norvegicus
<308> CAA65258
<400> 10191

Glu Gly Gly Glu Asn Leu Ser Val Gly Gln Arg Gln Leu Val Cys Leu 
  1               5                  10                  15
Ala Arg Ala Leu Leu Arg Lys Thr Lys Ile Leu Val Leu Asp Glu Ala 
             20                  25                  30
Thr Ala Ala Val Asp Leu Glu Thr Asp Asp Leu Ile Gln Ser Thr Ile 
         35                  40                  45
Arg Thr Gln Phe Glu Asp Ser Thr Val Leu Thr Ile Ala His Arg Leu 
     50                  55                  60
Asn Thr Ile Met Asp Tyr Thr Arg Val Ile Val Leu Asp Lys Gly Glu 
 65                  70                  75                  80
Ile Arg Glu Cys Gly Ala Pro Ser Glu Leu Leu Gln Gln Arg Gly Val 
                 85                  90                  95
Phe Tyr Ser Met Ala Lys Asp Ala Gly Leu Val 
             100                105



<210> 10192
<211> 5732
<212> DNA
<213> Homo sapiens
<308> NM_019900
<400> 10192

ccaggcggc  ttgcggccc  ggccccggc  ccctgcgcc  ccgccgccg  cgccgccgc  60
gccgccgcc  ccgccgcca  cgctagcgc  agcagccgg  cccgatcac  cgccgcccg  120
tgcccgccg  cgcccgcgc  agcaaccgg  cccgatcac  cgccgcccg  tgcccgccg  180
cgcccgcgc  accggcatg  cgctccggg  cttctgcag  gccgatggc  ccgacccgc  240
ctgggactg  aatgtcacg  ggaatacca  caaccccga  ttcaccaag  gctttcaga  300
cacggtcct  gtgtgggtg  cttgttttt  cctctgggc  tgtttcccc  tctacttcc  360
ctatctctc  cgacatgac  gaggctaca  tcagatgac  cctctcaac  aaaccaaaa  420
tgccttggg  tttttgctg  ggatcgtct  ctgggcaga  ctcttctac  ctttctggg  480
aagaagtcg  ggcatattc  tggccccag  gtttctggt  agcccaact  tcttgggca  540
caccacgct  cttgctacc  ttttaattc  gctggagag  aggaaggga  ttcagtctt  600
agggatcat  ctcactttc  ggctggtag  cctagtgtg  gccctagcc  tcctgagat  660
caaaattat  acagcctta  aagaggatg  ccaggtgga  ctgtttcgt  acatcactt  720
ctacgtcta  ttttccctc  tactcattc  gctcgtctt  tcctgtttc  cagatcgct  780
acccctgtt  tcggaaacc  tccacgacc  taatccctg  ccagagtcc  gcgcttcct  840
cctgtcgag  atcaccttc  ggtggatca  agggttgat  gtccggggc  accgccagc  900
cctggaggg  agtgacctc  ggtccttaa  caaggagga  acgtcggaa  aagtcgtgc  960
tgttttggt  aagaactgg  agaaggaat  cgccaagac  aggaagcag  cggtgaagg  1020
tgtgtactc  tccaaggat  ctgcccagc  gaaagagag  tccaaggtg  atgcgaatg  1080
ggaggtgga  gctttgatc  tcaagtccc  acagaagga  tggaacccc  ctctgttta  1140
ggtgttata  aagaccttt  ggccctact  cctcatgag  ttcttcttc  aggccatcc  1200
cgacctgat  atgttttcc  ggccgcaga  cttaaagtt  ctcatcaag  tcgtgaatg  1260
cacgaaggc  ccagactgg  agggctact  ctacaccgt  ctgctgttt  tcactgcct  1320
cctgcagac  ctcgtgctg  accagtact  ccacatctg  ttcgtcagt  gcatgagga  1380
caagaccgc  gtcattggg  ctgtctatc  gaaggccct  gtgatcacc  attcagcca  1440
aaaatcctc  acggtcggg  agattgtca  cctcatgtc  gtggacgct  agaggttca  1500
ggacttggc  acgtacatt  acatgatct  gtcagcccc  ctgcaagtc  tccttgctc  1560
ctacctcct  tggctgaat  tgggccctt  cgtcctggc  ggagtggcg  tgatggtcc  1620
catggtgcc  gtcaatgct  tgatggcga  gaagaccaa  acgtatcag  tggcccaca  1680
gaagagcaa  gacaatcgg  tcaagctga  gaacgaaat  ctcaatggg  tcaaagtgc  1740
aaagcttta  gcctgggag  tggcattca  ggacaaggt  ctggccatc  ggcaggagg  1800
gctgaaggt  ctgaagaag  ctgcctacc  gtcagccgt  ggcaccttc  cctgggtct  1860
cacgccctt  ctggtggcc  tgtgcacat  tgccgtcta  gtgaccatt  acgagaaca  1920
catcctgga  gcccagaca  ccttcgtgt  tttggcctt  ttcaacatc  tccggtttc  1980
cctgaacat  ctccccatg  tcatcagca  catcgtgca  gcgagtgtc  ccctcaaac  2040
cctgaggat  tttctctcc  atgaggagc  ggaacctga  agcatcgag  gacggcctg  2100
caaagacgg  gggggcacg  acagcatca  cgtgaggaa  gccacattc  cctgggcca  2160
gagcgaccc  cccacactg  atggcatca  cttctccat  cccgaaggt  ctttggtgg  2220
cgtggtggg  caggtgggc  gcggaaagt  gtccctgct  tcagccctc  tggctgaga  2280
ggacaaagt  gaggggcac  tggctatca  gggctccgt  gcctatgtg  cacagcagg  2340
ctggattca  aatgattct  tccgagaaa  catcctttt  ggatgtcag  tggaggaac  2400
atattacag  tccgtgata  aggcctgtg  cctcctccc  gacctggaa  tcctgccca  2460
tggggatcg  acagagatt  gcgagaagg  cgtgaacct  tctgggggc  agaagcagc  2520
cgtgagcct  gcccgggcc  tgtactcca  cgctgacat  tacctcttc  atgatcccc  2580
ctcagcagt  gatgcccat  tgggaaaac  catctttga  aatgtgatt  gccccaagg  2640
gatgctgaa  aacaagacg  ggatcttgg  cacgcacag  atgagctac  tgccgcagg  2700
ggacgtcat  atcgtcatg  gtggcggca  gatctctga  atgggctcc  accaggagc  2760
gctggctcg  gacggcgcc  tcgctgagt  cctgcgtac  tatgccagc  cagagcagg  2820
gcaggatgc  gaggagaac  gggtcacgg  cgtcagcgg  ccagggaag  aagcaaagc  2880
aatggagaa  ggcatgctg  tgacggaca  tgcagggaa  caactgcag  gacagctca  2940
cagctcctc  tcctatagt  gggacatca  caggcacca  aacagcacc  cagaactgc  3000
gaaagctga  gccaagaag  aggagacct  gaagctgat  gaggctgac  aggcgcaga  3060
agggcaggt  aagctttcc  tgtactggg  ctacatgaa  gccatcgga  tcttcatct  3120
cttcctcag  atcttcctt  tcatgtgta  ccatgtgtc  gcgctggct  ccaactatt  3180
gctcagcct  tggactgat  accccatcg  caacgggac  caggagcac  cgaaagtcc  3240
gctgagcgt  tatggagcc  tgggcattt  acaagggat  gccgtgttt  gctactcca  3300
ggccgtgtc  atcgggggg  tcttggctt  ccgctgtct  cacgtggac  tgctgcaca  3360
catcctgcg  tcacccatg  gcttctttg  gcggacccc  agtgggaac  tggtgaacc  3420
cttctccaa  gagctggac  cagtggact  catgatccc  gaggtcatc  agatgttca  3480
gggctccct  ttcaacgtc  ttggtgcct  catcgttat  ctgctggcc  cgcccatcg  3540
cgccatcat  atcccgccc  ttggcctca  ctacttctt  gtccagagg  tctacgtgg  3600
ttcctcccg  cagctgaag  gcctcgagt  ggtcagccg  tccccggtc  attcccatt  3660
caacgagac  ttgctgggg  tcagcgtca  tcgagcctt  gaggagcag  agcgcttca  3720
ccaccagag  gacctgaag  tggacgaga  ccagaaggc  tattacccc  gcatcgtgg  3780
caacaggtg  ctggccgtg  ggctggagt  tgtgggcaa  tgcatcgtt  tgtttgctg  3840
cctgtttgc  gtgatctcc  ggcacagcc  cagtgctgg  ttggtgggc  tctcagtgt  3900
ttactcatt  caggtcacc  cgtacttga  ctggctggt  cggatgtca  ctgaaatgg  3960
aaccaacat  gtggccgtg  agaggctca  ggagtattc  gagactgag  aggaggcgc  4020
ctggcaaat  caggagaca  ctccgccca  cagctggcc  caggtgggc  gagtggaat  4080
ccggaacta  tgcctgcgc  accgagagg  cctggactt  gttctcagg  acatcaatg  4140
cacgatcaa  gggggagaa  aggtcggca  cgtggggcg  acgggagct  ggaagtcgt  4200
cctgaccct  ggcttattt  ggatcaacg  gtctgccga  ggagagatc  tcatcgatg  4260
catcaacat  gccaagatc  gcctgcacg  cctccgctt  aagatcacc  tcatccccc  4320
ggaccctgt  ttgttttcg  gttccctcc  aatgaacct  gacccattc  gccagtact  4380
ggatgaaga  gtctggacg  ccctggagc  ggcccacct  aaggacttc  tgtcagccc  4440
tcctgacaa  ctagaccat  aatgtgcag  aggcgggga  aacctcagg  tgatcgtct  4500
ggacaaagg  gaaatccag  agtacggcg  cccatcgga  ctcctgcag  agagaggtc  4560
tttctacag  atggccaaa  acgccggct  ggtgtgagc  ccagagctg  catatctgg  4620
cagaactgc  gggcctata  gccagcgcc  agggaggag  cagtacccc  ggtaaacca  4680
gcctcccac  ctgaaacca  aacataaaa  ccaaaccca  acaaccaaa  catattcaa  4740
gcagcagcc  ccgccatcc  gtcccctgc  tggaactgg  tgtgaagac  caggagaga  4800
agagatgcg  accacccaa  acacgcaca  cctgcccct  gtgccctga  acagacaca  4860
agcctcacg  ccccaggaa  gcaagtggt  tcctggtgc  tcccacgga  gagttttgg  4920
agccagact  ctggaggaa  tggttgtat  gaagatcct  gtgaccaaa  tcagcctac  4980
gcctcggat  tctccagcc  aagtctgtg  actgcaagt  tttgagatg  ttctggctc  5040
catcacctc  aacatcctt  tctgggtct  ccaggaacg  ttcatttcc  tggggctgc  5100
gttttgtgg  tgaggggcc  ggagaaaat  attttctcc  cttggcagt  tcccagggc  5160
ctggatggt  ctcttacca  catctggtc  tccaggcac  caaaagctg  gaaccagca  5220
ctcagcgcc  gctctacca  ttctcgttt  gggccagag  cagcctctg  actcccacg  5280
ctgtcctcc  ggaagggac  tggttggac  aacggctaa  ctggacctg  aactgtagg  5340
ccaggggat  gtctcaggg  cgacgttcc  cctggggct  ccctcccca  ccaccccga  5400
tccaggctt  ccctttttt  ttttgttca  cattgtaag  acaatcaat  ctgttatta  5460
tgatcccac  atgattgat  tggggtaaa  attaaggag  tggcctcat  ggaatttga  5520
cttgactag  aatagagac  gagagtgag  aaccagctg  aaggtacta  gccagtcct  5580
gcagaaaaa  gtgttaggg  cctggccca  agcagtgtt  gttgcttac  gtgttgatt  5640
attttgttc  tttttctta  cacctcttt  ctttccctc  catggtacc  gctcatggt  5700
atgaagctt  caaagtaaa  aacacgaaa  ac  5732



<210> 10193
<211> 1531
<212> PRT
<213> Homo sapiens
<308> P33527
<400> 10193

Met Ala Leu Arg Gly Phe Cys Ser Ala Asp Gly Ser Asp Pro Leu Trp 
  1               5                  10                  15
Asp Trp Asn Val Thr Trp Asn Thr Ser Asn Pro Asp Phe Thr Lys Cys 
             20                  25                  30
Phe Gln Asn Thr Val Leu Val Trp Val Pro Cys Phe Tyr Leu Trp Ala 
         35                  40                  45
Cys Phe Pro Phe Tyr Phe Leu Tyr Leu Ser Arg His Asp Arg Gly Tyr 
     50                  55                  60
Ile Gln Met Thr Pro Leu Asn Lys Thr Lys Thr Ala Leu Gly Phe Leu 
 65                  70                  75                  80
Leu Trp Ile Val Cys Trp Ala Asp Leu Phe Tyr Ser Phe Trp Glu Arg 
                 85                  90                  95
Ser Arg Gly Ile Phe Leu Ala Pro Val Phe Leu Val Ser Pro Thr Leu 
             100                105                110
Leu Gly Ile Thr Thr Leu Leu Ala Thr Phe Leu Ile Gln Leu Glu Arg 
         115                120                125
Arg Lys Gly Val Gln Ser Ser Gly Ile Met Leu Thr Phe Trp Leu Val 
     130                135                140
Ala Leu Val Cys Ala Leu Ala Ile Leu Arg Ser Lys Ile Met Thr Ala 
 145                150                155                160
Leu Lys Glu Asp Ala Gln Val Asp Leu Phe Arg Asp Ile Thr Phe Tyr 
                 165                170                175
Val Tyr Phe Ser Leu Leu Leu Ile Gln Leu Val Leu Ser Cys Phe Ser 
             180                185                190
Asp Arg Ser Pro Leu Phe Ser Glu Thr Ile His Asp Pro Asn Pro Cys 
         195                200                205
Pro Glu Ser Ser Ala Ser Phe Leu Ser Arg Ile Thr Phe Trp Trp Ile 
     210                215                220
Thr Gly Leu Ile Val Arg Gly Tyr Arg Gln Pro Leu Glu Gly Ser Asp 
 225                230                235                240
Leu Trp Ser Leu Asn Lys Glu Asp Thr Ser Glu Gln Val Val Pro Val 
                 245                250                255
Leu Val Lys Asn Trp Lys Lys Glu Cys Ala Lys Thr Arg Lys Gln Pro 
             260                265                270
Val Lys Val Val Tyr Ser Ser Lys Asp Pro Ala Gln Pro Lys Glu Ser 
         275                280                285
Ser Lys Val Asp Ala Asn Glu Glu Val Glu Ala Leu Ile Val Lys Ser 
     290                295                300
Pro Gln Lys Glu Trp Asn Pro Ser Leu Phe Lys Val Leu Tyr Lys Thr 
 305                310                315                320
Phe Gly Pro Tyr Phe Leu Met Ser Phe Phe Phe Lys Ala Ile His Asp 
                 325                330                335
Leu Met Met Phe Ser Gly Pro Gln Ile Leu Lys Leu Leu Ile Lys Phe 
             340                345                350
Val Asn Asp Thr Lys Ala Pro Asp Trp Gln Gly Tyr Phe Tyr Thr Val 
         355                360                365
Leu Leu Phe Val Thr Ala Cys Leu Gln Thr Leu Val Leu His Gln Tyr 
     370                375                380
Phe His Ile Cys Phe Val Ser Gly Met Arg Ile Lys Thr Ala Val Ile 
 385                390                395                400
Gly Ala Val Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Ala Arg Lys 
                 405                410                415
Ser Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp Ala Gln 
             420                425                430
Arg Phe Met Asp Leu Ala Thr Tyr Ile Asn Met Ile Trp Ser Ala Pro 
         435                440                445
Leu Gln Val Ile Leu Ala Leu Tyr Leu Leu Trp Leu Asn Leu Gly Pro 
     450                455                460
Ser Val Leu Ala Gly Val Ala Val Met Val Leu Met Val Pro Val Asn 
 465                470                475                480
Ala Val Met Ala Met Lys Thr Lys Thr Tyr Gln Val Ala His Met Lys 
                 485                490                495
Ser Lys Asp Asn Arg Ile Lys Leu Met Asn Glu Ile Leu Asn Gly Ile 
             500                505                510
Lys Val Leu Lys Leu Tyr Ala Trp Glu Leu Ala Phe Lys Asp Lys Val 
         515                520                525
Leu Ala Ile Arg Gln Glu Glu Leu Lys Val Leu Lys Lys Ser Ala Tyr 
     530                535                540
Leu Ser Ala Val Gly Thr Phe Thr Trp Val Cys Thr Pro Phe Leu Val 
 545                550                555                560
Ala Leu Cys Thr Phe Ala Val Tyr Val Thr Ile Asp Glu Asn Asn Ile 
                 565                570                575
Leu Asp Ala Gln Thr Ala Phe Val Ser Leu Ala Leu Phe Asn Ile Leu 
             580                585                590
Arg Phe Pro Leu Asn Ile Leu Pro Met Val Ile Ser Ser Ile Val Gln 
         595                600                605
Ala Ser Val Ser Leu Lys Arg Leu Arg Ile Phe Leu Ser His Glu Glu 
     610                615                620
Leu Glu Pro Asp Ser Ile Glu Arg Arg Pro Val Lys Asp Gly Gly Gly 
 625                630                635                640
Thr Asn Ser Ile Thr Val Arg Asn Ala Thr Phe Thr Trp Ala Arg Ser 
                 645                650                655
Asp Pro Pro Thr Leu Asn Gly Ile Thr Phe Ser Ile Pro Glu Gly Ala 
             660                665                670
Leu Val Ala Val Val Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu 
         675                680                685
Ser Ala Leu Leu Ala Glu Met Asp Lys Val Glu Gly His Val Ala Ile 
     690                695                700
Lys Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Asp 
 705                710                715                720
Ser Leu Arg Glu Asn Ile Leu Phe Gly Cys Gln Leu Glu Glu Pro Tyr 
                 725                730                735
Tyr Arg Ser Val Ile Gln Ala Cys Ala Leu Leu Pro Asp Leu Glu Ile 
             740                745                750
Leu Pro Ser Gly Asp Arg Thr Glu Ile Gly Glu Lys Gly Val Asn Leu 
         755                760                765
Ser Gly Gly Gln Lys Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser 
     770                775                780
Asn Ala Asp Ile Tyr Leu Phe Asp Asp Pro Leu Ser Ala Val Asp Ala 
 785                790                795                800
His Val Gly Lys His Ile Phe Glu Asn Val Ile Gly Pro Lys Gly Met 
                 805                810                815
Leu Lys Asn Lys Thr Arg Ile Leu Val Thr His Ser Met Ser Tyr Leu 
             820                825                830
Pro Gln Val Asp Val Ile Ile Val Met Ser Gly Gly Lys Ile Ser Glu 
         835                840                845
Met Gly Ser Tyr Gln Glu Leu Leu Ala Arg Asp Gly Ala Phe Ala Glu 
     850                855                860
Phe Leu Arg Thr Tyr Ala Ser Thr Glu Gln Glu Gln Asp Ala Glu Glu 
 865                870                875                880
Asn Gly Val Thr Gly Val Ser Gly Pro Gly Lys Glu Ala Lys Gln Met 
                 885                890                895
Glu Asn Gly Met Leu Val Thr Asp Ser Ala Gly Lys Gln Leu Gln Arg 
             900                905                910
Gln Leu Ser Ser Ser Ser Ser Tyr Ser Gly Asp Ile Ser Arg His His 
         915                920                925
Asn Ser Thr Ala Glu Leu Gln Lys Ala Glu Ala Lys Lys Glu Glu Thr 
     930                935                940
Trp Lys Leu Met Glu Ala Asp Lys Ala Gln Thr Gly Gln Val Lys Leu 
 945                950                955                960
Ser Val Tyr Trp Asp Tyr Met Lys Ala Ile Gly Leu Phe Ile Ser Phe 
                 965                970                975
Leu Ser Ile Phe Leu Phe Met Cys Asn His Val Ser Ala Leu Ala Ser 
             980                985                990
Asn Tyr Trp Leu Ser Leu Trp Thr Asp Asp Pro Ile Val Asn Gly Thr 
         995                1000                1005
Gln Glu His Thr Lys Val Arg Leu Ser Val Tyr Gly Ala Leu Gly Ile 
     1010                1015                1020
Ser Gln Gly Ile Ala Val Phe Gly Tyr Ser Met Ala Val Ser Ile Gly 
 1025                1030                1035                1040
Gly Ile Leu Ala Ser Arg Cys Leu His Val Asp Leu Leu His Ser Ile 
                 1045                1050                1055
Leu Arg Ser Pro Met Ser Phe Phe Glu Arg Thr Pro Ser Gly Asn Leu 
             1060                1065                1070
Val Asn Arg Phe Ser Lys Glu Leu Asp Thr Val Asp Ser Met Ile Pro 
         1075                1080                1085
Glu Val Ile Lys Met Phe Met Gly Ser Leu Phe Asn Val Ile Gly Ala 
     1090                1095                1100
Cys Ile Val Ile Leu Leu Ala Thr Pro Ile Ala Ala Ile Ile Ile Pro 
 1105                1110                1115                1120
Pro Leu Gly Leu Ile Tyr Phe Phe Val Gln Arg Phe Tyr Val Ala Ser 
                 1125                1130                1135
Ser Arg Gln Leu Lys Arg Leu Glu Ser Val Ser Arg Ser Pro Val Tyr 
             1140                1145                1150
Ser His Phe Asn Glu Thr Leu Leu Gly Val Ser Val Ile Arg Ala Phe 
         1155                1160                1165
Glu Glu Gln Glu Arg Phe Ile His Gln Ser Asp Leu Lys Val Asp Glu 
     1170                1175                1180
Asn Gln Lys Ala Tyr Tyr Pro Ser Ile Val Ala Asn Arg Trp Leu Ala 
 1185                1190                1195                1200
Val Arg Leu Glu Cys Val Gly Asn Cys Ile Val Leu Phe Ala Ala Leu 
                 1205                1210                1215
Phe Ala Val Ile Ser Arg His Ser Leu Ser Ala Gly Leu Val Gly Leu 
             1220                1225                1230
Ser Val Ser Tyr Ser Leu Gln Val Thr Thr Tyr Leu Asn Trp Leu Val 
         1235                1240                1245
Arg Met Ser Ser Glu Met Glu Thr Asn Ile Val Ala Val Glu Arg Leu 
     1250                1255                1260
Lys Glu Tyr Ser Glu Thr Glu Lys Glu Ala Pro Trp Gln Ile Gln Glu 
 1265                1270                1275                1280
Thr Ala Pro Pro Ser Ser Trp Pro Gln Val Gly Arg Val Glu Phe Arg 
                 1285                1290                1295
Asn Tyr Cys Leu Arg Tyr Arg Glu Asp Leu Asp Phe Val Leu Arg His 
             1300                1305                1310
Ile Asn Val Thr Ile Asn Gly Gly Glu Lys Val Gly Ile Val Gly Arg 
         1315                1320                1325
Thr Gly Ala Gly Lys Ser Ser Leu Thr Leu Gly Leu Phe Arg Ile Asn 
     1330                1335                1340
Glu Ser Ala Glu Gly Glu Ile Ile Ile Asp Gly Ile Asn Ile Ala Lys 
 1345                1350                1355                1360
Ile Gly Leu His Asp Leu Arg Phe Lys Ile Thr Ile Ile Pro Gln Asp 
                 1365                1370                1375
Pro Val Leu Phe Ser Gly Ser Leu Arg Met Asn Leu Asp Pro Phe Ser 
             1380                1385                1390
Gln Tyr Ser Asp Glu Glu Val Trp Thr Ser Leu Glu Leu Ala His Leu 
         1395                1400                1405
Lys Asp Phe Val Ser Ala Leu Pro Asp Lys Leu Asp His Glu Cys Ala 
     1410                1415                1420
Glu Gly Gly Glu Asn Leu Ser Val Gly Gln Arg Gln Leu Val Cys Leu 
 1425                1430                1435                1440
Ala Arg Ala Leu Leu Arg Lys Thr Lys Ile Leu Val Leu Asp Glu Ala 
                 1445                1450                1455
Thr Ala Ala Val Asp Leu Glu Thr Asp Asp Leu Ile Gln Ser Thr Ile 
             1460                1465                1470
Arg Thr Gln Phe Glu Asp Cys Thr Val Leu Thr Ile Ala His Arg Leu 
         1475                1480                1485
Asn Thr Ile Met Asp Tyr Thr Arg Val Ile Val Leu Asp Lys Gly Glu 
     1490                1495                1500
Ile Gln Glu Tyr Gly Ala Pro Ser Asp Leu Leu Gln Gln Arg Gly Leu 
 1505                1510                1515                1520
Phe Tyr Ser Met Ala Lys Asp Ala Gly Leu Val 
                 1525                1530



<210> 10195
<211> 724
<212> PRT
<213> Rattus norvegicus
<308> P70531
<400> 10195

Met Ala Asp Glu Asp Leu Ile Phe Arg Leu Glu Gly Val Asp Gly Gly 
  1               5                  10                  15
Gly Ser Ser Gly Ala Gly Arg His Gly Asp Ser Asp Thr Asp Ser Asp 
             20                  25                  30
Asp Asp Glu Gly Tyr Phe Ile Cys Pro Ile Thr Asp Asp His Met Ser 
         35                  40                  45
Asn Gln Asn Val Asn Ser Lys Gly Gln Gly Tyr Tyr Asn Asn Leu Leu 
     50                  55                  60
Lys Thr Glu Cys Gly Ser Thr Gly Ser Pro Ala Ser Ser Phe His Phe 
 65                  70                  75                  80
Lys Glu Ala Trp Lys His Ala Ile Glu Lys Ala Lys His Met Pro Asp 
                 85                  90                  95
Pro Trp Ala Glu Phe His Leu Glu Asp Ile Ala Thr Glu His Ala Thr 
             100                105                110
Arg His Arg Tyr Asn Ala Val Thr Gly Glu Trp Leu Lys Asp Glu Val 
         115                120                125
Leu Ile Lys Met Ala Ser Gln Pro Phe Gly Arg Gly Ala Met Arg Glu 
     130                135                140
Cys Phe Arg Thr Lys Lys Leu Ser Asn Phe Leu His Ala Gln His Trp 
 145                150                155                160
Lys Gly Ala Ser Asn Tyr Val Ala Lys Arg Tyr Leu Glu Pro Val Asp 
                 165                170                175
Arg Ser Val Tyr Phe Glu Asp Val Gln Leu Gln Met Glu Ala Lys Leu 
             180                185                190
Trp Gly Glu Glu Tyr Asn Arg His Lys Pro Pro Lys Gln Val Asp Ile 
         195                200                205
Met Gln Met Cys Ile Ile Glu Leu Lys Asp Arg Gln Gly Gln Pro Leu 
     210                215                220
Phe His Leu Glu His Tyr Ile Glu Gly Lys Tyr Ile Lys Tyr Asn Ser 
 225                230                235                240
Asn Ser Gly Phe Val Arg Asp Asp Asn Ile Arg Leu Thr Pro Gln Ala 
                 245                250                255
Phe Ser His Phe Thr Phe Glu Arg Ser Gly His Gln Leu Ile Val Val 
             260                265                270
Asp Ile Gln Gly Val Gly Asp Leu Tyr Thr Asp Pro Gln Ile His Thr 
         275                280                285
Glu Lys Gly Thr Asp Phe Gly Asp Gly Asn Leu Gly Val Arg Gly Met 
     290                295                300
Ala Leu Phe Phe Tyr Ser His Ala Cys Asn Arg Ile Cys Gln Ser Met 
 305                310                315                320
Gly Leu Ala Pro Phe Asp Leu Ser Pro Arg Glu Gln Asp Ala Val Asn 
                 325                330                335
Gln Ser Thr Lys Leu Leu Gln Ser Ala Lys Thr Ile Leu Arg Gly Thr 
             340                345                350
Glu Glu Lys Cys Gly Ser Pro Arg Ile Arg Thr Leu Ser Gly Ser Arg 
         355                360                365
Pro Pro Leu Leu Leu Arg Leu Ser Glu Asn Ser Gly Asp Glu Asn Met 
     370                375                380
Ser Asp Val Thr Phe Asp Ser Leu Pro Ser Ser Pro Ser Ser Ala Thr 
 385                390                395                400
Pro His Ser Gln Lys Leu Asp His Leu His Trp Pro Val Phe Gly Asp 
                 405                410                415
Leu Asp Asn Met Gly Pro Arg Asp His Asp Arg Met Asp Asn His Arg 
             420                425                430
Asp Ser Glu Asn Ser Gly Asp Ser Gly Tyr Pro Ser Glu Lys Arg Ser 
         435                440                445
Asp Leu Asp Asp Pro Glu Pro Arg Glu His Gly His Ser Asn Gly Asn 
     450                455                460
Arg Arg Pro Glu Ser Asp Glu Asp Ser Leu Gly Ser Ser Gly Arg Val 
 465                470                475                480
Cys Val Glu Thr Trp Asn Leu Leu Asn Pro Ser Arg Leu His Leu Pro 
                 485                490                495
Arg Pro Ser Ala Val Ala Leu Glu Val Gln Arg Leu Asn Ala Leu Asp 
             500                505                510
Leu Gly Arg Lys Ile Gly Lys Ser Val Leu Gly Lys Val His Leu Ala 
         515                520                525
Met Val Arg Tyr His Glu Gly Gly Arg Phe Cys Glu Lys Asp Glu Glu 
     530                535                540
Trp Asp Gln Glu Ser Ala Ile Phe His Leu Glu His Ala Ala Asp Leu 
 545                550                555                560
Gly Glu Leu Glu Ala Ile Val Gly Leu Gly Leu Met Tyr Ser Gln Leu 
                 565                570                575
Pro His His Ile Leu Ala Asp Val Ser Leu Glu Glu Thr Glu Glu Asn 
             580                585                590
Lys Thr Lys Gly Phe Asp Tyr Leu Leu Lys Ala Ala Glu Ala Gly Asp 
         595                600                605
Arg Gln Ser Met Ile Leu Val Ala Arg Ala Phe Asp Thr Gly Leu Asn 
     610                615                620
Leu Ser Pro Asp Arg Cys Gln Asp Trp Ser Glu Ala Leu His Trp Tyr 
 625                630                635                640
Asn Thr Ala Leu Glu Thr Thr Asp Cys Asp Glu Gly Gly Glu Tyr Asp 
                 645                650                655
Gly Ile Gln Asp Glu Pro Gln Tyr Ala Leu Leu Ala Arg Glu Ala Glu 
             660                665                670
Met Leu Leu Thr Gly Gly Phe Gly Leu Asp Lys Asn Pro Gln Arg Ser 
         675                680                685
Gly Asp Leu Tyr Thr Gln Ala Ala Glu Ala Ala Met Glu Ala Met Lys 
     690                695                700
Gly Arg Leu Ala Asn Gln Tyr Tyr Glu Lys Ala Glu Glu Ala Trp Ala 
 705                710                715                720
Gln Met Glu Glu 
                 725



<210> 10197
<211> 725
<212> PRT
<213> Homo sapiens
<308> O00418
<400> 10197

Met Ala Asp Glu Asp Leu Ile Phe Arg Leu Glu Gly Val Asp Gly Gly 
  1               5                  10                  15
Gln Ser Pro Arg Ala Gly His Asp Gly Asp Ser Asp Gly Asp Ser Asp 
             20                  25                  30
Asp Glu Glu Gly Tyr Phe Ile Cys Pro Ile Thr Asp Asp Pro Ser Ser 
         35                  40                  45
Asn Gln Asn Val Asn Ser Lys Val Asn Lys Tyr Tyr Ser Asn Leu Thr 
     50                  55                  60
Lys Ser Glu Arg Tyr Ser Ser Ser Gly Ser Pro Ala Asn Ser Phe His 
 65                  70                  75                  80
Phe Lys Glu Ala Trp Lys His Ala Ile Gln Lys Ala Lys His Met Pro 
                 85                  90                  95
Asp Pro Trp Ala Glu Phe His Leu Glu Asp Ile Ala Thr Glu Arg Ala 
             100                105                110
Thr Arg His Arg Tyr Asn Ala Val Thr Gly Glu Trp Leu Asp Asp Glu 
         115                120                125
Val Leu Ile Lys Met Ala Ser Gln Pro Phe Gly Arg Gly Ala Met Arg 
     130                135                140
Glu Cys Phe Arg Thr Lys Lys Leu Ser Asn Phe Leu His Ala Gln Gln 
 145                150                155                160
Trp Lys Gly Ala Ser Asn Tyr Val Ala Lys Arg Tyr Ile Glu Pro Val 
                 165                170                175
Asp Arg Asp Val Tyr Phe Glu Asp Val Arg Leu Gln Met Glu Ala Lys 
             180                185                190
Leu Trp Gly Glu Glu Tyr Asn Arg His Lys Pro Pro Lys Gln Val Asp 
         195                200                205
Ile Met Gln Met Cys Ile Ile Glu Leu Lys Asp Arg Pro Gly Lys Pro 
     210                215                220
Leu Phe His Leu Glu His Tyr Ile Glu Gly Lys Tyr Ile Lys Tyr Asn 
 225                230                235                240
Ser Asn Ser Gly Phe Val Arg Asp Asp Asn Ile Arg Leu Thr Pro Gln 
                 245                250                255
Ala Phe Ser His Phe Thr Phe Glu Arg Ser Gly His Gln Leu Ile Val 
             260                265                270
Val Asp Ile Gln Gly Val Gly Asp Leu Tyr Thr Asp Pro Gln Ile His 
         275                280                285
Thr Glu Thr Gly Thr Asp Phe Gly Asp Gly Asn Leu Gly Val Arg Gly 
     290                295                300
Met Ala Leu Phe Phe Tyr Ser His Ala Cys Asn Arg Ile Cys Glu Ser 
 305                310                315                320
Met Gly Leu Ala Pro Phe Asp Leu Ser Pro Arg Glu Arg Asp Ala Val 
                 325                330                335
Asn Gln Asn Thr Lys Leu Leu Gln Ser Ala Lys Thr Ile Leu Arg Gly 
             340                345                350
Thr Glu Glu Lys Cys Gly Ser Pro Arg Val Arg Thr Leu Ser Gly Ser 
         355                360                365
Arg Pro Pro Leu Leu Arg Pro Leu Ser Glu Asn Ser Gly Asp Glu Asn 
     370                375                380
Met Ser Asp Val Thr Phe Asp Ser Leu Pro Ser Ser Pro Ser Ser Ala 
 385                390                395                400
Thr Pro His Ser Gln Lys Leu Asp His Leu His Trp Pro Val Phe Ser 
                 405                410                415
Asp Leu Asp Asn Met Ala Ser Arg Asp His Asp His Leu Asp Asn His 
             420                425                430
Arg Glu Ser Glu Asn Ser Gly Asp Ser Gly Tyr Pro Ser Glu Lys Arg 
         435                440                445
Gly Glu Leu Asp Asp Pro Glu Pro Arg Glu His Gly His Ser Tyr Ser 
     450                455                460
Asn Arg Lys Tyr Glu Ser Asp Glu Asp Ser Leu Gly Ser Ser Gly Arg 
 465                470                475                480
Val Cys Val Glu Lys Trp Asn Leu Leu Asn Ser Ser Arg Leu His Leu 
                 485                490                495
Pro Arg Ala Ser Ala Val Ala Leu Glu Val Gln Arg Leu Asn Ala Leu 
             500                505                510
Asp Leu Glu Lys Lys Ile Gly Lys Ser Ile Leu Gly Lys Val His Leu 
         515                520                525
Ala Met Val Arg Tyr His Glu Gly Gly Arg Phe Cys Glu Lys Gly Glu 
     530                535                540
Glu Trp Asp Gln Glu Ser Ala Val Phe His Leu Glu His Ala Ala Asn 
 545                550                555                560
Leu Gly Glu Leu Glu Ala Ile Val Gly Leu Gly Leu Met Tyr Ser Gln 
                 565                570                575
Leu Pro His His Ile Leu Ala Asp Val Ser Leu Lys Glu Thr Glu Glu 
             580                585                590
Asn Lys Thr Lys Gly Phe Asp Tyr Leu Leu Lys Ala Ala Glu Ala Gly 
         595                600                605
Asp Arg Gln Ser Met Ile Leu Val Ala Arg Ala Phe Asp Ser Gly Gln 
     610                615                620
Asn Leu Ser Pro Asp Arg Cys Gln Asp Trp Leu Glu Ala Leu His Trp 
 625                630                635                640
Tyr Asn Thr Ala Leu Glu Met Thr Asp Cys Asp Glu Gly Gly Glu Tyr 
                 645                650                655
Asp Gly Met Gln Asp Glu Pro Arg Tyr Met Met Leu Ala Arg Glu Ala 
             660                665                670
Glu Met Leu Phe Thr Gly Gly Tyr Gly Leu Glu Lys Asp Pro Gln Arg 
         675                680                685
Ser Gly Asp Leu Tyr Thr Gln Ala Ala Glu Ala Ala Met Glu Ala Met 
     690                695                700
Lys Gly Arg Leu Ala Asn Gln Tyr Tyr Gln Lys Ala Glu Glu Ala Trp 
 705                710                715                720
Ala Gln Met Glu Glu 
                 725



<210> 10198
<211> 1758
<212> DNA
<213> Rattus norvegicus
<308> X96437
<400> 10198

gcccagatg  aggaataagaatagcgt  tcgggagtg  ccctgggta  tcgctgcat  tcgttttgt  tgtgtgctc  60
gtcgaaacg  ctgtgatgt  tgtatggtt  tcacgtgaa  ggaggcagg  agagttggg  120
ctgtgggtt  tagtgtgtt  ttaatcttt  tggaagttt  tgcagtgac  tcccctctg  180
gattgtttc  tatgcatac  ttcaagtat  tgtgaatgt  ttttctgtg  tcccttgat  240
ttactgggc  tctctaagg  gggtggctg  accatctgc  acgtgtctg  gagcccctc  300
ctagctacc  catgtcccg  catgtgctt  ctcccaata  ttgcaccca  tcgcattca  360
aactcccag  caaaaagaa  aaatcaaaa  aacaaaaaa  acgtgcact  gggcaccta  420
aaaatgggc  gccaaggct  cgcctacat  ttgcttcct  cttggaatt  ccagccctg  480
gcagccaac  gctccctag  tgcgaaggg  ggagtttcc  ggctctata  gtagtggtg  540
cttaccggg  atccgcact  ctccgtacc  tctgtacag  gcgcgaatt  tgtgccatt  600
gcgtaacca  ctccacacc  tgactggcc  gagggctcc  gcgccagtt  cctccaccg  660
cccggaact  cggcggggc  ccggtcccg  aattttcac  ttcgacccc  tcccggagc  720
ggcggtagc  tccgccgtg  gtccgaaca  ttctcgcgg  cacggaaaa  gcagccgac  780
ggtgctcta  cctcgagtg  tgagtatcg  ccgagtggg  agcaagagg  cgagtcgcc  840
cggaacctt  gggaacaac  agatgcggg  actttcgtc  gacgtttcc  tcttttctc  900
gctcaggtc  ggcgccagc  accaaccga  gaacccaac  ttgccaaga  gatcctctt  960
ctcctgctc  ccatcatct  ctgccagat  ttgatggct  aagaaggtg  gtcgcaggc  1020
ctggctccg  aggatgcta  cagcgccat  tcacctgag  ccatctctg  gcccattac  1080
gcgcctcct  tcctcgagc  tttgaacct  acctcggag  cctcggact  tgctctgga  1140
ctcaaagct  ttctccagc  acacccggc  gcattctaa  cgcgatggg  cacagtccg  1200
aaaaaaaaa  ccaaagagc  ccaggggta  ctggtcggc  agaacgtat  ccaaactgg  1260
acttataag  caacgctaa  tcagaacac  accgccaag  tgccggttc  tggggcgag  1320
ccgaggcac  gtgggtcct  gctaggctc  ctggtgacg  acggaggtc  tctccgtgt  1380
taattaata  ttatgtatt  atgtatatc  tcctaggtg  aggaggggt  tatgtaata  1440
ttattctaa  ttatgcagg  gtgcgagat  tgccccctt  ctgtgacac  gatatttat  1500
acgatttat  gggtccgtg  gacagagtt  tgggaggat  agtttagtc  tggtcgggg  1560
gcataggtt  aggggtaac  ctccatttt  cagcacttc  actctgttg  aagactttg  1620
cagaccctt  ggaatacgg  ctgtgtgcc  ttgatgtct  cctgactgg  agtcttggg  1680
ccatggatt  tcagagggc  gctgtctgg  gtcgcctag  atgttctgt  aacacgaat  1740
aacttgatt  gcctgtcg  1758



<210> 10199
<211> 1864
<212> DNA
<213> Homo sapiens
<308> X96438
<400> 10199

ctactagaa  aaggacgga  ggagcgagg  agatcacga  gtcaggaaa  cgagaccac  60
ctggccaaa  gggtgaaac  ccgtctcta  taaaaatac  aaaattagc  gggcgtggt  120
gcgcgtgcc  gtattccca  ctactcagg  agctgaggc  ggaaaatcg  ttgaaccag  180
gagtcaggg  ttgcagtga  ccgagatcg  gcctctgga  tccagcctg  cgaccgaac  240
agactgctc  atctccaaa  aaaaaaaaa  aggcctgtg  gggatcctg  ggctaaagt  300
agcccctct  caggtgcca  atgcctcga  atgtgcctg  agcccggga  ctcacccac  360
cccactcac  actcacaca  tcacaacgt  cagttgggc  cctaggatt  tgcatgttc  420
agtctccac  cactccctt  gttaatcgt  ggaatttcc  gcccgctgc  gccaaccgc  480
ccccagctg  gggaggagg  gttagaagg  cccgcccaa  tttcaggag  acataaatt  540
cctctgccg  cagccgacc  tcacttggc  ttacactcc  ctcggctca  catgtgtca  600
tctcgcagc  gccacccga  catgaccat  ctgcaggcc  cgaccccgg  cccctccac  660
atcccggga  cccggcggg  ctccggtcc  gagatcttc  ccttcgacc  tctcccgga  720
cccgcagcg  cccctgccg  gcgccccag  gcctctcgc  ggcaccgaa  gcgcagccg  780
agggttctc  accctcgag  ggtgagtat  gccgaagtg  gcattcgcg  ggtgcgctg  840
cctggagtc  ctggggaac  acccgactc  agaggcctc  acctgacct  tctcctgtt  900
tgtctcccc  taggtccgg  gccagctgc  agtcgagga  ccgaaccca  ccaaaaggc  960
tctctttct  ctgctcacc  tcgtcttct  ccagatcct  atggctgaa  agggtgtgc  1020
ggcgcccct  cctccagag  acgccccta  cgccgcatc  ctggcgccc  cccctgtgt  1080
ccccgtcct  gagcccttt  atctgactt  ggagccctc  gactacgct  tggacctca  1140
cactttcct  cagcaacac  cggccgcct  ctaactgga  tccccgcac  ccccaaaaa  1200
aatccgaaa  accacaaag  aacaccagg  gtacctggt  gcgcgagag  gtatcccca  1260
ctgggactt  cgaggcaac  tgaactcag  acactacag  ggagacgcc  cccggtgct  1320
gagcgggac  gaggcgcac  gagaccgag  cgcatagag  ccgagcaca  cccagctgg  1380
ctaggcccg  tgggaagga  agcgtcgtt  atttatttc  tattgctcc  aattaatat  1440
tatatgtat  tatgtacgt  ctcctaggt  atggagatg  gtacgtaat  tttatttta  1500
cttatgcaa  ggtgtgaga  gttccccct  ctgtaaatg  aggtctctt  gtatttatt  1560
agctttgtg  gtctggtgg  agcaggaca  ctggaactg  ggcaaagta  gagaagaaa  1620
ggggaggac  cgggtgggg  aggacgtcc  ggctgggat  aagtctggt  gtgggtcgt  1680
agtttagga  gtgactgca  cctccagca  ctcaactcc  tctgtctac  gtgtgagac  1740
tcggcggac  attaggaat  agatccgtg  gatccttcc  tcttcttga  gtcgccttt  1800
gggtggctg  gaggtagag  gttgggggt  ggtgggctg  cacggagcg  ctgtcgaga  1860
cgcc  1864



<210> 10200
<211> 156
<212> PRT
<213> Homo sapiens
<308> CAA65304
<400> 10200

Met Cys His Ser Arg Ser Cys His Pro Thr Met Thr Ile Leu Gln Ala 
  1               5                  10                  15
Pro Thr Pro Ala Pro Ser Thr Ile Pro Gly Pro Arg Arg Gly Ser Gly 
             20                  25                  30
Pro Glu Ile Phe Thr Phe Asp Pro Leu Pro Glu Pro Ala Ala Ala Pro 
         35                  40                  45
Ala Gly Arg Pro Ser Ala Ser Arg Gly His Arg Lys Arg Ser Arg Arg 
     50                  55                  60
Val Leu Tyr Pro Arg Val Val Arg Arg Gln Leu Pro Val Glu Glu Pro 
 65                  70                  75                  80
Asn Pro Ala Lys Arg Leu Leu Phe Leu Leu Leu Thr Ile Val Phe Cys 
                 85                  90                  95
Gln Ile Leu Met Ala Glu Glu Gly Val Pro Ala Pro Leu Pro Pro Glu 
             100                105                110
Asp Ala Pro Asn Ala Ala Ser Leu Ala Pro Thr Pro Val Ser Pro Val 
         115                120                125
Leu Glu Pro Phe Asn Leu Thr Ser Glu Pro Ser Asp Tyr Ala Leu Asp 
     130                135                140
Leu Ser Thr Phe Leu Gln Gln His Pro Ala Ala Phe 
 145                150                155



<210> 10201
<211> 1758
<212> DNA
<213> Rattus norvegicus
<308> X96437
<400> 10201

gaatagcgt  tcgggagtg  ccctgggta  tcgctgcat  tcgttttgt  tgtgtgctc  60
gtcgaaacg  ctgtgatgt  tgtatggtt  tcacgtgaa  ggaggcagg  agagttggg  120
ctgtgggtt  tagtgtgtt  ttaatcttt  tggaagttt  tgcagtgac  tcccctctg  180
gattgtttc  tatgcatac  ttcaagtat  tgtgaatgt  ttttctgtg  tcccttgat  240
ttactgggc  tctctaagg  gggtggctg  accatctgc  acgtgtctg  gagcccctc  300
ctagctacc  catgtcccg  catgtgctt  ctcccaata  ttgcaccca  tcgcattca  360
aactcccag  caaaaagaa  aaatcaaaa  aacaaaaaa  acgtgcact  gggcaccta  420
aaaatgggc  gccaaggct  cgcctacat  ttgcttcct  cttggaatt  ccagccctg  480
gcagccaac  gctccctag  tgcgaaggg  ggagtttcc  ggctctata  gtagtggtg  540
cttaccggg  atccgcact  ctccgtacc  tctgtacag  gcgcgaatt  tgtgccatt  600
gcgtaacca  ctccacacc  tgactggcc  gagggctcc  gcgccagtt  cctccaccg  660
cccggaact  cggcggggc  ccggtcccg  aattttcac  ttcgacccc  tcccggagc  720
ggcggtagc  tccgccgtg  gtccgaaca  ttctcgcgg  cacggaaaa  gcagccgac  780
ggtgctcta  cctcgagtg  tgagtatcg  ccgagtggg  agcaagagg  cgagtcgcc  840
cggaacctt  gggaacaac  agatgcggg  actttcgtc  gacgtttcc  tcttttctc  900
gctcaggtc  ggcgccagc  accaaccga  gaacccaac  ttgccaaga  gatcctctt  960
ctcctgctc  ccatcatct  ctgccagat  ttgatggct  aagaaggtg  gtcgcaggc  1020
ctggctccg  aggatgcta  cagcgccat  tcacctgag  ccatctctg  gcccattac  1080
gcgcctcct  tcctcgagc  tttgaacct  acctcggag  cctcggact  tgctctgga  1140
ctcaaagct  ttctccagc  acacccggc  gcattctaa  cgcgatggg  cacagtccg  1200
aaaaaaaaa  ccaaagagc  ccaggggta  ctggtcggc  agaacgtat  ccaaactgg  1260
acttataag  caacgctaa  tcagaacac  accgccaag  tgccggttc  tggggcgag  1320
ccgaggcac  gtgggtcct  gctaggctc  ctggtgacg  acggaggtc  tctccgtgt  1380
taattaata  ttatgtatt  atgtatatc  tcctaggtg  aggaggggt  tatgtaata  1440
ttattctaa  ttatgcagg  gtgcgagat  tgccccctt  ctgtgacac  gatatttat  1500
acgatttat  gggtccgtg  gacagagtt  tgggaggat  agtttagtc  tggtcgggg  1560
gcataggtt  aggggtaac  ctccatttt  cagcacttc  actctgttg  aagactttg  1620
cagaccctt  ggaatacgg  ctgtgtgcc  ttgatgtct  cctgactgg  agtcttggg  1680
ccatggatt  tcagagggc  gctgtctgg  gtcgcctag  atgttctgt  aacacgaat  1740
aacttgatt  gcctgtcg  1758



<210> 10202
<211> 1864
<212> DNA
<213> Homo sapiens
<308> X96438
<400> 10202

ctactagaa  aaggacgga  ggagcgagg  agatcacga  gtcaggaaa  cgagaccac  60
ctggccaaa  gggtgaaac  ccgtctcta  taaaaatac  aaaattagc  gggcgtggt  120
gcgcgtgcc  gtattccca  ctactcagg  agctgaggc  ggaaaatcg  ttgaaccag  180
gagtcaggg  ttgcagtga  ccgagatcg  gcctctgga  tccagcctg  cgaccgaac  240
agactgctc  atctccaaa  aaaaaaaaa  aggcctgtg  gggatcctg  ggctaaagt  300
agcccctct  caggtgcca  atgcctcga  atgtgcctg  agcccggga  ctcacccac  360
cccactcac  actcacaca  tcacaacgt  cagttgggc  cctaggatt  tgcatgttc  420
agtctccac  cactccctt  gttaatcgt  ggaatttcc  gcccgctgc  gccaaccgc  480
ccccagctg  gggaggagg  gttagaagg  cccgcccaa  tttcaggag  acataaatt  540
cctctgccg  cagccgacc  tcacttggc  ttacactcc  ctcggctca  catgtgtca  600
tctcgcagc  gccacccga  catgaccat  ctgcaggcc  cgaccccgg  cccctccac  660
atcccggga  cccggcggg  ctccggtcc  gagatcttc  ccttcgacc  tctcccgga  720
cccgcagcg  cccctgccg  gcgccccag  gcctctcgc  ggcaccgaa  gcgcagccg  780
agggttctc  accctcgag  ggtgagtat  gccgaagtg  gcattcgcg  ggtgcgctg  840
cctggagtc  ctggggaac  acccgactc  agaggcctc  acctgacct  tctcctgtt  900
tgtctcccc  taggtccgg  gccagctgc  agtcgagga  ccgaaccca  ccaaaaggc  960
tctctttct  ctgctcacc  tcgtcttct  ccagatcct  atggctgaa  agggtgtgc  1020
ggcgcccct  cctccagag  acgccccta  cgccgcatc  ctggcgccc  cccctgtgt  1080
ccccgtcct  gagcccttt  atctgactt  ggagccctc  gactacgct  tggacctca  1140
cactttcct  cagcaacac  cggccgcct  ctaactgga  tccccgcac  ccccaaaaa  1200
aatccgaaa  accacaaag  aacaccagg  gtacctggt  gcgcgagag  gtatcccca  1260
ctgggactt  cgaggcaac  tgaactcag  acactacag  ggagacgcc  cccggtgct  1320
gagcgggac  gaggcgcac  gagaccgag  cgcatagag  ccgagcaca  cccagctgg  1380
ctaggcccg  tgggaagga  agcgtcgtt  atttatttc  tattgctcc  aattaatat  1440
tatatgtat  tatgtacgt  ctcctaggt  atggagatg  gtacgtaat  tttatttta  1500
cttatgcaa  ggtgtgaga  gttccccct  ctgtaaatg  aggtctctt  gtatttatt  1560
agctttgtg  gtctggtgg  agcaggaca  ctggaactg  ggcaaagta  gagaagaaa  1620
ggggaggac  cgggtgggg  aggacgtcc  ggctgggat  aagtctggt  gtgggtcgt  1680
agtttagga  gtgactgca  cctccagca  ctcaactcc  tctgtctac  gtgtgagac  1740
tcggcggac  attaggaat  agatccgtg  gatccttcc  tcttcttga  gtcgccttt  1800
gggtggctg  gaggtagag  gttgggggt  ggtgggctg  cacggagcg  ctgtcgaga  1860
cgcc  1864



<210> 10203
<211> 156
<212> PRT
<213> Homo sapiens
<308> CAA65304
<400> 10203

Met Cys His Ser Arg Ser Cys His Pro Thr Met Thr Ile Leu Gln Ala 
  1               5                  10                  15
Pro Thr Pro Ala Pro Ser Thr Ile Pro Gly Pro Arg Arg Gly Ser Gly 
             20                  25                  30
Pro Glu Ile Phe Thr Phe Asp Pro Leu Pro Glu Pro Ala Ala Ala Pro 
         35                  40                  45
Ala Gly Arg Pro Ser Ala Ser Arg Gly His Arg Lys Arg Ser Arg Arg 
     50                  55                  60
Val Leu Tyr Pro Arg Val Val Arg Arg Gln Leu Pro Val Glu Glu Pro 
 65                  70                  75                  80
Asn Pro Ala Lys Arg Leu Leu Phe Leu Leu Leu Thr Ile Val Phe Cys 
                 85                  90                  95
Gln Ile Leu Met Ala Glu Glu Gly Val Pro Ala Pro Leu Pro Pro Glu 
             100                105                110
Asp Ala Pro Asn Ala Ala Ser Leu Ala Pro Thr Pro Val Ser Pro Val 
         115                120                125
Leu Glu Pro Phe Asn Leu Thr Ser Glu Pro Ser Asp Tyr Ala Leu Asp 
     130                135                140
Leu Ser Thr Phe Leu Gln Gln His Pro Ala Ala Phe 
 145                150                155



<210> 10204
<211> 1758
<212> DNA
<213> Rattus norvegicus
<308> X96437
<400> 10204

gaatagcgt  tcgggagtg  ccctgggta  tcgctgcat  tcgttttgt  tgtgtgctc  60
gtcgaaacg  ctgtgatgt  tgtatggtt  tcacgtgaa  ggaggcagg  agagttggg  120
ctgtgggtt  tagtgtgtt  ttaatcttt  tggaagttt  tgcagtgac  tcccctctg  180
gattgtttc  tatgcatac  ttcaagtat  tgtgaatgt  ttttctgtg  tcccttgat  240
ttactgggc  tctctaagg  gggtggctg  accatctgc  acgtgtctg  gagcccctc  300
ctagctacc  catgtcccg  catgtgctt  ctcccaata  ttgcaccca  tcgcattca  360
aactcccag  caaaaagaa  aaatcaaaa  aacaaaaaa  acgtgcact  gggcaccta  420
aaaatgggc  gccaaggct  cgcctacat  ttgcttcct  cttggaatt  ccagccctg  480
gcagccaac  gctccctag  tgcgaaggg  ggagtttcc  ggctctata  gtagtggtg  540
cttaccggg  atccgcact  ctccgtacc  tctgtacag  gcgcgaatt  tgtgccatt  600
gcgtaacca  ctccacacc  tgactggcc  gagggctcc  gcgccagtt  cctccaccg  660
cccggaact  cggcggggc  ccggtcccg  aattttcac  ttcgacccc  tcccggagc  720
ggcggtagc  tccgccgtg  gtccgaaca  ttctcgcgg  cacggaaaa  gcagccgac  780
ggtgctcta  cctcgagtg  tgagtatcg  ccgagtggg  agcaagagg  cgagtcgcc  840
cggaacctt  gggaacaac  agatgcggg  actttcgtc  gacgtttcc  tcttttctc  900
gctcaggtc  ggcgccagc  accaaccga  gaacccaac  ttgccaaga  gatcctctt  960
ctcctgctc  ccatcatct  ctgccagat  ttgatggct  aagaaggtg  gtcgcaggc  1020
ctggctccg  aggatgcta  cagcgccat  tcacctgag  ccatctctg  gcccattac  1080
gcgcctcct  tcctcgagc  tttgaacct  acctcggag  cctcggact  tgctctgga  1140
ctcaaagct  ttctccagc  acacccggc  gcattctaa  cgcgatggg  cacagtccg  1200
aaaaaaaaa  ccaaagagc  ccaggggta  ctggtcggc  agaacgtat  ccaaactgg  1260
acttataag  caacgctaa  tcagaacac  accgccaag  tgccggttc  tggggcgag  1320
ccgaggcac  gtgggtcct  gctaggctc  ctggtgacg  acggaggtc  tctccgtgt  1380
taattaata  ttatgtatt  atgtatatc  tcctaggtg  aggaggggt  tatgtaata  1440
ttattctaa  ttatgcagg  gtgcgagat  tgccccctt  ctgtgacac  gatatttat  1500
acgatttat  gggtccgtg  gacagagtt  tgggaggat  agtttagtc  tggtcgggg  1560
gcataggtt  aggggtaac  ctccatttt  cagcacttc  actctgttg  aagactttg  1620
cagaccctt  ggaatacgg  ctgtgtgcc  ttgatgtct  cctgactgg  agtcttggg  1680
ccatggatt  tcagagggc  gctgtctgg  gtcgcctag  atgttctgt  aacacgaat  1740
aacttgatt  gcctgtcg  1758



<210> 10205
<211> 1864
<212> DNA
<213> Homo sapiens
<308> X96438
<400> 10205

ctactagaa  aaggacgga  ggagcgagg  agatcacga  gtcaggaaa  cgagaccac  60
ctggccaaa  gggtgaaac  ccgtctcta  taaaaatac  aaaattagc  gggcgtggt  120
gcgcgtgcc  gtattccca  ctactcagg  agctgaggc  ggaaaatcg  ttgaaccag  180
gagtcaggg  ttgcagtga  ccgagatcg  gcctctgga  tccagcctg  cgaccgaac  240
agactgctc  atctccaaa  aaaaaaaaa  aggcctgtg  gggatcctg  ggctaaagt  300
agcccctct  caggtgcca  atgcctcga  atgtgcctg  agcccggga  ctcacccac  360
cccactcac  actcacaca  tcacaacgt  cagttgggc  cctaggatt  tgcatgttc  420
agtctccac  cactccctt  gttaatcgt  ggaatttcc  gcccgctgc  gccaaccgc  480
ccccagctg  gggaggagg  gttagaagg  cccgcccaa  tttcaggag  acataaatt  540
cctctgccg  cagccgacc  tcacttggc  ttacactcc  ctcggctca  catgtgtca  600
tctcgcagc  gccacccga  catgaccat  ctgcaggcc  cgaccccgg  cccctccac  660
atcccggga  cccggcggg  ctccggtcc  gagatcttc  ccttcgacc  tctcccgga  720
cccgcagcg  cccctgccg  gcgccccag  gcctctcgc  ggcaccgaa  gcgcagccg  780
agggttctc  accctcgag  ggtgagtat  gccgaagtg  gcattcgcg  ggtgcgctg  840
cctggagtc  ctggggaac  acccgactc  agaggcctc  acctgacct  tctcctgtt  900
tgtctcccc  taggtccgg  gccagctgc  agtcgagga  ccgaaccca  ccaaaaggc  960
tctctttct  ctgctcacc  tcgtcttct  ccagatcct  atggctgaa  agggtgtgc  1020
ggcgcccct  cctccagag  acgccccta  cgccgcatc  ctggcgccc  cccctgtgt  1080
ccccgtcct  gagcccttt  atctgactt  ggagccctc  gactacgct  tggacctca  1140
cactttcct  cagcaacac  cggccgcct  ctaactgga  tccccgcac  ccccaaaaa  1200
aatccgaaa  accacaaag  aacaccagg  gtacctggt  gcgcgagag  gtatcccca  1260
ctgggactt  cgaggcaac  tgaactcag  acactacag  ggagacgcc  cccggtgct  1320
gagcgggac  gaggcgcac  gagaccgag  cgcatagag  ccgagcaca  cccagctgg  1380
ctaggcccg  tgggaagga  agcgtcgtt  atttatttc  tattgctcc  aattaatat  1440
tatatgtat  tatgtacgt  ctcctaggt  atggagatg  gtacgtaat  tttatttta  1500
cttatgcaa  ggtgtgaga  gttccccct  ctgtaaatg  aggtctctt  gtatttatt  1560
agctttgtg  gtctggtgg  agcaggaca  ctggaactg  ggcaaagta  gagaagaaa  1620
ggggaggac  cgggtgggg  aggacgtcc  ggctgggat  aagtctggt  gtgggtcgt  1680
agtttagga  gtgactgca  cctccagca  ctcaactcc  tctgtctac  gtgtgagac  1740
tcggcggac  attaggaat  agatccgtg  gatccttcc  tcttcttga  gtcgccttt  1800
gggtggctg  gaggtagag  gttgggggt  ggtgggctg  cacggagcg  ctgtcgaga  1860
cgcc  1864



<210> 10206
<211> 156
<212> PRT
<213> Homo sapiens
<308> CAA65304
<400> 10206

Met Cys His Ser Arg Ser Cys His Pro Thr Met Thr Ile Leu Gln Ala 
  1               5                  10                  15
Pro Thr Pro Ala Pro Ser Thr Ile Pro Gly Pro Arg Arg Gly Ser Gly 
             20                  25                  30
Pro Glu Ile Phe Thr Phe Asp Pro Leu Pro Glu Pro Ala Ala Ala Pro 
         35                  40                  45
Ala Gly Arg Pro Ser Ala Ser Arg Gly His Arg Lys Arg Ser Arg Arg 
     50                  55                  60
Val Leu Tyr Pro Arg Val Val Arg Arg Gln Leu Pro Val Glu Glu Pro 
 65                  70                  75                  80
Asn Pro Ala Lys Arg Leu Leu Phe Leu Leu Leu Thr Ile Val Phe Cys 
                 85                  90                  95
Gln Ile Leu Met Ala Glu Glu Gly Val Pro Ala Pro Leu Pro Pro Glu 
             100                105                110
Asp Ala Pro Asn Ala Ala Ser Leu Ala Pro Thr Pro Val Ser Pro Val 
         115                120                125
Leu Glu Pro Phe Asn Leu Thr Ser Glu Pro Ser Asp Tyr Ala Leu Asp 
     130                135                140
Leu Ser Thr Phe Leu Gln Gln His Pro Ala Ala Phe 
 145                150                155



<210> 10207
<211> 1758
<212> DNA
<213> Rattus norvegicus
<308> X96437
<400> 10207

gaatagcgt  tcgggagtg  ccctgggta  tcgctgcat  tcgttttgt  tgtgtgctc  60
gtcgaaacg  ctgtgatgt  tgtatggtt  tcacgtgaa  ggaggcagg  agagttggg  120
ctgtgggtt  tagtgtgtt  ttaatcttt  tggaagttt  tgcagtgac  tcccctctg  180
gattgtttc  tatgcatac  ttcaagtat  tgtgaatgt  ttttctgtg  tcccttgat  240
ttactgggc  tctctaagg  gggtggctg  accatctgc  acgtgtctg  gagcccctc  300
ctagctacc  catgtcccg  catgtgctt  ctcccaata  ttgcaccca  tcgcattca  360
aactcccag  caaaaagaa  aaatcaaaa  aacaaaaaa  acgtgcact  gggcaccta  420
aaaatgggc  gccaaggct  cgcctacat  ttgcttcct  cttggaatt  ccagccctg  480
gcagccaac  gctccctag  tgcgaaggg  ggagtttcc  ggctctata  gtagtggtg  540
cttaccggg  atccgcact  ctccgtacc  tctgtacag  gcgcgaatt  tgtgccatt  600
gcgtaacca  ctccacacc  tgactggcc  gagggctcc  gcgccagtt  cctccaccg  660
cccggaact  cggcggggc  ccggtcccg  aattttcac  ttcgacccc  tcccggagc  720
ggcggtagc  tccgccgtg  gtccgaaca  ttctcgcgg  cacggaaaa  gcagccgac  780
ggtgctcta  cctcgagtg  tgagtatcg  ccgagtggg  agcaagagg  cgagtcgcc  840
cggaacctt  gggaacaac  agatgcggg  actttcgtc  gacgtttcc  tcttttctc  900
gctcaggtc  ggcgccagc  accaaccga  gaacccaac  ttgccaaga  gatcctctt  960
ctcctgctc  ccatcatct  ctgccagat  ttgatggct  aagaaggtg  gtcgcaggc  1020
ctggctccg  aggatgcta  cagcgccat  tcacctgag  ccatctctg  gcccattac  1080
gcgcctcct  tcctcgagc  tttgaacct  acctcggag  cctcggact  tgctctgga  1140
ctcaaagct  ttctccagc  acacccggc  gcattctaa  cgcgatggg  cacagtccg  1200
aaaaaaaaa  ccaaagagc  ccaggggta  ctggtcggc  agaacgtat  ccaaactgg  1260
acttataag  caacgctaa  tcagaacac  accgccaag  tgccggttc  tggggcgag  1320
ccgaggcac  gtgggtcct  gctaggctc  ctggtgacg  acggaggtc  tctccgtgt  1380
taattaata  ttatgtatt  atgtatatc  tcctaggtg  aggaggggt  tatgtaata  1440
ttattctaa  ttatgcagg  gtgcgagat  tgccccctt  ctgtgacac  gatatttat  1500
acgatttat  gggtccgtg  gacagagtt  tgggaggat  agtttagtc  tggtcgggg  1560
gcataggtt  aggggtaac  ctccatttt  cagcacttc  actctgttg  aagactttg  1620
cagaccctt  ggaatacgg  ctgtgtgcc  ttgatgtct  cctgactgg  agtcttggg  1680
ccatggatt  tcagagggc  gctgtctgg  gtcgcctag  atgttctgt  aacacgaat  1740
aacttgatt  gcctgtcg  1758



<210> 10208
<211> 1864
<212> DNA
<213> Homo sapiens
<308> X96438
<400> 10208

ctactagaa  aaggacgga  ggagcgagg  agatcacga  gtcaggaaa  cgagaccac  60
ctggccaaa  gggtgaaac  ccgtctcta  taaaaatac  aaaattagc  gggcgtggt  120
gcgcgtgcc  gtattccca  ctactcagg  agctgaggc  ggaaaatcg  ttgaaccag  180
gagtcaggg  ttgcagtga  ccgagatcg  gcctctgga  tccagcctg  cgaccgaac  240
agactgctc  atctccaaa  aaaaaaaaa  aggcctgtg  gggatcctg  ggctaaagt  300
agcccctct  caggtgcca  atgcctcga  atgtgcctg  agcccggga  ctcacccac  360
cccactcac  actcacaca  tcacaacgt  cagttgggc  cctaggatt  tgcatgttc  420
agtctccac  cactccctt  gttaatcgt  ggaatttcc  gcccgctgc  gccaaccgc  480
ccccagctg  gggaggagg  gttagaagg  cccgcccaa  tttcaggag  acataaatt  540
cctctgccg  cagccgacc  tcacttggc  ttacactcc  ctcggctca  catgtgtca  600
tctcgcagc  gccacccga  catgaccat  ctgcaggcc  cgaccccgg  cccctccac  660
atcccggga  cccggcggg  ctccggtcc  gagatcttc  ccttcgacc  tctcccgga  720
cccgcagcg  cccctgccg  gcgccccag  gcctctcgc  ggcaccgaa  gcgcagccg  780
agggttctc  accctcgag  ggtgagtat  gccgaagtg  gcattcgcg  ggtgcgctg  840
cctggagtc  ctggggaac  acccgactc  agaggcctc  acctgacct  tctcctgtt  900
tgtctcccc  taggtccgg  gccagctgc  agtcgagga  ccgaaccca  ccaaaaggc  960
tctctttct  ctgctcacc  tcgtcttct  ccagatcct  atggctgaa  agggtgtgc  1020
ggcgcccct  cctccagag  acgccccta  cgccgcatc  ctggcgccc  cccctgtgt  1080
ccccgtcct  gagcccttt  atctgactt  ggagccctc  gactacgct  tggacctca  1140
cactttcct  cagcaacac  cggccgcct  ctaactgga  tccccgcac  ccccaaaaa  1200
aatccgaaa  accacaaag  aacaccagg  gtacctggt  gcgcgagag  gtatcccca  1260
ctgggactt  cgaggcaac  tgaactcag  acactacag  ggagacgcc  cccggtgct  1320
gagcgggac  gaggcgcac  gagaccgag  cgcatagag  ccgagcaca  cccagctgg  1380
ctaggcccg  tgggaagga  agcgtcgtt  atttatttc  tattgctcc  aattaatat  1440
tatatgtat  tatgtacgt  ctcctaggt  atggagatg  gtacgtaat  tttatttta  1500
cttatgcaa  ggtgtgaga  gttccccct  ctgtaaatg  aggtctctt  gtatttatt  1560
agctttgtg  gtctggtgg  agcaggaca  ctggaactg  ggcaaagta  gagaagaaa  1620
ggggaggac  cgggtgggg  aggacgtcc  ggctgggat  aagtctggt  gtgggtcgt  1680
agtttagga  gtgactgca  cctccagca  ctcaactcc  tctgtctac  gtgtgagac  1740
tcggcggac  attaggaat  agatccgtg  gatccttcc  tcttcttga  gtcgccttt  1800
gggtggctg  gaggtagag  gttgggggt  ggtgggctg  cacggagcg  ctgtcgaga  1860
cgcc  1864



<210> 10209
<211> 156
<212> PRT
<213> Homo sapiens
<308> CAA65304
<400> 10209

Met Cys His Ser Arg Ser Cys His Pro Thr Met Thr Ile Leu Gln Ala 
  1               5                  10                  15
Pro Thr Pro Ala Pro Ser Thr Ile Pro Gly Pro Arg Arg Gly Ser Gly 
             20                  25                  30
Pro Glu Ile Phe Thr Phe Asp Pro Leu Pro Glu Pro Ala Ala Ala Pro 
         35                  40                  45
Ala Gly Arg Pro Ser Ala Ser Arg Gly His Arg Lys Arg Ser Arg Arg 
     50                  55                  60
Val Leu Tyr Pro Arg Val Val Arg Arg Gln Leu Pro Val Glu Glu Pro 
 65                  70                  75                  80
Asn Pro Ala Lys Arg Leu Leu Phe Leu Leu Leu Thr Ile Val Phe Cys 
                 85                  90                  95
Gln Ile Leu Met Ala Glu Glu Gly Val Pro Ala Pro Leu Pro Pro Glu 
             100                105                110
Asp Ala Pro Asn Ala Ala Ser Leu Ala Pro Thr Pro Val Ser Pro Val 
         115                120                125
Leu Glu Pro Phe Asn Leu Thr Ser Glu Pro Ser Asp Tyr Ala Leu Asp 
     130                135                140
Leu Ser Thr Phe Leu Gln Gln His Pro Ala Ala Phe 
 145                150                155



<210> 10210
<211> 557
<212> DNA
<213> Rattus norvegicus
<308> X97374
<400> 10210

gcaggaccc  ggccactga  tccctctac  aactcttcc  tcccaggtg  acctcagac  60
tgggaatca  ctcagggag  aatggtgct  ggccctttg  gttgtggtc  ccacagctg  120
ctaaccctc  ccccagacc  tactgactg  catgtgccc  ttatgtgtt  cagcctctt  180
cttcccacg  ctgcaccat  aaaatcctg  tttgtgatg  cctgctgct  agcctgctc  240
ccagcgtgt  cagcagctg  cccgaggac  gcctcacct  ccaggagag  ctccacccg  300
ctccgggca  cttcaacct  aaggtaggt  caggaggtg  agggactgc  ctcttccct  360
acatctctt  cctctgact  caaggcaaa  cctacgagg  cctctggct  aagcagtat  420
atctgacca  gaggaaaca  gtggatctg  gctacatct  cctaccatg  ccctgtggt  480
ctccctctt  attaccaga  tccagagat  ctccctctc  gccaccaga  tcctctggt  540
ctccctctc  atctccc  557



<210> 10211
<211> 181
<212> PRT
<213> Rattus norvegicus
<308> CAA66043
<400> 10211

Met Lys Ile Leu Phe Cys Asp Val Leu Leu Leu Ser Leu Leu Ser Ser 
  1               5                  10                  15
Val Phe Ser Ser Cys Pro Glu Asp Cys Leu Thr Cys Gln Glu Arg Leu 
             20                  25                  30
His Pro Ala Pro Gly Ser Phe Asn Leu Lys Leu Cys Ile Leu Gln Cys 
         35                  40                  45
Glu Glu Lys Val Phe Pro Arg Pro Leu Trp Thr Leu Cys Thr Lys Ala 
     50                  55                  60
Met Ala Ser Asp Ser Glu Gln Leu Ser Pro Ala Asp Pro Glu Leu Thr 
 65                  70                  75                  80
Ser Ala Ala Leu Tyr Gln Ser Lys Ala Ser Glu Met Gln His Leu Lys 
                 85                  90                  95
Arg Met Pro Arg Val Arg Ser Val Val Gln Ala Arg Asp Ala Glu Pro 
             100                105                110
Glu Ala Asp Ala Glu Pro Val Ala Asp Glu Ala Asp Glu Val Glu Gln 
         115                120                125
Lys Gln Leu Gln Lys Arg Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser 
     130                135                140
Ala Arg Lys Leu Ala Asn Gln Lys Arg Phe Ser Glu Phe Met Arg Gln 
 145                150                155                160
Tyr Leu Val Leu Ser Met Gln Ser Ser Gln Arg Arg Arg Thr Leu His 
                 165                170                175
Gln Asn Gly Asn Val 
             180



<210> 10212
<211> 1198
<212> DNA
<213> Homo sapiens
<308> NM_006228
<400> 10212

gccaggaag  cttgcaggt  ctgctgttt  gttgctgaa  ggggtcagt  tgtgtatgt  60
tcatggagg  gggcaggga  ggggagggc  gtgcgtggg  gagatgagg  tatatatgc  120
ggtgtggct  agaaagcgg  accgagcct  gcatccatc  gagggagcc  gggactgac  180
gctctcagc  cctgcttcc  gctcctgca  catgaaagt  ctgctttgt  acctgctgc  240
gctcagtct  ttctccagt  tgttcagca  ttgtcagag  gactgtctc  catgccagg  300
gaagctcca  ccagccctg  acagcttcg  cctggaggt  tgcatcctc  agtgcgaag  360
gaaggtctt  cccagcccc  tctggactc  atgcaccaa  gtcatggcc  ggagctctt  420
gcagctcag  cctgccgcc  cagagcatg  ggcggctgc  ctctaccag  cgagagctt  480
ggagatgca  catctgcgg  gaatgcccc  agtccggag  ttgttccag  agcaggaag  540
gcccgagcc  ggcatggag  aggctggtg  gatggagca  aagcagctg  agaagagat  600
tgggggctt  accggggcc  ggaagtcgg  caggaagtt  gccaatcag  agcggttca  660
tgagtttat  aggcaatac  tggtcctga  catgcagtc  agccagcgc  ggcgcaccc  720
gcaccagaa  ggtaatgtg  agccggaag  ggcgctcct  ccagctgta  cggccactg  780
aacccatga  cgtccaggt  atcccccaa  cagcatgtg  tcagmccca  acctgccgc  840
tgggaatca  gattccttc  tccccaagg  actgagcgc  tgcagatcc  gcaggcttc  900
tttgcctcc  gaaccttcc  gtctgattg  tcctcccca  ccccctggc  tgtttcacc  960
caaccctgt  gctacatca  agtgtattt  tgtaattcc  ctagctacc  tttcaatag  1020
cccatctct  ctgctcacc  gcctcttgc  ccttctagg  gcaggtgaa  ggaatagga  1080
attgaacct  gggttttga  ttgccactg  cataacttg  ttgtaaaag  gctgttctt  1140
ttgactgat  gttttaaac  acgatttct  cattaaact  ctactgagc  aatggtta  1198



<210> 10213
<211> 176
<212> PRT
<213> Homo sapiens
<308> Q13519
<400> 10213

Met Lys Val Leu Leu Cys Asp Leu Leu Leu Leu Ser Leu Phe Ser Ser 
  1               5                  10                  15
Val Phe Ser Ser Cys Gln Arg Asp Cys Leu Thr Cys Gln Glu Lys Leu 
             20                  25                  30
His Pro Ala Leu Asp Ser Phe Asp Leu Glu Val Cys Ile Leu Glu Cys 
         35                  40                  45
Glu Glu Lys Val Phe Pro Ser Pro Leu Trp Thr Pro Cys Thr Lys Val 
     50                  55                  60
Met Ala Arg Ser Ser Trp Gln Leu Ser Pro Ala Ala Pro Glu His Val 
 65                  70                  75                  80
Ala Ala Ala Leu Tyr Gln Pro Arg Ala Ser Glu Met Gln His Leu Arg 
                 85                  90                  95
Arg Met Pro Arg Val Arg Ser Leu Phe Gln Glu Gln Glu Glu Pro Glu 
             100                105                110
Pro Gly Met Glu Glu Ala Gly Glu Met Glu Gln Lys Gln Leu Gln Lys 
         115                120                125
Arg Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg Lys Leu Ala 
     130                135                140
Asn Gln Lys Arg Phe Ser Glu Phe Met Arg Gln Tyr Leu Val Leu Ser 
 145                150                155                160
Met Gln Ser Ser Gln Arg Arg Arg Thr Leu His Gln Asn Gly Asn Val 
                 165                170                175



<210> 10214
<211> 1412
<212> DNA
<213> Rattus norvegicus
<308> X98399
<400> 10214

ggtgcctct  ctgcaccac  ctccagggc  ctgcacctc  taagagagc  tggctgccc  60
ttatcagac  ctgccttct  ccaccggga  gcccgctgg  gggagccag  ggaagaaat  120
gccatggaa  atattccca  tatggttaa  gtagaccga  gtgaaagcc  gattttatc  180
tgccggggg  gaaggtgtg  cctcaaagt  cttggctat  tcacgggag  tatgaagga  240
ttcgccaac  ggcttaaag  caagcctgt  gtgctccag  tcatggact  gatacttcg  300
ggcatatcc  aggtggtgt  tgtcagcaa  cccatcagt  gaatcctga  tctggcggg  360
cttctggtc  agaacccct  gtgggcgct  tgtggctgt  taggaaccg  ggtctccac  420
ctgaccgcc  tcttgctta  ccaagacag  tcagcgata  cggccgggc  ccagggtta  480
aatgccacc  tggtgggaa  actcatggc  gtcttctca  acaagggcg  ctacttctg  540
tggttgata  tccctgtat  tgctatgtc  atgacttgc  cggttttct  gagcgcgtt  600
agctccctg  tcagcaagt  ggacctgcc  gtcttcact  ttcctttca  catggcttt  660
tcgctgtac  ttccagcca  aggacacta  aatacgttt  tcccaagta  actcttcat  720
cctgtcagc  ccgtgccca  catcacgtg  tccgagctc  gcgccctgg  gctgttgaa  780
tctcttccg  tgggagtcg  tcagatata  ggctgtgat  acccgtgga  aggggccat  840
ttcctgtgt  ccatcctgc  ttcctcccc  ctcatgtgc  tgcacgctg  tatcggatc  900
ttgctggga  tcatcgcag  tctcagtct  gcagctccg  ttaaagata  cttctctgg  960
ctctggggt  tcaacagtt  cctggcttg  attgcgatc  gagggatgt  catggcact  1020
acctggcag  cccatctcc  ggcccttgc  tgtgccctg  tcactgcct  ctttggagc  1080
tgtatgaca  acctgatgg  tgcggttca  ctgccagct  gtacctggt  cttctgctt  1140
gccacacta  tctttctcc  gctgaccac  gaaaatccc  atatctaca  gatgcccct  1200
agcaaagtt  cctactccg  ggagaaccg  atcttctac  tacaaaaca  gaaaagggt  1260
gtcgactct  tgtgtgtac  tgtctgtgt  tgtggctgt  tgtgtatct  gcctgtgtg  1320
gtgcttctg  atgtgtatc  atgtgtctc  gtgtcttcg  gagtttgtg  gtatatgtg  1380
ctctgtatt  ctgtgggtg  gtgtgtgtg  cg  1412



<210> 10215
<211> 414
<212> PRT
<213> Rattus norvegicus
<308> CAA67049
<400> 10215

Met Ala Met Glu Asp Ile Pro Thr Met Val Lys Val Asp Arg Gly Glu 
  1               5                  10                  15
Ser Gln Ile Leu Ser Cys Arg Gly Arg Arg Cys Gly Leu Lys Val Leu 
             20                  25                  30
Gly Tyr Val Thr Gly Asp Met Lys Glu Phe Ala Asn Trp Leu Lys Asp 
         35                  40                  45
Lys Pro Val Val Leu Gln Phe Met Asp Trp Ile Leu Arg Gly Ile Ser 
     50                  55                  60
Gln Val Val Phe Val Ser Asn Pro Ile Ser Gly Ile Leu Ile Leu Ala 
 65                  70                  75                  80
Gly Leu Leu Val Gln Asn Pro Trp Trp Ala Leu Cys Gly Cys Val Gly 
                 85                  90                  95
Thr Val Val Ser Thr Leu Thr Ala Leu Leu Leu Ser Gln Asp Arg Ser 
             100                105                110
Ala Ile Thr Ala Gly Leu Gln Gly Tyr Asn Ala Thr Leu Val Gly Ile 
         115                120                125
Leu Met Ala Val Phe Ser Asp Lys Gly Asp Tyr Phe Trp Trp Leu Ile 
     130                135                140
Phe Pro Val Ser Ala Met Ser Met Thr Cys Pro Val Phe Ser Ser Ala 
 145                150                155                160
Leu Ser Ser Leu Phe Ser Lys Trp Asp Leu Pro Val Phe Thr Leu Pro 
                 165                170                175
Phe Asn Met Ala Leu Ser Leu Tyr Leu Pro Ala Thr Gly His Tyr Asn 
             180                185                190
Thr Phe Phe Pro Ser Lys Leu Phe Met Pro Val Ser Ser Val Pro Asn 
         195                200                205
Ile Thr Trp Ser Glu Leu Ser Ala Leu Glu Leu Leu Lys Ser Leu Pro 
     210                215                220
Val Gly Val Gly Gln Ile Tyr Gly Cys Asp Asn Pro Trp Thr Gly Ala 
 225                230                235                240
Ile Phe Leu Cys Ala Ile Leu Leu Ser Ser Pro Leu Met Cys Leu His 
                 245                250                255
Ala Ala Ile Gly Ser Leu Leu Gly Val Ile Ala Gly Leu Ser Leu Ala 
             260                265                270
Ala Pro Phe Lys Asp Ile Phe Ser Gly Leu Trp Gly Phe Asn Ser Ser 
         275                280                285
Leu Ala Cys Ile Ala Ile Gly Gly Met Phe Met Ala Leu Thr Trp Gln 
     290                295                300
Thr His Leu Leu Ala Leu Ala Cys Ala Leu Phe Thr Ala Tyr Phe Gly 
 305                310                315                320
Ala Cys Met Thr His Leu Met Ala Ala Val His Leu Pro Ala Cys Thr 
                 325                330                335
Trp Ser Phe Cys Leu Ala Thr Leu Leu Phe Leu Leu Leu Thr Thr Glu 
             340                345                350
Asn Pro Asn Ile Tyr Arg Met Pro Leu Ser Lys Val Thr Tyr Ser Glu 
         355                360                365
Glu Asn Arg Ile Phe Tyr Leu Gln Asn Lys Lys Arg Val Val Asp Ser 
     370                375                380
Val Cys Val His Val Cys Val Cys Gly Cys Met Cys Ile Leu Pro Val 
 385                390                395                400
Cys Val Leu Leu His Val Tyr Leu Cys Val Ser Val Ser Ser 
                 405                410



<210> 10216
<211> 1255
<212> DNA
<213> Homo sapiens
<308> Y19039
<400> 10216

gagccagag  aagagatag  catggagga  agccccact  tggttagag  ggacagccc  60
actatggtt  ggggtgaaa  ccaggtttc  ccatgtcaa  ggagaaggt  cttccccaa  120
gctcttggc  atgtcaccg  tgacatgaa  gaacttgcc  accagctta  agacaaacc  180
gtggtgctc  agttcattg  ctggattct  cggggcata  cccaagtgg  gttcgtcaa  240
aaccccgtc  gtggaatcc  gattctggt  ggacttctt  ttcagaacc  ctggtgggc  300
ctcactggc  ggctgggaa  agtggtctc  actctgatg  ccctcttgc  cagccagga  360
aggtcatta  tagcatctg  gctctatgg  tacaatgcc  ccctggtgg  agtactcat  420
gctgtcttt  cggacaagg  agactattt  tggtggctg  tactccctg  atgtgctat  480
tccatgact  gcccaattt  ctcaagtgc  ttgaattcc  tgctcagca  atgggacct  540
cccgtcttc  ccctccctt  caacatggc  ttgtcaatg  acctttcag  cacaggaca  600
tacaatccg  tctttccag  caaactggt  atacctata  ctacagctc  aaatatctc  660
tggtctgac  tcagtgccc  ggagttgtt  aaatctata  cagtgggag  tggtcagat  720
tatggctgt  ataatccat  gacaggggg  attttcctg  gagccatcc  actctcctc  780
ccactcatg  gcctgcatg  tgccatagg  tcattgctg  gcatagcag  gggactcag  840
ctttcagcc  catttgagg  catctactt  ggactctgg  gtttcaaca  ctctctggc  900
tgcattgca  tgggaggaa  gttcatggc  ctcacctgg  aaacccacc  cctggctct  960
ggctgtgcc  tgttcacgg  ctatcttgg  gtcggcatg  caaacttta  ggctgaggt  1020
ggattgcca  cttgtacct  gcccttctg  ttggccacg  tattgttcc  catcatgac  1080
acaaaaaat  ccaacatct  caagatgcc  ctcagtaaa  ttacttatc  tgaagaaaa  1140
cgcatcttc  acctgcaag  caagaaaag  atggtggaa  gccctttgt  agaacaagc  1200
ccatttgca  ccatggtca  gagtcattt  tgcctgact  ctccagcta  cttcc  1255



<210> 10217
<211> 389
<212> PRT
<213> Homo sapiens
<308> Q13336
<400> 10217

Met Glu Asp Ser Pro Thr Met Val Arg Val Asp Ser Pro Thr Met Val 
  1               5                  10                  15
Arg Gly Glu Asn Gln Val Ser Pro Cys Gln Gly Arg Arg Cys Phe Pro 
             20                  25                  30
Lys Ala Leu Gly Tyr Val Thr Gly Asp Met Lys Glu Leu Ala Asn Gln 
         35                  40                  45
Leu Lys Asp Lys Pro Val Val Leu Gln Phe Ile Asp Trp Ile Leu Arg 
     50                  55                  60
Gly Ile Ser Gln Val Val Phe Val Asn Asn Pro Val Ser Gly Ile Leu 
 65                  70                  75                  80
Ile Leu Val Gly Leu Leu Val Gln Asn Pro Trp Trp Ala Leu Thr Gly 
                 85                  90                  95
Trp Leu Gly Thr Val Val Ser Thr Leu Met Ala Leu Leu Leu Ser Gln 
             100                105                110
Asp Arg Ser Leu Ile Ala Ser Gly Leu Tyr Gly Tyr Asn Ala Thr Leu 
         115                120                125
Val Gly Val Leu Met Ala Val Phe Ser Asp Lys Gly Asp Tyr Phe Trp 
     130                135                140
Trp Leu Leu Leu Pro Val Cys Ala Met Ser Met Thr Cys Pro Ile Phe 
 145                150                155                160
Ser Ser Ala Leu Asn Ser Met Leu Ser Lys Trp Asp Leu Pro Val Phe 
                 165                170                175
Thr Leu Pro Phe Asn Met Ala Leu Ser Met Tyr Leu Ser Ala Thr Gly 
             180                185                190
His Tyr Asn Pro Phe Phe Pro Ala Lys Leu Val Ile Pro Ile Thr Thr 
         195                200                205
Ala Pro Asn Ile Ser Trp Ser Asp Leu Ser Ala Leu Glu Leu Leu Lys 
     210                215                220
Ser Ile Pro Val Gly Val Gly Gln Ile Tyr Gly Cys Asp Asn Pro Trp 
 225                230                235                240
Thr Gly Gly Ile Phe Leu Gly Ala Ile Leu Leu Ser Ser Pro Leu Met 
                 245                250                255
Cys Leu His Ala Ala Ile Gly Ser Leu Leu Gly Ile Ala Ala Gly Leu 
             260                265                270
Ser Leu Ser Ala Pro Phe Glu Asp Ile Tyr Phe Gly Leu Trp Gly Phe 
         275                280                285
Asn Ser Ser Leu Ala Cys Ile Ala Met Gly Gly Met Phe Met Ala Leu 
     290                295                300
Thr Trp Gln Thr His Leu Leu Ala Leu Gly Cys Ala Leu Phe Thr Ala 
 305                310                315                320
Tyr Leu Gly Val Gly Met Ala Asn Phe Met Ala Glu Val Gly Leu Pro 
                 325                330                335
Ala Cys Thr Trp Pro Phe Cys Leu Ala Thr Leu Leu Phe Leu Ile Met 
             340                345                350
Thr Thr Lys Asn Ser Asn Ile Tyr Lys Met Pro Leu Ser Lys Val Thr 
         355                360                365
Tyr Pro Glu Glu Asn Arg Ile Phe Tyr Leu Gln Ala Lys Lys Arg Met 
     370                375                380
Val Glu Ser Pro Leu 
 385



<210> 10218
<211> 2325
<212> DNA
<213> Rattus norvegicus
<308> X98564
<400> 10218

ggaattcgg  acgaggatg  atctgtcac  ccgcaaccg  ccgcttctg  actcgtcct  60
gctggacag  ggctccctg  cctcgctgg  ctccagcgt  ttctgcagc  agggcgaag  120
ggaaccctt  gctctgggg  actgcctta  ggtcaacgt  ggaggcagc  gcttcgtgc  180
ctctcagca  gctctgtcc  gcttcccgc  cacgcgcct  ggcaaactg  ccgtggtgg  240
ggcctccta  cgccgcctg  gcgccctgg  tgcagcccc  agccccttg  agctttgtg  300
tgatgccaa  ccggtagac  acgagtact  cttcgaccg  agctctcag  cattccgtt  360
tgtcctaca  tattatcgc  ctggccgct  gcacgtcat  gagcagctc  gtgcactct  420
ctttcttca  gagatccag  actggggca  cgatgaact  agcatcgac  cctgctgca  480
ggacagata  ttcagaaga  aggagctga  tgaaactct  gacttcaag  aggacacag  540
tgaccagga  agtcaacat  agagtgaac  ggacttctc  caaggacct  gtcctaccg  600
ccgacaaaa  ctctgggat  ttctggaga  gcctgggtc  tccacagca  cccggatct  660
tggagtgat  tccatcatt  ttgtggcag  gtccatcgt  aacatggcc  tgatgtcag  720
tgagctaag  tggctcaac  tacagctgc  ggagatttt  gagtatgtg  gcatcagtt  780
gttcaccgg  gagttcatt  tgcgcttcc  gtgtgtgaa  gacaggtgc  acttcctga  840
gaaggttcc  aacatcata  acctccttg  catcttgcc  ttctacata  ctcttctgg  900
ggaaagcct  agcggcagc  acaccaccc  agagctgga  aatgtagga  gtctggtcc  960
ggttttgag  ctccttaga  ctctgcgca  gctgaagct  ggaaggcat  ctacaggat  1020
gcgctcact  gggatgaca  tcacccagt  ctatgaaga  gtcggccta  tgctcctgt  1080
tctatctgt  ggaatttct  tattttcaa  aatagaata  tttgcagag  aaagcattc  1140
tgatacaac  ttcacaagt  ttccttgtg  atggtggtg  gccacaaca  ccatgacta  1200
agtaggata  ggggacatt  gaccagaca  cacgacagg  aaaatcgtg  ccttcatgt  1260
tattctatc  ggaatcctt  tcttggcct  gcctattgc  attattaat  atcgcttct  1320
tgcttgtta  ttcaccttg  aactcaagg  agcagctgt  agacagcgt  aagctctca  1380
gaagcttac  aagaatata  ccactgact  atacattag  gttaacctg  gggatatct  1440
tgcccggag  atcatggag  tgcttcgat  aaagggcag  gagagagcg  gtactagaa  1500
cagtggtgg  gatgatttc  ggttttaag  ttaccttca  cttatttac  aaacctatg  1560
acatttgac  ggattgatg  agccttgct  ctatggcta  ctgtatact  attatgatt  1620
tcttgacca  ttatcttct  tctggtgta  tttctagaa  atttaacat  tcctatagc  1680
tctactgat  attttaaca  acatgtctt  aacgtagcc  attaataca  ccaaaatca  1740
ttgggaaaa  aacacgtat  tgaattttg  agtatcaat  aatataatt  catacatca  1800
aatttaaag  atcatgtgt  attattctt  ggctttcag  agtgatgtt  tctgttttt  1860
catggaagt  gaactgcac  gtccatggg  agttggggc  gtgagcatt  aaaaataca  1920
agtgcatct  tttgtcatt  aaagatatt  tacaaataa  ttacttctt  ctctatcaa  1980
taaaactat  gagtataaa  ataagcttt  caatcaaac  cttaagctt  gtagccata  2040
tgagtacca  atcttccat  aagtgcaag  cactggttc  aactggaca  agctctacc  2100
ttcaacagt  aatttctaa  tggaagcct  aaactgctg  agacttgaa  taggtgaga  2160
ttcaagtcc  tggacaatt  cattatccc  gctgagtgt  atgtgtgaa  aagaatgca  2220
catagctct  tgggaaaat  aaatgattt  taaaacatt  cattatgga  gaattattt  2280
agctatgct  tcaaagtca  gaatatgga  aactaaacc  aattc  2325



<210> 10219
<211> 503
<212> PRT
<213> Rattus norvegicus
<308> CAA67174
<400> 10219

Met Asp Leu Ser Pro Arg Asn Arg Pro Leu Leu Asp Ser Ser Ser Leu 
  1               5                  10                  15
Asp Ser Gly Ser Leu Thr Ser Leu Asp Ser Ser Val Phe Cys Ser Glu 
             20                  25                  30
Gly Glu Gly Glu Pro Leu Ala Leu Gly Asp Cys Leu Thr Val Asn Val 
         35                  40                  45
Gly Gly Ser Arg Phe Val Leu Ser Gln Gln Ala Leu Ser Cys Phe Pro 
     50                  55                  60
His Thr Arg Leu Gly Lys Leu Ala Val Val Val Ala Ser Tyr Arg Arg 
 65                  70                  75                  80
Leu Gly Ala Leu Ala Ala Ala Pro Ser Pro Leu Glu Leu Cys Asp Asp 
                 85                  90                  95
Ala Asn Pro Val Asp Asn Glu Tyr Phe Phe Asp Arg Ser Ser Gln Ala 
             100                105                110
Phe Arg Tyr Val Leu His Tyr Tyr Arg Thr Gly Arg Leu His Val Met 
         115                120                125
Glu Gln Leu Cys Ala Leu Ser Phe Leu Gln Glu Ile Gln Tyr Trp Gly 
     130                135                140
Ile Asp Glu Leu Ser Ile Asp Ser Cys Cys Arg Asp Arg Tyr Phe Arg 
 145                150                155                160
Arg Lys Glu Leu Ser Glu Thr Leu Asp Phe Lys Lys Asp Thr Asp Asp 
                 165                170                175
Gln Glu Ser Gln His Glu Ser Glu Gln Asp Phe Ser Gln Gly Pro Cys 
             180                185                190
Pro Thr Val Arg Gln Lys Leu Trp Asp Ile Leu Glu Lys Pro Gly Ser 
         195                200                205
Ser Thr Ala Ala Arg Ile Phe Gly Val Ile Ser Ile Ile Phe Val Ala 
     210                215                220
Val Ser Ile Val Asn Met Ala Leu Met Ser Ala Glu Leu Ser Trp Leu 
 225                230                235                240
Asn Leu Gln Leu Leu Glu Ile Leu Glu Tyr Val Cys Ile Ser Trp Phe 
                 245                250                255
Thr Gly Glu Phe Ile Leu Arg Phe Leu Cys Val Lys Asp Arg Cys His 
             260                265                270
Phe Leu Arg Lys Val Pro Asn Ile Ile Asp Leu Leu Ala Ile Leu Pro 
         275                280                285
Phe Tyr Ile Thr Leu Leu Val Glu Ser Leu Ser Gly Ser His Thr Thr 
     290                295                300
Gln Glu Leu Glu Asn Val Gly Arg Leu Val Gln Val Leu Arg Leu Leu 
 305                310                315                320
Arg Ala Leu Arg Met Leu Lys Leu Gly Arg His Ser Thr Gly Leu Arg 
                 325                330                335
Ser Leu Gly Met Thr Ile Thr Gln Cys Tyr Glu Glu Val Gly Leu Leu 
             340                345                350
Leu Leu Phe Leu Ser Val Gly Ile Ser Ile Phe Ser Thr Ile Glu Tyr 
         355                360                365
Phe Ala Glu Gln Ser Ile Pro Asp Thr Thr Phe Thr Ser Val Pro Cys 
     370                375                380
Ala Trp Trp Trp Ala Thr Thr Ser Met Thr Thr Val Gly Tyr Gly Asp 
 385                390                395                400
Ile Arg Pro Asp Thr Thr Thr Gly Lys Ile Val Ala Phe Met Cys Ile 
                 405                410                415
Leu Ser Gly Ile Leu Val Leu Ala Leu Pro Ile Ala Ile Ile Asn Asp 
             420                425                430
Arg Phe Ser Ala Cys Tyr Phe Thr Leu Lys Leu Lys Glu Ala Ala Val 
         435                440                445
Arg Gln Arg Glu Ala Leu Lys Lys Leu Thr Lys Asn Ile Ala Thr Asp 
     450                455                460
Ser Tyr Ile Ser Val Asn Leu Arg Asp Ile Tyr Ala Arg Ser Ile Met 
 465                470                475                480
Glu Met Leu Arg Leu Lys Gly Arg Glu Arg Ala Ser Thr Arg Ser Ser 
                 485                490                495
Gly Gly Asp Asp Phe Trp Phe 
             500



<210> 10220
<211> 2942
<212> DNA
<213> Homo sapiens
<308> NM_014379
<400> 10220

ggtgacaac  tttggaagg  ccagggcga  cggcagtgt  cacagggac  gtgtcgggc  60
tggacctca  ctgatcctc  ctcttagcg  gacccttcc  ctgctccct  tctcctctt  120
ctgccactt  tgcgctgct  ccgcgcact  ccggctccc  agcggcagg  ggaggaagg  180
gcacagcgg  tggagaggg  gcgccaagg  gaggtaacc  cttcgggag  ccggggaat  240
ccggccgcc  ccaggggcc  tgccaccgc  ctcgcggga  caaagcttc  ggcgtgtcc  300
caactttgt  gcgccctca  gccgcggcg  ctgggttag  gatgccttc  agcggcaga  360
cgctgctgg  ctcgccgct  gacagcggc  ccctgacct  cctggactc  agtgtcttc  420
gcagcgagg  tgaagggga  cccttggcg  tcggggact  cttcacggt  aacgtgggc  480
gcagccgct  cgtgctctc  cagcaggcg  tgtcctgct  cccgcacac  cgccttggc  540
agctggccg  ggtggtggc  tcctaccgc  gccccgggg  cctggccgc  gtgcccagc  600
ctctggagc  ttgcgacga  gccaacccc  tggacaacg  gtacttctt  gaccgcagc  660
cgcaggcgt  ccgatatgt  ctgcactac  accgcaccg  ccgcctgca  gtcatggag  720
agctgtgcg  gctctcctt  ctgcaggag  tccagtact  gggcatcga  gagctcagc  780
tcgattcct  ctgcaggga  agatacttc  gaaggaaag  gctgagtga  actttagac  840
tcaagaagg  cacagaaga  caggaaagt  aacatgaga  tgaacagga  ttctcccaa  900
gaccttgtc  cactgttcg  cagaagctc  ggaatatcc  ggagaaacc  ggatcttcc  960
cagctgccc  tatctttgg  gtcatctcc  ttatcttcg  ggtggtgtc  atcattaac  1020
tggccctga  gtcagctga  ttaagctgg  tggacctgc  gctgctgga  atcctggag  1080
atgtgtgca  tagctggtt  accggggag  ttgtcctcc  cttcctgtg  gtgcgggac  1140
ggtgtcgct  cctaagaaa  gtgccaaac  tcatagacc  ccttgccat  ttgcccttc  1200
acatcactc  tctggtaga  agcctaagt  ggagccaga  cacgcagga  ctggagaac  1260
tggggcgca  tgtccaggt  ttgaggctg  tcagggctc  gcgcatgct  aagctgggc  1320
gacattcca  aggattacg  tcccttggg  tgacaatca  ccagtgtta  gaagaagtc  1380
gcctactgc  cctatttct  tccgtggga  tctctatat  ttcaactgt  gaatacttt  1440
ctgagcaaa  cattcctga  acaaccttc  caagtgtcc  ttgtgcatg  tggtgggcc  1500
ccacctcta  gactactgt  ggatatggg  acattagac  agacaccac  acaggcaaa  1560
tcgtggcct  catgtgtat  ttatcggga  ttcttgtct  ggccttgcc  attgctatt  1620
ttaacgatc  cttctctgc  tgctacttc  ccttgaaac  caaggaagc  gctgttaga  1680
agcgtgaag  cctaaagaa  cttaccaag  atatagcca  tgactcata  atcagtgtt  1740
acttgagag  tgtctatgc  cggagtatc  tggagatgc  gcgactgaa  ggcagagaa  1800
gagcaagta  taggagcag  gggggagat  atttctggt  ttgaattaa  tttcaattt  1860
tttacaaaa  ctatgtaca  ttaactaaa  tgataaagc  gtgatgtgg  tttctgtat  1920
ctgatgatg  gtctcttca  agtactgct  atcttaatt  atttttgct  atatattgc  1980
tcatctact  gaatatttc  catcaccta  aacaactgc  cagtgttct  acacatttg  2040
gtgtccaaa  tagccaatt  acacaacca  atacaactg  gccaatata  acatgtttg  2100
attgtcaaa  ataaaataa  gttattgca  tacatacaa  aaagttaaa  attttatgt  2160
tcactaaca  tagaagttt  ttgcaccac  aatttttta  aaatggaag  taaactgca  2220
agcccagag  aagataagt  aatatttaa  aacatattg  acaactttg  tatttaaag  2280
tattatcca  gtacataaa  tactccgtt  tctatcagt  aaagctatt  aatataata  2340
ttagcttta  aagagaaaa  ccatatttg  tgggcagag  ttatatccc  atcttcttt  2400
tcatgtaaa  cactggtca  aaatgaact  atctctgta  cccattatt  ctataagag  2460
tgggaatcc  aaaactgct  agattgcag  acatgagtt  acacaaaga  ttcaacaat  2520
gcacatctt  attctccca  ctgagtgta  tatgtggag  ataaaacag  atattctta  2580
tatttcatg  atatcagat  gtctttaaa  gtctcttta  ggatgtatt  ttcacatta  2640
ggctttaaa  taatgaata  gtaaaagtg  ggtagtgaa  atcctaaat  tctacactg  2700
aattactaa  taatcttat  tcataaaat  ggaaatata  gttaaatga  atcactgga  2760
gaacttgaa  atcttttac  tgttaacaa  aaaatacta  ggacagctt  ctgattgtt  2820
gggtaaata  caaatgttc  aactttgca  gcattttga  attcatcat  acaacacaa  2880
tcctagaca  tgtattata  aattaaagc  aaaacctct  aagctaaaa  aaaaaaaaa  2940
aa  2942



<210> 10221
<211> 500
<212> PRT
<213> Homo sapiens
<308> NP_055194
<400> 10221

Met Pro Ser Ser Gly Arg Ala Leu Leu Asp Ser Pro Leu Asp Ser Gly 
  1               5                  10                  15
Ser Leu Thr Ser Leu Asp Ser Ser Val Phe Cys Ser Glu Gly Glu Gly 
             20                  25                  30
Glu Pro Leu Ala Leu Gly Asp Cys Phe Thr Val Asn Val Gly Gly Ser 
         35                  40                  45
Arg Phe Val Leu Ser Gln Gln Ala Leu Ser Cys Phe Pro His Thr Arg 
     50                  55                  60
Leu Gly Lys Leu Ala Val Val Val Ala Ser Tyr Arg Arg Pro Gly Ala 
 65                  70                  75                  80
Leu Ala Ala Val Pro Ser Pro Leu Glu Leu Cys Asp Asp Ala Asn Pro 
                 85                  90                  95
Val Asp Asn Glu Tyr Phe Phe Asp Arg Ser Ser Gln Ala Phe Arg Tyr 
             100                105                110
Val Leu His Tyr Tyr Arg Thr Gly Arg Leu His Val Met Glu Gln Leu 
         115                120                125
Cys Ala Leu Ser Phe Leu Gln Glu Ile Gln Tyr Trp Gly Ile Asp Glu 
     130                135                140
Leu Ser Ile Asp Ser Cys Cys Arg Asp Arg Tyr Phe Arg Arg Lys Glu 
 145                150                155                160
Leu Ser Glu Thr Leu Asp Phe Lys Lys Asp Thr Glu Asp Gln Glu Ser 
                 165                170                175
Gln His Glu Ser Glu Gln Asp Phe Ser Gln Gly Pro Cys Pro Thr Val 
             180                185                190
Arg Gln Lys Leu Trp Asn Ile Leu Glu Lys Pro Gly Ser Ser Thr Ala 
         195                200                205
Ala Arg Ile Phe Gly Val Ile Ser Ile Ile Phe Val Val Val Ser Ile 
     210                215                220
Ile Asn Met Ala Leu Met Ser Ala Glu Leu Ser Trp Leu Asp Leu Gln 
 225                230                235                240
Leu Leu Glu Ile Leu Glu Tyr Val Cys Ile Ser Trp Phe Thr Gly Glu 
                 245                250                255
Phe Val Leu Arg Phe Leu Cys Val Arg Asp Arg Cys Arg Phe Leu Arg 
             260                265                270
Lys Val Pro Asn Ile Ile Asp Leu Leu Ala Ile Leu Pro Phe Tyr Ile 
         275                280                285
Thr Leu Leu Val Glu Ser Leu Ser Gly Ser Gln Thr Thr Gln Glu Leu 
     290                295                300
Glu Asn Val Gly Arg Ile Val Gln Val Leu Arg Leu Leu Arg Ala Leu 
 305                310                315                320
Arg Met Leu Lys Leu Gly Arg His Ser Thr Gly Leu Arg Ser Leu Gly 
                 325                330                335
Met Thr Ile Thr Gln Cys Tyr Glu Glu Val Gly Leu Leu Leu Leu Phe 
             340                345                350
Leu Ser Val Gly Ile Ser Ile Phe Ser Thr Val Glu Tyr Phe Ala Glu 
         355                360                365
Gln Ser Ile Pro Asp Thr Thr Phe Thr Ser Val Pro Cys Ala Trp Trp 
     370                375                380
Trp Ala Thr Thr Ser Met Thr Thr Val Gly Tyr Gly Asp Ile Arg Pro 
 385                390                395                400
Asp Thr Thr Thr Gly Lys Ile Val Ala Phe Met Cys Ile Leu Ser Gly 
                 405                410                415
Ile Leu Val Leu Ala Leu Pro Ile Ala Ile Ile Asn Asp Arg Phe Ser 
             420                425                430
Ala Cys Tyr Phe Thr Leu Lys Leu Lys Glu Ala Ala Val Arg Gln Arg 
         435                440                445
Glu Ala Leu Lys Lys Leu Thr Lys Asn Ile Ala Thr Asp Ser Tyr Ile 
     450                455                460
Ser Val Asn Leu Arg Asp Val Tyr Ala Arg Ser Ile Met Glu Met Leu 
 465                470                475                480
Arg Leu Lys Gly Arg Glu Arg Ala Ser Thr Arg Ser Ser Gly Gly Asp 
                 485                490                495
Asp Phe Trp Phe 
             500



<210> 10222
<211> 2325
<212> DNA
<213> Rattus norvegicus
<308> X98564
<400> 10222

ggaattcgg  acgaggatg  atctgtcac  ccgcaaccg  ccgcttctg  actcgtcct  60
gctggacag  ggctccctg  cctcgctgg  ctccagcgt  ttctgcagc  agggcgaag  120
ggaaccctt  gctctgggg  actgcctta  ggtcaacgt  ggaggcagc  gcttcgtgc  180
ctctcagca  gctctgtcc  gcttcccgc  cacgcgcct  ggcaaactg  ccgtggtgg  240
ggcctccta  cgccgcctg  gcgccctgg  tgcagcccc  agccccttg  agctttgtg  300
tgatgccaa  ccggtagac  acgagtact  cttcgaccg  agctctcag  cattccgtt  360
tgtcctaca  tattatcgc  ctggccgct  gcacgtcat  gagcagctc  gtgcactct  420
ctttcttca  gagatccag  actggggca  cgatgaact  agcatcgac  cctgctgca  480
ggacagata  ttcagaaga  aggagctga  tgaaactct  gacttcaag  aggacacag  540
tgaccagga  agtcaacat  agagtgaac  ggacttctc  caaggacct  gtcctaccg  600
ccgacaaaa  ctctgggat  ttctggaga  gcctgggtc  tccacagca  cccggatct  660
tggagtgat  tccatcatt  ttgtggcag  gtccatcgt  aacatggcc  tgatgtcag  720
tgagctaag  tggctcaac  tacagctgc  ggagatttt  gagtatgtg  gcatcagtt  780
gttcaccgg  gagttcatt  tgcgcttcc  gtgtgtgaa  gacaggtgc  acttcctga  840
gaaggttcc  aacatcata  acctccttg  catcttgcc  ttctacata  ctcttctgg  900
ggaaagcct  agcggcagc  acaccaccc  agagctgga  aatgtagga  gtctggtcc  960
ggttttgag  ctccttaga  ctctgcgca  gctgaagct  ggaaggcat  ctacaggat  1020
gcgctcact  gggatgaca  tcacccagt  ctatgaaga  gtcggccta  tgctcctgt  1080
tctatctgt  ggaatttct  tattttcaa  aatagaata  tttgcagag  aaagcattc  1140
tgatacaac  ttcacaagt  ttccttgtg  atggtggtg  gccacaaca  ccatgacta  1200
agtaggata  ggggacatt  gaccagaca  cacgacagg  aaaatcgtg  ccttcatgt  1260
tattctatc  ggaatcctt  tcttggcct  gcctattgc  attattaat  atcgcttct  1320
tgcttgtta  ttcaccttg  aactcaagg  agcagctgt  agacagcgt  aagctctca  1380
gaagcttac  aagaatata  ccactgact  atacattag  gttaacctg  gggatatct  1440
tgcccggag  atcatggag  tgcttcgat  aaagggcag  gagagagcg  gtactagaa  1500
cagtggtgg  gatgatttc  ggttttaag  ttaccttca  cttatttac  aaacctatg  1560
acatttgac  ggattgatg  agccttgct  ctatggcta  ctgtatact  attatgatt  1620
tcttgacca  ttatcttct  tctggtgta  tttctagaa  atttaacat  tcctatagc  1680
tctactgat  attttaaca  acatgtctt  aacgtagcc  attaataca  ccaaaatca  1740
ttgggaaaa  aacacgtat  tgaattttg  agtatcaat  aatataatt  catacatca  1800
aatttaaag  atcatgtgt  attattctt  ggctttcag  agtgatgtt  tctgttttt  1860
catggaagt  gaactgcac  gtccatggg  agttggggc  gtgagcatt  aaaaataca  1920
agtgcatct  tttgtcatt  aaagatatt  tacaaataa  ttacttctt  ctctatcaa  1980
taaaactat  gagtataaa  ataagcttt  caatcaaac  cttaagctt  gtagccata  2040
tgagtacca  atcttccat  aagtgcaag  cactggttc  aactggaca  agctctacc  2100
ttcaacagt  aatttctaa  tggaagcct  aaactgctg  agacttgaa  taggtgaga  2160
ttcaagtcc  tggacaatt  cattatccc  gctgagtgt  atgtgtgaa  aagaatgca  2220
catagctct  tgggaaaat  aaatgattt  taaaacatt  cattatgga  gaattattt  2280
agctatgct  tcaaagtca  gaatatgga  aactaaacc  aattc  2325



<210> 10223
<211> 503
<212> PRT
<213> Rattus norvegicus
<308> CAA67174
<400> 10223

Met Asp Leu Ser Pro Arg Asn Arg Pro Leu Leu Asp Ser Ser Ser Leu 
  1               5                  10                  15
Asp Ser Gly Ser Leu Thr Ser Leu Asp Ser Ser Val Phe Cys Ser Glu 
             20                  25                  30
Gly Glu Gly Glu Pro Leu Ala Leu Gly Asp Cys Leu Thr Val Asn Val 
         35                  40                  45
Gly Gly Ser Arg Phe Val Leu Ser Gln Gln Ala Leu Ser Cys Phe Pro 
     50                  55                  60
His Thr Arg Leu Gly Lys Leu Ala Val Val Val Ala Ser Tyr Arg Arg 
 65                  70                  75                  80
Leu Gly Ala Leu Ala Ala Ala Pro Ser Pro Leu Glu Leu Cys Asp Asp 
                 85                  90                  95
Ala Asn Pro Val Asp Asn Glu Tyr Phe Phe Asp Arg Ser Ser Gln Ala 
             100                105                110
Phe Arg Tyr Val Leu His Tyr Tyr Arg Thr Gly Arg Leu His Val Met 
         115                120                125
Glu Gln Leu Cys Ala Leu Ser Phe Leu Gln Glu Ile Gln Tyr Trp Gly 
     130                135                140
Ile Asp Glu Leu Ser Ile Asp Ser Cys Cys Arg Asp Arg Tyr Phe Arg 
 145                150                155                160
Arg Lys Glu Leu Ser Glu Thr Leu Asp Phe Lys Lys Asp Thr Asp Asp 
                 165                170                175
Gln Glu Ser Gln His Glu Ser Glu Gln Asp Phe Ser Gln Gly Pro Cys 
             180                185                190
Pro Thr Val Arg Gln Lys Leu Trp Asp Ile Leu Glu Lys Pro Gly Ser 
         195                200                205
Ser Thr Ala Ala Arg Ile Phe Gly Val Ile Ser Ile Ile Phe Val Ala 
     210                215                220
Val Ser Ile Val Asn Met Ala Leu Met Ser Ala Glu Leu Ser Trp Leu 
 225                230                235                240
Asn Leu Gln Leu Leu Glu Ile Leu Glu Tyr Val Cys Ile Ser Trp Phe 
                 245                250                255
Thr Gly Glu Phe Ile Leu Arg Phe Leu Cys Val Lys Asp Arg Cys His 
             260                265                270
Phe Leu Arg Lys Val Pro Asn Ile Ile Asp Leu Leu Ala Ile Leu Pro 
         275                280                285
Phe Tyr Ile Thr Leu Leu Val Glu Ser Leu Ser Gly Ser His Thr Thr 
     290                295                300
Gln Glu Leu Glu Asn Val Gly Arg Leu Val Gln Val Leu Arg Leu Leu 
 305                310                315                320
Arg Ala Leu Arg Met Leu Lys Leu Gly Arg His Ser Thr Gly Leu Arg 
                 325                330                335
Ser Leu Gly Met Thr Ile Thr Gln Cys Tyr Glu Glu Val Gly Leu Leu 
             340                345                350
Leu Leu Phe Leu Ser Val Gly Ile Ser Ile Phe Ser Thr Ile Glu Tyr 
         355                360                365
Phe Ala Glu Gln Ser Ile Pro Asp Thr Thr Phe Thr Ser Val Pro Cys 
     370                375                380
Ala Trp Trp Trp Ala Thr Thr Ser Met Thr Thr Val Gly Tyr Gly Asp 
 385                390                395                400
Ile Arg Pro Asp Thr Thr Thr Gly Lys Ile Val Ala Phe Met Cys Ile 
                 405                410                415
Leu Ser Gly Ile Leu Val Leu Ala Leu Pro Ile Ala Ile Ile Asn Asp 
             420                425                430
Arg Phe Ser Ala Cys Tyr Phe Thr Leu Lys Leu Lys Glu Ala Ala Val 
         435                440                445
Arg Gln Arg Glu Ala Leu Lys Lys Leu Thr Lys Asn Ile Ala Thr Asp 
     450                455                460
Ser Tyr Ile Ser Val Asn Leu Arg Asp Ile Tyr Ala Arg Ser Ile Met 
 465                470                475                480
Glu Met Leu Arg Leu Lys Gly Arg Glu Arg Ala Ser Thr Arg Ser Ser 
                 485                490                495
Gly Gly Asp Asp Phe Trp Phe 
             500



<210> 10224
<211> 2942
<212> DNA
<213> Homo sapiens
<308> NM_014379
<400> 10224

ggtgacaac  tttggaagg  ccagggcga  cggcagtgt  cacagggac  gtgtcgggc  60
tggacctca  ctgatcctc  ctcttagcg  gacccttcc  ctgctccct  tctcctctt  120
ctgccactt  tgcgctgct  ccgcgcact  ccggctccc  agcggcagg  ggaggaagg  180
gcacagcgg  tggagaggg  gcgccaagg  gaggtaacc  cttcgggag  ccggggaat  240
ccggccgcc  ccaggggcc  tgccaccgc  ctcgcggga  caaagcttc  ggcgtgtcc  300
caactttgt  gcgccctca  gccgcggcg  ctgggttag  gatgccttc  agcggcaga  360
cgctgctgg  ctcgccgct  gacagcggc  ccctgacct  cctggactc  agtgtcttc  420
gcagcgagg  tgaagggga  cccttggcg  tcggggact  cttcacggt  aacgtgggc  480
gcagccgct  cgtgctctc  cagcaggcg  tgtcctgct  cccgcacac  cgccttggc  540
agctggccg  ggtggtggc  tcctaccgc  gccccgggg  cctggccgc  gtgcccagc  600
ctctggagc  ttgcgacga  gccaacccc  tggacaacg  gtacttctt  gaccgcagc  660
cgcaggcgt  ccgatatgt  ctgcactac  accgcaccg  ccgcctgca  gtcatggag  720
agctgtgcg  gctctcctt  ctgcaggag  tccagtact  gggcatcga  gagctcagc  780
tcgattcct  ctgcaggga  agatacttc  gaaggaaag  gctgagtga  actttagac  840
tcaagaagg  cacagaaga  caggaaagt  aacatgaga  tgaacagga  ttctcccaa  900
gaccttgtc  cactgttcg  cagaagctc  ggaatatcc  ggagaaacc  ggatcttcc  960
cagctgccc  tatctttgg  gtcatctcc  ttatcttcg  ggtggtgtc  atcattaac  1020
tggccctga  gtcagctga  ttaagctgg  tggacctgc  gctgctgga  atcctggag  1080
atgtgtgca  tagctggtt  accggggag  ttgtcctcc  cttcctgtg  gtgcgggac  1140
ggtgtcgct  cctaagaaa  gtgccaaac  tcatagacc  ccttgccat  ttgcccttc  1200
acatcactc  tctggtaga  agcctaagt  ggagccaga  cacgcagga  ctggagaac  1260
tggggcgca  tgtccaggt  ttgaggctg  tcagggctc  gcgcatgct  aagctgggc  1320
gacattcca  aggattacg  tcccttggg  tgacaatca  ccagtgtta  gaagaagtc  1380
gcctactgc  cctatttct  tccgtggga  tctctatat  ttcaactgt  gaatacttt  1440
ctgagcaaa  cattcctga  acaaccttc  caagtgtcc  ttgtgcatg  tggtgggcc  1500
ccacctcta  gactactgt  ggatatggg  acattagac  agacaccac  acaggcaaa  1560
tcgtggcct  catgtgtat  ttatcggga  ttcttgtct  ggccttgcc  attgctatt  1620
ttaacgatc  cttctctgc  tgctacttc  ccttgaaac  caaggaagc  gctgttaga  1680
agcgtgaag  cctaaagaa  cttaccaag  atatagcca  tgactcata  atcagtgtt  1740
acttgagag  tgtctatgc  cggagtatc  tggagatgc  gcgactgaa  ggcagagaa  1800
gagcaagta  taggagcag  gggggagat  atttctggt  ttgaattaa  tttcaattt  1860
tttacaaaa  ctatgtaca  ttaactaaa  tgataaagc  gtgatgtgg  tttctgtat  1920
ctgatgatg  gtctcttca  agtactgct  atcttaatt  atttttgct  atatattgc  1980
tcatctact  gaatatttc  catcaccta  aacaactgc  cagtgttct  acacatttg  2040
gtgtccaaa  tagccaatt  acacaacca  atacaactg  gccaatata  acatgtttg  2100
attgtcaaa  ataaaataa  gttattgca  tacatacaa  aaagttaaa  attttatgt  2160
tcactaaca  tagaagttt  ttgcaccac  aatttttta  aaatggaag  taaactgca  2220
agcccagag  aagataagt  aatatttaa  aacatattg  acaactttg  tatttaaag  2280
tattatcca  gtacataaa  tactccgtt  tctatcagt  aaagctatt  aatataata  2340
ttagcttta  aagagaaaa  ccatatttg  tgggcagag  ttatatccc  atcttcttt  2400
tcatgtaaa  cactggtca  aaatgaact  atctctgta  cccattatt  ctataagag  2460
tgggaatcc  aaaactgct  agattgcag  acatgagtt  acacaaaga  ttcaacaat  2520
gcacatctt  attctccca  ctgagtgta  tatgtggag  ataaaacag  atattctta  2580
tatttcatg  atatcagat  gtctttaaa  gtctcttta  ggatgtatt  ttcacatta  2640
ggctttaaa  taatgaata  gtaaaagtg  ggtagtgaa  atcctaaat  tctacactg  2700
aattactaa  taatcttat  tcataaaat  ggaaatata  gttaaatga  atcactgga  2760
gaacttgaa  atcttttac  tgttaacaa  aaaatacta  ggacagctt  ctgattgtt  2820
gggtaaata  caaatgttc  aactttgca  gcattttga  attcatcat  acaacacaa  2880
tcctagaca  tgtattata  aattaaagc  aaaacctct  aagctaaaa  aaaaaaaaa  2940
aa  2942



<210> 10225
<211> 500
<212> PRT
<213> Homo sapiens
<308> NP_055194
<400> 10225

Met Pro Ser Ser Gly Arg Ala Leu Leu Asp Ser Pro Leu Asp Ser Gly 
  1               5                  10                  15
Ser Leu Thr Ser Leu Asp Ser Ser Val Phe Cys Ser Glu Gly Glu Gly 
             20                  25                  30
Glu Pro Leu Ala Leu Gly Asp Cys Phe Thr Val Asn Val Gly Gly Ser 
         35                  40                  45
Arg Phe Val Leu Ser Gln Gln Ala Leu Ser Cys Phe Pro His Thr Arg 
     50                  55                  60
Leu Gly Lys Leu Ala Val Val Val Ala Ser Tyr Arg Arg Pro Gly Ala 
 65                  70                  75                  80
Leu Ala Ala Val Pro Ser Pro Leu Glu Leu Cys Asp Asp Ala Asn Pro 
                 85                  90                  95
Val Asp Asn Glu Tyr Phe Phe Asp Arg Ser Ser Gln Ala Phe Arg Tyr 
             100                105                110
Val Leu His Tyr Tyr Arg Thr Gly Arg Leu His Val Met Glu Gln Leu 
         115                120                125
Cys Ala Leu Ser Phe Leu Gln Glu Ile Gln Tyr Trp Gly Ile Asp Glu 
     130                135                140
Leu Ser Ile Asp Ser Cys Cys Arg Asp Arg Tyr Phe Arg Arg Lys Glu 
 145                150                155                160
Leu Ser Glu Thr Leu Asp Phe Lys Lys Asp Thr Glu Asp Gln Glu Ser 
                 165                170                175
Gln His Glu Ser Glu Gln Asp Phe Ser Gln Gly Pro Cys Pro Thr Val 
             180                185                190
Arg Gln Lys Leu Trp Asn Ile Leu Glu Lys Pro Gly Ser Ser Thr Ala 
         195                200                205
Ala Arg Ile Phe Gly Val Ile Ser Ile Ile Phe Val Val Val Ser Ile 
     210                215                220
Ile Asn Met Ala Leu Met Ser Ala Glu Leu Ser Trp Leu Asp Leu Gln 
 225                230                235                240
Leu Leu Glu Ile Leu Glu Tyr Val Cys Ile Ser Trp Phe Thr Gly Glu 
                 245                250                255
Phe Val Leu Arg Phe Leu Cys Val Arg Asp Arg Cys Arg Phe Leu Arg 
             260                265                270
Lys Val Pro Asn Ile Ile Asp Leu Leu Ala Ile Leu Pro Phe Tyr Ile 
         275                280                285
Thr Leu Leu Val Glu Ser Leu Ser Gly Ser Gln Thr Thr Gln Glu Leu 
     290                295                300
Glu Asn Val Gly Arg Ile Val Gln Val Leu Arg Leu Leu Arg Ala Leu 
 305                310                315                320
Arg Met Leu Lys Leu Gly Arg His Ser Thr Gly Leu Arg Ser Leu Gly 
                 325                330                335
Met Thr Ile Thr Gln Cys Tyr Glu Glu Val Gly Leu Leu Leu Leu Phe 
             340                345                350
Leu Ser Val Gly Ile Ser Ile Phe Ser Thr Val Glu Tyr Phe Ala Glu 
         355                360                365
Gln Ser Ile Pro Asp Thr Thr Phe Thr Ser Val Pro Cys Ala Trp Trp 
     370                375                380
Trp Ala Thr Thr Ser Met Thr Thr Val Gly Tyr Gly Asp Ile Arg Pro 
 385                390                395                400
Asp Thr Thr Thr Gly Lys Ile Val Ala Phe Met Cys Ile Leu Ser Gly 
                 405                410                415
Ile Leu Val Leu Ala Leu Pro Ile Ala Ile Ile Asn Asp Arg Phe Ser 
             420                425                430
Ala Cys Tyr Phe Thr Leu Lys Leu Lys Glu Ala Ala Val Arg Gln Arg 
         435                440                445
Glu Ala Leu Lys Lys Leu Thr Lys Asn Ile Ala Thr Asp Ser Tyr Ile 
     450                455                460
Ser Val Asn Leu Arg Asp Val Tyr Ala Arg Ser Ile Met Glu Met Leu 
 465                470                475                480
Arg Leu Lys Gly Arg Glu Arg Ala Ser Thr Arg Ser Ser Gly Gly Asp 
                 485                490                495
Asp Phe Trp Phe 
             500



<210> 10226
<211> 2088
<212> DNA
<213> Rattus norvegicus
<308> X99267
<400> 10226

ccggcggag  agctgtttc  ttaaggttg  gcctctgat  agctgggaa  ccagcagaa  60
gcaaaggtt  ctgttgatg  cttctcacc  gccctgggc  gtgaccgcc  gggagagac  120
atgctcaca  tcatggcca  tgatagcga  gaagaggtg  gcgatgagc  gacgtcctt  180
atgtcagcc  agagcccta  atcacgttc  tgccaggac  gcaggccag  cccagagga  240
ggagagaac  ctgcccagt  gaggagcca  gagaacgag  acgactgtg  ggaggaccc  300
gaccactat  cctgcagtg  ggttcctgg  cgaccatcg  gcctggagg  ggagctgac  360
ctcaagtat  gggcgaagc  cgtgatcat  ctgttcgtg  ctgtcacgc  gtgcatgat  420
gtggtggtg  ccaccatca  gtccgtgcg  ttctacacg  agaagaacg  gcagctcat  480
tacacgccc  tcaccgagg  cacaccctc  gtgggccag  ggctcctca  ctccgtgct  540
aacactctg  tcatgatca  cgtcattgt  gtcatgact  tcttcctag  ggtactcta  600
aaatatcgc  gttacaagt  catccatgg  tggctgatc  tgtcctccc  gatgctcct  660
ttcttgttc  cctacatct  cctcgggga  gtgttcaag  cctacaatg  ggccatgga  720
taccccaca  tgttcctgg  tgtctggaa  ttcggggca  tgggcatgg  gtgcatcca  780
tggaagggt  ccctggtgc  ccagcaggc  tacctcatt  tgatcagcg  actcatggc  840
ctggtgttc  tcaagtacc  gccggagtg  tccgcttgg  tcatcttgg  cgccatctc  900
gtgtacgat  tcgtggctg  gctgtgccc  aaagggcca  tgaggatgc  ggtggaaac  960
gcccaggaa  gaaacgagc  catatttcc  gccctcata  actcatctg  catggtgtg  1020
acggtaggc  tggcgaagc  ggacccctc  tctcaggga  cactgcagc  cccttacga  1080
ccagagatg  aagaagact  ctatgacag  tttggggaa  cctcatacc  tgaagcctt  1140
gaagctccc  agcctggct  cccagggga  gagccggag  aggaggagg  aaggggtgt  1200
aagcttggt  tgggagact  catcttcta  agcgttctg  tgggcaagg  agcagccac  1260
ggcaacgga  actggagca  gacgctggc  tgctttatc  ccatcctca  tggcttgtg  1320
ctcaccctc  tgctgctcg  cgtgttcaa  aaggccctg  ccgccctcc  catctccat  1380
accttcggg  tcatctttt  cttctccac  gacaacctg  tgcgtcctt  catggacac  1440
ttggcctcc  accagctct  catctgaca  aagagctgc  gctctgaga  ctgtaggac  1500
cttcgccga  tgcaggtgt  tagttttac  ctctagtgc  atatatttt  ttttaaaaa  1560
acctttctt  ccttacaaa  gaaaaaaaa  gaataaaaa  gtgttgtgt  tacttcgtg  1620
cgaggaagc  gaagccgcc  ttctgtgct  gctgtcttg  caccagact  aggcttgcc  1680
gtcagagca  ctgtggcac  cgcaggtgg  atgctgggc  aacaagcct  tcttcaggg  1740
tgaggtcac  tgtgtggat  aggttggag  ggacgcagg  cccatccag  tctgtaatc  1800
atccttcag  gctgagcag  aggaacatg  gcgtcagtg  ggaccagga  gcacggtca  1860
gaaggacgc  aagcaccaa  accctgacc  gaggacaaa  gccagtttg  cgtcatgaa  1920
gcccccagt  ctttgtttg  gatgtctgt  acctttagt  tcttagaag  tgagtcctg  1980
tcttatttc  gcagtggac  gctgggaag  ggcttaatg  caataccaa  acatagatg  2040
ccctgctgg  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  2088



<210> 10227
<211> 448
<212> PRT
<213> Rattus norvegicus
<308> O88777
<400> 10227

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
  1               5                  10                  15
Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Ser Arg Ser Cys Gln 
             20                  25                  30
Asp Ser Arg Pro Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
         35                  40                  45
Ser Gln Glu Asn Glu Asp Asp Cys Glu Glu Asp Pro Asp His Tyr Ala 
     50                  55                  60
Cys Ser Gly Val Pro Gly Arg Pro Ser Gly Leu Glu Glu Glu Leu Thr 
 65                  70                  75                  80
Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                 85                  90                  95
Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
             100                105                110
Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
         115                120                125
Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
     130                135                140
Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
 145                150                155                160
Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                 165                170                175
Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Phe 
             180                185                190
Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Phe Leu Ala Val 
         195                200                205
Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
     210                215                220
Leu Val Leu Gln Gln Ala Tyr Leu Ile Val Ile Ser Ala Leu Met Ala 
 225                230                235                240
Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                 245                250                255
Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
             260                265                270
Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
         275                280                285
Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
     290                295                300
Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
 305                310                315                320
Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                 325                330                335
Pro Glu Ala Phe Glu Ala Pro Gln Pro Gly Tyr Pro Gly Glu Glu Pro 
             340                345                350
Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
         355                360                365
Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Asn Gly Asp 
     370                375                380
Trp Ser Thr Thr Leu Ala Cys Phe Ile Ala Ile Leu Ile Gly Leu Cys 
 385                390                395                400
Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                 405                410                415
Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
             420                425                430
Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
         435                440                445



<210> 10228
<211> 2236
<212> DNA
<213> Homo sapiens
<308> L43964
<400> 10228

cgagcggcg  cggagcagg  atttccagc  gtgaggaga  agccagaag  aagctattg  60
agctgaagg  acctgagac  gaagctagt  ccccctctg  attttactg  tgaagaaac  120
gaggccaca  agctaaagt  acttttccc  aggtcgccc  gcgaggacg  gggacttct  180
agacgtcag  agagtgatg  gagggagct  tgtgaccat  gaaagtgac  tgttaaaaa  240
cagcgctgc  ctctttgaa  gccagggag  atcattcat  tagcctgct  agaagaaga  300
accaagtgt  cgggattca  acctctctg  ggccccaag  gttcgtggt  cttccagag  360
cagggctat  ctcacattc  tggcctctg  cagcgagga  gaagtgtgt  atgagcgga  420
gtccctaat  tcggccgag  gccccacgc  gcgctcctg  caggagggc  ggcagggcc  480
agaggatgg  gagaacact  cccagtgga  aagccagga  aacgaggag  acggtgagg  540
ggaccctga  cgctatgtc  gtagtgggg  tcccgggcg  ccgccaggc  tggaggaag  600
gctgaccct  aaatacgga  cgaagcacg  gatcatgct  tttgtgcct  tcactctgt  660
catgatcgt  gtggtagcc  ccatcaagt  tgtgcgctt  tacacagag  agaatggac  720
gctcatcta  acgacattc  ctgaggaca  accctcggt  ggccagcgc  tcctcaact  780
cgtgctgaa  accctcatc  tgatcagcg  catcgtggt  atgaccatc  tcttggtgg  840
gctctacaa  taccgctgc  acaagttca  ccatggctg  ttgatcatg  cttcactga  900
gctgctgtt  ctcttcacc  atatctacc  tggggaagt  ctcaagacc  acaatgtgg  960
catggacta  cccaccctc  tgctgactg  ctggaactt  ggggcagtg  gcatggtgt  1020
catccactg  aagggccct  tggtgctgc  gcaggccta  ctcatcatg  tcagtgcgc  1080
catggccct  gtgttcatc  agtacctcc  agagtggtc  gcgtgggtc  tcctgggcg  1140
catctctgt  tatgatctc  tggctgtgc  gtgtcccaa  gggcctctg  gaatgctgg  1200
agaaactgc  caggagaga  atgagccca  attccctgc  ctgatatac  catctgcca  1260
ggtgtggac  gttggcatg  cgaagctgg  cccctcctc  cagggtgcc  tccagctcc  1320
ctacgaccc  gagatggaa  aagactcct  tgacagttt  ggggagcct  cataccccg  1380
agtctttga  cctcccttg  ctggctacc  aggggagga  ctggaggaa  aggaggaaa  1440
gggcgtgaa  cttggcctc  gggacttca  cttctacag  gtgctggtg  gcaaggcgg  1500
tgccacggg  agcggggac  ggaatacca  gctggcctg  ttcgtggcc  tcctcattg  1560
cttgtgtct  accctcctg  tgcttgctg  gttcaagaa  gcgctgccc  ccctcccca  1620
ctccatcac  ttcgggctc  tcttttact  ctccacgga  aacctggtg  ggccgttca  1680
ggacaccct  gcctcccat  agctctaca  ctgagggac  tggtgtgcc  caggctgca  1740
gctgcaggg  attttcatt  gatgcagtt  tatagtttt  cactctagt  ccatatatt  1800
ttaagactt  tctttcctt  aaaaataaa  tacgtgttt  cttggtgag  aggaggcag  1860
accagctct  tggtgccag  tgtttcatc  ccagacttt  gctcccgct  tggggagcg  1920
ctcgcttca  ggacaggaa  cacagcagg  ttatccaga  gaactgaga  ggtcagatt  1980
gggcgggga  aagagcatc  ggcatgagg  ctgagatgc  caaagagtg  gctcgggag  2040
ggcccctgg  acctgggtg  tctggctgg  gaggaaaag  cagttccct  cgaggagtg  2100
tcccaatgc  ttgtccatg  tgtccttgt  attttattg  ctttagaaa  tgagtcctg  2160
tcttgttac  gcagtcaca  tgctgggaa  tggcttaat  gtaatatca  taaatagat  2220
agtcctgtt  gaaaaa  2236



<210> 10229
<211> 448
<212> PRT
<213> Homo sapiens
<308> P49810
<400> 10229

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
  1               5                  10                  15
Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
             20                  25                  30
Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
         35                  40                  45
Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
     50                  55                  60
Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
 65                  70                  75                  80
Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                 85                  90                  95
Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
             100                105                110
Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
         115                120                125
Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
     130                135                140
Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
 145                150                155                160
Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                 165                170                175
Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
             180                185                190
Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
         195                200                205
Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
     210                215                220
Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
 225                230                235                240
Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                 245                250                255
Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
             260                265                270
Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
         275                280                285
Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
     290                295                300
Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
 305                310                315                320
Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                 325                330                335
Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
             340                345                350
Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
         355                360                365
Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
     370                375                380
Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys 
 385                390                395                400
Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                 405                410                415
Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
             420                425                430
Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
         435                440                445



<210> 10230
<211> 2088
<212> DNA
<213> Rattus norvegicus
<308> X99267
<400> 10230

ccggcggag  agctgtttc  ttaaggttg  gcctctgat  agctgggaa  ccagcagaa  60
gcaaaggtt  ctgttgatg  cttctcacc  gccctgggc  gtgaccgcc  gggagagac  120
atgctcaca  tcatggcca  tgatagcga  gaagaggtg  gcgatgagc  gacgtcctt  180
atgtcagcc  agagcccta  atcacgttc  tgccaggac  gcaggccag  cccagagga  240
ggagagaac  ctgcccagt  gaggagcca  gagaacgag  acgactgtg  ggaggaccc  300
gaccactat  cctgcagtg  ggttcctgg  cgaccatcg  gcctggagg  ggagctgac  360
ctcaagtat  gggcgaagc  cgtgatcat  ctgttcgtg  ctgtcacgc  gtgcatgat  420
gtggtggtg  ccaccatca  gtccgtgcg  ttctacacg  agaagaacg  gcagctcat  480
tacacgccc  tcaccgagg  cacaccctc  gtgggccag  ggctcctca  ctccgtgct  540
aacactctg  tcatgatca  cgtcattgt  gtcatgact  tcttcctag  ggtactcta  600
aaatatcgc  gttacaagt  catccatgg  tggctgatc  tgtcctccc  gatgctcct  660
ttcttgttc  cctacatct  cctcgggga  gtgttcaag  cctacaatg  ggccatgga  720
taccccaca  tgttcctgg  tgtctggaa  ttcggggca  tgggcatgg  gtgcatcca  780
tggaagggt  ccctggtgc  ccagcaggc  tacctcatt  tgatcagcg  actcatggc  840
ctggtgttc  tcaagtacc  gccggagtg  tccgcttgg  tcatcttgg  cgccatctc  900
gtgtacgat  tcgtggctg  gctgtgccc  aaagggcca  tgaggatgc  ggtggaaac  960
gcccaggaa  gaaacgagc  catatttcc  gccctcata  actcatctg  catggtgtg  1020
acggtaggc  tggcgaagc  ggacccctc  tctcaggga  cactgcagc  cccttacga  1080
ccagagatg  aagaagact  ctatgacag  tttggggaa  cctcatacc  tgaagcctt  1140
gaagctccc  agcctggct  cccagggga  gagccggag  aggaggagg  aaggggtgt  1200
aagcttggt  tgggagact  catcttcta  agcgttctg  tgggcaagg  agcagccac  1260
ggcaacgga  actggagca  gacgctggc  tgctttatc  ccatcctca  tggcttgtg  1320
ctcaccctc  tgctgctcg  cgtgttcaa  aaggccctg  ccgccctcc  catctccat  1380
accttcggg  tcatctttt  cttctccac  gacaacctg  tgcgtcctt  catggacac  1440
ttggcctcc  accagctct  catctgaca  aagagctgc  gctctgaga  ctgtaggac  1500
cttcgccga  tgcaggtgt  tagttttac  ctctagtgc  atatatttt  ttttaaaaa  1560
acctttctt  ccttacaaa  gaaaaaaaa  gaataaaaa  gtgttgtgt  tacttcgtg  1620
cgaggaagc  gaagccgcc  ttctgtgct  gctgtcttg  caccagact  aggcttgcc  1680
gtcagagca  ctgtggcac  cgcaggtgg  atgctgggc  aacaagcct  tcttcaggg  1740
tgaggtcac  tgtgtggat  aggttggag  ggacgcagg  cccatccag  tctgtaatc  1800
atccttcag  gctgagcag  aggaacatg  gcgtcagtg  ggaccagga  gcacggtca  1860
gaaggacgc  aagcaccaa  accctgacc  gaggacaaa  gccagtttg  cgtcatgaa  1920
gcccccagt  ctttgtttg  gatgtctgt  acctttagt  tcttagaag  tgagtcctg  1980
tcttatttc  gcagtggac  gctgggaag  ggcttaatg  caataccaa  acatagatg  2040
ccctgctgg  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  2088



<210> 10231
<211> 448
<212> PRT
<213> Rattus norvegicus
<308> O88777
<400> 10231

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
  1               5                  10                  15
Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Ser Arg Ser Cys Gln 
             20                  25                  30
Asp Ser Arg Pro Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
         35                  40                  45
Ser Gln Glu Asn Glu Asp Asp Cys Glu Glu Asp Pro Asp His Tyr Ala 
     50                  55                  60
Cys Ser Gly Val Pro Gly Arg Pro Ser Gly Leu Glu Glu Glu Leu Thr 
 65                  70                  75                  80
Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                 85                  90                  95
Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
             100                105                110
Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
         115                120                125
Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
     130                135                140
Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
 145                150                155                160
Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                 165                170                175
Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Phe 
             180                185                190
Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Phe Leu Ala Val 
         195                200                205
Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
     210                215                220
Leu Val Leu Gln Gln Ala Tyr Leu Ile Val Ile Ser Ala Leu Met Ala 
 225                230                235                240
Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                 245                250                255
Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
             260                265                270
Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
         275                280                285
Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
     290                295                300
Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
 305                310                315                320
Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                 325                330                335
Pro Glu Ala Phe Glu Ala Pro Gln Pro Gly Tyr Pro Gly Glu Glu Pro 
             340                345                350
Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
         355                360                365
Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Asn Gly Asp 
     370                375                380
Trp Ser Thr Thr Leu Ala Cys Phe Ile Ala Ile Leu Ile Gly Leu Cys 
 385                390                395                400
Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                 405                410                415
Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
             420                425                430
Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
         435                440                445



<210> 10232
<211> 2236
<212> DNA
<213> Homo sapiens
<308> L43964
<400> 10232

cgagcggcg  cggagcagg  atttccagc  gtgaggaga  agccagaag  aagctattg  60
agctgaagg  acctgagac  gaagctagt  ccccctctg  attttactg  tgaagaaac  120
gaggccaca  agctaaagt  acttttccc  aggtcgccc  gcgaggacg  gggacttct  180
agacgtcag  agagtgatg  gagggagct  tgtgaccat  gaaagtgac  tgttaaaaa  240
cagcgctgc  ctctttgaa  gccagggag  atcattcat  tagcctgct  agaagaaga  300
accaagtgt  cgggattca  acctctctg  ggccccaag  gttcgtggt  cttccagag  360
cagggctat  ctcacattc  tggcctctg  cagcgagga  gaagtgtgt  atgagcgga  420
gtccctaat  tcggccgag  gccccacgc  gcgctcctg  caggagggc  ggcagggcc  480
agaggatgg  gagaacact  cccagtgga  aagccagga  aacgaggag  acggtgagg  540
ggaccctga  cgctatgtc  gtagtgggg  tcccgggcg  ccgccaggc  tggaggaag  600
gctgaccct  aaatacgga  cgaagcacg  gatcatgct  tttgtgcct  tcactctgt  660
catgatcgt  gtggtagcc  ccatcaagt  tgtgcgctt  tacacagag  agaatggac  720
gctcatcta  acgacattc  ctgaggaca  accctcggt  ggccagcgc  tcctcaact  780
cgtgctgaa  accctcatc  tgatcagcg  catcgtggt  atgaccatc  tcttggtgg  840
gctctacaa  taccgctgc  acaagttca  ccatggctg  ttgatcatg  cttcactga  900
gctgctgtt  ctcttcacc  atatctacc  tggggaagt  ctcaagacc  acaatgtgg  960
catggacta  cccaccctc  tgctgactg  ctggaactt  ggggcagtg  gcatggtgt  1020
catccactg  aagggccct  tggtgctgc  gcaggccta  ctcatcatg  tcagtgcgc  1080
catggccct  gtgttcatc  agtacctcc  agagtggtc  gcgtgggtc  tcctgggcg  1140
catctctgt  tatgatctc  tggctgtgc  gtgtcccaa  gggcctctg  gaatgctgg  1200
agaaactgc  caggagaga  atgagccca  attccctgc  ctgatatac  catctgcca  1260
ggtgtggac  gttggcatg  cgaagctgg  cccctcctc  cagggtgcc  tccagctcc  1320
ctacgaccc  gagatggaa  aagactcct  tgacagttt  ggggagcct  cataccccg  1380
agtctttga  cctcccttg  ctggctacc  aggggagga  ctggaggaa  aggaggaaa  1440
gggcgtgaa  cttggcctc  gggacttca  cttctacag  gtgctggtg  gcaaggcgg  1500
tgccacggg  agcggggac  ggaatacca  gctggcctg  ttcgtggcc  tcctcattg  1560
cttgtgtct  accctcctg  tgcttgctg  gttcaagaa  gcgctgccc  ccctcccca  1620
ctccatcac  ttcgggctc  tcttttact  ctccacgga  aacctggtg  ggccgttca  1680
ggacaccct  gcctcccat  agctctaca  ctgagggac  tggtgtgcc  caggctgca  1740
gctgcaggg  attttcatt  gatgcagtt  tatagtttt  cactctagt  ccatatatt  1800
ttaagactt  tctttcctt  aaaaataaa  tacgtgttt  cttggtgag  aggaggcag  1860
accagctct  tggtgccag  tgtttcatc  ccagacttt  gctcccgct  tggggagcg  1920
ctcgcttca  ggacaggaa  cacagcagg  ttatccaga  gaactgaga  ggtcagatt  1980
gggcgggga  aagagcatc  ggcatgagg  ctgagatgc  caaagagtg  gctcgggag  2040
ggcccctgg  acctgggtg  tctggctgg  gaggaaaag  cagttccct  cgaggagtg  2100
tcccaatgc  ttgtccatg  tgtccttgt  attttattg  ctttagaaa  tgagtcctg  2160
tcttgttac  gcagtcaca  tgctgggaa  tggcttaat  gtaatatca  taaatagat  2220
agtcctgtt  gaaaaa  2236



<210> 10233
<211> 448
<212> PRT
<213> Homo sapiens
<308> P49810
<400> 10233

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
  1               5                  10                  15
Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
             20                  25                  30
Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
         35                  40                  45
Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
     50                  55                  60
Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
 65                  70                  75                  80
Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                 85                  90                  95
Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
             100                105                110
Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
         115                120                125
Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
     130                135                140
Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
 145                150                155                160
Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                 165                170                175
Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
             180                185                190
Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
         195                200                205
Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
     210                215                220
Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
 225                230                235                240
Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                 245                250                255
Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
             260                265                270
Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
         275                280                285
Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
     290                295                300
Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
 305                310                315                320
Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                 325                330                335
Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
             340                345                350
Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
         355                360                365
Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
     370                375                380
Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys 
 385                390                395                400
Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                 405                410                415
Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
             420                425                430
Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
         435                440                445



<210> 10234
<211> 2088
<212> DNA
<213> Rattus norvegicus
<308> X99267
<400> 10234

ccggcggag  agctgtttc  ttaaggttg  gcctctgat  agctgggaa  ccagcagaa  60
gcaaaggtt  ctgttgatg  cttctcacc  gccctgggc  gtgaccgcc  gggagagac  120
atgctcaca  tcatggcca  tgatagcga  gaagaggtg  gcgatgagc  gacgtcctt  180
atgtcagcc  agagcccta  atcacgttc  tgccaggac  gcaggccag  cccagagga  240
ggagagaac  ctgcccagt  gaggagcca  gagaacgag  acgactgtg  ggaggaccc  300
gaccactat  cctgcagtg  ggttcctgg  cgaccatcg  gcctggagg  ggagctgac  360
ctcaagtat  gggcgaagc  cgtgatcat  ctgttcgtg  ctgtcacgc  gtgcatgat  420
gtggtggtg  ccaccatca  gtccgtgcg  ttctacacg  agaagaacg  gcagctcat  480
tacacgccc  tcaccgagg  cacaccctc  gtgggccag  ggctcctca  ctccgtgct  540
aacactctg  tcatgatca  cgtcattgt  gtcatgact  tcttcctag  ggtactcta  600
aaatatcgc  gttacaagt  catccatgg  tggctgatc  tgtcctccc  gatgctcct  660
ttcttgttc  cctacatct  cctcgggga  gtgttcaag  cctacaatg  ggccatgga  720
taccccaca  tgttcctgg  tgtctggaa  ttcggggca  tgggcatgg  gtgcatcca  780
tggaagggt  ccctggtgc  ccagcaggc  tacctcatt  tgatcagcg  actcatggc  840
ctggtgttc  tcaagtacc  gccggagtg  tccgcttgg  tcatcttgg  cgccatctc  900
gtgtacgat  tcgtggctg  gctgtgccc  aaagggcca  tgaggatgc  ggtggaaac  960
gcccaggaa  gaaacgagc  catatttcc  gccctcata  actcatctg  catggtgtg  1020
acggtaggc  tggcgaagc  ggacccctc  tctcaggga  cactgcagc  cccttacga  1080
ccagagatg  aagaagact  ctatgacag  tttggggaa  cctcatacc  tgaagcctt  1140
gaagctccc  agcctggct  cccagggga  gagccggag  aggaggagg  aaggggtgt  1200
aagcttggt  tgggagact  catcttcta  agcgttctg  tgggcaagg  agcagccac  1260
ggcaacgga  actggagca  gacgctggc  tgctttatc  ccatcctca  tggcttgtg  1320
ctcaccctc  tgctgctcg  cgtgttcaa  aaggccctg  ccgccctcc  catctccat  1380
accttcggg  tcatctttt  cttctccac  gacaacctg  tgcgtcctt  catggacac  1440
ttggcctcc  accagctct  catctgaca  aagagctgc  gctctgaga  ctgtaggac  1500
cttcgccga  tgcaggtgt  tagttttac  ctctagtgc  atatatttt  ttttaaaaa  1560
acctttctt  ccttacaaa  gaaaaaaaa  gaataaaaa  gtgttgtgt  tacttcgtg  1620
cgaggaagc  gaagccgcc  ttctgtgct  gctgtcttg  caccagact  aggcttgcc  1680
gtcagagca  ctgtggcac  cgcaggtgg  atgctgggc  aacaagcct  tcttcaggg  1740
tgaggtcac  tgtgtggat  aggttggag  ggacgcagg  cccatccag  tctgtaatc  1800
atccttcag  gctgagcag  aggaacatg  gcgtcagtg  ggaccagga  gcacggtca  1860
gaaggacgc  aagcaccaa  accctgacc  gaggacaaa  gccagtttg  cgtcatgaa  1920
gcccccagt  ctttgtttg  gatgtctgt  acctttagt  tcttagaag  tgagtcctg  1980
tcttatttc  gcagtggac  gctgggaag  ggcttaatg  caataccaa  acatagatg  2040
ccctgctgg  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  2088



<210> 10235
<211> 448
<212> PRT
<213> Rattus norvegicus
<308> O88777
<400> 10235

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
  1               5                  10                  15
Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Ser Arg Ser Cys Gln 
             20                  25                  30
Asp Ser Arg Pro Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
         35                  40                  45
Ser Gln Glu Asn Glu Asp Asp Cys Glu Glu Asp Pro Asp His Tyr Ala 
     50                  55                  60
Cys Ser Gly Val Pro Gly Arg Pro Ser Gly Leu Glu Glu Glu Leu Thr 
 65                  70                  75                  80
Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                 85                  90                  95
Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
             100                105                110
Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
         115                120                125
Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
     130                135                140
Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
 145                150                155                160
Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                 165                170                175
Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Phe 
             180                185                190
Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Phe Leu Ala Val 
         195                200                205
Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
     210                215                220
Leu Val Leu Gln Gln Ala Tyr Leu Ile Val Ile Ser Ala Leu Met Ala 
 225                230                235                240
Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                 245                250                255
Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
             260                265                270
Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
         275                280                285
Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
     290                295                300
Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
 305                310                315                320
Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                 325                330                335
Pro Glu Ala Phe Glu Ala Pro Gln Pro Gly Tyr Pro Gly Glu Glu Pro 
             340                345                350
Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
         355                360                365
Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Asn Gly Asp 
     370                375                380
Trp Ser Thr Thr Leu Ala Cys Phe Ile Ala Ile Leu Ile Gly Leu Cys 
 385                390                395                400
Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                 405                410                415
Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
             420                425                430
Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
         435                440                445



<210> 10236
<211> 2236
<212> DNA
<213> Homo sapiens
<308> L43964
<400> 10236

cgagcggcg  cggagcagg  atttccagc  gtgaggaga  agccagaag  aagctattg  60
agctgaagg  acctgagac  gaagctagt  ccccctctg  attttactg  tgaagaaac  120
gaggccaca  agctaaagt  acttttccc  aggtcgccc  gcgaggacg  gggacttct  180
agacgtcag  agagtgatg  gagggagct  tgtgaccat  gaaagtgac  tgttaaaaa  240
cagcgctgc  ctctttgaa  gccagggag  atcattcat  tagcctgct  agaagaaga  300
accaagtgt  cgggattca  acctctctg  ggccccaag  gttcgtggt  cttccagag  360
cagggctat  ctcacattc  tggcctctg  cagcgagga  gaagtgtgt  atgagcgga  420
gtccctaat  tcggccgag  gccccacgc  gcgctcctg  caggagggc  ggcagggcc  480
agaggatgg  gagaacact  cccagtgga  aagccagga  aacgaggag  acggtgagg  540
ggaccctga  cgctatgtc  gtagtgggg  tcccgggcg  ccgccaggc  tggaggaag  600
gctgaccct  aaatacgga  cgaagcacg  gatcatgct  tttgtgcct  tcactctgt  660
catgatcgt  gtggtagcc  ccatcaagt  tgtgcgctt  tacacagag  agaatggac  720
gctcatcta  acgacattc  ctgaggaca  accctcggt  ggccagcgc  tcctcaact  780
cgtgctgaa  accctcatc  tgatcagcg  catcgtggt  atgaccatc  tcttggtgg  840
gctctacaa  taccgctgc  acaagttca  ccatggctg  ttgatcatg  cttcactga  900
gctgctgtt  ctcttcacc  atatctacc  tggggaagt  ctcaagacc  acaatgtgg  960
catggacta  cccaccctc  tgctgactg  ctggaactt  ggggcagtg  gcatggtgt  1020
catccactg  aagggccct  tggtgctgc  gcaggccta  ctcatcatg  tcagtgcgc  1080
catggccct  gtgttcatc  agtacctcc  agagtggtc  gcgtgggtc  tcctgggcg  1140
catctctgt  tatgatctc  tggctgtgc  gtgtcccaa  gggcctctg  gaatgctgg  1200
agaaactgc  caggagaga  atgagccca  attccctgc  ctgatatac  catctgcca  1260
ggtgtggac  gttggcatg  cgaagctgg  cccctcctc  cagggtgcc  tccagctcc  1320
ctacgaccc  gagatggaa  aagactcct  tgacagttt  ggggagcct  cataccccg  1380
agtctttga  cctcccttg  ctggctacc  aggggagga  ctggaggaa  aggaggaaa  1440
gggcgtgaa  cttggcctc  gggacttca  cttctacag  gtgctggtg  gcaaggcgg  1500
tgccacggg  agcggggac  ggaatacca  gctggcctg  ttcgtggcc  tcctcattg  1560
cttgtgtct  accctcctg  tgcttgctg  gttcaagaa  gcgctgccc  ccctcccca  1620
ctccatcac  ttcgggctc  tcttttact  ctccacgga  aacctggtg  ggccgttca  1680
ggacaccct  gcctcccat  agctctaca  ctgagggac  tggtgtgcc  caggctgca  1740
gctgcaggg  attttcatt  gatgcagtt  tatagtttt  cactctagt  ccatatatt  1800
ttaagactt  tctttcctt  aaaaataaa  tacgtgttt  cttggtgag  aggaggcag  1860
accagctct  tggtgccag  tgtttcatc  ccagacttt  gctcccgct  tggggagcg  1920
ctcgcttca  ggacaggaa  cacagcagg  ttatccaga  gaactgaga  ggtcagatt  1980
gggcgggga  aagagcatc  ggcatgagg  ctgagatgc  caaagagtg  gctcgggag  2040
ggcccctgg  acctgggtg  tctggctgg  gaggaaaag  cagttccct  cgaggagtg  2100
tcccaatgc  ttgtccatg  tgtccttgt  attttattg  ctttagaaa  tgagtcctg  2160
tcttgttac  gcagtcaca  tgctgggaa  tggcttaat  gtaatatca  taaatagat  2220
agtcctgtt  gaaaaa  2236



<210> 10237
<211> 448
<212> PRT
<213> Homo sapiens
<308> P49810
<400> 10237

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
  1               5                  10                  15
Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
             20                  25                  30
Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
         35                  40                  45
Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
     50                  55                  60
Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
 65                  70                  75                  80
Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                 85                  90                  95
Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
             100                105                110
Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
         115                120                125
Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
     130                135                140
Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
 145                150                155                160
Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                 165                170                175
Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
             180                185                190
Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
         195                200                205
Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
     210                215                220
Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
 225                230                235                240
Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                 245                250                255
Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
             260                265                270
Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
         275                280                285
Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
     290                295                300
Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
 305                310                315                320
Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                 325                330                335
Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
             340                345                350
Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
         355                360                365
Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
     370                375                380
Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys 
 385                390                395                400
Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                 405                410                415
Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
             420                425                430
Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
         435                440                445



<210> 10238
<211> 2088
<212> DNA
<213> Rattus norvegicus
<308> X99267
<400> 10238

ccggcggag  agctgtttc  ttaaggttg  gcctctgat  agctgggaa  ccagcagaa  60
gcaaaggtt  ctgttgatg  cttctcacc  gccctgggc  gtgaccgcc  gggagagac  120
atgctcaca  tcatggcca  tgatagcga  gaagaggtg  gcgatgagc  gacgtcctt  180
atgtcagcc  agagcccta  atcacgttc  tgccaggac  gcaggccag  cccagagga  240
ggagagaac  ctgcccagt  gaggagcca  gagaacgag  acgactgtg  ggaggaccc  300
gaccactat  cctgcagtg  ggttcctgg  cgaccatcg  gcctggagg  ggagctgac  360
ctcaagtat  gggcgaagc  cgtgatcat  ctgttcgtg  ctgtcacgc  gtgcatgat  420
gtggtggtg  ccaccatca  gtccgtgcg  ttctacacg  agaagaacg  gcagctcat  480
tacacgccc  tcaccgagg  cacaccctc  gtgggccag  ggctcctca  ctccgtgct  540
aacactctg  tcatgatca  cgtcattgt  gtcatgact  tcttcctag  ggtactcta  600
aaatatcgc  gttacaagt  catccatgg  tggctgatc  tgtcctccc  gatgctcct  660
ttcttgttc  cctacatct  cctcgggga  gtgttcaag  cctacaatg  ggccatgga  720
taccccaca  tgttcctgg  tgtctggaa  ttcggggca  tgggcatgg  gtgcatcca  780
tggaagggt  ccctggtgc  ccagcaggc  tacctcatt  tgatcagcg  actcatggc  840
ctggtgttc  tcaagtacc  gccggagtg  tccgcttgg  tcatcttgg  cgccatctc  900
gtgtacgat  tcgtggctg  gctgtgccc  aaagggcca  tgaggatgc  ggtggaaac  960
gcccaggaa  gaaacgagc  catatttcc  gccctcata  actcatctg  catggtgtg  1020
acggtaggc  tggcgaagc  ggacccctc  tctcaggga  cactgcagc  cccttacga  1080
ccagagatg  aagaagact  ctatgacag  tttggggaa  cctcatacc  tgaagcctt  1140
gaagctccc  agcctggct  cccagggga  gagccggag  aggaggagg  aaggggtgt  1200
aagcttggt  tgggagact  catcttcta  agcgttctg  tgggcaagg  agcagccac  1260
ggcaacgga  actggagca  gacgctggc  tgctttatc  ccatcctca  tggcttgtg  1320
ctcaccctc  tgctgctcg  cgtgttcaa  aaggccctg  ccgccctcc  catctccat  1380
accttcggg  tcatctttt  cttctccac  gacaacctg  tgcgtcctt  catggacac  1440
ttggcctcc  accagctct  catctgaca  aagagctgc  gctctgaga  ctgtaggac  1500
cttcgccga  tgcaggtgt  tagttttac  ctctagtgc  atatatttt  ttttaaaaa  1560
acctttctt  ccttacaaa  gaaaaaaaa  gaataaaaa  gtgttgtgt  tacttcgtg  1620
cgaggaagc  gaagccgcc  ttctgtgct  gctgtcttg  caccagact  aggcttgcc  1680
gtcagagca  ctgtggcac  cgcaggtgg  atgctgggc  aacaagcct  tcttcaggg  1740
tgaggtcac  tgtgtggat  aggttggag  ggacgcagg  cccatccag  tctgtaatc  1800
atccttcag  gctgagcag  aggaacatg  gcgtcagtg  ggaccagga  gcacggtca  1860
gaaggacgc  aagcaccaa  accctgacc  gaggacaaa  gccagtttg  cgtcatgaa  1920
gcccccagt  ctttgtttg  gatgtctgt  acctttagt  tcttagaag  tgagtcctg  1980
tcttatttc  gcagtggac  gctgggaag  ggcttaatg  caataccaa  acatagatg  2040
ccctgctgg  aaaaaaaaa  aaaaaaaaa  aaaaaaaaa  aaaaaaaa  2088



<210> 10239
<211> 448
<212> PRT
<213> Rattus norvegicus
<308> O88777
<400> 10239

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
  1               5                  10                  15
Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Ser Arg Ser Cys Gln 
             20                  25                  30
Asp Ser Arg Pro Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
         35                  40                  45
Ser Gln Glu Asn Glu Asp Asp Cys Glu Glu Asp Pro Asp His Tyr Ala 
     50                  55                  60
Cys Ser Gly Val Pro Gly Arg Pro Ser Gly Leu Glu Glu Glu Leu Thr 
 65                  70                  75                  80
Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                 85                  90                  95
Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
             100                105                110
Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
         115                120                125
Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
     130                135                140
Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
 145                150                155                160
Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                 165                170                175
Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Phe 
             180                185                190
Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Phe Leu Ala Val 
         195                200                205
Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
     210                215                220
Leu Val Leu Gln Gln Ala Tyr Leu Ile Val Ile Ser Ala Leu Met Ala 
 225                230                235                240
Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                 245                250                255
Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
             260                265                270
Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
         275                280                285
Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
     290                295                300
Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
 305                310                315                320
Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                 325                330                335
Pro Glu Ala Phe Glu Ala Pro Gln Pro Gly Tyr Pro Gly Glu Glu Pro 
             340                345                350
Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
         355                360                365
Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Asn Gly Asp 
     370                375                380
Trp Ser Thr Thr Leu Ala Cys Phe Ile Ala Ile Leu Ile Gly Leu Cys 
 385                390                395                400
Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                 405                410                415
Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
             420                425                430
Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
         435                440                445



<210> 10240
<211> 2236
<212> DNA
<213> Homo sapiens
<308> L43964
<400> 10240

cgagcggcg  cggagcagg  atttccagc  gtgaggaga  agccagaag  aagctattg  60
agctgaagg  acctgagac  gaagctagt  ccccctctg  attttactg  tgaagaaac  120
gaggccaca  agctaaagt  acttttccc  aggtcgccc  gcgaggacg  gggacttct  180
agacgtcag  agagtgatg  gagggagct  tgtgaccat  gaaagtgac  tgttaaaaa  240
cagcgctgc  ctctttgaa  gccagggag  atcattcat  tagcctgct  agaagaaga  300
accaagtgt  cgggattca  acctctctg  ggccccaag  gttcgtggt  cttccagag  360
cagggctat  ctcacattc  tggcctctg  cagcgagga  gaagtgtgt  atgagcgga  420
gtccctaat  tcggccgag  gccccacgc  gcgctcctg  caggagggc  ggcagggcc  480
agaggatgg  gagaacact  cccagtgga  aagccagga  aacgaggag  acggtgagg  540
ggaccctga  cgctatgtc  gtagtgggg  tcccgggcg  ccgccaggc  tggaggaag  600
gctgaccct  aaatacgga  cgaagcacg  gatcatgct  tttgtgcct  tcactctgt  660
catgatcgt  gtggtagcc  ccatcaagt  tgtgcgctt  tacacagag  agaatggac  720
gctcatcta  acgacattc  ctgaggaca  accctcggt  ggccagcgc  tcctcaact  780
cgtgctgaa  accctcatc  tgatcagcg  catcgtggt  atgaccatc  tcttggtgg  840
gctctacaa  taccgctgc  acaagttca  ccatggctg  ttgatcatg  cttcactga  900
gctgctgtt  ctcttcacc  atatctacc  tggggaagt  ctcaagacc  acaatgtgg  960
catggacta  cccaccctc  tgctgactg  ctggaactt  ggggcagtg  gcatggtgt  1020
catccactg  aagggccct  tggtgctgc  gcaggccta  ctcatcatg  tcagtgcgc  1080
catggccct  gtgttcatc  agtacctcc  agagtggtc  gcgtgggtc  tcctgggcg  1140
catctctgt  tatgatctc  tggctgtgc  gtgtcccaa  gggcctctg  gaatgctgg  1200
agaaactgc  caggagaga  atgagccca  attccctgc  ctgatatac  catctgcca  1260
ggtgtggac  gttggcatg  cgaagctgg  cccctcctc  cagggtgcc  tccagctcc  1320
ctacgaccc  gagatggaa  aagactcct  tgacagttt  ggggagcct  cataccccg  1380
agtctttga  cctcccttg  ctggctacc  aggggagga  ctggaggaa  aggaggaaa  1440
gggcgtgaa  cttggcctc  gggacttca  cttctacag  gtgctggtg  gcaaggcgg  1500
tgccacggg  agcggggac  ggaatacca  gctggcctg  ttcgtggcc  tcctcattg  1560
cttgtgtct  accctcctg  tgcttgctg  gttcaagaa  gcgctgccc  ccctcccca  1620
ctccatcac  ttcgggctc  tcttttact  ctccacgga  aacctggtg  ggccgttca  1680
ggacaccct  gcctcccat  agctctaca  ctgagggac  tggtgtgcc  caggctgca  1740
gctgcaggg  attttcatt  gatgcagtt  tatagtttt  cactctagt  ccatatatt  1800
ttaagactt  tctttcctt  aaaaataaa  tacgtgttt  cttggtgag  aggaggcag  1860
accagctct  tggtgccag  tgtttcatc  ccagacttt  gctcccgct  tggggagcg  1920
ctcgcttca  ggacaggaa  cacagcagg  ttatccaga  gaactgaga  ggtcagatt  1980
gggcgggga  aagagcatc  ggcatgagg  ctgagatgc  caaagagtg  gctcgggag  2040
ggcccctgg  acctgggtg  tctggctgg  gaggaaaag  cagttccct  cgaggagtg  2100
tcccaatgc  ttgtccatg  tgtccttgt  attttattg  ctttagaaa  tgagtcctg  2160
tcttgttac  gcagtcaca  tgctgggaa  tggcttaat  gtaatatca  taaatagat  2220
agtcctgtt  gaaaaa  2236



<210> 10241
<211> 448
<212> PRT
<213> Homo sapiens
<308> P49810
<400> 10241

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
  1               5                  10                  15
Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
             20                  25                  30
Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
         35                  40                  45
Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
     50                  55                  60
Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
 65                  70                  75                  80
Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                 85                  90                  95
Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
             100                105                110
Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
         115                120                125
Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
     130                135                140
Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
 145                150                155                160
Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                 165                170                175
Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
             180                185                190
Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
         195                200                205
Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
     210                215                220
Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
 225                230                235                240
Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                 245                250                255
Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
             260                265                270
Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
         275                280                285
Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
     290                295                300
Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
 305                310                315                320
Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                 325                330                335
Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
             340                345                350
Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
         355                360                365
Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
     370                375                380
Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys 
 385                390                395                400
Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                 405                410                415
Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
             420                425                430
Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
         435                440                445



<210> 10242
<211> 2031
<212> DNA
<213> Rattus norvegicus
<308> X99337
<400> 10242

gatgcttgg  naagtcctc  tctccctca  ccccacagg  tcagacgca  aggagaagg  60
gcatggaag  gtagaacct  aagacacaa  ccctaaatg  ggggagtct  cccttccgt  120
ccacctcag  gggaaggac  gttttccct  tgtgagcct  cccattcgc  gctcgctct  180
cggctaggg  ggatgtcgg  ctcgtcgct  cccggcgcc  tggccctct  gctcttgct  240
gtctctggc  cgctcctcc  agggccagg  gctgctcag  acgaaccaa  aattgtcac  300
agcgaagag  tcattattc  agacagcct  cttcctgtc  ccctgcagt  taacctcac  360
tccagctct  acaccctta  gtacagcta  tggacaaag  atggggtag  actcactgc  420
acccgtaag  atgccagca  catggaata  aggatcaat  agccaagag  tgaggattc  480
ggcgaatac  actgtgtat  tcattttgt  agcgctcct  aagcaaatg  caccattga  540
gtgaaagct  ctcctgaca  cactggcca  aaacgcagt  aaaacaaaa  tgaagggca  600
gatgctatg  tgtattgca  gtctgttgg  tacccccac  cggaatgga  gtggcgcaa  660
aaggagaat  gtgtgtttg  ggagatttc  aatagctct  gtcgcttct  catcatcaa  720
aaggagaat  acactgaat  gaatattgt  aatctccaa  tcacagaag  tcctggaga  780
tatgaatgt  atgccacca  ctccattgg  tctgcctcc  tttccacag  cctcagggt  840
cggagccac  ttgccccac  ttggccttt  ttgggaatt  tggctgaaa  catcatcct  900
gtggtgatc  ttgttgtgt  tgagaagag  aagaggcca  atgaggttc  tgatgatga  960
gaaccagcc  ggccaatga  aaccaactc  accaacaat  acaaagata  aaacttgcg  1020
cagagaaac  caaattaag  actgctttt  atctcttta  gttcctgaa  aatgatggc  1080
acatgacct  ctaagtttt  tgcttggac  tctttggtc  ctccctttc  agtgagcaa  1140
accacaatg  ccgtctaaa  catgcctta  ttagcctct  ctataaggg  gacctagcc  1200
ggtacattt  aaacaatgc  tcagtgtag  aggtgtaaa  tattttggg  cttgatgtg  1260
tgtgaatgt  gctttccct  cctttgtta  aatatttaa  tagaagcga  aggtccttt  1320
aggatcaga  catgcatgc  ccatttttt  acttataca  ctgttaaat  ggcaaagct  1380
taaatgcac  gctgccatc  agtgatcat  ttgnaaagt  cagcaaaac  tacagatat  1440
tacagtata  aaatatata  atattcata  cncnggggg  gggagaaat  caaaataaa  1500
tcaaagctt  tttcatttt  aagctgctg  tactcattc  ttattattt  ttgtcagat  1560
aggaagctg  agttctggt  caaaaagat  agagtataa  cttaagtct  tcattctaa  1620
ggcttactt  ccctataac  ttaagaacc  ggaacagtc  actgaacgg  tagaatgaa  1680
tgcagtata  atgtatgat  gctttttaa  tgactattt  tccttttgt  aaatcatgt  1740
aattctgaa  tcttttgca  tgatgtgtc  aaccttatt  ttgtatatt  aatcaaggc  1800
acttttata  tttcccatt  gttttcaat  accctgaaa  gttaatagc  tggtgatat  1860
ctatgcaac  ctagttata  cttttggtt  gacactgta  tttcacatt  atttcatga  1920
tgatgatag  ttttataac  tgactgggt  ctcatgcgg  actaactgt  gatgcatgt  1980
cttgtgttc  gtgtaatta  tgaagtgca  tggtgtaca  aaaaagtga  t  2031



<210> 10243
<211> 272
<212> PRT
<213> Rattus norvegicus
<308> P26453
<400> 10243

Met Ala Ala Ala Leu Leu Leu Ala Leu Ala Phe Thr Phe Leu Ser Gly 
  1               5                  10                  15
Gln Gly Ala Cys Ala Ala Ala Gly Thr Ile Val Thr Ser Val Gln Glu 
             20                  25                  30
Val Asp Ser Lys Thr Gln Leu Thr Cys Phe Leu Asn Ser Ser Gly Ile 
         35                  40                  45
Asp Ile Val Gly His Arg Trp Met Arg Gly Gly Lys Val Leu Gln Glu 
     50                  55                  60
Asp Thr Leu Pro Asp Leu Gln Met Lys Tyr Thr Val Asp Ala Asp Asp 
 65                  70                  75                  80
Arg Ser Gly Glu Tyr Ser Cys Ile Phe Leu Pro Glu Pro Val Gly Arg 
                 85                  90                  95
Gly Asn Ile Asn Val Glu Gly Pro Pro Arg Ile Lys Val Gly Lys Lys 
             100                105                110
Ser Glu His Ala Ser Glu Gly Glu Phe Val Lys Leu Ile Cys Lys Ser 
         115                120                125
Glu Ala Ser His Pro Pro Val Asp Glu Trp Val Trp Phe Lys Thr Ser 
     130                135                140
Asp Thr Gly Asp Gln Thr Ile Ser Asn Gly Thr Glu Ala Asn Ser Lys 
 145                150                155                160
Tyr Val Ile Ile Ser Thr Pro Glu Leu Ser Glu Leu Ile Ile Ser Asp 
                 165                170                175
Leu Asp Met Asn Val Asp Pro Gly Thr Tyr Val Cys Asn Ala Thr Asn 
             180                185                190
Ser Gln Gly Ser Ala Arg Glu Thr Ile Ser Leu Arg Val Arg Ser Arg 
         195                200                205
Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val 
     210                215                220
Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Asp Gln 
 225                230                235                240
Thr Leu Asp Glu Asp Asp Pro Gly Ala Ala Pro Leu Lys Gly Ser Gly 
                 245                250                255
Ser His Leu Asn Asp Lys Asp Lys Asn Val Arg Gln Arg Asn Ala Thr 
             260                265                270



<210> 10244
<211> 1646
<212> DNA
<213> Homo sapiens
<308> AF035287
<400> 10244

actggacaa  gaatggggt  gaactgagt  ccactcgta  gaatgccag  aacatggag  60
acaggatca  taagccgag  gctgaggat  caggcgaat  ccactgcgt  tatcacttt  120
tcagcgctc  taaagcaaa  gccaccatt  aagtgaaag  cgctcctga  atcactggc  180
ataaacgga  tgagaacaa  aatgaaggg  aggatgcca  tatgtattg  aagtcagtt  240
gctaccccc  cccagactg  atatggcgc  agaaggaga  cgggatgcc  atggacatt  300
tcaatacct  tggccgctt  ttcatcatc  acaaggaaa  ttacactga  ttgaacatt  360
tgaacctgc  gatcacgga  gaccctggc  agtatgaat  taatgccac  tggccccac  420
ctggccttt  ttgggaatt  tggctgaaa  tatcatcct  gtggtgatc  ttgttgtgt  480
tgagaagag  aagaggcca  atgaggttc  tgacgctgg  ccaatgaaa  ccaactcta  540
caacaatca  aaagataaa  acttgcgcc  gagaaacac  aattaagta  tgcttacaa  600
atctttagg  tcctgaaac  ggtggcaac  tgacctgct  aaattttct  cttggacct  660
tttggttct  tcccctttc  agtgagcaa  accacaatg  ctgtctaaa  catgcctta  720
ttagcctct  ctgtaaggg  gatctagcc  ggtacattt  aaacaatgc  tcagtgtag  780
aggtgtaaa  tattttggg  ttgatgtgc  gtgaatgtt  ctttttttt  tcctttgtt  840
aaatattta  atagaagtg  aaaggtcct  tgaggatca  atcatgcat  cgccatttt  900
tacttaatg  agctgttaa  ttggcaaag  tctaaaatg  actgctgcc  tctagtgat  960
cacttttgt  aagtacagc  aaacctaca  atatataca  tatataaat  tatatatat  1020
tatatttat  tttttgggg  tgggagaaa  ccaaaataa  gtaaatgct  gtttcattt  1080
taagctgct  atattcatt  cttattgta  gttgtcaga  gaggaaatt  tgcagttct  1140
gtacataaa  atgagtaat  taaactgaa  tctataatt  taagggctt  acctgtgac  1200
ttaataagc  ggaacagtc  actgaatgg  tataatgaa  tgcagtata  acgtatgat  1260
gctttttaa  tgattatct  ttcttctgt  aagtcatgt  aattcataa  tccttttgc  1320
ctgatgtgt  gaaccttat  cttgtacat  cattcaatc  aggcaaact  ttataattt  1380
tcttttgtt  ccaatgacc  tgaaatgtt  tagcatggt  atattctat  caactatag  1440
tatactttt  ggtttgaca  tgtattttt  cacattgat  tactggttg  tgatagatt  1500
tataaccta  cggttctca  gcggtgcgt  attgtagat  catgtactt  tgtgttttg  1560
gtaattatt  aagtgcaat  atgtataaa  aagtggatt  acctgtttt  aaaaataaa  1620
cattgataa  aaaaaaaaa  aaaaaa  1646



<210> 10245
<211> 2031
<212> DNA
<213> Rattus norvegicus
<308> X99337
<400> 10245

gatgcttgg  naagtcctc  tctccctca  ccccacagg  tcagacgca  aggagaagg  60
gcatggaag  gtagaacct  aagacacaa  ccctaaatg  ggggagtct  cccttccgt  120
ccacctcag  gggaaggac  gttttccct  tgtgagcct  cccattcgc  gctcgctct  180
cggctaggg  ggatgtcgg  ctcgtcgct  cccggcgcc  tggccctct  gctcttgct  240
gtctctggc  cgctcctcc  agggccagg  gctgctcag  acgaaccaa  aattgtcac  300
agcgaagag  tcattattc  agacagcct  cttcctgtc  ccctgcagt  taacctcac  360
tccagctct  acaccctta  gtacagcta  tggacaaag  atggggtag  actcactgc  420
acccgtaag  atgccagca  catggaata  aggatcaat  agccaagag  tgaggattc  480
ggcgaatac  actgtgtat  tcattttgt  agcgctcct  aagcaaatg  caccattga  540
gtgaaagct  ctcctgaca  cactggcca  aaacgcagt  aaaacaaaa  tgaagggca  600
gatgctatg  tgtattgca  gtctgttgg  tacccccac  cggaatgga  gtggcgcaa  660
aaggagaat  gtgtgtttg  ggagatttc  aatagctct  gtcgcttct  catcatcaa  720
aaggagaat  acactgaat  gaatattgt  aatctccaa  tcacagaag  tcctggaga  780
tatgaatgt  atgccacca  ctccattgg  tctgcctcc  tttccacag  cctcagggt  840
cggagccac  ttgccccac  ttggccttt  ttgggaatt  tggctgaaa  catcatcct  900
gtggtgatc  ttgttgtgt  tgagaagag  aagaggcca  atgaggttc  tgatgatga  960
gaaccagcc  ggccaatga  aaccaactc  accaacaat  acaaagata  aaacttgcg  1020
cagagaaac  caaattaag  actgctttt  atctcttta  gttcctgaa  aatgatggc  1080
acatgacct  ctaagtttt  tgcttggac  tctttggtc  ctccctttc  agtgagcaa  1140
accacaatg  ccgtctaaa  catgcctta  ttagcctct  ctataaggg  gacctagcc  1200
ggtacattt  aaacaatgc  tcagtgtag  aggtgtaaa  tattttggg  cttgatgtg  1260
tgtgaatgt  gctttccct  cctttgtta  aatatttaa  tagaagcga  aggtccttt  1320
aggatcaga  catgcatgc  ccatttttt  acttataca  ctgttaaat  ggcaaagct  1380
taaatgcac  gctgccatc  agtgatcat  ttgnaaagt  cagcaaaac  tacagatat  1440
tacagtata  aaatatata  atattcata  cncnggggg  gggagaaat  caaaataaa  1500
tcaaagctt  tttcatttt  aagctgctg  tactcattc  ttattattt  ttgtcagat  1560
aggaagctg  agttctggt  caaaaagat  agagtataa  cttaagtct  tcattctaa  1620
ggcttactt  ccctataac  ttaagaacc  ggaacagtc  actgaacgg  tagaatgaa  1680
tgcagtata  atgtatgat  gctttttaa  tgactattt  tccttttgt  aaatcatgt  1740
aattctgaa  tcttttgca  tgatgtgtc  aaccttatt  ttgtatatt  aatcaaggc  1800
acttttata  tttcccatt  gttttcaat  accctgaaa  gttaatagc  tggtgatat  1860
ctatgcaac  ctagttata  cttttggtt  gacactgta  tttcacatt  atttcatga  1920
tgatgatag  ttttataac  tgactgggt  ctcatgcgg  actaactgt  gatgcatgt  1980
cttgtgttc  gtgtaatta  tgaagtgca  tggtgtaca  aaaaagtga  t  2031



<210> 10246
<211> 281
<212> PRT
<213> Rattus norvegicus
<308> CAA67711
<400> 10246

Met Ser Gly Ser Ser Leu Pro Gly Ala Leu Ala Leu Ser Leu Leu Leu 
  1               5                  10                  15
Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Glu Pro 
             20                  25                  30
Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp Ser Leu Leu Pro 
         35                  40                  45
Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser His Thr Leu Met Tyr 
     50                  55                  60
Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Thr Ala Thr Arg Lys Asn 
 65                  70                  75                  80
Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro Arg Ala Glu Asp Ser 
                 85                  90                  95
Gly Glu Tyr His Cys Val Tyr His Phe Val Ser Ala Pro Lys Ala Asn 
             100                105                110
Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile Thr Gly His Lys Arg 
         115                120                125
Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Met Met Tyr Cys Lys Ser 
     130                135                140
Val Gly Tyr Pro His Pro Glu Trp Met Trp Arg Lys Lys Glu Asn Gly 
 145                150                155                160
Val Phe Glu Glu Ile Ser Asn Ser Ser Gly Arg Phe Phe Ile Ile Asn 
                 165                170                175
Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn Leu Gln Ile Thr Glu 
             180                185                190
Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn Ser Ile Gly Ser Ala 
         195                200                205
Ser Val Ser Thr Val Leu Arg Val Arg Ser His Leu Ala Pro Leu Trp 
     210                215                220
Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile Leu Val Val Ile Ile 
 225                230                235                240
Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu Val Pro Asp Asp Asp 
                 245                250                255
Glu Pro Ala Gly Pro Met Lys Thr Asn Ser Thr Asn Asn His Lys Asp 
             260                265                270
Lys Asn Leu Arg Gln Arg Asn Thr Asn 
         275                280



<210> 10247
<211> 1646
<212> DNA
<213> Homo sapiens
<308> AF035287
<400> 10247

actggacaa  gaatggggt  gaactgagt  ccactcgta  gaatgccag  aacatggag  60
acaggatca  taagccgag  gctgaggat  caggcgaat  ccactgcgt  tatcacttt  120
tcagcgctc  taaagcaaa  gccaccatt  aagtgaaag  cgctcctga  atcactggc  180
ataaacgga  tgagaacaa  aatgaaggg  aggatgcca  tatgtattg  aagtcagtt  240
gctaccccc  cccagactg  atatggcgc  agaaggaga  cgggatgcc  atggacatt  300
tcaatacct  tggccgctt  ttcatcatc  acaaggaaa  ttacactga  ttgaacatt  360
tgaacctgc  gatcacgga  gaccctggc  agtatgaat  taatgccac  tggccccac  420
ctggccttt  ttgggaatt  tggctgaaa  tatcatcct  gtggtgatc  ttgttgtgt  480
tgagaagag  aagaggcca  atgaggttc  tgacgctgg  ccaatgaaa  ccaactcta  540
caacaatca  aaagataaa  acttgcgcc  gagaaacac  aattaagta  tgcttacaa  600
atctttagg  tcctgaaac  ggtggcaac  tgacctgct  aaattttct  cttggacct  660
tttggttct  tcccctttc  agtgagcaa  accacaatg  ctgtctaaa  catgcctta  720
ttagcctct  ctgtaaggg  gatctagcc  ggtacattt  aaacaatgc  tcagtgtag  780
aggtgtaaa  tattttggg  ttgatgtgc  gtgaatgtt  ctttttttt  tcctttgtt  840
aaatattta  atagaagtg  aaaggtcct  tgaggatca  atcatgcat  cgccatttt  900
tacttaatg  agctgttaa  ttggcaaag  tctaaaatg  actgctgcc  tctagtgat  960
cacttttgt  aagtacagc  aaacctaca  atatataca  tatataaat  tatatatat  1020
tatatttat  tttttgggg  tgggagaaa  ccaaaataa  gtaaatgct  gtttcattt  1080
taagctgct  atattcatt  cttattgta  gttgtcaga  gaggaaatt  tgcagttct  1140
gtacataaa  atgagtaat  taaactgaa  tctataatt  taagggctt  acctgtgac  1200
ttaataagc  ggaacagtc  actgaatgg  tataatgaa  tgcagtata  acgtatgat  1260
gctttttaa  tgattatct  ttcttctgt  aagtcatgt  aattcataa  tccttttgc  1320
ctgatgtgt  gaaccttat  cttgtacat  cattcaatc  aggcaaact  ttataattt  1380
tcttttgtt  ccaatgacc  tgaaatgtt  tagcatggt  atattctat  caactatag  1440
tatactttt  ggtttgaca  tgtattttt  cacattgat  tactggttg  tgatagatt  1500
tataaccta  cggttctca  gcggtgcgt  attgtagat  catgtactt  tgtgttttg  1560
gtaattatt  aagtgcaat  atgtataaa  aagtggatt  acctgtttt  aaaaataaa  1620
cattgataa  aaaaaaaaa  aaaaaa  1646



<210> 10248
<211> 398
<212> PRT
<213> Homo sapiens
<308> NP_036560
<400> 10248

Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu 
  1               5                  10                  15
Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Ala Gly 
             20                  25                  30
Phe Val Lys Ser Pro Met Ser Glu Thr Lys Leu Thr Gly Asp Ala Phe 
         35                  40                  45
Glu Leu Tyr Cys Asp Val Val Gly Ser Pro Thr Pro Glu Ile Gln Trp 
     50                  55                  60
Trp Tyr Ala Glu Val Asn Arg Ala Glu Ser Phe Arg Gln Leu Trp Asp 
 65                  70                  75                  80
Gly Ala Arg Lys Arg Arg Val Thr Val Asn Thr Ala Tyr Gly Ser Asn 
                 85                  90                  95
Gly Val Ser Val Leu Arg Ile Thr Arg Leu Thr Leu Glu Asp Ser Gly 
             100                105                110
Thr Tyr Glu Cys Arg Ala Ser Asn Asp Pro Lys Arg Asn Asp Leu Arg 
         115                120                125
Gln Asn Pro Ser Ile Thr Trp Ile Arg Ala Gln Ala Thr Ile Ser Val 
     130                135                140
Leu Gln Lys Pro Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp 
 145                150                155                160
Ser Pro Val Leu Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser 
                 165                170                175
His Thr Leu Thr Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Ser 
             180                185                190
Ala Thr Arg Lys Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro 
         195                200                205
Arg Ala Glu Asp Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser 
     210                215                220
Ala Pro Lys Ala Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile 
 225                230                235                240
Thr Gly His Lys Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Thr 
                 245                250                255
Met Tyr Cys Lys Ser Val Gly Tyr Pro His Pro Asp Trp Ile Trp Arg 
             260                265                270
Lys Lys Glu Asn Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg 
         275                280                285
Phe Phe Ile Ile Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn 
     290                295                300
Leu Gln Ile Thr Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn 
 305                310                315                320
Ala Ile Gly Ser Ala Ser Val Val Thr Val Leu Arg Val Arg Ser His 
                 325                330                335
Leu Ala Pro Leu Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile 
             340                345                350
Leu Val Val Ile Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu 
         355                360                365
Val Pro Asp Asp Asp Glu Pro Ala Gly Pro Met Lys Thr Asn Ser Thr 
     370                375                380
Asn Asn His Lys Asp Lys Asn Leu Arg Gln Arg Asn Thr Asn 
 385                390                395



<210> 10249
<211> 2369
<212> DNA
<213> Rattus norvegicus
<308> X99338
<400> 10249

gggacgggg  aaggacgga  ctcggccgc  gctgcctcc  tcgttcact  cctcgcgct  60
tcgcccgcc  cctccctcc  tcccctccc  tccccgggc  cgggcccgg  ccattcgct  120
ctcgctctc  ggctaggga  gatgtcggg  tcgtcgctc  ccggcgccc  ggccctctc  180
ctcttgctg  tctctggct  gctcctccc  gggccaggc  ctgctcaga  cgctgggtt  240
gtcaagtcg  ccatgtcag  aactaagct  acaggggac  cctttgagc  gtactgtga  300
gtggtcggg  gtcccacgc  agagatcca  tggtggtac  cagaagtca  ccgggcaga  360
tctttcaga  agctgtggg  cggtgctcg  aagcgccgt  tcaccgtaa  caccgccta  420
gggtcaaac  gcgtgagtg  gctgagaat  acccggctc  ccttggagg  ctctgggac  480
tacgagtgc  gggcaagca  cgaccccaa  cggaatgac  tgaggcaaa  cccttccat  540
acatggatt  gagcccagg  caccataag  gtccttcag  aaccaagaa  tgtcaccag  600
gaagaggtc  ttattcgag  cagcctcct  cctgtcacc  tgcagtgta  cctcacttc  660
agctctcac  cccttatgt  cagctactg  acaaagaat  gggtagaac  cactgccac  720
cgtaagaat  ccagcaaca  ggaatacag  atcaataag  caagagctg  ggattcagg  780
gaataccac  gtgtatatc  ttttgtcag  gctcctaaa  caaatgcca  cattgaagt  840
aaagctgct  ctgacatca  tggccataa  cgcagtgaa  acaaaaatg  agggcagga  900
gctatgatg  attgcaagt  tgttggcta  ccccacccg  aatggatgt  gcgcaagaa  960
gagaatggt  tgtttgagg  gatttccaa  agctctggt  gcttcttca  catcaacaa  1020
gagaattac  ctgaattga  tattgtgaa  ctccaaatc  cagaagatc  tggagagta  1080
gaatgtaat  ccaccaact  cattggctc  gcctccgtt  ccacagtcc  cagggtacg  1140
agccacctt  ccccacttt  gcctttctt  ggaattctg  ctgaaatca  catccttgt  1200
gtgatcatt  ttgtgtatg  gaagaggaa  aggccagat  aggttcctg  tgccgggcc  1260
atgaaaacc  actctacca  caatcacaa  gataaaaac  tgcgccaga  aaacacaaa  1320
taagtactg  ttttaatct  tttaggttc  tgaaaaatg  tggcaacat  acctgctaa  1380
ttttctgct  ggacctctt  ggtctctcc  tttcaagtg  gcaacacca  aatgaccgt  1440
taaagcatg  cttatttag  ctctcctat  agggtgacc  agccaggta  attttaaac  1500
atgcttcag  gtagaaggt  taaactatt  tggggcttg  tgtgctgtg  atgttgctt  1560
ccctccctt  gttaaaata  ttaaataga  gcgaaaggt  ctttgagga  cagatcatg  1620
atgcgccat  tttttactt  tacagctgt  aaattggca  agctctaaa  gcactgctg  1680
catctagtg  tcattttgn  aagtacagc  aaacctaca  atatataca  tatataaat  1740
tatatatat  catatcncn  ggggtggga  aaatccaaa  taaagtcaa  gcttgtttc  1800
tttttaagc  gctgatact  attccttat  atttgttgt  agatgagga  gctgcagtt  1860
tggtacaaa  agatgagag  ataaactta  gtctgtcat  ctaagggct  acttaccct  1920
taactttaa  aacctggaa  agtccactg  acggctaga  tgaattgca  tatatatgt  1980
tgattgctt  ttaagtgac  atttttcct  ttgtcaaat  atgtaaatt  tgaaatctt  2040
tgcactgat  tgtcgaacc  tattcttgt  tattcaatc  aggcaactt  tataatttc  2100
catttgttt  caatgaccc  gaaatgtta  tagcatggt  atattctat  caactctag  2160
tataccttt  ggtttgaca  tgtattttc  cattgattt  atgactgat  atagatttt  2220
taacctgac  gggttctca  gcggtacta  ctgtagatg  atgtacttg  gttctgtgt  2280
attattgaa  tgcaatggt  tacaaaaaa  gtgaattca  ctgttttta  caataaaac  2340
ttgataaaa  aaaaaaaaa  aaaaaaaaa  2369



<210> 10250
<211> 393
<212> PRT
<213> Rattus norvegicus
<308> CAA67712
<400> 10250

Met Ser Gly Ser Ser Leu Pro Gly Ala Leu Ala Leu Ser Leu Leu Leu 
  1               5                  10                  15
Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Ala Gly 
             20                  25                  30
Phe Val Lys Ser Pro Met Ser Glu Thr Lys Leu Thr Gly Asp Ala Phe 
         35                  40                  45
Glu Leu Tyr Cys Asp Val Val Gly Ser Pro Thr Pro Glu Ile Gln Trp 
     50                  55                  60
Trp Tyr Ala Glu Val Asn Arg Ala Glu Ser Phe Arg Gln Leu Trp Asp 
 65                  70                  75                  80
Gly Ala Arg Lys Arg Arg Val Thr Val Asn Thr Ala Tyr Gly Ser Asn 
                 85                  90                  95
Gly Val Ser Val Leu Arg Ile Thr Arg Leu Thr Leu Glu Asp Ser Gly 
             100                105                110
Thr Tyr Glu Cys Arg Ala Ser Asn Asp Pro Lys Arg Asn Asp Leu Arg 
         115                120                125
Gln Asn Pro Ser Ile Thr Trp Ile Arg Ala Gln Ala Thr Ile Ser Val 
     130                135                140
Leu Gln Lys Pro Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp 
 145                150                155                160
Ser Leu Leu Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser His 
                 165                170                175
Thr Leu Met Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Thr Ala 
             180                185                190
Thr Arg Lys Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro Arg 
         195                200                205
Ala Glu Asp Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser Ala 
     210                215                220
Pro Lys Ala Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile Thr 
 225                230                235                240
Gly His Lys Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Met Met 
                 245                250                255
Tyr Cys Lys Ser Val Gly Tyr Pro His Pro Glu Trp Met Trp Arg Lys 
             260                265                270
Lys Glu Asn Gly Val Phe Glu Glu Ile Ser Asn Ser Ser Gly Arg Phe 
         275                280                285
Phe Ile Ile Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn Leu 
     290                295                300
Gln Ile Thr Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn Ser 
 305                310                315                320
Ile Gly Ser Ala Ser Val Ser Thr Val Leu Arg Val Arg Ser His Leu 
                 325                330                335
Ala Pro Leu Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile Leu 
             340                345                350
Val Val Ile Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu Val 
         355                360                365
Pro Asp Ala Gly Pro Met Lys Thr Asn Ser Thr Asn Asn His Lys Asp 
     370                375                380
Lys Asn Leu Arg Gln Arg Asn Thr Asn 
 385                390



<210> 10251
<211> 1646
<212> DNA
<213> Homo sapiens
<308> AF035287
<400> 10251

actggacaa  gaatggggt  gaactgagt  ccactcgta  gaatgccag  aacatggag  60
acaggatca  taagccgag  gctgaggat  caggcgaat  ccactgcgt  tatcacttt  120
tcagcgctc  taaagcaaa  gccaccatt  aagtgaaag  cgctcctga  atcactggc  180
ataaacgga  tgagaacaa  aatgaaggg  aggatgcca  tatgtattg  aagtcagtt  240
gctaccccc  cccagactg  atatggcgc  agaaggaga  cgggatgcc  atggacatt  300
tcaatacct  tggccgctt  ttcatcatc  acaaggaaa  ttacactga  ttgaacatt  360
tgaacctgc  gatcacgga  gaccctggc  agtatgaat  taatgccac  tggccccac  420
ctggccttt  ttgggaatt  tggctgaaa  tatcatcct  gtggtgatc  ttgttgtgt  480
tgagaagag  aagaggcca  atgaggttc  tgacgctgg  ccaatgaaa  ccaactcta  540
caacaatca  aaagataaa  acttgcgcc  gagaaacac  aattaagta  tgcttacaa  600
atctttagg  tcctgaaac  ggtggcaac  tgacctgct  aaattttct  cttggacct  660
tttggttct  tcccctttc  agtgagcaa  accacaatg  ctgtctaaa  catgcctta  720
ttagcctct  ctgtaaggg  gatctagcc  ggtacattt  aaacaatgc  tcagtgtag  780
aggtgtaaa  tattttggg  ttgatgtgc  gtgaatgtt  ctttttttt  tcctttgtt  840
aaatattta  atagaagtg  aaaggtcct  tgaggatca  atcatgcat  cgccatttt  900
tacttaatg  agctgttaa  ttggcaaag  tctaaaatg  actgctgcc  tctagtgat  960
cacttttgt  aagtacagc  aaacctaca  atatataca  tatataaat  tatatatat  1020
tatatttat  tttttgggg  tgggagaaa  ccaaaataa  gtaaatgct  gtttcattt  1080
taagctgct  atattcatt  cttattgta  gttgtcaga  gaggaaatt  tgcagttct  1140
gtacataaa  atgagtaat  taaactgaa  tctataatt  taagggctt  acctgtgac  1200
ttaataagc  ggaacagtc  actgaatgg  tataatgaa  tgcagtata  acgtatgat  1260
gctttttaa  tgattatct  ttcttctgt  aagtcatgt  aattcataa  tccttttgc  1320
ctgatgtgt  gaaccttat  cttgtacat  cattcaatc  aggcaaact  ttataattt  1380
tcttttgtt  ccaatgacc  tgaaatgtt  tagcatggt  atattctat  caactatag  1440
tatactttt  ggtttgaca  tgtattttt  cacattgat  tactggttg  tgatagatt  1500
tataaccta  cggttctca  gcggtgcgt  attgtagat  catgtactt  tgtgttttg  1560
gtaattatt  aagtgcaat  atgtataaa  aagtggatt  acctgtttt  aaaaataaa  1620
cattgataa  aaaaaaaaa  aaaaaa  1646



<210> 10252
<211> 398
<212> PRT
<213> Homo sapiens
<308> NP_036560
<400> 10252

Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu 
  1               5                  10                  15
Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Ala Gly 
             20                  25                  30
Phe Val Lys Ser Pro Met Ser Glu Thr Lys Leu Thr Gly Asp Ala Phe 
         35                  40                  45
Glu Leu Tyr Cys Asp Val Val Gly Ser Pro Thr Pro Glu Ile Gln Trp 
     50                  55                  60
Trp Tyr Ala Glu Val Asn Arg Ala Glu Ser Phe Arg Gln Leu Trp Asp 
 65                  70                  75                  80
Gly Ala Arg Lys Arg Arg Val Thr Val Asn Thr Ala Tyr Gly Ser Asn 
                 85                  90                  95
Gly Val Ser Val Leu Arg Ile Thr Arg Leu Thr Leu Glu Asp Ser Gly 
             100                105                110
Thr Tyr Glu Cys Arg Ala Ser Asn Asp Pro Lys Arg Asn Asp Leu Arg 
         115                120                125
Gln Asn Pro Ser Ile Thr Trp Ile Arg Ala Gln Ala Thr Ile Ser Val 
     130                135                140
Leu Gln Lys Pro Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp 
 145                150                155                160
Ser Pro Val Leu Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser 
                 165                170                175
His Thr Leu Thr Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Ser 
             180                185                190
Ala Thr Arg Lys Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro 
         195                200                205
Arg Ala Glu Asp Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser 
     210                215                220
Ala Pro Lys Ala Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile 
 225                230                235                240
Thr Gly His Lys Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Thr 
                 245                250                255
Met Tyr Cys Lys Ser Val Gly Tyr Pro His Pro Asp Trp Ile Trp Arg 
             260                265                270
Lys Lys Glu Asn Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg 
         275                280                285
Phe Phe Ile Ile Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn 
     290                295                300
Leu Gln Ile Thr Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn 
 305                310                315                320
Ala Ile Gly Ser Ala Ser Val Val Thr Val Leu Arg Val Arg Ser His 
                 325                330                335
Leu Ala Pro Leu Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile 
             340                345                350
Leu Val Val Ile Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu 
         355                360                365
Val Pro Asp Asp Asp Glu Pro Ala Gly Pro Met Lys Thr Asn Ser Thr 
     370                375                380
Asn Asn His Lys Asp Lys Asn Leu Arg Gln Arg Asn Thr Asn 
 385                390                395



<210> 10253
<211> 2369
<212> DNA
<213> Rattus norvegicus
<308> X99338
<400> 10253

gggacgggg  aaggacgga  ctcggccgc  gctgcctcc  tcgttcact  cctcgcgct  60
tcgcccgcc  cctccctcc  tcccctccc  tccccgggc  cgggcccgg  ccattcgct  120
ctcgctctc  ggctaggga  gatgtcggg  tcgtcgctc  ccggcgccc  ggccctctc  180
ctcttgctg  tctctggct  gctcctccc  gggccaggc  ctgctcaga  cgctgggtt  240
gtcaagtcg  ccatgtcag  aactaagct  acaggggac  cctttgagc  gtactgtga  300
gtggtcggg  gtcccacgc  agagatcca  tggtggtac  cagaagtca  ccgggcaga  360
tctttcaga  agctgtggg  cggtgctcg  aagcgccgt  tcaccgtaa  caccgccta  420
gggtcaaac  gcgtgagtg  gctgagaat  acccggctc  ccttggagg  ctctgggac  480
tacgagtgc  gggcaagca  cgaccccaa  cggaatgac  tgaggcaaa  cccttccat  540
acatggatt  gagcccagg  caccataag  gtccttcag  aaccaagaa  tgtcaccag  600
gaagaggtc  ttattcgag  cagcctcct  cctgtcacc  tgcagtgta  cctcacttc  660
agctctcac  cccttatgt  cagctactg  acaaagaat  gggtagaac  cactgccac  720
cgtaagaat  ccagcaaca  ggaatacag  atcaataag  caagagctg  ggattcagg  780
gaataccac  gtgtatatc  ttttgtcag  gctcctaaa  caaatgcca  cattgaagt  840
aaagctgct  ctgacatca  tggccataa  cgcagtgaa  acaaaaatg  agggcagga  900
gctatgatg  attgcaagt  tgttggcta  ccccacccg  aatggatgt  gcgcaagaa  960
gagaatggt  tgtttgagg  gatttccaa  agctctggt  gcttcttca  catcaacaa  1020
gagaattac  ctgaattga  tattgtgaa  ctccaaatc  cagaagatc  tggagagta  1080
gaatgtaat  ccaccaact  cattggctc  gcctccgtt  ccacagtcc  cagggtacg  1140
agccacctt  ccccacttt  gcctttctt  ggaattctg  ctgaaatca  catccttgt  1200
gtgatcatt  ttgtgtatg  gaagaggaa  aggccagat  aggttcctg  tgccgggcc  1260
atgaaaacc  actctacca  caatcacaa  gataaaaac  tgcgccaga  aaacacaaa  1320
taagtactg  ttttaatct  tttaggttc  tgaaaaatg  tggcaacat  acctgctaa  1380
ttttctgct  ggacctctt  ggtctctcc  tttcaagtg  gcaacacca  aatgaccgt  1440
taaagcatg  cttatttag  ctctcctat  agggtgacc  agccaggta  attttaaac  1500
atgcttcag  gtagaaggt  taaactatt  tggggcttg  tgtgctgtg  atgttgctt  1560
ccctccctt  gttaaaata  ttaaataga  gcgaaaggt  ctttgagga  cagatcatg  1620
atgcgccat  tttttactt  tacagctgt  aaattggca  agctctaaa  gcactgctg  1680
catctagtg  tcattttgn  aagtacagc  aaacctaca  atatataca  tatataaat  1740
tatatatat  catatcncn  ggggtggga  aaatccaaa  taaagtcaa  gcttgtttc  1800
tttttaagc  gctgatact  attccttat  atttgttgt  agatgagga  gctgcagtt  1860
tggtacaaa  agatgagag  ataaactta  gtctgtcat  ctaagggct  acttaccct  1920
taactttaa  aacctggaa  agtccactg  acggctaga  tgaattgca  tatatatgt  1980
tgattgctt  ttaagtgac  atttttcct  ttgtcaaat  atgtaaatt  tgaaatctt  2040
tgcactgat  tgtcgaacc  tattcttgt  tattcaatc  aggcaactt  tataatttc  2100
catttgttt  caatgaccc  gaaatgtta  tagcatggt  atattctat  caactctag  2160
tataccttt  ggtttgaca  tgtattttc  cattgattt  atgactgat  atagatttt  2220
taacctgac  gggttctca  gcggtacta  ctgtagatg  atgtacttg  gttctgtgt  2280
attattgaa  tgcaatggt  tacaaaaaa  gtgaattca  ctgttttta  caataaaac  2340
ttgataaaa  aaaaaaaaa  aaaaaaaaa  2369



<210> 10254
<211> 393
<212> PRT
<213> Rattus norvegicus
<308> CAA67712
<400> 10254

Met Ser Gly Ser Ser Leu Pro Gly Ala Leu Ala Leu Ser Leu Leu Leu 
  1               5                  10                  15
Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Ala Gly 
             20                  25                  30
Phe Val Lys Ser Pro Met Ser Glu Thr Lys Leu Thr Gly Asp Ala Phe 
         35                  40                  45
Glu Leu Tyr Cys Asp Val Val Gly Ser Pro Thr Pro Glu Ile Gln Trp 
     50                  55                  60
Trp Tyr Ala Glu Val Asn Arg Ala Glu Ser Phe Arg Gln Leu Trp Asp 
 65                  70                  75                  80
Gly Ala Arg Lys Arg Arg Val Thr Val Asn Thr Ala Tyr Gly Ser Asn 
                 85                  90                  95
Gly Val Ser Val Leu Arg Ile Thr Arg Leu Thr Leu Glu Asp Ser Gly 
             100                105                110
Thr Tyr Glu Cys Arg Ala Ser Asn Asp Pro Lys Arg Asn Asp Leu Arg 
         115                120                125
Gln Asn Pro Ser Ile Thr Trp Ile Arg Ala Gln Ala Thr Ile Ser Val 
     130                135                140
Leu Gln Lys Pro Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp 
 145                150                155                160
Ser Leu Leu Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser His 
                 165                170                175
Thr Leu Met Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Thr Ala 
             180                185                190
Thr Arg Lys Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro Arg 
         195                200                205
Ala Glu Asp Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser Ala 
     210                215                220
Pro Lys Ala Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile Thr 
 225                230                235                240
Gly His Lys Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Met Met 
                 245                250                255
Tyr Cys Lys Ser Val Gly Tyr Pro His Pro Glu Trp Met Trp Arg Lys 
             260                265                270
Lys Glu Asn Gly Val Phe Glu Glu Ile Ser Asn Ser Ser Gly Arg Phe 
         275                280                285
Phe Ile Ile Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn Leu 
     290                295                300
Gln Ile Thr Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn Ser 
 305                310                315                320
Ile Gly Ser Ala Ser Val Ser Thr Val Leu Arg Val Arg Ser His Leu 
                 325                330                335
Ala Pro Leu Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile Leu 
             340                345                350
Val Val Ile Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu Val 
         355                360                365
Pro Asp Ala Gly Pro Met Lys Thr Asn Ser Thr Asn Asn His Lys Asp 
     370                375                380
Lys Asn Leu Arg Gln Arg Asn Thr Asn 
 385                390



<210> 10255
<211> 1646
<212> DNA
<213> Homo sapiens
<308> AF035287
<400> 10255

actggacaa  gaatggggt  gaactgagt  ccactcgta  gaatgccag  aacatggag  60
acaggatca  taagccgag  gctgaggat  caggcgaat  ccactgcgt  tatcacttt  120
tcagcgctc  taaagcaaa  gccaccatt  aagtgaaag  cgctcctga  atcactggc  180
ataaacgga  tgagaacaa  aatgaaggg  aggatgcca  tatgtattg  aagtcagtt  240
gctaccccc  cccagactg  atatggcgc  agaaggaga  cgggatgcc  atggacatt  300
tcaatacct  tggccgctt  ttcatcatc  acaaggaaa  ttacactga  ttgaacatt  360
tgaacctgc  gatcacgga  gaccctggc  agtatgaat  taatgccac  tggccccac  420
ctggccttt  ttgggaatt  tggctgaaa  tatcatcct  gtggtgatc  ttgttgtgt  480
tgagaagag  aagaggcca  atgaggttc  tgacgctgg  ccaatgaaa  ccaactcta  540
caacaatca  aaagataaa  acttgcgcc  gagaaacac  aattaagta  tgcttacaa  600
atctttagg  tcctgaaac  ggtggcaac  tgacctgct  aaattttct  cttggacct  660
tttggttct  tcccctttc  agtgagcaa  accacaatg  ctgtctaaa  catgcctta  720
ttagcctct  ctgtaaggg  gatctagcc  ggtacattt  aaacaatgc  tcagtgtag  780
aggtgtaaa  tattttggg  ttgatgtgc  gtgaatgtt  ctttttttt  tcctttgtt  840
aaatattta  atagaagtg  aaaggtcct  tgaggatca  atcatgcat  cgccatttt  900
tacttaatg  agctgttaa  ttggcaaag  tctaaaatg  actgctgcc  tctagtgat  960
cacttttgt  aagtacagc  aaacctaca  atatataca  tatataaat  tatatatat  1020
tatatttat  tttttgggg  tgggagaaa  ccaaaataa  gtaaatgct  gtttcattt  1080
taagctgct  atattcatt  cttattgta  gttgtcaga  gaggaaatt  tgcagttct  1140
gtacataaa  atgagtaat  taaactgaa  tctataatt  taagggctt  acctgtgac  1200
ttaataagc  ggaacagtc  actgaatgg  tataatgaa  tgcagtata  acgtatgat  1260
gctttttaa  tgattatct  ttcttctgt  aagtcatgt  aattcataa  tccttttgc  1320
ctgatgtgt  gaaccttat  cttgtacat  cattcaatc  aggcaaact  ttataattt  1380
tcttttgtt  ccaatgacc  tgaaatgtt  tagcatggt  atattctat  caactatag  1440
tatactttt  ggtttgaca  tgtattttt  cacattgat  tactggttg  tgatagatt  1500
tataaccta  cggttctca  gcggtgcgt  attgtagat  catgtactt  tgtgttttg  1560
gtaattatt  aagtgcaat  atgtataaa  aagtggatt  acctgtttt  aaaaataaa  1620
cattgataa  aaaaaaaaa  aaaaaa  1646



<210> 10256
<211> 398
<212> PRT
<213> Homo sapiens
<308> NP_036560
<400> 10256

Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu 
  1               5                  10                  15
Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Ala Gly 
             20                  25                  30
Phe Val Lys Ser Pro Met Ser Glu Thr Lys Leu Thr Gly Asp Ala Phe 
         35                  40                  45
Glu Leu Tyr Cys Asp Val Val Gly Ser Pro Thr Pro Glu Ile Gln Trp 
     50                  55                  60
Trp Tyr Ala Glu Val Asn Arg Ala Glu Ser Phe Arg Gln Leu Trp Asp 
 65                  70                  75                  80
Gly Ala Arg Lys Arg Arg Val Thr Val Asn Thr Ala Tyr Gly Ser Asn 
                 85                  90                  95
Gly Val Ser Val Leu Arg Ile Thr Arg Leu Thr Leu Glu Asp Ser Gly 
             100                105                110
Thr Tyr Glu Cys Arg Ala Ser Asn Asp Pro Lys Arg Asn Asp Leu Arg 
         115                120                125
Gln Asn Pro Ser Ile Thr Trp Ile Arg Ala Gln Ala Thr Ile Ser Val 
     130                135                140
Leu Gln Lys Pro Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp 
 145                150                155                160
Ser Pro Val Leu Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser 
                 165                170                175
His Thr Leu Thr Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Ser 
             180                185                190
Ala Thr Arg Lys Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro 
         195                200                205
Arg Ala Glu Asp Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser 
     210                215                220
Ala Pro Lys Ala Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile 
 225                230                235                240
Thr Gly His Lys Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Thr 
                 245                250                255
Met Tyr Cys Lys Ser Val Gly Tyr Pro His Pro Asp Trp Ile Trp Arg 
             260                265                270
Lys Lys Glu Asn Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg 
         275                280                285
Phe Phe Ile Ile Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn 
     290                295                300
Leu Gln Ile Thr Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn 
 305                310                315                320
Ala Ile Gly Ser Ala Ser Val Val Thr Val Leu Arg Val Arg Ser His 
                 325                330                335
Leu Ala Pro Leu Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile 
             340                345                350
Leu Val Val Ile Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu 
         355                360                365
Val Pro Asp Asp Asp Glu Pro Ala Gly Pro Met Lys Thr Asn Ser Thr 
     370                375                380
Asn Asn His Lys Asp Lys Asn Leu Arg Gln Arg Asn Thr Asn 
 385                390                395



<210> 10257
<211> 1271
<212> DNA
<213> Rattus norvegicus
<308> Y00311
<400> 10257

agcgtggac  cagaaggtt  aaggagcaa  aacccctaa  caactcaca  aatggagac  60
gcagtcaat  ctaagagtc  caggaatga  aaggttttg  actgtttgt  tcaaaatcc  120
gatgcagtt  tcaagctga  ctgcttccc  tgggcagga  gcggctcca  ccattttgc  180
aagtggggc  aaaagatta  cgactctct  gaagtgcat  ctgtaagac  ggctggaag  240
gaaacccga  ttggagaac  tttcgcaaa  gacatctac  agatagctg  tgaaatcgt  300
accgccctg  tgcccatca  tcaggataa  gcttttgcg  tttttggcc  cagttttgg  360
tcctacatt  ctcttatta  tgctctgct  ctaaaggag  aatacaaaa  ggagccgct  420
catattttt  tatccggtg  atccgcccc  cactcaaca  cccggcctc  agttcctga  480
cttaacgaa  tgacagaag  acaagtcag  catcacctt  tggatttcg  aggcacgcc  540
aagcatctc  tagaagacc  ggatgttct  aggatgttc  ttcctttgc  gaaggcaga  600
gctggcgtt  tgaaaaaat  catctttga  aagccctcc  aagctcttc  ctctctgga  660
ataacgggc  tccttggat  tgaagatac  ataaaggac  tagaaggct  gcaagacct  720
accagtggg  agtttgatg  ccacatgct  ccaggcgac  acttttatc  gatgaagcc  780
gacaacgag  actttatca  gaactacat  gccaagtgc  tggaactct  gtcactcac  840
tgactactt  tagatgagc  ttctttggg  ctgtggata  gcagacggt  caaaagctg  900
tcctctggg  ccagctttt  gttcttaga  gttggaaag  tgcatatta  tgaatttct  960
cgtggagca  ttatctctc  ggggaaagg  cacggctga  gaggcgcac  ggcactatt  1020
ggagctaac  gaggggaga  gggggtggt  ttctttggg  ggatgttgc  ctcagtagg  1080
acccatgct  cagtaaatg  cactacacc  ttgtggcac  tgcaggcag  tctaatcag  1140
ctcagtggg  agttgggag  catacatgt  gggggacat  tgtcacggg  cttggaaag  1200
caagtgagg  tctgatcaa  acctgctgt  tacattttc  aagaataaa  aaaaaatat  1260
gctaaagga  g  1271



<210> 10258
<211> 263
<212> PRT
<213> Rattus norvegicus
<308> P08635
<400> 10258

Met Glu Thr Ala Val Asn Ala Lys Ser Pro Arg Asn Glu Lys Val Leu 
  1               5                  10                  15
Asn Cys Leu Tyr Gln Asn Pro Asp Ala Val Phe Lys Leu Ile Cys Phe 
             20                  25                  30
Pro Trp Ala Gly Gly Gly Ser Ile His Phe Ala Lys Trp Gly Gln Lys 
         35                  40                  45
Ile Asn Asp Ser Leu Glu Val His Ala Val Arg Leu Ala Gly Arg Glu 
     50                  55                  60
Thr Arg Leu Gly Glu Pro Phe Ala Asn Asp Ile Tyr Gln Ile Ala Asp 
 65                  70                  75                  80
Glu Ile Val Thr Ala Leu Leu Pro Ile Ile Gln Asp Lys Ala Phe Ala 
                 85                  90                  95
Phe Phe Gly His Ser Phe Gly Ser Tyr Ile Ala Leu Ile Thr Ala Leu 
             100                105                110
Leu Leu Lys Glu Lys Tyr Lys Met Glu Pro Leu His Ile Phe Val Ser 
         115                120                125
Gly Ala Ser Ala Pro His Ser Thr Ser Arg Pro Gln Val Pro Asp Leu 
     130                135                140
Asn Glu Leu Thr Glu Glu Gln Val Arg His His Leu Leu Asp Phe Gly 
 145                150                155                160
Gly Thr Pro Lys His Leu Ile Glu Asp Gln Asp Val Leu Arg Met Phe 
                 165                170                175
Ile Pro Leu Leu Lys Ala Asp Ala Gly Val Val Lys Lys Phe Ile Phe 
             180                185                190
Asp Lys Pro Ser Lys Ala Leu Leu Ser Leu Asp Ile Thr Gly Phe Leu 
         195                200                205
Gly Ser Glu Asp Thr Ile Lys Asp Ile Glu Gly Trp Gln Asp Leu Thr 
     210                215                220
Ser Gly Lys Phe Asp Val His Met Leu Pro Gly Asp His Phe Tyr Leu 
 225                230                235                240
Met Lys Pro Asp Asn Glu Asn Phe Ile Lys Asn Tyr Ile Ala Lys Cys 
                 245                250                255
Leu Glu Leu Ser Ser Leu Thr 
             260



<210> 10259
<211> 1765
<212> DNA
<213> Homo sapiens
<308> AK001968
<400> 10259

agagttcat  tcaaagcct  gcaaggatt  gagaggtca  taagagtca  cgcctttaa  60
aagaaatct  ctcactctt  tgtgtgcat  aggccgagc  gaggttctt  gtctcaaga  120
gaactgact  ctgttgagc  ctcaacacg  cacagagac  agccatctt  caacctcac  180
tcacagcat  gagagagga  accaaccta  gagaaccag  aatgaaaac  ttttcaact  240
cttatacaa  aaccctgag  caactttta  gctgatttg  tttccctgg  tgggaggtg  300
ctccactca  tttgccaaa  ggggccaag  tactcatga  ttgctggaa  agacagcat  360
tcaccatgt  gccaaggct  gtctcaaac  ccggcgctc  agtgatcct  ctgcttcag  420
ctacccatg  gctggcgtg  gccaccgta  gcgtgagcc  ccgtgcctg  ccaaaattc  480
tggtctatt  tggattcta  tttttttta  gcactcctt  aggcttcct  gaagagaaa  540
cagagttga  gaacctctt  aaaatgaca  ctcccagtt  gttgatgaa  ttgtttgtg  600
tctgcagcc  gtcatccag  ataaaccat  tgcattttt  ggccacagt  tgggatcct  660
cattgcttt  aggactgca  taggtctaa  agaaaacaa  caaccagaa  cattgcatt  720
atttttgtc  agtgcaact  ctgtacatt  aaaggcctg  catcgcatt  ccaaagatg  780
tgaattgtc  gaagaacaa  taagtcatt  ccttatgga  tttggaggc  cccccaagc  840
ttttgctga  gccaaggaa  ttgtgaaac  atgtagtcc  atcataagg  cagatctga  900
cattgttag  agttgcacc  ctaacgtac  atctaaggc  gttctttcc  gtgacttga  960
atgttttgt  ggatctgaa  acatagcaa  ggacatgga  gcctggaaa  atgtaacca  1020
tggaaatgc  aaaatttac  agcttccag  gggtcactt  tatcttctg  atcctgcga  1080
cgagaaatt  atcaagaac  acataatca  gtgtctaga  gtatcatcg  tatccaatt  1140
ttagatatt  tccctttca  ttttaaaat  atcaaagta  tatcatact  ttctcagtt  1200
ttcagatat  gctcagttt  attcagatt  gaaattaca  attttctac  gtcagggag  1260
ttcgttaca  aaatatatt  acgtatctg  ggacaaagg  caagccagt  aagaatact  1320
ctggcagca  tttgggagg  caaggcggg  ggatcacga  gtcaggaga  cgagaccgt  1380
ctggctaac  ccgtgaaac  ccatctcta  taaaaatac  caaaattag  tgggcgtgg  1440
ggtgggcac  tgtagtccc  gctactcgg  aggctgagg  aggagaatg  tgtgaacct  1500
ggaggtgga  cttgcagtg  accgagatc  ctccactgc  ctccagcct  ggtgacaga  1560
ccagactct  tctcaaaaa  aaaaaaaaa  aatacttct  gcagagtct  ttatcttcc  1620
attaaaatc  cacttgatt  tcctttatg  gaagtttgt  gacaaaatt  atgattagt  1680
aattatcca  tttttcctt  agttagttt  atggtgaag  tgattaaca  gggaaatgc  1740
tgaagtaaa  gattgtttc  atggc  1765



<210> 10260
<211> 319
<212> PRT
<213> Homo sapiens
<308> AK001968
<400> 10260

Met Glu Arg Gly Asp Gln Pro Lys Arg Thr Arg Asn Glu Asn Ile Phe 
  1               5                  10                  15
Asn Cys Leu Tyr Lys Asn Pro Glu Ala Thr Phe Lys Leu Ile Cys Phe 
             20                  25                  30
Pro Trp Met Gly Gly Gly Ser Thr His Phe Ala Lys Trp Gly Gln Asp 
         35                  40                  45
Thr His Asp Leu Leu Glu Glu Thr Ala Ser His His Val Ala Lys Ala 
     50                  55                  60
Gly Leu Lys Leu Arg Arg Ser Ser Asp Pro Pro Ala Ser Ala Tyr Pro 
 65                  70                  75                  80
Cys Ala Gly Val Ser His Arg Arg Arg Glu Pro Pro Cys Leu Ala Lys 
                 85                  90                  95
Ile Leu Gly Leu Phe Trp Ile Leu Ile Phe Phe Met His Ser Leu Arg 
             100                105                110
Leu Pro Gly Arg Glu Ser Arg Val Glu Glu Pro Leu Glu Asn Asp Ile 
         115                120                125
Ser Gln Leu Val Asp Glu Val Val Cys Ala Leu Gln Pro Val Ile Gln 
     130                135                140
Asp Lys Pro Phe Ala Phe Phe Gly His Ser Met Gly Ser Tyr Ile Ala 
 145                150                155                160
Phe Arg Thr Ala Leu Gly Leu Lys Glu Asn Asn Gln Pro Glu Pro Leu 
                 165                170                175
His Leu Phe Leu Ser Ser Ala Thr Pro Val His Ser Lys Ala Trp His 
             180                185                190
Arg Ile Pro Lys Asp Asp Glu Leu Ser Glu Glu Gln Ile Ser His Tyr 
         195                200                205
Leu Met Glu Phe Gly Gly Thr Pro Lys His Phe Ala Glu Ala Lys Glu 
     210                215                220
Phe Val Lys Gln Cys Ser Pro Ile Ile Arg Ala Asp Leu Asn Ile Val 
 225                230                235                240
Arg Ser Cys Thr Ser Asn Val Pro Ser Lys Ala Val Leu Ser Cys Asp 
                 245                250                255
Leu Thr Cys Phe Val Gly Ser Glu Asp Ile Ala Lys Asp Met Glu Ala 
             260                265                270
Trp Lys Asp Val Thr Ser Gly Asn Ala Lys Ile Tyr Gln Leu Pro Gly 
         275                280                285
Gly His Phe Tyr Leu Leu Asp Pro Ala Asn Glu Lys Leu Ile Lys Asn 
     290                295                300
Tyr Ile Ile Lys Cys Leu Glu Val Ser Ser Ile Ser Asn Phe Ter 
 305                310                315



<210> 10261
<211> 3628
<212> DNA
<213> Rattus norvegicus
<308> Y07704
<400> 10261

tggggatgc  agtgcctac  gcgctggct  ctcggctgc  gagcctgtt  cagcaacag  60
tgggttccc  ctggagtgg  ctggccatg  tgttctgct  gctgagaat  gcattgggg  120
ggccagatc  tggaaaggg  cagccacgg  tccggggtg  gcccaagga  actcaggag  180
cccacgaag  tccaggcag  gctcagccc  caacccccg  tagtgtcaa  taccacttc  240
cgcgtcagt  caactacaa  tgtggcttc  gcttccaca  ggccaagac  tccttcgtg  300
tgcccctgg  ggaggccaa  cgaggactg  ttctgctca  acaggctgg  atggagaag  360
tcaactttt  aggaggaga  cccttccta  aggacaggg  tgaatactt  ggcaagctc  420
tgagattct  caaggagga  ctagccctg  cctctgtga  catagtgag  aatggcagc  480
ttatccgag  gagatggtt  aaggactat  gagactatt  ggacattct  gctatctcc  540
gtgacagct  tgatgagca  gttaatgtt  tcattggtc  tggccaagg  aaaaagaac  600
atgtggaaa  ccttcaaaa  ctgcggaag  ggtgcaggg  ttacaaggt  gctttcaag  660
tcaattccg  cattaatcg  ttcaacgtg  acgaagata  gaatgagca  atcaaggcg  720
tgagccctg  ccgctggaa  gttttccaa  gcctcctga  tgagggtga  aactcagga  780
aagatgccc  gagggaagc  gaaagattt  ttataagca  tgaagaatt  gaagcattc  840
tacagcgtc  caaagatgt  tcctgcttg  tgcctgaat  taaccagaa  atgaaagac  900
cctacctta  cctggatga  tatatgcgc  ttttgaact  taccggtgg  cggaaggac  960
cttccaggt  catcctgga  gttggcgtg  aggaagcga  caaattcag  gggtttgat  1020
agaagatgt  tctgaagcg  ggggggaag  atgtatgga  taaggctga  ctgaagcta  1080
actggtgag  tgagattgg  cggagactc  aaccagcta  gaggagtcc  cgagcagcc  1140
ctcgccacc  cgcacatct  gctgtctac  gactgttgc  actgagaat  cactctatg  1200
tctttcttt  agtttgact  aactaagaa  ggagtaaaa  cattctgtg  acccttata  1260
agccgataa  ggtcctcca  aggggaagg  gttcagttc  cagaggaac  aggtccagc  1320
atctcaaag  actcacatt  tatttgtat  cgaattttt  tatggatcg  tactgtgaa  1380
cccatgttt  cttttccct  tctgttccc  catgagaaa  tgggttatt  tctgctaac  1440
atgccagtt  tgtcaacag  aaggatcac  aaacacacc  tgcgattac  gctgactgt  1500
ctaatgctt  tctgctttg  aatctcgga  tttttgctc  gaaatatag  atcaagaag  1560
gtgttatag  gccgtacgt  agaacctta  tcttttgca  ggagcatat  gaaggaggt  1620
cttctgagg  cggtgtgtt  atggcctca  cctctgctg  tgctgctgc  tcaaggatg  1680
ctgttctat  tcgtaccaa  tccttcaag  ttctggaca  agccaaggt  cactttacc  1740
ttcatggca  ggccgtgaa  atggcactg  cagccgcaa  caccccagc  ctgaggctg  1800
ctgagtctg  caggctaaa  ggttgtccc  cttttctga  aagctacaa  ggctcttct  1860
cacatccag  agaatcatg  caggatggg  atggaggac  cttcaggag  atgaaatgt  1920
gctgctgct  cttaccata  ttctcatga  actctgaaa  aagacctag  agtctaggt  1980
accatgaga  aataatttc  tctctacat  aaataagca  aagagagaa  atgaactag  2040
ccaaatctt  ttcctgtgg  agcattgca  gagtttatt  aacctagac  gcctcactg  2100
ttggaaaat  attccctgg  aattaaata  ataccatgg  aaagaaatt  aactcctct  2160
caatcccac  gtggccact  gagggcacc  ggaagtcag  cttcattgt  tcagagact  2220
ttcttcagt  tttttttag  atttggtga  ttttaattc  gttccttat  tgttttgtc  2280
ttgtttttt  ttttggtgc  tattactaa  attaatact  aacattttc  aaggaactg  2340
aattttggc  atttacaaa  ggtcttcat  ctttagtga  gtcactata  ttcaactaa  2400
acatactct  tctcattaa  aataggtca  gttttcctg  gttttctgt  ttgtttggt  2460
gtgtgtgtg  gtttaccta  ttttgcttg  atatagata  aactatgta  cccaggcta  2520
cctggaact  atgatacct  tgccttaac  tccccctct  aagtgccca  gaattaccc  2580
actcctgta  agagatttt  aagagaagt  tgagtcaca  tcccccctg  agattgtga  2640
ttttttttt  aagttaagt  ctgtgtaca  agttcacat  ggaaaccat  acatcccag  2700
ggacatggg  agacaccca  ttggtcaca  gacagaggg  agctgcatg  ttctttccc  2760
aattaaagt  gagcatgaa  aaagtatga  tggaaagtg  gccatcatt  acatgtacc  2820
ccaacccct  gtgcatgca  tggcggtgg  agatctctg  gcttaaaat  ttgaaaagt  2880
ccctttcct  aaagggaaa  attacgata  tttactatc  tagtacaaa  caaacttgg  2940
ttagatcat  cattggttt  ctttttcag  gttaaatkt  ggtgttcat  ttgtaaagc  3000
tacgctccc  gctggggaa  caaggagtg  tctagttga  atttgttaa  tgtgaccag  3060
agatacctt  tgtcccatg  ttgatttat  cagagcagt  atactggga  gggggattt  3120
cttaagaac  tcgacgggt  ggacatcca  cactgattt  aaagttttg  cttctttat  3180
ataatgtgt  cggcggtaa  aaaaagtca  gggttgttt  ctttgaagc  gaaagtctc  3240
tggtgttat  tacctaaat  atctgaaaa  tttaaaagg  gcccaggtt  cattctgcg  3300
tggagtttg  gggtctaat  gttgcataa  taaacaggc  accaatcat  agaggttga  3360
tcctcccat  aataattca  ctcgtgttt  acccttttg  tggactgat  ttgtttcat  3420
agctattag  agtccaaga  caatcatgc  ggcctcatg  gaatgtgtt  agatgaggt  3480
tgatgttcg  gatacatgt  catgtatct  cctgtagaa  gacactgta  tttgaggca  3540
tgctctagt  tatggaaac  tgatctgtg  attaaaatg  tttatgcat  acctcaaaa  3600
aaaaaaaaa  aaaaaaaaa  aaaaaaga  3628



<210> 10262
<211> 360
<212> PRT
<213> Rattus norvegicus
<308> CAA68971
<400> 10262

Met Leu Val Pro Thr Ala Leu Ala Ala Arg Leu Leu Ser Leu Phe Gln 
  1               5                  10                  15
Gln Gln Leu Gly Ser Leu Trp Ser Gly Leu Ala Met Leu Phe Cys Trp 
             20                  25                  30
Leu Arg Ile Ala Leu Gly Trp Pro Asp Pro Gly Lys Gly Gln Pro Arg 
         35                  40                  45
Val Arg Gly Glu Pro Lys Glu Thr Gln Glu Thr His Glu Asp Pro Gly 
     50                  55                  60
Ser Ala Gln Pro Thr Thr Pro Val Ser Val Asn Tyr His Phe Thr Arg 
 65                  70                  75                  80
Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr Ser 
                 85                  90                  95
Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu Lys 
             100                105                110
Gln Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe Leu 
         115                120                125
Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys Glu 
     130                135                140
Glu Leu Ala Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu Ile 
 145                150                155                160
Arg Glu Arg Trp Phe Lys Asp Tyr Gly Asp Tyr Leu Asp Ile Leu Ala 
                 165                170                175
Ile Ser Cys Asp Ser Phe Asp Glu Gln Val Asn Val Leu Ile Gly Arg 
             180                185                190
Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg Lys 
         195                200                205
Trp Cys Arg Asp Tyr Lys Val Ala Phe Lys Ile Asn Ser Val Ile Asn 
     210                215                220
Arg Phe Asn Val Asp Glu Asp Met Asn Glu His Ile Lys Ala Leu Ser 
 225                230                235                240
Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu Asn 
                 245                250                255
Ser Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Leu Ile Ser Asn 
             260                265                270
Glu Glu Phe Glu Ala Phe Leu Gln Arg His Lys Asp Val Ser Cys Leu 
         275                280                285
Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu Asp 
     290                295                300
Glu Tyr Met Arg Phe Leu Asn Cys Thr Gly Gly Arg Lys Asp Pro Ser 
 305                310                315                320
Arg Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser Gly 
                 325                330                335
Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Val Trp Ser 
             340                345                350
Lys Ala Asp Leu Lys Leu Asp Trp 
         355                360



<210> 10263
<211> 1442
<212> DNA
<213> Homo sapiens
<308> BC017969
<400> 10263

gctctgctc  aggcatctg  cacaatgtg  gtgcttaca  ctgctgctt  tgctgggaa  60
ctcttgagt  tgttcaggc  acctctgag  tctctgtgg  ggagcctgg  cccgctgtt  120
tgctggctg  gggcaacct  ctggctgcg  gctaccaag  ggagaaagc  gcagctggt  180
ctgagaggg  cagatgaga  caaagagga  gaagaggac  ctcctctgc  caccacccc  240
accagcgtc  actatcact  cactcgcca  tgcaactac  aatgcggct  ctgtttcca  300
acagccaaa  catcctttg  gctgcccct  gaggaagca  agagaggat  gcttttgct  360
aaggaagct  gtatggaga  gatcaactt  tcaggtgga  agccatttc  tcaagaccg  420
ggagaatac  tgggcaagt  ggtgaggtt  tgcaaagta  agttgcggc  gcccagcgt  480
agcatcgtg  gcaatggaa  cctgatccg  gagaggtgg  tccagaatt  tggtgagta  540
ttggacatt  tcgctatct  ctgtgacag  tttgacgag  aagtcaatg  ccttattgg  600
cgtggccaa  gaaagaaga  ccatgtgga  aaccttcaa  agctgagga  gtggtgtag  660
gattataga  tcgctttca  gataaattc  gtcattaat  gtttcaacg  ggaagagga  720
atgacggaa  agatcaaag  actaaaccc  gtccgctgg  aagtgttcc  gtgcctctt  780
attgagggt  agaattgtg  agaagatgc  ctaagagaa  cagaaagat  tgttattgg  840
gatgaagaa  ttgaaagat  cttggagcg  cacaaagaa  tgtcctgct  ggtgcctga  900
tctaaccag  agatgaaag  ctcctacct  attctggat  aatatatgc  ctttctgaa  960
tgtagaaag  gacggaagg  cccttccaa  tccatcctg  atgttggtg  agaagaagc  1020
ataaaattc  gtggatttg  tgaaaagat  tttctgaag  gaggaggaa  atacatatg  1080
agtaaggct  atctgaagc  ggattggta  agcggaaag  ggaacgaga  ttcaacaca  1140
cagtgggaa  actcctaga  taactgcca  tgtctgcaa  actatcccg  tggtatttc  1200
cagtggctg  aaacctgat  ttctgctgc  cgtggcatc  gattacctg  ggtcactga  1260
cacacgaat  acttggata  caaatcctg  gacaatgga  aaccattaa  tttacttca  1320
tggcttata  ccttgttgt  attgaaaca  cacttctgt  tttgagttt  ttttagcta  1380
aaagaagga  tacacacag  aataatgac  ccaaaaaaa  aaaaaaaaa  aaaaaaaaa  1440
aa  1442



<210> 10264
<211> 362
<212> PRT
<213> Homo sapiens
<308> BC017969
<400> 10264

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
  1               5                  10                  15
Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
             20                  25                  30
Cys Trp Leu Arg Ala Thr Phe Trp Leu Arg Ala Thr Lys Arg Arg Lys 
         35                  40                  45
Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
     50                  55                  60
Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
 65                  70                  75                  80
Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                 85                  90                  95
Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
             100                105                110
Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
         115                120                125
Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
     130                135                140
Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
 145                150                155                160
Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                 165                170                175
Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
             180                185                190
Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
         195                200                205
Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
     210                215                220
Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
 225                230                235                240
Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                 245                250                255
Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
             260                265                270
Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
         275                280                285
Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
     290                295                300
Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
 305                310                315                320
Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                 325                330                335
Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
             340                345                350
Ser Lys Ala Asp Leu Lys Leu Asp Trp Ter 
         355                360



<210> 10265
<211> 3628
<212> DNA
<213> Rattus norvegicus
<308> Y07704
<400> 10265

tggggatgc  agtgcctac  gcgctggct  ctcggctgc  gagcctgtt  cagcaacag  60
tgggttccc  ctggagtgg  ctggccatg  tgttctgct  gctgagaat  gcattgggg  120
ggccagatc  tggaaaggg  cagccacgg  tccggggtg  gcccaagga  actcaggag  180
cccacgaag  tccaggcag  gctcagccc  caacccccg  tagtgtcaa  taccacttc  240
cgcgtcagt  caactacaa  tgtggcttc  gcttccaca  ggccaagac  tccttcgtg  300
tgcccctgg  ggaggccaa  cgaggactg  ttctgctca  acaggctgg  atggagaag  360
tcaactttt  aggaggaga  cccttccta  aggacaggg  tgaatactt  ggcaagctc  420
tgagattct  caaggagga  ctagccctg  cctctgtga  catagtgag  aatggcagc  480
ttatccgag  gagatggtt  aaggactat  gagactatt  ggacattct  gctatctcc  540
gtgacagct  tgatgagca  gttaatgtt  tcattggtc  tggccaagg  aaaaagaac  600
atgtggaaa  ccttcaaaa  ctgcggaag  ggtgcaggg  ttacaaggt  gctttcaag  660
tcaattccg  cattaatcg  ttcaacgtg  acgaagata  gaatgagca  atcaaggcg  720
tgagccctg  ccgctggaa  gttttccaa  gcctcctga  tgagggtga  aactcagga  780
aagatgccc  gagggaagc  gaaagattt  ttataagca  tgaagaatt  gaagcattc  840
tacagcgtc  caaagatgt  tcctgcttg  tgcctgaat  taaccagaa  atgaaagac  900
cctacctta  cctggatga  tatatgcgc  ttttgaact  taccggtgg  cggaaggac  960
cttccaggt  catcctgga  gttggcgtg  aggaagcga  caaattcag  gggtttgat  1020
agaagatgt  tctgaagcg  ggggggaag  atgtatgga  taaggctga  ctgaagcta  1080
actggtgag  tgagattgg  cggagactc  aaccagcta  gaggagtcc  cgagcagcc  1140
ctcgccacc  cgcacatct  gctgtctac  gactgttgc  actgagaat  cactctatg  1200
tctttcttt  agtttgact  aactaagaa  ggagtaaaa  cattctgtg  acccttata  1260
agccgataa  ggtcctcca  aggggaagg  gttcagttc  cagaggaac  aggtccagc  1320
atctcaaag  actcacatt  tatttgtat  cgaattttt  tatggatcg  tactgtgaa  1380
cccatgttt  cttttccct  tctgttccc  catgagaaa  tgggttatt  tctgctaac  1440
atgccagtt  tgtcaacag  aaggatcac  aaacacacc  tgcgattac  gctgactgt  1500
ctaatgctt  tctgctttg  aatctcgga  tttttgctc  gaaatatag  atcaagaag  1560
gtgttatag  gccgtacgt  agaacctta  tcttttgca  ggagcatat  gaaggaggt  1620
cttctgagg  cggtgtgtt  atggcctca  cctctgctg  tgctgctgc  tcaaggatg  1680
ctgttctat  tcgtaccaa  tccttcaag  ttctggaca  agccaaggt  cactttacc  1740
ttcatggca  ggccgtgaa  atggcactg  cagccgcaa  caccccagc  ctgaggctg  1800
ctgagtctg  caggctaaa  ggttgtccc  cttttctga  aagctacaa  ggctcttct  1860
cacatccag  agaatcatg  caggatggg  atggaggac  cttcaggag  atgaaatgt  1920
gctgctgct  cttaccata  ttctcatga  actctgaaa  aagacctag  agtctaggt  1980
accatgaga  aataatttc  tctctacat  aaataagca  aagagagaa  atgaactag  2040
ccaaatctt  ttcctgtgg  agcattgca  gagtttatt  aacctagac  gcctcactg  2100
ttggaaaat  attccctgg  aattaaata  ataccatgg  aaagaaatt  aactcctct  2160
caatcccac  gtggccact  gagggcacc  ggaagtcag  cttcattgt  tcagagact  2220
ttcttcagt  tttttttag  atttggtga  ttttaattc  gttccttat  tgttttgtc  2280
ttgtttttt  ttttggtgc  tattactaa  attaatact  aacattttc  aaggaactg  2340
aattttggc  atttacaaa  ggtcttcat  ctttagtga  gtcactata  ttcaactaa  2400
acatactct  tctcattaa  aataggtca  gttttcctg  gttttctgt  ttgtttggt  2460
gtgtgtgtg  gtttaccta  ttttgcttg  atatagata  aactatgta  cccaggcta  2520
cctggaact  atgatacct  tgccttaac  tccccctct  aagtgccca  gaattaccc  2580
actcctgta  agagatttt  aagagaagt  tgagtcaca  tcccccctg  agattgtga  2640
ttttttttt  aagttaagt  ctgtgtaca  agttcacat  ggaaaccat  acatcccag  2700
ggacatggg  agacaccca  ttggtcaca  gacagaggg  agctgcatg  ttctttccc  2760
aattaaagt  gagcatgaa  aaagtatga  tggaaagtg  gccatcatt  acatgtacc  2820
ccaacccct  gtgcatgca  tggcggtgg  agatctctg  gcttaaaat  ttgaaaagt  2880
ccctttcct  aaagggaaa  attacgata  tttactatc  tagtacaaa  caaacttgg  2940
ttagatcat  cattggttt  ctttttcag  gttaaatkt  ggtgttcat  ttgtaaagc  3000
tacgctccc  gctggggaa  caaggagtg  tctagttga  atttgttaa  tgtgaccag  3060
agatacctt  tgtcccatg  ttgatttat  cagagcagt  atactggga  gggggattt  3120
cttaagaac  tcgacgggt  ggacatcca  cactgattt  aaagttttg  cttctttat  3180
ataatgtgt  cggcggtaa  aaaaagtca  gggttgttt  ctttgaagc  gaaagtctc  3240
tggtgttat  tacctaaat  atctgaaaa  tttaaaagg  gcccaggtt  cattctgcg  3300
tggagtttg  gggtctaat  gttgcataa  taaacaggc  accaatcat  agaggttga  3360
tcctcccat  aataattca  ctcgtgttt  acccttttg  tggactgat  ttgtttcat  3420
agctattag  agtccaaga  caatcatgc  ggcctcatg  gaatgtgtt  agatgaggt  3480
tgatgttcg  gatacatgt  catgtatct  cctgtagaa  gacactgta  tttgaggca  3540
tgctctagt  tatggaaac  tgatctgtg  attaaaatg  tttatgcat  acctcaaaa  3600
aaaaaaaaa  aaaaaaaaa  aaaaaaga  3628



<210> 10266
<211> 360
<212> PRT
<213> Rattus norvegicus
<308> CAA68971
<400> 10266

Met Leu Val Pro Thr Ala Leu Ala Ala Arg Leu Leu Ser Leu Phe Gln 
  1               5                  10                  15
Gln Gln Leu Gly Ser Leu Trp Ser Gly Leu Ala Met Leu Phe Cys Trp 
             20                  25                  30
Leu Arg Ile Ala Leu Gly Trp Pro Asp Pro Gly Lys Gly Gln Pro Arg 
         35                  40                  45
Val Arg Gly Glu Pro Lys Glu Thr Gln Glu Thr His Glu Asp Pro Gly 
     50                  55                  60
Ser Ala Gln Pro Thr Thr Pro Val Ser Val Asn Tyr His Phe Thr Arg 
 65                  70                  75                  80
Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr Ser 
                 85                  90                  95
Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu Lys 
             100                105                110
Gln Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe Leu 
         115                120                125
Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys Glu 
     130                135                140
Glu Leu Ala Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu Ile 
 145                150                155                160
Arg Glu Arg Trp Phe Lys Asp Tyr Gly Asp Tyr Leu Asp Ile Leu Ala 
                 165                170                175
Ile Ser Cys Asp Ser Phe Asp Glu Gln Val Asn Val Leu Ile Gly Arg 
             180                185                190
Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg Lys 
         195                200                205
Trp Cys Arg Asp Tyr Lys Val Ala Phe Lys Ile Asn Ser Val Ile Asn 
     210                215                220
Arg Phe Asn Val Asp Glu Asp Met Asn Glu His Ile Lys Ala Leu Ser 
 225                230                235                240
Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu Asn 
                 245                250                255
Ser Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Leu Ile Ser Asn 
             260                265                270
Glu Glu Phe Glu Ala Phe Leu Gln Arg His Lys Asp Val Ser Cys Leu 
         275                280                285
Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu Asp 
     290                295                300
Glu Tyr Met Arg Phe Leu Asn Cys Thr Gly Gly Arg Lys Asp Pro Ser 
 305                310                315                320
Arg Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser Gly 
                 325                330                335
Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Val Trp Ser 
             340                345                350
Lys Ala Asp Leu Lys Leu Asp Trp 
         355                360



<210> 10267
<211> 1442
<212> DNA
<213> Homo sapiens
<308> BC017969
<400> 10267

gctctgctc  aggcatctg  cacaatgtg  gtgcttaca  ctgctgctt  tgctgggaa  60
ctcttgagt  tgttcaggc  acctctgag  tctctgtgg  ggagcctgg  cccgctgtt  120
tgctggctg  gggcaacct  ctggctgcg  gctaccaag  ggagaaagc  gcagctggt  180
ctgagaggg  cagatgaga  caaagagga  gaagaggac  ctcctctgc  caccacccc  240
accagcgtc  actatcact  cactcgcca  tgcaactac  aatgcggct  ctgtttcca  300
acagccaaa  catcctttg  gctgcccct  gaggaagca  agagaggat  gcttttgct  360
aaggaagct  gtatggaga  gatcaactt  tcaggtgga  agccatttc  tcaagaccg  420
ggagaatac  tgggcaagt  ggtgaggtt  tgcaaagta  agttgcggc  gcccagcgt  480
agcatcgtg  gcaatggaa  cctgatccg  gagaggtgg  tccagaatt  tggtgagta  540
ttggacatt  tcgctatct  ctgtgacag  tttgacgag  aagtcaatg  ccttattgg  600
cgtggccaa  gaaagaaga  ccatgtgga  aaccttcaa  agctgagga  gtggtgtag  660
gattataga  tcgctttca  gataaattc  gtcattaat  gtttcaacg  ggaagagga  720
atgacggaa  agatcaaag  actaaaccc  gtccgctgg  aagtgttcc  gtgcctctt  780
attgagggt  agaattgtg  agaagatgc  ctaagagaa  cagaaagat  tgttattgg  840
gatgaagaa  ttgaaagat  cttggagcg  cacaaagaa  tgtcctgct  ggtgcctga  900
tctaaccag  agatgaaag  ctcctacct  attctggat  aatatatgc  ctttctgaa  960
tgtagaaag  gacggaagg  cccttccaa  tccatcctg  atgttggtg  agaagaagc  1020
ataaaattc  gtggatttg  tgaaaagat  tttctgaag  gaggaggaa  atacatatg  1080
agtaaggct  atctgaagc  ggattggta  agcggaaag  ggaacgaga  ttcaacaca  1140
cagtgggaa  actcctaga  taactgcca  tgtctgcaa  actatcccg  tggtatttc  1200
cagtggctg  aaacctgat  ttctgctgc  cgtggcatc  gattacctg  ggtcactga  1260
cacacgaat  acttggata  caaatcctg  gacaatgga  aaccattaa  tttacttca  1320
tggcttata  ccttgttgt  attgaaaca  cacttctgt  tttgagttt  ttttagcta  1380
aaagaagga  tacacacag  aataatgac  ccaaaaaaa  aaaaaaaaa  aaaaaaaaa  1440
aa  1442



<210> 10268
<211> 362
<212> PRT
<213> Homo sapiens
<308> BC017969
<400> 10268

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
  1               5                  10                  15
Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
             20                  25                  30
Cys Trp Leu Arg Ala Thr Phe Trp Leu Arg Ala Thr Lys Arg Arg Lys 
         35                  40                  45
Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
     50                  55                  60
Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
 65                  70                  75                  80
Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                 85                  90                  95
Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
             100                105                110
Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
         115                120                125
Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
     130                135                140
Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
 145                150                155                160
Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                 165                170                175
Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
             180                185                190
Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
         195                200                205
Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
     210                215                220
Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
 225                230                235                240
Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                 245                250                255
Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
             260                265                270
Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
         275                280                285
Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
     290                295                300
Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
 305                310                315                320
Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                 325                330                335
Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
             340                345                350
Ser Lys Ala Asp Leu Lys Leu Asp Trp Ter 
         355                360



<210> 10269
<211> 3628
<212> DNA
<213> Rattus norvegicus
<308> Y07704
<400> 10269

tggggatgc  agtgcctac  gcgctggct  ctcggctgc  gagcctgtt  cagcaacag  60
tgggttccc  ctggagtgg  ctggccatg  tgttctgct  gctgagaat  gcattgggg  120
ggccagatc  tggaaaggg  cagccacgg  tccggggtg  gcccaagga  actcaggag  180
cccacgaag  tccaggcag  gctcagccc  caacccccg  tagtgtcaa  taccacttc  240
cgcgtcagt  caactacaa  tgtggcttc  gcttccaca  ggccaagac  tccttcgtg  300
tgcccctgg  ggaggccaa  cgaggactg  ttctgctca  acaggctgg  atggagaag  360
tcaactttt  aggaggaga  cccttccta  aggacaggg  tgaatactt  ggcaagctc  420
tgagattct  caaggagga  ctagccctg  cctctgtga  catagtgag  aatggcagc  480
ttatccgag  gagatggtt  aaggactat  gagactatt  ggacattct  gctatctcc  540
gtgacagct  tgatgagca  gttaatgtt  tcattggtc  tggccaagg  aaaaagaac  600
atgtggaaa  ccttcaaaa  ctgcggaag  ggtgcaggg  ttacaaggt  gctttcaag  660
tcaattccg  cattaatcg  ttcaacgtg  acgaagata  gaatgagca  atcaaggcg  720
tgagccctg  ccgctggaa  gttttccaa  gcctcctga  tgagggtga  aactcagga  780
aagatgccc  gagggaagc  gaaagattt  ttataagca  tgaagaatt  gaagcattc  840
tacagcgtc  caaagatgt  tcctgcttg  tgcctgaat  taaccagaa  atgaaagac  900
cctacctta  cctggatga  tatatgcgc  ttttgaact  taccggtgg  cggaaggac  960
cttccaggt  catcctgga  gttggcgtg  aggaagcga  caaattcag  gggtttgat  1020
agaagatgt  tctgaagcg  ggggggaag  atgtatgga  taaggctga  ctgaagcta  1080
actggtgag  tgagattgg  cggagactc  aaccagcta  gaggagtcc  cgagcagcc  1140
ctcgccacc  cgcacatct  gctgtctac  gactgttgc  actgagaat  cactctatg  1200
tctttcttt  agtttgact  aactaagaa  ggagtaaaa  cattctgtg  acccttata  1260
agccgataa  ggtcctcca  aggggaagg  gttcagttc  cagaggaac  aggtccagc  1320
atctcaaag  actcacatt  tatttgtat  cgaattttt  tatggatcg  tactgtgaa  1380
cccatgttt  cttttccct  tctgttccc  catgagaaa  tgggttatt  tctgctaac  1440
atgccagtt  tgtcaacag  aaggatcac  aaacacacc  tgcgattac  gctgactgt  1500
ctaatgctt  tctgctttg  aatctcgga  tttttgctc  gaaatatag  atcaagaag  1560
gtgttatag  gccgtacgt  agaacctta  tcttttgca  ggagcatat  gaaggaggt  1620
cttctgagg  cggtgtgtt  atggcctca  cctctgctg  tgctgctgc  tcaaggatg  1680
ctgttctat  tcgtaccaa  tccttcaag  ttctggaca  agccaaggt  cactttacc  1740
ttcatggca  ggccgtgaa  atggcactg  cagccgcaa  caccccagc  ctgaggctg  1800
ctgagtctg  caggctaaa  ggttgtccc  cttttctga  aagctacaa  ggctcttct  1860
cacatccag  agaatcatg  caggatggg  atggaggac  cttcaggag  atgaaatgt  1920
gctgctgct  cttaccata  ttctcatga  actctgaaa  aagacctag  agtctaggt  1980
accatgaga  aataatttc  tctctacat  aaataagca  aagagagaa  atgaactag  2040
ccaaatctt  ttcctgtgg  agcattgca  gagtttatt  aacctagac  gcctcactg  2100
ttggaaaat  attccctgg  aattaaata  ataccatgg  aaagaaatt  aactcctct  2160
caatcccac  gtggccact  gagggcacc  ggaagtcag  cttcattgt  tcagagact  2220
ttcttcagt  tttttttag  atttggtga  ttttaattc  gttccttat  tgttttgtc  2280
ttgtttttt  ttttggtgc  tattactaa  attaatact  aacattttc  aaggaactg  2340
aattttggc  atttacaaa  ggtcttcat  ctttagtga  gtcactata  ttcaactaa  2400
acatactct  tctcattaa  aataggtca  gttttcctg  gttttctgt  ttgtttggt  2460
gtgtgtgtg  gtttaccta  ttttgcttg  atatagata  aactatgta  cccaggcta  2520
cctggaact  atgatacct  tgccttaac  tccccctct  aagtgccca  gaattaccc  2580
actcctgta  agagatttt  aagagaagt  tgagtcaca  tcccccctg  agattgtga  2640
ttttttttt  aagttaagt  ctgtgtaca  agttcacat  ggaaaccat  acatcccag  2700
ggacatggg  agacaccca  ttggtcaca  gacagaggg  agctgcatg  ttctttccc  2760
aattaaagt  gagcatgaa  aaagtatga  tggaaagtg  gccatcatt  acatgtacc  2820
ccaacccct  gtgcatgca  tggcggtgg  agatctctg  gcttaaaat  ttgaaaagt  2880
ccctttcct  aaagggaaa  attacgata  tttactatc  tagtacaaa  caaacttgg  2940
ttagatcat  cattggttt  ctttttcag  gttaaatkt  ggtgttcat  ttgtaaagc  3000
tacgctccc  gctggggaa  caaggagtg  tctagttga  atttgttaa  tgtgaccag  3060
agatacctt  tgtcccatg  ttgatttat  cagagcagt  atactggga  gggggattt  3120
cttaagaac  tcgacgggt  ggacatcca  cactgattt  aaagttttg  cttctttat  3180
ataatgtgt  cggcggtaa  aaaaagtca  gggttgttt  ctttgaagc  gaaagtctc  3240
tggtgttat  tacctaaat  atctgaaaa  tttaaaagg  gcccaggtt  cattctgcg  3300
tggagtttg  gggtctaat  gttgcataa  taaacaggc  accaatcat  agaggttga  3360
tcctcccat  aataattca  ctcgtgttt  acccttttg  tggactgat  ttgtttcat  3420
agctattag  agtccaaga  caatcatgc  ggcctcatg  gaatgtgtt  agatgaggt  3480
tgatgttcg  gatacatgt  catgtatct  cctgtagaa  gacactgta  tttgaggca  3540
tgctctagt  tatggaaac  tgatctgtg  attaaaatg  tttatgcat  acctcaaaa  3600
aaaaaaaaa  aaaaaaaaa  aaaaaaga  3628



<210> 10270
<211> 360
<212> PRT
<213> Rattus norvegicus
<308> CAA68971
<400> 10270

Met Leu Val Pro Thr Ala Leu Ala Ala Arg Leu Leu Ser Leu Phe Gln 
  1               5                  10                  15
Gln Gln Leu Gly Ser Leu Trp Ser Gly Leu Ala Met Leu Phe Cys Trp 
             20                  25                  30
Leu Arg Ile Ala Leu Gly Trp Pro Asp Pro Gly Lys Gly Gln Pro Arg 
         35                  40                  45
Val Arg Gly Glu Pro Lys Glu Thr Gln Glu Thr His Glu Asp Pro Gly 
     50                  55                  60
Ser Ala Gln Pro Thr Thr Pro Val Ser Val Asn Tyr His Phe Thr Arg 
 65                  70                  75                  80
Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr Ser 
                 85                  90                  95
Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu Lys 
             100                105                110
Gln Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe Leu 
         115                120                125
Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys Glu 
     130                135                140
Glu Leu Ala Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu Ile 
 145                150                155                160
Arg Glu Arg Trp Phe Lys Asp Tyr Gly Asp Tyr Leu Asp Ile Leu Ala 
                 165                170                175
Ile Ser Cys Asp Ser Phe Asp Glu Gln Val Asn Val Leu Ile Gly Arg 
             180                185                190
Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg Lys 
         195                200                205
Trp Cys Arg Asp Tyr Lys Val Ala Phe Lys Ile Asn Ser Val Ile Asn 
     210                215                220
Arg Phe Asn Val Asp Glu Asp Met Asn Glu His Ile Lys Ala Leu Ser 
 225                230                235                240
Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu Asn 
                 245                250                255
Ser Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Leu Ile Ser Asn 
             260                265                270
Glu Glu Phe Glu Ala Phe Leu Gln Arg His Lys Asp Val Ser Cys Leu 
         275                280                285
Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu Asp 
     290                295                300
Glu Tyr Met Arg Phe Leu Asn Cys Thr Gly Gly Arg Lys Asp Pro Ser 
 305                310                315                320
Arg Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser Gly 
                 325                330                335
Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Val Trp Ser 
             340                345                350
Lys Ala Asp Leu Lys Leu Asp Trp 
         355                360



<210> 10271
<211> 1442
<212> DNA
<213> Homo sapiens
<308> BC017969
<400> 10271

gctctgctc  aggcatctg  cacaatgtg  gtgcttaca  ctgctgctt  tgctgggaa  60
ctcttgagt  tgttcaggc  acctctgag  tctctgtgg  ggagcctgg  cccgctgtt  120
tgctggctg  gggcaacct  ctggctgcg  gctaccaag  ggagaaagc  gcagctggt  180
ctgagaggg  cagatgaga  caaagagga  gaagaggac  ctcctctgc  caccacccc  240
accagcgtc  actatcact  cactcgcca  tgcaactac  aatgcggct  ctgtttcca  300
acagccaaa  catcctttg  gctgcccct  gaggaagca  agagaggat  gcttttgct  360
aaggaagct  gtatggaga  gatcaactt  tcaggtgga  agccatttc  tcaagaccg  420
ggagaatac  tgggcaagt  ggtgaggtt  tgcaaagta  agttgcggc  gcccagcgt  480
agcatcgtg  gcaatggaa  cctgatccg  gagaggtgg  tccagaatt  tggtgagta  540
ttggacatt  tcgctatct  ctgtgacag  tttgacgag  aagtcaatg  ccttattgg  600
cgtggccaa  gaaagaaga  ccatgtgga  aaccttcaa  agctgagga  gtggtgtag  660
gattataga  tcgctttca  gataaattc  gtcattaat  gtttcaacg  ggaagagga  720
atgacggaa  agatcaaag  actaaaccc  gtccgctgg  aagtgttcc  gtgcctctt  780
attgagggt  agaattgtg  agaagatgc  ctaagagaa  cagaaagat  tgttattgg  840
gatgaagaa  ttgaaagat  cttggagcg  cacaaagaa  tgtcctgct  ggtgcctga  900
tctaaccag  agatgaaag  ctcctacct  attctggat  aatatatgc  ctttctgaa  960
tgtagaaag  gacggaagg  cccttccaa  tccatcctg  atgttggtg  agaagaagc  1020
ataaaattc  gtggatttg  tgaaaagat  tttctgaag  gaggaggaa  atacatatg  1080
agtaaggct  atctgaagc  ggattggta  agcggaaag  ggaacgaga  ttcaacaca  1140
cagtgggaa  actcctaga  taactgcca  tgtctgcaa  actatcccg  tggtatttc  1200
cagtggctg  aaacctgat  ttctgctgc  cgtggcatc  gattacctg  ggtcactga  1260
cacacgaat  acttggata  caaatcctg  gacaatgga  aaccattaa  tttacttca  1320
tggcttata  ccttgttgt  attgaaaca  cacttctgt  tttgagttt  ttttagcta  1380
aaagaagga  tacacacag  aataatgac  ccaaaaaaa  aaaaaaaaa  aaaaaaaaa  1440
aa  1442



<210> 10272
<211> 362
<212> PRT
<213> Homo sapiens
<308> BC017969
<400> 10272

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
  1               5                  10                  15
Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
             20                  25                  30
Cys Trp Leu Arg Ala Thr Phe Trp Leu Arg Ala Thr Lys Arg Arg Lys 
         35                  40                  45
Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
     50                  55                  60
Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
 65                  70                  75                  80
Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                 85                  90                  95
Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
             100                105                110
Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
         115                120                125
Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
     130                135                140
Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
 145                150                155                160
Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                 165                170                175
Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
             180                185                190
Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
         195                200                205
Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
     210                215                220
Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
 225                230                235                240
Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                 245                250                255
Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
             260                265                270
Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
         275                280                285
Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
     290                295                300
Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
 305                310                315                320
Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                 325                330                335
Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
             340                345                350
Ser Lys Ala Asp Leu Lys Leu Asp Trp Ter 
         355                360



<210> 10273
<211> 3628
<212> DNA
<213> Rattus norvegicus
<308> Y07704
<400> 10273

tggggatgc  agtgcctac  gcgctggct  ctcggctgc  gagcctgtt  cagcaacag  60
tgggttccc  ctggagtgg  ctggccatg  tgttctgct  gctgagaat  gcattgggg  120
ggccagatc  tggaaaggg  cagccacgg  tccggggtg  gcccaagga  actcaggag  180
cccacgaag  tccaggcag  gctcagccc  caacccccg  tagtgtcaa  taccacttc  240
cgcgtcagt  caactacaa  tgtggcttc  gcttccaca  ggccaagac  tccttcgtg  300
tgcccctgg  ggaggccaa  cgaggactg  ttctgctca  acaggctgg  atggagaag  360
tcaactttt  aggaggaga  cccttccta  aggacaggg  tgaatactt  ggcaagctc  420
tgagattct  caaggagga  ctagccctg  cctctgtga  catagtgag  aatggcagc  480
ttatccgag  gagatggtt  aaggactat  gagactatt  ggacattct  gctatctcc  540
gtgacagct  tgatgagca  gttaatgtt  tcattggtc  tggccaagg  aaaaagaac  600
atgtggaaa  ccttcaaaa  ctgcggaag  ggtgcaggg  ttacaaggt  gctttcaag  660
tcaattccg  cattaatcg  ttcaacgtg  acgaagata  gaatgagca  atcaaggcg  720
tgagccctg  ccgctggaa  gttttccaa  gcctcctga  tgagggtga  aactcagga  780
aagatgccc  gagggaagc  gaaagattt  ttataagca  tgaagaatt  gaagcattc  840
tacagcgtc  caaagatgt  tcctgcttg  tgcctgaat  taaccagaa  atgaaagac  900
cctacctta  cctggatga  tatatgcgc  ttttgaact  taccggtgg  cggaaggac  960
cttccaggt  catcctgga  gttggcgtg  aggaagcga  caaattcag  gggtttgat  1020
agaagatgt  tctgaagcg  ggggggaag  atgtatgga  taaggctga  ctgaagcta  1080
actggtgag  tgagattgg  cggagactc  aaccagcta  gaggagtcc  cgagcagcc  1140
ctcgccacc  cgcacatct  gctgtctac  gactgttgc  actgagaat  cactctatg  1200
tctttcttt  agtttgact  aactaagaa  ggagtaaaa  cattctgtg  acccttata  1260
agccgataa  ggtcctcca  aggggaagg  gttcagttc  cagaggaac  aggtccagc  1320
atctcaaag  actcacatt  tatttgtat  cgaattttt  tatggatcg  tactgtgaa  1380
cccatgttt  cttttccct  tctgttccc  catgagaaa  tgggttatt  tctgctaac  1440
atgccagtt  tgtcaacag  aaggatcac  aaacacacc  tgcgattac  gctgactgt  1500
ctaatgctt  tctgctttg  aatctcgga  tttttgctc  gaaatatag  atcaagaag  1560
gtgttatag  gccgtacgt  agaacctta  tcttttgca  ggagcatat  gaaggaggt  1620
cttctgagg  cggtgtgtt  atggcctca  cctctgctg  tgctgctgc  tcaaggatg  1680
ctgttctat  tcgtaccaa  tccttcaag  ttctggaca  agccaaggt  cactttacc  1740
ttcatggca  ggccgtgaa  atggcactg  cagccgcaa  caccccagc  ctgaggctg  1800
ctgagtctg  caggctaaa  ggttgtccc  cttttctga  aagctacaa  ggctcttct  1860
cacatccag  agaatcatg  caggatggg  atggaggac  cttcaggag  atgaaatgt  1920
gctgctgct  cttaccata  ttctcatga  actctgaaa  aagacctag  agtctaggt  1980
accatgaga  aataatttc  tctctacat  aaataagca  aagagagaa  atgaactag  2040
ccaaatctt  ttcctgtgg  agcattgca  gagtttatt  aacctagac  gcctcactg  2100
ttggaaaat  attccctgg  aattaaata  ataccatgg  aaagaaatt  aactcctct  2160
caatcccac  gtggccact  gagggcacc  ggaagtcag  cttcattgt  tcagagact  2220
ttcttcagt  tttttttag  atttggtga  ttttaattc  gttccttat  tgttttgtc  2280
ttgtttttt  ttttggtgc  tattactaa  attaatact  aacattttc  aaggaactg  2340
aattttggc  atttacaaa  ggtcttcat  ctttagtga  gtcactata  ttcaactaa  2400
acatactct  tctcattaa  aataggtca  gttttcctg  gttttctgt  ttgtttggt  2460
gtgtgtgtg  gtttaccta  ttttgcttg  atatagata  aactatgta  cccaggcta  2520
cctggaact  atgatacct  tgccttaac  tccccctct  aagtgccca  gaattaccc  2580
actcctgta  agagatttt  aagagaagt  tgagtcaca  tcccccctg  agattgtga  2640
ttttttttt  aagttaagt  ctgtgtaca  agttcacat  ggaaaccat  acatcccag  2700
ggacatggg  agacaccca  ttggtcaca  gacagaggg  agctgcatg  ttctttccc  2760
aattaaagt  gagcatgaa  aaagtatga  tggaaagtg  gccatcatt  acatgtacc  2820
ccaacccct  gtgcatgca  tggcggtgg  agatctctg  gcttaaaat  ttgaaaagt  2880
ccctttcct  aaagggaaa  attacgata  tttactatc  tagtacaaa  caaacttgg  2940
ttagatcat  cattggttt  ctttttcag  gttaaatkt  ggtgttcat  ttgtaaagc  3000
tacgctccc  gctggggaa  caaggagtg  tctagttga  atttgttaa  tgtgaccag  3060
agatacctt  tgtcccatg  ttgatttat  cagagcagt  atactggga  gggggattt  3120
cttaagaac  tcgacgggt  ggacatcca  cactgattt  aaagttttg  cttctttat  3180
ataatgtgt  cggcggtaa  aaaaagtca  gggttgttt  ctttgaagc  gaaagtctc  3240
tggtgttat  tacctaaat  atctgaaaa  tttaaaagg  gcccaggtt  cattctgcg  3300
tggagtttg  gggtctaat  gttgcataa  taaacaggc  accaatcat  agaggttga  3360
tcctcccat  aataattca  ctcgtgttt  acccttttg  tggactgat  ttgtttcat  3420
agctattag  agtccaaga  caatcatgc  ggcctcatg  gaatgtgtt  agatgaggt  3480
tgatgttcg  gatacatgt  catgtatct  cctgtagaa  gacactgta  tttgaggca  3540
tgctctagt  tatggaaac  tgatctgtg  attaaaatg  tttatgcat  acctcaaaa  3600
aaaaaaaaa  aaaaaaaaa  aaaaaaga  3628



<210> 10274
<211> 360
<212> PRT
<213> Rattus norvegicus
<308> CAA68971
<400> 10274

Met Leu Val Pro Thr Ala Leu Ala Ala Arg Leu Leu Ser Leu Phe Gln 
  1               5                  10                  15
Gln Gln Leu Gly Ser Leu Trp Ser Gly Leu Ala Met Leu Phe Cys Trp 
             20                  25                  30
Leu Arg Ile Ala Leu Gly Trp Pro Asp Pro Gly Lys Gly Gln Pro Arg 
         35                  40                  45
Val Arg Gly Glu Pro Lys Glu Thr Gln Glu Thr His Glu Asp Pro Gly 
     50                  55                  60
Ser Ala Gln Pro Thr Thr Pro Val Ser Val Asn Tyr His Phe Thr Arg 
 65                  70                  75                  80
Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr Ser 
                 85                  90                  95
Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu Lys 
             100                105                110
Gln Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe Leu 
         115                120                125
Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys Glu 
     130                135                140
Glu Leu Ala Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu Ile 
 145                150                155                160
Arg Glu Arg Trp Phe Lys Asp Tyr Gly Asp Tyr Leu Asp Ile Leu Ala 
                 165                170                175
Ile Ser Cys Asp Ser Phe Asp Glu Gln Val Asn Val Leu Ile Gly Arg 
             180                185                190
Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg Lys 
         195                200                205
Trp Cys Arg Asp Tyr Lys Val Ala Phe Lys Ile Asn Ser Val Ile Asn 
     210                215                220
Arg Phe Asn Val Asp Glu Asp Met Asn Glu His Ile Lys Ala Leu Ser 
 225                230                235                240
Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu Asn 
                 245                250                255
Ser Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Leu Ile Ser Asn 
             260                265                270
Glu Glu Phe Glu Ala Phe Leu Gln Arg His Lys Asp Val Ser Cys Leu 
         275                280                285
Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu Asp 
     290                295                300
Glu Tyr Met Arg Phe Leu Asn Cys Thr Gly Gly Arg Lys Asp Pro Ser 
 305                310                315                320
Arg Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser Gly 
                 325                330                335
Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Val Trp Ser 
             340                345                350
Lys Ala Asp Leu Lys Leu Asp Trp 
         355                360



<210> 10275
<211> 1442
<212> DNA
<213> Homo sapiens
<308> BC017969
<400> 10275

gctctgctc  aggcatctg  cacaatgtg  gtgcttaca  ctgctgctt  tgctgggaa  60
ctcttgagt  tgttcaggc  acctctgag  tctctgtgg  ggagcctgg  cccgctgtt  120
tgctggctg  gggcaacct  ctggctgcg  gctaccaag  ggagaaagc  gcagctggt  180
ctgagaggg  cagatgaga  caaagagga  gaagaggac  ctcctctgc  caccacccc  240
accagcgtc  actatcact  cactcgcca  tgcaactac  aatgcggct  ctgtttcca  300
acagccaaa  catcctttg  gctgcccct  gaggaagca  agagaggat  gcttttgct  360
aaggaagct  gtatggaga  gatcaactt  tcaggtgga  agccatttc  tcaagaccg  420
ggagaatac  tgggcaagt  ggtgaggtt  tgcaaagta  agttgcggc  gcccagcgt  480
agcatcgtg  gcaatggaa  cctgatccg  gagaggtgg  tccagaatt  tggtgagta  540
ttggacatt  tcgctatct  ctgtgacag  tttgacgag  aagtcaatg  ccttattgg  600
cgtggccaa  gaaagaaga  ccatgtgga  aaccttcaa  agctgagga  gtggtgtag  660
gattataga  tcgctttca  gataaattc  gtcattaat  gtttcaacg  ggaagagga  720
atgacggaa  agatcaaag  actaaaccc  gtccgctgg  aagtgttcc  gtgcctctt  780
attgagggt  agaattgtg  agaagatgc  ctaagagaa  cagaaagat  tgttattgg  840
gatgaagaa  ttgaaagat  cttggagcg  cacaaagaa  tgtcctgct  ggtgcctga  900
tctaaccag  agatgaaag  ctcctacct  attctggat  aatatatgc  ctttctgaa  960
tgtagaaag  gacggaagg  cccttccaa  tccatcctg  atgttggtg  agaagaagc  1020
ataaaattc  gtggatttg  tgaaaagat  tttctgaag  gaggaggaa  atacatatg  1080
agtaaggct  atctgaagc  ggattggta  agcggaaag  ggaacgaga  ttcaacaca  1140
cagtgggaa  actcctaga  taactgcca  tgtctgcaa  actatcccg  tggtatttc  1200
cagtggctg  aaacctgat  ttctgctgc  cgtggcatc  gattacctg  ggtcactga  1260
cacacgaat  acttggata  caaatcctg  gacaatgga  aaccattaa  tttacttca  1320
tggcttata  ccttgttgt  attgaaaca  cacttctgt  tttgagttt  ttttagcta  1380
aaagaagga  tacacacag  aataatgac  ccaaaaaaa  aaaaaaaaa  aaaaaaaaa  1440
aa  1442



<210> 10276
<211> 362
<212> PRT
<213> Homo sapiens
<308> BC017969
<400> 10276

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
  1               5                  10                  15
Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
             20                  25                  30
Cys Trp Leu Arg Ala Thr Phe Trp Leu Arg Ala Thr Lys Arg Arg Lys 
         35                  40                  45
Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
     50                  55                  60
Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
 65                  70                  75                  80
Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                 85                  90                  95
Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
             100                105                110
Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
         115                120                125
Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
     130                135                140
Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
 145                150                155                160
Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                 165                170                175
Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
             180                185                190
Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
         195                200                205
Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
     210                215                220
Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
 225                230                235                240
Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                 245                250                255
Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
             260                265                270
Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
         275                280                285
Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
     290                295                300
Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
 305                310                315                320
Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                 325                330                335
Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
             340                345                350
Ser Lys Ala Asp Leu Lys Leu Asp Trp Ter 
         355                360



<210> 10277
<211> 1711
<212> DNA
<213> Rattus norvegicus
<308> Y09333
<400> 10277

cgggcctac  gctcagtct  aggactgca  ataggcagc  ggccactag  ggatctcta  60
cttttccta  gaaactgag  gctgaagtc  aagatacaa  atggtggcc  cgtctttcg  120
tgtcctgag  gcaagcagg  tgtgccaat  gggttggaa  agctggacg  agctgtcag  180
tcctccgcc  ctcagcacc  gtggccgga  cacttttgc  cggacaaat  ctacgctga  240
cctggagcc  gggagccgc  gctgctggg  cgagccgtt  agcatcacc  tgcgcggcc  300
ggcccccga  cagcccgtc  cgctgcgcg  ggccctgcg  gacgagaag  gcgcgctct  360
ccgagccca  gcgcgctac  gcgccgacg  cggtggtga  ctggacctg  cgcgcgctc  420
cgcgctggg  ggcagcttc  cggggctcg  gcccatggg  ctgatctgg  ccatggagc  480
cgaacggcc  ctctggcgc  tggtcaagc  cgacgtgca  aagccttat  tggtggagc  540
ggaggtgct  gacggacac  agcccgacg  cggtcagcg  ctggcacag  cagtgcacg  600
gcgtcactt  atggctcca  gggtgcggc  cgtgcccgt  cgcgacggg  gggtgcgcg  660
cacgctctt  ctgccccca  aacctgggc  ctttcctga  atcatagac  tttttggag  720
tggaggcgg  cttctggag  accgggcga  tctgctggc  gggaagggt  ttgccgtca  780
ggctctggc  tattacaac  acgacgacc  ccccaagac  atggaaacc  tgcgcattg  840
gtactttga  gaagccgtg  actacctgc  tggccaccc  gaggtaaaa  gaccaggaa  900
tgggctgct  gggatttcc  aagggggtg  acttggcct  gctatggcc  ccttcctga  960
gggcatcac  gctgctgtt  tcatcaatg  ctccgtggc  gctgttggg  acaccgtat  1020
ctacaagga  gagactata  cccctgtgt  ccttctgag  gacaaagtc  aaatgacca  1080
agatggtct  ttggatgtc  tggaagctc  gcaaagccc  ttggtagac  agaagagct  1140
catccctgt  gaaaggtct  acacgacct  cctgttcct  gttggtcag  atgaccaca  1200
ctggaagag  gagttctat  ccagagagg  ctccaaacg  ttgcaggcc  acgggaaag  1260
gaagcccca  atcatctgc  acccagaag  agggcacta  atcgagcct  cttacttcc  1320
actgtgcag  gctggcatg  acctcttgg  gggtgctaa  atcaccttt  gaggggagc  1380
taagcctca  tctgtggcc  agttggatg  atggcagca  ctccagact  tcttccaca  1440
acagttgag  ggtaagagt  aggaggtgc  ccctaaaat  taacctgtt  tgtggtggt  1500
tggggaaaa  cccaaatat  agaatgcca  ttcagttta  ttcatttga  cacatacta  1560
tttttttaa  tttctttct  ccttccttt  tttctttct  ttttttttt  ttgttgttg  1620
tgttgttgt  tgtttgttt  tttgagaca  ggtttgtct  tttacccct  gctggcctg  1680
aacttgctt  gtagaccag  ggctaggcc  g  1711



<210> 10278
<211> 453
<212> PRT
<213> Rattus norvegicus
<308> O55171
<400> 10278

Met Val Ala Ser Ser Phe Ala Val Leu Arg Ala Ser Arg Leu Cys Gln 
  1               5                  10                  15
Trp Gly Trp Lys Ser Trp Thr Gln Leu Ser Gly Pro Pro Pro Leu Ser 
             20                  25                  30
Thr Gly Gly Arg Thr Thr Phe Ala Arg Thr Asn Ala Thr Leu Ser Leu 
         35                  40                  45
Glu Pro Gly Ser Arg Ser Cys Trp Asp Glu Pro Leu Ser Ile Thr Val 
     50                  55                  60
Arg Gly Leu Ala Pro Glu Gln Pro Val Thr Leu Arg Ala Ala Leu Arg 
 65                  70                  75                  80
Asp Glu Lys Gly Ala Leu Phe Arg Ala His Ala Arg Tyr Arg Ala Asp 
                 85                  90                  95
Ala Gly Gly Glu Leu Asp Leu Ala Arg Ala Pro Ala Leu Gly Gly Ser 
             100                105                110
Phe Thr Gly Leu Glu Pro Met Gly Leu Ile Trp Ala Met Glu Pro Glu 
         115                120                125
Arg Pro Leu Trp Arg Leu Val Lys Arg Asp Val Gln Lys Pro Tyr Val 
     130                135                140
Val Glu Leu Glu Val Leu Asp Gly His Glu Pro Asp Gly Gly Gln Arg 
 145                150                155                160
Leu Ala Gln Ala Val His Glu Arg His Phe Met Ala Pro Gly Val Arg 
                 165                170                175
Arg Val Pro Val Arg Asp Gly Arg Val Arg Ala Thr Leu Phe Leu Pro 
             180                185                190
Pro Glu Pro Gly Pro Phe Pro Glu Ile Ile Asp Leu Phe Gly Val Gly 
         195                200                205
Gly Gly Leu Leu Glu Tyr Arg Ala Ser Leu Leu Ala Gly Lys Gly Phe 
     210                215                220
Ala Val Met Ala Leu Ala Tyr Tyr Asn Tyr Asp Asp Leu Pro Lys Thr 
 225                230                235                240
Met Glu Thr Met Arg Ile Glu Tyr Phe Glu Glu Ala Val Asn Tyr Leu 
                 245                250                255
Arg Gly His Pro Glu Val Lys Gly Pro Gly Ile Gly Leu Leu Gly Ile 
             260                265                270
Ser Lys Gly Gly Glu Leu Gly Leu Ala Met Ala Ser Phe Leu Lys Gly 
         275                280                285
Ile Thr Ala Ala Val Val Ile Asn Gly Ser Val Ala Ala Val Gly Asn 
     290                295                300
Thr Val Cys Tyr Lys Asp Glu Thr Ile Pro Pro Val Ser Leu Leu Arg 
 305                310                315                320
Asp Lys Val Lys Met Thr Lys Asp Gly Leu Leu Asp Val Val Glu Ala 
                 325                330                335
Leu Gln Ser Pro Leu Val Asp Lys Lys Ser Phe Ile Pro Val Glu Arg 
             340                345                350
Ser Asp Thr Thr Phe Leu Phe Leu Val Gly Gln Asp Asp His Asn Trp 
         355                360                365
Lys Ser Glu Phe Tyr Ala Arg Glu Ala Ser Lys Arg Leu Gln Ala His 
     370                375                380
Gly Lys Glu Lys Pro Gln Ile Ile Cys Tyr Pro Glu Ala Gly His Tyr 
 385                390                395                400
Ile Glu Pro Pro Tyr Phe Pro Leu Cys Ser Ala Gly Met His Leu Leu 
                 405                410                415
Val Gly Ala Asn Ile Thr Phe Gly Gly Glu Pro Lys Pro His Ser Val 
             420                425                430
Ala Gln Leu Asp Ala Trp Gln Gln Leu Gln Thr Phe Phe His Lys Gln 
         435                440                445
Leu Ser Gly Lys Ser 
     450



<210> 10279
<211> 1143
<212> DNA
<213> Homo sapiens
<308> L40401
<400> 10279

cccccgggc  gcaggaatt  ctgaattca  aatggcctc  tctcctgct  tccttcgag  60
gtcccggct  taccaatgg  gcctgaaga  ttcggcgca  ttcctgggg  ctccacagc  120
gaggcagaa  ctgggccct  tcctgggat  gtggacatg  tcgggaact  gaggtggcc  180
gctggagta  cgggctagt  tgctggctg  gaagggttt  gctgtgatg  ctctggctt  240
ttataacta  gaagacctc  ccaagacca  ggagacgct  catctggag  actttgaag  300
agccatgaa  tacttgctc  gtcatcccg  ggtaaaagg  ccaggagtt  ggctgcttg  360
aatttccaa  gggggtgag  tctgccttt  catggcctc  ttcctgaag  gcatcacgg  420
tgctgtcgt  atcaacggc  ctgtggcca  tgttggggg  accttacac  acaagggcg  480
gaccctgcc  cctgtgggc  tcaacagaa  tcgcatcaa  gtgaccaaa  atggctatg  540
agacattgt  gatgtcctg  acagccctt  ggaaggacc  gaccagaag  gcttcattc  600
tgtggaaag  gcagagagc  ccttcctgt  cctggtagg  caggatgac  acaactgga  660
gagtgagtt  tatgctaat  aggcctgta  acgcttgca  gcccatggg  ggagaaagc  720
ccagatcat  tgttaccca  agacagggc  ctatattga  cctccttac  tccccctgt  780
tcgggcttc  ctgcatgcc  tggtgggca  tcctattat  tggggaggg  agcccaggg  840
tcatgccat  gctcaggtg  atgcttgga  acaactcca  actttcttc  acaaacact  900
gggtggcca  gaggggaca  tcccatcaa  agtgtaaat  ttatttgat  atgtggcct  960
tctgttgct  atctctcct  gaaacatct  ccacattta  tgtgtgtat  tgtattcat  1020
cttttgttt  taataacta  agttttttc  cctcattat  aaaatgaat  taccagtaa  1080
aaaaaaaaa  aaaaaaaaa  aaaaaaagg  attcgatat  aagcttatc  ataccgtcg  1140
cct  1143



<210> 10280
<211> 421
<212> PRT
<213> Homo sapiens
<308> P49753
<400> 10280

Met Ala Ala Thr Leu Ile Leu Glu Pro Ala Gly Arg Cys Cys Trp Asp 
  1               5                  10                  15
Glu Pro Val Arg Ile Ala Val Arg Gly Leu Ala Pro Glu Gln Pro Val 
             20                  25                  30
Thr Leu Arg Ala Ser Leu Arg Asp Glu Lys Gly Ala Leu Phe Gln Ala 
         35                  40                  45
His Ala Arg Tyr Arg Ala Asp Thr Leu Gly Glu Leu Asp Leu Glu Arg 
     50                  55                  60
Ala Pro Ala Leu Gly Gly Ser Phe Ala Gly Leu Glu Pro Met Gly Leu 
 65                  70                  75                  80
Leu Trp Ala Leu Glu Pro Glu Lys Pro Leu Val Arg Leu Val Lys Arg 
                 85                  90                  95
Asp Val Arg Thr Pro Leu Ala Val Glu Leu Glu Val Leu Asp Gly His 
             100                105                110
Asp Pro Asp Pro Gly Arg Leu Leu Cys Gln Thr Arg His Glu Arg Tyr 
         115                120                125
Phe Leu Pro Pro Gly Val Arg Arg Glu Pro Val Arg Val Gly Arg Val 
     130                135                140
Arg Gly Thr Leu Phe Leu Pro Pro Glu Pro Gly Pro Phe Pro Gly Ile 
 145                150                155                160
Val Asp Met Phe Gly Thr Gly Gly Gly Leu Leu Glu Tyr Arg Ala Ser 
                 165                170                175
Leu Leu Ala Gly Lys Gly Phe Ala Val Met Ala Leu Ala Tyr Tyr Asn 
             180                185                190
Tyr Glu Asp Leu Pro Lys Thr Met Glu Thr Leu His Leu Glu Tyr Phe 
         195                200                205
Glu Glu Ala Met Asn Tyr Leu Leu Ser His Pro Glu Val Lys Gly Pro 
     210                215                220
Gly Val Gly Leu Leu Gly Ile Ser Lys Gly Gly Glu Leu Cys Leu Ser 
 225                230                235                240
Met Ala Ser Phe Leu Lys Gly Ile Thr Ala Ala Val Val Ile Asn Gly 
                 245                250                255
Ser Val Ala Asn Val Gly Gly Thr Leu Arg Tyr Lys Gly Glu Thr Leu 
             260                265                270
Pro Pro Val Gly Val Asn Arg Asn Arg Ile Lys Val Thr Lys Asp Gly 
         275                280                285
Tyr Ala Asp Ile Val Asp Val Leu Asn Ser Pro Leu Glu Gly Pro Asp 
     290                295                300
Gln Lys Ser Phe Ile Pro Val Glu Arg Ala Glu Ser Thr Phe Leu Phe 
 305                310                315                320
Leu Val Gly Gln Asp Asp His Asn Trp Lys Ser Glu Phe Tyr Ala Asn 
                 325                330                335
Glu Ala Cys Lys Arg Leu Gln Ala His Gly Arg Arg Lys Pro Gln Ile 
             340                345                350
Ile Cys Tyr Pro Glu Thr Gly His Tyr Ile Glu Pro Pro Tyr Phe Pro 
         355                360                365
Leu Cys Arg Ala Ser Leu His Ala Leu Val Gly Ser Pro Ile Ile Trp 
     370                375                380
Gly Gly Glu Pro Arg Ala His Ala Met Ala Gln Val Asp Ala Trp Lys 
 385                390                395                400
Gln Leu Gln Thr Phe Phe His Lys His Leu Gly Gly Arg Glu Gly Thr 
                 405                410                415
Ile Pro Ser Lys Val 
             420



<210> 10281
<211> 1711
<212> DNA
<213> Rattus norvegicus
<308> Y09333
<400> 10281

cgggcctac  gctcagtct  aggactgca  ataggcagc  ggccactag  ggatctcta  60
cttttccta  gaaactgag  gctgaagtc  aagatacaa  atggtggcc  cgtctttcg  120
tgtcctgag  gcaagcagg  tgtgccaat  gggttggaa  agctggacg  agctgtcag  180
tcctccgcc  ctcagcacc  gtggccgga  cacttttgc  cggacaaat  ctacgctga  240
cctggagcc  gggagccgc  gctgctggg  cgagccgtt  agcatcacc  tgcgcggcc  300
ggcccccga  cagcccgtc  cgctgcgcg  ggccctgcg  gacgagaag  gcgcgctct  360
ccgagccca  gcgcgctac  gcgccgacg  cggtggtga  ctggacctg  cgcgcgctc  420
cgcgctggg  ggcagcttc  cggggctcg  gcccatggg  ctgatctgg  ccatggagc  480
cgaacggcc  ctctggcgc  tggtcaagc  cgacgtgca  aagccttat  tggtggagc  540
ggaggtgct  gacggacac  agcccgacg  cggtcagcg  ctggcacag  cagtgcacg  600
gcgtcactt  atggctcca  gggtgcggc  cgtgcccgt  cgcgacggg  gggtgcgcg  660
cacgctctt  ctgccccca  aacctgggc  ctttcctga  atcatagac  tttttggag  720
tggaggcgg  cttctggag  accgggcga  tctgctggc  gggaagggt  ttgccgtca  780
ggctctggc  tattacaac  acgacgacc  ccccaagac  atggaaacc  tgcgcattg  840
gtactttga  gaagccgtg  actacctgc  tggccaccc  gaggtaaaa  gaccaggaa  900
tgggctgct  gggatttcc  aagggggtg  acttggcct  gctatggcc  ccttcctga  960
gggcatcac  gctgctgtt  tcatcaatg  ctccgtggc  gctgttggg  acaccgtat  1020
ctacaagga  gagactata  cccctgtgt  ccttctgag  gacaaagtc  aaatgacca  1080
agatggtct  ttggatgtc  tggaagctc  gcaaagccc  ttggtagac  agaagagct  1140
catccctgt  gaaaggtct  acacgacct  cctgttcct  gttggtcag  atgaccaca  1200
ctggaagag  gagttctat  ccagagagg  ctccaaacg  ttgcaggcc  acgggaaag  1260
gaagcccca  atcatctgc  acccagaag  agggcacta  atcgagcct  cttacttcc  1320
actgtgcag  gctggcatg  acctcttgg  gggtgctaa  atcaccttt  gaggggagc  1380
taagcctca  tctgtggcc  agttggatg  atggcagca  ctccagact  tcttccaca  1440
acagttgag  ggtaagagt  aggaggtgc  ccctaaaat  taacctgtt  tgtggtggt  1500
tggggaaaa  cccaaatat  agaatgcca  ttcagttta  ttcatttga  cacatacta  1560
tttttttaa  tttctttct  ccttccttt  tttctttct  ttttttttt  ttgttgttg  1620
tgttgttgt  tgtttgttt  tttgagaca  ggtttgtct  tttacccct  gctggcctg  1680
aacttgctt  gtagaccag  ggctaggcc  g  1711



<210> 10282
<211> 453
<212> PRT
<213> Rattus norvegicus
<308> O55171
<400> 10282

Met Val Ala Ser Ser Phe Ala Val Leu Arg Ala Ser Arg Leu Cys Gln 
  1               5                  10                  15
Trp Gly Trp Lys Ser Trp Thr Gln Leu Ser Gly Pro Pro Pro Leu Ser 
             20                  25                  30
Thr Gly Gly Arg Thr Thr Phe Ala Arg Thr Asn Ala Thr Leu Ser Leu 
         35                  40                  45
Glu Pro Gly Ser Arg Ser Cys Trp Asp Glu Pro Leu Ser Ile Thr Val 
     50                  55                  60
Arg Gly Leu Ala Pro Glu Gln Pro Val Thr Leu Arg Ala Ala Leu Arg 
 65                  70                  75                  80
Asp Glu Lys Gly Ala Leu Phe Arg Ala His Ala Arg Tyr Arg Ala Asp 
                 85                  90                  95
Ala Gly Gly Glu Leu Asp Leu Ala Arg Ala Pro Ala Leu Gly Gly Ser 
             100                105                110
Phe Thr Gly Leu Glu Pro Met Gly Leu Ile Trp Ala Met Glu Pro Glu 
         115                120                125
Arg Pro Leu Trp Arg Leu Val Lys Arg Asp Val Gln Lys Pro Tyr Val 
     130                135                140
Val Glu Leu Glu Val Leu Asp Gly His Glu Pro Asp Gly Gly Gln Arg 
 145                150                155                160
Leu Ala Gln Ala Val His Glu Arg His Phe Met Ala Pro Gly Val Arg 
                 165                170                175
Arg Val Pro Val Arg Asp Gly Arg Val Arg Ala Thr Leu Phe Leu Pro 
             180                185                190
Pro Glu Pro Gly Pro Phe Pro Glu Ile Ile Asp Leu Phe Gly Val Gly 
         195                200                205
Gly Gly Leu Leu Glu Tyr Arg Ala Ser Leu Leu Ala Gly Lys Gly Phe 
     210                215                220
Ala Val Met Ala Leu Ala Tyr Tyr Asn Tyr Asp Asp Leu Pro Lys Thr 
 225                230                235                240
Met Glu Thr Met Arg Ile Glu Tyr Phe Glu Glu Ala Val Asn Tyr Leu 
                 245                250                255
Arg Gly His Pro Glu Val Lys Gly Pro Gly Ile Gly Leu Leu Gly Ile 
             260                265                270
Ser Lys Gly Gly Glu Leu Gly Leu Ala Met Ala Ser Phe Leu Lys Gly 
         275                280                285
Ile Thr Ala Ala Val Val Ile Asn Gly Ser Val Ala Ala Val Gly Asn 
     290                295                300
Thr Val Cys Tyr Lys Asp Glu Thr Ile Pro Pro Val Ser Leu Leu Arg 
 305                310                315                320
Asp Lys Val Lys Met Thr Lys Asp Gly Leu Leu Asp Val Val Glu Ala 
                 325                330                335
Leu Gln Ser Pro Leu Val Asp Lys Lys Ser Phe Ile Pro Val Glu Arg 
             340                345                350
Ser Asp Thr Thr Phe Leu Phe Leu Val Gly Gln Asp Asp His Asn Trp 
         355                360                365
Lys Ser Glu Phe Tyr Ala Arg Glu Ala Ser Lys Arg Leu Gln Ala His 
     370                375                380
Gly Lys Glu Lys Pro Gln Ile Ile Cys Tyr Pro Glu Ala Gly His Tyr 
 385                390                395                400
Ile Glu Pro Pro Tyr Phe Pro Leu Cys Ser Ala Gly Met His Leu Leu 
                 405                410                415
Val Gly Ala Asn Ile Thr Phe Gly Gly Glu Pro Lys Pro His Ser Val 
             420                425                430
Ala Gln Leu Asp Ala Trp Gln Gln Leu Gln Thr Phe Phe His Lys Gln 
         435                440                445
Leu Ser Gly Lys Ser 
     450



<210> 10283
<211> 1143
<212> DNA
<213> Homo sapiens
<308> L40401
<400> 10283

cccccgggc  gcaggaatt  ctgaattca  aatggcctc  tctcctgct  tccttcgag  60
gtcccggct  taccaatgg  gcctgaaga  ttcggcgca  ttcctgggg  ctccacagc  120
gaggcagaa  ctgggccct  tcctgggat  gtggacatg  tcgggaact  gaggtggcc  180
gctggagta  cgggctagt  tgctggctg  gaagggttt  gctgtgatg  ctctggctt  240
ttataacta  gaagacctc  ccaagacca  ggagacgct  catctggag  actttgaag  300
agccatgaa  tacttgctc  gtcatcccg  ggtaaaagg  ccaggagtt  ggctgcttg  360
aatttccaa  gggggtgag  tctgccttt  catggcctc  ttcctgaag  gcatcacgg  420
tgctgtcgt  atcaacggc  ctgtggcca  tgttggggg  accttacac  acaagggcg  480
gaccctgcc  cctgtgggc  tcaacagaa  tcgcatcaa  gtgaccaaa  atggctatg  540
agacattgt  gatgtcctg  acagccctt  ggaaggacc  gaccagaag  gcttcattc  600
tgtggaaag  gcagagagc  ccttcctgt  cctggtagg  caggatgac  acaactgga  660
gagtgagtt  tatgctaat  aggcctgta  acgcttgca  gcccatggg  ggagaaagc  720
ccagatcat  tgttaccca  agacagggc  ctatattga  cctccttac  tccccctgt  780
tcgggcttc  ctgcatgcc  tggtgggca  tcctattat  tggggaggg  agcccaggg  840
tcatgccat  gctcaggtg  atgcttgga  acaactcca  actttcttc  acaaacact  900
gggtggcca  gaggggaca  tcccatcaa  agtgtaaat  ttatttgat  atgtggcct  960
tctgttgct  atctctcct  gaaacatct  ccacattta  tgtgtgtat  tgtattcat  1020
cttttgttt  taataacta  agttttttc  cctcattat  aaaatgaat  taccagtaa  1080
aaaaaaaaa  aaaaaaaaa  aaaaaaagg  attcgatat  aagcttatc  ataccgtcg  1140
cct  1143



<210> 10284
<211> 421
<212> PRT
<213> Homo sapiens
<308> P49753
<400> 10284

Met Ala Ala Thr Leu Ile Leu Glu Pro Ala Gly Arg Cys Cys Trp Asp 
  1               5                  10                  15
Glu Pro Val Arg Ile Ala Val Arg Gly Leu Ala Pro Glu Gln Pro Val 
             20                  25                  30
Thr Leu Arg Ala Ser Leu Arg Asp Glu Lys Gly Ala Leu Phe Gln Ala 
         35                  40                  45
His Ala Arg Tyr Arg Ala Asp Thr Leu Gly Glu Leu Asp Leu Glu Arg 
     50                  55                  60
Ala Pro Ala Leu Gly Gly Ser Phe Ala Gly Leu Glu Pro Met Gly Leu 
 65                  70                  75                  80
Leu Trp Ala Leu Glu Pro Glu Lys Pro Leu Val Arg Leu Val Lys Arg 
                 85                  90                  95
Asp Val Arg Thr Pro Leu Ala Val Glu Leu Glu Val Leu Asp Gly His 
             100                105                110
Asp Pro Asp Pro Gly Arg Leu Leu Cys Gln Thr Arg His Glu Arg Tyr 
         115                120                125
Phe Leu Pro Pro Gly Val Arg Arg Glu Pro Val Arg Val Gly Arg Val 
     130                135                140
Arg Gly Thr Leu Phe Leu Pro Pro Glu Pro Gly Pro Phe Pro Gly Ile 
 145                150                155                160
Val Asp Met Phe Gly Thr Gly Gly Gly Leu Leu Glu Tyr Arg Ala Ser 
                 165                170                175
Leu Leu Ala Gly Lys Gly Phe Ala Val Met Ala Leu Ala Tyr Tyr Asn 
             180                185                190
Tyr Glu Asp Leu Pro Lys Thr Met Glu Thr Leu His Leu Glu Tyr Phe 
         195                200                205
Glu Glu Ala Met Asn Tyr Leu Leu Ser His Pro Glu Val Lys Gly Pro 
     210                215                220
Gly Val Gly Leu Leu Gly Ile Ser Lys Gly Gly Glu Leu Cys Leu Ser 
 225                230                235                240
Met Ala Ser Phe Leu Lys Gly Ile Thr Ala Ala Val Val Ile Asn Gly 
                 245                250                255
Ser Val Ala Asn Val Gly Gly Thr Leu Arg Tyr Lys Gly Glu Thr Leu 
             260                265                270
Pro Pro Val Gly Val Asn Arg Asn Arg Ile Lys Val Thr Lys Asp Gly 
         275                280                285
Tyr Ala Asp Ile Val Asp Val Leu Asn Ser Pro Leu Glu Gly Pro Asp 
     290                295                300
Gln Lys Ser Phe Ile Pro Val Glu Arg Ala Glu Ser Thr Phe Leu Phe 
 305                310                315                320
Leu Val Gly Gln Asp Asp His Asn Trp Lys Ser Glu Phe Tyr Ala Asn 
                 325                330                335
Glu Ala Cys Lys Arg Leu Gln Ala His Gly Arg Arg Lys Pro Gln Ile 
             340                345                350
Ile Cys Tyr Pro Glu Thr Gly His Tyr Ile Glu Pro Pro Tyr Phe Pro 
         355                360                365
Leu Cys Arg Ala Ser Leu His Ala Leu Val Gly Ser Pro Ile Ile Trp 
     370                375                380
Gly Gly Glu Pro Arg Ala His Ala Met Ala Gln Val Asp Ala Trp Lys 
 385                390                395                400
Gln Leu Gln Thr Phe Phe His Lys His Leu Gly Gly Arg Glu Gly Thr 
                 405                410                415
Ile Pro Ser Lys Val 
             420



<210> 10285
<211> 2711
<212> DNA
<213> Rattus norvegicus
<308> Y09507
<400> 10285

ccgcctccc  ccccgcttc  ggacttgcc  ctttcttct  cgcgtgagg  cagagccgg  60
gcttaggcc  gagcgagcc  aggggctgc  ggccggtga  gacaccgcg  gcaccgatt  120
gccatggag  gcgccggcg  cgagaacga  aagaaaaag  tgagttccg  acgtcgaaa  180
gaaaagtct  gggatgcag  acgatctcg  cgaagcaaa  agtctgaag  tttttatga  240
cttgctcat  agttgccac  tccccacaa  gtgagctcc  atcttgata  agcttctgt  300
atgaggctc  ccatcagtt  cttacgtgt  aggaaactt  tagatgctg  tgatcttga  360
attgaagat  aaatgaaag  acagatgaa  tgcttttat  tgaaagccc  ggatggctt  420
gttatggtg  taacagatg  tggtgacat  atttacatt  ctgataacg  gaacaaata  480
atggggttg  ctcagtttg  actaactgg  cacagtgtg  ttgatttta  ccatccatg  540
gaccatgag  aaatgagag  aatgcttac  cacagaaat  gcccagtga  aaaggggaa  600
gaacaaaac  cgcagcgaa  cttttttct  agaatgaaa  gtaccctaa  aagccgggg  660
aggacgatg  acatcaagt  agcaacgtg  aaggtgctg  actgcacag  ccacattca  720
gtgtatgat  ccagcagta  ccagccgca  tgtggctac  agaaaccgc  tatgacgtg  780
ttggtgctg  tttgtgaac  cattcctca  ccatcaaac  ttgaaattc  tttagacag  840
aagacattt  tcagtcgac  cagcctcga  atgaaattt  cttactgtg  tgaaaggat  900
actgagttg  tgggttatg  gccagaaga  cttttgggc  gttcaattt  tgaatatta  960
catgctttg  actctgatc  tctgaccaa  actcatcat  acatgttta  taaaggaca  1020
gtcaccaca  gacagtaca  gatgcttgc  aaaagaggt  gatatgtct  ggttgagac  1080
caagcaact  ttatatata  tacgaagga  tctcagcca  agtgcattg  gtgtgtgaa  1140
tatgttgta  gtggtatta  tcagcacga  ttgattttc  cccttcaac  aacagaatc  1200
gtcctcaaa  cagttgaat  ttcagatat  aaaatgacc  agctgttca  taaagtgga  1260
tctgaggac  cgagctgcc  cttcgacaa  cttaagaaa  agcccgatg  cctgactct  1320
ctagctcca  cggctgggg  cacgatcat  tcactggac  tcggcagcg  tgacacgga  1380
actgaagac  aacaacttg  agatgtccc  ttgtacaat  atgtaatgt  cccctcttc  1440
aatgagaaa  taaatataa  tctggcaat  tctccatta  ctgcctctg  aactccaaa  1500
ccacttcga  gtagtgctg  tcctgcact  aaccaagag  ttgcattga  gttagagtc  1560
agcccagag  cactgggac  ttcttttac  atgccccag  ttcaagatc  gccagcaag  1620
ccttctgat  gaagcacta  acaaagctc  cctgagcct  acagtccca  tgagtactg  1680
tttgatgtg  acagcgata  ggtcaatgt  ttcaagttg  aactggtgg  aaaactgtt  1740
gctgaagac  cagaagcga  gaatccatt  tcagctcag  acactgatt  agacttgga  1800
atgctggct  cctatatcc  aatggatga  gatttccag  tacgttcct  tgatcagtt  1860
tcaccatta  agagcaatt  tccaagccc  ccgagtgtg  gcacagtta  aggattcca  1920
cagacccag  tacagaaac  taccatcac  gtcactgcc  caactgcca  caccgccac  1980
accactgat  aatcaaaag  agtgacgaa  gacaatata  aagacatta  aatactgat  2040
gcatctcca  cttctaccc  agtacctca  gaaatgacc  ctgctaagg  atcagcata  2100
agtggtact  acagtcgga  agcctcacc  gacagagca  gaaagagag  catagaaaa  2160
acagacaaa  ctcatccaa  gagccttaa  ttatctgtc  ctttgaatc  aagaaatac  2220
gttcctgaa  aagaattaa  cccaaggac  atagctttg  agaatgctc  gaggaagcg  2280
aaaatggaa  atgatggct  cctttttca  gcagcagga  ttggaacgt  actgcagca  2340
ccaggtgac  gtgccccta  tatgtcgct  tcttggaaa  gagtgaaag  atacatatc  2400
agtgaacag  atggaatgg  gcagaagac  attttttta  taccctctg  tttagcatg  2460
agactgctg  ggcagtcaa  ggatgagag  ggattacca  agctgacca  ttacgattg  2520
gaagttaat  ctcccatac  aggcagcag  aacctactg  agggtgaag  attactcag  2580
gctttggat  aagttaact  agcttttcc  aatctcact  ctttgattg  taatttttg  2640
gttcagctg  tgttgttgt  tgtggggtt  cgtttctgt  ggttgtttt  gacactggt  2700
gctcactac  t  2711



<210> 10286
<211> 825
<212> PRT
<213> Rattus norvegicus
<308> CAA70701
<400> 10286

Met Glu Gly Ala Gly Gly Glu Asn Glu Lys Lys Lys Met Ser Ser Glu 
  1               5                  10                  15
Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys 
             20                  25                  30
Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His 
         35                  40                  45
Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile 
     50                  55                  60
Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile 
 65                  70                  75                  80
Glu Asp Glu Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Pro 
                 85                  90                  95
Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile 
             100                105                110
Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr 
         115                120                125
Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met 
     130                135                140
Arg Glu Met Leu Thr His Arg Asn Gly Pro Val Arg Lys Gly Lys Glu 
 145                150                155                160
Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                 165                170                175
Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
             180                185                190
His Cys Thr Gly His Ile His Val Tyr Asp Thr Ser Ser Asn Gln Pro 
         195                200                205
Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys 
     210                215                220
Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys 
 225                230                235                240
Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                 245                250                255
Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly 
             260                265                270
Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
         275                280                285
Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln 
     290                295                300
Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln 
 305                310                315                320
Ala Thr Val Ile Tyr Asn Thr Lys Asp Ser Gln Pro Gln Cys Ile Val 
                 325                330                335
Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe 
             340                345                350
Ser Leu Gln Gln Thr Glu Ser Val Leu Lys Pro Val Glu Ser Ser Asp 
         355                360                365
Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser 
     370                375                380
Cys Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu 
 385                390                395                400
Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asp 
                 405                410                415
Asp Thr Glu Thr Glu Asp Gln Gln Leu Glu Asp Val Pro Leu Tyr Asn 
             420                425                430
Asp Val Met Phe Pro Ser Ser Asn Glu Lys Leu Asn Ile Asn Leu Ala 
         435                440                445
Met Ser Pro Leu Pro Ala Ser Glu Thr Pro Lys Pro Leu Arg Ser Ser 
     450                455                460
Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Ser Ser 
 465                470                475                480
Pro Glu Ser Leu Gly Leu Ser Phe Thr Met Pro Gln Ile Gln Asp Gln 
                 485                490                495
Pro Ala Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu Pro 
             500                505                510
Asn Ser Pro Ser Glu Tyr Cys Phe Asp Val Asp Ser Asp Met Val Asn 
         515                520                525
Val Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr Glu 
     530                535                540
Ala Lys Asn Pro Phe Ser Ala Gln Asp Thr Asp Leu Asp Leu Glu Met 
 545                550                555                560
Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser Phe 
                 565                570                575
Asp Gln Leu Ser Pro Leu Glu Ser Asn Ser Pro Ser Pro Pro Ser Val 
             580                585                590
Ser Thr Val Thr Gly Phe Gln Gln Thr Gln Leu Gln Lys Pro Thr Ile 
         595                600                605
Thr Val Thr Ala Ala Thr Ala Thr Thr Ala Thr Thr Thr Asp Glu Ser 
     610                615                620
Lys Ala Val Thr Lys Asp Asn Ile Glu Asp Ile Lys Ile Leu Ile Ala 
 625                630                635                640
Ser Pro Pro Ser Thr Gln Val Pro Gln Glu Met Thr Thr Ala Lys Ala 
                 645                650                655
Ser Ala Tyr Ser Gly Thr His Ser Arg Thr Ala Ser Pro Asp Arg Ala 
             660                665                670
Gly Lys Arg Val Ile Glu Lys Thr Asp Lys Ala His Pro Arg Ser Leu 
         675                680                685
Asn Leu Ser Val Thr Leu Asn Gln Arg Asn Thr Val Pro Glu Glu Glu 
     690                695                700
Leu Asn Pro Arg Thr Ile Ala Leu Gln Asn Ala Gln Arg Lys Arg Lys 
 705                710                715                720
Met Glu His Asp Gly Ser Leu Phe Gln Ala Ala Gly Ile Gly Thr Leu 
                 725                730                735
Leu Gln Gln Pro Gly Asp Arg Ala Pro Thr Met Ser Leu Ser Trp Lys 
             740                745                750
Arg Val Lys Gly Tyr Ile Ser Ser Glu Gln Asp Gly Met Glu Gln Lys 
         755                760                765
Thr Ile Phe Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly Gln 
     770                775                780
Ser Met Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys Glu 
 785                790                795                800
Val Asn Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu Glu 
                 805                810                815
Leu Leu Arg Ala Leu Asp Gln Val Asn 
             820                825



<210> 10287
<211> 3551
<212> DNA
<213> Homo sapiens
<308> AB073325
<400> 10287

gtgaagaca  cgcggggac  gattcacca  ggagggcgc  ggcggcgcg  acgacaaga  60
aaagataag  tctgaacgt  gaaaagaaa  gtctcgaga  gcagccaga  ctcggcgaa  120
taaagaatc  gaagttttt  atgagcttg  tcatcagtt  ccacttcca  ataatgtga  180
ttcgcatct  gataaggcc  ctgtgatga  gcttaccat  agctatttg  gtgtgagga  240
acttctgga  gctggtgat  tggatattg  agatgacat  aaagcacag  tgaattgct  300
ttatttgaa  gccttggat  gttttgtta  ggttctcac  gatgatggt  acatgattt  360
catttctga  aatgtgaac  aatacatgg  attaactca  tttgaacta  ctggacaca  420
tgtgtttga  tttactcat  catgtgacc  tgaggaaat  agagaaatg  ttacacaca  480
aaatggcct  gtgaaaaag  gtaaagaac  aaacacaca  cgaagcttt  ttctcagaa  540
gaagtgtac  ctaactagc  gaggaagaa  tatgaacat  aagtctgca  catggaagg  600
attgcactg  acaggccac  ttcacgtat  tgataccaa  agtaaccaa  ctcagtgtg  660
gtataagaa  ccacctatg  cctgcttgg  gctgatttg  gaacccatt  ctcacccat  720
aaatattga  attccttta  atagcaaga  tttcctcag  cgacacagc  tggatatga  780
attttctta  tgtgatgaa  gaattaccg  attgatggg  tatgagcca  aagaacttt  840
aggccgctc  atttatgaa  attatcatg  tttggactc  gatcatctg  ccaaaactc  900
tcatgatat  tttactaaa  gacaagtca  cacaggaca  tacaggatg  ttgccaaaa  960
aggtggata  gtctgggtt  aaactcaag  aactgtcat  tataacacc  agaattctc  1020
accacagtg  attgtatgt  tgaattacg  tgtgagtgg  attattcag  acgacttga  1080
tttctccct  caacaaaca  aatgtgtcc  taaaccggt  gaatcttca  atatgaaaa  1140
gactcagct  ttcaccaaa  ttgaatcag  agatacaag  agcctcttt  acaaactta  1200
gaaggaacc  gatgcttta  ctttgctgg  cccagccgc  ggagacaca  tcatatctt  1260
agattttgg  agcaacgac  cagaaactg  tgaccagca  cttgaggaa  taccattat  1320
taatgatgt  atgctcccc  cacccaacg  aaaattaca  aatataaat  tggcaatgt  1380
tccattacc  accgctgaa  cgccaaagc  acttcgaag  agtgctgac  ctgcactca  1440
tcaagaagt  gcattaaaa  tagaaccaa  tccagagtc  ctggaactt  cttttacca  1500
gccccagat  caggatcag  cacctagtc  ttccgatgg  agcactaga  aaagttcac  1560
tgagcctaa  agtcccagt  aatattgtt  ttatgtgga  agtgatatg  tcaatgaat  1620
caagttgga  ttggtagaa  aactttttg  tgaagacac  gaagcaaag  acccatttt  1680
tactcagga  acagattta  acttggaga  gttagctcc  tatatccca  tggatgatg  1740
cttccagtt  cgttccttc  atcagttgt  accattaga  agcagttcc  caagccctg  1800
aagcgcaag  cctcaaagc  cagttacag  attccagca  actcaaata  aagaaccta  1860
tgctaatgc  accactacc  ctgccacca  tgatgaatt  aaaacagtg  caaaagacc  1920
tatggaaga  attaaaata  tgattgcat  tccatctcc  acccacata  ataaagaaa  1980
tactagtgc  acatcatca  catatagag  tactcaaag  cggacagcc  caccaaaca  2040
agcaggaaa  ggagtcata  aacagacag  aaaatctca  ccaagaagc  ctaacgtgt  2100
atctgtcgc  ttgagtcaa  gaactacag  tcctgagga  gaactaaat  caaagatac  2160
agctttgca  aatgctcag  gaaagcgaa  aatggaaca  gatggttca  tttttcaag  2220
agtaggaat  atttagcat  tagactgct  gggcaatca  tggatgaaa  tggattacc  2280
cagctgacc  gttatgatt  tgaagttaa  gctcctata  aaggcagca  aaacctact  2340
cagggtgaa  aattactca  agctttgga  caagttaac  gagcttttt  ttaatttca  2400
tcctttttt  ggacactgg  ggctcacta  ctaaagcag  ctatttata  tttctacat  2460
taattttag  agcctggct  caatactgc  caaacttgg  tagttcaat  tttgatccc  2520
tttctactt  atttacatt  atgctcttt  ttagtatgt  ctttaatgc  ggatcacag  2580
cagctcatt  tctcagttt  ttggtattt  aaccattgc  ttgcagtag  atcatttta  2640
aaaatgcac  tttttattt  tttattttt  gctagggag  ttatccctt  ttcgaatta  2700
ttttaagaa  atgccaata  aatttttgt  agaaggcag  aacctttca  catgatcat  2760
ggcagttga  aaattttta  acctttttt  tcacatttt  cataaataa  aatgctttg  2820
cagcagtac  tggtagcca  aattgcaca  tatattttc  taaaaaata  cagcagtta  2880
tcatggaat  tattctgcg  ttataaaac  agtttttaa  aagaaattt  ttttggcct  2940
tgaaattgt  aaacctgga  catgacatt  ttaatcata  aataatgat  cttaaatgc  3000
gtatggttt  ttatttaaa  gggtaaagc  atttacata  tatagaaag  tatgcatat  3060
tctagaagg  atgtggcat  tatttggat  aaattctca  ttcagagaa  tcatctgat  3120
tttctatag  cactttgcc  gctcaaaag  aaacaatac  ctatgtagt  gtggaagtt  3180
atgctaata  tgtgtaact  atattaaac  taaatgttc  gcctaccct  ttggtataa  3240
gatattttg  gcagactgt  aacaagaaa  aaaaaatca  gcattctta  caaaattgc  3300
tagtatgtt  atttgctca  aatacaatg  ttgatttta  gcactttgt  gctattaac  3360
tcctttttt  catgtagat  tcaataatt  agtaatttt  gaagcatta  tttaggaat  3420
tatagttgt  acagtaaat  tcttgtttt  tctatgtac  ttgtacaaa  ttttcattc  3480
ttttgctct  tgtggttgg  tctaacact  actgtattg  tttgttaca  caaataaac  3540
tcttctgtg  a  3551



<210> 10288
<211> 826
<212> PRT
<213> Homo sapiens
<308> Q16665
<400> 10288

Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu 
  1               5                  10                  15
Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys 
             20                  25                  30
Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His 
         35                  40                  45
Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile 
     50                  55                  60
Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile 
 65                  70                  75                  80
Glu Asp Asp Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu 
                 85                  90                  95
Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile 
             100                105                110
Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr 
         115                120                125
Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met 
     130                135                140
Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu 
 145                150                155                160
Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr 
                 165                170                175
Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu 
             180                185                190
His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro 
         195                200                205
Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys 
     210                215                220
Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys 
 225                230                235                240
Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp 
                 245                250                255
Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly 
             260                265                270
Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr 
         275                280                285
Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln 
     290                295                300
Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln 
 305                310                315                320
Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val 
                 325                330                335
Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe 
             340                345                350
Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp 
         355                360                365
Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser 
     370                375                380
Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu 
 385                390                395                400
Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn 
                 405                410                415
Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn 
             420                425                430
Asp Val Met Leu Pro Ser Pro Asn Glu Lys Leu Gln Asn Ile Asn Leu 
         435                440                445
Ala Met Ser Pro Leu Pro Thr Ala Glu Thr Pro Lys Pro Leu Arg Ser 
     450                455                460
Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro 
 465                470                475                480
Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp 
                 485                490                495
Gln Thr Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu 
             500                505                510
Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val 
         515                520                525
Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr 
     530                535                540
Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu 
 545                550                555                560
Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser 
                 565                570                575
Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser 
             580                585                590
Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln 
         595                600                605
Glu Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu 
     610                615                620
Lys Thr Val Thr Lys Asp Arg Met Glu Asp Ile Lys Ile Leu Ile Ala 
 625                630                635                640
Ser Pro Ser Pro Thr His Ile His Lys Glu Thr Thr Ser Ala Thr Ser 
                 645                650                655
Ser Pro Tyr Arg Asp Thr Gln Ser Arg Thr Ala Ser Pro Asn Arg Ala 
             660                665                670
Gly Lys Gly Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro 
         675                680                685
Asn Val Leu Ser Val Ala Leu Ser Gln Arg Thr Thr Val Pro Glu Glu 
     690                695                700
Glu Leu Asn Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg 
 705                710                715                720
Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Gly Thr 
                 725                730                735
Leu Leu Gln Gln Pro Asp Asp His Ala Ala Thr Thr Ser Leu Ser Trp 
             740                745                750
Lys Arg Val Lys Gly Cys Lys Ser Ser Glu Gln Asn Gly Met Glu Gln 
         755                760                765
Lys Thr Ile Ile Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly 
     770                775                780
Gln Ser Met Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys 
 785                790                795                800
Glu Val Asn Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu 
                 805                810                815
Glu Leu Leu Arg Ala Leu Asp Gln Val Asn 
             820                825



<210> 10289
<211> 1457
<212> DNA
<213> Rattus norvegicus
<308> Y12009
<400> 10289

tatttaggt  gatttgtac  gctctccta  caagagaag  tgagacatc  gttccctct  60
caagaaact  tggctcttg  aggatggat  ttcaagggt  gattccaac  tatatctat  120
acatcgatt  tagtatgtc  gcaccctgc  aaaaagtca  tgtgaaaca  attgcagcc  180
agctcctgc  cccactcta  tctctggta  tcatctttg  ttttgtggg  aacatgatg  240
tcttcctca  cctgataag  tgcaaaaag  tgaagagca  gactgatat  tacctgttc  300
acctggcca  ctctgacct  ctcttcctg  tcacactcc  attctgggc  cactatgct  360
caaatgagt  ggtctttgg  aatataatg  gcaaattat  cacagggat  tatcacatt  420
gttatttcg  tggaatctt  ttcattatc  tcctgacaa  tgataggta  ttggctatt  480
tccatgctg  gtttgctat  aaagccaga  cagtcaact  tggggtaat  acaagtgta  540
tcacttggg  ggtggctgt  tttgtctct  tcccagaaa  aatctttat  agatctcaa  600
aagaaggtt  tcattatac  tgcagtcct  attttctac  tattcaata  cgtttctgg  660
agcattttc  aacattaaa  atggtcatc  tgagcctga  cctacccct  cttgtcatg  720
tcatctgct  ctcaggaat  ctcaacacc  tgtttcgct  taggaatga  aagaagagg  780
acagggctg  aaggctcat  tttgccatc  tgattgtct  ctttctctt  tggactccc  840
acaacattg  cctcctcct  accaccttc  aggaatact  tggactgaa  aattgcagt  900
gttctaata  actagacca  gcaatgcag  tgacagaga  tcttgggat  acacactgc  960
gcctcaacc  tgtcatcta  gcctttgtt  gggagaagt  ccggaatta  ctctctgtg  1020
tcttccgaa  acacattgt  aaacgcttc  gcaaacact  ttcaatttt  cagcaagtc  1080
atcctgatc  tgtaagctc  gtctatacc  ggtccacag  agaacagga  gtttctact  1140
gtttatgaa  tggttgagt  ttgtgtatc  cttagtttt  ctatgtagc  tgagggtag  1200
gatggttct  ttagaaaag  aattaatat  gagggccta  ggtacgtgc  ttgttttaa  1260
atttatttg  gatagattg  gtctttgaa  gctgagtag  tttataaac  tgaatgaga  1320
tgtattgat  agacagtaa  ttctggctt  attcctatt  aactacaat  attcccaaa  1380
tcttcttta  ccacaaaag  tcactatta  aaaatactg  gcattggga  aaaaaaaaa  1440
aaaaaaaaa  aaaaaaa  1457



<210> 10290
<211> 354
<212> PRT
<213> Rattus norvegicus
<308> O08556
<400> 10290

Met Asp Phe Gln Gly Ser Ile Pro Thr Tyr Ile Tyr Asp Ile Asp Tyr 
  1               5                  10                  15
Ser Met Ser Ala Pro Cys Gln Lys Val Asn Val Lys Gln Ile Ala Ala 
             20                  25                  30
Gln Leu Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val 
         35                  40                  45
Gly Asn Met Met Val Phe Leu Ile Leu Ile Ser Cys Lys Lys Leu Lys 
     50                  55                  60
Ser Met Thr Asp Ile Tyr Leu Phe Asn Leu Ala Ile Ser Asp Leu Leu 
 65                  70                  75                  80
Phe Leu Leu Thr Leu Pro Phe Trp Ala His Tyr Ala Ala Asn Glu Trp 
                 85                  90                  95
Val Phe Gly Asn Ile Met Cys Lys Leu Phe Thr Gly Ile Tyr His Ile 
             100                105                110
Gly Tyr Phe Gly Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg 
         115                120                125
Tyr Leu Ala Ile Val His Ala Val Phe Ala Ile Lys Ala Arg Thr Val 
     130                135                140
Asn Phe Gly Val Ile Thr Ser Val Val Thr Trp Val Val Ala Val Phe 
 145                150                155                160
Val Ser Leu Pro Glu Ile Ile Phe Met Arg Ser Gln Lys Glu Gly Ser 
                 165                170                175
His Tyr Thr Cys Ser Pro His Phe Leu His Ile Gln Tyr Arg Phe Trp 
             180                185                190
Lys His Phe Gln Thr Leu Lys Met Val Ile Leu Ser Leu Ile Leu Pro 
         195                200                205
Leu Leu Val Met Val Ile Cys Tyr Ser Gly Ile Leu Asn Thr Leu Phe 
     210                215                220
Arg Cys Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe 
 225                230                235                240
Ala Ile Met Ile Val Tyr Phe Leu Phe Trp Thr Pro Tyr Asn Ile Val 
                 245                250                255
Leu Leu Leu Thr Thr Phe Gln Glu Tyr Phe Gly Leu Asn Asn Cys Ser 
             260                265                270
Ser Ser Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly 
         275                280                285
Met Thr His Cys Cys Leu Asn Pro Val Ile Tyr Ala Phe Val Gly Glu 
     290                295                300
Lys Phe Arg Asn Tyr Leu Ser Val Phe Phe Arg Lys His Ile Val Lys 
 305                310                315                320
Arg Phe Cys Lys His Cys Ser Ile Phe Gln Gln Val Asn Pro Asp Arg 
                 325                330                335
Val Ser Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Val Ser Thr 
             340                345                350
Gly Leu 
         355



<210> 10291
<211> 2232
<212> DNA
<213> Homo sapiens
<308> U03882
<400> 10291

ggattgaac  aggacgcat  tccccagta  atccacaac  tgctgtcca  atctcgttc  60
cggtttatc  gaaatacca  cgagagcgg  gaagaagtc  ccacctttt  tgattatga  120
tacggtgct  cctgtcata  atttgacgt  aagcaaatt  gggcccaac  cctgcctcc  180
ctctactcg  tggtgttca  ctttggttt  gtgggcaac  tgctggtcg  cctcatctt  240
ataaactgc  aaaagctga  gtgcttgac  gacatttac  tgctcaacc  ggccatctc  300
gatctgctt  ttcttatta  tctcccatt  tgggctcac  ctgctgcaa  tgagtgggt  360
tttgggaat  caatgtgca  attattcac  gggctgtat  acatcggtt  ttttggcgg  420
atcttcttc  tcatcctcc  gacaatcga  agatacctg  ctattgtcc  tgctgtgtt  480
gctttaaaa  ccaggacgg  cacctttgg  gtggtgaca  gtgtgatca  ctggttggt  540
gctgtgttt  cttctgtcc  aggaatcat  tttactaaa  gccagaaag  agattctgt  600
tatgtctgt  gcccttatt  tccacgagg  tggaataat  tccacacaa  aatgaggaa  660
attttgggg  tggtcctgc  gctgctcat  atggtcatc  gctactcgg  aatcctgaa  720
accctgctt  ggtgtcgaa  cgagaagaa  aggcatagg  cagtgagag  catcttcac  780
atcatgatt  tttactttc  cttctggac  ccctataac  ttgtcattc  cctgaacac  840
ttccaggaa  tcttcggcc  gagtaactg  gaaagcacc  gtcaactgg  ccaagccac  900
caggtgaca  agactcttg  gatgactca  tgctgcatc  atcccatca  ctatgcctt  960
gttggggag  agttcagaa  cctttttca  atagctctt  gctgtagga  tgccccact  1020
caaaaacca  tgtgtggag  tccaggagt  agaccagga  agaatgtga  agtgactac  1080
caaggactc  tcgatggtc  tggaaaagg  aagtcaatt  gcagagccc  tgaagccag  1140
cttcaggac  aagaaggag  ctagagaca  aaatgacag  tctctgctt  ggaaatcac  1200
cgtctggct  cacagatgt  tgattcaca  tgtgaatct  ggtgtctac  ttaccaggc  1260
ggaaggctg  gaggagaga  actccagct  ggttggaaa  cagtatttt  caaactacc  1320
tccagttcc  catttttga  tacaggcat  gagttcaga  tttttttaa  tagtaaaaa  1380
aaaattaaa  ctgaaaact  caacttgta  atgtggtaa  gagttagtt  gagttgcta  1440
catgtcaaa  gtgaaaatg  tgtattagt  acagagata  ttctagctt  gagcttaag  1500
attttgagc  ggtggtatg  ttgggagac  gctgagtca  cccaatagt  gttgattgg  1560
aggagttgg  agtgtgtga  ctgtgggca  attagccta  gtgcatgca  catctaagt  1620
atgatgtcg  ttgaatcac  gtatacgct  catcgctgt  atctcagct  gatctccat  1680
ctctcaggc  tgctgccaa  agccttttg  gttttgttt  gtatcatta  gaagtcatg  1740
gtttaatca  attcgagtg  ttcagtgct  cgcagatgt  cttgatgct  atattgttc  1800
ctaatttgc  agtgggaac  cctaaatca  attggcttc  aatcaaagc  tttaaaccc  1860
attggtaaa  aatggaagg  ggagaagct  cctgaagta  gcaaagact  tcctcttag  1920
cgagccaag  taagaatgt  cttatgttg  ccagtgtgt  tctgatctg  tgcaagcaa  1980
aaacactgg  cttctagaa  caggcaact  gggaactag  ctcccaagc  ggactatgg  2040
tctactttc  ggccacatg  ctaaagaag  tttcagaaa  aagtgggga  agagcagaa  2100
tttcacctt  atatatttg  atgatccta  tgaatgcat  aaatgttaa  ttgatggtg  2160
tgaaatgta  atactgttt  taacaacta  gatttggaa  ataaatcaa  gctataact  2220
tgttgataa  ag  2232



<210> 10292
<211> 374
<212> PRT
<213> Homo sapiens
<308> P41597
<400> 10292

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
  1               5                  10                  15
Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
             20                  25                  30
His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
         35                  40                  45
Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
     50                  55                  60
Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr 
 65                  70                  75                  80
Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro 
                 85                  90                  95
Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
             100                105                110
Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
         115                120                125
Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His 
     130                135                140
Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr 
 145                150                155                160
Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                 165                170                175
Ile Phe Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
             180                185                190
Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile 
         195                200                205
Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
     210                215                220
Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
 225                230                235                240
Ala Val Arg Val Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp 
                 245                250                255
Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe 
             260                265                270
Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln 
         275                280                285
Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile 
     290                295                300
Tyr Ala Phe Val Gly Glu Lys Phe Arg Ser Leu Phe His Ile Ala Leu 
 305                310                315                320
Gly Cys Arg Ile Ala Pro Leu Gln Lys Pro Val Cys Gly Gly Pro Gly 
                 325                330                335
Val Arg Pro Gly Lys Asn Val Lys Val Thr Thr Gln Gly Leu Leu Asp 
             340                345                350
Gly Arg Gly Lys Gly Lys Ser Ile Gly Arg Ala Pro Glu Ala Ser Leu 
         355                360                365
Gln Asp Lys Glu Gly Ala 
     370



<210> 10293
<211> 1457
<212> DNA
<213> Rattus norvegicus
<308> Y12009
<400> 10293

tatttaggt  gatttgtac  gctctccta  caagagaag  tgagacatc  gttccctct  60
caagaaact  tggctcttg  aggatggat  ttcaagggt  gattccaac  tatatctat  120
acatcgatt  tagtatgtc  gcaccctgc  aaaaagtca  tgtgaaaca  attgcagcc  180
agctcctgc  cccactcta  tctctggta  tcatctttg  ttttgtggg  aacatgatg  240
tcttcctca  cctgataag  tgcaaaaag  tgaagagca  gactgatat  tacctgttc  300
acctggcca  ctctgacct  ctcttcctg  tcacactcc  attctgggc  cactatgct  360
caaatgagt  ggtctttgg  aatataatg  gcaaattat  cacagggat  tatcacatt  420
gttatttcg  tggaatctt  ttcattatc  tcctgacaa  tgataggta  ttggctatt  480
tccatgctg  gtttgctat  aaagccaga  cagtcaact  tggggtaat  acaagtgta  540
tcacttggg  ggtggctgt  tttgtctct  tcccagaaa  aatctttat  agatctcaa  600
aagaaggtt  tcattatac  tgcagtcct  attttctac  tattcaata  cgtttctgg  660
agcattttc  aacattaaa  atggtcatc  tgagcctga  cctacccct  cttgtcatg  720
tcatctgct  ctcaggaat  ctcaacacc  tgtttcgct  taggaatga  aagaagagg  780
acagggctg  aaggctcat  tttgccatc  tgattgtct  ctttctctt  tggactccc  840
acaacattg  cctcctcct  accaccttc  aggaatact  tggactgaa  aattgcagt  900
gttctaata  actagacca  gcaatgcag  tgacagaga  tcttgggat  acacactgc  960
gcctcaacc  tgtcatcta  gcctttgtt  gggagaagt  ccggaatta  ctctctgtg  1020
tcttccgaa  acacattgt  aaacgcttc  gcaaacact  ttcaatttt  cagcaagtc  1080
atcctgatc  tgtaagctc  gtctatacc  ggtccacag  agaacagga  gtttctact  1140
gtttatgaa  tggttgagt  ttgtgtatc  cttagtttt  ctatgtagc  tgagggtag  1200
gatggttct  ttagaaaag  aattaatat  gagggccta  ggtacgtgc  ttgttttaa  1260
atttatttg  gatagattg  gtctttgaa  gctgagtag  tttataaac  tgaatgaga  1320
tgtattgat  agacagtaa  ttctggctt  attcctatt  aactacaat  attcccaaa  1380
tcttcttta  ccacaaaag  tcactatta  aaaatactg  gcattggga  aaaaaaaaa  1440
aaaaaaaaa  aaaaaaa  1457



<210> 10294
<211> 354
<212> PRT
<213> Rattus norvegicus
<308> O08556
<400> 10294

Met Asp Phe Gln Gly Ser Ile Pro Thr Tyr Ile Tyr Asp Ile Asp Tyr 
  1               5                  10                  15
Ser Met Ser Ala Pro Cys Gln Lys Val Asn Val Lys Gln Ile Ala Ala 
             20                  25                  30
Gln Leu Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val 
         35                  40                  45
Gly Asn Met Met Val Phe Leu Ile Leu Ile Ser Cys Lys Lys Leu Lys 
     50                  55                  60
Ser Met Thr Asp Ile Tyr Leu Phe Asn Leu Ala Ile Ser Asp Leu Leu 
 65                  70                  75                  80
Phe Leu Leu Thr Leu Pro Phe Trp Ala His Tyr Ala Ala Asn Glu Trp 
                 85                  90                  95
Val Phe Gly Asn Ile Met Cys Lys Leu Phe Thr Gly Ile Tyr His Ile 
             100                105                110
Gly Tyr Phe Gly Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg 
         115                120                125
Tyr Leu Ala Ile Val His Ala Val Phe Ala Ile Lys Ala Arg Thr Val 
     130                135                140
Asn Phe Gly Val Ile Thr Ser Val Val Thr Trp Val Val Ala Val Phe 
 145                150                155                160
Val Ser Leu Pro Glu Ile Ile Phe Met Arg Ser Gln Lys Glu Gly Ser 
                 165                170                175
His Tyr Thr Cys Ser Pro His Phe Leu His Ile Gln Tyr Arg Phe Trp 
             180                185                190
Lys His Phe Gln Thr Leu Lys Met Val Ile Leu Ser Leu Ile Leu Pro 
         195                200                205
Leu Leu Val Met Val Ile Cys Tyr Ser Gly Ile Leu Asn Thr Leu Phe 
     210                215                220
Arg Cys Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe 
 225                230                235                240
Ala Ile Met Ile Val Tyr Phe Leu Phe Trp Thr Pro Tyr Asn Ile Val 
                 245                250                255
Leu Leu Leu Thr Thr Phe Gln Glu Tyr Phe Gly Leu Asn Asn Cys Ser 
             260                265                270
Ser Ser Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly 
         275                280                285
Met Thr His Cys Cys Leu Asn Pro Val Ile Tyr Ala Phe Val Gly Glu 
     290                295                300
Lys Phe Arg Asn Tyr Leu Ser Val Phe Phe Arg Lys His Ile Val Lys 
 305                310                315                320
Arg Phe Cys Lys His Cys Ser Ile Phe Gln Gln Val Asn Pro Asp Arg 
                 325                330                335
Val Ser Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Val Ser Thr 
             340                345                350
Gly Leu 
         355



<210> 10295
<211> 2232
<212> DNA
<213> Homo sapiens
<308> U03882
<400> 10295

ggattgaac  aggacgcat  tccccagta  atccacaac  tgctgtcca  atctcgttc  60
cggtttatc  gaaatacca  cgagagcgg  gaagaagtc  ccacctttt  tgattatga  120
tacggtgct  cctgtcata  atttgacgt  aagcaaatt  gggcccaac  cctgcctcc  180
ctctactcg  tggtgttca  ctttggttt  gtgggcaac  tgctggtcg  cctcatctt  240
ataaactgc  aaaagctga  gtgcttgac  gacatttac  tgctcaacc  ggccatctc  300
gatctgctt  ttcttatta  tctcccatt  tgggctcac  ctgctgcaa  tgagtgggt  360
tttgggaat  caatgtgca  attattcac  gggctgtat  acatcggtt  ttttggcgg  420
atcttcttc  tcatcctcc  gacaatcga  agatacctg  ctattgtcc  tgctgtgtt  480
gctttaaaa  ccaggacgg  cacctttgg  gtggtgaca  gtgtgatca  ctggttggt  540
gctgtgttt  cttctgtcc  aggaatcat  tttactaaa  gccagaaag  agattctgt  600
tatgtctgt  gcccttatt  tccacgagg  tggaataat  tccacacaa  aatgaggaa  660
attttgggg  tggtcctgc  gctgctcat  atggtcatc  gctactcgg  aatcctgaa  720
accctgctt  ggtgtcgaa  cgagaagaa  aggcatagg  cagtgagag  catcttcac  780
atcatgatt  tttactttc  cttctggac  ccctataac  ttgtcattc  cctgaacac  840
ttccaggaa  tcttcggcc  gagtaactg  gaaagcacc  gtcaactgg  ccaagccac  900
caggtgaca  agactcttg  gatgactca  tgctgcatc  atcccatca  ctatgcctt  960
gttggggag  agttcagaa  cctttttca  atagctctt  gctgtagga  tgccccact  1020
caaaaacca  tgtgtggag  tccaggagt  agaccagga  agaatgtga  agtgactac  1080
caaggactc  tcgatggtc  tggaaaagg  aagtcaatt  gcagagccc  tgaagccag  1140
cttcaggac  aagaaggag  ctagagaca  aaatgacag  tctctgctt  ggaaatcac  1200
cgtctggct  cacagatgt  tgattcaca  tgtgaatct  ggtgtctac  ttaccaggc  1260
ggaaggctg  gaggagaga  actccagct  ggttggaaa  cagtatttt  caaactacc  1320
tccagttcc  catttttga  tacaggcat  gagttcaga  tttttttaa  tagtaaaaa  1380
aaaattaaa  ctgaaaact  caacttgta  atgtggtaa  gagttagtt  gagttgcta  1440
catgtcaaa  gtgaaaatg  tgtattagt  acagagata  ttctagctt  gagcttaag  1500
attttgagc  ggtggtatg  ttgggagac  gctgagtca  cccaatagt  gttgattgg  1560
aggagttgg  agtgtgtga  ctgtgggca  attagccta  gtgcatgca  catctaagt  1620
atgatgtcg  ttgaatcac  gtatacgct  catcgctgt  atctcagct  gatctccat  1680
ctctcaggc  tgctgccaa  agccttttg  gttttgttt  gtatcatta  gaagtcatg  1740
gtttaatca  attcgagtg  ttcagtgct  cgcagatgt  cttgatgct  atattgttc  1800
ctaatttgc  agtgggaac  cctaaatca  attggcttc  aatcaaagc  tttaaaccc  1860
attggtaaa  aatggaagg  ggagaagct  cctgaagta  gcaaagact  tcctcttag  1920
cgagccaag  taagaatgt  cttatgttg  ccagtgtgt  tctgatctg  tgcaagcaa  1980
aaacactgg  cttctagaa  caggcaact  gggaactag  ctcccaagc  ggactatgg  2040
tctactttc  ggccacatg  ctaaagaag  tttcagaaa  aagtgggga  agagcagaa  2100
tttcacctt  atatatttg  atgatccta  tgaatgcat  aaatgttaa  ttgatggtg  2160
tgaaatgta  atactgttt  taacaacta  gatttggaa  ataaatcaa  gctataact  2220
tgttgataa  ag  2232



<210> 10296
<211> 374
<212> PRT
<213> Homo sapiens
<308> P41597
<400> 10296

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
  1               5                  10                  15
Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
             20                  25                  30
His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
         35                  40                  45
Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
     50                  55                  60
Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr 
 65                  70                  75                  80
Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro 
                 85                  90                  95
Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
             100                105                110
Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
         115                120                125
Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His 
     130                135                140
Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr 
 145                150                155                160
Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                 165                170                175
Ile Phe Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
             180                185                190
Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile 
         195                200                205
Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
     210                215                220
Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
 225                230                235                240
Ala Val Arg Val Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp 
                 245                250                255
Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe 
             260                265                270
Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln 
         275                280                285
Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile 
     290                295                300
Tyr Ala Phe Val Gly Glu Lys Phe Arg Ser Leu Phe His Ile Ala Leu 
 305                310                315                320
Gly Cys Arg Ile Ala Pro Leu Gln Lys Pro Val Cys Gly Gly Pro Gly 
                 325                330                335
Val Arg Pro Gly Lys Asn Val Lys Val Thr Thr Gln Gly Leu Leu Asp 
             340                345                350
Gly Arg Gly Lys Gly Lys Ser Ile Gly Arg Ala Pro Glu Ala Ser Leu 
         355                360                365
Gln Asp Lys Glu Gly Ala 
     370



<210> 10297
<211> 845
<212> DNA
<213> Rattus norvegicus
<308> Y12517
<400> 10297

aggaagtta  ccgcagaat  ccagatagc  gccgagagg  actcggatc  aatggcgac  60
ccagaggcc  gcggcagcg  caggaatgg  cagggctcc  accccgccg  cacctacta  120
cggctggag  aggtggcga  gcgaaatac  gcggaggag  cgtggatgg  gatccacgg  180
cgagtctac  atatcaccc  cttcctcag  gagcatcct  gtggagaag  ggttctact  240
gaacaagct  gtgccgatg  aactgaaag  tttgaagat  tcggccact  ccctgatgc  300
agggagatg  taaagcagt  ctacattgg  gatgtccat  cgaatgacc  taaacctaa  360
gatggtgac  aggaccctt  aaaaaacaa  tcatgccaa  gttcctggg  atattggat  420
gtccccatc  tgggtgcta  tcttatagg  ttcctgtat  gtcacttct  ggctgacag  480
aaatcctcc  gaggagtcc  cgttgaagt  tcggagcac  tctcctggg  gtgagaggg  540
ggagacttg  gtggaggag  ctgcagggt  ctccttcct  ggatcctgc  agttgtttt  600
tttcccctt  gagccaaga  ggttgacca  atatctatc  tccttcaat  caggaccag  660
atctgtcca  cagcctgag  ctgacgccc  aagcacctg  tcacgttgt  tccttgtca  720
ggtttcttc  cactggttc  cagtcattc  cttcatttc  acagttgat  ccaatgact  780
agagttcct  tgttgtagt  acatttcct  tggggacag  acatgattt  tgatacttt  840
aattc  845



<210> 10298
<211> 146
<212> PRT
<213> Rattus norvegicus
<308> P04166
<400> 10298

Met Ala Thr Pro Glu Ala Ser Gly Ser Gly Arg Asn Gly Gln Gly Ser 
  1               5                  10                  15
Asp Pro Ala Val Thr Tyr Tyr Arg Leu Glu Glu Val Ala Lys Arg Asn 
             20                  25                  30
Thr Ala Glu Glu Thr Trp Met Val Ile His Gly Arg Val Tyr Asp Ile 
         35                  40                  45
Thr Arg Phe Leu Ser Glu His Pro Gly Gly Glu Glu Val Leu Leu Glu 
     50                  55                  60
Gln Ala Gly Ala Asp Ala Thr Glu Ser Phe Glu Asp Val Gly His Ser 
 65                  70                  75                  80
Pro Asp Ala Arg Glu Met Leu Lys Gln Tyr Tyr Ile Gly Asp Val His 
                 85                  90                  95
Pro Asn Asp Leu Lys Pro Lys Asp Gly Asp Lys Asp Pro Ser Lys Asn 
             100                105                110
Asn Ser Cys Gln Ser Ser Trp Ala Tyr Trp Ile Val Pro Ile Val Gly 
         115                120                125
Ala Ile Leu Ile Gly Phe Leu Tyr Arg His Phe Trp Ala Asp Ser Lys 
     130                135                140
Ser Ser 
 145



<210> 10299
<211> 749
<212> DNA
<213> Homo sapiens
<308> AB009282
<400> 10299

ctgcagccc  ggggatccg  ggccttatg  gccctggtt  cggaagccg  ggaaggctg  60
gcgcgggct  tcaaggaaa  tagtcgcgg  atctcagtt  gcggtggag  ggcagtatg  120
ccggttcaa  ggcgactgc  gaagctagc  gcagcgatg  gaaagggca  gaagtcgag  180
cctcagtca  ctattaccg  ttggaggag  tggcaaagc  caactcctt  aaggaactg  240
ggcttgtga  ccatgggcg  gtctacgat  tcacccgct  cctcaacga  caccctgga  300
gagaagagg  tctgctgga  caagctggt  tagatgcaa  tgaaagctt  gaagatgta  360
gacactctt  tgatgccag  gaaatgcta  agcagtact  cattggtga  atccatccg  420
gtgacctta  acctgaaag  ggtagcaag  acccttccc  aaatgatac  tgcaaaagt  480
gctgggcat  ttggatttt  cccatcata  gcgctgttc  cttaggttt  ctgtaccgc  540
actacacat  ggaaagcaa  tcctcctga  gaagccctt  ctgaagtta  aaagtgcat  600
cactttggg  cgaaaacta  agacttgct  gggggctgc  gaagtgccc  ctcctcgaa  660
cctgccagt  gcattcttc  cccttggag  caagacgat  ggccagaca  cacctcaga  720
ctgagacca  cgtcttcca  ctcctcaga  749



<210> 10300
<211> 146
<212> PRT
<213> Homo sapiens
<308> O43169
<400> 10300

Met Ala Thr Ala Glu Ala Ser Gly Ser Asp Gly Lys Gly Gln Glu Val 
  1               5                  10                  15
Glu Thr Ser Val Thr Tyr Tyr Arg Leu Glu Glu Val Ala Lys Arg Asn 
             20                  25                  30
Ser Leu Lys Glu Leu Trp Leu Val Ile His Gly Arg Val Tyr Asp Val 
         35                  40                  45
Thr Arg Phe Leu Asn Glu His Pro Gly Gly Glu Glu Val Leu Leu Glu 
     50                  55                  60
Gln Ala Gly Val Asp Ala Ser Glu Ser Phe Glu Asp Val Gly His Ser 
 65                  70                  75                  80
Ser Asp Ala Arg Glu Met Leu Lys Gln Tyr Tyr Ile Gly Asp Ile His 
                 85                  90                  95
Pro Ser Asp Leu Lys Pro Glu Ser Gly Ser Lys Asp Pro Ser Gln Asn 
             100                105                110
Asp Thr Cys Lys Ser Cys Trp Ala Tyr Trp Ile Leu Pro Ile Ile Gly 
         115                120                125
Ala Val Leu Leu Gly Phe Leu Tyr Arg Tyr Tyr Thr Ser Glu Ser Lys 
     130                135                140
Ser Ser 
 145



<210> 10301
<211> 1614
<212> DNA
<213> Rattus norvegicus
<308> Y12635
<400> 10301

cgggccagc  caagatggc  ttgcgagcg  tgcggggaa  cgtgaacgg  gccgcgccc  60
agctgcccg  gcccaccgg  gggccgatg  ccggagctc  ggagcaggc  ctggcggtg  120
gccggaact  cctctccca  cctcgtctc  cctacaaga  tgtctctgg  gtgaatggt  180
cactagtga  cttagatca  gtaaagttt  ccagatatg  tgagattgt  cacttgaca  240
taccagatg  cacaaaaag  agtgggcaa  ttctagaag  tagtggctc  aaagctgtg  300
ttcaggtat  tgaaggaac  tccggcata  atgccaaga  aacatcctg  gagtttact  360
gagatattc  ccgcacacc  gtgtctgag  atatgcttg  tcgagtatt  aatggatca  420
gaaaaccca  tgaccgagg  cctgtggtg  tggccgaag  cttccttga  atcatgggt  480
agccaatca  ccctcagtg  cgcatctac  cagaagaga  gattcagac  ggcatttct  540
ccatcgacg  catgaacag  attgcgagg  gacagaaaa  ccccatctt  tctgctgcc  600
ggttaccac  caacgagat  gcagctcag  tctgtcgcc  ggctggttt  gtaaagaaa  660
ccaaagacg  ggtagacta  agtgaagaa  actttgcca  tgtgtttgc  gctatggga  720
taaacatgg  aacagcccg  ttcttcaaa  ctgactttg  agaaaatgg  tcaatggac  780
atgtctgcc  tttcttgaa  ctggctaat  acccaacta  cgagaggat  atcactcct  840
gcctggctc  gaccaccgc  gagtttctg  cttaccagt  tgagaagca  gtcctggtc  900
tcctgacag  tatgagttc  tacgctgaa  cacttcgag  ggtttcagc  gccagggaa  960
aggttcctg  tcggcgagg  ttccccggc  acatgtata  ggatttagc  accatctat  1020
aacgcgctg  gcgagtgga  ggtagaaat  gctctatta  ccaaatccc  attctcacc  1080
tgcccaatg  tgatatcac  catcctatc  ctgacttga  tgggtatat  actgagggc  1140
agatctatg  ggacagaca  ctgcacaac  gacagattt  ccctcctat  aatgtgctg  1200
cctcactct  tcggttaat  aagtcagct  ttggagaag  aatgaccag  aaggatcat  1260
ctgatgtgt  taaccagtt  tacgcatgc  atgctatcg  taaggatgt  caagccatg  1320
aagctgtgg  gggagaaga  gccctgacc  cagatgacc  cctttactt  gaatttctg  1380
agaagtttg  gaaaaactt  attactcag  gtccctatg  aaatcgaac  gtctatgag  1440
ctttggaca  tggctggca  ttgcttcga  tcttcccca  agaaatgct  aagaggatc  1500
ctcagagta  cctgagcga  ttttaccct  gagactctg  aaagcacta  ctgctgctg  1560
ttgtgcggc  cgaccctct  gtgaagtgc  ggttctgtt  cctgattcc  tttg  1614



<210> 10302
<211> 511
<212> PRT
<213> Rattus norvegicus
<308> P50517
<400> 10302

Met Ala Leu Arg Ala Met Arg Gly Ile Val Asn Gly Ala Ala Pro Glu 
  1               5                  10                  15
Leu Pro Val Pro Thr Gly Gly Pro Met Ala Gly Ala Arg Glu Gln Ala 
             20                  25                  30
Leu Ala Val Ser Arg Asn Tyr Leu Ser Gln Pro Arg Leu Thr Tyr Lys 
         35                  40                  45
Thr Val Ser Gly Val Asn Gly Pro Leu Val Ile Leu Asp His Val Lys 
     50                  55                  60
Phe Pro Arg Tyr Ala Glu Ile Val His Leu Thr Leu Pro Asp Gly Thr 
 65                  70                  75                  80
Lys Arg Ser Gly Gln Val Leu Glu Val Ser Gly Ser Lys Ala Val Val 
                 85                  90                  95
Gln Val Phe Glu Gly Thr Ser Gly Ile Asp Ala Lys Lys Thr Ser Cys 
             100                105                110
Glu Phe Thr Gly Asp Ile Leu Arg Thr Pro Val Ser Glu Asp Met Leu 
         115                120                125
Gly Arg Val Phe Asn Gly Ser Gly Lys Pro Ile Asp Arg Gly Pro Val 
     130                135                140
Val Leu Ala Glu Asp Phe Leu Asp Ile Met Gly Gln Pro Ile Asn Pro 
 145                150                155                160
Gln Cys Arg Ile Tyr Pro Glu Glu Met Ile Gln Thr Gly Ile Ser Ala 
                 165                170                175
Ile Asp Gly Met Asn Ser Ile Ala Arg Gly Gln Lys Ile Pro Ile Phe 
             180                185                190
Ser Ala Ala Gly Leu Pro His Asn Glu Ile Ala Ala Gln Ile Cys Arg 
         195                200                205
Gln Ala Gly Leu Val Lys Lys Ser Lys Asp Val Val Asp Tyr Ser Glu 
     210                215                220
Glu Asn Phe Ala Ile Val Phe Ala Ala Met Gly Val Asn Met Glu Thr 
 225                230                235                240
Ala Arg Phe Phe Lys Ser Asp Phe Glu Glu Asn Gly Ser Met Asp Asn 
                 245                250                255
Val Cys Leu Phe Leu Asn Leu Ala Asn Asp Pro Thr Ile Glu Arg Ile 
             260                265                270
Ile Thr Pro Arg Leu Ala Leu Thr Thr Ala Glu Phe Leu Ala Tyr Gln 
         275                280                285
Cys Glu Lys His Val Leu Val Ile Leu Thr Asp Met Ser Ser Tyr Ala 
     290                295                300
Glu Ala Leu Arg Glu Val Ser Ala Ala Arg Glu Glu Val Pro Gly Arg 
 305                310                315                320
Arg Gly Phe Pro Gly Tyr Met Tyr Thr Asp Leu Ala Thr Ile Tyr Glu 
                 325                330                335
Arg Ala Gly Arg Val Glu Gly Arg Asn Gly Ser Ile Thr Gln Ile Pro 
             340                345                350
Ile Leu Thr Met Pro Asn Asp Asp Ile Thr His Pro Ile Pro Asp Leu 
         355                360                365
Thr Gly Tyr Ile Thr Glu Gly Gln Ile Tyr Val Asp Arg Gln Leu His 
     370                375                380
Asn Arg Gln Ile Tyr Pro Pro Ile Asn Val Leu Pro Ser Leu Ser Arg 
 385                390                395                400
Leu Met Lys Ser Ala Ile Gly Glu Gly Met Thr Arg Lys Asp His Ala 
                 405                410                415
Asp Val Ser Asn Gln Leu Tyr Ala Cys Tyr Ala Ile Gly Lys Asp Val 
             420                425                430
Gln Ala Met Lys Ala Val Val Gly Glu Glu Ala Leu Thr Ser Asp Asp 
         435                440                445
Leu Leu Tyr Leu Glu Phe Leu Gln Lys Phe Glu Lys Asn Phe Ile Thr 
     450                455                460
Gln Gly Pro Tyr Glu Asn Arg Thr Val Tyr Glu Thr Leu Asp Ile Gly 
 465                470                475                480
Trp Gln Leu Leu Arg Ile Phe Pro Lys Glu Met Leu Lys Arg Ile Pro 
                 485                490                495
Gln Ser Thr Leu Ser Glu Phe Tyr Pro Arg Asp Ser Ala Lys His 
             500                505                510



<210> 10303
<211> 2858
<212> DNA
<213> Homo sapiens
<308> BC003100
<400> 10303

ggacagagg  gacaagatg  cgctgcggg  gatgcgggg  attgtcaac  gggccgcac  60
cgagctacc  gtgcccacc  gtgggccgg  ggtgggagc  cgggagcag  cgctggcag  120
cagtcggaa  tacctctcc  agcctcgcc  cacatacaa  acagtatct  gagtcaatg  180
tccactagt  atcttagat  atgttaagt  tcccaggta  gctgaaatt  tccatttga  240
cttaccgga  ggcacaaag  gaagtgggc  agttctgga  gttagtggt  ccaaggcag  300
agttcaggt  tttgaaggg  cttcaggta  agatgctaa  aaaacgtcc  gtgagttta  360
tggggatat  ctccgaaca  cggtgtctg  ggatatgct  ggtcgggta  tcaatggat  420
gggaaaacc  attgacaga  gtcctgttg  actggccga  gacttcctt  atatcatgg  480
tcagccaat  aaccctcaa  gtcgaatct  cccagagga  atgattcag  ctggcattt  540
ggccatcga  gggatgaac  gtattgcta  ggggcagaa  attcctatc  tctctgctg  600
tgggctacc  cacaatgag  ttgcagctc  gatctgtcg  caggctggt  tggtaaaga  660
atccaaaga  gtagtagac  acagtgagg  aaattttgc  attgtattt  ctgctatgg  720
tgtaaacat  gaaactgcc  ggttcttca  atctgactt  gaagaaaat  gctcaatgg  780
caatgtctg  ctctttttg  acttggcta  tgacccaac  attgagcga  ttatcactc  840
tcgcctggc  ctaaccaca  ctgaatttc  ggcgtacca  tgtgagaaa  atgtattgg  900
tattctaac  gacatgagt  cttatgctg  agcacttcg  gaggtttca  cagccaggg  960
agaggtacc  ggtcgacga  gttttccag  ttacatgta  acagattta  ccacgatat  1020
tgaacgcgc  gggcgagtg  aagggagaa  cggctcgat  actcaaatc  ctattctaa  1080
catgcctaa  gatgatatc  ctcacccca  cccagactt  actggctac  ttacagagg  1140
gcagatcta  gtggacaga  agctgcaca  cagacagat  tatccacct  tcaatgtgc  1200
gccctcact  tcacggtta  tgaagtctg  tattggaga  gggatgacc  ggaaggatc  1260
tgccgatgt  tctaaccag  tatatgcgt  ctatgctat  ggaaaggat  tgcaagcca  1320
gaaagctgt  gttggagaa  aagccctta  ctcagatga  cttctctac  tggaatttc  1380
gcagaagtt  gagaggaac  tcattgctc  gggtcctta  gaaaatcgc  ctgtctttg  1440
gactttgga  attggctgg  agctactcc  aatcttccc  aaagaaatg  tgaagagaa  1500
ccctcagag  accctcagc  aattttacc  tcgagactc  gcaaagcat  agctgctgc  1560
tctgcattg  tccgcgctc  tgtgaaata  tggttctgt  ttctttatt  cttttgcac  1620
ctcggttcc  acctttgtg  tggagttta  catgttacc  tgtaattaa  aacaaagaa  1680
aggtaacat  ttgtgccag  gttgcaacg  tttaaactg  taacagacc  taaaatatc  1740
ccctacctg  gtcctcagt  ctatgttta  agtgctgca  ggatggagt  gcgttttct  1800
attgctgta  gtattgtac  tagtggagt  gttagttac  tgataacag  cttgttatt  1860
gggtctctt  gaccttacc  ctcaactcc  tcaagagta  cagtctctg  agttataat  1920
ctttggtct  tacattagg  gcaagatcc  gtctgagag  agtctcctt  gagaagggc  1980
aagaggctc  ttcctgagt  tttgctttc  gtttgttgg  atgcctgta  tgctgggct  2040
tgctgctgc  cgaagcaga  ggttttgac  gtctttttg  tctttccta  ataatgaat  2100
gatgagtga  aggagtttt  tttttctct  tagtactta  gtattggga  tcctgtgtc  2160
tacagctct  cctctccaa  taatacaca  aatcctgca  ctttttgca  agctggtat  2220
tgtctggta  cagtgagac  ccttgtctt  gtgatcctt  ctgggtttc  aagcagagg  2280
gtcacatga  tacaattgc  agtagagtt  ttgtttggg  tacaagatg  gaagaaaga  2340
aaacctaca  cctttctac  ttctgacat  ctaacagtg  tttaagttt  taaagtgtt  2400
accagatgc  gaaggcaag  ggagggagc  gaagcactt  tgtttacgg  tattttaaa  2460
tctgttaga  agcagcctt  gaaaatccc  aatttggtt  tgctttttg  cctctctct  2520
ccttttcag  gtaatcttt  tggcacaaa  gatagcatt  ccaagcttt  gagttttct  2580
aattcctgc  ccttcctga  gtgagccct  agcgatctt  tatgcagtt  tgccatgcg  2640
cctgttggt  tctctgtgt  ctttgttac  tgggtgcaa  agcaacttc  ctaccccgt  2700
cattccatc  ttcatgttg  gtaaagttc  tcacttttt  ctctgaggg  tgggggttg  2760
gggagtcag  atgattata  tttaatgta  aaaatgtga  atctggata  aaaatgaaa  2820
taaatgtta  attaaatgg  aaaaaaaaa  aaaaaaaa  2858



<210> 10304
<211> 511
<212> PRT
<213> Homo sapiens
<308> P21281
<400> 10304

Met Ala Leu Arg Ala Met Arg Gly Ile Val Asn Gly Ala Ala Pro Glu 
  1               5                  10                  15
Leu Pro Val Pro Thr Gly Gly Pro Ala Val Gly Ala Arg Glu Gln Ala 
             20                  25                  30
Leu Ala Val Ser Arg Asn Tyr Leu Ser Gln Pro Arg Leu Thr Tyr Lys 
         35                  40                  45
Thr Val Ser Gly Val Asn Gly Pro Leu Val Ile Leu Asp His Val Lys 
     50                  55                  60
Phe Pro Arg Tyr Ala Glu Ile Val His Leu Thr Leu Pro Asp Gly Thr 
 65                  70                  75                  80
Lys Arg Ser Gly Gln Val Leu Glu Val Ser Gly Ser Lys Ala Val Val 
                 85                  90                  95
Gln Val Phe Glu Gly Thr Ser Gly Ile Asp Ala Lys Lys Thr Ser Cys 
             100                105                110
Glu Phe Thr Gly Asp Ile Leu Arg Thr Pro Val Ser Glu Asp Met Leu 
         115                120                125
Gly Arg Val Phe Asn Gly Ser Gly Lys Pro Ile Asp Arg Gly Pro Val 
     130                135                140
Val Leu Ala Glu Asp Phe Leu Asp Ile Met Gly Gln Pro Ile Asn Pro 
 145                150                155                160
Gln Cys Arg Ile Tyr Pro Glu Glu Met Ile Gln Thr Gly Ile Ser Ala 
                 165                170                175
Ile Asp Gly Met Asn Ser Ile Ala Arg Gly Gln Lys Ile Pro Ile Phe 
             180                185                190
Ser Ala Ala Gly Leu Pro His Asn Glu Ile Ala Ala Gln Ile Cys Arg 
         195                200                205
Gln Ala Gly Leu Val Lys Lys Ser Lys Asp Val Val Asp Tyr Ser Glu 
     210                215                220
Glu Asn Phe Ala Ile Val Phe Ala Ala Met Gly Val Asn Met Glu Thr 
 225                230                235                240
Ala Arg Phe Phe Lys Ser Asp Phe Glu Glu Asn Gly Ser Met Asp Asn 
                 245                250                255
Val Cys Leu Phe Leu Asn Leu Ala Asn Asp Pro Thr Ile Glu Arg Ile 
             260                265                270
Ile Thr Pro Arg Leu Ala Leu Thr Thr Ala Glu Phe Leu Ala Tyr Gln 
         275                280                285
Cys Glu Lys His Val Leu Val Ile Leu Thr Asp Met Ser Ser Tyr Ala 
     290                295                300
Glu Ala Leu Arg Glu Val Ser Ala Ala Arg Glu Glu Val Pro Gly Arg 
 305                310                315                320
Arg Gly Phe Pro Gly Tyr Met Tyr Thr Asp Leu Ala Thr Ile Tyr Glu 
                 325                330                335
Arg Ala Gly Arg Val Glu Gly Arg Asn Gly Ser Ile Thr Gln Ile Pro 
             340                345                350
Ile Leu Thr Met Pro Asn Asp Asp Ile Thr His Pro Ile Pro Asp Leu 
         355                360                365
Thr Gly Tyr Ile Thr Glu Gly Gln Ile Tyr Val Asp Arg Gln Leu His 
     370                375                380
Asn Arg Gln Ile Tyr Pro Pro Ile Asn Val Leu Pro Ser Leu Ser Arg 
 385                390                395                400
Leu Met Lys Ser Ala Ile Gly Glu Gly Met Thr Arg Lys Asp His Ala 
                 405                410                415
Asp Val Ser Asn Gln Leu Tyr Ala Cys Tyr Ala Ile Gly Lys Asp Val 
             420                425                430
Gln Ala Met Lys Ala Val Val Gly Glu Glu Ala Leu Thr Ser Asp Asp 
         435                440                445
Leu Leu Tyr Leu Glu Phe Leu Gln Lys Phe Glu Arg Asn Phe Ile Ala 
     450                455                460
Gln Gly Pro Tyr Glu Asn Arg Thr Val Phe Glu Thr Leu Asp Ile Gly 
 465                470                475                480
Trp Gln Leu Leu Arg Ile Phe Pro Lys Glu Met Leu Lys Arg Ile Pro 
                 485                490                495
Gln Ser Thr Leu Ser Glu Phe Tyr Pro Arg Asp Ser Ala Lys His 
             500                505                510



<210> 10305
<211> 1182
<212> DNA
<213> Rattus norvegicus
<308> Y13275
<400> 10305

acttgcctg  agataacgt  tgggatatt  aaaggtgtg  gttaatttt  tatccattt  60
agtaactgg  ttttttttt  ttctttccg  ctacttcct  gctttctat  gctacccga  120
gctgcaggc  cacggatct  tgcaggcaa  atccctcag  gccttcgca  gacagcctg  180
taacgactg  ttcgtccta  tgtaactgg  tggctgccc  ttctccgaa  tggcaggtg  240
cagtggctg  ttaaagtat  cgatgtttt  cttcaactt  ttgttctgg  tatgtggta  300
actgatcct  ggtctagcc  tatggttga  agtaagcaa  gacggcaaa  agattatca  360
atccggtga  aatggcacg  accccttca  tgctgtgaa  atcttgatt  cagttgggt  420
catcatcat  gttctgggt  tcctgggat  ctgcggagc  gtgaaagaa  gtcgctgca  480
gcttctctt  ttttttatc  gcttgctcc  gattctgct  ctgcaagta  ccgcaggta  540
cctaggagc  actttcaaa  ctgaatcta  ccgcattct  aatgaaacg  tctatgaaa  600
tgccaagct  ttgtcagaa  caagcaatg  ggcaaaaga  gtacagaag  ccatgattg  660
atttcagtc  gagtttaag  gctgtggct  gagatttgg  gctgctgac  ggggaaaaa  720
ttttccaga  gcgaaagag  catgccaat  tacaggatc  gattgtgaa  gttataatg  780
agagaatgt  tatcgaacg  cctgtcttt  tctgataaa  gagctggtt  aaaaaaaca  840
tattattgt  attggaatt  cctttggac  ggcagttat  gagattctt  gtttggtgt  900
ttctatggt  ctctactgc  aaattggaa  caaatgaat  tgcggactt  ctcagtcgt  960
atagacacc  tttaagttt  tgctttggc  tcgtaactt  aaatactcg  gtactgtac  1020
taccaggag  agatgtctt  ttgatgagc  ctcacttag  cagactaca  gtatcttca  1080
atgtactca  ctcatttaa  tgtgaagga  ataataaaa  tggtcgtgt  ttttttttt  1140
tcacaataa  aagtgttcg  gctgaaaaa  aaaaaaaaa  aa  1182



<210> 10306
<211> 235
<212> PRT
<213> Rattus norvegicus
<308> CAA73724
<400> 10306

Met Ala Gly Val Ser Gly Cys Leu Lys Tyr Ser Met Phe Phe Phe Asn 
  1               5                  10                  15
Phe Leu Phe Trp Val Cys Gly Thr Leu Ile Leu Gly Leu Ala Ile Trp 
             20                  25                  30
Leu Arg Val Ser Lys Asp Gly Lys Glu Ile Ile Thr Ser Gly Asp Asn 
         35                  40                  45
Gly Thr Asn Pro Phe Ile Ala Val Asn Ile Leu Ile Ala Val Gly Ser 
     50                  55                  60
Ile Ile Met Val Leu Gly Phe Leu Gly Cys Cys Gly Ala Val Lys Glu 
 65                  70                  75                  80
Ser Arg Cys Met Leu Leu Leu Phe Phe Ile Gly Leu Leu Leu Ile Leu 
                 85                  90                  95
Leu Leu Gln Val Ala Ala Gly Ile Leu Gly Ala Thr Phe Lys Ser Glu 
             100                105                110
Ser Ser Arg Ile Leu Asn Glu Thr Leu Tyr Glu Asn Ala Lys Leu Leu 
         115                120                125
Ser Glu Thr Ser Asn Glu Ala Lys Glu Val Gln Lys Ala Met Ile Ala 
     130                135                140
Phe Gln Ser Glu Phe Lys Cys Cys Gly Leu Arg Phe Gly Ala Ala Asp 
 145                150                155                160
Trp Gly Lys Asn Phe Pro Asp Ala Lys Glu Ser Cys Gln Cys Thr Gly 
                 165                170                175
Ser Asp Cys Glu Ser Tyr Asn Gly Glu Asn Val Tyr Arg Thr Thr Cys 
             180                185                190
Leu Ser Leu Ile Lys Glu Leu Val Glu Lys Asn Ile Ile Ile Val Ile 
         195                200                205
Gly Ile Ala Phe Gly Leu Ala Val Ile Glu Ile Leu Gly Leu Val Phe 
     210                215                220
Ser Met Val Leu Tyr Cys Gln Ile Gly Ser Lys 
 225                230                235



<210> 10307
<211> 1159
<212> DNA
<213> Homo sapiens
<308> BC005246
<400> 10307

agtgcccca  gagctatga  aagcaaagg  acatacttg  ctggagata  cctttgcga  60
atttaaatg  ccgtggata  agaaatctc  gcaggcaag  tgctccaga  catattgca  120
gacaagcct  taacgaata  ttaaattca  ggcatctgg  ttcctaatc  ttttccgaa  180
tggcaggtg  gagtgcctg  ataaaatat  ctatgttta  cttcaactt  ttgttctgg  240
tatgtggta  cttgatcct  gcattagca  tatgggtac  aataagcaa  gactctcaa  300
caatttttg  ttctgaaga  gtaggctct  gctcctacg  tgctgtgga  atattgatt  360
ctgtaggtg  catcatcat  attctgggc  tcctggcat  ctgcggtgc  ataaaagaa  420
gtcgctgca  gcttctgtt  tttttcata  gcttgcttc  gatcctgct  ctgcaggtg  480
cgacaggta  cctaggagc  gttttcaaa  ctaagtctg  tcgcattgt  aatgaaact  540
tctatgaaa  cacaaagct  ttgagcgcc  caggggaaa  tgaaaaaca  ttccaggaa  600
ccataattg  gtttcaaga  gagtttaaa  gctgcggtt  ggtcaatgg  gctgctgat  660
ggggaaata  ttttcaaca  tatcctgaa  tatgtgcct  tctagataa  cagagacca  720
gccaaagct  taatggaaa  caagtttac  aagagacct  tatttcttt  ataaaagac  780
tcttggcaa  aaatttgat  atagttatt  gaatagcat  tggactggc  gttattgag  840
tactgggtt  ggtgttttc  atggtcctg  attgccaga  cgggaacaa  tgaatctgt  900
gatgcatca  gctatcgtc  gtcaaaccc  tttaaaatg  tgctttggc  ttgtaaatt  960
aaatatgta  gtgctatat  agtcaggag  agctgtctt  ttaaaatgt  tcggctagc  1020
agaccacag  tatcttcta  acatattga  cacatttaa  atttgaggg  tataaggga  1080
aatgatatg  atgtgtatt  ttactcaaa  taaaagtaa  tgtttacgc  aaaaaaaaa  1140
aaaaaaaaa  aaaaaaaaa  1159



<210> 10308
<211> 237
<212> PRT
<213> Homo sapiens
<308> P19075
<400> 10308

Met Ala Gly Val Ser Ala Cys Ile Lys Tyr Ser Met Phe Thr Phe Asn 
  1               5                  10                  15
Phe Leu Phe Trp Leu Cys Gly Ile Leu Ile Leu Ala Leu Ala Ile Trp 
             20                  25                  30
Val Arg Val Ser Asn Asp Ser Gln Ala Ile Phe Gly Ser Glu Asp Val 
         35                  40                  45
Gly Ser Ser Ser Tyr Val Ala Val Asp Ile Leu Ile Ala Val Gly Ala 
     50                  55                  60
Ile Ile Met Ile Leu Gly Phe Leu Gly Cys Cys Gly Ala Ile Lys Glu 
 65                  70                  75                  80
Ser Arg Cys Met Leu Leu Leu Phe Phe Ile Gly Leu Leu Leu Ile Leu 
                 85                  90                  95
Leu Leu Gln Val Ala Thr Gly Ile Leu Gly Ala Val Phe Lys Ser Lys 
             100                105                110
Ser Asp Arg Ile Val Asn Glu Thr Leu Tyr Glu Asn Thr Lys Leu Leu 
         115                120                125
Ser Ala Thr Gly Glu Ser Glu Lys Gln Phe Gln Glu Ala Ile Ile Val 
     130                135                140
Phe Gln Glu Glu Phe Lys Cys Cys Gly Leu Val Asn Gly Ala Ala Asp 
 145                150                155                160
Trp Gly Asn Asn Phe Gln His Tyr Pro Glu Leu Cys Ala Cys Leu Asp 
                 165                170                175
Lys Gln Arg Pro Cys Gln Ser Tyr Asn Gly Lys Gln Val Tyr Lys Glu 
             180                185                190
Thr Cys Ile Ser Phe Ile Lys Asp Phe Leu Ala Lys Asn Leu Ile Ile 
         195                200                205
Val Ile Gly Ile Ser Phe Gly Leu Ala Val Ile Glu Ile Leu Gly Leu 
     210                215                220
Val Phe Ser Met Val Leu Tyr Cys Gln Ile Gly Asn Lys 
 225                230                235



<210> 10309
<211> 342
<212> DNA
<213> Rattus norvegicus
<308> Y13336
<400> 10309

atgtcggcg  cggtagtgt  cgtcatctc  cggttcctg  aggagtact  gagctccac  60
ccacagcgg  tgaagttgc  ggatgccta  ctcctttat  tattgctga  cggggcgct  120
cagttcggc  actgtctcc  cgtgggcac  ttccccttc  actctttcc  ctctggctt  180
atctcttgt  tgggcagct  catcttagc  gtttgcttg  gaatacaga  caaccccca  240
aacaaggcg  atttccaag  catctctcc  gagcgagcc  ttgctgatt  tctctttgc  300
agcactatc  tgcacctcg  cgtcatgaa  tttgttggc  ga  342



<210> 10310
<211> 113
<212> PRT
<213> Rattus norvegicus
<308> CAA73780
<400> 10310

Met Ser Ala Ser Val Val Ser Val Ile Ser Arg Phe Leu Glu Glu Tyr 
  1               5                  10                  15
Leu Ser Ser Thr Pro Gln Arg Leu Lys Leu Leu Asp Ala Tyr Leu Leu 
             20                  25                  30
Tyr Ile Leu Leu Thr Gly Ala Leu Gln Phe Gly Tyr Cys Leu Leu Val 
         35                  40                  45
Gly Thr Phe Pro Phe Asn Ser Phe Leu Ser Gly Phe Ile Ser Cys Val 
     50                  55                  60
Gly Ser Phe Ile Leu Ala Val Cys Leu Arg Ile Gln Ile Asn Pro Gln 
 65                  70                  75                  80
Asn Lys Ala Asp Phe Gln Gly Ile Ser Pro Glu Arg Ala Phe Ala Asp 
                 85                  90                  95
Phe Leu Phe Ala Ser Thr Ile Leu His Leu Val Val Met Asn Phe Val 
             100                105                110
Gly 
         115



<210> 10311
<211> 699
<212> DNA
<213> Homo sapiens
<308> NM_001344
<400> 10311

catccggtg  ggtcgacgg  tcctccaag  gtttggggc  cggaccgga  taccttgcg  60
gcagttatg  cggcgtcgg  agtgtctgt  atttcgcgg  tcttagaag  gtacttgag  120
tccactccg  agcgtctga  gttgctgga  gcgtacctg  tgtatatac  gctgaccgg  180
gcgctgcag  tcggttact  tctcctcgt  gggaccttc  ccttcaact  ttttctctc  240
ggcttcatc  cttgtgtgg  gagtttcat  ctagcggtt  gcctgagaa  acagatcaa  300
ccacagaac  aagcggatt  ccaaggcat  tccccagag  gagcctttg  tgattttct  360
tttgccagc  ccatcctgc  ccttgttgt  atgaacttt  ttggctgaa  cattctcat  420
tacttaatt  aggagtagg  gactaaaag  atgttcact  tttgaattt  ctggataag  480
gttctggag  tggcagctt  ttggacaca  ggattttct  cagatttga  acttactgc  540
agctctgct  tttatgaca  gagaaaagc  cagagttca  tgtgtgtca  aacaacttt  600
taacaaaca  ttattaatc  agcctctgc  tttcattaa  tgtaacctt  tgctttcca  660
attaaagaa  tccatgcca  tcctcaaaa  aaaaaaaaa  699



<210> 10312
<211> 113
<212> PRT
<213> Homo sapiens
<308> P46966
<400> 10312

Met Ser Ala Ser Val Val Ser Val Ile Ser Arg Phe Leu Glu Glu Tyr 
  1               5                  10                  15
Leu Ser Ser Thr Pro Gln Arg Leu Lys Leu Leu Asp Ala Tyr Leu Leu 
             20                  25                  30
Tyr Ile Leu Leu Thr Gly Ala Leu Gln Phe Gly Tyr Cys Leu Leu Val 
         35                  40                  45
Gly Thr Phe Pro Phe Asn Ser Phe Leu Ser Gly Phe Ile Ser Cys Val 
     50                  55                  60
Gly Ser Phe Ile Leu Ala Val Cys Leu Arg Ile Gln Ile Asn Pro Gln 
 65                  70                  75                  80
Asn Lys Ala Asp Phe Gln Gly Ile Ser Pro Glu Arg Ala Phe Ala Asp 
                 85                  90                  95
Phe Leu Phe Ala Ser Thr Ile Leu His Leu Val Val Met Asn Phe Val 
             100                105                110
Gly 
         115



<210> 10313
<211> 342
<212> DNA
<213> Rattus norvegicus
<308> Y13336
<400> 10313

atgtcggcg  cggtagtgt  cgtcatctc  cggttcctg  aggagtact  gagctccac  60
ccacagcgg  tgaagttgc  ggatgccta  ctcctttat  tattgctga  cggggcgct  120
cagttcggc  actgtctcc  cgtgggcac  ttccccttc  actctttcc  ctctggctt  180
atctcttgt  tgggcagct  catcttagc  gtttgcttg  gaatacaga  caaccccca  240
aacaaggcg  atttccaag  catctctcc  gagcgagcc  ttgctgatt  tctctttgc  300
agcactatc  tgcacctcg  cgtcatgaa  tttgttggc  ga  342



<210> 10314
<211> 113
<212> PRT
<213> Rattus norvegicus
<308> CAA73780
<400> 10314

Met Ser Ala Ser Val Val Ser Val Ile Ser Arg Phe Leu Glu Glu Tyr 
  1               5                  10                  15
Leu Ser Ser Thr Pro Gln Arg Leu Lys Leu Leu Asp Ala Tyr Leu Leu 
             20                  25                  30
Tyr Ile Leu Leu Thr Gly Ala Leu Gln Phe Gly Tyr Cys Leu Leu Val 
         35                  40                  45
Gly Thr Phe Pro Phe Asn Ser Phe Leu Ser Gly Phe Ile Ser Cys Val 
     50                  55                  60
Gly Ser Phe Ile Leu Ala Val Cys Leu Arg Ile Gln Ile Asn Pro Gln 
 65                  70                  75                  80
Asn Lys Ala Asp Phe Gln Gly Ile Ser Pro Glu Arg Ala Phe Ala Asp 
                 85                  90                  95
Phe Leu Phe Ala Ser Thr Ile Leu His Leu Val Val Met Asn Phe Val 
             100                105                110
Gly 
         115



<210> 10315
<211> 699
<212> DNA
<213> Homo sapiens
<308> NM_001344
<400> 10315

catccggtg  ggtcgacgg  tcctccaag  gtttggggc  cggaccgga  taccttgcg  60
gcagttatg  cggcgtcgg  agtgtctgt  atttcgcgg  tcttagaag  gtacttgag  120
tccactccg  agcgtctga  gttgctgga  gcgtacctg  tgtatatac  gctgaccgg  180
gcgctgcag  tcggttact  tctcctcgt  gggaccttc  ccttcaact  ttttctctc  240
ggcttcatc  cttgtgtgg  gagtttcat  ctagcggtt  gcctgagaa  acagatcaa  300
ccacagaac  aagcggatt  ccaaggcat  tccccagag  gagcctttg  tgattttct  360
tttgccagc  ccatcctgc  ccttgttgt  atgaacttt  ttggctgaa  cattctcat  420
tacttaatt  aggagtagg  gactaaaag  atgttcact  tttgaattt  ctggataag  480
gttctggag  tggcagctt  ttggacaca  ggattttct  cagatttga  acttactgc  540
agctctgct  tttatgaca  gagaaaagc  cagagttca  tgtgtgtca  aacaacttt  600
taacaaaca  ttattaatc  agcctctgc  tttcattaa  tgtaacctt  tgctttcca  660
attaaagaa  tccatgcca  tcctcaaaa  aaaaaaaaa  699



<210> 10316
<211> 113
<212> PRT
<213> Homo sapiens
<308> P46966
<400> 10316

Met Ser Ala Ser Val Val Ser Val Ile Ser Arg Phe Leu Glu Glu Tyr 
  1               5                  10                  15
Leu Ser Ser Thr Pro Gln Arg Leu Lys Leu Leu Asp Ala Tyr Leu Leu 
             20                  25                  30
Tyr Ile Leu Leu Thr Gly Ala Leu Gln Phe Gly Tyr Cys Leu Leu Val 
         35                  40                  45
Gly Thr Phe Pro Phe Asn Ser Phe Leu Ser Gly Phe Ile Ser Cys Val 
     50                  55                  60
Gly Ser Phe Ile Leu Ala Val Cys Leu Arg Ile Gln Ile Asn Pro Gln 
 65                  70                  75                  80
Asn Lys Ala Asp Phe Gln Gly Ile Ser Pro Glu Arg Ala Phe Ala Asp 
                 85                  90                  95
Phe Leu Phe Ala Ser Thr Ile Leu His Leu Val Val Met Asn Phe Val 
             100                105                110
Gly 
         115



<210> 10317
<211> 2052
<212> DNA
<213> Rattus norvegicus
<308> Y13381
<400> 10317

atggccgac  tcaagacgg  catcttcgc  aaaaacgtg  aaaagcggc  caaccgggc  60
caggaaaag  tcctccaga  gctgggaaa  gcagatgaa  caaaagatg  acagtttga  120
gaatatgtt  agaacttca  gcggcaaga  gcagagggt  ccagacttc  gcgagaact  180
cgaggatat  tagcggcaa  caaaggtat  caggaggcc  caatgaagc  taccgagtc  240
ctacatgaa  tctacgagc  agattggta  ggacgggaa  atgtaaaga  ggttggtga  300
aagtgtgat  tgctgtggg  agacttcca  caaaagcta  tggatgggt  cttgctgac  360
ctggacacg  acctgggcc  gtttcctga  ataaagaat  gcatcgcta  gcgcagcag  420
aagctcgtg  attacgaca  tgcccgcca  cacctggag  ctctgcaga  ttccaaaag  480
aaggatgag  gtcggatct  taaggcaga  gaggagttt  agaaagcac  gaaagtgtt  540
gaagagttc  atgttgact  acaagaaga  ttgccatca  tatggtcaa  acgagttgg  600
ttttatgtc  atactttca  aaacgtctc  agccttgag  ccaagtttc  caaggaaat  660
gcagtgctt  gccacaagc  ttatgaagt  atgacgaaa  ttggtgatc  gcacgctga  720
aaggccttc  gcattcaag  agctcccag  gattcgggt  ctcttcgca  tgcaaagac  780
ccatcaccc  cagaggagg  ttcacccct  cccagccca  cggctagtc  caaccacac  840
ttagcacct  catctcctg  cccagtgcg  cccagatca  cttcacaga  aaggaaagg  900
cctcctgtc  cacctctgc  taaagtcac  ccaacaaag  aactacagc  ggagaacat  960
atcaatttc  ttgaggaca  ctttgtacc  gaaatcaat  tgacaacac  ttcccagaa  1020
gaagtcctg  aggtgaaga  ggaggagac  ttgctggat  tggactttg  ccctttcaa  1080
cctgatgtg  ccccagcag  ttctgctgc  gcgacccac  cacccatgt  tcagacatt  1140
ccctgggac  tatggacga  aagcactga  ttggtacaa  cggcttctg  aggttcgtt  1200
aatgatttt  cccagcccc  ggatacttc  ttattcacg  tgcagacag  tcagaatat  1260
gctgaaact  agcaggctc  acctacaga  ccccaggca  aggagcctc  caccactgc  1320
gctgcacct  ctgctgggc  ggaccttgg  ctagagatg  aggagccaa  ggaggaggc  1380
gcgatccct  ctggaactg  tgctggtga  actgtggga  ctgaggggt  cacagggga  1440
gaagcagag  cagagaagg  agccctacc  gctggagaa  gcgaaagtc  tgagggagc  1500
aaaatcgat  tggaaagca  tgagcttgc  agcagtgag  gccctcaag  agcagagct  1560
gaagctggt  ctcctcagg  aaaggtcat  ccttctgtt  tcatagagc  agcctccaa  1620
catgaagga  aagaacacc  agaaaccac  acgggtact  aaacaaggg  ggccactga  1680
gacgtggct  cccagggcc  agccggtga  aagcaggaa  tggctacag  gcccacgcc  1740
ctggattct  aggctgcta  gcctgcacc  gcaggtgct  tggatgctt  gctgtctgc  1800
ggggatgcc  ctcaggaac  gcctcctgg  tttctctac  aggtggaaa  tctgcatga  1860
ttcgaggca  cgaactctg  tgaacttac  ctacaaagg  gtgatgtgg  gctcgtggt  1920
ccctcagac  cagaagccg  ccaggatgc  ggctggttg  tgggggtga  ggagtcaga  1980
tggcttcag  acagagacc  ggccacata  aaaggcctc  ttccagaga  cttcacacg  2040
cacctagaa  ag  2052



<210> 10318
<211> 683
<212> PRT
<213> Rattus norvegicus
<308> O08838
<400> 10318

Met Ala Asp Ile Lys Thr Gly Ile Phe Ala Lys Asn Val Gln Lys Arg 
  1               5                  10                  15
Leu Asn Arg Ala Gln Glu Lys Val Leu Gln Lys Leu Gly Lys Ala Asp 
             20                  25                  30
Glu Thr Lys Asp Glu Gln Phe Glu Glu Tyr Val Gln Asn Phe Lys Arg 
         35                  40                  45
Gln Glu Ala Glu Gly Thr Arg Leu Gln Arg Glu Leu Arg Gly Tyr Leu 
     50                  55                  60
Ala Ala Ile Lys Gly Met Gln Glu Ala Ser Met Lys Leu Thr Glu Ser 
 65                  70                  75                  80
Leu His Glu Val Tyr Glu Pro Asp Trp Tyr Gly Arg Glu Asp Val Lys 
                 85                  90                  95
Met Val Gly Glu Lys Cys Asp Val Leu Trp Glu Asp Phe His Gln Lys 
             100                105                110
Leu Val Asp Gly Ser Leu Leu Thr Leu Asp Thr Tyr Leu Gly Gln Phe 
         115                120                125
Pro Asp Ile Lys Asn Arg Ile Ala Lys Arg Ser Arg Lys Leu Val Asp 
     130                135                140
Tyr Asp Ser Ala Arg His His Leu Glu Ala Leu Gln Ser Ser Lys Arg 
 145                150                155                160
Lys Asp Glu Ser Arg Ile Ser Lys Ala Glu Glu Glu Phe Gln Lys Ala 
                 165                170                175
Gln Lys Val Phe Glu Glu Phe Asn Val Asp Leu Gln Glu Glu Leu Pro 
             180                185                190
Ser Leu Trp Ser Arg Arg Val Gly Phe Tyr Val Asn Thr Phe Lys Asn 
         195                200                205
Val Ser Ser Leu Glu Ala Lys Phe His Lys Glu Ile Ala Val Leu Cys 
     210                215                220
His Lys Leu Tyr Glu Val Met Thr Lys Leu Gly Asp Gln His Ala Asp 
 225                230                235                240
Lys Ala Phe Ser Ile Gln Gly Ala Pro Ser Asp Ser Gly Pro Leu Arg 
                 245                250                255
Ile Ala Lys Thr Pro Ser Pro Pro Glu Glu Ala Ser Pro Leu Pro Ser 
             260                265                270
Pro Thr Ala Ser Pro Asn His Thr Leu Ala Pro Ala Ser Pro Ala Pro 
         275                280                285
Val Arg Pro Arg Ser Pro Ser Gln Thr Arg Lys Gly Pro Pro Val Pro 
     290                295                300
Pro Leu Pro Lys Val Thr Pro Thr Lys Glu Leu Gln Gln Glu Asn Ile 
 305                310                315                320
Ile Asn Phe Phe Glu Asp Asn Phe Val Pro Glu Ile Asn Val Thr Thr 
                 325                330                335
Pro Ser Gln Asn Glu Val Leu Glu Val Lys Lys Glu Glu Thr Leu Leu 
             340                345                350
Asp Leu Asp Phe Asp Pro Phe Lys Pro Asp Val Thr Pro Ala Gly Ser 
         355                360                365
Ala Ala Ala Thr His Ser Pro Met Ser Gln Thr Leu Pro Trp Asp Leu 
     370                375                380
Trp Thr Thr Ser Thr Asp Leu Val Gln Pro Ala Ser Gly Gly Ser Phe 
 385                390                395                400
Asn Asp Phe Thr Gln Pro Gln Asp Thr Ser Leu Phe Thr Met Gln Thr 
                 405                410                415
Asp Gln Asn Met Ala Glu Thr Glu Gln Ala Leu Pro Thr Glu Pro Gln 
             420                425                430
Ala Glu Glu Pro Pro Thr Thr Ala Ala Ala Pro Thr Ala Gly Leu Asp 
         435                440                445
Leu Gly Leu Glu Met Glu Glu Pro Lys Glu Glu Ala Ala Ile Pro Pro 
     450                455                460
Gly Thr Asp Ala Gly Glu Thr Val Gly Thr Glu Gly Ser Thr Gly Glu 
 465                470                475                480
Glu Ala Glu Ala Glu Lys Ala Ala Leu Pro Ala Gly Glu Gly Glu Ser 
                 485                490                495
Pro Glu Gly Ala Lys Ile Asp Val Glu Ser Thr Glu Leu Ala Ser Ser 
             500                505                510
Glu Ser Pro Gln Ala Ala Glu Leu Glu Ala Gly Ala Pro Gln Glu Lys 
         515                520                525
Val Ile Pro Ser Val Val Ile Glu Pro Ala Ser Asn His Glu Gly Glu 
     530                535                540
Glu His Gln Glu Thr Thr Thr Gly Thr Glu Thr Arg Glu Ala Thr Glu 
 545                550                555                560
Asp Val Ala Pro Gln Gly Pro Ala Gly Glu Lys Gln Glu Leu Ala Thr 
                 565                570                575
Glu Pro Thr Pro Leu Asp Ser Gln Ala Ala Thr Pro Ala Pro Ala Gly 
             580                585                590
Ala Val Asp Ala Ser Leu Ser Ala Gly Asp Ala Ala Gln Glu Leu Pro 
         595                600                605
Pro Gly Phe Leu Tyr Lys Val Glu Thr Leu His Asp Phe Glu Ala Ala 
     610                615                620
Asn Ser Asp Glu Leu Thr Leu Gln Arg Gly Asp Val Val Leu Val Val 
 625                630                635                640
Pro Ser Asp Ser Glu Ala Asp Gln Asp Ala Gly Trp Leu Val Gly Val 
                 645                650                655
Lys Glu Ser Asp Trp Leu Gln Tyr Arg Asp Leu Ala Thr Tyr Lys Gly 
             660                665                670
Leu Phe Pro Glu Asn Phe Thr Arg His Leu Glu 
         675                680



<210> 10319
<211> 2377
<212> DNA
<213> Homo sapiens
<308> U07616
<400> 10319

cggctctca  ctgcactcc  gtacatcca  ctgtcttca  gagagcact  tttgtgtgt  60
cccagcccc  ctgcgcgct  tgctcttcg  agctccccg  acccgcagc  atggccgac  120
tcaagacgg  catcttcgc  aagaacgtc  agaagcgac  caaccgcgc  caggaaaag  180
tcctccaaa  gctggggaa  gctgatgag  caaaagacg  acagttcga  gaatatgtc  240
agaacttca  acggcaaga  gcagagggt  ccagacttc  gcgagaact  cgaggatat  300
tagcagcaa  caaaggcat  caggaggcc  ccatgaagc  cacagagtc  ctgcatgaa  360
tctatgagc  tgactggta  gggcgggaa  atgtgaaaa  ggttggtga  aaatgtgat  420
tgctgtggg  agacttcca  caaaaactc  tggatgggt  cttgctaac  ctggatacc  480
acctggggc  atttcctga  ataaagaat  gcatcgcca  gcgcagcag  aagctagtg  540
actatgaca  tgcccgcca  catctggaa  ctctgcaga  ctccaagag  aaggatgag  600
gtcgaatct  taaggcaga  gaagaattt  agaaagcac  gaaagtgtt  gaagagttt  660
acgttgact  acaagaaga  ttaccatca  tatggtcaa  acgagttgg  ttttatgtt  720
atactttca  aaacgtctc  agccttgaa  ccaagtttc  taaggaaat  gcggtgctt  780
gccacaaac  gtatgaagt  atgacaaaa  tgggtgacc  gcacgccga  aaggccttc  840
ccatccaag  agcgcccag  gattcgggt  ctctccgca  tgcaaagac  ccatcaccg  900
ctgaggagc  ttcacccct  ccgagcccg  cagcaagtc  aaatcatac  ttagcacct  960
cgtctcccg  accagcacg  cctcggtca  cttcacaga  aaggaaagg  cctcctgtc  1020
cacctctac  taaagtcac  ccgacaaag  aactgcagc  ggagaacat  atcagtttc  1080
ttgaggaca  ctttgttcc  gaaatcagt  tgacaacac  ttcccagaa  gaagtccct  1140
aggtgaaga  agaggagac  ttgctggat  tggactttg  tcctttcaa  cccgaggtg  1200
cacctgcag  ttctgctgg  gtgacccac  cacccatgt  tcagacatt  ccctgggac  1260
tatggacga  aagcactga  ttggtacag  cggcttctg  tggttcatt  aatggattc  1320
cacagcccc  ggatacttc  ttattcaca  tgcagacag  ccagagtat  atctgcaac  1380
tggctgaat  tgaacaggc  ccacccaca  agccaaaag  agaggagcc  ctggctgct  1440
tcacacctg  cgttggtct  gaccttgga  tggacactc  ggctgagga  ccagtggag  1500
aggcagtga  catacctgg  gctgatgct  atgcagctg  tggaacctt  gtgtcagca  1560
ctgaggggg  cccaggaga  gaagcagag  cggagaagg  cactgtccc  gccggggaa  1620
gagtaagtt  agaggaggc  aaaattgga  ctgaaacca  tgagggtgc  gagagtgcc  1680
aacctgaag  agaggagct  gaagcaaca  tgcctcagg  gaaggtcat  ccttcggtg  1740
tcatagagc  tgcctccaa  catgaagag  aaggagaaa  cgaaataac  ataggtgca  1800
agcccaagg  gaccaccga  gacgcggct  ctccgggcc  caccagcga  acaccggag  1860
tggctacgg  gcagaagcc  atccaggac  ctcagccca  gccttctgc  ccagccatg  1920
gggctgctg  ccagctagc  tctgcaagg  aggcctctc  ggaattgcc  cctggcttt  1980
tctacaagg  ggaaacact  catgatttt  aggcagcaa  ttctgatga  cttacctta  2040
aaaggggtg  tgtggtgct  gtggtcccc  cagattcag  agctgatca  gatgcaggc  2100
ggctggtgg  agtgaagga  tcagactgg  ttcagtaca  agaccttgc  acctacaaa  2160
gcctctttc  agagaactt  acccgacgc  tagattagg  caacaagta  tgcaagaag  2220
agctcagtt  cggggtttt  aaaccttca  gaaaacctg  agagttcac  tttgttatt  2280
tgctcttaa  gatttacag  ctgatgcca  acaaacctt  ggaagatgt  tcaatggag  2340
atgtgtgca  aaaaatgta  gaggaaaaa  aaaaccg  2377



<210> 10320
<211> 695
<212> PRT
<213> Homo sapiens
<308> P49418
<400> 10320

Met Ala Asp Ile Lys Thr Gly Ile Phe Ala Lys Asn Val Gln Lys Arg 
  1               5                  10                  15
Leu Asn Arg Ala Gln Glu Lys Val Leu Gln Lys Leu Gly Lys Ala Asp 
             20                  25                  30
Glu Thr Lys Asp Glu Gln Phe Glu Glu Tyr Val Gln Asn Phe Lys Arg 
         35                  40                  45
Gln Glu Ala Glu Gly Thr Arg Leu Gln Arg Glu Leu Arg Gly Tyr Leu 
     50                  55                  60
Ala Ala Ile Lys Gly Met Gln Glu Ala Ser Met Lys Leu Thr Glu Ser 
 65                  70                  75                  80
Leu His Glu Val Tyr Glu Pro Asp Trp Tyr Gly Arg Glu Asp Val Lys 
                 85                  90                  95
Met Val Gly Glu Lys Cys Asp Val Leu Trp Glu Asp Phe His Gln Lys 
             100                105                110
Leu Val Asp Gly Ser Leu Leu Thr Leu Asp Thr Tyr Leu Gly Gln Phe 
         115                120                125
Pro Asp Ile Lys Asn Arg Ile Ala Lys Arg Ser Arg Lys Leu Val Asp 
     130                135                140
Tyr Asp Ser Ala Arg His His Leu Glu Ala Leu Gln Ser Ser Lys Arg 
 145                150                155                160
Lys Asp Glu Ser Arg Ile Ser Lys Ala Glu Glu Glu Phe Gln Lys Ala 
                 165                170                175
Gln Lys Val Phe Glu Glu Phe Asn Val Asp Leu Gln Glu Glu Leu Pro 
             180                185                190
Ser Leu Trp Ser Arg Arg Val Gly Phe Tyr Val Asn Thr Phe Lys Asn 
         195                200                205
Val Ser Ser Leu Glu Ala Lys Phe His Lys Glu Ile Ala Val Leu Cys 
     210                215                220
His Lys Leu Tyr Glu Val Met Thr Lys Leu Gly Asp Gln His Ala Asp 
 225                230                235                240
Lys Ala Phe Thr Ile Gln Gly Ala Pro Ser Asp Ser Gly Pro Leu Arg 
                 245                250                255
Ile Ala Lys Thr Pro Ser Pro Pro Glu Glu Pro Ser Pro Leu Pro Ser 
             260                265                270
Pro Thr Ala Ser Pro Asn His Thr Leu Ala Pro Ala Ser Pro Ala Pro 
         275                280                285
Ala Arg Pro Arg Ser Pro Ser Gln Thr Arg Lys Gly Pro Pro Val Pro 
     290                295                300
Pro Leu Pro Lys Val Thr Pro Thr Lys Glu Leu Gln Gln Glu Asn Ile 
 305                310                315                320
Ile Ser Phe Phe Glu Asp Asn Phe Val Pro Glu Ile Ser Val Thr Thr 
                 325                330                335
Pro Ser Gln Asn Glu Val Pro Glu Val Lys Lys Glu Glu Thr Leu Leu 
             340                345                350
Asp Leu Asp Phe Asp Pro Phe Lys Pro Glu Val Thr Pro Ala Gly Ser 
         355                360                365
Ala Gly Val Thr His Ser Pro Met Ser Gln Thr Leu Pro Trp Asp Leu 
     370                375                380
Trp Thr Thr Ser Thr Asp Leu Val Gln Pro Ala Ser Gly Gly Ser Phe 
 385                390                395                400
Asn Gly Phe Thr Gln Pro Gln Asp Thr Ser Leu Phe Thr Met Gln Thr 
                 405                410                415
Asp Gln Ser Met Ile Cys Asn Leu Ala Glu Ser Glu Gln Ala Pro Pro 
             420                425                430
Thr Glu Pro Lys Ala Glu Glu Pro Leu Ala Ala Val Thr Pro Ala Val 
         435                440                445
Gly Leu Asp Leu Gly Met Asp Thr Arg Ala Glu Glu Pro Val Glu Glu 
     450                455                460
Ala Val Ile Ile Pro Gly Ala Asp Ala Asp Ala Ala Val Gly Thr Leu 
 465                470                475                480
Val Ser Ala Ala Glu Gly Ala Pro Gly Glu Glu Ala Glu Ala Glu Lys 
                 485                490                495
Ala Thr Val Pro Ala Gly Glu Gly Val Ser Leu Glu Glu Ala Lys Ile 
             500                505                510
Gly Thr Glu Thr Thr Glu Gly Ala Glu Ser Ala Gln Pro Glu Ala Glu 
         515                520                525
Glu Leu Glu Ala Thr Val Pro Gln Glu Lys Val Ile Pro Ser Val Val 
     530                535                540
Ile Glu Pro Ala Ser Asn His Glu Glu Glu Gly Glu Asn Glu Ile Thr 
 545                550                555                560
Ile Gly Ala Glu Pro Lys Glu Thr Thr Glu Asp Ala Ala Pro Pro Gly 
                 565                570                575
Pro Thr Ser Glu Thr Pro Glu Leu Ala Thr Glu Gln Lys Pro Ile Gln 
             580                585                590
Asp Pro Gln Pro Thr Pro Ser Ala Pro Ala Met Gly Ala Ala Asp Gln 
         595                600                605
Leu Ala Ser Ala Arg Glu Ala Ser Gln Glu Leu Pro Pro Gly Phe Leu 
     610                615                620
Tyr Lys Val Glu Thr Leu His Asp Phe Glu Ala Ala Asn Ser Asp Glu 
 625                630                635                640
Leu Thr Leu Gln Arg Gly Asp Val Val Leu Val Val Pro Ser Asp Ser 
                 645                650                655
Glu Ala Asp Gln Asp Ala Gly Trp Leu Val Gly Val Lys Glu Ser Asp 
             660                665                670
Trp Leu Gln Tyr Arg Asp Leu Ala Thr Tyr Lys Gly Leu Phe Pro Glu 
         675                680                685
Asn Phe Thr Arg Arg Leu Asp 
     690                695



<210> 10321
<211> 2024
<212> DNA
<213> Rattus norvegicus
<308> Y13413
<400> 10321

ggtcttccg  cgtcggagg  actcttagt  accgaccgg  gcggagttc  tcgtgtcag  60
acgcttcgt  ggacacacg  accgaaaca  gcgaggact  gggaaacca  acgcacagg  120
agctcaggc  cgcctctgc  ctcccccaa  gccgtccct  tcccgccca  tgtttgttt  180
cgcggtgcc  gttggcccg  cggtctccg  cgcagagag  ctgggcttg  gtgccctgc  240
gctccggag  tcgccttgg  ctgagaacg  aggccagtc  agactatgc  gggcaagga  300
tatatgctg  ccatcattc  ggtcaactg  gatgatgac  tgtgggggg  ccaaaatct  360
gagggggaa  caggcctac  ccctggctg  agaaagatc  gtgatgctg  aggaactta  420
tattggcat  tacccagcg  tagcactca  tggcagcgc  caacctggg  actagcaga  480
gacccagga  cgggaaaag  ggggatttg  gaactacga  ctcccaagg  gagatcttt  540
tccagcctg  acagctcat  gaaccgaag  aactctcta  catggtata  tgaagattc  600
tatgtccgg  gcctggagc  aggagctaa  tgctttgca  tccgctctc  gggctgggt  660
gaggtccct  aggaggacc  ggcaccagg  aagagcagt  ttgctgtca  taactgtat  720
cagcagcta  cccaggccc  aaaccggag  cagcctcat  atggtgcct  gggtgaggg  780
cagaacatg  tgatggtcc  gaaaaaaga  gccatgagc  tgctgaatc  cctggacca  840
agtctgatc  attgtcagc  tctggttca  atccgtgta  ggggtgtgg  cagctccaa  900
ggccgtgac  gggactttg  ttttgttgc  ggtgacaaa  acagctgta  gcttaaatg  960
catgtgttt  gctgtgatg  gcccgcaaa  gccatagca  gtcgtctac  ggggctctg  1020
gcacagatc  tgtcagaga  ggtaggact  agtggagaa  ctgcttgtt  ttccccaga  1080
cctatttcc  ctgaagact  cccaaggca  gtggaattg  tggatgcag  gagccaggc  1140
gctcagaag  atgaggcac  gtacatggg  atcctacca  tcaccaaag  catgggtat  1200
gatgtgctg  atgaggcca  tggtaccct  actggccgt  gggaccgga  aacctgggt  1260
cccgctatg  tcagtgtgt  tgactctct  atgactgca  atcctattc  ggcagaggc  1320
ggtgcagag  aagagccac  gtggcagtg  cctgtccgc  ttgtaacct  tattggtgt  1380
ggccatgat  cacatacct  tggcctcat  gctgatctt  gttgtcaga  cttccagtg  1440
gcagctttc  ggtgccaac  tcatgctgg  ggactctct  aagctgtgc  agctgcctg  1500
atggttcag  accagaagt  tctagtggc  tcagcagct  ggggtaagg  ctggggtgc  1560
caggctcgc  ctcgcctgc  gctcaagcg  accagctcc  tggactccc  aggcggccc  1620
cttcctccc  ctctactca  aggaggggt  gggggtgct  gagcagctc  tcgaaagcg  1680
ggtgtcttc  catttcttg  tgccttcag  ctaaaacct  tcttctcca  atgtcctaa  1740
ttgatctta  agggctggg  aaagaggct  tatactctt  cagtcccta  ggttctgta  1800
cctctcacc  tcctgccat  cctgatccc  tgcctactc  gtatttatg  ccaagttcg  1860
tgtttatat  gatgactga  aggccctgc  ctctaactt  ggcctgtag  accactttc  1920
tttggtcct  ttgttcctt  cccctgtcc  gccctgaca  ttggctcta  ctcatcaac  1980
ttatagcag  atcagtgaa  ataaaaatc  ctcagtaaa  aaaa  2024



<210> 10322
<211> 504
<212> PRT
<213> Rattus norvegicus
<308> O35827
<400> 10322

Met Leu Gly Lys Asp Tyr Met Leu Ala Ile Ile Leu Val Asn Cys Asp 
  1               5                  10                  15
Asp Asp Leu Trp Gly Asp Gln Asn Leu Glu Gly Glu Thr Gly Leu Pro 
             20                  25                  30
Pro Gly Trp Arg Lys Ile Arg Asp Ala Ala Gly Thr Tyr Tyr Trp His 
         35                  40                  45
Val Pro Ser Gly Ser Thr Gln Trp Gln Arg Pro Thr Trp Glu Leu Ala 
     50                  55                  60
Glu Asp Pro Gly Thr Gly Lys Glu Gly Ile Trp Glu Leu Arg Pro Pro 
 65                  70                  75                  80
Lys Gly Arg Ser Phe Ser Ser Leu Asp Ser Ser Leu Asn Arg Ser Asn 
                 85                  90                  95
Ser Leu Thr Trp Tyr Asn Glu Asp Ser Tyr Val Arg Ser Leu Glu Pro 
             100                105                110
Gly Ala Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Val Pro 
         115                120                125
Glu Glu Asp Leu Ala Pro Gly Lys Ser Ser Ile Ala Val Asn Asn Cys 
     130                135                140
Ile Gln Gln Leu Ala Gln Ala Arg Asn Arg Ser Gln Pro His Asp Gly 
 145                150                155                160
Ala Trp Gly Glu Gly Gln Asn Met Leu Met Val Leu Lys Lys Asp Ala 
                 165                170                175
Met Ser Leu Leu Asn Pro Leu Asp His Ser Leu Ile His Cys Gln Pro 
             180                185                190
Leu Val His Ile Arg Val Trp Gly Val Gly Ser Ser Lys Gly Arg Asp 
         195                200                205
Arg Asp Phe Ala Phe Val Ala Gly Asp Lys Asp Ser Cys Met Leu Lys 
     210                215                220
Cys His Val Phe Arg Cys Asp Val Pro Ala Lys Ala Ile Ala Ser Arg 
 225                230                235                240
Leu Gln Gly Leu Cys Ala Gln Ile Leu Ser Glu Arg Val Gly Leu Ser 
                 245                250                255
Gly Glu Ala Ala Cys Cys Ser Pro Asp Pro Ile Ser Pro Glu Asp Phe 
             260                265                270
Pro Arg Gln Val Glu Leu Leu Asp Ala Val Ser Gln Ala Ala Gln Lys 
         275                280                285
Tyr Glu Ala Leu Tyr Met Gly Ile Leu Pro Val Thr Lys Ala Met Gly 
     290                295                300
Met Asp Val Leu Asn Glu Ala Ile Gly Thr Leu Thr Gly Arg Gly Asp 
 305                310                315                320
Arg Lys Thr Trp Val Pro Ala Met Leu Ser Val Ser Asp Ser Leu Met 
                 325                330                335
Thr Ala His Pro Ile Gln Ala Glu Ala Gly Ala Glu Glu Glu Pro Leu 
             340                345                350
Trp Gln Cys Pro Val Arg Leu Val Thr Phe Ile Gly Val Gly His Asp 
         355                360                365
Pro His Thr Phe Gly Leu Ile Ala Asp Leu Gly Cys Gln Ser Phe Gln 
     370                375                380
Cys Ala Ala Phe Trp Cys Gln Pro His Ala Gly Gly Leu Ser Glu Ala 
 385                390                395                400
Val Gln Ala Ala Cys Met Val Gln Tyr Gln Lys Cys Leu Val Ala Ser 
                 405                410                415
Ala Ala Arg Gly Lys Ala Trp Gly Ala Gln Ala Arg Ala Arg Leu Arg 
             420                425                430
Leu Lys Arg Thr Ser Ser Met Asp Ser Pro Gly Gly Pro Leu Pro Pro 
         435                440                445
Pro Leu Leu Lys Gly Gly Val Gly Gly Ala Gly Ala Ala Pro Arg Lys 
     450                455                460
Arg Gly Val Phe Ser Phe Leu Asp Ala Phe Arg Leu Lys Pro Leu Phe 
 465                470                475                480
Ser Ile Cys Pro Lys Leu Ile Leu Glu Gly Trp Gly Lys Arg Leu Tyr 
                 485                490                495
Thr Leu Pro Val Pro Arg Val Leu 
             500



<210> 10323
<211> 1809
<212> DNA
<213> Homo sapiens
<308> AF224708
<400> 10323

catatggag  agccggggt  atgctgggc  aggattaca  gctggccat  attctggtc  60
actgcgatg  tgacttgtg  ggggaccac  gtctggagg  ggaggctgg  ctgcctcct  120
gctggagga  gatccacga  gctgcaggt  cttactact  gcatgtacc  agcggtagc  180
cccagtggc  gcgcccaac  tgggaacta  gagatgcag  ggacccagg  acgggaacg  240
aggggatct  gggactgcg  ccccccaaa  ggagatcct  ctccagcct  gagagttca  300
tggaccgga  taactctct  tcctggtat  gtggggaat  ctacatcca  agcatggag  360
caggggcta  gtgctttgc  gtccgctct  tgggctggg  agaggtacc  gaagaggac  420
tggcaccgg  gaagagcag  attgcagtc  ataactgta  ccagcagct  gcccagacc  480
gcagccgga  ccagcctcc  gatggtgcc  ggggtgagg  ccagaacat  ctgatgatc  540
tgaagaagg  tgccatgag  ctagtgaat  ccctggacc  cagtctgat  cactgccag  600
ctctggtgc  catccgtgt  tggggcgtg  ggagctcca  gggccgccc  atctctgcc  660
ctgctaggg  cttcgcttt  gtggcaagt  acaaagata  ctgtatgct  aagtgccat  720
tgtttcgct  tgatgtccc  gccaaggcc  ttgccagtg  cctacatgg  ctttgtgcc  780
agatcttgt  agagcgagt  gaggtcagt  gtgatgcct  ttgctgctc  ccagacccc  840
tctctcctg  agacctgcc  cggcaagtg  agctgctag  tgcggtaag  caagctgct  900
agaagtacg  ggcactgta  atggggaca  tgccagtca  caaggccat  ggcatggat  960
tgctgaacg  ggccattgg  accctcact  ccagggggg  ccggaatgc  tgggtcccc  1020
ccatgctca  tgtgtctga  tctctcatg  ctgcacatc  cattcaggc  gaggccagt  1080
cagaggagg  gccattgtg  cagtgccct  tgcgccttg  gacatttat  ggtgttggc  1140
gcgacccac  cacctttgg  ctcatcgct  acctgggcc  tcagagctt  cagtgcgca  1200
ccttctggt  ccagcccca  gcaggggga  tctctgaag  tgtgcaggc  gcctgtatg  1260
ttcagtacc  gaagtgtct  gtggcctct  cagctcgag  caaggcctg  ggtgcccag  1320
cccgtgccc  cctgcggct  aagcggacc  gctccatgg  ttccccagg  ggtcccctg  1380
ccctccccc  gctcaaagg  ggggttggc  gtgcagggg  aacccctcg  aagcggggt  1440
tcttctctt  tcttgatgc  ttccggctg  aaccctctc  gctccatat  ccctaaact  1500
atctgggaa  gctggggaa  taggctctg  gtccatgcc  aactctgta  cgttttatt  1560
ctcaaggcc  atagcctgt  actccttga  gccttctct  cctgtccct  cgatccttg  1620
ccaccgtct  tttattgcc  aatttattg  ttatacgga  gactgggag  cactgcgcc  1680
caacgtagg  ccctggctc  cctttcctt  ggtccttgt  ttccttgcc  ctgtccaac  1740
ctggacagt  ggctctacc  cagtaacac  ttatagcaa  atcagtgca  ataaaaatc  1800
ctcagtgac  1809



<210> 10324
<211> 486
<212> PRT
<213> Homo sapiens
<308> O95704
<400> 10324

Met Leu Gly Lys Asp Tyr Met Leu Ala Ile Ile Leu Val Asn Cys Asp 
  1               5                  10                  15
Asp Asp Leu Trp Gly Asp His Ser Leu Glu Val Glu Ala Gly Leu Pro 
             20                  25                  30
Pro Gly Trp Arg Lys Ile His Asp Ala Ala Gly Thr Tyr Tyr Trp His 
         35                  40                  45
Val Pro Ser Gly Ser Thr Gln Trp Gln Arg Pro Thr Trp Glu Leu Gly 
     50                  55                  60
Asp Ala Glu Asp Pro Gly Thr Gly Thr Glu Gly Ile Trp Gly Leu Arg 
 65                  70                  75                  80
Pro Pro Lys Gly Arg Ser Phe Ser Ser Leu Glu Ser Ser Leu Asp Arg 
                 85                  90                  95
Ser Asn Ser Leu Ser Trp Tyr Gly Gly Glu Ser Tyr Ile Gln Ser Met 
             100                105                110
Glu Pro Gly Ala Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu 
         115                120                125
Val Pro Glu Glu Asp Leu Ala Pro Gly Lys Ser Ser Ile Ala Val Asn 
     130                135                140
Asn Cys Ile Gln Gln Leu Ala Gln Thr Arg Ser Arg Ser Gln Pro Pro 
 145                150                155                160
Asp Gly Ala Trp Gly Glu Gly Gln Asn Met Leu Met Ile Leu Lys Lys 
                 165                170                175
Asp Ala Met Ser Leu Val Asn Pro Leu Asp His Ser Leu Ile His Cys 
             180                185                190
Gln Pro Leu Val His Ile Arg Val Trp Gly Val Gly Ser Ser Lys Gly 
         195                200                205
Arg Asp Arg Asp Phe Ala Phe Val Ala Ser Asp Lys Asp Ser Cys Met 
     210                215                220
Leu Lys Cys His Val Phe Arg Cys Asp Val Pro Ala Lys Ala Ile Ala 
 225                230                235                240
Ser Ala Leu His Gly Leu Cys Ala Gln Ile Leu Ser Glu Arg Val Glu 
                 245                250                255
Val Ser Gly Asp Ala Ser Cys Cys Ser Pro Asp Pro Ile Ser Pro Glu 
             260                265                270
Asp Leu Pro Arg Gln Val Glu Leu Leu Asp Ala Val Ser Gln Ala Ala 
         275                280                285
Gln Lys Tyr Glu Ala Leu Tyr Met Gly Thr Leu Pro Val Thr Lys Ala 
     290                295                300
Met Gly Met Asp Val Leu Asn Glu Ala Ile Gly Thr Leu Thr Ala Arg 
 305                310                315                320
Gly Asp Arg Asn Ala Trp Val Pro Thr Met Leu Ser Val Ser Asp Ser 
                 325                330                335
Leu Met Thr Ala His Pro Ile Gln Ala Glu Ala Ser Thr Glu Glu Glu 
             340                345                350
Pro Leu Trp Gln Cys Pro Val Arg Leu Val Thr Phe Ile Gly Val Gly 
         355                360                365
Arg Asp Pro His Thr Phe Gly Leu Ile Ala Asp Leu Gly Arg Gln Ser 
     370                375                380
Phe Gln Cys Ala Ala Phe Trp Cys Gln Pro His Ala Gly Gly Leu Ser 
 385                390                395                400
Glu Ala Val Gln Ala Ala Cys Met Val Gln Tyr Gln Lys Cys Leu Val 
                 405                410                415
Ala Ser Ala Ala Arg Gly Lys Ala Trp Gly Ala Gln Ala Arg Ala Arg 
             420                425                430
Leu Arg Leu Lys Arg Thr Ser Ser Met Asp Ser Pro Gly Gly Pro Leu 
         435                440                445
Pro Leu Pro Leu Leu Lys Gly Gly Val Gly Gly Ala Gly Ala Thr Pro 
     450                455                460
Arg Lys Arg Gly Val Phe Ser Phe Leu Asp Ala Phe Arg Leu Lys Pro 
 465                470                475                480
Ser Leu Leu His Met Pro 
                 485



<210> 10325
<211> 2024
<212> DNA
<213> Rattus norvegicus
<308> Y13413
<400> 10325

ggtcttccg  cgtcggagg  actcttagt  accgaccgg  gcggagttc  tcgtgtcag  60
acgcttcgt  ggacacacg  accgaaaca  gcgaggact  gggaaacca  acgcacagg  120
agctcaggc  cgcctctgc  ctcccccaa  gccgtccct  tcccgccca  tgtttgttt  180
cgcggtgcc  gttggcccg  cggtctccg  cgcagagag  ctgggcttg  gtgccctgc  240
gctccggag  tcgccttgg  ctgagaacg  aggccagtc  agactatgc  gggcaagga  300
tatatgctg  ccatcattc  ggtcaactg  gatgatgac  tgtgggggg  ccaaaatct  360
gagggggaa  caggcctac  ccctggctg  agaaagatc  gtgatgctg  aggaactta  420
tattggcat  tacccagcg  tagcactca  tggcagcgc  caacctggg  actagcaga  480
gacccagga  cgggaaaag  ggggatttg  gaactacga  ctcccaagg  gagatcttt  540
tccagcctg  acagctcat  gaaccgaag  aactctcta  catggtata  tgaagattc  600
tatgtccgg  gcctggagc  aggagctaa  tgctttgca  tccgctctc  gggctgggt  660
gaggtccct  aggaggacc  ggcaccagg  aagagcagt  ttgctgtca  taactgtat  720
cagcagcta  cccaggccc  aaaccggag  cagcctcat  atggtgcct  gggtgaggg  780
cagaacatg  tgatggtcc  gaaaaaaga  gccatgagc  tgctgaatc  cctggacca  840
agtctgatc  attgtcagc  tctggttca  atccgtgta  ggggtgtgg  cagctccaa  900
ggccgtgac  gggactttg  ttttgttgc  ggtgacaaa  acagctgta  gcttaaatg  960
catgtgttt  gctgtgatg  gcccgcaaa  gccatagca  gtcgtctac  ggggctctg  1020
gcacagatc  tgtcagaga  ggtaggact  agtggagaa  ctgcttgtt  ttccccaga  1080
cctatttcc  ctgaagact  cccaaggca  gtggaattg  tggatgcag  gagccaggc  1140
gctcagaag  atgaggcac  gtacatggg  atcctacca  tcaccaaag  catgggtat  1200
gatgtgctg  atgaggcca  tggtaccct  actggccgt  gggaccgga  aacctgggt  1260
cccgctatg  tcagtgtgt  tgactctct  atgactgca  atcctattc  ggcagaggc  1320
ggtgcagag  aagagccac  gtggcagtg  cctgtccgc  ttgtaacct  tattggtgt  1380
ggccatgat  cacatacct  tggcctcat  gctgatctt  gttgtcaga  cttccagtg  1440
gcagctttc  ggtgccaac  tcatgctgg  ggactctct  aagctgtgc  agctgcctg  1500
atggttcag  accagaagt  tctagtggc  tcagcagct  ggggtaagg  ctggggtgc  1560
caggctcgc  ctcgcctgc  gctcaagcg  accagctcc  tggactccc  aggcggccc  1620
cttcctccc  ctctactca  aggaggggt  gggggtgct  gagcagctc  tcgaaagcg  1680
ggtgtcttc  catttcttg  tgccttcag  ctaaaacct  tcttctcca  atgtcctaa  1740
ttgatctta  agggctggg  aaagaggct  tatactctt  cagtcccta  ggttctgta  1800
cctctcacc  tcctgccat  cctgatccc  tgcctactc  gtatttatg  ccaagttcg  1860
tgtttatat  gatgactga  aggccctgc  ctctaactt  ggcctgtag  accactttc  1920
tttggtcct  ttgttcctt  cccctgtcc  gccctgaca  ttggctcta  ctcatcaac  1980
ttatagcag  atcagtgaa  ataaaaatc  ctcagtaaa  aaaa  2024



<210> 10326
<211> 504
<212> PRT
<213> Rattus norvegicus
<308> O35827
<400> 10326

Met Leu Gly Lys Asp Tyr Met Leu Ala Ile Ile Leu Val Asn Cys Asp 
  1               5                  10                  15
Asp Asp Leu Trp Gly Asp Gln Asn Leu Glu Gly Glu Thr Gly Leu Pro 
             20                  25                  30
Pro Gly Trp Arg Lys Ile Arg Asp Ala Ala Gly Thr Tyr Tyr Trp His 
         35                  40                  45
Val Pro Ser Gly Ser Thr Gln Trp Gln Arg Pro Thr Trp Glu Leu Ala 
     50                  55                  60
Glu Asp Pro Gly Thr Gly Lys Glu Gly Ile Trp Glu Leu Arg Pro Pro 
 65                  70                  75                  80
Lys Gly Arg Ser Phe Ser Ser Leu Asp Ser Ser Leu Asn Arg Ser Asn 
                 85                  90                  95
Ser Leu Thr Trp Tyr Asn Glu Asp Ser Tyr Val Arg Ser Leu Glu Pro 
             100                105                110
Gly Ala Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Val Pro 
         115                120                125
Glu Glu Asp Leu Ala Pro Gly Lys Ser Ser Ile Ala Val Asn Asn Cys 
     130                135                140
Ile Gln Gln Leu Ala Gln Ala Arg Asn Arg Ser Gln Pro His Asp Gly 
 145                150                155                160
Ala Trp Gly Glu Gly Gln Asn Met Leu Met Val Leu Lys Lys Asp Ala 
                 165                170                175
Met Ser Leu Leu Asn Pro Leu Asp His Ser Leu Ile His Cys Gln Pro 
             180                185                190
Leu Val His Ile Arg Val Trp Gly Val Gly Ser Ser Lys Gly Arg Asp 
         195                200                205
Arg Asp Phe Ala Phe Val Ala Gly Asp Lys Asp Ser Cys Met Leu Lys 
     210                215                220
Cys His Val Phe Arg Cys Asp Val Pro Ala Lys Ala Ile Ala Ser Arg 
 225                230                235                240
Leu Gln Gly Leu Cys Ala Gln Ile Leu Ser Glu Arg Val Gly Leu Ser 
                 245                250                255
Gly Glu Ala Ala Cys Cys Ser Pro Asp Pro Ile Ser Pro Glu Asp Phe 
             260                265                270
Pro Arg Gln Val Glu Leu Leu Asp Ala Val Ser Gln Ala Ala Gln Lys 
         275                280                285
Tyr Glu Ala Leu Tyr Met Gly Ile Leu Pro Val Thr Lys Ala Met Gly 
     290                295                300
Met Asp Val Leu Asn Glu Ala Ile Gly Thr Leu Thr Gly Arg Gly Asp 
 305                310                315                320
Arg Lys Thr Trp Val Pro Ala Met Leu Ser Val Ser Asp Ser Leu Met 
                 325                330                335
Thr Ala His Pro Ile Gln Ala Glu Ala Gly Ala Glu Glu Glu Pro Leu 
             340                345                350
Trp Gln Cys Pro Val Arg Leu Val Thr Phe Ile Gly Val Gly His Asp 
         355                360                365
Pro His Thr Phe Gly Leu Ile Ala Asp Leu Gly Cys Gln Ser Phe Gln 
     370                375                380
Cys Ala Ala Phe Trp Cys Gln Pro His Ala Gly Gly Leu Ser Glu Ala 
 385                390                395                400
Val Gln Ala Ala Cys Met Val Gln Tyr Gln Lys Cys Leu Val Ala Ser 
                 405                410                415
Ala Ala Arg Gly Lys Ala Trp Gly Ala Gln Ala Arg Ala Arg Leu Arg 
             420                425                430
Leu Lys Arg Thr Ser Ser Met Asp Ser Pro Gly Gly Pro Leu Pro Pro 
         435                440                445
Pro Leu Leu Lys Gly Gly Val Gly Gly Ala Gly Ala Ala Pro Arg Lys 
     450                455                460
Arg Gly Val Phe Ser Phe Leu Asp Ala Phe Arg Leu Lys Pro Leu Phe 
 465                470                475                480
Ser Ile Cys Pro Lys Leu Ile Leu Glu Gly Trp Gly Lys Arg Leu Tyr 
                 485                490                495
Thr Leu Pro Val Pro Arg Val Leu 
             500



<210> 10327
<211> 1809
<212> DNA
<213> Homo sapiens
<308> AF224708
<400> 10327

catatggag  agccggggt  atgctgggc  aggattaca  gctggccat  attctggtc  60
actgcgatg  tgacttgtg  ggggaccac  gtctggagg  ggaggctgg  ctgcctcct  120
gctggagga  gatccacga  gctgcaggt  cttactact  gcatgtacc  agcggtagc  180
cccagtggc  gcgcccaac  tgggaacta  gagatgcag  ggacccagg  acgggaacg  240
aggggatct  gggactgcg  ccccccaaa  ggagatcct  ctccagcct  gagagttca  300
tggaccgga  taactctct  tcctggtat  gtggggaat  ctacatcca  agcatggag  360
caggggcta  gtgctttgc  gtccgctct  tgggctggg  agaggtacc  gaagaggac  420
tggcaccgg  gaagagcag  attgcagtc  ataactgta  ccagcagct  gcccagacc  480
gcagccgga  ccagcctcc  gatggtgcc  ggggtgagg  ccagaacat  ctgatgatc  540
tgaagaagg  tgccatgag  ctagtgaat  ccctggacc  cagtctgat  cactgccag  600
ctctggtgc  catccgtgt  tggggcgtg  ggagctcca  gggccgccc  atctctgcc  660
ctgctaggg  cttcgcttt  gtggcaagt  acaaagata  ctgtatgct  aagtgccat  720
tgtttcgct  tgatgtccc  gccaaggcc  ttgccagtg  cctacatgg  ctttgtgcc  780
agatcttgt  agagcgagt  gaggtcagt  gtgatgcct  ttgctgctc  ccagacccc  840
tctctcctg  agacctgcc  cggcaagtg  agctgctag  tgcggtaag  caagctgct  900
agaagtacg  ggcactgta  atggggaca  tgccagtca  caaggccat  ggcatggat  960
tgctgaacg  ggccattgg  accctcact  ccagggggg  ccggaatgc  tgggtcccc  1020
ccatgctca  tgtgtctga  tctctcatg  ctgcacatc  cattcaggc  gaggccagt  1080
cagaggagg  gccattgtg  cagtgccct  tgcgccttg  gacatttat  ggtgttggc  1140
gcgacccac  cacctttgg  ctcatcgct  acctgggcc  tcagagctt  cagtgcgca  1200
ccttctggt  ccagcccca  gcaggggga  tctctgaag  tgtgcaggc  gcctgtatg  1260
ttcagtacc  gaagtgtct  gtggcctct  cagctcgag  caaggcctg  ggtgcccag  1320
cccgtgccc  cctgcggct  aagcggacc  gctccatgg  ttccccagg  ggtcccctg  1380
ccctccccc  gctcaaagg  ggggttggc  gtgcagggg  aacccctcg  aagcggggt  1440
tcttctctt  tcttgatgc  ttccggctg  aaccctctc  gctccatat  ccctaaact  1500
atctgggaa  gctggggaa  taggctctg  gtccatgcc  aactctgta  cgttttatt  1560
ctcaaggcc  atagcctgt  actccttga  gccttctct  cctgtccct  cgatccttg  1620
ccaccgtct  tttattgcc  aatttattg  ttatacgga  gactgggag  cactgcgcc  1680
caacgtagg  ccctggctc  cctttcctt  ggtccttgt  ttccttgcc  ctgtccaac  1740
ctggacagt  ggctctacc  cagtaacac  ttatagcaa  atcagtgca  ataaaaatc  1800
ctcagtgac  1809



<210> 10328
<211> 486
<212> PRT
<213> Homo sapiens
<308> O95704
<400> 10328

Met Leu Gly Lys Asp Tyr Met Leu Ala Ile Ile Leu Val Asn Cys Asp 
  1               5                  10                  15
Asp Asp Leu Trp Gly Asp His Ser Leu Glu Val Glu Ala Gly Leu Pro 
             20                  25                  30
Pro Gly Trp Arg Lys Ile His Asp Ala Ala Gly Thr Tyr Tyr Trp His 
         35                  40                  45
Val Pro Ser Gly Ser Thr Gln Trp Gln Arg Pro Thr Trp Glu Leu Gly 
     50                  55                  60
Asp Ala Glu Asp Pro Gly Thr Gly Thr Glu Gly Ile Trp Gly Leu Arg 
 65                  70                  75                  80
Pro Pro Lys Gly Arg Ser Phe Ser Ser Leu Glu Ser Ser Leu Asp Arg 
                 85                  90                  95
Ser Asn Ser Leu Ser Trp Tyr Gly Gly Glu Ser Tyr Ile Gln Ser Met 
             100                105                110
Glu Pro Gly Ala Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu 
         115                120                125
Val Pro Glu Glu Asp Leu Ala Pro Gly Lys Ser Ser Ile Ala Val Asn 
     130                135                140
Asn Cys Ile Gln Gln Leu Ala Gln Thr Arg Ser Arg Ser Gln Pro Pro 
 145                150                155                160
Asp Gly Ala Trp Gly Glu Gly Gln Asn Met Leu Met Ile Leu Lys Lys 
                 165                170                175
Asp Ala Met Ser Leu Val Asn Pro Leu Asp His Ser Leu Ile His Cys 
             180                185                190
Gln Pro Leu Val His Ile Arg Val Trp Gly Val Gly Ser Ser Lys Gly 
         195                200                205
Arg Asp Arg Asp Phe Ala Phe Val Ala Ser Asp Lys Asp Ser Cys Met 
     210                215                220
Leu Lys Cys His Val Phe Arg Cys Asp Val Pro Ala Lys Ala Ile Ala 
 225                230                235                240
Ser Ala Leu His Gly Leu Cys Ala Gln Ile Leu Ser Glu Arg Val Glu 
                 245                250                255
Val Ser Gly Asp Ala Ser Cys Cys Ser Pro Asp Pro Ile Ser Pro Glu 
             260                265                270
Asp Leu Pro Arg Gln Val Glu Leu Leu Asp Ala Val Ser Gln Ala Ala 
         275                280                285
Gln Lys Tyr Glu Ala Leu Tyr Met Gly Thr Leu Pro Val Thr Lys Ala 
     290                295                300
Met Gly Met Asp Val Leu Asn Glu Ala Ile Gly Thr Leu Thr Ala Arg 
 305                310                315                320
Gly Asp Arg Asn Ala Trp Val Pro Thr Met Leu Ser Val Ser Asp Ser 
                 325                330                335
Leu Met Thr Ala His Pro Ile Gln Ala Glu Ala Ser Thr Glu Glu Glu 
             340                345                350
Pro Leu Trp Gln Cys Pro Val Arg Leu Val Thr Phe Ile Gly Val Gly 
         355                360                365
Arg Asp Pro His Thr Phe Gly Leu Ile Ala Asp Leu Gly Arg Gln Ser 
     370                375                380
Phe Gln Cys Ala Ala Phe Trp Cys Gln Pro His Ala Gly Gly Leu Ser 
 385                390                395                400
Glu Ala Val Gln Ala Ala Cys Met Val Gln Tyr Gln Lys Cys Leu Val 
                 405                410                415
Ala Ser Ala Ala Arg Gly Lys Ala Trp Gly Ala Gln Ala Arg Ala Arg 
             420                425                430
Leu Arg Leu Lys Arg Thr Ser Ser Met Asp Ser Pro Gly Gly Pro Leu 
         435                440                445
Pro Leu Pro Leu Leu Lys Gly Gly Val Gly Gly Ala Gly Ala Thr Pro 
     450                455                460
Arg Lys Arg Gly Val Phe Ser Phe Leu Asp Ala Phe Arg Leu Lys Pro 
 465                470                475                480
Ser Leu Leu His Met Pro 
                 485



<210> 10329
<211> 328
<212> DNA
<213> Rattus norvegicus
<308> Y13590
<400> 10329

ctggcacat  tcccagaat  agtaccaca  gagctaagg  tgtgaaaat  gagtctgag  60
agtcacaat  aagtgagcc  cctgtgatt  atgagaaaa  gccaaaagg  aagccaaag  120
aagggtcag  gccccaaac  cttcctaag  atgcatcag  tacaggaag  aagcatgct  180
acaaagaaa  agcactttc  agatcaaat  agcagatag  gtcagagaa  tcatcagaa  240
caaagacaa  atttcaaga  gcaacataa  gtttatgca  tttggtatc  gaataaaaa  300
tcttcagct  gtggatggt  acttttga  328



<210> 10330
<211> 83
<212> PRT
<213> Rattus norvegicus
<308> CAA73918
<400> 10330

Met Ser Thr Thr Gly Ala Lys Ala Val Lys Ile Glu Ser Glu Lys Ser 
  1               5                  10                  15
Gln Ser Ser Glu Pro Pro Val Ile His Glu Lys Lys Pro Lys Gly Lys 
             20                  25                  30
Pro Lys Glu Gly Ser Glu Pro Gln Thr Leu Pro Lys His Ala Ser Asp 
         35                  40                  45
Thr Gly Ser Lys His Ala His Lys Glu Lys Ala Leu Ser Arg Ser Asn 
     50                  55                  60
Glu Gln Ile Val Ser Glu Lys Ser Ser Glu Ser Lys Thr Lys Phe Gln 
 65                  70                  75                  80
Asp Ala Thr 
                 85



<210> 10331
<211> 440
<212> DNA
<213> Homo sapiens
<308> AW995804
<400> 10331

gtctcttct  tggcttctc  ttgacttta  ccatcacag  ttttccatc  tctggatct  60
cttcctctt  ccccaggct  tcagccaag  cttctacag  atcatctgg  actgtgccc  120
tcaaggtag  cggctcagg  ggtgctgac  gtatactac  catggaggt  cgacacaca  180
cctccgaca  aggagctgg  gcagcggcc  tagattctt  tgtcctttc  gttggctta  240
atggtttct  tttacattc  gaccggtca  aatcttctg  aataaatca  agaagagaa  300
cactttttg  atttttaat  caggtcctt  tgtgtgtat  aaatacaca  atatcttcc  360
tattagtca  ggaagggca  aagtggacc  aaaacaggt  agctaagac  ggcatgtct  420
gcttctggg  tgtagctcag  440



<210> 10332
<211> 708
<212> PRT
<213> Homo sapiens
<308> XP_051211
<400> 10332

Met Asn Pro Thr Glu Thr Lys Ala Ile Pro Val Ser Gln Gln Met Glu 
  1               5                  10                  15
Gly Pro His Leu Pro Asn Lys Lys Lys His Lys Lys Gln Ala Val Lys 
             20                  25                  30
Thr Glu Pro Glu Lys Lys Ser Gln Ser Thr Lys Leu Ser Val Val His 
         35                  40                  45
Glu Lys Lys Ser Gln Glu Gly Lys Pro Lys Glu His Thr Glu Pro Lys 
     50                  55                  60
Ser Leu Pro Lys Gln Ala Ser Asp Thr Gly Ser Asn Asp Ala His Asn 
 65                  70                  75                  80
Lys Lys Ala Val Ser Arg Ser Ala Glu Gln Gln Pro Ser Glu Lys Ser 
                 85                  90                  95
Thr Glu Pro Lys Thr Lys Pro Gln Asp Met Ile Ser Ala Gly Gly Glu 
             100                105                110
Ser Val Ala Gly Ile Thr Ala Ile Ser Gly Lys Pro Gly Asp Lys Lys 
         115                120                125
Lys Glu Lys Lys Ser Leu Thr Pro Ala Val Pro Val Glu Ser Lys Pro 
     130                135                140
Asp Lys Pro Ser Gly Lys Ser Gly Met Asp Ala Ala Leu Asp Asp Leu 
 145                150                155                160
Ile Asp Thr Leu Gly Gly Pro Glu Glu Thr Glu Glu Glu Asn Thr Thr 
                 165                170                175
Tyr Thr Gly Pro Glu Val Ser Asp Pro Met Ser Ser Thr Tyr Ile Glu 
             180                185                190
Glu Leu Gly Lys Arg Glu Val Thr Ile Pro Pro Lys Tyr Arg Glu Leu 
         195                200                205
Leu Ala Lys Lys Glu Gly Ile Thr Gly Pro Pro Ala Asp Ser Ser Lys 
     210                215                220
Pro Ile Gly Pro Asp Asp Ala Ile Asp Ala Leu Ser Ser Asp Phe Thr 
 225                230                235                240
Cys Gly Ser Pro Thr Ala Ala Gly Lys Lys Thr Glu Lys Glu Glu Ser 
                 245                250                255
Thr Glu Val Leu Lys Ala Gln Ser Ala Gly Thr Val Arg Ser Ala Ala 
             260                265                270
Pro Pro Gln Glu Lys Lys Arg Lys Val Glu Lys Asp Thr Met Ser Asp 
         275                280                285
Gln Ala Leu Glu Ala Leu Ser Ala Ser Leu Gly Thr Arg Gln Ala Glu 
     290                295                300
Pro Glu Leu Asp Leu Arg Ser Ile Lys Glu Val Asp Glu Ala Lys Ala 
 305                310                315                320
Lys Glu Glu Lys Leu Glu Lys Cys Gly Glu Asp Asp Glu Thr Ile Pro 
                 325                330                335
Ser Glu Tyr Arg Leu Lys Pro Ala Thr Asp Lys Asp Gly Lys Pro Leu 
             340                345                350
Leu Pro Glu Pro Glu Glu Lys Pro Lys Pro Arg Ser Glu Ser Glu Leu 
         355                360                365
Ile Asp Glu Leu Ser Glu Asp Phe Asp Arg Ser Glu Cys Lys Glu Lys 
     370                375                380
Pro Ser Lys Pro Thr Glu Lys Thr Glu Glu Ser Lys Ala Ala Ala Pro 
 385                390                395                400
Ala Pro Val Ser Glu Ala Val Cys Arg Thr Ser Met Cys Ser Ile Gln 
                 405                410                415
Ser Ala Pro Pro Glu Pro Ala Thr Leu Lys Gly Thr Val Pro Asp Asp 
             420                425                430
Ala Val Glu Ala Leu Ala Asp Ser Leu Gly Lys Lys Glu Ala Asp Pro 
         435                440                445
Glu Asp Gly Lys Pro Val Met Asp Lys Val Lys Glu Lys Ala Lys Glu 
     450                455                460
Glu Asp Arg Glu Lys Leu Gly Glu Lys Glu Glu Thr Ile Pro Pro Asp 
 465                470                475                480
Tyr Arg Leu Glu Glu Val Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro 
                 485                490                495
Lys Glu Ser Lys Glu Gln Leu Pro Pro Met Ser Glu Asp Phe Leu Leu 
             500                505                510
Asp Ala Leu Ser Glu Asp Phe Ser Gly Pro Gln Asn Ala Ser Ser Leu 
         515                520                525
Lys Phe Glu Asp Ala Lys Leu Ala Ala Ala Ile Ser Glu Val Val Ser 
     530                535                540
Gln Thr Pro Ala Ser Thr Thr Gln Ala Gly Ala Pro Pro Arg Asp Thr 
 545                550                555                560
Ser Gln Ser Asp Lys Asp Leu Asp Asp Ala Leu Asp Lys Leu Ser Asp 
                 565                570                575
Ser Leu Gly Gln Arg Gln Pro Asp Pro Asp Glu Asn Lys Pro Met Glu 
             580                585                590
Asp Lys Val Lys Glu Lys Ala Lys Ala Glu His Arg Asp Lys Leu Gly 
         595                600                605
Glu Arg Asp Asp Thr Ile Pro Pro Glu Tyr Arg His Leu Leu Asp Asp 
     610                615                620
Asn Gly Gln Asp Lys Pro Val Lys Pro Pro Thr Lys Lys Ser Glu Asp 
 625                630                635                640
Ser Lys Lys Pro Ala Asp Asp Gln Asp Pro Ile Asp Ala Leu Ser Gly 
                 645                650                655
Asp Leu Asp Ser Cys Pro Ser Thr Thr Glu Thr Ser Gln Asn Thr Ala 
             660                665                670
Lys Asp Lys Cys Lys Lys Ala Ala Ser Ser Ser Lys Ala Pro Lys Asn 
         675                680                685
Gly Gly Lys Ala Lys Asp Ser Ala Lys Thr Thr Glu Glu Thr Ser Lys 
     690                695                700
Pro Lys Asp Asp 
 705



<210> 10333
<211> 606
<212> DNA
<213> Rattus norvegicus
<308> Y13591
<400> 10333

ctggcacat  tcccagaat  agtaccaca  gagctaagg  tgtgaaaat  gagtctgag  60
agtctcaat  aagtgagcc  cctgtgatt  atgagaaaa  gccaaaagg  aagccaaag  120
aagggtcag  gacaaaatt  caagatgct  cttctgctg  tggagagag  gtggctgga  180
gtgtgactg  ggccactgc  tcagacaag  tggttgtta  gaaaaaaga  aagaaatca  240
taacaccta  tttacctat  gagtccaca  taaacaagc  atctgacaa  tcaggcgtg  300
atgctgctt  ggatgacct  atagacacc  taggtgaat  tgaagatac  aacaaagat  360
atccaccat  tactggacc  gtagttctg  acccaatgg  ttctaccta  cttgaggca  420
tgggtataa  agaagagac  attcctcca  agtatagga  acttctgga  aaaaatgaa  480
ctatcacag  acctcttcc  gattctcct  aacctatgg  aatcgacca  gctatagat  540
caacataaa  tttatgcat  ttggtatct  aataaaaat  cttcagctg  tggatggtg  600
ctttta  606



<210> 10334
<211> 176
<212> PRT
<213> Rattus norvegicus
<308> CAA73919
<400> 10334

Met Ser Thr Thr Gly Ala Lys Ala Val Lys Ile Glu Ser Glu Lys Ser 
  1               5                  10                  15
Gln Ser Ser Glu Pro Pro Val Ile His Glu Lys Lys Pro Lys Gly Lys 
             20                  25                  30
Pro Lys Glu Gly Ser Glu Thr Lys Phe Gln Asp Ala Pro Ser Ala Asp 
         35                  40                  45
Gly Glu Ser Val Ala Gly Gly Val Thr Val Ala Thr Ala Ser Asp Lys 
     50                  55                  60
Val Val Val Lys Lys Lys Glu Lys Lys Ser Leu Thr Pro Thr Leu Pro 
 65                  70                  75                  80
Met Glu Ser Thr Leu Asn Lys Leu Ser Asp Lys Ser Gly Val Asn Ala 
                 85                  90                  95
Ala Leu Asp Asp Leu Ile Asp Thr Leu Gly Glu Cys Glu Asp Thr Asn 
             100                105                110
Lys Asp Asp Pro Pro Tyr Thr Gly Pro Val Val Leu Asp Pro Met Asp 
         115                120                125
Ser Thr Tyr Leu Glu Ala Leu Gly Ile Lys Glu Glu Thr Ile Pro Pro 
     130                135                140
Glu Tyr Arg Lys Leu Leu Glu Lys Asn Glu Ala Ile Thr Gly Pro Leu 
 145                150                155                160
Pro Asp Ser Pro Lys Pro Met Gly Ile Asp His Ala Ile Asp Ala Thr 
                 165                170                175



<210> 10335
<211> 440
<212> DNA
<213> Homo sapiens
<308> AW995804
<400> 10335

gtctcttct  tggcttctc  ttgacttta  ccatcacag  ttttccatc  tctggatct  60
cttcctctt  ccccaggct  tcagccaag  cttctacag  atcatctgg  actgtgccc  120
tcaaggtag  cggctcagg  ggtgctgac  gtatactac  catggaggt  cgacacaca  180
cctccgaca  aggagctgg  gcagcggcc  tagattctt  tgtcctttc  gttggctta  240
atggtttct  tttacattc  gaccggtca  aatcttctg  aataaatca  agaagagaa  300
cactttttg  atttttaat  caggtcctt  tgtgtgtat  aaatacaca  atatcttcc  360
tattagtca  ggaagggca  aagtggacc  aaaacaggt  agctaagac  ggcatgtct  420
gcttctggg  tgtagctcag  440



<210> 10336
<211> 708
<212> PRT
<213> Homo sapiens
<308> XP_051211
<400> 10336

Met Asn Pro Thr Glu Thr Lys Ala Ile Pro Val Ser Gln Gln Met Glu 
  1               5                  10                  15
Gly Pro His Leu Pro Asn Lys Lys Lys His Lys Lys Gln Ala Val Lys 
             20                  25                  30
Thr Glu Pro Glu Lys Lys Ser Gln Ser Thr Lys Leu Ser Val Val His 
         35                  40                  45
Glu Lys Lys Ser Gln Glu Gly Lys Pro Lys Glu His Thr Glu Pro Lys 
     50                  55                  60
Ser Leu Pro Lys Gln Ala Ser Asp Thr Gly Ser Asn Asp Ala His Asn 
 65                  70                  75                  80
Lys Lys Ala Val Ser Arg Ser Ala Glu Gln Gln Pro Ser Glu Lys Ser 
                 85                  90                  95
Thr Glu Pro Lys Thr Lys Pro Gln Asp Met Ile Ser Ala Gly Gly Glu 
             100                105                110
Ser Val Ala Gly Ile Thr Ala Ile Ser Gly Lys Pro Gly Asp Lys Lys 
         115                120                125
Lys Glu Lys Lys Ser Leu Thr Pro Ala Val Pro Val Glu Ser Lys Pro 
     130                135                140
Asp Lys Pro Ser Gly Lys Ser Gly Met Asp Ala Ala Leu Asp Asp Leu 
 145                150                155                160
Ile Asp Thr Leu Gly Gly Pro Glu Glu Thr Glu Glu Glu Asn Thr Thr 
                 165                170                175
Tyr Thr Gly Pro Glu Val Ser Asp Pro Met Ser Ser Thr Tyr Ile Glu 
             180                185                190
Glu Leu Gly Lys Arg Glu Val Thr Ile Pro Pro Lys Tyr Arg Glu Leu 
         195                200                205
Leu Ala Lys Lys Glu Gly Ile Thr Gly Pro Pro Ala Asp Ser Ser Lys 
     210                215                220
Pro Ile Gly Pro Asp Asp Ala Ile Asp Ala Leu Ser Ser Asp Phe Thr 
 225                230                235                240
Cys Gly Ser Pro Thr Ala Ala Gly Lys Lys Thr Glu Lys Glu Glu Ser 
                 245                250                255
Thr Glu Val Leu Lys Ala Gln Ser Ala Gly Thr Val Arg Ser Ala Ala 
             260                265                270
Pro Pro Gln Glu Lys Lys Arg Lys Val Glu Lys Asp Thr Met Ser Asp 
         275                280                285
Gln Ala Leu Glu Ala Leu Ser Ala Ser Leu Gly Thr Arg Gln Ala Glu 
     290                295                300
Pro Glu Leu Asp Leu Arg Ser Ile Lys Glu Val Asp Glu Ala Lys Ala 
 305                310                315                320
Lys Glu Glu Lys Leu Glu Lys Cys Gly Glu Asp Asp Glu Thr Ile Pro 
                 325                330                335
Ser Glu Tyr Arg Leu Lys Pro Ala Thr Asp Lys Asp Gly Lys Pro Leu 
             340                345                350
Leu Pro Glu Pro Glu Glu Lys Pro Lys Pro Arg Ser Glu Ser Glu Leu 
         355                360                365
Ile Asp Glu Leu Ser Glu Asp Phe Asp Arg Ser Glu Cys Lys Glu Lys 
     370                375                380
Pro Ser Lys Pro Thr Glu Lys Thr Glu Glu Ser Lys Ala Ala Ala Pro 
 385                390                395                400
Ala Pro Val Ser Glu Ala Val Cys Arg Thr Ser Met Cys Ser Ile Gln 
                 405                410                415
Ser Ala Pro Pro Glu Pro Ala Thr Leu Lys Gly Thr Val Pro Asp Asp 
             420                425                430
Ala Val Glu Ala Leu Ala Asp Ser Leu Gly Lys Lys Glu Ala Asp Pro 
         435                440                445
Glu Asp Gly Lys Pro Val Met Asp Lys Val Lys Glu Lys Ala Lys Glu 
     450                455                460
Glu Asp Arg Glu Lys Leu Gly Glu Lys Glu Glu Thr Ile Pro Pro Asp 
 465                470                475                480
Tyr Arg Leu Glu Glu Val Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro 
                 485                490                495
Lys Glu Ser Lys Glu Gln Leu Pro Pro Met Ser Glu Asp Phe Leu Leu 
             500                505                510
Asp Ala Leu Ser Glu Asp Phe Ser Gly Pro Gln Asn Ala Ser Ser Leu 
         515                520                525
Lys Phe Glu Asp Ala Lys Leu Ala Ala Ala Ile Ser Glu Val Val Ser 
     530                535                540
Gln Thr Pro Ala Ser Thr Thr Gln Ala Gly Ala Pro Pro Arg Asp Thr 
 545                550                555                560
Ser Gln Ser Asp Lys Asp Leu Asp Asp Ala Leu Asp Lys Leu Ser Asp 
                 565                570                575
Ser Leu Gly Gln Arg Gln Pro Asp Pro Asp Glu Asn Lys Pro Met Glu 
             580                585                590
Asp Lys Val Lys Glu Lys Ala Lys Ala Glu His Arg Asp Lys Leu Gly 
         595                600                605
Glu Arg Asp Asp Thr Ile Pro Pro Glu Tyr Arg His Leu Leu Asp Asp 
     610                615                620
Asn Gly Gln Asp Lys Pro Val Lys Pro Pro Thr Lys Lys Ser Glu Asp 
 625                630                635                640
Ser Lys Lys Pro Ala Asp Asp Gln Asp Pro Ile Asp Ala Leu Ser Gly 
                 645                650                655
Asp Leu Asp Ser Cys Pro Ser Thr Thr Glu Thr Ser Gln Asn Thr Ala 
             660                665                670
Lys Asp Lys Cys Lys Lys Ala Ala Ser Ser Ser Lys Ala Pro Lys Asn 
         675                680                685
Gly Gly Lys Ala Lys Asp Ser Ala Lys Thr Thr Glu Glu Thr Ser Lys 
     690                695                700
Pro Lys Asp Asp 
 705



<210> 10337
<211> 1950
<212> DNA
<213> Rattus norvegicus
<308> Y15054
<400> 10337

gaggatccg  gtaccatgc  ccaacctta  aggactcaa  ctcacaaca  cgggcgaaa  60
cgatggctt  tgcgctaac  gactgcgtg  ggcggttcc  ctgctcagc  gtggtgggc  120
ggtagctgt  cttgagctg  agaagccag  ccgcctgcc  gacacagga  tgcctacgc  180
tcagaatgg  gcggctgta  tggatctgg  ctgggatcc  tttgatccg  accggcttg  240
tgtggctgg  gaggacgcc  ggatccggc  gtggcgggt  ccccctggt  gcctcaaga  300
cattctcac  acacctgag  ctgtgctta  aggccacac  gaaaagatt  actctctgc  360
cttccaccc  ctggctgcc  atgtactgg  ttccagttc  tatgaccta  ccattcgta  420
ctgggacct  caggctaga  ctgagcagc  aaggctgca  ggccatcag  accagattt  480
cagcctggc  tggagtcca  atggaaagc  gctggccac  gtctgcaag  atgggcgtg  540
tcgggtcta  gatccccgg  gcagccctt  acccctgca  gacggtcca  gacctgaag  600
tggccgcgg  gccgcatcg  ctgggtgtg  aatggtggt  gtctgctgg  atctggttt  660
gacagccga  gtgagcgcc  gctgcagct  tacatggct  atgccctgg  agaaggccc  720
tcagcactg  tgggcctcg  ttgtagctc  ctctaccct  cttcctagc  atgaccctg  780
cacaggcct  gtgcttctc  ctggcaagg  agatacccg  gtgttcctg  acgaggtga  840
cccagaggc  cccttcttc  tggagtgca  cagcttcac  tcacctgac  ctcacaagg  900
ctttatcct  ctgcccaag  ctgagtgtg  cattcagga  gtggagttt  cccgatgcc  960
gcggctacg  cagacctcc  tggagcctg  tgctttccg  ctgccccgg  tcagaaaag  1020
attccaaga  gatgtgttc  cagatacag  tgtgacctg  gcgtccgca  tcgacgcca  1080
agcctggtt  aagggtgct  atggacaac  ccggctact  agtttacag  cccctggca  1140
gaccccagt  agccaagcc  cccgggagg  ccctgcccg  agaacccca  cctcagcac  1200
gtacttgga  gagaagtct  accagcaaa  gaaagaaga  ctgctgaat  ccatggtgg  1260
aaagctggg  aaccgagaa  acccactgc  ccaggactc  tttgaaggg  tggatgaag  1320
tgagtggga  tagcctgca  gtgaggcac  cctacccac  gctgccact  ccacctccc  1380
gaaccgcct  cggcccctc  acaccttat  tctctgcaa  ctgaacagt  ctgcgctgg  1440
cctggcaca  acatccagc  cagaagccc  gggcttcat  caggcctca  gcacttcca  1500
agctgctgg  cctcgccgc  gctccagag  ctgtctgct  ctttgctgt  tggggccag  1560
tgtttattc  cagcggcct  tcagcatga  acaccactg  gtgggaggt  ggtgtcagt  1620
gcatgtctc  gggccaacc  tggatggcc  ggctctcct  gtctttctc  ggttttctc  1680
aacatcatc  gccgtcact  caagccaag  tatcttgcc  accgcacca  ccccagtca  1740
ggacactgg  agctggtcc  ccacaggct  ttggggaca  ctctctcct  gggcctagg  1800
accatttgc  ctgcttctt  gggcttgag  accaggaga  agggtctcg  ggagctaac  1860
gccttcatt  cagtggtgt  gaccccaca  caaacagcc  atacactct  gatgtgtcc  1920
gcaattaaa  ttttctaag  taaaaaaaaa  1950



<210> 10338
<211> 443
<212> PRT
<213> Rattus norvegicus
<308> O35828
<400> 10338

Arg Ile Arg Val Pro Cys Thr Asn Leu Lys Gly Leu Asn Leu Thr Thr 
  1               5                  10                  15
Pro Gly Glu Ser Asp Gly Phe Cys Ala Asn Arg Leu Arg Val Ala Val 
             20                  25                  30
Pro Leu Leu Ser Ser Gly Gly Gln Val Ala Val Leu Glu Leu Gln Lys 
         35                  40                  45
Pro Gly Arg Leu Pro Asp Thr Gly Leu Pro Thr Leu Gln Asn Gly Ala 
     50                  55                  60
Ala Val Met Asp Leu Val Trp Asp Pro Phe Asp Pro His Arg Leu Ala 
 65                  70                  75                  80
Val Ala Gly Glu Asp Ala Arg Ile Arg Leu Trp Arg Val Pro Pro Gly 
                 85                  90                  95
Gly Leu Lys Asn Ile Leu Thr Thr Pro Glu Thr Val Leu Thr Gly His 
             100                105                110
Thr Glu Lys Ile Tyr Ser Leu Arg Phe His Pro Leu Ala Ala Asp Val 
         115                120                125
Leu Ala Ser Ser Ser Tyr Asp Leu Thr Ile Arg Ile Trp Asp Leu Gln 
     130                135                140
Ala Arg Thr Glu Gln Leu Arg Leu Gln Gly His Gln Asp Gln Ile Phe 
 145                150                155                160
Ser Leu Ala Trp Ser Pro Asp Gly Lys Gln Leu Ala Thr Val Cys Lys 
                 165                170                175
Asp Gly Arg Val Arg Val Tyr Asp Pro Arg Ser Ser Pro Leu Pro Leu 
             180                185                190
Gln Asp Gly Pro Gly Pro Glu Gly Gly Arg Gly Ala Ala Ser Ser Gly 
         195                200                205
Cys Val Met Val Val Val Cys Trp Tyr Leu Val Leu Thr Ala Glu Val 
     210                215                220
Ser Ala Ser Cys Ser Cys Thr Trp Leu Met Pro Trp Gln Lys Ala Leu 
 225                230                235                240
Gln His Cys Trp Ala Ser Ile Val Ala Pro Ser Thr Leu Leu Pro Ser 
                 245                250                255
Tyr Asp Pro Asp Thr Gly Leu Val Leu Leu Thr Gly Lys Gly Asp Thr 
             260                265                270
Arg Val Phe Leu Tyr Glu Val Ile Pro Glu Ala Pro Phe Phe Leu Glu 
         275                280                285
Cys Asn Ser Phe Thr Ser Pro Asp Pro His Lys Gly Phe Ile Leu Leu 
     290                295                300
Pro Lys Thr Glu Cys Asp Ile Gln Asp Val Glu Phe Ala Arg Cys Leu 
 305                310                315                320
Arg Leu Arg Gln Thr Ser Leu Glu Pro Val Ala Phe Arg Leu Pro Arg 
                 325                330                335
Val Arg Lys Glu Phe Gln Asp Asp Val Phe Pro Asp Thr Ala Val Thr 
             340                345                350
Trp Ala Ser Ala Leu Asp Ala Lys Ala Trp Phe Lys Gly Ala Asn Gly 
         355                360                365
Gln Pro Arg Leu Leu Ser Leu Gln Pro Pro Gly Met Thr Pro Val Ser 
     370                375                380
Gln Ala Pro Arg Glu Val Pro Ala Arg Arg Thr Pro Ser Ser Ala Gln 
 385                390                395                400
Tyr Leu Glu Glu Lys Ser Asp Gln Gln Lys Lys Glu Glu Leu Leu Asn 
                 405                410                415
Ala Met Val Ala Lys Leu Gly Asn Arg Glu Asp Pro Leu Pro Gln Asp 
             420                425                430
Ser Phe Glu Gly Val Asp Glu Asp Glu Trp Asp 
         435                440



<210> 10339
<211> 1632
<212> DNA
<213> Rattus norvegicus
<308> Y15068
<400> 10339

atggagcag  tgaatgagc  aaaggagaa  ggcaataag  ccctgagtg  tgggaacat  60
gatgatgcc  tacagtgct  ctctgaggc  attaaacta  atcctcaga  ccatgtgct  120
tatagcaat  gctctgcag  ctatgccaa  aaaggagac  accagaagg  gtatgagga  180
ggttgcaag  ctgttgacc  gaagcctga  tggggcaag  gttattcaa  aaaagcagc  240
gcccttgag  tcctaaacc  gtttgaaga  gccaaacga  cctatgaag  aggtttaaa  300
catgaagcc  ataatctac  gcttaagga  ggcttgcag  acatggagg  caggttggc  360
gagaggaaa  ttatgaatc  tttcaactt  cctaatctg  accagaagt  agagaatga  420
cccaggaca  ggacactgc  cagtgaccc  acctacagg  aactcatag  gcaactaca  480
aacaagcct  cagacctgg  cacgaaact  caagatccc  gggtcatga  tactctcag  540
gtcctcctt  gagttgatc  gggcagtat  gatgaagag  aagaggcag  aacaccccc  600
cctccaccc  ctcctaaaa  ggaggccaa  ccagaacca  tggaagaag  tcttccaga  660
aataagaaa  aggctctga  agaaaagga  ctgggaaat  atgcctaca  gaagaaaga  720
tttgacaag  ccctgaagc  ttatgacaa  gccaaggag  tggacccta  caatatgac  780
tacataact  atcaagcag  tgtgcactt  gagaagggc  actacaaca  atgccggga  840
ctctgtgag  aggccattg  agtaggcag  gagaaccga  aggactacc  tcagatcgc  900
aaagcttat  ctcgaattg  caattccta  ttcaaagaa  aaaggtaca  ggatgctat  960
catttctac  acaagtctc  ggcagagca  cgaacccca  atgtgctca  gaagtgcca  1020
caggcagag  aaattctga  ggaacaaga  cgactggct  atatcaacc  tgatttggc  1080
ttggaggaa  agaataagg  caatgagtg  ttccagaaa  gggactacc  ccaggccat  1140
aagcactat  cagaagcca  taaaaggaa  ccaagagat  ccaaactat  cagcaaccg  1200
gccgcctgc  acaccaagc  cctggagtt  cagctggca  tcaaggact  tgaagagtg  1260
atccagcta  agccaacct  catcaaggg  tatacacgg  aagcagctg  cctggaagc  1320
atgaaggac  atacaaaag  catggatgt  taccagaag  cattagacc  ggactccag  1380
tgtaaggaa  cagcagatg  ttaccaacg  tgtatgatg  cacagtaca  cagacatga  1440
agccctgag  atgtgaaac  gcgggccat  gctgaccct  aggtacagc  gataatgag  1500
gacccagcc  tgaggctca  cctggagca  atgcaaaag  acccccaag  tctgagcga  1560
cacttaaag  atcctgtaa  agcacagaa  atccagaag  tgatggatg  gggtctcat  1620
gcaattcgg  ga  1632



<210> 10340
<211> 544
<212> PRT
<213> Rattus norvegicus
<308> Y15068
<400> 10340

Met Glu Gln Val Asn Glu Leu Lys Glu Lys Gly Asn Lys Ala Leu Ser 
  1               5                  10                  15
Ala Gly Asn Ile Asp Asp Ala Leu Gln Cys Tyr Ser Glu Ala Ile Lys 
             20                  25                  30
Leu Asp Pro Gln Asn His Val Leu Tyr Ser Asn Arg Ser Ala Ala Tyr 
         35                  40                  45
Ala Lys Lys Gly Asp Tyr Gln Lys Ala Tyr Glu Asp Gly Cys Lys Thr 
     50                  55                  60
Val Asp Leu Lys Pro Asp Trp Gly Lys Gly Tyr Ser Arg Lys Ala Ala 
 65                  70                  75                  80
Ala Leu Glu Phe Leu Asn Arg Phe Glu Glu Ala Lys Arg Thr Tyr Glu 
                 85                  90                  95
Glu Gly Leu Lys His Glu Ala Asn Asn Leu Gln Leu Lys Glu Gly Leu 
             100                105                110
Gln Asn Met Glu Ala Arg Leu Ala Glu Arg Lys Phe Met Asn Pro Phe 
         115                120                125
Asn Leu Pro Asn Leu Tyr Gln Lys Leu Glu Asn Asp Pro Arg Thr Arg 
     130                135                140
Thr Leu Leu Ser Asp Pro Thr Tyr Arg Glu Leu Ile Glu Gln Leu Gln 
 145                150                155                160
Asn Lys Pro Ser Asp Leu Gly Thr Lys Leu Gln Asp Pro Arg Val Met 
                 165                170                175
Thr Thr Leu Ser Val Leu Leu Gly Val Asp Leu Gly Ser Met Asp Glu 
             180                185                190
Glu Glu Glu Ala Ala Thr Pro Pro Pro Pro Pro Pro Pro Lys Lys Glu 
         195                200                205
Ala Lys Pro Glu Pro Met Glu Glu Asp Leu Pro Glu Asn Lys Lys Gln 
     210                215                220
Ala Leu Lys Glu Lys Glu Leu Gly Asn Asp Ala Tyr Lys Lys Lys Asp 
 225                230                235                240
Phe Asp Lys Ala Leu Lys His Tyr Asp Lys Ala Lys Glu Leu Asp Pro 
                 245                250                255
Thr Asn Met Thr Tyr Ile Thr Asn Gln Ala Ala Val His Phe Glu Lys 
             260                265                270
Gly Asp Tyr Asn Lys Cys Arg Glu Leu Cys Glu Lys Ala Ile Glu Val 
         275                280                285
Gly Arg Glu Asn Arg Glu Asp Tyr Arg Gln Ile Ala Lys Ala Tyr Ala 
     290                295                300
Arg Ile Gly Asn Ser Tyr Phe Lys Glu Glu Arg Tyr Lys Asp Ala Ile 
 305                310                315                320
His Phe Tyr Asn Lys Ser Leu Ala Glu His Arg Thr Pro Asp Val Leu 
                 325                330                335
Lys Lys Cys Gln Gln Ala Glu Lys Ile Leu Lys Glu Gln Glu Arg Leu 
             340                345                350
Ala Tyr Ile Asn Pro Asp Leu Ala Leu Glu Glu Lys Asn Lys Gly Asn 
         355                360                365
Glu Cys Phe Gln Lys Gly Asp Tyr Pro Gln Ala Met Lys His Tyr Thr 
     370                375                380
Glu Ala Ile Lys Arg Asn Pro Arg Asp Ala Lys Leu Tyr Ser Asn Arg 
 385                390                395                400
Ala Ala Cys Tyr Thr Lys Leu Leu Glu Phe Gln Leu Ala Leu Lys Asp 
                 405                410                415
Cys Glu Glu Cys Ile Gln Leu Glu Pro Thr Phe Ile Lys Gly Tyr Thr 
             420                425                430
Arg Lys Ala Ala Ala Leu Glu Ala Met Lys Asp Tyr Thr Lys Ala Met 
         435                440                445
Asp Val Tyr Gln Lys Ala Leu Asp Leu Asp Ser Ser Cys Lys Glu Ala 
     450                455                460
Ala Asp Gly Tyr Gln Arg Cys Met Met Ala Gln Tyr Asn Arg His Asp 
 465                470                475                480
Ser Pro Glu Asp Val Lys Arg Arg Ala Met Ala Asp Pro Glu Val Gln 
                 485                490                495
Gln Ile Met Ser Asp Pro Ala Met Arg Leu Ile Leu Glu Gln Met Gln 
             500                505                510
Lys Asp Pro Gln Ala Leu Ser Glu His Leu Lys Asn Pro Val Ile Ala 
         515                520                525
Gln Lys Ile Gln Lys Leu Met Asp Val Gly Leu Ile Ala Ile Arg Ter 
     530                535                540



<210> 10341
<211> 2113
<212> DNA
<213> Homo sapiens
<308> M86752
<400> 10341

gtgcggttg  gaacgcgga  cggacggat  cgattcaac  gggttccgg  ccgcgctgc  60
ctatggagc  ggtcaatga  ctgaaggag  aaggcaaca  ggccctgag  gtgggtaac  120
tcgatgatg  cttacagtg  tactccgaa  ctattaagc  ggatcccca  aaccacgtg  180
tgtacagca  ccgttctgc  gcctatgcc  agaaaggag  ctaccagaa  gcttatgag  240
atggctgca  gactgtcga  ctaaagcct  actggggca  gggctattc  cgaaaagca  300
cagctctag  gttcttaaa  cgctttgaa  aagccaagc  aacctatga  gagggctta  360
aacacgagg  aaataaccc  caactgaaa  agggtttac  gaatatgga  gccaggttg  420
cagagagaa  attcatgaa  cctttcaac  tgcctaatc  gtatcagaa  ttggagagt  480
atcccagga  aaggacact  ctcagtgat  ctacctacc  ggagctgat  gagcagcta  540
gaaacaagc  ttctgacct  ggcacgaaa  tacaagatc  ccggatcat  accactctc  600
gcgtcctcc  tggggtcga  ctgggcagt  tggatgagg  ggaagagat  gcaacacct  660
caccaccac  ccctcccaa  aaggagacc  agccagagc  aatggaaga  gatcttcca  720
agaataaga  gcaggcact  aaagaaaaa  agctgggga  cgatgccta  aagaagaaa  780
actttgaca  agccttgaa  cattacgac  aagccaagg  gctggaccc  actaacatg  840
cttacatta  caatcaagc  gcggtatac  ttgaaaagg  cgactacaa  aagtgccgg  900
agctttgtg  gaaggccat  gaagtgggg  gagaaaacc  agaagacta  cgacagatt  960
ccaaagcat  tgctcgaat  ggcaactcc  acttcaaag  agaaaagta  aaggatgcc  1020
tccatttct  taacaagtc  ctggcagag  accgaaccc  agatgtgct  aagaaatgc  1080
agcaggcag  gaaaatcct  aaggagcaa  agcggctgg  ctacataaa  cccgacctg  1140
ctttggagg  gaagaacaa  ggcaacgag  gttttcaga  aggggacta  ccccaggcc  1200
tgaagcatt  tacagaagc  atcaaaagg  acccgaaag  tgccaaatt  tacagcaat  1260
gagctgcct  ctacaccaa  ctcctggag  tccagctgg  actcaagga  tgtgaggaa  1320
gtatccagc  ggagccgac  ttcatcaag  gttatacac  gaaagccgc  gcgctggaa  1380
cgatgaagg  ctacaccaa  gccatggat  tgtaccaga  ggcgctaga  ctggactcc  1440
gctgtaagg  ggcggcaga  ggctaccag  gctgtatga  ggcgcagta  aaccggcac  1500
acagccccg  agatgtgaa  cgacgagcc  tggccgacc  tgaggtgca  cagatcatg  1560
gtgacccag  catgcgcct  atcctggaa  agatgcaga  ggaccccca  gcactcagc  1620
aacacttaa  gaatcctgt  atagcacag  agatccaga  gctgatgga  gtgggtctg  1680
ttgcaattc  gtgatgact  gttcatccc  ccttccctt  gccctcatg  ggaaagagg  1740
gctgggacc  cggcgagca  cacggagcg  aagggagag  aggggagag  aggcctcat  1800
tctctatat  tatacataa  cccggggaa  acacagaga  tcgtacctg  gctgtttgt  1860
ccgccgctg  ctctgggcc  tcccagcac  cgcatggtc  cttcaccgc  gccctcgag  1920
tccatgtct  tttcccctg  ccctagttg  tgtctcggc  gctctccca  agttggttt  1980
ttttttatt  ggggcagtg  gcatgttat  gggagggga  ggggttctt  cagcctcag  2040
tcccagctg  ctcacgttg  ttattctgc  tccccttct  caataaaac  agccagttg  2100
gcgtggtta  aac  2113



<210> 10342
<211> 543
<212> PRT
<213> Homo sapiens
<308> P31948
<400> 10342

Met Glu Gln Val Asn Glu Leu Lys Glu Lys Gly Asn Lys Ala Leu Ser 
  1               5                  10                  15
Val Gly Asn Ile Asp Asp Ala Leu Gln Cys Tyr Ser Glu Ala Ile Lys 
             20                  25                  30
Leu Asp Pro His Asn His Val Leu Tyr Ser Asn Arg Ser Ala Ala Tyr 
         35                  40                  45
Ala Lys Lys Gly Asp Tyr Gln Lys Ala Tyr Glu Asp Gly Cys Lys Thr 
     50                  55                  60
Val Asp Leu Lys Pro Asp Trp Gly Lys Gly Tyr Ser Arg Lys Ala Ala 
 65                  70                  75                  80
Ala Leu Glu Phe Leu Asn Arg Phe Glu Glu Ala Lys Arg Thr Tyr Glu 
                 85                  90                  95
Glu Gly Leu Lys His Glu Ala Asn Asn Pro Gln Leu Lys Glu Gly Leu 
             100                105                110
Gln Asn Met Glu Ala Arg Leu Ala Glu Arg Lys Phe Met Asn Pro Phe 
         115                120                125
Asn Met Pro Asn Leu Tyr Gln Lys Leu Glu Ser Asp Pro Arg Thr Arg 
     130                135                140
Thr Leu Leu Ser Asp Pro Thr Tyr Arg Glu Leu Ile Glu Gln Leu Arg 
 145                150                155                160
Asn Lys Pro Ser Asp Leu Gly Thr Lys Leu Gln Asp Pro Arg Ile Met 
                 165                170                175
Thr Thr Leu Ser Val Leu Leu Gly Val Asp Leu Gly Ser Met Asp Glu 
             180                185                190
Glu Glu Glu Ile Ala Thr Pro Pro Pro Pro Pro Pro Pro Lys Lys Glu 
         195                200                205
Thr Lys Pro Glu Pro Met Glu Glu Asp Leu Pro Glu Asn Lys Lys Gln 
     210                215                220
Ala Leu Lys Glu Lys Glu Leu Gly Asn Asp Ala Tyr Lys Lys Lys Asp 
 225                230                235                240
Phe Asp Thr Ala Leu Lys His Tyr Asp Lys Ala Lys Glu Leu Asp Pro 
                 245                250                255
Thr Asn Met Thr Tyr Ile Thr Asn Gln Ala Ala Val Tyr Phe Glu Lys 
             260                265                270
Gly Asp Tyr Asn Lys Cys Arg Glu Leu Cys Glu Lys Ala Ile Glu Val 
         275                280                285
Gly Arg Glu Asn Arg Glu Asp Tyr Arg Gln Ile Ala Lys Ala Tyr Ala 
     290                295                300
Arg Ile Gly Asn Ser Tyr Phe Lys Glu Glu Lys Tyr Lys Asp Ala Ile 
 305                310                315                320
His Phe Tyr Asn Lys Ser Leu Ala Glu His Arg Thr Pro Asp Val Leu 
                 325                330                335
Lys Lys Cys Gln Gln Ala Glu Lys Ile Leu Lys Glu Gln Glu Arg Leu 
             340                345                350
Ala Tyr Ile Asn Pro Asp Leu Ala Leu Glu Glu Lys Asn Lys Gly Asn 
         355                360                365
Glu Cys Phe Gln Lys Gly Asp Tyr Pro Gln Ala Met Lys His Tyr Thr 
     370                375                380
Glu Ala Ile Lys Arg Asn Pro Lys Asp Ala Lys Leu Tyr Ser Asn Arg 
 385                390                395                400
Ala Ala Cys Tyr Thr Lys Leu Leu Glu Phe Gln Leu Ala Leu Lys Asp 
                 405                410                415
Cys Glu Glu Cys Ile Gln Leu Glu Pro Thr Phe Ile Lys Gly Tyr Thr 
             420                425                430
Arg Lys Ala Ala Ala Leu Glu Ala Met Lys Asp Tyr Thr Lys Ala Met 
         435                440                445
Asp Val Tyr Gln Lys Ala Leu Asp Leu Asp Ser Ser Cys Lys Glu Ala 
     450                455                460
Ala Asp Gly Tyr Gln Arg Cys Met Met Ala Gln Tyr Asn Arg His Asp 
 465                470                475                480
Ser Pro Glu Asp Val Lys Arg Arg Ala Met Ala Asp Pro Glu Val Gln 
                 485                490                495
Gln Ile Met Ser Asp Pro Ala Met Arg Leu Ile Leu Glu Gln Met Gln 
             500                505                510
Lys Asp Pro Gln Ala Leu Ser Glu His Leu Lys Asn Pro Val Ile Ala 
         515                520                525
Gln Lys Ile Gln Lys Leu Met Asp Val Gly Leu Ile Ala Ile Arg 
     530                535                540



<210> 10343
<211> 1879
<212> DNA
<213> Rattus norvegicus
<308> Y15748
<400> 10343

gcggccgcg  ggagcagcg  aacgctgcg  gggaggcgc  cgcgccgac  cggggctca  60
ggccaggac  accagccag  tgtatgacg  tgtgcccat  cagtccagt  tggtgctat  120
ttcctgccc  tccccatca  tggtgaggt  ccagactga  cccagctcg  cccctggca  180
tcctagtgg  gttagcagg  agggatcca  catggacgg  accacagct  aagcccgac  240
aagcaccaa  cccttgcag  agcaccctg  ccagctgcc  ccacagcct  gcaagaaac  300
ccctgaaga  ttcaagttt  ggaaaattc  tggcgaggg  tctttttcg  cagttgttc  360
ggcccgaga  ctggccact  ccagagaat  tgctattaa  attctggag  aacgtcata  420
aataaaaga  aacaaagtc  cgtatgtaa  tagagagag  gatgtgatg  cacgcctgg  480
tcacccctt  tttgtgaaa  tttacttta  gtttcagga  gacgaaaag  tgtattttg  540
ccttagtta  gccaaaaat  gagagctac  caaatacat  cgcaaaatc  gttcatttg  600
tgagacctg  acccggttt  acacagctg  gattgtgtc  gctttagag  acttgcatg  660
caagggcat  attcacaga  accttaaac  agaaaacat  ttgttaaac  aagacatgc  720
catccagat  acagatttt  gaacagcca  agtattatc  ccagacagc  aacaagcta  780
agccaattc  tttgtagga  cagcgcagt  tgtttctcc  gagctgctc  cagagaagt  840
ggcgtgtaa  agttcagac  tttgggccc  tggatgtat  atctatcag  ttgtggcag  900
acttccacc  ttcagagcc  gaaatgaat  tcttatatt  cagaagatc  ttaagttgg  960
atatgattt  ccagaaaaa  tcttcccta  ggcaagaga  cttgtggaa  aactcttgg  1020
tttagatgc  acaaagcgt  taggctgtg  agagatgga  gggtacggg  ctctcaaag  1080
tcatccatt  tttgagtcc  tcacgtggg  gaatctgca  cagcagacg  ctccgaagc  1140
cacagctta  ttgccagcc  tgtcagaag  tgatgaaga  tgttatggc  attacgaca  1200
tctcctgag  cagtttggc  gcatgcagg  gtcatcatc  tcctcttcc  actccctgt  1260
tgcggtgga  gccagcctg  cccagaggt  gggcagcaa  atagagcag  acattcatg  1320
tttggacac  aactctttt  aactagact  acagttttc  gaagatgaa  aaaggttgt  1380
attggaaaa  caagccggt  gaaaccctt  gcaccagtt  gtagaaaat  atctaatat  1440
aaaaatggg  ccagtggat  agcgaaagg  tttatttgc  agacgacgg  agttattac  1500
cacagaagg  ccacattta  attatgtcg  tcctgtcaa  aaggtctta  aaggtgaaa  1560
tccatggtc  caagaactc  gaccagagg  caagaattt  aaaactttc  tcgtccaca  1620
gcctaacag  acgtattac  tgatggatc  aagcgggaa  gctcacaag  ggtgcagaa  1680
gatccagga  gtttggagg  aacagtacc  gagcagtcc  gatgctgct  tgcagtgac  1740
tggcctgcg  ccgggctgc  tatcgctgc  aggacacct  cctcagcgc  gctcggccg  1800
cacccagga  gcttccaga  cacctgcca  ccatctcaa  gagaacata  atggcaaaa  1860
ccttgcagc  tttttattt  1879



<210> 10344
<211> 559
<212> PRT
<213> Rattus norvegicus
<308> O55173
<400> 10344

Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser 
  1               5                  10                  15
Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Ser Gln 
             20                  25                  30
Thr Glu Pro Ser Ser Ser Pro Gly Ile Pro Ser Gly Val Ser Arg Gln 
         35                  40                  45
Gly Ser Thr Met Asp Gly Thr Thr Ala Glu Ala Arg Pro Ser Thr Asn 
     50                  55                  60
Pro Leu Gln Gln His Pro Ala Gln Leu Pro Pro Gln Pro Arg Lys Lys 
 65                  70                  75                  80
Arg Pro Glu Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe 
                 85                  90                  95
Ser Thr Val Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala 
             100                105                110
Ile Lys Ile Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro 
         115                120        